tbuckley/cabot-search huggingface dataset:
Abstract P290: Tai Chi Downregulates Pro-inflammatory Cytokines in Women With Increased Cardiometabolic Risk
Authors: Jo Robins, Jamie L Sturgill
Journal: Circulation (2015)

Authors: Jo Lynne Robins, PhD, RN; Assistant Professor, Virginia Commonwealth University School of Nursing & Jamie L. Sturgill, PhD; Assistant Professor, Virginia Commonwealth University School of Nursing. Objectives: To examine the effects of a unique tai chi intervention designed to impact inflammatory factors associated with cardiometabolic risk (CMR) in women with early indicators of risk for cardiovascular disease (CVD). Methods: A randomized clinical trial was conducted in women with increased CMR, as evidenced by increased abdominal adiposity and a family history of CVD. To measure multiple cytokines/chemokines/growth factors, cryopreserved plasma samples were batch-processed using commercially prepared 17-plex kits with a Bio-Plex Pro™ (BioRad, Inc.) magnetic bead system (intra-assay variability < 5%, interassay variability < 9 %, cross-reactivity < 1.0%). Findings: In a sample of 63 women, there were no significant differences in cytokine/growth factor levels at baseline. However, following the 8...
Abstract P380: Coronary Artery Disease Extent is Predictive of Heart Failure Incidence After Myocardial Infarction
Authors: Yariv Gerber, Susan A Weston, Maurice E Sarano, Sheila M Manemann, Alanna M Chamberlain, Ruoxiang Jiang, Veronique L Roger
Journal: Circulation (2015)

Background: Little is known about the association between coronary artery disease (CAD) and the risk of heart failure (HF) after myocardial infarction (MI), and whether it differs by reduced (HFrEF) or preserved (HFpEF) ejection fraction (EF) has yet to be determined. Subjects and Methods: Olmsted County, Minnesota residents (n=1,924; mean age, 64 years; 66% male) with first MI diagnosed in 1990-2010 and no prior HF were followed through 2013. Framingham Heart Study criteria were used to define HF, which was further classified according to EF (applying a 50% cutoff). The extent of angiographic CAD was defined at index MI according to the number of major epicardial coronary arteries with ≥50% lumen diameter obstruction. Fine &amp; Gray and Cox proportional hazards regression models were used to assess the association of CAD categories with incidence of HF, and multiple imputation methodology was applied to account for the 19% with missing EF data. Results: During a mean (SD) follow-up of 6.7 (5.9) years, 594 patients developed HF. Adjusted for age and sex, with death considered a competing risk, the cumulative incidence rates of HF among patients with 1- (n=581), 2- (n=622), and 3-vessel disease (n=721) were 11.2%, 14.6% and 20.5% at 30 days; and 18.1%, 22.3% and 29.4% at 5 years after MI, respectively. The increased risk of HF with greater number of occluded vessels was only modestly attenuated after further adjustment for patient and MI characteristics, and did not differ materially by EF (Table). Conclusions: The extent of angiographic CAD expressed by the number of diseased vessels is independently associated with HF incidence after MI. The association is evident promptly after MI and applies to both HFrEF and HFpEF.
388. Protection of End-Organ Damage in Stroke-Prone Spontaneously Hypertensive Rats by Intramuscular Injection of AAV Vector Expressing Interleukin-10
Authors: Joke Lievens, Jan Snoeys, Katrien Vekemans, Sophie Van Linthout, Ronald de Zanger, Désiré Collen, Eddie Wisse, Bart De Geest
Journal: Molecular Therapy (2004)

The hepatotropism and intrahepatic distribution of adenoviral vectors may be species dependent. Hepatocyte transduction was evaluated in three rabbit strains after transfer with E1E3E4-deleted adenoviral vectors containing a hepatocyte specific α1 -antitrypsin promoter driven expression cassette (AdAT4). Intravenous administration of 4 × 1012 particles/kg of AdAT4 induced human apo A-I levels above 40 mg/dl in Dutch Belt, but below 1 mg/dl in New Zealand White and Fauve de Bourgogne rabbits. Human apo A-I levels did not correlate with transgene DNA levels, but with human apo A-I mRNA/DNA ratio in the liver. This human apo A-I mRNA/DNA ratio in the liver was 1.6 ± 0.37 at day 14 in Dutch Belt rabbits and was 77-fold (p<0.01) and 69-fold (p<0.01) higher than in New Zealand White and Fauve de Bourgogne rabbits, respectively, indicating strain differences of intrahepatic transgene DNA distribution. Diameters of sinusoidal fenestrae determined by transmission electron microscopy were significantly (p=0.0014) larger in Dutch Belt (124 ± 3.4 nm) than in New Zealand White (108 ± 1.3 nm) and Fauve de Bourgogne (105 ± 2.6 nm) rabbits. Since the diameter of adenoviral particles determined by cryo-electon microscopy is 110 nm, the observed differences in diameters of sinusoidal fenestrae are a critical determinant of hepatocyte transduction by adenoviral vectors.The number of fenestrae per μm2 determined by scanning electron microscopy was not significantly different between New Zealand White rabbits (19 ± 0.66) and Dutch Belt rabbits (19 ± 0.60) and was not determined in Fauve de Bourgogne rabbits. Consitent with the presence of an anatomical barrier for the passage of adenoviral vectors at the level of the sinusoidal endothelium, intraportal transfer preceded by injection of sodium decanoate, which enhances endothelial permeability, increased human apo A-I levels 32- and 120-fold in New Zealand White and Fauve de Bourgogne rabbits, respectively, but did not affect expression in Dutch Belt rabbits. In conclusion, size of sinusoidal fenestrae appears to be a critical determinant of hepatocyte transduction after adenoviral transfer. The existence of several pathophysiological conditions in humans in which the anatomy of the sinusoidal endothelium is altered, underscores the relevance of these observations for the development of hepatocyte directed gene transfer. Since the diameter of lentiviral vectors is higher than adenoviral vectors and since genetic variation in the diameters of sinusoidal fenestrae in humans with a healthy liver is unknown, this determinant of parenchymal liver cell transduction should be taken into account for the development of cllinical gene transfer.
A study of design an original questionnaire for evaluating risks of lung cancer
Authors: Bojiang Chen, Dongmei Wang, Weimin Li, Dan Liu
Journal: European Respiratory Journal (2011)

Background: No simlpe questionnaire has been published, though risk factors of lung cancer were studied for long.

Objective: To explore a questionnaire for people self-evaluating.

Methods: A questionnaire was designed and applied to test its value.

Results: See Table 1. Coefficient of reliability and validity were 0.99 and 0.59. Difference of scores between 94 patients and 252 controls confirmed its differentiating power. Threshold (116) was identified by a survey including 2161 individuals. Then, 7697 volunteers completed a 3-year prospective study, and 16 lung cancer were detected in the risk group with 1257 persons (1.28%), while another 4 in the non-risk cohort (0.06%).

View this table:

Table 1. Self-evaluation scoring questionnaire for high-risk individuals of lung cancer





Conclusion: The questionnaire is a useful method for self-evaluation.
Abstract MP09: Deep Terminal Negativity of the P Wave in V1 is Associated with Sudden Cardiac Death in the Community: The Atherosclerosis Risk in Communities Study
Authors: Larisa G Tereshchenko, Yiyi Zhang, Dan E Arking, Nona Sotoodehnia, David S Siscovick, Rajat Deo, Sunil K Agarwal, Wendy S Post, Ronald Berger, Scott Solomon, Eliseo Guallar, Josef Coresh, Mark E Josephson, Elsayed Z Soliman
Journal: Circulation (2014)

Background: Deep terminal negativity of the P wave in V1 (P prime in V1, PPV1) defined as PPV1 ≤ -0.1mV in amplitude and ≥40 ms in duration (one small box on ECG grid) is sign of a left atrium enlargement, and a component in the Romhilt-Estes score of left ventricular hypertrophy (LVH). LVH is known to be associated with the risk of sudden cardiac death (SCD). Deep PPV1 negativity is also associated with atrial fibrillation (AF) and stroke; both have been linked to SCD as well. However, it is unknown whether or not PPV1 negativity is independently associated with SCD. Method: Baseline resting digital 12-lead ECGs of 13232 ARIC cohort participants (mean age 53.9±5.7 y; 5760 [43.5%] men; 9747 [73.7%] white) were analyzed. Individuals with prevalent baseline coronary heart disease (CHD), heart failure (HF), or QRS ≥ 120 ms were excluded. The ECGs were analyzed using a 12SL TM algorithm (GE Healthcare, Wauwatosa, WI, USA). Amplitude and duration of PPV1 was automatically measured. Results: Deep PPV1 negativity was observed in 97 (0.73%) participants. During a median follow-up of 14 years, 182 participants had SCD. In multivariable competing risks regression analysis, deep PPV1 negativity was significantly associated with SCD after adjustment for baseline risk factors of CHD and SCD (age, sex, race, diabetes, smoking, alcohol consumption, cholesterol, triglycerides, body mass index, serum creatinine, albumin, systolic blood pressure, use of antihypertensive, QT-prolonging medications, level of physical activity, mean heart rate, QTc, QRS duration, ECG-LVH by Cornell product), and incident HF, AF, stroke [subHR 3.8 (95%CI 1.88-7.69); P&lt;0.0001]. Deep PPV1 negativity showed 7% sensitivity and 99% specificity for SCD prediction. Conclusion: In apparently CV healthy, middle-aged individuals, deep terminal negativity of P-wave in V1 is associated with about 4-times higher risk of SCD during 14 years of follow-up. Further studies should explore the cardiac substrate underlying presence of this marker and its use for risk stratification.
Prion Diseases Linked
Authors: Rebecca Voelker
Journal: JAMA (2000)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Influence of Diabetes Mellitus on Clinical Outcome in the Thrombolytic Era of Acute Myocardial Infarction fn1fn1The GUSTO-I study was supported by a combined grant from Bayer, New York, New York; CIBA-Corning, Medfield, Massachusetts; Genetech, South San Francisco, California; ICI Pharmaceuticals, Wilmington, Delaware; and Sanofi Pharmaceuticals, Paris, France.
Authors: Koon-Hou Mak, David J. Moliterno, Christopher B. Granger, Dave P. Miller, Harvey D. White, Robert G. Wilcox, Robert M. Califf, Eric J. Topol
Journal: Journal of the American College of Cardiology (1997)
Thrombosis After Implantation of Drug-Eluting Stents
Authors: Emmanuel Marret, Jean-Phillipe Collet, Pierre Albaladejo, Gilles Montalescot
Journal: JAMA (2006)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Homocysteine: a risk factor for retinal venous occlusive disease1,2 1The opinions or assertions contained in this article are the private views of the authors and are not to be construed as official or reflective of the views of the Department of the United States Army or the United States Department of Defense. 2The authors have no financial interest in any product described in this article.
Authors: Bruce A Brown, Jeffrey L Marx, Thomas P Ward, Rodney D Hollifield, John S Dick, John J Brozetti, Robin S Howard, Allen B Thach
Journal: Ophthalmology (2002)
Platelet adhesion to collagen types I through VIII under conditions of stasis and flow is mediated by GPIa/IIa (alpha 2 beta 1-integrin)
Authors: EU Saelman, HK Nieuwenhuis, KM Hese, PG de Groot, HF Heijnen, EH Sage, S Williams, L McKeown, HR Gralnick, JJ Sixma
Journal: Blood (1994)
A Modality-Specific Feedforward Component of Choice-Related Activity in MT
Authors: Alexandra Smolyanskaya, Ralf M. Haefner, Stephen G. Lomber, Richard T. Born
Journal: Neuron (2015)

The activity of individual sensory neurons can be predictive of an animal's choices. These decision signals arise from network properties dependent on feedforward and feedback inputs; however, the relative contributions of these inputs are poorly understood. We determined the role of feedforward pathways to decision signals in MT by recording neuronal activity while monkeys performed motion and depth tasks. During each session, we reversibly inactivated V2 and V3, which provide feedforward input to MT that conveys more information about depth than motion. We thus monitored the choice-related activity of the same neuron both before and during V2/V3 inactivation. During inactivation, MT neurons became less predictive of decisions for the depth task but not the motion task, indicating that a feedforward pathway that gives rise to tuning preferences also contributes to decision signals. We show that our data are consistent with V2/V3 input conferring structured noise correlations onto the MT population.
How was it for you?
Authors: J S Allum
Journal: BMJ (1994)

I have been on the receiving end of questions such as “How does it feel to be on the receiving end?” and “You don't need any help do you?” for much of this past year. The reason? A common condition, experienced by hundreds of thousands of women every year: pregnancy. Friends and colleagues were amused by my condition because I am a lecturer in obstetrics and gynaecology. Well, to those who asked, but especially to those who did not, let me tell you how I found this experience.

Within days of me confirming my pregnancy, early morning sickness arrived. Well actually, all day and night nausea, and frequent vomiting. “This is a common condition, which usually resolves around 12 to 14 weeks,” states literature widely available to the newly pregnant. I tried acupressure bands, which made my wrists hurt but reduced the metallic taste in my mouth; ginger, which made no difference at all to my symptoms; and once, having been sick five times in an hour while doing an antenatal clinic, intramuscular metoclopramide. The problem was what to eat and drink. Strawberry flavoured milk shakes and chicken breasts became staple foods until around 18 weeks, when the vomiting ceased.

I had a new problem then. I had decided, with my husband, that I should have an …
Abstract 19569: High-sensitive Troponin T Cut-off Value for Myocardial Infarction After Vascular Surgery
Authors: Danielle M Gualandro, Gisela B Llobet, Pai C Yu, Daniela Calderaro, Andre C Marques, Adriana F Pastana, Bruno Caramelli
Journal: Circulation (2014)

Introduction: Isolated high sensitive cardiac troponin T (hsTnT) elevations after vascular surgery are frequent and may lead to over diagnosis of myocardial infarction (MI). The aim of our study was to determine the accuracy of the current hsTnT cut-off value in the setting of acute coronary syndrome (ACS) after vascular surgery. Methods: Between August 2012 and March 2014, we included 337 consecutive patients submitted to arterial vascular surgery for which cardiac perioperative evaluation was requested. Perioperative surveillance included 12-lead electrocardiogram and hsTnT measurements on the three days following surgery. Patients were followed-up by cardiologists until hospital discharge and monitored for ACS. A receiver operating characteristics (ROC) curve analysis was performed to determine the hsTnT cut-off value with better accuracy for the diagnosis of perioperative ACS. Results: Of the 337 patients included, 240 (71.2%) presented hsTnT elevation above the manufacturer-provided cut-off value (0.014 ng/ml), whereas 22 (6.5%) fulfilled criteria for ACS. Median post-operative peak hsTnT of ACS patients were 0.215 ng/ml (IQR 0.043-0.493 ng/ml), versus 0.02 ng/ml (IQR 0.012-0.038 ng/ml) in patients that did not have events (P&lt;0.001). After performing a ROC curve analysis (AUC = 0.876), we found that the manufacture-provided cutoff hsTnT value yielded a sensitivity of 100% and specificity of only 35% for diagnosis of perioperative ACS. A new hsTnT cutoff value of 0.0415 ng/ml was obtained with 86.4% sensitivity and 77% specificity for the diagnosis of perioperative ACS. Ninety-two patients (27.3%) had hsTnT elevations above the proposed new cutoff. Conclusion: A different hsTnT cutoff value of 0.0415 ng/ml is proposed and could be more useful for the diagnosis of perioperative ACS.
Sedation for Diagnostic Upper Gastrointestinal Endoscopy: a Survey of the Francophone Pediatric Hepatology, Gastroenterology, and Nutrition Group
Authors: L. Michaud
Journal: Endoscopy (2005)

A survey of sedation usage in children undergoing diagnostic upper gastrointestinal endoscopy was undertaken among the members of the Francophone Pediatric Hepatology, Gastroenterology, and Nutrition Group.A questionnaire regarding the mode of sedation used for noninterventional upper gastrointestinal endoscopy, relative to the patient's age and clinical condition, was sent to all members of the Group. The sample included 51 pediatric endoscopy centers (33 university hospitals, eight general hospitals, and 10 private practices).The response rate was 84 % (43 of 51) overall, and 100 % for university hospitals. Forty percent of the pediatric endoscopy centers routinely offered children and/or parents a choice between general anesthesia and conscious sedation. Only 14 % of the pediatric endoscopists surveyed routinely conducted upper gastrointestinal endoscopy under general anesthesia, irrespective of the patient's age or the indication for endoscopy. Patients under the age of 6 months underwent endoscopy as follows: 35 % under conscious sedation, 22 % under general anesthesia, and 43 % with no sedation. After the age of 6 months, endoscopy was conducted as follows: 45 % under conscious sedation, 47 % under general anesthesia, and 8 % with no sedation. Midazolam was the most common drug used for conscious sedation. In patients aged 3 - 5, inhaled nitrous oxide was used instead of midazolam for conscious sedation in 12 % of pediatric endoscopies, and local anesthesia with lidocaine (Xylocaine) in 24 %. In those over the age of 5, the proportions of centers using inhaled nitrous oxide and lidocaine increased to 19 % and 42 %, respectively.These results clearly show that the mode of sedation used in noninterventional upper gastrointestinal endoscopy in the pediatric age group is highly variable.
Abstract P257: Efficacy of Teen Battle Chef Program to Shift the Academic Performance and Health Behaviors in NYC High School Students
Authors: Hyunwoo Park, Lynn Fredericks, Nicole M Sliva, Jun Wang, Erica D Irvin, Judith Wylie-Rosett, Shawn G Hayes
Journal: Circulation (2015)

Introduction: Adolescent obesity is one of the leading public health concerns in the United States. Children who are overweight as adolescents are much more likely to become obese adults. Providing nutrition education is a powerful resource for dietary behavioral change among adolescents and children. Teen Battle Chef (TBC), a component of the HealthCorps Living Labs program, uses culinary and nutrition education to promote behavioral change by empowering youth on multiple levels. This study examines impact of the TBC component of HealthCorps on NYC high school students’ food behaviors, leadership skills, attendance and academic performance. Hypothesis: That participation in Teen Battle Chef will increase attendance, academic and food behavior indicators Methods: We examined several food behaviors, leadership traits, attendance and academic performance of TBC students in the 14 NYC HealthCorps high schools. The TBC curriculum was implemented all 14 schools and a total of 176 students participated in the intervention and 40 students in the comparison group. Pre and Post surveys were conducted. Students from both interventional and comparison groups completed the same survey. Additionally, school performance data in a subset of students from the previous school year in the same schools were examined to determine whether participation affected school performance. Academic data (2012-13) from a total of 88 TBC from 2012-13 were compared to the entire school population. These included attendance, SAT scores, and graduation. Results: The TBC intervention group had significantly greater improvements in key food behavior indicators. Students reported an increased “energy level” [t=+2.90; p&lt;0.01]; more likely to consume fruit [t=-2.17; p&lt;0.05], carrots [t=-2.56; p&lt;0.05], and less likely to drink soda [t=2.30; p&lt;0.05]. The TBC group significantly increased their overall dietary quality (0.114; p=0.03) compared with the control group (0.006; p=0.90). An indication of leadership development, participants had significantly greater improvement in discussing the value of local foods with others (t=-3.31; p&lt;0.01). Compared with previous year’s cohort, the mean SAT scores for TBC participants were significantly higher than overall school scores. Additionally, TBC participants attendance rate was 95%, compared to the school attendance rate of 86%. Conclusion: This study provides strong evidence that TBC helps develop leadership, teamwork, culinary skills, nutrition knowledge, food systems and self-efficacy for high school students. In addition, our study explicitly shows that TBC students improve their academic performance and attendance and are motivated to succeed in school as a result of their participation in the TBC/HealthCorps programs.