tbuckley/cabot-search huggingface dataset:
THE PROBLEM OF THE DIAGNOSIS OF GASTRIC LESIONS
Authors: G C HENNIG, H D HARVEY
Journal: Annals of Internal Medicine (1959)

Article1 January 1959THE PROBLEM OF THE DIAGNOSIS OF GASTRIC LESIONSGEORGE C. HENNIG, M.D., F.A.C.P., HAROLD D. HARVEY, M.D., F.A.C.S.GEORGE C. HENNIG, M.D., F.A.C.P., HAROLD D. HARVEY, M.D., F.A.C.S.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-50-1-43 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe present study was undertaken in an attempt to estimate the frequency with which the clinician is faced with the problem of a gastric lesion of questionable diagnosis. If the problem is approached purely from the standpoint of surgically proved malignancies, it does not assume its proper importance. In addition to the fungating lesions in which ulceration is not necessarily a prominent feature, there is a large group of nonfungating gastric ulcerations in which malignancy must be suspected. It is this latter group to which this paper will direct the major portion of its attention.The case material in this...Bibliography1. GoldenStout RAP: Superficial spreading carcinoma of the stomach, Am. J. Roentgenol. 59: 157 (Feb.) 1948. Google Scholar2. HarveyTitheringtonStoutSt. John HDJBAPFB: Gastric carcinoma, Cancer 4: 717 (July) 1951. CrossrefMedlineGoogle Scholar3. FloodHennig CAGC: Recurrence of gastric ulcer under medical management, Gastroenterology 16: 57 (Sept.) 1950. CrossrefMedlineGoogle Scholar4. HarveySt. JohnVolk HDFBH: Peptic ulcer: late follow-up results after partial gastrectomy: analysis of failures, Ann. Surg. 138: 680 (Nov.) 1953. CrossrefMedlineGoogle Scholar5. HarveyLattes HDR: The differential diagnosis between benign and malignant ulcers at operation, J. Nat. Cancer Inst. 13: 1065 (Feb.) 1953. MedlineGoogle Scholar6. RunyeonHoerr WKSO: The gastric ulcer problem: prognosis in masked malignancy, Gastroenterology 32: 415, 1957. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: New York, N. Y.*Received for publication April 8, 1958.From the Departments of Medicine and Surgery, College of Physicians and Surgeons, Columbia University, New York, and the Medical and Surgical Services of the Presbyterian Hospital in the City of New York.Requests for reprints should be addressed to George C. Hennig, M.D., Harkness Pavilion, 180 Fort Washington Avenue, New York 32, N. Y. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 January 1959Volume 50, Issue 1Page: 43-50KeywordsGastric ulcersGastroenterology and hepatologyHospital medicineLesionsSurgeonsSurgeryUlcers Issue Published: 1 January 1959 PDF downloadLoading ...
Perspectives and Potential Applications of Mitochondria‐Targeted Antioxidants in Cardiometabolic Diseases and Type 2 Diabetes
Authors: Milagros Rocha, Nadezda Apostolova, Jose Raul Herance, Susana Rovira‐Llopis, Antonio Hernandez‐Mijares, Victor M. Victor
Journal: Medicinal Research Reviews (2013)

Abstract There is abundant evidence to suggest that mitochondrial dysfunction is a main cause of insulin resistance and related cardiometabolic comorbidities. On the other hand, insulin resistance is one of the main characteristics of type 2 diabetes, obesity, and metabolic syndrome. Lipid and glucose metabolism require mitochondria to generate energy, and when O 2 consumption is low due to inefficient nutrient oxidation, there is an increase in reactive oxygen species, which can impair different types of molecules, including DNA, lipids, proteins, and carbohydrates, thereby inducing proinflammatory processes. Factors which contribute to mitochondrial dysfunction, such as mitochondrial biogenesis and genetics, can also lead to insulin resistance in different insulin‐target tissues, and its association with mitochondrial dysfunction can culminate in the development of cardiovascular diseases. In this context, therapies that improve mitochondrial function may also improve insulin resistance. This review explains mechanisms of mitochondrial function related to the pathological effects of insulin resistance in different tissues. The pathogenesis of cardiometabolic diseases will be explained from a mitochondrial perspective and the potential beneficial effects of mitochondria‐targeted antioxidants as a therapy for modulating mitochondrial function in cardiometabolic diseases, especially diabetes, will also be considered.
Abstract P285: Psychosocial Factors are Associated with Blood Pressure Progression among African Americans in the Jackson Heart Study
Authors: Cassandra D Ford, Mario Sims, John C Higginbotham, Martha R Crowther, Sharon B Wyatt, Solomon K Musani, Thomas J Payne, Jason Parton
Journal: Circulation (2014)

Background: African Americans (AA) have a higher risk of hypertension than other race/ethnic groups. Research that examines the associations of psychosocial factors with longitudinal changes in blood pressure (BP) and incident hypertension among AA is limited. Using Jackson Heart Study (JHS) data, we hypothesized that negative affect and stress are positively associated with BP progression and incident hypertension among AA. Methods: The JHS is an observational, community-based study of cardiovascular disease (CVD) in AA. Our sample consisted of 1,668 normotensive participants at baseline (2000-2004) (mean age 47±12; 61% women). We investigated sex-pooled associations of negative affect (cynical distrust, anger in, anger out and depressive symptoms) and stress (perceived stress, weekly stress inventory (WSI)-event, WSI-impact and negative life events) with BP progression (an increase by one BP stage as defined by JNC VII), incident hypertension and longitudinal changes in systolic and diastolic BP by examination 2 (2005-2008). Poisson regression analysis was utilized to examine the prevalence ratios (PR 95% CI) of BP tracking with psychosocial factors, adjusting for baseline age, sex, socioeconomic status (SES) and hypertension risk factors. Results: Men had higher cynical distrust scores than women (p&lt;.0001). Women had higher anger out, depressive symptoms and perceived stress scores than men (p&lt;.05). Fifty six percent of the sample (934 cases) had BP progression from 2000 to 2008. After adjustment for age and sex, a high anger-out score was associated with a 20% increased prevalence of BP progression compared to a low anger-out score (PR 1.20, 95%CI 1.05,1.36). This association attenuated after adjustment for hypertension risk factors and became non-significant. High depressive symptoms score was associated with BP progression in the age, sex and SES-adjusted model (PR, 1.14 95%CI 1.00,1.30), but not in the fully-adjusted models. High WSI-event scores were associated with BP progression in the fully-adjusted model (PR, 1.21 95% CI 1.04,1.40). Psychosocial factors were not associated with incident hypertension. Conclusions: Psychosocial factors were associated with BP progression, with the strongest evidence for number of stressful events that occurred. Further research is needed to better understand the pathway between exposure to negative affect and stress and BP progression among AA. Keywords: psychosocial, hypertension, health disparities, African Americans, Jackson Heart Study Category: Hypertension
<i>Flowers on Table</i>
Authors: Juliana M. Walker
Journal: JAMA (2003)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Abstract P2-13-07: Prophylactic mastectomy in young women with breast cancer
Authors: Cristiane Metran Nascente, Frances Wright, Christel Helwig, Nim Li, Rodica Mandel, Alex Kiss, Ellen Warner
Journal: Cancer Research (2015)

Abstract Background: In recent years women with unilateral breast cancer (BC) have been increasingly requesting contralateral or bilateral prophylactic mastectomy (PM) despite only requiring unilateral mastectomy (M) or lumpectomy (L) respectively. This trend has been observed even in women at low risk for contralateral BC, particularly among younger women. Objective: Determine the rates of ‘unexplained’ PM (UPM) and factors associated with this choice, among a prospective cohort of newly diagnosed young women with BC at our centre. Methods: We reviewed the records of all patients diagnosed with BC at age ≤ 40 years from Feb ‘08 to Sept ’13 at Sunnybrook who consented to have their clinical data entered in a prospective research database. Psychosocial data - HADS [Hospital Anxiety and Depression Scale] and IES [Impact of Event Scale] - were prospectively collected from all consenting women at baseline and at completion of active treatment. Among the 149 patients treated with curative intent, 43 received unilateral M, 59 L and 47 contralateral or bilateral PM. These groups were compared with respect to demographics, risk factors, use of pre-operative MRI, pathology, treatment and surgeon gender. Differences in variables between the groups were analyzed using analysis of variance for continuous variables and chi-square test for categorical variables. Results: The mean age of all patients was 35 years old (21-40 range). Among the 47 patients who had PM, the first surgery was L for 15 (32%), unilateral M for 27 (57%) and bilateral M for 5 (11%). Twenty-four (51%) fulfilled high risk criteria (19 BRCA mutation, 4 strong family history, 1 chest radiation) and 2 (4%) had suspicious findings in the contralateral breast. The other twenty-one patients (45%) underwent UPM for "peace of mind" alone. Thirty-three (33%) of UPM patients had T3-4 tumors. There were no statistically significant differences between the UPM group and the combined M plus L groups, except for more multicentric/ multifocal disease in the UPM groups (43% vs 9% p≤0.0001). Discussion: Fourteen percent of young women at our centre, a 1/3 with a relatively poor prognosis had UPM. Data correlating surgical choice with baseline and follow-up psychological variables will be presented. There appears to be a need for an educational/psychological intervention at the time of BC diagnosis for non-high-risk women contemplating preventive breast surgery to ensure that such a choice is truly informed. Citation Format: Cristiane Metran Nascente, Frances Wright, Christel Helwig, Nim Li, Rodica Mandel, Alex Kiss, Ellen Warner. Prophylactic mastectomy in young women with breast cancer [abstract]. In: Proceedings of the Thirty-Seventh Annual CTRC-AACR San Antonio Breast Cancer Symposium: 2014 Dec 9-13; San Antonio, TX. Philadelphia (PA): AACR; Cancer Res 2015;75(9 Suppl):Abstract nr P2-13-07.
Heroin Detoxification—Reply
Authors: Eric D. Collins, Herbert D. Kleber, Robert A. Whittington
Journal: JAMA (2006)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2022 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Abstract 4403: Stent-based Liposomal Gene Delivery: Characterization of Target Cell Population, Pattern of Expression and Therapeutic Potential of Lipostents
Authors: Faisal Sharif, Sean O Hynes, Karl McCullagh, Sandra Ganly, Udo Greiser, James Crowley, Peter McHugh, Kieran Daly, Timothy O'Brien
Journal: Circulation (2009)
Prevention of Hypoglycemia During Exercise in Children With Type 1 Diabetes by Suspending Basal Insulin
Authors: Eva Tsalikian, Craig Kollman, William B Tamborlane, Roy W Beck, Rosanna Fiallo-Scharer, Larry Fox, Kathleen F Janz, Katrina J Ruedy, Darrell Wilson, Dongyuan Xing, Stuart A Weinzimer
Journal: Diabetes Care (2006)

Strategies for preventing hypoglycemia during exercise in children with type 1 diabetes have not been well studied. The Diabetes Research in Children Network (DirecNet) Study Group conducted a study to determine whether stopping basal insulin could reduce the frequency of hypoglycemia occurring during exercise.Using a randomized crossover design, 49 children 8-17 years of age with type 1 diabetes on insulin pump therapy were studied during structured exercise sessions on 2 days. On day 1, basal insulin was stopped during exercise, and on day 2 it was continued. Each exercise session, performed from approximately 4:00-5:00 p.m., consisted of four 15-min treadmill cycles at a target heart rate of 140 bpm (interspersed with three 5-min rest breaks over 75 min), followed by a 45-min observation period. Frequently sampled glucose concentrations (measured in the DirecNet Central Laboratory) were measured before, during, and after the exercise.Hypoglycemia (< or = 70 mg/dl) during exercise occurred less frequently when the basal insulin was discontinued than when it was continued (16 vs. 43%; P = 0.003). Hyperglycemia (increase from baseline of > or = 20% to > or = 200 mg/dl) 45 min after the completion of exercise was more frequent without basal insulin (27 vs. 4%; P = 0.002). There were no cases of abnormal blood ketone levels.Discontinuing basal insulin during exercise is an effective strategy for reducing hypoglycemia in children with type 1 diabetes, but the risk of hyperglycemia is increased.
The role of the palatine tonsils in the pathogenesis and treatment of psoriasis
Authors: S.L. Sigurdardottir, R.H. Thorleifsdottir, H. Valdimarsson, A. Johnston
Journal: British Journal of Dermatology (2012)

Psoriasis is a common chronic skin disease with strong genetic associations and environmental triggers. Patients with psoriasis develop sore throats much more frequently than nonpsoriatic individuals and it is well documented that streptococcal throat infections can trigger the onset of psoriasis, and such infections cause exacerbation of chronic psoriasis. It is now generally accepted that psoriatic lesions are caused by abnormal reactivity of specific T lymphocytes in the skin. However, it has been shown in recent years that activation of specific immunity is always preceded by activation of nonspecific innate immune mechanisms, and that abnormalities in the innate immune system can cause dysregulation in specific immune responses. Here we explore the possible immune mechanisms that are involved in the link between infection of the tonsils and this inflammatory skin disease. Moreover, we survey the literature and discuss the suitability of tonsillectomy as a treatment for psoriasis.
Abstract 32: The role of Lrig1 signaling in mammary gland development and tumorigenesis
Authors: Catalina Simion, Qian J. Chen, Charles L. Wilkerson, Hanine Rafidi, Alexander D. Borowsky, Colleen Sweeney
Journal: Cancer Research (2015)

Abstract Lrig1 is a transmembrane leucine-rich repeat protein and a negative regulator of oncogenic receptor tyrosine kinases (RTKs) such as the ErbB family members. The Sweeney lab recently demonstrated that under-expression of Lrig1 predicts poor prognosis in breast cancer. Breast cancer patients with high Lrig1 expression show significantly longer relapse-free survival, identifying Lrig1 as a new prognostic marker. Recently, Lrig1 was found to be a tumor suppressor in intestinal tissue. It was shown that Lrig1 null mice develop ErbB receptor-dependent duodenal adenomas. Based on Lrig1's function as a negative regulator of RTKs and its reported tumor suppressor activity in intestinal epithelium, we hypothesized that Lrig1 null mice would be susceptible to mammary tumorigenesis. To characterize the function of Lrig1 in the mammary gland, we compared mammary development in Lrig1 wild type (+/+) and null (-/-) mice at regular intervals from 4 to 12 weeks. Mice were screened for evidence of hyperplasia, pre-malignant lesions or tumors by whole mount analysis across age and the intensity of specific proteins was surveyed by western blot. Organotypic growth of the mammary epithelial cells from wild type and null mice was examined in three-dimensional cell culture to examine whether any phenotypes are inherent to the epithelium. Since Lrig1 has been defined as a stem cell marker in the intestine, its role in stem cell maintenance was determined by examining the impact of Lrig1 loss on mammary stem cells. Although these studies are ongoing, early results indicate an increase in the amount of Lrig1-target proteins by western blot in the Lrig1-/- mice as opposed to the Lrig1+/+ mice mammary gland tissue. Epithelium from Lrig1-/- mice present an exaggerated branching response when stimulated with TGFα in comparison to Lrig1+/+ epithelium. Our studies also indicate that Lrig1-/- mammary glands are enriched in stem cells when compared to Lrig1+/+ mammary glands. In addition, a number of proliferative lesions were encountered in the mammary gland whole mounts of the Lrig1-/- mice, but not that of the Lrig1+/+ mice, which strongly suggests that Lrig1 plays a growth suppressor role in the mammary gland. Citation Format: Catalina Simion, Qian J. Chen, Charles L. Wilkerson, Hanine Rafidi, Alexander D. Borowsky, Colleen Sweeney. The role of Lrig1 signaling in mammary gland development and tumorigenesis. [abstract]. In: Proceedings of the 106th Annual Meeting of the American Association for Cancer Research; 2015 Apr 18-22; Philadelphia, PA. Philadelphia (PA): AACR; Cancer Res 2015;75(15 Suppl):Abstract nr 32. doi:10.1158/1538-7445.AM2015-32
BERI-BERI; SEVERE MANIFESTATIONS OF BOTH THE 'WET' AND 'DRY' FORMS IN THE SAME PATIENT; RECOVERY FOLLOWING TREATMENT
Authors: Bernard S. Epstein, Alexander Gerber
Journal: Annals of Internal Medicine (1939)

Case Reports1 October 1939BERI-BERI; SEVERE MANIFESTATIONS OF BOTH THE 'WET' AND 'DRY' FORMS IN THE SAME PATIENT; RECOVERY FOLLOWING TREATMENTBERNARD S. EPSTEIN, M.D., ALEXANDER GERBER, M.D.BERNARD S. EPSTEIN, M.D.Search for more papers by this author, ALEXANDER GERBER, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-13-4-728 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe cardiovascular complications of inadequate vitamin consumption have been traced to vitamin B1 deficiency. The specificity and cure of the cardiac manifestations of this avitaminosis recently were reaffirmed by Hashimoto,1 who reported a case in which dramatic recovery followed the intravenous administration of minute quantities of purified and concentrated vitamin B1.The condition may manifest itself in a 'dry' type, characterized by muscle wasting and peripheral neuritis, or a 'wet' type in which generalized edema and cardiovascular disturbances predominate. The combination of an acute form of one type with a mild form of the other is uncommon, and likewise the...References1. HASHIMOTO H: Acute pernicious form of beri-beri and its treatment by intravenous administration of vitamin B-1, Am. Heart Jr., 1937, xiii, 580-588. CrossrefGoogle Scholar2. WEISSWILKINS SRW: Disturbances of the cardiovascular system in nutritional deficiency, Jr. Am. Med. Assoc., 1937, cix, 786-793. CrossrefGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Brooklyn, N. Y.*Received for publication August 3, 1938.From The Jewish Hospital and from the Jewish Sanitarium and Hospital for Chronic Diseases, Brooklyn, N. Y. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 October 1939Volume 13, Issue 4Page: 728-737KeywordsCardiac musclesCardiovascular diseasesEdemaPatientsSpecificity ePublished: 1 December 2008 Issue Published: 1 October 1939 PDF downloadLoading ...