tbuckley/cabot-search huggingface dataset:
395. Beta-Blockers Restrict Maximum Levels of Transgene Expression Elicited by CMV Promoters in Vascular Smooth Muscle Cells
Authors: Husein K. Salem, Paul A. Kingston, Anthony M. Heagerty
Journal: Molecular Therapy (2004)

Cardiovascular disease provides several putative targets for vascular gene therapy. The cytomegalovirus major immediate-early enhancer/promoter is the most potent and widely used promoter in vascular gene transfer studies. Transgene expression mediated by the major immediate-early enhancer/promoter is sensitive to cyclic adenosine monophosphate (cAMP) through a 19bp response element. β-adrenoceptors modulate production of intracellular cAMP and may thereby affect transgene expression mediated by MIECMV in vascular cells. β-adrenoceptor antagonists (β-blockers) are likely to antagonise any such effect.
745. Innate Immune Responses to Adeno-Associated Virus Vectors
Authors: Anne K. Zaiss, Lindsay R. White, Norman C. W. Wong, Jeffrey S. Bartlett, Daniel A. Muruve
Journal: Molecular Therapy (2004)

Top of pageAbstract
The innate immune response against invading pathogens is an acute inflammatory response that limits the initial infection and initiates host adaptive immunity. Adenovirus vectors (Ad-vectors) cause acute inflammation in vivo, whereas adeno-associated virus (AAV) vectors are not associated with significant inflammation. We previously found that in contrast to Ad-vectors, AAV vectors do not induce the expression of chemokines/cytokines in epithelium-derived cells in vitro. However, in vivo studies showed that AAV vectors induce transient expression of chemokines/cytokines and leukocyte recruitment to mouse liver. This transient activation of innate immune responses by AAV vectors in vivo might contribute to the generation of an adaptive response; the formation of neutralizing antibodies to AAV capsid proteins. Innate immune responses to AAV vectors in the liver were completely abolished in the absence of Kupffer cells (liver macrophages) suggesting that AAV vectors may interact significantly with macrophages. To test whether AAV can directly infect and activate macrophages, THP-1 cells (human monocytes) were transduced with AAV vectors and chemokine expression was analyzed 6 hours post transduction. In contrast to the response in epithelium-derived cells, AAV vectors carrying different transgenes were able to induce various chemokine and pro-inflammatory cytokine mRNAs, including RANTES, IP-10, MIP-1β, MIP-1α, MCP-1 and IL-8 in THP-1 cells in a dose dependent manner. Transductions in the presence of polymyxin B and the use of appropriate vehicles confirmed that the responses were not induced through endotoxin (LPS) or transgene protein contamination. Southern blots indicated internalized vector genomes, suggesting a direct infection and activation of these cells. Furthermore, AAV induced the expression of chemokines in THP-1 cells in the presence or absence of serum suggesting the activation occurs independent of opsonizing proteins or co-factors. Understanding the mechanism of innate immune activation by AAV vectors may allow strategies to minimize humoral adaptive responses permitting the re-administration of these vectors in vivo.
Conversion Efficacy and Safety of Intravenous Ibutilide Compared With Intravenous Procainamide in Patients With Atrial Flutter or Fibrillation 11This study was sponsored by Pharmacia &amp; Upjohn, Kalamazoo, Michigan.22See Appendix Afor a complete list of investigators and study sites.
Authors: Annabelle S Volgman, Peter A Carberry, Bruce Stambler, William R Lewis, George H Dunn, Kimberly T Perry, James T VanderLugt, Peter R Kowey
Journal: Journal of the American College of Cardiology (1998)
Abstract 281: Work history and cancer mortality risks in 90,268 United States radiologic technologists
Authors: Jason J. Liu, Michele M. Doody, Mark P. Little, D Michal Freedman, Bruce H. Alexander, Cari M. Kitahara, Alice J. Sigurdson, Terrence Lee, Preetha Rajaraman, Jeremy S. Miller, Diane M. Kampa, Steven L. Simon, Dale L. Preston, Martha S. Linet
Journal: Cancer Research (2014)

Abstract Objectives: There have been few studies on medical radiation work history factors and cancer mortality. In this nationwide prospective cohort study of United States radiologic technologists, we expanded our previous evaluation of work history and cancer mortality risks, by extending follow-up by 11 years and examining a broader range of cancers. Methods: Using Cox proportional hazards models, we estimated cancer mortality risks through 2008 according to work history and other data derived from questionnaire responses provided during 1983-89 by 90,268 U.S. radiologic technologists. We controlled for potential confounding by age, birth year, pack-years of cigarettes smoked, body mass index, race, and gender. Results: There were 9,564 deaths and 3,329 deaths from cancer. After controlling for potential confounding factors, we found that technologists who began working before 1950 had marginally increased risk of dying from all cancers (p-trend=0.08), as well as increased risk of dying from female breast cancer (p-trend=0.01) and stomach cancer (p-trend=0.01) compared to those who began working in 1970 or later. Other work history factors, including starting work at a younger age, working greater number of years, or holding patients for x-rays more often, were not consistently associated with increased cancer mortality risks. Conclusions: We found that radiologic technologists who worked before 1950 had increased risk of dying from certain cancers, which may reflect higher occupational radiation exposures before the late 1950s. Note: This abstract was not presented at the meeting. Citation Format: Jason J. Liu, Michele M. Doody, Mark P. Little, D Michal Freedman, Bruce H. Alexander, Cari M. Kitahara, Alice J. Sigurdson, Terrence Lee, Preetha Rajaraman, Jeremy S. Miller, Diane M. Kampa, Steven L. Simon, Dale L. Preston, Martha S. Linet. Work history and cancer mortality risks in 90,268 United States radiologic technologists. [abstract]. In: Proceedings of the 105th Annual Meeting of the American Association for Cancer Research; 2014 Apr 5-9; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2014;74(19 Suppl):Abstract nr 281. doi:10.1158/1538-7445.AM2014-281
25 Years of School-Based Health CentersRussian Physicians Helped to Upgrade Medical SkillsAging Research on the International AgendaHELP Network Says Firearms Data Gap Makes Reducing Gun Injuries More DifficultMiscellanea Medica25 Years of School-Based Health CentersRussian Physicians Helped to Upgrade Medical SkillsAging Research on the International AgendaHELP Network Says Firearms Data Gap Makes Reducing Gun Injuries More DifficultMiscellanea Medica
Authors: M J Friedrich
Journal: JAMA (1999)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Neighborhoods and Health
Authors: G. M. Sacajiu
Journal: JAMA (2003)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Studies &lt;italic&gt;In Vitro, In Vivo&lt;/italic&gt;, and by Electron Microscope of a Virus Recovered From a C3H Mouse Mammary Tumor: Relationship to Polyoma Virus&lt;xref ref-type="fn" rid="FN1"&gt;2&lt;/xref&gt;&lt;xref ref-type="fn" rid="FN2"&gt;3&lt;/xref&gt;
Authors: A F Howatson, E A McCULLOCH, J D Almeida, L Siminovitch, A A Axelrad, A W Ham
Journal: JNCI Journal of the National Cancer Institute (1960)

Previous studies indicated that a virus we recovered in tissue culture from a C3H mouse mammary tumor had some effects in mice and hamsters that were similar to and others dissimilar from those of the polyoma virus. To clarify the relationship between these two viruses, further studies in vitro, in vivo, and with the electron microscope were made and are reported here. An important finding from the studies in vitro was that the two viruses were indistinguishable by hemagglutination inhibition tests. The studies in vivo related chiefly to the effects of the virus in rats; this had not previously been determined. Our virus was found to be much more pathogenic for this species than the polyoma virus was. Finally, electron-microscope studies were made on hamster kidneys 5 to 7 days after infection; previous light-microscope studies had shown that the necrotizing effect of the virus was then at its peak. These studies revealed particles 28 mµ in diameter particularly in the nuclei and in phagocytosed material in the cytoplasm of medullary stromal cells. Similar particles were found in nuclei of cells in which the virus was being propagated, and a few were occasionally seen in the nuclei of cells of parotid tumors induced in mice by the virus. These particles probably represent the virus responsible for the tumors; their morphology is similar to that described by others for the polyoma virus. The significance of larger viruslike particles observed in some of the tumors induced in mice is discussed. The conclusion from all our studies is that the virus recovered from the C3H mammary carcinoma belongs to the polyoma family. However our virus preparations are less carcinogenic for mice and more carcinogenic for hamsters and rats than the polyoma virus recovered by Stewart, Eddy et al. These differences suggest that the virus recovered in our laboratory is a variant of the polyoma virus.
Abstract 17930: Indices of Adiposity and Subclinical Cardiovascular Disease: the Jackson Heart Study(JHS)
Authors: Adedotun A Ogunsua, Akintunde O Akinkuolie, Olulade A Ayodele, Jiankang Liu, DeMarc Hickson, Herman A Taylor, Philimon Gona, Robert Goldberg, Cheryl Clark
Journal: Circulation (2014)

Background: Evidence that indices of adiposity, which better account for central obesity, outperform body mass index (BMI) in discriminating presence versus absence of cardiovascular disease (CVD) are largely derived from Caucasian populations with limited and inconsistent findings in African Americans (AA). Characterization of the optimal measure of adiposity for improving CVD risk prediction and stratification in AAs is needed. Aim: We cross-sectionally evaluated the performance of BMI, waist circumference (WC), % body fat (%BF), waist to height ratio (WHtR), visceral adipose tissue (VAT), and subcutaneous adipose tissue (SAT) in predicting the presence of subclinical CVD as defined by coronary artery calcification (CAC) and abdominal aorta calcification (AAC) in the JHS, a cohort of AAs. Methods: 2,253 participants (66% female, mean age: 55 years) with no prior CVD were studied. VAT, SAT, CAC and AAC were determined using CT scan, %BF was assessed with bioelectric impedance and other adiposity indices were measured using standard protocols. Logistic regression models were constructed and c statistic from receiver operating characteristic curve was used to assess the utility of each adiposity index in predicting CAC and AAC. Results: Prevalence of CAC and AAC were 43% and 63% respectively. In univariate analyses with CAC as outcome, c statistic for VAT, WHtR, WC, %BF, SAT and BMI ranged from 0.60-0.51 in decreasing order, and were statistically significantly higher when compared with BMI, except SAT and %BF. Similar results were noted for AAC. However, none of the indices improved risk discrimination beyond traditional CVD risk factors (Table). Conclusion: VAT had the highest discrimination capacity for subclinical CVD followed by WHtR and WC. These results suggest that though other adiposity measures performed slightly better than BMI, none of the measures contributed significantly to discriminating subclinical CVD beyond the traditional CVD risk factors.
Trends in Basal Cell Carcinoma Incidence and Identification of High-Risk Subgroups, 1998-2012
Authors: Maryam M. Asgari, Howard H. Moffet, G. Thomas Ray, Charles P. Quesenberry
Journal: JAMA Dermatology (2015)

The incidence of basal cell carcinomas (BCCs) is increasing globally, but incidence rates in the United States are difficult to quantify because BCCs are not reportable tumors.To estimate annual BCC incidence rates by age, sex, and race/ethnicity to identify demographically distinct high-risk subgroups and to assess changes in rates over time.In this retrospective cohort study (January 1, 1998, through December 31, 2012), we studied 147 093 patients with BCC from Kaiser Permanente Northern California, a large, integrated health care provision system, identified using a previously validated BCC registry.We estimated annual BCC incidence rates by age, sex, and race/ethnicity and assessed changes in rates over time. The BCC incidence rates were standardized to the age, sex, and race/ethnicity distribution of the 2010 US Census population.In models adjusting for age, sex, and race, male patients had higher rates than female patients (incidence rate ratio [IRR], 1.65; 95% CI, 1.60-1.70). Persons 65 through 79 years of age and those 80 years and older had higher rates than persons 40 through 64 years of age (IRR, 2.96; 95% CI, 2.86-3.06; and IRR, 5.14; 95% CI, 4.94-5.35, respectively). Whites had higher rates than multiracial persons (IRR, 1.96; 95% CI, 1.80-2.13), Hispanics (IRR, 8.56; 95% CI, 7.79-9.41), Asians (IRR, 33.13; 95% CI, 27.84-39.42), and blacks (IRR, 72.98; 95% CI, 49.21-108.22).We estimate that BCCs occur in approximately 2 million Americans annually. Our findings provide an updated estimate of the incidence of BCCs, highlight the changing epidemiologic findings, and better identify demographically distinct high-risk subgroups.
Disease Detectives Celebrate 50 Years of Successful Sleuthing
Authors: B Vastag
Journal: JAMA (2001)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Diagnostic Nuclear Medicine.
Authors: Martin P. Sandler
Journal: Annals of Internal Medicine (1991)

This volume covers recent advances in imaging technology and radiopharmaceutical development that are changing nuclear medicine practice. It includes the latest information on: cardiology; single photon emission computed tomography (SPECT); positron emission tomography (PET); radio pharmaceuticals for the heart and brain; use of pharmaceutical agents to stress patients for cardiac exams; advances in transplant medicine; and use of monoclonal antibodies. Material is arranged by organ systems to reflect the way patients are seen in practice.
After the Madness of Saigon
Authors: Walt McDonald
Journal: JAMA (1998)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Angiogenic revascularisation in ischaemic disease
Authors: N. P J Brindle, M. J McCarthy, P. R F Bell
Journal: BMJ (1999)

Clinical review p 1536 

The advantages of being able to revascularise ischaemic tissue by inducing the formation of new blood vessels without performing a bypass graft or angioplasty are clear. In the past few months several reports of the first experimental applications of this angiogenic therapy in patients have appeared and are reviewed in detail by Henry on p 1536.1 Angiogenic therapy is some way off widespread clinical application, but it is possible to see what needs to be done for it to become a viable alternative to surgery.

Angiogenesis involves activating normally quiescent endothelial cells, causing them to sprout off existing microvessels and, by a coordinated programme involving migration, proliferation, and differentiation, give rise to new vessels.2 Initial activation of this process is under the control of angiogenic growth factors, including members of the family of endothelial specific vascular endothelial growth factors, as well as others, such as platelet derived growth factor and fibroblast growth factor, that can …
Talking With Alan I. Leshner, PhD, National Institute on Drug Abuse Director
Authors: A I Leshner
Journal: JAMA (2001)

BETHESDA, MD—Since Alan I. Leshner, PhD, took the helm of the National Institute on Drug Abuse (NIDA) in 1994, the agency’s annual budget has nearly doubled, to $781 million, supporting much of the world’s research on the biology of addiction, genetic and environmental risk factors, and addiction prevention and treatment. Of the two dozen institutes that comprise the National Institutes of Health (NIH), NIDA is in a unique position. Addiction is, arguably, more politicized than any other medical issue, putting Leshner and his views under a spotlight. He is quoted almost weekly in major newspaper and magazine articles as the authority on the subject. Such visibility comes with a price, though, as Leshner has been attacked on all fronts—for being both too soft and too harsh on drug issues. Before joining NIDA, Leshner enjoyed a highly regarded research career, which largely focused on the biology of behavior. He has also served as acting director of the National Institute of Mental Health (NIMH) and earlier worked at the National Science Foundation, Bucknell University, the Postgraduate Medical School in Budapest, Hungary, and the Wisconsin Regional Primate Research Center in Madison. He has a PhD in physiological psychology. JAMA: I’ve heard you say that one of the things you’d like to do is “change the national discourse” about illicit drug abuse and addiction. Does this mean making addiction more of a medical problem and less of a criminal problem? Dr Leshner: No, no. I am ferociously against polarizing the debate. I think that’s one of the terrible problems we’ve made with this issue. People say that it’s either a public health or a public safety issue. The truth is, it’s both. And it begins with a voluntary behavior: people choose to use drugs. I don’t call it morality, but I call it voluntary. And there’s no question it’s a medical illness and once you have it, it mandates
Abstract 15758: High Intensity Focused Ultrasound Can Produce Noninvasive Myocardial Infarction in Mice
Authors: Chad Walton, Nikki Castel, Ralph V Shohet
Journal: Circulation (2014)

High Intensity Focused Ultrasound (HIFU) can destroy biological tissue at specific focal depths without affecting intervening anatomical structures. We have used a custom ultrasound instrument coupled to a stereotactic targeting frame, in a non-surgical, external application of a 1.1 MHz HIFU transducer in order to target the aortic root to disrupt blood flow in the Left Anterior Descending coronary artery, effectively inducing a myocardial infarction. The optimized ultrasound parameters include 20 cycles with an energy equaling a mechanical index (MI) of ~13. This flexible and customizable HIFU-based ultrasound platform permits a more physiological infarction model in mice than is presently available using invasive surgical techniques. The advantages of this approach include avoiding the trauma of intubation, thoracotomy, and direct manipulation of the heart. We expect that this approach will improve the speed of recovery, reduce mortality, and more closely recapitulate the situation of myocardial infarction in human patients. Recognizing the novelty of the method we compared it to conventional LAD ligation. This new technique produces similar infarctions, evaluated by ECG, echocardiography, and histology. This nonsurgical approach to myocardial infarction should be useful in a broad range of cardiac investigations.
Preleukemic state of adult T cell leukemia: abnormal T lymphocytosis induced by human adult T cell leukemia-lymphoma virus
Authors: K Kinoshita, T Amagasaki, S Ikeda, J Suzuyama, K Toriya, K Nishino, M Tagawa, M Ichimaru, S Kamihira, Y Yamada
Journal: Blood (1985)