CORTICOTROPIN AND ADRENAL STEROIDS AS ADJUNCTS TO THE TREATMENT OF TUBERCULOUS MENINGITIS
Authors: J R JOHNSON, N E FURSTENBERG, R PATTERSON, H K SCHOCH, W N DAVEY
Journal: Annals of Internal Medicine (1957)

Article1 February 1957CORTICOTROPIN AND ADRENAL STEROIDS AS ADJUNCTS TO THE TREATMENT OF TUBERCULOUS MENINGITISJ. RICHARD JOHNSON, M.D., NANCY E. FURSTENBERG, M.D., ROY PATTERSON, M.D., HENRY K. SCHOCH, M.D., WINTHROP N. DAVEY, M.D.J. RICHARD JOHNSON, M.D.Search for more papers by this author, NANCY E. FURSTENBERG, M.D.Search for more papers by this author, ROY PATTERSON, M.D.Search for more papers by this author, HENRY K. SCHOCH, M.D.Search for more papers by this author, WINTHROP N. DAVEY, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-46-2-316 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptINTRODUCTIONThe proposition that corticotropin and the adrenal steroids are worthy and often vital adjuncts to the antimicrobial therapy of certain infections has been strongly defended by some1, 2 and just as strongly refuted by others.3, 4 In this regard, it must be accepted that these hormones (if used alone) do reduce the resistance of many species of hosts to a wide variety of infections.3 Experimental animal studies of combined hormonal and antimicrobial therapy, however, show little consistency as to results, even in the same species of animals.5When using such combinations of drugs in clinical situations, the proponents of...Bibliography1. Kinsell LW: The clinical application of pituitary adrenocorticotropic and adrenal steroid hormones, Ann. Int. Med. 35: 615, 1951. LinkGoogle Scholar2. Spink WW: Adrenocorticotropic hormone and adrenal steroids in the management of infectious diseases, Ann. Int. Med. 43: 685, 1955. LinkGoogle Scholar3. Thomas L: Cortisone, ACTH and infection, Bull. New York Acad. Med. 31: 485, 1955. MedlineGoogle Scholar4. Editorial: Cortisone, ACTH and infection, New England J. Med. 254: 41, 1956. CrossrefGoogle Scholar5. JohnsonDavey JRWN: Cortisone, corticotropin, and antimicrobial therapy in tuberculosis in animals and man: a review, Am. Rev. Tuberc. 70: 623, 1954. MedlineGoogle Scholar6. ShaneRiley SJC: Tuberculous meningitis: combined therapy with cortisone and antimicrobial agents, New England J. Med. 249: 829, 1953. CrossrefMedlineGoogle Scholar7. Bulkeley WC: Tuberculous meningitis treated with ACTH and isoniazid, Brit. M. J. 2: 1127, 1953. CrossrefMedlineGoogle Scholar8. Barnard C: Tuberculous meningitis: cortisone treatment as an adjunct to the antibiotics, South African M. J. 27: 219, 1953. MedlineGoogle Scholar9. AshbyGrant MH: Tuberculous meningitis treated with cortisone, Lancet 1: 2, 1955. Google Scholar10. KendigChoyJohnson ELSHWH: Observations on the effect of cortisone in the treatment of tuberculous meningitis. Report of two cases. Am. Rev. Tuberc. 73: 99, 1956. MedlineGoogle Scholar11. Johnson JR: Tuberculous meningitis; use of corticotropin as an adjunct to chemotherapy. Case report and review of literature, Am. Rev. Tuberc. 72: 825, 1955. MedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Ann Arbor, Michigan*Received for publication July 16, 1956.From the Medical Service, Veterans Administration Hospital, Ann Arbor, Michigan, and the Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan.Presented in part at the National Tuberculosis Association Fifty-second Annual Meeting, Medical Session, May 22, 1956, New York, N. Y.Requests for reprints should be addressed to J. Richard Johnson, M.D., Chief, Pulmonary Disease Section, Veterans Administration Hospital, Ann Arbor, Michigan. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byCorticosteroids and tuberculosis: risks and use as adjunct therapyEvaluation of Corticosteroids in Treatment of Tuberculous MeningitisDexamethasone in Tuberculous Meningitis Relationship of Cerebrospinal Fluid Effects to Therapeutic EfficacyRICHARD D. O'TOOLE, M.D., GEORGE F. THORNTON, M.D., MRINAL K. MUKHERJEE, D.P.H., R. L. NATH, PH.D.Corticotrofina e cortiomdes em neurologia: avaliação critica dos resultados em 518 pacientes hospitalizadosTHE ROLE OF ADRENOCORTICOTROPHIC AND ADRENOCORTICOSTEROID HORMONES IN THE TREATMENT OF TUBERCULOSISDie zusätzliche Prednisolon-Anwendung bei verschiedenen Tuberkulose-Verlaufsformen und während einer gleichzeitigen SchwangerschaftTHE PROBLEM OF OPTIC ATROPHY COMPLICATING TUBERCULOUS MENINGITIS*ROGER M. DES PREZ, M.D., CLARENCE W. JORDAHL, M.D.Die Corticosteroidtherapie bei der Tuberkulose und anderen LungenerkrankungenTuberculosisAdrenocortical steroid therapy and chemotherapy in acute, far-advanced toxic pulmonary tuberculosisACTH and Adrenocorticosteroids as Therapeutic Adjuncts in Infectious Diseases 1 February 1957Volume 46, Issue 2Page: 316-331KeywordsAdrenocorticotropic hormoneAntimicrobialsComaHormonal therapyHormonesHospital medicineMeningitisPneumoniaSteroidsTuberculosis ePublished: 1 December 2008 Issue Published: 1 February 1957 PDF downloadLoading ...