ANTERIOR PITUITARY INSUFFICIENCY (PANHYPOPITUITARISM—SIMMONDS' DISEASE), PITUITARY MYXEDEMA AND CONGESTIVE HEART FAILURE (MYXEDEMA HEART); REPORT OF CASE AND FINDINGS AT NECROPSY
Authors: H E CLUXTON, W A BENNETT, E J KEPLER
Journal: Annals of Internal Medicine (1948)

Case Reports1 October 1948ANTERIOR PITUITARY INSUFFICIENCY (PANHYPOPITUITARISM—SIMMONDS' DISEASE), PITUITARY MYXEDEMA AND CONGESTIVE HEART FAILURE (MYXEDEMA HEART); REPORT OF CASE AND FINDINGS AT NECROPSYHARLEY E. CLUXTON JR., M.D., WARREN A. BENNETT, M.D., EDWIN J. KEPLER, M.D., F.A.C.P.HARLEY E. CLUXTON JR., M.D.Search for more papers by this author, WARREN A. BENNETT, M.D.Search for more papers by this author, EDWIN J. KEPLER, M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-29-4-732 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptAnterior pituitary insufficiency (panhypopituitarism) may result from any pathologic process that destroys the anterior lobe. The most common lesion is the chromophobe tumor. Less frequently, other nonfunctioning neoplastic lesions, granulomas, chronic infections, atrophy, necrosis, hemorrhage, infarction or miscellaneous vascular disturbances account for pituitary failure. The terms "Simmonds' disease" and "Simmonds' cachexia"1have been applied, often indiscriminately, either to pituitary necrosis that occurs postpartum or to cachectic patients having, or thought to have, anterior pituitary insufficiency for other reasons. Clinically, the symptom complex that characterizes postpartum pituitary necrosis is essentially the same as that which occurs in conjunction with any other...Bibliography1. SIMMONDS M: Ueber Hypophysisschwund mit tödlichem Ausgang, Deutsch. med. Wchnschr., 1914, i, 322-323. CrossrefGoogle Scholar2. SHEEHAN HL: Post-partum necrosis of the anterior pituitary, Jr. Path. and Bact., 1937, xlv, 189-214. CrossrefGoogle Scholar3. MEANSHERTZLERMAN JHSJ: The pituitary type of myxedema or Simmonds' disease masquerading as myxedema, Trans. Assoc. Am. Phys., 1940, lv, 32-53. Google Scholar4. ZONDEK H: Das Myxödemherz, München. med. Wchnschr., 1918, ii, 1180-1182. Google Scholar5. ASSMANN H: Das Myxödemherz, München. med. Wchnschr., 1919, i, 9. Google Scholar6. MEISSNER R: Zur Klinik des Myxödemherzens, München. med. Wchnschr., 1920, ii, 1316-1317. Google Scholar7. FAHR G: Myxedema heart, Jr. Am. Med. Assoc., 1925, lxxxiv, 345-349. CrossrefGoogle Scholar8. MEANS JH: Thyroid and its diseases, 1937, J. B. Lippincott Company, Philadelphia, p. 243. Google Scholar9. MEANS JH: Thyroid and its diseases, 1937, J. B. Lippincott Company, Philadelphia, p. 250. Google Scholar10. MUSSIO FOURNIERCERVIÑOBAZZANO JCJMJJ: El aparato cardiovascular en las insuficiencias tiroideas. Manuales de medicina práctica, 1944, Salvat, Buenos Aires, pp. 81-111. Google Scholar11. LA DUE JS: Myxedema heart: a pathological and therapeutic study, Ann. Int. Med., 1943, xviii, 322-334. Google Scholar12. DARLEYGORDONNEUBUERGER WRWKT: Simmonds' disease with therapeutic response to hormone therapy for four years: report of a case with necropsy findings, Ann. Int. Med., 1944, xxi, 890-902. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Rochester, Minnesota*Received for publication January 13, 1947.From the Mayo Clinic, Rochester, Minnesota.†Deceased. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byElectrocardiographic changes in hypopituitarism of pregnancyDie NebennierePITUITARY MYXEDEMA: REPORT OF THREE CASES*H. ST. GEORGE TUCKER JR., M.D., JAMES L. CHITWOOD, M.D., CARL P. PARKER JR., M.D. 1 October 1948Volume 29, Issue 4Page: 732-745KeywordsAtrophyCardiovascular therapyGranulomasHeart diseasesHeart failureHemorrhageInfarctionLesionsNecrosisPanhypopituitarism ePublished: 1 December 2008 Issue Published: 1 October 1948 PDF downloadLoading ...