tbuckley/cabot-search huggingface dataset:
Bioweapons Preparedness Chief Discusses Priorities in World of 21st-Century Biology
Authors: D A Henderson
Journal: JAMA (2002)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Abstract 17052: Significance of Micro-vessels Within Atherosclerotic Coronary Plaques: a Color-coded Intravascular Ultrasound Study
Authors: Toshihiko Nishida, Takafumi Hiro
Journal: Circulation (2014)

Background and Purpose: It has been documented that neovascularization in atherosclerotic plaques is associated with plaque vulnerability. This study was to examine tissue characteristics of plaque with micro-channels detected by optical coherence tomography (OCT). The tissue was assessed by use of a commercially available color-coded intravascular ultrasound (IVUS), iMap software. Method: A total of 61 coronary plaques was classified into two groups: plaques with micro-channels (Pm, n=37) and without (Po, n=24). Micro-channel was defined as a tiny tubule with a diameter of 50 to 300 micrometers detected over 3 or more frames in OCT. Plaques over a length of 5mm were also analyzed by IVUS at the corresponded portion of the OCT imaging. The i-Map software identified four types of tissue component such asfibrotic, lipidic, necrotic, and calcified areas. Result: There was no significant difference in plaque and vessel volume between the two groups. However, % content of fibrotic area was significantly smalle...
Leber Hereditary Optic Neuropathy
Authors: John B. Kerrison, Neil Howell, Neil R. Miller, Lawrence Hirst, W. Richard Green
Journal: Ophthalmology (1995)

Background: Leber hereditary optic neuropathy (LHON) is a mitochondrial genetic dis order characterized by bilateral central visual loss typically in early adulthood.Few histopath ologic studies, including ultrastructural and molecular genetic analysis, have been reported.Methods: Ocular tissue was obtained postmortem from an 81-year-old woman with LHON from the Queensland 1 pedigree characterized by mutations at nucleotide positions 4160 and 14484.Routine histopathologic studies, electron microscopy, elec tron-probe analysis, and molecular genetic analysis were performed.Results: Marked atrophy of the nerve fiber and retinal ganglion cell layers and optic nerves was present.Results of electron microscopic examination demonstrated 1 .2JLm electron-dense, double-membrane-bound inclusions, consisting of calcium by electron probe analysis, in retinal ganglion cells.The optic nerve was homoplasmic for mutations 4160 and 14484.Conclusion: Optic nerve and inner retinal atrophy in LHON may be a result of metabolic mitochondrial dysfunction leading to intramitochondrial calcification.Homo plasmy for mitochondrial mutations 4160 and 14484 in the leukocyte/platelet fraction of whole blood may correlate with homoplasmy in the optic nerve.Ophthalmology 1 995; 102
Effect of Sleep Deprivation on Response to Immunizaton
Authors: Janine Jagger, Vincenzo Puro, Gabriella De Carli
Journal: JAMA (2002)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Cancer Cells in Sheep's Clothing
Authors: Brian Vastag
Journal: JAMA (2001)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Outlines of Comparative Anatomy of Vertebrates.
Authors: J. S. Kingsley
Journal: JAMA (1926)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Abstract 3070: Capture, isolation, and mutational analysis of single pancreatic circulating tumor cells using NanoVelcro technology
Authors: Jacob S. Ankeny, Shuang Hou, Millicent Lin, Matthew Frias, Hank OuYang, Min Song, Matthew M. Rochefort, Mark D. Girgis, Hsian-Rong Tseng, James S. Tomlinson
Journal: Cancer Research (2014)

Abstract Introduction: Circulating tumor cells (CTCs) have been developed as a biomarker in several cancers, but not in pancreatic cancer (PDAC). The available clinical technology for CTC study, CellSearch, suffers from limited ability to perform molecular analysis. We sought to evaluate a novel microfluidic NanoVelcro technology coupled to laser micro-dissection (LMD), for CTC capture and single cell analysis of KRAS mutations to confirm tumor origin of captured CTCs. Methods: NanoVelcro utilizes a nano-spun polymer fiber, modified with streptavidin, to capture CTCs using biotinylated antibodies. The system was optimized with the CFPAC-1 (EpCAM+, KRAS G12 to V) cell line spiked into healthy donor blood. Patient samples were collected from 2 mL peripheral venous blood and run at the optimized flow rate of 1mL/hr. CTCs were defined by size (≥ 10 µm) and immuno-staining pattern (DAPI+/CK+/CD45-). Using LMD, single cells were isolated and subjected to whole genome amplification followed by PCR of KRAS exon 1 and subsequent Sanger Sequencing. Results: The NanoVelcro system allowed for detection of mutant KRAS in isolated CFPAC-1 cells. 6 CTCs were then isolated from a known KRAS G12 to V mutant patient and 3/6 (50.0%) captured CTCs were found to have KRAS G12 to V mutations while normal WBCs from the same patient contained wild-type KRAS. Conclusions: The microfluidic NanoVelcro technology demonstrated capture of pancreatic CTCs and may prove useful in the development of CTCs as a biomarker in PDAC. Application of LMD enabled single cell KRAS mutational analysis confirming cancer origin of isolated CTCs and supporting our current PDAC CTC identification criteria based on immuno-staining. This promising technology, combined with LMD, opens the door for molecular characterization of CTCs, thus providing insight into the biology of metastasis while potentially revealing molecular targets for therapeutics. Citation Format: Jacob S. Ankeny, Shuang Hou, Millicent Lin, Matthew Frias, Hank OuYang, Min Song, Matthew M. Rochefort, Mark D. Girgis, Hsian-Rong Tseng, James S. Tomlinson. Capture, isolation, and mutational analysis of single pancreatic circulating tumor cells using NanoVelcro technology. [abstract]. In: Proceedings of the 105th Annual Meeting of the American Association for Cancer Research; 2014 Apr 5-9; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2014;74(19 Suppl):Abstract nr 3070. doi:10.1158/1538-7445.AM2014-3070
Estrogen Administration to Aged Female Monkeys with No Resultant Tumors
Authors: Earl T. Engle, Cecil Krakower, C. D. Haagensen
Journal: Cancer Research (1943)

5 old female rhesus monkeys were treated with implantation of crystals or pellets of alpha-estradiol for more than 2 years in order to determine if estrogen administration would be tumor producing.  Pellets were implanted into the mammary glands and the thigh every 5-6 weeks.  The total amount of administered estrogen was 575-825 mg/monkey.  Complete autopsies were performed on 3 monkeys with special detail to the ovaries mammary glands uterus cervix and vagina.  Cystic changes developed in the mammary glands of 2 out of 4 monkeys.  The ducts were dilated to many times their normal diameter.  The lining epithelium was normal without papillary or other proliferation.  The acine of the glands were normal.  Pronounced cystic and glandular hyperplasia of the endometrium was present in 2 animals.  Squamous cell metaplasia was present in all animals extending throughout the endocervix and into the racimose glands.  The organs were all without neoplastic changes.
The intrinsic factor–vitamin B12 receptor, cubilin, is a high-affinity apolipoprotein A-I receptor facilitating endocytosis of high-density lipoprotein
Authors: Renata Kozyraki, John Fyfe, Mette Kristiansen, Christian Gerdes, Christian Jacobsen, Shiying Cui, Erik Ilsø Christensen, Maria Aminoff, Albert de la Chapelle, Ralf Krahe, Pierre J. Verroust, Søren K. Moestrup
Journal: Nature Medicine (1999)
Studies on human epidermal Langerhans cells.
Authors: LASSE R. BRAATHEN
Journal: British Journal of Dermatology (1980)

Human epidermis from nickel sensitive patients was separated from dermis by means of a suction blister device and dissociated with trypsin. The epidermal cell suspensions obtained contained 3–5% Langerhans cells as judged by immunofluorescence staining of the cells with a rabbit anti‐DR anti‐serum. The epidermal cells were co‐cultured with purified autologous T lymphocytes with or without nickel sulphate. A strong proliferative T lymphocyte response to nickel sulphate was obtained provided epidermal cells were also present. Pretreatment of the epidermal cells with anti‐DR antiserum abolished or greatly reduced the response. These data indicate that epidermal cells are able to present nickel sulphate to T lymphocytes in an immunogenic way. Since the responsible cells were DR antigen positive, it is highly probable that the cells responsible for these functions are the Langerhans cells.
Effects of Age, Gender, Obesity, and Diabetes on the Efficacy and Safety of the Selective A2A Agonist Regadenoson Versus Adenosine in Myocardial Perfusion Imaging
Authors: Manuel D. Cerqueira, Patricia Nguyen, Peter Staehr, S. Richard Underwood, Ami E. Iskandrian
Journal: JACC. Cardiovascular imaging (2008)
Lithium augmentation of combined neuroleptic-tricyclic treatment in delusional depression
Authors: L H Price, Y Conwell, J C Nelson
Journal: American Journal of Psychiatry (1983)

Recent clinical studies have reported rapid improvement following administration of lithium to depressed patients who are unresponsive to tricyclic antidepressants. The clinical value of lithium augmentation would be greatest in subtypes of depression refractory to tricyclic treatment, such as delusional depression. The authors describe the results of a preliminary study of lithium augmentation in six patients with delusional depression who were unresponsive to combined neuroleptic-tricyclic treatment. Of the six, three had a dramatic response, two had a more gradual response, and one was unresponsive. The authors discuss alternative mechanisms of lithium action in these patients.
660. Efficient Production of Transgenic Pigs by Lentiviral Gene Transfer into Preimplantation Embryos
Authors: Andreas Hofmann, Barbara Kessler, Sonja Ewerling, Marc Boelhauve, Gottfried Brem, Eckhard Wolf, Alexander Pfeifer
Journal: Molecular Therapy (2004)

Transgenic pigs are of medical relevance, because they could provide an unlimited source of genetically modified organs for xenotransplantation. In addition, disease models using transgenic pigs would be much more clinically relevant than rodent models, owing to the high similarities of human and porcine anatomy and physiology. Presently, DNA- microinjection (DNA-MI) is the most widespread method for generating transgenic pigs. However, transgenesis rates are extremely low and only 1% of the embryos injected give rise to transgenic animals.
The impact of anxiety and depression on outcomes of pulmonary rehabilitation in COPD
Authors: Andreas von Leupoldt, Karin Taube, Kirsten Lehmann, Anja Fritzsche, Helgo Magnussen
Journal: European Respiratory Journal (2011)

Anxiety and depression are highly prevalent comorbidities in chronic obstructive pulmonary disease (COPD) and related to a negative course of disease. We examined the impact of anxiety and depression on functional performance, dyspnea and quality of life in patients with COPD at start and end of an intensive 3-week outpatient pulmonary rehabilitation program (PR).  Before and after PR, 238 patients with COPD (mean age = 62 years) underwent a 6-minute walking test (6MWT). In addition, anxiety, depression, quality of life and dyspnea at rest, after 6MWT and during activities were measured before and after PR.  Except for dyspnea at rest, improvements were found for all outcome measures after PR. Multiple regression analyses showed that before and after PR, anxiety and depression were associated with greater dyspnea after 6MWT and during activities and with reduced quality of life, even after controlling for effects of age, sex, lung function and smoking status. Furthermore, before and after PR anxiety was related to greater dyspnea at rest, whereas depression was associated with reduced functional performance in the 6MWT.  The results demonstrate that anxiety and depression are significantly associated with increased dyspnea and reduced functional performance and quality of life in patients with COPD. These negative associations remain stable over the course of PR, even when improvements in most of these outcomes are achieved during PR. The findings underline the clinical importance of diagnosing and treating anxiety and depression in patients with COPD.
Targeting the translational apparatus to improve leukemia therapy: roles of the PI3K/PTEN/Akt/mTOR pathway
Authors: A M Martelli, C Evangelisti, W Chappell, S L Abrams, J Bäsecke, F Stivala, M Donia, P Fagone, F Nicoletti, M Libra, V Ruvolo, P Ruvolo, C R Kempf, L S Steelman, J A McCubrey
Journal: Leukemia (2011)
The Chemistry of Urea. The Theory of Its Constitution, and of the Origin and Mode of Its Formation in Living Organisms.
Authors: Emil A. Werner
Journal: JAMA (1924)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The relationship between maternal folate status in pregnancy, cord blood folate levels, and allergic outcomes in early childhood
Authors: J. A. Dunstan, C. West, S. McCarthy, J. Metcalfe, S. Meldrum, W. H. Oddy, M. K. Tulic, N. D’Vaz, S. L. Prescott
Journal: Allergy (2011)

To cite this article: Dunstan JA, West C, McCarthy S, Metcalfe J, Meldrum S, Oddy WH, Tulic MK, D’Vaz N, Prescott SL. The relationship between maternal folate status in pregnancy, cord blood folate levels, and allergic outcomes in early childhood. Allergy 2012; 67 : 50–57. Abstract Background: Dietary changes may epigenetically modify fetal gene expression during critical periods of development to potentially influence disease susceptibility. This study examined whether maternal and/or fetal folate status in pregnancy is associated with infant allergic outcomes. Methods: Pregnant women ( n = 628) were recruited in the last trimester of pregnancy. Folate status determined by both food frequency questionnaires and folate levels in maternal and cord blood serum was examined in relation to infant allergic outcomes at 1 year of age ( n = 484). Results: Infants who developed allergic disease (namely eczema) did not show any differences in cord blood or maternal folate levels compared with children without disease. Although maternal folate intake from foods was also not different, folate derived from supplements was higher ( P = 0.017) in children with subsequent eczema. Furthermore, infants exposed to &gt;500 μg folic acid/day as a supplement in utero were more likely to develop eczema than those taking &lt;200 μg/day (OR [odds ratio] = 1.85; 95% CI 1.14–3.02; P = 0.013), remaining significant after adjustment for maternal allergy and other confounders. There was a nonlinear relationship between cord blood folate and sensitization, with folate levels &lt;50 nmol/l (OR = 3.02; 95% CI 1.16–7.87; P = 0.024) and &gt;75 nmol/l (OR = 3.59; 95% CI 1.40–9.20; P = 0.008) associated with greater sensitization risk than levels between 50 and 75 nmol/l. Conclusion: Fetal levels between 50 and 75 nmol/l appeared optimal for minimizing sensitization. While folate taken as a supplement in higher doses during the third trimester was associated with eczema, there was no effect on other allergic outcomes including sensitization. Further studies are needed to determine the significance of this.
High-Dose Statins in Acute Coronary Syndromes
Authors: Yale B Mitchel
Journal: JAMA (2005)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Abstract 14063: Frequency of Coronary Artery Fistulae and Extracardiac Neovascularization After Orthotopic Heart Transplantation
Authors: Babak Azarbal, Janet Wei, Sarabjeet Singh, Jesse Currier, Jignesh Patel, Antoine Hage, Raj Makkar, Jon Kobashigawa
Journal: Circulation (2011)

Introduction: Coronary artery fistula (CAF) is a rare coronary anomaly occurring in 0.2-0.3% of patients (pts). Orthotopic heart transplantation (OHT) may be associated with a higher frequency of CAF formation. The purpose of this study was to examine the frequency of CAF in a large cohort of OHT pts. Methods: We evaluated 368 consecutive coronary angiograms of OHT recipients transplanted between 1994-2010. Presence, type, size, and time to development of CAF were determined. Results: A total of 155 CAF (coronary cameral or coronary arteriovenous connections) or extracardiac neovascularization (anomalous connection without obvious drainage into a venous structure) were identified in 116 pts (31.5% of total) (Table 1). CAF to the right ventricle (possibly iatrogenic due to endomyocardial biopsy) were present in 9 pts (7.8%). Transplant age, donor age, and ischemic time were not significantly different between the pts with fistulae and those without. 96% of CAF were present by year 1 post OHT. No further in...
Transforming properties of chimeric TEL-JAK proteins in Ba/F3 cells
Authors: Virginie Lacronique, Anthony Boureux, Richard Monni, Stephanie Dumon, Martine Mauchauffé, Patrick Mayeux, Fabrice Gouilleux, Roland Berger, Sylvie Gisselbrecht, Jacques Ghysdael, Olivier A. Bernard
Journal: Blood (2000)