tbuckley/cabot-search huggingface dataset:
Abstract 2205: Exercise Restriction and Sudden Unexpected Death After Balloon Valvuloplasty for Congenital Aortic Stenosis
Authors: David W Brown, Amy E Dipilato, Erin C Chong, Kimberlee Gauvreau, Doff B McElhinney, Steven D Colan, James E Lock
Journal: Circulation (2009)

Background: Exercise restriction is recommended for patients with congenital aortic stenosis (AS) due to a perceived increased risk of sudden unexpected death (SD). However, there is little evidenc...
Update on emergence of HIV-1 resistance to antiretroviral drug classes in an Italian national database: 2007–2009
Authors: S. Di Giambenedetto, M. Prosperi, I. Fanti, B. Bruzzone, S. Paolucci, G. Penco, G. Meini, A. Di Biagio, E. Paolini, V. Micheli, P. Meraviglia, P. Castelli, P. Corsi, A. Gonnelli, M. Fabbiani, M. Zazzi, A. De Luca
Journal: Clinical Microbiology and Infection (2011)
Phagocytic activity and pattern of Fcγ and complement receptors on blood monocytes in pulmonary tuberculosis
Authors: Anna Dubaniewicz, Marlena Smigielska, Piotr Trzonkowski, Jan Marek Slominski
Journal: European Respiratory Journal (2011)

Tuberculosis (TB) remains a worldwide public health problem. Mycobacterium tuberculosis (Mtb) infects approximately one-third of the population. Nearly 8 million active TB cases and 2 million deaths from TB are recorded each year. Majority of Mtb infected individuals control the infection by mounting cell-mediated immune responses but we don9t know why only 5–10% of infected cases develop active TB. Because of CD14, receptors for Fc fragment of IgG (FcγR) and complement (CR) on phagocytes play key role in immune response to Mtb, we have evaluated the expression of receptors FcγRI (CD64), FcγRII (CD32), FcγRIII (CD16) and CR1 (CD35), CR3 (CD11b), CR4 (CD11c) and phagocytic activity of CD14+ monocytes in peripheral blood of 20 patients with TB and 20 healthy volunteers using the flow cytometry. Our study revealed significantly increased presence of receptors CD14+CD32+, CD14+CD35+, and CD14+CD11b+ on monocytes in TB patients than in controls. Analysis of phenotypes both FcγR and CR receptors on CD14+ monocytes revealed significantly increased presence of monocytes CD14+CD64-CD11b+ and CD14+CD16-CD11b+ and insignificant CD14+CD32-CD11b+. Phagocytic activity of blood monocytes in TB patients was significantly higher than in healthy individuals. In summary, increased frequency of CD14+ monocytes with FcγRII, CR1, and CR3 may explain increased adherence and phagocytosis of Mtb with following development of TB. Therefore, the receptors FcγRII and CR1, CR3 could be considered as drug target for treatment of TB.
Selective Inhibition of Respiration of Pigmented S91 Mouse Melanomas by Phenyl Lactate, and the Possibly Related Effects on Growth&lt;xref ref-type="fn" rid="FN1"&gt;2&lt;/xref&gt;
Authors: H B DEMOPOULOS, G KALEY
Journal: JNCI Journal of the National Cancer Institute (1963)

Journal Article Selective Inhibition of Respiration of Pigmented S91 Mouse Melanomas by Phenyl Lactate, and the Possibly Related Effects on Growth Get access Harry B. Demopoulos, Harry B. Demopoulos Search for other works by this author on: Oxford Academic PubMed Google Scholar Gabor Kalley Gabor Kalley Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 30, Issue 3, March 1963, Pages 611–633, https://doi.org/10.1093/jnci/30.3.611 Published: 01 March 1963 Article history Received: 26 November 1962 Published: 01 March 1963
A technique for dating toxoplasmosis in pregnancy and comparison with the Vidas anti-toxoplasma IgG avidity test
Authors: P. Flori, B. Bellete, C. Crampe, A. Maudry, H. Patural, C. Chauleur, J. Hafid, H. Raberin, R. Tran Manh Sung
Journal: Clinical Microbiology and Infection (2008)
PAROXYSMAL AURICULAR FIBRILLATION IN ASSOCIATION WITH HIATUS HERNIA; REPORT OF A CASE
Authors: William D. Stubenbord
Journal: Annals of Internal Medicine (1943)

Case Reports1 March 1943PAROXYSMAL AURICULAR FIBRILLATION IN ASSOCIATION WITH HIATUS HERNIA; REPORT OF A CASEWILLIAM D. STUBENBORD, M.D.WILLIAM D. STUBENBORD, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-18-3-406 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptParoxysmal auricular fibrillation has been described many times. The inciting factors are numerous, varied, and often difficult to determine. This arrhythmia may take place in the presence of organic heart disease as well as in hearts which show no variation from the normal. Not infrequently, the inciting factor is due to alcoholic drinking or to some gastrointestinal disorder.The association of hiatus hernia with heart disturbances is now well established. Harrington,1in a review of 60 cases of hiatus hernia, had seven cases which were diagnosed as heart disease. Recently, Gilbert2stated that hiatus hernia may induce attacks of paroxysmal...Bibliography1. HARRINGTON SW: Diaphragmatic hernia, Jr. Am. Med. Assoc., 1933, x, 987-994. CrossrefGoogle Scholar2. GILBERT NC: Influence of extrinsic factors on the coronary flow and clinical course of heart disease, Bull. New York Acad. Med., 1942, 83-91. MedlineGoogle Scholar3. LEVY RL: Auricular fibrillation with regular ventricular rhythm and rate over sixty, Arch. Int. Med., 1926, xxxviii, 116-128. CrossrefGoogle Scholar4. LEWIS WH: Anatomy of the human body, by H. GRAY, 1936, Lea & Febiger, Philadelphia, xxiii, 900-904. Google Scholar5. JACKSON CM: Morris's human anatomy, 1914, P. Blakiston Co., Philadelphia, v, 954-958. Google Scholar6. BRILL IC: Auricular fibrillation; the present status with a review of the literature, ANN. INT. MED., 1937, x, 1487-1502. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: New York, N. Y.*Received for publication June 8, 1942. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 March 1943Volume 18, Issue 3Page: 406-409KeywordsAlcoholicsArrhythmiaAtrial fibrillationCardiovascular therapyHeartHernia ePublished: 1 December 2008 Issue Published: 1 March 1943 PDF downloadLoading ...
NEDD8 Inhibition Overcomes CKS1B-Induced Drug Resistance by Upregulation of p21 in Multiple Myeloma
Authors: Junwei Huang, Yi Zhou, Gregory S. Thomas, Zhimin Gu, Ye Yang, Hongwei Xu, Guido Tricot, Fenghuang Zhan
Journal: Clinical Cancer Research (2015)

CKS1B is significantly upregulated in multiple myeloma and associated with poor prognosis. The identification of novel therapies is essential for effective treatment of patients resistant to chemotherapy. The NEDD8 inhibitor MLN4924 selectively targets SCF(Skp2) activation and offers a more specific approach to protein degradation inhibition than total proteasomal inhibition. The goal of this study was to evaluate whether MLN4924 is effective in high CKS1B conditions and identify mechanisms regulating drug potency.Bortezomib and MLN4924 sensitivity was assessed through proliferation, viability, clonogenic potential, and senescence induction in cells overexpressing CKS1B. The mechanism for MLN4924 sensitivity was elucidated by immunoblot analysis of SCF(skp) substrates and confirmed by shRNA knockdown. The clinical relevance of the NEDD8 pathway was examined in gene expression profiles (GEP) derived from healthy people, patients with monoclonal gammopathy of undetermined significance (MGUS), and multiple myeloma.Cells overexpressing CKS1B were resistant to bortezomib but sensitive to MLN4924. Treatment of CKS1B-overexpressing cells with MLN4924 decreased proliferation, clonogenicity, and induced senescence. MLN4924, but not bortezomib, induced stabilization of p21 and knockdown of p21 resulted in loss of MLN4924 sensitivity. Patients with MGUS and multiple myeloma exhibited increased expression of NEDD8 pathway genes relative to normal plasma cells. Multiple myeloma patients with high NEDD8 expression were linked to bortezomib resistance in clinical trials, and had inferior outcomes.Our data demonstrate that cells with elevated CKS1B expression are resistant to bortezomib but sensitive to MLN4924 and offer a mechanism through the stabilization of p21. These findings provide rationale for targeting the NEDD8 pathway in multiple myeloma patients exhibiting elevated expression of CKS1B. Clin Cancer Res; 21(24); 5532-42. ©2015 AACR.
Long-term cyclosporine therapy for pediatric nephrotic syndrome
Authors: M J Gregory, W E Smoyer, A Sedman, D B Kershaw, R P Valentini, K Johnson, T E Bunchman
Journal: Journal of the American Society of Nephrology (1996)

Cyclosporine (CsA) is effective in treating steroid-dependent (SDNS) and steroid-resistant (SRNS) nephrotic syndrome (NS) in children, but because of the potential for chronic nephrotoxicity, its long-term use is controversial. This study reports the results of long-term CsA treatment in 22 children with idiopathic NS. Indications for treatment included SDNS (N = 7) and SRNS (N = 15) children. Pre-CsA histology showed minimal change disease in three patients, immunoglobulin M nephropathy (IgM) in 14 patients, and focal segmental glomerulosclerosis (FSGS) in five patients. All patients had normal initial serum creatinine values. CsA was added to prednisone at 6.3 +/- 0.4 mg/kg per day (mean +/- SE) and adjusted to maintain whole blood trough HPLC levels of 70 to 120 ng/mL for a period of 6 to 53 months (mean, 22 months). Analysis by clinical course revealed that 13 of 15 patients with SRNS (87%) entered remission after a mean duration of CsA treatment of 58 days, whereas seven of seven patients with SDNS were able to be weaned off of daily prednisone therapy. Histologic analysis showed that all five patients with FSGS and 13 of 14 patients with IgM nephropathy either entered remission or were weaned off of daily steroids. Ten of the 22 patients (45%) with complete remission required CsA plus low-dose alternate-day prednisone to maintain remission. Hypertension was seen in eight of 22 patients (36%). No patient had a significant increase in serum creatinine concentration. Renal biopsies performed in 12 patients after 12 to 41 months (mean, 21 months) of CsA therapy showed no nephrotoxicity or disease progression in ten patients. Progression of the previous interstitial fibrosis and tubular atrophy was noted in two patients, suggesting a 17% incidence of CsA nephrotoxicity. This analysis of the long-term risks and benefits of CsA for childhood NS has identified two important findings: (1) combined CsA and alternate-day steroids can be highly effective in inducing complete remission in patients with SRNS and biopsy-proven IgM nephropathy, and (2) long-term use of CsA in moderate doses with closely monitored levels can result in a relatively low incidence of nephrotoxicity.
Formoterol and fluticasone reduce the deposition of pro-inflammatory collagens
Authors: Michael Roth, Jun Zhong, Chong Teck S'ng, Michael Tamm
Journal: European Respiratory Journal (2012)

Background: Increased deposition pro-inflammatory collagen I and III has been shown in the sub-epithelial airways in asthma. Formoterol has been reported to reduce collagen deposition, while steroid action depends on the presence of inflammation. Under inflammatory condition, steroids increased collagen deposition.

Objective: We investigated the effect of three steroids on the inhibitory effect of formoterol on collagen deposition in TGF-β1 and serum stimulated human airway smooth muscle (ASM) cells.

Methods: ASM cells were incubated for 3 days with serum (5%) or TGF-β1 (1ng/ml) in the presence or absence of formoterol, dexamethasone, budesonide or fluticasone (1nM – 1microM). Collagen deposition was determined by an in house ELISA.

Results: Serum and TGF-β1 significantly increased the deposition of collagen I and III, while they did not affect the collagen IV content. In non-stimulated cells, all 3 steroids reduced the deposition of collagen I and III dose dependently, while they increased collagen IV. In stimulated cells (TGF-β1, serum) collagen I and III deposition were further increased. Formoterol dose dependently reduced the deposition of all three collagens in non-stimulated and stimulated cells. When combined with steroids the inhibitory of formoterol on collagen I and III deposition was dose dependently increased, but had no effect on collagen IV. The combination with fluticasone achieved more often a stronger inhibitory effect than the other 2 steroids. Conclusion : Our data suggests that formoterol has the potential to reduce airway wall remodelling in asthma and in combination with fluticasone, it is more effective than with other steroids.
Overexpression of Pro-Osteoclastogenic Cytokine Receptors and Chemokines By Bone Marrow CD14+ Monocytes of Multiple Myeloma (MM) Patients As Compared to Smoldering MM (SMM) and Monoclonal Gammopathy of Uncertain Significance (MGUS): Role of Interleukin(IL)-21 Receptor/IL-21 Axis in MM-Induced Osteoclastogenesis
Authors: Marina Bolzoni, Domenica Ronchetti, Paola Storti, Daniela Guasco, Valentina Marchica, Luca Agnelli, Benedetta Dalla Palma, Fabrizio Accardi, Federica Costa, Denise Toscani, Sabrina Bonomini, Benjamin Thomas, Antonino Neri, Franco Aversa, Nicola Giuliani
Journal: Blood (2014)
Interleukin 12–dependent Interferon γ Production by CD8α+Lymphoid Dendritic Cells
Authors: Toshiaki Ohteki, Taro Fukao, Kazutomo Suzue, Chikako Maki, Mamoru Ito, Masataka Nakamura, Shigeo Koyasu
Journal: The Journal of Experimental Medicine (1999)

We investigated the role of antigen-presenting cells in early interferon (IFN)-γ production in normal and recombinase activating gene 2–deficient (Rag-2−/−) mice in response to Listeria monocytogenes (LM) infection and interleukin (IL)-12 administration. Levels of serum IFN-γ in Rag-2−/− mice were comparable to those of normal mice upon either LM infection or IL-12 injection. Depletion of natural killer (NK) cells by administration of anti-asialoGM1 antibodies had little effect on IFN-γ levels in the sera of Rag-2−/− mice after LM infection or IL-12 injection. Incubation of splenocytes from NK cell–depleted Rag-2−/− mice with LM resulted in the production of IFN-γ that was completely blocked by addition of anti–IL-12 antibodies. Both dendritic cells (DCs) and monocytes purified from splenocytes were capable of producing IFN-γ when cultured in the presence of IL-12. Intracellular immunofluorescence analysis confirmed the IFN-γ production from DCs. It was further shown that IFN-γ was produced predominantly by CD8α+ lymphoid DCs rather than CD8α− myeloid DCs. Collectively, our data indicated that DCs are potent in producing IFN-γ in response to IL-12 produced by bacterial infection and play an important role in innate immunity and subsequent T helper cell type 1 development in vivo.
The Activation Function-1 of Estrogen Receptor Alpha Prevents Arterial Neointima Development Through a Direct Effect on Smooth Muscle Cells
Authors: Natalia F. Smirnova, Coralie Fontaine, Mélissa Buscato, Adrien Lupieri, Alexia Vinel, Marie-Cécile Valera, Maeva Guillaume, Nicole Malet, Jean-Michel Foidart, Isabelle Raymond-Letron, Francoise Lenfant, Pierre Gourdy, Benita S. Katzenellenbogen, John A. Katzenellenbogen, Muriel Laffargue, Jean-Francois Arnal
Journal: Circulation Research (2015)

17β-Estradiol (E2) exerts numerous beneficial effects in vascular disease. It regulates gene transcription through nuclear estrogen receptor α (ERα) via 2 activation functions, AF1 and AF2, and can also activate membrane ERα. The role of E2 on the endothelium relies on membrane ERα activation, but the molecular mechanisms of its action on vascular smooth muscle cells (VSMCs) are not fully understood.The aim of this study was to determine which cellular target and which ERα subfunction are involved in the preventive action of E2 on neointimal hyperplasia.To trigger neointimal hyperplasia of VSMC, we used a mouse model of femoral arterial injury. Cre-Lox models were used to distinguish between the endothelial- and the VSMC-specific actions of E2. The molecular mechanisms underlying the role of E2 were further characterized using both selective ERα agonists and transgenic mice in which the ERαAF1 function had been specifically invalidated. We found that (1) the selective inactivation of ERα in VSMC abrogates the neointimal hyperplasia protection induced by E2, whereas inactivation of endothelial and hematopoietic ERα has no effect; (2) the selective activation of membrane ERα does not prevent neointimal hyperplasia; and (3) ERαAF1 is necessary and sufficient to inhibit postinjury VSMC proliferation.Altogether, ERαAF1-mediated nuclear action is both necessary and sufficient to inhibit postinjury arterial VSMC proliferation, whereas membrane ERα largely regulates the endothelial functions of E2. This highlights the exquisite cell/tissue-specific actions of the ERα subfunctions and helps to delineate the spectrum of action of selective ER modulators.
Nilotinib Exerts Direct Pro-Atherogenic and Anti-Angiogenic Effects On Vascular Endothelial Cells: A Potential Explanation For Drug-Induced Vasculopathy In CML
Authors: Hadzijusufovic Emir, Karin Albrecht-Schgoer, Kilian Huber, Florian Grebien, Gregor Eisenwort, Wilfried Schgoer, Christoph Kaun, Susanne Herndlhofer, Markus Theurl, Sabine Cerny-Reiterer, Gregor Hoermann, Wolfgang R Sperr, Rix Uwe, Johann Wojta, Dominik Wolf, Giulio Superti-Furga, Rudolf Kirchmair, Peter Valent
Journal: Blood (2013)
Underlying clinical conditions and invasive pneumococcal disease (IPD) in adults in Spain (ODIN study, 2010-2012)
Authors: Antoni Torres, Marta Rodríguez-Créixems, Inmaculada Grau, Luis Molinos, Pedro Llinares, José Luis De la Cruz, Olga Rajas, Inmaculada Alfageme, Miguel Salavert, Asunción Fenoll, Josefina Liñares, Isabel Cifuentes
Journal: European Respiratory Journal (2013)

Background: Some underlying clinical conditions are known to increase the risk of IPD in adults.

Objectives: This study aimed to explore medical conditions by age group and previous vaccination history in adults with IPD.

Methods: Prospective surveillance of culture-confirmed IPDs in adults (≥18 years) performed in 9 Spanish hospitals (August 2010-June 2012).

Results: 436 cases (mean age 62.7;17.4 years; 58.7% males) were included. No differences were seen in immune status or underlying diseases with respect to age (62.0;16.3 and 63.2;18.1 in immunocompromised and inmunocompetent patients, respectively; p=0.30; 63.1;16.9 and 58.7;20.7 in patients with ≥1 and without underlying conditions, respectively; p=0.18). The most frequent clinical presentation was invasive pneumonia (303; 69.5%). 19% had received polysaccharide pneumococcal vaccine (PPV). No differences were found in the outcome according to PPV vaccination history. Case fatality rate was 13.3% and 40% in severe sepsis. Table shows comorbidities by age group.

![Figure][1] 



Conclusions: The high frequency of IPD cases in patients with chronic respiratory disease and/or smoking supports the need for a new approach in the management of these underlying conditions. Facing limitations of PPV, vaccination with PCV13 could be a better strategy.

This study was sponsored by Pfizer.

 [1]: pending:yes
Tumor Control and Pulmonary Metastasis in Fractionally Irradiated Transplanted Mammary Carcinoma in C3H Mice&lt;xref ref-type="fn" rid="FN2"&gt;2&lt;/xref&gt;&lt;xref ref-type="fn" rid="FN3"&gt;3&lt;/xref&gt;
Authors: H G Seydel, K W Sloan, W McCready
Journal: JNCI Journal of the National Cancer Institute (1972)
Heterogeneity of disease and clones of community-onset methicillin-resistant Staphylococcus aureus in children attending a paediatric hospital in Belgium
Authors: A. Vergison, A. Nobre Machado, A. Deplano, M. Doyen, J. Brauner, C. Nonhoff, R. de Mendonça, G. Mascart, O. Denis
Journal: Clinical Microbiology and Infection (2011)
Impact of cyclophosphamide on relationships between carboplatin exposure and response or toxicity when used in the treatment of advanced ovarian cancer.
Authors: L M Reyno, M J Egorin, R M Canetta, D I Jodrell, K D Swenerton, J L Pater, J N Burroughs, M J Novak, R Sridhara
Journal: Journal of Clinical Oncology (1993)

PURPOSE To determine (1) the impact of cyclophosphamide 600 mg/m2 on previously defined relationships between carboplatin area under the plasma concentration versus time curve (AUC) and indices of toxicity and response in women with advanced ovarian cancer; and (2) the relationships between indices of cumulative drug exposure and clinical outcomes. METHODS Carboplatin AUC = dose/(creatinine clearance [CCr] + 25) and was calculated in 224 women who received carboplatin 300 mg/m2 and cyclophosphamide 600 mg/m2. The likelihood of grade 3 or greater myelotoxicity at any carboplatin AUC was compared with the likelihood of myelotoxicity at the same single-agent carboplatin AUC. The nadir count predicted using the University of Maryland single-agent carboplatin dosing formula was compared with the nadir count observed. Received and relative-received dose-intensity were calculated. Carboplatin exposure-intensity was defined by substituting cumulative carboplatin exposure for total dose. Relationships were sought between these indices and therapeutic outcomes. RESULTS The incidence of leukopenia and thrombocytopenia at any carboplatin AUC was greater for the two-drug combination than for single-agent carboplatin. The platelet nadir in 83% of patients was less than or equal to the nadir predicted for the same single-agent carboplatin AUC. Despite a narrow range of received dose-intensities, carboplatin exposure-intensity was distributed over a twofold range. There were no relationships between received and relative-received dose-intensity or carboplatin exposure-intensity and time to progression or survival. CONCLUSION Any carboplatin AUC when administered with cyclophosphamide 600 mg/m2 produces greater myelotoxicity than the same AUC of single-agent carboplatin. Received carboplatin dose-intensity underestimates the range of plasma drug exposure resulting from a fixed carboplatin dosing regimen. Whether higher carboplatin exposures can improve outcome requires prospective validation.
Memory Self-Appraisal in Middle-Aged and Older Adults With the Apolipoprotein E-4 Allele
Authors: Gary W. Small, Stephen T. Chen, Scott Komo, Linda Ercoli, Susan Bookheimer, Karen Miller, Helen Lavretsky, Sanjaya Saxena, Andrea Kaplan, Deborah Dorsey, William K. Scott, Ann M. Saunders, Jonathan L. Haines, Allen D. Roses, Margaret A. Pericak-Vance
Journal: American Journal of Psychiatry (1999)

Because subjective memory complaints may indicate subtle functional brain abnormalities, the authors studied the influence of the major genetic risk for Alzheimer's disease, the apolipoprotein E-4 (APOE-4) allele, on self-reports of memory performance in middle-aged and older adults.Subjective and objective assessments of memory performance were compared in relation to the presence or absence of the APOE-4 allele in 39 cognitively intact persons with mild memory complaints.Subjects with the APOE-4 allele had lower scores on objective verbal memory and on the subjective memory measure for retrospective functioning. Among the subjects in the age range where APOE-4 has its greatest influence on the risk of Alzheimer's disease (55-74 years), the APOE-4 group had lower scores on the subjective memory measure for frequency of forgetting. Moreover, the standardized difference in retrospective functioning scores between the two genetic risk groups increased when the mid-age-range group was examined rather than the whole study group.The APOE-4 allele is associated with increased subjective memory impairment in middle-aged and older adults. Longitudinal studies of age-related memory loss should include genetic risk and subjective memory measures as potential predictors of decline.