tbuckley/cabot-search huggingface dataset:
Abstract 6140: Value of Baseline Inferolateral Myocardial Contractile Function Assessed by Tissue Doppler Imaging to Predict Reduction of Functional Mitral Regurgitation with Low-Dose Dobutamine in Patients with Dilated Cardiomyopathy
Authors: Kazuhiro Tatsumi, Hiroya Kawai, Salem Omar, Yuko Fukuda, Mariko Okada, Kazuko Norisada, Maky Furuki, Tetsuari Onishi, Ken-ichi Hirata
Journal: Circulation (2008)

Dobutamine (DOB) has the ability to reduce functional mitral regurgitation (FMR) in dilated cardiomyopathy (DCM) and DOB stress echocardiography might be useful to make an optimal selection of surgical treatments such as isolated myocardial revascularization or in combination with valve repair. The purpose of this study was to investigate the relationship between baseline echocardiographic parameters including regional myocardial function and reduction of FMR with DOB. We studied 38 DCM patients with reduced left ventricular ejection fraction (LVEF) (33±11%) and FMR. Standard and tissue Doppler echocardiography were performed at rest and with low-dose DOB (10 μg/kg/min), and we obtained LV volume, LVEF, tenting area of mitral valve (enclosed between the annular plane and leaflets), mitral annular area (MAA), FMR fraction and, longitudinal peak systolic strain rate (Ssr; absolute value) in the 6 segments at mid-LV level using apical images. According to the reduction of FMR with DOB, patients were divided into a large reduction group (%FMR reduction ≥ 30%) and a small reduction group (&lt;30%), 17 and 21 patients, respectively. DOB increased LVEF and Ssr in all segments, and decreased LV volumes, tenting area, MAA, and FMR fraction (%FMR reduction = 28±19%) in all subjects. Regarding the baseline parameters, tenting area and FMR fraction in large reduction group were significantly smaller, and anterolateral Ssr and inferolateral Ssr in large reduction group were significantly larger than those in small reduction group. However, there was no difference in baseline LV volume, LVEF, MAA, nor Ssr in any other segments. In ROC curve analysis, the area under the curve for tenting area, FMR fraction, anterolateral Ssr, and inferolateral Ssr were 0.69, 0.70, 0.72, and 0.81, and baseline inferolateral Ssr &gt; 1.00/s was the best predictor of DOB-induced %FMR reduction ≥30% with a sensitivity of 88% and a specificity of 75%. Baseline inferolateral myocardial contractile function was associated with DOB-induced reduction of FMR, suggesting that assessment of inferolateral myocardial preserved function is important for an optimal selection of surgical treatment in patients with FMR.
THE LIFESPAN OF THE ERYTHROCYTES
Authors: Leopold Lichtwitz
Journal: Annals of Internal Medicine (1937)

Article1 May 1937THE LIFESPAN OF THE ERYTHROCYTESLEOPOLD LICHTWITZ, M.D.LEOPOLD LICHTWITZ, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-10-11-1664 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptIn anemia following bleeding or after the administration of phenylhydrazine, J. H. Pratt and P. Morawitz in 1908 noted an increase in the resistance of the erythrocytes. During the stage of advance of the anemia and during the first period of the restitution of the red cells, the limits of the maximal and minimal fragility were shifted in such a manner that erythrocytes less fragile than normal appeared and the most fragile erythrocytes disappeared. Pratt, in collaboration with S. Itami, continued these studies and found a considerable increase in the volume of the stroma of the erythrocytes during the phase... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: New York, N. Y.*Received for publication March 9, 1937. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 May 1937Volume 10, Issue 11Page: 1664-1668KeywordsAnemiaCellsHemorrhage ePublished: 1 December 2008 Issue Published: 1 May 1937 PDF downloadLoading ...
The rLrp of Mycobacterium tuberculosis inhibits proinflammatory cytokine production and downregulates APC function in mouse macrophages via a TLR2-mediated PI3K/Akt pathway activation-dependent mechanism
Authors: Yuan Liu, Jia-Yun Li, Su-Ting Chen, Hai-Rong Huang, Hong Cai
Journal: Cellular and Molecular Immunology (2015)
c-MYC induces mammary tumorigenesis by means of a preferred pathway involving spontaneous Kras2 mutations
Authors: Celina M. D'Cruz, Edward J. Gunther, Robert B. Boxer, Jennifer L. Hartman, Louis Sintasath, Susan E. Moody, James D. Cox, Seung I. Ha, George K. Belka, Alexander Golant, Robert D. Cardiff, Lewis A. Chodosh
Journal: Nature Medicine (2001)
Marked differences in Betapapillomavirus DNA and antibody prevalence between patients with psoriasis and those with atopic dermatitis
Authors: M.N.C. de Koning, M.C.A. Polderman, T. Waterboer, J. ter Schegget, M.C.W. Feltkamp, M. Pawlita, J.N. Bouwes Bavinck, W.G.V. Quint
Journal: British Journal of Dermatology (2010)

Recent studies revealed that Betapapillomavirus (betaPV) infections are highly prevalent. Skin diseases such as psoriasis, characterized by keratinocyte hyperproliferation, and atopic dermatitis (AD), dominated by cutaneous inflammation, might have an impact on viral life cycle and immune response induction.To investigate whether betaPV infection is different in psoriasis and AD.Twenty-seven patients with psoriasis and 17 with AD were included for betaPV genotyping using eyebrow hairs, and for seroresponse determination.BetaPV DNA was found significantly more often in patients with psoriasis than in those with AD (100% vs. 81%, P=0·022) and the mean number of betaPV types was higher (4·8 vs. 2·1 types, P=0·002). In contrast, the seroprevalence in patients with AD was significantly higher compared with that in patients with psoriasis (88% vs. 56%, P=0·023). Type-specific concordance of serological response to the betaPV type detected in eyebrow hairs was 27% in patients with psoriasis and 47% in those with AD (P=0·019).We speculate that the condition of the skin and the immunological state of the patients have an important impact on the life cycle of betaPV.
Measuring the Effects of Therapy in Parkinson Disease
Authors: Clifford W. Shults, Richard Haas, David Oakes, Karl Kieburtz, Sandra Plumb, Ira Shoulson, M. Flint Beal, Jorge Juncos, John Nutt
Journal: JAMA (2004)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Abstract P3-04-16: Estrogen receptor β agonists reduce breast cancer tumor growth in syngeneic mouse models
Authors: Cathy Samayoa, Naveen K Krishnegowda, Ratna K Vadlamudi, Rajeshwar R Tekmal
Journal: Cancer Research (2015)

Abstract The estrogen receptors (ER) play a significant role in breast cancer, with the majority of breast cancers expressing estrogen receptor alpha (ERα) and depending on its signaling. ERα has proliferative function, however, estrogen receptor beta (ERβ) has anti-proliferative functions. Recently, several selective ERβ agonists have been identified. The objective of this study was to determine the effectiveness of ERβ agonists in inhibiting the growth of distinct breast cancer cells both in-vitro and in-vivo, and to determine the mechanisms involved. The mouse mammary tumor cell lines, D2A1 and MM51, express both ERα and ERβ. Specifically D2A1 cells are dependent on estrogen for growth and have increased expression of aromatase. Additionally, D2A1 cells are very aggressive and highly metastatic; representing a good model of breast cancer progression. MM51 cells are Her2/neu positive and are an adequate model to study the crosstalk between growth factors and ER signaling. Syngeneic mouse tumor models were used to incorporate an intact immune system which plays a role in the tumor’s microenvironment. Our in-vitro studies demonstrate that ERβ agonists significantly inhibit cell growth in a dose dependent manner. Our syngeneic studies show that, in-vivo, ERβ agonists effectively reduce tumor volume and inhibit tumor progression. This study reveals that in addition to acting on ERβ, these agonists reduce the expression of ERα at both the mRNA and protein level, therefore modulating the ratio of ERα to ERβ. Additionally, treatment with ERβ agonists results in increases apoptosis through increased p53 expression, and cell cycle arrest through p27 and cyclin D1. Together, these studies demonstrate the therapeutic potential of ERβ agonists for the treatment of breast cancer. Citation Format: Cathy Samayoa, Naveen K Krishnegowda, Ratna K Vadlamudi, Rajeshwar R Tekmal. Estrogen receptor β agonists reduce breast cancer tumor growth in syngeneic mouse models [abstract]. In: Proceedings of the Thirty-Seventh Annual CTRC-AACR San Antonio Breast Cancer Symposium: 2014 Dec 9-13; San Antonio, TX. Philadelphia (PA): AACR; Cancer Res 2015;75(9 Suppl):Abstract nr P3-04-16.
<i>Untitled, Bronx Storefront, “La Rumba Supermarket”</i>
Authors: Thomas B. Cole
Journal: JAMA (2015)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Abstract 2802: Fine-tuning T cell receptors for adoptive T cell therapy
Authors: Bent Jakobsen
Journal: Cancer Research (2014)

Abstract Adoptive T cell therapy (ACT) with gene-modified T cells is emerging as a highly promising strategy for the treatment of many types of cancer. Therapies associated with the induction of anti-tumor immunity, such as the administration of vaccines or the ex-vivo expansion of patient-derived TILs, have historically had limited success. This lack of efficacy is almost certainly brought about as a consequence of thymic selection, leading to a paucity of T cells, and T cell receptors, in the circulating repertoire, with a sufficient degree of sensitivity towards tumor-associated antigens. An alternative approach, which has generated promising results, relies on the adoptive transfer of patient-derived T cells that have been first modified to express a chimeric antigen receptor (CAR). Nevertheless, a lack of tumor-specific antibody targets limits the wider applicability of CAR T cells. To overcome these issues we have developed a strategy that involves the transfer of T cells expressing engineered TCRs with optimised affinity for a defined tumor antigen. Since TCRs recognize peptide antigens presented on the cell surface in complex with human leukocyte antigen (HLA), they give access to the large pool of intracellular proteins. Furthermore, the use of TCRs means that the natural interaction between a T cell and the corresponding antigen presenting cell is preserved. Importantly, for any given antigen, engineered TCRs require individual optimization, to ensure the appropriate balance between potency and specificity. Recent and emerging clinical data using engineered TCRs for ACT are beginning to corroborate promising pre-clinical findings, with evidence of both potent and durable responses in vivo. However, experiences have also highlighted the dangers of this approach. The main risks associated with TCR adoptive therapy are target presentation on healthy tissue and TCR cross-reactivity to a look-alike peptide. Understanding these risks and ensuring comprehensive and robust safety testing mechanisms are in place is pivotal to mitigate these risks. Citation Format: Bent Jakobsen. Fine-tuning T cell receptors for adoptive T cell therapy. [abstract]. In: Proceedings of the 105th Annual Meeting of the American Association for Cancer Research; 2014 Apr 5-9; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2014;74(19 Suppl):Abstract nr 2802. doi:10.1158/1538-7445.AM2014-2802
Effects of Carcinostatic and Other Biologically Active Compounds in the Normal Rat: Evaluation as a System for Cancer Chemotherapy Screening
Authors: Enrico Anglesio, Erich Hirschberg, Alfred Gellhorn
Journal: Cancer Research (1958)

Summary  The effects of the 27 compounds included in an earlier investigation of diverse systems for cancer chemotherapy screening (4) on the peripheral leukocyte count, the mitotic activity of the small intestinal epithelium, and the bone marrow of normal Wistar rats have been examined. The response of these three normal biological systems differs significantly from that of experimental rodent tumors as a group and from that of either of the two rat tumors tested in the earlier study under essentially the same conditions of treatment. Each of the normal systems also differs from the other two in its response to these compounds.
575. In Vivo Evaluation of Supercoiled Plasmids
Authors: Anthony P. Green, Irina Tumanova, Joseph Burzynski, Dana Rosencrance, Julie White, Jason Scheidel, David Weiner, Jean Boyer
Journal: Molecular Therapy (2005)

Top of pageAbstract
Supercoiled plasmids are an important component of gene-based drugs. Their applications include gene vaccine and gene therapeutic agents or intermediates in the production of recombinant viruses. These applications require very high quality product with low levels of residual contaminants such as genomic DNA, RNA, host protein and endotoxin. While a variety of methods for the production of supercoiled plasmids for clinical applications have been developed, there is no consensus as to the effect of plasmid quality on biological activity.

We have produced two plasmids using four production methodologies based on reversed-phase ion-pairing (PolyFlo) and hydrophobic interaction chromatography, either alone or in tandem processes. The plasmids were analyzed using standard molecular biological techniques as well as more rigorous biophysical techniques. Further, the plasmids were evaluated in vivo in models for gene vaccination and gene therapy. In addition, the gene therapy study included a component to evaluate the degree of plasmid supercoiling and biological activity.

Analysis of the plasmids produced by the four methods showed minimal measurable differences using molecular biological methods. Biophysical characterization revealed more significant differences among the preparations. However, there were significant differences in the in vivo response in both models. In the gene vaccination study, preparations using a tandem process of PolyFlo used in two separation modes provided significantly higher antibody responses to an HIV gag antigen. By contrast, PolyFlo as the single chromatographic step resulted in a significant decrease in the rate of tumor growth when compared to two tandem preparations. These data indicate that the process by which supercoiled plasmids are made can influence biological activity and further that the same process might not be ideal for gene vaccine or gene therapy applications. These data emphasize the need for more rigorous methods to evaluate the biological activity of supercoiled plasmids.
Clear cell papulosis of the skin
Authors: None Y-Y.Lee, None Chao
Journal: British Journal of Dermatology (1998)

Clear cell papulosis is a new entity first described in 1987. To date, six patients have been reported: all were young Taiwanese children. The disease is characterized clinically by multiple small, whitish maculopapules distributed along the milk line and by the presence of large, benign pagetoid cells in the epidermis resembling the clear cell of the nipple. The significance of this entity lies in its potential histogenetic link with Paget's disease of the skin. We report four new Taiwanese patients, three girls and one boy, aged between 21 months and 4 years. Two were sisters. Small hypopigmented macules first appeared on the pubis. They were eventually distributed bilaterally along the milk line but were most numerous in the pubic area. The disease may easily be overlooked when the macules are tiny or few in number and thus display no clear milk‐line distribution, or when they occur in white‐skinned individuals. Histologically, solitary large clear cells with large, round pale nuclei were detected in the basal layer of the hypomelaninized epidermis. The numbers of clear cells varied on haematoxylin and eosin staining and were only small in two patients. The cytoplasm of the clear cells was decorated by antikeratin AE1 and anticarcinoembryonic antigen antibodies. AE1 was the best marker of the clear cell. Some of the AE1‐positive cells were tadpole‐like in shape and were situated well above the basal layer. Ultrastructurally, large clumps of disintegrated or vacuolated mucin granules were present in the cytoplasm of the clear cells. The melanocytes appeared normal; the suprabasal keratinocytes were essentially devoid of melanosomes. The pathological findings in the present study support the hypothesis that these clear cells are an aberrant derivative of sweat gland cells in the epidermis and are potentially the precursor cells giving rise to mammary and extramammary Paget's disease. The differential diagnosis includes chicken pox scars, idiopathic guttate hypomelanosis, hypomelanotic tinea versicolor, anetoderma and early, hypopigmented lesions of Paget's disease.
Searching for new mechanisms of myocardial fibrosis with diagnostic and/or therapeutic potential
Authors: Stephane Heymans, Arantxa González, Anne Pizard, Anna P. Papageorgiou, Natalia López‐Andrés, Frédéric Jaisser, Thomas Thum, Faiez Zannad, Javier Díez
Journal: European Journal of Heart Failure (2015)
Epstein-Barr Virus and Risk of Multiple Sclerosis—Reply
Authors: Neal S. Young, Stephen Rosenfeld
Journal: JAMA (2003)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Laboratory Diagnosis of Immunologic Disorders.
Authors: G. D. Johnson
Journal: Annals of Internal Medicine (1977)

Bacteroides in the genital tract of non- pregnant femalesWe wish to report the preliminary findings of an investigation of the significance of bacteroides infections following gynaeco- logical operations.Ledger et al (1971) considered most postoperative gynaeco- logical infections were endogenous, and recently it has been demonstrated that most of these infections are caused by non- sporing anaerobes, most frequently bac- teroides (Report, 1974).We investigated the carriage of bac- teroides in relation to the stage of the menstrual cycle in two selected groups of non-pregnant females.Patients seen for the first time in the gynaecological out- patients clinic were admitted to group 1, and all patients admitted to the gynaeco- logical ward for elective surgery were admitted to group 2. High vaginal swabs were collected from each patient in both groups; cervical swabs were also collected from patients in group 1.These swabs were sent to the laboratory in transport medium and examined with standard bacteriological methods; Gram-negative obligate anaerobic bacilli which did not produce spores were accepted as Bacter- oides spp.
Inborn Errors of Metabolism
Authors: Hilary J. Vernon
Journal: JAMA Pediatrics (2015)

Inborn errors of metabolism (IEMs) are a large class of genetic disorders characterized by disruption of cellular biochemical functions. Although individual IEMs are rare, collectively they represent a large and diverse class of genetic conditions, with new disorders and disease mechanisms being described regularly. Advances in the understanding of the molecular and biochemical etiologies of many IEMs via modalities such as whole-exome sequencing and metabolomics have led to significant progress in detection and treatment in recent years. In this review, we examine the current state of newborn screening for IEMs, recent advances in therapy for IEMs (including glutaric aciduria type I, urea cycle disorders, mitochondrial disorders, and lysosomal storage disorders), and opportunities for further exploration and discovery.