HEPATIC INSUFFICIENCY. I. PATHOPHYSIOLOGY AND CLINICAL ASPECTS
Authors: S S LICHTMAN
Journal: Annals of Internal Medicine (1946)

Article1 September 1946HEPATIC INSUFFICIENCY. I. PATHOPHYSIOLOGY AND CLINICAL ASPECTSS. S. LICHTMAN, M.D., F.A.C.P.S. S. LICHTMAN, M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-25-3-453 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptExposure to exotic diseases and infectious hepatitis of members of the armed forces necessitates reëvaluation of concepts of hepatic insufficiency by physicians. Recognition of relative hepatic insufficiency is not on a par with the diagnosis of insufficiency in other organs, and many physicians do not concern themselves with the liver until overt jaundice appears. Sensitive biochemical methods reveal that impaired liver function is far more common than previously suspected. The immense recuperative power of the liver masks the insufficiency until the parenchyma fails to eliminate bilirubin.Mass wartime experience has firmly established the clinical and biochemical attributes of hepatic insufficiency...Bibliography1. BARKERCAPPSALLEN MHRBFW: Acute infectious hepatitis, Jr. Am. Med. Assoc., 1945, cxxviii, 997-1003. CrossrefGoogle Scholar2. FINKSBLUMBERG RHRW: Epidemic hepatitis with and without jaundice, Arch. Int. Med., 1945, lxxvi, 102-113. CrossrefGoogle Scholar3. POLLOCK MR: Pre-icteric stage of infective hepatitis, Lancet, 1945, ii, 626. CrossrefGoogle Scholar4. RENNIE JB: Infective hepatitis with special reference to prognosis, Am. Jr. Med. Sci., 1945, ccx, 18-29. CrossrefGoogle Scholar5. BENJAMINHOYT JERC: Disability following postvaccinal (yellow fever) hepatitis, Jr. Am. Med. Assoc., 1945, cxxviii, 319-324. CrossrefGoogle Scholar6. CARAVATI CM: Posthepatitis syndrome, South. Med. Jr., 1944, xxxvii, 251. CrossrefGoogle Scholar7. BARKERCAPPSALLEN MHRBFW: Chronic hepatitis in the Mediterranean theatre, Jr. Am. Med. Assoc., 1945, cxxix, 653. CrossrefGoogle Scholar8. SNELLWOODMEINENBERG AMDAJ: Infectious hepatitis with especial reference to its occurrence in wounded men, Gastroenterology, 1945, v, 241. Google Scholar9. KEEFERFRIES CSED: The fatty liver, its diagnosis and clinical course, Trans. Assoc. Am. Phys., 1942, lvii, 283. Google Scholar10. LAWRENCE JS: Subacute necrosis of the liver without icterus, Lancet, 1946, ii, 41. CrossrefGoogle Scholar11. SNELL AM: Clinical aspects of portal cirrhosis, Ann. Int. Med., 1931, v, 338. Google Scholar12. STOKESOWENHOLMES JFJREG: Neurological complications of infective hepatitis, Brit. Med. Jr., 1945, i, 477. Google Scholar13. BYRNETAYLOR EAGF: An outbreak of jaundice with signs in the nervous system, Brit. Med. Jr., 1945, i, 477. CrossrefGoogle Scholar14. WOOLEY DW: Some new aspects of the relationship of chemical structure to biological activity, Science, 1944, c, 579-583. CrossrefGoogle Scholar15. COMFORTHOYNE MWRM: Constitutional hepatic dysfunction: clinical study of 35 cases, Gastroenterology, 1944, iii, 155-162. Google Scholar16. MANN FC: I. Studies in the dehepatized animal. II. Restoration and pathologic reactions of the liver, Jr. Mt. Sinai Hosp., 1944, xi, 1-22, 65-73. Google Scholar17. WACHSTEIN M: Influence of dietary deficiencies and various poisons on the histochemical distribution of phosphatase in the liver, Arch. Path., 1945, xl, 57-67. Google Scholar18. GLASSEDMONDSONSOLL SJHASN: Excretion of estrogen after the injection of estradiol and estrone into men with cirrhosis of the liver, Jr. Clin. Endocrinol., 1944, iv, 54-57. CrossrefGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: New York, N. Y.*Based on Lectures on the Pathophysiology of the Liver, delivered at the Cornell University Medical College, Department of Physiology, November 23, 1945, and on the Clinical Aspects of Hepatic Insufficiency, in the Blumenthal Auditorium, the Mount Sinai Hospital, April 3, 1946. Received for publication June 29, 1946. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byDigestive SystemNeedle Biopsy of the LiverExperience with needle liver biopsies at the hepatitis center for Japan and Korea, 1950–1951The Clinical Significance of AminoaciduriaNeurological Complications in Acute Infectious Hepatitis.Hazards in the Therapeutic Use of MorphineCurrent Concepts of Jaundice, with Particular Reference to HepatitisHomologous serum hepatitis following transfusion in an infantACUTE HEPATITIS: NOTES ON VIRAL AND OTHER TYPES1 1 September 1946Volume 25, Issue 3Page: 453-465KeywordsArmed forcesBilirubinInfectious diseasesInfectious hepatitisLiver ePublished: 1 December 2008 Issue Published: 1 September 1946 PDF downloadLoading ...