COMPARATIVE STUDIES ON THE IODINE ABSORPTION OF ANAYODIN, CHINIOFON, DIODOQUIN, AND VIOFORM IN MAN
Authors: A A KNIGHT, J MILLER
Journal: Annals of Internal Medicine (1949)

Article1 June 1949COMPARATIVE STUDIES ON THE IODINE ABSORPTION OF ANAYODIN, CHINIOFON, DIODOQUIN, AND VIOFORM IN MANALVA A. KNIGHT, M.D., F.A.C.P., JEANNE MILLER, B.S., M.S.ALVA A. KNIGHT, M.D., F.A.C.P.Search for more papers by this author, JEANNE MILLER, B.S., M.S.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-30-6-1180 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptDavid, Phatak, and Zener,1in 1943, published studies made on the toxicity and absorption of Iodochlorhydroxyquinoline (Vioform) and Diïodohydroxyquinoline (Diodoquin) in man. Their studies failed to include Iodoxyquinoline sulphonic acid (Chiniofon) also known as Anayodin or Yatren. Likewise, Diodoquin was not given in its recommended therapeutic dosage; therefore, the blood iodine levels and toxicity were not determined at therapeutic levels. Toxicity studies revealed both Vioform and Diodoquin to be relatively safe drugs since the recommended full therapeutic dosage in the thinnest individual is not over 8 mg. per kg. of Vioform and 30 mg. per kg. of Diodoquin. The lethal...Bibliography1. DAVIDPHATAKZENER NANMFB: Iodochlorhydroxyquinoline and diiodohydroxyquinoline; animal toxicity and absorption in man, Am. Jr. Trop. Med., 1944, xxiv, 29-33. CrossrefGoogle Scholar2. DAVIDJOHNSTONEREEDLEAKE NAHGACCD: Treatment of amebiasis with iodochlorhydroxyquinoline (vioform N.N.R.), Jr. Am. Med. Assoc., 1933, c, 1658-1661. CrossrefGoogle Scholar3. ANDERSONREED HHAC: Untoward effects of anti-amebic drugs, Am. Jr. Trop. Med., 1934, xiv, 269-281. CrossrefGoogle Scholar4. ANDERSONDAVIDKOCH HHNADA: Effects of halogenation of oxyquinoline on biological activity, Proc. Soc. Exper. Biol. and Med., 1931, xxviii, 484-485. CrossrefGoogle Scholar5. MATTHEWSCURTISBRODIE NLGMWR: Determination of iodine in biological materials, Indust. and Eng. Chem., Anal. Ed., 1938, x, 612-615. CrossrefGoogle Scholar6. LEIPERT T: Die Bestimmung kleinster Jodmengen in organischem Material, Biochem. Ztschr., 1933, cclxi, 436-443. Google Scholar7. SPECTORHAMILTON HTS: Microdetermination of iodine in biological materials with special reference to combustion of samples in Parr oxygen bomb, Jr. Biol. Chem., 1945, clxi, 127-135. CrossrefGoogle Scholar8. GROAK B: Permanganatoxydation, in der Jodmikromethodik, Biochem. Ztschr., 1934, cclxx, 291-296. Google Scholar9. Searle Pamphlet on Diodoquin, 1937. Google Scholar10. CRAIG CF: Medicinal prophylaxis of amebiasis, Am. Jr. Trop. Med., 1940, xx, 799-801. CrossrefGoogle Scholar11. MANSON-BAHR P: Some tropical diseases in general practice, Glasgow Med. Jr., 1946, xxvii, 123. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Chicago, Illinois*Read before the Twenty-eighth Annual Session of the American College of Physicians, Chicago, Illinois, April 30, 1947.From the Department of Internal Medicine of the Presbyterian Hospital of the city of Chicago, affiliated with the University of Illinois. Supported by a grant from the Otho S. A. Sprague Memorial Institute.Acknowledgment is made to Dr. William H. Welker of the Department of Biochemistry of the University of Illinois College of Medicine for the use of laboratory facilities. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byThe Chemotherapy of Tropical Diseases Part I. Protozoal InfectionsAntiprotozoicaToxicity of Halogenated Oxyquinolines in Dogs. A Clinical StudyToxicity of Halogenated Oxyquinolines in Dogs. A Clinical StudyToxicity of Halogenated Oxyquinolines in Dogs. A Clinical StudySERUM-LEVELS OF PROTEIN-BOUND IODINE AND THYROXINE AFTER A COURSE OF CLIOQUINOLChemotherapy of AmebiasisEYE SYMPTOMS IN ACRODERMATITIS ENTEROPATHICAThe Effect of Iodochlorohydroxyquinoline, Di-Iodohydroxyquinoline and Dichlorohydroxyquinal-Dine on the Thyroid Uptake of Radio-IodineProtozoenkrankheiten 1 June 1949Volume 30, Issue 6Page: 1180-1187KeywordsAdverse reactionsBiochemistryBloodHospital medicineResearch laboratoriesToxicity ePublished: 1 December 2008 Issue Published: 1 June 1949 PDF downloadLoading ...