tbuckley/cabot-search huggingface dataset:
Impact of gender on disease activity, pulmonary function and health status in sarcoidosis patients - King's sarcoidosis questionnaire (KSQ)
Authors: Branislav S. Gvozdenovic, Amit Suresh Patel, Surrinder S. Birring, Violeta Vucinic, Mira Vukovic
Journal: European Respiratory Journal (2013)

Health status impairment in sarcoidosis has been shown to be worse in women. The aim of the study was to determine gender differences in health status, degree of dyspnea, and compare commonly used health status questionnaires.

In a cross-sectional sample of 67 (43 female) sarcoidosis patients pulmonary function, serum ACE and health status were assessed. Health status was assessed using the disease-specific King’s Sarcoidosis Questionnaire (KSQ) with modular scores: General Health Status (GHS), Lung, Medication, Skin, Eyes and GHS–Lung score), the respiratory-specific St Georges Respiratory Questionnaire (SGRQ) and a Generic tool – 15D. Dyspnea was assessed using the MRC dyspnea scale.

Women had significantly lower mean GHS scores (Med 59.9 vs. 83.96, p=0.001) and GHS–Lung scores (Med 66.04 vs. 88.68, p=0.013), as well as higher MRC scores (Med 1 vs. 0, p=0.011). There was no significant difference in SGRQ Total scores (p=0.117) or 15D scores (p=0.055) between men and women. Serum ACE was significantly higher in women (18/43), than in men (4/20) perhaps suggesting more active disease. KCO (%) values were significantly lower in women in comparison with men (Med 89.5 vs. 103, p=0.036) suggesting more severe pulmonary impairment. There were no significant differences in other pulmonary function tests.

In this cohort of patients sarcoidosis in women was associated with greater dyspnea, a more frequent active inflammatory process and lower lung diffusion tests in comparison with men. In comparison to the SGRQ and 15D, the KSQ discriminates worse health status significantly better in sarcoidosis patients.
Cost-effectiveness of interferon alfa in chronic myelogenous leukemia.
Authors: N L Liberato, S Quaglini, G Barosi
Journal: Journal of Clinical Oncology (1997)

To evaluate the cost-effectiveness of interferon alfa (IFN alpha) treatment of patients with chronic myelogenous leukemia relative to conventional chemotherapy.A decision-analysis model that involved a multistate Markov process was designed to estimate the expected cost and quality-adjusted life expectancies for two cohorts of patients to be administered conventional chemotherapy or IFN alpha. Two IFN alpha strategies were modeled: prolonged treatment for patients who achieved a hematologic response (scenario A) or only for patients who achieved a cytogenetic remission in a 2-year period (scenario B). Data on response and transition probabilities between health states were obtained from the literature by a MEDLINE search and pooled with a meta-analytic method. Costs were based on local charges. Expected survival was adjusted for quality of life on the basis of an expert panel judgment.Baseline analysis showed IFN alpha treatment to increase the quality-adjusted life expectancy by 15.5 and 12.5 months relative to conventional chemotherapy, in scenarios A and B, respectively. Marginal cost-effectiveness was $89,500 and $63,500 per quality-adjusted life-year (QALY) gained. Sensitivity analysis confirmed IFN alpha as the most effective approach. Cost-effectiveness results were sensitive to the cost of IFN alpha therapy and to the assumptions about the rate of cytogenetic remission. Reducing the drug dose, as suggested by a recent report, would decrease the marginal cost-effectiveness to less than $20,000.IFN alpha is substantially superior to conventional chemotherapy in terms of quality-adjusted survival, but, at the current doses, marginal cost-effectiveness ranges from $50,000 to $100,000 per QALY gained under most of our assumptions.
Effect of Tissue Injury on Tumorigenesis Induced by Murine Sarcoma Virus (Harvey) 2
Authors: W. R. Thomas, E. J. Aw, J. M. Papadimitriou, P. J. Simons
Journal: JNCI Journal of the National Cancer Institute (1974)

Journal Article Effect of Tissue Injury on Tumorigenesis Induced by Murine Sarcoma Virus (Harvey) Get access W. R. Thomas, W. R. Thomas 4Department of Microbiology, University of Western Australia, Perth Medical Centre, Shenton Park, Western Australia 6008. Search for other works by this author on: Oxford Academic PubMed Google Scholar E. J. Aw, E. J. Aw 4Department of Microbiology, University of Western Australia, Perth Medical Centre, Shenton Park, Western Australia 6008. Search for other works by this author on: Oxford Academic PubMed Google Scholar J. M. Papadimitriou, J. M. Papadimitriou 5Department of Pathology, University of Western Australia. Search for other works by this author on: Oxford Academic PubMed Google Scholar P. J. Simons P. J. Simons 4Department of Microbiology, University of Western Australia, Perth Medical Centre, Shenton Park, Western Australia 6008. Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 53, Issue 3, September 1974, Pages 763–766, https://doi.org/10.1093/jnci/53.3.763 Published: 01 September 1974 Article history Received: 04 January 1974 Accepted: 30 May 1974 Published: 01 September 1974
Prometheus and progenitors
Authors: Anna Mae Diehl
Journal: Hepatology (2014)

The Hippo-signaling pathway is an important regulator of cellular proliferation and organ size. However, little is known about the role of this cascade in the control of cell fate. Employing a combination of lineage tracing, clonal analysis, and organoid culture approaches, we demonstrate that Hippo pathway activity is essential for the maintenance of the differentiated hepatocyte state. Remarkably, acute inactivation of Hippo pathway signaling in vivo is sufficient to dedifferentiate, at very high efficiencies, adult hepatocytes into cells bearing progenitor characteristics. These hepatocyte-derived progenitor cells demonstrate self-renewal and engraftment capacity at the single-cell level. We also identify the NOTCH-signaling pathway as a functional important effector downstream of the Hippo transducer YAP. Our findings uncover a potent role for Hippo/YAP signaling in controlling liver cell fate and reveal an unprecedented level of phenotypic plasticity in mature hepatocytes, which has implications for the understanding and manipulation of liver regeneration.
Synergistic activity of BET protein antagonist-based combinations in mantle cell lymphoma cells sensitive or resistant to ibrutinib
Authors: Baohua Sun, Bhavin Shah, Warren Fiskus, Jun Qi, Kimal Rajapakshe, Cristian Coarfa, Li Li, Santhana G. T. Devaraj, Sunil Sharma, Liang Zhang, Michael L. Wang, Dyana T. Saenz, Stephanie Krieger, James E. Bradner, Kapil N. Bhalla
Journal: Blood (2015)
Copy Number Changes Are Associated with Response to Treatment with Carboplatin, Paclitaxel, and Sorafenib in Melanoma
Authors: Melissa A. Wilson, Fengmin Zhao, Sanika Khare, Jason Roszik, Scott E. Woodman, Kurt D'Andrea, Bradley Wubbenhorst, David L. Rimm, John M. Kirkwood, Harriet M. Kluger, Lynn M. Schuchter, Sandra J. Lee, Keith T. Flaherty, Katherine L. Nathanson
Journal: Clinical Cancer Research (2015)

Copy number alterations have been shown to be involved in melanoma pathogenesis. The randomized phase III clinical trial E2603: carboplatin, paclitaxel, ± sorafenib (CP vs. CPS) offers a large collection of tumor samples to evaluate association of somatic mutations, genomic alterations, and clinical outcomes, prior to current FDA-approved therapies.Copy number and mutational analysis on 119 pretreatment samples was performed.CPS therapy was associated with improved progression-free survival (PFS) compared with CP in patients with tumors with RAF1 (cRAF) gene copy gains (HR, 0.372; P = 0.025) or CCND1 gene copy gains (HR, 0.45; P = 0.035). CPS therapy was associated with improved overall survival (OS) compared with CP in patients with tumors with KRAS gene copy gains (HR, 0.25; P = 0.035). BRAF gene copy gain and MET amplification were more common in samples with V600K versus V600E mutations (P < 0.001), which was validated in The Cancer Genome Atlas (TCGA) dataset.We observed improved treatment response with CPS in patients with melanoma whose tumors have RAF1 (cRAF), KRAS, or CCND1 amplification, all of which can be attributed to sorafenib targeting CRAF. These genomic alterations should be incorporated in future studies for evaluation as biomarkers.
Plasma lactate dehydrogenase: a marker of disease activity in cryptogenic fibrosing alveolitis and extrinsic allergic alveolitis?
Authors: S P Matusiewicz, I J Williamson, P J Sime, P H Brown, P R Wenham, G K Crompton, A P Greening
Journal: European Respiratory Journal (1993)

Total plasma lactate dehydrogenase (LDH) activity may be elevated in cryptogenic fibrosing alveolitis (CFA) and extrinsic allergic alveolitis (EAA), and may be a useful monitor of disease progress. In a retrospective, primary referral centre study, we compared LDH at presentation, prior to bronchoalveolar lavage BAL, and after treatment and follow-up with changes in pulmonary function, in patients with CFA, EAA and pulmonary sarcoidosis. Plasma levels of LDH at presentation in CFA (n = 47) and EAA (n = 10) were significantly higher than in patients with sarcoidosis (n = 36). LDH activity decreased in patients with improving lung function (EAA, p = 0.008; CFA, p = 0.02), whereas it increased in CFA patients with deteriorating lung function (p = 0.015). Total plasma LDH is a simple, though nonspecific test, which appears to reflect changes of disease activity in patients with CFA and EAA.
Duration of DNA Synthesis in Hyperplastic Alveolar Nodules of C3H/He Mouse Mammary Gland
Authors: M. R. Banerjee, Ruby J. Walker
Journal: JNCI Journal of the National Cancer Institute (1967)

Duration of DNA synthesis in the cells of the outgrowths of hyperplastic alveolar nodules (HAN) of C3H/He mouse mammary gland was studied by autoradiographic methods. The average duration of DNA synthesis in HAN outgrowth cells was estimated as 13.7 hours. Earlier it was shown that DNA synthesis in mouse mammary gland was influenced by the hormones, estradiol and progesterone, and the DNA replication time (8.2 hours) of the prelactating tissue after transplantation into virgin host changed to a value (21.5 hours) similar to that (20.7 hours) of the normal mammary cells of virgin mice. This indicates that the duration of DNA synthesis in mammary cells is adjustable to the endogenous hormonal environment of the host. The intermediate value (13.7 hours) of the duration of DNA synthesis in HAN outgrowth cells in virgin host was interpreted as due to an altered sensitivity of these cells to the host's hormonal control on DNA synthesis.
Smoking rate in 12-15 years old Parisian school is sensitive to political decisions
Authors: Bertrand Dautzenberg, Maryvonne Noel, Pierre Birkui, Marie-Dominique Dautzenberg
Journal: European Respiratory Journal (2012)

The first cancer plan was launched with force, funded and followed with a strong commitment by the head of state. The second cancer plan included only limited measures against smoking and was accompanied by the cessation of funding and lack of control.  Methods: The cross-sectional survey conducted annually PST on 2% of students per class randomly and distributed and collected with the help of the Rector of the Academy of Paris gives an image of smoking among college students, we compare the rate of smoking daily among college students (12-15 years) the 2 years preceding each of the plans (2000-2001 and 2006-2007) in the second and third years of each of the two plans (2010-2011 and 2004 -2005).  Results: Half the leading cancer plan has helped lower smoking rate of 12.0% to 5.8% (13.6% to 5.7% in girls and 10.3% to 5.9% in boys) to 52% of relative decline. For the entire foreground is the relative decline of 73% with a rate of smoking at the end of plan by 3.2%.  The first phase of second cancer plan has had the opposite effect with a rise in smoking rates by 3.7% to 4.5% for females and 2.6 to 3%, 8% for boys is a relative rise 29% and smoking rates by 4.1%.  Conclusions: A few years apart national tobacco policies can make the best and the worst. Abandoning teenagers recently at their smoking policies hamper the future of a generation, and cutting back the significant benefits of the first cancer plan.
Abstract 611: Promoted Autologous Tissue Regeneration Using a Newly Developed Tissue-Engineered Small Caliber Vascular Graft without Cell Seeding
Authors: Takenori Yokota, Hajime Ichikawa, Goro Matsumiya, Toru Kuratani, Masayuki Sakaki, Yukitoshi Shirakawa, Katsukiyo Kitabayashi, Hiroaki Takahashi, Eiichi Kaku, Yoshiki Sawa
Journal: Circulation (2007)
Effects of a community-based health program assessed by spirometry and body composition
Authors: Ritsuko Wakabayashi, Hideki Matsuki, Keiko Shimizu, Tomoko Kutsuzawa
Journal: European Respiratory Journal (2013)

Background: Rapid aging of a population and change in lifestyles can cause an increase in chronic disease. Therefore, early diagnosis and treatment of chronic disease is important to improve QOL, reduce the cost of care and health services.  Objective: This study evaluates the effects of a community-based health program by measuring spiromety and body composition.  Methods: A health program consisting of 15 lectures on healthy living and 24 leisure sport classes (i.e. stretching, table tennis) over 1-year. Subjects over 40 years of age and residing in the community could participate. Spirometry and body composition was evaluated before the program and at 1-year follow up.  Results: Sixty-seven participants (male 21; female 46), with a mean age of 64.4±8.4, FEV1.0 of 2.3±0.5L and FEV1, %predict of 101.7±13.8% were included. Of the 67 subjects, 2 participants (3%) had an FEV1, %predict   Conclusion: This open program consisted of lectures and leisure sports without muscule training. There was no positive effect on spirometry or body composition and inevitably, a decline in pulmonary function was seen with age. This study reinforces the need for strength training focusing on upper and lower limbs to prevent a decline in pulmonary function.
The role of bone-marrow derived adult stem cells in asthmatic airway remodeling
Authors: Hai-Feng Ou-Yang, Chang-Gui Wu
Journal: European Respiratory Journal (2011)

Background and objective:  Asthmatic airway remodeling is an abnormal injury/repair process of small airway on the basis of chronic inflammation, in which the quantities of multiple lung parenchyma cells dramatically increase. However, the origin of these proliferative cells is still not clearly elucidated. The aim of the study is to examine whether BM-derived adult stem cells are responsible for the massive proliferative cells in asthmatic airway remodeling.   Methods:  Adult mice were durably engrafted with BM isolated from GFP transgenic mice. Using GFP BM-chimera mice, OVA-induced chronic asthma model were established. The distribution of BM-derived GFP +  cells in the lung of chronic asthma mice was detected by fluorescence microscopy. The phenotype of BM-derived GFP +  cells in the lung was analyzed by flow cytometry.   Results:  BM-chimera mice were successfully constructed, with no detectable radioactive inflammation observed. Using BM-chimera mice, we established a mouse model of chronic asthma characterized by significant increment of the thickness of airway subepithelial base membrane and smooth muscle layers. OVA treatment caused many GFP +  cells to appear in the sites of small airway inflammation. The extravascular localization of some GFP +  cells and their morphology was not consistent with leukocytes. Flow-cytometric analysis revealed a significant increase in Col I + GFP +  cells and a-SMA + GFP +  cells in OVA-treated GFP BM-chimera mice.   Conclusions:  Considerable Col I-producing cells and a-SMA-producing cells originated from bone marrow in the lung tissues of OVA-induced chronic asthma mice and bone-marrow derived adult stem cells are at least partly responsible for asthmatic airway remodeling.
Changing epidemiology of invasive pneumococcal disease following increased coverage with the heptavalent conjugate vaccine in Navarre, Spain
Authors: M. Guevara, A. Barricarte, A. Gil-Setas, J.J. García-Irure, X. Beristain, L. Torroba, A. Petit, M.E. Polo Vigas, A. Aguinaga, J. Castilla
Journal: Clinical Microbiology and Infection (2009)
Likelihood ratios of prognostic strategies in normotensive pulmonary embolism: A systematic review
Authors: Carlos Celis, Dario Londoño, Lisseth Marin
Journal: European Respiratory Journal (2013)

Non high risk pulmonary embolism (NHPE) has a 30 day mortality ranging from less than 2% to as high as 15%.

We searched MEDLINE, EMBASE and TripDatabase for studies that assessed the prognostic value of several strategies to predict 30 day mortality, in NHPE patients. Study selection and data extraction was performed independently by two authors; risk of bias, evaluated by the QUIPS tool, was low.

The use of biomarker combined with imaging or PESI, was the best strategy to predict 30 day mortality.

View this table:



A cost-effectiveness analysis is mandatory.
Physical Activity, the Compression of Morbidity, and the Health of the Elderly
Authors: James F Fries
Journal: Journal of the Royal Society of Medicine (1996)

The Compression of Morbidity hypothesis envisions a potential reduction of overall morbidity, and of health care costs, now heavily concentrated in the senior years, by compression of morbidity between an increasing age of onset of disability and the age of death, increasing perhaps more slowly 1,2 . For this scenario to be able to be widely achieved, largely through prevention of disease and disability, we need to identify variables which predict future ill health, modify these variables, and document the improvements in health that result 3 . Physical activity is perhaps the most obvious of the variables which might reduce overall lifetime morbidity.
Male Hospital in Dean Street: a last link with London Locks.
Authors: Denis Gibbs
Journal: Journal of the Royal Society of Medicine (2002)

Most of the medieval leper or lazar houses which were established on the fringes of towns and cities in England were redundant by the middle of the 15th century; some became derelict while new uses were found for others. On the northern approach to the City of London was a lazar house which was one of several run as outposts of St Bartholomew's Hospital; it became known as Kingsland Lock and was then ‘applied to no other use than for the entertainment and cure of such as have the venereal malady’. A sundial which once stood in the garden of Kingsland Lock (now the site of a pub at Dalston Junction) was inscribed Post voluptatem misericordia (compassion after pleasure). A lock hospital in Southwark had a similar origin, whereas the much larger London Lock Hospital, which was purpose built facing Green Park near Hyde Park Corner on land granted on a 95-year lease from the Grosvenor estate, owed its foundation in 1746 to the voluntary hospital movement. When the lease expired the Georgian building of the London Lock was demolished in favour of fashionable new houses. A new Lock Hospital was built on a site between Harrow Road and the Regent's Canal in Westbourne Green, adjoining which a workhouse and infirmary (later Paddington General Hospital) were also built. None of these buildings remain. In addition to the new Lock Hospital, centrally located facilities were necessary. A house was acquired in Dean Street in Soho and replaced in 1912 by a neo-Georgian building, designed by Alfred Saxton Snell with the words Male Hospital in the portico. It survives as the only architectural reminder in London of a former era lasting several centuries, when Lock Hospitals provided for patients with venereal diseases.
Circulation of West Nile virus lineage 1 and 2 during an outbreak in Italy
Authors: F. Magurano, M.E. Remoli, M. Baggieri, C. Fortuna, A. Marchi, C. Fiorentini, P. Bucci, E. Benedetti, M.G. Ciufolini, C. Rizzo, S. Piga, P. Salcuni, G. Rezza, L. Nicoletti
Journal: Clinical Microbiology and Infection (2012)
Autogenous Antibodies Against the Murine Mammary Tumor Virus in Strains of Mice With Low Incidences of Mammary Tumors
Authors: R Michalides, E Wagenaar, R Nusse
Journal: JNCI Journal of the National Cancer Institute (1979)

The radioimmunoprecipitation assay for the murine mammary tumor virus (MuMTV) was used to detect naturally occurring antibodies against MuMTV in 3 groups of highly inbred mouse strains. 1) Some strains had high incidences of mammary tumors, such as strains GR and C3H. Antibodies against MuMTV were detected in the sera of females of these strains at early ages. 2) Some mouse strains had low incidences of mammary tumors with an intermediate MuMTV expression, such as strains C3Hf, RIIIf, and BALB/c. Some females of these strains developed antibodies against MuMTV. Hormone treatment of these mice resulted in an increase in the proportion of mice carrying antibodies against MuMTV. 3) Some mouse strains were MuMTV-free, such as strains O20, C57BL, and Gr-Mtv2-. No antibodies against MuMTV were detected in the sera of these mice. However, antibodies against MuMTV appeared in the sera of these animals after hormone treatment. The presence of a natural humoral immunity toward MuMTV appeared to be related to the expression of MuMTV in the animals.
Lawsuit seeks access to data from hepatitis C drug trial
Authors: M. McCarthy
Journal: BMJ (2015)

Two health advocacy groups have filed suit to compel the US Food and Drug Administration to release clinical trial data submitted to the agency for the approval of the hepatitis C drugs sofosbuvir and sofosbuvir with ledipasvir. The plaintiffs also seek all FDA records relating to the clinical trials and correspondence between the agency and the US Department of Health and Human Services with companies developing the drugs.

The suit, which was brought by the Treatment Action Group, an HIV and AIDS advocacy group, and the Global Health Justice Partnership, an initiative of the Yale Law School and School of Public Health, was filed in US District Court District of Connecticut on 25 June.1

The plaintiffs contended that an independent review of the data was needed because both …