THE TREATMENT OF NARCOLEPSY WITH BENZEDRINE SULPHATE
Authors: Helmuth Ulrich, Carl E. Trapp, Ben Vidgoff
Journal: Annals of Internal Medicine (1936)

Article1 March 1936THE TREATMENT OF NARCOLEPSY WITH BENZEDRINE SULPHATEHELMUTH ULRICH, M.D., F.A.C.P., CARL E. TRAPP, M.D., BEN VIDGOFF, M.D.HELMUTH ULRICH, M.D., F.A.C.P.Search for more papers by this author, CARL E. TRAPP, M.D.Search for more papers by this author, BEN VIDGOFF, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-9-9-1213 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptInhalation of benzedrine (synthetic racemic benzyl-methyl carbinamine: C6H5CH2CHNH2CH31) for the relief of nasal congestion was found by one of us to be followed by sleeplessness, an experience that suggested the use of this method in the treatment of narcolepsy. Clinical trial showed, however, that inhalation of the drug produced very slight results, whereas oral medication was uniformly successful in preventing narcoleptic seizures. Six cases of narcolepsy have been treated by us and form the basis of this report. Prinzmetal and Bloomberg,2also, in a recent report published since the inception of our study, found oral treatment with benzedrine to give...Bibliography1. New and Non-Official Remedies, 1935. Google Scholar2. PRINZMETALBLOOMBERG MW: The use of benzedrine for the treatment of narcolepsy, Jr. Am. Med. Assoc., 1935, cv, 2051. CrossrefGoogle Scholar3. DANIELS LE: Narcolepsy, Medicine, 1934, xiii, 1. CrossrefGoogle Scholar4. TRÖMNER E: Narkolepsie (Schlafzwang), Zentralbl. f. d. ges. Neurol. u. Psychiat., 1929-30, liv, 326. Google Scholar5. ROSENTHAL C: Zur Pathogenese, Ätiologie und versorgungsrechlichen Bedeutung der "genuinen" und post-traumatischen echten Narkolepsie, Arch. f. Psychiat., 1932, xcvi, 572. CrossrefGoogle Scholar6. GOLDFLAM S: Zur Frage der genuinen Narkolepsie und ähnlichen Zustände, Deutsch. Ztschr. f. Nervenheilk., 1924, lxxxii, 20. CrossrefGoogle Scholar7. GRÜN R: Beitrag zur Kenntnis der Narkolepsie und der Frage der Dienstbeschädigung bei dieser Krankheit, Ztschr. f. d. ges. Neurol. u. Psychiat., 1931, cxxxiv, 155. CrossrefGoogle Scholar8. BEYERMANN : Über pathologische Schlafzustände, insbesonders narkoleptische Anfälle, in ihrem Zusammenhange mit Funktionsstörungen der Hypophyse, Ztschr. f. d. ges. Neurol. u. Psychiat., 1930, cxxviii, 726. CrossrefGoogle Scholar9. REDLICH E: Die Gelineausche Narkolepsie, Med. Welt, 1927, i, 1281. Google Scholar10. THIELEBERNHARDT RN: Erfahrungen über Narkolepsie, Zentralbl. f. d. ges. Neurol. u. Psychiat., 1931, lxi, 143. Google Scholar11. JANOTA O: Symptomatische Behandlung der pathologischen Schlafsucht, besonders der Narkolepsie, Med. Klin., 1931, xxvii, 278. Google Scholar12. ALLES GA: The comparative physiologic actions of the di-phenylisopropylamines: I. Pressor effect, Jr. Pharmacol. and Exper. Therap., 1933, xlvii, 339. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Boston, Massachusetts*Received for publication January 8, 1936.From the Evans Memorial of the Massachusetts Memorial Hospitals, Boston, Mass.†For a detailed discussion and comprehensive bibliography of narcolepsy the reader is referred to Daniels' excellent thesis.3 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byAmphetamine Dependence; Clinical FeaturesÜber außermedizinische Verwendung der Weckamine und das Problem der LeistungssteigerungStudien über die Wirkung vonβ-Phenyl-Isopropylaminsulfat (Mecodrin) auf Normale MenschenThe Effect of Benzedrine Sulfate ( Benzyl Methyl Carbinamine ) Upon the Report of Boredom and Other Factors 1 March 1936Volume 9, Issue 9Page: 1213-1221KeywordsClinical trialsDrugsEpileptic seizuresInhalationNarcolepsy ePublished: 1 December 2008 Issue Published: 1 March 1936 PDF downloadLoading ...