tbuckley/cabot-search huggingface dataset:
Abstract B06: Development of novel thiobarbituric acid derivative compounds for treatment of lung cancers.
Authors: Sang Y. Lee, Srinivasa Ramisetti, Becky Slagle-Webb, Arun K. Sharma, James R. Connor
Journal: Clinical Cancer Research (2014)

Abstract Previously, we reported the identification of a cytotoxic chemotype compound CC-I (a derivative of thiobarbituric acid) that is effective against chemotherapy resistant glioblastomas (GBMs) and neuroblastoma in an in vitro cell culture and in vivo mouse tumor models. In this study, we determined the cytotoxicity of CC-I and structurally similar compounds along in lung cancers to determine whether CC-I is toxic to lung cancers and to identify additional analog compounds that could be more toxic than CC-I. We designed several CC-I analog compounds by manipulating functional substitutions at N1-, N3- and C5-positions (either furan ring or benzene ring) of CC-I. For example, the novel compounds were synthesized starting from substituted thioureas, key precursors for the synthesis of substituted thiobarbituric acids, and finally by condensing cinnamaldehyde (CMC-2 series: benzene ring compound) or trans-3-(2-furyl)-acrolein (CC-I series: furan ring compound) with appropriately substituted thiobarbituric acids in the presence of catalytic amounts of pyridine. We used MTS cell proliferation or SRB cytotoxicity assay to determine the toxic level of compounds on the human lung cancer cell lines (e.g., A549, H520, H460, H69). The data suggest that the functional group at N1-, N3- and C5 sites is important for toxicity. Among the compounds with similar structures, CC-I-v3 and CC-I-v4 are the two most cytotoxic compounds to lung cancer cells and also the cisplatin resistant lung cancer cell lines such as H1993 and H520. In some of the cell lines we investigated, CC-I-v1 and CMC-2 compounds showed greater toxicity than CC-I compound. Currently, we are studying the anti-tumor effect of these compounds in an in vivo nude mouse tumor model. In summary, this structure-activity study clearly indicates that we can develop more efficacious compounds compared to our original compounds by rational modifications of the chemotype compounds. [This project is supported by the Elsa U. Pardee Foundation] Citation Format: Sang Y. Lee, Srinivasa Ramisetti, Becky Slagle-Webb, Arun K. Sharma, James R. Connor. Development of novel thiobarbituric acid derivative compounds for treatment of lung cancers. [abstract]. In: Proceedings of the AACR-IASLC Joint Conference on Molecular Origins of Lung Cancer; 2014 Jan 6-9; San Diego, CA. Philadelphia (PA): AACR; Clin Cancer Res 2014;20(2Suppl):Abstract nr B06.
Can we really leave gender out of it? Individual differences and the Simulation of Smiles model
Authors: Elizabeth Simpson, Dorothy Fragaszy
Journal: Behavioral and Brain Sciences (2010)

Abstract Gender differences in face-based emotion recognition, notably differential use of mimicry, may compromise the extent to which the Simulation of Smiles (SIMS) model can be generalized to populations besides the adult females on which it has been tested. Much work indicates sex differences in face-based emotion recognition, including smile recognition.
Rectal IgE cells in inflammatory bowel disease.
Authors: D P O'Donoghue, P Kumar
Journal: Gut (1979)

Immunoglobulin-contained cells in the rectal mucosa of patients suffering from non-specific inflammatory bowel disease (IBD) were counted and compared with those in a control population. While the numbers of IgA, IgM, and IgG-containing cells in both ulcerative colitis and Crohn's disease did not differ from normal, both disease groups exhibited a marked increase in IgE-staining cells. This increase in IgE-cells did not correlate with severity, duration, or treatment of disease and it did not prove possible, using these immunological studies, to differentiate between Crohn's disease and ulcerative colitis.
An alternative anterior tension free preperitoneal patch technique by help of the endoscope for femoral hernia repair
Authors: Fahri Yetişir, A. Ebru Salman, Onur Özlü, Mehmet Kiliç
Journal: International Journal of Surgery (2013)

Femoral hernias are relatively uncommon and have a higher risk for strangulation and incarceration. We introduce an alternative anterior tension free inlay patch technique by help of the endoscope for femoral hernia repair. Characteristics of patients undergoing femoral hernia repair between March 2006–April 2011 and description of the surgical technique is presented. We analyzed our experience with this technique in 26 consecutive patients with femoral hernias (1 bilateral, 15 right, 10 left femoral hernia) in 5 year period. Seven of these 26 femoral hernias were recurrent and 2 of them were concomitant with inguinal hernia. Mean operation time was 30.0 ± 12.1 min. Seroma was seen in 2 patients at postoperative 1st week. There were no; hematoma, wound infection and separation of wound edges and early recurrence at postoperative 1st week and 1st month. The mean follow up period was 41.8 ± 18.2 months. All of 22 patients who were contacted were satisfied with the operation. There was no recurrence, chronic pain and foreign body feeling in any patient at the end of the follow-up period. This feasible and safe alternative anterior inlay patch repair might be used in all femoral hernias with the exception of the ones requiring intestinal resection.
Underuse of evidence-based medicine and outcome of acute myocardialinfarction patients with renal failure
Authors: Ariel Tessone, Israel M. Barbash, Shmuel Gottlieb, Alexander Battler, Yonathan Hasin, Valentina Boyko, Avi Porat, Solomon Behar, Jonathan Leer
Journal: Journal of the American College of Cardiology (2002)
ADDENBROOKE'S HOSPITAL, CAMBRIDGE. CASES OF STRICTURE, IN WHICH SYME'S OPERATION WAS PERFORMED
Authors: G. M. Humphry
Journal: BMJ (1856)

C.snc i. Wm.Buck, aged 55, a strong healthy man, was received into the hospital on the morning of April 22nd, 1855, in extreme agony from retention of urine.Nearly forty years previously, he fell across a plank upon his perinisum.He was then admitted into the hospital; and Mr. Okes found it necessary to cut into the perineum, for the purpose of emptying the bladder.He had experienced difficulty in making water ever since.In April 1846, I opened his bladder from the perinseum, in consequence of
Physician Specialty Society Clinical Guidelines and Bending the Cost Curve Comment on “Cost Consideration in the Clinical Guidance Documents of Physician Specialty Societies in the United States”
Authors: Joseph P. Drozda
Journal: JAMA Internal Medicine (2013)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Internal Medicine HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Internal Medicine journal
Prescribing of antibiotics and admissions for respiratory tract infections in England
Authors: Azeem Majeed, Susan Williams, Brian Jarman, Paul Aylin
Journal: BMJ (2004)

The increase in antibiotic resistance is one of the most worrying trends facing 21st century medicine. Much antibiotic prescribing is of little therapeutic value, and lower prescribing rates may lead to lower rates of resistance.w1 Consequently, doctors are being encouraged to use antibiotics less frequently. However, lower levels of antibiotic prescribing may lead to an increase in complications from infectious diseases.w2 We analysed NHS primary care prescribing data in England to examine the number of antibiotic prescriptions per 1000 population (STAR-PU weighted) between 1996 and 2002, as well as the standardised hospital admission rate for respiratory tract infections during the same period. 

#### The bottom line

• A sustained decrease in community antibiotic prescribing rates in recent years has been associated …
The ubiquitin‐proteasome pathway and proteasome inhibitors
Authors: Jayhyuk Myung, Kyung Bo Kim, Craig M. Crews
Journal: Medicinal Research Reviews (2001)

Abstract The ubiquitin‐proteasome pathway has emerged as a central player in the regulation of several diverse cellular processes. Here, we describe the important components of this complex biochemical machinery as well as several important cellular substrates targeted by this pathway and examples of human diseases resulting from defects in various components of the ubiquitin‐proteasome pathway. In addition, this review covers the chemistry of synthetic and natural proteasome inhibitors, emphasizing their mode of actions toward the 20S proteasome. Given the importance of proteasome‐mediated protein degradation in various intracellular processes, inhibitors of this pathway will continue to serve as both molecular probes of major cellular networks as well as potential therapeutic agents for various human diseases. © 2001 John Wiley &amp; Sons, Inc. Med Res Rev, 21, No. 4, 245–273, 2001
Flufenamic acid in rheumatoid arthritis.
Authors: K T Rajan, A G Hill, A Barr, E Whitwell
Journal: Annals of the Rheumatic Diseases (1967)

This is a report of a clinical trial comparing the effects in patients with rheumatoid arthritis of an anti-inflammatory drug, flufenamic acid, with the familiar anti-rheumatic drugs phenylbutazone and soluble aspirin.Flufenamic acid, N-(aaa-trifluoro-m-tolyl) an- thranilic acid, is a stable, weak carboxylic acid with the formula shown in Fig. 1.COOH
Effects of aspirin and clopidogrel on plasma brain natriuretic peptide in patients with heart failure receiving ACE inhibitors
Authors: Christophe Meune, Karim Wahbi, Yvonne Fulla, Alain Cohen‐Solal, Denis Duboc, Isabelle Mahé, Guy Simoneau, Jean‐François Bergmann, Simon Weber, Stéphane Mouly
Journal: European Journal of Heart Failure (2006)
Equity, poverty and health for all
Authors: K. C Calman
Journal: BMJ (1997)

The concept of “health for all” provides a vision of what might be achieved if the potential for improving health is realised. It is about having a life with meaning–one that is particularly relevant when poverty is discussed. Many of the issues that really matter in improving the public's health come under this heading. They include the emphasis on health, the importance of equity, the relevance of partnerships, and the need to involve patients and the public in health.

The WHO was not the first to use the slogan Health For All. In 1941, Julian Huxley, in Picture Post , a weekly British magazine, wrote a prophetic article entitled “Health For All.” In it he called for “a healthy diet for all, everyone to have a chance to reach known health standards, public health as a positive service, health put on a family basis, a real family and population policy, and child welfare centres started everywhere.” The National Health Service in the United Kingdom, set up in 1948, embodied many of these principles.

The WHO Health for All initiative began in Almaty, Kazakstan, in 1978 with a declaration that emphasised the importance of equity, economic and social development, and of participation by the people in the process of improving health–and the crucial role of primary care. It encouraged each country to formulate national policies and strategies for health. To those who were around at the time it was a period of great vision and aspirations. The regions of the WHO took up the challenge, and in 1984 the European region launched the 38 targets for the region as a whole. The WHO is in the process of revitalising the strategy–a revised version will be completed by 1998. Around the world new ideas are being considered which will take Health for …
Expression of 11β-hydroxysteroid dehydrogenase 1 and 2 in patients with chronic rhinosinusitis and their possible contribution to local glucocorticoid activation in sinus mucosa
Authors: Young Joon Jun, Se Jin Park, Tae Hoon Kim, Seung Hoon Lee, Ki Jeong Lee, Soo Min Hwang, Sang Hag Lee
Journal: Journal of Allergy and Clinical Immunology (2014)
Association of Urinary Inflammatory Markers and Renal Decline in Microalbuminuric Type 1 Diabetics
Authors: Pawel P. Wolkow, Monika A. Niewczas, Bruce Perkins, Linda H. Ficociello, Boguslaw Lipinski, James H. Warram, Andrzej S. Krolewski
Journal: Journal of the American Society of Nephrology (2008)

Progressive renal function decline begins in one third of patients with microalbuminuria and type 1 diabetes. This study examined whether this decline is associated with elevated excretion of inflammatory markers in urine. Five inflammatory markers (IL-6, IL-8, monocyte chemoattractant protein-1, interferon-gamma-inducible protein (IP-10), and macrophage inflammatory protein-1delta) were measured in urine samples from the First Joslin Study of the Natural History of Microalbuminuria in Type 1 Diabetes, a cohort recruited in 1991. Samples were obtained from 43 participants with microalbuminuria and stable renal function (nondecliners), from 28 with microalbuminuria and early progressive renal function decline (decliners), and from 74 with normoalbuminuria and stable renal function (reference). Urinary concentrations of all five inflammatory markers were significantly higher in decliners than in nondecliners, who were similar to the reference group. Multivariate analysis revealed that those with more than two markers elevated were more than five times as likely to have early progressive decline of renal function. In contrast, serum concentrations of C-reactive protein, IL-8, and macrophage inflammatory protein-1delta did not differ between decliners and nondecliners. These results support the hypothesis that inflammatory processes in the kidney contribute to the progression of nephropathy in patients with type 1 diabetes.
Cytomegalovirus-induced Gingivitis
Authors: Joel B. Epstein, Christopher H. Sherlock, Robert A. Wolber
Journal: Annals of Internal Medicine (1992)

Letters15 June 1992Cytomegalovirus-induced GingivitisJoel B. Epstein, DMD, MSD, Christopher H. Sherlock, MD, Robert A. Wolber, MDJoel B. Epstein, DMD, MSD, Christopher H. Sherlock, MD, Robert A. Wolber, MDAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-116-12-1034_1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the Editors: Oral disease frequently develops in immunosuppressed patients, and cytomegalovirus contributes to this by producing mucosal ulcers as it does elsewhere in the alimentary tract. We describe here the first reported case of cytomegalovirus gingivitis that resulted in symptomatic hyperplasia rather than in ulceration.A 35-year-old cytomegalovirus-seronegative man received a heart transplant on 9 November 1989, from a cytomegalovirus-seropositive donor. He was immunosuppressed with cyclosporine A, azathioprine, and prednisone. In December, he developed gum enlargement and tenderness. On February 26, when a biopsy was done, his gingiva were markedly enlarged, firm, and pink, extending to the incisa edges...References1. RobsonMackay GI. Generalized cytomegalovirus infection in a patient with lupoid hepatitis. Aus Ann Med. 1969;18:147-50. CrossrefMedlineGoogle Scholar2. WilliamsStrettonLeonard GTJ. Cytomegalic inclusion disease and Pneumocystis carinii infection in an adult. Lancet. 1960;2:951-5. CrossrefMedlineGoogle Scholar3. MyersonHackmanNelsonWardMcDougall DRJDJ. Widespread evidence of histologically occult cytomegalovirus. Hum Pathol. 1984;15:430-9. CrossrefMedlineGoogle Scholar4. KanasJensenAbrams RJA. Cytomegalovirus infection with acute erosive esophagitis. Am J Med. 1984;76:924-8. CrossrefMedlineGoogle Scholar5. LangfordKunzeTimmRufReichart ARHBP. Cytomegalovirus associated oral ulcerations in HIV-infected patients. J Oral Pathol Med. 1990;19:71-6. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByInfectious and tropical diseases affecting the human mouthMammalian viruses in human periodontitisNew Aspects of Oral Viral DiseasesCytomegalovirus (CMV) and Helicobacter pylori(HP) found in oral mucosal ulcersCytomegalovirus: a virus of increasing relevance to oral medicine and pathologyOral manifestations of cytomegalovirus infection 15 June 1992Volume 116, Issue 12_Part_1Page: 1034-1034KeywordsBiopsyHeartOral diseasesUlcers Issue Published: 15 June 1992 PDF DownloadLoading ...
Acute Hemodynamic Effects of Dopamine in Patients with Shock
Authors: HENRY S. LOEB, EDWARD B. J. WINSLOW, SHAHBUDIN H. RAHIMTOOLA, KENNETH M. ROSEN, ROLF M. GUNNAR
Journal: Circulation (1971)

The hemodynamic effects of dopamine were studied in 62 patients with clinical shock. In 36 patients with infection dopamine increased mean arterial pressure (MAP) 30%, and cardiac output (CO) 37%. Urine flow (UF) increased from 0.5 ml/min to 1.6 ml/min. Norepinephrine (NE) in 26 patients resulted in a higher MAP, lower CO, and similar UF. Isoproterenol (Isp) in 19 patients resulted in a lower MAP, higher CO, and a significantly lower UF. In 13 patients with cardiogenic shock dopamine increased MAP 6%, and CO 40%. UF increased from 0.6 ml/min to 1.1 ml/min. NE in eight patients resulted in a lower CO than during dopamine infusion, and Isp in five patients resulted in a higher CO. Dopamine improves MAP pressure, CO, and UF when shock is due to infection and is superior to Isp which does not increase perfusion pressure to adequate levels and does not improve UF. In patients with cardiogenic shock who have reduced CO and increased systemic vascular resistance, perfusion pressure tended to be adequate, and improved CO occurred with dopamine and Isp but not with NE. Although Isp increased CO more than dopamine, differences in regional perfusion are important in selection of the best inotropic agent and in most patients make dopamine the preferred agent.
Prognostic factors for therapeutic outcome of diffuse small non‐cleaved cell lymphoma in adults
Authors: Vicki A. Morrison, Glauco Frizzera, Diane C. Arthur, Kathleen M. Ogle, David D. Hurd, Clara D. Bloomfield, Bruce A. Peterson
Journal: American Journal of Hematology (1994)

Abstract Most reports of prognosis and therapy in diffuse small non‐cleaved cell lymphoma (DSNCL), an aggressive high‐grade non‐Hodgkin's lymphoma (NHL) which appears to be of two histopathologic subtypes, have included predominantly a pediatric population and very few adults. We studied 20 newly diagnosed, previously untreated adults with DSNCL. Three patients had Ann Arbor Stage I disease, five Stage II, and 12 Stage IV. Bone marrow involvement was present in seven of 20 (35%) patients; no patient had central nervous system involvement at diagnosis. Clonal chromosomal abnormalities were found on cytogenetic analysis of all 12 cases studied. Ten patients had specific recurring translocations, including t(8;14) (q23;q32) (five patients), t(14;18) (q32;q21) (four patients), and t(2;8) (p12;q24) (one patient). Induction chemotherapy with the COMP regimen (cyclophosphamide, vincristine, methotrexate, and prednisone) or a variant schedule of the same drugs resulted in complete remission for 13 patients (65%), and partial remission for 5 patients (25%). Clinical characteristics predictive of a favorable response to induction therapy included Stage I or II disease, a normal lactic dehydrogenase (LDH), and performance status (PS) of 0 or 1. Remission duration ranged from two to 125+ (median 37+) months. Survival ranged from one to 126+ (median 23) months; ten patients (50%) remain alive, nine with no active disease. Factors predictive of longer survival included achievement of a complete remission with induction therapy, a normal LDH, and PS 0 or 1. As in children with DSNCL, long‐term disease‐free survival may be achieved in adults with combination chemotherapy. © 1994 Wiley‐Liss, Inc.
Inhibition of secretin stimulated pancreatic secretion by pancreatic polypeptide.
Authors: T E Adrian, H S Besterman, C N Mallinson, G R Greenberg, S R Bloom
Journal: Gut (1979)

The effect of PP on secretin-stimulated pancreatic secretion was assessed in five healthy subjects. During an intravenous infusion of BPP at a dose which produced plasma levels similar to those seen after meals in healthy young adults the volume and bicarbonate content of duodenal juice was reduced by 25% (p less than 0.05) and 24% (p less than 0.05) respectively, while protein and bilirubin concentrations were more markedly reduced by 68% (p less than 0.0005) and 67% (p less than 0.0005) respectively. PP, thus, may be an important inhibitory factor in the control of bilirubin and pancreatic enzyme secretion in man.
Membranous glomerulonephritis in rheumatoid arthritis unassociated with gold or penicillamine treatment.
Authors: A Higuchi, Y Suzuki, T Okada
Journal: Annals of the Rheumatic Diseases (1987)

A 16 year old girl with rheumatoid arthritis who had not received gold or penicillamine developed a nephrotic syndrome. Her renal biopsy specimen showed membranous glomerulonephritis by light, electron, and immunofluorescence microscopy.
972-106 Intramural Activation Patterns of Focal Ventricular Tachycardia Induced by Programmed Stimulation During Experimental Subacute Myocardial Infarction
Authors: Guanglie Wu, laszlo Littmann, Robert H. Svenson, George P. Tatsis, Glenn A. Nanney, Jan R. Tuntelder, Michelle Thompson, Kathy R. Dezern
Journal: Journal of the American College of Cardiology (1995)