PHYSIOLOGIC AND CLINICAL ASPECTS OF PULMONARY ALVEOLAR PROTEINOSIS
Authors: W FRAIMOW, R T CATHCART, R C TAYLOR
Journal: Annals of Internal Medicine (1960)

Article1 June 1960PHYSIOLOGIC AND CLINICAL ASPECTS OF PULMONARY ALVEOLAR PROTEINOSISWILLIAM FRAIMOW, RICHARD T. CATHCART, RICHARD C. TAYLORWILLIAM FRAIMOWSearch for more papers by this author, RICHARD T. CATHCARTSearch for more papers by this author, RICHARD C. TAYLORSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-52-6-1177 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe recently described disease, pulmonary alveolar proteinosis,1has aroused much clinical and pathologic interest. This disease bears a significant mortality (30%) in the reported cases. Death is the result of progressive pulmonary insufficiency, hastened at times by complicating secondary infection. A patient followed by this laboratory and previously reported demonstrated the presence of alveolar-capillary block.2Since then, the almost identical physiologic findings in additional patients would seem to establish this picture conclusively as the expected physiologic abnormality in this condition. These abnormalities are related to specific histologic aberrations typically found in alveolar proteinosis. Its features are quite unlike the changes...Bibliography1. RosenCastlemanLiebow SHBAA: Pulmonary alveolar proteinosis, New England J. Med. 258: 1123-1146, 1958. CrossrefMedlineGoogle Scholar2. FraimowCathcartKirshnerTaylor WRTJJRC: Pulmonary alveolar proteinosis: a correlation of pathological and physiological findings in a case followed with serial lung biopsies, Am. J. Med. 28: 458-467 (Mar.) 1960. CrossrefMedlineGoogle Scholar3. 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Staff Meet., Mayo Clin. 34: 152, 1959. MedlineGoogle Scholar19. LevinsonJonesWintrobeCartwright BRSMMGE: Thrombocythemia and pulmonary intra-alveolar coagulum in a young woman, Blood 13: 959, 1958. CrossrefMedlineGoogle Scholar20. LilienthalRileyProemmelFranke JLRLDDRE: An experimental analysis in man of the oxygen pressure gradient from alveolar air to arterial blood during rest and exercise at sea level and altitude, Am. J. Physiol. 147: 199, 1946. CrossrefMedlineGoogle Scholar21. Rosen SH: Personal communication. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Philadelphia, Pennsylvania*Received for publication February 5, 1960.From the Barton Memorial Division of Jefferson Medical College Hospital, Philadelphia, Pennsylvania.†This work was supported by the Anthracite Health and Welfare Fund.Requests for reprints should be addressed to Richard T. Cathcart, M.D., Director, Cardiorespiratory Laboratory, Jefferson Medical College Hospital, Barton Memorial Division, Broad and Fitzwater Streets, Philadelphia 47, Pennsylvania. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byAutoimmune Pulmonary Alveolar ProteinosisPulmonary Alveolar ProteinosisPulmonary Alveolar ProteinosisCase 42-1992Pulmonary Alveolar Phospholipoproteinosis: Experience With 34 Cases and a ReviewPulmonary Alveolar ProteinosisUpdate on the Clinical Diagnosis, Management, and Pathogenesis of Pulmonary Alveolar Proteinosis (Phospholipidosis)Defective Lung Macrophages in Pulmonary Alveolar ProteinosisDAVID W. GOLDE, M.D., F.A.C.P., MARY TERRITO, M.D., THEODORE N. FINLEY, M.D., MARTIN J. 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WILSON, M.D.Über die alveoläre LungenproteinosePulmonary Alveolar Proteinosis: A Review of the LiteratureA Fatal Case of Pulmonary Alveolar Proteinosis 1 June 1960Volume 52, Issue 6Page: 1177-1194KeywordsMortalityProteinsPulmonary diseasesResearch laboratoriesRespiratory physiology ePublished: 1 December 2008 Issue Published: 1 June 1960 Copyright & PermissionsCopyright ©, 1960, by The American College of PhysiciansPDF downloadLoading ...