LÖFFLER'S SYNDROME FOLLOWING USE OF A VAGINAL CREAM
Authors: J F KLINGHOFFER
Journal: Annals of Internal Medicine (1954)

Case Reports1 February 1954LÖFFLER'S SYNDROME FOLLOWING USE OF A VAGINAL CREAMJUNE F. KLINGHOFFER, M.D.JUNE F. KLINGHOFFER, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-40-2-343 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptEvidence indicating that Löffler's syndrome is a manifestation of an allergic reaction in the lung tissue is steadily accumulating. From the time of its original description by Löffler1 in 1932, this syndrome of transitory pulmonary infiltrations associated with blood eosinophilia received much attention in European countries; it has been only in the past five years that American medical literature has reflected an equal degree of interest.Löffler and his co-workers2reproduced the syndrome in the guinea pig by the administration of ascaris eggs, and early reports stressed the relationship of this syndrome to parasitic infestation,3, 4, 5, 6, 7especially...Bibliography1. Löffler W: Zur differential Diagnose der Lungeninfiltrierungen, Frühinfiltrate unter besonder Berücksichtigung der Rückbildungszeiten, Beitr. z. Klin. Tuberk. 79: 338, 1932. CrossrefGoogle Scholar2. LöfflerEssellierMacedo WAFME: Zur Pathogenese und Ätiologie der flüchtigen Lunginfiltrate mit Bluteosinophilie (Löfflersches Syndrom), Helvet. med. acta 15: 223, 1948. MedlineGoogle Scholar3. Miller H: Transitory lung infiltrations accompanied by eosinophilia; report of a case, New England J. Med. 232: 7, 1945. CrossrefGoogle Scholar4. Cartwright GE: An unusual case of Clonorchiasis with marked eosinophilia and pulmonary infiltrations, Am. J. Med. 6: 259, 1949. CrossrefMedlineGoogle Scholar5. NemirHeymanGorvoyErvin RAJE: Pulmonary infiltrations and blood eosinophilia in children (Loeffler's syndrome), J. Pediat. 37: 819, 1950. CrossrefMedlineGoogle Scholar6. HoffHicks AHM: Transient pulmonary infiltrations; case with eosinophilia (Loeffler's syndrome) associated with amoebiasis, Am. Rev. Tuberc. 45: 194, 1942. Google Scholar7. Slowly JF: Löffler syndrome; transient successive pulmonary infiltration associated with trichiniasis; case, Ann. Int. Med. 21: 130, 1944. LinkGoogle Scholar8. HerbutKinsey PAFR: Transitory pulmonary infiltrations (Loeffler's syndrome) in rabbits, Arch. Path. 41: 489, 1946. Google Scholar9. JahielJahiel RR: Local organ hypersensitivity to autogenous antigens; experimental production of pneumonitis, J. Allergy 21: 102, 1950. CrossrefMedlineGoogle Scholar10. EngelElsomIngelfinger DKAFJ: Eosinophilia and pneumonitis in chronic brucellosis: a report of two cases, Ann. Int. Med. 16: 995, 1942. LinkGoogle Scholar11. Alpher IM: Loeffler's syndrome; report of two cases, one with recurrent features, and one associated with hay fever, J. Allergy 18: 39, 1947. CrossrefMedlineGoogle Scholar12. Tocker AM: Transitory pulmonary infiltrations (Loeffler's syndrome) with case report, J. Allergy 20: 211, 1949. CrossrefMedlineGoogle Scholar13. EllisMcKinlay RVCA: Allergic pneumonia, J. Lab. and Clin. Med. 26: 1427, 1941. Google Scholar14. Harkavy J: Cardiovascular allergy due to penicillin, sulfadiazine, and bacterial sensitization, J. Allergy 23: 104, 1952. CrossrefMedlineGoogle Scholar15. WarringHowlett FCKS: Allergic reactions to para-aminosalicylic acid; report of seven cases, including one case of Löffler's syndrome, Am. Rev. Tuberc. 65: 235, 1952. MedlineGoogle Scholar16. FalkNewcomer MSVD: Loeffler's syndrome, J.A.M.A. 141: 21, 1949. CrossrefMedlineGoogle Scholar17. ReichlinLovelessKane SMHEG: Loeffler's syndrome following penicillin therapy, Ann. Int. Med. 38: 113, 1953. LinkGoogle Scholar18. Harkavy J: Vascular allergy; pathogenesis of bronchial asthma with recurrent pulmonary infiltrations and eosinophilic polyserositis, Arch. Int. Med. 67: 709, 1941. CrossrefGoogle Scholar19. Harkavy J: Vascular allergy, J. Allergy 14: 507, 1943. CrossrefGoogle Scholar20. EhrlichRomanoff JA: Allergic granuloma of the lung, Arch. Int. Med. 87: 259, 1951. CrossrefGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Philadelphia, Pennsylvania*Received for publication July 6, 1953.This paper was presented in part at the May, 1952, meeting of the Laennec Society of Philadelphia. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited bySulfonamidesANTIBACTERIAL DRUGSGLUCOCORTICOIDS AND DISEASE – MODIFYING ANTIRHEUMATIC DRUGSSulfonamidesDrug-Induced Hypersensitivity Reactions in the LungIatrogenic Thoracic Complications Induced by DrugsOther Antibacterial DrugsTransient Eosinophilic Pneumonia Secondary to Use of a Vaginal CreamWHAT IS A HOME?DRUG-INDUCED LUNG DISEASEDrug-induced lung diseaseAllgemeine allergische Reaktionen (eosinophiles Infiltrat)Radiological manifestations of drug-induced diseaseAllergic Pulmonary Complications During Treatment with NitrofurantoinAscaris pneumoniaFuradantin AnaphylaxisPulmonary infiltrates, pericarditis and eosinophiliaRecurrent Pulmonary Infiltration and Pleural Effusion Due to Nitrofurantoin SensitivityLÖFFLER'S SYNDROME: REPORT OF A CASE ASSOCIATED WITH ADMINISTRATION OF MEPHENESIN CARBAMATE (TOLSERAM)*THEODORE RODMAN, M.D., WILLIAM FRAIMOW, M.D., RALPH M. MYERSON, M.D., F.A.C.P.Die eosinophilen LungeninfiltrateSulfonamideSulfonamide 1 February 1954Volume 40, Issue 2Page: 343-350KeywordsAllergy and immunologyBloodEosinophiliaGuinea pigsLungsPreventive medicine ePublished: 1 December 2008 Issue Published: 1 February 1954 PDF downloadLoading ...