tbuckley/cabot-search huggingface dataset:
Book: At The Side of Torture Survivors: Treating a Terrible Assault on Human Dignity Splintered Innocence: An Intuitive Approach to Treating War Trauma
Authors: L. Jones
Journal: BMJ (2002)

Eds Sepp Graessner, Norbert Gurris, Christian Pross Johns Hopkins University Press, $46.50/£31.50, pp 218 ISBN 0 8018 6627 8 Peter Heinl Brunner-Routledge, £15.99, pp 170 ISBN 0 415 22363 6 Rating: ![Graphic][1]</img>![Graphic][2]</img>![Graphic][3]</img>;![Graphic][4]</img>![Graphic][5]</img> At a meeting in 2000 the Royal College of Psychiatrists debated the existence of post-traumatic stress disorder (PTSD). The debate missed the point. In my experience of working in conflict areas it is perfectly possible to bag up people's presenting clusters of symptoms in this particular way. However, this label rarely serves a useful purpose. It fails to embrace … [1]: /embed/inline-graphic-1.gif [2]: /embed/inline-graphic-2.gif [3]: /embed/inline-graphic-3.gif [4]: /embed/inline-graphic-4.gif [5]: /embed/inline-graphic-5.gif
Efficacious hepatoma-targeted nanomedicine self-assembled from galactopeptide and doxorubicin driven by two-stage physical interactions
Authors: Jianxun Ding, Chunsheng Xiao, Yuce Li, Yilong Cheng, Nannan Wang, Chaoliang He, Xiuli Zhuang, Xiaojuan Zhu, Xuesi Chen
Journal: Journal of Controlled Release (2012)
Economic evaluation and society's health values: Price and value are different
Authors: Peter Davies
Journal: BMJ (2005)

EDITOR—I admire Coast's bravery in writing a penetrating review of health economics.1 I wonder if the problems go even deeper than she has acknowledged.

Firstly, I do not think that society is in tune with what its health values are.2 3 Even if society is in touch with these values any individual within it changes his or her values immediately he or …
Thyroid Dysfunction in the Ailing, Aging, and Aberrant
Authors: Laurence A. Gavin
Journal: JAMA (1980)

<h3>To the Editor.—</h3> In the editorial on thyroid dysfunction, Nusynowitz and Young (242:275, 1979) speculated on the possible usefulness of serum reverse triiodothyronine (T<sub>3</sub>) levels in differentiating sick patients with isolated hyperthyroxinemia (low or normal serum T<sub>3</sub>values) from sick patients with hyperthyroidism. We measured serum reverse T<sub>3</sub>concentrations in the group of sick patients described in the same issue ofThe Journal(242:251, 1979).<sup>1</sup>The mean serum reverse T<sub>3</sub>concentration was significantly higher in the study group, at 65±20 ng/dL, vs 24±5 ng/dL (<i>P</i>&lt;.05) in normal control subjects. Segregation of the sick patients into the "euthyroid sick" and "hyperthyroid sick" groups, however, revealed no significant difference in the reverse T<sub>3</sub>means (61±20 ng/dL and 43±7 ng/dL, respectively). Thus, serum reverse T<sub>3</sub>values seem to be of no value in distinguishing sick euthyroid patients with high serum free thyroxine indices from sick hyperthyroid patients.
Defining the dermatological content of the undergraduate medical curriculum: a modified Delphi study
Authors: R. Clayton, R. Perera, S. Burge
Journal: British Journal of Dermatology (2006)

Background Dermatological problems are common, but in undergraduate medical courses time for learning dermatology and teaching dermatology is limited. The Delphi technique has been used in other specialties to define undergraduate and postgraduate curricula and to reach consensus on what is important. Objectives To identify the core dermatological content of the undergraduate medical curriculum. Methods Modified Delphi technique. A questionnaire was designed after review of previous recommendations made by dermatologists. Items were written as explicit learning outcomes. A multidisciplinary panel of 66 individuals responded. Outcomes were rated using a Likert scale (1–5). Results Fifty-three learning outcomes were rated 'very important'. We recommend that these are included in the content of U.K. undergraduate medical core curricula. Conclusions A multidisciplinary panel identified dermatological learning outcomes that should be achieved by all medical graduates. Undergraduate medical curricula must provide sufficient resources for learning, teaching and assessment of dermatology so that graduates achieve these outcomes.
Sporotrichosis in Western Pennsylvania
Authors: James B. Hanrahan
Journal: JAMA (1966)

SPOROTRICHOSIS has been reported infrequently from Western Pennsylvania.<sup>1</sup>While the paucity of reports may not reflect the true occurrence of the disease in this area, it is unlikely that there have been any large outbreaks such as have occurred recently in Vermont and Florida.<sup>2,3</sup>During the past ten years, two cases of cutaneous sporotrichosis have been seen at the Western Pennsylvania Hospital. These cases are being reported because they occurred in nonhorticultural workers, and because one case represents an unusual complication of cutaneous sporotrichosis. <h3>Report of Cases</h3><h3>Case 1.—</h3> This 63-year-old veterinarian, who resided and practiced in a Pittsburgh suburb, was first seen by his physician on July 12, 1957, with an ulcer on his right forearm and lymphangitis of his right upper arm occurring after a scratch from an animal under his care. The lesion was cultured and excised. Histologic examination revealed a granulomatous reaction and cultures
Neuronal Regeneration after Stroke
Authors: Zurab Nadareishvili, John Hallenbeck
Journal: New England Journal of Medicine (2003)

Neurogenesis in the mammalian central nervous system was formerly considered to end shortly after birth. We now know that neural stem cells exist not only in the developing nervous system, but also in the nervous systems of all adult mammalian organisms, including humans.1 In the adult brain, new neurons are generated primarily in two regions: the subventricular zone and the subgranular zone1 of the hippocampal dentate gyrus. This neurogenesis occurs under normal conditions, and the generation of new neurons can increase under pathologic conditions, such as the brain ischemia that typifies a stroke.2 Whether newly formed neurons migrate to the . . .
Case 37-1975
Authors: Richard C. Cabot, Robert E. Scully, James J. Galdabini, Betty U. McNeely, Harley A. Haynes, Eugene J. Mark
Journal: New England Journal of Medicine (1975)

Presentation of Case First admission. An 87-year-old woman was admitted to the hospital because of dermatitis.She was well until 21 months previously, when dryness and scaling of the skin developed. A physician prescribed a fluocinonide ointment, and the skin changes improved. Sixteen months before entry she returned to her physician because of cracking of the skin of the fingers. Fine scaling of the face with minimal erythema was observed. Cellulitis of the leg was treated with clindamycin. Two months before admission she returned because of a rash on the fingers that resembled psoriasis. Scaling of the scalp and . . .
Six months open label trial of leflunomide in active ankylosing spondylitis
Authors: H Haibel
Journal: Annals of the Rheumatic Diseases (2004)

To examine the potential therapeutic effects of leflunomide in patients with active AS in an open label study.Twenty patients with AS fulfilling the 1984 modified New York criteria with a Bath AS Disease Activity Index (BASDAI) >3 were given leflunomide for 6 months. Clinical outcome assessments included disease activity (BASDAI), function (BASFI), metrology (BASMI), patient's and physician's global assessment, peripheral joint assessment, quality of life (SF-36), global pain, and CRP. Primary end point was a reduction of disease activity as measured by the BASDAI of >25% at 6 months.A BASDAI 25% improvement was noted in 5/20 (25%) patients and a BASDAI 50% improvement in 4/20 (20%) patients. The absolute BASDAI did not change significantly over the 6 month study (4.9 at baseline v 4.3 at week 24, p>0.05). Similarly, no significant change was found for the BASFI, BASMI, patient's and physician's global assessment, SF-36 mental component, and CRP. For the 10 patients with peripheral arthritis, the mean number of inflamed joints was significantly reduced from 1.7 at baseline to 0.9 at week 12 (p = 0.034) and 0.2 at week 24 (p = 0.039).In this open study of patients with active AS only those with peripheral arthritis improved significantly with leflunomide treatment. Axial symptoms did not improve.
AN ABDUCTION SPLINT FOR THE FEMUR
Authors: D. W. Crile
Journal: BMJ (1918)

THE war has demonstrated that for the early treatment and transportation of patients with fractures of the femur Thomas's knee-splint is the best general utility splint, and bhat rigid exteusiow from the ischial tuberosity is practical.There is, however, a class of fractures of the femur-that is, those iti the upper third- which presents great di f ficuty to treat-*ment with T hom as's splint, par- ticuiilarly ~~~w h4enaccom panied
People with AIDS are dying because of inadequate staffing, says MSF
Authors: Pat Sidley
Journal: BMJ (2007)

Wiltshire police investigating unspecified allegations against a paediatrician at Southampton General Hospital are seeking expert medical evidence outside the UK.The case concerns a paediatrician who was involved in the care of a child whose mother was later charged with murder.Marianne Williams, then 22, was charged in 2004 with the murder of her 15 month old son, Joshua Taylor, whom she was alleged to have poisoned with salt.She was found not guilty in October last year after a six week trial at Winchester Crown Court.Wiltshire police officers are also under investigation for their role in the case.The Independent Police Complaints Commission said that it was "midway through" an investigation into a complaint about the conduct of the criminal investigation.Six officers had been served with official notice of the inquiry, although "this in no way implies guilt or wrongdoing on the part of any officer," the commission said.Detective Superintendent James Vaughan, the officer leading the Wiltshire force's inquiry into the allegations against the doctor, confirmed that Wiltshire Police would not be seeking medical advice in the case from any British doctors-a claim posted on the website forum Mothers Against Munchausen Allegations."In order to maintain the confidence of Joshua's family, and to identify an independent specialist who has had no connection with this or any other similar sets of circumstances in the United Kingdom, it has been necessary to seek assistance from overseas," Detective Superintendent Vaughan said.This was, he insisted, "not a reflection on the Wiltshire police's confidence in the United Kingdom experts."However, the Royal College of Paediatrics and Child Health said it was "confident that we have eminent experts in the UK who can offer an independent and authoritative opinion." Police look abroad for salt case expertUK NEWS Remedy UK loses court case, p1134
Association Between Colorectal Cancer Survival Outcomes and GWAS-Identified Colorectal Cancer Susceptibility Polymorphism in Korean Population
Authors: Kang Byung Woog, Kim Jong Gwang, Chae Yee Soo, Jung Min Kyu, Jang Yun-Jin, Kwon Ohkyoung, Jeon Hyo-sung
Journal: Annals of Oncology (2014)
Burkholderia cepacia and Nebulized Albuterol
Authors: Richard J. Hamill
Journal: Annals of Internal Medicine (1996)

Letters15 January 1996Burkholderia cepacia and Nebulized AlbuterolRichard J. Hamill, MD, Richard M. Cadle, PharmD, PharmD, and Maureen A. Koza, RN, CICRichard J. Hamill, MDVeterans Affairs Medical Center; Houston, TX 77030Search for more papers by this author, Richard M. Cadle, PharmD, PharmDVeterans Affairs Medical Center; Houston, TX 77030Search for more papers by this author, and Maureen A. Koza, RN, CICVeterans Affairs Medical Center; Houston, TX 77030Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-124-2-199601150-00020 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail IN RESPONSE:We thank Dr. Scharer for his comments and share his concerns about the use of multiple-dose medications for inhalation therapy. Multiple-dose medication vials are commonly used because they offer reduced drug costs and convenience compared with single-dose vials. In fiscal year 1995, the Houston Veterans Affairs Medical Center purchased 10 000 multiple-dose bottles (40 doses/bottle) of albuterol for nebulization at a cost of $33 000. This figure translates to a cost of $0.08 per treatment if all 400 000 potential treatments are given. Unit dose vials cost our hospital $0.40 per vial; at this price, the same 400 ...References1. Bennett SN, McNeil MM, Bland LA, Arduino MJ, Villarino ME, Perrotta DM, et al. Postoperative infections traced to contamination of an intravenous anesthetic, propofol. N Engl J Med. 1995; 333:147-54. Google Scholar2. Fridkin SK, Pear SM, Williamson TH, Galgiani JN, Jarvis WR. The role of understaffing in intravascular catheter complications [Abstract]. Clin Infect Dis. 1994; 19:583. Google Scholar Author, Article, and Disclosure InformationAffiliations: Veterans Affairs Medical Center; Houston, TX 77030 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byBurkholderia cepacia Lower Respiratory Tract Infection Associated With Exposure to a Respiratory Therapist 15 January 1996Volume 124, Issue 2Page: 274KeywordsChloridesDrugsHealth careInhalationNosocomial infectionsPreservativesPseudomonasPseudomonas infectionsRespiratory systemUpper respiratory tract infections Issue Published: 15 January 1996 Copyright & PermissionsCopyright © 1996 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
The Epidemiology and Cost of Inpatient Care for Peripheral Vascular Disease, Infection, Neuropathy, and Ulceration in Diabetes
Authors: Craig J Currie, Christopher LL Morgan, John R Peters
Journal: Diabetes Care (1998)

OBJECTIVE To describe the epidemiology and costs of the acute care of peripheral vascular disease, infection, neuropathy, and ulceration in a U.K. population with special consideration of those patients with diabetes. RESEARCH DESIGN AND METHODS Routine data describing inpatient care for a 4-year period were analyzed (financial years 1991/1992 to 1994/1995). These data had undergone record-linkage to draw together records from the same patients, and records of patients with diabetes were flagged. Cost estimates were determined by attributing a diagnosis-related group cost-weight to each record. RESULTS A total of 4,245 admissions (1.2% of all admissions) had a primary diagnosis of peripheral vascular disease, infection, neuropathy, or ulceration, and 7,379 (2.1%) admissions had these categories recorded in any one of six diagnostic fields. These figures were generated by 3,159 and 4,751 patients, respectively. This represented a range of crude annual incidence of admission of between 1.9 and 2.9 per 1,000 people. Patients with diabetes accounted for 625 (15.4%) of primary admissions, a crude annual incidence of admission of 18.8 per 1,000. The age-standardized relative risk of admission for patients with diabetes to the nondiabetic population was 7.61 for men and 6.85 for women. The length of stay for patients with diabetes was almost twice that of the nondiabetic population (15.5 vs. 8.7 days). The relative risk of hospital mortality (diabetes vs. non-diabetes) was 2.83. Surgical procedures were carried out on 857 patients, 272 (31.2%) with diabetes. This represented an age-standardized relative risk of 31.19. The estimated cost of admissions for primary diagnoses in these categories over 4 years was 6,128,211 pounds ($9,743,855). Patients with diabetes accounted for 1,236,623 pounds ($1,966,230), an excess of 87% attributable to the diabetic state. CONCLUSIONS Diabetes is confirmed as a significant risk factor for peripheral vascular disease, infection, neuropathy, and ulceration. The severity of these disorders in terms of increased risk of hospital mortality, length of stay, and risk of surgical procedure is also demonstrated for those patients with diabetes.
Report calls for more care for people wanting to die at home
Authors: Zosia Kmietowicz
Journal: BMJ (2004)

More needs to be done to allow people who wish to die at home to be able to do so, says a report from the House of Commons Health Committee.

Although 56% of people who are terminally ill say they would prefer to die at home, currently only 20% do, says the report on palliative care. Most terminally ill people (56%) die in hospital under the care of generalists.

“The right to a good death should be fundamental,” said David Hinchliffe, chairman of the committee. …
Contamination of Intravenous Infusion Fluid: Effects of Changing Administration Sets
Authors: ALFRED E. BUXTON
Journal: Annals of Internal Medicine (1979)

Daily change of intravenous (i.v.) infusion administration sets has been recommended by the Center for Disease Control since 1973 to reduce the risk of infusion bacteremia. To evaluate this recommendation, we undertook a prospective, randomized, controlled trial that compared the rates of i.v.-associated bacteremia, in-use i.v. fluid contamination, and phlebitis in 300 patients whose administration sets were changed every 24 h with those in 300 patients whose administration sets were changed every 48 h. No i.v.-associated bacteremia occurred. Twelve of 600 infusions (2%) had positive infusion-fluid cultures: five in one group and seven in the other. Both groups had comparable rates of phlebitis. In this study population with low rates of fluid contamination, no benefit accrued from changing the administration sets every 24 h instead of every 48 h. In hospitals with low rates of fluid contamination, the routine changing of i.v. administration sets every 48 h will result in substantial financial savings.
Arthritis: a Quarter Century of Research
Authors: B. L. Hazleman
Journal: Annals of the Rheumatic Diseases (1978)

consecutive occasions by 5-day courses of intravenously not granted.administered cytosine arabinoside 100 mg/day.These data provide further evidence of the beneficial This patient was followed by us for a further period of effect of cytosine arabinoside in the symptomatic treat-22 months.During that time, while the haematological ment of patients with this condition.picture remained unchanged, he suffered from eleven episodes of excrutiating bone pain, always responsive to J. AsHEROV, Y. SHOENFELD, and J. PKHAS the same treatment.Repeated skeletal x-rays and bone Department of Medicine 'D', scans showed no osteolytic lesions.In December 1977 a
Lack of Correlation Between Physical Exam(PE), Mini RQLQ (MRQLQ), and Nasal Peak Inspiratory Flow (nPIF) as Measures of Nasal Congestion in Obstructive Sleep Apnea (OSA) Patients With Rhinitis
Authors: M.R. Rupp, A.S. Baran, G.D. Marshall
Journal: Journal of Allergy and Clinical Immunology (2007)
Ultrastructural changes in the nasal mucosa of Fischer 344 rats and B6C3F1 mice following an acute exposure to methyl isocyanate.
Authors: L C Uraih, F A Talley, K Mitsumori, B N Gupta, J R Bucher, G A Boorman
Journal: Environmental Health Perspectives (1987)

Male rats and male mice received a single 2-hr exposure to 0 (control), 10, or 30 ppm of methyl isocyanate and were sacrificed after 1, 3, 14, or 90 days to assess the ultrastructural changes in the nasal mucosa by transmission electron microscopy. One day after exposure to methyl isocyanate, there were widespread areas of necrosis and degeneration of the respiratory and olfactory epithelium of rats and mice in the 10 ppm and 30 ppm groups. Qualitatively the ultrastructural findings were similar for both exposure groups and species. Degeneration followed by rapid regeneration was observed for both respiratory and olfactory epithelia but was most striking for olfactory epithelium in the dorsal meatus. Three days after the exposure, the olfactory epithelium was two to three cell layers thick due to a loss of supporting cells, olfactory neurons, and basal cells. By 14 days after exposure, the olfactory epithelium was composed of a heterogeneous cell population three to five cell layers thick. At 90 days following exposure, the epithelium was of normal thickness (eight to ten cell layers), with normal architectural arrangement, and composed of well-differentiated cells that appeared similar to those of controls. There were several findings that suggested the epithelial cells of Bowman's glands were the progenitor for the regenerating supporting cells of the olfactory epithelium. This study demonstrated that the respiratory and olfactory epithelium is capable of complete structural regeneration after an acute destruction by methyl isocyanate.
Signal transduction pathways of angiotensin II--induced c-fos gene expression in cardiac myocytes in vitro. Roles of phospholipid-derived second messengers.
Authors: J Sadoshima, S Izumo
Journal: Circulation Research (1993)

Angiotensin II (Ang II) causes a rapid induction of immediate-early genes and hypertrophy in the cardiac myocyte. However, the signaling mechanism of Ang II-induced immediate-early gene expression in cardiac myocytes has not been characterized. Therefore, we examined signal transduction of Ang II in neonatal rat cardiac myocytes, using c-fos gene expression as a model system. Transient transfection of c-fos reporter gene constructs indicated that the serum response element is not only required but also sufficient for Ang II-induced activation of the c-fos promoter. Ang II is known to cause an increase in [Ca2+]i. We found that Ang II also causes a small increase in cAMP in cardiac myocytes. However, the Ca2+/cAMP response element of the c-fos gene was not sufficient to confer Ang II responsiveness to the c-fos promoter, and inhibitors of protein kinase A had no effects on Ang II-induced c-fos expression. On the other hand, chelating intracellular Ca2+ with BAPTA-AM inhibited Ang II-induced c-fos expression in a dose-dependent manner, suggesting that Ca2+ is required for Ang II-induced signaling. Measurements of phospholipid-derived second messengers revealed that Ang II increased production of inositol trisphosphate, diacylglycerol, phosphatidic acid, and arachidonic acids, resulting in a sustained increase in protein kinase C activity. This and other evidence suggest that Ang II activates phospholipase C, phospholipase D, and possibly phospholipase A2. All of these second-messenger systems are activated through the AT1 receptor. Pharmacological inhibition of phospholipase C or downregulation of protein kinase C significantly suppressed Ang II-induced c-fos expression. In conclusion, Ang II activates multiple phospholipid-derived second-messenger systems via the AT1 receptor in cardiac myocytes. Among these second-messenger systems, phospholipase C and protein kinase C seem essential for Ang II-induced c-fos gene expression, whereas Ca2+ may play a permissive role. Finally, the "Ang II response element" of the c-fos gene maps to the protein kinase C-dependent portion of the serum response element.
A CASE OF TINEA NIGRA IN BRITAIN
Authors: H. W. Chadfield, C. K. Campbell
Journal: British Journal of Dermatology (1972)

Journal Article A CASE OF TINEA NIGRA IN BRITAIN Get access H. W. Chadfield, H. W. Chadfield Royal Hospital, Wolverhampton WV2 IBT, and M.R.C. Unit for the Experimental Pathology of the Skin, University of Birmingham Search for other works by this author on: Oxford Academic Google Scholar C. K. Campbell C. K. Campbell Royal Hospital, Wolverhampton WV2 IBT, and M.R.C. Unit for the Experimental Pathology of the Skin, University of Birmingham Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 87, Issue 5, 1 November 1972, Pages 505–508, https://doi.org/10.1111/j.1365-2133.1972.tb01600.x Published: 01 November 1972 Article history Accepted: 17 May 1972 Published: 01 November 1972