Hypothalamic Endocrinopathy in Hand-Schüller-Christian Disease
Authors: JEFFREY G. ROTHMAN
Journal: Annals of Internal Medicine (1978)

Brief Reports1 April 1978Hypothalamic Endocrinopathy in Hand-Schüller-Christian DiseaseJEFFREY G. ROTHMAN, M.D., PETER J. SNYDER, M.D., ROBERT D. UTIGER, M.D.JEFFREY G. ROTHMAN, M.D.Search for more papers by this author, PETER J. SNYDER, M.D.Search for more papers by this author, ROBERT D. UTIGER, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-88-4-512 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptHand-SchÜller-Christian disease is characterized by infiltration of multiple organs by well-differentiated histiocytes. Diabetes insipidus is a well-known manifestation of this disease, and anterior pituitary hormone deficiencies also occur (1). We describe a patient with Hand-Schüller-Christian disease whose hypothalamic-pituitary function was tested extensively. The results support the hypothesis that Hand-Schüller-Christian disease causes a hypothalamic endocrinopathy.A 19-year-old man was referred for evaluation of polyuria and a goiter. He also had progressive exertional dyspnea and left axillary and right inguinal skin lesions.The thyroid was symmetrically enlarged, firm, and smooth, each lobe measuring 10 x 5 cm. There were several left axillary...References1. BRAUNSTEINKOHLER GP: Pituitary function in Hand-Schüller-Christian disease: evidence for deficient growth-hormone release in patients with short stature. N Engl J Med 286:1225-1229, 1972 CrossrefMedlineGoogle Scholar2. CLINEGOLDE MD: A review and reevaluation of the histiocytic disorders. Am J Med 55:49-60, 1973 CrossrefMedlineGoogle Scholar3. GATESFRIESENSAMAAN RHN: Inappropriate lactation and amenorrhea: pathological and diagnostic considerations. Acta Endocrinol 72:101-114, 1973 CrossrefMedlineGoogle Scholar4. HIRATASAKAMOTOYOSHIMOTOKATOMATSUKURAIMURA YNYYSH: Diabetes insipidus and galactorrhea caused by histiocytosis X. Endocrinol Jpn 22:311-318, 1975 CrossrefMedlineGoogle Scholar5. HASHIMOTOMIYAIUOZUMIMORIWATANABEKUMAHARA TKTSMY: Effect of prolonged LH-releasing hormone administration on gonadotropin response in patients with hypothalamic and pituitary tumors. J Clin Endocrinol Metab 41:712-716, 1975 CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: University of Pennsylvania School of Medicine Philadelphia, Pennsylvania PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited BySolitary Langerhans Histiocytosis of the Thyroid Gland: A Case Report and Literature ReviewPituitary Function in Systemic DisordersThyroid involvement in Langerhans cell histiocytosis: a report of two cases and review of the literatureLangerhans cell histiocytosis presenting as a thyroid gland massHistiocytose X pulmonaire et hypothalamo-hypophysaire, diagnostiquée par biopsie cérébrale stéréotaxiqueLangerhans Cell Histiocytosis of the Thyroid: A Report of Two Cases and Review of the LiteratureAtypical dendritic cell–related histiocytosis with goiter and primary hypothyroidismInfiltrative Diseases of the Pituitary GlandHistiocytosis X involving the thyroid and hypothalamus.Intrasellar mass with hypopituitarism as a manifestation of sarcoidosisHistiocytosis X of the thyroid masquerading as thyroid carcinomaHistiocytosis X: Sequential Involvement of Thirst and Antidiuretic Hormone CentresRadiation therapy in soft-tissue lesions in histiocytosis X (Langerhans' cell histiocytosis)Histiocytosis-X of the hypothalamus: Case report and literature reviewDiabetes InsipidusThyroid localization in adult histiocytosis XHistiozytosis XProlactin and Growth Hormone in Health and DiseaseClinicopathologic ConferenceThe Hypothalamus: Physiology and PathophysiologyHeadaches, impaired mentation, diabetes insipidus and exophthalmosis in a 50 year old manThe Histiocytic Disorders: A Pathophysiologic AnalysisJEROME E. GROOPMAN, M.D., DAVID W. GOLDE, M.D. 1 April 1978Volume 88, Issue 4Page: 512-513KeywordsBiopsyDyspneaFollicle stimulating hormoneHistiocytesLesionsMedical servicesProlactinThyroidThyroid-stimulating hormone Issue Published: 1 April 1978 PDF DownloadLoading ...