tbuckley/cabot-search huggingface dataset:
Fungal Contamination of Tobacco and Marijuana
Authors: Paul E. Verweij
Journal: JAMA (2000)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Traumatic Spinal Cord Injury in the United States, 1993-2012
Authors: Nitin B. Jain, Gregory D. Ayers, Emily N. Peterson, Mitchel B. Harris, Leslie Morse, Kevin C. O’Connor, Eric Garshick
Journal: JAMA (2015)

<h3>Importance</h3> Acute traumatic spinal cord injury results in disability and use of health care resources, yet data on contemporary national trends of traumatic spinal cord injury incidence and etiology are limited. <h3>Objective</h3> To assess trends in acute traumatic spinal cord injury incidence, etiology, mortality, and associated surgical procedures in the United States from 1993 to 2012. <h3>Design, Setting, and Participants</h3> Analysis of survey data from the US Nationwide Inpatient Sample databases for 1993-2012, including a total of 63 109 patients with acute traumatic spinal cord injury. <h3>Main Outcomes and Measures</h3> Age- and sex-stratified incidence of acute traumatic spinal cord injury; trends in etiology and in-hospital mortality of acute traumatic spinal cord injury. <h3>Results</h3> In 1993, the estimated incidence of acute spinal cord injury was 53 cases (95% CI, 52-54 cases) per 1 million persons based on 2659 actual cases. In 2012, the estimated incidence was 54 cases (95% CI, 53-55 cases) per 1 million population based on 3393 cases (average annual percentage change, 0.2%; 95% CI, −0.5% to 0.9%). Incidence rates among the younger male population declined from 1993 to 2012: for age 16 to 24 years, from 144 cases/million (2405 cases) to 87 cases/million (1770 cases) (average annual percentage change, −2.5%; 95% CI, −3.3% to −1.8%); for age 25 to 44 years, from 96 cases/million (3959 cases) to 71 cases/million persons (2930 cases), (average annual percentage change, −1.2%; 95% CI, −2.1% to −0.3%). A high rate of increase was observed in men aged 65 to 74 years (from 84 cases/million in 1993 [695 cases] to 131 cases/million [1465 cases]; average annual percentage change, 2.7%; 95% CI, 2.0%-3.5%). The percentage of spinal cord injury associated with falls increased significantly from 28% (95% CI, 26%-30%) in 1997-2000 to 66% (95% CI, 64%-68%) in 2010-2012 in those aged 65 years or older (<i>P</i> &lt; .001). Although overall in-hospital mortality increased from 6.6% (95% CI, 6.1%-7.0%) in 1993-1996 to 7.5% (95% CI, 7.0%-8.0%) in 2010-2012 (<i>P</i> &lt; .001), mortality decreased significantly from 24.2% (95% CI, 19.7%-28.7%) in 1993-1996 to 20.1% (95% CI, 17.0%-23.2%) in 2010-2012 (<i>P</i> = .003) among persons aged 85 years or older. <h3>Conclusions and Relevance</h3> Between 1993 and 2012, the incidence rate of acute traumatic spinal cord injury remained relatively stable but, reflecting an increasing population, the total number of cases increased. The largest increase in incidence was observed in older patients, largely associated with an increase in falls, and in-hospital mortality remained high, especially among elderly persons.
Abstract 8783: Methylation of FOXP3 In Regulatory T Cells is Related to the Severity of Coronary Atherosclerosis
Authors: Lei Jia, Jizheng Wang, Xiaojian Wang, Jingzhou Chen, Channa Zhang, Rutai Hui
Journal: Circulation (2011)

Objective: Regulatory T (Treg) cells play a protective role in experimental atherosclerosis. However, the role of Treg in the development of human coronary artery disease (CAD) is inconsistent. Dem...
Stat5a/b contribute to interleukin 7–induced B-cell precursor expansion, but abl- andbcr/abl-induced transformation are independent of Stat5
Authors: Veronika Sexl, Roland Piekorz, Richard Moriggl, Juerg Rohrer, Michael P. Brown, Kevin D. Bunting, Kristen Rothammer, Martine F. Roussel, James N. Ihle
Journal: Blood (2000)
Positivity of patch tests in cutaneous reaction to diclofenac
Authors: A. Romano, F. Pietrantonio, M. Di Fonso, A. Garcovich, C. Chiarelli, A. Venuti, C. Barone
Journal: Allergy (1994)

Immune‐mediated reactions to NSAIDs are unusual. We have observed two cases of maculopapular eruptions occurring 48–72 h after administration of diclofenac sodium. Patch tests performed with diclofenac were positive. The histopathologic findings resembled those of contact dermatitis with different degrees of dermal involvement. Clinical, allergologic, and histopathologic patterns strongly suggest a type IV mechanism of hypersensitivity. Patch tests play an important role in the assessment of possible immunologic mechanisms underlying cutaneous reactions to drugs.
Abstract 19824: Percutaneous Mitral Balloon Comissurotomy versus Surgical Comissurotomy in the Treatment of Severe Symptomatic Mitral Stenosis
Authors: Rhanderson N Cardoso, Mohammad Ansari, Daniel Garcia, Eduardo De Marchena, Cesar E Mendoza
Journal: Circulation (2014)

Introduction: Percutaneous mitral balloon comissurotomy (PMBC) and surgical comissurotomy can be used for treatment of stage D mitral stenosis. Randomized controlled trials (RCTs) comparing PMBC and surgery have shown inconsistent results. Hypothesis: PMBC is associated with better hemodynamic and clinical results for the treatment of stage D mitral stenosis. Methods: Databases were searched for RCTs that compared double-balloon PMBC to surgical comissurotomy. Inclusion criteria were no left atrial clot, a favorable valve morphology and absence of significant mitral regurgitation. Clinical and hemodynamic outcomes were evaluated within short-term (less than 6 months) and long-term (over 6 months) follow up. Random-effects model was used due to anticipated heterogeneity. Results: A total of 6 RCTs with 474 patients were included, of whom 222 (46.8%) underwent PBMC. In short-term follow up, PMBC was associated with a larger mitral valve area (MVA) compared to surgical comissurotomy (mean difference 0.41 cm2; 95% CI 0.16-0.67; p=0.002; figure 1A), but also a higher incidence of moderate to severe mitral regurgitation (MR; OR 2.63; 95% CI 1.04-6.70; p=0.04; figure 1B). Short-term symptomatic (NYHA II-IV) heart failure (p=0.40) and new MR (p=0.32), as well as long-term MVA (p=0.23), restenosis (p=0.39), symptomatic heart failure (p=0.11), new MR (p=0.64) and need for reintervention (p=0.21) were not significantly different between groups. Conclusions: Our meta-analysis of RCTs suggests that PMBC is associated with an increased MVA as well as a higher incidence of moderate to severe MR when compared to surgery in the treatment of stage D MS. Therefore, the decision to proceed with PMBC or surgery in patients suitable for both procedures must rely on patient preferences, physician experience and risk of procedure-specific complications, such as left-to-right shunt with PMBC and wound infection/dehiscence with surgical comissurotomy.
Abstract 15497: Role of Hospital Performance on PCI Measures in Explaining Hospital Variation in 30-Day Risk-Standardized Mortality Rates
Authors: Philip W Chui, Craig Parzynski, Frederick A Masoudi, John C Messenger, Lara E Slattery, Jeptha P Curtis
Journal: Circulation (2014)

Introduction:  There is much interest in measuring and reporting the quality of care delivered by PCI hospitals. Both process and outcome measures represent potentially important indicators of hospital quality, but the extent to which hospital performance on process metrics correlates with variations in hospital PCI mortality is unknown. We examined the explained variance between hospitals’ performance on PCI process metrics and 30-day risk-standardized mortality rates (RSMR).   Methods:  We linked the NCDR CathPCI Registry with Medicare claims data for procedures performed from 2010-2011. We assessed hospital performance on PCI-related process measures (aspirin, thienopyridines, and statins on discharge; door-to-balloon time under ninety minutes; referral to cardiac rehabilitation; and a composite of all process metrics), and calculated hospitals’ RSMR using hierarchical linear modeling. Variance analyses were used to calculate the association between hospital performance on process metrics and 30-day RSMRs. Given the heterogeneity in PCI mortality by indication, rates were calculated separately in patients with a) STEMI or cardiogenic shock or b) neither STEMI nor cardiogenic shock.   Results:  The median 30-day RSMR was 12.1 for STEMI/Shock patients (interquartile range: 10.9-13.4) and 1.7 for No STEMI/No Shock patients (interquartile range: 1.6-2.0). Relatively little variation was seen in the discharge medication process metrics. Hospital performance on process measures only modestly explained the observed variation in 30-day RSMRs (Table). Individual process metrics explained between 0.5% and 2.3% of the variation in 30-day RSMR for STEMI/Shock patients and between 0.1% and 5.8% of the variation in No STEMI/No Shock patients.   Conclusion:  Hospital-level performance on PCI process measures explains only a small proportion of variations in RSMRs. Our findings suggest that PCI process and outcome measures represent distinct domains of quality.
Abstract 12749: Impact of Intrastent Yellow Plaque Observed by Coronary Angioscopy at Late Phase After Drug-Eluting Stents Implantation in Clinical Outcome
Authors: Kazuoki Dai, Takayuki Yamaji, Takafumi Oono, Yuuichi Morita, Haruki Hashimoto, Ayako Harima, Kuniomi Ooi, Toshiharu Oka, Yasuharu Nakama, Akinori Sairaku, Kenji Nishioka, Fumiharu Miura, Yuji Shimatani, Ichiro Inoue, Masaharu Ishihara
Journal: Circulation (2014)

Background: Previous study showed that number of yellow plaque in a coronary artery was associated with future risk of acute coronary syndrome. However, impact of intrastent yellow plaque has not fully understood. Purpose: This study was investigated to assess the association of the grade of intrastent yellow plaque observed by coronary angioscopy at late phase after drug-eluting stents (DES) implantation and clinical outcome. Methods: This study consisted of 97 patients tread with DES implantation (39 patients with sirolimus-eluting stents ; 9 patients with paclitaxel-eluting stents; 24 patients with everolimus-eluting stents; 6 patients with zotalolimus-eluting stents; 19 patients with biolimus-eluting stents ). Coronary angioscopy was performed 8 months after DES implantation. The plaque color at stent segment was grade as 0 (white), 1 (light yellow), 2 (yellow), 3 (bright yellow). The maximum color grade of the plaques in stent segment was assessed. We divided these patients into 2 groups (53 patients with yellow plaque grade 2 or 3; 44 patients with yellow plaque grade 0 or 1). We evaluated the incidence of revascularization, such as percutaneous coronary intervention or coronary artery bypass graft. Results: Kaplan-Meier curves for 7-year Revascularization free rate are shown in Figure. Revascularization free rate was tend to be higher in patients with yellow grade 0/1 than those with yellow grade 2/3. Conclusion: The presence of intrastent yellow plaque at late phase after stent implantation might be associated with the future revascularization in coronary artery disease.
Expression of an Antigen in Small Cell Lung Carcinoma Lines Detected by Antibodies from Patients with Paraneoplastic Dorsal Root Ganglionopathy
Authors: Corinna Budde-Steffen, Neil E. Anderson, Marc K. Rosenblum, Jerome B. Posner
Journal: Cancer Research (1988)

We have identified an autoantibody that reacts with a neuronal nucleoprotein in the serum of patients with small cell lung carcinoma (SCLC) and the paraneoplastic syndrome, subacute sensory neuronopathy (SSN). A similar antigen has been found in the tumor from one of these patients. To determine the distribution of this antigen, immunoblots of a homogenate from the SCLC of another patient with SSN, six SCLC cell lines from patients without SSN, five non-SCLC cell lines, and one ovarian carcinoma cell line were reacted with serum from five patients with SCLC and SSN. Control sera were obtained from two patients with SSN without cancer, two patients with SSN associated with tumors other than SCLC, two patients with paraneoplastic cerebellar degeneration, and five patients with SCLC but no SSN. The sera from all five patients with SCLC and SSN identified a Mr 35,000 to 40,000 antigen in neurons, in all of six SCLC cell lines and in the SCLC tumor homogenate. The antigen was not detected in other tumor cell lines. Control sera did not react with these bands, in either neurons or SCLC cell lines. Bound IgG was eluted from the blot of one SCLC cell line after reaction with SSN serum. Eluates from the Mr 35,000 to 40,000 area reacted with neuronal nuclei in the cerebral cortex by an immunoperoxidase technique; eluates from other areas of the blot were negative. These findings support the hypothesis that the autoantibody in SSN arises in reaction to an antigen shared between SCLC and neuronal nuclei.
Abstract A11: Adipocytes promote ovarian cancer cell survival in the presence of chemotherapeutic drugs
Authors: Jiang Yang, Monisha Sachdev, Marsha Moses
Journal: Clinical Cancer Research (2015)

Abstract Ovarian cancer cells, both primary and metastatic, reside in an environment rich in adipocytes. Adipocytes have been shown to promote ovarian cancer metastasis by secreting chemoattractant cytokines and to stimulate growth by directly transferring fatty acids into cancer cells. In addition to metastasis, another key reason for the high mortality rate among ovarian cancer patients is chemoresistance. Whether adipocytes have any effects on ovarian cancer chemoresistance remains unknown. To address this question, we isolated conditioned media from human adipocytes and found that the conditioned media increased ovarian cancer cell survival in the presence of chemotherapeutic drugs. We confirmed the protective effects of adipocytes using different human ovarian cancer cell lines (CAOV3, OVCAR5, OVCAR8 and SKOV3) and multiple chemotherapy drugs (cisplatin, paclitaxel and doxorubicin). Conditioned media dialyzed using a 10kDa cut-off membrane displayed the same protection against chemotherapy drugs, suggesting that proteins, not lipids, are more likely to mediate the pro-survival effects of adipocytes. Adiponectin and Leptin are two of the most upregulated proteins during adipocyte differentiation. However, inhibition of these two proteins, either through siRNA silencing or antibody neutralization, did not diminish the pro-survival effects of adipocytes. We also investigated the downstream signaling pathways and found that Akt was activated by adipocyte-conditioned media and was critical for adipocyte-induced effects given that treating ovarian cancer cells with Akt pathway inhibitor LY294002 abolished the pro-survival effects of the adipocytes. Taken together, these data demonstrate that secreted factors from adipocytes enhance the survival of ovarian cancer cells treated with chemotherapeutic drugs by activating the Akt pathway and suggest that adipocytes and associated factors may be important mediators of ovarian cancer chemoresistance. (This work is supported by the Weitzman Family Fund.) Citation Format: Jiang Yang, Monisha Sachdev, Marsha Moses. Adipocytes promote ovarian cancer cell survival in the presence of chemotherapeutic drugs. [abstract]. In: Proceedings of the AACR Precision Medicine Series: Drug Sensitivity and Resistance: Improving Cancer Therapy; Jun 18-21, 2014; Orlando, FL. Philadelphia (PA): AACR; Clin Cancer Res 2015;21(4 Suppl): Abstract nr A11.
SUBARACHNOID HEMORRHAGE SECONDARY TO A TUMOR OF THE HYPOPHYSIS WITH ACROMEGALY
Authors: J D KIRSHBAUM, B M CHAPMAN
Journal: Annals of Internal Medicine (1948)

Case Reports1 September 1948SUBARACHNOID HEMORRHAGE SECONDARY TO A TUMOR OF THE HYPOPHYSIS WITH ACROMEGALYJACK D. KIRSHBAUM, M.D., F.A.C.P., BERNARD M. CHAPMAN, M.D.JACK D. KIRSHBAUM, M.D., F.A.C.P., BERNARD M. CHAPMAN, M.D.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-29-3-536 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptCases of acromegaly are infrequently encountered and when seen are looked upon as curiosities. The clinical syndrome of acromegaly was first described in 1886 by Pierre Marie, and the following year Minkowski1 suggested that the disease was caused by derangement of the hypophysis cerebri. It is well known that acromegaly is associated with eosinophilic adenomas of the anterior lobe of the hypophysis. However, many cases of eosinophilic adenoma of the hypophysis do not manifest acromegalic features nor other endocrine disturbances clinically.Although most writers2state that acromegaly occurs usually between the ages of 20 and 30 years, the author's cases...Bibliography1. MINKOWSKI O: Arch. exper. Path. u. Pharmakol., 1893, xxxi, 85. CrossrefGoogle Scholar2. CUSHING H: The pituitary body and its diseases, 1912, J. B. Lippincott Co., Philadelphia. Google Scholar3. LEVY SS: Hyperpituitarism, Brit. Med. Jr., 1936, 931, 3935. Google Scholar4. BAILEY P: Intra-cranial tumors, 1933, Charles C. Thomas, Springfield, Illinois. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: *Received for publication November 16, 1945.This work was done prior to entry on active duty. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited bySubarachnoid Haemorrhage with Pituitary AdenomaPituitary Apoplexy Manifesting as Diffuse Subarachnoid Hemorrhage-Case Report-Differential DiagnosisAcromegaly presenting as subarachnoid haemorrhage in a 76 year old womanSpecial Problems Associated with Subarachnoid HemorrhageAcute hemorrhage into pituitary adenoma with SAH and anterior cerebral artery occlusionPituitary apoplexy: its incidence and clinical significancePituitary apoplexy (spontaneous pituitary necrosis)Meningitis as the presenting symptom of pituitary adenomataPituitary apoplexy: a review and reappraisalPituitary apoplexySPONTANEOUS NECROSIS IN PITUITARY TUMOURS (PITUITARY APOPLEXY)Acute Hemorrhage into Pituitary AdenomasDie Keimdrüsen und ihre KrankheitenVascular Lesions in Pituitary Adenomas 1 September 1948Volume 29, Issue 3Page: 536-540KeywordsAcromegalyAdenomasPituitary glandSubarachnoid hemorrhage ePublished: 1 December 2008 Issue Published: 1 September 1948 PDF downloadLoading ...
Somatic Hypermutation, Clonal Diversity, and Preferential Expression of the VH 51p1/VL kv325 Immunoglobulin Gene Combination in Hepatitis C Virus–Associated Immunocytomas
Authors: Martin Ivanovski, Federico Silvestri, Gabriele Pozzato, Shubha Anand, Cesare Mazzaro, Oscar R. Burrone, Dimitar G. Efremov
Journal: Blood (1998)
Rapid Change in Plaque Size, Composition, and Molecular Footprint After Recombinant Apolipoprotein A-IMilano (ETC-216) Administration
Authors: Borja Ibanez, Gemma Vilahur, Giovanni Cimmino, Walter S. Speidl, Antonio Pinero, Brian G. Choi, M. Urooj Zafar, Carlos G. Santos-Gallego, Brian Krause, Lina Badimon, Valentin Fuster, Juan J. Badimon
Journal: Journal of the American College of Cardiology (2008)
Reducing HIV Vertical Transmission Scrutinized
Authors: Joan Stephenson
Journal: JAMA (2005)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Late-breaking abstract: Possible association between vitamin D receptor SNP FokI and treatment response in asthmatic children
Authors: Helly Einisman, María Loreto Reyes, Marcelo Lopez-Lastra, Jenniffer Angulo, Marie Solange Caussade, Ana Moya, Jaime Cerda, Jose A. Castro-Rodriguez
Journal: European Respiratory Journal (2011)

Introduction:  An association between poor asthma control and low 25OH Vitamin D (25OHD) has been shown. Single nucleotide polymorphisms (SNP) in the gene encoding 25OHD receptor (VDR) have been associated with asthma. Hypothesis: asthma control is associated with 25OHD levels and VDR SNP.   Aims:  To compare 25OHD levels in controlled and uncontrolled asthmatic children and healthy controls; to genotype, in asthmatics, 2 SNP in the VDR gene.   Methods:  25OHD values in healthy children were obtained from a sample of a previous study. Asthmatics treated with at least 3 months of inhaled steroids were enrolled in outpatient clinics. A clinical questionnaire of asthma severity was applied and blood was drawn. 25OHD levels were measured with Radioinmunoasay and SNP were analyzed by a standar PCR-RFLP assay.   Results:  75 asthmatics (9.6+2.5 ys) and 226 healthy children (10.2+4.8 ys), were studied. 25OHD levels were 23.9+10.7 and 22.2+7.6 ng/ml respectively (p=0.122). No significant differences were found between controlled and uncontrolled asthmatics (24.96+11.1 and 21.55+7.3 ng/ml respectively). Analysis of FokI (rs10735810) SNP revealed that all patients (16/16) requiring GINA step 4 of treatment were heterozygous for the C allele. The presence of the C allele was less frequent in patients in step 2 (30/33) and 3 (16/24) (p=0.007). No significant differences in the other SNP (rs731236) and no association of neither SNP with asthma control status, were found.   Conclusions:  This pilot study established a possible association between FokI C allele and need of higher steroid doses for asthma control. VDR might play a role in asthma treatment response. Further research is required to validate it.