References on Sodium-Retaining Potency of Corticosteroids
Authors: LAWRENCE PARKER
Journal: Annals of Internal Medicine (1979)

Letters and Corrections1 May 1979References on Sodium-Retaining Potency of CorticosteroidsLAWRENCE PARKER, M.D., ALEX KUTAS, M.D., MICHAEL BOLOGNESE, M.D., RONALD SKOWSKY, M.D.LAWRENCE PARKER, M.D.Search for more papers by this author, ALEX KUTAS, M.D.Search for more papers by this author, MICHAEL BOLOGNESE, M.D.Search for more papers by this author, RONALD SKOWSKY, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-90-5-853_2 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: There are two major reasons to measure accurately the mineralocorticoid potency of a corticosteroid preparation. First, a corticosteroid must be used for its anti-inflammatory effect without inducing excessive sodium retention that causes edema and congestive heart failure. Second, the choice of replacement therapy in a patient with primary adrenal insufficiency depends on the ratio of glucocorticoid to mineralocorticoid activity. A corticosteroid preparation with little or no sodium-retaining properties must often be supplemented with a more potent mineralocorticoid to prevent hyperkalemia, hypotension, or vascular collapse.Comparison of the reported mineralocorticoid potencies of some widely used corticosteroids, as listed...References1. GOODMANGILMAN LA: The Pharmacological Basis of Therapeutics, 5th ed. New York, Macmillan Publishing Co., Inc., 1975, p. 1491 Google Scholar2. THORNADAMSBRAUNWALDISSELBACHERPETERSDORF GREKR (eds.): Harrison's Principles of Internal Medicine, 8th ed. New York, McGraw-Hill Book Co., 1977, p. 554 Google Scholar3. WILLIAMS R (ed.): Textbook of Endocrinology, 5th ed. Philadelphia, W. B. Saunders Company, 1974, p. 246 Google Scholar4. BONDYROSENBERG PL (eds.): Duncan's Diseases of Metabolism, 7th ed. Philadelphia, W. B. Saunders Co., 1974, p. 1131 Google Scholar5. ROSENFELD M (ed.): Manual of Medical Therapeutics (Washington University) 22nd ed. Boston, Little, Brown and Co., 1977, p. 351 Google Scholar6. HOLLANDERMCCARTY JD: Arthritis and Allied Conditions: A Textbook of Rheumatology, 8th ed. Philadelphia, Lea and Febiger, 1972, p. 503 Google Scholar7. GARDNER L (ed.): Endocrine and Genetic Diseases of Childhood and Adolescence. Philadelphia, W. B. Saunders Co., 1975, p. 532 Google Scholar8. Medical Letter. New York, The Medical Letter, Inc., 1977, p. 100 Google Scholar9. THORNLAULER GD: Clinical therapeutics of adrenal disorders. Am J Med 53:673-684, 1972 CrossrefMedlineGoogle Scholar10. FAUCIDALEBALOW ADJ: Glucocorticosteroid therapy: mechanisms of action and clinical considerations. Ann Intern Med 84:304-315, 1976 LinkGoogle Scholar11. MOYER C (ed.): Surgery: Principles and Practice. Philadelphia, J. B. Lippincott Co., 1965, p. 725 Google Scholar12. : AMA Drug Evaluations. Littleton, Massachusetts, Publishing Sciences Group, Inc., 1977, p. 526 Google Scholar13. LIDDLE G: Studies of structure-function relationships of steroids. Metabolism 7:405-415, 1958 MedlineGoogle Scholar14. MARCUSROMANOFFPINCUS FLG: The electrolyte-excreting activity of adrenocortical substances. Endocrinology 50:286, 1952 CrossrefMedlineGoogle Scholar15. LIDDLEPECHETBARTTER GMF: Enhancement of biological activities of corticosteroids by substitution of halogen atoms in 9 ∝-position. Science 120:496, 1954 CrossrefMedlineGoogle Scholar16. TOLKSDORF S: Laboratory evaluation of anti-inflammatory steroids. Ann NY Acad Sci 82:829, 1959 CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: LAWRENCE PARKER, M.D.; ALEX KUTAS, M.D.; MICHAEL BOLOGNESE, M.D.; RONALD SKOWSKY, M.D.Affiliations: Veterans Administration Medical Center Long Beach, CA 90822 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 May 1979Volume 90, Issue 5Page: 853-854KeywordsEdemaGlucocorticoid therapyHeart failureHypotensionMineralocorticoidsSodium ePublished: 1 December 2008 Issue Published: 1 May 1979 PDF downloadLoading ...