SEVERE HYPOTENSIVE REACTIONS FOLLOWING MEPROBAMATE OVERDOSAGE
Authors: A G BLUMBERG, H L ROSETT, A DOBROW
Journal: Annals of Internal Medicine (1959)

Case Reports1 September 1959SEVERE HYPOTENSIVE REACTIONS FOLLOWING MEPROBAMATE OVERDOSAGEARNOLD G. BLUMBERG, M.D., F.A.C.P., HENRY L. ROSETT, M.D., ALAN DOBROW, M.D.ARNOLD G. BLUMBERG, M.D., F.A.C.P.Search for more papers by this author, HENRY L. ROSETT, M.D.Search for more papers by this author, ALAN DOBROW, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-51-3-607 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe physician prescribing sedative drugs to an emotionally disturbed individual must always be conscious of the danger of overdosage by accident or by suicidal intent. Although meprobamate has been clinically demonstrated to be one of the safest drugs in terms of the relative absence of toxic actions of large doses, the literature contains an increasing number of reports of serious sequelae to meprobamate overdosage. Two cases where the overdosage with meprobamate was attended with severe collapse and hypotension are presented here. The clinical course and the method of treatment in both cases are of interest, and suggest the mode...Bibliography1. PowellMannKaye LWGTS: Acute meprobamate poisoning, New England J. Med. 259: 716 (Oct. 9) 1958. CrossrefMedlineGoogle Scholar2. Lockhart WE: Suicidal Miltown—hazard of overhydration in treatment, Southwestern Med. 37: 428 (July) 1956. Google Scholar3. ShaneHirsch AMS: Three cases of meprobamate poisoning, Canad. M. A. J. 74: 908-909 (June 1) 1956. MedlineGoogle Scholar4. Woodward MG: Attempted suicide with meprobamate, Northwest Med. 56: 321 (Mar.) 1957. MedlineGoogle Scholar5. Deisher JB: Ingestion of 12 gms. of meprobamate with recovery, Northwest Med. 55: 1083 (Oct.) 1956. MedlineGoogle Scholar6. HeberdenCooper PW: Attempted suicide with meprobamate treated with Leptazol, Brit. M. J. 1: 1513-1514 (June 29) 1957. CrossrefMedlineGoogle Scholar7. ScottGrimshawMolony PAMBHM: Severe hypotensive crises following treatment with meprobamate, Arch. Int. Med. 100: 484-486 (Sept.) 1957. CrossrefGoogle Scholar8. Berger FM: The chemistry and mode of action of tranquilizing drugs, Ann. New York Acad. Sc. 67: 685-700 (May 9) 1957. CrossrefMedlineGoogle Scholar9. Berger FM: The pharmacological properties of 2-methyl-2-n-propyl-1,3-propanediol dicarbamate (Miltown), a new interneural blocking agent, J. Pharmacol. and Exper. Therap. 112: 413 (Dec.) 1954. MedlineGoogle Scholar10. FosterO'MullaneGaskellChurchillDavidson CAEJPHCHC: Chlorpromazine—a study of reaction on the circulation in man, Lancet 2: 614 (Sept. 25) 1954. CrossrefGoogle Scholar11. LearChironPallin EAEIM: A clinical study of mechanisms of action of chlorpromazine, J. A. M. A. 163: 30-36 (Jan. 5) 1957. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: *Received for publication March 23, 1959.From the Department of Internal Medicine and the Psychiatric Service, Hillside Hospital, Glen Oaks, N. Y.Requests for reprints should be addressed to Arnold G. Blumberg, M.D., Hillside Hospital, Post Office Box 38, Glen Oaks, N. Y. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byMeprobamateMuscle RelaxantsCarisoprodol Intoxications and Serotonergic FeaturesContinuous Arteriovenous Hemoperfusion in Meprobamate PoisoningBarbiturate and Nonbarbiturate Sedative Hypnotic Intoxication in ChildrenDiagnosis and Treatment of Drug OverdoseTreatment of meprobamate overdose with repeated oral doses of activated charcoalTreatment of Hypotension in Meprobamate PoisoningMeprobamate Overdosage: A Continuing ProblemAcute Meprobamate Poisoning with Gastrotomy and Removal of a Drug-Containing MassDrug levels in cases of poisoningAccidental Ingestion and Overdosage Involving Psychopharmacologic Drugs 1 September 1959Volume 51, Issue 3Page: 607-612KeywordsAddictionComaEmotionsHospital medicineHydrochloric acidHypotensionIngestionNorepinephrineSedatives ePublished: 1 December 2008 Issue Published: 1 September 1959 PDF downloadLoading ...