Urate Crystals in Asymptomatic Metatarsophalangeal Joints
Authors: Abraham Weinberger, H. Ralph Schumacher, Carlos A. Agudelo
Journal: Annals of Internal Medicine (1979)

Brief Reports1 July 1979Urate Crystals in Asymptomatic Metatarsophalangeal JointsABRAHAM WEINBERGER, M.D., H. RALPH SCHUMACHER, M.D., CARLOS A. AGUDELO, M.D.ABRAHAM WEINBERGER, M.D.Search for more papers by this author, H. RALPH SCHUMACHER, M.D.Search for more papers by this author, CARLOS A. AGUDELO, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-91-1-56 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptPrecipitation of monosodium urate crystals within the joint appears to be a prerequisite for the development of acute gouty arthritis (1). These crystals can be found in the synovial fluid of patients with acute or chronic gouty arthritis. Further, urate crystals have been found in biopsies (2) or in aspirated fluids of asymptomatic but previously involved joints (AGUDELOCA, WEINBERGERA, SCHUMACHERHR, TURNERR, MOLINAJ. Unpublished observations.). Agudelo and Schumacher (3) have found synovial microtophi during first attacks of gout. Whether urate crystals can also be detected in the synovial fluid of asymptomatic joints not previously affected in...References1. MCCARTYHOLLANDER DJ. Identification of urate crystals in gouty synovial fluid. Ann Intern Med. 1961; 54:452-60. LinkGoogle Scholar2. ZEVELYFRENCHMIKKELSENDUFF HAWI. Synovial specimens obtained by knee joint punch biopsy: histologic study in joint diseases. Am J Med. 1956; 20:510-9. CrossrefMedlineGoogle Scholar3. AGUDELOSCHUMACHER CH. The synovitis of acute gouty arthritis: a light and electron microscopic study. Hum Pathol. 1973; 14:265-79. CrossrefGoogle Scholar4. GARROD A. A Treatise on Gout and Rheumatic Gout (Rheumatoid Arthritis). 3rd ed. London: Longmans, Green and Co., Ltd.; 1876. Google Scholar5. MCCARTY D. The gouty toe—a multifactorial condition. Ann Intern Med. 1977; 86:234-6. Editorial. LinkGoogle Scholar6. SCHUMACHER H. Pathogenesis of crystal induced synoyitis. Clin Rheum Dis. 1977; 3:105-31. CrossrefGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. 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HOFFMAN, M.D., H. RALPH SCHUMACHER, M.D., HERNANDO PAUL, M.D., VARGHESE CHERIAN, Ph.D., ROBERTA REED, Ph.D., ALLAN G. RAMSAY, M.D., WALTER A. FRANCK, M.D.Aspiration of the asymptomatic metatarsophalangeal joint in gout patients and hyperuricemic controlsDisorders of Purine and Pyrimidine Metabolism Basic and Clinical ConsiderationsExperimental modelsCrystal-Associated Arthropathies: What's New in Old Joints† 1 July 1979Volume 91, Issue 1Page: 56-57KeywordsArthritisBiopsyGoutSynovial fluidUric acid Issue Published: 1 July 1979 PDF downloadLoading ...