tbuckley/cabot-search huggingface dataset:
Selectin on activated platelets enhances neutrophil endothelial adherence in myocardial reperfusion injury
Authors: S Kogaki
Journal: Cardiovascular Research (1999)

The glycoprotein P-selectin is an adhesion molecule that is rapidly expressed on the surface of platelets and endothelium during the inflammatory process. P-selectin on endothelium has been reported to play an important role in reperfusion injury. However, little is known regarding P-selectin on platelets in contributing to the pathophysiology of myocardial reperfusion injury. In this study, we hypothesized that P-selectin on platelets may enhance neutrophil endothelial adherence and this may play a role in neutrophil-mediated reperfusion injury.Endothelial cells, cardiomyocytes, platelets and neutrophils were isolated from adult rats. Endothelial cells and cardiomyocytes were cultivated in a co-culture system. After exposure to hypoxia and reoxygenation, neutrophil adherence and migration were examined.After exposure to 6 h of hypoxia, endothelial cells co-incubated with platelets showed significantly greater neutrophil adherence (63.1 +/- 4.0%) and migration (78.2 +/- 6.7%) than endothelial cells alone (adhesion: 44.2 +/- 2.8%, migration: 57.9 +/- 4.9%). These increases were significantly inhibited (adhesion: 42.1 +/- 3.5%, migration: 65.5 +/- 3.8%) by an anti-P-selectin monoclonal antibody. Moreover, the superoxide-anion production was significantly elevated when activated platelets were added to neutrophils. This enhanced production was also inhibited by anti-P-selectin antibody.The presence of activated platelets enhanced neutrophil adhesion and migration process after hypoxia reoxygenation. This process may occur following platelet-neutrophil interactions via P-selectin and subsequent neutrophil activation.
Gout secondary to chronic renal disease: studies on urate metabolism.
Authors: L F Sorensen
Journal: Annals of the Rheumatic Diseases (1980)

Grapevines can be affected by many viruses and viral diseases. However, despite a long history of cultivation and breeding efforts, little useable resistance to viral diseases has been identified in <i>Vitis</i> species. As a result, management of viral diseases has largely relied upon prevention/exclusion or on the use of economically and/or environmentally consequential methods to manage vector populations. Resistance to dagger nematode vectors has been identified and successfully transferred to rootstock genotypes that are commercially available, but these resistant materials do not prevent virus translocation into the scion, although a significant delay in infection can allow for suitable production. In this review, we critically evaluate the literature regarding resistance against viruses and vectors in <i>Vitis</i> and <i>Muscadinia</i> species. We examine the challenges of breeding grapevines for virus resistance and the methodologies used to test for resistance. The availability of useful sources of resistance and tolerance toward both viruses and their vectors, or lack thereof, is evaluated and discussed in terms of disease management.
B-cell receptor cross-linking delays activation-induced cytidine deaminase induction and inhibits class-switch recombination to IgE
Authors: Haifa H. Jabara, Jayanta Chaudhuri, Shilpee Dutt, Fatma Dedeoglu, Yu Weng, Michael M. Murphy, Sonia Franco, Fredrick W. Alt, John Manis, Raif S. Geha
Journal: Journal of Allergy and Clinical Immunology (2007)
Cloning and characterization of β-fructofuranosidase, a newly identified glycoprotein as a minor allergen of tomato (Lycopersicon esculentum)
Authors: Sandra Westphal, Kay Foetisch, Iris Lauer, Amedeo Conti, Daniel Kolarich, Friedrich Altmann, Dieter Haustein, Stefan Vieths, Stephan Scheurer
Journal: Journal of Allergy and Clinical Immunology (2002)
Risk factors for bacteremia during and after adenoidectomy and/or adenotonsillectomy
Authors: Susanna Esposito, Paola Marchisio, Pasquale Capaccio, Marta Bellasio, Margherita Semino, Elisa Dusi, Rosaria Colombo, Lorenzo Pignataro, Nicola Principi
Journal: Journal of Infection (2009)
Medical Examiners' Fees.
Authors: Liston H. Montgomery
Journal: JAMA (1895)

Chicago, Ill., Nov. 12, 1895. <h3>To the Editor:</h3> —I perused with much gratification the instructive paper entitled, "Practical Life Insurance Examinations," by Dr. John L. Davis (Journal, September 28), and more recently enjoyed the discussion upon this topic by Dr. W. W. Vinnedge, of Lafayette, Ind., (JournalOctober 12 and 26) and, lastly, the views set forth in your editorial on this subject. One of the most important questions perhaps that arises, in my mind is this, What are Dr. Vinnedge, and all his confrères throughout the country going to do about it? Suppose the life insurance companies named (and others are likely to adopt the same course) have reduced the fee for medical examinations, shall they — these companies who have accumulated and own millions of dollars worth of assets, and in hundreds and thousands of instances have relieved the distressed and unfortunate, be boycotted? Shall abler and more
Physician Suicide-Reply
Authors: William R. Hendee
Journal: JAMA (1987)

<h3>In Reply.—</h3> Dr Dempsey is correct in assuming that "control" is not synonymous with "normal." The control group is used to compare the occurrence of risk factors in the suicide cases with that in physicians who died of causes other than suicide. Further, controls were not randomly selected; they were physicians who died between 1980 and 1984, matched by age and sex to those in the suicide group. Clearly, one cannot make inferences to the entire physician population. Dr Day's concern about the role of malpractice in physician suicide, especially among anesthesiologists, cannot be answered with data collected from this study. Both the number of malpractice suits and the number of anesthesiologists were too small to conduct meaningful analysis.
Relationship among human herpesvirus 6 reactivation, serum interleukin 10 levels, and rash/graft-versus-host disease after allogeneic stem cell transplantation
Authors: Kana Kitamura, Hideo Asada, Hideyuki Iida, Takaya Fukumoto, Nobuhiko Kobayashi, Hironori Niizeki, Takeshi Morii, Hiroshi Kimura, Sachiko Miyagawa
Journal: Journal of the American Academy of Dermatology (2008)
Psychiatric Illness and Female Criminality: The Role of Sociopathy and Hysteria in the Antisocial Woman
Authors: C. ROBERT CLONINGER, SAMUEL B. GUZE
Journal: American Journal of Psychiatry (1970)

A systematic psychiatric study was carried out with a group of convicted women felons. All the women received at least one psychiatric diagnosis. Sociopathy, alcoholism, drug dependency. hysteria, and homosexuality were encountered more frequently than would be expected in the general female population. Sociopathy or hysteria was found in 80 percent; a 20 times greater prevalence of hysteria than is found in the general population was the most striking finding. The results of this study confirm other work suggesting that there is a significant association between sociopathy and hysteria.
Pancreatic cancer therapy by systemic administration of VEGF siRNA contained in calcium phosphate/charge-conversional polymer hybrid nanoparticles
Authors: Frederico Pittella, Kanjiro Miyata, Yoshinori Maeda, Tomoya Suma, Sumiyo Watanabe, Qixian Chen, R. James Christie, Kensuke Osada, Nobuhiro Nishiyama, Kazunori Kataoka
Journal: Journal of Controlled Release (2012)
THE SUBMUCOUS RESECTION OF THE NASAL SEPTUM.WITH A REPORT OF FIFTY-SIX OPERATIONS.
Authors: J. F. BYINGTON
Journal: JAMA (1907)

The familiarity of the members of this Section with the history of the submucous resection of the septum and the principles underlying the operation enables me to devote the time allotted for this paper to an account of my personal work during the last ten months and to some practical deductions from my experience in dealing with the fifty-six cases operated on. <h3>CLASSIFICATION OF CASES.</h3> Of the fifty-six cases, forty-one were males and fifteen females. Five were between the ages of 10 and 19, eighteen between the ages of 20 and 29, seventeen between the ages of 30 and 39, twelve between the ages of 40 and 49, and four between the ages of 50 and 57. The youngest patient was 10 years of age, the oldest 57. I have followed the classification of Freer, which is based on the form of the deflection rather than on its cause. He
In Vivo Correction of Murine Tyrosinemia Type I by DNA-Mediated Transposition
Authors: Eugenio Montini, Patrice K. Held, Meenakshi Noll, Nicolas Morcinek, Muhsen Al-Dhalimy, Milton Finegold, Stephen R. Yant, Mark A. Kay, Markus Grompe
Journal: Molecular Therapy (2002)

Gene therapy applications of naked DNA constructs for genetic disorders have been limited because of lack of permanent transgene expression. This limitation, however, can be overcome by the Sleeping Beauty (SB) transposable element, which can achieve permanent transgene expression through genomic integration from plasmid DNA. To date, only one example of an in vivo gene therapy application of this system has been reported. In this report, we have further defined the activity of the SB transposon in vivo by analyzing the expression and integration of a fumarylacetoacetate hydrolase (FAH) transposon in FAH-deficient mice. In this model, stably corrected FAH(+) hepatocytes are clonally selected and stable integration events can therefore be quantified and characterized at the molecular level. Herein, we demonstrate that SB-transposon-transfected hepatocytes can support significant repopulation of the liver, resulting in long-lasting correction of the FAH-deficiency phenotype. A single, combined injection of an FAH-expressing transposon plasmid and a transposase expression construct resulted in stable FAH expression in approximately 1% of transfected hepatocytes. The average transposon copy number was determined to be approximately 1/diploid genome and expression was not silenced during serial transplantation. Molecular analysis indicated that high-efficiency DNA-mediated transposition into the mouse genome was strictly dependent on the expression of wild-type transposase.
IKK as a target for treatment of inflammation induced bone loss
Authors: M G Ruocco
Journal: Annals of the Rheumatic Diseases (2005)

The transcription factor nuclear factor (NF)-kappaB is well recognised as a pivotal player in osteoclastogenesis and inflammation induced bone loss. Here, the authors discuss their recent results, obtained using a genetic approach in mice, that indicate the importance of IKKbeta, and not IKKalpha, as a transducer of signals from receptor activator of NF-kappaB (RANK) to NF-kappaB. Ablation of IKKbeta results in lack of osteoclastogenesis and unresponsiveness of IKKbeta deficient mice to inflammation induced bone loss. In the need of a more effective therapy for the treatment of inflammatory diseases causing bone resorption, specific inhibition of IKKbeta represents a logical alternative strategy to the current therapies.
Diphenylhydantoin Intoxication Mimicking Botulism
Authors: Martin Wand, John A. Mather
Journal: New England Journal of Medicine (1972)

THE illicit use of drugs has become a major national problem. Often, the user has no knowledge of the pharmacologic actions of the drug, and, sometimes, he may not even know the type of drug he is taking.1 Frequently, the imputed drug may actually be, in part or in whole, a completely different compound.2 Recently, two patients were treated for botulism that proved to be intoxication due to cliphenylhydantoin-adulterated marijuana.Case ReportsTwo 22-year-old men were admitted to the hospital with the diagnosis of botulism. Three hours after having a lunch of home-canned corn, they felt "lightheaded" and weak. By . . .
Pseudoachondroplasia is caused through both intra- and extracellular pathogenic pathways
Authors: Robert Dinser, Frank Zaucke, Florian Kreppel, Kjell Hultenby, Stefan Kochanek, Mats Paulsson, Patrik Maurer
Journal: Journal of Clinical Investigation (2002)

Pseudoachondroplasia is a dominantly inherited chondrodysplasia associated with mutations in cartilage oligomeric matrix protein (COMP). Investigations into the pathogenesis of pseudoachondroplasia are hampered by its rarity. We developed a cell culture model by expressing mutant COMP in bovine primary chondrocytes using a gutless adenoviral vector. We show that mutant COMP exerts its deleterious effects through both intra- and extracellular pathogenic pathways. Overexpression of mutant COMP led to a dose-dependent decrease in cellular viability. The secretion of mutant COMP was markedly delayed, presumably due to a prolonged association with chaperones in the endoplasmic reticulum (ER). The ECM lacked organized collagen fibers and showed amorphous aggregates formed by mutant COMP. Thus, pseudoachondroplasia appears to be an ER storage disease, most likely caused by improper folding of mutant COMP. The growth failure of affected patients may be explained by an increased cell death of growth-plate chondrocytes. Dominant interference of the mutant protein on collagen fiber assembly could contribute to the observed failure of the ECM of cartilage and tendons.
An evaluation of the gastroduodenal fibrescope
Authors: W. Burnett
Journal: Gut (1962)

One hundred and sixty patients have been examined with the flexible gastroduodenoscope. Passage of this instrument is easier than of the conventional gastroscope, and the stomach can be examined down to the pyloric canal and pylorus. Duodenoscopy is sometimes possible but some modification is required in order to guarantee success. Examination of a gastrojejunal stoma is practically always possible and is superior to that obtained with the gastroscope. The fibrescope can be used in patients with haematemesis within a few hours of their admission to hospital, and with it definitive early diagnosis is possible in two out of three patients.
Papillotomy and Functional Disorders of the Sphincter of Oddi
Authors: P.E. Krims, P.B. Cotton
Journal: Endoscopy (1988)

The term “functional” as applied to disorders of the sphincter of Oddi is indefinite since it encompasses a spectrum of disorders from histopathologic fibrosis of the sphincter to sphincteric dysfunction without evident pathologic transformation. Although there are several approaches to the diagnosis of sphincter of Oddi dysfunction, the diagnosis still depends on the exclusion of other causes of obstruction. Reports of surgical sphincteroplasty in patients with this diagnosis suggest that the outcome is unpredictable. Operative mortality ranges from 0.6 % to 6.0 % and morbidity from 3.3 % to 18 %. Operative sphincteroplasty appears to have no adverse sequelae long-term, although there are few reports of extended follow-up. In our experience, about 10 % of patients undergoing endoscopic sphincterotomy for calculi have recurrent biliary problems during extended follow-up, but most problems were not formidable. In large series of patients undergoing endoscopic sphincterotomy, papillary stenosis is the indication for the procedure in about 5 % of cases. With this indication, immediate complications occur with greater frequency compared to endoscopic sphincterotomy for choledocholithiasis. The validity of every proposed test for sphincter dysfunction and/or stenosis has been challenged, and the diagnosis must still be considered imprecise. This fundamental problem makes it difficult to interpret the results of endoscopic sphincterotomy. It also necessitates a cautious approach to management of this disorder by endoscopic sphincterotomy. Other methods of sphincter manipulation such as endoscopic balloon dilation have not been studied extensively. Although endoscopic sphincter-otomy has been performed in a few patients with idiopathic recurrent pancreatitis, the procedure must be considered experimental in this group of patients.
NICE proposals for citizens council condemned by patients
Authors: A. Gulland
Journal: BMJ (2002)

A “citizens council” announced last week by the National Institute for Clinical Excellence (NICE) to advise on decision making has been attacked as a “toothless tiger” by patients.

The council will be made up of 30 members of the public who will be paid £150 ($231;€235) a day to consider “generic” issues. The council, which will act in an advisory capacity, will meet for three days twice a year and will not have any input into decisions on individual treatments.

Mike Stone, chief executive of the Patients Association, said that setting up …
Abstract 1733: Development of a novel blood plasma protein test for diagnosis of lung cancer
Authors: Robert T. Streeper, Elzbieta Izbicka, Armando Diaz, David Campos, Christopher Louden, Joel Michalek
Journal: Cancer Research (2012)

Abstract Background: A blood test for detection of lung cancer (LC) could provide survival benefits in high-risk populations. We conducted a retrospective study as the next step of our effort to develop a test for diagnosis of non-small cell lung carcinoma (NSCLC), the most common form of LC, by measuring levels of protein biomarkers in plasma. Materials and Methods: We quantified levels of 106 proteinaceous biomarkers using multiplexed immunoassays of subjects a) diagnosed with stage I/II NSCLC, b) normal non-smoking controls, and c) normal heavy smoking controls (&amp;gt; 10 p.y.). All groups consisted of Caucasian men and women (93 subjects each, ages range 45-87, Ave 59). The specimens were randomized and tested in a blinded manner. A support vector machine (SVM) algorithm, developed and tested in a pilot study, was used to identify differentially expressed biomarkers in the disease and control groups taking into account patients’ gender. Pathway analysis was applied to characterize pathology- and gender-specific patterns of biomarker expression. Results: In a recent pilot study we developed SVM models that classified subjects to NSCLC or normal using 59 plasma markers or subsets thereof, for both genders combined or separately. When data for both genders were analyzed together, SVM classified subjects to NSCLC or normal and identified 4 differentially expressed markers: EGF, sCD40 ligand, IL-8 and MMP-8; sensitivity (SE) 0.93 (95% CI: 0.88-0.96), specificity (SP) 0.87 (95% CI: 0.80-0.92). Considering the sexes separately, the differentially expressed best subset of markers for men (EGF, IL-8, sFAS, MMP-9 and PAI-1) had both SE and SP of 1.0. For women, the best subset of markers (EGF, sCD40 ligand and IL-8) also yielded SE and SP of 1.0. The present study has further confirmed and refined our earlier findings and expanded panels of diagnostic biomarkers for NSCLC with comparable sensitivities and specificities. Analysis of cellular pathways represented by the discriminatory biomarker signatures suggested a role of sex hormone-driven differences of NSCLC plasma biomarkers. Conclusions: The set of diagnostic biomarkers for NSCLC identified in this study holds significant promise for use in the early diagnosis of lung cancer and warrants validation of findings in other ethnic groups and for potentially confounding diseases in clinical studies. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 103rd Annual Meeting of the American Association for Cancer Research; 2012 Mar 31-Apr 4; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2012;72(8 Suppl):Abstract nr 1733. doi:1538-7445.AM2012-1733
Immunotherapy for Congenital Cytomegalovirus Infection
Authors: Patrick Duff
Journal: New England Journal of Medicine (2005)

Cytomegalovirus (CMV) is an extremely important perinatal pathogen. Each year, approximately 1 percent of susceptible women seroconvert during pregnancy. Although sexual transmission of CMV can occur, most pregnant women acquire CMV infection through exposure to children in their own home or from occupational exposure to children in day care or elementary school. Exposure typically occurs as a result of contact with contaminated saliva, urine, or fomites such as toys. Approximately 40 percent of pregnant women with a primary infection transmit CMV to their fetuses. Rates of transmission are highest when maternal infection occurs in the third trimester; however, the risk . . .
CD-NP, A NOVEL PEPTIDE DESIGNED TO ACTIVATE BOTH GUANYLYL CYCLASE B AND A, ACTIVATES THE SECOND MESSENGER CGMP, SUPPRESSES ALDOSTERONE AND PRESERVES GFR WITHOUT REDUCING BLOOD PRESSURE IN A PROOF-OF-CONCEPT STUDY IN PATIENTS WITH CHRONIC HEART FAILURE
Authors: Elizabeth Costello, John A. Schirger, Guido Boerrigter, Horng H. Chen, Ruth Kempf, Candace Y. Lee, John C. Burnett
Journal: Journal of the American College of Cardiology (2011)
Arachnoid nodules in the lungs of high altitude Indians.
Authors: D Heath, D Williams
Journal: Thorax (1993)

BACKGROUND--Nodules of cells showing a striking histological similarity to those of arachnoid villi have previously been found closely adjacent to pulmonary venules in several diseases associated with alveolar hypoxia or pulmonary oedema including mitral stenosis, plexogenic pulmonary arteriopathy, pulmonary thromboembolism, and chronic obstructive pulmonary disease. METHODS--Histological sections of the lungs of seven adult native highlanders from La Paz (3600 m) were examined. RESULTS--Arachnoid nodules were found in the lungs of one Aymara and one Mestizo Indian. CONCLUSIONS--These bodies may have a similar function to that of arachnoid granulations which transfer excess cerebrospinal fluid to the dural venous sinuses. In the native highlanders it is possible that they contribute to the avoidance of excessive hydration of the interstitial tissue of the alveolar walls with return of fluid into the pulmonary venules, preventing incipient pulmonary oedema.
Obstetrician accused of changing notes
Authors: C. Dyer
Journal: BMJ (1997)

A deputy High Court judge last week accused an obstetrician and a midwifery sister of changing their notes and giving misleading evidence after the birth of a boy who was left profoundly disabled with cerebral palsy.

Delivering judgment at the High Court in London, the judge, John Crowley QC, dismissed evidence by consultant obstetrician Edgar Tatford, now retired from the NHS, that he had advised Francesca Brock-Hollinshead to go immediately to …
Sugar and ischaemic heart disease.
Authors: J Yudkin, R H Watson
Journal: BMJ (1969)

MBEICAOHOin one patient in whom serial biopsies showed disappearance of interlobular fibrosis and lobular distortion over a six-year period.Nevertheless, an underlying macronodular cirrhosis may be difficult to exclude in the small specimens obtained by needle biopsy.Of particular interest are the two patients of Weintraub, Conrad, and Crosby3 in whom the initial biopsy showed definite nodular regeneration with broad bands of fibrosis.At the end of venesection therapy the appearances were similar except that the iron had been removed, whereas eight years later, after the patients had been mantained on intermittent venesections, lobular architecture was normal with minimal fibrosis only.Pirart' reported similar findings in a 47-year-old non- alcoholic patient with haemochromatosis.After removal of 48 litres of blood over a two-year period the liver was free of iron though fibrosis remained.Three years later a further biopsy showed disappearance of the fibrosis."
The Health Care of Hispanics-Reply
Authors: Eli Ginzberg
Journal: JAMA (1991)

ABSTRACT In Reply.— I have some (but not a whole lot of) sympathy for Dr Eichberg's reactions to the use of the term Hispanic in the January 9,1991, issue of JAMA. My fellow contributors and I were careful to use subaggregated categories whenever the data permitted. My own analyses differentiated clearly among Mexican Americans, Puerto Ricans, and Cubans.Dr Eichberg is right when he questions the scientific basis for using the term Hispanic as a significant category, but in my simple view Hispanic patients share a common language and often a common culture, and, to some degree, they may even have a common genetic inheritance.I agree with Dr Manson's suggestion that Spanish-speaking patients should be able to communicate directly or through an interpreter with physicians who are treating them.