tbuckley/cabot-search huggingface dataset:
Successful outcome of cryosurgery in patients with granuloma annulare
Authors: U. BLUME-PEYTAVI, CH. C. ZOUBOULIS, H. JACOBI, A. SCHOLZ, S. BISSON, C.E. ORFANOS
Journal: British Journal of Dermatology (1994)

Several therapeutic methods have been employed in the management of localized granuloma annulare (GA), with varying degrees of success. We performed a prospective trial to evaluate the efficacy, cosmetic results, and safety of cryosurgical treatment in GA. Thirty-one patients with localized GA were treated by cryosurgery, using the contact method. Nitrous oxide (-86 degrees C) or liquid nitrogen (-196 degrees C) were used as refrigerants, and were applied with closed probes; each lesion was treated with one freeze-thaw cycle of 10-60 s per session. If necessary, treatment was repeated after 20-30 days. Resolution of the lesions was obtained in all patients, and in 25 of 31 patients (80.6%) they resolved after a single freeze-thaw cycle. Relapse occurred in only one of 11 patients who were followed for more than 2 years, and this occurred 16 months after treatment. Excellent cosmetic results were obtained in 14 of 28 patients who were eligible for evaluation (50%), and good results in 11 (39.3%). The cosmetic result obtained by cryosurgery with nitrous oxide was independent of the size of the lesion, whereas in the group of patients treated with liquid nitrogen a better cosmetic result was obtained with smaller lesions (comparison of lesions < or = 2.40 cm2 with those > 2.40 cm2; P = 0.04). The duration of the lesion, its location, previous treatment with another method, and the number of treatment sessions, did not have any influence on the cosmetic result. The treatment was generally well tolerated. Blister formation occurred in all patients.(ABSTRACT TRUNCATED AT 250 WORDS)
Thrombokinetics in giant cell arteritis, with special reference to corticosteroid therapy.
Authors: A L Bergstrom, B A Bengtsson, L B Olsson, B E Malmvall, J Kutti
Journal: Annals of the Rheumatic Diseases (1979)

Duplicate platelet survival studies were carried out on 8 patients with giant cell arteritis (GCA), once before the institution of any therapy, and the second time when they were in a completely asymptomatic phase after having received corticosteroid treatment. The time interval between the studies ranged between 5 and 14 months. In the first study the mean peripheral platelet count was 486 +/- 25 X 10(9)/l and in the second 326 +/- 25 X 10(9)/l. The difference between the means was highly significant (P less than 0.001). The mean life-span of the platelets was normal in the duplicate experiments (6.7 +/- 0.3 and 7.3 +/- 0.4 days, respectively). Platelet production rate was significantly (P less than 0.001) raised in the first experiment but became normal in response to corticosteroid therapy. It is concluded that the thrombocytosis seen in GCA is reactive to the inflammation present in this disease, and it seems reasonable to assume that the reduction in the peripheral platelet count which occurs in response to corticosteroid therapy accurately reflects the clinical improvement of the patient.
Cancer incidence in England's deprived areas is 16% higher than in rich areas
Authors: R. Ushiro-Lumb
Journal: BMJ (2010)

As many as 14 000 cases of cancer could be prevented each year in England if everyone was as healthy as the richest 20% in the country, a study has found.

Between 2000 and 2004 there were 21% more diagnoses of cancer in men who live in the most deprived areas of England than in the least deprived. The gap for women was marginally lower at 11%, found the study by the National Cancer Intelligence Network.

Experts believe that the gap in cancer …
THE GALVANO-CAUTERY IN LARYNGOLOGY, WITH CASES.
Authors: GEO. W. WEBSTER
Journal: JAMA (1891)

the laryngeal mirror.If the etiology points to portal congestion, chloral hydrate would be indi¬ cated ; if a syphilitic taint, mercury ; if tubercu¬ losis, iron and cod-liver oil; if glandular enlarge¬ ment, one of the iodides.The necessity of constantly breathing pure air cannot be too strongly dwelt upon.Let the diet be light, di¬ gestible and nutritious.The plethora of glut¬ tony should be guarded against.For the treat¬ ment of chronic laryngitis, I know of no one remedy so efficient as alcohol.Unlike many others, it is applicable in all cases, irrespective of cause.It is a local and constitutional tonic, acting not only beneficially on the lining mem¬ brane of the air passages, but also as a systemic stimulant.Nasal stenosis is reduced, and as a rule per¬ manently cured, by alcoholic inhalation.Phar¬ yngitis is relieved, and the uvula-usually elon¬ gated in laryngitis-is rendered normal.Several cases of tuberculosis, well advanced, have been checked, in my practice, by alcoholic inspiration.Wearing a full beard among men, has been strong¬ ly recommended by some medical writers as a remedy, both curative and preventive, for chronic laryngitis.A thermometrical sameness, secured either by latitude, altitude or artificial methods, must not be overlooked, as one of the most potential of the remedial agents-but by all means, let your treatment be measured by months rather than days.
Acute tolerance to effects of topical glucocorticosteroids
Authors: ANTHONY VIVIER, RICHARD B. STOUGHTON
Journal: British Journal of Dermatology (1976)

Tachyphylaxis (acute tolerance) to two important actions of topical glucocorticosteroids is demonstrated. In humans, topically active glucocorticoids applied to the skin cause vasoconstriction initially but this response fades with successive applications. In hairless mouse epidermis, inhibition of DNA synthesis and mitosis is caused by one application of a glucocorticoid but with repeated administration of the drug this effect is lost. The degree of inhibition of cell division appears to be similar 30 and 54 h after one application of steroid to that following three or five applications during such a time period. These findings suggest that an optimum therapeutic approach to the use of these agents exists.
National Amyotrophic Lateral Sclerosis Case Registry
Authors: Myron I. Varon
Journal: JAMA (1979)

<h3>To the Editor.—</h3> The Amyotrophic Lateral Sclerosis Society of America and the Department of Neurology of the University of Southern California maintain a national amyotrophic lateral sclerosis (ALS) case registry. This is the first truly national ALS case registry effort ever conducted. We are attempting to collect information on all available ALS patients, which will enable future meaningful research into the cause, cure, and prevention of ALS. In addition, the ALS Society maintains an information fact sheet program to provide practical, readily available, and medically correct information to ALS patients and their families on many of the aspects of the management of ALS disease. In addition to funding ALS research, the ALS Society wants to help ALS patients and their families to cope more adequately with their disease. Information will be provided on request to any medical practitioner who would forward it to his patients or to the patients or
Study had insufficient power to investigate safety
Authors: J. E. Rossouw, J. E. Manson, A. M. Kaunitz, M. L. Stefanick
Journal: BMJ (2012)

There are several concerns about the robustness of Schierbeck and colleagues’ findings.1 The open label design means that the trial could not control for placebo effect, and knowledge of active treatment could have led to differential ascertainment of outcomes.

The composite outcome of mortality, myocardial infarction, and heart failure was not prespecified in the design paper, …
Increased metal allergy in patients with failed metal‐on‐metal hip arthroplasty and peri‐implant T‐lymphocytic inflammation
Authors: P. Thomas, L. R. Braathen, M. Dörig, J. Auböck, F. Nestle, T. Werfel, H. G. Willert
Journal: Allergy (2009)

In 16 patients with revised metal-on-metal arthroplasty and peri-implant lymphocytic inflammation, we verified the role of metal hypersensitivity by patch testing (PT) and lymphocyte transformation test (LTT).In the 16 patients with lymphocyte dominated periprosthetic inflammation, allergy history was obtained by a questionnaire, specific serum IgE to aeroallergens was measured to assess atopy, PT to standard and metal series was performed and metal sensitivity was further assessed by LTT using blood mononuclear cells.Revision surgery was performed because of pain (8/16), osteolysis (4/16), dislocation (3/16) and loosening of the stem (1/16). Histological examination showed perivascular infiltrates of T lymphocytes, high endothelial venules, fibrin exudation and accumulation of macrophages with drop-like inclusions. Five patients had a history of cutaneous metal allergy and atopy was found in 25% of the patients. In 13/16 patients (81%), systemic metal sensitivity was found based on PT and/or LTT. Patch test reactions were seen in 11/16 patients (69%; partly multiple reactions/patient): 7/16 to Cobalt (Co), 7/16 to Chromium (Cr), 4/16 to Nickel (Ni), and one each to Molybdenum (Mo) and Manganese (Mn). Ten of 16 patients (62%) showed enhanced LTT reactivity to metals: 7/16 to Ni, 7/16 to Co, 5/16 to Cr, 5/16 to Mo and 4/16 to Mn.The lymphocyte dominated peri-implant inflammation may well reflect an allergic hyper-reactivity in these patients, given the high rate of concomitantly found metal allergy. Despite the overall incidence of metal implant allergy being low, allergic reactions should be included as differential diagnosis in failed metal-on-metal arthroplasty.
'Storage Pool Disease' of Platelets
Authors: Mohan Singh Khurana
Journal: JAMA (1980)

A woman with congenital cavernous hemangiomas and a bleeding diathesis since childhood was found to have a qualitative platelet defect characterized by the absence of a second-phase aggregation induced by epinephrine, adenosine diphosphate (ADP), and collagen, accompanied by decreased levels of adenosine triphosphate (ATP) and ADP, with a high ATP-ADP ratio consistent with the diagnosis of "storage pool disease" of the platelets. There was no evidence of disseminated intravascular coagulation or circulating antiplatelet antibodies. The bleeding tendency responded to platelet transfusion. (<i>JAMA</i>244:169-171, 1980)
988 PROSPECTIVE MULTISITE RANDOMIZED TRIAL OF INTEGRATED CARE (IC) VS. USUAL CARE (UC) FOR IMPROVING ACCESS TO ANTIVIRAL THERAPY FOR HIGH RISK PATIENTS WITH CHRONIC HCV
Authors: S.B. Ho, E.J. Groessl, N. Brau, R.C. Cheung, K.R. Weingart, M.A. Ward, M. Sklar, T.E. Phelps, S.G. Marcus, M.M. Wasil, A.S. Tisi, L.K. Huynh, S.K. Robinson
Journal: Journal of Hepatology (2012)
Fenfluramine and Phentermine
Authors: Diane Howlin
Journal: Annals of Internal Medicine (2001)

Letters6 November 2001Fenfluramine and PhentermineDiane Howlin, MDDiane Howlin, MDChelsea Village Internal Medicine; Chelsea, MI 48118 (Howlin)Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-135-9-200111060-00018 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:The editorial by St. John Sutton on the diet medications fenfluramine and phentermine (1) contains two important factual errors. The author states that fenfluramine was introduced in 1959, when in fact phentermine was introduced in 1959. This is important because of the long safety record established for phentermine. Fenfluramine was introduced in 1973.In the third paragraph, the author states, “Treatment of obesity with fenfluramine–phentermine was abruptly halted in 1997, when both agents were voluntarily withdrawn from the market by the manufacturer.” Phentermine is still readily available on the market under several trade names, including Adipex-P (GATE ...Reference1. St. John Sutton M. Silver lining to the cloud over anorexogen-related cardiac valvulopathy? [Editorial]. Ann Intern Med. 2001;134:335-7. LinkGoogle Scholar Author, Article, and Disclosure InformationAffiliations: Chelsea Village Internal Medicine; Chelsea, MI 48118 (Howlin) PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoSilver Lining to the Cloud over Anorexogen-Related Cardiac Valvulopathy? Martin St John Sutton Anorexogen-Related Cardiac Valvulopathy Richard B. Rothman Metrics Cited byAnorexogen-Related Cardiac ValvulopathyRichard B. Rothman, MD, PhD 6 November 2001Volume 135, Issue 9Page: 840-841KeywordsDietObesitySafety ePublished: 6 November 2001 Issue Published: 6 November 2001 Copyright & PermissionsCopyright © 2001 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Comparison of Lifestyle-Based and Traditional Cardiovascular Disease Prediction in a Multiethnic Cohort of Nonsmoking Women
Authors: Nina P. Paynter, Michael J. LaMonte, JoAnn E. Manson, Lisa W. Martin, Lawrence S. Phillips, Paul M Ridker, Jennifer G. Robinson, Nancy R. Cook
Journal: Circulation (2014)

Healthy levels of lifestyle factors can reduce the risk of cardiovascular disease. However, except for smoking status, often considered a traditional risk factor, their effect on cardiovascular risk prediction is unclear.
Recovery of contractility of viable myocardium during inotropic stimulation is not dependent on an increase of myocardial blood flow in the absence of collateral filling
Authors: Francesco Barillà, Giuseppe De Vincentis, Enrico Mangieri, Massimo Ciavolella, Gaetano Pannitteri, Francesco Scopinaro, Giuseppe Critelli, Pietro Paolo Campa
Journal: Journal of the American College of Cardiology (1999)
Pharmacokinetics and Pharmacodynamics of the Long-Acting Insulin Analog Glargine After 1 Week of Use Compared With Its First Administration in Subjects With Type 1 Diabetes
Authors: Francesca Porcellati, Paolo Rossetti, Natalia Busciantella Ricci, Simone Pampanelli, Elisabetta Torlone, Susana Hernandez Campos, Anna Marinelli Andreoli, Geremia B. Bolli, Carmine G. Fanelli
Journal: Diabetes Care (2007)

Pharmacokinetics and pharmacodynamics of the long-acting insulin analog glargine (1) are superior to those of insulin NPH (2–9). In the clinical setting, this translates into lower risk of nocturnal hypoglycemia (10–13), lower A1C (provided that appropriate requirements of mealtime rapid-acting insulin are met) (11–13), and the convenience of once (12), compared with multiple, administration of NPH (14). However, no study has examined subjects after several days of its use versus the “first” subcutaneous injection.

The present studies were undertaken to establish the pharmacokinetics and pharmacodynamics of insulin glargine in type 1 diabetes after 1 week of its once-daily use and to compare it with those observed after the first injection.

After institutional review board approval, 20 type 1 diabetic subjects (12 male subjects, age 31 ± 2 years, type 1 diabetes duration 11 ± 1 years, BMI 23.3 ± 0.4 kg/m2, fasting plasma C-peptide <0.02 nmol/l, and A1C 7.1 ± 0.2%) using NPH as basal insulin and human regular insulin ( n = 7) or lispro insulin ( n = 13), in combination with NPH at each meal as previously described (14), were studied.

During a 2-week run-in period, subjects continued their previous model of insulin therapy, i.e., human regular insulin or the rapid-acting insulin analog lispro at breakfast, lunch, and dinner and NPH insulin at bedtime, or even at each meal in those patients ( n = 13) who used lispro (14). Thereafter, subjects were studied with the glucose clamp technique after subcutaneous injection of 0.3 units/kg insulin glargine as previously described (6). Subjects …
Dissecting Aneurysm of the Posterior Cerebral Artery
Authors: Dimitri Renard, Didier Milhaud
Journal: New England Journal of Medicine (2007)

This 43-year-old man presented with hemianesthesia involving the right arm, the right leg, and the right side of the face. MRI scans revealed a dilatation of the left posterior cerebral artery, with a double lumen.
A digital computer model of the vectorcardiogram: A design permitting the simulating of abnormal conduction in the ventricles
Authors: J. R. PALMER, K. H. MCLEAN, T. S. DILLON
Journal: Cardiovascular Research (1973)

Journal Article A digital computer model of the vectorcardiogram: A design permitting the simulating of abnormal conduction in the ventricles Get access J. R. PALMER, J. R. PALMER From the Department of Medicine, Monash University, Melbourne, Australia Search for other works by this author on: Oxford Academic PubMed Google Scholar K. H. MCLEAN, K. H. MCLEAN 1 From the Department of Medicine, Monash University, Melbourne, Australia 1Address for reprints: Associate Professor K. H. McLean, Monash University Department of Medicine, Prince Henry's Hospital, St. Kilda .Road, Melbourne, 3004, Australia. Search for other works by this author on: Oxford Academic PubMed Google Scholar T. S. DILLON T. S. DILLON From the Department of Medicine, Monash University, Melbourne, Australia Search for other works by this author on: Oxford Academic PubMed Google Scholar Cardiovascular Research, Volume 7, Issue 6, November 1973, Pages 849–858, https://doi.org/10.1093/cvr/7.6.849 Published: 01 November 1973
Alterations in bile ducts and peribiliary microcirculation in rats after common bile duct ligation
Authors: Shu Nakano, Joji Haratake, Hiroshi Hashimoto
Journal: Hepatology (1995)

The chronological changes in ductular epithelium and peribiliary capillary plexuses (PBPs) after bile duct ligation are not well understood. Therefore, we examined alterations in both intrahepatic bile ductules and peribiliary microcirculation in rats after ligation of the common bile duct using immunohistochemistry, transmission electron microscopes (TEM), and scanning electron microscopes (SEM). Ductular proliferations appeared first in the peripheral areas of the portal spaces and then gradually advanced along with increasing jaundice. Distorted configuration of the hepatic parenchyma with interconnecting stroma rich in irregular ductules developed 4 weeks after the ligation. Numerous biliary cell types and cells of types intermediate between hepatocytes and biliary cells together with poorly fenestrated capillary-type vessels appeared in the periportal parenchyma, in association with an increased number of canalicular-ductular junctions on TEM. These biliary cells were often found within the lobules and apart from the stroma. SEM examination of hepatic microvascular casts using methacrylated resin showed formation of irregular portal and periportal capillary networks, partly derived from coarsened sinusoids. Direct connections between the newly formed capillary networks and the pre-existing PBPs or sinusoids were numerous, although there were few direct connections between the capillary networks and the hepatic arterial branches. Thus, these proliferated ductules and newly formed complicated capillary networks might play an important role in the effective transport of biliary materials between hepatocytes and native bile ducts or proliferated ductules through the altered microcirculation after bile duct ligation.
Confidence Intervals for Reporting Results of Clinical Trials
Authors: RICHARD SIMON
Journal: Annals of Internal Medicine (1986)

Tests of statistical significance are often used by investigators in reporting the results of clinical research. Although such tests are useful tools, the significance levels are not appropriate indices of the size or importance of differences in outcome between treatments. Lack of "statistical significance" can be misinterpreted in small studies as evidence that no important difference exists. Confidence intervals are important but underused supplements to tests of significance for reporting the results of clinical investigations. Their usefulness is discussed here, and formulas are presented for calculating confidence intervals with types of data commonly found in clinical trials.
Positron Emission Tomography in Dyke-Davidoff-Masson Syndrome
Authors: K Kulkarni, M R. Sperling, C Intenzo
Journal: Clinical Nuclear Medicine (2005)

Dyke-Davidoff-Masson syndrome is clinically characterized by hemiparesis, hemiplegia, seizures, mental retardation, and facial asymmetry secondary to congenital or early childhood vascular insult. A 21-year-old man with Dyke-Davidoff-Masson syndrome presented with uncontrolled seizures. The authors present the magnetic resonance (MR) and positron emission tomography (PET) findings of this syndrome.
Medicinal Uses of Marijuana
Authors: Richard Bayer
Journal: Annals of Internal Medicine (1997)

Letters15 December 1997Medicinal Uses of MarijuanaRichard Bayer, MDRichard Bayer, MDPortland, OR 97225Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-127-12-199712150-00032 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:Voth and Schwartz [1] sound like patriarchal moralists, not scientists. They conveniently ignore scientific studies, patient anecdotes, court decisions, and voters who disagree with them when discussing a 5000-year-old herbal medicine. Many physicians and organizations-including Dr. Kassirer, Editor of The New England Journal of Medicine[2]; the National Institutes of Health [3]; the American Public Health Association; the San Francisco Medical Society; the California Academy of Family Physicians; Harvard professor Dr. Grinspoon; the Federation of American Scientists; and the National Academy of Sciences [4] -believe that cannabis may be beneficial and that further research should be done. Users ...References1. Voth EA, Schwartz RH. Medicinal applications of delta-9-tetrahydrocannabinol and marijuana. Ann Intern Med. 1997; 126:791-8. Google Scholar2. Kassirer JP. Federal foolishness and marijuana [Editorial]. N Engl J Med. 1997; 336:366-7. Google Scholar3. Voelker R. NIH panel says more study is needed to assess marijuana's medicinal use. JAMA. 1997; 277:867-8. Google Scholar4. NORML Medical Marijuana Documents ONLINE, http://www.natlnorml.org/medical/medmj.shtml. Google Scholar5. MAPS Newsletter on Marijuana and AIDS Wasting Syndrome Study. http://www.maps.org./news-letters/v06n2/06207mmj.html. Google Scholar Author, Article, and Disclosure InformationAuthors: Richard Bayer, MDAffiliations: Portland, OR 97225 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 15 December 1997Volume 127, Issue 12Page: 1134KeywordsCannabisDrug abuseDrugsHerbal medicineMarijuanaMotivationPain managementPrevention, policy, and public healthScientistsTreatment guidelines ePublished: 15 August 2000 Issue Published: 15 December 1997 Copyright & PermissionsCopyright © 1997 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...