VENTRICULAR FIBRILLATION IN ACUTE CORONARY ARTERY THROMBOSIS DURING THE INTRAVENOUS ADMINISTRATION OF QUINIDINE SULPHATE; REPORT OF A FATAL CASE
Authors: Harold L. Rakov
Journal: Annals of Internal Medicine (1942)

Case Reports1 March 1942VENTRICULAR FIBRILLATION IN ACUTE CORONARY ARTERY THROMBOSIS DURING THE INTRAVENOUS ADMINISTRATION OF QUINIDINE SULPHATE; REPORT OF A FATAL CASEHAROLD L. RAKOV, M.D.HAROLD L. RAKOV, M.D.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-16-3-571 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptIntroductionThe ectopic rhythms which occur following an acute myocardial infarction are usually transitory and benign. Sometimes ventricular tachycardia is an exception to this rule. This arrhythmia has been produced experimentally by ligation of the coronary arteries, and Levine1observed it frequently in acute myocardial infarction. Master,2on the other hand, found that it occurred in coronary occlusion infrequently except following the use of digitalis. The ischemic area is hyperirritable and a source of this idioventricular rhythm. Epinephrine enhances this irritability not only by increasing the myocardial ischemia at a time when a greater blood supply is needed,3but also...References1. LEVINEFULTON SAMH: Effect of quinidine sulphate on ventricular tachycardia—clinical observations, Jr. Am. Med. Assoc., 1929, xvii, 1162. CrossrefGoogle Scholar2. MASTERDACKJAFFE AMSHL: Partial and complete heart block, Am. Jr. Med. Sci., 1938, cxcvi, 513. CrossrefGoogle Scholar3. MILLESSMITH GPW: Effects of epinephrin on the heart, Am. Heart Jr., 1937, xiv, 198. CrossrefGoogle Scholar4. WIGGERS CJ: The mechanism and nature of ventricular fibrillation, Am. Heart Jr., 1940, xx, 399. CrossrefGoogle Scholar5. SMITHMCEACHERNHALL FHCGGE: The effect of the intravenous administration of quinidine sulphate on the development of ventricular fibrillation following sudden occlusion of the circumflex branch of the left coronary artery—an experimental study, Am. Heart Jr., 1940, xx, 620. CrossrefGoogle Scholar6. HEPBURNRYKERT JHE: Use of quinidine sulphate intravenously in ventricular tachycardia, Am. Heart Jr., 1937, xiv, 620. CrossrefGoogle Scholar7. SCHWARTZJEZER SBA: The action of quinine and quinidine on patients with transient ventricular fibrillation, Am. Heart Jr., 1934, ix, 792. CrossrefGoogle Scholar8. DAVISSPRAGUE DHB: Ventricular fibrillation—its relation to heart block, report of a case in which syncopal attacks and death occurred in the course of quinidine therapy, Am. Heart Jr., 1929, iv, 559. CrossrefGoogle Scholar9. GORDONMATTONLEVINE BMSA: The mechanism of death from quinidine and a method of resuscitation; an experimental study, Jr. Clin. Invest., 1925, i, 497. CrossrefGoogle Scholar10. SMITHBOLAND HLEW: Treatment of auricular fibrillation with quinidine and strychnine, Jr. Am. Med. Assoc., 1939, cxiii, 1017. CrossrefGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Kingston, New York*Received for publication January 7, 1941. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byQuinidine Sulfate (2:1) (Salt) 50-54-4Prospective comparison of intravenous quinidine and intravenous procainamide in patients undergoing electrophysiologic testingCardiac ArrhythmiasIntravenous quinidine by intermittent bolus for electrophysiologic studies in patients with ventricular tachycardiaProarrhythmic effects of the new antiarrhythmic agent flecainide acetateSafety and efficacy of intravenous quinidineA reevaluation of intravenous quinidineQuinidine SyncopeThe treatment of quinidine-induced ventricular fibrillation by closed-chest resuscitation and external defibrillationDie Rhythmusstörungen des Herzens (einschließlich der intramuralen Leitungsstörungen und des Alternans)Ventricular fibrillation during and after coronary artery occlusionExperimental Coronary Artery Occlusion: Ventricular Fibrillation and Survival as Affected by Selected Drugs and Ionic AlterationsAdams-Stokes syndromeDEPRESSION OF THE HEART BY QUINIDINE AND ITS TREATMENTVentricular standstill during the intravenous procaine amide treatment of ventricular tachycardiaParoxysmal ventricular tachycardia and fibrillation due to quinidine 1 March 1942Volume 16, Issue 3Page: 571-576KeywordsAcute myocardial infarctionArrhythmiaBloodCoronary arteriesEpinephrineIschemiaLigation assayThrombosisVentricular fibrillationVentricular tachycardia ePublished: 1 December 2008 Issue Published: 1 March 1942 PDF downloadLoading ...