tbuckley/cabot-search huggingface dataset:
BRONCHOLITHIASIS: REPORT OF TEN CASES
Authors: J R FOX, L H CLERF
Journal: Annals of Internal Medicine (1945)

Article1 December 1945BRONCHOLITHIASIS: REPORT OF TEN CASESJ. ROBERT FOX, M.D., LOUIS H. CLERF, M.D., F.A.C.P.J. ROBERT FOX, M.D.Search for more papers by this author, LOUIS H. CLERF, M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-23-6-955 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptBroncholiths have been recognized in medical literature for centuries.1In our time, with the impetus medical diagnosis has been given by improved technic in bronchology, roentgenology and biochemical analysis, this entity has changed its disposition from that of a medical curiosity to one of an accurately conceived disease. Because of the relative infrequency with which this disease occurs, broncholithiasis has often been neglected in the differential diagnosis of bronchial obstruction. As a result patients have found themselves erroneously classified among the more common diseases causing bronchial obstruction, thereby losing the advantage of an early diagnosis. By such delay not only...Bibliography1. PAULALION SA: Les pierres de poumon du pleure, etc., Thesis before Academy of Medicine, Paris, 1891, p. 364. Google Scholar2. WELLS HG: Calcification and ossification, Arch. Int. Med., 1911, vii, 721. CrossrefGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Philadelphia, Pennsylvania*Received for publication April 13, 1945.From the Department of Laryngology and Broncho-Esophagology, Jefferson Hospital. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byATELECTASIS OF THE RIGHT MIDDLE LOBE RESULTING FROM PERFORATION OF TUBERCULOUS LYMPH NODES INTO BRONCHI IN ADULTS*ABRAHAM G. COHEN, M.D., F.A.C.P.Expectoration of abnormal substances and particles including parasitesBRONCHOLITHIASISXC Broncholithiasis 1 December 1945Volume 23, Issue 6Page: 955-959 ePublished: 1 December 2008 Issue Published: 1 December 1945 PDF downloadLoading ...
Abstract 681: Heat shock-mediated suppression of ODC protein expression in colorectal cancer cells
Authors: Christina T.K. Wales, Aaron T. Jacobs
Journal: Cancer Research (2014)

Abstract Polyamines are small, positively charged metabolites that have important roles in several cancer hallmarks, including cell proliferation, invasion, and angiogenesis. Difluoromethylornithine (DFMO) is an FDA-approved drug that is in clinical trials for treatment of colorectal cancer. DFMO functions by inhibiting ornithine decarboxylase (ODC), which catalyzes the rate-limiting step in polyamine biosynthesis. By reducing polyamine levels, DFMO has shown much promise as an anti-cancer chemotherapeutic. One potential limitation to DFMO is that it causes a profound increase in ODC expression, which we suspect may counteract the intended use of the drug. However, strategies to suppress ODC expression would theoretically increase DFMO efficacy. We have discovered that transient hyperthermia (heat shock, 42°C) causes a profound and rapid suppression in ODC protein levels in RKO colorectal cancer cells. To investigate the responsible mechanism, we began by examining ODC mRNA expression and stability. Hyperthermia caused only a moderate reduction in ODC transcript levels. Also, mRNA stability, which was assessed using actinomycin D, was not reduced by heat shock. We next examined the effect of hyperthermia on the control of ODC protein turnover, which is known to be mediated by ODC antizyme (OAZ1). We performed real-time PCR to assess the effect of heat shock on OAZ1 expression. Data reveal a significant increase in the level of OAZ1 transcript. Since heat shock is known to activate the transcription factor HSF1, we next investigated the role of HSF1 in OAZ1 induction. Using siRNA to silence HSF1, we found that the induction of OAZ1 by heat shock is fully dependent on HSF1 expression. In addition to heat shock, HSF1 is also activated by various chemotherapeutics, but most notably by Hsp90 inhibitors. We therefore tested if Hsp90 inhibitors, geldanamycin and 17-AAG could be used to induce OAZ1 and promote ODC turnover. These results show that both Hsp90 inhibitors caused a significant activation of HSF1, an induction in OAZ1 expression, and decrease in ODC protein levels. We therefore propose that Hsp90 inhibitors may be effective in attenuating ODC expression and polyamine metabolism. We suggest that they may be used in combination with DFMO to prevent the compensatory increase in ODC levels and increase anti-cancer effects. Citation Format: Christina T.K. Wales, Aaron T. Jacobs. Heat shock-mediated suppression of ODC protein expression in colorectal cancer cells. [abstract]. In: Proceedings of the 105th Annual Meeting of the American Association for Cancer Research; 2014 Apr 5-9; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2014;74(19 Suppl):Abstract nr 681. doi:10.1158/1538-7445.AM2014-681
Postoperative deposition of calcium on the surfaces of a hydrogel intraocular lens11The authors have no financial or proprietary interest in any product mentioned in this paper.
Authors: Liliana Werner, David J Apple, Marcela Escobar-Gomez, Arne Öhrström, Basil B Crayford, Roberto Bianchi, Suresh K Pandey
Journal: Ophthalmology (2000)
Abstract 13450: Evidence of Left Atrial Appendage Isolation via the Coronary Sinus: Mechanism and Clinical Implications
Authors: Luigi Di Biase, Miguel Valdebbarrano, Javier E. Sanchez, Agnes Pump, Pasquale Santangeli, Rong Bai, Prasant Mohanty, Rodney Horton, G.Joseph Gallinghouse, Sanghamitra Mohanty, B Mauricio Cereceda, Salwa Beheiry, Richard Hongo, Douglas Gibson, J. David Burkhardt, Andrea Natale
Journal: Circulation (2011)

Introduction:  Catheter ablation of adjunctive atrial sites together with pulmonary veins isolation is required in some patients to improve the procedural success rate. AF triggers within the coronary sinus (CS) have been recognized as a potential source of atrial fibrillation. The aim of our study is to report unusual pattern of left atrial appendage isolation with ablation in the coronary sinus.   Methods:  244 consecutive patients undergoing catheter ablation for persistent or long standing persistent AF and showing firing from the coronary sinus have been enrolled in this multicenter prospective study. In all patients defragmentation of the coronary sinus to achieve isolation was attempted both with endocardial and epicardial ablation. During coronary sinus ablation, the circular mapping catheter was positioned into the left atrial appendage.   Results:  The baseline clinical characteristics were 66% male, 63±7 years, LA size 47±8mm, AF duration 75±64 months, 32% persistent, and 68% long standing persistent. In 7% of those cases (17 pts) during ablation in the mid coronary sinus simultaneous isolation of the left atrial appendage was documented. This was associated with the presence of a venous branch connecting the coronary sinus with the left atrial appendage. No periprocedural complications were reported.   Conclusion:  The results of our study highlight the presence of a distinct electrical connection between the coronary sinus and the left atrial appendage. Because of this, ablation in the mid coronary sinus can result in inadvertent isolation of the left atrial appendage. Considering the potential long term implications, ablation in the mid coronary sinus should prompt assessment of LAA conduction.
MRI for the Diagnosis and Follow-Up of Myocarditis
Authors: M. Giulia Gagliardi, Bruno Polletta, Paolo Di Renzi
Journal: Circulation (1999)

Doggen et al 1 reported a case-control study assessing the effect of factor V Leiden and the prothrombin 20210 gene variant on the risk of myocardial infarction in men.The authors stated in their conclusions that "the 20210 G3 A variant of prothrombin is associated with an increased risk of myocardial infarction" and that "the combined presence of major cardiovascular risk factors and carriership of a coagulation defect increases the risk considerably."A review of their data in Tables 1 through 4 leads us to conclude that neither claim is supported by statistical significance.In Table 2, the prevalence of the prothrombin variant in cases (1.8%) is not significantly different from the prevalence in controls (1.2%) by the 2 test, with an OR of 1.5 and a CI (0.6 -3.8) that includes unity.A larger study would be required to prove that an OR of 1.5 is truly increased.The likelihood that this OR of 1.5 is not significantly different from 1.0 is also suggested by the fact that it is based on the unexpected finding of a lower prevalence of the variant in the controls (1.2%) than in the general population(2%) rather than a higher prevalence in the cases.The second conclusion, that a coagulation defect added to the effect of a metabolic defect, also does not stand up to scrutiny of the data.In Table 3, the ORs of 6.1 and 3.3, with their overlapping CIs of 3.0 -12.5 and 2.5-4.2,respectively, indicate that smoking increased the risk of myocardial infarction, with or without a coagulation defect, but do not prove that factor V Leiden or the prothrombin variant significantly added to the risk.Without access to the original data, we cannot calculate the P value for this comparison of age-adjusted ORs, but the wide overlap of the CIs suggests that a significant difference between the 2 ORs was not found.Similar observations apply to the subset analyses of the effect of obesity and hypertension in Table 4.Only the pooled data for any "metabolic defect" and any coagulation defect, shown in Table 3, appear possibly to have achieved statistical significance.The authors should have explicitly stated the presence or absence of statistical significance for each of the comparisons of risk that they published in Tables 1 through 4, a minimum of 23 comparisons, for which a P value of Ͻ0.05 may be found at least once by chance.We conclude that the authors have not proven that the prothrombin 20210 gene variant, in the absence of factor V Leiden, increases the risk of myocardial infarction.
Report of the 1995 World Health Organization/International Society and Federation of Cardiology Task Force on the Definition and Classification of Cardiomyopathies
Authors: P Richardson, W McKenna, M Bristow, B Maisch, B Mautner, J O'Connell, E Olsen, G Thiene, J Goodwin, I Gyarfas, I Martin, P Nordet
Journal: Circulation (1996)
A male-female bias in type 1 diabetes and linkage to chromosome Xp in MHC HLA-DR3-positive patients
Authors: Francesco Cucca, Juliet V. Goy, Yoshihiko Kawaguchi, Laura Esposito, Marilyn E. Merriman, Amanda J. Wilson, Heather J. Cordell, Stephen C. Bain, John A. Todd
Journal: Nature Genetics (1998)
590. SuperCD Enables Low Dose 5-FC Application for Effective Suicide Gene Therapy in a Rat Hepatoma Model Both In Vitro and In Vivo
Authors: Marie-Luise Lemken, Florian Graepler, Wolfgang A. Wybranietz, Ulrike Schmidt, Irina Smirnow, Christine D. Gross, Martin Spiegel, Andrea Schenk, Hansjoerg Graf, Ulrike A. Lauer, Michael Gregor, Sorin Armeanu, Michael Bitzer, Ulrich M. Lauer
Journal: Molecular Therapy (2004)

S223 590. SuperCD Enables Low Dose 5-FC Application for Effective Suicide Gene Therapy in a Rat Hepatoma Model Both In Vitro and In Vivo Marie-Luise Lemken, Florian Graepler, Wolfgang A. Wybranietz, Ulrike Schmidt, Irina Smirnow, Christine D. Gross, Martin Spiegel, Andrea Schenk, Hansjoerg Graf, Ulrike A. Lauer, Michael Gregor, Sorin Armeanu, Michael Bitzer, Ulrich M. Lauer. Department of Internal Medicine I, University Clinic Tuebingen, Tuebingen, Germany; Section of Experimental Radiology, University Clinic Tuebingen, Tuebingen, Germany.
Angelhead: My Brother's Descent into Madness
Authors: Sean A Spence
Journal: BMJ (2001)

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After Greg Bottoms' brother developed a psychosis in adolescence, he was never the same. Nor was his family. “My brother saw the face of God. … He was fourteen, on LSD, shouting for help in the darkness of his room in our new suburban home. I was ten. I stood watching from his doorway, still, eyes cinched up tight as seams, trying to make out his writhing shape. I …

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Molecular analysis of lineage-specific chimerism and minimal residual disease by RT-PCR of p210BCR-ABL and p190BCR-ABL after allogeneic bone marrow transplantation for chronic myeloid leukemia: increasing mixed myeloid chimerism and p190BCR-ABL detection precede cytogenetic relapse
Authors: Josefina Serrano, Jose Roman, Joaquin Sanchez, Antonio Jimenez, Juan A. Castillejo, Concepcion Herrera, Maria Gracia Gonzalez, Luisa Reina, Maria del Carmen Rodriguez, Miguel A. Alvarez, Juan Maldonado, Antonio Torres
Journal: Blood (2000)
A national target for reducing suicide
Authors: K. Hawton
Journal: BMJ (1998)

The mental health target in the green paper Our Healthier Nation is “to reduce the death rate from suicide and undetermined injury by at least a further sixth (17%) by 2010, from a baseline at 1996.”1 The former government's Health of the Nation strategy included two suicide targets—namely, a 15% reduction in the overall suicide rate and a 33% reduction in the rate in the severely mentally ill.2 The initial suicide targets were controversial, argument centring on the advisability of a target for a relatively uncommon event (about 5000 suicides and open verdicts each year in England and Wales), the difficulty of predicting suicide, and the pressure the targets might place on psychiatric services. Nevertheless, the overall suicide rate has declined since the original targets were set. Most importantly, the previous rapid rise in suicides in men aged 15-44 years has started to reverse.1 Why do we still need a suicide target and can suicide rates be reduced further?

Suicide is usually the tragic end point of various possible pathways, influenced by mental ill health and psychological, socioeconomic, familial, interpersonal, …
A gut solution for hepatic encephalopathy
Authors: Javier Vaquero, Rafael Bañares
Journal: Hepatology (2015)

1Hepatología‐Servicio de Aparato DigestivoHospital General Universitario Gregorio MarañónMadrid, Spain 2Instituto de Investigación Sanitaria Gregorio Marañón (IiSGM)Madrid, Spain 3Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBEREHD)Instituto de Salud Carlos IIIMadrid, Spain 4Facultad de MedicinaUniversidad ComplutenseMadrid, Spain
Address of Welcome
Authors: S. H. Boyer
Journal: Annals of Internal Medicine (1930)

Article1 July 1930Address of WelcomeS. H. BOYERS. H. BOYERSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-4-1-1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptOriginally, physicians banded themselves together in order to keep their knowledge intact and their calling sacred, as witness the ancient guilds and the Oath of Hippocrates. So strong were these purposes that they have held through the centuries. Even today, though not always remembered, these purposes continue to be the chief motives that bind us together. Throughout antiquity, on through the dark ages and right down to the present time the medical profession has felt the influence of this tradition, and it has fettered us and made us feel almost as a thing apart from the social fabric in which... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Minnesota State Medical Association Duluth, Minn.*Delivered at the Minneapolis Meeting of the American College of Physicians, February 10, 1930. Nextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 July 1930Volume 4, Issue 1Page: 1-4 ePublished: 1 December 2008 Issue Published: 1 July 1930 PDF downloadLoading ...
Abstract 4440: TRAF4 is a key molecule for lung cancer through regulating AKT ubiquitination and activation
Authors: Cong Peng, Wei Li, Xiang Chen, Zigang Dong
Journal: Cancer Research (2014)

Abstract TRAF4 is a member of TRAF family. Although TRAF4 was reported to be overexpressed in cancer tissues, the role of TRAF4 in tumorigenesis remains unclear. Here, we found TRAF4 is over expressed in lung cancer cell lines as well as lung cancer tissues. Knockdown TRAF4 dramatically attenuated lung cancer malignant phenotype including cell proliferation, anchorage independent growth and tumor development in a xenograft mouse model . To our surprised, it is that TRAF4, but not skp2 is required for Akt activation through ubiquitination in lung cancer. Overall, our study suggests that TRAF4 might be a potential molecular target for lung cancer prevention and therapy. Citation Format: Cong Peng, Wei Li, Xiang Chen, Zigang Dong. TRAF4 is a key molecule for lung cancer through regulating AKT ubiquitination and activation. [abstract]. In: Proceedings of the 105th Annual Meeting of the American Association for Cancer Research; 2014 Apr 5-9; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2014;74(19 Suppl):Abstract nr 4440. doi:10.1158/1538-7445.AM2014-4440
Abstract 1659: Characterizing cytokine secretion in response to dsRNA treatment in ovarian cancer cells
Authors: Maria Muccioli, Michelle Pate, Fabian Benencia
Journal: Cancer Research (2014)

Abstract Ovarian cancer exhibits the lowest long-term survival rates amongst all gynecological cancers, warranting more research directed at finding novel therapies, especially for late-stage disease. Inflammation is known to affect cancer progression, with tumor-promoting or repressive effects possible in different contexts, where the types of leukocytes at the tumor site are heavily implicated in disease prognosis. Tumor-associated macrophages and T-regulatory cells, for example, are known to promote tumor growth by inhibiting the anti-cancer response and by secreting pro-angiogenic factors. Importantly, the specific processes and cellular signaling pathways leading up to leukocyte infiltration in different cancer types remain to be fully elucidated. We hypothesize that dsRNA in the vicinity of ovarian cancer cells (such as from a viral infection or cellular debris) can activate pro-inflammatory regulators in tumor cells, in particular the NF-KB transcription factor, the aberrant over-activation of which is implicated in many cancers. NF-KB activation results in increased production and secretion of numerous cytokines that can in turn recruit pro-angiogenic leukocytes to the tumor microenvironment, thus favoring cancer progression. Herewith, we evaluated the production of numerous cytokines after dsRNA treatment in mouse and human ovarian cancer cells. Additionally, we determined which of the four known dsRNA receptors contributes most to this process. Consistently with our hypothesis, we have shown an increase in several pro-inflammatory cytokines (eg. CCL5 and IL6) in response to dsRNA treatment in both human and mouse ovarian cancer cell lines. We have also determined that the dsRNA receptor MDA5 contributes the most to dsRNA-induced cytokine secretion in both human and mouse ovarian cancer cell lines employing siRNA-directed knock-down of each receptor. Altogether, these data suggest that dsRNA-induced signaling in ovarian cancer cells may facilitate a tumor-favoring environment; thus dsRNA-sensing receptors may constitute attractive therapeutic targets for cancer immunotherapy. Further studies in our lab will determine the specific signaling pathways responsible for the upregulated cytokines as well as use a mouse model to examine the effect of dsRNA receptor knock-down in the cancer cells on tumor growth, angiogenesis, and the leukocyte infiltration profile. Citation Format: Maria Muccioli, Michelle Pate, Fabian Benencia. Characterizing cytokine secretion in response to dsRNA treatment in ovarian cancer cells. [abstract]. In: Proceedings of the 105th Annual Meeting of the American Association for Cancer Research; 2014 Apr 5-9; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2014;74(19 Suppl):Abstract nr 1659. doi:10.1158/1538-7445.AM2014-1659
Abstract P244: Combined Measures of Total and Abdominal Adiposity and the Likelihood of Subclinical Myocardial Damage
Authors: Amira O Collison, Vijay Nambi, Mariana Lazo, Ron C Hoogeveen, Roger S Blumenthal, Aaron R Folsom, Elizabeth Selvin, Christie M Ballantyne, Josef Coresh, Chiadi E Ndumele
Journal: Circulation (2015)

Background: Obesity has been independently associated with subclinical myocardial damage. Both body mass index (BMI) and waist circumference (WC) are recommended for cardiovascular risk assessment, and they provide complementary information about heart failure (HF) risk. However, their combined relationship with subclinical myocardial damage is presently unknown. Hypothesis: We hypothesized that high measures of both BMI and WC would have the strongest association with subclinical myocardial damage, as indexed by a high-sensitivity assay for cardiac troponin T (hs-cTnT). Methods: We performed a cross-sectional analysis of 9,507 participants at ARIC Visit 4 (1996-99). We excluded individuals with prior cardiovascular disease, with BMI &lt; 18.5 kg/m2 and those not of white or black race. We created tertiles of BMI and WC (sex-specific for WC). We used logistic regression to relate combined tertiles of BMI and WC to elevated hs-cTnT (&gt; 14 ng/L) measured at Visit 4, after adjustment for confounding variables. Results: The mean age was 62 years (S.D. 6), 58% were female and 22% were black. After multivariable adjustment, each 1-SD higher of BMI (1.41 [95% CI: 1.30-1.53]) and WC (1.50 [95% CI: 1.37-1.63]) was associated with elevated hs-cTnT. In analyses using combined BMI and WC tertiles, higher WC was associated with trends towards higher associations with elevated hs-cTnT within each BMI tertile (Figure). Among those individuals in the highest 2 BMI tertiles, those who were also in the highest WC tertile demonstrated significant independent associations between the anthropometric measures and elevated hs-cTnT. Conversely, significant associations with elevated hs-cTnT were not seen for those individuals in higher BMI tertiles but lower WC tertiles. Conclusion: A combination of high BMI and WC is associated with myocardial damage more often than high BMI with lower WC. This supports using assessments of both total and abdominal adiposity to understand obesity-associated risk.
The follicular triad: a pathological clue to the diagnosis of early frontal fibrosing alopecia
Authors: M. Miteva, A. Tosti
Journal: British Journal of Dermatology (2011)

Funding sources: None. Conflicts of interest: None declared. Madam, Frontal fibrosing alopecia (FFA) is a clinical variant of lichen planopilaris (LPP), which mostly affects postmenopausal women and frequently involves the eyebrows.1 It presents as a progressive symmetric band‐like alopecia involving the frontal hairline, the preauricular and, less commonly, the retroauricular scalp. The partial or complete hair loss of the eyebrows without clinical inflammation is characteristic and occurs either before or after the onset of frontotemporal recession.2 The condition usually advances slowly (0·9 mm a month) and eventually stabilizes. There is current evidence that, in FFA, vellus or terminal hair follicles of the face, including the eyelashes, as well as extrafacial body sites may also be affected by hair loss.3 We recently reported that biopsies obtained from limb alopecia and scalp alopecia in FFA share the same histopathological features, i.e. a LPP pattern.4 This finding was confirmed by two recent publications.3, 5