DEFECTIVE SERUM GAMMA GLOBULIN FORMATION
Authors: T H BREM, M E MORTON
Journal: Annals of Internal Medicine (1955)

Article1 September 1955DEFECTIVE SERUM GAMMA GLOBULIN FORMATIONTHOMAS H. BREM, M.D., M. E. MORTON, M.D.THOMAS H. BREM, M.D., M. E. MORTON, M.D.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-43-3-465 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe anomaly called agammaglobulinemia has become a fairly well known clinical entity, although prior to Bruton's report1 in 1952 it had never been described. The subject of his study was an eight year old boy who for four years had had a continuous series of bacterial and viral infections. Electrophoretic studies of the serum proteins led to the surprising discovery of complete absence of the gamma fraction in an otherwise normal serum protein pattern. Immunologic studies disclosed the complete lack of antibodies, including isohemagglutinins, and repeated challenge with a number of antigens failed to evoke an antibody response.Since then...Bibliography1. Bruton OC: Agammaglobulinemia, Pediatrics 9: 722, 1952. CrossrefMedlineGoogle Scholar2. BrutonAptGitlinJaneway OCLDCA: Absence of serum gamma globulin, Am. J. Dis. Child. 84: 632, 1952. Google Scholar3. JanewayAptGitlin CALD: Agammaglobulinemia, Tr. A. Am. Physicians 66: 200, 1953. MedlineGoogle Scholar4. GoodVarco RARL: Successful homograft of skin in a child with agammaglobulinemia, J. A. M. A. 157: 713 (Feb. 26) 1955. CrossrefMedlineGoogle Scholar5. HaylesSticklerMcKenzie ABGBBF: Decrease in serum gamma globulin (agammaglobulinemia): report of three cases, Pediatrics 14: 449, 1954. MedlineGoogle Scholar6. KeidanMcCarthyHaworth SEKJC: Fatal generalized vaccinia with failure of antibody production and absence of serum gamma globulin, Arch. Dis. Childhood 28: 110, 1953. CrossrefMedlineGoogle Scholar7. PrasadKoza ASDW: Agammaglobulinemia, Ann. Int. Med. 41: 629, 1954. LinkGoogle Scholar8. GrantWallace GHWD: Agammaglobulinemia, Lancet 2: 671 (Oct. 2) 1954. CrossrefGoogle Scholar9. SanfordFavourTribeman JPCBMS: Absence of serum gamma globulins in an adult, New England J. Med. 250: 1027 (June 17) 1954. CrossrefMedlineGoogle Scholar10. SternReiner KGM: Electrophoresis in medicine, Yale J. Biol. and Med. 19: 67, 1947. Google Scholar11. ArendsCoonradRundles TEVRW: Serum proteins in Hodgkin's disease and malignant lymphoma, Am. J. Med. 16: 833, 1954. CrossrefMedlineGoogle Scholar12. RundlesCoonradArends RWEVT: Serum proteins in leukemia, Am. J. Med. 16: 842, 1954. CrossrefMedlineGoogle Scholar13. PetermannKarnofskyHogness MLDAKR: Electrophoretic studies on the plasma proteins of patients with neoplastic disease. III. Lymphomas and leukemia, Cancer 1: 109, 1948. CrossrefMedlineGoogle Scholar14. BrownReadWisemanFrance RKJTBKWG: The electrophoretic analysis of serum proteins of the blood dyscrasias, J. Lab. and Clin. Med. 33: 1523, 1948. MedlineGoogle Scholar15. Adams WS: Personal communication. Google Scholar16. Wintrobe M: Personal communication. Google Scholar17. AdamsAilingLawrence WSELJS: Multiple myeloma: its clinical and laboratory diagnosis with emphasis on electrophoretic abnormalities, Am. J. Med. 6: 141, 1949. CrossrefMedlineGoogle Scholar18. Krebs EG: Depression of gamma globulin in hypoproteinemia due to malnutrition, J. Lab. and Clin. Med. 31: 85, 1946. MedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Los Angeles, California*Presented at the Thirty-sixth Annual Session of the American College of Physicians, Philadelphia, Pennsylvania, April 28, 1955.From the Departments of Medicine, University of Southern California and University of California Schools of Medicine, Los Angeles, and the Veterans Administration Hospital, Long Beach, California.†Present address: 6515 Wilshire Boulevard, Los Angeles, California. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byCurrent genetic landscape in common variable immune deficiencyHow Common Variable Immune Deficiency has Changed Over Six DecadesInherited Predisposition to Chronic Lymphocytic LeukemiaDisease activity and pretreatment, rather than hypogammaglobulinaemia, are major risk factors for infectious complications in patients with chronic lymphocytic leukaemiaGenetic susceptibility to chronic lymphocytic leukemiaHistorical aspects of chronic lymphocytic leukaemiaHistorical aspects of chronic lymphocytic leukaemiaFamilial chronic lymphocytic leukaemia: a survey and review of published studiesCombined immunodeficiency preceding chronic lymphocytic leukemiaGenetically determined immunodeficiency diseases (GDID) and malignancy: Report from the Immunodeficiency-Cancer RegistryStörungen der InfektionsresistenzImmunodepression and MalignancyThe Neoplastic ImmunoglobulinopathiesLymphoreticular malignancy in immunodeficiency with lymphocytotoxic antibodyPrimary immunodeficiency diseases and cancer: The immunodeficiency-cancer registryImmunodeficiency And CancerAGAMMAGLOBULINÆMIA WITH B LYMPHOCYTES SPECIFIC DEFECT OF PLASMA-CELL DIFFERENTIATIONOccurrence of malignancy in immunodeficiency diseases: A literature reviewXXXVIII Current Concepts of Central Lymphoid Tissues in ImmunologyHyperthermia, Fever and Infectious DiseasesTHE ROLE OF THE THYMUS AND BURSA OF FABRICIUS IN THE DEVELOPMENT OF EFFECTOR MECHANISMS*Hypogammaglobulinemia and steatorrheaThe pathogenesis of immunologic deficiency diseasesAdult hypogammaglobulinemiaPrimary "Acquired" HypogammaglobulinemiaAcquired Hypogammaglobulinæmia Complicated by ReticulosarcomaReaginic AntibodiesThe occurrence of rheumatoid factor and other abnormalities in families of patients with agammaglobulinemiaPulmonary Pneumocystis carinii infectionAntibodies to Blood Group A and B Substances in ReticulosesA Family with Several Cases of HypogammaglobulinaemiaPrimary Acquired Agammaglobulinemia, with a Family History of Collagen Disease and Hematologic DisordersThe Minor CrossmatchCIRCULATING ANTIBODIES IN RETICULOSESChronic Lymphocytic Leukemia�ber seltener vorkommende Ver�nderungen der Serumeiwei�-Zusammensetzung bei verschiedenartigen klinischen SyndromenÜber die Bedeutung der Hypo-Gamma-Globulinämie bei ErwachsenenIdiopathic Acquired Agammaglobulinemia Associated with ThymomaFamilial hypogammaglobulinemia, splenomegaly and leukopeniaHOST-PARASITE RELATIONSHIPS IN PATIENTS WITH DYSPROTEINEMIASHypogammaglobulinemia and chronic lymphatic leukemiaPrognostische Bemerkungen zum AntikörpermangelsyndromEin Fall von A-?-Globulin�mie und Bronchioektasie im KindesalterAdult agammaglobulinemia associated with multiple congenital anomaliesDysproteinemiaAcquired Hypogammaglobulinaemia in an AdultHereditary Obesity: Relation to Serum Lipoproteins and Protein Concentrations in SwineAgammaglobulinemia in two Brothers.1 1 September 1955Volume 43, Issue 3Page: 465-479KeywordsAntibody productionAntigensChronic hepatitisGlobulinsHospital medicineLymphomaPathogenesisProteinsSerum proteinsUpper respiratory tract infections ePublished: 1 December 2008 Issue Published: 1 September 1955 PDF downloadLoading ...