STUDIES IN RHEUMATIC FEVER II. ABSORPTION OF SALICYLATES
Authors: Robert W. Huntington, Rosalie D. Ryan, Hugh R. Butt, George C. Griffith, Hugh Montgomery, Robert F. Solley, William H. Leake
Journal: Annals of Internal Medicine (1946)

Article1 June 1946STUDIES IN RHEUMATIC FEVER II. ABSORPTION OF SALICYLATESROBERT W. HUNTINGTON JR., ROSALIE D. RYAN, HUGH R. BUTT, GEORGE C. GRIFFITH, HUGH MONTGOMERY, ROBERT F. SOLLEY, WILLIAM H. LEAKEROBERT W. HUNTINGTON JR.Search for more papers by this author, ROSALIE D. RYANSearch for more papers by this author, HUGH R. BUTTSearch for more papers by this author, GEORGE C. GRIFFITHSearch for more papers by this author, HUGH MONTGOMERYSearch for more papers by this author, ROBERT F. SOLLEYSearch for more papers by this author, WILLIAM H. LEAKESearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-24-6-1029 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptINTRODUCTIONAlthough salicylates induce striking symptomatic relief in rheumatic fever, especially in the presence of polyarthritis, the question of a more radical therapeutic action is a debated one. It has recently been suggested1 that while small doses produce symptomatic relief only, large doses have a genuine curative effect. Our own data on this problem are analyzed in detail elsewhere.2 The present paper is concerned with the technic of reaching the plasma or serum salicylate level of 20 to 30 mg. per cent or higher, which Coburn considered critical.We have studied serum salicylate levels following oral, rectal and intravenous administration...Bibliography1. COBURN AF: Salicylate therapy in rheumatic fever, Bull. Johns Hopkins Hosp., 1943, lxxiii, 435. Google Scholar2. GRIFFITH GC: Treatment of rheumatic fever, Mod. Concepts, 1945, xiv, June and July. Google Scholar3. SMULLWEGRIACLOUD KRJ: The effect of sodium bicarbonate on the serum salicylate level, Jr. Am. Med Assoc., 1944, cxxv, 1173. CrossrefGoogle Scholar4. BRODIEUDENFRIEDCOBURN BBSAF: The determination of salicylic acid in plasma, Jr. Pharm. and Exper. Therap., 1944, lxxx, 114. Google Scholar5. BUTT HR: Studies in rheumatic fever. I. The effect of salicylate on the prothrombin time and upon the hepatic parenchyma, Jr. Am. Med. Assoc., 1945, cxxviii, 1195. CrossrefGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: *Received for publication November 14, 1945.From the Laboratory and the Rheumatic Fever Service United States Naval Hospital, Corona, California. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byRHEUMATISM AND ARTHRITIS REVIEW OF AMERICAN AND ENGLISH LITERATURE OF RECENT YEARS (TENTH RHEUMATISM REVIEW)* Part IIWILLIAM D. ROBINSON, M.D., F.A.C.P., EDWARD W. BOLAND, M.D., F.A.C.P., JOSEPH J. BUNIM, M.D., F.A.C.P., DARRELL C. CRAIN, M.D., F.A.C.P., EPHRAIM P. ENGLEMAN, M.D., F.A.C.P., WALLACE GRAHAM, M.D., F.R.C.P. (C), L. MAXWELL LOCKIE, M.D., F.A.C.P., MAX M. MONTGOMERY, M.D., F.A.C.P., CHARLES RAGAN, M.D., F.A.C.P., MARIAN W. ROPES, M.D., F.A.C.P., EDWARD F. ROSENBERG, M.D., F.A.C.P., CHARLEY J. SMYTH, M.D.Treatment of acute rheumatic fever with aspirinThe Necessity and Possibility of giving Detoxified Large Oral Doses of Salicylates in the Treatment of Rheumatic Fever in Order to Prevent or Cure the Inflammatory Stage of CarditisEasy and Accurate Method for Determination of Serum- and Urine-Salicyl-Levels during Treatment with Salicyl-Drugs 1 June 1946Volume 24, Issue 6Page: 1029-1038KeywordsArthritisBlood plasmaHyperthermiaResearch laboratoriesRheumatic feverSalicylates ePublished: 1 December 2008 Issue Published: 1 June 1946 PDF downloadLoading ...