tbuckley/cabot-search huggingface dataset:
Relation of arteriographically defined coronary artery disease to serum lipoprotein particles mapped with monoclonal antibodies.
Authors: C Fiévet, M C Nuttens, P Ducimetière, J C Fruchart, M Bertrand, J L Salomez
Journal: Circulation (1991)

This study was designed to investigate the relation of a molecular analysis of apolipoprotein B (apoB)-containing atherogenic lipoprotein particles to coronary artery disease (CAD) in middle-aged men.Two groups of men were studied. The first consisted of 97 patients with angiographically documented CAD (greater than 50% stenosis of at least one coronary artery). The second group consisted of 145 subjects without symptomatic CAD, who served as controls. In both groups, measurements were obtained for total cholesterol level, triglyceride level, cholesterol contents in apoB- and nonapoB-containing particles (LpB, LpnonB), total apoB and apolipoprotein AI (apoAI levels), lipoprotein particles recognized by monoclonal antibodies anti-apoB (LpBL3, LpBL5, LpBL7) and anti-apoAI (LpAI-2GII). Taking into account age, body mass index, hypertension, diabetes, smoking habits, and drug consumption, the analysis showed that the mean levels of cholesterol were identical in both groups but differed when cholesterol content in LpB and LpnonB subfractions were assessed, thus reflecting an increase in the low density fraction and a decrease in the high density fraction, respectively. This was confirmed by an increase in total apoB and a decrease in total apoAI. Measurements of LpBL3, LpBL5, LpBL7, and LpAI-2GII particles also discriminated between the two groups. After adjustment for cholesterol content in LpnonB particles, a difference in total apoB was no longer significant between groups, whereas LpBL3, LpBL5, and LpBL7 levels remained significantly higher in CAD patients.The measurement of separate concentrations of apoB in different particles may permit a more-accurate assessment of CAD risk than measurements of total apoB levels.
LEAD AND SILVER IN URINARY CALCULI
Authors: Victor C. Jacobsen
Journal: JAMA (1941)

<h3>To the Editor:—</h3> InThe Journal, July 5, 1941, page 20, Francis Carter Wood reported on studies he had made of the incidence of lead in urinary calculi. He drew attention to the finding by Trumper and Gordy (The Journal, March 29, 1941, p. 1389) of 3 per cent of lead in a phosphatic ureteral calculus while the urine contained lead in so-called normal amount. Dr. Wood compared the lead content of urinary stones of the vintage 1850-1860, examining 20, all of which contained lead, thus disproving any deduction that ethyl-lead gasoline necessarily accounts for increased lead output in the urine today. He also mentioned the fact that traces of copper and silver were regularly present, as well as other metals. At a meeting of the Pathological Society of Eastern New York, Dec. 9, 1932, Dr. Gustavus H. Klinck Jr. (<i>Arch. Path.</i><b>15</b>:751 [May],<b>16</b>:598 [Oct.] 1933), then
Carcinoma of the Parathyroid Glands
Authors: Benjamin A. Barnes
Journal: JAMA (1961)

THE ENTITY of carcinoma of the parathyroid glands is well established in the medical literature in spite of its extreme rarity. This condition, particularly when associated with a tumor of endocrine function, is a fascinating and intriguing one from the physiological point of view. More important, it represents a condition which is fraught with hazards to the patient and one which is a challenge to the surgeon inasmuch as surgical therapy is the only method available to achieve a cure. Experience at this hospital has included 10 cases of functioning carcinomas in over 250 cases of hyperfunctioning tumors of the parathyroid glands. Although 4 of these cases have been presented by us, it is desirable at this time to review the entire experience with 6 additional cases. Recently our attention has been directed to errors in diagnosis that have resulted in unsatisfactory treatment. We wish to emphasize again that the
Ultrastructural observations on the effect of azelaic acid on normal human melanocytes and a human melanoma cell line in tissue culture
Authors: E.J. ROBINS, A.S. BREATHNACH, D. BENNETT, B.J. WARD, Y. BHASIN, L. ETHRIDGE, M. NAZZARO-PORRO, S. PASSI, M. PICARDO
Journal: British Journal of Dermatology (1985)

Journal Article Ultrastructural observations on the effect of azelaic acid on normal human melanocytes and a human melanoma cell line in tissue culture Get access E.J. ROBINS, E.J. ROBINS Departments of Anatomy, St Mary's Search for other works by this author on: Oxford Academic Google Scholar A.S. BREATHNACH, A.S. BREATHNACH Departments of Anatomy, St Mary's Professor A.S.Breathnach, Department of Anatomy, St Mary's Hospital Medical School, Norfolk Place, London W2, U.K. Search for other works by this author on: Oxford Academic Google Scholar D. BENNETT, D. BENNETT St George's Hospital Medical Schools, London Search for other works by this author on: Oxford Academic Google Scholar B.J. WARD, B.J. WARD Departments of Anatomy, St Mary's Search for other works by this author on: Oxford Academic Google Scholar Y. BHASIN, Y. BHASIN Departments of Anatomy, St Mary's Search for other works by this author on: Oxford Academic Google Scholar L. ETHRIDGE, L. ETHRIDGE Departments of Anatomy, St Mary's Search for other works by this author on: Oxford Academic Google Scholar M. NAZZARO‐PORRO, M. NAZZARO‐PORRO Instituto Dermatologico, San Gallicano, Rome, Italy Search for other works by this author on: Oxford Academic Google Scholar S. PASSI, S. PASSI Instituto Dermatologico, San Gallicano, Rome, Italy Search for other works by this author on: Oxford Academic Google Scholar M. PICARDO M. PICARDO Instituto Dermatologico, San Gallicano, Rome, Italy Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 113, Issue 6, 1 December 1985, Pages 687–697, https://doi.org/10.1111/j.1365-2133.1985.tb02404.x Published: 01 December 1985 Article history Accepted: 15 May 1985 Published: 01 December 1985
ADAPTATION OF THOMAS AND JONES SPLINTS TO OBTAIN FIXATION OF THE ARM IN AN ABDUCTED POSITION WHILE THE PATIENT IS AMBULATORY
Authors: R. B. Osgood
Journal: BMJ (1917)

Bzm? 477 III.|To a tube of peptone water add 3 to 10 drops of polyvalent 7R.coli, B.pseudo-coli, B. coli tropicalis, B. neapolitanus serum, or 3 to 5 drops of each Qf the respective mono-serums.Inoculate with B. coli, B. pseilu-coli, B. coli tropicalis, B. neapolitanu-s, and shake well.Incubate at 370 C., and( examine after twelve hours;.the medium will be clear.Repeat the experiment, itioculating the medium with the same bacteria plus V. choleacae, and examine after twelve hours' incuibation at 373 C.; the medium will show diffuse cloudiness, often more marked towards the surface (and at times a pellicle), klue to the growth of the cholera vibrio, whiclh has not been influenced by the seruims added.Care of course should be taken to use serurms containing no cholera coagglutiniin, or only in minute amount.Actioni of Non-specific Agglutinins. I.Add to a peptone water tube 3 to 5 drops of a very powerful figglutinating paratyphoid B sernm, rich in specific and non- apecifi agglutiiiins.Inoculate the tube with B. typhostus, B. paratyphosits A, B. paratyphosus B, B. aertrycke, B. euiteritidis (Gaertner), and examine after twelve hours; there will be no homogeneous growth, and no diffuse turbidity.The growth is at the bottom, and at times under the form of flocculi in the nedium, which will quickly go to the bottom on cenitrifuging.If, instead of a very powerful agglutinating paratyphoid B serum, one of low titre is used, containing onlv a verv small amotunt of coagglutiniins, the mediuim will show a diffuse turbidity, due to tlle growth of the B. typhosuts, B. para- typhosus A, B. enteritidis, while bottom growth and tlocculi will be present, composed of agglutinated paratyphoid B bacilli, and also aertrycke bacillus, because genierallv any paratyphoid B serum contains nearly as much agglutinin for B. aiertryckve as for B. paratyphosuts.These two bacteria can be differentiated onlv by my absorption method, as demonstrated by Boycott, Bainbridge; O'Brieni, and others. II.Add to a tube of peptonie water 3 to 5 dlops of a very power- futl agglutinating paratyphoid B serum containing coagglutinins for the typhoid-paratyphoid group of micro-organisms.Inoculate with B. typlhosus, B. paratyphlosus A, B. para- typhosus B, B. aertrycke, I. cholerae.Inoculate at 370 C., and 5examine after twelve houirs.There will be diffuise turbiditv, due to the growth of the 1. cholerce, and flocculi and bottom growth due to the typhoid, paratyphoid, and aertrycke germs; the flocculi may easily be got rid of by a short centrifugation which will have nio effect whatever on the non-agglutinated cholera vibrios.After a few hours longer there may be a distinct pellicle composed of vibrios.Of course, in carrying out this experiment, care should )be taken to use a paratyphoid B serum which contains no coagglutilnin for I=.cholei-e, or only in very small amount.'
ACUTE ENDOCARDITIS IN CHILDREN.Read in the Section on Diseases of Children, at the Forty-fourth Annual Meeting of the American Medical Association.
Authors: GEORGE N. HIGHLEY
Journal: JAMA (1894)

ETIOLOGY. From a practical point of view, we can not look upon acute endocarditis as an idiopathic disease; if it ever occurs as such, it has been so rarely recognized that its existence in that form seems more than doubtful. Causes like cold, etc., which seem so prolific in producing inflammation of other similar structures,—as for instance the other serous and the mucous membranes—apparently have little direct influence in setting up inflammation of the inner lining of the heart. This immunity may be due to its situation, but it is difficult to assign a cause for it. This escape from primary affection is more than counter-balanced by the frequency with which the membrane is affected through the agency of other diseases—due wholly to the pathologic condition of the blood which those diseases create. The pathologic state which we call rheumatism is responsible for the largest number of cases of endocarditis.
Comparison of two methods for exhaled breath condensate collection
Authors: O. U. Soyer, E. A. Dizdar, O. Keskin, C. Lilly, O. Kalayci
Journal: Allergy (2006)

Background: Exhaled breath condensate (EBC) is a noninvasive method to obtain samples from fluids lining the respiratory surfaces. Even though various methods and devices are now available, the relative efficiency of these methods for recovering airway mediators and characterizing EBC has not been established. Aim: To compare the volume, pH, lipid mediator, and protein concentrations in EBCs collected by two commonly used commercially available devices, RTube TM and ECoScreen. Methods: Exhaled breath condensates were obtained consecutively using the RTube TM and ECoScreen methods from 30 healthy, nonallergic adults. Samples were immediately placed on dry ice after collection. pH was measured after argon deaeration. Cysteinyl leukotrienes (cys‐LTs) were measured as a representative lipid mediator and eotaxin as the protein mediator by using enzyme‐linked immunosorbent assay. Results: The mean volume of samples obtained with ECoScreen (1880 ± 116 μ l) was significantly higher than that obtained with RTube TM (1405 ± 82 μ l) ( P &lt; 0.001). Concentrations of both cys‐LTs [205.4 pg/ml (65.5–472.3) with ECoScreen vs 21.6 (11.87–152.2) with RTube TM , P &lt; 0.001] and eotaxin [17.0 pg/ml (11.4–22.4) with ECoScreen vs 11.7 (10.5–13.5) with RTube TM , P = 0.01] were significantly higher in samples collected with ECoScreen than with RTube TM . There was no significant difference between the pH measurements. Conclusion: Compared with RTube TM , collection of exhaled breath by ECoScreen allows larger volumes to be collected and detects protein and lipid mediators with greater sensitivity. These differences in mediator recovery may be due to the differences in the collection temperature.
More on Alternative Medicine
Authors: Michael J. Sergeant
Journal: Annals of Internal Medicine (2000)

Letters18 April 2000More on Alternative MedicineMichael J. Sergeant, MDMichael J. Sergeant, MDNeurology, Ltd.; Kankakee, IL 60901 (Sergeant)Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-132-8-200004180-00013 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:I found the exchange of letters on alternative medicine (1-5) fascinating. I, too, believe that the reason people seek alternative medicine has nothing to do with how well it works, with the perception that the practitioners spend more time, or with its position as the latest fad. I, too, believe that people choose alternative medicine for the same reason people turn to religions, cults, psychics, and faith healers.It harkens back to how fragile life is. Everyone is one heartbeat away from death. In the blink of an eyelash, we will all be sick, alone, dead, and ...References1. Bagley CM. Alternative views on alternative medicine [Letter]. Ann Intern Med. 1999;131:229. LinkGoogle Scholar2. Shaughnessy AF. Alternative views on alternative medicine [Letter]. Ann Intern Med. 1999;131:229. LinkGoogle Scholar3. Ganguly A. Alternative views on alternative medicine [Letter]. Ann Intern Med. 1999;131:229-30. LinkGoogle Scholar4. Ernst E. Alternative views on alternative medicine [Letter]. Ann Intern Med. 1999;131:230. LinkGoogle Scholar5. Kaptchuk TJ, Eisenberg DM. Alternative views on alternative medicine [Letter]. Ann Intern Med. 1999;131:230. LinkGoogle Scholar Author, Article, and Disclosure InformationAffiliations: Neurology, Ltd.; Kankakee, IL 60901 (Sergeant) PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoAlternative Views on Alternative Medicine Charles M. Bagley Jr. Alternative Views on Alternative Medicine Allen F. Shaughnessy Alternative Views on Alternative Medicine Arunabha Ganguly Alternative Views on Alternative Medicine Edzard Ernst Alternative Views on Alternative Medicine Ted J. Kaptchuk and David M. Eisenberg More on Alternative Medicine Ted J. Kaptchuk Metrics Cited ByVarieties of Healing. 1: Medical Pluralism in the United StatesTed J. Kaptchuk, OMD and David M. Eisenberg, MD 18 April 2000Volume 132, Issue 8Page: 675KeywordsDeceptionForecastingPerceptionScientists Issue Published: 18 April 2000 CopyrightCopyright © 2000 by American College of Physicians. All Rights Reserved.PDF DownloadLoading ...
Diagnosis of Upper Gastrointestinal Tract Hemorrhage
Authors: Robert A. Baird
Journal: JAMA (1970)

<h3>To the Editor.—</h3> Zollinger and Nick (<b>212</b>:2251, 1970) state that, "If the site of bleeding cannot be located by roentgenographic methods... endoscopy may be successful in demonstrating bleeding." Apparently they depend predominantly upon the former. Roentgenographic examination has two weaknesses in the diagnosis of upper gastrointestinal tract (UGI) hemorrhage. The first is the failure to visualize potentially bleeding lesions such as erosive gastritis and esophagitis. Before the advent of gastroscopy, erosive gastritis was thought to occur in only 2% of UGI hemorrhages. With the use of gastroscopy this entity can be shown to be the cause of bleeding in 12.5% to 20% of UGI hemorrhages.<sup>1,2</sup>Similarly, erosive esophagitis is now found in 6% of cases that undergo endoscopy.<sup>1</sup>The second weakness is the inability to demonstrate whether or not a roentgenographically visible lesion is the site of active bleeding. In a series of 1,400 cases diagnosed endoscopically and
O62 SOFOSBUVIR COMPASSIONATE USE PROGRAM FOR PATIENTS WITH SEVERE RECURRENT HEPATITIS C INCLUDING FIBROSING CHOLESTATIC HEPATITIS FOLLOWING LIVER TRANSPLANTATION
Authors: X. Forns, M. Prieto, M. Charlton, J.G. McHutchison, W.T. Symonds, J. Denning, T. Brandt-Sarif, P. Chang, V. Kivett, R.J. Fontana, T.F. Baumert, A. Coilly, L. Castells, F. Habersetzer
Journal: Journal of Hepatology (2014)
A dosimeter for long wave ultraviolet radiation
Authors: B.L. DIFFEY, A. DAVIS, M. JOHNSON, T.R. HARRINGTON
Journal: British Journal of Dermatology (1977)

A polymer film, which incorporates phenothiazine as the chromophore, has been developed as a personnel dosimeter for long wave ultraviolet radiation. It is stable, reproducible and is particularly suited to monitoring the doses received by patients undergoing photochemotherapy for psoriasis.
The Journal Abstracts.
Authors: Wilfred Taylor
Journal: JAMA (1902)

Dayton, Ohio, March 4, 1902. <h3>To the Editor:</h3> —Anent your editorial on "abstracts" in issue of March 1, p. 587, permit me to say that to this member of the profession they are an<i>extremely</i>valuable addition. While the papers of the Association and the original communications may or may not strike my fancy, the abstracts always contain something of interest to me. Do not give up the abstracts. Respectfully,
Monkeying around with cardiac progenitors: hope for the future
Authors: Li Qian, Deepak Srivastava
Journal: Journal of Clinical Investigation (2010)

Multipotent cardiovascular progenitor cells derived from ES cells or induced pluripotent stem (iPS) cells are an intriguing source for stem cell–based therapies for congenital and acquired heart diseases. From a clinical perspective, the ideal cardiac progenitor cells are those that can proliferate, survive, and differentiate into multiple mature cardiac cell types when transplanted into normal or diseased heart. In this issue of JCI, Blin et al. report the isolation and characterization of a group of early mesodermal cardiovascular progenitor cells, induced by BMP2 and marked by the cell surface protein, stage-specific embryonic antigen 1 (SSEA-1). BMP2-induced SSEA-1+ cells were purified from ES and iPS cells and could be directed to differentiate into cardiomyocytes, endothelial cells, and smooth muscle cells by treatment with defined cytokines and signaling molecules. Most importantly, purified SSEA+ progenitor cells from Rhesus monkey ES cells engrafted into nonhuman primate hearts, in which they differentiated into cardiac cells without forming teratomas. These findings move the field another step closer to clinical use of ES or iPS cell–derived cardiovascular progenitors in cardiac repair.
Case 30-1966
Authors: William B. Bean, Louis N. Katz
Journal: New England Journal of Medicine (1966)

Presentation of Case*A forty-two-year-old woman was admitted to the hospital because of ecchymoses.She had been well until the development of wheezing four weeks previously; an antiasthmatic (Tedral) and penicillin were administered but afforded no relief. An x-ray film of the chest disclosed a large aortic aneurysm. One week before admission diarrhea and ankle edema occurred, and five days later she entered another hospital. On the following day ecchymoses appeared, and on the next morning the potassium was 6.5 milliequiv. per liter.Three years earlier she had experienced the abrupt onset of severe pain in both sides of the . . .
Reducing risks of tourniquets left on after finger and toe surgery: summary of a safety report from the National Patient Safety Agency
Authors: T. Lamont, F. Watts, J. Stanley, J. Scarpello, S. Panesar
Journal: BMJ (2010)

Tourniquets are used in hand and foot surgery because of the need for a bloodless field to allow for careful dissection. They are used in a range of settings, such as operating theatres, emergency departments, community sites (for example, for minor surgery in podiatry clinics). Although rare, complications can lead to serious harm, including, at worst, irreversible ischaemia.

Between August 2005 and November 2009, healthcare staff in England and Wales reported 15 serious incidents in which tourniquets had been left on fingers or toes by mistake. Ten patients needed further surgery and two incidents resulted in amputation. At least six of the incidents related to surgical gloves being used as tourniquets. Fourteen litigation claims relating to tourniquets were also reported in this period.

A typical incident report reads: “Patient had termination of tip of right ring finger. He attended plastic dressing clinic for routine follow up. When the dressing was removed, his ring finger was necrotic and still had what looked like a glove tourniquet in situ. Explained to patient he will require …
Oncolysis of hepatic metastasis of colorectal cancer by recombinant vesicular stomatitis virus in immune-competent mice
Authors: Tian-Gui Huang, Oliver Ebert, Katsunori Shinozaki, Adolfo García-Sastre, Savio L.C Woo
Journal: Molecular Therapy (2003)

With currently available treatments, patients with metastatic colorectal cancer (CRC) have a median survival of 14.8 months and a 5-year survival rate of less than 10%. In recent years, tumor-targeted replicating viruses have rapidly emerged as potential novel oncolytic agents for cancer treatment. Vesicular stomatitis virus (VSV) is a negative-strand RNA virus with inherent selectivity for replication in tumor cells due to their attenuated antiviral response. VSV is particularly appealing as an oncolytic agent for its exceptionally rapid replication cycle in tumor cells, whereby it is capable of manifesting its maximal oncolytic effects before the onset of neutralizing antiviral immune responses in the host. In this study, we used a recombinant VSV vector expressing the green fluorescent protein gene (rVSV-GFP) to monitor VSV replication easily in CRC cells. Using this GFP-expressing virus, we found that rVSV-GFP efficiently replicated and lysed murine and human CRC cell lines in vitro. We also evaluated the potential of rVSV-GFP to treat MCA26 CRC metastases implanted orthotopically into the livers of syngeneic BALB/c mice. We provide conclusive evidence that rVSV-GFP is able to replicate extensively in the tumors, but not in normal liver cells, in tumor-bearing mice. A single intratumoral injection also caused extensive tumor necrosis, which led to a significant prolongation of animal survival. Our results indicate that VSV can be an effective and safe oncolytic agent against hepatic CRC metastasis in immune-competent mice and may be developed for the treatment of cancer patients in the future.
Foreign Medical Graduates in the United States-Reply
Authors: Thomas W. Mou
Journal: JAMA (1987)

<h3>In Reply.—</h3> Dr Khera is correct in saying that foreign physicians found it relatively easy to come to the United States a few years ago and that only a small number of foreign medical graduates can find residency opportunities today in our relatively rigidly organized education programs. The FMGEMS was a necessary development to address former inequities. The approximate pass rate fluctuates between 25% and 30%. Our clinical skills test pilot study is part of the broad issue of testing clinical skills in all medical school graduates, an issue that will require further discussion in the coming months. The principal focus of our comments concerned an expanded exchange visitor program that would provide more educational opportunities in the United States for foreign medical graduates, with a clear understanding that the individual must return to his or her home country and contribute to the improvement of health care in that country.
The effect of RGD density on osteoblast and endothelial cell behavior on RGD-grafted polyethylene terephthalate surfaces
Authors: Celine Chollet, Christel Chanseau, Murielle Remy, Alain Guignandon, Reine Bareille, Christine Labrugère, Laurence Bordenave, Marie-C. Durrieu
Journal: Biomaterials (2008)
Serum ratio of γ-GT/ALT activity rather than ISDR variability is predictive for virological responsiveness to IFN-α therapy in patients infected by HCV genotypes 1A, 1B, and 3A
Authors: S. Mihm, M. Monazahian, S. Grethe, Ch. Fechner, G. Ramadori, R. Thomssen
Journal: Journal of Hepatology (1998)