tbuckley/cabot-search huggingface dataset:
Abstract 2720: <i>In vitro</i> evaluation of a novel chemotherapeutic agent, NecroX-7, in human Burkitt lymphoma cells
Authors: Eun- Jung Kim, Eun Sol Lee, Keon- Il Im, Soon H. Kim, Jung- Yeon Lim, Nayoun Kim, Seok- Goo Cho
Journal: Cancer Research (2014)

Abstract NecroX-7 is a novel small molecule of the NecroX series, its chemical compound is C25H32N4O4S2 with molecular weight 516.67 based on the indole-moiety. It prevents from oxidative stress-induced cell death. NecroX-7 prevented the release of HMGB1 or ameliorated hepatic IR injury. It is shown that NecroX-7 can inhibit NAPDH oxidase activity and osteoclast differentiation. Furthermore, NecroX-7 protected against APAP-induced hepatic injury by directly binding to NAPQI. However, the function and the underlying mechanisms of NecroX-7 in cancer cell growth have not been well established. This study was aimed at evaluating the efficacy as anticancer agent in human lymphoma cells. Human Burkitt lymphoma cell lines were treated NecroX-7 in vitro. The effects of NecroX-7 treatment were evaluated using MTS assay for cell viability and annexin-V/propidium iodide labeling for apoptosis. Cell cycle was analyzed by Flow cytometry. Western blotting was used to look for NecroX-7 induced protein changes. As results, NecroX-7 treatment efficiently inhibited cell growth at dose- and time- dependent and induced apoptosis in cell lines. Apoptosis was showed by accumulation of annexin-V and PI-positive cells, caspase-3 activation and induction of PARP cleavage. The IC50 values of NecoX-7 in cell lines were around 50 uM. NecroX-7 induced G2/M phase cell cycle arrest in Ramos and Daudi cells.These results suggest that NecroX-7 is a potential anticancer agent for treatment of human Burkitt lymphoma cells and provide a rational for preclinical and clinical evaluation of NecoX-7 for lymphoma therapy. Citation Format: Eun- Jung Kim, Eun Sol Lee, Keon- Il Im, Soon Ha Kim, Jung- Yeon Lim, Nayoun Kim, Seok- Goo Cho. In vitro evaluation of a novel chemotherapeutic agent, NecroX-7, in human Burkitt lymphoma cells. [abstract]. In: Proceedings of the 105th Annual Meeting of the American Association for Cancer Research; 2014 Apr 5-9; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2014;74(19 Suppl):Abstract nr 2720. doi:10.1158/1538-7445.AM2014-2720
Abstract 14653: Periprocedural Transfusion is Associated With a Dramatic Increase in Morbidity and Mortality in Patients Undergoing Percutaneous Vascular Interventions: Insights From the The Bmc2-vic
Authors: Peter Henke, Yeo June Park, Paul Bove, Robert Cuff, Andris Kazmers, Sachinder Hans, Htinder Gurm, Paul M Grossman
Journal: Circulation (2014)

Objective: Blood transfusions are common among patients undergoing vascular interventions. The impact of transfusion on patients undergoing vascular percutaneous interventions has been poorly defined. Methods: We examined data from a large multicenter (n=44 hospitals) quality improvement (QI) vascular interventional registry of all patients undergoing percutaneous vascular interventional (PVI) procedures for peripheral arterial disease (PAD) between 2010 and 2013. Multiple logistic regression modeling was used to identify predictors of, and effect of transfusion on outcomes. Results: Of the 18,127 patients enrolled in the registry, 4.1% received a blood transfusion. The median hemoglobin of those transfused was 7.7 mg/dL (IQR =7.2 - 8.4). Transfusion rates varied from 0 to 14% amongst the hospitals in the registry. From a logistic regression model for transfusion (C-statistic = 0.84 and Hosmer-Lemeshow P-value = 0.653), significant factors (all p<.01) that were independently associated with transfusion in...
Abstract P435: Body Fatness, Cardiorespiratory Fitness And Inflammatory Markers In Adolescents
Authors: Carla Moreira, Sandra Abreu, Paula C Santos, Luis Lopes, Jorge Mota, Rute Santos
Journal: Circulation (2014)

Introduction: The alarming increase in obesity worldwide and the decrease in cardiorespiratory fitness (CRF) levels among adolescents are of concern in the development of cardiovascular diseases. Therefore, the purpose of this study was to evaluate the association between body fatness, CRF, and inflammatory markers [C-reactive protein (C-RP), interleukin-6 (IL-6), tumor necrosis factor alpha (TNF-α), and leptin] in a sample of Portuguese adolescents. Hypothesis: We assessed the hypothesis that adolescents with higher body fatness and lower CRF levels will have an increased level of inflammatory markers. Methods: A cross-sectional school-based study was conducted on 529 Portuguese adolescents (268 girls) aged 12-18 years (mean age 14.3±1.7). Body fatness (BF) was assessed using the Bioelectric Impedance Analysis. Intravenous blood samples were taken after an overnight fast to determine inflammatory markers (C-RP, IL-6, TNF-α, and leptin). CRF was measured with the 20m-Shuttle-Run-Test from the Fitnessgram battery test as number of laps. Pearson correlation was used for bivariate associations between BF, CRF and inflammatory markers. Linear regression analyses were used to examine the association between BF, CRF and inflammation markers with adjustments for age and sex. Results: Pearson’s correlation analyses, adjusted for age and sex, revealed that BF was positively correlated with leptin (r=0.640, P &lt;0.001) and C-RP (r=0.235, P &lt;0.001), and negatively correlated with CRF (r= -0.473, P &lt;0.001) whereas CRF was inversely correlated leptin (r= -0.420, P &lt;0.001) and C-RP (r= –0.226, P &lt;0.001). Among the inflammatory markers leptin (β= 0.188, p&lt;0.001) and C-RP (β= 0.030, p&lt;0.05) were positively associated with BF whereas leptin (β= -0,160, p&lt;0.001) and C-RP (β= -0.56, p&lt;0.001) were inversely associated with CRF, conversely, TNF-α (β= 0.118, p&lt;0.05) showed a positive association with CRF. No associations were found between BF, CRF and IL-6. Conclusions: Our findings emphasize the importance of increasing CRF levels and decrease body fatness among adolescents in order to prevent metabolic abnormalities predisposed to or associated inflammation and thus contribute to the prevention of cardiovascular diseases later in life.
The effect of house dust mite impermeable covers and an acaricide on Der P 1 levels
Authors: S.G.M. Cloosterman, I.D. Bijl-Hofland, S. van der Heide, B. Brunekreef, F.J.J. van den Elshout, H.T.M. Folgering, C.P. van Schayck
Journal: European Respiratory Journal (1998)
Abstract 17983: Ankle-Brachial Index Predicts Progression of Aortic Stiffeness
Authors: Zi Ye, Coutinho Thais, Iftikhar Kullo
Journal: Circulation (2014)

Background: Arterial stiffness is associated with increased risk for adverse cardiovascular outcome. Ankle-brachial index (ABI) is a measure reflective of systemic atherosclerosis. Whether it can predict central aortic stiffness and its progression is unknown. As such, we investigated the impact of ABI on carotid-femoral pulse wave velocity (cfPWV) and aortic characteristic impedance (Z c ) in apparently healthy adults from the community. Methods: Participants were from the GENOA study without cardiovascular disease at baseline (December 2000 to September 2006) and completed follow-up (September 2009 to December 2012) assessment (n=358, 63%women, 69% hypertensive). ABI was measured by standard protocol at baseline. cfPWV was measured by applanation tonometry. Difference in log-cfPWV between two visits ([[Unable to Display Character: &amp;#8710;]]log-cfPWV) was used to estimate progression of aortic stiffness. Z c was ascertained at 2 nd visit using carotid tonometry followed by echocardiography (Cardiovascular Engineering Inc., Norwood). Results: After a mean follow-up of 8.5±0.9 years, cfPWV increased from 9.3±2.4m/s to 11.1±5.0m/s. After adjusted for age, sex and time-interval between two visits, lower ABI was associated with greater [[Unable to Display Character: &amp;#8710;]]log-cfPWV (β±SE:-0.41±0.15), and increased risk for higher log-cfPWV (β±SE:-0.38±0.12) and higher log-Z c at 2 nd visit (β±SE:-0.38±0.18) (all P≤0.04). Diabetes and renal function at baseline were predictors for higher cfPWV and Z c ; hypertension and metabolic syndrome were only predictors of cfPWV; while age and male gender were major predictors for [[Unable to Display Character: &amp;#8710;]]log-cfPWV (all P≤0.04). The association of ABI with cfPWV or Z c remained significant after adjustment for these covariates (both P&lt;0.05). Greater [[Unable to Display Character: &amp;#8710;]]log-cfPWV was associated with increased risk for higher log-Z c ; longer time-interval amplified this effect (both p for [[Unable to Display Character: &amp;#8710;]]log-cfPWV and [[Unable to Display Character: &amp;#8710;]]log-cfPWV x time-interval ≤0.03). Conclusions: Lower ABI predicts progression of aortic stiffness, leading to both increased aortic wall stiffness (PWV) and greater aortic area-flow mismatch (Z c ), suggesting the impact of subclinical atherosclerosis on proximal aortic stiffening.
RISK FACTORS FOR DEATH IN TREATED HYPERTENSIVE PATIENTS
Authors: C.J. Bulpitt, P. Clifton, C.T. Dollery, G.S. Harper, L.J. Beilin, E.C. Coles, J.S.S. Gear, B.F. Johnson, A.D. Munro-Faure
Journal: The Lancet (1979)
Abstract 911: Lacking SOCS3 Gene in Macrophages Prevents the Development of Atherosclerosis in ApoE Deficient Mice
Authors: Tomoka Yamamoto, Hideo Yasukawa, Mitsuhisa Koga, Yusuke Sugi, Daisuke Fukui, Nobuyoshi Futamata, Nobuhiro Tahara, Hisashi Kai, Tsutomu Imaizumi
Journal: Circulation (2007)

Background : Atherosclerosis is now generally accepted as a chronic inflammatory disease characterized by accumulation of blood-derived macrophages in the arterial wall. It has been shown that suppressor of cytokine signaling 3 (SOCS3) is an intrinsic negative regulator of interleukin-6 (IL-6)-STAT3 signaling that plays an essential role in inflammatory response. In the present study, we determined whether STAT3-mediated IL-6 signaling and SOCS3 within the macrophages would play an important role in the development of atherosclerosis. Methods and Results : We examined the activation of STAT3 and expressions of IL-6 family cytokines and SOCS3 in the aorta of apolipoprotein E knockout mice (ApoE-KO) and control mice by western blot, immunohistochemical staining and RT-PCR. Western blot revealed that STAT3 is phosphorylated in the atherosclerotic lesions from ApoE-KO mice but not in those from control mice. Dual immunohistochemical staining revealed that phosphorylated STAT3 and macrophage marker, MOMA2, were co-expressed in the atherosclerotic plaque in ApoE-KO deficient mice, suggesting that the STAT3 signaling pathway within the macrophages was activated in atherosclerosis. Next, to investigate the role of STAT3-mediated IL-6 signaling and SOCS3 in macrophages during atherogenesis, we created ApoE-KO mice with a macrophage-restricted deletion of SOCS3 gene (ApoE/SOCS3-KO). We found that atherosclerotic lesion area by oil-red O staining was significantly reduced in ApoE/SOCS3-KO (n=17) compared with control ApoE-KO mice (n=13) (4.63±0.43 vs. 8.29±0.50 %, p&lt;0.01). In in vitro analyses, enzyme-linked immunosorbent assay revealed that LPS-induced TNF-alpha production were significantly smaller in SOCS3 deficient macrophages compared with wild type macrophages (n=8, 2238±155 vs. 992±83 pg/ml, p&lt;0.01). Also we found that IL-6-induced oxidized-LDL uptake was 42% reduced in SOCS3 deficient macrophages compared with wild type macrophages (p&lt;0.01). Conclusion: Our data show that the deletion of SOCS3 in macrophages prevents the development of atherosclerosis in mice, possibly by inhibiting the inflammatory cytokine production and oxidized-LDL uptake in macrophages.
Phytoestrogen exposure, polymorphisms in COMT, CYP17, CYP19, EDH17B2, ESR1 and SHBG genes and sex hormone levels among postmenopausal women in EPIC-Norfolk
Authors: Yen-Ling Low, Mitch Dowsett, Alison Dunning, Sheila Bingham
Journal: Cancer Research (2005)

Proc Amer Assoc Cancer Res, Volume 46, 2005

2553 

Phytoestrogens have been hypothesised to lower breast cancer risk through stimulating sex hormone-binding globulin (SHBG) production and inhibiting enzymes involved in estrogen biosynthesis and metabolism, thus lowering levels of circulating estradiol. In this large cross-sectional study, we investigated the relationship between phytoestrogen exposure and plasma estradiol and SHBG levels in postmenopausal women and their relation with polymorphisms in relevant genes. Subjects consisted of 1743 free-living healthy postmenopausal women in the Norfolk arm of the European Prospective Investigation into Cancer and Nutrition (EPIC) study. We have previously shown that urinary phytoestrogen levels correlated strongly with serum phytoestrogen levels (R=0.81 to 0.91, p<0.001) and can serve as suitable dietary biomarkers (1) . Urinary levels of 7 phytoestrogens (daidzein, genistein, glycitein, O-desmethylangolensin (O-DMA), equol, enterodiol and enterolactone) were analysed by liquid chromatography/tandem mass spectrometry and used as biomarkers for dietary phytoestrogen intake. Twelve single nucleotide polymorphisms (SNPs) in the COMT, CYP17, CYP19, EDH17B2, ESR1 and SHBG genes were genotyped using end-point Taqman assays. Plasma estradiol and SHBG were measured by immunoassays. Adjusting for age and body mass index, urinary O-DMA was positively correlated with plasma estradiol (R=0.050, p=0.037), with a stronger correlation found in the 487 women with TT genotype for ESR1 PvuII polymorphism (R= 0.133, p=0.003). The positive correlation observed in women as a whole became no longer significant when we excluded women with ESR1 PvuII TT genotype, indicating that the correlations observed were due mainly to this group of women. Adjusting for age and body mass index, urinary equol was negatively correlated with plasma estradiol (R= -0.060, p=0.013) and urinary enterolactone was positively correlated with plasma SHBG (R=0.110, p<0.001). Even in Western populations with low habitual soy consumption, phytoestrogen exposure exerts modest effects on plasma estradiol and SHBG levels in postmenopausal women and diet-gene interactions may be involved. Grant support: UK Medical Research Council, UK Food Standards Agency, Cancer Research UK and the Agency for Science, Technology and Research, Singapore . Reference 1. Grace PB, Taylor JI, Low Y-L, Luben RN, Mulligan A, Botting NP, et al. Phytoestrogen concentrations in serum and spot urine as biomarkers for dietary phytoestrogen intake and their relation to breast cancer risk in European Prospective Investigation of Cancer and Nutrition-Norfolk. Cancer Epidemiol Biomarkers Prev 2004;13:698-708.
SSVEP stimuli design for object-centric BCI
Authors: Pierre Gergondet, Abderrahmane Kheddar
Journal: Brain-Computer Interfaces (2015)

In order to design brain-computer interface applications based on steady-state visually evoked potentials (SSVEP), one has to decide on the shape, the attributes and the way the SSVEP stimuli are to be displayed to the user. This choice is generally driven by the tasks to achieve and, eventually, the complexity of the systems to be controlled. An ‘object-affordance centric’ approach consists in ﬂickering objects of interest that appear in the ﬁeld of view of the user during video feedback, e.g. provided by a robotic surrogate embedded with cameras. Processing of the video images automatically recognizes objects of interest that are in the user’s ﬁeld of view. These are overlapped with graphical icons that ﬂicker at different frequencies to be recognized by the SSVEP-BCI classiﬁer. This study investigates selected graphical and rendering practices that affect the strength of the SSVEP to produce the highest performance during BCI operations.
Tuberculosis of the Gall Bladder
Authors: James T. Case
Journal: Annals of Internal Medicine (1928)

Article1 January 1928Tuberculosis of the Gall BladderJAMES T. CASEJAMES T. CASESearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-1-7-482 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTuberculosis of the gall-bladder is one of the rarest of pathological findings. The older text-books either make no mention of it at all, or ascribe to it a hypothetical great rarity without any reference to actually observed cases. Although tuberculosis of the liver and of the intrahepatic biliary passages is no great rarity, and although the researches of many writers (Fraenkel and Krause, Joest and Ernshoff, Rabinowitsch, Calmettee and Guerin, etc.) have shown the frequent presence of living tubercle bacilli in the bile of the gall-bladder in cases of tuberculosis, both with and without involvement of the liver, the relative...Bibliography SIMMONDS : Centralbl. f. allg. Path. u. Anat., 1908, xix, 225; Műnch. med. Wochenschr., 1908, LV, 1049. (Cites cases of Heddäus, Kisch, Schmidt and Beitzke.) Google Scholar DEYCKE : Sitzung d. biol. Section, Hamburg, 1908; Ref. Műnch. med. Wochenschr. Google Scholar KNOTTE : Inaug. Dissert, Leipzig, 1907. Google Scholar GAUCHER : Bull. de la Soc. d'Anatomie, 1879, 515. Google Scholar CASEWARTHIN : Transactions of Western Surgical Assoc., 1925, 171. Google Scholar RANKINMASSIE : Annals of Surgery, 1926, LXXXVI, 800. CrossrefGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Battle Creek, Michigan*From the Surgical Clinic of the Battle Creek Sanitarium, Battle Creek, Michigan. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited by�ber Tuberkulose der Gallenblase 1 January 1928Volume 1, Issue 7Page: 482-493KeywordsBileBladderLiver ePublished: 1 December 2008 Issue Published: 1 January 1928 PDF downloadLoading ...
THE INTEGRATIVE ACTION OF THE ENDOCRINE SYSTEM
Authors: J H MEANS
Journal: Annals of Internal Medicine (1951)

Article1 June 1951THE INTEGRATIVE ACTION OF THE ENDOCRINE SYSTEMJ. H. MEANS, M.D., F.A.C.P.J. H. MEANS, M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-34-6-1311 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptFirst, may I express my thanks for the honor you have done me in asking me to give your Harvard Lecture. For subject I have chosen certain aspects of the fundamental question, "What makes us tick?""What makes us tick as human beings" is perhaps relatively easy to answer. We might say the cerebral cortex or, if you prefer, the soul of man. The latter, however, gets us into theology, and I would prefer to stay out of that—at least at this time. "What makes us tick as animals" is a more complicated question. There is involved not only our... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Boston, Massachusetts*Received for publication January 5, 1951.Third annual Harvard Lecture given at the University of Colorado Medical Center, December 8, 1950, under the auspices of the Rocky Mountain Harvard Medical Alumni Association.†Jackson Professor of Clinical Medicine, Harvard University, and Chief of the Medical Services, Massachusetts General Hospital. Nextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byPhysical Training Helps to Regulate and Improve Glandular Functions: A Review of Research 1 June 1951Volume 34, Issue 6Page: 1311-1323KeywordsAlumniEndocrine systemHospital medicineMedical servicesTicks ePublished: 1 December 2008 Issue Published: 1 June 1951 Copyright & PermissionsCopyright, 1951, by The American College of PhysiciansPDF downloadLoading ...
Abstract 17973: Biomass Fuel Use is Associated With Elevated Blood Pressure and Hypertension Status in Puno, Peru
Authors: Melissa S Burroughs Pena, Karina Romero, Antonio Bernabe Ortiz, Eric J Velazquez, J. Jaime Miranda, Robert H Gilman, William Checkley
Journal: Circulation (2014)

Background: Household air pollution from biomass fuel use affects 3 billion people worldwide. There are few studies that examine the relationship between biomass fuel use and blood pressure. We sought to determine if daily biomass fuel use was associated with higher blood pressure and increased hypertension in Peru. Methods: We analyzed baseline information from an age- and sex-matched, population-based study in Puno, Peru. Daily biomass fuel use was self-reported. Hypertension was defined as a systolic blood pressure (SBP) ≥140 mmHg; diastolic blood pressure (DBP) ≥90 mmHg; or self-report of diagnosis and anti-hypertensive medications. We used linear and logistic multivariable regressions, adjusting for age, sex, daily cigarette use and body mass index, to examine the relationship between daily biomass fuel use with blood pressure and hypertension, respectively. Results: Data from 1004 individuals (mean age 55.3 years, 51.7% female) were included. There was evidence of an association between daily biomass fuel use and hypertension (adjusted OR = 2.1, 95%CI 1.2 to 3.5). Subjects who reported daily use of biomass fuels had 6.0 mmHg (95% CI 4.1 to 8.0) higher SBP and 4.8 mmHg (95%CI 3.5 to 6.0) higher DBP compared to those who did not use biomass fuels daily. In a secondary analysis, we used rural residence (vs. urban) as a proxy of biomass daily use and the relationship with hypertension and systolic blood pressure was similar: a higher odds of hypertension (adjusted OR = 2.1, 95%CI 1.3 to 3.6), and higher SBP (6.7mmHg, 95% CI 4.8 to 8.6) and DBP (5.5 mmHg, 95% CI 4.3 to 6.8) in rural vs. urban participants. Conclusion: Biomass fuel use is associated with increased odds of hypertension and higher blood pressure in Puno, Peru. Reducing exposure to air pollution from biomass fuel use represents a potential opportunity for cardiovascular prevention in rural communities worldwide. Longitudinal studies to evaluate the impact of reducing household air pollution are needed.