Remission of Polycythemia Vera after Surgical Cure of Acromegaly
Authors: Pascale Grellier
Journal: Annals of Internal Medicine (1996)

Brief Communications1 March 1996Remission of Polycythemia Vera after Surgical Cure of AcromegalyPascale Grellier, MD, Philippe Chanson, MD, Nicole Casadevall, MD, Sherry Abboud, MD, and Gilbert Schaison, MDPascale Grellier, MDFrom the Hopital Bicetre, Kremlin-Bicetre, France; the Hopital Raymond Poincare, Garches, France; and the University of Texas Health Science Center, San Antonio, Texas.Search for more papers by this author, Philippe Chanson, MDFrom the Hopital Bicetre, Kremlin-Bicetre, France; the Hopital Raymond Poincare, Garches, France; and the University of Texas Health Science Center, San Antonio, Texas.Search for more papers by this author, Nicole Casadevall, MDFrom the Hopital Bicetre, Kremlin-Bicetre, France; the Hopital Raymond Poincare, Garches, France; and the University of Texas Health Science Center, San Antonio, Texas.Search for more papers by this author, Sherry Abboud, MDFrom the Hopital Bicetre, Kremlin-Bicetre, France; the Hopital Raymond Poincare, Garches, France; and the University of Texas Health Science Center, San Antonio, Texas.Search for more papers by this author, and Gilbert Schaison, MDFrom the Hopital Bicetre, Kremlin-Bicetre, France; the Hopital Raymond Poincare, Garches, France; and the University of Texas Health Science Center, San Antonio, Texas.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-124-5-199603010-00006 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail Polycythemia can be classified as a secondary or primary disorder. Increased erythropoietin levels associated with decreased oxygen saturation or with release by certain tumors cause secondary polycythemia. Polycythemia vera is a myeloproliferative disease characterized by abnormal clonal proliferation of an early hematopoietic progenitor, which leads to hyperplasia of all myeloid lineage cells [1]. Diagnostic criteria include increased erythrocyte mass associated with either splenomegaly or increased leukocyte and platelet counts. The precise cause of the marked erythroid expansion observed in patients with polycythemia vera has been debated. Recent studies [2-6] have suggested that insulin-like growth factor 1 (IGF-1) may play a ...References1. Adamson JW, Fialkow PJ, Murphy S, Prchal JF, Steinmann L. Polycythemia vera: stem-cell and probable clonal origin of the disease. N Engl J Med. 1976; 295:913-6. Google Scholar2. Correa PN, Eskinazi D, Axelrad AA. Circulating erythroid progenitors in polycythemia vera are hypersensitive to insulin-like growth factor-1 in vitro: studies in an improved serum-free medium. Blood. 1994; 83:99-112. Google Scholar3. Claustres M, Chatelain P, Sultan C. Insulin-like growth factor 1 stimulates human erythroid colony formation in vitro. J Clin Endocrinol Metab. 1987; 65:78-82. Google Scholar4. Kurtz A, Zapf J, Eckardt KU, Clemons G, Froesch ER, Bauer C. Insulin-like growth factor 1 stimulates erythropoiesis in hypophysectomized rats. Proc Natl Acad Sci U S A. 1988; 85:7825-9. Google Scholar5. Ratajczak MZ, Kuczynsky WI, Onodera K, Moore J, Ratajczak J, Kregenow DA, et al. A reappraisal of the role of insulin-like growth factor 1 in the regulation of human hematopoiesis. J Clin Invest. 1994; 94:320-7. Google Scholar6. Muta K, Krantz SB, Bondurant MC, Wickrema A. Distinct roles of erythropoietin, insulin-like growth factor 1, and stem cell factor in the development of erythroid progenitor cells. J Clin Invest. 1994; 94:34-43. Google Scholar7. Valla D, Casadevall N, Lacombe G, Varet B, Goldwasser E, Franco D, et al. Primary myeloproliferative disorder and hepatic thrombosis. A prospective study of erythroid colony formation in vitro in 20 patients with Budd-Chiari syndrome. Ann Intern Med. 1985; 103:329-34. Google Scholar8. Lemoine F, Najman A, Baillou C, Stachowiak J, Boffa G, Aegerter P, et al. A prospective study of the value of bone marrow erythroid progenitor cultures in polycythemia. Blood. 1986; 68:996-1002. Google Scholar9. Strauch G, Lego A, Therain F, Bricaire H. Reversible plasma and red blood cell volumes increase in acromegaly. Acta Endocrinol (Copenh). 1977; 85:465-78. Google Scholar10. Chanson P, Timsit J, Masquet C, Warnet A, Guillausseau PJ, Birman P, et al. Cardiovascular effects of the somatostatin analog octreotide in acromegaly. Ann Intern Med. 1990; 113:921-5. Google Scholar11. Congote LF. Extraction of an erythrotropin-like factor from bovine serum albumin (Cohn fraction V). In Vitro Cell Dev Biol. 1987; 23:361-6. Google Scholar Author, Article, and Disclosure InformationAuthors: Pascale Grellier, MD; Philippe Chanson, MD; Nicole Casadevall, MD; Sherry Abboud, MD; Gilbert Schaison, MDAffiliations: From the Hopital Bicetre, Kremlin-Bicetre, France; the Hopital Raymond Poincare, Garches, France; and the University of Texas Health Science Center, San Antonio, Texas.Grant Support: In part by the Veterans Administration Medical Research Service and National Institutes of Health Grant AR42306.Corresponding Author: Gilbert Schaison, MD, Service d'Endocrinologie et des Maladies de la Reproduction Hopital Bicetre, 78, rue du General Leclerc, F-94275 Kremlin-Bicetre, France.Current Author Addresses: Drs. Grellier, Chanson, and Schaison: Service d'Endocrinologie et des Maladies de la Reproduction Hopital Bicetre, 78, rue du General Leclerc, F-94275 Kremlin-Bicetre, France. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byHypersomatotropism induced secondary polycythaemia leading to spontaneous pituitary apoplexy resulting in cure of acromegaly and remission of polycythaemia: ‘The virtuous circle’Co-Occurrence of Acromegaly and Hematological Disorders: A Myth or Common Pathogenic MechanismAcromegaly at diagnosis in 3173 patients from the Liège Acromegaly Survey (LAS) DatabasePolycythemia as rare secondary direct manifestation of acromegaly: management and single-centre epidemiological dataJanus kinase (JAK) 2 V617F mutation as the cause of primary thrombocythemia in acromegaly with severe visceromegaly and divergence between growth hormone and insulin-like growth factor-1 concentrations during the follow-up: causal or casual association?Erythropoietin levels in endocrinopathiesEthics of Risk Analysis and Regulatory Review: From Bio- to NanotechnologyA review of conflict of interest, competing interest, and bias for toxicologistsEndocrine Effects of Erythropoietin in Cancer PatientsGigantismNo evidence for an altered mRNA expression or protein level of haematopoietic cell phosphatase in CD34+ bone marrow progenitor cells or mature peripheral blood cells in polycythaemia veraInsulin-Like Growth Factor Binding Protein-1 Is Elevated in Patients With Polycythemia Vera and Stimulates Erythroid Burst Formation In Vitro 1 March 1996Volume 124, Issue 5Page: 495-496KeywordsAcromegalyBody weightBone marrowErythropoietinGrowth hormoneHematocritHemoglobinInsulin-like growth factorsPolycythemiaPolycythemia vera ePublished: 15 August 2000 Issue Published: 1 March 1996 Copyright & PermissionsCopyright © 1996 by American College of Physicians. 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