tbuckley/cabot-search huggingface dataset:
Autocrine release of interleukin-9 promotes Jak3-dependent survival of ALK+ anaplastic large-cell lymphoma cells
Authors: Lin Qiu, Raymond Lai, Quan Lin, Esther Lau, David M. Thomazy, Daniel Calame, Richard J. Ford, Larry W. Kwak, Robert A. Kirken, Hesham M. Amin
Journal: Blood (2006)
Midwifery and body fluid contamination.
Authors: J. J. Kabukoba, P. Young
Journal: BMJ (1992)

over eight years, which could not now be repeated as an untreated control would be considered unethical.Mortality data from the trial showed a significant reduction in fatal myocardial infarction in the treatment group.'The reduction in serum cholesterol concen- tration observed is of a magnitude which should be advantageous.We conclude that tamoxifen significantly reduces the serum cholesterol concentration in postmenopausal women with breast cancer.This drug, used to control one major cause of mortality in women, is found to be benefiting risk factor status for another.It may be worth exploring the potential of tamoxifen or its analogues as cholesterol lowering agents.
Influence of levocabastine suspension on ciliary beat frequency and mucociliary clearance
Authors: F. W. H. M. Merkus, M. T. I. W. Schüsler‐van Hees
Journal: Allergy (1992)

The effects of levocabastine, a new fast-acting, highly potent H1-antagonist, on nasal ciliary epithelial function were investigated in an in vitro and in vivo study. In the in vitro study, a suspension of levocabastine in Locke-Ringer solution was applied to 10 bioptic specimens of ciliated human adenoid tissue. Each specimen was exposed to the test solution for 60 min. Ciliary beat frequency (CBF) was recorded with a photoelectric recording device at 10-min intervals. There were small, insignificant decreases in CBF, which were minimal compared to that observed with ciliotoxic agents. In the in vivo study, 8 healthy volunteers were given, intranasally, one droplet of the levocabastine suspension. Mucociliary transit time (MTT) was measured by placing a saccharin particle drenched in indigo carmine in the nose just below the top of the concha and measuring the time until appearance of the dye in the pharyngeal cavity. No statistically significant differences were found in the MTT before and after application of the levocabastine suspension. The studies thus indicate that nasally administered levocabastine does not interfere with ciliary beat frequency and mucociliary function.
Low-Cost Lessons from Grand Junction, Colorado
Authors: Thomas Bodenheimer, David West
Journal: New England Journal of Medicine (2010)

In August 2009, President Barack Obama traveled to Grand Junction, Colorado, touting that community's health care system as a model for the provision of low-cost, high-quality care. According to the Dartmouth Atlas of Health Care, average per capita Medicare spending in Grand Junction was $6,599 in 2007 — 24% lower than the national average and 60% below high-cost Miami. In 2005, Grand Junction had only 60% as many coronary-artery bypass surgeries in its Medicare population as the national average, 55% as many inpatient coronary angiography procedures, and 61% as many inpatient days during the last 2 years of life. Moreover, . . .
Hyperthermia During Anesthesia
Authors: Lawrence J. Saidman, Everette S. Havard, Edmond I. Eger
Journal: JAMA (1964)

The development of hyperthermia in an anesthetized patient can be a serious threat to the patient's life. Once the temperature rise begins, it proceeds at an ever increasing rate. It may go unrecognized until a sudden deterioration in the patient's condition calls attention to his plight. The physiologic abnormalities associated with the hyperthermia include dehydration, hypotension, hypoxia, and acidosis. Treatment must be prompt if irreversible tissue damage or death are to be avoided, and includes rapid cooling, rehydration, and correction of the electrolyte and acid-base abnormalities. Prevention must include adequate evaluation and treatment of preoperative temperature elevations and hypermetabolic states. Use of intraoperative temperature monitoring would enable the anesthesiologist to recognize and treat the elevated temperature before it climbed seriously high and led to physiological decompensation.
Charles Geoffrey Sykes
Authors: P. Sykes
Journal: BMJ (2010)

Charles Geoffrey Sykes (“Geoff”) was born at Fartown in Huddersfield in 1922. He was educated locally and at Almondbury Grammar School, Huddersfield. After school he studied medicine at Leeds Medical School, graduating in 1948. He joined the Royal Air Force as a doctor and was based in Lincolnshire, where, in addition to providing medical services, he enjoyed taking the occasional trip in a Lancaster bomber. He was also seconded for a period to the American Air Force. He never forgot the warmth with which the American servicemen welcomed him, his memories of this period of his life remaining very special.

After national service, Geoff returned to Yorkshire, and in 1955 he married …
Children With Chronic Arthritis: A Primer for Patients and Parents
Authors: Burton J. Grossman
Journal: JAMA (1982)

This book is the outgrowth of the author's perception that "the successful outcome of any chronic illness is predicated on a critical role of responsibility played by the patient." The book is written for patients and parents who feel a need to share with their physicians some background of elementary knowledge concerning what little is known of biologic mechanisms and the principles of present-day treatment of rheumatic diseases of childhood. Attention is focused on juvenile rheumatoid arthritis (JRA) as an example. The author uses two chapters to describe JRA and related diseases. The third chapter explores the many questions that may arise in the minds of the patients. Chapters 4 through 7 describe "some useful facts" on anatomy, physiology, immunity, and pathology relating directly to JRA and similar illnesses. Chapters 8, 9, and 10 are a description of the various onsets of JRA. Chapter 11 is a rather thorough description
Technical standards for hepatitis B virus X protein (HBx) research
Authors: Betty L. Slagle, Ourania M. Andrisani, Michael J. Bouchard, Caroline G.L. Lee, J.‐H. James Ou, Aleem Siddiqui
Journal: Hepatology (2014)

Chronic infection with hepatitis B virus (HBV) is a risk factor for developing hepatocellular carcinoma (HCC). The life cycle of HBV is complex and has been difficult to study because HBV does not infect cultured cells. The HBV regulatory X protein (HBx) controls the level of HBV replication and possesses an HCC cofactor role. Attempts to understand the mechanism(s) that underlie HBx effects on HBV replication and HBV-associated carcinogenesis have led to many reported HBx activities that are likely influenced by the assays used. This review summarizes experimental systems commonly used to study HBx functions, describes limitations of these experimental systems that should be considered, and suggests approaches for ensuring the biological relevance of HBx studies.
Gujarat earthquake causes major mental health problems
Authors: R. Sharma
Journal: BMJ (2002)

Last year's earthquake in Gujarat, which occurred a year ago last Saturday, resulted in widespread but neglected mental health problems, a conference of non-governmental organisations and mental health specialists meeting in Ahmedabad, India, concluded last week.

The massive earthquake killed between 14 000 and 20 000 people, damaged over 1.2 million houses, and affected almost 8000 villages in Gujarat, west India. More than 3000 health facilities were destroyed, including a 281 bed district hospital, a 16 bed …
Large intergenic non-coding RNA-RoR modulates reprogramming of human induced pluripotent stem cells
Authors: Sabine Loewer, Moran N Cabili, Mitchell Guttman, Yuin-Han Loh, Kelly Thomas, In Hyun Park, Manuel Garber, Matthew Curran, Tamer Onder, Suneet Agarwal, Philip D Manos, Sumon Datta, Eric S Lander, Thorsten M Schlaeger, George Q Daley, John L Rinn
Journal: Nature Genetics (2010)
An In Vivo Assessment of Factor VIII Concentrates
Authors: G. Rock
Journal: JAMA (1985)

Replacement therapy for patients with hemophilia A requires that a specific dose of factor VIII be administered. Generally, these calculations involve the use of the manufacturer's stated dose in an equation. We have assessed factor VIII concentrates by in vitro techniques and found a considerable discrepancy (35%) between the stated and the measured contents. Confirmation of this discrepancy was obtained by in vivo assessment where posttransfusion recoveries corresponded to the measured rather than the stated contents of the vial. The half-disappearance time ranged from five to eight hours. The data suggest that constant monitoring of factor VIII preparations is necessary to ensure optimal treatment of patients with hemophilia A and help to explain the recent efforts by the Office of Biologics to achieve standardization.
A Filipino Patient With Fulminant Type 1 Diabetes
Authors: Matsuo Taniyama, Ryo Katsumata, Kanemi Aoki, Seiji Suzuki
Journal: Diabetes Care (2004)

Fulminant type 1 diabetes is characterized by abrupt onset of loss of pancreas β-cell function with low initial HbA1c levels and absence of autoantibodies to islet antigens (1). Initial histological examinations revealed the absence of insulitis, and it was thought that the autoimmune process did not mediate this type of diabetes. However, with an accumulation of cases, possible involvement of an immune response to islet antigens has come to light. CD8+ lymphocytes infiltrating the pancreatic islets were seen in a patient who died of fulminant type 1 diabetes (2), and peripheral GAD-reactive interferon-γ-producing CD4+ lymphocytes were detected in another case of fulminant type 1 diabetes (3). Thus, T-cell-mediated autoimmunity may be involved. HLA analyses also indicate that an autoimmune process similar to that in autoimmune type …
Public policy and mental health legislation should be reconsidered
Authors: F. Holloway, G. Szmukler
Journal: BMJ (1999)

Intranasal corticosteroids in allergic rhinitis Paper did not include all data on adverse effectsEditor-Weiner et al conclude that "results from [their] systematic review, together with data on safety and cost effectiveness, support the use of intranasal corticosteroids over oral antihistamines as first line treatment for allergic rhinitis." 1 They also state that "intranasal corticosteroids are considered safe [and] studies have failed to show significant effects on serum markers of bone metabolism and short term bone growth," referring to two studies, those by Martinati et al and Wolthers et al.They make no reference to two more recent studies, both of a larger number of subjects over longer periods, which established a significant reduction in paediatric bone growth. 2 3The issue of adverse effects was also addressed in a report by the Committee on Safety of Medicines and Medicines Control Agency, which concluded that intranasal corticosteroids can cause "clinically important systemic adverse effects at licensed doses." 4 The United Kingdom datasheet for Beconase aqueous nasal spray (beclomethasone dipropionate) recognises the potential for children to develop growth retardation at licensed doses and the need to refer patients to paediatric specialists while they are being prescribed intranasal corticosteroids (Allen and Hanburys, Sept 1998).I question the omission of such key data from Weiner et al's systematic review; it may well tip the risk:benefit ratio away from the use of intranasal corticosteroids in children and, hence, affect the validity of the review's conclusions.
Pioglitazone Decreases Carotid Intima-Media Thickness Independently of Glycemic Control in Patients With Type 2 Diabetes Mellitus
Authors: M.R. Langenfeld, T. Forst, C. Hohberg, P. Kann, G. Lübben, T. Konrad, S.D. Füllert, C. Sachara, A. Pfützner
Journal: Circulation (2005)

Patients with type 2 diabetes mellitus are at high risk of cardiovascular disease. Carotid intima-media thickness (IMT) is a strong predictor of myocardial infarction and stroke.We compared the effects of pioglitazone-based therapy (45 mg/d) and glimepiride-based treatment (2.7+/-1.6 mg/d) for 12 and 24 weeks on metabolic control (HbA1c), insulin resistance (homeostasis model assessment), and carotid IMT (B-mode ultrasonography) in a randomized controlled study in 173 orally treated patients with type 2 diabetes (66 women, 107 men; mean+/-SD age, 62.6+/-7.9 years; body mass index, 31.8+/-4.6 kg/m2; HbA1c, 7.5+/-0.9%). Treatment was generally well tolerated in both groups. Despite similar improvements in metabolic control (HbA1c) after 24 weeks (-0.8+/-0.9% [pioglitazone] versus -0.6+/-0.8% [glimepiride]; P=NS), carotid IMT was reduced only in the pioglitazone group after 12 weeks (-0.033+/-0.052 versus -0.002+/-0.047 mm [glimepiride]; P<0.01 between groups) and 24 weeks (-0.054+/-0.059 versus -0.011+/-0.058 mm [glimepiride]; P<0.005 between groups). Insulin resistance was also improved only in the pioglitazone group (homeostasis model assessment, -2.2+/-3.4 versus -0.3+/-3.3; P<0.0001 between groups). Reduction of IMT correlated with improvement in insulin resistance (r=0.29, P<0.0005) and was independent of improvement in glycemic control (r=0.03, P=0.68).We found a substantial regression of carotid IMT, independent of improved glycemic control, after 12 and 24 weeks of pioglitazone treatment. This finding may have important prognostic implications for patients with type 2 diabetes mellitus.
Home and allergic characteristics of children with asthma in seven U.S. urban communities and design of an environmental intervention: the Inner-City Asthma Study.
Authors: Ellen F Crain, Michelle Walter, George T O'Connor, Herman Mitchell, Rebecca S Gruchalla, Meyer Kattan, George S Malindzak, Paul Enright, Richard Evans, Wayne Morgan, James W Stout
Journal: Environmental Health Perspectives (2002)

Most published environmental remediation interventions have been directed at single allergens and have employed demanding strategies; few have been performed in the homes of inner-city children disproportionately burdened by asthma. Our objective was a) to describe the allergen sensitivities, environmental tobacco smoke (ETS) exposure, and home environmental characteristics of a national sample of inner-city children with moderate to severe asthma and b) to develop and implement a multifaceted, home-based comprehensive intervention to reduce home allergens and ETS, tailored to the specific sensitization and exposure profiles of those children. Allergen skin testing and a home evaluation were performed to determine the presence of ETS and factors known to be associated with increased indoor allergen levels. Based on published remediation techniques, a home environmental intervention, organized into modules, each addressing one of five specific allergen groups or ETS, was designed. Of 994 allergic children from seven U.S. urban communities, 937 successfully completed baseline interviews and home allergen surveys and were enrolled. More than 50% of children had positive skin tests to three or more allergen groups. Cockroaches were reported in 58% of homes, wall-to-wall carpeting in the child's bedroom in 55%, a smoker in 48%, mice or rats in 40%, and furry pets in 28%. More than 60% of enrolled families received four or more modules, and between 94% and 98% of all modules were completed. We conclude that most inner-city children with moderate to severe asthma are sensitized to multiple indoor allergens and that environmental factors known to be associated with asthma severity are commonly present in their homes. The intervention developed for the Inner-City Asthma Study employs accepted methods to address an array of allergens and ETS exposure while ensuring that the intervention is tailored to the specific sensitization profiles and home characteristics of these children.
Global efforts to control AIDS are "entirely inadequate"
Authors: Z. Kmietowicz
Journal: BMJ (2003)

Efforts to stem the world's AIDS epidemic are “entirely inadequate,” warned the United Nations this week as it released figures showing that the number of people who became infected with HIV and died from AIDS hit record levels this year.

An estimated 40 million people around the world, including 2.5 million children, are living with HIV, according to latest figures from …
Chemical Treatment of Skin Cancer
Authors: G. M. King
Journal: BMJ (1967)

MEDcJOURN 495 quite common with premedication and seda- tion techniques preceding local or regional anaesthesia.Having recently studied 10 routine dissections and carried out two special dissections, I am very aware that both large and small vessels are readily available for puncture where a needle may be inserted to block the inferior dental nerve.In consequence, I shall never give another inferior dental block injection without an aspirating syringe.It seems difficult to believe that this pro- gressive trismus in three or four days can be due to "organization of a band of fibrous tissue "-maybe it is hydrostasis, and aspira- tion under general anaesthesia in one of their patients might be very interesting.Several authors have described this com- plication,'" but the most fascinating article is that by John Campbell.'This is a careful account and discussion by an astute dentist of his own affliction: "At the end of the sixth week the first signs of remission came.. .I reacted philosophically to the inci- dent."Little wonder that Killey and Kay get so many of these cases-even John Campbell might have taken " the dreary road to the south."-Iam, etc.,
Invasive Carcinoma in Colorectal Adenomas: Multivariate Analysis of Patient and Adenoma Characteristics
Authors: G. Nusko, U. Mansmann, U. Partzsch, A. Altendorf-Hofmann, H. Groitl, C. Wittekind, C. Ell, E. G. Hahn
Journal: Endoscopy (1997)

The risk of invasive carcinoma developing in colorectal adenomas is influenced by a number of characteristics, relating both to the patients and to the adenomas, and by the composition of the sample analyzed. The aim of the present study was use a multivariate analysis to investigate the risk of invasive carcinoma in endoscopically and surgically removed adenomas.Between 1978 and 1993, more than 20,000 polyps were prospectively documented at the Erlangen Registry of Colorectal Polyps. A multivariate analysis of 11,188 adenomas detected at the first total colonoscopy was carried out in order to investigate the risks associated with size and site--both of which can be assessed by endoscopic inspection alone- and the extent to which these may be modified by other patient and adenoma characteristics, with an influence on the risk of invasive carcinoma in colorectal adenomas.The size of the adenoma proved to be the most important influencing factor. Invasive carcinoma was never found in 5027 small adenomas (< or = 5 mm). Adenomas in the right colon had a lower risk than those in the left colon or rectum. But with increasing adenoma size, the malignancy rate showed a right-sided shift, with a significant interactive effect of size and right-sided location. However, the risk determined by the size and site of the adenoma was significantly modified by a number of patient and adenoma characteristics, including histological type, presence of multiple adenomas, and patient age and sex.The risk of invasive carcinoma in colorectal adenomas can only be adequately described by a complex model of the interactive effects of patient and adenoma characteristics on the main factors of size and site.
Impact of a Multidisciplinary Continuous Quality Improvement Program on the Positive Surgical Margin Rate after Laparoscopic Radical Prostatectomy
Authors: Karim Touijer, Kentaro Kuroiwa, Andrew Vickers, Victor E. Reuter, Hedwig Hricak, Peter T. Scardino, Bertrand Guillonneau
Journal: European Urology (2006)
Nonsurgical Pain Relief
Authors: Rebecca Voelker
Journal: JAMA (1995)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
LEADERSHIP QUALITIES AND HEALTH RELATED BEHAVIORS: IS THERE A RELATIONSHIP?
Authors: Elizabeth A. Jackson, Preeti Iyer, Jean E. DuRussel-Weston, Caren S. Goldberg, Bruce Rogers, LaVaughn Palma-Davis, Susan Aaronson, Catherine M. Fitzgerald, Marc Zimmerman, Lindsey R. Mitchell, Roopa Gurm, Kim A. Eagle
Journal: Journal of the American College of Cardiology (2010)
1019-206 Reduced adverse event rates after transcatheter closure of patent foramen ovale when using the amplatzer-PFO™ compared to the CardioSeal™ device
Authors: Sherman G Sorensen, Peter J Casterella, Joseph B Muhlestein, Robert R Pearson, Benjamin D Horne, Laurie Raleigh, Jeffrey L Anderson, Donald L Lappe
Journal: Journal of the American College of Cardiology (2004)
Abstract 5208: Simultaneous color-coded imaging to distinguish colon cancer stem-like and non-stem cells in the same tumor
Authors: Atsushi Suetsugu, Mohamed K. Hassanein, Mashito Nagaki, Hisataka Moriwaki, Michael Bouvet, Abdool R. Moossa, Robert M. Hoffman
Journal: Cancer Research (2011)

Abstract In this study, CD44+ HCT-116 cells were considered as colon cancer stem-like cells (CSCs) and CD44− HCT-116 cells were considered colon non-cancer stem cells (NCSCs). CD44+ cells were isolated by magnetic bead sorting. CD44+ cells outgrew CD44− cells in vitro. GFP-CD44+ cells preferentially migrated from the center of the spheroids after co-culture with RFP-CD44− cells. GFP-CD44+ cells grew to a greater extent subcutaneously in nude mice, when compared to the CD44− cells. Equal numbers of GFP CSCs and the RFP NCSCs were mixed and co-injected in the spleen of nude mice where the cells metastasized to the liver. GFP CSCs were found in greater numbers compared to RFP NCSCs in the liver of nude mouse. GFP CSCs and RFP NCSCs were co-injected in the wall of the cecum. GFP CSCs were observed in metastases formed in the small intestine and colon wall, to a much greater extent than RFP-NCSC. Simultaneous color-coded imaging of CSCs and NCSCs in the present study has demonstrated two very different subsets of cells within the HCT-116 cell line with respect to tumor growth and metastasis. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 102nd Annual Meeting of the American Association for Cancer Research; 2011 Apr 2-6; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2011;71(8 Suppl):Abstract nr 5208. doi:10.1158/1538-7445.AM2011-5208