"METASTATIC" CALCIFICATION IN SOFT TISSUES OF LEGS IN OSTEITIS DEFORMANS; CASE REPORT
Authors: Bernard Seligman, Louis Nathanson
Journal: Annals of Internal Medicine (1945)

Case Reports1 July 1945"METASTATIC" CALCIFICATION IN SOFT TISSUES OF LEGS IN OSTEITIS DEFORMANS; CASE REPORTBERNARD SELIGMAN, M.D., F.A.C.P., LOUIS NATHANSON, M.D., M.SC. (MED.)BERNARD SELIGMAN, M.D., F.A.C.P., LOUIS NATHANSON, M.D., M.SC. (MED.)Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-23-1-82 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptSoft tissue, "metastatic" calcification has been reported in only one previous case of osteitis deformans, which was described by Wells and Holley1 Metastatic calcification is to be distinguished from calcinosis. The former represents calcification of apparently healthy tissue due to changes in the composition of the blood calcium and phosphorus salts, phosphatase, or alkalinity. The latter represents another stage of an underlying pathologic process of certain tissue such as occurs in scleroderma, sclerodactyly, Raynaud's disease, dermatomyositis, progressive lipoid dystrophy, myositis ossificans, etc.2In a 59 year old man who had Paget's disease for six to seven years and had received...Bibliography1. WELLSHOLLEY HGSW: Metastatic ossification in osteitis deformans (Paget's disease of bone), Arch. Path., 1942, xxxiv, 435. Google Scholar2. ROTHSTEINWELT JLS: Three cases of calcinosis universalis and calcinosis circumscripta in infancy and in childhood; review of literature, Am. Jr. Dis. Child., 1936, lii, 368. CrossrefGoogle Scholar3. SNAPPER I: Medical clinics on bone diseases, Interscience, 1943, p. 142. Google Scholar4. Editorial: Urinary calculi in bone diseases, Jr. Am. Med. Assoc., 1936, cvi, 469. Google Scholar5. MOEHLIGADLER RCS: Carbohydrate metabolism disturbance in osteoporosis and Paget's disease; associated soft tissue disturbances and results of various therapeutic procedures, Surg., Gynec., and Obst., 1937, lxiv, 747. Google Scholar6. SUGARBAKER ED: Osteitis deformans (Paget's disease of bones); review of 51 cases, Am. Jr. Surg., 1940, xlviii, 414. CrossrefGoogle Scholar7. BODANSKYBODANSKY MO: Biochemistry of disease, 1940, Macmillan Co., New York, p. 411. Google Scholar8. ALBRIGHTAUBBAUER FJCW: Hyperparathyroidism: a common and polymorphic condition as illustrated by 17 proved cases from one clinic, Jr. Am. Med. Assoc., 1934, cii, 1277. Google Scholar9. ALBRIGHTSMITHRICHARDSON FPHAM: Postmenopausal osteoporosis: Its clinical features, Jr. Am. Med. Assoc., 1941, cxvi, 2473. Google Scholar10. LONDONBERNHEIM IMAR: Calcium tolerance curves in Paget's disease of bone, Jr. Lab. and Clin. Med., 1937, xxiii, 18. Google Scholar11. JAFFEEBODANSKY HLA: Serum calcium: clinical and biochemical considerations, Jr. Mt. Sinai Hosp., 1943, ix, 901. Google Scholar12. WELLSDUNLAP HGCE: Disseminated ossification of lungs, Arch. Path., 1943, xxxv, 420. Google Scholar13. NUNEZARTHUR BEPS: Calcinosis: report of 2 cases, Med. Ann. District of Columbia, 1943, xii, 301. Google Scholar14. BALIN M: Parathyroidism, Ann. Surg., 1932, xcvi, 649. CrossrefGoogle Scholar15. GILLSTEIN ABI: Bone metabolism: its principles and relation to orthopedic surgery, Jr. Bone and Jt. Surg., 1936, xviii, 941. Google Scholar16. GARDNERPFEIFFER WUCA: Influence of estrogens and androgens on the skeletal system, Physiol. Rev., 1943, xxiii, 139. CrossrefGoogle Scholar17. BERMAN L: Studies of Paget's disease; effect of adrenal cortical extract treatment upon blood phosphatase in Paget's disease, Endocrinology, 1936, xx, 226. CrossrefGoogle Scholar18. MARINE D: Personal communication. Google Scholar19. GOMORI G: Calcification and phosphatase, Am. Jr. Path., 1943, xix, 197. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Brooklyn, New York*Received for publication April 1, 1944.From the Jewish Sanitarium and Chronic Hospital, Brooklyn, New York. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byRheumatic manifestations of Paget's disease of boneDie Pagetsche KnochenerkrankungHeritable disorders of connective tissueThe Mechanism and Incidence of Cardiovascular Changes in Paget's Disease (Osteitis Deformans)Die Ostitis deformans Paget unter Berücksichtigung ihrer VererbungThe Complications of Osteitis DeformansAngioid Streaks⋆ 1 July 1945Volume 23, Issue 1Page: 82-91KeywordsBloodCalciumDermatomyositisMyositisPhosphatasesPhosphorusProgressive diseasesSaltsSclerodermaSoft tissues ePublished: 1 December 2008 Issue Published: 1 July 1945 PDF downloadLoading ...