tbuckley/cabot-search huggingface dataset:
WHAT THE PHYSICIAN SHOULD KNOW ABOUT DENTAL PROBLEMS
Authors: Wm. J. Kerr
Journal: Annals of Internal Medicine (1936)

Article1 September 1936WHAT THE PHYSICIAN SHOULD KNOW ABOUT DENTAL PROBLEMSWM. J. KERR, M.D., F.A.C.P.WM. J. KERR, M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-10-3-386 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptIt is indeed an auspicious occasion which brings together the dentist and the physician. They have too long traveled independent courses to the detriment of each. The schism which led to the development of modern dentistry is so recent that most of us can recall the family doctor who practiced dentistry as a "side line." His efforts were directed chiefly toward the relief of pain in an aching tooth. When he failed in this, the ever ready forceps in his medical kit came into action. The village blacksmith was also handy with his tongs or with the punch and a... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: San Francisco, California*Read before the Pacific Coast Dental Conference, July 1935. Received for publication April 25, 1936.From the Dept. of Medicine, University of California Medical School, San Francisco. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byRelationship Between Dental and Cardiovascular Disease 1 September 1936Volume 10, Issue 3Page: 386-394KeywordsDentistry Issue Published: 1 September 1936 PDF downloadLoading ...
Pitfalls of Converting Practice Guidelines Into Quality Measures
Authors: Greg Pawlson, Sarah Hudson Scholle, Philip Renner
Journal: JAMA (2004)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
707. Retroviral Insertion Site Analysis in Rhesus Macaques Transplanted with CD34+ Hematopoietic Stem Cells Transduced with a Simian Immunodeficiency Virus-Based Lentiviral Vector
Authors: Manfred Schmidt, Jingjong Hu, Salima Hacein-Bey-Abina, Alain Fischer, Manuela Wissler, Claudia Prinz, Hanno Glimm, Kerstin Schwarzwaelder, Francoise LeDeist, Alexandrine Garrigue, Isabelle Andre-Schmutz, Marina Cavazzana-Calvo, Christof von Kalle
Journal: Molecular Therapy (2004)

Two children involved in the successful retroviral gene therapy clinical trial of SCID-X1 (2 year survival: 100%, FFTF 60%) developed a malignant T-cell lymphoproliferation 34 months after treatment. In both cases, vector integration into the vicinity of exon 1 of the protooncogene LMO2 occured (Hacein-Bey-Abina, 2003). The potential for unwanted side effects from retroviral insertional mutagenesis is now a focus of biosafety considerations in gene transfer using integrating vector systems. Several groups could show that gene coding areas, in particular transcription start sites, are preferred insertion loci (Schroder, 2002; Wu, 2003). While these studies mapped a great number of integration sites with statistical significance, they were limited to in vitro gene transfer into nonhematopoietic human cell lines. As T cells do not grow in these cases unless they express the gamma c chain, we reasoned that there may be selection pressure on the retrovirus integration site distribution. Using a highly sensitive and specific linear amplification mediated PCR (LAM-PCR), we analyzed DNA samples from 8 patients enrolled in the X-SCID gene therapy trial. We could perform successive insertion site analysis and subsequently identify more than 400 integration sites after transplantation. In all patient samples examined, a stable polyclonal profile demonstrated polyclonal hematopoietic repopulation. To distinguish the influence of required transgene expression on retrovirus integration site distribution, we analyzed insertion sites in patient CD34+ cells prior to autologous transplantation, shortly after ex vivo transduction. More than 100 integration sites present prior to transplantation could be identified for comparative pre-/post-tranplantation analysis. No obvious difference in insertion site distribution could be detected between pre- and post-transplant samples form a first analysis. However, our data indicate that X-SCID correction, which depends on transgene expression, favors chromosomal locations associated with active transciption. We conclude that the distribution of retrovirus integration sites can be assessed by random sampling in a clinical trial setting and may differ significantly from previously published assumptions, especially in settings of selective advantage related to transgene expression.
A Computerized Summary Medical Record System Can Provide More Information Than the Standard Medical Record
Authors: Quinn E. Whiting-O'Keefe
Journal: JAMA (1985)

We assessed the ability of a computerized outpatient medical record (MR) system, the Summary Time-Oriented Record (STOR), to communicate information to clinicians in two randomized single-blind studies. In the first study, physicians were better able to predict their patients' future symptom changes and laboratory test results from outpatient visits to an arthritis clinic when STOR was added to the standard MR than when the standard MR was used alone. In a separate study, the removal of the standard MR did not result in important decrease in the physicians' ability to predict their patients' symptoms and laboratory test results if they had the option of using the full paper record when they thought they needed it. In 134 (26%) of 514 visits, the physicians exercised this option. We conclude that for outpatient visits, the computerized record system STOR operationally added information to that supplied by the full paper MR. This improved flow of information could improve the clinical decision process.
Scrofula and the Divine Right of Royalty
Authors: Fleta N. Bray, Mohammed Alsaidan, Brian J. Simmons, Leyre Ainara Falto-Aizpurua, Keyvan Nouri
Journal: JAMA Dermatology (2015)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Dermatology HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Dermatology journal
Russian Klebsiella pneumoniae isolates that express extended-spectrum β-lactamases
Authors: P.L. Winokur, M.V. Eidelstain, O. Stetsiouk, L. Stratchounski, J. Blahova, G.K. Reshedko, M.A.T. Croco, R.J. Hollis, M.A. Pfaller, R.N. Jones, R.N. Jones
Journal: Clinical Microbiology and Infection (2000)
817. Nonrandom Insertion Site Preferences for the SB Transposon In Vitro and In Vivo
Authors: Stephen R. Yant, Xiaolin Wu, Yong Huang, Bernie Daigle, Brian A. Garrison, Shawn M. Burgess, Mark A. Kay
Journal: Molecular Therapy (2004)

The recent demonstration that HIV-1, MLV, and AAV all strongly favor integration into active genes has raised significant concerns about the future of gene insertion-based therapies. The Sleeping Beauty (SB) transposon has shown tremendous success in preclinical gene therapy models and is a promising alternative to viral-based in vivo delivery methods, and herein, we investigated its target site preferences. Using a plasmid rescue strategy, we isolated 524 unique, unselected transposition events from adult mouse liver and compared the chromosomal features associated with these coordinates with 10,000 computer-simulated random integrations. SB insertions were distributed evenly on each chromosome, but were highly favored in 2-6 bp simple sequence repeats (p < 0.0001) and were strongly disfavored in genomic LINEs (p < 0.0001). Also, SB showed a marked preference for integration into localized AT-rich palindromes, especially the consensus sequence GNATATATANC (p < 0.01). These attributes are consistent with a bendable target DNA structure and suggest a two-fold dyad symmetry at the insertion site. We also mapped SB insertions with respect to the RefSeq genes defined by the UCSC mouse genome database. Results showed that ~20% (103/524) of transposon insertions mapped within at least one RefSeq gene, which was not statistically different from the control set (p=0.3). These intragenic insertions were distributed evenly along the transcripts without orientational preference, but were almost exclusively within introns. Interestingly, all five of the exon insertions we isolated were in the reverse orientation of transcription and all mapped near the 3′ end of genes, very close to the translational stop site. Moreover, even though SB does not appear to actively target intragenic regions, it showed a weak but significant tendency to insert upstream of genes (p=0.009), especially ± 5 kb of the transcriptional start site (p < 0.005) and within known CpG islands (p=0.0001). We therefore analyzed an Affymetrix chip dataset available on the web to test whether preferences for promoter regions might be due in part to transcriptional activity. However, results showed no statistical difference between the 44 SB-targeted and 70 randomly-targeted RefSeq genes represented on the array (p=0.25), suggesting that chromatin accessibility, rather than active tethering, may be involved in SB's regional insertion site preferences. Currently, we are analyzing a large number of insertions from mouse and human cell lines in order to test the generality of these preferences in different tissues and/or species, and are determining whether or not genetic selection introduces any bias during SB insertion site selection. Collectively, these data demonstrate a nonrandom distribution for SB insertions in mammals, and suggest that SB integration may be significantly safer for stable in vivo gene delivery than many widely used viral-based vectors.
Balanced translocation t(11;15)(q23;q15) in a P53+/+ breast cancer patient from a Li-Fraumeni Syndrome family
Authors: Zaki A. Sherif, Mark Danielsen
Journal: Cancer Research (2006)

4207  Li-Fraumeni Syndrome (LFS) is characterized by early-onset carcinogenesis involving multiple tumor types with autosomal dominant inheritance. Approximately 70% of LFS cases are due to germline mutations in the p53 gene on chromosome 17p13.1. Mutations have also been found in the CHK2 gene on chromosome 22q11 and others have been mapped to chromosome 11q23. While characterizing an LFS family with a documented defect in p53, we found one that developed bilateral breast cancer at age 37 yet was homozygous for wild-type P53. Her mother also developed early-onset primary bilateral breast cancer while a sister had unilateral breast cancer and a soft tissue sarcoma. Cytogenetic analysis using fluorescence in situ hybridization of a primary skin fibroblast cell line revealed that the patient had a novel balanced reciprocal translocation between the long arms of chromosomes 11 and 15. This translocation t(11;15)(q23;q15) was not present in a primary skin fibroblast cell line from a brother with neuroblastoma, who was heterozygous for the p53 mutation. There was no evidence of acute lymphoblastic leukemia in either the patient or her mother although a nephew did develop leu kemia and died in childhood. These data implicate the region at breakpoint 11q23 and/or 15q15 as playing a significant role in predisposition to breast cancer development.
Confidentiality and Privacy of Electronic Medical Records
Authors: L Lamberg
Journal: JAMA (2001)

NEW ORLEANS—Starting with a birth date, sex, and ZIP code, computer privacy expert Latanya Sweeney, PhD, retrieved health data of William Weld, former governor of Massachusetts, from an allegedly anonymous database of state employee health insurance claims. Knowing Weld lived in Cambridge, Mass, she cross-linked her data with that community’s publicly available voter registration records. Only six people shared Weld’s birth date. Only three were men. Of these, Weld was the only man in his five-digit ZIP code. Sensitive information can be obtained with standard office computer software, without resorting to hacking, said Sweeney, founder and director of the Laboratory for International Data Privacy at Carnegie Mellon University, Pittsburgh. Removing names and social security numbers doesn’t ensure privacy, she said. Birth date, sex, and ZIP code alone uniquely identify 87% of the US population. Sweeney and others explored confidentiality and medical record privacy in the 21st century in a forum at the annual meeting of the American Psychiatric Association (APA) here in May. People who see psychiatrists must feel secure that their revelations will remain private, said outgoing APA president Daniel Borenstein, MD, session chair. “In the Internet age,” he said, “some wonder if privacy exists.” Borenstein, a private practitioner in Los Angeles, is clinical professor of psychiatry and biobehavioral sciences at the University of California, Los Angeles, School of Medicine. NEW PRIVACY REGULATIONS
Medical vs Surgical Management of Left Main Coronary Artery Disease—Reply
Authors: Joseph P. Carrozza, Frank W. Sellke
Journal: JAMA (2005)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The firewater myth and response to alcohol in Mission Indians
Authors: C Garcia-Andrade, T L Wall, C L Ehlers
Journal: American Journal of Psychiatry (1997)

This study aimed to assess empirically the intensity of reaction to alcohol in a group of Native Americans.Forty healthy, nonalcoholic Mission Indian men between the ages of 18 and 25 years were tested before and after ingestion of placebo and 0.75 ml/kg of alcohol. Subjective (self-report of feelings) and objective (blood pressure, pulse rate, and plasma cortisol level) measures of intoxication were taken before ingestion of alcohol and placebo and at 15, 30, 60, 90, and 120 minutes after ingestion. Overall effects of alcohol were evaluated, and the responses of subjects with less than 50% Native American heritage (N = 19) were compared with the responses of subjects with at least 50% Native American heritage (N = 21).Alcohol did not produce any significant effects on any of the objective measures of intoxication; however, the subjects reported significant subjective effects of alcohol. Subjects with at least 50% Native American heritage reported less intense effects of alcohol than did those with less than 50% Native American heritage, despite equivalent blood alcohol concentrations.These results contradict the "firewater myth"--the theory that Native Americans are more sensitive to the effects of alcohol. Rather, the data indicate that Mission Indian men generally may be less sensitive to alcohol's effects, a physiological characteristic that has been shown to be associated with a greater risk for alcoholism in Caucasian populations. In addition, individuals with a greater percentage of Native American heritage may be less sensitive to the subjective effects of alcohol than individuals with a smaller percentage of Native American heritage.
Abstract B19: Discovery of novel tubulin inhibitor ABI-274 whose synergistic combination with vemurafenib overcome acquired vemurafenib resistance in BRAF mutated melanoma
Authors: Jin Wang, Jianjun Chen, Duane D. Miller, Wei Li
Journal: Cancer Research (2015)

Abstract Acquired clinical resistance to BRAF inhibitors such as vemurafenib or dabrafefnib arises frequently after short term of these targeted therapy. We hypothesized that a combined therapy using vemurafenib with a G2/M phase blocking agent will arrest resistant cells and overcome vemurafenib resistance. To test this hypothesis, we performed combination studies using our recently discovered tubulin inhibitor ABI-274 and vemurafenib on both vemurafenib-sensitive cells and a resistant A375RF21 sub line. The combination showed strong synergy in vitro, synergistically arrested cells in G1/G2/M phase, and significantly enhanced cancer cell apoptosis. In vivo co-administration of vemurafenib with ABI-274 showed strong synergistic efficacy in the vemurafenib-resistant xenograft model in nude mice. Overall, these results offer a rational combination strategy to significantly enhance the therapeutic benefit in melanoma patients who inevitably become resistant to current vemurafenib therapy. This work was supported by NIH grants R01CA148706, 1S10OD010678-01 and 1S10RR026377-01. Citation Format: Jin Wang, Jianjun Chen, Duane D. Miller, Wei Li. Discovery of novel tubulin inhibitor ABI-274 whose synergistic combination with vemurafenib overcome acquired vemurafenib resistance in BRAF mutated melanoma. [abstract]. In: Proceedings of the AACR Special Conference on Advances in Melanoma: From Biology to Therapy; Sep 20-23, 2014; Philadelphia, PA. Philadelphia (PA): AACR; Cancer Res 2015;75(14 Suppl):Abstract nr B19.
A Difference of Degrees
Authors: Martin J Stillman
Journal: JAMA (2003)

Medical SpecialtiesF uture physicians go to medical school after they complete college.Medical students learn about many different areas of medicine, including those designated as specialties.At the end of medical school, doctors choose the specialty in which they will have more education and eventually practice.Education in each specialty takes three to seven years of a residency after medical school.Some medical specialties have subspecialties that require even more education and training.Since medical knowledge is so complex and advanced, most doctors limit their practices to their area of specialization.The September 3, 2003, issue of JAMA, a theme issue on medical education, includes articles on medical specialties.
Agonist-Induced Regulation of Myosin Phosphatase Activity in Human Platelets Through Activation of Rho-Kinase
Authors: Yoshinori Suzuki, Masatoshi Yamamoto, Hideo Wada, Masaaki Ito, Takeshi Nakano, Yasuharu Sasaki, Shuh Narumiya, Hiroshi Shiku, Masakatsu Nishikawa
Journal: Blood (1999)
Abstract 17445: Overexpression of Adenylyl Cyclase Type 5 (AC5) in the Heart Predisposes to Cardiac Arrhythmias
Authors: Zhenghang Zhao, Gopal J Babu, Nadezhda Fefelova, Yoshihiro Ishikawa, Kousaku Iwatsubo, Lo Lai, Lin Yan, Dorothy E Vatner, Stephen F Vatner, Lai-Hua Xie
Journal: Circulation (2010)

Adenylyl cyclase type 5 (AC5) is one of two major AC isoforms in the heart. It is controversial whether AC5 overexpression (AC5 OE) in the heart is protective or deleterious, particularly related t...
Implications of Disclosing Individual Results of Clinical Research
Authors: Ellen Wright Clayton, Lainie Friedman Ross
Journal: JAMA (2006)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Simultaneous single-tube PCR assay for the detection of Neisseria meningitidis, Haemophilus influenzae type b and Streptococcus pneumoniae
Authors: G. Tzanakaki, M. Tsopanomichalou, K. Kesanopoulos, R. Matzourani, M. Sioumala, A. Tabaki, J. Kremastinou
Journal: Clinical Microbiology and Infection (2005)