THE THERAPEUTIC EFFECT OF SOLUTION OF POTASSIUM ARSENITE IN CHRONIC MYELOGENOUS LEUKEMIA
Authors: D. J. Stephens, John S. Lawrence
Journal: Annals of Internal Medicine (1936)

Article1 May 1936THE THERAPEUTIC EFFECT OF SOLUTION OF POTASSIUM ARSENITE IN CHRONIC MYELOGENOUS LEUKEMIAD. J. STEPHENS, M.D., JOHN S. LAWRENCE, M.D.D. J. STEPHENS, M.D.Search for more papers by this author, JOHN S. LAWRENCE, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-9-11-1488 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptFor many years roentgen therapy has been the most satisfactory method of treatment of the chronic leukemias. It is generally agreed that life is not materially prolonged by irradiation, but in favorable cases symptomatic and hematologic improvement occurs for variable periods of time. Some patients experience uncomfortable reactions to treatment, others become refractory to irradiation, and occasionally an alarming depression of the red and white blood cells occurs. In the absence of specific forms of therapy for the disease, there is need of other palliative measures which may be used in place of, or in conjunction with, roentgen therapy. Interest...References1. FORKNERSCOTT CETF: Arsenic as a therapeutic agent in chronic myelogenous leukemia, Jr. Am. Med. Assoc., 1931, iii, 97. Google Scholar2. FORKNER CE: The administration of solution of potassium arsenite in the treatment of chronic myelogenous leukemia, Med. Clin. N. Am., 1932, xv, 1057. Google Scholar3. FRETWORSTHORWITZROSENBAUM FSR: Zur Frage der Arsenwasserstoffvergiftung mit besonderer Berücksichtigung der Blutveränderungen, Ztschr. f. klin. Med., 1933, cxxiii, 703. Google Scholar4. WICHELSHOFER I: Arsen und Blutbildung, Klin. Wchnschr., 1933, xii, 591. CrossrefGoogle Scholar5. ISAACS R: The effect of arsenic on the maturation of red blood cells, Folia haemat., 1928, xxxvii, 389. Google Scholar6. MCALPINGOLDENEDSALL KRRKS: The roentgen treatment of chronic leukemia, Am. Jr. Roentgen., 1931, xxvi, 47. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Rochester, New York*Received for publication January 31, 1936.From the Department of Medicine, School of Medicine and Dentistry, University of Rochester, and the Medical Clinic of the Strong Memorial and Rochester Municipal Hospitals, Rochester, New York. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byCurrent status and future prospects of nanomedicine for arsenic trioxide delivery to solid tumorsArsenical-based cancer drugsArsenic trioxide in the treatment of haematological malignanciesThe potential of arsenic trioxide in the treatment of malignant disease: past, present, and futureEffects of arsenic trioxide (As 2 O 3 ) on leukemic cells from patients with non-M3 acute myelogenous leukemia: studies of cytotoxicity, apoptosis and the pattern of resistanceDelicious Poison: Arsenic Trioxide for the Treatment of LeukemiaTREATMENT OF CHRONIC MYELOID LEUKÆMIAErgebnisse der Leukoseforschung der letzten JahreÜbersicht über die Leukoseforschung der Letzten Jahre 1 May 1936Volume 9, Issue 11Page: 1488-1502KeywordsChronic myelogenous leukemiaDentistryHospital medicineLeukemiaPalliative carePotassiumWhite blood cells Issue Published: 1 May 1936 PDF downloadLoading ...