THE NEUROLOGIC MANIFESTATIONS OF THE ACUTE LEUKEMIAS: A CLINICAL STUDY
Authors: C E WELLS, R T SILVER
Journal: Annals of Internal Medicine (1957)

Article1 March 1957THE NEUROLOGIC MANIFESTATIONS OF THE ACUTE LEUKEMIAS: A CLINICAL STUDYCHARLES E. WELLS, M.D., RICHARD T. SILVER, M.D.CHARLES E. WELLS, M.D., RICHARD T. SILVER, M.D.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-46-3-439 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptINTRODUCTIONAlthough neurologic disorders are frequent in the acute leukemias, their clinical aspects generally have not been emphasized. Reports of nervous system manifestations in this disease have been published, but they have been either reviews of the literature1, 2, 3, 4 or based upon retrospective studies.3, 4 We have recently had an opportunity to observe the neurologic manifestations in a group of patients with acute leukemia. The purpose of the present communication is to direct attention to their frequency and course.METHODSThis report comprises observations made on 63 patients with proved acute leukemia admitted to the National Cancer Institute...Bibliography1. Forkner CE: Leukemia and allied disorders, 1938, The Macmillan Company, New York. CrossrefGoogle Scholar2. Rouquès L: Les complications nerveuses des leucémies, Ann. méd. 47: 152, 1946. Google Scholar3. SchwabWeiss RSS: The neurologic aspect of leukemia, Am. J. M. Sc. 189: 766, 1935. CrossrefGoogle Scholar4. Brandt S: Altérations leucémiques du système nerveux, Acta psychiat. et neurol. 20: 107, 1945. CrossrefGoogle Scholar5. Diamond IB: Leukemic changes in the brain: a report of fourteen cases, Arch. Neurol. and Psychiat. 32: 118, 1934. CrossrefGoogle Scholar6. LeidlerRussell FWO: The brain in leukemia, Arch. Path. 40: 14, 1945. Google Scholar7. LászlóoKalabayGaál JLM: Altérations cérébrales au cours de la leucémie, Acta morphol. 2: 145, 1952. Google Scholar8. Nordlander NB: Eosinophilic leukemia. Infiltration of the gasserian ganglion, Acta med. Scandinav. 139: 146, 1951. CrossrefMedlineGoogle Scholar9. Sansone G: Pathomorphosis of acute infantile leukaemia treated with modern therapeutic agents; "meningoleukaemia" and Frölich's obesity, Ann. pædiat. 183: 33, 1954. MedlineGoogle Scholar10. Jaffé RH: Morphology of the inflammatory defense reactions in leukemia, Arch. Path. 14: 177, 1932. Google Scholar11. HitzigSiebermann WH: Scheinbare Schädelnahtsprengung bei Leukamie, Helvet. paediat. acta 10: 590, 1955. MedlineGoogle Scholar12. MurphyBrody JPBS: Nerve root infiltration in myelogenous leukemia, J. A. M. A. 115: 1544, 1940. CrossrefGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Bethesda, Maryland*Received for publication October 2, 1956.From the Medical Neurology Branch, National Institute of Neurological Diseases and Blindness, National Institutes of Health, Public Health Service, U. S. Department of Health, Education, and Welfare, and the Leukemia Section, General Medicine Branch, National Cancer Institute, National Institutes of Health.Requests for reprints should be addressed to Charles E. Wells, M.D., in care of Miss Joyce Jenkins, Clinical Center, Room 5S242, National Institutes of Health, Bethesda, Maryland . 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