The Granularity of the Juxtaglomerular Cells in Human Hypertension
Authors: H. D. ITSKOVITZ
Journal: Annals of Internal Medicine (1963)

Article1 July 1963The Granularity of the Juxtaglomerular Cells in Human HypertensionHistologic and Clinical CorrelationsH. D. ITSKOVITZ, M.D., E. A. HILDRETH, M.D., F.A.C.P., A. M. SELLERS, M.D., F.A.C.P., W. S. BLAKEMORE, M.D., F.A.C.S.H. D. ITSKOVITZ, M.D.Search for more papers by this author, E. A. HILDRETH, M.D., F.A.C.P.Search for more papers by this author, A. M. SELLERS, M.D., F.A.C.P.Search for more papers by this author, W. S. BLAKEMORE, M.D., F.A.C.S.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-59-1-8 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptRecent studies relating renin and angiotensin to the regulation of aldosterone secretion have stimulated renewed interest in the juxtaglomerular cells of the kidney and in their role in normal body physiology and in human hypertension (1-5). The juxtaglomerular cells are located in the terminal portion of the renal afferent arteriole (6). They contain cytoplasmic granules which are believed to be renin or a precursor of renin (5, 7-9). Under normal circumstances, the human kidney has few juxtaglomerular granules and little renin activity (10). When the arterial blood flow to the kidney is sufficiently compromised, as demonstrated by Goldblatt (11), the...References1. DAVISHARTROFTTITUSCARPENTERAYERSSPIEGEL JOPMEOCCCRHE: The role of the renin-angiotensin system in the control of aldosterone secretion. J. Clin. Invest. 41: 378, 1962. CrossrefMedlineGoogle Scholar2. DAVISCARPENTERAYERSHOLMANBAHNCASPARCAVANAUGH JOCCCRJERCAE: Evidence for secretion of an aldosterone stimulating hormone by the kidney. J. Clin. Invest. 40: 684, 1961. CrossrefMedlineGoogle Scholar3. DAVISAYERSCARPENTER JOCRCC: Renal origin of an aldosterone stimulating hormone in dogs with thoracic caval constriction and in sodium depleted dogs. Ibid., 1466. 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Author, Article, and Disclosure InformationAffiliations: Philadelphia, PennsylvaniaFrom the Hypertension Section, Edward B. Robinette Foundation, Department of Medicine and Department of Surgery, Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania.This investigation has been supported in part by the Heart Association of Southeastern Pennsylvania, by grant OG-16, Division of General Medical Sciences, National Institutes of Health, and by grant H 5139 of the United States Public Health Service.Dr. Hildreth is a John and Mary R. Markle Scholar in Medicine, 1958-1963.Requests for reprints should be addressed to Harold D. Itskovitz, M.D., Hypertension Section, Edward B. Robinette Foundation, University of Pennsylvania Hospital, Philadelphia 4, Pennsylvania. 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