tbuckley/cabot-search huggingface dataset:
873 LOW PRE-TREATMENT NUMBERS OF CD4+/PD-1+ LYMPHOCYTES AND T REGULATORY LYMPHOCYTES PREDICT SUCCESSFUL RESPONSE TO PEGYLATED- INTERFERON/RIBAVIRIN THERAPY IN CHILDREN WITH CHRONIC HEPATITIS C (CH-C)
Authors: I. Carey, D. Cebecauerova, S. Bansal, M.S. Longhi, P. Subramaniam, G. Mieli-Vergani, D. Vergani
Journal: Journal of Hepatology (2009)
Endometrial VEGF induces placental sFLT1 and leads to pregnancy complications
Authors: Xiujun Fan, Anshita Rai, Neeraja Kambham, Joyce F. Sung, Nirbhai Singh, Matthew Petitt, Sabita Dhal, Rani Agrawal, Richard E. Sutton, Maurice L. Druzin, Sanjiv S. Gambhir, Balamurali K. Ambati, James C. Cross, Nihar R. Nayak
Journal: Journal of Clinical Investigation (2014)

There is strong evidence that overproduction of soluble fms-like tyrosine kinase-1 (sFLT1) in the placenta is a major cause of vascular dysfunction in preeclampsia through sFLT1-dependent antagonism of VEGF. However, the cause of placental sFLT1 upregulation is not known. Here we demonstrated that in women with preeclampsia, sFLT1 is upregulated in placental trophoblasts, while VEGF is upregulated in adjacent maternal decidual cells. In response to VEGF, expression of sFlt1 mRNA, but not full-length Flt1 mRNA, increased in cultured murine trophoblast stem cells. We developed a method for transgene expression specifically in mouse endometrium and found that endometrial-specific VEGF overexpression induced placental sFLT1 production and elevated sFLT1 levels in maternal serum. This led to pregnancy losses, placental vascular defects, and preeclampsia-like symptoms, including hypertension, proteinuria, and glomerular endotheliosis in the mother. Knockdown of placental sFlt1 with a trophoblast-specific transgene caused placental vascular changes that were consistent with excess VEGF activity. Moreover, sFlt1 knockdown in VEGF-overexpressing animals enhanced symptoms produced by VEGF overexpression alone. These findings indicate that sFLT1 plays an essential role in maintaining vascular integrity in the placenta by sequestering excess maternal VEGF and suggest that a local increase in VEGF can trigger placental overexpression of sFLT1, potentially contributing to the development of preeclampsia and other pregnancy complications.
Familial atrophia maculosa varioliformis cutis
Authors: P.M. Gordon, V.R. Doherty
Journal: British Journal of Dermatology (1996)

Journal Article Familial atrophia maculosa varioliformis cutis Get access P.M. Gordon, P.M. Gordon Department of Dermatology Victoria Hospital Kirkcaldy Fife, U.A. Search for other works by this author on: Oxford Academic Google Scholar V.R. Doherty V.R. Doherty Department of Dermatology Victoria Hospital Kirkcaldy Fife, U.A. Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 134, Issue 5, 1 May 1996, Pages 982–983, https://doi.org/10.1111/j.1365-2133.1996.tb06345.x Published: 01 May 1996
A CASE OF PHLEGMONOUS GASTRITIS
Authors: A. J. Hall, G. Simpson
Journal: BMJ (1908)

THE difficulties which may be experienced in locating an abseess deeply placed within the chest, and the compara- tive rarity of complete success in the treatment of this condition, seem to us sufficient reasons for placing the following case on record.W. S., aged 36, previously strong and healthy, was taken ill in July, 1907.He was engaged on night duty ln' a brewery, and besides having very hard work was exposed to sudden changes of temperature.There was no evidence of excessive indulgence in alcohol.His illness commenced gradually with cough and weakness.Afterwards he had several shivering attacks, with pain in the back, shortness of breath, and couge,.He was [now attended by Dr. Hbillof Old Basford, who informs us he detected signs of pleuro-pneumonia followed by effusion into the left pleura.This disappeared, but, after the patient had been laid up seven weeks, ne began to expectorate large quantities of pinkish tenacious sputum, which afterwards assumed the appearance of ordinary pus.Notwithstacoding this, he attempted to get about, but suffered from pain, with swelling of the legs and feet, also from cough and shortness of breath.He was admitted into the Nottingham General Hospital on September 18:b, having been ill over two months.HA was pale and wasted; mucous membranes of good colour.Welght 8 at., which speedily declined to 7 st.11 lb., at -wbich It remained with slight variations until December 14tb.Pulse 124, regular, low tension.Respiratoions 28 The temperature was hectic, ranging from 980 to 1010 or 1020.The sputum continued copious until the date of the operation (December 14th), consisting of inodorous, thin, frothy pus, the quantity varying from 4 to 18 cz.An examination for tuberole bacilli was negative.The patient always expreseed himself as feeling comfortable, but was obliged to lie in a very constrained position-namely, on the right side, with the hFad near the edge of the bed.Doubtless this facilitated drainage of the cavity, since any attempt to lie on the back or left side caused uncontrollable cough.Phdsical Signs.Heart: The apex beat could not be seen or felt.The sounds were normal, and the organ was not displaced.Lungs (left side): Movement impaired; deficient resonance over the whole of the left lung, most marked at the lower part of the axilla, and near the angle of the scapula.Breath sounds everywhere weak, especially below the angle of the scapula, although vooal resonance was present In this position.At the ape;* below the nipple; and near tbe angle of the scapula, the breath sounds were distant and bronchial.There were soattered, small crepitations all over the left side, whtch were Further Cases not included in Moynihaan's List.
Primary Child Care: A Manual for Health Workers
Authors: Susie Reitz
Journal: JAMA (1979)

"Don't read it from the beginning to the end" wisely advise the authors in the introduction to this reference manual. As the title says, health workers, not physicians, are most aided by this inexpensive volume, which contains commonsense advice and helpful illustration. However, the reader may have difficulty wading through the clutter of several sizes and styles of typeface as well as the inconsistent illustration. The book's chief problem is its distracting layout. This manual could be useful for primary care physicians, but it is geared for allied health personnel, especially those in training. The simplified explanations describe conditions and give advice in layman's terms and could not be used as the last word for physicians struggling with differential diagnoses. More detailed definitive works are available. Personnel in primary care clinics and public schools, who deal regularly with children, may find this book helpful. Another interested audience would be parents
ANAESTHESIA IN TONSIL AND ADENOID OPERATIONS
Authors: C. Yorke
Journal: BMJ (1920)

TaIn any case the appendix is not of vital importance-in health at least; it is true that a proportion of patients who have had appendicectomy performed suffer afterwards from constipation, but, as will be shown in the series considered in another paper, the disability in uncomplicated cases is seldom great and generally tends to right itself with time.REFERENCES.
A20 Restricts Ubiquitination of Pro-Interleukin-1β Protein Complexes and Suppresses NLRP3 Inflammasome Activity
Authors: Bao H. Duong, Michio Onizawa, Juan A. Oses-Prieto, Rommel Advincula, Alma Burlingame, Barbara A. Malynn, Averil Ma
Journal: Immunity (2015)
Riding Chaucer in the Stirrups
Authors: Sophie Hughes
Journal: JAMA (1995)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Sodium nitrite protects against kidney injury induced by brain death and improves post-transplant function
Authors: Stacey S. Kelpke, Bo Chen, Kelley M. Bradley, Xinjun Teng, Phillip Chumley, Angela Brandon, Brett Yancey, Brandon Moore, Hughston Head, Liliana Viera, John A. Thompson, David K. Crossman, Molly S. Bray, Devin E. Eckhoff, Anupam Agarwal, Rakesh P. Patel
Journal: Kidney International (2012)
941. Delayed GDNF Exposure to Mature Dopaminergic Grafts Impairs Their Ability To Improve Motor Function in Parkinsonian Rats
Authors: Biljana Georgievska, Christian Winkler, Thomas Carlsson, Benjamin Lacar, Deniz Kirik
Journal: Molecular Therapy (2005)

Top of pageAbstract
Functional effects of ventral mesencephalic (VM) cell transplants in models of Parkinson's disease are limited by the survival and fiber outgrowth of the grafted cells. In a recent study, we used a recombinant lentiviral vector (rLV) encoding glial cell line-derived neurotrophic factor (GDNF) for gene delivery to the chronically dopamine (DA)-depleted striatum, in order to test whether long-term GDNF support could increase the cell survival, fiber density innervation and thereby also the functional benefits from intrastriatal VM grafts (Georgievska et al., EJN 20(11):3121-3130, 2004). Grafting of VM cells into the GDNF-overexpressing striatum provided a 2-fold increase in the number of surviving DA neurons at 4 weeks, however, the initially protected cells failed to survive at 6 months post-grafting, despite the continued presence of GDNF. In addition, GDNF induced a selective downregulation of tyrosine hydroxylase (TH) in the graft-derived fibers and the GDNF treatment failed to provide any additional recovery in spontaneous motor performance. The aim of the present study was to evaluate whether continuous long-term expression of GDNF could improve the functional efficacy of maturated VM grafts. For this purpose, chronically 6-hydroxydopamine (6-OHDA) lesioned rats first received multiple intrastriatal VM transplants, followed 3 months later by injections of rLV-GDNF into the striatum. Thus, GDNF treatment of the grafts was initiated at 3 months after transplantation, i.e. at a time when the grafts are fully integrated into the host brain. Stereological quantification of the number of TH+ cells in the grafts at 6 months after transplantation (i.e. after 3 months of GDNF exposure) showed a similar cell survival in both groups (GDNF vs. GFP). Striatal fiber innervation was estimated using densitometry analyses on sections immunostained for TH and the vesicular monoamine transporter-2 (VMAT2). In non-grafted lesioned animals the TH+ and VMAT2+ fiber innervation was 10% and 20% of control side, respectively. The TH+ fiber innervation density was lower in the GDNF-treated grafted animals (22% of normal) compared to control (GFP) grafts (39% of normal), whereas the VMAT2+ fiber density was equal in both groups, suggesting a selective downregulation of TH in the graft-derived DA fibers. Behavioral analyses at 6 months after transplantation demonstrated that control grafted animals improved to about 40-60% of normal performance in the stepping and cylinder test. By contrast, GDNF-treated animals failed to show any significant improvement in these spontaneous motor tests. Our data suggest that GDNF treatment of mature DA grafts impairs their ability to provide functional recovery in parkinsonian rats.
Mutations in MFSD8, Encoding a Lysosomal Membrane Protein, Are Associated with Nonsyndromic Autosomal Recessive Macular Dystrophy
Authors: Susanne Roosing, L. Ingeborgh van den Born, Riccardo Sangermano, Sandro Banfi, Robert K. Koenekoop, Marijke N. Zonneveld-Vrieling, Caroline C.W. Klaver, Janneke J.C. van Lith-Verhoeven, Frans P.M. Cremers, Anneke I. den Hollander, Carel B. Hoyng
Journal: Ophthalmology (2014)
Inflammatory Cytokines Induce Phosphorylation and Ubiquitination of Prostate Suppressor Protein NKX3.1
Authors: Mark C. Markowski, Cai Bowen, Edward P. Gelmann
Journal: Cancer Research (2008)

Abstract Inflammation of the prostate is a risk factor for the development of prostate cancer. In the aging prostate, regions of inflammatory atrophy are foci for prostate epithelial cell transformation. Expression of the suppressor protein NKX3.1 is reduced in regions of inflammatory atrophy and in preinvasive prostate cancer. Inflammatory cytokines tumor necrosis factor (TNF)-α and interleukin-1β accelerate NKX3.1 protein loss by inducing rapid ubiquitination and proteasomal degradation. The effect of TNF-α is mediated via the COOH-terminal domain of NKX3.1 where phosphorylation of serine 196 is critical for cytokine-induced degradation. Mutation of serine 196 to alanine abrogates phosphorylation at that site and the effect of TNF-α on NKX3.1 ubiquitination and protein loss. This is in contrast to control of steady-state NKX3.1 turnover, which is mediated by serine 185. Mutation of serine 185 to alanine increases NKX3.1 protein stability by inhibiting ubiquitination and doubling the protein half-life. A third COOH-terminal serine at position 195 has a modulating effect on both steady-state protein turnover and on ubiquitination induced by TNF-α. Thus, cellular levels of the NKX3.1 tumor suppressor are affected by inflammatory cytokines that target COOH-terminal serine residues to activate ubiquitination and protein degradation. Our data suggest that strategies to inhibit inflammation or to inhibit effector kinases may be useful approaches to prostate cancer prevention. [Cancer Res 2008;68(17):6896–901]
ECTOPIC GESTATION — REPORT OF A CASE.
Authors: JOHN LAUGHLIN
Journal: JAMA (1896)

My reasons for reporting this case are because of many extraordinary conditions that maintained in its ten months' history and the remarkable recovery, the completeness of which was demonstrated by an operation for a complication. Mrs. E. N., aged 36, the mother of four children, the youngest 4 years of age; no miscarriages. Her menstruation began in her sixteenth year. The flow was abundant and it came about every three weeks. Twelve years ago the menstruation disappeared for four months. A tumor came in the right lumbar region and it was aspirated of a large amount of offensive material by Dr. McClure, now deceased. Her health continued fair until the fall of 1893. She said her menstrual periods were a little more prolonged and painful than common and a physician was consulted. In November, while going to church, she had a sudden attack of abdominal pain accompanied by weakness. After
"A Place to Clean the Teeth Needed in Railroad Car."
Authors: Samuel Ayres
Journal: JAMA (1901)

Pittsburg, Pa., Nov. 23, 1901. <h3>To the Editor:</h3> —The communication of Dr. Henry D. Fulton inThe Journalof November 9, on the needs of a proper place for cleaning the teeth in the toilet room of sleeping cars, and your own observations on the subject, in the same issue, are most timely and important. While every traveler with any sense of refinement must have regarded this filthy practice with disgust, that is, the spitting and cleaning of the teeth in bowls that are used for washing the face, it is strange that no protest has been entered against it or remedy suggested. Surely the ingenuity of the modern car-builder could quickly devise a remedy if the public would only insist on it. I have not for many years used these bowls nor any other bowls in public places for washing purposes, but always wash with the running water from
Anomalous neutrophil granule distribution in a patient with lactoferrin deficiency: Pertinence to the respiratory burst
Authors: Niels Borregaard, Laurence A. Boxer, James E. Smolen, Alfred I. Tauber
Journal: American Journal of Hematology (1985)

Abstract Neutrophils from a patient with lactoferrin deficiency were examined and the quantity and subcellular localization of protein markers were determined on Percoll density gradients. Distribution of azurophilic and specific granule markers was abnormal in that azurophilic granules were lighter than normal and appeared in the fraction of the gradient where normally the specific granules sediment. The specific granule membrane markers, cytochrome b ‐235 and its associated flavoprotein, were abnormally distributed in the γ fraction, the site of the plasma membrane marker alkaline phosphatase. Thus, the b‐cytochrome‐flavoprotein complex had either been incorporated into the plasma membrane or was still present in the membranes of granules that were abnormally light and cosedimented with the plasma membranes. This is of particular interest in regard to the patient's respiratory burst oxidase function, since the b‐cytochrome/flavoprotein complex normally translocates from the specific granules to the plasma membrane to constitute the active respiratory burst oxidase. The functional consequences of this abnormal distribution are discussed, as is the importance of characterizing both intragranular enzymatic markers and granule membrane proteins to define granular disorders.
When Is Breastfeeding Not Best?
Authors: Mary Glenn Fowler, Jeanne Bertolli, Philip Nieburg
Journal: JAMA (1999)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Interleukin 7 enhances cytolytic T lymphocyte generation and induces lymphokine-activated killer cells from human peripheral blood.
Authors: M R Alderson, H M Sassenfeld, M B Widmer
Journal: The Journal of Experimental Medicine (1990)

The effects of purified recombinant interleukin 7 (IL-7) on the generation of cytolytic T lymphocytes (CTL) in mixed lymphocyte culture (MLC) and on the induction of lymphokine-activated killer (LAK) cells in autologous cultures of human peripheral blood mononuclear cells were investigated. IL-7 was found to induce the generation of both CTL and LAK cells in bulk cultures. The appearance of peak CTL activity in MLC established with exogenous IL-7 was delayed in comparison with replicate cultures containing exogenous IL-2, but both cytokines stimulated quantitatively similar levels of antigen-specific lytic activity. An IL-2-neutralizing antiserum inhibited substantially, but not completely, the effect of IL-7 on CTL generation, implying the existence of both an indirect component of IL-7 activity via IL-2 utilization, as well as an IL-2-independent component. Cell surface phenotypic analysis of IL-2- or IL-7-generated CTL effector cells revealed that CD8+ cells were responsible for the vast majority of lytic activity. Limiting dilution analysis (LDA) revealed that essentially identical frequencies of CTL precursors (CTL-P) were capable of clonal expansion and/or differentiation in the presence of exogenous IL-2, IL-4, or IL-7, supporting the concept that all three of these cytokines are capable of exerting a major influence on T cell growth and differentiation. Approximately half of the CTL-P that responded in IL-7-supplemented LDA cultures did so in an IL-2-independent manner. IL-7 stimulated the development of LAK cells in autologous bulk cultures, but only weakly in comparison with IL-2. In contrast to its effects on CTL generation, the induction of LAK cells by IL-7 was virtually independent of IL-2. LAK cells induced by IL-7, like those induced by IL-2, were phenotypically heterogeneous and included CD8+, CD56+, and gamma/delta+ cells. Limiting dilution analysis indicated that IL-2 stimulated fivefold more LAK-P than IL-7 and 220-fold more than IL-4. Collectively, these data suggest that IL-7 has potent regulatory effects on human cytolytic cell populations and, either alone or in combination with other cytokines, could be important for the in vitro expansion of cells for adoptive immunotherapy.
Sepsis in Relation to Tumours
Authors: P. Browning
Journal: BMJ (1948)

The occasional occurrence of sepsis in surgical wounds maintained under rigid aseptic conditions leads to the inference that such infection can take place by routes other than direct contact from without.Learmonth (1924) described invasion of undamaged muscle of an arm by Clostridium welchii following a partial gastrectomy.Okell and Elliott (1935) demonstrated the transient presence in the blood of organisms associated with oral sepsis.Buchanan and Kyles (see C. H. Browning, 1944) by repeated blood cultures showed the occurrence of bacteriaemia after minor surgical intervention in a limited area where infection is present, as, for example, in the extraction of teeth.Such circulating organisms are no doubt usually disposed of rapidly by the blood, as indicated by the work of Wright and Douglas (1903), but where persistent bacteriaemia exists
T cell receptor‐Vβ repertoire in allergen‐specific sensitization and increased airway responsiveness
Authors: H. Renz
Journal: Allergy (1995)

An animal model system was developed to study the mechanisms resulting in allergic sensitization. Local allergen exposure via the airways and the lung stimulated an allergen‐specific immunoglobulin E (IgE) response that was paralleled by the development of increased airway responsiveness (AR). It was found that CD4 + T cells of local draining lymph nodes played an important role in the regulation of these events. Stimulation of allergen‐specific T cells requires interaction between major histocompatibility complex (MHC) class II molecules (expressed on antigen‐presenting cells), peptide (presented on MHC) and the T cell receptor. Allergen sensitization stimulated T cells that expressed a restricted T cell receptor Vβ (TCR‐Vp) elements. Each allergen stimulated different Vβ elements, and sensitization to the same allergen resulted in a different pattern of TCR‐Vβ stimulation in different lymphoid tissues. Some of these T cells had pro‐allergenic effects, whereas others were able to inhibit the development of the allergic response, including the development of increased AR. These data indicate that the local T cell response regulates the type of immune response that evolves following local allergen sensitization.