tbuckley/cabot-search huggingface dataset:
Drugs and the Public Safety
Authors: JOSEPH F. SADUSK
Journal: Annals of Internal Medicine (1966)

Special Article1 October 1966Drugs and the Public SafetyJOSEPH F. SADUSK JR., M.D., F.A.C.P.JOSEPH F. SADUSK JR., M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-65-4-849 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptDuring the past 2 years when I held the position of Medical Director of the Food and Drug Administration, I had the privilege of working with a group of highly dedicated public servants, both medical and nonmedical, both scientific and regulatory. I was most impressed with the substantial contributions that these devoted persons have made in the public interest, and I should like to pay tribute to my former colleagues. I should like also to personally acknowledge the skillful leadership and guidance which Commissioner Emeritus George Larrick gave to the Administration during the critical interim period of early implementation of...References1. REMINGTON JP: The Practice of Pharmacy, 4th ed. J. B. Lippincott Co., Philadelphia, 1905. Google Scholar2. SADUSK JF: The definition of the efficacy of a drug under the law. Bull. Amer. Col. Physicians 5: 328, 1964. Google Scholar3. CARROLLBRYANROBINSON OMPARJ: Stevens-Johnson syndrome associated with long acting sulfonamides. JAMA 195: 691, 1966. CrossrefMedlineGoogle Scholar4. World Health Organization: Clinical aspects of oral gestogens. Technical Report Series no. 326, World Health Organization, Geneva, 1966. Google Scholar5. DUNLOP D: Use and abuse of drugs. Brit. Med. J. 2: 437, 1965. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: From the Department of Preventive Medicine and Community Health, the George Washington University School of Medicine, Washington, D. C.This paper was presented in the Second Plenary Session, 47th Annual Session of the American College of Physicians, New York, N. Y., April 19, 1966.Requests for reprints should be addressed to Joseph F. Sadusk, Jr., M.D., Johns Hopkins Hospital, 601 N. Broadway, Baltimore, Md. 21205. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 October 1966Volume 65, Issue 4Page: 849-856KeywordsDrug safetyDrugsFood and Drug AdministrationPrevention, policy, and public healthPreventive medicine Issue Published: 1 October 1966 PDF DownloadLoading ...
Extensive retinal haemorrhages in infancy--an innocent cause.
Authors: C J Bacon, G C Sayer, J W Howe
Journal: BMJ (1978)

there was a significant rise in the Paco2 (P<0 001) in ten patients (table) but no significant change in the other two values.Mean plasma cholesterol concentration was 5 6 mmol/l (range 2-6-7 7) (216 mg/100 ml (100-297))(normal 4-8 mmol/I (154-308 mg/100 ml)) while the mean plasma cortisol concentration in the 13 patients studied was 472 nmol/l (range 110-1090) (17 ttg/100 ml (range 3-39)).Normal at 0900 was 280-690 nmol/l (10-25 ,ug/l).The routine biochemical and haematological tests showed no unex- plained abnormalities.
Mr Nice Guy
Authors: G. Watts
Journal: BMJ (2003)

What does running a police force have in common with enhancing standards in the medical profession? Plenty, says Sandy Forrest , first head of the Council for the Regulation of Healthcare Professionals

Although doctors do not see the General Medical Council as a body that is “on their side,” outsiders have complained for years that it smacks of an “old boys' club” that fails to put patients first.

Such was the thinking behind the Kennedy report into heart surgery at Bristol Royal Infirmary, which recommended the establishment of an overarching body to regulate all the health professions ( BMJ 2001 ;323: 181). The new council would send a message to doctors that if they wanted to retain self regulation, the GMC would have to become part of a larger organisation, which could keep an eye on it.

Now the new body–the Council for the Regulation of Healthcare Professionals–is in place and its director is due to take up his post in two weeks' time. Appropriately, many would say, the director turns out to be a serving police officer.

Until he takes over full time in mid-November, Sandy Forrest, aged 50, is Her Majesty's assistant inspector of constabulary for Scotland. Appointing someone with this background to oversee the regulation of the health professions could be seen …
Insulin action on heart and skeletal muscle glucose uptake in essential hypertension.
Authors: P Nuutila, M Mäki, H Laine, M J Knuuti, U Ruotsalainen, M Luotolahti, M Haaparanta, O Solin, A Jula, V A Koivisto
Journal: Journal of Clinical Investigation (1995)

Essential hypertension is characterized by skeletal muscle insulin resistance but it is unknown whether insulin resistance also affects heart glucose uptake. We quantitated whole body (euglycemic insulin clamp) and heart and skeletal muscle (positron emission tomography and 18F-fluoro-2-deoxy-D-glucose) glucose uptake rates in 10 mild essential hypertensive (age 33 +/- 1 yr, body mass index 23.7 +/- 0.8 kg/m2, blood pressure 146 +/- 3/97 +/- 3 mmHg, VO2max 37 +/- 3 ml/kg per min) and 14 normal subjects (29 +/- 2 yr, 22.5 +/- 0.5 kg/m2, 118 +/- 4/69 +/- 3 mmHg, 43 +/- 2 ml/kg per min). Left ventricular mass was similar in the hypertensive (155 +/- 15 g) and the normotensive (164 +/- 13 g) subjects. In the hypertensives, both whole body (28 +/- 3 vs 44 +/- 3 mumol/kg per min, P < 0.01) and femoral (64 +/- 11 vs 94 +/- 8 mumol/kg muscle per min, P < 0.05) glucose uptake rates were decreased compared to the controls. In contrast, heart glucose uptake was 33% increased in the hypertensives (939 +/- 51 vs 707 +/- 46 mumol/kg muscle per min, P < 0.005), and correlated with systolic blood pressure (r = 0.66, P < 0.001) and the minute work index (r = 0.48, P < 0.05). We conclude that insulin-stimulated glucose uptake is decreased in skeletal muscle but increased in proportion to cardiac work in essential hypertension. The increase in heart glucose uptake in mild essential hypertensives with a normal left ventricular mass may reflect increased oxygen consumption and represent an early signal which precedes the development of left ventricular hypertrophy.
A QRS Scoring System for Assessing Left Ventricular Function after Myocardial Infarction
Authors: Sebastian T. Palmeri, David G. Harrison, Frederick R. Cobb, Kenneth G. Morris, Frank E. Harrell, Raymond E. Ideker, Ronald H. Selvester, Galen S. Wagner
Journal: New England Journal of Medicine (1982)

A QRS scoring system for estimating the size of a myocardial infarct was evaluated in 55 patients who did not have left ventricular hypertrophy or conduction abnormalities. Serial 12-lead surface electrocardiograms were scored according to a 29-point system based on the duration of Q and R waves and on the ratios of R-to-Q amplitude and R-to-S amplitude. The scores were proportional to the severity of wall-motion abnormalities, which was determined by radionuclide blood-pool scanning and which correlated inversely with the radionuclide-determined left ventricular ejection fraction (LVEF). A score less than 3 was 93 per cent sensitive and 88 per cent specific for both severe regional dyssynergy and major depression of the global LVEF. The following equation was used to estimate the LVEF from the QRS score: LVEF (%) = 60 - (3 x QRS score). After acute myocardial infarction, an electrocardiogram can provide important indirect quantitative information about left ventricular function.
A quarter of patients with cancer see their GP several times before being referred
Authors: S. Mayor
Journal: BMJ (2011)

Three quarters of patients who see their GP with symptoms that lead to a cancer diagnosis are referred extremely promptly—within one or two visits—but a quarter had three or more consultations before they were referred to a specialist, shows an audit of general practices. About 3% saw their GP five times or more before being referred.

GPs were best are spotting cancers with obvious symptoms. Nearly three quarters (72%) of patients who were given a diagnosis of breast cancer were referred after seeing their GP just once, as were 69% of patients with melanoma, 62% with endometrial cancer, and 61% with testicular cancer, shows the audit, which was carried out by the Royal College of …
The Allergic Airway Inflammation Repository - a user-friendly, curated resource of mRNA expression levels in studies of allergic airways
Authors: D. R. Gawel, A. Rani James, M. Benson, R. Liljenström, A. Muraro, C. E. Nestor, H. Zhang, M. Gustafsson
Journal: Allergy (2014)

Public microarray databases allow analysis of expression levels of candidate genes in different contexts. However, finding relevant microarray data is complicated by the large number of available studies. We have compiled a user-friendly, open-access database of mRNA microarray experiments relevant to allergic airway inflammation, the Allergic Airway Inflammation Repository (AAIR, http://aair.cimed.ike.liu.se/). The aim is to allow allergy researchers to determine the expression profile of their genes of interest in multiple clinical data sets and several experimental systems quickly and intuitively. AAIR also provides quick links to other relevant information such as experimental protocols, related literature and raw data files.
Myocardial function in areas of heterogeneous perfusion after coronary artery occlusion in conscious dogs.
Authors: D A Cox, S F Vatner
Journal: Circulation (1982)

Regional myocardial function and blood flow in endocardial layers were correlated in myocardial segments subtending severely ischemic and adjacent, normally perfused myocardium in conscious dogs 1--3 weeks after recovery from coronary artery occlusion. With coronary artery occlusion induced by a hydraulic occluder, endocardial blood flow (measured with radioactive microspheres) and function (determined with an ultrasonic dimension gauge) in homogeneously nonischemic segments increased slightly but not significantly. In homogeneously ischemic segments, blood flow and function decreased (p less than 0.01) by 96 +/- 1% and 98 +/- 4%, respectively. In segments subtending zones of unequal perfusion, endocardial blood flow increased nonsignificantly in the myocardium surrounding the nonischemic crystal, while decreasing by 93 +/- 2% (p less than 0.01) in myocardium surrounding the ischemic crystal. Surprisingly, these segments behaved like homogeneously ischemic segments, i.e., endocardial shortening decreased by 92 +/- 6% (p less than 0.01). Thus, the failure to detect shortening despite normal perfusion of the myocardium surrounding one of the transducers suggest a potential problem with interpretation of regional function measurements or an inability of the apparently nonischemic myocardium to contract.
Preferences for chemotherapy in patients with advanced non-small cell lung cancer: descriptive study based on scripted interviews
Authors: G. Silvestri, R. Pritchard, H G. Welch
Journal: BMJ (1998)

<h3>Introduction</h3> Despite evidence of health inequalities for adults with intellectual disability (ID) there has yet to be a comprehensive review of how well hospital services are meeting the needs of children and young people (CYP) with ID and their families. We do not know how relevant existing recommendations and guidelines are to CYP, whether these are being applied in the paediatric setting or what difference they are making. Evidence of parental dissatisfaction with the quality, safety and accessibility of hospital care for CYP with ID exists. However, the extent to which their experience differs from parents of CYP without ID is not known and the views and experiences of CYP with ID have not been investigated. We will compare how services are delivered to, and experienced by CYP aged 5–15 years with and without ID and their families to see what inequalities exist, for whom, why and under what circumstances. <h3>Methods and analysis</h3> We will use a transformative, mixed methods case study design to collect data over four consecutive phases. We will involve CYP, parents and hospital staff using a range of methods; interviews, parental electronic diary, hospital and community staff questionnaire, patient and parent satisfaction questionnaire, content analysis of hospital documents and a retrospective mapping of patient hospital activity. Qualitative data will be managed and analysed using NVivo and quantitative data will be analysed using parametric and non-parametric descriptive statistics. <h3>Ethics and dissemination</h3> The study will run from December 2015 to November 2018. We have Health Authority Approval (IRAS project ID: 193932) for phase 1 involving staff only and ethical and Health Authority Approval for phases 2–4 (IRAS project ID: 178525). We will disseminate widely to relevant stakeholders, using a range of accessible formats, including social media. We will publish in international peer-reviewed journals and present to professional, academic and lay audiences through national and international conferences.
Ultrafiltration Studies on Serum Magnesium
Authors: Samuel H. Silverman, Lytt I. Gardner
Journal: New England Journal of Medicine (1954)

OF the four major cations in human extracellular fluid, magnesium has been investigated least. This neglect may be attributed in part to difficulties in methodology, since serum contains only 1 or 2 milliequiv. of magnesium per liter. The magnesium ion, however, is a large component of intracellular fluid and bone. Numerous animal studies have demonstrated its dietary importance in intermediary metabolism.1 2 3 4 Low concentrations of serum magnesium have been reported in patients with rickets caused by vitamin D deficiency,5 diabetic ketosis during insulin therapy,6 and dietary phosphate load7 , 8 and in a child with chronic tremor and a bony lesion thought to . . .
AJCC Cancer Staging Manual
Authors: James R. Egner
Journal: JAMA (2010)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The skin-gut relationship in dermatitis herpetiformis
Authors: Janet Marks, Sam Shuster, Sandra Young, R.H. Felix, A.J. Watson
Journal: British Journal of Dermatology (1974)

Journal Article The skin‐gut relationship in dermatitis herpetiformis Get access Janet Marks, Janet Marks University Departments of Dermatology and Pathology, Royal Victoria Infirmary, Newcastle‐upon‐Tyne Search for other works by this author on: Oxford Academic Google Scholar Sam Shuster, Sam Shuster University Departments of Dermatology and Pathology, Royal Victoria Infirmary, Newcastle‐upon‐Tyne Search for other works by this author on: Oxford Academic Google Scholar Sandra Young, Sandra Young University Departments of Dermatology and Pathology, Royal Victoria Infirmary, Newcastle‐upon‐Tyne Search for other works by this author on: Oxford Academic Google Scholar R.H. Felix, R.H. Felix University Departments of Dermatology and Pathology, Royal Victoria Infirmary, Newcastle‐upon‐Tyne Search for other works by this author on: Oxford Academic Google Scholar A.J. Watson A.J. Watson University Departments of Dermatology and Pathology, Royal Victoria Infirmary, Newcastle‐upon‐Tyne Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 91, Issue s10, 1 July 1974, Pages 34–35, https://doi.org/10.1111/j.1365-2133.1974.tb12500.x Published: 01 July 1974
Differential Perfusion Hypothermia
Authors: James M. Lee
Journal: JAMA (1962)

THE LIMITING FACTOR in the treatment of malignant tumors with high doses of chemotherapeutic agents has proved to be depression of the hematopoietic system. It has been shown, however, that hypothermia protects the bone marrow from these depressive effects of the alkylating agents. This experimental study was designed to determine the feasibility of selective protection of the bone marrow in the lower half of the body by differential pelvic perfusion hypothermia. The basic idea of this technique is to permit systemic administration of relatively high doses of cancerocidal agents, thereby subjecting a tumor-bearing area in tbe upper half of the body to high drug levels at a normal temperature, while protecting the hematopoietic system in the lower body by hypothermia. Methods Differential pelvic perfusion hypothermia was accomplished as follows: Dogs weighing 10 to 18 kg. (22 to 40 lb.) were anesthetized with pentobarbital (Nembutal), intubated, and artificially respirated. After giving
Serum Interleukin-18 Levels Are Increased and Closely Associated With Various Soluble Adhesion Molecule Levels in Type 1 Diabetic Patients
Authors: Naoto Katakami, Hideaki Kaneto, Munehide Matsuhisa, Kazutomi Yoshiuchi, Ken Kato, Kaoru Yamamoto, Yutaka Umayahara, Keisuke Kosugi, Masatsugu Hori, Yoshimitsu Yamasaki
Journal: Diabetes Care (2006)

Recent studies have shown that low-grade inflammation plays an important role in the development of diabetes vascular complications (1). Interleukin-18 (IL-18) is well known to play a key role in various inflammatory and autoimmune diseases (2). IL-18 produces proinflammatory cytokines and upregulates various adhesion molecule expression (3,4). These processes could lead to the development of diabetes vascular complications including atherosclerosis. Indeed, serum IL-18 levels can be a strong predictor of death in patients with cardiovascular diseases (5,6) and is associated with nephropathy and atherosclerosis in type 2 diabetic patients (7).

It was also reported (8) that serum IL-18 levels were increased during the early developing stage of type 1 diabetes, but we cannot exclude the possibility that these results were simply influenced by inflammation at the onset of type 1 diabetes. In this study, we examined serum IL-18 levels in the chronic stage of type 1 diabetes and the possible association between serum IL-18 and various soluble adhesion molecule levels.

A total of 77 Japanese type 1 diabetic patients (25 men and 52 women, mean ± SD age 23.3 ± 4.4 years, duration of diabetes 13.2 ± …
Sorcin Induces a Drug-Resistant Phenotype in Human Colorectal Cancer by Modulating Ca2+ Homeostasis
Authors: Francesca Maddalena, Gabriella Laudiero, Annamaria Piscazzi, Agnese Secondo, Antonella Scorziello, Valentina Lombardi, Danilo Swann Matassa, Alberto Fersini, Vincenzo Neri, Franca Esposito, Matteo Landriscina
Journal: Cancer Research (2011)

Abstract The Ca2+-binding protein sorcin regulates intracellular calcium homeostasis and plays a role in the induction of drug resistance in human cancers. Recently, an 18 kDa mitochondrial isoform of sorcin was reported to participate in antiapoptosis in human colorectal cancer (CRC), but information remains lacking about the functional role of the more abundant 22 kDa isoform of sorcin expressed in CRC. We found the 22 kDa isoform to be widely expressed in human CRC cells, whether or not they were drug resistant. Its upregulation in drug-sensitive cells induced resistance to 5-fluorouracil, oxaliplatin, and irinotecan, whereas its downregulation sensitized CRC cells to these chemotherapeutic agents. Sorcin enhances the accumulation of Ca2+ in the endoplasmic reticulum (ER), preventing ER stress, and, in support of this function, we found that the 22 kDa isoform of sorcin was upregulated under conditions of ER stress. In contrast, RNAi-mediated silencing of sorcin activated caspase-3, caspase-12, and GRP78/BiP, triggering apoptosis through the mitochondrial pathway. Our findings establish that CRC cells overexpress sorcin as an adaptive mechanism to prevent ER stress and escape apoptosis triggered by chemotherapeutic agents, prompting its further investigation as a novel molecular target to overcome MDR. Cancer Res; 71(24); 7659–69. ©2011 AACR.
Propranolol Withdrawal and Variceal Hemorrhage
Authors: Steven L. Alabaster
Journal: JAMA (1983)

<h3>To the Editor.—</h3> The suggestion that propranolol hydrochloride would be useful in preventing recurrent variceal hemorrhage has been supported by several control trials.<sup>1-3</sup>In addition, Lebrec et al<sup>4</sup>and Maringhini et al<sup>5</sup>have reported that patients receiving propranolol for prophylaxis of recurrent variceal hemorrhage may rebleed if propranolol therapy is suddenly discontinued. We report our experience with a cirrhotic patient who had no previous hemorrhage until use of the propranolol he was taking to control systemic hypertension was suddenly discontinued. <h3>Report of a Case.—</h3> A 59-year-old man with chronic alcoholism was admitted to the Albuquerque Veterans Administration Medical Center for an episode of hematemesis, preceded by four days of melena. A liver biopsy obtained four years previously showed micronodular cirrhosis. He also had systemic hypertension suboptimally controlled with propranolol hydrochloride, 80 mg/day for two years, but use of this was discontinued abruptly four days before the onset
1165-106 Outpatient clinic base therapeutic program of exercise after heparin administration for patients with arteriosclerosis obliterans
Authors: Takanori Yasu, Taishi Hirahara, Yasuhiro Maejima, Hiroto Ueba, Nahoko Ikeda, Akihiro Kakehashi, Masatoshi Kuroki, Masanobu Kawakami, Muneyasu Saito
Journal: Journal of the American College of Cardiology (2004)
Pityriasis rosea-like eruption in a patient receiving omeprazolc syndrome
Authors: C. Buckley
Journal: British Journal of Dermatology (1996)

Journal Article Pityriasis rosea‐like eruption in a patient receiving omeprazolc syndrome Get access C. Buckley C. Buckley Department of Dermatology. Dorset County Hospital. Princes Street. Dorchester. Dorset DTI ITS.U.K. Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 135, Issue 4, 1 October 1996, Pages 660–661, https://doi.org/10.1111/j.1365-2133.1996.tb03863.x Published: 01 October 1996