EXCESS URINARY CATECHOL AMINES WITHOUT PHEOCHROMOCYTOMA
Authors: B MALBIN
Journal: Annals of Internal Medicine (1959)

Case Reports1 September 1959EXCESS URINARY CATECHOL AMINES WITHOUT PHEOCHROMOCYTOMABARNEY MALBIN, M.D.BARNEY MALBIN, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-51-3-613 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptAbout eight years ago Engel and von Euler1 suggested that the quantitative determination of the catechol amines in the urine might be a practical procedure for the diagnosis of pheochromocytoma. Since then a number of investigators2, 3, 4, 5 have confirmed their experience and expanded their conclusions, so that today the presence of large excesses of epinephrine and/or norepinephrine in the urine is generally regarded as pathognomonic of this disease.Therefore, when a case presents the findings of so-called diagnostic levels of the catechol amines in the urine, and no tumor can be found, it merits interest and consideration. Such...Bibliography1. Engelvon Euler AUS: Diagnostic value of increased urinary output of noradrenaline and adrenaline in pheochromocytoma, Lancet 2: 387, 1950. CrossrefMedlineGoogle Scholar2. GoldenbergRapport MMM: Nor-epinephrine and epinephrine in human urine (Addison's disease, essential hypertension, pheochromocytoma), J. Clin. Investigation 30: 641, 1951. Google Scholar3. Lund A: Adrenaline and noradrenaline in blood and urine in cases of pheochromocytoma, Scandinav. J. Clin. and Lab. Invest. 4: 263, 1952. CrossrefMedlineGoogle Scholar4. GoldenbergSerlinEdwardsRapport MITMM: Chemical screening methods for the diagnosis of pheochromocytoma, Am. J. Med. 16: 310 (Mar.) 1954. CrossrefMedlineGoogle Scholar5. Weil-Malherbe H: Pheochromocytoma, catechols in urine and tumor tissue, Lancet 2: 282 (Aug. 11) 1956. Google Scholar6. RothKvale GMWF: Pheochromocytoma, factors in the accurate pharmacologic diagnosis, Dis. of Chest 29: 366 (Apr.) 1956. CrossrefMedlineGoogle Scholar7. Finnerty FA: Does vascular damage follow toxemia of pregnancy? Internist's appraisal of 303 toxemia patients in a toxemia clinic, J. A. M. A. 154: 1075 (Mar. 27) 1954. CrossrefMedlineGoogle Scholar8. Seligson D: Personal communication. Google Scholar9. von EulerLuft USR: Noradrenaline output in urine after infusion in man, Brit. J. Pharmacol. 6: 286 (June) 1951. Google Scholar10. MangerWakingBollman WMKGJL: Effect of increased intracranial pressure on pressor amine concentration in blood, Federation Proc. 14: 98 (Mar.) 1955. Google Scholar11. Rosenberg LM: Pheochromocytoma of the urinary bladder. Report of a case, New England J. Med. 257: 1212, 1957. CrossrefMedlineGoogle Scholar12. von EulerFolkow USB: Einfluss verschiedener afferenter Nervenreize auf die Zusammensetzung der Nebennierenmarkinkrites bei der Katze, Arch. f. exper. Path. u. Pharmakol. 219: 242, 1953. Google Scholar13. WadaSeoAbe MMK: Further studies of influence of cold on rate of epinephrine secretion from suprarenal glands with simultaneous determination of blood sugar, Tohoku J. Exper. Med. 26: 381 (June 30) 1935. CrossrefGoogle Scholar14. ForsmannHanssonJensen OGCC: Adrenal function in coronary thrombosis, Acta med. Scandinav. 142: 441, 1952. CrossrefMedlineGoogle Scholar15. FunkensteinGreenblattSolomon DHMHC: Norepinephrine-like and epinephrine-like substances in psychotic and psychoneurotic patients, Am. J. Psychiat. 108: 652 (Mar.) 1952. CrossrefMedlineGoogle Scholar16. von EulerLundberg USU: Effect of flying on epinephrine excretion in Air Force personnel, J. Appl. Physiol. 6: 551 (Mar.) 1954. CrossrefMedlineGoogle Scholar17. Weil-Malherbe H: Effect of convulsive therapy on plasma adrenalin and noradrenalin, J. Ment. Sc. 101: 156 (Jan.) 1955. CrossrefGoogle Scholar18. GoldfeinZileliGoodman AMSD: The measurement of epinephrine and norepinephrine in human plasma, J. Clin. Endocrinol. and Metabolism 16: 949, 1956. Google Scholar19. GoodmanGilman LSA: The pharmacological basis of therapeutics, 2nd Ed., 1955, The Macmillan Company, New York. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Portland, Oregon*Received for publication June 3, 1958.From the Holladay Park Hospital, Portland, Oregon.Presented at the 1958 Northwest Regional Conference of The American College of Physicians.†Deceased, May 4, 1959. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byBibliographyObservations on Patients with PhaeochromocytomaA possible source of error in the diagnosis of phaeochromocytoma 1 September 1959Volume 51, Issue 3Page: 613-617KeywordsEpinephrineExcretionHemorrhageNorepinephrinePheochromocytomaRetinaUrine ePublished: 1 December 2008 Issue Published: 1 September 1959 PDF downloadLoading ...