ENCEPHALOPATHY, NEPHROSIS, AND RENAL GRANULOMA FOLLOWING SULFONAMIDE THERAPY; CASE WITH AUTOPSY
Authors: Bernard Maisel, Charles S. Kubik, James B. Ayer
Journal: Annals of Internal Medicine (1944)

Case Reports1 February 1944ENCEPHALOPATHY, NEPHROSIS, AND RENAL GRANULOMA FOLLOWING SULFONAMIDE THERAPY; CASE WITH AUTOPSYBERNARD MAISEL, CHARLES S. KUBIK, JAMES B. AYERBERNARD MAISELSearch for more papers by this author, CHARLES S. KUBIKSearch for more papers by this author, JAMES B. AYERSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-20-2-311 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptINTRODUCTIONCurrent medical literature contains many papers dealing directly or indirectly with the toxic effects of the sulfonamides. As death is not the usual outcome of such cases, autopsies are not numerous and, therefore, the pathological manifestations are as yet not fully recognized.Clinical evidence indicates that the kidneys may be affected by these drugs, and in those patients who succumb, marked changes in the kidneys have been demonstrated. In these cases the pathological physiology is uncertain and has usually been attributed to renal obstruction consequent to the precipitation of the less soluble forms of the sulfonamides. The case reported...Bibliography1. LITTLE SC: Nervous and mental effects of sulfonamides, Jr. Am. Med. Assoc., 1942, cxix, 467-474. CrossrefGoogle Scholar2. ROSEMANARING ECD: Encephalopathy associated with sulfamethylthiazole therapy, New England Jr. Med., 1941, ccxxiv, 416-420. CrossrefGoogle Scholar3. FISHERGILMOUR JHJR: Encephalomyelitis following administration of sulphanilamide with note on histological findings, Lancet, 1939, ii, 301. CrossrefGoogle Scholar4. Cabot Case Records of the Massachusetts General Hospital (Case 28501), New England Jr. Med., 1942, ccxxvii, 922-927. Google Scholar5. CLIMENKOWRIGHT DRAW: Effects of continued administration of sulfathiazole and sulfapyridine in monkeys, Arch. Path., 1941, xxxii, 794-817. Google Scholar6. MAISELMCSWAINGLENN BBF: Lesions produced with sulfadiazine, Proc. Soc. Exper. Biol. and Med., 1942, xlix, 715-717. CrossrefGoogle Scholar7. MAISELMCSWAINGLENN BBF: Effects of administration of sodium sulfadiazine to dogs, Arch. Surg., 1943, xlvi, 326-335. CrossrefGoogle Scholar8. LUETSCHERBLACKMAN JJS: Severe injury to kidneys and brain following sulfathiazole administration: High serum sodium and chloride levels and persistent cerebral damage, ANN. INT. MED., 1943, xviii, 741-756. Google Scholar9. SCHONHOLZER G: Die Bindung von Prontosil an die Bluteiweisskörper, Klin. Wchnschr., 1940, xix, 790-791. CrossrefGoogle Scholar10. DAVIS BD: Binding of sulfonamides by plasma proteins, Science, 1942, xcv, 78. CrossrefGoogle Scholar11. RICH AR: Rôle of hypersensitivity in periarteritis nodosa as indicated by 7 cases developing during serum sickness and sulfonamide therapy, Bull. Johns Hopkins Hosp., 1942, lxxi, 123. Google Scholar12. RICH AR: Additional evidence of the rôle of hypersensitivity in the etiology of periarteritis nodosum. Another case associated with a sulfonamide reaction, Ibid., 1942, lxxi, 375-379. Google Scholar13. MALLORYBRICKLEY TBWJ: Symposium on the management of the Cocoanut Grove burns at the Massachusetts General Hospital, Ann. Surg., 1943, cxvii, 865-884. CrossrefGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: *Received for publication June 14, 1943.From The Departments of Pathology and Neurology of the Massachusetts General Hospital, Boston, Mass. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byAcute Granulomatous Interstitial Nephritis Secondary to Bisphosphonate Alendronate SodiumAcute Renal Insufficiency Due to Lower-Nephron NephrosisKidney Complications during Sulphonamide Therapy1Renal Complications of Sulfonamide Therapy 1 February 1944Volume 20, Issue 2Page: 311-326KeywordsAutopsyBrain diseasesDrugsGranulomasKidneysNeurologyRenal physiologySulfonamide ePublished: 1 December 2008 Issue Published: 1 February 1944 PDF downloadLoading ...