tbuckley/cabot-search huggingface dataset:
P-044 Preoperative chemoradiotherapy in locally advanced esophageal carcinoma. A retrospective study from a multidisciplinary oncologic centre
Authors: M. Saigí, M. Oliva, Ò. Serra, L. Farran, M. Calvo, A.M. Boladeras, G. Hormigo, H. Aranda, J. Robles, J.B. Gornals, E. de Lama, M.J. Paúles, N. Virgili, F.J. Pérez Martín, M. Galán
Journal: Annals of Oncology (2015)
Failure of Bone Marrow to Interfere With the Augmentation of X-Ray Leukemogenesis by Urethan&lt;xref ref-type="fn" rid="FN1"&gt;2&lt;/xref&gt;
Authors: I Berenblum, F E Rewald, N Trainin
Journal: JNCI Journal of the National Cancer Institute (1961)

Ten weekly intravenous injections of isologous bone marrow into C57BL/6 mice, each injection following an intraperitoneal injection of urethan, failed to inhibit the augmentation by the urethan of leukemogenesis induced by a previous, single, total-body X irradiation of 400 r. One intravenous injection of bone marrow depressed leukemogenesis by a single dose of 400 r X irradiation without any urethan treatment. These results do not support the possibility that the urethan effect on leukemogenesis causes a depression of the bone marrow, and thus lend further weight to the idea that its action represents a promoting factor, with irradiation serving essentially as initiating factor, in the relatively low dose ranges used. When bone marrow was injected soon after the irradiation (to inhibit leukemogenesis) and urethan given subsequently, the resulting leukemia incidence was considerably higher than that obtained with irradiation alone, and almost as high as with irradiation (without bone marrow) followed by urethan. It is suggested that the inhibiting effect of normal bone marrow on X-irradiation leukemogenesis probably operates at the initiating stage.
Clinical Impact Of Post-Transplant Chimerism Monitoring In CD33/34 Bone Marrow Subpopulations and Whole Blood In Pediatric AML: Prospective Comparison Of Highly Sensitive Real Time Sequence Polymorphism PCR Versus Gold-Standard Conventional STR-PCR
Authors: Andre Manfred Willasch, Eva Rettinger, Marion Zabel, Hermann Kreyenberg, Vida Meyer, Arndt Borkhardt, Markus Metzler, Bernhard Kremens, Brigitte Strahm, Wilhelm Woessmann, Christine Mauz-Koerholz, Bernd Gruhn, Stefan Burdach, Michael H Albert, Paul G. Schlegel, Thomas Klingebiel, Peter Bader
Journal: Blood (2013)
A Classification of the Tumors of the Glioma Group on a Histogenetic Basis with a Correlated Study of Prognosis.
Authors: Percival Bailey, Harvey Cushing
Journal: JAMA (1926)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Abstract 20313: Glucagon-Like-Peptide-1 Receptor Preserves Cardiac Performance and Attenuates Remodeling Through Mkk3 in Infarcted Hearts
Authors: Jian Feng Du, Ling Zhang, Youfang Chen, Yu Zhao, Ting C Zhao
Journal: Circulation (2014)

Background:  We have demonstrated that GLP-1 protects the heart against ischemic injury. However, the physiological mechanism by which GLP-1 receptor (GLP-1R) initiates cardioprotection remains to be determined.   Objectives:  This study is sought to elucidate the role of MKK3 in mediating GLP-1R-elicited protection in infarcted hearts.   Methods:  Adult wild type (WT), MKK3-/- mice were subjected to myocardial infarction by ligation of the left anterior descending artery. Infarcted mice received a daily intraperitoneal injection of exendin-4, a GLP-1R agonist (0.1mg/kg). Echocardiography was conducted before and 3, 6, 9 weeks after the surgery. Myocardium was collected for evaluation of hypertrophy, apoptosis and angiogenesis.   Results:  Exendin-4 preserved cardiac function in WT mice, but functional improvement was not observed in MKK3-/- mice. Exendin-4 treatment induced a reduction of cardiomyocyte size and a decreased collagen deposition in infarcted WT mice only. Elimination of MKK3 abolished the anti-apoptotic effect induced by Exendin-4 in WT mice. Exendin-4 also increased capillary density in WT, but not in MKK3-/- mice. GLP-1R stimulation increased phosphorylation of MKK3, decreased active-caspase 3, poly(ADP-ribose) polymerase (PARP) and annexin V in WT, but not in MKK3-/- mice.   Conclusion:  GLP-1R stimulation improves cardiac function, reverses remodeling, and promotes angiogenesis in the infarcted myocardium through MKK3 pathway.
Abstract 12185: Time Course of the Restenosis Following Nitinol Stenting in the Superficial Femoral Artery and the Factors Associated with Early and Late Restenosis
Authors: Osamu Iida, Masaaki Uematsu, Yoshimitsu Soga, Hiroyoshi Yokoi, Masakiyo Nobuyoshi, Keisuke Hirano, Toshiya Muramatsu, Naoto Inoue, Kenji Suzuki, Shinsuke Nanto, Seiki Nagata
Journal: Circulation (2010)
Abstract 3503: Somatic mutations and aberrant expression of RNF43 are recurrently found in intraductal papillary mucinous neoplasms of the pancreas
Authors: Hitomi Sakamoto, Yuko Kuboki, Takashi Hatori, Masakazu Yamamoto, Masanori Sugiyama, Noriyuki Shibata, Kyoko Shimizu, Keiko Shiratori, Toru Furukawa
Journal: Cancer Research (2014)

Abstract Background: RNF43 encodes ring finger protein 43, an ubiquitin ligase, and is recently uncovered as mutated in intraductal papillary mucinous neoplasms of the pancreas (IPMNs). We studied mutations and aberrant expressions of RNF43 and their associations with molecular and clinicopathological features in IPMNs. Materials and methods: Studied were 178 IPMNs operated upon between 2001 and 2010 at Tokyo Women's Medical University Hospital. Formalin-fixed and paraffin-embedded tissues of the 178 cases and frozen tisssues of 56 of the cases were subjected for immunohistochemical and the next generation semiconducter sequencing analyses, respectively. Detected mutations were validated by Sanger sequencing. Results: Expression of RNF43 was reduced in 60 (33.7%) of the 178 IPMNs. Somatic mutations in RNF43 were found in 10 (17.9%) of the 56 examined cases, in which frameshift mutations, a nonsense mutation, and missense mutations were found in 5, 1, and 4 cases, respectively. These mutations were significantly associated with RNF43 expression (p = 0.008) and GNAS mutation (p = 0.012), however, not associated with tumor grade, histological subtype or prognosis. Conclusion: These results indicate that RNF43 may function as a tumor suppressor and play a role in development of IPMN. Citation Format: Hitomi Sakamoto, Yuko Kuboki, Takashi Hatori, Masakazu Yamamoto, Masanori Sugiyama, Noriyuki Shibata, Kyoko Shimizu, Keiko Shiratori, Toru Furukawa. Somatic mutations and aberrant expression of RNF43 are recurrently found in intraductal papillary mucinous neoplasms of the pancreas. [abstract]. In: Proceedings of the 105th Annual Meeting of the American Association for Cancer Research; 2014 Apr 5-9; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2014;74(19 Suppl):Abstract nr 3503. doi:10.1158/1538-7445.AM2014-3503
A High Frequency of Circulating B Cells Share Clonotypic Ig Heavy-Chain VDJ Rearrangements With Autologous Bone Marrow Plasma Cells in Multiple Myeloma, as Measured by Single-Cell and In Situ Reverse Transcriptase-Polymerase Chain Reaction
Authors: Agnieszka J. Szczepek, Karen Seeberger, Juanita Wizniak, Michael J. Mant, Andrew R. Belch, Linda M. Pilarski
Journal: Blood (1998)
Abstract 4082: CD47 blockade to enhance adaptive anti-tumor immune responses
Authors: Katie L. Anderson, Daisuke Ito, Debra C. Lins, Julie M. Curtsinger, Matthew F. Mescher, Jaime F. Modiano
Journal: Cancer Research (2014)

Abstract The success of immunotherapy has been hindered by the ability of tumors to evade or inhibit the host immune system. One strategy tumors use to achieve this is upregulation of CD47, a cell surface protein that delivers a “don't eat me” signal. CD47 binds to SIRP-alpha on the surface of macrophages and disables their phagocytic function. Previous data showed CD47 blockade enhanced phagocytosis of tumor cells in vitro and improved survival of mice transplanted with human tumors. However, CD47 blockade has yet to be examined in a fully syngeneic system where the potential for tumor phagocytosis by macrophages and/or dendritic cells to promote presentation of tumor antigens to T cells can be defined. It has been reported that CD47 blockade can hinder T cell activation; however, this also has not been examined in a syngeneic system. Our hypothesis was that inducing tumor cell phagocytosis by CD47 blockade would enhance T-cell-mediated anti-tumor responses. Our data show that CD47 was expressed on the EL4 thymoma and B16-F10 melanoma cell lines that are syngeneic to H-2b, as well as on their ovalbumin-expressing derivatives EG7 and B16-OVA. CD47 also was expressed on CD8+ T cells and was further upregulated upon stimulation, suggesting it might play a role in immune effector function. However, in our hands CD47 blockade using antibody MIAP-301 did not inhibit activation of CD8+ T cells in vitro, and in preliminary experiments, CD47 blockade appeared to enhance activation of antigen-specific CD8+ T cells in vivo. Ongoing work is evaluating the effects of CD47 blockade and phagocytosis on antigen presentation in vitro and the effects of CD47 blockade on the generation of tumor-specific CD4 and CD8 T cells in vivo. We also plan to confirm that T cells activated under conditions of CD47 blockade can recognize endogenous tumor antigens to which there may be self-tolerance. Supported by an HHMI Medical Student Fellowship (to KA), by the GREYlong Foundation, and by grant P01 AI035296 (to MFM). Citation Format: Katie L. Anderson, Daisuke Ito, Debra C. Lins, Julie M. Curtsinger, Matthew F. Mescher, Jaime F. Modiano. CD47 blockade to enhance adaptive anti-tumor immune responses. [abstract]. In: Proceedings of the 105th Annual Meeting of the American Association for Cancer Research; 2014 Apr 5-9; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2014;74(19 Suppl):Abstract nr 4082. doi:10.1158/1538-7445.AM2014-4082
Expression of RASGRF2 in non-small cell lung cancer and its effect of transfection on biological behavior of human NSCLC lines H1299
Authors: Xueshuang Gu, Hong Chen
Journal: European Respiratory Journal (2012)

For RASGRF2 participating in H-ras signaling pathway, it has been identified as one of potential tumor suppressor genes. There are few reports on whether RASGRF2 plays a role in the pathogenesis of NSCLC. Our study was designed to explore the expression of RASGRF2 in NSCLC, and its effectiveness on clinical and pathological features. Furthermore, the effectiveness of RASGRF2 on the biological characteristics of NSCLC lines H1299 was considered. The expression of RASGRF2 was detected by SP in cancerous tissues and adjacent non-neoplastic tissues of 48 patients with NSCLC. Of 18 cases, mRNA were detected by RT-PCR.H1299 were transfected with RASGRF2-GFP. The effectiveness of RASGRF2-GFP on mitotic cycle and apoptosis of stable expression ones were evaluated by Flow Cytometry, and its proliferation were examined by MTS.The loss expression of RASGRF2 in cancerous tissues was 54%,but it was 88% in normal tissues(P 0.05). The mitotic cycle of transfected H1299, which had stable expression of RASGRF2-GFP, were found blocked at S stage, but the apoptosis and proliferation had no significant changes. The inactivation of RASGRF2 is an initial issue in the pathogenesis of lung cancer. Detecting RASGRF2 will help make a definite diagnosis of lung cancer in some extent. RASGRF2 may suppress the development of carcinoma by interfering mitotic cycle.
Abstract 12802: Western Diet Impairs Cardiac Systolic and Diastolic Function in the Mouse
Authors: Salvatore Carbone, Stefano Toldo, Andrea Nordio, Carlo Marchetti, Eleonora Mezzaroma, Adolfo G Mauro, Jessica Regan, Chiara Sonnino, Fadi N Salloum, Benjamin W Van Tassell, Antonio Abbate
Journal: Circulation (2014)

Introduction: Western diet (WD), rich in saturated fat and sucrose, has pro-inflammatory properties and promotes cardiovascular disease. Whether WD has direct effects on cardiac function is unknown. Hypothesis: We hypothesized that WD would negatively affect cardiac systolic and diastolic function in the mouse. Methods: CD1 8 week-old male mice were fed with standard chow diet with 17% fat content (N=8) or WD with 42.0% fat content (N=11) for 8 weeks. Food intake was measured daily. Mice underwent transthoracic echocardiography under mild sedation with pentobarbital at baseline, 4 weeks and 8 weeks to measure left ventricular end-diastolic diameter (LVEDD), ejection fraction (LVEF), mass (LVM), myocardial performance index (MPI) and isovolumetric relaxation time (IVRT). Left ventricular catheterization through retrograde right carotid artery approach was performed with a Millar catheter to measure peak systolic pressure (LVPSP) and end-diastolic pressure (LVEDP). An additional group of female mice (N=13) ...
Abstract 959: FAS mutations induce therapeutic resistance in non-Hodgkin lymphomas
Authors: Nathalie Johnson, Denis Gaucher, Ryan Morin, Randy Gascoyne, Joseph Connors, Marco Marra, Jerry Pelletier, Hawley Rigsby, Koren Mann
Journal: Cancer Research (2014)

Abstract Lymphomas are common (1/30 Canadians), but responses to chemotherapy depend on the tumour biology. We sequenced &amp;gt; 300 lymphomas at diagnosis and at relapse, identified FAS as a possible tumour suppressor gene and found that mutant FAS is associated with therapeutic resistance. FAS is the death receptor that initiates the extrinsic apoptotic pathway once activated by FAS ligand (FASL). Our studies indicated that the most common FAS mutation is a dominant negative allele whose product inhibits FAS-mediated apoptosis. This allele induces resistance to doxorubicin in murine lymphoma cells transplanted into syngeneic immune competent C57BL/6 mice but, unexpectedly, the allele has no effect on chemosensitivity in cultured lymphoma lines in vitro. Because FAS signaling is initiated by FASL from neighboring cells, we asked whether chemotherapy induces FAS or FASL expression in immune cells, thereby activating apoptosis in vivo but not in vitro. Indeed, exposure to chemotherapy induced FAS in primary and malignant B cells and increased FASL in benign T cells. Thus, we hypothesize that chemotherapy may induce an anti-tumour immune response mediated by FAS-FASL interactions, and that FAS mutations cause therapeutic resistance by blocking the chemotherapy-induced immune response. We will extend this work by evaluating the role of the immune response in chemotherapy-induced lymphoma apoptosis and by identifying therapies that will target FAS mutant lymphomas. Citation Format: Nathalie Johnson, Denis Gaucher, Ryan Morin, Randy Gascoyne, Joseph Connors, Marco Marra, Jerry Pelletier, Hawley Rigsby, Koren Mann. FAS mutations induce therapeutic resistance in non-Hodgkin lymphomas. [abstract]. In: Proceedings of the 105th Annual Meeting of the American Association for Cancer Research; 2014 Apr 5-9; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2014;74(19 Suppl):Abstract nr 959. doi:10.1158/1538-7445.AM2014-959
ORTHOSTATIC HYPOTENSION IN THE PRESENCE OF HYPERTENSIVE CARDIOVASCULAR DISEASE
Authors: E J DRENICK
Journal: Annals of Internal Medicine (1957)

Case Reports1 July 1957ORTHOSTATIC HYPOTENSION IN THE PRESENCE OF HYPERTENSIVE CARDIOVASCULAR DISEASEERNST J. DRENICK, M.D.ERNST J. DRENICK, M.D.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-47-1-124 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptNumerous instances of orthostatic hypotension have been reported. However, severe hypertensive cardiovascular disease complicating postural hypotension has apparently not been observed. Death as the direct result of postural hypotension has been reported very infrequently, and only a few complete postmortem studies are on record.1, 2 In this case the death seemed to have been caused by the hypotension and an autopsy was performed.CASE REPORTA 61 year old Negro male was admitted to the Domiciliary of the Los Angeles Veterans Administration Center on January 30, 1951. His chief complaints were weakness, lightheadedness, dizziness and fainting spells of three years'...Bibliography1. BradburyEggleston SC: Postural hypotension, a report of three cases, Am. Heart J. 1: 73, 1925. CrossrefGoogle Scholar2. EllisHaynes LBF: Postural hypotension, with particular reference to its occurrence in disease of the central nervous system, Arch. Int. Med. 58: 773, 1936. CrossrefGoogle Scholar3. CrostFriedlander EAH: Orthostatic hypotension: report of a case refractory to vasoconstrictor drugs; with observations on use of desoxycorticosterone, 1-norepinephrine, ACTH and vasopressor potentiating substances, Ann. Int. Med. 36: 1343 (May) 1952. LinkGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Los Angeles, California*Received for publication March 5, 1956.From the Medical Service, Veterans Administration Hospital, Los Angeles, and the Department of Medicine, School of Medicine, University of California at Los Angeles.Requests for reprints should be addressed to Ernst J. Drenick, M.D., Veterans Administration Center, Wilshire and Sawtelle Boulevards, Los Angeles 25, California. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited bySUPINE HYPERTENSION, BLOOD PRESSURE VARIABILITY AND CIRCADIAN RHYTHM IN AUTONOMIC FAILURE: THE ROLE OF AMBULATORY INTRA-ARTERIAL MONITORINGCircadian variation of blood pressure in autonomic failure.Effects of propranolol in a case of orthostatic hypotension.Orthostatic hypotension syndromeHemodynamics of idiopathic orthostatic hypotension 1 July 1957Volume 47, Issue 1Page: 124-131KeywordsAutopsyCardiovascular diseasesDyspneaElectrocardiographyHospital medicineHypotensionInsulinMedical servicesSyncope ePublished: 1 December 2008 Issue Published: 1 July 1957 PDF downloadLoading ...
Abstract 4376: Puncture Site Outcome in Patients With Aortic Stenosis Treated With Percutaneous Aortic Valve Implantation
Authors: Jose Suarez de Lezo, Jose Segura, Manuel Pan, Miguel Romero, Javier Suarez de Lezo, Soledad Ojeda, Francisco Mazuelos, Djordje Pavlovic, Manuel Crespin, Mercedes Lafuente, Daniel Garcia
Journal: Circulation (2009)

INTRODUCTION: Transcatheter aortic valve implantation (TAVI) has been shown to be an effective treatment in elderly patients with aortic stenosis. Surgical or percutaneous vascular access, allows f...
Abstract 2848: Medication Knowledge And Assistance In Older Chronic Heart Failure Patients.
Authors: Robyn Gallagher, Judith Donoghue, Lynn Chenoweth, Jane Stein-Parbury
Journal: Circulation (2007)

Medication knowledge and assistance in older chronic heart failure (CHF) patients. Medication adherence is central to the optimal management of CHF. Little is known about older patients’ knowledge of their medications or the factors that contribute to this knowledge. Aim: To describe and identify the predictors of medication knowledge in older CHF patients. Method: Subjects ( n = 62) aged over 55 years with moderate heart failure (New York Heart Association Class II and III) who identified as self-managing were recruited from hospital or rehabilitation. Interviews occurred at home four weeks post-discharge using a medication checklist and the Self-Efficacy in Chronic Illness Scale (Lorig et al, 2001). Multiple regression analysis determined the predictors of medication knowledge. Results: Patients were aged mean 78.4 years (sd 8.54 years), mostly male (57%) and had an average 8 (median, range 3–22) medications to take daily, of which 6 (median, range 3–14) were for CHF. Most managed their own medications (54%) but more than a quarter (28%) were assisted by reminding, dispensing and supervision. Compliance with medications was high (84%), although only half (53%) knew the name, main purpose and side effect of their medications. Patients with better self-efficacy (β = 2.88) and no help with medication (β = -21.05) had better medication knowledge (model F = 13.6, p = .000, R = .61, r 2 = .37). Conclusion: Older CHF patients have poor knowledge of their medications, which may be improved by promoting overall self-efficacy for disease management. Less knowledgeable patients received appropriate assistance with medications, but the consequence may be less knowledge and thus warrants further investigation.
AN UNUSUAL CASE OF AORTIC ANEURYSM
Authors: S. P. Sanford
Journal: Annals of Internal Medicine (1945)

Case Reports1 April 1945AN UNUSUAL CASE OF AORTIC ANEURYSMS. P. SANFORD, M.D.S. P. SANFORD, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-22-4-599 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptOn October 13, 1939, a negro male, age 18, who gave the date of his birth as June 3, 1921, was admitted to the hospital with primary syphilis. His history revealed that his father, age 45, was living and well, and that his mother died at the age of 30, cause unknown. Four siblings are living and well. The patient was single. He had had measles in childhood, mumps at eight, chickenpox at 10, and malarial fever at 13.His present illness had begun about three weeks before admission with a penile ulcer and generalized pustular eruption over the body....Bibliography1. BOYD LJ: A study of 4,000 reported cases of aneurysm of the thoracic aorta, Am. Jr. Med. Sci., 1924, clxviii, 654. CrossrefGoogle Scholar2. EVANS B: Syphilitic thoracic aneurysm in young adults, Brit. Med. Jr., 1941, i, 851. CrossrefGoogle Scholar3. SANFORD SP: Statistical study of seventy-one cases, Ann. Int. Med., 1931, iv, 1417. LinkGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Savannah, Georgia*Received for publication July 26, 1943.From the Medical Service, U. S. Marine Hospital, Savannah, Georgia. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byKrankheiten der GefäßeKrankheiten der GefäßeAneurysmenAneurysmen 1 April 1945Volume 22, Issue 4Page: 599-601KeywordsAneurysmsArmed forcesBirthChickenpoxFeversMeaslesMedical servicesMumpsSyphilisUlcers ePublished: 1 December 2008 Issue Published: 1 April 1945 PDF downloadLoading ...