Age and Routine Invasive Management of Acute Coronary Syndromes
Authors: Richard G. Bach, Christopher P. Cannon, Eugene Braunwald
Journal: Annals of Internal Medicine (2004)

Letters21 December 2004Age and Routine Invasive Management of Acute Coronary SyndromesRichard G. Bach, MD, Christopher P. Cannon, MD, and Eugene Braunwald, MDRichard G. Bach, MDFrom Washington University School of Medicine, St. Louis, MO 63110, and Brigham and Women's Hospital, Boston, MA 02482.Search for more papers by this author, Christopher P. Cannon, MDFrom Washington University School of Medicine, St. Louis, MO 63110, and Brigham and Women's Hospital, Boston, MA 02482.Search for more papers by this author, and Eugene Braunwald, MDFrom Washington University School of Medicine, St. Louis, MO 63110, and Brigham and Women's Hospital, Boston, MA 02482.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-141-12-200412210-00020 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail IN RESPONSE:Dr. Masoodi raises 2 points about our analysis of outcome according to age among patients with non–ST-segment elevation acute coronary syndromes who were randomly assigned to early invasive versus conservative management. The first pertains to the lack of data on cognitive status of trial participants. While cognitive status was not specifically quantified among the baseline patient characteristics, according to the protocol, patients included in the trial needed to be considered candidates for coronary angiography and revascularization, and we excluded patients who had any “clinically important neurologic disorder” or who were unable to provide informed consent. It is thus ...References1. Anderson HV, Cannon CP, Stone PH, Williams DO, McCabe CH, Knatterud GL, et al. One-year results of the Thrombolysis in Myocardial Infarction (TIMI) IIIB clinical trial. A randomized comparison of tissue-type plasminogen activator versus placebo and early invasive versus early conservative strategies in unstable angina and non-Q wave myocardial infarction. J Am Coll Cardiol. 1995;26:1643-50. [PMID: 7594098] MedlineGoogle Scholar2. Invasive compared with non-invasive treatment in unstable coronary-artery disease: FRISC II prospective randomised multicentre study. FRagmin and Fast Revascularisation during InStability in Coronary artery disease Investigators. Lancet. 1999;354:708-15. [PMID: 10475181] CrossrefMedlineGoogle Scholar3. Wallentin L, Lagerqvist B, Husted S, Kontny F, Stahle E, Swahn E. Outcome at 1 year after an invasive compared with a non-invasive strategy in unstable coronary-artery disease: the FRISC II invasive randomised trial. FRISC II Investigators. Fast Revascularisation during Instability in Coronary artery disease. Lancet. 2000;356:9-16. [PMID: 10892758] CrossrefMedlineGoogle Scholar Author, Article, and Disclosure InformationAuthors: Richard G. Bach, MD; Christopher P. Cannon, MD; Eugene Braunwald, MDAffiliations: From Washington University School of Medicine, St. Louis, MO 63110, and Brigham and Women's Hospital, Boston, MA 02482. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoThe Effect of Routine, Early Invasive Management on Outcome for Elderly Patients with Non–ST-Segment Elevation Acute Coronary Syndromes Richard G. Bach , Christopher P. Cannon , William S. Weintraub , Peter M. DiBattiste , Laura A. Demopoulos , H. Vernon Anderson , Paul T. DeLucca , Elizabeth M. Mahoney , Sabina A. Murphy , and Eugene Braunwald Age and Routine Invasive Management of Acute Coronary Syndromes Nasseer A. Masoodi Metrics 21 December 2004Volume 141, Issue 12 Page: 967-968 Keywords Acute coronary syndrome Cognitive impairment Coronary revascularization Elderly Ischemia Life expectancy Myocardial infarction Quality of life Revascularization Stable coronary artery disease ePublished: 21 December 2004 Issue Published: 21 December 2004 Copyright & PermissionsCopyright © 2004 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...