Diabetic Ketoacidosis
Authors: Christine Laine
Journal: Annals of Internal Medicine (2010)

In the Clinic5 January 2010Diabetic KetoacidosisChristine Laine, MD, MPH, Sankey Williams, MD, Barbara J. Turner, MD, MSED, and Jennifer F. WilsonChristine Laine, MD, MPHSearch for more papers by this author, Sankey Williams, MDSearch for more papers by this author, Barbara J. Turner, MD, MSEDSearch for more papers by this author, and Jennifer F. WilsonSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-152-1-201001050-01001 SectionsSupplemental MaterialAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail Diabetic ketoacidosis (DKA), the complication of diabetes mellitus that causes the greatest risk for death, is characterized by hyperglycemia and metabolic acidosis due to the accumulation of ketones from the breakdown of free fatty acids. Treatment requires hospitalization to correct hyperglycemia as well as serious volume depletion and electrolyte abnormalities. DKA occurs primarily in patients with type 1 diabetes mellitus but can also occur in those with type 2 diabetes. In a multicenter study of nearly 15 000 children and adolescents, DKA was the initial presentation of type 1 diabetes for 21.1%, and this proportion did not change substantially from ...References1. Neu A, Hofer SE, Karges B, et al; DPV Initiative and the German BMBF Competency Network for Diabetes Mellitus. Ketoacidosis at diabetes onset is still frequent in children and adolescents: a multicenter analysis of 14,664 patients from 106 institutions. Diabetes Care. 2009;32:1647-8. [PMID:19549730] Google Scholar2. Wild S, Roglic G, Green A, et al. Global prevalence of diabetes: estimates for the year 2000 and projections for 2030. Diabetes Care. 2004;27:1047-53. [PMID:15111519] Google Scholar3. Henriksen OM, R¿der ME, Prahl JB, et al. 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[PMID:17360297] Google Scholar33. Maniatis AK, Goehrig SH, Gao D, et al. Increased incidence and severity of diabetic ketoacidosis among uninsured children with newly diagnosed type 1 diabetes mellitus. Pediatr Diabetes. 2005; 6: 79-83. [PMID:15963034] Google Scholar Author, Article, and Disclosure InformationAffiliations: PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byType 1 Diabetes MellitusFatima Z. Syed, MD, MScAcute Metabolic Emergencies in Diabetes: DKA, HHS and EDKAEndocrine Emergencies in the ICUA Portable Spectrophotometer-Based Breathalyzer for Point-of-Care Testing of Diabetic Patients 5 January 2010Volume 152, Issue 1Page: ITC1-1KeywordsBicarbonatesBloodGlucoseHyperglycemiaInsulinKetonesPotassiumType 1 diabetesType 2 diabetesUrine ePublished: 5 January 2010 Issue Published: 5 January 2010 Copyright & PermissionsCopyright © 2010 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...