THE RENAL THRESHOLD FOR GLUCOSE; CLINICAL OBSERVATIONS ON A CASE OF NON-DIABETIC (RENAL) GLYCOSURIA
Authors: Henry M. Thomas, Hamilton Southworth
Journal: Annals of Internal Medicine (1939)

Article1 April 1939THE RENAL THRESHOLD FOR GLUCOSE; CLINICAL OBSERVATIONS ON A CASE OF NON-DIABETIC (RENAL) GLYCOSURIAHENRY M. THOMAS JR., F.A.C.P., HAMILTON SOUTHWORTHHENRY M. THOMAS JR., F.A.C.P.Search for more papers by this author, HAMILTON SOUTHWORTHSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-12-10-1560 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe present day conception of the functional activity of the renal unit has changed the views of the clinician in regard to renal threshold for glucose. It is now believed that the glucose content of glomerular fluid approximates that of the plasma of arterial blood and that in a normal kidney under ordinary conditions, practically all of the glucose is reabsorbed in the first portion of the tubule. The so-called renal threshold is measured in terms of the level of blood sugar at which sugar appears in the urine. Actually, it depends entirely on the functional ability, at any given...Bibliography1. LEWISMOSENTHAL DSHO: Renal diabetes, Bull. Johns Hopkins Hosp., 1916, xxvii, 133. Google Scholar2. ALLANVANZANT FNFR: Renal glycosuria with ketosis during surgical complications, Am. Jr. Med. Sci., 1930, clxxx, 670. CrossrefGoogle Scholar3. JOSLIN EP: The treatment of diabetes mellitus, Sixth Edition, 1937, Lea and Febiger, Philadelphia. Google Scholar4. FALTA W: Renal and insular diabetes, Wien. klin. Wchnschr., 1929; Med. Jr. and Rec., 1930, cxxi, 335. Urban & Schwarzenberg, Berlin, 1930. Google Scholar5. POULSSON LT: On the mechanism of sugar elimination in phlorrhizin glycosuria. A contribution to the filtration-reabsorption theory on kidney function, Jr. Physiol., 1930, lxix, 411. CrossrefGoogle Scholar6. BURGESSHARVEYMARSHALL WWAMEK: The site of the antidiuretic action of pituitary extract, Jr. Pharm. and Exper. Therap., 1933, xlix, 237. Google Scholar7. SHANNONSMITH JAHW: The excretion of inulin, xylose and urea by normal and phlorhizinized man, Jr. Clin. Invest., 1935, xlv, 393. CrossrefGoogle Scholar8. PALMERLADD WWWS: The carbohydrate-fat ratio in relation to the production of ketone bodies in diabetes mellitus, Proc. Soc. Exper. Biol. and Med., 1921, xviii, 109. Google Scholar9. FISCHER AE: Intermittent and continuous renal glycosuria, Am. Jr. Dis. Child., 1935, l, 166. CrossrefGoogle Scholar10. ROCHMARTINSCICLOUNOFF MEF: Les rapports entre la glycemie et la glycosurie, Acta med. Scandinav., 1936, lxxxviii, 1. Google Scholar11. FOWLER AF: Renal glycosuria, ANN. INT. MED., 1933, vii, 518. Google Scholar12. CAMPBELLOSGOODHASKINS RAEEHD: Normal renal threshold for dextrose, Arch. Int. Med., 1932, l, 952. CrossrefGoogle Scholar13. ROBINSONDERIVAUXHEWELL CSRCB: Factors affecting the appearance and duration of glycosuria, Am. Jr. Med. Sci., 1935, clxxxix, 795. CrossrefGoogle Scholar14. HAMMANHIRSCHMAN LII: Studies on blood sugar, Arch. Int. Med., 1917, xx, 761. CrossrefGoogle Scholar15. OLMSTED JM: Changes in the permeability of red corpuscles in shed blood to glucose, Am. Jr. Physiol., 1935-36, cxiv, 488-490. CrossrefGoogle Scholar16. FABER K: Benign glycosuria due to disturbance in the blood sugar regulating mechanism, Jr. Clin. Invest., 1926, iii, 203. CrossrefGoogle Scholar17. PILLMAN WILLIAMSWILLS ECL: Studies in blood and urinary chemistry during pregnancy, Quart. Jr. Med., 1928-29, xxii, 493. Google Scholar18. CORI GT: Personal communication, 1937. Google Scholar19. SKIPPER E: Diabetes mellitus in pregnancy, Quart. Jr. Med., 1933, ii, 353. Google Scholar20. BERGLUND : The kidney in health and disease, 1935, Lea and Febiger, Philadelphia. CrossrefGoogle Scholar21. RICHARDS AN: Urine formation in the amphibian kidney. (See reference 20, p. 295.) Google Scholar22. RICHARDSWEARN ANJT: The concentration of chlorides in the glomerular urine of frogs, Jr. Biol. Chem., 1925, lxvi, 247. Google Scholar23. NIREHBERG TPB: On the mechanism of sugar excretion. I. Glucose, Biochem. Jr., 1930, xxiv, 1039. CrossrefGoogle Scholar24. SMITH HW: Physiology of the kidney, 1937, Oxford University Press, N. Y. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Baltimore, Maryland*Received for publication March 8, 1938.From the Medical Clinic of the Johns Hopkins Hospital. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byKrankheiten des KohlenhydratstoffwechselsRenal glycosuria 1 April 1939Volume 12, Issue 10Page: 1560-1575KeywordsBlood plasmaBlood sugarGlucoseHospitalsKidneysUrine Issue Published: 1 April 1939 PDF downloadLoading ...