tbuckley/cabot-search huggingface dataset:
AIDS in Asia
Authors: Roger Detels
Journal: JAMA (2005)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Females with FVIII and FIX deficiency have reduced joint range of motion
Authors: Robert F. Sidonio, Fatima D. Mili, Tengguo Li, Connie H. Miller, William C. Hooper, Michael R. DeBaun, Michael Soucie
Journal: American Journal of Hematology (2014)

Little is known about rates of joint bleeding among females with FVIII/FIX deficiency or hemophilia carriers. In a cross-sectional study, we tested the hypothesis that females with FVIII or FIX deficiency enrolled in the Universal Data Collection (UDC) project had a reduced mean overall joint range of motion (ROM) compared with historic controls from the Normal Joint Study. Demographics, clinical characteristics, and joint ROM measurements on 303 females without a bleeding disorder and 148 females with FVIII and FIX deficiency, respectively, between the ages of 2-69 years and a body mass index (BMI) ≤ 35 were compared. Multivariate linear regression was performed with the overall joint ROM (sum of the right and left ROM measurements of five joints) as the dependent variable and FVIII or FIX activity as the independent variable adjusting for age, race, BMI, and number of joint bleeds reported over the last 6 months. As FVIII and FIX activity decreased, the mean overall joint ROM became reduced and in most cases was significantly lower than that of the controls regardless of age and clinical hemophilia severity. Further investigation of reduced joint ROM as evidence of subclinical joint bleeding in females with FVIII and FIX deficiency is warranted.
Protein Kinase C Inhibition and X-Linked Inhibitor of Apoptosis Protein Degradation Contribute to the Sensitization Effect of Luteolin on Tumor Necrosis Factor–Related Apoptosis-Inducing Ligand–Induced Apoptosis in Cancer Cells
Authors: Ran-Xin Shi, Choon-Nam Ong, Han-Ming Shen
Journal: Cancer Research (2005)

Abstract Tumor necrosis factor (TNF)–related apoptosis-inducing ligand (TRAIL) is an important member of the TNF superfamily with great potential in cancer therapy. Luteolin is a dietary flavonoid commonly found in some medicinal plants. Here we found that pretreatment with a noncytotoxic concentration of luteolin significantly sensitized TRAIL-induced apoptosis in both TRAIL-sensitive (HeLa) and TRAIL-resistant cancer cells (CNE1, HT29, and HepG2). Such sensitization is achieved through enhanced caspase-8 activation and caspase-3 maturation. Further, the protein level of X-linked inhibitor of apoptosis protein (XIAP) was markedly reduced in cells treated with luteolin and TRAIL, and ectopic expression of XIAP protected against cell death induced by luteolin and TRAIL, showing that luteolin sensitizes TRAIL-induced apoptosis through down-regulation of XIAP. In search of the molecular mechanism responsible for XIAP down-regulation, we found that luteolin and TRAIL promoted XIAP ubiquitination and proteasomal degradation. Next, we showed that protein kinase C (PKC) activation prevented cell death induced by luteolin and TRAIL via suppression of XIAP down-regulation. Moreover, luteolin inhibited PKC activity, and bisindolylmaleimide I, a general PKC inhibitor, simulated luteolin in sensitizing TRAIL-induced apoptosis. Taken together, these results present a novel anticancer effect of luteolin and support its potential application in cancer therapy in combination with TRAIL. In addition, our data reveal a new function of PKC in cell death: PKC activation stabilizes XIAP and thus suppresses TRAIL-induced apoptosis.
Abstract 2826: Microvascular Obstruction on Cardiac MRI is Associated with an Early Peak Troponin
Authors: James C Weaver, David Rees, Ananth M Prasan, Jane A McCrohon
Journal: Circulation (2008)

Background : Microvascular obstruction (MVO) post STEMI, as defined on cardiac MRI (CMR), reflects slow flow in the microvasculature. It has been postulated that MVO may result in impaired washout of troponin (Tn) and therefore a later peak. Aim : To use CMR to explore the relationship between MVO and the pattern of TnI release after STEMI. Methods: After successful primary angioplasty serial TnI measurements were taken at 6, 14 and 24 hours. Gadolinium (Gd) enhanced CMR was performed at 4.7±2 days and again at 191±17 days. Infarction was defined as a hyperenhanced region 10 minutes after intravenous 0.1mmol/kg Gd and MVO defined as a hypoenhanced region in the centre of this infarcted segment. A 17 segment model was used for wall motion assessment and functional recovery. Results: 26 patients, age 57 ±11 yrs, were included in the analysis. On early scanning infarct size was 22.1±13% and MVO was 4.3± 4% of LV mass. The 81% of patients with MVO had an earlier peak TnI than those without MVO (p=0.005). Patients with severe MVO, defined as the highest quartile of MVO extent, all had the earliest peak of 6hrs. Those with MVO had higher TnI at 6hrs (p=0.002), 14hrs (p=0.027) and area under the curve (AUC) (p=0.014). TnI levels at all time points in the first 24 hours had a very strong correlation with MVO extent (r=0.80 – 0.88, p&lt;0.001). This was stronger than between TnI and infarct size (r=0.68 – 0.78, p&lt;0.001). Equally an early peak TnI (6hrs compared with 14hrs) was associated with a higher peak TnI level (p=0.013) and AUC (p=0.019). In the 17 patients with follow up scans infarct involution was 19.8±13% and the relationship between TnI level and infarct size did not change significantly. As MVO increased there was less functional recovery (r=−0.49, p=0.046) and increased left ventricular end diastolic volume (r=0.512, p=0.036) at 6 months. Of the 5 patients who developed dyskinetic segments 3 had severe MVO and 4 an early peak TnI. Conclusion: MVO presence and extent is associated with an early peak in TnI after reperfused STEMI and more extensive myonecrosis as evidenced by cumulative (AUC) TnI release. These findings favour more complete myonecrosis within the MVO region, rather than impaired washout, as the predominant pathological basis for the relationship between MVO and TnI kinetics.
THE IMPORTANCE TO THE INTERNIST OF LATENT PARANASAL SINUSITIS
Authors: George H. Lathrope, Lyndon A. Peer, Royce Paddock
Journal: Annals of Internal Medicine (1939)

Article1 April 1939THE IMPORTANCE TO THE INTERNIST OF LATENT PARANASAL SINUSITISGEORGE H. LATHROPE, M.D., F.A.C.P., LYNDON A. PEER, M.D., ROYCE PADDOCK, M.D.GEORGE H. LATHROPE, M.D., F.A.C.P.Search for more papers by this author, LYNDON A. PEER, M.D.Search for more papers by this author, ROYCE PADDOCK, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-12-10-1576 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptParanasal sinusitis in its focal infective aspect has received considerable and merited attention in the last 15 years. The acute and chronic suppurative conditions, with pain, febrile course, frontals or antra opaque on transillumination, pus pouring from ethmoid-sphenoid region or copious purulent washings from an antrum, are easily recognized, and, in general, well handled.Chronic hyperplastic sinusitis, on the other hand, is for the more part a milder condition whose usual manifestations are neither pronounced nor dramatic. The relationship of this lesion to asthma has been emphasized by Cooke.1We propose to discuss the part played by some of its...Bibliography1. COOKEGROVE RARC: Etiology and nature of hyperplastic sinusitis, Arch Otolaryng., 1933, xviii, 622. Google Scholar2. SNELL AM: Disease of the gall-bladder and bile duct, Oxford Medicine, Vol. III, part 1, page 448. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Newark, New Jersey*Received for publication March 8, 1938.Read before the American Clinical and Climatological Association, Baltimore, Oct. 12, 1937. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byAllergy in otorhinolaryngology and ophthalmology. A review of the recent current literature 1 April 1939Volume 12, Issue 10Page: 1576-1582KeywordsAsthmaLesions ePublished: 1 December 2008 Issue Published: 1 April 1939 PDF downloadLoading ...
Abstract 13743: Prognostic Values of Ratio of Serum Eicosapentaenoic Acid to Arachidonic Acid on Clinical Outcome after Endovascular Therapy in Patients with Peripheral Artery Disease due to Femoropopliteal Artery Lesions
Authors: Keiichi Hishikari, Shigeki Kimura, Yosuke Yamakami, Keisuke Kojima, Takatoshi Shigeta, Yuichiro Sagawa, Hirohumi Otani, Tomoyo Sugiyama, Taishi Kuwahara, Hiroyuki Hikita, Atsushi Takahashi, Mitsuaki Isobe
Journal: Circulation (2014)

Background: Peripheral artery disease (PAD) patients have a substantially increased risk of mortality and cardiovascular morbidity than those without PAD. However, risk prediction tools have not been established among patients with PAD to identify who is likely destined for adverse clinical outcome. Eicosapentaenoic acid to arachidonic acid (EPA/AA) ratio has emerged as predictor of mortality endpoints in vascular diseases, especially, coronary artery disease and cerebrovascular disease. In contrast, the prognostic value of EPA/AA ratios in patients with PAD is unclear. We sought to examine whether assessment of serum ratio of EPA/AA in patients with PAD due to femoropopliteal artery lesions can predict clinical outcome after endovascular therapy (EVT). Methods: We obtained serum EPA/AA ratio in 132 consecutive patients with PAD due to femoropopliteal artery lesions before EVT. We analyzed the incidence of major adverse event (MAE) including major adverse limb event (MALE) and any-cause death. The clinical characteristics and laboratory variables were compared and analyzed between MAE group and non-MAE group. Cox regression analyses were used for survival tests. Receiver operating characteristics (ROC) curve analysis was used to determine an optimal cutoff value for EPA/AA ratio to predict MAE after EVT. Results: At a median follow-up of 17 months, MALE occurred in 39 patients (29.5%) and 10 patients (7.6%) died. Significantly lower level of preprocedural serum EPA/AA ratio was observed in the MAE group than non-MAE group. Multivariable Cox analysis showed critical limb ischemia (hazard ratio, 2.93; 95% confidence interval [CI], 1.59-5.40; P = 0.001) and preprocedural serum EPA/AA ratio (hazard ratio, 0.08; 95% CI, 0.02-0.43; P = 0.003) were independent predictors of MAE after EVT. The cutoff value of EPA/AA ratio via ROC curve analysis was 0.29 (66.3% sensitivity, 73.5% specificity). Conclusions: Our findings suggest that lower serum EPA/AA ratio is associated with a greater risk of MALE and any-cause death after EVT in patients with PAD due to femoropopliteal artery lesions.
Asthma diagnosis by the reversibility test of respiratory muscles power in asthmatics using the respiratory pressure meter
Authors: Omer Elbadri, Mohamed Elbagir Ali, Aamir Magzoub, Omer Musa
Journal: European Respiratory Journal (2011)

Introduction: Intermittent and mild asthma types are difficult to diagnose during the symptoms free period. The respiratory muscles perform extra work in asthma and expected to be stronger than normal subjects. The respiratory pressure meter measures the respiratory muscle power as a function of the air volume expired or inspired by effort. The hypothesis introduced was that if the bronchioles are dilated by a bronchodilator the expired volume of air and consequently the pressure it exerts is expected to increase.

Objective: To perform a pilot reversibility test in asthmatic patients by spirometry and respiratory pressure meter.

Methods: This is a cross-sectional hospital based study carried out in Lung function tests clinic in Police hospital in Khartoum in 2010 -2011 to determine the reversibility of the respiratory muscle power after salbutamol inhalation using the respiratory pressure meter. Following informed consent, PEFR, FEV1/FVC, Maximum expiratory pressure (MEP) and Maximum inspiratory pressure (MIP) were measured in 20 patients with asthma and the tests were repeated 15 minutes after salbutamol inhalation. All patients were not during an acute attack.

Results: 20 patients were included. FEV1 reversibility was 10.8% and PEFR reversibility was 13.1%. The MEP increased from 81.2 cmH2 O to 91.2 cmH2O, with a reversibility of 12.3% while the MIP increased from 60.8 to 69.95 cm H2O, with a reversibility of 15%.

Conclusion: Respiratory muscles power reversibility could be a potentially sensitive diagnostic test for asthma.
Lipid derivatives of dopamine and respiration
Authors: Dominika Zajac, Agnieszka Stasinska, Mieczyslaw Pokorski
Journal: European Respiratory Journal (2014)

Lipid derivatives of dopamine are a new class of substances with dopamine-like activity and of potential use in the field of neurodegenerative disorders. However, the interaction of such compounds with the respiratory system remains unclear. The aim of the study was to examine how three main members of this class, N-oleoyl-dopamine (OLDA), 39-O-methyl-N-oleoyl-dopamine (OMeOLDA) and 39-O-oleoyl-N-oleoyl-dopamine (OLOLDA) would influence the hypoxic ventilator response (HVR) of the rat. The study was performed in 20 rats conscious rats. Ventilation and its responses to 8% O2 in N2 were measured in a whole body plethysmographic chamber. The findings were that OLDA decreased the peak hypoxic ventilatory response from 2279.0 ±237.8 to 1338.3 ±49.5 ml·min -1 ·kg -1 , OMeOLDA - from 1698.3 ±88.2 to 1433.8± 97.4 ml·min -1 ·kg -1 , and OLOLDA – from 1885.9 ±52.2 to 1530.4 ±56.3 ml·min -1 ·kg -1 ; the decreases amounted to 46, 16, and 25%, respectively (p
Colchicine for Prevention of Early Atrial Fibrillation Recurrence After Pulmonary Vein Isolation
Authors: Spyridon Deftereos, Georgios Giannopoulos, Charalambos Kossyvakis, Michael Efremidis, Vasiliki Panagopoulou, Andreas Kaoukis, Konstantinos Raisakis, Georgios Bouras, Christos Angelidis, Andreas Theodorakis, Metaxia Driva, Konstantinos Doudoumis, Vlasios Pyrgakis, Christodoulos Stefanadis
Journal: Journal of the American College of Cardiology (2012)
Abstract 12539: Physical Activity, Uric Acid and Risk of Hypertension
Authors: Lucio Mos, Francesca Saladini, Claudio Fania, Guido Garavelli, Maurizio Ruscio, Stefano Martina, Edoardo Casiglia, Paolo Palatini
Journal: Circulation (2014)

Introduction: The association of uric acid with risk of hypertension is controversial and may be modulated by other risk factors. We did a prospective study to investigate whether uric acid was an independent predictor of risk of hypertension in the young and whether an unhealthy lifestyle could favour this association. Design and methods: The study was conducted in a cohort of 1060 young to middle age subjects screened for stage 1 hypertension and followed for a median of 11 years. In multivariable Cox analyses, data were adjusted for age, gender, body mass index (BMI), parental hypertension, 24-hour systolic and diastolic blood pressure, serum creatinine, lifestyle factors and metabolic data. Results: At baseline uric acid showed an independent positive association with male gender, BMI, creatinine and metabolic data and a negative association with age and smoking. The uric acid level was 5.03 mg/dL in the sedentary subjects (n=659) and 5.00 mg/dL in the active subjects (p=n.s.). At follow-up end, 677 subjects developed hypertension needing treatment. In the whole group, uric acid was an independent predictor of future hypertension (p=0.004). Participants with uric acid &gt; 5.60 mg/dL (lower limit of the top tertile) had a 31% increase in risk compared to those of the bottom tertile. However, the risk of hypertension related to uric acid was increased only among the sedentary subjects (p=0.0017) with a hazard ratio of 1.43 (95%CI, 1.10-1.88) for the subjects of the top uric acid tertile compared to those of the bottom tertile. In contrast, among the active subjects no association was found between uric acid and risk of hypertension (p=0.56). The association between uric acid and future hypertension remained virtually unchanged when baseline serum glucose, cholesterol and triglycerides were included in the regression models. Conclusions: Uric acid is an independent predictor of hypertension in young to middle age subjects. However, regular physical activity prevents the development of hypertension related to hyperuricemia. These data suggest that exercise can counteract the pathophysiological mechanisms involved in the association between hyperuricemia and development of hypertension.
Care in the Community: Illusion or Reality?, by Ed Julian Leff
Authors: L. Lessof
Journal: BMJ (1997)

Ed Julian Leff: John Wiley, £14.99, pp 212 ISBN 0 471 96982 6

The closure of Friern and Claybury hospitals has been the subject of the “largest and most comprehensive evaluation” of the resettlement of psychiatric patients in the community. Professor Julian Leff has presided over the Team for the Assessment of Psychiatric Services (TAPS), which carried out the evaluation throughout its 11 years, and has now brought together 15 contributions that distil its results and implications. This book is thus not just another collection of essays …
Drug refusal: a study of psychiatric inpatients
Authors: P S Appelbaum, T G Gutheil
Journal: American Journal of Psychiatry (1980)

The authors studied patients' refusal of medication during a three-month period on an inpatient service of a community mental health center. Although refusal of medication was common, most episodes were self-limited. Only 5 of 72 episodes seriously impaired patient care; each of these cases appeared to be delusionally motivated. Legal conceptions of a right to refuse treatment may not accurately portray the realities of the clinical situation, in which patients' refusal is determined by the dynamics of their illness rather than reflecting a principled exercise of their legal rights.
NIH Defense Plan in the Works
Authors: Brian Vastag
Journal: JAMA (2002)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Nationwide Population Science
Authors: Ann W. Hsing, John P. A. Ioannidis
Journal: JAMA Internal Medicine (2015)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Internal Medicine HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Internal Medicine journal
Chrysin reduces the degree of lung injure which induced by lipopolysaccharides (LPS): Possible involvement of oxidative stress and the NF-κB pathway
Authors: Lian Liu, Xiao-Ou Li, Tao Wang, Ling-Li Guo, Fu-Qiang Wen
Journal: European Respiratory Journal (2014)

Objectives:  ALI is a diffuse heterogeneous lung injury characterized by hypoxemia, low lung compliance and widespread capillary leakage. The levels of oxidative stress and inflammation are very high in the lung tissue of the ALI patients. In this study, we investigated the effects of chrysin on oxidative stress and NF-κB pathway in the LPS-induced ALI model.   Methods:  BALB/c mice with or without LPS intratracheally injected were intraperitonealy injected with Chrysin (50,100,200mg/kg). IL-6 and TNF-α levels in BALF were determined by ELISA. Phospho-NF-κB p65, NF-κB p65, Phospho-IκBα and IκBα levels in mouse lungs tissue were evaluated by western blot. Malondialdehyde levels in mouse lungs were detected. HE staining for histology was performed.   Results:  BALF neutrophil counts,TNF-α and IL-6 levels were significantly increased in the LPS model group, but this upregulaion was attenuated by chrysin (p   Conclusions:  These results suggest that chrysin attenuated oxidative stress and the levels of Phospho-NF-κB p65 induced by LPS; the inflammation was also reduced by chrysin. Chrysin might have the function to protect lungs from the LPS-induced ALI through the regulation of oxidative stress and the NF-κB pathway.