INSULIN-RESISTANT DIABETES MELLITUS ASSOCIATED WITH HEMOCHROMATOSIS
Authors: I B ESKIND, W FRANKLIN, F C LOWELL
Journal: Annals of Internal Medicine (1953)

Case Reports1 June 1953INSULIN-RESISTANT DIABETES MELLITUS ASSOCIATED WITH HEMOCHROMATOSISIRWIN B. ESKIND, M.D., WILLIAM FRANKLIN, M.D., FRANCIS C. LOWELL, M.D.IRWIN B. ESKIND, M.D.Search for more papers by this author, WILLIAM FRANKLIN, M.D.Search for more papers by this author, FRANCIS C. LOWELL, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-38-6-1295 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe amount of insulin required for the control of diabetes varies markedly. The insulin requirement is usually increased in the presence of infection, acidosis and coma, and often in association with endocrinopathies, liver disease, hemochromatosis and neoplasm. Furthermore, the insulin requirement of adolescent diabetics may be high and variable. Patients requiring over 200 units of insulin per day are generally considered as "insulin-resistant."1Some cases of insulin resistance have no associated condition to which the resistance can be attributed. The serum of such cases of "idiopathic" insulin resistance may neutralize insulin in a manner consistent with the presence of an...Bibliography1. Root HF: Insulin resistance and bronze diabetes, New England J. Med. 201: 201-206, 1929. CrossrefGoogle Scholar2. ThornForshamPruntyHills GWPHFTAG: A test for adrenal cortical insufficiency, J. A. M. A. 132: 1005-1009, 1948. CrossrefGoogle Scholar3. FranklinLowell WFC: On the preparation of human insulin for experimental use, J. Clin. Endocrinol. 9: 481-485, 1949. CrossrefGoogle Scholar4. ZimmermannDonovan BTJ: Hyperglycemic effect of insulin, Am. J. Physiol. 153: 197-204, 1948. CrossrefMedlineGoogle Scholar5. LowellFranklin FCW: Induced insulin resistance in the rabbit, J. Clin. Investigation 28: 199-206, 1949. 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PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byIron metabolism and the polycystic ovary syndromeIron Overload Disorders: Natural History, Pathogenesis, Diagnosis, and TherapyInsulin-Binding Antibodies of Serum and Insulin ResistanceDie Immunologie des InsulinsStudies on the diabetic syndrome of idiopathic haemochromatosisDisturbances in Carbohydrate Metabolism: Liver DiseaseGlycosuriaNeue Erkenntnisse in der Behandlung der chronischen Insulinresistenz und experimentelle Untersuchungen zu ihrer GeneseIdiopathic insulin-resistant diabetes mellitus 1 June 1953Volume 38, Issue 6Page: 1295-1306KeywordsAdolescentsComaDiabetes mellitusHemochromatosisHospital medicineInfectious diseasesInsulinInsulin resistanceLiver diseasesMedical services ePublished: 1 December 2008 Issue Published: 1 June 1953 PDF downloadLoading ...