ACQUIRED SENSITIVITY TO HUMAN ALBUMIN FOLLOWING ALBUMIN TREATMENT OF IDIOPATHIC HYPOPROTEINEMIA
Authors: T C HALL, V DI RAIMONDO
Journal: Annals of Internal Medicine (1954)

Case Reports1 May 1954ACQUIRED SENSITIVITY TO HUMAN ALBUMIN FOLLOWING ALBUMIN TREATMENT OF IDIOPATHIC HYPOPROTEINEMIATHOMAS C. HALL, M.D., VINCENT DI RAIMONDO, M.D.THOMAS C. HALL, M.D.Search for more papers by this author, VINCENT DI RAIMONDO, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-40-5-1017 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptSince concentrated human serum albumin has become available, it has been used extensively as ideal for parenteral protein replacement, and as a plasma volume expander.1It is estimated2that to date, 2,300,000 units of 25 gm. each have been prepared in the United States according to the method of Cohn and his associates.3Although "anaphylactoid,"4pyrogenic and hemodynamic5reactions have been noted to follow intravenous injections of human serum albumin, none due to natural or acquired sensitivity has been reported. Hence the development of sensitivity after repeated administration of albumin, with the appearance of precipitins in the serum of a...Bibliography1. Janeway CA: Clinical use of products of human plasma fractionation, J. A. M. A. 126: 674-680, 1944. CrossrefGoogle Scholar2. Mulford DJ From information obtained from the Commission on Plasma Fractionation and Related Processes and from : Derivatives of blood plasma, Ann. Rev. Physiol. 9: 329-356, 1947. CrossrefGoogle Scholar3. CohnShongHughesMulfordAshworthMelinTaylor EJLEWLDJJNMHL: Preparation and properties of serum and plasma proteins, IV, J. Am. Chem. Soc. 68: 459-475, 1946. CrossrefMedlineGoogle Scholar4. Armstrong SH: Mechanisms of action of serum albumin in therapy in internal medicine, Am. J. Med. 4: 390-397, 1948. CrossrefMedlineGoogle Scholar5. Janeway CA: Plasma fractionation, Advances Int. Med. 3: 295-372, 1949. Google Scholar6. Plasma Proteins, Symposium on Nutrition of the Robert Gould Research Foundation, Volume II, 1950, C. C. Thomas, Springfield, Illinois. Google Scholar7. CohnGurdSurgenorBarnesBrownDerouauxGillespieKahntLeverLiuMittlemanMoutonSchmidUroma EJFRDMBARKGJMFWWFCHDRFKE: A system for the separation of the components of human blood: quantitative procedures for the separation of the protein components of human plasma, J. Am. Chem. Soc. 72: 465-474, 1950. CrossrefGoogle Scholar8. CohnSurgenorTullisBatchelor EJDMJLWH: The biochemistry and biomechanics of the characterization, preservation and analysis of human blood and other tissues, Academic Press, New York (to be published). Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: San Francisco, California*Received for publication August 19, 1953.From the Medical Clinic of the Peter Bent Brigham Hospital and from the Medical Laboratories of the Collis P. Huntington Memorial Hospital of Harvard University at the Massachusetts General Hospital, Boston.This is publication No. 818 of the Cancer Commission of Harvard University. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byHypoalbuminemia (with anasarca) due to hypercatabolism, serum protein exudation into the gastrointestinal tract, increased capillary permeability and hypoanabolism 1 May 1954Volume 40, Issue 5Page: 1017-1023KeywordsAlbuminsHospitalsHypoproteinemiaIntravenous injectionsPlasma proteinsPlasma volumeSerum albuminSerum proteins ePublished: 1 December 2008 Issue Published: 1 May 1954 PDF downloadLoading ...