tbuckley/cabot-search huggingface dataset:
A renotropic system in rats.
Authors: H G Preuss, H Goldin
Journal: Journal of Clinical Investigation (1976)

While plasma or sera obtained from rats 20 h after removal of one kidney (uninephrectomy) stimulated [3H] thyrmidine incorporation into the DNA of kidney tissue incubating in vitro, azotemic plasma or sera obtained from rats 20 h after removal of both kidneys had no apparent effect. Dialysis of this azotemic sera resulted in its ability to stimulate isotope incorporation into renal DNA to the same degree as sera from uninephrectomized rats. This stimulatory factor (renotropin) was found to rise significantly within the first 26 h after uninephrectomy. Renotropin worked only on renal tissue, and we found that a factor could be extracted in large amounts from the remaining kidney 20 h after uninephrectomy that would stimulate renal DNA synthesis in the presence of sera. Based on these findings and others, we postulate that after uninephrectomy there is an elevation in circulating renotropin as well as a tissue factor in the remaining kidney. Both factors together probably produce an excitor which enhances [3H] thymidine into DNA. The latter is tightly bound to renal tissue, and its production and/or activity is modified by circulating inhibitors that are especially prominent in azotemia.
Spontaneous repopulation of β-catenin null livers with β-catenin-positive hepatocytes after chronic murine liver injury
Authors: Michael D. Thompson, Emily D. Wickline, William B. Bowen, Amy Lu, Sucha Singh, Amalea Misse, Satdarshan P.S. Monga
Journal: Hepatology (2011)

Prolonged exposure of mice to diet containing 0.1% 3,5-diethoxycarbonyl-1,4-dihydrocollidine (DDC) results in hepatobiliary injury, atypical ductular proliferation, oval cell appearance, and limited fibrosis. Previously, we reported that short-term ingestion of DDC diet by hepatocyte-specific β-catenin conditional knockout (KO) mice led to fewer A6-positive oval cells than wildtype (WT) littermates. To examine the role of β-catenin in chronic hepatic injury and repair, we exposed WT and KO mice to DDC for 80 and 150 days. Paradoxically, long-term DDC exposure led to significantly more A6-positive cells, indicating greater atypical ductular proliferation in KO, which coincided with increased fibrosis and cholestasis. Surprisingly, at 80 and 150 days in KO we observed a significant amelioration of hepatocyte injury. This coincided with extensive repopulation of β-catenin null livers with β-catenin-positive hepatocytes at 150 days, which was preceded by appearance of β-catenin-positive hepatocyte clusters at 80 days and a few β-catenin-positive hepatocytes at earlier times. Intriguingly, occasional β-catenin-positive hepatocytes that were negative for progenitor markers were also observed at baseline in the KO livers, suggesting spontaneous escape from cre-mediated recombination. These cells with hepatocyte morphology expressed mature hepatocyte markers but lacked markers of hepatic progenitors. The gradual repopulation of KO livers with β-catenin-positive hepatocytes occurred only following DDC injury and coincided with a progressive loss of hepatic cre-recombinase expression. A few β-catenin-positive cholangiocytes were observed albeit only after long-term DDC exposure and trailed the appearance of β-catenin-positive hepatocytes. Conclusion: In a chronic liver injury model, β-catenin-positive hepatocytes exhibit growth and survival advantages and repopulate KO livers, eventually limiting hepatic injury and dysfunction despite increased fibrosis and intrahepatic cholestasis. (Hepatology 2011;)
Cubital Tunnel External Compression Syndrome
Authors: T. G. Wadsworth, J. R. Williams
Journal: BMJ (1973)

External compression of the cubital tunnel comprises the acute and subacute forms of ulnar nerve compression at the elbow. Subacute compression is often seen in hospital practice and sometimes results in partial crippling of the hand. Prognosis for complete recovery is poor. Avoidance of a position of the elbow which predisposes to external compression of the ulnar nerve within the cubital tunnel is advised when a patient is on the operating table, in bed or in an armchair. Prolonged severe elbow flexion in these circumstances should also be avoided. The patient suffering from the syndrome should be instructed to avoid further pressure so that worsening of the palsy is minimized. A compressed nerve is likely to be more sensitive than a normal nerve to ischaemia produced by subsequent pressure. Surgical treatment is sometimes indicated at least to halt progression of the palsy.
Cardiologist is investigated for charging Medicare $18m in one year
Authors: O. Dyer
Journal: BMJ (2015)

The US Department of Justice has joined two whistleblower lawsuits against the country’s top billing cardiologist, Asad Qamar of Ocala, Florida, for charging Medicare for unnecessary interventions for peripheral vascular disease. 

The suits, filed under the False Claims Act, accuse the doctor, and his Institute for Cardiovascular Excellence, of intervening in almost every patient who is scanned for peripheral vascular disease.

It would be “statistically impossible to medically support the number of interventions for which Dr Qamar and ICE billed for in 2010-11,” one lawsuit contends. Of $18m (£12m; €16m) in Medicare payments that Qamar received in 2012—the second highest amount paid to any physician in the country—$13m was …
Reply to Andrea Minervini, Sergio Serni, Marco Carini and Claudio Di Cristofano’s Letter to the Editor re: Anders Lidgren, Ylva Hedberg, Kjell Grankvist, Torgny Rasmuson, Anders Bergh and Börje Ljungberg. Hypoxia-Inducible Factor 1α Expression in Renal Cell Carcinoma Analyzed by Tissue Microarray. Eur Urol 2006;50:1272–7
Authors: Börje Ljungberg, Anders Lidgren, Ylva Hedberg, Kjell Grankvist, Torgny Rasmuson, Anders Bergh
Journal: European Urology (2007)
European GPs don't know how to deal with obesity epidemic
Authors: Rhona MacDonald
Journal: BMJ (2005)

European GPs know that they are facing an obesity epidemic but do not know what to do about it, a debate on obesity heard last week. “European trends in obesity are now in parallel with [those in] the United States,” Christian Fabian, president of the European Union of General Practitioners and a GP in Sweden told the meeting. The debate was organised by the UK company Medical Futures, with a panel of obesity experts and delegates from the union.

Susan Jebb, head of nutrition and health research at the Medical Research Council in Cambridge, …
EXCISION OF THE ULCER-BEARING AREA IN GASTRIC ULCER.
Authors: WILLIAM L. RODMAN
Journal: JAMA (1904)

Rash, indeed, would be the surgeon who advocated operation in ail cases of gastric ulcer; but more rash would be he wx.o practiced excision of the ulcer-bearing area in all cases operated on. I wish it distinctly understood that it is only in certain well-selected cases that the proposed operation has, or may ever have, an accepted place in surgery. We are all agreed that 25 or 50 per cent. of the cases of ulcer of the stomach may be cured by medical means. These will usually be the cases of acute round ulcer found in females under the age of 30. They are also frequently found in connection with chlorosis, and it has been found that, as a general rule, they heal under medicinal treatment. It has also been learned that the chronic ulcers, usually found in males past the age of 40, are the ones which interfere seriously
939-77 Cellular Mechanisms for Alpha1-adrenoceptormediated Cardioprotection: Role of Protein Kinase C and Ecto-5’-Nucleotidase in Ischemic Preconditioning
Authors: Koichi Node, Masafumi Kitakaze, Tetsuo Minamino, Kazuo Komamura, Mitsuaki Chujo, Hidezo Mori, Michihiko Tada, Michitoshi Inoue, Masatsugu Hori, Takenobu Kamada
Journal: Journal of the American College of Cardiology (1995)
Case 36-1981
Authors: Richard C. Cabot, Robert E. Scully, Eugene J. Mark, Betty U. McNeely, Herbert T. Abelson, Nancy L. Harris
Journal: New England Journal of Medicine (1981)

Presentation of CaseA 10-year-old girl was admitted to the hospital because of pain in the shoulder.She was well until two months earlier, when right mastoiditis was treated with amoxicillin; a right myringotomy was performed, and serosanguineous drainage was noted. One month before entry pain developed in the right shoulder and upper arm, with local swelling and tenderness; the temperature rose to 37.6°C. A blood count and an x-ray film of the right shoulder, performed elsewhere, were normal. Aspirin was administered, with improvement. Two weeks later pain recurred in the right shoulder and arm, and she complained of pain . . .
Targeting Vascular Endothelial Growth Factor in Patients With Squamous Cell Lung Cancer
Authors: Peter J. Koo, Daniel Morgensztern, Julie L. Boyer, Roy S. Herbst
Journal: Journal of Clinical Oncology (2012)

Article Tools UNDERSTANDING THE PATHWAY Article Tools OPTIONS & TOOLS Export Citation Track Citation Add To Favorites Rights & Permissions COMPANION ARTICLES No companion articles ARTICLE CITATION DOI: 10.1200/JCO.2011.40.4053 Journal of Clinical Oncology - published online before print February 21, 2012 PMID: 22355057 Targeting Vascular Endothelial Growth Factor in Patients With Squamous Cell Lung Cancer Peter J. KooxPeter J. KooSearch for articles by this author , Daniel MorgenszternxDaniel MorgenszternSearch for articles by this author , Julie L. BoyerxJulie L. BoyerSearch for articles by this author , Roy S. HerbstxRoy S. HerbstSearch for articles by this author Show More Yale Comprehensive Cancer Center, Yale University School of Medicine, New Haven, CT https://doi.org/10.1200/JCO.2011.40.4053 First Page Full Text PDF Figures and Tables © 2012 by American Society of Clinical Oncology
Lead alters the immunogenicity of two neural proteins: a potential mechanism for the progression of lead-induced neurotoxicity.
Authors: S J Waterman, H A el-Fawal, C A Snyder
Journal: Environmental Health Perspectives (1994)

Some heavy metals have been suspected of playing a role in the pathogenesis of nervous system diseases such as multiple sclerosis, amyotrophic lateral sclerosis, and Alzheimer's disease. In these disorders, autoantibodies against neural proteins are evident at some stage of the disease. Lead is known to affect both the immune and nervous systems. Work in our laboratory has shown that lead exposure leads to the production of autoantibodies against neural proteins, including myelin basic protein (MBP) and glial fibrillary acidic protein (GFAP). We hypothesize that lead aggravates neurological disease by enhancing the immunogenicity of nervous system proteins, including MBP and GFAP. To test this hypothesis, lead-altered protein was prepared by incubating MBP or GFAP with lead acetate for 24 hr. On days 0, 14, and 28, mice received inoculations with either saline, native protein, or lead-altered protein. Anti-MBP and anti-GFAP, isotypes IgM and IgG, were measured in sera by ELISA on day 38. Sera of mice treated with lead-altered MBP had statistically higher anti-MBP IgG titers than both control and native MBP-immunized mice. An analogous response was seen in mice immunized with lead-altered GFAP. Supernatants from lectin-stimulated splenocytes were also examined for antibody titers and for interleukin 2 (IL-2) and interleukin 6 (IL-6) levels. A significant increase in IL-6 production was seen in mice immunized with lead-altered MBP but not with lead-altered GFAP. No changes were observed in the IL-2 levels of mice immunized with either lead-altered protein.(ABSTRACT TRUNCATED AT 250 WORDS)
Grime and punishment
Authors: B. Britchford
Journal: BMJ (1995)

I work in the NHS. Dirt and ugliness pervade my working world. Ceilings leak, carpets curl, paint flakes, and the NHS goes on: providing a good service despite the surroundings. Why do other countries greet patients at medical facilities with cleanliness, comfort, and clean lines while Britain's hospitals continue to portray an air of destitution and decay?

For example, I sit one day a week, posing—or so it feels—as a consultant child psychiatrist, in a staff rest room. It is 3.5 m by 2.5 m and contains seven stained fabric chairs and a fridge where the staff of the centre keep their milk and their yoghurt. Half the time I have been working there—seven months—a pneumatic drill has been barping or keening outside the window. For two days a pile driver shook the whole building adding a new type of emphasis to my family therapy. There is a glass door, so that anyone who cares to look can see who is seeing the psychiatrist today.

Another clinic where I have …
TCT-848 Mynx™ Vascular Closure Device Achieves Reliable Closure and Hemostasis of Large Bore Percutaneous Trans-Femoral Venous Access in a Porcine Vascular Model: Acute and 30 Day Evaluation using Angiography, Ultrasound, and Histology
Authors: sanjay s srivatsa, Arjun Srivatsa, Taylor Spangler
Journal: Journal of the American College of Cardiology (2014)
Seasonal Onset of Acute Leukaemia
Authors: T. M. Allan
Journal: BMJ (1964)

ments now taking place in this continent, significant differences are becoming obscured.It is suggested that details of the transfusion services throughout Africa should be col- lected and made available in pamphlet form to each co-operating service and to workers overseas who might be interested in having this information.This simple project should *prove to be of particular interest to those -workers who will be engaged in the Inter--national Biological Programme which will be ,commencing shortly.May I request, through the agency of your journal, that any transfusion service in Africa should send me the following information:(1) title of service; (2) address; (3) name of medical director; (4) area or region served; and (5) name of the responsible authority.It is hoped to obtain at least one address for each country.
Clinical Studies with an Intragastric Camera.
Authors: John F. Morrissey
Journal: Annals of Internal Medicine (1965)

s1 May 1965Clinical Studies with an Intragastric Camera.John F. Morrissey, M.D. (Associate), Giuseppe Perna, M.D., Toshio Honda, M.D.John F. Morrissey, M.D. (Associate)Search for more papers by this author, Giuseppe Perna, M.D.Search for more papers by this author, Toshio Honda, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-62-5-1079_3 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe results of over 500 examinations performed with the Type V Japanese gastrocamera will be described. A comparison will be made between the gastrocamera, gastroscope, and barium meal X ray for the diagnosis of gastric pathology.The gastrocamera consists of a small intragastric camera containing an 80-deg wide angle lens, flashlamp, film capsule, and air valve which is attached to an external control unit by a 75-cm vinyl covered tube. The camera is positioned in the stomach by observing the light of the tungsten flash through the abdominal wall. Films are taken in a prescribed pattern with emphasis given to... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: John F. Morrissey, M.D. (Associate); Giuseppe Perna, M.D.; Toshio Honda, M.D. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 May 1965Volume 62, Issue 5Page: 1079-1079KeywordsGastroenterology and hepatologyStomach ePublished: 1 December 2008 Issue Published: 1 May 1965 PDF downloadLoading ...
Letting vegetative patients die.
Authors: K. Andrews
Journal: BMJ (1992)

tantalisingly useful literature not readily available in any British library, from such titles as the Indiaii ]ooroal of Oplhthalniology or J7ounmal of tze Teoenessee Medical Associatioo.Photocopying?Marvellous invention!Never has so much been copied by so many but, I suggest, used by so few.Beware the siege mentality that requires a copy when, previously, reading, digest- ing, and a few notes would have sufficed.Copyright?Hideous piece of legislation, but, sadly, ours was the lone voice against it as it went through parliament and we are left with the unenviable task of making its impracticalities work.As for licences, Drife is presumably referring to higher education: negotiations between the
Colistin—A Reappraisal
Authors: Robert G. Petersdorf, James J. Plorde
Journal: JAMA (1963)

COLISTIN, a polypeptide antibiotic closely related to polymyxin B, has been in use in the United States for approximately three years. Despite the accumulation of considerable clinical experience with this agent, it is still subject to a good deal of controversy. Three topics are at issue: (1) Is colistin actually superior to polymyxin B with respect to antibacterial activity, therapeutic efficacy, and relative lack of toxicity? (2) What is the toxic potential of colistin; is it, in fact, as nontoxic to the kidneys as claimed in some enthusiastic early reports? (3) Should this agent become the drug of choice in gram negative infections, particularly before sensitivity tests are available? It is the purpose of this brief communication to analyze some aspects of these problems and to offer some tentative conclusions. There is little question but that the sulfate salts of both colistin and polymyxin B have remarkably similar activity
C3 glomerulonephritis: clinicopathological findings, complement abnormalities, glomerular proteomic profile, treatment, and follow-up
Authors: Sanjeev Sethi, Fernando C. Fervenza, Yuzhou Zhang, Ladan Zand, Julie A. Vrana, Samih H. Nasr, Jason D. Theis, Ahmet Dogan, Richard J.H. Smith
Journal: Kidney International (2012)
Tolerance of intravenous indomethacin treatment for premature infants with patent ductus arteriosus.
Authors: M. Walters
Journal: BMJ (1988)

eight patients who had a stable or partial response, suggesting that, in addition to causing sclerosis of bone, APD may have an antitumour effect.Factors released from tumours stimulate osteoblastic activity3 and osteolysis mediated by osteoclasts.4APD is a potent inhibitor of osteoclast function, and such inhibition combined with the osteoblastic factors produced by tumour cells may explain the bony sclerosis seen in this study.APD reduces morbidity from lytic metastases when used in conjunction with standard chemotherapy,' and this study shows that it may be active when used alone.We are grateful to the staff of the day ward, Christie Hospital; the departments of chemical pathology at Christie Hospital and Withington Hospital; Mrs H Morten and Mr J Turnbull for performing the radioimmunoassays; and Ciba-Geigy Ltd for supplies of APD and for financial support.
Metabolic Effects of Bariatric Surgery in Patients With Moderate Obesity and Type 2 Diabetes
Authors: Sangeeta R. Kashyap, Deepak L. Bhatt, Kathy Wolski, Richard M. Watanabe, Muhammad Abdul-Ghani, Beth Abood, Claire E. Pothier, Stacy Brethauer, Steven Nissen, Manjula Gupta, John P. Kirwan, Philip R. Schauer
Journal: Diabetes Care (2013)

To evaluate the effects of two bariatric procedures versus intensive medical therapy (IMT) on β-cell function and body composition.This was a prospective, randomized, controlled trial of 60 subjects with uncontrolled type 2 diabetes (HbA1c 9.7 ± 1%) and moderate obesity (BMI 36 ± 2 kg/m(2)) randomized to IMT alone, IMT plus Roux-en-Y gastric bypass, or IMT plus sleeve gastrectomy. Assessment of β-cell function (mixed-meal tolerance testing) and body composition was performed at baseline and 12 and 24 months.Glycemic control improved in all three groups at 24 months (N = 54), with a mean HbA1c of 6.7 ± 1.2% for gastric bypass, 7.1 ± 0.8% for sleeve gastrectomy, and 8.4 ± 2.3% for IMT (P < 0.05 for each surgical group versus IMT). Reduction in body fat was similar for both surgery groups, with greater absolute reduction in truncal fat in gastric bypass versus sleeve gastrectomy (-16 vs. -10%; P = 0.04). Insulin sensitivity increased significantly from baseline in gastric bypass (2.7-fold; P = 0.004) and did not change in sleeve gastrectomy or IMT. β-Cell function (oral disposition index) increased 5.8-fold in gastric bypass from baseline, was markedly greater than IMT (P = 0.001), and was not different between sleeve gastrectomy versus IMT (P = 0.30). At 24 months, β-cell function inversely correlated with truncal fat and prandial free fatty acid levels.Bariatric surgery provides durable glycemic control compared with intensive medical therapy at 2 years. Despite similar weight loss as sleeve gastrectomy, gastric bypass uniquely restores pancreatic β-cell function and reduces truncal fat, thus reversing the core defects in diabetes.
Changes in fitness profiles during a season of track and field training and competition.
Authors: V. Thomas, T. Reilly
Journal: British Journal of Sports Medicine (1976)

cording to Thomas (1 973).4. Psychological measures:- (a) Vision (i) distance perception (distance) and (ii) Stereopsis, obtained by means of the Keystone ophthalmic telebinocular.(b) Visual reaction time (RT) according to Teichnerand Krebs (1972) obtained using a Heuer chro- noscope.
Pharmacotherapy in the Management of Obesity
Authors: Michael Steelman
Journal: JAMA (1997)

Although the article<sup>1</sup>on pharmacotherapy for obesity was an excellent review, 2 statements in that article deserve additional comment. First, the authors indicate, "The use of these medications was widespread and often indiscriminate." This statement is typical of disparaging comments offered in review articles on obesity treatment. Without statistical or numerical validation, such pronouncements are difficult to interpret. What, specifically, do the terms "widespread" and "indiscriminate" mean? The authors use as a reference for this statement an article<sup>2</sup>that stated, "Amphetamine, however, suffers from the serious disadvantage of having a substantial abuse<i>potential</i>" (emphasis added). There is a considerable difference between the phrases "substantial abuse potential" and "widespread and indiscriminate use." As opposed to class II amphetamines, are there data to indicate that abuse of the class III and IV anorexigenics is or has been widespread or indiscriminate? Second, the authors state, "Until more data are available, pharmacotherapy cannot
Tape Recordings of the ECG of Active Men
Authors: LAWRENCE E. HINKLE, JEROME MEYER, MICHAEL STEVENS, SUSAN T. CARVER
Journal: Circulation (1967)

The electronic and mechanical characteristics of the Holter-Avionics instruments for recording and analyzing the electrocardiogram of active men have been measured in the laboratory, and during carefully standardized 6-hour recordings of 385 active subjects. Although late model recorders have a cumulative timing error of less than 1%, the frequency response of the system is limited at both the upper and lower ends of the range, producing significant distortion of the complex. Scanning the taped data at 60 times real-time is a helpful screening procedure, but accurate analysis of records requires photographic write-out of R-R intervals with real-time scanning and analysis of all potential areas of abnormality. If records are made with subjects under constant observation and stop-watch timed, they can yield significant data on phenomena of rate, rhythm, and conduction, under a variety of circumstances and over long periods of time; but changes in the shape of the ST segment and T wave must be interpreted with great caution because of distortions produced by the recording system and by changes in position and activity.