Lemon-Yellow Nails and Long-Term Phenazopyridine Use
Authors: Guy Amit
Journal: Annals of Internal Medicine (1997)

Letters15 December 1997Lemon-Yellow Nails and Long-Term Phenazopyridine UseGuy Amit, MD and Amir Halkin, MDGuy Amit, MDHadassah Mount Scopus Hospital; 91240 Jerusalem, IsraelSearch for more papers by this author and Amir Halkin, MDHadassah Mount Scopus Hospital; 91240 Jerusalem, IsraelSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-127-12-199712150-00040 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:An 87-year-old man was referred to the hospital for dysuria. His medical history consisted of mild dementia and recurrent urinary tract infections. On examination, vital signs were normal and the patient did not seem to be in distress. His sclera were mildly icteric, and central cyanosis was observed. Deep lemon-yellow discoloration of all nails was also noted. Other than an enlarged prostate, findings on physical examination were unremarkable. Laboratory tests revealed macrocytic anemia (hemoglobin level, 11.9 g/dL; mean corpuscular volume, 99 fL), a bilirubin level of 104 µmol/L (mostly unconjugated), a lactate dehydrogenase level of 1063 U, ...References1. Thomas RJ, Doddabele S, Karnad AB. Chronic severe hemolytic anemia related to surreptitious phenazopyridine abuse [Letter]. Ann Intern Med. 1994; 121:308. Google Scholar2. Gabor EP. Chronic severe hemolytic anemia from phenazopyridine [Letter]. Ann Intern Med. 1995; 122:156. Google Scholar3. Nathan DM, Siegel AJ, Bunn HF. Acute methemoglobinemia and hemolytic anemia with phenazopyridine: possible relation to acute renal failure. Arch Intern Med. 1977; 137:1636-8. Google Scholar4. Gavish D, Knobler H, Gottehrer N, Israeli A, Kleinman Y. Methemoglobinemia, muscle damage and renal failure complicating phenazopyridine overdose. Isr J Med Sci. 1986; 22:45-7. Google Scholar5. Alano FA, Webster GD. Acute renal failure and pigmentation due to phenazopyridine (Pyridium). Ann Intern Med. 1970; 72:89-91. Google Scholar Author, Article, and Disclosure InformationAffiliations: Hadassah Mount Scopus Hospital; 91240 Jerusalem, Israel PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByDrug-induced Nail DisordersNail Reactions to Antibiotics, Antimalarials, and Other MedicationsPhenazopyridineCase report of chronic cough and legs edema of an 84-year-old man: When the solution is found in the nailsHighly selective differential pulse voltammetric determination of phenazopyridine using MgCr2O4 nanoparticles decorated MWCNTs-modified glassy carbon electrodeDrug-induced Nail ChangesSALICYLATES, PARACETAMOL, AND OTHER NON-OPIOID ANALGESICSPhenazopyridineAnti-inflammatory and antipyretic analgesics and drugs used in goutPhenazopyridine 15 December 1997Volume 127, Issue 12Page: 1137KeywordsBilirubinDrug therapyMean corpuscular volumeMethemoglobinMethemoglobinemiaRenal failureToxicityUrineVital signs Issue Published: 15 December 1997 CopyrightCopyright © 1997 by American College of Physicians. All Rights Reserved.PDF DownloadLoading ...