tbuckley/cabot-search huggingface dataset:
Ageing Styles: Subjective Well-Being and Somatic Complaints in Inpatients Aged ≥60 Years
Authors: Gudrun Schneider, Georg Driesch, Andreas Kruse, Michael Wachter, Hans-Georg Nehen, Gereon Heuft
Journal: Psychotherapy and Psychosomatics (2003)

&lt;i&gt;Background:&lt;/i&gt; Recent gerontological research shows a high variability in the elderly population. The aim of the present study is to investigate by means of cluster analysis, as to whether different ‘ageing styles’ can be identified in a sample of cognitively not impaired older persons, and to assess discrepancies between self-rated and expert-rated psychological and physical health. &lt;i&gt;Method:&lt;/i&gt; 243 patients aged 60 years and older in a general hospital were investigated using a clinical psychiatric interview, expert ratings, and self-report scales after extensive internal medical diagnostic evaluation. &lt;i&gt;Results:&lt;/i&gt; Five clusters, representing significantly different ‘ageing styles’ with regard to subjective well-being and subjective physical complaints, could be identified. Two clusters, which together constituted 57% of the sample, represented quite positive and desirable ageing styles. In two clusters (altogether 23% of the sample), there was a discrepancy between medical findings and subjective physical complaints. &lt;i&gt;Conclusions:&lt;/i&gt; These findings support the notion of high variability in the elderly and the existence of subgroups, which show a discrepancy between subjective assessment of well-being and expert assessment of psychological and physical health and impairment. The recording of subjectively perceived physical complaints should, therefore, be part of the evaluation of older peoples’ subjective well-being.
Sequential erythema nodosum leprosum and reversal reaction with similar lesional cytokine mRNA patterns in a borderline leprosy patient
Authors: M.O. Moraes, E.P. Sampaio, J.A.C. Nery, B.C.C. Saraiva, F.B.F. Alvarenga, E.N. Sarno
Journal: British Journal of Dermatology (2001)

We compare the clinical and histological data with the immunological status of a borderline leprosy patient who experienced an erythema nodosum leprosum (ENL) reaction followed by a reversal reaction (RR) after 12 weeks of anti-inflammatory treatment (pentoxifylline, PTX, 1200 mg daily). Skin biopsies, serum and blood samples were collected sequentially during the reactional episodes. At the outset of RR, the patient's lymphocytes secreted interferon (IFN) -gamma and there was a positive lymphoproliferative test in response to Mycobacterium leprae, which had been absent during ENL. The lepromin reaction reversed from negative (0 mm) at diagnosis, to positive (3 mm) 3 months after the development of RR. Tumour necrosis factor (TNF) -alpha levels in the serum decreased after 1 week of treatment and increased slightly thereafter. The immunohistochemical data for ENL showed a diffuse dermal and hypodermal infiltrate composed of mononuclear cells and neutrophils, while RR was characterized by an epithelioid granulomatous infiltrate with a marked presence of gammadelta T cells. Reverse transcription-polymerase chain reaction showed a mixed cytokine profile characterized by the expression of TNF-alpha, IFN-gamma, interleukin (IL) -6, IL-10 and IL-12 mRNA in the skin, which persisted throughout the development of ENL and RR lesions. IL-4 mRNA, first detected after 7 days of PTX treatment, was still present during RR. The results suggest the emergence of an initial Th0-like cytokine profile in ENL, typical of a state of immunoactivation, before conditions optimal for the appearance of an antigen-specific cell-mediated immune response and gammadelta T-cell migration are created.
The cutaneous lesions of systemic and chronic discoid lupus erythematosus and porphyria symptomatica in the same patient.
Authors: Walter Gordon
Journal: British Journal of Dermatology (1966)

Journal Article The cutaneous lesions of systemic and chronic discoid lupus erythematosus and porphyria symptomatica in the same patient. Get access Walter Gordon Walter Gordon Groote Schuur Hospital, Observatory, Cape, South Africa Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 78, Issue 1, 1 January 1966, Pages 53–54, https://doi.org/10.1111/j.1365-2133.1966.tb12134.x Published: 01 January 1966
ABC of labour care: Operative delivery
Authors: G. Chamberlain, P. Steer
Journal: BMJ (1999)

In Britain all operative deliveries are now performed in a hospital. Caesarean sections must take place in hospital, but the National Birthday Trust's 1994 survey of home births reported that all ventouse and low forceps deliveries also took place in hospital (Chamberlain, 1997). However, not only obstetricians have to know about these deliveries—general practitioners and midwives need to know too, so that they can brief women and prepare to deal with any complications that may arise. View this table: NHS hospital deliveries England, 1980-94 (from NHS Maternity Statistics England, 1997) An operative delivery is performed if a spontaneous birth is judged to pose a greater risk to mother or child than an assisted one. Operations are divided into abdominal methods (caesarean section) and vaginal assisted deliveries (forceps delivery and vacuum extraction). ### Preparations for operative delivery ### Indications for caesarean section
Progress in Ophthalmic Surgery
Authors: John H. Dunnington, Ellen F. Regan, Francis A. L'Esperance
Journal: New England Journal of Medicine (1963)

IN all surgical fields progress is so gradual that it is always difficult to pinpoint its causes. More precise preoperative diagnosis, better anesthesia, improved surgical technic and finer instrumentation all contribute to this progress. Ophthalmic surgery has benefited through each of these channels. For example, more precise preoperative diagnosis has been a major factor in improving the results of retinal-detachment surgery. On the other hand, in keratoplasty and cataract extraction, better instrumentation has played a more important part. Adequate preoperative sedation, combined with complete akinesia, and retrobulbar anesthesia are safeguards used in most ophthalmic surgery. The present status of the . . .
LRIG1 Modulates Cancer Cell Sensitivity to Smac Mimetics by Regulating TNFα Expression and Receptor Tyrosine Kinase Signaling
Authors: Longchuan Bai, Donna McEachern, Chao-Yie Yang, Jianfeng Lu, Haiying Sun, Shaomeng Wang
Journal: Cancer Research (2012)

Smac mimetics block inhibitor of apoptosis proteins to trigger TNFα-dependent apoptosis in cancer cells. However, only a small subset of cancer cells seem to be sensitive to Smac mimetics and even sensitive cells can develop resistance. Herein, we elucidated mechanisms underlying the intrinsic and acquired resistance of cancer cells to Smac mimetics. In vitro and in vivo investigations revealed that the expression of the cell surface protein LRIG1, a negative regulator of receptor tyrosine kinases (RTK), is downregulated in resistant derivatives of breast cancer cells sensitive to Smac mimetics. RNA interference-mediated downregulation of LRIG1 markedly attenuated the growth inhibitory activity of the Smac mimetic SM-164 in drug-sensitive breast and ovarian cancer cells. Furthermore, LRIG1 downregulation attenuated TNFα gene expression induced by Smac mimetics and increased the activity of multiple RTKs, including c-Met and Ron. The multitargeted tyrosine kinase inhibitors Crizotinib and GSK1363089 greatly enhanced the anticancer activity of SM-164 in all resistant cell derivatives, with the combination of SM-164 and GSK1363089 also completely inhibiting the outgrowth of resistant tumors in vivo. Together, our findings show that both upregulation of RTK signaling and attenuated TNFα expression caused by LRIG1 downregulation confers resistance to Smac mimetics, with implications for a rational combination strategy.
Distribution of Cancers of the Large Bowel-Reply
Authors: James B. Rhodes
Journal: JAMA (1978)

It distresses us that Dr Prager is concerned that we or the readers might think that rectal palpation and sigmoidoscopy are no longer helpful in the diagnosis of large bowel cancer. These examinations remain important in the diagnosis of rectal and rectosigmoid cancer. These cancers are still common, as noted in Table 1 and Fig 2 in our article. Our purpose was to point out that rectal and rectosigmoid cancers account for a decreasing percentage of large bowel cancers and that other methods are required to detect the increasing percentage of colon cancers that occur higher up. This appears to be his experience. The possibility that rectal polypectomy may be a factor in decreasing percentage of rectal and rectosigmoid cancers is of interest. We have no data on this possibility.
Diseases of the Liver
Authors: Frank L. Iber
Journal: JAMA (1982)

This book, currently in its fifth edition, continues the tradition of excellent topical monographs in the field of liver pathophysiology and diseases, written by the finest authors available. Dr Leon Schiff has been joined by his son Eugene as editor, and another son, Gilbert, has contributed one of the chapters. The book consists of 42 chapters from six to 70 pages in length. Each is a complete monograph unto itself, written for the clinical hepatologist with heavy emphasis on pathophysiology. About 15 of the chapters are a modest update of excellent works from previous editions, but the majority are completely new, indicating the major changes in the liver field. Outstanding reviews include the chapters "Hormones and Liver Function," "Viral Hepatitis," "Toxic and Drug-Induced Hepatitis," "Influence of Liver Diseases on the Disposition and Elimination of Drugs," "Chronic Hepatitis," and "Special Radiological Procedures in Liver Diseases." These represent the state of the
The Dancing Neurologist
Authors: George N. Braman
Journal: Annals of Internal Medicine (1999)

Ad Libitum20 April 1999The Dancing NeurologistGeorge N. Braman, MDGeorge N. Braman, MDBronx, NY 10471 (Braman)Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-130-8-199904200-00006 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail The dancing neurologist pleases me—He sails the calm Aegean every Spring—Like Sophocles, he contemplates the seaAnd treats our cares as a diminished thing.Such fancy footwork is a gracious gift—To shift attention's locus to the feetAnd let the mind's free concentration driftTo this rhythmic swaying Ionic beat.In such a state, what relics from the past,What precious driftwood casually afloatMight rise to fevered consciousness at lastOr slip into the gently rocking boat?What jealous gods or goddesses might seizeThe dancing neurologist's reveries? Author, Article, and Disclosure InformationAuthors: George N. Braman, MDAffiliations: Bronx, NY 10471 (Braman)Corresponding Author: George N. Braman, MD, 6142 Delafield Avenue, Bronx, NY 10471. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 20 April 1999Volume 130, Issue 8 Page: 699 Keywords Attention Consciousness ePublished: 15 August 2000 Issue Published: 20 April 1999 Copyright & PermissionsCopyright © 1999 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Incidence and natural history of challenge‐proven cow's milk allergy in European children – EuroPrevall birth cohort
Authors: A. A. Schoemaker, A. B. Sprikkelman, K. E. Grimshaw, G. Roberts, L. Grabenhenrich, L. Rosenfeld, S. Siegert, R. Dubakiene, O. Rudzeviciene, M. Reche, A. Fiandor, N. G. Papadopoulos, A. Malamitsi‐Puchner, A. Fiocchi, L. Dahdah, S. Th. Sigurdardottir, M. Clausen, A. Stańczyk‐Przyłuska, K. Zeman, E. N. C. Mills, D. McBride, T. Keil, K. Beyer
Journal: Allergy (2015)

Cow's milk allergy (CMA) is one of the most commonly reported childhood food problems. Community-based incidence and prevalence estimates vary widely, due to possible misinterpretations of presumed reactions to milk and differences in study design, particularly diagnostic criteria.Children from the EuroPrevall birth cohort in 9 European countries with symptoms possibly related to CMA were invited for clinical evaluation including cows' milk-specific IgE antibodies (IgE), skin prick test (SPT) reactivity and double-blind, placebo-controlled food challenge.Across Europe, 12 049 children were enrolled, and 9336 (77.5%) were followed up to 2 years of age. CMA was suspected in 358 children and confirmed in 55 resulting in an overall incidence of challenge-proven CMA of 0.54% (95% CI 0.41-0.70). National incidences ranged from 1% (in the Netherlands and UK) to <0.3% (in Lithuania, Germany and Greece). Of all children with CMA, 23.6% had no cow's milk-specific IgE in serum, especially those from UK, the Netherlands, Poland and Italy. Of children with CMA who were re-evaluated one year after diagnosis, 69% (22/32) tolerated cow's milk, including all children with non-IgE-associated CMA and 57% of those children with IgE-associated CMA.This unique pan-European birth cohort study using the gold standard diagnostic procedure for food allergies confirmed challenge-proven CMA in <1% of children up to age 2. Affected infants without detectable specific antibodies to cow's milk were very likely to tolerate cow's milk one year after diagnosis, whereas only half of those with specific antibodies in serum 'outgrew' their disease so soon.
Hypocalciuria in Preeclampsia
Authors: J G Rodríguez, R Avendaño, B Inzunza
Journal: New England Journal of Medicine (1987)

Recent studies have associated preeclampsia with hypocalciuria, nevertheless others do not show association. We proposed to determinate if this association exists, so we studied 25 term pregnancies patients (13 normotensives, 7 transient hypertension and 5 preeclamptic). We did not find significative differences in the hematocrit, serum calcium, serum creatinine, platelets count and the 24 hour diuresis between these groups. The serum uric acid was significative lower in the normotensive group (3.5 +/- 0.8 mg/dl) than in the preeclamptic group (4.9 +/- 0.89 mg/dl) (mean +/- SD) (p < 0.05). The 24 hour calciuria was lower in the preeclamptic group (121 +/- 78 mg/24 hours) than in the normotensive (256 +/- 71 mg/24 hours) and transient hypertension group (229 +/- 93 mg/24 hours) (p < 0.05). We measured the creatinine clearance and the fractional excretion of calcium in the transient hypertension and the preeclamptic groups, there was significative difference only in the fractional excretion of calcium (2.5 +/- 0.8% and 1.1 +/- 0.8% respectively) (p < 0.05). All the patients had a good clinical evolution, so the arterial pressure returned to normal values in a mean period within 7 days in both groups. There were 3 newborn who were small for gestational age (1 in the transient hypertension and 2 in the preeclamptic group). The difference we found in the 24 hour calciuria and the fractional excretion of calcium agree with the finds of other authors, further prospective studies are needed to understand the physiology and pathophysiology of calcium metabolism in normal, transient hypertension and preeclamptic pregnancy.
Unchecked thrombin is bad news for troubled arteries
Authors: Eric Camerer
Journal: Journal of Clinical Investigation (2007)

Thrombin is clearly a key trigger of thrombosis, the proximal cause of most morbidity and mortality in atherosclerotic cardiovascular disease. Might thrombin also contribute to longer-term, structural changes in the arterial wall that promote narrowing and clotting? A study in this issue of the JCI argues that it can. Aihara et al. report that haploinsufficiency of heparin cofactor II, a glycosaminoglycan-dependent thrombin inhibitor, exacerbates injury- or hyperlipidemia-induced arterial lesion formation in mice, possibly by excessive thrombin signaling through protease-activated receptors (see the related article beginning on page 1514).
Cutaneous Squamous-Cell Carcinoma in Patients Treated with PUVA
Authors: Robert S. Stern, Nan Laird, John Melski, John A. Parrish, Thomas B. Fitzpatrick, Howard L. Bleich
Journal: New England Journal of Medicine (1984)

A 5.7-year prospective study of 1380 patients treated for psoriasis with oral methoxsalen (8-methoxypsoralen) and ultraviolet A photochemotherapy (PUVA) revealed that after adjustment for exposures to ionizing radiation and topical tar preparations, the risk that cutaneous squamous-cell carcinoma would develop at least 22 months after the first exposure to PUVA was 12.8 times higher in patients exposed to a high dose than in those exposed to a low dose (95 per cent confidence interval, 5.8 to 28.5). No substantial dose-related increase was noted for basal-cell carcinoma. The dose-dependent risk of cutaneous squamous-cell carcinoma suggests that PUVA can act as an independent carcinogen. In our study, morbidity associated with these tumors has been limited, but further follow-up is needed. Meanwhile, patients treated with PUVA should be followed closely for the possible development of cutaneous squamous-cell carcinoma.
Baseline Plasma Proteomic Analysis to Identify Biomarkers that Predict Radiation-Induced Lung Toxicity in Patients Receiving Radiation for Non-small Cell Lung Cancer
Authors: Xu-Wei Cai, Kerby A. Shedden, Shang-Hu Yuan, Mary A. Davis, Lu-Ying Xu, Cong-Ying Xie, Xiao-Long Fu, Theodore S. Lawrence, David M. Lubman, Feng-Ming (Spring) Kong
Journal: Journal of Thoracic Oncology (2011)
Abstract 1707: Establishment and characterization of pemetrexed-resistant lung cancer cell lines
Authors: Dan Zhang, Nobuaki Ochi, Nagio Takigawa, Yanyan Chen, Yasushi Tanimoto, Eiki Ichihara, Katsuyuki Hotta, Masahiro Tabata, Mitsune Tanimoto, Katsuyuki Kiura
Journal: Cancer Research (2011)

Abstract Purpose: Pemetrexed (PEM), a multitargeted antifolate with manageable toxicity, is a most active drug against non-squamous non-small cell lung cancer (NSCLC); however, a majority of patients acquired the resistance to PEM eventually. To elucidate the mechanisms of acquired resistance to PEM, we established eight PEM-resistant NSCLC cell lines. Method: PC-9 and A549 cells (adenocarcinoma of the lung) were treated with step-wise increasing concentrations of PEM. Sublines, which were able to grow in the presence of low and high concentrations of PEM, were cloned with limiting dilutions and designated PC-9/PEML and PC-9/PEMH, respectively; A549/PEML and A549/PEMH, respectively. Growth inhibition was defined by MTT assay. Thymidylate synthase (TS), dihydrofolate reductase (DHFR), glycinamide ribonucleotide formyltransferase (GARFT) and multidrug resistance-associated protein 4 (MRP4) gene expressions and protein expressions were analyzed by quantitative reverse transcriptase PCR and immunoblotting. Result:Characteristics of PEM-resistant sublines are shown in the Table. All resistant sublines showed cross-resistant to cisplatin but not to docetaxel, vinorelbine, 5-fluorouracil and the active metabolite of irinotecan (SN-38). TS mRNA expression was significantly increased in all resistant sublines compared to the parent cells. TS mRNA expression was paralleled to the increment of TS protein. DHFR was significantly increased in the PEM-resistant A549 sublines. GARFT was not correlated with resistance to PEM. MRP4 was increased in PC-9/PEMH and A549/PEMH sublines. Conclusions: PEM-resistant NSCLC may be still sensitive to docetaxel, vinorelbine, 5-fluorouracil and irinotecan. High TS expression seems to be the primary resistant mechanism to PEM. MRP4 and DHFR expression might be elevated at higher resistance to PEM. Relative resistance (R.R.) was defined as the ratio of 50% inhibitory concentration (IC50) of resistant cells to IC50 of parent cells; *p&amp;lt;0.05; **p&amp;lt;0.01. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 102nd Annual Meeting of the American Association for Cancer Research; 2011 Apr 2-6; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2011;71(8 Suppl):Abstract nr 1707. doi:10.1158/1538-7445.AM2011-1707
Cancer chemotherapy: new strategies for success.
Authors: N A Berger
Journal: Journal of Clinical Investigation (1986)

use of methotrexate to treat patients with choriocarcinoma demonstrated the important principle, in humans, that systemic chemotherapy could be used to destroy the neoplasm yet spare the patient (1). With the development ofnew chemotherapeutic agents, new strategies for their administration and combination, and more effective approaches to supportive care, it has become possible to cure patients with acute lymphoblastic leukemia (ALL),' Hodgkin's disease, diffuse histiocytic lymphoma, Burkitt's lymphoma, testicular cancer, Wilms' tumor, embryonal rhabdomyosarcoma, and Ewing's sarcoma (2, 3). Chemotherapy can also be used to achieve significant tumor regression and improve survival in patients with breast, gastric, prostatic, ovarian, and small cell lung cancers as well as for those with acute and chronic myelogenous leukemia and soft tissue sarcomas (2, 3).
Effect of medium pH on glutathione redox cycle in cultured human umbilical vein endothelial cells
Authors: Motoyoshi Ikebuchi, Atsunori Kashiwagi, Takayuki Asahina, Yasushi Tanaka, Yoshihumi Takagi, Yoshihiko Nishio, Hideki Hidaka, Ryuichi Kikkawa, Yukio Shigeta
Journal: Metabolism (1993)
Fixed Defect on Stress Myocardial Imaging Resulting From Previous Trauma Masquerading as Coronary Artery Disease
Authors: Jason T. Bradley, Piraon Sutthiwan, Leigh Ann Jenkins, Gary E. Meyerrose
Journal: Clinical Nuclear Medicine (2005)

Myocardial perfusion imaging is a useful adjunct to exercise or pharmacologic stress testing in the detection of coronary artery disease. However, this modality is prone to false-positive results mostly related to patient body habitus. A 63-year-old woman was admitted with anginal chest pain. Cardiac enzymes were negative, and the patient underwent adenosine Tc-99m tetrofosmin stress testing. Perfusion imaging revealed a predominantly fixed defect involving the anterior and anterolateral walls of the left ventricle and an ejection fraction of 31%. Subsequently, the patient had a cardiac catheterization that showed normal coronary arteries and a focal aneurysm in the anterior wall.
The ageing population of the United Kingdom and cardiovascular disease
Authors: Azeem Majeed, Paul Aylin
Journal: BMJ (2005)

The ageing population of the United Kingdom and cardiovascular disease Diseases of the cardiovascular system are the commonest cause of death in the United Kingdom and are responsible for a significant proportion of NHS spending. 1 We examined the possible impact of the ageing population on the expected number of people with coronary heart disease, heart failure, and atrial fibrillation.The data for the estimates of prevalence came from 211 general practices (total list size 1.4 million) contributing data to the general practice research database (GPRD). 2 The data for hospital admissions came from English hospital episode statistics. 3 The total number of cases and inpatient admissions for coronary heart disease, heart failure, and atrial fibrillation in the United Kingdom in 2001 and 2031 were estimated by applying age-sex specific rates to the number of people in each age-sex group in the relevant year.The numbers for each age-sex group were then summed to give the overall total number of cases.This method assumes that the age-sex specific prevalence and admission rates of these diseases will not change in the future.The estimated numbers of cases of coronary heart disease, heart failure, and atrial fibrillation in the United Kingdom in 2001 and 2031 are contained in the figure.The estimated numbers of inpatient admissions for coronary heart disease, heart failure, and atrial fibrillation in the United Kingdom in 2001 and 2031 are in the figure on bmj.com.This month's Dr Foster's case notes were compiled by Azeem Majeed and Paul Aylin.Dr Foster is an independent research and publishing organisation created to examine measures of clinical performance.