tbuckley/cabot-search huggingface dataset:
Donor age intensifies the early immune response after transplantation
Authors: A. Reutzel-Selke, A. Jurisch, C. Denecke, A. Pascher, P.N.A. Martins, H. Keßler, A. Tamura, N. Utku, J. Pratschke, P. Neuhaus, S.-G. Tullius
Journal: Kidney International (2007)
The politics of inadequate registers.
Authors: M. White, R. Bhopal
Journal: BMJ (1989)

The questions raised by Dr Cruickshank con- cern achieved blood pressure in individual patients.We obtained a stable reduction in diastolic blood pressure to below 90 mm Hg (treatment target) in 30 of the 41 patients receiving antihypertensive treatment.The following patients had a diastolic blood pressure >90 mm Hg: five of the nine patients with uraemia; two of three patients with myocardial infarction; and four of the 27 patients who survived.These figures indicate that seven of 14 patients who died durirr the studv had a sustained raised blood pressure despite antihypertensive treatment.
Somatostatin Imaging of Neuroendocrine-Differentiated Prostate Cancer
Authors: Thomas A. Hope, Rahul Aggarwal, Jeff P. Simko, Henry F. VanBrocklin, Charles J. Ryan
Journal: Clinical Nuclear Medicine (2015)

After prolonged androgen deprivation therapy, a subset of castrate-resistant prostate cancer patients will develop neuroendocrine prostate cancer (NEPC) associated with resistance to further hormonal therapy and frequent visceral metastases. Imaging the presence of somatostatin receptors on the cancer cell surface may provide a readily available, noninvasive means to distinguish adenocarcinoma from NEPC. This distinction is important for therapeutic decision making and may open the door for developing novel radionuclide targets for the treatment of this aggressive subtype of prostate cancer. We describe a case of NEPC successfully imaged using In-labeled octreotide.
Meso-colic Hernia
Authors: T. B. Peacock
Journal: BMJ (1849)

SYSTEMATIC writers, in enumerating the various causes of internal stran- gulation, usually refer to epiploic, mesenteric, and meso-colic Hernise.The cases, however, which have been described under these names, bave consisted most generally of strangulations of portions of the in- testine through apertures in the epiploon, mesentery, or meso-colon.Of affections of this description, a considerable number are on re- cord.Among these may be mentioned-I.The case related by De Haen,I and made the subject of a graduation thesis by Knobloch, in wbich a por- tion of ileum was strangulated in an aperture in the meso-colon of the sigmoid flexure.2. The case of Saucerote,3 in which portions of the cmcum and colon had passed through an aperture in the mesentery. 3. The instance related by Monro,4 as having occurred to Dr. Rutherford, in which a portion of ileum was strangulated in an opening of the me.sentery.4.An example of internal Hernia, described by Rokitansky,6 in which the cecum was pushed from behind through an aperture in the mesentery of the lower part of the ileum. 5.A case referred to by Grosse,'6 as published by Dr. Davis, in which a portion of colon was strangulated in an opening in the meso-colon of the sigmoid flexure.6.The case recorded by Mr. Ranking,7 in which, part of the ileum having been torn from its mesenteric attachment, a loop of intestine became strangulated in the opening so produced. 7.That related by Dr. Hutton," in which a portion of the small intestine was strangulated in an opening on the mesentery; and lastly, a similar case described by Mr. Phillips.9To these instances may be added one, probably of the same kind, related by SchroederVan der Kolk,'0 and it would not be dif- ficult to collect others.The cases referred to by Baudelocque,'1 Callisen,' Arnaud," and Scarpa, 1 in which loops of intestines were strangulated through apertures in portions of ekiploon or mesentery contained in hernial sacs, are also analogous."Displacements of this description, in which the intestines are not protruded from the abdominal cavity, cannot, however, properly be re- 1 Ratio Medendi, tom.
Down-regulation of hepcidin resulting from long-term treatment with an anti–IL-6 receptor antibody (tocilizumab) improves anemia of inflammation in multicentric Castleman disease
Authors: Soken-Nakazawa J. Song, Naohisa Tomosugi, Hiroshi Kawabata, Takayuki Ishikawa, Teppei Nishikawa, Kazuyuki Yoshizaki
Journal: Blood (2010)
No trust will get foundation status until it has gone through CQC inspection regime, Monitor says
Authors: C. Dyer
Journal: BMJ (2013)

Monitor, the health sector regulator, has announced that it will not grant foundation trust status to any further NHS trusts “until it receives robust assurance from the Care Quality Commission that applicants are providing a good quality of care for patients.”

The decision means that no more foundation trusts will be created until applicants for the status have gone …
Markers of Impaired Growth of Pulmonary Function in Children and Adolescents
Authors: CHARLOTTE SUPPLI ULRIK, VIBEKE BACKER
Journal: American Journal of Respiratory and Critical Care Medicine (1999)

Our knowledge about the age-related growth of pulmonary function is incomplete. The purpose of this study was to describe the relation of various factors to the growth of pulmonary function in children and adolescents. A population sample comprising 408 children and adolescents (7–17 yr of age at enrollment) was reexamined after a 6-yr interval. Case history was obtained by interview and questionnaire. Pulmonary function, skin prick test reactivity to common allergens, and airway responsiveness (AR) were measured using standard techniques; airway hyperresponsiveness (AHR) was defined as a concentration of histamine causing a 20% decline in FEV1 < 8 mg/ml. The cross-sectional analyses of data from the two surveys showed that the presence of asthma (p < 0.02), atopy to house dust mite (HDM) (p = 0.03), and increasing degree of AR (p < 0.002) were associated with a lower level of FEV1 %pred. The longitudinal analysis revealed that asthma (p = 0.0001) and a lower level of FEV1 (p < 0.0001) at enrollment were associated with a lower level of FEV1 at follow-up. Further, an increase in the degree of AR (p = 0.0001), new asthma (p = 0.0002), and new atopy to HDM (p = 0.03) also predicted a lower level of FEV1 at the end of the observation period. Confining the analysis to subjects without asthma and without evidence of AHR (n = 271) showed that both persistent (p = 0.04) and new (p = 0.03) atopy to HDM predicted a lower level of FEV1 at follow-up; compared with subjects with a negative skin reaction to HDM, those subjects who were sensitized to HDM had on average a 5%pred lower level of FEV1. The growth of FEV1 in children and adolescents appears to be impaired not only by symptomatic asthma but also by an increase in the degree of AR and atopy to HDM; sensitization to HDM appears to have a negative impact on the age-related growth in FEV1 even in nonasthmatic subjects without evidence of AHR.
Behavioral choice theory can enhance our understanding of drug dependence and other behavioral disorders
Authors: Stephen T. Higgins
Journal: Behavioral and Brain Sciences (1996)

Abstract I support the major theme of Heyman's target article that behavioral choice theory can enhance our understanding of drug dependence, but I raise concerns about the critique of the operant model of drug dependence, the underscoring of melioration to the exclusion of other theories of choice, and assertions about the unique effects of drug reinforcement.
P81 The efficacy of a nurse led, primary care, acute asthma service in reducing short stay hospital admissions
Authors: G. J. Connett, P. Lovegrove, S. Lovick, J. P. Legg
Journal: Thorax (2011)

<h3></h3> Current interventions to decrease acute asthma admissions during childhood have achieved limited benefits. We hypothesised that a community asthma nurse service, providing rapid access consultations and an out of hours telephone service, might be an effective strategy in reducing potentially avoidable short stay hospital admissions (&lt;24 h). We conducted a prospective observational study of the impact of such a service over a 1-year period (2010) using the previous 12 months as a historical control group (2009). There were 176 (64%) fewer short stay admissions during the intervention period compared with the previous year. The reduction in admissions resulted in gross savings to the NHS of approximately £125 000 based on the national payment by results tariff of £709 per asthma admission. There were 149 referrals to the asthma nurse service. 53% were self-referrals. 39 children with poorly controlled asthma were referred by the asthma nurse for hospital assessment. Of these 38 were subsequently admitted for in-patient treatment and 1 was discharged from the emergency department after 4 h. 21 children were judged to be relatively mild and would not have needed hospital admission if referred. 89 cases would either have been referred for hospital assessment or families would have self-referred to hospital if the service was not available. For this group it was judged by the attending nurse that their interventions had avoided hospital admission. The reduction in short stay admissions was impressive and greater than the number of patient episodes that were addressed by the service. We suspect that this was a knock on effect of good practices being repeated and disseminated within the community without necessarily re-engaging with the service. The number of non-elective short stay asthma admissions has continued to fall in 2011. From January to May 2011 there were just 29 short stay admissions which is 62% less than the 47 admissions during the same period in 2010. We suggest that this model of care is applicable to many other localities and could result in substantial cost savings to the NHS while providing appropriate care to patients in their homes.
Physicians and Caries Prevention
Authors: Helen C. Gift
Journal: JAMA (1984)

Physicians are aware of and support selected caries preventive techniques involving fluoride, particularly community water fluoridation, fluoridating school water supplies, and the prescription of dietary fluoride supplements. Physicians are generally less informed about the relative worth of other caries preventive measures. The role of the practicing physician in the provision of caries prevention methods is a very active one, with physicians prescribing fluoride supplements, counseling on diet, and providing oral hygiene education. Children would be better served in caries prevention if the interest and initiative of the medical practitioners were encouraged and current information was made available to them. These findings represent the preliminary analysis of a mailed survey to a stratified, systematic sample of 2,000 physicians who treat child patients in the nation.
Phase II Trial of Nanoparticle Albumin-Bound Paclitaxel, Carboplatin, and Bevacizumab in First-line Patients with Advanced Nonsquamous Non-small Cell Lung Cancer
Authors: Craig Reynolds, David Barrera, Robert Jotte, Alexander I. Spira, Charles Weissman, Kristi A. Boehm, Sharon Pritchard, Lina Asmar
Journal: Journal of Thoracic Oncology (2009)
Interleukin-4 receptor expression by human B cells: Functional analysis with a human interleukin-4 toxin, DAB389IL-4
Authors: Haifa H. Jabara, Donata Vercelli, Lynda C. Schneider, Diane P. Williams, Frank S. Genbauffe, Louis R. Poisson, Cory A. Waters, Raif S. Geha
Journal: Journal of Allergy and Clinical Immunology (1995)
Case 3-1973
Authors: Richard C. Cabot, Benjamin Castleman, Robert E. Scully, Betty U. McNeely, Raymond D. Adams, Charles R. Plank
Journal: New England Journal of Medicine (1973)

Presentation of CaseA 72-year-old man was admitted to the hospital because of a neurologic disorder.He had been well until five weeks previously, when a rapidly progressive disturbance of gait developed, accompanied by anorexia, impaired memory, somnolence and the loss of 6 kg in weight. He was known to have a "nodule" in the left lung for many years. On admission to another hospital neurologic examination showed that the gait was unsteady and shuffling, and the speech was slow. The laboratory findings were for the most part within the normal range. The urine contained 5 to 7 white cells . . .
Ratio of girls to boys in India continues to decline
Authors: S. Kumar
Journal: BMJ (2003)

The continuous decline in numbers of girls in the age group 0-6 years compared with boys in several states has shocked demographers in India and has made policy makers sit up and take notice. A new report, Missing , released by the United Nations Population Fund on 20 October, maps the adverse sex ratio among children.

India's population stood at 1.03 billion on 1 March 2001, having risen 21% between 1991 and 2001. “What did not rise, but rather declined shockingly, was the sex ratio,” says the report.

The sex ratio, calculated as number of girls per 1000 boys in the 0-6 age group, declined from 945 girls per 1000 …
34 WEANING OF HBV PROPHYLAXIS AFTER LIVER TRANSPLANTATION: PRELIMINARY RESULTS IN PATIENTS WITH UNDETECTABLE CCCDNA IN LIVER TISSUE
Authors: I. Lenci, G. Tisone, D. Di Paolo, F. Marcuccilli, L. Tariciotti, M. Ciotti, T. Guenci, C.F. Perno, M. Angelico
Journal: Journal of Hepatology (2009)
GALLSTONES IN THE AMPULLA OF VATER
Authors: E. STARR JUDD
Journal: JAMA (1930)

The bile in passing from the liver to the intestine passes through a duct of more or less uniform diameter, which is suddenly narrowed at the point where it enters the duodenum at the papilla of Vater. Anatomically a stone would be most likely to meet resistance at this point in its passage down the common bile duct. Likewise at this point the flow of bile would be most easily obstructed. The average diameter of the opening at the tip of the papilla is about 3.5 mm. Just proximal to this opening is found the dilated pouch, approximately 1 cm. in diameter, into which the common bile duct and pancreatic duct usually empty. This is the so-called diverticulum or ampulla of Vater. Fenger, many years ago, described the symptoms of stone lodged in the ampulla, the ball-valve stone of Fenger. Because a stone at this point causes a somewhat characteristic
Tc-99m HMPAO SPECT of the Brain in a Patient with Striopallidodentate Calcifications
Authors: R DIERCKX, G JORENS, B APPEL, F HILTE, J VANDEVIVERE, P P DE DEYN, G A PARIZEL
Journal: Clinical Nuclear Medicine (1991)

CT scan in a 52-year-old woman, admitted because of grand mal seizure, showed striopallidodentate calcifications due to postoperative hypoparathyroidism. This patient report stresses the possibility of cortical metabolic involvement in this disorder, as shown on Tc-99m HMPAO brain SPECT, despite the absence of cognitive defects.
Arterial ammonia and clinical risk factors for encephalopathy and intracranial hypertension in acute liver failure
Authors: William Bernal, Catherine Hall, Constantine J. Karvellas, Georg Auzinger, Elizabeth Sizer, Julia Wendon
Journal: Hepatology (2007)

High circulating ammonia concentrations are common in patients with acute liver failure (ALF) and are associated with hepatic encephalopathy (HE) and intracranial hypertension (ICH). Other risk factors are poorly characterized. We evaluated the relation of the admission arterial ammonia concentration and other clinical variables with the development of HE and ICH. Arterial ammonia was measured on admission to the intensive care unit in 257 patients; 165 had ALF and severe HE, and there were 3 control groups: acute hepatic dysfunction without severe HE (n = 50), chronic liver disease (n = 33), and elective surgery (n = 9). Variables associated with ICH and HE were investigated with regression analysis. Ammonia was higher in ALF patients than controls. An independent risk factor for the development of severe HE and ICH, a level greater than 100 mumol/L predicted the onset of severe HE with 70% accuracy. The model for end-stage liver disease (MELD) score was also independently predictive of HE, and its combination with ammonia increased specificity and accuracy. ICH developed in 55% of ALF patients with a level greater than 200 mumol/L, although this threshold failed to identify most cases. After admission, ammonia levels remained high in those developing ICH and fell in those who did not. Youth, a requirement for vasopressors, and renal replacement therapy were additional independent risk factors.Ammonia is an independent risk factor for the development of both HE and ICH. Additional MELD scoring improved the prediction of HE. Factors other than ammonia also appear important in the pathogenesis of ICH. Ammonia measurements could form part of risk stratification for HE and ICH, identifying patients for ammonia-lowering therapies and invasive monitoring.
The Recovery Time Course of the Endothelial Cell Glycocalyx In Vivo and Its Implications In Vitro
Authors: Daniel R. Potter, John Jiang, Edward R. Damiano
Journal: Circulation Research (2009)

Compelling evidence continues to emerge suggesting that the glycocalyx surface layer on vascular endothelial cells plays a determining role in numerous physiological processes including inflammation, microvascular permeability, and endothelial mechanotransduction. Previous research has shown that enzymes degrade the glycocalyx, whereas inflammation causes shedding of the layer. To track the endogenous recovery of the glycocalyx in vivo, we used fluorescent microparticle image velocimetry (μ-PIV) in mouse cremaster muscle venules to estimate the hydrodynamically relevant glycocalyx thickness 1, 3, 5, and 7 days after enzymatic or cytokine-mediated degradation of the layer. Results indicate that after acute degradation of the glycocalyx, 5 to 7 days are required for the layer to endogenously restore itself to its native hydrodynamically relevant thickness in vivo. In light of these findings, and because demonstrable evidence has emerged that standard cell culture conditions are not conducive to providing the environment and/or cellular conditions necessary to produce and maintain a physiologically relevant cell surface glycocalyx in vitro, we sought to determine whether merely the passage of time would be sufficient to promote the production of a hydrodynamically relevant glycocalyx on a confluent monolayer of human umbilical vein endothelial cells (HUVECs). Using μ-PIV, we found that the hydrodynamically relevant glycocalyx was substantially absent 7 days postconfluence on HUVEC-lined cylindrical collagen microchannels maintained under standard culture conditions. Thus, it remains to be determined how a hydrodynamically relevant glycocalyx surface layer can be synthesized and maintained in culture before the endothelial cell culture model can be used to elucidate glycocalyx-mediated mechanisms of endothelial cell function.
Subcorneal pustular dermatosis (Sneddon-Wilkinson disease) with amicrobial lymph node suppuration and aseptic spleen abscesses
Authors: A. DALLOT, J.M. DECAZES, Y. DROUAULT, M. RYBOJAD, O. VEROLA, P. MOREL, J. MODAI, A. PUISSANT
Journal: British Journal of Dermatology (1988)

Subcorneal pustular dermatosis (SPD) or Sneddon-Wilkinson disease is a skin eruption in which concomitant systemic involvement has not been reported to our knowledge. We describe a patient suffering from SPD of 6 years duration with amicrobial inguinal lymph node suppuration and aseptic spleen abscesses followed by pyoderma gangrenosum.
Former chief of Care Quality Commission hits back at allegations of a cover up
Authors: J. Laurance
Journal: BMJ (2013)

The former head of England’s healthcare watchdog has hit out at critics and the organisation she led for four and a half years, claiming that the investigation alleging that she and former colleagues ordered a report to be deleted was “against natural justice.”

Cynthia Bower, who was chief executive of the Care Quality Commission from its inception in 2009 until her resignation from the £200?000 (€235?000; $310?000) a year post in 2012, has denied that she backed a cover up of an internal review that had detailed the commission’s failings in regulating University Hospitals of Morecambe Bay NHS Foundation Trust in Cumbria.1

Louise Dineley, the …
Sympathetic Activation Causes Focal Adhesion Signaling Alteration in Early Compensated Volume Overload Attributable to Isolated Mitral Regurgitation in the Dog
Authors: Abdelkarim Sabri, Khadija Rafiq, Rachid Seqqat, Mikhail A. Kolpakov, Ray Dillon, Louis J. Dell’italia
Journal: Circulation Research (2008)

We reported that left ventricular (LV) dilatation after 4 weeks of isolated mitral regurgitation (MR) in the dogs is marked by extracellular matrix loss and an increase in adrenergic drive. Given that extracellular matrix proteins and their receptor integrins influence beta-adrenergic receptor (beta-AR) responses in vitro, we tested whether beta1-AR activation modulates focal adhesion (FA) signaling and LV remodeling in these same dogs with isolated MR. Normal dogs were compared with dogs with MR of a 4-week duration and with MR dogs treated with beta(1)-AR blockade (beta(1)-RB) (extended-release metoprolol succinate, 100 mg QD) that was started 24 hours after MR induction. In MR LVs, a decrease in collagen accumulation compared with normal dogs was associated with a decrease in FA kinase tyrosine phosphorylation, along with FA kinase interaction with adapter and cytoskeletal proteins, p130(Cas) and paxillin, respectively, as determined by immunoprecipitation assays. There was increased phosphorylation of stress related molecules p38 mitogen-activated protein kinase (MAPK) and Hsp27 and survival signaling kinases extracellular signal-regulated kinase 1/2 and AKT, with no evidence of cardiomyocyte apoptosis. beta(1)-RB attenuated FA signaling loss and prevented p38 MAPK, Hsp27, and AKT phosphorylation induced by MR and significantly increased LV epicardial collagen content. However, beta(1)-RB did not improve LV endocardial collagen loss or LV dilatation induced by MR. Isolated myocytes from normal and MR dog hearts treated with beta(1)- or beta(2)-AR agonists demonstrated no difference in FA kinase, p38 MAPK, Hsp27, or AKT phosphorylation. These results showed that chronic stimulation of beta(1)-AR during early compensated MR impairs FA signaling that may affect myocyte/fibroblast-extracellular matrix scaffolding necessary for LV remodeling.
Drug Jar for Theriac
Authors: Janet M. Torpy
Journal: JAMA (2007)

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