tbuckley/cabot-search huggingface dataset:
Reply to J. Hornberger et al
Authors: Shelly S. Lo, Kathy S. Albain
Journal: Journal of Clinical Oncology (2010)

We thank Hornberger et al for their letter, and especially for their interesting updated economic analyses based on our study results. They demonstrate that use of the 21-gene recurrence score (RS) assay for estrogen receptor (ER) –positive, lymph node–negative breast cancer results in gains of quality-adjusted years of life and total direct medical savings, even when cost of the assay is included. We agree that their economic analysis may in fact underestimate gains and savings, given the intermediate and late effects of chemotherapy and the costs of treating these events (unmeasured in our study), which could not be factored into their model, as well as work productivity and other issues they mention in their letter. We are now in the early stages of a similar prospective study of treatment decisions in lymph node–positive, ER-positive breast cancer, based on the findings of the Southwest Oncology Group study which showed, like the lymph node–negative data, that patients with very low RS do not appear to benefit from chemotherapy. We would be interested in the findings from a similar economic analysis utilizing the 21-gene RS assay in node-positive, ER-positive breast cancer.
Idiopathic Focal Segmental Glomerulosclerosis — New Lessons from Kidney Transplantation
Authors: Philippe Lesavre, Jean-Pierre Grünfeld
Journal: New England Journal of Medicine (1996)

The study of renal allografts has provided insight into the pathogenesis of renal diseases.1 In patients with some disorders, such as Liddle's syndrome (in which long-standing hypertension may severely impair renal function), kidney transplantation cures the original disease, demonstrating that the distal tubular defect is intrinsic to the native kidney. In patients with other disorders, the original disease may recur in the graft. In patients with primary hyperoxaluria type I, the disease recurs because the metabolic defect in the liver persists, and in those with various glomerular diseases, the disease recurs because the triggering mechanism, which is often immunologic, is . . .
Infections in Paregoric Addicts
Authors: Frederick J. Oerther, Joseph L. Goodman, A. Martin Lerner
Journal: JAMA (1964)

PAREGORIC, which contains 130 mg of opium per ounce, is now the major narcotic used in Detroit. Its use as an illegal opium source has developed within the last four years (Table 1). Paregoric is ahydroalcoholic solution containing not more than 129.6 mg of powdered opium per 29.573 ml ( 1 fluid oz) or per 283 gm with anise oil, benzoic acid, and camphor. Until April 20, 1964, paregoric was an exempt narcotic in Michigan, and could be purchased at pharmacies without prescription. The drug is usually concentrated by boiling before intravenous instillation. Users often mix paregoric with the amphetamines, secobarbital, glutethimide, other barbiturates, or tripelennamine. The talcum filler of tripelennamine has been associated with diffuse pulmonary granuloma and subsequent pulmonary hypertension.<sup>1</sup>The benzoic acid, camphor, and anise of paregoric are irritants and lead to occlusive sclerosis after intravenous instillation. Therefore, the median cubital vein (most often used by
Allergic rhinitis and its impact on otorhinolaryngology
Authors: P. W. Hellings, W. J. Fokkens
Journal: Allergy (2006)

Allergic rhinitis (AR) is a disease with growing impact on everyday medical practice, as its prevalence has steadily increased during the last decades. Immunoglobulin‐E (IgE)‐mediated airway inflammation may manifest itself as AR, asthma or both. Allergic inflammation in upper and lower airways is now considered as one airway disease, with manifestation of symptoms in upper, lower or global airway. This insight into allergic inflammation of the whole respiratory tract has consequences for the diagnostic and therapeutic approach of affected patients, as highlighted in the ARIA document. In contrast to asthma, the link between AR and associated conditions in the upper airways like rhinosinusitis, nasal polyps, recurrent viral infections, adenoid hypertrophy, tubal dysfunction, otitis media with effusion and laryngitis remains less explored. It is however of utmost importance to consider the aetiological role of IgE‐mediated inflammation of the nasal mucosa in several diseases of the upper respiratory tract, as they represent a large body of patient population seen by the general practitioner as well as the paediatrician, allergologist and otorhinolaryngologist. We here aim at reviewing the current literature on the relationship between AR and conditions in upper airways frequently encountered in everyday clinical practice, and highlight the need for further studies exploring the role of allergic inflammation in the development of these diseases.
Clopidogrel and Percutaneous Coronary Interventions
Authors: Robin P. Choudhury
Journal: JAMA (2003)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Normal expression of the 19-DEJ-1 epitope in two siblings with late-onset junctional epidermolysis bullosa
Authors: A. Stouthamer, C. Nieboer, R.I.F. Van der Waal, M.F. Jonkman
Journal: British Journal of Dermatology (2001)

Journal Article Normal expression of the 19‐DEJ‐1 epitope in two siblings with late‐onset junctional epidermolysis bullosa Get access A. Stouthamer, A. Stouthamer Department of Dermatology, University Hospital Vrije Universiteit, PO Box 7057, 1007 MB Amsterdam, The Netherlands *Department of Dermatology, Groningen University Hospital, PO Box 30001, 9700 RB Groningen, The Netherlands : A. Stouthamer. E‐mail: astouthamer@hotmail.com Search for other works by this author on: Oxford Academic Google Scholar C. Nieboer, C. Nieboer Department of Dermatology, University Hospital Vrije Universiteit, PO Box 7057, 1007 MB Amsterdam, The Netherlands *Department of Dermatology, Groningen University Hospital, PO Box 30001, 9700 RB Groningen, The Netherlands Search for other works by this author on: Oxford Academic Google Scholar R.I.F. Van der Waal, R.I.F. Van der Waal Department of Dermatology, University Hospital Vrije Universiteit, PO Box 7057, 1007 MB Amsterdam, The Netherlands *Department of Dermatology, Groningen University Hospital, PO Box 30001, 9700 RB Groningen, The Netherlands Search for other works by this author on: Oxford Academic Google Scholar M.F. Jonkman M.F. Jonkman Department of Dermatology, University Hospital Vrije Universiteit, PO Box 7057, 1007 MB Amsterdam, The Netherlands *Department of Dermatology, Groningen University Hospital, PO Box 30001, 9700 RB Groningen, The Netherlands Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 144, Issue 5, 1 May 2001, Pages 1054–1057, https://doi.org/10.1046/j.1365-2133.2001.04198.x Published: 01 May 2001 Article history Accepted: 15 December 2000 Published: 01 May 2001
Lack of influence of non-inherited maternal HLA-DR alleles on susceptibility to rheumatoid arthritis.
Authors: A J Silman, E M Hay, J Worthington, W Thomson, L Pepper, J Davidson, P A Dyer, W E Ollier
Journal: Annals of the Rheumatic Diseases (1995)

OBJECTIVE--To reproduce findings from previous reports that non-inherited maternal HLA class II antigens might contribute to rheumatoid arthritis (RA) susceptibility in the offspring. METHODS--Families were recruited from the Arthritis and Rheumatism Council9s National Repository of RA families and HLA-DRB1 alleles were examined in these individuals and their first degree relatives using DNA typing methods. RESULTS--There was no evidence of an increase in either non-inherited maternal HLA-DR4 or the HLA-DRB1 shared epitope as a whole compared with the frequency expected using the non-inherited paternal antigens as controls. CONCLUSIONS--The numbers of probands who were shared epitope negative were small, but we are unable to confirm in these families the findings that non-inherited maternal HLA contributes an additional susceptibility factor to rheumatoid arthritis.
533. Enhanced Transduction of Dendritic Cells by FCgRI-Targeted Adenovirus Vectorsγ
Authors: Ramil E. Sapinoro, Angela P.H. Burgess, Stephen Dewhurst
Journal: Molecular Therapy (2005)

The production of an efficacious HIV-1 vaccine capable of inducing the humoral and cellular arms of the immune system continues to remain a major challenge in AIDS research. Dendritic cells (DC) are an attractive target for vaccine delivery because vaccine antigens presented to DC can potentially activate effector cells involved in immune defense. Adenovirus (Ad) has been widely used as a vector to express foreign proteins in a variety of cell types and tissues. However, this broad tropism represents a drawback when selective gene delivery is desired. In particular, inefficient gene delivery to antigen presenting cells (APC) is attributed to the absence of the Coxsackie and Adenovirus receptor (CAR). Based on the hypothesis that Ad vectors with improved infectivity of APC may be able to promote an enhanced immune response against a vectored antigen, our objective is to selectively deliver Ad vectors to APC by directing virus to the high affinity Fc-gamma Receptor I (FcgRI), constitutively expressed on DC. To this end, we constructed a bi-specific targeting molecule, H22sCAR, consisting of the extracellular domain of CAR (sCAR), a bacteriophage T4 fibritin trimerization domain, and a single-chain antibody molecule (H22) specific for the human FcgRI receptor. H22sCAR was produced in a baculovirus expression system, and was demonstrated to bind both the Ad fiber knob protein and cellular FcgRI. Ad vectors pre-complexed with H22sCAR enhanced the delivery of GFP and luciferase reporter genes to FcgRI-expressing cell lines, and to monocyte-derived DC, when compared with Ad alone or Ad targeted with an irrelevant control protein (Her2sCAR). These data support the hypothesis that FcgRI-targeted Ad vectors may enhance the delivery of target antigen to APC, and lend support to future studies on the use of FcgRI-targeted adenovirus vectors for HIV-1 vaccine development.
The Physician Payment Sunshine Act
Authors: J. G. Merino
Journal: BMJ (2013)

The final regulations from the Physician Payment Sunshine Act require that on 1 August, pharmaceutical and medical device companies start reporting to the Center for Medicare and Medicaid Services (CMS) any payments to licensed physicians or teaching hospitals, as well as any ownership and investment interests held by physicians or their immediate family. These data will be available in a publicly searchable database starting 30 September 2014.

Patients, insurers, and others will be able to search for details on payments or gifts (cash or in kind) over $10 (£6.50; €7.50) to individual physicians and hospitals, including consulting fees, honorariums, charitable contributions (other than samples), royalties, speaker compensation for continuing medical education (CME) events, research grants, gifts, food, …
The Case for Bedside Rounds
Authors: Eugene W. Linfors, Francis A. Neelon
Journal: New England Journal of Medicine (1980)

William Osler was well aware that the patient's bedside was the chief arena of medical education. He told us that there should be "no teaching without a patient for a text, and the best teaching is that taught by the patient himself." 1 Henry Christian left no doubt about Dr. Osler's methods:He would go to a patient's bed, stand (or sometimes sit in a chair), near the head of the bed at the patient's right side, give him a cheery greeting and, if he were a new patient, ask for his history which would then be given by the student . . .
Rationale and Design of the Vitamin D and Type 2 Diabetes (D2d) Study: A Diabetes Prevention Trial
Authors: Anastassios G. Pittas, Bess Dawson-Hughes, Patricia R. Sheehan, Clifford J. Rosen, James H. Ware, William C. Knowler, Myrlene A. Staten
Journal: Diabetes Care (2014)

OBJECTIVE Observational studies suggest that vitamin D may lower the risk of type 2 diabetes. However, data from long-term trials are lacking. The Vitamin D and Type 2 Diabetes (D2d) study is a randomized clinical trial designed to examine whether a causal relationship exists between vitamin D supplementation and the development of diabetes in people at high risk for type 2 diabetes. RESEARCH DESIGN AND METHODS D2d was designed with support from a U34 planning grant from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK). The final protocol was approved by the D2d Research Group, the data and safety monitoring board, and NIDDK. Key eligibility criteria are age ≥30 years, BMI of 24 (22.5 for Asian Americans) to 42 kg/m2, increased risk for diabetes (defined as meeting two of three glycemic criteria for prediabetes established by the American Diabetes Association [fasting glucose 100–125 mg/dL (5.5–6.9 mmol/L), 2-h postload glucose after 75-g glucose load 140–199 mg/dL (7.7–11.0 mmol/L), hemoglobin A1c 5.7–6.4% (39–46 mmol/mol)]), and no hyperparathyroidism, nephrolithiasis, or hypercalcemia. D2d participants are randomized to once-daily vitamin D3 (cholecalciferol 4,000 IU) or placebo and followed for an average of 3 years. The primary end point is time to incident diabetes as assessed by laboratory criteria during the study or by adjudication if diagnosed outside of D2d. Recruitment was initiated at the end of 2013. CONCLUSIONS D2d will test whether vitamin D supplementation is safe and effective at lowering the risk of progression to diabetes in people at high risk for type 2 diabetes.
Altruism: Brand management or uncontrollable urge?
Authors: Daniel Read
Journal: Behavioral and Brain Sciences (2002)

The act-pattern model of altruism is primarily a brand-equity model, which holds that being altruistic can be traded for social benefits. This is a variant of the “selfish” altruism that Rachlin decries, with altruism being dictated by cold calculations. Moreover, personal and social “self-control” may not be as similar as Rachlin suggests – although we have good (biological) reasons to sacrifice the interests of our current selves in favour of our future selves, we have no such reason to sacrifice ourselves for our neighbours. When we do sacrifice ourselves – giving in to true altruism – we will be repaid with extinction.
Widespread Muscle Expression of an AAV9 Human Mini-dystrophin Vector After Intravenous Injection in Neonatal Dystrophin-deficient Dogs
Authors: Joe N Kornegay, Juan Li, Janet R Bogan, Daniel J Bogan, Chunlian Chen, Hui Zheng, Bing Wang, Chunping Qiao, James F Howard, Xiao Xiao
Journal: Molecular Therapy (2010)

Duchenne (DMD) and golden retriever (GRMD) muscular dystrophy are caused by genetic mutations in the dystrophin gene and afflict striated muscles. We investigated systemic gene delivery in 4-day-old GRMD dogs given a single intravenous injection of an AAV9 vector (1.5 × 1014 vector genomes/kg) carrying a human codon-optimized human mini-dystrophin gene under control of the cytomegalovirus (CMV) promoter. One of the three treated dogs was euthanized 9 days later due to pre-existing conditions. Scattered mini-dystrophin-positive myofibers were seen by immunofluorescent (IF) staining in numerous muscles. At the end of the 16-week study, the other two dogs showed generalized muscle expression of mini-dystrophin in ∼15% to nearly 100% of myofibers. Western blot and vector DNA quantitative PCR results agreed with the IF data. Delayed growth and pelvic limb muscle atrophy and contractures were seen several weeks after vector delivery. T-2 weighted magnetic resonance imaging (MRI) at 8 weeks showed increased signal intensity compatible with inflammation in several pelvic limb muscles. This marked early inflammatory response raised concerns regarding methodology. Use of the ubiquitous CMV promoter, extra-high vector dose, and marked expression of a human protein in canine muscles may have contributed to the pathologic changes seen in the pelvic limbs. Duchenne (DMD) and golden retriever (GRMD) muscular dystrophy are caused by genetic mutations in the dystrophin gene and afflict striated muscles. We investigated systemic gene delivery in 4-day-old GRMD dogs given a single intravenous injection of an AAV9 vector (1.5 × 1014 vector genomes/kg) carrying a human codon-optimized human mini-dystrophin gene under control of the cytomegalovirus (CMV) promoter. One of the three treated dogs was euthanized 9 days later due to pre-existing conditions. Scattered mini-dystrophin-positive myofibers were seen by immunofluorescent (IF) staining in numerous muscles. At the end of the 16-week study, the other two dogs showed generalized muscle expression of mini-dystrophin in ∼15% to nearly 100% of myofibers. Western blot and vector DNA quantitative PCR results agreed with the IF data. Delayed growth and pelvic limb muscle atrophy and contractures were seen several weeks after vector delivery. T-2 weighted magnetic resonance imaging (MRI) at 8 weeks showed increased signal intensity compatible with inflammation in several pelvic limb muscles. This marked early inflammatory response raised concerns regarding methodology. Use of the ubiquitous CMV promoter, extra-high vector dose, and marked expression of a human protein in canine muscles may have contributed to the pathologic changes seen in the pelvic limbs.
Carcinoma Metastasis to Talus and Metatarsals
Authors: J.R. Wilkie
Journal: JAMA (1969)

<h3>To the Editor:—</h3> We were interested to read recently inThe Journal(<b>208</b>:2163, 1969) the account by Paul et al of the patient whose adenocarcinoma of the lung had metastasized to the great toe of the left foot. They commented on the rarity with which malignant tumors metastasize to the foot, as they had found only 13 such cases previously described in the literature. Recently a patient of ours was found to have a papillary moderately well-differentiated transitional cell carcinoma of the bladder with metastases to the left talus as well as the left, first, second, third, and fourth metatarsals, and the presence of the metastases was confirmed at postmortem examination. <h3>Report of a Case:—</h3> The patient was an 87-year-old woman, who was admitted to Mile End Hospital, London in June 1969. Two years before admission the patient had had an episode of hematuria but refused to have any
Successful treatment for hypopharyngeal cancer in a patient with superficial esophageal cancer by endoscopic submucosal dissection
Authors: Y. Fujita, M. Hiramatsu, M. Kawai, K. Tashiro, E. Umegaki, S. Tokioka, Y. Egashira, K. Higuchi, N. Tanigawa
Journal: Endoscopy (2008)

A 68-year-old man with a history of laryngectomy for laryngeal cancer 3 years earlier was diagnosed with superficial esophageal squamous cell carcinoma (ESCC). In addition, a slightly elevated lesion (1.6 cm) was detected synchronously in the posterior wall of the hypopharynx ([Fig. 1 ] a). Using a narrow-band imaging (NBI) system with magnifying endoscopy (GIF TYPE H260Z; Olympus), this lesion displayed a clearly demarcated brownish area ([Fig. 1 ] b) and the intrapapillary capillary loop (IPCL), which was advocated by Inoue et al. [1], took on irregular shapes ([Fig. 1 ] c). For treatment of the hypopharyngeal lesion, endoscopic submucosal dissection (ESD) was performed under general anesthesia followed by subtotal esophagectomy. A mucosal incision was made with the flex knife and the subepithelial tissue was cut with a hook knife. Macroscopic examination of the resected specimen (3.5 × 3.0 cm) revealed cancer spread over an area of 1.7 × 1.3 cm ([Fig. 2 ] a). Histologically, noninvasive squamous cell carcinoma was limited to the epithelial layers without either vessels or lymphatic infiltration, and both horizontal and vertical margins were sufficient ([Fig. 2 ] b). Immunohistochemistry revealed that p53-positive cells were widespread in the outer basal cell layer ([Fig. 2 ] c). This observation led to a diagnosis of squamous cell carcinoma of the hypopharynx, not a dysplastic lesion or regenerative changes.
Relation of Adrenal Androgen to Insulin Levels
Authors: Elizabeth Barrett-Connor
Journal: Annals of Internal Medicine (1993)

Letters15 May 1993Relation of Adrenal Androgen to Insulin LevelsElizabeth Barrett-Connor, MDElizabeth Barrett-Connor, MDSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-118-10-199305150-00020 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail IN RESPONSE:We thank Dr. Nestler for his comments. We are, of course, aware of his interesting work on the relation between insulin and DHEA-sulfate levels. He suggests that we study the change in adrenal androgens in the newly treated patients with diabetes in our cohort. The study Dr. Nestler proposes could be done in a controlled fashion in a clinical setting. However, we do not treat the participants in the Rancho Bernardo study; it is an observational study only. Author, Article, and Disclosure InformationAuthors: Elizabeth Barrett-Connor, MDAffiliations: PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 15 May 1993Volume 118, Issue 10Page: 826KeywordsAndrogensCohort studiesInsulinObservational studies ePublished: 15 August 2000 Issue Published: 15 May 1993 Copyright & PermissionsCopyright © 1993 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Alteration of the Course of Hypertension in the Spontaneously Hypertensive Rat
Authors: Edward D. Freis, Dennis Ragan, Harold Pillsbury, Mary Mathews
Journal: Circulation Research (1972)

The blood pressure of spontaneously hypertensive rats was controlled at low normotensive levels, using antihypertensive drugs for a 6-month period beginning when the rats were 3 months of age. Treatment was then withdrawn and the rats observed for an additional 4 months, until they were 13 months of age. Treatment with antihypertensive drugs arrested the progression of the hypertension and the secondary pathology for the duration of the treatment period. Following withdrawal of drugs the blood pressure did not rise to the level of the controls of a similar age, but rather it returned to the level that existed before treatment began and then progressed at the same rate that the controls exhibited when they were 3-7 months of age. Pathological changes were found only in controls. These results indicate that, although the tendency toward hypertension is inherited, its rate of development depends on environmental factors. The hypertension can be arrested by chemotherapeutic interventions and can be aggravated by excessive salt. The hypertension appears to be a progressive time-dependent process but is independent of biological processes associated with aging per se. Finally, control of blood pressure prevents end-organ damage.