tbuckley/cabot-search huggingface dataset:
Effects of lithium carbonate on memory and other cognitive functions
Authors: L R Squire, L L Judd, D S Janowsky, L Y Huey
Journal: American Journal of Psychiatry (1980)

The authors studied the effects of lithium carbonate on memory and cognitive function in 16 psychiatric patients, who received lithium for 2 weeks and placebo for 2 weeks in a double-blind cross-over design. At the end of each treatment phase, subjects were administered a battery of memory and cognitive tests. As reported previously, lithium induced slowing of performance on certain of the perceptual motor tests; however, lithium did not cause memory impairment or a change in self-assessment of memory functions.
Anesthesia for complex endoscopy: a made-to-measure suit
Authors: Fabio Sbaraglia, Guido Costamagna, Maria Sammartino
Journal: Endoscopy (2015)

We were particularly interested by the editorial on new frontiers of anesthesia in endoscopy, recently published in Endoscopy [1]. This editorial, commenting on a report by Lara et al. [2] on adverse events of anesthesiological procedures in the endoscopy setting, takes the opportunity to state “a new paradigm” and to highlight some key messages.
Abstract 11855: High Doses of Vegf165 as Sole Gene Therapy for Patients with Inoperable Coronary Artery Disease and Refractory Angina: 1-Year Follow-Up From a Phase I/ii Clinical Trial
Authors: Clarissa B Rodrigues, Roberto T Sant'Anna, Bruna Eibel, Felipe A Salles, Nance B Nardi, Sang W Han, Eduardo Ludwig, Gabriel Grossman, Mauricio B Marques, Melissa M Markoski, Joao Ricardo M Sant'Anna, Paulo R Prates, Ivo A Nesralla, Renato Kalil
Journal: Circulation (2011)

Background: Gene therapy using specific cytokines has potential to induce angiogenesis and improve collateral circulation in ischemic tissue. There is debate of what are the most appropriate gene, ...
Snail1-induced partial epithelial-to-mesenchymal transition drives renal fibrosis in mice and can be targeted to reverse established disease
Authors: M Teresa Grande, Berta Sánchez-Laorden, Cristina López-Blau, Cristina A De Frutos, Agnès Boutet, Miguel Arévalo, R Grant Rowe, Stephen J Weiss, José M López-Novoa, M Angela Nieto
Journal: Nature Medicine (2015)
Abstract 19378: First Experience with Concomitant AT1 and Neprilysin (NEP 24.11) Inhibition with LCZ696 in Patients with Chronic Heart Failure
Authors: Zhanna Kobalava, Elena Pavlikova, Oleg Averkov, Valentin Moiseev, Diego Albrecht, Aimen Feng, Priyamvada Chandra, Pierre J Jordaan
Journal: Circulation (2010)

Introduction: In the setting of heart failure (HF), chronic RAAS activation is detrimental, while NEP (neprilysin, NEP 24.11) activation is expected to induce a beneficial response. LCZ696, an angiotensin receptor neprilysin inhibitor (ARNI), offers the synergy of concomitant angiotensin II AT1 receptor and neprilysin enzyme inhibition. We report the first results of LCZ696 in patients with stable chronic HF, exploring the tolerability of LCZ696. Methods: Patients with stable HF (NYHA II-IV, LVEF <40), on optimal medical therapy entered an open-label study. After a short washout of ACEI therapy, patients were treated with LCZ696 100 mg BID for 7 days and then uptitrated to 200 mg BID for an additional 14 days, maintaining other chronic stable background therapy. Patients remained in the clinic during the study period. Results: Thirty patients (NYHA II 56%, LVEF 33.6±4.6%, male 83.3%, BMI 30.7±4.6kg/m2) entered the study. Background treatment included θ-blockers (90%), ASA (90%), statin (50%), aldosterone ...
Abstract 8577: Multidisciplinary Care of Patients Receiving Cardiac Resynchronization Therapy Improves Clinical Outcomes
Authors: Robert K Altman, Mary Orencole, Kimberly A Parks, Stephanie A Moore, Mi Young Park, Prabhat Kumar, Peerawut Deeprasertkul, Quynh A Truong, Christopher L Schlett, Gregory D Lewis, E. Kevin Heist, Michael H Picard, Jagmeet P Singh
Journal: Circulation (2011)

Background: Although cardiac resynchronization therapy (CRT) reduces morbidity and mortality in patients with heart failure, a substantial minority of patients do not respond adequately to this therapy. The objective of this study was to examine the impact of a ‘multidisciplinary care approach’ on clinical outcome. Methods: The clinical outcome in patients prospectively receiving multidisciplinary care (MC, n=254) was compared with a control group of patients who received conventional care (CC, n=173). The MC group was followed prospectively in an integrated clinic setting by a team of subspecialists from the heart failure, electrophysiology and echocardiography service at 1, 3 and 6 months post-implant. All patients had echocardiographic-guided optimization at their 1-month visit. Proportional hazard models (adjusting for all potential confounders) and Kaplan-Meier estimates for time to first event curves were compared between the 2 groups, over a 2-year follow up. Outcome was measured as a combined endpoint of heart failure hospitalization, cardiac transplantation or all-cause mortality. Results: The clinical characteristics between the MC and CC groups at baseline were comparable (age, 68+13 vs. 69+12; NYHA III, 90% vs. 82%; ischemic cardiomyopathy 55% vs. 64%, p=NS, respectively). The event free survival was significantly higher in the multidisciplinary vs. conventional care group (Figure, p=0.0015). A significant reduction in clinical events was noted in the MC versus the CC group ( 0.62, 95%CI 0.47-0.84, p = 0.002) and remained significant after adjustment (HR 0.67, p=0.03). Conclusion: Integrated multidisciplinary care improves 2-year event free survival in patients receiving cardiac resynchronization therapy.
INFECTIOUS DISEASE: Digging into Seaside Microbial Exposures
Authors: Angela Spivey
Journal: Environmental Health Perspectives (2009)

In the United States, only coal-and oil-fired power plants must report.**Each country's PRTR differs in the types of activities required to report under this sector.Water supply, sewage treatment** (200) 6 % Transportation equipment mfg.(285) 3 % Oil and gas extraction (production)*** (137) 15 % Chemicals mfg.(451) 3 % Paper products mfg.(115) 2 % Primary metals mfg.(246) 6 % Petroleum products mfg.(40) 3 % Services/support activities: mining, quarrying, oil/gas extraction*** (50) 58 % Fabricated metals mfg.(282) 2 % Waste management and remediation services* (127) 2 % Electrical equipment mfg.(76) 10 % Plastics and rubber mfg.(57) 5 % Generation and distribution of electricity* (49) 10 % Mining and quarrying (except oil and gas)** (33) 69 % Transportation equipment mfg.(206) 3 % Chemicals mfg.(324) 3 % *Only hazardous waste/solvent recovery facilities must report.**Only coal-and oil-fired power plants must report.***Each country's PRTR differs
Coronary vasodilation by noninvasive transcutaneous ultrasound
Authors: Takashi Miyamoto, Yoram Neuman, Huai Luo, Doo-Soo Jeon, Sergio Kobal, Fumiaki Ikeno, Michael Horzewski, Yasuhiro Honda, James M Mirocha, Takahiro Iwami, Debra Echt, Michael C Fishbein, Robert J Siegel
Journal: Journal of the American College of Cardiology (2003)
Spirituality correlates positively with higher quality of life and negatively with depression in a sample of low income brazilian cancer patients
Authors: A. Del Giglio, E. Ramos, C. G. Bensi, G. Centofanti, S. Frankfurt, A. Garcia, N. G. Tannuous
Journal: Journal of Clinical Oncology (2006)

18534 Background: Brazil has a multicultural mostly poor population with many different kinds of religious affiliations. Since cultural, psychological, spiritual and social factors may influence the quality of life (QOL) of cancer patients, we wanted to evaluate spirituality and its relation to depression and the QOL in a sanple of these patients. Methods: We surveyed 72 adult cancer patients through three questionnaires: a general one, the FACIT-Sp QOL questionnaire, as well as the Beck depression inventory, all of them already validated in Portuguese. From the FACIT-Sp questionnaire we obtained also the general quality of life (FACT-G) score. We evaluated correlations between variables with Chisquare, Fisher and ANOVA tests. Since multiple univariate correlations were assessed in this study, we considered significant only p values equal or bellow 0.005. We employed multiple regression analysis to evaluate if depression and spirituality would independently correlate with QOL. Results: We included 72 patients. The mean age was 52 years, 63.9% were female, 58.3% were married, 20.8% were regularly employed, and 59.7% had studied up to elementary school only. For most patients (66, 2%) their religious faith was the most important factor that helped them to cope with their disease. We found no statistical correlations between the scores of the questionnaire FACIT-Sp and any of the demographic variables. We observed significant correlations between higher scores of spirituality (ANOVA p &lt; 0.001) with the absence of depression. Likewise higher scores of QOL (ANOVA p &lt; 0.001) correlated with lack of depression. By multiple regression analysis both the spirituality dominion of the FACIT-Sp and the Beck depression inventory score correlated independently and significantly with general QOL measured by the FACT-G questionnaire’s score (p = 0.025 and p = 0.004, respectively). Conclusions: Despite the small sample size of our study, it was possible to show that religion is highly regarded by our patients and that it may influence their quality of life independently from depression. Furthermore, spirituality may also be a protective factor against depression. Therefore, physicians respect and encourage their religious practices. No significant financial relationships to disclose.
Abstract 9798: The E3 lLgase Asb2 Regulates Cardiac Development Through Targeting Smad9 for Proteasomal Degradation
Authors: Kyung-Duk Min, Masanori Asakura, Shin Ito, Manabu Shirai, Satoru Yamazaki, Hiroshi Asanuma, Naoki Mochizuki, Masafumi Kitakaze
Journal: Circulation (2013)

A growing body of evidence revealed that temporal regulation of transcriptional factors is crucially required for cardiac development. Although the induction of transcription factors such as Nkx2.5 and Tbx5 has been of particular interest, the role and mechanism of their timely down-regulation during cardiac development is not fully elucidated. We hypothesized that E3 ligase-dependent degradation of transcription factors plays crucial roles in cardiac development. To identify key E3 ligases regulating cardiac development, we induced three different populations of cardiomyocytes from murine embryonic stem cells treated with any of Noggin, Frizzled or vehicle. We analyzed the temporal changes in gene expressions of them and finally identified an E3 ligase, namely ankyrin repeat and socs box protein2 (Asb2). Both whole mount in situ hybridization of mouse embryos and subsequent RT-PCR revealed that the Asb2β transcript, an isoform of Asb2, is present predominantly in heart during the early embryonic stage. We found that Smad9, an intracellular transducer of the bone morphogenetic protein signals, interact with Asb2β. Biochemical analysis revealed that Asb2β specifically ubiquitinate Smad9, but not Smad1/5. Pulse chase analysis demonstrated that Smad9 was targeted for proteasomal degradation by Asb2β. Knockdown of zebrafish asb2 using morpholino caused significant thinning of the ventricular wall (3.6 ± 0.9 vs. 8.7 ± 1.0μm, p &lt;0.01 ) and remarkable dilatation of the ventricular diameter (23.7 ± 1.1 vs. 11.3 ± 0.7μm, p&lt;0.01 ) compared with wild type siblings. Importantly, simultaneous knockdown of smad9 rescued the impairment of cardiac development due to asb2 knockdown in zebrafish, whereas single knockdown of smad9 caused no abnormal phenotype. These results imply that the suppression of Smad9 is crucial for cardiac development. Also we confirmed that forced expressions of Smad9 in P19CL6 cells failed in cardiac differentiation while that of Asb2β did not affect their fate. We conclude that the accumulation of Smad9 critically impairs the cardiac development and the temporal degradation of Smad9 mediated by E3 ligase Asb2 is critically required for cardiognesis.
临床证据（一）慢性阻塞性肺疾病的治疗效果
Authors: 朱亚玲, Kerst.
Journal: BMJ (2001)

从本期始 ,我们将在“循证医学”栏目中连载选自最新版《临床证据》的内容。《临床证据》一书由英国医学杂志出版集团编纂 ,其方法严谨 ,保证了证据的可靠性和适用性 ,为临床治疗决策提供了依据 ,同时 ,还为临床医生节省了自己检索和评估文献所花费的时间和精力。我们希望《临床证据》的连载有助于读者理解“循证医学”这一概念 ,把循证医学与临床工作结合起来。本栏目中的“与循证医学相关的名词及其解释” ,将连续对《临床证据》中的术语和英文缩写词汇做简明的定义和诠释 ,以飨读者
Abstract 8990: Bivalvular Transcatheter Treatment of Patients with Concomitant Aortic Stenosis and Mitral Regurgitation
Authors: Stephan Baldus, Hendrik Treede, Olaf Franzen, Volker Rudolph, Johannes Schirmer, Malgorzata Knap, Michael Schlüter, Hermann Reichenspurner, Stefan Blankenberg
Journal: Circulation (2011)

Transcatheter techniques to treat severe aortic stenosis (AS) or significant mitral regurgitation (MR) in patients deemed at high surgical risk have shown to be safe and efficacious in either clinical entity. For AS, transcatheter aortic valve replacement (TAVR) using the Sapien/Sapien XT prosthesis (Edwards Lifesciences) via transfemoral (TF) or transapical (TA) access or the CoreValve prosthesis (Medtronic) via TF access has become a viable therapeutic option, whereas in MR, considerable clinical experience has been gained with transvenous/transseptal implantation of the MitraClip (MC) device (Abbott Vascular). To date, little information is available on transcatheter treatment for both AS and MR in the same patient. By May 2011, 263 TAVR and 233 MC procedures had been performed at our center. Eleven patients (78 ± 6 years, 9 men [82%]) underwent both TAVR and MC implantation. In the first 8 patients treated, TAVR (5 TA, 3 TF) preceded MC by a median of 84 (range, 4 to 348) days, whereas in the last 3 patients TAVR (1 TA, 2 TF) and, subsequently, MC were performed in a single session. All TAVR procedures (7 Sapien [n=4]/Sapien XT [n=3], 4 CoreValve prostheses) were successfully completed, resulting acutely in a significant increase in effective orifice area from 0.90 ± 0.12 to 1.82 ± 0.58 cm 2 ( P = 0.0114) and a significant decrease in mean transaortic pressure gradient from 22 ± 10 to 7 ± 2 mmHg ( P = 0.0077). MC implantation (1 clip, n=8; 2 clips, n=2; 3 clips, n=1) succeeded in reducing MR severity to &lt;=2+ in 10 patients (MR 1+, n=5; MR 2+, n=5); in 1 patient, MR severity remained at 3+ despite placement of 2 clips. Permanent pacemaker implantation was required in 5 patients (4 Sapien/Sapien XT, 1 CoreValve); 1 patient sustained a stroke 19 days after bivalvular treatment in a single session. Post TAVR, no patient had transvalvular aortic regurgitation (AR); minor (grade 1) paravalvular AR was present at discharge in 8 patients. Patients were followed for a median of 210 (range, 69 to 398) days. Two patients (18%; 95% CI, 2% to 52%) died of persistent cardiac decompensation at 73 and 398 days after successful bivalvular treatment. We conclude that bivalvular transcatheter treatment of concomitant AS and MR is feasible, efficacious and safe, even if performed in a single session.
N1-methylpseudouridine-incorporated mRNA outperforms pseudouridine-incorporated mRNA by providing enhanced protein expression and reduced immunogenicity in mammalian cell lines and mice
Authors: Oliwia Andries, Séan Mc Cafferty, Stefaan C. De Smedt, Ron Weiss, Niek N. Sanders, Tasuku Kitada
Journal: Journal of Controlled Release (2015)
Abstract 245: AZD6140 Inhibits Adenosine Uptake Into Erythrocytes and Enhances Coronary Blood Flow After Local Ischemia or Intracoronary Adenosine Infusion
Authors: Jan-Arne Bjorkman, Ian Kirk, J J van Giezen
Journal: Circulation (2007)

Background. Adenosine is one of the mediators of the reactive hyperemia response to temporary coronary artery occlusion. AZD6140, a reversible oral P2Y12 receptor antagonist, in a routine selectivi...
Abstract 14339: F 16618, A New Par1 Antagonist Prevents Restenosis by Inhibiting Migration and Proliferation of Smooth Muscle Cells.
Authors: Pauline Chieng Yane, Arnaud Bocquet, Robert Létienne, Thierry Bourbon, Sylvie Sablayrolles, Michel Perez, Stéphane Hatem, Anne-Marie Lompré, Monique David-Dufilho, Bruno Le Grand
Journal: Circulation (2010)

Objectives: Wound healing responses after angioplasty or stenting are associated with increased production of thrombin and activation of protease activated receptor 1 (PAR1). The aim of the present...
Anxiogenic effects of caffeine on panic and depressed patients
Authors: M A Lee, P Flegel, J F Greden, O G Cameron
Journal: American Journal of Psychiatry (1988)

Caffeine increases anxiety in people with anxiety disorders. To determine whether caffeine exerts a similar effect in depression, the authors compared retrospective reports of caffeine intake and symptoms produced by caffeine ingestion in patients with panic disorder, patients with major depression, and control subjects. Panic patients consumed less caffeine and reported more symptoms than depressed or control subjects. Although depressed patients did not differ from control subjects in caffeine intake or most symptoms, more depressed patients reported that caffeine induced anxiety. These data support prior reports that panic patients have increased sensitivity to caffeine; some depressed patients may also have increased sensitivity.
Abstract 11048: Downregulation of HCN4 and the Pacemaker Current (If) Underlies Exercise Training-Induced Sinus Bradycardia
Authors: Alicia D’Souza, Annalisa Bucchi, Halina Dobrzynski, Anne Berit Johnsen, Oliver J Monfredi, Sukhpal Prehar, George Hart, Elizabeth J Cartwright, Ulrik Wisloff, Dario Difrancesco, Gwilym M Morris, Mark R Boyett
Journal: Circulation (2013)

Background: Sinus bradycardia, the most common arrhythmia in endurance athletes, is usually attributed to heightened vagus nerve activity. This may become maladaptive; endurance athletes have a hig...
Abstract 1437: The Chromosome 9p21 Risk Locus is Associated with a Greater Severity of Angiographically Defined Coronary Artery Disease
Authors: Riyaz S Patel, Jinying Zhao, Felicia M Warren, Imrana Qureshi, Ibhar Al Mheid, Douglas C Morris, Habib Samady, Salina P Waddy, Anna Helgadottir, Jeffrey Gulcher, Viola Vaccarino, A Maziar Zafari, Arshed A Quyyumi
Journal: Circulation (2008)

Background: Large-scale genome wide association studies have demonstrated a risk locus at position 9p21 conferring a 1.3–1.5 fold risk of MI and incident CAD in Caucasian populations with an allele...
Coronary Arterial 18F-Sodium Fluoride Uptake
Authors: Marc R. Dweck, Marcus W.L. Chow, Nikhil V. Joshi, Michelle C. Williams, Charlotte Jones, Alison M. Fletcher, Hamish Richardson, Audrey White, Graham McKillop, Edwin J.R. van Beek, Nicholas A. Boon, James H.F. Rudd, David E. Newby
Journal: Journal of the American College of Cardiology (2012)
Asthma in Pregnancy
Authors: Michael Schatz, Mitchell P. Dombrowski
Journal: New England Journal of Medicine (2009)

A 23-year-old nonsmoking woman (gravida 1, para 0) presents at 11 weeks' gestation with an 8-year history of asthma, which has worsened over the past year. She reports symptoms requiring albuterol two or three times per day and interfering with sleep. Her forced expiratory volume in 1 second is 75% of the predicted value; it increases to 88% after administration of albuterol. How should her case be managed?
Abstract 3634: Association of Weight Loss and Changes in Left Ventricular Geometry and Function - Results of the longitudinal population based MONICA/KORA-Survey
Authors: Jan Stritzke, Marcello R Markus, Wolfgang Lieb, Andreas Luchner, Angela Döring, Ulrich Keil, Heribert Schunkert
Journal: Circulation (2007)

Background: Obesity is related to left ventricular (LV) hypertrophy and diastolic dysfunction. However it remains unclear if changes in life style resulting in loss of body weight also have beneficial effects on left ventricular remodeling. In this study we evaluated the effects of weight loss on left ventricular geometry and function during ten years of follow-up. Methods: Subjects (n=1005, aged 25 to 74 years) who originated from a gender and age stratified random sample of German residents of the Augsburg area were examined by standardized echocardiography at baseline and again after ten years. The associations between weight loss and long-term changes of left ventricular end-diastolic diameter (LVEDD), wall thickness (WT), left ventricular mass (LVM), and left atrial diameter (LA) were assessed. Mean relative changes and odds ratios were computed by statistical models adjusting for gender, age, body height, systolic blood pressure and body weight at baseline. Results: After ten years of follow-up 305 individuals presented with a loss of body weight (−3.5+/−3.4kg on average). Whereas 700 subjects presented with an increase of body weight (+5.4+/−4.7kg). Ageing related changes in LV geometry were significantly different in the two groups. Specifically, individuals with weight loss displayed a favorable geometry with relative changes of WT (+5.9% [CI-95% 4.3, 7.5] vs. + 8.1% [7.0, 9.2], p=0.024), LVEDD (−0.6% [−1.5, 0.2] vs. 30.8% [0.2, 1.4], p=0.008), LVM (+6.5% [4.3, 8.8] vs. +11.9% [10.4, 13.5], p&lt;0.001) and LA (−0.9% [−2.1, 0.2] vs. +2.5% [1.7, 3.3], p&lt;0.001), as compared to individuals with weight gain. Moreover, the risk for incident left ventricular hypertrophy (OR 2.5 [1.5– 4.3], p=0.001) and incident diastolic dysfunction (OR 1.9 [1.1–3.4], p=0.023) was significantly higher in individuals presenting with an increase in body weight. Conclusions: As compared to weight gain, weight loss is associated with a significant deceleration of left ventricular remodeling during ageing of the heart. Nevertheless, even in the weight loss group there was no regression in left ventricular mass detectable. Consequently, early interventions especially in young obese individuals are essential for prevention of premature onset of cardiac remodeling.
Role of BAFF in Adhesion and Growth of Human Multiple Myeloma Cells in the Bone Marrow Microenvironment.
Authors: Yu-Tzu Tai, Xian-Feng Li, Rory Coffey, Iris Breitkreutz, Laurence Catley Laurence Catley, Klaus Podar, Teru Hideshima, Dharminder Chauhan, Noopur Raje, Robert Schlossman, Paul Richardson, Nikhil C. Munshi, Kenneth C. Anderson
Journal: Blood (2005)
Most people are not disgusted by the Portman group
Authors: J. Rae
Journal: BMJ (1995)

EDITOR,—To bracket the Portman Group with an organisation such as Forest is grossly unfair, as anyone familiar with the group's activities will know.1 It is untrue to say that most people are “disgusted” by our activities. On the contrary, our participation in a wide range of prevention projects has been welcomed by everyone who recognises that the drinks industry has …
P0445 : Obeticholic acid, an FXR agonist, reduces hepatic fibrosis in a rat model of toxic cirrhosis
Authors: L.D. Verbeke, I. Mannaerts, R. Schierwagen, S. Klein, I. Vander Elst, P. Windmolders, R. Farre, M. Wenes, M. Mazzone, F. Nevens, L.A. van Grunsven, J. Trebicka, W. Laleman
Journal: Journal of Hepatology (2015)
Complement
Authors: Mark J. Walport
Journal: New England Journal of Medicine (2001)

Complement at the Interface between Innate and Adaptive ImmunityThe formation of an antibody–antigen complex (immune complex) is the principal way of activating the classical pathway of the complement system. C1q, an integral part of the first component of complement (C1), triggers the activation process when it docks onto antibodies within these immune complexes. In this way, C1q acts to bridge the innate and adaptive immune systems.Complement also has an important role in the induction of antibody responses.62 This was shown first by Pepys, who demonstrated that the formation of antibodies against T-cell–dependent antigens was reduced in animals in . . .
Transient Response to Imatinib in an Atypical Chronic Myeloproliferative Disease Associated with ins(9;4)(q34;q21q31) and a CDK5RAP2-PDGFRA Fusion Gene.
Authors: Christoph Walz, Beate Schultheis, Georgia Metzgeroth, Claudia Schoch, Claire Curtis, Eva Lengfelder, Torsten Haferlach, Ute Berger, Andreas Hochhaus, Rüdiger Hehlmann, Nicholas C.P. Cross, Andreas Reiter
Journal: Blood (2005)