DIATRIN, A NEW ANTIHISTAMINIC WITH MINIMAL SIDE REACTIONS
Authors: S MARTON
Journal: Annals of Internal Medicine (1950)

Article1 December 1950DIATRIN, A NEW ANTIHISTAMINIC WITH MINIMAL SIDE REACTIONSSAMUEL MARTON, M.D., F.A.C.A.SAMUEL MARTON, M.D., F.A.C.A.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-33-6-1444 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptAlmost every physician in his daily practice meets some variety of allergic manifestation which requires relief or palliation. Of late, the antihistaminic drugs have come into prominence because of their ability to alleviate this condition. Unfortunately, the unpleasant side reactions which frequently accompany their use sometimes necessitate their discontinuance. Investigations therefore continue for a more effective and less toxic antagonist to histamine which would demonstrate fewer side reactions.The writer had the opportunity to procure one of the newer antihistaminics, Diatrin Hydrochloride,†for investigation. It was felt that, to evaluate clinically its therapeutic effectiveness and possible side reactions, more accurate...Bibliography1. CombesZuckermanCanizares FCRO: Diatrin Hydrochloride; clinical and toxicologic studies of a new antihistaminic agent, J. Invest. Dermat. 13: 139, 1949. CrossrefMedlineGoogle Scholar2. DaleLaidlaw HHPP: The physiological action of B-iminazelylethylamine, J. Physiol. 41: 318, 1910. CrossrefMedlineGoogle Scholar3. StaubBovet AMD: Action de la thymoxyethyldiethylamine (929F.) et des ethers phenoliques sur le choc anaphylactique du cobaye, Compt. rend. Soc. de biol. 125: 818, 1937. Google Scholar4. Halpern BN: Etude experimentale des antihistaminiques de synthese: Essais de chimiotherapie des etats allergiques, J. de méd. de Lyon 23: 409, 1942; Les antihistaminiques de synthese: Essais de chimiotherapie des etats allergiques, Arch. internat. de pharmacodyn. et de theráp. 68: 339, 1942. Google Scholar5. BovetHorcloisWalthert DRF: Proprietes antihistaminiques de la N-p-methoxybenzyl-N-dimethylaminoethyl a aminopyridine, Compt. rend. Soc. de biol. 138: 99, 1944. Google Scholar6. Skouby AP: Effect of 2-N-phenyl-N-benzylaminomethyl-imidazoline in allergie diseases, Nord. med. 34: 1022, 1947. MedlineGoogle Scholar7. Feinberg SM: The antihistaminic drugs, Am. J. Med. 3: 560, 1947. CrossrefMedlineGoogle Scholar8. SlaterFrancis BJNF: Benadryl, a contributing cause of an accident, J. A. M. A. 132: 212, 1946. CrossrefMedlineGoogle Scholar9. BlantonOwens WBME: Granulocytopenia due probably to Pyribenzamine, J. A. M. A. 134: 454, 1947. CrossrefMedlineGoogle Scholar10. Borman MC: Danger with Benadryl of self medication and large dosages, J. A. M. A. 133: 394, 1947. CrossrefMedlineGoogle Scholar11. Weil HR: Unusual side effect from Benadryl, J. A. M. A. 133: 393, 1947. CrossrefMedlineGoogle Scholar12. GeigerRosenfeldHartman JSZDL: Unusual reaction following Benadryl administration, J. A. M. A. 133: 392, 1947. CrossrefMedlineGoogle Scholar13. Lockey SD: Benadryl; clinical evaluation based on 171 case studies, Ann. Allergy 5: 420, 1947. MedlineGoogle Scholar14. Arbesman CE: The pharmacology, physiology and clinical evaluation of the new antihistaminic drugs (Pyribenzamine and Benadryl), New York State J. Med. 47: 1775, 1947. MedlineGoogle Scholar15. Loveless MH: Therapeutic and side effects of Pyribenzamine and Benadryl, Am. J. Med. 3: 266, 1947. CrossrefGoogle Scholar16. Tuft L: The newer antihistaminic drugs in the treatment of allergic states, Am. Pract. 2: 1, 1947. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: *Received for publication December 23, 1948.†Diatrin Hydrochloride was supplied through the courtesy of William R. Warner & Co., Inc., New York, St. Louis. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 December 1950Volume 33, Issue 6Page: 1444-1449KeywordsDrugsHistamine ePublished: 1 December 2008 Issue Published: 1 December 1950 PDF downloadLoading ...