tbuckley/cabot-search huggingface dataset:
Model-Dependent Effects of the Gap Junction Conduction–Enhancing Antiarrhythmic Peptide Rotigaptide (ZP123) on Experimental Atrial Fibrillation in Dogs
Authors: Akiko Shiroshita-Takeshita, Masao Sakabe, Ketil Haugan, James K. Hennan, Stanley Nattel
Journal: Circulation (2007)

Abnormal intercellular communication caused by connexin dysfunction may be involved in atrial fibrillation (AF). The present study assessed the effect of the gap junctional conduction-enhancing peptide rotigaptide on AF maintenance in substrates that result from congestive heart failure induced by 2-week ventricular tachypacing (240 bpm), atrial tachypacing (ATP; 400 bpm for 3 to 6 weeks), and isolated atrial myocardial ischemia.Electrophysiological study and epicardial mapping were performed before and after rotigaptide administration in dogs with ATP and congestive heart failure, as well as in similarly instrumented sham dogs that were not tachypaced. For atrial myocardial ischemia, dogs administered rotigaptide before myocardial ischemia were compared with no-drug myocardial ischemia controls. ATP significantly shortened the atrial effective refractory period (P=0.003) and increased AF duration (P=0.008), with AF lasting >3 hours in all 6-week ATP animals. Rotigaptide increased conduction velocity in ATP dogs slightly but significantly (P=0.04) and did not affect the effective refractory period, AF duration, or atrial vulnerability. In dogs with congestive heart failure, rotigaptide also slightly increased conduction velocity (P=0.046) but failed to prevent AF promotion. Rotigaptide had no statistically significant effects in sham dogs. Myocardial ischemia alone increased AF duration and impaired conduction (based on conduction velocity across the ischemic border and indices of conduction heterogeneity). Rotigaptide prevented myocardial ischemia-induced conduction slowing and AF duration increases.Rotigaptide improves conduction in various AF models but suppresses AF only for the acute ischemia substrate. These results define the atrial antiarrhythmic profile of a mechanistically novel antiarrhythmic drug and suggest that gap junction dysfunction may be more important in ischemic AF than in ATP remodeling or congestive heart failure substrates.
Somatic mutations of JAK2 exon 12 in patients with JAK2 (V617F)-negative myeloproliferative disorders
Authors: Daniela Pietra, Sai Li, Angela Brisci, Francesco Passamonti, Elisa Rumi, Alexandre Theocharides, Maurizio Ferrari, Heinz Gisslinger, Robert Kralovics, Laura Cremonesi, Radek Skoda, Mario Cazzola
Journal: Blood (2007)
The urokinase plasminogen activator receptor (uPAR) controls macrophage phagocytosis in intestinal inflammation
Authors: Marco Genua, Silvia D'Alessio, Javier Cibella, Alessandro Gandelli, Emanuela Sala, Carmen Correale, Antonino Spinelli, Vincenzo Arena, Alberto Malesci, Sergio Rutella, Victoria A Ploplis, Stefania Vetrano, Silvio Danese
Journal: Gut (2014)

Inflammation plays crucial roles in the pathogenesis of several chronic inflammatory disorders, including Crohn's disease (CD) and UC, the two major forms of IBD. The urokinase plasminogen activator receptor (uPAR) exerts pleiotropic functions over the course of both physiological and pathological processes. uPAR not only has a key role in fibrinolysis but also modulates the development of protective immunity. Additionally, uPAR supports extracellular matrix degradation and regulates cell migration, adhesion and proliferation, thus influencing the development of inflammatory and immune responses. This study aimed to evaluate the role of uPAR in the pathogenesis of IBD.The functional role of uPAR was assessed in established experimental models of colitis. uPAR deficiency effects on cytokine release, polarisation and bacterial phagocytosis were analysed in colonic macrophages. uPAR expression was analysed in surgical specimens collected from normal subjects and patients with IBD.In mice, uPAR expression is positively regulated as colitis progresses. uPAR-KO mice displayed severe inflammation compared with wild-type littermates, as indicated by clinical assessment, endoscopy and colon histology. The absence of uPAR led to an increased production of inflammatory cytokines by macrophages that showed an M1 polarisation and impaired phagocytosis. In human IBD, CD68(+) macrophages derived from the inflamed mucosa expressed low levels of uPAR.These findings point to uPAR as an essential component of intestinal macrophage functions and unravel a new potential target to control mucosal inflammation in IBD.
Atomic Bomb Survivor Data: Utilization and Analysis
Authors: Glyn G. Caldwell
Journal: JAMA (1986)

This volume is a collection of 18 papers divided into six sections, including a brief introduction to each section. The stated purpose of the series and this volume is to probe the ability of statistical and mathematical analyses to explain complex societal problems. The data presented describe the various study populations of Hiroshima and Nagasaki survivors developed and augmented by the Atomic Bomb Casualty Commission (ABCC) and by its successor, the Radiation Effects Research Foundation (RERF). The papers outline the epidemiologic and statistical methods used to analyze and interpret the follow-up data. The first section updates the data collected and maintained in the major cohort studies, the Life Span Study (LSS) and the Adult Health Study (AHS). These groups include data about 109 000 and 20 000 persons, respectively. The LSS includes 82 000 survivors first identified in 1950 and 27 000 unexposed persons. The AHS study provides data from
Low-dose ARAC, donor cells, and GM-CSF for treatment of recurrent acute myeloid leukemia after allogeneic stem cell transplantation
Authors: C Schmid, M Schleuning, J Aschan, O Ringdén, J Hahn, E Holler, U Hegenbart, D Niederwieser, M Dugas, G Ledderose, H-J Kolb
Journal: Leukemia (2004)
Non-medical staff play key role in healthcare access for uninsured patients
Authors: David Spurgeon
Journal: BMJ (2004)

Non-medical staff play a major role in decisions affecting access to care for uninsured patients in clinics in the United States and in the admissions areas of three large urban medical centres, a new study shows ( Medical Care 2004;42:306-12). But they are also ambivalent about dealing with a system that discourages care for people without insurance, it adds.

Dr Saul Weiner, of the department of medicine at the University of Illinois, Chicago, and colleagues write that each year many of the more than 40 million Americans without health care insurance seek routine (non-emergency) services they cannot afford, but most providers …
Respiratory muscle and cardiopulmonary function during exercise in very severe COPD.
Authors: M Montes de Oca, J Rassulo, B R Celli
Journal: American Journal of Respiratory and Critical Care Medicine (1996)

Chronic obstructive pulmonary disease (COPD) is thought to limit exercise capacity through a decreased ventilatory reserve, with cardiovascular factors playing a minimal role. We assessed respiratory muscle (RM) and cardiopulmonary function during exercise in very severe COPD (FEV1 0.79 +/- 0.17 L). We determined minute ventilation (VE), oxygen consumption (VO2), carbon dioxide production (VCO2), heart rate (HR), respiratory rate (RR), and O2 pulse with a metabolic cart. RM function was assessed from esophageal and gastric pressures. Dyspnea was assessed with a visual analog scale (VAS). Exercise capacity (peak VO2 = 36 +/- 31%), ventilatory reserve (VE/maximum voluntary ventilation [MW] = 89 +/- 31%), HR = 76 +/- 15%, and O2 pulse (O2Pmax = 45 +/- 15%) were abnormal. Peak VO2 correlated with O2Pmax(r = 0.82), the change in end-inspiratory pleural pressure (deltaPpli) (r = -0.74), maximal transdiaphragmatic pressure (Pdimax) (r = 0.68), and VEmax (r = 0.58). There were similar correlations with exercise endurance time. Multiple regression analysis revealed O2Pmax to be the best predictor of peak VO2. Thereafter, only VEmax and deltaPpli remained significant (r2 = 0.87). O2Pmax correlated with inspiratory muscle function (Pplimax, r = -0.58; Pdimax, r = 0.53; deltaPpli, r = -0.47; and PImax, r = -0.47). By multiple regression analysis, the predictors of O2Pmax were Pplimax and deltaPpli (r2 = 0.47). In very severe COPD, the impressive swings in intrathoracic pressure resulting from deranged ventilatory mechanics are the most likely cause of exercise limitation and reduced O2 pulse. The contributions of factors such as deconditioning, hypoxemia, and concurrent heart disease remain unknown.
The Calabar Bean Paper, and its Effects upon the Pupil of the Eye
Authors: J. W. Ogle
Journal: BMJ (1863)

no indication (except the extemal marks) of the former long continued disease.The young man was employed in cultivating the ground attacbed to the union house for several months after he was cured; and has since been employed regu-* Under this lhead, we may refer to the very words of the Charter of 1852.We there read: "That the Pr?esident anjd
Oral Anticoagulants and the Risk of Intracranial Hemorrhage
Authors: Paul M. Vespa
Journal: JAMA (2014)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The ranibizumab saga of drug profiteering
Authors: A. C K Lee, J. Radford
Journal: BMJ (2008)

The National Institute for Health and Clinical Excellence (NICE) recently sanctioned the use of ranibizumab for age related macular degeneration, having originally concluded it would be cost effective only if limited to treating one eye, which could jeopardise functional vision.1 2 The exorbitant price …
De Novo induction and recruitment of allergen-specific effector CD8+ T cells in a mouse model of IgE-mediated allergy and airway inflammation
Authors: J.A. Aguilar Piementel, K. Huster, F. Alessandrini, J. Gutermuth, T. Jakob, H. Behrendt, J. Ring, D. Busch, M. Mempel, M. Ollert
Journal: Journal of Allergy and Clinical Immunology (2005)
ETV6/RUNX1-positive relapses evolve from an ancestral clone and frequently acquire deletions of genes implicated in glucocorticoid signaling
Authors: Lilian Kuster, Reinhard Grausenburger, Gerhard Fuka, Ulrike Kaindl, Gerd Krapf, Andrea Inthal, Georg Mann, Maximilian Kauer, Johannes Rainer, Reinhard Kofler, Andrew Hall, Markus Metzler, Lüder Hinrich Meyer, Claus Meyer, Jochen Harbott, Rolf Marschalek, Sabine Strehl, Oskar A. Haas, Renate Panzer-Grümayer
Journal: Blood (2011)
Impact of Intracoronary Cell Therapy on Left Ventricular Function in the Setting of Acute Myocardial Infarction
Authors: Michael J. Lipinski, Giuseppe G.L. Biondi-Zoccai, Antonio Abbate, Reena Khianey, Imad Sheiban, Jozef Bartunek, Marc Vanderheyden, Hyo-Soo Kim, Hyun-Jae Kang, Bodo E. Strauer, George W. Vetrovec
Journal: Journal of the American College of Cardiology (2007)
Pneumatosis Cystoides Esophagi
Authors: Boon Vanasin
Journal: JAMA (1971)

A patient with lower esophageal stricture developed pneumatosis cystoides esophagi after many years. Proximal to the stricture air had penetrated the submucosa into the deep muscle layers, suggesting that air entering through a mucosal defect proximal to the stricture was driven into deeper layers by high pressures resulting from partial obstruction. Distal to the stricture air cysts were limited to the submucosa suggesting that air had dissected caudally by peristalsis through loose submucosal tissue to the stomach and proximal small intestine.
Correction: Prevention of Hemorrhagic Cystitis after Cyclophosphamide
Authors: Mary V. Relling
Journal: Annals of Internal Medicine (1990)

Letters and Corrections15 April 1990Correction: Prevention of Hemorrhagic Cystitis after CyclophosphamideMary V. Relling, PharmDMary V. Relling, PharmDSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-112-8-634 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the Editor:In the urologic effects section (page 418, second column, first sentence) of the review on surviving adult cancers (1), it is erroneously stated that ifosfamide may prevent the occurrence of cystitis after cyclophosphamide administration. Ifosfamide is an antineoplastic agent that is a structural isomer of cyclophosphamide. Like cyclophosphamide, it can induce hemorrhagic cystitis, presumably by the same mechanism (that is, liberation of acrolein in the bladder) (2). Cystitis induced by either of these oxazaphosphorines can be prevented by co-administration of mesna (sodium 2-mercapto-ethanesulphonate), a compound that increases free thiol concentrations in the bladder, which can bind to...References1. Loescher L, Welch-McCaffrey D, Leigh S, Hoffman B, and Meyskens F. Surviving adult cancers. Part 1: physiologic effects. Ann Intern Med. 1989;111:411-32. LinkGoogle Scholar2. Zalupski M and Baker L. Ifosfamide. J Natl Cancer Inst. 1988;80:556-66. CrossrefMedlineGoogle Scholar3. Shaw I. Mesna and oxazaphosphorine cancer chemotherapy. Cancer Treat Rev. 1987;14:359-64. CrossrefMedlineGoogle Scholar1. Scheef W, Klein H, and Brock N. Controlled clinical studies with an antidote against the urotoxicity of oxazaphosphorines: preliminary results. Cancer Treat Rep. 1979;63:501-5. MedlineGoogle Scholar2. Shaw I and Graham M. Mesna—a short review. Cancer Treat Rev. 1987;14:67-86. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: Mary V. Relling, PharmDAffiliations: St. Jude Children's Research Center Memphis, TN 38101-0318 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 15 April 1990Volume 112, Issue 8Page: 634-634KeywordsAttentionBladderCancer preventionCyclophosphamideCystitisSodium ePublished: 1 December 2008 Issue Published: 15 April 1990 PDF downloadLoading ...
New directions in primary biliary cirrhosis.
Authors: M C Bateson
Journal: BMJ (1990)

efficient to develop a single paediatric rehabilitation resource team to train and advise on head injury.The report of the working party of the Medical Disability Society on the management of traumatic brain injury virtually ignored services for children.29That omission is further evidence of the need for separate advocacy -a paediatrician in every district to develop and provide services for children with head injuries.
Concomitant occurrence of disseminated intravascular coagulation and factor VIII inhibitor in a patient with prostatic cancer
Authors: Usha Singal, Eberhard F. Mammen
Journal: American Journal of Hematology (1987)

Abstract An 86‐year‐old man, diagnosed as having carcinoma of the prostate, stage D, was admitted to the hospital. Soon after admission, he developed bleeding from various sites, including intravenous puncture sites and gastrointestinal and urinary tracts. A clinical diagnosis of disseminated intravascular coagulation (DIC) was made, which was corraborated by laboratory data. A factor VIII inhibitor of 12.5 Bethesda units was also identified in the patient's plasma. Concomitant occurrence of disseminated intravascular coagulation and an acquired factor VIII inhibitor has not been reported previously.
Dermatology in General Medicine: Textbook and Atlas
Authors: Philip C. Anderson
Journal: JAMA (1987)

One of the most reassuring discoveries to make in comparing the best modern textbooks with their ancestors of 30 years ago is that bioscience has become their foundation. The older books were only rambling clinical manuals. This fine two-volume giant dermatology book of more than 2600 pages is an encouraging exposition of the recent advancement of medicine achieved as a result of improved research. Three similar, excellent, up-to-date textbooks are available edited by US authorities for specialists in dermatology, but this one, developed since 1971 into the third edition by Dr Thomas Fitzpatrick of the Harvard Medical School and his associates, most thoroughly and consistently explains diseases utilizing new concepts from the basic sciences. Because of this wide excursion into the sciences, the Fitzpatrick book may appeal most to physicians and scientists working outside of clinical dermatology. Novices ought to know that this is not the book for beginners. Good
Improved Diagnosis of Aortobifemoral Vascular Graft Infection by In-111-Labeled Leukocyte SPECT
Authors: Pierre Abouhamad, Bruno Krug, Christian Picard, C??cile Nogar??de, Mark Seldrum, Michel Buche, Thierry Vander Borght
Journal: Clinical Nuclear Medicine (2006)

A 78-year-old man with a more than 10-year-old aortobifemoral vascular graft was referred for inguinal tumefaction suspicious of abscess. Planar whole-body In-111-labeled leukocyte scan only revealed mild increased activity in the right iliac fossa. In contrast, the SPECT study clearly demonstrated aortobifemoral prosthesis uptake extending to the left inguinal region and the right iliac fossa. A contrast-enhanced abdominal CT scan confirmed the presence of a right distal pseudoaneurysm as well as the presence of a periprosthetic collection. The inguinal abscess was drained and the aortobifemoral vascular graft was removed after ligation of the subrenal aorta. Then, an axillobifemoral vascular graft was implanted. The surgical procedure was further associated for 6 weeks with vancomycin targeted against the suspected staphylococcal pathogen with subsequent complete clinical and biologic responses. One year after this infectious event, the patient is still in complete recovery.
Swan’s Way
Authors: Arnold Blank
Journal: JAMA (2006)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Bending the Curve on Cardiovascular Risk
Authors: Stephan D. Fihn
Journal: JAMA Internal Medicine (2013)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Internal Medicine HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Internal Medicine journal
Unpublished data in drug advertisements.
Authors: D Massam
Journal: BMJ (1993)

drop out (36% with SSRI and 39% with tricyclic antidepressants; p=0-34).Both studies quoted by Hale as showing an advantage of SSRIs over tricyclic antidepressants in long term compliance were placebo controlled, not including tricyclic antidepressants.In summary, there seems little evidence to support the routine first line use of SSRIs.The debate has now shifted to the issues of suicide by overdose and costs.This cannot be resolved by reference to the trial data and will be the subject of a further paper.SmithKline Beecham and Lilly Industries Ltd refer to data from unpublished studies, which therefore cannot be commented on.The burden of proof must lie with those who advocate the use of expensive new drugs on the basis of improved tolerability.
Renal replacement treatment. CAPD has its limitations.
Authors: J E Tattersall, R N Greenwood, K Earrington
Journal: BMJ (1993)

statistical theory5 and the possibility of neatly partitioning attitudes and behaviours.The (predictable) conclusion that we need to "educate the people" on the dangers of a high fat diet plainly conflicts with a more striking feature of the results-namely, that the degree to which people thought that their behaviours were risky seems to reflect the degree of certainty among experts that change in that behaviour is beneficial.Why should the authors emphasise the need for education when experts disagreee?This paper, like others, suggests that the public may often be more sophisticated in their understanding than those who would pretend to educate them.
Pulmonary Diseases and Disorders
Authors: William R. Barclay
Journal: JAMA (1981)

The field of pulmonary diseases, like many other medical specialties, is replete with textbooks and monographs. One could fill several library shelves with books on tuberculosis, lung cancer, pulmonary function, or any other special topic. Why, then, another large tome on pulmonary diseases and disorders? I suppose the answer lies in the hope that if one writes a better book, physicians will beat a path to the bookseller. Fishman's book is certainly better than most, and as good as the best. He persuaded a distinguished group of pulmonary specialists in the United States and abroad to contribute to this two-volume work. However, Dr Fishman himself has taken on the lion's share of the writing and obviously has been editor in more than just title. The text is extremely well edited, and the reader does not encounter the grossly uneven style that plagues so many works by multiple authors. The illustrations
1106-188 Ghrelin is synthesized and secreted by human cardiomyocytes protecting these cells from apoptosis
Authors: JoséRamón González-Juanatey, María J Iglesias, Roberto Piñeiro, Oreste Gualillo, Montserrat Blanco, Carlos Diéguez, Francisca Lago
Journal: Journal of the American College of Cardiology (2004)