VARYING RESPONSES TO RADIOACTIVE IODINE (I^131) THERAPY IN HYPERTHYROID PATIENTS
Authors: Melvin D. Cheitlin, Robert Bernstein, Edward A. Langdon
Journal: Annals of Internal Medicine (1960)

Article1 February 1960VARYING RESPONSES TO RADIOACTIVE IODINE (I131) THERAPY IN HYPERTHYROID PATIENTSMELVIN D. CHEITLIN, ROBERT BERNSTEIN, EDWARD A. LANGDONMELVIN D. CHEITLINSearch for more papers by this author, ROBERT BERNSTEINSearch for more papers by this author, EDWARD A. LANGDONSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-52-2-349 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptIn the last decade the use of radioactive iodine (I131) has come to occupy a place beside subtotal thyroidectomy as a definitive treatment for hyperthyroidism. The excellent results—comparable in every way to those obtained with surgery—coupled with the ease of administration, make this form of therapy most attractive. Furthermore, the absence of the surgical complications of recurrent laryngeal nerve injury and parathyroid ablation, infrequent as they are, gives radioactive iodine a distinct advantage over operation. The one great obstacle to the more general use of this substance, especially in the age group under 40, has been concern regarding the possibility...Bibliography1. BeierwaltesJohnson WHPC: Hyperthyroidism treated with radioiodine: a seven year experience, Arch. Int. Med. 97: 393, 1956. CrossrefGoogle Scholar2. Freedberg AS: Iodine 131 in the treatment of hypothyroidism: studies of dosage and metabolism, in Radioisotopes in medicine, Washington, D. C., U. S. Atomic Energy Commission, 1955, pp. 298-309. Google Scholar3. HamwiGoldberg GJRF: The modern treatment of thyrotoxicosis, Arch. Int. Med. 97: 453, 1956. CrossrefGoogle Scholar4. ClarkRule DEJH: Radioactive iodine or surgery in the treatment of hyperthyroidism, J. A. M. A. 159: 995, 1955. CrossrefMedlineGoogle Scholar5. BlomfieldEckertFisherMillerMunroWilson GWHMHDSGM: Treatment of thyrotoxicosis with I131: a review of 500 cases, Brit. M. J. 1: 63, 1959. CrossrefMedlineGoogle Scholar6. Myant NB: Prognostic value of early tests of thyroid function after treatment of thyrotoxicosis by (I131), Brit. J. Radiol. 26: 139, 1953. CrossrefMedlineGoogle Scholar7. SchultzZieve AL: Early prediction of success or failure of radioiodine therapy of hyperthyroidism, J. Clin. Endocrinol. 15: 834, 1955 (abstract). Google Scholar8. Allen HC: Subtotal ablation of the thyroid gland with a single dose of radioactive iodine I131 for the treatment of thyrotoxicosis, South. M. J. 49: 1428, 1956. CrossrefMedlineGoogle Scholar9. BeckHobbs REAA: Observations in the treatment of hyperthyroidism with I131 , Ann. Int. Med. 47: 241, 1957. LinkGoogle Scholar10. MarinelliQuimbyHine LDEHGJ (a) : Dosage determination with radioactive isotopes. I. Fundamental dosage formulae, Nucleonics 2: 56, 1948. (b) Marinelli, L. D., Quimby, E. H., and Hine, G. J.: Dosage determination with radioactive isotopes. II. Biological considerations and practical applications, Nucleonics 2: 44, 1948. MedlineGoogle Scholar11. Chapman EM: Iodine131 in the treatment of hyperthyroidism: interpretation of a long range program, in Radioisotopes in medicine, Washington, D. C., U. S. Atomic Energy Commission, pp. 310-320, 1955. Google Scholar12. Kelley FJ: Observations on the calculation of thyroid weight, using empirical formulae, J. Clin. Endocrinol. 14: 326, 1954. CrossrefGoogle Scholar13. ChapmanMaloof EMF: Used radioactive iodine in the diagnosis and treatment of hyperthyroidism: ten years' experience, Medicine 34: 261, 1955. CrossrefMedlineGoogle Scholar14. MagalottiHummonHierschbiel MFIFE: The effect of disease and drugs on the twenty-four hour I131 thyroid uptake, Am. J. Roentgenol. 81: 47, 1959. Google Scholar15. KeatingPowerBerksonHaines FRMHJSF: The urinary excretion of radioiodine in various thyroid states, J. Clin. Investigation 26: 1138, 1947. CrossrefGoogle Scholar16. Van Middlesworth L: A method for iodide balance studies in animals on low iodide diets, J. Clin. Endocrinol. 15: 835, 1955. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: *Received for publication August 6, 1959.From the Radioisotope Clinic, Walter Reed Army Hospital and Walter Reed Army Institute of Research, WRAMC, Washington, D. C.Requests for reprints should be addressed to Captain Melvin D. Cheitlin (MC), Walter Reed Army Hospital, Washington 12, D. C. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byRadioiodine treatment in pediatric Graves disease and thyroid carcinoma 1 February 1960Volume 52, Issue 2Page: 349-361KeywordsAge groupsHospitalsHyperthyroidismNervesParathyroidProteinsSedationThyroidThyroidectomy ePublished: 1 December 2008 Issue Published: 1 February 1960 PDF downloadLoading ...