NICOTINIC ACID IN THE TREATMENT OF CERTAIN DEPRESSED STATES: A PRELIMINARY REPORT
Authors: A C WASHBURNE
Journal: Annals of Internal Medicine (1950)

Article1 February 1950NICOTINIC ACID IN THE TREATMENT OF CERTAIN DEPRESSED STATES: A PRELIMINARY REPORTANNETTE C. WASHBURNE, M.D., F.A.C.P.ANNETTE C. WASHBURNE, M.D., F.A.C.P.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-32-2-261 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptINTRODUCTIONThe increasing scope of psychosomatic medicine has reëmphasized the inter-relationship of psyche and soma in the production of various pathologic disorders.Alterations in certain physiologic processes are evident in such conditions as schizophrenia, manic depressive reactions, benign depressions, and tension-anxiety states. Among these alterations, changes in body temperature, endocrine functions, biochemical factors, and the circulatory system have been observed. Investigations have suggested that such alterations may prove of etiologic significance in the production of certain of the above mentioned syndromes. These investigations, while highly interesting, have on the whole been inconclusive and not infrequently at variance. These contradictions, although...Bibliography1. Lewis N: The constitutional factors in dementia praecox, Nerv. and Ment. Dis. Monograph No. 35, 1923. Google Scholar2. Lewis N: Pathology of mental disease, New York State J. Med. 36: 1101, 1936. Google Scholar3. FarrelVassaf MJE: Effect of insulin shock on heart and blood pressure in treatment of schizophrenia, Arch. Neurol. and Psychiat. 43: 784, 1940. CrossrefGoogle Scholar4. Schrijver-Hertzberger S: Ueber das Capillarbild bei Psychosen, Ztschr. f. d. ges. Neurol. u. Psychiat. 141: 261, 1932. CrossrefGoogle Scholar5. FinkelmanHaffron ID: Estimation of circulating blood volume in schizophrenia, a preliminary report, Elgin Papers 2: 73, 1936. Google Scholar6. RosenbaumRosemanAringFerris MECJE: Intracranial blood flow in dementia paralytica cerebral atrophy and schizophrenia, Arch. Neurol. and Psychiat. 47: 793, 1942. CrossrefGoogle Scholar7. Klingmann T: Physical signs in schizophrenia, Am. J. Psychiat. 103: 69, 1946. CrossrefMedlineGoogle Scholar8. JungCarmichael REA: Vasomotor reaction and heart regulation in catatonic stupor, Arch. f. Psychiat. 107: 300, 1937. CrossrefGoogle Scholar9. HimwichBowmanWortisFazekas HEKMJJF: Biochemical changes occurring in the cerebral blood during the insulin treatment of schizophrenia, J. Nerv. and Ment. Dis. 89: 273, 1939. CrossrefGoogle Scholar10. HimwichCameronHomburgerFeldman HEDEEF: Cerebral metabolism in patients with depression, Am. J. Psychiat. 3: 453, 1945. CrossrefGoogle Scholar11. Hoskins RG: The biology of schizophrenia, 1946, W. W. Norton Co. Google Scholar12. LandisHunt CWA: Adrenalin and emotion, Psychol. Rev. 34: 467, 1932. CrossrefGoogle Scholar13. Schmidt W: Reactivity to ephedrine in dementia praecox, München. med. Wchnschr. 61: 366, 1914. Google Scholar14. Cameron DE: Objective and experimental psychiatry, 2 Ed., 1941, MacMillan Co., page 271. Google Scholar15. CleckleySydenstrickerGeislin HMVPLE: Nicotinic acid in the treatment of atypical psychotic states associated with malnutrition, J. A. M. A. 112: 2107, 1939. CrossrefGoogle Scholar16. SydenstrickerCleckley VPHM: The effect of nicotinic acid in stupor, lethargy, and various other psychiatric disorders, Am. J. Psychiat. 98: 83, 1941. CrossrefGoogle Scholar17. Ibid, page 89. Google Scholar18. Ibid, page 90. Google Scholar19. Ibid, page 92. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Madison, Wisconsin*Received for publication November 11, 1948.From the Neuropsychiatric Service, Department of Preventive Medicine and Student Health, University of Wisconsin Medical School. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byAntidepressants: Clinical discoveries with antidepressant drugsMixtures modeling identifies vitamin B1 and B3 intakes associated with depressionPharmacologic Use of NiacinHeinz Lehmann Introduces ImipramineNicotinic Acid and Depression: Depression Following Cessation of Nicotinic Acid UseNicotinic Acid and PsychiatryImipramine a Clinical Evaluation in a Variety of SettingsThe Treatment of Depressive Conditions with Imipramine (G 22355)Nutritional Deficiencies and Emotional DisturbancesTHE USE OF VITAMIN THERAPY TO REVERSE CERTAIN CONCOMITANTS OF AGING†A NEWER METHOD OF NICOTINIC ACID THERAPY IN HEADACHE OF THE VASOCONSTRICTIVE TYPE†The Role of Nicotinic Acid (Niacin) in Mental Health and DiseaseNICOTINIC ACID IN THE TREATMENT OF DEPRESSION*W. L. TONGE, M.B. (Manc.) D.P.M. (Lond.) 1 February 1950Volume 32, Issue 2Page: 261-269KeywordsBipolar disorderNiacinPreventive medicineSchizophreniaTemperature ePublished: 1 December 2008 Issue Published: 1 February 1950 PDF downloadLoading ...