Leukemoid Reaction, Hyperuricemia, and Severe Hyperpyrexia Complicating a Fatal Case of Acute Fatty Liver of the Alcoholic
Authors: ROBERT W. COLMAN
Journal: Annals of Internal Medicine (1962)

Case Studies1 July 1962Leukemoid Reaction, Hyperuricemia, and Severe Hyperpyrexia Complicating a Fatal Case of Acute Fatty Liver of the AlcoholicROBERT W. COLMAN, M.D., HARVEY M. SHEIN, M.D.ROBERT W. COLMAN, M.D.Search for more papers by this author, HARVEY M. SHEIN, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-57-1-110 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptAlcoholics dying in hepatic failure may be grouped into 3 distinct clinical categories, each correlated with a predominant change in liver histology: portal fibrosis, necrosis, or fatty infiltration (1). The fatal outcome in patients with fibrosis or necrosis may be presumed to be lack of sufficient functioning hepatic tissue. On the other hand, the cause of death is often obscure in those patients whose livers show only fatty infiltration, because it has been shown that fatty change per se does not interfere with most hepatic functions.A case is reported of acute hepatic failure in a young female alcoholic whose...References1. POPPERSZONTO HPB: Fatty liver with hepatic failure in alcoholics. J. Mount Sinai Hosp. 24: 1121, 1957. MedlineGoogle Scholar2. MATEERBALTZMARIONMACMILLAN JGJIDFJM: An improved bromosulfphalein test with a new normal standard. J. A. M. A. 121: 724, 1943. Google Scholar3. BESSEYLOWRYBROCK OAOHMJ: A method for the rapid determination of alkaline phosphatase with 5 cubic millimeters serum. J. Biol. Chem. 164: 321, 1946. CrossrefMedlineGoogle Scholar4. HANGER FM: Serological differentiation of obstruction from hepatogenous jaundice by flocculation of cephalin-cholesterol emulsions. J. Clin. Invest. 18: 261, 1939. CrossrefMedlineGoogle Scholar5. GORNALLBARDAWILLDAVID AACJMM:. Determination of serum proteins by means of the biuret reaction. J. Biol. Chem. 177: 751, 1949. CrossrefMedlineGoogle Scholar6. HOWE PE: The use of sodium sulfate as the globulin precipitant in the determination of proteins in blood. J. Biol. Chem. 49: 93, 1921. CrossrefGoogle Scholar7. DUCCIWATSON HCJ: The quantitative determination of the serum bilirubin with special reference to the prompt reacting and choloroform soluble types. J. Lab. Clin. Med. 30: 293, 1945. Google Scholar8. SCHOENHEIMERSPERRY RWM: A micromethod for the determination of free and combined cholesterol. J. Biol. Chem. 106: 745, 1934. CrossrefGoogle Scholar9. WINTROBELANDSBERG MMJW: A standardized technique for the blood sedimentation test. Amer. J. Med. Sci. 189: 102, 1935. CrossrefGoogle Scholar10. HARRISON GA: Chemical Methods in Clinical Medicine, J. and A. Churchill, London, 1937. Google Scholar11. SOMOGYI M: Micromethods for the estimation of diastase. J. Biol. Chem. 125: 399, 1938. CrossrefGoogle Scholar12. LEYLEWISDAVIDSON ABJHCS: The quantative determination of the thymol turbidity reaction of serum. J. Lab. Clin. Med. 31: 910, 1946. MedlineGoogle Scholar13. WROBLEWSKILADUE FJS: Serum glutamic oxalacetic transaminase activity as an index of liver cell injury: a preliminary report. Ann. Intern. Med. 43: 345, 1955. LinkGoogle Scholar14. QUICK AJ: Physiology and Pathology of Hemostasis, Lea and Febiger, Philadelphia, 1951, pp. 125-134. Google Scholar15. WINTROBE MM: The erythrocyte in man. Medicine 9:195, 1930. CrossrefGoogle Scholar16. ADAMSFOLEY RDJM: The neurological disorder associated with liver disease. Res. Publ. Ass. Res. Nerv. Ment. Dis. 32: 198, 1953. MedlineGoogle Scholar17. SOBEL H: A modified carbonate-phosphotungstate method for the determination of uric acid and comparison with the spectrophotometric uricase method. Amer. J. Clin. Path. 28: 152, 1957. CrossrefMedlineGoogle Scholar18. MALLORY FB: Cirrhosis of the liver. New Engl. J. Med. 206: 1231, 1932. CrossrefGoogle Scholar19. POPPERSZONTOPARATHASARTHY HPBM: Florid cirrhosis. Amer. J. Clin. Path. 25: 889, 1955. CrossrefMedlineGoogle Scholar20. PHILLIPSDAVIDSON GBCS: Liver disease of the chronic alcoholic simulating extrahepatic biliary obstruction. Gastroenterology 33: 240, 1957. CrossrefGoogle Scholar21. WINTROBE MM: Clinical Hematology, 4th Ed., Lea and Febiger, Philadelphia, 1956, pp. 248-250. Google Scholar22. FELDMANSTASNEY WHJ: Leukemoid response of tuberculous rabbits to administration of tuberculin. Amer. J. Med. Sci. 193: 28, 1937. CrossrefGoogle Scholar23. HUGHESJOHNSTONESCOTTSTEWART JTRMACPD: Leukemoid reactions in disseminated tuberculosis. J. Clin. Path. 12: 307, 1959. CrossrefMedlineGoogle Scholar24. POPPERSCHAFFNER HF: Liver: Structure and Function, McGraw-Hill Book Company, Inc., New York, 1957, p. 254. Google Scholar25. WAY GT: Fatal eclampsia: A clinical and anatomic correlative study. Amer. J. Obst. Gyn. 54: 928, 1947. CrossrefMedlineGoogle Scholar26. PHILLIPSDAVIDSON GBCS: Acute hepatic insufficiency of the chronic alcoholic: clinical and pathological study. Arch. Intern. Med. 94: 585, 1954. CrossrefGoogle Scholar27. STORMONTMACKIEKASSDAVIDSON JMJEEHCS: Bacteriologic culture of the diseased human liver. Ann. Intern. Med. 51: 17, 1959. LinkGoogle Scholar28. BOCKUS HL: Gastroenterology, Vol. 3, W. B. Saunders Company, Philadelphia, 1946, p. 36. Google Scholar29. WOOD WB: Studies on the cause of fever. New Engl. J. Med. 258: 1023, 1958. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Boston, MassachusettsFrom the Thorndike Memorial Laboratory and the Second and Fourth (Harvard) Medical Services, Boston City Hospital, and the Department of Medicine, Harvard Medical School, Boston, Massachusetts.Requests for reprints should be addressed to the Director, Second and Fourth (Harvard) Medical Services, Boston City Hospital, Boston, Massachusetts. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByAlcoholic Liver DiseaseLeukemoid Reaction Associated with Parenteral NutritionSteatosis, cholestasis, and alkaline phosphatase in alcoholic liver diseaseCase 42-1972Intrahepatic Cholestasis vs. Posthepatic Jaundice: Methods of Diagnosis: With a Note on Hypercholesteremic Xanthomatosis in a Patient with Chlorpromazine CholestasisSclerosing Hyaline Necrosis of the Liver in the Chronic Alcoholic A Recognizable Clinical SyndromeHUGH A. EDMONDSON, M.D., F.A.C.P., ROBERT L. PETERS, M.D., TELFER B. REYNOLDS, M.D., F.A.C.P., OLIVER T. KUZMA, M.D. 1 July 1962Volume 57, Issue 1Page: 110-115KeywordsAcute liver failureAlcoholicsFatty liverHospital medicineLiver fibrosisMedical servicesNecrosisPhosphatasesProteinsResearch laboratories Issue Published: 1 July 1962 PDF DownloadLoading ...