tbuckley/cabot-search huggingface dataset:
Biochemical indices of vitamin B<sub>12</sub> nutrition in pregnant patients with subnormal serum vitamin B<sub>12</sub> levels
Authors: Jack Metz, Katherine McGrath, Michael Bennett, Keith Hyland, Teodoro Bottiglieri
Journal: American Journal of Hematology (1995)

Abstract To determine the significance of the commonly observed fall in serum vitamin B 12 levels during pregnancy, serum levels of the B 12 metabolites methylmalonic acid (MMA) and homocysteine (Hcy) were measured in a group of 50 pregnant patients with subnormal serum B 12 (range 45‐199 pg/ml) and the results compared with those of 25 pregnant controls (serum B 12 208‐580 pg/ml). Mean values for serum MMA and total Hcy in the subnormal B 12 group were 445.4 nmol/L and 7.03 μmol/L, respectively, which were not significantly different from the mean MMA of 440.5 nmol/L and Hcy of 6.88 nmol/L in the controls. For the total group of patients, neither serum MMA nor serum Hcy levels correlated with serum B 12 . One‐third of pregnant patients showed elevated serum MMA values, independent of B 12 status. Significant elevation of serum Hcy was detected in only two patients, both with subnormal serum B 12 and hematological evidence of B 12 deficiency. We conclude that the usual fall in serum B 12 concentration in pregnancy does not reflect B 12 deficiency at the biochemical level. In establishing true B 12 deficiency in pregnancy, the serum Hcy level (in the absence of folate deficiency) but not serum MMA, is of value. © 1995 Wiley‐Liss, Inc.
Nucleation of calcium oxalate crystals by albumin: Involvement in the prevention of stone formation
Authors: Claire Cerini, Sophie Geider, Bertrand Dussol, Carole Hennequin, Michel Daudon, Stéphane Veesler, Serge Nitsche, Roland Boistelle, Patrice Berthézène, Patricia Dupuy, Alain Vazi, Yvon Berland, Jean-Charles Dagorn, Jean-Michel Verdier
Journal: Kidney International (1999)
Antiphospholipid antibodies: a risk factor for occlusive ocular vascular disease in systemic lupus erythematosus and the 'primary' antiphospholipid syndrome.
Authors: R A Asherson, P Merry, J F Acheson, E N Harris, G R Hughes
Journal: Annals of the Rheumatic Diseases (1989)

Seven cases of occlusive ocular vascular disease affecting retinal and choroidal vessels were found among 84 consecutive patients with raised levels of anticardiolipin antibodies attending the lupus arthritis clinic at St Thomas's Hospital from 1985 to 1987. Six patients with systemic lupus erythematosus (SLE) and one with a 'primary antiphospholipid syndrome' had occlusive ocular vascular disease affecting a variety of vessels. This gives a prevalence of occlusive ocular vascular disease of 8% in this subgroup of patients, significantly higher than the 0.5-2.0% previously reported in patients with SLE. Four of these patients also suffered from cerebrovascular disease, supporting the previously documented association between occlusive ocular vascular disease and central nervous system disease in SLE. Additionally, other features of the antiphospholipid syndrome were frequently present. These findings suggest that patients with SLE and raised anticardiolipin antibodies have a higher risk of developing occlusive ocular vascular disease than has been previously reported.
Clinical Depressions Among Negroes
Authors: CLIVE M. TONKS, EUGENE S. PAYKEL, GERALD L. KLERMAN
Journal: American Journal of Psychiatry (1970)

In the psychiatric literature, depressions among Negroes have been associated more with somatic complaints and less with guilt and suicidal trends. To test this concept, a comparison was made of 31 Negro and 187 white depressed patients. Initial comparisons, controlled for social class, showed differences on six individual symptom ratings. Further analysis indicated that the principal difference lay in generally less severe illness among Negro patients rather than less specific features. Possible explanations are discussed.
Relevance of location of defect and pulmonary vascular resistance to the intracardiac pattern of left-to-right shunt flow in dogs with experimental ventricular septal defect.
Authors: S Okubo, M Nakai, T Tomino
Journal: Circulation (1986)

Left-to-right (L-R) shunting across a ventricular septal defect (VSD) often involves a direct VSD-pulmonary arterial component (jet) that surges from the VSD immediately into the pulmonary artery. We used the thermodilution technique in dogs with acute experimental VSD to quantify this component. In dogs with supracristal VSD (n = 7), the direct component represented 76 +/- 4% (mean +/- SE) of the total L-R shunt on average, vs 39 +/- 7% (p less than .001) of the total in dogs with infracristal VSD and the same level of L-R shunting (n = 6). The direct component can be expected to impose additional hyperkinetic forces on the pulmonary artery since it is driven by the left ventricular pressure. Although not yet clinically proven, we speculate therefore that patients with supracristal VSD may be at greater risk of becoming jeopardized by late-onset pulmonary vascular obstructive disease. Since a part of the total shunt other than the direct component dropped into the right ventricle, the right ventricle bore only 24% of the total shunt in supracristal VSD, but 61% in infracristal VSD. We also found that the amount of direct component was decreased, and therefore another part must have increased, as the pulmonary vascular resistance was artificially raised. As a second speculation, therefore, we suggest that patients with supracristal VSD may have less enlargement of the right ventricle than those with infracristal VSD before pulmonary hypertension develops.
THE RECENT PLAGUE CASES IN SUFFOLK
Authors: H. H. Brown
Journal: BMJ (1910)

repapered or distempered.The destruction and disposal of rats over a wide area was undertaken by the sanitary authority, willingly assisted by the public, and this is meanwhile being done methodically and with excellent results.I am indebted to Dr. Carey of Holbrook for notes on the cases in C.'s family; to Dr.
Form follows function in visual information processing
Authors: Richard Latto
Journal: Behavioral and Brain Sciences (2004)

Understanding neural anatomy and physiology depends on first understanding the behaviour being mediated. Glover, in his review of earlier work suggesting various dichotomies in visual processing, shows how there is a tendency to oversimplification if this approach is ignored. His own new proposals demonstrate the advantages of allowing function to drive anatomical analysis. Nevertheless, the new planning–control dichotomy he proposes, though a valuable advance, is itself an oversimplification of what must be a multi-channel system.
Langerhans cells are not required for graft-versus-host disease
Authors: Hongmei Li, Daniel H. Kaplan, Catherine Matte-Martone, Hung Sheng Tan, Srividhya Venkatesan, Kody Johnson, Anthony J. Demetris, Jennifer McNiff, Mark J. Shlomchik, Warren D. Shlomchik
Journal: Blood (2010)
The Pathology of Ganglion
Authors: W. G. Spencer
Journal: BMJ (1891)

Has had pain in the lumbar region for three years.A tender spot present at the level of thle iliac crest.No prominenit spinlous processes.Ilas noticed a swelling in the thigh for the last fortnighit.Present condition: Smooth and rounded swelling on the inner side of the femoral vessels.August 7th.Aspirated, 6 ounces of pus removed, cavity in- jected with 1 ounice of iodoform solution.August 21st.Aspirated, 10 ounces of pus removed, again in-
Mycosynthesis, characterization and antibacterial properties of AgNPs against multidrug resistant (MDR) bacterial pathogens of female infertility cases
Authors: Ponnusamy Manogaran Gopinath, Ganesan Narchonai, Dharumadurai Dhanasekaran, Anandan Ranjani, Nooruddin Thajuddin
Journal: Asian Journal of Pharmaceutical Sciences (2014)

Recently, biosynthesis of silver nanoparticles using bacteria, fungus and plants has emerged as a simple and viable alternative to more complex physical and chemical synthetic procedures. The present investigation explains rapid and extracellular synthesis of silver nanoparticles using fungus Fusarium oxysporum NGD and characterization of the synthesized silver nanoparticles using UV-Vis spectroscopy, scanning electron microscopy, energy dispersive spectroscopy and X-ray diffraction analysis. The size range of the synthesized silver nanoparticles was around 16.3–70 nm. The FTIR studies showed major peaks of proteins involved in the synthesis of silver nanoparticles. Further, antibacterial effect of the silver nanoparticles against multidrug resistant pathogens Enterobacter sp. ANT 02 [HM803168], Pseudomonas aeruginosa ANT 04 [HM803170], Klebsiella pneumoniae ANT 03 [HM803169] and Escherichia coli ANT 01 [HM803167] was tested using turbidometric assay at 10, 20, 30, 40 μg AgNPs/ml alone and in combination with ampicillin using agar well diffusion assay. All the resistant bacteria were found to be susceptible to the antibiotic in the presence of the silver nanoparticles.
Altered mineral metabolism in glucocorticoid-induced osteopenia. Effect of 25-hydroxyvitamin D administration.
Authors: T J Hahn, L R Halstead, S L Teitelbaum, B H Hahn
Journal: Journal of Clinical Investigation (1979)

Parameters of mineral and bone metabolism were studied in 17 patients treated chronically with supraphysiologic doses of glucocorticoids. When compared to 15 matched normal subjects, the patient group exhibited similar serum 25-hydroxyvitamin D (25-OHD) levels, decreased intestinal 47Ca absorption, increased serum immunoreactive parathyroid hormone, and decreased forearm bone mass. Iliac crest bone biopsies revealed a decreased bone formation rate and increased osteoclast number. Treatment with 25-OHD (mean dose 4.03 micrograms/d) and calcium (500 mg/d) in nine patients produced a 46% increase in 47Ca absorption (P less than 0.001) and a 54% decrease in serum immunoreactive parathyroid hormone (P less than 0.001) by 3 mo. In addition, by 12 mo the treatment group exhibited (a) a 13.2 +/- 5.1% increase in metaphyseal (P less than 0.001) and a 2.1 +/- 0.4% increase in diaphyseal (P less than 0.05) forearm bone mass, and (b) significant decreases in cortical and endosteal osteoclast number. Biochemical and bone mass changes persisted through 18 mo. No significant changes in any parameter occurred in eight control patients administered calcium 100 mg/d. It is concluded that treatment with 25-OHD and calcium can significantly improve parameters of mineral and bone metabolism in patients with glucocorticoid-induced osteopenia.
Communicating With Deaf Patients
Authors: Adam O. Goldstein
Journal: JAMA (1995)

<h3>To the Editor.</h3> —A recent encounter with a deaf patient in my office identified a previously underused resource for increasing communications between deaf patients and their physicians. A 30-year-old employee of a local computer manufacturing company came to my office recently with a history of deafness since childhood, secondary to meningitis. After realizing the great difficulty that we would have in regular communications, particularly on follow-up telephone conversations, which might form the heart of her true needs, she asked me if I was on electronic mail (E-mail). I indicated that I was, and she suggested therefore that we communicate by E-mail. This has a proved a highly desirable form of communication for this particular patient for several reasons. She can communicate with me at any time and can be assured that I will get the message. I can also respond as needed and with sufficient detail. We are subsequently forming
Fungal arthritis simulating juvenile rheumatoid arthritis.
Authors: J Haapasaari, R V Essen, A Kahanpaa, A A Kostiala, K Holmberg, J Ahlqvist
Journal: BMJ (1982)

Petriellidium boydii is often isolated from maduromycosis but has recently been associated with arthritis. A previously healthy 6-year-old boy developed chronic purulent arthritis of the knee after a bicycle accident. Culture of aspirate grew no pathogens and antibiotic treatment had no effect. Culture of synovial fluid grew P boydii, which responded initially to amphotericin but reappeared after six months. Subsequent treatment with miconazole was stopped after development of haematuria. The fungus was sensitive to ketoconazole, and treatment with this drug cured the infection. With the introduction of ketoconazole it is of practical importance to recognise fungal infections.
Array-based DNA methylation profiling in follicular lymphoma
Authors: C O'Riain, D M O'Shea, Y Yang, R Le Dieu, J G Gribben, K Summers, J Yeboah-Afari, L Bhaw-Rosun, C Fleischmann, C A Mein, T Crook, P Smith, G Kelly, A Rosenwald, G Ott, E Campo, L M Rimsza, E B Smeland, W C Chan, N Johnson, R D Gascoyne, S Reimer, R M Braziel, G W Wright, L M Staudt, T A Lister, J Fitzgibbon
Journal: Leukemia (2009)
THE TREATMENT OF INSOMNIA
Authors: R. D. Rudolf
Journal: BMJ (1922)

Tim 377 of the radiologists, and that surgery will be less and less enlisted in the future for its treatment.The Radium Institute results in this complaint are very encouraging.Tonsillar Anaemia.Considerable difference of opinion still exists as to the wisdom of completely extirpating the tonsils, some claiming that an anaemia results from the removal of these haemo- poietic organs.There are therefore advocates of the slicing or guillotine operation as against the thorough enucleation.My own experience leads me to adopt the enucleation plan, as less liable to be followed by recurrence of the lhypertrophy.Aside from the primary or recurrent haemorrhage at the time of operation, which may be copious and account for a temporary marked anaemia, I lave not seen a chronic anaemia result after enucleation that would deter me from ablating these small lhaemopoietic glands, whliih are so often removed with manifest advantage to tlle patient.Haemolytic Jaundice.This is a peculiar acholuric jaundice, whiclh may be either congenital or acquired, and whiich may last for years; it is a slow blood disease, witli marked anaemia from destruction of red blood cells.In this disease splenectomy has a high curative value, and may arrest the disease quite promptly and satisfactorily.
ISOLATION FROM NORMAL MICE OF A PNEUMOTROPIC VIRUS WHICH FORMS ELEMENTARY BODIES
Authors: Clara Nigg, Monroe D. Eaton
Journal: The Journal of Experimental Medicine (1944)

1. A pneumotropic virus which forms elementary bodies has been isolated from apparently normal albino Swiss mice. 2. The antigenic relationship of this virus to those of meningopneumonitis, lymphogranuloma venereum, hamster pneumonia (7), and human pneumonitis (8) was established either by cross-immunity or complement fixation or both. 3. In spite of a relationship to other viruses, the virus could be differentiated from all the others studied by certain of its properties.
Tailoring hospital facilities to needs.
Authors: A J Cavenagh
Journal: BMJ (1982)

and no case has yet manifested pelvic wall or suture-line disease.None of these cases has received either cytotoxic or radiotherapeutic adjuvant therapy.Our figures suggest that all but a minority of rectal cancers may be controlled locally by refinement of surgical technique.If this is so we might most profitably direct the adjuvant treatments towards the abortion of hepatic micrometastases in the manner which has been advocated by Taylor and others.2It is surely desirable that we should approach this slow-growing and often localised disease in a stepwise manner and evaluate each modality in turn.In particular trials of adjuvant therapy are unlikely to bear fruit until the surgical technique has been standardised so that we may compare like with like.
"Bush meat" Threat
Authors: Joan Stephenson
Journal: JAMA (2002)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
CANCER CONTROL IN WESTCHESTER
Authors: GEORGE C. ADIE
Journal: JAMA (1942)

This paper presents a discussion of an actual practice directed toward the control of cancer in Westchester County, N. Y., population, half a million, an experiment the virtues of which have created a considerable interest abroad while developing within the county great comfort to members of families of low income and help to doctors in the care of patients usually encountered in distressing circumstances. In 1928 Dr. Howard Canning Taylor Sr., then president of the American Society for the Control of Cancer, conceived the idea of extending the activities of that organization beyond cities possessing machinery for cancer education to sections of the country having no such equipment, hoping to develop a more optimistic attitude toward the outcome of the cancer diseases and to spread to adult populations such educational aids as might lead toward a recognition of the threat of cancer on the appearance of early symptoms. With this
Blood Lead Levels
Authors: John W. Graef
Journal: JAMA (1987)

<h3>To the Editor.—</h3> I read with interest the editorial entitled "Now Read This: The SI Units Are Here," published in the May 2, 1986, issue of<i>JAMA</i>.<sup>1</sup>In Table 3—"Examples of Conversions to Système International (SI) Units"—I was concerned to find values for lead in blood that may be confusing to clinicians. Although the authors have provided a disclaimer in their footnote on page 2339, disclaimers are not usually read, and, because the acceptable level of lead in blood has been revised downward over the past 15 years, there are still many clinicians who use older values. Contrary to the value of greater than 60 μg/dL (&gt;2.90 μmol/L) listed, the Centers for Disease Control in 1985 recommended 25 μg/dL (1.20 μmol/L) as the upper limit of acceptable values for defining lead poisoning in children. While this value has not been clearly defined in adults, most clinicians who work in
Student elective in Papua New Guinea
Authors: N G Patil
Journal: BMJ (1982)

prenatal life.Psalm 139 speaks of God's care and concern for the developing embryo.5It is clear that the unborn child is regarded in scripture as a unique and specific individual from the earliest days of pregnancy.6-There are no grounds, biological or biblical, for a careless or shallow view of the value of human life or the contention that the zygote is not a human being.A leading article in a recent Christian Medical Fellowship quarterly newsletter con- cludes: "We should be constantly affirming God's abiding principles for man as stewards of His creation.Christians are rightly in the forefront of science.Man was ordained to control and replenish the earth.We can adequately discharge this responsibility only through constant reference to the Creator's objectives and His principles by which man is to relate to man....The ability to perform is not license to do.Each test-tube test must itself be tested by those laws which on Judgment Day will inexorably test every man." 9
Wavering in the breeze: is multiple breath washout useful in primary ciliary dyskinesia?
Authors: A. Bush, S. Irving
Journal: Thorax (2015)

It has long been known that first second forced expired volume (FEV1) is insensitive both to distal airway disease and also structural lung disease as measured by high-resolution CT (HRCT).1 Furthermore, monitoring airway diseases has become harder as successful therapies have limited the rate of deterioration, making change in FEV1 less and less useful in clinical practice and as an endpoint in randomised controlled trials. Accordingly, we have had to deploy novel measures (or in the case of multiple breath washout (MBW), rediscovered old techniques). The use of MBW to calculate lung clearance index (LCI) and calculate other, more sophisticated phase 111 analyses has taken off in the last decade or so. The most salient data have come from cystic fibrosis (CF). LCI has been shown in cross-sectional studies to be abnormal more often than spirometry or plethysmography;2 ,3 in longitudinal studies, LCI becomes abnormal before these other measures;4 it predicts future lung function5 and CF lung attacks;6 it is sensitive to interventions such as treatment of a CF lung attack with intravenous antibiotics;7 and has been used as an endpoint in randomised controlled trials,8–10 particularly in children in whom spirometry is normal or nearly normal.11 Cross-sectional comparisons with HRCT have shown that LCI is very sensitive to structural airway wall disease12 ,13 and can reduce the number of HRCT scans in the CF clinic. Furthermore, the normal values of LCI flat line throughout life, other than slight rises in the very young14 and the elderly.15 LCI clearly has limitations—there is no signal from areas of the lung that are unventilated or …
Retrognathia and Sleep Apnea
Authors: Norman K. Imes
Journal: JAMA (1977)

The association of sleep apnea with daytime hypersomnolence without obesity, and its potentially lethal cardiopulmonary sequelae, make it crucial that this condition be distinguished from narcolepsy. A patient with retrognathia who had been diagnosed as a narcoleptic for 15 years had the primary complaint of excessive daytime sleepiness. Sleep laboratory evaluation showed severe hypoxemia and a mean of 366 upper airway obstructions per night. The patient was treated with a tracheotomy; this resulted in relief of the sleep-related upper airway obstructions, hypoxemia, and hypersomnolence.