tbuckley/cabot-search huggingface dataset:
Abstract 11915: Clinical Gadolinium-Free Magnetic Resonance Imaging With Magnetization Transfer Contrast Detects Cardiac Fibrosis With High Sensitivity and Specificity Compared to Late Gadolinium Enhanced Imaging
Authors: Tori A Stromp, Steve W Leung, Linyuan Jing, Brandon K Fornwalt, Vincent L Sorrell, Moriel H Vandsburger
Journal: Circulation (2014)

Intro: Cardiac fibrosis identified by late gadolinium enhanced (LGE) cardiac MRI (CMR) is prognostic of adverse cardiac events, but is contraindicated in high-risk patients with impaired renal function. The signal intensity of balanced steady state free precession (bSSFP) CMR images is weighted by magnetization transfer (MT) from extracellular matrix macromolecules as a function of flip angle. We hypothesized that changes in the MT ratio (MTR) from pairs of differentially MT-weighted bSSFP cine images can enable identification of cardiac fibrosis without gadolinium.

Methods: Patients (n=47) referred for CMR were imaged on a 1.5T Siemens Aera scanner (Erlanger, Germany). Pairs of differentially MT-weighted bSSFP images (excitation flip angles of 5° or 45°), native T1 maps and T2 maps were acquired in one mid-ventricular slice. LGE images and post-contrast T1 maps were acquired after injection of gadolinium-DTPA (0.2 mmol/kg) and gadolinium partition coefficient (GPC) was calculated. MTR maps were calculated as (S45-S5)/S5*100 (%), where Sflip_angle is the voxel signal intensity. A feature tracking algorithm was used to measure peak endocardial circumferential strain, systolic and diastolic strain rates. Voxels were classified as healthy or enhanced at LGE and applied to maps of MTR, native T1, T2, and GPC for each patient.

Results: In 22 patients with fibrosis MTR maps and LGE revealed similar enhancement patterns (Fig A, B). Mean MTR, native T1, T2, and GPC were higher and peak strain was reduced in fibrotic tissue (p<0.05 healthy v. fibrotic for all). While MTR (R = 0.82), T1 (R = 0.55), and T2 (R = 0.75) correlated with GPC, receiver operating characteristic analysis revealed higher area under the curve values for MTR (0.96) compared to native T1 (0.78), T2 (0.84), peak strain (0.66), systolic (0.64) and diastolic (0.65) strain rates (Fig C, p<0.05 MTR v. all).

Conclusion: MT-weighted bSSFP cine CMR identified cardiac fibrosis comparable to LGE but without gadolinium.

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Reducing Diabetes Deaths
Authors: Joan Stephenson
Journal: JAMA (2004)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Abstract P391: Clinically Significant Blood Pressure Reduction Among Participants of a Lifestyle intervention Improvement Program strongly associated with Reduced Systemic Inflammation in a High Risk Working Population
Authors: Henry Guzman, Maribeth Rouseff, Thinh Tran, Khurram Nasir, Josette Bou-Khalil, Joseph Mora, Sankalp Das, Doris Brown, Joann Santiago-Charles, Teresa C. Ochoa, Cynthia Gilliam, Virginia Lehn, Ehimen Aneni, Ebenezer Oni, Lara Robertson, Emir Veledar, Janisse Post, Beatriz Castillo
Journal: Circulation (2014)

Background: In this study we aim to assess the short term effects of clinically significant Blood Pressure (BP) reduction after a behavioral intervention on systemic inflammation, measured by elevated high sensitivity c-reactive protein (HSCRP), in a high cardiovascular disease (CVD) risk cohort. Methods: The study was conducted among 180 employees of Baptist Health South Florida who had 2 or more CVD risk factors such as obesity, diabetes, hypertension or elevated total cholesterol and was involved in a three-month workplace lifestyle intervention. The intervention focused on nutritional and physical activity modifications. At baseline and at 3 months follow-up, anthropometric, clinical, and laboratory measures were obtained. Significant BP reduction was defined as systolic blood pressure (SBP) reduction ≥ 10mmHg or diastolic blood pressure (DBP) reduction ≥ 5mmHg at 3 months of follow-up. A HSCRP &gt;3mg/L was considered elevated. Results: Over the 3-month study period the median SBP decline was 16mmHg (IQR 4 -23mmHg) while the median reduction in DBP was 10mmHg (IQR 6 -16mmHg). 87% (156 participants) experienced significant BP reduction. Among those without significant BP reduction, the prevalence of elevated HSCRP at baseline was 58% and at follow-up it was 75% (p = 0.125). However, among those who had significant BP reduction, there was significant reduction in the prevalence of elevated HSCRP from 66.7% to 57.1% (p&lt;0.001). In unadjusted conditional logistic regression analyses significant BP reduction was associated with 94% reduction in the risk of elevated HSCRP at follow-up. In a fully adjusted model, this association persisted. Conclusion: Clinically significant reduction in blood pressure over a short period in a high cardiovascular disease risk working population is independently associated with markedly diminished risk of elevate hs-CRP. Longer follow-up intervention studies are required to further understand if these effects are sustained.
THE IMPORTANCE OF ALLOWING TIME FOR "PHYSIOLOGICAL ADJUSTMENT" IN ESTABLISHING THE DIET IN DIABETES
Authors: R. R. Snowden
Journal: Annals of Internal Medicine (1940)

Article1 November 1940THE IMPORTANCE OF ALLOWING TIME FOR "PHYSIOLOGICAL ADJUSTMENT" IN ESTABLISHING THE DIET IN DIABETESR. R. SNOWDEN, M.D., F.A.C.P.R. R. SNOWDEN, M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-14-5-789 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe term "physiological adjustment," as here used, refers to the way in which the physiological processes respond to the demands of carbohydrate metabolism. In the normal individual this adjustment is so prompt and efficient that even widely varying amounts of glucose are utilized almost immediately; in fact it is difficult to break through a normal glucose tolerance. In the diabetic, on the other hand, physiological adjustment is sluggish and lacks quick mobility; therefore, it can become fully effective only when the demands upon it are reasonable, and are maintained unchanged day after day until adjustment has had time to complete... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Pittsburgh, Pennsylvania*Read at the Cleveland meeting of the American College of Physicians April 4, 1940. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 November 1940Volume 14, Issue 5Page: 789-794KeywordsCarbohydrate metabolismDietGlucoseGlucose tolerance ePublished: 1 December 2008 Issue Published: 1 November 1940 PDF downloadLoading ...
Erratum: Corrigendum: Ca2+ and calmodulin initiate all forms of endocytosis during depolarization at a nerve terminal
Authors: Xin-Sheng Wu, Benjamin D McNeil, Jianhua Xu, Junmei Fan, Lei Xue, Ernestina Melicoff, Roberto Adachi, Li Bai, Ling-Gang Wu
Journal: Nature Neuroscience (2010)
Book: Peer Review in Health Sciences
Authors: H. Maisonneuve
Journal: BMJ (2000)

Fiona Godlee, Tom Jefferson BMJ Books, £30, pp 286 ISBN 0 7279 1181 3 Rating: ![Graphic][1]</img>![Graphic][2]</img>![Graphic][3]</img> Why do we still use a system to select manuscripts for publication and grant applications that is biased and has many drawbacks? Because we have no alternative; we want a system that has an impact on academic careers even if its methodology is poor. Publishing everything without review is desirable to some but unacceptable to many. A middle solution is currently envisaged on the internet, where peer-reviewed articles could be followed by reviewers' criticisms, the authors' answers, and even readers' comments. Most of us would agree that we need a formal peer … [1]: /embed/inline-graphic-1.gif [2]: /embed/inline-graphic-2.gif [3]: /embed/inline-graphic-3.gif
HIV-associated granuloma annulare (HAGA): a report of six cases
Authors: E.J. O’Moore, R. Nandawni, S. Uthayakumar, A.T. Nayagam, C.R. Darley
Journal: British Journal of Dermatology (2000)

Journal Article HIV‐associated granuloma annulare (HAGA): a report of six cases Get access E.J. O'Moore, E.J. O'Moore Department of HIV/Genito‐Urinary Medicine and Department of Dermatology, Royal Sussex County Hospital, Eastern Road, Brighton, U.K. Search for other works by this author on: Oxford Academic Google Scholar R. Nandawni, R. Nandawni Department of HIV/Genito‐Urinary Medicine and Department of Dermatology, Royal Sussex County Hospital, Eastern Road, Brighton, U.K. Search for other works by this author on: Oxford Academic Google Scholar S. Uthayakumar, S. Uthayakumar Department of HIV/Genito‐Urinary Medicine and Department of Dermatology, Royal Sussex County Hospital, Eastern Road, Brighton, U.K. Search for other works by this author on: Oxford Academic Google Scholar A.T. Nayagam, A.T. Nayagam Department of HIV/Genito‐Urinary Medicine and Department of Dermatology, Royal Sussex County Hospital, Eastern Road, Brighton, U.K. Search for other works by this author on: Oxford Academic Google Scholar C.R. Darley C.R. Darley Department of HIV/Genito‐Urinary Medicine and Department of Dermatology, Royal Sussex County Hospital, Eastern Road, Brighton, U.K. Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 142, Issue 5, 1 May 2000, Pages 1054–1056, https://doi.org/10.1046/j.1365-2133.2000.03501.x Published: 01 May 2000
Update of the International Banff Schema for liver allograft rejection: Working recommendations for the histopathologic staging and reporting of chronic rejection
Authors: Anthony Demetris, David Adams, Chris Bellamy, Karin Blakolmer, Andrew Clouston, Amar Paul Dhillon, John Fung, Annette Gouw, Bengt Gustafsson, Hironori Haga, David Harrison, John Hart, Stefan Hubscher, Ron Jaffe, Urmila Khettry, Charles Lassman, Klaus Lewin, Olivia Martinez, Yuichi Nakazawa, Desley Neil, Orit Pappo, Maria Parizhskaya, Parmjeet Randhawa, Susanne Rasoul-Rockenschaub, Finn Reinholt, Michel Reynes, Marie Robert, Athanassios Tsamandas, Ian Wanless, Russell Wiesner, Annika Wernerson, Fritz Wrba, Judy Wyatt, Hirohiko Yamabe
Journal: Hepatology (2000)
Abstract 137: PAK1 modulates a PPARγ/NF-κB cascade in intestinal inflammation
Authors: Kyle Dammann, Vineeta Khare, Michaela Lang, Thierry Claudel, Felix Harpain, Nicolas Granofszky, Rayko Evstatiev, Jonathan M. Williams, D. Mark Pritchard, Alastair Watson, Christoph Gasche
Journal: Cancer Research (2015)

Abstract Background &amp; Aims: P21-activated kinases (PAKs) are multifunctional effectors of Rho GTPases with both kinase and scaffolding activity. Here, we investigated the effects of inflammation on PAK1 signaling in inflammatory bowel diseases (IBD) including Crohn's disease (CD), ulcerative colitis (UC), and its role in colitis-associated carcinogenesis (CAC). Methods: PAK1 and p-PAK1 (Thr423) were assessed by immunohistochemistry (IHC), immunofluorescence, and Western blot. C57BL6/J wildtype mice were treated with a single i.p. TNFα injection. Small intestinal organoids from these mice and from PAK1-KO mice were cultured with TNFα. NF-κB and PPARγ were analyzed upon PAK1 overexpression and silencing. All data are mean±SD. Results: IHC revealed PAK1 expression increased from 2.8±1.6 in normal mucosa to 5.2±1.4 in CD, 6.0±1.7 in UC, and 8.8±1.0 in CAC. In UC, PAK1 activation increased at the luminal intestinal epithelial surface from 1.3±1.4 to 5.0±2.3. In primary colon epithelial cells, PAK1 was phosphorylated upon treatment with IFNγ, IL-1β, and TNFα. In vivo, mice administered with TNFα showed increased p-PAK1 from 4.3±1.0 to 9.9±0.1 in intestinal villi, which co-localized with NF-κB activation. Indeed, p65 nuclear translocation downstream of TNFα was strongly inhibited in PAK1-KO small intestinal organoids. PAK1 overexpression induced a PAK1-p65 interaction as visualized by co-immunoprecipitation, nuclear p65 translocation, and increased NF-κB transactivation four fold, all of which were impeded upon kinase-dead PAK1. Also PAK1 overexpression downregulated PPARγ mRNA levels from 1 to 0.4±0.1 and mesalamine recovered PPARγ to 0.8±0.04 through PAK1 inhibition. On the other hand PAK1 silencing inhibited NF-κB transactivation from 1 to 0.1±0.02, which was recovered upon the PPARγ antagonist BADGE to 0.5±0.1. Conclusions: Altogether these data demonstrate that PAK1 overexpression and activation in IBD and CAC promote NF-κB activity via suppression of PPARγ in intestinal epithelial cells. Citation Format: Kyle Dammann, Vineeta Khare, Michaela Lang, Thierry Claudel, Felix Harpain, Nicolas Granofszky, Rayko Evstatiev, Jonathan M. Williams, D. Mark Pritchard, Alastair Watson, Christoph Gasche. PAK1 modulates a PPARγ/NF-κB cascade in intestinal inflammation. [abstract]. In: Proceedings of the 106th Annual Meeting of the American Association for Cancer Research; 2015 Apr 18-22; Philadelphia, PA. Philadelphia (PA): AACR; Cancer Res 2015;75(15 Suppl):Abstract nr 137. doi:10.1158/1538-7445.AM2015-137
DINITROPHENOL AND RAPIDLY DEVELOPING CATARACTS
Authors: W. W. Boardman
Journal: Annals of Internal Medicine (1935)

Case Reports1 August 1935DINITROPHENOL AND RAPIDLY DEVELOPING CATARACTSW. W. BOARDMAN, M.D., F.A.C.P.W. W. BOARDMAN, M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-9-2-195 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptChronic obesity decreases efficiency and shortens life expectancy, especially through the increased incidence of cardiovascular disease and diabetes. The control of chronic obesity is therefore a definite and important problem in preventive medicine. Much has been written regarding the cause or causes of chronic obesity but, in the final analysis, obesity results from an excess of energy intake over the energy demands of the body. The control of obesity must lie in a reversal of this relationship with the creation of a deficit on the side of the intake as compared with the expenditure of energy.To obtain this result,... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: San Francisco, California*Received for publication June 24, 1935. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byZur Frage der Erzeugung der Dinitrophenolkatarakt im Tierversuch 1 August 1935Volume 9, Issue 2Page: 195-197KeywordsCardiovascular diseasesCataractsLife expectancyObesityPreventive medicine ePublished: 1 December 2008 Issue Published: 1 August 1935 PDF downloadLoading ...
An inflammatory breast carcinoma signature is associated with reduced relapse free survival in patients with non-inflammatory breast cancer.
Authors: Steven Van Laere, Ilse Van der Auwera, Gert Van den Eynden, Xuan Trinh, Hilde Elst, Peter van Dam, Eric Van Marck, Luc Dirix, Peter Vermeulen
Journal: Cancer Research (2008)

4099    Introduction.  Inflammatory Breast Cancer (IBC) is an aggressive form of breast cancer associated with poor survival. We hypothesize that an expression profile characteristic for IBC might be related to tumour aggressiveness and might be able to stratify nIBC patients with respect to prognosis.   Methods.  RNA was extracted from 19 IBC samples and 40 nIBC samples and hybridized onto Affymetrix chips. A gene signature predictive of IBC was identified and applied onto publicly available gene expression data from 1157 nIBC samples (7 data sets) with survival data of 881 nIBC samples (4 data sets). Samples were classified as IBC-like or nIBC-like. Relapse free survival (RFS) was compared by the Kaplan-Meier method for each dataset. In addition, we classified the same 1157 nIBC samples according to several other signatures with prognostic relevance, including the Cell-of-Origin Subtypes, the Wound Healing Response (WHR) signature, the Genomic Grade Index (GGI), the Fibroblastic Neoplasm Signature (FNS) and the Invasiveness Gene Signature (IGS). We compared these classifications with the classification according to the IBC signature. Cox regression analysis was performed to identify the most predictive signature with respect to RFS.   Results.  Kaplan-Meier analysis revealed a significant difference between nIBC breast tumours classified as IBC-like and nIBC-like with respect to RFS in all 4 data sets. Patients with an IBC-like phenotype demonstrate a shorter RFS interval. Classification according to the IBC signature is significantly associated with classification according to the cell-of-origin subtypes (p Discussion.  Our data demonstrate that nIBC breast tumours having an “IBC-like” phenotype have a significantly reduced RFS interval. This suggests that IBC and nIBC tumours demonstrate the same phenotypic traits with respect to aggressive tumour cell behavior. Despite the fact that the tumour/stroma ratio differs between IBC and nIBC and that IBC is generally of high grade, gene signatures only related to activated tumour stroma and tumour grade still add valuable information regarding patient survival. This suggests that the IBC signature represents a different aspect of aggressive tumour behavior, such as augmented tumour cell motility.
<i>Staphylococcus aureus</i> invades the epithelium in nasal polyposis and induces IL‐6 in nasal epithelial cells <i>in vitro</i>
Authors: F. Sachse, K. Becker, C. Von Eiff, D. Metze, C. Rudack
Journal: Allergy (2010)

To cite this article: Sachse F, Becker K, von Eiff C, Metze D, Rudack C. Staphylococcus aureus invades the epithelium in nasal polyposis and induces IL‐6 in nasal epithelial cells in vitro . Allergy 2010; 65 : 1430–1437. Abstract Background: Staphylococcus aureus has been associated with chronic rhinosinusitis with nasal polyps (CRSwNP) pathogenesis but its role is still controversially discussed. Here, we demonstrate S. aureus detection in the mucosa of CRSwNP. In addition, intracellular residency of S. aureus in nasal polyp epithelial cells (NPECs) and its capability to induce TH‐2 cytokines were analyzed in vitro . Methods: Staphylococcus aureus detection in CRSwNP ( n = 25), CRS without polyps (CRSsNP, n = 5), and turbinate mucosa (TM, n = 10) was performed by peptide nucleic acid‐fluorescence in situ hybridization (PNA‐FISH) and microbial cultivation from tissue biopsies. Intracellular residency was examined by intracellular persistence assay and electron microscopy. IL‐6 and IL‐13 responses to S. aureus infection and supernatants were quantified by ELISA. Results: Peptide nucleic acid‐fluorescence in situ hybridization positive bacterial cells were significantly increased in the epithelium of CRSwNP (17/25) compared to CRSsNP (0/5) and TM (1/10). Good concordance of PNA‐FISH results and S. aureus cultivation was found applying Cohen’s κ for CRSwNP (κ = 0.841) and TM (κ = 1.0). Intracellular persistence assay with S. aureus strain Newman and its corresponding small‐colony variant mutant strain III33 demonstrated intracellular survival and replication of S. aureus within NPECs. Both S. aureus strains significantly induced IL‐6 but not IL‐13 in infected NPECs and in NPECs challenged with corresponding staphylococcal supernatants. Conclusion: Invasion of the epithelium by S. aureus was a phenomenon seen predominantly in CRSwNP. Regardless of an intra‐ or extracellular localization in the epithelium, S. aureus is capable to induce IL‐6 synthesis in vitro and thus may contribute to the TH‐2 cytokine pattern in CRSwNP.
Expression of CD38 and its participation in formation of endothelial dysfunction in patients with bronchial asthma
Authors: Ludmila Kaptyuk, Irina Demko, Angelina Kraposhina, Natalya Ryazanova, Olga Ischenko, Elena Sobko, Alla Salmina
Journal: European Respiratory Journal (2011)

In the article we studied the role of CD38/ADP-ribosilcyclase in formation of endothelial dysfunction in patients with bronchial asthma.  In the research we have been included patients with mild (1st group) and severe (2nd group) bronchial asthma. We found the increased expression of CD38 in peripheral blood lymphocytes in patients of both groups (in the 1st group 4 out of 300 cells, in the 2nd 6 out of 300 cells) in an exacerbation in comparison with the control group (2 out of 300 cells). Increase of level of expression CD38 promotes the realisation of the mechanism of interaction of the activated lymphocytes with the cells of endothelium expressing of non-substrated ligand CD38 – CD 31/sPECAM-1.  We note increase of sPECAM-1 in plasma of peripheral blood in the 2nd group to 7,19 ng/ml [6,8; 7,7] in comparison with results of the patients of the 1st group: 6,78 ng/ml [6,09; 8,35] (p=0,022525). We found the positive interrelation between the level of CD31 and the expression of CD38 (r=0,3; p
Myocardial Perfusion Reserve a Stronger Predictor of Survival Than LV Ejection Fraction After a PET Driven Revascularisation
Authors: Rene Tio, Hans L. Hillege, Clark J. Zeebregts, Johan de Sutter, Rudi A. Dierckx, Dirk-Jan van Veldhuisen, Felix Zijlstra, Riemer H. Slart
Journal: Circulation (2009)