IDIOPATHIC ACQUIRED HEMOLYTIC ANEMIA TREATED BY ACTH AND CORTISONE
Authors: H I CRARY, I A BECK
Journal: Annals of Internal Medicine (1952)

Case Reports1 April 1952IDIOPATHIC ACQUIRED HEMOLYTIC ANEMIA TREATED BY ACTH AND CORTISONEHORACE I. CRARY, IRVING A. BECKHORACE I. CRARYSearch for more papers by this author, IRVING A. BECKSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-36-4-1106 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptAcquired hemolytic anemia is a rare and chronic disease often accompanied by severe hemolytic crises. The red cell injury appears directly related to erythrocyte bound antibodies1which may be detected by the Coombs' test.2Numerous investigations have indicated that antibodies are produced by lymphocytes3and possibly by the reticuloendothelial system.4Attempts to destroy lymphoid tissue, and therefore the source of these injurious antibodies, by x-ray, nitrogen mustard and urethane, or to inhibit the reticuloendothelial system by Congo red saturation, have been of limited value.5Splenectomy, which removes the largest lymphoid and reticuloendothelial organ in the body, has been of benefit...Bibliography1. EvansDuane RSRT: Acquired hemolytic anemia. I. The relation of erythrocyte antibody production to activity of the disease. II. The significance of thrombocytopenia and leukopenia, Blood 4: 1196, 1949. CrossrefMedlineGoogle Scholar2. BoormanDoodLoutit KEBEJF: Haemolytic icterus (acholuric jaundice) congenital and acquired, Lancet 250: 812, 1946. CrossrefGoogle Scholar3. HarrisGrimmMertinsChurch TNEEWE: The role of the lymphocyte in antibody formation, J. Exper. Med. 81: 73, 1945. CrossrefMedlineGoogle Scholar4. Sabin FR: Cellular reactions to dye-protein with concept of mechanism of antibody formation, J. Exper. Med. 70: 67, 1939. CrossrefMedlineGoogle Scholar5. DameshekRosenthalSchwartz WMCLI: The treatment of acquired hemolytic anemia with ACTH, New England J. Med. 244: 117, 1951. CrossrefGoogle Scholar6. PearsonElielRawsonDobrinerRhoades OHLPRWKCP: ACTH and cortisone induced regression of lymphoid tumors in man, Cancer 2: 943, 1949. CrossrefMedlineGoogle Scholar7. BordleyCareyHarveyHowardKattusNewmanWinkenwerder JERAAMJEAAEVWL: Preliminary observations on the effect of adrenocorticotropic hormone (ACTH) in allergic diseases, Bull. Johns Hopkins Hosp. 85: 396, 1949. MedlineGoogle Scholar8. Gardner FH: ACTH in leukemia—report of 3 cases, Blood 5: 791, 1950. Google Scholar9. LeyGardner ABFH: The effect of cortisone acetate on idiopathic acquired hemolytic anemia, 43rd Annual Meeting of Am. Soc. for Clin. Invest., April 30, 1951. Google Scholar10. YoungChristianIzzo LERMMJ: Some newer concepts of "congenital" and "acquired" hemolytic anemias, M. Clin. North America 35: 571, 1951. CrossrefMedlineGoogle Scholar11. GardnerMcElfreshHarrisDiamond FHAEJWLK: The effect of adrenocorticotropic hormone (ACTH) in idiopathic acquired hemolytic anemia as related to the hemolytic mechanisms, J. Lab. and Clin. Med. 37: 444, 1951. MedlineGoogle Scholar12. Evans RS: Chronic hemolytic anemia, Arch. Int. Med. 77: 544, 1946. CrossrefGoogle Scholar13. Mollison PL: The survival of transfused erythrocytes with special reference to cases of acquired hemolytic anemia, Clin. Sc. 6: 137, 1947. MedlineGoogle Scholar14. StatsRosenthalWasserman DNLR: Hemolytic anemia associated with malignant diseases, Am. J. Clin. Path. 17: 585, 1947. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Providence, Rhode Island*Received for publication June 20, 1951.From the private Medical Service of the Rhode Island Hospital. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited bySerologie und Klinik der autoimmunhämolytischen ErkrankungenFour Cases of Acute Acquired Haemolytic Anaemia in Childhood Treated with A.C.T.H 1 April 1952Volume 36, Issue 4Page: 1106-1111KeywordsAdrenocorticotropic hormoneAntibodiesHemoglobinHemolytic anemiaPneumoniaResearch laboratoriesReticulocytesSplenectomySplenomegalyStreptomycin ePublished: 1 December 2008 Issue Published: 1 April 1952 PDF downloadLoading ...