tbuckley/cabot-search huggingface dataset:
Markers of health and disease and pigmented spots in a middle-aged population
Authors: K. van Drielen, D.A. Gunn, C.E.M. Griffiths, T.W. Griffiths, S. Ogden, R. Noordam, P.E. Slagboom, D. van Heemst, A.J.M. de Craen
Journal: British Journal of Dermatology (2015)

Journal Article Markers of health and disease and pigmented spots in a middle‐aged population Get access K. van Drielen, K. van Drielen Department of Gerontology and Geriatrics Leiden University Medical Center PO Box 9600 2300 RC Leiden the Netherlands Search for other works by this author on: Oxford Academic Google Scholar D.A. Gunn, D.A. Gunn Unilever R&D Sharnbrook Bedfordshire U.KNetherlands Consortium of Healthy Aging (NCHA) Leiden the Netherlands Search for other works by this author on: Oxford Academic Google Scholar C.E.M. Griffiths, C.E.M. Griffiths Dermatology Centre Salford Royal Hospital University of Manchester Manchester Academic Health Science Centre Manchester U.K Search for other works by this author on: Oxford Academic Google Scholar T.W. Griffiths, T.W. Griffiths Dermatology Centre Salford Royal Hospital University of Manchester Manchester Academic Health Science Centre Manchester U.K Search for other works by this author on: Oxford Academic Google Scholar S. Ogden, S. Ogden Dermatology Centre Salford Royal Hospital University of Manchester Manchester Academic Health Science Centre Manchester U.K Search for other works by this author on: Oxford Academic Google Scholar R. Noordam, R. Noordam Department of Gerontology and Geriatrics Leiden University Medical Center PO Box 9600 2300 RC Leiden the Netherlands Search for other works by this author on: Oxford Academic Google Scholar P.E. Slagboom, P.E. Slagboom Netherlands Consortium of Healthy Aging (NCHA) Leiden the NetherlandsSection of Molecular Epidemiology Department of Medical Statistics and Bioinformatics Leiden University Medical Center PO Box 9600 2300 RC Leiden the Netherlands Search for other works by this author on: Oxford Academic Google Scholar D. van Heemst, D. van Heemst Department of Gerontology and Geriatrics Leiden University Medical Center PO Box 9600 2300 RC Leiden the NetherlandsNetherlands Consortium of Healthy Aging (NCHA) Leiden the Netherlands Search for other works by this author on: Oxford Academic Google Scholar A.J.M. de Craen A.J.M. de Craen Department of Gerontology and Geriatrics Leiden University Medical Center PO Box 9600 2300 RC Leiden the NetherlandsNetherlands Consortium of Healthy Aging (NCHA) Leiden the Netherlands Correspondence: Anton J.M. de Craen. E‐mail: A.J.M.de_Craen@lumc.nl Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 173, Issue 6, 1 December 2015, Pages 1550–1552, https://doi.org/10.1111/bjd.14051 Published: 01 December 2015
Combining physical activity monitoring and cardiac output during exercise in COPD patients with GOLD stages II-IV
Authors: Eleni Kortianou, Ioannis Vogiatzis, Zafeiris Louvaris, Maroula Vasilopoulou, Ioannis Nasis, Vasilis Andrianopoulos, Theodora Vasilogiannakopoulou, Giorgos Kaltsakas, Manos Alchanatis, Nikolaos G. Koulouris
Journal: European Respiratory Journal (2011)

Background:  Daily physical activity recorded by activity monitors, is an important clinical outcome in COPD patients. However, it is unknown whether changes in physical activity data are related to changes in hemodynamic responses during exercise.   Aim:  To investigate whether changes in estimated energy expenditure (EE) by activity monitoring are associated with changes in cardiac output (CO) during exercise.   Methods:  30 COPD patients (10 for each GOLD stage:II,III,IV) undertook a standardized treadmill test including breath-by-breath gas exchange measurements. Cardiac haemodynamics was assessed by impedance cardiography. The SenseWear armband (SW) and the DynaPort Minimod (MM) were used to estimate EE. All patients exercised at 4 different velocities increasing by 0.7-0.8 km/h every 3 min. Minimum and maximum speeds were 1.4±0.3 km/h and 3.7±0.4 km/h, respectively. Minute-by-minute data were acquired and aligned for each patient.   Results:  CO was linearly increased with increasing speeds (r=0.97). Median and interquartile range of the correlation between CO and EE by SW and MM are shown below. The level of correlation between CO and EE was not different across GOLD stages and between the two activity monitors.   Conclusion:  Hemodynamic variations during incremental treadmill exercise in COPD were reliably reflected by changes in EE as those were recorded by the SenseWear armband and the Dynaport Minimod. Supported by IMI-JU Proactive#115011.
Central Nervous System Cancers
Authors: Louis Burt Nabors, Mario Ammirati, Philip J. Bierman, Henry Brem, Nicholas Butowski, Marc C. Chamberlain, Lisa M. DeAngelis, Robert A. Fenstermaker, Allan Friedman, Mark R. Gilbert, Deneen Hesser, Matthias Holdhoff, Larry Junck, Ronald Lawson, Jay S. Loeffler, Moshe H. Maor, Paul L. Moots, Tara Morrison, Maciej M. Mrugala, Herbert B. Newton, Jana Portnow, Jeffrey J. Raizer, Lawrence Recht, Dennis C. Shrieve, Allen K. Sills, David Tran, Nam Tran, Frank D. Vrionis, Patrick Y. Wen, Nicole McMillian, Maria Ho
Journal: Journal of the National Comprehensive Cancer Network (2013)

Primary and metastatic tumors of the central nervous system are a heterogeneous group of neoplasms with varied outcomes and management strategies. Recently, improved survival observed in 2 randomized clinical trials established combined chemotherapy and radiation as the new standard for treating patients with pure or mixed anaplastic oligodendroglioma harboring the 1p/19q codeletion. For metastatic disease, increasing evidence supports the efficacy of stereotactic radiosurgery in treating patients with multiple metastatic lesions but low overall tumor volume. These guidelines provide recommendations on the diagnosis and management of this group of diseases based on clinical evidence and panel consensus. This version includes expert advice on the management of low-grade infiltrative astrocytomas, oligodendrogliomas, anaplastic gliomas, glioblastomas, medulloblastomas, supratentorial primitive neuroectodermal tumors, and brain metastases. The full online version, available at NCCN. org, contains recommendations on additional subtypes.
THE SIGNIFICANCE OF JOINT PAINS CAUSED BY STERILE STREPTOCOCCUS TOXIN
Authors: Paul S. Rhoads, Melvin L. Afremow
Journal: Annals of Internal Medicine (1943)

Article1 July 1943THE SIGNIFICANCE OF JOINT PAINS CAUSED BY STERILE STREPTOCOCCUS TOXINPAUL S. RHOADS, M.D., F.A.C.P., MELVIN L. AFREMOW, M.D.PAUL S. RHOADS, M.D., F.A.C.P.Search for more papers by this author, MELVIN L. AFREMOW, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-19-1-60 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptIn 1937 Healey1reported that about 3 per cent of young adults being immunized against scarlet fever developed multiple joint pains as a reaction to one or more injections of the sterile filtrate of broth cultures of scarlet fever streptococci. She noted that the majority of persons who had this reaction gave a history of previous joint pains associated with rheumatic fever, or of streptococcus infections of the nose and throat. We had made similar observations. Healey showed that 74.6 per cent of a group of 63 such persons which she studied did not have joint pains when injected with...Bibliography1. HEALEY CE: The cause of joint pain occurring during immunization with scarlet fever streptococcus toxin, Jr. Am. Med. Assoc., 1937, cviii, 628. CrossrefGoogle Scholar2. COBURNPAULI AFRH: Studies in the immune response of the rheumatic subject and its relationship to activity of the rheumatic process. IV. Characteristics of strains of hemolytic streptococci effective and non-effective in initiating rheumatic activity, Jr. Clin. Invest., 1935, xiv, 766. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Evanston, Illinois*Delivered before the Regional Meeting of the American College of Physicians, Chicago, Ill., November 21, 1942.From the Department of Medicine, Northwestern University Medical School, and the Nurses' Infirmary of Cook County Hospital, Chicago. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byThe allergist's stake in collagen diseaseSerum electrophoretic pattern in experimental hypersensitivityRole of Dental Focal Infection in Etiology of DermatosisExperimental collagen disease from hypersensitization to streptococcus toxinThe Ætiology of Chronic RheumatismActive Immunization 1 July 1943Volume 19, Issue 1Page: 60-63KeywordsArthralgiaGroup A streptococciHospital medicinePharynxRheumatic feverScarlet feverStreptococcal infectionsStreptococcusToxinsYoung adults ePublished: 1 December 2008 Issue Published: 1 July 1943 PDF downloadLoading ...
Effect of a Cognitive-Behavioral Prevention Program on Depression 6 Years After Implementation Among At-Risk Adolescents
Authors: David A. Brent, Steven M. Brunwasser, Steven D. Hollon, V. Robin Weersing, Gregory N. Clarke, John F. Dickerson, William R. Beardslee, Tracy R. G. Gladstone, Giovanna Porta, Frances L. Lynch, Satish Iyengar, Judy Garber
Journal: JAMA Psychiatry (2015)

Adolescents whose parents have a history of depression are at risk for developing depression and functional impairment. The long-term effects of prevention programs on adolescent depression and functioning are not known.To determine whether a cognitive-behavioral prevention (CBP) program reduced the incidence of depressive episodes, increased depression-free days, and improved developmental competence 6 years after implementation.A 4-site randomized clinical trial compared the effect of CBP plus usual care vs usual care, through follow-up 75 months after the intervention (88% retention), with recruitment from August 2003 through February 2006 at a health maintenance organization, university medical centers, and a community mental health center. A total of 316 participants were 13 to 17 years of age at enrollment and had at least 1 parent with current or prior depressive episodes. Participants could not be in a current depressive episode but had to have subsyndromal depressive symptoms or a prior depressive episode currently in remission. Analysis was conducted between August 2014 and June 2015.The CBP program consisted of 8 weekly 90-minute group sessions followed by 6 monthly continuation sessions. Usual care consisted of any family-initiated mental health treatment.The Depression Symptoms Rating scale was used to assess the primary outcome, new onsets of depressive episodes, and to calculate depression-free days. A modified Status Questionnaire assessed developmental competence (eg, academic or interpersonal) in young adulthood.Over the 75-month follow-up, youths assigned to CBP had a lower incidence of depression, adjusting for current parental depression at enrollment, site, and all interactions (hazard ratio, 0.71 [95% CI, 0.53-0.96]). The CBP program's overall significant effect was driven by a lower incidence of depressive episodes during the first 9 months after enrollment. The CBP program's benefit was seen in youths whose index parent was not depressed at enrollment, on depression incidence (hazard ratio, 0.54 [95% CI, 0.36-0.81]), depression-free days (d = 0.34, P = .01), and developmental competence (d = 0.36, P = .04); these effects on developmental competence were mediated via the CBP program's effect on depression-free days.The effect of CBP on new onsets of depression was strongest early and was maintained throughout the follow-up period; developmental competence was positively affected 6 years later. The effectiveness of CBP may be enhanced by additional booster sessions and concomitant treatment of parental depression.clinicaltrials.gov Identifier:NCT00073671.
Computer aided lung sound analysis in smokers
Authors: Mohammed Alzahrani, Anne Bruton, Anna Barney
Journal: European Respiratory Journal (2012)

Computer technology was used to record and analyse lung sounds in two groups of healthy young subjects (smokers and non-smokers).   Introduction   Tobacco smoking is known to have adverse effects on human health. It is believed that smoking in early life has a substantial role in the development of chronic lung disease, but it is not yet known when the first measurable effects of smoking can be detected. Computer aided lung sound analysis (CALSA) permits the quantification of lung sounds, which may change in response to smoking related pathological processes. Crackles are one type of added lung sound which can be quantified using CALSA.   Method   Sixty male subjects (30 smokers and 30 non-smokers) aged 26.6 ± 4.7 years were recruited from a student population. Lung sound recordings were made using a digital stethoscope, following published guidelines. Sounds were recorded on a computer with Matlab software. Using signal processing techniques, one characteristic of the crackles was measured (namely the two cycle deflection (2CD)) at each anatomical recording site. Statistical analysis was used to quantify differences in crackles between smokers and non-smokers.   Findings   Sixty sets of data have been analysed. The 2CD per site data revealed some statistically significant differences at both anterior sites (anterior left: F (2, 57) = 9.40, P = 0.00; anterior right: F (2, 57) = 9.51, P = 0.00)) and both lateral sites (middle left: F (2, 57) = 4.2, P = 0.02; middle right: F (2, 57) = 4.36, P = 0.02)).   Conclusion   The hypothesis that lung crackle9s 2CD differ between asymptomatic smokers and non-smokers has been supported.
Interleukin-2-induced thyroid dysfunction is correlated with treatment duration but not with tumor response.
Authors: W H Kruit, R L Bolhuis, S H Goey, R L Jansen, A M Eggermont, D Batchelor, P I Schmitz, G Stoter
Journal: Journal of Clinical Oncology (1993)

PURPOSE To analyze the putative relationship between immunotherapy-associated dysthyroidism and the probability of a tumor response. PATIENTS AND METHODS A total of 89 consecutive patients with advanced cancer were treated with interleukin-2 (IL2)-based immunotherapy in a prospective study. RESULTS Twenty patients developed thyroid dysfunction. Repeatedly positive tests for thyroid antibodies developed in 28% of the patients. Twenty-two patients achieved a response. There was no relationship between the formation of antibodies and the probability of response. There appeared to be a trend toward a relationship between thyroid dysfunction and response (P = .23). A strong relationship was found between response on the one hand and cumulative dose of IL2 (P = .01) and treatment duration with IL2 (P = .025) on the other. The frequency of thyroid dysfunction was also significantly correlated with treatment duration (P = .001). After adjustment for cumulative dose of IL2 and treatment duration, no relationship between thyroid dysfunction and response remained (P = .99). CONCLUSION There is no relationship between thyroid dysfunction and the probability of tumor response. Thyroid dysfunction is merely a function of treatment duration and cumulative dose of IL2.
Immunohistochemical expression of Hsp27 and alphaB-crystallin in different histological subtypes of lung cancer
Authors: Dora Marinova, Yanina Slavova, Plamen Titorenkov, Vladimir Maksimov, Nedka Trifonova, Vladimir Djambazov, Maja Tafradjiiska, Danail Petrov
Journal: European Respiratory Journal (2012)

Aim: to evaluate the immunohistochemical expression of heat shock protein 27 (Hsp27) and alphaB-crystallin (Cryab) in resected lung cancers.  Methods: Surgically resected specimen from 105 patients (men n=72; women n=33, age 57± 12) with lung cancer were studied: carcinoid tumors(CT)-35, small cell lung carcinoma(SCLC)-20, large cell neuroendocrine carcinoma(LCNEC)-10, adenocarcinoma(AC)-20, and squamous cell carcinoma(SCC)-20. The histological subtype, pTNM stage, and the immunohistochemical expression of Hsp27 and Cryab were evaluated.  Results: The distribution in stages was as follows: CT-I stage-25(71%),II-7(20%),IIIA-3(9%); SCLC-I-7(35%), II-4(20%), IIIA-8(40%), IV-1(5%); LCNEC-I-4(40%),II-5(50%),III-10(10%); AC-I-8(40%),II-2(10%),III-10(50%); SCC-I-8(40%),II-1(5%),III-11(55%) (p 75% ot tumor cells),and in combination with nuclear expression in 46%. Nuclear expression was in: 100% of LCNEC,50%-SCLC and SCC,35%-AC, 29%-CT (p  Conclusion: low weight heat shock proteins play a major role in cancerogenesis of lung cancer, eventually has a prognostic value and may be used as targets for therapy.
Regulatory Variants for the Expression of H-2 Antigens. I. Isolation and Characterization2
Authors: T. V. Rajan, Stanley G. Nathenson, Matthew D. Scharff
Journal: JNCI Journal of the National Cancer Institute (1976)

By subjecting “mutagenized” mouse myeloma cells repeatedly to selection with antiserum against H-2Kd, we isolated variants that expressed little or no H-2Kd alloantigens. The phenotype was unstable, with the culture accumulating revertants in the absence of selective pressure. The variants not only failed to express the selected antigen, but also the antigen coded by the closely linked H-2Dd gene. The cells reexpressed this antigen with the same kinetics as for the selected antigen. Several physiologic parameters (karyotype, cell morphology, size, and growth curves) were not altered by the loss of H-2 antigens. However, when injected iv, the H-2-deficient cells did not lodge in the spleen as readily as did the wild-type cell.
Unexpectedly high prevalence of Treponema pallidum infection in the oral cavity of human immunodeficiency virus-infected patients with early syphilis who had engaged in unprotected sex practices
Authors: C.-J. Yang, S.-Y. Chang, B.-R. Wu, S.-P. Yang, W.-C. Liu, P.-Y. Wu, J.-Y. Zhang, Y.-Z. Luo, C.-C. Hung, S.-C. Chang
Journal: Clinical Microbiology and Infection (2015)
Prophylactic isolated limb perfusion for localized, high-risk limb melanoma: results of a multicenter randomized phase III trial. European Organization for Research and Treatment of Cancer Malignant Melanoma Cooperative Group Protocol 18832, the World Health Organization Melanoma Program Trial 15, and the North American Perfusion Group Southwest Oncology Group-8593.
Authors: H S Koops, M Vaglini, S Suciu, B B Kroon, J F Thompson, J Göhl, A M Eggermont, F Di Filippo, E T Krementz, D Ruiter, F J Lejeune
Journal: Journal of Clinical Oncology (1998)

PURPOSE Patients with primary cutaneous melanoma &gt; or = 1.5 mm in thickness are at high risk of having regional micrometastases at the time of initial surgical treatment. A phase III international study was designed to evaluate whether prophylactic isolated limb perfusion (ILP) could prevent regional recurrence and influence survival. PATIENTS AND METHODS A total of 832 assessable patients from 16 centers entered the study; 412 were randomized to wide excision (WE) only and 420 to WE plus ILP with melphalan and mild hyperthermia. Median age was 50 years, 68% of patients were female, 79% of melanomas were located on a lower limb, and 47% had a thickness &gt; or = 3 mm. RESULTS Median follow-up duration is 6.4 years. There was a trend for a longer disease-free interval (DFI) after ILP. The difference was significant for patients who did not undergo elective lymph node dissection (ELND). The impact of ILP was clearly on the occurrence-as first site of progression - of in-transit metastases (ITM), which were reduced from 6.6% to 3.3%, and of regional lymph node (RLN) metastases, with a reduction from 16.7% to 12.6%. There was no benefit from ILP in terms of time to distant metastasis or survival. Side effects were higher after ILP, but transient in most patients. There were two amputations for limb toxicity after ILP. CONCLUSION Prophylactic ILP with melphalan cannot be recommended as an adjunct to standard surgery in high-risk primary limb melanoma.
Norepinephrine and <i>N</i> <sup>ω</sup>-Monomethyl-<scp>l</scp>-arginine in Porcine Septic Shock
Authors: KARL TRäGER, PETER RADERMACHER, KAREN M. RIEGER, ARNIM VLATTEN, JOSEF VOGT, THOMAS IBER, JENS ADLER, ULRICH WACHTER, ROBERT GROVER, MICHAEL GEORGIEFF, BORISLAV SANTAK
Journal: American Journal of Respiratory and Critical Care Medicine (1999)

We compared the effects of norepinephrine (NOR; n = 11) and the nonselective nitric oxide synthase inhibitor N ω-monomethyl-l-arginine (l-NMMA; n = 11) on hepatic blood flow (Q˙ liv), O2 exchange, and energy metabolism over 24 h of hyperdynamic, normotensive porcine endotoxic shock. Endotoxin (ETX; n = 8) caused a continuous fall in mean arterial pressure (MAP) despite a sustained 50% increase in cardiac output (Q˙) achieved by adequate fluid resuscitation. NOR maintained MAP at preshock levels owing to a further rise in Q˙, while the comparable hemodynamic stabilization during l-NMMA infusion resulted from systemic vasoconstriction, increasing the systemic vascular resistance (SVR) about 30% from shock level after 6 h of treatment concomitant with a reduction in Q˙ to preshock values. Whereas NOR also increased Q˙ liv and, hence, hepatic O2 delivery (hDo 2), but did not affect hepatic O2 uptake (hVo 2), l-NMMA influenced neither Q˙ liv nor hDo 2 and hVo 2. Mean capillary hemoglobin O2 saturation (HbScO2 ) on the liver surface as well as HbScO2 frequency distributions, which mirror microcirculatory O2 availability, remained unchanged as well. Neither treatment influenced the ETX-induced derangements of cellular energy metabolism reflected by the progressive decrease in hepatic lactate uptake rate and increased hepatic venous lactate / pyruvate ratios. ETX nearly doubled the endogenous glucose production (EGP) rate, which was further increased with NOR, whereas l-NMMA nearly restored EGP to preshock levels. Nevertheless, despite the different mechanisms in maintaining blood pressure neither treatment influenced ETX-induced liver dysfunction.
Immunofluorescent Studies of Mouse and Hamster Cell Surface Antigens Induced by Polyoma Virus
Authors: Richard A. Malmgren, Kenneth K. Takemoto, Paula G. Carney
Journal: JNCI Journal of the National Cancer Institute (1968)

The surface antigens of mouse and hamster polyoma-induced tumor cells and of mouse cells in the lytic cycle of polyoma virus infection were studied with the indirect fluorescent-antibody technique. Sera of mice immunized with polyoma virus or polyoma tumor cells were examined. Reactions were observed between the various sera and polyoma-transformed mouse and hamster cells or mouse cells in the lytic cycle. No reaction was noted with normal mouse embryo cells, simian virus 40-transformed mouse or hamster cells, or with mouse cells infected with herpesvirus. In addition, control sera from mice immunized with simian virus 40, a methylcholanthrene-induced tumor, or a mammary tumor failed to react with the polyoma-transformed cells.