FUNCTIONING MALIGNANT BRONCHIAL CARCINOID WITH CUSHING'S SYNDROME AND RECURRENT SINUS ARREST
Authors: W E ESCOVITZ, I M REINGOLD
Journal: Annals of Internal Medicine (1961)

Case Reports1 June 1961FUNCTIONING MALIGNANT BRONCHIAL CARCINOID WITH CUSHING'S SYNDROME AND RECURRENT SINUS ARRESTWILLIAM E. ESCOVITZ, M.D., IRVING M. REINGOLD, M.D.WILLIAM E. ESCOVITZ, M.D.Search for more papers by this author, IRVING M. REINGOLD, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-54-6-1248 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptFor many years bronchial carcinoid, a type of bronchial adenoma, was considered not to be potentially malignant. In 1937, however, Zamora and Schuster1 mentioned the first case of metastasis from a bronchial adenoma. A correlation between malignant carcinoid tumors of the small intestine and a bizarre syndrome, subsequently called "carcinoid syndrome," was emphasized by Thorson et al.2 in 1954.In 1956 MacDonald3reviewed 57 cases of carcinoid syndrome with the primary tumor in the gastrointestinal tract. In the same year, Mattingly4in a thorough review of the literature described the functioning carcinoid tumor. Through 1959 a total of at least...Bibliography1. ZamoraSchuster AMNH: Vascular adenoma of bronchus. J. Laryng. 52: 337-343, 1937. CrossrefGoogle Scholar2. ThorsonBiörckBjörkmanWaldenström AGGJ: Malignant carcinoid of the small intestine with metastases to the liver, valvular disease of the right side of the heart (pulmonary stenosis and tricuspid regurgitation without septal defects), peripheral vasomotor symptoms, broncho-constriction, and an unusual type of cyanosis. Amer. Heart J. 47: 795-817, 1954. CrossrefMedlineGoogle Scholar3. 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DockertyMcGoonFontanaScudamore MBDCRSHH: Metastasizing bronchial carcinoid with hyperserotonemia and the carcinoid syndrome. Med. Clin. N. Amer. 42: 975-979, July 1958. CrossrefMedlineGoogle Scholar9. SchnecklothMcIsaacPage REWMIH: Serotonin metabolism in carcinoid syndrome with metastatic bronchial adenoma. J. A. M. A. 170: 1143-1147, 1959. CrossrefMedlineGoogle Scholar10. Case Records of the Massachusetts General Hospital (Case 44491). New Engl. J. Med. 259: 1128-1134, 1958. CrossrefMedlineGoogle Scholar11. Southren AL: Functioning metastatic bronchial carcinoid with elevated levels of serum and cerebrospinal fluid, serotonin, and pituitary adenoma. J. Clin. Endocr. 20: 298-305, 1960. CrossrefGoogle Scholar12. KovachKyle RDLH: Cushing's syndrome and bronchogenic carcinoma. Amer. J. Med. 24: 981-988, 1958. CrossrefMedlineGoogle Scholar13. UdenfriendTitusWeissbach SEH: Identification of 5-hydroxy-3-indoleacetic acid in normal urine and method for its assay. J. Biol. 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SmithNylusDalglieshDuttonLennoxMacFarlane ANLMCERWBPS: Further observations on the endocrine aspects of argentaffinoma. Scott. Med. J. 2: 24-38, 1957. CrossrefMedlineGoogle Scholar21. DockertyScheifley MBCH: Metastasizing carcinoid—report of an unusual case with episodic cyanosis. Amer. J. Clin. Path. 25: 770, 1955. CrossrefMedlineGoogle Scholar22. ZarafonetisKalas CJJP: Serotonin degradation by ceruloplasmin and its inhibition by isoniazid and iproniazid. Amer. J. Med. Sci. 239: 203-206, 1960. CrossrefMedlineGoogle Scholar23. Davies P: Sinoauricular block associated with intrathoracic new growths. Brit. Heart J. 19: 431-434, 1957. CrossrefMedlineGoogle Scholar24. ReingoldEscovitz IWE: Metastatic cutaneous carcinoid. Arch. Derm. 82: 971-975, 1960. CrossrefMedlineGoogle Scholar25. FriedbergKahnScheuerBleiferDack CKMJSS: Adams-Stokes syndrome associated with chronic heart block; treatment with corticosteroids. J. A. M. A. 172: 1146-1152, 1960. CrossrefMedlineGoogle Scholar26. PlotzKnowltonRagan CMAIC: Natural history of Cushing's syndrome. Amer. J. Med. 13: 597-614, 1952. CrossrefMedlineGoogle Scholar27. Thorne MG: Cushing's syndrome associated with bronchial carcinoma; enquiry into relationship of this syndrome to neoplastic disease. Guy. Hosp. Rep. 101: 251-272, 1952. MedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Long Beach, California*Received for publication May 2, 1960.From the Pulmonary Service and Laboratory Service, Veterans Administration Hospital, Long Beach 4, Calif.Requests for reprints should be addressed to William E. Escovitz, M.D., Pulmonary Service, Veterans Administration Hospital, Long Beach 4, Calif. 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GORMAN HILLS, M.D., KENNETH A. WOEBER, M.B., Ch.B. 1 June 1961Volume 54, Issue 6Page: 1248-1259KeywordsAdenomasCarcinoid tumorElectrocardiographyGastrointestinal tractGratitudeHeartMalignant tumorsResearch laboratoriesSmall intestineTestes ePublished: 1 December 2008 Issue Published: 1 June 1961 PDF downloadLoading ...