SIMMONDS' DISEASE WITH THERAPEUTIC RESPONSE TO HORMONE THERAPY FOR FOUR YEARS: REPORT OF A CASE WITH NECROPSY FINDINGS
Authors: Ward Darley, Robert W. Gordon, Karl T. Neubuerger
Journal: Annals of Internal Medicine (1944)

Case Reports1 November 1944SIMMONDS' DISEASE WITH THERAPEUTIC RESPONSE TO HORMONE THERAPY FOR FOUR YEARS: REPORT OF A CASE WITH NECROPSY FINDINGSWARD DARLEY, M.D., F.A.C.P., ROBERT W. GORDON, M.D., F.A.C.P., KARL T. NEUBUERGER, M.D.WARD DARLEY, M.D., F.A.C.P.Search for more papers by this author, ROBERT W. GORDON, M.D., F.A.C.P.Search for more papers by this author, KARL T. NEUBUERGER, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-21-5-890 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe recent and exhaustive review by Escamilla and Lisser1of the literature concerning hypophyseal cachexia (Simmonds' disease) is most timely. From this review it is apparent that confusion regarding the recognition of the syndrome has been very great. The facts that out of 595 reported cases only 101 were proved pathologically and that out of the remaining 494 cases only 158 were typical clinically bear out this contention. As a result of Escamilla's and Lisser's careful analysis of the proved cases, their definition of clinical criteria should lessen the confusion in the recognition of the condition and should serve as...Bibliography1. ESCAMILLALISSER RFH: Simmonds' disease. A clinical study with review of the literature; differentiation of anorexia nervosa by statistical analysis of 595 cases, 101 of which were proved pathologically, Jr. Clin. Endocrin., 1942, ii, 65-96. CrossrefGoogle Scholar2. BERBLINGER W: Die hypophysaere Kachexie (Simmonds'sche Krankheit), Handbuch der inneren Sekretion (M. Hirsch), 1932, C. Kabitzsch, Leipzig, vol. i, pp. 958-980. Google Scholar3. MEERWEIN F: Ueber die multiple Blutdruesensklerose Falta, Frankfurt. Ztschr. f. Path., 1938, lii, 54-79. Google Scholar4. CASTLEMANHERTZ BS: Pituitary fibrosis with myxedema, Arch. Path., 1939, xxvii, 69-79. Google Scholar5. HIRSCHBERBERICH SJ: Ein Beitrag zur Frage der multiplen Blutdruesensklerose, Klin. Wchnschr., 1924, iii, 483-486. CrossrefGoogle Scholar6. JAFFÉ R: Luetische Erkrankungen der Hypophyse, Frankfurt. Ztschr. f. Path., 1922, xxvii, 324-335. Google Scholar7. GALLAVANSTEEGMANN MAT: Simmonds' disease (anterior hypophyseal insufficiency): report of two cases with autopsy, Arch. Int. Med., 1937, lix, 865-882. CrossrefGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Denver, Colorado*Received for publication March 11, 1943.From the Departments of Medicine and Pathology, University of Colorado School of Medicine and Hospitals. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byNeonatal hypoglycemia caused by hypopituitarism in infants with congenital syphilisDas Zentralnervensystem bei Krankheiten der Drüsen mit innerer SekretionDie Keimdrüsen und ihre KrankheitenSimmonds' diseaseAnterior pituitary and pancreas 1 November 1944Volume 21, Issue 5Page: 890-902KeywordsHormonal therapyHormonesHospital medicine Issue Published: 1 November 1944 PDF downloadLoading ...