tbuckley/cabot-search huggingface dataset:
Abstract 4157: Autosome instability and loss of chromosome Y in blood lymphocytes predict lung cancer risk
Authors: Bing Sun, Ying Wang, Krishna Kota, Yaru Shi, Kepher H. Makambi, Christopher A. Loffredo, Peter G. Shields, Curtis C. Harris, Yun-Ling Zheng
Journal: Cancer Research (2014)

Abstract Background: Cancer cells are characterized by frequent chromosome aberrations (CA), which reflect defects of the underlying mechanisms that maintain genomic stability. Chromosome aberrations in peripheral blood lymphocytes has been shown to be associated with overall cancer risk in previous small studies. However, the relationship between types of chromosome aberrations in blood lymphocytes and lung cancer risk has not been well defined. In a case-control study of non-small cell lung cancer, we evaluated if CA in autosomes and sex chromosomes were predictive of lung cancer risk. Method: Chromosome aberrations were determined by G-banding analysis of metaphase chromosomes from short-term cultured blood lymphocytes. Logistic regression was used to estimate the strength of association between CAs and lung cancer risk. Results: Autosome instability (defined as CA in any of the 22 pairs of autosomes in &amp;gt; 5% of the cells) was significantly associated with lung cancer risk among individuals who were &amp;lt;= 67 years of age; adjusted odds ratio (OR) of 5.0 [95% confidence interval (CI) = 1.6 - 15.3]. There was no significant association between autosome instability and lung cancer risk in individuals who were older than 67 years of age. Loss of chromosome Y was significantly associated with an elevated risk of lung cancer among males; adjusted OR of 3.2 (95% CI = 1.2 - 8.8). This association appeared to be stronger in older males (&amp;gt; 67 years of age) and in African American males. We observed no significant association between loss of chromosome X and lung cancer risk in both males and females. Conclusion: Autosome instability and loss of chromosome Y in blood lymphocytes were significantly associated with lung cancer risk. Analysis of chromosome aberrations in blood lymphocytes may be a promising tool for the identification of sub-population who are at high risk of developing lung cancer. Citation Format: Bing Sun, Ying Wang, Krishna Kota, Yaru Shi, Kepher H. Makambi, Christopher A. Loffredo, Peter G. Shields, Curtis C. Harris, Yun-Ling Zheng. Autosome instability and loss of chromosome Y in blood lymphocytes predict lung cancer risk. [abstract]. In: Proceedings of the 105th Annual Meeting of the American Association for Cancer Research; 2014 Apr 5-9; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2014;74(19 Suppl):Abstract nr 4157. doi:10.1158/1538-7445.AM2014-4157
Abstract 15294: Activation of Mac-1 Integrin Prevents G-CSF Mediated Monocyte Mobilization and Atherosclerosis Severity in Hypercholesterolemic Mice
Authors: Sina Rahimpour, Annia Mesa, Lei Song, Natasha Fernandez, Si M Pham, Vineet Gupta, Roberto Vazquez
Journal: Circulation (2014)

Background: Leukadherins (LA) are a novel family of Mac-1 agonists that increase cell adhesion and prevent leukocyte mobilization and tissue inflammation. This study brings new insights into how leukadherin LA1 protects hypercholesterolemic ApoE-null mice from excessive atherosclerosis development. Hypothesis: Activation of Mac-1 integrin with leukadherin LA1 retains monocytes in medullary and extramedullary centers and therefore, controls high fat diet induced monocytosis and atherosclerosis in ApoE-null mice. Methods and Results: Once daily administration of LA1 (10mg/kg) for 16 weeks significantly reduced atherosclerosis in the entire aorta and the aortic valve of high fat diet fed ApoE-null mice as determined by Sudan IV staining. The LA1 treatment had not effect on body weight or plasma lipid levels though it significantly reduced the number of circulating monocytes (Lin2- CD11c- CD11b+ by FACS). The remaining circulating monocytes in LA1-treated mice displayed low levels of Ly6C, a marker for inflammation. Interestingly, LA1 caused monocyte retention in the bone marrow (BM) and macrophages (F4/80+ by IHC) in the spleen of hypercholesterolemic mice, which account for the low numbers of monocytes seem in the circulation of these mice. On the other hand, the excessive number of BM monocytes didn’t compromise the number of hematopoietic (Lin- Sca+ c-Kit+) or myeloid (Lin- Sca- c-Kit+) progenitor cells. Finally, we assessed the effect of LA1 on systemic inflammatory mediators using multiplex immunoassay. The plasma levels of G-CSF, one of the main monocyte mobilization cytokines capable of promoting atherosclerosis in ApoE-null mice, were found reduced in a half in treated versus control mice. Conclusions: These data demonstrate that Mac-1 activation with LA1 significantly reduces atherosclerosis in hypercholesterolemic ApoE-null by impairing G-CSF mediated monocyte mobilization from medullary and extramedullary centers.
Book: Epidemiology Kept Simple: An Introduction to Classic and Modern Epidemiology
Authors: D. Batty
Journal: BMJ (1999)

B Burt Gerstman Wiley-Liss, £25.95, pp299 ISBN 047124029X Rating: ![Graphic][1]</img>![Graphic][2]</img>![Graphic][3]</img> Epidemiology is an eclectic discipline comprising facets of sociology, statistics, medicine, and demography. Although its development may be traced back to the scientific revolution of the 1600s, it was not until the 19th century that it was recognised as a subject area in its own right. Knowledge of the occurrence, aetiology, and subsequent control of communicable diseases such as typhoid fever, smallpox, and cholera stemmed from early epidemiological studies. Indeed, … [1]: /embed/inline-graphic-1.gif [2]: /embed/inline-graphic-2.gif [3]: /embed/inline-graphic-3.gif
Abstract 13909: Interruption of Novel Inter-domain Interaction Within RyR2 as a Common Therapeutic Target by Channel Stabilization in Heart Failure and Catecholaminergic Polymorphic Ventricular Tachycardia (CPVT)
Authors: Takeshi Yamamoto, Masafumi Yano, Masahiro Fukuda, Akihiro Hino, Takeshi Suetomi, Masahiro Doi, Shinich Okuda, Shigeki Kobayashi, Masunori Matsuzaki
Journal: Circulation (2010)

We recently reported that K201(JTV519) specifically binds to domain2114–2149 of the ryanodine receptor (RyR2) and stabilizes the channel. Here, we further characterized the role of this novel domain on the channel gating in tachycardia induced canine heart failure model and human CPVT-associated RyR2 R2474S/+ knock-in (KI) mice model. Methods and results: Using a synthetic peptide matching domain2114–2149 of RyR2 (DP2114–2149) as a site-directing carrier, either recombinant fragments (1–610, 741–1260, 1245–1768, 1741–2270, 2234–2750) of RyR2, or canine RyR2 was fluorescently labeled with methylcoumarin acetate (MCA). Of these recombinant RyR2 fragments, only fragment2234–2750 was specifically MCA-labeled. After tryptic digestion of this MCA-labeled fragment, domain2234–2370 (14.8 kDa) was further identified as the shortest MCA-labeled fragment. The MCA-labeling of the 155kDa tryptic fragment (harboring domain2234–2370) in canine RyR2 was also confirmed. Addition of DP2114–2149 to the MCA-labeled canine Ry...
Allergy: Principles and Practice.
Authors: Elliott Middleton, Charles E. Reed, Elliot F. Ellis
Journal: Annals of Internal Medicine (1991)

Volume 1: immunology biology of eosinophils pathophysiology of allergic inflammation physiology pharmacology principles of therapeutics theophylline antihistamines cromolyn and nedocromil antocholinergic agents. Volume 2: clinical science cell-mediated immunity in health and disease immune complexes and allergic disease immunologic deficiency and allergic disease clinical significance of IgE eosinophilia and eosinophili-related disorders development and prevention of allergic disease in childhood asthma - definition and pathogenesis airway hyperresponsiveness pathology of asthma immunotherapy insect allergy anaphylaxis ocular allergy.
Midline episiotomy and anal incontinence
Authors: C. Chaliha
Journal: BMJ (2000)

Editor—The finding by Signorello et al that midline episiotomy may impair anal continence is valuable and highlights the effect of perineal trauma on the anal continence mechanism.1 The authors acknowledge the limitations of the study, which was retrospective, non-randomised, and may have included misclassifications of perineal trauma.

We investigated 161 nulliparous women in the third trimester and 12 weeks post partum. A symptom questionnaire and anorectal investigations were performed at both visits and anal endosonography was performed post partum.2

Women with an intact perineum had a mean squeeze pressure of 105.8±26.4 mmHg, those who sustained second and third degree perineal tears had a mean squeeze pressure of 92.3±30.3 mmHg (P=0.022), and those who had mediolateral episiotomies had a mean squeeze pressure of 92.2±29.7 mmHg (P=0.032).

Sphincter trauma was associated with perineal trauma at delivery: of 59 women with second or third degree tears, 41 (69%) had sphincter trauma versus 39 out of 97 women (40%) with an intact perineum (P=0.001). Sphincter trauma was also significantly more common in women who underwent vaginal delivery: 58 out of 130 (45%) women had sphincter defects in the vaginal delivery group versus 1 out of 26 women (4%) women who underwent a caesarean section (P=0.0005). However, the difference between our study and that of Signorello et al is that the patients in our study had a mediolateral and not a midline episiotomy, and it is well known that midline episiotomy is associated with a higher risk of extension to the anal sphincter.

Our study has confirmed previous reports that show that the incidence of sphincter damage increases considerably when an episiotomy occurs together with a perineal tear.3 The association of any perineal trauma, either an episiotomy or a spontaneous tear, with sphincter defects has important implications for obstetric practice as sphincter trauma has been linked directly to the development of anal incontinence.4 Methods to minimise perineal trauma such as the use of the ventouse rather than the forceps and the correct management of the active second stage once the head is crowning should be encouraged.

Recognition of perineal trauma is known to be poor and this may lead to inadequate repair and predispose to the development of incontinence.5 Doctors and midwives both need improved and focused training in the recognition and repair of sphincter trauma.
Dr. Ronald B. Herberman's Reply: Antibodies and Cancer
Authors: R. B. Herberman
Journal: CA A Cancer Journal for Clinicians (1983)

Antibodies and Cancer To the Editor:Itis well known thatartificial or semi artificial antibodies are being developed against cancer.There is also a strong school of thought that behieve@ that we are con stantly being exposed to antigens, but that our immune mechanisms fight them off.The ideaoccurred tome: Why notusena ture's own methods?My idea is simply to take two subjects with different cancers (suchas lymphoma versussquamous cell) of thesame bloodtypeand crosscirculate their blood.Each should develop antibod ies against the other's tumor.Of course, this should probably be tried first on a voluntary basis in terminally ill patients or in animals.And, of course, the length of time required and side effects would have to be tested.But I can find no studyof thiskind and would appreciate your thoughts.
Regulation of Jak2 tyrosine kinase by protein kinase C during macrophage differentiation of IL-3–dependent myeloid progenitor cells
Authors: Panu E. Kovanen, Ilkka Junttila, Kati Takaluoma, Pipsa Saharinen, Leena Valmu, Weiqun Li, Olli Silvennoinen
Journal: Blood (2000)
Education Through Physical Activities: Physical Education and Recreation for Elementary Grades
Authors: Pattrice Ruth O'Keefe, Anita Aldrich
Journal: JAMA (1949)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Heartburn and Bethanechol
Authors: Armand Littman
Journal: Annals of Internal Medicine (1974)

Editorial Notes1 May 1974Heartburn and BethanecholARMAND LITTMAN, M.D.ARMAND LITTMAN, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-80-5-664 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThis issue welcomes oral bethanechol (Urecholine®*) as a potentially useful treatment for patients with heartburn who have not been helped with conventional measures. At the Naval Hospital in Philadelphia, Farrell, Roling, and Castell (1) have convincingly shown that patients with this therapeutically difficult condition get significant relief that is apparently not otherwise obtainable. Which patients should be treated with bethanechol? Will bethanechol work in your patients and mine? Some aspects of the design of this study weaken one's confidence in the conclusions and some aspects strengthen it. As with most literature on therapy of gastrointestinal disease—caveat emptor.The population studied...Reference1. FARRELLROLINGCASTELL RGD: Stimulation of incompetent lower esophageal sphincter. A possible advance in therapy of heartburn. Am J Dig Dis 18:646-650, 1973 CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Veterans Administration Hospital Hines, Illinois*Merck Sharpe and Dohme, West Point, Pennsylvania. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 May 1974Volume 80, Issue 5Page: 664-665KeywordsPatients ePublished: 1 December 2008 Issue Published: 1 May 1974 PDF downloadLoading ...
A candidate prostate cancer susceptibility gene at chromosome 17p
Authors: Sean V. Tavtigian, Jacques Simard, David H.F. Teng, Vicki Abtin, Michelle Baumgard, Audrey Beck, Nicola J. Camp, Arlene R. Carillo, Yang Chen, Priya Dayananth, Marc Desrochers, Martine Dumont, James M. Farnham, David Frank, Cheryl Frye, Siavash Ghaffari, Jamila S. Gupte, Rong Hu, Diana Iliev, Teresa Janecki, Edward N. Kort, Kirsten E. Laity, Amber Leavitt, Gilles Leblanc, Jodi McArthur-Morrison, Amy Pederson, Brandon Penn, Kelly T. Peterson, Julia E. Reid, Sam Richards, Marianne Schroeder, Richard Smith, Sarah C. Snyder, Brad Swedlund, Jeff Swensen, Alun Thomas, Martine Tranchant, Ann-Marie Woodland, Fernand Labrie, Mark H. Skolnick, Susan Neuhausen, Johanna Rommens, Lisa A. Cannon-Albright
Journal: Nature Genetics (2001)
Mutations in the gene encoding the latency-associated peptide of TGF-β1 cause Camurati-Engelmann disease
Authors: Katrien Janssens, Ruth Gershoni-Baruch, Nuria Guañabens, Nicola Migone, Stuart Ralston, Maryse Bonduelle, Willy Lissens, Lionel Van Maldergem, Filip Vanhoenacker, Leon Verbruggen, Wim Van Hul
Journal: Nature Genetics (2000)
Ramping Up Rehabilitation Research Urged as a “Public Health Imperative”
Authors: Rebecca Voelker
Journal: JAMA (2005)

CHICAGO—Three years ago, the journal Science featured a series of articles describing the wonders of bioengineering and bionics and the promise they hold for mending bodies broken by spinal cord injuries, stroke, and diseased joints and organs. But even as many of these wonders are being put to the test in clinical trials, clinicians and basic scientists in the field of disability rehabilitation are facing challenges that even the Six Million Dollar Man might find difficult to overcome. During the joint conference of the American Congress of Rehabilitation Medicine and the American Society of Neurorehabilitation here in late September, experts debated not only sophisticated techniques such as the use of cortical stimulation to aid stroke recovery but also some fundamental issues concerning current research capacity in rehabilitation medicine. Rory Cooper, PhD, professor and chair of rehabilitation science and technology in the School of Health and Rehabilitation Sciences at the University of Pittsburgh, in Pennsylvania, told his colleagues that the field currently lacks many of the resources needed to achieve the objectives described in Science’s February 8, 2002, issue on “The Bionic Human.” He said resources that are in short supply include federal funding, an ample pool of well-trained investigators, mentors for young investigators entering the field, and new tools to measure rehabilitation outcomes. “This is a public health imperative,” Cooper said, noting that in the next 25 years an estimated 20% of the US population will be aged 65 years or older. “Disability rehabilitation research is a quality of life issue, as well as a technology issue and a medical care issue.”
Comparison of the performance of serological kits for Helicobacter pylori infection with European and Asian study populations
Authors: T.T.H. Hoang, A.-S. Rehnberg, T.-U. Wheeldon, C. Bengtsson, D.C. Phung, R. Befrits, M. Sörberg, M. Granström
Journal: Clinical Microbiology and Infection (2006)
Relative Blood Volume Changes Following the Use of Intravenous Glucose Injections in Pneumonia
Authors: John H. L. Heintzelman
Journal: Annals of Internal Medicine (1931)

Article1 April 1931Relative Blood Volume Changes Following the Use of Intravenous Glucose Injections in PneumoniaJOHN H. L. HEINTZELMAN, M. D.JOHN H. L. HEINTZELMAN, M. D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-4-10-1336 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptAt the present time, as glucose solutions are used intravenously in certain diseases, particularly in pneumonia, the effect produced on the vascular mechanism is of paramount interest.A review of the literature on the subject of blood volume changes following intravenous injections of hypertonic glucose solutions shows that the majority of investigators demonstrated an increase in the volume12456. Two writers state that there is no change in the blood volume following glucose injections37. Such investigations have been chiefly on animals. The conclusions were based on comparatively few observations, and these were not uniform.Twenty-six relative blood volume determinations were made8....References1 LEATHERS JB: Some Experiments on the Exchange of Fluid Between the Blood and Tissues, J. Physiol., 19: 1, 1896. CrossrefGoogle Scholar2 STARLING EH: The Glomerular Function of the Kidney, Am. J. Physiol., 24: 317, 1899. CrossrefGoogle Scholar3 BOGERTUNDERHILLMENDEL LJTPLB: The Regulation of Blood Volume After Injections of Saline Solutions, Am. J. Physiol., 41: 189-233, 1916. CrossrefGoogle Scholar4 ERLANDERWOODYATT JET: Intravenous Glucose Injections in Shock, J. A. M. A., 69: 1410, 1917. CrossrefGoogle Scholar5 GASSERERLANGER HSJ: Studies in Secondary Traumatic Shock, Am. J. Physiol., 50:104, 1919. CrossrefGoogle Scholar6 ALLENWISHART JMMB: Experiments in Carbohydrate Metabolism and Diabetes, J. Biol. Chem., 42:415, 1920. CrossrefGoogle Scholar7 MATTILLMAYERSAUER PMKLW: The Influence of Intravenous Injection of Acacia Glucose Solutions on Urine Excretion and Blood Volume in Rabbits, J. Pharmacol. Exp. Ther., 16: 391-400, 1920. Google Scholar8 From the Medical Service of Dr. W. W. G. Maclachlan, Mercy Hospital. Google Scholar9 ALBRITTON EC: Blood Sugar and Hemoglobin After Intravenous Glucose, Am. J. Physiol., 68:542-556, 1924. CrossrefGoogle Scholar10 FOSHAY LJ: The Relation of Hyperglycemia to the Blood Volume, Chlorine Concentration, and Chlorine Distribution in Dogs, J. Exp. Med., 42: 89-98, 1925. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Pittsburgh*From the Department of Physiology, School of Medicine, University of Pittsburgh. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 April 1931Volume 4, Issue 10Page: 1336-1339KeywordsBlood volumeGlucoseIntravenous injectionsPneumoniaVascular diseases ePublished: 1 December 2008 Issue Published: 1 April 1931 PDF downloadLoading ...
Mechanism of Growth II. The Influence of p-Dimethylaminoazobenzene on Rat Liver Regeneration after Partial Hepatectomy
Authors: Sam Brody
Journal: Cancer Research (1960)

The immediate and prolonged effects of p -dimethylaminoazobenzene on the increase in weight, net amount of pentose- and deoxypentosenucleic acids and acid deoxyribonuclease activity in the rat liver after partial hepatectomy have been studied.

A slight depression of the rate of dry weight increase was noted after feeding DAB to the rats for 60 days. Discontinuation of the carcinogen brought about normal conditions. No immediate or prolonged effects of DAB on the rate of PNA formation were recorded. A considerable reduction of the rate of DNA formation was found after only 25 days' administration of DAB. The same reduction was found at 60 days, but a return to normal conditions was noted after discontinuation of the carcinogen. An initial stimulation of the postoperative DNase increase was demonstrated. This stimulation after 25 days' administration of DAB was followed by a depression at 60 days. The DAB-induced reduction of the capacity of the liver cells to respond to a growth stimulus with an increase in the average cellular DNase activity was sustained even after discontinuation of the carcinogen.
Abstract 20638: Obstructive Sleep Apnea causes Interatrial Conduction Delay
Authors: Ken-ichi Maeno, Takatoshi Kasai, Satoshi Kasagi, Sugao Ishiwata, Minoru Ohno, Tetsu Yamaguchi, Koji Narui
Journal: Circulation (2010)

Background: Prolonged P wave duration, which means interatrial conduction delay (ICD), is a marker of left atrial abnormality and reported as a potent precursor of atrial fibrillation (AF). On the ...
Germline Gene Mutation May Increase Leukemia Risk
Authors: Tracy Hampton
Journal: JAMA (2015)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal