Rheumatoid Arthritis-like Disease after Alpha-Interferon Therapy
Authors: Pascal Chazerain, Olivier Meyer, Marcel-Francis Kahn
Journal: Annals of Internal Medicine (1992)

Letters1 March 1992Rheumatoid Arthritis-like Disease after Alpha-Interferon TherapyPascal Chazerain, MD, Olivier Meyer, MD, Marcel-Francis Kahn, MDPascal Chazerain, MD, Olivier Meyer, MD, Marcel-Francis Kahn, MDAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-116-5-427_1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the Editors: We read with great interest the article by Ronnblom and colleagues (1) describing the development of autoimmune diseases after alpha-interferon therapy for malignant carcinoid tumors. We extend the scope of alpha-interferon-induced autoimmune diseases by reporting the cases of three patients with rheumatoid arthritis-like disease.Two men and one woman (64, 52, and 42 years of age, respectively) with chronic myeloproliferative disorders (two patients) and chronic active autoimmune hepatitis (one patient) developed symptoms and signs consistent with acute (one patient) or chronic (two patients) polyarthritis during treatment with recombinant alpha-interferon (alpha-2a, Roferon, Roche, Nutley, New Jersey; or alpha-2b,...References1. RonnblomAlmOberg LGK. Autoimmunity after alpha-interferon therapy for malignant carcinoid tumors. Ann Intern Med. 1991;115:178-83. LinkGoogle Scholar2. RondeauSolal-CelignyDhermBoivin EPYP. Immune disorders in a gnogenic myeloid metaplasia: relations to myelofibrosis. Br J Haematol. 1983;53:467-75. CrossrefMedlineGoogle Scholar3. ConlonUrbaSmithSteisLongoClark KWJRDJ. Exacerbation of symptoms of autoimmune disease in patients receiving alpha-interferon therapy. Cancer. 1990;65:2237-42. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: Pascal Chazerain, MD; Olivier Meyer, MD; Marcel-Francis Kahn, MDAffiliations: Xavier Bichet Medical School 75018 Paris France PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byArthritis Induced by Interferon-alpha Therapy in a Patient with Essential ThrombocythemiaArthritis during interferon beta-1b treatment in multiple sclerosisThe Neutralization of Type I IFN Biologic Actions by Anti-IFNAR-2 Monoclonal Antibodies Is Not Entirely Due to Inhibition of Jak-Stat Tyrosine PhosphorylationStat4 Is Expressed in Activated Peripheral Blood Monocytes, Dendritic Cells, and Macrophages at Sites of Th1-Mediated InflammationParaneoplastic rheumatic syndromesImmunotoxicology—Regulatory and Risk Assessment ConceptsDermatomyositis after interferon alpha treatmentAutoimmunity and risk assessment.Infection par le virus de l'hépatite C et pathologies thyroïdiennesInterferon-?1A-induced polyarthritis in a patient with the HLA-DRB1*0404 alleleAlpha-interferon-induced arthritis: clinical presentation, treatment, and preventionAnti-cytokine autoantibodies: Epiphenomenon or critical modulators of cytokine actionAdverse Effects of Interferon TreatmentAnti-cytokine autoantibodies: Epiphenomenon or critical modulators of cytokine actionPsoriatic Arthritis with Spinal Involvement in a Patient Receiving Alpha-interferon for Chronic Hepatitis CDevelopment of Sjögren's syndrome during treatment with recombinant human interferon-alpha-2b for chronic hepatitis CInterferon-α for Viral HepatitisHepatitis C virus infection: clinical aspects and treatment with interferon alfaRegulation of early complement components C3 and C4 in the synoviumImmunological Adverse Effects of Interferon TreatmentInterferons for viral hepatitisDrugs Recently Associated With Lupus SyndromesAcquired factor VIII inhibitor associated with chronic interferon-alpha therapy in a patient with haemophilia AHuman leucocyte interferon-α therapy can induce a second response in treatment of thrombocytosis in patients with neutralising antibodies to recombinant interferon-α2aHypothyroidism and arthritis during interferon therapyMaladies auto-immunes et traitement par l'IFN-α: revue de la littérature à propos d'un cas d'hyperthyroïdieRheumatic disease following immunotherapy.Cytostatics and immunosuppressive drugsAlpha-Interferon-induced Nodular Rheumatoid Arthritis in Renal Cell CarcinomaYukio Ueno, MD, Takaomi Sohma, MDInterferon alpha 1 March 1992Volume 116, Issue 5Page: 427-427KeywordsArthritisAutoimmune diseasesAutoimmune hepatitisCarcinoid tumorMalignant tumorsMyeloproliferative disordersPatientsSigns and symptoms ePublished: 1 December 2008 Issue Published: 1 March 1992 PDF downloadLoading ...