tbuckley/cabot-search huggingface dataset:
Intradermal influenza vaccine using Portojet 1976.
Authors: D K Payler
Journal: BMJ (1977)

ruling out the presence of bony secondaries, confirming the indication for primary surgical treatment.Whole-body bone scanning is easy to perform, non-invasive in nature, takes 30 minutes of the patient's time, and costs approximately £6.It should be routinely performed in the staging of carcinoma of the bronchus.
Imaging of cardiac allograft rejection in dogs using indium-111 monoclonal antimyosin Fab
Authors: Linda J. Addonizio, Robert E. Michler, Charles Marboe, Peter E. Esser, Lynne L. Johnson, David W. Seldin, Welton M. Gersony, Philip O. Alderson, Eric A. Rose, Paul J. Cannon
Journal: Journal of the American College of Cardiology (1987)
The Gift from the Poor to the Rich
Authors: ANGELO TARANTA
Journal: Annals of Internal Medicine (1973)

Editorial Notes1 February 1973The Gift from the Poor to the RichANGELO TARANTA, M.D.ANGELO TARANTA, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-78-2-299 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptIn September 1970 scientists, physicians, and educators were convened in Geneva by the Council for International Organizations of Medical Sciences to discuss, besides the training of medical research workers indicated in the round table's title, the brain drain of medical scientists: the proceedings have now been published (1). Underlying assumptions were that the training should be improved and that the drain should be reduced. By the end of the conference, the participants had adopted no resolutions, nor formulated any conclusion, but they had had some interesting discussions.Should practitioners and researchers go to the same school? If they do, they...Reference1. Training of Research Workers in the Medical Sciences. Proceedings of a Round Table Conference organized by the Council for International Organizations of Medical Sciences. Geneva, the World Health Organization, 1972 Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: New York University Medical Center New York, N.Y. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 February 1973Volume 78, Issue 2Page: 299-299KeywordsBrainScientists ePublished: 1 December 2008 Issue Published: 1 February 1973 PDF downloadLoading ...
Near Neutrality, Rate Heterogeneity, and Linkage Govern Mitochondrial Genome Evolution in Atlantic Cod (Gadus morhua) and Other Gadine Fish
Authors: H. D. Marshall, M. W. Coulson, S. M. Carr
Journal: Molecular Biology and Evolution (2008)

The mitochondrial DNA (mtDNA) genome figures prominently in evolutionary investigations of vertebrate animals due to a suite of characteristics that include absence of Darwinian selection, high mutation rate, and inheritance as a single linkage group. Given complete linkage and selective neutrality, mtDNA gene trees are expected to correspond to intraspecific phylogenies, and mtDNA diversity will reflect population size. The validity of these assumptions is, however, rarely tested on a genome-wide scale. Here, we analyze rates and patterns of molecular evolution among 32 whole mitochondrial genomes of Atlantic Cod (Gadus morhua) as compared with its sister taxon, the walleye pollock (Gadus [Theragra] chalcogrammus), and genomes of seven other gadine codfish. We evaluate selection within G. morhua, between sister species, and among species and intraspecific measures of linkage disequilibrium and recombination within G. morhua. Strong rate heterogeneity occurs among sites and genes at all levels of hierarchical comparison, consistent with variation in mutation rates across the genome. Neutrality indices (dN/dS) are significantly greater than unity among G. morhua genomes and between sister species, which suggests that polymorphisms within species are slightly deleterious, as expected under the nearly neutral theory of molecular evolution. Among species of gadines, dN/dS ratios are heterogeneous among genes, consistent with purifying selection and variation in functional constraint among genes rather than positive selection. The dN/dS ratio for ND4L is anomalously high across all hierarchical levels. There is no evidence for recombination within G. morhua. These patterns contrast strongly with those reported for humans: genome-wide patterns in other vertebrates should be investigated to elucidate the complex patterns of mtDNA molecular evolution.
Zimbabwe's health system is now in a state of collapse
Authors: K. Adams
Journal: BMJ (2008)

A year is not long in the death of a nation, but I was stunned by how much Zimbabwe had changed in the past 12 months. The healthcare system is in a state of collapse. The whole country is being destroyed.

Zimbabweans stoically put up with the extreme living difficulties caused by their government’s policies and its mismanagement of the economy. Since my last visit a year ago ( BMJ 2008;336:98, doi:10.1136/bmj.39450.635579.0F) 10 zeroes have been taken off the currency, inflation has reached 231 000 000%, and chronic food shortages and daily power cuts continue.

How bad do things need to get? Why don’t people collectively stand up against the regime that has wrecked this beautiful and once functioning country? People are tired, hungry, scared, and oppressed. The violence perpetrated by the followers of Robert Mugabe and Zanu PF remains fresh in people’s minds.

As I leave Zimbabwe, Bulawayo’s health department is preparing for an expected cholera outbreak. There is cholera in Harare and other places in Zimbabwe, a sign that the public infrastructure is really breaking down.

Last week nurses and junior …
Störungen im Arbeitsverhalten Jugendlicher
Authors: A.M. Becker
Journal: Psychotherapy and Psychosomatics (1959)

Review Articles| February 10 2010 Störungen im Arbeitsverhalten Jugendlicher Subject Area: Psychiatry and Psychology A.M. Becker A.M. Becker Aus der Psychiatrisch·Neurologischen Universitätsklinik Wien (Vorstand: Prof. Dr. H. Hoff) und dem Jugendambulatorium der Wiener Gebietskrankenkasse (Psychotherapeutische Ambulanz: Dr. A. M. Becker) Search for other works by this author on: This Site PubMed Google Scholar Acta Psychotherapeutica et Psychosomatica (1959) 7 (1): 23–35. https://doi.org/10.1159/000285363 Article history Published Online: February 10 2010 Content Tools Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Facebook Twitter LinkedIn Email Tools Icon Tools Get Permissions Cite Icon Cite Search Site Citation A.M. Becker; Störungen im Arbeitsverhalten Jugendlicher. Acta Psychotherapeutica et Psychosomatica 1 January 1959; 7 (1): 23–35. https://doi.org/10.1159/000285363 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAll JournalsActa Psychotherapeutica et Psychosomatica Search Advanced Search Article PDF first page preview Close Modal This content is only available via PDF. 1959Copyright / Drug Dosage / DisclaimerCopyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher.Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. You do not currently have access to this content.
Sensitization to blackgram in patients with bronchial asthma and rhinitis: clinical evaluation and characterization of allergens
Authors: D. Kumari, R. Kumar, S. Sridhara, N. Arora, S. N. Gaur, B. P. Singh
Journal: Allergy (2005)

Background: Legumes are important causative agents of type I hypersensitivity in south Asia and Europe but such studies are lacking in Indian population. The present study investigates blackgram sensitization in asthma and rhinitis patients and identifies immunoglobulin E (IgE)‐binding proteins. Methods: Respiratory allergy patients were evaluated using standard questionnaire and skin prick tests (SPT) with common foods and aeroallergens. Blackgram‐specific IgE level was estimated by enzyme‐linked immunosorbent assay (ELISA) and sensitization was established by a double‐blind, placebo‐controlled food challenge (DBPCFC). The cross‐reactivity of blackgram with other legumes was studied by immunobiochemical methods. Result: Of 816 patients, 35 gave history of blackgram hypersensitivity. From these, 16 patients were SPT positive and 14 showed elevated specific IgE (three times of negative control) to blackgram. DBPCFC established blackgram sensitivity in four of 14 patients. Immunoblotting with individual patient's sera recognized eight most prevalent allergens of 78, 56, 47, 43, 40, 30, 28 and 16 kDa. Roasted blackgram showed six major allergens whereas 47, 43 and 28 kDa proteins retained IgE reactivity upon boiling. Blackgram extract required 14 ng of self protein for 50% ELISA inhibition whereas roasted and boiled blackgram required 16 and 120 ng protein. ELISA and immunoblot inhibition show partial inhibition to blackgram proteins by lentil, limabean and pea. Conclusion: Blackgram induces IgE‐mediated reactions in 1.7% of asthma and rhinitis patients and contains eight major IgE‐binding components, of which six retained IgE reactivity after roasting. Blackgram shares allergenicity with lentil and limabean.
Estimation of the Healthy Upper Limits for Serum Alanine Aminotransferase in Asian Populations With Normal Liver Histology
Authors: Jae Keun Lee, Ju Hyun Shim, Han Chu Lee, Sae Hwan Lee, Kang Mo Kim, Young-Suk Lim, Young-Hwa Chung, Yung Sang Lee, Dong Jin Suh
Journal: Hepatology (2009)

A recent study in young Italian subjects suggested that the healthy thresholds for serum alanine aminotransferase (ALT) levels should be adjusted to 30 IU/L for men and 19 IU/L for women when assessing risk factors for nonalcoholic fatty liver disease. Our aim was to assess serum ALT concentrations in healthy Korean individuals and to determine the factors affecting ALT levels in these populations. We included 1,105 potential liver donors (643 men and 462 women) with biopsy-proven normal livers. Median ages were 25 years in men and 30 years in women, with a median body mass index (BMI) of 22.3 kg/m2 in men and 21.4 kg/m2 in women. The calculated thresholds for ALT values in these subjects were 35 IU/L for men and 26 IU/L for women. Age and BMI were independently correlated with ALT levels in both sexes, whereas serum total cholesterol concentration was significant only in men and blood glucose level only in women ( P &lt; 0.05). When we chose a subgroup of 665 individuals (346 men and 319 women) using Prati criteria, modified by the BMI cutoff points for Asians (&lt;23 kg/m2), we found that the healthy ALT values were 33 IU/L for men and 25 IU/L for women. The mean ALT concentrations for subjects within the Prati criteria were significantly lower than for those outside the criteria (16.7 versus 19.5 IU/L for men, 12.8 versus 14.9 IU/L for women; P &lt; 0.001). Conclusion: The healthy ALT thresholds in biopsy-proven normal Asians were clearly lower than the previously accepted thresholds, as has also been noted in Europeans. Age, BMI, and/or other metabolic parameters significantly affect ALT levels, even in subjects with normal livers. (Hepatology 2010.)
Functional pathway mapping of human glioblastoma multiforme and brain metastases for patient tailored therapy
Authors: M. Khalil, J. Wulfkuhle, H. Fillmore, J. Deng, L. Liotta, E. Petricoin, J. Watson, W. Broaddus
Journal: Journal of Clinical Oncology (2009)

2076 Background: Genome scanning analysis of human glioblastoma multiforme (GBM) has suggested that this form of cancer is a protein pathway disease. Since genomic analysis cannot directly predict protein activation, analysis of protein pathway activation is required. With the current focus on targeted translational therapeutic modalities, a functional understanding of the GBM signaling repertoire is critical, and yet largely unknown. Methods: Twelve tumors were included in this study: 10 GBMs (9 primary, 1 recurrent) and two brain metastases (1 breast and 1 lung). Pure tumor cell populations were obtained from fixed frozen tissue sections using Laser Capture Microdissection. Protein pathway mapping was performed using Reverse Phase Protein Microarrays (RPMA) whereby the activation of 85 key signaling proteins was quantitatively measured at once. Unsupervised and supervised analysis was used to explore pathway activation. Results: Unsupervised hierarchical clustering of all tumors in the study set revealed largely patient-specific signaling portraits yet also identified distinct pathway subsets. The two metastatic tumors clustered separately and distinctly from the GBMs. The GBM specimens clustered according to pathway activity. Statistical analysis demonstrated significant correlations between certain phosphorylated endpoints detected and overall survival. Phosphorylation of cofilin (S3) was associated with shorter survival time, while Stat1 (Y701) and Shc (Y317) phosphorylation were both positively correlated with longer overall survival. Conclusions: This study represents the most comprehensive proteomic analysis of human GBM pathway mapping to date. Since certain pathway biomarkers are themselves being targeted by current investigational therapies, the ability to map pathway activation and identify critical pathway biomarkers can lead to targeted therapeutics tailored to each patient's tumor. The ability to segregate short from long-term survivors according to protein pathway activation is promising. [Table: see text]
Ethnic Variation in Response to Alcohol
Authors: Tamara L. Wall
Journal: Annals of Internal Medicine (1998)

Letters15 March 1998Ethnic Variation in Response to AlcoholTamara L. Wall, PhDTamara L. Wall, PhDUniversity of California, San Diego, School of Medicine; San Diego, CA 92093Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-128-6-199803150-00023 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:I appreciate Dr. Shriver's insightful editorial on ethnic variation as a key to the biology of human disease [1]. His comments provide an important context for understanding the assets and limitations of studying within ethnic variability to increase knowledge of complex diseases such as alcoholism [2]. I completely agree with Dr. Shriver's general comments but want to clarify one point. He stated that my colleagues and I “address the mechanism underlying the unpleasant sensations and facial flush experienced by many Asian persons after the consumption of alcohol.” In 1974, Ewing and colleagues were the first to relate ...References1. Shriver MD. Ethnic variation as a key to the biology of human disease [Editorial]. Ann Intern Med. 1997; 127:401-3. Google Scholar2. Wall TL, Peterson CM, Peterson KP, Johnson ML, Thomasson HR, Cole M, et al. Alcohol metabolism in Asian-American men with genetic polymorphisms of aldehyde dehydrogenase. Ann Intern Med. 1997; 127:376-9. Google Scholar3. Ewing JA, Rouse BA, Pellizzari ED. Alcohol sensitivity and ethnic background. Am J Psychiatr. 1974; 131:206-10. Google Scholar4. Wall TL, Thomasson HR, Schuckit MA, Ehlers CL. Subjective feelings of alcohol intoxication in Asians with genetic variations of ALDH2 alleles. Alcoholism: Clinical and Experimental Research. 1992; 16:991-5. Google Scholar5. Higuchi S, Matsushita S, Murayama M, Takagi T, Hayashida M. Alcohol and aldehyde dehydrogenase polymorphisms and the risk for alcoholism. Am J Psychiatr. 1995; 152:1219-21. Google Scholar Author, Article, and Disclosure InformationAuthors: Tamara L. Wall, PhDAffiliations: University of California, San Diego, School of Medicine; San Diego, CA 92093 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 15 March 1998Volume 128, Issue 6Page: 507KeywordsAlcoholismAlcoholsAllelesBloodDehydrogenasesEmotionsGeneticsIngestionIntoxicationMutation ePublished: 15 August 2000 Issue Published: 15 March 1998 Copyright & PermissionsCopyright © 1998 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Vaccine preservative is not the cause of autism, say US officials
Authors: Jeanne Lenzer
Journal: BMJ (2005)

Thiomersal, a mercury containing preservative used in children's vaccines known in the US as Thimerosal, is not the cause of autism, said top officials from key US government agencies at a joint news conference on 19 July.

The announcement, held one day before a rally sponsored by 11 autism groups in Washington, DC, caused a fierce reaction among parents' groups and several politicians, who criticised the government's claims as politically motivated and aimed, in part, at deterring product liability suits against makers of the vaccines.

The conference was held jointly by the Centers for Disease Control and Prevention (CDC), the National Institute of Child Health Development, and the Food and Drug Administration. Julie Gerberding, director of the CDC, said the briefing was held because of concerns that unwarranted fear of vaccination could lead to the re-emergence of …
Acquired ichthyosis and impaired dermal lipogenesis in Hodgkin's disease
Authors: MARY F. COOPER, P. D. WILSON, P. J. HARTOP, SAM SHUSTER
Journal: British Journal of Dermatology (1980)

Epidermal lipid biosynthesis was normal in patients with mild ichthyosis due to Hodgkin's disease, but greatly reduced in one patient with severe ichthyosis. Dermal (sebaceous) lipid synthesis was decreased in all patients with Hodgkin's disease, whether or not they had ichthyosis, and was greatly reduced in the patient with severe ichthyosis. Neither the mechanism nor the possible relationship between the dermal and epidermal changes is understood.
The Implications of Sleep Disturbance Epidemiology
Authors: Charles F. Reynolds
Journal: JAMA (1989)

The article by Ford and Kamerow<sup>1</sup>in this issue ofThe Journalhas implications for clinicians, epidemiologists, and policymakers in the area of health care utilization and planning. Using a household probability sample,<sup>2</sup>a conservative definition of sleep complaints, structured psychiatric interviewing, systematic follow-up, and logistic regression modeling, this is probably one of the most scientifically rigorous epidemiologic investigations of sleep disturbance and psychopathology ever reported. A surprising result is the high prevalence of psychiatric disorders among respondents complaining of hypersomnia or excessive daytime sleepiness, variously 45.6% to 64%. Over the past quarter-century, most studies of excessive daytime sleepiness, which have been based on treatment-prevalence data (rather than on a household probability sample, as in the article by Ford and Kamerow), have noted the strong association of excessive daytime sleepiness with sleep apnea and narcolepsy-cataplexy but not with psychiatric disorders (see, for example, Coleman et al<sup>3</sup>). Thus,
RELATIONSHIPS BETWEEN SYSTOLIC BLOOD PRESSURE AND CARDIOVASCULAR OUTCOMES IN PATIENTS WITH HIGH RISK HYPERTENSION: AN ANALYSIS OF THE ACCOMPLISH TRIAL
Authors: Michael A. Weber, George Bakris, Allen Hester, Matthew Weir, Tsushung Hua, Dion Zappe, Bjorn Dahlof, Eric Velazquez, Bertram Pitt, Kenneth Jamerson
Journal: Journal of the American College of Cardiology (2013)
Coronary Artery Embolism and Myocardial Infarction
Authors: KATE ROTHKO PRIZEL
Journal: Annals of Internal Medicine (1978)

Although coronary artery embolism is a recognized entity, there is little morphologic information indicating it is a cause of myocardial infarction. We studied patients with coronary artery embolic infarcts, which comprised 13% of our autopsy-studied infarcts. Underlying diseases predisposing to coronary emboli included valvular heart disease (40%), myocardiopathy (29%), coronary atherosclerosis (16%), and chronic atrial fibrillation (24%). Mural thrombi were present in 18 (33%). Myocardial infarction, clinically diagnosed in 15 (27%) patients, caused death in 11 (20%). Most emboli involved the left coronary artery and lodged distally, causing infarcts that were usually transmural. Because of their distal location and recanalization, coronary emboli may be a cause of infarcts with angiographically normal coronaries. Thus, coronary emboli are not rare, may produce signs and symptoms indistinguishable from atherosclerotic coronary disease, and by lodging distally in coronary arteries that are usually previously normal, they most often cause small but transmural myocardial infarction.
Disseminated HPV Following Stem Cell Transplant (SCT) in NK(-) Severe Combined Immune Deficiency (SCID) and Association with NK Cell Dysfunction
Authors: Kapil Saxena, Sarah K. Nicholas, Pinaki Banerjee, Filiz Seeborg, Theresa Wright, Caridad Martinez, Jordan Orange, I. Celine Hanson
Journal: Journal of Allergy and Clinical Immunology (2013)
Industry funding of patients' support groups: Objectives of patients, clinicians, and industry are similar
Authors: P. M Lapsley
Journal: BMJ (2003)

EDITOR—As the British umbrella organisation representing the interests of all people with skin diseases and their patients' groups, the Skin Care Campaign welcomed the balanced approach taken by Herxheimer in his article on the relationship between the pharmaceutical industry and patients' organisations.1 However, we contest the argument that industry will if nothing else influence policy if it directly …