Diabetic Diarrhea and Somatostatin
Authors: Shih-Tzer Tsai, Aaron I. Vinik, John F. Brunner
Journal: Annals of Internal Medicine (1986)

Letters and Corrections1 June 1986Diabetic Diarrhea and SomatostatinSHIH-TZER TSAI, M.D., AARON I. VINIK, M.D., JOHN F. BRUNNER, M.D.SHIH-TZER TSAI, M.D.Search for more papers by this author, AARON I. VINIK, M.D.Search for more papers by this author, JOHN F. BRUNNER, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-104-6-894_1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: Somatostatin (1) and its synthetic analogs have been shown to reduce diarrhea in patients with short bowel syndrome (2), ileostomy (3), and tumor-induced secretory diarrhea (4). We describe the effect of a new, long-acting somatostatin analog, SMS 201-995 (Sandoz Inc., East Hanover, New Jersey), on diarrhea refractory to all forms of therapy in an insulin-dependent diabetic patient with autonomic neuropathy (5) and a 10-year history of intermittent loose bowel movements.A 39-year-old woman with poorly controlled diabetes for 17 years was admitted with profuse, painless, watery diarrhea that had lasted 15 months and was unresponsive to treatment....References1. DAVIS G, CAMP R, and KREJS G. Effects of somatostatin infusion on jejunal water and electrolyte transport in a patient with secretory diarrhea due to malignant carcinoid syndrome. Gastroenterology. 1980;78:346-9. CrossrefMedlineGoogle Scholar2. DHARMSATHAPHORN K, GORELICK F, and SHERWIN R. Somatostatin decreases diarrhea in patients with the short bowel syndrome. J Clin Gastroenterol. 1982;4:521-4. CrossrefMedlineGoogle Scholar3. WILLIAMS N, COOPER J, and AXON A. Use of a long-acting somatostatin analogue in controlling life-threatening ileostomy diarrhea. Br Med J. 1984;2:1027-8. CrossrefGoogle Scholar4. SANTANGELO W, O'DORISIO T, KIM J, SEVERINO G, and KREJS G. Pancreatic cholera syndrome: effect of a synthetic somatostatin analog on intestinal water and ion transport. Ann Intern Med. 1985;103:363-7. LinkGoogle Scholar5. VINIK A and GLOWNIAK J. Hormonal secretion in diabetic autonomic neuropathy. NY State J Med. 1982;82:871-86. MedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: SHIH-TZER TSAI, M.D.; AARON I. VINIK, M.D.; JOHN F. BRUNNER, M.D. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byDiabetes Mellitus and the ColonDiabetic Autonomic NeuropathyGastrointestinal Complications of Diabetes MellitusDIABETES AND THE GASTROINTESTINAL TRACTThe adverse effects of octreotide on the healing of colonic anastomoses in ratsDiabetic autonomic neuropathyConsensus statement: Octreotide dose titration in secretory diarrheaRapid renal deterioration secondary to oxalate in a patient with diabetic gastroenteropathyOctreotide in the treatment of diarrhoea induced by coeliac plexus blockReview article: anti-diarrhoeal pharmacology and therapeuticsExpanding uses of octreotideChronic Diarrhea in Diabetes Mellitus: Mechanisms and an Approach to Diagnosis and TreatmentEffective treatment of diabetic diarrhoea with somatostatin analogue, octreotide.USE OF GUT PEPTIDE RECEPTOR AGONISTS AND ANTAGONISTS IN GASTROINTESTINAL DISEASESOctreotide--a new treatment for diarrhoea in familial amyloidotic polyneuropathy.Diabetic diarrheaOctreotide in the Treatment of Disorders of the Gastrointestinal SystemDiarrhoea-an unrecognised hazard of coeliac plexus blockSevere posthemicolectomy diarrhea: Evaluation and treatment with SMS 201-995Somatostatin and Somatostatin Analogue (SMS 201-995) in Treatment of Hormone-Secreting Tumors of the Pituitary and Gastrointestinal Tract and Non-Neoplastic Diseases of the GutPhillip Gorden, MD, Richard J. Comi, MD, Paul N. Maton, MD, Vay Liang W. Go, MDClinical aspects of diabetic neuropathiesTreatment of diabetic diarrhea and orthostatic hypotension with somatostatin analogue SMS 201–995Somatostatin analogue (SMS 201-995) in the management of gastroenteropancreatic tumors and diarrhea syndromes 1 June 1986Volume 104, Issue 6Page: 894-894KeywordsDiarrheaIleostomyInsulinNeuropathySomatostatin ePublished: 1 December 2008 Issue Published: 1 June 1986 PDF downloadLoading ...