tbuckley/cabot-search huggingface dataset:
Trends of HIV seroconversion among young adults in the US Army, 1985 to 1989. US Army Retrovirus Research Group
Authors: J. G. McNeil
Journal: JAMA (1991)

Because soldiers in the US Army are recurrently tested for the presence of antibody to the human immunodeficiency virus (HIV), HIV seroconversion rates can be directly measured. From November 1985 through October 1989, 429 HIV seroconversions were detected among 718,780 soldiers who contributed 1,088,447 person-years of follow-up time (HIV seroconversion rate, 0.39 per 1000 person-years). Period-specific seroconversion rates declined significantly from 0.49 per 1000 person-years (November 1985 through October 1987) to 0.33 per 1000 person-years (November 1987 through October 1988) to 0.29 per 1000 person-years (November 1988 through October 1989). The HIV seroconversion risk among active-duty soldiers was significantly associated with race/ethnic group, age, gender, and marital status. Based on these trends, we estimate that approximately 220 soldiers (95% confidence interval, 160 to 297 soldiers) were infected with HIV during 1989 and 1990, with potentially fewer in future years.
CUTIS VERTICIS GYRATA
Authors: Peter Bassoe
Journal: JAMA (1926)

To the Editor:  —InThe Journal, April 10, p. 1126, Dr. Raymond J. Sisson, in discussing cutis verticis gyrata, states that only a few cases have been reported, and none were associated with acromegaly. In the article on acromegaly in Endocrinology and Metabolism (edited by Barker and Hoskins)1:831, two cases of cutis verticis gyrata in acromegaly are quoted, one reported by Sabat, the other by C. Adrian. I have seen one case in an acromegalic woman, but this case has not been reported.
Prognosis for babies of less than 28 weeks' gestation
Authors: T H H G Koh
Journal: BMJ (1997)

Editor—Win Tin and colleagues provide further help for parents at risk of delivering babies of less than 28 weeks' gestation.1 They concluded that “these data should not be used to establish an arbitrary ‘threshold’ below which resuscitation should never be offered at birth” but did not mention how many of the 342 babies born at 22 to 24 …
TEMPORAL CHARACTERIZATION OF CARDIAC ISCHEMIA-REPERFUSION INJURY BY FREQUENT MEASUREMENT OF BIOMARKER RELEASE FROM THE ISOLATED RAT HEART
Authors: Jonas Agerlund Povlsen, Bo Løfgren, Christian Dalgas, Nichlas R. Jespersen, Jacob Johnsen, Hans Erik Bøtker
Journal: Journal of the American College of Cardiology (2013)
Severe extravasation injury
Authors: D A R Burd, G Santis, T M Milward
Journal: BMJ (1985)

Occult advanced cervical cancer SIR,-We read with interest the letter by Mr W H Bond (25 May, p 1587) describing a retrospective analysis of stage IA and lB carcinoma of the uterine cervix treated in Birmingham in 1960-4 and 1975-9.The figures described are at odds with regional data extracted from the same source.In 1960-4, 275 cases of invasive cervical cancer in women under 40 years old were registered through the West Midlands region cancer registry.The corre- sponding figure for 1975-9 was 554 cases.Further- more, the proportion of all cases classified as stage 1 disease rose from 37 5% in the earlier period to around 4l1% in the later period, resulting in a 22/5% increase in registrations of stage 1 invasive cervical cancer in the under 40s.A similar trend has been observed in data from the Office of Population Censuses and Surveys.In contrast, Mr Bond's data show no more than a 5% increase in stage 1 disease in women under 40 years between the quoted periods.Changes in disease classification must be con- sidered before interpreting retrospective incidence and survival data.'We recognise, however, that survival data relating to current clinical experiences described by Dr Bruce G Ward and his colleagues (4 May, p 1301) will not be available for several years.
Infants Who Survive Birth at the Edge of Viability
Authors: Mandy Brown Belfort
Journal: JAMA Pediatrics (2013)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Pediatrics HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Pediatrics journal
Balking at radiotherapy may signal underlying anxieties
Authors: Milan Korcok
Journal: JAMA (1983)

To the radiation technologist, the reference to the treatment room as a "torture chamber" was just a joke—an off-the-cuff remark to ease the breast cancer patient's anxiety about yet another therapy session. But for the patient, already feeling helpless and fearful, there was nothing funny about the remark. A World War II refugee, she had lost members of her family in Nazi concentration camp gas chambers. The imagery of "torture" and absolute control by others and their machines was to her very real, intensifying a psychic distress that already threatened her continuation in therapy. Despite the gravity of her disease, she feared therapy almost as much. To many patients refusing to comply with prescribed therapy, such fear is a major impediment to management of their disease. According to Joseph M. Hyland, MD, staff psychiatrist at the Menninger Foundation, Topeka, Kan, this difficulty remains poorly understood by professionals who plan and
Alcohol Consumption and Tissue-Type Plasminogen Activator-Reply
Authors: Paul M. Ridker
Journal: JAMA (1995)

In Reply.  —Our article reports observational data describing a potential mechanism for the cardioprotective effect of alcohol. Contrary to statements by Dr Lands and Dr Strand, we made no comments for or against alcohol use.  We disagree with Lands and Strand that severe malnutrition and/or the presence of active hepatitis could account for the association between t-PA antigen level and alcohol consumption. These alternative hypotheses are implausible explanations of the observed data for several reasons.  First, our study population solely comprised healthy US physicians, making severe protein malnutrition an unlikely confounder for the observed effect. In this regard, it should be noted that stratification by body mass index had no material effect on the association of t-PA antigen level and alcohol use, as indicated in Table 3 of the article. In fact, t-PA antigen levels were, if anything, lower among subjects with lower body mass rather than higher.  Second, current
Frequency of occurrence, mode of development, and significance or rice bodies in rheumatoid joints.
Authors: A J Popert, D L Scott, A C Wainwright, K W Walton, N Williamson, J H Chapman
Journal: Annals of the Rheumatic Diseases (1982)

The incidence of rice bodies (RB) in synovial effusions has been studied in 36 patients with rheumatoid arthritis (RA) and in 12 patients with seronegative inflammatory arthritis (7 cases of Still's disease, 3 of psoriatic arthritis, and 2 of ankylosing spondylitis). In the RA group 50 joints were aspirated before and after saline lavage with a specially designed wide-bore needle. RB were found in 72% overall of the joints studied in this group, 14% on initial simple aspiration and an additional 58% after lavage. In contrast no rice bodies were found in 31 aspirations with lavage by an identical technique in the 12 patients with seronegative synovitis. The RB in RA synovitis occurred both early and late in the course of the disease and were not related to the severity of clinical or radiological changes. However, removal of rice bodies was accompanied by clinical improvement and reduction of synovitis. Macroscopically RB varied in shape and size, some being so large as to preclude effective removal by needles of the gauge customarily employed for joint aspirations. Microscopically the majority of RB were composed of coarsely reticular material reacting immunologically with antifibrinogen and antifibronectin and containing mononuclear cells. Some showed vacuolation suggestive of fibrinolysis, but many showed organisation like that seen in established connective tissues, with the formation of mature collagen, reticulin, and elastin. These findings are discussed in relation to the origin, development, and significance of rice bodies in rheumatoid synovitis.
A very British muddle
Authors: Jane Smith
Journal: BMJ (2006)

The latest row in Britain's NHS is about overseas doctors. The Department of Health last month announced that international medical graduates (from outside the European Union) in training posts will now need a work permit before taking such posts. This puts them in the same position as most non-EU nationals seeking to work in the UK, but doctors in training had until now been exempt.

Not surprisingly, this has caused anger among overseas graduates currently in training (15 April, p 913; bmj.com/cgi/eletters/332/7544/744-a), who now see only uncertainty when their current post comes to an end. …
Feno Decreases Significantly During Improved Symptom Control In Pediatric Patients After Acute Asthma Exacerbations Necessitating Emergency Department Care
Authors: Eric M. Karlin, Tebeb Gebretsadik, Emily W. Langley, Tina V. Hartert, R. Stokes Peebles, Donald H. Arnold
Journal: Journal of Allergy and Clinical Immunology (2014)
FINAL RESULTS OF THE EVEREST II RANDOMIZED CONTROLLED TRIAL OF PERCUTAENOUS AND SURGICAL REDUCTION OF MITRAL REGURGITATION
Authors: Ted Feldman, Laura Mauri, Saibal Kar, Peter Fail, Michael Rinaldi, Richard Smalling, James Hermiller, William Gray, Elyse Foster, Donald Glower
Journal: Journal of the American College of Cardiology (2014)
Car head restraints.
Authors: M R Braddick, G Love
Journal: BMJ (1990)

This short letter describes the results of a survey undertaken to see if motorists were making full use of their head restraints. 150 male drivers were asked to answer a short questionnaire after leaving a 'do it yourself' store. Each driver was then asked to lean back in his seat, and the position of the headrest was assessed. If the top of the head restraint was above eye level it was considered to be correctly positioned. The results showed that although 136 drivers knew that head restraints were a safety feature, only 36 could identify the correct position. In only 50 cases was the head restraint found to be correctly adjusted. A further 54 could be adjusted to a satisfactory height and 46 remained too low even when fully extended. Although this study population cannot be regarded as typical of car drivers and passengers generally, the results suggest that a substantial proportion of car head restraints are too low. Inexpensive measures to educate the motoring public through car handbooks, at services and at Department of Transport Tests are advocated. (TRRL)
Smooth muscle antibodies and alopecia areata
Authors: ROBERT A. MAIN, ROSALENE B. ROBBIE, ELIZABETH S. GRAY, DAVID DONALD, CHARLES H.W. HORNE
Journal: British Journal of Dermatology (1975)

In seventy-eight patients with alopecia areata, the incidence of auto-antibodies to smooth muscle was greater than that in an age and sex matched control population.
Coupling of mGluR/Homer and PSD-95 Complexes by the Shank Family of Postsynaptic Density Proteins
Authors: Jian Cheng Tu, Bo Xiao, Scott Naisbitt, Joseph P. Yuan, Ronald S. Petralia, Paul Brakeman, Andrew Doan, Vinay K. Aakalu, Anthony A. Lanahan, Morgan Sheng, Paul F. Worley
Journal: Neuron (1999)

Shank is a recently described family of postsynaptic proteins that function as part of the NMDA receptor–associated PSD-95 complex (Naisbitt et al., 1999 [this issue of Neuron]). Here, we report that Shank proteins also bind to Homer. Homer proteins form multivalent complexes that bind proline-rich motifs in group 1 metabotropic glutamate receptors and inositol trisphosphate receptors, thereby coupling these receptors in a signaling complex. A single Homer-binding site is identified in Shank, and Shank and Homer coimmunoprecipitate from brain and colocalize at postsynaptic densities. Moreover, Shank clusters mGluR5 in heterologous cells in the presence of Homer and mediates the coclustering of Homer with PSD-95/GKAP. Thus, Shank may cross-link Homer and PSD-95 complexes in the PSD and play a role in the signaling mechanisms of both mGluRs and NMDA receptors.
Fixing Femurs in a Rain Forest
Authors: Mike Mitka
Journal: JAMA (1999)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Coronary bypass graft fate: angiographic grading of 1400 consecutive grafts early after operation and of 1132 after one year.
Authors: G M FitzGibbon, J R Burton, A J Leach
Journal: Circulation (1978)

All 1400 coronary bypass grafts, in 409 survivors of 414 patients undergoing 440 consecutive bypass operations, were selectively opacified in multiplane cineangiograms prior to hospital discharge and 1132 (81%) were restudied at one year. Grafts were graded A (excellent), B (fair) or O (occluded) by separate assessment of proximal and distal anastomoses and bypass trunks. In early graft studies 89% were patent (A and B), 79% graded A; at one year, 81% were patent, 74% graded A. Circumflex-marginal grafts fared less well early, but similarly late, compared with other grafts. Of all grafts graded B early, 37% became A, 39% remained B and 24% were occluded at one year; 90% of early graded A grafts remained so, 4% became B and 6% occluded; the grading system seems to have had useful predictive value. Distal anastomosis defects dictated early B grading in 81.3% of cases, trunk defects in 12.5% and proximal anastomosis defects in 2.7%. Trunk defects carried a worse prognosis for occlusion than did distal anastomosis defects. Side-to-side, vein-coronary anastomoses had a significantly higher patency rate than terminal end-to-side coronary anastomoses with the same veins.
Ratio of cardiopulmonary blood volume to stroke volume as an index of cardiac function in animals and in man
Authors: J. J VAN DER WALT, J. M VAN ROOYEN, G. D CILLIERS, J. C J VAN RYSSEN, M. N VAN AARDE
Journal: Cardiovascular Research (1981)

Journal Article Ratio of cardiopulmonary blood volume to stroke volume as an index of cardiac function in animals and in man Get access JURGENS J VAN DER WALT, JURGENS J VAN DER WALT * From the Institute for Physiological Research, Dept of Physiology, Potchefstroom University for C H E, Potchefstroom 2520, South Africa *Address for reprints: J J van der Walt D Sc, Dept of Physiology (168), Potchefstroom University for C H E, Potchefstroom 2520, South Africa. Search for other works by this author on: Oxford Academic PubMed Google Scholar JOHANNES M VAN ROOYEN, JOHANNES M VAN ROOYEN From the Institute for Physiological Research, Dept of Physiology, Potchefstroom University for C H E, Potchefstroom 2520, South Africa Search for other works by this author on: Oxford Academic PubMed Google Scholar GEORGE D CILLIERS, GEORGE D CILLIERS From the Institute for Physiological Research, Dept of Physiology, Potchefstroom University for C H E, Potchefstroom 2520, South Africa Search for other works by this author on: Oxford Academic PubMed Google Scholar JOHANNES C J VAN RYSSEN, JOHANNES C J VAN RYSSEN From the Institute for Physiological Research, Dept of Physiology, Potchefstroom University for C H E, Potchefstroom 2520, South Africa Search for other works by this author on: Oxford Academic PubMed Google Scholar MICHIEL N VAN AARDE MICHIEL N VAN AARDE From the Institute for Physiological Research, Dept of Physiology, Potchefstroom University for C H E, Potchefstroom 2520, South Africa Search for other works by this author on: Oxford Academic PubMed Google Scholar Cardiovascular Research, Volume 15, Issue 10, October 1981, Pages 580–587, https://doi.org/10.1093/cvr/15.10.580 Published: 01 October 1981
Effects of the acute administration of a specific inducible nitric oxide synthase inhibitor (NOS) on splanchnic circulation in cirrhotic rats with ascites
Authors: R. Craighero, W. Jiménez, P. Angeli, V. Dalla Libera, R. Volpin, G. Fernandez, M. Morales Ruiz, A. Sticca, V. Arroyo, J. Rodés, A. Gatta
Journal: Journal of Hepatology (2000)
Rituals of Surgery
Authors: Nancy C. Andreasen
Journal: JAMA (1974)

This is a volume of short stories written by a surgeon, inevitably inviting comparison with other physician-writers such as Oliver Wendell Holmes, Sir Thomas Browne, or Rabelais. Selzer's style most closely resembles the bluntness and brutality of the latter, and he seems to share his ironic view of the human situation. As the title indicates, the stories are joined by a common thread of subject matter. Nearly all center on a situation related to medicine—an old fable about a 16th-century rhinoplasty, the sexual and surgical exploits and exploitations of a young surgeon stationed in Korea, the seduction of an orderly by a nurse, in a morgue, a physician accidentally noting a possible breast malignancy in a prostitute with whom he spends the night, a man precipitated into psychotic violence after a treasured birthmark is removed at his fiancee's request, and another man precipitated into psychotic regression through the process of
Psychosocial Disorders in Young People: Time Trends and Their Causes
Authors: J. H. Hendriks
Journal: BMJ (1995)

Ed Michael Rutter, David J Smith Wiley, £49.95, pp 843 ISBN 0 471 95054 8

Written by a European academic study group, with contributions by experts in child and adolescent psychiatry, criminology, and epidemiology, Psychosocial Disorders in Young People targets disorders that tend “to rise or peak in frequency during the teenage years.” These are: crime; suicide and suicidal behaviour; depression; eating disorders (anorexia nervosa and bulimia); and the abuse of alcohol and psychoactive drugs. The study explores individual development and other relevant factors within …
16,16-Dimethyl-PGE2 Protection Against α — Napthy lisothiocy anate - Induced Experimental Cholangitis in the Rat
Authors: Mary J. Ruwart, Bob D. Rush, Nanette M. Friedle, Jerzy Stachura, Andrzej Tarnawski
Journal: Hepatology (1984)

Male rats were treated with subcutaneous vehicle or 16, 16-dimethyl-PGE 2 (dmPGE 2 , 100 μg per kg), 24,18 and 0.5 hr prior to and 6, 24 and 30 hr after challenge with oral α1-napthylisothio-cyanate (ANIT, 30 mg per kg). Forty-eight hours after challenge, rats were sacrificed by decapitation; serum and liver samples were taken for biochemical and histological analysis, respectively. Rats treated with vehicle (2% ethanol in saline) and ANIT exhibited elevations in alkaline phosphatase, SGPT and bilirubin as well as cholangitis and mild parenchymal necrosis. Rats treated with dmPGE2 and ANIT had normal serum biochemical findings, no necrosis and only mild proliferation of bile duct epithelium. Thus, dmPGE 2 may be able to protect the rat liver against the deleterious effects of orally administered ANIT.
Malignant clinical features of anaplastic gliomas without IDH mutation
Authors: Ichiyo Shibahara, Yukihiko Sonoda, Takuhiro Shoji, Masayuki Kanamori, Ryuta Saito, Tomoo Inoue, Tomohiro Kawaguchi, Yoji Yamashita, Takashi Watanabe, Toshihiro Kumabe, Mika Watanabe, Hiroyoshi Suzuki, Teiji Tominaga
Journal: Neuro-Oncology (2014)

Diagnosis of WHO grade III anaplastic gliomas does not always correspond to its clinical outcome because of the isocitrate dehydrogenase (IDH) gene status. Anaplastic gliomas without IDH mutation result in a poor prognosis, similar to grade IV glioblastomas. However, the malignant features of anaplastic gliomas without IDH mutation are not well understood. The aim of this study was to examine anaplastic gliomas, in particular those without IDH mutation, with regard to their malignant features, recurrence patterns, and association with glioma stem cells. We retrospectively analyzed 86 cases of WHO grade III anaplastic gliomas. Data regarding patient characteristics, recurrence pattern, and prognosis were obtained from medical records. We examined molecular alterations such as IDH mutation, 1p19q loss, TP53 mutation, MGMT promoter methylation, Ki67 labeling index, and CD133, SOX2, and NESTIN expression. Of the 86 patients with anaplastic gliomas, 58 carried IDH mutation, and 40 experienced recurrence. The first recurrence was local in 25 patients and distant in 15. Patients without IDH mutation exhibited significantly higher CD133 and SOX2 expression (P = .025 and .020, respectively) and more frequent distant recurrence than those with IDH mutation (P = .022). Patients with anaplastic gliomas without IDH mutation experienced distant recurrence and exhibited glioma stem cell markers, indicating that this subset may share some malignant characteristics with glioblastomas.
Erwinia asparaginase achieves therapeutic activity after pegaspargase allergy: a report from the Children’s Oncology Group
Authors: Wanda L. Salzer, Barbara Asselin, Jeffrey G. Supko, Meenakshi Devidas, Nicole A. Kaiser, Paul Plourde, Naomi J. Winick, Gregory H. Reaman, Elizabeth Raetz, William L. Carroll, Stephen P. Hunger
Journal: Blood (2013)