tbuckley/cabot-search huggingface dataset:
A Public Health Approach to Gun Violence
Authors: Shannon Frattaroli, Daniel W. Webster, Garen J. Wintemute
Journal: Annals of Internal Medicine (2013)

LettersAugust 20, 2013A Public Health Approach to Gun ViolenceShannon Frattaroli, PhD, MPH, Daniel W. Webster, ScD, MPH, and Garen J. Wintemute, MD, MPHShannon Frattaroli, PhD, MPHFrom Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland; and University of California, Davis, Davis, California.Search for more papers by this author, Daniel W. Webster, ScD, MPHFrom Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland; and University of California, Davis, Davis, California.Search for more papers by this author, and Garen J. Wintemute, MD, MPHFrom Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland; and University of California, Davis, Davis, California.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-159-4-201308200-00018 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail IN RESPONSE:We appreciate the diversity of responses to our article. Dr. May's empirical work provides a patient perspective on the physician's role in gun violence prevention and is an important complement to the 5 strategies we discuss. As other readers consider whether and how to incorporate more strategies for gun violence prevention into their professional practice, the relative importance of such an approach is heightened by Congress's recent decision not to expand background checks to include all Internet and gun show sales. In a political climate where lawmakers fail to legislate the systemic reforms that most of the population ... Author, Article, and Disclosure InformationAffiliations: From Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland; and University of California, Davis, Davis, California.Disclosures: Disclosures can be viewed at www.acponline.org/authors/icmje/ConflictOfInterestForms.do?msNum=M13-0283. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoImplementing a Public Health Approach to Gun Violence Prevention: The Importance of Physician Engagement Shannon Frattaroli , Daniel W. Webster , and Garen J. Wintemute A Public Health Approach to Gun Violence John P. May A Public Health Approach to Gun Violence James R. Gould Metrics August 20, 2013Volume 159, Issue 4Page: 306-307KeywordsBehaviorFirearm injuriesInternetPrevention, policy, and public healthViolent crime ePublished: 20 August 2013 Issue Published: August 20, 2013 CopyrightCopyright © 2013 by American College of Physicians. All Rights Reserved.PDF DownloadLoading ...
Negative regulation of hepatocellular carcinoma cell growth by signal regulatory protein ?1
Authors: He-Xin Yan, Hong-Yang Wang, Rui Zhang, Lei Chen, Bao-An Li, Shu-Qin Liu, Hui-Fang Cao, Xiu-Hua Qiu, Yun-Feng Shan, Zhong-Hua Yan, Hong-Ping Wu, Ye-Xiong Tan, Meng-Chao Wu
Journal: Hepatology (2004)

Signal regulatory protein (SIRP) α1 is a member of the SIRP family that undergoes tyrosine phosphorylation and binds SHP-2 tyrosine phosphatase in response to various mitogens. The expression levels of SIRPα1 were decreased in HCC tissues, compared with the matched normal tissues. Exogenous expression of wild type SIRPα1, but not of a mutant SIRPα1 lacking the tyrosine phosphorylation sites, in SIRPα1-negative Huh7 human HCC cells resulted in suppression of tumor cell growth both in vitro and in vivo . Treatment of Huh7 transfectants with EGF or HGF induced tyrosine phosphorylation of SIRPα1 and its association with SHP-2, which were accompanied by reduced ERK1 activation. Expression of SIRPα1 significantly suppressed activation of NF-κB and also sensitized Huh7 cells to TNFα or cisplatin-induced cell death. In addition, SIRPα1-transfected Huh7 cells displayed reduced cell migration and cell spreading in a fashion that was dependent on SIRPα1/SHP-2 complex formation. In conclusion , a negative regulatory effect of SIRPα1 on hepatocarcinogenesis is exerted, at least in part, through inhibition of ERK and NF-κB pathways. (Hepatology 2004;40:618-628.)
Mitochondrial Donation — How Many Women Could Benefit?
Authors: Gráinne S Gorman, John P Grady, Doug M Turnbull
Journal: New England Journal of Medicine (2015)

Mitochondrial disease is maternally inherited and refractory to treatment, but assisted reproduction methods can result in unaffected pregnancies. The authors provide estimates of the number of affected pregnancies per year in the United Kingdom and the United States.
Reviews and Notes: Dermatology: Eye and Skin Disease
Authors: J. B. Ross
Journal: Annals of Internal Medicine (1996)

Literature of Medicine15 October 1996Reviews and Notes: Dermatology: Eye and Skin DiseaseJ. B. Ross, MB, BS, FRCPCJ. B. Ross, MB, BS, FRCPCDalhousie University, Halifax, Nova Scotia, B3H 2Y9, CanadaSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-125-8-199610150-00039 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail MJ Mannis, MS Macsai, and AC Huntley; eds. 685 pages. Philadelphia: Lippincott-Raven; 1995. $225.00. ISBN 0781702690. Order phone 800-777-2295.My teacher introduced dermatology to neophytes by drawing an oval. He would put a dimple in the top, and in the final diagram, the dimple was absorbed, becoming the notocord in cross-section. The ectoderm is intimately related to the mesoderm and its derivatives. As the authors note, this has been known for centuries. And yet few monographs relate eye and skin disease. The National Library shows only one text in English in this category.This text is timely and is directed ... Author, Article, and Disclosure InformationAffiliations: Dalhousie University, Halifax, Nova Scotia, B3H 2Y9, Canada PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 15 October 1996Volume 125, Issue 8Page: 703-704KeywordsDermatologyEmergency departmentEye diseasesGeneticsLibrariesLupus erythematosusOphthalmologyPrimary care physiciansSjogren syndromeSkin diseases ePublished: 15 August 2000 Issue Published: 15 October 1996 Copyright & PermissionsCopyright © 1996 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Enterectomy for Gangrenous Hernia
Authors: W. P. Montgomery
Journal: BMJ (1900)

THIE interest which the question of the treatment of gan- grenous hernia is now exciting makes the following success- ful cases of resection and primary suture woa thy of record.They were both operated on in the Manchester Royal Infirmary, and I am indebted to Mr. Hardie and to Mr. Soutbam, for whom I was respectively acting at the time, for permission to publish them.CASE I.
AN IMPROVED TEST OF SPERMICIDAL ACTIVITY WITHOUT DILUTION OR MIXING
Authors: Clarence J. Gamble
Journal: JAMA (1953)

Comparisons of the clinical effectiveness of contraceptive materials are difficult and subject to large errors because of the unavoidable variations in the correctness and regularity of their use. Attempts to limit observations to those who are regular users are disappointing; many who claim regularity as long as the method is successful may report irregularity of some duration after a pregnancy leads to detailed interrogation. These uncertainties in clinical testing have led to a search for laboratory procedures that may give an indication of clinical efficiency. <h3>SPERMICIDAL TESTS INVOLVING MIXING AND DILUTION</h3> Baker made a careful study of spermicidal powers by mixing equal quantities (0.3 cc.) of semen with physiological salt solutions (0.9% sodium chloride) in which various concentrations of pure substances were dissolved. He determined the lowest concentration of the substance in the final mixture that would immobilize the sperms in human semen in 30 minutes.<sup>1</sup>In testing jellies
Mechanism of the Hypolipemic Effect of Clofibrate in Postabsorptive Man
Authors: B. M. Wolfe, J. P. Kane, R. J. Havel, H. P. Brewster
Journal: Journal of Clinical Investigation (1973)

Splanchnic metabolism of triglycerides and other major substrates was studied in the postabsorptive state in normotriglyceridemic and hypertriglyceridemic human subjects who received ½ g of clofibrate four times daily for 3 wk. Transport in blood plasma of triglycerides produced in the splanchnic region was quantified by three methods: (a) measurement of the transsplanchnic gradient of 14C-labeled triglycerides during constant intravenous infusion of [1- 14C] palmitate (b) chemical measurement of the transplanchnic gradient in concentration of triglycerides of very low density lipoproteins; and (c) determination of clearance of 14C-labeled triglycerides in extrasplanchnic tissues. The first method measures only triglycerides derived from free fatty acids and the last two measure total splanchnic production. In hypertriglyceridemic subjects treated with clofibrate, average rates of total splanchnic production of triglycerides and production from free fatty acids were the same as those of comparable untreated subjects despite a consistent fall in plasma triglyceride levels. The hypotriglyceridemic effect of the drug was therefore accompanied by improved disposal of triglycerides in extrasplanchnic tissues. In treated normotriglyceridemic subjects, unlike their untreated counterparts, total splanchnic production was significantly higher than production from free fatty acids. Failure of clofibrate to reduce triglyceride levels in normotriglyceridemic subjects may have been related to increased total splanchnic production, coupled with improved extrasplanchnic disposal.
Epistemological requirements for a cognitive psychology of real people
Authors: John Campion
Journal: Behavioral and Brain Sciences (2005)

Pothos's analysis is difficult to relate to real human mental processes. He tackles four quite different areas of psychology and adduces evidence from a large number of paradigms. Yet despite this very large scope, he employs a single, simplistic descriptive framework. An epistemological analysis, supported by illustrations from real world decision-making, shows that this steers us away from, rather than towards, an understanding of real human cognitive processes.
The BMJ Awards India: And the winners are . . . robotic spinal surgery, hospital stewardship of antibiotics, and primary care for hill tribes
Authors: R. Hurley
Journal: BMJ (2014)

Judges chose 10 nominations that showcased a breadth of medical innovation in India and that have the potential to make substantial improvements to health in the country. <b>Richard Hurley</b> reports from the inaugural BMJ Awards India in New Delhi
Dupuytren's Contracture and Its Surgical Treatment
Authors: Walter E. Heyse
Journal: JAMA (1960)

The long preferred method of treatment of Dupuytren's contracture has been total palmar fasciectomy. The results of this treatment have generally been satisfactory, but objections are raised to this procedure in that a long convalescence is required, secondary skin coverage is not infrequently necessary, and the occasional poor result leaves the patient with a virtually functionless hand. In this study of a limited resection operation for Dupuytren's contracture it was found that satisfactory function, short convalescence, and a rapid return to normal activities could be obtained without the danger of a disastrous result. When the operation was performed for the indication of contracture in 12 hands, no recurrence was noted in follow-ups ranging from 1 to 5 years.
Physicians Provide Continuum of Care for Desert Storm Fighting Forces
Authors: Phil Gunby
Journal: JAMA (1991)

DESERT STORM combat medical plans call for a continuum of care from the Middle East's frontlines to US hospitals. Wounds to the extremities have been the most common for US soldiers in wars of the latter half of this century and that is projected to be true again for US forces in the current coalition effort to oust the Iraqi invaders from Kuwait. In the recent past, wounded who have lived to reach a military hospital usually have survived and this also is expected to continue to be the case now for US forces in the Persian Gulf area. <h3>Desert Shield/Storm</h3> Still, unofficial casualty projections— as the 5-month Operation Desert Shield buildup of forces moved into the post-United Nations deadline Operation Desert Storm combat phase (January 16)—vary from 1800 (300 dead) to well over 45 000 (10 000 or more dead) among the 28 allied nations and up to 60
Mental Retardation and Schizophrenia
Authors: Nathan S. Kline
Journal: JAMA (1963)

<h3>To the Editor:</h3> —Dr. Klein raises an interesting and important point which I correctly but neatly sidestepped in my previous reply. This is the distinction between a mental defective (oligophrenic) and mental retardation. When Dr. Klein states that I indicate that schizophrenia may result in mental retardation, this is precisely the case. By mental retardation I very clearly mean the retarding of mental processes, regardless of the cause. There is a considerable literature on this subject including differential diagnosis (Bender, Kanner, Fish, Eisenberg, Goldfarb, etc.). Oligophrenia constitutes one type of mental retardation and, in the given case histories of the twins, the fact that presumably they developed normally until the age of 4 yr specifically rules out congenital oligophrenia. The coexistence of oligophrenia and schizophrenia has long been recognized and is described in the European literature under the term "propf schizophrenia." I would further concur that clear delineation of diagnostic
Shall The Journal be Removed to Washington?-Reply
Authors: Joseph Waggoner
Journal: JAMA (1891)

<h3>To the Editor:</h3> —I say yes. Washington is not a place of common trade or manufacture, as are other cities of our country. It is our capital, with its many attractions, the pride of the American citizen. It should be made the headquarters of the arts and sciences.The Journalshould be placed with the Medical Museum and Library, and all physicians should have pride enough for their profession and country to cheerfully support it, so as to make it the peer in medical literature of the journals of any country. WhatThe Journalmost needs and should have is the united support of the medical profession. Ravenna, O.
Sensitization to P.A.S., Streptomycin, and Isoniazid
Authors: P. Macpherson
Journal: BMJ (1957)

PERTUSSIS VACCINE BDNRITSuAH 505 is greater than the value of the L.F.L. Thus, if we require that the L.F.L. should exceed the minimum potency we wish to secure, the " desirable " potency, we shall be fairly safe in assuming that accepted batches are of satisfactory quality.However, we do not know the " desirable " potency exactly, and we shall err on the safe side if we use the upper fiducial limits (U.F.L.) given in Tables IV andV: (a) assuming no deterioration (Table V), the " de3irable" potency has a U.F.L. of 0.66 times the standard; and 0b) assuming deterioration to have occurred (Table IV), the "desirable " potency has a U.F.L. of 3.2 times the standard.If we now require that the L.F.L. of the estimated potency in a routine assay shall exceed one of these levels -narmely, 0.66 or 3.2 times the standard-we shall hare a high probability that the true potency of the vaccine exceeds the true va'ue of the " desirable " level.Furthermore, if we require that the L.F.L. in a routine assav shall be greater than 50% of the estimated potency, then we must set the requirement for estimated potency at about 1.3 and 6.4 times the standard.These are the two extremes.The choice might fall on either, or on some figure intermediate between them.As we have seen, whatever the choice may be, it must be arbitrary, and it mnust lie with the legal authorities.We can, however, conclude that a measure of control is now practicable, and we would accordingly endorse the recommendation to this effect in the M.R.C. report.
Heparin prophylaxis has no benefit in medical patients
Authors: M. Snee
Journal: BMJ (2012)

The article on the introduction of methods to encourage or mandate the prescription of prophylaxis for venous thromboembolism (VTE) is misconceived.1 It is not true that most cases of deep vein thrombosis (DVT) in medical patients can be prevented. A recent meta-analysis found that symptomatic DVT occurred in 0.79% of patients given prophylaxis with heparin …
Association analysis of filaggrin gene mutations and atopic dermatitis in Northern China
Authors: L. Ma, L. Zhang, Z-H. Di, L-P. Zhao, Y-N. Lu, J. Xu, H-D. Chen, X-H. Gao
Journal: British Journal of Dermatology (2009)

Journal Article Association analysis of filaggrin gene mutations and atopic dermatitis in Northern China Get access L. Ma, L. Ma State Key Department of Dermatology, No. 1 Hospital of China Medical University, 155 North Nanjing Street, Shenyang 110001, ChinaDepartment of Dermatology, Binzhou Medical College Hospital, Binzhou, China Search for other works by this author on: Oxford Academic Google Scholar L. Zhang, L. Zhang State Key Department of Dermatology, No. 1 Hospital of China Medical University, 155 North Nanjing Street, Shenyang 110001, China Search for other works by this author on: Oxford Academic Google Scholar Z‐H. Di, Z‐H. Di Department of Dermatology, Shengjing Hospital of China Medical University, Shenyang, China Search for other works by this author on: Oxford Academic Google Scholar L‐P. Zhao, L‐P. Zhao Department of Dermatology, The General Hospital of Shenyang Military Command, Shenyang, China Search for other works by this author on: Oxford Academic Google Scholar Y‐N. Lu, Y‐N. Lu Department of Dermatology, Shengjing Hospital of China Medical University, Shenyang, China Search for other works by this author on: Oxford Academic Google Scholar J. Xu, J. Xu Department of Dermatology, Shengjing Hospital of China Medical University, Shenyang, China Search for other works by this author on: Oxford Academic Google Scholar H‐D. Chen, H‐D. Chen State Key Department of Dermatology, No. 1 Hospital of China Medical University, 155 North Nanjing Street, Shenyang 110001, China Search for other works by this author on: Oxford Academic Google Scholar X‐H. Gao X‐H. Gao State Key Department of Dermatology, No. 1 Hospital of China Medical University, 155 North Nanjing Street, Shenyang 110001, China Xing‐Hua Gao. E‐mail: gaobarry@hotmail.com Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 162, Issue 1, 1 January 2010, Pages 225–227, https://doi.org/10.1111/j.1365-2133.2009.09539.x Published: 01 January 2010
The price of smoking
Authors: Shyam Biswal
Journal: Journal of Clinical Investigation (2005)

rent discovery efforts do not necessarily warrant assumption of the practical utility of the SNP constellations in creating diagnostic predictor kits.Throughout these penetrating interviews, Rabinow urges the readers to formulate their own opinions regarding issues such as the differences between monogenic and polygenic diseases and the utility of multiplex modeling in developing diagnostic tests based on functional SNPs.Rabinow's fascinating chronicle ends in 2003, at which time Celera Diagnostics became operational.Whether or not Celera Diagnostics can advance SNP-based diagnostics to realize targeted medicine in the future all depends on its progress in the race to unravel the SNP constellations and ultimately to successfully configure predictive diagnostic kits.However, even now in 2005, it still remains for the company to deliver on its promise.Nevertheless, this biotech chronicle not only appeals as a stimulating bedtime read but also serves as a unique historical account of Celera Diagnostics.
ALKALI POISONING: A DANGER IN THE TREATMENT OF GASTRIC ULCER
Authors: C. L. Cope
Journal: BMJ (1936)

ALKALI POISONINGMTHE BRDTIA U These drugs exert their peculiar action -only on subjects, either male or female, who have passed the change of life."Susceptibility to this action is probably associated with an alteration in the nature or balance of the sex hormones.
The Protection of Personnel Engaged in Roentgenology and Radiology
Authors: F. T. Hunter, L. L. Robbins
Journal: New England Journal of Medicine (1951)

IN A preliminary report1 a film badge was described that gave quantitative information on both the amount and the quality of radiation received by personnel in the Department of Radiology of the Massachusetts General Hospital. It was also planned to see if these measurements could be correlated with changes in the peripheral blood picture over a long period. The present communication, however, brings this study to a close, because all personnel are now subject to exposures far below the effective biologic level, and no statistical evidence could be obtained that radiation was affecting, or had affected, the peripheral blood picture. . . .
TCT-817 Hemodynamic Challenges and Efficacy of Vasodilator-enhanced Antegrade Intracoronary AAV9 Gene Delivery with and without Coronary Sinus Blockage
Authors: Felix Woitek, MaryKathryn Hurst, Jeffrey C. Powers, Anna M. Kulczycki, Amy Lam, Abdelkarim Sabri, Fabio A. Recchia
Journal: Journal of the American College of Cardiology (2013)
Microbial endocrinology
Authors: Mark Lyte
Journal: Gut Microbes (2014)

The ability of microorganisms, whether present as commensals within the microbiota or introduced as part of a therapeutic regimen, to influence behavior has been demonstrated by numerous laboratories over the last few years. Our understanding of the mechanisms that are responsible for microbiota-gut-brain interactions is, however, lacking. The complexity of the microbiota is, of course, a contributing factor. Nonetheless, while microbiologists approaching the issue of microbiota-gut-brain interactions in the behavior well recognize such complexity, what is often overlooked is the equal complexity of the host neurophysiological system, especially within the gut which is differentially innervated by the enteric nervous system. As such, in the search for common mechanisms by which the microbiota may influence behavior one may look for mechanisms which are shared by both host and microbiota. Such interkingdom signaling can be found in the shared production of neurochemical mediators that are found in both eukaryotes and prokaryotes. The study of the production and recognition of neurochemicals that are exactly the same in structure to those produced in the vertebrate organisms is known as microbial endocrinology. The examination of the microbiota from the vantage point of host-microbiota neuroendocrine interactions cannot only identify new microbial endocrinology-based mechanisms by which the microbiota can influence host behavior, but also lead to the design of interventions in which the composition of the microbiota may be modulated in order to achieve a specific microbial endocrinology-based profile beneficial to overall host behavior.