TUBERCULOMAS OF THE CENTRAL NERVOUS SYSTEM: REVIEW AND REPORT OF FOUR CASES SUCCESSFULLY MANAGED WITH SURGERY AND CHEMOTHERAPY
Authors: M SCHWARTZ, R A GILMAN, J S ROBEY, J SETTLE, L E PADDOCK
Journal: Annals of Internal Medicine (1955)

Article1 May 1955TUBERCULOMAS OF THE CENTRAL NERVOUS SYSTEM: REVIEW AND REPORT OF FOUR CASES SUCCESSFULLY MANAGED WITH SURGERY AND CHEMOTHERAPYMORTON SCHWARTZ, M.D., RICHARD A. GILMAN, M.D., JOHN S. ROBEY, M.D., JANET SETTLE, M.D., LELAND E. PADDOCK, M.D.MORTON SCHWARTZ, M.D., RICHARD A. GILMAN, M.D., JOHN S. ROBEY, M.D., JANET SETTLE, M.D., LELAND E. PADDOCK, M.D.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-42-5-1076 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptIn the past the prognosis of tuberculomas of the central nervous system has been considered grave, primarily because of the usual progression to tuberculous meningitis, either spontaneously or as the aftermath of attempted surgical intervention. As recently as 1932 Cushing advocated decompression as the only surgical procedure for these lesions.1Surgical results remained poor1, 2until the introduction of the antituberculous chemotherapeutic agents, streptomycin andp-aminosalicylic acid (PAS) to combat and prevent the complicating meningitis. With the addition of isoniazid to the therapeutic armamentarium, another potent agent is now available. Because of these advances, the previous pessimistic attitude toward surgical...Bibliography1. Cushing H: Intracranial tumors, 1932, Charles C Thomas, Springfield, Illinois. Google Scholar2. Van Wagenen WP: Tuberculoma of the brain, Arch. Neurol. and Psychiat. 17: 57, 1927. CrossrefGoogle Scholar3. WilsonRuppBartle GCH: Tuberculoma of the central nervous system, Tr. Am. Neurol. A. 67: 40, 1941. Google Scholar4. LewisonFreilichRagens MEO: Tuberculoma of the brain, Ann. Int. Med. 7: 1141, 1934. LinkGoogle Scholar5. ScottGraves EG: Tuberculoma of the brain, Am. Rev. Tuberc. 27: 171, 1933. Google Scholar6. Starr MA: Cyclopedia of diseases of children: intracranial tumors (1890), Philadelphia, Vol. 4, p. 551. Google Scholar7. Starr MA: Brain surgery, 1893, William Wood & Co., New York, p. 202. Google Scholar8. RichMcCurdock ARHA: The pathogenesis of tuberculous meningitis, Bull. Johns Hopkins Hosp. 52: 5, 1933. Google Scholar9. GarlandArmitage HGG: Intracranial tuberculoma, J. Path. and Bact. 37: 461, 1933. CrossrefGoogle Scholar10. Guiot G: Tuberculoma compressing the spinal cord, Rev. de la tuberc. 16: 725, 1952. MedlineGoogle Scholar11. ShenkinHornGrant HARCFC: Lesions of the spinal epidural space producing cord compression, Arch. Surg. 51: 125, 1945. CrossrefMedlineGoogle Scholar12. Mallory FB: The principles of pathologic histology, 1929, W. B. Saunders Co., Philadelphia. Google Scholar13. GrinkerLifvendahl RA: A study of cerebral tuberculoma, Arch. Neurol. and Psychiat. 20: 419, 1928. Google Scholar14. Anderson FN: Tuberculoma of the central nervous system, Arch. Neurol. and Psychiat. 20: 354, 1928. CrossrefGoogle Scholar15. Gonzalez-Revilla A: Intracranial tuberculomas, J. Neurosurg. 9: 555, 1952. CrossrefMedlineGoogle Scholar16. AsenjoValladaresFierro AHJ: Tuberculomas of the brain, Arch. Neurol. and Psychiat. 65: 146, 1951. CrossrefGoogle Scholar17. Orley A: Neuroradiology, 1949, Charles C Thomas, Springfield, Illinois. Google Scholar18. WeinbergerGrant LMFC: Calcified tuberculoma of the brain, Am. J. Roentgenol. 47: 525, 1942. Google Scholar19. BernsteinKruegerNayer TCEGHR: Tuberculoma of the brain, Am. Rev. Tuberc. 62: 654, 1950. MedlineGoogle Scholar20. Des AutelsPfeutze EJKH: Current treatment of tuberculous meningitis: a preliminary report, Ann. Int. Med. 40: 1135, 1954. LinkGoogle Scholar21. Torres-Gost J: Treatment of tuberculous meningitis with streptomycin and isoniazid, Lancet 2: 693, 1953. CrossrefGoogle Scholar22. DottLevin NME: Intracranial tuberculoma, Edinburgh M. J. 46: 36, 1939. MedlineGoogle Scholar23. BuchsteinAdson HFAW: Tuberculoma of the brain, Arch. Neurol. and Psychiat. 43: 635, 1940. CrossrefGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: *Received for publication September 29, 1954.The opinions expressed are those of the authors and do not necessarily reflect those of the United States Public Health Service or the Bureau of Indian Affairs.†Senior Assistant Surgeon, U. S. P. H. S. (R), Tacoma Indian Hospital, Tacoma, Washington. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byBrainstem Tuberculoma in PregnancyTuberculoma of the brain stem: control of relapses by steroid therapyDiagnostik der intrakraniellen GeschwülsteTUBERCULOMA OF THE BRAIN WITH TUBERCULOUS ADENITIS AND EPIDIDYMITIS*SHELDON R. COGAN, M.D., JOHANN S. BORNSTEIN, M.D. 1 May 1955Volume 42, Issue 5Page: 1076-1088KeywordsCentral nervous systemChemotherapeutic agentsChemotherapyIsoniazidMedical servicesMeningitisPeriodic acid SchiffStreptomycinSurgeonsSurgery Issue Published: 1 May 1955 PDF downloadLoading ...