tbuckley/cabot-search huggingface dataset:
The localization and activity of the leptins and adiponectins receptors in the thigh tissue in COPD-patients
Authors: Ekaterina Burtseva, Vera Nevzorova
Journal: European Respiratory Journal (2012)

Objective: To determine the localization and activity of receptors for leptin and adiponectin in the tissues of the thigh in patients with COPD.  The study included 90 patients with COPD (I stage, n = 30; II stage, n = 30, III stage, n = 30, control group n = 10). The samples of thigh tissue are obtained with fine-needle biopsy of the automatic MAGNUM system.The localization and activity of leptins and adiponectins receptors are studied using the immunofluorescence method and the quantification of the signals in the three fields of view, according to the protocol DakoCytomation. Positive expression of tags is observed in the cytoplasm and cell membrane.  The positive expression of the signals is obtained in the control group in the skin, connective tissue and muscle. The disappearance of signals to the adipokins in muscle tissue is observed with increasing of the stage of COPD. Receptor cell activity in leptin and adiponectin in COPD-patients varies and depends on the stage of the disease. The most significant decrease in the number of signals to leptin occurs in stage III disease as compared with the control group. In contrast, in the same group the quantity of signals for adiponectin increases and reaches a maximum level as compared with the control group.  The activity of the leptins and adiponectins receptors in muscle tissue disappears with the increasing of the COPD stage. Quantification of activity depends on the severity of the disease, the number of receptors to leptin decreases and the number of receptors to adiponectin increases.
<i>Mahabalipooram</i>
Authors: Jeanette M. Smith
Journal: JAMA (2015)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Delayed traumatic diaphragmatic hernia: Case series
Authors: Abdoulhossein Davoodabadi
Journal: European Respiratory Journal (2012)

background: 

Traumatic diaphragmatic rupture after blunt trauma is an uncommon condition. and often is initially missed diagnosis We report 6cases diaphragmatic rupture after blunt injury 2to16 years prior to admission.

Case 1: 37-year-old man with chronic vomiting abdomeminal pain and recently thoracic empyma, he had car accident 2 years ago. left thoracotomy revealed small perforation of stomach which repaired and reduced in abdominal cavity, then diaphragm repaired fig 1.

Case 2: 25 year-old man witm multipli injury 2 yeary ago admitted for acute abdomem,.thoracotomy revealed omntom and transverse colonin left hemi thorax .fig 2

Case 3: 43 year-old female with chest trauma in car accident at right posterolatrral thoracotomy revealed herniation of right liver iobe fig 3

Case 4: 29 year-old female with chest trauma and rib fractures 1n 3 yeary ago left posterolatrral thoracotomy revealed herniation of omentome left liver lobe some part of left coloc and stomach .after reduction of this organs diaphragm repaired fig1

Case 5: 47-year-old man with history of vomiting abdomeminal pain abd dyspnea in barium study stomach. Spleen transverse, colon small bowel lie in left hemi thorax with left l thoracotomy this organs reduced.diaphragm also repaired fig4-7

Case 6: 67 year-old man with history of vomiting abdomeminal pain, respiratory insufiency, sepsis he had car accident 16years ago left posterolatrral thoracotomy was done due to stomach torsion gangrene was happened. after operation the patient die

Conclusion .In patients with gastro intestinal complains and history of chest and abdominal trauma, must have high index suspicion to diaphragmatic injury.
Acetic Acid, a Potent Stimulator of Mouse Epidermal Macromolecular Synthesis and Hyperplasia but With Weak Tumor-Promoting Ability 2
Authors: T. J. Slaga, G. T. Bowden, R. K. Boutwell
Journal: JNCI Journal of the National Cancer Institute (1975)

The effects of a single application of various dose levels of acetic acid or the weak tumor promoter, phorbol-12,13-ditetradecanoate, on the incorporation of tritiated thymidine (3H-TDR), 3H-cytidine, and 3H-leucine into DNA, RNA, and protein of mouse epidermis, respectively, were determined and compared with histologic changes in the skin. Treatment with either 500 or 833 mumoles acetic acid induced a sequential and sustained stimulation of RNA, protein, and DNA synthesis, which was followed by extensive epidermal hyperplasia similar to that reported for the strong promoter and irritant, 12-O-tetradecanoyl-phorbol-13-acetate. A dose-response relationship between the amount of acetic acid and the rate of DNA synthesis was found between the dose levels of 33 to 833 mumoles of acetic acid per application. The latter dose induced the maximum activation of 3H-TDR into DNA at 723% of control at 2 days, whereas 33 mumoles stimulated DNA synthesis earlier and peaked at 210% of control at 3 hours. Phorbol-12,13-ditetradecanoate also stimulated macromolecular synthesis in a similar sequence, though to a lesser degree. No observable inflammation and only a slight hyperplastic response were noted with phorbol-12,13-ditetradecanoate. Weekly applications of 667 mumoles of acetic acid produced a maximal tumor response of 0.73 papilloma/mouse after 32 weeks of promotion. However, a weekly dose of 677 mumoles of acetic acid was essentially inactive when given in two divided doses. When croton oil was administered twice weekly at a 0.25%-dose level, 10.2 papillomas/mouse were induced after 32 weeks of promotion. The results showed that the previously considered nonpromoting inflammatory agent, acetic acid, must be a weak promoter. However, there was no correlation between stimulated macromolecular synthesis or hyperplasia and tumor promotion when phorbol esters were compared with acetic acid.
Abstract 14602: Osteopontin - A New Prognostic Biomarker in Patients with Cardiac Amyloidosis
Authors: Mark Rosenberg, Arnt V Kristen, Matthias Lutz, Ute Hegenbart, Stefan O Schoenland, Thomas J Dengler, Hugo A Katus, Norbert Frey
Journal: Circulation (2011)

Introduction and Hypothesis: Cardiac amyloidosis (CA) is associated with an adverse prognosis. However, even when clinical information is combined with biochemical and echocardiographic parameters,...
Bioassay Procedure for the Detection of Mutagenic Metabolites in Human Urine With the Use of Sister Chromatid Exchange Analysis&lt;xref ref-type="fn" rid="FN2"&gt;2&lt;/xref&gt;
Authors: R R Guerrero, D E Rounds, T C Hall
Journal: JNCI Journal of the National Cancer Institute (1979)

A short-term bioassay system for the detection of activated mutagenic metabolites in urine from humans exposed to promutagens was described. Human diploid fibroblasts were grown in medium containing 5--20% urine from smokers, from nonsmokers, and from individuals undergoing cyclophosphamide (Cp) chemotherapy for treatment of cancer. The cells were then subjected to sister chromatid exchange (SCE) analysis. Activated Cp metabolic products in urine specimens produced up to a ten-fold increase in SCE's over preinjection SCE levels for the same individuals. Linear dose-response curves over a urine concentration range from 5 to 20% in culture medium were obtained from cells grown in urine specimens from 7 nonsmokers and 8 cigarette smokers. This test system proved to be sensitive to ambient exposure levels of environmental mutagens and demonstrated that urine from smokers was significantly more mutagenic than was urine from nonsmokers. Replicate experiments showed highly reproducible SCE values for each individual as well as for average SCE values for each group of subjects. The ability of this bioassay system to detect trace mutagenic activity in human urine reproducibly makes it an attractive choice for the monitoring of humans who have been exposed to environmental and/or industrial mutagens.
Interactions of Early Mouse Embryos With Oncogenic Viruses—Simian Virus 40 and Polyoma. I. Ultrastructural Studies2
Authors: W. Biczysko, D. Solter, M. Pienkowski, H. Koprowski
Journal: JNCI Journal of the National Cancer Institute (1973)

Two-celled mouse embryos, blastocysts, and egg-cylinders were exposed to simian virus 40 (SV40) and polyoma virus. Uptake of SV40 but not of polyoma was found when 2-celled embryos were exposed to virus. Blastocysts and egg-cylinders exposed to SV40 or polyoma showed adsorption and uptake of virus particles. When infected blastocysts were grown in vitro for 96 hours, replication of virus in the nuclei of endodermal cells and uptake of newly synthesized virus by neighboring cells were found. Infected egg-cylinders grew in vitro and showed signs of organogenesis after 96 hours. Replication of SV40 and polyoma was observed in endodermal cells, yolk sac cells, and cells of blood islands. Uptake of newly synthesized viruses was found in the cells of the neural tube. Although mouse somatic cells are permissive for replication of polyoma but nonpermissive for replication of SV40, this difference was not observed in early embryos which were permissive for both viruses.
Further Observations on the Inhibition of Tumor Growth by Corynebacterium parvum With Cyclophosphamide. I. Variation in Administration of Both Agents2
Authors: Bernard Fisher, Norman Wolmark, Herbert Rubin, Elizabeth Saffer
Journal: JNCI Journal of the National Cancer Institute (1975)

Journal Article Further Observations on the Inhibition of Tumor Growth by Corynebacterium parvum With Cyclophosphamide. I. Variation in Administration of Both Agents Get access Bernard Fisher, M.D., Bernard Fisher, M.D. Search for other works by this author on: Oxford Academic PubMed Google Scholar Norman Wolmark, M.D., Norman Wolmark, M.D. Search for other works by this author on: Oxford Academic PubMed Google Scholar Herbert Rubin, M.D., Herbert Rubin, M.D. Search for other works by this author on: Oxford Academic PubMed Google Scholar Elizabeth Saffer Elizabeth Saffer Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 55, Issue 5, November 1975, Pages 1147–1153, https://doi.org/10.1093/jnci/55.5.1147 Published: 01 November 1975 Article history Received: 11 March 1975 Accepted: 23 June 1975 Published: 01 November 1975
Survival of Lung Cancer in East London: A Prospective Survey
Authors: F Festenstein, R M Weatherstone, M Rehahn
Journal: Journal of the Royal Society of Medicine (1988)

Five hundred men and 76 women all under the care of one physician at the London Chest Hospital were diagnosed as having bronchogenic carcinoma and admitted to a prospective survey between May 1966 and April 1978. The survey was completed in December 1984 when all but 19 of the 500 men had died. None was lost to follow up. The longest period of surveillance was 18 years 7 months, the shortest 6 years 8 months. The five-year survival of the group of 500 men was 7.6% (38), and 22% (32) for the 145 patients who had had resections. Of the 78 patients (63 men, 15 women) who had small cell carcinoma, only one survived 3 years; the others died in under 2 years, giving a median survival of 5 months. The median survival of the 21 untreated cases in this group of small cell carcinoma was 2 months.
Effects of caregiver depression on child depression and asthma: Mediation by inter-parent conflict and negative parenting
Authors: Beatrice Wood, JungHa Lim, Bruce Miller
Journal: European Respiratory Journal (2013)

Caregiver and child chronic stress and depression are linked with poor outcomes in child asthma, mediated by poor disease management and/or by psychobiologic stress mechanisms. Pathways of effect are unknown. Purpose: Our goal is to elucidate pathways. We hypothesize that parent depression contributes to inter-parent conflict and negative parenting which contribute to child depression (CD), which in turn predicts asthma disease activity (ADA). Methods: Asthmatic children (N=106,age 7-17), fathers and mothers were studied. Parent depression was indexed by self-report BDI. Inter-parent and parenting behavior was observed and rated during stressful family interaction tasks. The Iowa Family Rating Scale was used, intra-class correlations:79-.83. The CDI and Clinician Ratings indexed CD. NHLBI criteria indexed (ADA).Results: Structural equation modeling showed a pathway from mother depression (MD) to child depression (CD) mediated by negative parenting. X2 (32,N=106) =57.50,p=.004, IFI=.89, CFI=.87, RMSEA=.09. CD predicted ADA (B=.28,p=.05). Father depression (FD) was linked to negative parenting (B=.29,p=.001) and to inter-parent conflict (B=.32,p=.01) but father negative parenting was not linked to CD. However, FD contributed to inter-parent conflict which contributed to negative MATERNAL parenting which was linked with CD and ADA. Conclusions: MD predicted CD and ADA, mediated by negative parenting, whereas FD predicted inter-parent conflict, which predicted CD and ADA mediated by maternal negative parenting. These findings suggest that father and mother depression both play a role in child depression and asthma disease activity, but through different pathways.
Methotrexate and cyclosporine versus cyclosporine alone for prophylaxis of graft-versus-host disease in patients given HLA-identical marrow grafts for leukemia: long-term follow-up of a controlled trial
Authors: R Storb, HJ Deeg, M Pepe, F Appelbaum, C Anasetti, P Beatty, W Bensinger, R Berenson, CD Buckner, R Clift
Journal: Blood (1989)
Letrozole, a new oral aromatase inhibitor for advanced breast cancer: double-blind randomized trial showing a dose effect and improved efficacy and tolerability compared with megestrol acetate.
Authors: P Dombernowsky, I Smith, G Falkson, R Leonard, L Panasci, J Bellmunt, W Bezwoda, G Gardin, A Gudgeon, M Morgan, A Fornasiero, W Hoffmann, J Michel, T Hatschek, T Tjabbes, H A Chaudri, U Hornberger, P F Trunet
Journal: Journal of Clinical Oncology (1998)

PURPOSE To compare two doses of letrozole and megestrol acetate (MA) as second-line therapy in postmenopausal women with advanced breast cancer previously treated with antiestrogens. PATIENTS AND METHODS Five hundred fifty-one patients with locally advanced, locoregionally recurrent or metastatic breast cancer were randomly assigned to receive letrozole 2.5 mg (n = 174), letrozole 0.5 mg (n = 188), or MA 160 mg (n = 189) once daily in a double-blind, multicenter trial. Data were analyzed for tumor response and safety variables up to 33 months of follow-up evaluation and for survival up to 45 months. RESULTS Letrozole 2.5 mg produced a significantly higher overall objective response rate (24%) compared with MA (16%; logistic regression, P = .04) or letrozole 0.5 mg (13%; P = .004). Duration of objective response was significantly longer for letrozole 2.5 mg compared with MA (Cox regression, P = .02). Letrozole 2.5 mg was significantly superior to MA and letrozole 0.5 mg in time to treatment failure (P = .04 and P = .002, respectively). For time to progression, letrozole 2.5 mg was superior to letrozole 0.5 mg (P = .02), but not to MA (P = .07). There was a significant dose effect in overall survival in favor of letrozole 2.5 mg (P = .03) compared with letrozole 0.5 mg. Letrozole was significantly better tolerated than MA with respect to serious adverse experiences, discontinuation due to poor tolerability, cardiovascular side effects, and weight gain. CONCLUSION The data show letrozole 2.5 mg once daily to be more effective and better tolerated than MA in the treatment of postmenopausal women with advanced breast cancer previously treated with antiestrogens.
Plasmablastic Morphology Is an Independent Predictor of Poor Survival After Autologous Stem-Cell Transplantation for Multiple Myeloma
Authors: S. Vincent Rajkumar, Rafael Fonseca, Martha Q. Lacy, Thomas E. Witzig, Terry M. Therneau, Robert A. Kyle, Mark R. Litzow, Morie A. Gertz, Philip R. Greipp
Journal: Journal of Clinical Oncology (1999)

PURPOSE: To study the prognostic value of plasmablastic morphology after autologous stem-cell transplantation for relapsed or primary refractory myeloma. PATIENTS AND METHODS: Seventy-five patients were studied. Investigators blinded to the clinical details of the individual cases reviewed bone marrow aspirate slides to determine plasmablastic classification. Plasmablasts were defined using strict, well-described criteria. Plasmablastic morphology was considered to be present (plasmablastic myeloma) when 2% or more plasmablasts were present in the plasma-cell population. RESULTS: Patients underwent transplantation 5 to 88 months (median, 20 months) after the initial diagnosis of myeloma. Twenty-eight percent of patients had plasmablastic morphology. A significantly greater proportion of patients with plasmablastic morphology had abnormal cytogenetics compared with those with nonplasmablastic classification (73% v 31%, respectively; P = .003). The overall survival rate measured from the time of transplantation was significantly worse in patients with plasmablastic morphology compared with those without (median survival time, 5 months v 24 months, respectively; P &lt; .001). Progression-free survival time was shortened also, with a median time of 4 months compared with 12 months, respectively (P &lt; .001). In the multivariate analysis, plasmablastic classification was the most powerful prognostic factor after transplantation for both overall (P = .001) and progression-free survival rates (P &lt; .001). We also identified three risk groups based on plasmablastic morphology: plasma-cell labeling index, lactate dehydrogenase, and cytogenetics. The median overall survival time was 38 months when none of these factors was abnormal, 17 months with one abnormal factor, and 8 months with two or more abnormal factors (P &lt; .001). CONCLUSION: Plasmablastic morphology is a powerful independent predictor of poor survival rate after autologous stem-cell transplantation for relapsed or primary refractory myeloma.
Risk prediction models for contrast induced nephropathy: systematic review
Authors: Samuel A Silver, Prakesh M Shah, Glenn M Chertow, Shai Harel, Ron Wald, Ziv Harel
Journal: BMJ (2015)

<b>Objectives</b> To look at the available literature on validated prediction models for contrast induced nephropathy and describe their characteristics. <b>Design</b> Systematic review. <b>Data sources</b> Medline, Embase, and CINAHL (cumulative index to nursing and allied health literature) databases. <b>Review methods</b> Databases searched from inception to 2015, and the retrieved reference lists hand searched. Dual reviews were conducted to identify studies published in the English language of prediction models tested with patients that included derivation and validation cohorts. Data were extracted on baseline patient characteristics, procedural characteristics, modelling methods, metrics of model performance, risk of bias, and clinical usefulness. Eligible studies evaluated characteristics of predictive models that identified patients at risk of contrast induced nephropathy among adults undergoing a diagnostic or interventional procedure using conventional radiocontrast media (media used for computed tomography or angiography, and not gadolinium based contrast). <b>Results</b> 16 studies were identified, describing 12 prediction models. Substantial interstudy heterogeneity was identified, as a result of different clinical settings, cointerventions, and the timing of creatinine measurement to define contrast induced nephropathy. Ten models were validated internally and six were validated externally. Discrimination varied in studies that were validated internally (C statistic 0.61-0.95) and externally (0.57-0.86). Only one study presented reclassification indices. The majority of higher performing models included measures of pre-existing chronic kidney disease, age, diabetes, heart failure or impaired ejection fraction, and hypotension or shock. No prediction model evaluated its effect on clinical decision making or patient outcomes. <b>Conclusions</b> Most predictive models for contrast induced nephropathy in clinical use have modest ability, and are only relevant to patients receiving contrast for coronary angiography. Further research is needed to develop models that can better inform patient centred decision making, as well as improve the use of prevention strategies for contrast induced nephropathy.
Survival Rates in Trauma Patients Following Health Care Reform in Massachusetts
Authors: Turner Osler, Laurent G. Glance, Wenjun Li, Jeffery S. Buzas, David W. Hosmer
Journal: JAMA Surgery (2015)

Massachusetts introduced health care reform (HCR) in 2006, expecting to expand health insurance coverage and improve outcomes. Because traumatic injury is a common acute condition with important health, disability, and economic consequences, examination of the effect of HCR on patients hospitalized following injury may help inform the national HCR debate.
Biological Properties of B Particles From C3H and C3Hf Mouse Milk
Authors: Philomena C. Hageman, J. Links, P. Bentvelzen
Journal: JNCI Journal of the National Cancer Institute (1968)

B particles were isolated from C3H and C3Hf mouse milk by ultracentrifugation in Ficoll density gradients. Quantities of B particles with the same optical density in ultraviolet light were compared for their tumorigenic activity in BALB/c mice. The high mammary-tumor-virus activity of C3H B particles was confirmed. After this preparation was diluted 10,000 times it still had tumorigenic activity. An undiluted preparation of C3Hf B particles did not induce mammary tumors before 300 days. This indicated the presence, in C3Hf mice, of another virus with the morphology of B particles and less or no carcinogenic activity. Injection of a mixture of equal amounts of B particles from both sources did not decrease the tumor incidence as compared to the C3H B particles alone, which thus excludes the possibility of an inhibitor in the C3Hf B-particle preparation. Addition of a 1000-fold higher concentration of C3Hf B particles to a threshold dose of C3H B particles greatly increased the tumor incidence.