Renal Failure in Cirrhosis—Role of Plasma Volume
Authors: SOLOMON PAPPER
Journal: Annals of Internal Medicine (1968)

Editorial Notes1 April 1968Renal Failure in Cirrhosis—Role of Plasma VolumeSOLOMON PAPPER, M.D., CARLOS A. VAAMONDE, M.D.SOLOMON PAPPER, M.D.Search for more papers by this author, CARLOS A. VAAMONDE, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-68-4-958 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptMany investigators have demonstrated the occurrence of spontaneous, unexplained renal failure in patients with cirrhosis (1, 2). Patients with this syndrome are usually, but not necessarily, severely oliguric and almost invariably die, although death generally cannot be attributed directly to renal failure. At autopsy the kidneys seldom exhibit lesions of proved functional significance and may be entirely normal.The following evidence has strongly indicated a circulatory mechanism in this syndrome: [1] Renal failure may develop rapidly—in months, weeks, or days; [2] the syndrome is often accompanied by a modest reduction in blood pressure; [3] the urine may be concentrated early,...References1. PAPPER S: The role of the kidney in Laennec's cirrhosis of the liver. Medicine (Balt.) 37: 299, 1958. CrossrefMedlineGoogle Scholar2. SHEARKLEINERMANGABUZDA LJGJ: Renal failure in patients with cirrhosis of the liver. I. Clinical and pathologic characteristics. Amer. J. Med. 39: 184, 1965. CrossrefMedlineGoogle Scholar3. KOPPELAGREKOPPLECOBURNMIMSGOLDSTEINBOYLERUBINI MHKLJDJWMMHJDME: Recovery of function in renal homotransplants from donors with hepatorenal syndrome (abstract). Clin. Res. 16: 166, 1968. Google Scholar4. MCCLOYBALDUSTAUXESUMMERSKILL RMWPWNWH: Plasma volume and renal circulatory function in cirrhosis. Ann. Intern. Med. 66: 307, 1967. LinkGoogle Scholar5. REYNOLDSLIEBERMANREDEKER TBFLAG: Functional renal failure with cirrhosis. The effect of plasma expansion therapy. Medicine (Balt.) 46: 191, 1967. CrossrefMedlineGoogle Scholar6. TRISTANICOHN FEJN: Systemic and renal hemodynamics in oliguric hepatic failure: effect of volume expansion. J. Clin. Invest. 46: 1894, 1967. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Department of Medicine The University of New Mexico School of Medicine Albuquerque, N. M. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byHepatorenales SyndromHumorale und hormonale Veränderungen bei portaler HypertonieHepatorenal syndrome: A disease mediated by the intrarenal action of reninLa Sindrome Epato-RenaleNatriuretic hormone--its possible role in fluid and electrolyte disturbances in chronic liver diseaseRecovery from “Hepatorenal Syndrome” after Orthotopic Liver TransplantationSevere hypertension and elevated plasma renin activity following transplantation of “hepatorenal donor” kidneys into anephric recipientsTetracycline-associated fatty liver in the maleRenal failure in the patient with cirrhosis 1 April 1968Volume 68, Issue 4Page: 958-959KeywordsAutopsyBlood pressureCirrhosisKidneysLesionsPlasma volumeRenal failureUrine Issue Published: 1 April 1968 PDF downloadLoading ...