THE TREATMENT OF HEMOCHROMATOSIS BY MASSIVE VENESECTION
Authors: W D DAVIS, W R ARROWSMITH
Journal: Annals of Internal Medicine (1953)

Article1 October 1953THE TREATMENT OF HEMOCHROMATOSIS BY MASSIVE VENESECTIONW. D. DAVIS JR., M.D., F.A.C.P., W. R. ARROWSMITH, M.D.W. D. DAVIS JR., M.D., F.A.C.P., W. R. ARROWSMITH, M.D.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-39-4-723 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptHemochromatosis is a rare disease characterized clinically by the triad of cirrhosis, diabetes and bronzing of the skin. The pathologic picture is one of massive accumulation of iron pigment throughout the tissues, with particular concentration in the epithelial glands and especially the liver and pancreas.1 The lymph nodes, heart, adrenals and testes are also frequently involved. The clinical course and gross and microscopic pathologic characteristics are well known.The etiology and pathologic physiology are far less factually established, although recent investigations have yielded fairly convincing evidence as to its pathogenesis. Contrary to earlier conclusions,2there is now sound evidence that...Bibliography1. Sheldon JH: Hemochromatosis, 1935, Oxford University Press, London. Google Scholar2. MarbleSmith ARM: Studies of iron metabolism in a case of hemochromatosis, Ann. Int. Med. 12: 1592, 1939. LinkGoogle Scholar3. RathFinch CECA: Chemical, clinical and immunological studies on the products of human plasma fractionation. XXXVIII. Serum iron transport. Measurement of iron-binding capacity of serum in man, J. Clin. Investigation 28: 79, 1949. CrossrefGoogle Scholar4. HoustonThompson JCRH: The diagnostic value of serum iron studies in hemochromatosis; observations on seven patients, Quart. J. Med. 21: 215, 1952. MedlineGoogle Scholar5. DubachCallenderMoore RSTCV: Studies in iron transportation and metabolism; absorption of radioactive iron in patients with fever and with anemia of varied etiology, Blood 3: 526, 1948. CrossrefMedlineGoogle Scholar6. Granick S: Iron metabolism and hemochromatosis, Bull. New York Acad. Med. 25: 403, 1949. MedlineGoogle Scholar7. KinneyHegstedFinch TDDMCA: The influence of diet on iron absorption; the pathology of iron excess, J. Exper. Med. 90: 137, 1949. CrossrefMedlineGoogle Scholar8. HegstedFinchKenney DMCATD: The influence of diet on iron absorption; the interrelation of iron and phosphorus, J. Exper. Med. 90: 147, 1949. CrossrefMedlineGoogle Scholar9. AdamsLeslieLevin WSAMH: The dermal loss of iron, Proc. Soc. Exper. Biol. and Med. 74: 46, 1950. CrossrefMedlineGoogle Scholar10. Houston JC: Hemochromatosis and refractory anaemia, Guy's Hosp. Rep. 100: 355, 1951. MedlineGoogle Scholar11. WallersteinRobbins ROSL: Hemochromatosis after prolonged oral iron therapy in a patient with chronic hemolytic anemia, Am. J. Med. 14: 256, 1953. CrossrefMedlineGoogle Scholar12. FinchHegstedKinneyThomasRathHaskinsFinchFluharty CAMTDEDCEDSRG: Iron metabolism and the pathophysiology of iron storage, Blood 5: 983, 1950. CrossrefMedlineGoogle Scholar13. WyattGoldenberg JPH: Hemosiderosis in refractory anemia, Arch. Int. Med. 83: 67, 1949. CrossrefGoogle Scholar14. Finch C: Personal communication. Google Scholar15. GillmanGillman JT: Structure of the liver in pellagra, Arch. Path. 40: 239, 1945. Google Scholar16. GillmanGillman JT: The pathogenesis of cytosiderosis (hemochromatosis) as evidenced in malnourished Africans, Gastroenterology 8: 19, 1947. MedlineGoogle Scholar17. WalkerArvidsson ARUB: Iron intake and hemochromatosis in the Bantu, Nature, London 166: 438, 1950. CrossrefMedlineGoogle Scholar18. AlthausenDoigWeidenMotteramTurnerMoore TLRKSRCNA: Hemochromatosis; investigation of twenty-three cases, with special reference to etiology, nutrition, iron metabolism and studies of hepatic and pancreatic function, Arch. Int. Med. 88: 553, 1951. CrossrefGoogle Scholar19. MarbleBailey ACC: Hemochromatosis, Am. J. Med. 11: 590, 1951. CrossrefMedlineGoogle Scholar20. BalfourHahnBalePommerenkeWhipple WMPFWFWTCH: Radio iron absorption in clinical conditions; normal, pregnancy, anemia and hemochromatosis, J. Exper. Med. 76: 15, 1942. CrossrefMedlineGoogle Scholar21. SchwartzBlumenthal SOSA: Exogenous hemochromatosis resulting from blood transfusions, Blood 3: 617, 1948. CrossrefMedlineGoogle Scholar22. DavisArrowsmith WDWR: The effect of repeated phlebotomies in hemochromatosis, J. Lab. and Clin. Med. 39: 526, 1952. MedlineGoogle Scholar23. DavisLaurens WDH: Correlation of results of liver function tests and liver biopsy in hepatic disease, South. M. J. 43: 217, 1950. CrossrefMedlineGoogle Scholar24. Davis WD: Needle biopsy of the liver, New Orleans M. and S. J. 100: 159, 1947. MedlineGoogle Scholar25. ToppLindert JHMC: The diagnosis of hemochromatosis by means of needle biopsy of the liver, Gastroenterology 10: 813, 1948. MedlineGoogle Scholar26. HowardWatson RBCJ: Personal communication. Google Scholar27. Urenn BM: When patients are doctors, 1952, W. W. Norton & Co., New York, p. 238. Google Scholar28. FinchFinch SCC: Personal communication. Google Scholar29. Anzinger FW: Personal communication. Google Scholar30. BeyersGitlow MRSE: Metabolism of iron in hemochromatosis, Am. J. Clin. Path. 21: 349, 1951. CrossrefMedlineGoogle Scholar31. Eusterman GB: Hemochromatosis, M. Clin. North America 11: 1376, 1928. Google Scholar32. ButtWilder HRRM: Hemochromatosis; report of 30 cases in which the diagnosis was made during life, Arch. Path. 26: 262, 1938. Google Scholar33. Barker LF: Control of diabetes in hemochromatosis; remarkable improvement in the strength and working capacity of a patient with decrease of his pigmentation under diet and insulin, M. Clin. North America 14: 177, 1930. Google Scholar34. FederGitmanHoffman IAIJB: Hemochromatosis, Rev. Gastroenterol. 17: 1048, 1950. MedlineGoogle Scholar35. Lawrence RD: Hemochromatosis, Proc. Roy. Soc. Med. 43: 356, 1950. MedlineGoogle Scholar36. Lawrence RD: The prognosis of hemochromatosis, Lancet 2: 1171, 1936. CrossrefGoogle Scholar37. Polson C: The failure of prolonged administration of iron to cure hemochromatosis, Brit. J. Exper. Path. 14: 73, 1933. Google Scholar38. WarrenDrake SWI: Primary carcinoma of the liver in hemochromatosis, Am. J. Path. 27: 573, 1951. MedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: New Orleans, Louisiana*Presented at the Thirty-Fourth Annual Session of the American College of Physicians, Atlantic City, New Jersey, April 16, 1953.From the Departments of Internal Medicine, Ochsner Clinic and Tulane University of Louisiana School of Medicine, New Orleans. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byPractical Management of Iron Overload Disorder (IOD) in Black Rhinoceros (BR; Diceros bicornis)Hepcidin in Iron Homeostasis: Diagnostic and Therapeutic Implications in Type 2 Diabetes Mellitus PatientsArvelig hemokromatose gjennom 150 årDeferasirox in patients with iron overload secondary to hereditary hemochromatosis: results of a 1-yr Phase 2 studyIron restriction prevents diabetic nephropathy in Otsuka Long-Evans Tokushima fatty ratScreening for hereditary haemochromatosisThe role of iron in type 2 diabetes in humansPraise ye the god of iron1Hierro, resistencia a la insulina y riesgo cardiovascularInsulin signaling, glucose metabolism oxidative stress, and agingCross-Talk Between Iron Metabolism and DiabetesResistencia a la insulina relacionada con el hierroHereditary iron overload and African Americans5 Haemochromatosis and diabetesA History of Phlebotomy Therapy for HemochromatosisSouthern Blood Club Symposium: An Update On Selected Aspects of HemochromatosisIron OverloadHereditary HaemochromatosisMyocardial involvement in idiopathic hemochromatosisTreatment of iron overload in adults with continuous parenteral desferrioxamineReassessment of the Use of Desferrioxamine B in Iron OverloadThe PancreasObservations on the pathogenesis, complications and treatment of diabetes in 115 cases of haemochromatosisReversal of "Cirrhosis" in Idiopathic Haemochromatosis Following Long-term Intensive Venesection TherapyThe Treatment of Hemochromatosis by PhlebotomyThe Reversal of Hemochromatotic Cirrhosis by Multiple PhlebotomiesIron Chelation with Deferoxamine in Hepatic DiseasePortal hypertension in hemochromatosisEXOGENOUS HEMOCHROMATOSIS and TRANSFUSIONAL SIDEROSIS REPORT OF THREE CASESThe Treatment of Cirrhosis of the LiverManagement of Familial HemochromatosisA familial study in idiopathic hemochromatosisDas PankreasSOME ASPECTS OF IRON METABOLISMMILTON S. SACKS, M.D. 1 October 1953Volume 39, Issue 4Page: 723-734KeywordsAttentionCirrhosisEtiologyHeartHemochromatosisLiverLymph nodesPathogenesisPhlebotomyTestes ePublished: 1 December 2008 Issue Published: 1 October 1953 PDF downloadLoading ...