tbuckley/cabot-search huggingface dataset:
Anti periplakin antibodies in connective tissue-associated lung fibrosis
Authors: Camille Taillé, Mathilde Neuville, Sabine Grootenboer-Mignot, Philippe Dieudé, Yannick Allanore, Sylvie Chollet-Martin, Bruno Crestani
Journal: European Respiratory Journal (2013)

Introduction: Auto antibodies directed against periplakin (PPL), a desmosomal component, have been detected in 40 % of patients with idiopathic pulmonary fibrosis, and are associated with a more pronounced impairment of pulmonary function tests. We assessed whether anti PPL Abs could be detected in lung fibrosis associated with connective tissue diseases and whether their detection is associated with severity of the respiratory disease.  Material and methods: Anti PPL Abs were detected by immunoblot in the serum from 101 patients with rheumatoid arthritis (RA) and in 45 patients with systemic sclerosis (SSc).  Results: Anti PPL Abs were detected in 17/101 RA patients (16.8%) and in 13/45 SSc patients (28.9%) (P=0.07). ILD was detected in 25 RA (24%) and 19 SSc patients (45%). In RA patients, anti PPL Abs rate was similar in patients with (20%) and without ILD (15%, p=0.5). In SSc patients, detection of anti PPL Abs tends to be more frequent in patients with ILD (42% versus 19%, p=0.11). RA patients with anti PPL Abs did not differ from those without Abs for age, sex, smoking habits, age at onset, anti CCP status, bone erosions. Anti PPL Abs were more frequent in non Caucasian patients (33% versus 60%, p=0.006). SSc patients with anti PPL Abs were not different for age, sex, smoking, anti SCL70, anti RNP or anti centromere antibodies, pulmonary hypertension or other visceral manifestations. Among patients with ILD, with RA or SSc, lung function tests results were similar in anti PPL (+) and PPL (-) patients,.  Conclusion: Anti PPL Abs are frequently detected in patients with RA or SSc. Anti PPL Abs are not associated with the presence of ILD.
Characterization of Anti-Inflammatory Factors Produced by Murine Tumor Cells in Culture&lt;xref ref-type="fn" rid="FN2"&gt;2&lt;/xref&gt;&lt;xref ref-type="fn" rid="FN3"&gt;3&lt;/xref&gt;
Authors: S J Normann, J Cornelius
Journal: JNCI Journal of the National Cancer Institute (1982)

P-815 mastocytoma cells from DBA/2 mice and a 3-methylcholanthrene-induced fibrosarcoma from C57BL/6 mice produced in culture at least two soluble anti-inflammatory factors that inhibited macrophage accumulation in vivo when the factors were injected sc into syngeneic recipients. One factor was a low-molecularweight peptide <1,000), as judged by ultrafiltration, failure of extraction by lipid solvents, nonsusceptibility to DNase or RNase, partial inactivation by trypsin, and complete inactivation by carboxypeptidase B. The second anti-inflammatory factor had a molecular weight between 30,000 and 100,000 and was also not extractable with lipid solvents. Production of anti-inflammatory factors by P-815 mastocytoma cells was inhibited by cycloheximide and cell irradiation but not by colchicine pretreatment of the cells, suggesting a relationship to protein synthesis rather than cell growth. Soluble anti-inflammatory factors depressed granulocyte as well as macrophage responses. Anti-inflammatory factors were not found in supernatants from cultures of splenocytes, peritoneal exudate cells, or murine lung fibroblasts.
Studies of the Mechanisms for the Induction of In Vivo Tumor Immunity. II. Distribution and Homing of Cytotoxic Effector and Precursor Cells
Authors: Chou-Chik Ting
Journal: JNCI Journal of the National Cancer Institute (1978)

Journal Article Studies of the Mechanisms for the Induction of In Vivo Tumor Immunity. II. Distribution and Homing of Cytotoxic Effector and Precursor Cells Get access Chou-Chik Ting Chou-Chik Ting Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 60, Issue 2, February 1978, Pages 437–444, https://doi.org/10.1093/jnci/60.2.437 Published: 01 February 1978 Article history Received: 08 July 1977 Accepted: 08 September 1977 Published: 01 February 1978
VO2 kinetics in asthmatic adolescents: A pilot study
Authors: Mario Canciano Canciani, Andrea Bon, Ilaria Cadel, Raffaella Moretti, Margherita Robazza, Stefano Poser
Journal: European Respiratory Journal (2011)

In normal subjects, ventilatory rate and oxygen ventilation (VO2) increases during exercise from a resting state until maximal levels are attained, whereas it seems that in asthmatic patients this increase is higher. The aim of the study was to evaluate the kinetics of VO2 during a constant-load exercise in a group of 11-16 y.o. asthmatic patients. 17 adolescents with mild stable asthma were studied. On the first day a progressive workload was applied to calculate the presumable aerobic threshold, which was assumed to be 80% of the maximum load tolerated. On the next day the subjects were asked to pedal at this constant load and the VO2 kinetics were studied with a K4B2 and a Cosmed® cycloergometer. In 9 patients (53%) there was an increasing trend of VO2 consumption, whereas in 5 (29%) this trend was not highlighted. In 3 patients (18%) data was unobtainable because of incompletion of test or non-cooperation. In conclusion, it was not possible to outline a common pattern of VO2 consumption, but in more than a half of our patients the behaviour of VO2 consumption during constant load was similar to that of the normal population.
Fungus ball diagnosed on computed tomography (CT) guided needle biopsy of thoracic lesions
Authors: Mehrdad Bakhshayesh, Pooyeh Graili, Soheyla Zahirifard
Journal: European Respiratory Journal (2011)

Background:  CT-guided biopsy provides results in a short period and can be applied on outpatient and even high risk patients however; some studies do not recommend it in lesions with benign histology probability   Objectives:  To report our experience regarding fungus ball diagnosis on CT-guided biopsy and to identify the complication rate of procedure.   Materials and methods:  We evaluated 99 CT-guided biopsies of infected thoracic lesions performed from March 2004 to December 2008, retrospectively. All biopsies were performed by one radiologist by westcott needle number 20 and 18. The CTs were assessed by a trained general practitioner for the size and location of lesions and pneumothorax or pneumomediastinum diagnosis and then all CTs were double checked by the same radiologist. Lesions considered fungus and their differentiations based on pathology reports.   Results:  During four year study 20 fungus lesions (15 male and 5 female) were found with the mean age 54.75 years (ranging: 19-77). In these series there were 16 (80%) Aspergillosis, 2 (10%) Mucor mycosis and 2 undifferentiated fungus bal. The mean diameter of lesions and lesion distance to chest wall were 5.650 cm (range: 1 to 11.5) and 0.75 cm (range: 0 to 3), respectively. Nine (45%) fungus lesions were located in left upper, 4 (20%) in right lower, 4 (20%) in right upper and the rest (15%) in left lower and right middle lobes. Pneumothorax occurred in 2 cases (1 Aspergillosis and 1 Mucor mycosis) while chest tube was placed only for patient with Mucor mycosis to manage the complication.   Conclusion:  CT-guided needle biopsy seems to be safe and feasible diagnostic modality with low risk probability of complications for fungus balls.
NIV for MND in the West of Scotland assisted ventilation service (WoSAVS)
Authors: Peter Kewin, Selina Tsim, Janice McGlone, Alison Clarke, Stephen Banham, Scott Davidson
Journal: European Respiratory Journal (2011)

Introduction:  Motor neuron disease (MND) results in respiratory muscle weakness and respiratory failure (RF), with reduced quality of life (QOL) and survival. Non-invasive ventilation (NIV) effectively palliates symptoms related to RF, improves QOL and survival (Bourke, Lancet Neurol 2006), and increasing use is reflected in recent guidelines (NICE CG105, 2010). We aimed to evaluate our current practice using NIV in MND.   Methods:  MND referrals (Sept 07 – Aug 10) to the WoSAVS were identified. Data on clinical status, RF (high PCO2 or HCO3 on CBG), and progression were collected.   Results:  Of 38 patients referred (12.7 per yr; 4 per yr 1999-2002), 21 were in RF at 1st AVS assessment. RF developed in 1/17 during followup (3 patients no data). Patients with RF were referred and assessed sooner after diagnosis, and died earlier. NIV was commenced within 2 weeks of assessment, although half were commenced within 48 hours (data not shown). Those accepting NIV had a similar degree of RF to those that did not, but lived longer (210 vs 33 days) with good NIV compliance (data not shown).   Conclusions:  MND referrals have tripled in a decade of NIV use, and will increase further with recent guideline publication, so services must develop to meet this need. Early referral and assessment avoids crisis driven decision making, but the majority of our patients were in RF requiring prompt intervention. Early specialist referral must be encouraged.
Effect of oral N-acetylcysteine (NAC) on volume and albumin content of respiratory tract fluid but not on epithelial secretory cell number in "smoking" rats
Authors: N Robinson, R Brattsand, M Dahlback
Journal: European Respiratory Journal (1990)

This study was designed to look at the effect of N-acetylcysteine (NAC) on epithelial secretory cells and the respiratory tract fluid volume and albumin content from the lower airways of "bronchitic" rats. Rats were exposed either to tobacco smoke (TS), TS and NAC, or NAC alone. TS caused a significant increase in epithelial secretory cell number which was not reduced by concomitant NAC administration; NAC alone had no effect on cell numbers. TS increased respiratory tract fluid volume and albumin content by a small but non-significant amount, whereas TS and NAC increased the volume and albumin content by a greater and significant amount; NAC alone was also shown to significantly increase both fluid volume and albumin content.
Clinical analysisof patients with pulmonary nontuberculous mycobacterial disease complicated with pneumothorax
Authors: Yoshihiro Kobashi, Keiji Mouri, Yasushi Obase, Shigeki Kato, Mikio Oka
Journal: European Respiratory Journal (2013)

Purpose: There are a few studies which analyzed many patients with pulmonary nontuberculous mycobacterial (NTM) disease complicated with pneumothorax. To clarify the clinical characteristics of patients with pulmonary NTM disease complicated with pneumothorax.  Materials and Methods: Two hundred twenty patients satisfied the diagnostic criteria of NTM disease proposed by ATS. Nine patients with pulmonary NTM disease were complicated with pneumothorax. We investigated the background, laboratory findings, radiological findings, treatment and prognosis.  Results: There were nine patients, 6 males and 3 females, with a mean age of 73.9 years old. Seven patients had underlying respiratory disease such as COPD. The causative microorganisms were Mycobacterium avium in 4 patients, M. intracellulare in 4, and M. kansasii in 1, respectively. Regarding the radioloical findings, pneumothorax was recognized in 5 patients in the right lung, 3 in the left, and 1 in both lungs heterogeneously. Although most patients showed multiple cavities and extensive lesion over unilateral lung fields, three patients were simultaneously diagnosed with pulmonary NTM disease at the onset of pneumothorax. As for treatment thoracic drainage was performed for seven patients, one was advised to rest only and one needed thoracic drainage and surgery. The responses to the treatment were poor and five patients died due to pneumonia or heart failure.  Conclusions: The rate of pneumothorax complications in patients with pulmonary NTM disease (4.1%) was higher compared to other reports. The response to treatment was poor, and the prognosis was also poor due to other complications.
Genomic alterations in paired pretreatment (pre) and progression (prog) tumor samples from ovarian cancer patients (pts) treated with pazopanib (pazo) or placebo (plb).
Authors: Florian Heitz, Robert C. Gagnon, Sang-Yoon Park, Jae Weon Kim, Ulrich Canzler, Gabriele Feisel, Rafael ÃƒÂlvarez Gallego, Andres Poveda, Alexander Burges, Kosei Hasegawa, Annette Jahn, Nuria Laínez, Mansoor Raza Mirza, Tjoung-Won Park-Simon, Sandrina Lambrechts, Yuan Liu, Anthony D'Amelio, Catherine Barrett, Ionel Mitrica, Philipp Harter
Journal: Journal of Clinical Oncology (2014)

5501 Background: BRCA mutational status, in combination with the accumulation of somatic mutations, has been associated with ovarian cancer prog and response to chemotherapy. AGO-OVAR16/VEG110655 is a randomized study to evaluate pazo vs plb in women with advanced ovarian cancer that have not progressed after first line chemotherapy. Paired pre and prog tumor samples were examined by next generation sequencing (NGS) to evaluate differences in tumor genomics, and to identify potential biomarkers for, and mechanisms of, resistance to pazo. Methods: Samples (n=22 pairs) were collected from consenting pts. DNA was isolated, followed by PCR. NGS was run on the Ion Torrent Proton Platform with 2 gene panels (409 comprehensive cancer gene panel [CCP] and BRCA1/2; AltheaDx). Data were aligned to hg19 and processed using ANNOVAR1, SIFT, PolyPhen programs, and COSMIC, 1000g and BIC databases. Mutation changes in paired samples were identified by allele frequency (AF) differences (prog minus pre) greater than 3xIQR (interquartile range) of differences from all markers determined to be damaging by both SIFT and PolyPhen. Results: CCP: after QC, N=15 pairs (8 pazo, 7 plb) were available for analysis. Synonymous (syn) alterations (67% of total) were removed; remaining alterations (n=11,587) were primarily non-syn (92%) and stopgain (4%). The AF cutoff was determined to be ±32. Changes in damaging mutations were observed in 47 markers across 40 genes. Pts in plb arm had greater number of changes compared to pazo arm (average 7/pt in plb arm vs 1.3/pt in pazo arm). Potential driver genes were FLT3 and ITGA9. BRCA1/2: N=20 pairs (10 pazo, 10 plb). After removing syn alterations (28% of total), remaining were primarily non-syn SNV (93%) and stopgain SNV (6%). The AF cutoff was ±17.5; 5 and 10 markers (BRCA1/2) had changes, of which 14/15 were in plb arm. Additional results will be presented. Conclusions: Changes in the genetic composition of tumors can be detected using NGS. In pre and prog matched tumor pairs, pts in plb arm had 6 fold higher number of genetic alterations per pt compared to pts in pazo arm. Potential driver genes have been identified.
Health, social and economic consequences of sleep disordered breathing: A controlled national study evaluating the societal effect on patients and their partners
Authors: Poul Jennum, Rikke Ibsen, Jakob Kjellberg
Journal: European Respiratory Journal (2012)

The objective direct and indirect costs of obstructive sleep apnea (OSA) and obesity hypoventilation syndrome (OHS) on patients and their partners are incompletely described.  Using data from the Danish National Patient Registry (1998-2010), 30278 OSA and 1562 OHS patients and their partners were identified. Four matched citizens based on age, gender and social status matched served as controls.  Direct costs were extracted from the Danish Ministry of Health, Danish Medicines Agency and National Health Security, and indirect costs from the Coherent Social Statistics.  66.2%/63.4% of all OSA/OHS patients was co-living versus 65.4%/65.6% of controls. OSA/OHS showed higher rates of health-related primary and secondary care, medication, unemployment, and other socioeconomic costs. The income level of OSA/OHS patients were lower. The annual mean excess total direct and indirect health-related cost for each patient was €2821 before and €5060 (p  Partner9s total health expenses and the public transfer income were higher, whereas the employment rate and income level were lower than controls. The annual mean excess total cost for each partner was €2639 before diagnosis and €3058 (p  These effects were present 11 years prior to an OSA/OHS diagnose in patients and partners, and increased with disease advancement.  OSA and especially OHS are associated with a major health and social effect affected employment and income level affecting the patients and partners.
Abstract 2997: Post-Operative Statin Use and Lower LDL Cholesterol Concentration Are Associated with Reduced Incidence of Stroke
Authors: Matthew C Becker, John M Galla, Ryan P Daly, Femi Philip, Peter Zimbwa, Stephen O Chen, Chen H Chow, Tingfei Hu, Richard A Krasuski, Arman T Askari
Journal: Circulation (2007)

Background : Post operative stroke remains a catastrophic and costly complication of coronary artery bypass grafting (CABG). Prior work has demonstrated a significant reduction in the rate of stroke associated with statin use in the non-operative setting. We evaluated the effect of post-operative statin use and LDL cholesterol concentration (LDL-C) on the incidence of stroke following CABG. Methods : The Cleveland Clinic Cardiothoracic Surgery Database was used to identify 5,205 consecutive patients who underwent first time, isolated CABG from 1/1993–12/2005. Patients with a prior history of atrial fibrillation, known clotting disorder, or requirement for anticoagulation were excluded from analysis. Discharge medications, including statins, were prospectively collected. Patients were divided into groups based upon serum LDL-C: &lt;70mg/dl, 70 –100, 101–130, or &gt;130. Results : The overall incidence of postoperative stroke at 1 year was 3.3% (181 events). Patients discharged on statin therapy were more likely to have a lower LDL-C and were significantly less likely to suffer a post operative stroke at 1 year (see table ). Multivariate logistic regression identified age (HR 1.05 [1.024, 1.075]; p&lt;0.001), peripheral vascular disease(1.89[1.233, 2.891]; p&lt;0.004), and renal disease (2.79 [1.654, 4.709]; p&lt;0.001) as independent predictors of the combination of stroke, MI, or death. Use of both statin (0.366 [0.177, 0.757]; p&lt;0.007) and ACE inhibitor (0.545 [0.36, 0.82]; p&lt;0.003) therapies significantly reduced this risk. Conclusions: In patients undergoing first time, isolated CABG, post-operative statin therapy was associated with lower LDL-C concentration which significantly reduced risk of stroke as well as the composite endpoint of death, MI, or stroke. These data suggest that a discharge regimen including statin therapy may reduce post-operative morbidity and warrants prospective validation.
Association between dynamic hyperinflation and emphysema distribution in COPD patients
Authors: Afroditi Boutou, Zaid Zoumot, Claire Davey, Arjun Nair, David Hansell, Michael Polkey, Nicholas Hopkinson
Journal: European Respiratory Journal (2014)

Introduction  Dynamic hyperinflation (DH) is a major contributor of both dyspnea and reduced exercise capacity among patients with Chronic Obstructive Pulmonary Disease (COPD). The relationship between the pattern of distribution of emphysema (homogeneous versus heterogeneous) and DH has not been previously studied.  Aim  To compare the impact of emphysema distribution on DH during a maximal cardiopulmonary exercise testing (CPET) in severe COPD.  Material-Methods  Data on COPD patients who underwent thorax high-resolution computed tomography, full lung function measurements and maximal CPET were retrospectively analysed. Resting inspiratory capacity (rIC) was calculated by averaging 4 resting IC manouvers. ΔIC was calculated by subtracting the peak IC (pIC), that is the IC measured during the last 30 seconds of maximum exercise, from rIC and was expressed as ratio of rIC (ΔICratio). Emphysema quantification was conducted at 3 predefined levels for each patient using the syngo PULMO-CT (Siemens AG); a difference >25% between best and worse slice defined heterogeneous emphysema. Student9s t-test was used for group comparison, after normality of distribution was assessed; level of p  Results  We identified 51 patients with heterogeneous emphysema (62.7% male; 60.9±7.5 years old; FEV 1 %=32.4±11.4; TLCO%=34.1±10) and 13 with homogeneous emphysema (61.5% male; 62.5±5.9 years old; FEV 1 %=28.1±10.3; TLCO%=33.3±11.5) who fulfilled the enrollment criteria. ΔICratio (0.40±0.1 vs 0.31±0.13, p=0.031) was higher in patients with homogeneous compared to those with heterogeneous emphysema.  Conclusion  Homogeneous emphysema is associated with more DH during maximum exercise in COPD patients.
Phase III Trial of Standard-Dose Intravenous Cisplatin Plus Paclitaxel Versus Moderately High-Dose Carboplatin Followed by Intravenous Paclitaxel and Intraperitoneal Cisplatin in Small-Volume Stage III Ovarian Carcinoma: An Intergroup Study of the Gynecologic Oncology Group, Southwestern Oncology Group, and Eastern Cooperative Oncology Group
Authors: Maurie Markman, Brian N. Bundy, David S. Alberts, Jeffrey M. Fowler, Daniel L. Clark-Pearson, Linda F. Carson, Scott Wadler, Joshua Sickel
Journal: Journal of Clinical Oncology (2001)

PURPOSE: To compare the progression-free and overall survival in small-volume residual ovarian cancer after treatment with intravenous (IV) cisplatin and paclitaxel or an experimental regimen of IV carboplatin followed by IV paclitaxel and intraperitoneal cisplatin. PATIENTS AND METHODS: Patients were randomized to receive either IV paclitaxel 135 mg/m 2 over 24 hours followed by IV cisplatin 75 mg/m 2 every 3 weeks for six courses or IV carboplatin (area under curve 9) every 28 days for two courses, then IV paclitaxel 135 mg/m 2 over 24 hours followed by intraperitoneal (IP) cisplatin 100 mg/m 2 every 3 weeks for six courses. RESULTS: Of the 523 patients who entered this trial, 462 were determined to be assessable, with prognostic factors well balanced between the treatments. Neutropenia, thrombocytopenia, and gastrointestinal and metabolic toxicities were greater in the experimental arm. As a result, 18% of the patients received ≤ two courses of IP therapy. Progression-free survival was superior for patients randomized to the experimental treatment arm (median, 28 v 22 months; relative risk, 0.78; log-rank P = .01, one-tail). There was a borderline improvement in overall survival associated with this regimen (median, 63 v 52 months; relative risk, 0.81; P = .05, one-tail). CONCLUSION: An experimental regimen including moderately high-dose IV carboplatin followed by IP paclitaxel and IV cisplatin yielded a significant improvement in progression-free survival when compared with a standard regimen of IV cisplatin and paclitaxel. Because the improvement in overall survival was of borderline statistical significance and toxicity was greater, the experimental arm is not recommended for routine use. However, the results provide direction for further clinical investigation in small-volume ovarian cancer.
Rebecca: a Large Cohort Study of Regorafenib (Reg) in the Real-Life Setting in Patients (Pts) Previously Treated for Metastatic Colorectal Cancer (Mcrc)
Authors: D. Tougeron, F. Desseigne, P.L. Etienne, L.M. Dourthe, L. Mineur, B. Paule, A. Hollebecque, E. Tresch, D. Spaeth, P. Michel, J. Dauba, P. Laplaige, C. Borg, D. Bechade, S. Clisant, J. Phelip, C.La De Fouchardiere, T. André, A. Adenis
Journal: Annals of Oncology (2014)