tbuckley/cabot-search huggingface dataset:
Vision-threatening Complications of Surgery for Full-thickness Macular Holes
Authors: Alay S. Banker, William R. Freeman, Jung V. Kim, David Munguia, Stanley P. Azen, William R. Freeman, Alay S. Banker, Jung W. Kim, William R. Freeman, Stanley P. Azen, Mei-Ying Lai, Gary Abrams, Stanley P. Azen, Rabbi Wayne Dosick, Sandy T. Feldman, William R. Freeman, Renata Ochabski, Stuart L. Fine, Ian Bailey, Thomas Aaberg, Brian Berger, George W. Blankenship, Alexander J. Brucker, Serge de Bustros, Akitoshi Yoshida, William R. Freeman, Howard Gilbert, Dennis P. Han, Gregg Kokame, Brooks McCuen, Donald A. Frambach, Joseph Olk, Jack O. Sipperley, Van W. Teeters, William Wood
Journal: Ophthalmology (1997)
Attenuated Vasodilator Responses to K+ in Essential Hypertensive Men
Authors: Henry W. Overbeck, Randall S. Derifield, Motilal B. Pamnani, Tümay Sözen
Journal: Journal of Clinical Investigation (1974)

To study limb vascular responses to K(+) in man, paired intrabrachial arterial infusions of isosmolar NaCl (control) and isosmolar KCl (0.077, 0.154, and 0.307 meq K(+)/min) in isosmolar NaCl were made in 20 normotensive men and 20 men with essential hypertension of mild to moderate severity. Limb blood pressures were monitored, limb blood flow was measured by indicator-dilution, and limb vascular resistance was calculated as mm Hg/ml flow/min/100 cm(3) limb volume. Measured concentrations of K(+) in limb venous plasma during infusion of 0.307 meq K(+)/min ranged from 4.8 to 9.0 meq/liter. Changes in limb venous hematocrit, sodium, calcium, magnesium, and osmolality were similar during control and KCl infusions. The infusions did not significantly change systemic blood K(+) concentration or blood pressures. Compared to NaCl, KCl decreased limb resistance (P < 0.05) in both normotensives and hypertensives, in a dose-related manner. Resting limb vascular resistances (IR) in hypertensives were greater (P < 0.05) than those in normotensives. Despite a positive correlation (P < 0.05) between IR and magnitude of response to K(+), responses in hypertensives to K(+) were not greater than those in normotensives. Further, analysis of covariance indicated that responses to 0.307 meq K(+)/min in hypertensives as a group were, in fact, less (P = 0.02) than those in normotensives. These results indicate that the vasodilator response to K(+) may be attenuated in a significant proportion of essential hypertensive men, as it is in renal hypertensive animals. These abnormal responses to K(+) in hypertensives may indicate an underlying defect in vascular K(+) metabolism.
Gilbert’s syndrome and hyperbilirubinemia in protease inhibitor therapy – An extended haplotype of genetic variants increases risk in indinavir treatment
Authors: Tim O. Lankisch, Georg Behrens, Ursula Ehmer, Ulrike Möbius, Juergen Rockstroh, Michael Wehmeier, Sandra Kalthoff, Nicole Freiberg, Michael P. Manns, Reinhold E. Schmidt, Christian P. Strassburg
Journal: Journal of Hepatology (2009)
Casual Attendances at an Accident Department and a Health Centre
Authors: P. N. Dixon, A. F. Morris
Journal: BMJ (1971)

In six months patients from a defined population of 11,417 provided 826 casual attendances for minor conditions at a hospital accident department and 1,430 similar attendances at a health centre treatment room. Attendances at the accident department reached a peak during the early evening, and included relatively more males, more adults, more patients with injuries than with symptoms, and more residents from the area immediately adjoining the hospital. Care of most of the casual attenders with minor conditions at the health centre treatment room would require additional nursing staff and some reorganization of primary care to enable a doctor to be available at most times. Attendances at night and at week-ends were insufficient to justify a 24-hour service at the health centre.
Nonenzymatic glycation of fibronectin impairs adhesive and proliferative properties of human vascular smooth muscle cells
Authors: F. Cavalot, G. Anfossi, I. Russo, E. Mularoni, P. Massucco, L. Mattiello, S. Burzacca, A.W.A. Hahn, M. Trovati
Journal: Metabolism (1996)
Clinical Hypertension and Its Interaction With Diabetes Among American Indians and Alaska Natives: Estimated rates from ambulatory care data
Authors: Brenda A Broussard, Sarah E Valway, Stephen Kaufman, Shelli Beaver, Dorothy Gohdes
Journal: Diabetes Care (1993)

OBJECTIVE— To estimate the prevalence of clinical hypertension and describe the coexistence with diabetes in American Indian and Alaska Native communities. RESEARCH DESIGN AND METHODS— A cross-sectional study of outpatient visits for hypertension and diabetes over a 1-yr period (1 October 1986 to 30 September 1987) in IHS facilities was conducted. RESULTS— The 1987 estimated age-adjusted prevalence of diagnosed hypertension for this group was 10.9/100 for people ≥15 yr of age. Thirty-seven percent of diabetic patients were diagnosed with hypertension. The relative risk of hypertension in the diabetic populations compared with the nondiabetic population varied from 4.7 to 7.7 among the different IHS areas. CONCLUSIONS— Despite high rates of diabetes and obesity, hypertension rates were relatively low among American Indians and Alaska Natives when compared with other ethnic groups in the U.S.
THE GENESIS OF SYMPATHETIC OPHTHALMITIS.
Authors: SAMUEL THEOBALD
Journal: JAMA (1905)

Thirty years ago, it is safe to say, there was but one view held as to the genesis of sympathetic ophthalmitis. The doctrine of Mackenzie that the optic nerve played the chief rôle in the transference of the inflammation from the exciting to the sympathizing eye, had been universally abandoned, and the view that the pathologic changes in the secondarily affected eye were the product of an influence—an influence of a reflex character—transmitted to it through the ciliary nerves, was as universally accepted. This view, which had been suggested by Mackenzie as an alternative but improbable explanation of the phenomena of sympathetic inflammation, and had been advanced previously by Tavignol, in 1845, was first brought prominently forward by Heinrich Müller, who published his conclusions—based on pathologico-anatomic observations—in 1858. His theory gained converts rapidly, and among those who accepted it, and who soon became its
Mitochondria-targeting drugs arsenic trioxide and lonidamine bypass the resistance of TPA-differentiated leukemic cells to apoptosis
Authors: Olivier Sordet, Cédric Rébé, Ingrid Leroy, Jean-Marie Bruey, Carmen Garrido, Carole Miguet, Gérard Lizard, Stéphanie Plenchette, Laurent Corcos, Eric Solary
Journal: Blood (2001)
Validation of a single-channel airflow monitor for screening of sleep-disordered breathing
Authors: H. Nakano, T. Tanigawa, Y. Ohnishi, H. Uemori, K. Senzaki, T. Furukawa, S. Nishima
Journal: European Respiratory Journal (2008)

A simple screening method for sleep-disordered breathing (SDB) is desirable for primary care practices. In the present study, a simple monitor, which utilises a new type of flow sensor and a novel algorithm, was prospectively validated. Home recording for 2 nights with the monitor only, followed by in-laboratory recording with the monitor together with polysomnography, were carried out in consecutive patients (n = 100) suspected of SDB. A subjective sleep log was also recorded. The signal was analysed using power spectral analysis, which yielded the flow respiratory disturbance index (flow-RDI). There was no recording failure at home. The reproducibility of the flow-RDI between the 2 nights at home was high (intraclass correlation coefficient = 0.92). The sensitivity and specificity of the in-laboratory flow-RDI to diagnose SDB were 0.96 and 0.82, 0.91 and 0.82, and 0.89 and 0.96, for apnoea/hypopnoea index (AHI) ≥5, ≥15 and ≥30 events·h −1 , respectively. The diagnostic ability in low-severity subgroups (female, normal weight, AHI &lt;15 events·h −1 ) was almost comparable to that in the entire group. Excluding subjective waking time on the sleep log from the recording time had no significant effect on the flow-RDI. The single-channel monitor is considered feasible for ambulatory sleep disordered breathing monitoring because of its easy applicability, high reproducibility and relatively high agreement with polysomnography results.
The extracellular matrix in hepatocellular carcinoma shows different localization patterns depending on the differentiation and the histological pattern of tumors: immunohistochemical analysis
Authors: Takuji Torimura, Takato Ueno, Sadataka Inuzuka, Motoaki Kin, Hiromasa Ohira, Yoshio Kimura, Yasuo Majima, Michio Sata, Hirohiko Abe, Kyuichi Tanikawa
Journal: Journal of Hepatology (1994)
Opioid dysregulation in anorexia nervosa: Naloxone effects on preprandial and postprandial growth hormone response to growth hormone-releasing hormone
Authors: L. De Marinis, A. Mancini, P. Zuppi, C. Fiumara, M.L. Fabrizi, L. Sammartano, G. Conte, D. Valle, S. Daini, F.M. Ferro
Journal: Metabolism (1994)
Idiopathic pyoderma gangrenosum and impaired lymphocyte function: failure of azathioprine and corticosteroid therapy
Authors: S.M. BREATHNACH, G.C. WELLS, H. VALDIMARSSON
Journal: British Journal of Dermatology (1981)

Journal Article Idiopathic pyoderma gangrenosum and impaired lymphocyte function: failure of azathioprine and corticosteroid therapy Get access S.M. BREATHNACH, S.M. BREATHNACH Department of Dermatology, St Thomas' Hospital, London SE1 7EH Search for other works by this author on: Oxford Academic Google Scholar G.C. WELLS, G.C. WELLS Department of Dermatology, St Thomas' Hospital, London SE1 7EH Search for other works by this author on: Oxford Academic Google Scholar H. VALDIMARSSON H. VALDIMARSSON Department of Immunology, St Mary's Hospital Medical School, Praed Street, London W1 1PG Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 104, Issue 5, 1 May 1981, Page 567, https://doi.org/10.1111/j.1365-2133.1981.tb08173.x Published: 01 May 1981 Article history Accepted: 04 July 1980 Published: 01 May 1981
Genome-wide association study of follicular lymphoma identifies a risk locus at 6p21.32
Authors: Lucia Conde, Eran Halperin, Nicholas K Akers, Kevin M Brown, Karin E Smedby, Nathaniel Rothman, Alexandra Nieters, Susan L Slager, Angela Brooks-Wilson, Luz Agana, Jacques Riby, Jianjun Liu, Hans-Olov Adami, Hatef Darabi, Henrik Hjalgrim, Hui-Qi Low, Keith Humphreys, Mads Melbye, Ellen T Chang, Bengt Glimelius, Wendy Cozen, Scott Davis, Patricia Hartge, Lindsay M Morton, Maryjean Schenk, Sophia S Wang, Bruce Armstrong, Anne Kricker, Sam Milliken, Mark P Purdue, Claire M Vajdic, Peter Boyle, Qing Lan, Shelia H Zahm, Yawei Zhang, Tongzhang Zheng, Nikolaus Becker, Yolanda Benavente, Paolo Boffetta, Paul Brennan, Katja Butterbach, Pierluigi Cocco, Lenka Foretova, Marc Maynadié, Silvia de Sanjosé, Anthony Staines, John J Spinelli, Sara J Achenbach, Timothy G Call, Nicola J Camp, Martha Glenn, Neil E Caporaso, James R Cerhan, Julie M Cunningham, Lynn R Goldin, Curtis A Hanson, Neil E Kay, Mark C Lanasa, Jose F Leis, Gerald E Marti, Kari G Rabe, Laura Z Rassenti, Logan G Spector, Sara S Strom, Celine M Vachon, J Brice Weinberg, Elizabeth A Holly, Stephen Chanock, Martyn T Smith, Paige M Bracci, Christine F Skibola
Journal: Nature Genetics (2010)
Macrophage Inflammatory Protein–1δ: A Novel Osteoclast Stimulating Factor Secreted by Renal Cell Carcinoma Bone Metastasis
Authors: Scott L. Kominsky, Samir M. Abdelmagid, Michele Doucet, Kelly Brady, Kristy L. Weber
Journal: Cancer Research (2008)

Abstract Approximately 30% of patients with renal cell carcinoma (RCC) develop bone metastasis, which is characterized by extensive osteolysis leading to severe bone pain and pathologic fracture. Although the mechanism of RCC-induced osteolysis is unknown, studies of bone metastasis have shown that tumor-induced changes in bone remodeling are likely mediated by alterations in the bone microenvironment. Here, we report the discovery of a novel osteoclast stimulatory factor secreted by RCC bone metastasis (RBM). Through microarray analysis, we found expression of the chemokine, macrophage inflammatory protein-1δ (MIP-1δ), to be increased in RBM versus patient-matched primary RCC tissues and confirmed this finding by quantitative reverse transcription-PCR (qRT-PCR) and ELISA (P &amp;lt; 0.05). Furthermore, MIP-1δ expression in RBM tissues was significantly (P &amp;lt; 0.001) higher than in human bone marrow, suggesting a potential alteration of the bone microenvironment. The receptors for MIP-1δ, CCR1 and CCR3, were expressed in both osteoclast precursors and mature, bone-resorbing osteoclasts as shown by qRT-PCR and Western analysis. In functional studies, MIP-1δ stimulated chemotaxis of two osteoclast precursor cell types: murine bone marrow mononuclear cells (BM-MNC) and RAW 264.7 cells. Furthermore, MIP-1δ treatment of murine calvaria caused increased bone resorption as determined by measurement of released calcium. Correspondingly, MIP-1δ significantly enhanced osteoclast formation and activity in response to RANKL in both BM-MNC and RAW 264.7 cells. Taken together, these data suggest that MIP-1δ expression is increased in RBM relative to RCC and bone marrow, and may promote RBM-induced osteolysis by stimulating the recruitment and differentiation of osteoclast precursors into mature osteoclasts. [Cancer Res 2008;68(5):1261–6]
A comprehensive functional characterization of BRCA2 variants associated with Fanconi anemia using mouse ES cell–based assay
Authors: Kajal Biswas, Ranabir Das, Blanche P. Alter, Sergey G. Kuznetsov, Stacey Stauffer, Susan L. North, Sandra Burkett, Lawrence C. Brody, Stefan Meyer, R. Andrew Byrd, Shyam K. Sharan
Journal: Blood (2011)
The Efficacy Versus Toxicity Profile of Combination Virotherapy and TLR Immunotherapy Highlights the Danger of Administering TLR Agonists to Oncolytic Virus-treated Mice
Authors: Diana M Rommelfanger, Marta C Grau, Rosa M Diaz, Elizabeth Ilett, Luis Alvarez-Vallina, Jill M Thompson, Timothy J Kottke, Alan Melcher, Richard G Vile
Journal: Molecular Therapy (2012)

Injection of oncolytic vesicular stomatitis virus (VSV) into established B16ova melanomas results in tumor regression, in large part by inducing innate immune reactivity against the viral infection, mediated by MyD88- and type III interferon (IFN)-, but not TLR-4-, signaling. We show here that intratumoral (IT) treatment with lipopolysaccharide (LPS), a TLR-4 agonist, significantly enhanced the local therapy induced by VSV by combining activation of different innate immune pathways. Therapy was further enhanced by co-recruiting a potent antitumor, adaptive T-cell response by using a VSV engineered to express the ovalbumin tumor-associated antigen ova, in combination with LPS. However, the combination of IT LPS with systemically delivered VSV resulted in rapid morbidity and mortality in the majority of mice. Decreasing the intravenous (IV) dose of VSV to levels at which toxicity was ameliorated did not enhance therapy compared with IT LPS alone. Toxicity of the systemic VSV + IT LPS regimen was associated with rapidly elevated levels of serum tumor necrosis factor-α (TNF-α) and interleukin (IL)-6, which neither systemic VSV, nor IT LPS, alone induced. These data show that therapy associated with direct IT injections of oncolytic viruses can be significantly enhanced by combination with agonists of innate immune activation pathways, which are not themselves activated by the virus alone. Importantly, they also highlight possible, unforeseen dangers of combination therapies in which an immunotherapy, even delivered locally at the tumor site, may systemically sensitize the patient to a cytokine shock-like response triggered by IV delivery of oncolytic virus.
DAIRY HYGIENE.WITH SPECIAL REFERENCE TO THE LIMITATION OF BOVINE TUBERCULOSIS.
Authors: RICHARD COLE NEWTON
Journal: JAMA (1905)

While perhaps it is impossible to be absolutely sure of the truth of any general statement, of which from its nature complete proof is unobtainable, we are justified, I think, in assuming that the statement that wild cattle are entirely free from tuberculosis is true. We are told that the native (Criollo) cattle of the Argentine are now and always have been free from tuberculosis. The appearance of the disease dates from the time when pure-blooded cattle were introduced into that country for breeding purposes. So it has been asserted that the native cattle of the Jura mountains and other places are, and always have been free from tuberculosis. So far as known, no animal running wild and eating the food that nature intended, has ever been tuberculous; and yet the disease is to-day the most common and most generally distributed of all diseases, affecting as it does
Increased C-11 Choline Uptake in Pagetic Bone in a Patient With Coexisting Skeletal Metastases From Prostate Cancer
Authors: Giampiero Giovacchini, Ana Maria Samanes Gajate, Cristina Messa, Ferruccio Fazio
Journal: Clinical Nuclear Medicine (2008)

Positron emission tomography/computed tomography (PET/CT) with C-11 choline is currently used for restaging prostate cancer in patients with biochemical failure. Skeletal Paget disease can be associated with prostate cancer, and bone scintigraphy can differentiate the 2 conditions. We report the case of a 74-year-old patient with prostate cancer who displayed multiple areas skeletal uptake of C-11 choline on a restaging PET/CT, which was attributed to both metastatic and pagetic bone diseases. The pattern of C-11 choline uptake was different between the 2 conditions, probably in relation to the different mechanisms of disease. The possibility of C-11 choline uptake in pagetic bone should be kept in mind when interpreting PET/CT findings in patients with prostate cancer.
ELECTROPHORETIC PATTERNS OF NORMAL AND PATHOLOGICAL HUMAN BLOOD SERUM AND PLASMA
Authors: Lewis G. Longsworth, Theodore Shedlovsky, Duncan A. MacInnes
Journal: The Journal of Experimental Medicine (1939)

The electrophoretic patterns of a series of normal and pathological human sera and plasmas have been obtained using the schlieren scanning method. From these patterns the mobilities and concentrations of the electrophoretically distinct protein components have been computed. The mobilities fall into five well defined groups corresponding to albumin, alpha, beta, and gamma globulins, and fibrinogen. The concentrations of the different components in pathological sera have been compared with those in normal sera, and the following tentative generalizations may be made. The albumin/globulin ratios for pathological sera have been consistently lower than those for normal sera. The values of the alpha globulin/albumin ratio for the sera of the febrile patients studied were high, the average value being over twice the normal value. The gamma globulin/albumin ratios for aplastic anemia and rheumatic fever sera were also above normal. Certain pathological conditions, notably nephrosis, were accompanied by large increases in a gamma globulin. There is evidence that, in part at least, this consists of a labile lipo-protein.
1058-67 Durability of bioprosthetic aortic valves: What is the re-operation risk for my patients?
Authors: John Puvimanasinghe, Johanna Takkenberg, Marinus Eijkemans, Ewout Steyerberg, Lex van Herwerden, Eric Jamieson, Gary Grunkemeier, Dik Habbema, Ad Bogers
Journal: Journal of the American College of Cardiology (2004)
Hospital Governing Boards
Authors: Alex S. Tulsky
Journal: JAMA (1982)

<h3>To the Editor.—</h3> I wish to reply to the timely and thoughtful article by Albert J. Miller, MD (1982;247:469). Any of us who have dealt with hospital governing boards assuredly share his views. In the simplistic era of yesteryear, it was appropriate for such boards to be composed of publicspirited citizens who thought it their duty to perform such functions as their community responsibility. Their "curricula vitae" accordingly could contain any number of such board appointments. I well remember the first staff physicians appointed to such a governing board some 25 years ago when the complexity of hospital operation first became evident. When, in recent years, provision of health care was further complicated by astronomic escalation of its cost and accordingly participated in by third-party payers, it was apparent that a radical change was necessary in hospital governance. Yesterday's trustee is as outmoded as the horse and buggy unless he
Control of blood pressure and risk of first acute myocardial infarction: Skaraborg hypertension project
Authors: U Lindblad, L Ramstam, L Ryden, J Ranstam, S-O Isacsson, G Berglund
Journal: BMJ (1994)

<h3>Abstract</h3> <b>Objective</b>: To analyse the relation between treated blood pressure and concomitant risk factor and morbidity from acute myocardial infarction. <b>Design</b>: Prospective longitudinal study. Treated blood pressures and other variables were used to predict acute myocardial infarction. <b>Setting</b>: Primary health care in Skaraborg, Sweden. <b>Subjects</b>: 1121 men and 1453 women aged 40-69 years at registration at outpatient clinics, 1977-81, with no evidence of previous myocardial infarction were followed up for an average of 7.4 years. Subjects were undergoing treatment with drugs to lower blood pressure or had blood pressure that exceeded the systolic or diastolic limits, or both, for diagnosis (&gt;170/&gt;105 mm Hg (patients aged 40-60 years) and &gt;180/&gt;110 mm Hg (older than 60 years)) on three different occasions, or both. <b>Main outcome measures</b>: First validated event of fatal or non-fatal acute myocardial infarction. Results - In men but not in women there was a negative relation between treated diastolic blood pressure and risk of acute myocardial infarction. Left ventricular hypertrophy and smoking were contributory risk factors in both sexes, as was serum cholesterol concentration in men. In men with normal electrocardiograms (n=345) risk increased with increasing diastolic blood pressure (P=0.047), whereas the opposite was found in men with electrocardiograms suggesting ischaemia or hypertrophy, or both (n=499, P=0.009). In those with a reading of 95-99 mm Hg the relative risk was 0.30 (P=0.034); at &gt;=100 mm Hg it was 0.37 (P=0.027). No similar relations were seen in women or for systolic blood pressure. <b>Conclusion</b>: It may be hazardous to lower diastolic20blood pressure below 95 mm Hg in hypertensive men with possible ischaemia or hypertrophy, or both. Electrocardiographic findings should be considered when treatment goals are decided for men with hypertension.
Germans face 8 a month rise in health insurance bills to pay for deficit
Authors: N. Stafford
Journal: BMJ (2010)

Plans by several German public health insurers to levy an additional monthly fee on members because of looming deficits have unleashed strong criticism from all sides, with social welfare organisations calling the fee unfair and politicians blaming each other while calling for renewed efforts to limit the rise of healthcare costs.

Germany’s largest public health insurer, DAK, with 6.4 million subscribers, and seven other public insurers announced on 25 January that they would levy an additional fee of €8 (£7; $11) a month. Members currently pay 14.9% of gross wages each month, with employers contributing 7%, into the federal public health fund, which funnels the money to public health insurers. The system, which covers more than 90% of the population, faces a deficit this year of up to €8bn.

Before a new healthcare reform …