tbuckley/cabot-search huggingface dataset:
Abstract LB-481: MicroRNAs as novel therapeutic targets to treat drug-resistant breast cancers
Authors: Yao-Fu Chang, Behyar Zoghi, Subbarayalu Panneerdoss, Alexander Pertsemlidis, Manjeet K. Rao
Journal: Cancer Research (2012)

Abstract Acquired drug resistance continues to be a major clinical impediment to the successful treatment of cancer. For example, resistance to agents such as paclitaxel and trastuzumab accounts for treatment failure in more than 90% of patients with metastatic breast cancers. Understanding the mechanisms underlying such resistance is therefore crucial for the development of new, efficacious drugs against cancer. Unfortunately in spite of extensive inquiry in this field, little is known about the key molecules and signaling pathways that regulate this phenomenon. Recently, we have discovered that microRNAs (miRNAs) may play critical roles in mediating drug sensitivity/resistance in breast cancers. We have identified miRNAs that are differentially expressed between chemo-resistant and sensitive HER2+ breast cancer cells. Specifically, through high-throughput miRNA inhibitor library screens, we have identified miRNAs that sensitize drug-resistant breast cancer cells to paclitaxel and trastuzumab, a drug combination commonly used for the treatment of metastatic HER2+ breast cancers. MiRNA/s that alter/s the cellular response to these drugs may target a common signaling pathway. For example, resistance to paclitaxel/trastuzumab in breast cancer has been proposed to be a consequence of loss of PTEN expression, leading to altered AKT signaling. Our findings suggest that certain miRNAs are selectively cytotoxic in a drug-specific manner and that these miRNAs may provide novel adjuvant therapeutic tools for the treatment of drug-resistant metastatic breast cancers. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 103rd Annual Meeting of the American Association for Cancer Research; 2012 Mar 31-Apr 4; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2012;72(8 Suppl):Abstract nr LB-481. doi:1538-7445.AM2012-LB-481
Perfect Restoration of the Shaft of the Ulna after its Complete Necrosis and Exfoliation
Authors: A. W. Stocks
Journal: BMJ (1877)

afforded to him by the batb.In ten minutes, he was joking with his friends, and enjoying himself thoroughly.The water in the bath was so conitinuously heated by the body of the patient, that it was with difficulty lowered to 70 deg.and to 6o deg.by constant baling out.With the recovery of the patient's consciousness, the use of the ther- mometer in the mouth became possible, and it was found that the upward movement of the temperature had been arrested.In this bath, cold affusions being poured continuously over the head and shoulders, the patient remained for forty-five minutes, when the thermometer had fallen slowly to I01.5 -leg.He was still very comfortable and had no chill.He was now removed to bed, placed in a warm dry blanket, and a bottle put to his feet.His aspect and manner had for some time been perfectly natural, and his pulse and respirations were scarcely ex- cessive.During the few hours which followed the bath, the temperature slowly fell to the normal.From this time forward, recovery was steady, and may have been aided by a few liberal doses of quinine, given with a view of preventing any renewal of the fever.It is but fair to add that the efforts of the medical men were admirably seconded by a nurse from the Bradford Institution, upon whom much necessarily devolved, and who carefully watched and recorded the temperatures throughout.
Changes in the law on abortion.
Authors: M H Hall
Journal: BMJ (1990)

In light of liberalized abortion legislation, the author considers the potential for increased 3rd-trimester abortion rates in England. The paper refers specifically to the Human Fertilization and Embryology Bill passed by the House of Lords on October 18, 1990. The Bill allows abortion during the 1st 24 weeks of pregnancy if risk is posed to the mother or existing children's physical or mental health. The 24-week limit is not, however, applicable when the mother is a risk of grave permanent injury or death, or in the case of substantial risk of serious handicap in the child. 3rd-trimester abortion rates will not change in the former cases, while the latter involve more complex ethics and decision-making on the part of the mother and obstetrician. While screening for malformation should provide relatively definite diagnoses within 24 weeks, some structural abnormalities may only be discovered incidentally much later in term. Incurable, yet not necessarily lethal conditions such as osteochondrodysplasias, central nervous system malformation, inborn errors of metabolism, and chromosomal anomalies may present intervention dilemmas, yet remain legal grounds for abortion within the 24-week period at the wish of the mother. 3rd-trimester abortion, however, demands consideration of the expected severity of physical and mental impairment,the child's life expectation, gestation at diagnosis, the mother's obstetric history, and that active steps such as intra-cardiac injection will be needed to kill the fetus. The pediatrician, geneticist, or surgeon are recommended for inclusion in counseling. Finally, comparing England's 1989 experience with 3rd- trimester abortions to Scotland's, where restrictive legislation has not been in effect, abortion law liberalization is not expected to extensively increase the number of late terminations.
ST-Segment Analysis Using Wireless Technology in Acute Myocardial Infarction (STAT-MI) Trial
Authors: Vivek N. Dhruva, Samir I. Abdelhadi, Ather Anis, William Gluckman, David Hom, William Dougan, Edo Kaluski, Bunyad Haider, Marc Klapholz
Journal: Journal of the American College of Cardiology (2007)
Book: Iconoclast: Abraham Flexner and a Life in Learning
Authors: E. Peile
Journal: BMJ (2002)

Thomas Neville Bonner Johns Hopkins University Press, $36, pp 400 0801871247 To order see www.jhupbooks.com ——————— Rating: ![Graphic][1]</img>![Graphic][2]</img>![Graphic][3]</img>![Graphic][4]</img> There have been few famous medical educators since Hippocrates, but Abraham Flexner is probably the best known of the last century. “It was he who defined what a medical school should and should not be,” claims Thomas Bonner in this, the first full biography of a remarkable man. Flexner was modest. For all that he rubbed shoulders with the Carnegies and the Rockefellers, brought Albert Einstein to America, and worked with the intellectual giants of education and medicine, Flexner was not caught up in the world of heroes-on-pedestals. He was, as Thomas Bonner recognises, a true iconoclast in believing that the reputations of men, institutions, and ideologies were there to … [1]: /embed/inline-graphic-1.gif [2]: /embed/inline-graphic-2.gif [3]: /embed/inline-graphic-3.gif [4]: /embed/inline-graphic-4.gif
SERUM MAGNESIUM IN THYROID DISEASE
Authors: Robert F. Dine, Paul H. Lavietes
Journal: Journal of Clinical Investigation (1942)

Serum magnesium, like serum calcium, is only partly ultrafiltrable (1).Soffer and his associates, in 1939, reported a consistent increase in the non-ultrafiltrable magnesium of the serum in hy- perthyroidism (2).In striking contrast, all of the magnesium of the serum was ultrafiltrable in two patients with myxedema.The present work confirms and extends Soffer's observations.EXPERIMENTAL PROCEDURES Blood was drawn, with anaerobic precautions, from subjects in the post-absorptive state.Ultrafiltrate was obtained from the serum by an anaerobic technique, by means of the capsule of Lavietes (3), modified in that the diameter of the effective membrane surface was in- creased to 3 cm., the cellophane membranes were dried immediately before using by pressing between smooth filter papers, and the filtration pressure was reduced to 28 cm. of mercury.More than 3 cc. of ultrafiltrate were obtained from approximately 10 cc. of serum, in 8 to 10 hours.One cc.aliquots of serum and ultrafiltrate were deliv- ered into 30 cc. porcelain evaporating dishes.To the ultrafiltrate, 2 drops of saturated sucrose solution were added to prevent subsequent loss by crepitation during ashing.With this exception, serum and ultrafiltrate were treated alike.After adding 1 cc. of 4 N H,SO4 to each dish, the dishes were placed on a steam bath for at least 2 or 3 hours, to effect charring.Ashing was accom- plished in an electric furnace at 500 to 6000 C.The ash was transferred quantitatively to a 6 cc.volu- metric flask as follows.One drop of 4 N H2SO4 was rubbed into the ash with a short rounded stirring rod, 1 cc. of water was added with further mixing, and transfer was made into the volumetric flask, facilitated by using petrolatum on the lip of the dish.This was followed by 4 washings with 0.5 cc.water.Three drops of 0.1 per cent brom-cresol green were added to the last washing to detect the presence of acid.An additional washing was used if the indicator was not blue or green.If the necks of the volumetric flasks are 6 mm. in inside diameter, the transfer may be made without the use of a funnel.To the flask was added 1 cc. of a saturated solution of ammonium oxalate, and dilute NH,OH sufficient to
IRF-1 responsiveness to immune cytokines predicts different cancer phenotypes
Authors: Daniela Murtas, Dragan Maric, Valeria De Giorgi, Jennifer Reinboth, Andrea Worschech, Patricia Fetsch, Armando Filie, Maria Ascierto, Davide Bedognetti, Qiuzhen Liu, Lorenzo Uccellini, Lotfi Chouchane, Ena Wang, Francesco M Marincola, Sara Tomei
Journal: Journal for ImmunoTherapy of Cancer (2013)

Meeting abstracts A dichotomy between immunologically active and quiescent cancer phenotypes has been demonstrated for several types of cancer. Central to such dichotomy is the master regulator of the acute inflammatory process interferon regulatory factor (IRF)-1. Although the relevance of IRF-1
Predictors of side effects during the buildup phase of venom immunotherapy for Hymenoptera venom allergy: The importance of baseline serum tryptase†
Authors: Franziska Ruëff, Bernhard Przybilla, Maria Beatrice Biló, Ulrich Müller, Fabian Scheipl, Werner Aberer, Joëlle Birnbaum, Anna Bodzenta-Lukaszyk, Floriano Bonifazi, Christoph Bucher, Paolo Campi, Ulf Darsow, Cornelia Egger, Gabrielle Haeberli, Thomas Hawranek, Iwona Kucharewicz, Helmut Küchenhoff, Roland Lang, Oliviero Quercia, Norbert Reider, Maurizio Severino, Michael Sticherling, Gunter Johannes Sturm, Brunello Wüthrich
Journal: Journal of Allergy and Clinical Immunology (2010)
Autoimmune hepatitis and its variant syndromes
Authors: Z BEN-ARI
Journal: Gut (2001)

Autoimmune hepatitis and its variant syndromesAutoimmune hepatitis (AIH) is characterised by female predominance, interface hepatitis, hypergammaglobulinaemia, and autoantibodies. 1 2Typically, the disease responds well to corticosteroid therapy, and clinical, laboratory, and histological remission can be achieved in 65% of patients within 18 months. 3 4Among Caucasoid Northern Europeans, its mean annual incidence is 1.9 per 100 000, and its point prevalence is 16.9 per 100 000. 5 In the USA, AIH aVects 100 000-200 000 individuals. 6 It accounts for 2.6% of the liver transplants in the European Liver Transplant Registry 7 and 5.9% of liver transplants in the USA. 8 Classical autoimmune hepatitisThree types of AIH have been proposed based on immunoserological findings but only two types have mutually exclusive autoantibodies and diVerent clinical profiles. 9Type 1 AIH is the most common form of the disease worldwide and is associated with antinuclear antibodies (ANA) and/or smooth muscle antibodies (SMA).It aVects all age groups and is associated with human leucocyte antigen (HLA) DR3 (DRB1*0301) and DR4 (DRB1*0401) in Caucasoid Northern European and North American patients. 10 11DRB1*0301 and DRB1*0401 influence disease expression and behaviour as well as susceptibility.Caucasoid patients with type 1 AIH and DRB1*0301 are younger, and have a higher frequency of treatment failure, 12 relapse after drug withdrawal, 13 and requirement for liver transplantation than patients with other alleles. 14In contrast, patients with DRB1*0401 are typically older, frequently have concurrent autoimmune diseases, and respond better to corticosteroids than counterparts with DRB1*0301. 15ype 2 AIH aVects mainly children and is characterised by antibodies to liver/kidney microsome type 1 (anti-LKM1). 16The target autoantigen of type 2 AIH is the cytochrome mono-oxygenase P450 IID6 (CYP2D6), 17 18 and five antigenic sites located between peptides 193-212, 257-269, 321-351, 373-389, and 410-429 are recognised by anti-LKM1. 19 20 The main antigenic site is the peptide sequence 257-269 and the second most recognised sequence is 321-351.Most patients with type 2 AIH have anti-LKM1 that react against one of these short linear sequences, 19 20 and this reactivity distinguishes them from those patients with anti-LKM1 and chronic hepatitis C. 21 22 Susceptibility to type 2 AIH appears to relate to DRB1*0701, 23 24 but HLA B14, DR3, and C4A-QO have also been incriminated. 25Immune diseases (especially vitiligo, autoimmune thyroiditis, and insulin dependent diabetes mellitus) and organ specific autoantibodies (antibodies to thyroid, parietal cell, and/or islets of Langerhans) occur commonly. 16Initial studies that suggested a poorer outcome in type 2 than in type 1 AIH 16 have not been substantiated, and both type 1 and type 2 disease respond comparably to corticosteroids. 26 272][33] This syndrome is caused by a single gene mutation located on chromosome 21q22.3. 34 35 The APS1 gene encodes for a transcription
The rate of corneocyte formation in microscopic lesions in patients with active psoriasis
Authors: ANDERS JOHANNESSON, HANS HAMMAR
Journal: British Journal of Dermatology (1981)

SUMMARY Microscopic lesions in active psoriasis were identified after careful examination with a magnifying glass in areas free of macroscopic lesions and of hair follicles. Biopsies were excised without anesthesia, immediately frozen and cryostat-sectioned. Care was taken to preserve the horny layer which was stained to reveal corneocyte membranes and nuclei when present. The interlocking sheets of corneocyte layers made it feasible to outline and trace intercellular spaces parallel to the surface and count the number of corneocyte layers between pairs of these. It was assumed that the location of such a space in the horny layer indicates the period of time from its formation. This information was used to assess the rate of corneocyte layer formation at specified intervals of time. The result shows that adjacent areas of the horny layer could be compared and relative rates of corneocyte layer formation computed. In the parakeratotic part of the early lesions of psoriasis studied the rate of corneocyte layer formation was 15 times higher than that in the non-involved skin. The peak rate, coincident with parakeratosisj was preceded by a number of thickened corneocyte layers. These also showed an increased rate of formation, up to 6.6 times that in non-involved skin. There was no acanthosis in the lesions studied. A subepidermal cellular infiltrate was observed. Periods of rapid corneocyte formation with parakeratosis were often short (not more than one day). These were interrupted by periods with a lower rate. The relationship between corneocyte morphology and stratum corneum kinetics is a distinct feature in the early psoriatic lesion.
Wants to Arrest "Patent Medicine" Man.
Authors: George C. Hafford
Journal: JAMA (1906)

Albion, Mich., Aug. 20, 1906. <h3>To the Editor:</h3> —I want information of one W. Thompson, "the oil man." He was arrested here for practicing medicine without a license, gave bail for appearance at hearing, and did not appear. He has since been in Ypsilanti, Mich., and Findlay, Ohio, and was last heard from in Windsor, Ont. He travels with four comedians, sells from a wagon, and is a very smooth talker, of dark complexion, straight black hair, rather below medium height, about 40 years of age. He sells a soap, a blood medicine, and "Egyptian Oilio" (which is said to be colored gasoline), claims to represent a quarter-million dollar company, and has five diplomas. The sheriff is prepared to get him anywhere in the United States. If some physician who believes in protecting the public from swindling impostors will wire me on his appearance in any town we will be
Xenoestrogens released from lacquer coatings in food cans.
Authors: J A Brotons, M F Olea-Serrano, M Villalobos, V Pedraza, N Olea
Journal: Environmental Health Perspectives (1995)

We present data showing that some foods preserved in lacquer-coated cans and the liquid in them may acquire estrogenic activity. Hormonal activity was measured using the E-screen bioassay. The biological activity of vegetables packed in cans was a result of plastic monomers used in manufacturing the containers. The plastic monomer bisphenol-A, identified by mass spectrometry, was found as a contaminant not only in the liquid of the preserved vegetables but also in water autoclaved in the cans. The amount of bisphenol-A in the extracts accounted for all the hormonal activity measured. Although the presence of other xenoestrogens cannot be ruled out, it is apparent that all estrogenic activity in these cans was due to bisphenol-A leached from the lacquer coating. The use of plastic in food-packaging materials may require closer scrutiny to determine whether epoxy resins and polycarbonates contribute to human exposure to xenoestrogens.
Neonatal Abstinence Syndrome
Authors: Hendree E. Jones, Karol Kaltenbach
Journal: JAMA (2012)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Familial Occurrence of Abdominal Aortic Aneurysm
Authors: Jarmo A. Salo
Journal: Annals of Internal Medicine (1999)

Background: A family history of abdominal aortic aneurysm has been reported to increase the risk for developing the disease. Objective: To determine the risk for abdominal aortic aneurysm in first-degree relatives of patients with the disease. Design: Cross-sectional ultrasonographic screening study. Setting: University Central Hospital, Helsinki, Finland. Patients: 238 of 325 living first-degree relatives of patients having surgery for abdominal aortic aneurysm (age > 50 years; 98 men and 110 women) and 281 controls (135 men and 149 women) without a family history of abdominal aortic aneurysm. Measurements: Ultrasonography was used to measure aortic diameter in 101 male relatives and 140 female relatives (241 of the 325 persons at risk [74%]) and in 281 controls. Results: Three siblings had already undergone surgery for abdominal aortic aneurysm. Eleven siblings (all brothers) (11 of 101 [10.9%]) had ultrasonographic evidence of abdominal aortic aneurysm (aortic diameter > 30 mm). In the control group, 2 men (1.5%) and 2 women (1.3%) had an aneurysm. Thirty siblings and no controls had dilatation of the abdominal aorta (aortic diameter, 20 to 29 mm). Neither the age nor the sex of the proband affected risk for developing abdominal aortic aneurysm among first-degree relatives. Family history increased the risk for an aneurysm by 4.33-fold (95% CI, 1.32-fold to 14.23-fold), male sex increased the risk by 12.21-fold (CI, 2.63-fold to 56.64-fold), and age (by decade) increased the risk by 1.93-fold (CI, 1.15-fold to 3.25-fold). Conclusion: Aging brothers of patients with known abdominal aortic aneurysm have the highest risk for developing the disease; the prevalence of the disease in siblings older than 60 years of age is 18%.
Lead Poisoning with Bladder Colic and Amblyopia
Authors: Perk Lee Davis
Journal: JAMA (1961)

<h3>To the Editor:—</h3> A case of lead poisoning with unusual manifestations is considered worthy of record because of two unusual signs and symptoms seldom noted in previous reports or texts on the subject. The dominant one was extreme perineal and retropubic pressure and retropubic pain. The other symptom was severe amblyopia without evidences of any changes in the fundus or signs of optic neuritis. The patient was a 43-year-old man who owned three gas stations and worked in one of them. His complaints were so severe that a cystoscopy and proctosigmoidoscopy were performed and revealed negative findings. The fundus and fields showed negative results. There was a blue line on the gums. The results of the remainder of the physical and neurologic examinations were negative. The hemoglobin level was 11.6 Gm., and the erythrocytes numbered 3,490,000 per cubic millimeter. The blood smear revealed many stippled red cells, and an examination
A 60% oxygen supply for medical use
Authors: J. E. Cotes, A. G. Douglas-Jones, M. J. Saunders
Journal: BMJ (1969)

A supply of 60% oxygen with 40% nitrogen should be acceptable for most clinical purposes, since usually only low dosages of oxygen are required. The gas may be provided by means of an oxygen concentrator (Rimer-Birlec), which is a compact, transportable, electrically operated apparatus capable of providing 28 l./min. (1 cu. ft./min.) of 60% oxygen from a source of compressed air. The biological effect of the gas from the device is the same as that of 60% oxygen from a conventional source. Measurements of inspired oxygen concentration show that the 60% oxygen may be used with present-day oxygen masks to provide inspired oxygen concentrations in the range 25 to 40%; for higher inspired concentrations alternative equipment is likely to be required. The concentrator appears to be a practical source of oxygen for expeditions and out-of-the-way places. It may provide an economical supply for a ward block, and with further development should be a convenient source of 30% oxygen for domiciliary use.
Panel defends India's traditional doctors
Authors: G. Mudur
Journal: BMJ (1997)

Recent attempts to prevent doctors of traditional medicine in India from prescribing modern drugs will mean denying appropriate and timely treatment to millions of patients across the country, a panel of experts has said. The panel urged the Indian government to allow traditional doctors to continue to prescribe certain essential drugs to patients.

The panel, which included traditional doctors-as well as doctors of modern medicine, representatives of the traditional drugs industry, …
Magnetic Resonance Imaging Versus Computed Tomography of Leukocoric Eyes and Use of In Vitro Proton Magnetic Resonance Spectroscopy of Retinoblastoma
Authors: Mahmood F. Mafee, Morton F. Goldberg, Steven B. Cohen, Efstathios D. Gotsis, Marc Safran, Lavanya Chekuri, Bahram Raofi
Journal: Ophthalmology (1989)