tbuckley/cabot-search huggingface dataset:
Generalized pruritus as the presenting feature of buUous pemphigoid
Authors: D.J. Barker
Journal: British Journal of Dermatology (1983)

Journal Article Generalized pruritus as the presenting feature of buUous pemphigoid Get access D.J. Barker D.J. Barker Department of Dermatology, Royal Infirmary, Bradford Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 109, Issue 2, 1 August 1983, Pages 237–238, https://doi.org/10.1111/j.1365-2133.1983.tb07090.x Published: 01 August 1983
Bioequivalence of Levothyroxine Preparations: Issues of Science, Publication, and Advertising
Authors: Martin Donohoe
Journal: JAMA (1997)

<h3>To the Editor.</h3> —The article by Dr Dong and colleagues<sup>1</sup>highlights the nature of the problem of scientists' withholding data from colleagues and from peer-reviewed journals; Dr Rennie's Editorial<sup>2</sup>touches on the possible sequelae of such limitations on the free exchange of scientific information involving pharmaceutical and biotechnology-related research. I am concerned about similar problems limiting the nature, scope, and dissemination of results in health services research. With the increasing enrollment of patients in managed care organizations (MCOs), coupled with cuts in government funding of organizations concerned with studying the processes and clinical outcomes of various models of clinical care for different diseases, more and more MCOs are funding internal outcome studies. Ideally, the goals of such research should be to study the effects of different clinical interventions on morbidity, mortality, and quality of life and to develop protocols for achieving enhanced outcomes at reduced cost. However, these organizations are increasingly
The American Journal of Case Reports-Reply
Authors: Patrick J. Savage
Journal: JAMA (1983)

<h3>In Reply.—</h3> We appreciate the opportunity not only to respond to Dr Sataline's request for the<i>AJCR</i>address but also to alert potential authors of exciting new developments with the journal. We are now accepting contributions for the upcoming special issue, "Single Case Reports of Common Maladies." Authors may reserve up to 20 pages in AJCR for their pending publication (if the manuscript will be received within two weeks of the next publication date) by using a major credit card and dialing toll free 1-800-000-0000. Lastly, we relate a recent board decision that is particularly applicable in Dr Sataline's case, our new bulk rate. For publication of five or more case reports by the same author in one issue, we now offer a discount of 15% on the standard publication fee of $2,000 per report. Dr Sataline need send only $22,100 (a savings of $3,900) to: Editor,
OC-073 Calculating the cost-effectiveness of a nutrition support team at a busy district general hospital: Abstract OC-073 Table 1
Authors: M Arsanious, K Eaton, M Burke, O Iyowu, S Gupta, A Tarn
Journal: Gut (2012)

<h3>Introduction</h3> NICE Nutrition Support In Adults (2006) recommends that all Trusts should have a multidisciplinary Nutrition Support Team (NST). Austin &amp; Stroud (2007) suggest its implementation can improve parenteral nutrition (PN) services and potentially reduce PN usage by up to 25%. At Croydon University Hospital (CUH), a multidisciplinary NST was set up in October 2010, consisting of a Consultant Chemical Pathologist, Consultant Gastroenterologist, dietians and pharmacists. It combined the previous PN team with the enteral nutrition (EN) team with the aim to optimise the EN of patients thereby reducing inappropriate PN usage as recommended by NCEPOD 2010. We aimed to investigate the use of PN 1 year prior to the implementation of a multidisciplinary NST and compare this to the use of PN 1 year post-implementation at CUH. <h3>Methods</h3> Case notes of patients who had received PN at CUH between 1st October 2009 and 30th September 2010 were obtained and a retrospective analysis of each patient9s duration on PN was made and compared to prospective data, obtained from the start of the introduction of a multidisciplinary NST on 1st October 2010, until September 30th 2011. The final cost of PN was obtained from the hospital pharmacy and cost-savings were calculated. <h3>Results</h3> Data obtained before and after implementation of NST: The total cost of PN per day is £156.60. The median number of days was reduced by 1 day. In the year following the introduction of the NST, 60 patients received PN (saving 60 days of PN), 12 patients were successfully prevented from receiving PN (saving 72 days of PN). The total number of PN days saved was 132, resulting in a total cost saving of £20 671.20. This does not take into consideration the reduction in PN days as result of reduced waiting time for procedures to facilitate EN. <h3>Conclusion</h3> Implementation of NST resulted in: 12 patients (40%) were successfully prevented from inappropriately starting PN and the median duration of PN reduced by 1 day - A total reduction of <b>132 less PN days.</b> The number of peripheral PN days was reduced by 189.5 days. A reduction in the number of patients on PN awaiting a procedure to facilitate EN. A conservative estimate of <b>£20</b> <b>671.20</b> was saved as a result. <h3>Competing interests</h3> None declared. <h3>References</h3> 1. <b>Austin</b>, Stroud. 2007. 2. <i>Nutrition Support In Adults</i>. NICE, 2006. 3. <i>A Mixed Bag</i>. NCEPOD, 2010.
A MEMORABLE PATIENT
Authors: J. Barlow
Journal: BMJ (1995)

I had worked for three years as registrar to the late Sir John McMichael and Professor John Shillingford at the Hammersmith Hospital in London. I had gained experience in examination of the heart and had established auscultation and phonocardiography among my principal interests. On returning to Johannesburgh in 1958 I diagnosed a left atrial myxoma in an elderly man and, a year later, one in the right atrium of a middle aged woman. Left heart catheterisation was not yet practised and the clinical diagnosis of cardiac myxoma presented a …
An Expression of Thanks to Our Loyal Reviewers
Authors: William R. Barclay
Journal: JAMA (1976)

The holiday season at the year's end is traditionally observed by greeting friends with cards, calls, and visits and by recalling the many favors and blessings that friendship has bestowed on us. We of the editorial staff ofThe Journalcount our friends in the many hundreds, and we are especially grateful to those of you who have served as consultants and reviewers. Reviewing a scientific manuscript is a time-consuming and often difficult chore, yet our reviewers do this for us without special recognition or compensation. We have seriously considered publishing the names of those who have reviewed papers in the preceding 12 months, but we are afraid that in such a list, we may unwittingly omit those who may deserve the greatest credit. If our reviewers were not so widely scattered, a party at which we could shake your hands and drink to your health would be a most
Devices for Insulin Administration
Authors: Jean-Louis Selam, M Arthur Charles
Journal: Diabetes Care (1990)

There is a significant need for revised, safe, and more effective insulin-delivery methods than subcutaneous injections in the treatment of both type I (insulindependent) and type II (non-insulin-dependent) diabetes. The aim of this review is to describe the rationale and methods for better use of injection and infusion devices for intensive insulin therapy and to describe results of animal and human research that will lead to an implantable artificial pancreas. Injection devices, e.g., jet injectors, insulin pens, and access ports, cannot be considered as a major breakthrough in the quest for improved control, although they may improve the patient's comfort. External pumps have benefits over multiple injections and conventional insulin therapy only in specific subgroups of patients, e.g., those with recurrent severe hypoglycemia, but only when used by experienced personnel. The external artificial pancreas (Biostator) is also to be used by experienced personnel for limited clinical and research applications, e.g., surgery of the diabetic patient. The development of an implantable version of the artificial pancreas is linked to progress in the field of reliable long-duration glucose sensors. Finally, programmable implantable insulin pumps, used as an open-loop delivery system, are the most promising alternative to intensive subcutaneous insulin strategies in the short term, although clear evidence of improved safety and efficacy remains to be documented.
Thrombolytic activity of a novel plasminogen activator, LY210825, compared with recombinant tissue-type plasminogen activator in a canine model of coronary artery thrombosis.
Authors: C V Jackson, V G Crowe, T J Craft, J L Sundboom, B W Grinnell, J L Bobbitt, P J Burck, J F Quay, G F Smith
Journal: Circulation (1990)

LY210825, a recombinant tissue-type plasminogen activator (rt-PA), which contains the kringle-2 and serine protease functional domains of native tissue-type plasminogen activator, was previously produced by site-directed mutagenesis in a Syrian hamster cell line. We studied the thrombolytic potential of this molecule in a canine thrombosis model. Male hounds (16-22 kg) were anesthetized; a 2.0-cm segment of the left circumflex coronary artery (LCX) was isolated proximal to the first main branch, and the dogs were instrumented with an electromagnetic flow probe to measure coronary blood flow. An occlusive thrombus was formed after injury of the intimal surface of the LCX with an electrical current applied by a needle-tipped anode placed distal to the electromagnetic flow probe. After 1 hour of occlusion, either LY210825 or rt-PA was administered intravenously according to the following protocols: 1) a 1-hour infusion of either 0.25 mg/kg LY210825 or 0.4 mg/kg rt-PA, 2) single injections of 0.15-0.6 mg/kg LY210825, and 3) a single injection of 0.45 mg/kg LY210825 and a 3-hour infusion of 1.0 or 1.7 mg/kg rt-PA. Plasma half-lives of LY210825 and rt-PA were 58 +/- 7 and 3.3 +/- 0.3 minutes, respectively. LY210825 produced more rapid reperfusion of the LCX than did rt-PA. In the third study, 90% of the rt-PA-treated vessels reoccluded within 1 hour after cessation of drug, whereas only 25% of the LY210825-treated vessels reoccluded during a 4-hour washout period. There were significant, but relatively small, reductions produced by both plasminogen activators on plasma fibrinogen and plasminogen (25-35% decreases). Because of its longer plasma half-life, LY210825 could be administered intravenously as a single injection. In a canine model of coronary artery thrombosis, LY210825 was a more effective thrombolytic agent than was rt-PA.
Necrotising glomerulonephritis associated with cholesterol microemboli.
Authors: M Goldman, Y Thoua, M Dhaene, C Toussaint
Journal: BMJ (1985)

mediate acting insulins and were studied twice with an interval of one week in between.Patients were randomised to receive either human Actrapid plus human Monotard or human Velosulin plus human Insulatard initially and then received the other combination during the second period of study.All insulins were of U40 strength.The tests began at least 30 minutes after cannulation.After an overnight fast the morning dose of short acting (mean 12-6 IU, range 4-36 IU) and intermediate acting insulin (mean 32-2 IU, range 16-52 IU) was administered by one of us.The insulins were injected perpendicularly into the thigh immediately after mixing in the syringe (Plastipak).The mean (range) ratio between short and inter- mediate acting insulin was 0-39 (0-11-0 90).After 30 minutes a standard liquid meal (2-1 MJ (500 kcal), 56u( carbohydrate) was taken.Blood glucose concentrations and plasma free insulin concentrations (measured by radio- immunoassay after plasma extraction with macrogol (polyethylene glycol)) were measured at regular intervals for four hours.Statistical analysis was by Student's paired t test and Kendall's rank correlation test.Results are given as means (1 SEM).Postprandial blood glucose concentrations rose to higher peaks after short acting plus lente insulin than after short acting plus isophane insulin: from 9.9 (1-3) to 16-5 (1-5) mmol'l (178 (23 4) to 297 (27) mg/l00 ml) at 130 (9) minutes, compared with from 10-5 (1-2) to 13-6 (1-5) mmol/l (189 (21-6) to 245 (27) mg/1 00 ml) (p < 0-01) at 118 (6) minutes (figure).Blood glucose concentrations were significantly different from 105 to 240 minutes.100 *8
Heat shock proteins and cardiac protection
Authors: D Latchman
Journal: Cardiovascular Research (2001)

The heat shock proteins (hsps) are expressed in normal cells but their expression is enhanced by a number of different stresses including heat and ischaemia. They play important roles in chaperoning the folding of other proteins and in protein degradation. In the heart a number of studies have shown that prior induction of the hsps by a mild stress has a protective effect against a more severe stress. Moreover, over-expression of an individual hsp in cardiac cells in culture or in the intact heart of either transgenic animals or using virus vectors, also produces a protective effect, directly demonstrating the ability of the hsps to produce protection. These findings indicate the potential importance of developing procedures for elevating hsp expression in a safe and efficient manner in human individuals using either pharmacological or gene therapy procedures.
Heart Rate Variability in Association with Frequent Use of Household Sprays and Scented Products in SAPALDIA
Authors: Amar J. Mehta, Martin Adam, Emmanuel Schaffner, Jean-Claude Barthélémy, David Carballo, Jean-Michel Gaspoz, Thierry Rochat, Christian Schindler, Joel Schwartz, Jan-Paul Zock, Nino Künzli, Nicole Probst-Hensch, SAPALDIA Team
Journal: Environmental Health Perspectives (2012)

Household cleaning products are associated with adverse respiratory health outcomes, but the cardiovascular health effects are largely unknown.We determined if long-term use of household sprays and scented products at home was associated with reduced heart rate variability (HRV), a marker of autonomic cardiac dysfunction.We recorded 24-hr electrocardiograms in a cross-sectional survey of 581 Swiss adults, ≥ 50 years of age, who answered a detailed questionnaire regarding their use of household cleaning products in their homes. The adjusted average percent changes in standard deviation of all normal-to-normal intervals in 24 hr (24-hr SDNN) and total power (TP) were estimated in multiple linear regression in association with frequency [< 1, 1-3, or 4-7 days/week, unexposed (reference)] of using cleaning sprays, air freshening sprays, and scented products.Decreases in 24-hr SDNN and TP were observed with frequent use of all product types, but the strongest reductions were associated with air freshening sprays. Compared with unexposed participants, we found that using air freshening sprays 4-7 days/week was associated with 11% [95% confidence interval (CI): -20%, -2%] and 29% (95% CI: -46%, -8%) decreases in 24-hr SDNN and TP, respectively. Inverse associations of 24-SDNN and TP with increased use of cleaning sprays, air freshening sprays, and scented products were observed mainly in participants with obstructive lung disease (p < 0.05 for interactions).In predominantly older adult women, long-term frequent use of household spray and scented products was associated with reduced HRV, which suggests an increased risk of cardiovascular health hazards. People with preexisting pulmonary conditions may be more susceptible.
Trends in prevalence and severity of childhood asthma
Authors: H R Anderson, B K Butland, D P Strachan
Journal: BMJ (1994)

<h3>Abstract</h3> <b>Objective</b>: To test the null hypothesis and there has been no change in the prevalence or severity of childhood asthma over recent years. <b>Design</b>: Repeated population prevalence survey with questionnaires completed by parents followed by home interviews with parents. <b>Setting</b>: London borough of Croydon, 1978 and 1991. <b>Subjects</b>: All children in one year of state and private primary schools aged 7 1/2 to 8 1/2 years at screening survey. <b>Main outcome measures</b>: Trends in symptoms, acute severe attacks, and chronic disability. <b>Results</b>: For 1978 and 1991 respectively, the response rates were 4147/4763 and 3070/3786, and home interviews were obtained from 273/288 and 319/395 parents of currently wheezy children. Between 1978 and 1991 there were significant relative increases in prevalence ratios in the 12 month prevalence of attacks of wheezing or asthma (1.16; 95% confidence interval 1.02 to 1.31), the one month prevalence of wheezing episodes (1.78, 1.15 to 2.74), and the one month prevalence of night waking (1.81; 1.01 to 3.23) but not in frequent (&gt;=5) attacks over the past year (1.05; 0.79 to 1.40). There were substantial and significant decreases in the 12 months prevalence of absence from school of more than 10 days due to wheezing (0.52; 0.03 to 0.90), any days in bed (0.67; 0.44 to 1.01), and restriction of activities at home (0.51; 0.31 to 0.83) and an equivalent but not significant fall in speech limiting attacks (0.51; 0.24 to 1.11). <b>Conclusion</b>: The small increase in the prevalence of wheezy children and relatively greater increase in persistent wheezing suggests a change in the environmental determinants of asthma. In contrast and paradoxically the frequency of wheezing attacks remains unchanged and there are indications that severe attacks and chronic disability have fallen by about half; this may be due to an improvement in treatment received by wheezy children.
Pulmonary Calcification in Chronic Dialysis Patients
Authors: J. D. CONGER
Journal: Annals of Internal Medicine (1975)

A prospective study of 31 chronically hemodialyzed patients was made to investigate the incidence and pathology of pulmonary calcification and the relation of the latter to ventilatory function. Fifteen of the patients have died thus far; 9 had evidence of lung calcification. The lesions occurred predominately in alveolar septa and were associated with varying degrees of fibrosis and alveolar septal thickening. Only one patient had X-ray evidence of calcification. An X-ray diffraction analysis showed a predominant pattern of whitlockite (CaMg)3(Po4)2 in deposits. Patients with the severest pulmonary calcification had abnormalities of vital capacity, carbon monoxide diffusion, and Po2. Serum calcium levels were slightly higher in patients with calcification, but there was no measurable association with the duration of dialysis, serum phosphorus, calcium X phosphorus product, magnesium, bicarbonate, or arterial pH. These data show that pulmonary calcification occurs with high frequency in patients undergoing long-term hemodialysis and that such lesions are associated with restrictive and diffusion ventilatory defects.
Abstract 1645: Genome-wide association studies identify several new loci for human pigmentation traits
Authors: Mingfeng Zhang, Abrar Queshi, Jiangwen Zhang, Liming Liang, Jiali Han
Journal: Cancer Research (2012)

Abstract Genome-wide association studies (GWASs) have been widely conducted and numerous new loci have been associated with various outcomes. Multiple GWASs have been completed in the Nurses’ Health Study and the Health Professionals Follow-up Study, and we have accrued more than 15,000 individuals with genome-wide genotype data. More recently, with the data released from the 1000 Genomes Project, we have imputed about 10 million SNPs based on the genotyped SNPs and haplotypes from the 1000 Genomes Project. Based on the knowledge that light human pigmentation is a host risk factor for skin cancer development, we conducted the GWASs on pigmentary traits in multiple GWAS datasets in the two cohorts using the newly imputed data. We systematically evaluated the traits of natural hair color (ordinal coding from blonde, light brown, dark brown to black, excluding red hair color), eye colors (blue, green and brown eye colors as co-dominant outcomes), tanning ability (ordinal coding from practically no tan, moderate tan to deep tan) and the number of sunburns (continuous variable). We adjusted for the four largest principal components of genetic variation in the regression model for each component dataset, and performed a meta-analysis to combine the results of all these datasets. No systematic deviation from the expected distribution was detected for any of these pigmentation GWASs. Using a multistage study design, we identified a new region on chromosome 13q22 associated with natural hair color that reached the GWAS significance level. The most significant SNP in this region reached a p-value of 2.4 ×10−14 (p = 5.4×10−9 in the discovery stage and p = 1.2×10−6 in the replication stage). We also newly identified and replicated the association of a SNP on 1q32.3 with brown eye color (p = 7.0×10−8 in the combined set), a SNP on 5p15 with green eye color (p = 9.1×10−7 in the combined set), and a SNP on 11q25 with the number of sunburns (p = 5.6×10−6 in the combined set). Of note, the SNP associated with the number of sunburns was also associated with the expression of a local gene based on the transcript expression profiling data of 87 HapMap CEU cell lines (NCBI GEO database, accession GSE7792). These novel pigmentation SNPs identified by our GWASs are strong candidates to evaluate skin cancer risk. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 103rd Annual Meeting of the American Association for Cancer Research; 2012 Mar 31-Apr 4; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2012;72(8 Suppl):Abstract nr 1645. doi:1538-7445.AM2012-1645