tbuckley/cabot-search huggingface dataset:
Expression of Normal Dystrophin Following Myoblast Transplantation to Duchenne Muscular Dystrophy Patients
Authors: Jacques P. Tremblay, Daniel Skuk, Bouchard Jean-Pierre, Michel Sylvain, Roy Raynald, Goulet Marilyne, Roy Brigitte, Pierre Chapdelaine, Dugré Francine, Jean-Guy Lachance, Louise Deschènes, Hélène Senay
Journal: Molecular Therapy (2004)

Top of pageAbstract
Three Duchenne muscular dystrophy (DMD) patients received injections of myogenic cells obtained from skeletal muscle biopsies of normal donors. Cells were injected in 1 cm3 of the Tibialis anterior by 25 parallel injections. We performed similar patterns of saline injections in the contralateral muscles as controls. The patients received tacrolimus for immunosuppression. Muscle biopsies were performed at the injected sites 4 weeks later. We observed dystrophin-positive myofibers in the cell-grafted sites: 9 % (patient 1), 6.8 % (patient 2) and 11 % (patient 3). Since patients 1 and 2 had identified dystrophin-gene deletions these results were obtained using mAbs specifically to epitopes coded by the deleted exons. Donor-dystrophin was absent in the control sites. Patient 3 had exon duplication and thus specific donor-dystrophin detection was not possible. However there was 4-fold more dystrophin-positive myofibers in the cell-grafted than in the control site. Donor-dystrophin transcripts were detected by RT-PCR (using primers reacting with a sequence in the deleted exons) only in the cell-grafted sites in patients 1 and 2. Dystrophin transcripts were more abundant in the cell-grafted than in the control site in patient 3. Therefore, significant dystrophin expression can be obtained in the skeletal muscles of DMD patients following specific conditions of cell delivery and immunosuppression.

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Abstract 5517: PTC596-induced Bmi1 hyper-phosphorylation via Cdk1/2 activation resulting in tumor stem cell depletion
Authors: Min Jung Kim, Liangxian Cao, Josephine Sheedy, Nicole Risher, Melissa Dumble, Chang-Sun Lee, Nadiya Sydorenko, Ramil Baiazitov, Wu Du, Young-Choon Moon, Marla L. Weetall, Joseph Colacino, Thomas W. Davis
Journal: Cancer Research (2014)

Abstract The Polycomb group (PcG) transcription repressor BMI1 is highly expressed in human cancers and is required for the clonogenic self-renewal and tumorigenesis of human cancer cells including those in hematological cancer and neuroblastoma. PTC596 is efficacious in vivo across a range of xenograft tumor models, including models of glioblastoma, fibrosarcoma and leukemia as well as orthotopic models of GBM. With EC50 values of 30-200 nM in a variety of tumor cell lines, PTC596 selectively reduces the level of functional BMI1 protein resulting in the depletion of the tumor stem cell fraction. PTC596 induces the hyper-phosphorylation of BMI1 leading to its degradation and the reduction of polycomb repressive complex 1 (PRC1) activity. Mechanistic studies suggest that PTC596 inhibits APC/CCDC20 activity resulting in the persistent activation of CDK1 and CDK2 which mediate the hyperphosphorylation of BMI1. Studies are ongoing to elucidate the mechanism of PTC596 inhibition of APC/CCDC20 and its preferential depletion of the tumor stem cell fraction. Citation Format: Min Jung Kim, Liangxian Cao, Josephine Sheedy, Nicole Risher, Melissa Dumble, Chang-Sun Lee, Nadiya Sydorenko, Ramil Baiazitov, Wu Du, Young-Choon Moon, Marla L. Weetall, Joseph Colacino, Thomas W. Davis. PTC596-induced Bmi1 hyper-phosphorylation via Cdk1/2 activation resulting in tumor stem cell depletion. [abstract]. In: Proceedings of the 105th Annual Meeting of the American Association for Cancer Research; 2014 Apr 5-9; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2014;74(19 Suppl):Abstract nr 5517. doi:10.1158/1538-7445.AM2014-5517
Prognostic value of fluorine-18 fluorodeoxyglucose (18-FDG) positron emission tomography imaging in patients with non-small cell lung carcinoma
Authors: Ahmet Selim Yurdakul, Fatma Yildirim, Sevket Özkaya, Ümit Özgür Akdemir, Can Öztürk
Journal: European Respiratory Journal (2012)

To determine whether the amount of 18-FDG maximum standardized uptake (SUVmax) value on the PET/CT imaging at the time of presentation has prognostic significance in patients with non–small-cell lung cancer (NSCLC).   Patients and Methods   A retrospective review identified 142 patients with NSCLC who underwent 18-FDG PET/CT study at the time of diagnosis. Extensive clinical data, including tumor histologic cell type, stage at presentation, treatment, and SUVmax values in the primary tumor were recorded and survival was examined.   Results   Total 142 patients were included the study. 32 patients of them have stage I and II. The median SUVmax of early stage patients is determined 13.5. Early stage patient population was subdivided into two groups according to the median value for survival. The median survival of the 17 patients with the primary tumor having an SUVmax ≤ 13.0 was 32.5 months whereas the median survival of the 15 patients with the primary tumor having an SUVmax > 13.0 was 19.0 months. There was no stastistical differences between two groups (p=0.463). The 110 patients were on advanced stage (stage III and 4). Using the median SUVmax of 12.5, the patient population was subdivided in two groups. The median survival of the 54 patients with the primary tumor having an SUVmax ≤ 12.5 was 12.0 months whereas the median survival of the 56 patients with the primary tumor having an SUVmax > 12.5 was 11.0 months. There was no stastistical differences between two groups (p=0.236).   Conclusion   18-FDG SUVmax uptake of the primary lesions in patients with a new diagnosis of NSCLC does not have a significant relationship with survival.
Swan Attacked by a Dog
Authors: M. Therese Southgate
Journal: JAMA (2003)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Elevated serum thymidine kinase levels identify a subgroup at high risk of disease progression in early, nonsmoldering chronic lymphocytic leukemia.
Authors: Michael Hallek, Irmgard Langenmayer, Christoph Nerl, Wolfgang Knauf, Hermann Dietzfelbinger, Dagmar Adorf, Marianne Ostwald, Raymonde Busch, Ingrid Kuhn-Hallek, Eckhard Thiel, Bertold Emmerich
Journal: Blood (1999)
“Distortion” of passive smoking evidence provokes controversy in Israel
Authors: Judy Siegel-Itzkovich
Journal: BMJ (2000)

Israel's respected daily newspaper in the Hebrew language, which markets itself as “the newspaper for thinking people,” has published a six page cover story in its magazine supplement dismissing the fact that passive smoking is dangerous to health and praising some of the so-called benefits of active smoking. The article in Ha'aretz, which was largely based on a misrepresentation and misinterpretation of an epidemiological meta-analysis by Copas and Shi in the BMJ (2000;320:417-8), has been roundly denounced by Israeli public health experts and by Israel's health minister, Shlomo Benizri.

As a result of the article, the health minister called on all Israeli print media, “especially Ha'aretz,” to stop accepting and publishing cigarette advertisements. Currently, the only Israeli publications to adopt such a policy on tobacco are Bamahaneh (the magazine of the Israel Defence Forces) and Yom LeYom (the weekly paper of the ultra-Orthodox Shas party).

Minister Benizri, a rabbi from the Shas party who—unlike many of his predecessors—adopted a policy aimed at reducing smoking, said that research had found a connection between the amount of tobacco advertising in each paper and the manner and …
Abstract 13054: Thymosin Beta-4-Treated Endothelial Progenitor Cells Improve Cardiac Function and Vasculogenesis in Diabetic Obese Rats with Myocardial Infarction
Authors: Poay Sian S Lee, Lei Ye, Yei-Tsung Chen, Eric Yin Hao Khoo, Tiong Cheng Yeo, Huay Cheem Tan, Arthur Mark Richards, Kian Keong Poh
Journal: Circulation (2014)

Introduction: Diabetes and obesity are associated with endothelial dysfunction and may impair circulating endothelial progenitor cells (EPCs). Thymosin beta-4 (Tβ4), a novel peptide with angiogenic properties, may improve EPC number and function. Hypothesis: We aim to transplant allogenic Tβ4-treated EPCs in Zucker Diabetic Fatty (ZDF) rats with myocardial infarction (MI) and hypothesize that Tβ4-treated EPCs may improve cardiac function, vasculogenesis and upregulate angiogenic cytokines and genes, compared to non-treated EPCs and controls. Methods: The left anterior descending coronary artery was permanently ligated to induce experimental MI on ZDF rats (n=19), divided into MI+saline(n=6); MI+EPCs (n=6) and MI+Tβ4-treated EPCs (n=7). Peripheral blood mononuclear cells were harvested from ZDF rats and isolated using Ficoll density gradient centrifugation and grown on fibronectin-coated plates. EPCs were treated with Tβ4 (1μg/mL) on day 7. At day 10, allogenic EPCs were harvested and transplanted into the peri-infarcted myocardium. Echocardiographic examination including strain assessment, immunohistological assessments and assays of angiogenic cytokines were performed 6 weeks after surgery. Results: Left ventricular (LV) ejection fraction was improved in Tβ4-treated EPCs (72.0±7.6%) and non-treated EPCs rats (80.5±5.9%) compared to control MI rats (64.8±19.7%) (P=0.04). Similar improvement was observed in LV radial strain rate in rats with Tβ4-treated EPCs (-7.22±1.24 1/s) and non-treated EPCs (-6.67±2.66 1/s) compared to MI only (-4.08±3.75 1/s) (P&lt;0.01). Vascular density (CD31) and c-kit density (CD117) were significantly upregulated in Tβ4-treated EPCs rats compared to MI (P=0.03; P=0.005 respectively) and non-treated EPCs rats (P=0.04; P=0.04 respectively). Angiogenic cytokines of PDGF-BB, IGF-1 and VEGF levels were increased by 1.5 fold in Tβ4-treated EPCs and supported by similar trend in mRNA levels compared to non-treated EPCs (P&lt;0.01). Conclusions: ZDF rats with Tβ4-treated EPCs had significant improvement in cardiac function, increased vasculogenesis and upregulation of angiogenic cytokines and genes. This suggests that Tβ4 may be beneficial in enhancing efficacy of EPCs in cell-based therapies.
Equestrienne (At the Circus Fernando)
Authors: M. Therese Southgate
Journal: JAMA (2001)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Abstract 4382: Relative expression of miR200 microRNAs and ERBB family negative regulator Mig6 in estimation of EMT status and erlotinib sensitivity
Authors: Eugene G. Izumchenko, Xiaofei Chang, Christina Michailidi, Luciane Kagohara, Rajani Ravi, Mariana Brait, Atul Bedi, David Sidransky
Journal: Cancer Research (2014)

Abstract While sensitizing mutations in the tyrosine kinase domain of epidermal growth factor receptor (EGFR) render tumors more sensitive to EGFR tyrosine kinase inhibitors (TKIs), these genetic alterations are present in only a minority of patients who respond to treatment and are rare in tumors other than NSCLCs. Thus, clinical benefit of TKIs in a subset of patients with wild-type EGFR may be underestimated due to the lack of appropriate predictive markers to stratify them from larger number of patients who do not response. It has long been observed that the response of anti-EGFR agents is associated with epithelial and mesenchymal transition (EMT) in multiple types of tumors without known EGFR mutations. However, little is known about the molecular mechanisms underlying this association, and no EMT-associated biomarkers of clinical utility have been successfully developed. Here we show that during the TGFβ-induced EMT, upregulation of mitogen-inducible gene 6 (Mig6), a negative regulator of EGFR, by microRNAs 200 (miR200) family is leading to reduced EGFR dependence, initiation of kinase switch in mesenchymal cells and subsequent insensitivity of these cells to EGFR inhibition. Moreover, we found that the ratio between mRNA levels of Mig6 and miR200c highly correlated with erlotinib sensitivity and EMT status in panel of 25 cancer cell lines of different tissue origins. Furthermore, analysis of directly xenografted human lung and pancreatic tumors (tumorgrafts) bearing wtEGFR demonstrated a higher response to EGFR inhibitor erlotinib for models with low Mig6 (mRNA)/miR200 ratio. Collectively, our data demonstrates that during the EMT-associated evolution of resistance to EGFR inhibitors, Mig6 expression is highly correlated with EMT status and identifies the ratio of Mig6 mRNA to miR200 as a novel, reliable and cost-effective predictor of biologic and clinical response to TKIs. Citation Format: Eugene G. Izumchenko, Xiaofei Chang, Christina Michailidi, Luciane Kagohara, Rajani Ravi, Mariana Brait, Atul Bedi, David Sidransky. Relative expression of miR200 microRNAs and ERBB family negative regulator Mig6 in estimation of EMT status and erlotinib sensitivity. [abstract]. In: Proceedings of the 105th Annual Meeting of the American Association for Cancer Research; 2014 Apr 5-9; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2014;74(19 Suppl):Abstract nr 4382. doi:10.1158/1538-7445.AM2014-4382
Abstract 53: Biomarkers of Cardiovascular Stress and Left Ventricular Hypertrophic Patterns: Cross-sectional relations and prognostic significance
Authors: Vanessa Xanthakis, Meredith Stevenson, Ramachandran S Vasan
Journal: Circulation (2014)

Background: Cardiac stress biomarkers (growth differentiation factor 15 [GDF-15], soluble ST-2 [ST2], high-sensitivity troponin I [hsTnI]) and B-type natriuretic peptide [BNP]) are associated with incident heart failure (HF) and left ventricular mass (LVM). It is unclear if biomarker levels and their prognostic significance vary according to LV hypertrophy (LVH) pattern and extent. We hypothesized that concentric &amp; eccentric LVH would be associated with highest biomarker levels; presence of both LVH and higher biomarker levels would indicate high HF risk. Methods and Results: We evaluated 2,425 Framingham Study participants free of HF (57% women, mean age 58 years) attending a routine examination, with available biomarker and echocardiographic measurements. We defined 4 LVH patterns: a. normal (normal LVM and Relative Wall Thickness [RWT]); b. concentric remodeling (normal LVM, elevated RWT); c. eccentric hypertrophy (elevated LVM, normal RWT); and d. concentric hypertrophy (elevated LVM and RWT). Adjusting for age &amp; sex, biomarker levels (except BNP) increased sequentially across LVH patterns a-d ( Figure ). BNP levels were lowest in concentric remodeling and highest in eccentric LVH. In multivariable models, all biomarkers were associated with incident HF (106 cases, 12 yrs follow-up). We observed a significant interaction only between BNP and LVM (p=0.02). In stratified analyses, higher LVM was associated with incident HF in both BNP strata (Hazard Ratios [HR] per SD increase in LVM = 2.24 [&lt;median BNP] and 1.35 [≥median BNP]; p&lt;0.01 for both). However, higher BNP was associated with incident HF only in the stratum with LVM&lt;median (HR = 2.09 per unit-increase in logBNP, p=0.003). Conclusions: In our large community-based sample, cardiac stress biomarker levels varied by LVH pattern. Contrary to our hypothesis, BNP levels were more strongly associated with HF in individuals with lesser degree of LVH.
Caspases Mediate Tumor Necrosis Factor-–Induced Neutrophil Apoptosis and Downregulation of Reactive Oxygen Production
Authors: Kouhei Yamashita, Atsushi Takahashi, Susumu Kobayashi, Hirokazu Hirata, Peter W. Mesner, Scott H. Kaufmann, Shin Yonehara, Kokichi Yamamoto, Takashi Uchiyama, Masataka Sasada
Journal: Blood (1999)
Quantitative Exfoliative Cytology of Normal and Abnormal Oral Mucosal Squames: Preliminary Communication
Authors: J G Cowpe
Journal: Journal of the Royal Society of Medicine (1984)

Quantitative techniques have been applied to the exfoliative cytology of normal and abnormal human oral mucosal squames. This study is ongoing but early results indicate that a normal baseline for clinically normal oral squames, related to age and site, may be difficult to achieve. However, results obtained for the pathological smears suggest that these techniques may improve the diagnostic sensitivity of cytology in the management of oral cancer.
Abstract P206: Ambulatory Blood Pressure Monitoring Phenotypes Among Individuals With and Without Diabetes: The Jackson Heart Study
Authors: Samantha G Bromfield, Daichi Shimbo, Alain Bertoni, Mario Sims, April P Carson, Paul Muntner
Journal: Circulation (2015)

Several ambulatory blood pressure monitoring (ABPM) phenotypes including masked hypertension are associated with an increased risk for cardiovascular disease (CVD). Diabetes is associated with CVD risk as well as a higher prevalence of hypertension. However, little is known about whether ABPM phenotypes differ between individuals with versus without diabetes. We evaluated the association between diabetes and ABPM phenotypes including clinic hypertension, awake hypertension, sustained hypertension, nocturnal hypertension, non-dipping pattern, white coat hypertension, and masked hypertension in the Jackson Heart Study (JHS). Baseline data collection included two clinic blood pressure measurements using standardized protocols. ABPM measurements were taken in the 24 hours following the baseline visit. Diabetes was defined as fasting glucose ≥126 mg/dL, hemoglobin A1c ≥6.5%, or use of diabetes medications. Of the 1,032 JHS participants with valid ABPM data (67.7% female, mean age 59.2 years), 253 (24.5%) had diabetes. The prevalence of clinic hypertension was similar for participants with and without diabetes (Table 1). After multivariable adjustment, diabetes was associated with an increased prevalence ratio of awake, sustained, and masked hypertension and a lower prevalence ratio of white coat hypertension compared with individuals without diabetes. In summary, there was an increased prevalence of adverse blood pressure phenotypes among individuals with versus those without diabetes that was not captured in the clinic setting alone. The role of ABPM for identifying high risk individuals with diabetes should be further investigated.
A BRIEF REVIEW OF ARTHRITIS AND ALLIED CONDITIONS IN TROPICAL DISEASES
Authors: J MORGAN, B I COMROE
Journal: Annals of Internal Medicine (1946)

Article1 February 1946A BRIEF REVIEW OF ARTHRITIS AND ALLIED CONDITIONS IN TROPICAL DISEASESJULIA MORGAN, M.D., BERNARD I. COMROE, M.D., F.A.C.P.JULIA MORGAN, M.D.Search for more papers by this author, BERNARD I. COMROE, M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-24-2-233 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptMen are being returned to the United States in increasing numbers from regions where they have been exposed to tropical diseases, hitherto largely unfamiliar to most physicians in this quarter of the world. Many of these diseases have already made their appearance in this country. Some, though not primarily classed as arthritides, present joint phenomena as part of their symptomatology. Many others have painful manifestations in various parts of the body, including the limbs. A description of such phenomena as they occur in tropical diseases may be of aid in diagnosis and in their differentiation from the better known diseases...Bibliography1. BLOCHBALDOCK OH: A case of rat-bite fever with demonstration of Spirillum minus , Jr. Pediat., 1937, x, 358. CrossrefGoogle Scholar2. KEYLARGE JAAM: Histoplasmosis of knee, Jr. Bone and Joint Surg., 1942, xxiv, 281. Google Scholar3. ROSENBERGDOCKERTYMEYERDING EFMBHW: Coccidioidal arthritis; report of case in which ankles were involved and condition was unaffected by sulfanilamide and roentgen therapy, Arch. Int. Med., 1942, lxix, 238. CrossrefGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Philadelphia, Pennsylvania*Received for publication July 27, 1945.From the Medical Clinic of the Hospital of the University of Pennsylvania.†Deceased. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byThe subcutaneous nodule: Its significance in the diagnosis of rheumatic diseaseGutartige Primärtumoren der Bronchien und LungenMENTAL EFFECTS' OF RESERPINETHE CURRICULUMSystemic BlastomycosisRHEUMATISM AND ARTHRITIS REVIEW OF AMERICAN AND ENGLISH LITERATURE OF RECENT YEARS (TENTH RHEUMATISM REVIEW)* Part IIWILLIAM D. ROBINSON, M.D., F.A.C.P., EDWARD W. BOLAND, M.D., F.A.C.P., JOSEPH J. BUNIM, M.D., F.A.C.P., DARRELL C. CRAIN, M.D., F.A.C.P., EPHRAIM P. ENGLEMAN, M.D., F.A.C.P., WALLACE GRAHAM, M.D., F.R.C.P. (C), L. MAXWELL LOCKIE, M.D., F.A.C.P., MAX M. MONTGOMERY, M.D., F.A.C.P., CHARLES RAGAN, M.D., F.A.C.P., MARIAN W. ROPES, M.D., F.A.C.P., EDWARD F. ROSENBERG, M.D., F.A.C.P., CHARLEY J. SMYTH, M.D. 1 February 1946Volume 24, Issue 2Page: 233-240KeywordsArthritisHospitalsTropical diseases ePublished: 1 December 2008 Issue Published: 1 February 1946 PDF downloadLoading ...