RECURRENT PNEUMONIA IN MULTIPLE MYELOMA AND SOME OBSERVATIONS ON IMMUNOLOGIC RESPONSE
Authors: H H ZINNEMAN, W H HALL
Journal: Annals of Internal Medicine (1954)

Article1 December 1954RECURRENT PNEUMONIA IN MULTIPLE MYELOMA AND SOME OBSERVATIONS ON IMMUNOLOGIC RESPONSEHORACE H. ZINNEMAN, M.D., WENDELL H. HALL, M.D.HORACE H. ZINNEMAN, M.D.Search for more papers by this author, WENDELL H. HALL, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-41-6-1152 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptOver a period of several years, many patients with multiple myeloma and recurrent episodes of bacterial pneumonia have been observed at the University of Minnesota and the Minneapolis Veterans Administration Hospitals. However, the literature on multiple myeloma does not emphasize pulmonary infiltrates or recurrent pneumonia except as terminal events.1-6† For this reason it appeared desirable to gather evidence concerning bacterial pneumonia in myelomatosis and to investigate the immunologic response of patients with the disease.MATERIALS AND METHODSThe hospital records of 64 patients with multiple myeloma, observed at the University of Minnesota Hospitals from 1943 to 1953 and at the...Bibliography1. Oftedahl S: Multiple myeloma, J. A. M. A. 77: 1547, 1921. CrossrefGoogle Scholar2. Hansen OS: Multiple myeloma, J. A. M. A. 79: 2059, 1922. CrossrefGoogle Scholar3. GeschickterCopeland CFMM: Multiple myeloma, Arch. Surg. 16: 807, 1928. CrossrefGoogle Scholar4. LichtensteinJaffé LHL: Multiple myeloma, Arch. Path. 44: 207, 1947. Google Scholar5. AdamsAllingLawrence WSELJS: Multiple myeloma, Am. J. Med. 6: 141, 1949. CrossrefMedlineGoogle Scholar6. ChurgGordon JAJ: Multiple myeloma. 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Author, Article, and Disclosure InformationAffiliations: Minneapolis, Minnesota*Presented (in part) at the Minnesota Society of Internal Medicine, Minneapolis, Minnesota, May 23, 1953, and at the Thirty-fifth Annual Session of the American College of Physicians, Chicago, Illinois, April 8, 1954.From the Veterans Administration Hospital and the Department of Medicine, University of Minnesota Medical School.†Recently recurrent pneumonia has been reported in 13 of 97 myelomatous patients by Snapper et al.33 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byArmored BCMA CAR T Cells Eliminate Multiple Myeloma and Are Resistant to the Suppressive Effects of TGF-βInfections in Patients with Leukemia and LymphomaImmune dysfunction in multiple myelomaComplications and Special Presentations of Plasma Cell MyelomaImmunology and Immunotherapeutic Approaches in Multiple MyelomaMultiple myeloma presenting with an acute bacterial infectionAutologous antitumor activity by NK cells expanded from myeloma patients using GMP-compliant componentsImmune TherapiesImmunotherapeutic Strategies for the Management of Multiple MyelomaImmunodeficiency and immunotherapy in multiple myelomaSplenectomy in plasma cell dyscrasias: A review of the clinical practiceActive immunotherapy of multiple myelomaRenal, hematologic and infectious complications in multiple myelomaImmunotherapy in multiple myeloma - possibility or probability?Either interleukin-12 or interferon-γ can correct the dendritic cell defect induced by transforming growth factor β1 in patients with myelomaDendritic cells from patients with myeloma are numerically normal but functionally defective as they fail to up-regulate CD80 (B7-1) expression after huCD40LT stimulation because of inhibition by transforming growth factor-β1 and interleukin-10RT-PCR Amplicons in the Plasma of Multiple Myeloma Patients - Clinical Relevance and Molecular PathologyB-CELL AND IMMUNOGLOBULIN IMMUNODEFICIENCY IN THE ELDERLYComplement Abnormalities in Multiple MyelomaComparative Analysis of Immunodeficiency in Patients with Monoclonal Gammopathy of Undetermined Significance and Patients with Untreated Multiple MyelomaChemiluminescence response of polymorphonuclear leucocytes to serum-opsonized zymosan-a predictive parameter for infections and prognosis in multiple myeloma patientsThe management of myelomatosisAnalysis of immunodeficiency in multiple myeloma: Observations and hypothesisMultiple myeloma: Light chain isotype suppression-A marker of stable disease at presentationHumoral immune deficiency in multiple myeloma patients due to compromised B-cell functionImpaired chemiluminescence response by neutrophils in patients with multiple myelomaImpaired immunoglobulin synthesis in multiple myeloma: A B-cell dysfunctionB-cell activation in human plasma cell dyscrasiasMultiple MyelomaPneumococcal InfectionsCurrent Patterns of Bacterial Infection in MyelomatosisT-cell imbalances in patients with multiple myeloma: An analysis by monoclonal antibodiesAntibody Response to Pneumococcal Vaccination in Patients with MyelomatosisPneumococcal Vaccine: Clinical Efficacy and EffectivenessJ. SANFORD SCHWARTZ, M.D.Immunoregulatory Circuits in MyelomaDiseases associated with immunosuppression.Biphasic Pattern of Bacterial Infection in Multiple MyelomaDAVID G. SAVAGE, M.D., JOHN LINDENBAUM, M.D., T. J. GARRETT, M.D.LiteraturverzeichnisPolyvalent pneumococcal immunization of patients with plasma cell dyscrasiasPneumococcal vaccination: The response of patients with multiple myelomaCharacteristics of Multiple Myeloma as an Immunodeficiency DiseaseAntibody response to infection in multiple myelomaIn vitro stimulation with mitogen and antigen in patients with monoclonal gammopathyImmunodeficiency States Associated with Acute Leukemias, Multiple Myeloma, and Waldenström’s MacroglobulinemiaBiology, Clinical Patterns, and Treatment of Multiple Myeloma and Related Plasma–Cell DyscrasiasPrognostic Factors and Treatment of Multiple Myeloma: Interest of a Cyclic Sequential Chemohormonotherapy Combining Cyclophosphamide, Melphalan, and PrednisonePulmonary InfectionsImmunosuppression and the Role of Suppressive Factors in CancerImmune Response in Asymptomatic ParaproteinemiaChanges in Lymphocyte Surface Immunoglobulins in Myeloma and the Effect of an RNA-Containing Plasma FactorY. CHEN, M.D., Ph.D., N. BHOOPALAM, M.D., V. YAKULIS, B.S., P. HELLER, M.D., F.A.C.P.Multiple myeloma in a patient with sickle cell anemiaPneumococcal erysipelasPossible pathogenetic role of capsular antigens in fulminant pneumococcal disease with disseminated intravascular coagulation (DIC)IMPAIRED IMMUNORESPONSIVENESS IN TUMOR PATIENTSParaproteinämische HämoblastosenImmune Deficiency States Associated with Malignant Disease in ManSeptic arthritis, gout, pseudogout and osteoarthritis in the knee of a patient with multiple myelomaImmunodeficiency Diseases of Man**Original work has been aided by grants from The National Foundation–March of Dimes, U. S. Public Health Service (HE-06314, AI-08677, AI-00798, and NS-02042), and the American Heart Association.The Immunological Deficiency DiseasesErythromycin-resistant pneumococcal osteomyelitisImmunoglobulin Abnormalities in ManBone marrow embolism in multiple myelomaWiskott-Aldrich syndromeRole of Gamma Globulin for Immunoprophylaxis in Multiple MyelomaCurrent Therapy of Bacterial PneumoniasImmunological Deficiency Diseases of Man — Relationships to Disturbances of Germinal Center FormationThe Treatment of Plasma Cell MyelomaTHE ROLE OF THE THYMUS AND BURSA OF FABRICIUS IN THE DEVELOPMENT OF EFFECTOR MECHANISMS*Paraproteinemia in the lymphomasFamilial xanthomatosis and hyperlipidemia, and myelomatosisRestoration of Gamma Globulin Production in Agammaglobulinemic ChickensREFERENCESAntibody Deficiency in ParaproteinemiaErrors and Hazards in the Diagnosis and Treatment of Bacterial PneumoniasJONAS A. SHULMAN, M.D., LEON A. PHILLIPS, M.D., ROBERT G. PETERSDORF, M.D., F.A.C.P.Multiple Myeloma Presenting as Pulmonary Infiltration: Report of a CaseQualitative and quantitative immunoglobulin deficiencyHeavy chain disease—A new disorder of serum γ-globulinsProduction of Antibodies against Viruses in Leukaemia and Related DiseasesB12 Lack (“Pernicious Anaemia”), Possibly Caused by “Parasitization” (Consumption by a Neoplasm), in a Case of Waldenström's MacroglobulinaemiaInfection, antibody response and gamma globulin components in multiple myeloma and macroglobulinemiaInfections, fever and host resistance in neoplastic diseasesSerum protein disorders causing clinical symptoms in malignant neoplastic diseasePatterns of Immunological Deficiency in Lymphomas and LeukemiasDANIEL G. MILLER, M.D.Antibodies to Blood Group A and B Substances in ReticulosesMyeloma and Pernicious AnaemiaThe Significance of Fever in Neoplastic DiseaseANN A. BROWDER, M.D., JOHN W. HUFF, M.D., ROBERT G. PETERSDORF, M.D.CIRCULATING ANTIBODIES IN RETICULOSESGammaglobulin Treatment And Protection Against InfectionsMultiple myelomaHOST-PARASITE RELATIONSHIPS IN PATIENTS WITH DYSPROTEINEMIASHypogammaglobulinaemia in MyelomaAbnormal Serum GlobulinsPlasma-Cell MyelomaThe serum proteins in health and diseaseA Histopathological Study on Multiple Myeloma (Plasmocytoma) and its Relation to Macroglobulinemia Waldenström"MYELOMA" SERUM ELECTROPHORETIC PATTERNS IN CONDITIONS OTHER THAN MYELOMATOSISMultiple myeloma with renal failureThe Gamma Globulins and Their Clinical SignificanceRecent studies on pathophysiologic mechanisms in human neoplastic diseaseMACROGLOBULINEMIA: REPORT OF TWO CASES*HARRY GLENCHUR, M.D., HORACE H. ZINNEMAN, M.D., F.A.C.P., DAVID R. BRIGGS, Ph.D.DysproteinemiaDie MakroglobulinämieThe agammaglobulinemiasMultiple myelomaThe Gamma GlobulinsMACROGLOBULINAEMIAThe Clinical Problem of AgammaglobulinemiaCryo- and macroglobulinemiaCase 42051Chest Disease in Patients with Agammaglobulinemia 1 December 1954Volume 41, Issue 6Page: 1152-1163KeywordsBacterial diseasesBacterial pneumoniaHospital medicineMultiple myelomaPneumoniaPulmonary diseases ePublished: 1 December 2008 Issue Published: 1 December 1954 PDF downloadLoading ...