tbuckley/cabot-search huggingface dataset:
The bereavement exclusion may not be applicable in real world settings
Authors: EMMANUELLE CORRUBLE
Journal: World Psychiatry (2012)

We thank Wakefield and First for citing three of our papers in their review article about the validity of the bereavement exclusion to major depression 1. However, we believe that their view about our work is incomplete and misleading. First, they argue that no special training or checklist was used in our studies. This point is not correct, as clarified in our first paper 2 (“The MDE module of the Mini-International Neuropsychiatric Inventory (MINI) structured interview was used”), in the second 3 (“Doctors had a prestudy training session about DSM-IV MDE criteria, including the bereavement exclusion criterion. Moreover, they had to assess each MDE criterion (yes/no) to check the diagnosis of MDE”) and in the third 4 (“Clinicians, who were trained about the DSM-IV MDE criteria prior to the study, were asked to check each DSM-IV MDE diagnosis criterion”). Second, they argue that the bereavement exclusion was inaccurately applied in our studies. Their view might be more dogmatic than pragmatic. Actually, our results from two different samples including 4,252 clinicians and 30,603 patients 2,3,4 show that the bereavement exclusion criterion has a poor discriminant validity in treatment seeking individuals. Indeed, there are two possible explanations for these results. The first is that the bereavement exclusion was not applied correctly by the trained physicians involved in the studies. The second, much more plausible, is that the bereavement exclusion is actually not applicable in real world settings, due to its complexity. Thus, we conclude that the bereavement exclusion criterion is not discriminant in real world settings, and that further studies with a design similar to ours are needed to confirm our data. Finally, we think that the bereavement exclusion has to be reconsidered, even possibly deleted, in the DSM-5 definition of major depressive episode.
Presence and development of atrial fibrillation in chronic heart failure
Authors: Dirk J. van Veldhuisen, Halfdan Aass, Dia El Allaf, Peter H.J.M. Dunselman, Lars Gullestad, Matti Halinen, John Kjekshus, Lis Ohlsson, Hans Wedel, John Wikstrand
Journal: European Journal of Heart Failure (2006)
Abundant Tax protein expression in CD4+ T cells infected with human T-cell lymphotropic virus type I (HTLV-I) is prevented by cytotoxic T lymphocytes
Authors: Emmanuel Hanon, Sarah Hall, Graham P. Taylor, Mineki Saito, Ricardo Davis, Yuetsu Tanaka, Koichiro Usuku, Mitsuhiro Osame, Jonathan N. Weber, Charles R. M. Bangham
Journal: Blood (2000)
Anastomotic airway complications after lung transplantation: Risk factors, treatment modalities and outcome: A single center experience
Authors: Jonas Yserbyt, Christophe Dooms, Robin Vos, Lieven Dupont, Marc Decramer, Dirk Van Raemdonck, Geert M. Verleden
Journal: European Respiratory Journal (2014)

Background . Anastomotic airway complications (AC) give rise to morbidity and mortality after lung transplantation. A more profound knowledge about the prevalence of AC and the predisposing factors and evolving therapeutic strategies for AC is needed.

Methods . We conducted a retrospective analysis of 808 consecutive bronchial anastomoses. A patient-dependent score (PDS) and Shennib and Massard anastomosis classification was allocated to each AC. We aimed to define risk factors associated with AC and to develop a model that might predict the most appropriate treatment strategy for AC.

Results . The overall prevalence of AC was 10%. After multivariate analysis, significant risk factors for AC were receptor age (OR (95%CI) 3.69 (1.37-9.93)), pre-operative TLC (OR 2.06 (1.01-4.22)), microbiological colonization (OR 2.34 (1.30-4.23)), right-sided anastomosis (OR 2.07 (1.16-3.70)) and Pa02/FiO2 <300 (OR 2.19 (1.17-4.10)). No specific treatment was initiated in 59 AC and a spontaneous resolution was obtained in 48. A logistic regression model including the case-specific Shennib and Massard classification along with a PDS correctly predicted spontaneous resolution in 91% and necessity for extended treatment of AC in 87%.

Conclusion . Anastomotic airway complications are not infrequent after lung transplantation, but the identified risk factors are not easily controllable. The indication for either a conservative strategy or invasive intervention should be carefully considered, since most cases resolve or stabilize with time.
Which factors determine the need for oxygen supplementation during exercise training in patients with COPD
Authors: Antenor Rodrigues, Aline Nellessen, Fabio I. Ikezaki, Mariana Di Martino, Leila Donaria, Karina C. Furlanetto, Thais Sant'Anna, Nidia A. Hernandes, Fabio Pitta
Journal: European Respiratory Journal (2014)

Aim : To analyse the differences between patients with COPD who need oxygen supplementation (OS) or not during high intensity exercise training (ET); and to identify which factors influence this need. Methods : Thirty-two patients with COPD were assessed concerning lung function (spirometry), respiratory muscle strength (manovacuometry) and exercise capacity (Incremental Shuttle Walking Test [ISWT] and 6-Minute Walking Test [6MWT]). Further, patients were included in a high-intensity ET program (3 times/week, 12 weeks), and divided into 2 groups: those who needed oxygen supplementation (G_O2 n=10) or not (G_notO2 n=22) during the first week of ET. Results : Compared with G_notO2, G_O2 group had worse airway obstruction (FEV1 26[21-28] vs 52[26-65] %pred), maximum expiratory pressure (PEmax 79[53-91] vs 104[90-115] %pred) and exercise capacity (ISWT 295±21 vs 444±43m; 6MWT %pred of 68[58-72] vs 80[67-86])( P <0.05 for all). Regression model included variables which were more strongly associated with the oxygen need during the ET according to the Chi-square test ( P <0.20): PEmax in absolute values ( P =0.02) and 6MWT %pred ( P =0.03). In the regression analysis, only 6MWT distance (%pred) was determinant of oxygen need during ET (prevalence ratio=8.1; P =0.03). Conclusion : Patients with COPD who need OS during high-intensity ET have worse lung function, expiratory muscle force and exercise capacity in comparison to patients who do not need it. The prevalence ratio for patients with more markedly impaired exercise capacity assessed by the 6MWT to need oxygen supplementation during high-intensity ET is 8.1 times higher than patients with better performance in the test.
Abstract 1512: Detection of somatic alterations in plasma from lung cancer patients
Authors: Jose L. Costa, Ana Justino, Ana Barroso, Barbara Parente, Jose C. Machado
Journal: Cancer Research (2014)

Abstract Tumor-specific (somatic) mutations in plasma can serve as biomarkers for tumor detection, monitor tumor response to specific therapies, detect residual disease after surgery, and long-term follow-up. The intrinsic low abundance of circulating cell-free tumor DNA (cfDNA) makes the detection and quantification of such mutations in plasma a challenging task. This small scale study aims to establish a comprehensive strategy to be used in the detection of clinical relevant somatic alterations in plasma of lung cancer patients. Plasma samples obtained at different stages of disease progression and/or treatment were collected from a group of 11 lung cancer patients and used to isolate cfDNA. Genetic alterations in the EGFR gene (p.E746_A750del and p.L858R) identified at diagnosis in tumor biopsies were used as surrogate markers to optimize and validate the next generation sequencing strategy and data analysis workflow. The Ion AmpliSeq Colon and Lung cancer panel was used to analyze hotspot and targeted regions of 22 genes implicated in colon and lung cancers, including the EGFR gene mutations mentioned. The amplified products were used to prepare libraries and were sequenced using the Ion PGM system. Quantitative real time PCR and digital PCR assays were used to confirm selected results. Tumor derived genetic alterations could be identified in as little as 10ng of cfDNA. EGFR alterations identified in cfDNA mirrored the alterations identified in all tumor biopsies. EGFR alterations with allelic frequencies as low as 3% could be detected in cfDNA. Additionally, in case of samples collected after therapy, a clear decrease in the cfDNA allelic frequency of the EGFR mutation, that made the patient eligible for therapy, was observed. Furthermore, the screening of a larger panel of genes allowed the identification in two cases of additional gene mutations (e.g. MET and KRAS) that may have impact in the clinical management of patients. In this study, we demonstrate the capacity to identify clinically relevant somatic EGFR mutations in plasma. The possibility to assess information from a larger panel of genes makes this strategy attractive for further optimization of treatment options. The strategy is now being extended to a larger cohort of patients to push forward the concept of liquid biopsy in the clinical management of cancer patients. Citation Format: Jose L. Costa, Ana Justino, Ana Barroso, Barbara Parente, Jose C. Machado. Detection of somatic alterations in plasma from lung cancer patients. [abstract]. In: Proceedings of the 105th Annual Meeting of the American Association for Cancer Research; 2014 Apr 5-9; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2014;74(19 Suppl):Abstract nr 1512. doi:10.1158/1538-7445.AM2014-1512
KAPOSI'S SARCOMA WITH SECONDARY INVOLVEMENT OF THE JEJUNUM, PERFORATION AND PERITONITIS
Authors: N MITCHELL, I A FEDER
Journal: Annals of Internal Medicine (1949)

Case Reports1 August 1949KAPOSI'S SARCOMA WITH SECONDARY INVOLVEMENT OF THE JEJUNUM, PERFORATION AND PERITONITISNATHAN MITCHELL, M.D., ISIDORE A. FEDER, M.D., F.A.C.P.NATHAN MITCHELL, M.D.Search for more papers by this author, ISIDORE A. FEDER, M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-31-2-324 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptSince Kaposi's original description of multiple hemorrhagic sarcoma of the skin in 1872, more than 600 cases have been reported in the literature. In the great majority of these cases the skin has been primarily affected. A large number progress slowly for many years and at autopsy show no spread beyond the cutaneous site. However, the finding of sarcomatous deposits in the viscera is a common one. Almost every organ of the body has been implicated. In addition to the skin the most frequent sites of involvement are the penis, the gastrointestinal tract, the upper and lower respiratory tracts and...Bibliography1. STATS D: The visceral manifestations of Kaposi's sarcoma, Jr. Mt. Sinai Hosp., 1946, xii, 971-983. Google Scholar2. NESBITTMARKZIMMERMAN SPFHM: Disseminated idiopathic hemorrhagic sarcoma (Kaposi's disease); report of case with necropsy findings, Ann. Int. Med., 1945, xxii, 601-605. Google Scholar3. AEGERTERPEALE EEAR: Kaposi's sarcoma; a critical survey, Arch. Path., 1942, xxxiv, 413-422. Google Scholar4. TEDESCHIFOLSOMCARNICELLI CGHFTJ: Visceral Kaposi's disease, Arch. Path., 1947, xliii, 335-357. Google Scholar5. WILLIS RA: The spread of tumors in the human body, 1934, J. & A. Churchill, London. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Brooklyn, N. Y.*Received for publication July 23, 1947.From the Departments of Pathology and Medicine of the Beth El Hospital. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byEnfermedad de KaposiMalignant DiseaseIntestinal Kaposi's without AIDSMalabsorption Syndromes and Intestinal Protein LossKaposi's sarcoma and lymphoma of the gut in AIDSGastrointestinal and Hepatobiliary Neoplasms in AIDSKaposi’s SarcomaGastrointestinal Kaposi's sarcoma in patients with acquired immunodeficiency syndromeKaposi's sarcomaKaposi’s Sarcoma Presenting with Diarrhea and Protein-Losing EnteropathyStudies in Kaposi's sarcoma. Postmortem findings and disease patterns in womenKaposi's Sarcoma Presenting with Abdominal SymptomsKaposi's sarcoma 1 August 1949Volume 31, Issue 2Page: 324-329KeywordsAutopsyGastrointestinal tractHospital medicineJejunumKaposi sarcomaPenisPeritonitisRespiratory systemSarcoma ePublished: 1 December 2008 Issue Published: 1 August 1949 PDF downloadLoading ...
Mouthwash may treat malaria
Authors: Abi Berger
Journal: BMJ (2001)

Triclosan, a substance commonly found in mouthwashes and deodorants, has shown promise as an antimalarial treatment.

Researchers in India have been investigating the use of triclosan as an antimalarial and have found that in mice this antimicrobial agent can completely clear the parasite. Dr Namita Suriola and her team at the Jawaharlal Nehru Centre for Advanced Scientific Research in Bangalore have also …
The proof of the pudding is in the eating: an outbreak of emetic syndrome after a kindergarten excursion, Berlin, Germany, December 2007
Authors: G O Kamga Wambo, F Burckhardt, C Frank, P Hiller, H Wichmann-Schauer, I Zuschneid, J Hentschke, T Hitzbleck, M Contzen, M Suckau, K Stark
Journal: Eurosurveillance (2011)

An outbreak of food poisoning (emetic syndrome) occurred in three kindergartens (A, B and C) in Berlin, Germany, on 3 December 2007 after an excursion during which food was served. We conducted a retrospective cohort study among the kindergarten children and personnel who participated in the trip. The overall attack rate among the 155 participants was 30%. It was 31% among the 137 children (aged two to six years) and 17% among adults (n=18). The consumption of rice pudding was significantly associated with disease. Among those who ate rice pudding, the attack rate was 36%, compared with 0% for non-eaters (relative risk: infinite, p<0.001, aetiological fraction: 100%), but differed significantly between kindergartens A (43%), B (61%) and C (3%), probably because groups were served from different pots. Bacillus cereus sensu stricto was identified from one vomit sample. The clinical and epidemiological characteristics suggest that B. cereus emetic toxin (cereulide) was the causative agent, although it could not be proven in the single vomit isolate. Inadequate food handling most probably led to the outbreak. Single-portion ready-to-eat rice pudding was recommended for subsequent excursions and no further cases of food poisoning occurred.
Abstract #LB-262: A Randomized Placebo-Controlled Trial of a Selective Androgen Receptor Modulator in patients with cancer cachexia
Authors: Ronald Morton, K. Gary Barnette, Michael Hancock, Domingo Rodriguez, James Dalton, Mitchell Steiner
Journal: Cancer Research (2009)

AACR Annual Meeting-- Apr 18-22, 2009; Denver, CO

Many common malignancies, including non small cell lung cancer, colorectal cancer, pancreatic cancer and others, can lead to a wasting state termed cancer cachexia, which is a hypermetabolic state that leads to catabolism and subsequent reductions in lean body mass (LBM). Increases and/or better maintenance of LBM should result in improvements in quality of life and treatment response in cancer patients. We have developed selective androgen receptor modulators (SARMs) to investigate the effects on both LBM and physical performance. Herein we report the results of a phase II trial of Ostarine in patients with cancer cachexia. Methods: We conducted a randomized double-blind placebo controlled trial in 159 subjects with non small cell lung cancer, colorectal cancer, non-Hodgkin lymphoma, breast cancer, or chronic lymphocytic leukemia. Entry criteria included a 2% or greater weight loss within six months of screening, life expectancy of greater than 6 months, and ECOG score of less than or equal to 1. Subjects were randomized to receive either: 1mg Ostarine, 3mg Ostarine, or matching placebo daily for 16 weeks. The primary end point was total LBM measured by DEXA scan. Secondary end points included muscle performance measured by stair climb time and power, gait speed (6-meter walk) and grip strength. Results: Mean weight loss over the 6 months prior to study entry was 8.8% of total body weight. One hundred subjects were included in this MITT analysis. Subjects in both Ostarine treatment arms experienced an improvement in LBM. The change from baseline in LBM for the placebo, 1mg and 3mg treatment groups was 0.1 kg (p=0.874 compared to baseline), 1.5 kg (p=0.001) and 1.3 kg (p=0.045), respectively. Performance was assessed via a 12 step stair climb. Subjects in both treatment arms demonstrated improved muscle function measured both by stair climb time and stair climb power. The change from baseline in stair climb power in the placebo, 1mg and 3mg treatment groups respectively was 0.23 watts (p=0.666 compared to baseline), 35.2 watts (p=0.003) and 44.7 watts (p=0.003). Statistically significant decreases from baseline in stair climb time were also observed. Changes from baseline in gait speed and grip strength were not different between the Ostarine treatment arms and placebo. Conclusions: Ostarine treatment results in clinically meaningful and statistically significant improvements of LBM and muscle performance in cancer cachexia subjects that have experienced significant (mean 8.8%) weight loss.

Citation Information: In: Proc Am Assoc Cancer Res; 2009 Apr 18-22; Denver, CO. Philadelphia (PA): AACR; 2009. Abstract nr LB-262.
Detection and Localization of Intraepithelial Neoplasia and Invasive Carcinoma Using Fluorescence-Reflectance Bronchoscopy: An International, Multicenter Clinical Trial
Authors: Eric Edell, Stephen Lam, Harvey Pass, York E. Miller, Thomas Sutedja, Timothy Kennedy, Gregory Loewen, Robert L. Keith
Journal: Journal of Thoracic Oncology (2009)
服用COX-2抑制剂或传统非甾体抗炎药患者发生心肌梗死的危险：一项人群巢式病例-对照研究
Authors: Julia, Hippisley-Cox, Carol, Coupland, 田新平（译）, 董怡（校）
Journal: BMJ (2005)

目的 明确2000年至2004年问在初级医疗机构服用环氧化酶2（COX-2）抑制剂和其他非甾体抗炎药（NSAIDs）的患者发生心肌梗死的相对危险性；了解既往有和无冠心病患者、服用和未服用阿司匹林患者发生这种危险的情况。设计 重叠病例一对照研究。参加单位 367个向英国UK QRESEARCH数据库提交资料的初级医疗单位和英格兰、威尔士及苏格兰的所有医疗决策部门和卫生局。研究对象 在研究进行的4年间首次被诊断为心肌梗死的9218人，及86349名年龄、年份、性别和就诊医疗机构配对的对照人群。结果评价 计算与罗非昔布、塞来昔布、萘普生、布洛芬、双氯芬酸和其他选择性和非选择性NSAIDs相关的心肌梗死的校正和未校正几率比及95％可信区间。几率比计算时对吸烟情况、共患疾病、贫富情况和他汀类药物、阿司匹林和抗抑郁药物的使用情况做了校正。结果 与在过去3年内未使用过罗非昔布的患者相比，使用罗非昔布的患者发生心肌梗死的危险性明显增加（校正几率比为1．32，95％可信区间为1．09—1．61）；服用双氯芬酸（校正几率比和95％可信区间分别是L55，1．39～1．72）和布洛芬者（校正几率比和95％可信区间分别为1．24，1．11～1．39）发生心肌梗死的危险性也明显升高。服用其他选择性NSAIDs、萘普生和非选择性NSAIDs的危险性也是增加的；服用这些药物的危险性在〈0．05水平上显著增加，在〈0．0l水平上没有显著增加，但趋势检验时在〈0．01水平上是显著增加的。任何一种NSAIDs与阿司匹林或冠心病之间都没有相互影响。结论 尽管对多种可能的混杂因素进行校正，这些研究结果提示服用罗非昔布、双氯芬酸和布洛芬可以增加发生心肌梗死的危险。没有发现支持服用萘普生可以降低心肌梗死发生率的证据。这是一项观察研究，可能会受到不�
Abstract 15703: Hypertrophic Cardiomyopathy with Normal ECG: Clinical Meaning and Prognostic Implications
Authors: Chiara Calore, Cinzia Cianfrocca, Ines Iacovella, Fernando M Di Paolo, Francesco Pelliccia, Francesca Santi, Gaetano Thiene, Cristina Basso, Antonio Pelliccia, Sabino Iliceto, Domenico Corrado, Paola Melacini
Journal: Circulation (2011)

Objectives: The present study was designed to assess proportion of patients with hypertrophic cardiomyopathy (HCM) showing no electrocardiographic (ECG) changes or isolated increase of QRS voltage,...
Coping with Heart Transplantation: A Challenge for Liaison Psychiatry
Authors: Roger Zumbninnen
Journal: Psychotherapy and Psychosomatics (1989)

Heart transplantation confronts the patient with major physical, psychological and social demands, both before and after the operation. Psychological adjustment with these stressors requires effective coping abilities. In most cardiac transplant units, a liaison psychiatrist or a psychologist is associated to the cardiosurgery team, in order to provide the medical team with assistance in the selection of candidates and to help patients to cope with the adaptive tasks they are faced with during the transplantation process. Many questions about the process of coping with heart transplantation remain unanswered. This article, based upon the literature review and the author's clinical experience, focuses on some critical issues regarding assessment and clinical usefulness of coping mechanisms in cardiac transplantation.
Artificially designed pathogens – a diagnostic option for future military deployments
Authors: Andreas E. Zautner, Wycliffe O. Masanta, Rebecca Hinz, Ralf Matthias Hagen, Hagen Frickmann
Journal: Military Medical Research (2015)

Diagnostic microbial isolates of bio-safety levels 3 and 4 are difficult to handle in medical field camps under military deployment settings. International transport of such isolates is challenging due to restrictions by the International Air Transport Association. An alternative option might be inactivation and sequencing of the pathogen at the deployment site with subsequent sequence-based revitalization in well-equipped laboratories in the home country for further scientific assessment. A literature review was written based on a PubMed search. First described for poliovirus in 2002, de novo synthesis of pathogens based on their sequence information has become a well-established procedure in science. Successful syntheses have been demonstrated for both viruses and prokaryotes. However, the technology is not yet available for routine diagnostic purposes. Due to the potential utility of diagnostic sequencing and sequence-based de novo synthesis of pathogens, it seems worthwhile to establish the technology for diagnostic purposes over the intermediate term. This is particularly true for resource-restricted deployment settings, where safe handling of harmful pathogens cannot always be guaranteed.
Sex Hormones, Amyloid Protein, and Alzheimer Disease—Reply
Authors: Sam Gandy
Journal: JAMA (2001)

To the Editor: In their Research Letter, Dr Gandy and colleagues1 found that serum concentrations of amyloid protein paralleled those of testosterone and 17-β estradiol. In attempting to associate levels of sex hormones with Alzheimer disease (AD), the authors make several incorrect assumptions.
446. A Rapid, Efficient and Feasible Method for Constructing Conditionally-Replicating Adenoviral Vectors That Specifically Target Cancer Cells with Multiple Factors
Authors: Satoshi Nagano, Yohiteru Murofushi, Setsuro Komiya, Ken-ichiro Kosai
Journal: Molecular Therapy (2004)

Conditionally-replicating adenoviral vectors (CRAs) have potentials to circumvent the limitation of current vector systems, i.e., the impossibility to deliver therapeutic gene to every cancer cell in the whole body. However, previously reported CRAs have some fundamental problems. First, cancer-specificity of these CRAs is insufficient or uncertain because they are regulated by only a single or a couple of factors. Second, it is time-consuming and laborious to construct CRAs by previous systems; it is almost impossible to efficiently construct numbers of diverse CRAs having differently combined multiple factors. As a result, there has been no systematic analysis to assess virological and biological properties of numbers of diverse CRAs simultaneously in various cancer and normal cells. In this respect, neither actual therapeutic potential nor clinical utility remains uncertain even though previous reports represented a drastic phenomenon of sole CRA in limited type of cancer cell or of animal model.