tbuckley/cabot-search huggingface dataset:
Phylogenetic clustering of hepatitis C virus among people who inject drugs in Vancouver, Canada
Authors: Brendan Jacka, Tanya Applegate, Mel Krajden, Andrea Olmstead, Richard P. Harrigan, Brandon D.L. Marshall, Kora DeBeck, M.-J. Milloy, Francois Lamoury, Oliver G. Pybus, Viviane D. Lima, Gkikas Magiorkinis, Vincent Montoya, Julio Montaner, Jeffrey Joy, Conan Woods, Sabina Dobrer, Gregory J. Dore, Art F.Y. Poon, Jason Grebely
Journal: Hepatology (2014)

Little is known about factors associated with hepatitis C virus (HCV) transmission among people who inject drugs (PWID). Phylogenetic clustering and associated factors were evaluated among PWID in Vancouver, Canada. Data were derived from the Vancouver Injection Drug Users Study. Participants who were HCV antibody-positive at enrolment and those with HCV antibody seroconversion during follow-up (1996 to 2012) were tested for HCV RNA and sequenced (Core-E2 region). Phylogenetic trees were inferred using maximum likelihood analysis and clusters were identified using ClusterPicker (90% bootstrap threshold, 0.05 genetic distance threshold). Factors associated with clustering were assessed using logistic regression. Among 655 eligible participants, HCV genotype prevalence was: G1a: 48% (n = 313), G1b: 6% (n = 41), G2a: 3% (n = 20), G2b: 7% (n = 46), G3a: 33% (n = 213), G4a: &lt;1% (n = 4), G6a: 1% (n = 8), G6e: &lt;1% (n = 1), and unclassifiable: 1% (n = 9). The mean age was 36 years, 162 (25%) were female, and 164 (25%) were HIV+. Among 501 participants with HCV G1a and G3a, 31% (n = 156) were in a pair/cluster. Factors independently associated with phylogenetic clustering included: age &lt;40 (versus age ≥40, adjusted odds ratio [AOR] = 1.64; 95% confidence interval [CI] 1.03, 2.63), human immunodeficiency virus (HIV) infection (AOR = 1.82; 95% CI 1.18, 2.81), HCV seroconversion (AOR = 3.05; 95% CI 1.40, 6.66), and recent syringe borrowing (AOR 1.59; 95% CI 1.07, 2.36). Conclusion : In this sample of PWID, one-third demonstrated phylogenetic clustering. Factors independently associated with phylogenetic clustering included younger age, recent HCV seroconversion, prevalent HIV infection, and recent syringe borrowing. Strategies to enhance the delivery of prevention and/or treatment strategies to those with HIV and recent HCV seroconversion should be explored, given an increased likelihood of HCV transmission in these subpopulations. (Hepatology 2014;60:1571–1580)
Abstract 16485: The Nitroxyl Donor 1-Nitrosocyclohexyl Acetate Limits Cardiac Superoxide Upregulation and Diastolic Dysfunction in a Mouse Model of Diabetic Cardiomyopathy
Authors: Rebecca H Ritchie, Nga Cao, Yung George Wong, Sarah Rosli, Helen Kiriazis, Karina Huynh, Chengxue Qin, Xiao-Jun Du, Barbara K Kemp-Harper
Journal: Circulation (2014)

Nitroxyl (HNO), a redox congener of NO•, is a novel regulator of cardiovascular function combining vasodilator and positive inotropic properties. Our previous studies have demonstrated these properties occur concomitantly in the intact heart; HNO moreover also exhibits antihypertrophic and superoxide-suppressing actions. HNO donors may thus offer favorable actions in heart failure. The impact of chronic HNO donor administration has however yet to be reported in this context. We tested the hypothesis that the HNO donor 1-nitrosocyclohexyl acetate (1-NCA) limits cardiomyocyte hypertrophy and left ventricular (LV) diastolic dysfunction in a mouse model of diabetic cardiomyopathy in vivo. Male 6 week-old FVB/N mice received either streptozotocin (55 mg/kg/day i.p. for 5 days, n=17), to induce type 1 diabetes, or citrate vehicle (n=16). After 4 weeks of hyperglycemia, mice were allocated to 1-NCA therapy (83mg/kg/day i.p.) or vehicle, and followed for a further 4 weeks. As shown in the table, blood glucose was unaffected by 1-NCA. LV diastolic dysfunction was evident in diabetic mice, measured as echocardiography-derived A wave velocity, deceleration time and E:A ratio; LV systolic function was preserved. Diabetes-induced diastolic dysfunction was accompanied by increased LV cardiomyocyte size, hypertrophic and pro-fibrotic gene expression, and upregulation of LV superoxide. These characteristics of diabetic cardiomyopathy were largely prevented by 1-NCA treatment. Selectivity of 1-NCA as a donor of HNO versus NO• was demonstrated by the sensitivity of the coronary vasodilation response of 1-NCA to the HNO scavenger L-cysteine (4mM), but not to the NO• scavenger hydroxocobalamin (50μM), in the normal rat heart ex vivo (n=3-7). Collectively, our studies provide the first evidence that HNO donors may represent a promising new strategy for the treatment of diabetic cardiomyopathy, and implies their therapeutic efficacy in settings of chronic heart failure.
The in vivo kinetics of tissue factor messenger RNA expression during human endotoxemia: relationship with activation of coagulation
Authors: Rendrik F. Franco, Evert de Jonge, Pascale E. P. Dekkers, Janneke J. Timmerman, C. Arnold Spek, Sander J. H. van Deventer, Peter van Deursen, Liesbeth van Kerkhoff, Bob van Gemen, Hugo ten Cate, Tom van der Poll, Pieter H. Reitsma
Journal: Blood (2000)
The European Committee on Antimicrobial Susceptibility Testing-Subcommittee on Antifungal Susceptibility Testing (EUCAST-AFST) EUCAST Technical Note on fluconazole.
Authors: J-L Rodriguez Tudela, JP Donnelly, MC Arendrup, S Arikan, F Barchiesi, J Bille, E Chryssanthou, M Cuenca-Estrella, E Dannaoui, D Denning, W Fegeler, P Gaustad, N Klimko, C Lass-Floerl, C Moore, M Richardson, A Schmalreck, J Stenderup, A Velegraki, P Verweij
Journal: Clinical Microbiology and Infection (2009)
CRIMINAL INTERROGATION WITH THE LIE DETECTOR; EIGHT YEARS' EXPERIENCE BY THE MICHIGAN STATE POLICE
Authors: Le Moyne Snyder
Journal: Annals of Internal Medicine (1943)

Article1 April 1943CRIMINAL INTERROGATION WITH THE LIE DETECTOR; EIGHT YEARS' EXPERIENCE BY THE MICHIGAN STATE POLICELE MOYNE SNYDER, M.D.LE MOYNE SNYDER, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-18-4-551 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptDuring the era since the last war the science of criminal investigation has enjoyed tremendous growth. This quarter of a century has witnessed the development of fingerprinting into a common, everyday procedure. Scientific firearms identification (improperly called "ballistics") is a development of the last few years. The employment of blood grouping examinations in cases of contested paternity, scientific determination of alcoholic intoxication and many other valuable procedures have all come into use during this same time. The medical profession can take pride in the fact that its members have contributed so generously to the development of this new field.Probably...1 LOMBROSO C: L'homme criminel, 2nd ed., 1895, i, 336-346. Google Scholar2 BORCHARD EM: Convicting the innocent, 1932, Yale University Press, New Haven, Conn. Google Scholar3 INBAU FE: Lie detection and criminal interrogation, 1942, The Williams & Wilkins Co., Baltimore. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: East Lansing, Michigan*Received for publication February 8, 1943. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 April 1943Volume 18, Issue 4Page: 551-563KeywordsAlcoholicsBloodFirearm injuriesIntoxication ePublished: 1 December 2008 Issue Published: 1 April 1943 PDF downloadLoading ...
CHRONIC BRUCELLOSIS (UNDULANT FEVER); AN ANALYTICAL STUDY OF THE POSITIVE REACTORS AMONG SCHOOL CHILDREN
Authors: Fred E. Angle, William H. Algie
Journal: Annals of Internal Medicine (1939)

Article1 February 1939CHRONIC BRUCELLOSIS (UNDULANT FEVER); AN ANALYTICAL STUDY OF THE POSITIVE REACTORS AMONG SCHOOL CHILDRENFRED E. ANGLE, F.A.C.P., WILLIAM H. ALGIE, F.A.C.P.FRED E. ANGLE, F.A.C.P.Search for more papers by this author, WILLIAM H. ALGIE, F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-12-8-1189 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe United States Department of Agriculture in the past few years has made an extensive survey of the incidence of Bang's disease among dairy cattle in the United States. It was found that an average of 38.4 per cent of the herds tested contained positive reactors. In the infected herds 14.9 per cent were positive, of the total 11,858,859 cattle 8 per cent gave a positive agglutination test.1Although there were reported in the United States a few scattered cases of undulant fever as early as 1904 its clinical recognition as a common infection dates from 1926. Our present knowledge...Bibliography1. GERSHENFELDBUTTS LDC: A survey of undulant fever and Bang's disease in the United States, Am. Jr. Med. Sci., 1937, cxciv, 678-684. CrossrefGoogle Scholar2. To be published. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Kansas City, Kansas*Delivered before the American College of Physicians, New York City, April 6, 1938.From the Department of Medicine, University of Kansas Hospitals, Kansas City, Kansas.We wish to acknowledge the coöperation of Dr. W. F. Lunsford, Director of Health, Kansas City, Kansas, and Drs. Leona Baumgartner and Alice Evans, National Institute of Health. Without their assistance the collection of this material would have been impossible. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 February 1939Volume 12, Issue 8Page: 1189-1193KeywordsBrucellosisChildrenFeversHospital medicine ePublished: 1 December 2008 Issue Published: 1 February 1939 PDF downloadLoading ...
Animal experimentation: the continuing debate
Authors: Mark Matfield
Journal: Nature Reviews Drug Discovery (2002)

The use of animals in research and development has remained a subject of public debate for over a century. Although there is good evidence from opinion surveys that the public accepts the use of animals in research, they are poorly informed about the way in which it is regulated, and are increasingly concerned about laboratory-animal welfare. This article will review how public concerns about animal experimentation developed, the recent activities of animal-rights groups, and the opportunities and challenges facing the scientific community.
Self-management of Chronic Disease—Reply
Authors: John McDougall
Journal: JAMA (2003)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Abstract 13016: Tissue Mitral Annular Displacement (TMAD) Predicts Long-term Prognosis in Heart Failure Patients Receiving Cardiac Resynchronization Therapy
Authors: Katsuomi Iwakura, Atsunori Okamura, Yasushi Koyama, Motoo Date, Koichi Inoue, Hiroyuki Nagai, Yuko Toyoshima, Koji Tanaka, Takafumi Oka, Nobuaki Tanaka, Yuko Yamanaka, Tomohiro Yamasaki, Tomoaki Okada, Yohei Sotomi, Kohei Azuma, Yoshiyuki Orihara, Satoshi Kameda, Mutsumi Iwamoto, Yoshihiro Ota, Kenshi Fujii
Journal: Circulation (2014)

Introduction: Assessment of left ventricular (LV) dyssynchrony by echocardiography has only a limited ability to predict response to cardiac resynchronizing therapy (CRT) because of high variability of the measurement.Tissue mitral annular displacement (TMAD) is a rapid and robust method for the assessment of left ventricular (LV) longitudinal deformity. We previously reported that TMAD predicts good responders to CRT among patients with severe heart failure (AHA scientific meeting 2012). In the present study, we investigated whether TMAD could predict the long-term prognosis after CRT implantation. Methods: We performed echocardiography study in 41 patients with dilated cardiomyopathy (DCM) before and at 6 month of CRT, using iE33 (Philips Medical Systems). TMAD was measured on an apical 4-chamber image using QLAB software (Philips Medical Systems) to assess the movement of septal- and lateral part of mitral annulus toward apex. We measured the interval between QRS complex to peak of displacement on both regions, and calculated the differences in time-to-peak (dTTP). We defined good response to CRT as decrease in LV end-systolic volume (LVESV) &gt; 15% at 6 month of CRT. We followed the patients to observe cardiovascular events including death, myocardial infarction, stroke and hospital admission for heart failure. Results: The 27 good responders (65.8%) had significantly longer dTTP than the non-responders (156±64 vs. 63±61 msec, p&lt;0.0001). Using 104 msec as a cutoff value, TMAD detected CRT responders with sensitivity of 79% and specificity of 78% (AUC=0.83). We observed 20 cardiac events during follow-up period of 1182±635 days. We found that dTTP was significantly associated with cardiovascular events (p=0.048 by Cox proportional hazard model), and that patients with dTTP≥104ms had better prognosis than others (Figure). Conclusion: TMAD is a promising method for predicting long-term prognosis in patients with DCM receiving CRT.
The Janus kinase inhibitor JTE-052 improves skin barrier function through suppressing signal transducer and activator of transcription 3 signaling
Authors: Wataru Amano, Saeko Nakajima, Hayato Kunugi, Yasuharu Numata, Akihiko Kitoh, Gyohei Egawa, Teruki Dainichi, Tetsuya Honda, Atsushi Otsuka, Yukari Kimoto, Yasuo Yamamoto, Atsuo Tanimoto, Mutsuyoshi Matsushita, Yoshiki Miyachi, Kenji Kabashima
Journal: Journal of Allergy and Clinical Immunology (2015)
Abstract 15934: Microrna-27a Regulates Cardiomyocytic Apoptosis During Cardioplegia-Induced Cardiac Arrest Under Cardiopulmonary Bypass by Targeting Interleukin-10-Related Pathway
Authors: Chi-hsiao Yeh, Tzu-Ping Chen, Yao-Chang Wang, Yu-Min Lin, Shu-Wen Fang
Journal: Circulation (2011)

Background: MicroRNAs (miRs) had powerful and unexpected roles in numerous cardiovascular diseases. miR-based therapeutic may provide a unique opportunity to translate this knowledge into the clini...
Kneed to know
Authors: Douglas Kamerow
Journal: BMJ (2005)

One of my medical school teachers told us that God made a mistake when He (God had a gender then) designed our knees. Another said it was our own fault for walking up-right, as knees just weren't designed to take that kind of stress. The human knee is a joint that is both frequently injured and seemingly not up to the job of lasting our current extended lifetimes carrying our current excess of weight. The results: osteoarthritis, and a good part of this issue.

Non-steroidal anti-inflammatory drugs …
SARS in China
Authors: Joan Stephenson
Journal: JAMA (2004)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Genomic Profiling of Cancers of Unknown Primary Site—Reply
Authors: Jeffrey S. Ross, Vincent A. Miller, Philip J. Stephens
Journal: JAMA Oncology (2015)

Jeffrey S. Ross, MD; Kai Wang, MD, PhD; Laurie Gay, PhD; Geoff A. Otto, PhD; Emily White, BS; Kiel Iwanik, BS; Gary Palmer, MD; Roman Yelensky, PhD; Doron M. Lipson, PhD; Juliann Chmielecki, PhD; Rachel L. Erlich, PhD; Andrew N. Rankin, PhD; Siraj M. Ali, MD, PhD; Julia A. Elvin, MD, PhD; Deborah Morosini, MD; Vincent A. Miller, MD; Philip J. Stephens, PhD
643. Prolonged Expression of Human Alpha-1-Antitrypsin in C3H/Hej Mice with Helper-Dependent Adenoviral Vectors Irrespective of Tissue Distribution of Gene Expression
Authors: Akihiro Otsuki, Akihiro Kurimasa, Candice G. T. Tahimic, Motonobu Katoh, Mitsuo Oshimura
Journal: Molecular Therapy (2004)

We have recently constructed a novel HAC vector called 21ΔqHAC, generated by deletion of a distal portion of the long arm of human chromosome 21 and insertion of a loxP sequence to facilitate insertion of any desired gene construct. We intend to use this HAC vector to rescue T and B cell development and the radiosensitive phenotype in the DNA-PKcs-deficient SCID (severe combined immunodeficiency) mice. Our approach will involve introduction of 21ΔqHAC containing the DNA-PKcs gene into DNA-PKcs-deficient ES cells, differentiation of corrected ES cells into blood stem cells and transplantation of these blood stem cells into SCID mice. To evaluate the usefulness of 21ΔqHAC vector for this purpose, we first attempted in vitro studies using CHO cells (V3) exhibiting radiosensitive phenotype due to a DNA-PKcs deficiency. In this experiment, we inserted a ~21 kb doxycycline-inducible DNA-PKcs expression cassette into 21ΔqHAC vector by Cre-mediated recombination. The resulting 21ΔqHAC/DNA-PKcs construct was then introduced into the V3 cells. RT-PCR results from cells containing the 21ΔqHAC/DNA-PKcs vector showed doxycycline-dependent regulation of the DNA-PKcs gene. Furthermore, radiosensitivity assays showed significant phenotype rescue in these cells due to the production of functional DNA-PKcs protein. To our knowledge, our study is the first to report successful artificial control of gene expression by placing the multiple regulatory elements of the tetracycline system in a single expression cassette within a HAC vector. Our results also show that 21ΔqHAC is a very useful tool in the introduction of a therapeutic gene and the correction of a defective phenotype.
N-Glycans on secretory component
Authors: Amandine Mathias, Blaise Corthésy
Journal: Gut Microbes (2011)

Human beings live in symbiosis with billions of microorganisms colonizing mucosal surfaces. The understanding of the mechanisms underlying this fine-tuned intestinal balance has made significant processes during the last decades. We have recently demonstrated that the interaction of SIgA with Gram-positive bacteria is essentially based on Fab-independent, glycan-mediated recognition. Results obtained using mouse hybridoma- and colostrum-derived secretory IgA (SIgA) consistently show that N-glycans present on secretory component (SC) play a crucial role in the process. Natural coating may involve specific Gram-positive cell wall components, which may explain selective recognition at the molecular level. More widely, the existence of these complexes is involved in the modulation of intestinal epithelial cell (IEC) responses in vitro and the formation of intestinal biofilms. Thus, SIgA may act as one of the pillars in homeostatic maintenance of the microbiota in the gut, adding yet another facet to its multiple roles in the mucosal environment.
Psychiatric patients enjoy better life in community
Authors: Roger Dobson
Journal: BMJ (2000)

The move to care in the community for patients in long stay psychiatric hospitals has been a qualified success, according to the results of a five year follow up study. Psychiatric symptoms and social behavioural problems remained the same, and there was little difference in costs, but the quality of life for patients improved and they acquired community and other skills.

The patients felt freer, with fewer rules and regulations governing their lives—an average of 10 rules in the community compared with 26 in hospital wards.

The study, by the Team for the Assessment of Psychiatric Services, also …
Preclinical evaluation of an AKT inhibitor, triciribine, in combination with gemcitabine in pancreatic cancer
Authors: Teruo Yamauchi, Said Sebti, Mokenge Malafa
Journal: Clinical Cancer Research (2008)

A42  Introduction: Pancreatic cancer is a highly lethal cancer due to early metastasis and prevalent drug resistance. Abnormal AKT activation is known to be one of the mechanisms of chemoresistance to gemcitabine in pancreatic cancer. We tested the hypothesis that combining an AKT inhibitor, triciribine (TCN), to gemcitabine augments antitumor activity in vitro. Methods: Gemcitabine and TCN, alone or in combination were given to a human pancreatic cancer cell line, MIA PaCa-2 that expresses phosphorylated AKT. The effects of treatments were evaluated by trypan blue assay, MTT assay, and CellDeath ELISA. Colorimetric data of MTT assay were computationally analyzed for synergism of the combination therapy by CalcuSyn2. Results: Both gemcitabine and TCN inhibited cell growth in dose-dependent manner. TCN synergistically enhanced the cytotoxic activity of gemcitabine. Combination index at ED50 in 1:500 ratio (gemcitabine:TCN) was 0.74. The combination treatment with the non-apoptotic dose of each agent distinctly induced apoptosis. Conclusion: Gemcitabine in combination with TCN synergistically inhibits pancreatic cancer cell growth and induces apoptosis. These findings support the novel combination be tested in vivo and translated to the clinical setting.
The Prehospital Electrocardiogram in Acute Myocardial Infarction: Is Its Full Potential Being Realized? fn1fn1The National Registry of Myocardial Infarction 2 is supported by Genentech, Inc., South San Francisco, California.
Authors: John G. Canto, William J. Rogers, Laura J. Bowlby, William J. French, Douglas J. Pearce, W.Douglas Weaver
Journal: Journal of the American College of Cardiology (1997)