The Clinical Value of Routine Serum Calcium Analysis
Authors: C E BOONSTRA, C E JACKSON
Journal: Annals of Internal Medicine (1962)

Article1 December 1962The Clinical Value of Routine Serum Calcium AnalysisC. E. BOONSTRA, M.D., F.A.C.P., C. E. JACKSON, M.D., F.A.C.P.C. E. BOONSTRA, M.D., F.A.C.P.Search for more papers by this author, C. E. JACKSON, M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-57-6-963 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe results of serum calcium analysis on nearly 12,000 consecutive individuals appearing for clinical evaluation in a 29-month period are presented in this paper. Interest in this type of survey was stimulated by the occurrence of several cases with asymptomatic parathyroid adenomas during an investigation of the hereditary aspects of hyperparathyroidism (1). The study was facilitated by the availability of an ammonium purpurate method (2) adapted for use in an automatic chemical analyzer.*METHODSThis survey was begun in June 1959, and continued through March 1962, except for a 4-month period from the middle of August 1960, through the middle...References1. JACKSON CE: Hereditary hyperparathyroidism associated with recurrent pancreatitis. Ann. Intern. Med. 49: 829, 1958. LinkGoogle Scholar2. WILLIAMSMOSER MBJH: Colorimetric determination of calcium with ammonium purpurate. Anal. Chem. 25: 1414, 1953. CrossrefGoogle Scholar3. FALES FW: Micromethod for determination of serum calcium. J. Biol. Chem. 204: 577, 1953. CrossrefMedlineGoogle Scholar4. BUCKNERSHIVELY BJA: Determination of serum calcium by a chelating method using a spectrophotometer. Amer. J. Med. Techn. 21: 269, 1955. MedlineGoogle Scholar5. PRASADFLINK ACEB: Effect of carbon dioxide on concentration of calcium in an ultrafiltrate of serum obtained by centrifugation. J. Appl. Physiol. 10: 103, 1957. CrossrefMedlineGoogle Scholar6. CHAMBERSGORDANGOLDMANREIFENSTEIN ELGSLEC: Tests for hyperparathyroidism: tubular reabsorption of phosphate, phosphate deprivation and calcium infusion. J. Clin. Endocr. 16: 1507, 1956. CrossrefMedlineGoogle Scholar7. JACKSONYODERCAYLOR CERPHD: Incidence of hereditary hyperparathyroidism. Clin. Res. 9: 182, 1961. Google Scholar8. RASMUSSENREIFENSTEIN HEC: In Textbook of Endocrinology, 3d Ed., by Williams, R. H., W. B. Saunders Company, Philadelphia, 1962. pp. 817-818. Google Scholar9. RANDALLKEATING RVFR: Serendipity in the diagnosis of primary hyperparathyroidism. Amer. J. Med. Sci. 236: 575, 1958. MedlineGoogle Scholar10. MCGEOWNFIELD MGCM: Asymptomatic hyperparathyroidism. Lancet 2: 1268, 1960. CrossrefMedlineGoogle Scholar11. RIDDICKREISS FAE: Hyperparathyroidism: analysis of recent experiences, clinical spectrum, and diagnostic tests. Ann. Intern. Med. 56: 183, 1962. LinkGoogle Scholar12. KEATING FR: Diagnosis of primary hyperparathyroidism, clinical and laboratory aspects. JAMA 178: 547, 1961. CrossrefMedlineGoogle Scholar13. BIGGARTWILLIS JHJ: Peptic ulceration and endocrine disease in necropsy material. Lancet 2: 938, 1959. CrossrefMedlineGoogle Scholar14. FRAMEHAUBRICH BWS: Peptic ulcer and hyperparathyroidism: a survey of 300 ulcer patients. Arch. Intern. Med. 105: 536, 1960. CrossrefMedlineGoogle Scholar15. MCGEOWNMORRISON MGE: Hyperparathyroidism. Postgrad. Med. J. 35: 330, 1959. CrossrefMedlineGoogle Scholar16. THOMASLOKENGORDANGOLDMAN ANHFGSL: Hypercalcemia of metastatic breast carcinoma. Surg. Forum 11: 70, 1960. MedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Bluffton, IndianaFrom the Departments of Pathology and Internal Medicine, Caylor-Nickel Clinic, Bluffton, Indiana.Sponsored in part by the Caylor-Nickel Research Foundation and United States Public Health Service Grant A 2901.Requests for reprints should be addressed to Charles E. Boonstra, M.D., Caylor-Nickel Clinic, 303 South Main Street, Bluffton, Indiana.*Autoanalyzer, Technicon Instruments Corporation, Chauncey, New York. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byNew Concepts About Familial Isolated HyperparathyroidismEpidemiology of parathyroid disordersA 50 year perspective endocrine neoplasia: clinic to genes and backMultiple endocrine neoplasia type I: general features and new insights into etiologyReview: Primary Hyperparathyroidism, an Update: Incidence, Etiology, Diagnosis, and TreatmentHistologic parathyroid abnormalities in an autopsy seriesThe two-hit theory of neoplasia: Implications for the pathogenesis of hyperparathyroidismChanges in physician behavior and cost savings associated with organizational recommendations on the use of “routine” chest X rays and multichannel blood testsThe investigation of hypercalcaemiaPatientization of the PopulationThe Periodic Health Examination for the AdultThe Periodic Health Examination RevisitedTHOMAS L. DELBANCO, M.D., JOHN NOBLE, M.D.BIOCHEMISTRY OF WELL POPULATIONSARE MULTIPHASIC HEALTH SCREENING PROGRAMMES A DESIRABLE INNOVATION?MULTIPHASIC SCREENING—DEFINITION AND ASSESSMENTBiochemical Screening — A CritiqueUrological Findings in 58 Surgically Verified Cases of Parathyroid AdenomaHypercalcemia and HypertensionJERRY M. EARLL, NEIL A. KURTZMAN, ROBERT H. MOSERHyperparathyroidism Detected by Routine Serum Calcium Analysis Prevalence in a Clinic PopulationCHARLES E. BOONSTRA, M.D., CHARLES E. JACKSON, M.D., F.A.C.P.Stable Calcium Isotopes as Tracers in Studies of Mineral MetabolismPrimary Hyperparathyroidism: Problems for Clinician and ChemistE. J. H. 1 December 1962Volume 57, Issue 6Page: 963-969KeywordsCalciumChildrenClinical pathologyFallsHyperparathyroidismMedical servicesMultiple myelomaParathyroid tumorsVitamin D ePublished: 1 December 2008 Issue Published: 1 December 1962 PDF downloadLoading ...