Lymphocyte Subsets in Severe Atherosclerosis before Revascularization
Authors: Georges Clerc
Journal: Annals of Internal Medicine (1997)

Letters15 June 1997Lymphocyte Subsets in Severe Atherosclerosis before RevascularizationGeorges Clerc, MD and Pierre Michel Roux, MDGeorges Clerc, MDHospital N.D. Bon-Secours, Metz, France and Pierre Michel Roux, MDHospital N.D. Bon-Secours, Metz, FranceAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-126-12-199706150-00028 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:Human atherosclerotic lesions contain macrophages and CD4+ T cells [1]. The antibody response to modified lipids found in atherosclerosis seems to be characteristic of the disease. The challenge is to elucidate how the immune system influences atherogenesis in relation to classic risk factors for atherosclerosis [2].We compared lymphocyte subsets of patients with severe atherosclerosis (17 with coronary artery disease and 11 with peripheral vascular disease) before bypass surgery with subsets in a control group (15 patients without atherosclerosis or with nonsignificant atherosclerosis in whom valvular disease was investigated by coronary angiography and vascular ultrasonography). The two ...References1. Stemme S, Hansson GK. Immune mechanisms in atherogenesis. Ann Intern Med. 1994; 26:141-6. Google Scholar2. Clerc G. Atherosclerosis as an immune disease. Medical Hypotheses. 1991; 36:24-6. Google Scholar3. Trinchiery G. Biology of natural killer cells. Adv Immunol. 1989; 47:187-376. Google Scholar4. Kobashigawa JA, Katznelson S, Laks H, Johnson JA, Yeatman L, Wang XM, et al. Effect of pravastatin on outcomes after cardiac transplantation. N Engl J Med. 1995; 333:621-7. Google Scholar Author, Article, and Disclosure InformationAffiliations: Hospital N.D. Bon-Secours, Metz, France PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByWeighted gene co-expression network analysis identifies specific modules and hub genes related to coronary artery diseaseBioinformatics analysis reveals the landscape of immune cell infiltration and immune-related pathways participating in the progression of carotid atherosclerotic plaquesBioinformatics analysis of vascular RNA-seq data revealed hub genes and pathways in a novel Tibetan minipig atherosclerosis model induced by a high fat/cholesterol dietTrained Immunity: Linking Obesity and Cardiovascular Disease across the Life-Course?Innate and adaptive immunity in atherosclerosisRevisiting the Functional Impact of NK CellsKiller cells in atherosclerosisCytotoxic lymphocytes and atherosclerosis: significance, mechanisms and therapeutic challengesThe regulation of immune cells by Lactobacilli: a potential therapeutic target for anti-atherosclerosis therapyPeripheral Blood Lymphocyte Subsets (CD4+, CD8+ T Cells, NK Cells) in Patients with Cardiovascular and Neurological Complications after Carotid EndarterectomyNatural killer cells in the innate immunity network of atherosclerosisUpregulation of Fractalkine and Its Receptor, CX3CR1, is Associated With Coronary Plaque Rupture in Patients With Unstable Angina PectorisAspects immunologiques de l'athéromeThematic review series: The Immune System and Atherogenesis. The unusual suspects:an overview ofthe minor leukocyte populations in atherosclerosisGenetics and molecular biologyGenetics and molecular biology 15 June 1997Volume 126, Issue 12Page: 1004-1005KeywordsAtherosclerosisAutoimmune diseasesLymphocytesNatural killer cellsPeripheral vascular diseaseStable coronary artery diseaseT cellsValvular diseasesVascular diseasesVascular surgery Issue Published: 15 June 1997 CopyrightCopyright © 1997 by American College of Physicians. All Rights Reserved.PDF DownloadLoading ...