tbuckley/cabot-search huggingface dataset:
Merkel cell carcinoma in a human immunodeficiency virus-infected patient
Authors: L. Calza, C. Beltrami, R. Manfredi, V. Colangeli, E. Freo, F. Chiodo
Journal: British Journal of Dermatology (2002)

Journal Article Merkel cell carcinoma in a human immunodeficiency virus‐infected patient Get access L. Calza, L. Calza Department of Clinical and Experimental Medicine, Division of Infectious Diseases, University of Bologna, S. Orsola Hospital, via Massarenti 11, 40138 Bologna, Italy Dr Leonardo Calza. E‐mail: malinf@med.unibo.it Search for other works by this author on: Oxford Academic Google Scholar C. Beltrami, C. Beltrami Department of Clinical and Experimental Medicine, Division of Infectious Diseases, University of Bologna, S. Orsola Hospital, via Massarenti 11, 40138 Bologna, Italy Search for other works by this author on: Oxford Academic Google Scholar R. Manfredi, R. Manfredi Department of Clinical and Experimental Medicine, Division of Infectious Diseases, University of Bologna, S. Orsola Hospital, via Massarenti 11, 40138 Bologna, Italy Search for other works by this author on: Oxford Academic Google Scholar V. Colangeli, V. Colangeli Department of Clinical and Experimental Medicine, Division of Infectious Diseases, University of Bologna, S. Orsola Hospital, via Massarenti 11, 40138 Bologna, Italy Search for other works by this author on: Oxford Academic Google Scholar E. Freo, E. Freo Department of Clinical and Experimental Medicine, Division of Infectious Diseases, University of Bologna, S. Orsola Hospital, via Massarenti 11, 40138 Bologna, Italy Search for other works by this author on: Oxford Academic Google Scholar F. Chiodo F. Chiodo Department of Clinical and Experimental Medicine, Division of Infectious Diseases, University of Bologna, S. Orsola Hospital, via Massarenti 11, 40138 Bologna, Italy Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 146, Issue 5, 1 May 2002, Pages 895–898, https://doi.org/10.1046/j.1365-2133.2002.04646.x Published: 01 May 2002 Article history Accepted: 18 October 2001 Published: 01 May 2002
Acute Emotional Stress and the Heart
Authors: Janet M. Torpy, Alison E. Burke, Richard M. Glass
Journal: JAMA (2003)

Acute Emotional Stress and the Heart Experiencing emotional or physical stress causes an increase in heart rate, elevation of blood pressure, and release of stress hormones.All these result in a greater workload for the heart, which can be dangerous.Stress can cause a heart attack, sudden cardiac death, heart failure, or arrhythmias (abnormal heart rhythms) in persons who may not even know they have heart disease.Individuals with congestive heart failure, coronary heart disease, known arrhythmias, or other heart or blood vessel diseases should avoid emotional stress whenever possible and learn to manage the effects of stress.Excessive physical exertion and emotional stress may cause problems in both men and women, but women seem to be particularly susceptible to developing heart problems in the face of emotional stress.Ask your doctor about any limitations on physical activity or vigorous exercise if you have heart disease.The July 18, 2007, issue of JAMA includes an article about acute emotional stress and its effects on the heart.
Die Gefäßendoskopie: Ein neuer Weg der intraoperativen Gefäßdiagnostik
Authors: J. Vollmar
Journal: Endoscopy (1969)

The endoscopy of blood vessels represents an important intra-operative diagnostic procedure in vascular surgery. This is especially true in controlling semiclosed desobliteration of the aorto-iliac andfemoro-popliteal segment, furthermore, in examining the complete removal of thrombi in acute phlebothrombosis. Technically a working instrumentarium, a passable vessel calibre and a translucent milieu are necessary (temporary clamping of the bloodstream by clamps or balloon catheter, continuous perfusion through the endoscope). The advantage of an examination on an open vessel by a relatively simple method compared with the conventional intra-operative procedures is quite obvious. The endoscopy of major veins will bring new thought about the mechanism of venous valves and will lead to a fast and certain diagnosis of the so-called pelvic vein calcar.
Patients' understanding of anticoagulant therapy in a multiethnic population
Authors: S. Nadar, N. Begum, B. Kaur, S. Sandhu, G. Y H Lip
Journal: Journal of the Royal Society of Medicine (2003)

To investigate whether knowledge and perceptions of antithrombotic therapy differ between ethnic groups in the UK, we conducted a cross-sectional questionnaire survey of patients attending anticoagulation clinics in three Birmingham teaching hospitals.180 consecutive patients were recruited-135 white European, 29 Indo-Asian, 16 Afro-Caribbean.The average knowledge score was 5.5 out of 9, with no significant differences between the groups.Indo-Asians were significantly less likely than the other groups to know the name of the anticoagulant they were taking (warfarin) and Afro-Caribbeans to know the condition for which they were being anticoagulated.Few patients of any group were able to specify more than one side-effect of warfarin or the dose they were on.In logistic regression analysis the factors associated with a low score were age 461 years, having been born outside the UK, and the perception of difficulty in comprehension.Nearly half the Indo-Asians felt unable to understand what was said to them in the clinic, and 62% expressed a preference for a doctor of the same ethnic group.Although there were no significant between-group differences, this study points to gaps in the knowledge of patients from ethnic minorities and to deficiencies in the provision of information.In patient education, these groups should receive special attention.
Fixed-Dose Unfractionated Heparin vs Low-Molecular-Weight Heparin for Venous Thromboembolism
Authors: Jonathan Lee Edwards
Journal: JAMA (2007)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
On the Advantages to be Derived from Curving the Handles of Midwifery Forceps
Authors: J. H. Aveling
Journal: BMJ (1870)

owing to the latitude, which is five degrees more south than Marseilles, to the proximity of the sea, and to the shelter of the Sahel hills, which rise behind the town.Even at Algiers, however, sharp frosts occasionally occur.Thus Colonel Playfair,
Differentialdiagnose innerer Krankheiten: Eine kurzgefasste Darstellung für Ärzte und Studierende
Authors: F. D. Zeman
Journal: JAMA (1961)

The sixth edition of this excellent textbook was reviewed in these columns in August, 1959 (<i>J. A. M. A.</i><b>170</b>:2261-2262, 1959). Now in hand is the seventh edition, enlarged, revised, and enriched by about 40 additional illustrations. In the interim, the third edition in Italian has appeared, and translations into Greek and Polish are in preparation. Considering that the first edition in German made its bow in 1952, one can hardly fail to be impressed by the wide acceptance of the book, as well as by the efforts of both editor and publisher to keep abreast of the rapidly changing body of knowledge in the field. The author's approach is best expressed in the foreword, where he states that he has endeavored to embody all the scientific advances in experimental medicine and the laboratory sciences, at the same time stressing bedside observation, study of the course of the disease,
Let doctors help terminally ill patients to die, says commission
Authors: C. Dyer
Journal: BMJ (2012)

Doctors in England and Wales could be allowed to assist terminally ill people to end their lives under strict safeguards without endangering the vulnerable, the most comprehensive UK inquiry into assisted dying has concluded.

The independent Commission on Assisted Dying, chaired by former Labour lord chancellor Charles Falconer, says doctors could safely be allowed to provide medication to those with a terminal illness and a prognosis of no more than 12 months’ survival who want to decide for themselves when to die.

To be eligible, they would have to be at least 18 years of age and have the mental capacity to take the decision. Those who might be clinically depressed or experiencing pressure from friends or relatives would be protected by a comprehensive set of safeguards.

The high level commission was hosted by the think tank Demos and funded by the businessman Bernard Lewis and the best selling author …
What Is the Optimal Therapy for Patients with H5N1 Influenza?
Authors: Nicholas J. White, Robert G. Webster, Elena A. Govorkova, Timothy M. Uyeki
Journal: PLoS Medicine (2009)

Background to the debate In a 2007 article in PLoS Medicine [10], Holger J. Schünemann and colleagues described a new process used by the World Health Organization for rapidly developing clinical management guidelines in emergency situations. These situations include outbreaks of emerging infectious diseases. The authors discussed how they developed such a "rapid advice" guideline for the pharmacological management of avian influenza A (H5N1) virus infection. The guideline recommends giving the antiviral drug oseltamivir at a dose of 75 mg twice daily for five days. In this Debate, Nicholas White argues that such dosing is inadequate, Robert Webster and Elena Govorkova say that combination antiviral therapy should be used, and Tim Uyeki reminds us that clinical care of patients with H5N1 entails much more than antiviral treatment. These issues may also apply to therapy of patients hospitalized with severe disease due to novel swine-origin influenza A (H1N1) virus infection.
Pain management in children and adolescents with sickle cell disease
Authors: Jeanette M. Jerrell, Avnish Tripathi, James R. Stallworth
Journal: American Journal of Hematology (2010)

In a cohort of 2,194 children with sickle cell disease (SCD) treated in community-based services, we explored the types of medications used to treat vaso-occlusive (VOC) pain episodes, and the relative effectiveness of nonsteroidal anti-inflammatory drugs (NSAIDs), opioids, and adjunctive antidepressants or anticonvulsant medications on reducing acute VOC pain visits over time. Pharmacologic treatments for VOC pain consisted mainly of NSAIDs and weak opioids. Significantly more patients with more than 3 inpatient or ER VOC pain visits during their first year of SCD treatment were prescribed stronger opioids, SSRIs, SNRI/heterocyclics, and anticonvulsants. Prescription of both stronger opioids and SSRI antidepressants or anticonvulsants was significantly associated with lower cumulative rates of acute VOC pain visits over time. Using an observational study design and existing clinical data, these findings are intended to illustrate the potential clinical advantages of combining adjunctive antidepressants or anticonvulsants with primary pain medications for relief of acute VOC pain over time.
Autonomic neuropathy after cisplatin based chemotherapy.
Authors: P Richardson, B M Cantwell
Journal: BMJ (1990)

hypertension may be compared.It is still common to use a too high a dose, making the new treatment look superior.We agree that some new drugs do not have any adverse metabolic effects, even in high doses.It should be remembered, however, that there are no clinical data showing that such new drugs reduce the mortality and morbidity of hypertension.Thiazides in doses that we consider high affect the risk of stroke in hypertensive patients-we now need to know whether lower doses of thiazides also prevent mvocardial infarction and decrease related mortality.
TCTAP A-093 Determinants of Self-Discontinuation of Secondary Prevention Medications by Coronary Heart Disease Outpatients: Focus on the Role of Erectile Dysfunction
Authors: Ali Yousif Nori, Bahar Ibrahim, Muhamad Ali S.K. Abdul Kader, Mohamed Azmi Hassali, Rahmat Awang
Journal: Journal of the American College of Cardiology (2015)
Psoriasis and Risk of Myocardial Infarction—Reply
Authors: Joel M. Gelfand, Shanu Kohli Kurd, Andrea L. Neimann, Daniel B. Shin, David J. Margolis, Andrea B. Troxel
Journal: JAMA (2007)

In Reply: Dr Alevizos and colleagues suggest that the association of psoriasis and MI that we observed may be due to psoriasis-associated depression. Although this possibility requires further research to fully address, confounding by depression is unlikely to explain our results.
Chromosome-wide distribution of haplotype blocks and the role of recombination hot spots
Authors: M.S. Phillips, R. Lawrence, R. Sachidanandam, A.P. Morris, D.J. Balding, M.A. Donaldson, J.F. Studebaker, W.M. Ankener, S.V. Alfisi, F.-S. Kuo, A.L. Camisa, V. Pazorov, K.E. Scott, B.J. Carey, J. Faith, G. Katari, H.A. Bhatti, J.M. Cyr, V. Derohannessian, C. Elosua, A.M. Forman, N.M. Grecco, C.R. Hock, J.M. Kuebler, J.A. Lathrop, M.A. Mockler, E.P. Nachtman, S.L. Restine, S.A. Varde, M.J. Hozza, C.A. Gelfand, J. Broxholme, G.R. Abecasis, M.T. Boyce-Jacino, L.R. Cardon
Journal: Nature Genetics (2003)
Child Abuse as a Cause of Post-Traumatic Hypopituitarism
Authors: Walter L. Miller, Selna L. Kaplan, Melvin M. Grumbach
Journal: New England Journal of Medicine (1980)

Irreversible disturbances of hypothalamic-pituitary function are rarely reported as a complication of closed head injury and, to our knowledge, have not been reported in physically abused children. Whereas diabetes insipidus is a well-described complication of closed head injury in children and adults,1 , 2 post-traumatic anterior hypopituitarism is a rarely reported disorder that may result from injury to the anterior pituitary,3 , 4 the pituitary stalk,5 , 6 or the hypothalamus.7 This report describes three children in whom battery in infancy resulted in subdural hematomas, brain injury, anterior hypopituitarism, and impaired growth. In at least two of the patients, the hypopituitarism was secondary to deficiencies of . . .
Endothelial targeting of a recombinant construct fusing a PECAM-1 single-chain variable antibody fragment (scFv) with prourokinase facilitates prophylactic thrombolysis in the pulmonary vasculature
Authors: Bi-Sen Ding, Claudia Gottstein, Andrea Grunow, Alice Kuo, Kumkum Ganguly, Steven M. Albelda, Douglas B. Cines, Vladimir R. Muzykantov
Journal: Blood (2005)
Stranger's Heart
Authors: Phillip J. Cozzi
Journal: Annals of Internal Medicine (2001)

Ad Libitum20 March 2001Stranger's HeartPhillip J. Cozzi, MDPhillip J. Cozzi, MDElmhurst, IL 60126 (Cozzi)Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-134-6-200103200-00022 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail Garish ... Author, Article, and Disclosure InformationAffiliations: Elmhurst, IL 60126 (Cozzi)Corresponding Author: Phillip J. Cozzi, MD, 447 Cottage Hill, Elmhurst, IL 60126. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 20 March 2001Volume 134, Issue 6Page: 530KeywordsHeartInterleukinsLungsRibsThorax ePublished: 20 March 2001 Issue Published: 20 March 2001 Copyright & PermissionsCopyright © 2001 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
African sleeping sickness
Authors: Francesco Checchi, Michael P Barrett
Journal: BMJ (2008)

Eflornithine should be the drug of choice for stage 2 disease, but resistance must be monitored When human African trypanosomiasis (sleeping sickness) killed millions of people during Africa's colonial period 60100 years ago, interest was similar to that for today's HIV epidemic, but the disease is now largely forgotten.The continuing importance of this disease is highlighted in the accompanying paper by Priotto and colleagues, who report the effectiveness and safety of eflornithine used for its first line treatment.1
Early changes in excitation-contraction coupling: transition from compensated hypertrophy to failure in Dahl salt-sensitive rat myocytes
Authors: Kohzo Nagata, Ronglih Liao, Franz R Eberli, Naoya Satoh, Brigitte Chevalier, Carl S Apstein, Thomas M Suter
Journal: Cardiovascular Research (1998)

Objective: The aims were to (1) define the early changes in excitation-contraction coupling during the transition from cardiac hypertrophy to heart failure, and (2) to clarify the causal relationship between mechanical dysfunction and abnormal Ca2+ handling in the Dahl salt-sensitive rat model. Methods: Myocardial contractile function was assessed in whole heart perfusion studies. In separate experiments, isolated left ventricular myocytes from Dahl salt-sensitive (DS) and Dahl salt-resistant (DR) rats were paced at a physiological rate of 5Hz and cell shortening (CS) and [Ca2+]i measured simultaneously by video-edge detection and fura-2 fluorescence. Results: DS hearts developed hypertrophy after 4 weeks of a high-salt diet (4WHSD), as indicated by a 26% increase (p<0.01) in the heart to body weight ratio and a 21% increase (p<0.01) in cell width. Heart failure developed after 12 weeks of a high-salt diet (12WHSD), as indicated by an 11% increase (p<0.01) in the lung wet to dry weight ratio. Furthermore, in DS-12WHSD hearts, the diastolic pressure-volume relationship had shifted rightward. DR rats did not develop hypertension and served as age-matched controls. A 31% (p<0.05) increase in the %CS in DS-4WHSD myocytes compared to DR-4WHSD myocytes with a trend of a parallel increase in Ca2+ transient amplitude was found. There was no difference in the Ca2+ transient parameters between DR and DS at 12WHSD, but an 18% (p<0.01) decrease occurred in peak [Ca2+]i in DS myocytes between 4WHSD and 12WHSD. In DS-12WHSD, the time to peak shortening and the time from peak shortening to 50% and 90% relaxation was significantly prolonged by 27%, 44%, and 38%, respectively, as compared to the age-matched DR myocytes. Conclusion: Our results indicated that: (1) normal Ca2+ homeostasis is preserved at the stage of compensated hypertrophy; (2) the early signs of isolated myocyte dysfunction were a prolongation of the shortening and relaxation time course without an abnormal time course of the Ca2+ transient. Thus, in the hypertensive Dahl salt rat model, abnormal Ca2+ handling appears neither to precede nor initiate the transition to failure.
In vivo expression and function of hybrid Ia dimers (E alpha A beta) in recombinant and transgenic mice.
Authors: G D Anderson, C S David
Journal: The Journal of Experimental Medicine (1989)

We have found cell surface expression of an E alpha molecule in recombinant and transgenic mouse strains lacking an E beta molecule. Flow cytometry has shown low level expression of E alpha in B10.RQB3 (I-AqEk alpha) and B10.RFB2 (I-AfEk alpha) mice. We have also found that B10.Q (H-2q) mice can express the Ek alpha transgene. Since these strains do not have functional E beta chains, we propose that the E alpha A beta hybrid dimers are formed in low numbers and can be picked up by FACS analysis. So far we have not been able to identify these hybrid molecules by cytotoxicity or immunoprecipitation. The E alpha/A beta molecule can function in vivo during thymic selection in the clonal deletion of two V beta TCR subsets, V beta 11 and V beta 6, which have been shown to interact with the intact I-E molecule.
Intraperitoneal Lymphokine-Activated Killer Cell/Interleukin-2 Therapy in Patients With Intra- abdominal Cancer: Immunologic Considerations
Authors: Walter J. Urba, Jeffrey W. Clark, Ronald G. Steis, Michael A. Bookman, John W. Smith, Suzanne Beckner, Annette E. Maluish, Jeffrey L. Rossio, Helen Rager, John R. Ortaldo, Dan L. Longo
Journal: JNCI Journal of the National Cancer Institute (1989)

Journal Article Intraperitoneal Lymphokine-Activated Killer Cell/Interleukin-2 Therapy in Patients With Intra- abdominal Cancer: Immunologic Considerations Get access Walter J. Urba, Walter J. Urba Search for other works by this author on: Oxford Academic PubMed Google Scholar Jeffrey W. Clark, Jeffrey W. Clark Search for other works by this author on: Oxford Academic PubMed Google Scholar Ronald G. Steis, Ronald G. Steis Search for other works by this author on: Oxford Academic PubMed Google Scholar Michael A. Bookman, Michael A. Bookman Search for other works by this author on: Oxford Academic PubMed Google Scholar John W. Smith, John W. Smith Search for other works by this author on: Oxford Academic PubMed Google Scholar Suzanne Beckner, Suzanne Beckner Search for other works by this author on: Oxford Academic PubMed Google Scholar Annette E. Maluish, Annette E. Maluish Search for other works by this author on: Oxford Academic PubMed Google Scholar Jeffrey L. Rossio, Jeffrey L. Rossio Search for other works by this author on: Oxford Academic PubMed Google Scholar Helen Rager, Helen Rager Search for other works by this author on: Oxford Academic PubMed Google Scholar John R. Ortaldo, John R. Ortaldo Search for other works by this author on: Oxford Academic PubMed Google Scholar ... Show more Dan L. Longo Dan L. Longo Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 81, Issue 8, 19 April 1989, Pages 602–611, https://doi.org/10.1093/jnci/81.8.602 Published: 19 April 1989 Article history Received: 01 December 1988 Revision received: 23 January 1989 Accepted: 25 January 1989 Published: 19 April 1989