tbuckley/cabot-search huggingface dataset:
Summary of Discussion on Developmental Biology of Normal Cells
Authors: Kimball C. Atwood
Journal: Cancer Research (1968)

In this part of the symposium we have heard current ideas and experiments concerning components that bring order to the replication of genetic material and to events preceding cell division. We attempt to distinguish these from other compo nents which, although necessary, do not seem to have a co ordinating function in the replication cycle. It is convenient to visualize the coordinating subsystem as a circular chain of causation, with branches, to show that some of the events having unique temporal relations to the cycle may nevertheless not determine the subsequent steps. Disorders of such a system can be imagined in the form of permanent blockades which, al though eventually lethal, appear to be normal for some kinds of differentiated cells; or they may be imagined in the form of temporal displacements that would cause the system to dis mantle itself, as would happen for instance, if cytokinesis preceded chromosome replication. Finally, of particular interest in the context of neoplasms, are disorders in which the system remains functional, but may be thought of as isolated from controls evolved to arrest the cycle when that is appropriate to the role of the cell in an organism. The speakers discussed a number of real entities that can be fitted into the foregoing framework. The replicA³n concept, first derived from experiments with bacteria, is the principal framework of speculation in regard to the replication of the genome. Pardee discussed the struc tural integrity of the bacterial replicA³n,the attachment of the growth fork and replicating complex to the cell membrane, the dependence of septum formation on DNA synthesis, the independence of DNA synthesis on septum formation, the fre quent, though not universal, existence of a unique starting or finishing point in the chromosome, the dependence of reiniti ation on new protein synthesis, and the completion of already initiated cycles in the absence of new protein synthesis. The most certain generalization that can be made is that the initi ation of a growth fork in DNA, and its progression along the chain, are shown by experiment to be clearly separable; that is, each can be blocked independently of the other. Moreover, it is the initiation step that sets the pace in the sense that inability to provide deoxynucleoside triphosphates is not the usual limitation on DNA synthesis. The mechanism of re initiation is therefore a central problem. The hypothesis that comes most readily to mind is that initi ation may be caused by passage of the growth fork over a cer tain locus, or by doubling of a certain locus. As Lark pointed out, however, cycling (in the sense of initiation of new growth forks) continues on time when DNA synthesis is blocked. If this were true for all the cells in an asynchronous population, it would mean that neither the passage of the growth fork nor
High‐dose local steroid treatment in bronchopulmonary aspergillosis
Authors: J. H. Heinig, E. R. Weeke, S. Groth, B. Schwartz
Journal: Allergy (1988)

Two patients with allergic bronchopulmonary aspergillosis (ABPA) have been treated with a high dose (1600 μg daily) of inhaled corticosteroid for 18 months. A beneficial effect with regard to asthmatic symptoms was observed in both patients. During the first 14 months of the observation period no significant changes were observed in lung function parameters. Bronchial histamine challenge showed decreased hyperreactivity. IgE decreased in both patients, while specific IgE and IgG remained the same. After 14 months of treatment one of the patients developed severe, acute exacerbation of the ABPA and was treated with high‐dose prednisolone and local steroid. The patient is now fully recovered and has continued on local steroid therapy. The other patient had no episodes of exacerbation and remains stable on this treatment.
Testing for Heart Disease
Authors: Tracy Hampton
Journal: JAMA (2004)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Autoerotic Phenomena in Adolescence. An Analytical Study of the Psychology and Psychopathology of Onanism.
Authors: K. Menzies, Ernest Jones
Journal: JAMA (1920)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
597. Combined Suicide/Cytokine Gene Therapy of Hepatocellular Carcinoma
Authors: Anna-Lisa Stefani, Luisa Barzon, Ignazio Castagliuolo, Maria Guido, Fabio Farinati, Giorgio Palù
Journal: Molecular Therapy (2004)

Gene therapy might be a promising approach for advanced hepatocellular carcinoma (HCC) not amenable to any effective treatment. Retroviral vectors could be safely delivered directly in the tumor mass by either a percutaneous or an intra-hepatic artery approach. Aim of the study was to evaluate in vitro and in vivo efficacy of gene therapy of HCC with different retroviral vectors (LXSN-, MFG-, and SFβ91-based vectors) containing combinations of suicide (thymidine kinase of HSV-1, HSV-TK, and a mutant variant of HSV-TK with high affinity for ganciclovir, GCV) and cytokine (IL-2, IL-12, GM-CSF) genes. Comparison of vectors demonstrated that SFβ91-based retroviral vectors were the most efficient in transduction of HCC cells and in transgene expression. In vitro experiments in human and murine HCC cell lines showed dose- and time-dependent cell killing of transduced cells and efficient bystander effect after GCV treatment. A murine model of HCC was obtained by s.c. inoculation of 107 transduced and non-transduced BNL1MEA7R.1 cells in syngenic balb/c mice. Treatment with GCV led to complete or near complete regression of transduced tumors (1% of the original mass). Histological analysis of GCV-treated tumors showed inflammatory infiltration, wide necrotic and sclerotic areas and significant increase of apoptosis. In vivo experiments confirmed the bystander effect with complete regression of tumor masses containing less than 25% transduced cells. In vivo experiments also demonstrated that the combination of a cytokine gene with a suicide gene was significantly more effective in eradicating HCC than each gene alone. Moreover, mice implanted with transduced and non-transduced tumors in both flanks showed not only complete regression of thymidine kinase-positive tumors, but also growth inhibition of non-transduced tumors. In conclusion, we demonstrated the in vitro and in vivo efficacy of combined retroviral-mediated gene therapy for HCC, with a significant local bystander effect, due to suicide gene expression, and systemic therapeutic efficacy in vivo, accounted to cytokine production. These results are of interest for gene therapy applications in patients with advanced HCC.
Flow dynamics in the main pulmonary artery after the Fontan procedure in patients with tricuspid atresia or single ventricle.
Authors: M Nakazawa, K Nojima, H Okuda, Y Imai, T Nakanishi, H Kurosawa, A Takao
Journal: Circulation (1987)

We analyzed the flow velocity pattern in the main pulmonary artery after Fontan operation in patients with tricuspid atresia (n = 10) or with single ventricle (n = 10) by means of a catheter-mounted velocity probe. The area underneath the velocity signal of the forward flow was integrated, and ratios of the portions during atrial systole and during the diastolic phase to the total area (Fa and Fd) were calculated. The Fa was 0.54 +/- 0.09 in patients with tricuspid atresia and 0.45 +/- 0.05 in those with single ventricle (p less than .01). Cardiac output, obtained by the thermodilution method, was 2.45 +/- 0.48 liters/min/m2 in patients with tricuspid atresia and 2.75 +/- 0.72 liters/min/m2 in those with single ventricle. The forward flow during atrial contraction, calculated by multiplying Fa by cardiac output, was 1.32 +/- 0.35 liters/min/m2 in patients with tricuspid atresia and 1.23 +/- 0.33 liters/min/m2 in those with single ventricle. The diastolic forward flow, calculated from Fd and cardiac output, was 0.99 +/- 0.25 liter/min/m2 in patients with tricuspid atresia and 1.52 +/- 0.45 liters/min/m2 in those with single ventricle (p less than 0.005). The sum of cross-sectional areas of the right and left pulmonary arteries normalized by body surface area (PA index) was 282 +/- 85 cm2/m2 in patients with tricuspid atresia and 462 +/- 65 cm2/m2 in those with single ventricle (p less than .005). The Fa was inversely correlated with the PA index in the whole group (r = -.69) and also in the tricuspid atresia group alone (r = -.87).(ABSTRACT TRUNCATED AT 250 WORDS)
Stability of asthma control with regular treatment: an analysis of the Gaining Optimal Asthma controL (GOAL) study
Authors: E. D. Bateman, J. Bousquet, W. W. Busse, T. J. H. Clark, N. Gul, M. Gibbs, S. Pedersen
Journal: Allergy (2008)

Uncontrolled asthma is characterized by variability. Current asthma guidelines recommend focussing on the achievement and maintenance of control but few studies have examined in detail, using composite measures of control, the stability and potential duration of control once achieved. In this post-hoc analysis of the results of the Gaining Optimal Asthma controL (GOAL) study, we examine the association between the level of asthma control achieved during the step-up phase of the study and the stability of control experienced during the maintenance phase.GOAL was a 1-year, randomized, stratified, double-blind study of 3421 patients with uncontrolled asthma, which compared salmeterol/fluticasone propionate combination with fluticasone propionate in achieving two composite, guideline-based measures of control: totally controlled and well-controlled asthma. We analysed the proportion and duration of time spent in control, the effect of treatment on asthma stability, and the impact of asthma control stability on unscheduled use of healthcare resources.In patients achieving well-controlled or totally controlled asthma, at least well-controlled asthma was maintained for a median of almost 3 and 6 months, and for more than 85% and 95% of weeks of follow-up, respectively. A high level of stability was confirmed in a Markov analysis investigating transitional probability of change in control status. Variability in control was associated with increased probability of an unscheduled healthcare resource use (odds ratio: 1.06, P < 0.001).Most patients achieving guideline-defined control can maintain at least a similar level of control with regular, stable dosing, with little likelihood of losing control.
Microsatellite instability is rare in B-cell non-Hodgkin's lymphomas
Authors: Barbara Gamberi, Gianluca Gaidano, Nasser Parsa, Antonino Carbone, Silvio Roncella, Daniel M. Knowles, Diane C. Louie, Darryl Shibata, R.S.K. Chaganti, Riccardo Dalla-Favera
Journal: Blood (1997)
Chronic Sinus Infection in Relation to Systemic Disease
Authors: Noble W. Jones, Frank B. Kistner
Journal: Annals of Internal Medicine (1931)

Article1 January 1931Chronic Sinus Infection in Relation to Systemic DiseaseNOBLE W. JONES, FRANK B. KISTNERNOBLE W. JONESSearch for more papers by this author, FRANK B. KISTNERSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-4-7-752 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptWhen one refers to chronic hyperplastic sinusitis, and especially to the non-purulent form of chronic hyperplastic sinusitis, as a focal infection of importance, one treads upon debatable ground. Many rhinologists of note believe that chronic inflammation of the nasal accessory sinuses plays little, if any, role in the causation of systemic disease1. Although our work during the past five years has led us to other conclusions, yet we have respected these views, and they have, we believe, tempered our enthusiasm and have influenced the forming of our opinions.The work now presented has been gleaned from an unfinished analysis of...1 Shambaugh (Jour. Am. Dent. Assn., Vol. 16, 5, May, 1929, pp. 773-781) for instance says: "Regarding the question of sinus disease as a focus for systemic infection, I am of the conviction that chronic sinus disease is a much less important factor in producing infection than are either the teeth or the tonsils. ... "A demonstrable sinus infection occurring in connection with systemic disease appears to be extremely rare. ... "I have been interested in the problem of focal infection since these studies first began, but I have seen few patients in whom there appeared to be any justifiable suspicion that chronic sinus disease was a factor in producing a systemic infection." Google Scholar2 BENSON RL (The Present Status of Coronary Arterial Disease) Arch. Path. & Lab. Med., Vol. 2, Dec., 1926, pp. 876-916. Google Scholar3 CLAWSON BJ (Myocardium in Non-Infectious Myocardial Failure) Am. J. Med. Sci., Vol. CLXVIII, 5, Nov., 1924, p. 648. CrossrefGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Portland, Oregon*(Abstract of clinic held February 14. 1930, at the Fourteenth Annual Clinical Session of the American College of Physicians, Minneapolis, Minnesota.)†From the Departments of Medicine and Oto-Laryngology, Medical Department, University of Oregon. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byKasuistik 1 January 1931Volume 4, Issue 7Page: 752-771KeywordsInfectious diseasesInflammation ePublished: 1 December 2008 Issue Published: 1 January 1931 PDF downloadLoading ...
Abstract 4360: Hypoxia-induced miR-372 targets p62 to affect the progression of oral carcinoma
Authors: Li-Yin Yeh, Shu-Chun Lin, Chung-Ji Liu, Yong-Kie Wong, Kuo-Wei Chang
Journal: Cancer Research (2014)

Abstract Oral squamous cell carcinoma (OSCC) is one of the prevalent neoplasms worldwide. Recent studies have shown that miRNAs were involved in the pathogenesis of various human malignancies, which function by post-transcriptional down-regulation of target genes. Also, hypoxia is a feature of most tumors and plays an important role in regulating tumor progression and resistance to therapy. In our previous study, we found that miR-372 was highly expressed in OSCC tissues. Other studies have shown the oncogenic roles of miR-372 in regulating the cell cycle and apoptosis in tumor cells by targeting different targets. This study identified that miR-372 was up-regulated by hypoxia in OSCC cells. The plasma level of miR-372 in OSCC patients significantly increased with the advance of OSCC. p62 is a multidomain protein that interacts with key components to drive diverse impacts on signaling regulation including detoxification pathway. Using in silico prediction modules, qRT-PCR analysis, Western blot analysis, reporter assay and exogenous expression construct, we discovered that p62 was a novel target of miR-372. Ectopic miR-372 expression and knockdown of p62 both enhanced the migration of OSCC cells, but it did not affect the proliferation of OSCC cells. Furthermore, we demonstrated that p62 was able to induce the expression of phase II enzyme NQO1, which resulted in the attenuation of reactive oxygen species and migration in OSCC cells. Furthermore, correlation among the expression of miR-372, p62 and NQO1 was found in OSCC tissues. This study concludes that hypoxia-induced miR-372 expression modulates the progression of OSCC by targeting p62, which disrupts the ROS homeostasis in tumor cells. Citation Format: Li-Yin Yeh, Shu-Chun Lin, Chung-Ji Liu, Yong-Kie Wong, Kuo-Wei Chang. Hypoxia-induced miR-372 targets p62 to affect the progression of oral carcinoma. [abstract]. In: Proceedings of the 105th Annual Meeting of the American Association for Cancer Research; 2014 Apr 5-9; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2014;74(19 Suppl):Abstract nr 4360. doi:10.1158/1538-7445.AM2014-4360
Abstract 3880: Targeting the root of cancer: a data-driven approach for identification of lung cancer stem cell biomarkers
Authors: Hua Fan-Minogue, Atul Butte
Journal: Cancer Research (2014)

Abstract Cancer stem cells (CSCs) are a small group of cancer cells with stem cell-like properties and have been revealed to be the drive force of tumorigenesis, metastasis and drug resistance in many cancers. Current CSC surface biomarkers, such as CD133, CD44 and CD166, have been used to isolate CSC population. However, they are often not specific and unassociated with tumor outcome. Here, we applied a data-driven approach to identify new and functional biomarkers of CSC. We systematically screened for genes whose expressions are statistically correlated with CSC surface biomarkers. Normalized DNA microarray data of 160 cases of squamous carcinoma and 33 cases of adenocarcinoma and 8 cases of normal lung were analyzed for association with CD133, CD44 and CD166 respectively. Multiple hypothesis testing was corrected with the false discovery rate (FDR) less than 1%. We find CD133, CD44 and CD166 each has a different set of statistically associated genes in either adeno or squamous subtypes. Moreover, correlated genes with each of the surface marker are different between adeno and squamous subtypes. Among the highly correlated receptor genes with CD133 in squamous subtype is a hormone receptor of the reproduction regulator oxytocin (OXTR, r=0.4276, p=1.699e-8). We experimentally validated the correlation between OXTR and CD133 in human lung cancer tissues and cell lines. Further with functional assays, we discovered a new role of OXTR in promoting the self-renewal and differentiation of lung CSC. Our study suggests highly heterogeneous molecular features of CSC in different lung cancer types and demonstrates that association studies of CSC surface markers can be applied to identify new CSC biomarkers, which can be potentially used for development of probes for CSC imaging and targeting. Citation Format: Hua Fan-Minogue, Atul Butte. Targeting the root of cancer: a data-driven approach for identification of lung cancer stem cell biomarkers. [abstract]. In: Proceedings of the 105th Annual Meeting of the American Association for Cancer Research; 2014 Apr 5-9; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2014;74(19 Suppl):Abstract nr 3880. doi:10.1158/1538-7445.AM2014-3880
Child Abuse
Authors: P. Nair
Journal: JAMA (2006)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Oral pathergy test in Behçet's disease
Authors: K.E. Sharquie, A. Al-Araji, A. Hatem
Journal: British Journal of Dermatology (2002)

Sir, The pathergy test (PT) is a diagnostic marker in Behçet's disease (BD). It shows a high positivity in countries where the disease is more prevalent, notably the Mediterranean basin, Middle East and Far East. The high prevalence of positive PTs among patients with BD and its negativity among controls led to inclusion of the PT in the International Study Group (ISG) criteria for diagnosis of BD.1 In previous studies, the PT was positive in 71% of Iraqi and 82% of Turkish patients.2, 3 In contrast, it is seldom positive among patients in Northern Europe or the U.S.A.4, 5 We tested a new method for performing the PT by pricking the mucosa of the lower lip, and compared it with the traditional skin test. Eighty‐three patients (65 men and 18 women; mean ± SD age 29·5 ± 6·4 years, range 16–58) who fulfilled the ISG criteria for diagnosis of BD1 were included in this prospective study. The patients attended a multidisciplinary BD clinic at Baghdad Teaching Hospital between April 1999 and July 2000. Controls comprised 90 healthy individuals (65 men and 25 women; mean ± SD age 24·3 ± 3·7 years) and 30 patients (22 men and eight women; mean ± SD age 31·4 ± 9·8 years) with other diseases: acne (n = 6), lichen planus (n = 5), psoriasis (n = 5), recurrent aphthous stomatitis (n = 4), pemphigus vulgaris (n = 4), rheumatoid arthritis (n = 3) and erythema multiforme (n = 3). All subjects were tested using both methods.
Welsh children's commissioner will have powers over hospitals
Authors: Roger Dobson
Journal: BMJ (2000)

The new children's commissioner for Wales is to have powers covering NHS hospitals. It was originally expected that the role of the commissioner, the first in the United Kingdom, would be concerned with children in care, but a new parliamentary bill to be published shortly is designed to expand significantly the brief to cover the NHS and schools.

Under the proposals in the bill, the newly appointed commissioner, Peter Clarke, will have a range of additional powers.

“The bill is expected to expand the commissioner's role by applying the …