SEVERE SPONTANEOUS HYPERSENSITIVITY TO HEPARIN
Authors: A GOTZ
Journal: Annals of Internal Medicine (1951)

Case Reports1 October 1951SEVERE SPONTANEOUS HYPERSENSITIVITY TO HEPARINALEXANDER GOTZ, M.D.ALEXANDER GOTZ, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-35-4-919 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptIn recent years, heparin has found wide clinical use as an effective agent in the prevention and treatment of thromboembolic disease.Heparin is a complex organic substance containing chondroitinsulfuric acid and small amounts of protein (1 to 2 per cent).1 It is usually obtained from beef liver or lung. It would therefore seem quite likely that a fairly large number of cases of sensitivity to this substance would be encountered in clinical practice. Surprisingly, however, the literature contains comparatively few reports of heparin sensitivity.Jorpes2mentioned four cases in his comprehensive monograph, without going into detail about them. Hojensgard and...Bibliography1. Jorpes E: Personal communication. Google Scholar2. Jorpes E: Heparin in the treatment of thrombosis, 2nd Ed., 1946, Oxford, New York, p. 165. Google Scholar3. HojensgardSchwartz ICM: Heparin hypersensitivity, Acta Allergologica 2: 7, 1949. CrossrefGoogle Scholar4. GrolnickLoewe ML: Report of sensitivity to heparin in patient, J. Allergy 18: 277, 1947. CrossrefMedlineGoogle Scholar5. LevyMcKrill LN: Results in the treatment of subacute bacterial endocarditis, Arch. Int. Med. 77: 367, 1946. CrossrefGoogle Scholar6. CrockettRhoads KAPS: Hyperthermia caused by penicillin-heparin in the treatment of subacute bacterial endocarditis, Ann. Int. Med. 28: 456, 1948. LinkGoogle Scholar7. DeTakats G: Thrombo-embolism, J. internat. chir. 8: 903, 1948. Google Scholar8. CortesGrolnickLoewe JLML: Anaphylactogenic properties of heparin in guinea pigs, J. Allergy 18: 196, 1947. CrossrefMedlineGoogle Scholar9. Gregoire C: Influence de l'heparine sur les réactions d'anaphylactie cutanée, Arch. internat. de pharmacodyn. et de thérap. 72: 76, 1946. MedlineGoogle Scholar10. Jorpes E: See reference 2, p. 55. Google Scholar11. Giordano AF: Association of histamine with acetylcholine and heparin in the treatment of allergies, Día méd. 19: 848, 1947. MedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Ann Arbor, Michigan*Received for publication April 21, 1950.From the Medical Service, St. Joseph's Mercy Hospital, Ann Arbor, Michigan. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited bySevere Reactions During HemodialysisLow- Versus High-Dose Heparin in the Treatment of Pulmonary EmbolismKrankheiten der GefäßeZur Frage der Anticoagulantientherapie des HerzinfarktesAntikoagulantiaZur Frage der Anticoagulantientherapie des Herzinfarktes 1 October 1951Volume 35, Issue 4Page: 919-922KeywordsAllergy and immunologyGratitudeHeparinHospitalsHypersensitivityLiverLungsMedical servicesProteins ePublished: 1 December 2008 Issue Published: 1 October 1951 PDF downloadLoading ...