THE COMPARATIVE EFFECTIVENESS AND TOXICITY OF SULFATHIAZOLE AND SULFAPYRIDINE IN PNEUMOCOCCIC PNEUMONIA
Authors: Harrison F. Flippin, Leon Schwartz, S. Brandt Rose
Journal: Annals of Internal Medicine (1940)

Article1 May 1940THE COMPARATIVE EFFECTIVENESS AND TOXICITY OF SULFATHIAZOLE AND SULFAPYRIDINE IN PNEUMOCOCCIC PNEUMONIAHARRISON F. FLIPPIN, M.D., LEON SCHWARTZ, M.D., S. BRANDT ROSE, M.D.HARRISON F. FLIPPIN, M.D., LEON SCHWARTZ, M.D., S. BRANDT ROSE, M.D.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-13-11-2038 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptFollowing the discovery that sulfapyridine was an effective agent in treating experimental and clinical infections due to the pneumococcus, chemotherapy of pneumococcic pneumonia has received widespread attention during the past two years. Within this time numerous1 clinical reports unquestionably have established the therapeutic effectiveness of sulfapyridine in pneumonia. However, it is generally recognized that sulfapyridine therapy is not ideal because nausea and vomiting often interfere with adequate treatment. Furthermore, serious toxic manifestations, such as blood dyscrasias and renal complications, may occur.Within recent months there has become available a new sulfanilamide derivative, sulfathiazole,‡which we have used in the treatment...References1. EVANSGAISFORD GMWF: Treatment of pneumonia with 2-(p-aminobenzenesulfonamido) pyridine, Lancet, 1938, ii, 14. FLIPPIN, H. F., LOCKWOOD, J. S., PEPPER, D. S., and SCHWARTZ, L.: Treatment of pneumococcic pneumonia with sulfapyridine, Jr. Am. Med. Assoc., 1939, cxii, 529. AGRANAT, A. L., DREOSTI, A. O., and ORDMAN, D.: Treatment of pneumonia with 2-(p-aminobenzenesulfonamido) pyridine, Lancet, 1939, i, 309, 380. GRAHAM, D., WARNER, W. P., DAUPHINAE, J. A., and DICKSON, R. C.: Treatment of pneumococcic pneumonia with Dagenan, Canad. Med. Assoc. Jr., 1939, xl, 325. PLUMMER, N., and ENSWORTH, H.: Sulfapyridine in treatment of pneumonia, Jr. Am. Med. Assoc., 1939, cxiii, 1854. BULLOWA, J. G. M., OSGOOD, E. E., BUKANTZ, S. C., and BROWNLEE, I. E.: The effect of sulfapyridine alone and with serum on pneumococcic pneumonia and on pneumococcus-infected marrow cultures, Am. Jr. Med. Sci., 1940, cxcix, 364. CrossrefGoogle Scholar2. FOSBINDERWALTER RJLA: Sulfanilamido derivatives of heterocyclic amines, Jr. Am. Chem. Soc., 1939, lxi, 2032. CrossrefGoogle Scholar3. LOTTBERGEIM WAFH: 2-(p-aminobenzenesulfonamido) thiazole: a new chemotherapeutic agent, Jr. Am. Chem. Soc., 1939, lxi, 3593. CrossrefGoogle Scholar4. MCKEERAKEGREEPVAN DYKE CMGROHB: The therapeutic effect of sulfathiazole and sulfapyridine, Proc. Soc. Exper. Biol. and Med., 1939, xlii, 417. CrossrefGoogle Scholar5. VAN DYKEGREEPRAKEMCKEE HBROGCM: Observations on the pharmacology of sulfathiazole and sulfapyridine, Proc. Soc. Exper. Biol. and Med., 1939, xlii, 410. CrossrefGoogle Scholar6. REINHOLDFLIPPINSCHWARTZ JGHFL: Observations on the pharmacology and toxicology of sulfathiazole in man, Am. Jr. Med. Sci., 1940, cxcix, 393. CrossrefGoogle Scholar7. ANTOPOLROBINSON WH: Urolithiasis and renal pathology after oral administration of sulfapyridine, Proc. Soc. Exper. Biol. and Med., 1939, xl, 448. Google Scholar8. TSAOMCCRACKENCHENKUODALE YFMJPTCL: Renal complications in sulfapyridine therapy, Jr. Am. Med. Assoc., 1939, cxiii, 1316. CrossrefGoogle Scholar9. RAKEVAN DYKECORWINMCKEEGREEP GHBWCCMRO: Pathological changes following prolonged administration of sulfathiazole and sulfapyridine, Jr. Bact., 1940, xxxix, 45. Google Scholar10. SCHWARTZFLIPPINTURNBULL LHFWG: The treatment of pneumococcic pneumonia: a comparative study of 351 patients treated at the Philadelphia General Hospital, ANN. INT. MED., 1939, xiii, 1005. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Philadelphia, Pennsylvania*Read before the American College of Physicians, Cleveland, April 3, 1940.†With the collaboration of Jefferson H. Clark, M. D., and John G. Reinhold, Ph.D.From the Committee for the Study of Pneumonia, Philadelphia General Hospital.‡We are indebted to Dr. George A. Harrop, Squibb Institute for Medical Research, New Brunswick, New Jersey, for the sulfathiazole used in this study. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited bySulfonamide HematuriaKidney Complications during Sulphonamide Therapy1Zur Antipyretischen Wirkung von SulfonamidenSulfathiazole therapy in general surgeryPNEUMONIA TREATED WITH SULPHA- PYRIDINE AND SULPHATHIAZOLE CONCENTRATION OF THE DRUGS IN THE BLOODRENAL COMPLICATIONS OF SULPHAPYRIDINE THERAPYThe Treatment of Pulmonary Infections with Sulfanilamide, Sulfapyridine, and SulfathiazoleExperiences with Sulfathiazole in the Treatment of Gonorrhea in the MaleTreatment of furuncles, carbuncles and abscesses of staphylococcic origin with thiazole derivatives of sulfanilamideSulfathiazole and Sulfapyridine in the Treatment of Pneumococcal Pneumonia and Meningitis 1 May 1940Volume 13, Issue 11Page: 2038-2049KeywordsBloodChemotherapyNauseaPneumococcusPneumoniaToxicityVomiting Issue Published: 1 May 1940 PDF downloadLoading ...