tbuckley/cabot-search huggingface dataset:
FAR EAST COMMAND CONFERENCE ON EPIDEMIC HEMORRHAGIC FEVER: INTRODUCTION
Authors: Joseph H. Mcninch
Journal: Annals of Internal Medicine (1953)

Article1 January 1953FAR EAST COMMAND CONFERENCE ON EPIDEMIC HEMORRHAGIC FEVER: INTRODUCTIONJOSEPH H. MCNINCHJOSEPH H. MCNINCHSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-38-1-53 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptToday we have before us for discussion a disease entity which has created intense interest among both medical and lay personnel in the Far East Command. During the month of June, 1951, there were admitted to the United States medical installations in Korea several patients with an acute febrile disease presenting a combination of symptoms and signs not previously encountered among United Nations personnel in Korea. The symptoms included malaise, weakness, chills, fever, headache (especially retrobulbar ache), blurred vision, nausea and vomiting. These symptoms were associated with manifestations of hemorrhagic diathesis: petechial rash, marked injection of the conjunctivae, hematuria and... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: MC Far East Command*Received for publication July 25, 1952.The Far East Command Conference on Epidemic Hemorrhagic Fever was held in Korea in December 1951. From the numerous papers presented to this Conference and submitted to the ANNALS OF INTERNAL MEDICINE for publication, a selection was made by the Board of Editors of those which would give to the readers of this Journal a general picture of this interesting disease.—EDITOR. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byLessons Learned From the U.S. Military Experience With Hantavirus During the Korean WarHANTAVIRUSESHereditäre und endemische Nephropathien vorwiegend interstitieller LokalisationArbor-Viren (durch Arthropoden übertragbare Viren)Das epidemische h�morrhagische FieberA CASE OF EPIDEMIC HEMORRHAGIC FEVER IN THE UNITED STATES*BLAINE Z. HIBBARD, M.D., V. BRYCE BALLARD, M.D., DAVID M. GIBSON, M.D.I. Epidemic haemorrhagic fever 1 January 1953Volume 38, Issue 1Page: 53-60KeywordsFeversHeadachesHemorrhagic feversNauseaPainRashesSigns and symptomsVisionVomiting ePublished: 1 December 2008 Issue Published: 1 January 1953 PDF downloadLoading ...
Abstract 48: Identification of a novel binding protein playing a critical role in HER2 activation in lung cancer cells
Authors: Tomoaki Ohtsuka, Masakiyo Sakaguchi, Katsuyoshi Takata, Shinsuke Hashida, Mototsugu Watanabe, Ken Suzawa, Yuho Maki, Hiromasa Yamamoto, Junichi Soh, Hiroaki Asano, Kazunori Tsukuda, Shinichiro Miyoshi, Shinichi Toyooka
Journal: Cancer Research (2015)

Abstract Human epidermal growth factor receptor 2 (HER2) is a member of epidermal growth factor receptor (EGFR) family. Previous studies have revealed that many kinds of malignant tumors have genetic mutations or amplification of HER2, indicating that HER2 alterations are oncogenic. Many kinds of HER2 targeted therapies are effective to HER2 positive tumors, but those treated tumors often get resistance to drugs. Thus, to elucidate HER2 related pathway in cancer biology is important to develop new therapeutic strategy for cancers. Recently, we newly identified a protein X (a temporary name) as a novel binding protein to HER2 with immunoprecipitation and following LC-Ms/Ms analysis. The protein generally expressed in lung and breast cancers at remarkable level. We constructed plasmid vectors carrying wild type HER2 and gene X. These vectors were simultaneously introduced to HEK293T cells to examine the binding ability of protein X and HER2 as well as the effect of gene X on HER2-mediated signal-transduction pathway. The approach clearly showed that the expression of gene X, resulted in phosphorylation of HER2 and subsequent activation of oncogenic effector molecules. We next constructed several kinds of gene X-truncated variants and subjected to the binding assay to look for the binding domain of gene X to HER2. The analysis showed that N-terminal head domain of gene X was essential for the HER2 binding. This domain has an ability to induce HER2 phosphorylation and subsequent activation of the effector kinase, ERK. In conclusion, we found that gene X is a novel binding protein to HER2 and has a role in HER2 activation. Citation Format: Tomoaki Ohtsuka, Masakiyo Sakaguchi, Katsuyoshi Takata, Shinsuke Hashida, Mototsugu Watanabe, Ken Suzawa, Yuho Maki, Hiromasa Yamamoto, Junichi Soh, Hiroaki Asano, Kazunori Tsukuda, Shinichiro Miyoshi, Shinichi Toyooka. Identification of a novel binding protein playing a critical role in HER2 activation in lung cancer cells. [abstract]. In: Proceedings of the 106th Annual Meeting of the American Association for Cancer Research; 2015 Apr 18-22; Philadelphia, PA. Philadelphia (PA): AACR; Cancer Res 2015;75(15 Suppl):Abstract nr 48. doi:10.1158/1538-7445.AM2015-48
Abstract 18799: Correlation of 2D Strain for Intraoperative Assessment of Right Ventricular Mechanics with Admittance Catheters in Juvenile Pigs
Authors: Sandhya R Ramlogan, Richard A Hopkins, Stephen F Kaine, Eric Buse, Suma P Goudar, Hongying Dai, Girish S Shirali
Journal: Circulation (2014)

Background: Surgical manipulations such as opening the chest and volume loading have the potential to alter ventricular function. There is paucity of data on the effects of such manipulations on right ventricular (RV) function. We measured tricuspid annular plane excursion (TAPSE) and RV strain by two-dimensional echo (2DE) speckle tracking to assess systolic and diastolic RV function in juvenile pigs under conditions that simulate the intraoperative environment. These were compared to simultaneously obtained parameters of RV function using admittance catheters. Methods: Epicardial 2DE was performed (Philips iE33) in 6 juvenile pigs (19-23kg). TAPSE and systolic and diastolic 2D RV longitudinal strain (LS) and strain rate (LSR) (TomTec Image Arena, TomTec, Germany) were measured offline. RV systolic and diastolic pressure/volume data was acquired simultaneously using admittance catheters (Scisense Inc, Canada) under conditions including closed chest, open chest and volume loading. Comparisons were made us...
Outbreaks of Gastroenteritis Associated With Noroviruses on Cruise Ships—United States, 2002
Authors: E. H. Cramer, D. Forney, A. L. Dannenberg, M. A. Widdowson, J. S. Bresee, S. Monroe, R. S. Beard, H. White, S. Bulens, E. Mintz, C. Stover, E. Isakbaeva, J. Mullins, J. Wright, V. Hsu, W. Chege, J. Varma
Journal: JAMA (2003)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Abstract P083: Is Change In Ectopic Fat Following A Weight Loss Intervention Associated With Change In Vascular Stiffness In Young Men And Women?
Authors: Carrie Hanley, Bethany Barone Gibbs, Emma Barinas-Mitchell, Jennifer Cooper, Giang Le, Bret H Goodpaster, Molly B Conroy
Journal: Circulation (2014)

Background: Ectopic fat may be a better indicator of CVD risk than conventional measures of obesity such as BMI. Data are lacking in how changes in ectopic fat relate to changes in arterial stiffness, and whether there are differences by sex. Our objectives were to determine: (1) how ectopic fat changes after a behavioral weight loss intervention and whether changes differ by sex; and (2) if the changes in ectopic fat are associated with changes in arterial stiffness independently of BMI change. Methods: Longitudinal analyses were conducted on 203 participants with complete ectopic fat and vascular stiffness data in the Slow Adverse Vascular Effects study, a randomized trial of a behavioral weight loss intervention in 349 men and women aged 20-45 years and BMI 25-40 kg/m 2 . CT scans measured total abdominal adipose tissue (TAAT), visceral AT (VAT), total thigh AT (TTAT), and intramuscular thigh AT(IMAT). Carotid-femoral (cf) and brachial-ankle (ba) pulse-wave velocity (PWV) were measures of central and mixed central/peripheral arterial stiffness, respectively. T-tests evaluated how ectopic fat and PWV measures differed between men and women at and between baseline and 12-months. Sex-stratified linear regression analyses evaluated associations between changes in regional adiposity and arterial stiffness from baseline to 12 months. Results: Mean age of participants at baseline was 38.2 ± 5.9 years; mean BMI was 32.2 ± 3.9 kg/m 2 ; 150 (73.9%) were women; and 166 (81.8%) were white. Men were significantly (all p&lt;0.05) different from women at baseline with more VAT (159.1 vs. 100.0 cm 2 ), less TTAT (96.1 vs. 147.8 cm 2 ), higher BMI (33.5 vs. 31.8 kg/m 2 ), higher baPWV (1257.3 vs. 1193.5 cm/s), and higher cfPWV (968.6 vs. 850.9 cm/s). At 12 months, men lost significantly more VAT (-29.2 vs. -13.7 cm 2 ) and had a greater decrease in cfPWV (-103.2 vs. -24.7 cm/s) compared to women (both p&lt;0.05). After adjusting for age, baseline PWV, and change in SBP, decreases in TAAT and TTAT were significantly associated with improved vascular stiffness as measured by baPWV among men, and a decrease in VAT was significantly associated with improved cfPWV among women (all p&lt;0.05). These relationships lost significance after adjusting for change in BMI. Change in BMI was itself not a significant predictor for the change in the arterial stiffness measures in either men or women in final models. Conclusions: We found several novel associations between changes in ectopic fat and PWV in young adults in a weight loss intervention; these associations differed by sex and dissipated after controlling for change in BMI. Change in BMI itself was not a significant predictor of change in either arterial stiffness measure in men or women. Further research with a larger sample and more diverse population may be warranted to better understand these associations.
NOISE-INDUCED HEARING LOSS
Authors: Nuzhat Huma Akhtar
Journal: JAMA (1966)

Excessive sound is one of the most common cause of hearing loss. The hazardous effects of noise on hearing have been studied for over a century. Over the past few decades, considerable attention has been given to the mechanisms and features of noise induced hearing loss. the sound levels in urban communities are apparently rising and the nuisance valve of unwanted sound is greatly increased. The most serious pathological effect of noise on man is hearing loss leading to complete deafness. The victim is generally unaware of it in the early stages. Repeated and continuous exposure to noise above 90 dB(A) may result in permanent hearing loss.
Association of Cortical Lesion Burden on 7-T Magnetic Resonance Imaging With Cognition and Disability in Multiple Sclerosis
Authors: Daniel M. Harrison, Snehashis Roy, Jiwon Oh, Izlem Izbudak, Dzung Pham, Susan Courtney, Brian Caffo, Craig K. Jones, Peter van Zijl, Peter A. Calabresi
Journal: JAMA Neurology (2015)

Cortical lesions (CLs) contribute to physical and cognitive disability in multiple sclerosis (MS). Accurate methods for visualization of CLs are necessary for future clinical studies and therapeutic trials in MS.
Abstract 3807: A novel imidazole derivate inhibits STAT3 activation via induction of SHP-1 hepatocellular carcinoma
Authors: Jung-Chen Su, Szu-Hsien Wu, Kuen-Feng Chen, Wei-Tien Tai, Jui-Wen Huang, Chung-Wai Shiau
Journal: Cancer Research (2014)

Abstract The activation of STAT3 signaling cascade has been linked with cell survival, proliferation, and angiogenesis in HCC. Literature have shown that overexpression of SHP-1 suppressed cell proliferation in varies cancer cells. Compounds that can activate SHP-1 and further repress STAT3 activity pathway have potential for treatment of HCC. We investigated whether imidazole derivates can modulate the SHP-1/STAT3 pathway. The result showed that imidazole derivate inhibited both constitutive and interleukin 6-inducible STAT3 phosphorylation in HCC cells and induced cell apoptosis. In addition, we explored protein tyrosine phosphatases (SHP-1 and SHP-2) expression level in HCC cells with the treatment of the imidazole derivate. Interestingly, the imidazole derivate significantly induced the expression of SHP1 and subsequently inhibited the phosphorylation of Src , Jak2 and STAT3. This agent also repressed the expression of STAT3-regulated target genes, including cyclin D1, Mcl-1, and survivin. Overall, our results suggest that the imidazole derivate blocks STAT3 activation through up-regulation of SHP-1, and this may have potential for combination with other chemotherapeutic agents. Citation Format: Jung-Chen Su, Szu-Hsien Wu, Kuen-Feng Chen, Wei-Tien Tai, Jui-Wen Huang, Chung-Wai Shiau. A novel imidazole derivate inhibits STAT3 activation via induction of SHP-1 hepatocellular carcinoma. [abstract]. In: Proceedings of the 105th Annual Meeting of the American Association for Cancer Research; 2014 Apr 5-9; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2014;74(19 Suppl):Abstract nr 3807. doi:10.1158/1538-7445.AM2014-3807
A streamlined, aptamer-based multiplex proteomic assay for diagnostic applications
Authors: Chris Bock, Evaldas Katilius, Tracy Keeney, Stephan Kraemer, Nick Saccomano, Glenn Sanders, Jonathan Vaught, Dom Zichi
Journal: Clinical Cancer Research (2010)

Abstract To enable the application of protein signatures identified in our highly multiplexed biomarker discovery platform to real-world diagnostics, we developed a streamlined, plate-based assay that employs the same principles as the larger SOMAScan assay. The plate-based assay is sensitive (sub-picomolar), robust, rapid, automatable, and can multiplex upwards of 60 analytes. We have used this platform to seamlessly translate sets of biomarkers identified in our SOMAScan assay to a practical non-small cell lung cancer diagnostic.
Effects of dopamine blockade on gonadotropins and testosterone in men
Authors: Siris Sg, Siris Es, van Kammen Dp, Docherty Jp, Alexander Pe, Bunney We
Journal: American Journal of Psychiatry (1980)

The authors found that plasma luteinizing hormone (LH), prolactin, and testosterone were initially normal in nine acutely psychotic males with schizophrenia or schizo-affective disorder; follicle-stimulating hormone (FSH) was normal in eight of the nine. When patients were treated with pimozide, a relatively specific dopamine receptor blocker, there were statistically significant declines in FSH and LH, although levels remained within normal limits. Prolactin rose significantly, but testosterone did not change. The observed reductions in FSH and LH concentrations are consistent with the hypotheses that dopamine and/or prolactin play a role in gonadotropin secretion. The maintenance of normal levels of gonadotropins and testosterone, however, suggests that these patients possessed relatively normal hypothalamic-pituitary-gonadal axis function before and during a course of neuroleptic treatment.
Abstract 4203: A transducer module consisting of Toll-like receptor 9 and Bruton's tyrosine kinase triggers acute myeloid leukemia blast proliferation
Authors: Thomas Oellerich, Sebastian Mohr, Hanibal Bohnenberger, Anjali Dubey, Silvia Münch, Johannes Wicht, Mark F. Oellerich, Christina Perske, Gesine Bug, Philipp Ströbel, Henning Urlaub, Hubert Serve
Journal: Cancer Research (2014)

Abstract Acute myeloid leukemia (AML) is a genetically heterogeneous disease and mutations occur in various genes including those encoding for signaling molecules. A well characterized example is the tyrosine kinase Flt3, which harbours internal tandem duplications in about one third of AML patients that render the kinase constitutively active. AML cells often become addicted to such constitutively activated survival inducing signaling pathways that can be therapeutically exploited by using small molecule kinase inhibitors. By screening bone marrow biopsies of AML patients for kinase expression profiles, we detected Bruton's tyrosine kinase (Btk) in AML blasts in 26 out of 30 analyzed cases. Btk acts as an oncogene in chronic lymphocytic leukemia as well as in certain B-cell lymphoma subtypes. As compared to diseases of lymphoid origin far less is known about the role of Btk in myeloid neoplasias. Here, we show that Btk is often constitutively activated in AML and moreover, that genetic as well as pharmacological inhibition of Btk in AML cell lines as well as primary patient-derived AML cultures strongly diminishes AML cell growth. By applying quantitative mass spectrometry, we identified a signalosome consisting of Btk and Toll-like receptor 9 that is needed to constitutively transduce proliferation signals through the NFkB pathway. This newly identified TLR9/Btk signaling axis is of clinical interest as it is effectively druggable by Btk inhibitors which have so far only indications for the treatment of lymphoid malignancies. Citation Format: Thomas Oellerich, Sebastian Mohr, Hanibal Bohnenberger, Anjali Dubey, Silvia Münch, Johannes Wicht, Mark F. Oellerich, Christina Perske, Gesine Bug, Philipp Ströbel, Henning Urlaub, Hubert Serve. A transducer module consisting of Toll-like receptor 9 and Bruton's tyrosine kinase triggers acute myeloid leukemia blast proliferation. [abstract]. In: Proceedings of the 105th Annual Meeting of the American Association for Cancer Research; 2014 Apr 5-9; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2014;74(19 Suppl):Abstract nr 4203. doi:10.1158/1538-7445.AM2014-4203
Winding the clock back on female androgenetic alopecia
Authors: R. Sinclair
Journal: British Journal of Dermatology (2012)

Journal Article Winding the clock back on female androgenetic alopecia Get access R. Sinclair R. Sinclair Epworth Hospital, University of Melbourne, Melbourne, Vic., and St Vincent’s Hospital, Melbourne, 21 Victoria Parade, Fitzroy, Melbourne 3065, Vic., Australia Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 166, Issue 6, 1 June 2012, Pages 1157–1158, https://doi.org/10.1111/j.1365-2133.2012.10934.x Published: 01 June 2012
A New Dictionary of Quotations on Historical Principles from Ancient and Modern Sources
Authors: H. L. Mencken
Journal: JAMA (1942)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Secondhand Smoke Effects
Authors: Tracy Hampton
Journal: JAMA (2005)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Interventions for Treatment of Depression in Primary Care
Authors: James C Coyne
Journal: JAMA (2004)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Myocardial Ischemia Induced by Rapid Atrial Pacing Causes Troponin T Release Detectable by a Highly Sensitive Assay
Authors: Aslan T. Turer, Tayo A. Addo, Justin L. Martin, Marc S. Sabatine, Gregory D. Lewis, Robert E. Gerszten, Ellen C. Keeley, Joaquin E. Cigarroa, Richard A. Lange, L. David Hillis, James A. de Lemos
Journal: Journal of the American College of Cardiology (2011)