tbuckley/cabot-search huggingface dataset:
Guanine, mite, and cockroach allergens in Costa Rican homes
Authors: M. E. Soto‐Quiros, A. Ståhl, O. Calderon, C. Sanchez, L. Å. Hanson, L Belin
Journal: Allergy (1998)

Previous studies of schoolchildren in Costa Rica have shown an asthma prevalence of 23% and a high level of sensitization, particularly to mite allergens. As a continuation of these studies, some 400 dust samples were collected from various places in Costa Rica, and parts of these were analyzed for specific mite and cockroach allergens, as well as for the number of mites and amount of guanine. Guanine was quantified by a diazo, as well as an HPLC method, which were found to be highly correlated. The concentrations of guanine by the diazo method, Der p 1, Der f 1, and the number of mites were higher in bed dust than in bedroom floor dust, and it was possible to quantify mite allergens and guanine in almost all bed‐dust samples. The mean levels were 2–3 times higher than the proposed risk level for elicitation of symptoms in mite‐sensitive asthmatics. Bed and bedroom floor dust contained more guanine and mite allergen in humid (&gt;2000 mm rain) than in drier places ( P &amp;0.05), but the number of mites in bed and bedroom floor dust was higher in less humid places ( P =0.01). The guanine content in bedroom floor dust was higher in areas with a temperate climate than in areas with a warmer climate ( P &lt;0.001, Bartlett's chi square [BCS]), as was the number of mites ( P &lt;0.01, Kruskal‐Wallis [KW], 0.04, BCS) and the Der p 1 concentration ( P &lt;0.01, BCS; P =0.02, KW). The Der f 1 concentration in bedroom floor dust was higher in a warmer than in a temperate climate ( P &lt;0.001, BCS). More guanine and mites were found in urban than in rural bed dust ( P &lt;0.03, KW). Dust samples from the metropolitan area (temperate climate) of Costa Rica contained higher levels of guanine ( P &lt;0.01) and Der p 1 ( P &lt;0.07) than the coastal areas, but very little Der f 1. In these samples, guanine and Der p 1 allergen were closely related, and 2 μg of the allergen was equivalent to 0.49 mg of guanine. Two‐thirds of bed and floor samples collected on cotton filters contained Bla g 2 allergen at mean levels of 1.6 and 2.1 units/g dust, respectively. Cockroach allergen was, however, absent in all bed samples from the metropolitan area, but did occur in very high concentrations in the coastal bed dust samples collected with tighter polyester filters. In conclusion, the concentration of guanine and Der p 1 was very high in the bed dust of Costa Rican homes. Some factors, such as humidity, small houses for large families, and type of bedding, probably favored the heavy mite infestation, which is probably related to the widespread occurrence of bronchial asthma in this country.
Late Occurrence of Subacute Bacterial Endocarditis with Closed Atrial Septal Defect
Authors: Helen B. Taussig, Nicholas J. Fortuin
Journal: Annals of Internal Medicine (1973)

Letters1 April 1973Late Occurrence of Subacute Bacterial Endocarditis with Closed Atrial Septal DefectHELEN B. TAUSSIG, M.D., NICHOLAS J. FORTUIN, M.D.HELEN B. TAUSSIG, M.D.Search for more papers by this author, NICHOLAS J. FORTUIN, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-78-4-609_1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: This letter reports the occurrence of subacute bacterial endocarditis 16 years after closure of an atrial septal defect of the ostium secundum type.Patient H.W. (JHH. #145 65 18) a white, postgraduate female law student, was born October 1946 with an atrial septal defect of the ostium secundum type. Cardiac catheterization at age 7 years confirmed the diagnosis. At 10 years of age she had the defect closed by Dr. John Kirklin, with the use of the Well technique and a Teflon patch. The patient remained well for 16 years with the exception of occasional respiratory infections... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited bySmall Intestinal Submucosa Intracardiac Patch: An Experimental Study 1 April 1973Volume 78, Issue 4Page: 609-609KeywordsAtrial septal defectCatheterizationEndocarditisUpper respiratory tract infections Issue Published: 1 April 1973 PDF downloadLoading ...
Acquired Bleeding Diathesis in a Patient Taking PC-SPES
Authors: Mark C. Weinrobe, Bruce Montgomery
Journal: New England Journal of Medicine (2001)

To the Editor: Ridker and colleagues (June 28 issue) 1 demonstrated that the rate of acute coronary events among subjects with a base-line low-density lipoprotein (LDL) cholesterol level below 149.1 mg per deciliter and a C-reactive protein level above 0.16 mg per deciliter was higher among those given placebo than among those treated with lovastatin in the Air Force/Texas Coronary Atherosclerosis Prevention Study (AFCAPS/TexCAPS).The authors conclude that C-reactive protein measurements may be useful in targeting statin therapy in patients with relatively low lipid levels.This conclusion is based on a difference of 15 events between the treatment groups and is unlikely to be valid.The interpretation of the C-reactive protein level is wholly dependent on the subsequent use of aspirin, as Ridker and colleagues previously demonstrated in the Physicians' Health Study. 2 The relation between the subsequent nonuse of aspirin and the inflation of the relative risk associated with the high C-reactive protein level is a form of effect modification.Once effect modification has been found, it should be handled in all future analyses by stratification -in this case, according to the use or nonuse of aspirin.Simply put, the authors must demonstrate that it was the high C-reactive protein level, and not the nonuse of aspirin, that created the 15-event difference.It is disturbing that Ridker and colleagues continue to publish analyses of a variety of data sets and fail to account for aspirin use, hence inflating the perceived value of C-reactive protein as a tool for risk prediction.Conventional risk factors have stood the test of time because of their independence from other risk factors and concurrent therapy.Given that the relative risk associated with elevated levels of C-reactive protein is increased by the nonuse of aspirin and that the level of C-reactive protein falls with statin therapy, it is unlikely that C-reactive protein will be useful for the valid prediction of cardiovascular risk.
Survey of paramedic skills in the United Kingdom and Channel Islands
Authors: H. K Simpson, G. B Smith
Journal: BMJ (1996)

Our findings resemble the secular trends of hip fractures in Finland: their incidence nearly trebled between 1970 and 1993, and the age specific incidences increased in both sexes and in all age groups.'The reasons for the increase in osteoporotic fractures are not known.For hip fractures, the usual explanations are decreased bone mass and density (decreased bone strength) and the increased propensity of elderly people to fall (impaired balance, coordination, reaction time, and muscle strength).'In other words, it has been suggested that elderly people may be less healthy and func- tionally less capable today than in the past.If the incidence of fractures continues to increase at the same rate the annual number of first osteoporotic fractures of the proximal humerus in Finland will be about 1000 by the year 2000.However, the largest Finnish age cohorts will reach the average age for osteoporotic fractures of the proximal humerus between the years 2020 and 2030, and thus the number of these fractures is expected to increase exponentially during this period.Therefore, vigorous preventive measures, such as preventing osteoporosis and falls in elderly people, should be urgently adopted to control the increasing burden of these age related fractures.
Necrotizing sarcoid granulomatosis with extrapulmonary involvement
Authors: R S Dykhuizen, C C Smith, M M Kennedy, K A McLay, J S Cockburn, K M Kerr
Journal: European Respiratory Journal (1997)

Pulmonary lesions, with sarcoid-like granulomas exhibiting noncaseous necrosis, with associated granulomatous arteritis fulfil the diagnostic criteria of necrotizing sarcoid granulomatosis (NSG). We report the case of a woman who presented with recurrent headaches, transient right hemipareses and left-sided ophthalmoplegia. An excised left retro-orbital lesion demonstrated sarcoid like changes, and the illness responded to steroid therapy. Twelve years later, the patient developed a tumour in the right lung. The resected specimen showed the histological hallmarks of NSG, and careful review of the retro-orbital lesion, removed 12 years previously, revealed similar histology. Extrapulmonary involvement in NSG is rare and has been histologically proven on only one previous occasion. The presentation of necrotizing sarcoid granulomatosis in two different systems 12 years apart is unusual and was considered worth reporting.
Blood Cultures in Rheumatoid Arthritis: Historical and Personal Observations
Authors: T. N. Fraser
Journal: Annals of the Rheumatic Diseases (1943)

THE problem of microbic infection in relation to the aetiology of rheu- matoid arthritis has led to much discussion and experiment.Evidence of infection, particularly by streptococci, has been sought for both directly by blood cultures and indirectly by the study of immunity reactions of different kinds.The result of all this body of work remains entirely inconclusive, and it may seem redundant to burden the literature with further negative and inconclusive results.While ,carrying out intensive observations on a group of cases of rheumatoid arthritis, however, a good opportunity was presented of repeating previous observations on blood cultures on this disease, and these have been contrasted in Table I. with the results of the majority of previous workers in this field.The observations on blood cultures which have undoubtedly copyright.
Consensus in Clinical Nutrition
Authors: J Powell-Tuck
Journal: Gut (1994)

The effect of nicardipine, a new dihydropyridine calcium antagonist, on postprandial colonic motility was assessed in 10 patients with irritable bowel syndrome. Each patient was studied twice receiving intravenously either N saline or nicardipine after a 1000 calorie meal. In the control study there was a significant (p less than 0.01) postprandial increase in the contractile activity of the colon, reaching a peak at approximately 20 minutes. Intravenous nicardipine completely abolished the colonic response, with a significant reduction in the number (p less than 0.005) and amplitude (p less than 0.005) of contractions and of the motility index (p less than 0.025). These results support the need for further studies to evaluate the therapeutic role of nicardipine in the irritable bowel syndrome.
Sonographic Quantitative Evaluation of Scrotal Veins in Healthy Subjects: Normative Values and Implications for the Diagnosis of Varicocele
Authors: Alessandro Cina, Marco Minnetti, Tommaso Pirronti, Maria Vittoria Spampinato, Adolfo Canadè, Giulio Oliva, Domenico Ribatti, Lorenzo Bonomo
Journal: European Urology (2006)
Abstract 3033: Profiling of global changes in microRNA levels during adipocyte differentiation by real-time PCR
Authors: Thomas Sebastian, Elica Dhundia, Subrahmanyam Yerramilli, Eric Lader
Journal: Cancer Research (2010)

Abstract We have used a novel real time PCR approach to profile global changes in microRNA expression during adipocytic differentiation of 3T3-L1 fibroblast cells. This profiling strategy makes use of a novel two stage screen resulting in a substantial increase in throughput and decrease in reagent use. In the first step, cDNA is prepared from individual samples of undifferentiated fibroblast, and cells at early and late stages of Adipocyte differentiation. A pooled cDNA sample prepared by pooling equimolar amounts of individual cDNAs was used in an initial profiling experiment to identify microRNAs that are expressed at detectable levels in the experimental system. Profiling was performed in triplicate with real time PCR assays for 591 mouse miRNAs (miRBase v12.0). In the second stage of screening, individual cDNA samples were each analyzed in triplicate using the assays for miRNAs that showed expression in the pooled cDNA sample. Expression data was normalized against a panel of small non-coding RNAs and was expressed as x-fold changes relative to expresion in undifferentiated 3T3L1 cells. Our results indicate that 192 (∼32%) miRNAs described in miRBase v12.0 were detectable in resting and differentiated 3T3-L1 cells, and of these, 38 (or 20%) showed differential regulation during adipogenesis (x-fold change&amp;gt;3.0). When compared to data from previous array-based profiling studies, our screen identified additional differentially regulated miRNAs. In addition to profiling changes in mature miRNA levels, miRNA precursor stem loop transcripts were also quantified to gain insight into post transcriptional regulation (if any) of miRNA biogenesis during adipocyte differentiation. The high specificity and sensitivity of the miScript RT-PCR system, together with a novel sample-pooling strategy makes this system a method of choice for miRNA expression profiling. Pooled primary profiling can substantially reduce the total number of PCR reactions which need to be performed and increases assay throughput. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 101st Annual Meeting of the American Association for Cancer Research; 2010 Apr 17-21; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2010;70(8 Suppl):Abstract nr 3033.
Radiotelemetering studies of jejunal pH before and after vagotomy and pyloroplasty.
Authors: J D Maxwell, W C Watson, J K Watt, A Ferguson
Journal: Gut (1968)

Disorders of small bowel function after gastric surgery are well recognized and occur even after vagotomy and drainage procedures (Logan, 1964).Various aetiological factors have been suggested.They include altered motility, inadequate mixing of food and digestive enzymes, diminished pancreatic secretion, and the effect of blind or stagnant loops.Watson, Watt, Paton, Glen, and Lewis (1966) suggested that changes in pH in the small bowel might contribute to disorders of small bowel function after gastric surgery, and investigated changes in jejunal pH following gastroenterostomy and total vagotomy, using pH-sensitive radiocapsules.A complicating factor in this study was that the position of the recording capsule in the jejunum with respect to the acid and alkaline sources was reversed after operation.This prompted the present study on patients with vagotomy and pyloroplasty, as this operation does not alter the anatomical relationship between the stomach and small bowel. SUBJECTSNine male patients, with typical ulcer histories and radiological findings consistent with chronic duo- 7-Stomach pH
The Relationship Between Socioeconomic Status and Diabetes Control and Complications in the EURODIAB IDDM Complications Study
Authors: Nishi Chaturvedi, Judith M Stephenson, John H Fuller
Journal: Diabetes Care (1996)

To determine whether there are socioeconomic differences in diabetes control and complications in people with IDDM.We conducted a prevalence survey of 1,217 men and 1,170 women with IDDM age 25-60 years from European clinics. Age at completion of education defined socioeconomic status: < or = 14 years defined those with primary education; 15-18 years, as secondary education; and > 19 years, as college education. Glycemic control, lipids, diet, retinopathy, neuropathy, and heart disease were assessed centrally.People with a primary education were older and had diabetes for longer than those with a college education. The mean percentage of HbA1c was worst in the primary-educated men (6.6 vs. 6.1%, P = 0.0007 for trend) and women (6.5 vs. 6.0%, P = 0.0007). Total cholesterol level was higher in primary-educated than in college-educated men (5.6 vs 5.3 mmol/l, P = 0.002), as was triglyceride level (1.23 vs. 1.02 mmol/l, P = 0.0001). College-educated people were the least likely to be current smokers (P < 0.0001), and were most likely to partake in vigorous exercise (P < 0.001). Surprisingly, There was little difference in the prevalence of heart disease by educational status in men, while it was highest in the least educated women, but proliferative retinopathy was more common in primary- than in college-educated men (16 vs 10%, P = 0.04) as was macroalbuminuria (15 vs 9%, P = 0.03). Glycemic control could not fully account for these differences.Healthy lifestyles are more prevalent in better educated men and women with IDDM, but these are not reflected in heart disease prevalence in men. The lower prevalence of severe microvascular complications in better educated men, unaccounted for by better glycemic control, requires further investigation.
THE WORK OF A VENEREAL DISEASE CLINIC
Authors: O. L. Rhys
Journal: BMJ (1919)

PRIMARY SARCOMA OF THE -LI-VER.treatment,even it rather prolonged, in preference to a formidable operation from wlhich they would naturally shrink.Several of the cases are of three and four years' standing, yet notle of thlose discharged cured have returned, and a few have written letters saying how well they still feel.
FGFR3 Stimulates Stearoyl CoA Desaturase 1 Activity to Promote Bladder Tumor Growth
Authors: Xiangnan Du, Qian-Rena Wang, Emily Chan, Mark Merchant, Jinfeng Liu, Dorothy French, Avi Ashkenazi, Jing Qing
Journal: Cancer Research (2012)

Fibroblast growth factor receptor 3 (FGFR3) belongs to a family of receptor tyrosine kinases that control cell proliferation, differentiation, and survival. Aberrant activation of FGFR3 via overexpression or mutation is a frequent feature of bladder cancer; however, its molecular and cellular consequences and functional relevance to carcinogenesis are not well understood. Through transcriptional profiling of bladder carcinoma cells subjected to short hairpin RNA knockdown of FGFR3, we identified a gene-signature linking FGFR3 signaling with de novo sterol and lipid biosynthesis and metabolism. We found that FGFR3 signaling promotes the cleavage and activation of the master transcriptional regulator of lipogenesis, sterol regulatory element-binding protein 1(SREBP1/SREBF1), in a PI3K-mTORC1-dependent fashion. In turn, SREBP1 regulates the expression of key lipogenic enzymes, including stearoyl CoA desaturase 1 (SCD1/SCD). SCD1 is the rate-limiting enzyme in the biosynthesis of monounsaturated fatty acids and is crucial for lipid homeostasis. In human bladder cancer cell lines expressing constitutively active FGFR3, knockdown of SCD1 by siRNA markedly attenuated cell-cycle progression, reduced proliferation, and induced apoptosis. Furthermore, inducible knockdown of SCD1 in a bladder cancer xenograft model substantially inhibited tumor progression. Pharmacologic inhibition of SCD1 blocked fatty acid desaturation and also exerted antitumor activity in vitro and in vivo. Together, these findings reveal a previously unrecognized role of FGFR3 in regulating lipid metabolism to maintain tumor growth and survival, and also identify SCD1 as a potential therapeutic target for FGFR3-driven bladder cancer.
Multiple System Atrophy and Repeat Expansions in<i>C9orf72</i>
Authors: Lucia V. Schottlaender, Janice L. Holton, Henry Houlden
Journal: JAMA Neurology (2014)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Neurology HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Neurology journal
Abstract 1440: Validation of potential therapeutic targeting of IL-6/JAK/STAT3 pathway by AZD1480 in neuroblastoma and other pediatric tumors
Authors: Shuang Yan, Carol J Thiele
Journal: Cancer Research (2012)

Abstract Neuroblastoma is the most deadly extra-cranial solid childhood tumor. Despite advanced therapies, over 60% of high-risk NB patients have aggressive tumors spreading to bone and bone marrow and die of metastasis-related disease. IL-6 promotes the growth and survival of metastatic NB cells via activation of STAT3 in the BM and is an independent poor-prognosis marker in tumors from high-risk NB patients. This suggests that blockade of IL6/JAK/STAT3 signaling may represent a promising therapeutic strategy. We tested the anti-tumor effect of inhibition IL6/JAK/STAT3 pathway by the JAK1/2 inhibitor AZD1480, which is in Phase II clinical trials in adult tumors, in three highly metastatic pediatric tumor types (Neuroblastoma, Ewing sarcoma and rhabdomyosarcoma). AZD1480 (0.5uM) significantly blocked IL-6-induced P-STAT3-Tyr705 in all tumor types tested. AZD1480 decreased cell viability in the 6 NB, 5 RMS and 2 EWS cell lines tested (median IC50 1.17uM, ranging from 0.42-5.1uM). AZD1480 induced cell growth inhibition, G2 arrest and apoptosis in vitro. Moreover, AZD1480 inhibited the expression of identified direct STAT3 targets such as cell cycle regulators CyclinD2, CyclinD3 and CDC25A, antiapoptotic proteins Bcl-2 and Survivin, metastasis-related protein TIMP-1 and c-myc consistent with its repression of cell growth, induction of G2 arrest and apoptosis. In in vivo Neuroblastoma xenograft models, AZD1480 suppressed growth of SY5Y and KCNR xenografts and increased survival of mice bearing KCNR xenografts (P=0.0001) and SY5Y xenografts (P=0.02). Altogether, these data suggest the clinical blockade of IL6/JAK/STAT3 signaling by AZD1480 may represent a promising new therapy in NB and other pediatric tumors. We thank Dennis Huszar and AstraZeneca for the AZD1480 and helpful discussions. Key words: neuroblastoma, JAK2, STAT3, IL-6, targeted therapy Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 103rd Annual Meeting of the American Association for Cancer Research; 2012 Mar 31-Apr 4; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2012;72(8 Suppl):Abstract nr 1440. doi:1538-7445.AM2012-1440
Cost Containment and the Physician
Authors: Larry A. O'Brien
Journal: JAMA (1986)

<h3>To the Editor.—</h3> Dr Angell,<sup>1</sup>in her article, "Cost Containment and the Physician," outlines the growth of unnecessary medical care and the role of physicians in containing medical costs. A factor that is suggested as crucial is a "revision of fee schedules so that they no longer reward the use of tests and procedures." Dr Angell made it clear before this statement that she was not accusing the majority of physicians of performing "unnecessary tests and procedures simply to make money." I believe she is correct that the majority of physicians do not order tests simply to make money, but there are two significant reasons these tests are ordered. The first reason is society's expectations for these "little-ticket items." Common are lay accounts of initial vague symptoms that are appropriately dismissed as transient phenomena by a physician (eg, headaches). Later that patient sees another physician who, perhaps with relevant