PIGMENTED SPOTS OF THE ORAL MUCOSA, LIPS AND DIGITS ASSOCIATED WITH GASTROINTESTINAL POLYPOSIS
Authors: A I BORTZ, F H BETHELL
Journal: Annals of Internal Medicine (1955)

Case Reports1 February 1955PIGMENTED SPOTS OF THE ORAL MUCOSA, LIPS AND DIGITS ASSOCIATED WITH GASTROINTESTINAL POLYPOSISALLEN I. BORTZ, M.D., FRANK H. BETHELL, M.D., F.A.C.P.ALLEN I. BORTZ, M.D.Search for more papers by this author, FRANK H. BETHELL, M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-42-2-424 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe complete syndrome of intestinal polyposis and melanin spots of the oral mucosa, lips and digits was first described by Jeghers1in 1944. However, as early as 1896 Hutchinson2reported unusual black pigmented spots on the face and oral mucosa of twins, and Weber3in 1919 reported that one of these twins died of intussusception at the age of 20. Peutz4in 1921 demonstrated a familial incidence of this syndrome by finding both pigmentation and intestinal polyposis affecting several members of the same family. He apparently did not believe that there was an important association between the two components of...Bibliography1. Jeghers H: Pigmentation of skin, New England J. Med. 231: 88, 122, and 181, 1944. CrossrefGoogle Scholar2. Hutchinson J: Pigmentation of lips and mouth, Arch. Surg. London 7: 290, 1896. Google Scholar3. Weber FP: Patches of deep pigmentation of oral mucous membrane not connected with Addison's disease, Quart. J. Med. 12: 404, 1919. CrossrefGoogle Scholar4. Peutz JL: Very remarkable case of familial polyposis of mucous membrane of intestinal tract and nasopharynx accompanied by peculiar pigmentation of skin and mucous membrane, Nederl. tijdschr. v. geneesk. 10: 134, 1921. Google Scholar5. Foster DB: Adenocarcinoma of small intestine in father and daughter, Brit. M. J. 2: 78, 1944. CrossrefMedlineGoogle Scholar6. JeghersMcKusickKatz HVAKH: Generalized intestinal polyposis and melanin spots of the oral mucosa, lips and digits, New England J. Med. 241: 993 and 1031, 1949. CrossrefMedlineGoogle Scholar7. Tanner NC: Gastric and jejunal polyposis associated with melanin spots of oral region and digits, Proc. Roy. Soc. Med. 44: 406, 1951. MedlineGoogle Scholar8. SchafferSachs ABSW: The syndrome of generalized intestinal polyposis and melanin spots of the oral mucosa, lips and digits: a case report, Oral Surg., Oral Med. and Oral Path. 5: 271, 1952. CrossrefMedlineGoogle Scholar9. Wolf HH: Familial intestinal polyposis with pigmentation of lips, oral mucosa, face and digits, Lancet 1: 446, 1952. CrossrefMedlineGoogle Scholar10. Kitchin AP: Polyposis of small intestine with pigmentation of oral mucosa, Brit. M. J. 1: 4811, 1953. CrossrefGoogle Scholar11. KaplanFeuchtwanger IM: Recurrent intussusception due to polyposis of gastrointestinal tract associated with pigmentation, Brit. M. J. 1: 4811, 1953. CrossrefGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Ann Arbor, Michigan*Received for publication April 17, 1954.From the Thomas Henry Simpson Memorial Institute for Medical Research, University of Michigan, Ann Arbor, Michigan. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byGenetik der mit Pigmentstörungen einhergehenden DermatosenPEUTZ‐JEGHERS SYNDROME: A CASE REPORTFamilial intestinal polyposis with melanosis oris: The syndrome of Peutz and JeghersIntestinal polyposis with oral pigmentationHereditary small intestinal polyposis with intussusception and oral pigmentation in two generations: Peutz-Jeghers syndromeGastrointestinal Polyposis with Mucocutaneous Pigmentation (Peutz–Jeghers Syndrome)Intestinal Polyposis Associated with Mucocutaneous Melanin Pigmentation (Peutz-Jeghers Syndrome)Oral Melanin Pigmentation In Intestinal PolyposisINTESTINAL POLYPOSIS AND ORAL PIGMENTATION: CASE REPORT*ROLAND W. RICHTERICH-VAN BAERLE, M.D., W. W. BYRNES, M.D., MARSHALL G. MORRIS, M.D., SAUL SCHEFF, M.D.Treatment of multiple polyposis of the small intestineCurrent pediatric references 1 February 1955Volume 42, Issue 2Page: 424-432KeywordsMelaninMucous membranesTwins Issue Published: 1 February 1955 PDF downloadLoading ...