TREATMENT OF LEUKEMIA CUTIS WITH DEMECOLCIN
Authors: E SHANBROM, D KAHN
Journal: Annals of Internal Medicine (1957)

Case Reports1 September 1957TREATMENT OF LEUKEMIA CUTIS WITH DEMECOLCINEDWARD SHANBROM, M.D., DANIEL KAHN, M.D.EDWARD SHANBROM, M.D.Search for more papers by this author, DANIEL KAHN, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-47-3-565 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptAlthough at the time of this writing there have been no original reports in the American literature on the use of demecolcin ("Colcemide"-Ciba) in leukemia, the drug has had considerable use in Europe. The only report in the English literature appeared in theBritish Medical Journalin April, 1955, by Leonard and Wilkinson.1There have been several interesting reviews in the European literature on the effect of demecolcin in various neoplastic conditions.2, 3, 4, 5, 6, 7Although the drug exhibits some antimitotic action in a variety of neoplasms, it is the consensus of all authors that demecolcin is most...Bibliography1. LeonardWilkinson BJJF: Desacetylmethylcolchicine in treatment of myeloid leukemia, Brit. M. J. 1: 874, 1955. CrossrefMedlineGoogle Scholar2. BockGross HER: Leukamie und Tumorbehandlung mit einem nebenalkaloid aus Colchicum autumnale , Acta haemat. 11: 280-300, 1954. CrossrefMedlineGoogle Scholar3. MoeschlinMeyerLichtman SHA: Ein neues Colchicum nebenalkaloid als zytostatikum myeloischer Leukamien, Schweiz. med. Wchnschr. 83: 990 (Oct. 10) 1953. MedlineGoogle Scholar4. BaerAdors BA: Klinische und tierexperimentelle Untersuchungen über die Wirkung einiger moderner cytostatischer Substanzen auf die Phagocytosefahigheit der Leukocyten, Klin. Wchnschr. 32: 199 (Mar. 1) 1954. CrossrefMedlineGoogle Scholar5. BockGross HER: Colchicinwirkungen und Granulocytopoese. Klinische und experimentelle Beobachtungen mit Substanz F aus Colchicum autumnale , Klin. Wchnschr. 31: 816 (Sept. 1) 1953. CrossrefMedlineGoogle Scholar6. LeonardiD'Agnolo PB: Sulla terapia delle leucemiae e del morbo di Hodgkin con desacetilmetilcolchicina alcaloide antimitotico del colchico autumnale, Acta med. Patavina 14: 69, 1954. MedlineGoogle Scholar7. BockGross HER: Zur Therapie der chronischen myeloischen Leukamie, Arztl. Wchnschr. 9: 334 (Apr. 9) 1954. Google Scholar8. ScharLoustalotGross BPF: Demecolcin (Substanz F), ein neues, aus Colchicum autumnale isoliertes Alkaloid mit Starker antimitotischer Wirkung, Klin. Wchnschr. 32: 49 (Jan. 15) 1954. CrossrefMedlineGoogle Scholar9. MeierScharNeipp RBL: Die Wirkung von Demecolcainamiden an Zellen in vitro, Experientia 10: 74 (Feb. 15) 1954. CrossrefMedlineGoogle Scholar10. Wintrobe M: Clinical hematology, 3d Ed., 1951, Lea and Febiger, Philadelphia. Google Scholar11. CostelloCanizeresMontagueBuncke MJOMCM: Cutaneous manifestations of myelogenous leukemia, Arch. Dermat. 71: 605 (May) 1955. CrossrefGoogle Scholar12. Jones R: Medical management of patients with incurable cancer, Veterans Administration Technical Bulletin TB 10-107 (Mar. 10) 1955. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: EDWARD SHANBROM, M.D.; DANIEL KAHN, M.D.Affiliations: West Haven, Connecticut*Received for publication March 9, 1956.From the Medical Service, Veterans Administration Hospital, West Haven, Connecticut.Requests for reprints should be addressed to Edward Shanbrom, M.D., City of Hope Medical Center, Duarte, California.The demecolcin ("Colcemide") used in the treatment of this patient was generously supplied by Dr. John Saunders, of the Ciba Pharmaceutical Co. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byDemecolcine toxicity 1 September 1957Volume 47, Issue 3Page: 565-576KeywordsCellsDrug administrationDrug therapyDrugsLesionsLymph nodesPancreasSpleenUric acidWhite blood cells ePublished: 1 December 2008 Issue Published: 1 September 1957 PDF downloadLoading ...