PRIMARY SPLENIC NEUTROPENIA WITH ARTHRITIS (SO-CALLED FELTY'S SYNDROME). ITS TREATMENT BY SPLENECTOMY
Authors: S SMITH, E S McCABE
Journal: Annals of Internal Medicine (1948)

Article1 September 1948PRIMARY SPLENIC NEUTROPENIA WITH ARTHRITIS (SO-CALLED FELTY'S SYNDROME). ITS TREATMENT BY SPLENECTOMYSOL SMITH, M.D., E. S. MCCABE, M.D.SOL SMITH, M.D.Search for more papers by this author, E. S. MCCABE, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-29-3-445 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptIn 1924 Felty1described the syndrome of chronic rheumatoid arthritis associated with splenomegaly and leukopenia. He was preceded by Still2who, in 1897, reported a disease of children characterized by chronic joint disease, splenomegaly and leukocytosis. In 1932 Hanrahan and Miller3performed the first splenectomy for Felty's syndrome. The operation was done primarily to relieve the patient of the discomforts of the enlarged spleen and to correct the leukopenia. What reasoning led them to expect the latter is obscure. Because of the good result obtained by Hanrahan and Miller, Craven4carried out the same operation in his patient in 1934....Bibliography1. FELTY AR: Chronic arthritis in the adult associated with splenomegaly and leukopenia, Bull. Johns Hopkins Hosp., 1924, xxxv, 16-20. Google Scholar2. STILL GF: On a form of chronic joint disease in children, Med.-Chir. Trans., 1897, lxxx, 47-60. CrossrefGoogle Scholar3. HANRAHANMILLER EMSR: Effect of splenectomy in Felty's syndrome, Jr. Am. Med. Assoc., 1932, xcix, 1247-1249. CrossrefGoogle Scholar4. CRAVEN EB: Splenectomy in chronic arthritis associated with splenomegaly and leucopenia (Felty's syndrome), Jr. Am. Med. Assoc., 1932, cii, 823-826. Google Scholar5. STEINBERG CL: The value of splenectomy in Felty's syndrome, Ann. Int. Med., 1942, xvii, 26-40. Google Scholar6. 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TALKOVBAUERSHORT RHWCL: Rheumatoid arthritis associated with splenomegaly and leucopenia, New Eng. Jr. Med., 1942, ccxxvii, 395-399. CrossrefGoogle Scholar13. DAMESHEK W: Leukopenia and agranulocytosis, 1944, Oxford Loose Leaf Medicine, New York, ii, part 3, 841-848. Google Scholar14. DAMESHEK W: Editorial, Blood, 1946, i, 173-174. CrossrefGoogle Scholar15. DOANWRIGHT CAC: Primary congenital and secondary acquired splenic panhematopenia, Blood, 1946, i, 10-26. CrossrefGoogle Scholar16. WILLIAMS RH: Felty's syndrome, report of a case with necropsy findings, Ann. Int. Med., 1936, ix, 1247-1255. Google Scholar17. LUCIALEONARDFALCONER SPMEEH: The effect of the subcutaneous injection of adrenalin on the leukocyte count of splenectomized patients and of patients with certain diseases of the hematopoietic and lymphatic systems, Am. Jr. Med. Sci., 1937, cxciv, 35-42. CrossrefGoogle Scholar18. ROETTIGNAUSBAUMCURTIS LCWBGM: Traumatic rupture of the spleen, Am. Jr. Surg., 1943, lix, 292-319. CrossrefGoogle Scholar19. DARLINGPARKERJACKSON RCFH: The pathological changes in the bone marrow in agranulocytosis, Am. Jr. Path., 1936, xii, 1-10. Google Scholar20. FITZ-HUGHKRUMBHAAR TEB: Myeloid cell hyperplasia of the bone marrow in agranulocytic angina, Am. Jr. Med. Sci., 1932, clxxxiii, 104-110. CrossrefGoogle Scholar21. ABRAMID'ALLAINESDUGAS PFJ: Du mécanisme de l'anémie au cours des anémies spleniques de l'adulte. Splenomegalies hémolytiques et splenomegalies myelopéniques, La Sang, 1944, xvi, 213-218. Google Scholar22. SALZERRANSOHOFFBLATT MJLH: Primary splenic neutropenia, with report of a case, Ann. Int. Med., 1945, xxii, 271-273. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Baltimore, Maryland*Received for publication November 15, 1946.From the Medical Service, Mercy Hospital, Baltimore, Md., and the Department of Medicine, University of Maryland, Baltimore, Md. 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ROSENBERG, M.D., F.A.C.P., CHARLEY J. SMYTH, M.D.SPLENECTOMY IN RHEUMATOID ARTHRITIS*CHARLES LEROY STEINBERG, B.S., M.D., F.A.C.P.Die pathogenetische Bedeutung der Allergie für Blut- und KnochenmarksschädenDie Panmyelophthise und verwandte Zustände der KnochenmarksinsuffizienzHYPERSPLENISM WITH ARTHRITIS 1 September 1948Volume 29, Issue 3Page: 445-455KeywordsChildrenFelty syndromeHospital medicineLeukocytosisMedical servicesNeutropeniaReasoningRheumatoid arthritisSplenectomySplenomegaly ePublished: 1 December 2008 Issue Published: 1 September 1948 PDF downloadLoading ...