SPRUE REFRACTORY TO VITAMIN B_12; SATISFACTORY RESPONSE TO FOLIC ACID
Authors: B S COHEN, L M MEYER, R FADEM
Journal: Annals of Internal Medicine (1952)

Case Reports1 June 1952SPRUE REFRACTORY TO VITAMIN B12; SATISFACTORY RESPONSE TO FOLIC ACIDB. STANLEY COHEN, M.D., LEO M. MEYER, M.D., ROBERT FADEM, M.D.B. STANLEY COHEN, M.D.Search for more papers by this author, LEO M. MEYER, M.D.Search for more papers by this author, ROBERT FADEM, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-36-6-1533 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptINTRODUCTIONThe hematologic and clinical response of patients with macrocytic anemia to the administration of pteroylglutamic acid has been well established. Although folic acid does not represent a complete treatment for pernicious anemia, it has been found most useful in nutritional macrocytic anemia, megaloblastic anemia of infancy, macrocytic anemia of pregnancy and sprue.1, 2 Thymine (5-methyl uracil) has been found efficacious in the treatment of certain of the macrocytic anemias in relapse, notably pernicious anemia and sprue, when administered in doses bearing a ratio of 5,000:1 to the required dosage of folic acid.3, 4More recently, the applications of vitamin...Bibliography1. SpiesVilterKochCaldwell TDCFMBMH: Observations of the antianemic properties of synthetic folic acid, South. M. J. 38: 707, 1945. CrossrefGoogle Scholar2. VilterSpiesKoch CFTDMB: Further studies on folic acid in the treatment of macrocytic anemia, South. M. J. 38: 781, 1945. CrossrefMedlineGoogle Scholar3. SpiesVilterClineFrommeyer TDCFJKWB: The substitution of thymine for folic acid in the treatment of macrocytic anemias in relapse, South. M. J. 39:269, 1946. CrossrefMedlineGoogle Scholar4. SpiesFrommeyerGarcia LopezLopez TocaGwinner TDWBGRG: Hemopoietic action of 5-methyl uracil (thymine) in tropical sprue, Lancet 1: 883, 1946. CrossrefMedlineGoogle Scholar5. West R: Activity of vitamin B12 in Addisonian pernicious anemia, Science 107: 398, 1948. CrossrefMedlineGoogle Scholar6. SpiesStoneAramburu TDRET: Observations on the antianemic properties of vitamin B12 , South. M. J. 41: 522, 1948. CrossrefMedlineGoogle Scholar7. SpiesGarcia LopezMilanesLopez TocaCulver TDGFRB: Observations on the hemopoietic response of persons with tropical sprue to vitamin B12 , South. M. J. 41: 523, 1948. CrossrefMedlineGoogle Scholar8. SpiesSuarez TDRM: Response of tropical sprue to vitamin B12 , Blood 3: 1213, 1948. CrossrefMedlineGoogle Scholar9. SpiesStoneGarcia LopezMilanesLopez TocaAramburu TDREGFRT: Vitamin B12 by mouth in pernicious and nutritional macrocytic anemia and sprue, Lancet 257: 454, 1949. CrossrefGoogle Scholar10. MeyerSawitskyCohenKrimFademRitz LMABSMRND: Oral treatment of pernicious anemia with vitamin B12 , Bull. New York Acad. Med. 26: 263, 1950. Google Scholar11. SpiesSuarezGarcia LopezMilanesStoneLopez TocaAramburuKartus TDRMGFRERTS: Tentative appraisal of vitamin B12 as a therapeutic agent, J. A. M. A. 139: 521, 1949. CrossrefMedlineGoogle Scholar12. DayHallPease LABEGL: Macrocytic anemia of pregnancy refractory to vitamin B12 therapy. Response to treatment with folic acid; report of a case, Proc. Staff Meet., Mayo Clin. 24: 149, 1949. MedlineGoogle Scholar13. BethellMeyersNeligh FHMCRB: Vitamin B12 in pernicious anemia and puerperal macrocytic anemia, J. Lab. and Clin. Med. 33: 1477, 1948. MedlineGoogle Scholar14. Bethell FH: Treatment of macrocytic anemias with vitamin B12 , J. Am. Dietet. A. 26:89, 1950. CrossrefMedlineGoogle Scholar15. SuarezSpies RMTD: The effectiveness of vitamin B12 in the treatment of tropical sprue, Bol. Asoc. méd. de Puerto Rico 40: 199, 1948. MedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: *Received for publication July 22, 1950.From the Medical Service, Bronx Veterans Hospital, Kingsbridge Road, Bronx, New York.Sponsored by the Veterans Administration and published with the approval of the Chief Medical Director. The statements and conclusions published by the authors are a result of their own study and do not necessarily reflect the opinion or policy of the Veterans Administration. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byMALABSORPTION SYNDROME: INTESTINAL ABSORPTION OF VITAMIN B12*†SANFORD OXENHORN, M.D., SOLOMON ESTREN, M.D., LOUIS R. WASSERMAN, M.D., F.A.C.P., DAVID ADLERSBERG, M.D., F.A.C.P. 1 June 1952Volume 36, Issue 6Page: 1533-1537KeywordsAnemiaFolic acidMedical servicesMegaloblastic anemiaNutritionPernicious anemiaPregnancy ePublished: 1 December 2008 Issue Published: 1 June 1952 PDF downloadLoading ...