tbuckley/cabot-search huggingface dataset:
Kindred Coexistence of Medullary Sponge Kidney and Medullary Cystic Disease
Authors: WILLIAM B. BENNETT
Journal: Annals of Internal Medicine (1976)

Comments1 December 1976Kindred Coexistence of Medullary Sponge Kidney and Medullary Cystic DiseaseWILLIAM B. BENNETT, M.D.WILLIAM B. BENNETT, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-85-6-829_1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: Kliger and Scheer (1) recently reported the occurrence of uremic medullary cystic disease in three female siblings, and radiographic abnormalities indistinguishable from medullary sponge kidney in seven of 12 children of these women. The kindred described below confirms this association but casts some doubt on the suggestion of Kliger and Scheer that the medullary radiographic signs are indicative of preclinical medullary cystic disease.The proband, a 20-year-old white man was admitted to the University of Oregon Hospital for evaluation of fatigue and weakness of 6 months' duration.At admission his blood pressure was 110/60 mm Hg, with...References1. KLIGER A and SCHEER R: Familial disease of the renal medulla. A study of progeny in a family with medullary cystic disease. Ann Intern Med 85:190-194, 1976 LinkGoogle Scholar2. COPPING G: Medullary sponge kidney: its occurrence in a father and daughter. Can Med Assoc J 96:608-611, 1967 MedlineGoogle Scholar3. KUIPER J: Medullary sponge kidney in three generations. NY State J Med 71:2665-2669, 1971 MedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: WILLIAM B. BENNETT, M.D.Affiliations: Division of Nephrology Department of Medicine University of Oregon Health Sciences Center Portland, OR 97201 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byEnfermedades renales quísticasPolycystic Disease of the Kidney Coexisting with Medullary Sponge Kidney 1 December 1976Volume 85, Issue 6Page: 829-829KeywordsBlood pressureChildrenFatigueRenal diseases ePublished: 1 December 2008 Issue Published: 1 December 1976 PDF downloadLoading ...
Pain in the brain
Authors: Amy Maxmen
Journal: The Journal of Experimental Medicine (2008)

![Graphic][1] 

Aquaporin-4 (red) and EAAT2 (green) colocalize in normal spine.  A severe and unusual disorder often confused with multiple sclerosis (MS) has now become a little less mysterious. On page 

[2473][2], Hinson and colleagues demonstrate how the disease's distinguishing
ras activation in human tumors and in animal model systems.
Authors: M Corominas, S R Sloan, J Leon, H Kamino, E W Newcomb, A Pellicer
Journal: Environmental Health Perspectives (1991)

Environmental agents such as radiation and chemicals are known to cause genetic damage. Alterations in a limited set of cellular genes called proto-oncogenes lead to unregulated proliferation and differentiation. We have studied the role of the ras gene family in carcinogenesis using two different animal models. In one case, thymic lymphomas were induced in mice by either gamma or neutron radiation, and in the other, keratoacanthomas were induced in rabbit skin with dimethylbezanthracene. Human keratoacanthomas similar to the ones induced in rabbits were also analyzed. We found that different types of radiation such as gamma rays and neutrons, induced different point mutations in ras genes. A novel K-ras mutation in codon 146 has been found in thymic lymphomas induced by neutrons. Keratoacanthomas induced in rabbit skin by dimethylbenzanthracene show a high frequency of H-ras-activated genes carrying a mutation in codon 61. The same is observed in human keratoacanthomas, although mutations are in both the 12th and the 61st codons of the H-ras gene. H-ras activation is less frequent in human squamous cell carcinomas than in keratoacanthomas, suggesting that ras genes could play a role in vivo in differentiation as well as in proliferation.
A Possible Reservoir Host of Trypanosoma rhodesiense
Authors: W. A. Lamborn, C. H. Howat
Journal: BMJ (1936)

scopical examination of the urine, and radiological exam- ination of the entire urinary tract, at least every three months. Summary1.The incidence of 19.1 per cent. of urinary tract com- plications is reported in a series of 162 children who were undergoing prolonged recumbent treatment.2. Attention is drawn to the latency or absence of symp- toms and signs in these cases.3. Factors conducive to calculous disease, or pyogenic infection, of the urinary tract in recumbent patients are considered.The most important factors appear to be defective renal drainage, due to rigidly enforced dorsal posturization, and chronic focal sepsis.4. Brief allusion is made to certain aspects of diagnosis and prognosis, and a plea is made for the early detection of urological abnormalities.My thanks are due to Dr. J. G. Johnstone, medical superintendent of Princess Mary's Hospital, for permission to carry out the investigations upon which this paper is based and for many helpful suggestions.
Neonatal vitamin A supplementation for prevention of mortality and morbidity in infancy: systematic review of randomised controlled trials
Authors: S. Gogia, H. S. Sachdev
Journal: BMJ (2009)

<b>Objective</b> To evaluate the effect of neonatal vitamin A supplementation on infant mortality, morbidity and early adverse effects. <b>Design</b> Systematic review, meta-analysis, and meta-regression of randomised controlled trials. <b>Data sources</b> Electronic databases and hand search of reviews; abstracts and proceedings of conferences. <b>Review methods</b> Randomised or quasi-randomised or cluster randomised, placebo controlled trials evaluating the effect of prophylactic, neonatal (&lt;1 month) supplementation with synthetic vitamin A on mortality or morbidity within infancy (&lt;1 year), and early adverse effects (≤7 days). <b>Results</b> The six included trials were from developing countries. There was no convincing evidence of a reduced risk of mortality during infancy (relative risk 0.92, 95% confidence interval 0.75 to 1.12, P=0.393 random effect; I<sup>2</sup>=54.1%) or of an increase in early adverse effects including bulging fontanelle (1.16, 0.81 to 1.65, P=0.418; I<sup>2</sup>=65.3%). No variable emerged as a significant predictor of mortality, but data for important risk groups (high maternal night blindness prevalence and low birth weights) were restricted. Limited data (from one to four trials) did not indicate a reduced risk of mortality during the neonatal period (0.90, 0.75 to 1.08, P=0.270; I<sup>2</sup>=0%), cause specific mortality, common morbidities (diarrhoea and others), and admission to hospital. There was, however, evidence of an increased risk of acute respiratory infection and a reduced risk of clinic visits. <b>Conclusions</b> There is no convincing evidence of a reduced risk of mortality and possibly morbidity or of increased early adverse effects after neonatal supplementation with vitamin A. There is thus no justification for initiating such supplementation as a public health intervention in developing countries for reducing infant mortality and morbidity.
Principles of Geriatric Medicine
Authors: Frank L. Iber
Journal: JAMA (1985)

This new textbook is directed to the medical practitioner who cares for the elderly. It attempts to provide state-of-the-art discussions on knowledge of human aging, those changes of aging that are particularly pertinent to management, and, finally, aspects of management of specific problems. The authors provide brief and general reviews on the biology of human aging. A second section covers the epidemiology of aging, including thoughtful papers on the "Sex Differential in Aging," "Long Lived Populations," "Exercise and Aging," and "Preventive Health Services for the Elderly." There are four chapters on behavioral and social aspects of medicine followed by models of physicians' care of elderly patients. These four sections make up less than one fifth of the total pages. "Cardinal Manifestations of Aging and Disease of the Organ Systems" makes up the majority of the book and is patterned very similarly to many of the current textbooks of medicine. There
Do trypsin 2-alpha -1-antitrypsin complexes occur naturally in the circulation? Reply
Authors: A BORGSTROM, K OHLSSON, E KEMPPAINEN, J HEDSTROM, U-H STENMAN
Journal: Gut (1998)

Editor,—Some recent studies on the measurement of serum trypsin 2–α-1-antitrypsin complexes in the diagnosis of acute pancreatitis have piqued our interest,1 2 including that of Kemppainen et al ( Gut 1997; 41 :690–5). We published a couple of articles on trypsin 1–α-1-antitrypsin complexes in serum some years ago. Principally, we arrived at the same conclusion as the Finnish group—namely, that concentrations of these complexes in serum correlate with disease severity.3-5 

We had some problems with our assay in that we very often found low but measurable concentrations (5–25 μg/l) of trypsin 1–α-1-antitrypsin complexes in serum samples obtained from patients with no signs of acute pancreatitis. Our method was not sensitive enough to allow detailed characterisation of this low immunoreactivity and we were therefore not sure what it was comprised of. We did not publish these results as we found them hard to believe. If they were true it would mean that a substantial amount of trypsinogen was normally activated in and around the pancreas during the normal turnover of pancreatic enzymes (see later). Our hypothesis has always been that activation …
Pulmonary Edema — Hypoxia and Overperfusion
Authors: Norman C. Staub
Journal: New England Journal of Medicine (1980)

The report in this issue describing four subjects who had acute pulmonary edema after exertion at high altitude and who had congenital absence of the right pulmonary artery is intriguing, not just because it describes a medical curiosity but because of its wider implications.Approximately 5000 people have unilateral pneumonectomies annually in the United States, many for solitary lesions in otherwise normal lungs. Surely, one may expect that some of them travel to high altitude and that at least a few exercise there. Are they at high risk for acute pulmonary edema at high altitude? A study of this population . . .
High expression of activation-induced cytidine deaminase (AID) mRNA is associated with unmutated IGVH gene status and unfavourable cytogenetic aberrations in patients with chronic lymphocytic leukaemia
Authors: D Heintel, E Kroemer, D Kienle, I Schwarzinger, A Gleiß, J Schwarzmeier, R Marculescu, T Le, C Mannhalter, A Gaiger, S Stilgenbauer, H Döhner, C Fonatsch, U Jäger
Journal: Leukemia (2004)
The Healing Hand: Man and Wound in the Ancient World
Authors: E. DORINDA LOEFFEL
Journal: JAMA (1975)

Someday, medical practice circa 1975 will astound future generations by its naiveté, irrationality, and "cures that made matters worse," and 20th century thought will seem as obscure to our descendents as the practices of physicians in ancient Mesopotamia, Egypt, and Greece now seem to us. If we are lucky, Dr Guido Majno will be reincarnated every thousand years to resurrect our dusty medical archives and clarify our medical ideas. Undoubtedly, he would display the same energy, wit, and enthusiasm evident in the present book. However, instead of tackling mummies, bones, hieroglyphics, excavations, and artwork, he would have to scrutinize miles of microfilm and millions of tons of journals, deciphering longforgotten computer codes, laboratory results, and operative procedures. With enormous curiosity and indepth knowledge of pathology, Dr Majno has analyzed the development of wound care, surgery, and anatomical knowledge between 3000 BC and AD 200. The major civilizations included in his
The AGC kinase SGK1 regulates TH1 and TH2 differentiation downstream of the mTORC2 complex
Authors: Emily B Heikamp, Chirag H Patel, Sam Collins, Adam Waickman, Min-Hee Oh, Im-Hong Sun, Peter Illei, Archna Sharma, Aniko Naray-Fejes-Toth, Geza Fejes-Toth, Jyoti Misra-Sen, Maureen R Horton, Jonathan D Powell
Journal: Nature Immunology (2014)
Distinct Narcolepsy Syndromes in Orexin Receptor-2 and Orexin Null Mice
Authors: Jon T. Willie, Richard M. Chemelli, Christopher M. Sinton, Shigeru Tokita, S.Clay Williams, Yaz Y. Kisanuki, Jacob N. Marcus, Charlotte Lee, Joel K. Elmquist, Kristi A. Kohlmeier, Christopher S. Leonard, James A. Richardson, Robert E. Hammer, Masashi Yanagisawa
Journal: Neuron (2003)
Doxorubicin-induced inhibition of prolyl hydroxylation during collagen biosynthesis in human skin fibroblast cultures. Relevance to imparied wound healing.
Authors: T Sasaki, K C Holeyfield, J Uitto
Journal: Journal of Clinical Investigation (1987)

Previous clinical and experimental observations have indicated that wound healing is impaired as a result of treatment with doxorubicin, a chemotherapeutic agent. In this study, the effects of doxorubicin were examined in human skin fibroblast cultures with respect to collagen production and fibroblast proliferation. The results indicated that the synthesis of hydroxyproline as a marker of collagen production was markedly reduced, with an approximate concentration of inhibitor yielding 50% inhibition of 1 microM. This inhibition could be explained, in part, by generalized inhibition of total protein synthesis, but in addition, there was a significant inhibition of prolyl hydroxylation during collagen biosynthesis, as indicated by a reduction in the ratio of [3H]hydroxyproline/([3H]hydroxyproline + [3H]proline). The latter effect was shown to result from inhibition of prolyl hydroxylase by doxorubicin. As a consequence of reduced prolyl hydroxylation, the stability of newly synthesized procollagen triple helix was shown to be compromised. At the same time, doxorubicin significantly reduced fibroblast proliferation in vitro, as determined by [3H]thymidine incorporation. Thus, reduced collagen production and inhibition of fibroblast proliferation may explain the reduced wound healing in patients undergoing treatment with doxorubicin.
IMPACT OF HYPERCHOLESTEROLEMIA ON ATHEROSCLEROTIC PLAQUE COMPOSITION: A VIRTUAL HISTOLOGY INTRAVASCULAR ULTRASOUND ANALYSIS FROM PROSPECT
Authors: Adriano M. Caixeta, Giora Weisz, Akiko Maehara, Gary S. Mintz, Ecaterina Cristea, Roxana Mehran, Martin Fahy, Ke Xu, Alexandra J. Lansky, John McPherson, Bernard De Bruyne, Patrick W. Serruys, Gregg W. Stone
Journal: Journal of the American College of Cardiology (2011)
Cardiac Allograft Vasculopathy
Authors: Jeffrey D. Hosenpud, John P. Everett, Tony E. Morris, Kimberly A. Mauck, Gary D. Shipley, Cynthia R. Wagner
Journal: Circulation (1995)

Background Cardiac allograft vasculopathy (CAV) is an accelerated form of coronary artery disease responsible for the majority of late deaths after cardiac transplantation. Although most consider this complication a manifestation of chronic allograft rejection, it has not been established whether this disease is a consequence of humoral or cell-mediated alloreactivity. Methods and Results Human aortic endothelial cells (HAECs) were isolated from donor aortas obtained at the time of organ acquisition for 52 cardiac allograft recipients. Serum and peripheral blood mononuclear cells were obtained from these 52 allograft recipients at several time points during the first year after transplantation. Lymphocyte proliferation (LP) in response to donor-specific HAECs and alloantibody binding to interferon-γ–treated donor-specific HAECs were performed and correlated with clinical parameters, including HLA matching, acute cellular rejection, and coronary artery disease on surveillance angiography. Ten of the 52 patients studied had angiographic or autopsy evidence of coronary artery disease in the first posttransplantation year (CAV+ group). The CAV+ group had higher LP responses to their donor HAECs at 1 week, 3 months, and 6 months after transplantation compared with the CAV− group (1 week: 1439±222 versus 824±141 counts per minute [cpm], P =.026; 3 months: 1282±388 versus 884±94 cpm, P =.07; 6 months: 2504±635 versus 1540±209 cpm, P =.036; CAV+ versus CAV−, respectively). Only 8 of the 52 patients had donor-specific alloantibodies, and there was no relation between antibody presence and CAV. Other clinical parameters that correlated with CAV included the level of HLA-DR mismatch and the presence of late acute rejection. Conclusions CAV is associated with donor-specific cell-mediated alloreactivity to vascular endothelium. Humoral immunity does not appear to have a major role in this disease.
Systems Analysis of BCL2 Protein Family Interactions Establishes a Model to Predict Responses to Chemotherapy
Authors: Andreas U. Lindner, Caoimhín G. Concannon, Gerhardt J. Boukes, Mary D. Cannon, Fabien Llambi, Deborah Ryan, Karen Boland, Joan Kehoe, Deborah A. McNamara, Frank Murray, Elaine W. Kay, Suzanne Hector, Douglas R. Green, Heinrich J. Huber, Jochen H.M. Prehn
Journal: Cancer Research (2013)

Abstract Apoptotic desensitization is a hallmark of cancer cells, but present knowledge of molecular systems controlling apoptosis has yet to provide significant prognostic insights. Here, we report findings from a systems study of the intrinsic pathway of apoptosis by BCL2 family proteins and clinical translation of its findings into a model with applications in colorectal cancer (CRC). By determining absolute protein quantifications in CRC cells and patient tumor samples, we found that BAK and BAX were expressed more highly than their antiapoptotic inhibitors. This counterintuitive finding suggested that sole inhibition of effector BAX and BAK could not be sufficient for systems stability in nonstressed cells. Assuming a model of direct effector activation by BH3-only proteins, we calculated that the amount of stress-induced BH3-only proteins required to activate mitochondrial apoptosis could predict individual death responses of CRC cells to 5-fluorouracil/oxaliplatin. Applying this model predictor to protein profiles in tumor and matched normal tissue samples from 26 patients with CRCs, we found that differences in protein quantities were sufficient to model the increased tumor sensitivity to chemotherapy compared with normal tissue. In addition, these differences were sufficient to differentiate clinical responders from nonresponders with high confidence. Applications of our model, termed DR_MOMP, were used to assess the impact of apoptosis-sensitizing dugs in lowering the necessary dose of state-of-the-art chemotherapy in individual patients. Together, our findings offer a ready clinical tool with the potential to tailor chemotherapy to individual patients. Cancer Res; 73(2); 519–28. ©2012 AACR.
A Clinical Study of 1,000 Consecutive Cases of Mitral Stenosis Two to Nine Years after Mitral Valvuloplasty
Authors: LAURENCE B. ELLIS, DWIGHT E. HARKEN, HARRISON BLACK
Journal: Circulation (1959)

A study is presented of 1,000 cases of predominant mitral stenosis operated by valvuloplasty between 1949 and 1956. It is shown that the survival of these patients is better than would have been expected under medical management. Sixty-nine per cent of the survivors of the operation in groups II and III improved, and 55 per cent in group IV. Factors influencing the late results are discussed. After substantial improvement lasting a year or more, 228 of this series deteriorated; the factors affecting this deterioration are discussed, of which mitral insufficiency, an inadequate valvuloplasty, and recurrent rheumatic fever are the most striking.
Fourth International Congress on Peer Review in Biomedical Publication: Call for Research
Authors: Drummond Rennie
Journal: JAMA (1999)

We have now held four peer review congresses at four year intervals, and their success is shown by the stimulus they have given to an evolving science—investigation of the process whereby scientific work is selected and published.1–4 Since the announcement of the first peer review congress in 1986, the numbers of abstracts submitted to successive congresses have increased from 50 to 110, 160, and 180, respectively. We have noted similar increases in the number of Medline citations on peer review, which since 2000 have averaged 170-200 per year.5

We now …
Reviews and Notes: Diseases of the Breast
Authors: Cornelia Baines
Journal: Annals of Internal Medicine (1996)

Literature of Medicine15 November 1996Reviews and Notes: Diseases of the BreastCornelia Baines, MDCornelia Baines, MDUniversity of Toronto, Toronto, Ontario M5S 1A8, Canada.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-125-10-199611150-00025 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail JR Harris, ME Lippman, M Morrow, S Hellman; eds. 1047 pages. Philadelphia: Lippincott-Raven; 1996. $165.00. ISBN 0-397-51470-0. Order phone 800-777-2295.This appears to be a successor to the 1987 text titled Breast Diseases; Harris and Hellman have served as editors for both books. In addition to having an inverted title and two additional editors, the new text differs from the old with chapters on biochemistry, molecular epidemiology, oncogenes and suppressor genes, immunology and immunotherapy, molecular pathology, cytokinetics, screening, new imaging techniques, and new therapies. A quick look at texts on the breast available in a university library showed that the ... Author, Article, and Disclosure InformationAffiliations: University of Toronto, Toronto, Ontario M5S 1A8, Canada. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 15 November 1996Volume 125, Issue 10Page: 862KeywordsBreast cancerImmunologyLibrariesMammographyMolecular biologyMolecular epidemiologyMolecular pathologyOncogenesRadiologistsSleep ePublished: 15 August 2000 Issue Published: 15 November 1996 Copyright & PermissionsCopyright © 1996 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Clinical trials update from the Heart Failure Society of America Meeting 2009: FAST, IMPROVE‐HF, COACH galectin‐3 substudy, HF‐ACTION nuclear substudy, DAD‐HF, and MARVEL‐1
Authors: Mitja Lainscak, Alison P. Coletta, Nasser Sherwi, John G.F. Cleland
Journal: European Journal of Heart Failure (2009)
Age as a Risk Factor for Inadequate Treatment
Authors: M. Eshleman, J. O'Shea, E. Cyran, J. L. Smith, A. Y. C. Chang, K. J. Pandya
Journal: JAMA (1988)

<h3>To the Editor.</h3> —We agree with the comments in the recent editorial<sup>1</sup>in the July 24/31 issue of<i>JAMA</i>. This editorial prompted us to review our experience at St Mary's Hospital, a 300-bed community hospital and a major teaching affiliate of the University of Rochester (NY) School of Medicine. <h3>Study.</h3> —We reviewed the charts of all patients seen by the oncology service who were aged 75 years or older at the time of the first oncology consultation and who were seen after September 1983, the date when the Community Clinical Oncology Program sponsored by the National Cancer Institute began. A total of 125 patients were found, 85 of whom had one of four solid tumors (lung, breast, colon/rectum, and prostate). Complete information was found on 81 of the 85 charts and this was used as our database. Our results are summarized in the Table. We defined the "Treated" group