The Pituitary Factor in Arteriosclerosis Its Experimental Production in Rabbits
Authors: Robert C. Moehlig, Eugene A. Osius
Journal: Annals of Internal Medicine (1930)

Article1 December 1930The Pituitary Factor in Arteriosclerosis Its Experimental Production in RabbitsROBERT C. MOEHLIG, M.D., EUGENE A. OSIUS, M.D.ROBERT C. MOEHLIG, M.D.Search for more papers by this author, EUGENE A. OSIUS, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-4-6-578 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptExperimental production of arteriosclerosis in rabbits has been accomplished by several workers. Anitschkow and Chalatow1, Bailey2 and others, have used various sorts of diets high in fats or fat-like substances to produce these changes.Certain facts led us to approach the problem from a new angle. The relationship between the pituitary gland and fat and carbohydrate metabolism suggested that the pituitary secretion might be concerned in arteriosclerosis.While the exact pathogenesis of arteriosclerosis is somewhat in doubt, nevertheless the cholesterol infiltration of the blood vessels is definitely established.The importance of the suprarenal cortex in cholesterol metabolism is well recognized....References ANITSCHKOWCHALATOW NS: Uber experimentelle Cholesterinsteatose und ihre Bedeutung für die Entstehung einiger. pathologischer Prozesse. Centralbl. f. allg. Path. u. Anat. 24:1, 1913. Google Scholar BAILEY CH: Atheroma and Oother Lesions Produced in Rabbits by Cholesterol Feeding. J. Exper. Med. 23:69, 1916. CrossrefMedlineGoogle Scholar GOLDZIEHER M: The Adrenals. The Macmillan Co., New York, 1929, p. 250-251. Google Scholar MOEHLIG RC: A Study of the Ductless Glands: Detroit Med. J. 14:268, 1914; Ductless Gland Cell Control, Monograph, 1918, p. 87; Selective Tissue Action of Posterior Pituitary Gland: Med. Jour. and Rec. 120, (August 20) 55, 1924. Selective Action of the Suprarenal Cortex on Mesothelial Tissues: Am. J. M. Sc. 168, 553, 1924. Embryohormonic Relations of the Pituitary Gland to Mesenchymal Tissues; Ann. Int. Med. 1:563, 1928. Embryohormonic Relations of the Suprarenal Cortex to Mesothelial Tissues: Ann. Int. Med. 1:828, 1928; Pituitary Gland and Suprarenal Cortex, Arch. Int. Med. 44:339, 1929. Google Scholar MOEHLIGAINSLEE RCH: Posterior Pituitary Extract and Cholesterol Metabolism, Am. J. Physiol. 80:649, 1927. Pituitary Gland and Cholesterol Metabolism: Ann. Clin. Med. 5:772, 1927. CrossrefGoogle Scholar KROGH A: The Capillaries. Yale Press, 1922. Google Scholar SHAPIRO S: The Relation of Certain Glands of Internal Secretion to the Development of Atherosclerosis. Endocrinology, 11:279, 1927. CrossrefGoogle Scholar SACKETT GE: Modification of Bloor's Method for Determination of Cholesterol in Whole Blood or Blood serum. Jour. Biol. Chem. 64:203, 1925. CrossrefGoogle Scholar ISCOVESCO H: Sur les propriétés d'un lipoïde Extrait de la partie corticale des capsules surrénales, Compt. rend. Soc. Biol. 75:510, 1913. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Detroit, Michigan*This work was carried out with the assistance of the technical staff of Harper Hospital laboratory. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byArteriosklerose und Innere SekretionDie Krankheiten des HypophysenzwischenhirnsystemsDie Bedeutung der Hypophyse für die Pathologie der BlutgefäßeCongenital medial sclerosis of the coronary artery 1 December 1930Volume 4, Issue 6Page: 578-592KeywordsBlood vesselsCarbohydrate metabolismCholesterolDietFatsPathogenesisPituitary glandRabbitsResearch laboratories ePublished: 1 December 2008 Issue Published: 1 December 1930 PDF downloadLoading ...