Drug Therapy and the Etiology of Systemic Lupus Erythematosus
Authors: HOWARD L. HOLLEY
Journal: Annals of Internal Medicine (1961)

Editorials1 December 1961Drug Therapy and the Etiology of Systemic Lupus ErythematosusHOWARD L. HOLLEY, M.D., F.A.C.P.HOWARD L. HOLLEY, M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-55-6-1036 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptAlthough many theories concerning the cause of lupus erythematosus (SLE) have been advanced, the precise etiology of this disorder remains obscure. Most investigators now believe that the symptomatology and ultimate pathology in this condition are attendant upon an abnormal hypersensitivity state. Evidence for this concept is the occurrence of antibody activity in a variety of plasma proteins to various cell types of the human body during the course of the disease (1). Although these antibodies vary from patient to patient, their appearance and disappearance are related to the activity and inactivity, respectively, of the disease process (2).Reports of the...References1. HOLMAN H: Systemic lupus erythematosus: a review of certain recent developments in the study of this disease. J. Pediat. 56: 109, 1960. CrossrefMedlineGoogle Scholar2. HOLLEY HL: Unpublished data. Google Scholar3. DUSTANTAYLORCORCORANPAGE HPRDACIH: Rheumatic and febrile syndrome during prolonged hydralazine treatment. J. A. M. A. 154: 23, 1954. CrossrefMedlineGoogle Scholar4. PERRYSCHROEDER HMHA: Syndrome simulating collagen disease caused by hydralazine (Apresoline). J. A. M. A. 154: 670, 1954. CrossrefMedlineGoogle Scholar5. SHACKMANSWILLERMORRISON NHAIM: Syndrome simulating acute disseminated lupus erythematosus-appearance after hydralazine (Apresoline) therapy. J. A. M. A. 155: 1492, 1954. CrossrefMedlineGoogle Scholar6. 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Author, Article, and Disclosure InformationAffiliations: Department of Medicine The University of Alabama Medical Center Medical College of Alabama Birmingham 3, Alabama PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByDrug-induced systemic lupus erythematosus: A critical reviewQuinidine-induced systemic lupus erythematosus.Connective Tissue Disease following Anti-epileptic TherapyVasculitis following procaine amide therapyAntinuclear Antibodies Following Hydralazine ToxicityProcainamide Induced Lupus Erythematosus SyndromePOSSIBLE INDUCTION OF ANTINUCLEAR ANTIBODIES BY ISONIAZIDBone Marrow Depression after Drug Therapy in Patients with Systemic Lupus ErythematosusLupus Diathesis and the Hydralazine SyndromeRheumatism and Arthritis Review of American and English Literature of Recent Years (Sixteenth Rheumatism Review)CHARLEY J. SMYTH, M.D., F.A.C.P., ROGER L. BLACK, M.D., CHARLES CHRISTIAN, M.D., MACK L. CLAYTON, M.D., F.A.C.S., DONALD F. HILL, M.D., F.A.C.P., JOSEPH LEE HOLLANDER, M.D., F.A.C.P., WILLIAM M. MIKKELSEN, M.D., F.A.C.P., MAX M. MONTGOMERY, M.D., F.A.C.P., CARL M. PEARSON, M.D., F.A.C.P., HUGH A. SMYTHE, M.D., F.R.C.P. (C), L. EMMERSON WARD, M.D., F.A.C.P., HOWARD J. WEINBERGER, M.D., F.A.C.P.Drugs and the ‘lupus diathesis’Current Concepts of the Pathogenesis of the So-Called Collagen DiseasesRheumatoid arthritis–An infection?Demonstration of anti-hydralazine antibody in hydralazine inducedLupus erythematosusProcainamide-Induced Lupus Erythematosus 1 December 1961Volume 55, Issue 6Page: 1036-1039KeywordsDrug therapyEtiologyHypersensitivityLupus erythematosusPlasma cellsPlasma proteins Issue Published: 1 December 1961 PDF DownloadLoading ...