Nasal Carriage of Staphylococcal Infection in Wegener Granulomatosis
Authors: Carl Lawyer
Journal: Annals of Internal Medicine (1994)

Letters1 July 1994Nasal Carriage of Staphylococcal Infection in Wegener GranulomatosisCarl Lawyer, MD, Joseph Henkle, MD, and Haitham Bakir, MDCarl Lawyer, MDSouthern Illinois University School of Medicine; Springfield, IL 62794Search for more papers by this author, Joseph Henkle, MDSouthern Illinois University School of Medicine; Springfield, IL 62794Search for more papers by this author, and Haitham Bakir, MDSouthern Illinois University School of Medicine; Springfield, IL 62794Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-121-1-199407010-00023 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:Stegeman and colleagues [1] reported the association of chronic nasal carriage of Staphylococcus aureus with higher relapse rates in Wegener granulomatosis and discussed the possibility of its causal role in autoimmune phenomena. The c-antineutrophil cytoplasmic antibody (c-ANCA) Wegener granulomatosis autoantigen is a serine protease with strong similarity to other trypsin-family serine proteases. It is homologous in its first 100 amino acids (with >50% identity) to granzyme B (a killer-cell-specific serine protease also known as cytotoxic T-lymphocyte proteinase-2, whose expression may be involved in the acute rejection of renal allografts and in apoptosis. This area of near identity ...References1. Stegeman CA, Cohen Tervaert JW, Sluiter WJ, Manson WL, de Jong PE, Kallenberg CG. Association of chronic nasal carriage of Staphylococcus aureus and higher relapse rates in Wegener granulomatosis. Ann Intern Med. 1994; 120:12-7. Google Scholar2. Caputo A, Fahey D, Lloyd C, Vozab R, McCairns E, Rowe PB. Structure and differential mechanisms of regulation of expression of a serine esterase gene in activated human T lymphocytes. J Biol Chem. 1988; 263:6363-9. Google Scholar3. Dancer SJ, Garratt R, Saldanha J, Jhoti H, Evans R. The epidermolytic toxins are serine proteases. FEBS Lett. 1990; 268:129-32. Google Scholar4. Bailey CJ, Smith TP. The reactive serine residue of epidermolytic toxin A. Biochem J. 1990; 269:535-7. Google Scholar Author, Article, and Disclosure InformationAuthors: Carl Lawyer, MD; Joseph Henkle, MD; Haitham Bakir, MDAffiliations: Southern Illinois University School of Medicine; Springfield, IL 62794 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byCase of Nocardia Cyriacigeorgica Infection of the Eye in a Granulomatosis With Polyangiitis PatientProteinase 3-ANCA Vasculitis versus Myeloperoxidase-ANCA VasculitisMucor irregularis Infection and Lethal Midline Granuloma: A Case Report and Review of Published LiteratureAsbestos Exposure and Antineutrophil Cytoplasmic Antibody (ANCA) PositivityDiagnostic and pathogenetic role of antineutrophil cytoplasmic autoantibodiesStaphylococcus aureus, répertoire lymphocytaire T et granulomatose de WegenerStaphylococcus aureus, T-cell repertoire, and Wegener’s granulomatosisANTINEUTROPHIL CYTOPLASMIC AUTOANTIBODY TESTING IN VASCULITIDESAntineutrophil cytoplasmic autoantibodies, autoantigens, and systemic vasculitis 1 July 1994Volume 121, Issue 1Page: 74-75KeywordsAntigensAutoantigenEnterotoxinsProteasesProteinsSerine proteasesStaphylococcal infectionStaphylococcus aureusToxinsWegener granulomatosis ePublished: 15 August 2000 Issue Published: 1 July 1994 Copyright & PermissionsCopyright © 1994 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...