CHRONIC HEMOLYTIC ANEMIA WITH PAROXYSMAL NOCTURNAL HEMOGLOBINURIA
Authors: Robert C. Manchester
Journal: Annals of Internal Medicine (1945)

Article1 December 1945CHRONIC HEMOLYTIC ANEMIA WITH PAROXYSMAL NOCTURNAL HEMOGLOBINURIAROBERT C. MANCHESTERROBERT C. MANCHESTERAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-23-6-935 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptINTRODUCTIONTwo cases of chronic hemolytic anemia with paroxysmal nocturnal hemoglobinuria, recently observed in this hospital, are reported in this paper and some of the clinical features are discussed. The concurrent malaria in case 2 precipitated severe hemolytic crises with hemoglobinuria erroneously diagnosed blackwater fever. This feature makes such cases of particular interest to civilian physicians as well as to medical officers of the armed forces, because of the prevalence of malaria among troops now engaged in Pacific warfare.CLINICAL DESCRIPTIONForty-eight cases have been reported1since the clinical entity was first described by Marchiafava and Nazarii in 1911. Contrary...Bibliography1. PIERCEALDRICH PPCA: Chronic hemolytic anemia with paroxysmal nocturnal hemoglobinuria (Marchiafava-Micheli syndrome). Report of case with marked thrombocytopenia in five year old child, Jr. Pediat., 1943, xxii, 30-42. CrossrefGoogle Scholar2. WINTROBE MW: Clinical hematology, 1942, Lea and Febiger, Philadelphia. CrossrefGoogle Scholar3. WITTS LJ: Paroxysmal hemoglobinurias, Lancet, 1936, ii, 115-120. CrossrefGoogle Scholar4. HAM TH: Studies on red blood cells. Chronic hemolytic anemia with paroxysmal nocturnal hemoglobinuria. Investigation of mechanism of hemolysis with observations on five cases, Arch. Int. Med., 1939, lxiv, 1271-1305. HAM, G. C., and HORAK, H. M.: Chronic hemolytic anemia with paroxysmal nocturnal hemoglobinuria. Report of case with only occasional hemoglobinuria and with complete autopsy, Arch. Int. Med., 1941, lxvii, 735-745. HAM, T. H., and DINGLE, J. H.: Studies on destruction of red blood cells. Chronic hemolytic anemia with paroxysmal nocturnal hemoglobinuria. Certain immunological aspects of the hemolytic mechanism with special reference to serum complement, Jr. Clin. Invest., 1939, xviii, 657-672. CrossrefGoogle Scholar5. HAMBERGERBERNSTEIN LPA: Chronic hemolytic anemia with paroxysmal nocturnal hemoglobinuria, Am. Jr. Med. Sci., 1936, cxcii, 301-316. CrossrefGoogle Scholar6. SCOTTROBB-SMITHSCOWEN RBAHEF: Marchiafava-Micheli syndrome of nocturnal hemoglobinuria with hemolytic anemia, Quart. Jr. Med., 1938, vii, 95-114. Google Scholar7. ROSENTHAL F: Über eine neue Form von paroxysmaler Hamoglobinurie, Ztschr. f. klin. Med., 1932, cxix, 449-459. Google Scholar8. ALTSHULEGILLIGAN MDDR: Acute massive hemoglobinuria of obscure cause with jaundice and anemia; report of a case with clinical and hematologic studies and measurements of the blood pigment metabolism, Arch. Int. Med., 1941, lxviii, 957-978. CrossrefGoogle Scholar9. FAIRLEY NH: Methemalbumin in man (pseudo-methemoglobin), Proc. Roy. Soc. Med., 1939, xxxii, 1278-1280. CrossrefGoogle Scholar10. FAIRLEY NH: Fate of extracorpuscular circulating hemoglobin, Brit. Med. Jr., 1940, 213-217. CrossrefMedlineGoogle Scholar11. GILLIGANALTSHULEKATERSKY DRMDEM: Studies of hemoglobinemia and hemoglobinuria produced in man by intravenous injection of hemoglobin solutions, Jr. Clin. Invest., 1941, xx, 177-187. CrossrefGoogle Scholar12. YUILE CL: Hemoglobinuria, Physiol. Rev., 1942, xxii, 19-31. CrossrefGoogle Scholar13. LICHTYHAVILLWHIPPLE JAWHGH: Renal thresholds for hemoglobin in dogs. Depression of threshold due to frequent hemoglobin injections and recovery during rest periods, Jr. Exper. Med., 1932, lv, 603-615. CrossrefGoogle Scholar14. NEWMANWHIPPLE WVGH: Renal thresholds for hemoglobin in dogs. Hemoglobin injections and conservation of pigment by kidney, liver and spleen. Influence of diet and bleeding, Jr. Exper. Med., 1932, lv, 637-652. CrossrefGoogle Scholar15. BOGNIARDWHIPPLE RPGH: Iron content of blood free tissues and viscera. Variations due to diet anemia and hemoglobin concentrations, Jr. Exper. Med., 1932, lv, 653-665. CrossrefGoogle Scholar16. HADEN RL: Hemolytic anemia, Jr. Lab. and Clin. Med., 1940, xxvi, 65-81. Google Scholar17. DACIEFIRTH JVD: Blood transfusions in nocturnal hemoglobinuria, Brit. Med. Jr., 1943, i, 627-628. Google Scholar18. ATKINSON FR: Lederer's anemia, Brit. Jr. Child. Dis., 1940, xxxvii, 35-44. Google Scholar19. DAMESHEKSCHWARTZ WSO: Acute hemolytic anemia (acquired hemolytic icterus, acute type), Med., 1940, xix, 231-327. CrossrefGoogle Scholar20. MASON VR: Acquired hemolytic anemia, Arch. Int. Med., 1943, lxii, 471-493. CrossrefGoogle Scholar21. FOYKONDI HA: Spleen puncture findings in blackwater fever, Trans. Roy. Soc. Trop. Med. and Hyg., 1938, xxxii, 347-354. CrossrefGoogle Scholar22. FAIRLEYMURGATROYD NHF: Recurrent blackwater fever induced by quinine, Trans. Roy. Soc. Trop. Med. and Hyg., 1940, xxxiv, 187-194. CrossrefGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: (MC) U.S.N.R. U. S. Naval Hospital Seattle, Washington*Received for publication February 7, 1945.This article has been released for publication by the Division of Publications of the Bureau of Medicine and Surgery of the United States Navy. The opinions and views set forth in this article are those of the writer and are not considered as reflecting the policies of the Navy Department. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byWashed and Volume-Reduced Blood ComponentsCutaneous necrosis during paroxysmal nocturnal haemoglobinuria: role of parvovirus B19?Washed and/or Volume-Reduced Blood ComponentsParoxysmal Nocturnal Hemoglobinuria as a Molecular DiseaseIron OverloadPlatelet hypersensitivity and intravascular coagulation in paroxysmal nocturnal hemoglobinuriaParoxysmal nocturnal haemoglobinuria with fatal puerperal stroke due to sagittal sinus thrombosisZur Therapie der paroxysmalen n�chtlichen H�moglobinurieA Splencctomized Case of Paroxysmal Nocturnal HemoglobinuriaChronic hemolytic anemia with paroxysmal nocturnal hemoglobinuria 1 December 1945Volume 23, Issue 6Page: 935-944KeywordsArmed forcesFeversHemoglobinHemolytic anemiaMalariaSurgery Issue Published: 1 December 1945 PDF downloadLoading ...