Zidovudine and Nephropathy with Human Immunodeficiency Virus (HIV) Infection
Authors: Marie-Laure Babut-Gay, Marie Echard, Dieter Kleinknecht, Alain Meyrier
Journal: Annals of Internal Medicine (1989)

Letters and Corrections15 November 1989Zidovudine and Nephropathy with Human Immunodeficiency Virus (HIV) InfectionMarie-Laure Babut-Gay, MD, Marie Echard, MD, Dieter Kleinknecht, MD, Alain Meyrier, MDMarie-Laure Babut-Gay, MDSearch for more papers by this author, Marie Echard, MDSearch for more papers by this author, Dieter Kleinknecht, MDSearch for more papers by this author, Alain Meyrier, MDSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-111-10-856_2 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the Editor: Human immunodeficiency virus (HIV)-associated nephropathy usually manifests as the nephrotic syndrome with glomerular lesions of focal and segmental glomerulosclerosis. The disease rapidly progresses to end-stage renal failure in months or even weeks. Such unusually rapid progression of HIV-related focal and segmental glomerulosclerosis has mainly been observed in drug addicts and in blacks (1, 2). No reports are available concerning the influence of zidovudine (AZT) treatment on the course of HIV-associated nephropathy. We present a case of focal and segmental glomerulosclerosis in which zidovudine appeared to induce an 11-month remission of the nephrotic syndrome.A 34-year-old bisexual man...References1. RaoFriedmanNicastri TEA. Associated focal and segmental glomerulosclerosis in AIDS. N Engl J Med. 1984;310:669-73. CrossrefMedlineGoogle Scholar2. CarboneD'AgatiAppel LVG. HTLV-III associated nephropathy: life table analysis [Abstract]. Kidney Int. 1987;31:193. Google Scholar3. BaumelouAssogbaBeaufils AUH. Pathologie rénale associée à l'infection à virus HIV et au syndrome d'immunodéficience acquise. In: Chatelain C, Jacobs C. Séminaires d'Uro-Néphrologie. Paris:Masson;1989:42-9. Google Scholar4. RaoMallisFriedman TLE. Nephropathy as the initial manifestation of human immunodeficiency virus disease [Abstract]. Kidney Int. 1988;33:205. Google Scholar5. DournonMatheronRozenbaum ESW. Effects of zidovudine in 365 consecutive patients with AIDS or ARC. Lancet. 1988;2:1297-1302. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByKDIGO 2021 Clinical Practice Guideline for the Management of Glomerular DiseasesGlomerular Diseases Associated with HIV, Hepatitis B, and Hepatitis C InfectionsChapter 9: Infection-related glomerulonephritisReferencesTreatment of HIV-Associated NephropathiesSuppression of HIV-1 replication by antiretroviral therapy improves renal function in persons with low CD4 cell counts and chronic kidney diseaseHIV and direct damage of organsHIV-associated nephropathy: Epidemiology, pathogenesis, and treatmentHUMAN IMMUNODEFICIENCY VIRUS INFECTION AND RENAL FAILURERenal Diseases Associated with Human Immunodeficiency Virus Infection: Epidemiology, Clinical Course, and ManagementTreatment of HIV-Associated NephropathyCohort study of the treatment of severe HIV-associated nephropathy with corticosteroidsRenal Complications of Intravenous Drug Abuse and Human Immunodeficiency Virus InfectionClinical response to prolonged corticosteroids in a patient with human immunodeficiency virus-associated nephropathyClinicopathologic correlates of prednisone treatment of human immunodeficiency virus-associated nephropathyCaptopril and renal survival in patients with human immunodeficiency virus nephropathyPrednisone Improves Renal Function and Proteinuria in Human Immunodeficiency Virus-associated NephropathyHuman immunodeficiency virus-associated glomerulosclerosisEffect of corticosteroid therapy on human immunodeficiency virus-associated nephropathyHuman Immunodeficiency Virus-Associated Nephropathy: Current ConceptsVirus-Related Acute Renal Failure: The Clinical Course and Outcome of Hemorrhagic Fever with Renal SyndromeHuman Immunodeficiency Virus Infection and Nephrotic SyndromeA Steroid-Responsive Nephrotic Syndrome in a Patient with Human Immunodeficiency Virus (HIV) InfectionRichard G. Appel, MD, James Neill, MDAcquired Immunodeficiency Syndrome (AIDS), Human Immunodeficiency Virus (HIV) Infection, and Dialysis 15 November 1989Volume 111, Issue 10Page: 856-857KeywordsAddictsBisexualsHIVHIV infectionsLesionsRenal failure Issue Published: 15 November 1989 PDF DownloadLoading ...