tbuckley/cabot-search huggingface dataset:
Abstract 16858: Factors Associated With Length of Stay and Cost of the Fontan Surgery: A Multi-Institutional Study
Authors: Shaji C Menon, Kevin Hinkle, Molly McFadden, Jacob Wilkes, L. LuAnn Minich
Journal: Circulation (2014)

Introduction: We sought to determine factors associated with length of stay (LOS) and cost of the Fontan surgery in a contemporary large multi-institutional cohort. Hypothesis: Independent and modifiable risk factors associated with longer LOS and higher cost will be identified. Methods: We performed a retrospective cohort study of Fontan surgey (1/2004 - 7/2013) using the Pediatric Health Information Systems (PHIS) database (40 US children’s hospitals). Outcome parameters were LOS and costs at Fontan surgery. Predictor variables were demographics (race, insurance, region, rural vs city, commute time, surgical volume), cardiac and other diagnoses, Glenn events, readmission between Glenn and Fontan, and age at Glenn and Fontan. Following a stepwise selection procedure, significant predictors of LOS and cost were included in a generalized linear model with the appropriate inverse Gaussian distribution and the log link function with LOS and cost (adjusted to 2012 $ and region) as the dependent variable. Results: For the 2187 patients (62% male) who had Fontan surgery, the median age at surgery was 1146 days (IQR: 943-1369) and at Glenn was 165 days (IQR: 133-208). Following Fontan, the median ICU LOS was 3 days (IQR: 2-6) and total LOS was 9 days (IQR: 7-14). The median total hospital cost was $93, 900 (IQR: 67,800-136,100). Post-operative mortality was 1% (N=21). Region, insurance, race, surgical volume were the predominant factors associated with both cost and LOS (Table 1). Conclusion: This is the largest multicenter contemporary study describing the factors (particularly healthcare delivery factors) associated with resource utilization during the Fontan hospitalization. Health care delivery variables dominated the factors predicting increased resource utilization. Changes in health care policy should target health care delivery risk factors (race, region, insurance, driving distance, surgical volume) to reduce cost in this resource intensive population.
Abstract 12856: High Prevalence of Healed Ruptured Plaques Detected by Optical Coherence Tomography in Coronary High-Intensity Plaques on Non-Contrast T1-Weighted Magnetic Resonance Imaging
Authors: Tomoaki Kanaya, Teruo Noguchi, Hideyasu Asaumi, Reiko Fujiwara, Masashi Fujino, Takafumi Yamane, Toshiyuki Nagai, Shouji Kawakami, Satoshi Honda, Masaharu Ishihara, Youichi Gotoh, Hisao Ogawa, Satoshi Yasuda
Journal: Circulation (2014)

Background:  We have shown that coronary high-intensity plaques (HIPs) on non-contrast T1-weighted imaging (T1WI) represent plaque vulnerability. However, it remains unclear whether HIPs are associated with vulnerable plaque features detected by optical coherence tomography (OCT) such as thin-cap fibroatheroma (TCFA), plaque rupture, or intra-coronary thrombus. Recently, healed ruptured plaques, comprised of a layered pattern underlying poor signaled region with diffuse border, is a novel feature for predicting plaque vulnerability.   Method:  Twenty-one patients with stable coronary artery disease (CAD) underwent non-contrast T1WI within 2 days prior to elective percutaneous coronary intervention (PCI) with OCT study to calculate the plaque-to-myocardium signal intensity ratio (PMR). CAD patients were categorized as HIP positive if any lesion identified plaque had a PMR>1.4.   Results:  Of the 22 lesions studied, 11 (50%) lesions were positive for HIP and 11 (50%) were negative for HIP (non-HIP). Figure shows a representative case having left anterior descending artery lesion (A, arrow) that was positive for HIP with 2.27 of PMR (B) and was characterized as healed ruptured plaque by OCT (C). There were no significant differences in age, male gender, and history of diabetes mellitus, hypertension, dyslipidemia, and current smoking. On OCT analysis, in the HIP group, the prevalence of healed rupture plaque was significantly higher (HIP, 82% vs. non-HIP, 27%, p=0.03) and the degree of lipid-arc was greater than non-HIP group (HIP, 201.0 ± 26.7° vs non-HIP, 171.5 ± 35.3°, p=0.034). However, no significant differences were observed in the prevalence of TCFA, lipid-rich plaque, ruptured plaque, thrombus, and calcification between the 2 groups (Table).   Conclusions:  The present OCT analysis showed that prevalence of healed ruptured plaque and degree of lipid-arc were high in plaques with HIPs, which are therefore associated with plaque vulnerability.
Preventative Ophthalmology
Authors: Neil M. Bressler, Susan B. Bressler
Journal: Ophthalmology (1995)

This report was designed to review the current knowledge about preventing the development or progression of age-related macular degeneration (AMD) and visual loss associated with this entity in practical terms for the comprehensive ophthalmologist.Animal studies, epidemiologic studies, and clinical trials identified through the use of MEDLINE, a reference list of articles reviewed, and personal contact with experts in this area provided information reviewed for this report.Reports concerning ultraviolet and visible light provide limited, inconsistent, and conflicting data to support the theory that light exposure leads to AMD. Micronutrient supplementation is a provocative but largely unproven hypothesis. Positive associations of cigarette smoking and cardiovascular disease or certain risk factors for cardiovascular disease with AMD provide potential clues as to the underlying pathogenesis of AMD and are yet another reason to treat these health problems. Drusen may disappear after laser to the macula; however, this intervention will require careful, randomized, prospective trials to determine if this therapy can reduce the risk of choroidal neovascularization and visual loss developing in patients with AMD.It is reasonable to have individuals wear sunglasses for comfort and possible protection from ultraviolet light exposure to all ocular structures (especially the lens) at little or no risk to the patient. Physicians probably should be reluctant to prescribe micronutrients or suggest other interventions (such as laser to drusen) until their health claims have been substantiated and their long-term safety soundly established.
Occupational allergy in apprentices hairdressers and hairdressers in region of Lodz, Poland
Authors: Patrycja Krawczyk-Szulc, Beata Krecisz, Dorota Chomiczewska, Marta Wiszniewska, Marta Kiec-Swierczynska, Ewa Nowakowska-Swirta, Joanna Zgorzelska-Kowalik, Cezary Palczynski, Aleksandra Golinska-Zach, Jolanta Walusiak-Skorupa
Journal: European Respiratory Journal (2011)

Hairdressers are exposed to various chemical factors and agents that cause occupational respiratory and skin diseases.   Aim:  The aim of the study was to assess the prevalence and risk factors of occupational allergy in apprentices hairdressers and hairdressers from the region of Lodz in Poland.   Material and methods:  Prospective study was done in apprentices. A group of apprentices hairdressers were tested twice (34 at the beginning of education and 21 at the end) for respiratory and skin allergy. 54 hairdressers were tested for respiratory and 40 for skin allergy.   Results:  The prevalence of respiratory symptoms in apprentices after two years at school was not significantly higher after 2 years of education. One student became sensitized to latex. Positive skin prick tests to common allergens was a risk factor of rhinitis related to work in apprentices hairdressers OR = 9,75 (CI 1,03 – 14,64).  Prevalence of cough, dyspnoe and rhinitis was significantly higher in hairdressers than apprentices in the 1st class (p  Two of 54 hairdressers was sensitized to ammonium persulfate and one to paraphenylenediamine. One subject had an occupational astma diagnosis.  Contact allergy was common in hairdressers and apprentices, however more prevalent in the first group.   Conclusions:   Respiratory symptoms were not the most important health problem in apprentices hairdressers at the end of education probably due to “healthy worker effect”.  Hypersensitivity to common allergens in apprentices and smoking in hairdressers were risk factors of respiratory symptoms.
577. MVA-MUC1-IL2 Vaccine Immunotherapy for Patients Post-Prostatectomy with Rising PSA and No Evident Metastases
Authors: Robert Dreicer, Frederick Ahman, Allan Pantuck, Caroline Beunkens, Nadine Bizouarne, Bruce Acres, Teresa Maciejewska, Patrick Squiban
Journal: Molecular Therapy (2004)

Background: Over-expression, non-polarity and under-glycosylation of the mucin glycoprotein molecule, MUC1, are associated with many cancers, making MUC1 an attractive target antigen for vaccine immunotherapy of cancer. MVA (Modified Vaccinia Ankara), a highly attenuated Vaccinia virus, is non-propagative in most mammalian cells and has an excellent safety profile. We have produced a recombinant MVA expressing MUC1 and IL2 (TG4010). Murine studies have shown that TG4010 can induce a MUC1 specific immune response associated with the elimination of MUC1 expressing tumors.
Quality of Life
Authors: M. R. Lucas, T. S. Armstrong, A. Acquaye, D. Balachandran, A. Mahajan, D.-H. Kang, E. Vera-Bolanos, M. R. Gilbert, M. P. Lovely, M. Page, K. Mogensen, J. Arzbaecher, C. Amidei, K. Lupica, M. E. Maher, P. Sherwood, S. Kagan, E. M. Sizoo, H. R. W. Pasman, J. C. Reijneveld, J. J. Heimans, L. Deliens, M. J. Taphoorn, R. Sheth, B. T. Bagan, M. N. Baig, C. Karas, D. I. Jacobs, S. A. Grimm, A. Rademaker, L. Rice, J. P. Chandler, K. Muro, M. Marymount, I. B. Helenowski, L. I. Wagner, C. L. Bennett, J. J. Raizer, A. Evans, G. Dhall, J. Finlay, K. Wong, G. McComb, R. Soffietti, R. P. Mueller, U. Abacioglu, S. Villa, F. Fauchon, B. Baumert, L. Fariselli, G. Tridello, M. Kocher, A. Bottomley, C. Pendleton, H. Adams, G. I. Jallo, B. S. Carson, E. Ahn, A. Quinones-Hinojosa, A. A. Acquaye, E. Vera-Bolanos, T. S. Armstrong, B. N. Bekele, M. R. Gilbert, D. I. Jacobs, S. A. Grimm, A. Rademaker, L. Rice, J. Chandler, K. Muro, M. Marymount, I. B. Helenowski, L. I. Wagner, J. J. Raizer, V. Nestor, K. Fink, M. Nashed, M. Linskey, D. A. Bota, W. Hoeben, K. Hilverda, J. J. Heimans, M. J. Taphoorn, T. J. Postma, J. Buter, J. Lenting, E. H. Collette, J. C. Reijneveld, M. Klein, D. van Nieuwenhuizen, L. Bosscher, E. Szymanska, J. J. Heimans, S. M. Peerdeman, M. Klein, J. C. Reijneveld, D. van Nieuwenhuizen, T. Erdmann, J. J. Heimans, J. C. Reijneveld, S. M. Peerdeman, M. Klein, S. N. Lawrence Recht, T. Armstrong, E. Vera-Bolanos, I. Gning, A. Acquaye, M. R. Gilbert, C. Cleeland, T. R. Mendoza, N. Jouniaux-Delbez, J. Y. Delattre, S. T. du Montcel, N. Butowski, R. Parvataneni, A. Nicole, K. Lamborn, M. Polley, J. Clarke, S. Chang, M. Page, M. Prados, A. Liepa, P. Shi, D. Thornton, C. A. Kahlenberg, C. E. Fadul, R. Scott, D. W. Roberts, V. Thadani, K. Bujarski, E. C. Lallana, B. C. Jobst, J. G. Walker, D. Schultz, K. Grisdale, M. D. Groves, K. B. Peters, D. A. Reardon, J. J. Vredenburgh, A. Desjardins, H. S. Friedman, D. H. Allen, B. Carlson, V. Neelon, K. Giovanello, J. Carlson, R. Raynor, A. Desjardins, L. Rice, R. Lall, S. Ha, M. Marymont, S. Grimm, J. Raizer, J. Chandler, K. Muro, S. T. Keir
Journal: Neuro-Oncology (2010)
Abstract 1902: Comparison of 256×0.5mm and 64×0.5mm Multidetector Computed Tomography Image Quality and Accuracy in a Custom-Designed, Motion-Simulating Phantom of Coronary Artery Stenosis
Authors: Kakuya Kitagawa, Armin Arbab-Zadeh, Katherine M Hannon, Richard T George, Joao A Lima, Albert C Lardo
Journal: Circulation (2007)

BACKGROUND: 256 multidetector computed tomography (256-MDCT) can image the entire heart volume in a single gantry rotation without table movement and therefore may eliminate helical imaging reconstruction artifacts. However, image quality and quantitative accuracy of coronary artery measurements by 256-MDCT relative to 64-MDCT has not been previously evaluated. The purpose of this study was to compare the accuracy and image quality of 256×0.5mm-MDCT versus 64×0.5mm-MDCT using a custom-designed, motion-simulating coronary artery phantom. METHODS: Coronary artery phantoms with various reference diameter (1.5, 2, 3 and 4mm) and stenoses of various magnitude (0.8–3.1mm) and shape (half moon, concentric, eccentric, 0.13–10.2 mm2 in area) were scanned during simulated cardiac motion at 60 bpm using 256-MDCT (ECG-gated non-helical) and 64-MDCT (ECG-gated helical). Vessel diameter and cross-sectional area were measured in a total of 24 stenoses by two observers using multiplanar reformation of MDCT data. RESULTS:...
Biotechnology Products and University-Based Science
Authors: David Korn, Stephen J Heinig
Journal: JAMA (2005)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Internet Seen as Clinical Research Tool
Authors: Mike Mitka
Journal: JAMA (2005)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Abstract 19542: Endocardial EphB4 Signaling Regulates Neuregulin-1 Expression and is Critically Required for Myocardial Development
Authors: Jiang Liu, Binyun Ma, Hai-Yun Yen, Parkash S Gill, Henry M Sucov, S. Ram Kumar
Journal: Circulation (2014)

The vertebrate ventricular myocardium is formed by a complex and incompletely understood developmental paradigm that regulates accurate organization of an inner trabecular and outer compact zone layers. EphB4, a member of the largest family of receptor tyrosine kinases, is expressed in the developing endocardium, along with its cognate ligand EphrinB2. Whereas EphB4 and EphrinB2 have well-established roles in vascular maturation, their role in cardiac development is unknown. In this study, we show that disruption of embryonic EphB4 expression in the second heart field (Mef2c-cre) or endocardium (Nfat-1c cre) results in a severely thinned and underdeveloped myocardial layer, ventricular non-compaction, heart failure and embryonic lethality around E15.5. Mutant hearts show reduced activation of PI3K pathway and impaired proliferation of developing cardiomyocytes. Knockdown of EphB4 alters multiple downstream signaling pathways of significance in cardiac development. In particular, EphB4 expression regulates neuregulin-1 levels both in vitro and in vivo, which then activates myocardial ErbB receptor signaling. Our study re-iterates the critical role of endocardial signaling in myocardial development. In addition, we identify EphB4 as a novel upstream modulator of Neuregulin-1, and thereby, a critical regulator of myocardial development - a hitherto unrecognized function of this receptor tyrosine kinase.
Bone Densitometry Testing in Nonwhite Patients
Authors: John N. Hathcock
Journal: JAMA (2003)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Synergistic interactions of disulfiram, BSO and arsenic trioxide on drug resistant melanoma cell lines.
Authors: John P. Fruehauf, Frank Meyskens
Journal: Cancer Research (2006)

Proc Amer Assoc Cancer Res, Volume 47, 2006

5409 

Purpose : To investigate the cytotoxic effects of arsenic trioxide (ATO) in combination with disulfiram (DSF) and buthionine sulfoximine (BSO) on metastatic melanoma cells. Method s: Cell growth was measured using the XTT assay. Dose-response of multiple drugs was analyzed using Chou’s method for synergy analysis. Tietze’s enzymatic recycling method was used to determine cellular glutathione levels in drug-treated A375, M14, and c81-61 metastatic melanoma cells. Results : All three cell lines exhibited dose-dependent response to ATO, DSF, and BSO. The c81-61 cells were the least sensitive to the three agents tested. For A375 cells, the greatest synergy was observed for the combinations of 1.25uM ATO/0.25uM DSF, 1.25uM ATO/65.6uM BSO. For c81-61 cells, synergy was observed at 0.625uM ATO/0.125uM DSF and 0.3125uM ATO/15.625uM BSO. An enhanced anti-melanoma effect was observed for prolonged 6-day exposures. Total glutathione levels in ATO-treated A375 cells decreased from 48 hours to 72 hours. Conclusion s: The synergistic cytotoxicity of ATO combination with DSF or BSO on A375, M14, and c81-61 cells may be associated with changes in intracellular glutathione (GSH) levels.
Abstract 15966: Macrophage P90rsk Accelerates Atherosclerosis by Inhibiting Efferocytosis
Authors: Kyungsun Heo, Massashi Akaike, Jack Taunton, Keigi Fujiwara, Jun-ichi Abe
Journal: Circulation (2014)

Backgrounds:  We have previously reported that ERK5 activation promotes efferocytosis and downregulates atherosclerosis (AS). The impairment of efferocytosis in advanced plaque has been suggested, but the regulatory mechanisms are largely unknown.   Methods and Results:  Immunohistochemistry studies on LDLR-/- mice showed that p90RSK activation was significantly up-regulated in advanced plaques, especially in MΦ. We have reported that p90RSK activation inhibits ERK5 transcriptional activity and intensifies endothelial inflammation via phosphorylation of ERK5 S496. In this study, we investigated the role of MΦ p90RSK in regulating ERK5 and efferocytosis. Angiotensin II (AngII) is known to impair efferocytosis and we found that 200 nM AngII activated p90RSK. AngII treatment and adenovirus (Ad)-wild type (WT) p90RSK overexpression inhibited ERK5 transcriptional activity and subsequent expression of the efferocytosis- and M2-type-related genes. These inhibitions were completely reversed by a highly selective p90RSK inhibitor, FMK-MEA. To determine the unique role of MΦ p90RSK in AS, we generated floxed WT- and dominant negative (DN, K94A/K447A)-p90RSK mice and crossed them with LysMCre/LDLR-/- mice (WT (or DN)-p90RSK-MTg /LDLR-/-). A significant increase in ERK5 S496 phosphorylation and down-regulation of efferocytosis-related gene expression were observed in the peritoneal MΦ from WT-p90RSK-MTg mice. We also injected fluorescently labeled apoptotic cells (AC) in the peritoneum of the mice to study AC clearance in vivo. Delayed clearance by resident peritoneal MΦ was observed in WT- but not in DN-p90RSK-MTg, suggesting a key role of p90RSK activation in regulating efferocytosis. To evaluate the role of MΦ p90RSK on AS, WT or DN-p90RSKMTg/LDLR-/- mice were fed a high cholesterol diet for 16-week. We found that AS and necrotic core formations were significantly accelerated in WT- but not DN-p90RSK-MTg/LDLR-/- animals. Taken together, these data suggest that MΦ p90RSK activation promotes AS via inhibiting ERK5-mediated efferocytosis and M2-type gene induction.   Conclusion:  The lack of balance between p90RSK and ERK5 activities in advanced plaques is a key event for determining efferocytosis and subsequent vulnerable plaque development.