Immunotherapy of Type I Diabetes Mellitus
Authors: GEORGE S. EISENBARTH
Journal: Annals of Internal Medicine (1985)

Editorials1 June 1985Immunotherapy of Type I Diabetes MellitusGEORGE S. EISENBARTH, M.D., Ph.D.GEORGE S. EISENBARTH, M.D., Ph.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-102-6-846 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptIn most patients, type I diabetes results from autoimmune beta-cell destruction in the setting of a genetically determined predisposition (1). Approximately 95% of patients with type I diabetes express HLA antigens DR3 or DR4 or both (2), and within families, siblings with type I diabetes have in common at least one and often both HLA-haplotypes (3). In many patients, anti-islet antibodies precede overt diabetes. Several assays for anti-islet antibodies have been developed but the only assay that has shown prognostic significance measures binding of antibodies to non-fixed, frozen sections of normal human pancreas (4-8). Only a few research centers have...References1. EISENBARTH G. Autoimmune beta cell insufficiency: diabetes mellitus type I. Triangle. 1985;23:111. Google Scholar2. NERUP J, CHRISTY M, PATZ P, RYDER L, and SVEJGAARD A. Aspects of the genetics of insulin-dependent diabetes mellitus. In: ANDREANI D, DIMARIO U, FEDERLIN KF, HEDING LG, eds. Immunology in Diabetes. London: Kimpton Publishing; 1984. Google Scholar3. GORSUCH A, SPENCER K, LISTER J, WOLF E, BOTTAZZO G, and CUDWORTH A. Can future type I diabetes be predicted? A study in families of affected children. Diabetes. 1982;31:862-6. CrossrefMedlineGoogle Scholar4. IRVINE W, GRAY R, and STEEL J. Islet cell antibody as a marker for early stage type I diabetes mellitus. In: IRVINE WJ, ed. The Immunology of Diabetes. 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Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: GEORGE S. EISENBARTH, M.D., Ph.D.Affiliations: Joslin Diabetes Center Brigham and Women's Hospital New England Deaconess Hospital Harvard Medical School Boston, Massachusetts PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byImmunological concepts in insulin-dependent (Type I) diabetes mellitus 1 June 1985Volume 102, Issue 6Page: 846-848KeywordsAntibodiesAntigensDiabetes mellitusHuman leukocyte antigenPancreas ePublished: 1 December 2008 Issue Published: 1 June 1985 PDF downloadLoading ...