tbuckley/cabot-search huggingface dataset:
NORMAL KIDNEYS AND RETINAE AFTER 35 YEARS OF DIABETES
Authors: K M WEST
Journal: Annals of Internal Medicine (1957)

Case Reports1 December 1957NORMAL KIDNEYS AND RETINAE AFTER 35 YEARS OF DIABETESKELLY M. WEST, M.D.KELLY M. WEST, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-47-6-1256 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptAt present the overwhelming majority of deaths in patients with diabetes mellitus is attributable to degenerative vascular lesions, the control of which is the most important problem facing those who treat diabetics. In order to evaluate measures aimed at the postponement or avoidance of such lesions, it will be necessary to accumulate more experience concerning the natural history of long-term diabetes under various methods of treatment.Retinopathy and nephropathy have been regarded by some as the inevitable accompaniment of diabetes of substantial duration. Dolger1had the unfortunate experience of finding in a group of 200 long-duration cases not a single...Bibliography1. Dolger H: Clinical evaluation of vascular damage in diabetes, J. A. M. A. 134: 1289-1291, 1947. CrossrefMedlineGoogle Scholar2. LarssonLichtensteinPloman YAKG: Degenerative vascular lesions in juvenile diabetes mellitus, Diabetes 1: 449-458, 1952. CrossrefMedlineGoogle Scholar3. Joslin EP: Editorial, J. A. M. A. 156: 1584-1585, 1954. CrossrefMedlineGoogle Scholar4. RootBarclay HFP: Diabetes of thirty-five years' duration, J. A. M. A. 161: 801-806, 1956. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Oklahoma City, Oklahoma*Received for publication December 30, 1955.From the Department of Medicine, University of Oklahoma School of Medicine, and the Oklahoma City Veterans Administration Hospital.Requests for reprints should be addressed to Kelly M. West, M.D., Department of Medicine, The University of Oklahoma School of Medicine, 800 Northeast Thirteenth Street, Oklahoma City 4, Oklahoma. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byRENAL GLOMERULAR AND VASCULAR LESIONS IN PREDIABETES AND IN DIABETES MELLITUS: A STUDY BASED ON RENAL BIOPSIES*†ALBERTO DAYSOG JR., M.D., HAROLD L. DOBSON, M.D., JAMES C. BRENNAN, M.D. 1 December 1957Volume 47, Issue 6Page: 1256-1259KeywordsAutopsyDiabetes mellitusElectrocardiographyHemorrhageHospital medicineInsulinKidneysLesionsRetinaRetinopathy ePublished: 1 December 2008 Issue Published: 1 December 1957 PDF downloadLoading ...
BRAIN WATER MEASURED BY MAGNETIC RESONANCE IMAGING
Authors: B.A. Bell, D.M. Kean, H.L. Macdonald, G.H. Barnett, R.H.B. Douglas, M.A. Smith, C.N.J. Mcghee, J.D. Miller, J.L. Tocher, J.J.K. Best
Journal: The Lancet (1987)
Vaccines and medicines for the world's poorest
Authors: R. Smith
Journal: BMJ (2000)

Three million children die every year in poor countries from diseases that can be prevented by vaccination.1 Millions more die from diseases—like malaria and AIDS—that should be preventable by vaccines if they were developed. Unfortunately existing vaccines are not reaching these children because of failures in delivery systems, lack of resources, and the high price of some newer vaccines. Moreover, new vaccines may not be developed because private companies can't foresee a good return. The same story of huge need and market failure applies to drugs: of 1223 drugs developed between 1975 and 1997 only 11 were for tropical conditions.2

The problems seem huge. Yet there was an upbeat end to a meeting on the problem in Carmel, California, last month organised by the Institute of Global Health and the Global Forum for Health Research. The issue is rising up political agendas around the world, and new public-private partnerships are being devised to increase access to vaccines and drugs and develop new ones. Reducing deaths from communicable diseases would be a rich prize because these account for three quarters of the mortality gap between the rich and the poor world.1

Although the meeting ended optimistically, …
ABO Blood Group Antigens on Human Plasma von Willebrand Factor After ABO-Mismatched Bone Marrow Transplantation
Authors: Taei Matsui, Taketo Shimoyama, Masanori Matsumoto, Yoshihiro Fujimura, Yoshinobu Takemoto, Masahiro Sako, Jiharu Hamako, Koiti Titani
Journal: Blood (1999)
Duodenal Perforation by an Infusion Catheter for Hepatic Chemotherapy
Authors: MARCOS A. SOUZA LIMA
Journal: Annals of Internal Medicine (1985)

Letters and Corrections1 September 1985Duodenal Perforation by an Infusion Catheter for Hepatic ChemotherapyMARCOS A. SOUZA LIMA, M.D., GEORGE M. MATTHEW, M.D., BERGON F. BROKAW, M.D., HUX ROBERT H., M.D.MARCOS A. SOUZA LIMA, M.D.Search for more papers by this author, GEORGE M. MATTHEW, M.D.Search for more papers by this author, BERGON F. BROKAW, M.D.Search for more papers by this author, HUX ROBERT H., M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-103-3-472_1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: An implantable and percutaneously refillable pump (Infusaid; Infusaid Corp., Norwood, Massachusetts) has been approved recently by the Food and Drug Administration for continuous intravascular drug infusion. Symptomatic gastritis or ulcer have been reported in 16% of patients after pump placement for hepatic-arterial chemotherapy (1). We report the case of a patient with duodenal ulcer with perforation caused by the infusion catheter.A 78-year-old white man with metastatic liver disease had a pump implanted by standard technique (2) for regional chemotherapy on 4 December 1984. He was hospitalized 5 months later with tarry stools and weakness. The patient...References1. COHENKAUFMANWOODGREENFIELD ASWA. Regional hepatic chemotherapy using an implantable drug infusion pump. Am J Surg. 1983;145:529-33. CrossrefMedlineGoogle Scholar2. NIEDERHUBERENSMINGER JW. Surgical considerations in the management of hepatic neoplasia. Semin Oncol. 1983;10:135-47. MedlineGoogle Scholar3. BALCHURISTSOONGMCGREGOR CMSM. A prospective phase-II clinical trial of continuous FUDR regional chemotherapy for colorectal metastases to the liver using a totally implantable drug infusion pump. Ann Surg. 1983;198:567-73. CrossrefMedlineGoogle Scholar4. NIEDERHUBERENSMINGERGYVES JWJ. Regional chemotherapy of colorectal cancer metastatic to the liver. Cancer. 1984;53:1336-43. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Lake Community Hospital Leesburg, FL 32748 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byEndoscopic transduodenal removal of an hepatic artery infusion catheter 1 September 1985Volume 103, Issue 3Page: 472-472KeywordsCathetersChemotherapyDrug administrationDrugsDuodenal ulcersFood and Drug AdministrationGastritisLiver diseasesUlcers ePublished: 1 December 2008 Issue Published: 1 September 1985 PDF downloadLoading ...
Determination of Left Atrial Appendage Morphology
Authors: Günther Ernst, Claudia Stöllberger, Josef Finsterer
Journal: Circulation (1998)

Veinot et al 1 reviewed 500 heart specimens from autopsies during a 22-year period.They described the anatomy of the left atrial appendage (LAA) by determining orifice diameter, width, length, and number of lobes.They found orifice size, width, and length to be age and sex related.In men and women aged Ͼ20 years, mean orifice diameters of 1.16 and 1.07 cm, length of 2.59 and 2.53 cm, and width of 1.83 and 1.66 cm were found, respectively, as well as 1 to 4 lobes.In a study on 220 LAA casts obtained shortly after death, 2 we determined LAA morphology by describing the course and ramifications of the principal axis and by measuring minimal and maximal orifice diameters, length (bottom to top), width (at right angles), and volume.The course of the principal axis was straight (7%), slightly bent and slightly spiral (23%), slightly bent and extremely spiral (5%), extremely bent and slightly spiral (24%), or extremely bent and extremely spiral (42%).Fifty-six percent of the casts had Ͼ5 branches (orifice area Ͼ10 mm 2 ), and 47% had Ͼ40 twigs (orifice area 1 to 10 mm 2 ).The mean minimal and maximal orifice diameters were 15 and 21 mm, respectively.Mean length was 30 mm, width was 31 mm, and volume was 5220 mm 3 .The casts of 35 cases with normal cardiac findings were not different from those that showed pathological cardiac findings at autopsy.Differences between the results of the study by Veinot et al and our results can be explained as follows:1.The specimens used in the 2 studies were of different age and type of conservation.It is possible that the years of conservation led to a shrinkage and change of the elastic properties of the LAA tissue, whereas casting possibly led to dilation of the LAA.This assumption is supported by the shorter LAA length in the study by Veinot et al compared with our study.Furthermore, the number of LAA outpouchings is lower in their study compared with our study.2. Veinot et al measured the LAA tissue, whereas we measured synthetic resin casts.3. The orifice diameters were measured differently.4. Veinot et al measured width as the widest external width, whereas we measured at right angles, perpendicular to the bottom-to-top axis. 5.The definition of lobes in the study by Veinot et al differed from our definition of branches and twigs.We conclude that postmortem casts may reflect the intravitam morphology of the LAA more closely than specimens conserved for years.We demonstrate that the anatomy and morphology of the LAA is more complex, bizarre, and variable than previously thought.This should be considered when images of the LAA are being interpreted, in particular when thrombi are being diagnosed.
Efficacy and safety of colonoscopy in the UK NHS bowel cancer screening programme
Authors: T. J. W. Lee, R. G. Blanks, M. D. Rutter, S. M. Moss, A. F. Goddard, A. Chilton, C. Nickerson, R. J. Q. McNally, J. Patnick, C. J. Rees
Journal: Gut (2011)

<h3>Introduction</h3> Colonoscopy is a central investigation in all colorectal cancer (CRC) screening strategies. Success of CRC screening is dependent on the quality of colonoscopy. The NHS Bowel Cancer Screening Programme (BCSP) offers biennial faecal occult blood testing to adults aged 60–74 years. Colonoscopy is offered to individuals with a positive faecal occult blood (FOB) test. All colonoscopists practicing within the screening programme are required to meet predefined standards through summative assessment and are subject to ongoing quality assurance. In this study we examine the quality of colonoscopy in the NHS BCSP and describe the measures taken by the BCSP to achieve high quality colonoscopy. Comparison of current quality indicators with existing quality standards and evidence from the UK pilot study of FOB screening will be undertaken. <h3>Methods</h3> The NHS BCSP national database prospectively collects detailed data on all screening colonoscopies. Data from the first 3 years of the programme (August 2006 to August 2009) were analysed. Colonoscopy quality indicators (adenoma detection rate, polyp detection rate, colonoscopy withdrawal time, caecal intubation rate, rectal retroversion rate, polyp retrieval rate, mean sedation doses, patient comfort scores, bowel preparation quality and adverse event incidence) were calculated for this period. All screening centres were contacted directly to verify adverse event data. <h3>Results</h3> In the study period, 2,269,983 individuals returned FOB tests and 36,460 colonoscopies were performed. Mean caecal intubation rate was 95.2% and mean withdrawal time for normal procedures was 9.2 min. The mean adenoma detection rate (ADR) per colonoscopist was 46.5%. ADR did not differ between prevalent and incident rounds (p = 0.90). Patient comfort scores were high and adverse event rates low. <h3>Conclusion</h3> The NHS Bowel Cancer Screening Programme provides high quality colonoscopy as demonstrated by high caecal intubation rate, adenoma detection rate and comfort scores and low adverse event rate. This quality is achieved by ensuring that BCSP colonoscopists are trained to a high standard and that these standards are maintained through ongoing quality assurance measures.
Abstract 4282: High content multiparametric functional screen for regulators of epithelial-mesenchymal transition identifies genes associated with chemoresistance
Authors: Elizabeth D. Williams, Nur Akmarina Said, Cathryn M. Gould, Erik W. Thompson, Kaylene J. Simpson
Journal: Cancer Research (2014)

Abstract Metastasis accounts for the majority of treatment-refractory cancers and poor prognosis of the disease. The phenotypic transition of non-motile epithelial tumor cells to migratory and invasive ‘mesenchymal’ cells enables the escape of cancer cells from the primary tumor into the circulation. Morphological changes from cobblestone epithelial cells to elongated and spindle-shaped cells is a key feature of this process. This transition is also marked by upregulation of vimentin, an intermediate filament found in mesenchymal cells. We have previously developed a bladder cancer model with a step-wise enhancement in the metastatic cascade that we have used to interrogate the role of tumor cell plasticity in metastasis (1). Given the need to elucidate pathways and assign functions to particular genes involved in this process, we conducted a high content screening assay across genome wide siRNA, miRNA and kinase inhibitor (131 compounds) libraries to systematically identify modulators of EMT/MET. We identified candidate gene regulators of EMT in TSU-Pr1-B1 bladder cancer cells using the readouts of morphological change (cells stained with CMFDA) and a vimentin promoter activity (dsRed reporter construct). Following integration of the predicted target genes for miRNA hits and kinase inhibitors with siRNA hits, initial validation using a siRNA deconvolution strategy was performed for 400 targets. 221 siRNAs were classified as inducing statistically significant effects on cell shape and/or vimentin promoter reporter activity (defined as at least 2/4 duplexes inducing the effect for a given target). Gene ontology and pathway analyses feature cell cycle and various developmental pathways. Furthermore, the validated gene list was associated with bladder cancer histology and drug sensitivity in clinical specimens in multiple cancer types (Oncomine). Molecules identified in this assay will be further analysed using functional assays to determine their role in maintaining the epithelial phenotype and as regulators of chemoresistance. (1) Chaffer et al. (2005) Clin Exp Metastasis 22: 115-25. Citation Format: Elizabeth D. Williams, Nur Akmarina Said, Cathryn M. Gould, Erik W. Thompson, Kaylene J. Simpson. High content multiparametric functional screen for regulators of epithelial-mesenchymal transition identifies genes associated with chemoresistance. [abstract]. In: Proceedings of the 105th Annual Meeting of the American Association for Cancer Research; 2014 Apr 5-9; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2014;74(19 Suppl):Abstract nr 4282. doi:10.1158/1538-7445.AM2014-4282
Antiviral Agents for Influenza—Reply
Authors: Richard P. Wenzel
Journal: JAMA (2000)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Abstract 14813: Pre-Treatment With Thienopyridines Reduces The Amount of Myonecrosis in Acute Coronary Syndrome Patients Invasively Managed: Insights from the CHAMPION trials
Authors: Sergio Leonardi, Amanda Stebbins, Renato D Lopes, Yuliya Lokhnygina, Deepak L Bhatt, Gregg W Stone, Michael A Lincoff, Harold L Dauerman, C. Michael Gibson, Harvey D White, Keyur Parick, Luis Gruberg, Howard C Herrmann, Brent T McLaurin, Shaun Goodman, Robert A Harrington, Kenneth W Mahaffey
Journal: Circulation (2010)

Introduction: Clopidogrel pretreatment is beneficial in acute coronary syndrome (ACS) patients managed invasively but its effect on the extent of myonecrosis after PCI has not been explored. We inv...
Abstract 20125: MitraClip Acute Outcomes are Similar in Functional vs. Degenerative Mitral Regurgitation: A Meta-analysis of Observational Studies
Authors: Sainath Gaddam, Vratika Agarwal, Armaghan Soomro, Bhavi Pandya, Srinivas Duvvuri, Donald McCord, James Lafferty, Ruben Kandov, Roman Royzman, Melanie Cottone, Chad Kliger
Journal: Circulation (2014)

Introduction: Percutaneous mitral valve repair using MitraClip (MC) is recommended by 2014 AHA/ACC valvular heart disease guidelines, only for inoperable symptomatic chronic degenerative MR (DMR) patients on optimal medical therapy (Class IIb). However outside USA, MC is extensively utilized for severe functional MR (FMR), with some recent registries suggesting increased success with FMR when compared to DMR. Randomized control trials to evaluate MC success in functional MR are ongoing. Aim: To evaluate the short term efficacy and safety of MC in FMR vs. DMR Methods and Results: PubMed, EMBASE, Google scholar database and international meeting abstracts were searched for all observational MC studies. Studies which did not specify type of MR or where post-procedural results were not delineated between the types of MR were excluded from the analysis. We defined acute procedural success (APS) in our analysis as decrease in MR severity to ≤ 2 at the time of discharge or within 30 days post procedure and MACE ...
CLOSED INTRAPLEURAL PNEUMOLYSIS
Authors: James H. Forsee
Journal: Annals of Internal Medicine (1935)

Article1 April 1935CLOSED INTRAPLEURAL PNEUMOLYSISJAMES H. FORSEE, M.D.JAMES H. FORSEE, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-8-10-1309 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe marked progress which is steadily being made in the surgical treatment of pulmonary tuberculosis demands that we frequently report the progress achieved by any particular procedure of compression therapy. Such a report must include not only a description of any improvement in operative technic but also recommendations regarding the selection of cases with an accurate survey of the results obtained by the particular method. The particular procedure to be discussed in this paper is closed intrapleural pneumolysis utilizing the electro-surgical method. The report is based upon my experience in 30 thoracoscopies with the cauterization of adhesions in most instances....References1. MOORE JA: Intrapleural pneumolysis, Jr. Thorac. Surg., 1934, iii, 276-300. CrossrefGoogle Scholar2. MATSON RC: The electrosurgical method of closed intrapleural pneumolysis in artificial pneumothorax, Arch. Surg., 1929, xix, 1175-1192. CrossrefGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Denver, Colorado*Published by permission of the Surgeon General, U. S. Army.Read before the Rocky Mountain Tuberculosis Conference, Colorado Springs, Colorado September 18 to 19, 1934.From the Medical Service, Fitzsimons General Hospital, Denver, Colo. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byCLOSED INTRAPLEURAL PNEUMONOLYSISBRONCHOPLEURAL FISTULAS COMPLICATING PULMONARY TUBERCULOSISUNUSUAL COMPLICATIONS FOLLOWING CLOSED INTRAPLEURAL PNEUMOLYSIS* 1 April 1935Volume 8, Issue 10Page: 1309-1314KeywordsMedical servicesSurgeons ePublished: 1 December 2008 Issue Published: 1 April 1935 PDF downloadLoading ...
Abstract 2087: Does an Internet-Based Intervention Reduce Use of Emergency Services Among Patients with Chronic Cardiac Disease?
Authors: Laura J Burke, Gail Casper, Margaret D Sebern, Calvin Or, Rupa Valdez, Patricia F Brennan
Journal: Circulation (2008)

Background:  Immediate post-hospital support, using Visiting Nurse Association (VNA) services, improves self-management for patients with chronic cardiac disease. Patients who need nurse-directed coaching and symptom management in the home may benefit from complementary internet-based services.   Objective:  We compared usual post-hospital VNA services with technology-enhanced VNA practice (TEP) that combined nursing care with a 6 month web-based coaching and symptom management service and examined its effect on emergency service use.   Methods : Patients (N=281) admitted to VNA service post-hospital for management of chronic cardiac diseases were randomly assigned to one of two groups: usual care or TEP. In both groups, VNA service ranged from two days to two months; the nurses coached patients to use self-management skills of knowledge-seeking, self-monitoring, and symptom management. Patients in the usual care group (N=135, 48%) used paper-based teaching materials such as booklets and diaries to improve self-management. Patients in the TEP group (N=146, 52%) received VNA and HeartCareII services, which included using a computer to find information, monitor symptoms, and solve symptom problems. The outcome of emergency service use was measured by patient recall and verified by medical record review when possible.   Results:  The typical patient was 64 years old; male (61%), post-heart surgery (64%), NYHA Class III (61%). Thirty-five percent had heart failure as the primary diagnosis. There were no baseline differences between groups on demographic and clinical variables. Patients in the TEP group used the Web resource an average of 13 times during the 6 months that it was available. Overall, emergency service use was low in this population over six months of follow-up (N=260 uses/1463 measurement points=17.8%). A total of 120 (42%) patients sought emergency care, and patients in the TEP group (N=54, 45%) were just as likely as patients in the usual care group (N=66, 55%) to use emergency services throughout the 6 months after study enrollment.(X2=.76, df=1, p=NS).   Conclusions:  Emergency service use was low overall. Access to coaching and self-monitoring tools provided through a patient-directed internet resource did not affect emergency service use.
India launches oral health strategy
Authors: Rohit Sharma
Journal: BMJ (2000)

The Indian government is about to launch a programme to tackle the subcontinent's poor standards of oral and dental health. The campaign will raise awareness of the dangers of sugary food and tobacco products.

“Periodontal disease affects 90-95% of our population, and dental caries affects 60-80% of our children,” said Hari Parkash, president of the Indian Dental Association and head of dental surgery at the All India Institute of Medical Sciences, New Delhi. Malocclusion of teeth is also common among …