HEMORRHAGIC ENCEPHALOPATHY DUE TO ACETARSONE
Authors: Harry L. Segal
Journal: Annals of Internal Medicine (1940)

Case Reports1 December 1940HEMORRHAGIC ENCEPHALOPATHY DUE TO ACETARSONEHARRY L. SEGAL, M.D.HARRY L. SEGAL, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-14-6-1083 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe properties and uses of acetarsone, more commonly known as stovarsol and introduced mainly for the treatment of congenital syphilis, have recently been thoroughly reviewed by Maxwell and Glaser.1 It is a pentavalent arsenic compound known as Ehrlich's 594, stovarsol in France, spirocid in Germany, and osarol in Russia. Chemically it is the acetyl derivative of 3 amino 4-hydroxy-phenyl-arsonic acid.In addition to its use in syphilis it has been employed in various other conditions, and especially in amebic dysentery,1with apparently good results. Because of its favorable action in amebic dysentery it has been used in other types of...Bibliography1. MAXWELLGLASER CHJ: Treatment of congenital syphilis with acetarsone given by mouth, Am. Jr. Dis. Child., 1932, xliii, 1461. Google Scholar2. REITER G: Über Enzephalitis nach Spirozid, Deutsch. med. Wchnschr., 1932, lviii, 1482. CrossrefGoogle Scholar3. DARGEINDORÉ GG: Un cas de mort par le tréparsol, Bull. et mém. Soc. méd. d. hôp. de Par., 1926, l, 1653-1656. Google Scholar4. MAY #: Death from tréparsol, Bull. et mém. Soc. méd. d. hôp. de Paris, 1926, l, 1176-1178. Google Scholar5. MILIANGARNIER G: Apoplexie sérieuse par le tréparsol, Rev. franç. de dermat. et de vénéréol., 1928, iv, 359-362. Google Scholar6. RAIZIN GW: Personal communication, Dermatological Research Laboratories, Philadelphia, Pa. Google Scholar7. OPITZ H: Zur Anwendung des Spirozids bei Lymphogranulomatose, Deutsch. med. Wchnschr., 1930, lvi, 659. CrossrefGoogle Scholar8. ASCHNER B: Schweres cerebrales Krankheitsbild nach Spirocid, Wien. klin. Wchnschr., 1930, xliii, 581-583. Google Scholar9. GLASER J: Clinical arsenical myelitis and neuritis due to acetarsone, Am. Jr. Dis. Child., 1934, xlviii, 134. CrossrefGoogle Scholar10. GLOBUSGINSBURG JHSW: Pericapillary encephalorrhagia due to arsphenamine (so-called arsphenamine encephalitis), Arch. Neurol. and Psychiat., 1933, xxx, 1226. CrossrefGoogle Scholar11. GLASERIMMERMANIMMERMAN MACPSW: So-called hemorrhagic encephalitis and myelitis secondary to intravenous arsphenamine, Am. Jr. Med. Sci., 1935, clxxxix, 64. CrossrefGoogle Scholar12. RUSSELL DS: Changes in central nervous system following arsphenamine medication, Jr. Path. and Bact., Edinburgh, 1937, xlv, 357. CrossrefGoogle Scholar13. OSTERBERGKERNHAN AEJW: The presence of arsenic in the brain and its relation to pericapillary hemorrhages or so-called acute hemorrhagic encephalitis, Am. Jr. Clin. Path., 1934, iv, 362. CrossrefGoogle Scholar14. BAKER AB: Hemorrhagic encephalitis, Am. Jr. Path., 1935, xi, 185. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Rochester, New York*Received for publication June 21, 1939.From the Department of Medicine, the University of Rochester School of Medicine and Dentistry, and the Medical Clinic of the Strong Memorial and Rochester Municipal Hospitals. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 December 1940Volume 14, Issue 6Page: 1083-1088KeywordsAmino acidsArsenicBrain diseasesCongenital syphilisDentistryDysenteryHospital medicineSyphilis ePublished: 1 December 2008 Issue Published: 1 December 1940 PDF downloadLoading ...