PHOSPHATASE CONTENT OF HUMAN SERUM IN PULMONARY TUBERCULOSIS FOLLOWING THE ADMINISTRATION OF VITAMIN D
Authors: Paul D. Crimm, J. W. Strayer
Journal: Annals of Internal Medicine (1936)

Article1 April 1936PHOSPHATASE CONTENT OF HUMAN SERUM IN PULMONARY TUBERCULOSIS FOLLOWING THE ADMINISTRATION OF VITAMIN DPAUL D. CRIMM, A.B., M.D., F.A.C.S., J. W. STRAYER, A.B., M.D.PAUL D. CRIMM, A.B., M.D., F.A.C.S., J. W. STRAYER, A.B., M.D.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-9-10-1393 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptPhosphatase is an organic catalyst capable of either synthesizing or hydrolyzing any mono-ester of phosphoric acid. It was first discovered in rice and wheat bran by Suzuki, Yoshimura and Takaishi1in 1907. (For a full review of the literature see Kay.2) It is present in large quantities in the intestinal mucosa, kidney and bone. Smaller quantities are found in practically all other organs and secretions. Fetal bone and the bone of young animals are richest in the enzyme, but the content diminishes as maturity is reached. The optimum pH in vitro is around 9—it is activated by Mg (Erdtman3) and...Bibliography1. SUZUKIYOSHIMURATAKAISHI UKM: Über ein Enzym "Phytase" das "Anhydro-oxy-methylen-diphosphorsaure" spaltet, Bull. Coll. of Agric., Tokyo, 1907, vii, 503. Google Scholar2. KAY HD: Phosphatase in growth and disease of bone, Physiol. Rev., 1932, xii, 384-422. CrossrefGoogle Scholar3. ERDTMAN H: Glycerophosphatspaltung durch Nierenphosphatase und ihre Aktivierung, Ztschr. f. Physiol. Chem., 1927, clxxii, 182-198. CrossrefGoogle Scholar4. BAKWINBODANSKY HO: Factors influencing measurement of the phosphatase activity of tissue extract, Jr. Biol. Chem., 1933, ci, 641-656. CrossrefGoogle Scholar5. ROBISONSOAMES RKM: The possible significance of hexosephosphoric esters in ossification. VIII. Calcification in vitro, Biochem. Jr., 1930, xxiv, 1922-1926. CrossrefGoogle Scholar6. CRIMMSTRAYER PDJW: Phosphatase content of blood serum and tissues in the rat following administration of vitamins D and A, Jr. Biol. Chem., 1936, cxii, 511-515. CrossrefGoogle Scholar7. TAYLORWELDBRANIONKAY NBCBHDHD: A study of the action of irradiated ergosterol and of its relationship to parathyroid function, Part I, Canad. Med. Assoc. Jr., 1931, xxiv, 763-777. Google Scholar8. TAYLORWELDBRANIONKAY NCCBHDHD: A study of the action of irradiated ergosterol and of its relationship to parathyroid function, Part II, Canad. Med. Assoc. Jr., 1931, xxv, 20-35. Google Scholar9. BODANSKY A: Phosphatase studies. II. Determination of serum phosphatase. Factors influencing the accuracy of the determination, Jr. Biol. Chem., 1933, ci, 93-104. CrossrefGoogle Scholar10. BODANSKY A: Phosphatase studies. I. Determination of inorganic phosphate. Beer's law and interfering substances in the Kuttner, Lichtenstein method, Jr. Biol. Chem., 1932, xcix, 197-206. CrossrefGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Evansville, Indiana*Received for publication November 13, 1935.From the Research Laboratory, Boehne Tuberculosis Hospital. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 April 1936Volume 9, Issue 10Page: 1393-1397KeywordsBoneEnzymesKidneysMucous membranesPhosphatasesResearch laboratoriesVitamin D Issue Published: 1 April 1936 PDF downloadLoading ...