HETEROPHILE ANTIBODY REACTION CAUSED BY BACTERIAL INFECTION
Authors: S. Bornstein
Journal: Annals of Internal Medicine (1942)

Article1 March 1942HETEROPHILE ANTIBODY REACTION CAUSED BY BACTERIAL INFECTIONS. BORNSTEIN, M.D.S. BORNSTEIN, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-16-3-472 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptA human serum was found to contain a high titer of heterophile antibodies even though the patient suffered neither from serum sickness nor from infectious mononucleosis (so-called false Paul-Bunnell reaction). This observation and the results obtained from the study of the antibodies involved, seem to be worth reporting because such reactions are very rare. Also, for the first time, it was possible in this case to explain the serological phenomenon on the basis of an infection with a bacterium containing heterophile antigen.Sheep hemolysins and agglutinins occurring after immunization with an antigen which is present in the tissues of various...References1. FORSSMAN J: Die Herstellung hochwertiger spezifischer Schafhaemolysine ohne Verwendung von Schafblut, Biochem. Ztschr., 1911, xxxvii, 78-115. Google Scholar2. FRIEDEMANN U: Ueber heterophile Normalamboceptoren. Ein Beitrag zur Lehre von der Entstehung der normalen Antikoerper, Biochem. Ztschr., 1917, lxxx, 333-356. Google Scholar3. HANGANUTZIU M: Hémagglutinins hétérogénétiques après injection de sérum de cheval, Compt. rend. Soc. de biol., 1924, xci, 1457-1459. Google Scholar4. DEICHER H: Ueber die Erzeugung heterospezifischer Haemagglutinine durch Injektion artfremden Serums, Ztschr. f. Hyg. u. Infektionskr., 1926, cvi, 561-579. CrossrefGoogle Scholar5. 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PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byThermostability of heterophile antibodies from human sera infected with Schistosoma mansoni and geo-helminths: an immuno-metric statistical analysisHeterophile antibodies and antigens in neoplastic diseasesBacterium Alcaligines (Alcaligines faecalis) Infections in Man 1 March 1942Volume 16, Issue 3Page: 472-479KeywordsAgglutininsAntigensBacteriologySerology ePublished: 1 December 2008 Issue Published: 1 March 1942 PDF downloadLoading ...