tbuckley/cabot-search huggingface dataset:
Pulmonary hypertension in hydralazine induced systemic lupus erythematosus: association with C4 null allele.
Authors: R A Asherson, A G Benbow, C J Speirs, N Jackson, G R Hughes
Journal: Annals of the Rheumatic Diseases (1986)

A patient who developed pulmonary hypertension and systemic lupus erythematosus as a complication of hydralazine therapy is reported. She was a slow acetylator and in addition was found to have a null allele at the C4A locus.
Health care in London. BMA slow to condemn Tomlinson.
Authors: C Nagpaul
Journal: BMJ (1993)

Health care in LondonOther cities also overbedded EDITOR,-Brian Jarman takes issue with the recommendations of the Tomlinson report and the government's response, which have suggested the closure of several hospitals in London, by arguing that the data on provision and use of beds in all specialties by London residents do not amount to a case for reducing the total stock of hospital beds in London at a rate faster than elsewhere.'He shows
Harnessing Hedgehog for the Treatment of Basal Cell Carcinoma
Authors: Kelly L. Harms, Andrzej A. Dlugosz
Journal: JAMA Dermatology (2013)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Dermatology HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Dermatology journal
Primary malignant melanoma with surrounding melanosis in the anorectum
Authors: J. Kim, B. Keum, Y. Seo, Y. Kim, Y. Jeen, H. Chun, S. Um, C. Kim, H. Ryu
Journal: Endoscopy (2010)

A 76-year-old woman presented to the emergency room with hematochezia. Apart from a low hemoglobin level (8.9 g/dL), laboratory findings were unremarkable. On colonoscopy, a large mass with a dark-stained surface was observed extending from the anus up to 3 cm above the anal verge ([Fig. 1]).
The effect of inositol supplements on the psoriasis of patients taking lithium: a randomized, placebo-controlled trial
Authors: S.J.R. Allan, G.M. Kavanagh, R.M. Herd, J.A. Savin
Journal: British Journal of Dermatology (2004)

Background Lithium carbonate is the most widely used long‐term treatment for bipolar affective disorders, but its ability to trigger and exacerbate psoriasis can become a major problem in patients for whom lithium is the only treatment option. Inositol depletion underlies the action of lithium in bipolar affective disorders and there are good theoretical reasons why the use of inositol supplements might be expected to help this group of patients. Objectives To determine whether inositol supplements improve the psoriasis of patients on lithium therapy. Methods Fifteen patients with psoriasis, who were taking lithium, took part in a randomized, double‐blind, placebo‐controlled, crossover clinical trial comparing the effect of inositol supplements with those of a placebo (lactose). Changes in the severity of their psoriasis were measured by Psoriasis Area and Severity Index scores recorded before and after the different courses of treatment. The effect of inositol supplements on the psoriasis of 11 patients who were not taking lithium was evaluated in the same way. Results The inositol supplements had a significantly beneficial effect on the psoriasis of patients taking lithium. No such effect was detected on the psoriasis of patients not on lithium. Conclusions The use of inositol supplements is worth considering for patients with intractable psoriasis who need to continue to take lithium for bipolar affective disorders.
France challenges patent for genetic screening of breast cancer
Authors: A. Dorozynski
Journal: BMJ (2001)

The Institut Curie, France's top centre for research, diagnosis, and treatment of cancer, is challenging the patent awarded by the European patent office to the US company Myriad Genetics, of Salt Lake City, Utah, for a test to screen for predisposition to breast cancer.

The patent, granted last January, covers the BRCA1 gene. The French ministry of health and the ministry of research support the institute's initiative, claiming that the patent gives Myriad an abusive monopoly and threatens basic research. …
LOCHGOILHEAD FEVER: OUTBREAK OF NON-PNEUMONIC LEGIONELLOSIS DUE TO LEGIONELLA MICDADEI
Authors: DavidJ. Goldberg, PeterW. Collier, RonaldJ. Fallon, ThomasM. Mckay, TerenceA. Markwick, JohnG. Wrench, JohnA. Emslie, GeraldI. Forbes, AgnesC. Macpherson, Daniel Reid
Journal: The Lancet (1989)
Letters to the Editor and Informed Consent
Authors: DAVID NAYLOR
Journal: Annals of Internal Medicine (1985)

Letters and Corrections1 April 1985Letters to the Editor and Informed ConsentDAVID NAYLOR, M.D., D. Phil.DAVID NAYLOR, M.D., D. Phil.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-102-4-564_1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: A recent letter from Sesoko and colleagues (1) described the case of a 28-year-old man who presented with complaints of headaches and blurred vision and was found to have renal impairment, papilledema, and a blood pressure of 200/140 mm Hg. Most internists would consider this a serious medical problem requiring urgent management. Atropine, which has no place in the treatment of severe hypertension, was given intravenously on an experimental basis. Consequently, the patient had a marked and sudden elevation in blood pressure together with symptoms indicating that vital organ systems were put at grave risk by the...Reference1. SESOKOMIYAZAKIKATOTOCHIKUBOKANEKO SNYOY. Atropine and hypertensive crisis [Letter] Ann Intern Med. 1984; 101:720. LinkGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 April 1985Volume 102, Issue 4Page: 564-564KeywordsAtropineBlood pressureHypertensionVision Issue Published: 1 April 1985 PDF downloadLoading ...
Esterified eicosanoids are acutely generated by 5-lipoxygenase in primary human neutrophils and in human and murine infection
Authors: Stephen R. Clark, Christopher J. Guy, Martin J. Scurr, Philip R Taylor, Ann P. Kift-Morgan, Victoria J. Hammond, Christopher P. Thomas, Barbara Coles, Gareth W. Roberts, Matthias Eberl, Simon A. Jones, Nicholas Topley, Sailesh Kotecha, Valerie B. O'Donnell
Journal: Blood (2010)
Screening Adolescents for Sexually Transmitted Infections
Authors: Donald P. Orr
Journal: JAMA (1998)

Genital infections due to Chlamydia trachomatis are a serious public health problem in the United States. Chlamydia infections remain the most common treatable sexually transmitted infection (STI), with highest prevalence among adolescent females, 1 although the disease prevalence is declining. 2 Screening and treating sexually active adolescent females for C trachomatis reduce the disease prevalence and prevent complications such as pelvic inflammatory disease. 3,4 Modeling studies estimate that screening is cost-effective under widely varying circumstances. The benefits depend on the prevalence of infection in the population and the specific diagnostic test used. 5 Efforts to identify criteria for targeted screening uniformly find age to be the most important risk factor. Moreover, chlamydia reinfection—often within a few months of initial infection—is common and increases the risk of pelvic inflammatory disease. 6 These findings are the basis for recommendations of routine annual screening for sexually active adolescent females younger than 20 years. 7
Graves Disease in a US Army Special Forces Group
Authors: Henry B. Burch, Victor J. Bernet, Frederic R. Plotkin, Cedric F. McCord, Robin S. Howard, Barbara L. Solomon, William P. Magdycz, Stephen C. Craig
Journal: JAMA (2002)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue
Functional interaction between Wnt3 and Frizzled-7 leads to activation of the Wnt/β-catenin signaling pathway in hepatocellular carcinoma cells
Authors: Miran Kim, Han Chu Lee, Orkhontuya Tsedensodnom, Rochelle Hartley, Young-Suk Lim, Eunsil Yu, Philippe Merle, Jack R. Wands
Journal: Journal of Hepatology (2008)
Psychopathy and violence: Arousal, temperament, birth complications, maternal rejection, and prefrontal dysfunction
Authors: Adrian Raine
Journal: Behavioral and Brain Sciences (1995)

Abstract The key questions arising from Mealey's analysis are: Do environmental factors such as early maternal rejection also contribute to the emotional deficits observed in psychopaths? Are there psychophysiological protective factors for antisocial behavior that have clinical implications? Does a disinhibited temperament and low arousal predispose to primary psychopathy? Would primary or secondary psychopaths be most characterized by prefrontal dysfunction?
Diuretic-Induced Renal Colic
Authors: Allen F. Delevett
Journal: JAMA (1973)

<h3>To the Editor.—</h3> Two articles report<sup>1,2</sup>water- and beer-induced diuresis precipitating attacks of renal colic in patients with intermittent hydronephrosis. Here is an account of renal colic resulting from drug-induced diuresis. This response led to the discovery of previously asymptomatic partial urinary tract obstruction. <h3>Report of a Case.—</h3> A 43-year-old white woman with a uterine fibroid known since the age of 38, at an annual examination in 1972 complained of premenstrual edema with a weight gain of five pounds, tenderness of the breasts, and general body heaviness. No abdominal, back, or flank complaints appeared, nor had they on previous examinations dating back to 1960. Menstrual cycles were normal and not prolonged. A large irregular uterus extended into the right lower quadrant of the abdomen. A combination of 50 mg of triamterene (Dyrenium) and 25 mg of hydrochlorothiazide was prescribed every other morning beginning ten days before each period, as
Thyroid Therapy in Gynecologic Abnormalities
Authors: C. L. Buxton, F. H. Vann
Journal: New England Journal of Medicine (1948)

FOR a number of years it has been the impression of obstetricians and gynecologists that lack of thyroid activity has a definite influence on the production of menstrual and obstetric abnormalities.It has been said that "the relation of the thyroid gland to the sex organs is the most ancient and classical interrelation of the functions of the glands of internal secretion. Known to the ancients and a subject of daily gossip, it has passed down through the ages."1 In 1926 Litzenberg2 noted the frequency of low basal metabolic rates in patients complaining of sterility and menstrual abnormalities, and in . . .
STATUS OF GASTRODUODENAL ULCER
Authors: Jesse P. Eddy
Journal: JAMA (1942)

<h3>To the Editor:—</h3> I have been much interested in the editorial inThe JournalApril 25 entitled "Status of Gastroduodenal Ulcer." It emphasizes a point which has not been particularly stressed in recent years, namely the effect of hypersecretion and hyperacidity on the ulcer patient. The editorial strongly suggests and marshals evidence to prove that just such an increase in the acidity and secretion of the stomach predisposes to ulceration, prolongs the attack and favors recurrence. With this view I am heartily in accord. It is probably true that gastroduodenal ulcer is primarily a medical problem, but I think that we may now add another surgical indication for duodenal ulcer: persisting hyperacidity and hypersecretion. By some this may be included under the heading of intractability; but, as intractability is a broad, general, nonspecific term, it would seem to be far more scientific and definite to recognize the pathologic-physiologic state of
Surgery of the Biliary Tract
Authors: R. Dale Liechty
Journal: JAMA (1976)

Surgeons in the United States remove over 300,000 gallbladders yearly and, according to the author, injure at least 1,000 common bile ducts while performing these procedures. In terms of numbers alone, a volume on biliary tract surgery should arouse our interest. But despite much practical information, this book lacks depth at some points of greatest current interest. For example, the author "prefers to reoperate on the patient..." (with retained common bile duct stones). He fails to cite Burhenne's outstanding success in extracting retained stones from 95 of 100 patients—without anesthesia or premedication. Featuring a modified Dormia basket, this technique, which has been adopted by many other radiologists, promises to save many operations and lives among the 5,000 patients yearly who suffer from overlooked stones. The preface, but not the title, tells us that this is an "adults only" book, so the reader who races into the text after noting only
Annual Meeting: Perspectives
Authors: Keith Wrenn
Journal: Annals of Internal Medicine (1996)

Medicine and Public Issues15 May 1996Annual Meeting: PerspectivesKeith Wrenn, MDKeith Wrenn, MDVanderbilt University Medical Center Nashville, TN 37232-4700Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-124-10-199605150-00012 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail He was early. No one besides the audiovisual guy was there. It was a big room with several hundred uncomfortable chairs, all too close together. He chose one on the aisle about halfway back. The temperature was just a little too chilly. As he sat down, he sighed with relief.He was a general internist in a town with one red light. Getting here had been frustrating. First, he'd spent the last 2 weeks working extra hard, trying to keep his chronically ill patients doing as well as they could, out of the hospital. The last week had been a ... Author, Article, and Disclosure InformationAuthors: Keith Wrenn, MDAffiliations: Vanderbilt University Medical Center Nashville, TN 37232-4700Corresponding Author: Keith Wrenn, MD, 703 Oxford House, Vanderbilt University Medical Center, Nashville, TN 37232-4700. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 15 May 1996Volume 124, Issue 10Page: 924KeywordsCell culturesFeversGamesInpatientsIschemiaMedical educationScientistsSleepTaxesTemperature ePublished: 15 August 2000 Issue Published: 15 May 1996 Copyright & PermissionsCopyright © 1996 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
HEAD REST FOR GANGLION OPERATION
Authors: Alfred W. Adson
Journal: JAMA (1922)

A head rest for use in a ganglion operation should be easily adjusted and applied to the head, and at the same time hold the head firmly during the operation without producing undue pressure on any particular part of the head. Such a head rest (Figs. 1 and 2) has been developed and used satisfactorily in many ganglion operations. The head rest may be slipped on a Balfour operating table, but if the distance between the bar arms is varied (<i>M</i>, Fig. 1) it will fit any operating table; it is adjusted with two universal joints so that the head can be raised, lowered, or tilted from side to side as the surgeon desires. It is especially designed to support the patient's head, gently yet securely, during a ganglion operation in such a manner that the field of operation is wholly unobstructed. In Figure 1 the two pads<i>A</i>are
Suppression of arthritic bone destruction by adenovirus-mediated csk gene transfer to synoviocytes and osteoclasts
Authors: Hiroshi Takayanagi, Takuo Juji, Tsuyoshi Miyazaki, Hideharu Iizuka, Tokiharu Takahashi, Masashi Isshiki, Masato Okada, Yoshiya Tanaka, Yasuko Koshihara, Hiromi Oda, Takahide Kurokawa, Kozo Nakamura, Sakae Tanaka
Journal: Journal of Clinical Investigation (1999)

Rheumatoid arthritis (RA) is characterized by a chronic inflammation of the synovial joints resulting from hyperplasia of synovial fibroblasts and infiltration of lymphocytes, macrophages, and plasma cells, all of which manifest signs of activation. Recent studies have revealed the essential role of osteoclasts in joint destruction in RA. Src family tyrosine kinases are implicated in various intracellular signaling pathways, including mitogenic response to growth factors in fibroblasts, activation of lymphocytes, and osteoclastic bone resorption. Therefore, inhibiting Src activity can be a good therapeutic strategy to prevent joint inflammation and destruction in RA. We constructed an adenovirus vector carrying the csk gene, which negatively regulates Src family tyrosine kinases. Csk overexpression in cultured rheumatoid synoviocytes remarkably suppressed Src kinase activity and reduced their proliferation rate and IL-6 production. Bone-resorbing activity of osteoclasts was strongly inhibited by Csk overexpression. Furthermore, local injection of the virus into rat ankle joints with adjuvant arthritis not only ameliorated inflammation but suppressed bone destruction. In conclusion, adenovirus-mediated direct transfer of the csk gene is useful in repressing bone destruction and inflammatory reactions, suggesting the involvement of Src family tyrosine kinases in arthritic joint breakdown and demonstrating the feasibility of intervention in the kinases for gene therapy in RA. off
Abstract 21: Elevated Resting Heart Rate Is Associated with Pulseless Electrical Activity Independent of {beta}-Blocker Use
Authors: Carmen Teodorescu, Kyndaron Reinier, Audrey Uy-Evanado, Jo Ayala, Ronald Mariani, Harpriya Chugh, Mohamud Daya, Karen Gunson, Jonathan Jui, Sumeet S Chugh
Journal: Circulation (2011)

Introduction: Higher heart rate (HR) has been associated with increased cardiovascular mortality but mechanisms are poorly understood. Sudden cardiac arrest (SCA) presenting with pulseless electric...
Dads, Docs, Drugs, and Decisions
Authors: James T. Lehner
Journal: JAMA (1992)

To the Editor.  —I could not agree with the conclusions of Drs LaPuma and Priest 1 any more strongly. It is common for us to treat our own family members, particularly our children, for what we consider routine exams, especially when this involves filling out forms for athletic, school, or employment physicals.  Recently, my oldest daughter, a healthy-looking 21-year-old and a senior in college, needed a physical examination as part of postgraduate pursuit. In bold letters on the top of the physical examination sheet was printed May Not Be Completed by a Family Member. With this, my daughter went to our family physician who performed a thorough examination. He found a very small lump at the base of her neck. I found the lump difficult to even feel, and I am quite sure I would have discounted it on my examination. After a few weeks, definitive diagnosis of stage II
Exercise tests. A survey of procedures, safety, and litigation experience in approximately 170,000 tests
Authors: Paul Rochmis, Henry Blackburn
Journal: JAMA (1971)

This report surveys the techniques, safety and litigation experience of 170,000 exercise stress tests performed in 73 medical centers. Procedures and results varied but certain patterns emerged: (1) A medical history was required before testing in 89% of centers, a physical examination in 97%, and a resting electrocardiogram in 57%. (2) Active cardiac disease precluded testing. (3) Informed consent was sought in 75% and was required in written form in 30%. (4) Specific test-interruption criteria involved symptoms, signs, and ECG findings. (5) Progressive workloads were employed by 73%. (6) Full resuscitation facilities were available. (7) The mortality was about 1 per 10,000 tests (16 per 170,000). (8) Combined mortalitymorbidity was about 4 per 10,000 tests. (9) Mortality was not clearly related to type of test. (10) Successful litigation, with an out-of-court settlement was reported in one instance.
Identification of transcripts overexpressed during airway epithelium differentiation
Authors: B. Chhin, J. T. Pham, L. El Zein, K. Kaiser, O. Merrot, P. Bouvagnet
Journal: European Respiratory Journal (2008)

Human airway epithelium, the defence at the forefront of protecting the respiratory tract, evacuates inhaled particles by a permanent beating of epithelial cell cilia. When deficient, this organelle causes primary ciliary dyskinesia, and, despite numerous studies, data regarding ciliated cell gene expression remain incomplete. The aim of the present study was to identify genes specifically expressed in human ciliated respiratory cells via transcriptional analysis. The transcriptome of dedifferentiated epithelial cells was subtracted from that of fully redifferentiated cells using complementary DNA representational difference analysis. In order to validate the results, gene overexpression in ciliated cells was confirmed by real-time PCR, and by comparing the present list of genes overexpressed in ciliated cells to lists obtained in previous studies. A total of 53 known and 12 unknown genes overexpressed in ciliated cells were identified. The majority (66%) of known genes had never previously been reported as being involved in ciliogenesis, and the unknown genes represent hypothetical novel transcript isoforms or new genes not yet reported in databases. Finally, several genes identified here were located in genomic regions involved in primary ciliary dyskinesia by linkage analysis. In conclusion, the present study revealed sequences of new cilia-related genes, new transcript isoforms and novel genes which should be further characterised to aid understanding of their function(s) and their probable disorder-related involvement.