THROMBOTIC THROMBOCYTOPENIC PURPURA WITH EXTENSIVE HEMORRHAGIC GANGRENE OF THE SKIN AND SUBCUTANEOUS TISSUE: REPORT OF A CASE
Authors: William F. Luttgens
Journal: Annals of Internal Medicine (1957)

Case Reports1 June 1957THROMBOTIC THROMBOCYTOPENIC PURPURA WITH EXTENSIVE HEMORRHAGIC GANGRENE OF THE SKIN AND SUBCUTANEOUS TISSUE: REPORT OF A CASEWILLIAM F. LUTTGENSWILLIAM F. LUTTGENSSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-46-6-1207 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptNo reports of this complication of thrombotic thrombocytopenic purpura were found in a review of the literature. Somewhat similar skin lesions were described, however, in two cases in which the patients eventually recovered. In the case reported by Jernigan and Farber1there were many features in common with the case herein reported. In the case they described, a 36 year old woman had recurrent malaise, chills, fever, thrombocytopenia, anemia, leukopenia, and hemorrhagic necrosis of the skin and subcutaneous tissue over a period of four years. There was good response to cortisone in a dosage up to 800 mg. daily. Skin...Bibliography1. JerniganFarber JAEM: Panniculitis with hemorrhagic necrosis and pancytopenia, Stanford M. Bull. 13: 11, 1955. MedlineGoogle Scholar2. Dawson RL: Report of a case of recurrent cutaneous and subcutaneous gangrene, Brit. J. Plast. Surg. 4: 139, 1951. CrossrefMedlineGoogle Scholar3. Singer K: Thrombotic thrombocytopenic purpura, in Advances in internal medicine, Vol. VI, 1954, Yearbook Publishers, Chicago. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: (MC) USAR San Francisco, California*Received for publication January 30, 1956.From the Medical Service, Madigan Army Hospital, Tacoma, Washington.Requests for reprints should be addressed to William F. Luttgens, M.D., 655 Sutter Street, San Francisco 2, California. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byPurpura FulminansClinical cardiac involvement in thrombotic thrombocytopenic purpura: a systematic reviewRedefining the Syndromes of Thrombotic MicroangiopathyThe understanding of thrombotic thrombocytopenic purpura: Dyadic, triadic, pentadic, and other manifestationsVarious Clinical Manifestations in Patients with Thrombotic MicroangiopathyAcute Respiratory Distress Syndrome as a Major Clinical Manifestation of Thrombotic Thrombocytopenic PurpuraAcute respiratory distress syndrome and non-occlusive mesenteric ischemia as major clinical manifestations of thrombotic thrombocytopenic purpura: Complete remission following exchange plasmapheresisThe hemolytic uremic syndrome presenting as bilateral leg ischemiaIntravascular coagulation necrosis of the skin associated with cryofibrinogenemia, diabetes mellitus, and cardiolipin autoantibodiesBIBLIOGRAPHYON THE VASCULAR LESIONS OF THROMBOTIC THROM-BOCYTOPENIC PURPURA WITH SPECIAL REFERENCE TO ITS PATHOGENESIS*Microangiopathic Hemolytic Anemia Caused by Purpura FulminansJOHN H. HOLLINGSWORTH, M.D., DANIEL N. MOHLER, M.D., F.A.C.P.Thrombotic thrombocytopenic purpuraGangrenous Skin Lesions Associated with Chronic Ulcerative ColitisPhysiologic aspects of intravascular clotting∗ 1 June 1957Volume 46, Issue 6Page: 1207-1213KeywordsAnemiaEndocarditisFeversLesionsMedical servicesNecrosisThrombotic thrombocytopenic purpura ePublished: 1 December 2008 Issue Published: 1 June 1957 PDF downloadLoading ...