RENAL TUBULAR HYPERCHLOREMIC ACIDOSIS WITH BONE DISEASE: A CASE REPORT
Authors: H W JOHNSON
Journal: Annals of Internal Medicine (1961)

Case Reports1 June 1961RENAL TUBULAR HYPERCHLOREMIC ACIDOSIS WITH BONE DISEASE: A CASE REPORTHERBERT W. JOHNSON, M.D., F.A.C.P.HERBERT W. JOHNSON, M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-54-6-1273 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptRenal acidosis resulting from tubular insufficiency without glomerular insufficiency is a relatively uncommon entity.1-14 It is accompanied frequently by calcification and stone formation in the kidney and occasionally by osteomalacia. The relative roles of hypercalciuria, systemic acidosis, and parathyroid activity in the pathogenesis of these complications are not certain, although Albright and colleagues postulated that parathyroid hyperplasia develops secondary to the renal loss of calcium. The primary disturbance, however, is clearly a failure of the kidney to excrete acid in a normal manner.The excretion of acid and the conservation of base is one of the major functions of the...Bibliography1. AlbrightReifenstein FEC: The parathyroid glands and metabolic bone disease. The Williams and Wilkins Co., Baltimore, 1948, pp. 205-262. Google Scholar2. ButlerWilsonFarber AMJLS: Dehydration and acidosis with calcification at renal tubules. J. Pediat. 8: 489-499 (Apr.) 1936. CrossrefGoogle Scholar3. AlbrightConsolazioCoombsSulkowitchTalbott FWVFSHWJH: Metabolic studies and therapy in a case of nephrocalcinosis with rickets and dwarfism. Bull. Johns Hopkins Hosp. 66: 7-33 (Jan.) 1940. Google Scholar4. RuleGrollman CA: Osteonephropathy: a clinical consideration of "renal rickets." Ann. Intern. Med. 20: 63-74, 1944. LinkGoogle Scholar5. BainesBarclayCooke GHJAWT: Nephrocalcinosis associated with hyperchloraemia and low plasma bicarbonate. Quart. J. Med. 14: 113-123 (Apr.) 1945. Google Scholar6. AlbrightBurnettParsonReifensteinRoos FGHWECA: Osteomalacia and late rickets. Medicine 25: 399-479 (Dec.) 1946. CrossrefMedlineGoogle Scholar7. Greenspan EM: Hyperchloremic acidosis and nephrocalcinosis. Arch. Intern. Med. 83: 271-291, 1949. CrossrefGoogle Scholar8. CookeKleeman RCCR: Distal tubular dysfunction with renal calcification. Yale J. Biol. Med. 23: 199-206, 1950. MedlineGoogle Scholar9. PinesMudge KLGH: Renal tubular acidosis with osteomalacia. Amer. J. Med. 11: 302-311, 1951. CrossrefMedlineGoogle Scholar10. SmithSchreiner LHGE: Studies on renal hyperchloremic acidosis. J. Lab. Clin. Med 43: 347-358, 1954. MedlineGoogle Scholar11. FossPerryWood GLCBFJ: Renal tubular acidosis. Quart. J. Med. 25: 185-199, 1956. MedlineGoogle Scholar12. James JA: Renal tubular disease with nephrocalcinosis. Amer. J. Dis. Child. 91: 601-605, 1956. CrossrefGoogle Scholar13. WilanskySchneiderman DLC: Renal tubular acidosis with recurrent nephrolithiasis and nephrocalcinosis. New Engl. J. Med. 257: 399-402, 1957. CrossrefMedlineGoogle Scholar14. FrichRubiniMeroney PGMEWH: Recurrent nephrolithiasis associated with an unusual tubular defect and hyperchloremic acidosis. Amer. J. Med. 25: 590-599 (Oct.) 1958. CrossrefMedlineGoogle Scholar15. BrownCurrensMarchand MRJHJF: Muscular paralysis and electrocardiographic abnormalities resulting from potassium loss in chronic nephritis. J. A. M. A. 124: 545-549 (Feb. 26) 1944. CrossrefGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: St. Paul, Minnesota*Received for publication August 25, 1959.Requests for reprints should be addressed to Herbert W. Johnson, M.D., 755 Lowry Medical Arts Building, St. Paul 2, Minn. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited bySevere osteomalacia associated with renal tubular acidosis in Crohn's diseaseHormonale Osteopathien im ErwachsenenalterHormonale Osteopathien im ErwachsenenalterRenal Acid-Base Disorders: Pathogenesis and Management 1 June 1961Volume 54, Issue 6Page: 1273-1280KeywordsBoneCalciumExcretionKidney stonesLesionsParathyroidPathogenesisRenal diseasesRenal failure ePublished: 1 December 2008 Issue Published: 1 June 1961 PDF downloadLoading ...