tbuckley/cabot-search huggingface dataset:
Interventricular septal curvature obtained by echocardiography can predict severity of chronic thromboembolic pulmonary hypertension
Authors: Akane Matsumura, Hajime Kasai, Toshihiko Sugiura, Ayako Shigeta, Ryougo Ema, Yoriko Sakurai, Yukiko Matsuura, Misuzu Yahaba, Naoko Kawata, Seiichiro Sakao, Yasunori Kasahara, Nobuhiro Tanabe, Koichiro Tatsumi
Journal: European Respiratory Journal (2014)

Purpose: This study was conducted to determine whether the curvature of the interventricular septum (IVS) by echocardiography was influenced by severity of chronic thromboembolic pulmonary hypertension (CTEPH).  Materials and Methods: Subjects (n=45,60±11 [mean ± SD] years, 13 male ) with proven CTEPH, which including patients treated with pulmonary endarterectomy or/and pulmonary vasodilators, underwent echocardiography within two days before right heart catheterization (RHC). Using the cross-sectional echocardiography, we put three points on the endocardial surface of the IVS (anterior, inferior and the center of both sides) at the mid-papillary level and calculated the radius of circle throughout three points.  IVS curvature was defined to be the reciprocal of radius at end-systolic phase, which was compared with pulmonary hemodynamics by RHC.  Results: Systolic pulmonary artery pressure (sPAP), mean pulmonary artery pressure (mPAP) and pulmonary vascular resistance (PVR) from RHC were 55±25 mmHg, 30±12 mmHg and 5.3±3.3 WU, respectively. The correlation coefficients of IVS curvature with sPAP, mPAP and PVR were -0.67 ( P   P   P    Conclusions: IVS curvature based on echocardiography can be used to estimate pulmonary hemodynamics in subjects with CTEPH.  This imaging modality may be helpful to assess hemodynamics in CTEPH, simply and non-invasively.
Tumor-Specific Immunity in 3-Methylcholanthrene-Induced Murine Fibrosarcomas. I. In Vivo Demonstration of Immunity With Three Preparations of Soluble Antigens 2
Authors: George E. Brannen, Jody S. Adams, George W. Santos
Journal: JNCI Journal of the National Cancer Institute (1974)

The in vivo response to soluble, syngeneic, tumor-specific antigens (TSA) from 3-methylcholanthreneinduced fibrosarcomas was measured by the 3-, 24-, and 48-hour foot pad swelling (FPS) response in mice. Mice immunized to tumor by surgical removal of a growing tumor had specific resistance to challenge with that tumor and specific 3-hour (Arthus) and 24- and 48-hour (delayedhypersensitivity) foot pad responses to preparations containing viable, lyophilized (3M KCI extracts), homogenized, and frozen-thawed extracts, and sonication extracts of tumor cells. Specific FPS was seen in immunized mice with 3M KCI tumor extracts at protein concentrations of 200-10,000 µg/ml. Protein concentrations of 5000 µg/ml appeared to be optimal for testing. Mice given tumor cells had specific 3-hour FPS to KCI-prepared TSA at 7 days after tumor transfer. All responses were negative at 28 days, when tumor diameters were >1.5 cm. Surgical removal of tumor in such mice restored 3−, 24−, and 48hour specific FPSwithin 24 hour
A case-controlled study on the use of HBsAg-positive donors for allogeneic hematopoietic cell transplantation
Authors: George K. K. Lau, Albert K. W. Lie, Yok Lam Kwong, Cheuk Kwong Lee, Jinlin Hou, Yu Lung Lau, Wei Ling Lim, Raymond Liang
Journal: Blood (2000)
Comparison of gender-related risk factors for COPD - Results from the Canadian obstructive lung disease (CanCOLD) study
Authors: Wan Tan, Denis O'Donnell, Shawn Aaron, Darcy Marciniuk, J. Mark Fitzgerald, Robert Cowie, Kenneth Chapman, Paul Hernandez, Don Sin, Francois Maltais, Jean Bourbeau
Journal: European Respiratory Journal (2013)

Background: COPD is an important disease in women, with an increasing prevalence in developed and developing countries.

Objectives: To compare risk factors for COPD by gender in the general population.

Methods: The random sample consisted of 5176 people aged 40 years and older from 9 sites in Canada who completed interviewer administered questionnaires on respiratory symptoms and diseases, co-morbidities and health related quality of life and who performed spirometry before and after administration of 200ug of inhaled salbutamol/albuterol. The analysis was performed for 4893 [95%] subjects who had ATS acceptable and repeatable spirometric data. Logistic regression analysis was used to compute adjusted odds ratio [OR, 95%CI] for independent risk factors for men and women.

Results: Common independent risk factors for men and women included increasing age, smoking, prior diagnosis of asthma, presence of chronic cough and phlegm, a history of childhood hospitalization for severe respiratory illness and exposure to passive smoking. The overall risk for COPD for women referenced to men in the study population, with adjustment for all risk factors and for pack years of cigarettes smoked, is shown below, by age groups.

![Figure][1] 



Conclusions: Men and women have common risk factors for mild to moderate COPD. Women compared with men, did not appear to be at increased risk in the general population.

 [1]: pending:yes
Serological investigation of the prevalence of anti-dengue IgM and IgG antibodies in Attapeu Province, South Laos
Authors: G. Peyerl-Hoffmann, B. Schwöbel, S. Jordan, V. Vamisaveth, R. Phetsouvanh, E.M. Christophel, S. Phompida, F.V. Sonnenburg, T. Jelinek
Journal: Clinical Microbiology and Infection (2004)
Multiple miliary osteoma cutis is a distinct disease entity: four case reports and review of the literature
Authors: R.M. Myllylä, K.M. Haapasaari, R. Palatsi, E.L. Germain-Lee, P.M. Hägg, J. Ignatius, J. Tuukkanen
Journal: British Journal of Dermatology (2010)

Multiple miliary osteoma cutis (MMOC) is a rare nodular skin disease characterized by tiny bone nodules which usually form on the facial skin, typically in middle age. The aetiology of this phenomenon is poorly understood.To search for possible bone formation progenitors and to look for a possible association with mutations in the GNAS gene (encoding the G-protein α-stimulatory subunit) and related hormonal parameters in patients with MMOC. We also reviewed the literature and discuss the aetiology and pathogenesis of adult-onset primary osteomas.We report four cases of MMOC. Histological samples were analysed for bone morphogenetic protein (BMP)-2, BMP-4 and oestrogen receptor-α known to be involved in bone formation. Endocrinological laboratory investigations and hand X-rays were performed to exclude a systemic disease. The GNAS gene was sequenced from DNA extracted from peripheral blood in all four patients and from a skin sample in one patient to exclude somatic mutations.Histological analyses revealed intramembranous cutaneous bone formation resembling the findings seen in GNAS gene-based osteoma cutis disorders. However, we did not find any germline or somatic GNAS gene mutations in our patients and all laboratory investigations gave normal results. BMP-2 and -4 were expressed normally in MMOC samples, but oestrogen receptor-α was not expressed. Altogether 47 MMOC cases, 41 female and six male, have been published between 1928 and 2009. Of these cases, 55% had a history of pre-existing acne and only 15% had extrafacial osteomas.MMOC is a rare but distinct disease entity of unknown aetiology. Histologically, the tiny nodular osteomas show intramembranous superficial ossification but the aetiology appears to be different from GNAS-related disorders. The osteomas seem to increase slowly in number after appearing in middle age.
Long-Term Cultivation of Hypodiploid Human Tumor Cells&lt;xref ref-type="fn" rid="FN2"&gt;2&lt;/xref&gt;&lt;xref ref-type="fn" rid="FN3"&gt;3&lt;/xref&gt;
Authors: Nelly Auersperg
Journal: JNCI Journal of the National Cancer Institute (1964)

Journal Article Long-Term Cultivation of Hypodiploid Human Tumor Cells Get access Nelly Auersperg Nelly Auersperg Cytology Laboratory, British Columbia Cancer Institute, Vancouver, British Columbia, Canada Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 32, Issue 1, January 1964, Pages 135–163, https://doi.org/10.1093/jnci/32.1.135 Published: 01 January 1964 Article history Received: 01 July 1963 Published: 01 January 1964
Dissociation of glomerular filtration rate from tubulointerstitial fibrosis in experimental chronic cyclosporine nephropathy
Authors: L W Elzinga, S Rosen, W M Bennett
Journal: Journal of the American Society of Nephrology (1993)

In addition to its well-recognized ability to provoke acute renal dysfunction by promoting intense renal vasoconstriction, cyclosporine produces a chronic tubulointerstitial nephropathy characterized by striped interstitial fibrosis in humans. With a model of chronic cyclosporine nephropathy in which striped fibrosis develops in the uninephrectomized salt-depleted rat, the relationship between renal functional impairment and structural changes was studied during cyclosporine treatment and after its withdrawal in order to ascertain the natural history of this lesion. Groups of uninephrectomized rats maintained on a salt-depleted (-NaCl) or salt-replete (+NaCl) diet were treated with cyclosporine, 15 mg/kg per day, or vehicle by sc injection. GFR and morphology were assessed at 14 and 28 days of treatment and at intervals up to 28 days after drug withdrawal. Although GFR was similarly depressed in cyclosporine-treated animals on either diet (P < 0.001 versus vehicle), tubulointerstitial injury was largely confined to cyclosporine-treated rats on the -NaCl diet (P < 0.001 versus cyclosporine/+NaCl and vehicle). At 28 days after the withdrawal of cyclosporine, there was a marked discordance between renal structure and function in the cyclosporine/-NaCl group as GFR returned toward normal (P > 0.05 versus cyclosporine/+NaCl) but prominent tubulointerstitial injury persisted and, in some instances, even progressed (P < 0.001 versus cyclosporine/+NaCl and vehicle). Thus, sodium intake emerges as an important determinant of structural tubulointerstitial changes, whereas reductions in GFR during cyclosporine therapy are equivalent in sodium-depleted or sodium-replete animals.
Neurocutaneous melanosis and congenital melanocytic naevi: a retrospective review of clinical and radiological characteristics
Authors: C. Sibbald, H. Randhawa, H. Branson, E. Pope
Journal: British Journal of Dermatology (2015)

Journal Article Neurocutaneous melanosis and congenital melanocytic naevi: a retrospective review of clinical and radiological characteristics Get access C. Sibbald, C. Sibbald University of Toronto 27 King's College Circle Toronto ON M5S 1A1 Canada Search for other works by this author on: Oxford Academic Google Scholar H. Randhawa, H. Randhawa Division of Dermatology The Hospital for Sick Children 555 University Avenue Toronto ON M5G 1X8 Canada Search for other works by this author on: Oxford Academic Google Scholar H. Branson, H. Branson Department of Medical Imaging Division of Neuroradiology The Hospital for Sick Children 555 University Avenue Toronto ON M5G 1X8 Canada Search for other works by this author on: Oxford Academic Google Scholar E. Pope E. Pope Division of Dermatology The Hospital for Sick Children 555 University Avenue Toronto ON M5G 1X8 Canada Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 173, Issue 6, 1 December 2015, Pages 1522–1524, https://doi.org/10.1111/bjd.13949 Published: 01 December 2015
Biodegradable Antimicrobial Polycarbonates with In Vivo Efficacy against Multidrug‐Resistant MRSA Systemic Infection
Authors: Junchi Cheng, Willy Chin, Huihui Dong, Liang Xu, Guansheng Zhong, Yuan Huang, Lanjuan Li, Kaijin Xu, Min Wu, James L. Hedrick, Yi Yan Yang, Weimin Fan
Journal: Advanced Healthcare Materials (2015)

The threat of multidrug resistance requires development of new medicines to treat methicillin-resistant Staphylococcus aureus (MRSA) infection. The biodegradable polycarbonates that have broad-spectrum antibacterial activity and show the highest selectivity toward S. aureus are studied for their antibacterial properties against clinically isolated MRSA and toxicity both in vitro and in vivo. Minimum inhibitory concentrations of the polymers are demonstrated to be much lower than those of cefoxitin (a commonly used antibiotic) against all 31 isolates but slightly higher than those of vancomycin, a last resort medication for treating severe Gram-positive drug-resistant bacterial infections. Both polymers show low hemolytic activity toward human red blood cells, making them highly selective toward MRSA in vitro. A time-kill study reveals that these polymers have high bactericidal efficiency and eradicate MRSA more rapidly than vancomycin. Results from a resistance development study also attests to the polymers low tendency toward resistance. Furthermore, the in vivo study shows that one of the polymers is highly efficacious in a mouse systemic infection model, and reduced MRSA counts in the blood more promptly than vancomycin. The administration of the polymer to mice further indicates that it did not cause any dysfunctions of liver and kidney as well as blood electrolytes. This is the first example of a polymeric therapeutics for treating systemic MRSA infection. Taken together, the biodegradable antimicrobial polycarbonate may be a better candidate for treating MRSA infection.
Antitumour effects in mycosis fungoides of the immunomodulatory, tellurium-based compound, AS101
Authors: G.M. Frei, M. Kremer, K.-M. Hanschmann, S. Krause, M. Albeck, B. Sredni, B.S. Schnierle
Journal: British Journal of Dermatology (2008)

The immunomodulator AS101 [ammonium trichloro (dioxoethylene-O,O') tellurate], a nontoxic tellurium (IV) compound, has antitumoral effects which were demonstrated in several preclinical and clinical studies.To investigate the antitumour activity of AS101 on cutaneous T-cell lymphoma (CTCL), of which mycosis fungoides (MF) is the most frequent disease variant.We used a newly established mouse xenograft model for MF to test the effect of AS101 in vivo and analysed apoptosis induction in vitro.When injected intratumorally, AS101 delayed tumour growth in a dose-dependent manner. In vitro, AS101 induced a dose-dependent G2/M arrest in the CTCL cell lines Hut78 and MyLa. Moreover, higher concentrations of AS101 induced apoptosis in MyLa cells. Programmed cell death was associated with the loss of mitochondrial transmembrane potential and activation of caspase 9 and caspase 3. AS101 also elevated intracellular reactive oxygen species (ROS) production; the antioxidant, Mn superoxide dismutase, significantly reduced the degree of apoptosis, suggesting that ROS play a key role in apoptosis induction.These findings indicate that AS101 may be a promising antitumour drug for CTCL.
Differences in the effects of divorce on major depression in men and women
Authors: M L Bruce, K M Kim
Journal: American Journal of Psychiatry (1992)

The authors examined the relationship between marital disruption and major depressive episodes.The analyses were based on longitudinal, community-based data from the New Haven Epidemiologic Catchment Area (ECA) program on respondents 18-60 years old. The presence and history of major depression was assessed by using the National Institute of Mental Health Diagnostic Interview Schedule.Martial disruption was associated with higher prevalence rates of major depression in both men and women, but only men had a greater risk of a first-onset major depression. Differences between men and women in rates of major depression were observed only among married subjects.These findings suggest that the relationship between marital disruption and major depressive episode differs for men and women. They also provide further evidence that differences between men and women in rates of depression vary by marital status.
Risk factors for abscess formation in patients with superficial cellulitis (erysipelas) of the leg
Authors: D. Picard, A. Klein, S. Grigioni, P. Joly
Journal: British Journal of Dermatology (2012)

Superficial cellulitis of the leg (erysipelas) is a frequent skin infection. Abscess formation is the most frequent local complication. Determinants of abscess formation in patients with leg cellulitis have not yet been clearly established.To assess the risk factors for abscess formation in patients with leg cellulitis.The clinical, biological and bacteriological records of all patients referred to the dermatology department of a university hospital for superficial cellulitis of the leg during a 3-year period were retrospectively reviewed. Using univariate and multivariate analysis, patients' main characteristics at baseline were compared between the group of patients who developed abscess and the group who did not.A total of 164 patients (93 female, 71 male), mean age 65±18 years, were included. Abscess occurred in 13 cases (8%). The following general factors were positively associated with abscess formation: male sex, smoking, alcohol abuse and delayed introduction of antibiotic treatment. Based on multivariate analysis, only chronic alcohol abuse [odds ratio (OR) 4·3, 95% confidence interval (CI)1·08-20·57] and delayed antibiotic treatment initiation (OR 1·4, 95% CI 1·02-2·04) remained independently associated with abscess formation.Alcohol abuse and delayed initiation of antibiotic treatment are risk factors for abscess formation in patients with cellulitis of the leg. Patients with these predictors must be monitored carefully for abscess formation.
Real-time <i>In Vivo</i> Tissue Characterization with Diffuse Reflectance Spectroscopy during Transthoracic Lung Biopsy: A Clinical Feasibility Study
Authors: Jarich W. Spliethoff, Warner Prevoo, Mark A.J. Meier, Jeroen de Jong, Houke M. Klomp, Daniel J. Evers, Hendricus J.C.M. Sterenborg, Gerald W. Lucassen, Benno H.W. Hendriks, Theodoor J.M. Ruers
Journal: Clinical Cancer Research (2015)

This study presents the first in vivo real-time tissue characterization during image-guided percutaneous lung biopsies using diffuse reflectance spectroscopy (DRS) sensing at the tip of a biopsy needle with integrated optical fibers.Tissues from 21 consented patients undergoing lung cancer surgery were measured intraoperatively using the fiber-optic platform capable of assessing various physical tissue properties highly correlated to tissue architecture and composition. In addition, the method was tested for clinical use by performing DRS tissue sensing during 11 routine biopsy procedures in patients with suspected lung cancer.We found that water content and scattering amplitude are the primary discriminators for the transition from healthy lung tissue to tumor tissue and that the reliability of these parameters is not affected by the amount of blood at the needle tip. In the 21 patients measured intraoperatively, the water-to-scattering ratio yielded a 56% to 81% contrast difference between tumor and surrounding tissue. Analysis of the 11 image-guided lung biopsy procedures showed that the tissue diagnosis derived from DRS was diagnostically discriminant in each clinical case.DRS tissue sensing integrated into a biopsy needle may be a powerful new tool for biopsy guidance that can be readily used in routine diagnostic lung biopsy procedures. This approach may not only help to increase the successful biopsy yield for histopathologic analysis, but may also allow specific sampling of vital tumor tissue for genetic profiling.
Heterogeneity of Virus Production and Antigenicity Detected in Cell Clones Derived From a “Nonproducer” Neoplasm Induced by Moloney Murine Sarcoma Virus
Authors: Lloyd W. Law, Kenneth S. S. Chang, Kiyoi Nakata
Journal: JNCI Journal of the National Cancer Institute (1974)

Journal Article Heterogeneity of Virus Production and Antigenicity Detected in Cell Clones Derived From a “Nonproducer” Neoplasm Induced by Moloney Murine Sarcoma Virus Get access Lloyd W. Law, Lloyd W. Law Search for other works by this author on: Oxford Academic PubMed Google Scholar Kenneth S. S. Chang, Kenneth S. S. Chang Search for other works by this author on: Oxford Academic PubMed Google Scholar Kiyoi Nakata Kiyoi Nakata Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 52, Issue 2, February 1974, Pages 437–443, https://doi.org/10.1093/jnci/52.2.437 Published: 01 February 1974 Article history Received: 22 June 1973 Accepted: 14 September 1973 Published: 01 February 1974
Requisite Role of Kv1.5 Channels in Coronary Metabolic Dilation
Authors: Vahagn Ohanyan, Liya Yin, Raffi Bardakjian, Christopher Kolz, Molly Enrick, Tatevik Hakobyan, John Kmetz, Ian Bratz, Jordan Luli, Masaki Nagane, Nadeem Khan, Huagang Hou, Periannan Kuppusamy, Jacqueline Graham, Frances Kwan Fu, Danielle Janota, Moses O. Oyewumi, Suzanna Logan, Jonathan R. Lindner, William M. Chilian
Journal: Circulation Research (2015)

Rationale: In the working heart, coronary blood flow is linked to the production of metabolites, which modulate tone of smooth muscle in a redox-dependent manner. Voltage-gated potassium channels (Kv), which play a role in controlling membrane potential in vascular smooth muscle, have certain members that are redox-sensitive. Objective: To determine the role of redox-sensitive Kv1.5 channels in coronary metabolic flow regulation. Methods and Results: In mice (wild-type [WT], Kv1.5 null [Kv1.5 −/− ], and Kv1.5 −/− and WT with inducible, smooth muscle–specific expression of Kv1.5 channels), we measured mean arterial pressure, myocardial blood flow, myocardial tissue oxygen tension, and ejection fraction before and after inducing cardiac stress with norepinephrine. Cardiac work was estimated as the product of mean arterial pressure and heart rate. Isolated arteries were studied to establish whether genetic alterations modified vascular reactivity. Despite higher levels of cardiac work in the Kv1.5 −/− mice (versus WT mice at baseline and all doses of norepinephrine), myocardial blood flow was lower in Kv1.5 −/− mice than in WT mice. At high levels of cardiac work, tissue oxygen tension dropped significantly along with ejection fraction. Expression of Kv1.5 channels in smooth muscle in the null background rescued this phenotype of impaired metabolic dilation. In isolated vessels from Kv1.5 −/− mice, relaxation to H 2 O 2 was impaired, but responses to adenosine and acetylcholine were normal compared with those from WT mice. Conclusions: Kv1.5 channels in vascular smooth muscle play a critical role in coupling myocardial blood flow to cardiac metabolism. Absence of these channels disassociates metabolism from flow, resulting in cardiac pump dysfunction and tissue hypoxia.
Factors impacting on length of stay and mortality of community-acquired pneumonia
Authors: J. Garau, F. Baquero, E. Pérez-Trallero, J.-L. Pérez, A.M. Martín-Sánchez, C. García-Rey, J.E. Martín-Herrero, R. Dal-Ré
Journal: Clinical Microbiology and Infection (2008)
Kinetic Evaluation of the Effect of Hydroxyurea on Viability of Replicating Cultured Leukemia L1210 Cells&lt;xref ref-type="fn" rid="FN2"&gt;2&lt;/xref&gt;
Authors: L. J. Wilkoff, H. H. Lloyd, E. A. Dulmadge, G. J. Dixon
Journal: JNCI Journal of the National Cancer Institute (1970)

Replicating cultured leukemia L1210 cells exposed to cytotoxic concentrations of hydroxyurea were killed at a first-order rate, but the rate of population reduction was relatively independent of hydroxyurea concentration. In a comparative study, proliferating L1210 cells exposed to cytotoxic concentrations of 5-iodo-2′-deoxyuridine were killed at a rate deviating from first-order kinetics; however, the kinetic parameters were also independent of concentration. A comparison of the sensitivity of proliferating HEp-2 and L1210 cell populations to hydroxyurea (1000 μg/ml) demonstrated that L1210 cells were significantly more sensitive to this agent than HEp-2 cells. The results of the study suggest that the potential therapeutic advantage gained by increased hydroxyurea concentration is limited and that treatment regimens which take into account the cell cycle parameters of the particular cell population being treated may enhance the effectiveness of the agent.