tbuckley/cabot-search huggingface dataset:
Metal corrosion by chloride in sweat
Authors: J.L. BURTON, R.J. PYE, D.B. BROOKES
Journal: British Journal of Dermatology (1976)

Journal Article Metal corrosion by chloride in sweat: THE PROBLEM OF'RUSTERS' IN INDUSTRY Get access J.L. BURTON, J.L. BURTON Department of Dermatology, Bristol Royal Infirmary, Bristol BS2 8HW Reprint requests to Dr J.L.Burton, Bristol. Search for other works by this author on: Oxford Academic Google Scholar R.J. PYE, R.J. PYE Department of Dermatology, Bristol Royal Infirmary, Bristol BS2 8HW Search for other works by this author on: Oxford Academic Google Scholar D.B. BROOKES D.B. BROOKES Beaumont Hospital, Lancaster LA1 2JF Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 95, Issue 4, 1 October 1976, Pages 417–422, https://doi.org/10.1111/j.1365-2133.1976.tb00843.x Published: 01 October 1976
Abstract P439: Evaluating the Use of Motivational Interviewing in an Exercise Counseling Intervention
Authors: Margaret M McCarthy, Victoria V Dickson, Stuart D Katz, Deborah A Chyun
Journal: Circulation (2014)

Background: Exercise continues to be promoted for the primary and secondary prevention of heart disease, yet many adults remain inactive and ethnic minority adults are less active than Whites. One of the goals of Healthy People 2020 is to increase the proportion of office visits that include counseling about exercise with patients diagnosed with heart disease; one approach may be the use of motivational interviewing (MI). However, adherence to the essential principles of MI is critical in achieving desired outcomes. Purpose: The purpose of this study was to evaluate the use of MI in an exercise counseling intervention in a sample of minority adults with heart failure (HF). Methods: Twenty ethnic minority adults with stable HF were recruited from an urban HF clinic. Measures of physical activity (International Physical Activity Questionnaire (IPAQ); weekly step-counts via accelerometer) and functional status (Duke Activity Status Index (DASI); 6-minute walk test [6MWT]) were taken at baseline and 12-weeks. The initial exercise counseling session (15 minutes) using MI discussed previous exercise experience, future goals, and practical exercise guidelines, including symptom management. The interview guide, written using principles of MI, was reviewed with an expert in MI and revised prior to the first interview. During subject recruitment, four subjects’ interviews were reviewed (#3, #4, #16, #20) by another independent expert and scored for use of MI. After each scoring and discussion of results, the interview guide was again revised to further facilitate the use of MI. The initial session was followed by 12 weekly 5-minute phone calls. Results: Interview #3 scored 50% overall adherence to MI with more closed than open questions (6 vs.4) and 44% of reflections were complex (vs. simple). Interview #4 ranked 40% MI adherent with more closed vs. open questions (9 vs. 3) and only 30% complex reflections. Interview #16 ranked 100% adherent with more closed than open questions (6 vs. 3) but more complex reflections (54%). Interview #20 ranked 80% adherent with more open vs. closed questions (8 vs. 1) and 42% complex reflections. At 12 weeks, there were concurrent significant improvements in the IPAQ walking score (p=.04), weekly step-counts (p=.03), and 6MWT (p=.0006) with a trend toward significant improvement in the DASI (p=.08). Conclusion: The use of MI in brief exercise counseling and phone follow-up may lead to increases in physical activity and functional status. Independent scoring and repeated review of the practice of MI over time may improve its continued use. Further testing of the intervention in a randomized trial is warranted.
Abstract 12553: Telmisartan, a Clinically Available Anti-Hypertensive Medicine, Enhances Mitochondrial Function and Improves Endothelial Dysfunction Through the AMPK Pathway
Authors: Hirofumi Kurokawa, Seigo Sugiyama, Toshimitsu Nozaki, Koichi Sugamura, Kensuke Toyama, Junichi Matsubara, Koichiro Fujisue, Keisuke Ohba, Hirofumi Maeda, Eiichirou Yamamoto, Kenichi Tsujita, Koichi Kaikita, Seiji Hokimoto, Hisao Ogawa
Journal: Circulation (2014)

Background: Mitochondrial dysfunction plays an important role in cellular senescence and impaired function of vascular endothelium, resulted in cardiovascular diseases. AMP-activated protein kinase (AMPK) plays a critical role in mitochondrial biogenesis and endothelial function. Telmisartan (TELMI) is a unique angiotensin II type I receptor blocker (ARB) that has clinically been shown to prevent cardiovascular events in high risk patients. We investigated whether TELMI could modulate mitochondrial function leads to improvement of endothelial function via AMPK, and could improve endothelial function in mice and human. Methods and Results: In cultured human coronary artery endothelial cells (HCAECs), TELMI significantly increased the phosphorylation of AMPK (1.61±0.45 fold, p&lt;0.05) and endothelial nitric oxide synthase (eNOS) (1.39±0.23 fold, p&lt;0.01), and enhanced mitochondrial function as assessed by both mitochondrial reductase activity (1.22±0.15 fold, p&lt;0.01) and ATP production (1.16±0.93 fold, p&lt;0.05). TELMI prevented cellular senescence (senescence associated β-galactosidase staining assay: 0.61±0.14 fold, p&lt;0.01) and enhanced angiogenic activity (tubular formation: 1.73±0.25 fold, p&lt;0.01). These effects by TELMI were abolished by both pharmacological and genetical inhibition of AMPK. In a mouse model of metabolic syndrome, TELMI prevented high fat diet (HFD)-induced endothelial dysfunction, as shown by acetylcholine-induced vascular relaxation (HFD: 74.5±3.3%, HFD+TELMI: 84.8±3.2% P&lt;0.05), and increased the phosphorylation of AMPK (1.28±0.13 fold, P&lt;0.05) and eNOS (1.27±0.16 fold, P&lt;0.05) in aortas. In hypertensive patients, switching treatment from other ARB or angiotensin converting enzyme inhibitors to TELMI improved endothelial function assessed by reactive hyperemia on peripheral arterial tonometry index (pre-TELMI: 0.40±0.14, post-TELMI 0.54±0.17, p&lt;0.05). Conclusions: TELMI significantly enhanced mitochondrial function and exhibited anti-senescent activity via AMPK in HCAECs, and improved endothelial function in mice and human. The vascular protective effects induced by TELMI may partly be due to its enhancement of mitochondrial function and reduction of endothelial senescence by AMPK.
Ayak cerrahisi öncesi deri ve tırnağın hazırlanması: Dört farklı yöntemin bakteriyel yükün azaltılması bakımından etkinliğinin kıyaslanması
Authors: Ricardo Becerro de Bengoa Vallejo, Marta Elena Losa Iglesias, Luis Alou Cervera, David Sevillano Fernández, veJosé Prieto Prieto
Journal: Journal of the American Academy of Dermatology (2010)
Tenofovir, Equivalence, and Noninferiority
Authors: Jean-Jacques Parienti
Journal: JAMA (2004)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
PTEN is an inhibitor of prostate cancer cell migration in the bone microenvironment
Authors: Zhong Wu, Andrew Young, Dan Theodorescu
Journal: Cancer Research (2006)

3970  The tumor suppressor gene PTEN is frequently inactivated in advanced human prostate cancer but little is known about its role in prostate cancer bone metastasis. To explore the role of PTEN in this process, we have reconstituted PTEN expression in a PTEN-null bone metastatic human prostate cancer cell line, LnCaP C4-2, using the Tet-On inducible system. In the Boyden chamber motility assay, we found that C4-2 cells selectively migrated towards condition media from primary mouse calvaria compared to that derived from lung fibroblasts, suggesting that specific factor(s) presented in bone condition media stimulated cancer cell migration. Similar stimulation of cell migration was observed with condition media from an established mouse calvaria osteoblast cell line, MC3T3 clone 4. In contrast, condition media from the non osteoblast clone 24 of MC3T3 cells had less effect on cell migration (p=0.047). C4-2 growth rates were similar in primary calvaria condition media vs lung condition media indicating the difference of cell motility towards calvaria condition media vs lung condition media is not due to their effect on cell growth. Expression of PTEN inhibited the motility of C4-2 cells towards calvaria conditioned but not lung conditioned media and this inhibitory effect was dependent on its lipid phosphatase activity. Furthermore, similar expression levels of constitutively active Rac1 but not Cdc42 could partially abolish this inhibitory effect suggesting the inhibitory effect of PTEN is mediated in part by this small GTPase. In summary, our results provide evidence that bone specific factor(s) promotes prostate cancer cell migration and potentially implicate PTEN in prostate cancer bone metastasis.
Strategies in the Design of Small-Molecule Fluorescent Probes for Peptidases
Authors: Laizhong Chen, Jing Li, Lupei Du, Minyong Li
Journal: Medicinal Research Reviews (2014)

Abstract Peptidases, which can cleave specific peptide bonds in innumerable categories of substrates, usually present pivotal positions in protein activation, cell signaling and regulation as well as in the origination of amino acids for protein generation or application in other metabolic pathways. They are also involved in many pathological conditions, such as cancer, atherosclerosis, arthritis, and neurodegenerative disorders. This review article aims to conduct a wide‐ranging survey on the development of small‐molecule fluorescent probes for peptidases, as well as to realize the state of the art in the tailor‐made probes for diverse types of peptidases.
Welsh hospital recruits Filipino nurses
Authors: Roger Dobson
Journal: BMJ (1999)

A Welsh hospital which has recruited 18 Filipino nurses has encountered confrontation from nursing unions. Fifteen of the nurses arrived at Llandough Hospital in Cardiff this week as a result of a recruitment drive launched in the Philippines after attempts to get staff elsewhere had failed.

But both the Royal College of Nursing and UNISON are unhappy about the move and said that inadequate pay rises and unfavourable trust contracts are among the …
Diagnosis and treatment of primary CNS lymphoma in immunocompetent patients: guidelines from the European Association for Neuro-Oncology
Authors: Khê Hoang-Xuan, Eric Bessell, Jacoline Bromberg, Andreas F Hottinger, Matthias Preusser, Roberta Rudà, Uwe Schlegel, Tali Siegal, Carole Soussain, Ufuk Abacioglu, Nathalie Cassoux, Martina Deckert, Clemens M F Dirven, Andrés J M Ferreri, Francesc Graus, Roger Henriksson, Ulrich Herrlinger, Martin Taphoorn, Riccardo Soffietti, Michael Weller
Journal: The Lancet Oncology (2015)
Abstract 13256: Impact of Albuminuria on Contrast-induced Acute Kidney Injury and In-hospital Adverse Cardiac Events in Patients Who Underwent Emergency Coronary Intervention
Authors: Ayako Kunimura, Tadayuki Uetani, Takashi Kataoka, Masahiro Takeshita, Kazuhiro Harada, Satoshi Okumura, Norihiro Shinoda, Ken Harada, Bunichi Kato, Masataka Kato, Nobuyuki Marui, Michio Nanki, Tatsuaki Matsubara, Hideki Ishii, Tetsuya Amano, Toyoaki Murohara
Journal: Circulation (2014)

Purpose:  The aim of this study was to evaluate the predictive value of albuminuria for risk of contrast-induced acute kidney injury (CI-AKI) and in-hospital adverse events (AE) in patients with ACS who underwent emergency PCI.   Methods:  A total of 215 consecutive ACS patients undergoing emergency PCI were enrolled. Urinary albumin to creatinin ratio (ACR; mg/gCr) was measured and patients were divided into three groups as follows; normoalbuminuria (ACR    Results:  Incidence of CI-AKI (p   Conclusions:  The elevated urinary albumin excretion rate is an independent predictor of CI-AKI and in-hospital AE in patients with ACS and graded increase in the incidence across microalbuminuria to macroalbuminuria were observed.
Abstract 15493: Comparison of Myocardial Scar Indices for Patients Treated With Pre-Hospital Reduced Dose Fibrinolytic Followed by Percutaneous Coronary Intervention versus Percutaneous Coronary Intervention Alone for Treatment of ST-Elevation Myocardial Infarction
Authors: Amirreza Solhpour, Kay-Won Chang, Prakash Balan, Catalin Loghin, Stefano M Sdringola, Ali E Denktas, Ashley L Gunter, Daniel W Maland, Eugene Stautberg, H. Vernon Anderson, Richard W Smalling
Journal: Circulation (2014)

Introduction: Current standard treatment for ST-elevation myocardial infarction (STEMI) is primary percutaneous coronary intervention (PPCI). Early reperfusion results in shorter ischemic time (IT), smaller infarct size and lower mortality. Since fibrinolysis can be initiated earlier than PPCI; for over 7 years, we have used a strategy of field evaluation for STEMI using 12 lead ECGs transmitted by emergency services personnel with over-read by emergency center physicians. Appropriate patients receive pre-hospital reduced dose fibrinolytic (10 units reteplase) along with aspirin, clopidogrel, and heparin, and are transported for urgent PCI (FAST-PCI strategy).

Hypothesis: Patient with STEMI in FAST-PCI group have reduced myocardial scar and microvascular obstruction (MVO) indices measured by cardiac magnetic resonance (CMR) compared with those in PPCI.

Methods: Patients with CMR performed 3 to 5 days after STEMI at our tertiary center were prospectively included for retrospective analysis. Demographic, clinical, angiographic data and outcomes were compared. We defined IT as time from onset of pain to device activation. Patients were divided into groups based on IT (<120, 120-179, ≥ 180 minutes). Within each group, patients were compared by PPCI and FAST-PCI groups. The primary endpoints were myocardial scar and MVO indices as defined in the table.

Results: Between 1/2007 and 2/2014, we treated 1323 STEMI patients of which 357 (26.9%) had CMR after STEMI. FAST-PCI was employed in 216 (60.5%) and PPCI in 141 (39.5%) patients. The two treatment groups in each IT interval were well matched for age, cardiac risk factors, left main and left anterior descending artery infarct. Data are shown in the table.

Conclusions: For STEMI patients with IT < 3 hours, FAST-PCI had reduced myocardial scar and MVO indices compared to PPCI. However, for patients with IT ≤ 3 hours, there was no significant difference in those indices between the two treatment groups

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Conradi-Hünermann-Happle syndrome in males vs. MEND syndrome (male EBP disorder with neurological defects)
Authors: A.W. Arnold, L. Bruckner-Tuderman, C. Has, R. Happle
Journal: British Journal of Dermatology (2012)

There is confusion in the literature concerning disorders caused by EBP (emopamil-binding protein) mutations in males.To study the clinical and genetic differences in males affected either with Conradi-Hünermann-Happle (CHH) syndrome (X-linked dominant chondrodysplasia punctata, CDPX2) or with a nonmosaic, X-linked recessive disorder for which we propose the acronymic term MEND syndrome (male EBP disorder with neurological defects).We report a 7-year-old boy with a history of transient scaly erythematous lesions on his limbs, trunk and scalp soon after birth. DNA was isolated from ethylenediamine tetraacetic acid-blood samples of the patient and the four coding exons of the EBP gene were amplified by polymerase chain reaction. We review all published cases of CHH syndrome in males in the literature and elaborate the clinical and genetic differences between CHH syndrome in males and MEND syndrome.We found at position 33 of the EBP gene the variant c.33C>A leading to the same nonsense mutation p.Y11X that had previously occurred de novo in a female with typical manifestations of CHH syndrome. When the known male cases with EBP mutations were reviewed, a striking nosological difference between the mosaic and nonmosaic phenotypes was evident. Clear-cut clinical criteria are elaborated to distinguish between CHH syndrome in males and MEND syndrome.Because the clinical outcome and prognosis are different it is important to distinguish between males with CHH syndrome that represents a mosaic phenotype, and those with MEND syndrome that is a nonmosaic trait.
Determination of predominant site of airway obstruction in patients of bronchial asthma: Role of impulse oscillometry
Authors: Harmanjit Singh Hira, Amandeep Kaur
Journal: European Respiratory Journal (2011)

Background: The major site of airflow limitation in bronchial asthma varied from central to peripheral airways.

Aims and objectives: To determine predominant site of airway obstruction in patients of bronchial asthma by impulse oscillometry and flow volume loop.

Methods: Twenty five patients of asthma underwent both impulse oscillometry and flow volume loop studies. Predominant site of airway obstruction was determined by impedance spectra and visual lung model of IOS, and parameters of flow volume loop.

Results: Two patients were excluded from final analysis as their impedance spectra showed significant upper airway influence which would have made localization of site of airway obstruction invalid.

Of the 23 patients, IOS could detect obstruction in all of them (P<0.05). It revealed predominant obstruction in central airways in 15 (65.5%) and predominant peripheral airway obstruction in eight (34.5%) patients.

Flow volume loop could detect obstruction in 18 patients (78.2%). This did localise combined central and peripheral airway obstruction among 12 patients (52.2%). Six (26.1%) patients had predominant obstruction in peripheral airways.

Conclusions: To determine site of airway obstruction, impulse oscillometry has proven to be an advantageous over flow volume loop. Furthermore, it could detect airway obstruction among those patients where flow volume loop was normal.
John Tait and His Grandson
Authors: M. Therese Southgate
Journal: JAMA (2000)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Predictors of nonfetal reinfarction in survivors of myocardial infarction after thrombolysis
Authors: Alberto Volpi, Claudio De Vita, Maria Grazia Franzosi, Enrico Geraci, Aldo Pietro Maggioni, Francesco Mauri, Eva Negri, Eugenio Santoro, Luigi Tavazzi, Gianni Tognoni
Journal: Journal of the American College of Cardiology (1994)
Assessment of Myocardial Viability in Patients With Previous Myocardial Infarction by Using Single-Photon Emission Computed Tomography With a New Metabolic Tracer: [123I]-16-Iodo-3-Methylhexadecanoic Acid (MIHA)
Authors: Pierre-Yves Marie, Michaël Angioï, Nicolas Danchin, Pierre Olivier, Jean M Virion, Alain Grentzinger, Gilles Karcher, Yves Juillière, Daniel Fagret, François Cherrier, Alain Bertrand
Journal: Journal of the American College of Cardiology (1997)
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Authors: Catherine M Jackson, Brian J Lipworth
Journal: JAMA (2006)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Generation and characterization of individual-specific induced pluripotent cells from patient-derived lymphoblastoid cell lines
Authors: Shadaan Zulfiqar, Radhika Menon, Tara Atmaram, Meera Purushottam, Matthew Varghese, Sanjeev Jain, Mitradas Panicker, Odity Mukherjee
Journal: Molecular Neurodegeneration (2013)

Background Alzheimer’s disease (AD) is a common neurodegenerative disorder that leads to cognitive impairment. In India, the prevalence of AD is currently ~3.5 million but due to its large population and the recent increase in longevity, is projected to increase to 7-9 million by 2020. Thus, AD is a significant burden of disease in our country. Genetic variations play a major role in AD. The apolipoprotein-E gene and in particular its e4 allele account for 20-50% of the total genetic variance in disease risk. One copy of e4 allele increases risk for AD by ~threefold, and two copies, by more than ten-fold. But still, e4 allele is neither necessary nor sufficient for the development of the disease, indicating involvement of other genetic risk factors, alone or in conjunction with the e4 allele underlying disease predisposition.