tbuckley/cabot-search huggingface dataset:
ELECTROCARDIOGRAPHIC RECORD OF A DYING HEART
Authors: Solomon Krell
Journal: Annals of Internal Medicine (1944)

Case Reports1 November 1944ELECTROCARDIOGRAPHIC RECORD OF A DYING HEARTSOLOMON KRELL, M.D.SOLOMON KRELL, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-21-5-903 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptCASE REPORTMrs. E. R., a 74 year old female, was admitted to the Hospital and Home of the Daughters of Jacob on November 21, 1940, for custodial care. The diagnosis on admission was general arteriosclerosis, coronary sclerosis, and bilateral cataracts. Her chief complaints were those of general weakness, and occasional fainting spells. Examination of the heart revealed poor heart sounds, a regular rhythm, and a bloodpressure of 180 mm. Hg systolic and 70 mm. diastolic. An electrocardiogram taken on December 2, 1940, revealed a 2:1 A-V block, slurring and notching of the QRS complexes, a depressed ST2, inverted...Bibliography1. ROHMER : München med. Wchnschr., 1911, lviii, 2358. (Reference of KAHN and GOLDSTEIN.3) Google Scholar2. SCHELLONG F: Electrocardiography of heart in death, Klin. Wchnschr., 1923, ii, 1394-1399. CrossrefGoogle Scholar3. KAHNGOLDSTEIN MHI: The human dying heart, Am. Jr. Med. Sci., 1924, clxviii, 388. CrossrefGoogle Scholar4. WILLIUS FA: Clinical electrocardiograms, their interpretation and significance, 1929, W. B. Saunders, Philadelphia. CrossrefGoogle Scholar5. JEZERMASTERSCHWARTZ AAMSP: Observations on the mechanism of the dying heart in patients with Adams Stokes syndrome due to standstill of the ventricles, Am. Heart Jr., 1936, ii, 303. CrossrefGoogle Scholar6. FORMIGNE P: Apnea and convulsions following standstill of the heart, Am. Heart Jr., 1938, xiii, 129. CrossrefGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Bronx, New York*Received for publication January 21, 1943.From the Hospital and Home of the Daughters of Jacob, New York, N. Y. From the service of Dr. A. A. Brill and Dr. A. S. Hyman. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byElectrocardiogram in ventricular rupture after myocardial infarctionTHE MECHANISM OF SUDDEN DEATH IN DISSECTING ANEURYSM WITH INTRACARDIAC RUPTUREIntraventricular pressure and electrocardiographic recordings of the dying rabbit heartThe terminal electrocardiogram: Twenty-three case reports and a review of the literature 1 November 1944Volume 21, Issue 5Page: 903-907KeywordsBloodCataractsElectrocardiographyElectrode recordingEpinephrineHeartStable coronary artery diseaseSyncope ePublished: 1 December 2008 Issue Published: 1 November 1944 PDF downloadLoading ...
Handbook of Multiple Sclerosis
Authors: Stuart D. Cook
Journal: Annals of Internal Medicine (1991)

EtiopathogenesisThe History of Multiple SclerosisW. I. McDonaldThe Epidemiology of Multiple SclerosisWilliam Pryse-Phillips and Fiona CostelloThe Genetics of Multiple SclerosisJan Hillert and Thomas MastermanExperimental Models of Virus-Induced DemyelinationMauro C. Dal CantoEvidence for a Viral Etiology of Multiple SclerosisStuart D. CookExperimental Models of Autoimmune DemyelinationFred D. LublinEvidence for ImmunopathogenesisUte TraugottAutoantibodies in Demyelinating DiseaseAnne H. Cross, Jeri-Anne Lyons, and John L. TrotterClinical Pathologic FeaturesClinical FeaturesAaron E. MillerCognitive Impairment in Multiple SclerosisJill S. FischerLoss and Restoration of Impulse Conduction in Disorders of MyelinStephen G. WaxmanPathology of Multiple SclerosisJohn W. PrineasAxonal Injury in Multiple SclerosisCarl Bjartmar and Bruce D. TrappCerebrospinal FluidJohn N. Whitaker, Khurram Bashir, and Etty N. BenvenisteLaboratory Tests: Evoked PotentialsMarc R. NuwerNeuroimaging and the Use of Magnetic Resonance in Multiple SclerosisLael A. Stone, Nancy Richert, and Henry McFarlandTherapeutic ConsiderationsThe Natural History of Multiple SclerosisSandra Vukusic and Christian ConfavreuxPrognostic Factors in Multiple SclerosisOrhun H. Kantarci and Brian G. WeinshenkerTherapeutic Considerations: Rating ScalesRichard Rudick, Brian Weinshenker, and Gary CutterTherapeutic Considerations: Treatment of the Acute ExacerbationRaymond TroianoInterferon- -1b: Prophylactic Therapy in Multiple SclerosisKenneth P. Johnson and Peter A. CalabresiTherapeutic Considerations: Prophylactic Therapy with Interferon- -1aLawrence JacobsProphylactic Therapy-Glatiramer Acetate (Copaxone )Hillel PanitchTreatment of Multiple Sclerosis with Intravenous ImmunoglobulinP. RudgeImmunosuppressive DrugsMariko Kita and Donald E. GoodkinTreatment of Multiple Sclerosis: Bone Marrow Reconstitution, Total Lymphoid Irradiation, and Plasma ExchangeGeorge P. A. RiceSymptomatic TherapyRandall T. SchapiroSymptomatic Treatment and Rehabilitation in Multiple SclerosisCharles R. Smith and Labe ScheinbergExperimental Therapies with T-Cell Vaccines, Oral Myelin, and Monoclonal Antibodies in Multiple SclerosisSuprabha Bhat and Jerry S. WolinskyFuture ImmunotherapiesChristine Rohowsky-Kochan
Prostaglandins and Reproduction.
Authors: S El-mahgoub
Journal: Annals of Internal Medicine (1977)

This is a review of the literature and a summary of the findings and the clinical studies dealing with the role of PGs (prostaglandins) in the general field of reproduction. The chemical structure of PGs, including the biosynthetic chain, is reviewed briefly. The role PGs play in normal menstruation and dysmenorrheic menstruation, normal pregnancy, labor induction, postconception fertility control, and induced abortion are reviewed, citing the studies involved. Most of the PGs inhibit spontaneous motility of the human myometrium, varying according to the phase of the menstrual cycle. PGs also have an effect on the fallopian tubes, the ovary, and male reproductive organs. PGs, especially PGF, have been identified in human amniotic fluid during spontaneous abortion and labor. In the future, PGs may be used as postconception fertility control agents, even self-administered agents. PGs could influence the process of reproduction by: 1) delaying ovum transport; 2) having an effect on the site of implantation; 3) acting as an abortifacient; and 4) through luteolytic action.
Investigation on a novel and specific leukotriene B<sub>4</sub>receptor antagonist in the treatment of stable plaque psoriasis
Authors: None Van Pelt, None DE Jong, None Seijger, None Van Hooijdonk, None DE Bakker, None Van Vlijmen, None Parker, None Van Erp, None Van DE Kerkhof
Journal: British Journal of Dermatology (1998)

The aim of the present study was to investigate the efficacy and clinical tolerability of the specific leukotriene B4 receptor antagonist VML295 in the treatment of stable plaque psoriasis. Immunohistochemical and flow cytometrical methods were used to assess the effects on inflammation and epidermal proliferation. VML295 in the treatment of chronic plaque psoriasis was shown to be safe and well tolerated. After treatment, there was a statistically significant difference between patients treated with VML295 and patients treated with placebo with respect to the leukotriene B4-induced CD11b up-regulation on the cell surface of polymorphonuclear leukocytes derived from peripheral blood. Ex vivo CD11b up-regulation in the VML295-treated group was completely inhibited after 7 days of treatment (P = 0.001). This effect persisted until the end of the treatment period (P = 0.004 on day 15 and P < 0.0001 after 4 weeks), whereas CD11b up-regulation in the placebo group remained unaffected. There was no statistically significant difference in the median psoriasis area and severity index between the treatment groups at the end of the treatment period. During treatment, no significant histological changes were observed in the markers for cutaneous inflammation and epidermal proliferation. Although not statistically significant, a tendency for the increased expression of some markers of cutaneous inflammation and epidermal proliferation was observed after 1 week of treatment with VML295, and a decreased expression of these markers was seen after 4 weeks of treatment with VML295. This observation could indicate anti-inflammatory effects of VML295 appearing between 2 and 4 weeks after the start of treatment.
Allergic diseases, gene–environment interactions
Authors: H. Renz, M. Conrad, S. Brand, R. Teich, H. Garn, P. I. Pfefferle
Journal: Allergy (2011)

To cite this article: Renz H, Conrad M, Brand S, Teich R, Garn H, Pfefferle PI. Allergic diseases, gene–environment interactions. Allergy 2011; 66 (Suppl. 95): 10–12. Abstract Allergic asthma develops in part from dysregulation of the innate and adaptive immune functions, particularly an imbalance in the Th2‐driven adaptive immune response. This dysregulation is the result of complex interactions between genes and environment. These interactions occur both pre‐ and postnatally, providing opportunities for early interventions in immunological programming.
Abstract P012: Hypertension and Alterations in Left Ventricular Geometry in African Americans: The Jackson Heart Study
Authors: Marwah Abdalla, John N Booth, Keith M Diaz, Mario Sims, Paul Muntner, Daichi Shimbo
Journal: Circulation (2015)

Introduction: Compared with whites, African Americans (AAs) have a higher risk for hypertension-related cardiovascular disease outcomes, which may be related to alterations in left ventricular geometry. Scarce data exist on how the left ventricle remodels in response to hypertension among AAs. Hypothesis: We hypothesized that among AAs, hypertension will be associated with abnormal echocardiographic–derived left ventricular geometric patterns defined as concentric remodeling (CR), concentric hypertrophy (CH), and eccentric hypertrophy (EH). Methods: We analyzed data from the Jackson Heart Study, a community-based AA cohort who completed a baseline exam that included clinic blood pressure (CBP) and 2D echocardiography (n=5,301). CR, CH, EH, and normal patterns were defined according to left ventricular mass index and relative wall thickness defined using standard American Society of Echocardiography recommendations. The analysis was restricted to 4,572 participants with complete CBP, information on antihypertensive medication, and echocardiographic data. Results: Mean ± SD age was 55.5 ± 12.7 years; 64% were female. Mean ± SD systolic and diastolic CBP was 127 ± 18 and 79 ± 11 mmHg, respectively; 2,785 (61%) of participants had hypertension (CBP ≥140/90 mmHg and/or taking antihypertensive medications). The prevalence of CR, CH, and EH were 10.1%, 5.2%, and 8.2%, respectively. In a multivariable-adjusted model with a normal pattern as the referent group, hypertension was associated with a greater risk of CR, CH, and EH: odds ratio 1.85 (95% confidence interval (CI) 1.43-2.38), 4.16 (95% CI 2.53-6.86), and 1.67 (95% CI: 1.26-2.23) respectively. Among hypertensive participants, older age was significantly associated with CR, CH, and EH after multivariable adjustment. Higher systolic CBP, current smoking and a higher number of classes of antihypertensive medications were additionally significantly associated with CH and EH. Male sex, and heavy and moderate alcohol consumption versus none were also significantly associated with CR. Conclusions: In conclusion, abnormal left ventricular geometry was present in almost 25% of AAs. Hypertension was associated with each abnormal geometric pattern, with approximately a four-fold greater odds for CH. Future studies should examine whether abnormal left ventricular geometric patterns, particularly CH, explains the increased risk of cardiovascular disease outcomes associated with hypertension in AAs.
TCT-270 Comparison Among Drug-eluting Balloon, Drug-eluting Stent, and Plain Balloon Angioplasty for Treatment of In-Stent Restenosis: A Network Meta-analysis of 11 Randomized Controlled Trials
Authors: Joo Myung Lee, Jonghanne Park, Ki-Hyun Jeon, Ji-hyun Jung, Sang Eun Lee, Jung-Kyu Han, Hack-Lyoung Kim, Han-Mo Yang, Kyung Woo Park, Hyun-Jae Kang, Bon-Kwon Koo, Hyo-Soo Kim, Byung-Hee Oh, Young-Bae Park
Journal: Journal of the American College of Cardiology (2014)
Reply to Francesco Montorsi and Giorgio Gandaglia's Letter to the Editor re: Riccardo Autorino, Homayoun Zagar, Mirandolino B. Mariano, et al. Perioperative Outcomes of Robotic and Laparoscopic Simple Prostatectomy: A European–American Multi-institutional Analysis. Eur Urol 2015;68:86–94; Re: Matthew Bultitude, Ben Challacombe. Simple Prostatectomy: A Step Too Far for Laparoscopy? Eur Urol 2015;68:95–6. Eur Urol 2015;68:e7–8
Authors: Riccardo Autorino, Homayoun Zargar, Francesco Porpiglia
Journal: European Urology (2015)
Investigation of the male pattern baldness major genetic susceptibility loci AR/EDA2R and 20p11 in female pattern hair loss
Authors: S. Redler, F.F. Brockschmidt, R. Tazi-Ahnini, D. Drichel, M.P. Birch, K. Dobson, K.A. Giehl, S. Herms, M. Refke, N. Kluck, R. Kruse, G. Lutz, H. Wolff, M. Böhm, T. Becker, M.M. Nöthen, A.G. Messenger, R.C. Betz
Journal: British Journal of Dermatology (2012)

Background The aetiology of female pattern hair loss (FPHL) is largely unknown. However, it is hypothesized that FPHL and male pattern baldness (AGA) share common susceptibility alleles. The two major susceptibility loci for AGA are the androgen receptor (AR)/ectodysplasin A2 receptor (EDA2R) locus on the X‐chromosome, and a locus on chromosome 20p11, for which no candidate gene has yet been identified. Objectives To examine the role of the AR/EDA2R and 20p11 loci in the development of FPHL using 145 U.K. and 85 German patients with FPHL, 179 U.K. supercontrols and 150 German blood donors. Methods Patients and controls were genotyped for 25 single nucleotide polymorphisms (SNPs) at the AR/EDA2R locus and five SNPs at the 20p11 locus. Results Analysis of the AR/EDA2R locus revealed no significant association in the German sample. However, a nominally significant association for a single SNP (rs1397631) was found in the U.K. sample. Subgroup analysis of the U.K. patients revealed significant association for seven markers in patients with an early onset (P =0·047 after adjustment for the testing of multiple SNPs by Monte Carlo simulation). No significant association was obtained for the five 20p11 variants, either in the overall samples or in the analysis of subgroups. Conclusions The observed association suggests that the AR/EDA2R locus confers susceptibility to early‐onset FHPL. Our results do not implicate the 20p11 locus in the aetiology of FPHL.
Molecular and immunological characterization of novel weed pollen pan-allergens
Authors: N. Wopfner, P. Gruber, M. Wallner, P. Briza, C. Ebner, A. Mari, K. Richter, L. Vogel, F. Ferreira
Journal: Allergy (2008)

Background: Pan‐allergens like profilins, calcium‐binding proteins (CBPs), and nonspecific lipid transfer proteins have been suggested as possible specific markers for multiple pollen sensitizations, and could be used to predict cross‐sensitization/poly‐sensitization to several pollen allergens. Therefore, the purification and characterization of cross‐reacting allergens in pollen is an extremely important task towards correct allergy diagnosis. Methods: New pan‐allergens were identified by screening a ragweed pollen cDNA library with sera of patients allergic to mugwort pollen. Resulting proteins were cloned, expressed, purified and characterized. Results: We report complete cDNA sequences of two profilin isoforms (Amb a 8.01 and Amb a 8.02), two isoforms of a 2EF‐hand CBP (Amb a 9.01 and Amb a 9.02), a new 3EF‐hand CBP (Amb a 10) from ragweed pollen and a 2EF‐hand CBP from mugwort (Art v 5). All these proteins were expressed in Escherichia coli , purified to homogeneity and characterized by biochemical and immunological means. Conclusions: The identified proteins are novel pan‐allergens and can be used as diagnostic markers for polysensitization and used in component‐resolved diagnosis.
Clinical efficacy of different doses of rituximab in the treatment of pemphigus: a retrospective study of 27 patients
Authors: J.H. Kim, Y.H. Kim, M.R. Kim, S.-C. Kim
Journal: British Journal of Dermatology (2011)

Background The treatment of pemphigus is still challenging and some patients with pemphigus are unresponsive to conventional immunosuppressive treatments. Rituximab, a chimeric monoclonal anti‐CD20 antibody, binds to the CD20 antigen on the surface of B cells and has been reported to be effective for the treatment of recalcitrant pemphigus. Objective To compare the efficacy of different doses of rituximab in patients with pemphigus who were unresponsive to conventional therapies. Methods Twenty‐seven patients with pemphigus who received different doses of rituximab (375 mg m−2 per infusion weekly) were analysed retrospectively. We divided the patients into two groups: group 1 (n =12) received two infusions of rituximab and group 2 (n =15) received three or more infusions of rituximab at 1‐week intervals. The number of infusions was determined by the choice of each patient. The endpoints of the study were time to disease control, partial remission (PR) and complete remission (CR). Results There was no significant difference in time to achieve PR between the two groups (147 vs. 135 days, P =0·65). However, group 2 demonstrated better outcomes than group 1 in time to CR (443 vs. 149 days, P =0·06) and relapse rate (0% vs. 67%, P <0·01). Conclusions We conclude that three or more infusions of rituximab are more effective than two infusions for the treatment of pemphigus.
Analysis of<i>c</i>-<i>kit</i>exon 11 and exon 17 of urticaria pigmentosa that occurred in monozygotic twin sisters
Authors: None Sato-Matsumura, None Matsumura, None Koizumi, None Sato, None Nagashima, None Ohkawara
Journal: British Journal of Dermatology (1999)

Genomic DNA extracted from peripheral blood mononuclear cells of monozygotic twin patients with urticaria pigmentosa was investigated for mutations of proto-oncogene c-kit. Neither the patients nor their families had genomic mutations in exon 11 or exon 17 of c-kit. The patients did not have any systemic involvement or bone marrow abnormalities. There are indications that some genetic factors may participate in the pathogenesis of urticaria pigmentosa in monozygotic twins. In the present patients, factors other than genomic faults in exon 11 and exon 17 of c-kit may be responsible for the pathogenesis.
Spontaneous Echo Contrast and Atrial Fibrillation
Authors: H.-W. M. Breuer
Journal: Circulation (1999)

We read with great interest the article by McNamara et al 1 on intravenous immunoglobulin (IgG) therapy for myocarditis and acute dilated cardiomyopathy (DCM).There is as yet no general agreement of effective treatment of myocarditis and acute DCM.These workers are to be congratulated for conducting a welldesigned clinical study of adult patients with NYHA class III to IV heart failure, based on previously published clinical 2 and experimental 3 experience.We would like to stress 3 points that we consider crucial in our understanding of the significance of this treatment.The first is related to the presence of preceding or associated infectious manifestations (ie, fever, pleurodynia, myalgia, and upper respiratory tract symptoms).This strongly suggests that myocarditis is of viral or infectious origin.Accordingly, as shown in our previous study, 3 intravenous polyclonal IgG used in the study by McNamara et al 1 could have neutralizing antibody activities against causative agents.In this case, the effects of IgG may be drastic and super, as shown in the early study in our article. 3 The second point deals with the potential histological improvement by this treatment, even in the later stage, as shown in our study. 3 We consider that the marked and super improvement of left ventricular ejection fraction seen in all the patients in the study 1 may correlate with and depend on histological improvement.Some additional pathological data (ie, serial endomyocardial biopsy) could serve to make readers more clearly understand this point.Finally, although the precise mechanisms responsible for the efficacy of this treatment are still unknown, 4,5 IgG therapy is considered to have immunomodulatory and anti-inflammatory effects, as shown in our study. 3 The former includes antiidiotype, anti-autoantibody properties, and reticuloendothelial system blockade; the latter, downregulation of inflammatory cytokines, a sump for activated complement, and antisuperantigen antibodies.Thus, we keenly agree with the proposal that a more widespread randomized, placebo-controlled clinical trial in a larger population of patients with myocarditis and acute as well as chronic (ongoing) DCM 6 is warranted.
A general approach to single-nucleotide polymorphism discovery
Authors: Gabor T. Marth, Ian Korf, Mark D. Yandell, Raymond T. Yeh, Zhijie Gu, Hamideh Zakeri, Nathan O. Stitziel, LaDeana Hillier, Pui-Yan Kwok, Warren R. Gish
Journal: Nature Genetics (1999)
Exposure to grass pollen – but not birch pollen – affects lung function in Swedish children
Authors: O. Gruzieva, G. Pershagen, M. Wickman, E. Melén, J. Hallberg, T. Bellander, M. Lõhmus
Journal: Allergy (2015)

Abstract Allergic response to pollen is increasing worldwide, leading to high medical and social costs. However, the effect of pollen exposure on lung function has rarely been investigated. Over 1800 children in the Swedish birth cohort BAMSE were lung‐function‐ and IgE‐tested at the age of 8 and 16 years old. Daily concentrations for 9 pollen types together with measurements for ozone, NO 2 , PM 10 , PM 2.5 were estimated for the index day as well as up to 6 days before the testing. Exposure to grass pollen during the preceding day was associated with a reduced forced expiratory volume in 8‐yr‐olds; −32.4 ml; 95% CI : −50.6 to −14.2, for an increase in three pollen counts/m³. Associations appeared stronger in children sensitized to pollen allergens. As the grass species flower late in the pollen season, the allergy care routines might be weakened during this period. Therefore, allergy information may need to be updated to increase awareness among grass pollen‐sensitized individuals.