tbuckley/cabot-search huggingface dataset:
EPIDEMIC SYPHILIS, ITS RECOGNITION AND MANAGEMENT BY THE PHYSICIAN
Authors: E. Gurney Clark
Journal: Annals of Internal Medicine (1939)

Article1 August 1939EPIDEMIC SYPHILIS, ITS RECOGNITION AND MANAGEMENT BY THE PHYSICIANE. GURNEY CLARK, M.D.E. GURNEY CLARK, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-13-2-238 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptINTRODUCTIONSyphilis exhibits many of the characteristics of epidemic disease. It has the capacity of producing a sharp increase in incidence in a short time.1 It often gives rise to localized outbreaks; and, in at least one historic instance, it appeared as a sudden outbreak over a wide area. This concept with regard to syphilis is not a new one. More than 100 reports of localized epidemics of syphilis can be found in the literature under titles which imply epidemicity.The mild character or total absence of the early manifestations; the "conspiracy of silence" with regard to the disease; and...Bibliography1. GILL AG: The genesis of epidemics, 1928, William Wood and Co., New York, Chapter I. Google Scholar2. CLARK EG: Results of contact investigation in a University Hospital syphilis clinic. To be published. Google Scholar3. PAUL JR: Clinical epidemiology. President's Address, Jr. Clin. Invest., 1938, xvii, 539. CrossrefGoogle Scholar4. NELSON NA: Syphilis looks at the doctor, New England Jr. Med., 1937, ccxvii, 971. CrossrefGoogle Scholar5. STOKES JH: Cutaneous and mucosal relapse in early syphilis and its differentiation from reinfection, Ven. Dis. Inform., 1931, xii, 55. Google Scholar6. HELLERSMITH JRDC: Proper epidemiological approach in early cases of syphilis decreases treatment delinquency, Indian Jr. Ven. Dis., 1937, iii, 155. Google Scholar7. EXNER MJ: The value of instructing the syphilis patient, Ven. Dis. Inform., 1935, xvi, 59. Google Scholar8. CLARK EG: Patient instruction in controlling infectiousness of patients with early syphilis. To be published. Google Scholar9. NELSON NA: The follow up of gonorrhea and syphilis in private practice, New England Jr. Med., 1933, ccviii, 1153. CrossrefGoogle Scholar10. INGRAHAM NR: Contact tracing and case holding in New Jersey, Ven. Dis. Inform., 1938, xvix, 61. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: *Read at the New Orleans meeting of the American College of Physicians, March 29, 1939.From the Department of Medicine, Vanderbilt University School of Medicine.The epidemiological investigations were made possible through funds granted by the United States Public Health Service. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited bySyphilisThe Importance of Contact Investigation in the Control of Syphilis 1 August 1939Volume 13, Issue 2Page: 238-247KeywordsMedical servicesSyphilis Issue Published: 1 August 1939 PDF downloadLoading ...
Short- and Long-Term Risk Stratification in Acute Coronary Syndromes
Authors: Cynthia M. Westerhout, Yuling Fu, Michael S. Lauer, Stefan James, Paul W. Armstrong, Eyad Al-Hattab, Robert M. Califf, Maarten L. Simoons, Lars Wallentin, Eric Boersma
Journal: Journal of the American College of Cardiology (2006)
Systemic sclerosis immunoglobulin G autoantibodies bind the human cytomegalovirus late protein UL94 and induce apoptosis in human endothelial cells
Authors: Claudio Lunardi, Caterina Bason, Riccardo Navone, Enrico Millo, Gianluca Damonte, Roberto Corrocher, Antonio Puccetti
Journal: Nature Medicine (2000)
Lifelong Care for PKU
Authors: Joan Stephenson
Journal: JAMA (2000)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
<scp>ABCG</scp>2 overexpression in patients with acute myeloid leukemia: Impact on stem cell transplantation outcome
Authors: Daniela Damiani, Mario Tiribelli, Antonella Geromin, Angela Michelutti, Margherita Cavallin, Alessandra Sperotto, Renato Fanin
Journal: American Journal of Hematology (2015)

ABGG2 protein overexpression in acute myeloid leukemia (AML) has been associated with poor response to conventional chemotherapy and increased relapse risk. No data are available on the role of allogeneic stem cell transplantation (SCT) in reversing its negative prognostic role. We have reviewed the outcome of 142 patients with high risk AML who underwent allogeneic SCT in complete remission (n = 94) or with active disease (n = 48). Patients with ABCG2 overexpression at AML diagnosis have lower leukemia free survival (LFS) and increased cumulative incidence of relapse (CIR) compared with ABCG2- patients (5-year LFS 50% vs. 65%, P = 0.01; 5-year CIR 46% vs. 27%, P = 0.003). Five-year overall survival was not significantly different between ABCG2+ and ABCG2- patients (39% vs. 51%, P = 0.1). However, if we consider only disease-related deaths, ABCG2 maintains its negative role (64% vs. 78%, P = 0.018). The negative impact of ABCG2 overexpression was higher in patients undergoing SCT in CR compared with patients receiving transplant with active disease. Conditioning regimen did not abrogate the effect of ABCG2 overexpression, as CIR was higher in ABCG2+ patients receiving both myeloablative (44% vs. 22%, P = 0.018) or reduced intensity conditioning (50% vs. 32%, P = 0.03). In conclusion, ABCG2 overexpression at AML diagnosis identifies a subset of patients with poor outcome also after allogeneic SCT, mainly in terms of higher relapse rates. Prospective studies employing conditioning drugs or post-transplant strategies able to target ABCG2 are needed to maximize the curative potential of stem cell transplantation.
Lehrbuch Der Augenheilkunde.
Authors: Ernst Fuchs
Journal: Annals of Internal Medicine (1940)

chapter are particularly excellent and useful. The second volume will include the literature beginning January 1944, and ending in June 1946. The book making is excellent, with good paper and distinct type. The author and his co-editors are to be congratulated on the successful outcome of this volume. The second volume, on its appearance in 1947, will complete a most useful and excellent summary of ophthalmologic literature of a part of the world during the war years.
Abstract 20411: Depression Screening and Case-Finding Tools in Heart Failure: Timing Matters
Authors: Teresita Corvera-Tindel, Lynn V Doering
Journal: Circulation (2014)

Depression in HF is associated with noncompliance to treatment recommendations, reduced health status and quality of life, and increased hospital readmission and mortality. Early and accurate screening and case-finding for depression in HF patient is critical. The purpose of this study was to evaluate the performance of common depression screening tools in HF patients in both acute or outpatient setting. Methods: At hospital admission, 118 veterans (99% male, 68 ± 10 years) were evaluated for clinical depression; 96 were tested again at 6 months. At both times, 3 screening tools (Beck Depression Inventory [BCI], Patient Health Questionnaire [PHQ]-2, and PHQ-9) were completed. Clinical depression was measured by the Diagnostic Interview Structured Hamilton (DISH) administered by trained nurses. Performance of each tool was evaluated with receiver operating characteristics (ROC) analysis and calculation of sensitivity, specificity, and positive predictive value (PPV). Results: In hospital and 6 months later as outpatients, 24 (20.3%) and 14 (14.6%) veterans exhibited clinical depression, respectively. For all 3 tools, area under the curve values were significant (Table). At hospitalization, cut-off scores above those normally suggested provided superior sensitivity, specificity and PPV. For screening with high cut-offs, the BDI and PHQ-9 yield acceptable sensitivity. For case-finding, the BDI exhibited acceptable PPV at a high cut-off. At 6 months, optimal cut-offs all 3 tools approached those normally suggested, with the PHQ-2 yielding a stronger PPV than the BDI or PHQ-9. Conclusion: While all 3 tools were useful for depression screening and case-finding in HF, timing relative to hospital admission influences performance. While the BDI works well for screening and case-finding, the PHQ-9 performs better for screening at hospital admission and the PHQ-2 performs better for case-finding 6 months after admission.
Off-Pump or On-Pump Coronary-Artery Bypass Grafting
Authors: André Lamy, P J Devereaux, Salim Yusuf
Journal: New England Journal of Medicine (2013)

Coronary-Artery Bypass GraftingTo the Editor: In the CABG Off or On Pump Revascularization Study (CORONARY) described by Lamy et al. (March 28 issue), 1 the investigators used the approach of an expertise-based, randomized, controlled trial. 2 The qualified surgeons were those with more than 2 years of experience after residency training who had completed more than 100 cases of the specific technique.Lamy and colleagues also emphasized that "trainees were not allowed to be the primary surgeon."But the authors do not specify who harvested saphenous-vein grafts.In many centers, trainees are the primary surgeons for this procedure.Graft harvesting is an important part of the coronaryartery bypass grafting (CABG) operation.One study showed that rates of vein-graft failure were higher among patients with poor-quality grafts, and vein-graft failure was associated with repeat revascularization. 3
Online Empathy for Mood Disorders
Authors: Lynne Lamberg
Journal: JAMA (2003)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Neuroleptic use, parkinsonian symptoms, tardive dyskinesia, and associated factors in child and adolescent psychiatric patients
Authors: M A Richardson, G Haugland, T J Craig
Journal: American Journal of Psychiatry (1991)

The authors' goal was to determine the prevalence of and risk factors for neuroleptic-induced movement disorders in a group of psychiatrically hospitalized children and adolescents.They evaluated the presence or absence of parkinsonism, tardive dyskinesia, and akathisia in 104 children and adolescents who were in residence in or admitted over a 6-month period to a state-operated child psychiatric center. They applied a standardized, structured assessment procedure used in research on adult and geriatric psychiatric patients and the mentally retarded.The prevalence of parkinsonism among the 61 subjects at risk was 34% and was significantly associated with longer neuroleptic treatment periods immediately before evaluation. The prevalence of treatment-emergent tardive dyskinesia among the 41 subjects at risk was 12% and showed no association with quantitative neuroleptic treatment variables. However, patients with tardive dyskinesia were significantly more likely to have a family history of mental illness and significantly less likely to have a history of assaultive behavior. A pattern of complex pharmacological responses for parkinsonism and tardive dyskinesia, some of which are not typical of those most commonly reported in adults, was seen in this group of young patients.The study data highlight the acute sensitivity of the neuroleptic-treated child and adolescent to the development of parkinsonism, the possible role of certain patient characteristics in the vulnerability to develop tardive dyskinesia, and the possibility that neuroleptic-induced side effects experienced by children and adolescents differ in some ways from those experienced by adults. The data further strongly support the need for systematic monitoring of neuroleptic-treated child and adolescent patients for a full range of side effects.
Serum hepatitis B virus RNA levels as an early predictor of hepatitis B envelope antigen seroconversion during treatment with polymerase inhibitors
Authors: Florian van Bömmel, Anne Bartens, Alena Mysickova, Jörg Hofmann, Detlev H. Krüger, Thomas Berg, Anke Edelmann
Journal: Hepatology (2014)

Hepatitis B envelope antigen (HBeAg) seroconversion represents an endpoint of treatment of chronic hepatitis B virus (HBV) infections. We have studied whether levels of serum HBV RNA during polymerase inhibitor treatment might be helpful for predicting HBeAg seroconversion. HBV RNA levels were determined in serial serum samples from 62 patients with chronic HBV infection (50 HBeAg positive). Patients received antiviral treatment for a mean duration of 30 ± 15 (range, 4-64) months. A new rapid amplification of complimentary DNA-ends-based real-time polymerase chain reaction was established for quantitative analysis of polyadenylated full-length (fl) and truncated (tr) HBV RNA. HBV RNA, HBV DNA, and hepatitis B surface antigen (HBsAg) levels as well as presence of HBeAg and hepatitis B envelope antibody were measured at baseline, month 3, month 6, and subsequent time points. Fifteen patients who achieved HBeAg seroconversion after a mean duration of 19 ± 14 (range, 3-56) months of antiviral treatment showed a significantly stronger decline in mean HBV flRNA and trRNA levels from baseline to month 3 of 1.0 ± 1.4 (range, -1.6-3.4) and 2.1 ± 1.4 (range, 0-3.9) and to month 6 of 1.8 ± 1.4 (range, 0-4.6) and 3.1 ± 1.7 (range, 0-5.1) log10 copies/mL, respectively, in comparison to 35 HBeAg-positive patients without HBeAg seroconversion (P < 0.001 for months 3 and 6). A similar decline in HBV RNA levels was observed in HBeAg-negative patients. The decline of HBV RNA levels at months 3 and 6 of treatment was to be the strongest predictor of HBeAg seroconversion, when compared to levels of HBV DNA, HBsAg, alanine aminotransferase, and HBV genotype, age, and sex.Serum HBV RNA levels may serve as a novel tool for prediction of serological response during polymerase inhibitor treatment in HBeAg-positive patients.
Diabetes Awareness Campaign
Authors: Joan Stephenson
Journal: JAMA (1998)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Clinical and Dermoscopic Features of Cutaneous Melanoacanthoma
Authors: Esther Chung, Ashfaq A. Marghoob, Cristina Carrera, Michael A. Marchetti
Journal: JAMA Dermatology (2015)

This review of previously acquired data reports that the use of a 2-step algorithm and pattern analysis in dermoscopy can identify benign cutaneous melanoacanthoma in patients with seborrheic keratosis.
Development of Orthogonal Multiplex Gene-Switch Systems Based on Engineered Ecdysone Receptors and Inducing Ligands Selected from a Single Chemotype
Authors: Jennifer L. Friz, Beth Vertin, Christine S. Thompson, Subba R. Palli, Mohan Kuman, Orestes Chortyk, Andy Meyer, Tom Meteyer, Howard Smith, Robert E. Hormann, Dean E. Cress
Journal: Molecular Therapy (2004)

Drug-inducible regulation of multiple genes independently and simultaneously is a highly desirable gene therapy capability. Actuation of a plurality of genes with members of a common chemotype, rather than several unrelated chemotypes, could provide advantages in simplifying pharmacokinetics and pharmacodynamics, and could also potentially ameliorate possible undesired pleiotropic effects. Toward the goal of an orthogonal multiplex gene-switch using a single chemotype, a designed library of ca. 150 diacylhydrazine ligands was screened against a panel of ca. 50 wild-type and mutant ecdysone receptors (EcR) in a transcriptional activation assay using the EcRs fused to the GAL4 DNA binding domain in conjunction with a chimeric RXR fused to a VP16 activation domain. Luciferase was employed as a reporter gene, and the vectors were transfected into 3T3 cells. EC50 values for each receptor-ligand pair were obtained and multiple robust two-channel orthogonalities were observed. Structure activity relationships of both ligands and receptors are statistically meaningful and can be understood in the classical terms of medicinal chemistry.
Observations on the Antiproteolytic Reaction of the Serum of Mice: Strain Variations
Authors: Eugene E. Cliffton, Daniel W. Elliott, Walter J. Nero
Journal: Cancer Research (1949)

Summary  1.A method for determining the antiproteolytic activity of serum of mice is described.  2.Variations have been found in the antiproteolytic activity of the serum in several strains of mice.  3.The possible correlation between these variations and susceptibility to tumor formation is discussed.
More on wives
Authors: Trisha Greenhalgh
Journal: BMJ (2001)

Thanks to the 24 people (including two from the BMJ 's editorial office) who applied for the job of my wife ( BMJ 2000;321:1421). Thanks, too, to the (female) consultant surgeon who wrote in asking for names of any promising applicants that I didn't appoint.

The job's gone, to a fine individual from a former Soviet bloc country whom the agency described as “a most mature, most experienced lady.” Indeed she is, and for an embarrassingly small sum she cooks, cleans, keeps house, and …
Abstract 13650: Microrna Signatures in the Transition From Left Ventricular Hypertrophy to Cardiac Dysfunction
Authors: Melissa Swinnen, Hadewich Hermans, Mattia Quattrocelli, Peter Pokreisz, Hilde Gillijns, Ellen Caluwé, Kenneth Block, Stefan Janssens
Journal: Circulation (2014)

Purpose: Left ventricular hypertrophy (LVH) is not just a compensatory response to increased biomechanical stress but is often associated with unfavorable outcome in patients. Mechanisms that govern transition from subclinical LVH to LV dysfunction are incompletely understood. Lately, single microRNAs (miRs), a class of small non-coding RNAs, have been implicated in LVH, but the expression dynamics and their role in transition to LV dysfunction remain unknown. Methods: We subjected mice to transverse aortic constriction (TAC) for 2, 4 and 10 weeks(wks) or to Ang-2 infusion for 4wks. Cardiac function was examined using serial echocardiography (TTE) and compared to sham mice (SH). MiR profiles in LV tissue were studied using the Nanostring platform, with significant differences between TAC or Ang2 vs SH set at a &gt;2 up-or down-regulation with p&lt;0.01. Western blotting and luciferase assay were performed for target confirmation. The impact of up-regulated miRs was validated in vivo by administration of specific AntagomiR vs Scrambled miRs (SCR) after TAC. Results-TTE showed a modest increase in LV end-systolic dimensions and a decline in fractional shortening (FS) after 4wks TAC and Ang2 . However, after 10wks TAC, LV dilation was present together with a reduction in FS (table1). Cardiac miR signatures indicated that 3 miRs were selectively up-regulated when transition to LV dysfunction was present at 10wks TAC. A common target gene for 2 of these up-regulated miRs (miR764-3p and miR-130b-3p) was confirmed. Moreover, in vivo antagomiR treatment for both miRs protected against cardiac dysfunction and fibrosis(table 1). Conclusion: miR analyses show important time- and stressor-dependent dynamic expression patterns during pressure overload. The miR signatures associated with transition from LVH to LV dysfunction and subsequent targeted antagomiR administration may hold promise for future therapy.