Age-Adjusted Standards for Creatinine Clearance
Authors: JOHN W. ROWE
Journal: Annals of Internal Medicine (1976)

Letters1 May 1976Age-Adjusted Standards for Creatinine ClearanceJOHN W. ROWE, M.D., REUBIN ANDRES, M.D., JORDAN D. TOBIN, M.D., ARTHUR H. NORRIS, M.S., NATHAN W. SHOCK, PH.D.JOHN W. ROWE, M.D.Search for more papers by this author, REUBIN ANDRES, M.D.Search for more papers by this author, JORDAN D. TOBIN, M.D.Search for more papers by this author, ARTHUR H. NORRIS, M.S.Search for more papers by this author, NATHAN W. SHOCK, PH.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-84-5-567 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptGlomerular filtration rate (GFR) has been shown to decline with age after maturity (1). Creatinine clearance finds frequent use as a clinical estimate of GFR, and published criteria for severity of renal disease include classification of patients according to their creatinine clearance as compared with the "predicted normal" (2). In spite of this recommendation, no satisfactory age-adjusted normal standards for creatinine clearance are currently available. The present study was done in order to provide such standards.Standard 24-h creatinine clearance measurements were done on 884 adult male subjects (17 to 96 years) in the Baltimore Longitudinal Study of Aging (3)....References1. WESSON L: Renal hemodynamics in physiological states, in Physiology of the Human Kidney, edited in WESSON LG JR, New York, Grune and Stratton, 1969, p. 96 Google Scholar2. : Criteria for the evaluation of the severity of established renal disease. Ann Intern Med 75:251-252, 1971 LinkGoogle Scholar3. STONENORRIS JA: Activities and attitudes of participants in the Baltimore Longitudinal Study. J Gerontol 21:575-580, 1966 CrossrefMedlineGoogle Scholar4. HEALY J: Clinical assessment of glomerular filtration rate by different forms of creatinine clearance and a modified urinary phenolsulphonphthalein excretion test. Am J Med 44:348-358, 1968 CrossrefMedlineGoogle Scholar5. SIERSBAEK-NIELSENMOLHOLM HANSENKAMPMANN KJJ: Rapid evaluation of creatinine clearance. Lancet 1:1133-1134, 1971 CrossrefMedlineGoogle Scholar6. GAULCOCKCROFT MD: Creatinine clearance and age. Lancet 2:613-614, 1975 Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: JOHN W. ROWE, M.D.; REUBIN ANDRES, M.D.; JORDAN D. TOBIN, M.D.; ARTHUR H. NORRIS, M.S.; NATHAN W. SHOCK, PH.D.Affiliations: Clinical Physiology Branch Gerontology Research Center National Institute on Aging National Institutes of Health at the Baltimore City Hospitals Baltimore, MD 21224 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byPrevalence of chronic kidney diseases and its determinants among Iranian adults: results of the first phase of Shahedieh cohort studyBeyond pigmentation: signs of liver protection during afamelanotide treatment in Swiss patients with erythropoietic protoporphyria, an observational studyMeasurement and Estimation of Kidney FunctionGlomerular filtration rate: new age- and gender- specific reference ranges and thresholds for living kidney donationGlomerular filtration rate equations: a comprehensive reviewRisk Score for the Prediction of Contrast-Induced Nephropathy in Elderly Patients Undergoing Percutaneous Coronary InterventionChapter 1: Definition and classification of CKDReferencesGlyoxalase I Retards Renal SenescenceMeasurement and Estimation of Kidney FunctionDrug–Nutrient Interactions in the ElderlyMétabolisme de l’eau et besoins hydriques de la personne âgéeEndogenous sodium pump inhibitors and age-associated increases in salt sensitivity of blood pressure in normotensivesKIDNEY IN OLD AGERenal ageingThe Aging Kidney: A Review – Part IMechanistic basis of adverse drugreactions: the perils of inappropriate dose schedulesDrug development and use in the elderly: search for the right dose and dosing regimenEpilepsie im AlterACE Inhibitor and Postoperative Renal DysfunctionAccuracy of Short-Duration Creatinine Clearance Determinations in Predicting 24-Hour Creatinine Clearance in Critically Ill and Injured PatientsACE Inhibitor and Postoperative Renal DysfunctionThe Ageing Lower Urinary TractRenal function and renal disease in the elderly:Folate Status of Elderly Women following Moderate Folate Depletion Responds Only to a Higher Folate IntakeDevelopment of a knowledge-base for automatic monitoring of renal function of intensive care patients over timeRenal involvement in primary Sjögren's syndromeHemodialysis in Elderly PatientsIntroduction: Aging and the KidneyLong-term evolution of renal function in patients with ovarian cancer after whole abdominal irradiation with or without preceding cisplatinUrinary nickel excretion in populations living in the proximity of two russian nickel refineries: a Norwegian-Russian population-based study.Human Nickel Exposure in an Area Polluted by Nickel Refining: The S⊘r-Varanger StudyThe measurement of urinary amino-terminal telopeptides of type I collagen to monitor bone resorption in patients with primary hyperparathyroidismHyperkalemia in the elderlyRenal function in the elderly: Impact of hypertension and cardiac functionThe Effect of Age on the Cardiovascular Response to StressAnalysis of Various Creatinine Clearance Formulas in Predicting Gentamicin Elimination in Patients With Low Serum CreatininePrevalence of chronic hypokalaemia amongst elderly patients using acetozolamide and diureticsRenal sodium excretion in normal aging: Decreased excretion rates lead to delayed handling of sodium loadsPHARMACOLOGIC CONSIDERATIONS IN GERIATRIC DENTISTRYTrauma in Patients with Pre-Existing Cardiac DiseasePre-Existing Peripheral Arterial Disease in TraumaAbnormalities of Renal Physiology in Systemic SclerosisReduced Renal Hemodynamic Response to Atrial Natriuretic Peptide in Elderly VolunteersDivergent hemodynamic and hormonal responses to varying salt intake in normotensive subjects.Measured versus Estimated Creatinine Clearance in a High-Functioning Elderly Sample: MacArthur Foundation Study of Successful AgingRenal function and fluid-electrolyte homeostasis changes with ageAssessment of Renal Function—Glomerular and TubularThe ageing process1. 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PYERITZ, M.D., PH.D.The Ageing Lower Urinary Tract 1 May 1976Volume 84, Issue 5Page: 567-569KeywordsAgingCreatinineGlomerular filtration rateLongitudinal studiesRenal diseases ePublished: 1 December 2008 Issue Published: 1 May 1976 PDF downloadLoading ...