BRAIN ABSCESS AND MENINGITIS ASSOCIATED WITH A PLEUROPNEUMONIA-LIKE ORGANISM: CLINICAL AND BACTERIOLOGICAL OBSERVATIONS IN A CASE WITH RECOVERY
Authors: Tom Fite Paine, Roderick Murray, Irwin Perlmutter, Maxwell Finland
Journal: Annals of Internal Medicine (1950)

Case Reports1 March 1950BRAIN ABSCESS AND MENINGITIS ASSOCIATED WITH A PLEUROPNEUMONIA-LIKE ORGANISM: CLINICAL AND BACTERIOLOGICAL OBSERVATIONS IN A CASE WITH RECOVERYTOM FITE PAINE JR., M.D., RODERICK MURRAY, M.D., IRWIN PERLMUTTER, M.D., MAXWELL FINLAND, M.D., F.A.C.P.TOM FITE PAINE JR., M.D., RODERICK MURRAY, M.D., IRWIN PERLMUTTER, M.D., MAXWELL FINLAND, M.D., F.A.C.P.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-32-3-554 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe rôle of the pleuropneumonia group of microörganisms as human pathogens is still far from clear. In the case reported here a pleuropneumonia-like organism was repeatedly cultured from the central nervous system of a patient with a brain abscess and meningitis. This case is of interest because it probably represents the first one in which a pleuropneumonia-like organism was recognized in association with an infection of the central nervous system. The characteristics of the organism were studied in some detail.LITERATUREThe literature concerning the pleuropneumonia group of organisms was reviewed in 1941 by Sabin.1This group of microörganisms has...Bibliography1. Sabin AB: The filterable microorganisms of the pleuropneumonia group, Bact. Rev. 5: 1-66, 1941. CrossrefMedlineGoogle Scholar2. FindlayMackenzieMacCallumKlieneberger GMRDFOE: The aetiology of polyarthritis in the rat, Lancet 2: 7-10, 1939. CrossrefGoogle Scholar3. Edward DG: Catarrh of the upper respiratory tract in mice and its association with pleuropneumonia-like organisms, J. Path. and Bact. 59: 209-221, 1947. CrossrefMedlineGoogle Scholar4. Klieneberger E: The natural occurrence of pleuropneumonia-like organisms in apparent symbiosis with Streptobacillus moniliformis and other bacteria, J. Path. and Bact. 40: 93-105, 1935. CrossrefGoogle Scholar5. DienesEdsall LG: Observations on the L-organism of Klieneberger, Proc. Soc. Exper. Biol. and Med. 36: 740-744, 1937. CrossrefGoogle Scholar6. Sabin AB: Isolation of a filtrable, transmissible agent with "neurolytic" properties from toxoplasma-infected tissues, Science 88: 189-191, 1938. CrossrefMedlineGoogle Scholar7. FindlayKlienebergerMacCallumMackenzie GMEFORD: Rolling disease. New syndrome in mice associated with a pleuropneumonia-like organism, Lancet 2: 1511-1513, 1938. CrossrefGoogle Scholar8. Van HerickEaton WMD: An unidentified pleuropneumonia-like organism isolated during passages in chick embryos, J. Bact. 50: 47-55, 1945. CrossrefMedlineGoogle Scholar9. EdwardHancockHignett DGJLSL: Isolation of pleuropneumonia-like organisms from the bovine genital tract, Vet. Rec. 59: 329, 1947. MedlineGoogle Scholar10. LaidlawElford PPWJ: A new group of filterable organisms, Proc. Roy. Soc., B, 120: 292-303, 1936. Google Scholar11. Dienes L: Pleuropneumonia and pleuropneumonia-like organisms (Borrelomycetaceae), Suppl. No. 3 in "Bergey's Manual of Determinative Bacteriology," 6th Ed., 1948, Williams and Wilkins Co., Baltimore, pp. 1289-1296. Google Scholar12. Warren J: Observations on some biological characteristics of organisms of the pleuropneumonia group, J. Bact. 43: 211-228, 1942. CrossrefMedlineGoogle Scholar13. DienesRopesSmithMadoffBauer LMWWESW: The role of pleuropneumonia-like organisms in genitourinary and joint diseases, New England J. Med., 238: 509-515 and 563-567, 1948. CrossrefMedlineGoogle Scholar14. HerschbergerDantesShwartzman CDAG: A case of subacute bacterial endocarditis caused by an unusual microorganism related to the "pleuropneumonia-like" or Grahamella group, J. Mt. Sinai Hosp. 12: 295-308, 1945. Google Scholar15. WallersteinValleeTurner RBL: The possible relationship of the pleuropneumonia-like organisms to Reiter's disease, rheumatoid arthritis and ulcerative colitis, J. Infect. Dis. 79: 134-140, 1946. CrossrefMedlineGoogle Scholar16. Sabin AB: The pleuropneumonia group, Chapter in Dubos, R. (Editor) "Textbook of Medical Bacteriology," in press. Google Scholar17. SabinWarren ABJ: The curative effect of certain gold compounds on experimental, proliferative chronic arthritis in mice, J. Bact., 40: 823-856, 1940. CrossrefMedlineGoogle Scholar18. BrownHayes TMGS: Isolation of microorganisms of the pleuropneumonia group from apparently pure cultures of the gonococcus (Neisseria gonorrheae), J. Bact. (Abstract) 43: 82, 1942. Google Scholar19. Salaman MH: The isolation of organisms of the pleuropneumonia group from the genital tract of men and women, J. Path. and Bact. 58: 31-35, 1946. CrossrefMedlineGoogle Scholar20. PowellJamiesonRice HMWARM: Effectiveness of streptomycin in arthritis of rats, Proc. Soc. Exper. Biol. and Med. 62: 8-9, 1946. CrossrefMedlineGoogle Scholar21. BeveridgeCampbellLind WIADPE: Pleuropneumonia-like organisms in cases of non-gonococcal urethritis in man and in normal female genitalia, M. J. Australia 1: 179, 1946. CrossrefMedlineGoogle Scholar22. Edward DG: A selective medium for pleuropneumonia-like organisms, J. Gen. Microbiol. 1: 238-243, 1947. MedlineGoogle Scholar23. WarrenSabin JAB: Some biologic and immunologic characteristics of a pleuropneumonia-like microorganism of human origin, Proc. Soc. Exper. Biol. and Med. 51: 24-26, 1942. CrossrefGoogle Scholar24. JohnsonAnkerMeleney BAHFL: Bacitracin: a new antibiotic produced by a member of the B. subtilis group, Science 102: 376-377, 1945. CrossrefMedlineGoogle Scholar25. StansleyShepherdWhite PGRGHJ: Polymyxin: a new chemotherapeutic agent, Bull. Johns Hopkins Hosp. 81: 43-54, 1947. MedlineGoogle Scholar26. PaineFinland TFM: Observations on streptomycin-sensitive, resistant and dependent bacteria, J. Bact. 56: 489, 1948. CrossrefMedlineGoogle Scholar27. SabinJohnson ABB: Search for microorganisms of the pleuropneumonia group in rheumatic and non-rheumatic children, Proc. Soc. Exper. Biol. and Med. 44: 565-569, 1940. CrossrefGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: *Received for publication July 8, 1948.From the Thorndike Memorial Laboratory, Second and Fourth Medical (Harvard) and Neurosurgical Services, Boston City Hospital and the Department of Medicine, Harvard Medical School, Boston, Mass.Aided by a grant from the United States Public Health Service.†Research Fellow, American College of Physicians. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byMeningitis in a Chinese adult patient caused by Mycoplasma hominis: a rare infection and literature reviewFatal nosocomial meningitis caused by Mycoplasma hominis in an adult patient: case report and review of the literatureDiagnosis and antimicrobial therapy of Mycoplasma hominis meningitis in adultsMycoplasma hominis infection of a subdural haematoma in the peripartum periodMycoplasma hominis abscess secondary to respiratory tract infectionInfection of a brain abscess of Mycoplasma hominisMENINGITIS IN A NEWBORN INFANT CAUSED BY MYCOPLASMA HOMINISDiagnostic biologique des infections humaines à mycoplasmesBacterial variants in central nervous system infections in infants and childrenDie Kontrastdarstellung von HirnabscessenAntibiotic Sensitivities of Oral MycoplasmaOrigins of MycoplasmasMycoplasma Infections of ManMycoplasma Species of ManTHE MYCOPLASMA (PPLO) SPECIES OF MAN*,†COMPARATIVE PHYSIOLOGY OF PLEUROPNEUMONIA-LIKE AND L-TYPE ORGANISMSThe isolation and cultivation of a filterable form resembling pleuropneumonia-like organisms from the human dental pulpPleuropneumonie�hnliche Organismen in der Hautbesiedelung bei verschiedenen DermatosenRelationship of Pleuropneumonialike Organisms and Uveitis*THE PROPAGATION OF A VIRULENT GOAT PLEUROPNEUMONIA-LIKE ORGANISM IN THE CHICK EMBRYOMICRO-ORGANISMS OF THE PLEUROPNEUMONIA GROUPDie Pleuropneumonie-Gruppe der Mikroorganismen und ihre Bedeutung f�r die MedizinPrevalence of Pleuropneumonia-like Organisms and the Evaluation of Media and Methods for Their Isolation from Clinical MaterialThe Pleuropneumonia Group of Organisms and their Significance in Genital Infection 1 March 1950Volume 32, Issue 3Page: 554-562KeywordsAbscessesBrainCentral nervous systemHospital medicineMedical servicesMeningitisPathogensResearch laboratories ePublished: 1 December 2008 Issue Published: 1 March 1950 PDF downloadLoading ...