tbuckley/cabot-search huggingface dataset:
Abstract 13139: Decline in Clopidogrel Discontinuation Rates and its Association with Mortality after Acute Myocardial Infarction
Authors: Amit P Amin, Adam C Salisbury, Kimberly Reid, P. Michael Ho, Yevgeniy Khariton, Carole Decker, David J Cohen, John Spertus
Journal: Circulation (2010)

Introduction:  While clopidogrel is recommended for 12 months after percutaneous coronary intervention (PCI) with drug eluting stents (DES) for acute myocardial infarction (AMI), we found in a prior study that clopidogrel discontinuation (CD) occurred commonly within 30 days of hospital discharge and was associated with rehospitalization and mortality. Whether recent increased awareness of the importance of clopidogrel has translated into improved adherence is unknown.   Methods:  We examined 2114 AMI patients treated with DES enrolled in the multicenter PREMIER (years 2003–2004, n= 549) and TRIUMPH (years 2004–2008, n=1565) AMI registries. The primary outcome variable was CD and a secondary outcome was 1-year mortality, which was examined using Kaplan-Meier and Cox regression analyses (adjusted for age and site).   Results:  Among 2114 AMI patients undergoing PCI with DES in both registries (25% diabetics, 32% females, mean age 59 ± 12 years, mean DES stents used 1.6 ± 0.9), CD within the first 30 days after PCI with DES declined from 13.8% in PREMIER registry to 5.4% in the contemporary TRIUMPH registry (p   Conclusions:  Early clopidogrel discontinuation rates among AMI patients treated with DES have declined dramatically over time, yet there remains a higher risk of mortality for those stopping clopidogrel prematurely. Further efforts to minimize early CD through education or better patient selection for DES are important.
School avoidance and social phobia triggered by haloperidol in patients with Tourette's disorder
Authors: E J Mikkelsen, J Detlor, D J Cohen
Journal: American Journal of Psychiatry (1981)

Fifteen patients with Tourette's disorder developed school and work avoidance syndromes when treated with low doses (mean 2.5 mg/day) of haloperidol for short periods of time (mean, 8 weeks). The phobic syndromes disappeared completely with discontinuation or reduction of the haloperidol dose. Haloperidol's effects on dopaminergic functioning support a role for catecholamines in the pathogenesis of phobic syndromes. It is not known whether phobias are precipitated by haloperidol only in patients with Tourette's disorder as a consequence of the specific metabolic alterations in this disorder or are a medication side effect in other psychiatric disorders as well.
Abstract 15663: MicroRNA-144/451 Cluster Confers Protection against Simulated Ischemia/Reperfusion-Induced Cardiomyocyte Death via Activation of COX-2
Authors: Xiaowei Zhang, Xiaohong Wang, Hongyan Zhu, Guo-Chang Fan
Journal: Circulation (2010)

Background: Among the identified microRNAs (miRs) thus far, ∼50% of mammalian miRs are clustered in the genome and transcribed as polycistronic primary transcripts. However, whether clustered miRs ...
Diabetes Mellitus and Exercise
Authors: J Rybka
Journal: Diabetes Care (1990)

The study deals with the subject of exercise in diabetic patients, with particular emphasis on acute physical stress in type--I and type--II diabetics. The principal task was to define metabolic changes as they occur in the diabetic subjected to acute stress induced by exercise, in comparison with non-diabetics; metabolic changes during prolonged stress as well as during the period of rest; and finally, to propose, on the basis of authors' experimental results and detailed literature research, appropriate rules of procedure for prescriptive exercise for the individual patient. There were 120 subjects divided into 8 groups. Using primarily a bicycle ergometer, the members of the individual groups were subjected to physical stress of various intensity and duration. A detailed analysis of each subject's metabolic response was performed, involving an assessment of 35 physiological and biochemical parameters, with main focus on determining biochemical changes. The study results are presented in detail both with respect to the metabolic response to a given stress in individual groups and comparatively for individual parameters with regard to specific stress rates and groups. Significant differences were found in the metabolic responses concerning the following parameters: acid-base balance, potassium, triglycerols, glucose, cholesterol, FFA, free glycerol, lactate, uric acid. On the basis of the results of experimental measurements, the following algorithm has been designed for prescribing exercise to diabetics: appropriate motivation; determination of the type of exercise; determination of the intensity of exercise; determination of the duration of exercise; respecting related contraindications and complications. A conclusion has been made that provided all possible risks and contraindications as well as prescription guidelines are respected, exercise is to be considered one of the basic principles of diabetes management.
Methinks the professor doth protest too much
Authors: Paul W Dimmock
Journal: BMJ (2008)

Vitamin D deficiency is widespread in Scotland I agree with Holick 1 and Sievenpiper et al 2 about the urgent need to highlight the neglected subject of vitamin D deficiency in the United Kingdom.We have found in our general practice in Edinburgh a (to us) surprisingly high prevalence of gross vitamin D deficiency.The deficiency affects not only our South Asian patients but also a considerable number of those with white skin colour.Between 2005 and 2007, blood samples were taken from 99 patients aged 15-85.We included patients suspected of having a possible vitamin D deficiency: patients of South Asian origin or other ethnic minorities, patients with vague musculoskeletal symptoms or overweight, patients taking antiepileptic drugs, patients using sunscreen or make up, housebound patients, and patients with little exposure to sunlight.The figure shows our as yet unpublished results.According to the definitions of most vitamin D researchers, insufficient vitamin D concentrations are those below 75 nmol/l.In our sample only 2% had a sufficient vitamin D concentration.Measurements below 25 nmol/l are defined as severe deficiency; in our sample, the proportion was 47%.We select the letters for these pages from the rapid responses posted on bmj.com favouring those received within five days of publication of the article to which they refer.Letters are thus an early selection of rapid responses on a particular topic.
Abstract 2848: Is There a Benefit to Bivalirudin and Glycoprotein 2b/3a Receptor Inhibitor Combination Therapy in Percutaneous Coronary Intervention?
Authors: Srihari S Naidu, Michael J Levine, Robert M Minutello, Manish A Parikh, Geoffrey W Bergman, Shing-Chiu Wong
Journal: Circulation (2006)
Epigenetic field effects: Potential applications for detection of occult high-grade prostate cancer.
Authors: Sandra Marlene Gaston, William E. Grizzle, Leander Van Neste, Joseph Bigley, James Yen, George W Adams, Gary P Kearney
Journal: Journal of Clinical Oncology (2015)

20 Background: Needle biopsy (Bx) pathology is central to the diagnosis and management of prostate cancer (PCa), but Bx sampling error can result in an underestimate of Gleason grade (GS). Epigenetic DNA hypermethylation markers associated with PCa are commonly observed in histologically benign tissue adjacent to a cancer focus. Such field effects are the basis for a diagnostic test in which the absence of GSTP1, APC and RASSF1 hypermethylation in benign Bxs is associated with a low risk of “missed” PCa. Relatively low methylation thresholds are used for the current epigenetic test (ConfirmMDx) that is designed to be sensitive to any occult cancer, regardless of GS. We are evaluating new prototype epigenetic tests that are designed to be sensitive to the GS of an occult PCa. Methods: DNA was extracted from prostate bx tissue prints and used for quantitative methylation-specific PCR for GSTP1, APC and RASSF1. Results were computed as levels of marker methylation relative to a common reference gene. Each of 12 cores was tested from a series of 102 Bx patients: 20 diagnosed with no cancer (Group 1), 46 with GS 6 PCa (Group 2) and 36 with GS 7 PCa (Group 3). Results: For all 3 markers, we observed a positive correlation between the highest level of hypermethylation in the benign cores and in the same-patient cancer cores. This correlation was strongest for APC (P &lt;0.0001). For GSTP1 and APC, hypermethylation intensity in the benign cores was also positively correlated with the overall GS. Interestingly, for each marker, the GS 6 cores from Group 3 (overall diagnosis GS 7) showed significantly higher levels of hypermethylation than the GS 6 cores from Group 2 (overall GS 6). The strongest correlation between the level of GS 6 core hypermethylation and overall GS was observed for GSTP1(P=0.0002). Conclusions: For GSTP1, APC and RASSF1, the intensity of field effect hypermethylation in benign Bx cores was positively correlated with the level of hypermethylation present in the cancer cores from the same patient. In GS 6 cancer cores, the intensity of hypermethylation is higher in subjects who also have cores of GS 7 than in subjects with GS 6 cores only. Both findings support the feasibility of an epigenetic test that is sensitive to the GS of an occult PCa.
Abstract 2161: Left Atrium Reverse Remodeling After Pulmonary Vein Isolation. Will It Be a Predictor for Non-recurrence of Atrial Fibrillation?
Authors: kiyotake Ishikawa, Yukihiko Yoshida, Sumio Morita, Kenji Furusawa, Noriyoshi Kanemura, Luke Yoshida, Tousei Hashimoto, Takashi Yamamoto, Yutaka Aoyama, Masateru Takigawa, Natsuo Inoue, Yasushi Tatematsu, Mamoru Nanasato, Haruo Hirayama
Journal: Circulation (2008)

Background: Left atrium (LA) dilation plays an important role in development and persistence of atrial fibrillation (AF). Some cases show structural reverse remodeling of LA after catheter ablation of AF. The aim of this study was to assess the clinical significance of LA reverse remodeling. Method and Results: Echocardiographic data before and after ablation was obtained in 173 cases who underwent pulmonary vein isolation from January 2006 to April 2008 (74.0% men, 61.0±11 years old; paroxysmal AF 114, persistent AF 34, permanent AF 25). Mean atrial diameter before ablation was 39.0±6.1mm (paroxysmal 37.7±5.6mm, persistent 40.7±5.3mm, and permanent 43.0±6.8mm) and LA reverse remodeling was defined as 10% decrement of LA transverse diameter. Half of the cases were taking anti-arrhythmic drugs after ablation, and AF recurrence occurred in 16.8% (29/173) during mean follow up period of 8.5±6.3 months. Reverse remodeling of LA was seen in 34.1% (59/173) and AF recurrence rate in this group was 11.9% (7/59), whereas 19.3% (22/114) without reverse remodeling (P=0.29). However, limited in patients with LA diameter over 40mm (44.5%; 77/173), 3.2% (1/31) of AF recurrence was seen in those with reverse remodeling, while 21.7% (10/46) without reverse remodeling (P=0.04). LA reverse remodeling was observed significantly frequent in patients without history of hypertension(41.5% without hypertension vs 25.6% with hypertension, P=0.036). Conclusion: LA reverse remodeling after catheter ablation of AF in dilated LA patient is a simple and useful predictor for non-recurrence of AF. Hypertension could be a disturbance for LA reverse remodeling.
Dose-Response Analyses Of Momelotinib (CYT387), a JAK1 and JAK2 Inhibitor, From a Phase I/II Study (CCL09101) In Treatment Of Myelofibrosis
Authors: Yan Xin, Lixin Shao, Wei Deng, Demi Niforos, Mark Kowalski, Linda M Bavisotto, Jun Kawashima, Susie Jun, Helen Collins, Srinivasan Ramanathan
Journal: Blood (2013)
Abstract 10701: A Phase 1, Randomized, Double-Blind, Placebo-Controlled, Ascending Single Dose Study to Evaluate the Safety, Tolerability and Pharmacodynamics of AMG145
Authors: Clapton Dias, Adam Shaywitz, Brian Smith, Maurice Emery, Gao Bing, John Gibbs, Bill Wishner, Dina Stolman, Caroline Crispino, Blaire Cook, Alex Colbert, Marc Retter, Ren Xu, Mark Matson
Journal: Circulation (2011)
Abstract 2289: Is Revascularization Alone Truly Sufficient in Patients With Mild Mitral Regurgitation?: Echocardiographic Follow-up of Mild Ischemic Mitral Regurgitation After Isolated Coronary Artery Bypass Grafting
Authors: Tetsuhiro Yamano, A. Marc Gillinov, Kunitsugu Takasaki, Roberto M Saraiva, Yoshiki Matsumura, Manatomo Toyono, Takahiro Shiota
Journal: Circulation (2008)
High Risk Features Improve Prognostication in Resected Stage I Nsclc: a Single Institution Retrospective Review
Authors: Aaron R. Hansen, Maree Colosimo, Belinda E. Clarke, Edwina E. Duhig, Kevin Matar, Morgan Windsor, Rayleen Bowman, Ian A. Yang, Kwun M. Fong
Journal: Journal of Thoracic Oncology (2011)
CHEMICAL STUDIES OF THE BLOOD IN HIGH INTESTINAL OBSTRUCTION
Authors: William DeWitt Andrus, George M. Guest, Richard F. Gates, Alta Ashley
Journal: Journal of Clinical Investigation (1932)

In the preceding paper (Guest and Andrus, 1932) certain of the principal changes occurring in the blood of dogs following simple pyloric or mid-duodenal obstruction have been discussed.Experiments were reported in which the distribution of phosphorus in the blood of dogs with obstruction was determined, and changes in various fractions of the blood phosphorus were correlated with other chemical changes of the blood which are generally known to be associated with intes- tinal obstruction.The greatest change in the blood phosphorus was in that fraction designated as the "organic acid-soluble ester-P" practi- cally all of which is contained in the cells.Changes in the chloride content of both plasma and cells were compared with concomitant changes in the distribution of phosphorus, and a close correlation be- tween the progressive losses of chloride from the blood cells and the increases of the ester-P of the cells was demonstrated.From these findings it was concluded that in the acid-base equilibrium of the cells these organic phosphorus compounds had some sort of a reciprocal relationship to the cell chloride, and that as these phosphorus com- pounds increased they were bound to the alkali in the cells from which chloride was lost, much as HCO3' is known to be retained by the alkali of the blood from which Cl' is lost.In those experiments it was also shown that the parenteral administration of NaCl solution prevented increases of ester-P in the cells to about the same degree that it pre- vented losses of chloride.The two theories most commonly accepted in explanation of the cause of death in intestinal obstruction are: (1) that death is due to dehydration and disturbance of the acid-base equilibrium of the body which follows the loss of electrolytes and water by vomiting and by failure of reabsorption of gastro-intestinal secretions from the obstructed bowel; (2) that death is due to a state of intoxication of the tissues brought about by toxic substances absorbed from the obstructed bowel.
Abstract 16433: Advanced Atrial Tissue Fibrosis Quantified Using Late-Gadolinium Enhanced Cardiac MRI is Associated with Significant Ventricular Conduction Delay
Authors: Genaro Fernandez, Aamir Amin, Anya G Mihaylova, Nathan S Burgon, Nassir F Marrouche, Nazem Akoum
Journal: Circulation (2012)

Introduction: Late-gadolinium enhanced cardiac MRI (LGE-MRI) is used to quantify atrial tissue fibrosis. We studied the impact of atrial fibrosis in atrial fibrillation (AF) on ventricular tissue. ...
Donor Leukocyte Infusion for Leukemic Relapse After Allogeneic Marrow Transplantation: Lack of Residual Donor Hematopoiesis Predicts Aplasia
Authors: Felix Keil, Oskar A. Haas, Gerhard Fritsch, Peter Kalhs, Klaus Lechner, Christine Mannhalter, Elisabeth Reiter, Dietger Niederwieser, Paul Hoecker, Hildegard T. Greinix
Journal: Blood (1997)
Abstract 4692: Impact of Pressure Recovery on Diagnosis of Severe Aortic Stenosis in Asymptomatic Patients. (A SEAS Substudy)
Authors: Edda Bahlmann, Dana Cramariuc, Eva Gerdts, Christa Gohlke-Baerwolf, Chritoph Nienaber, Karl Heinz Kuck, Simon Ray
Journal: Circulation (2008)

Background: Downstream pressure recovery (PR) in the aorta affects transvalvular pressure gradient measurement and calculation of aortic valve area by continuity equation in patients with aortic stenosis (AS). Methods: To assess the clinical importance of PR on evaluation of severity of AS, echocardiographic data in 1562 patients with asymptomatic aortic stenosis (mean age 67 ± 10, 39% women, 51% hypertensive) recruited in the Simvastatin Ezitimibe in Aortic Stenosis (SEAS) study was used. The inner diameter of the ascending aorta was measured at annulus and at sinutubular junction. The aortic valve area (AVAI) was calculated from annular diameter and velocity time integrals from sub- and transaortic flow by Doppler. PR and PR corrected AVAI assessed as energy loss index (ELI) were calculated by previously published equations. Severe aortic stenosis was defined as AVAI &lt;0.60cm 2 /m 2 and ELI &lt;0.55cm 2 /m 2 , respectively. Patients were grouped into tertiles of peak transaortic Doppler velocity (&lt;2.79, 2.79 –3.32, ≥3.33 m/sec, respectively). Results: In the total study population, PR ranged from 1.22–16.75 mmHg (mean 5.9±2.3), AVAI from 0.20 –1.85 cm 2 /m 2 (mean 0.67±0.22) and ELI from 0.22–5.94 cm 2 /m 2 (mean 0.89±0.45). PR increased significantly with severity of AS (Table 1 ). Both AVAI and ELI decreased with increasing peak transaortic velocity, and the overestimation of AS severity by using unadjusted AVA was largest in the lowest tertile (Table 1 ). Conclusion: Severity of AS is often overestimated in milder degrees of asymptomatic AS if correction for pressure recovery is not performed. Adjustment of AVA for the effect of energy loss should be performed routinely, and this may be especially important for accuracy of severity assessment in patients with relatively low transvalvular velocities. Table 1
ILLNESS DUE TO HAVING BECOME CAUGHT IN A TRAP
Authors: W C ALVAREZ
Journal: Annals of Internal Medicine (1954)

Article1 April 1954ILLNESS DUE TO HAVING BECOME CAUGHT IN A TRAPWALTER C. ALVAREZ, M.D., F.A.C.P.WALTER C. ALVAREZ, M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-40-4-774 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptIn technical speech, this paper might be entitled "Situational Neuroses," but I fear that this term would mean little to most physicians, untrained as they are in psychiatry. I much prefer to express the idea of the patient's being caught in a trap; this means something definite that everyone can understand.Some may ask, But why didn't you put this article in a psychiatric journal? And the answer is, I very much want non-psychiatrists to make the acquaintance of this fairly common but as yet seldom recognized disease. That information about it is needed can be seen from the fact... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Chicago, Illinois*Received for publication September 2, 1953. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byFundamental research at primary care levelBody Fluids and Neuro-Psychologic Disturbances 1 April 1954Volume 40, Issue 4Page: 774-783KeywordsFear ePublished: 1 December 2008 Issue Published: 1 April 1954 PDF downloadLoading ...
New Home for Nation’s Research Hospital
Authors: Lynne Lamberg
Journal: JAMA (2005)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Second-trimester markers of fetal size in schizophrenia: a study of monozygotic twins
Authors: H S Bracha, E F Torrey, I I Gottesman, L B Bigelow, C Cunniff
Journal: American Journal of Psychiatry (1992)

Since the second prenatal trimester is the critical period of massive neural cell migration to the cortex, and fingertip dermal cells migrate to form ridges during this same period, the authors sought to determine whether there are differences in fingertip ridge count in pairs of monozygotic twins discordant for schizophrenia, possibly indicating that a prenatal anatomical insult affected the twins differently.The fingertip dermal ridges of 30 pairs of monozygotic twins (23 pairs in which the twins were discordant for schizophrenia and seven pairs in which both twins were normal) were counted by two persons trained in anthropometric research. Intrapair differences in the counts were then measured, and the differences among the pairs of normal twins were compared with the differences among the pairs discordant for schizophrenia.The twins discordant for schizophrenia had significantly greater absolute intrapair differences in total finger ridge count and significantly greater percent intrapair differences than the normal twins; i.e., their fingerprints were significantly less "twin-like."The study suggests that various second-trimester prenatal disturbances in the epigenesis of one twin in a pair discordant for schizophrenia may be related to the fact that only one of the twins expresses his or her genetic predisposition toward schizophrenia. This is consistent with a "two-strike" etiology of schizophrenia: a genetic diathesis plus a second-trimester environmental stressor.
Abstract 512: Fibroblasts Associated with Cardiac Fibrosis Carry Endothelial Imprint: Implication for Endothelial to Mesenchymal Transition
Authors: Elisabeth M Zeisberg, Oleg Tarnavski, Michael Zeisberg, Adam L Dorfman, Julie R McMullen, Erika Gustafsson, Anil Chandraker, Xueli Yuan, William T Pu, Mohamed H Sayegh, Seigo Izumo, Raghu Kalluri
Journal: Circulation (2006)
Abstract 10301: Disruption of Nitric Oxide Synthase 3 Potentiates Cardiac Dysfunction and Reduces Survival in Doxorubucin and Trastuzumab Mediated Cardiomyopathy
Authors: Matthew Zeglinski, Sheena Bohonis, Jordyn Lerner, Megan daSilva, Anita Sharma, James Thliveris, Pawan Singal, Davinder Jassal
Journal: Circulation (2011)