CHRONIC NEUTROPENIA IN SIBLINGS: THE EFFECT OF STEROIDS
Authors: P L ROSSMAN, G J HUMMER
Journal: Annals of Internal Medicine (1960)

Case Reports1 January 1960CHRONIC NEUTROPENIA IN SIBLINGS: THE EFFECT OF STEROIDSPHILLIP L. ROSSMAN, M.D., GEORGE J. HUMMER, M.D.PHILLIP L. ROSSMAN, M.D.Search for more papers by this author, GEORGE J. HUMMER, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-52-1-242 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe literature is replete with articles on the use of steroids in the treatment of drug-induced agranulocytosis but not with articles on nondrug-induced, non-cyclic, nonsplenic neutropenia. Two cases of the latter type in siblings are presented, in the second of whom a favorable response to steroid therapy was obtained.The mother of these children has a duodenal ulcer and disseminated lupus erythematosus, currently controlled with the use of prednisone. Her blood count and peripheral blood picture have always been normal. Examination of her bone marrow revealed numerous L.E. cells of the Hargraves' type. The children's father had had a coronary...Bibliography1. Chaiken BH: Effect of ACTH in periodic (cyclic) neutropenia, Blood 9: 83-89 (Jan.) 1954. CrossrefMedlineGoogle Scholar2. MontoShaferBrennanRebuck RWHCMJJW: Periodic neutropenia treated by adrenocorticotrophic hormone and splenectomy; report of case, New England J. Med. 246: 893-896 (June 5) 1952. CrossrefMedlineGoogle Scholar3. McMillin JS: Successful use of ACTH in treatment of agranulocytosis due to sulfadiazine, Am. J. M. Sc. 222: 392-395 (Oct.) 1951. CrossrefMedlineGoogle Scholar4. SpaetDameshek THW: Chronic hypoplastic neutropenia, Am. J. Med. 13: 35-45, 1952. CrossrefMedlineGoogle Scholar5. BousserNeydé JR: La neutropénie familiale, Sang 18: 521-529, 1957. Google Scholar6. Gänsslen M: Konstitutionelle familiare Leukopénie (Neutropénie), Klin. Wchnschr. 20: 922-925 (Sept. 13) 1941. CrossrefGoogle Scholar7. Béguez César A: Neutropenia crónica maligna familiar con granulaciones atípicas de los leucocitos, Bol. Soc. cubana de pediat. 15: 900-922 (Dec.) 1943. Google Scholar8. Reimannde Berardinis HACT: Periodic (cyclic) neutropenia; an entity, Blood 4: 1109 (Oct.) 1941. CrossrefGoogle Scholar9. Sturgis CC: Hypersplenism, a clinical evaluation, 1953, Charles C Thomas, Springfield, Ill. Google Scholar10. SchwartzHass RSWK: Leucoagglutinins in agranulocytosis, Arch. Int. Med. 95: 868 (June) 1955. CrossrefGoogle Scholar11. WalfordPetersonDoyle RLETP: Leukocyte antibodies in human sera and in immune rabbit sera, Blood 12: 953 (Nov.) 1957. CrossrefMedlineGoogle Scholar12. DowneyMcKinlay HCA: Acute lymphadenosis compared with acute lymphatic leukemia, Arch. Int. Med. 32: 82-112 (July) 1923. CrossrefGoogle Scholar13. LitwinsLeibowitz JS: Abnormal lymphocytes ("virocytes") in virus diseases other than infectious mononucleosis, Acta haemat. 5: 223-231 (Apr.) 1951. CrossrefMedlineGoogle Scholar14. HavensMarck WPRE: Leukocyte response of patients with experimentally induced infectious hepatitis, Am. J. M. Sc. 212: 129-138 (Aug.) 1946. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: *Received for publication September 17, 1958.From Saint John's Hospital, Santa Monica, California.Requests for reprints should be addressed to George J. Hummer, M.D., Saint John's Hospital, Santa Monica, California. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byHyper-IgM, Neutropenia, Mild Infections and Low Response to Polyclonal Stimulation: Hyper-IgM Syndrome or Common Variable Immunodeficiency?Severe chronic neutropenia: Treatment and follow-up of patients in the Severe Chronic Neutropenia International RegistryImpaired Resistance to InfectionChronic neutropenia presenting with oral lesionsFamilial granulocytopenia and associated immunoglobulin abnormality�ber die famili�re NeutropenieChronic benign neutropenia of childhood with associated oral manifestationsFamilial Benign Chronic NeutropeniaHUNTER O. CUTTING, J. EUGENE LANGCongenital Neutropenia: A Report of Five CasesDie chronische, konstitutionelle Neutropenie mit Lymphocytose im S�uglings- und KleinkindesalterWhite Blood Cell DisordersFamilial Neutropenia Possibly Caused by Deficiency of a Plasiiia FactorCyclic Neutropenia Report on Three CasesMedical genetics 1960�ber angeborene Defekte humoraler und cellul�rer Abwehr 1 January 1960Volume 52, Issue 1Page: 242-254KeywordsChildrenDrugsDuodenal ulcersLupus erythematosusNeutropeniaSepsisSteroid therapySteroidsUlcersUpper respiratory tract infections ePublished: 1 December 2008 Issue Published: 1 January 1960 PDF downloadLoading ...