THE ORIGIN AND THE PHYSIOLOGY OF HEPARIN: THE SPECIFIC THERAPY IN THROMBOSIS
Authors: J. Erik Jorpes
Journal: Annals of Internal Medicine (1947)

Article1 September 1947THE ORIGIN AND THE PHYSIOLOGY OF HEPARIN: THE SPECIFIC THERAPY IN THROMBOSISJ. ERIK JORPES, M.D.J. ERIK JORPES, M.D.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-27-3-361 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe Chemistry of Heparin. A few years after the discovery of heparin by McLean1in 1916, while working under Howell, the latter author found that heparin gives a color reaction for uronic acids.2When the Toronto School at the Connaught Laboratories, in 1933,3had solved the problem of preparing larger quantities of heparin directly from fresh organs, I succeeded, in 1935,4in identifying heparin, as a mucopolysaccharide resembling the chondroitin sulfuric acid of the cartilage. The strongest heparin samples were found to contain about 26 per cent of a uronic acid and about 23 per cent of glucosamine, these components...Bibliography1. MCLEAN J: The thromboplastic action of cephalin, Am. Jr. Physiol., 1916, xli, 250. CrossrefGoogle Scholar2. HOWELL WH: The purification of heparin and its chemical and physiological reactions, Bull. Johns Hopkins Hosp., 1928, xlii, 199. Google Scholar3. CHARLESSCOTT AFDA: Studies on heparin, Jr. Biol. Chem., 1933, cii, 425, 437. CrossrefGoogle Scholar4. JORPES JE: On the chemistry of heparin, Biochem. Jr., 1935, xxix, 1817. CrossrefGoogle Scholar5. WOLFROMRICE MLFA: The uronic acid component of heparin, Jr. Am. Chem. Soc., 1946, xlviii, 532. CrossrefGoogle Scholar6. BERGSTRÖM S: Ueber die Wirkungsgruppe des Heparins, Naturwiss., 1935, xxiii, 706. CrossrefGoogle Scholar7. CHARGAFFBANCROFTSTANLEY-BROWN EFWM: Studies on the chemistry of blood coagulation, Jr. Biol. Chem., 1936, cxv, 149, 155. CrossrefGoogle Scholar8. KARRERUSTERICAMERINO PEB: Ueber blutgerinnungshemmende Stoffe, Helv. Chim. Acta, 1944, xxvii, 1422. CrossrefGoogle Scholar9. JORPES JE: Ueber die Wirkungsweise des Heparins, Skand. Arch. Physiol., 1938, lxxx, 202. CrossrefGoogle Scholar10. CHARGAFFOLSON EKB: The influence of protamine on the anticoagulant effect in vivo, Jr. Biol. Chem., 1938, cxxii, 153. Google Scholar11. JAQUES LB: Heparins of various mammalian species and their relative anticoagulant potency, Science, 1940, xcii, 488. CrossrefGoogle Scholar12. HAMMARSTEN E: Zur Kenntnis der biologischen Bedeutung der Nucleinsäureverbindungen, Biochem. Ztschr., 1924, cxliv, 383. Google Scholar13. JORPES JE: On heparin, its chemical nature and properties, Acta med. Scandin., 1936, lxxxviii, 427. Google Scholar14. LISON L: La signification histochimique de la métachromasie, Compt. rend. Soc. d. biol., 1935, cxviii, 821. Google Scholar15. HOLMGRENWILANDER HO: Zur Kenntnis der Chemie und Funktion der Ehrlichschen Mastzellen, Ztschr. mikr.-anat. Forsch., 1937, xlii, 242. Google Scholar16. JORPESHOLMGRENWILANDER JEHO: Ueber das Vorkommen von Heparin in den Gefässwänden und in den Augen, Ztschr. mikr.-anat. Forsch., 1937, xlii, 279. Google Scholar17. QUENSEL U: Studien über die Gewebsmastzellen, Acta path. microbiol. Scandin., 1933, Suppl. xvi, 358. Google Scholar18. ALLENJACOBSON JGLO: Hyperheparinemia: cause of hemorrhagic syndrome associated with total body exposure to ionizing irradiation, Science, 1947, cv, 388. CrossrefGoogle Scholar19. ALLEN AW: Interruption of the deep veins of the lower extremities in the prevention and treatment of thrombosis and embolism, Surg., Gynec. and Obst., 1947, lxxxiv, 519. Google Scholar20. LINK KP: The anticoagulant from spoiled sweet clover hay, Harvey Lectures, 1943-44, 162. Google Scholar21. CRAFOORDJORPES CJE: Heparin as a prophylactic against thrombosis, Jr. Am. Med. Assoc., 1941, cxvi, 2831. CrossrefGoogle Scholar22. MURRAYMACKENZIE GR: Postoperative thrombosis and embolism, Am. Jr. Surg., N. S. 1942, lvii, 414. CrossrefGoogle Scholar23. BARKERCROMERHURNWAUGH NWHEMJM: Use of dicumarol in prevention of postoperative thrombosis and embolism with special reference to dosage and safe administration, Surgery, 1945, xvii, 207. Google Scholar24. BRUZELIUS S: Dicoumarin in clinical use: Studies on its prophylactic and therapeutic value in treatment of thrombo-embolism, Acta chir. Scandin., 1945, xcii, Suppl. 100. Google Scholar25. MURRAYBEST GCH: The use of heparin in thrombosis, Ann. Surg., 1938, cviii, 163. CrossrefGoogle Scholar26. MURRAYMACKENZIE GR: The effect of heparin in portal thrombosis. Its use in mesenterial thrombosis and following splenectomy, Canad. Med. Assoc. Jr., 1939, xli, 38. Google Scholar27. BAUER G: A venographic study of thrombo-embolic problems, Acta chir. Scandin., 1940, lxxxiv, Supp. 61. Google Scholar28. BAUER G: Heparin therapy in acute deep venous thrombosis, Jr. Am. Med. Assoc., 1946, cxxxi, 196. CrossrefGoogle Scholar29. ZILLIACUS H: On the specific treatment of thrombosis and pulmonary embolism with anticoagulants, with particular reference to the postthrombotic sequelae. The results of five years' treatment of thrombosis and pulmonary embolism at a series of Swedish hospitals during the years 1940-1945, Acta med. Scandin., 1946, Suppl. 171. Google Scholar30. BAUER G: The sequelae following leg thrombosis, Acta chir. Scandin., 1942, lxxxvi, Suppl. 74. Google Scholar31. JORPES JE: Heparin in the treatment of thrombosis, Monograph, Oxford Univ. Press, 2 Ed., 1946. Google Scholar32. MURRAY G: Anticoagulants in venous thrombosis and pulmonary embolism, Surg., Gynec. and Obst., 1947, lxxxiv, 665. Google Scholar33. BARKER NW: Clinical use of dicumarol, Med. Clin. North Am., 1945, xxix, 925 and Minnesota Med., 1946, xxix, 778. Google Scholar34. ALLENHINESKVALEBARKER EVEAWFNW: The use of dicumarol as an anticoagulant: experience in 2,307 cases, Ann. Int. Med., 1947, xxvii, 371. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: The Caroline Institute Stockholm, Sweden*Presented at the Twenty-Eighth Annual Session of the American College of Physicians, Chicago, Illinois, May 1, 1947.From the Chemistry Department, Caroline Institute, Stockholm, Sweden. 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