OBSERVATIONS UPON THE EXPERIMENTAL USE OF SULFAPYRIDINE. I. THE RELATION OF STRAIN RESISTANCE TO THE CHEMOTHERAPEUTIC EFFECTS OF SULFAPYRIDINE IN EXPERIMENTAL PNEUMOCOCCAL INFECTIONS IN MICE
Authors: Perrin H. Long, Eleanor A. Bliss
Journal: Annals of Internal Medicine (1939)

Article1 August 1939OBSERVATIONS UPON THE EXPERIMENTAL USE OF SULFAPYRIDINE. I. THE RELATION OF STRAIN RESISTANCE TO THE CHEMOTHERAPEUTIC EFFECTS OF SULFAPYRIDINE IN EXPERIMENTAL PNEUMOCOCCAL INFECTIONS IN MICEPERRIN H. LONG, M.D., ELEANOR A. BLISS, Sc.D.PERRIN H. LONG, M.D.Search for more papers by this author, ELEANOR A. BLISS, Sc.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-13-2-232 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptIn theLancetof May 28, 1938, L. E. H. Whitby1reported that 2 (p-aminobenzenesulphonamido) pyridine (sulfapyridine) was "chemotherapeutically active in experimental infections in mice against pneumococci of types I, II, III, V, VII, VIII and especially against types I, VII and VIII." Whitby also stated in this paper that the drug appeared "to exert a definite action on the capsule of the pneumococcus." Within a very short time after this communication appeared, Evans and Gaisford2reported that they had treated with sulfapyridine 100 patients suffering from lobar pneumonia, and that in this group of patients the case fatality rate...Bibliography1. WHITBY LE: Chemotherapy of pneumococcal infections with 2(p-aminobenzenesulphonamido) pyridine, Lancet, 1938, i, 1210. CrossrefGoogle Scholar2. EVANSGAISFORD GMWF: Treatment of pneumonia with 2 (p-aminobenzenesulphonamido) pyridine, Lancet, 1938, ii, 14. CrossrefGoogle Scholar3. LONGBLISSFEINSTONE PHEAWH: The effects of sulfapyridine, sulfanilamide and related compounds in bacterial infections, Penn. Med. Jr., 1939, xlii, 483. Google Scholar4. COOPERGROSSLEWIS FBPM: Chemotherapeutic evaluation of sulfanilamide and 2 (sulfanilamide) -pyridine in Type II pneumococcal infections in mice and rats, Proc. Soc. Exper. Biol. and Med., 1939, xl, 37. CrossrefGoogle Scholar5. HILLESSCHMIDT CLH: Sulfanilamidepyridine (2 para-aminobenzenesulfonamidopyridine) in experimental infections with Type XXII pneumococcus, Proc. Soc. Exper. Biol. and Med., 1939, xl, 37. Google Scholar6. RAIZISSSEVERACMOETSCHCLEMENCE GWMJCLW: Comparative effects of sulfapyridine and sulfanilamide in Type II pneumococcic infections of mice, Proc. Soc. Exper. Biol. and Med., 1939, xl, 434. CrossrefGoogle Scholar7. SCHMIDTHILLES LHC: Further studies on therapeutic properties of sulfapyridine in experimental pneumococcus infections, Proc. Soc. Exper. Biol. and Med., 1939, xl, 611. CrossrefGoogle Scholar8. BLISSFEINSTONEGARRETTLONG EAWHAWPH: Sulfapyridine and sulfanilamide in experimental pneumococcal, meningococcal, Welch bacillary and Friedländer's bacillary infections in mice, Proc. Soc. Exper. Biol. and Med., 1939, xl, 619. CrossrefGoogle Scholar9. GREEYMACLARENLUCAS PHDBCC: Comparative chemotherapy in experimental pneumococcal infections, Canad. Med. Jr., 1939, xl, 319. Google Scholar10. MACLEANROGERSFLEMING IHKBA: M. & B. 693 and pneumococci, Lancet, 1939, i, 562. CrossrefGoogle Scholar11. MACLEODDADDI CMG: A "sulfapyridine-fast" strain of pneumococcus Type I, Proc. Soc. Exper. Biol. and Med., 1939, xli, 69. CrossrefGoogle Scholar12. MACLEOD CM: Metabolism of "sulfapyridine-fast" and parent strains of pneumococcus Type I, Proc. Soc. Exper. Biol. and Med., 1939, xli, 215. CrossrefGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: PERRIN H. LONG, M.D.; ELEANOR A. BLISS, Sc.D.Affiliations: Baltimore, Maryland*Received for publication July 1, 1939.This investigation was supported by a grant from The Chemical Foundation, Inc., of New York City.From the Biological Division, The Department of Medicine, The Johns Hopkins University, Baltimore, Maryland. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byDie Chemotherapie der durch Virusarten hervorgerufenen InfektionskrankheitenProceedingsTenth Annual Meeting of the American Academy of PediatricsTHE CHRISTMAS GIFTDETOXICATION OF SULPHONAMIDES"WITHOUT REFERRING TO THE ETHICAL SIDE " 1 August 1939Volume 13, Issue 2 Page: 232-237 Keywords Drugs Pneumococcus Pneumonia ePublished: 1 December 2008 Issue Published: 1 August 1939 PDF downloadLoading ...