tbuckley/cabot-search huggingface dataset:
An audit of the BMJ's correspondence columns.
Authors: R J Boyton, P C Arnold
Journal: BMJ (1990)

OBJECTIVE--To see whether some sections of the BMJ attract more comment than others, whether letters submitted in response to different sections of the journal are rejected at different rates, and whether the balance between letters that agree and disagree with articles in the published correspondence reflects that in submitted letters. DESIGN--Retrospective audit of letters submitted for publication in the correspondence columns of the BMJ in response to articles published between 1 January and 21 May 1989. SUBJECTS--A total of 1319 letters received by the journal, 974 submitted in response to the 1501 published articles and a further 345 raising new issues. MAIN OUTCOME MEASURES--The total numbers of letters submitted in response to the four main sections of the journal--editorials, news, papers, and middles--and the numbers published. Submitted and published letters were analysed according to whether they agreed or disagreed with articles. RESULTS--The overall rejection rate was 63% (831/1319), but among letters relating to articles it was 56% (543/974). Editorials and middles attracted proportionately more letters than papers, but letters relating to papers had a lower rejection rate (43% v 57% for editorials and 43% v 66% for middles). For all sections more letters disagreed than agreed, but a higher proportion of letters in response to editorials and middles disagreed than those submitted in response to papers (64% and 72% v 53%). Among the published letters, however, broadly equal numbers of letters agreed and disagreed with articles, irrespective of section. CONCLUSION--Those sections of the journal that aim at stimulating debate succeeded in attracting the most comment. The relative importance of original scientific research papers was reflected by the priority given to letters submitted in response to papers, and the final correspondence column was a balanced platform of debate despite an unequal submitted response in terms of letters that agreed and disagreed with different sections of the journal.
Good 'control' of diabetes yields more favorable lipid profile
Authors: E. R. Gonzalez
Journal: JAMA (1980)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Funduscopy: to dilate or not?: Other drugs can cause partial pupil dilatation
Authors: Peter D Cackett
Journal: BMJ (2006)

Editor—Liew et al highlight the very small risks associated with precipitating an attack of angle closure glaucoma when dilating a pupil for the purposes of funduscopy.1

The initiating event in acute angle closure glaucoma is incomplete mydriasis (pupil dilatation) resulting in pupil …
Gastrointestinal Contrast Agents
Authors: David J. Ott
Journal: JAMA (1983)

THE TWO major categories of contrast agents currently used to opacify the lumen of the gastrointestinal (GI) tract are barium sulfate suspensions and the iodinated water-soluble materials. Despite an extensive experience with these contrast media in the GI tract, confusion remains over their proper utilization. This article reviews the indications, uses, and risks of the commonly employed GI contrast agents. <h3>Barium Sulfate Suspensions</h3> Barium sulfate is almost totally inert within the GI tract, having little physiological effect other than responses to volume and fluidity.<sup>1</sup>Many commercial barium products are available for examining the GI tract; they vary widely in regard to density, viscosity, and ability to coat the mucosal surface. Many barium products have wide application throughout the GI tract, while others are specifically formulated for more limited use, such as double-contrast examination of the stomach or colon. Under most circumstances, barium sulfate suspensions are the preferred contrast materials
Prevention of autoantibody formation and prolonged survival in New Zealand black/New Zealand white F1 mice fed dehydroisoandrosterone.
Authors: J A Lucas, S A Ahmed, M L Casey, P C MacDonald
Journal: Journal of Clinical Investigation (1985)

Dehydroisoandrosterone, administered orally to New Zealand Black/New Zealand White F1 hybrid mice, prevented the formation of antibodies to double-stranded DNA and prolonged survival in this murine model of lupus erythematosus.
Serum cholesterol concentration and death from suicide in men: Paris prospective study I
Authors: M. Zureik, D. Courbon, P. Ducimetiere
Journal: BMJ (1996)

<h3>Abstract</h3> <b>Objective</b>: To investigate whether low serum cholesterol concentration or changing serum cholesterol concentration is associated with risk of suicide in men. <b>Design</b>: Cohort study with annual repeat measurements of serum cholesterol concentration (for up to four years). <b>Setting</b>: Paris, France. <b>Subjects</b>: 6393 working men, aged 43-52 in 1967-72, who had at least three measurements of serum cholesterol concentration. <b>Main outcome measures</b>: Individual change over time in serum cholesterol concentration (estimated using within person linear regression method); death from suicide during average of 17 years9 follow up after last examination. <b>Results</b>: 32 men committed suicide during follow up. After adjustment for age and other factors, relative risk of suicide for men with low average serum cholesterol concentration (&lt;4.78 mmol/l) compared with those with average serum cholesterol concentration of 4.78-6.21 mmol/l was 3.16 (95% confidence interval 1.38 to 7.22, P = 0.007). Men whose serum cholesterol concentration decreased by more than 0.13 mmol/l a year had multivariate adjusted relative risk of 2.17 (0.97 to 4.84, P = 0.056) compared with those whose cholesterol remained stable (change of &lt;/=0.13 mmol/l a year). <b>Conclusion</b>: Both low serum cholesterol concentration and declining cholesterol concentration were associated with increased risk of death from suicide in men. Although there is some evidence in favour of a concomitant rather than a causal effect for interpreting these associations, long term surveillance of subjects included in trials of lipid lowering treatments seems warranted. <h3>Key messages</h3> In this cohort study of 6393 men with repeated measurements of serum cholesterol concentration, both low serum concentrations and declining con- centrations was associated with increased risk of subsequent death from suicide Our results, together with those of recent trials of lipid lowering drugs, suggest that these associa- tions might not be causal However, long term surveillance of subjects included in trials of lipid lowering treatments seems warranted
Role of different dialysis membranes in the release of interleukin-6-soluble receptor in uremic patients
Authors: Bruno Memoli, Loredana Postiglione, Bruno Cianciaruso, Vincenzo Bisesti, Cristina Cimmaruta, Luigi Marzano, Roberto Minutolo, Vincenzo Cuomo, Brunella Guida, Michele Andreucci, Guido Rossi
Journal: Kidney International (2000)
TCT-706 The Influence of Mild Iatrogenic Mitral Valve Stenosis after Mitraclip(r) Implantation on Right Ventricular Function. Preliminary Data.
Authors: Marco Marzullo, Hannes Alessandrini, Christian Frerker, Thielsen Thomas, Peter Wohlmuth, Karl-Heinz Kuck, Ulrich Schäfer, Felix Kreidel
Journal: Journal of the American College of Cardiology (2013)
Outcome of the Treatment for Sarcoidosis: From the Authors
Authors: Gary W. Hunninghake, Chuck Dayton, Jeff Wilson, Connie Floerchinger, Jeff Galvin, David Schwartz
Journal: American Journal of Respiratory and Critical Care Medicine (1995)

"Outcome of the Treatment for Sarcoidosis: From the Authors." American Journal of Respiratory and Critical Care Medicine, 151(3_pt_1), pp. 920–921
Brucellosis in a Group of Travelers to Spain
Authors: Paul M. Arnow
Journal: JAMA (1984)

An epidemiologic investigation, initiated when<i>Brucella melitensis</i>infection was detected in a high school student, identified five unrecognized cases in classmates. Before the investigation, four infected students had symptoms of brucellosis for one to ten weeks, made nine visits to physicians, and were confined to the school infirmary or hospitals for 27 days. The other two students were asymptomatic when<i>Brucella agglutina-</i>tion testing demonstrated elevated titers, and treatment was quickly instituted when symptoms occurred. Travel to Spain was implicated because cases were clustered in six of 27 travelers compared with none of 23 control students. Food-history questionnaires showed more frequent consumption of cheese by infected than noninfected travelers. This cluster of cases demonstrates the risk of brucellosis in travelers to endemic areas and illustrates the value of an epidemiologic investigation of cases. (<i>JAMA</i>1984;251:505-507)
Disinfection By-products and Bladder Cancer: Common Genetic Variants May Confer Increased Risk
Authors: Kris S. Freeman
Journal: Environmental Health Perspectives (2010)

Genotoxicity of Chemicals in Indoor Swimming PoolsDisinfection by-products (DBPs) form in swimming pool water from reactions between disinfectants such as chlorine and organic matter such as sweat, skin cells, and urine.A new study described in a set of three articles provides the first comprehensive characterization of DBPs in an indoor pool environment and offers initial evidence of cellular-level effects of these chemicals in swimmers in an indoor chlorinated pool [
Lesson of the week: Unsuspected central hypothyroidism
Authors: A Waise
Journal: BMJ (2000)

Thyroid testing is increasingly used as a tool for identifying cases of thyroid disease in both primary and secondary care even in the absence of a strong clinical suspicion of disease. Patients with unsuspected thyroid disease are, therefore, likely to be identified, and among those identified are a few patients who have pituitary tumours or hypopituitarism. In the United Kingdom there is variation in which tests are offered for first line thyroid testing. In a 1994 survey of endocrinological testing in clinical biochemistry laboratories in the United Kingdom, Barth et al found that 30 different combinations of first line and second line profiles were being used.1 In a total of 186 replies 34% of laboratories reported offering testing for free thyroxine concentrations and thyroid stimulating hormone, 32% offered testing only for thyroid stimulating hormone, and 18% offered testing for total thyroxine concentration. The cases of the six patients described here highlight the fact that offering testing only for thyroid stimulating hormone (TSH) may be inappropriate.

The first five patients discussed had concentrations of free thyroxine hormone and thyroid stimulating hormone measured using a highly sensitive, third generation method (Amerlite hTSH, Kodak Clinical Diagnostics, Amersham). In the sixth patient these were measured by a two step, second generation method (Beckman Instruments, High Wycombe). Prolactin, luteinising hormone, and follicle stimulating hormone were measured using the Abbott IMX fluoroimmunoassay (Abbott Diagnostics, Maidenhead). Growth hormone was measured using the Nichols Diagnostics immunoassay (Nichols Institute Diagnostika, Bad-Nauheim, Germany). Testosterone was measured by radioimmunoassay. Anterior pituitary function was investigated in five patients using glucagon, thyrotrophin releasing hormone, and gonadotrophin releasing hormone challenge. Insulin was used instead of glucagon in one instance.

### Case 1

A 75 year old man with a three year history of anaemia was referred by his general practitioner to a general physician. The patient's …
The Urban Condition; People and Policy in the Metropolis.
Authors: Marjorie C. Meehan
Journal: JAMA (1963)

Since we are recognizing more and more the relationship between mental health and environment, and since the majority of Americans now live in metropolitan areas, a study of urban problems is clearly relevant to mental health problems. This book is one product of the long-range interdisciplinary study of varied aspects of city life, sponsored by the National Institute of Mental Health. Only a few of the authors are physicians, but they all—biologists, political scientists, lawyers, and even a landscape architect—have something to offer the physician who seeks to understand how the problems of urban living affect his patients. Although the 29 diverse papers cover a wide range, from the feelings of Puerto Rican slum dwellers about their homes to the behavior of rats in crowded cages, and from case histories to theoretical discussions of simulated models, there is a basic unity of attitude and goal. The authors have worked and
Unity amidst heterogeneity in theories of concepts
Authors: Kevan Edwards
Journal: Behavioral and Brain Sciences (2010)

Abstract This commentary raises two concerns with Machery's approach in Doing without Concepts. The first concern is that it may be possible to preserve a unified theory of concepts by distinguishing facts about concept individuation from facts about cognitive structures and processes. The second concern questions the sharpness of the distinction Machery draws between psychological and philosophical conceptions of concepts.
Decision-Making in Oncology
Authors: Jacob D. Bitran
Journal: JAMA (1990)

<i>Decision-Making in Oncology</i>is a unique textbook unlike any oncology text currently in publication. It is not a comprehensive textbook of oncology, and the editor makes no such claims. The aim of the text is "to provide practical guidance to the physician who is faced with the task of choosing an appropriate treatment program." In pursuit of this aim, each chapter provides in an easily followed diagrammatic format, a series of algorithms or branching decision trees based on the acquisition of clinical data. These algorithms are the major strength of this text. They help the reader visualize the impact of clinical information on the decision-making process and how it ultimately impacts on overall therapy. The accompanying text of the individual chapters is easy to read, clear, concise, and up-to-date. With the recognition that this book is a supplement to any standard oncology text, I believe that it would be a
Survival of Transfused Donor Mononuclear Leukocytes during Open-Heart Surgery
Authors: Robert G. Scherz, Robert C. Montgomery
Journal: New England Journal of Medicine (1963)

IN 1962 Petrakis and Politis,1 utilizing tissue-culture methods, demonstrated that certain mononuclear leukocytes remained viable in stored human blood for as long as twenty-two days, with no significant change in viability for as long as twenty-four hours. It follows that donor mononuclear leukocytes are viable at the time of transfusion of short-term stored blood to the recipients. Recently, Seaman and Starr2 described a new entity, designated as "febrile post cardiotomy lymphocytic splenomegaly," occurring after open-heart surgery with the pump oxygenator, in which massive transfusions of fresh whole blood are employed. In 9 of 250 patients a typical syndrome of fever, . . .
Abstract 5247: Comprehensive and systematic identification of miR-215 targets in colon cancer via a novel translation capture immunoprecipitation (TrIP) approach
Authors: Andrew Fesler, Xiao Xu, Emily Chen, Jingfang Ju
Journal: Cancer Research (2014)

Abstract The important roles that non-coding miRNAs play in cancer development, makes the investigation of the various genes they target particularly crucial. In addition to targeting mRNA transcripts for degradation, miRNA can also alter gene expression at the translational level to achieve rapid regulation. It has been a technical challenge to study translational control using a small number of cells. We have overcome this hurdle by developing a translational capture immunoprecipitation approach (TrIP) to investigate RNA binding proteins or non-coding RNA regulation at the translational level from a small numbers of cells. The new approach is based on the fact that nascent translated polypeptides are associated with hsp70 chaperones along with actively translating mRNA transcript complexes, called polyribosomes. We are able to isolate actively translating mRNA from free cytoplasmic mRNA by immunoprecipitation of hsp70 associated polyribosome complexes. In this study, we utilize this novel approach to identify both degraded and non-degraded mRNA transcripts targeted by miR-215 in colon cancer. Following miR-215 overexpression in colon cancer cells, actively translating mRNA transcripts were isolated using the TrIP technique and purified following standard RNA isolation techniques. We were able to identify additional non-degraded mRNA targets regulated by miR-215 using a TrIP with transcriptome-wide microarray based approach, when compared to a generic approach based on steady state total RNA that can only identify degraded targets. Specific targets were independently validated using qRT-PCR analysis. We further validated miR-215 targets at the protein level with a comprehensive and high-throughput quantitative SILAC proteomics analysis. Protein targets were further validated using Western blotting with select positive control targets including TYMS, DTL and DHFR. This approach offers the unique opportunity to understand not only the mRNA targets a miRNA may target for degradation, but also those it regulates at the translational level, providing unique insight into the actions of miRNAs. Interest in this type of thorough analysis of different miRNAs or RNA binding proteins will likely continue to grow as the important roles miRNA play in cancer are further investigated. Citation Format: Andrew Fesler, Xiao Xu, Emily Chen, Jingfang Ju. Comprehensive and systematic identification of miR-215 targets in colon cancer via a novel translation capture immunoprecipitation (TrIP) approach. [abstract]. In: Proceedings of the 105th Annual Meeting of the American Association for Cancer Research; 2014 Apr 5-9; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2014;74(19 Suppl):Abstract nr 5247. doi:10.1158/1538-7445.AM2014-5247
Function of CD4+CD3− cells in relation to B- and T-zone stroma in spleen
Authors: Mi-Yeon Kim, Fiona M. McConnell, Fabrina M. C. Gaspal, Andrea White, Stephanie H. Glanville, Vasilios Bekiaris, Lucy S. K. Walker, Jorge Caamano, Eric Jenkinson, Graham Anderson, Peter J. L. Lane
Journal: Blood (2006)
Microbial exposure of rural school children, as assessed by levels of N-acetyl-muramic acid in mattress dust, and its association with respiratory health☆
Authors: Robert Theodoor van Strien, Regina Engel, Otto Holst, Albrecht Bufe, Waltraud Eder, Marco Waser, Charlotte Braun-Fahrländer, Josef Riedler, Dennis Nowak, Erika von Mutius
Journal: Journal of Allergy and Clinical Immunology (2004)
Follow-up of Bronchial Precancerous Lesions and Carcinoma <i>in Situ</i> Using Fluorescence Endoscopy
Authors: SUZANA BOTA, JEAN-BERNARD AULIAC, CHRISTOPHE PARIS, JOSETTE MÉTAYER, RICHARD SESBOÜÉ, GEORGES NOUVET, LUC THIBERVILLE
Journal: American Journal of Respiratory and Critical Care Medicine (2001)

Little is known about the natural history of precancerous bronchial lesions. Histological changes occurring in 416 bronchial intraepithelial lesions (104 high-risk subjects) were assessed over a 2-yr period, using repeated follow-up autofluorescence endoscopies. During the study, 6 of 36 normal epitheliums became dysplastic; 47 of 152 metaplasia evolved to low-grade dysplasia, two progressed to carcinoma in situ, and one to invasive cancer; 6 of 169 low-grade epithelial lesions progressed to a persistent severe dysplasia; 10 of 27 severe dysplastic lesions and 28 of 32 carcinoma in situ persisted or progressed, respectively (p = 0.0005, severe dysplasia versus carcinoma in situ 24 mo outcome). Carcinoma in situ appeared more frequent in patients with a prior history or concomitant cancer (p = 0.003). Persistence of smoking during the study did not influence high-grade lesion outcome. Progression of low-grade epithelial lesions during the study occurred only in patients with at least a high-grade lesion in another site at baseline (9 of 147 lesions, 6.1%). Our study suggests that low-grade epithelial lesions could be safely followed-up at 2 yr in patients without high-grade lesions at baseline, whereas severe dysplasia should be treated if they persist at 3 mo. Immediate treatment of carcinoma in situ appears warranted.
Demonstration of a Radionuclide Pattern in Pheochromocytomas in Children
Authors: JOHN R. STY, ROBERT J. STARSHAK, KUMUDCHANDRA J. SHETH
Journal: Clinical Nuclear Medicine (1978)

Scintigraphic findings in a child with pheochromocytomas is illustrated. The patient demonstrated a hypervascular lesion during the radionuclide angiogram, and renal displacement on subsequent static images.
Differential long-term intrarenal and neurohormonal effects of captopril and prazosin in patients with chronic congestive heart failure: importance of initial plasma renin activity.
Authors: B Mettauer, J L Rouleau, D Bichet, C Kortas, C Manzini, G Tremblay, K Chatterjee
Journal: Circulation (1986)

Fifty patients with congestive heart failure received, by infusion, 15 ml/kg body weight water load, and systemic hemodynamic, renal function, and neurohumoral parameters values were measured before, 2 days, and 1 month after randomly allocating patients to prazosin or captopril therapy. Both prazosin and captopril caused similar and persistent hemodynamic changes, but important differences existed between their renal and neurohumoral effects. After 1 month of continuous therapy, captopril increased creatinine clearance from 71 to 84 ml/min/1.73(2) (p less than .05), increased the water load excreted in 5 hr from 50% to 71% (p less than .005), and increased 5 hr sodium excreted from 6.8 to 14.7 meq (p less than .005), Captopril also caused a decrease in plasma norepinephrine from 568 to 448 pg/ml (p less than .005), in plasma epinephrine from 94 to 73 pg/ml (p less than .05), and in plasma aldosterone from 57 to 28 ng/dl (p less than .005), without changing plasma vasopressin. These beneficial effects were greater after 1 month of therapy than after 2 days. The only beneficial effect of prazosin was to increase water excretion from 49% to 59% (p less than .05). The long-term response to captopril was similar in patients with higher (greater than 2.5 ng/ml/hr) and lower renin levels. However, in patients with lower renin levels, prazosin decreased pulmonary capillary wedge pressure (24.8 to 21.8 mm Hg, p less than .05), decreased plasma arginine vasopressin (1.16 to 0.75 pg/ml, p less than .05), increased water excretion (62% to 85%, p less than .005), and decreased plasma epinephrine (81 to 46 pg/ml, p less than .05), while in patients with higher renin levels none of these beneficial effects were noted. We conclude that captopril produces long-term beneficial renal and neurohumoral effects that prazosin does not despite similar hemodynamic changes with the two drugs, that these effects are at least partially dependent on the initial neurohumoral and hemodynamic status of the patient, and that through hemodynamic improvement vasodilators may chronically interrupt vasopressin overstimulation.