tbuckley/cabot-search huggingface dataset:
Abstract 3629: Socioeconomic and Ethnic Disparities in the Use of Biventricular Pacemakers in Heart Failure Patients with Left Ventricular Systolic Dysfunction
Authors: John C Casale, Flossie Wolf, Yanfen Pei, Richard B Devereux
Journal: Circulation (2007)

Background : Biventricular pacing (BiV) is an important therapeutic advance for symptomatic heart failure (HF) patients (pts) with reduced left ventricular ejection fraction (EF), but whether socioeconomic and ethnic disparities exist in the use of BiV in HF pts is unknown. Methods : Data were collected on all hospitalized HF pts with an EF ≤ 35% from Pennsylvania hospitals that implanted BiVs from Jan. 2004 to Dec. 2005. These hospitals submitted clinical data from chart abstraction and administrative data to the Pennsylvania Health Care Cost Containment Council. Multiple logistic regression analyses used patient clinical data, insurance and hospital characteristics to identify independent predictors of BiV implantation in symptomatic HF pts with EF≤ 35%. Results : Of the 20,269 HF pts with EF≤ 35%, BiV was implanted in 2,065/15,861 (13%) whites, 182/3107 (5.9%) African-Americans and 175/1301 (13.5%) others. Analysis of 12 clinical variables identified associations of older age, male gender and prior myocardial infarction or bypass surgery with a higher likelihood of BiV implantation (all p&lt;.0001). Pts with diabetes or higher Mediqual Atlas severity score were less likely to have BiV implantation (both p&lt;.01). Pts with lower EF or with intraventricular conduction delay were more likely to have BiV implantation (both p&lt;.0001). After adjusting for these variables, African-American ethnicity (odds ratio (OR) 0.50, [95% confidence interval (CI) 0.42– 0.60], p&lt;.0001) and poverty level (defined as the percentage of residents in a zip code whose household income was below the federal poverty threshold) comparing the poorest quintile to the other quintiles (OR 0.79, [95% CI 0.70 – 0.89], p&lt;.0001), were independently associated with lower likelihood of BiV implantation. Additional independent predictors of a higher likelihood of BiV implantation included commercial and Medicare vs. Medicaid, self-pay or other insurance type, and for-profit hospital status (both p&lt;.05). Conclusion : In a large statewide sample, BiV was implanted less frequently in African-Americans and in lower income pts, independent of clinical, hospital and insurance characteristics, identifying persisting disparities in use of advanced cardiac technology.
Abstract 12007: Prophylactic Catheter Ablation Before Cardioverter Defibrillator Implantation Can Prolong the Time to First Shock Therapy and Electrical Storm in Patients with Sustained Ventricular Tachycardia and Non-Ischemic Cardiomyopathy
Authors: Atsushi Suzuki, Akihiro Yoshida, Asumi Takei, Mitsuaki Ito, Kimitake Imamura, Ryudo Fujiwara, Tomoyuki Nakanishi, Soichiro Yamashita, Ken-ichi Hirata, Akira Shimane, Katsunori Okajima
Journal: Circulation (2011)

Background: Prophylactic ventricular tachycardia (VT) ablation before cardioverter defibrillator implantation in patients with stable VT and ischemic cardiomyopathy (ICM) prolongs time to recurrenc...
Abstract 20492: Prognostic Significance of Minor Troponin I Elevations on 1-Year Mortality Among Patients Discharged from the Emergency Department: Results from the Troponin I in the Emergency Room (TiER) Study.
Authors: Saman Fakheri, Vicken J Aharonian, Prakash Mansukhani, Michael Jorgensen, Albert Y Shen, Steven Khan, Nigel Gupta, Colin Watanabe, Naing Moore, Richard Contreras, Somjot S Brar
Journal: Circulation (2010)

Background: The prognostic significance of minor troponin I elevations on 1-year mortality among patients evaluated and discharged from the emergency department (ED) remains uncertain. Methods: Con...
Medical perspective on nuclear power. Council on Scientific Affairs
Authors: T.C. Doege, W.R. Hendee
Journal: JAMA (1989)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Bosutinib As Therapy For Chronic Phase Chronic Myeloid Leukemia Following Failure With Imatinib Plus Dasatinib and/Or Nilotinib: 36-Month Update
Authors: Jorge E. Cortes, H. Jean Khoury, Hagop M. Kantarjian, Jeff H. Lipton, Dong-Wook Kim, Maureen G. Conlan, Eric Leip, Kathleen Turnbull, Tim H. Brümmendorf, Carlo Gambacorti-Passerini
Journal: Blood (2013)
Abstract 13623: Moderate to Severe Acute Kidney Injury During Heart Failure Treatment is a Long-Term Predictor of Sudden Cardiac Death in Patients Discharged From Acute Heart Failure
Authors: Takahisa Yamada, Takashi Morita, Yoshio Furukawa, Koji Tanaka, Yusuke Iwasaki, Masato Kawasaki, Yuki Kuramoto, Takashi Naito, Tadao Fujimoto, Kentaro Ozu, Takumi Kondou, Kaoruko Sengoku, Hironori Yamamoto, Masatake Fukunami
Journal: Circulation (2011)
Abstract 17118: Isolated Diastolic Hypotension Without Systolic Hypotension or Hypertension is an Independent Risk Factor for Incident Heart Failure Among Community-Dwelling Older Adults
Authors: Jason L Guichard, Yan Zhang, Carl J Pepine, Inmaculada B Aban, Thomas E Love, David A Calhoun, Wilbert S Aronow, Prakash C Deedwania, Ali Ahmed
Journal: Circulation (2011)

Background: We have previously demonstrated that isolated diastolic hypotension (IDH), as defined by diastolic blood pressure (DBP) &lt;60 mm Hg with systolic blood pressure (SBP) &gt;100 mm Hg, is a significant independent risk factor for incident heart failure (HF) in older adults with and without hypertension ( 2010 ACC Abstract 1241-109 ). However, confounding by systolic hypertension was a concern and whether this association would persist in those without hypertension remained unclear. Methods: Of the 5795 community-dwelling older adults, age ≥65 years, in the public-use copy of the Cardiovascular Health Study data obtained from the National Heart, Lung and Blood Institute, 3298 had SBP between 100 and 139 mm Hg, of whom 594 (19%) had IDH (DBP &lt;60 mm Hg). Propensity scores for IDH, calculated for each of the 3298 participants, were used to assemble a matched cohort of 548 pairs of individuals with and without IDH who were balanced on 40 baseline characteristics. Results: Matched participants had a mean (±SD) age of 73 (±5) years, 62% were women, and 7% were African American. Matched participants with and without IDH had a mean SBP of 120.0 and 120.3 mm Hg respectively (p=0.618). Centrally-adjudicated incident HF occurred in 23% and 16% of matched participants with and without IDH respectively (matched HR, 1.47; 95% CI, 1.12-1.93; p=0.005; Figure ). IDH had no significant association with all-cause mortality among matched participants (matched HR, 1.18; 95% CI, 0.99-1.42; p=0.067). Conclusion: Among community dwelling older adults, isolated diastolic hypotension, in the absence of systolic hypotension or hypertension, was associated with a significant increased risk of new-onset HF but had no significant association with all-cause mortality.
Abstract 2019: Coronary Revascularization Strategy in British Columbia: Change in Ratio of PCI to CABG Between 2000 and 2007
Authors: Robert H Boone, May Lee, Min Gao, Christopher R Thompson, Bernice Budz, Karin H Humphries, for Cardiac Services Bc Registry Investigators
Journal: Circulation (2008)

Revascularization strategies for patients with CAD have varied widely and changed over time. We sought to evaluate the time trend of the PCI to CABG ratio in the province of British Columbia, Canad...
Abstract 20077: Relationship Between Serum 25-Hydroxyvitamin D and C- Reactive Protein:Findings From the Continuous National Health and Nutrition Examination Survey 2001-2006.
Authors: Muhammad Amer, Rehan Qayyum
Journal: Circulation (2010)

Objective: Relationship between vitamin D deficiency and increased systemic inflammation is not settled.To study this relationship in adult US population, we examined the association between serum ...
A SURVEY OF RECENT DEVELOPMENTS CONCERNING THE CONCEPTS OF CORONARY DISEASE AND ITS MANAGEMENT
Authors: L N KATZ
Journal: Annals of Internal Medicine (1947)

Article1 November 1947A SURVEY OF RECENT DEVELOPMENTS CONCERNING THE CONCEPTS OF CORONARY DISEASE AND ITS MANAGEMENTLOUIS N. KATZ, M.D., F.A.C.P.LOUIS N. KATZ, M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-27-5-705 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptCoronary disease is one of the most important diseases afflicting mankind. As the medical profession has reduced infantile mortality, improved sanitation, developed antibiotics and learned to deal with epidemic diseases, there has been a constant shift towards an increase in the frequency of degenerative diseases, like hypertension, arteriosclerosis, cancer, and their sequelae. Arteriosclerosis is thus becoming an ever growing problem and it will continue to grow in importance as the population becomes older. Arteriosclerosis is not a matter of aging, though it is more common in the elderly. It is a disease which affects not only old people, but also... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Chicago, Illinois*Morning Lecture, Twenty-Eighth Annual Session, American College of Physicians, Chicago, May 1, 1947.From the Cardiovascular Department, Michael Reese Hospital, Chicago. This department is supported in part by the Michael Reese Research Foundation. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byChanges in bradykinin level in coronary sinus blood after the experimental occlusion of a coronary arteryTHE DESIGN OF PROPER EXPERIMENTS TO INVESTIGATE CLINICAL ANGINA PECTORIS AND THE IMPORTANCE OF KNOWING THE DETERMINANTS OF CORONARY FLOW IN CONSIDERING THERAPY OF ANGINA PECTORISPriscoline in the therapy of dysmenorrheaTransfusion Treatment of Shock Due to Myocardial InfarctionCervical Vagus—Sympathetic Block in Pulmonary EmbolismCardiac painThe dynamics of muscle tonus and its relationship to circulatory failure Part III 1 November 1947Volume 27, Issue 5Page: 705-722KeywordsAgingAntibioticsElderlyHypertensionMortalitySanitation ePublished: 1 December 2008 Issue Published: 1 November 1947 PDF downloadLoading ...
Abstract 83: Sudden ETCO2 Trend Change Alerts During Out-of-Hospital Cardiopulmonary Resuscitation Using an Automated Capnogram Analysis Algorithm
Authors: Mohamud Daya, Eric Helfenbein, Ahamed Idris, Dana Edelson, Reza Firoozabadi, Saeed Babaeizadeh, Sophia Zhou
Journal: Circulation (2011)

Background Capnography has recently become the standard-of-care for EMS personnel during out-of-hospital resuscitation to confirm tracheal tube (TT) placement and monitor quality of CPR. Although t...
727. Baculovirus GP64 Pseudotyped Lentiviral Vectors for Improved Hepatocyte Transduction
Authors: Toshio Naka, Tsuyoshi Sakoda, Yoshio Fujioka, Takeshi Tsujino, Mitsumasa Ohyanagi
Journal: Molecular Therapy (2004)

(Background) Retrovirus based vectors integrate the transgene into the genome of the target cells, which can sustain long-term expression. However, the transduction efficiency has been known to be low. Ultrasound was reported to increase gene expression using plasmid DNA. However, there are no reports which show ultrasound effect to virus-mediated gene transfer efficiency. (Methods) Retroviral mediated gene transfer system was used to transfect cultured 293T cells, bovine aortic endothelial cells (BAECs), rat aortic smooth muscle cells (RASMCs), and rat skeletal muscle myoblasts (L6 cells) with the LacZ gene combined with ultrasound exposure. Skeletal muscle is thought to be easy and favorable protein producing organ by gene transfer. We also investigated the efficiency of retroviral-mediated gene transfer into regenerating skeletal muscle in vivo. (Results) Below 1.0 watts/cm2 and 5 seconds exposure, ultrasound showed no cytotoxicity to 293T cells transduced by retrovirus, and no toxicity to virus itself. At the same condition, ultrasound resulted in significant increases in retrovirus-mediated gene expression at 6.6-fold, 4.8-fold, 2.3-fold, and 3.2-fold in 293T cells, BAECs, RASMCs, and L6 cells respectively. Ultrasound enhanced in vivo retroviral-mediated LacZ gene transfer by direct injection into hind limb skeletal muscle compared with retrovirus only. (Conclusions) Ultrasound-associated local gene therapy has potential for not only plasmid-DNA-, but also viral-mediated gene transfer in vivo and in vitro.
Final height of patients who underwent bone marrow transplantation for hematological disorders during childhood: a study by the Working Party for Late Effects-EBMT.
Authors: Amnon Cohen, Attilio Rovelli, Boudewijn Bakker, Cornelio Uderzo, Maria Teresa Van Lint, Helene Esperou, Alberto Gaiero, Alison D. Leiper, Roland Dopfer, Jean Yves Cahn, Franco Merlo, Hans J. Kolb, Gerard Socié
Journal: Blood (1999)
Splenectomy in a General Hospital
Authors: J M Glass, J M Gilbert
Journal: Journal of the Royal Society of Medicine (1996)

Splenectomy is often performed in patients with malignant disease or trauma who are at a high risk of complications. In the long term, it increases the risk of infection by encapsulated bacteria. An audit was performed to determine the reasons for splenectomy in a district general hospital, to review the results and complications of surgery, and to see how often the patients were prescribed antibacterial prophylaxis. Twenty-eight patients underwent splenectomy in 3 years. The indication was haematological disease in 13 and trauma in four. In the remaining nine the spleen was removed either as part of a radical gastrectomy or during some other abdominal procedure. Six of the 28 patients had died, one within 30 days from disseminated intravascular coagulopathy following an emergency gastrectomy and splenectomy for haematemesis, two from progressive haematological malignant disease, two from non-haematological malignancy, and one from bronchopneumonia. Of the nine patients (32%) with complications, three required a further laparotomy. Most patients had been prescribed pneumococcal vaccine (85%) and prophylactic antibiotics (93%).
When doctors might kill their patients
Authors: R. Twycross, C. R Morris, G T Freshwater, A C McKay
Journal: BMJ (1999)

Editor—Gillon’s editorial arising from the trial of Dr David Moor showed clear (and therefore forceful) analytical logic,1 but I found Doyal’s contribution on the same topic was disturbing because it partly missed the point.2 Broadly speaking, the principle of double effect states that if measures taken to relieve physical or mental suffering cause the death of a patient it is morally and legally acceptable provided the doctor’s intention is to relieve the distress and not to kill the patient. This is a universal principle without which the practice of medicine would be impossible. It follows inevitably from the fact that all treatment has inherent risks.

Discussions of the principle of double effect tend to focus on the care of terminally ill patients and the use of morphine to relieve pain. Regrettably, this gives the false impression that the use of morphine in this circumstance is a high risk strategy. When correctly used, morphine and other strong opioids are safe–safer than non-steroidal anti-inflammatory drugs, which are prescribed with impunity. The use of both classes of analgesic is justified on the basis that the benefits of pain relief far outweigh the risk of serious adverse effects. Indeed, clinical experience suggests that patients with cancer whose pain is relieved live longer than would have been the case if they had continued to be exhausted and demoralised by unremitting severe pain.

Most people accept that a greater risk is acceptable in more extreme circumstances. It is axiomatic, however, that effective measures that carry the least risk to life will be used. Thus although it may occasionally be necessary (and acceptable) to render a patient unconscious, it remains unacceptable (and unnecessary) to cause death deliberately.

In some quarters it is repeatedly stated that the principle of double effect is hypocritical and a smokescreen for euthanasia. Such views stem from failure to appreciate that double effect is a universal principle and the false belief that morphine usually shortens the life of a dying patient. Misleading statements that stem from such misunderstandings include “hospice doctors often kill their patients,” when in practice specialist palliative care services are effectively a “euthanasia-free zone.”3

Limiting “helping patients to die peacefully” to physician assisted suicide and euthanasia is misleading; this is the essential task of all who work in palliative care. Even at the end of life the aim of treatment must remain the relief of suffering and not the patient’s intentional death.

In making decisions, health professionals balance the benefits of the treatment against its foreseen burdens and risks. They will seek to find the right balance between maleficence and beneficence and thereby integrate our dual responsibility both to preserve life and to relieve suffering. In this way, Doyal’s either/or becomes both/and–both the best interests of patients and the moral character of clinicians.
Abstract 1930: Impact of Location of Geographical Miss on 1-year Outcomes after Sirolimus-eluting Stent Implantation: Insights from The STLLR Trial
Authors: Nobuaki Suzuki, Dominick J Angiolillo, Mark Tannenbaum, Alan Niederman, Mitchell Driesman, Alan Chu, John Patterson, Marco Pilla, Ren Kawaguchi, Yoshie Suzuki, Theodore A Bass, Marco A Costa
Journal: Circulation (2007)
Highly Sensitive Chemiluminescent Method for the Detection of Maternal Cell Contamination in Human Cord Blood Stored for Allotransplantation: The Experience of the Milano Cord Blood Bank
Authors: Francesca Poli, Loretta Crespiatico, Lucilla Lecchi, Girolamo Sirchia, Mario Scalamogna, Silvia Maria Sirchia, Isabella Garagiola, Laura Pedranzini
Journal: Blood (1997)
Abstract 3335: Exercise Hemodynamics as a Decision Help for the Indication for Surgery in Asymptomatic Patients with Severe Echocardiographic Mitral Insufficiency
Authors: Helmut Gohlke, Christa Gohlke, Nikolaus Jander, Martin Allgeier, Klaus Peters, Wolfgang Zeh, Thomas Comberg, Franz-Josef Neumann
Journal: Circulation (2006)
Older Scots to get free, long term care
Authors: Bryan Christie
Journal: BMJ (2000)

The Scottish Executive is planning to fund a full package of long term care for elderly people in a move which will give older people in Scotland a better deal than their counterparts in England and Wales. It is expected to increase pressure on politicians at Westminster to introduce similar changes.

Scotland's newly elected first minister, Henry McLeish, has announced that the Executive is planning to implement in full a Royal Commission report on the care of elderly people which recommended that the state should pay all medical and personal care costs for older people. Such a move has already …
Abstract 64: Therapeutic Hypothermia Does Not Affect Tissue Oxygenation, Metabolism or Microvascular Reactivity in Peripheral Muscle
Authors: Brian Suffoletto, Jeffrey Kristan, Jon Rittenberger, Francis Guyette, David Hostler, Clifton Callaway
Journal: Circulation (2010)

Introduction: Therapeutic hypothermia (TH) is thought to benefit patients by down-regulating the metabolism of tissue. Dynamic Near-infrared Spectroscopy (NIRS) non-invasively measures changes in tissue hemoglobin oxygen saturation. We sought to determine the effects of TH on NIRS variables, hypothesizing that post-cardiac arrest patients undergoing TH would have higher muscle tissue oxygenation (mtO2) but lower muscle tissue oxygen metabolism (mtOM) and microvascular reactivity (mtMR) compared to post-TH period. Methods: This prospective, observational study included a convenience sample of 28 patients hospitalized in the ICU of a university hospital and treated with TH between 10/09 and 05/10. Thenar tissue oxygen saturations were measured using a tissue spectrometer. A vaso-occlusive test was performed by rapid inflation of pneumatic cuff for 3 minutes within the first 24 hours of post-arrest care and following re-warming with calculation of occlusion and reperfusion slopes (%/minute) for mtOM and mtMR...
Visual information-processing impairments in deficit and nondeficit schizophrenia
Authors: J R Bustillo, G Thaker, R W Buchanan, M Moran, B Kirkpatrick, W T Carpenter
Journal: American Journal of Psychiatry (1997)

Previous studies of covert visuospatial attention in schizophrenia suggest a subtle form of right hemispatial neglect in acutely ill patients but not in chronic, stable patients. Because of previous work documenting various visual information-processing abnormalities in deficit schizophrenia, the authors investigated whether the deficit/nondeficit categorization would help clarify the presence of visual attentional asymmetries in schizophrenia.Performance on a covert visuospatial attention task was examined in clinically stable outpatients with schizophrenia (17 in a deficit subgroup and 28 in a nondeficit subgroup) and 25 normal subjects. Peripheral cue and central cue versions of the covert visuospatial attention task, at 100-, 200-, and 800-msec intervals between cue and target, were administered a week apart.The nondeficit patients exhibited a significant and abnormal asymmetry, with slower reaction time to targets presented in the right visual field than in the left visual field. This right visual field disadvantage was found with both versions of the task, but only at the 100-msec cue-target interval. The deficit patients were slowest in overall reaction time but, similar to the normal subjects, showed no asymmetry.The results are consistent with slower visual information processing in the left compared to the right cerebral hemisphere in nondeficit schizophrenia. This finding cannot be accounted for by differences between the deficit and nondeficit subgroups in demographic characteristics, chronicity, or medication effects, nor is it secondary to generalized cognitive impairment.
Pathophysiology of HPA axis abnormalities in patients with major depression: an update
Authors: R G Kathol, R S Jaeckle, J F Lopez, W H Meller
Journal: American Journal of Psychiatry (1989)

Four hypotheses have been proposed to explain why nonsuppression on the dexamethasone suppression test occurs in patients with major depression. These include 1) increased metabolism of dexamethasone, 2) decreased sensitivity of pituitary glucocorticoid receptors to dexamethasone, 3) hyperresponsivity of the adrenal gland to ACTH stimulation, and 4) increased central drive of the pituitary from hypothalamic/limbic structures that overrides the action of the dexamethasone. A critical review of the literature suggests that the last hypothesis is most closely supported by the data. Despite this conclusion, factors other than depression may be involved in hypothalamic-pituitary-adrenal axis dysfunction.