GAUCHER'S DISEASE AND PREGNANCY: TWO CASE REPORTS, INCLUDING OBSERVATIONS ON THE EFFECTS OF ADRENAL STEROIDS
Authors: Barry Decker, C. A. Mcwhorter
Journal: Annals of Internal Medicine (1956)

Case Reports1 June 1956GAUCHER'S DISEASE AND PREGNANCY: TWO CASE REPORTS, INCLUDING OBSERVATIONS ON THE EFFECTS OF ADRENAL STEROIDSBARRY DECKER, C. A. MCWHORTER, M.D.BARRY DECKERSearch for more papers by this author, C. A. MCWHORTER, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-44-6-1219 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptGaucher's disease is a rare hereditary1, 2, 3error in the intracellular metabolism4, 5, 6of cerebroside resulting in the accumulation of glucose-cerebroside or polycerebroside7in a swollen, distinctive reticuloendothelial cell bearing the name of the disease. In adults these cells accumulate in the spleen, liver, visceral lymph nodes and bone marrow. The typical manifestations of the disease are splenomegaly, hepatomegaly, pallor, pingueculae, symmetric pigmentation, myopia, a panhemocytopenia associated with a bleeding tendency,8, 9and painful bone changes sometimes resulting in joint deformity or pathologic fractures.10The disease has been demonstrated, however, in cases lacking some or all of the...Bibliography1. Groen J: Hereditary mechanism of Gaucher's disease, Blood 3: 1238, 1948. CrossrefMedlineGoogle Scholar2. GordonKaufman WHJM: Gaucher's disease, J. Michigan M. Soc. 49: 785, 1950. MedlineGoogle Scholar3. HerndonBender CNJR: Gaucher's disease: cases in 5 related Negro siblings, Am. J. Human Genet. 2: 49, 1950. MedlineGoogle Scholar4. OttensteinSchmidtThannhauser BGSJ: Studies concerning the pathogenesis of Gaucher's disease, Blood 3: 1250, 1948. CrossrefMedlineGoogle Scholar5. SacksAndersch MSMA: Isolation of glucose containing cerebroside from the spleen in Gaucher's disease, Am. J. M. Sc. 212: 546, 1946. 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AdlerMaybaum ES: Rare features of Gaucher's disease, Ann. Rheumat. Dis. 13: 229, 1954. CrossrefMedlineGoogle Scholar15. MooreColey MBL: Bone lesions in Gaucher's disease, J. Tennessee M. A. 40: 101, 1947. Google Scholar16. Kulowski J: Gaucher's disease in bone, Am. J. Roentgenol. 63: 840, 1950. Google Scholar17. KrobothJohnson FJEW: Osseous Gaucher's, S. Clin. North America 32: 1141, 1952. CrossrefGoogle Scholar18. Logan VW: Results of splenectomy in Gaucher's disease, Surg., Gynec. and Obst. 72: 807, 1941. Google Scholar19. Tennet W: Gaucher's disease—early roentgenological diagnosis, Brit. J. Radiol. 18: 356, 1945. CrossrefGoogle Scholar20. Elliott JF: Gaucher's disease and pregnancy, Canad. M. A. J. 66: 166, 1952. MedlineGoogle Scholar21. BrombergToaffDiengott YMRD: Pregnancy and Gaucher's disease, Brit. M. J. 2: 761, 1953. CrossrefMedlineGoogle Scholar22. Logan WP: Gaucher's disease with thrombocytopenia and pregnancy, J. Florida M. A. 40: 320, 1953. MedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: *Received for publication August 29, 1955.From the Medical Service, 3902nd USAF Hospital, Offutt Air Force Base, Nebraska, and the Department of Pathology, University of Nebraska, College of Medicine.†Consultant Pathologist to the 3902nd USAF Hospital and Associate Professor of Pathology, University of Nebraska. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byThe female Gaucher patient: The impact of enzyme replacement therapy around key reproductive events (menstruation, pregnancy and menopause)Gaucher's disease with myocardial involvement in pregnancyGaucher's Disease in PregnancyObstetric aspects of Gaucher diseaseThe Genetic Mechanism of Gaucher's Disease,THE OCCURRENCE OF INTRACELLULAR IRON IN GAUCHER'S DISEASE*†MORTIMER LORBER, M.D.Gaucher's disease in pregnancyGaucher's DiseaseGAUCHER'S DISEASE IN IDENTICAL TWINS*RICHARD I. CRONE, JAMES J. BERGINDie SphingolipoidosenLiteratur 1 June 1956Volume 44, Issue 6Page: 1219-1230KeywordsAnemiaBirthGenetic diseasesHemorrhageHospital medicineInfantsSpleenSplenomegalySteroidsThrombocytopenia ePublished: 1 December 2008 Issue Published: 1 June 1956 PDF downloadLoading ...