tbuckley/cabot-search huggingface dataset:
Abstract 869: Body mass index, weight gain, and physical activity during adulthood in relation to colorectal cancer risk
Authors: Huakang Tu, Xia Pu, Carrie Daniel-MacDougall, Stephanie C. Melkonian, Yuanqing Ye, Gottumukkala S. Raju, Scott Kopetz, Xifeng Wu
Journal: Cancer Research (2015)

Abstract Background: The impact of obesity/overweight, weight gain, and physical activity during adulthood on colorectal cancer (CRC) risk is not clear. To examine the associations between body mass index (BMI), weight gain, and physical activity during adulthood and CRC risk, we conducted a case-control study of incident CRC. Methods: Incident CRC case subjects were recruited from the University of Texas MD Anderson Cancer Center in Houston, Texas; healthy control subjects without a history of cancer, except non-melanoma skin cancer, were identified and recruited using random digit dialing. Epidemiologic data were collected by in-person interview. Unconditional logistic regression and regression spline were performed to obtain odds ratios (ORs). All statistical tests were two-sided. Results: A total of 524 non-Hispanic white case subjects and 1,053 healthy control subjects who were 40 years or older were included. In multivariate analysis, obesity (BMI ≥ 30) and overweight (BMI between 25 and 30) at age 20 years were significantly associated with a 2.4-fold (OR = 2.39, 95% confidence interval [CI] = 1.38 - 4.13, P = .002) and 1.6-fold (OR = 1.60, 95% CI = 1.19 - 2.14, P = .002) increased risk of CRC, respectively. Similarly, obesity and overweight at age 40 years were each significantly associated with a 2.1-fold (OR = 2.11, 95% CI = 1.49 - 2.99, P &amp;lt; .0001) and 1.7-fold (OR = 1.74, 95% CI = 1.32 - 2.30, P &amp;lt; .0001) increased risk of CRC. In addition, moderate and massive weight gain from age 20 to 40 years were associated with increased CRC risks, although this increase did not reach statistical significance. Moderate physical activity was significantly associated with a reduced risk of CRC (OR = 0.60, 95% CI = 0.44 - 0.81, P = .001). Conclusions: Obesity/overweight and physical activity during adulthood may influence susceptibility to CRC; also, our data suggest that weight gain during childhood and adolescence may play a more important role than weight gain during adulthood in CRC development. Citation Format: Huakang Tu, Xia Pu, Carrie Daniel-MacDougall, Stephanie C. Melkonian, Yuanqing Ye, Gottumukkala S. Raju, Scott Kopetz, Xifeng Wu. Body mass index, weight gain, and physical activity during adulthood in relation to colorectal cancer risk. [abstract]. In: Proceedings of the 106th Annual Meeting of the American Association for Cancer Research; 2015 Apr 18-22; Philadelphia, PA. Philadelphia (PA): AACR; Cancer Res 2015;75(15 Suppl):Abstract nr 869. doi:10.1158/1538-7445.AM2015-869
Complications of Descemet's Stripping with Automated Endothelial Keratoplasty
Authors: Leejee H. Suh, Sonia H. Yoo, Avnish Deobhakta, Kendall E. Donaldson, Eduardo C. Alfonso, William W. Culbertson, Terrence P. O'Brien
Journal: Ophthalmology (2008)
Valve-Related Hemodynamics Mediate Human Bicuspid Aortopathy
Authors: David G. Guzzardi, Alex J. Barker, Pim van Ooij, S. Chris Malaisrie, Jyothy J. Puthumana, Darrell D. Belke, Holly E.M. Mewhort, Daniyil A. Svystonyuk, Sean Kang, Subodh Verma, Jeremy Collins, James Carr, Robert O. Bonow, Michael Markl, James D. Thomas, Patrick M. McCarthy, Paul W.M. Fedak
Journal: Journal of the American College of Cardiology (2015)
Moderate drinking may help women with type 2 diabetes, says study.
Authors: Deborah Josefson
Journal: BMJ (2002)

Moderate alcohol intake may help control blood sugar in postmenopausal women with type 2 diabetes and may prevent the development of the disease and its cardiovascular sequelae in women at risk, a new report says . 

Researchers from the US Department of Agriculture's Beltsville Human Nutrition Research Center in Beltsville, Maryland, decided to study the effect of alcohol intake in postmenopausal women because alcohol has hypoglycaemic effects and the postmenopausal state is associated with an increased prevalence of insulin resistance, with resultant relative hyperglycaemia.

The investigators, led by Dr Michael Davies and Dr Philip Taylor, recruited 102 postmenopausal women in a randomised, crossover study that compared the effects of 0, 15, or 30 grams per day of alcohol on fasting insulin, triglyceride, and blood glucose concentrations and insulin sensitivity.

The researchers found that women who consumed 30 g/day, equivalent to just under four units a day, reduced their fasting insulin concentrations by 19% (P=0.004) and their triglyceride concentrations by 10% (P=0.001), compared with when they were in the 0 g/day arm. Despite the reduction in fasting insulin concentrations, blood glucose concentrations were maintained.

This translated into an improvement of insulin sensitivity of 7% Responses did not differ significantly between normal weight, overweight, and obese women.
Abstract 16402: Feasibility and Safety of Uninterrupted Rivaroxaban in Patients Undergoing Radiofrequency Ablation for Long Standing Persistent Atrial Fibrillation
Authors: Luigi Di Biase, Chintan Trivedi, Prasant Mohanty, Sanghamitra Mohanty, Rong Bai, Pasquale Santangeli, Javier Sanchez, Rodney Horton, G. Joseph Gallinghouse, Jason Zagrodzky, Steven Hao, Richard Hongo, Salwa Beheiry, Dhanujaya R. Lakkireddy, Madhu Reddy, Juan F. Viles-Gonzalez, J. David Burkhardt, Andrea Natale
Journal: Circulation (2014)

Introduction: Periprocedural anticoagulation management is key to minimize bleeding and thromboembolic complications during and after radiofrequency catheter ablation. Uninterrupted strategies with warfarin in high risk patients have shown superiority over interrupted strategies. We sought to assess the safety and feasibility uninterrupted rivaroxaban during atrial fibrillation (AF) ablation in patients with long standing persistent atrial fibrillation. Methods: One hundred and ninety six (196) consecutive patients undergoing AF ablation with uninterrupted rivaroxaban (last dose taken with food the night before the procedure and the following dose taken the night of the procedure) were matched by age and sex with an equal number of patients undergoing AF ablation with uninterrupted warfarin on a “therapeutic range”. All patients underwent pulmonary vein antrum isolation and ablation of non pulmonary vein triggers as disclosed by isoproterenol challenge test. Results: Baseline characteristics and procedural variables were similar between groups. Mean INR in warfarin group was 2.2 ± 0.5. CHADS2 Score was ≥ 2 in 141 (72%) in the rivaroxaban group and 130 (66%) in the warfarin patients (p=0.20). One pericardial tamponade and one groin hematoma occurred in rivaroxaban group while 2 patients in warfarin group developed groin hematoma. One TIA with positive MRI was present in the rivaroxaban group. Conclusions: Uninterrupted rivaroxaban therapy appears to be as safe and efficacious as uninterrupted warfarin strategy in preventing bleeding and thromboembolic events in patients undergoing long standing persistent AF ablation.
Abstract 15780: Duplication of the Conduction System in Heterotaxy Syndrome Delineated Using Remote Magnetic Navigation and Three-Dimensional Mapping
Authors: Irina Suman-Horduna, Akiko Ueda, Lilian Mantziari, Sonya V Babu-Narayan, Konstantinos Dimopoulos, Michael A Gatzoulis, Michael L Rigby, Siew Yen Ho, Sabine Ernst
Journal: Circulation (2012)

Introduction We investigated the presence of duplicated conduction systems in post-surgical adults with heterotaxy syndrome/atrial isomerism using remote magnetic navigation and 3D electro-anatomic...
Abstract 19983: Elevated Levels of Serum Cystatin C Predict Early Stage of Coronary Atherosclerotic Plaque Detected by Multidetector Computed Tomography
Authors: Atsuko Imai, Sei Komatsu, Tomoki Ohara, Teruaki Kamata, Jyunichi Yoshida, Mai Yoneda, Kouichi Nishiuchi, Jyunji Nakagawa, Kazuaki Miyaji, Yoshinobu Shimizu, Mitsuhiko Takewa, Kazuhisa Kodama
Journal: Circulation (2010)
Rapid and sensitive analysis of melatonin by LC-MS/MS and its application to pharmacokinetic study in dogs
Authors: Huimin Zhao, Yifei Wang, Yi Jin, Shu Liu, Haiyan Xu, Xiumei Lu
Journal: Asian Journal of Pharmaceutical Sciences (2015)

A rapid and sensitive liquid chromatography tandem mass spectrometry method was established and validated for determination of melatonin in dog plasma using desvenlafaxine as an internal standard (IS). Plasma samples were pretreated by liquid–liquid extraction with ethyl acetate. Chromatographic separation was carried out on a C18 column at a flow rate of 0.2 ml/min by an isocratic mobile phase of methanol : 5 mM ammonium acetate : formic acid (40:60:0.1, v/v/v). Positive ion mode detection was performed using multiple reaction monitoring (MRM) at m/z 233.2→174.2 for melatonin and m/z 264.2→58.2 for desvenlafaxine. The method was linear in the concentration range of 0.020–10 ng/ml with a correlation coefficient ≥0.996. The intra- and inter-assay precision (%RSD) values were within 12.6% (LLOQ 15.2%), and accuracy (%RE) ranged from −1.8% to 5.0% (LLOQ ±16.5%). The total analysis time was 3.0 min. The method was fully validated and successfully applied to a pharmacokinetic study of melatonin prolonged-release tablet in Beagle dogs. The values of half-life and Tmax were similar to the corresponding data reported before.
Increased Need for Right Ventricular Support in Patients With Chemotherapy-Induced Cardiomyopathy Undergoing Mechanical Circulatory Support
Authors: Guilherme H Oliveira, Matthias Dupont, David Naftel, Susan L Myers, Ya Yuan, W H Wilson Tang, Gonzalo Gonzalez-Stawinski, James B Young, David O Taylor, Randall C Starling
Journal: Journal of the American College of Cardiology (2013)
The National Cancer Institute
Authors: 石欣, 龚侃, 王少为, 宋玉琴, 徐岩英, 董尔丹
Journal: New England Journal of Medicine (1939)

美国国家癌症研究所(National Cancer Institute，NCI)成立于1937年，是国立卫生研究院(National Institutes of Health，NIH)历史最为悠久的研究所，也是美国癌症研究和资助的主要机构。通过立法及增加对癌症研究的投入，NCI在癌症研究领域取得一些成绩，使肺癌、结直肠癌、乳腺癌及前列腺癌的死亡率持续下降，另在胰腺癌、卵巢癌、白血病和甲状腺癌等肿瘤的诊断和治疗方面也取得了巨大成就。新近NCI制定了到20l5年的奋斗目标：“消除痛苦、减少死亡”，并将主要策略由“寻找进而破坏(seekanddestory)”转为“锁定并且控制(target and control)”。为了实现上述目标，NCI提出必须加强基础研究，以利癌症的早期发现(discovery)；以此为基础，将实验室的研究结果尽快用于临床，促进各种治疗措施的发展(development)；加强癌症防治的公共卫生宣传，以利于健康资讯的发布(delivery)。本文将简述NCI的历史沿革、主要目标、组织结构、资金预算以及所取得的成就。
Case 45-1990
Authors: Richard C. Cabot, Robert E. Scully, Eugene J. Mark, William F. McNeely, Betty U. McNeely, G.R. Epler, E.J. Mark
Journal: New England Journal of Medicine (1990)

Presentation of CaseA 68-year-old man was admitted to the hospital because of recurrent hemoptysis.There was a history of hemoptysis 30 years earlier, followed by resection of a hamartoma of the right upper lobe. Twenty-five years before admission an x-ray film of the chest was said to show evidence of pulmonary tuberculosis. Isoniazid and aminosalicylic acid were given for a "few weeks"; no further details were available.The patient was then well until four years before entry, when he began to have bouts of "bronchitis" with bronchospasm and hemoptysis each winter. The episodes became worse during each successive winter, . . .
Aberrant DNA Methylation Characterizes a Subtype of Juvenile Myelomonocytic Leukemia (JMML) with Poor Outcome.
Authors: Christiane Batz, Inga Sandrock, Peter Nöllke, Brigitte Strahm, Henrik Hasle, Marco Zecca, Jan Starý, Eva Bergsträsser, Barbara De Moerloose, Monika Trebo, Marry M. van den Heuvel, Dorota Wojcik, Franco Locatelli, Charlotte M Niemeyer, Christian Flotho
Journal: Blood (2009)
Abstract 17094: “Trojan Horse” Monocytes: a New Approach for Gene Delivery to Angioplastied Arteries
Authors: Ilia Fishbein, Richard F Adamo, Ricardo Corrales, Michael Chorny, Scott Forbes, Robert J Levy
Journal: Circulation (2011)

Introduction: Monocyte-derived macrophages are implicated in sustained inflammation typical of atherosclerotic and restenotic arteries. Since the role of macrophage-mediated inflammatory reactions in the progression of atherosclerosis and post-angioplasty restenosis is firmly established, multiple approaches have been devised to decrease the number and/or functionality of mononuclear phagocytic cells residing in atherosclerotic and stented arteries. However, no prior research has exploited the capability of monocytes to target sites of vascular injury in order to introduce pro-healing “therapeutic” genes into diseased vasculature. Here we report preliminary results demonstrating feasibility of this concept. Methods and Results: Monocytes were isolated from heparinized rat blood by sequential Ficoll and Percoll gradient centrifugation. The cells labeled with CM-DiI dye (5x10 5 cells/ml) were suspended in complete RPMI1640 medium and administered via tail vein to rats that underwent balloon denudation injury of carotid arteries 4 days prior to cell therapy. The animals were euthanized on day 8 after balloon injury (day 4 after monocyte delivery). The CM-DiI-labeled cells were found in the nascent neointima and adventitia of balloon-injured arteries (373±90 and 77±37 per mm 2 of tissue, respectively). Comparison of CM-DiI labeling with immunohistochemical staining results (CD 68) has demonstrated that up to 30% of all macrophages in the neointimal tissue of rats treated with ex vivo modified monocytes derive from the delivered cells. To verify functional competence of delivered cells, monocytes isolated as above were transduced with adenovectors driving synthesis of firefly luciferase and administered to rats that underwent Fogarty balloon injury 4 days prior to the cell delivery. One day later, luciferase expression in balloon injured arteries was confirmed by bioluminescence imaging. Conclusions: These pilot studies demonstrate the feasibility of using ex vivo transfected autologous or syngeneic monocytes as a means to introduce prohealing factors to diseased vasculature.
Improvements in Left Ventricular Hypertrophy and Diastolic Function Following Renal Denervation
Authors: Stephan H. Schirmer, Marwa M.Y.A. Sayed, Jan-Christian Reil, Christian Ukena, Dominik Linz, Michael Kindermann, Ulrich Laufs, Felix Mahfoud, Michael Böhm
Journal: Journal of the American College of Cardiology (2013)
Influence of Coronary Calcification on the Diagnostic Performance of CT Angiography Derived FFR in Coronary Artery Disease
Authors: Bjarne L. Nørgaard, Sara Gaur, Jonathon Leipsic, Hiroshi Ito, Toru Miyoshi, Seung-Jung Park, Ligita Zvaigzne, Nikolaos Tzemos, Jesper M. Jensen, Nicolaj Hansson, Brian Ko, Hiram Bezerra, Evald H. Christiansen, Anne Kaltoft, Jens F. Lassen, Hans Erik Bøtker, Stephan Achenbach
Journal: JACC. Cardiovascular imaging (2015)
Abstract 729: A More Accurate Method for Automatic Segmentation of Left Ventricular Mass by SPECT
Authors: Helen Soneson, Joey Ubachs, Martin Ugander, Håkan Arheden, Einar Heiberg
Journal: Circulation (2008)

Background: Accurate quantification of left ventricular mass (LVM) by single photon emission computed tomography (SPECT) is important when analysing LVM as such, but also when estimating the relative size of a perfusion defect. Existing algorithms for segmentation of LVM by SPECT have undergone limited validation. The aim of this study was to develop and validate a new segmentation algorithm for LVM by SPECT, and compare the new method to the commercially available software Quantitative Gated SPECT (QGS). Methods: 98 patients with known or suspected coronary artery disease underwent both rest and stress SPECT and MR. The new method was trained in 20 patients (40 studies) and tested in 78 patients (156 studies) by comparing LVM in both rest and stress SPECT with manually segmented LVM by magnetic resonance imaging (MRI) as the reference standard. The new method was compared to results from QGS. Results: The mean difference ±SD in LVM between SPECT and MRI was lower for the new method (6±15 %LVM) compared to QGS (18±19 %LVM) for both mean difference (p&lt;0.001, t test) and SD (p=0.01, F test), see Figure . Conclusion: The new method quantifies LVM with a significantly lower bias and variability compared to the commercially available QGS software, when compared to manually segmented LVM by MRI.
Abstract 3392: Ex vivo analysis of RAD51 foci induction in fresh tumor tissue: a promising new tool for the identification of homologous recombination-deficient tumors
Authors: Maaike Vreeswijk, M. Meijers, K.A.T. Naipal, N.S. Verkaik, R. Kanaar, J.H.J. Hoeijmakers, A. Jager, D.C. van Gent, K.N. Gaarenstroom, V.T.H.B.M. Smit, H. Vrieling
Journal: Cancer Research (2015)

Abstract Purpose. BRCA1 and BRCA2 related breast and ovarian tumors respond very well to treatment with PARP inhibitors (PARPi) because of their deficiency in homologous recombination (HR). We have indications that a substantial number of ovarian tumors might have deficiencies in HR unrelated to germline mutations in BRCA1 or BRCA2. A functional assay to assess HR efficacy might therefore allow identification of additional ovarian cancer patients that could benefit from PARPi treatment. Experimental procedure. Unselected fresh ovarian tumor samples were collected from patients undergoing surgery or ascites/pleural fluid drainage. Samples were irradiated with ionizing radiation ex vivo, fixed after 2 hours and embedded in paraffin. Sections were stained with hematoxylin and eosin and examined by pathologist. The presence of RAD51 foci in replicating cells as visualized by immunofluorescence was used as a functional read out for HR proficiency. Results. We determined the ability to induce RAD51 foci following radiation in ex vivo cultured ovarian tumor samples that contained sufficient numbers of replicating cells (n = 13). RAD51 foci formation was absent (&amp;lt;20% replicating cells showed RAD51 foci) in 46% of the samples. In one tumor sample that did not form RAD51 foci in replicating cells upon ionizing radiation, a pathogenic mutation in BRCA1 was identified (c.5277+1G&amp;gt;A). Genetic and epigenetic analyses of the other samples are ongoing. Conclusion. The ex vivo analysis of RAD51 foci induction in fresh tumor tissue is a promising new tool to identify HR deficient tumors. Not only is it an important time saving strategy compared to BRCA1/BRCA2 mutation analysis, it may also identify a much broader patient population that will be eligible for the treatment with PARP inhibitors. Citation Format: Maaike Vreeswijk, M. Meijers, K.A.T. Naipal, N.S. Verkaik, R. Kanaar, J.H.J. Hoeijmakers, A. Jager, D.C. van Gent, K.N. Gaarenstroom, V.T.H.B.M. Smit, H. Vrieling. Ex vivo analysis of RAD51 foci induction in fresh tumor tissue: a promising new tool for the identification of homologous recombination-deficient tumors. [abstract]. In: Proceedings of the 106th Annual Meeting of the American Association for Cancer Research; 2015 Apr 18-22; Philadelphia, PA. Philadelphia (PA): AACR; Cancer Res 2015;75(15 Suppl):Abstract nr 3392. doi:10.1158/1538-7445.AM2015-3392
Hydroxocobalamin. I. Blood Levels and Urinary Excretion of Vitamin B12 in Man After a Single Parenteral Dose of Aqueous Hydroxocobalamin, Aqueous Cyanocobalamin and Cyanocobalamin Zinc-Tannate Complex
Authors: GEORGE B. JERZY GLASS, HELEN R. SKEGGS, DUK HO LEE, E. LINN JONES, WILLIAM W. HARDY
Journal: Blood (1961)
Severe Ulceration of the Stomach after Endoscopic Injection Sclerotherapy
Authors: M. Inamori, J. Togawa, H. Kawamura, Y. Abe, H. Naitoh, H. Nagase, A. Nakajima, T. Saito, S. Tominaga, N. Ueno, K. Tanaka, H. Sekihara
Journal: Endoscopy (2003)

Endoscopic injection sclerotherapy (EIS) is a major therapeutic modality for the treatment of patients with bleeding from ruptured esophageal varices [1]. In addition, it has been demonstrated that prophylactic sclerotherapy in cirrhotic patients with known varices can reduce the rate of subsequent bleeding and improve survival [2]. The complications of endoscopic sclerotherapy include, for example, esophageal ulceration and esophageal perforation [3]. However, few reports have focused on the development of gastric ulcers following sclerotherapy [4].
Brentuximab Vedotin Administered To Platinum-Refractory Transplant Naïve Hodgkin Lymphoma Patients Can Increase The Proportion Achieving FDG-PET Negative Status
Authors: Maika Onishi, Leona Holmberg, Andrei R. Shustov, Karen Schiavo, Arnp Arnp, Mary Philip, Edward N. Libby, Ryan D. Cassaday, John M. Pagel, David G. Maloney, Damian J. Green, Brian G. Till, Oliver W. Press, Ajay K. Gopal
Journal: Blood (2013)
Abstract 17366: Reduced Protein O-GlcNAcylation Exacerbates Pressure Overload Induced Ventricular Dysfunction
Authors: Robert E Brainard, Steven P Jones
Journal: Circulation (2011)

Background: Hypertension is a leading risk factor for heart disease. Because the beta-O-linkage of N-acetylglucosamine (O-GlcNAc) post-translational modification plays a significant, pro-adaptive role in the cardiovascular system's response to various stressors, we hypothesized that this stress response (protein O-GlcNAcylation) was important in mitigating pressure overload-induced cardiac dysfunction. Methods and Results: Wild-type mice were randomly assigned to drug or vehicle groups and followed for seven days after transverse aortic constriction (TAC, i.e., pressure overload). The drug group was given TT04 (10mg/kg, bid), a specific inhibitor of O-GlcNAc transferase (the enzyme that adds O-GlcNAc to proteins). TT04 treatment significantly exacerbated systolic dysfunction (Fig 1B) despite no change in diastolic diameter (Fig 1A). TT04 treatment also diminished ejection fraction (Fig 1C) and reduced levels of protein O-GlcNAcylation (Fig 1D) compared to vehicle (p&lt;0.05). Conclusions: O-GlcNAc signaling plays an important, seemingly pro-adaptive role in the heart during pressure overload-induced cardiac dysfunction.
Serotnin as a possible biomarker in obstructive sleep apnea
Authors: Melissa C. Lipford, Kannan Ramar, Yao-Jen Liang, Chii-Wann Lin, Yun-Ting Chao, Jen An, Chih-Hsien Chiu, Yi-Ju Tsai, Chih-Hung Shu, Fei-Peng Lee, Rayleigh Ping-Ying Chiang
Journal: Sleep Medicine Reviews (2015)