SULFATHIAZOLE IN THE TREATMENT OF PNEUMOCOCCUS PNEUMONIA
Authors: Verner B. Callomon, William E. Goodpastor
Journal: Annals of Internal Medicine (1940)

Article1 December 1940SULFATHIAZOLE IN THE TREATMENT OF PNEUMOCOCCUS PNEUMONIAVERNER B. CALLOMON, M.D., WILLIAM E. GOODPASTOR, M.D.VERNER B. CALLOMON, M.D.Search for more papers by this author, WILLIAM E. GOODPASTOR, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-14-6-1024 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptIn view of the remarkable therapeutic effects obtained with sulfanilamide and sulfapyridine it was to be expected that investigators would direct their efforts to the preparation of derivatives or modifications of these drugs which, while retaining their therapeutic activity, would be free of the undesirable side-effects so commonly encountered in their use. One of the products recently made available is sulfathiazole (2-sulfanilamidethiazole), which was independently synthesized by Fosbinder and Walter,1 and Lott and Bergeim.2Several reports on the pharmacology and experimental use of this drug in animals and man have recently been published. From these the following observations may be...References1. FOSBINDERWALTER RJLA: Sulfanilamido derivatives of heterocyclic amines, Jr. Am. Chem. Soc., 1939, lxi, 2032. CrossrefGoogle Scholar2. LOTTBERGEIM WAFH: Communications to the Editor: 2-(p-Aminobenzenesulphonamido) thiazole: a new chemotherapeutic agent, Jr. Am. Chem. Soc., 1939, lxi, 3593. CrossrefGoogle Scholar3. REINHOLDFLIPPINSCHWARTZ JGHFL: Observations on the pharmacology and toxicology of sulfathiazole in man, Am. Jr. Med. Sci., 1940, cxcix, 393. CrossrefGoogle Scholar4. LONG PH: Thiazole derivatives of sulfanilamide: sulfathiazole and sulfamethylthiazole, Jr. Am. Med. Assoc., 1940, cxiv, 870. Google Scholar5. VAN DYKEGREEPRAKEMCKEE HBROGCM: Observations on the toxicology of sulfathiazole and sulfapyridine, Proc. Soc. Exper. Biol. and Med., 1939, xlii, 410. CrossrefGoogle Scholar6. MCKEERAKEGREEPVAN DYKE CMGROHB: Therapeutic effect of sulfathiazole and sulfapyridine, Proc. Soc. Exper. Biol. and Med., 1939, xlii, 417. CrossrefGoogle Scholar7. COOPERGROSSLEWIS FBPM: Chemotherapeutic evaluation of sulfanilamide derivatives of heterocyclic amines, Proc. Soc. Exper. Biol. and Med., 1939, xlii, 421. CrossrefGoogle Scholar8. FLIPPINSCHWARTZROSE HFLSB: The comparative effectiveness and toxicity of sulfathiazole and sulfapyridine in pneumococcic pneumonia, ANN. INT. MED., 1940, xiii, 2038. Google Scholar9. RAKEVAN DYKECORWINMCKEEGREEP GHBWCCMRO: Pathological changes following prolonged administration of sulfathiazole and sulfapyridine, Jr. Bact., 1940, xxxix, 45. Google Scholar10. GROSSCOOPERSCOTT PFBRE: Urolithiasis medicamentosa, Urol. and Cut. Rev., 1940, xliv, 205. Google Scholar11. LONGHAVILANDEDWARDSBLISS PHJWLBEA: The toxic manifestations of sulfanilamide and its derivatives, Jr. Am. Med. Assoc., 1940, cxv, 364. CrossrefGoogle Scholar12. ARNETT JH: Hematuria from sulfathiazole therapy in pneumonia, Jr. Am. Med. Assoc., 1940, cxv, 362. CrossrefGoogle Scholar13. PEPPERHORACK DSHM: Crystalline concretions in the renal tubules following sulfathiazole therapy: widely patent foramen ovale in a patient aged 77, Am. Jr. Med. Sci., 1940, cxcix, 674. CrossrefGoogle Scholar14. CALLOMON VB: Treatment of pneumonia with type-specific immune rabbit serum, Am. Jr. Med. Sci., 1939, cxcviii, 349. CrossrefGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Pittsburgh, Pennsylvania*Received for publication August 12, 1940.From the Department of Respiratory Diseases, Medical Division, Allegheny General Hospital, and the Department of Respiratory Diseases, Montefiore Hospital, Pittsburgh, Pa.The sulfathiazole used in this study was furnished by E. R. Squibb & Sons, New York. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byEarly Modern Stone DiseasePNEUMONIA TREATED WITH SULPHA- PYRIDINE AND SULPHATHIAZOLE CONCENTRATION OF THE DRUGS IN THE BLOODSulfathiazol and sulfamethylthiazol in the treatment of pneumoniaCommunicable Diseases and Military Medicine 1 December 1940Volume 14, Issue 6Page: 1024-1031KeywordsDrug synthesisDrugsPharmacologyPneumococcusPneumoniaPulmonary diseases ePublished: 1 December 2008 Issue Published: 1 December 1940 PDF downloadLoading ...