tbuckley/cabot-search huggingface dataset:
Abstract 302: The Importance of Adhesion in Multipotent Stromal Cell-Induced Coronary Collateral Growth/Arteriogenesis
Authors: Souad Belmadani, Darwin Prockop, William Chilian
Journal: Circulation (2007)

Because of the potential of stem cells and stromal cells to differentiate into vascular cells, their most salubrious role in the treatment of patients with ischemic heart disease may be as prophylactic agents preventing infarction by stimulating coronary collateral growth (CCG). Therefore, we determined if multipotent stromal cells (MSCs: CD59+, CD90+) would amplify CCG in a rat model of ischemia, but without infarction. Rats were instrumented with a pneumatic snare around the left anterior descending artery and subjected to repetitive ischemia (RI: 24 40 sec occlusions/day for 10 days) to stimulate CCG. CCG was determined from the ratio of flows (radioactive microspheres) to the collateral-dependent (during LAD occlusion) and normal zones (CZ/NZ, where 1.0, indicates CCG has completely restored flow to the area at risk). After RI, CZ/NZ was 0.33±0.04, which was greater than in shams indicating RI stimulated collateral growth. In rats treated with MSCs (intraventricular injection of 8 x 10 5 at the time of initial surgery), CZ/NZ was 0.51±0.01 (p&lt;0.05 vs RI). Because the RI protocol does not produce severe tissue injury, we reasoned that the multipotent stromal cells might not home properly to the tissue; therefore we determined if amplification of MSCs adhesion would augment CCG. To accomplish this we ascertained that MSCs adhesion to endothelial monolayers in vitro was augmented (~3X) by treatment with EGF, that we found to upregulate adhesion molecule expression. Injection of EGF-treated MSCs increased CZ/NZ to 0.75±0.07 (p&lt;0.05 vs RI and RI+BMSC). Labeling of MSCs with DiI showed that EGF treatment increased the number of labeled cells in the myocardium and vascular tissues. The fraction shortening (FS, echocardiography) was significantly decreased in the RI group 25.4±0.5% vs sham (37.2±0.3%, p&lt;0.05 vs RI). However, injection of EGF-treated MSCs increased FS significantly (33.4±1.3%) vs RI and RI+MSCs (p&lt;0.05), demonstrating that the increase in collateral flow was functionally significant. Thus MSCs may prove to be effective therapies for the stimulation of coronary collateral growth, but appear to be more effective after interventions are employed to increase their adhesion and homing (in vitro EGF treatment) to the jeopardized myocardium.
Body-mass index and mortality among white adults.
Authors: Timothy A Welborn, Satvinder S Dhaliwal
Journal: New England Journal of Medicine (2011)

n engl j med 364;8 nejm.org february 24, 2011 781 Gimenez-Perez raises potential long-term safety concerns about high-protein, low-carbohydrate diets as well as the source of protein (animal vs. vegetable) and asks whether this might have an effect on deaths from any cause, cardiovascular disease, and cancer, given the conclusions of a recent article on a low-carbohydrate diet with a high intake of animal protein. In our study, which did not involve low-carbohydrate diets, the total dietary protein originated both from animal and vegetable sources, partly varying according to differences in dietary habits in the involved countries. Information about the dietary strategies was reported previously.1 Thomas Meinert Larsen, Ph.D.
Abstract 14779: Triple Versus Dual Antiplatelet Therapy in Acute Myocardial Infarction in Relation to Renal Function
Authors: Weon Kim, Jong Shin Woo, Woo Shik Kim, Jin Bae Kim, Kwon sam Kim
Journal: Circulation (2011)

Background: Chronic kidney disease (CKD) is a strong risk factor for cardiovascular events, and there are consistence evidences about worse short- and long-term outcomes in CKD patients with acute ...
Novel R41Q-PAR1-Modified Mice Enable Proof-of-Concept Studies for in Vivo Mechanisms of Action for Thrombin (IIa) and Activated Protein C (APC)
Authors: Ranjeet Kumar Sinha, Laurent Burnier, Naveen Gupta, Xiao Xu, Sergey Kupriyanov, Greg Martin, Laurent O. Mosnier, John H. Griffin
Journal: Blood (2014)
Colchicine for Post-Operative Pericardial Effusion
Authors: Philippe Meurin, Sophie Lelay-Kubas, Bernard Pierre, Helena Pereira, Bruno Pavy, Marie Christine Iliou, Jean Louis Bussiere, Helene Weber, Jean Pierre Beugin, Titi Farrokhi, Anne Bellemain-Appaix, Laura Briota, Jean-Yves Tabet
Journal: Journal of the American College of Cardiology (2015)
Twin concordance for attention deficit hyperactivity disorder: a comparison of teachers' and mothers' reports
Authors: D K Sherman, M K McGue, W G Iacono
Journal: American Journal of Psychiatry (1997)

The present study examined probandwise concordance rates for attention deficit hyperactivity disorder (ADHD) in a community sample of 194 monozygotic and 94 dizygotic male twins, ages 11-12 years.DSM-III and DSM-III-R diagnoses of ADHD were based on rating scale reports from the twins' teachers and structured interview reports obtained from their mothers. Model-fitting analyses were used to estimate genetic and environmental effects on ADHD.Concordance rates for ADHD were greater for monozygotic than dizygotic twins according to both mothers' and teachers' reports; this finding indicates the importance of genetic factors in the etiology of this syndrome. Fifteen percent of subjects received an ADHD diagnosis by teachers' ratings, compared with 6% by mothers' reports. Three percent of subjects met criteria for ADHD in both school and home settings. Teachers' ratings yielded moderate monozygotic and dizygotic concordance rates, in contrast to mothers' reports, which indicated a high monozygotic and a zero dizygotic concordance for ADHD. A model that included additive genetic and nonshared environmental factors provided the best fit to these ADHD data.ADHD, as defined by DSM criteria, appears to be a genetically influenced disorder whether diagnoses are based on teachers' or mothers' reports. However, the extent of this genetic influence seems to vary by informant source. These findings suggest that obtaining diagnostic data from either teachers' or mothers' reports alone may provide an incomplete characterization of ADHD.
Abstract 14723: Sirolimus Eluting Stent is Superior to Paclitaxel Eluting Stent in patients with Chronic Renal Insufficiency.
Authors: Soe Hee Ann, Ki-Bae Seung, Kiyuk Chang, Hun-Jun Park, Jong Min Lee, Yoon Seok Koh, Sang-Hyun Ihm, Jung Yeon Chin, Jung Eun Lee, Tae-Seok Kim, Tae Hun Kim
Journal: Circulation (2011)

Introduction: Patients with chronic renal insufficiency (CRI) have been reported having high incidence of mortality, stent thrombosis and restenosis after percutaneous coronary intervention (PCI). ...
Abstract 9542: Effects of Aerobic Exercise on Biomarkers After an Implantable Defibrillator (ICD)
Authors: Gayle L Flo, Cynthia M Dougherty, Robert L Burr, Peter J Kudenchuk, Robb Glenny
Journal: Circulation (2011)

Aerobic exercise reduces risk factors for CVD and improves cardiac mortality. However, the effects of aerobic exercise on cardiac function in those with an implantable cardioverter defibrillator (ICD) has not been well described. Aerobic exercise that is carried out without a signifiant increase in arrhythmias or a reduction in cardiac function would be considered safe and hold promise for prescribing exercise in this population. The purpose of this study is to describe the effects of moderate intensity aerobic exercise on B-type naturetic peptide (BNP) in those who have an ICD. Methods: Patients with ICDs (primary or secondary prevention) were randomized to either 8 weeks of aerobic conditioning exercise [home walking 1 hour/day on 5 days/week at 60-80% of maximum HR] or usual care. Usual care patients did not significantly change their level of activity during the 8 week period. Serum BNP was measured in a non-fasting state before the exercise program and again at 8 weeks. Results: 117 subjects completed baseline and 8 week follow-ups (59 usual care and 58 exercise, age 55.6±12.3; male 78%; primary prevention ICD 40%; Caucasian 83%; EF% 39.7±16; BMI 29.3±5.9). 100% of patients were taking beta blockers, 61% ACE inhibitors, 29% diuretics, 8% had DM, 40% had MI, 55% with HF, and 29% had hypertension. Overall, 83% in the exercise group met the expected total days of walking/week and 99% have met the exercise time requirement. Comparisons (mean+SD) between exercise and usual care groups on BNP at 8 weeks indicated that there was no significant difference in BNP with exercise (usual care 202.66+365.93 vs exercise 222.34+249.7, t=0.95, p=0.21). Additionally, 51% had baseline BNP values that were elevated (&gt; 101 mg/dl). For those in the exercise group that had elevated baseline BNP levels, BNP was reduced with exercise (273+181 to 242+203). This was not true for usual care (236+165 to 250+214). A repeated measures factorial interaction test of [group x BNP level] was significant (F[1,113]=6.581, p= 0.012). Conclusions: Home walking exercise for 5 hours/week x 8 weeks in those with an ICD can be completed without significant increases in serum BNP. The level of exercise prescribed can be safely performed in patients with an ICD without significant increases in HF symptoms or BNP.
Risk measures expressed as frequencies may have a more rational response
Authors: P. Ayton
Journal: BMJ (1995)

by 25% to 33% overall.Of more importance is that the proportion of children with extended illness- that is, those who do not experience signs of improvement until after the fourth day of illness- was reduced from 20% to 3% in placebo controlled clinical trials.`"In other words, those who need it most benefit most.What price tag can we attach to that?D J Paynton's family probably did not experience the usual situation of secondary cases in the family being more severe than the index case.My family was less fortunate.One winter before oral acyclovir was available my three children had chickenpox one after the other in painfully slow succession.My son, the tertiary case, was nearly admitted to hospital because of central nervous system complications that were, in retrospect, due to a concomitant infection with influenza A virus.The service implication of an additional treat- ment option is a valid concern.My suggestion would be to set up a triage system so that only questionable cases need be seen by a practitioner.In my experience, the parents or guardians are reliable at recognising chickenpox, epecially after they have suffered through the index case.
Dissociation in women with chronic pelvic pain
Authors: Edward A. Walker, Wayne J. Katon, Kathryn Neraas, Ron P. Jemelka, Donna Massoth
Journal: American Journal of Psychiatry (1992)

The authors' goal was to determine if women with chronic pelvic pain are significantly more likely to use dissociation as a coping mechanism than women without pain.The subjects were recruited from women who attended a university women's clinic during a 1-month period. Twenty-two women who reported that they had at any time in their lives experienced pelvic pain nearly every day for a period of at least 6 months were included in the study, along with 21 randomly selected women without a history of chronic pelvic pain. The 43 women were given structured sexual assault interviews and completed psychological self-report measures.The women with chronic pain were significantly more likely to use dissociation as a coping mechanism, to show current psychological distress, to see themselves as medically disabled, to experience vocational and social decrements in function, and to amplify physical symptoms. They were also significantly more likely to have experienced severe childhood sexual abuse. In the total study group, women with a childhood history of sexual abuse had significantly higher scores on measures of psychological distress, somatization, and dissociation and viewed their physical health and functioning as more impaired.The authors discuss a model for the development of somatization, dissociation, and pain symptoms in victims of early sexual abuse.
Erosion Of The Chronic Myeloid Leukemia Stem Cell Pool By PPARγ Agonists
Authors: Stephane Prost, Francis Relouzat, Marc Spenchian, Gérald Massonnet, Jean-Paul Beressi, Els Verhoeyen, Benjamin Maneglier, Sylvie Castaigne, Christine Chomienne, Stany Chretien, Philippe Rousselot, Philippe Leboulch
Journal: Blood (2013)
Abstract 17806: Progressive Myocardial Tissue Injury Immediately After Coronary Reperfusion Can be Assessed by Ultrasonic Integrated Backscatter
Authors: Minako Katayama, Panupong Jiamsripong, Eileen M McMahon, Anna Boukatina, Jacquelyn M Lombari, Theresa R Lombari, Marek Belohlavek
Journal: Circulation (2011)

Background: Myocardial reperfusion following prolonged ischemia may paradoxically cause additional injury, including edema and microvascular damage. These structural alterations augment tissue echogenicity measurable by integrated backscatter (IB). We sought to characterize alterations of myocardial IB in an ischemic and then reperfused region of the rat heart. Methods: Myocardial IB in 12 adult male Sprague-Dawley rats was studied at baseline, 60 minutes after left anterior descending coronary artery occlusion, and chronologically after coronary reopening. Short-axis scans of the mid left ventricle were acquired at a frequency of 8 MHz. Mean±SD values of IB were measured in the region of interest at baseline, ischemia, and reperfusion, and assessed by a paired t-test. Results: See figure and table. IB did not significantly change between baseline and ischemia. However, within 1 minute of reperfusion, IB significantly increased, as compared to both baseline and ischemia, and continued to increase until 10 minutes after reperfusion, when a plateau was reached. Conclusions: Myocardial reperfusion following acute prolonged ischemia in a rat heart significantly augments tissue echogenicity. A continuing increase of IB within minutes of the reperfusion onset and the subsequent plateau of elevated IB values suggest progression and completion, respectively, of reperfusion injury, detectable by a high-frequency transducer.
Endocrine-Disrupting Chemicals and Oil and Natural Gas Operations: Potential Environmental Contamination and Recommendations to Assess Complex Environmental Mixtures
Authors: Christopher D. Kassotis, Donald E. Tillitt, Chung-Ho Lin, Jane A. McElroy, Susan C. Nagel
Journal: Environmental Health Perspectives (2015)

Hydraulic fracturing technologies, developed over the last 65 years, have only recently been combined with horizontal drilling to unlock oil and gas reserves previously deemed inaccessible. Although these technologies have dramatically increased domestic oil and natural gas production, they have also raised concerns for the potential contamination of local water supplies with the approximately 1,000 chemicals that are used throughout the process, including many known or suspected endocrine-disrupting chemicals.We discuss the need for an endocrine component to health assessments for drilling-dense regions in the context of hormonal and antihormonal activities for chemicals used.We discuss the literature on a) surface and groundwater contamination by oil and gas extraction operations, and b) potential human exposure, particularly in the context of the total hormonal and antihormonal activities present in surface and groundwater from natural and anthropogenic sources; we also discuss initial analytical results and critical knowledge gaps.In light of the potential for environmental release of oil and gas chemicals that can disrupt hormone receptor systems, we recommend methods for assessing complex hormonally active environmental mixtures.We describe a need for an endocrine-centric component for overall health assessments and provide information supporting the idea that using such a component will help explain reported adverse health trends as well as help develop recommendations for environmental impact assessments and monitoring programs.
Mismatch repair status plays a role in radiosensitization by gemcitabine
Authors: Sheryl A. Flanagan, Blaine W. Robinson, Donna S. Shewach
Journal: Cancer Research (2006)

Proc Amer Assoc Cancer Res, Volume 47, 2006

4641 

The chemotherapeutic drug gemcitabine (2’,2’-difluroro-2’-deoxycytidine;dFdCyd) is a potent radiosensitizer in tumor cells and in vivo . Incorporation of dFdCTP into DNA correlates with cytotoxicity and inhibition of ribonucleotide reductase (RR) by dFdCDP results in the depletion of dATP which is strongly correlated to radiosensitization. We hypothesized that radiosensitization by dFdCyd is the result of incorrect nucleotide incorporation into DNA, produced by DNA replication in the presence of imbalanced dNTP pools, which, if not repaired, augments cell death following irradiation. This hypothesis was supported by the finding that mismatch repair (MMR)-deficient HCT116 cells were better radiosensitized by dFdCyd compared to isogenic MMR-proficient cell lines. The plasmid shuttle vector pSP189 was used to examine the ability of dFdCyd to produce nucleotide misincorporations by measuring plasmid mutation rates in the MMR-deficient and MMR-proficient cell lines. Only the MMR-deficient cells showed significant nucleotide misincorporations after incubation with dFdCyd, with a ≥ 2-fold increase in mutation rate (p ≤ 0.01). Furthermore, the increased mutation frequency occurred only at dFdCyd concentrations that produced radiosensitization. Treatment with dFdCyd for 24 hr + 5 Gy produced a ≥ 2-fold increase in the plasmid mutation rates. However, 72 hr after treatment this increase persisted only in the group that received both dFdCyd and 5 Gy (p < 0.05). While MMR-proficient HCT116 cells and A549 cells cannot be radiosensitized with dFdCyd at concentrations ≤ IC50 or ≤ IC10, respectively, these concentrations produced excellent radiosensitization following siRNA directed knockdown of hMLH1 protein. Furthermore, plasmid mutation rates observed in A549MLH1- cells with 10 nM dFdCyd (IC10) were 2.5-fold greater than observed in the A549MLH1+ control cells. To further evaluate the relative roles of RR inhibition by dFdCDP vs. dFdCTP incorporation into DNA as the cause of the increase in mutation frequency with dFdCyd, we treated cells with the RR inhibitor hydroxyurea (HU) or the nucleoside analog cytosine arabinoside (araC). When HCT116 cell lines were treated with the IC50 for HU, only the MMR-deficient cell lines were radiosensitized and produced increased nucleotide misincorporations. Treatment with araC, which can be incorporated into DNA but does not inhibit RR, failed to produce radiosensitization in MMR-deficient cell lines and did not increase plasmid mutation frequency. However, the combination of HU and araC produced a 2-fold increase in mutation frequency (p< 0.05). These results support earlier correlative studies that suggest the action of dFdCDP on RR as the mechanism underlying radiosensitization by dFdCyd. Finally, these data provide evidence that the mismatched nucleotide lesion is integral to radiosensitization by dFdCyd and support a role for MMR status in eliciting the radiosensitizing effect.
P0829 : On-treatment HCVRNA as a predictor of sustained virologic response in HCV genotype 3 infected patients treated with daclatasvir and sofosbuvir: analysis of phase 3 ALLY-3 study
Authors: K. Kowdley, D. Nelson, J. Lalezari, T. Box, N. Gitlin, G. Poleynard, M. Rabinovitz, N. Ravendhran, A. Sheikh, A. Siddique, R. Bhore, P.D. Yin, S. Noviello, K. Rana
Journal: Journal of Hepatology (2015)
Abstract 4180: Role of Gender, Age and MI Type on In Hospital Mortality Following Acute Myocardial Infarction: Results from 361,429 patients in NRMI 3–5
Authors: Kimberly P Champney, Paul D Frederick, Héctor Bueno, Susmita Mallik, JoAnne Foody, Noel Bairey-Merz, John G Canto, Viola Vaccarino
Journal: Circulation (2006)

Background: Previous reports have shown that younger women, but not older women, have higher mortality after MI compared to men, but studies have included mostly NSTEMI patients. We sought to determine gender differences in hospital mortality for both younger and older women according to MI type, e.g. STEMI and NSTEMI. Methods: We studied 126,172 STEMI and 235,257 NSTEMI patients enrolled in the NRMI registry between July 2000 and February 2006. Patients with preexisting LBBB and missing or normal troponin were excluded. Unadjusted and adjusted female to male relative risks (RR) for hospital death were calculated for 10-year age groups. Log-binomial models adjusted for demographic and clinical factors. Results : In both STEMI and NSTEMI, younger women, but not older women, had a higher unadjusted RR for hospital mortality than men. The RR decreased with increasing age (p&lt;.01 for the age-gender interaction). Among NSTEMI, after adjusting for race, medical history, primary payor, and presentation characteristics there was no longer a significant gender difference in mortality in younger women, while older women (70+) had better survival compared to men (Figure ). Among STEMI, younger women continued to have a higher, albeit attenuated, risk for in-hospital mortality up to age 70, while there was no mortality difference between older men and women. Conclusions: Only younger women with STEMI, but not NSTEMI, have higher adjusted mortality compared with men. Older women with STEMI and NSTEMI have improved outcomes compared with men. Possible sex differences in pathophys-iology of younger women with STEMI and gender differences in treatment of this patient population should be explored.
Abstract 11249: Colchicine Can Reduce Early Recurrence of Atrial Fibrillation after Pulmonary Vein Isolation
Authors: Yasuyuki Egami, Masami Nishino, Jun Tanouchi, Yoshio Yamada
Journal: Circulation (2012)

Background: Early recurrence of atrial fibrillation (AF) after pulmonary vein isolation (PVI) was closely related with an acute inflammatory process including high body temperature, increased high-sensitive C-reactive protein (hs-CRP) and presence of signs of pericarditis. It was reported that colchicine reduced the incidence of postoperative atrial fibrillation after cardiac surgery without complications. In this study, we investigated whether colchicine prevent early recurrence of AF after single PVI. Methods: We studied 33 patients (mean age: 64±7 years, 18 males) who underwent single PVI for paroxysmal AF. Subjects were assigned to colchicine group (n=13) and control group (n=20) randomly. In colchicine group, patients were treated with a maintenance dose of 0.5 mg once daily for 2 weeks after PVI. No patients received anti-arrhythmic drug after PVI. The study endpoint was defined as the incidence of AF lasting > 30 sec within 2 weeks following AF ablation. Inflammatory parameters including pre-ablati...