Pulmonary Alveolar Microlithiasis—A Family Study
Authors: R P O'Neill, J E Cohn, E D Pellegrino
Journal: Annals of Internal Medicine (1967)

Article1 November 1967Pulmonary Alveolar Microlithiasis—A Family StudyRICHARD P. O'NEILL, M.D., JEROME E. COHN, M.D., F.A.C.P., EDMUND D. PELLEGRINO, M.D., F.A.C.P.RICHARD P. O'NEILL, M.D.Search for more papers by this author, JEROME E. COHN, M.D., F.A.C.P.Search for more papers by this author, EDMUND D. PELLEGRINO, M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-67-5-957 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptPulmonary alveolar microlithiasis is a rare disorder characterized by small calcific concretions in the alveoli. The classical description of the disease was given by Harbitz (1) in 1918, and the presently accepted terminology was suggested in 1933 by Puhr (2). In 1957 Sosman, Dodd, Jones, and Pillmore (3) reported 23 new cases, reviewed 21 cases previously published, and emphasized the tendency of the disease to be familial. Additional cases have been recorded, bringing the total to more than 70 cases.The present report describes studies of pulmonary physiology and calcium metabolism in three siblings with the disease who were among...References1. HARBITZ F: Extensive calcification of lungs as distinct disease. Arch. Intern. Med. (Chicago) 21: 139, 1918. CrossrefGoogle Scholar2. PUHR L: Microlithiasis alveolaris pulmonum. Virchow. Arch. Path. Anat. 290: 156, 1933. CrossrefGoogle Scholar3. SOSMANDODDJONESPILLMORE MDGDWDGU: The familial occurrence of pulmonary alveolar microlithiasis. Amer. J. Roentgen. 77: 947, 1957. Google Scholar4. KORYCALLAHANBORENSYNER RCRHGJC: Veterans Administration-Army cooperative study of pulmonary function. 1. Clinical spirometry in normal men. Amer. J. Med. 30: 243, 1961. CrossrefMedlineGoogle Scholar5. 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BIRESSICASASSA PCPM: Intra-alveolar pulmonary microlithiasis. Minerva Med. 47: 930, 1956. MedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Lexington, KentuckyFrom the Department of Medicine, College of Medicine, University of Kentucky, Lexington, Ky.Requests for reprints should be addressed to Richard P. O'Neill, M.D., Department of Medicine, University of Kentucky Medical Center, Lexington, Ky. 40506.†Deceased. 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