THE CURRENT STATUS OF CHEMOTHERAPY OF SYSTEMIC FUNGAL DISEASE
Authors: J P UTZ, A TREGER
Journal: Annals of Internal Medicine (1959)

Article1 December 1959THE CURRENT STATUS OF CHEMOTHERAPY OF SYSTEMIC FUNGAL DISEASEJOHN P. UTZ, M.D., ALBERT TREGER, M.D.JOHN P. UTZ, M.D.Search for more papers by this author, ALBERT TREGER, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-51-6-1220 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThirty years ago this June, Fleming1first reported the antibacterial action of cultures of Penicillium, thus in one sense inaugurating the Antibiotic Era. During this period many antibiotics have been developed and used successfully in treating bacterial diseases. However, only two mycoses, actinomycosis and nocardiosis, have responded to any of these antibacterial drugs. In the four years since a symposium on the therapy of systemic fungal infections,2a number of new and promising antifungal drugs have been developed, and one of these, amphotericin, has been given clinical trials in a large number of patients. These considerations have prompted this present...Bibliography1. Fleming A: On the antibacterial action of cultures of a penicillium with special reference to their use in isolation of B. influenzae , Brit. J. Exper. Path. 10: 226, 1929. Google Scholar2. California University, University of Los Angeles, School of Medicine and Medical Extension: Therapy of fungus diseases, an international symposium, 1955, Little, Brown and Company, Boston. Google Scholar3. BatesCruickshank MG: Thoracic actinomycosis, Thorax 12: 99, 1957. CrossrefMedlineGoogle Scholar4. UtzGermanLouriaEmmonsBartter JPJLDBCWFC: Pulmonary aspergillosis with cavitation, New England J. Med. 260: 264, 1959. CrossrefMedlineGoogle Scholar5. Staib F: Aspergillus bei Appendizitis und Zokumphlegmone, Deutsche med. Wchnschr. 84: 220, 1959. CrossrefMedlineGoogle Scholar6. Smith DT: Miscellaneous fungus diseases, J. Chron. Dis. 5: 528, 1957. CrossrefMedlineGoogle Scholar7. BauerFlanaganSheldon HJFWH: Experimental cerebral mucormycosis in rabbits with alloxan diabetes, Yale J. Biol. and Med. 28: 29, 1955. MedlineGoogle Scholar8. BlankenbergVerhoeff HWD: Mucormycosis of the lung: a case without significant predisposing factor, Am. Rev. Tuberc. 79: 357, 1959. MedlineGoogle Scholar9. Christie A: The disease spectrum of human histoplasmosis, Ann. Int. Med. 49: 544, 1958. LinkGoogle Scholar10. LouriaFeder DBN: Sulfonamides in experimental histoplasmosis, Antibiotics and Chemotherapy 7: 471, 1957. Google Scholar11. MichaelVogel MRA: Histoplasmosis: report of a case with observations on management, New England J. Med. 251: 884, 1954. CrossrefMedlineGoogle Scholar12. EllisCallander MRJ: Treatment of histoplasmosis with MRD-112, J. Tennessee M. A. 48: 411, 1955. Google Scholar13. EmmonsHaberman CWRT: Ascosin in the treatment of experimental histoplasmosis in mice, Antibiotics and Chemotherapy 3: 1204, 1953. Google Scholar14. UtzLouriaFederEmmonsMcCullough JPDBNCWNB: A report of clinical studies on the use of amphotericin B in patients with systemic fungal diseases, in Antibiotics Annual, 1957-1958, Medical Encyclopedia, Inc., New York. Google Scholar15. UtzTregerMcCulloughEmmons JPANBCW: Amphotericin B: intravenous use in 21 patients with systemic fungal diseases, in Antibiotics Annual, 1958-1959, Medical Encyclopedia, Inc., New York. Google Scholar16. SeaburyDascomb JHHE: Experience with amphotericin B for the treatment of systemic mycosis, Arch. Int. Med. 102: 960, 1958. CrossrefGoogle Scholar17. LittmanZimmerman MLLE: Cryptococcosis, 1956, Grune and Stratton, New York. Google Scholar18. Emmons CW: Silver in the treatment of experimental cryptococcosis, Antibiotics and Chemotherapy 6: 598, 1956. Google Scholar19. ShapiroNeal LLJB: Torula meningitis, Arch. Neurol. and Psychiat. 13: 174, 1925. CrossrefGoogle Scholar20. RubinFurcolow HML: Promising results in cryptococcal meningitis, Neurology 8: 590, 1958. CrossrefMedlineGoogle Scholar21. NewcomerSternbergWrightReisner VDTHETRM: Current status of amphotericin B in the treatment of systemic fungus infections, J. Chron. Dis. 9: 353, 1959. CrossrefMedlineGoogle Scholar22. HarrellBocoboCurtis ERFCAC: A study of North American blastomycosis and its treatment with stilbamidine and 2 hydroxystilbamidine, Ann. Int. Med. 43: 1076, 1955. LinkGoogle Scholar23. ChernissWaisbren EIBA: North American blastomycosis: a clinical study of 40 cases, Ann. Int. Med. 44: 105, 1956. LinkGoogle Scholar24. BaumSchwartz GLJ: Coccidioidomycosis: a review, Am. J. M. Sc. 230: 82, 1955. CrossrefMedlineGoogle Scholar25. LittmanHorowitzSwadey MLPLJG: Coccidioidomycosis and its treatment with amphotericin B, Am. J. Med. 24: 568, 1958. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Bethesda, Maryland*Received for publication August 3, 1959.Presented at the Fortieth Annual Session of The American College of Physicians. Chicago, Illinois, April 21, 1959.From the U. S. Department of Health, Education, and Welfare, Public Health Service, National Institutes of Health, National Institute of Allergy and Infectious Diseases, Bethesda, Maryland.†Present address: Cleveland Metropolitan General Hospital, Cleveland, Ohio.Requests for reprints should be addressed to John P. Utz, M.D., Chief, Infectious Disease Service, Laboratory of Clinical Investigation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda 14, Maryland. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byAn evolution of therapy for mucocutaneous candidiasis3 Biological Activity of Polyene AntibioticsAmphotericin B Methyl Ester Hydrochloride and Amphotericin B: Comparative Acute ToxicityDrug—induced alterations in the ultrastructural organization of Histoplasma capsulatum and Blastomyces dermatitidisSurvival of candida septicaemia treated with amphotericin BProgressive Disseminated Histoplasmosis A Prospective Study of 26 PatientsJAMES W. SMITH, M.D., JOHN P. UTZ, M.D., F.A.C.P.North American BlastomycosisNorth American BlastomycosisNocardiosis: A reviewDiagnostik und Therapie der Mykosen innerer Organe6 The Literature of Medicinal ChemistryAspergillus fumigatus Endocarditis Report of a Case Diagnosed During LifeHUBERT I. CAPLAN, M.D., EMANUEL FRISCH, M.D., JOHN D. HOUGHTON, M.D., MERRILL S. CLIMO, M.D., GEORGE A. NATSIOS, B.SC.Pneumonic aspergillosis complicating healed tuberculosis.Fungal infections complicating acute leukemiaDiagnostic and Prognostic Value of Clinical and Laboratory Findings in Cryptococcal MeningitisAmphotericin B Nephrotoxicity with Irreversible Renal FailureFRANK J. TAKACS, M.D., ZYGMUNT M. TOMKIEWICZ, M.D., JOHN P. MERRILL, M.D., F.A.C.P.The use of Trichomycin in the treatment of vulvovaginal mycosis in pregnant womenThe Use of Amphotericin B in Blastomycosis, Cryptococcosis and HistoplasmosisThe Renal Lesion Related to Amphotericin B Treatment for CoccidioidomycosisThe Diagnosis and Treatment of Bacterial EndocarditisSYSTEMIC CANDIDIASISABDOMINAL AORTIC ANEURYSMSEndokarditis durch Candida parapsilosisSynergism between specific immune globulin and antibiotics in therapy of experimental blastomycosisInvasive Pulmonary AspergillosisOn the nephrotoxicity of amphotericin B in manCandida albicans Endocarditis Successfully Treated with Amphotericin BCandida endocarditisEarly recognition and therapy of disseminated coccidioidomycosisAmphotericin BSurgical Cure of Candida albicans Endocarditis with Open-Heart SurgeryTHERAPY WITH AMPHOTERICIN B IN NORTH AMERICAN BLASTOMYCOSIS*ROBERT S. ABERNATHY, M.D., G. THOMAS JANSEN, M.D.FATAL TOXIC REACTION TO AMPHOTERICIN B IN CRYPTOCOCCAL MENINGO-ENCEPHALITIS*BALDO M. CARNECCHIA, M.D., JOHN F. KURTZKE, M.D.ANALYSIS OF AMPHOTERICIN TREATMENT FAILURES IN SYSTEMIC FUNGAL DISEASE 1 December 1959Volume 51, Issue 6Page: 1220-1229KeywordsAntibioticsAntifungalsDrug therapyDrugsFungal diseasesHistoplasmosisInfectious diseasesMedical servicesMycosesNocardiosis Issue Published: 1 December 1959 PDF downloadLoading ...