THE PARENTERAL USE OF SODIUM LACTATE SOLUTION IN THE PREVENTION OF RENAL COMPLICATIONS FROM PARENTERALLY ADMINISTERED SODIUM SULFADIAZINE
Authors: D. Rourke Gilligan, James A. Dingwall, Walsh Mcdermott
Journal: Annals of Internal Medicine (1944)

Article1 April 1944THE PARENTERAL USE OF SODIUM LACTATE SOLUTION IN THE PREVENTION OF RENAL COMPLICATIONS FROM PARENTERALLY ADMINISTERED SODIUM SULFADIAZINED. ROURKE GILLIGAN, JAMES A. DINGWALL 3D, WALSH MCDERMOTTD. ROURKE GILLIGANSearch for more papers by this author, JAMES A. DINGWALL 3DSearch for more papers by this author, WALSH MCDERMOTTSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-20-4-604 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptRecent studies in this hospital1 and in other clinics2 have demonstrated the effectiveness of adjuvant alkali therapy in preventing renal complications from sulfadiazine. This protective action is attributable to the fact that alkalinization of the urine increases the solubility of sulfadiazine and its N4-acetyl derivative1, 3, 4 and thereby prevents their precipitation in the kidneys and urinary tract.The optimal dosage and mode of administration of alkali during oral therapy with sulfadiazine have been studied in a large series of patients.1Alkalinization of the urine during parenteral therapy with sodium sulfadiazine presents a special problem which is the subject of...Bibliography1. GILLIGANGARBWHEELERPLUMMER DRSCN: Adjuvant alkali therapy in the prevention of renal complications from sulfadiazine, Jr. Am. Med. Assoc., 1943, cxxii, 1160. CrossrefGoogle Scholar2. FOXJENSENMUDGE CLOJGH: The prevention of renal obstruction during sulfadiazine therapy, Jr. Am. Med. Assoc., 1943, cxxi, 1147. CrossrefGoogle Scholar3. JENSENFOX OJCL: Hydrogen ion concentration and the solubility of sulfonamides in urine; the relation to renal precipitation, Jr. Urol., 1943, xlix, 334. CrossrefGoogle Scholar4. GILLIGANGARBPLUMMER DRSN: Prevention of crystalluria during sulfadiazine therapy. Experimental and clinical studies, Proc. Soc. Exper. Biol. and Med., 1943, lii, 248. CrossrefGoogle Scholar5. BRATTONMARSHALL ACEK: A new coupling component for sulfanilamide determination, Jr. Biol. Chem., 1939, cxxviii, 537. CrossrefGoogle Scholar6. VAN SLYKENEILL DDJM: See PETERS J. P., and VAN SLYKE D. D., Quantitative Clinical Chemistry. Methods, 1932, Williams and Wilkins Company, Baltimore, vol. II, p. 284. Google Scholar7. PLUMMERWHEELER NC: The toxicity of sulfadiazine. Observations on 1357 cases, Am. Jr. Med. Sci., 1944, ccvii, 175. CrossrefGoogle Scholar8. GAMBLE JL: Carbonic acid and bicarbonate in urine, Jr. Biol. Chem., 1922, li, 295. CrossrefGoogle Scholar9. HARTMANNSENN AFMJ: Studies in the metabolism of sodium r-lactate. II. Response of human subjects with acidosis to the intravenous injection of sodium r-lactate, Jr. Clin. Invest., 1932, xi, 337. CrossrefGoogle Scholar10. GILLIGAN DR: Blood levels of sulfadiazine, sulfamerazine, and sulfamethazine in relation to binding in the plasma, Jr. Pharmacol. and Exper. Therap., 1943, lxxix, 320. Google Scholar11. REINHOLDFLIPPINSCHWARTZDOMM JGHFLAH: The absorption, distribution, and excretion of 2-sulfanilamido pyrimidine (sulfapyrimidine, sulfadiazine) in man, Am. Jr. Med. Sci., 1941, cci, 106. CrossrefGoogle Scholar12. HEINEMANN M: Distribution of sulfonamide compounds between cells and serum of human blood, Jr. Clin. Invest., 1943, xxii, 29. CrossrefGoogle Scholar13. HARTMANNSENN AFMJ: Studies in the metabolism of sodium r-lactate. I. Response of normal human subjects to the intravenous injection of sodium r-lactate, Jr. Clin. Invest., 1932, xi, 327. CrossrefGoogle Scholar14. HARTMANNSENN AFMJ: Studies in the metabolism of sodium r-lactate. III. Response of human subjects with liver damage, disturbed water and mineral balance, and renal insufficiency to the intravenous injection of sodium r-lactate, Jr. Clin. Invest., 1932, xi, 345. CrossrefGoogle Scholar15. HARTMANNPERLEYBASMANNELSONASHER AFAMJMVC: Further observations on the metabolism and the clinical uses of sodium lactate, Jr. Pediat., 1938, xiii, 692. CrossrefGoogle Scholar16. SELLARDS AW: The determination of the equilibrium in the human body between acids and bases with especial reference to acidosis and nephropathies, Bull. Johns Hopkins Hosp., 1912, xxiii, 289. Google Scholar17. PALMERHENDERSON WWLJ: Clinical studies on acid base equilibrium and the nature of acidosis, Arch. Int. Med., 1913, xii, 153. CrossrefGoogle Scholar18. MYERHOFLOHMANN OK: Über Atmung und Kohlehydratumsatz tierischer Gewebe. III. Über den Unterschied von d- und l-Milchsäure für Atmung und Kohlehydratsynthese im Organismus, Biochem. Ztschr., 1926, clxxi, 421. Google Scholar19. CORICORI CFGT: Glycogen formation in the liver from d- and l-lactic acid, Jr. Biol. Chem., 1929, lxxxi, 389. CrossrefGoogle Scholar20. PETERSVAN SLYKE JPDD: Quantitative clinical chemistry. Interpretations, 1935, Williams and Wilkins Company, Baltimore, vol. I, p. 973. Google Scholar21. PALMERVAN SLYKE WWDD: Studies of acidosis. IX. Relationship between alkali retention and alkali reserve in normal and pathological individuals, Jr. Biol. Chem., 1917, xxxii, 499. CrossrefGoogle Scholar22. TAPLINCUSTERYOUNG GVEALE: The sodium salts of sulfapyridine, sulfathiazole and sulfadiazine. Their clinical use by hypodermoclysis, Jr. Am. Med. Assoc., 1943, cxxi, 313. CrossrefGoogle Scholar23. HARTMANNWOLFFLOVEKENDALL AFDFMBS: Diagnosis and management of severe infections in infants and children. A review of experiences since the introduction of sulfonamide therapy. II. Hemolytic streptococcal meningitis, Jr. Pediat., 1942, xxi, 591. CrossrefGoogle Scholar24. WHEELERPLUMMER CN: Sulfadiazine and sodium sulfadiazine: A comparison of certain of their clinical and pharmacologic values, ANN. INT. MED., 1942, xvi, 269. Google Scholar25. DOWLINGLEPPER HFMH: Toxic reactions following therapy with sulfapyridine, sulfathiazole and sulfadiazine, Jr. Am. Med. Assoc., 1943, cxxi, 1190. CrossrefGoogle Scholar26. HALLSPINK WHWW: Sulfamerazine: clinical evaluation in 116 cases, Jr. Am. Med. Assoc., 1943, cxxiii, 125. CrossrefGoogle Scholar27. LEPPERSWEETDOWLING MHLKHF: The treatment of meningococcic infections with sulfadiazine and sulfamerazine (sulfamethyldiazine, monomethyl-sulfadiazine), Jr. Am. Med. Assoc., 1943, cxxiii, 134. CrossrefGoogle Scholar28. MCDERMOTTGILLIGANWHEELERPLUMMER WDRCN: Clinical studies of sulfamethazine, New York State Jr. Med., 1944, xliv, 394. Google Scholar29. RUEGSEGGERBROOKENSHAMBURGERGRUPEN JMNLMES: The treatment of pneumococcal pneumonia with sulfapyrazine, Am. Jr. Med. Sci., 1943, ccvi, 323. CrossrefGoogle Scholar30. MACARTNEYSMITHLUXTONRAMSEYGOLDMAN DWGSRWWAJ: Sulfamethazine: clinical trial of a new sulfonamide, Lancet, 1942, i, 639. CrossrefGoogle Scholar31. CLIMENKOBARLOWWRIGHT DROWAW: Influence of sodium bicarbonate in preventing renal lesions from massive doses of sulfathiazole, Arch. Path., 1941, xxxii, 889. Google Scholar32. GILLIGANPLUMMER DRN: Comparative solubilities of sulfadiazine, sulfamerazine, and sulfamethazine and their N4-acetyl derivatives at varying pH levels, Proc. Soc. Exper. Biol. and Med., 1943, liii, 142. CrossrefGoogle Scholar33. HAMBURGERRUEGSEGGERBROOKENSEAKIN MJMNLE: The absorption, excretion and distribution of 2-sulfanilamidopyrazine (sulfapyrazine) in man, Am. Jr. Med. Sci., 1942, cciv, 186. CrossrefGoogle Scholar34. SCHWARTZFLIPPINREINHOLDDOMM LHFJGAH: The effect of alkali on crystalluria from sulfathiazole and sulfadiazine, Jr. Am. Med. Assoc., 1941, cxvii, 514. CrossrefGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: New York, N. Y.*Received for publication January 26, 1944.With the technical assistance of Edith M. Beck and Mary A. Cooper.From the Departments of Medicine and Surgery, Cornell University Medical College, and The New York Hospital, New York.†Eleven hundred c.c. were chosen since the contents of the infusion bottles of the prepared solutions used were 550 c.c. each. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byACUTE SUPPURATIVE BRONCHITIS AND BRONCHIOLITIS IN CHRONIC PULMONARY DISEASE: DIAGNOSIS AND MANAGEMENT*LEONARD CARDON, M.D., F.A.C.P., LOUIS LEMBERG, M.D., REGINA S. GREENEBAUM, M.D.Subcutaneous administration of sodium sulfadiazineThe Present Status of Sulfonamide TherapyThe Treatment of Renal Obstruction Resulting Fromsulfadiazine and Sulfamerazine 1 April 1944Volume 20, Issue 4Page: 604-618KeywordsHospital medicineKidneysLactatesResearch designSodiumSurgeryUrine ePublished: 1 December 2008 Issue Published: 1 April 1944 PDF downloadLoading ...