tbuckley/cabot-search huggingface dataset:
ULTRASTRUCTURE OF HUMAN EPIDERMIS FOLLOWING CHRONIC SUN EXPOSURE
Authors: MARK ALLEN EVERETT, JOHN NORDQUIST, ROBERT L. OLSON
Journal: British Journal of Dermatology (1971)

Journal Article ULTRASTRUCTURE OF HUMAN EPIDERMIS FOLLOWING CHRONIC SUN EXPOSURE Get access MARK ALLEN EVERETT, MARK ALLEN EVERETT Department of Dermatology, University of Oklahoma Medical Centre, Oklahoma City, Oklahoma, U.S.A Search for other works by this author on: Oxford Academic Google Scholar JOHN NORDQUIST, JOHN NORDQUIST Department of Dermatology, University of Oklahoma Medical Centre, Oklahoma City, Oklahoma, U.S.A Search for other works by this author on: Oxford Academic Google Scholar ROBERT L. OLSON ROBERT L. OLSON Department of Dermatology, University of Oklahoma Medical Centre, Oklahoma City, Oklahoma, U.S.A Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 84, Issue 3, 1 March 1971, Pages 248–257, https://doi.org/10.1111/j.1365-2133.1971.tb14215.x Published: 01 March 1971 Article history Accepted: 26 August 1970 Published: 01 March 1971
Tetanus after allogeneic bone-marrow transplantation.
Authors: J R Kendra, O Halil, A J Barrett, S Selwyn
Journal: BMJ (1982)

units) was chosen so that any benefit could be clearly demonstrated.Most patients had been on much higher doses previously.It is inter- esting that the significant reduction in steatorrhoea caused only a small and insignificant decrease in faecal wet weight and stool frequency which may reflect the low dosage used.The use of positioned-release capsules (whatever their mode of action may be) to deliver enzyme supplements resulted, however, in a significant reduction in steatorrhoea.
Macrocytic anemia and thrombocytosis associated with thymoma: A case report
Authors: Elke Grumbeck, Paul Aiginger, Bettina Gisslinger, Klaus Geissler, Renate Thalhammer-Scherrer, Heinz Gisslinger
Journal: American Journal of Hematology (2000)

Thymomas are often associated with autoimmune disorders. We report on a 45-year-old female patient with thymoma and hypogammaglobulinemia (Good's syndrome) who developed symptomatic macrocytic anemia (Hb 4.4 g/dl, MCV 112 fl) and thrombocytosis (Plt 442 G/l). Besides hypogammaglobulinemia (IgG 589 mg/dl), an inverted ratio of CD4+/CD8+ cells was seen. The bone marrow biopsy showed a slightly hypercellular bone marrow with normal granulopoiesis, normal megakaryopoiesis and a mild dyserythropoiesis without any ring-sideroblasts. The in-vitro stem cell culture from the bone marrow revealed an atypical growth of macroclusters, reduced BFU-E and CFU-GEMM colony growth, whereas the CFU-GM colony growth was within the normal range. The chromosomal analysis showed a normal karyotype. The plasma vitamin B12 and folate levels were within normal ranges, and we could not detect any autoantibodies. These findings excluded the differential diagnoses pure red cell aplasia (PRCA) and pernicious anemia. After resection of the thymoma of mixed cell type, the macrocytic anemia and thrombocytosis disappeared. The clinical course was complicated by a cerebral palsy and a life-threatening fungal septicemia after surgery. In the third year after thymectomy, hyporegenerative macrocytic anemia and thrombocytosis reappeared and an immunosuppressive treatment with prednisolone (1 mg/kg BW) was started. After initiation of the prednisolone therapy, reticulocyte counts increased and macrocytic anemia as well as thrombocytosis disappeared. The normalization of these laboratory parameters during glucocorticoid therapy suggests that in rare cases the constellation of macrocytic anemia, thrombocytosis and hypogammaglobulinemia may be due to an underlying immunologic mechanism. Am. J. Hematol. 63:38–41, 2000. © 2000 Wiley-Liss, Inc.
Cellular Immune Responses to Extracellular Streptococcal Products in Rheumatic Heart Disease
Authors: Ernest D. Gray, Lewis W. Wannamaker, Elia M. Ayoub, Aziz El Kholy, Zahira H. Abdin
Journal: Journal of Clinical Investigation (1981)

The lymphocyte transformation responses to purified preparations of two extracellular products of group A streptococci (blastogen A and nuclease B), to phytohemagglutinin, and to Candida albicans antigen were measured in tonsillar and peripheral blood lymphocytes from patients with rheumatic heart disease (RHD) and suitably matched nonrheumatic (control) subjects.
Daily injections of the glutathione disulfide mimetic NOV-002 ameliorates hematologic toxicities from neoadjuvant chemotherapy in breast cancer patients enrolled in the NEO-NOVO trial, and significantly increases circulating dendritic cells.
Authors: C Diaz-Montero, N Paphitis, G Onicescu, Y Zhu, N Verma, E Garrett-Mayer, KC Schuhwerk, CJ Pazoles, S Glück, AJ Montero
Journal: Cancer Research (2009)

Abstract Abstract #2141 Background: Chemotherapy induced anemia is a common problem in breast cancer. Anemic events [Hgb&amp;lt;10 g/dL, use of erythropoietin stimulating agents (ESAs), or transfusion] are likely to occur in 30-40% of breast cancer patients (pts) receiving doxorubicin-cyclophosphamide (AC) and docetaxel (T). Owing to the increased risk of cancer mortality, tumor progression, and thrombovascular events associated with ESAs, other alternatives are needed. Febrile neutropenia with AC-T is a dose-limiting event and occurs in 10-20% of pts without prophylactic G-CSF. NOV-002 has been previously shown to stimulate hematopoiesis and reduce chemotherapy related hematologic toxicities, as well as have immunomodulatory properties. Methods: To determine the effect of daily NOV-002 on hematopoiesis and chemotherapy induced hematologic toxicities, weekly blood counts were obtained on all pts enrolled in the NEO-NOVO trial (Montero, et. al. SABCS 2008). Pts do not receive prophylactic G-CSF in the absence of prior febrile neutropenia with chemotherapy. To determine if NOV-002 is associated with induction of circulating dendritic cells (DCs), flow cytometry analysis is performed on whole peripheral blood prior to therapy and on day 1 of each cycle. DCs are defined as: lineage-/HLA-DR+; CD11b+/CD11c+. P-values were obtained from the signed rank test. Results: Thus far, 102 chemotherapy cycles have been administered to 16 pts. Baseline (BL) hemoglobin (Hgb), absolute neutrophil counts (ANC), and DCs are listed below.&amp;#x2028; &amp;#x2028; No grade 3-4 anemia has been observed. ESAs have been used in 2 pts (12.5%), and no blood transfusions were required. One pt (6.25%) had febrile neutropenia (0.9% of all cycles). Grade 3 neutropenia on day 1 of cycles 1-8 occurred in 2 pts (12.5%) or 1.9% of all cycles. One pt had dose delay by 1 week due to neutropenia. Cycle 5 day 1 (C5D1) DCs were significantly higher relative to BL with a trend towards being higher at C8D1. Moreover, median ANCs were significantly higher on C8D1, while median Hgb remained stable between C5D1 and C8D1. Conclusions: Anemic events and febrile neutropenia were much lower than expected with the addition of NOV-002 to AC→T, likely due to its hematopoietic properties. DC induction may be an important anti-tumor mechanism of action of NOV-002. Citation Information: Cancer Res 2009;69(2 Suppl):Abstract nr 2141.
Antipsychotic effect of buprenorphine in schizophrenia
Authors: C Schmauss, A Yassouridis, H M Emrich
Journal: American Journal of Psychiatry (1987)

The antipsychotic potency of the partial opiate agonist buprenorphine was evaluated in 10 neuroleptic-free schizophrenic patients suffering from frequent hallucinations, delusions, and severe formal thought disorders. Buprenorphine had a pronounced antipsychotic effect, which lasted about 4 hours, in patients with schizophreniform disorders (N = 4) and paranoid schizophrenia (N = 3).
The SARS epidemic in Hong Kong: what lessons have we learned?
Authors: L. S. Hung
Journal: Journal of the Royal Society of Medicine (2003)

Severe acute respiratory syndrome (SARS) reached Hong Kong in March 2003.1 From 11 March up to 6 June, a total of 1750 cases had been identified (Figure 1), and during the same period 286 people died of the disease. Before the advent of SARS in Hong Kong, the nearby Guangdong Province in Mainland China had experienced an intense outbreak of the atypical pneumonia later termed SARS. This outbreak started in November 2002 and reached its peak in February 2003; up to 5 June 2003, Guangdong had recorded 1511 cases and 57 deaths. Later in April 2003, SARS cases were reported in other provinces and cities of Mainland China including Beijing, Shanxi, Neimonggol, Tianjin and Hebei. Up to 5 June 2003, Mainland China had a total of 5329 cases with 336 reported deaths.2



Figure 1

Severe acute respiratory syndrome cases, Hong Kong, March-June 2003



From March onwards, SARS was detected in other countries and areas in the Asia-Pacific region. By the beginning of June, Singapore had had 205 cases with 28 deaths, Vietnam 63 cases with 5 deaths and Taiwan 686 cases with 81 deaths.
Treatment of Thyrotoxic Heart by Methyl Thiouracil
Authors: W. E. Clarke
Journal: BMJ (1948)

PHLEBOTHROMBOSIS AND PULMONARY EMBOLISM BRITIS special facilities, special instruments, and special skill.Femoral thrombectomy requires none of these things.The indications for femoral thrombectomy are: (1) when pulmonary embolism has occurred and mercifully the patient is yet in a fit condition to withstand operation, and (2) when phlebothrombosis decubiti has been diagnosed with some precision.To endeavour to stimulate surgeons, house-surgeons, and practitioners to undertake a careful clinical examination for phlebothrombosis in relevant cases is my main object in writing this paper.
Demonstration of Post-traumatic Bile Leak Using Technetium-99m DISIDA
Authors: I SAVITCH, J D ESSER, E SPRINGOLO, M C KEW
Journal: Clinical Nuclear Medicine (1986)

A 25-year-old miner was admitted with an acute abdomen and marked pallor following a crush injury to the abdomen. CT showed an irregular, patchy appearance of the posterosuperior portion of the liver with a coefficient of density appreciably less than the rest of the liver, consistent with the presence of a hepatic hematoma. The patient was treated conservatively. During the two weeks that followed, fluid accumulated in the peritoneal cavity. At laparotomy, a large volume of bileand blood-stained fluid was found in the peritoneal cavity. Tc-99m DISIDA imaging was done after laparotomy.
Current Diagnosis 8
Authors: William R. Best
Journal: JAMA (1992)

It has been 25 years since the first edition of this work, and the fact that it thrives indicates that it has been useful to many practitioners. Its objective has not changed: "to bring together in concise, definitive articles the best current information on medical diagnosis to assist the physician in arriving at the correct diagnosis as efficiently as possible." A section addressing 29 common diagnostic problems is followed by 16 sections on categories of disease and a final section that tabulates laboratory values of clinical importance. There are about 300 chapters, most three to seven pages in length, each written by one to four expert practitioners. Most chapters are by newly recruited authors. Formerly popular diagnostic methods that have been superseded and pitfalls of diagnosis are mentioned where appropriate. Diagnostic imaging has become increasingly important. Some topics of new or increased emphasis are the acquired immunodeficiency syndrome, toxic shock
Massive Lipoid Deposit in Atrophied Muscle
Authors: E. R. Bickerstaff
Journal: BMJ (1950)

EDICL JOHRNALwas not such as seriously to lead to the suspicion of alimentary obstruction, and constipation was minimal.The enema return was satisfactory and the post-partum abdo- minal distension was not significantly greater than that occasionally seen after uncomplicated childbirth.Finally, the patient was undoubtedly suffering from pre-eclampsia.
Abstract P5-08-02: New target in the resistant mechanism to trastuzumab
Authors: TT Vu, Q Zhang, L Tian, T Shackleford, T Kute, FX Claret
Journal: Cancer Research (2013)

Abstract Her2 positive (Her2+) breast cancer (BC) accounts for 18-20% of all breast cancer subtypes and is associated with high risk of death. Trastuzumab, the first Food and Drug Administration-approved targeted therapy for BC, represents a key milestone in the personalized treatment of Her2+ metastatic disease (Her2+ MBC). However, the median duration of response is less than a year, due to either primary or acquired resistance to the therapy. In addition, there is currently no conclusive biomarker for the response of patients to trastuzumab. Therefore, understanding the development of resistance to trastuzumab is of our interest. Recent studies have proposed various potential mechanisms leading to the resistance, including p27 rapid degradation. Previously, our study and other research demonstrated that Jab1 degrades p27 in breast cancer. These findings suggest that Jab1 over-expression contributes to trastuzumab resistance by facilitating p27 degradation. Jab1/CSN5 (c-Jun activation domain-binding protein 1) is over-expressed in 50% of primary and 90% of metastatic breast cancers, while its expression is low or absent in normal adult breast tissues. We previously identified that high expression of Jab1 is associated with shorter progression-free survival in breast cancer patients. In this study, our preliminary data showed that the knockdown of Jab1 sensitizes the breast cancer cells to trastuzumab treatment in a dose-dependent manner. Mechanistically, we found that Jab1 over-expression is significantly correlated with the activation of Akt pathway in Her2+ breast cancer cells and xenograft model. Interestingly, activated Akt, due to PTEN loss or PI3K activating mutation has been widely implicated in the potential mechanism to trastuzumab resistance. Therefore, our results suggest that targeting Jab1 overcomes the resistance to trastuzumab via interfering with PI3K/Akt pathway. In general, our study identifies Jab1 as a novel contributor to trastuzumab resistance and elucidates its potential mechanisms of actions. The successful completion of the study can potentially be translated to the clinic for the benefit of patients refractory to the therapy. Also our study suggests Jab1 expression level can be used as a predictive marker for trastuzumab treatment. Citation Information: Cancer Res 2013;73(24 Suppl): Abstract nr P5-08-02.
Incidence of malaria and efficacy of oral quinine in patients recently infected with human immunodeficiency virus in Kinshasa, Zaire
Authors: R. Colebunders, Y. Bahwe, W. Nekwei, R. Ryder, J. Perriens, K. Nsimba, A. Turner, H. Francis, I. Lebughe, P. Van der Stuyft, P. Piot
Journal: Journal of Infection (1990)
Basement Membrane Production by Hepatocytes in Chronic Liver Disease
Authors: Francesco B. Bianchi, Graziella Biagini, Giorgio Ballardini, Giovanna Cenacchi, Augusto Faccani, Emilio Pisi, Renzo Laschi, Lance Liotta, Spiridione Garbisa
Journal: Hepatology (1984)

The immunohistologic distribution of fibronectin, laminin, type IV collagen and whole basement membrane was evaluated in liver biopsies from patients with chronic active liver disease. Fibronectin was consistently increased in the areas of piecemeal necrosis, portal tracts and fibrous septa. Laminin was not detected in normal liver parenchyma. In contrast, laminin positive linear basement membrane structures were prevalent in portal tracts, fibrous septa and the peripheral sinusoids of cirrhotic nodules. In areas of piecemeal necrosis, the hepatocytes, single or assembled in "rosettes", were frequently underlined by linear deposits of laminin and type IV collagen. This immunoreactivity was often polarized, being confined to the stromal side of liver cells, while the parenchymal side was negative for both proteins. Electron microscopy revealed a typical basement membrane in corresponding areas. Hepatocytes normally do not produce a basement membrane, but do so following chronic injury. We suggest that the polarized basement membrane accumulation by hepatocytes is a hallmark of hepatocyte regeneration following damage.
TCT-137 Effective thrombectomy reduces no-reflow and in-hospital mortality frequency in patients with anterior ST elevation myocardial infarction undergoing primary percutaneous coronary intervention
Authors: TANER SEKER, MUSTAFA GUR, CANER TURKOGLU, Hakan Uçar, Abdurrezzak Borekci, ömer şen, DURMUS Y SAHIN, OYTUN A BAYKAN, mevlüt koç, Murat Cayli
Journal: Journal of the American College of Cardiology (2014)
Use of nutritional supplements by elite adult Portuguese athletes is not associated with nutritional intake
Authors: M Sousa, M J Fernandes, P Moreira, V H Teixeira
Journal: British Journal of Sports Medicine (2010)

This study aimed to characterise the nutritional intake according the use of nutritional supplements (NS) by elite adult Portuguese athletes. Two hundred and two adult (23±4 years) athletes (78% males), representatives of Portugal in 13 sports, voluntarily filled a semiquantitative food-frequency questionnaire and a questionnaire about the use of NS. The total nutritional daily intake did not consider the nutrients provided by NS. Statistical analyses were performed using SPSS V.16.0. The majority of athletes (74%) reported having used at least one NS in the previous year, with a mean consumption of 5.9±3.7 NS per athlete. The most frequently consumed nutritional supplements were sport drinks (63%), proteins (58%), magnesium (56%), iron (30%), vitamin C (29%), sport gels (23%), antioxidants (21%), vitamin B12 (15%) and vitamin E (9%). The mean energy intake was 2875±1313 kcal/days, for males, and 2612±1152 kcal/days, for females. For proteins, the males' intake was 1.7±0.8 g/kg/days and females' intake was 2.1±1.2 g/kg/days. Males consumed 4.8±2.5 g/kg/days of carbohydrates, while females consumed 5.6±2.6 g/kg/days. Intake of less than recommended was observed in 33% for vitamin E in females, and 17% for vitamin E, 5% for folate and 5% for magnesium, in male athletes. For all other micronutrients intakes were above recommended amounts for both genders. There were no differences in the vitamin and mineral intake between supplement users and nonusers, for both genders. The use of NS is very prevalent in elite adult Portuguese athletes and not associated with nutritional total intake.
Cell-Based Gene Transfer of Vascular Endothelial Growth Factor Attenuates Monocrotaline-Induced Pulmonary Hypertension
Authors: Andrew I.M. Campbell, Yidan Zhao, Reena Sandhu, Duncan J. Stewart
Journal: Circulation (2001)

Background Pulmonary arterial hypertension is characterized by increased pulmonary vascular resistance secondary to a decrease in the caliber and number of pulmonary vascular channels. We hypothesized that the targeted overexpression of an angiogenic factor within the lung would potentially minimize the development and progression of pulmonary arterial hypertension by preventing the loss of existing vessels or by inducing the development of new blood vessels within the lung. Methods and Results We used a cell-based method of gene transfer to the pulmonary microvasculature by delivering syngeneic smooth muscle cells overexpressing vascular endothelial growth factor (VEGF)-A to inbred Fisher 344 rats in which pulmonary hypertension was induced with the pulmonary endothelial toxin monocrotaline. Four weeks after simultaneous endothelial injury and cell-based gene transfer, right ventricular (RV) hypertension and RV and vascular hypertrophy were significantly decreased in the VEGF-treated animals. Four weeks after gene transfer, the plasmid VEGF transcript was still detectable in the pulmonary tissue of animals injected with VEGF-transfected cells, demonstrating survival of the transfected cells and persistent transgene expression. In addition, delay of cell-based gene transfer until after the development of pulmonary hypertension also resulted in a significant decrease in the progression of RV hypertension and hypertrophy. Conclusions These results indicate that cell-based VEGF gene transfer is an effective method of preventing the development and progression of pulmonary hypertension in the monocrotaline model and suggest a potential therapeutic role for angiogenic factors in the therapy of this devastating disease.
Does halothane anaesthesia decrease the metabolic and endocrine stress responses of newborn infants undergoing operation?
Authors: K. J S Anand, W G Sippell, N M Schofield, A Aynsley-Green
Journal: BMJ (1988)

Concern about the side effects of various anaesthetic agents in newborn infants has led to the widespread use of anaesthesia with unsupplemented nitrous oxide and oxygen with muscle relaxants in such patients. To investigate the efficacy of such a regimen 36 neonates undergoing operations were randomised to two groups: one group received anaesthesia with nitrous oxide and curare alone and the other was additionally given halothane. Concentrations of metabolites and hormones were measured before and at the end of operation and at six, 12, and 24 hours after operation and the values compared between the two groups. Neonates given halothane anaesthesia showed decreased hormonal responses to operation, with significant differences between the two groups in the changes in adrenaline, noradrenaline, and cortisol concentrations and the ratio of insulin to glucagon concentration. Changes in blood concentrations of glucose and total ketone bodies and plasma concentrations of non-esterified fatty acids were also decreased in neonates receiving halothane anaesthesia. Neonates given anaesthesia with unsupplemented nitrous oxide showed significantly greater increases in the urinary ratio of 3-methylhistidine to creatinine concentration and their clinical condition was also more unstable during and after operation. Unless specifically contraindicated potent anaesthesia with halothane or other anaesthetic agents should be given to all neonates undergoing surgical operations as it decreases their stress responses and improves their clinical stability during and after operation.
Hepatic Uptake of Technetium-99m Diphosphonate in Thalassemia Major
Authors: HOWARD M. LEVY, ROBERT SMITH
Journal: Clinical Nuclear Medicine (1986)

Two cases of thalassemia major are presented in which bone scintigraphy demonstrated diffuse hepatic uptake of Tc-99m diphosphonate. Although abnormal splenic and renal uptake of Tc-99m phosphates has been reported in patients with thalassemia major, hepatic uptake has not been reported previously. This scintigraphic finding is presumably due to increased iron deposition in the liver, resulting from increased iron turnover and retention in these patients and from multiple previous blood transfusions.