A Case of Apical Ballooning Cardiomyopathy Associated with Duloxetine
Authors: Benjamin R. Bergman, Harmony R. Reynolds, Adam H. Skolnick, Demetrio Castillo
Journal: Annals of Internal Medicine (2008)

Letters5 August 2008A Case of Apical Ballooning Cardiomyopathy Associated with DuloxetineBenjamin R. Bergman, MD, Harmony R. Reynolds, MD, Adam H. Skolnick, MD, and Demetrio Castillo, MDBenjamin R. Bergman, MDFrom New York University School of Medicine, New York, NY 10016., Harmony R. Reynolds, MDFrom New York University School of Medicine, New York, NY 10016., Adam H. Skolnick, MDFrom New York University School of Medicine, New York, NY 10016., and Demetrio Castillo, MDFrom New York University School of Medicine, New York, NY 10016.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-149-3-200808050-00021 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail Background: Catecholamine level surges may be associated with myocardial dysfunction, as observed in cases of septic shock, subarachnoid hemorrhage, respiratory failure, and pheochromocytoma (1, 2). Selective serotonin reuptake inhibitors have catecholaminergic activity but generally little cardiovascular toxicity. Duloxetine, a combined norepinephrine and selective serotonin reuptake inhibitor, has not been reported to have any major cardiovascular toxicity.Objective: To report a case of transient apical ballooning cardiomyopathy associated with duloxetine use.Case Report: A 60-year-old Hispanic woman presented with 5 days of dizzy spells and 1 day of chest discomfort. Electrocardiography showed ST-segment elevations and T-wave inversions, and serum troponin I ...References1. Mootha VK, Feldman J, Mannting F, Winters GL, Johnson W. Pheochromocytoma-induced cardiomyopathy. Circulation. 2000;102:11-3. [PMID: 10880429] CrossrefMedlineGoogle Scholar2. Sharkey SW, Shear W, Hodges M, Herzog CA. Reversible myocardial contraction abnormalities in patients with an acute noncardiac illness. Chest. 1998;114:98-105. [PMID: 9674454] CrossrefMedlineGoogle Scholar3. Wittstein IS, Thiemann DR, Lima JA, Baughman KL, Schulman SP, Gerstenblith G, et al. Neurohumoral features of myocardial stunning due to sudden emotional stress. N Engl J Med. 2005;352:539-48. [PMID: 15703419] CrossrefMedlineGoogle Scholar4. Thase ME, Tran PV, Wiltse C, Pangallo BA, Mallinckrodt C, Detke MJ. Cardiovascular profile of duloxetine, a dual reuptake inhibitor of serotonin and norepinephrine. J Clin Psychopharmacol. 2005;25:132-40. [PMID: 15738744] CrossrefMedlineGoogle Scholar5. Glueck CJ, Khalil Q, Winiarska M, Wang P. Interaction of duloxetine and warfarin causing severe elevation of international normalized ratio [Letter]. JAMA. 2006;295:1517-8. [PMID: 16595756] CrossrefMedlineGoogle Scholar6. Package insert. Imitrex, Glaxo Wellcome. Google Scholar Author, Article, and Disclosure InformationAffiliations: From New York University School of Medicine, New York, NY 10016.Disclosures: None disclosed. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByTakotsubo Cardiomyopathy and Intraoperative Cardiac Arrest: Is Desvenlafaxine a Contributing Factor?Drug-Induced Takotsubo CardiomyopathySerotonin norepinephrine re-uptake inhibitor (SNRI)-, selective norepinephrine reuptake inhibitor (S-NRI)-, and exogenously administered norepinephrine-induced takotsubo syndrome: Analysis of published casesThe Use of Fluoxetine in a Patient With Takotsubo CardiomyopathyDuloxetineAutonomic Findings in Takotsubo CardiomyopathyShort answer question: a distracting ECGTakotsubo Syndrome (or Apical Ballooning Syndrome) Secondary to ZolmitriptanTako-Tsubo Cardiomyopathy Following Modafinil UseDrug-induced Takotsubo CardiomyopathyOccurrence of Tako-Tsubo Cardiomyopathy in Association with Ingestion of Serotonin/Noradrenaline Reuptake InhibitorsDuloxetine-Induced Tako-Tsubo Cardiomyopathy"Tako-Tsubo" Cardiomyopathy and Duloxetine UseAntidepressant drugsTakotsubo cardiomyopathy — The current state of knowledgeAdverse events, toxicity and post-mortem data on duloxetine: Case reports and literature surveyDuloxetineCardiogenic shock associated with reversible dilated cardiomyopathy during therapy with regular doses of venlafaxine 5 August 2008Volume 149, Issue 3Page: 218-219KeywordsAngiographyCardiomyopathiesCatecholaminesCoronary arteriesElectrocardiographyEmotionsNorepinephrineThoraxToxicity ePublished: 5 August 2008 Issue Published: 5 August 2008 CopyrightCopyright © 2008 by American College of Physicians. All Rights Reserved.PDF DownloadLoading ...