tbuckley/cabot-search huggingface dataset:
THU0483 Arterial Aneurysms in Behcet’s Disease. A Report of 25 Cases
Authors: T. Ben Salem, H. Tounsi, A. Hamzaoui, N. Belfeki, M. Khanfir-Smiti, M. Lamloum, I. Ben Ghorbel, M. H. Houman
Journal: Annals of the Rheumatic Diseases (2013)

<h3>Background</h3> Arterial involvements occur in less than 10 % of patients with Behçet's disease (BD). Aneurysms are the most frequent lesions and constitute one of the mortality's causes. <h3>Objectives</h3> The aim of this study was to evaluate prevalence of aneurysms in BD in Tunisian patients and to describe clinical features, treatment and outcome of patients having this involvement. <h3>Methods</h3> A retrospective study was made. Files of patients followed for BD (criteria of the International Study Group of BD) in our internal medicine department were studied. Patients having arterial aneurysms were included. Aneurysm diagnosis was confirmed, according to his location, using cerebral, thoracic or abdominal scanography, coronarography or doppler ultrasound. <h3>Results</h3> Among 488 patients with BD, 25 had arterial aneurysms (5.1%). There were 23 men and 2 women. The mean age at the disease onset was 29 +/- 10.28 years, and was 33.84 +/- 10.14 years at BD diagnosis. Aneurysm revealed BD in 12 cases (2.4%). Abdominal aorta aneurysm was the most frequent (8 cases). Aneurysms in pulmonary arteries were confirmed in 7 cases and superficial femoral artery was involved in 2 patients. Other locations as primitive carotid artery, humeral artery, hypogastric artery, internal iliac artery, communal femoral artery, deep femoral artery, poplit artery and posterior tibial artery were noted each in only one case. Two patients underwent a myocardial infarction due to coronial artery aneurysm. Two patients had 2 different locations. All patients were symptomatic (abdominal pain, thoracic pain, limbs pain, gastrointestinal bleeding or haemoptysis). Comparison between patients with and without aneurysm showed that ocular involvement and HLA B51 were significantly less frequent in patients having aneurysm whereas deep venous thrombosis were significantly more frequent in these patients. All patients were treated by corticosteroids, 10 patients had surgery associated to immunosuppressive therapy (8 patients). The other patients had only immunosuppressive therapy. Only 2 patients had relapse. One patient died because of aneurysm rupture before any treatment. <h3>Conclusions</h3> Arterial aneurysms are uncommon in BD. They were significantly associated to deep venous thrombosis. Aneurysms still being a serious complication in patients with BD, but treated early, the outcome is good. <h3>Disclosure of Interest</h3> None Declared
COMBINED IMPACT OF CHRONIC KIDNEY DISEASE AND ANEMIA ON LONG-TERM CLINICAL OUTCOMES AFTER PERCUTANEOUS CORONARY INTERVENTION IN THE DRUG-ELUTING STENT ERA
Authors: Yudai Yano, Yoshikazu Hiasa, Takahashi Tatefumi, Hirotoshi Chen, Shin-ichiro Miyazaki, Riyo Ogura, Hitoshi Miyajima, Ken-ichiro Yuba, Keitaro Mahara, Shinobu Hosokawa, Kouichi Kishi, Ryuuji Ohtani
Journal: Journal of the American College of Cardiology (2010)
The Diagnosis of Symptomatic Coronary Artery Disease by Multiple Noninvasive Techniques: Correlation with Angiographic Findings and Proposal for a Quantitative Clinical Index.
Authors: P. F. Cohn
Journal: Annals of Internal Medicine (1971)

Meeting Abstracts1 May 1971The Diagnosis of Symptomatic Coronary Artery Disease by Multiple Noninvasive Techniques: Correlation with Angiographic Findings and Proposal for a Quantitative Clinical Index.P. F. Cohn, M.D., P. S. Vokonas, M.D., R. A. Williams, M.D., M. V. Herman, M.D., F.A.C.P., R. Gorlin, M.D., F.A.C.P.P. F. Cohn, M.D.Search for more papers by this author, P. S. Vokonas, M.D.Search for more papers by this author, R. A. Williams, M.D.Search for more papers by this author, M. V. Herman, M.D., F.A.C.P.Search for more papers by this author, R. Gorlin, M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-74-5-818_3 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptPrevious attempts by our laboratory to diagnose coronary artery disease by means of single noninvasive measures have had only limited success. It has been our experience that abnormalities frequently observed in coronary artery disease patients (such as positive exercise tests) are not uncommon in patients with chest pain syndromes and normal coronary arteriograms; therefore, the presence of such abnormalities alone does not allow the clinician to diagnose coronary artery disease with a high degree of confidence. Similarly, the absence of these abnormalities does not exclude the disease. To evaluate more definitively the role of various noninvasive measure in diagnosing coronary... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Boston, Mass. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 May 1971Volume 74, Issue 5Page: 818-818KeywordsCoronary arteriesExerciseIschemiaResearch laboratoriesStable coronary artery disease Issue Published: 1 May 1971 PDF DownloadLoading ...
Iron Absorption in Idiopathic Haemochromatosis before, during, and after Venesection Therapy
Authors: R. Williams, F. Manenti, H. S. Williams, C. S. Pitcher
Journal: BMJ (1966)

Hodgkin's Disease-Fairley et al.Each of these agents is of benefit in the management of advanced Hodgkin's disease, though the order in which they should be used has not yet been established, nor have the results of treatment with combinations of these agents been adequately explored.We wish to thank Dr.
Human iNKT and MAIT cells exhibit a PLZF-dependent proapoptotic propensity that is counterbalanced by XIAP
Authors: Stéphane Gérart, Sophie Sibéril, Emmanuel Martin, Christelle Lenoir, Claire Aguilar, Capucine Picard, Olivier Lantz, Alain Fischer, Sylvain Latour
Journal: Blood (2012)
Cutting queues or cutting corners: waiting lists and the 1990 NHS reforms.
Authors: C. Pope
Journal: BMJ (1992)

Management of pruritus ani* Identify and treat secondary causes * Give-advice about personal hygiene * Maintain the patient's confidence * Avoid frequent unproductive clinic visits Patients tend to make repeated visits to outpatient clinics with little improvement, seeing a different doctor at each visit.There is a danger that they will become disillusioned.An honest approach is best, warning the patient that a precise cause for their condition may not be found but that by paying attention to personal hygiene their symptoms can be minimised.In chronic cases a dermatological opinion is valuable to be sure that a skin condition such as psoriasis is not being missed.
Abstract 4074: Alterations of NDP kinase A/ NM23-H1 deregulate <i>c-myc</i> transcription
Authors: Kai-Hui Chan, Larry Paris, Lin-Jen Ma, Renn-Shiuan Wei, Choon-Yee Tan, Christina L. Chang
Journal: Cancer Research (2010)

Abstract Altered expression and mutations of NDP kinase A (NDPK-A), encoded by nm23-H1, have been detected in patients with metastatic tumors. One of new functions of NDPK-A is to participate in gene regulation. However, its role in regulating c-myc transcription remains unclear. Here we demonstrate for the first time that NDPK-A specifically bound nuclease hypersensitive element (NHE) III1 of the c-myc promoter in vitro and in vivo. Metastasis-associated S120G mutation of NDPK-A (NDPK-AS120G), but not S120G and N82S double mutations (NDPK-AS120G/N82S), retained the DNA-binding activity. In human NB69 neuroblastoma and HeLa cervical cancer cells, a high level of ectopic NDPK-A or NDPK-AS120 suppressed c-myc transcription based on the CAT reporter and RT-PCR. In contrast, shRNA-mediated knockdown of NDPK-A enhanced c-myc transcription. Without the DNA-binding activity, however, NDPK-AS120G/N82S did not display an effect on c-myc transcription. NDPK-A appears to exert transcriptional suppression via not only NHE III1 but also upstream cis-element(s) of c-myc promoter. The role of NDPK-A in regulating c-myc transcription was supported by nuclear localization of NDPK-A in cells and by negative correlation of NDPK-A and c-myc mRNA levels in several human cancer subtypes. Our findings provide a link between NDPK-A alterations and c-myc transcriptional deregulation in cancer. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 101st Annual Meeting of the American Association for Cancer Research; 2010 Apr 17-21; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2010;70(8 Suppl):Abstract nr 4074.
Recent developments in Bell's palsy: Does a more recent single research paper trump a systematic review?
Authors: James A Cave
Journal: BMJ (2004)

EDITOR—I am a jobbing general practitioner, and the paper by Holland and Weiner on Bell's palsy left me confused.1 To treat somebody is a hard decision—not to treat somebody, even harder.

In 2002 the BMJ published an article about recent advances in neurology that proposed that there might be a case for prednisolone but …
Multiple Mechanisms in the Long-QT Syndrome
Authors: Dan M. Roden, Ralph Lazzara, Michael Rosen, Peter J. Schwartz, Jeffry Towbin, G. Michael Vincent
Journal: Circulation (1996)

Abstract The congenital long-QT syndrome (LQTS) is characterized by prolonged QT intervals, QT interval lability, and polymorphic ventricular tachycardia. The manifestations of the disease vary, with a high incidence of sudden death in some affected families but not in others. Mutations causing LQTS have been identified in three genes, each encoding a cardiac ion channel. In families linked to chromosome 3, mutations in SCN5A , the gene encoding the human cardiac sodium channel, cause the disease. Mutations in the human ether-a`-go-go–related gene ( HERG ), which encodes a delayed-rectifier potassium channel, cause the disease in families linked to chromosome 7. Among affected individuals in families linked to chromosome 11, mutations have been identified in KVLQT1 , a newly cloned gene that appears to encode a potassium channel. The SCN5A mutations result in defective sodium channel inactivation, whereas HERG mutations result in decreased outward potassium current. Either mutation would decrease net outward current during repolarization and would thereby account for prolonged QT intervals on the surface ECG. Preliminary data suggest that the clinical presentation in LQTS may be determined in part by the gene affected and possibly even by the specific mutation. The identification of disease genes in LQTS not only represents a major milestone in understanding the mechanisms underlying this disease but also presents new opportunities for combined research at the molecular, cellular, and clinical levels to understand issues such as adrenergic regulation of cardiac electrophysiology and mechanisms of susceptibility to arrhythmias in LQTS and other settings.
Developments in non-radioactive microsphere techniques for blood flow measurement
Authors: F. W Prinzen, R. W Glenny
Journal: Cardiovascular Research (1994)

Journal Article Developments in non-radioactive microsphere techniques for blood flow measurement Get access Frits W Prinzen, Frits W Prinzen Department of Physiology, Cardiovascular Research Institute Maastricht, University of Limburg, PO Box 616, 6200 MD Maastricht, The Netherlands: F W Prinzen; Division of Pulmonary and Critical Care Medicine, University of Washington, Seattle, Washington 98195, USA: R W Glenny. Correspondence to Dr Prinzen. Search for other works by this author on: Oxford Academic PubMed Google Scholar Robb W Glenny Robb W Glenny Department of Physiology, Cardiovascular Research Institute Maastricht, University of Limburg, PO Box 616, 6200 MD Maastricht, The Netherlands: F W Prinzen; Division of Pulmonary and Critical Care Medicine, University of Washington, Seattle, Washington 98195, USA: R W Glenny. Correspondence to Dr Prinzen. Search for other works by this author on: Oxford Academic PubMed Google Scholar Cardiovascular Research, Volume 28, Issue 10, October 1994, Pages 1467–1475, https://doi.org/10.1093/cvr/28.10.1467 Published: 01 October 1994 Article history Received: 04 January 1994 Accepted: 07 July 1994 Published: 01 October 1994
Abstract 2542: Preclinical studies of novel phosphonium salts with broad-spectrum activity
Authors: Melissa Millard, Divya Pathania, Yumna Shabaik, Laleh Taheri, Jinxia Deng, Nouri Neamati
Journal: Cancer Research (2011)

Abstract Proliferation under selective pressures exerted by an unstable microenvironment, requires tumor cells employ adaptive mechanisms that confer growth advantage. Adaptation to adverse conditions results in cellular phenotypes that typify neoplastic transformation and offer unique opportunities for selective targeting of cancer cells. Agents that target tumor cell mitochondria with high selectivity hold clinical significance due to the adaptive, modulatory and essential role of this organelle in cancer cell energy production, metabolism and apoptosis. To this end, we have identified a series of novel, mitochondriotropic phosphonium salts, (TP compounds), that have shown broad-spectrum anti-cancer and anti-angiogenic activity in preclinical evaluation. A high-throughput MTT-based screen of over 10,000 drug-like small molecules for anti-proliferative activity identified the phosphonium salts TP187, 197 and 421 and numerous close analogues as having IC50 concentrations in the sub-micromolar range. TP treatment induced cell cycle arrest, lowered oxygen consumption, and increased mitochondrial superoxide production. Administered as single agents in a mouse model of human breast cancer, TP compounds significantly decreased tumor growth with no observed toxicities. Protein microarray data demonstrated significant down-regulation of integrin and growth factor mediated signaling pathways governing key processes including cancer cell survival, proliferation and tumor angiogenesis. At low micromolar concentrations, TP compounds prevented integrin-mediated cell adhesion to fibronectin and vitronectin coated substrates and tumor cell haptotaxsis on vitronectin coated boyden chambers. Similar concentrations of TP compound also prevented growth factor induced endothelial cell tube formation in 3-D culture using basement membrane extracts. Taken together, these results suggest that as mitochondria-targeted agents, TP compounds act to inhibit tumor cell proliferation and angiogenic capacity. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 102nd Annual Meeting of the American Association for Cancer Research; 2011 Apr 2-6; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2011;71(8 Suppl):Abstract nr 2542. doi:10.1158/1538-7445.AM2011-2542
Effective Inhibition of HBV Replication in Vivo by Anti-HBx Short Hairpin RNAs
Authors: Sergio Carmona, Abdullah Ely, Carol Crowther, Naazneen Moolla, Felix H. Salazar, Patricia L. Marion, Nicolas Ferry, Marc S. Weinberg, Patrick Arbuthnot
Journal: Molecular Therapy (2005)

Exploiting the RNA interference pathway has shown promise for developing novel and effective treatment of hepatitis B virus (HBV) infection. To advance this approach, we analyzed the antiviral efficacy of a panel of 10 Pol III U6 promoter-encoded short hairpin RNAs (shRNAs) that target conserved sequences of the oncogenic HBx open reading frame. To facilitate intracellular processing, the shRNAs included mismatches in the 25-bp stem region and a terminal loop of miRNA-23. Two shRNAs (shRNA 5 and shRNA 6) showed knockdown of HBV markers by 80–100% in transfected hepatocytes and also in a murine hydrodynamic injection model of HBV replication. Intracellular processing of hairpin RNA with the intended strand bias correlated with antiviral efficacy. Moreover, markers of HBV replication were inhibited without inducing genes associated with the nonspecific interferon response. To assess the antiviral efficacy of the shRNAs in a context that is similar to natural HBV infection, shRNA-encoding cassettes were tested against the virus in a HBV transgenic murine model. When delivered using recombinant adenovirus vectors, U6 shRNA 5 and U6 shRNA 6 mediated significant HBV knockdown. Collectively, these observations indicate that U6 shRNA 5 and U6 shRNA 6 are promising candidates for therapy of chronic HBV infection.
miR-135b mediates NPM-ALK–driven oncogenicity and renders IL-17–producing immunophenotype to anaplastic large cell lymphoma
Authors: Hironori Matsuyama, Hiroshi I. Suzuki, Hikaru Nishimori, Masaaki Noguchi, Takashi Yao, Norio Komatsu, Hiroyuki Mano, Koichi Sugimoto, Kohei Miyazono
Journal: Blood (2011)
OBSERVATIONS ON THE VOCAL CORDS IN ONE THOUSAND CASES OF GOITER
Authors: JUSTUS MATTHEWS
Journal: JAMA (1910)

My report is made on the observations of the vocal cords in 1,000 cases of goiter examined during the past two years. About 95 per cent, of the patients were operated on; all were examined before operation and reexamined after operation. The anatomy of the larynx may be passed over with the exception of the motor nerve supply of its intrinsic muscles, which will be considered only with reference to liability to paralysis from pressure by enlargement of the thyroid gland. The cricothyroid muscles, which are the tensors of the vocal cords, are supplied by the external branches of the superior laryngeal nerves from the pneumogastrics. These branches enter the muscles so high that only the largest lobes, which extend unusually high on the throat,
Abstract 3047: Hypoxia leads to deregulation of PI3K/AKT/mTOR signaling in prostate cancer stem cells
Authors: Maximilian Marhold, Erwin Tomasich, Zuzana Pernicová, Radek Fedr, Karel Soucek, Andreas Spittler, Michael Krainer, Peter Horak
Journal: Cancer Research (2014)

Abstract Tumor initiating subpopulations of cancer cells, also known as cancer progenitor or cancer stem cells (CSCs) were recently identified and characterized in prostate cancer. Emerging evidence suggests that hypoxia-inducible factor 1 alpha (HIF1A) contributes to CSC maintenance and influences the PI3K/AKT/mTOR axis, a pathway which is frequently altered in prostate cancer. In our study, we assessed the effects of hypoxia on PI3K/AKT/mTOR signaling in a subset of basal prostate cancer stem cells in a murine model of prostate cancer. First, we successfully isolated Lin-/Sca-1+/CD49f+ basal stem cell subpopulations from primary prostate tumors of TRAMP (transgenic adenocarcinoma of mouse prostate) mice. We observed a consistent decrease in S6 phosphorylation within the CSC subpopulation, in agreement with an mTOR pathway inhibition. However, AKT phosphorylation in the CSC subpopulation was simultaneously elevated, thus prompting further investigations. To analyze the molecular pathways leading to this deregulation, we used a cell line model and isolated Sca-1+/CD49f+ CSC-like subpopulations from the murine prostate cancer cell line TRAMP-C1 and CD44+/CD49f+ CSC-like subpopulations from the androgen independent human prostate cancer cell line DU145. We used sphere formation assays and expression of Notch 1 and Oct 3/4 to confirm the stem and progenitor cell properties of the sorted subpopulations. We could confirm the decrease in mTOR/S6 signaling and identify the upregulation of AKT through IRS-1 mediated feedback loop in prostate CSC-like cells under hypoxic conditions. This AKT/mTOR deregulation was promptly reversed in normoxia, suggestive of the involvement of hypoxia inducible factors. We found elevated HIF1A protein levels as well as increased target gene expression in CSC subpopulations in vitro and in vivo. Further, lentiviral knockdown of HIF1A restored AKT/mTOR activity in CSC-like cells. We could show that CSC-like prostate cancer cells with elevated expression of basal stem cell markers, such as CD44, Sca-1 or CD49f, show a hypoxic deactivation of feedback inhibition on AKT signaling through IRS-1. In light of these results, we propose that deregulation of the PI3K/AKT/mTOR pathway via HIF1A may be critical for cancer stem cell quiescence and maintenance, slowing down cancer stem cell metabolism and growth via mTOR and promoting their survival via AKT signaling. Citation Format: Maximilian Marhold, Erwin Tomasich, Zuzana Pernicová, Radek Fedr, Karel Soucek, Andreas Spittler, Michael Krainer, Peter Horak. Hypoxia leads to deregulation of PI3K/AKT/mTOR signaling in prostate cancer stem cells. [abstract]. In: Proceedings of the 105th Annual Meeting of the American Association for Cancer Research; 2014 Apr 5-9; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2014;74(19 Suppl):Abstract nr 3047. doi:10.1158/1538-7445.AM2014-3047
Serum Myoglobin in Rhabdomyolysis
Authors: Helmut F. Kaiser
Journal: JAMA (1982)

<h3>To the Editor.—</h3> Recently, Porter et al (1981;245:1545) reported two cases of rhabdomyolysis in patients with<i>Streptococcus</i>and picornavirus infection. The observations of the authors are of importance because they add these infectious agents to the already long list of viruses and bacteria involved in the pathogenesis of atraumatic rhabdomyolysis and myoglobinuric renal failure. However, we have some objections concerning the serum myoglobin measurement mentioned by the authors in case 1. They state that despite extremely elevated serum creatine phosphokinase levels (114,000 IU/L), "the serum myoglobin assay findings were normal." According to our experience with 23 cases of atraumatic rhabdomyolysis, this seems to be impossible: muscle damage causing enzyme leakage invariably leads to concomitant increases in serum myoglobin concentrations. Even in cases with minor degrees of rhabdomyolysis (as judged from serum creatine phosphokinase levels), serum myoglobin is regularly and notably elevated.<sup>1,2</sup>In the presence of renal failure, as in
Transcaval endoscopic ultrasound-guided fine needle aspiration of a right adrenal lesion
Authors: F. Lococo, F. Attili, E. Meacci, G. Petrone, F. Inzani, P. Granone, G. Costamagna, A. Larghi
Journal: Endoscopy (2013)

A 66-year-old man who had recently been found on radiological examination to have a 43 × 68-mm right pulmonary mass adjacent to the esophagus ([Fig. 1 a]) and an 18 × 16-mm right adrenal lesion that was highly suspicious of a metastasis ([Fig. 1 b]) was sent to our center for endoscopic ultrasound (EUS)-guided tissue diagnosis of both lesions.
Erratum: Corrigendum: Nuclear BK channels regulate gene expression via the control of nuclear calcium signaling
Authors: Boxing Li, Wei Jie, Lianyan Huang, Peng Wei, Shuji Li, Zhengyi Luo, Allyson K Friedman, Andrea L Meredith, Ming-Hu Han, Xin-Hong Zhu, Tian-Ming Gao
Journal: Nature Neuroscience (2014)
Retraction of: p2y5/LPA6 attenuates LPA1-mediated VE-cadherin translocation and cell-cell dissociation through G12/13 protein-Src-Rap1
Authors: T. Kimura, C. Mogi, K. Sato, H. Tomura, H. Ohta, D.-S. Im, A. Kuwabara, H. Kurose, M. Murakami, F. Okajima
Journal: Cardiovascular Research (2012)
Thyroiditis and Thyrotoxicosis
Authors: Steven G. Dorfman
Journal: JAMA (1978)

The classical course of subacute thyroiditis was described by Volpe et al 1 : following a viral prodrome, patients experience thyroidal pain and swelling, and large amounts of thyroxine and triiodothyronine are released from the gland, resulting in thyrotoxicosis that lasts for several months. The high levels of thyroid hormone, which suppress thyroid-stimulating hormone (TSH), and the inability of the damaged gland to trap iodine lead to a decreased (1% to 2%) radioactive iodine uptake (RAIU). Following the thyrotoxicosis, euthyroidism ensues, in which the levels of triiodothyronine and thyroxine return to normal and the tender goiter resolves. During euthyroidism, the levels of TSH and the RAIU return to normal or may even become transiently elevated. Most patients do not progress beyond this phase, but 25% have transient hypothyroidism lasting two to six months. Almost all of these patients later recover, and indexes of thyroid function gradually return to normal.  Papapetrou and