THE SOLUBILITY OF ACETYLSULFAPYRIDINE AND ACETYLSULFATHIAZOLE IN THE URINE
Authors: Arthur C. Curtis, Sidney S. Sobin
Journal: Annals of Internal Medicine (1941)

Article1 November 1941THE SOLUBILITY OF ACETYLSULFAPYRIDINE AND ACETYLSULFATHIAZOLE IN THE URINEARTHUR C. CURTIS, M.D., F.A.C.P., SIDNEY S. SOBIN, PH.D.ARTHUR C. CURTIS, M.D., F.A.C.P.Search for more papers by this author, SIDNEY S. SOBIN, PH.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-15-5-884 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptShortly after the introduction of sulfapyridine into clinical medicine, hematuria was described as one of the common and dangerous complications of this type of therapy. Acetylsulfapyridine was demonstrated as the excretory form of the drug,1, 2, 3 and the relationship between crystals of acetylsulfapyridine in the urine and hematuria was quickly recognized.4, 5, 6, 7, 8This work was begun to record the solubility characteristics of acetylsulfapyridine and to determine the type and the amount of urine necessary to effect complete solution of this material. Our method was as follows: a portion of urine was concentrated to a specific gravity...Bibliography1. MARSHALLBRATTONLITCHFIELD EKACJT: The toxicity and absorption of 2-sulfanilamidopyridine and its soluble sodium salt, Science, 1938, lxxxviii, 595. Google Scholar2. RATISHBULLOWAAMESSCUDI HDJGJBJF: Urinary excretion product of sulfanilyl-2-aminopyridine, Jr. Biol. Chem., 1939, cxxviii, 279. CrossrefGoogle Scholar3. BAINESWEIN EJR: The absorption and excretion of 2-sulfanilyl-amino-pyridine, Quart. Jr. and Year Book of Pharmacy, 1939, xii, 4. Google Scholar4. SOUTHWORTHCOOKE HC: Hematuria, abdominal pain, and nitrogen retention associated with sulfapyridine, Jr. Am. Med. Assoc., 1939, cxii, 1820. Google Scholar5. LAWRENCE EA: Recent advances in the treatment of pneumonia, Internat. Rev. Recent Adv. in Med., 1939, iii, 48. Google Scholar6. SNAPPERLIUCHUNGYUSUN ISHHLTFHM: Hematuria, renal colic and acetylsulfapyridine stone formation, Chinese Med. Jr., 1939, lvi, 1. Google Scholar7. GRAHAMWARNERDAUPHINEEDICKSON DWPJARC: The treatment of pneumococcal pneumonia with dagenan, Canad. Med. Assoc. Jr., 1939, xl, 325. Google Scholar8. LONGWOOD PHWB: Observations upon the experimental and clinical use of sulfapyridine. II. The treatment of pneumococcal pneumonia with sulfapyridine, ANN. INT. MED., 1939, xiii, 487. Google Scholar9. BRATTONMARSHALL ACEK: New coupling component for sulfanilamide determination, Jr. Biol. Chem., 1939, cxxviii, 537. CrossrefGoogle Scholar10. SCHMIDTHUGHES LHHB: Absorption and excretion of sulfanilamidopyridine, Proc. Soc. Exper. Biol. and Med., 1939, xl, 409. CrossrefGoogle Scholar11. STOKINGER JE: Absorption, acetylation, and excretion of 2-sulfanilamidopyridine, Proc. Soc. Exper. Biol. and Med., 1930, xl, 61. Google Scholar12. SCUDIRATISHBULLOWA JFHDJG: Increased glycuronate excretion following administration of sulfapyridine, Science, 1939, lxxxix, 516. CrossrefGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Ann Arbor, Michigan*Received for publication February 15, 1941.From the Department of Internal Medicine, University of Michigan Medical School, Ann Arbor. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byRenal Complications of Sulfonamide TherapyComparative toxicities of sulfadiazine and sulfathiazole in childrenHydrogen Ion Concentration and the Solubility of Sulfonamides in Urine; The Relation to Renal Precipitation 1 November 1941Volume 15, Issue 5Page: 884-889KeywordsDrugsUrine ePublished: 1 December 2008 Issue Published: 1 November 1941 PDF downloadLoading ...