THE DEVELOPMENT OF GASTRIC CARCINOMA IN PERNICIOUS ANEMIA
Authors: J W NORCROSS, S E MONROE, B G GRIFFIN
Journal: Annals of Internal Medicine (1952)

Article1 August 1952THE DEVELOPMENT OF GASTRIC CARCINOMA IN PERNICIOUS ANEMIAJOHN W. NORCROSS, M.D., F.A.C.P., STANLEY E. MONROE, M.D., BELTON G. GRIFFIN, M.D.JOHN W. NORCROSS, M.D., F.A.C.P.Search for more papers by this author, STANLEY E. MONROE, M.D.Search for more papers by this author, BELTON G. GRIFFIN, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-37-2-338 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptIn 1876 Quincke1first reported the occurrence of a carcinoma of the stomach in a patient suffering from pernicious anemia. It was not until the third decade of this century, however, that investigators began statistical studies of the incidence of gastric malignancy and premalignant lesions in large series of pernicious anemia cases. More recently, Rigler, Kaplan and Fink2found that as high as 8 per cent of their pernicious anemia patients developed gastric carcinoma, and an additional 7 per cent had gastric polyps, making a total incidence of 15 per cent of their series with malignant or premalignant gastric lesions....Bibliography1. Quincke H: Ueber perniciöse Anämie, 1876, Druck und Verlag von Breitkopf und Hartel, Leipzig, pp. 797-818. Google Scholar2. RiglerKaplanFink LGHSDL: Pernicious anemia and early diagnosis of tumors of stomach, J. A. M. A. 128: 426-432 (June 9) 1945. CrossrefGoogle Scholar3. KaplanRigler HSLG: Pernicious anemia and carcinoma of stomach—autopsy studies concerning their interrelationship, Am. J. M. Sc. 209: 339-348 (Mar.) 1945. CrossrefGoogle Scholar4. StateGlaviserHubbardWangensteen DDTBOH: Early diagnosis of gastric cancer, J. A. M. A. 142: 1128-1133 (Apr. 15) 1950. CrossrefGoogle Scholar5. St. JohnSwensonHarvey FBPCHD: Experiment in early diagnosis of gastric carcinoma, Ann. Surg. 119: 225-231 (Feb.) 1944. CrossrefMedlineGoogle Scholar6. GiffinBowler HZJP: Diseases which may be associated with pernicious anemia, Minnesota Med. 6: 13-16 (Jan.) 1923. Google Scholar7. Strandell B: Pernicious anemia; study of 117 cases, Acta med. Scandinav. supp. 40, pp. 1-124, 1931. Google Scholar8. Wilkinson JF: Diseases associated with pernicious anemia in study of 370 cases, Quart. J. Med. 2: 281-309 (July) 1933. Google Scholar9. ConnerBirkeland HMIW: Coexistence of pernicious anemia and lesions of gastrointestinal tract; carcinoma of stomach; consideration of 20 cases: 11 reported, Ann. Int. Med. 7: 89-104 (July) 1933. LinkGoogle Scholar10. Brown MR: Pathology of gastro-intestinal tract in pernicious anemia and subacute combined degeneration of spinal cord; study of 151 autopsies, New England J. Med. 210: 473-477 (Mar. 1) 1934. CrossrefGoogle Scholar11. MurphyHoward WPI: Analysis of complications occurring in series of patients with pernicious anemia, Rev. Gastroenterol. 3: 98-110 (June) 1936. Google Scholar12. WashburnRozendaal RNHM: Gastric lesions associated with pernicious anemia, Ann. Int. Med. 11: 2172-2180 (June) 1938. Google Scholar13. Jenner AW: Perniziöse Anämie und Magenkarzinom, Acta brev. Neerland. 9: 123-124, 1939. Google Scholar14. DoehringEusterman PCGB: Association of pernicious anemia and carcinoma of stomach, Arch. Surg. 45: 554-563 (Oct.) 1942. CrossrefGoogle Scholar15. JankelsonMcClureFreedberg IRCWH: Relation of atrophic gastric mucosa to carcinoma of stomach, Rev. Gastroenterol. 10: 26-31 (Jan.-Feb.) 1943. Google Scholar16. Myers F: Vagaries in diagnosis and treatment of pernicious anemia, Ohio State M. J. 40: 635-638 (July) 1944. Google Scholar17. Frank TJ: Macrocytic anaemia and gastric lesions, Roy. Melbourne Hosp. Clin. Rep. 15: 12-34 (Dec.) 1944. Google Scholar18. RiglerKaplan LGHS: Pernicious anemia and tumors of the stomach, J. Nat. Cancer Inst. 7: 327-332 (Apr.) 1947. MedlineGoogle Scholar19. Wallace AW: Pernicious anemia and its relationship to carcinoma of the stomach, Bull. Vancouver M. A. 24: 162-163 (Feb.) 1948. MedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Boston, Massachusetts*Received for publication February 9, 1952.From the Department of Internal Medicine of the Lahey Clinic, Boston. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byHigh-Risk Gastric Pathology and Prevalent Autoimmune Diseases in Patients with Pernicious AnemiaAutoimmune gastritis: Pathologist’s viewpointSystematic review: gastric cancer incidence in pernicious anaemiaDevelopment of gastric dysplasia in pernicious anaemia: a clinical and endoscopic follow up study of 80 patients.MagenDie megaloblastischen AnämienAtrophic Gastritis as a Possible Precursor of Gastric Carcinoma and Pernicious Anemia Results of follow-up examinationsPernicious Anemia and Gastric Carcinoma.Anemia In CancerMechanisms of Anemia in CancerOccurrence of Gastric Cancer among Patients with Pernicious Anemia at the Boston City HospitalCarcinoma of the stomach. A review of 161 cases treated at the new haven hospital from January, 1941, to December, 1946, and a comparison with two previous series, 1920-1930 and 1931-1940 1 August 1952Volume 37, Issue 2Page: 338-343KeywordsLesionsPernicious anemiaStomach ePublished: 1 December 2008 Issue Published: 1 August 1952 PDF downloadLoading ...