BENZEDRINE AND PAREDRINE IN THE TREATMENT OF ORTHOSTATIC HYPOTENSION, WITH SUPPLEMENTARY CASE REPORT
Authors: Horace Marshall Korns, William Lloyd Randall
Journal: Annals of Internal Medicine (1938)

Case Reports1 August 1938BENZEDRINE AND PAREDRINE IN THE TREATMENT OF ORTHOSTATIC HYPOTENSION, WITH SUPPLEMENTARY CASE REPORTHORACE MARSHALL KORNS, M.D., WILLIAM LLOYD RANDALL, M.D.HORACE MARSHALL KORNS, M.D., WILLIAM LLOYD RANDALL, M.D.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-12-2-253 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptIn January, 1937, in a report1of our experience with benzedrine in the treatment of orthostatic hypotension, we pointed out that if amounts of either benzedrine or ephedrine sufficiently large to maintain the blood pressure within normal limits were employed for more than a few days at a time, it became difficult, even with full doses of the various barbiturates, to overcome the consequent insomnia. When this statement caught the eye of Mr. W. F. Thompson, of the Smith, Kline and French Laboratories, he suggested that we try paredrine (beta-parahydroxyphenylisopropylamine), a related amine, which, according to preliminary pharmacologic studies,2, 3,...References1. KORNSRANDALL HMWL: Orthostatic hypotension treated with benzedrine, Am. Heart Jr., 1937, xiii, 114. CrossrefGoogle Scholar2. ALLES GA: The comparative physiological actions of the dl-beta-phenylisopropylamines. I. Pressor effect and toxicity, Jr. Pharm. and Exper. Therap., 1933, xlvii, 339. Google Scholar3. NATHANSON MH: Action of parahydroxyphenylisopropylamine on induced cardiac standstill, Proc. Soc. Exper. Biol. and Med., 1937, xxxv, 627. CrossrefGoogle Scholar4. ABBOTTHENRY WOCM: Paredrine (beta-4-hydroxyphenylisopropylamine). A clinical investigation of a sympathomimetic drug, Am. Jr. Med. Sci., 1937, cxciii, 661. CrossrefGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Iowa City, Iowa*Received for publication August 26, 1937.From the Department of Internal Medicine, State University of Iowa. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byAmphetaminesÜber außermedizinische Verwendung der Weckamine und das Problem der LeistungssteigerungEffects of Posture on Renal Excretion of Sodium and Chloride in Orthostatic HypotensionParedrine Hydrobromide in Chronic Conjunctivitis*Tolerance of Rats Toward Amphetamine and MethamphetaminORTHOSTATIC HYPOTENSION: REPORT OF A CASE REFRACTORY TO VASOCONSTRICTOR DRUGS; WITH OBSERVATIONS ON USE OF DESOXYCORTICOSTERONE, LNOREPINEPHRINE, ACTH AND VASOPRESSOR POTENTIATING SUBSTANCES*EDWIN A. CROST, M.D., HERZL FRIEDLANDER, M.D.POSTURAL HYPOTENSIONAcute rheumatic heart disease in the aged, with report of a case with Stokes-Adams syndrome treated with paredrineThe treatment of orthostatic hypotensionThe pressor action of paredrine; Further observationsThe cardiovascular effects of paredrineThe Importance of Studying the Postural Responses of the Blood Pressure and the Heart Rate, with a Note on the Method of Taking the Blood Pressure in the Erect Posture 1 August 1938Volume 12, Issue 2Page: 253-255KeywordsBlood pressureHypotensionInsomnia ePublished: 1 December 2008 Issue Published: 1 August 1938 PDF downloadLoading ...