The Use of Potentially Nephrotoxic Antibiotics in the Treatment of Gram-negative Infections in Uremic Patients
Authors: NUZHET O. ATUK
Journal: Annals of Internal Medicine (1964)

Article1 January 1964The Use of Potentially Nephrotoxic Antibiotics in the Treatment of Gram-negative Infections in Uremic PatientsNUZHET O. ATUK, M.D., ALFON MOSCA, M.D., CALVIN KUNIN, M.D.NUZHET O. ATUK, M.D.Search for more papers by this author, ALFON MOSCA, M.D.Search for more papers by this author, CALVIN KUNIN, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-60-1-28 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptOne of the most troublesome complications of severe renal disease is infection (1, 2). Bacterial invasion of wounds, cut down sites, the lungs, and urinary tract appear to be poorly controlled by the uremic patient; infection may become disseminated and is frequently the cause of death. Gram-negative infections of the urinary tract are of particular concern since they may lead to further embarassment of already compromised renal function; in addition, bacterial endotoxin released from these organisms is capable of producing profound renal damage (3).Accordingly, many workers in this field have urged particular care toward the prevention of such infections...References1. BLUEMLEWEBSTERELKINTON LWGDJR: Acute tubular necrosis: analysis of one hundred cases with respect to mortality, complications, and treatment with and without dialysis. Arch. Intern. Med. (Chicago) 104: 180, 1959. CrossrefGoogle Scholar2. MAHERSCHREINER JFGE: Cause of death in acute renal failure. Arch. Intern. Med. (Chicago) 110: 493, 1962. CrossrefMedlineGoogle Scholar3. WEILSPINK MHWW: The shock syndrome associated with bacteremia due to gram-negative bacilli. Arch. Intern. Med. (Chicago) 101: 184, 1958. CrossrefGoogle Scholar4. KLEEMANMAXWELL CRMH: The nephrotoxicity of antibiotics: a review. Biology of Pyelonephritis, Henry Ford Hospital, International symposium, Edited by E. L. and Kass, E. H., p. 631, Little, Brown & Company, Boston, 1960. Google Scholar5. KUNINFINLAND CMM: Restrictions imposed on antibiotic therapy by renal failure. Arch. Intern. Med. (Chicago) 104: 1030, 1959. CrossrefMedlineGoogle Scholar6. KUNINCHALMERLEEVYSEBASTYENLIEBERFINLAND CMTCCMSCCSM: Absorption of orally administered neomycin and kanamycin. New Eng. J. Med. 262: 380, 1960. CrossrefMedlineGoogle Scholar7. JAWETZ E: Polymyxin, colistin and bacitracin. Ped. Clinics No. Amer. 8: 1057, 1961. CrossrefMedlineGoogle Scholar8. KUNINFINLAND CMM: Persistence of antibiotics in blood of patients with acute renal failure. III. Penicillin, streptomycin, erythromycin and kanamycin. J. Clin. Invest. 38: 1509, 1959. CrossrefMedlineGoogle Scholar9. KUNINREESFINLAND CMSBM: Persistence of antibiotics in blood of patients with acute renal failure. I. Tetracycline and chloretetracycline. J. Clin. Invest. 38: 1487, 1959. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Charlottesville, VirginiaThis work was supported in part by the Virginia Heart Association.Requests for reprints should be addressed to Nuzhet O. Atuk, M.D., Department of Medicine, University of Virginia School of Medicine, Charlottesville, Virginia. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByChemotherapy with Antibacterial AgentsChemically Defined Antimicrobial Susceptibility Test Medium for Pseudomonas aeruginosaDrug Selection and Dosage in Renal InsufficiencyPosttraumatic MeningitisAntibiotics and the KidneyAdverse Effects of Sodium Colistimethate Manifestations and Specific Reaction Rates During 317 Courses of TherapyJAN KOCH-WESER, M.D., VICTOR W. SIDEL, M.D., ELIZABETH B. FEDERMAN, R.N., PAULA KANAREK, M.A., DIANA C. FINER, B.A., ANN E. EATON, M.Ed.Host Determinants of Response to Antimicrobial AgentsManagement of postoperative acute renal failurePolymyxins, Colistin, Bacitracin, Ristocetin and VancomycinAkutes NierenversagenDeep Electrical Burn Complicated by Anuria and Pseudomonas SepticaemiaA Guide to Use of Antibiotics in Patients with Renal Disease A Table of Recommended Doses and Factors Governing Serum LevelsCALVIN M. KUNIN, M.D., F.A.C.P.ABSORPTION, DISTRIBUTION, EXCRETION AND FATE OF KANAMYCINSTATUS OF KANAMYCIN IN THE TREATMENT OF SURGICAL INFECTIONSTHE USE OF KANAMYCIN IN SELECTED PATIENTS WITH SERIOUS INFECTIONS CAUSED BY GRAM-NEGATIVE BACILLI: SERUM CONCENTRATION AND INHIBITION STUDIES IN PATIENTS WITH AZOTEMIA GIVEN REDUCED DOSESKANAMYCIN IN THE TREATMENT OF PATIENTS WITH DIMINISHED KIDNEY FUNCTIONDiscussion of the PaperGram-negative rod bacteremiaToxic nephropathyThe Therapeutic Success and Nephrotoxicity of Colistin in Acute and Chronic Nephropathies with Impaired Renal FunctionUse of antibiotics and chemotherapeutics in surgery 1 January 1964Volume 60, Issue 1Page: 28-38KeywordsAntibioticsEndotoxinsEscherichia coli infectionsGram negative bacterial infectionsHeartInfectious diseasesLungsRenal diseasesUrinary tract infections Issue Published: 1 January 1964 PDF DownloadLoading ...