tbuckley/cabot-search huggingface dataset:
Biosensors Improve Diagnostic Abilities for Heart, Orthopedic Care
Authors: Mike Mitka
Journal: JAMA (2006)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
CASES OF LARYNGEAL NEOPLASMS.Read in the Section on Laryngology and Otology at the Forty-fourth Annual Meeting of the American Medical Association.
Authors: ROBERT LEVY
Journal: JAMA (1893)

The following cases are reported, not with the view of adding anything new to the already extensive laryngeal literature, but for the purpose of placing on record two interesting cases: <i>Case 1</i>.—A. K., female, age 21 months, was brought to my office Aug. 22, 1892, having been referred to me by Dr. Blickensderfer of Denver. The child presented all the evidences of laryngeal dyspnea with marked stridor and especial embarrassment in inspiration. The voice was aphonie and there was a slight cough. The general condition of the child was bad; her appetite was poor; she was anemic, weak, with a rapid, small pulse. The following history was obtained: at birth the little one required resuscitating, which was accomplished in about one hour with great difficulty. After this, the voice and respiration were good until at the age of about 8 months when, with the beginning of dentition there developed some
Rituximab fixed retreatment versus on-demand retreatment in refractory rheumatoid arthritis: comparison of two B cell depleting treatment strategies
Authors: Y K O Teng, J Tekstra, F C Breedveld, F Lafeber, J W J Bijlsma, Jacob M van Laar
Journal: Annals of the Rheumatic Diseases (2009)

Rituximab, an anti-CD20 monoclonal antibody, has been approved for treatment in patients with rheumatoid arthritis (RA) who have failed treatment with tumour necrosis factor (TNF) blocking agents.1 Previous studies have demonstrated its safety, efficacy and prevention of radiographic progression;2 3 however few studies have yet addressed the timing of repeated courses of rituximab. A study in 22 patients with RA showed that treatment with repeated courses of rituximab over a 5-year follow-up period was safe and well tolerated4 and additionally an open-label extension study of 3 large randomised, double-blind studies in patients with RA showed that clinical efficacy was maintained with subsequent courses of rituximab, comparable to the first rituximab course, without increased additional safety concerns.5 Interestingly, one …
PATHOLOGIC RENAL CHANGES-Reply
Authors: J. P. Simonds
Journal: JAMA (1942)

[The letter was referred to Dr. J. P. Simonds, who replies:] <h3>To the Editor:—</h3> 1. In answering the first question in the letter of Dr. Zeisler a distinction must be made between the total osmotic pressure of the plasma and that part of the total which is effective in controlling the exchange of fluids between blood and tissues. The solutes in the plasma are responsible for the greater part of its total osmotic pressure but, because the walls of the capillaries are permeable to them, they have little or nothing to do with the exchange of fluids between blood and tissue spaces. For the latter, the osmotic pressure of the plasma proteins and the hydrostatic pressure of the blood in the capillaries are responsible. The drawing of solutes into capillary blood will obviously increase the total osmotic pressure of the plasma but will not alter the effective osmotic pressure of
Transmembrane Potential Properties at the Core of Functional Reentrant Wave Fronts in Isolated Canine Right Atria
Authors: Charles A. Athill, Takanori Ikeda, Young-Hoon Kim, Tsu-Juey Wu, Michael C. Fishbein, Hrayr S. Karagueuzian, Peng-Sheng Chen
Journal: Circulation (1998)

Background —The characteristics of transmembrane potential (TMP) at the core of functional reentry in the atrium are not well understood. Methods and Results —In protocol 1 (11 dogs), isolated perfused canine right atria were mapped from the endocardial surface while simultaneous TMPs were recorded from the epicardial surface. Episodes of reentry (n=64) were induced in the presence of 1 to 5 μmol/L acetylcholine. Successful simultaneous TMP recordings and activation maps were made in 8 episodes. The TMP was “near the core” if it was within 3.2 mm of the core; otherwise, it was considered to be “in the periphery.” The mean cycle length of reentry was 110±35 ms. The TMP amplitude, duration (90% repolarization), and (dV/dt) max near the core (n=106) were 58±22 mV, 46±14 ms, and 33±20 V/s, respectively, significantly less than those in the periphery (n=241): 70±8 mV, 94±32 ms, and 55±10 V/s ( P &lt;0.001 for all). In 2 episodes of reentry, the cell at the core remained unexcited at its resting membrane potential. In protocol 2 (2 dogs), we performed simultaneous high-density mapping in 4 episodes of reentry and showed synchronous activation patterns on both surfaces with similar locations of the core. Conclusions —During meandering functional reentry in isolated canine right atria, (1) TMPs of cells near the core have a reduced amplitude, duration, and (dV/dt) max , and (2) cells at the core may remain unexcited at their resting membrane potential. These findings are compatible with the spiral wave concept of functional reentry in the atrium.
Treating Idiopathic Intracranial Hypertension—Reply
Authors: Michael Wall, Michael P. McDermott, Karl D. Kieburtz, Mark J. Kupersmith
Journal: JAMA Neurology (2014)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Neurology HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Neurology journal
Occult Prostate Cancer in Men With Low Serum Testosterone Levels
Authors: Abraham Morgentaler
Journal: JAMA (1996)

To determine the prevalence of occult prostate cancer in men with low serum total testosterone or free testosterone levels.Retrospective analysis of a consecutive series of men.Academic teaching hospital.Seventy-seven men with low total testosterone or free testosterone levels, with normal results of digital rectal examination and prostate-specific antigen (PSA) levels of 4.0 ng/mL or less. The mean age was 58 years.Sextant prostate needle biopsies with ultrasound guidance.Results of prostate needle biopsies, transrectal ultrasound, prostate volume, PSA level, PSA density, total and free testosterone levels.Prostate cancer was identified in 14% (11/77) of the entire group and in 10 men (29%) aged 60 years or older. The median age for men with cancer was 64 years. Histologic examination showed Gleason scores of 6 or 7 for all cancers. No significant differences were noted between the cancer and benign groups with regard to PSA level, PSA density, prostate volume, total testosterone level, or free testosterone level.A high prevalence of biopsy-detectable prostate cancer was identified in men with low total or free testosterone levels despite normal PSA levels and results of digital rectal examination. These data suggest that (1) digital rectal examination and PSA levels are insensitive indicators of prostate cancer in men with low total or free testosterone levels, and (2) PSA levels may be altered by naturally occurring reductions in serum androgen levels.
Book Review The Western Medical Tradition: 1800 to 2000 By W.F. Bynum, Anne Hardy, Stephen Jacyna, Christopher Lawrence, and E.M. Tansey. 614 pp., illustrated. New York, Cambridge University Press, 2006. $90 (cloth); $29.99 (paper). 978-0-521-47524-2 (cloth); 978-0-521-47565-5 (paper).
Authors: Ronald L. Numbers
Journal: New England Journal of Medicine (2007)
A Portable System for Continuous Intravenous Insulin Delivery: Characteristics and Results in Diabetic Patients
Authors: Amir K Hanna, Howard L Mlnuk, A Michael Albisser, Errol B Marliss, Bernard S Leibel, Bernard Zinman
Journal: Diabetes Care (1980)

A portable insulin delivery system for clinical use has been developed, with the aim of improving glycemic control for prolonged periods for individuals with insulin-dependent diabetes. It weighs 1.5 kg and measures 8 × 11 × 20 cm. A plastic case contains two insulin reservoirs, two peristaltic pumps (flow variability ± 3%), a battery pack, and voltage regulator. Silastic tubes connect the reservoirs to an indwelling intravenous catheter inserted into the arm. The system is carried by a strap over the shoulder. One pump operates continuously, giving insulin at a “basal” rate, and the other is activated during meals to give a preprogrammed waveform of insulin, the latter controlled by a small bedside unit. Twelve insulin-dependent diabetic patients were infused with insulin by this system for 4–60 days (mean 18 days), for a total of 199 patient days. Insulin delivery rates were modified according to data obtained by intermittent glycemic monitoring, and on one and in some cases two days glycemia was continuously monitored (N = 10). With a basal infusion rate of 18 ± 2 mU/min (mean ± SEM), fasting glycemia was 99 ± 7 mg/dl. The mean insulin delivered with meals was 12 ± 2 U for breakfast, 9 ± 2 U for lunch, and 11 ± 2 U for dinner. Mean glycemia before lunch and supper was 102 ± 6 and 121 ± 11 mg/dl, respectively. The lowest mean glycemia occurred after lunch (88 ± 7 mg/dl) and the mean peak postprandial glycemia was 136 ± 8 mg/dl (2 h after supper). The range from lowest to highest observed value was 47–189 mg/dl. This system is capable of maintaining glycemia within the normal range for periods up to 60 days. Further refinement of the waveforms of insulin delivery may allow for total glycemic normalization. The future refinement of such a system will allow for longer-term studies addressing the relationship between glycemic control and complications.
Structure-Function Relationships in the Tissue Inhibitors of Metalloproteinases
Authors: Frances Willenbrock, Gillian Murphy
Journal: American Journal of Respiratory and Critical Care Medicine (1994)

The tissue inhibitors of metalloproteinases (TIMPs) are proteins that specifically inhibit the matrix metalloproteinases. They consist of two distinct structural and functional domains. In order to elucidate the role of these domains, we have prepared mutants of TIMP-1 and TIMP-2 that lack a C-terminal domain. The N-terminal domain alone is an efficient inhibitor of all the matrix metalloproteinases through interaction with the enzyme catalytic domain. The C-terminal domain has at least two separate enzyme binding sites, one for gelatinase A and the other for stromelysin-1. The rate of inhibition of either enzyme is increased by interaction with the TIMP C-terminal domain. As no conformational change is observed, we propose that the rate enhancement is due to an anchoring effect in which binding of the TIMP C-terminal domain aligns the TIMP N-terminal domain with the enzyme active site. Site-directed mutagenesis of TIMP-1 has demonstrated that the N-terminal amino acids, His7 and Gln9, are important for inhibition.
The kinetics of the tissue distribution of silver nanoparticles of different sizes
Authors: D.P.K. Lankveld, A.G. Oomen, P. Krystek, A. Neigh, A. Troost – de Jong, C.W. Noorlander, J.C.H. Van Eijkeren, R.E. Geertsma, W.H. De Jong
Journal: Biomaterials (2010)
(8) Comparison of psoriasis treated with cyclosporin alone or cyclosporin and clobetasol propionate
Authors: C.E.M. Griffiths, A.V. Powles, B.S. Baker, L. Fry, J. Voorhees
Journal: British Journal of Dermatology (1987)

Journal Article (8) Comparison of psoriasis treated with cyclosporin alone or cyclosporin and clobetasol propionate Get access C.E.M. Griffiths, C.E.M. Griffiths Department of Dermatology, St Mary's Hospital, London W2 U.K. Search for other works by this author on: Oxford Academic Google Scholar A.V. Powles, A.V. Powles Department of Dermatology, St Mary's Hospital, London W2 U.K. Search for other works by this author on: Oxford Academic Google Scholar B.S. Baker, B.S. Baker Department of Dermatology, St Mary's Hospital, London W2 U.K. Search for other works by this author on: Oxford Academic Google Scholar L. Fry, L. Fry Department of Dermatology, St Mary's Hospital, London W2 U.K. Search for other works by this author on: Oxford Academic Google Scholar J. Voorhees J. Voorhees The University of Michigan, U.S.A. Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 117, Issue s32, 1 June 1987, Pages 35–36, https://doi.org/10.1111/j.1365-2133.1987.tb12026.x Published: 01 June 1987
THE HYPOPITUITARY TYPE OF OBESITY TREATED WITHOUT GLANDULAR MEDICATION
Authors: JOSEPHINE HEMENWAY KENYON
Journal: JAMA (1933)

An unusual method of treating obesity was described in 1929 by Dr. Evans and Dr. Strang of Pittsburgh.<sup>1</sup>Their further reports<sup>2</sup>stimulated my interest. From December, 1931, to March, 1933, fifty overweight patients came under my supervision in private practice and were given a modification of the high protein diet. These patients were chosen because they presented the typical distribution of fat pads, commonly ascribed to hypopituitarism—girdle weight, pads on the upper arms, fat folds across the middle of the back, over the iliac crests, in the supratrochanteric regions and above the knee on the inner side of the thigh. The fat on the abdomen varied from the single or double roll of fat to the overhanging apron. There were ten patients with the very thick lower leg, of the "piano" leg type. All but six children had dieted previously but had regained their weight in the same
Impact of Metabolic Syndrome on Atrial Fibrillation Recurrence Post Cryoballoon Catheter Ablation
Authors: Firdevs Ayşenur Ekizler, Bihter Senturk, Burak Acar, Pinar Dogan, Ozcan Ozeke, Osman Turak, Firat Ozcan, Serkan Cay, Serkan Topaloglu, Dursun Aras
Journal: Journal of the American College of Cardiology (2013)
Return to Life: Two Imaginings of the Lazarus Theme
Authors: Marjorie C. Meehan
Journal: JAMA (1977)

ABSTRACT The Physician of the Dance of Death: A Historical Study of the Evolution of the Dance of Death Mythus in Art, by Aldred Scott Warthin (reprint of 1931 ed), 142 pp, 91 illus, $12, New York, Arno Press, 1977.Death and the Visual Arts, by James M. Clark (reprint of the 1950 ed of The Dance of Death in the Middle Ages and the Renaissance), 226 pp, with illus, $17, New York, Arno Press, 1977.In the past few years, death has become an increasingly popular topic of books, essays, and even television programs. Arno Press, which reprints groups of out-of-print books, has responded to this interest by issuing a collection of 40 volumes under the joint title The Literature of Death and Dying. The contents are extremely varied. They range in time of original publication from the 17th century (works of John Donne, Francis Bacon, and Thomas Browne) to
Highway Violence and Public Policy
Authors: William H. Foege
Journal: New England Journal of Medicine (1987)

A new interest in reducing the adverse health effects of violence is evident. The Surgeon General has held a workshop on violence and public health,1 the National Research Council and the Institute of Medicine have published a report on injury in America,2 and the National Highway Traffic Safety Administration has provided funds for the development of an Injury Epidemiology and Control Center at the Centers for Disease Control. State and local health departments, professional organizations, and citizen groups have become active in laws restraining children in automobiles, suicide prevention, and restrictions on driving after alcohol consumption. The epidemiology of violence . . .
THE RATE OF BACTERICIDAL ACTION OF PENICILLIN IN VITRO AS A FUNCTION OF ITS CONCENTRATION, AND ITS PARADOXICALLY REDUCED ACTIVITY AT HIGH CONCENTRATIONS AGAINST CERTAIN ORGANISMS
Authors: Harry Eagle, A. D. Musselman
Journal: The Journal of Experimental Medicine (1948)

1. The concentrations of penicillin G which (a) reduced the net rate of multiplication, (b) exerted a net bactericidal effect, and (c) killed the organisms at a maximal rate, have been defined for a total of 41 strains of α- and ß-hemolytic streptococci, Staphylococcus aureus and Staphylococcus albus, Diplococcus pneumoniae, and the Reiter treponoma. 2. The concentration which killed the organisms at a maximal rate was 2 to 20 times the minimal effective level ("sensitivity" as ordinarily defined). With some organisms, even a 32,000-fold increase beyond this maximally effective level did not further increase the rate of its bactericidal effect. However, with approximately half the strains here studied (all 4 strains of group B ß-hemolytic streptococci, 4 of 5 group C strains, 5 of 7 strains of Streptococcus fecalis, 2 of 4 other α-hemolytic streptococci, and 4 of 9 strains of staphylococci), when the concentration of penicillin was increased beyond that optimal level, the rate at which the organisms died was paradoxically reduced rather than increased, so that the maximal effect was obtained only within a relatively narrow optimal zone. 3. There were marked differences between bacterial species, and occasionally between different strains of the same species, not only with respect to the effective concentrations of penicillin, but also with respect to the maximal rate at which they could be killed by the drug in any concentration. Although there was a rough correlation between these two factors, there were many exceptions; individual strains affected only by high concentrations of penicillin might nevertheless be killed rapidly, while strains sensitive to minute concentrations might be killed only slowly. 4. Within the same bacterial suspension, individual organisms varied only to a minor degree with respect to the effective concentrations of penicillin. They varied strikingly, however, in their resistance to penicillin as measured by the times required to kill varying proportions of the cells.
Short-term effects of cardiac resynchronization on brain natriuretic peptide release in patients with systolic heart failure and ventricular conduction disturbance
Authors: Karsten Filzmaier, Anil M. Sinha, Ole A. Breithardt, Hugo Stiegler, Yurko Fischer, Jürgen Graf, Karl Mischke, Christoph Stellbrink
Journal: Journal of the American College of Cardiology (2002)
Open access endoscopy--a nationwide survey of current practice.
Authors: M G Bramble
Journal: Gut (1992)

In a postal survey of 450 members of the Endoscopy Section of the British Society of Gastroenterology carried out during 1990, 47% of respondants stated that they were offering some form of open access endoscopy. Virtually all of these were offering open access gastroscopy, but one in three were also performing open access flexible sigmoidoscopy. Those units that offered open access endoscopy had significantly more endoscopists sharing the workload, including a greater number of clinical assistants. Only 10% of those who replied, however, were offering 9true9 open access endoscopy, the remainder used some form of 9censoring9. There were also important differences in consultants9 attitudes to the investigation and management of patients referred with dyspepsia, which may account for the patchy availability of the service. Some 71% of those who did not offer open access endoscopy cited an inability to cope with numbers as their main reason for not doing so. Support for these concerns is gained from the finding that 52% of those that offered the service have had a waiting list exceeding six weeks at some time. Nevertheless, open access endoscopy is becoming more widely available with a large increase in participating units during the past 12 months.
Battered Women: Not-So-Hot Lines
Authors: Nicholas Cunningham
Journal: JAMA (1993)

<h3>To the Editor.</h3> —The June 17, 1992, announcement by president Richard F. Jones of the American College of Obstetricians and Gynecologists (ACOG) of the college's renewed commitment to address the needs of battered women<sup>1</sup>was most welcome. Concerning ACOG's intention to produce the "most up-to-date information" for patients and providers, the toll-free hot-line telephone number ([800] 333-SAFE), which ACOG wishes to make "as familiar as 911," has already been changed. When I tried to call the new number ([800] 432-9777), it had been disconnected. I tried the New York State hot line for battered women ([800] 942-6906), but the operator merely referred me to Victim Services, which (at 2 AM) was busy for at least 45 minutes before I gave up. Hot lines can only help battered women and become familiar if they are accessible and helpful. Right now they are not so hot, and what is most familiar