The Incidence of Elevated Hemoglobin A_2 Levels in the American Negro
Authors: MICHAEL A. GOLDSTEIN
Journal: Annals of Internal Medicine (1964)

Article1 January 1964The Incidence of Elevated Hemoglobin A2 Levels in the American NegroMICHAEL A. GOLDSTEIN, M.D., NONGNUCH PATPONGPANIJ, M.D., VIRGINIA MINNICH, M.S.MICHAEL A. GOLDSTEIN, M.D.Search for more papers by this author, NONGNUCH PATPONGPANIJ, M.D.Search for more papers by this author, VIRGINIA MINNICH, M.S.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-60-1-95 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptHemoglobin A2is present in a concentration of less than 3.3 per cent of the total hemoglobin in all normal adults (1). Elevation above this level is known to accompany the erythrocyte abnormalities seen in classical thalassemia trait (1, 2). Whereas thalassemia major has rarely been described in the American Negro, many cases of sickle cell thalassemia have been reported in this race (summarized by Dacie (3)). It seemed of interest, therefore, to screen a random population of Negroes for an exact estimate of the prevalence of elevated hemoglobin A2values. The results obtained revealed an increased amount of hemoglobin...References1. KUNKELWALLENIUS HGG: New hemoglobin in normal adult blood. Science 122: 288, 1955. CrossrefMedlineGoogle Scholar2. GERALDDIAMOND PSLK: The diagnosis of thalassemia trait by starch block electrophoresis of the hemoglobin. Blood 13: 61, 1958. CrossrefMedlineGoogle Scholar3. DACIE JV: The Hemolytic Anaemias Congenital and Acquired. Part I. The Congenital Anaemias. 2nd ed., Grune & Stratton, New York, 1960, p. 263. Google Scholar4. SINGERCHERNOFFSINGER KAIL: Studies on abnormal hemoglobins. I. Their demonstration in sickle cell anemia and other hematologic disorders by means of alkali denaturation. Blood 6: 413, 1951. CrossrefMedlineGoogle Scholar5. ROBINSONROBSONHARRISONZUELZER ARMAPWW: A new technique for differentiation of hemoglobin. J. Lab. Clin. 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Northwest. Med. 45: 23, 1946. MedlineGoogle Scholar17. FABERROTH HKBM: Mediterranean anemia (Cooley) in a Negro girl. J. Pediat. 28: 610, 1946. CrossrefMedlineGoogle Scholar18. SCOTTFERGUSONJENKINS RBADME: Thalassemia major (Mediterranean or Cooley's Anemia): report of two cases in Negro children. Amer. J. Dis. Child. 104: 106, 1962. CrossrefGoogle Scholar19. SHEPARDWEATHERALLCONLEY MKDJCL: Semi-quantitative estimation of the distribution of fetal hemoglobin in red cell populations. Bull. Hopkins Hosp. 110: 293, 1962. MedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: MICHAEL A. GOLDSTEIN, M.D.; NONGNUCH PATPONGPANIJ, M.D.; VIRGINIA MINNICH, M.S.Affiliations: St. Louis, MissouriFrom the Department of Medicine, Washington University School of Medicine, St. Louis, Missouri.This work was supported in part by United States Public Health grant H-22, Bethesda Maryland, and gifts given in memory of Bill Burns, Philipp Hunkel, Mark Edison, and Frederick A. Jostes.Requests for reprints should be addressed to Virginia Minnich, M.S., Department of Internal Medicine, Barnes Hospital, 600 South Kingshighway, St. Louis 10, Missouri. 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HERION, M.D.Normal and Abnormal Human HemoglobinsInherited disorders of hemoglobin synthesis and pregnancyThe ThalassemiasStudies on Thalassaemia-like Anaemias in Pregnant Immigrants in London*Frequency of Hemoglobinopathies in SarcoidosisSIGMUND R. GREENBERG, M.D., JEAN ATWATER, B.S., HAROLD L. ISRAEL, M.D., F.A.C.P. 1 January 1964Volume 60, Issue 1Page: 95-99KeywordsBeta-thalassemiaBurnsGeneticsHemoglobinMemoryPopulation geneticsPrevention, policy, and public healthRacial and ethnic issuesRisk managementThalassemia ePublished: 1 December 2008 Issue Published: 1 January 1964 PDF downloadLoading ...