HEMOLYTIC JAUNDICE AND MACROCYTIC HEMOLYTIC ANEMIA: CERTAIN OBSERVATIONS IN A SERIES OF 35 CASES
Authors: Cecil James Watson
Journal: Annals of Internal Medicine (1939)

Article1 May 1939HEMOLYTIC JAUNDICE AND MACROCYTIC HEMOLYTIC ANEMIA: CERTAIN OBSERVATIONS IN A SERIES OF 35 CASESCECIL JAMES WATSON, M.D., Ph.D.CECIL JAMES WATSON, M.D., Ph.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-12-11-1782 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptDuring the past six years opportunity has been afforded to study 35 patients† exhibiting evidence of hemolytic anemia or jaundice. These cases were divided as follows:1. Microcytic (familial or congenital) type 202. Macrocytic (secondary or acquired) type 15a. With liver disease 8b. With Hodgkin's disease 3c. With leukemia 2d. With chronic bleeding into ovarian cyst 1e. With hyperthyroidism 1It will be noted that the cases in the second group were in all instances associated with other disease. The existence of a primary form of acquired hemolytic jaundice has been questioned more and...Bibliography1. EPPINGER H: Die hepato-lienalen Erkrankungen, 1920, J. Springer, Berlin. CrossrefGoogle Scholar2. WATSON CJ: Concerning the naturally occurring porphyrins. IV. The urinary porphyrin in lead poisoning as contrasted with that excreted normally and in other diseases, Jr. Clin. Invest., 1936, xv, 327. CrossrefGoogle Scholar3. WATSON CJ: (a) Studies of urobilinogen. I. An improved method for the quantitative estimation of urobilinogen in feces and urine, Am. Jr. Clin. Path., 1936, vi, 458. (b) Studies of urobilinogen. II. The per diem excretion of urobilinogen in urine and feces by normal individuals, and by patients having diseases not primarily affecting the liver or biliary tract, Arch. Int. Med., 1937, lix, 196. (c) Studies of urobilinogen. III. The per diem excretion of urobilinogen in the common forms of jaundice and disease of the liver, Arch. Int. Med., 1937, lix, 206. CrossrefGoogle Scholar4. BOCK HE: Über ein neues, einfaches Erythrocytenmessgerät für praktisch-klinische Zwecke (Erythrocytometer), Klin. Wchnschr., 1933, xii, 1141. CrossrefGoogle Scholar5. DOANCURTISWISEMAN CAGMBK: The hemolytopoietic equilibrium and emergency splenectomy, Jr. Am. Med. Assoc., 1935, cv, 1567. CrossrefGoogle Scholar6. LOVIBOND JL: Macrocytic hemolytic anemia. Report of a case, Lancet, 1935, ii, 1. Google Scholar7. DAWSON OF PENN.: Hume lectures on hemolytic jaundice, Brit. Med. Jr., 1931, i, 921. Google Scholar8. KREMERMASON MWH: Acholuric jaundice in the adult, Lancet, 1936, ii, 849. CrossrefGoogle Scholar9. WINTROBESHUMACKER MMHS: The occurrence of macrocytic anemia in association with disorder of the liver. Together with a consideration of the relation of this anemia to pernicious anemia, Bull. Johns Hopkins Hosp., 1933, lii, 387. Google Scholar10. ROSENBERG DH: Macrocytic anemia in liver disease, particularly cirrhosis. Observations on the incidence, course, and reticulocytosis, with a correlated study of the gastric acidity, Am. Jr. Med. Sci., 1936, cxcii, 86. CrossrefGoogle Scholar11. DAVIDSON LS: Macrocytic hemolytic anemia, Quart. Jr. Med., 1932, xxv, 543. Google Scholar12. HEILMEYER L: Blutfarbstoffwechselstudien. V. Mitteil. Der Farbstoffwechsel beim hämolytischen Ikterus und einigen hämolytischen Anämien verschiedener Genese. Wirkungen des Leberstoffs und peroral Milzverabreichung, Deutsch. Arch. f. klin. Med., 1932, clxxii, 628. Google Scholar13. GÄNSSLENZIPPLERLENSCHUZ MEE: Die hämolytische Konstitution, Deutsch. Arch. f. klin. Med., 1925, cxlvi, 1. Google Scholar14. HADEN RL(a) : The mechanism of the increased fragility of the erythrocytes in congenital hemolytic jaundice, Am. Jr. Med. Sci., 1934, clxxxvii, 441. (b) VAUGHAN, J. M.: Red cell characteristics in acholuric jaundice, Jr. Path. and Bact., 1937, xlv, 561. CrossrefGoogle Scholar15. WINTROBE MM: The size and hemoglobin content of the erythrocyte. Methods of determination and clinical application, Jr. Lab. and Clin. Med., 1932, xvii, 899. Google Scholar16. V. BOROS J: Die Behandlung der Anämien, Ergeb. d. inn. Med. u. Kinderheilk., 1932, xlii, 635. Google Scholar17. CHAUFFARD MA: Pathogenie de l'ictere congenital de l'adulte, Sem. Med., 1907, xxvii, 25. Google Scholar18. WIDALABRAMIBRULE FPM: Autoagglutination des hematies dans l'ictere hemolytique acquis., Soc. biol., 1908, lxiv, 655. Google Scholar19. MASTERSZERFASMETTEL JMLSHB: Congenital hemolytic icterus. Treatment with splenectomy; reports of two cases, Am. Jr. Dis. Child., 1929, xxxvii, 1254. CrossrefGoogle Scholar20. TILESTON W: Hemolytic jaundice, Medicine, 1922, i, 355. CrossrefGoogle Scholar21. CLOUGHRICHTER MCI: A study of an auto-agglutinin occurring in a human serum, Bull. Johns Hopkins Hosp., 1918, xxix, 86. Google Scholar22. KLIGLER IJ: Autohemo-agglutination of human red blood corpuscles, Jr. Am. Med. Assoc., 1922, lxxviii, 1195. Google Scholar23. REIMANN HA: Hyperproteinemia as a cause of autohemagglutination; observations in case of myeloma, Jr. Am. Med. Assoc., 1932, xcix, 1411. CrossrefGoogle Scholar24. FOORD AG: Hyperproteinemia, autohemagglutination, renal insufficiency and abnormal bleeding in multiple myeloma, ANN. INT. MED., 1935, viii, 1071. Google Scholar25. BARCROFT J: Recent knowledge of the spleen, Lancet, 1925, i, 318. Google Scholar26. DÜRR R: Banti Milz und hepatolienale Fibrose, Ziegler's Beitr., 1924, lxxii, 418. Google Scholar27. WATSON CJ: Histologic variations in diffuse splenic fibroses, Folia Haematol., 1929, xxxix, 102. Google Scholar28. WATSON CJ: The pyrrol pigments with particular reference to normal and pathological hemoglobin metabolism. In Downey's Handbook of Hematology, Paul B. Hoeber & Co., 1938, iv, Sec. 35, p. 2447. Google Scholar29. DAMESHEKSCHWARTZ WSO: The presence of hemolysins in acute hemolytic anemia, New Eng. Jr. Med., 1938, ccxviii, 75. CrossrefGoogle Scholar30. DAMESHEKSCHWARTZ WSO: Hemolysins as the cause of clinical and experimental hemolytic anemias, Am. Jr. Med. Sci., 1938, clxxxxvi, 769. CrossrefGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Minneapolis, Minnesota*Presented in part to the Minnesota State Medical Association, St. Paul, Minnesota, May 4, 1937. Received for publication May 19, 1938.From the Division of Internal Medicine, University of Minnesota Hospital, Minneapolis, Minnesota.Aided by a grant from the research fund of the Graduate School, University of Minnesota.†In somewhat more than a year since this paper was written, 13 additional instances of hemolytic anemia have been studied. Seven of these were typical cases of the familial, microcytic type, four were in association with leukemia, one was noted in a patient with cirrhosis of the liver, and another in a case of probable diffuse splenic fibrosis, or Banti's disease. The feces urobilinogen and reticulocyte percentage were elevated in varying degree in all of these cases. Of the four cases of leukemia, the anemia was macrocytic in three as judged by mean corpuscular volume and mean diameter of the erythrocytes. Measurements were not recorded in the fourth. It is of interest that two of these four cases were instances of subleukemic, splenic reticuloendotheliosis. Outspoken macrocytosis was present in the two patients with cirrhosis, and with Banti's disease. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byAnemia hemolítica autoinmunitaria asociada a quiste benigno de ovarioClassification and Clinical Characteristics of Autoimmune Hemolytic AnemiasCase 24-1978Responses of the isolated, perfused human spleen to sympathetic nerve stimulation, catecholamines and polypeptidesHemolytic anemia associated with an ovarian tumorDie hämolytischen AnämienAutoimmune Hemolytic Anemia as the Herald State of Hodgkin's DiseaseA. J. BOWDLER, M.D., I. W. GLICK, M.B.Correlation of Folate Deficiency with Alcoholism and Associated Macrocytosis, Anemia, and Liver DiseaseVICTOR HERBERT, M.D., RALPH ZALUSKY, M.D., CHARLES S. DAVIDSON, M.D., F.A.C.P.Spätfolgen der Virus-HepatitisJaundice in Hodgkin's diseaseAnemia of Hepatic Disease Studied with RadiochromiumSerologie und Klinik der autoimmunhämolytischen ErkrankungenACUTE ACQUIRED HEMOLYTIC ANEMIA IN ASSOCIATION WITH ACUTE VIRAL HEPATITIS*EDWARD C. RAFFENSPERGER, M.D., F.A.C.P.AUTO-IMMUNE HEMOLYTIC ANEMIA ARRESTED BY REMOVAL OF AN OVARIAN TERATOMA: REVIEW OF THE LITERATURE AND REPORT OF A CASE*KEVIN G. BARRY, WILLIAM H. CROSBYBlood volume in patients with Laennec's cirrhosis of the liver as determined by radioactive chromium-tagged red cellsSymptomatic and hemopathic hemolytic anemiaPostnecrotic cirrhosis of the liverIdiopathic Pulmonary HemosiderosisFamilial Mediterranean (Cooley's) anemia complicated by chronic hepatitisHÆMOGLOBINURIA IN TYPHOID FEVER TREATED WITH CHLORAMPHENICOLSymptomatic Haemolytic Anaemia Associated with Ovarian Teratoma in a ChildLaboratory Diagnosis of Polycythemia and AnemiaHÆMOLYTIC ANEMIA ASSOCIATED WITH HODGKIN'S DISEASESplenectomy for Acquired Hemolytic Jaundice in the AgedCongenital hemolytic icterusDie Erkrankungen des erythrocytären Systems 1 May 1939Volume 12, Issue 11Page: 1782-1796KeywordsCirrhosisHemolytic anemiaHemolytic jaundiceHospital medicineLiver diseasesLiver fibrosisMean corpuscular volumeResearch fundingResearch grantsReticulocytes ePublished: 1 December 2008 Issue Published: 1 May 1939 PDF downloadLoading ...