tbuckley/cabot-search huggingface dataset:
Dislocation of Lens-Diagnosis by Ultrasonography
Authors: Michael B. Minix
Journal: JAMA (1969)

To the Editor:—  The first diagnostic uses of ultrasonography in ophthalmology were described by Mundt and Hughes in 1956 1 and Oksala in 1957. 2 Ultrasound has since been shown to be useful, diagnostically, in determining the axial length of the globe, localizing intraocular foreign bodies, and in identifying various intraocular and retrobulbar lesions.  The history, theory, and techniques of ocular ultrasonography have been reviewed. 3 Oksala first showed the value of ultrasound in the diagnosis of a posteriorly luxated lens 4 and explored the effects of the lens on the ultrasound field; these included dispersion, higher absorption, and higher velocity than the surrounding ocular structures. 5 He also demonstrated that multiple echoes may arise from a cataractous lens. 6   However, the ultrasonic diagnosis of anterior lens dislocation has not previously been reported. This may be of use when a cloudy cornea or anterior chamber make visual diagnosis difficult. This
Early Failure of the Diabetic Heart
Authors: Ida Gustafsson, Per Hildebrandt
Journal: Diabetes Care (2001)

That diabetes is a risk factor for congestive heart failure has been established for decades, but knowledge of the pathophysiology and treatment of heart failure in diabetes is limited. The prevalence of diabetes in different surveys and clinical trials of heart failure ranges from 10 to > 30% (1). In the community setting, data from the Framingham Heart Study have shown an increased incidence of congestive heart failure in diabetic subjects irrespective of coronary heart disease and hypertension (2). The relative impact of diabetes on developing heart failure was found to be greater in women. In the Studies of Left Ventricular Dysfunction (SOLVD) Trials and Registry, diabetes was found to be an independent risk factor for mortality and morbidity in both symptomatic and asymptomatic heart failure (3). A common finding in diabetic patients enrolled in clinical trials of myocardial infarction is a discrepancy between left ventricular systolic function and heart failure symptoms (4,5). Despite similar left ventricular systolic function, patients with diabetes have more pronounced heart failure symptoms, use more diuretics, and have an adverse prognosis compared with those without diabetes. One putative explanation for this discrepancy is diastolic dysfunction of the left ventricle.

In over heart failure, diastolic dysfunction often coexists with systolic dysfunction as a consequence of ischemic …
Comparison of two methods of administering bronchodilator aerosol to asthmatic patients.
Authors: Y F Choo-Kang, I W Grant
Journal: BMJ (1975)

In 78 patients with chronic asthma the increase in forced expiratory volume in one second (FEV-1) after the administration by intermittent positive-pressure ventilation (I.P.P.V.) of 10 mg of salbutamol was compared with that recorded after the inhalation of a conventional dose (200 mug) from a pressurized canister. The mean increase was significantly greater after I.P.P.V. administration, and the superiority of this method was greatest in patients with the lowest pretreatment FEV-1.
Effect of Glucagon on Gastric Secretion in the Dog
Authors: S. D. Clarke, D. W. Neill, R. B. Welbourn
Journal: Gut (1960)

The effects of glucagon on gastric secretion in the dog have been studied. Gastric juice was collected both from denervated and innervated pouches under basal conditions and when the animals were stimulated by meat extract and by histamine. In the dogs with innervated pouches psychic stimulation and the stimulatory action of insulin-induced hypoglycaemia were also used. Glucagon reduced the volume but not the acidity of gastric juice collected under all conditions. This effect was independent of its hyperglycaemic action and occurred when physiological doses were administered.
THE EFFECT OF LIGATION OF THE COMMON BILE DUCT ON CHOLESTEROL SYNTHESIS IN THE RAT
Authors: Donald S. Fredrickson, Alden V. Loud, Beverly T. Hinkelman, Henny S. Schneider, Ivan D. Frantz
Journal: The Journal of Experimental Medicine (1954)

The effect on cholesterol synthesis of ligation of the common bile duct was studied in the rat. The bile ducts of rats were ligated; 24 to 48 hours later, estimates of the rate of cholesterol synthesis were made, either by injection of labelled water or acetate into the intact animal, or by incubation of slices or homogenates of the liver in the presence of 1-C(14)-acetate. These various criteria all indicated that cholesterol synthesis was increased following ligation of the bile duct. The average ratios of the rate of synthesis in the experimental animals to that in the controls were as follows: 1. Synthesis from C(14)-carboxyl-labelled acetate: (a) in the intact rat fed ad libitum, 19; (b) in liver slices from the fasted rat, 23; (c) in liver slices from the rat fed ad libitum, 4; (d) in cell-free homogenates from the fasted rat, >27; (e) in cell-free homogenates from the rat fed ad libitum, 17. 2. Synthesis from tritium-labelled water in the intact rat fed ad libitum, 4.
Principles and Practice of Geriatric Surgery
Authors: Alejandra Perez-Tamayo
Journal: JAMA (2012)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
O8.05 * STRUCTURAL CHARACTERIZATION OF LOW GRADE GLIOMAS BY INTEGRATION OF MR, ULTRASOUND AND PET IMAGING
Authors: M. Riva, E. Lopci, F. Raneri, T. Alfiero, F. Pessina, A. Castellano, A. Falini, A. Chiti, L. Bello
Journal: Neuro-Oncology (2014)

Structural characterization of Low-Grade.Gliomas (LGGs) is depicted by MR or metabolic imaging, which when transferred into the neuronavigation system are used for guidance and tissue sampling. The combined use of intraoperative-Ultrasound-(US), corrects for brain shift. We present our experience on the use of MR, MET(methionine)-PET-TC, US for structural characterization of LGGs for surgical resection. Patients with presumptive MRl diagnosis of LGGs were submitted to standard, advanced MR (diffusion-tensor-structural-characterization-imaging), MET-PET-TC. images were transferred to neuronavigation system and available for guidance and tissue sampling. Intraoperative Aloka-US delineated tumor mass, corrected for brainshift, being a further source for structural characterization. The correspondence between information obtained by MR and MET-PET-TC was evaluated preoperatively. Intraoperatively sampling was performed according to MR and MET-PET information. Histological-molecular analysis (MGMT status, codeletion, IDH1) of various samples was performed. 139 patients were studied. Two groups were depicted by advanced-MR: 49 tumors (small-medium volume) with one-two areas of high-tissue-density (q areas); 90 tumors (medium-large volume), with several q areas. MET-PET-TC depicted areas of high-uptake in 39, a low activity in 72 and no activity in the remaining. The areas of high MET-uptake were located in the q areas. Multiple spots were present in larger tumors. At surgery, neuronavigation integrated with US was used to perform samples of various MR and/or PET areas. Areas of higher MET-uptake corresponded to anaplastic foci (35%) or higher tissue density areas (55%) with higher proliferative rate, or oligodendroglial tumors (34%). Samples taken from various MR or PET areas of the same tumor showed a differential molecular signature (IDH1, MGMT status). The integrated use of advanced-MR-imaging, MET-PET-TC, US better delineate structural characterization of LGGs, allowing a more precise histological-molecular profiling of the tumor.
Potential of Pretreatment Neural Activity in the Visual Cortex During Emotional Processing to Predict Treatment Response to Scopolamine in Major Depressive Disorder
Authors: Maura L. Furey, Wayne C. Drevets, Elana M. Hoffman, Erica Frankel, Andrew M. Speer, Carlos A. Zarate
Journal: JAMA Psychiatry (2013)

The need for improved treatment options for patients with major depressive disorder (MDD) is critical. Faster-acting antidepressants and biomarkers that predict clinical response will facilitate treatment. Scopolamine produces rapid antidepressant effects and thus offers the opportunity to characterize potential biomarkers of treatment response within short periods.
Case Management after Acute Myocardial Infarction
Authors: Michael Alderman
Journal: Annals of Internal Medicine (1994)

Letters1 November 1994Case Management after Acute Myocardial InfarctionMichael Alderman, MD and Douglas Shenson, MD, MPHMichael Alderman, MDSearch for more papers by this author and Douglas Shenson, MD, MPHSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-121-9-199411010-00018 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:The recent study by DeBusk and colleagues [1] is as important for its implications as for its findings. Their experiment confirms and extends observations repeatedly made over the past two decades: Nurses are vastly more successful at protocol-driven health promotion than are primary care physicians [1]. This finding should not be surprising, given that doctors are trained exclusively to diagnose and treat disease. Health promotion and prevention require a different set of skills and interests.What is new in their work is the conclusion that the old message applies to “managed care.” The Kaiser-Permanente Medical Clinics are ...References1. DeBusk DF, Houston Miller N, Superko HR, Dennis CA, Thomas RJ, Lew HT, et al. A case-management system for coronary risk factor modification after acute myocardial infarction. Ann Intern Med. 1994; 120:721-9. Google Scholar2. Alderman MH, Schoenbaum EE. Detection and treatment of hypertension at the work site. N Engl J Med. 1975; 293:65-8. Google Scholar Author, Article, and Disclosure InformationAffiliations: PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByGlobal Case Management 1 November 1994Volume 121, Issue 9Page: 720KeywordsAcute myocardial infarctionHealth maintenance organizationsHealth promotionHyperlipidemiaHypertensionMyocardial infarctionNursesPreventive medicinePrimary care physicians Issue Published: 1 November 1994 CopyrightCopyright © 1994 by American College of Physicians. All Rights Reserved.PDF DownloadLoading ...
Encephalitis of Unclear Origin Diagnosed by Brain Biopsy
Authors: Jeffrey M. Gelfand, Gillian Genrich, Ari J. Green, Tarik Tihan, Bruce A. C. Cree
Journal: JAMA Neurology (2014)

Brain biopsy specimens that exhibit encephalitis without specific histopathologic features pose a diagnostic challenge to neuropathologists and neurologists. Such cases are generally referred to pathologically as encephalitis, not otherwise specified (ENOS). A systematic approach to diagnostic evaluation in such patients is challenging, and currently there is no generally accepted algorithm.To examine ultimate diagnostic outcomes in patients with ENOS diagnosed by brain biopsy.This retrospective case series at the University of California, San Francisco, Medical Center, a tertiary care urban neurosciences center, studied patients with encephalitis diagnosed by brain biopsy from January 1, 1983, through December 31, 2011.Brain biopsy.Clinical and neuropathologic diagnosis.Among 58 patients who met the inclusion criteria for the study, the original pathologic diagnosis was ENOS in 49 patients (84%). The median age was 40 years (interquartile range, 27-53 years), 35 patients were male, and 13 had known human immunodeficiency virus or AIDS. Median time from onset of symptoms to brain biopsy was 66 days (interquartile range, 18-135 days). For the 29 patients in whom material for pathologic analysis was still available, additional neuropathologic review led to a more specific categorization in 10 (34%). Clinical detail and follow-up information was available for 42 patients, and a specific diagnosis was reached with the help of ancillary testing and/or clinical follow-up in 12 patients. Despite a comprehensive neuropathologic review with additional studies and information, 27 patients still had to be classified in the ENOS category at the end of the study.ENOS is the most common initial type of encephalitis diagnosed by brain biopsy. In such patients, it may be worth having the biopsy materials reviewed again in a comprehensive fashion by a neuropathologist because additional review led to a more specific categorization in one-third of our cases. Ancillary testing, clinical correlation, and clinical follow-up establish more specific diagnoses in some patients. ENOS still remains a diagnostic challenge after all these efforts in many cases. Current algorithms are of limited value. More advanced methods and better diagnostic algorithms are needed to characterize these patients.
Protection against nerve toxicity by monoclonal antibodies to the sodium channel blocker tetrodotoxin.
Authors: R I Huot, D L Armstrong, T C Chanh
Journal: Journal of Clinical Investigation (1989)

The sodium channel blocker, tetrodotoxin (TDT), was conjugated to keyhole limpet hemocyanin (KLH) and used to immunize BALB/c mice. Anti-TDT antibodies were detected in serum by ELISA and reached stable levels 4-5 wk after the first immunization. Spleens from immunized mice were fused with NS-1 mouse myeloma cells and approximately 9,329 resultant hybrids were screened by ELISA for reactivity to TDT. Two stable hybrids were isolated, subcloned, and characterized. These hybrids, termed TD13a1 and TD2C5, secreted specific anti-TDT antibodies that recognized TDT but not the related sodium channel blocker, saxitoxin (STX), as determined by competition ELISA. Both antibodies were of the IgG1k subclass with Ka's approaching 10(7) M-1. The inhibitory ability of these antibodies was tested by a competitive displacement assay for [3H]STX on rat brain membranes. Both antibodies strongly inhibited TDT binding to membranes. A nanomole of TD2C5 was able to bind approximately 1.8 nmol of TDT, whereas a comparable amount of TD13a1 bound half as much. Furthermore, TD2C5 was able to protect against TDT-induced reduction of peripheral nerve action potentials in rat tibial nerve when administered in situ. These antibodies thus represent potentially useful reagents for neurobiologic research, detection of toxin contamination and diagnosis of poisoning, and may provide protection against the toxicity of TDT in vivo.
Doctor accused of "interfering" in girl's treatment is cleared by GMC
Authors: C. Dyer
Journal: BMJ (2002)

A consultant paediatrician who disagreed with the parents of a girl with chronic fatigue syndrome about her treatment and obtained her medical records without their consent has been cleared of serious professional misconduct by the General Medical Council. The case resumed last week, having been adjourned in June (29 June, p 1539).

Christopher Cheetham, consultant paediatrician at Wycombe General Hospital, continued to involve himself in the case of the 12 year old girl after her parents, named only as Mr and Mrs B, made it clear they no longer wanted …
The effect of wavelength, power and treatment pattern on the outcome of laser treatment of port-wine stains
Authors: S. J. ADAMS, C. P. SWAIN, T. N. MILLS, S. G. BOWN, P. R. SALMON
Journal: British Journal of Dermatology (1987)

The argon laser was used to treat 220 patients with port‐wine stains with moderate efficacy and few complications although perfect cosmetic results were rarely achieved. Primary failure of the argon laser to produce permanent blanching graded good or excellent was the most important factor limiting the final cosmetic results whilst severe scarring was rare (< 2%). In order toimprove the efficacy of this treatment, a randomized controlled study of different parameters of laser treatment was undertaken in test patches of port‐wine stains in 50 patients. A treatment pattern with contiguous or overlapping laser spots was significantly superior to treatment with spots of 1 or 2 mm separation. Increasing the power level to twice the minimum blanching power did not improve efficacy or significantly increase scarring. A randomized study of selective absorption using a neodymium (Nd) YAG laser showed similar efficacy for the different wavelengths although scarring was greater with the Nd‐YAG laser. This study has shown that laser treatment can offer a moderately effective treatment for port‐wine stains. For best results spot separation needs to be carefully controlled, whilst wavelength and power level appear to be less important than previously reported.
Controlling gastric acid.
Authors: J N Hunt, T M Price
Journal: BMJ (1971)

It Selective vagotomy no pyloroplasty no stenosis _ O [ 2 ++ 3 -+ + + 4 0 0 0 5 + 0 0 6 + .00 ~7 0 !12 3 + + 0+ 0 0 14 0 15 ~+ 0 17 0 18 _ °O 0 14 0 0 0_ lb + O~+O_ 70 01 0 0 3 6 12 months afteroperation so long as nerve section is complete and the nerves of Latarjet properly preserved.It is a very much better operation than bilateral selective vagotomy without drainage for it can be used in the presence of organic duo- denal narrowing.Probably only in advanced duodenal stenosis is a drainage operation required.-Iam, etc.,
Paraneoplastic chorea: Case study with autopsy confirmation
Authors: Ivo W. Tremont-Lukats, Gregory N. Fuller, Teresa Ribalta, Pierre Giglio, Morris D. Groves
Journal: Neuro-Oncology (2002)

A 67-year-old man presented with a 7-month history of insidiously progressive chorea, ataxia, and vertigo. Neurologic examination revealed deficits referable to the basal nuclei, cerebellar vermis, and vestibular nuclei. Small-cell lung cancer was diagnosed by fine-needle biopsy of a parahilar mass. After chemotherapy, the patient's chorea worsened. Anti-Hu antibodies were present in serum and cerebrospinal fluid. Microscopic examination of the brain at autopsy revealed diffuse perivascular lymphocytic infiltrates, microglial activation, and neuronophagia throughout the neuraxis, including the brainstem, cerebellum, lenticular nuclei, striatum, and cerebral cortex. Prominent loss of Purkinje cells was seen in the cerebellar vermis and hemispheres to a lesser degree. Chorea is extremely rare as a paraneoplastic manifestation of cancer. The florid presentation and the positive findings contrasted with an unremarkable MRI of the brain. This case illustrates the preeminence of symptoms and signs over negative MRI findings in paraneoplastic encephalitis.
Mechanisms of Fibroblast Cell Therapy for Dystrophic Epidermolysis Bullosa: High Stability of Collagen VII Favors Long-term Skin Integrity
Authors: Johannes S Kern, Stefan Loeckermann, Anja Fritsch, Ingrid Hausser, Wera Roth, Thomas M Magin, Claudia Mack, Marcel L Müller, Oliver Paul, Patrick Ruther, Leena Bruckner-Tuderman
Journal: Molecular Therapy (2009)

Here, we report on the first systematic long-term study of fibroblast therapy in a mouse model for recessive dystrophic epidermolysis bullosa (RDEB), a severe skin-blistering disorder caused by loss-of-function of collagen VII. Intradermal injection of wild-type (WT) fibroblasts in >50 mice increased the collagen VII content at the dermal–epidermal junction 3.5- to 4.7-fold. Although the active biosynthesis lasted <28 days, collagen VII remained stable and dramatically improved skin integrity and resistance to mechanical forces for at least 100 days, as measured with a digital 3D-skin sensor for shear forces. Experiments using species-specific antibodies, collagen VII–deficient fibroblasts, gene expression analyses, and cytokine arrays demonstrated that the injected fibroblasts are the major source of newly deposited collagen VII. Apart from transitory mild inflammation, no adverse effects were observed. The cells remained within an area ≤10 mm of the injection site, and did not proliferate, form tumors, or cause fibrosis. Instead, they became gradually apoptotic within 28 days. These data on partial restoration of collagen VII in the skin demonstrate the excellent ratio of clinical effects to biological parameters, support suitability of fibroblast-based therapy approaches for RDEB, and, as a preclinical test, pave way to human clinical trials. Here, we report on the first systematic long-term study of fibroblast therapy in a mouse model for recessive dystrophic epidermolysis bullosa (RDEB), a severe skin-blistering disorder caused by loss-of-function of collagen VII. Intradermal injection of wild-type (WT) fibroblasts in >50 mice increased the collagen VII content at the dermal–epidermal junction 3.5- to 4.7-fold. Although the active biosynthesis lasted <28 days, collagen VII remained stable and dramatically improved skin integrity and resistance to mechanical forces for at least 100 days, as measured with a digital 3D-skin sensor for shear forces. Experiments using species-specific antibodies, collagen VII–deficient fibroblasts, gene expression analyses, and cytokine arrays demonstrated that the injected fibroblasts are the major source of newly deposited collagen VII. Apart from transitory mild inflammation, no adverse effects were observed. The cells remained within an area ≤10 mm of the injection site, and did not proliferate, form tumors, or cause fibrosis. Instead, they became gradually apoptotic within 28 days. These data on partial restoration of collagen VII in the skin demonstrate the excellent ratio of clinical effects to biological parameters, support suitability of fibroblast-based therapy approaches for RDEB, and, as a preclinical test, pave way to human clinical trials.
TGF-β1 induces proliferation in human renal fibroblasts via induction of basic fibroblast growth factor (FGF-2)
Authors: Frank Strutz, Michael Zeisberg, Anja Renziehausen, Birgit Raschke, Volker Becker, Cees Van Kooten, Gerhard A. Müller
Journal: Kidney International (2001)
Clinical Significance of the Philadelphia Chromosome in Chronic Granulocytic Leukemia.
Authors: George P. Canellos
Journal: Annals of Internal Medicine (1968)

Abstracts1 May 1968Clinical Significance of the Philadelphia Chromosome in Chronic Granulocytic Leukemia.Authors: George P. Canellos, M.D., Robert T. Eagan, Jacqueline Whang, M.D., and Paul P. Carbone, M.D.Author, Article, & Disclosure InformationPublication: Annals of Internal MedicineVolume 68, Number 5https://doi.org/10.7326/0003-4819-68-5-1166_2 Get AccessSubmit a CommentContributors must reveal any conflict of interest. Comments are moderated. Please see our information for authorsregarding comments on an Annals publication.Name (if multiple authors, separate names by comma)Name field is requiredComment TitleTitle field is requiredAffiliation & Institution (max characters: 200)Affiliations field is requiredCommentComment field is requiredPlease disclose any conflicts of interest or leave the box unchecked if you have noneDisclosure of Any Conflicts of InterestCancelSubmit