BACTERIAL RESISTANCE TO ANTIBIOTICS
Authors: C P MILLER
Journal: Annals of Internal Medicine (1948)

Article1 November 1948BACTERIAL RESISTANCE TO ANTIBIOTICSC. PHILLIP MILLER, M.D., F.A.C.P.C. PHILLIP MILLER, M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-29-5-765 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe development of resistance to the antibiotic drugs is a problem of theoretical interest to the bacteriologist and of practical importance to the clinician.I should like to describe briefly some experimental studies on the development of bacterial resistance to penicillin and streptomycin and then discuss the clinical implications suggested by these laboratory observations.DEVELOPMENT OF PENICILLIN RESISTANCEResistance to penicillin can develop in some bacteria, but it usually develops slowly. Meningococcus, for example, has been found to acquire resistance to penicillin if it is repeatedly subcultured onto media containing increasing concentrations of the drug. The graph in figure 1...Bibliography1. MILLERBOHNHOFF CPM: Studies on action of penicillin. V. Virulence of penicillin resistant strains of meningococcus, Proc. Soc. Exper. Biol. and Med., 1945, lx, 356-357. MILLER, C. P., and BOHNHOFF, M.: Studies on the action of penicillin. VI. Further observations on the development of penicillin resistance by meningococcus in vitro, Jr. Infect. Dis., 1947, lxxxi, 147-156. CrossrefGoogle Scholar2. DEMEREC M: Production of staphylococcus strains resistant to various concentrations of penicillin, Proc. Nat. Acad. Sci., 1945, xxxi, 16-24. CrossrefGoogle Scholar3. KLEIN M: A mechanism for the development of resistance to streptomycin and penicillin, Jr. Bact., 1947, liii, 463-467. CrossrefGoogle Scholar4. MILLERBOHNHOFF CPM: Studies on the action of penicillin. VII. 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RAKE G: Streptomycin as an essential nutrilite, Proc. Soc. Exper. Biol. and Med., 1948, lxvii, 249-253. CrossrefGoogle Scholar17. MILLERBOHNHOFF CPM: The effect of streptomycin therapy on the bacterial flora of the throat, Am. Jr. Med. (In press.) Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Chicago, Illinois*Presented at a General Session of the twenty-ninth annual meeting of the American College of Physicians, San Francisco, April 21, 1948.From the Department of Medicine, University of Chicago. Nextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byPharmaceuticals and the Environment (PiE): Evolution and impact of the published literature revealed by bibliometric analysisEmergence of Antibiotic-Resistant BacteriaStreptomycinresistente Varianten bei MeningokokkenAerosol therapy in the practice of allergyThe PhytoflagellatesThe Clinical Importance of Coagulase-Positive, Penicillin-Resistant Staphylococcus aureusStreptomycin–Dependent BacteriaStreptomycin as a Prophylactic AgentTreatment of Common Forms of Meningitis 1 November 1948Volume 29, Issue 5Page: 765-774KeywordsAntibiotic resistanceAntibioticsAttentionBacteriaDrugsNeisseria meningitidisPenicillinResearch laboratoriesStreptomycin ePublished: 1 December 2008 Issue Published: 1 November 1948 Copyright & PermissionsCopyright, 1948, by The American College of PhysiciansPDF downloadLoading ...