Malignant Melanoma with Delayed Metastatic Growths
Authors: Dwight L. Wilbur, Howard R. Hartman
Journal: Annals of Internal Medicine (1931)

Article1 August 1931Malignant Melanoma with Delayed Metastatic GrowthsDWIGHT L. WILBUR, M.D., HOWARD R. HARTMAN, M.D., F.A.C.P.DWIGHT L. WILBUR, M.D.Search for more papers by this author, HOWARD R. HARTMAN, M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-5-2-201 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptMalignant melanoma, frequently termed melanosarcoma or melano-epithelioma, is one of the most malignant tumors encountered in man. In some instances, however, the body seems to possess unusual resistance to metastasis from these tumors and it may be years after the appearance or removal of the primary growth before sudden, rapid and overwhelming metastasis occurs. This type of growth should, therefore, lend itself well to the study of the mechanisms of metastasis of tumors and bodily resistance to tumor growth, were it possible, with present knowledge, to approach such a study. The established observations of the delay in metastasis of these...Bibliography1. ARMSTRONG : Quoted by Pepper. Google Scholar2. COHNHEIM : Quoted by Pepper. Google Scholar3. COLEYHOUGUET WBJP: Melanotic cancer: with a report of 91 cases, Ann. Surg., 1916, lxiv, 206-241. CrossrefGoogle Scholar4. CORDESHORNER FCWD: Metastatic melanoma of both eyes: report of case, Jr. Am. Med. Assoc., 1930, xcv, 655-658. CrossrefGoogle Scholar5. DAWSON JW: The melanomata, their morphology and histogenesis; a study of cell origins and transformations with a critical discussion on aspects of tumor growth and a clinical review, Edinburgh Med. Jr., 1925, xxxii, 501-732. Google Scholar6. DOBBERTIN : Melanosarkom des Kleinhirns und Rückenmarks, Beitr. z. path. Anat. u. z. allg. Path., 1900, xxviii, 52-56. Google Scholar7. EWING J: The problems of melanoma, Brit. Med. Jr., 1930, ii, 852-856. CrossrefGoogle Scholar8. FISHERBOX HCR: Pigmented tumour of the eyeball: death from multiple pigmented carcinoma nearly fourteen years after excision of the eye, Brit. Med. Jr., 1900, i, 639-640. Google Scholar9. HANDLEY WS: The pathology of melanotic growths in relation to their operative treatment, Lancet, 1907, i, 927-933; 996-1003. Google Scholar10. HUTCHINSON J: Quoted by Schroeder. Google Scholar11. LAUROBAUGH : Quoted by Schroeder. Google Scholar12. LILLEY CH: Quoted by Schroeder. Google Scholar13. MASSON : Quoted by Ewing. Google Scholar14. MAXWELL W: Secondary melanomata of small intestine with chronic intestinal obstruction and intussusception, Med. Jr. Australia, 1928, ii, 656-657. CrossrefGoogle Scholar15. MCWHORTERCLOUD JEAW: Malignant tumors and their metastases, Ann. Surg., 1930, xcii, 434-443. CrossrefGoogle Scholar16. OERTEL H: Outlines of pathology in its historical, philosophical, and scientific foundations, 1927, Ed. 1, Montreal, Renouf Publishing Co., 479 pp. Google Scholar17. OERTEL H: Quoted by Pepper. Google Scholar18. PEPPER OH: Metastasis, Internat. Clin., 1924, ii, 269-286. Google Scholar19. SAPHIR O: Metastatic melanoma of the jejunum: report of a case, Arch. Path. and Lab. Med., 1927, iv, 22-25. Google Scholar20. SCHROEDER MJ: Late metastasis of melanosarcoma of the liver, Med. Jr. and Rec., 1924, cxix, 601-603. Google Scholar21. STACYVANZANT LJFR: Poisoning from cinchophen. Minnesota Med., 1930, xiii, 327-328. Google Scholar22. SYMMERS : Quoted by Pepper. Google Scholar23. WILDER WH: Quoted by Schroeder. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Division of Medicine The Mayo Clinic Rochester, Minnesota*Submitted for publication February 20, 1931. 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