tbuckley/cabot-search huggingface dataset:
Abstract 17913: Linear Relationship Between Seattle Heart Failure Model Predicted Mortality and Hospitalizations in Patients with Chronic Heart Failure
Authors: Alec J Moorman, Piotr Ponikowski, Stefan D Anker, Guillermo Torre-Amione, James B Young, Wayne C Levy
Journal: Circulation (2011)

Background Acute heart failure (HF) is a common and costly reason for hospitalization worldwide. We assessed the relationship between Seattle Heart Failure Model-D (SHFM-D) predicted mortality, total hospital days per year and discrete hospitalizations per year using data from the international Advanced Chronic Heart Failure Clinical Assessment of Immune Modulation Therapy (ACCLAIM) trial. We hypothesized a linear relationship between SHFM-D predicted mortality and annual hospitalizations and days hospitalized. Methods and Results 2407 chronic HF subjects with a total of 1023 all-cause hospitalizations and 430 HF hospitalizations were grouped by SHFM-D score. There was a linear relationship between SHFM-D estimated mortality and all-cause and HF hospitalizations per year, and all-cause and HF hospital days per year. For each 10% increase in SHFM-D predicted mortality, there were approximately 8 additional all-cause hospital days per year and 5 additional HF hospital days per year (Figure 1), and 0.7 additional all-cause hospitalizations per year and 0.5 additional HF hospitalizations per year (Figure 2). The SHFM-D score also predicted the primary and secondary ACCLAIM endpoints: composite of death or cardiovascular hospitalization (AUC 0.63, 95% CI 0.61-0.66, p &lt; 0.001), death or worsening heart failure hospitalization (AUC 0.69, 95% CI 0.66-0.71, p &lt; 0.001), and all-cause death (AUC 0.73, 95% CI 0.69-76, p &lt; 0.001). Conclusions In the ACCLAIM cohort of patients with chronic systolic HF, there is a linear relationship between SHFM-D predicted mortality and annual hospitalizations and total days hospitalized.
Abstract 5816: Lumen Augmentation Induced by Lipid Lowering Therapy is Associated with Greater Regional Left Ventricular Function by Speckle Tracking Echocardiography
Authors: Veronica R Fernandes, Boaz D Rosen, Gustavo Godoy, Thomas Helle-Valle, Christopher Sibley, Elzbieta Chamera, David A Bluemke, Joao A Lima
Journal: Circulation (2008)

Introduction: Aortic magnetic resonance imaging (MRI) can monitor plaque regression and lumen augmentation in patients undergoing treatment for advanced atherosclerosis. However, the relationship of reduced aortic plaque burden to regional left ventricular (LV) function is unknown.  Methods: 71 patients (54 males) > 65 years of age underwent MRI measurements of descending aortic lumen and plaque size obtained from axial images of the thoracic aorta by 1.5 T MRI at baseline and after 18 months of lipid lowering therapy, using T1-weighted images (after 0.1 mmol/kg of intravenous gadodiamide). All participants underwent speckle tracking echocardiography (STE) to evaluate regional LV function at 18 months.  Results: 35 patients (26 male, 35%) had an increase in aortic lumen diameter (atherosclerotic plaque burden decreased) after 18 months. These patients had greater regional LV function compared to patients who had reduction of the aortic luminal diameter (circumferential strain ECC antero septal=−21.9 and −16.6%, septum=−18.6 and −13.6, global Ecc= −16.4 and −12.5%, respectively, p
Abstract 14734: The Importance of Right Ventricular Function in Survival Following Cardiac Resynchronisation Therapy
Authors: Darryl P Leong, Ulas Hoke, Dominique Auger, Tomosz G Witkowski, Joep Thijssen, Lieselot van Erven, Victoria Delgado, Martin J Schalij, Jeroen J Bax, Nina Ajmone Marsan
Journal: Circulation (2011)
Second-Generation Everolimus-Eluting Stents Versus First-Generation Sirolimus-Eluting Stents in Acute Myocardial Infarction
Authors: Sjoerd H. Hofma, Jan Brouwer, Matthijs A. Velders, Arnoud W.J. van't Hof, Pieter C. Smits, Michel Queré, Cornelis Jan de Vries, Adrianus J. van Boven
Journal: Journal of the American College of Cardiology (2012)
Abstract 2744: Left Atrial Appendage: An Undercognized Trigger Site of Atrial Fibrillation
Authors: Luigi Di Biase, J. David Burkhardt, Rodney Horton, Javier Sanchez, Shane Bailey, Prasant Mohanty, Dimpi Patel, Steven Hao, Richard Hongo, Salwa Beheiry, Amin Al-Ahamad, Paul Wang, Michela Casella, Pietro Santarelli, Gemma Pelargonio, Antonio Dello Russo, Andrea Natale
Journal: Circulation (2009)
Abstract 9111: The Summation of ST-Segment Elevation is a Novel Predictor for Complications in Patients with Stress (Takotsubo) Cardiomyopathy
Authors: Seiji Takashio, Megumi Yamamuro, Sunao Kojima, Ryusuke Tsunoda, Koichi Nakao, Hisao Ogawa
Journal: Circulation (2011)

Background: Although the prognosis of stress (Takotsubo) cardiomyopathy (SC) is relatively favorable, it sometimes leads to serious complications. It is generally accepted that electrocardiogram (ECG) highly suggestive of the characteristics of myocardial damage is essential tool for diagnosis of SC. We assessed the hypothesis that serial change and quantitative analysis of ECG are associated with following adverse events in patients with SC. Methods and Results: The study patients consisted of 85 patients with SC. A total of 34 patients suffered from 1 or more in-hospital adverse events such as heart failure, intraventricular pressure gradient (&gt;30 mmHg), cardiogenic shock, ventricular tachycardia/fibrillation, and cerebral embolism. Of them, 2 patients died of cardiogenic shock. Patients with adverse events had higher heart rate (96±25 vs. 76±17 bpm, p&lt;0.001) and greater summation of ST-segment elevation in 12 leads (ΣSTE) (10.5 [5.0 to 17.5] mm vs. 3.0 [0 to 7.0] mm; p&lt;0.001) than those with non-adverse event. A multivariate logistic regression analysis showed that heart rate and ΣSTE were independent predictive variables (Table) and the best cutoff level of ΣSTE for prediction of adverse events was 5.5 mm based on a receiver operating characteristic curve. The ST-segment elevation in adverse events group extended up to limb leads as well as precordial leads compared with that in non-adverse evnets group (50% vs. 12%; p&lt;0.001). However, a significant difference was not observed regarding ST resolution &lt;50% at 24 hour after hospital admission clinically suggestive of prognostic impairment of SC between 2 groups (38% vs. 43%; p=0.80). Conclusions: Electrocardiographic extent and magnitude of ST-segment elevation can predict in-hospital adverse events following SC. Our findings may help to explain the missing link between ECG changes and the severity of catecholamine-induced myocardial damage deeply involved in fatal and non-fatal complications.
慢性腹痛-发热-肠梗阻
Authors: 赵久良, 吴东, 孙晓红, 方秀才, 朱峰
Journal: BMJ (2010)

患者女,24岁,主诉间断腹痛、发热伴体重下降1年.2008年8月患者无明显诱因出现中上腹部疼痛,为阵发性隐痛,伴发热,体温最高38.5℃,无烧心、反酸、恶心、呕吐等,无腹泻、黑便及黏液脓血便.发病以来体重下降15 kg。
Airline passenger dies after being sedated
Authors: H A Macdonald, M S. Abdalla
Journal: BMJ (1999)

Editor—Kovac describes how a disturbed man on a plane who had probably taken drugs and alcohol died after being restrained and given intravenous sedation with diazepam.1 This would appear to have been a classic example of positional asphyxia, which is well known to police and custodial services world wide. The cardinal features are disturbed behaviour usually in combination with drugs or alcohol, or both, and compression of the chest, usually to restrain individuals. It is well documented both in medical and police literature.2–4
Abstract 3806: Augmented Creatine Kinase Expression Attenuates the Decline in In Vivo Energetics and Contractile Function in Pressure-Overload Hearts
Authors: Mikhail Maslov, Hunter Champion, Vadappuram Chacko, Lili Wang, Gary Gerstenblith, Robert Weiss
Journal: Circulation (2008)

Purpose: The creatine kinase (CK) reaction is the primary energy reserve of the heart and a rapid ATP source for the contractile elements. In patients and animal models, pressure-overload results i...
503 NOVEL REVERSE TRANSCRIPTASE MUTATIONS SPECIFICALLY ASSOCIATED WITH SELECTED ANTI-HBV TREATMENT CAN INDUCE ALTERATIONS AND STOP-CODONS IN HBV S ANTIGEN
Authors: V. Cento, F. Van Hemert, V.C. Di Maio, R. Salpini, C. Mirabelli, A. Bertoli, C. Gori, V. Micheli, G. Gubertini, R. Longo, S. Romano, M. Visca, G.M. De Sanctis, N. Marino, F. Mazzotta, G. Cappiello, C. Sarrecchia, F. Ceccherini-Silberstein, M. Andreoni, M. Angelico, C.F. Perno, V. Svicher
Journal: Journal of Hepatology (2012)
John Bruce Bittiner Amelie Boyd David Christy Dunn Judith Anne Hardy Leonard Shenfield
Authors: B. Bittiner, J. Boyd, R. Boyd, S. Boyd, a. R. Boyd, M. Lindop, S J Shribman, J. Lister
Journal: BMJ (1998)

q Aberdeen 1943), died from cancer of the pancreas on 30 May 1998.He served with the Royal Army Medical Corps in India when newly qualified and returned to England to finish his training.He published the first described cases of asymptomatic carriage of gonorrhoea in men in 1955.He delighted in teaching medical students, nurses and midwives, and doctors, and this skill was aided by a rapport for young people and an impish sense of humour.He took great pride in his department, his staff, and the hospital, and in 1990 published Nottingham General Hospital-Personal Reflections.In the early 1960s he predicted the changes caused by the sexual revolution and the contraceptive pill, which were to alter the demography of the clinics from a domination by men to virtual parity of men and women.At the same time effective antibiotics and contact tracing put the traditional sexually transmitted diseases, such as gonorrhoea and syphilis, into decline.He became chairman of the Nottingham Stroke Appeal, which culminated in the establishment of a chair in stroke medicine and an associated research unit.In retirement he pursued his many interests, including horticulture, motor caravanning, and art classes.He leaves a wife, Pauline; two sons and a daughter; and eight grandchildren.[Bruce Bittiner]
Abstract 2231: Thoracic Aortic Calcification and Coronary Heart Disease Events: the Multi-Ethnic Study of Atherosclerosis (MESA)
Authors: Matthew J Budoff, Khurram Nasir, Ronit Katz, Junichiro Takasu, J Jeffrey Carr, Nathan D Wong, Matthew Allison, Joao A Lima, Robert Detrano, Roger S Blumenthal, Richard Kronmal
Journal: Circulation (2008)

Background: The presence of coronary artery calcium (CAC) is an independent marker of cardiovascular disease (CVD) events and mortality. However, the predictive value of thoracic aorta calcification (TAC), which can be additionally examined without further scanning during assessment of CAC, in predicting coronary heart disease (CHD) events in asymptomatic women and men, is not well-established. Methods: We collected data on risk factors and performed scanning for both TAC and CAC in a multi-ethnic population-based cohort of 6809 individuals (62±10 years, 47% males). Using the same images for each participant, TAC and CAC were computed using the Agatston method. The study subjects had no clinical cardiovascular disease at entry and were followed for a median of 4.1 years. Results: The mean age of the study population was 62±10 years (47% males). At baseline 1904 (28%) participants had detectable TAC, whereas 3392 (50%) had CAC&gt;0. During the follow-up interval, 189 (2.78%) and 108 (1.59%) participants suffered any CHD and hard CHD event, respectively. Table below provide the hazard ratio (95% CI) for coronary events with presence of TAC. Overall TAC was a stronger predictor of CHD risk in women than in men. . Conclusion: Our study result suggests that TAC imparts independent prognostic power to predict future coronary events in women and may provide rationale for more intensive risk factor modification. Hazard Ratios (95% CI) of All CHD and Hard CHD Events with TAC (TAC&gt;0 vs. TAC=0)
Abstract 709: Encapsulation Of A Small Molecule p38 Inhibitor For Cardiac Regeneration
Authors: Jay C Sy, Gokulakrishnan Iyer, Sergey Dikalov, Niren Murthy, Michael E Davis
Journal: Circulation (2007)

Myocardial dysfunction is usually progressive and successful therapy will likely require sustained delivery. Small molecule inhibitors have great clinical potential in the treatment of cardiac dise...
Abstract 159: Remote Ischemic Postconditioning in Direct Post--Cardiac Arrest Period: An Animal Study
Authors: Matthias Gruenewald, Ole Broch, Martin Albrecht, Florian Krauss, Tim Sczibilanski, Berthold Bein, Patrick Meybohm
Journal: Circulation (2011)

Background: The global ischemia/reperfusion injury induced by cardiac arrest is one main cause for the limited survival after successful resuscitation [1]. Recently, remote ischemic post-conditioni...
Abstract 2005: Effect of Intravenous Iron Sucrose on Exercise Tolerance in Anemic and Non-anemic Patients with Symptomatic Chronic Heart Failure and Iron Deficiency: A Randomised, Controlled, Observer-blinded Trial (FERRIC-HF)
Authors: Darlington O Okonko, Agnieszka Grzeslo, Tomasz Witkowski, Amit K Mandal, Robert M Slater, Gabor Foldes, Waldemar Banasiak, Constantinos G Missouris, Philip A Poole-Wilson, Stefan D Anker, Piotr Ponikowski
Journal: Circulation (2006)
Abstract 8406: The Addition of Direct Renin Inhibitor Aliskiren to Standard Therapy Suppresses Enhanced Cardiac Sympathetic Activity in Patients with Systolic Heart Failure
Authors: Imamura Yoshihiro, Tsutumi Takaki, Yamada Akira
Journal: Circulation (2011)

Introduction: Aliskiren, direct rennin inhibitor, decreases plasma brain natriuretic peptide (BNP) concentrations in patients with heart failure (HF). However, the effect of aliskiren on cardiac sympathetic nerve function is unclear. Hypothesis and Objectives: We examined the effects of aliskiren on neurohormonal function when added to standard therapy in patients with systolic HF, under the hypothesis that aliskiren therapy would affect sympathetic nerve function. Methods: We enrolled 34 patients with HF due to systolic dysfunction (LVEF of &lt;45%), receiving standard therapy including an angiotensin-converting-enzyme inhibitor or angiotensin-receptor blocker and a beta-blocker. We randomly assigned 17 patients to receive additional aliskiren treatment 150 mg/d (aliskiren group), while 17 patients continued standard therapy (control group). All patients underwent neurohormonal measurements and planar 123 I-metaiodobenzylguanidine (MIBG) imaging. In the MIBG images, the heart/mediastinum (H/M) ratio and cardiac washout rate (WR) were determined for evaluating cardiac sympathetic activity. The follow-up data was obtained three months later. Results: There were no significant changes in the hemodynamics in either group. In the aliskiren group, plasma renin activity fell and concomitantly, the WR decreased and H/M ratio increased during the follow-up period (WR: 39.4 ± 13.3 % to 32.9 ± 9.2 %, p = 0.009, H/M: 2.84 ± 0.68 to 3.13 ± 0.77, p = 0.016). In addition, BNP fell from 150.7 ± 102.3 pg/mL to 99.9 ± 70.5 pg/mL (p=0.001). We found a significant negative correlation between the change in WR and the baseline PRA in the aliskiren group (r = - 0.64, p = 0.004). This correlation suggests that inhibition of the circulating renin activity might be possible mechanism for sympatho-inhibitory effects by aliskiren. In the control group, MIBG imaging findings and plasma BNP concentration remained unchanged. Conclusions: The addition of aliskiren to standard therapy led to renin-angiotensin-aldosterone system inhibition, which subsequently led to the suppression of enhanced cardiac sympathetic activity and a decrease in plasma BNP concentrations in patients with systolic HF.
心力衰竭（一）历史和流行病学
Authors: 严红, Davis, Rc
Journal: BMJ (2001)

心力衰竭 (心衰 )是所有心脏疾患的终末阶段 ,且是并发其他疾病和死亡的一个重要原因。在英国 ,据估计它约占医院内科住院数的 5% ,每年住院人数超过 10 0 0 0 0人。心衰总的患病率为每千人中 3～ 2 0例 ,不过 ,在6 5岁及以上年龄的人口中 ,超过 10 0例。心衰的年度发病率为每千人中 1～ 5例 ,而在 4 5岁以后 ,年龄每增加 10岁 ,相对发病率就增加 1倍。其总发病率在未来可能还会升高 ,这是由于人口的老龄化以及急性心肌梗死处理的进展 ,使有心脏功能受损的患者生存率得到改善所致。由于心衰的很多临床特征都不具有器官特异性 ,且在它的早期阶段 ,临床征象可能很少 ,因此
Review of Hilde Lindemann, <i>Holding and Letting Go: The Social Practice of Personal Identities</i><sup>1</sup>
Authors: John Christman
Journal: The American Journal of Bioethics (2015)

"Review of Hilde Lindemann, Holding and Letting Go: The Social Practice of Personal Identities1." The American Journal of Bioethics, 15(8), pp. W8–W9
Abstract 17817: Impact of Aldose Reductase on Endothelial Function and Vascular Insulin Resistance in Diet-Induced Obesity
Authors: Petra Haberzettl, Jason Hellmann, Ishan Mehta, Aruni Bhatnagar, Daniel J Conklin
Journal: Circulation (2010)

Obesity is a major risk factor for the development of type 2 diabetes and cardiovascular disease. It is associated with the induction of low grade inflammation that leads to insulin resistance and ...
Abstract 3354: Increase of Telomere Gap between Granulocytes and Lymphocytes in Patients with Previous Myocardial Infarction: A Novel Measure for Accelerated Telomere Erosion
Authors: Ioakim Spyridopoulos, Young Erben, Tim H Brummendorf, Judith Haendeler, Florian Seeger, Christine Kissel, Hans Martin, Jedrzej Hoffmann, Birgit Assmus, Andreas M Zeiher, Stefanie Dimmeler
Journal: Circulation (2007)

Individuals with age-corrected reduction of total leukocyte telomere length have been shown to exhibit a remarkable increase in mortality from cardiovascular and infectious complications. Given the considerable interindividual variability of telomere length in healthy adults due to genetic differences already present at birth and the heterogeneity in composition of the total leukocyte compartment, extensive study populations are required to detect accelerated telomere shortening between age-matched groups. With this study, we intended to identify a parameter to improve prediction of individual telomere erosion in patients (pts) with coronary artery disease and previous myocardial infarction (CAD). Methods: Mean telomere length (mTL) was measured in 63 CAD pts (mean age 65±4 years, mean ejection fraction 31±9%) and 23 age-matched healthy controls (65±4 years). Using the flow-FISH method, we were able to distinguish between myeloid and lymphoid cell populations in peripheral blood cells as well as in bone marrow mononuclear cells (BMC). Results: The difference between mTL of the granulocyte and lymphocyte population (ΔTEL Gr-Ly ) was significantly increased from 742 ± 396 base pairs (bp) in the control group to 1055±570 bp in CAD pts (p=0.018). Age was the only independent predictor for telomere length of BMCs. Lymphocytes, but not granulocytes, demonstrated significant telomere shortening between BMCs and peripheral blood in CAD patients (−444 ± 624 bp) as opposed to an increase in a young and healthy control group (+307 ± 372 bp) (p&lt;0.001). Using immunomagnetic cell sorting, telomerase activity (TA) was determined in freshly isolated white blood cell subpopulations. Surprisingly, TA could not be detected in peripheral blood granulocytes (CD15 + granulocytes) from CAD pts. In contrast, CD4 + T-lymphocytes contained the highest amount of TA, compared to CD8 + cells and B-lymphocytes. Conclusions: Our results suggest that primarily peripheral blood lymphocytes - and not granulocytes - can develop stress-induced telomere erosion in CAD. Therefore the base pair length difference between the two populations provides a valuable parameter to detect telomere erosion in patients with CAD, largely independent of the hereditary influence on mTL.
Canalicular membrane MRP2/ABCC2 internalization is determined by Ezrin Thr567 phosphorylation in human obstructive cholestasis
Authors: Jin Chai, Shi-Ying Cai, Xiaocong Liu, Wei Lian, Sheng Chen, Liangjun Zhang, Xinchan Feng, Ying Cheng, Xiaochong He, Yu He, Lei Chen, Rongquan Wang, Huaizhi Wang, James L. Boyer, Wensheng Chen
Journal: Journal of Hepatology (2015)
The Physician as Public Health Professional in the 21st Century
Authors: Stephen M. Shortell, John Swartzberg
Journal: JAMA (2008)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Abstract 20649: Optimal Medical Therapy Use Among Implantable Cardioverter-Defibrillator Recipients: Insights from the NCDR ICD Registry
Authors: Amy L Miller, Yongfei Wang, Jeptha Curtis, Frederick A Masoudi, Alfred E Buxton, Tracy Yu-Ping Wang
Journal: Circulation (2010)

Background: Current guideline recommendations for implantable cardioverter-defibrillators (ICD) in patients with left ventricular systolic dysfunction presuppose that such patients are receiving op...
Assessment of Myocardial Viability in Chronic Coronary Artery Disease Using Technetium-99m Sestamibi SPECT:
Authors: Alex F Maes, Marcel Borgers, PhD, Willem Flameng, Johan L Nuyts, Frans van de Werf, Jannie J Ausma, Paul Sergeant, Luc A Mortelmans
Journal: Journal of the American College of Cardiology (1997)
The Use Of Donor Lymphocyte Infusion (DLI) For Relapse After Related T-Cell Replete HLA-Haploidentical Bone Marrow Transplantation (haploBMT) With Posttransplantation Cyclophosphamide (PTCy)
Authors: Amer M. Zeidan, Patrick Forde, Heather J. Symons, Allen R. Chen, B. Douglas Smith, Ephraim J. Fuchs, Leo Luznik, Richard J. Jones, Javier Bolaños-Meade
Journal: Blood (2013)
Abstract 11612: Ablation of Angiotensin IV Receptor (AT4R) Augments Angiotensin II-Induced Myocardiac Fibrosis and Cardiac Dysfunction
Authors: Yasushi Numaguchi, Masakazu Ishii, Manabu Niwa, Megumi Kondo, Sonomi Maruyama, Rei Shibata, Toyoaki Murohara
Journal: Circulation (2011)

The angiotensin II (Ang II)-AngII receptor type1 (AT1R) axis plays a key role in cardiac inflammation and fibrosis in chronic heart diseases. Insulin-regulated aminopeptidase (IRAP), a pleiotropic ...
Antineoplastons
Authors: 徐文方, 王厚全
Journal: CA A Cancer Journal for Clinicians (1983)

UnprovenMethodsof CancerManagement AntineoplastonsAfter careful study of the literature and other information available to it, the Amer ican Cancer Society does not have evi dence that treatment with antineoplastons results in objective benefit in the treatPnent of cancer in human beings.Lacking such evidence, the American Cancer Society would strongly urge individuals afflicted with cancer not to participate in treat@nent with antineoplastons.