tbuckley/cabot-search huggingface dataset:
Abnormalities of basophil “releasability” in atopic and asthmatic individuals
Authors: Marshall Plaut, Waclaw Kazimierczak, Lawrence M. Lichtenstein
Journal: Journal of Allergy and Clinical Immunology (1986)

47. Pandey JP, Ambroscht F, Fudenberg HH, Staniki G, Wiedermann G. Immunoglobulin allotypes and immune response to meningococcal polysaccharides A and C. J Immunogenet 1982;9:25-9. 48. Salier JP, Goust JM, Pandey JP, Fudenberg HH. Preferential synthesis of the Glm(l) allotype of IgGl in the central nervous system of multiple sclerosis patients. Science 1981;213: 1400. 49. Wilcox H, Marsh D. Genetic regulation of antibody heterogeneity. Immunogenetics 1978;6:209. 50. Blumenthal MN, Yunis E, Gleich G, et al. Lack of association of the immune response to ragweed antigen E, Ra3 and Ra5 with the HLA system. J Immunogenet 1981;8:379-86. 51. Marsh D, Hsu SH, Roebber M, et al. HLA-Dw2-A genetic marker for human immune response to short ragweed allergen RAS: I. Response resulting primarily from natural antigenic exposure. J Exp Med 1982;155:1439-51. 52. Coulter KM, Dorval G, Yang WH, Drouin MA, Del Carpio J, Goodfriend L. Presented at the American Academy of Allergy, Chicago, February 1985. 53. Marsh D, Meyers D, Freidhoff L, et al. HLA-Dw2-A genetic marker for human immune response to short ragweed allergen RAS. II. Response after ragweed immunotherapy. J Exp Med 1982;155:1452-63. 54. Levine B, Stember R, Fotino M. Ragweed hay fever: genetic control and linkagae to HL-A haplotypes. Science 1972; 178:1201. 55. Blumenthal M, Amos D, Noreen H, Mendell N, Yunis E. Genetic mapping of Ir locus in man: linkage to second locus of HL-A. Science 1974;184:1301. 56. Mendell NR, Blumenthal MN, Amos DB, Yunis EJ, Elston RC. Ragweed sensitivity: segregation analysis and linkage to HLA-B. Cytogenetics 1978;22:330-4. 57. Blumenthal MN, Yunis EJ, Mendell NR, Amos B. HLA and ragweed allergy. Monogr Allergy 1977; 11:83-8. 58. Awdeh ZL, Raum D, Yunis EJ, Alper CA. Extended HLA/complement allele haplotypes: evidence for T/t-like complex in man. Proc Nat1 Acad Sci USA 1983;80:259-63. 59. Alper CA, Awdeh ZL, Raum DD, Yunis EJ. Extended major histocompatibility complex haplotypes in man: role of alleles analogous to murine t mutants. Clin Immunol Immunopathol 1982;24:276-85.
ELEVATION OF PLASMA COPEPTIN IN ACUTE MYOCARDIAL INFARCTION IN PIGS IS RELATED TO CHANGES IN MEAN ARTERIAL BLOOD PRESSURE BUT NOT TO MYOCARDIAL ISCHEMIA
Authors: Timo Jerichow, Joachim Struck, Jörn O. Vollert, Birgit Vogt, Dörte Mans, Malte Schröder, Frank Gebauer, Hassan Abdel-Aty, Anna C. Slagman, Jeanette Schulz-Menger, Ralf Schindler, Ahmed Sheriff, Martin Möckel
Journal: Journal of the American College of Cardiology (2011)
A Short Textbook of Haematology
Authors: Charles B. Clayman
Journal: JAMA (1979)

As appears to be the case for British medical texts, this short textbook of hematology provides well-written discussions of the basic physiology and pathology of the bloodforming organs. Well distributed and balanced throughout is a practical clinical emphasis. Following discussion of formation of the formed elements is a fine presentation of normal and abnormal hemoglobin, the porphyrins, and the blood groups. Anemias characterized and covered are hemolytic, iron deficiency, megaloblastic, metabolic, and aplastic. The function and disorders of the spleen lead into several chapters on Hodgkin's disease, lymphomas, leukemias, and nonlymphomatous causes of lymphadenopathy as well as polycythemia and myelofibrosis. Coverage of the lymphocyte serves as a springboard into the immunoglobulinemias, and the final chapters are concerned with coagulation and platelet aspects of the hemorrhagic disorders. Illustrations are numerous; some of the roentgenograms suffer from the reproduction, while cost prevented some of the splendid photographs and photomicrographs from being presented
New Zealand doctors resist emergency contraception
Authors: C. Williams
Journal: BMJ (1996)

Emergency contraception is expected to be available over the counter in New Zealand beginning in July 1996 as soon as appropriate labeling and packaging is manufactured despite opposition from the pharmaceutical industry. The Royal New Zealand College of General Practitioners stated that this could reduce the number of abortions and unwanted pregnancies, although the best place for women to obtain emergency contraception was from their general practitioners. Obtaining such contraceptives from pharmacies may preclude getting the medical advice that general practitioners routinely provide when administering or prescribing such contraception. The New Zealand Medical Association also has serious reservations about the free availability of such a powerful medication because it could be used as normal contraception. The spokesman for the ministry of health related that they had examined the issue of safety in detail stating that the tablets are well labeled and the benefits outweigh the risks. Schering New Zealand manufactures PC4, the only pill packaged specifically for emergency contraception, and it opposes emergency contraception being taken outside the context of a medical consultation. The concern is that the pills may be used repeatedly and incorrectly putting women at risk of very high dose contraception. This could create a major medicolegal risk for a small economic return. Neither Schering nor Wyeth companies plan to repackage the pills for making them available over the counter. If the companies do not supply the pills in new packages, the ministry of health will allow pharmacists to repackage packets of contraceptive pills and label them accordingly. The ministry wants to make the pills available through pharmacies for easy availability to improve the current limited access to them from general practitioners. People get abortions because of the difficulty of obtaining emergency contraception from general practitioners. The idea of having emergency contraception available in Britain was supported by general practitioners' and obstetricians' associations.
Comparison of Pasteur and Behringwerke antivenoms in envenoming by the carpet viper (Echis carinatus).
Authors: D A Warrell, M J Warrell, W Edgar, C R Prentice, J Mathison, J Mathison
Journal: BMJ (1980)

Bites and envenoming by the carpet viper Echis carinatus are common medical emergencies in parts of Nigeria, but the most effective use of the various commercially produced antivenoms in treatment has not been established. Pasteur Paris Echis monospecific and Behringwerke West and North Africa Bitis-Echis-Naja polyspecific antivenoms were compared in two groups of seven patients with incoagulable blood after E carinatus bites. In both groups spontaneous bleeding stopped within a few hours and local swelling subsided within two weeks after the initial antivenom injection. Pasteur antivenom (20-40 ml) restored blood coagulability within 12 hours in all cases, but 60--180 ml of Behringwerke antivenom was effective in only four cases. Persisting venom procoagulant activity was observed in the remaining three cases. Despite its potency in the mouse protection test, Behringwerke antivenom is unreliable and unpredictable in neutralising venom procoagulant in humans bitten by E carinatus.
Transmigration of ingested asbestos.
Authors: M E Meek
Journal: Environmental Health Perspectives (1983)

There has been speculation that the ingestion of asbestos in food and drinking water may play some role in the etiology of cancer of the gastrointestinal (GI) tract. An important question in the evaluation of the possible human cancer risk associated with asbestos ingestion is whether fibers can penetrate into and through the GI tract in sufficient numbers to cause adverse systemic or local effects. Factors that complicate interpretation of the available data on the transmigration of ingested asbestos are discussed, and the preliminary results of our ongoing investigation of the penetration of amosite fibers into the normal and abnormal intestinal mucosa of the Wistar rat are reported.
From the Centers for Fatigue Control (CFC) Weekly Report
Authors: Ludwig A. Lettau
Journal: Annals of Internal Medicine (1991)

Ad Libitum1 April 1991From the Centers for Fatigue Control (CFC) Weekly ReportEpidemiologic Notes and ReportsLudwig A. Lettau, MDLudwig A. Lettau, MDSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-114-7-602 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptLime Disease—United StatesFrom 1985 to 1990, the CFC has monitored the growing national epidemic of Lime disease, which appears to parallel increased public awareness and knowledge of Lyme disease. Cases have now been reported from all 50 states, but the national surveillance program has been hampered by persistent confusion between the two diseases, with clinicians frequently reporting a case of Lime disease as Lyme disease.Analysis of surveillance reports of cases fulfilling the case-definition of Lime disease indicates that Lime disease is distributed uniformly throughout the United States (in contrast to the focal geographic occurrence of Lyme disease); the... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByLyme Disease Outside InMapping the Lyme Disease ControversyPreventing LymeLiving LymeDiagnosing and Treating LymeLyme Disease, Evidence-Based Medicine, and the Biopolitics of TruthmakingThrough Lyme’s Looking GlassNotesReferencesTHE UNDERDIAGNOSIS OF NEUROPSYCHIATRIC LYME DISEASE IN CHILDREN AND ADULTSLyme diseaseLyme diseaseDiagnosing Lyme DiseaseJames R. Johnson, MDLime DiseaseRichard D. Huhn, MDLime versus Lyme DiseaseLorraine Tosiello, MD 1 April 1991Volume 114, Issue 7Page: 602-602KeywordsDisease surveillanceFatigueLyme disease Issue Published: 1 April 1991 PDF DownloadLoading ...
Graduate Medical Education
Authors: Walter C. Bornemeier
Journal: JAMA (1983)

To the Editor.—  I would like to respond to an article inThe Journalby Milan Korcok entitled  Education: Prosperitas Interrupta  (1983;249:12). Dr Korcok seems to lament that teaching hospitals, faced with continuing cost constraints, might have to reduce the size of the residency programs.  In my inaugural address as President of the American Medical Association in June 1970, I recommended that the four-year in-hospital residency might be improved by substituting at the end of a shortened in-hospital service a preceptorship with an approved practicing physician. My recommendation elicited considerable response—mostly unfavorable. Those who agreed with me did so by private communication.  Within weeks, I was invited to the National Institutes of Health to an international symposium on graduate medical education. The attendees from the European countries did not initially withhold their criticism of my recommendations, but by the end of the seminar, as I stood my ground and
STREPTOCOCCIC MENINGITIS IN THE MOTHER AND CHILD IN UTERO: REPORT OF A CASE
Authors: G. B. Kramer
Journal: JAMA (1918)

That the pregnant mother transmits infectious diseases to the child in utero is known. The transmission of measles, scarlet fever, variola, typhoid fever, malaria, recurrent fever, erysipelas, cholera, bubonic plague, anthrax, tuberculosis, syphilis and pus infection from the mother to the child in utero have been reported, but this case is an exceedingly interesting one, especially for those who are interested in the elective localization of streptococci. <h3>REPORT OF CASE</h3><h3>History.</h3> —A. C., a white woman, aged 24, admitted to the City and County Hospital, St. Paul, April 12, 1918, had been complaining of backache since Jan. 1, 1918, and since that time had been treated by her local physician. The nature of the treatments were unknown to the patient's sister, from whom the history was obtained. About ten days before admission to the hospital, the patient complained of a cold, backache, sore throat and pains in the chest. She
[603] R1479, A NOVEL NUCLEOSIDE ANALOG AND POTENT INHIBITOR OF HCV REPLICATION, DOES NOT AFFECT RIBAVIRIN-INDUCED HEMOLYSIS AND ERYTHROCYTE FRAGILITY IN VITRO
Authors: W.R. Jiang, J. Symons, N. Cammack, K. Klumpp
Journal: Journal of Hepatology (2007)
Tax tussle to get big tobacco firms to pay for quit programmes
Authors: B. Burton
Journal: BMJ (2002)

If a 39 year old Sydney woman, Myriam Cauvin, gets her way, two of the world's biggest tobacco corporations will hand over £95m ($US131m; €150m) for the establishment of a fund to help smokers quit their habit.

On 12 June Ms Cauvin's legal counsel, Maurice May, argued before New South Wales Supreme Court that British American Tobacco and Philip Morris should be directed to deposit the money into a special court …
Vitamin D status and secondary hyperparathyroidism: The importance of 25-hydroxyvitamin D cut-off levels
Authors: Carlos Gómez-Alonso, Manuel L. Naves-Díaz, Jose L. Fernández-Martín, Jose B. Díaz-López, Maria T. Fernández-Coto, Jorge B. Cannata-Andía
Journal: Kidney International (2003)
Blood Measurements: Microwaving Blood as a Non‐Destructive Technique for Haemoglobin Measurements on Microlitre Samples (Adv. Healthcare Mater. 4/2014)
Authors: Toby H. Basey‐Fisher, Nadia Guerra, Chiara Triulzi, Andrew Gregory, Stephen M. Hanham, Molly M. Stevens, Stefan A. Maier, Norbert Klein
Journal: Advanced Healthcare Materials (2014)

The electric field component of the microwaves emanating from the dielectric resonator is able to penetrate the microfluidic channel, serum, and individual blood cells. Subsequently, it interacts with every hemoglobin molecule present within each red blood cell. On page 536 , Toby H. Basey-Fisher and team conclude that the dielectric contrast between water and hemoglobin means that a change in the hemoglobin concentration leads to a change in the microwave response.
Pemetrexed (P) plus gemcitabine (G) as front-line chemotherapy for patients with locally advanced or metastatic non-small cell lung cancer (NSCLC): A phase II clinical trial
Authors: M. McCleod, J. Treat, N. P. Christiansen, D. M. Mintzer, P. Bonomi, L. P. Bloss, L. Taylor, M. J. Monberg, Z. Ye, C. K. Obasaju
Journal: Journal of Clinical Oncology (2005)

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Paradoxical use of angiography with advancing age: insights from an international trial population
Authors: Karen P. Alexander, Manju V. Bhapkar, Harvey D. White, Judith S. Hochman, Mathias E. Pfisterer, David J. Moliterno, Robert M. Califf, Eric D. Peterson, Frans Van der Werf, Paul W. Armstrong, Kristin Newby
Journal: Journal of the American College of Cardiology (2002)
EVEROLIMUS (RAD001) AND THE MTOR PATHWAY IN LOW-GRADE GLIOMAS
Authors: J. L. Clarke, S. Chang, J. Phillips, A. Molinaro, M. Berger, S. Nelson, D. Haas-Kogan
Journal: Neuro-Oncology (2014)

BACKGROUND: Low-grade gliomas (LGG) are slow growing, primary brain tumors that frequently recur after primary surgical treatment. Recent work has suggested the activation of the PI3K/mTOR pathway in >50% of LGG, raising the possibility that treatment with mTOR inhibitors such as everolimus (RAD001) may benefit patients with LGG. METHODS: We have an ongoing single-institution phase II clinical trial testing everolimus 10 mg daily in patients with recurrent low-grade gliomas. Primary outcome is 6-month progression-free survival (PFS-6). Secondary outcomes include safety, overall survival, overall response rate, and assessment of the correlation between molecular markers and outcome. A molecularly selected phase II clinical trial for newly diagnosed grade II gliomas is now under development; patients' tumors will be evaluated for 1p/19q chromosomal status as well as PRAS-40 and ribosomal S6 activation as markers of mTOR pathway activation. RESULTS: Accrual in the study for recurrent patients is ongoing, with 48 patients enrolled thus far of 60 total planned. Treatment has been well tolerated. Preliminary PFS-6 for those patients accrued thus far is 72%. Preliminary correlation of results with molecular markers raises the possibility that patients treated with everolimus whose tumors have PRAS-40 activation may have improved PFS vs. treated patients with non-activated tumors (p = 0.03). In contrast, patients with PRAS-40 activated tumors in a historical control trended toward worse PFS than patients with non-activated tumors (p = 0.07). Further molecular characterization, including IDH1/IDH2 status and 1p/19q chromosomal status, is also planned. We will provide updated results at the conference, and will also discuss the design of the study under development for newly diagnosed patients. CONCLUSIONS: Inhibition of the PI3K/mTOR pathway by everolimus is a promising avenue of treatment for low-grade gliomas. SECONDARY CATEGORY: Neuropathology & Tumor Biomarkers.
(2) Transient acantholytic dermatosis
Authors: C.B. Bentley-Phillips, G.C. Wells
Journal: British Journal of Dermatology (2006)

In experiments designed to elucidate the role of divalent cations in maintaining the integrity of the epidermis, newborn mouse skin was incubated in ethylenediamine tetraacetic acid (EDTA) or ethylene glycol tetraacetic acid (EGTA). In EDTA, epidermolysis occurred and was confirmed by rubbing the specimen to demonstrate that a sheet of epidermis could be split off. After 30 min incubation in 0-01 mol/EDTA the split occurred in the lower granular-upper spinous layer; after 45 min, it was in a spinous-suprabasilar location and at 60 min and later at the dermal-epidermal junction. Ultrastructurally, a clear zone of apparent intracellular oedema occurred along the cell membranes. The split then occurred intracytoplasmally through this clear zone and the adjacent cell membrane was lost. Since incubation in EGTA at pH 7-4 did not result in epidermolysis, we suggest that the removal of magnesium rather than calcium is responsible for epidermolysis. Thirty min after the addition of either calcium or magnesium to EDTA-treated specimens, epidermolysis could no longer be demonstrated.
Mitochondrial Ca <sup>2+</sup> -Activated K <sup>+</sup> Channels in Cardiac Myocytes
Authors: Toshiaki Sato, Tomoaki Saito, Noriko Saegusa, Haruaki Nakaya
Journal: Circulation (2004)

The large-conductance Ca2+-activated K+ (BK(Ca)) channel in the cardiac inner mitochondrial membrane (mitoK(Ca) channel) has been shown to protect the heart against ischemic injury. However, questions about the cardioprotective mechanism and the kinase-mediated regulation of mitoK(Ca) channels remain to be answered.Flavoprotein fluorescence in guinea pig ventricular myocytes was measured to assay mitoK(Ca) channel activity. The mitochondrial Ca2+ concentration ([Ca2+]m) and membrane potential (DeltaPsi(m)) were measured by loading cells with rhod-2 and JC-1, respectively. Cell death was assessed by trypan blue permeability. The BK(Ca) channel opener NS1619 reversibly increased the flavoprotein oxidation in a concentration-dependent manner. NS1619 (30 micromol/L) attenuated the ouabain (1 mmol/L)-induced elevation of [Ca2+]m with accompanying depolarization of DeltaPsi(m). These effects of NS1619 were completely antagonized by the BK(Ca) channel blocker paxilline (2 micromol/L) but not by the mitochondrial ATP-sensitive K+ (mitoK(ATP)) channel blocker 5-hydroxydecanoate (500 micromol/L). Paxilline, however, failed to block the oxidative effect of diazoxide (100 micromol/L), a mitoK(ATP) channel opener. The combined application of submaximally effective concentrations of NS1619 (10 micromol/L) and diazoxide (30 micromol/L) produced additive effects. NS1619 (30 micromol/L) blunted the rate of cell death during exposure to ouabain; this cardioprotective effect was prevented by paxilline. Activation of cAMP-dependent protein kinase by 8-bromoadenosine 3'5'-cyclic monophosphate (0.5 mmol/L) and forskolin (10 micromol/L) potentiated the NS1619-induced flavoprotein oxidation.Opening of mitoK(Ca) channels, which is modulated by cAMP-dependent protein kinase, depolarizes the DeltaPsi(m) and attenuates the mitochondrial Ca2+ overload. Our study further indicates that mitoK(Ca) channel activation confers cardioprotection in a manner similar to but independent of mitoK(ATP) channel activation.
Neonatal intensive care. Staff must be experienced.
Authors: K Dodd
Journal: BMJ (1993)

on previously was taking both desmopressin and methylphenidate.2Desmopressin, imipramine, and methylphenidate are centrally acting drugs, which act as neurotransmitters.The antidiuretic action of desmopressin might possibly be augmented by imipramine and methylphenidate.We agree with Hamed and colleagues that parents should be warned of the dangers of excessive fluid intake when desmopressin is used.We suggest that current treatment with a centrally acting drug should be considered a relative contraindication to treatment with desmo- pressin.We also suggest that any patient who develops vomiting, headache, or nausea during treatment with desmopressin should stop taking the drug and see his or her doctor promptly.
Sleep-Disordered Breathing and Cognitive Decline in Older Adults
Authors: Nicola Canessa, Luigi Ferini-Strambi
Journal: JAMA (2011)

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