THE INFLUENCE OF OVARIAN ACTIVITY AND ADMINISTERED ESTROGENS UPON DIABETES MELLITUS: CASE REPORT
Authors: J H MORTON, T H McGAVACK
Journal: Annals of Internal Medicine (1946)

Case Reports1 July 1946THE INFLUENCE OF OVARIAN ACTIVITY AND ADMINISTERED ESTROGENS UPON DIABETES MELLITUS: CASE REPORTJOSEPH H. MORTON, M.D., THOMAS H. MCGAVACK, M.D., F.A.C.P.JOSEPH H. MORTON, M.D.Search for more papers by this author, THOMAS H. MCGAVACK, M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-25-1-154 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptMuch time and effort have been spent in the study of the probably complex interrelationship existing between the anterior pituitary and the pancreatic islets in their regulation of carbohydrate metabolism. Many points are still obscure. However, there is evidence for an over-all antagonistic action between the hypophysis and the islets of Langerhans which is well supported by the following data.Hypophysectomy results in a marked improvement in the diabetic state of depancreatized animals,1, 2and permanent diabetes can be induced by injecting extracts from the anterior pituitary.3, 4, 5, 6, 7These facts indicate that a diabetogenic principle is formed...Bibliography1. HOUSSAYBIASOTTI BAA: The hypophysis, carbohydrate metabolism and diabetes, Endocrinology, 1931, xv, 511. CrossrefGoogle Scholar2. REGANBARNES JFBO: The relation of the hypophysis to experimental diabetes, Science, 1933, lxxvii, 214. CrossrefGoogle Scholar3. YOUNG FG: Permanent experimental diabetes produced by pituitary (anterior lobe) injections, Lancet, 1937, ii, 372. CrossrefGoogle Scholar4. EVANSMEYERSIMPSONREICHERT HMKMEFL: Disturbance of carbohydrate metabolism in normal dogs injected with the hypophyseal growth hormone, Proc. Soc. Exper. Biol. and Med., 1931-32, xxix, 857. Google Scholar5. NELSONOVERHOLSER WOMD: Effect of oestrin injections upon experimental pancreatic diabetes in the monkey, Proc. Soc. Exper. Biol. and Med., 1934-35, xxxii, 150. CrossrefGoogle Scholar6. HOUSSAY BA: Diabetes as a disturbance of endocrine regulation, Am. Jr. Med. Sci., 1937, cxvii, 581. Google Scholar7. YOUNG FG: The anterior pituitary gland and diabetes mellitus, New Eng. Jr. Med., 1939, ccxxi, 635. CrossrefGoogle Scholar8. BARNESREGANNELSON BOJFWO: Improvement in experimental diabetes following administration of amniotin, Jr. Am. Med. Assoc., 1933, ci, 926. CrossrefGoogle Scholar9. SPENCERD'ARMOURGUSTAVSON JFERG: Further studies on estrinhypophyseal antagonism in the white rat, Endocrinology, 1932, xvi, 647. CrossrefGoogle Scholar10. MEYERLEONARDHISAWMARTIN RKSLFLSJ: The influence of estrin on the gonad-stimulating complex of the anterior pituitary of castrated male and female rats, Endocrinology, 1932, xvi, 655. CrossrefGoogle Scholar11. ZONDEK B: The inhibitory effect of follicular hormone on the anterior lobe of the pituitary gland, Lancet, 1936, i, 10. CrossrefGoogle Scholar12. ZONDEK B: Impairment of anterior pituitary functions by follicular hormone, Lancet, 1936, ii, 842. CrossrefGoogle Scholar13. MAZERISRAELRAVETZ DSLE: The synthetic estrogen stilbestrol, Jr. Am. Med. Assoc., 1941, cxvi, 675. CrossrefGoogle Scholar14. HEPP JK: Stilbestrol: A clinical and investigational study, Pennsylvania Med. Jr., 1941, xliv, 718. Google Scholar15. WINTERTONMACGREGOR WRTN: Clinical observations with stilbestrol, Brit. Med. Jr., 1939, i, 10. CrossrefGoogle Scholar16. CONNALLYDANNREESEDOUGLASS HFDIJMLH: A clinical study of the effects of diethylstilbestrol on puerperal women, Am. Jr. Obst. and Gynec., 1940, xl, 445. CrossrefGoogle Scholar17. MUCKLE CW: The suppression of lactation by stilbestrol, Am. Jr. Obst. and Gynec., 1940, xl, 133. CrossrefGoogle Scholar18. CANTILO E: Successful responses in diabetes mellitus of the menopause produced by the antagonistic action of sex hormones on pituitary activity, Endocrinology, 1941, xxviii, 20. CrossrefGoogle Scholar19. GOLDMANGOLDMANKURZROCK SFAR: The treatment of menopausal hyperthyroidism with estrogenic substance, N. Y. State Jr. Med., 1940, xl, 1178. Google Scholar20. KAUFMANN E: Ovarialhormon, Insulin und Kohlenhydratstoffwechsel, Deutsche med. Wchnschr., 1929, lv, 650. CrossrefGoogle Scholar21. GULICKSAMUELSDUEUL MLTHJ: The sexual variation in carbohydrate metabolism, Jr. Biol. Chem., 1934, cv, 29. CrossrefGoogle Scholar22. YOUNG FG: Influence of estrogens on experimental canine diabetes mellitus, Lancet, 1941, i, 600. CrossrefGoogle Scholar23. COLLENSSLOBODKINROSENBLIETTBOAS WSSGSLC: The effect of estrogenic substance on human diabetes, Jr. Am. Med. Assoc., 1936, cvi, 678. CrossrefGoogle Scholar24. ZUNZLABARRE EJ: Contributions a l'etude des effets des hormones sexuelles sur la regulation de la glycemie, Arch. Internat. de Physiol., 1939, xlviii, 287. Google Scholar25. INGLE DI: Diabetogenic effect of stilbestrol in force-fed normal and partially depancreatized rats, Endocrinology, 1941, xxix, 838. CrossrefGoogle Scholar26. DOLINJOSEPHGAUNT GSR: Effect of steroid and pituitary hormones on experimental diabetes mellitus of ferrets, Endocrinology, 1941, xxviii, 840. CrossrefGoogle Scholar27. GRIFFITHSMARKSYOUNG MHPFC: Influence of estrogens and androgens on glycogen storage in fasting rat, Nature, London, 1941, i, 601. Google Scholar28. LAWRENCEMADDERS RDK: Human diabetes treated with estrogens, Lancet, 1941, i, 601. CrossrefGoogle Scholar29. MAZERISRAEL CSL: Studies on the optimal dosage of estrogens, Jr. Am. Med. Assoc., 1937, cviii, 163. CrossrefGoogle Scholar30. GESSLERHALSTEDSTETSON CJJARP: The effect of estrogenic substance on the blood sugar of female diabetics after the menopause, Jr. Clin. Invest., 1939, xviii, 715. CrossrefGoogle Scholar31. SPIEGELMAN AR: Influence of estrogen on the insulin requirement of a diabetic, Am. Jr. Med. Sci., 1940, cc, 228. CrossrefGoogle Scholar32. GITLOWKURSCHNER SDM: Estrogen, diabetes, and the menopause, Arch. Int. Med., 1943, lxxii, 250. CrossrefGoogle Scholar33. LUKENSDOHAN FDFC: Remissions of diabetes mellitus, Pennsylvania Med. Jr., 1944, xlvii, 1. Google Scholar34. FRANKGOLDBERGER RTMA: The female sex hormone, its occurrence in the circulating and menstrual blood of the human female, Jr. Am. Med. Assoc., 1926, lxxxvi, 1686. CrossrefGoogle Scholar35. FLUHMAN CF: A new procedure for the demonstration of estrin in the blood of women, Endocrinology, 1934, xviii, 705. CrossrefGoogle Scholar36. PALMER A: Hormones in urine of a normal non-pregnant woman, Proc. Soc. Exper. Biol. and Med., 1937-38, xxxvii, 273. CrossrefGoogle Scholar37. YERBY LD: Relation of urinary excretion of estrone to menstrual cycle of normal women, Proc. Soc. Exper. Biol. and Med., 1937, xxxvi, 496. CrossrefGoogle Scholar38. GUSTAVSONGREEN RGDR: The quantitative determination of the amount of estrogenic substances excreted daily in the urine of the normal female, Jr. Biol. Chem., 1934, cv, 24. Google Scholar39. SMITHSMITH GVOW: Quantitative determination of urinary oestrin, Am. Jr. Physiol., 1935, cxii, 340. CrossrefGoogle Scholar40. D'AMOUR FE: The estrin-gonadotropin relationship during the menstrual cycle, Am. Jr. Physiol., 1940, cxxix, 342. Google Scholar41. GUSTAVSONMASONHAYSWOODD'ARMOUR RGLWEETRFE: The quantitative determination of estrogenic substances in normal female urine during the menstrual cycle, Am. Jr. Obst. and Gynec., 1938, xxxv, 115. CrossrefGoogle Scholar42. WERNER SC: A quantitative study of the urinary excretion of hypophyseal gonadotropin, estrogen, and androgen of normal women, Jr. Clin. Invest., 1941, xx, 21. CrossrefGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: New York, N. Y.*Received for publication May 21, 1945.From the Department of Medicine, New York Medical College, and the Endocrine Service, Metropolitan Hospital, New York, N. Y. 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