ISLET-CELL TUMORS AND PEPTIC ULCERS: CASE REPORT OF THE ZOLLINGER-ELLISON SYNDROME
Authors: V E CHVOJKA
Journal: Annals of Internal Medicine (1960)

Article1 December 1960ISLET-CELL TUMORS AND PEPTIC ULCERS: CASE REPORT OF THE ZOLLINGER-ELLISON SYNDROMEVICTOR E. CHVOJKA, M.D.VICTOR E. CHVOJKA, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-53-6-1180 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptPancreatic endocrine function has long been suspect in gastroduodenal ulceration, although it has never been definitely and conclusively incriminated. The existence of an intrinsic factor of the pancreas that is not related to its external secretions but that may be active in peptic ulcerogenesis was postulated by Poth in 1948.1This concept was based on the earlier experimental observations of Dragstedt, Elman, Poth, and others that duodenal ulcers may be produced by deviation of the alkaline secretions of the pancreas by external fistulas or by ligation of the pancreatic ducts. These ulcers had usually been considered to be the result...Bibliography1. PothManhoffDeloach EJLJAW: The relation of pancreatic secretion to peptic ulcer formation, Surgery 24: 62, 1948. MedlineGoogle Scholar2. ElmanHartman RAF: Spontaneous peptic ulcers of the duodenum after continued loss of pancreatic juice, Arch. Surg. 23: 1030, 1931. CrossrefGoogle Scholar3. Dragstedt LR: Pathogenesis of the gastroduodenal ulcer, Arch. Surg. 44: 438, 1942. CrossrefGoogle Scholar4. ZollingerEllison RMEH: Primary peptic ulcerations of the jejunum associated with islet-cell tumors of the pancreas, Ann. Surg. 142: 709, 1955. CrossrefMedlineGoogle Scholar5. Ellison EH: The ulcerogenic tumor of the pancreas, Surgery 40: 147, 1956. MedlineGoogle Scholar6. Ellison EH: Personal communication. Google Scholar7. OberhelmanNelsenDragstedt HATSLR: Peptic ulcer associated with tumors of the pancreas, Arch. Surg. 77: 402, 1958. CrossrefGoogle Scholar8. JanowitzCrohn HDBB: Hyperinsulinism and duodenal ulcer: rare clinical combination, Gastroenterology 17: 578, 1951. CrossrefMedlineGoogle Scholar9. PothFromm EJSM: The relation of pancreatic secretion to peptic ulcer formation, Gastroenterology 16: 490, 1950. CrossrefMedlineGoogle Scholar10. SutherlandCori EWCF: Effect of hyperglycemic-glycogenolytic factor and epinephrine on liver phosphorylase, J. Biol. Chem. 188: 531, 1951. CrossrefMedlineGoogle Scholar11. Poth EJ: Unpublished data. Google Scholar12. Osborne MP: Personal communication. Google Scholar13. ZollingerMcPherson RMRC: Ulcerogenic tumors of the pancreas, Am. J. Surg. 95: 359, 1958. CrossrefMedlineGoogle Scholar14. Summerskill WH: Malabsorption and jejunal ulceration due to gastric hypersecretion with pancreatic islet-cell hyperplasia, Lancet 1: 120, 1959. CrossrefMedlineGoogle Scholar15. ZollingerElliott RMDW: Pancreatic endocrine function and peptic ulceration, Gastroenterology 37: 419, 1959. CrossrefGoogle Scholar16. PriestAlexander WMMR: Islet-cell tumor of the pancreas with peptic ulceration, diarrhea, and hypokalemia, Lancet 2: 1145, 1957. CrossrefGoogle Scholar17. Donaldsonvon EigenDwight RMPRRM: Gastric hypersecretion, peptic ulceration, and islet-cell tumor of the pancreas (the Zollinger-Ellison syndrome): report of a case and review of the literature, New England J. Med. 257: 965, 1957. CrossrefMedlineGoogle Scholar18. EvertBlackDockerty JAEMMB: Primary nonspecific ulcers of the small intestine, Surgery 23: 185, 1948. MedlineGoogle Scholar19. SampselBarry JWFM: Primary jejunal ulcer with recurrence following resection, Arch. Surg. 70: 420, 1955. CrossrefGoogle Scholar20. Oberhelman HA: Personal communication. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Galveston, Texas*Received for publication March 28, 1060.From the Department of Internal Medicine, University of Texas School of Medicine, Galveston, Texas.Requests for reprints should be addressed to Victor E. Chvojka, M.D., 333 East Huron Street, Chicago 11, Illinois. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byMultiple Endocrine Neoplasia Type 1 and Zollinger-Ellison SyndromeTumoren des PankreasZollinger-Ellison syndromeThe Zollinger Ellison Syndrome with SteatorrheaEFFECT OF HEXAMETHONIUM ON GASTRIC HYPERSECRETIONMalignant Zollinger-Ellison syndrome in a Bantu woman with a prolonged remission after gastric radiotherapyThe Zollinger-Ellison Syndrome. Its Place in the Pathophysiology of Gastric Acid Secretion and of its Hormonal RegulationA review of unusual systemic manifestations associated with carcinomaThe PancreasEndocrine Adenomatosis (Polyendocrine Disease) Familial OccurrencesDas Zollinger-Ellison-SyndromMedical genetics 1960 1 December 1960Volume 53, Issue 6Page: 1180-1195KeywordsDuodenal ulcersGastric ulcersLigation assayPancreasPancreatic ductsPeptic ulcersPernicious anemiaUlcersWeight gainZollinger Ellison syndrome ePublished: 1 December 2008 Issue Published: 1 December 1960 PDF downloadLoading ...