tbuckley/cabot-search huggingface dataset:
Lymphocyte populations and cytokine concentrations in pericardial fluid from a systemic lupus erythematosus patient with cardiac tamponade
Authors: L. M VILA, J. R R. DEL RIO, L. M VILA, Z. RIOS, E. RIVERA
Journal: Annals of the Rheumatic Diseases (1999)

Pericardial involvement is the most common cardiovascular complication in systemic lupus erythematosus (SLE).1 The clinical picture varies from subclinical pericardial effusion and classic acute pericarditis to cardiac tamponade.1 2Immunological studies of pericardial fluid (PF) have been limited to determination of autoantibodies, complements and immune complexes.3 4 To further study the pathogenic mechanisms involved in lupus pericarditis we examined the lymphocytic populations and cytokine concentration pattern in PF and peripheral blood (PB) from a SLE patient with cardiac tamponade.

We report a case of a 38 year old man with SLE diagnosed in December 1995 when he presented with polyarthritis, photosensitivity, oral ulcers, nephritis, non-hemolytic anaemia, positive ANA, increase of anti-dsDNA and hypocomplementaemia. The patient improved with corticosteroid and intravenous …
Use of clomiphene and luteinizing hormone/follicle stimulating hormone-releasing hormone in investigation of ovulatory failure.
Authors: J Ginsburg, A J Isaacs, M B Gore, C W Havard
Journal: BMJ (1975)

A luteinizing hormone/follicle-stimulating hormone-releasing hormone (LH/FSH-RH) test was performed in 70 women with amenorrhoea or anovulatory infertility, or both, and a clomiphene stimulation test was also performed in 24 of these patients. Most patients responded to LH/FSH-RH with significant increases in LH and FSH. In women with gonadal dysgenesis or premature ovarian failure exaggerated responses were observed after LH/FSH-RH and there was no change in high basal LH levels after clomiphene. Patients with absent or impaired responses to LH/FSH-RH failed to respond to clomiphene. All patients with anovulatory menstrual cycles responded to both LH/FSH-RH and clomiphene, while seven out of 13 amenorrhoeic patients with a normal LH/FSH-RH response showed an early LH rise during clomiphene treatment and six were unresponsive. These results suggest a difference between the two groups at hypothalamic level with consequent therapeutic implications.
Induction or Augmentation of Labor and Autism
Authors: Michael L. Stitely
Journal: JAMA Pediatrics (2014)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Pediatrics HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Pediatrics journal
C-erbB-2 expression and codon 12 K-ras mutations both predict shortened survival for patients with pulmonary adenocarcinomas.
Authors: J A Kern, R J Slebos, B Top, S Rodenhuis, D Lager, R A Robinson, D Weiner, D A Schwartz
Journal: Journal of Clinical Investigation (1994)

We evaluated the prognostic significance of p185c-erbB-2 expression and ras gene mutations in all patients diagnosed with a pulmonary adenocarcinoma between 1982 and 1985 at the University of Iowa. p185c-erbB-2 expression was detected in 15 cases (34%). A ras gene mutation was found in 16 cases (36%) and all were in codon-12 of K-ras. No N-ras mutations were identified. Both p185c-erbB-2 expression and a K-ras mutation were found only in codon-12 and present in six cases (14%). By univariate analysis p185c-erbB-2 expression was associated with shortened survival (P = 0.02) while the presence of a K-ras mutation was not (P = 0.16). Multivariate analysis by the Cox proportional hazards model, controlling for patient age and tumor stage, also continued to identify p185c-erbB-2 expression as an independent unfavorable prognostic factor (P = 0.01). In this model a K-ras mutation also approached significance as a poor prognostic indicator (P = 0.06). The impact of both p185c-erbB-2 expression and a K-ras mutation on survival was additive and highly significant (P = 0.004). This additive nature suggests that together these two markers identify a high-risk population of lung adenocarcinoma patients that may benefit from aggressive therapy.
Nudge, Nudge or Shove, Shove—The Right Way for Nudges to Increase the Supply of Donated Cadaver Organs
Authors: Kyle Powys Whyte, Evan Selinger, Arthur L. Caplan, Jathan Sadowski
Journal: The American Journal of Bioethics (2012)

Richard Thaler and Cass Sunstein (2008) contend that mandated choice is the most practical nudge for increasing organ donation. We argue that they are wrong, and their mistake results from failing to appreciate how perceptions of meaning can influence people's responses to nudges. We favor a policy of default to donation that is subject to immediate family veto power, includes options for people to opt out (and be educated on how to do so), and emphasizes the role of organ procurement organizations and in-house transplant donation coordinators creating better environments for increasing the supply of organs and tissues obtained from cadavers. This policy will provide better opportunities for offering nudges in contexts where in-house coordinators work with families. We conclude by arguing that nudges can be introduced ethically and effectively into these contexts only if nudge designers collaborate with in-house coordinators and stakeholders.
Harold Walter Henry Shepperd
Authors: A. G. Kerr
Journal: BMJ (2015)

Harold Walter Henry Shepperd, a former head prefect of Campbell College, Belfast, set his sights on a surgical career while still a houseman. Having passed his primary FRCS, he went straight into otolaryngology, doing his training in the Royal Victoria Hospital, Belfast, and the Middlesex Hospital. Initially appointed in 1959 to a …
AAV8-mediated Hepatic Gene Transfer in Infant Rhesus Monkeys (Macaca mulatta)
Authors: Lili Wang, Peter Bell, Jianping Lin, Roberto Calcedo, Alice F Tarantal, James M Wilson
Journal: Molecular Therapy (2011)

Many genetic metabolic diseases manifest in infancy, therefore, it is important to develop effective treatments that could be implemented at this time. Adeno-associated virus serotype 8 (AAV8) gene transfer has been studied in neonatal mouse, cat, and dog models and shown some efficacy with a single hepatic injection at birth. AAV8-mediated liver gene transfer has also generated sustained therapeutic effects in feline and canine models of lysosomal storage disorders. In these models, delaying the age of vector treatment increased gene transfer stability. The growth rate of infant nonhuman primates is more similar to the growth trajectory of humans, thus infant monkeys provide an excellent model to study AAV gene transfer efficiency, stability, and safety. In this study, we report for the first time that AAV8-mediated hepatic gene transfer in infant monkeys is safe and efficient but less stable when compared to adolescent animals. Infant monkeys administered AAV8 intravenously at 1 week postnatal age achieved up to 98% transduction of hepatocytes within 7 days of injection; however, there was significant dilution of genomes and loss of transgene expression 35 days postadministration. Delaying the injection to 1 month postnatal age did not improve stability of transduction but decreased the antibody response to AAV8 capsid.
FRAGMENTED QRS: A PREDICTOR OF MYOCARDIAL FIBROSIS IN HYPERTROPHIC CARDIOMYOPATHY
Authors: Nabeel Sheikh, Michael Papadakis, Rachel Bastiaenen, Lynne Millar, Noel Emmanuel, Sabiha Gati, Abbas Zaidi, Saqib Ghani, Navin Chandra, Elijah Behr, Sanjay Sharma
Journal: Journal of the American College of Cardiology (2012)
Controversy on drugs affecting ATP sensitive potassium channel in ischaemic heart disease
Authors: I. Chi, S C Black, G S Friedrichs, B K Ll'cchesi
Journal: Cardiovascular Research (1994)

Journal Article Controversy on drugs affecting ATP sensitive potassium channel in ischaemic heart disease Get access I. Chi, I. Chi Department of Pharmacology, University of Michigan Medical School, Ann Arbor, MI 48 109, USA Search for other works by this author on: Oxford Academic PubMed Google Scholar S C Black, S C Black Department of Pharmacology, University of Michigan Medical School, Ann Arbor, MI 48 109, USA Search for other works by this author on: Oxford Academic PubMed Google Scholar G S Friedrichs, G S Friedrichs Department of Pharmacology, University of Michigan Medical School, Ann Arbor, MI 48 109, USA Search for other works by this author on: Oxford Academic PubMed Google Scholar B K Ll'cchesi B K Ll'cchesi Department of Pharmacology, University of Michigan Medical School, Ann Arbor, MI 48 109, USA Search for other works by this author on: Oxford Academic PubMed Google Scholar Cardiovascular Research, Volume 28, Issue 1, January 1994, Pages 136–137, https://doi.org/10.1093/cvr/28.1.136 Published: 01 January 1994
CCCTC-Binding Factor and the Transcription Factor T-bet Orchestrate T Helper 1 Cell-Specific Structure and Function at the Interferon-γ Locus
Authors: Masayuki Sekimata, Mercedes Pérez-Melgosa, Sara A. Miller, Amy S. Weinmann, Peter J. Sabo, Richard Sandstrom, Michael O. Dorschner, John A. Stamatoyannopoulos, Christopher B. Wilson
Journal: Immunity (2009)
Sassafras and Herb Tea
Authors: Alvin B. Segelman
Journal: JAMA (1976)

HOT WATER infusions (tea) prepared from the root bark of the sassafras tree (<i>Sassafras albidum</i>[Nut-tall] Nees [family Lauraceae]) have long been employed by the public as tonics as well as for a variety of unsubstantiated therapeutic purposes. Extensive studies conducted by the Food and Drug Administration (FDA) in 1960 showed that safrole (4-allyl-1,2-methylenedioxybenzene), the major chemical constituent (eg, up to 80% by weight) of the aromatic oil present in sassafras root bark, was a hepatocarcinogen in rats. As a result, an order published in the<i>Federal Register</i>of Dec 3,1960, prohibited the use of safrole in foods.<sup>1</sup>Prior to this regulation, safrole (up to 20 ppm) and safrole-containing sassafras extracts found wide use as flavoring agents especially in beverages such as root beer. Since that time, the hepatotoxic effects of safrole in animals have been reported and confirmed by numerous investigators.<sup>2</sup> To be considered unsafe and hence
Edward Barry Adams
Authors: O. Jolobe, Y. K. Seedat
Journal: BMJ (2011)

Edward Barry Adams (“Barry”), emeritus professor of medicine at the Nelson R Mandela Medical School of the University of Natal, Durban, was a highly esteemed clinician and teacher best remembered for instilling in his students an enduring recognition that acquisition of skills in eliciting and interpreting signs and symptoms was fundamental to good clinical practice. He began his postgraduate training at Oxford University. The subject of his interest at Oxford was aplastic anaemia.

Although his declared interest was haematology, characterised by seminal publications on iron deficiency, megaloblastic anaemia, and protein deficiency, he was equally at home exercising his …
Potent antitumor effects of bevacizumab in a microenvironment-dependent human lymphoma mouse model
Authors: F Mori, T Ishida, A Ito, F Sato, A Masaki, H Takino, M Ri, S Kusumoto, H Komatsu, R Ueda, H Inagaki, S Iida
Journal: Blood Cancer Journal (2012)

We established a mouse model of microenvironment-dependent human lymphoma, and assessed the therapeutic potential of bevacizumab, an antitumor agent acting on the microenvironment. NOD/Shi-scid, IL-2Rγnull (NOG) mice were used as recipients of primary tumor cells from a patient with diffuse large B-cell lymphoma (DLBCL), which engraft and proliferate in a microenvironment-dependent manner. The lymphoma cells could be serially transplanted in NOG mice, but could not be maintained in in vitro cultures. Injection of bevacizumab together with CHOP (cyclophosphamide, doxorubicin, vincristine, prednisolone) significantly increased necrosis and decreased vascularization in the tumor, compared with CHOP alone. Levels of human soluble interleukin-2 receptor (sIL2R) in the serum of bevacizumab+CHOP-treated mice (reflecting the DLBCL tumor burden) were significantly lower than in CHOP recipients. Mice receiving bevacizumab monotherapy also showed significant benefit in terms of tumor necrosis and vascularization, as well as decreased serum sIL2R concentrations. The present DLBCL model reflects the human DLBCL in vivo environment more appropriately than current mouse models using established tumor cell lines. This is the first report to evaluate the efficacy of bevacizumab in such a tumor microenvironment-dependent model. Bevacizumab may be a potential treatment strategy for DLBCL patients.
At the retreat
Authors: Daniel M. Becker
Journal: JAMA (2008)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Principles of Epidemiology
Authors: Fred B. Rogers
Journal: JAMA (1965)

A second edition of this text, initially published in 1957, is welcome. The book is by two wellknown English epidemiologists; the senior author is Principal Medical Officer, London County Council, and the junior author is Professor of Preventive Medicine and Public Health, University of Sheffield. The authors stated their aims in the preface to first edition: "Our purpose in writing this book has been to present the main principles of epidemiology in a simple but comprehensive form that it is hoped will be useful both to students and practitioners." Now, seven years later, they add: "Since the appearance of the First Edition, epidemiological thought has pervaded many branches of medicine widely, and the literature abounds with example of its application. Although this book is concerned with principles, which in the main have changed little, this development must be recognized. Accordingly the opportunity has been taken to revise the whole text."
A Population Perspective on Diabetes Prevention
Authors: James P. Burke, Ken Williams, K.M. Venkat Narayan, Cynthia Leibson, Steven M. Haffner, Michael P. Stern
Journal: Diabetes Care (2003)

To examine the influence of obesity and prevention of weight gain on the incidence of type 2 diabetes.We examined participants in the San Antonio Heart Study, a prospective population-based study of Mexican Americans and non-Hispanic whites residing in San Antonio, Texas. BMI was stratified into four categories: normal (<25 kg/m(2)), overweight (> or =25 kg/m(2) and <30 kg/m(2)), obese (> or =30 kg/m(2) and <35 kg/m(2)), and very obese (> or =35 kg/m(2)). The number and proportion of incident cases prevented by targeting each BMI category were estimated. In addition, we calculated the decrease in risk of developing type 2 diabetes associated with weight gain prevention across both the BMI and age spectra.Preventing normal individuals from becoming overweight would result in the greatest reduction in incidence of type 2 diabetes. This would result in a 62 and 74% reduction in the incidence of type 2 diabetes in Mexican Americans and non-Hispanic whites, respectively. Preventing the entire population from gaining, on average, 1 BMI unit would result in a reduction in incidence of type 2 diabetes of 12.4 and 13.0% in Mexican Americans and non-Hispanic whites, respectively.The majority of cases of type 2 diabetes were in individuals who were overweight or mildly obese with a family history of type 2 diabetes. Public health resources should be directed toward the prevention of weight gain among normal and overweight individuals in order to prevent the maximum number of cases of type 2 diabetes.
Rh Isoimmunization and Erythroblastosis Fetalis
Authors: A. S. Wiener
Journal: JAMA (1969)

A collaborative effort of 11 physicians from the Michael Reese Hospital, this book deals with the management of Rh hemolytic disease. It is limited almost exclusively to the classic problem of Rh 0 isosensitization, with only a single, oblique reference to A-B-O hemolytic disease. More esoteric problems, such as hr' or hr sensitization or iso-sensitization to blood factors of other blood-group systems, are not dealt with at all.  The book emphasizes chiefly problems of extreme Rh sensitization in which there has been a history of previous stillbirths due to Rh hemolytic disease and in which still another stillbirth is anticipated. There are detailed descriptions of amniocentesis and intrauterine transfusion. The authors admit to a 30% operative mortality for this relatively blind procedure; of 24 such transfused babies who were born alive, 12 died, making their total mortality 65%. The gestational age of these 24 babies at delivery, whether by spontaneous
Predictors of Outcome of Biventricular Repair in Infants With Multiple Left Heart Obstructive Lesions
Authors: Marcy L. Schwartz, Kimberlee Gauvreau, Tal Geva
Journal: Circulation (2001)

Decisions regarding surgical strategy in patients with multiple left heart obstructive or hypoplastic lesions often must be made in the newborn period and are seldom reversible. Predictors of outcome of biventricular repair have not been well defined in this heterogeneous group of patients, and risk factors described for critical aortic valve stenosis have been shown to be inapplicable to patients with other left heart obstructive lesions. The goal of this study was to identify echocardiographic predictors of outcome of biventricular repair for infants with multiple left heart obstructive lesions.Patients with >/=2 areas of left heart obstruction or hypoplasia, diagnosed at </=3 months of age, who had not previously undergone surgical or catheter intervention and maintained biventricular physiology were included (n=72). Failure of biventricular repair was defined as takedown to a univentricular repair, cardiac transplantation, and/or death (n=14; 19%). This group was compared with the patients who survived a biventricular approach (n=58). Multiple categorical, morphometric and calculated variables were examined on the basis of the initial echocardiograms. By multivariate analysis, predictors of failure included moderate/large ventricular septal defect (OR=22, P=0.001), unicommissural aortic valve (OR=16, P=0.006), and lower mitral valve dimension z-score (OR=2.2, P=0.02) or lower left ventricular end-diastolic volume z-score (OR=1.9, P=0.03).Moderate/large ventricular septal defect, unicommissural aortic valve, and hypoplastic mitral valve or left ventricle are independent risk factors for failure of biventricular repair for infants with multiple left heart obstructive lesions. Combinations of these risk factors may be useful in selecting surgical strategy.
Mammography: Technique, Diagnosis, Differential Diagnosis, Results
Authors: Franklin S. Alcorn
Journal: JAMA (1977)

Since mammography has achieved a position of singular importance in the management of breast disease in the United States, there has been a parallel development and use of this procedure in Europe, and the authors describe their experiences in some detail. In the first section of the monograph, the authors present the basic physical aspects of mammography technique and discuss the technical exposure problems. In a few pages with tables and graphs, supplemented by text, the essence of the physics of the self-radiation techniques is covered. The discussion of this aspect of mammography is as succinct and readily understandable as any that has been presented in many years. Pneumocystography, galactography, and cytology of the breast are also described, along with little-used techniques such as arteriography and lymphangiography of the breast. These chapters are documented with good references and are of interest, although pneumocystography is in all likelihood the only one
Carcinoma Presenting as Appendicitis
Authors: R. E. Candlin, M. A. Hossain
Journal: BMJ (1963)

ease with which they are unrecognized or ignored by the parents, who are themselves involved in the traumatic situation.This is a potent source of apparent backward- ness at school, which requires early diagnosis for a satis- factory cure.Although it is not suggested *that Dr.Newton's child (of whose sex I am unaware) has any of these, or any other defects, yet I would have thought that it would be at least pleasant to have the robust health of one's child confirmed by an independent expert.Unfortunately there are still ignorant and neglectful parents in the community, and so, regrettable as it may be, compulsory powers must be retained, so that their children should not be deprived of -the benefits of preventive medicine.-Iam, etc.,