tbuckley/cabot-search huggingface dataset:
Abstract 4753: Paclitaxel- versus Sirolimus-Eluting Stents for Treatment of ST-segment Elevation Myocardial Infarction: Impact of Diabetes Mellitus
Authors: Han-Mo Yang, Youngjin Cho, Woo-Young Chung, Kyung-Woo Park, Hyun-Jae Kang, Myung-Ho Jeong, Young-Jo Kim, Hyo-Soo Kim, Myeong-Chan Cho, Bon-Kwon Koo, Sue K. Park
Journal: Circulation (2009)
Peer review of prescribing patterns in a CMHC
Authors: H Diamond, R Tislow, T Snyder, K Rickles
Journal: American Journal of Psychiatry (1976)

Monitoring the prescribing patterns of psychiatrists is a challenging and now necessary professional responsibility. The authors describe a peer review and feedback system in a decentralized CMHC, linked to continuing education in psychopharmacology, that made staff psychiatrists familiar with the state of the art and accountable for practice within its guidelines. Data are presented that confirm shifts from polypharmacy toward more appropriate use of psychotropic medications.
All in the Family
Authors: Joshua S. Easter, S. Andrew Josephson, Deborah T. Vinton, Sanjay Saint, Jonathan A. Edlow
Journal: New England Journal of Medicine (2010)

A 34-year-old woman presented to a community hospital with aphasia. Her husband reported that her condition had been normal until 2 hours earlier, when her arms and legs suddenly shook for several seconds. Immediately afterward, she was unable to speak or to move her limbs on the right side.
Abstract 4235: Abnormal Myocardial Deformation Is Associated With Mortality Independent Of Hypertrophy In The Absence of Ischemia
Authors: Tony Stanton, Charlotte Bjork Ingul, James L Hare, Brian Haluska, Thomas H Marwick
Journal: Circulation (2008)

Purpose : Myocardial deformation has been shown to identify subclinical abnormalities in apparently normal hearts. We investigated the association of these markers with mortality after excluding ischemia in individuals undergoing dobutamine stress echocardiography (DSE). Methods : We studied 163 consecutive patients with normal resting LV function and no ischemia at DSE. Mean Bethesda scores indicated a low ten-year risk of coronary disease (men 3.2±2.1%, women 5.3±2.6%). Relative wall thickness (RWT) and LVMI (indexed to height 2.7 ) were calculated according to ASE guidelines. Customized software was used to measure peak systolic SR in 18 segments and mean global SR was calculated. Individuals were followed for all-cause mortality for a mean of 5.4±1.4 years. Results : Mean RWT 0.46±0.11 (normal ≤ 0.42) and mean LVMI was 46.8±13.0g/m 2.7 (normal &lt;51g/m 2.7 ). RWT and LVMI were assessed in the closest approximation to 1 standard deviation (per change of 0.1 for RWT and 10g/m 2.7 for LVMI). In a Cox Proportional Hazards Model the strongest predictor of all-cause mortality was peak systolic SR (HR 3.72, 95%CI 1.8 –7.65, p&lt;0.01). RWT (HR 1.4, 95%CI 1.0 –1.96, p&lt;0.05) was a stronger predictor of all-cause mortality than LVMI (HR 1.2, 95%CI 0.86 –1.96, p=NS). Kaplan Meier curves were constructed by grouping the data into tertiles according to peak systolic SR (p&lt;0.01 overall). Conclusion : Peak systolic strain rate is a significant independent predictor of all-cause mortality, superior to LVMI and RWT. This link between myocardial deformation and outcome in the absence of myocardial ischemia may be consistent with an effect of interstitial changes on mortality.
Abstract 13890: Post-Thrombotic Syndrome in Children with Congenital Heart Disease is Prevalent and Associated with Important Clinical Consequences
Authors: Cedric Manlhiot, Leonardo R Brandao, Suzan Williams, Anthony K Chan, Ines B Menjak, Brian W McCrindle
Journal: Circulation (2011)

Post-thrombotic syndrome (PTS) is increasingly recognized as an important complication of deep venous thrombosis (DVT). Prevalence and relevance for children with congenital heart disease (CHD) has...
Abstract 11932: Mechanical Dispersion Predicts Ventricular Arrhythmias After Myocardial Infarction
Authors: Kristina H Haugaa, Bjornar L Grenne, Jens-Uwe Voigt, Anca Florian, Benthe Sjoli, Harald Brunvand, Christian H Eek, Walter Desmet, Jesper H Svendsen, Otto A Smiseth, Thor Edvardsen
Journal: Circulation (2011)

Introduction Prediction of ventricular arrhythmias after myocardial infarction (MI) is still insufficient. LV ejection fraction (EF)  35%. Mechanical dispersion by strain echocardiography reflects inhomogeneous timing in myocardial contraction and has been shown to predict ventricular arrhythmias. We hypothesized that mechanical dispersion may improve arrhythmic risk stratification in post MI patients. Methods In this prospective multi center study we included 177 post MI patients (114 ST elevation and 63 non-ST elevation). Echocardiography was performed minimum 40 days post MI. Time from ECG R to peak negative strain was assessed in 16 longitudinal LV segments. Mechanical dispersion was assessed as the standard deviation from these 16 time intervals, reflecting contraction heterogeneity. Results Ventricular arrhythmias defined as sustained VT, VF or sudden death duri...
Abstract 3850: The Ratio of Polyunsaturated to Saturated Fatty Acids in the Serum is a Strong Determinant of the Presence of Coronary Calcification Among US White and Japanese Men Aged 40 49
Authors: Hirotsugu Ueshima, Akira Sekikawa, Takashi Kadowaki, Aiman El-Saed, Tomonori Okamura, Kim Sutton-Tyrrell, Yasuyuki Nakamura, Tomoko Takamiya, Kenichi Mitsunami, Rhobert W Evans, Kiyoshi Murata, Daniel Edmundowicz, Yoshikuni Kita, Lewis H Kuller
Journal: Circulation (2006)
Abstract 576: Can Doppler Echocardiography Define Diastolic Heart Failure?
Authors: William L Duvall, Lori B Croft, Adam Zucker, Ziad Sergie, Eric Stern, Samantha Buckley, Martin E Goldman
Journal: Circulation (2009)

Objectives: Almost half of the patients presenting with heart failure (HF) have normal systoic function and are diagnosed with diastolic HF. Three echo Doppler variables utilized to diagnose diasto...
Obituary Listing
Authors: Charles Rainey
Journal: JAMA (1999)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Combined Subaortic and Mid-ventricular Obstruction With Significant Aortic Stenosis Diagnosed by Triphasic Doppler Flow Pattern
Authors: Yasuharu Tanabe, Hiroki Oe, Akihito Miyoshi, Norihisa Toh, Satoko Ugawa, Nobuhisa Watanabe, Masami Takagaki, Shunji Sano, Hiroshi Ito
Journal: Journal of the American College of Cardiology (2012)
Fever from the tropics
Authors: A Colville, R E Stansfield, G Bignardi, J Hovenden, F A. I Riordan
Journal: BMJ (1998)

Editor—Klein and Millman describe 31 children with fever who had recently visited the tropics and presented to their department.1 Many of these children, including the 11 who had visited sub-Saharan Africa, would be likely to fall into the moderate risk category as defined by guidelines published in a document by the Advisory Committee on Dangerous Pathogens.2 This category includes febrile patients who have been in an endemic area during the 21 days before onset of illness. It would be interesting to know if the possibility of viral haemorrhagic fever was considered in any of these children, and if the guidelines were followed.

There are serious implications for the clinical management of patients falling into the moderate risk category. These people can be admitted only to isolation facilities, which have stringent specifications and are not available in most district hospitals. Urgent laboratory investigations are severely limited. If, for example, viral haemorrhagic fever cannot be excluded with certainty only a thin blood film for malaria may be examined outside a high security laboratory for infectious diseases. Only two of these are listed in the guidelines for investigations of these patients—in Coppetts Wood Hospital, London, and Newcastle General Hospital, Newcastle upon Tyne.

With the addition of Congo Crimean haemorrhagic fever to the list of viral haemorrhagic fevers of concern to the United Kingdom, the areas where the disease is potentially endemic have been substantially increased. They now cover countries such as Greece and Turkey, which are popular destinations for British residents.

Insufficient information is given in the document on the distribution of viral haemorrhagic fever and which parts of endemic areas pose a considerable risk for travellers.2 Importation of viral haemorrhagic fever into the United Kingdom is extremely rare, whereas other life threatening infections are more common.1,3 More specific guidance should be available on areas where diseases are endemic—for example, in the form of a regularly updated website or a telephone hotline. This way, most of the visitors to areas currently identified in the document who present with a fever in the United Kingdom could possibly be excluded. Otherwise patients may unnecessarily be transferred over long distances and put at risk by investigation being restricted.

If guidelines are impracticable and unrealistic they may be ignored. The true risk of viral haemorrhagic fever in returning travellers is extremely small. Risk assessment as detailed in the guidelines can be improved, and made more accessible to the general practitioners and hospital doctors who see these patients.
Male rape: offenders and victims
Authors: A. N. Groth, Ann Wolbert Burgess
Journal: American Journal of Psychiatry (1980)

In an analysis of 22 cases of male rape in a community setting, the gender of the victim did not appear to be of primary importance to some of the rapists, but for others, males appeared to be specific intended targets, and the rapists' assaults were an effort to deal with unresolved and conflictual aspects of their lives. For all offenders the sexual assault was an act of retaliation, an expression of power, and an assertion of their strength and manhood. The impact of rape on the male victims was similar to that on female victims, disrupting their biopsychosocial functioning; however, male rape appears to be underreported due to the stigma associated with it.
Abstract 14413: Evaluation of the Acute Coronary Syndrome Safety Profile of Dabigatran Etexilate in Patients Undergoing Major Orthopedic Surgery
Authors: Gregory W Barsness, John S Smith, Bengt I Eriksson, Joseph Caprini, Stefan Hantel, Andreas Clemens, Martin Feuring, Janet Schnee
Journal: Circulation (2011)

Introduction: Stopping anticoagulant therapy may lead to increased cardiovascular events via a so called ‘rebound phenomenon’. We studied the incidence of acute coronary syndrome (ACS) events durin...
Abstract 14851: Predictors of Death Within Six Months of Cardiac Resynchronisation Therapy
Authors: Darryl P Leong, Ulas Hoke, Jeroen J Bax, Victoria Delgado, Dominique Auger, Kai H Yiu, Elena Abate, Joep Thijssen, Martin J Schalij, Nina Ajmone Marsan
Journal: Circulation (2011)

Purpose Although predictors of poor long-term outcome following cardiac resychronization therapy (CRT) have been identified, contributors to early mortality after CRT are poorly characterized. The ...
Abstract 3123: Prolonged QRS Duration is Associated with Abnormal Left Ventricular Function, but not with Subclinical Atherosclerosis in Adults without Clinical Cardiovascular Disease - The Multi-Ethnic Study of Atherosclerosis (MESA) Study
Authors: Liviu Klein, Philip Greenland, Cheeling Chan, Harikrishna Tandri, David Bluemke, Ronald Prineas
Journal: Circulation (2008)
Abstract 16171: Carbon Nanotubes Enable Optical Ablation of Vascular Macrophages
Authors: Hisanori Kosuge, Sarah Sherlock, Toshiro Kitagawa, Hongjie Dai, Michael V McConnell
Journal: Circulation (2011)

Introduction: Macrophages are important targets for detection and therapy of atherosclerosis. Carbon nanotubes (NT) have imaging and therapeutic properties, as they can heat/ablate cells through op...
Abstract 445: Phosphatase Inhibitor-1 is Critically Involved in Acute and Chronic Catecholamine Stress Responses
Authors: Ali El-Armouche, Franziska Degenhardt, Florian Weinberger, Fabian Gocht, Katrin Wittkopper, Ivan Melnychenko, Michael Didie, Wolfram H Zimmermann, Michael Grimm, Thomas Eschenhagen
Journal: Circulation (2006)

Desensitization of the β-adrenoceptor/cAMP/PKA system is a hallmark of heart failure. The PKA-phosphorylated inhibitor-1 (I-1) amplifies β-adrenergic signaling via inhibition of type-1 phosphatases. I-1 is markedly downregulated in failing human hearts. To test whether this is a consequence of the excessive adrenergic drive in heart failure, rats were treated via minipumps with 2.4 mg/kgxd isoprenaline (ISO, n=7) or 0.9% NaCl (n=8) for 4 d. In ISO-treated rats, heart-to-body weight ratio (HW/BW) increased by 28±3% and I-1 protein levels were downregulated by 61±29%. To address whether a decrease in I-1 protects from or aggravates cardiac remodeling we evaluated mice with targeted disruption of the I-1 gene (KO). KO were phenotypically normal (HW/BW 4.8±0.1 vs. 4.7±0.1 mg/g in WT, n=16), but showed a rightward shift of the ISO concentration-response curve in isolated left atria preparations (EC50 40.9 vs. 23.9 nM, n=12). This observation was compatible with the proposed amplifier role of I-1 and suggested ...
A Primate Model of Anterior Segment ischemia after Strabismus Surgery
Authors: Peggy H. Fishman, Michael X. Repka, W. Richard Green, Salvatore A. D'Anna, David L. Guyton
Journal: Ophthalmology (1990)

Fornix conjunctival incisions in strabismus surgery may provide partial protection against anterior segment ischemia by preserving the perilimbal conjunctival-Tenon's circulation, which is disrupted with limbal conjunctival incisions. Six adult cynomolgus monkeys underwent tenotomies of three or four rectus muscles by making limbal conjunctival incisions in one eye and fornix incisions in the other. Iris fluorescein angiography and slit-lamp biomicroscopy were used to monitor changes. The eyes that had limbal incisions exhibited more severe anterior segment ischemic changes than the eyes that had fornix incisions in every instance of four rectus muscle surgery.
Identification of a Region of PfEMP1 That Mediates Adherence of Plasmodium falciparum Infected Erythrocytes to CD36: Conserved Function With Variant Sequence
Authors: Dror I. Baruch, Xin C. Ma, Hardeep B. Singh, Xiahui Bi, Brittan L. Pasloske, Russell J. Howard
Journal: Blood (1997)
2008 Distinguished Scientist Lecture—MicroRNA Control of Heart Disease: From New Biology to New Therapeutics
Authors: Eric N. Olson
Journal: Circulation (2008)

MicroRNAs act as negative regulators of gene expression by inhibiting the translation or promoting the degradation of target mRNAs. Because individual microRNAs often regulate the expression of multiple target genes with related functions, modulating the expression of a single microRNA can, in principle, influence an entire gene network and thereby modify complex disease phenotypes. We have identified signature expression patterns of microRNAs associated with pathological cardiac hypertrophy, heart failure, and myocardial infarction in humans and mouse models of heart disease. Gain- and loss-of-function studies in mice have revealed profound and unexpected functions for these microRNAs in numerous facets of cardiac biology, including the control of myocyte growth, contractility, energy metabolism, fibrosis, and angiogenesis, providing glimpses of new regulatory mechanisms and potential therapeutic targets for heart disease. Especially intriguing is the discovery of a network of muscle-specific microRNAs embedded within myosin heavy chain genes, which control myosin expression and the response of the heart to stress and thyroid hormone signaling. Recent studies have demonstrated that disease-inducing cardiac microRNAs can be persistently silenced in vivo through systemic delivery of anti-miRs, allowing for the direct therapeutic modulation of disease mechanisms. The myriad roles of microRNAs in the control of cardiac function and dysfunction and therapeutic opportunities for manipulating microRNA biology in the setting of heart disease will be discussed.
London group's findings supported by study in Leeds
Authors: S. H Cray
Journal: BMJ (1996)

EDITOR,—I was interested to read the paper describing the experience of the paediatric retrieval team at St Mary's Hospital in London,1 having recently reported a similar study of the paediatric retrieval service based at Leeds General Infirmary.2 Our study of 50 children referred for transfer by a specialist retrieval team over six months used two scores derived from the paediatric risk of mortality and the therapeutic intervention scoring system to assess …
Abstract 14883: Texting Teens in Transition: The Use of Social Networking in Clinical Intervention Research
Authors: Ross T Ballantyne, Louisa Fricker, Cheri Robert, Michelle Duffley, Sandra Caligiuri, David Nicholas, Joyce Magill-Evans, Andrew Mackie, Gwen R Rempel
Journal: Circulation (2012)

Advances in the care of children with congenital heart disease (CHD) have enabled many to survive previously fatal conditions. The number of these children surviving into adulthood has increased at...
Abstract 1490: The Targeting Of Cyclophilin D By RNA Interference As A Novel Therapeutic Strategy Against Myocardial Ischemia/Reperfusion Injury
Authors: Masashi Kato, Masaharu Akao, Takeru Makiyama, Madoka Matsumoto-Ida, Moritake Iguchi, Toshihiro Takeda, Toru Kita
Journal: Circulation (2007)

Background- An opening of the mitochondrial permeability transition pore (MPTP), which leads to loss of mitochondrial membrane potential (ΔΨ m ) and mitochondrial dysfunction, is the earliest event that commits cells to death, and this process is potentially a prime target for therapeutic intervention against myocardial ischemia/reperfusion. We examined the effects of genetic knock-down of cyclophilin D (CypD), one of the putative components of MPTP, using RNA interference. Methods and Results- We created an adenovirus carrying short interfering RNA (siRNA) which inactivates CypD. Transduction of siRNA-CypD in cultured neonatal rat cardiomyocytes achieved 68% reduction in mRNA and 61% reduction in protein levels, and suppressed cell death induced by H 2 O 2 (100μM) as assessed by cell viability assay. It also protected against ΔΨ m loss, as assessed by both time-lapse confocal microscopy and fluorescence-activated cell sorter analysis of cardiomyocytes loaded with an indicator of ΔΨ m, tetramethylrhodamine ethylester (TMRE). To further investigate the effects in vivo, we monitored the spatio-temporal changes of ΔΨ m in perfused rat hearts subjected to ischemia/reperfusion, using the real-time two-photon confocal imaging system which we recently developed. Briefly, adult rats received direct intramyocardial injections of the siRNA-CypD adenovirus. 3–5 days after injection, the rat hearts were removed and perfused in Langendorff mode. After loading TMRE, the hearts underwent two-photon imaging under excitation with 810 nm line of a Ti:Sapphire laser. Ischemia was achieved by clamping the perfusion line, and reperfusion was achieved by releasing the clamp. The virus contained an expression cassette of green fluorescent protein, allowing us to distinguish transduced cells and non-transduced cells. The progressive loss of ΔΨ m induced by myocardial ischemia/ reperfusion was significantly suppressed in siRNA-CypD-transduced cells, compared with non-transduced cells. Conclusions- Targeting CypD by RNA interference protects against oxidant-induced cardiomyocyte injury in vitro, and myocardial ischemia/reperfusion in vivo, implicating CypD as a promising molecular target for anti-ischemia/reperfusion therapy.
Abstract 18407: Nucleolar Stress is an Early Response to Stress in Cardiac Cells: Role of the Nucleolar Proteins Nucleostemin and Nucleophosmin
Authors: Daniele Avitabile, Natalie Gude, Aryan Zaraby, Zhaokang Cheng, Matt Mason, Kimberlee Fisher, Shabana Din, Silvia Truffa, Balaji Sundararaman, Roberto Alvarez, Mathias Konstandin, Mark Sussman
Journal: Circulation (2010)

Introduction:  Nucleolar integrity is essential to maintain ribosome biogenesis, control cell proliferation, and the cellular stress response. Nucleolar stress, characterized by loss of nucleolar integrity, has not been described in the cardiac context. Previously we demonstrated a role for the nucleolar protein nucleostemin (NS) in the cardiac response to pathological insult. NS is known to interact with nucleophosmin (NPM), a marker of nucleolar stress with cytoprotective properties. Doxorubicin (DOX) induces nucleolar stress in non cardiac cells. In this study, we show that nucleolar stress is an early event in doxorubicin mediated cardiotoxicity as measured by the dynamic behavior of NS and NPM in vitro and in vivo.   Methods:  Neonatal rat cardiomyocytes (NRCM) and cardiac progenitor cells (CPC) were treated with 1μM DOX, 0.05 μg/ml Actinomycin D (ActD) or DMSO. NS and NPM were knocked down in CPC by specific shRNA expressing vectors. NPM function was ablated in NRCM by the inhibitor NSC348883. In vivo, 7 day old mice received a single dose of DOX 15 mg/kg or saline control and sacrificed 24h later. Confocal microscopy, WB, qRT-PCR and FACS were employed in this study to assess NS and NPM localization, protein and transcript levels, and cell death respectively.   Results:  DOX and ActD induced NS and NPM delocalization into the nucleoplasm within 4h in NRCM and 6h in CPC. In NRCM, nucleolar disruption was associated with suppression of new 45S pre-rRNA synthesis. At 24h, NS protein levels decreased by 13% and 34% in NRCM and CPC respectively. Cell death significantly increased at 16h in NRCM and at 24h in CPC, suggesting that nucleolar stress precedes DOX induced cytotoxity. Moreover, downregulation of NS and NPM function significantly increased DOX-induced cell death both in NRCM and CPC. We obtained similar results in hearts from DOX treated mice, observing a 20% decrease in NS protein levels and 1.7 fold reduction in pre-rRNA 45S transcripts.   Conclusion:  Our results are the first demonstration of nucleolar stress in cardiac cells as well as associating DOX toxicity with impairment of nucleolar function. Our findings point to preservation of nucleolar integrity as a new strategy for protection against DOX mediated cardiomyopathy and other cellular stresses.