CHOLANGIOLITIC BILIARY CIRRHOSIS (PRIMARY BILIARY CIRRHOSIS)
Authors: W E RICKETTS, R W WISSLER
Journal: Annals of Internal Medicine (1952)

Article1 May 1952CHOLANGIOLITIC BILIARY CIRRHOSIS (PRIMARY BILIARY CIRRHOSIS)WILLIAM E. RICKETTS, M.D., Ph.D., ROBERT W. WISSLER, Ph.D., M.D.WILLIAM E. RICKETTS, M.D., Ph.D.Search for more papers by this author, ROBERT W. WISSLER, Ph.D., M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-36-5-1241 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptAmong the various forms of biliary cirrhosis a clinicopathologic entity can be segregated in which there is no obstruction or inflammation in the extrahepatic or larger intrahepatic biliary ducts or gall-bladder. Histologically, the main lesion consists of an inflammation in and around the smaller bile ducts (Hering's canals or junction ducts), or in the canaliculi between the lobules, or both. The term cholangioles has been broadly used1to include both the finer biliary radicles and the bile canaliculi, and the term cholangiolitic cirrhosis for the inflammation of these areas.1Rössle2has restricted the term cholangitic biliary cirrhosis to ascending cholangitis...Bibliography1. WatsonHoffbauer CJFW: The problem of prolonged hepatitis with particular reference to the cholangiolitic type and the development of cholangiolitic cirrhosis of the liver, Ann. Int. Med. 25: 195, 1946. LinkGoogle Scholar2. Rössle R: Entzündung der Leber, in: Henke, F., and Lubarsch, O.: Handbuch der speziellen pathologischen Anatomie und Histologie, 1930, Julius Springer, Berlin, Bd. V, Teil 1, 1938. Google Scholar3. MacMahon HE: Biliary xanthomatosis (xanthomatous biliary cirrhosis), Am. J. Path. 24: 527, 1948. MedlineGoogle Scholar4. Klemperer P: Chronic intrahepatic obliterating cholangitis, J. Mt. Sinai Hosp. 4: 527, 1948. Google Scholar5. Lichtman SS: Diseases of the liver, gallbladder and bile ducts, 1942, Lea and Febiger, Philadelphia. Google Scholar6. Karsner HT: Morphology and pathogenesis of hepatic cirrhosis, Am. J. Clin. Path. 13: 569, 1943. CrossrefGoogle Scholar7. LaManna S: Ueber die sogenannte Cholangitis lenta, Virchows Arch. f. path. Anat. 298: 515, 1936. CrossrefGoogle Scholar8. LaManna S: Zur Pathogenese der Cholangitiden, Virchows Arch. f. path. Anat. 298: 44, 1936. CrossrefGoogle Scholar9. RickettsKirsnerKippenPalmer WEJBDDWL: Tests of hepatic function in portal cirrhosis, Gastroenterology 15: 40, 1950. CrossrefMedlineGoogle Scholar10. RickettsSterlingKirsnerPalmer WEKJBWL: Electrophoretic studies of the serum proteins in portal cirrhosis, Gastroenterology 13: 205, 1949. MedlineGoogle Scholar11. Ahrens EH: Personal communication. Google Scholar12. Blakemore AH: Personal communication. Google Scholar13. AddisonGull TW: On a certain affection of the skin, vitiligoidea—a) plana; b) tuberosa, with remarks, Guy's Hosp. Rep. 7: 265, 1851. Google Scholar14. Weber FP: On biliary cirrhosis of the liver with and without cholelithiasis, Tr. Path. Soc. London 54: 103, 1902-03. Google Scholar15. Fagge CH: General xanthelasma or vitiligoidea, Tr. Path. Soc. London 24: 242, 1912-13. Google Scholar16. EustermanMontgomery GBH: Disorders of the liver and the extrahepatic bile ducts associated with xanthoma and hyperlipemia, Gastroenterology 3: 275, 1944. Google Scholar17. MacMahonThannhauser HESJ: Xanthomatous biliary cirrhosis (a clinical syndrome), Ann. Int. Med. 30: 121, 1949. LinkGoogle Scholar18. Moxon W: Jaundice and xanthelasma, Tr. Path. Soc. London 24: 129, 1873. Google Scholar19. Thannhauser SJ: Lipoidosis, 1940, Oxford University Press, New York. Google Scholar20. AhrensKunkel EHHG: The relationship between serum lipids and skin xanthomata in eighteen patients with primary biliary cirrhosis, J. Clin. Investigation 28: 1565, 1949. CrossrefMedlineGoogle Scholar21. Riisfeldt-Pederson O: Cirrhosis biliaris xanthomatosa, Nord. med. 47: 2000, 1943. Google Scholar22. Hayem G: Contribution à l'étude de l'hépatite interstitielle chronique avec hypertrophie (sclérose ou cirrhose hypertrophique du foie), Arch. de physiol. norm. et path. 6: 126, 1874. Google Scholar23. Olivier P: Memoir pour servire à l'histoire de la cirrhose hypertrophique, Union med. Paris 12: 361, 400, 449, 1871. Google Scholar24. Hanot V: Étude sur une forme de cirrhose hypertrophique du foie, Thesis, 1876, Libraire J. B. Bailliére et Fils, Paris. Google Scholar25. DauphineeSinclair JAJC: Primary biliary cirrhosis, Canad. M. A. J. 61: 1, 1949. MedlineGoogle Scholar26. GrayBarron SJES: The electrophoretic analysis of the serum proteins in diseases of the liver, J. Clin. Investigation 22: 191, 1943. CrossrefMedlineGoogle Scholar27. KunkelAhrens HGEH: The relationship between serum lipids and the electrophoretic pattern with particular reference to patients with primary biliary cirrhosis, J. Clin. Investigation 28: 1575, 1949. CrossrefMedlineGoogle Scholar28. SterlingRicketts KWE: Electrophoretic studies of the serum proteins in biliary cirrhosis, J. Clin. Investigation 28: 1469-1476, 1949. CrossrefMedlineGoogle Scholar29. CharcotGombault JMA: Contributions à l'étude anatomique des differentes formes de la cirrhose du foie, Arch. de physiol. norm. et path. 3: 453, 1876. Google Scholar30. CounsellerMclndoe VGAH: Dilatation of the bile ducts (hydrohepatosis), Surg., Gynec. and Obst. 43: 729, 1926. Google Scholar31. Unpublished data. Google Scholar32. ThannhauserMagendantz SJH: The different clinical groups of xanthomatous diseases; physiological study of 22 cases, Ann. Int. Med. 11: 1662, 1938. LinkGoogle Scholar33. RickettsKirsnerPalmer WEJBWL: Biliary cirrhosis—an evaluation of various liver tests, Gastroenterology 16: 404, 1950. CrossrefMedlineGoogle Scholar34. Naunyn B: Ueber Ikterus und seine Beziehungen zu den Cholangien, Mitt. a. d. Grenzgeb. d. Med. u. Chir. 31: 537, 1918-19. Google Scholar35. Umber F: Ein Handbuch der inneren Medizin, 1926, L. Mohr and R. Stachelin, J. Springer, Berlin, Band III. Google Scholar36. Siegmund H: Selbständige intrahepatische Cholangitis, Beitr. z. path. Anat. u. z. allg. Path. 87: 425, 1931. Google Scholar37. Frankel E: Ueber Paratyphuserkränkungen besonders des Gallenapparates, München. med. Wchnschr. 65: 523, 1918. Google Scholar38. Bahrman E: Hematogenous cholangitis in septic generalized infections; relation to liver function, Virchows Arch. f. path. Anat. 308: 808, 1942. Google Scholar39. HangerGutman FMAB: Postarsphenamine jaundice apparently due to obstruction of intrahepatic biliary tract, J. A. M. A. 115: 263, 1940. CrossrefGoogle Scholar40. StolzerMillerWhiteZuckerbrod BLGWAM: Postarsenical obstructive jaundice complicated by xanthomatosis and diabetes mellitus, Am. J. Med. 9: 125, 1950. CrossrefGoogle Scholar41. Findlay GM: The experimental production of biliary cirrhosis by salts of manganese, Brit. J. Exper. Path. 5: 92, 1924. Google Scholar42. Eppinger H: Die Leberkrankheiten allgemeine und spezielle Pathologie und Therapie der Leber, 1937, Julius Springer, Wien. Google Scholar43. ChabrolSalletPergolaFallot EJFA: La pénicilline en pathologie biliare et hépatique, Bull. de l'assoc. d'études physiopath. et de la nut. 1: 307, 1947. Google Scholar44. GiraudCazal GP: Cirrhoses biliares et maladie de Hanot (précisions nosologiques à propos de 12 cas études par punction-biopsie), Semaine d. hôp. Paris 23: 2407, 1947. Google Scholar45. CaroliCochin JM: Les hépatites septiques lentes, Paris méd. 38: 245, 1948. MedlineGoogle Scholar46. CattanFremusanCousin RPR: Maladie de Hanot et pénicilline, Semaine d. hôp. Paris 25: 1713, 1949. MedlineGoogle Scholar47. HutchinsonSangsterRandcliffe JARH: Tr. Path. Soc. London 33: 376, 1881-82. Google Scholar48. EpsteinGreenspan EZEB: Clinical significance of cholesterol partition of blood plasma in hepatic and biliary diseases, Arch. Int. Med. 58: 860, 1936. CrossrefGoogle Scholar49. Popper H: Personal communication. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Chicago, Illinois*Received for publication September 7, 1951.From the Departments of Medicine and Pathology, University of Chicago.†Now at the Woodlawn Clinic, 826 East 61st St., Chicago, Ill. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byDie primäre biliäre CirrhosePericholangiolitic biliary cirrhosisPrimary Biliary Cirrhosis: Reevaluation by Clinical and Histologic Study of 49 CasesPRIMARY INTRAHEPatIC CHOLESTASIS IN EARLY INFANCYThe cholestatic form of viral hepatitisIntrahepatic Obstructive JaundiceSerum alkaline phosphatase activity in diseases of the skeletal and hepatobiliary systemsPrimary Biliary CirrhosisThe Physiological Basis for the Surgical Treatment of JaundiceCholangitis und cholangitische HepatopathienIntrahepatic Cholestasis (“Cholangiolitis”)BILIARY CIRRHOSIS IN ADULTS: A STUDY BASED ON NEEDLE BIOPSY OF THE LIVER*†E. R. MOVITT, M.D., F.A.C.P.INTRAHEPATIC OBSTRUCTIVE JAUNDICE (PRIMARY CHOLESTASIS), A CLINICOPATHOLOGIC SYNDROME OF VARIED ETIOLOGY: A REVIEW WITH OBSERVATIONS OF THE USE OF CORTICOTROPIN AS A DIAGNOSTIC TOOL*HENRY C. JOHNSON JR., M.D., JOHN P. DOENGES, M.D.NEEDLE BIOPSY OF THE LIVER: AN APPRAISAL OF ITS DIAGNOSTIC INDICATIONS AND LIMITATIONS*MARTIN S. KLECKNER JR., M.D.Liver disease—Morphologic considerationsNeedle Biopsy of the LiverCirrhosis of the Liver: Natural History of a DiseaseCholangiolitic Biliary Cirrhosis With Short Fatal Course 1 May 1952Volume 36, Issue 5Page: 1241-1277KeywordsBileBile ductsCirrhosisInflammationLesionsPrimary biliary cirrhosis ePublished: 1 December 2008 Issue Published: 1 May 1952 PDF downloadLoading ...