Elevated Serum Creatine Kinase Level in Diabetic Patients with Nephrotic Syndrome: A Role of Fluid Retention
Authors: MATSUO TANIYAMA
Journal: Annals of Internal Medicine (1987)

Brief Reports1 May 1987Elevated Serum Creatine Kinase Level in Diabetic Patients with Nephrotic Syndrome: A Role of Fluid RetentionMATSUO TANIYAMA, M.D., SHISEI YOH, M.D., YOSHIAKI ASABA, M.D., TARO MARUYAMA, M.D., IZUMI TAKEI, M.D., KUNIZO KATAOKA, M.D.MATSUO TANIYAMA, M.D.Search for more papers by this author, SHISEI YOH, M.D.Search for more papers by this author, YOSHIAKI ASABA, M.D.Search for more papers by this author, TARO MARUYAMA, M.D.Search for more papers by this author, IZUMI TAKEI, M.D.Search for more papers by this author, KUNIZO KATAOKA, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-106-5-711 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptElevation of serum levels of the MM isoenzyme of creatine kinase usually reflects the destruction of skeletal muscles. However, creatine kinase levels can increase without muscle destruction, and in diabetes mellitus, the elevation of this enzyme level has been noted in patients with ketoacidosis (1, 2). We treated a patient with diabetes and the nephrotic syndrome in whom the serum level of the MM isoenzyme of creatine kinase was extremely high despite no evidence of coexisting muscle disease. In this patient, the creatine kinase level decreased to normal after hemodialysis therapy was begun, and we suspected that fluid retention had...References1. VELEZ-GARCIAHARDYDIOSOPERKOFF EPMG. Cysteine-stimulated serum creatine Phosphokinase: unexpected results. J Lab Clin Med. 1966;68:636-45. MedlineGoogle Scholar2. KNIGHTWILLIAMSSPOONERGOLDBERG ADRD. Serum enzyme changes in diabetic ketoacidosis. Diabetes. 1974;23:126-31. CrossrefMedlineGoogle Scholar3. COHENGRIFFITHSSTONELEECH IJRT. The creatine kinase profile of a maintenance hemodialysis population: a possible marker of uremic myopathy. Clin Nephrol. 1980;13:235-8. MedlineGoogle Scholar4. KITOTOKINOBUITOGAKOSAKA SHEK. A clinical study of skeletal muscle disorders in diabetes. In: GOTO Y, HORIUCHI A, KOGURE K, eds. Diabetic Neuropathy: Proceedings of the International Symposium on Diabetic Neuropathy and its Treatment. Princeton, New Jersey: Excerpta Medica; 1982:179-84. Google Scholar5. ACHARIANDERSON AM. Serum creatine Phosphokinase in amyotrophic lateral sclerosis: correlation with sex, duration, and skeletal muscle biopsy. Neurology. 1974;24:834-7. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Keio University School of Medicine Tokyo, Japan. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByEvaluation of the mechanism of Danggui-Shaoyao-San in regulating the metabolome of nephrotic syndrome based on urinary metabonomics and bioinformatics approachesAdenomatous ductal proliferation/hyperplasia in the parotid gland associated without any other pathological lesions; a report and survey of the literaturesLaboratory testing in the diagnosis and management of idiopathic inflammatory myopathiesIdiopathic Inflammatory MyopathiesElevated Serum Creatine Kinase Levels in Diabetic Patients with the Nephrotic SyndromePIERRE F. FAUBERT, M.D., JEROME G. PORUSH, M.D. 1 May 1987Volume 106, Issue 5Page: 711-712KeywordsCreatine kinaseDiabetes mellitusEnzymesMusclesSkeletal muscles Issue Published: 1 May 1987 PDF DownloadLoading ...