ADRENAL MEDULLARY TUMOR (PHEOCHROMOCYTOMA) AND DIABETES MELLITUS; DISAPPEARANCE OF DIABETES AFTER REMOVAL OF THE TUMOR
Authors: Leroy E. Duncan, James H. Semans, John Eager Howard
Journal: Annals of Internal Medicine (1944)

Case Reports1 May 1944ADRENAL MEDULLARY TUMOR (PHEOCHROMOCYTOMA) AND DIABETES MELLITUS; DISAPPEARANCE OF DIABETES AFTER REMOVAL OF THE TUMORLEROY E. DUNCAN JR., M.D., JAMES H. SEMANS, M.D., JOHN EAGER HOWARD, M.D.LEROY E. DUNCAN JR., M.D., JAMES H. SEMANS, M.D., JOHN EAGER HOWARD, M.D.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-20-5-815 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe clinical picture associated with tumors composed of tissue morphologically and functionally similar to that of the adrenal medulla has been fairly well defined.1, 2, 3The cardinal feature of this entity is hypertension, usually paroxysmal. As one would expect, there is frequently evidence that carbohydrate metabolism is abnormal. We have recently observed a patient with an adrenal pheochromocytoma in whom the disturbance of carbohydrate metabolism was so severe that he was followed for several years in our Diabetic Clinic as a characteristic case of diabetes mellitus. Even after the diagnosis of pheochromocytoma had been established, it was thought that...Bibliography1. BELTPOWELL AEO: Clinical manifestations of the chromaffin cell tumors arising from the suprarenal medulla, Surg., Gynec., and Obst., 1934, lix, 9. Google Scholar2. WELLSBOMAN AHPG: The clinical and pathologic identity of pheochromocytoma, Jr. Am. Med. Assoc., 1937, cix, 1176. CrossrefGoogle Scholar3. HOWARDBARKER JEHW: Paroxysmal hypertension and other clinical manifestations associated with benign chromaffin cell tumors, Bull. Johns Hopkins Hosp., 1937, lxi, 371. Google Scholar4. COPESCHATZSKI OR: Tumor of the adrenal glands. I. A modified air injection roentgen technic for demonstrating cortical and medullary tumors, Arch. Int. Med., 1939, lxiv, 1222. CrossrefGoogle Scholar5. YOUNG HH: A technique for simultaneous exposure and operation on the adrenals, Surg., Gynec., and Obst., 1936, lxiii, 178. Google Scholar6. MCCULLAGHENGEL EPWJ: Pheochromocytoma with hypermetabolism, Ann. Surg., 1942, cxvi, 61. CrossrefGoogle Scholar7. LUKENSDOHAN FDFC (a) : Pituitary-diabetes in the cat; recovery following insulin or dietary treatment, Endocrinology, 1942, xxx, 175. (b) LUKENS F. D. W., DOHAN F. C. WOLCOTT M. W.: Pituitary-diabetes in the cat; recovery following phlorizin treatment, Endocrinology, 1943, xxxii, 475. CrossrefGoogle Scholar8. LUKENS FD: Personal communication. Google Scholar9. HERDE M: Zur Lehre der Paragangliome der Nebenniere, Arch. f. klin. Chir., 1912, xcvii, 937. Google Scholar10. HELLY K: Zur Pathologie der Nebenniere, München. med. Wchnschr., 1913, lx, 1811. Google Scholar11. BIEBLWICHSEL MP: Physiologische pathologisch-anatomische Betrachtungen in Anschluss an einen Fall von Paragangliome bei der Nebennieren, Virchow's Arch. f. path. Anat., 1925, cclvii, 182. CrossrefGoogle Scholar12. SCHRÖDER K: Eine doppelseitige chromaffine Nebennierengeschwulst mit Hypertonie, Virchow's Arch. f. path. Anat., 1928, cclxviii, 291. CrossrefGoogle Scholar13. ROGERS E: Paroxysmal hypertension associated with a ganglioneuroma of the suprarenal medulla, Am. Heart Jr., 1932, viii, 269. CrossrefGoogle Scholar14. DE WESSELOW OL: Arterial hypertension, Lancet, 1934, ii, 636. CrossrefGoogle Scholar15. STRICKLER CW: Pheochromocytoma: Operative failure, South. Surgeon, 1942, xi, 193. Google Scholar16. BISKINDMEYERBEADNER GRMASA: Pheochromocytoma cured by surgical intervention. Clinical management. Analysis of all reported operated cases, Jr. Clin. Endocrinol., 1941, i, 113. CrossrefGoogle Scholar17. LOZNERWINKLERTAYLORPETERS ELAWFHJP: The intravenous glucose tolerance test, Jr. Clin. Invest., 1941, xx, 507. CrossrefGoogle Scholar18. THORNKOEPFLEWISOLSEN GWGFRAEF: Carbohydrate metabolism in Addison's disease, Jr. Clin. Invest., 1940, xix, 813. CrossrefGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Baltimore, Maryland*Received for publication December 28, 1943.From the Medical Clinic, the School of Medicine, The Johns Hopkins University and Hospital and The James Buchanan Brady Urological Institute, The Johns Hopkins Hospital. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byPhaeochromocytoma and hepatocellular carcinoma with nuclear glycogenation of the hepatocytes in a predatory carp, Chanodichthys erythropterus (Basilewsky)PHEOCHROMOCYTOMADIABETES MELLITUS OF NONPANCREATIC ORIGINAdrenal cortical carcinoma simulating a phæochromocytomaManagement of PheochromocytomaPhaeochromocytoma removal and postoperative hypoglycaemiaHormonal Diabetes Secondary to Extrapancreatic EndocrinopathiesPhaeochromocytomaHormonal DiabetesChemically and Hormonally Induced DiabetesDie Prognose des DiabetesFamiliär auftretendes Adrenalin produzierendes Phäochromocytom in Kombination mit medullärem Thyreoidea-CarcinomCarbohydrate and Fat Metabolism in Patients with PheochromocytomaCardiovascular SystemGlycosuriaStoria dell'eziologia del diabete mellitoBibliographySome Vagaries of Pheochromocytoma Four Illustrative CasesMILTON A. BELL, M.D., WILLIAM S. BLAKEMORE, M.D., EDWARD ROSE, M.D., F.A.C.P.Die Chirurgie des RetroperitonealraumesUnexplained Remission of Long Standing Severe Diabetes MellitusJAMES J. HINES, M.D., DONALD L. KESSLER, M.D., F.A.C.P.PHEOCHROMOCYTOMA AND DIABETES MELLITUS: REPORT OF A CASE WITH TRANSIENT EXACERBATION OF DIABETIC RETINOPATHY FOLLOWING REMOVAL OF THE TUMOR*JAY A. DESJARDINS, M.D., ROBERT C. BROD, M.D.HypertonieHypertonieHistopathology of pheochromocytomaSevere Diabetes with RemissionHypertension during operation.An Operated Case of Pheochromocytoma with Diabetic SymptomsPHEOCHROMOCYTOMA: THE VALUE OF CERTAIN TESTS USED ROUTINELY IN DIAGNOSIS*EDWARD S. ORGAIN, M.D., F.A.C.P.THE RÔLE OF ACTH, CORTISONE AND HYDROCORTISONE IN SURGERY*†WILLIAM E. ABBOTT, M.D., HARVEY KRIEGER, M.D., STANLEY LEVEY, Ph.D.PHEOCHROMOCYTOMA: TWO CASE REPORTS WITH UNUSUAL REACTIONS AND A GENERAL REVIEW*CHARLIE F. WINGO, M.D., JOHN P. WILLIAMS, M.D., F.A.C.P., FRANK A. WADE, M.D.Die Keimdrüsen und ihre KrankheitenKrankheiten des KohlenhydratstoffwechselsChemical screening methods for the diagnosis of pheochromocytomaThe localization of ph˦ochromocytomasModern concepts of the physiopathology of diabetes mellitusAcromegaly Associated with Phaeochromocytoma.Amelioration of Diabetes and Striking Rarity of Acidosis in Patients with Kimmelstiel-Wilson LesionsPheochromocytomaAdrenal medullary functionPharmacologic and physiologic studies of a case of pheochromocytomaSustained Hypertension due to PheochromocytomaPheochromocytoma with neurofibromatosisThe Differential Diagnosis of PheochromocytomaBenign and Malignant Pheochromocytomas with Necropsies: Benign Case with Multiple Neurofibromatosis and Cavernous Hemangioma of Fourth Ventricle; Malignant Case with Widespread Metastases and Bronchiogenic CarcinomaPheochromocytomaPheochromocytoma with diabetes and hypertensionSome Kinds of Hypertension Which Demand SurgeryPheochromocytomaSurgical Aspects of Bilateral Familial PheochromocytomaPheochromocytomas Coexisting in Adrenal Gland and Retroperitoneal Space, with Sustained HypertensionClinical Problem of Pheochromocytoma 1 May 1944Volume 20, Issue 5Page: 815-821KeywordsCarbohydrate metabolismDiabetes mellitusHospital medicineHypertensionPheochromocytoma Issue Published: 1 May 1944 PDF downloadLoading ...