tbuckley/cabot-search huggingface dataset:
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Authors: Patrick Starlinger, Mickael Lesurtel, Christine Brostjan, Pierre‐Alain Clavien, Thomas Gruenberger
Journal: Hepatology (2014)

Potential conflict of interest: Nothing to report. We want to thank Dr. Pang et al. for their interest and important remarks regarding our article. In our recently published investigation we reported intraplatelet (IP) 5‐hydroxytryptamine (5‐HT) levels to predict postoperative liver dysfunction and morbidity in patients undergoing liver resection. Based on its striking association with clinical outcome after partial hepatectomy, we thus proposed that IP 5‐HT might represent a therapeutic target to accelerate liver regeneration after liver resection.1 It should be stressed that we did not evaluate the effects of IP 5‐HT on tumor development or progression or its effects on viral hepatitis. Pang et al. point to a relevant issue with the potential use of 5‐HT which may appear like a double‐edged sword for the liver, as also recently discussed by Lesurtel et al. in more detail.2 We agree with Pang et al. that further research is required to determine whether perioperative modification of IP 5‐HT levels is of overall benefit in patients undergoing liver resection and that the following aspects should be considered. First, the adverse effects of 5‐HT pointed out by Pang et al. have only been described in animal or cell culture experiments and need to be confirmed in humans. Second, these detrimental effects might be associated with long‐term exposure to 5‐HT, while we are hypothesizing that short‐term perioperative manipulation of IP 5‐HT levels may be beneficial after hepatectomy. The therapeutic window to increase IP 5‐HT may be of crucial importance. Based on our data, the most reasonable approach of interfering with IP 5‐HT levels to support liver regeneration would presumably be a short‐term elevation prior to liver surgery as well as within the first postoperative week. This therapeutic setting will have to be evaluated with respect to potential deleterious effects on the underlying liver disease. In this context, Nozaki et al.3 documented that the controlled increase of platelets (and therefore presumably available 5‐HT) using thrombopoietin had no proliferative effect on hepatocellular carcinoma in vitro or in vivo. This finding supports the notion that a temporary, perioperative increase of platelet counts, and concomitantly 5‐HT, might have limited adverse effects on liver cancer. Most important, it should be stated that postoperative liver failure is frequently a fatal complication after liver resection.4 As specific therapeutic options to accelerate liver regeneration are missing to date, we would strongly argue for evaluating 5‐HT as a therapeutic target. A careful definition of treatment indications and therapeutic timing may be key to promote liver regeneration without inducing potential deleterious effects.
Abstract 15931: Murine Strain-Related Genetic Modifier of Endothelial Function Maps to Novel Locus
Authors: Hui Wang, Miina K Öhman, Wei Luo, Stephanie L Wolffe, Chiao Guo, Daniel T Eitzman
Journal: Circulation (2011)

Background: Endothelial dysfunction precedes the development of atherosclerosis. While dietary factors, hypertension, and smoking are associated with endothelial dysfunction, genetic determinants o...
Reed-Sternberg Cells of Classical Hodgkin's Disease React With the Plasma Cell-Specific Monoclonal Antibody B-B4 and Express Human Syndecan-1
Authors: Antonino Carbone, Annunziata Gloghini, Valter Gattei, Massimo Degan, Salvatore Improta, Donatella Aldinucci, Vincenzo Canzonieri, Tiziana Perin, Rachele Volpe, Gianluca Gaidano, Vittorina Zagonel, Antonio Pinto
Journal: Blood (1997)
Abstract 2569: Tissue Doppler Imaging In The Evaluation Of Infarcted Segmental Myocardial Function In Stemi Reperfused Patients: Correlation With Myocardial Blush Grade.
Authors: Elena Inches, Massimo Mancone, Gennaro Sardella, Raffaele Scardala, Riccardo Colantonio, Bruno Brasolin, Carmen Caira, Francesco Fedele
Journal: Circulation (2007)

Background: The myocardial blush grade (MBG) during primary-PCI predicts long-term recovery of left ventricular function. Tissue Doppler imaging (TDI) quantitatively assess regional myocardial function by measuring systolic strain (SS). No data are available on the correlation between MBG and the infarcted segmental systolic function by TDI in STEMIpts. Methods: We evaluated 40 STEMI pts, divided in four groups (MBG 0; MBG 1; MBG 2; MBG 3) 10 pts for each goup. Primary PCI was performed according to current standard guidelines. Coronary angiograms were analyzed off-line by two expert interventional cardiologists in a blinded manner. MBG were estimated visually. Sixteen-segments model was applied and regional myocardial function was evaluated, immediately after primary PCI, by measuring SS by TDI . Only SS value in infarcted segments was correlated with the MBG. Results: No significative difference was observed between groups except for family history of CAD that was higher in MBG 2 group. Mean ejection fraction (39,1 ± 8,8%) and mean symptoms to balloon time(4.3 ± 1.6 h ) was similar in the population. 136 infarcted segments were studied by TDI. A significant direct correlation between the MBG and the SS (r=0.79; p&lt;0.005) (Fig.1 ). We also observed a significative difference (p&lt;0.005) between mean SS in pts with MBG ≤0 –1 (7.6 ± 2.4%) and in pts with MBG≥2–3(22.6 ± 5.2). Conclusions: Abnormal values of SS was observed in infarcted segments. The significant correlation observed between the MBG and SS may demonstrate that MBG represent an important predictive index not only of good reperfusion but also of rapid segmental function recovery; similarly an evaluation of SS after primary PCI could be useful to evaluate if primary percutaneus reperfusion has been effective or not.
Phase I study of frequent low-dose administration of decitabine, alone or in combination with hyperCVAD, in relapsed or refractory acute lymphocytic leukemia (ALL)
Authors: H. Yang, D. A. Thomas, M. E. Rytting, P. A. Zweidler-McKay, D. L. Brown, H. Kantarjian, G. Garcia-Manero
Journal: Journal of Clinical Oncology (2007)

7072 Background: Aberrant DNA methylation is frequent in ALL. Decitabine, a hypomethylating agent, is a potent inducer of apoptosis in lymphoid leukemia cell lines. In vivo, treatment with decitabine results in transient induction of global hypomethylation. Therefore, a more frequent schedule of administration (i.e. every other week (QOW)) may have significant clinical activity. Methods: We have developed a phase I study of low decitabine administered QOW. Patients that do not respond or progress after decitabine can receive the combination of decitabine with hyperCVAD in a sequential phase of the study. Starting doses of decitabine are 10 mg/m 2 IV daily×5 every other week, and 5 mg/m 2 IV daily×5 concomitant with hyperCVAD. The studies follow a classic “3+3” design. Patients with relapsed/refractory ALL of any age are elegible. Molecular studies include the analysis of global and gene specific DNA methylation and gene expression reactivation. Results: Seven patients have been treated (median age 25, range 8–44). All had refractory disease and had previously completed at least 8 courses of hyperCVAD therapy and 2 years of maintenance therapy or similar. Four patients have been treated at dose level 1 of single agent decitabine, and 3 at dose level 2 (20 mg/m 2 ). Three of these patients have also been treated at dose level 1 of the combination of hyperCVAD and decitabine. No severe drug related toxicites have been observed. Four patients had achieved a response: 1 CR after decitabine and hyperCVAD, and 3 PR (normalization of peripheral blood with bone marrow blasts reduction of more than 50% but above 5%). One PR was achieved after decitabine and hyperCVAD, but two with only decitabine. Two of these patients did not qualify for CR because bone marrow blasts were 6%. Of these four responding patients, 1 in CR received successful alloSCT, 1 progressed after 2 courses of single agent decitabine, and 2 pediatric patients continue on therapy. The study continues. Molecular studies are ongoing. Conclusions: In summary, frequent administration of low dose decitabine, alone or in combination with hyperCVAD, may be clinically safe and active in advanced relapsed/refractory ALL. No significant financial relationships to disclose.
Coronary stent implantation is superior to balloon angioplasty for chronic coronary occlusions
Authors: Paolo Rubartelli, Edoardo Verna, Luigi Niccoli, Corinna Giachero, Marco Zimarino, Guglielmo Bernardi, Corrado Vassanelli, Luigi Campolo, Eugenio Martuscelli
Journal: Journal of the American College of Cardiology (2003)
Diphtheria Acquired by U.S. Citizens in the Russian Federation and Ukraine—1994
Authors: Vuopio-Varkila J, Ölander R-M, Valtonen, Crooks R, Stewart C
Journal: JAMA (1995)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Application of a time-varying covariate model to the analysis of CA 19–9 as a biomarker for time-to-progression (TTP) and overall survival (OS) in patients with advanced pancreatic cancer
Authors: S. Boeck, R. P. Laubender, M. Haas, C. Klose, F. Kullmann, H. Buchner, C. J. Bruns, P. Stieber, U. Mansmann, V. Heinemann
Journal: Journal of Clinical Oncology (2009)

e15545 Background: It remains unclear whether baseline CA 19–9 or CA 19–9 kinetics during chemotherapy may serve as predictive biomarker in patients (pts) with pancreatic cancer (PC). Methods: Main inclusion criteria for this retrospective multicenter analysis: histologically confirmed diagnosis of PC, treatment with first-line therapy, pre-treatment CA 19–9 level of &gt; 5.2 U/ml. Analysis of CA 19–9 was exclusively performed using the Elecsys® assay (Roche Diagnostics). The effect of the pre- treatment CA 19–9 level on TTP and OS was modelled by Cox proportional hazards regression. The effect of CA 19–9 kinetics was also modelled by Cox proportional hazards regression where CA 19–9 was treated as time-varying covariate. When modelling CA 19–9 we developed univariate and multivariate Cox models where we selected additional predictors (e.g. performance status) using backward elimination performing likelihood ratio tests on a significance level of 0.05. Results: One-hundred and fifteen pts from 5 German centers were included. Median age was 63 years, 12% had locally advanced and 88% metastatic disease; 73 % of the pts were treated within prospective clinical trials. Median baseline CA 19–9 was 1059 U/ml (range 9.5–100000), median pre- treatment bilirubin 0.6 mg/dl. The median TTP in the study population was 4.4 months, median OS 9.4 months. Univariate analysis showed that the pre-treatment CA 19–9 level (as continuous variable, log [CA 19–9]) was significantly associated with TTP (HR 1.24, 95% CI 1.12–1.37, p&lt;0.001) and OS (HR 1.16, 95% CI 1.06–1.28, p=0.002). These associations remained significant also within a multivariate analysis. For CA 19–9 kinetics during chemotherapy, data from 69 pts (TTP) and 84 pts (OS) were available, respectively; log [CA 19–9] kinetics were found to be a significant predictor for TTP in univariate (HR 1.44, 95% CI 1.25–1.67, p&lt;0.001) and multivariate (HR 1.39, 95% CI 1.19–1.62, p&lt;0.001) analyses, and also for OS (univariate: HR 1.34, 95% CI 1.20–1.49, p&lt;0.001; multivariate: HR 1.39, 95% CI 1.23–1.57, p&lt;0.001). Conclusions: According to this new statistical model, CA 19–9 may serve as a useful predictive biomarker in advanced PC. [Table: see text]
Glycoproteins: Their Biochemistry, Biology and Role in Human Disease
Authors: Robert G. Spiro
Journal: New England Journal of Medicine (1969)

A GREAT number of the proteins that are found in nature have carbohydrate covalently linked to the peptide portion and are accordingly termed glycoproteins. These conjugated proteins are represented by many substances of biologic importance, including enzymes, hormones, antibodies and membranes. The collagens, major structural proteins of the body, have now been clearly shown to belong to the glycoprotein family, and the presence of a large number of carbohydrate-containing proteins in plasma and mucous secretions has been appreciated for a long time.Increasing attention has been called to the medical importance of the glycoproteins, for they have been implicated, either . . .
Abstract 847: Trans-Resveratrol Protects Against Adriamycin-Induced Cardiomyopathy and Improves Survival
Authors: Anique Ducharme, Angelino Calderone, Annick Fortier, Hughes Gosselin, Robert Clement, Jean-claude Tardif
Journal: Circulation (2006)

Background: The usefulness of adriamycin (ADR), a potent antitumor agent, can be limited by the development of life-threatening cardiomyopathy and heart failure. Subcellular changes leading to heart failure are suggested to be mediated by drug-induced increases in free radical production and lipid peroxidation. We tested the hypothesis that a synthetic derivative of a potent natural antioxidant present in red wine, trans-resveratrol (TR), protects against ADR-induced cardiac damage. Methods and Results: ADR (cumulative dose, 15 mg/kg body wt) was administered in 90 rats in six equal intraperitoneal injections over a period of 2 weeks. Two weeks after the end of treatment, cardiomyopathy and congestive heart failure were characterized by ascites, congested liver, increased body weight and depressed cardiac function. Administration of TR (1000 mg/kg body weight/day (R-1000) or 300 mg/kg/day (R-300)) started 2 weeks before and continued for 2 weeks during ADR regimen, improved mean arterial pressure (MAP) (7...
Abstract 908: <i>In Vivo</i> Role of the Pharmacogenetics of Glucuronidation in the Disposition and Triglyceride Response to Fenofibrate
Authors: Robert J Straka, Na Li, Chantal Guillemette, Michael Y Tsai, Naomi Q Hanson, Jose M Ordovas, Donna K Arnett
Journal: Circulation (2007)

In spite of optimal low-density lipoprotein (LDL-C) lowering with statins, cardiovascular risk remains high for patients with elevated triglyceride (TG)-low high-density cholesterol (HDL-C) profiles. Fenofibric acid, the active moiety of fenofibrate, acts on the peroxisome proliferator-activated nuclear receptor-alpha (PPAR-α) to lower TG and raise HDL-C. The extent of lipid response has been shown to be associated with serum concentrations (conc.) of fenofibric acid. In vitro work confirms fenofibric acid is primarily eliminated by UDP-glucuronosyltransferases (UGTs) including UGT2B7, and others (UGT1A1, UGT1A3 and UGT1A9). Therefore, we hypothesized genetic variations in UGT activity may be associated with fenofibric acid conc. and thus may influence lipid response. Purpose: To test if the A-327G SNP (rs7662029) for UGT2B7, which has been shown to modulate UGT2B7 expression in vitro, is associated with serum conc. of fenofibric acid and TG response in vivo . Methods: As part of the NHLBI sponsored Genetics of Lipid Lowering Drugs and Diet Network (GOLDN) study, participants providing consent and not currently taking lipid lowering medications, were analyzed for fasting lipid response pre and post 21 days of once daily 160mg fenofibrate. TG response was calculated by the log of the ratio of the average of the 2 pre- and post-fenofibrate exposure TG determinations. Associations between UGT2B7 A-327G genotype and steady-state trough fenofibric acid conc. as well as TG response were analyzed by linear regression. Results : 745 participants (51% male) with both genotype and phenotype data were included. The mean (SD) age was 49 (16) years and the median (25 th ,75 th percentile) % change in TG concentrations was -32.3 (−45.2, −19.0). The G allele frequency for UGT2B7A&gt;G was 0.49 and was in HWE (p = 0.8). After adjusting for age, age 2 , sex, alcohol use, height and serum creatinine, strong associations were observed between UGT2B7 A-327G genotypes and steady-state trough fenofibric acid conc. (log-transformed, p = 4 × 10 −8 ) as well as TG response (p = 0.002, also adjusted for baseline TG). Conclusion : This study suggests UGT2B7 A-327G genotype may contribute to TG response by way of influencing glucuronidation activity of fenofibric acid.
Abstract 16175: Effect of Dietary Intake of Kiwi Fruit on 24-Hour Ambulatory Blood Pressure
Authors: Mette Svendsen, Tor O Klemsdal, Eli Heggen, Ingar Holme, Terje R Pedersen, Ingebjorg Seljeflot, Rune Blomhoff, Serena Tonstad
Journal: Circulation (2011)

Objective Kiwi fruit contains lutein, an oxycarotenoid that has antioxidant properties. An increased antioxidant capacity may lower blood pressure (BP) through modulation of nitric oxide mediated v...
Glycemic Control and Excess Mortality in Type 1 Diabetes
Authors: Gianluca Tornese, Martina Tubaro, Alessandro Ventura
Journal: New England Journal of Medicine (2015)

To the Editor: Lind et al. (Nov. 20 issue)1 found that patients with type 1 diabetes and a glycated hemoglobin level of 6.9% or lower had a risk of death that was twice as high as the risk among matched controls. The hazard ratio for death from cardiovascular disease was 3.64 among patients with diabetes who had normoalbuminuria (albumin:creatinine ratio,  0.7 mg per millimole), is a strong predictor of coronary heart disease and death in apparently healthy persons.2 In a study involving adolescents with type 1 diabetes, participants in the highest tertile of urinary albumin excretion had more evidence of early renal and cardiovascular disease than those in the lower tertiles.3 We believe that it would have been wise to use this low cutoff point in analyses to assess the true increased risk of death among patients with diabetes. Furthermore, it may be reasonable to use angiotensin-converting–enzyme inhibitors to modify low-grade microalbuminuria in an effort to reduce the incidence of cardiovascular events.4
Abstract 16787: Impact of Aging on Progenitor Cell Homing for Angiogenesis
Authors: Hong Yu, Qiyuan Xu, Jain'An Wang, Ming-Sheng Zhou, Jennipher Adi, Keith Webster
Journal: Circulation (2011)

Reduced numbers and activity of circulating progenitor stem cells are associated with aging and have been linked with coronary artery disease. Chemokine stromal cell-derived factor-1 (SDF-1) and its receptor CXCR4 mediate bone marrow cell mobilization, tissue homing and engraftment. We recently reported that calcium regulates CXCR4 expression in combination with SDF-1. We assessed the hypothesis that defective CXCR4 expression develops with aging and disease, which results in less progenitor cell homing to vascular lesion site and inefficient repair. CXCR4 expression and its function were compared between bone marrow cells of aged ApoE null mice (ApoE -/- ) that had been fed with a high-fat, high-cholesterol diet for 6-months and 6-week old young ApoE -/- mice. We found that CXCR4 surface expression is age-dependent. Age and atherosclerosis correlated with significantly lower surface expression of CXCR4 that was less inducible by calcium. The impaired calcium response was associated with defective calcium influx and was partially recovered by treatment with the calcium ionophore ionomycin. The aged ApoE -/- mice fed high fat for 6-months had similar characteristics as the 24-month old wild type mice in defective CXCR4 expression and SDF-1 regulation. Cells from aged, atherogenic ApoE-/- mice also displayed defective homing to SDF-1 and the animals had lower serum and bone marrow levels of SDF-1. We conclude that during the evolution of atherosclerosis in ApoE-/- mice there is a progressively reduction of bone marrow cell CXCR4 expression and function, and reduced serum and bone marrow levels of SDF-1. These changes mute the homing capability of bone marrow cells and may contribute to the progression of atherosclerosis in this model.
Accuracy of OCT, Grayscale IVUS, and Their Combination for the Diagnosis of Coronary TCFA
Authors: Kenichi Fujii, Hiroyuki Hao, Masahiko Shibuya, Takahiro Imanaka, Masashi Fukunaga, Kojiro Miki, Hiroto Tamaru, Hisashi Sawada, Yoshiro Naito, Mitsumasa Ohyanagi, Seiichi Hirota, Tohru Masuyama
Journal: JACC. Cardiovascular imaging (2015)
Using citation analysis to ease information overload in oncology
Authors: E. V. Bernstam, J. R. Herskovic, F. Meric-Bernstam
Journal: Journal of Clinical Oncology (2005)

6036 Background: Clinicians, researchers and patients access the published oncology literature but there are too many articles for humans to review. For example, a PubMed search for “breast cancer” returns 132,007 articles. Collections of important articles such as the Society of Surgical Oncology Annotated Bibliography (SSO-AB) help, but are difficult to create and update. Therefore, we need to automatically identify important articles. Methods: Qubec is a novel information retrieval system which combines PubMed (articles) and the Science Citation Index (citations from one article to another). Each article was scored using the number of times it was cited or journal impact factor if never cited. We tested this strategy for its ability to identify important articles as selected by experts in the SSO-AB, a collection of 380 articles on 10 tumors. Results: Our algorithm ranked important articles higher in the result list than PubMed. With Qubec, a user must review fewer articles to encounter 50% of the SSO-AB than using PubMed (<10%), even if all articles that were published after the last SSO-AB article are eliminated (time-adjusted). Conclusions: Citation analysis can identify important articles and place them near the top of large result sets to alleviate information overload in oncology. No significant financial relationships to disclose.
The Nature of Radiation Injury to Amphibian Cell Nuclei
Authors: William R. Duryee
Journal: JNCI Journal of the National Cancer Institute (1949)

Journal Article The Nature of Radiation Injury to Amphibian Cell Nuclei Get access William R. Duryee William R. Duryee National Cancer Institute, National Institutes of Health, Public Health Service, Bethesda, Md., and Department of Terrestrial Magnetism, Carnegie Institution of Washington, D. C. Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 10, Issue 3, December 1949, Pages 735–795, https://doi.org/10.1093/jnci/10.3.735 Published: 01 December 1949 Article history Received: 18 October 1949 Published: 01 December 1949
Abstract 4576: Impact of Newly Appeared Ulcer-like Projection on Clinical Outcomes of Patients With Type B Aortic Intramural Hematoma
Authors: Takeshi Kitai, Shuichiro Kaji, Atsushi Yamamuro, Koichi Tamita, Natsuhiko Ehara, Makoto Kinoshita, Atsushi Kobori, Yoshimori An, Kitae Kim, Tomoko Tani, Yutaka Furukawa
Journal: Circulation (2009)

Background: Long-term clinical outcomes of patients with type B aortic intramural hematoma (IMH) with/without ulcer-like projection (ULP) has not been fully discussed. The purpose of this study was...