Median Incubation Time for Human Immunodeficiency Virus (HIV)
Authors: Warren Winkelstein, Rachel A. Royce, Haynes W. Sheppard
Journal: Annals of Internal Medicine (1990)

Letters and Corrections15 May 1990Median Incubation Time for Human Immunodeficiency Virus (HIV)Warren Winkelstein Jr, MD, MPH, Rachel A. Royce, MPH, Haynes W. Sheppard, PhDWarren Winkelstein Jr, MD, MPHSearch for more papers by this author, Rachel A. Royce, MPHSearch for more papers by this author, Haynes W. Sheppard, PhDSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-112-10-797 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the Editor: Wolinsky and colleagues (1) conclude that the median time from human immunodeficiency virus type 1 (HIV-1) infection to seroconversion is 18 months, basing their calculation on their assertion that 20 of 24 men were positive for HIV-1-associated DNA 6 or more months before seroconversion. This report is the second from the Multicenter AIDS Cohort Study (MACS) to suggest prolonged latency (2); however, two independent cohort studies could not replicate the first findings (3, 4).We estimate that 100 seroconverters observed in the MACS (5) may have been eligible for Wolinsky and colleagues' study. Because selection criteria are...References1. WolinskyRinaldoKwok SCS. Human immunodeficiency virus type 1 (HIV-1) infection a median of 18 months before a diagnostic Western blot: evidence from a cohort of homosexual men. Ann Intern Med 1989;111:961-72. LinkGoogle Scholar2. ImagawaLeeWolinsky DMS. Human immunodeficiency virus type 1 infection in homosexual men who remain seronegative for prolonged periods. N Engl J Med. 1989;320:1458-62. CrossrefMedlineGoogle Scholar3. HorsburghOuHolmberg CCS. Human immunodeficiency type 1 infection in homosexual men who remain seronegative for prolonged periods [Letter]. N Engl J Med. 1989;321:1679-80. Google Scholar4. PanRoyceWinkelsteinLevy LRWJ. Human immunodeficiency virus type 1 infection in homosexual men who remain seronegative for prolonged periods [Letter]. N Engl J Med. 1989;321:1680. Google Scholar5. MuñozWangBass AMS. Acquired immunodeficiency syndrome (AIDS)-free time after human immunodeficiency virus type 1 (HIV-1) seroconversion in homosexual men. Am J Epidemiol. 1989;130:530-9. CrossrefMedlineGoogle Scholar1. WolinskyRinaldoKwok SCS. Human immunodeficiency virus type 1 (HIV-1) infection a median of 18 months before a diagnostic Western blot: evidence from a cohort of homosexual men. Ann Intern Med. 1990;111:961-72. LinkGoogle Scholar2. RankiValleKrohn ASM. Long latency precedes overt seroconversion in sexually transmitted human immunodeficiency virus infection. Lancet. 1987;2:589-93. CrossrefMedlineGoogle Scholar3. HorsburghOuJason CCJ. Duration of human immunodeficiency virus infection before detection of antibody. Lancet. 1989; 2:637-40. CrossrefMedlineGoogle Scholar4. YamamotoSpargerHo JEE. Pathogenesis of experimentally induced feline infection in cats. Am J Vet Res. 1988;49:1246-62. MedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: Warren WinkelsteinJr, MD, MPH; Rachel A. Royce, MPH; Haynes W. Sheppard, PhD PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byBiased Sampling of CohortsBiased Sampling of Cohorts 15 May 1990Volume 112, Issue 10Page: 797-798KeywordsAIDSCohort studiesDNAHIVHIV-1 ePublished: 1 December 2008 Issue Published: 15 May 1990 PDF downloadLoading ...