tbuckley/cabot-search huggingface dataset:
RETRODISPLACEMENT OF THE UTERUS AS AN OBSTETRIC COMPLICATION
Authors: E. D. PLASS
Journal: JAMA (1930)

Retroposition of the uterus as an obstetric complication is not a new subject for discussion by this section or by obstetricians generally, but apparently no attempt has been made to learn what will happen if no corrective treatment is instituted during pregnancy or after delivery. Various degrees of conservatism have been advocated from time to time until the retroverted uterus has lost a great deal of its former importance, but there is still a feeling that it is a real complication. Among obstetricians it is frequently blamed for sterility and for early abortion, and the advice is usually given that a retroposed uterus discovered in early pregnancy should be replaced at once, lest untoward symptoms develop. Moreover, there is a strong feeling that child-bearing plays an important rôle in producing posterior displacements and that it is essential for the physician to insist on correctional exercises and to institute pessary treatment
Mechanism of Sweating From Tricyclics-Reply
Authors: Robert M. A. Hirschfeld
Journal: JAMA (1979)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Effects of perhexiline maleate on coronary flow distribution in the ischemic canine myocardium.
Authors: G A Klassen, F Sestier, A L'Abbate, R R Mildenberger, D T Zborowska-Sluis
Journal: Circulation (1976)

Intravenous perhexiline maleate in a canine preparation with fixed coronary flow increases coronary diastolic pressure. It also redistributes coronary flow so as to preserve endocardial flow. Myocardial oxygen consumption was reduced and lactate uptake enhanced by the drug. It had no effect upon the threshold for ischemic-induced left ventricular failure.
Preexisting pancreatic acinar cells contribute to acinar cell, but not islet β cell, regeneration
Authors: Biva M. Desai, Jennifer Oliver-Krasinski, Diva D. De Leon, Cyrus Farzad, Nankang Hong, Steven D. Leach, Doris A. Stoffers
Journal: Journal of Clinical Investigation (2007)

It has been suggested that pancreatic acinar cells can serve as progenitors for pancreatic islets, a concept with substantial implications for therapeutic efforts to increase insulin-producing β cell mass in patients with diabetes. We report what we believe to be the first in vivo lineage tracing approach to determine the plasticity potential of pancreatic acinar cells. We developed an acinar cell–specific inducible Cre recombinase transgenic mouse, which, when mated with a reporter strain and pulsed with tamoxifen, resulted in permanent and specific labeling of acinar cells and their progeny. During various time periods of observation and using several models to provoke injury, we failed to observe any chase of the labeled cells into the endocrine compartment, indicating that acinar cells do not normally transdifferentiate into islet β cells in vivo in adult mice. In contrast, we observed a substantial role for replication of preexisting acinar cells in the regeneration of new acinar cells after partial pancreatectomy. These results indicate that mature acinar cells harbor a facultative acinar but not endocrine progenitor capacity.
MEDICAL TREATMENT OF CHRONIC NONSPECIFIC INFECTIONS OF LUNGS AND BRONCHI IN CHILDREN
Authors: JOSEPH BRENNEMANN
Journal: JAMA (1926)

<h3>[Editorial Note.</h3> —This paper, together with the paper by Dr. Graham, which follows it, concludes the symposium on "Chronic Nonspecific Infections of the Lungs and Bronchi." The last issue ofThe Journalcontained the papers by Dr. Jackson, Dr. Morse and Dr. Mullin.] The medical treatment of chronic nonspecific infections of the lungs and bronchi in children is a topic that admits of individual interpretation and requires definition. Under "chronic nonspecific infections of the lungs and bronchi" I shall include chronic bronchitis, together with recurrent bronchitis, both simple and asthmatic; unresolved pneumonia; lung abscess, bronchiectasis, and certain types of massive collapse of the lung; and chronic empyema. Under "medical" treatment I shall include not only such measures as I, a nonsurgical man, would suggest in the treatment of chronic nonspecific infections of the lungs and bronchi; but also such advise as I, a medical man, might give with reference to
Circulation/Cardiology 2
Authors: Patrice Morville, Pierre Mauran, Laurence Desplanques, Laurent Egreteau, Brigitte Santerne, G. Balling, A. Eicken, W. Sebening, M. Vogt, G. Schumacher, K. Bühlmeyer, James J. McGovern, Damian M. Craig, A. Resai Bengur, Ira M. Cheifetz, Peter K. Smith, Ross M. Ungerleider, Jon N. Meliones, Keith C. Kocis, A. Rebecca Snider, Frank H. Kern, Scott S. Schulman, Barbara G. Wilson, Bea Baldwin, William Greeley
Journal: Intensive Care Medicine (1996)
Effects of swimming training on aerobic capacity and exercise induced bronchoconstriction in children with bronchial asthma
Authors: I Matsumoto, H Araki, K Tsuda, H Odajima, S Nishima, Y Higaki, H Tanaka, M Tanaka, M Shindo
Journal: Thorax (1999)

<h3>BACKGROUND</h3> A study was undertaken to determine whether swimming training improved aerobic capacity, exercise induced bronchoconstriction (EIB), and bronchial responsiveness to inhaled histamine in children with asthma. <h3>METHODS</h3> Eight children with mild or moderate asthma participated in swimming training every day for six weeks. The intensity of training was individually determined and set at 125% of the child’s lactate threshold (LT), measured using a swimming ergometer. Another group of eight asthmatic children served as control subjects. Aerobic capacity and the degree of EIB were assessed by both cycle ergometer and swimming ergometer before and after swimming training. <h3>RESULTS</h3> The mean (SD) aerobic capacity at LT increased by 0.26 (0.11) kp after training when assessed with the swimming ergometer and by 10.6 (4.5) W when assessed with the cycle ergometer, and these changes were significantly different from the control group. The mean (SD) maximum % fall in forced expiratory volume in one second (FEV<sub>1</sub>) to an exercise challenge (cycle ergometer) set at 175% of LT decreased from 38.7 (15.4)% before training to 17.9 (17.6)% after training, but with no significant difference from the control group. There was, however, no difference in histamine responsiveness when compared before and after the training period. <h3>CONCLUSION</h3> A six week swimming training programme has a beneficial effect on aerobic capacity but not on histamine responsiveness in children with asthma.
THE TREATMENT OF INFANTILE TETANY BY CALCIUM CHLORIDE
Authors: S. Graham, G. H. Anderson
Journal: BMJ (1924)

Other powerful forces were also at work on the social revolution of the country.The capture of Constantinopre by the Turks in 1453 and the flight of the Greek scholars to Italy opened anew the science and literature of the old world, and a stage of development in Italy, extending to, nearly half a century, was followed by the diffusion of the " new learning " over other countries in Europe.The discovery of printing, about this time, led to the rapid and widespread distribution of books.This, again, occasioned a vast increase in the number of schools, and more were founded in the last years of the reign of Henry VIII than in the three preceding centuries.The pace thus set was accelerated in the reigns of Edward and Elizabeth.The translation and publication of the Bible at this time had a marked influence on society.Copies were provided in all the churches, and it thus became, in truth, the book of the people, so that their very thoughts and speech were affected by it.This religious revival, fostered by Luther, Calvin, and Knox, brought about the Reforma- tion with its long and bitter wars.
The endoscopically normal colon - when is mapping biopsy histopathologically justifiable?
Authors: V. J. Elliot, A. C. Bateman, B. Green
Journal: Gut (2011)

<h3>Introduction</h3> Mapping biopsy of the endoscopically normal colorectum is contentious1–3 and histopathological review of such biopsies is labour intensive. At a time when increasing efficiency and managing demand for pathological testing are key healthcare priorities, we aimed to identify situations where biopsy practice could be streamlined, without a detrimental impact on patients. <h3>Methods</h3> Using our laboratory database, a search using the SNOMED system, retrieved cases coded as ‘colonic mapping biopsy’ over a 6 month period. The information was correlated with relevant endoscopy and pathology reports. The data were anonymised and entered on an Excel spreadsheet for analysis. <h3>Results</h3> 360 cases were retrieved. 165 (46%) were considered endoscopically normal/near normal. 151 (92%) with endoscopically normal/near normal mucosa showed normal/near normal histology. 14 (8%) endoscopically normal/near normal cases yielded a positive pathological diagnosis - melanosis coli (5), lymphocytic colitis (2), minimally active colitis (1), colitis unspecified (1), inflammatory bowel disease unspecified (1), inflammatory bowel disease of ulcerative colitis type (2), atrophy (1) and proctitis (1). Of the 360 cases studied, 164 (46%) were referred with the clinical indication ‘change in bowel habit’ or ‘colitis’. (The 69 cases referred to endoscopy with ‘colitis’ included approximately two thirds follow-up cases with a known diagnosis and around one third without a pre-existing diagnosis). The remaining 196 (54%) cases were referred for various indications including iron deficiency anaemia and rectal bleeding. Positive diagnoses were yielded only from patients with ‘change in bowel habit’ or ‘colitis’. No diagnoses were yielded from any other group. <h3>Conclusion</h3> We have confirmed that pathological yield from biopsy of the endoscopically normal colon is highest in patients referred with ‘change in bowel habit’ or ‘colitis’. We support biopsy in this cohort of individuals. However, mapping biopsy from endoscopically normal colonic mucosa in patients referred for other indications (eg, investigation of rectal bleeding or iron deficiency anaemia) should not be performed routinely as diagnostic yields are extremely low. Streamlining patients for biopsy on the basis of indication for referral would be a useful step in developing clinical protocols on when mapping biopsy of the endoscopically normal colon is histopathologically justifiable.
Withdrawal of Acetylcholine Elicits Ca <sup>2+</sup> -Induced Delayed Afterdepolarizations in Cat Atrial Myocytes
Authors: Y.G. Wang, J. Hüser, L.A. Blatter, S.L. Lipsius
Journal: Circulation (1997)

Background Recent experiments in atrial myocytes indicate that withdrawal of cholinergic agonist can directly increase Ca 2+ influx via L-type Ca 2+ current and stimulate Ca 2+ uptake into the sarcoplasmic reticulum (SR), thereby increasing intracellular Ca 2+ . Overload of cellular Ca 2+ within the SR can initiate various types of atrial dysrhythmias. The present study was designed to determine whether withdrawal of acetylcholine (ACh) can elicit Ca 2+ -induced delayed afterdepolarizations (DADs) in atrial myocytes. Methods and Results A nystatin perforated-patch whole-cell method and fluorescence microscopy (indo 1) were used to measure electrical activities and intracellular free Ca 2+ ([Ca 2+ ] i ), respectively. Withdrawal of ACh (1 μmol/L) increased action potential duration, shifted plateau voltage toward positive, and generated DADs that initiated spontaneous action potentials. Voltage-clamp analysis revealed that withdrawal of ACh elicited a rebound stimulation of L-type Ca 2+ current ( I Ca,L ) (+45%) and Na/Ca exchange current ( I NaCa ) (+16%) and the appearance of transient inward current ( I ti ) and spontaneous [Ca 2+ ] i transients. Each of these changes induced by withdrawal of ACh was abolished by Rp-cAMPs (50 to 100 μmol/L) or H-89 (2 μmol/L), inhibitors of cAMP-dependent protein kinase A. Ryanodine (1 μmol/L) abolished I NaCa and the appearance of I ti without decreasing the rebound stimulation of I Ca,L elicited by withdrawal of ACh. Conclusions Withdrawal of ACh can elicit cAMP-mediated stimulation of Ca 2+ influx via I Ca,L and uptake of SR Ca 2+ . As a result, cellular Ca 2+ overload causes enhanced SR Ca 2+ release and the initiation of DADs. These mechanisms may generate triggered and/or spontaneous atrial depolarizations elicited by withdrawal of vagal nerve activity.
Treatment of Acute Abdominal and Facial Attacks of Hereditary Angioedema (HAE) with Human C1 Esterase Inhibitor (C1-INH): Results of a Global, Multicenter, Randomized, Placebo-controlled, Phase II/III Study (I.M.P.A.C.T.1)
Authors: J.A. Bernstein, R. Levy, R.L. Wasserman, A. Bewtra, D. Hurewitz, K. Obtulowicz, A. Reshef, P.C. Kiessling, T.J. Craig
Journal: Journal of Allergy and Clinical Immunology (2008)
Lupus-Erythematosus-like Tinea of the Face (Tinea Faciale)
Authors: Robert S. Gilgor
Journal: JAMA (1971)

Fourteen patients had superficial fungus infections of their faces. Over half of them were misdiagnosed, usually as a sunlight-related disorder. The correct diagnosis can usually be made by direct examination of scales or blister roofs, taken from affected areas, or by fungus culture. All patients responded rapidly to antifungal treatment.
Management of Depression in the Patient With Advanced Cancer
Authors: Richard J. Goldberg
Journal: JAMA (1981)

AS MEDICAL therapies continue to lengthen survival time of patients with illnesses, quality of survival and the emotional consequences of illness and its treatment become more prominent. While many physicians generally assume that the distress associated with cancer is accounted for by the physical morbidity, it is now appreciated that at least half of the distress associated with cancer is due to issues involving emotional and social adjustment. Depression in some form is an issue that must be faced by many patients and clinicians dealing with advanced cancer and is the most frequent reason for psychiatric referral in this population. However, the development of a systematic approach to the evaluation of depression in cancer patients has been hampered by the scientifically unsupported general view that depression is a natural part of the disease and that all cancer patients are depressed. The question "Wouldn't you be depressed if you had cancer?"
A frontline triage system across different health settings
Authors: J. Y. Verbakel, F. Buntinx, M. Thompson
Journal: BMJ (2013)

De and colleagues present the validation results of the National Institute for Health and Care Excellence (NICE) “traffic light” system to detect serious bacterial infections in young children with fever.1 Such research is welcome, because timely recognition of the small number of children with serious bacterial infections among the majority with self limiting infections is difficult and consumes considerable frontline healthcare resources.2

We recently examined the diagnostic accuracy of several clinical prediction rules, including the NICE traffic light system with any amber or red feature present, …
Thyroid surgery for Graves' disease.
Authors: A D Toft
Journal: BMJ (1983)

tion in the activity of earlier preparations from one batch to another have caused confusion in comparing results.Clearly interferon is not to cancer what penicillin was to bacterial infection.Nevertheless, it may still have a part to play in the treatment of cancer and only careful clinical and labora- tory research in centres familiar with the rigours of such investigation can determine its eventual role in clinical oncology.
Respiratory modulation of muscle sympathetic nerve activity in intact and lung denervated humans.
Authors: D R Seals, N O Suwarno, M J Joyner, C Iber, J G Copeland, J A Dempsey
Journal: Circulation Research (1993)

We determined the influences of breathing-induced changes in intrathoracic and intravascular pressures, central respiratory drive, and pulmonary vagal feedback on the within-breath variation in skeletal muscle sympathetic nerve activity (MSNA) in humans. MSNA (peroneal microneurography), arterial blood pressure (Finapres finger monitor), and tidal volume (VT) were recorded continuously in six normal subjects and four heart-lung transplant patients during: 1) spontaneous air breathing; 2) increased FICO2; 3) voluntary augmentation of VT with and without inspiratory resistance; and 4) positive pressure, passive mechanical ventilation. During conditions 3 and 4, which were performed under isocapnic conditions with a high MSNA background (either high resting activity or nonhypotensive lower body suction), subjects breathed at control or elevated VT with normal or prolonged inspiratory time (TI); breathing frequency was 12 breaths per minute. During control breathing in normal subjects there was a distinct within-breath pattern of MSNA, with approximately 70% of the activity occurring during low lung volumes (initial half of inspiration and latter half of expiration). This within-breath variation of MSNA was potentiated with increased VT breathing (&gt; 85% of activity occurring during low lung volumes; p &lt; 0.05 versus control breathing) and was similar during the voluntary and CO2-induced hyperpneas. MSNA decreased progressively and markedly from onset to late inspiration; fell slightly further, reaching its nadir at end-inspiration/onset-expiration; and rose sharply during mid-late expiration. Only the nadir of MSNA was associated with any change in arterial pressure. Resistive breathing, especially at elevated VT, caused a fall in arterial pressure and increased respiratory drive during inspiration, yet MSNA still declined as lung volume increased. Normal within-breath modulation of MSNA also was observed during control and elevated VT induced via positive pressure with passive ventilation, which reversed lung inflation/deflation-induced intrathoracic pressure changes and reduced or removed respiratory motor output. During control breathing in transplant patients the specific within-breath pattern of MSNA was somewhat different than that of the normal subjects, but on average, the overall low lung volume to high lung volume MSNA ratio was similar to normal subjects. In contrast to the normal subjects, however, there was no potentiation of the within-breath variation of MSNA with elevated tidal breathing. These findings indicate that during normal levels of tidal breathing most of the respiratory phase influence on muscle sympathetic outflow observed in normal conscious humans is independent of baroreceptor-sensed fluctuations in intrathoracic or intravascular pressures and of lung inflation-stimulated vagal afferent activity.(ABSTRACT TRUNCATED AT 400 WORDS)
Mislocalization of DNAH5 and DNAH9 in Respiratory Cells from Patients with Primary Ciliary Dyskinesia
Authors: Manfred Fliegauf, Heike Olbrich, Judit Horvath, Johannes H. Wildhaber, Maimoona A. Zariwala, Marcus Kennedy, Michael R. Knowles, Heymut Omran
Journal: American Journal of Respiratory and Critical Care Medicine (2005)

Primary ciliary dyskinesia (PCD) is a genetically heterogeneous disorder characterized by recurrent infections of the airways and situs inversus in half of the affected offspring. The most frequent genetic defects comprise recessive mutations of DNAH5 and DNAI1, which encode outer dynein arm (ODA) components. Diagnosis of PCD usually relies on electron microscopy, which is technically demanding and sometimes difficult to interpret.Using specific antibodies, we determined the subcellular localization of the ODA heavy chains DNAH5 and DNAH9 in human respiratory epithelial and sperm cells of patients with PCD and control subjects by high-resolution immunofluorescence imaging. We also assessed cilia and sperm tail function by high-speed video microscopy.In normal ciliated airway epithelium, DNAH5 and DNAH9 show a specific regional distribution along the ciliary axoneme, indicating the existence of at least two distinct ODA types. DNAH5 was completely or only distally absent from the respiratory ciliary axoneme in patients with PCD with DNAH5- (n = 3) or DNAI1- (n = 1) mutations, respectively, and instead accumulated at the microtubule-organizing centers. In contrast to respiratory cilia, sperm tails from a patient with DNAH5 mutations had normal ODA heavy chain distribution, suggesting different modes of ODA generation in these cell types. Blinded investigation of a large cohort of patients with PCD and control subjects identified DNAH5 mislocalization in all patients diagnosed with ODA defects by electron microscopy (n = 16). Cilia with complete axonemal DNAH5 deficiency were immotile, whereas cilia with distal DNAH5 deficiency showed residual motility.Immunofluorescence staining can detect ODA defects, which will possibly aid PCD diagnosis.
Alternative Pricing Strategies for Cancer Drugs
Authors: Andrea Messori, Mauro De Rosa, Luca Pani
Journal: JAMA (2015)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal