HOST FACTORS IN POLYCYTHEMIA VERA
Authors: A DAMON, D A HOLUB
Journal: Annals of Internal Medicine (1958)

Article1 July 1958HOST FACTORS IN POLYCYTHEMIA VERAALBERT DAMON, M.D., Ph.D., DONALD A. HOLUB, M.D.ALBERT DAMON, M.D., Ph.D.Search for more papers by this author, DONALD A. HOLUB, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-49-1-43 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe occurrence of polycythemia vera predominantly in middle life is well documented. Males seem to be affected more frequently than females, but to an extent that varies widely from one reported series to another. The clinical impression is strong, as quoted in current texts,1-3that Negroes are rarely affected and Jews relatively often, but published evidence leaves much to be desired. That for Negroes rests on a single series in 1924, in which one of 34 patients was a Negro! The statistical basis for the presumed high incidence among Jews consists of Türk's5five Jewish patients of seven with polycythemia...Bibliography1. Wintrobe MM: Clinical hematology, 4th Ed., 1956, Lea and Febiger, Philadelphia. Google Scholar2. Sturgis CC: Hematology, 2nd Ed., 1955, Charles C Thomas, Springfield, Illinois. Google Scholar3. WhitbyBritton LECJ: Disorders of the blood, 7th Ed., 1953, Grune and Stratton, New York. Google Scholar4. Futcher TB: The clinical aspects of erythremia, Boston M. and S. J. 191: 304, 1924. CrossrefGoogle Scholar5. Türk W: Beiträge zur Kenntnis des Symptomen-Bildnis: Polycythämie mit Milztumor und "Zyanose," Wien. klin. Wchnschr. 6: 153, 189, 1904. Google Scholar6. Lucas WS: Erythremia or polycythemia with chronic cyanosis and splenomegaly, Arch. Int. Med. 10: 597, 1912. CrossrefGoogle Scholar7. ReznikoffFootBethea PMCJM: Etiologic and pathologic factors in polycythemia vera, Am. J. M. Sc. 189: 753, 1935. CrossrefGoogle Scholar8. Videbaek A: Polycythemia vera. Course and prognosis, Acta med. Scandinav. 138: 179, 1950. CrossrefMedlineGoogle Scholar9. Lawrence JH: Polycythemia, 1955, Grune and Stratton, New York. Google Scholar10. MacMahonKoller BEK (a) : Ethnic differences in the incidence of leukemia, Blood 12: 1, 1957. (b) Damon, A., Holub, D. A., Melicow, M. M., and Uson, A. C.: Polycythemia and renal carcinoma: report of 10 new cases, two with long hematologic remission following nephrectomy, Am. J. Med., in press. CrossrefMedlineGoogle Scholar11. Peacock HA: Blood pressure and blood volume in cases of polycythemia vera, Proc. Staff Meet., Mayo Clin. 4: 286, 1929. Google Scholar12. Hall BE: Therapeutic use of radiophosphorus in polycythemia vera, leukemia and allied diseases. Symposium on the use of isotopes in biology and medicine, 1948, University of Wisconsin Press, Madison, Wisconsin. Google Scholar13. Sohval AR: Hepatic complications in polycythemia vera, Arch. Int. Med. 62: 925, 1938. CrossrefGoogle Scholar14. RosenthalRosenthal NRL: Treatment of polycythemia vera with triethylene melamine, Arch. Int. Med. 90: 379, 1952. CrossrefGoogle Scholar15. FauvertMallarméNicollo RJS: La maladie de Vaquez et son traitement par le phosphore radio-actif (P32), Semaine d. hôp., Paris 30: 42, 1954. MedlineGoogle Scholar16. TubianaGazel MJ: Action du phosphore radioactif sur la polyglobulie essentielle et l'augmentation du nombre des plaquettes, Presse méd. 63: 851, 1955. MedlineGoogle Scholar17. Mainland D (a) : Elementary medical statistics, 1952, W. B. Saunders Company, Philadelphia, pp. 142-143. (b) Croce, Dr. Joseph, New York City: Personal communication. Google Scholar18. NadlerCohn SBI: Familial polycythemia, Am. J. M. Sc. 198: 41, 1939. CrossrefGoogle Scholar19. Torup E: To tilfaelder af polycythaemia vera hos børn, to brødre, Ugesk. f. læger 117: 44, 1955. MedlineGoogle Scholar20. Hottinger A: Beiträge zur Kenntnis der kindlichen Polycythämie, Ztschr. f. Kinderh. 44: 61, 1927. CrossrefGoogle Scholar21. Halbertsma T: Polycythemia in childhood, Am. J. Dis. Child. 46: 1356, 1933. CrossrefGoogle Scholar22. Erf LA: Radioactive phosphorus in the treatment of primary polycythemia (vera), in Progress in hematology, L. M. Tocantins, Editor, 1956, Vol. 1, Grune & Stratton, New York, p. 153. Google Scholar23. ScudderOsborne JRH: Personal communication. Google Scholar24. Osler W: Chronic cyanosis with polycythemia and enlarged spleen: a new clinical entity, Am. J. M. Sc. 126: 187, 1903. CrossrefGoogle Scholar25. DameshekHenstell WHH: The diagnosis of polycythemia, Ann. Int. Med. 13: 1360, 1940. LinkGoogle Scholar26. Blake D: Unpublished student thesis, Harvard Medical School, 1937. Google Scholar27. Reznikoff P: Polycythemia, in Symposium on the blood, 1939, University of Wisconsin Press, Madison, Wisconsin. Google Scholar28. Fraenkel R: Personal communication, June 24, 1957. Google Scholar29. Laidlaw W: Population of the City of New York, 1890-1930, 1932, Cities Census Committee, New York. CrossrefGoogle Scholar30. WeberBode FPOB: Polycythemia, erythrocytosis, and erythremia, 1929, H. K. Lewis, London. Google Scholar31. Zadek I: Die Polycythämien, Ergebn. d. ges. Med. 10: 355, 1927. Google Scholar32. Harrop GA: Polycythemia, Medicine 7: 291, 1928. Google Scholar33. Hirvonen M: Klinische Untersuchungen über die Polyzythämie, Acta med. Scandinav. 120: 568, 1945. CrossrefGoogle Scholar34. PettOgilvie LBGF: The Canadian weight-height survey, Human Biol. 28: 67, 1956. MedlineGoogle Scholar35. Brachetto-BrianMoguilevskyGrinbergItre DLRH: La edad de la menarca menopausia y duracion de la vida menstrual en las mujeres con cancer de mama, Prensa med. argent. 38: 236, 1951. MedlineGoogle Scholar36. AndersonReedHusebyOliver ESCRACP: Possible relationship between menopause and age at onset of breast cancer, Cancer 3: 410, 1950. CrossrefMedlineGoogle Scholar37. CorscadenGusberg JASB: The background of cancer of the corpus, Am. J. Obst. and Gynec. 53: 419, 1947. CrossrefMedlineGoogle Scholar38. Rendelstein FD: Spätmenarche und Uteruskarzinom, Krebsarzt 3: 347, 1948. MedlineGoogle Scholar39. EpsteinBoasSimpson FHEPR: The epidemiology of atherosclerosis among a random sample of clothing workers of different ethnic origins in New York City, J. Chron. Dis. 5: 300, 1957. CrossrefMedlineGoogle Scholar40. Rawson RW: Today's thyroidologists and their beckoning frontiers, J. Clin. Endocrinol. 16: 1405, 1956. CrossrefGoogle Scholar41. GutmanYüWeissman ABTFB: The concept of secondary gout; relation to purine metabolism in polycythemia and myeloid metaplasia, Tr. A. Am. Physicians 69: 229, 1956. MedlineGoogle Scholar42. HolmesKredelHanna CRFECB: Polycythemia secondary to brain tumor, South. M. J. 45: 967, 1952. CrossrefMedlineGoogle Scholar43. SchmidFrench RLA: Cerebellares Hemangioblastom mit Polycythämie, Schweiz. med. Wchnschr. 85: 1274, 1955. MedlineGoogle Scholar44. WardFoltzKnopp AAELLM: "Polycythemia" associated with cerebellar hemangioblastoma, J. Neurosurg. 13: 248, 1956. CrossrefMedlineGoogle Scholar45. StroebelFowler CFWS: Secondary polycythemia, M. Clin. North America 40: 1061, 1956. CrossrefMedlineGoogle Scholar46. Tumen HJ: The association of polycythemia with occlusion of the inferior vena cava: report of a case, Am. J. Obst. and Gynec. 20: 417, 1930. CrossrefGoogle Scholar47. ThomsonMarson APFG: Polycythemia with fibroids, Lancet 1: 759, 1953. CrossrefGoogle Scholar48. EngelSinger HWK: Polycythemia with fibroids, J. A. M. A. 159: 190, 1955. CrossrefMedlineGoogle Scholar49. HorwitzMcKelway AWP: Polycythemia associated with uterine myomas, J. A. M. A. 158: 1361, 1955. MedlineGoogle Scholar50. Singmaster L: Uterine fibroids associated with polycythemia, J. A. M. A. 163: 36, 1957. CrossrefMedlineGoogle Scholar51. Forssell J: Polycythemia and hypernephroma, Acta med. Scandinav. 150: 155, 1954. CrossrefGoogle Scholar52. Moe E: Polycytaemi og hypernefrom, Nord. med. 56: 1164, 1956. MedlineGoogle Scholar53. BergerSinkoff LMW: Systemic manifestations of hypernephroma, Am. J. Med. 22: 791, 1957. CrossrefMedlineGoogle Scholar54. TinneyHallGiffin WSBEHZ: Polycythemia vera and peptic ulcer, Proc. Staff Meet., Mayo Clin. 18: 24, 1943, et seq. Google Scholar55. StroebelLaw CFWM: Polycythemia vera, M. Clin. North America 40: 1045, 1956. CrossrefMedlineGoogle Scholar56. BrownGiffin GEHZ: Peripheral arterial disease in polycythemia vera, Arch. Int. Med. 46: 705, 1930. CrossrefGoogle Scholar57. NormanAllen ILEV: The vascular complications of polycythemia, Am. Heart J. 13: 257, 1937. CrossrefGoogle Scholar58. MasouredisLawrence SPJH: The problem of leukemia in polycythemia vera, Am. J. M. Sc. 233: 268, 1957. CrossrefMedlineGoogle Scholar59. CramerKimsey FW: The cerebellar hemangioblastomas. Review of 53 cases with special reference to cerebellar cysts and the association of polycythemia, Arch. Neurol. and Psychiat. 67: 237, 1952. CrossrefGoogle Scholar60. Bliss TL (a) : Basal metabolism in polycythemia vera, Ann. Int. Med. 2: 1155, 1929. (b) Medvei, C. V.: Über ein bemerkenswertes Zusammentreffen von Arthritis urica, Erythrämie Typ Vaquez und Hypernephroma malignum, Wien. Arch. f. inn. Med. 24: 417, 1934. (c) Fairley, K. D.: Two cases of Gaisböck's disease (polycythemia hypertonica) associated with carcinoma of the kidney, Roy. Melbourne Hosp. Clin. Rep. 16: 47, 1945. LinkGoogle Scholar61. Chwalla R (a) : Endokrine Erscheinungen beim Hypernephrom der Niere und ihre Bedeutung, Ztschr. f. Urol. 45: 521, 1952. (b) Herbeuval, R., Cuny, G., and Larcan, A.: Maladie de Vaquez et hypernéphrome, Presse méd. 65: 132, 1957. Google Scholar62. Forssell J: Polycytemi vid hypernefrom, Nord. med. 30: 1415, 1946. Google Scholar63. MelicowUson MMA: Personal communication. Google Scholar64. Kurrle GR (a) : A case of Gaisböck's disease, M. J. Australia 41: 777, 1954. (b) De Marsh, Q. B., and Warmington, W. J.: Polycythemia associated with a renal tumor, Northwest Med. 54: 976, 1955. (c) Cooper, W. M., and Tuttle, W. B.: Polycythemia associated with a benign kidney lesion: report of a case of erythrocytosis with hydronephrosis, with remission of polycythemia following nephrectomy, Ann. Int. Med. 47: 1008, 1957. CrossrefMedlineGoogle Scholar65. JacobsonGoldwasserFriedPlzak LOEWL: Role of the kidney in erythropoiesis, Nature 179: 633, 1957. CrossrefMedlineGoogle Scholar66. FitzpatrickSchwartz WJSO: Polycythemia secondary to tuberculosis of the spleen, Am. Rev. Tuberc. 60: 660, 1949. MedlineGoogle Scholar67. EllmanFairburn PAC: Polycythemia vera in chronic pulmonary tuberculosis, Brit. J. Tuberc. 47: 107, 1953. Google Scholar68. Bockus HL: Gastro-enterology, Vol. 3, 1946, W. B. Saunders Company, Philadelphia, p. 594. Google Scholar69. RandallEimanLeberman AJEPR: Studies on the pathology of the renal papilla, J. A. M. A. 109: 1698, 1937. CrossrefGoogle Scholar70. Rosenow EC: Renal calculi: a study of papillary calcification, J. Urol. 44: 19, 1940. CrossrefGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: *Received for publication August 30, 1957.From the Department of Medicine, College of Physicians and Surgeons, Columbia University, and the Presbyterian Hospital, New York, New York.†This work was done during the tenure of a Research Fellowship of the American Heart Association (Dr. Damon).‡Fellow of the National Foundation for Infantile Paralysis.Requests for reprints should be addressed to Albert Damon, M.D., Department of Industrial Hygiene, Harvard School of Public Health, 1 Shattuck Street, Boston 15, Massachusetts. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byMore Than a Myoma: A Review of Myomatous Erythrocytosis SyndromeThe Pathogenesis, Diagnosis, and Treatment of Polycythaemia VeraPolycythemia Vera: A Comprehensive Review and Clinical RecommendationsSekundäre Hyperurikämie und GichtExcess of Blood Group B in Primary MyelofibrosisHuman physique and susceptibility to noninfectious diseaseHost factors in “chromophobe” adenoma of the anterior pituitary: A retrospective study of 464 patientsSecondary gout associated with chronic myeloproliferative disordersAberrant hormone activity by tumors of gynecologic importanceAlbert Damon (1918–1973)The Association of Erythrocytosis and LymphomaPolyglobulie und Polycythaemia veraPLATELET ADHESIVENESS IN POLYCYTHAEMIA RUBRA VERAErythraemia in Experimental NephritisPOLYCYTHAEMIA ASSOCIATED WITH LEIOMYOMA OF THE UTERUSCEREBELLAR HÆMANGIOBLASTOMA: A MISNOMERPolycythemiaSome host factors in disease: Sex, race, ethnic group, and body formPrimary erythrocytosisExperimentelle Untersuchungen zur Regulation der Erythropoiese unter besonderer Berücksichtigung der Bedeutung des SauerstoffsHydronephrosis and polycythemiaPolycythemia (erythrocytosis) associated with uterine fibroids and apparent surgical curePolycythemiaErythrocythemiaPolycythaemia veraThe association of polycythemia with a cerebellar hemangioblastomaStudies of Purine Metabolism in Neoplastic DiseasesGastric pepsin secretion and ABO blood groups in polycythemia veraCase 45242Polycythæmia 1 July 1958Volume 49, Issue 1Page: 43-60KeywordsHospital medicineJewish peopleMenarcheMenopausePeptic ulcersPoliomyelitisPolycythemiaPolycythemia veraSurgeonsThrombosis ePublished: 1 December 2008 Issue Published: 1 July 1958 PDF downloadLoading ...