Aflatoxin—Human Colon Carcinogenesis?
Authors: GRANT E. DEGER
Journal: Annals of Internal Medicine (1976)

Letters1 August 1976Aflatoxin—Human Colon Carcinogenesis?GRANT E. DEGER, M.D.GRANT E. DEGER, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-85-2-204 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptAflatoxins are toxic mold metabolites of Aspergillus flavus, a common and widely distributed food spoilage fungus. Aflatoxins have been identified in grains, coconuts, maze, oil seeds, and peanut meal. Humans ingesting stored moldy grain and nuts contaminated with aflatoxins characteristically develop liver damage: cholestasis, necrosis, bile duct proliferation, and even hepatomas (1). Furthermore, animals fed aflatoxins develop malignant neoplasms of multiple diverse organs including the colon (2). Aflatoxins apparently bind with DNA and translate this affinity into subsequently altered RNA and messenger protein (3).Colon carcinoma developed in two men who had worked with purified aflatoxin. While a cause and...References1. EDITORIAL: More on the aflatoxin-hepatoma story. Br Med J 2:547-548, 1975 CrossrefGoogle Scholar2. NEWBERNE P and ROGERS A: Rat colon carcinomas associated with aflatoxin and marginal vitamin A. J Natl Cancer Inst 50:439-448, 1973 CrossrefMedlineGoogle Scholar3. ELMUND G, BREWSTER T, and TU A: Aflatoxins—potent food poisons and carcinogenic compounds. J Chem Educ 49:398-399, 1972 CrossrefMedlineGoogle Scholar4. ASAO T, BUCH G, and ABDEL-KADER M: Aflatoxins B and G. J Am Chem Soc 85:1706-1707, 1963 CrossrefGoogle Scholar5. ASAO T, BUCH G, and ABDEL-KADER M: The structures of aflatoxins B and G. J Am Chem Soc 87:883-886, 1965 CrossrefGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: GRANT E. DEGER, M.D.Affiliations: 1800 C Street Bellingham, WA 98225 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byHost-mycobiome metabolic interactions in health and diseaseMycotoxins in Asia: is China in danger?Employing volcanic tuff minerals in interior architecture design to reduce microbial contaminants and airborne fungal carcinogens of indoor environmentsAn overview of mycotoxin contamination in foods and its implications for human healthMicotossineInvestigation of acute effects of aflatoxin on rat proximal and distal colon spontaneous contractionsAspergillus SectionFlavi and aflatoxins in dusts generated by agricultural processing facilities in the PhilippinesMycotoxinsMycotoxinsExperimental models of colorectal cancerMycotoxinsAirborne Aflatoxin in the Grain Processing Industries in IndiaAflatoxin B1Activation in Human LungMycotoxinsBioaerosols and occupational lung diseaseArticles activation of promutagens in a human bronchial epithelial cell line stably expressing human cytochrome P450 1A2Nonhepatic Disposition and Effects of Aflatoxin B1Perspectives on aflatoxin control for human food and animal feedA review of mycotoxins in indoor airMycotoxinsAflatoxins in Animal and Human HealthOther Proved and Suspected Foodborne Agents: Mycotoxins, Viruses, Aeromonas, Plesiomonas, Scombroid, and Paralytic Shellfish PoisoningsImmunological Responses to Aflatoxins and Other Chemical CarcinogensHealth Impact of Mycotoxins in the Home and Workplace: An OverviewExposure to Aflatoxins in DenmarkSpices and Mycotoxins—a Review of Biodeterioration and Health ImplicationsStructure–Activity RelationshipsCharacterization of the aflatoxin B1-binding site of rat albuminCrop storage losses in southern Nigeria caused by the activities of micro-organismsAfaltoxin B1 transport in rat blood plasma. Binding to albumin in vivo and in vitro and spectrofluorimetric studies into the nature of the interactionAflatoxin B1 alters protein phosphorylation in rat liversPenetration of aflatoxins through isolated human epidermisAN ASSESSMENT OF AFLATOXIN B 1 IN THE ENVIRONMENT OF A RICE GROWING COMMUNITY AND ASSOCIATED CANCER RISKAflatoxin exposures in the industrial setting: An epidemiological study of mortalityAflatoxin in respirable airborne peanut dustThin layer chromatographic analysis of possible aflatoxins within grain dustsGenetic Toxicology of Some Known or Suspected Human CarcinogensGenetic Bioassay Data on Some Known or Suspected Human CarcinogensNew Perspectives on Aflatoxin BiosynthesisAssociation of aflatoxin B1 with plasma components in vitroStudies on the Effects of Single Fiber Sources in the Dimethylhydrazine Rodent Model of Human Bowel NeoplasiaBiological Characteristics of the Aflatoxin-Induced Hepatic TumorCarcinogen Metabolism in Human Tissues and CellsAflatoxin in respirable corn dust particlesMetabolism of aflatoxin B1, benzo[a]pyrene, and 1,2-dimethylhydrazine by cultured rat and human colonAMNIOTIC ADHESIONMALFORMATIONSATTEMPTED SUICIDE WITH PURIFIED AFLATOXINThe role of nutrition in the etiology and prevention of cancerSuppression of Phytohemagglutinin Response by Fungi from a “Leukemia” HouseSensitivity differences displayed by drosophila melanogaster larvae of different ages to the toxic effects of growth on media containing aflatoxin B1Reduced aflatoxin toxicity in hybrid crosses of aflatoxin B1 sensitive and resistant strains of Drosophila melanogaster (Diptera)Experimental Intestinal Cancer Research with Special Reference to Human PathologyExperimental colon cancerNotes on mycotoxins as natural and occupational hazards of man 1 August 1976Volume 85, Issue 2Page: 204-205KeywordsCarcinogenesisColonDNAFoodHepatocellular carcinomaLiverMetabolitesNecrosisOilsRNA ePublished: 1 December 2008 Issue Published: 1 August 1976 PDF downloadLoading ...