tbuckley/cabot-search huggingface dataset:
Abstract 9114: Circulating Biomarkers of Collagen Type I Metabolism Mark Right Ventricular Fibrosis and Indications for Pulmonary Valve Replacement in Adults with Repaired Tetralogy of Fallot
Authors: Chun-An Chen, Wen-Yih I Tseng, Jou-Kou Wang, Ssu-Yuan Chen, Hsin-Hui Chiu, Chung-I Chang, Ing-Sh Chiu, Yih-Sharng Chen, Chun-Wei Lu, Ming-Tai Lin, Mei-Hwan Wu
Journal: Circulation (2011)

Background: Right ventricular (RV) fibrosis is common in patients with repaired tetralogy of Fallot (rTOF). Previous works have shown that cardiac fibrosis could be monitored from circulating biomarkers of collagen metabolism. We assessed the hypothesis that the expression of circulating biomarkers of collagen type I metabolism is altered in rTOF, and could mark in vivo cardiac fibrosis and adverse outcomes. Methods: Serum biomarkers of collagen type I synthesis (carboxy-terminal propeptide of procollagen type I, PICP), degradation (carboxy-terminal telopeptide of collagen type I, CITP), and enzymes regulating collagen turnover (matrix metalloproteinases, MMPs, and type I tissue inhibitor, TIMP-1) were measured in 70 adults with rTOF and 91 age- and sex-matched controls. All patients underwent cardiac magnetic resonance (CMR) to evaluate biventricular function and late gadolinium enhancement (LGE). Patients were classified as with or without indications for pulmonary valve replacement (PVR) based on clinical symptoms, exercise capacity, and CMR-derived measurements. Results: In patients with rTOF, PICP (median 87.7 [25%-75% percentile 68.9-115.6] vs. 58.9 [48.4-71.9] ng/mL, P &lt; 0.001) and PICP:CITP ratio (23.1 [17.5-30.7] vs. 16.5 [13.6-21.7], P &lt; 0.001) were significantly higher than in controls. TIMP-1 was elevated (168.4 [145.7-180.3] vs. 107.3 [91.8-124.2] ng/mL, P &lt; 0.001) without concomitant increase in MMP-1, -2, -3, and -9. Patients with PVR indications had higher PICP ( P = 0.009) and PICP:CITP ratio ( P = 0.078) than those without. In addition, a higher PICP correlated with a higher RV LGE score ( r = 0.427, P &lt; 0.001) and a lower exercise capacity ( r = -0.465, P = 0.001). In multivariate analysis, PICP was associated with the probability of the presence of indications for PVR (odds ratio 1.80 per 10 ng/mL, P = 0.003). Conclusions: Collagen type I overproduction and uncoupled degradation were found in patients with rTOF. Circulating PICP not only correlated with RV LGE, but also linked to adverse markers of clinical outcome indicating the need for PVR. These findings may give us new insight into the pathophysiology of adverse RV remodeling in rTOF, and form the basis for the development of new therapeutic strategies in these patients.
What He Gave Up
Authors: Gary Stein
Journal: JAMA (2001)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
A memorable patient: As in a mirror
Authors: K. Guest
Journal: BMJ (2002)

Recently, I saw a young woman. She had come in to inform me of her progress, as she knows how long hospital letters take to get through. She knows this because she works in the NHS. A month earlier, she had been diagnosed with lupus erythematosus. She has been given some rudimentary information at the clinic and some prednisolone. She has been told that her blood tests and antibody measurements were not in her notes but that they'd been seen and were “OK.”

As you might expect of an intelligent young graduate working in the health service, she had done some research. …
Association between airway hyperresponsiveness, obesity, and lipoproteins in a young Danish cohort
Authors: Finn Rasmussen, Nair Parameswaran, Mads Nybo, Bob Hancox
Journal: European Respiratory Journal (2011)

Rationale:  Epidemiological data have linked obesity with an increased risk of asthma in the community. However, the mechanisms responsible for this relationship remain unknown. The present study investigated the association between airway hyperresponsiveness to methacholine (AHR) and body mass index (BMI) and plasma lipoproteins (LDL, HDL and total cholesterol).   Methods:  Associations between AHR, BMI and plasma lipoproteins were assessed in a population-based cohort at ages 14 and 20 years.   Main results:  In unadjusted analyses, higher LDL cholesterol levels at age 14 were associated with AHR to methacholine at age 20 in both sexes (p   Conclusions:  We confirmed that there is a strong association between BMI and AHR to methacholine in young people. This association seems to be independent of the plasma lipoproteins levels and we did not find an independent association between levels of lipoproteins and AHR.
In ischemic stroke, early intraarterial treatment plus alteplase improved reperfusion and functional outcome
Authors: Gregory Jacquin, Wieslaw Oczkowski
Journal: Annals of Internal Medicine (2015)

Source Citation Campbell BC, Mitchell PJ, Kleinig TJ, et al; EXTEND-IA Investigators. Endovascular therapy for ischemic stroke with perfusion-imaging selection. N Engl J Med. 2015;372:1009-18. 25671797
929. Target Adult Stem Cells to Ischemic Hearts by Regulated Stromal Cell-Derived Factor 1 Gene Transfer
Authors: Yao Liang Tang, Keping Qian, Leping Shen, M. Ian Phillips, Y. Clare Zhang
Journal: Molecular Therapy (2004)

Adult bone marrow-derived stem cells (BMSCs) have emerged as a promising source for regeneration of tissues including those traditionally considered terminally differentiated, for instance, heart and brain. Chronic heart failure afflicts 4.8 million Americans, for those at the end stage of this disease heart transplantation remains the only and last resort. Acute myocardial infarction (AMI) is a leading cause of heart failure. Increasing evidence suggests that the body has a natural response for cardiac repair by up-regulating stromal cell-derived factor 1 (SDF-1), a stem cell active chemokine, which leads to recruitment of circulating BMSCs to ischemic hearts. However, up-regulation of endogenous SDF-1 is transient and inadequate to induce functionally meaningful heart regeneration. Therefore, the current study aimed to enhance stem cell-initiated cardiac repair by targeting circulating BMSCs to ischemic myocardium through targeted and regulated SDF-1 gene expression. To accomplish this goal, we have developed a regulatable system that consists of a MLC-2v promoter for cardiac selective expression as well as an oxygen-sensitive gene switch based on the oxygen-dependent degradation domain of hypoxia inducible factor 1α. It delivers genes of interest in a cardiac-selective and hypoxia-regulated manner in vitro and in vivo. AMI was surgically induced in adult BALB/c mice. DNA plasmid encoding hypoxia-regulated human SDF-1 was administered via intra-myocardial injection. PKH26 labeled BMSCs (6 × 106) were systemically injected immediately after induction of AMI. hSDF-1 expression was evaluated by Western blot analysis and the efficiency of hSDF-1 to attract implanted BMSCs was assessed by immunofluorescent staining and confocal microscopy. 1 week post AMI, hSDF-1 expression was markedly increased in the ischemic mouse heart, while less or no expression was detected in spleen, liver, lung, kidney and skeletal muscle nor in the heart of non-MI group. Confocal microscopy showed that hSDF-1 was highly expressed in the peri-infarct zone, with PKH26-labeled BMSCs enriched nearby. Furthermore, infarct size and cardiac fibrosis were significantly reduced in mice treated with hSDF-1 plus BMSCs compared to BMSCs alone. Taken together, our results indicate that cardiac-selective and hypoxia-inducible SDF-1 gene transfer activated mobilization of BMSCs to ischemic hearts and facilitated post-ischemic repair. This combined approach of regulated gene transfer and adult stem cells may provide a novel, safe and effective strategy for regenerative medicine, leading to efficient and timely repair of injured tissues.
Abstract 12062: Patient and Caregiver Heart Failure Symptom Response Behaviors in 364 Patient-Caregiver Dyads
Authors: Julie T Bidwell, Ercole Vellone, Karen S Lyons, Shirin O Hiatt, Rosaria Alvaro, Barbara Riegel, Christopher S Lee
Journal: Circulation (2014)

Introduction: Recognition and response to symptoms of heart failure (HF) is critical to reducing the risk of hospitalization and mortality. Although many patients have support from caregivers, little is known about caregivers’ contributions to HF symptom response behaviors. We hypothesized that patient-, caregiver-, and dyad-level factors would be associated with better symptom response behaviors. Methods: This was a secondary analysis of data on 364 Italian HF patient-caregiver dyads. HF symptom response behaviors were measured using patient and caregiver versions of the Self-Care of Heart Failure Index (0-100; higher = better). Health status (SF-12) and relationship quality (single item) were collected from patients and caregivers. Patient cognition and comorbidities were measured using the MMSE and Charlson Index. Caregiver social support was measured with the Carers of Older People in Europe Index. Hospitalizations were abstracted from the medical record. Multilevel modeling was used for all analyses. Results: Patients were older (age 76.3±10.8 years), predominantly male (57.3%) and most had NYHA Class II/III HF (72.2%). Caregivers were younger (age 57.7±14.6 years), and most were female (51.7%) and adult child (53.6%) or spousal (34.0%) caregivers. Symptom response behaviors were poor in patients (49.1±19.6) and caregivers (54.7±18.3). Patient gender (male β=-4.60±1.92, p&lt;0.05), better cognition (β=0.40±0.19, p&lt;0.05), worse caregiver health (β=-0.43±0.14, p&lt;0.01), and higher relationship quality (β=2.28±0.83, p&lt;0.01) were significant determinants of better patient symptom response. Nonspousal relationship (β=6.62±1.96, p&lt;0.001), fewer patient comorbidities (β=-2.32±0.79, p&lt;0.01), better patient health (β=0.41±0.12, p=0.001), more hospitalizations (β=3.06±1.41, p&lt;0.05), higher relationship quality (β=2.12±0.84, p&lt;0.01), and higher caregiver social support (β=1.09±0.43, p&lt;0.05) were significant determinants of better caregiver symptom response. Conclusions: Combinations of individual and relationship factors were significant determinants of patient and caregiver responses to HF symptoms. Assessment of patient and caregiver as a dyad may be useful in evaluating risk for poor management of HF symptoms.
Clinoenstatite coatings have high bonding strength, bioactive ion release, and osteoimmunomodulatory effects that enhance in vivo osseointegration
Authors: Chengtie Wu, Zetao Chen, Qianju Wu, Deliang Yi, Thor Friis, Xuebin Zheng, Jiang Chang, Xinquan Jiang, Yin Xiao
Journal: Biomaterials (2015)
Abstract 3775: Identification of PHF6 as a temozolomide resistance factor in glioblastoma using mirConnX
Authors: Lotte Hiddingh, Rajiv S. Raktoe, Gertjan J.L. Kaspers, W. Peter Vandertop, David P. Noske, Pieter Wesseling, Thomas Wurdinger
Journal: Cancer Research (2014)

Abstract Background: Intrinsic and acquired resistance to temozolomide (TMZ) represents a major obstacle in the treatment of glioblastoma. MicroRNAs (miRNAs) have previously been implicated to play a role in chemoresistance including TMZ resistance. These short non-coding RNA sequences inhibit their mRNA targets, thereby contributing to treatment resistance. In this study, we examined the miRNA/mRNA interaction networks in TMZ resistant glioblastoma cell lines to identify drug targets for the reversal of TMZ resistance. Methods: TMZ resistance was induced in duplicate in the glioblastoma cell lines U87, Hs683, and LNZ308, creating two independent resistant subclones of each wildtype cell line. IC50 values were increased at least two-fold in the TMZ resistant subclones compared to their wildtype. mRNA and miRNA expression profiles of these cell lines were obtained by microarray data analysis. Next, we used these mRNA and miRNA expression profiles of the TMZ resistant cells to generate miRNA/mRNA interaction networks using the integrative network tool mirConnX. This tool combines sequence information with gene expression data analysis to create a condition-specific regulatory network. Results: In the obtained mRNA/miRNA network of our TMZ resistant cell lines, we identified the plant homeodomain (PHD)-like finger 6 (PHF6) mRNA to be targeted by the largest set of miRNAs, i.e. miR-143, miR-93, miR-183, miR-96, and miR-214. Analysis of PHF6 mRNA expression in the TMZ resistant subclones by qRT-PCR showed an increased expression of this mRNA in four of six resistant subclones. Protein expression analysis of PHF6 in these cell lines showed a modest increase in four of the six resistant subclones. Furthermore, analysis of mRNA and protein expression levels of PHF6 in glioblastoma patient datasets showed increased expression of PHF6 in glioblastoma tissue compared to normal brain tissue. In addition, knockdown of PHF6 using siRNA in combination with TMZ enhanced the TMZ response. These results suggest that PHF6 is a candidate drug target for the potentiation of TMZ efficacy. Conclusion: Altogether, these results demonstrate that mirConnX is a useful tool to investigate miRNA/mRNA interactions in TMZ resistant cells and can be used to identify new potential drug targets. Citation Format: Lotte Hiddingh, Rajiv S. Raktoe, Gertjan J.L. Kaspers, W. Peter Vandertop, David P. Noske, Pieter Wesseling, Thomas Wurdinger. Identification of PHF6 as a temozolomide resistance factor in glioblastoma using mirConnX. [abstract]. In: Proceedings of the 105th Annual Meeting of the American Association for Cancer Research; 2014 Apr 5-9; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2014;74(19 Suppl):Abstract nr 3775. doi:10.1158/1538-7445.AM2014-3775
Review confirms workplace counselling reduces stress
Authors: Susan Mayor
Journal: BMJ (2001)

Counselling can achieve a reduction in work related stress in more than 50% of people, according to a systematic review published last week.

It showed that levels of work related symptoms and stress returned to the normal range for more than 50% of clients in two thirds of the studies included. Levels of sickness and absence also fell by 25-50% in trials evaluating these factors. Counselling interventions had smaller, but significant, positive effects on levels of job commitment, work functioning, job satisfaction, and substance misuse.

The report's author, Professor John McLeod, professor of counselling at the University of Abertay, Dundee, commented: “Taken as a whole, there are now several plausible studies that show …
Allogeneic Transplantation in First Remission Improves Outcome in Secondary Acute Myeloid Leukemia
Authors: Christer Nilsson, Erik Hulegårdh, Vladimir Lazarevic, Hege Garelius, Asa Rangert Derolf, Lars Möllgård, Lovisa Wennström, Bertil Uggla, Petar Antunovic, Kristina Myhr-Eriksson, Anders Wahlin, Martin Höglund, Gunnar Juliusson, Dick Stockelberg, Lehmann Soren
Journal: Blood (2014)
The Most Powerful Therapeutic Force
Authors: Joseph B Kirsner
Journal: JAMA (2002)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
snoRNA U17 Regulates Cellular Cholesterol Trafficking
Authors: Sarah Jinn, Katrina A. Brandis, Aileen Ren, Anita Chacko, Nicole Dudley-Rucker, Sarah E. Gale, Rohini Sidhu, Hideji Fujiwara, Hui Jiang, Brett N. Olsen, Jean E. Schaffer, Daniel S. Ory
Journal: Cell Metabolism (2015)
Suicide Among US Military Personnel
Authors: Philip M. Flatau
Journal: JAMA (2015)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Naval Hospital Ship Heads for Home After Treating Casualties of Gulf War
Authors: Brian Vastag
Journal: JAMA (2003)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Journals JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Final overall survival results of NEJ002, a phase III trial comparing gefitinib to carboplatin (CBDCA) plus paclitaxel (TXL) as the first-line treatment for advanced non-small cell lung cancer (NSCLC) with EGFR mutations.
Authors: A. Inoue, K. Kobayashi, M. Maemondo, S. Sugawara, S. Oizumi, H. Isobe, A. Gemma, Y. Saijo, H. Yoshizawa, S. Morita, K. Hagiwara, T. Nukiwa
Journal: Journal of Clinical Oncology (2011)

7519 Background: NEJ002 have demonstrated a significant superiority of gefitinib on progression-free survival compared with CBDCA plus PTX (CP) as the first-line treatment for EGFR-mutated advanced NSCLC. Since the result of overall survival (OS) was immature at the time of previous report, final evaluation of the updated OS was performed. Methods: OS at the final data-cut-off point (November 2010) was evaluated for the entire ITT population in NEJ002 (n=228). Subgroup analysis of OS for gender, smoking status, and type of mutation and detail examination for second or later-line chemotherapy on each patient were also performed. Results: The updated maturity of OS data was 60% compared to 36% at the previous cut-off point in November 2008. The median survival time and 2-year survival rate were 27.7 months and 57.9% in gefitinib group, and 26.6 months and 53.7% in CP group (HR 0.887; 95% CI 0.634-1.241; p=0.483). No significant difference in OS was observed between groups from any subset analysis. In gefitnib group, OS of patients with exon 19 deletion and that of patients with L858R were similar (28.9 months vs 28.0months). Eleven patients were still responding to the first-line gefitinib. Regarding the second-line treatment, 90% of patients in gefitinib group received chemotherapy and 96% of patients in CP group received gefitinib. Conclusions: No statistical difference in OS was observed in NEJ002 from this matured analysis, which is possibly due to high cross-over use of gefitinib in the CP group. Considering a risk-benefit balance and the results of QOL investigation in NEJ002, gefitinib should be considered as one of the standard first-line treatment for EGFR-mutated advanced NSCLC.
Kinetics of Cell Proliferation of Murine Bone Marrow Cells Cultured in Diffusion Chambers: Effect of Hypoxia, Bleeding, Erythropoietin Injections, Polycythemia, and Irradiation of the Host
Authors: Arne Boyum, Arland L. Carsten, Ole Didrik Laerum, Eugene P. Cronkite
Journal: Blood (1972)
Hepatitis A outbreak in a Roma village in eastern Slovakia, August-November 2008
Authors: L Hrivniaková, M Sláčiková, S Kolcunová
Journal: Eurosurveillance (2009)

We describe an outbreak of hepatitis A in Lomnicka, a village in the eastern part of Slovakia. The outbreak was limited to the village and did not spread either to other districts of Slovakia or to the neighbouring countries. The number of cases reported from 28 August to 30 November 2008 was 298. All cases but one occurred in the Roma population. The outbreak was associated with low socio-economic conditions which facilitated person-to-person transmission. No common source of the outbreak was verified.