tbuckley/cabot-search huggingface dataset:
Bone marrow-derived immune cells mediate sensitization to liver injury in a myeloid differentiation factor 88-dependent fashion
Authors: Istvan Hritz, Arumugam Velayudham, Angela Dolganiuc, Karen Kodys, Pranoti Mandrekar, Evelyn Kurt‐Jones, Gyongyi Szabo
Journal: Hepatology (2008)

Toll-like receptors (TLRs) expressed on both immune cells and hepatocytes recognize microbial danger signals and regulate immune responses. Previous studies showed that TLR9 and TLR2 mediate Propionibacterium acnes–induced sensitization to lipopolysaccharide-triggered acute liver injury in mice. Ligand-specific activation of TLR2 and TLR9 are dependent on the common TLR adaptor, myeloid differentiation factor 88 (MyD88). Here, we dissected the role of MyD88 in parenchymal and bone marrow (BM)–derived cells in liver sensitization. Using chimeric mice with green fluorescent protein–expressing BM cells, we identified that P. acnes–induced liver inflammatory foci are of BM origin. Chimeras with MyD88-deficient BM showed no inflammatory foci after P. acnes or TLR2+TLR9 challenge, suggesting that recruitment of inflammatory cells to the liver required MyD88 expression in BM-derived cells. Further, selective MyD88 deficiency in parenchymal cells in mice with wild-type BM failed to prevent inflammatory cell infiltration. These results demonstrate that MyD88 in immune cells rather than in liver parenchymal cells plays an important role in inflammatory cell recruitment and liver injury. (HEPATOLOGY 2008.)
Gas Gangrene After Intramuscular Injection
Authors: Sidney Shaw
Journal: JAMA (1963)

<h3>To the Editor:</h3> —In (<i>JAMA</i><b>181</b>:901 [Sept 8] 1962) an article by Dr. Edward S. Brewster entitled, "Gas Gangrene Following an Intramuscular Injection of Concentrated Liver Extract" describes what is believed to be the second case of gas gangrene occurring after parenteral injection, in the United States. In a survey of the world medical literature the author refers to only two cases from Great Britain, reported in 1946 and 1956. In view of the rarity but extreme gravity of this condition, we would draw attention to our case described in 1953, "Clostridial Myositis Associated with Injections of Sodium Sulphathiazole" (<i>Brit Med J</i><b>1</b>:429, 1953).
LOCALISATION OF 11β-HYDROXYSTEROID DEHYDROGENASE—TISSUE SPECIFIC PROTECTOR OF THE MINERALOCORTICOID RECEPTOR
Authors: C.R.W. Edwards, D. Burt, M.A. Mcintyre, E.R. De Kloet, P.M. Stewart, L. Brett, W.S. Sutanto, C. Monder
Journal: The Lancet (1988)
Decline in measles mortality: nutrition, age at infection, or exposure?
Authors: P. Aaby, J. Bukh, I. M. Lisse, M. C. da Silva
Journal: BMJ (1988)

The mortality from measles was studied in an urban area of Guinea-Bissau one year before and five years after the introduction of a vaccination programme. The years after the introduction of immunisation saw a decline in mortality among unvaccinated children with measles. This decline occurred despite a lower age at infection and an increasing prevalence of malnourished children. State of nutrition (weight for age) did not affect the outcome of measles infection. The incidence of isolated cases, however, increased in the period after the introduction of measles vaccination. As mortality was lower among these cases, diminished clustering explained some of the reduction in mortality. Comparison between the urban district and a rural area inhabited by the same ethnic group showed a lower age at infection, less clustering of cases, and lower case fatality ratios in the urban area. Endemic transmission of measles in urban districts leads to less clustering of cases, which may help explain the usually lower case fatality ratios in these areas. As measles vaccination increases herd immunity and diminishes clustering of cases, it may reduce mortality even among unvaccinated children who contract the disease.
Ultraviolet responses of Gorlin syndrome primary skin cells
Authors: F. Brellier, A. Valin, O. Chevallier-Lagente, P. Gorry, M.-F. Avril, T. Magnaldo
Journal: British Journal of Dermatology (2008)

Journal Article Ultraviolet responses of Gorlin syndrome primary skin cells Get access F. Brellier, F. Brellier Friedrich Miescher Institute for Biomedical Research, Maulbeerstrasse 66, CH‐4058, Basel, Switzerland Search for other works by this author on: Oxford Academic Google Scholar A. Valin, A. Valin FRE 2939 Genomes and Cancers, Institut Gustave Roussy, 39 rue Camille Desmoulins, 94805 Villejuif cedex 05, France Search for other works by this author on: Oxford Academic Google Scholar O. Chevallier‐Lagente, O. Chevallier‐Lagente FRE 2939 Genomes and Cancers, Institut Gustave Roussy, 39 rue Camille Desmoulins, 94805 Villejuif cedex 05, France Search for other works by this author on: Oxford Academic Google Scholar P. Gorry, P. Gorry Service de Génétique, CHU Pellegrin‐Enfants, CHU de Bordeaux, place Amélie Raba‐Léon, 33076 Bordeaux, France Search for other works by this author on: Oxford Academic Google Scholar M.‐F. Avril, M.‐F. Avril AP‐HP, Hôpital Cochin, Service de Dermatologie, Université René Descartes Paris 5, 89 rue d'Assas, 75006 Paris, France Correspondence: Thierry Magnaldo and Marie‐Françoise Avril. E‐mail: magnaldo@igr.fr;magnaldo@noos.fr;marie‐francoise.avril@cch.aphp.fr Search for other works by this author on: Oxford Academic Google Scholar T. Magnaldo T. Magnaldo FRE 2939 Genomes and Cancers, Institut Gustave Roussy, 39 rue Camille Desmoulins, 94805 Villejuif cedex 05, France Correspondence: Thierry Magnaldo and Marie‐Françoise Avril. E‐mail: magnaldo@igr.fr;magnaldo@noos.fr;marie‐francoise.avril@cch.aphp.fr Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 159, Issue 2, 1 August 2008, Pages 445–452, https://doi.org/10.1111/j.1365-2133.2008.08650.x Published: 01 August 2008
Diagnosis and management of primary hyperparathyroidism
Authors: S. Pallan, M. O. Rahman, A. A. Khan
Journal: BMJ (2012)

#### Summary points

Primary hyperparathyroidism is the most common cause of hypercalcaemia in the ambulatory setting.1 2 Although this condition can occur at any age, it commonly affects people over the age of 50 years and postmenopausal women.2 3 Over the past few decades it has changed from being a condition usually defined by its symptoms to one that is often discovered on routine screening tests while the patient is still largely asymptomatic. In light of advances in research, new guidelines on the diagnosis and management of asymptomatic primary hyperparathyroidism have recently been developed. We review the presentation, diagnosis, and management of primary hyperparathyroidism for the generalist doctor, with evidence drawn from randomised controlled trials, cohort studies, and the most recent consensus guidelines.

#### Sources and selection criteria

We searched Medline from 2002 to 2011 using the terms “primary hyperparathyroidism”, “diagnosis”, and “management of primary hyperparathyroidism”. We reviewed all relevant articles as well as the proceedings from …
Teenage Suicide Clusters
Authors: Madelyn S. Gould
Journal: JAMA (1990)

To the Editor.—  Davidson et al1recently concluded that direct or indirect exposure to suicide was not associated significantly with suicide. However, the nature of the control group employed in their study limits the examination of the association of suicide with exposure to suicide as a risk factor. Given the amount of media coverage that surrounded the suicide clusters under study, the control group was inevitably exposed to the reports of the suicide cases. Indeed, the control subjects had a greater opportunity than the case subjects to be exposed to suicide stories that occurred during and after the cluster because the controls, by definition, survived the entire period of the cluster, whereas the case subjects obviously did not. This likelihood is highlighted in the finding that the case subjects werelesslikely than the control teenagers to have talked about death or suicide. Unless the identical assessment period
Direct Cardiovascular Implications of Emerging Infectious Diseases and Biological Terrorism Threats
Authors: Larry M. Baddour, Zhi Jie Zheng, Darwin R. Labarthe, Siobhán O'Connor
Journal: Circulation (2007)

Anthrax (Bacillus anthracis)Cutaneous anthrax: About 95% of anthrax infections occur through a cut or abrasion on the skin.The skin infection begins as a raised itchy bump but within 1-2 days develops into a vesicle and then a painless ulcer, usually 1-3 cm in diameter, with a characteristic black necrotic (dying) area in the center.About 20% of untreated cases of cutaneous anthrax result in death.Inhalational anthrax: Initial symptoms may resemble those of the common cold-sore throat, mild fever, muscle aches, and malaise.After several days, the symptoms may progress to severe breathing problems and shock.Inhalation anthrax is usually fatal.Gastrointestinal anthrax: Gastrointestinal anthrax is characterized by acute inflammation of the intestinal tract.Initial signs of nausea, loss of appetite, vomiting, and fever are followed by abdominal pain, vomiting of blood, and severe diarrhea.Intestinal anthrax results in death in 25%-60% of affected individuals.Anthrax is diagnosed by isolating B. anthracis from the blood, skin lesions, or respiratory secretions or by measuring certain antibodies in the blood.Health care providers should confirm the diagnosis by obtaining the appropriate laboratory specimens based on the clinical form of the suspected anthrax: specimens of vesicular fluid and blood for cutaneous anthrax, blood and cerebrospinal fluid (if meningeal signs are present) or chest X-ray for inhalational anthrax, and blood for gastrointestinal anthrax.Botulism (Clostridium botulinum toxin) The classic symptoms of botulism include double vision, blurred vision, drooping eyelids, slurred speech, difficulty swallowing, dry mouth, and muscle weakness.Infants with botulism appear lethargic, feed poorly, are constipated, and have a weak cry and poor muscle tone.These are all symptoms of the muscle paralysis caused by the bacterial toxin.If untreated, these symptoms may progress to cause paralysis of the arms, legs, trunk, and respiratory muscles.In foodborne botulism, symptoms generally begin 18-36 h after eating a contaminated food, but they can occur as early as 6 h or as late as 10 days later.
A key medical decision maker: the patient
Authors: R. A Deyo
Journal: BMJ (2001)

Primary care pp 490, 493 

Many medical decisions fall into a grey area where the optimal choice for an individual patient may be unclear and where reasonable people might choose differently. Common examples include elective surgical procedures, such as lumbar discectomy or resection for benign prostatic hypertrophy. Drug treatment may pose similar choices when treatment offers both appreciable benefits and appreciable risks. Hormone replacement therapy in postmenopausal women is an example, as is anticoagulant therapy in patients with non-valvular atrial fibrillation. Decisions about such treatments are made daily in clinical practice, and there is considerable evidence that patients want more information and greater involvement in them. In general we do a poor job of providing information, though this week's BMJ includes studies of two examples of a new generation of interactive methods of patient information that holds promise of improvement. 1 2

Although physicians often describe the nature of decisions to their patients, they less often discuss risks and benefits and rarely assess patient understanding.3 Though invasive procedures require “informed consent,” it usually takes the form of seeking patient agreement with a recommendation, rather than quantifying the risks and benefits …
Association between Psychoneurosis and Thyroid, Musculoskeletal and Intestinal Disorders in Four Agricultural Collective Settlements in Israel
Authors: Naphtali Brand
Journal: Psychotherapy and Psychosomatics (1965)

Research Articles| February 11 2010 Association between Psychoneurosis and Thyroid, Musculoskeletal and Intestinal Disorders in Four Agricultural Collective Settlements in Israel Subject Area: Psychiatry and Psychology Naphtali Brand Naphtali Brand Worker's Sick Fund, Dan Search for other works by this author on: This Site PubMed Google Scholar Psychother Psychosom (1965) 13 (6): 410–420. https://doi.org/10.1159/000285801 Article history Published Online: February 11 2010 Content Tools Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Facebook Twitter LinkedIn Email Tools Icon Tools Get Permissions Cite Icon Cite Search Site Citation Naphtali Brand; Association between Psychoneurosis and Thyroid, Musculoskeletal and Intestinal Disorders in Four Agricultural Collective Settlements in Israel. Psychother Psychosom 1 June 1965; 13 (6): 410–420. https://doi.org/10.1159/000285801 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAll JournalsPsychotherapy and Psychosomatics Search Advanced Search This content is only available via PDF. 1965Copyright / Drug Dosage / DisclaimerCopyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher.Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. Article PDF first page preview Close Modal You do not currently have access to this content.
Contact urticaria due to p-chloro-m-cresol
Authors: S.L. Walker, R.J.G. Chalmers, M.H. Beck
Journal: British Journal of Dermatology (2004)

Sir, A 42‐year‐old woman with psoriasis since the age of 7 was referred to the Contact Dermatitis Investigation Unit because of a clear history of severe pruritus and redness occurring within 30 min of applying certain topical preparations including emollients and corticosteroids creams. She was also aware that perfumes and some cosmetics would induce a similar sensation. She found this distressing and disabling. Our standard series, face series and her own medicaments and cosmetics were applied in the usual way but left in place for only 30 min. On removal there were marked urticarial reactions to fragrance mix, cinnamaldehyde, eugenol and p‐chloro‐m‐cresol. There were also marked urticarial reactions to all those medicaments which contained p‐chloro‐m‐cresol and that had been prescribed for her psoriasis (Fig. 1). These were Diprobase®, Betnovate® and Eumovate® creams and a brand of aqueous cream containing p‐chloro‐m‐cresol. The mechanisms producing contact urticaria are immunological, where there is a Type 1 hypersensitivity reaction caused by an allergen‐specific IgE, or nonimmunological, in which a substance may cause the release of factors which produce urticaria in virtually all exposed individuals. In some cases a combination of these two mechanisms occurs giving rise to a third ‘mixed’ or uncertain category, e.g. those caused by ammonium persulphate.
An Agranulocytic Blood Picture with a Pneumococcic Septicemia
Authors: SHERBURNE CAMPBELL
Journal: Annals of Internal Medicine (1931)

Article1 April 1931An Agranulocytic Blood Picture with a Pneumococcic SepticemiaSHERBURNE CAMPBELL, M. D., THOMAS P. MURDOCK, M. D., F. A. C. P.SHERBURNE CAMPBELL, M. D.Search for more papers by this author, THOMAS P. MURDOCK, M. D., F. A. C. P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-4-10-1333 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptAvoluminous literature has developed on the subject of agranulocytic angina since Schultz1 first described the condition in 1922. Most of the cases reported to date have been the so-called pure cases in which the blood picture was that of an agranulocytosis, without complication, and without an associated incidental condition.Turk2 has reported a case in which there seemed to be a very definite connection between the sepsis of the lip and mouth, and the blood picture. The organism from the pus was staphylococcus aureus.Blumer3reports the observation of four cases and reported one. In this case there was present...References1 SCHUTZ W: Ueber eigenartige Halserkrankungen. Deutsche med. Wchnschr., November 3rd, 1922. Google Scholar2 TURK W: Septische Erkrankungen bei Verkummerung des Granulozytensystems. Wien. klin. Wchnschr., 20: 157-163, 1907. Google Scholar3 BLUMER G: American Journal of the Medical Sciences, Vol. 159, 1930. Google Scholar4 ALLEN W: Annals of Internal Medicine. 2:542, Dec. 1928. LinkGoogle Scholar5 KASTLIN GJ: American Journal of the Medical Sciences, June 1927. Google Scholar6 HUTCHESON JM: Annals of Internal Medicine, Vol. 3, 904: March, 1930. LinkGoogle Scholar7 HUEPER WC: Archives of Internal Medicine, December, 1928. Google Scholar8 ROBERTSKRACHE SRRR: Journal of the American Medical Association, Vol. 95, 780, No. 11, September 13th, 1930. CrossrefGoogle Scholar9 BABBITTFITZ-HUGHS : Archives of Otolaryngology, Vol. 12, p. 439, October, 1930. CrossrefGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Meriden, Conn. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 April 1931Volume 4, Issue 10Page: 1333-1335KeywordsAnginaBloodMouthRisk managementSepsisStaphylococcus aureus Issue Published: 1 April 1931 PDF downloadLoading ...
Gastric mucosal blood flow and acid secretory changes in man with impromidine: a new specific histamine-H2-receptor agonist.
Authors: R L McIsaac, B J Johnston, L P Fielding
Journal: Gut (1981)

The effect of impromidine, a new histamine-H2-receptor agonist, on gastric mucosal blood flow (neutral red clearance) and acid secretion was studied in nine volunteers. Impromidine stimulated a dose-dependent increase in neutral red clearance and acid secretion. Simultaneous cimetidine in three doses caused a parallel shift to the right for both acid output and clearance with unchanged maxima compatible with simple surmountable antagonism. There were small cardiovascular changes: an increased heart rate with a decreased diastolic pressure during infusion of impromidine. These changes were antagonised by cimetidine.
Acute cholecystitis and thiazides.
Authors: W Van der Linden, B Ritter, G Edlund
Journal: BMJ (1984)

Drugs purchased by a random sample (17 000) of the population of Jämtland county, Sweden, are continuously monitored. Patients who had been admitted to the county9s only hospital with acute cholecystitis and who were part of this sample were studied, and controls matched for age and sex were drawn from the sample. The purchase of thiazides and other drugs prescribed to the patients with acute cholecystitis was compared with that of the controls. The estimated relative risk of developing acute cholecystitis in patients who had purchased thiazides in the year before admission to hospital, as compared with those who had not, was 2.1 (95% confidence limit 1.1-3.9). As it has been reliably reported that the use of thiazides is not itself associated with cholelithiasis, the association found between thiazides and cholecystitis suggests that thiazides may increase the risk of acute cholecystitis developing in a patient with gall stones.
Inhibition of Catecholamine Biosynthesis in Man
Authors: KARL ENGELMAN, ALBERT SJOERDSMA
Journal: Circulation Research (1966)

Reduction of catecholamine synthesis by as much as 70% has been achieved in man with the oral administration of a-methyl-para-Ltyrosine, a tyrosine hydroxylase inhibitor. Significant reduction of blood pressure and improvement of the general clinical status have been achieved in patients with pheochromocytoma. However, at the doses employed, no significant blood pressure effects were noted in patients with essential hypertension.
Sunburn and melanoma
Authors: S A Will, C B J Woodman
Journal: BMJ (1994)

EDITOR, - Robin Marks and David Whiteman raise two interesting points in their editorial on the link between sunburn and melanoma - namely, that recall as a measure of assessing the prevalence and severity of sunburn is unreliable and that there is a possibility that the risk associated with sunburn is not constant throughout life but is more important …
Cystic Fibrosis and Infections
Authors: Joan Stephenson
Journal: JAMA (2008)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Alcohol consumption during pregnancy and infants' development.
Authors: M M Madlom
Journal: BMJ (1991)

Alcohol consumption during pregnancy and infants' development SIR,-In their study Dr F Forrest and colleagues tried to find a relation between alcohol intake during pregnancy and infants' development.'Other factors, however, had to be taken into consideration, such as maternal smoking.Using the Bayley scales of infant development, the authors showed that the mental index was lower (-6 units) for children whose mothers smoked 10-19 cigarettes a day and (-3 units) for those whose mothers smoked .'20cigarettes a day.What I would have liked to know is the clinical importance or consequence of this lower score and whether a child with the lower score is within or outside the normal range for age.If she or he is