HOMOZYGOUS HEMOGLOBIN C DISEASE: REPORT OF THREE CASES
Authors: K R TANAKA, G O CLIFFORD
Journal: Annals of Internal Medicine (1958)

Article1 July 1958HOMOZYGOUS HEMOGLOBIN C DISEASE: REPORT OF THREE CASESKOUICHI R. TANAKA, M.D., GEORGE O. CLIFFORD, M.D.KOUICHI R. TANAKA, M.D.Search for more papers by this author, GEORGE O. CLIFFORD, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-49-1-30 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptAlthough hemoglobin electrophoresis is being performed in numerous centers throughout the world, patients with homozygous hemoglobin C disease are encountered infrequently.1Hemoglobin C trait has been found to be present in 2 to 3% of American Negroes,2, 3and the incidence of homozygous hemoglobin C disease has been calculated to be one in 6,000 Negroes.1In the course of a study of hemoglobinopathies during the period of 1953 to 1956, three patients with this hemoglobin pattern have been encountered. Each of these patients was a diagnostic problem until hemoglobin electrophoresis was performed, which revealed only the presence of hemoglobin C....Bibliography1. TerryMotulskyRath DWAGCE: Homozygous hemoglobin C: a new hereditary hemolytic disease, New England J. Med. 251: 365, 1954. CrossrefMedlineGoogle Scholar2. Schneider RG: Incidence of hemoglobin C trait in 505 normal Negroes: a family with homozygous hemoglobin C and sickle-cell trait union, J. Lab. and Clin. Med. 44: 133, 1954. MedlineGoogle Scholar3. SmithConley EWCL: Filter paper electrophoresis of human hemoglobins with special reference to the incidence and clinical significance of hemoglobin C, Bull. Johns Hopkins Hosp. 93: 94, 1953. MedlineGoogle Scholar4. SchwartzHartz SOWH: Mediterranean anemia in the Negro. A reevaluation of four patients and their families, Blood 10: 1256, 1955. CrossrefMedlineGoogle Scholar5. SmithConley EWCL: Clinical features of the genetic variants of sickle cell disease, Bull. 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KaplanZuelzerNeel EWWJV: A new inherited abnormality of human hemoglobin and its interaction with sickle cell hemoglobin, Blood 6: 1240, 1951. CrossrefMedlineGoogle Scholar25. WeinsteinSpurlingKleinNecheles IMCLHTF: Radioactive sodium chromate for the study of survival of red blood cells. III. The abnormal hemoglobin syndromes, Blood 9: 1155, 1954. CrossrefMedlineGoogle Scholar26. LangeHagen RDPS: Hemoglobin C disease in identical twins, Am. J. M. Sc. 229: 655, 1955. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Detroit, Michigan*Received for publication May 29, 1957.From the Hematology Service, Department of Medicine, Wayne State University College of Medicine, and the City of Detroit Receiving Hospital, Detroit, Michigan.Requests for reprints should be addressed to Kouichi R. Tanaka, M.D., Department of Medicine, University of California Medical Center, Los Angeles 24, California. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byThe influence of hemoglobinopathies on reproductionIneffective erythropoiesis 1 July 1958Volume 49, Issue 1Page: 30-42KeywordsBloodBlood plasmaExcretionGeneticsHematology and oncologyHemoglobinHemoglobinopathiesHemolytic anemiaHospital medicineThalassemia ePublished: 1 December 2008 Issue Published: 1 July 1958 PDF downloadLoading ...