tbuckley/cabot-search huggingface dataset:
Australian radiologists face prosecution for fraud
Authors: Christopher Zinn
Journal: BMJ (2000)

A quarter of Australia's 1100 radiologists could face prosecution after a report found that they used their insider knowledge of certain upcoming Budget changes to make huge financial gains. The largest medical fraud investigation for 25 years showed that radiologists bought scanners with the secret knowledge that they would be able to claim large rebates on all scans done on Medicare patients after May 1998.

The specialists have been accused of forging dates on contracts for magnetic resonance imaging machines to qualify for the lucrative rebates, because the rebates were only payable on scans done on machines bought before the May, 1998, budget. Others scrambled to buy machines before that date, as soon as they learnt of …
Abstract 13187: Abnormalities in Cardiac Strain are Found in Young Adults with Type 2 Diabetes Mellitus
Authors: Nicolas L Madsen, Philip R Khoury, Zhiqian Gao, Stephanie N Stewart, Lauren Longshore, Amy Shah, Lawrence M Dolan, Thomas R Kimball, Elaine M Urbina
Journal: Circulation (2014)

Introduction: Diabetic cardiomyopathy in adults begins with diastolic dysfunction progressing to systolic dysfunction and heart failure. Tissue Doppler imaging to measure strain and strain rate may demonstrate abnormalities earlier in the process than traditional echo. We hypothesized that abnormal strain can be found in young adults with Type II Diabetes Mellitus (T2DM). Methods: Comprehensive echocardiography and speckle-tracking imaging was measured in 338 subjects (22.2 + 3.7 years, 38% male, 63% African American) stratified into lean (L=112), obese (O=121) and T2DM (T=105) groups. Anthropometrics, BP, HR, fasting lipids, glucose and CRP were collected. Echocardiograms were performed on a GE Vivid 7 machine and read with EchoPAC®software for global longitudinal (4-chamber) strain (GS) and strain rate in systole (GSRs), early diastole (GSRe) and active diastolic phase (GSRa). ANOVA was performed to compare differences among groups for CV risk factors and strain measures and ANCOVA to determine if prese...
Abstract 15011: Genetic Variants in ABCG5/G8 Are Associated With Primary Hypercholesterolemia
Authors: Itziar Lamiquiz-Moneo, Ana M Bea, Rocío Mateo-Gallego, Ana Cenarro, Lucia Baila-Rueda, Fernando Civeira, Isabel De Castro-Orós
Journal: Circulation (2014)

Introduction: A large proportion of subjects with primary hypercholesterolemia do not have a causative mutation in LDLR, APOB, or PCSK9. GWAs have identified ABCG5 and ABCG8 associated with LDL cholesterol (LDLc) levels. ABCG5/G8 encode for transporters that play an important role in decreasing sterols intestinal absorption and promoting its biliary excretion. The downexpression in ABCG5/G8 produce an increase of cholesterol into the VLDL and LDL leading to hypercholesterolemia.

Hypothesis: ABCG5/G8 genetic variants are associated with primary hypercholesterolemia.

Methods: We have sequenced ABCG5 and ABCG8 promoters, coding regions, and intron-exon boundaries in 191unrelated subjects with LDLc >95th percentile, triglycerides <200 mg/dl and body mass index (BMI) <27.5 kg/m2 and no mutation in PCSK9, LDLR and APOB. Bioinformatical analysis were carried out with MutationTaster, PolyPhen-2 and SIFT and statistical analysis were performed using SPSS software v.20.

Results: We have identified 21 and 25 previously identified variants in ABCG5 and ABCG8 respectively. In addition, we have found a new ABCG5 variant p.(Asn285Ser). By comparing the allelic frequencies of those variants with the reported by 1000 Genomes Project we have found differences with statistical significance in 10 and 7 SNPs in ABCG5 and ABCG8 respectively. Three of these changes have been predicted as damaging or disease causing by Bioinformatical analysis: p.Arg50Cys, p.Asn440Lys and p.Val151Val. Multivariate lineal regression using LDLc as dependent variable has shown that c.502-273A>G in ABCG5, BMI and c.*380T>G in ABCG5 explain independently of age and gender the 13,1% of the LDLc variability (p=0.002).

Conclusions: Common and rare genetic variants in ABCG5/G8 are associated with primary hypercholesterolemia. Common ABCG5 variants explain a substantial proportion of LDLc in primary hypercholesterolemia, suggesting a polygenic background in some cases with this phenotype.

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Progression From Paroxysmal to Persistent Atrial Fibrillation
Authors: Cees B. de Vos, Ron Pisters, Robby Nieuwlaat, Martin H. Prins, Robert G. Tieleman, Robert-Jan S. Coelen, Antonius C. van den Heijkant, Maurits A. Allessie, Harry J.G.M. Crijns
Journal: Journal of the American College of Cardiology (2010)
Abstract P190: Validity and Reproducibility of a Food Frequency Questionnaire to Assess Compliance to a Cardioprotective Mediterranean Diet
Authors: Jennifer Cantin, Sébastien Lacroix, Élise Latour, Jean Lambert, Julie Lalongé, May Faraj, Anil Nigam
Journal: Circulation (2014)

Background: The cardioprotective effects of the Mediterranean diet have been well established in epidemiological studies. More recently, it has been shown to improve the cardiometabolic risk profile and endothelial function, as well as reduce markers of vascular inflammation, independent of weight loss. Since cardiovascular disease is the second cause of death in the Canadian and North American populations, randomized clinical trials evaluating the efficacy of the Mediterranean diet in high-risk primary and secondary prevention are warranted. In order to conduct such studies, validated dietary assessment methods specific to population and food habits are needed. Therefore, the aim of our study was to assess the reproducibility and the relative validity of a quantitative food frequency questionnaire (FFQ) to be used in clinical trials at the Montreal Heart Institute’s Prevention Center. Methods: Fifty (50) participants (54% (27 of 50) women) aged 19 to 86 years with and without coronary disease were recruited, and randomized in 3 groups in a crossover design where the sequence of administration of questionnaires differed in each group. The FFQ includes 157 food items and was designed to measure food intake over one month. It was administered twice 3 to 5 weeks apart to assess reproducibility and was compared to a 12-day dietary record carried out over a 1-month period to assess validity. Participants were asked not to modify their diet for the duration of the study. FFQs were self-administered and reviewed by a registered dietician. All questionnaires were analyzed using The Food Processor software. Results: Reproducibility (n = 49) assessed by the intraclass correlation coefficient (ICC) revealed good (ICC &gt; 0.5) to very good (ICC &gt; 0.7) correlations for energy and all nutrients (except vitamin A) with ICCs ranging from 0.48 (95% confidence interval (CI), 0.23 to 0.67) for vitamin A to 0.91 (95% CI, 0.85 to 0.95) for alcohol (mean 0.68). Preliminary results for validity (n = 15) revealed very good significant correlations for EPA, DHA, selenium and alcohol and good significant correlation for energy, total fat, saturated fatty acids, monounsaturated fatty acids, oleic acid, linolenic acid, trans fat, vitamin B3, vitamin D, iron and magnesium. Conclusions: Our FFQ demonstrates good to very good reproducibility. Furthermore, the FFQ appears valid for evaluating adherence to a Mediterranean diet, notably because it provides very good estimates of marine omega-3 fatty acid (EPA, DHA) intake. These results support the eventual use of our FFQ in clinical trials on the Mediterranean diet. Complete sample analysis will be available in March 2014.
CDC: Autism Spectrum Disorders Common
Authors: Bridget M Kuehn
Journal: JAMA (2007)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Lesson of the week: Spontaneous rupture of Achilles tendon: missed presentation of Cushing's syndrome
Authors: A. Mousa, S. Jones, A. Toft, P. Perros
Journal: BMJ (1999)

Non-iatrogenic Cushing's syndrome is an uncommon endocrine disease with an estimated annual incidence of 0.7-2.4 cases per million.1 If untreated, Cushing's syndrome is associated with appreciable morbidity and premature death.2 3 The presenting clinical features may be non-specific, and the disease often remains undiagnosed for a considerable time. Spontaneous rupture of the Achilles tendon is unusual, but is well described in patients receiving long term steroid treatment.4–7 The incidence of spontaneous rupture of tendons in non-iatrogenic Cushing's syndrome is unknown. We report two patients with non-iatrogenic Cushing's syndrome who presented with spontaneous rupture of the Achilles tendon, one to an outpatient orthopaedic clinic and the other to an accident and emergency department. The diagnosis of Cushing's syndrome was made one month later in the first …
Malignant skin tumours in patients with inherited ichthyosis
Authors: K. Natsuga, M. Akiyama, H. Shimizu
Journal: British Journal of Dermatology (2011)

Inherited ichthyoses are rare genodermatoses caused by mutations in the genes involved in epidermal development. Although there have been case reports on patients with ichthyosis who developed skin malignancies, it is still unknown whether or not patients with ichthyosis have an increased risk of skin malignancies. Here, we review case series of skin malignancies in patients with ichthyosis and show biological findings which might lead to cancer susceptibility. A survey of the literature revealed 28 cases of inherited ichthyoses with skin malignancy, including 12 cases of keratitis-ichthyosis-deafness (KID) syndrome, seven of autosomal recessive congenital ichthyosis, three of Netherton syndrome and six of miscellaneous ichthyosis. Twenty-four of the 28 cases developed single or multiple squamous cell carcinomas (SCCs). The age at diagnosis of the first skin malignancy ranged from 15 to 54 years. As patients with these particular subtypes of ichthyosis seem to be prone to skin malignancies, including SCC, at an unusually young age, routine cancer surveillance of these patients is strongly recommended.
Abstract 13428: Cell Depletion Studies Identify CD8+ T cells as Mediators of Beneficial Effects of p210 Vaccination in Angiotensin-II Induced Aortic Aneurysm Formation and Rupture
Authors: Tomoyuki Honjo, Paul C Dimayuga, Kuang Yuh Chyu, Juliana Yano, Wai Man Lio, Xiaoning Zhao, Jianchang Zhou, Bojan Cercek, Prediman K Shah
Journal: Circulation (2014)

Background: We previously reported that vaccination with an apoB-100 peptide called p210 markedly reduced angiotensin-II (AngII) induced aortic aneurysm (AA) formation and mortality from AA rupture in apoE-/- mice. The cellular mediators involved have, however, not been clearly defined. We have also shown that the athero-protective effects of p210 immunization are mediated by modulation of CD8+ T cells. To determine the mechanistic role of CD8+ T cells in the protective effect of p210 immunization in AngII induced AA, we performed experiments depleting CD8+ T cells in p210 immunized mice. Methods and Results: ApoE-/- mice were immunized with the p210 vaccine at 7, 10, and 12 weeks of age. At 10 weeks of age, AngII was infused using an osmotic pump at a dose of 1000ng/kg/min for 4 weeks. Mice were injected with either a CD8 depleting antibody (CD8 Ab) or control IgG (Isotype) at a dose of 150μg 3 days before the first immunization and then twice a week thereafter. Splenocytes collected at euthanasia confir...
Clinical relevance of intracellular vascular endothelial growth factor levels in B-cell chronic lymphocytic leukemia
Authors: Alvaro Aguayo, Susan O'Brien, Michael Keating, Taghi Manshouri, Cristi Gidel, Bart Barlogie, Miloslav Beran, Charles Koller, Hagop Kantarjian, Maher Albitar
Journal: Blood (2000)
Simplified Infant Feeding: With Eighty Illustrative Cases.
Authors: Roger H. Dennett
Journal: JAMA (1926)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
49. AAV Vector-Mediated Gene Delivery of Aromatic L-Amino Acid Decarboxylase Restored L-DOPA Efficacy in a Primate Bilateral Model of Parkinson's Disease
Authors: Sophia Papadeas, George R. Breese, Thomas J. McCown
Journal: Molecular Therapy (2004)

Activity dependent neurotropic factor (ADNF) occurs endogenously in astrocytes, and both ADNF and the fragment, ADNF-9, exert potent neuroprotective properties (Brenneman et al., JPET:285,619,1998). Recently, Haberman et al. (Nat. Med.9:1076,2003) showed that the fibronectin secretory signal sequence (FIB) could be used to constitutively secrete an active gene product from neurons transduced by adeno-associated virus vectors(AAV) in vivo. Given the extraordinary potency of ADNF (femtomolar range), we conducted a study to determine if linking the FIB to the ADNF-9 coding sequence would prove sufficient to protect substantia nigra neurons from striatal infusions of the neurotoxin, 6-OHDA. Rats first received a 2 microliter unilateral striatal infusion of AAV-FIB-ADNF and one week later, received two unilateral striatal infusions of 6-OHDA (3.5 micrograms/ 1 microliter per infusion). Two weeks later, the rats were perfused, and the presence of tyrosine hydroxylase (TH) was determined immunohistochemically. In the striatum 6-OHDA treatment caused a significant loss of TH containing terminals both in the control and AAV-FIB-ADNF treated rats. In the substantia nigra, the control 6-OHDA rats exhibited a 47±5% decrease in TH positive cells compared to the untreated side. However, no decrease in TH containing cells was observed in the AAV-FIB-ADNF treated group. Thus, striatal infusion of AAV-FIB-ADNF protected substantia nigra TH containing neurons from 6-OHDA-induced cell death, a finding likely attributible to retrograde transport of the AAV-FIB-ADNF from the striatum to the substantia nigra. These findings illustrate the utility of AAV mediated expression and secretion of neuroprotective gene products in vivo.
Tropical high-altitude plant form and function Tropical alpine environments: Plant form and function edited by P. W. Rundel, A.P. Smith and F C. Meinzer Cambridge University Press, 1994. £65.00/$100.00 hbk (xiv + 376 pages) ISBN 0 521 42089 X
Authors: A Cleef
Journal: Trends in Ecology & Evolution (1995)
Erratum: Tumor suppressor BRCA1 epigenetically controls oncogenic microRNA-155
Authors: Suhwan Chang, Rui-Hong Wang, Keiko Akagi, Kyung-Ae Kim, Betty K Martin, Luca Cavallone, Diana C Haines, Mark Basik, Phuong Mai, Elizabeth Poggi, Claudine Isaacs, Lai M Looi, Kein S Mun, Mark H Greene, Stephen W Byers, Soo H Teo, Chu-Xia Deng, Shyam K Sharan
Journal: Nature Medicine (2011)
Pathology of Skeletal Muscle.
Authors: Stirling Carpenter, George Karpati
Journal: Annals of Internal Medicine (1985)

PART I: STRUCTURES AND REACTIONS 1. Introduction to Muscle Pathology 2. Methods of Tissue Removal and Preparation 3. General Aspects of Skeletal Muscle Biology 4. Major Pathological Reactions and Their Consequences for Skeletal Muscle Cells 5. Normal Organelles and Other Constituents of Skeletal Muscle Cells 6. Abnormal Organellar Structures in Skeletal Muscle Cells 7. Cells and Structures other than Skeletal Muscle Cells PART II: DISEASES OF SKELETAL MUSCLE 8. Genetic Diseases of Muscle 9. Sporadic Diseases of Skeletal 10. Denervation
Treating temporarily incompetent patients
Authors: R. Francis
Journal: BMJ (1995)

Competence cannot be determined by reasonableness of patient's decision

EDITOR,--Part of the recent discussion of the two case histories concerning the treatment of temporarily incompetent patients must be questioned.1 As Petra Wilson suggests, the mental competence required by law for valid consent to or refusal of medical treatment is not clearly defined, but the judge in the case cited analysed the abilities required, which were to comprehend and retain information about treatment, to believe such information, and to weigh the information …
Both sides now: a leap from academics to solo practice
Authors: Rebekah Wang-Cheng
Journal: BMJ (2003)

From BMJ USA 2003;April:208 

Posted on the outside of my office door were two of my favorite quotes: George Bernard Shaw's “I want to be thoroughly used up when I die. Life is no brief shining candle to me, but a brightly lit torch that I want to burn as brightly as possible before handing it on to the next generation,” and “Education is not the filling of a pail but the lighting of a fire” by William Butler Yeats. Teaching students and residents was indeed the “fire in my belly,” my calling and passion for 19 years, after I stumbled into an academic career straight out of residency.

Although numerous teaching awards had validated my career path, the best rewards were from the learners who often presented to my open door to ask advice about residency choices, balancing family life, personal dilemmas, or patient problems. That “aha moment” during rounds when the junior student made the connection between theory and clinical application got me up in the morning.

So how is …
Education of patients with sleep apnea syndrome: Feasibility of a phone coaching procedure
Authors: Alain Didier, Ludivine Leseux, Kamila Sedkaoui, Sandrine Pontier, Laurence Adrover, Jean Louis Fraysse
Journal: European Respiratory Journal (2011)

Introduction:  The most commonly used treatment for sleep apnea syndrome (SAS) is the application of constant airway pressure (CPAP) during sleep. However compliance with this treatment is frequently below 70%.   Methods:  The main aim of this study was to evaluate the feasibility of an educational intervention (EI) by phone calls in SAS patients (n=66) treated with CPAP by a home care provider (SADIR). The educational intervention consisted on 5-sessions (day 3, 10, 30, 60 and 90) of telephone-based counseling intervention by a competent staff. Secondary objectives were to compare using a case-control design CPAP compliance of SAS patients (n=133) with or without EI.   Results:  98% of patients accepted the intervention. Fifty seven patients (86%) received the full intervention program, and forty four patients (66%) strictly respected the protocol pre-defined timing. A higher adherence to CPAP at 6 months was observed in the EI group (94% versus 81%) compared to patient without EI (P   Conclusion:  An educational intervention dispensed by phone is applicable and would have an impact on CPAP compliance. Its efficacy on long term compliance has to be confirmed in a larger group using a randomized procedure.
Still Life With Monkey, Fruits, and Flowers
Authors: M. Therese Southgate
Journal: JAMA (1999)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal