HEPATOLENTICULAR DEGENERATION (WILSON'S DISEASE); REPORT OF ONE CASE WITH SEVERE PORTAL CIRRHOSIS AND SPLENOMEGALY
Authors: Harry Freedberg
Journal: Annals of Internal Medicine (1945)

Case Reports1 March 1945HEPATOLENTICULAR DEGENERATION (WILSON'S DISEASE); REPORT OF ONE CASE WITH SEVERE PORTAL CIRRHOSIS AND SPLENOMEGALYHARRY FREEDBERG, M.D.HARRY FREEDBERG, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-22-3-418 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptIn 1912 Kinnier Wilson described a series of 13 cases of extrapyramidal disease associated with liver cirrhosis. His original description was as follows: "This disease which occurs chiefly in young people, often familial but not congenital or hereditary, is characterized by involuntary movements, dysarthria, muscular weakness, spasticity, contractures, progressive emaciation, mental deterioration and frequent emotional disturbances. This disease is progressive and, after a longer or shorter period, fatal." Since then sporadic cases have been reported in the literature.Many hypotheses have been advanced as to the etiology of the disease and chief among the reviews has been that of Jervis....Bibliography WAGGONERMALMUD RWN: Wilson's disease in the light of cerebral changes following ordinary acquired liver disorders, Jr. Nerv. and Ment. Dis., 1942, xcvi, 410. CrossrefGoogle Scholar STOCKER W: Ein Fall von fortschreitender Lenticulardegeneration, Ztschr. f. d. ges. Neurol. u. Psychiat., 1913, xv, 251. CrossrefGoogle Scholar WILSON SA: Progressive lenticular degeneration, Brain, 1912, xxxiv, 295. CrossrefGoogle Scholar SWEETGRAYALLER WHSJJG: Clinical detection of hepatic disease in hepatolenticular degeneration, Jr. Am. Med. Assoc., 1941, cxvii, 1613. CrossrefGoogle Scholar FARNELLHARRINGTON FJAH: Progressive lenticular degeneration (with exhibition of lantern slides, Jr. Nerv. and Ment. Dis., 1916, xliii, 460. CrossrefGoogle Scholar HOWARDROYCE CPCE: Progressive lenticular degeneration associated with cirrhosis of the liver (Wilson's disease), Arch. Int. Med., 1919, xxiv, 497. CrossrefGoogle Scholar GOODHARTBALSERBIEBER SPBHI: Encephalographic studies in cases of extrapyramidal disease, Arch. Neurol. and Psychiat., 1936, xxxv, 240. CrossrefGoogle Scholar WILSON SA: Progressive lenticular degeneration, Neurology, Vol. 2, 1940, Williams & Wilkins, Baltimore, p. 811. Google Scholar BARNESHURST SEW: Hepato-lenticular degeneration, Brain, 1925, xlviii, 279. CrossrefGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Salem, Massachusetts*Received for publication September 13, 1943. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byToxische OsteopathienToxische OsteopathienOsteoarthropathy of hepatolenticular degenerationWilson’s DiseaseLiver dysfunction in hepatolenticular degeneration 1 March 1945Volume 22, Issue 3Page: 418-425KeywordsCirrhosisEmotionsEtiologyGenetic diseasesLiver diseasesMuscular diseasesMuscular weaknessProgressive diseasesSplenomegaly ePublished: 1 December 2008 Issue Published: 1 March 1945 PDF downloadLoading ...