tbuckley/cabot-search huggingface dataset:
Photoactivation of porphyrins: studies of reactive oxygen intermediates and arrhythmogenesis in the aerobic rat heart
Authors: Y. Kusama, M. Bernier, D. J Hearse
Journal: Cardiovascular Research (1990)

Study objective – In situ production of reactive oxygen intermediates (singlet oxygen and superoxide) during the photoactivation of rose bengal can induce arrhythmias in the aerobically perfused rat heart. The present study was undertaken (1) to assess whether these effects occur with other photosensitisers; (2) to identify the injurious intermediates; (3) to probe the site of action of these phenomena. Design – The study involved the use of meso-tetra- (4-sulphonatophenyl)-porphine (TPPS), a porphyrin which, in contrast to rose bengal, promotes the production of singlet oxygen alone when illuminated, After 10 min of TPPS free perfusion, rat hearts (n = 6 per group) were perfused aerobically with TPPS (1,5,10 or 50 μmol·litre−1) for 25 min; during the last 20 min, the hearts were illuminated (3600 lux). In additional studies, TPPS (50 μmol·litre−1) was washed out before illumination. Experimental material – Hearts from 30 male Wistar rats, weighing 220-280 g, were excised and perfused retrogradely. Measurements and main results – Cardiac function was unaffected with TPPS alone. Upon illumination, electrocardiographic changes (increase in QT interval andor T wave changes) and arrhythmias developed in a dose dependent manner. At the highest dose, electrocardiographic changes occurred within 7.0(SEM 0.4) s; all hearts exhibited ventricular premature beats and complete atrioventricular block; 67% developed ventricular tachycardia and 17% ventricular fibrillation. During illumination, hearts also exhibited a dose and time dependent decrease in coronary flow. In additional studies, despite the absence of TPPS in the perfusate, all hearts exhibited complete atrioventricular block, 67% developed ventricular premature beats and 33% ventricular tachycardia; none exhibited ventricular fibrilla tion. Conclusions – The results suggest that singlet oxygen, as opposed to superoxide, is responsible for the injury which occurs at tissue surfaces to which photosensitiser is bound.
A Replication Study Validates The Association Of 14 Snps In 11 Genes With Chronic Rhinosinusitis With Nasal Polyposis
Authors: L. Mfuna Endam, A. Filali-Mouhim, P. Boisvert, L. Boulet, Y. Bossé, M. Desrosiers
Journal: Journal of Allergy and Clinical Immunology (2011)
Prognostic Importance of Elevated Jugular Venous Pressure and a Third Heart Sound in Patients with Heart Failure
Authors: Mark H. Drazner, J. Eduardo Rame, Lynne W. Stevenson, Daniel L. Dries
Journal: New England Journal of Medicine (2001)

The independent prognostic value of elevated jugular venous pressure or a third heart sound in patients with heart failure is not well established.
India's hunger rating falls to reflect drop in underweight prevalence
Authors: C. Travasso
Journal: BMJ (2014)

India’s global hunger index has been downgraded from “alarming” to “serious,” reflecting a fall in undernourishment in the population, figures from the International Food Policy Research Institute, a non-profit research organisation based in Washington, DC, have shown.

The global hunger index is a 100 point scale (where 0 represents no hunger) that takes into account …
Examination of the Larynx
Authors: Robert J. Toohill
Journal: JAMA (1982)

To the Editor.—  In his article Why Can't Physicians Examine the Larynx? Dr Klein focused attention on the primary physician's inability to perform routine mirror or  examination of the larynx. He emphasized the importance of this portion of the physical evaluation, particularly when the patient has laryngeal symptoms, and recommended that  laryngoscopy be taught in our medical schools. As a teacher of students and residents for the past 17 years, I applaud Dr Klein's efforts to bring this to the attention of all in the medical community. The incidence of cancers of the larynx and hypopharynx are indeed on the rise, and their early detection is vital for success in therapy. However, I feel that his statement that telescopic laryngscopy is a skill that requires no great proficiency and can be learned from simple demonstration at one sitting does not coincide with my teaching experience. Since I started
Cephalosporin Resistance in Neisseria gonorrhoeae Infections—Reply
Authors: Robert D. Kirkcaldy, Gail A. Bolan, Judith N. Wasserheit
Journal: JAMA (2013)

In Reply: We agree with Drs Klausner and Kerndt that antibiotic stewardship is an important component of controlling antibiotic resistance, and we support such efforts as sound clinical and public health practice.For many bacterial pathogens, antibiotic consumption appears to promote the emergence of resistance, and judicious antibiotic use may reduce the prevalence of resistance.
Inosine: a protective agent in an organ culture model of myocardial ischemia.
Authors: S Z Goldhaber, G M Pohost, R A Kloner, E Andrews, J B Newell, J S Ingwall
Journal: Circulation Research (1982)

Fetal mouse hearts in organ culture provide a model of ischemic-like injury in which the myocardial protective effect of pharmacological agents can be studied independent of blood flow. To investigate the potential protective effect of a diffusable purine under ischemic-like conditions, we used 4 mM inosine in fetal mouse heart organ cultures deprived of oxygen and oxidizable substrates for 1-10 hours. We studied hearts (n = 258) immediately after simulated ischemia (early) and after a 20-hour recovery period (late), by utilizing three indices of myocardial viability. Thallium-201 accumulation is an early marker of myocardial viability during injury, whereas the percentage of lactic dehydrogenase release from hearts to culture medium and the percentage of irreversibly injured myocytes assessed by planimetry of midventricular histological sections are late markers, used after recovery from injury. At 10 hours of injury, thallium-201 accumulation was 38% greater in inosine-supplied hearts, 3.50 +/- 0.16 vs. 2.54 +/- 0.08 (counts/min per mg wet weight)/(counts/min per microliter medium) (mean +/- SEM) (P less than 0.001). After recovery from 10 hours of injury, lactic dehydrogenase release was 29% less in inosine-supplied hearts, 35 +/- 3% vs. 49 +/- 3% (P less than 0.001). After recovery from 8 hours of injury, the percentage of histologically irreversibly injured tissue was 23% less in inosine-supplied hearts, 60 +/- 7% vs. 78 +/- 3% (P less than 0.05). These data indicate that inosine has a protective effect on fetal mouse myocardium during simulated ischemia and suggest that inosine deserves further evaluation.
Poor Labeling of Tc-99m Red Blood Cells In Vivo in a Radionuclide Intestinal Bleeding Study of a Patient Who Had Recently Undergone Frequent Blood Transfusions
Authors: Joji Kawabe, Shigeaki Higashiyama, Kenji Torii, Terue Okamura, Jin Kotani, Etsushi Kawamura, Hirotaka Ishizu, Koichi Koyama, Takahisa Yamane, Susumu Shiomi
Journal: Clinical Nuclear Medicine (2003)

The authors report poor labeling of Tc-99m red blood cells (RBCs) in vivo in a radionuclide intestinal bleeding study of a patient who had recently undergone frequent blood transfusions. The existence of RBC antibodies, as a result of the recent blood transfusions in this patient, was one of the causes of the poor labeling. In radionuclide bleeding studies with patients with recent blood transfusion, Tc-99m HSA-D must be chosen instead of Tc-99m RBCs in vivo.
IMPACT OF MULTI-SLICE COMPUTED TOMOGRAPHY IN EVALUATING MICRO-CHANNELS IN CORONARY CHRONIC TOTAL OCCLUSION LESIONS PRIOR TO PERCUTANEOUS CORONARY INTERVENTION
Authors: Masashi Kimura, Takahiko Suzuki, Etsuo Tsuchikane, Yoshihisa Kinoshita, Mitsuyasu Terashima, Tatsuya Ito, Kenya Nasu, Nobuyoshi Tanaka, Maoto Habara
Journal: Journal of the American College of Cardiology (2012)
TCTAP A-071 Clinical Outcomes of Multivessel Coronary Intervention in Octogenarians Hospitalized for Acute Coronary Syndrome: Comparisons with Younger Counterparts
Authors: Mohammad Arifur Rahman, Afzalur Rahman, Mohammad Mahbubur Rahman, Mohsin Ahmed, Abdul Momen, Farhana Ahmed, Rajib Gosh
Journal: Journal of the American College of Cardiology (2015)
<i>Racer’s Pillow</i>
Authors: Thomas B. Cole
Journal: JAMA (2013)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Recurrent loss of consciousness
Authors: J. Cooke, S. Carew, A. Costello, T. Sheehy, D. Lyons
Journal: BMJ (2008)

An electrocardiograph and beat-to-beat blood pressure recordings were performed during right sided supine carotid sinus massage on a 78 year old man (figure)⇓. He reported frequent episodes of loss of consciousness, which were typically of sudden onset followed within minutes by rapid recovery to full health. Some were associated with jerking movements of his limbs. He linked some of these episodes to turning his head. He had no important comorbidities but had recently fallen and sustained a fracture. Simultaneous beat-to-beat blood pressure (above) and electrocardiograph (below) tracings performed during right sided supine carotid sinus massage. Arrow indicates onset of 5 second carotid sinus massage. Image created with BeatScope software, using data obtained from a Finometer device ### Short answers
In vitro studies on the T-lymphocyte population of human milk.
Authors: M J Parmely, A E Beer, R E Billingham
Journal: The Journal of Experimental Medicine (1976)

Human milk lymphocytes (ML) can be partially purified and propagated in vitro as a means of assessing their immunological function. When exposed to a variety of stimuli known to activate T lymphocytes, ML respond in a unique manner that indicates a selected population of immunocompetent cells. ML are hyporesponsive to to nonspecific mitogens and respond in a reduced manner to histocompatibility antigens on allogeneic cells. In most cases, they are completely unresponsive to C. albicans although blood lymphocytes from the same patients respond to the antigen. The Kl capsular antigen of E. coli induces significant proliferation in lymphocytes obtained from milk, but fails to stimulate blood lymphocytes. This dichotomy of reactivity does not appear to result from suppressive factors or cells in milk or insufficient adherent cell function. Rather it appears to reflect the accumulation of particular lymphocyte clones in the breast and the local nature of mammary tissue immunity at the T-lymphocyte level.
Alterations in Plasma Lipids in the Presence of Mild Glucose Intolerance in the Offspring of Two Type II Diabetic Parents
Authors: Om P Ganda, J Stuart Soeldner, Ray E Gleason
Journal: Diabetes Care (1985)

Plasma lipids and oral glucose tolerance were determined in 67 normal control subjects (age range 19–67 yr) and 150 individuals (17–69 yr) who were offspring of two type II diabetic parents. Age- and weight-adjusted analyses of covariance were performed for lipids and for glucose and insulin responses. For both men and women, the mean concentrations of total, low-density-, and high-density-lipoprotein-cholesterol and of triglycerides in the offspring with normal glucose tolerance (N = 109) were similar to respective controls. For offspring with abnormal glucose tolerance (N = 41), the mean levels of total cholesterol, LDL-cholesterol, and triglycerides were significantly elevated (P = 0.02 or less) in women but not in men. The mean HDL-cholesterol levels were 20% lower and LDL/HDL-cholesterol ratios 60% greater in women with abnormal glucose tolerance, whereas no significant differences existed for any of the lipid fractions in men, compared with respective controls. Both men and women with abnormal glucose tolerance had a comparable magnitude of hyperglycemia as well as hyperinsulinemia. These observations indicate that significant alterations in plasma lipids exist in individuals with mild, asymptomatic glucose intolerance and there are important sex differences in lipid metabolism in the early stage of diabetes, despite comparable degrees of glucose intolerance and insulin responses.
Case of Suspected Poisoning by Oxalic Acid or its Salts: Recovery: With Remarks
Authors: T. Skinner
Journal: BMJ (1860)

principle is readily taken up by the spirit.The absolute alcohol is for that reason also preferable to the diluted.11. Wine of Sanguinaria.It is prepared in the same manner as the officinal tincture, substituting sherry wine for the diluted alcohol.The dose is the same as the tincture, and is considered more pleasant and powerful.12. Vinegar of Sanguinaria.Take of sanguinaria fresh and sliced, half an ounce; vinegar, two pints.Shake it fre- qluently, and it is ready for use in a few hours.This is the process of Dr. Jennings.I think it preferable to recommend the root to be bruised, and rubbed up with tlle vinegar, and filtered after a few hours.13. Syrup of Sanguinaria is prepared by Wiegand as follows:-Take of bloodroot in coarse powder, eight ounces; acetic acidl, four ounces; water, five pints; sugar, two pounds.Add to the powder two fluidounces of the acetic acid, mixed with a pint of the water; macerate for three days, transfer to a percolator, and displace with the remainder of the water mixed with the remainder of the acetic acid.Evaporate the infusion obtained, by means of a water-bath, to eighteen fluidounces, then add the sugar, and form] a syrup, straining, if necessary.This is serviceable to young childien.The dose, as an emetic, is fiom one to two fluiddlrachlms.14. Ointment of Sanguinaria.Take of the powdered root a drachm; lard, an ounce.Mix. 15.Sanguinarina.This is the alkaloid, and has not been used in medicine; I have prescribed some of the salts of it, prepared by myself. CASE OF SUSPECTED POISONING BY OXALICACID OR ITS SALTS: RECOVERY:* In December 1857 (or two years ago), I applied six leeches to the os uteri of the same patient, none of which died for months afterwards.
Visual Function in Young IDDM Patients Over 8 Years of Age: A 4-year longitudinal study
Authors: Rachel V North, Una Farrell, Denise Banford, Colin Jones, John W Gregory, Gary Butler, David R Owens
Journal: Diabetes Care (1997)

OBJECTIVE To carry out a longitudinal study of visual functions in young patients over the age of 8 years with IDDM and to assess the impact of metabolic control on the presence of diabetic retinopathy. RESEARCH DESIGN AND METHODS There were 37 young IDDM patients from the Paediatric and Adolescent Clinic at the University Hospital of Wales studied annually for 4 years, with a control group of 24 healthy subjects observed over a 2-year period. Assessment of visual functions included visual acuity, color vision, and contrast sensitivity. Ophthalmoscopy and retinal photography were used to determine the presence or absence of diabetic retinopathy. In addition, pubertal status and metabolic control (glycosylated hemoglobin) were determined at each visit. RESULTS Patients with IDDM demonstrate abnormal color vision and contrast sensitivity compared with the control group (P &amp;lt; 0.05), but visual acuity was unaffected. Visual functions were not significantly different between those IDDM patients with and without retinopathy. After 4 years, diabetic retinopathy was present in 43% of the group and was related to diabetes duration and metabolic control (P &amp;lt; 0.05). CONCLUSIONS Visual function testing could not distinguish between those IDDM patients with and without retinopathy, but the color vision and contrast sensitivity in those with IDDM were significantly impaired compared with the control group. The presence of retinopathy was related to the duration of diabetes and metabolic control. It is important to ensure that good glycemic control and regular attendance for retinopathy screening is encouraged in the adolescent patients.
Growth factors: Edited by J K Heath. (Pp 75; 8.95.) Oxford: IRL Press, 1993. ISBN 0-19-963041-0
Authors: K. H Banner
Journal: Cardiovascular Research (1995)

Journal Article Growth factors: Edited by J K Heath. (Pp 75; £8.95.) Oxford: IRL Press, 1993. ISBN 0-19-963041-0 Get access Katharine H Banner Katharine H Banner London, UK Search for other works by this author on: Oxford Academic PubMed Google Scholar Cardiovascular Research, Volume 29, Issue 3, March 1995, Page 440, https://doi.org/10.1016/S0008-6363(95)90026-8 Published: 01 March 1995
Cognitive Function in Preterm Infants
Authors: Glen P. Aylward
Journal: JAMA (2003)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Journals JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Hepatitis C virus infection and incident type 2 diabetes
Authors: Shruti H. Mehta, Frederick L. Brancati, Steffanie A. Strathdee, James S. Pankow, Dale Netski, Josef Coresh, Moyses Szklo, David L. Thomas
Journal: Hepatology (2003)

Although hepatitis C virus (HCV) infection is more common among adults with type 2 diabetes, it is uncertain whether HCV precedes the development of diabetes. Thus, we performed a prospective (case-cohort) analysis to examine if persons who acquired type 2 diabetes were more likely to have had antecedent HCV infection when enrolled in a community-based cohort of men and women between the ages of 44 and 65 in the United States (Atherosclerosis Risk in Communities Study [ARIC]). Among 1,084 adults free of diabetes at baseline, 548 developed diabetes over 9 years of follow-up evaluation. Incident cases of diabetes were identified by using fasting glucose and medical history and HCV antibodies were assessed at baseline. A priori, persons were categorized as low-risk or high-risk for diabetes based on their age and body mass index, factors that appeared to modify the type 2 diabetes-HCV infection incidence estimates. The overall prevalence of HCV in this population was 0.8%. Among those at high risk for diabetes, persons with HCV infection were more than 11 times as likely as those without HCV infection to develop diabetes (relative hazard, 11.58; 95% confidence interval, 1.39-96.6). Among those at low risk, no increased incidence of diabetes was detected among HCV-infected persons (relative hazard, 0.48; 95% confidence interval, 0.05-4.40). In conclusion, pre-existing HCV infection may increase the risk for type 2 diabetes in persons with recognized diabetes risk factors. Additional larger prospective evaluations are needed to confirm these preliminary findings.
Intraabdominal abscesses due to azathioprine for Crohn's disease
Authors: T. C. Northfield, C. I. Roberts
Journal: Gut (1972)

We report here a case of Crohn9s disease in which there is strong circumstantial evidence that azathioprine precipitated the development of an intraabdominal abscess on two separate occasions. On both occasions, the abscess developed within a few weeks of the patient starting azathioprine, and complete healing occurred on stopping azathioprine. The patient had never previously had this complication. On both occasions, the only early indications of a developing infection were the appearance of toxic granulation of neutrophils in the peripheral blood and a progressively rising erythrocyte sedimentation rate.
Poor biologic activity of cross-reactive IgE directed to carbohydrate determinants of glycoproteins
Authors: Mauritis J. van der Veen, Ronald van Ree, Rob C. Aalberse, Jaap Akkerdaas, Stef J. Koppelman, Henk M. Jansen, Jaring S. van der Zee
Journal: Journal of Allergy and Clinical Immunology (1997)
Informal Caregiving Burden in Advanced Non-small Cell Lung Cancer: The HABIT study
Authors: Cesare Gridelli, Carmine Ferrara, Ciro Guerriero, Salvatore Palazzo, Giuseppe Grasso, Ida Pavese, Francesco Satta, Emilio Bajetta, Diego Cortinovis, Fausto Barbieri, Vittorio Gebbia, Francesco Grossi, Silvia Novello, Editta Baldini, Giampietro Gasparini, Walter Latino, Emilia Durante, Lucio Giustini, Cristina Negrini
Journal: Journal of Thoracic Oncology (2007)
Atypical FTA-ABS Test Fluorescence in Lupus Erythematosus
Authors: F. Jennis
Journal: JAMA (1971)

<h3>To the Editor.—</h3> The interesting preliminary communication "Atypical FTA-ABS Test Fluorescence in Lupus Erythematosus Patients" (<b>211:</b>2140, 1970) brings to mind a similar experience in our laboratory. In September 1968, a 26-year-old married woman with two children presented herself at Sydney Hospital complaining of arthritis of five months' duration, and a severe upper respiratory tract infection of five weeks' duration. Clinical and laboratory examination confirmed a diagnosis of disseminated lupus erythematosus. The patient was treated with prednisone, 60 mg/day; but, after a rather stormy course which included a number of episodes of pericarditis and hypotension, the patient died in November 1968. Three serum samples from this patient were collected during September, and examined by the fluorescent treponemal antibody-absorption (FTA-ABS) test and other serological tests for syphilis. The FTA-ABS test revealed an atypical "beaded" pattern of spirochete fluorescence with all serum samples from this patient. The fluorescence was as bright as
Protein-Calorie Malnutrition in a Community Hospital
Authors: Mervyn D. Willard
Journal: JAMA (1980)

An assessment of protein-calorie status was performed on 200 consecutive adult nonobstetric admissions to a private hospital from two group family practices. Anthropometric measurements, serum albumin level, and total lymphocyte count were determined at admission and weekly if the patient remained in the hospital. Nonnutritional factors affecting muscle protein stores and serum albumin level were taken into account. A total of 63 patients (31.5%) were found to be malnourished. The most common conditions associated with decreased protein stores were hypoxic cardiopulmonary disease, gastrointestinal disease, neuromuscular or arthritic impairment, organic brain syndrome, and febrile illness. Although nonnutritional factors accounted for many instances of protein depletion, especially milder degrees of depletion, nevertheless protein calorie malnutrition was highly prevalent in this population. (<i>JAMA</i>243:1720-1722, 1980)