ERYTHROPHAGOCYTOSIS AND HEMOSIDEROSIS IN LYMPH NODES, SPLEEN AND LIVER IN PATIENTS DYING OF MALIGNANT HYPERTENSION, CHRONIC GLOMERULONEPHRITIS AND PYELONEPHRITIS AND POLYCYSTIC DISEASE
Authors: E E MUIRHEAD, W F SHIELDS
Journal: Annals of Internal Medicine (1954)

Article1 February 1954ERYTHROPHAGOCYTOSIS AND HEMOSIDEROSIS IN LYMPH NODES, SPLEEN AND LIVER IN PATIENTS DYING OF MALIGNANT HYPERTENSION, CHRONIC GLOMERULONEPHRITIS AND PYELONEPHRITIS AND POLYCYSTIC DISEASEE. E. MUIRHEAD, M.D., W. F. SHIELDS, M.D.E. E. MUIRHEAD, M.D.Search for more papers by this author, W. F. SHIELDS, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-40-2-307 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe occurrence of erythrophagocytosis and hemosiderosis in reticuloendothelial structures in association with the anemia of uremia of experimental animals1, 2, 3 suggested the need to determine whether such alterations occur in human tissues in association with bilateral renal disease causing renal failure and anemia. Such a study is reported below.SELECTION OF CASESTwenty-eight cases of uremia without selection were studied. Abdominal and thoracic lymph nodes, spleen and liver were examined microscopically after staining with hematoxylin and eosin and iron stains. The morphologic changes in lymph nodes, spleen and liver searched for included hemorrhages in the peripheral and medullary sinuses...Bibliography1. MuirheadJonesGrollman EEFA: The anemia of renal insufficiency as induced by bilateral nephrectomy of the rabbit: with emphasis on its hemolytic nature, J. Lab. and Clin. Med. 39: 505-517, 1952. MedlineGoogle Scholar2. MuirheadJonesStirmanLesch EEFJAW: Hemolytic anemia of the dog following bilateral nephrectomy, Am. J. Physiol. 173: 371-378, 1953. CrossrefMedlineGoogle Scholar3. MuirheadTurnerGrollman EELBA: Hypertensive cardiovascular disease: vascular lesions of dogs maintained for extended periods following bilateral nephrectomy or ureteral ligation, Arch. Path. 51: 575-592, 1951. Google Scholar4. SchwartzBlumenthal SOSA: Exogenous hemochromatosis resulting from blood transfusions, Blood 3: 617-640, 1948. CrossrefMedlineGoogle Scholar5. MuirheadCrassJonesHill EEGFJM: Iron overload (hemosiderosis) aggravated by blood transfusions, Arch. Int. Med. 83: 477-501, 1949. CrossrefGoogle Scholar6. Granick S: Iron metabolism and hemochromatosis, Bull. New York Acad. Med. 25: 403-428, 1949. MedlineGoogle Scholar7. FinchHagstedKinneyRathHoskinsFinchFluharty CAMTDCEDSRG: Iron metabolism: the pathophysiology of iron storage, Blood 5: 938-1008, 1950. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: *Received for publication June 24, 1953.From the Department of Pathology of the Southwestern Medical School of the University of Texas, Dallas, Texas, and Veterans Administration Hospital, McKinney, Texas.Supported by a grant from the U. S. Public Health Service.Reviewed in the Veterans Administration and published with the approval of the Chief Medical Director. The statements and conclusions published by the authors are the result of their own study and do not necessarily reflect the opinion or policy of the Veterans Administration. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byThe effect of acute uræmia upon the survival of skin homografts. Histological changes in the regional lymph-nodesHost Defenses and Immunologic Alterations Associated with Chronic HemodialysisSIMEON E. GOLDBLUM, M.D., WILLIAM P. REED, M.D.Lichtmikroskopische Untersuchungen über Veränderungen in den Sternzellen der Leber nach ErythrophagieThe kidney and erythropoiesisDie NiereninsuffizienzDie Pathologie des Stoffwechsels der Schwermetalle�ber die Siderinpigmente (unter besonderer Ber�cksichtigung ihrer Genese)Erythrophagocytosis and thrombocytopathy occurring during the course of a Henoch-Schönlein syndrome due to quinine 1 February 1954Volume 40, Issue 2Page: 307-312KeywordsAnemiaHypertensionLiverLymph nodesMedical servicesPyelonephritisRenal diseasesRenal failureSpleenStaining ePublished: 1 December 2008 Issue Published: 1 February 1954 PDF downloadLoading ...