tbuckley/cabot-search huggingface dataset:
γA-BLOOD GROUP ANTIBODIES
Authors: M. Adinolfi, P. L. Mollison, Margaret J. Polley, Jane M. Rose
Journal: The Journal of Experimental Medicine (1966)

The serological characteristics of γA-anti-A and anti-B were studied using, as a source, either colostrum, or fractions relatively rich in γA obtained from selected potent antisera. γA-anti-A and anti-B were never hemolytic nor did they sensitize red cells to agglutination by anticomplement globulin sera. γA-anti-A, like γG-anti-A and unlike γM-anti-A was unaffected by heating at 56°C for 3 hr. On the other hand in the following three characteristics the behavior of γA fell between that of γG- or γM-anti-A: sensitivity to inactivation by 2-mercaptoethanol, ease of neutralization by A substance and degree of enhancement of agglutination in a medium of serum rather than saline. The agglutination produced by γA-anti-A was regularly enhanced by addition of anti-γA-globulin serum. In searching for γA-blood group antibodies of other specificities the following sera were tested: anti-D (32 examples); anti-c (2 examples); anti-Lea or -Leb (3 examples); anti-K (3 examples); anti-Fya (3 examples), and anti-Jka (3 examples). Only 3 sera, all containing anti-D, sensitized red cells to agglutination by anti-γA. There were no discrepancies between results obtained with four different anti-γA-globulin sera. Approximately half the sera were fractionated on DEAE-cellulose, and the fractions rich in γA tested for their ability to sensitize red cells to agglutination by anti-γA; no additional examples of γA-antibodies were detected. One of the three examples of γA-anti-D appeared in the serum of a woman during the course of deliberate reimmunization. γA-anti-D appeared only after three intravenous injections of red cells although the γG-anti-D titer rose considerably after a single injection. 3 yr after a fourth injection of Rh-positive cells γA-anti-D, as well as γG-anti-D, was still present in the serum.
Clinical and demographic characteristics of the tuberculin skin test positive patients without active tuberculosis contact
Authors: Ahmet Hakan Gedik, Erkan Cakir, Tugrul Donmez, Engin Ari, Kaya Koksalan
Journal: European Respiratory Journal (2013)

Introduction: Tuberculin skin test (TST) is still one of the most significant test used to find out tuberculosis (TB). It is very common to come across false positive TST results due to BCG vaccines applied routinely in countries. Aim: To evaluate the patients who was referred to us who had positive TST without any TB contact. Method: 171 patients were prospectively followed up between September 2011 and February 2013. Result: 51% of the patients were male, the median age was 84 months and the median duration of the symptoms was 5 months. The indications of TST were cough (77%), sputum (36%), wheezing (30%), dyspnoea (18%), cervical lympho-adenopathy (7%). 43% of chest X-rays were normal and increase of bronchovasculary signs (22%), bronchopnomonic infiltrations (18%), suspicious lympho-adenopathy view (17%) were other findings. 49% of the patients had CT and the results were normal in 56%. Right middle lob atelectasis (n=15), infiltration (n=13) and big lymp nodes (n=12) were detected. Interferon gama release assay was performed in 81% of the patients and 96% of them were normal. 15% required to microbiological tests and all were negative The patients follow up period was 12,4 ±3,7 months. The most common diagnosis established with the patients were asthma (% 47), alergic rhinitis (17%), and reactive lympho-adenitis (7%). Conclusion: Active TB was not found in any positive TST without any TB contact and the most common diagnosis was asthma and allergic rhinitis. It was shown in our study that the false positive of TST was high.
Ultraviolet radiation regulates cortisol activity in a waveband-dependent manner in human skin<i>ex vivo</i>
Authors: C. Skobowiat, R.M. Sayre, J.C. Dowdy, A.T. Slominski
Journal: British Journal of Dermatology (2013)

Journal Article Ultraviolet radiation regulates cortisol activity in a waveband‐dependent manner in human skin ex vivo Get access C. Skobowiat, C. Skobowiat Department of Pathology and Laboratory Medicine, Center for Cancer Research, University of Tennessee, Health Science Center, Memphis, TN 38163, U.S.A Search for other works by this author on: Oxford Academic Google Scholar R.M. Sayre, R.M. Sayre Rapid Precision Testing Laboratories, Cordova, TN 38016, U.S.ADivision of Dermatology of the Department of Medicine, University of Tennessee, Health Science Center, Memphis, TN 38163, U.S.A Search for other works by this author on: Oxford Academic Google Scholar J.C. Dowdy, J.C. Dowdy Rapid Precision Testing Laboratories, Cordova, TN 38016, U.S.A Search for other works by this author on: Oxford Academic Google Scholar A.T. Slominski A.T. Slominski Department of Pathology and Laboratory Medicine, Center for Cancer Research, University of Tennessee, Health Science Center, Memphis, TN 38163, U.S.ADivision of Dermatology of the Department of Medicine, University of Tennessee, Health Science Center, Memphis, TN 38163, U.S.A Andrzej T. Slominski E‐mail: aslominski@uthsc.edu Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 168, Issue 3, 1 March 2013, Pages 595–601, https://doi.org/10.1111/bjd.12096 Published: 01 March 2013 Article history Accepted: 07 October 2012 Published: 01 March 2013
The importance of dose intensity in chemotherapy of metastatic breast cancer.
Authors: W Hryniuk, H Bush
Journal: Journal of Clinical Oncology (1984)

Article Tools Article Tools OPTIONS & TOOLS Export Citation Track Citation Add To Favorites Rights & Permissions COMPANION ARTICLES No companion articles ARTICLE CITATION DOI: 10.1200/JCO.1984.2.11.1281 Journal of Clinical Oncology - published online before print September 22, 2016 PMID: 6387060 The importance of dose intensity in chemotherapy of metastatic breast cancer. W HryniukxW HryniukSearch for articles by this author , H BushxH BushSearch for articles by this author https://doi.org/10.1200/JCO.1984.2.11.1281 First Page PDF © 1984 by American Society of Clinical Oncology
The incidence of second primary tumors in long-term survivors of small-cell lung cancer.
Authors: K H Heyne, S M Lippman, J J Lee, J S Lee, W K Hong
Journal: Journal of Clinical Oncology (1992)

PURPOSE AND METHODS A review of 446 patients who were enrolled consecutively in small-cell lung cancer (SCLC) protocols was performed to identify in long-term survivors the frequency of new primary tumors and their clinical impact. RESULTS Forty-seven patients (10.5%) were identified to be free of disease at 2 years. Second primary tumors (SPTs) were diagnosed in 14 patients. The overall risk for developing an SPT was 10.3% per person-year. Actuarial risk at 8 years was 50.3% for an SPT. CONCLUSIONS In this review, SCLC showed one of the highest incidences of SPTs reported in aerodigestive tract malignancies. A long-term survivor was more likely to have an SPT than a relapse of SCLC. Consequently, the odds of death from an SPT compared with that from a relapse increased sharply from 1:13 within 4 years from diagnosis to 8:1 afterwards. Long-term survivors of SCLC would be excellent candidates for chemoprevention trials.
Effects of diesel exhausted particles on lung inflammation in OVA-sensitized and single challenged mice
Authors: Gabriel Ribeiro de Freitas, Juliana Nascimento, Flávia Greiffo, Thayse Bruggemann, Leonardo Ávila, Franciane Bobinski, Regiani Carvalho, Adair Santos, Rodolfo Vieira, Deborah Hizume
Journal: European Respiratory Journal (2013)

Background : The deleterious effects of atmospheric pollution on human health are also known by increasing incidence and exacerbations of pre-existing lung diseases such as asthma. However, the effects of diesel exhausted particles (DEP) on acute allergic pulmonary inflammation during asthma sensitization process remain unclear.  Objective : To evaluate the effects of 5 weeks of DEP exposure during the sensitization process of acute allergic pulmonary inflammation in an experimental murine model.  Methods : Male Swiss mice were divided into 4 groups: non OVA-sensitized and saline instillation animals (10 µL/mouse) (Control, n=6), non OVA-sensitized and DEP instillation mice (3 mg/mL-10 µL/mouse) (DEP, n=8), OVA-sensitized and saline instillation animals (OVA, n=6) and OVA-sensitized and DEP instillation mice (DEP+OVA, n=8). 24 hours after OVA or saline aerosol challenge anesthetized mice were euthanized and was performed measures of inflammatory cells from bronchoalveolar fluid (BALF) and IL-4, IL-5, IL-1β, TNF-α and total immunoglobulin IgE levels from lung tissue by enzyme-linked immunosorbent assay.  Results : The coexposure to DEP resulted in an increase of eosinophils, neutrophils and lymphocytes in BALF (p Conclusion  :  In this experimental model, the effects of 5 weeks of DEP exposure on sensitization process resulted in an increase of leucocytes in BALF and cytokines levels in OVA group, suggesting that DEP exposure has an additional effect on lung inflammation in asthma.
PULMONARY EOSINOPHILIA ASSOCIATED WITH VASCULITIS AND EXTRA-VASCULAR GRANULOMATA.
Authors: J. L. BURTON, P. A. BURTON
Journal: British Journal of Dermatology (1972)

An unusual case of necrotizing vasculitis is reported, in which chronic bronchitis preceded the onset of “allergic” vasculitis of the skin, rhinitis, conjunctivitis, pulmonary infiltrates, marked blood eosinophilia and extra-vascular granulomatous proliferation. The case had features of both Churg's allergic granulomatosis and Wegener's granulomatosis, but it was typical of neither condition. The relationship between benign pulmonary eosinophilia, Churg's allergic granulomatosis and Wegener's granulomatosis is discussed, and it is suggested that intermediate cases of this type might be called Chegener's granulomatosis. A review of the literature suggests that the range of syndromes could be extended to include Chöffler's pulmonary eosinophilia, comprising cases transitional between Löffler's and Churg's syndromes. For the sake of brevity and onomatopoeia the Löffler-Chöffler-Churg-Chegener-Wegener syndromes could be linked together as the “Chöffler Train”.
RV568, a narrow spectrum kinase inhibitor (NSKI), inhibits virus induced nasal interleukin-8 (IL8) in the human viral challenge model where healthy adult male volunteers were experimentally inoculated with live respiratory syncytial virus
Authors: Lindsey Cass, Kazuhiro Ito, Catherine Charron, Pete Strong, Chantelle Norton, Anthony Gilbert, Rob Lambkin-Williams, Alex Mann, Garth Rapeport
Journal: European Respiratory Journal (2013)

RATIONALE   RV568 inhibits respiratory syncytial virus (RSV) induced IL8 release in nasal epithelial cells in vitro by targeting host cell signalling. The primary aim was to assess the effects of RV568 on nasal IL8 following inoculation with RSV Memphis 37 in human subjects and demonstrate translation of the preclinical data to support progression of RV568 in patients with respiratory disease.   METHODS    42 subjects aged 18–45 years were recruited into this randomised, single-blind, placebo-controlled, parallel-group quarantine study. RV568 (400µg) was administered intranasally twice daily from Day (D) -1 to 8 inclusive. Subjects were inoculated with RSV on D0 and remained in quarantine until D12. Nasal wash samples were collected daily, except for D0 and 1, for the assessment of IL8 (Luminex); secondary endpoints included nasal IL6, viral load (RT-PCR), infectivity rate, clinical symptoms and nasal secretion (tissue weight) in infected subjects.   RESULTS    71% of subjects (30/42) had laboratory confirmed RSV. There was a 46% inhibition of the mean area under the profile-time curve from D2 to 12 (AUC2-12) for IL8 in the RV568 group compared to placebo (p=0.07). There was no observed difference between the groups for IL6 (AUC2-12), viral load, infectivity, or clinical symptoms. For nasal secretion the mean AUC0-12 was 304.3 g/h in the RV568 group vs 107.5 g/h in the placebo group.   CONCLUSION   Using the RSV Human Viral Challenge Model subjects treated with RV568 reduced IL8 inflammatory response compared with placebo, consistent with preclinical findings.
Diagnostic yield of endobronchial cryobiopsy in central tumours with previous non-diagnostic conventional forceps biopsy
Authors: Maria del Valle Somiedo Gutierrez, Virginia Pajares Ruiz, Jose Sanz Santos, Alfons Torrego Fernández, Felipe Andreo Garcia, Laura López, Jose Luis Mate, Justina Szafranska, Vicente Moral Plaza, Juan Ruiz Manzano
Journal: European Respiratory Journal (2014)

AIM: Endobronchial cryobiopsy (EC) is a technique that obtains high quality specimens in patients with endobronchial tumours. The aim of our study was to evaluate the usefulness of EC in patients with a previous non-diagnostic sample obtained by means of conventional forceps biopsy (FB).

PATIENTS AND METHODS:We included patients with an endobronchial tumour and a previous non-diagnostic conventional FB who underwent EC in two institutions from 2009 to 2013. Patients characteristics, sample adequacy, final diagnoses and procedure complication rate were analyzed.

RESULTS:

14 patients were included (10 men) with a mean age of 65.57 yrs (SD 13.4). All patients had a previous non-diagnostic bronchoscopy (range 1-3). EC attained a histological diagnosis in 13 patients (92.8%). Minimum complications were recorded: one case of pneumotorax and a moderate endobronchial bleeding. The mean specimen area of the biopsies obtained by EC was significantly larger than those obtained by FB

View this table:

Sample characteristics





. The percentage of crush artefact was lower in biopsies obtainted by EC (difference statistically non-significant). The frozen of the sample did not interfere with the inmunohistochemical stainings or molecular techniques.

CONCLUSIONS:

EC obtained high quality samples that allowed histological diagnoses in most of the patients (92.8%) with a previous non-diagnostic FB. No fatal complications were recorded.
A phase II study of ABR-214936 (anatumomab mafenatox) tumour targeted superantigen (TTS) therapy in patients with advanced adenocarcinoma of the pancreas
Authors: N. B. Connolly, D. Shaw, J. Fenemore, C. Garner, S. Kilany, G. Hedlund, G. Forsberg, P. Stern, R. E. Hawkins
Journal: Journal of Clinical Oncology (2004)

3162 Tumour Targeted Superantigen therapy is a novel form of cancer therapy. The principle involves targeting the superantigen with subsequent activation of cytotoxic T cells in tumor tissue. ABR214936 is a recombinant fusion protein of a mutated Staphylococcal enterotoxin A and a Fab moiety recognising the oncofetal antigen 5T4 expressed in the majority of pancreas cancers. In this open non controlled phase II study pts with histologically confirmed pancreas adenocarcinoma, measurable disease and good PS are treated with a daily 3 hour infusion of ABR214936 for 4 consecutive days. Pre-formed circulating anti-SEA antibodies neutralise the effects of ABR-214936 and so dosing is adapted to the pre-existing antibody-titre. Each patient is treated with an individual dose based on the pre-treatment anti-SEA antibody concentration and adjusted to body weight. A second cycle is given 4–6 weeks later when the dose is adjusted to the new titre. Evaluation is by means of a pre treatment CT scan repeated at D56 and D112 to evaluate tumor response. Side effects include pyrexia, rigors, nausea, vomiting, and hypotension. If a drug-related AE SAE occured the dose for the next infusion is decreased to 75%, if a further reaction then reduced to 50%. Treatment is well tolerated with no withdrawns due to toxicity. Approximately 26% experienced a drug related AE most commonly grade 1- 2 pyrexia. 20 pts recruited, 12 had 2 cycles, 7 only 1, 1 withdrew consent. 18 had received gemcitabine based chemotherapy, 1 5FU and 1 RT. At D56 6 pts had SD, 7 PD and 7 had died. At D112 2 pts had SD. Both previously treated with gemcitabine chemotherapy. ABR214936 is a promising and active agent in this difficult to treat cancer. It has been demonstrated to be safe and well tolerated. Follow-up is ongoing. No significant financial relationships to disclose.
Exhaled nitric oxide in diagnosis and management of respiratory diseases
Authors: Eugerta Dilka, Armela Cuko, Dhimiter Argjiri, Roland Kore, Jeta Beli, Elenka Shehu, Eritjan Tashi, Edlira Ndreu, Esmeralda Nushi, Arben Tanku, Artan Simaku, Perlat Kapisyzi
Journal: European Respiratory Journal (2013)

Purpose of the study.  To study the values of FENO in respiratory diseases and the relationship with disease stage and pulmonary function tests.   Materials and Methods. This was a prospective study. FeNO has been measured in 111 patients: 41 with asthma, 3 GERD, 19 bronchiectasis, 11 sarcoidosis, 23 COPD, 14 secondary Pulmonary Hypertension. FeNO was measured by chemoluminescence using NIOX MINO, consistent with the ATS guidelines published in 2005.  We used t test and ANOVA. Significance was defined as a p value of    Results.  The mean of FENO in asthma was 30.5pp ±30.7SD with range 5 – 124. p=0.003. The mean of FENO was 91ppb in moderate stage, 80.5ppb in inttermitent, 63ppb in severe and 60ppb in mild stage.The mean of FENO in the asthma with normal value of IgE and high value of IgE were 15.8 ±13.4SD and 64.9 ±28.1SD respectively. P   Conclusions . The value of FeNO in asthma is not correlated with the values of FEV1 but with the activity of eosinophilic inflammation and atopy. There was significant change between the mean of FENO to the stages of COPD. There was negative moderate correlation between the value of FENO and PSAP.
Transplantation Behavior of Allotransplantable Tumor Lines Derived From Immunologically Modified Hosts2
Authors: Richard C. Parks, Barbara B. Jacobs
Journal: JNCI Journal of the National Cancer Institute (1975)

Journal Article Transplantation Behavior of Allotransplantable Tumor Lines Derived From Immunologically Modified Hosts Get access Richard C. Parks, Richard C. Parks Search for other works by this author on: Oxford Academic PubMed Google Scholar Barbara B. Jacobs Barbara B. Jacobs Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 54, Issue 5, May 1975, Pages 1079–1083, https://doi.org/10.1093/jnci/54.5.1079 Published: 01 May 1975 Article history Received: 05 August 1974 Revision received: 27 December 1974 Accepted: 21 January 1975 Published: 01 May 1975
Cell Culture of Three Antibody-Producing Murine Plasmacytomas
Authors: Phillip Periman
Journal: JNCI Journal of the National Cancer Institute (1971)

Three murine plasma cell tumors were adapted to grow in cell culture. In vitro each plasmacytoma cell line secreted Immunoglobulin of the same type and same antigenic reactivity found in the parent tumor. During the observation period, which for 1 line was over 24 months, only the same types of light and heavy chains found initially were secreted. All 3 cell lines retained the ability to produce immunoglobulin-secreting plasma cell tumors when inoculated into BALB/c mice.
The use of digitial devices to quantify air leak in pneumothorax
Authors: Georgia Tunnicliffe, Yee Ean Ong, Adrian Draper, Lucy Schomberg
Journal: European Respiratory Journal (2013)

Although spontaneous pneumothorax is a relatively common medical problem its management can be complex. Recently there has been increasing usage of digital systems within cardio-thoracic surgery to quantify air leaks and aid in clinical decision making regarding the removal of chest drains post-operatively. The literature suggests improved agreement between surgeons on timing of removal of chest drains, reduced length of stay of patients and an estimated saving of approximately €750 per patient. It could be that such devices could be useful tool in managing cases of pneumothorax.  Following ethics panel review, this pilot study recruited adults admitted with a pneumothorax requiring a chest drain. Participants had the underwater seal device changed for a digital device which allowed continuous monitoring of the air leak. Drains were removed when either there was no ongoing air leak and the lung had expanded, or surgery was deemed necessary.  8 patients with pneumothorax (2 primary, 6 secondary) had a digital drainage box during their admission. One patient who required prolonged suction was able to have this at home as the device has internal suction. Data was used to aid the clinician in management of the pneumothorax including the timing of surgery/ removal of drain and commencement of suction.  Digital devices appear to be safe and effective and may prove to be a useful tool in the management of pneumothorax.
Sclerosing perineuriomas affecting bilateral hands
Authors: H-Y. Huang, M-T. Sung
Journal: British Journal of Dermatology (2002)

Summary Sclerosing perineurioma is a rare, recently described variant of perineurioma that tends to affect the fingers and palms of adolescents or young adults. The process typically presents as a painless, well-circumscribed, unencapsulated nodule involving subcutis or reticular dermis. To our knowledge, all of the previously reported sclerosing perineuriomas were solitary. Hence, we report a 16-year-old boy, without stigmata of neurofibromatosis, who developed one sclerosing perineurioma in the right palm and another on the left index finger. Microscopically, tumours at both sites revealed small epithelioid and plump spindle cells with trabecular, whorled, or Indian file growth pattern enmeshed within extensively hyalinizing stroma. Immunohistochemically, the tumour cells showed strong reactivity for EMA but negative staining for S-100 and neurofilament. Ultrastructually, the tumour cells in both lesions exhibited features of perineurial cells, including discontinuous external basal lamina, occasional pinocytotic vesicles, and encirclement of abundant collagen fibrils by the interdigitating cytoplasmic processes. This case confirms the fact that sclerosing perineurioma is not always solitary.