TREATMENT OF VARIOUS INFECTIONS WITH PENICILLIN X, WITH A PRELIMINARY NOTE ON THE VALUE OF PENICILLIN X IN SCARLET FEVER
Authors: H L HIRSH, H F DOWLING, L K SWEET
Journal: Annals of Internal Medicine (1946)

Article1 July 1946TREATMENT OF VARIOUS INFECTIONS WITH PENICILLIN X, WITH A PRELIMINARY NOTE ON THE VALUE OF PENICILLIN X IN SCARLET FEVERHAROLD L. HIRSH, M.D., HARRY F. DOWLING, M.D., F.A.C.P., LEWIS K. SWEET, M.D.HAROLD L. HIRSH, M.D.Search for more papers by this author, HARRY F. DOWLING, M.D., F.A.C.P.Search for more papers by this author, LEWIS K. SWEET, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-25-1-78 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptPenicillin X is a fraction obtained from cultures of the same mold (Penicillium notatum) which produces penicillin G (or "regular" penicillin). It differs from penicillin G in the method by which it is extracted, and is usually found more abundantly in flask-grown penicillin. We have tested the relative sensitivity of various bacteria to penicillin X and penicillin G and have found that two to 16 times as much penicillin G is required as penicillin X, unit for unit, to kill many bacteria in vitro. The details of this study will be published elsewhere. Other investigators1-3have reported similar results. In...Bibliography1. WELCHPUTNAMRANDALLHERWICK HLEWARP: Penicillin X: Successful treatment of gonorrhea with a single intramuscular injection, Jr. Am. Med. Assoc., 1944, cxxvi, 1024. CrossrefGoogle Scholar2. ORYMEADSFINLAND EMMM: Penicillin X: Comparison with penicillin G with respect to sensitivity of pathogenic organisms and serum levels, Jr. Am. Med. Assoc., 1945, cxxix, 257. CrossrefGoogle Scholar3. LIBBYHOLMBERG RLNL: The activity of penicillin G and X in vitro, Science, 1945, cii, 303. CrossrefGoogle Scholar4. HIRSHDOWLING HLHF: Observations on the continuous intramuscular method of administering penicillin, Am. Jr. Med. Sci., 1945, ccx, 435. CrossrefGoogle Scholar5. WELCHPRICECHANDLER HCWVL: Prolonged blood concentrations after oral administration of modified penicillin, Jr. Am. Med. Assoc., 1945, cxxviii, 845. CrossrefGoogle Scholar6. SWEETLEPPER LKMH: Acute serous meningitis in scarlet fever, Jr. Pediat., 1944, xxiv, 295. CrossrefGoogle Scholar7. MEADSFLIPSEBARNESFINLAND MMEMWM: Penicillin treatment of scarlet fever, Jr. Am. Med. Assoc., 1945, ccxxiv, 785. CrossrefGoogle Scholar8. DOWLINGHIRSH HFHL: The inability of penicillin to inactivate streptococcus erythrogenic toxin. To be published. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Washington, D. C.*Received for publication November 26, 1945.From the George Washington Medical Division and the Pediatric and Infectious Disease Service, Gallinger Municipal Hospital, and the Department of Medicine and Pediatrics, George Washington University.†Supplied by Lederle Laboratories, Inc., Pearl River, New York. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byBibliography*A comparison of “symptomatic treatment,” gamma globulin, and penicillin in the treatment of scarlet feverA Comparative Study of Penicillins X and G and Crystalline Penicillin G 1 July 1946Volume 25, Issue 1Page: 78-87KeywordsBacteriaHospital medicineInfectious diseasesPenicillinRiversScarlet fever ePublished: 1 December 2008 Issue Published: 1 July 1946 PDF downloadLoading ...