The Ciguatera Poisoning Syndrome from Farm-Raised Salmon
Authors: M J DiNubile, Y Hokama
Journal: Annals of Internal Medicine (1995)

Brief Communications15 January 1995The Ciguatera Poisoning Syndrome from Farm-Raised SalmonMark J. DiNubile, MD and Yoshitsugi Hokama, MDMark J. DiNubile, MDFrom Cooper Hospital, University of Medicine and Dentistry of New Jersey/Robert Wood Johnson Medical School, Camden, New Jersey; and John A. Burns School of Medicine, University of Hawaii, Honolulu, Hawaii. and Yoshitsugi Hokama, MDFrom Cooper Hospital, University of Medicine and Dentistry of New Jersey/Robert Wood Johnson Medical School, Camden, New Jersey; and John A. Burns School of Medicine, University of Hawaii, Honolulu, Hawaii.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-122-2-199501150-00006 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail Ciguatera poisoning causes a distinct clinical syndrome characterized primarily by gastrointestinal and neurologic manifestations [1]. Although frequently unrecognized, ciguatera may be the most common type of fish poisoning in the United States [2-5]. Fish causing ciguatera poisoning are thought to be restricted to oceans within a 30-degree latitude on either side of the equator. Cold-water fish have almost never been associated with ciguatera poisoning [1-5].At least four distinct toxins can produce the clinical manifestations of ciguatera poisoning [1, 6, 7]. These toxins originate in dinoflagellates, and the toxins become more concentrated as they move up the food chain [1]. ...References1. Underman AE, Leedom JM. Fish and shellfish poisoning. Curr Clin Top Infect Dis. 1993; 13:203-25. Google Scholar2. Lawrence DN, Enriquez MB, Lumish RM, Maceo A. Ciguatera fish poisoning in Miami. JAMA. 1980; 244:254-8, 272-4. Google Scholar3. Morris PD, Campbell DS, Freeman JI. Ciguatera fish poisoning: an outbreak associated with fish caught from North Carolina coastal waters. South Med J. 1990; 83:379-82. Google Scholar4. Centers for Disease Control. Ciguatera fish poisoning-Vermont. MMWR Morb Mortal Wkly Rep. 1986; 35:263-4. Google Scholar5. DeFusco DJ, O'Dowd P, Hokama Y, Ott BR. Coma due to ciguatera poisoning in Rhode Island. Am J Med. 1993; 95:240-3. Google Scholar6. Scheuer PJ, Takahashi W, Tsutsumi J, Yoshida T. Ciguatoxin: isolation and chemical nature. Science. 1967; 155:1267-8. Google Scholar7. Kodama AM, Hokama Y, Yasumoto T, Fukaui M, Manea SJ, Sutherland N. Clinical and laboratory findings implicating palytoxin as a cause of ciguatera poisoning due to Decapterus macrosoma (mackerel). Toxicon. 1989; 27:1051-3. Google Scholar8. Hokama Y. Simplified solid-phase immunobead assay for detection of ciguatoxin and related polyethers. J Clin Lab Anal. 1990; 4:213-7. Google Scholar9. Kimura LH, Hokama Y, Abad MA, Oyama M, Miyahara JT. Comparison of three different assays for the assessment of ciguatoxin in fish tissues: radioimmunoassay, mouse bioassay and in vitro guinea pig atrium assay. Toxicon. 1982; 20:907-12. Google Scholar10. Miyahara JT, Akau OK, Yasumoto T. Effects of ciguatoxin and maitotoxin on the isolated guinea pig atrium. Res Commun Chem Pathol Pharmacol. 1979; 25:177-80. Google Scholar Author, Article, and Disclosure InformationAffiliations: From Cooper Hospital, University of Medicine and Dentistry of New Jersey/Robert Wood Johnson Medical School, Camden, New Jersey; and John A. Burns School of Medicine, University of Hawaii, Honolulu, Hawaii.Corresponding Author: Mark DiNubile, MD, Division of Infectious Diseases, Education and Research Building, Cooper Hospital/University Medical Center, 401 Haddon Avenue, Camden, NJ 08103. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited bySeafood intoxicationsPublic Health and EpidemiologyAn Updated Review of Ciguatera Fish Poisoning: Clinical, Epidemiological, Environmental, and Public Health ManagementNaturally Occurring Toxicants as Etiologic Agents of Foodborne DiseaseHarmful algal blooms and public healthDemyelinating Diseases of the Peripheral NervesBiological ProcessesNonbacterial Food PoisoningEmerging tropical diseases in Australia. Part 2. Ciguatera fish poisoningHaff Disease After Eating SalmonPoisoning and Toxic ExposureSeafood ToxidromesMarine neurotoxins: Ingestible toxinsChronic fatigue syndrome: chronic ciguatera poisoning as a differential diagnosisPOISONINGSArguments for a Role of Abnormal Ionophore Function in Chronic Fatigue SyndromeA case of ciguatera fish poisoningChronic CiguateraCiguatera poisoning after ingestion of imported jellyfish: diagnostic application of serum immunoassay 15 January 1995Volume 122, Issue 2Page: 113-114KeywordsCalcium channelsEatingFoodGuinea pigsIntoxicationMonoclonal antibodiesNauseaSodium channelsTasteToxins Issue Published: 15 January 1995 Copyright & PermissionsCopyright © 1995 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...