THE NATURE OF MYXEDEMA: ALTERATIONS IN THE SERUM ELECTROLYTE CONCENTRATIONS AND RADIOSODIUM SPACE AND IN THE EXCHANGEABLE SODIUM AND POTASSIUM CONTENTS
Authors: J K AIKAWA
Journal: Annals of Internal Medicine (1956)

Article1 January 1956THE NATURE OF MYXEDEMA: ALTERATIONS IN THE SERUM ELECTROLYTE CONCENTRATIONS AND RADIOSODIUM SPACE AND IN THE EXCHANGEABLE SODIUM AND POTASSIUM CONTENTSJERRY K. AIKAWA, M.D.JERRY K. AIKAWA, M.D.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-44-1-30 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptSince Ord in 18781 applied the name "myxedema" to the peculiar subcutaneous swelling characteristic of adult hypothyroidism, numerous studies have been directed toward the identification of the slimy colloid possessing the chemical characteristics of a mucoprotein which is responsible for this type of swelling. Byrom2 has previously used the external metabolic balance method to study the nature of the disturbance in fluid distribution which may be associated with this abnormal deposition of colloid.Recent improvements in flame photometry and the current availability of radioactive isotopes of sodium and potassium have made possible a more direct investigation of the disturbances in...Bibliography1. Ord WM: On myxedema, a term proposed to be applied to an essential condition in the "cretinoid" affection occasionally observed in middle-aged women, Med. Chir. Trans., London 61: 57, 1878. CrossrefMedlineGoogle Scholar2. Byrom FB: The nature of myxedema, Clin. Sc. 1: 273, 1933. Google Scholar3. CorsaOlneySteenburgBallMoore LJMRWMRFD: The measurement of exchangeable potassium in man by isotope dilution, J. Clin. Investigation 29: 1280, 1950. CrossrefMedlineGoogle Scholar4. MosherBoyleBirdJacobsonBatchelorIseriMyers REAJEJSDTMLJGB: The use of flame photometry for the quantitative determination of sodium and potassium in plasma and urine, Am. J. Clin. Path. 19: 461, 1949. CrossrefMedlineGoogle Scholar5. EdelmanJamesBrooksMoore ISAHLFD: Body sodium and potassium. IV. The normal total exchangeable sodium: its measurement and magnitude, Metabolism 3: 530, 1954. MedlineGoogle Scholar6. AikawaHarrellEisenberg JKGTB: The exchangeable potassium content of normal women, J. Clin. Investigation 31: 367, 1952. CrossrefMedlineGoogle Scholar7. GoldbergChaikoff RCIL: Myxedema in the radiothyroidectomized dog, Endocrinology 50: 115, 1952. CrossrefMedlineGoogle Scholar8. ManciniGarberide la Balze REJCFA: Mucoproteins of the connective tissue of the skin in generalized myxedema, J. Nat. Cancer Inst. 13: 247, 1952. MedlineGoogle Scholar9. Brewer DB: Myxedema: an autopsy report with histochemical observations on the nature of the mucoid infiltrations, J. Path. and Bact. 63: 503, 1951. CrossrefMedlineGoogle Scholar10. Margitay-Becht A: Der Natriumgehalt des Blutserums bei Myxödem, Klin. Wchnschr. 16: 1353, 1937. CrossrefGoogle Scholar11. GibsonHarris JGAW: Clinical studies of the blood volume. V. Hyperthyroidism and myxedema, J. Clin. Investigation 18: 59, 1939. CrossrefMedlineGoogle Scholar12. PickeringFisherScott DEDAKG: Growth and metabolism in normal and thyroid-ablated infant rhesus monkeys (Macaca mulatta), Am. J. Dis. Child. 86: 157, 1953. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Denver, Colorado*Received for publication July 25, 1955.From the Department of Medicine, University of Colorado School of Medicine, Denver.†This work was supported in part by a grant-in-aid from the American Heart Association and in part under a contract with the U. S. Atomic Energy Commission.‡Established Investigator of the American Heart Association.K42 and Na24 were supplied by the Oak Ridge National Laboratory, Oak Ridge, Tennessee, on allocation from the U. S. Atomic Energy Commission. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byPediatric Patient With Altered Mental Status and HypoxemiaWhole-Body Exchangeable Sodium in Cardiovascular and Endocrine DisordersHypothyroidismEffects of thyroid function on blood pressure. Recognition of hypothyroid hypertension.The Thyroid GlandPerfusion Technology in the Hypothyroid PatientREVERSIBLE HYPERTENSION AND HYPOTHYROIDISMNeuromuscular status in hypothyroidismNeurohypophyseal peptides in hypothyroid rats: Plasma levels and kidney responseDECLARATION OF ALMA-ATAALDOSTERONE IN MYXŒDEMAThe role of vasopressin in the impaired water excretion of myxedemaDie SchilddrüseRelation between Erythrocyte and Plasma Lithium Concentrations as an Index in Psychiatric DiseaseNonosmolar Factors Affecting Renal Water ExcretionThe thyroid and the kidneyDevelopmental Changes in Ionic Composition of the Brain in Hypo and HyperthyroidismThe Thyroid GlandMUSCULAR ABNORMALITIES OF HYPOTHYROIDISMImpaired water excretion in myxedemaEffects of myxedema on the renal diluting and concentrating mechanismSodium, potassium and water metabolism in myxoedemaÉtude Comparative Des Effets De L'Hyperthyrudisme Et De L'Hyperthyrudisme Sur Le Débit Et La Concentration Des Urines Du RatMyxedema crisis of pituitary or thyroid originThe ThyroidNeurologic Manifestations of MyxedemaStudies on the Mechanism of Hyponatremia and Impaired Water Excretion in MyxedemaMARTIN GOLDBERG, M.D., MARTIN REIVICH, M.D.FATAL MYXEDEMA, WITH AND WITHOUT COMA*†JOHN F. NICKERSON, S. RICHARDSON HILL JR., M.D., JEAN H. MCNEIL, M.D., SAMUEL B. BARKER, Ph.D.NEUROLOGIC COMPLICATIONS OF MYXEDEMA: CONVULSIONS*EDWIN C. EVANS, M.D., F.A.C.P.Total body exchangeable potassium and sodium and extracellular fluid in chronic pulmonary insufficiencyThe alkali metal ions in the organismHypothyroidismDas Herz bei Myxödem und HypothyreoseStörungen des Kaliumstoffwechsels und ihre klinische BedeutungPathophysiology of Rheumatic FeverPhysiology and treatment of myxedema 1 January 1956Volume 44, Issue 1Page: 30-39KeywordsAttentionEdemaHeartHypothyroidismInflammationPotassiumResearch laboratoriesSodiumThyroid ePublished: 1 December 2008 Issue Published: 1 January 1956 PDF downloadLoading ...