tbuckley/cabot-search huggingface dataset:
Abstract 13267: Circulating Anti-Intercalated-Disk Autoantibodies are Non-Invasive Markers of High Cellular Rejection Burden in Heart Transplantation
Authors: Alida L Caforio, Annalisa Angelini, Stefania Bottaro, Luca Brugnaro, Francesco Bagato, Ilaria Loddo, Francesco Tona, Giuseppe Feltrin, Vera Renier, Gaetano Thiene, Gino Gerosa, Sabino Iliceto
Journal: Circulation (2011)

Objective: Serum anti-heart (AHA) and anti-intercalated-disk (AIDA) autoantibodies are markers of autoimmune myocardial disease prior to heart transplantation (HTx). Autoimmune response may occur a...
Abstract 14034: Real-Time 3D Echocardiographic Quantification of Left Atrial Volume: Multicenter Study for Validation with Magnetic Resonance Imaging
Authors: Victor Mor-Avi, Chattanong Yodwut, Carly Jenkins, Harald Kuhl, Hans-Joachim Nesser, Thomas H Marwick, Andreas Franke, Johannes Niel, Regina Steringer-Mascherbauer, Lissa Sugeng, Roberto M Lang
Journal: Circulation (2011)

Background: Left atrial volume (LAV) is an important predictor of adverse cardiovascular events. LAV measurements are routinely performed using two-dimensional echocardiography (2DE). This methodol...
Mortality among outpatients with anxiety disorders
Authors: Coryell W, Noyes R, House Jd
Journal: American Journal of Psychiatry (1986)

An earlier follow-up of inpatients with panic disorder attributed excess mortality among men to death from unnatural causes and from cardiovascular disease. The present study sought to determine the stability of this finding with a 12-year follow-up of 155 outpatients with anxiety neurosis. As in the first study, men were twice as likely to die as expected, and this excess in deaths was attributable to cardiovascular disease and suicide. Given the small numbers in both studies, however, the link between panic disorder and excess cardiovascular mortality remains tentative.
Abstract 14981: Deletion of Fatty Acid Binding Protein-4 and -5 Exacerbate Cardiac Dysfunction Because of Insufficient Adenosine Triphosphate Production during Pressure Overload in Mice
Authors: Mas R Syamsunarno, Tatsuya Iso, Norimichi Koitabashi, Masahiko Kurabayashi
Journal: Circulation (2014)

Introduction: The heart requires a high level of energy supply to generate a large amount of adenosine triphosphate (ATP) for maintenance of its mechanical function. Fatty acid (FA) is central energy substrate for the ATP production while glucose utilization is dynamically regulated in response to cardiac stress such as pressure-overload. We recently reported that capillary endothelial FA binding protein-4 and -5 (FABP4/5) play a critical role in FA uptake in the heart. FA uptake was reduced by 30-40% in the heart in FABP4/5 DKO (double knockout) as compared with WT (wild-type) mice while glucose uptake was 20-fold higher in DKO mice. Metabolome analysis further revealed that PCr (creatine phosphate, reserve energy) was reduced by 30% in DKO hearts while ATP content was kept at a normal level. These findings imply that ATP production is diminished and replenished by PCr in DKO mice despite remarkable and compensatory glucose utilization.

Hypothesis: The remarkable change of cardiac energy substrates (shift from FA to glucose) in DKO mice influences cardiac function under pressure overload by transverse aortic constriction (TAC).

Results: Three weeks after TAC, 20% of DKO died while all of WT mice survived. Consistent with this, echocardiography revealed that fractional shortening of left ventricle was significantly reduced in DKO mice that showed more cardiac hypertrophy. We further assessed cardiac uptake of FA and glucose by using 125I-BMIPP and 18F-FDG, respectively. In the presence of TAC, FA uptake declined by 30% in WT mice and by 50% in DKO compared with WT at baseline. Glucose uptake was 10-fold higher in WT mice and 40-fold higher in DKO compared with WT at baseline. Metabolome profiling further showed that after a week of TAC, PCr was reduced by 40% in WT mice and by 80% in DKO compared with WT at baseline, indicating that pressure overload resulted in a depletion of energy substrates in DKO heart despite the robust increase in glucose uptake.

Conclusions: FABP4/5 are indispensable to maintain the continuous mechanical function of the heart during high-workload condition, implying the importance of FA uptake at basal condition because compensatory massive increase in glucose utilization is not sufficient to meet the heightened demand for ATP synthesis.
Splenic Puncture as a Diagnostic Procedure in Infancy and Childhood
Authors: Julius H. Hess
Journal: Annals of Internal Medicine (1930)

Article1 November 1930Splenic Puncture as a Diagnostic Procedure in Infancy and ChildhoodJULIUS H. HESS, M.D.JULIUS H. HESS, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-4-5-467 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptAt no period during life is an enlarged spleen so common a finding as in infancy and childhood. However, emphasis should be placed on the fact that an enlarged spleen frequently does not have the same significance in early life that it does in adults. This applies more especially to the acute splenomegaly of moderate degree as seen during acute infections and the chronic splenomegaly associated with nutritional disturbances.In a review of the literature numerous classifications of splenomegaly are found, some of them quite complete but none entirely satisfactory from either an etiological, pathological or clinical standpoint. Our limited... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: JULIUS H. HESS, M.D.Affiliations: Chicago, Ill.*Read at the meeting of the American College of Physicians, Minneapolis, Minn., February 12, 1930. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 November 1930Volume 4, Issue 5 Page: 467-483 Keywords Nutrition Splenomegaly ePublished: 1 December 2008 Issue Published: 1 November 1930 PDF downloadLoading ...
44. THE PROGNOSIS WITH THE INSULIN SHOCK THERAPY AND THE INTERPRETATION OF THE PROCESS OF RECOVERY
Authors: V. Nicolajev, R. Werner
Journal: American Journal of Psychiatry (1938)

The shock treatment affects non-specifically the brain and inactivates the morbid process there. Whether it also acts on the somatic causa morbi is not known. Certainly the inherited schizophrenic constitution remains unaffected. At any rate it is of great value to possess a tool with which we can remove an important link in the pathogenetic chain, the reactive process in the brain.
Abstract 16930: Inhibition of Glutamine Synthase Causes Glucose Intolerance in Mice
Authors: Andre Dejam, Marcos Alborghetti, John O’Sullivan, Robert E Gerszten
Journal: Circulation (2014)

Background: We recently performed metabolite profiling in 2,346 non-diabetic participants in the Framingham Offspring cohort. The glutamine/glutamate ratio was among the strongest predictors of the development of type II diabetes mellitus (DMII) during a 12-year follow-up period. Glutamate and glutamine are in a precursor-product relationship via the enzyme glutamine synthase (GS). Hypothesis: We hypothesized that inhibition of systemic GS activity would decrease the circulating glutamine/glutamate ratio and worsen glucose homeostasis in vivo. Methods: We administered 20 mg/kg of methionine sulfoximine (MSO), an irreversible inhibitor of GS, to 12 - 16 week old C57Bl6 mice intraperitoneally (i.p.) over 14 days (every other day for 7 injections). We then performed an intraperitoneal glucose tolerance test (IPGTT) with glucose measurements at 0, 30, 60, 90, 120 min from the tail vein. In a separate cohort of mice, we administered a single dose of 300 mg/kg of glutamine to both MSO-treated and control mice to assess reversibility of MSO effects. Results: Administration of MSO decreased circulating glutamine levels (n = 18, -64 ± 19% from baseline, p &lt; 0.01), whereas glutamate levels increased significantly (n = 18, +25 ± 8, p = 0.03). The glutamine/glutamate ratio decreased from 2.16 ± 0.16 to 0.44 ± 0.03 (n = 12, p &lt; 0.001). In the MSO-treated mice, the area under the curve of glucose excursion during the IPGTT increased markedly (n = 24, 12,098 ± 452 vs. 8,158 ± 368 AU, p &lt; 0.001). In livers isolated from MSO-treated animals, we documented reduced liver GS activity by 94 ± 3% (n = 24, p &lt; 0.001). Further, glutamine treatment of the MSO-treated animals at a dose of 300 mg/kg i.p. reversed the diabetogenic effects of MSO treatment (n = 12, 12,687 ± 568 vs 9,235 ± 399 AU, p &lt; 0.01). Conclusion: Inhibition of systemic GS causes a reversal of the plasma glutamine/glutamate ratio and worsening of glucose tolerance. Glutamine administration rescues MSO-induced glucose intolerance. These studies implicate glutamine/glutamate metabolism in the control of glucose homeostasis. Further studies will focus on the mechanism of MSO-induced glucose intolerance and relate the murine findings to human pathology.
Abstract 4038: Prediction of Outcome After Cardiac Arrest and Induced Hypothermia
Authors: Hans Friberg, Malin Rundgren
Journal: Circulation (2008)

Prediction of outcome in comatose survivors after cardiac arrest is difficult and is further complicated with the introduction of hypothermia as a treatment option, since sedation and intermittent use of paralyzers are mandated. Other means of prognostication, unaffected by pharmaceuticals, are warranted. We present data from a coma project, where the aim was to evaluate prognostic means by themselves or in combination. All patients included to hypothermia treatment after cardiac arrest, independent of the initial rhythm or the location of arrest, were included. A standardised protocol for monitoring and evaluation of neurological function and outcome was used (Fig 1 ). Patients were assessed at 72 h after normothermia, at which time a decision on level of care was taken. During a four-year period, 106 consecutive patients were included; 19 were excluded because of death prior to evaluation (15), protocol violation (3) and intracerebral bleeding (1). Of the remaining 87 patients, 50 patients regained consciousness within 72 h after normothermia and 37 patients were still in coma (GCS≤7). Among these 37 patients, 8 patients eventually regained consciousness, whereas 29 did not. Our 8 patients with a late recovery had a positive profile regarding aEEG (continuous pattern), NSE (&lt;27 ug/L at 48 h) and SSEP (cortical response), whereas 27 of 29 patients with persisting coma had at least one other strong marker for a bad outcome. A decision on level of care after cardiac arrest should be based on a neurological examination (GCS≤7) and at least one other prognostic tool. This should be performed no earlier than 72 h after normothermia. Fig 1:
Confirm diagnosis before giving thrombolytic treatment
Authors: N Milliet, C Diem, K Hayoz, F Sadry, E Herrera, V Phillips
Journal: BMJ (1994)

Early management of myocardial infarctionThe challenge for GPs is to change EDITOR,-At the same time as Hazel Wyllie and Francis Dunn were doing their study on use of aspirin in cases of chest pain in the north sector of Glasgow,' the first part of an audit was carried out among general practitioners in all of Glasgow over a period of a year.Half of those involved in 156 incidents of chest pain carried aspirin routinely, a fifth gave aspirin to patients with chest pain suspected of being myocardial infarction.The preliminary results were shown at the Scottish National GP Audit Symposium.Since then (and since Wyllie and Dunn's study) the results have been presented at meetings attended by Glasgow general practitioners and the need for aspirin discussed and emphasised.More meetings are planned.Chest pain at home can be difficult to diagnose and manage.Most chest pain is not cardiac in origin, and the presentation of myocardial infarction may not be classical.General practitioners tend to be concerned with assessing the patient, relieving symptoms, handling anxious relatives, and arranging for patients to be trans- ferred to hospital and given thrombolysis as soon as possible.Doubts over diagnosis may have inhibited use of aspirin in the past, and it is not long since aspirin was being pilloried for its side effects.Intravenous analgesia in the patient's home is not always without hazard.In a city like Glasgow with "immediate" ambulances patient transfer is quick.Wyllie and Dunn's study depended on the recollections of patients who were unwell.Our
Abstract 15284: Characteristics and Determinants of Cerebral Circulation in Patients after Surgery for Congenital Heart Disease
Authors: Hirofumi Saiki, Seiko Kuwata, Clara Kurishima, Yoichi Iwamoto, Hirotaka Ishido, Satoshi Masutani, Hideaki Senzaki
Journal: Circulation (2014)

Background: Neurodevelopmental delay and cerebral atrophy coupled with reduced blood flow are reportedly closely linked in patients with congenital heart diseases (CHD). However, the mechanisms to regulate cerebral flow in the same are unclear. Cardiac output and underlying cerebral arterial resistance that is constructed during infancy may affect blood perfusion. We tested our hypothesis that cerebral blood flow in patients with repaired CHD is affected by the original features of CHD. Method: Ninety children including 50 patients with biventricular repaired CHD (ToF 27, TGA 15, CoA+VSD 8), 15 with a single ventricle (SV: Glenn7/Fontan8) and 25 with negligible shunts and otherwise normal stracture heart were enrolled. During cardiac catheterization, cardiac index (CI), blood pressure, central venous pressure were measured before and after inferior vena cava occlusion. Assuming that cerebral resistance (Rc) and lower body resistance (Ri) are constant during IVC occlusion, the resistance and blood distribution to the brain and lower body were calculated as a parallel resistance circuit. The impacts of hemodynamics on the cerebral circulation were analyzed. Result: The cerebral portion of cardiac index (CIc) was negatively correlated with age (CIc=1.88-0.06*Age, p&lt;.05) and positively correlated with the CI (CIc=0.26+0.35*CI, p&lt;.0001). As expected, the cerebral resistance (Rc) increased significantly with age (p&lt;.05), whereas the resistance ratio defined as the Rc/Ri was independent of age, body size, disease, and surgical history. Multivariate analysis revealed that the CI was the independent determinant of CIc, regardless of the underlying diseases (p&lt;.01, β=0.27). Interestingly, after adjusting for age and CI, repaired CoA exhibited significantly higher Rs/Ri ratio (p&lt;.01) and lower CIc (p&lt;.05) than other groups, whereas SV patients showed significantly increased CIc, CIc/CI ratio and lower Rc compared to other groups (p&lt;.05). Conclusion: Apart from the strong governance of cerebral blood flow by cardiac output, cardiovascular property before anatomical repair and cavo-pulmonary connections have a significant impact on the cerebral circulation. Long-term effects of abnormal cerebral circulation warrants further studies.
Genetic variants in uracil processing enzymes are associated with abnormal DNA uracil content
Authors: Aurelie Chanson, Laurence Parnell, Jimmy Crott, Sang Choi, Haewook Han, Joel Mason
Journal: Cancer Research (2008)

AACR Annual Meeting-- Apr 12-16, 2008; San Diego, CA

1891 

Introduction. Maintenance of DNA integrity through DNA repair is critical in cancer prevention. Among the enzymes involved in DNA repair are those that prevent or correct uracil misincorporation in DNA. Repair of misincorporated uracil is important since it can cause double-stranded DNA breaks and other mutagenic events that can initiate or promote carcinogenesis. Also relevant is the B-vitamin folate as it is a co-factor in the enzymatic conversion of uracil to thymidine, and its deficiency promotes uracil misincorporation in DNA. Moreover, folate and other B vitamins are implicated as factors modulating cancer risk. Five genes encode the enzymes involved in uracil-repair in humans, for which many single nucleotide polymorphisms (SNPs) have been identified. However, their phenotypes have not yet been explored. Our goal is to identify SNPs in uracil processing genes that are determinants of DNA uracil levels, and to study how B vitamin status affects these relationships. Methods. Twenty-two SNPs were selected with a bioinformatics approach that identified variants with probable functional consequences and from distinct linkage groups. Association between SNP genotypes and uracil levels in blood DNA was tested in a cohort of 91 unrelated South Koreans. Results. Multiple linear regression analyses showed that five SNPs in two of the uracil-repair genes were significantly associated with uracil levels. Four of them were associated with an increase in uracil in the homozygous variant individuals compared to the homozygous wild-type subjects, and one was associated with a decrease (see table). Four SNPs were located in non-coding regions whereas one was a non-synonymous SNP within an exon that is predicted to change the protein sequence. No interactions between B vitamin levels, SNP genotypes and uracil levels were found in this study. Conclusion. We identified 5 SNPs with a biochemical phenotype that may impact on cancer risk. We are presently confirming our observations in a larger study.

View this table:
Aberrant Expression of Human Achaete-Scute Homologue Gene 1 in the Gastrointestinal Neuroendocrine Carcinomas
Authors: Takashi Shida, Mitsuko Furuya, Takashi Nikaido, Takashi Kishimoto, Keiji Koda, Kenji Oda, Yukio Nakatani, Masaru Miyazaki, Hiroshi Ishikura
Journal: Clinical Cancer Research (2005)

Abstract Purpose: Gastrointestinal neuroendocrine carcinoma (NEC) is extremely aggressive, but its pathophysiologic features remain poorly understood. There have been no biologically specific markers for this disease. In this study, distinctive up-regulation of human achaete-scute homologue 1 (hASH1) in gastrointestinal NECs was clarified. Experimental Design: Expression of hASH1 in NECs (n=10), carcinoid tumors (n = 10), other tumors (10adenocarcinomas, 2 squamous cell carcinomas and 1 malignant lymphoma), and the corresponding normal mucosa were investigated by in situ hybridization, reverse transcription-PCR (RT-PCR), real-time RT-PCR, and immunohistochemistry. Results: By in situ hybridization, mild to intense signals of hASH1 mRNA were detected in 9 of 10 NECs, but not in other tumors or normal mucosa, except for focally weak signals in one carcinoid tumor. RT-PCR showed strong expression of hASH1 in a small cell NEC, followed by a moderately differentiated NEC, and a carcinoid tumor, whereas it is undetectable in adenocarcinomas or normal mucosa. By real-time RT-PCR, the amounts of hASH1 mRNA in a small cell NEC were 16,600 times higher than those in adenocarcinomas and 110 times higher than those in a carcinoid tumor. Immunohistochemically, mammalian homologue of hASH1 was positive in 7 of 10 NECs but was negative in the other tumors. Pan-endocrine markers chromogranin A and synaptophysin were positive in almost all carcinoid tumors, in 4 and 7 of the 10 NECs, respectively. Conclusions: These findings revealed that hASH1 is distinctly up-regulated in gastrointestinal NECs. hASH1 may be used as a more sensitive and specific marker than conventional pan-endocrine markers for clinical diagnosis of gastrointestinal NECs.
Abstract P4-15-22: The ASCO/CAP guideline update for HER2 testing increases the number of breast cancer patients eligible for HER2-targeted therapy
Authors: Juliana Giacomazzi, Carolina R Hartmann, Diego D Paskulin, Luis Fernando Rivero, Maira Caleffi, Alessandro C Pasqualotto, Marcia S Graudenz, Daniela D Rosa
Journal: Cancer Research (2015)

Abstract Background: The American Society of Clinical Oncology/College of American Pathologists (ASCO/CAP) published, in Nov/2013, the interpretive guidelines for HER2 testing of breast cancer patients. This aimed to improve the accuracy of HER2 testing and its utility as a predictive marker in invasive breast cancer. The former version of these criteria was written in 2007. Objectives: to compare the HER2 immunohistochemical (IHC) analysis using the 2007 versus 2013 algorithms in a cohort of breast cancer cases diagnosed in a single institution in Southern Brazil. The cases were previously classified as HER2 1+ or 2+, using the 2007 criteria. Methods: the sample included 100 invasive breast cancer cases. The HercepTest (Dako, Denmark) was used for determination of HER2 expression. The HER2 testing was analyzed independently by two pathologists. The FISH analysis was done using a HER2/D17Z1 probe set. Preliminary Results: The HER2 IHC interpretation changed in 11/69 (15.9%) cases: 8.7% negative or equivocal cases by the 2007 guidelines were positive by the 2013 classification and 7.2% of HER2 1+ cases became equivocal (p&amp;lt;0.001; x2 test). The FISH analyses are ongoing. Conclusion: The 2013 ASCO/CAP guidelines resulted in less negative cases and in more equivocal (requiring reflex testing) and positive tests. Applying the ASCO/CAP 2013 guidelines resulted in a significantly increase of breast cancer patients eligible for HER2-targeted therapies. Citation Format: Juliana Giacomazzi, Carolina R Hartmann, Diego D Paskulin, Luis Fernando Rivero, Maira Caleffi, Alessandro C Pasqualotto, Marcia S Graudenz, Daniela D Rosa. The ASCO/CAP guideline update for HER2 testing increases the number of breast cancer patients eligible for HER2-targeted therapy [abstract]. In: Proceedings of the Thirty-Seventh Annual CTRC-AACR San Antonio Breast Cancer Symposium: 2014 Dec 9-13; San Antonio, TX. Philadelphia (PA): AACR; Cancer Res 2015;75(9 Suppl):Abstract nr P4-15-22.
Cpipe: a shared variant detection pipeline designed for diagnostic settings
Authors: Simon P. Sadedin, Harriet Dashnow, Paul A. James, Melanie Bahlo, Denis C. Bauer, Andrew Lonie, Sebastian Lunke, Ivan Macciocca, Jason P. Ross, Kirby R. Siemering, Zornitza Stark, Susan M. White, Graham Taylor, Clara Gaff, Alicia Oshlack, Natalie P. Thorne
Journal: Genome Medicine (2015)
Abstract 16598: Regular Exercise Training Reduce Coronary Restenosis after Percutaneous Coronary Intervention in Patients With Acute Myocardial Infarction
Authors: Jeong Hoon Kim, Byung Ok Kim, Young-Sup Byun, Sungwoo Cho, Choong Won Goh, Hyo Seung Ahn, Kun Joo Rhee, Hye Young Lee, Ji Min Chang, Chul Kim
Journal: Circulation (2011)

Hye Young Lee, 2011 Finalist and Presenting Author