THE SIGNIFICANCE OF BACTERIAL HYPERSENSITIVITY IN HUMAN BRUCELLOSIS: STUDIES ON INFECTION DUE TO STRAIN 19 BRUCELLA ABORTUS
Authors: W W SPINK
Journal: Annals of Internal Medicine (1957)

Article1 November 1957THE SIGNIFICANCE OF BACTERIAL HYPERSENSITIVITY IN HUMAN BRUCELLOSIS: STUDIES ON INFECTION DUE TO STRAIN 19 BRUCELLA ABORTUSWESLEY W. SPINK, M.D., F.A.C.P.WESLEY W. SPINK, M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-47-5-861 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptAlthough the host-parasite relationship in many infectious diseases has been intensively studied in man, it is surprising how little is known about the fundamental mechanisms that are responsible for the resultant human illness. In conjunction with studies on the host-parasite factors in brucellosis, my associates and I have sought an answer to the question, What basic features contribute to the illness of a patient with this disease?The purpose of this report is to point out the significance of bacterial hypersensitivity in the genesis of the illness caused by brucella organisms. Such a thesis has been proposed by others, not...Bibliography1. Gilman HL: Undulant fever caused by Brucella abortus, strain 19, Cornell Vet. 34: 193, 1944. Google Scholar2. SpinkThompson WWH: Human brucellosis caused by Brucella abortus, strain 19, J. A. M. A. 153: 1162, 1953. CrossrefMedlineGoogle Scholar3. Bardenwerper HW: Human sickness caused by Brucella abortus, strain 19, J. A. M. A. 155: 970, 1954. CrossrefMedlineGoogle Scholar4. SaduskBrowneBorn JFASJL: Human brucellosis resulting from Brucella abortus strain 19 vaccine, J. A. M. A. 164: 1325, 1957. CrossrefMedlineGoogle Scholar5. Spink WW: The nature of brucellosis, 1956, University of Minnesota Press, Minneapolis, p. 185. Google Scholar6. Braude AI: Studies in the pathology and pathogenesis of experimental brucellosis. II. The formation of the hepatic granuloma and its evolution, J. Infect. Dis. 89: 87, 1951. CrossrefMedlineGoogle Scholar7. Arias J: Contribucion al conocimiento de la pathologia de la brucelosis, An. Fac. med., Lima 34: 429, 1951. CrossrefGoogle Scholar8. Burnet E: Des reinoculations dans l'infection a M. melitensis, en particulier d'apres la maladie experimentale du cobaye, Arch. Inst. Pasteur de Tunis 14: 62, 1925. Google Scholar9. SpinkBraudeCastanedaGoytia WWAIMRRS: Aureomycin therapy in human brucellosis due to Brucella melitensis , J. A. M. A. 138: 1145, 1948. CrossrefMedlineGoogle Scholar10. SpinkAnderson WWD: Experimental studies on the significance of endotoxin in the pathogenesis of brucellosis, J. Clin. Investigation 33: 540, 1954. CrossrefMedlineGoogle Scholar11. Spink WW: The significance of endotoxin in brucellosis: experimental and clinical studies, Tr. A. Am. Physicians 67: 283, 1954. MedlineGoogle Scholar12. Abernathy R: Sensitivity of human subjects to Brucella endotoxin and its significance in the pathogenesis of brucellosis, J. Lab. and Clin. Med. 48: 780, 1956. Google Scholar13. PiroskyMolinelli IEA: Estudios sobre alergia brucelosa. I. Empleo del complejo glucidolipido de brucella en la investigacion alergica del hombre, Revist. de Med. y Cienc. afines, Buenos Aires 6: 850, 1944. Google Scholar14. Hall WH: The bactericidal action of human blood against Brucella and its specific inhibition, in Third Inter-American Congress on Brucellosis, Washington, D. C., Pan American Sanitary Bureau, 1950, p. 87. Google Scholar15. AbernathySpink RSWW: Protection against Brucella with heterologous endotoxins, J. Clin. Investigation 35: 687, 1956. Google Scholar16. HalbergSpinkBittner FWWJJ: Protection by aldosterone and 11,17-oxycorticoids against effects of Brucella somatic antigen in adrenalectomized mice, Endocrinology 59: 380, 1956. CrossrefMedlineGoogle Scholar17. AbernathyHalbergSpink RSFWW: Studies on the mechanism of chlorpromazine protection against Brucella endotoxin in mice, J. Lab. and Clin. Med. 49: 708, 1957. MedlineGoogle Scholar18. SpinkHall WWWH: The influence of cortisone and adrenocorticotrophic hormone on brucellosis. II. Adrenocorticotrophic hormone (ACTH) in acute and chronic human brucellosis, J. Clin. Investigation 31: 958, 1952. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: WESLEY W. SPINK, M.D., F.A.C.P.Affiliations: Minneapolis, Minnesota*Presented at the Thirty-eighth Annual Session of The American College of Physicians, Boston, Massachusetts, April 11, 1957.From the Department of Medicine, University of Minnesota Hospitals and Medical School.Requests for reprints should be addressed to Wesley W. Spink, M.D., Department of Medicine, University of Minnesota Medical School, Minneapolis 14, Minnesota. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byVeterinary PharmaceuticalsNeedlestick Injuries in Agriculture Workers and Prevention ProgramsBrucellosisBrucellosisAdverse events in humans associated with accidental exposure to the livestock brucellosis vaccine RB51BrucellosisBrucellosisBrucelosis y derrame pleural: Revisión de la literaturaBrucellosisAllergyBRUCELLOSIS AS A HUMAN HEALTH HAZARD IN AUSTRALIAKrankheiten durch BrucellenKrankheiten durch BrucellenHOST-PARASITE RELATIONSHIP IN BRUCELLOSISSection E. Diseases of dairy cattleADRENOCORTICAL STEROIDS IN THE MANAGEMENT OF SELECTED PATIENTS WITH INFECTIOUS DISEASES*WESLEY W. SPINK, M.D., F.A.C.P. 1 November 1957Volume 47, Issue 5 Page: 861-874 Keywords Antigens Brucella Brucellosis Hospital medicine Hypersensitivity Infectious diseases ePublished: 1 December 2008 Issue Published: 1 November 1957 PDF downloadLoading ...