DEMEROL: A NEW SYNTHETIC ANALGETIC, SPASMOLYTIC, AND SEDATIVE AGENT. II. CLINICAL OBSERVATIONS
Authors: Paul H. Noth, Hans H. Hecht, Frederick F. Yonkman
Journal: Annals of Internal Medicine (1944)

Article1 July 1944DEMEROL: A NEW SYNTHETIC ANALGETIC, SPASMOLYTIC, AND SEDATIVE AGENT. II. CLINICAL OBSERVATIONSPAUL H. NOTH, M.D., M.S. (in Medicine), HANS H. HECHT, M.D., FREDERICK F. YONKMAN, M.D., PH.D.PAUL H. NOTH, M.D., M.S. (in Medicine)Search for more papers by this author, HANS H. HECHT, M.D.Search for more papers by this author, FREDERICK F. YONKMAN, M.D., PH.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-21-1-17 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe chemical composition and pharmacologic properties of demerol have been described in a separate communication.1The present report deals with clinical observations of the actions of this drug. Since 1939 a great number of clinical reports on demerol (variously called Dolantin, Dolantol, Alba, D-140, S-140) have appeared in the South American and European literature including observations on more than 2,000 cases. Only a few clinical studies, however, have been published in this country,2, 3, 4, 5, 6, 7including a series of papers by Himmelsbach and Andrews on tolerance and addiction liabilities in former morphine addicts.8, 9, 10We have...Bibliography1. YONKMANNOTHHECHT FFPHHH: Demerol, a new synthetic analgetic, spasmolytic and sedative agent. I. Pharmacological observations, ANN. INT. MED., 1944, xxi, 7-16. Google Scholar2. HECHTNOTHYONKMAN HHPHFF: Demerol, clinical observations, Jr. Am. Med. Assoc., 1943, cxxi, 1307. Google Scholar3. BATTERMAN RC: The clinical effectiveness and safety of a new synthetic analgesic drug, demerol, Arch. Int. Med., 1943, lxxi, 345. CrossrefGoogle Scholar4. 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ROJASBELBEY NJ: Hábito tóxico y dolantina, Semana med., 1941, ii, 616-618. Google Scholar43. SCHWARKE R: Addiction to dolantin, Deutsch. Ztschr. f. d. ges. gerichtl. Med., 1941, xxv, 17-23. Google Scholar44. Foreign Medical News, Jr. Am. Med. Assoc., 1942, cxix, 1518. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Detroit, Michigan*Received for publication July 10, 1943.From the Departments of Medicine and of Pharmacology and Therapeutics of Wayne University College of Medicine; the Medical Departments of Detroit Receiving Hospital, and the William J. Seymour Hospital, Eloise, Michigan.This interdepartmental study received the support of Dr. J. M. Hiebert of the Alba Pharmaceutical Division, Winthrop Chemical Company the A. Mendelson Memorial Fund, of Detroit. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byMeperidine: A Critical ReviewA New Compound for AnalgesiaIntoxikationenAsthma bronchialeTHE USE OF DEMEROL IN PATIENTS WITH BRONCHIAL ASTHMA*J. A. HERSCHFUS, M.D., A. SALOMON, M.D., M. S. SEGAL, M.D., F.A.C.P.PHARMACOLOGY OF DEMEROL AND ITS ANALOGUESClinical Appraisal of Demerol, Benadryl and PyribenzamineRecent Advances in Pharmacology 1 July 1944Volume 21, Issue 1Page: 17-34KeywordsDrug therapyDrugsHospital medicineMorphineOpioid addictionPharmacologySedatives ePublished: 1 December 2008 Issue Published: 1 July 1944 PDF downloadLoading ...