tbuckley/cabot-search huggingface dataset:
Abstract 2539: Relationship of Aortic Wall Thickness and Distensibility with Subclinical Measures of Cardiovascular Disease: The Multi-Ethnic Study of Atherosclerosis
Authors: Hossein Bahrami, Joao A Lima, Joseph F Polak, Gregory D Pearson, Kiang Liu, David A Bluemke
Journal: Circulation (2007)

Background: While increased carotid intima-media thickness (IMT) is considered an independent risk factor for cardiovascular disease (CVD), little is known about the relationship of aortic thickness (AWT) and aortic distensibility (AD) with CVD risk factors. We studied the association of these aortic parameters with other measures of subclinical CVD. Methods: The Multi-Ethnic Study of Atherosclerosis (MESA) includes 6,814 participants, aged 45– 85 years; white, African-American, Hispanic, and Chinese. AD and AWT were measured by MRI. Average and maximum AWT of the proximal descending thoracic aorta were used as two measures of AWT. AD was calculated as the difference in aortic cross-sectional area indexed by diastolic cross-sectional area and average pulse pressure. IMT of the common and internal carotid arteries were determined by high-resolution B-mode ultrasonography and LV mass was determined by MRI. Phantom-adjusted Agatston calcium score from CT images was used to define coronary artery calcification (CAC). Results: In univariable analyses, higher carotid IMT, ankle-brachial index (ABI) &lt;0.9, CAC score, LV mass, and presence of coronary calcium were associated with lower AD and higher AWT (table ). However, in multivariable analyses, the only measures of subclinical CVD that had significant associations with both AD and AWT were LV mass and carotid IMT, while ABI was associated with only AWT. After adding age to the models, CAC score was no longer associated with either AD or AWT. The relationship between CAC score and AD varied by ethnicity; higher CAC score was associated with higher AD only in African Americans. Conclusions: AD and AWT are related to carotid IMT and LV mass, even after controlling for traditional risk factors. The associations of AD and AWT with CAC appears to be mainly due to their relationship with conventional risk factors, particularly age. Overall, AWT and AD may have closer relationship with LV mass than with subclinical atherosclerosis.
GATA3 haploinsufficiency does not block allergic sensitization or atopic disease
Authors: Monica G Lawrence, Jennifer W Leiding, Jonathan J Lyons, Amy P Hsu, Celeste C Nelson, Nina Jones, Alan Fitzgerald, Wade W Chien, Lisa Workman, Thomas A Platts-Mills, Carmen Brewer, Rachel I Gafni, Kelly D Stone, Joshua D Milner, Steven M Holland
Journal: Journal of Allergy and Clinical Immunology (2015)
Clinical Outcomes for Peripartum Cardiomyopathy in North America
Authors: Dennis M. McNamara, Uri Elkayam, Rami Alharethi, Julie Damp, Eileen Hsich, Gregory Ewald, Kalgi Modi, Jeffrey D. Alexis, Gautam V. Ramani, Marc J. Semigran, Jennifer Haythe, David W. Markham, Josef Marek, John Gorcsan, Wen-Chi Wu, Yan Lin, Indrani Halder, Jessica Pisarcik, Leslie T. Cooper, James D. Fett
Journal: Journal of the American College of Cardiology (2015)
Abstract 2846: Pulsed and Tissue Doppler Indices of Left Atrial Pressure Revisited: Doppler-Catheterization Correlative Studies Demonstrate Their Futility in Advanced Heart Failure Patients
Authors: Antonietta Evangelista, Maria Chiara Scali, Jayanta Mukherjee, Linda Ordway, Concetta Torromeo, Carlo Gaudio, Stefano DeCastro, H. Joachim Nesser, David DeNofrio, Jeffrey T Kuvin, Ayan R Patel, Natesa G Pandian
Journal: Circulation (2008)

Pulsed and tissue Doppler indices such as mitral flow E/A ratio (E/A), deceleration time (DT), ratio of mitral flow E wave to mitral annular E’ velocities (E/E’), and pulmonary vein systolic to diastolic flow velocity ratio (S/D ratio) have been considered to be indicators of left ventricular diastolic function and filling pressures. The reliability of these indices for gauging LA pressure (pulmonary capillary wedge pressure) in advanced heart failure (HF) patients has not been well studied. The aim of our investigation was to assess the accuracy of these parameters in hospitalized HF patients, in whom information about cardiac filling pressures is clinically important. We measured these indices prospectively in 28 patients hospitalized with HF and LV dysfunction, simultaneously or close to the time of pulmonary capillary wedge pressure (PCWP) measurement by cardiac catheterization and studied their correlation. Results: The left ventricular ejection fraction was 25±16%, and mean PCWP was 22±7 mmHg (range...
A novel dual ligand for peroxisome proliferator-activated receptor alpha and gamma (PPAR alpha/gamma), TZD 18, inhibits growth and induces apoptosis of human glioblastoma cell lines
Authors: Dachuan Liu, Hongyu Liu, Shunnan Xu, Martin H. Fenner, Kurt Possinger, Elena Elstner
Journal: Cancer Research (2004)

3860  Human glioblastoma are highly aggressive tumors characterized by a rapid proliferation rate, invasiveness, and angiogenesis. Over the decades, no effective therapeutic approaches are available in spite of advances in surgical techniques, radiotherapy, and chemotherapy; patient survival ranges from 9 to 12 months after initial diagnosis. The limited therapeutic possibilities for therapy of glioblastoma provide strong stimuli for exploring new approaches. The purpose of this study was to examine the effect of a novel dual ligand specific for PPAR alpha/gamma (TZD18, MERCK, NJ, USA) on the growth and apoptosis of human glioblastoma cell lines in vitro. The effect of TZD18 on the growth and apoptosis of two human glioblastoma cell line lines (T98G and DBTRG05MG) was assessed by MTT and cell death ELISA. Expression of cell-cycle and apoptotic-related proteins was measured by Western blotting. TZD18 significantly inhibited the growth of these cell lines in a dose- and time-dependent fashion associated with cell cycle arrest in G0/G1. Western blotting indicated that expression of cell cycle regulator p27kip1 was upregulated by TZD18 suggesting this protein may be involved in this process. Furthermore, a significant apoptosis was induced after treatment with TZD18 in both cell lines. Strong upregulation of pro-apoptotic proteins such as bax and p53 and downregulation of anti-apoptotic protein bcl-2 were noted, indicating that alteration of these protein levels may account for the observed apoptosis induced by TZD18. These results, for first time, demonstrated that TZD18 inhibits cell growth and induces apoptosis in human glioblastoma cell lines, suggesting a potential role for TZD18 in treatment of this malignancy. (This study was supported by grants from DFG und NGFN).
Abstract 128: Does Extracorporeal Cardiopulmonary Resuscitation Improve the Short- and Long-Term Outcome of Out-of Hospital Cardiac Arrest? Study of Advanced Life Support for Ventricular Fibrillation with Extracorporeal Circulation in Japan (SAVE-J)
Authors: Tetsuya Sakamoto, Yasufumi Asai, Ken Nagao, Hiroyuki Yokota, Naoto Morimura, Yoshio Tahara, Takahiro Atsumi, Mamoru Hase, Satoshi Nara
Journal: Circulation (2012)
Effect of Endurance Exercise Training on Endothelial Function and Arterial Stiffness in Older Patients With Heart Failure and Preserved Ejection Fraction
Authors: Dalane W. Kitzman, Peter H. Brubaker, David M. Herrington, Timothy M. Morgan, Kathryn P. Stewart, W. Gregory Hundley, Abdelhamed Abdelhamed, Mark J. Haykowsky
Journal: Journal of the American College of Cardiology (2013)
Variance of SUVs for FDG-PET/CT is Greater in Clinical Practice Than Under Ideal Study Settings
Authors: Virendra Kumar, Kavindra Nath, Claudia G. Berman, Jongphil Kim, Tawee Tanvetyanon, Alberto A. Chiappori, Robert A. Gatenby, Robert J. Gillies, Edward A. Eikman
Journal: Clinical Nuclear Medicine (2013)

Purpose Measurement variance affects the clinical effectiveness of PET-based measurement as a semiquantitative imaging biomarker for cancer response in individual patients and for planning clinical trials. In this study, we measured test-retest reproducibility of SUV measurements under clinical practice conditions and recorded recognized deviations from protocol compliance. Methods Instrument performance calibration, display, and analyses conformed to manufacture recommendations. Baseline clinical 18F-FDG PET/CT examinations were performed and then repeated at 1 to 7 days. Intended scan initiation uptake period was to repeat the examinations at the same time for each study after injection of 12 mCi FDG tracer. Avidity of uptake was measured in 62 tumors in 21 patients as SUV for maximum voxel (SUVmax) and for a mean of sampled tumor voxels (SUVmean). Results The range of SUVmax and SUVmean was 1.07 to 21.47 and 0.91 to 14.69, respectively. Intraclass correlation coefficient between log of SUVmax and log of SUVmean was 0.93 (95% confidence interval [CI], 0.88–0.95) and 0.92 (95% CI, 0.87–0.95), respectively. Correlation analysis failed to show an effect on uptake period variation on SUV measurements between the 2 examinations, suggesting additional sources of noise. The threshold criteria for relative difference from baseline for the 95% CI were ±49% or ±44% for SUVmax or SUVmean, respectively. Conclusions Variance of SUV for FDG-PET/CT in current clinical practice in a single institution was greater than expected when compared with benchmarks reported under stringent efficacy study settings. Under comparable clinical practice conditions, interpretation of changes in tumor avidity in individuals and assumptions in planning clinical trials may be affected.
Psychological Factors in Recovery from Myocardial Infarction: Preliminary Communication
Authors: J Kincey, E Geoffrey Wade
Journal: Journal of the Royal Society of Medicine (1984)

A small consecutive series of 27 myocardial infarction patients were interviewed at approximately 10 and 40 weeks after infarction to obtain data concerning the psychological aspects of rehabilitation. The results emphasized the need for consistency in imparting information and advice, and suggested the value of joint cardiological and clinical psychological assessment where patients fail to make expected progress. They pointed to a simple framework for intervention which is capable of further development and evaluation.
CLEANING AND DISINFECTION OF EQUIPMENT FOR GASTROINTESTINAL FLEXIBLE ENDOSCOPY - INTERIM RECOMMENDATIONS OF A WORKING PARTY OF THE BRITISH-SOCIETY-OF-GASTROENTEROLOGY - REPLY
Authors: Ivd Weller, Cb Williams, Dj Jeffries, Bg Gazzard, Atr Axon, Pjv Hanson, G Ayliffe, Ig Barrison, C Neumann
Journal: Gut (1988)
Abstract 2274: Remote Ischemic Preconditioning Using Transient Arm Ischemia Reduces Myocardial Injury During Cardiac Surgery
Authors: Derek J Hausenloy, Peter K Mwamure, Vinod Venugopal, Joanne Harris, Raymond J MacAllister, Matthew Barnard, Ernie Grundy, Elizabeth Ashley, Shyam Kolvekar, Martin Hayward, Bruce Keogh, Derek M Yellon
Journal: Circulation (2007)

Remote ischaemic preconditioning (RIPC) describes the phenomenon in which brief ischemia of one tissue or organ protects remote organs from a sustained episode of ischemia. Studies suggest that myocardial injury sustained during coronary artery bypass graft (CABG) surgery is associated with worse clinical outcomes. We conducted a single-blinded randomized controlled ‘proof-of-concept’ study to determine whether RIPC, using transient upper limb ischemia as the protective stimulus, reduces myocardial injury in patients undergoing CABG surgery. Fifty seven adult patients undergoing elective CABG surgery were randomized to RIPC (n=27) or control (n=30) following induction of anesthesia. RIPC comprised three 5-min cycles of right upper limb ischemia, induced by an automated cuff-inflator placed on the upper arm and inflated to 200 mmHg, with an intervening 5 minutes of reperfusion during which time the cuff was deflated. Serum troponin-T was measured pre-operatively and at 6, 12, 24, 48 and 72 hours post-surgery. Pre-operative troponin-T in all patients was &lt;0.01 μg/L. RIPC significantly reduced serum troponin-T release in patients undergoing elective CABG surgery, at 6, 12, 24 and 48 hours post-surgery, such that the total area under the curve was reduced by 43% with RIPC (20.58±9.58 μg/L over 72 hours in RIPC vs 36.12±26.08 μg/L over 72 hours in control: 95% CI 4.88–26.21 μg/L:P=0.005). This clinical study demonstrates for the first time that remote ischemic preconditioning induced by transient upper limb ischemia reduces myocardial injury in adult patients undergoing elective CABG surgery.
Purchasing vascular services
Authors: F G R Fowkes, M Forsythe
Journal: BMJ (1994)

prise, research into outcomes is still evolving; we believe that it will benefit from constructive criticism and debate on both sides of the Atlantic.Our external review of patient outcomes research teams in February 1993 led us to streamline the programme, moving more directly to hypothesis testing and telescoping the efforts to describe existing practice pattems and the state of the evidence.This new approach was reflected in a June 1993 research solicitation by the Agency for Health Care Policy and Research that signals a programme more heavily focused on hypothesis testing.This change is in emphasis, not in concept, for there will always be a need to understand existing practice pattems and to develop outcomes measures before experimental studies can be designed and mounted.We are not choosing between randomised controlled trials and all other methods; rather we are encouraging the efficient application of the appropriate methods to identify critical hypotheses and then test them.
Abstract 3710: Estrogen Does not Account for Accelerated Atherosclerosis in LDLr−/− Mice
Authors: Victoria L King, Nicholas Hatch, Xuan Zhang, Lisa R Tannock
Journal: Circulation (2008)

Clinical studies demonstrate less atherosclerosis in pre-menopausal women compared to age-matched men, but an equalization in atherosclerosis burden and cardiovascular event rates between genders following menopause. Conversely, using the LDLR−/− mouse model we and others have previously demonstrated that young female mice develop accelerated atherosclerosis compared to age matched males. Whether this difference is due to sex hormones or differences in metabolic factors is not clear. To determine if estrogen mediated the alterations in atherosclerosis in the female mice, female mice were ovariectomized (Ovx). Ovx mice had a marked reduction in uterus weight (Sham: 86 ± 1 vs Ovx: 26 ± 1mg, P &lt; 0.001) and both Ovx females and males had greater body weight gain when fed a lard-enriched diet (10% kcal from fat, D12451 , Research Diets) for 17 weeks compared to sham females. Ovariectomy resulted in an increase in fasting glucose concentrations, which was comparable to males. Cholesterol and triglyceride concentrations were higher in both sham and Ovx females compared to males; primarily distributed in increased VLDL and LDL particles. Interestingly, ovariectomy had no significant effect on extent of atherosclerotic lesion formation in female mice and the extent of atherosclerotic lesion area in both female groups was significantly increased compared to male mice. These data suggest that gender specific differences in lipids and atherosclerotic lesion formation in female LDL-R deficient mice fed a diet enriched in lard are not mediated by estrogen.
Abstract 2233: Comparison of Anatomical and Dynamic CT-derived Parameters between Scar, Border Zone and Healthy Myocardium in Patients Undergoing Ischemic VT Ablation
Authors: Jing Tian, Mark F Smith, Aharon Turgeman, Aharon Abbo, Patricia Bruce, Robert Hood, Robert Peters, Magdi Saba, Stephen Shorofsky, Timm M Dickfeld
Journal: Circulation (2008)

Background: Image integration in commerically available 3D mapping systems is currently only used for surface reconstruction of the blood pool/endocardial interface and does not provide any additional information about the myocardial scar substrate. Anatomic and dynamic data is available from high-resolution CT scans that could potentially identify scar and border zone and facilitate ventricular tachycardia ablations. Methods: Ten patients with ischemic cardiomypathy underwent contrast-enhanced cardiac CT prior to VT ablation. End-systole wall thickness (ESWT), end-diastole wall thickness (EDWS), wall thickening (WT) and wall motion (WM) were extracted from phase-specific, high-resolution CT. Using a 17 segment model CT criteria were compared with endocardial voltages using the standard clinical criteria of normal (&lt;1.5mV) or abnormal myocardium (&lt;1.5mV) as well as scar (&lt;0.5mV) and border zone (0.5–1.5mV). As proof-of-concept, endo/epicardial surfaces were reconstructed from the CT datasets and co-registered in a 3D mapping system to guide intra-procedural voltage mapping. Results: 50% of segments were homogenous, containing only voltages of one of the predefined voltage groups, and used for further analysis (26 abnormal/34 normal segments). EDWT, ESWT, WT and WM were 5.8±0.4mm, 5.7±0.6mm, 0±4% and 1.0±0.3mm for abnormal and 8.1±0.5mm, 10.9±0.7mm, 35.7±6.6% and 2.7±0.6mm for healthy segments, respectively. All four parameters differed significantly (P&lt;0.05) between healthy and abnormal segments. In subgroup analyses, EDWT, ESWT, WT and WM were 6.8±1.4mm, 7.0±2.1, 0±14% and 1.3±1.1mm for scar and 4.0±1.0m, 3.7±1.2mm, 0±11%mm and 0.0±0.0mm for border zone segments. All parameters differed significantly between scar and healthy (P&lt;0.05), border zone and healthy (P&lt;0.05) segments respectively. Registration of endo/epicardial surfaces allowed the intraprocedural assessment of wall thickness and correctly predicted areas of abnormal endocardial voltage. Conclusions: CT derived anatomic and dynamic parameters showed significant differences between voltage-defined normal and abnormal myocardium. Representation of such parameters such as wall thickness may facilitate the intraprocedural substrate characterization.
Abstract 5247: MiR-132 Regulates Angiotensin II Type 1 Receptor Expression Through a Protein Coding Region Binding Site
Authors: Terry S Elton, Donald E Kuhn, Geraldine E Malana, Mickey M Martin, Gerard J Nuovo, Adam P Pleister, David S Feldman
Journal: Circulation (2008)

Most of the known physiological and pathophysiological effects of angiotensin II (Ang II) are mediated via the angiotensin II type 1 receptor (AT1R). A number of studies suggest that AT1R expression levels are predominantly regulated by post-transcriptional mechanisms. Recently, it has been suggested that 30% of human genes may be regulated, by a novel post-transcriptional mechanism involving microRNAs (miRNAs). MiRNAs are natural, single-stranded, small RNA molecules that regulate gene expression by binding to target mRNAs and suppressing its translation or initiating its degradation. Our previous studies demonstrated that miR-155 can bind to the 3′-untranslated region (3′-UTR) of human AT1R mRNAs and translationally repress the expression of this protein. In this study, we demonstrate, for the first time, that miRNAs can also bind to sequence recognition sites harbored in the coding region of the human AT1R mRNA and suppress its translation. Specifically, i n situ hybridization experiments demonstrate that, like the AT1R, miR-132 is abundantly expressed in vascular smooth muscle cells (VSMCs) in vivo . Further, we show that over-expression of miR-132 (“gain-of function”) represses human AT1R expression in VSMCs. In contrast, “loss-of-function” experiments demonstrate that transfection of the miR-132 antisense inhibitor results in augmented AT1R protein levels. Importantly, miR-132 regulation of AT1R expression was abolished by mutating the putative miR-132 target site harbored in the AT1R mRNA open reading frame. Taken together, our study demonstrates that the AT1R and miR-132 are co-expressed and that miR-132 translationally represses the expression of AT1R in vivo . Our data support the hypothesis that Ang II responsiveness is “fine-tuned” by exquisitely regulating the expression levels of the AT1R by a number of distinct mechanisms including miRNA regulation.
Trk inhibitors provide better efficacy than a VEGF-R kinase inhibitor in combination with gemcitabine on improving survival in an orthotopic model of human PDAC
Authors: Susan E. Jones-Bolin, Kathryn Hunter, Hugh Zhao, Andres Klein-Szanto, Bruce Ruggeri
Journal: Cancer Research (2005)

3026   Background: CEP-701 and CEP-4416, pan-Trk kinase inhibitors (IC50 3.7 and 13 nM, respectively) with VEGFR-2 inhibitory activity (IC50 65 and 88 nM, respectively) (Current Medicinal Chemistry, 6: 845-57, 1999). CEP-7055 is a potent pan-VEGF-R kinase inhibitor lacking Trk inhibitory activity (Cancer Res, 63: 5978-91, 2003). Both CEP-701 and CEP-7055 are in clinical trials in cancer patients. The effects of these compounds, alone or in combination with gemcitabine (GMZ), on survival and primary/metastatic tumor dissemination were evaluated in an orthotopic model of human pancreatic ductal adenocarcinoma (PDAC) in athymic nude mice. Methods: Seven days post-surgical implantation, survival studies were performed. Study A had the following groups: Vehicle, CEP-701 monotherapy (10 mg/kg, SQ), GMZ monotherapy (100 mg/kg, IP, 3 times/week), CEP-701 plus GMZ, and Untreated. Study B: Vehicle, CEP-4416 monotherapy (20 mg/kg, PO), GMZ monotherapy, CEP-4416 plus GMZ, and Untreated. Study C: Vehicle, CEP-7055 monotherapy (23.8 mg/kg, PO), GMZ monotherapy, CEP-7055 plus GMZ, and Untreated. In addition, a study was performed to assess the efficacy of oral dosing with CEP-7055 or vehicle alone on metastatic spread for a total of 60 days or until animals were moribund. Mice were weighed and palpated twice weekly and remained on study unless they died or were sacrificed. Mice were removed from the survival studies if they became moribund (body weight decrease ≥ 15%, marked hunching and/or lethargy, severe ascites and jaundice). Results/Conclusions: CEP-7055 administration over the 60 day study resulted in a significant reduction in primary pancreatic tumor mass (p
A 40-Microrna Signature Characterizes JAK2V617F-Negative Essential Thrombocythemia: Role Of Mir-221 and Mir-203 In The Regulation Of The JAK-STAT Pathway
Authors: Alfons Navarro, Silvia Pairet, Aina Pons, Gerardo Ferrer, Raquel Longarón, Alberto Alvarez-Larrán, Luz Martínez-Avilés, Concepcion Fernández-Rodríguez, Mariano Monzó, Carlos Besses, Beatriz Bellosillo
Journal: Blood (2013)