Pancreatitis Possibly Related to 2-3-Dideoxycytidine
Authors: Sandra Leonora Aponte-Cipriani
Journal: Annals of Internal Medicine (1993)

Letters15 September 1993Pancreatitis Possibly Related to 2-3-DideoxycytidineSandra Leonora Aponte-Cipriani, MD, Carl Teplitz, MD, and Stanley Yancovitz, MDSandra Leonora Aponte-Cipriani, MDSearch for more papers by this author, Carl Teplitz, MDSearch for more papers by this author, and Stanley Yancovitz, MDSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-119-6-199309150-00034 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:To improve the treatment of the acquired immunodeficiency syndrome, clinical trials are under way in which the nucleoside analogs 2,3-dideoxycytidine (ddC) and 3-azido-23-dideoxythymidine (zidovudine, AZT) are being tested simultaneously, intermittently, or in an alternating regimen [1, 2]. Combination of these two antiretroviral agents might allow the use of lower or less frequent doses, thus minimizing the individual or selective drug toxicities or both [1]. None of the preliminary reports published have identified acute pancreatitis as a toxic effect of ddC [3]. Preliminary reports of clinical trials using another nucleoside analog, 2,3-dideoxyinosine (ddI), mention sporadic cases of acute ...References1. Broder S, Yarchoan R. Dideoxycytidine: current clinical experience and future prospects. Am J Med. 1991; 88:31-3. Google Scholar2. Broder S. Dideoxycytidine (ddc): A potent antiretroviral agent for human immunodeficiency virus infection. Am J Med. 1990; 88:1-7. Google Scholar3. Hoth DF Jr, Myers MW, Stein DS. Current status of HIV therapy: I. Antiretroviral agents. Hosp Pract. 1992; 27:145-56. Google Scholar4. Schwartz MS, Brandt LJ. The spectrum of pancreatic disorders in patients with acquired immunodeficiency syndrome. Am J Gastroenterol. 1989; 84:459-62. Google Scholar5. Steer JS, Underhill LH. The cell biology of pancreatitis. N Engl J Med. 1987; 316:144-50. Google Scholar Author, Article, and Disclosure InformationAffiliations: PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByAntiretroviral drugs and acute pancreatitis in HIV/AIDS patients: is there any association? A literature reviewSublethal concentrations of gemcitabine (2′,2′-difluorodeoxycytidine) alter mitochondrial ultrastructure and function without reducing mitochondrial DNA content in BxPC-3 human pancreatic carcinoma cellsStavudine, Didanosine, and ZalcitabinePancreatitis in Hiv Infection: Predictors of SeverityAcute pancreatitis in human immunodeficiency virus–infected patients: a reviewAcute PancreatitisDiabète sucré médicamenteux au cours de l'infection par le VIH. A propos de cinq casTHE PANCREAS IN AIDSPrinciples of clinical pharmacology in postexposure prophylaxisAntiviral drugsZalcitabine 15 September 1993Volume 119, Issue 6Page: 539-540KeywordsAcute pancreatitisClinical trial reportingClinical trialsDrugsNecrosisNucleosidesPancreatitisPneumoniaProphylaxisVomiting Issue Published: 15 September 1993 CopyrightCopyright © 1993 by American College of Physicians. All Rights Reserved.PDF DownloadLoading ...