tbuckley/cabot-search huggingface dataset:
Abstract 284: Epigenome-wide study of sister study samples replicates and extends cpg sites associated with cigarette smoking
Authors: Sara Sophia Harlid, Zongli Xu, Vijayalakshmi Panduri, Dale P. Sandler, Jack A. Taylor
Journal: Cancer Research (2014)

Abstract Smoking increases the risk of many diseases -including cancer, and is also linked to blood DNA methylation changes that may be important in disease etiology. The objective of the current study was to identify and confirm potentially novel CpG sites associated with cigarette smoking. To do this we used two epigenome-wide datasets from the Sister Study. One included 908 women with methylation measurements at 27,578 CpG sites using the Illumina HumanMethylation27 BeadChip; the other included 200 women with methylation measurements for 473,844 CpG sites using the Illumina HumanMethylation450 BeadChip. Significant CpGs from the second dataset that were not included in the 27k assay were validated by pyrosequencing in a subset of 476 samples from the first dataset. We were able to successfully confirm smoking associations for nine previously established CpGs and identify two potentially novel CpGs: cg26764244 in GNG12 (p= 9.0×10-10) and cg22335340 in PTPN6 (p=2.9×10-05).In addition to this we provide the first independent confirmation of the association between smoking status and cg02657160 in CPOX (p=7.28x10-7). All 12 CpGs were under-methylated in current smokers and showed increasing percent methylation in former and never smokers. The CPOX CpG proved to be of particular interest as the corresponding enzyme is involved in heme biosynthesis and smoking is known to increase heme production. Our study extends the evidence base for smoking-related changes in DNA methylation. Citation Format: Sara Sophia Harlid, Zongli Xu, Vijayalakshmi Panduri, Dale P. Sandler, Jack A. Taylor. Epigenome-wide study of sister study samples replicates and extends cpg sites associated with cigarette smoking. [abstract]. In: Proceedings of the 105th Annual Meeting of the American Association for Cancer Research; 2014 Apr 5-9; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2014;74(19 Suppl):Abstract nr 284. doi:10.1158/1538-7445.AM2014-284
Abstract 13865: Relation Between Endothelial Function and Exercise-induced Myocardial Ischemia in Type 2 Diabetic Patients
Authors: Luca Branca, Giulio Russo, Angelo Villano, Monica Wu, Francesco Spera, Luigi Tanese, Alessandro Rizzi, Dario Pitocco, Antonino Di Franco, Gaetano A Lanza, Filippo Crea
Journal: Circulation (2014)

Purpose: A significant number of asymptomatic patients with type 2 diabetes mellitus (T2DM) develops significant ST-segment depression (STD) (>1 mm) during exercise stress test (EST), suggesting myocardial ischemia (MI) related to either macrovascular or microvascular coronary artery disease. Aim of this study was to assess whether there is any relation between endothelial dysfunction and EST-induced myocardial ischemia in this kind of patients. Methods: We studied 100 non insulin-dependent T2DM patients (age 62.7±8.8 years, 68 M) without any symptom or evidence of cardiovascular disease. All patients underwent a symptom/sign limited EST and assessment of the endothelium-dependent function through measurement of flow-mediated dilation (FMD) following 5-minute forearm ischemia of the right brachial artery. Endothelium-independent function was also assessed through nitrate-mediated dilation (NMD) of the right brachial artery in response to sublingual administration of 25 μg of nitroglycerin. Results: STD (h...
In multiple sclerosis, use of fingolimod reduced immune responses to influenza and tetanus booster vaccines
Authors: John R. Absher
Journal: Annals of Internal Medicine (2015)

ACP Journal Club16 June 2015In multiple sclerosis, use of fingolimod reduced immune responses to influenza and tetanus booster vaccinesJohn R. Absher, MD, FAANJohn R. Absher, MD, FAANAbsher Neurology, PA, and, Alliance for Neuro Research, LLC, Greenville, South Carolina, USA (J.R.A.)Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/ACPJC-2015-162-12-008 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail Source CitationKappos L, Mehling M, Arroyo R, et al. Randomized trial of vaccination in fingolimod-treated patients with multiple sclerosis. Neurology. 2015;84:872-9. https://pubmed.ncbi.nlm.nih.gov/25636714Clinical Impact RatingsGIM/FP/GP: Infectious Disease: Neurology: References1. Mehling M, Hilbert P, Fritz S, et al. Antigen-specific adaptive immune responses in fingolimod-treated multiple sclerosis patients. Ann Neurol. 2011;69:408-13. [PMID: 21387383] Google Scholar2. Boulton C, Meiser K, David OJ, Schmouder R. Pharmacodynamic effects of steady-state fingolimod on antibody response in healthy volunteers: a 4-week, randomized, placebo-controlled, parallel-group, multiple-dose study. J Clin Pharmacol. 2012;52:1879-90. [PMID: 22174429] Google Scholar3. Marrie RA, Elliott L, Marriott J, et al. Dramatically changing rates and reasons for hospitalization in multiple sclerosis. Neurology. 2014;83:929-37. [PMID: 25085638] Google Scholar4. Redelings MD, McCoy L, Sorvillo F. Multiple sclerosis mortality and patterns of comorbidity in the United States from 1990 to 2001. Neuroepidemiology. 2006;26:102-7. [PMID: 16374035] Google Scholar Author, Article, and Disclosure InformationAuthors: John R. Absher, MD, FAANAffiliations: Absher Neurology, PA, and, Alliance for Neuro Research, LLC, Greenville, South Carolina, USA (J.R.A.)This article was published at Annals.org on 2 June 2015. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byImmunization in multiple sclerosis and other childhood immune-mediated disorders of the central nervous system: A review of the literature 16 June 2015Volume 162, Issue 12Page: JC8KeywordsAntibodiesAntibody productionAttenuated vaccinesImmune responseImmunityMultiple sclerosisNeurologyTetanusToxoidsVaccines ePublished: 16 June 2015 Issue Published: 16 June 2015 Copyright & PermissionsCopyright © 2015 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
The Diagnosis of Gonococcal Arthritis With Report of Three Cases in Patients With Chronic Rheumatic Endocarditis
Authors: O. H. Perry Pepper
Journal: Annals of Internal Medicine (1929)

Article1 October 1929The Diagnosis of Gonococcal Arthritis With Report of Three Cases in Patients With Chronic Rheumatic EndocarditisO. H. PERRY PEPPER, M.D.O. H. PERRY PEPPER, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-3-4-328 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptNot so many years ago the term gonococcal arthritis connoted an ankylosing monarticular process; today we know that gonococcal arthritis is usually a polyarthritis which may so closely simulate rheumatic fever as to lead to diagnostic error unless one is constantly alert to suspect and search for the evidences of gonococcal infection.We have also learned that all prostatitis is not gonococcal nor need it have even started as such, and we have gained a hearty respect for both venereal and non-venereal prostatitis as a focal cause of such distant troubles as arthritis, iritis and neuritis.Notwithstanding these advances, it...1 Cooperman M: Am. J. Dis. Child., 1927, 33, 932. CrossrefGoogle Scholar2 Thomas BA: J. Am. Med. Assn., 1927, 89, 2147. CrossrefGoogle Scholar3 Blake FG: in Blumer's Bedside Diagnosis, Saunders, 1928. Google Scholar4 MondorUrbain : Comptes rend. Soc. de Biol., 1927, 96, 513 et al. Google Scholar5 Practical Text Book of Infection, etc., Saunders, 1923. Google Scholar6 Injuries and Diseases of the Bones and Joints: Hoeber, New York, 1927. Google Scholar7 Plisson L: Le Prog. Med., 1927, 42, 1543. Google Scholar8 Forkner CE; Bull. Johns Hopkins Hosp., 1928, 43, 257. Google Scholar9 Klinische Wochenschrift, 1927, 6, 732. CrossrefGoogle Scholar10 Torrey RG: Tice's System of Medicine. Google Scholar11 Blumer G: Bedside Diagnosis Volume 1, p. 32, Saunders, 1928. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Philadelphia*Read before the American College of Physicians, April 9, 1929, Boston, Mass. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byThe Rôle of the Roentgenologist in the Diagnosis and Treatment of Chronic ArthritisFernkomplikationen bei Gonorrhöe 1 October 1929Volume 3, Issue 4Page: 328-334KeywordsArthritisEndocarditisProstatitisRheumatic fever ePublished: 1 December 2008 Issue Published: 1 October 1929 PDF downloadLoading ...
Narrowband ultraviolet B and biologics in psoriasis
Authors: P. Calzavara-Pinton
Journal: British Journal of Dermatology (2011)

Journal Article Narrowband ultraviolet B and biologics in psoriasis Get access P. Calzavara‐Pinton P. Calzavara‐Pinton Department of Dermatology, University of Brescia, Brescia, Italy E‐mail: calzavar@med.unibs.it Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 166, Issue 1, 1 January 2012, Page 5, https://doi.org/10.1111/j.1365-2133.2011.10680.x Published: 01 January 2012
Arthritis Medications and Cardiovascular Events
Authors: Simeon Pollack
Journal: JAMA (2005)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Human CLP36, a PDZ-domain and LIM-domain protein, binds to α-actinin-1 and associates with actin filaments and stress fibers in activated platelets and endothelial cells
Authors: Kristin Bauer, Michael Kratzer, Marcus Otte, Karin Luber de Quintana, Jörg Hagmann, Georg J. Arnold, Christoph Eckerskorn, Friedrich Lottspeich, Wolfgang Siess
Journal: Blood (2000)
Glitazone Treatment and Incidence of Parkinson’s Disease among People with Diabetes: A Retrospective Cohort Study
Authors: Ruth Brauer, Krishnan Bhaskaran, Nishi Chaturvedi, David T. Dexter, Liam Smeeth, Ian Douglas
Journal: PLoS Medicine (2015)

Background Recent in vitro and animal experiments suggest that peroxisome proliferation-activated receptor gamma (PPARɣ) agonist medications, such as antidiabetic glitazone (GTZ) drugs, are neuroprotective in models of Parkinson’s disease (PD). These findings have not been tested in humans. We hypothesized that individuals prescribed GTZ drugs would have a lower incidence of PD compared to individuals prescribed other treatments for diabetes. Methods and Findings Using primary care data from the United Kingdom Clinical Practice Research Datalink (CPRD), we conducted a retrospective cohort study in which individuals with diabetes who were newly prescribed GTZ (GTZ-exposed group) were matched by age, sex, practice, and diabetes treatment stage with up to five individuals prescribed other diabetes treatments (other antidiabetic drug-exposed group). Patients were followed up from 1999 until the first recording of a PD diagnosis, end of observation in the database, or end of the study (1 August 2013). An incidence rate ratio (IRR) was calculated using conditional Poisson regression, adjusted for possible confounders. 44,597 GTZ exposed individuals were matched to 120,373 other antidiabetic users. 175 GTZ-exposed individuals were diagnosed with PD compared to 517 individuals in the other antidiabetic drug-exposed group. The incidence rate (IR) of PD in the GTZ-exposed group was 6.4 per 10,000 patient years compared with 8.8 per 10,000 patient years in those prescribed other antidiabetic treatments (IRR 0.72, 95% confidence interval [CI] 0.60–0.87). Adjustments for potential confounding variables, including smoking, other medications, head injury, and disease severity, had no material impact (fully adjusted IRR 0.75, 0.59–0.94). The risk was reduced in those with current GTZ prescriptions (current GTZ-exposed IRR 0.59, 0.46–0.77) but not reduced among those with past prescriptions (past GTZ-exposed IRR 0.85, 0.65–1.10). Our study only included patients with diabetes who did not have a PD diagnosis when they were first prescribed GTZ, and thus, it cannot establish whether GTZ use prevents or slows the progression of PD. Conclusions In patients with diabetes, a current prescription for GTZ is associated with a reduction in incidence of PD. This suggests PPAR gamma pathways may be a fruitful drug target in PD.
Characteristics of Fibromyalgia Independently Predict Poorer Long‐Term Analgesic Outcomes Following Total Knee and Hip Arthroplasty
Authors: Chad M. Brummett, Andrew G. Urquhart, Afton L. Hassett, Alex Tsodikov, Brian R. Hallstrom, Nathan I. Wood, David A. Williams, Daniel J. Clauw
Journal: Arthritis & Rheumatology (2015)

Objective While psychosocial factors have been associated with poorer outcomes after knee and hip arthroplasty, we hypothesized that augmented pain perception, as occurs in conditions such as fibromyalgia, may account for decreased responsiveness to primary knee and hip arthroplasty. Methods A prospective, observational cohort study was conducted. Preoperative phenotyping was conducted using validated questionnaires to assess pain, function, depression, anxiety, and catastrophizing. Participants also completed the 2011 fibromyalgia survey questionnaire, which addresses the widespread body pain and comorbid symptoms associated with characteristics of fibromyalgia. Results Of the 665 participants, 464 were retained 6 months after surgery. Since individuals who met criteria for being classified as having fibromyalgia were expected to respond less favorably, all primary analyses excluded these individuals (6% of the cohort). In the multivariate linear regression model predicting change in knee/hip pain (primary outcome), a higher fibromyalgia survey score was independently predictive of less improvement in pain (estimate −0.25, SE 0.044; P &lt; 0.00001). Lower baseline joint pain scores and knee (versus hip) arthroplasty were also predictive of less improvement (R 2 = 0.58). The same covariates were predictive in the multivariate logistic regression model for change in knee/hip pain, with a 17.8% increase in the odds of failure to meet the threshold of 50% improvement for every 1‐point increase in fibromyalgia survey score ( P = 0.00032). The fibromyalgia survey score was also independently predictive of change in overall pain and patient global impression of change. Conclusion Our findings indicate that the fibromyalgia survey score is a robust predictor of poorer arthroplasty outcomes, even among individuals whose score falls well below the threshold for the categorical diagnosis of fibromyalgia.
Diagnostic Value of Endoscopic Capsule in Patients with Obscure Digestive Bleeding: Blinded Comparison with Video Push-Enteroscopy
Authors: J-C Saurin, M Delvaux, J-L Gaudin, I Fassler, J Villarejo, K Vahedi, A Bitoun, J-M Canard, J C Souquet, T Ponchon, C Florent, G Gay
Journal: Endoscopy (2003)

This study was designed to prospectively compare the diagnostic yield of the M2A endoscopic capsule with that of video push-enteroscopy in exploring the small intestine in patients with obscure digestive bleeding.Patients with either occult or overt obscure digestive bleeding and a negative endoscopic work-up underwent a double intestinal investigation, with video push-enteroscopy and a wireless capsule, performed blindly by separate examiners. The diagnostic yield for each technique was defined as the frequency of detection of clinically relevant intestinal lesions, i. e. those having the potential for bleeding.60 patients (27 men, 33 women; age 58 +/- 18 years; hemoglobin 9.4 +/- 2.5 g/dl) were included, 32 with occult and 28 with overt bleeding. Results were analyzed for 58 patients, who completed both examinations. Lesions were detected in 43 patients: with both techniques in 19, only by capsule in 21, and, conversely, only by push-enteroscopy in 3 ( P = 0.04). Final diagnoses were as follows: a P2 lesion with high bleeding potential in 28 patients (19 angiomata, 6 ulcerations, 2 tumors, 1 case of intestinal varices); a P1 lesion with intermediate bleeding potential in 15 patients (2 patients with mucosal erosions, 13 patients with mucosal red spots); and there were normal findings from 15 procedures. No procedure induced any complication.The use of the wireless endoscopy capsule detects significantly more clinically relevant intestinal lesions than video push-enteroscopy in patients with obscure digestive bleeding, raising the diagnostic yield to 67.2 %. Its influence on the clinical outcome for patients needs further investigation.
Publicly Reporting Quality Information
Authors: Edward L Hannan, Mark R Chassin
Journal: JAMA (2005)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Tumor Necrosis Factor Receptor Deficiency Alters Matrix Metalloproteinase 13/Tissue Inhibitor of Metalloproteinase 1 Expression in Murine Silicosis
Authors: LUIS A. ORTIZ, JOSEPH LASKY, EVELYNE GOZAL, VICTOR RUIZ, GIUSEPPE LUNGARELLA, ELEONORA CAVARRA, ARNOLD R. BRODY, MITCHELL FRIEDMAN, ANNIE PARDO, MOISES SELMAN
Journal: American Journal of Respiratory and Critical Care Medicine (2001)

Murine exposure to silica is associated with enhanced tumor necrosis factor alpha (TNF-alpha) expression and matrix deposition. The regulation of TNF is mediated through TNF receptor (TNFR) activation of transcription factors. In the present work we have studied the importance of the individual TNFR in silica-induced lung inflammation and matrix deposition in mice. We studied RNA expression of TNF, alpha1(I) collagen, interstitial collagenase (MMP-13), and its inhibitor (TIMP-1) in the lungs of silica-treated mice. Furthermore, we correlated MMP-13/TIMP-1 RNA abundance with activation of the transcription factors AP-1 and NF-kappaB in the lungs of C57BL/6 mice, and of mice deficient in one of the two types of TNFR (p55(-/-) or p75(-/-)), exposed to silica (0.2 g/kg) or saline by intratracheal instillation. Animals were killed 28 d after exposure and lung hydroxyproline (HP), TNF, alpha1(I) collagen, MMP-13, and TIMP-1 RNA abundance was measured. AP-1 and NF-kappaB activation was studied by gel-shift assays. Compared with C57BL/6 mice, p55(-/-) and p75(-/-) mice significantly (*p < 0.05) decreased lung HP accumulation in response to silica. All murine strains enhanced TNF and alpha1(I) collagen mRNA in response to silica. Enhanced (p < 0.05) MMP-13 RNA expression was also observed in all murine strains in response to silica. Enhanced (p < 0.05) TIMP-1 RNA expression was observed in C57BL/6 mice, but not in p55(-/-) or p75(-/-) mice, in response to silica. NF-kappaB activation was observed in all murine strains, whereas AP-1 activation was observed only in C57BL/6 mice after silica treatment. These data suggest that TNFR deletion modifies MMP-13/ TIMP-1 expression in favor of matrix degradation.
Vitamin A analogue protects against breast cancer
Authors: Janice Hopkins Tanne
Journal: BMJ (1999)

A synthetic vitamin A analogue, fenretinide, reduced the rate of second breast cancers in premenopausal women in a study by Dr Umberto Veronesi of the Istituto Nazionale Tumori and the European Institute of Oncology in Milan and colleagues ( Journal of the National Cancer Institute 1999;91:1847-56).

In postmenopausal women, however, it seemed to increase the risk of a second breast cancer. The drug also reduced the rate of ovarian cancer in women under 50.

“Chemoprevention is relatively new. The carcinogenic process is multi-step and this substance might interfere with and stop the process,” said Dr Veronesi at a press conference …
Spectrum of mutations in the<i>ANTXR2</i>(<i>CMG2</i>) gene in infantile systemic hyalinosis and juvenile hyaline fibromatosis
Authors: G.Y. El-Kamah, K. Fong, M. El-Ruby, H.H. Afifi, S.E. Clements, J.E. Lai-Cheong, K. Amr, M. El-Darouti, J.A. McGrath
Journal: British Journal of Dermatology (2010)

Table S1. Published mutations in ANTXR2 (CMG2) and their clinical consequences. Please note: Wiley-Blackwell are not responsible for the content or functionality of any supporting materials supplied by the authors. Any queries (other than missing material) should be directed to the corresponding author for the article. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
Medical Issues and Ramadan
Authors: Kazim Sheikh
Journal: JAMA (2006)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2022 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal