TOXIC REACTION TO MERCAPTOMERIN (THIOMERIN): CASE REPORT
Authors: R L SEGAL
Journal: Annals of Internal Medicine (1955)

Case Reports1 August 1955TOXIC REACTION TO MERCAPTOMERIN (THIOMERIN): CASE REPORTROBERT LLOYD SEGAL, M.D.ROBERT LLOYD SEGAL, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-43-2-435 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptOf all diuretic drugs, the mercurial diuretics have the established advantage of combining effectiveness and safety when administered intramuscularly.1 They may on occasion cause local or generalized reactions of varying degree. Chemical modifications of these organic mercurial compounds have been employed in an effort to minimize such toxic effects.2, 3 Another mercurial compound, mercaptomerin sodium (Thiomerin) has recently been introduced. This preparation is an organic mercurial combined with a mercaptan (disodium salt of N-(gamma-carboxy-methyl-mercaptomercuri-beta-methoxy) propyl camphoramic acid). Formula: C(CH3), C(COONa) (CH3), CH2, CH2, CH(ONH CH2) CH (OCH2) CH2HgSCH2.The stated clinical characteristics of mercaptomerin are:1. It is an effective...Bibliography1. GoodmanGilman LA: The pharmacological basis of therapeutics, 1941, The Macmillan Company, New York. Google Scholar2. LehmanTaubeKing RAHEE: A comparative study of the local toxic action of the mercurial diuretics, Proc. Soc. Exper. Biol. and Med. 71: 1-6, 1949. CrossrefMedlineGoogle Scholar3. DeGraffNadler ACJF: A review of the toxic manifestations of mercurial diuretics in man, J. A. M. A. 119: 1006 (July 25) 1942. CrossrefGoogle Scholar4. BattermanUntermanDeGraff RCDAC: The subcutaneous administration of mercaptomerin (Thiomerin), J. A. M. A. 140: 1268 (Aug. 20) 1949. CrossrefMedlineGoogle Scholar5. StewartMcCoyShepardLuckey HJHIEMEH: Experience with Thiomerin—a new mercurial diuretic, Circulation 1: 502 (Mar.) 1950. CrossrefGoogle Scholar6. Robbins MH: Systemic sensitivity to various mercurial diuretics, New York State J. Med. 52: 593-594 (Mar. 1) 1952. MedlineGoogle Scholar7. WeissmanGelfand LHH: Mercaptomerin sensitivity: report of a case, J. A. M. A. 147: 1559 (Dec. 15) 1951. CrossrefMedlineGoogle Scholar8. SilvermanWorthen JJJF: Agranulocytosis in a patient treated with mercurial diuretics, J. A. M. A. 148: 200 (Jan. 19) 1952. CrossrefMedlineGoogle Scholar9. WhitmanProudfit JFR: Hypersensitivity to Mercuhydrin, Circulation 6: 245 (Aug.) 1952. CrossrefMedlineGoogle Scholar10. BurrowsStokes AW: Mercurial diuretics: intolerance as shown by skin sensitivity, Brit. Heart J. 7: 161 (Oct.) 1945. CrossrefGoogle Scholar11. AbramowitzNoun EWMH: Fixed drug eruptions, Arch. Dermat. and Syph. 35: 875 (May) 1937. CrossrefGoogle Scholar12. Abramowitz EW: Role of allergy in drug eruptions, New York State J. Med. 37: 128 (Jan. 15) 1937. Google Scholar13. Abramowitz EW: Cardinal points in the diagnosis of drug eruptions, M. Clin. North America 22: 1323 (Sept.) 1938. CrossrefGoogle Scholar14. Ackroyd JF: Allergic purpura including purpura due to foods, drugs and infections, Am. J. Med. 14: 605 (May) 1953. CrossrefMedlineGoogle Scholar15. SnellRowntree AMLG: Purpuric skin manifestations following the use of Merbaphen, Ann. Int. Med. 2: 97, 1928. LinkGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: New York, N. Y.*Received for publication July 3, 1954. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byQuecksilberhaltige DiureticaBIBLIOGRAPHYTriazine Mercurial Diuretics**Research Laboratories of the U. S. Vitamin Corporation, Yonkers, N. Y.REACTIONS TO THE ORGANOMERCURIAL COMPOUNDSMetalle 1 August 1955Volume 43, Issue 2Page: 435-441KeywordsAtrial fibrillationDiureticsDrug safetyDrugsGratitudePenisSafetySaltsSodiumStenosis Issue Published: 1 August 1955 PDF downloadLoading ...