tbuckley/cabot-search huggingface dataset:
Neoplastic Transformation of Syrian Hamster Cells by Putative Epoxide Metabolites of Commercially Utilized Chloroalkenes&lt;xref ref-type="fn" rid="fn2"&gt;2&lt;/xref&gt;
Authors: J A DiPaolo, J Doniger
Journal: JNCI Journal of the National Cancer Institute (1982)

The transforming ability of six epoxides of structurally related chloroalkenes was determined with a quantitative Syrian hamster embryo cell model. The epoxides used were cis-1-chloropropene oxide (c-CPO), trans-1-chloropropene oxide (t-CPO), cis-1,3-dichloropropene oxide, trans-1,3-dichloropropene oxide, trichloroethylene oxide (TCEO), and tetrachloroethylene oxide (PCEO). All six epoxides induced morphologic transformation of Syrian hamster embryo cells and caused cell lethality as reflected in the reduced cloning efficiency; in all instances, transformation was observed with less than 25% toxicity. The potency of the various epoxides was influenced by the difference in stability of the compounds. The results with c-CPO, t-CPO, TCEO, and PCEO were consistent with a linear dose response. The transformation results reflect the carcinogenicity of the parental chloroalkenes tested thus far. Furthermore, if the epoxides are metabolic intermediates of the chloropropene parent chloropropenes, the epoxides are probably proximate carcinogens.
Does the Presence of Hepatitis Virus B &amp; C Influence the Evolution of Diffuse Large B-Cell Lymphomas?
Authors: J. Rubio-Martínez, F. Franco, E. Almagro-Casado, D. Pérez-Callejo, M. Palka, A. Gonzaga, R. Núñez, A.C. Sanchez Ruiz, M. Méndez García, C. Maximiano, V. Calvo, B. Cantos, M. Provencio Pulla
Journal: Annals of Oncology (2014)
Sodium chloride inhibits the suppressive function of FOXP3+ regulatory T cells
Authors: Amanda L. Hernandez, Alexandra Kitz, Chuan Wu, Daniel E. Lowther, Donald M. Rodriguez, Nalini Vudattu, Songyan Deng, Kevan C. Herold, Vijay K. Kuchroo, Markus Kleinewietfeld, David A. Hafler
Journal: Journal of Clinical Investigation (2015)

FOXP3+ Tregs are central for the maintenance of self-tolerance and can be defective in autoimmunity. In multiple sclerosis and type-1 diabetes, dysfunctional self-tolerance is partially mediated by a population of IFNγ-secreting Tregs. It was previously reported that increased NaCl concentrations promote the induction of proinflammatory Th17 cells and that high-salt diets exacerbate experimental models of autoimmunity. Here, we have shown that increasing NaCl, either in vitro or in murine models via diet, markedly impairs Treg function. NaCl increased IFNγ secretion in Tregs, and reducing IFNγ — either by neutralization with anti-IFNγ antibodies or shRNA-mediated knockdown — restored suppressive activity in Tregs. The heightened IFNγ secretion and loss of Treg function were mediated by the serum/glucocorticoid-regulated kinase (SGK1). A high-salt diet also impaired human Treg function and was associated with the induction of IFNγ-secreting Tregs in a xenogeneic graft-versus-host disease model and in adoptive transfer models of experimental colitis. Our results demonstrate a putative role for an environmental factor that promotes autoimmunity by inducing proinflammatory responses in CD4 effector cells and Treg pathways.
The clinical expression of allergy in the skin
Authors: J Ring, M Thewes
Journal: Allergy (1999)

The cutaneous immune system has evolved to protect the organism from potential exogenous pathogens in a complex manner. Recent investigations of the special role of the skin in allergy have focused on the proinflammatory potential of various cells such as Langerhans' cells, keratinocytes, mast cells (MC), endothelial cells, and dermal fibroblasts. Furthermore, in processing and reacting to antigens, infiltrating inflammatory cells (lymphocytes; monocytes; macrophages; and eosinophil, neutrophil, and basophil granulocytes) play an important role both by cell-cell interactions with specific receptors on cell surfaces and via soluble mediators.
The Impact of FLT3-ITD and NPM1 Mutational Status on the Outcome of ATRA Therapy in Patients with Non-APL AML: Results of the UK MRC AML12 Trial
Authors: Rosemary Gale, Robert Hills, Claire Green, Yashma Patel, Amanda Gilkes, Michelle Lazenby, Keith Wheatley, David C. Linch, Alan Burnett
Journal: Blood (2008)
Abstract 14561: Elective Arterio-Venous Fistula Ligation Following Successful Renal Transplantation is Associated with Improvements in Cardiac and Vascular Structure and Function: A Cardiovascular MRI Study
Authors: Benjamin K Dundon, Matthew I Worthley, David K Torpey, Adam J Nelson, Rae Duncan, Dennis T Wong, Kym M Bannister, Randall J Faull, Stephen G Worthley
Journal: Circulation (2011)

Introduction: Renal transplantation provides an increasingly successful means of restoring renal excretory and metabolic function in end-stage renal failure, however cardiovascular risk amongst suc...
Differences in Sedentary Time and Physical Activity Between Female Patients With Fibromyalgia and Healthy Controls: The al‐Ándalus Project
Authors: Víctor Segura‐Jiménez, Inmaculada C. Álvarez‐Gallardo, Fernando Estévez‐López, Alberto Soriano‐Maldonado, Manuel Delgado‐Fernández, Francisco B. Ortega, Virginia A. Aparicio, Ana Carbonell‐Baeza, Jorge Mota, Pedro Silva, Jonatan R. Ruiz
Journal: Arthritis & Rheumatology (2015)

Objective To characterize the levels of objectively measured time spent in sedentary activities (sedentary time) and physical activities in female patients with fibromyalgia and compare them with the levels in age‐matched healthy control women. Methods The study comprised 413 female patients with fibromyalgia (mean ± SD age 51.9 ± 7.4 years) and 188 female control subjects (age 50.9 ± 7.5 years). Sedentary time, the amount of time spent engaged in physical activity, and step counts were measured using triaxial accelerometry. The amounts of time (minutes/day) during which the participants were engaged in sedentary behaviors as well as in physical activity of different intensities (light, moderate, and moderate‐to‐vigorous) and the step counts were calculated. Results The amount of time spent in sedentary behavior was longer in patients with fibromyalgia compared with controls (estimated mean ± SEM difference 39 ± 8 minutes/day; P &lt; 0.001). The patients with fibromyalgia spent less time than controls engaged in light physical activity (mean ± SEM difference −21 ± 7 minutes/day; P = 0.005), moderate physical activity (mean ± SEM difference −17 ± 3 minutes/day; P &lt; 0.001), and moderate‐to‐vigorous physical activity (mean ± SEM difference −19 ± 3 minutes/day; P &lt; 0.001). The patients with fibromyalgia took fewer steps/day compared with the control subjects (mean ± SEM difference −1,881 ± 262 steps/day; P &lt; 0.001). Only 20.6% of the patients with fibromyalgia and 46.3% of the control subjects fulfilled the recommendation for 150 minutes/week of moderate‐to‐vigorous physical activity in bouts of at least 10 minutes/bout (χ 2 = 41.8, P &lt; 0.001). Similarly, only 16.0% of the patients fulfilled the recommendation for ≥10,000 steps/day compared with 44.7% of the control subjects (χ 2 = 56.8, P &lt; 0.001). Both the patients and the control subjects were more active (physical activity of all intensities and numbers of steps) on weekdays than on weekend days (all P ≤ 0.001). Conclusion Female patients with fibromyalgia spent more time in sedentary behaviors and were less physically active than age‐matched controls. The low proportions of female patients with fibromyalgia and control subjects who met the physical activity and step count recommendations is worrisome.
Murine Leukemia Viruses: Induction of Macrophage Production of Granulocyte-Macrophage Colony-Stimulating Factor In Vitro23
Authors: Joel S. Greenberger, Lori M. Wroble, Mary Ann Sakakeeny
Journal: JNCI Journal of the National Cancer Institute (1980)

Journal Article Murine Leukemia Viruses: Induction of Macrophage Production of Granulocyte-Macrophage Colony-Stimulating Factor In Vitro Get access Joel S. Greenberger, Joel S. Greenberger 4Joint Center for Radiation Therapy, Department of Radiation Therapy, and Sidney Farber Cancer Institute, Harvard Medical School, 44 Binney St., Boston, Mass. 02115. Search for other works by this author on: Oxford Academic PubMed Google Scholar Lori M. Wroble, Lori M. Wroble 4Joint Center for Radiation Therapy, Department of Radiation Therapy, and Sidney Farber Cancer Institute, Harvard Medical School, 44 Binney St., Boston, Mass. 02115. Search for other works by this author on: Oxford Academic PubMed Google Scholar Mary Ann Sakakeeny Mary Ann Sakakeeny 4Joint Center for Radiation Therapy, Department of Radiation Therapy, and Sidney Farber Cancer Institute, Harvard Medical School, 44 Binney St., Boston, Mass. 02115. 5We are indebted to Ms. Paula J. Gans, Ms. Patricia B. Davisson, Ms. Diane Donahue, and Ms. Betty Webb for technical assistance; Dr. Stuart A. Aaronson and Dr. Samuel Hellman for helpful discussions; Dr. Richard Shadduck for parified L-cell colony-stimulating factor (CSF) and rabbit anti-L-cell CSF antiserum; and Dr. Richard Stanley for performing radioimmunoassays for L-cell CSF on pelleted virus preparations. Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 65, Issue 4, October 1980, Pages 841–852, https://doi.org/10.1093/jnci/65.4.841 Published: 01 October 1980 Article history Received: 06 March 1980 Accepted: 14 May 1980 Published: 01 October 1980
Research on Complementary/Alternative Medicine for Patients With Breast Cancer: A Review of the Biomedical Literature
Authors: Judith S. Jacobson, Sara B. Workman, Fredi Kronenberg
Journal: Journal of Clinical Oncology (2000)

PURPOSE: This article reviews English-language articles published in the biomedical literature from 1980 to 1997 that reported results of clinical research on complementary and alternative medical treatments (CAM) of interest to patients with breast cancer. METHODS: We searched 12 electronic databases and the bibliographies of the retrieved papers, review articles, and books on CAM and breast cancer. The retrieved articles were grouped by end point: breast cancer (eg, tumor size, survival), disease-related symptoms, side effects of treatment, and immune function. Within each end point, we organized the articles by modality and assessed study design, findings, and qualitative aspects. RESULTS: Of the more than 1,000 citations retrieved, 51 fit our criteria for review. Of the articles reviewed, 17 were randomized clinical trials; three of these were trials of cancer-directed interventions, two of which involved the same treatment (melatonin). Seven articles described observational studies, and the remainder were reports of phase I or II trials. Relatively few CAM modalities reportedly used by many breast cancer patients were mentioned in articles retrieved by this process. Most articles had shortcomings. CONCLUSION: Although many studies had encouraging results, none showed definitively that a CAM treatment altered disease progression in patients with breast cancer. Several modalities seemed to improve other outcomes (eg, acupuncture for nausea, pressure treatments for lymphedema). If CAM studies are well-founded, well-designed, and meticulously conducted, and their hypotheses, methods, and results are reported clearly and candidly, research in this controversial area should acquire credibility both in the scientific community and among advocates of unconventional medicine.
Long-term follow-up of ifosfamide renal toxicity in children treated for malignant mesenchymal tumors: an International Society of Pediatric Oncology report.
Authors: A Suarez, H McDowell, P Niaudet, E Comoy, F Flamant
Journal: Journal of Clinical Oncology (1991)

The renal function of 74 children with malignant mesenchymal tumors in complete remission and who have received the same ifosfamide chemotherapy protocol (International Society of Pediatric Oncology Malignant Mesenchymal Tumor Study 84 [SIOP MMT 84]) were studied 1 year after the completion of treatment. Total cumulative doses were 36 or 60 g/m2 of ifosfamide (six or 10 cycles of ifosfamide, vincristine, and dactinomycin [IVA]). None of them had received cisplatin chemotherapy. Ages ranged from 4 months to 17 years; 58 patients were males and 42 females. The most common primary tumor site was the head and neck. Renal function was investigated by measuring plasma and urinary electrolytes, glucosuria, proteinuria, aminoaciduria, urinary pH, osmolarity, creatinine clearance, phosphate tubular reabsorption, beta 2 microglobulinuria, and lysozymuria. Fifty-eight patients (78%) had normal renal tests, whereas 16 patients (22%) had renal abnormalities. Two subsets of patients were identified from this latter group: the first included four patients (5% of the total population) who developed major toxicity resulting in Fanconi's syndrome (TDFS); and the second group included five patients with elevated beta 2 microglobulinuria and low phosphate reabsorption. The remaining seven patients had isolated beta 2 microglobulinuria. Severe toxicity was correlated with the higher cumulative dose of 60 g/m2 of ifosfamide, a younger age (less than 2 1/2 years old), and a predominance of vesicoprostatic tumor involvement. This low percentage (5%) of TDFS must be evaluated with respect to the efficacy of ifosfamide in the treatment of mesenchymal tumors in children.
New Developments in the Management of Prostate Cancer
Authors: Philip W. Kantoff, James L. Mohler
Journal: Journal of the National Comprehensive Cancer Network (2013)

Rapid progress was recently made in the treatment of prostate cancer, especially metastatic castration-resistant prostate cancer. At the NCCN 18th Annual Conference, Dr. Philip W. Kantoff reviewed the data supporting the use of abiraterone acetate, enzalutamide, cabazitaxel, sipuleucel-T, and radium-223 (pending approval), and offered recommendations for their sequential use in different settings. Dr. James L. Mohler described factors that dictate who should receive treatment, when they should receive it, and how to treat in the setting of prostate-specific antigen elevation. He explained how better treatment decisions will result from individualized estimation of threat-to-life posed by prostate cancer, chance of cure by treatment, and treatment risks.
Usefulness of a myositis antibody immunoblot in diagnosis of connective tissue disease (CTD) related interstitial lung disease (ILD)
Authors: Jonathan Robson, Anna McHugh, Sinisa Savic, Paul Beirne
Journal: European Respiratory Journal (2014)

Background  Between 10% and 20% of ILD is associated with CTD, and ILD can be the first presentation of a CTD. Accurate ILD diagnosis requies a multidisciplinary (MDT) approach, and the inclusion of history, examination and autoimmune screens are necessary to seek out occult CTD. We have enhanced our autoimmune screen by adding a myositis antibody (Ab) immunoblot for ILD patients in whom CTD is suspected.  Aim  To evaluate whether a positive myositis immunoblot aids diagnosis or alters investigation or treatment of ILD when CTD is suspected.  Methods  A retrospective case review was carried out on patients presenting to the Leeds specialist ILD clinic with respiratory symptoms, who subsequently had a positive myositis immunoblot in the 15 months from May 2012.  Results  13 patients (9 male, 4 female, age range 16 – 79) were positive for 1 or more myositis Abs (6 PM-Scl-75, 5 Ro52, 3 PM-Scl-100, 1 each of PL-12, Ku, EJ and OJ proteins). 4 had myalgia but only 2 had an elevated serum creatine kinase. In 8/13 the standard autoimmune screen was negative but CTD was still suspected because of arthralgia (4), Raynauds (4), myalgia (2), sicca symptoms, rash, radiology or pathology findings (1 each). In these 8 patients the presence of myositis Abs had these effects: strengthened the MDT diagnosis of CTD-ILD (6/8), persuaded the MDT a surgical biopsy was no longer necessary (1/8), and changed the intended treatment (1/8 – from pirfenidone to cyclophosphamide).  Conclusion  In ILD patients suspected to have occult CTD, enhancing the autoimmune screen by adding a myositis Ab immunoblot does aid MDT diagnosis and can alter decisions regarding biopsy and treatment.
Abstract 3215: US Resources for Care of Adults with Congenital Heart Disease
Authors: William R Davidson, George H Warren, Amy Verstappen, Karen S Kuehl, Thomas P Graham
Journal: Circulation (2006)

We sought to determine the number, size, personnel, and resources of centers dedicated to the care of adult congenital heart disease (ACHD) patients (pts). 48 pediatric (P) and 174 adult (A) cardio...
Bronchial balloon occlusion in children with complex pulmonary air leaks
Authors: Claire Hathorn, Nicole Armitage, David Wensley, Michael Seear
Journal: European Respiratory Journal (2013)

Background: Pulmonary air leaks in children are most commonly due to infection or barotrauma. While cases of severe barotrauma are falling due to advances in neonatal care, the incidence of necrotising pneumonia is rising. The majority of air leaks can be managed conservatively but more severe cases pose a significant challenge to the clinician. The use of occlusive endobronchial balloons is an established anaesthetic technique for a number of indications, but is not widely used in children.  Methods: We conducted a review over 12 years & report 6 cases of complex air leaks in which balloon occlusion was used.  Results: Balloon occlusion was successful in both cases of bronchopleural fistulae (secondary to severe necrotising pneumonia) & half the cases with intra-pulmonary air leaks. In the other two cases (due to barotrauma & filamin A deficiency), it was transiently effective. No serious adverse effects or complications were encountered.  Conclusions: In selected cases, endobronchial balloons are a useful adjunct in the management of life-threatening bronchopleural fistulae and cystic lung disease. The procedure is non-operative, minimally invasive and reversible. With the increasing incidence of bronchopleural fistulae, this may become an increasingly important therapy.  Serial radiographs from case 1. Left: RUL pneumonia, pneumothorax, pneumomediastinum, subcutaneous emphysema. Middle: balloon inflated in RUL bronchus. Right: follow-up film.
Gene therapy for inherited blindness disorder improves eyesight in short term, study shows
Authors: S. Mayor
Journal: BMJ (2015)

Gene therapy for an inherited disorder that causes vision loss in childhood improves eyesight for one to three years, but the benefits then diminish, two early phase studies have shown.

The researchers said that the studies, published in the New England Journal of Medicine ,1 2 demonstrate the potential benefits and the remaining challenges of using gene therapy to treat retinal conditions.

The two studies treated people with Leber’s congenital amaurosis, a group of conditions that cause blindness early in life owing to mutations in at least 19 different …
Heparin-Induced Thrombocytopenia in Cancer
Authors: Benjamin J. Miriovsky, Thomas L. Ortel
Journal: Journal of the National Comprehensive Cancer Network (2011)

Heparin-induced thrombocytopenia is a common and clinically important drug-induced complication that can cause life- and limbthreatening thrombosis. Epidemiologically, the disease has been studied in many different clinical settings, but little is known about it in cancer patients, a population at increased risk for thrombosis and thus exposure to heparin products. Additionally, thrombocytopenia is a common finding in cancer patients. The convergence of these variables highlights the importance of an increased understanding of the disease in cancer patients.
Investigation of the Nucleic Acids of Viscera and Tumor Tissue from Animals Injected with Radioactive 8-Azaguanine
Authors: Jack H. Mitchell, Howard E. Skipper, Leonard L. Bennett
Journal: Cancer Research (1950)

Summary  1.Radioactive carbon from carbon-labeled 8-azaguanine, at 6 and 24 hours after injection, is found in higher concentrations in the nucleic acid fractions of normal viscera and of Eo771 tumor tissue than in the tissues from which the nucleic acids were isolated.  2.The nucleic acid fraction from Eo771 tumor tissue is no higher in radioactivity than the nucleic acid fraction from normal visceral tissue.  3.8-Azaguanine has been shown to be present in the purines isolated from the ribosenucleic acid fraction of visceral tissue of animals injected with radioactive 8-azaguanine.
Effective and evidence‐based management strategies for rosacea: summary of a Cochrane systematic review
Authors: E.J. van Zuuren, S.F. Kramer, B.R. Carter, M.A. Graber, Z. Fedorowicz
Journal: British Journal of Dermatology (2011)

Rosacea is a common chronic skin disease affecting the face. There are numerous treatment options, but it is unclear which are the most effective. The aim of this review was to assess the evidence for the efficacy and safety of treatments for rosacea. Searches included the Cochrane Skin Group Specialised Register, the Cochrane Central Register of Controlled Trials in The Cochrane Library, MEDLINE, EMBASE, Science Citation Index, and Ongoing Trials Registers (updated February 2011). Randomized controlled trials in people with moderate to severe rosacea were included. Fifty‐eight trials, including 27 from the original review, comprising 6633 participants were included in this updated review. Interventions included topical metronidazole, oral antibiotics, topical azelaic cream or gel, topical benzoyl peroxide and/or combined with topical antibiotics, sulphacetamide/sulphur, and others. There was some evidence that topical metronidazole and azelaic acid were more effective than placebo. Two trials indicated that doxycycline 40 mg was more effective than placebo. There was no statistically significant difference in effectiveness between doxycycline 40 mg and 100 mg but there were fewer adverse effects. One study reported that ciclosporin ophthalmic emulsion was significantly more effective than artificial tears for treating ocular rosacea. Although the majority of included studies were assessed as being at high or unclear risk of bias, there was some evidence to support the effectiveness of topical metronidazole, azelaic acid and doxycycline (40 mg) in the treatment of moderate to severe rosacea, and ciclosporin 0·05% ophthalmic emulsion for ocular rosacea. Further well‐designed, adequately powered randomized controlled trials are required.
Management of Tetanus: A Review of 18 Cases
Authors: K O Sun, Y W Chan, R T F Cheung, P C So, Y L Yu, P C K Li
Journal: Journal of the Royal Society of Medicine (1994)

Eighteen patients with generalized tetanus seen during an 8-year period in three regional hospitals in Hong Kong are reviewed. Eighty-nine per cent of the patients were intravenous heroin addicts who developed a severe type of generalized tetanus with autonomic dysfunction. Pain or stiffness of the neck or back was the commonest presenting symptom, followed by trismus and dysphagia. Most of the patients developed muscle spasms within 24 h of the onset of presenting symptoms. Early ventilatory support and tracheostomy, together with intensive nursing care, were the mainstay of the treatment. Pulmonary and gastrointestinal complications were common during the course of illness and treatment of autonomic dysfunction was often unsatisfactory. The case fatality rate was 25% among the heroin addicts, but full recovery was the usual outcome for those who survived. The simultaneous administration of intrathecal tetanus immunoglobulin tends to reduce mortality.