Calcium Pyrophosphate Dihydrate Crystal Deposition Disease: Nomenclature and Diagnostic Criteria
Authors: DANIEL J. MCCARTY
Journal: Annals of Internal Medicine (1977)

Editorials1 August 1977Calcium Pyrophosphate Dihydrate Crystal Deposition Disease: Nomenclature and Diagnostic CriteriaDANIEL J. MCCARTY, M.D.DANIEL J. MCCARTY, M.D.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-87-2-240 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe variety of names suggested for the condition associated with deposits of calcium pyrophosphate dihydrate crystals is exceeded only by the variations of its clinical presentation. "Articular chondrocalcinosis" was used by Zitňan and Sitaj to designate the highly characteristic articular radiodensities used by them as the definitive diagnostic feature (1). "Pseudogout" was first used by me in these pages 15 years ago because we had discovered microcrystals of calcium pyrophosphate dihydrate in the leukocytes of fluid from inflamed joints (2). These seemed analogous to the sodium urate crystals associated with true gout that we had described previously.Both the diagnosis...References1. ZITŇAN D and SITAJ S: Chondrocalcinosis polyarticularis (familiaris). Cesk Rentgenol 14:27-34, 1960 MedlineGoogle Scholar2. MCCARTY D, KOHN N, and FAIRES J: The significance of calcium phosphate crystals in the synovial fluid of arthritic patients: "the pseudogout syndrome." I. Clinical aspects. Ann Intern Med 56:711-737, 1962 LinkGoogle Scholar3. MCCARTY D, HOGAN J, and GATTER R: Studies on pathological calcifications in human cartilage. I. Prevalence and types of crystal deposits in the menisci of two hundred fifteen cadavera. J Bone Joint Surg [Am] 48:309-325, 1966 CrossrefMedlineGoogle Scholar4. ZITŇAN D SITAJ S : Natural course of articular chondrocalcinosis. Arthritis Rheum 19:363-390, 1976 CrossrefMedlineGoogle Scholar5. SILCOX D and MCCARTY D: Elevated inorganic pyrophosphate concentrations in synovial fluids in osteoarthritis and pseudogout. J Lab Clin Med 83:518-531, 1974 MedlineGoogle Scholar6. HOWELL D, MUNIZ O, and PITA J: Extrusion of pyrophosphate into extracellular media by osteoarthritis cartilage incubates. J Clin Invest 56:1473-1480, 1975 CrossrefMedlineGoogle Scholar7. MENKES C, SIMAS F, and CHOURAKI L: Les arthropathies destructices de la chondrocalcinose. Rev Rhum 40:115-123, 1973 MedlineGoogle Scholar8. JACOBELLI S, MCCARTY D, and SILCOX D: Calcium pyrophosphate dihydrate crystal deposition in neuropathic joints. Four cases of polyarticular involvement. Ann Intern Med 79:340-347, 1973 LinkGoogle Scholar9. RESNICK D, NIWAYAMA G, and GOERGEN T: Clinical, radiographic, and pathologic abnormalities in calcium pyrophosphate dihydrate (CPPD) deposition disease; pseudogout. Radiology 122:1-15, 1977 CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: DANIEL J. MCCARTY, M.D.Affiliations: Department of Medicine The Medical College of Wisconsin Milwaukee, Wisconsin PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byImaging Features of Calcium Pyrophosphate Deposition Disease: Consensus Definitions From an International Multidisciplinary Working GroupReliability and Diagnostic Accuracy of Radiography for the Diagnosis of Calcium Pyrophosphate Deposition: Performance of the Novel Definitions Developed by an International Multidisciplinary Working GroupWhich are the most frequently involved peripheral joints in calcium pyrophosphate crystal deposition at imaging? 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