Disease and the HL-A Histocompatibility System
Authors: Fritz H. Bach
Journal: Annals of Internal Medicine (1971)

Editorials1 December 1971Disease and the HL-A Histocompatibility SystemFRITZ H. BACH, M.D.FRITZ H. BACH, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-75-6-962 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTHE HL-A system, the major histocompatibility locus in man analogous to the H-2 system in the mouse, has attracted the attention of many different groups. Human geneticists have found in HL-A a highly polymorphic system of yet unknown organization possibly involving gene duplication with linkage disequilibrium. The puzzle remains as to what mechanisms may account for a selective advantage to maintain the polymorphism. Immunologist-cell biologists have been intrigued by the perhaps unique presentation of these antigens in immunological reactions (the high frequency of responding cells to HL-A antigens), their very strong influence on reactions such as the homograft response, and...References1. WALFORDSMITHWATERS RGH: Histocompatibility systems and disease states, with particular reference to cancer. Transplantation Rev. In press Google Scholar2. LILLY F: Fv-2: identification and location of a second gene governing the spleen focus response to Friend leukemia virus in mice. Natl Cancer Inst 45:163-169, 1970 Google Scholar3. LILLY F: The histocompatibility-2 locus and susceptibility to tumor induction. Natl Cancer Inst Monogr 22:631-642, 1966 MedlineGoogle Scholar4. AMIEL J: Study of the leukocyte phenotypes in Hodgkin's Disease, in Histocompatibility Testing 1967, edited by CURTONI ES, MATTIUZ PL, TOSI RM. Copenhagen, Ejnar Munksgaards Forlag, 1967, p. 79-86 Google Scholar5. FALKOSOBA JD: Personal communication Google Scholar6. WALFORDZELLERCOMBS REL: HL-A specificities in acute and chronic lymphatic leukemia. Transplantation Proc. In press Google Scholar7. WALFORD R: Antibody diversity, histocompatibility systems, disease states, and ageing. Lancet 2:1226-1229, 1970 CrossrefMedlineGoogle Scholar8. MILLER R: Simultaneous Statistical Inference. New York, McGraw-Hill Book Co., Inc., 1966, p. 8 Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Department of Medical Genetics College of Agricultural and Life Sciences, The University of Wisconsin Madison, Wis.*The author is an Established Investigator of the American Heart Association. This is Paper No. 1514 from the Laboratory of Genetics, University of Wisconsin, Madison, Wis. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byHLA antigens and Graves' disease in Black South AfricansA Study of HLA in Japanese Patients with Rheumatic FeverBladder Cancer: Pebbles to Reach the WaterThe Association of Histocompatibility Antigens of the B7 Cross-Reacting Group with Peyronie’s DiseaseHistocompatibility antigens in systemic lupus erythematosusIncomplete Reiter's Syndrome: Discriminating Features and HL-A W27 in DiagnosisFRANK C. ARNETT, M.D., O. EDWIN McCLUSKY, BERNICE Z. SCHACTER, Ph.D., ROBERT E. LORDONIMPAIRED IMMUNORESPONSIVENESS IN TUMOR PATIENTS 1 December 1971Volume 75, Issue 6Page: 962-964KeywordsAntigensBiologistsCardiovascular therapyCellsDisequilibriumGeneticsHeart diseasesHistocompatibilityHomograftsResearch laboratories ePublished: 1 December 2008 Issue Published: 1 December 1971 PDF downloadLoading ...