tbuckley/cabot-search huggingface dataset:
Clinical Effectiveness in Allied Health Practices
Authors: Hannah L. Hedrick
Journal: JAMA (1994)

Although health system reform efforts have increased recognition of the important role of allied health care providers in organizing, financing, and delivering services in varied treatment settings, health services research has focused primarily on physicians, nurses, and, very recently, physician assistants. Lack of a comprehensive overview of the literature on the effectiveness of treatment provided by allied health professionals has impeded setting research priorities, undertaking effectiveness studies, and developing clinical practice guidelines.<i>Clinical Effectiveness in Allied Health Practices</i>is the first annotated bibliography of clinical effectiveness articles across multiple professions, and, although limited to physical therapy, respiratory care, and dietetics, it establishes a methodology that could be used to examine other allied health professions. The author has summarized critical analyses and evaluations of 328 articles prepared by a multidisciplinary team using 22 internal and external validity criteria. The reviewers targeted articles related to health services research, clinical effectiveness of the
Ultrasound guided injection of recalcitrant plantar fasciitis
Authors: D. Kane, T. Greaney, B. Bresnihan, R. Gibney, O. FitzGerald
Journal: Annals of the Rheumatic Diseases (1998)

To determine the effect of ultrasound guided injection in recalcitrant idiopathic plantar fasciitis.Four patients with a clinical diagnosis of idiopathic plantar fasciitis, who were unresponsive to palpation guided injection with triamcinolone acetonide and local anaesthetic, underwent ultrasonographic examination of the heel.The following ultrasonographic features were noted:- (a) increased thickness of plantar fascia in symptomatic heels compared with asymptomatic heels, (b) loss of distinction of the distal plantar fascia borders, (c) reduced echogenicity of the plantar fascia. Ultrasound guided injection of the enlarged, hypoechoic plantar fascia resulted in complete relief in four of five heels (mean duration of follow up = 24 months) in three cases. One patient developed a recurrence of symptoms after six months.Ultrasound allows for confirmation of the clinical diagnosis and ultrasound guided injection produces a good clinical response when unguided injection is unsuccessful. The technique is quick, inexpensive, and entails no radiation exposure.
US senator seeks information about medical faculty links to drug industry
Authors: J. H. Tanne
Journal: BMJ (2009)

Senator Chuck Grassley has asked 23 US medical schools for information about their policies on conflicts of interest and requirements for disclosure of financial ties between staff members and drug firms.

Senator Grassley, an Iowa Republican who is the leading minority member on the Senate Committee on Finance, wrote to 23 medical schools that had not completed a survey by the American Medical Student Association.

The senator is active in investigating ties between medical schools, leading doctors, …
Abstract 4195: Protein phosphatase PPM1G regulates protein translation and cell growth by dephosphorylating 4E-BP1
Authors: Jianyu Liu, Tianyan Gao
Journal: Cancer Research (2012)

Abstract Protein translation initiation is a tightly controlled process responding to nutrient availability and mitogen stimulation. Deregulation of translation initiation leads to tumor development and progression. Serving as one of the most important negative regulators of protein translation, 4E binding protein 1 (4E-BP1) binds to translation initiation factor 4E and inhibits cap-dependent translation in a phosphorylation-dependent manner. Hyperphosphorylation of 4E-BP1, which leads to inactivation of 4E-BP1, has been linked to human cancers with increased malignancy. While it has been demonstrated previously that the phosphosphorylation of 4E-BP1 is controlled by mTOR in the mTOR complex 1 (mTORC1), the mechanism underlying the dephosphorylation of 4E-BP1 remains elusive. Here, we report the identification of PPM1G as the phosphatase of 4E-BP1 through an shRNA library screen of Ser/Thr protein phosphatases. Co-immunoprecipitation experiment reveals that PPM1G binds to 4E-BP1 in cells, and purified PPM1G dephosphorylates 4E-BP1 in vitro. Knockdown of PPM1G in 293E and colon cancer HCT116 and SW480 cells results in an increase in the phosphorylation of 4E-BP1 at both Thr37/46 and Ser65 sites. This PPM1G-mediated dephosphorylation of 4E-BP1 is specific as the phosphorylation of upstream regulators of 4E-BP1 including Akt and mTOR is not altered in PPM1G knockdown cells. Furthermore, the time course of 4E-BP1 dephosphorylation induced by amino acid starvation or mTOR inhibitor treatment is significantly slowed down in PPM1G knockdown cells. Functionally, the amount of 4E-BP1 bound to the cap-dependent translation initiation complex is decreased when expression of PPM1G is depleted. As the result, the rate of cap-dependent translation, cell size, and protein content are increased in PPM1G knockdown cells. Taken together, our study has identified protein phosphatase PPM1G as a novel regulator of protein translation by negatively controlling the phosphorylation of 4E-BP1. Thus, PPM1G may serve as a tumor suppressor by directly counteracting mTOR to inhibit cell growth in cancer. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 103rd Annual Meeting of the American Association for Cancer Research; 2012 Mar 31-Apr 4; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2012;72(8 Suppl):Abstract nr 4195. doi:1538-7445.AM2012-4195
REMOVAL OF WORM (FILARIA LOA) FROM THE EYE
Authors: R. H. Elliot
Journal: BMJ (1918)

PILARIA FROM THE} EYE.[MAY 4, 19I8 ordinary remedies, including prolonged rest in bed (the most important of all), should receive a fair trial, but in view of the injurious effect produced on the cortical cells by prolonged soaking in superfluous fluid, operative measures should not be unduly delayed.I would suggest three months as a fair probationary period.
Congenital Absence of the Pulmonary Valve
Authors: LUCIEN A. CAMPEAU, PAUL E. RUBLE, WARREN B. COOKSEY
Journal: Circulation (1957)

The autopsy on a 32-year-old man revealed an absence of the pulmonary valve, a ventricular septal defect, and a single coronary artery. Congenital absence of the pulmonary valve has not been previously reported. The diagnosis of the accompanying pulmonary incompetence is discussed in the light of the catheterization studies and clinical findings. The pathologic abnormalities as found at postmortem examination are described and the embryologic basis for the several congenital malformations found in this unusual case are discussed.
Re: Firas Abdollah, Maxine Sun, Jan Schmitges, et al. Cancer-Specific and Other-Cause Mortality After Radical Prostatectomy Versus Observation in Patients with Prostate Cancer: Competing-Risks Analysis of a Large North American Population-Based Cohort. Eur Urol 2011;60:920–30
Authors: Michael Froehner
Journal: European Urology (2011)
Male Criminals With Organic Brain Syndrome: Two Distinct Types Based on Age at First Arrest
Authors: Emily R. Grekin, Patricia A. Brennan, Sheilagh Hodgins, Sarnoff A. Mednick
Journal: American Journal of Psychiatry (2001)

OBJECTIVE: This study examined whether criminals with organic brain syndrome could be divided into two distinct types. The authors proposed that early starters (onset of criminal activity by age 18) would display a persistent, long-lasting pattern of deviance that was largely independent of their brain disorder, whereas late starters (onset at age 19 or after) would exhibit deviant behaviors that began late in life and were more directly related to their brain disorder. METHOD: Subjects were 1,130 male criminal offenders drawn from a birth cohort of all individuals born between January 1, 1944, and December 31, 1947, in Denmark. The main study group included all men with both a history of criminal arrest and a hospitalization for organic brain syndrome (N=565). In addition, for a subset of analyses, the authors examined a randomly selected, same-size comparison group of men with a history of criminal arrest who were not hospitalized for organic brain syndrome. Data were available on all arrests and all psychiatric hospitalizations for individuals in this cohort through the age of 44. RESULTS: Among those with organic brain syndrome, early starters were significantly more likely than late starters to 1) be arrested before the onset of organic brain syndrome, 2) show a higher rate of offending before but not after the onset of organic brain syndrome, 3) be both recidivists and violent recidivists, and 4) have a diagnosis of antisocial personality disorder. CONCLUSIONS: Male criminals with organic brain syndrome can be meaningfully divided into two distinct types on the basis of age at first arrest. Early starters show a more global, persistent, and stable pattern of offending than late starters. These results have implications for treatment and risk assessment.
The effectiveness of five strategies for the prevention of gastrointestinal toxicity induced by non-steroidal anti-inflammatory drugs: systematic review
Authors: Lee Hooper, Tamara J Brown, Rachel Elliott, Katherine Payne, Chris Roberts, Deborah Symmons
Journal: BMJ (2004)

<h3>Background</h3> Limited knowledge exists of parents’ perceptions and experiences of children’s hospices and how these contribute to the varied access and uptake of services. <h3>Aim</h3> This study aimed to explore parents’ perspectives and experiences of a hospice, to understand the barriers and/or facilitators to accessing a hospice, and what characteristics parents wanted from hospice provision. <h3>Methods</h3> A two-phase qualitative study underpinned by a constructivist grounded theory methodology was employed. Phase 1 used focus groups to collect data from parents of children already accessing the hospice (n=24). Phase 2 used in-depth semistructured interviews with parents of children who did not use the hospice (n=7) and with parents who had previous experience of using a hospice (n=7). <h3>Results</h3> A grounded theory of place bonding was developed which illustrates the cognitive journey taken by parents of children with life-limiting conditions considering/receiving hospice care for their child. <h3>Conclusions</h3> Finding a place where they belonged and felt at ‘home’ made the decision to accept help in caring for their child with a life-limiting condition more acceptable. The theory of place bonding offers children’s hospices a new perspective from which to view how parents access, accept and build relationships at the hospice.
New Zealand doctors criticise manslaughter law
Authors: C Essex
Journal: BMJ (1994)

The New Zealand Medical Association has petitioned the minister of justice to change the law relating to manslaughter. Section 155 of the Crimes Act 1961 does not differentiate between an anaesthetist whose patient died after an anaesthetic error and a man who caused the death of a doctor whose home he was robbing in an attempt to obtain drugs. Both men were charged with manslaughter. The medical association argues …
An Amish House Call
Authors: Raymond D. Hobbs
Journal: Annals of Internal Medicine (2000)

On Being a Doctor21 November 2000An Amish House CallRaymond D. Hobbs, MDRaymond D. Hobbs, MDDr. Hobbs: Oakwood Hospital; Dearborn, MI 48124Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-133-10-200011210-00018 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail Making house calls was exhausting. It was late afternoon, time for the Sunday meal, and he was dead tired. Fortunately, these were familiar back roads in the county where he had practiced for many years, and there was only one more name on the list. He glanced briefly at the note. It gave the address of a woman who needed a vitamin B12 shot. He found the house, well known to him from previous visits, pulled the car into the driveway, parked it, got out, and went to the side door. The family was sitting at the table, about to ... Author, Article, and Disclosure InformationAffiliations: Dr. Hobbs: Oakwood Hospital; Dearborn, MI 48124Corresponding Author: Raymond D. Hobbs, MD, 3319 River Pines, Ann Arbor, MI 48103; e-mail, [email protected]com. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 21 November 2000Volume 133, Issue 10Page: 834-836KeywordsBronchitisMilkPneumoniaResidencyRiversRunningSmellSweatThermometersThorax ePublished: 21 November 2000 Issue Published: 21 November 2000 Copyright & PermissionsCopyright © 2000 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
hnRNP A2 Regulates Alternative mRNA Splicing of TP53INP2 to Control Invasive Cell Migration
Authors: Kim Moran-Jones, Joan Grindlay, Marc Jones, Ross Smith, Jim C. Norman
Journal: Cancer Research (2009)

Abstract Largely owing to widespread deployment of microarray analysis, many of the transcriptional events associated with invasive cell migration are becoming clear. However, the transcriptional drives to invasive migration are likely modified by alternative splicing of pre-mRNAs to produce functionally distinct patterns of protein expression. Heterogenous nuclear ribonucleoprotein (hnRNP A2) is a known regulator of alternative splicing that is upregulated in a number of invasive cancer types. Here, we report that although siRNA of hnRNP A2 had little influence on the ability of cells to migrate on plastic surfaces, the splicing regulator was clearly required for cells to move effectively on three-dimensional matrices and to invade into plugs of extracellular matrix proteins. We used exon-tiling microarrays to determine that hnRNP A2 controlled approximately six individual splicing events in a three-dimensional matrix-dependent fashion, one of which influenced invasive migration. Here, we show that alternative splicing of an exon in the 5′ untranslated region of a gene termed TP53INP2 is a key event downstream of hnRNP A2 that is necessary for cells to invade the extracellular matrix. Furthermore, we report that the consequences of altered TP53INP2 splicing on invasion are likely mediated via alterations in Golgi complex integrity during migration on three-dimensional matrices. [Cancer Res 2009;69(24):9219–27]
Mechanism of decreased myocardial contractile force after epicardiectomy
Authors: M. P. Kaye, W. C. Randall
Journal: Cardiovascular Research (1970)

Journal Article Mechanism of decreased myocardial contractile force after epicardiectomy Get access Michael P. Kaye, Michael P. Kaye From the Departments of Surgery and Physiology, Loyola University Medical Centre and Research Service, Hines Veterans Administration Hospital, Maywood, Illinois, U.S.A. Search for other works by this author on: Oxford Academic PubMed Google Scholar Walter C. Randall Walter C. Randall From the Departments of Surgery and Physiology, Loyola University Medical Centre and Research Service, Hines Veterans Administration Hospital, Maywood, Illinois, U.S.A. Search for other works by this author on: Oxford Academic PubMed Google Scholar Cardiovascular Research, Volume 4, Issue 2, April 1970, Pages 154–159, https://doi.org/10.1093/cvr/4.2.154 Published: 01 April 1970 Article history Accepted: 05 November 1969 Published: 01 April 1970
Adult-Onset Autoimmune Diabetes in Europe Is Prevalent With a Broad Clinical Phenotype
Authors: Mohammed I. Hawa, Hubert Kolb, Nanette Schloot, Huriya Beyan, Stavroula A. Paschou, Raffaella Buzzetti, Didac Mauricio, Alberto De Leiva, Knud Yderstraede, Henning Beck-Neilsen, Jaakko Tuomilehto, Cinzia Sarti, Charles Thivolet, David Hadden, Steven Hunter, Guntram Schernthaner, Werner A. Scherbaum, Rhys Williams, Sinead Brophy, Paolo Pozzilli, Richard David Leslie
Journal: Diabetes Care (2012)

Specific autoantibodies characterize type 1 diabetes in childhood but are also found in adult-onset diabetes, even when initially non-insulin requiring, e.g., with latent autoimmune diabetes (LADA). We aimed to characterize adult-onset autoimmune diabetes.
Stroke Care Within the Golden Hour—Reply
Authors: Martin Ebinger, Heinrich J. Audebert
Journal: JAMA Neurology (2015)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Neurology HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Neurology journal
Margaret McCartney: Cancer strategy should be led by evidence
Authors: M. McCartney
Journal: BMJ (2015)

Harpal Kumar, chief executive of the charity Cancer Research UK (CRUK), is to chair the new Cancer Strategy Taskforce, which will promote “swifter diagnosis.”1 Who could argue with that? Well, I have some concerns. 

GPs are in an invidious position. Few symptoms, conceivably, could never represent cancer. Referring every patient with any symptom for further tests would do enormous harm to the over-investigated population—and to the people whose worrying symptoms are investigated less swiftly because of the waiting list that GPs have created.

New draft guidelines from the National Institute for Health and Care Excellence (NICE) recommend lowering the bar so that patients are referred for further investigations when their calculated risk of cancer reaches 3%.2 NICE also proposes less sensitive tests. So, for example, it …
Prenatal screening for congenital heart disease.
Authors: L D Allan, D C Crawford, S K Chita, M J Tynan
Journal: BMJ (1986)

Routine ultrasound examination of the fetus is already established in most obstetric units in Britain. A simple method was devised to evaluate one section of the fetal heart systematically. Examination of this section, the four chamber view, may readily be incorporated into routine obstetric screening. Severe cardiac abnormalities detectable in this view occur in two per 1000 pregnancies. For six years the department of paediatric cardiology at Guy9s Hospital, London, served as a referral centre for fetal echocardiography. As teaching became more widespread an increasing proportion of cases of cardiac anomaly were referred because the obstetrician suspected abnormality on examination of the four chamber view. Currently 80% of detected abnormalities are referred for this reason. Further extension and organisation of teaching might result in most severe cardiac malformations being detected in early prenatal life.
Stress Fracture of the First Rib in a Weightlifter
Authors: John Eng, James Westcott, Nathan Better
Journal: Clinical Nuclear Medicine (2008)

A 20-year-old woman elite weightlifter presented with acute onset debilitating right shoulder pain while attempting the "clean and jerk." There was no previous relevant history, including no prior fracture in the region. Examination confirmed vague tenderness in the right supraclavicular fossa with no discernible neurologic or vascular deficit within the right arm. X-ray was normal. The patient had a bone scan, including SPECT, suggesting a fracture of the right first rib, subsequently confirmed on CT examination.
Causes of failure and pathologic findings in surgically removed Ionescu-Shiley standard bovine pericardial heart valve bioprostheses: emphasis on progressive structural deterioration.
Authors: F J Schoen, J Fernandez, L Gonzalez-Lavin, A Cernaianu
Journal: Circulation (1987)

Twenty-three Ionescu-Shiley standard bovine pericardial bioprostheses (15 aortic, seven mitral, and one tricuspid) removed at surgery from 21 adults, 28 to 75 years old (mean 55 at reoperation), were examined after functioning for as long as 84 months (mean 26). Reoperation was necessitated by active or healed endocarditis (10 valves), paravalvular leak (three), structural deterioration (eight), and other causes (two). Valves with degenerative dysfunction functioned 32 to 84 months (mean 68). Six had intrinsic cuspal calcification, one with stenosis, and there was regurgitation through secondary cuspal defects in five. Six valves had cuspal defects clearly associated with commissural sutures ("alignment stitches") unique to this valve design. One valve had a large basal cuspal tear. Other prominent pathologic features included gross cuspal thickening and mild stretching and microscopic deep fluid insudation, separation of collagen bundles, and mononuclear inflammation. Thus, structural disruption due to calcific tissue degeneration and design-related cuspal tears or commissural perforations are the predominant modes of degenerative failure of Ionescu-Shiley standard bovine pericardial valves.
Case 20-1962
Authors: John W. Keller
Journal: New England Journal of Medicine (1962)

Presentation of CaseA seventy-four-year-old woman entered the hospital because of weakness.Increasing fatigue began several months previously, and two weeks before admission weakness, malaise and anorexia developed, with intermittent elevation of the temperature to 101°F. The patient also experienced episodes of epistaxis, as well as severe, diffuse back pain, migratory pain in the joints, especially the wrists and elbows, and pain and swelling of the right fifth metacarpophalangeal joint. Penicillin was given for three days, without relief of symptoms.Mild arthritic symptoms had been present for many years. She had had numbness, weakness and pallor of the hands after . . .
SERIAL CHANGES OF NEOINTIMAL COVERAGE CHARACTERISTICS IN 4 KINDS OF DRUG-ELUTING STENTS: OPTICAL COHERENCE TOMOGRAPHY STUDY
Authors: Daisuke Nakamura, Masami Nishino, Takahiro Yoshimura, Yasuharu Lee, Masayuki Taniike, Hiroyasu Kato, Yasuyuki Egami, Jun Tanouchi, Yoshio Yamada
Journal: Journal of the American College of Cardiology (2012)