THE ROLE OF COUNTERCURRENT MECHANISMS IN URINE CONCENTRATION: A REVIEW
Authors: R W WINTERS, R E DAVIES
Journal: Annals of Internal Medicine (1961)

Review1 April 1961THE ROLE OF COUNTERCURRENT MECHANISMS IN URINE CONCENTRATION: A REVIEWROBERT W. WINTERS, M.D., ROBERT E. DAVIES, PH.D.ROBERT W. WINTERS, M.D.Search for more papers by this author, ROBERT E. DAVIES, PH.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-54-4-810 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptINTRODUCTIONWithin the past few years, there has been a remarkable advance in our understanding of the mechanism by which the kidney is able to produce a concentrated urine. The stimulus for this recent burst of progress has been the introduction into the field of a revolutionary new concept: that of the countercurrent osmotic multiplier. In this brief review, an attempt will be made to present the broad outlines of this new theory along with some explanation of its underlying physical principles and a summary of its major supporting evidence. No attempt will be made to treat the whole subject...Bibliography1. Peter K: Untersuchungen über bau und entwickelung der niere. I. Guastav Fischer, Jena, 1909. Google Scholar2. Crane MM: Observations of the function of the frog's kidney. Amer. J. Physiol. 81: 232, 1927. CrossrefGoogle Scholar3. BurgessHarveyMarshall WWAMEK: The site of the antidiuretic action of pituitary extract. J. Pharmacol. Exp. Ther. 49: 237, 1933. Google Scholar4. WalkerBottOliverMacDowell AMPAJMC: The collection and analysis of fluid from single nephrons of the mammalian kidney. Amer. J. Physiol. 134: 580, 1941. CrossrefGoogle Scholar5. WessonAnslowSmith LGWPHW: The excretion of strong electrolytes. Bull. N. Y. Acad. Med. 24: 586, 1948. MedlineGoogle Scholar6. Smith HW: The Kidney. 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Author, Article, and Disclosure InformationAffiliations: Philadelphia, Pa.*Received for publication December 8, 1960.From the Departments of Physiology and Biochemistry, University of Pennsylvania School of Medicine, Philadelphia, Pa.Requests for reprints should be addressed to Robert W. Winters, M.D., Depts. of Physiology and Biochemistry, University of Pennsylvania School of Medicine, Philadelphia 4, Pa. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byModelling and analysis of an endothermic reacting counter-current flowBlood urea nitrogen and serum creatinine1 Some Recently Introduced DrugsNiere und HerzinsuffizienzOn the nature of the renal concentrating defect in malnutritionUric Acid Nephropathy Complicating Acute Leukemia in ChildrenThe Counter Current System and Osmotic DiuresisWATER TRANSPORT AT CELL MEMBRANESRenal complications of neoplastic diseaseOxygen consumption and respiratory pigments of mitochondria of the inner medulla of the dog kidneyReversible defect in renal concentrating mechanism in patients with hypercalcemiaHypo- and HypernatremiaLOUIS G. WELT, M.D., F.A.C.P.Energy metabolism of the renal medulla 1 April 1961Volume 54, Issue 4Page: 810-826KeywordsAttentionBiochemistryKidneysRenal physiologyUrine ePublished: 1 December 2008 Issue Published: 1 April 1961 PDF downloadLoading ...