JEJUNAL BIOPSIES IN SPRUE
Authors: Charles E. Butterworth, Enrique Perez-Santiago
Journal: Annals of Internal Medicine (1958)

Article1 January 1958JEJUNAL BIOPSIES IN SPRUECHARLES E. BUTTERWORTH JR., ENRIQUE PEREZ-SANTIAGO, M.D.CHARLES E. BUTTERWORTH JR.Search for more papers by this author, ENRIQUE PEREZ-SANTIAGO, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-48-1-8 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptHistologic studies of small bowel biopsies in sprue have received very little attention in spite of great interest in various absorptive phenomena. It is well known that the malabsorption syndrome may result from a variety of causes, and in recent years the recognition of such entities as intestinal lipodystrophy, regional enteritis and lymphoma has served to refine the diagnostic criteria for sprue. It may be hoped that further investigation of tissue pathology will lead to a clearer differentiation between the various causes of malabsorption and will contribute to the understanding of absorptive mechanisms.New interest in small bowel pathology was...Bibliography1. Paulley JW: Observations on the aetiology of idiopathic steatorrhea, Brit M. J. 2: 1318 (Dec. 4) 1954. CrossrefMedlineGoogle Scholar2. Bahr PH: A report on researches on sprue in Ceylon 1912-1914, 1915, Cambridge University Press, London. Google Scholar3. Thaysen TE: "Non tropical sprue," 1932, Oxford University Press, London. Google Scholar4. Schein J: Syndrome of non-tropical sprue, Gastroenterology 8: 438, 1947. MedlineGoogle Scholar5. Thin G: Psilosis (Linguae et mucosae intestini), Brit. M. J. 1: 1358-1361 (June 14) 1890. CrossrefGoogle Scholar6. Faber K: Ein Fall chronischer Tropendiarrhoe ("Sprue") mit anatomischer Untersuchung des Digestionstraktus, Arch. f. Verdauungskr. 9: 333, 1904. CrossrefGoogle Scholar7. Justi K: Zur Methodik der Chinindarseichung bei Malaria, Arch. f. Schiffs- u. Tropen-Hyg. 17: 505, 1913. Google Scholar8. MackieFairley FPNH: The morbid anatomy of sprue, Indian J. M. Research 16: 799, 1928-1929. Google Scholar9. Thaysen TE: Pathological anatomy of the intestinal tract in tropical sprue, Tr. Roy. Soc. Trop. Med. and Hyg. 24: 539, 1931. CrossrefGoogle Scholar10. Fairley NH: Tropical sprue with special reference to intestinal absorption, Tr. Roy. Soc. Trop. Med. and Hyg. 30: 9, 1936. CrossrefGoogle Scholar11. SuarezSpiesSuarez RMTDRM: The use of folic acid in sprue, Ann. Int. Med. 26: 643, 1947. LinkGoogle Scholar12. AdlersbergSchein DJ: Clinical and pathologic studies in sprue, J. A. M. A. 134: 1459, 1947. CrossrefMedlineGoogle Scholar13. Hernandez-MoralesNoya FJ cited by Rodriguez-Molina, R. R.: Sprue in the Puerto Rican indigent, Bol. Asoc. méd. de Puerto Rico 32: 187, 1940. Google Scholar14. GardnerPerez-Santiago FHE: Oral absorption tolerance tests in tropical sprue, Arch. Int. Med. 98: 467, 1956. CrossrefGoogle Scholar15. Van der KamerHuininkWeyers JHHtHH: A rapid method for the determination of fat in feces, J. Biol. Chem. 177: 347, 1949. CrossrefMedlineGoogle Scholar16. AlthausenUyeyamaSimpson TLKRG: Digestion and absorption after massive resection of the small intestine. I. Utilization of food from a "natural" versus a "synthetic" diet and a comparison of intestinal absorption tests with nutritional balance studies in a patient with only 45 cm. of small intestine, Gastroenterology 12: 795, 1949. MedlineGoogle Scholar17. AlthausenDoigUyeyamaWeiden TLRKKS: Digestion and absorption after massive resection of the small intestine. II. Recovery of the absorptive function as shown by intestinal absorption tests in two patients and a consideration of compensatory mechanisms, Gastroenterology 16: 126, 1950. CrossrefMedlineGoogle Scholar18. Frazer AC: Disordered gastro-intestinal function and its relationship to tropical sprue, coeliac disease, and idiopathic steatorrhea, Tr. Roy. Soc. Trop. Med. and Hyg. 46: 576, 1952. CrossrefMedlineGoogle Scholar19. LarsenHoffmeyerKielerThaysenThaysenThygesenWulff HHJEHJHPMH: Hunger diarrhoea—famine disease in German concentration camps—complications and sequels, Acta med. Scandinav., Supp. 274, 144: 147-148, 1952. Google Scholar20. Ungley CC: The chemotherapeutic action of vitamin B12 in Vitamins and Hormones, Vol. 13, edited by Harris, R. S., Marrian, G. F., and Thimann, K. V., 1955, Academic Press, New York, p. 189. Google Scholar21. Faber K: Lectures on internal medicine, 1927, Hoeber & Co., New York. CrossrefGoogle Scholar22. Bizzozero G: Über die Regeneration der Elemente der Schlauchformigen Drusen und des Epithels des Magendarmkanals, Anat. Anz. 3: 781, 1888. Google Scholar23. Friedman NB: Cellular dynamics in the intestinal mucosa: the effect of irradiation on epithelial maturation and migration, J. Exper. Med. 81: 553, 1945. CrossrefMedlineGoogle Scholar24. LeblondStevensBogoroch CPCER: Histological localization of newlyformed desoxyribonucleic acid, Science 108: 531, 1948. CrossrefMedlineGoogle Scholar25. LeblondWalker CPBE: Renewal of cell populations, Physiol. Rev. 36: 255, 1956. CrossrefMedlineGoogle Scholar26. DetrickUphamHighbyDebleyHaley LEHCDVTJ: Influence of x-ray irradiation on glucose transport in the rat intestine, Radiation Research 2: 483, 1955. CrossrefMedlineGoogle Scholar27. Bullough WS: Hormones and mitotic activity, in Vitamins and Hormones, Vol. 13, edited by Harris, R. S., Marrian, G. F., and Thimann, K. V., 1955, Academic Press, New York, p. 262. Google Scholar28. GoodmanGilman LSA: The pharmacological basis of therapeutics, 2nd Ed., 1955, The Macmillan Co., New York. Google Scholar29. Gardner FH: Observations on the cytology of gastric epithelium in tropical sprue, J. Lab. and Clin. Med. 47: 529, 1956. MedlineGoogle Scholar30. GrahamRheault RMMH: Characteristic changes in epithelial cells in pernicious anemia, J. Lab. and Clin. Med. 43: 235, 1954. MedlineGoogle Scholar31. Rubin CE: The diagnosis of gastric malignancy in pernicious anemia, Gastroenterology 29: 563, 1955. CrossrefMedlineGoogle Scholar32. Shiner M: Jejunal-biopsy tube, Lancet 1: 85 (Jan. 14) 1956. CrossrefGoogle Scholar33. MilanésLeónCausa FPA: Jejunum histopathological studies through surgical biopsy in a case of tropical sprue in relapse, Rev. Gastroenterol. 18: 182, 1951. MedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Hato Rey, Puerto Rico*From the Symposium on Diseases of Intestinal Absorption, presented at the Thirty-eighth Annual Session of The American College of Physicians, Boston, Massachusetts, April 9, 1957.From the Tropical Research Medical Laboratory, San Juan, Puerto Rico.Requests for reprints should be addressed to Commanding Officer, U. S. Army Tropical Research Medical Laboratory, APO 851, New York, N. Y. 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FLOCH, M.D.Enteritis due toStrongyloides stercoralisThe Celiac SyndromeAbnormalities of the small intestinal mucosa in Crohn's Disease (regional enteritis)Tropical Sprue and Vitamin B 12Light- and electron-microscope studies of the effects of 4-aminopteroylglutamic acid (aminopterin) on the mucous membrane of the small intestine of the ratIntestinal Absorption and MalabsorptionIntestinal Absorption — Aspects of Structure, Function and Disease of the Small-Intestine MucosaSucrase activity in the intestinal mucosa of patients with sprue and normal subjectsPROTEIN-LOSING ENTEROPATHY IN THE SPRUE SYNDROMEHistological Changes in the Duodenal Mucosa in Coeliac Disease: Reversibility During Treatment with a Wheat Gluten Free DietPrimary Carcinoma of the Jejunum with Atrophic Jejunitis and Intestinal MalabsorptionAn Electron Microscopic Investigation of the Jejunal Epithelium in SprueJEJUNAL BIOPSY IN ADULT CŒLIAC DISEASE AND ALLIED DISORDERSHistopathologic Studies in SteatorrheaHematologic Aspects of SprueVITAMIN-A DEFICIENCY FOLLOWING TOTAL GASTRECTOMYStudies of Celiac DiseaseThe effect of aminopterin on the absorption of xylose from the rat small intestineALIMENTARY HISTOLOGY IN THE MALABSORPTION SYNDROME FOLLOWING PARTIAL GASTRECTOMYSome Observations on the Malabsorption Syndrome, Based on the Use of Absorption Tests and Biopsy of the Small IntestineCase 44362Tropical Sprue 1 January 1958Volume 48, Issue 1Page: 8-29KeywordsBiopsyEdemaEnteritisInflammationLipodystrophyLymphomaMegaloblastic anemiaMucous membranesResearch laboratories ePublished: 1 December 2008 Issue Published: 1 January 1958 PDF downloadLoading ...