CHLOROTHIAZIDE AND HYDROCHLOROTHIAZIDE: A COMPARATIVE STUDY OF THEIR HYPOTENSIVE, SALURETIC AND HYPERURICEMIC ACTION
Authors: N O BORHANI
Journal: Annals of Internal Medicine (1960)

Article1 August 1960CHLOROTHIAZIDE AND HYDROCHLOROTHIAZIDE: A COMPARATIVE STUDY OF THEIR HYPOTENSIVE, SALURETIC AND HYPERURICEMIC ACTIONNEMAT O. BORHANI, M.D.NEMAT O. BORHANI, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-53-2-342 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptINTRODUCTIONThe synthesis of chlorothiazide by Novello and Sprague1and the discovery of its favorable saluretic action2, 18, 19introduced a unique type of pharmaceutic agent to the management of cardiovascular diseases. Chlorothiazide (Diuril), a heterocyclic sulfonamyl compound (figure 1A) is an orally effective diuretic, useful in the treatment of congestive heart failure and other edematous conditions. In addition, this drug has some antihypertensive properties, and usually augments the antihypertensive activity of sympathetic depressor agents. It has been claimed that chlorothiazide, by virtue of its activity as a carbonic anhydrase inhibitor, induces natruresis and kaluresis, and causes the excretion of...Bibliography1. NovelloSprague FCJM: Benzothiadiazine dioxides as novel diuretics, J. Am. Chem. Soc. 79: 2028, 1957. CrossrefGoogle Scholar2. BeyerBaerRussoNoll KHJEHFR: Electrolyte excretion as influenced by chlorothiazide, Science 127: 146, 1958. CrossrefMedlineGoogle Scholar3. Pitts RF: Some reflections on mechanism of action of diuretics, Am. J. Med. 24: 745, 1958. CrossrefMedlineGoogle Scholar4. PittsKruckLazanoTaylorHeidenreichKessler RFFRDWOPRH: Studies in the mechanism of diuretic action of chlorothiazide, J. Pharmacol. and Exper. Therap. 123: 89, 1957. Google Scholar5. HeinemanDemartiniLaragh HOFEJH: The effect of chlorothiazide on renal excretion of electrolytes and free water, Am. J. Med. 26: 853, 1959. CrossrefMedlineGoogle Scholar6. Ford RV: The clinical pharmacology of hydrochlorothiazide, South. M. J. 52: 40, 1959. CrossrefMedlineGoogle Scholar7. Grollman A: A unitary concept of experimental and clinical hypertensive cardiovascular disease, Perspectives in Biol. and Med. 2: 208, 1959. CrossrefMedlineGoogle Scholar8. Snedecor GW: Statistical methods, 1956, The Iowa State College Press, Ames, Iowa. Google Scholar9. Cornfield J: Personal communication. Google Scholar10. Scheffé H: A method for judging all contrasts in the analysis of variance, Biometrika 40: 87, 1953. Google Scholar11. JanuszewiczHeinemanDemartiniLaragh WHOFEJH: A clinical study of hydrochlorothiazide on the renal excretion of electrolytes and free water, New England J. Med. 261: 264, 1959. CrossrefMedlineGoogle Scholar12. CorcoranMacleodDustanPage ACCHPIH: Effects of chlorothiazide on specific renal function in hypertension, Circulation 19: 355, 1959. CrossrefMedlineGoogle Scholar13. OrenRichBelle BGMMS: Chlorothiazide (Diuril) as a hyperuricacidemic agent, J. A. M. A. 168: 2128, 1958. CrossrefMedlineGoogle Scholar14. LaraghHeinemanDemartini JHHOFE: Effect of chlorothiazide on electrolyte transport in man: its use in treatment of edema of congestive heart failure, nephrosis and cirrhosis, J. A. M. A. 166: 145, 1958. CrossrefMedlineGoogle Scholar15. MonroeGrantSasaharaLittmann KELHAAD: Effect of chlorothiazide therapy on serum uric acid and uric acid excretion, New England J. Med. 261: 290, 1959. CrossrefMedlineGoogle Scholar16. DolleryHarringtonKaufmann CTMG: The mode of action of chlorothiazide in hypertension, Lancet 1: 1215, 1959. CrossrefMedlineGoogle Scholar17. FlemingZilvaBaylissPirkis PRJFRIJ: Hydrochlorothiazide. A comparison with chlorothiazide, Lancet 1: 1218, 1959. CrossrefMedlineGoogle Scholar18. BeyerBaerRussoHaimbach KHJEHFA: Chlorothiazide, the enhancement of sodium chloride excretion, Federation Proc. 16: 282, 1957. Google Scholar19. Beyer KH: Mechanism of action of chlorothiazide, Ann. New York Acad. Sc. 71: 363, 1958. CrossrefMedlineGoogle Scholar20. Harington M: Effect of chlorothiazide on the hypotensive action of mecamylamine and on its urinary excretion, Lancet 1: 403, 1958. CrossrefMedlineGoogle Scholar21. HussbaumLeffMattiaHillman HEWAVDE: Fixed combination of chlorothiazide-reserpine in hypertension, Am. J. M. Sc. 236: 786, 1958. CrossrefMedlineGoogle Scholar22. Wilkins RW: New drugs for hypertension with special reference to chlorothiazide, New England J. Med. 257: 1026, 1957. CrossrefMedlineGoogle Scholar23. HollanderChobanianWilkins WAVRW: Studies on the antihypertensive action of chlorothiazide, Clin. Res. 6: 21, 1958. Google Scholar24. WilsonFreis IMED: Extracellular fluid and plasma volume changes in non-edematous hypertensives after prolonged treatment with chlorothiazide, Circulation 18 (Part II): 800, 1958. Google Scholar25. BaerBeyerRussoTitus JHKHHFDC: Renal tubular secretion of chlorothiazide, Federation Proc. 17: 346, 1958. Google Scholar26. YuGutman TFAB: Paradoxical retention of uric acid by uricosuric drugs in low dosage, Proc. Soc. Exper. Biol. and Med. 90: 542, 1955. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Baltimore, Maryland*Received for publication March 29, 1960.Presented at the Forty-first Annual Session of The American College of Physicians, San Francisco, California, April 5, 1960.From the Hypertension Clinic, the Joseph Earl Moore Clinic, Johns Hopkins Hospital; the Department of Medicine, Johns Hopkins University School of Medicine, and Division of Chronic Diseases, Johns Hopkins School of Hygiene and Public Health, Baltimore, Maryland.†This study was supported in part by the grant HT5082 from the National Heart Institute, National Institutes of Health, U. S. Public Health Service.Requests for reprints should be addressed to Nemat O. Borhani, M.D., Special Consultant to Bureau of Chronic Diseases, State of California, Department of Public Health, 2151 Berkeley Way, Berkeley 4, California. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byDiuretic Strategies for Loop Diuretic Resistance in Acute Heart FailureComparison of the Effects of Combination Diuretic Therapy with Oral Hydrochlorothiazide or Intravenous Chlorothiazide in Patients Receiving Intravenous Furosemide Therapy for the Treatment of Heart FailureDose-response relationships with antihypertensive drugsDiuretic drugs in hypertensionClinical Pharmacology of Antihypertensive Drug TherapyKlinische Pharmakologie der antihypertensiven PharmakotherapieAntihypertensive Effect of DiureticsDauertherapieRenal mechanisms for regulation of uric acid excretion, with special reference to normal and gouty manThiazide Diuretics and Related DrugsPharmacology of diureticsDisturbances in carbohydrate and uric-acid metabolism during diuretic treatmentHyperuricemia induced by the administration of chlorthalidone and other sulfonamide diureticsZoxazolamine as a Uricosuric Agent 1 August 1960Volume 53, Issue 2Page: 342-358KeywordsAttentionExcretionHospital medicineHygieneHypertensionLongitudinal studiesMedical servicesPrevention, policy, and public healthUreaUric acid ePublished: 1 December 2008 Issue Published: 1 August 1960 PDF downloadLoading ...