tbuckley/cabot-search huggingface dataset:
Abstract 25: Six-year Change in C-reactive Protein Levels and Risk of Incident Diabetes, Cardiovascular Events and Mortality
Authors: Christina M Parrinello, Pamela L Lutsey, Christie M Ballantyne, Aaron R Folsom, James S Pankow, Elizabeth Selvin
Journal: Circulation (2014)

Background: High levels of C-reactive protein (CRP) are associated with cardiovascular disease, diabetes and mortality. It is unclear whether changes in CRP or persistently high CRP are associated with these outcomes beyond the baseline measure. Methods: We conducted a prospective cohort analysis of 10,229 participants from the ARIC Study with two measurements of CRP six years apart (at visits 2 and 4, 1990-92 and 1996-98, respectively). CRP was categorized into two groups using a standard cut-point for defining high levels (≥3 vs. &lt;3 mg/L). Six-year change in CRP was categorized as: persistently not high (&lt;3 mg/L), decreasing (≥3 to &lt;3 mg/L), increasing (&lt;3 to ≥3 mg/L), and persistently high (≥3 mg/L). Cox proportional hazards models were used to assess the association between visit 2 CRP, visit 4 CRP and six-year change in CRP and each of the following outcomes from visit 4 through 2010: diabetes, coronary heart disease, ischemic stroke, heart failure and all-cause mortality. Models were adjusted for traditional risk factors at visit 2. Sensitivity analyses additionally adjusted for visit 4 covariates. Results: Persons with CRP ≥3 mg/L at visit 2 or 4 had higher risk of each outcome compared to those with CRP &lt;3 mg/L ( Table ). We observed higher risk of all outcomes in persons with persistently high CRP, and of all outcomes except stroke in persons with increasing CRP, compared to those with CRP &lt;3 mg/L at both visits ( Table ). Persons whose CRP decreased from high to &lt;3 mg/L did not have significantly increased risk of cardiovascular outcomes or diabetes compared to those with CRP persistently &lt;3 mg/L. Results were similar after adjusting for visit 4 covariates. Conclusions: Persons with sustained high levels of CRP or whose CRP increased to high levels had higher risk of diabetes, cardiovascular disease, and death, while those whose levels decreased from high to moderate or low were at lower risk. Multiple measures of CRP may better characterize inflammatory status and provide more comprehensive information regarding long-term risk.
Platelet glycoprotein VI binds to polymerized fibrin and promotes thrombin generation
Authors: Elmina Mammadova-Bach, Véronique Ollivier, Stéphane Loyau, Mathieu Schaff, Bénédicte Dumont, Rémi Favier, Geneviève Freyburger, Véronique Latger-Cannard, Bernhard Nieswandt, Christian Gachet, Pierre H. Mangin, Martine Jandrot-Perrus
Journal: Blood (2015)
Meningitis C rates show steep fall
Authors: Jacqui Wise
Journal: BMJ (2001)

The number of cases of meningitis C has dropped dramatically in the United Kingdom since the introduction of an immunisation programme just over a year ago. Government figures show that in the past six months there has been a 90% reduction in cases among 15-17 year olds—down from 50 cases in 1999 to five in 2000.

Last year there were six cases of meningitis in babies under 1 year old, compared with 32 cases in 1999, a reduction …
Importance of mitral regurgitation inpatients undergoing percutaneous coronaryintervention for acute myocardial infarction
Authors: Gregory G. Pellizzon, Cindy L. Grines, David A. Cox, Thomas Stuckey, James E. Tcheng, Eulogio Garcia, Giulio Guagliumi, Mark Turco, Alexandra J. Lansky, John J. Griffin, David J. Cohen, Eve Aymong, Roxana Mehran, William W. O'Neill, Gregg W. Stone
Journal: Journal of the American College of Cardiology (2004)
Diesel Fumes and Allergies
Authors: Tracy Hampton
Journal: JAMA (2004)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Identification of bromodomain-containing protein-4 as a novel marker and epigenetic target in mast cell leukemia
Authors: Ghaith Wedeh, Sabine Cerny-Reiterer, Gregor Eisenwort, Harald Herrmann, Katharina Blatt, Emir Hadzijusufovic, Irina Sadovnik, Leonhard Müllauer, Juliana Schwaab, Thomas Hoffmann, James E. Bradner, Deepti Radia, Wolfgang R. Sperr, Gregor Hoermann, Andreas Reiter, Hans-Peter Horny, Johannes Zuber, Michel Arock, Peter Valent
Journal: Leukemia (2015)
Increased expression of gelatinases and collagenase in rat lungs exposed to 100% oxygen.
Authors: A Pardo, M Selman, K Ridge, R Barrios, J I Sznajder
Journal: American Journal of Respiratory and Critical Care Medicine (1996)

Exposure of adult rats to 100% O2 produces a lethal injury by 72 h. We reasoned that matrix metalloproteinases participate in the pathogenesis of hyperoxic lung injury. To that end we studied the expression and activity of gelatinases A and B and interstitial collagenase in lung tissues and bronchoalveolar lavage fluids (BALF) of rats exposed to 100% oxygen for 60 h. Gelatin zymography of BALF samples revealed a 472 kDa molecular species both in controls and oxygen-exposed animals. In addition, BALF from hyperoxic rats exhibited a 95-kDa gelatinase. Likewise, BALF total gelatinolytic and collagenolytic activities were significantly increased in oxygen-exposed rats. In situ hybridization revealed an increase in type IV collagenases as well as interstitial collagenase mRNAs in the oxygen-exposed lungs. The three enzymes were expressed by alveolar macrophages, and in variable degrees by interstitial and alveolar epithelial cells. Immunoreactive gelatinase B and collagenase paralleled the cell localization of the mRNAs but were also detected in the alveolar walls and interstitium. In situ zymography showed gelatinolytic activity in frozen sections of oxygen-exposed lungs but not in normal lungs. The upregulation of these metalloproteinases during acute exposure to 100% O2 suggests that they might contribute to hyperoxic lung damage through the degradation of extracellular matrix components.
Abstract 62: The Role of Physical Activity in the Hypertension Pathway: A longitudinal pathway-based analysis across 18 years in modernizing China
Authors: Annie Green Howard, Penny Gordon-Larsen, Amy Herring, Shufa Du, Barry Popkin
Journal: Circulation (2014)

Background: Urbanization is associated with a decline in physical activity and an increase in CVD, particularly hypertension in lower and middle income countries. We investigate the impact of modernization-related declines in physical activity and pathways through body mass to hypertension in Chinese adults. Methods: Data come from the China Health and Nutrition Survey (CHNS), a household-based study that covers 9 diverse Chinese provinces from 1991 to 2009 across eight waves of data (n=12,018 adults; aged 18-66). We used detailed activity recall across multiple domains (leisure, work, and home), 3 repeated 24-hour-dietary-recalls, measured anthropometry and blood pressure at each exam. We created a multi-level structural equation model in Mplus to estimate direct pathways from specific domains of physical activity to hypertension and indirect paths through BMI. All pathways, including pathways to physical activity domains, were adjusted for gender, age, socioeconomic factors, urbanicity and region. Hypertension-related dietary factors were included in all pathways to BMI and hypertension. Results: The impact of physical activity on hypertension was most notable in the direct pathway to hypertension. Occupational and leisure activity were significantly associated with hypertension (p-value &lt; 0.001), and individuals who were more active were less likely to have hypertension. Estimated from this model, a typical active, highly-educated, high-income middle aged female has a 12% probability of having hypertension, compared to a 43% probability for a similar non-active woman. There was however no direct association between physical activity and BMI. Conclusions: In China, declining physical activity over 18 years of modernization is strongly and directly related to increasing hypertension prevalence, with little evidence for effects along the pathway through BMI. Given continued declines in leisure and occupational activity, it is unlikely that hypertension will decline without additional intervention.
924. Gene Therapy with IGF-1 Growth Factor for Heart Failure
Authors: Armelle Serose, Andre Salmon, Bernard Prudhon, Marie Agnes Doyennette, Marc Y. Fiszman, Yves Y. Fromes
Journal: Molecular Therapy (2004)

Congestive heart failure (CHF) remains a significant therapeutic challenge. Efficacious therapies are few, and the incidence of CHF and associated death rates continue to rise. Interest in gene therapy for CHF can be directed towards preserving cardiomyocyte structure and improving its function. Beneficial cardiac effects of growth hormone and insulin-like growth factor-1 (IGF-1) have been shown in heart failure in several settings, but studies are lacking on such forms of treatment in the cardiomyopathic heart.
Blocking Effect of the Migration-Inhibition Reaction by Sera From Immunized Syngeneic Mice and by Sera From Plasmacytoma-Bearing BALB/c Mice. Detection of Free, Circulating Tumor Antigen
Authors: Marie-France Poupon, Geneviève Lespinats, Jean-Pierre Kolb
Journal: JNCI Journal of the National Cancer Institute (1974)

A crude extract of BALB/c mouse plasmacytoma inhibited the migration of spleen cells from immunized BALB/c mice. Sera of tumor-bearing mice, even at a dilution of 1/100, and sera from immunized syngeneic mice blocked this inhibition. A mixture of the 2 types of sera had either a blocking effect or no effect on the migration inhibition, depending on the relative concentrations. Furthermore, sera from tumor-bearing animals directly provoked a migration inhibition of immune spleen cells without the addition of extraneous antigen. These results indicated that sera of plasmacytoma bearers contained free, circulating tumor-specific antigen.
Contrasting Effects of Maternal and Paternal Age on Offspring Intelligence
Authors: Mary Cannon
Journal: PLoS Medicine (2009)

Both maternal and paternal ages are increasing in the developed world. The average age of mothers at time of childbirth has increased from 26.4 years in 1974 to 29.3 years in 2002, while the average age of fathers has increased from 29.2 years in 1980 to 32.1 years in 2002 [1]. This increase in the average parental age is most likely due to the societal trend for couples to delay starting a family for career or financial reasons. The concept of the female “biological clock” (the effect of increasing maternal age on reducing fertility) is well known and is a source of anxiety for many women [2]. In contrast, the consequences of increasing paternal age on fertility and other adverse reproductive outcomes are rarely discussed [3].
THE RÔLE OF PREVENTIVE MEDICINE IN CLINICAL PRACTICE
Authors: W G SMILLIE
Journal: Annals of Internal Medicine (1948)

Article1 April 1948THE RÔLE OF PREVENTIVE MEDICINE IN CLINICAL PRACTICEWILSON G. SMILLIE, M.D.WILSON G. SMILLIE, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-28-4-826 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe text of this discussion—perhaps theorem is a better word—is that the internist of the next generation must concern himself primarily with the field of preventive medicine. This statement carries no implication that all physicians will soon be employed on Federal salary, or will be busy in the intricacies of public health administration.Let us make a clear distinction between public health and preventive medicine.Public healthis the obligation of the community to protect its members against the hazards of communal living, and to promote community-wide health. Thus public health is not a function of the internist, nor his... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: New York, N. Y.*Presented at the Twenty-Eighth Annual Session of the American College of Physicians, Chicago, April 28, 1947.From the Department of Public Health and Preventive Medicine, Cornell University Medical College, 1300 York Avenue, New York City. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byDIAGNOSTIC PROBLEMS OF RHEUMATIC FEVER AND THEIR IMPACT ON THE MANAGEMENT OF THE RHEUMATIC FEVER PATIENT*FREDERICK J. LEWY, M.D. 1 April 1948Volume 28, Issue 4Page: 826-832KeywordsPrevention, policy, and public healthPreventive medicine ePublished: 14 March 2020 Issue Published: 1 April 1948 PDF downloadLoading ...
Severe pulmonary hypertension in lung disease: phenotypes and response to treatment
Authors: Melanie J. Brewis, Alistair C. Church, Martin K. Johnson, Andrew J. Peacock
Journal: European Respiratory Journal (2015)

Pulmonary hypertension (PH) due to lung disease (World Health Organization (WHO) group 3) is common, but severe PH, arbitrarily defined as mean pulmonary artery pressure ≥35 mmHg is reported in only a small proportion. Whether these should be treated as patients in WHO group 1 (i.e. pulmonary arterial hypertension) with PH-targeted therapies is unknown. We compared the phenotypic characteristics and outcomes of 118 incident patients with severe PH and lung disease with 74 idiopathic pulmonary arterial hypertension (IPAH) patients, all treated with pulmonary vasodilators. Lung disease patients were older, more hypoxaemic, and had lower gas transfer, worse New York Heart Association functional class and lower 6-min walking distance (6MWD) than IPAH patients. Poorer survival in those with lung disease was driven by the interstitial lung disease (ILD) cohort. In contrast to IPAH, where significant improvements in 6MWD and N-terminal pro-brain natruiretic peptide (NT-proBNP) occurred, PH therapy in severe PH lung disease did not lead to improvement in 6MWD or functional class, but neither was deterioration seen. NT-proBNP decreased from 2200 to 1596 pg·mL(-1) (p=0.015). Response varied by lung disease phenotype, with poorer outcomes in patients with ILD and emphysema with preserved forced expiratory volume in 1 s. Further study is required to investigate whether vasodilator therapy may delay disease progression in severe PH with lung disease.
Acting and Clinical Empathy
Authors: Kenneth Haller
Journal: JAMA (2005)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
180. Use of Skeletal Muscle for Regulated Expression of Parathyroid Hormone To Treat Hypoparathyroidism
Authors: Maja Z. Salva, Jeffrey Bonadio, Stephen D. Hauschka
Journal: Molecular Therapy (2004)

Hypoparathyroidism is a condition in which reduction of serum calcium levels causes muscle cramps and spasms, and in extreme cases seizures and death. Current treatment for hypoparathyroidism involves daily oral supplements of the vitamin D analog calcitriol. This treatment is able to control some of the symptoms, including hypocalcemia and hyperphosphatemia, but the associated hypercalciurea remains poorly controlled, and if left untreated can lead to renal failure. Recent clinical studies showed that daily subcutaneous injections of recombinant hPTH1-34 normalized both serum and urine calcium levels in hypoparathyroid patients. Two daily injections achieved better control over calcium levels and required a lower daily dose (Winer et al, J Clin Endocrinol Metab. 2003, 88(9):4214–20). While these results suggest a new option for treating hypoparathyroidism, this approach requires the delivery of high PTH doses at each injection time to maintain adequate circulating levels, increasing the risk of side effects. More frequent administration of lower doses requires multiple daily injections, thus raising patient compliance issues. Both of these problems could be addressed via a gene therapy approach in which an externally regulated PTH expression cassette was transduced into skeletal muscle, and induced with a small orally available molecule. Careful dosing of the amount of transgene and the inducer molecule could then lead to production of therapeutic levels of circulating hormone.
Phase I trial of a ligand fusion-protein (DAB389IL-2) in lymphomas expressing the receptor for interkeukin-2
Authors: C. F. LeMaistre, Mansoor N. Saleh, Timothy M. Kuzel, Francine Foss, Leonidas C. Platanias, Gary Schwartz, Mark Ratain, Alain Rook, Cesar O. Freytes, Fiona Craig, James Reuben, Jean C. Nichols
Journal: Blood (1998)
Modifiable Behavioral Factors as Causes of Death
Authors: George Anstadt
Journal: JAMA (2004)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Abstract MP64: High Sodium Intake is Associated with Short Leukocyte Telomere Length in Overweight and Obese Adolescents
Authors: Haidong Zhu, Jigar Bhagatwala, Norman Pollock, Bernard Gutin, Jeffrey Thomas, Samip Parikh, Gregory Harshfield, Yanbin Dong
Journal: Circulation (2014)

Introduction: The aging process in children and adolescents is accelerated resulting in the premature development of “adult” diseases such as hypertension and diabetes. Telomere shortening plays a key role in human aging; identifying factors that regulate this process is important for developing effective lifestyle interventions so as to prevent and treat age-associated diseases. In vitro and in vivo studies demonstrate that high salt content markedly decreases life span, and accelerates cellular aging through increased DNA breakage. However, the effect of high salt diet on telomere length, a marker of biological aging, remains unknown. Therefore, we aimed to test the hypothesis that high dietary sodium intake is inversely associated with leukocyte telomere length, especially in the context of obesity. Methods: Leukocyte telomere length (T/S ratio) was assessed by a quantitative polymerase chain reaction method in 766 adolescents aged 14-18 years (50% female, 49% African Americans). Diet was assessed with three to seven 24-h recalls, and physical activity was determined by accelerometry. Participants were classified according to low vs. high sodium intake (below or above the median), and according to weight status (normal vs. overweight/obese). Analysis of covariance and linear regression analyses were used to determine the effects of sodium intake and weight status on leukocyte telomere length. Results: After controlling for age, sex, race, energy intake, Tanner stage, and vigorous physical activity, a statistically significant sodium intake by weight status interaction was observed, such that leukocyte telomere length was significantly shorter in the high sodium intake vs. low sodium intake subjects from the overweight/obese group (1.24 ± 0.22 vs. 1.32 ± 0.21, p=0.02), but not the normal weight group (1.29 ± 0.24 vs. 1.30 ± 0.24, p=0.69). Consistent with the low vs. high sodium intake group data, multiple linear regression analyses, adjusting for age, sex, race, energy intake, Tanner stage and vigorous physical activity, revealed that higher dietary sodium intake was associated with shorter leukocyte telomere length in the overweight/obese group (β=-0.37, p=.045), but not the normal weight group. Conclusion: High dietary sodium intake is associated with shorter telomere length in overweight and obese adolescents suggesting that high sodium intake and obesity may act synergistically to accelerate cellular aging. Longitudinal studies are warranted to determine the synergistic effect of high sodium intake and obesity on telomere shortening over time.
Mind the Gap
Authors: Alexander Turchin, Julian L. Seifter, Ellen W. Seely
Journal: New England Journal of Medicine (2003)

A 62-year-old woman with a history of acute myelogenous leukemia, who had undergone transplantation of T-cell–depleted allogeneic bone marrow two years earlier, was admitted to the hospital because of an elevated bilirubin level that was thought to be secondary to graft-versus-host disease. Her serum sodium level was 124 mmol per liter.