JAUNDICE, HYPERLIPEMIA AND HEMOLYTIC ANEMIA: A HERETOFORE UNRECOGNIZED SYNDROME ASSOCIATED WITH ALCOHOLIC FATTY LIVER AND CIRRHOSIS
Authors: L ZIEVE
Journal: Annals of Internal Medicine (1958)

Article1 March 1958JAUNDICE, HYPERLIPEMIA AND HEMOLYTIC ANEMIA: A HERETOFORE UNRECOGNIZED SYNDROME ASSOCIATED WITH ALCOHOLIC FATTY LIVER AND CIRRHOSISLESLIE ZIEVE, M.D.LESLIE ZIEVE, M.D.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-48-3-471 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe data to be presented were derived from 20 patients seen at the Minneapolis Veterans Hospital over the last eight years. The symptom complex, findings and predictable course were so strikingly similar one could not escape the conclusion that they comprised a definite syndrome. However, the data were assembled largely retrospectively from records made by physicians unaware of the correlated changes taking place, so they are of necessity incomplete and spotty in individual cases. Nevertheless, in the aggregate the characteristics of the syndrome seem fairly clear.SEQUENCE OF CHANGES IN INDIVIDUAL PATIENTSThe sequence of changes in individual patients best...Bibliography1. ChaplinMollison HPL: Red cell life-span in nephritis and in hepatic cirrhosis, Clin. Sc. 12: 351, 1953. MedlineGoogle Scholar2. Feigl J: Neue Untersuchungen zur Chemie des Blutes bei akuter Alkoholintoxikation und bei chronischen Alkoholismus mit besonderer Berucksichtigung der Fette und Lipoide, Biochem. Ztschr. 92: 282, 1918. Google Scholar3. HollettMeng CHC: Comparison of fat emulsion clearing activities of postheparin plasma and pancreatic lipase, Am. J. Physiol. 184: 428, 1956. CrossrefMedlineGoogle Scholar4. HymanSouthworth GHH: Hemolytic anemia associated with liver disease, Am. J. M. Sc. 221: 448, 1951. CrossrefMedlineGoogle Scholar5. Jandl J: The anemia of liver disease: observations on its mechanism, J. Clin. Investigation 34: 390, 1955. CrossrefMedlineGoogle Scholar6. 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Derivation of a correction allowing use of the bromsulfalein test in jaundiced patients, J. Lab. and Clin. Med. 37: 40, 1951. MedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Minneapolis, Minnesota*Presented at the Thirty-eighth Annual Session of The American College of Physicians, Boston, Massachusetts, April 12, 1957.From the Department of Medicine and the Radioisotope Service, Veterans Administration Hospital and University of Minnesota, Minneapolis, Minnesota.Requests for reprints should be addressed to Leslie Zieve, M.D., Veterans Administration Hospital, Fifty-fourth Street and Forty-eighth Avenue, South, Minneapolis 17, Minnesota. 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GREENBERG, M.D., WILLIAM C. BLACKWELDER, Ph.D., ROBERT I. LEVY, M.D.Hematologic and oncologic implications of alcoholismBiochemical Tests for Hepatobiliary DiseaseRed Cell Metabolic and Membrane Features in Haemolytic Anaemia of Alcoholic Liver Disease (Zieve's Syndrome)Coronary artery occlusion and alcohol intake.Alcohol Consumption and HematologyUntersuchungen zur Pathogenese alkoholinduzierter Stoffwechsel- und Membrandefekte roter Blutzellen bei LebererkrankungenMetabolic Effects of Alcohol on the Blood and Bone MarrowVer�nderungen in den Membranlipiden der Erythrocyten bei �thanolinduzierter Hyperlipid�mie (Zieve-Syndrom)Hemolytic Anemias: Failure of the Red Cell MembraneDie äthanolinduzierte Hyperlipoproteinämie des stoffwechselgesunden MenschenAlteration of plasma lipids and intermediates of lipid metabolism in healthy fasting volunteers by ethanol and fructoseSerum Lipids in AlcoholicsHyperlipoproteinämie Typ IVAlcoholic HyperlipemiaStoffwechsel und Membranlipide roter Blutzellen bei alkoholtoxischer Fettleber und HyperlipoproteinämieTime-dependent reaction of human red cell deformability on sphering agentsMorphologische Befunde bei ZIEVE-SyndromThe Relationship of Red Cell Membrane Lipid Content to Red Cell Morphology and Survival in Patients with Liver Disease*ALCOHOL AND HEMATOPOIESISMembrane Structure and its Relation to HaemolysisRed Cell Metabolism in Transient Haemolytic Anaemia Associated with Zieve's SyndromeHemolysis, Jaundice and Liver DiseaseKlinische und experimentelle Untersuchungen bei alkoholinduzierten Hyperlipoproteinämien und Zieve-SyndromTherapy of Alcoholic Liver Disease**Supported in part by the Stratfield Fund.Ethanol Inhibition of Haemoglobin Synthesis: In Vitro Evidence for a Haem Correctable Defect in Normal Subjects and in AlcoholicsModerate Ethanol Ingestion and Plasma Triglyceride Levels A Study in Normal and Hypertriglyceridemic PersonsHENRY GINSBERG, M.D., JERROLD OLEFSKY, M.D., JOHN W. 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EFFECTS ON PARAMETERS OF LIVER FUNCTION, PLASMA LIPID CONCENTRATIONS AND LIPOPROTEIN PATTERNSBlutThe Study of the Postoperative transfusion HepatitisEthanol metabolism and uric acidReferencesNutritional aspects of alcohol consumptionCLINICAL AND METABOLIC STUDY OF ALCOHOLIC HYPERLIPIDÆMIAHemolysis and Changes in Erythrocyte Membrane LipidsTransient Intravascular Haemolysis Associated with Alcoholic Liver Disease and Hyperlipidaemia**Mechanisms of Hemolysis — The Minimal Red-Cell DefectStudies on the lipids of Plasmodium knowlesi -infected rhesus monkeys ( Macaca mulatto )A Clinical Approach to the HyperlipidemiasChronic PancreatitisWILLIAMSON B. STRUM, M.D., HOWARD M. SPIRO, M.D.Die Wirkung des Äthylalkohols auf die Plasmalipide isocalorisch ernährter VersuchspersonenThe evolution of anemia in alcoholic patientsMORE MALADIES IN MEDITERRANEAN MIGRANTS STOMATOCYTOSIS AND MACROTHROMBOCYTOPENIALACTATE DEHYDROGENASE ISOENZYME PATTERNS IN SERUM AND SKELETAL MUSCLE IN INTOXICATED ALCOHOLICSThrombocytopenia of Severe AlcoholismDALE H. COWAN, M.D., JOHN D. HINES, M.D.Acute and Chronic Toxicity of AlcoholEffects of Ethanol on Lipid, Uric Acid, Intermediary, and Drug Metabolism, Including the Pathogenesis of the Alcoholic Fatty LiverII. 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TWOMEY, M.B., F.A.C.P.Cytochemie des Nichthämoglobineisens der Erythrocyten nach Splenektomie und bei MilzinsuffizienzAlkohol und BlutAlcohol-induced liver damageAlcohol-induced liver damageOCCULT BLOOD IN FÆCESALCOHOL AND THE BLOODZur diagnostischen Bedeutung der Haptoglobin-Hämoglobin-Bindungskapazität, Erythro- und Ferrokinetik bei chronischen LeberschädenAlcoholic Fatty LiverAbnormal pattern of the phospholipids of plasma and erythrocytes in four children with obstructive jaundice with abnormal spontaneous hemolysisThe Differential Diagnosis of JaundiceAnabolic steroid therapy as an adjunct to diet in alcoholic hepatic steatosisReversibility of the erythrocyte lipid abnormalities in hepatic diseaseBurr cells, hemolytic anemia and cirrhosisVariations des lysolécithines sanguines dans la néphroanémie du nourrissonThrombocytopenia and AlcoholismROBERT M. POST, M.D., JANE F. DESFORGES, M.D.Thrombocytopenia in AlcoholicsJOHN LINDENBAUM, M.D., R. LESLIE HARGROVE, M.D.Plasma Lipoproteins in the Differential Diagnosis of Liver DiseaseALCOHOLIC HYPERLIPAEMIAClinical applicability of urea-LDH test in various pyruvate concentrationsA new hereditary acanthocytosis syndromeSOME CLINICAL AND CHEMICAL MANIFESTATIONS OF ALCOHOL-INDUCED HYPERLIPAEMIAFat Transport in Lipoproteins — An Integrated Approach to Mechanisms and DisordersÜber das Zieve-SyndromLipoprotein TransportLipoprotein TransportDigestive SystemEthanol and Liver DiseaseSpur-Shaped Erythrocytes in Laennec's CirrhosisTHE EFFECTS OF ALCOHOL ON THE GASTRO‐INTESTINAL TRACTThe relation of hyperlipemia to hemolytic anemia in an alcoholic patientEffect of ethanol on lipoprotein lipase activityHepatic and Metabolic Effects of AlcoholIntroduction—a perspectiveEnergy storageRelative importance of different tissues in the synthesis of fatty acidsComparative anatomy of adipose tissue 1Adipose tissue in migratory birdsMetabolic pathways in the insect fat body 1Fat metabolism in fishThe physiological role of brown adipose tissue 1The development of adipose tissueHistogenesis 1The fine structure of adipose tissuesMorphology of adipose tissue: a microscopic anatomy of fatPathological anatomy of adipose tissue 1Lipid components of adipose tissueFatty substances containing ether linkagesFatty acid patterns in human adipose tissueStructural sugars in adipose tissueDistribution of adrenergic nerve fibers in brown and white adipose tissueStructural aspects of adipose tissue: A summary attempting to synthesize the information contained in the preceding chaptersFatty acid synthesis in adipose tissueTriglyceride metabolismEnzymes involved in carbohydrate metabolism in adipose tissueGlyceride biosynthesis, glyceride breakdown and glycogen breakdown in adipose tissue: mechanisms and regulationPathways of glucose metabolismPathways of glucose metabolism IIFructose metabolism in adipose tissue from normal and diabetic rats 1The clearing factor lipase activity of adipose tissueAdipose tissue lipases IIHormone‐sensitive lipolytic activity of adipose tissue 1Glycogen metabolism in adipose tissueAdipose tissue in diabetesRegulation of fatty acid release with particular reference to pituitary factorsRelease of free fatty acids from adipose tissue in vitro in relation to rates of triglyceride synthesis and degradationLipid peroxidation 1Net gas exchange and oxygen consumptionConversion of amino acids to fatty acidsAmino acid and protein metabolism 1Regulation of fatty acid esterification in adipose tissue incubated in vitroEffect of feeding on fatty acid synthesis 1Effects of aging on the composition and metabolism of adipose tissue in the ratEffect of biologically active peptides on adipose tissueComparative physiology of adipose tissue in different sites and in different speciesSelective labeling of adipose tissue in vivoPerfusion of isolated adipose tissue: FFA release and blood flow in rat parametrial fat bodyMetabolism of human adipose tissue in vitroThe metabolism of isolated fat cellsMetabolism of isolated adipose tissue: a summaryChylomicron metabolism: uptake and metabolism by perfused adipose tissue 1Metabolism of lipids in chylomicrons and very low‐density lipoproteinsParticulate lipid components in plasmaEffect of dietary and endocrine factors on adipose tissue growth 1The pituitary gland and the mobilization of fatThe adipokinetic property of hypophyseal peptides and catecholamines: a problem in comparative endocrinology 1In vivo and in vitro adipokinetic effects of corticotropin and related peptides 1Lipid‐mobilizing activity during fastingInhibition of lipid mobilizationAutonomic nervous system and adipose tissueAutonomic nervous system and adipose tissueAction of lipomobilizing hormones on adipose tissuePsychogenic effects on lipid mobilizationAdipositySome physiological and clinical implications of lipid mobilization from adipose tissue 1Metabolism of adipose tissue in experimental obesityThe measurement of human adipose tissue massLipid composition and metabolism of subcutaneous adipose tissue and lipoma of manLipodystrophyEffect of adipose tissue extracts on the insulin activity of human serumBibliographySUBCLINICAL ACUTE LIVER DISEASE OF THE ALCOHOLICALCOHOL‐DEPENDENT HYPERLIPÆMIA: A REPORT OF A CASE AND A DISCUSSION OF THE POSSIBLE MECHANISMSEffect of Prolonged Ethanol Ingestion on the Transport and Metabolism of Lipids in ManDas h�molytische Syndrom bei der akuten und chronischen HepatitisAlcohol and the LiverAnatomic lesions in rats fed high fat dietsEFFECT OF TOLBUTAMIDE IN CLEARING INDUCED ALIMENTARY LIPÆMIA AFTER ALCOHOLIC HEPATOPANCREATIC DAMAGESpur-Cell AnemiaUnconjugated hyperbilirubinemia in the absence of overt hemolysisThe Role of Lysophosphatides and Fatty Acids in HaemolysisMetabolic Effects of Alcohol on the LiverAbnormal Leukocyte Response in AlcoholismWILLIAM MCFARLAND, M.D., F.A.C.P., EUGENE P. 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