SOFT TISSUE CALCIFICATION, WITH SPECIAL REFERENCE TO ITS OCCURRENCE IN THE "COLLAGEN DISEASES"
Authors: C E WHEELER, A C CURTIS, E P CAWLEY, R H GREKIN, B ZHEUTLIN
Journal: Annals of Internal Medicine (1952)

Article1 April 1952SOFT TISSUE CALCIFICATION, WITH SPECIAL REFERENCE TO ITS OCCURRENCE IN THE "COLLAGEN DISEASES"CLAYTON E. WHEELER, ARTHUR C. CURTIS, F.A.C.P., EDWARD P. CAWLEY, ROBERT H. GREKIN, BERTRAM ZHEUTLINCLAYTON E. WHEELERSearch for more papers by this author, ARTHUR C. CURTIS, F.A.C.P.Search for more papers by this author, EDWARD P. CAWLEYSearch for more papers by this author, ROBERT H. GREKINSearch for more papers by this author, BERTRAM ZHEUTLINSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-36-4-1050 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptINTRODUCTIONCalcification is a process which results in the accumulation of lime salts in a tissue in amounts which are demonstrable on microscopic, roentgenographic and often on naked-eye examination. Normally this process involves only bones and teeth, and when any other tissue is the site of calcium deposition, pathologic calcification, or calcinosis, is said to exist. Although there has been much investigation of this subject, the exact mechanism is not known whereby demonstrable aggregates of the carbonate and phosphate of calcium are produced from invisible components present in blood and tissue fluid.Normally the amount of calcium and phosphorus in...Bibliography1. AlbrightReifenstein FEC: The parathyroid glands and metabolic bone disease, 1948, Williams and Wilkins Co., Baltimore. Google Scholar2. AtkinsonWeber FRFP: Cutaneous and subcutaneous calcinosis, Brit. J. Dermat. 50: 267, 1938. CrossrefGoogle Scholar3. Barr DP: Pathological calcification, Physiol. Rev. 12: 593, 1932. CrossrefGoogle Scholar4. BauerMarbleBennett WAG: Further studies in a case of calcification of subcutaneous tissue in a child (calcinosis universalis), Am. J. M. Sc. 182: 237, 1931. 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Author, Article, and Disclosure InformationAffiliations: *Received for publication August 13, 1951.From the Department of Dermatology and Syphilology, University of Michigan Medical School, Ann Arbor, Michigan. (Dr. Wheeler and Dr. Cawley are now at the University of Virginia.) 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