tbuckley/cabot-search huggingface dataset:
Extracorporeal Membrane Oxygenation for ARDS Due to 2009 Influenza A(H1N1)
Authors: Ross Freebairn
Journal: JAMA (2010)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Unusual complications in the Churg-Strauss syndrome
Authors: C Alvarez
Journal: Annals of the Rheumatic Diseases (2002)

Although abdominal complications are occasionally reported in the Churg-Strauss syndrome (CSS), bowel perforations, cholecystitis, eosinophilic peritonitis, and oophoritis are very unusual1–8 and normally resolve after immunosuppressive treatment. We report the case of a patient with CSS with these complications, which was fatal despite proper treatment.

A 64 year old woman with a 13 year history of urticaria, recurrent rhinitis, and asthma was admitted for abdominal pain. An increasing peripheral eosinophilia rising from 1% to 22% in the past five years was detected. Two years before hospital admission an extensive urticariform erythema developed. An abdominal ultrasonography performed during an asthmatic exacerbation when she had no abdominal pain disclosed a thick-walled gall bladder with no echogenic contents. An excised nasal polyp showed polypoid hyperplasia with many eosinophils.

Two and six weeks later she was readmitted owing to right upper quadrant pain. The leucocyte count was 1×1010/l with 34% eosinophils. Abdominal ultrasonography and computed tomography (CT) …
Mechanisms and potential therapeutic targets in allergic inflammation: recent insights
Authors: S. von Gunten, F. Cortinas-Elizondo, M. Kollarik, C. Beisswenger, P. M. Lepper
Journal: Allergy (2013)

Deeper insight into pathogenetic pathways and into the biological effects of immunomodulatory agents will help to optimize or adopt therapeutic strategies for atopic disorders. In this article, we highlight selected findings of potential therapeutic relevance that emerged from recent mechanistic studies with focus on molecular and cellular aspects of allergic inflammation. Furthermore, the often complex mechanisms of action of pleiotropic immunomodulatory agents, such as glucocorticoids, vitamin D, or intravenous immunoglobulin (IVIG), are discussed, as their dissection might reveal targets for novel therapeutics or lead to a more rational use of these compounds. Besides reporting novel evidence, this article points to areas of current debate or uncertainty and aims at stimulating scientific discussion and experimental work.
Optimum Calcium Requirement
Authors: I. Harris, J. T. Ireland, G. V. James
Journal: BMJ (1941)

The serum of a normal adult is generally considered to contain 9 to 11.5 mg. of calcium per 100 c.cm.Table I gives the calcium determinations of 51 cases taken at random.The blood was examined soon after admission to the Liverpool Heart Hospital.We had no knowledge of the diet calcium of these patients.It will be seen that only in 4 cases out of 51 was the serum calcium below 9 mg.
Red Cell Morphology as a Diagnostic Aid in Hematuria
Authors: Bruce S. Chang
Journal: JAMA (1984)

Dried smears of urinary sediment stained with Wright's stain were examined and compared in 20 selected patients with hematuria. In ten patients with microscopic hematuria and glomerular lesions demonstrated by renal biopsy, the urinary red cells were characteristically dysmorphic and hypochromic. This was distinctly different from the red cell morphology in ten patients with nonglomerular causes of hematuria, which was more like peripheral blood. The pathogenesis of the changes in red cell morphology seen in glomerular hematuria is unknown, but it appears not to be due to the urine composition per se. It is concluded that with some limitations, this simple, noninvasive technique may be useful in identifying a source of bleeding in the workup of hematuria.
Effects of Folic Acid Plus Vitamin B<sub>12</sub>vs Placebo in Myocardial Infarction Survivors—Reply
Authors: Jane Armitage, Robert Clarke, Rory Collins
Journal: JAMA (2010)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Detailed analysis of therapy-driven clonal evolution of TP53 mutations in chronic lymphocytic leukemia
Authors: J Malcikova, K Stano-Kozubik, B Tichy, B Kantorova, S Pavlova, N Tom, L Radova, J Smardova, F Pardy, M Doubek, Y Brychtova, M Mraz, K Plevova, E Diviskova, A Oltova, J Mayer, S Pospisilova, M Trbusek
Journal: Leukemia (2014)

In chronic lymphocytic leukemia (CLL), the worst prognosis is associated with TP53 defects with the affected patients being potentially directed to alternative treatment. Therapy administration was shown to drive the selection of new TP53 mutations in CLL. Using ultra-deep next-generation sequencing (NGS), we performed a detailed analysis of TP53 mutations' clonal evolution. We retrospectively analyzed samples that were assessed as TP53-wild-type (wt) by FASAY from 20 patients with a new TP53 mutation detected in relapse and 40 patients remaining TP53-wt in relapse. Minor TP53-mutated subclones were disclosed in 18/20 patients experiencing later mutation selection, while only one minor-clone mutation was observed in those patients remaining TP53-wt (n=40). We documented that (i) minor TP53 mutations may be present before therapy and may occur in any relapse; (ii) the majority of TP53-mutated minor clones expand to dominant clone under the selective pressure of chemotherapy, while persistence of minor-clone mutations is rare; (iii) multiple minor-clone TP53 mutations are common and may simultaneously expand. In conclusion, patients with minor-clone TP53 mutations carry a high risk of mutation selection by therapy. Deep sequencing can shift TP53 mutation identification to a period before therapy administration, which might be of particular importance for clinical trials.
Arrangements for special and intensive care of the newborn.
Authors: E Alberman, J Collingwood, P O Pharoah, J Vaizey, T E Oppe
Journal: BMJ (1977)

All the special care baby units in three Thames health regions completed a one-day census on the number of infants in the unit, staffing, and facilities. The results were assessed in the light of the recommendations of an expert group set up by the Department of Health and Social Security. Although the provision of cots (6.1-6.9 per 1000 live births) was more generous than the estimated need and the occupancy rate (59--63%) lower than suggested, some units did not have adequate trained nursing cover at night, some did not have resident paediatricians, and some lacked essential equipment. Some small units, on the other hand, had very expensive equipment that was probably underused. Relating this provision to the regional statistics on babies needing special care showed that there was room for the rationalisation of facilities for their care. Factors that should be considered in planning such care include the size of the child-bearing population, the percentage of infants of low birth weights, and the proximity of specialist paediatric and maternity units and pathology facilities. It is also essential to monitor the effectiveness of the care by assessing the outcome in babies admitted to special units, especially those of low birth weight.
MITRAL LEAFLET CHANGES FOLLOWING MYOCARDIAL INFARCTION: EVIDENCE FOR MALADAPTIVE REMODELING FAVORING ISCHEMIC MITRAL REGURGITATION
Authors: Jonathan Beaudoin, Jacob Dal-Bianco, Elena Aikawa, Joyce Bischoff, Luis Guerrero, Suzanne Sullivan, Jill Wylie-Sears, Jacob Aaron, Robert A. Levine
Journal: Journal of the American College of Cardiology (2012)
An Epidemiologic Profile of Children With Diabetes in the U.S.
Authors: Joyce M. Lee, William H. Herman, Melissa L. McPheeters, James G. Gurney
Journal: Diabetes Care (2006)

The incidence of both type 1 and type 2 diabetes in children appears to be increasing in the U.S. (1–4), likely attributable, at least for type 2 diabetes, to the emerging epidemic of childhood obesity. Unfortunately, national prevalence estimates of children with diabetes, and nationally representative data about the demographic characteristics of children with diabetes, are limited. One study, based on just 13 cases, reported the prevalence of diabetes among adolescents aged 12–19 years to be 4.1 per 1,000 (5). We used recently released data from the National Survey of Children’s Health (NSCH) to determine the prevalence of diabetes in U.S. children based on parental report and to examine the association between the presence of obesity and diabetes.

The NSCH was a population-based cross-sectional household telephone survey sponsored by the Maternal and Child Health Bureau, the National Center for Health Statistics, and the Centers for Disease Control and Prevention (6). The NSCH used random-digit dialing to recruit and survey households with children <18 years of age. One child in each household was randomly selected to be the subject of the survey, and the respondent for the interview was the parent or …
Clonidine, a New Potent Antihypertensive Agent.
Authors: Allan B. Schwartz
Journal: Annals of Internal Medicine (1971)

Meeting Abstracts1 May 1971Clonidine, a New Potent Antihypertensive Agent.Allan B. Schwartz, M.D., Virgilio Paz-Martinez, M.D., Kwan Eun Kim, M.D. (Member), Gaddo Onesti, M.D., Joel L. Chinitz, M.D., Charles Swartz, M.D., F.A.C.P.Allan B. Schwartz, M.D.Search for more papers by this author, Virgilio Paz-Martinez, M.D.Search for more papers by this author, Kwan Eun Kim, M.D. (Member)Search for more papers by this author, Gaddo Onesti, M.D.Search for more papers by this author, Joel L. Chinitz, M.D.Search for more papers by this author, Charles Swartz, M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-74-5-821_3 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptClonidine (Catapres⌖) is a new imidazoline derivative with potent antihypertensive effect. The acute hemodynamic effects of Clonidine were evaluated in seven hypertensive patients. Two distinct hemodynamic patterns are seen, depending on the position of the patient. In the supine posture cardiac output is reduced 21%, and no change occurs in peripheral vascular resistance. On tilting upright 45 deg, blood pressure is further reduced, with only minimal reduction of cardiac output; however, a 20% reduction of peripheral vascular resistance is the rule in the upright posture. The decrease in arterial blood pressure is associated with a decrease in renal vascular resistance... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: Allan B. Schwartz, M.D.; Virgilio Paz-Martinez, M.D.; Kwan Eun Kim, M.D. (Member); Gaddo Onesti, M.D.; Joel L. Chinitz, M.D.; Charles Swartz, M.D., F.A.C.P.Affiliations: Philadelphia, Pa. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byA crossover comparison of clonidine and methyldopa in hypertension 1 May 1971Volume 74, Issue 5Page: 821-821KeywordsBlood pressureCardiac outputHemodynamicsPeripheral vascular resistancePostural control ePublished: 1 December 2008 Issue Published: 1 May 1971 PDF downloadLoading ...
A Clue to Long Life?
Authors: Brian Vastag
Journal: JAMA (2002)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Pulmonary Sporotrichosis
Authors: Stewart M. Scott, E. D. Peasley, Thomas P. Crymes
Journal: New England Journal of Medicine (1961)

SPOROTRICHOSIS is an uncommon mycotic infection and pulmonary lesions are exceedingly rare. These lesions appear as necrotic foci and cavitations. Twenty cases have previously been reported, but in only 2 has the fungus been cultured from lung tissue.1 , 2 In the 2 cases presented below, both cavitary, the organism was obtained in pure culture from either cavity or necrotic lesion and was demonstrated histologically in the cavity lining of both. One of these is the only known case in which resection has been carried out.Sporotrichum, first described by Link in 1809, is a protean saprophyte of plants, insects, animals and . . .
Recurrence of spinal cord compression from extramedullary hematopoiesis in thalassemia intermedia treated with low doses of radiotherapy
Authors: Fausto Dore, Simonetta Pardini, Eleonora Gaviano, Maurizio Longinotti, Silvana Bonfigli, Stefand Rovasio, Andrea Tomiselli, Francesco Cossu
Journal: American Journal of Hematology (1993)
Ethnicity and prognosis in acute myeloid leukemia
Authors: Ronny Alcalai, Dina Ben‐Yehuda, Ilana Ronen, Ora Paltiel
Journal: American Journal of Hematology (2003)

Ethnicity has been described as a prognostic factor in breast cancer and in childhood acute lymphocytic leukemia but not in adult acute myeloid leukemia (AML). We reviewed the records of 225 consecutive AML patients who were diagnosed and treated between 1983 and 1995. Data were collected concerning demographic factors, presenting clinical features, and treatment protocols. We categorized ethnicity as follows: European Jews, non-European Jews, and Arabs. We assessed the role of ethnicity controlling for other known prognostic factors on treatment outcome and survival in this population. Older age, high leukocyte count at diagnosis, and high-risk chromosomal aberrations were significantly associated with overall survival in univariate analysis. In multivariate analysis high leukocyte count and high-risk chromosomal aberrations exerted an independent negative effect on survival. European origin was associated with longer event-free survival in univariate analysis (P = 0.024) and longer overall (P < 0.01) and event-free (P < 0.01) survival but not with a higher remission rate in multivariate analysis. For AML patients who achieved remission after induction chemotherapy and survived its complications, European origin is an independent favorable prognostic factor for long-term remission and survival in Israel. These findings may reflect better socioeconomic status, social support, increased compliance with treatment protocols, or better psychological coping mechanisms with malignancy.
Niels Finsen's treatment for lupus vulgaris
Authors: PC Gøtzsche
Journal: Journal of the Royal Society of Medicine (2011)

Niels Ryberg Finsen was born 1860 in Thorshavn, Faroe Islands, and died in 1904. He was awarded the Nobel Prize in 1903 ‘in recognition of his contribution to the treatment of diseases, especially lupus vulgaris, with concentrated light radiation, whereby he has opened a new avenue for medical science’.
PSYCHIATRIC RESIDENCY TRAINING FOR PUBLIC INSTITUTIONAL SERVICE
Authors: JULES H. MASSERMAN
Journal: American Journal of Psychiatry (1963)

Since 1959, interrelated programs were evolved at the 7 medical schools and training centers in Chicago, and the Illinois State Psychiatric Institute with its affiliated teaching facilities which have: (1) motivated and prepared residents for service in State hospitals and clinics, and (2) utilized the Institute in the continuous teaching of state hospital physicians and allied personnel. The development, vicissitudes and relative success of these programs are summarized to indicate their general applicability.
Dutch doctors should tackle female genital mutilation
Authors: Tony Sheldon
Journal: BMJ (2005)

School doctors in the Netherlands should examine the genitalia of girls aged 6, 9, and 13 years, as part of regular health checks. This is the proposal of a government advisory body to tackle the illegal practice of female genital mutilation.

The proposals are being opposed by a wide range of doctors' organisations, which say that they would damage the widespread coverage that the school health services presently achieve and would drive the problem further underground.

In its report, the Council for Public Health and Care also recommends that doctors should be legally obliged to report cases. The report estimates there are 50 cases of …
Combined mediastinal and retroperitoneal fibrosis
Authors: H. W. Salmon
Journal: Thorax (1968)

A case of combined idiopathic mediastinal fibrosis and retroperitoneal fibrosis is described. It is possibly the twelfth case to be reported during life. A review of the literature reveals the `ubiquity9 of localized collagenosis and the trend of opinion as regards aetiology and treatment.
Significance of Chronic Sinus Bradycardia in Elderly People
Authors: NEIL S. AGRUSS, ELAINE Y. ROSIN, ROBERT J. ADOLPH, NOBLE O. FOWLER
Journal: Circulation (1972)

It may be difficult to evaluate sinus bradycardia in the elderly since sinus rates below 50 beats/min may occur normally with aging. Seven asymptomatic bradycardic subjects (heart rates 41-51 beats/min), ages 67-79 years, with no evidence of impaired cardiac performance and taking no drugs, were compared with four age-matched controls (heart rates 60-84 beats/min). Autonomic function was tested with the Valsalva maneuver, amyl nitrite inhalation, methoxamine infusion, head-up tilt, and atropine intravenously (2 mg). Cardiac index at rest was normal in bradycardic subjects (2.4 ± 0.1 sem ); increased cardiac stroke volume (SV) compensated for the slow heart rate. With supine bicycle exercise, increase in cardiac output per 100 ml increase in oxygen consumption was normal in bradycardics (885 ± 60 ml compared to 907 ± 171 ml in controls). This exercise response was achieved mainly by increased SV in bradycardics and by increased heart rate in controls. Significant increases in cardiac output occurred with both atropine and atrial pacing in bradycardics, but not in controls. Autonomic impairment was not found. Increased vagal tone in bradycardics was suggested by a lesser heart rate response to exercise and passive tilting. Hence, a heart rate below 50 beats/min in elderly people does not necessarily indicate depressed cardiac performance. Further evaluation of the significance of bradycardia in these subjects requires long-term observation.
BARRIERS TO UPSTREAM ADMINISTRATION OF BIVALIRUDIN IN PATIENTS PRESENTING TO THE EMERGENCY DEPARTMENT WITH HIGH RISK NON-ST ELEVATION ACUTE CORONARY SYNDROMES
Authors: Jeanne M. Oelfke, David Larson, Scott Sharkey, Ross F. Garberich, M Nicholas Burke, Luis Pagan-Carlo, Timothy Henry
Journal: Journal of the American College of Cardiology (2012)
Reviewer's reply
Authors: D. W Denning
Journal: BMJ (1996)

EDITOR,—David Wilks and colleagues defend their book vigorously—and so they should, as it has much to commend it, as I pointed out in my review. The drug doses they quote are based on the British National Formulary and manufacturers' datasheets, but unfortunately some of these are out of date or simply incorrect. Take the recommendation that a patient with a creatinine …
Transfusion Thresholds in FOCUS
Authors: Paul J. Barr, Karen E.M. Bailie
Journal: New England Journal of Medicine (2011)

Even though red-cell transfusion is an accepted and widely used intervention, questions regarding which patients should receive transfusions and under what circumstances continue to spark debate. There has been limited evidence from clinical trials to inform policy. Meanwhile, concern about potential risks of blood transfusion and the costs of maintaining an adequate and safe blood supply1 have heightened interest in strategies to reduce the use of red-cell transfusion. These strategies include preoperative optimization of hemoglobin levels, the use of cell salvage during and after surgery, and pharmacologic interventions to reduce blood loss.In the Transfusion Trigger Trial for Functional Outcomes . . .