tbuckley/cabot-search huggingface dataset:
Cytological types of lung cancer in a referral population in Western Greece during the past decade
Authors: Dimosthenis Lykouras, Nikolaos Mparampatis, Olga Lagiou, Vasiliki Apollonatou, Maria Tsiamita, Apostolos Voulgaridis, Kiriakos Karkoulias, Kostas Spiropoulos
Journal: European Respiratory Journal (2014)

Introduction: The aim of this study was to demonstrate the cytology results of both bronchial washing and post-bronchoscopy sputum specimens of patients suspected to have a type of malignancy.

Materials and methods: We collected cytological results of 954 patients (747 men and 207 women) diagnosed with lung cancer during the years 2002-2013. The symptoms that were more frequently reported prior to bronchoscopy were haemoptysis, chronic cough, dyspnea and chest pain.

Results: The following table illustrates the type of malignancy found in cytology tests

View this table:

Type of malignancy





.

Discussion: The most common type of malignancy in the population that was investigated was squamous cell carcinoma with a rate of 36,8%, followed by adenocarcinoma 34,3%. The patients that were found to have small cell lung carcinoma (SCLC) were fewer (16,0%), while there are patients reported with other types of endobronchial lesions (12,9%) such as large cell carcinoma, benign tumors etc. About 60% of the male patients were smokers and 75% of them were heavy smokers (over 40 packs/year). About 45% of female patients were smokers and 20% of those were heavy smokers. The ratio between men:women was 3,6:1.
Myocardial Gene Expression in Heart Failure Patients Treated With Cardiac Resynchronization Therapy
Authors: Marc Vanderheyden, Wilfried Mullens, Leen Delrue, Marc Goethals, Bernard de Bruyne, William Wijns, Peter Geelen, Sofie Verstreken, Francis Wellens, Jozef Bartunek
Journal: Journal of the American College of Cardiology (2008)
Intensive care of patients with tuberculosis
Authors: Aliaksandr Skrahin, Maryna Dziusmikeyeva, Aleh Prasmytski, Dmitri Pechinski, Varvara Slodovnikova, Viktoryia Kralko, Andrei Astrauko, Alena Skrahina
Journal: European Respiratory Journal (2011)

Introduction: Multi and extensively drug resistance (MDR, XDR), HIV association, these nowadays TB phenomena related to long and aggressive chemotherapy, frequent disease progressions and complications, elective and emergency surgery lead to increase in intensive care (IC) requirement for TB patients.

Aim: The aim of the study was to describe the characteristics of patients with TB requiring IC, to evaluate the risk factors for intensive care unit (ICU) admission, and to identify the factors that predict ICU mortality.

Patients and methods: Patients with TB admitted to the National Research and Practical Centre for Pulmonology and TB (Centre) during one year (2010) entered the study. Demographic, clinical, radiological and bacteriological data at hospital admission and during ICU stay were recorded, and risk factors for ICU admission and death were calculated.

Results: A total of 1001 TB patients were admitted to the Centre during the study period. 280 of them had MDR-TB, 78 – XDR-TB and 20 – HIV-TB co-infection. 144 TB patients were admitted to ICU, in 43 of them admission was related to surgery. 31 patients died giving 21.5% of ICU mortality rate. Factors significantly related to ICU admission were: previous TB treatment, history of imprisonment, MDR and XDR of discharging Mycobacterium tuberculosis, HIV co-infection, and excessive alcohol use. Risk factors for ICU death were: low body mass index, pulmonary co-morbidity, disseminated disease with CNS involvement, previous ICU admission.

Conclusions: These data indicate a relatively high requirement in IC as well as high ICU mortality of TB patients. Our results can contribute to a better understanding of characteristics associated with IC and mortality for TB patients.
Sublimiting concentration of TFIIH transcription/DNA repair factor causes TTD-A trichothiodystrophy disorder
Authors: Wim Vermeulen, Etienne Bergmann, Jérôme Auriol, Suzanne Rademakers, Philippe Frit, Esther Appeldoorn, Jan H.J. Hoeijmakers, Jean-Marc Egly
Journal: Nature Genetics (2000)
Color Atlas of Cancer Cytology.
Authors: 正宜 高橋
Journal: Annals of Internal Medicine (1972)

Part 1 General cancer cytology: diagnostic immunocytochemistry for evaluation of human tumours, Robert M. Nakamura, Gerald M. Bordin cytologic DNA content and cell cycle analysis, Richard J. Clatch X chromatin Y chromatin fluorescence in situ hybridisation (FISH). Part 2 Practical cytology of organs: female genital tract breast, Masayoshi Takahashi, Masahiko Fujii respiratory tract thyroid thymus and mediastinum, Masayoshi Takahashi, Toshiro Kawai salivary glands, Masayoshi Takahashi, Toshiro Kawai oesophagus and intestines liver, bile ducts and pancreas, Kunio Mizuguchi effusions in body cavities urinary prostate lymph node prognostic markers in malignant lymphoma, Thomas M. Grogan bone and bone marrow central nervous system skin and its related mucous membrane telepathology and telecytology.
Herbal remedies: Patient heal thyself
Authors: H. Goodare
Journal: BMJ (1998)

Recently I undertook a sponsored pilgrimage from Horsham to Canterbury in aid of two local charities. We were aiming to walk over 100 miles, mostly along the North Downs Way, averaging 15 miles a day for eight days.

After two days I wasn't too much the worse for wear, with only minor blisters. We were taking turns to lead the walk, and my turn was to be on the last day, leading a few extra day trippers into Canterbury itself. I was looking forward to that, and to getting my own back on the mostly younger men who were leading on the other days and obviously did not think …
Renal Adaptation to a High Potassium Intake
Authors: Richard L. Tannen, Eric Wedell, Ronda Moore
Journal: Journal of Clinical Investigation (1973)

The influence on urinary acidification of prolonged ingestion of a high potassium diet was explored in normal men and dogs. In men, the response to acute ingestion of ammonium chloride was assessed in a paired fashion after 5 days of ingesting a formula diet of normal or high potassium content; whereas in animals chronically ingesting a small amount of hydrochloric acid, the response to an increase in daily potassium intake was assessed. Urine pH was lower in the potassium-loaded state with both these models, and the effect persisted in the dog studies as long as a high potassium intake was continued. The decrease in urine pH could not be accounted for by changes in plasma acid-base status, net acid excretion, rate of urine flow, urine ionic strength, or fixed buffer excretion, i.e., phosphate, creatinine, or organic acids. Studies of men with administration of exogenous aldosterone and studies of adrenalectomized dogs with constant, maintenance steroid replacement indicated that the decrease in urine pH does not result from altered aldosterone secretion.
Case 2-2015
Authors: Mandakolathur R. Murali, Jennifer W. Uyeda, Bhatraphol Tingpej
Journal: New England Journal of Medicine (2015)

A 25-year-old man was admitted to the hospital because of abdominal pain, syncope, and hypotension that occurred while he was lifting heavy boxes. An abdominal ultrasound examination revealed a hypoechoic lesion in the liver. A diagnostic test was performed.
Alteration of the fecal microbiota and serum metabolite profiles in dogs with idiopathic inflammatory bowel disease
Authors: Yasushi Minamoto, Cristiane C Otoni, Samantha M Steelman, Olga Büyükleblebici, Jörg M Steiner, Albert E Jergens, Jan S Suchodolski
Journal: Gut Microbes (2015)

Idiopathic inflammatory bowel disease (IBD) is a common cause of chronic gastrointestinal (GI) disease in dogs. The combination of an underlying host genetic susceptibility, an intestinal dysbiosis, and dietary/environmental factors are suspected as main contributing factors in the pathogenesis of canine IBD. However, actual mechanisms of the host-microbe interactions remain elusive. The aim of this study was to compare the fecal microbiota and serum metabolite profiles between healthy dogs (n = 10) and dogs with IBD before and after 3 weeks of medical therapy (n = 12). Fecal microbiota and metabolite profiles were characterized by 454-pyrosequencing of 16 S rRNA genes and by an untargeted metabolomics approach, respectively. Significantly lower bacterial diversity and distinct microbial communities were observed in dogs with IBD compared to the healthy control dogs. While Gammaproteobacteria were overrepresented, Erysipelotrichia, Clostridia, and Bacteroidia were underrepresented in dogs with IBD. The functional gene content was predicted from the 16 S rRNA gene data using PICRUSt, and revealed overrepresented bacterial secretion system and transcription factors, and underrepresented amino acid metabolism in dogs with IBD. The serum metabolites 3-hydroxybutyrate, hexuronic acid, ribose, and gluconic acid lactone were significantly more abundant in dogs with IBD. Although a clinical improvement was observed after medical therapy in all dogs with IBD, this was not accompanied by significant changes in the fecal microbiota or in serum metabolite profiles. These results suggest the presence of oxidative stress and a functional alteration of the GI microbiota in dogs with IBD, which persisted even in the face of a clinical response to medical therapy.
THE POSTGRADUATE PORTION OF MEDICAL EDUCATION
Authors: C. Sidney Burwell
Journal: Annals of Internal Medicine (1939)

Article1 August 1939THE POSTGRADUATE PORTION OF MEDICAL EDUCATIONC. SIDNEY BURWELL, M.D., F.A.C.P.C. SIDNEY BURWELL, M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-13-2-339 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe annual session of the American College of Physicians is an appropriate place to discuss this subject of medical education. These Fellows of the College are themselves all students; their purpose in attending this meeting is to study medicine; the meeting represents an important variety of medical education.When our President honored me with his invitation to discuss the graduate phase of medical education, he in effect asked me this question: "What do you think about this problem?" My answer, such as it is, represents my own conclusion and is not to be taken as implicating any faculty, committee, or... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Boston, Massachusetts*Read at the New Orleans meeting of the American College of Physicians, March 27, 1939. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 August 1939Volume 13, Issue 2Page: 339-344KeywordsGraduate medical educationMedical education ePublished: 1 December 2008 Issue Published: 1 August 1939 PDF downloadLoading ...
Risk Factors for Cardiovascular Disease in Women—Reply
Authors: Paul M Ridker, Julie E. Buring
Journal: JAMA (2005)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Abstract IA18: ERK activity in mutant BRAF melanoma – A live report
Authors: Andrew E. Aplin
Journal: Clinical Cancer Research (2015)

Abstract The response of BRAF V600E/K melanoma patients to either RAF inhibitors or the RAF/MEK inhibitor combination is heterogeneous and short-term responses are associated with acquired resistance. Our previous studies have implicated compensatory FOXD3-ERBB3-AKT signaling as an adaptive response to targeted inhibition of the ERK1/2 pathway. While adaptive responses likely modulate the initial tumor response to targeted inhibitors, stable changes drive acquired resistance leading to the re-growth of tumors that initially responded to RAF inhibitors. Outgrowth of resistant cells may be due to the acquisition of a secondary mutation and/or selection of pre-existing cells harboring genetic alterations that negate the effect of RAF inhibitors. To model acquired resistance to RAF inhibitors, we developed mutant BRAF melanoma ERK1/2 activity reporter xenograft models. This system enables quantitative analysis of ERK1/2 activity in response to pathway inhibitors across the whole tumor in a temporal manner. We have utilized this system to analyze the initial response to RAF inhibitors in vivo, as well as re-activation of the ERK1/2 pathway associated with acquired resistance. Furthermore, we are utilizing this model to analyze response and resistance to RAF/MEK inhibitor combinations and next-generation RAF inhibitors. Citation Format: Andrew E. Aplin. ERK activity in mutant BRAF melanoma – A live report. [abstract]. In: Proceedings of the AACR Precision Medicine Series: Drug Sensitivity and Resistance: Improving Cancer Therapy; Jun 18-21, 2014; Orlando, FL. Philadelphia (PA): AACR; Clin Cancer Res 2015;21(4 Suppl): Abstract nr IA18.
Abstract 16902: Depressive Symptoms Mediate the Relationship between Perceived Control and Quality of Life in Patients with Heart Failure and their Family Caregivers
Authors: Misook L Chung, Terry A Lennie, Debra K Moser
Journal: Circulation (2014)

Background:  Depressive symptoms are common and associated with poor quality of life in patients with heart failure (HF) and their family caregivers. Perceived control over management of HF is associated with both depressive symptoms and quality of life for both patients and caregivers. The purpose of this study was to examine whether the relationship between perceived control and quality of life was mediated by depressive symptoms.   Methods:  A total of 128 patients with HF and their family caregivers completed questionnaires in which depressive symptoms, perceived control, and quality of life were assessed using the Patient Health Questionnaire, Cardiac Attitude Index, and SF-12. A series of multiple regressions were used to determine mediation effect of depressive symptoms in patients and caregivers separately. Significant test of mediation effect (i.e., indirect effect) was examined by Sobel z-score testing.   Results:  Perceived control was associated with quality of life and depressive symptoms for patients and caregivers. When depressive symptoms were added into the prediction model for quality of life, the significant relationship between perceived control and quality of life disappeared as shown by changes from C to C’ in Figure 1 in both patients and caregivers. The mediation effects of depressive symptoms were significant and high as 88% and 63% of total effect for patient and caregivers, respectively.   Conclusion:  This study demonstrated that perceived control is critical in quality of life for both patients and caregivers. The significant mediation effect of depressive symptoms on this relationship more clearly provides direction for interventions to improve quality of life in dyads.
International phase 3 study of azacitidine vs conventional care regimens in older patients with newly diagnosed AML with &gt;30% blasts
Authors: Hervé Dombret, John F. Seymour, Aleksandra Butrym, Agnieszka Wierzbowska, Dominik Selleslag, Jun Ho Jang, Rajat Kumar, James Cavenagh, Andre C. Schuh, Anna Candoni, Christian Récher, Irwindeep Sandhu, Teresa Bernal del Castillo, Haifa Kathrin Al-Ali, Giovanni Martinelli, Jose Falantes, Richard Noppeney, Richard M. Stone, Mark D. Minden, Heidi McIntyre, Steve Songer, Lela M. Lucy, C. L. Beach, Hartmut Döhner
Journal: Blood (2015)
Abstract 9028: Endogenous Digitalis-Like Compounds May Regulate Cardiac Hypertrophy/Failure
Authors: Lijun Liu, Marjorie Gable, Zijian Xie, Jerry B Lingrel, Amir Askari
Journal: Circulation (2010)

We showed before that in isolated cardiac myocytes, digitalis binding to NaK- ATPase α1 isoform initiates selective activation of the class 1A PI3K/Akt signaling pathways, causing myocyte hypertrop...
A Visit From My Daughter
Authors: D H Sakai
Journal: JAMA (1998)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Abstract 958: Activation of COL11A1 by anticancer drugs through IGF-1R/PI3K pathway confers chemoresistance in ovarian cancer via activating NF-κB-mediated Twist1 expression
Authors: Yi-Hui Wu, Yu-Fang Huang, Cheng-Yang Chou
Journal: Cancer Research (2014)

Abstract Epithelial ovarian carcinoma remains the most lethal gynecologic malignancy. While initial response to first-line therapy (consisting of surgical cytoreduction and combination platinum/taxane therapy) is usually effective, the majority of patients will ultimately recur with chemotherapy-resistant cancer and succumb to disease. Biomarkers that predict patient's responsiveness to chemotherapy might assist the development of better therapeutic strategies for aggressive cancers, such as ovarian cancer. Here, we investigated the molecular mechanisms of collagen type XI alpha 1 (COL11A1) in chemo-resistance of ovarian cancer. We analyzed the expression profiles of 60 epithelial ovarian cancer tissue samples obtained at first cytoreductive surgery to identify genes linked with chemotherapy response. Among the 47 selected genes, collagen type XI alpha 1 (COL11A1) was the most highly elevated in chemo-resistance tumors. Small interference RNA-mediated specific reduction in COL11A1 protein levels increased the sensitivity to cisplatin and taxol in ovarian cancer cells. A combination of experimental approaches, including real-time RT-PCR, western blotting, luciferase assay and chromatin immunoprecipitation (ChIP) assays, showed that COL11A1 knockdown attenuated Twist1 expression and suppressed binding of NF-κB to its putative Twist1 promoter binding site, suggesting that the NF-κB/Twist1 axis is upregulated by COL11A1. Cisplatin and taxol treatment triggers the activation of IGF-1R/PI3K signaling cascades, leading to activation of COL11A1 and Twist1. Pharmacological inhibition of PI3K abrogated the cisplatin and taxol-triggered, COL11A1-dependent chemo-resistance. Furthermore, the c/EBPβ binding site on the COL11A1 promoter was identified as the major determinant of cisplatin and taxol-dependent COL11A1 activation. Analysis of 88 ovarian cancer patients indicated that high COL11A1 mRNA levels are significantly associated with high Twist1 mRNA levels and poor clinical outcome. We conclude that activation of COL11A1 by anti-cancer drugs through IGF-1R/PI3K pathway confers chemo-resistance in ovarian cancer cells via activating NF-κB-mediated Twist1 expression. Citation Format: Yi-Hui Wu, Yu-Fang Huang, Cheng-Yang Chou. Activation of COL11A1 by anticancer drugs through IGF-1R/PI3K pathway confers chemoresistance in ovarian cancer via activating NF-κB-mediated Twist1 expression. [abstract]. In: Proceedings of the 105th Annual Meeting of the American Association for Cancer Research; 2014 Apr 5-9; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2014;74(19 Suppl):Abstract nr 958. doi:10.1158/1538-7445.AM2014-958
Abstract P317: Serum Soy Isoflavones Are Inversely Associated With Coronary Artery Calcification In A Population-based Sample Of 299 Men In Japan
Authors: Akira Sekikawa, Katsuyuki Miura, Abhishek Vishnu, Akira Fujiyoshi, Rhobert W Evans, Takashi Kadowaki, Daniel Edmundowicz, Takashi Hisamatsu, Vasudha Ahuja, Hiroshi Maegawa, Marianne Bertolet, Kiyoshi Murata, Tomonori Okamura, Emma J Barinas-Mitchell, Yasuyuki Nakamura, Lewis H Kuller, Hirotsugu Ueshima
Journal: Circulation (2014)

Objectives: Epidemiological studies in Asia where consumption of soy isoflavones (ISF) are regular and high implicated that isoflavones are protective against coronary heart disease (CHD), especially in post-menopausal women. There is a lack of data on the association of isoflavones with atherosclerosis, especially in men. We aim to determine a cross sectional association of serum ISF with coronary artery calcification (CAC) in men in Japan. Methods: A population-based sample of 299 men aged 40-49 years in Japan was examined for CAC and other risk factors in 2002-06. Electron-beam CT was used to evaluate CAC. Stored serum samples were analyzed for ISF (genistein and daidzein). We defined serum ISFs as the sum of genistein and daidzein. Presence of CAC was defined as coronary calcium score ≥ 10. Because the distribution of serum ISF is skewed, we evaluated quartile of serum ISF and analyzed the association of ISF with the presence of CAC using a general linear model. Findings: The median value (interquartile range) of ISF was 517 (195, 1,147) nM/l. Serum ISF had a significant inverse association with CAC in crude analysis. After adjusting for age, LDL-C, smoking, and BMI, each of which had a significant univariate association with CAC, the inverse association of ISF with CAC remained, with littel change in point estimates. After further adjusting for other risk factors as well as serum levels of long-chain n-3 polyunsaturated fatty acids, the inverse association remained. Conclusions: Serum levels of ISF in Japanese men in Japan had an inverse association of CAC, suggesting that ISF at the levels Japanese in Japan regularly consume have anti-atherogenic properties in men.
Comprehensive analysis of factors impacting risks and outcomes of therapy-related myeloid neoplasms following breast cancer treatment
Authors: K Sevcikova, Z Zhuang, G Garcia-Manero, R H Alvarez, H M Kantarjian, M Mego, C Albarracin, G Tang, S S Strom, L J Medeiros, G N Hortobagyi, J M Reuben, J D Khoury
Journal: Leukemia (2015)