tbuckley/cabot-search huggingface dataset:
Abstract 2993: Dll4 inhibition plus aflibercept markedly reduces ovarian tumor burden and ascites
Authors: Jie Huang, Wei Hu, Heather J. Dalton, Justin Bottsford-Miller, Robert L. Coleman, Robert B. Jaffe, Anil K. Sood
Journal: Cancer Research (2014)

Abstract Purpose: To determine the effects of Dll4 blockade with and without aflibercept on ovarian tumor burden and ascites in preclinical models. Methods: Using Dll4-Fc and anti-Dll4 antibodies, we evaluated the biological effects of Dll4 inhibition combined with aflibercept in vivo (orthotopic mouse models of ovarian cancer). Reverse phase protein array (RPPA) analysis was used to identify potential biomarkers of treatment response. Results: To address the biological significance of Dll4 expression in tumor cells versus endothelial cells, we used human and mouse anti-Dll4 antibodies in vivo. In the A2780 model, treatment with mouse (REGN1035) or human (REGN421) anti-Dll4 antibodies reduced tumor weight by 61.5% and 82.4%, respectively, compared to the controls (P &amp;lt; 0.05 for both). Aflibercept alone reduced tumor weight by 90% (p &amp;lt; 0.05). The combinations of REGN1035 plus aflibercept, and REGN421 plus aflibercept resulted in the greatest inhibition of tumor growth, reducing respective tumor weight by 95.8% and 93.9%, compared to the controls (P &amp;lt; 0.05). The anti-tumor effects were related to decreased angiogenesis and increased apoptosis. RPPA analysis revealed that caspase3 and GATA3 were significantly increased; cyclin D1, Bcl-2 and pS6-s240_s244 were decreased in response to Dll4 Inhibition plus aflibercept. Among these, GATA3, a transcription factor for E-cadherin, was significantly induced by Dll4 Inhibition plus aflibercept, resulting in the up-regulation of E-cadherin expression in human cancer cells. Furthermore, GATA3 and E-cadherin expression might be useful as potential biomarkers of response. Conclusions: Dual targeting of Dll4 and VEGF shows promise for inhibiting ovarian tumor growth and may have important clinical implications. Citation Format: Jie Huang, Wei Hu, Heather J. Dalton, Justin Bottsford-Miller, Robert L. Coleman, Robert B. Jaffe, Anil K. Sood. Dll4 inhibition plus aflibercept markedly reduces ovarian tumor burden and ascites. [abstract]. In: Proceedings of the 105th Annual Meeting of the American Association for Cancer Research; 2014 Apr 5-9; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2014;74(19 Suppl):Abstract nr 2993. doi:10.1158/1538-7445.AM2014-2993
Clinical implications of minimal residual disease monitoring by quantitative polymerase chain reaction in acute myeloid leukemia patients bearing nucleophosmin (NPM1) mutations
Authors: W-C Chou, J-L Tang, S-J Wu, W Tsay, M Yao, S-Y Huang, K-C Huang, C-Y Chen, C-F Huang, H-F Tien
Journal: Leukemia (2007)
Abstract 3542: Analysis of miRNA mediated Cisplatin resistant mechanisms
Authors: Toshihiro Suzuki, Kazuto NIshio, Tadayasu Togawa, Kanako Sugawara, Hitoshi Sakuraba
Journal: Cancer Research (2010)

Abstract Cisplatin is an effective anticancer agent that is widely used in the treatment of testicular, ovarian, bladder and lung cancers. However, the development of resistance to cisplatin is a major obstacle to treatment. To understand the clinically relevant mechanisms of resistance, many studies have been aimed at clarifying the biochemical/molecular alterations of cisplatin-resistant cells. However, these studies did not conclusively identify the basis of cellular resistance to cisplatin. Recently some studies have shown that micro RNAs play an important role in cancer cell resistance to chemotherapeutic agents and cancer development. In this study, micro RNA expression profiles of cisplatin resistant non small cell lung cancer cell lines were analyzed using microarray and real time RT-PCR. We found some of micro RNAs were similarly regulated in couple of cisplatin resistant cell lines. These finding are useful for understanding the miRNA mediated cisplatin resistance mechanisms. Now, functional analyses on miRNAs involving cisplatin resistance are in progress. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 101st Annual Meeting of the American Association for Cancer Research; 2010 Apr 17-21; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2010;70(8 Suppl):Abstract nr 3542.
Prescription-Picking, Hindu Style
Authors: John H. Schaefer
Journal: JAMA (1964)

<h3>To the Editor:—</h3> In "Smile a While" (<i>JAMA</i><b>190</b>, Oct 5, 1964, adv p 271) under the caption "Patient Cooperation, Indian Style" is a story from Bombay, India, which reminds me of my experiences with Hindus when I was in general practice in the San Jaoquin Valley shortly after World War I. There were quite a few Hindu farm workers around and occasionally one would come into the office. Invariably the conversation started with a monotonous monologue of complaints which I could not interrupt. Even questions were ignored, and physical examinations were not allowed. On my first such encounter I wrote a harmless prescription and handed it to the patient, but that started him off on another long monologue. This went on for about 20 minutes until he had got three prescriptions. Later in the day the druggist put me wise. Two or more Hindus would get together and send
Novel Insights into Head and Neck Cancer using Next-Generation “Omic” Technologies
Authors: Lusia Sepiashvili, Jeff P. Bruce, Shao Hui Huang, Brian O'Sullivan, Fei-Fei Liu, Thomas Kislinger
Journal: Cancer Research (2015)

Abstract Head and neck squamous cell carcinoma (HNSCC) is a highly heterogeneous disease that develops via one of the two primary carcinogenic routes: chemical carcinogenesis through exposure to tobacco and alcohol or virally induced tumorigenesis. Human papillomavirus (HPV)–positive (HPV+) and HPV-negative (HPV−) HNSCCs represent distinct clinical entities, with the latter associated with significantly inferior outcome. The biologic basis of these different outcomes is an area of intense investigation; their therapeutic regimens are currently also being reevaluated, which would be significantly facilitated by reliable biomarkers for stratification. With the advent of the omics era and accelerated development of targeted therapies, there are unprecedented opportunities to address the challenges in the management of HNSCC. As summarized herein, side-by-side molecular characterization of HPV+ versus HPV− HNSCC has revealed distinct molecular landscapes, novel prognostic signatures, and potentially targetable biologic pathways. In particular, we focus on the evidence acquired from genome-wide omics pertinent to our understanding of the clinical behavior of HNSCC and on insights into personalized treatment opportunities. Integrating, mining, and validating these data toward clinically meaningful outcomes for patients with HNSCC in conjunction with systematic verification of the functional relevance of these findings are critical steps toward the design of personalized therapies. Cancer Res; 75(3); 480–6. ©2014 AACR.
Case 21-1997: Paraneoplastic Cerebellar Degeneration and Hodgkin's Disease
Authors: Tahseen Mozaffar
Journal: New England Journal of Medicine (1998)

To the Editor: Dr. Eder, in his discussion of the paraneoplastic cerebellar degeneration associated with Hodgkin's disease (July 10 issue),1 quoted the 1976 paper by Trotter and colleagues2 but did not mention that the antibodies they described are now recognized as distinct antibodies associated with Hodgkin's disease. These antibodies have been designated anti-Tr antibodies.3 They have a characteristic dotted staining pattern, suggestive of immunoreactivity of the dendritic spines of Purkinje cells, and are specific for Hodgkin's disease.
Totem Pole Sign
Authors: RICHARD P. SPENCER, DENISE M. MALCOLM, PATRICIA A. BARTON
Journal: Clinical Nuclear Medicine (1991)

A bone densitometry study in a 62-year-old woman revealed “wings” extending outward from the L-4 vertebra, creating the appearance of a totem pole. The apparent density of L-4 was about twice that of neighboring vertebrae. The patient had undergone an upper GI series (barium) 24 hours previously. On a repeat study 8 days later, the “Wings”, and totem pole appearance were gone, and the recorded L-4 density was similar to that of its neighbors.
Infectious Hepatitis
Authors: Saul Krugman, Robert Ward, Joan P. Giles, Oscar Bodansky, A. Milton Jacobs
Journal: New England Journal of Medicine (1959)

THE control of infectious hepatitis still remains one of the most perplexing problems in preventive medicine. Progress in this field has been retarded by many gaps in the knowledge of the natural history of the disease. What is the period of infectivity of infectious hepatitis? What is the role of inapparent infection in its spread? A precise answer to these and many other questions is difficult because of the lack of a specific laboratory test for the identification of the virus. Unfortunately, man is still the only established susceptible host. Efforts to adapt the agent consistently to laboratory animals or . . .
Patient Pain During Colonoscopy: An Analysis Using Real-Time Magnetic Endoscope Imaging
Authors: S. G. Shah, J. C. Brooker, C. Thapar, C. B. Williams, B. P. Saunders
Journal: Endoscopy (2002)

Background and Study Aims: Colonoscopy is generally perceived as being a painful procedure. Contributory factors are: stretching of the colonic wall and mesenteric attachments from looping of the instrument shaft, overinsufflation, the degree of torque or force applied to the colonoscope shaft, and patient pain threshold. The aim of this study was to determine the frequency of pain episodes experienced during diagnostic colonoscopy and the corresponding colonoscope configuration, utilizing real-time magnetic endoscope imaging (MEI). Patients and Methods: Consecutive outpatients undergoing colonoscopy were studied. Patients with previous colonic resections were excluded. Procedures were commenced with antispasmodics only, and patient sedation was self-administered whenever significant discomfort was experienced, using a patient-controlled analgesia (PCA) syringe pump. All "demands" were correlated with the MEI record, which was subsequently analysed.
Evaluation of QT dispersion in β thalassaemia major patients
Authors: Zulal Ulger, Yesim Aydinok, Erturk Levent, Dolunay Gurses, A. Ruhi Ozyurek
Journal: American Journal of Hematology (2006)

Abstract Cardiac complications are considered to be the primary cause of death in patients with β thalassaemia major. QT dispersion is a marker variability of ventricular repolarization and is elevated in various high risk groups of patients. This study was carried out in patients with β thalassaemia major to evaluate QT dispersion and to investigate the relationship between QT dispersion and body iron load. Sixty‐two β thalassaemia major patients were enrolled into the study. The average serum ferritin levels and liver iron concentration was assessed. For each patient, QT–QTc intervals and QT–QTc dispersions were calculated and V1S and V5R were measured. All the subjects underwent two‐dimensional M mode echocardiogram and Doppler study. LVMI was found higher in thalassaemia major patients compared to control group. β thalassaemia major patients showed significantly higher mean QT, QTc, QTd, and QTcd values compared to the control group. The mean V5R and V1S amplitudes were also higher in β thalassaemia major patients. There was a positive correlation between LVMI and QTc, QTd and QTcd. However, there was no significant correlation between QT dispersion and serum ferritin and liver iron concentration. Prospective longitudinal studies are needed to assess the prognostic significance of these findings. Am. J. Hematol., 2006. © 2006 Wiley‐Liss, Inc.
G-CSF administration in acute myocardial infarction: what is the best timing? Reply
Authors: W. Shim, A. Mehta, C. Hee Lim, T. Chua, P. Wong
Journal: Cardiovascular Research (2011)

We welcome the interest of Maggiolini and colleagues in our recent article on granulocyte colony-simulating factor (G-CSF) in acute myocardial infarction (AMI),1 arguing for early (hours rather than days) G-CSF administration in relation to its observed beneficial effects in functional recovery post-AMI. Indeed, mixed outcomes from clinical trials point to several outstanding issues that await further investigation. Chief among them is a clinically practicable window of G-CSF administration for cytokine-mobilized stem cell therapy. We agree with the authors that meta-analysis has indicated a positive correlation between G-CSF timing and left ventricular ejection fraction (LVEF) outcome, though current available literature on this topic remains controversial and consensus has yet to emerge. The crux of the issue stems from the following issues: 

1.  The challenging task of comparing results from different patient cohorts of published …
Nanoparticulation of BCG-CWS for application to bladder cancer therapy
Authors: Takashi Nakamura, Masafumi Fukiage, Megumi Higuchi, Akihiro Nakaya, Ikuya Yano, Jun Miyazaki, Hiroyuki Nishiyama, Hideyuki Akaza, Toshihiro Ito, Hiroyuki Hosokawa, Toshinori Nakayama, Hideyoshi Harashima
Journal: Journal of Controlled Release (2014)
SI Units for Clinical Measurement
Authors: Ivan Damjanov
Journal: Annals of Internal Medicine (1998)

Medical Writings15 September 1998SI Units for Clinical MeasurementIvan Damjanov, MD, PhDIvan Damjanov, MD, PhDUniversity of Kansas School of Medicine, Kansas City, KansasSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-129-6-199809150-00030 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail SI Units for Clinical Measurement; Young DS, Huth EJ. 331 pages. Philadelphia: American Coll Physicians; 1998. $36.00. ISBN 0943126517. Order phone 800-523-1546, ext. 2600.Field of medicine: Laboratory medicine.Format: Softcover book.Audience: All physicians who report or interpret laboratory data.Purpose: To assist with conversion of the traditional laboratory units currently used in most U.S. hospitals and laboratories into international SI units (le Systeme International d'Unites), which are endorsed by the World Health Organization (WHO) and are used in most countries other than the United States.Content: Approximately 75% of the book consists of tables. The major table lists ... Author, Article, and Disclosure InformationAffiliations: University of Kansas School of Medicine, Kansas City, Kansas PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byEmotion regulation training in the treatment of obesity in young adolescents: protocol for a randomized controlled trial 15 September 1998Volume 129, Issue 6Page: 511-512KeywordsForecastingGlobal healthResearch laboratories ePublished: 15 August 2000 Issue Published: 15 September 1998 Copyright & PermissionsCopyright © 1998 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
National Case-Control Study of Kaposi's Sarcoma and Pneumocystis carinii Pneumonia in Homosexual Men: Part 2, Laboratory Results
Authors: MARTHA F. ROGERS
Journal: Annals of Internal Medicine (1983)

The Centers for Disease Control conducted a case-control study to investigate an outbreak of Kaposi's sarcoma and Pneumocystis carinii pneumonia in homosexual men. The occurrence of these diseases was found to be associated with certain aspects of lifestyle, including a greater number of male sex partners per year, exposure to feces during sex, history of syphilis and non-B hepatitis, treatment for enteric parasites, and use of various illicit substances. Laboratory studies reflected both this lifestyle and the probable underlying cause of the Kaposi's sarcoma and P. carinii pneumonia--cellular immune deficiency. Patients were found to have lymphopenia, specifically a deficiency of the T-helper subpopulation, resulting in a reversal of the T-helper to T-suppressor ratio. Levels of IgG and IgA were increased. When compared with controls, patients were also found to have significantly higher titers of antibody to Epstein-Barr virus and cytomegalovirus, a higher prevalence of antibody to hepatitis A virus and Treponema pallidum, a lower prevalence of antibody to varicella zoster virus, and a higher frequency of isolation of cytomegalovirus.
Diuretic agents: inciting factor in nonocclusive mesenteric infarction?
Authors: J. B. Sharefkin
Journal: JAMA (1974)

Mesenteric infarction in the absence of organic vascular occlusion represents the most common and lethal variety of intestinal ischemia. Hemorrhagic shock, decreases in splanchnic perfusion of cardiac origin, and digitalis glycosides have been implicated in the pathogenesis of this entity, but no single causative factor can be identified in a significant number of individuals. Three patients are described in whom massive extracellular volume deficits induced by diuretic therapy initiated the development of nonocclusive mesenteric ischemia. Drastic diuresis should be monitored meticulously in patients with cardiac disease, especially in those taking digitalis or its derivatives. (<i>JAMA</i>229:1451-1453, 1974)
Dr. Charles Henry Ray
Authors: Emmet F. Pearson
Journal: JAMA (1974)

... with all my infidelity to medicine as a science, I retain my faith in the specific curative virtues of that article (quinine)... that and sulphur are the only certain remedies in the whole pharmacopoeia.<sup>1</sup> SO WROTE Dr. Charles Henry Ray to his wife, Jane, when he prescribed for his daughter Minnie's fever on March 23, 1854, thus expressing his disenchantment with medical practice of the times. Soon thereafter, this Illinois doctor forsook medicine for politics and journalism. He became editor of the<i>Chicago Tribune</i>just in time to boost Abraham Lincoln in his emergence on the national political scene. Destiny appeared to have attracted many doctors of strong character to Springfield, Ill, during the time that Abraham Lincoln lived there, and several of them had profound influence on Lincoln's health, his philosophy of life, his marriage, his statesmanship, and his political career.<sup>2</sup>Few individuals had more significant influence
Comparative Evaluation of Immunochemical Fecal Occult Blood Tests for Colorectal Adenoma Detection
Authors: Sabrina Hundt, Ulrike Haug, Hermann Brenner
Journal: Annals of Internal Medicine (2009)

Background: Different immunochemical fecal occult blood tests (FOBTs) have been proposed for noninvasive colorectal cancer screening. Large-scale, colonoscopy-based screening studies that allow evaluation of these tests for the detection of precursor lesions are scarce. Objective: To determine and compare performance characteristics of 6 qualitative immunochemical FOBTs for identifying colorectal adenomas among adults who attended screening colonoscopy examinations. Design: Prospective screening study from January 2006 to December 2007. Setting: 20 gastroenterology practices in Germany that did screening colonoscopy. Patients: 1319 participants at average risk for colorectal neoplasia who were undergoing screening colonoscopy (mean age, 63 years; 50% men). Measurements: 6 different qualitative immunochemical FOBTs were done with stool samples collected before bowel preparation for colonoscopy. Performance characteristics (sensitivity, specificity, predictive values, and likelihood ratios) of tests were measured by comparing test results with findings on colonoscopy. Technicians who read the tests were blinded to colonoscopy results, and colonoscopists were blinded to FOBT results. Results: Overall, 405 participants (31%) had an adenoma and 130 participants (10%) had an advanced adenoma. Performance characteristics varied widely among tests. For the 2 best-performing tests (immoCARE-C [CAREdiagnostica, Voerde, Germany] and FOB advanced [ulti med, Ahrensburg, Germany]), the sensitivity for detection of advanced adenomas was 25% (95% CI, 18% to 34%) and 27% (CI, 20% to 35%), respectively; specificity was 97% (CI, 95% to 98%) and 93% (CI, 91% to 95%); and the positive likelihood ratio was 3.5 (CI, 2.2 to 5.4) and 2.5 (CI, 1.9 to 3.5). Limitation: The study differed from real-life conditions in that stool samples were not directly dissolved in a buffer-filled vial; instead, a small container was used and stool was frozen before testing. Conclusion: Qualitative immunochemical FOBTs could be an option for future colorectal cancer screening because they showed better performance characteristics for precursor lesions than guaiac-based FOBTs and are practical for mass screening. However, given the large differences in diagnostic performance among tests, careful evaluation of the different test variants is important. Funding: The German Research Foundation (Deutsche Forschungsgemeinschaft) within the framework of a PhD program (Graduiertenkolleg 793).
Depressive Symptoms and Glycemic Control in Adolescents With Type 1 Diabetes
Authors: Meghan E. McGrady, Lori Laffel, Dennis Drotar, David Repaske, Korey K. Hood
Journal: Diabetes Care (2009)

OBJECTIVE To determine whether the association between depressive symptoms and glycemic control is mediated by blood glucose monitoring (BGM). RESEARCH DESIGN AND METHODS A total of 276 adolescents with type 1 diabetes (mean age ± SD, 15.6 ± 1.4 years) completed a measure of depressive symptoms. Sociodemographic and family characteristics were obtained from caregivers. BGM frequency and glycemic control were obtained at a clinic visit. RESULTS Separate regression analyses revealed that depressive symptoms were associated with lower BGM frequency (B = −0.03; P = 0.04) and higher A1C (B = 0.03; P = 0.05) and that lower BGM frequency was associated with higher A1C (B = −0.39; P &amp;lt; 0.001). With depressive symptoms and BGM frequency included together, only BGM frequency was associated with A1C and depressive symptoms became nonsignificant (B = 0.02; P = 0.19). The Sobel test was significant (Z = 1.96; P &amp;lt; 0.05) and showed that 38% of the depression-A1C link can be explained by BGM. CONCLUSIONS BGM is a mediator between depressive symptoms and glycemic control in adolescents with type 1 diabetes.
Social Capital and Successful Aging: The Role of Senior Housing
Authors: Carolyn Cannuscio
Journal: Annals of Internal Medicine (2003)

Social capital is defined as the resources available to individuals and groups through social connections and social relations with others. Access to social capital enables older citizens to maintain productive, independent, and fulfilling lives. As the U.S. population ages, accompanied by a rise in the prevalence of seniors living alone, the availability of social capital within communities will become an important ingredient of successful aging. Recent evidence suggests that many traditional forms of social capital in communitiesas represented by civic engagement in local associations and by the extent of voluntarism and social trustare on the decline. If this observation in correct, there is no simple solution to rebuilding this lost social capital. Novel forms of senior housing, such as planned care developments and assisted-living facilities, may offer promising modes of delivery of social capital to the aging population. However, assisted living remains financially inaccessible for a large segment of the U.S. population, so investment in communities aging in place may be the key to delivering the health dividends of social capital.