tbuckley/cabot-search huggingface dataset:
Abstract P210: Lipoprotein Profiles in Patients With and Without Psoriasis
Authors: Paulo A Lotufo, Steven Jones, Michael Blaha, Cid Sabbag, Raul Dias-Santos, Peter P Toth, Isabela M Bensenor
Journal: Circulation (2015)

Introduction: Psoriasis is associated with chronically heightened systemic inflammatory tone and increased risk for cardiovascular disease. It remains to be established if the psoriatic state itself associates with dyslipidemia. Hypothesis: The lipid profile of patients with psoriasis is more atherogenic compared to disease-free control patients. Methods: The concentration and size of lipoprotein particles were measured using nuclear magnetic resonance spectroscopy in 221 patients with a diagnosis of psoriasis (53.6% men; mean age=56.6 years; mild cases=31%; moderate/severe only skin=27%; arthritis=27%)) and 689 disease-free persons matched by sex and age. We compared means of lipoprotein particle concentration and size using a univariate general linear model and adjusting for body-mass index, waist circumference, diabetes, use of lipid lowering-drugs, as well as duration/severity of psoriasis. Results: Patients with psoriasis were more overweight, had larger waist circumference, and a higher frequency of diabetes and use of lipid-lowering drugs. Total LDL particle means (nmol/L) for the psoriasis and control groups were 1436 (1378-1494) vs. 1420 (1388-1452) (P=0.4), respectively. The mean concentration of IDL was higher in patients with psoriasis compared to controls: 143.6 (130.7-156.5) vs. 106.1 (99.1-113.2), P&lt;0.01. Large and small LDL particle concentrations were similar between groups. Large VLDL/chylomicron particle concentrations (nmol/L) were higher in psoriasis patients compared to controls 6.1 (5.2-7.0) vs. 4.0 (3.6-4.5) (P&lt;0.01). Total HDL particle and subfractions were not statistically different between groups. The mean size (nm) of VLDL was higher in psoriasis patients: 50.2 (49.2-51.2) vs. 46.2 (45.6-46.7) (P&lt;0.001) for psoriasis and controls, respectively. In contrast, mean sizes of LDL and HDL particles were similar (P=0.3). Adjustment for covariates above mentioned did not change these findings. The absence/presence of arthritis did not change the results. Conclusion: Patients with psoriasis have a more atherogenic lipid profile compared to controls with higher levels of IDL and VLDL of large and small size. In addition, the greater mean size of VLDL particles in psoriasis compared to controls suggests enhanced secretion of triglyceride loaded VLDL, impaired lipolysis and impaired clearance of remnant IDL.
Subclinical hypothyroidism: a modifiable risk factor for depression?
Authors: J J Haggerty, R A Stern, G A Mason, J Beckwith, C E Morey, A J Prange
Journal: American Journal of Psychiatry (1993)

The authors assessed the lifetime history of major depression in 16 subjects with subclinical hypothyroidism and 15 subjects whose thyroid function was completely normal. The lifetime frequency of depression was significantly higher in the subjects who met the criteria for subclinical hypothyroidism (56%) than in those who did not (20%), suggesting that subclinical hypothyroidism may lower the threshold for the occurrence of depression.
Perlecan, the major proteoglycan of basement membranes, is altered in patients with Schwartz-Jampel syndrome (chondrodystrophic myotonia)
Authors: Sophie Nicole, Claire-Sophie Davoine, Haluk Topaloglu, Laurence Cattolico, Duarte Barral, Peter Beighton, Christiane Ben Hamida, Hadi Hammouda, Corinne Cruaud, Peter S. White, Delphine Samson, J. Andoni Urtizberea, Franck Lehmann-Horn, Jean Weissenbach, Faycal Hentati, Bertrand Fontaine
Journal: Nature Genetics (2000)
Abstract MP67: Objectively Measured Sleep Characteristics and Prevalence of Coronary Artery Calcification: The Multi-Ethnic Study of Atherosclerosis Sleep Study
Authors: Pamela L Lutsey, Robyn L McClelland, Daniel Duprez, Steven Shea, Eyal Shahar, Mako Nagayoshi, Matthew Budoff, Joel D Kaufman, Susan Redline
Journal: Circulation (2015)

Background:  It is unclear whether objectively measured obstructive sleep apnea (OSA) and other abnormal sleep phenotypes are associated with coronary artery calcification (CAC) prevalence independent of obesity, a classic confounder. We tested that hypothesis, and also examined possible mediation by cardiovascular risk factors.   Methods:  A total of 1,465 Multi-Ethnic Study of Atherosclerosis participants [mean age 68 years] had both coronary CT and in-home polysomnography and actigraphy. OSA categories were defined by apnea-hypopnea index (AHI). Other sleep phenotypes included measures of sleep stages, fragmentation and duration. Prevalence ratios for CAC >0 and >400 (high burden) were calculated.   Results:  Participants with severe OSA (AHI ≥30; 14.6%) were more likely to have prevalent CAC, relative to those with no evidence of OSA, after adjustment for demographics and smoking status [1.16 (95% CI: 1.06-1.26)], body mass index [1.11 (1.02-1.21)], and traditional cardiovascular risk factors [1.10 (1.01-1.19)]. Other markers of hypoxia tended to be associated with higher prevalence of CAC >0, while markers of sleep architecture, fragmentation and duration were not. For CAC >400 a higher prevalence was observed with both a higher arousal index and less slow-wave sleep. Overall, associations were somewhat stronger among younger participants, but there was no evidence of interaction by sex or race/ethnicity.   Conclusions:  Subclinical coronary artery disease, measured by CAC >0, was more prevalent among participants with OSA, independent of obesity and traditional cardiovascular risk factors, relative to participants with no OSA. These findings support recent evidence suggesting that OSA is associated with risk of incident coronary artery disease.
LSC 2013 abstract - The role of glutaredoxin-1 in diesel exhaust particles-induced pulmonary inflammation
Authors: Sharen Provoost, Katrien De Grove, Ken Bracke, Guy Brusselle, Guy Joos, Tania Maes, Niki Reynaert
Journal: European Respiratory Journal (2013)

Rationale:  Inhalation of diesel exhaust particles (DEP) is associated with an oxidative and inflammatory response in the lung (Provoost et al., J Allergy Clin Immunol., 2012, 129: 483-491). Glutaredoxin-1 (GRX1) is a cytosolic enzyme that can regulate redox-dependent signalling cascades and pro-inflammatory transcription factors via modulation of protein glutathionylation. We investigated whether GRX1 regulates DEP-induced pulmonary inflammation.   Methods:  WT and GRX1 knockout (KO) mice were intratracheally instilled with saline or 100 µg DEP (SRM 2975). Inflammatory cell recruitment towards the bronchoalveolar lavage fluid (BALF) and lung tissue were examined by flow cytometry.   Results:  WT mice showed increased neutrophil recruitment towards BALF in response to DEP exposure, which was augmented in GRX1 KO mice. The recruitment of monocytes and dendritic cells to BALF was similar between DEP-exposed WT and GRX1 KO mice. In lung tissue, DEP-induced inflammation was comparable between WT and GRX1 KO.   Conclusion:  GRX1 has a limited, but protective role in DEP-induced neutrophilic inflammation.   Funding:  Fund for Scientific Research Flanders - Belgium (FWO Vlaanderen; Research Project G.0329.11N), Interuniversity Attraction Poles (IUAP) - Belgian Science Policy P6/35 and P7/30 and Concerted Research Initiative of the Ghent University, Project No BOF/GOA 01G01009.
The Principles and Practice of Ultrasonography in Obstetrics and Gynecology
Authors: James D. Bowie
Journal: JAMA (1981)

This multiauthored text is an outstanding review of diagnostic ultrasonography in the field of obstetrics and gynecology. Ultrasonographers and obstetricians who are involved in these ultrasound applications will wish to review the book carefully. With the much improved second edition,<i>The Principles and Practice of Ultrasonography in Obstetrics and Gynecology</i>will become a standard reference for obstetric and gynecologic ultrasound. As is frequently true with multiauthored texts, there are some strong chapters and some done less well. Among the former, the chapters on normal female pelvis by W. Frederick Sample, embryology by A. Everette James et al, and postpartum ultrasound by Roger C. Sanders are outstanding reviews. A number of chapters are of interest only to a more limited number of readers, but add to the comprehensiveness of this book. These include chapters on Doppler ultrasound, fetal breathing, pelvimetry, and experimental sonofication of tissue. A new and important aspect of
Campaigns Against Ionizing Radiation and Changed Practice Patterns for Imaging Use in Pediatric Appendicitis
Authors: Morgan K. Richards, Meera Kotagal, Adam B. Goldin
Journal: JAMA Pediatrics (2015)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Pediatrics HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Pediatrics journal
Treatment of poor-prognosis, newly diagnosed acute myeloid leukemia with ara-C and recombinant human granulocyte-macrophage colony- stimulating factor
Authors: EH Estey, D Dixon, HM Kantarjian, MJ Keating, K McCredie, GP Bodey, R Kurzrock, M Talpaz, EJ Freireich, AB Deisseroth
Journal: Blood (1990)
Abstract 15062: Aortic Stiffness and ProBNP Are Increased at Term and 6 Months After Pre-Eclamptic Pregnancy
Authors: Mette-Elise Estensen, Espen Remme, Guro Grindheim, Abigail Swillens, Lars Gullestad, Otto A Smiseth, Tore Henriksen, Patrick Segers, Svend Aakhus
Journal: Circulation (2010)
HYSTERIA—SOME COMMON MISCONCEPTIONS
Authors: David Lester
Journal: Annals of Internal Medicine (1941)

Article1 January 1941HYSTERIA—SOME COMMON MISCONCEPTIONSDAVID LESTER, M.D.DAVID LESTER, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-14-7-1248 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptGreat strides have been made in recent years toward dissemination of psychiatric knowledge so that there now exists within the medical profession a generally wholesome attitude toward psychiatric illnesses. This is particularly true of the psychoses. There still exist, however, attitudes on the part of many members of the profession toward certain psychiatric problems which need dispelling. The attitude toward "hysteria" seems to be the worst. It is not at all unusual to see a physician, who has previously displayed an active interest in an illness and the utmost courtesy to the patient suffering therefrom, alter his attitude completely upon...Bibliography1. CRISPELL RS: Extramural and neuropsychiatry in a general hospital, South. Med. and Surg., 1940, cii, 105. Google Scholar2. SADLER WS: Theory and practice of psychiatry, p. 675, C. V. Mosby Co., St. Louis. Google Scholar3. Ibid: p. 671. Google Scholar4. Ibid: p. 666 and p. 669. Google Scholar5. Ibid: p. 662. Google Scholar6. HENDERSONGILLESPIE DKRD: A textbook of psychiatry, Fourth Edition, p. 450, Oxford University Press. Google Scholar7. Ibid: p. 459. Google Scholar8. ROSANOFF AJ: Manual of psychiatry, Seventh Edition, p. 1055, John Wiley & Sons, Inc. Google Scholar9. Ibid: p. 627. Google Scholar10. MENNINGER KA: The human mind, Second Edition, p. 383, Alfred A. Knopf. Google Scholar11. COBB S: Psychiatric approach to the treatment of epilepsy, Am. Jr. Psychiat., 1940, xcvi, 1009. CrossrefGoogle Scholar12. PIKER P: 1817 cases of suicidal attempt—a preliminary statistical survey, Am. Jr. Psychiat., 1938, xcv, 97. CrossrefGoogle Scholar13. NOYES AP: Modern clinical psychiatry, Second Edition, p. 343, W. B. Saunders & Co. Google Scholar14. BILLINGS EG: A handbook of elementary psychobiology and psychiatry, p. 120, Macmillan, New York. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: DAVID LESTER, M.D.Affiliations: Durham, North Carolina*Received for publication May 18, 1940.From the Department of Psychiatry, Duke Medical School, Durham, N. C. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 January 1941Volume 14, Issue 7 Page: 1248-1255 Keywords Psychoses ePublished: 1 December 2008 Issue Published: 1 January 1941 PDF downloadLoading ...
Abstract 108: A Physician Onboard the Advanced Life Support Unit Has a Clinical Impact on Outcome of Witnessed Patients With Out-of-Hospital Cardiac Arrest
Authors: Sunao Kojima, Kunihiko Matsui, Yoshihiko Seino, Hisao Ogawa, Naohiro Yonemoto, Hiroshi Nonogi, Takeshi Kimura, Ken Nagao, Japanese Circulation Society-Resuscitation ScienceStudy
Journal: Circulation (2010)
The oral corticosteroid sparing effect of omalizumab in patients with severe chronic asthma: Is there a difference when you become 12 years old?
Authors: Samantha Moss, Michael Mckean, David Spencer
Journal: European Respiratory Journal (2011)

Omalizumab is licensed for treatment of severe persistent allergic asthma over the age of 6 years. In England and Wales, the National Institute of Clinical Excellence recommends omalizumab as a possible treatment for young people over the age of 12, but not for children age 6 – 12.  We describe a population of children with severe asthma who have undergone a 16 week open label therapeutic trial of omalizumab.  The dose of oral corticosteroids at the start & end of the trial was documented. Some children completed modified quality of life and asthma symptom control questionnaires before and after the trial.  To date 15 children (13 boys) age 3-11 years, and 19 children (12 boys) age 11-16 years have completed a therapeutic trial in our centre. The baseline IgE was comparable between groups. We were able to reduce the daily corticosteroid dose in 13 children  12 years (median pre 10, post 5 mg, p 12 n=16), and asthma control ( 12 n= 15) in all bar 1 patient in each group.  In conclusion, the use of omalizumab in children with severe asthma may result in a clinically significant decrease in the use of oral corticosteroids and an improvement in quality of life and a reduction in asthma symptoms. In our practice omalizumab was as effective in children
Male Infertility: A Guide for the Clinician
Authors: Alan Trounson
Journal: BMJ (2001)

Anne M Jequier Blackwell Science, £79.50, pp 384, ISBN 0 632 0512 9

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As a result of the rapid development of in vitro fertilisation for treating both male and female infertility, male infertility has become just as important for a consultant gynaecologist assessing an infertile couple as it has for a specialist andrologist. Consequently, the detailed and intricate tests that consultant andrologists developed to identify the cause of …

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<i>Portrait of My Teacher, Fräulein Sophie von Prieser</i>
Authors: Jeanette M. Smith
Journal: JAMA (2015)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Schizophrenia susceptibility loci on chromosomes 13q32 and 8p21
Authors: Jean-Louis Blouin, Beth A. Dombroski, Swapan K. Nath, Virginia K. Lasseter, Paula S. Wolyniec, Gerald Nestadt, Mary Thornquist, Gail Ullrich, John McGrath, Laura Kasch, Malgorzata Lamacz, Marion G. Thomas, Corinne Gehrig, Uppala Radhakrishna, Sarah E. Snyder, Katherine G. Balk, Karin Neufeld, Karen L. Swartz, Nicola DeMarchi, George N. Papadimitriou, Dimitris G. Dikeos, Costas N. Stefanis, Aravinda Chakravarti, Barton Childs, David E. Housman, Haig H. Kazazian, Stylianos E. Antonarakis, Ann E. Pulver
Journal: Nature Genetics (1998)
Improvement Seen in US Immunization Rates
Authors: Mike Mitka
Journal: JAMA (2004)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Abstract 16922: Feasibility of Family Sodium Watcher Program to Improve Adherence to Low Sodium Diet in Patients with Heart Failure and Caregivers
Authors: Misook L Chung, Debra K Moser, Terry A Lennie
Journal: Circulation (2014)

Introduction: Poor adherence to the low sodium diet (LSD), common in patients with heart failure (HF), is a major predictor of hospitalization for exacerbation of HF. When family member’s consume the same LSD recommended for patients, patient adherence is increased. The Sodium Watcher Program (SWAP) was developed to improve adherence to LSD using a gradual adaptation strategy and an electronic salt monitoring device that allows detection of sodium content in food. The purpose of this study was to examine whether the SWAP was feasible and if it resulted in reduction in sodium intake for patients with HF and their caregivers. Method: In this 2-group randomized controlled trial, 15 patient-caregiver dyads completed 24-hour urine collection for sodium excretion level (24h UNa) at baseline and 3 months follow up. Dyads in the SWAP intervention (n=8) received 12 weeks of self-care education for HF and LSD with gradual adaptation strategies in salt intake via 2 home visits and 4 calls. Paired t-test was used to compare adherence to LSD at two data collection times. Only intervention group evaluated use of the electronic salt monitoring devices and the intervention program at 3 months. Results: The intervention group had a significant reduction in 24h UNa (Patients 3894mg vs. 3604mg, p=.02; caregivers 4123mg vs. 3380mg, p&lt;.05). They also reported significant increased level of enjoying eating LSD (M =5.4 on 10-point rating scale vs. M=7.9 p &lt;.01) and 90% noticed a change in their ability to taste salt in their food at the 3-month follow up. They reported that use of the electronic monitoring devices was easy (M=8.3 on 10-point rating scale) and helpful in supporting LSD adherence (M=8.8 on 10-point rating scale). Caregivers in the intervention reported no significant changes in burden levels. The usual care control group had no change in 24h UNa (patients 4369 mg vs. 4434 mg; caregivers 3301 mg vs. 4826mg). Conclusion: The findings demonstrated that the SWaP is feasible and efficacious for following LSD by dyads. The intervention was feasible for caregivers and did not increase caregiver burden. This family intervention may have potential for promoting long-term adherence and needs to be tested in a larger clinical trial.