tbuckley/cabot-search huggingface dataset:
CT, MRI Scans Offer New Tools for Autopsy
Authors: Mike Mitka
Journal: JAMA (2007)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Ablation of Peripheral Dopaminergic Nerves Stimulates Malignant Tumor Growth by Inducing Vascular Permeability Factor/Vascular Endothelial Growth Factor-Mediated Angiogenesis
Authors: Sujit Basu, Chandrani Sarkar, Debanjan Chakroborty, Janice Nagy, Rita Basu Mitra, Partha Sarathi Dasgupta, Debabrata Mukhopadhyay
Journal: Cancer Research (2004)

Abstract Many important physiological and pathological processes are modulated by angiogenesis. It has been shown that initiation of this angiogenic process is an essential early step in the progression of malignant tumors. We report here that ablation of peripheral dopaminergic nerves markedly increased angiogenesis, microvessel density, microvascular permeability, and growth of malignant tumors in mice. Endogenous peripheral dopamine acted through D2 receptors as significantly more angiogenesis and tumor growth was observed in D2 dopamine receptor knockout mice in comparison with controls. The vascular endothelial growth factor receptor 2 phosphorylation, which is critical for promoting angiogenesis, was also significantly more in tumor endothelial cells collected from the dopamine-depleted and D2 dopamine receptor knockout animals. These results reveal that peripheral endogenous neurotransmitter dopamine might be an important physiological regulator of vascular endothelial growth factor-mediated tumor angiogenesis and growth and suggest a novel link between endogenous dopamine, angiogenesis, and tumor growth.
Deposition of hepatitis B e antigen in membranous glomerulonephritis: Identification by F(ab′)2 fragments of monoclonal antibody
Authors: Hiroshi Hirose, Kazumichi Udo, Mineo Kojima, Yoshiyata Takahashi, Yuzo Miyakawa, Koukichi Miyamoto, Hiroshi Yoshizawa, Makoto Mayumi
Journal: Kidney International (1984)
Analysis of the major epitope of the α2 chain of bovine type I collagen in children with bovine gelatin allergy
Authors: Hisae Hori, Shunji Hattori, Sakae Inouye, Akinori Kimura, Shinkichi Irie, Hiroshi Miyazawa, Masahiro Sakaguchi
Journal: Journal of Allergy and Clinical Immunology (2002)
Do tertiary paediatric hospitals deal with the same spectrum of paediatric pulmonary hypertension as multicentre registries?
Authors: Marilyne Lévy, David Celermajer, Isabelle Szezepanski, Younes Boudjemline, Damien Bonnet
Journal: European Respiratory Journal (2012)

72 UI).Treatment with corticosteroids was impossible because of the patient's psychiatric instability.Hydroxychloroquine treatment (400 mg?day -1 ) was then initiated.A significant, but only partial, clinical, radiological and functional improvement ensued, with a secondary relapse despite good observance.
Instrumental aspects of positive and negative ion chemical ionization mass spectrometry.
Authors: G C Stafford
Journal: Environmental Health Perspectives (1980)

Differences in recording positive and negative ion chemical ionization mass spectra on a quadrupole mass spectrometer are discussed. An analog positive and negative ion electron multiplier detector is described which is well suited for a quadrupole instrument. This detector significantly reduces baseline noise in the negative ion mode and improves positive ion high mass sensitivity.
Interleukin-13 expression in the nasal mucosa of perennial allergic rhinitis.
Authors: R U Pawankar, M Okuda, S Hasegawa, K Suzuki, H Yssel, K Okubo, K Okumura, C Ra
Journal: American Journal of Respiratory and Critical Care Medicine (1995)

Allergic rhinitis is an IgE mediated atopic disease characterized by elevated levels of allergen specific IgE antibodies that play a central role in mediating allergic reactions. Interleukin 13 (IL-13) is a novel T-cell-derived cytokine that shares several functional properties with IL-4 and has been demonstrated to be capable of inducing IgE synthesis. The present study was designed to investigate the expression of IL-13 gene in the epithelial compartment of the nasal mucosa of patients with perennial allergic rhinitis (PAR) to house dust mite, comparing it with that in the nasal epithelial compartment of chronic infectious rhinitis (CIR) patients and normal volunteers (NV). We also investigated the IL-13 gene expression in the peripheral blood of PAR patients. Nasal scrapings were collected from the inferior turbinate of patients undergoing conchotomy surgery and from outpatients, and the mRNA expression of IL-13 was analyzed by the RT-PCR method. Peripheral blood mononuclear cells were isolated by density-gradient centrifugation and the expression of IL-13 gene was examined by the RT-PCR method. IL-13 expression at protein level and its cell source were analyzed by immunohistochemistry of inferior turbinate biopsies. The levels of total serum IgE and allergen-specific IgE antibodies in the serum were estimated by the PRIST and CAP RAST method, respectively. IL-13 gene expression was detected in the epithelial compartment of the nasal mucosa of 18/19 PAR patients but was undetected in normal volunteers and CIR patients.(ABSTRACT TRUNCATED AT 250 WORDS)
840 EFFICACY AND SAFETY OF PEGINTERFERON ALFA-2a OR -2b PLUS RIBAVIRIN IN THE ROUTINE DAILY TREATMENT OF CHRONIC HEPATITIS C PATIENTS IN GERMANY: THE PRACTICE STUDY
Authors: T. Witthoeft, D. Hueppe, C. John, J. Goelz, U. Meyer, R. Heyne, B. Moeller, R. Link, G. Teuber, S. Sworszt, A. Herrmann, A. Wollschlaeger, A. Baumgarten, K.G. Simon, H.-J. Cordes, G. Moog, N. Dikopoulos, S. Mauss
Journal: Journal of Hepatology (2008)
The injustice of compensation for victims of medical accidents
Authors: J. Harris
Journal: BMJ (1997)

In most healthcare systems the need to prioritise patients for care and to ration the resources available is now well recognised. Almost the only room left for argument is how to prioritise fairly and where to make the deepest cuts. However, one group of claimants for healthcare resources have been guaranteed top priority for receipt of funds available for health care–victims of medical accidents. This fact has been scarcely noted and its justice seldom questioned.

In the United Kingdom and in many other public healthcare systems successful claims for medical negligence against hospitals or doctors are settled from the health budget and use resources that would otherwise be spent on health care. About 80% of all medical accidents occur in hospitals. In the United Kingdom in 1993-4 the resulting claims were estimated to be £125m ($200m),1 and projections for the remainder of this century are between £250m and £1000m (K Haynes, conference of the Institute of Medicine, Law and Bioethics, Liverpool, April 1996).

Until the introduction of NHS indemnity in January 1990 the cost of any compensation award against a hospital doctor was shared between the NHS and the doctor's medical defence organisation. And until 1995, when the clinical negligence scheme for trusts was introduced, hospitals effectively insured themselves against claims. But now all hospital negligence claims are paid for by the NHS, reducing the amount available for all other health expenditure.1 2

When judgment is delivered by the courts payment becomes due immediately and hospitals have to pay the compensation awarded against them. Thus successful litigants get immediate and absolute priority in the deployment of public resources allocated for health. This guarantee of access to health resources for successful litigants highlights an important ambiguity when allocation decisions are based on scarcity. When a particular patient's life cannot …
Hydrogen peroxide induced impairment of post-ischemic ventricular function is prevented by the sodium–hydrogen exchange inhibitor HOE 642 (cariporide)
Authors: M Myers
Journal: Cardiovascular Research (1998)

Objective: Sodium–hydrogen exchange (NHE) activation is a major mechanism of cardiac injury produced by ischemia and reperfusion. In addition, NHE may mediate the direct effects of hydrogen peroxide (H2O2) in normally perfused hearts. The present study was done to determine whether H2O2 at low concentrations producing mild myocardial depression affects post-ischemic recovery of function and to determine the ability of the NHE inhibitor HOE 642 to modulate this effect. Methods: Isolated Langendorff-perfused rat hearts with a left ventricular balloon inflated to an initial end-diastolic pressure of 5 mmHg were subjected to 90 min of global zero-flow ischemia followed by 60 min reperfusion. In Study 1, hearts were randomized for perfusion with or without H2O2 (20 μM) for 15 min before ischemia and throughout reperfusion. In Study 2, identical experiments were done except that the hearts were pretreated with the NHE inhibitor HOE 642 (5 μM). Function was assessed by determining intraventricular pressures. Results: Recovery of developed pressure in Study 1 after 10 min reperfusion was 60.3±8% of pre-ischemic values in control hearts whereas this was reduced to 29.9±10% in hearts treated with H2O2 (P<0.05). After 60 min of reperfusion recovery of developed pressure was 80.3±5.2% and 60.7±7% in control and H2O2-treated hearts, respectively (P<0.05). Recovery of rates of pressure development (+dP/dt) and relaxation (−dP/dt) paralleled the effects seen with developed pressure. Moreover, these effects were associated with significantly elevated end-diastolic pressure during the last 20 min of reperfusion. In Study 2, HOE 642 completely prevented the deleterious effect of H2O2, both with respect to ventricular recovery and to the elevation in end-diastolic pressure during reperfusion. Conclusions: Our results show that very low concentrations of H2O2 significantly impair recovery of function in this rat model of myocardial ischemia–reperfusion. Moreover, our results suggest that this effect is likely dependent on NHE activity and can be prevented by treatment with the NHE inhibitor HOE 642.
1045 SAFETY AND ANTIVIRAL EFFICACY OF 14 DAYS OF THE CYCOPHILIN INHIBITOR NIM811 IN COMBINATION WITH PEGYLATED INTERFERON α2a IN RELAPSED GENOTYPE 1 HCV INFECTED PATIENTS
Authors: E. Lawitz, R. Rouzier, T. Nguyen, M. Huang, J. Ke, J. Praestgaard, D. Serra, M. Koziel, T. Evans
Journal: Journal of Hepatology (2009)
Transparent Development of WHO Rapid Advice Guidelines: A Useful Approach
Authors: Antonio Cunha
Journal: PLoS Medicine (2007)

a former collaborator of the Faculty of Medicine of the Mozambican Eduardo Mondlane University, I have been screaming the same message as Ooms and collegues [1] for years now.I am glad that fi nally some attention has been given to this fact.Although I do agree with the general message of the article, in the case of Mozambique, the brain drain is not the biggest problem.Neither are the salaries.It's the pure lack of doctors.Only up to 60 doctors a year are trained at the University for a population of 18 million.In 2004, Mozambique had about 700 medical doctors, expatriates from all nongovernmental organizations and projects included.I do not agree that increasing salaries would be the most effi cient solution.This will not create more doctors.This will create salaries without doctors.The Mozambican Ministry of Health received hundred of millions of dollars from international donors for the National AIDS Plan, while the Faculty of Medicine, dependant on the Ministry of Education, was struggling to survive.Not a single dollar from all the AIDS millions went to support the basic education of doctors.Not out of bad will, but because donors have too many restrictions.Doctors are not only needed for the HIV/AIDS epidemicthey also treat the many cases of malaria, tuberculosis, diarrhea in children, leishmaniasis, fi stula, sexually transmitted infections...They perform caesarean sections and other life-saving surgeries.It's my strong opinion that direct investment in training of medical doctors is the most effective sector-wide approach in public health.It is the most obvious and well-defi ned contribution to the health-related Millennium Development Goals and development in general.I do not understand why so few donors agree with this.I can only speak for the case of Mozambique.
Migratory Multiple Bone Involvement in a Patient with Systemic Mastocytosis
Authors: COBI LIDOR, TOM HALLEL, VICTOR 0. OREN
Journal: Clinical Nuclear Medicine (1990)

A young patient with severe generalized osteopenia and multiple compressed vertebral fractures caused by systemic mastocytosis is presented. Extensive clinical, laboratory, and pathologic examination showed the involvement of the skeleton alone. Follow-up bone scintigraphy with Tc-99m MDP during a period of 6 years demonstrated migratory multiple axial lesions. These results suggest that Tc-99m MDP imaging is an accurate detection of the activity of the disease.
Labels for Prescribed Drugs
Authors: John H. Dirckx
Journal: JAMA (1979)

<h3>To the Editor.—</h3> Dosage errors made by patients taking prescription medications are usually blamed on ignorance or carelessness. I suspect that many such errors result from the way that pharmacists apply labels to prescription bottles. Presently, nearly all medications prescribed for adults come in tablets or capsules that are almost universally dispensed in cylindrical plastic bottles. Customarily, the label is so placed that the lines of writing wrap around the circumference of the bottle. Unless this circumference is at least three times the width of the label, part of each line of directions is out of view no matter how the bottle is held. To read the label of a typical prescription bottle, one must rotate it through a substantial arc for each line of writing and then rotate it back for the start of the next line. Even an alert, intelligent, practiced reader with good visual acuity finds the
Recurrence of classical juvenile pityriasis rubra pilaris in adulthood: report of a case
Authors: J-B. Hong, H-C. Chiu, S-H. Wang, T-F. Tsai
Journal: British Journal of Dermatology (2007)

Journal Article Recurrence of classical juvenile pityriasis rubra pilaris in adulthood: report of a case Get access J‐B. Hong, J‐B. Hong Department of Dermatology, National Taiwan University Hospital and National Taiwan University College of Medicine, No. 7, Chun‐Shan South Road, Taipei 100, Taiwan Search for other works by this author on: Oxford Academic Google Scholar H‐C. Chiu, H‐C. Chiu Department of Dermatology, National Taiwan University Hospital and National Taiwan University College of Medicine, No. 7, Chun‐Shan South Road, Taipei 100, Taiwan Search for other works by this author on: Oxford Academic Google Scholar S‐H. Wang, S‐H. Wang Department of Dermatology, National Taiwan University Hospital and National Taiwan University College of Medicine, No. 7, Chun‐Shan South Road, Taipei 100, Taiwan Search for other works by this author on: Oxford Academic Google Scholar T‐F. Tsai T‐F. Tsai Department of Dermatology, National Taiwan University Hospital and National Taiwan University College of Medicine, No. 7, Chun‐Shan South Road, Taipei 100, Taiwan Correspondence: Tsen‐Fang Tsai E‐mail: tftsai@yahoo.com Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 157, Issue 4, 1 October 2007, Pages 842–844, https://doi.org/10.1111/j.1365-2133.2007.08126.x Published: 01 October 2007
Electrolyte Imbalance in Tuberculous Meningitis
Authors: S. A. Doxiadis, M. K. Goldfinch, M. G. Philpott
Journal: BMJ (1954)

MEDICAL JOUR~NAL of their mother.The wording suggested was "To live in the hearts of those we love is not to die."This had tremendous emotional significance for the patient, whose feelings of guilt became overwhelming.Next day the symp- toms began. Psychosomatic AssessmentThe major personality features in cases of ulcerative colitis described by other authors are easily recognizable in this patient.She was emotionally immature, particularly in her relationship with a dominant and possessive mother, and the keynote of that relationship was the hostile-dependence which evoked a considerable degree of guilt.Her intelligence was well above average.Environnmental stress situations immediately preceded the onset of symptoms on each occasion.The situations were associated with marriage, proposed marriage, or with a threat to the security of her emotional dependence on her mother, such as the visit of her sister in 1942.It was felt that her desire for marriage and emancipation from her mother's domination was in conflict with her basic person- ality pattern.
Aerosolized Prolastin Suppresses Bacterial Proliferation in a Model of Chronic<i>Pseudomonas aeruginosa</i> Lung Infection
Authors: ANDRÉ M. CANTIN, DONALD E. WOODS
Journal: American Journal of Respiratory and Critical Care Medicine (1999)

High levels of active neutrophil elastase (HNE) are present in the respiratory secretions of patients with cystic fibrosis (CF). We hypothesized that aerosolized Prolastin (alpha1-protease inhibitor or α1PI, purified from human blood) could suppress airway neutrophil inflammation and accelerate bacterial clearance from the lung in a model of chronic Pseudomonas aeruginosa lung infection. Because human α1PI effectively inhibits rat as well as human neutrophil elastase (NE) activity in vitro, we choose to test this hypothesis using a rat agar bead model of chronic P. aeruginosa lung infection. In this model, aerosolized Prolastin significantly decreased elastase activity (p < 0.01), lung neutrophil counts (p < 0.01), and bacterial colony counts (p < 0.01). Prolastin had no direct bactericidal effect on P. aeruginosa in vitro. Lung tissue histopathology revealed a marked decrease in lung inflammation in animals treated with Prolastin. These studies indicate that Prolastin can significantly decrease the elastase burden in the chronically infected lung. In addition, not only does Prolastin suppress lung inflammation, but it also markedly decreases P. aeruginosa density in a rat model of chronic P. aeruginosa lung infection. These data suggest that aerosolized α1PI may represent a useful nonantibiotic adjunct in the treatment and control of infection and inflammation associated with CF lung disease.
First Belgian to use new euthanasia law provokes storm of protest
Authors: R. Watson
Journal: BMJ (2002)

Mario Verstraete, a 39 year old from Ghent, became the first person in Belgium to use the country's new legislation legalising euthanasia and immediately prompted media criticism.

Mr Verstraete, who had multiple sclerosis, died on 30 September after being given an injection by his doctor, just eight days after the law came into force.

Critics, mainly in the Flemish media, claim that the manner of his death did not comply with the procedures set out in the legislation and that his doctor could run the risk of prosecution.

They point out that …
Rapid distribution of tryptophol (3-indole ethanol) to the brain and other tissues.
Authors: E M Cornford, W D Bocash, L D Braun, P D Crane, W H Oldendorf, A J MacInnis
Journal: Journal of Clinical Investigation (1979)

Tryptophol (3-indole ethanol) is a compound which induces sleep, and is formed: (a) in the liver after disulfiram treatment, and (b) by the parasite in trypanosomal sleeping sickness. We prepared, purified, and characterized radiolabeled tryptophol for the purpose of defining its tissue distribution in animals. Tryptophol was found to be highly lipophilic, with an octanol:water partition coefficient of 29.8. Brain extraction, determined after intracarotid injection, was high (brain uptake index = 117 +/- 3.5%), and nonsaturable, suggesting the absence of a carrier system. After intravenous administration, tryptophol distribution to tissues correlated with relative blood flow. More than 85% of the radioactivity remaining in brain 2-5 min after intravenous injection co-migrated with tryptophol standards when analyzed by thin-layer chromatography. Other evidence suggested that tryptophol binds to serum and in vivo may be stripped from serum albumin and taken up by brain in a single capillary transit. Our study suggests that in states such as trypanosomal sleeping sickness or disulfiram treatment, remotely formed tryptophol gains ready access to brain (it is 100% cleared in a single capillary passage), and could thus cause somnolence.
Tuberculosis in a Neighborhood Bar
Authors: Thomas R. Frieden, Timothy R. Sterling, Patricia M. Simone
Journal: New England Journal of Medicine (1996)

To the Editor: In the report of Kline et al. describing an outbreak of tuberculosis among bar patrons (July 27 issue),1 4 of the 14 active tuberculosis cases occurred among patients seronegative for the human immunodeficiency virus who had positive tuberculin tests but normal chest radiographs. This is not a new phenomenon2; among contacts of patients with active tuberculosis on Navy ships, 3 to 25 percent of those whose tuberculin skin tests converted from negative to positive had positive sputum cultures despite having normal chest films and sputum smears.3 Kent et al. obtained daily cultures for one month from . . .
Phenothiazines in early labour.
Authors: D. A. Heath, J. M. McGarry
Journal: BMJ (1967)

BRITIS 363 on 50 tablets per Week.Unlike the two cases reported, however, she had underlying rheumatic carditis.I attempted substitution with dummy tablets, but these were recognized as such immediately, and rejected.It would appear that to an addict only dextromoramide tastes like dextromoramide.Similarly, as with the five cases reported, she develops pain (posteriorly in the base of her right lung) if administration is delayed, and wakes approximately two-hourly for further dosage.She is now a registered addict taking 190 5-mg.tablets per week.-Iam, etc., Yardley, B. A. JuBY. Birmingham. BPhenothiazines in Early Labour SIR,-We read with interest your leading article on sedation in early labour (26 November, p. 1282), in particular the use of perphenazine (Fentazin).We agree that the drug is safe, but would like to report two patients we have recently seen who were treated with perphenazine for hyperemesis gravidarum, and who developed dyskinetic side-effects which in each case led to an initial diagnosis of tetany.A 24-year-old lady on admission was seven and a half weeks pregnant and had had hyperemesis for four weeks.This had been treated with a variety of tablets with no success.Two