PULMONARY INFILTRATION WITH EOSINOPHILIA (PIE SYNDROME)
Authors: W H REEDER, B E GOODRICH
Journal: Annals of Internal Medicine (1952)

Article1 May 1952PULMONARY INFILTRATION WITH EOSINOPHILIA (PIE SYNDROME)WILLIAM H. REEDER, M.D., BEN E. GOODRICH, M.D., F.A.C.P.WILLIAM H. REEDER, M.D., BEN E. GOODRICH, M.D., F.A.C.P.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-36-5-1217 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptOnly recently, unsuspected x-ray evidence of nondescript pulmonary infiltrations has focused attention on Loeffler's syndrome, tropical eosinophilia and related conditions. Fewer than 25 case reports of Loeffler's syndrome were found by Peabody1 in English as recently as 1944. Increased use of chest roentgenography and expanded mass x-ray surveys of the general population should lead to more frequent case reports.Sir William Osler2was probably first to report pulmonary abnormality associated with allergic disease. Then 37 years elapsed before Loeffler's3classic report appeared, and 47 years before tropical eosinophilia was described by Weingarten.4The clinical description by Loeffler5of transient pulmonary...Bibliography1. Peabody JW: Transitory migratory pulmonary infiltrations associated with eosinophilia (Loeffler's syndrome), with report of additional case, Dis. of Chest 10: 391, 1944. CrossrefGoogle Scholar2. Osler W: On the visceral complications of erythema exudativum multiforme, Am. J. M. Sc. 110: 629, 1895. CrossrefGoogle Scholar3. Löffler W: Zur differential Diagnose der Lugeninfiltrierungen, Frühinfiltrate unter besonder Berücksichtigung der Rückbildungszeiten, Beitr. z. Klin. d. Tuberk. 79: 338, 1932. CrossrefGoogle Scholar4. Weingarten RJ: Tropical eosinophilia, Lancet 1: 103, 1943. CrossrefGoogle Scholar5. Löffler W: Die flüchtigen Lungeninfiltrate mit Eosinophilie, Schweiz. med. Wchnschr. 66: 1069, 1936. Google Scholar6. EichwaldSingletary MWV: Transient successive pulmonary infiltrations (Löffler's syndrome), Radiology 46: 258, 1946. CrossrefMedlineGoogle Scholar7. HodesWood PJFC: Eosinophilic lung (tropical eosinophilia), Am. J. M. Sc. 210: 288, 1945. CrossrefGoogle Scholar8. MortonJones PHCC: Tropical eosinophilia with report of a case treated with penicillin, Ann. Int. Med. 31: 1112, 1949. LinkGoogle Scholar9. Frimodt-MollerBarton CRM: Pseudo-tuberculous condition associated with eosinophilia, Indian M. Gaz. 75: 607, 1940. MedlineGoogle Scholar10. ApleyGrant JGH: Tropical eosinophilia as seen in England, Lancet 1: 812, 1945. CrossrefGoogle Scholar11. SmithAlexander DCAJ: Transitory lung infiltrations associated with eosinophilia (Löffler's syndrome), South. M. J. 32: 267, 1939. CrossrefGoogle Scholar12. Sheeran HD: Pulmonary infiltration with blood eosinophilia, Am. J. Med. 10: 269, 1951. CrossrefMedlineGoogle Scholar13. HoffmanHuard ILGS: Report of case of Löffler's syndrome with a concomitant non-specific maculo-papular rash, Mil. Surgeon 105: 7, 1949. MedlineGoogle Scholar14. Goodrich BE: Medical Staff Meeting of Henry Ford Hospital, Detroit, Michigan, Dec. 15, 1950. Google Scholar15. ReederMackey WHGS: Nebulized cortisone in bacterial pneumonia, Dis. of Chest 6: 528, 1950. CrossrefGoogle Scholar16. Müller RW: Zur Pathogenese der flüchtigen eosinophilen Lungeninfiltrate, Deutsche med. Wchnschr. 64: 1286, 1938. Google Scholar17. Koino S: Experimental injections on human body with ascarides, Japan M. World 2: 317, 1922. Google Scholar18. Cardis F: A propos de l'infiltrat pulmonaire fugace avec eosinophilie et de son etiologie le plus souvent vermincuse, Schweiz. med. Wchnschr. 75: 165, 1945. Google Scholar19. Stefano J: Sindrome asmatico por amebiasis pulmonar, Semana méd. 2: 749, 1939. Google Scholar20. HoffHicks AHM: Transient pulmonary infiltrations; case with eosinophilia (Loeffler's syndrome) associated with amoebiasis, Am. Rev. Tuberc. 45: 194, 1942. Google Scholar21. Miller H: Transitory lung infiltration accompanied by eosinophilia; report of case, New England J. Med. 232: 7, 1945. CrossrefGoogle Scholar22. WrightGold DOEM: Loeffler's syndrome associated with creeping eruption (cutaneous helminthiasis), J. A. M. A. 128: 1082, 1945. CrossrefGoogle Scholar23. ElsomIngelfinger KAFJ: Eosinophilia and pneumonitis in chronic brucellosis; report of two cases, Ann. Int. Med. 16: 995, 1942. LinkGoogle Scholar24. DavisSmithSmith BLRTCE: Epidemic of coccidioidal infection (coccidioidomycosis), J. A. M. A. 118: 1182, 1942. CrossrefGoogle Scholar25. Dickson EC: Primary coccidioidomycosis, Am. Rev. Tuberc. 38: 722, 1938. Google Scholar26. WillettOppenheim FME: Pulmonary infiltrations with associated eosinophilia, Am. J. M. Sc. 212: 608, 1946. CrossrefMedlineGoogle Scholar27. Gramazio V: Contributo allo studio dei cosidetti "infiltrate polmonari fugaci," Ann. Ist. Carlo Forlanini 6: 237, 1942. Google Scholar28. Emerson K: Tropical eosinophilia, U. S. Nav. M. Bull. 42: 118, 1944. Google Scholar29. LavierBarietyCaroliBoulanger GMJP: Distomatose hepatique et syndrome de Loeffler, Paris méd. 1: 434, 1939. Google Scholar30. van der SarHartz APH: Syndrome, tropical eosinophilia and microfilaria, Am. J. Trop. Med. 25: 83, 1945. CrossrefGoogle Scholar31. CarterWeddD'Abrera HFGVS: Occurrence of mites (acarina) in human sputum and their possible significance, Indian M. Gaz. 79: 163, 1944. MedlineGoogle Scholar32. Estrada de la Riva G: Contribution to the study of tropical eosinophilia, South. M. J. 42: 429, 1949. CrossrefMedlineGoogle Scholar33. MillerPinessFeingoldFriedman HGBFTB: Allergic bronchopneumonia, J. Pediat. 7: 768, 1935. CrossrefGoogle Scholar34. FalkNewcomber MSVD: Loeffler's syndrome: occurrence in two patients treated with penicillin oil and wax, J. A. M. A. 141: 21, 1949. CrossrefMedlineGoogle Scholar35. Alpher IM: Loeffler's syndrome; report of two cases, one with recurrent features, and one associated with hay fever, J. Allergy 18: 39, 1947. CrossrefMedlineGoogle Scholar36. Nagel O: Ein Beitrag zur Pathologie der flüchtigen Lungeninfiltrate mit Bluteosinophilie, Beitr. z. Klin. Tuberk. 96: 185, 1941. CrossrefGoogle Scholar37. Harkavy J: Vascular allergy, J. Allergy 14: 507, 1943. CrossrefGoogle Scholar38. Breton A: A propos de la radiologie de l'asthme; le syndrome de Löffler, Paris méd. 1: 538, 1938. Google Scholar39. Tocker AM: Transitory pulmonary infiltrations (Loeffler's syndrome) with case report, J. Allergy 20: 211, 1949. CrossrefMedlineGoogle Scholar40. Harkavy J: Vascular allergy; pathogenesis of bronchial asthma with recurrent pulmonary infiltrations and eosinophilic polyserositis, Arch. Int. Med. 67: 709, 1941. CrossrefGoogle Scholar41. Maier C: Temporary eosinophilic pulmonary infiltration: summary of more than one hundred observations, Helvet. med. acta 10: 3, 1943. Google Scholar42. Maier C: Ibid. Google Scholar43. Saupe E: Über Lungenrontgenbefunde insbesondere Infiltrate, bei Asthma, Fortschr. a. d. Geb. d. Röntgenstrahlen 61: 65, 1940. Google Scholar44. FreundSamuelson RS: Transitory infiltrations of the lung with eosinophilia; Löffler's syndrome, Arch. Int. Med. 66: 1215, 1940. CrossrefGoogle Scholar45. Smith JH: Loeffler's syndrome, South. M. J. 36: 269, 1943. CrossrefGoogle Scholar46. Baer A: Report of a case of transient pulmonary edema (Loeffler's syndrome), Ohio State M. J. 37: 960, 1941. Google Scholar47. BaggenstossBayleyLindberg AHECDO: Loeffler's syndrome; report of a case with pathologic examination of lungs, Proc. Staff Meet., Mayo Clin. 21: 457, 1946. MedlineGoogle Scholar48. HendersonPeirce ATCB: Transitory focal pulmonary edema and eosinophilia (Löffler's syndrome), Am. J. Roentgenol. 58: 391, 1947. Google Scholar49. EichwaldSingletary MWV: Transient successive pulmonary infiltrations (Loeffler's syndrome), Radiology 46: 258, 1946. CrossrefMedlineGoogle Scholar50. Leon-KindbergAdidaRosenthal MPL: Pneumopathie a eosinophiles, Presse méd. 48: 277, 1940. Google Scholar51. Tomenius J: Löffler's syndrome—periarteritis nodosa, Acta med. Scandinav. 133: 55, 1949. CrossrefMedlineGoogle Scholar52. FreundSamuelson RS: Transitory infiltration of lung with eosinophilia; Loeffler's syndrome, Arch. Int. Med. 66: 1215, 1940. CrossrefGoogle Scholar53. VaughanHawke WTEK: Angioneurotic edema with some unusual manifestations, J. Allergy 2: 125, 1931. CrossrefGoogle Scholar54. Feer W: Quincke'sches Oedem, primar in der Lunge, Schweiz. med. Wchnschr. 61: 186, 1931. Google Scholar55. Danziger J: Personal communication to the author. Cited by Harkavy, J.: Vascular allergy—pathogenesis of bronchial asthma with recurrent pulmonary infiltrations and eosinophilic polyserositis, Arch. Int. Med. 67: 709, 1941. CrossrefGoogle Scholar56. Lewis T: Blood vessels of human skin and their responses, 1927, Shaw and Sons, Ltd., London. Cited by Harkavy, J.: Vascular allergy—pathogenesis of bronchial asthma with recurrent pulmonary infiltrations and eosinophilic polyserositis, Arch. Int. Med. 67: 709, 1941. Google Scholar57. Dale HH: Chemical factors in control of circulation, Brit. M. J. 1: 1093, 1929; Lancet 1: 1179, 1223 and 1285, 1929. CrossrefMedlineGoogle Scholar58. Bohrod MG: Classification of histologic reactions in allergic diseases, Am. J. Med. 3: 511, 1947. CrossrefMedlineGoogle Scholar59. HerbutKinsey PAFR: Transitory pulmonary infiltrations (Loeffler's syndrome) in rabbits, Arch. Path. 41: 489, 1946. Google Scholar60. RichGregory ARJE: Experimental demonstration that periarteritis nodosa is manifestation of hypersensitivity, Bull. Johns Hopkins Hosp. 72: 65, 1943. Google Scholar61. Rich AR: Role of hypersensitivity in periarteritis nodosa as indicated by 7 cases developing during serum sickness and sulfonamide therapy, Bull. Johns Hopkins Hosp. 71: 123, 1942. Google Scholar62. Rich AR: Additional evidence of the role of hypersensitivity in the etiology of periarteritis nodosa, Bull. Johns Hopkins Hosp. 71: 375, 1942. Google Scholar63. GriffithVural GCIL: Polyarteritis nodosa. A correlation of clinical and postmortem findings in seventeen cases, Circulation 3: 481, 1951. CrossrefMedlineGoogle Scholar64. RoseLittmannHoughton MHDJ: Polyarteritis nodosa: a clinical and pathological study and report of six cases, Ann. Int. Med. 32: 1114, 1950. LinkGoogle Scholar65. HarrisLynchO'Hare AWGWJP: Periarteritis nodosa, Arch. Int. Med. 63: 1163, 1939. CrossrefGoogle Scholar66. Hermann W: Pulmonary changes in a case of periarteritis nodosa, Am. J. Roentgenol. 29: 607, 1933. Google Scholar67. SweenyBaggenstoss AFAH: Pulmonary lesions of periarteritis nodosa, Proc. Staff Meet., Mayo Clin. 24: 35, 1949. MedlineGoogle Scholar68. RackemannGreene FMJE: Periarteritis nodosa and asthma, Tr. A. Am. Physicians 54: 112, 1939. Google Scholar69. WilsonAlexander KSHL: Relation of periarteritis nodosa to bronchial asthma and other forms of human hypersensitiveness, J. Lab. and Clin. Med. 30: 195, 1945. Google Scholar70. Bergstrand H: Morphological equivalents in polyarthritis rheumatica, periarteritis nodosa, transient eosinophilic infiltration of lung and other allergic syndromes, J. Path. and Bact. 58: 399, 1946. CrossrefMedlineGoogle Scholar71. von Meyenburg H: Eosinophilic pulmonary infiltration, J. A. M. A. 121: 626, 1943. (Abstr.) Google Scholar72. Brock OJ: Case of transient pulmonary infiltration with eosinophilia, with fatal issue after treatment by adrenalin spray for asthma, Acta med. Scandinav. 113: 311, 1943. CrossrefGoogle Scholar73. Parsons-Smith BG: Tropical eosinophilia, Lancet 1: 433, 1944. CrossrefGoogle Scholar74. Irwin JW: Tropical eosinophilia, Ann. Int. Med. 25: 329, 1946. LinkGoogle Scholar75. HirstMcCann WRWJ: Tropical eosinophilia; report of case, U. S. Nav. M. Bull. 44: 1277, 1945. Google Scholar76. GoodmanGilman LSA: The pharmacological basis of therapeutics, 1941, The Macmillan Company, New York, pp. 972-973. Google Scholar77. ThornBaylesMassellForshamHillSmithWarren GWTBBFPHSRSJE: Studies on relation of pituitary adrenal function to rheumatic disease, New England J. Med. 241: 529, 1949. CrossrefMedlineGoogle Scholar78. DoughertyWhite TFA: Influence of hormones on lymphoid tissue structure and function. Role of pituitary adrenocorticotrophic hormone in regulation of lymphocytes and other cellular elements of blood, Endocrinology 35: 1, 1944. CrossrefGoogle Scholar79. HillsForshamFinch AGPHCA: Changes in circulating leukocytes induced by administration of pituitary adrenocorticotrophic hormone (ACTH) in man, Blood 3: 755, 1948. CrossrefMedlineGoogle Scholar80. Rose B: Studies on the effect of ACTH on eosinophilia and bronchial asthma, Proceedings First Clinical ACTH Conference, 1949, Blakiston Co., Philadelphia, p. 491. Google Scholar81. HerbertRose PB: Observations on the effect of adrenocorticotrophic hormone on a case of Loeffler's syndrome, and a case of tropical eosinophilia, J. Allergy 20: 79, 1949. (Abstr.) Google Scholar82. GoldmanAdamsBeckLevinBassett RWSWSMSH: The effect of ACTH on one case of periarteritis nodosa, Proceedings First Clinical ACTH Conference, 1949, Blakiston Co., Philadelphia, p. 437. Google Scholar83. ShickBaggenstossFullerPolley RMAHBFHF: Effect of cortisone and ACTH on periarteritis nodosa and cranial arteritis, Proc. Staff Meet., Mayo Clin. 25: 492, 1950. MedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Detroit, Michigan*Received for publication July 23, 1951.From the Cardiorespiratory Division of the Department of Medicine, Henry Ford Hospital, Detroit, Michigan. 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PERRAULT, M.D., MICHEL JANIS, M.D., HARVEY WOLINSKY, M.D., Ph.D.Eosinophilic Infiltrations of the Lungs in AsthmaticsArterial Calcification Associated with Hypereosinophilic SyndromeSTUART N. NOVACK, M.D., THOMAS L. KUN, M.D., LEONARD S. GOLDBERG, M.D.Restrictive lung disease: The view from pathologyChronic Eosinophilic PneumoniaPulmonary Infiltrations with Eosinophilia as a Manifestation of CarcinomaThe Allergist and the EosinophilThe Hypereosinophilic SyndromesWILLIAM R. HARDY, M.D., ROBERT E. ANDERSON, M.D.Pulmonary infiltrates, pericarditis and eosinophiliaParasitic aetiology of tropical eosinophiliaPULMONARY INFILTRATION WITH EOSINOPHILIA (LÖFFLER'S SYNDROME) DUE TO SMOKE INHALATION: REPORT OF A CASE AND COMMENT ON PATHOGENESIS*WILLIAM TSCHUMY JR., M.D.INFILTRATIVE EOSINOPHILIA*†R. S. DÍAZ-RIVERA, M.D., F.A.C.P., F. RAMOS-MORALES, M.D., M. R. GARCÍA-PALMIERI, M.D., Z. R. SOTOMAYOR, M.D., A. A. CINTRÓN-RIVERA, M.D.TROPICAL EOSINOPHILIA: CLINICAL, THERAPEUTIC AND ETIOLOGIC CONSIDERATIONS. EXPERIMENTAL WORK*AMAURY COUTINHODie eosinophilen LungeninfiltrateThe use of corticotrophin and corticosteroids in pulmonary diseasePulmonary roentgenologic changes in the collagen diseasesTropical EosinophiliaProlonged pulmonary eosinophiliaOcular Manifestations in Loffler's SyndromeSTRUCTURE OF GROUND SUBSTANCEP.I.E. OR P.U.O. ? 1 May 1952Volume 36, Issue 5Page: 1217-1240KeywordsAllergic diseasesDiagnostic radiologyEosinophiliaHospital medicinePulmonary diseasesThorax Issue Published: 1 May 1952 PDF downloadLoading ...