tbuckley/cabot-search huggingface dataset:
Tolerance in transgenic mice expressing class II major histocompatibility complex on pancreatic acinar cells.
Authors: D Lo, L C Burkly, R A Flavell, R D Palmiter, R L Brinster
Journal: The Journal of Experimental Medicine (1989)

To study the nature of tolerance to antigens not expressed by cells of the lymphoid system, expression of class II MHC I-E was targeted to the acinar cells of the exocrine pancreas in transgenic mice (elastase [EL]-I-E). Despite the absence of detectable I-E in the thymus of EL-I-E transgenic mice, both thymocytes and peripheral T lymphocytes were tolerant to I-E, and the pancreas was free of autoimmune infiltrates. Nontolerant T cells adoptively transferred into irradiated or T-depleted transgenic mice rapidly destroy the I-E+ components of the pancreas; however, adoptive transfer of nontolerant T lymphocytes into nonirradiated transgenic mice do not. These results suggest that tolerance in transgenic mice is maintained by some peripheral tolerance mechanism. However, further studies indicate that tolerance in transgenic mice is not maintained by specific Ts cells. For example, cell mixing experiments both in vitro and in vivo fail to reveal dominant unresponsiveness. Furthermore, nontolerant T cells injected into otherwise unmanipulated EL-I-E mice can be primed in situ (by injections of I-E+ spleen cells) to destroy the I-E+ acinar cells.
624 HEPATITIS C VIRUS INFECTION ALTERS SERUM LEVELS OF THE MAJOR TYPE III INTERFERON IL-29
Authors: B. Langhans, M. Michalk, I. Braunschweiger, G. Gornik, N. Vidovic, L. Leifeld, J. Oldenburg, T. Sauerbruch, U. Spengler
Journal: Journal of Hepatology (2008)
The Prospective Payment System: A Civic Good, Not a Civil War-Reply
Authors: K. L. Kahn, E. B. Keeler, R. H. Brook
Journal: JAMA (1991)

<h3>In Reply. —</h3> We believe that Dr Haruda has misunderstood some of our findings. In particular, he bases his conclusions about increased death rates following the implementation of the DRG-based prospective payment system (PPS) on data that were meant to show that sickness at admission increased following PPS. We calculated that the risk of expected (or predicted) deaths based on the patient's sickness at admission increased 1.6 percentage points from 28.5 before PPS to 30.1 after PPS was implemented.<sup>1</sup> After adjusting for this difference in sickness at admission, our data show, if anything, that mortality decreased in the time period after PPS was implemented relative to the baseline or before PPS time period.<sup>2</sup>We apologize if our writing has contributed to Dr Haruda's misunderstanding.
Large personalised medicine trial in lung cancer heralds new research partnership
Authors: I. Torjesen
Journal: BMJ (2014)

A large, ground breaking trial in which patients with non-small cell lung cancer will be given specific drugs according to the genetics of their tumour has been launched in the UK.

What makes this trial, called the National Lung Matrix trial, unique is that it is a collaboration between Cancer Research UK, the NHS and two drug companies—AstraZeneca and Pfizer. The trial will include drugs in development from both companies—12 from AstraZeneca and two from Pfizer—and patients will be enrolled into the trial arm offering the drug that best matches their genetic profile.

While other personalised or stratified medicine trials have been set up, these are mainly based at big cancer centres in the US. This UK trial will involve thousands of patients from across the UK. Biopsy …
FIVE-YEAR CLINICAL OUTCOME AFTER IMPLANTATION OF SIROLIMUS-ELUTING STENTS VERSUS PACLITAXEL-ELUTING STENTS IN UNSELECTED PATIENTS WITH CORONARY ARTERY DISEASE: KOMATE DES REGISTRY
Authors: Young-Guk Ko, Jung-Sun Kim, Donghoon Choi, Myeong-Ki Hong, Yangsoo Jnag, Pil Ki Min, Young Won Yoon, Bum-Kee Hong, Byoung Kwon Lee, Hyuck Moon Kwon
Journal: Journal of the American College of Cardiology (2010)
Knowledge Coupling: New Premises and New Tools for Medical Care and Education
Authors: Richard M. Stillman
Journal: JAMA (1992)

<i>Knowledge Coupling</i>is a comprehensive dissertation on the rationale for using computers in medicine. Dr Weed postulates that the complexity of the health sciences precludes accurate decision making and record keeping without the assistance of the computer. He then explores the methods by which computer assistance can be applied to clinical management, education, and research in medicine. Applications in dentistry and veterinary medicine are also mentioned. In each section, Dr Weed's incisive observations about the current status of our health care system preface his perception of how a computer-based system can surmount almost any problem. With regard to clinical management, he writes, "Many students find it difficult to separate diagnostic activities from those undertaken for immediate therapeutic action.... To say that in life-threatening situations we must first determine the cause before taking action is like saying that we must know why the child fell in the water before we
Successful Treatment of 750 Criminal Addicts
Authors: Vincent P. Dole
Journal: JAMA (1968)

A four year trial of methadone blockade treatment has shown 94% success in ending the criminal activity of former heroin addicts. The majority of these patients are now productively employed, living as responsible citizens, and supporting families. The results show unequivocally that criminal addicts can be rehabilitated by a well-supervised maintenance program.
Voice after laryngectomy.
Authors: J. S. Tobias
Journal: BMJ (1992)

the final choice of treatment.In a recent survey on upwards, by Gleeson's chosen classification of deserved a mention in Rubens and colleagues' the mnageent flarngea caner inthe nite stag) ca be ured2 Not only is this clearly brief discussion of the treatment of myeloma, in Kingdom and Ontario, Canada, Gaze etal afound contrary to his statement that "Others present with preference to trials of high dose chemotherapy that 84% of otolaryngologists and 96% of clinical advanced disease, and for these unlucky patients with bone marrow transplantation, which are at oncologists would recommend primary radio-total laryngectomy provides the only hope of long present too small or in which long term follow up is therapy for T3,N0,M0 laryngeal cancer.'~termsurvival" but analysis of "salvage" surgeryinsufficient to determine outcome.MultipleThe recent advances in stomal valves and speech that is, total laryngectomy after failure of non-myeloma is perhaps an example of a cancer for buttons are excellent news for patients in whom surgical treatment -has confirmed that avoiding which achieving an accurate consensus view of laryngectomy is inevitable, but we should still early surgery does not seem to prejudice overall optimal management from published reports strive to allow as many patients as possible to retain survival (H R Grant et al, 5th European conference required more detailed and wider consultation their larynges with good speech function.on clinical oncology, London, September 1989).than was undertaken.
Clinical and photobiological characteristics of xeroderma pigmentosum complementation group F: a review of cases from Japan
Authors: K. YAMAMURA, M. ICHIHASHI, T. HIRAMOTO, M. OGOSHI, K. NISHIOKA, Y. FUJIWARA
Journal: British Journal of Dermatology (1989)

Journal Article Clinical and photobiological characteristics of xeroderma pigmentosum complementation group F: a review of cases from Japan Get access K. YAMAMURA, K. YAMAMURA Department of Dermatology, Kobe University School of Medicine, Kobe, Japan Search for other works by this author on: Oxford Academic Google Scholar M. ICHIHASHI, M. ICHIHASHI Department of Dermatology, Kobe University School of Medicine, Kobe, Japan Dr M. Ichihashi, Department of Dermatology, Kobe University School of Medicine, Kusunoki‐cho 7‐5‐1, Chuo‐ku, Kobe 650, Japan. Search for other works by this author on: Oxford Academic Google Scholar T. HIRAMOTO, T. HIRAMOTO Department of Dermatology, Kobe University School of Medicine, Kobe, Japan Search for other works by this author on: Oxford Academic Google Scholar M. OGOSHI, M. OGOSHI Department of Dermatology, Kobe University School of Medicine, Kobe, Japan Search for other works by this author on: Oxford Academic Google Scholar K. NISHIOKA, K. NISHIOKA Department of Dermatology, Yamaguchi University School of Medicine, Ube, Japan Search for other works by this author on: Oxford Academic Google Scholar Y. FUJIWARA Y. FUJIWARA Department of Radiation Biophysics, Kobe University School of Medicine, Kobe, Japan Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 121, Issue 4, 1 October 1989, Pages 471–480, https://doi.org/10.1111/j.1365-2133.1989.tb15514.x Published: 01 October 1989
A Proposal for a Combined Family Practice—Internal Medicine Residency
Authors: Richard G. Christiansen
Journal: JAMA (1986)

Both family practice and internal medicine currently train graduates for primary care. A single, four-year program is proposed that combines the strengths of family practice and internal medicine, incorporates community needs into the curriculum, and addresses the physician's changed role in a revolutionized health care provision system. Specific training recommendations and the societal and professional advantages of such a program are detailed. (<i>JAMA</i>1986;255:2628-2630)
415 TELAPREVIR IN COMBINATION WITH PEGINTERFERON ALFA-2A AND RIBAVIRIN INCREASED SUSTAINED VIROLOGIC RESPONSE RATES IN TREATMENT-NAIVE PATIENTS REGARDLESS OF RACE OR ETHNICITY
Authors: G.M. Dusheiko, M.W. Fried, R. Reddy, D.R. Nelson, N. Bzowej, N. Adda, C.I. Wright, L. Bengtsson, S. George, S.L. Flamm
Journal: Journal of Hepatology (2011)
Hemochromatosis Resulting from Prolonged Oral Iron Therapy
Authors: Brian F. Johnson
Journal: New England Journal of Medicine (1968)

REPORTS1 2 3 4 5 6 of hemochromatosis apparently resulting from orally administered iron medication are exceptionally rare. The case reported below supports the theory that iron excess is the important causative factor in hemochromatosis.Case ReportA 70-year-old housewife was admitted to the hospital in November, 1965, with a history of progressive ill-health and weight loss for 9 months. A physician had previously noted hepatomegaly and diabetes mellitus controllable by diet. Recently, increasing breathlessness and swelling of the abdomen and ankles had appeared. The past history revealed that, in 1948, a physician had demonstrated a hemoglobin of 8.3 gm per 100 ml. Oral iron . . .
Low-Fat Diet in Intestinal Lymphangiectasia
Authors: Graham H. Jeffries, Antoine Chapman, Marvin H. Sleisenger
Journal: New England Journal of Medicine (1964)

HYPOPROTEINEMIA may result from excessive enteric leakage of plasma proteins in patients with abnormal intestinal lymphatic drainage.1 2 3 4 5 6 Although intestinal lymphatic obstruction has not been clearly demonstrated in these patients, dilated intestinal lymphatic vessels have been described in mucosalbiopsy specimens6 and have been observed at laparotomy in the serosa and mesentery.1 , 3 4 5 6 The lymphatic lesion may be either congenital, with onset of symptoms in infancy and associated peripheral lymphedema,2 , 4 , 6 7 8 or chylous ascites,6 7 8 9 or both, or may be acquired and become manifest for the first time in the adult.3 , 5 , 6 A similar dilatation of lymphatic vessels has been described in a patient with constrictive . . .
Mesoporous Silica Nanoparticle‐based H<sub>2</sub>O<sub>2</sub> Responsive Controlled‐Release System Used for Alzheimer's Disease Treatment
Authors: Jie Geng, Meng Li, Li Wu, Cuie Chen, Xiaogang Qu
Journal: Advanced Healthcare Materials (2012)

Abstract Metal ions play important roles in amyloid aggregation and neurotoxicity. Metal‐ion chelation therapy has been used in clinical trials for Alzheimer's disease (AD) treatment. However, clinical trial studies have shown that long‐term use of metal chelator can cause adverse side effect, subacute myelo‐optic neuropathy. Nanoparticle engineering processes have become promising approaches for efficiently drugs delivery. A series of modified mesoporous silica nanoparticles (MSNs) using redox, pH, competitive binding, light, and enzyme as actuators have been demonstrated. Recently, significant advances in sensing oxidative stress have been made by taking advantage of specific chemistry between cellular oxidants such as H 2 O 2 . Here we report a biocompatible delivery platform by using H 2 O 2 responsive controlled‐release system to realize target delivery of AD therapeutic metal chelator. The advantage of this novel strategy is that metal chelator can only be released by the increased levels of H 2 O 2 , thus, it would not interfere with the healthy metal homeostasis and can overcome strong side effect of metal chelator after long‐term use. By taking advantage of the good biocompatibility, cellular uptake properties, and efficient intracellular release of metal chelators, the delivery system is promising for future in vivo controlled‐release biomedical applications.
230. The Study on Chitosan Nanoparticles as New Gene Delivery System
Authors: Minli Sun, Hao Zhang, Baigen Zhang
Journal: Molecular Therapy (2005)

Top of pageAbstract
Object: To find a new gene delivery system with nanotechnology.

Methods: 1. The preparation of chitosan nanoparticles: The PLGA in methylene dichloride solution(0.04%) was dropped in the chitosan solution solved in acetic acid solution with high speed stirring. When turned opalescent, the solution centrifuge in a low speed. The supernatant were shifted into a clean centrifuge tube and centrifuged with high speed.The white precipitation were seen at bottom of the tube. The supernatant were discarded and the precipitation were washed twice with deoinized water and kept in PBS buffer in 4|[deg]|. A little drop in clean cover glass was dried in vacuum and analyzed with scan electron microscopy. 2. Chitosan coupled with plasmids:100|[mu]|g chitosan nanoparticles were mixed with 10|[mu]|g eNOS plamids, vortex for 20s, then placed in room temperature for reaction for 2 h. 3.Transfection into cells: the non serum culture medium was added into the mixture of chitosan nanoparticles and plasmids. When the human umbilicus vascular endothelial cell fuse to 70|[sim]|80%, the mixture were added, cultured in 37|[deg]|, 5%CO2 for 5 hours in culture tank with the cells transfected with the simple plasmids as control. The nonserum medium was discarded. After the cells were washed twice with cold PBS buffer, the medium with 10% serum was added. After 48 hours in 37|[deg]|, 5%CO2, the medium was changed with non serum medium overnight. Then the supernatant was kept and analyzed with Western-blot and total RNA was extracted with Trizol reagent from the cells as RT-PCR.

Results: In the pictures (enlarged 40,000|[times]|)of scan electron microscopy of, chitosan nanparticles appeared microsphere and the average size was 250nm. The cells transfected with the mixture growing in order and no obvious cell toxicity were seen. The electrophoresis picture of RT-PCR showed that target gene expression was much better in chitosan nanoparticles compared with simple gene transfected. Western-blot had similar result with RT-PCR.

Conclusion: The chitosan nanoparticles can be used as a new gene delivery system.
[202] SELECTIVE LONG-TERM ACTIVATION OF CANNABINOID CB RECEPTORS REDUCES HEPATIC FIBROSIS IN CIRRHOTIC RATS WITH ASCITES
Authors: J. Munyoz-Luque, J. Ros, G. Fernandez-Varo, S. Tugues, M. Morales-Ruiz, C.L. Alvarez, S.L. Friedman, W. Jimenez
Journal: Journal of Hepatology (2007)
TCT-326 In-Hospital and Long-Term Prognosis of Anemia on Admission in Patients Undergoing Percutaneous Coronary Intervention
Authors: Ester Canovas Rodriguez, Lorenzo Hernando Marrupe, Alfonso Freites Esteves, Pablo Salinas, Roberto Del Castillo Medina, Adriana De la Rosa Riestra, Javier Alonso Bello, Javier Botas Rodriguez
Journal: Journal of the American College of Cardiology (2013)
PAPAIN-INDUCED CHANGES IN RABBIT CARTILAGE
Authors: Theodore T. Tsaltas
Journal: The Journal of Experimental Medicine (1958)

Some biochemical aspects of the collapse of the rabbit ears produced by the intravenous injection of papain have been studied. A marked depletion of chondromucoprotein (M.C.S.) and a reduction of the S35 content of cartilage matrix were found to coincide with the gross and histologic changes in the cartilage. At the same time there was a marked increase in the amount of S35 in the serum and an increase of S35 and glucuronic acid excreted in the urine. Alteration in the composition of the M.C.S. remaining in the cartilage of the papain-injected animals was detected. The findings indicate that the collapse of the rabbit ears is due to loss of chondromucoprotein from cartilage and reduction of chondroitin sulfate in the chondromucoprotein that remains. All these changes were reversed in recovery.
Simvastatin Reduces <i>Chlamydophila pneumoniae</i> –Mediated Histone Modifications and Gene Expression in Cultured Human Endothelial Cells
Authors: Bernd Schmeck, Wiebke Beermann, Philippe Dje N’Guessan, Andreas C. Hocke, Bastian Opitz, Julia Eitel, Quoc Thai Dinh, Martin Witzenrath, Matthias Krüll, Norbert Suttorp, Stefan Hippenstiel
Journal: Circulation Research (2008)

Inflammatory activation of the endothelium by Chlamydophila pneumoniae infection has been implicated in the development of chronic vascular lesions and coronary heart disease by seroepidemiological and animal studies. We tested the hypothesis that C. pneumoniae induced inflammatory gene expression is regulated by Rho-GTPase-related histone modifications. C. pneumoniae infection induced the liberation of proinflammatory interleukin-6, interleukin-8, granulocyte colony-stimulating factor, macrophage inflammatory protein-1beta, granulocyte/macrophage colony-stimulating factor, and interferon-gamma by human endothelial cells. Cytokine secretion was reduced by simvastatin and the specific Rac1 inhibitor NSC23766 but was synergistically enhanced by inhibitors of histone deacetylases trichostatin A and suberoylanilide hydroxamic acid. Infection of endothelial cells with viable C. pneumoniae, but not exposure to heat-inactivated C. pneumoniae or infection with C. trachomatis, induced acetylation of histone H4 and phosphorylation and acetylation of histone H3. Pretreatment of C. pneumoniae-infected cells with simvastatin or NSC23766 reduced global histone modifications as well as specific modifications at the il8 gene promoter, as shown by chromatin immunoprecipitation. Reduced recruitment of nuclear factor kappaB p65/RelA as well as of RNA polymerase II was observed in statin-treated cells. Taken together, Rac1-mediated histone modifications seem to play an important role in C. pneumoniae-induced cytokine production by human endothelial cells.
Treatment of liposclerosis of the leg by fibrinolytic enhancement: a preliminary report.
Authors: N L Browse, P E Jarrett, M Morland, K Burnand
Journal: BMJ (1977)

Fourteen patients with longstanding lipodermatosclerosis of their lower legs, secondary to venous disease in 11, were treated for three months with stanozolol, a drug that enhances fibrinolytic activity. No other treatment was given and no change made in existing treatment. All the patients improved. Two were cured in three months, three were able to stop treatment in the next three to 11 months, and the other nine continued to improve. Fibrinolytic enhancement, with stanozolol, seems to be a worthwhile addition to the treatment of venous liposclerosis and deserves further study.
Myocardial Perfusion Imaging With Pharmacologic Stress in a 9-Year-Old Girl
Authors: BRIAN K. McCANDLESS, JEFFREY A. COOPER
Journal: Clinical Nuclear Medicine (1994)

A 9-year-old girl with Hutchinson-Gilford syndrome (progeria) was admitted with syncope. She had a cerebral infarction 8 months earlier. ECG showed ST segment depression in the lateral precordial leads. Because of the high prevalence of premature atherosclerosis in patients with progeria, she was referred for myocardial perfusion imaging using dipyridamole. The patient was given 0.56 mg/kg dipyridamole intravenously over 4 minutes followed 4 minutes later by 1 mCi TI-201 chloride. Subsequent to the dipyridamole infusion, the patient was free of symptoms. The ST segment depression in the lateral leads became more pronounced, but was nondiagnostic due to the baseline abnormalities
Graft-versus-Host Disease — From the Bench to the Bedside?
Authors: Gerard Socié, Bruce R. Blazar
Journal: New England Journal of Medicine (2005)

During the past decade, progress in basic immunology has been impressive. In parallel, whereas our understanding of the pathophysiology of acute graft-versus-host disease (GVHD) has greatly improved, so has our knowledge of the complexities of the immune system. Much of the immunobiology of acute GVHD has been gleaned from preclinical models and far less from correlations with clinical observations or therapeutic interventions. In this review, we summarize some of the major advances in GVHD pathophysiology, including the translation of these from the bench to the bedside, and discuss preclinical approaches that warrant further exploration in the clinic.
Myocardial risk area defined by technetium-99m sestamibi imaging during percutaneous transluminal coronary angioplasty: Comparison with coronary angiography
Authors: Howard L. Haronian, Michael S. Remetz, Albert J. Sinusas, Jack M. Baron, Hylton I. Miller, Michael W. Cleman, Barry L. Zaret, Frans J.Th. Wackers
Journal: Journal of the American College of Cardiology (1993)
ABC of oxygen: Oxygen therapy in chronic lung disease
Authors: P J Rees, F Dudley
Journal: BMJ (1998)

### Oxygen in first aid

Oxygen can be used in acute situations where there is hypoxia because of acute lung injury or reduced ventilation, when there is underlying chronic lung disease, or when it is important to maintain oxygen delivery to certain tissues. Maintaining oxygen delivery may help tissue survival when there is cardiac failure with pulmonary oedema, ischaemic tissue (such as after an infarction), or a cerebrovascular accident. Oxygen saturation should be monitored by pulse oximetry. If oxygen saturation is low additional inspired oxygen should be used to maintain saturation near 100%.



Paramedics giving oxygen after a skiing accident



Oxygen can be used empirically in acute situations if a patient is cyanosed or has a raised respiratory rate. Generally it is safe to use a high inspired oxygen concentration as long as there is no suggestion that the patient has chronic obstructive pulmonary disease. The main danger of acute oxygen is that carbon dioxide retention may occur in some patients with chronic obstructive pulmonary disease. If this is suspected the oxygen should be given by a high flow 24% or 28% mask until arterial blood gases can be measured. Oxygen increases the fire hazard at the scene of an accident.



Small oxygen cylinders



In emergency situations lack of availability of oxygen and an appropriate delivery system may prevent early treatment. Ambulances carry oxygen and paramedical staff are trained to use the equipment in acute situations. Some general practitioners also carry small cylinders that can deliver 2 l/min for two hours, which avoids the need to wait for an ambulance.

### Occasional oxygen in chronic lung disease

Breathlessness in chronic lung conditions or in carcinoma of the bronchus may be intermittent. It is likely to increase on exertion, and simple everyday tasks such as washing, dressing, or eating may cause problems. Some patients feel that a short period on oxygen before or …