Albright's Hereditary Osteodystrophy
Authors: A. ROBERT ARNSTEIN
Journal: Annals of Internal Medicine (1966)

Article1 May 1966Albright's Hereditary OsteodystrophyReport of a Family with Studies of Bone RemodelingA. ROBERT ARNSTEIN, M.D., BOY FRAME, M.D., F.A.C.P., HAROLD M. FROST, M.D., MELVIN A. BLOCK, M.D.A. ROBERT ARNSTEIN, M.D.Search for more papers by this author, BOY FRAME, M.D., F.A.C.P.Search for more papers by this author, HAROLD M. FROST, M.D.Search for more papers by this author, MELVIN A. BLOCK, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-64-5-996 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe original prediction (1, 2) of the importance of genetic factors in pseudohypoparathyroidism and its relationship to pseudopseudohypoparathyroidism is proving to be correct as increasing reports of familial occurrence are appearing. The subject has been thoroughly discussed in the recent review by Mann, Alterman, and Hill (3), who have proposed that the term "Albright's hereditary osteodystrophy" be adopted to encompass the classical forms of pseudohypoparathyroidism and pseudo-pseudohypoparathyroidism as well as various forms of partial expression of the syndrome. This report adds 1 family to the 22 collected by Mann and associates (3) and provides new observations on bone remodeling dynamics...References1. ELRICKALBRIGHTBARTTERFORBESREEVES HFFCAPJD: Further studies on pseudohypoparathyroidism: report of four new cases. Acta Endocr. (Kobenhavn) 5: 199, 1950. CrossrefMedlineGoogle Scholar2. ALBRIGHTFORBESHENNEMAN FAPPH: Pseudo-pseudohypoparathyroidism. Trans. Ass. Amer. Physicians 65: 337, 1952. MedlineGoogle Scholar3. MANNALTERMANHILLS JBSAG: Albright's hereditary osteodystrophy comprising pseudohypoparathyroidism and pseudo-pseudohypoparathyroidism. With a report of two cases representing the complete syndrome occurring in successive generations. Ann. Intern. Med. 56: 315, 1962. LinkGoogle Scholar4. ELLSWORTHHOWARD RJE: Studies on the physiology of the parathyroid glands. VII. Some responses of normal human kidneys to intravenous parathyroid extract. Bull. Hopkins Hosp. 55: 296, 1934. Google Scholar5. HOWARDHOPKINSCONNOR JETRTB: On certain physiologic responses to intravenous infusion of calcium salts into normal, hyperparathyroid and hypoparathyroid persons. J. Clin. Endocr. 13: 1, 1953. CrossrefMedlineGoogle Scholar6. JONESFOURMAN KHP: Edetic-acid test of parathyroid insufficiency. Lancet 2: 119, 1963. CrossrefMedlineGoogle Scholar7. MILCHRALLTOBIE RADPJE: Bone localization of the tetracyclines. J. Nat. Cancer Inst. 19: 87, 1957. MedlineGoogle Scholar8. KLEINVILLANEUVAFROST MARHM: A quantitative histological study of rib from 18 patients treated with adrenal cortical steroids. Acta Orthop. Scand. 35: 171, 1965. CrossrefMedlineGoogle Scholar9. FROST HM: Mathematical Elements of Lamellar Bone Remodelling. Charles C Thomas, Publisher, Springfield, Ill., 1964. Google Scholar10. TASHJIANLEVINEMUNSON AHLPL: Immunoassay of parathyroid hormone by quantitative complement fixation. Endocrinology 74: 244, 1964. CrossrefMedlineGoogle Scholar11. BERSONYALOWAURBACHPOTTS SARSGDJT: Immunoassay of bovine and human parathyroid hormone. Proc. Nat. Acad. Sci. U.S.A. 49: 613, 1963. CrossrefMedlineGoogle Scholar12. SEDLIN ED: The ratio of cortical area to total cross-section area in rib diaphysis: a quantitative index of osteoporosis. Clin. Orthop. 36: 161, 1964. Google Scholar13. FROST HM: Human osteoid seams. J. Clin. Endocr. 22: 631, 1962. CrossrefGoogle Scholar14. FROST HM: Measurement of human bone formation by means of tetracycline labelling. Canad. J. Biochem. 41: 31, 1963. MedlineGoogle Scholar15. LANDEROSFROST OHM: A cell system in which rate and amount of protein synthesis are separately controlled. Science 145: 1323, 1964. CrossrefMedlineGoogle Scholar16. TAKAHASHIFROST HHM: Lamellar bone physiology in diabetes mellitus: the kinetics of the resorption process in cortical remodelling in diabetic ribs. Henry Ford Hosp. Med. Bull. 12: 537, 1964. Google Scholar17. PALUBINSKASDAVIES AJH: Calcification of the basal ganglia of the brain. Amer. J. Roentgen. 82: 806, 1959. Google Scholar18. GERSHBERGWESELEY HAC: Pseudo-hypoparathyroidism and pregnancy. Is pseudo-pseudohypoparathyroidism a mild form of pseudohypoparathyroidism? J. Pediat. 56: 383, 1960. CrossrefMedlineGoogle Scholar19. HERMANSGORMANMARTINKELLY PECAWJPJ: Pseudo-pseudohypoparathyroidism (Albright's hereditary osteodystrophy): a family study. Mayo Clin. Proc. 39: 81, 1964. MedlineGoogle Scholar20. MACKLERFOUTSBIRSNER HJRJW: Familial pseudohypoparathyroidism. Calif. Med. 77: 332, 1952. MedlineGoogle Scholar21. BUCHS S: Familiärer pseudohypoparathyroidismus. Ann. Paediat. (Basel) 183: 65, 1954. MedlineGoogle Scholar22. MINOZZIFAGGIANOBIANCOBRIZZICOLIGIANNI MMAGA: Su un caso di osteodistrofia erediteria di Albright, varieta normocalcemia, con documentata trasmissione da maschio a maschio. Folia Endocr. (Roma) 16: 168, 1963. Google Scholar23. ARCHIBALDFINBYDEVITO RMNF: Endocrine significance of short metacarpals. J. Clin. Endocr. 19: 1312, 1959. CrossrefGoogle Scholar24. BRAILSFORD JF: Familial brachydactyly. Brit. J. Radiol. 18: 167, 1945. CrossrefGoogle Scholar25. UHRBEZAHLER NHB: Pseudo-pseudohypoparathyroidism: report of three cases in one family. Ann. Intern. Med. 54: 443, 1961. LinkGoogle Scholar26. JACKSON WP: Steatorrhea and hypoparathyroidism. Lancet 1: 1086, 1957. CrossrefGoogle Scholar27. BERNSTEINKLEEMANDOWLINGMAXWELL DCRJTMH: Steatorrhea, functional hypoparathyroidism, and metabolic bone defect. Arch. Intern. Med. (Chicago) 109: 43, 1962. CrossrefMedlineGoogle Scholar28. FRAMEFRUCHTMANSMITH BMRW: Chronic hypocalcemia in a patient with parathyroid clear-cell hyperplasia. New Eng. J. Med. 267: 1112, 1962. CrossrefMedlineGoogle Scholar29. BELLGERARDBARTTER NHESFC: Pseudohypoparathyroidism with osteitis fibrosa cystica and impaired absorption of calcium. J. Clin. Endocr. 23: 759, 1963. CrossrefGoogle Scholar30. FRAMEFROST BHM: Unpublished observations, 1965. Google Scholar31. KOLBSTEINBACH FOHL: Pseudohypoparathyroidism with secondary hyperparathyroidism and osteitis fibrosa. J. Clin. Endocr. 22: 59, 1962. CrossrefGoogle Scholar32. SINGLETONTENG EBCT: Pseudohypoparathyroidism with bone changes simulating hyperparathyroidism. Report of a case. Radiology 78: 388, 1962. CrossrefMedlineGoogle Scholar33. COSTELLODENT JMCE: Hypo-hyperparathyroidism. Arch. Dis. Child. 38: 397, 1963. CrossrefMedlineGoogle Scholar34. MACGREGORWHITEHEAD METP: Pseudohypoparathyroidism. A description of 3 cases and a critical appraisal of earlier accounts of the disease. Arch. Dis. Child. 29: 398, 1954. CrossrefMedlineGoogle Scholar35. SURKSLEVENSON MID: Pseudohypoparathyroidism. Case report with observations on the difficulty in confirming the diagnosis. Ann. Intern. Med. 56: 282, 1962. LinkGoogle Scholar36. DENT CE: Discussion on the physiology and clinical disorders of the parathyroid glands. Proc. Roy. Soc. Med. 46: 291, 1953. CrossrefMedlineGoogle Scholar37. HIATTTHOMPSON HHDD: The effects of parathyroid extract on renal function in man. J. Clin. Invest. 36: 557, 1957. CrossrefMedlineGoogle Scholar38. BETHUNESMITHINONE JELFH: Renal phosphaturic response to parathyroid hormone administration and dietary intake of phosphorus in man. J. Clin. Endocr. 24: 1103, 1964. CrossrefGoogle Scholar39. DANCASTERSCHENDELJACKSON CPHEWP: Response to prolonged intramuscular administration of parathyroid hormone in the normal human subject. Clin. Sci. 19: 563, 1960. MedlineGoogle Scholar40. BRONSKYKUSHNERDUBINSNAPPER DDSAL: Idiopathic hypoparathyroidism and pseudohypoparathyroidism: case reports and review of the literature. Medicine (Balt.) 37: 317, 1958. CrossrefMedlineGoogle Scholar41. GARCEAUMILLER GJWE: Osteochondrodystrophy as a result or in relation to pseudohypoparathyroidism. J. Bone Joint Surg. [Amer.] 38: 131, 1956. CrossrefGoogle Scholar42. DOTYYATESLOTZKISECLESKITALMAGE SBCWWEWRV: Effect of short term alpha irradiation on parathyroid activity and osteoclast numbers. Proc. Soc. Exp. Biol. Med. 119: 77, 1965. CrossrefMedlineGoogle Scholar43. ALBRIGHTBURNETTSMITHPARSON FCHPHW: Pseudohypoparathyroidism—an example of the "Seabright-Bantam syndrome." Endocrinology 30: 922, 1942. Google Scholar44. RASMUSSENDELUCAARNAUDHAWKERVON STEDINGK HHCCM: The relationship between vitamin D and parathyroid hormone. J. Clin. Invest. 42: 1940, 1963. CrossrefMedlineGoogle Scholar45. HARRISONHARRISON HEHC: The interaction of vitamin D and parathyroid hormone on calcium, phosphorus and magnesium homeostasis in the rat. Metabolism 13: 952, 1964. CrossrefMedlineGoogle Scholar46. TOVERUD SU: The effect of parathyroid hormone and vitamin D on serum calcium in rats. Acta Physiol. Scand. 62: 391, 1964. CrossrefMedlineGoogle Scholar47. COPP DH: Parathyroids, calcitonin and control of plasma calcium. Rec. Prog. Horm. Res. 20: 59, 1964. MedlineGoogle Scholar48. HIRSCHGAUTHIERMUNSON PFGFPL: Thyroid hypocalcemic principle and recurrent laryngeal nerve injury as factors affecting the response to parathyroidectomy in rats. Endocrinology 73: 244, 1963. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Detroit, MichiganFrom the Henry Ford Hospital, Detroit, Mich.Requests for reprints should be addressed to A. Robert Arnstein, M.D., Department of Medicine, Henry Ford Hospital, Detroit, Mich. 48202. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByAlbright's hereditary osteodystrophy: A reviewALBRIGHT'S HEREDITARY OSTEODYSTROPHYEquilibrium and disequilibrium hypercalcemia new light on an old conceptHypoparathyroidismThe Genetic Aspects of Facial AbnormalitiesThe actions of parathyroid hormone on bone: Relation to bone remodeling and turnover, calcium homeostasis, and metabolic bone diseaseRecent Progress in Osteomalacia and RicketsA. ROBERT ARNSTEIN, M.D., BOY FRAME, M.D., F.A.C.P., HAROLD M. FROST, M.D.The Hereditary Renal DiseasesLessons from Inborn Errors of Metabolism 1 May 1966Volume 64, Issue 5Page: 996-1008KeywordsBone remodelingGeneticsPseudohypoparathyroidism Issue Published: 1 May 1966 PDF DownloadLoading ...