Meningitis and Skin Reaction after Intravenous Immune Globulin Therapy
Authors: Benoit Catteau
Journal: Annals of Internal Medicine (1997)

Letters15 December 1997Meningitis and Skin Reaction after Intravenous Immune Globulin TherapyBenoit Catteau, Emmanuel Delaporte, and Frederic PietteBenoit CatteauUniversity Hospital Center Lille; 59037 Lille Cedex, FranceSearch for more papers by this author, Emmanuel DelaporteUniversity Hospital Center Lille; 59037 Lille Cedex, FranceSearch for more papers by this author, and Frederic PietteUniversity Hospital Center Lille; 59037 Lille Cedex, FranceSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-127-12-199712150-00021 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:We read with interest the article by Dalakas on IVIg therapy in neurologic diseases, especially the section on skin reactions [1]. We observed a cutaneous reaction to IVIg, clinically typical of pompholyx, in two male patients. These patients were 34 and 61 years of age and were treated for the Guillain-Barre syndrome and chronic inflammatory demyelinating polyneuropathy, respectively, with IVIg (0.4 g/kg of body weight over 5 days).One patient developed nonpruritic palmoplantar vesicular lesions 5 days after the start of therapy. The other had slightly pruritic erythema and vesicles on the lateral aspects of the fingers ...References1. Dalakas MC. Intravenous immune globulin therapy for neurologic diseases. Ann Intern Med. 1997; 126:721-30. Google Scholar2. Zurcher K, Krebs A. Cutaneous Drug Reactions: An Integral Synopsis of Today's Systemic Drugs, with Drug Tables and Sign/Symptom Tables. 2d ed. Basel: Karger; 1992:246-7. Google Scholar3. Barucha C, McMillan JC. Eczema after intravenous infusion of immunoglobulin. Br Med J. 1987; 295:1141. Google Scholar4. Mackenzie D, Vlahcevic ZR. Adverse reaction to gammaglobulin due to hypersensitivity to thiomersal. N Engl J Med. 1979; 290:749. Google Scholar5. Crosti C, Lodi A. Pompholyx: a still unresolved kind of eczema. Dermatology. 1993; 186:241-2. Google Scholar Author, Article, and Disclosure InformationAuthors: Benoit Catteau; Emmanuel Delaporte; Frederic PietteAffiliations: University Hospital Center Lille; 59037 Lille Cedex, France PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byEccema dishidrótico tras el tratamiento con inmunoglobulinas intravenosasEmerging Adverse Cutaneous Drug ReactionsPompholyx and eczematous reactions associated with intravenous immunoglobulin therapyIntravenous Immunoglobulin-Induced, Non-Eczematous, Vesiculobullous Eruptions in Stevens-Johnson SyndromeIntravenous immunoglobulins-induced eczematous eruption: A long-term follow-up studyBlood, blood components, plasma, and plasma products 15 December 1997Volume 127, Issue 12Page: 1130KeywordsLesionsMeningitisPathogenesisPruritusSkin reactionSweatSweat glandsUrticariaVasculitisVesicles ePublished: 15 August 2000 Issue Published: 15 December 1997 Copyright & PermissionsCopyright © 1997 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...