tbuckley/cabot-search huggingface dataset:
Insights From the NHLBI-Sponsored Women’s Ischemia Syndrome Evaluation (WISE) Study
Authors: C. Noel Bairey Merz, Leslee J. Shaw, Steven E. Reis, Vera Bittner, Sheryl F. Kelsey, Marian Olson, B. Delia Johnson, Carl J. Pepine, Sunil Mankad, Barry L. Sharaf, William J. Rogers, Gerald M. Pohost, Amir Lerman, Arshed A. Quyyumi, George Sopko
Journal: Journal of the American College of Cardiology (2006)
THE CARDIOVASCULAR MANIFESTATIONS OF INDUCED THYROTOXICOSIS; REPORT OF TWO CASES
Authors: H M ROGERS
Journal: Annals of Internal Medicine (1947)

Case Reports1 June 1947THE CARDIOVASCULAR MANIFESTATIONS OF INDUCED THYROTOXICOSIS; REPORT OF TWO CASESH. MILTON ROGERS, M.D., F.A.C.P.H. MILTON ROGERS, M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-26-6-914 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe occurrence of cardiovascular manifestations as results of induced thyrotoxicosis has not been commonly recorded. It is the purpose of this paper to report two cases in which the ingestion of excessively large doses of desiccated thyroid substance was associated with cardiovascular manifestations. The evidence to be presented leaves no reasonable doubt that these changes were the results of induced thyrotoxicosis.CASE REPORTSCase 1. The patient was a white female 63 years old, first examined on November 26, 1940. For two months previously dyspnea, which had increased in severity, had been observed. Palpitation, nervousness and tremor had been noted...Bibliography1. HURXTHAL LM: Experiences with the use of desiccated thyroid. Methods of detecting self-induced hyperthyroidism, with a report of a case in which auricular fibrillation occurred, New York State Jr. Med., 1944, xliv, 2217-2223. Google Scholar2. KEPLERBARNES EJAR: Congestive heart failure and hypertrophy in hyperthyroidism: a clinical and pathological study of 178 cases, Am. Heart Jr., 1932, viii, 102-108. CrossrefGoogle Scholar3. LIKOFFLEVINE WBSA: Thyrotoxicosis as the sole cause of heart failure, Am. Jr. Med. Sci., 1943, ccvi, 425-434. CrossrefGoogle Scholar4. ANDRUS EC: Clinical and experimental observations upon the heart in hyperthyroidism, Trans. Assoc. Am. Phys., 1932, lxvii, 47-54. Google Scholar5. MAHERSETTLER CCWW: The cardiovascular state in thyrotoxicosis, Jr. Am. Med. Assoc., 1936, cvi, 1546-1557. CrossrefGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: St. Petersburg, Florida*Received for publication July 11, 1946. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byTHE CARDIOVASCULAR SYSTEM IN THYROTOXICOSISIatrogenic Thyrotoxicosis. Causal Circumstances, Pathophysiology and Principles of Treatment. Review of the LiteratureFACTITIAL THYROTOXIC CRISIS INDUCED BY DEXTROAMPHETAMINE SULFATE AND THYROID*JOHN B. ATKINSON, M.D.Thyrotoxicosis factitia masked as heart disease 1 June 1947Volume 26, Issue 6Page: 914-919KeywordsAnxietyDyspneaIngestionThyroid ePublished: 1 December 2008 Issue Published: 1 June 1947 PDF downloadLoading ...
To Lao Tsu, From the Ward
Authors: Phil Bowman
Journal: JAMA (2003)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Association Between Nanobacteria and Periodontal Disease
Authors: Neva Çiftçioğlu, David S. McKay, E. Olavi Kajander
Journal: Circulation (2003)

To the Editor:Hung et al 1 recently reported that the association between periodontal disease and incident tooth loss and peripheral arterial disease (PAD) is probably mediated via the oral infectioninflammation pathway.Discussions on the same hypothesis have been continuing for many decades.But so far, no clear causeand-effect relationship has been found.Part of the link between these two diseases may be discovered through novel investigations of the opportunistic, infectious bacteria that colonize the mouth, form biofilm, cause periodontal disease, and activate white blood cells to release proinflammatory mediators that may contribute to heart disease and stroke.There are Ͼ300 species of known bacteria forming populations of several hundred billion in the human oral cavity.The number of bacteria reaches a thousand billion when the mouth is not sufficiently cleaned.Coronary atherosclerosis (CA) has been suggested to be an inflammatory disease in which chronic dental infections may trigger pathogenic mechanisms in the walls of arteries.Vascular calcification increases the severity of CA and is one of the biggest problems in this disease.Definitive mechanisms causing vascular calcification are unknown.Because nanobacteria (NB) form surface calcifications at physiological levels of calcium and phosphate, they have been hypothesized to mediate tissue calcifications. 2These self-replicating, biofilm-forming, tetracyclinesensitive 3 agents remain controversial because of apatite coat and resistance to extraction of their components by conventional methods. 2 Our preliminary work with 18 dental pulp stones, selected only by severity of the stone formation, indicated the presence of NB antigens in the demineralized stones. 4Furthermore, we found a high incidence of kidney stones and gallstones in the patient group and in their parents. 4A research group from the Mayo Clinic in Rochester, Minn, has recently detected NB in calcified carotid arteries, aortic aneurysms, and cardiac valves by using electron microscopy and immunohistochemical staining techniques. 5 Should the link between oral disease and heart disease be firmly established, future studies should focus on identifying the specific biological factors involved and transferring this knowledge to prevent disease.The model for modern infectious disease research is to systematically consider a variety of potential infectious agents.Because NB can be identified by using culture, monoclonal antibodies, and electron microscopy techniques, and because they were detected in both dental pulp stones and CA, NB should be considered a potential causative agent to be screened in related diseases.We propose that NB may provide a potential bridge between periodontal diseases and PAD.This relationship is worthy of further study.
Interaction between warfarin and oral terbinafine
Authors: J. Gantmacher, J. Mills-Bomford, T. Williams, J A Warwick, R J M Corrall, M F Clarke, H S Boardman
Journal: BMJ (1998)

EDITOR–Warwick and Corrall report on a patient whose international normalised ratio changed while she was receiving multiple drugs, including oral terbinafine and warfarin.1 The authors suggest that this was because of an interaction between warfarin and terbinafine, but the case is more complex than it seems. The patient was taking four other drugs besides terbinafine (glibenclamide, metformin, frusemide, and spironolactone), which may have been interacting with warfarin after its biotransformation by a number of cytochrome P -450 enzymes. In addition, warfarin may interact with many other compounds, including beverages, food supplements, food stuffs, and food additives.2

Both terbinafine and warfarin are metabolised by cytochrome P -450 2C9 subclass. Terbinafine, however, has a low potential to induce cytochrome P -450, as it does not affect the disposition or the metabolism of antipyrine.3 Also, a pharmacokinetic study of a single dose of warfarin in …
Abstract P372: Increased Aortic Arch Width is an Independent Predictor of Incident Adverse Cardiovascular Disease Events: The Framingham Heart Study
Authors: Michael L Chuang, Philimon Gona, Rebecca M Musgrave, Saadia Qazi, Caroline S Fox, Joseph M Massaro, Udo Hoffmann, Christopher J O'Donnell
Journal: Circulation (2015)

Background: The aortic arch “unfolds” (radius of curvature increases) with greater age and excess burden of cardiovascular disease (CVD) risk factors. Aortic arch width (AAW, defined as the distance between the centroids of the ascending and descending aorta at the level of the main pulmonary artery bifurcation) is a simple, easily obtained measure of aortic geometry. We sought to determine whether AAW is an independent predictor of future adverse CVD events.

Methods: 3026 (1560 men) Framingham Offspring and Third Generation cohort members underwent thoracic multidetector computed tomography (MDCT) 2002-2005 and had complete risk factor profiles for analysis. AAW was measured by a single observer unaware of participant characteristics. Interobserver reproducibility for AAW was assessed in 100 participants. Adverse CVD events following MDCT were adjudicated by a panel of three physicians blinded to MDCT results. Incident CVD events included CVD death, myocardial infarction (MI), coronary insufficiency (CI), cerebrovascular accident (CVA), and index hospital admission for congestive heart failure (CHF-ia). Multivariable Cox proportional hazards models were used to determine the hazard of an adverse CVD event per 10mm of AAW, after adjustment for age, sex, smoking, systolic blood pressure, diabetes, total and HDL cholesterol.

Results: Mean ages of study participants were 50±11y for men and 52±10y for women. Mean AAW was 79±12mm in men and 70±10mm in women, p<0.0001. AAW measurement was highly reproducible (intraclass correlation coefficient=0.985). Over median 8.9-year follow-up there were 135 (4.5%) incident CVD events, including 49 MI (36%), 4 CI (3%), 42 CVA (31%), 34 CHF-ia (25%) and 6 CVD deaths (4%). Multivariable-adjusted Cox models indicated that greater AAW was associated with increased hazard of an incident CVD event (hazard ratio, HR=1.23/10mm; 95% confidence intervals, CI=1.04-1.46) after adjustment for age, sex and other CVD risk factors.

Conclusions: In a community-dwelling sample of middle-aged and older adults increased aortic arch width was an independent predictor of incident adverse CVD events over 8.9-year follow up. AAW is an easily performed and highly reproducible simple summary measure of aortic arch geometry that can be obtained from thoracic CT scans performed for clinical indications. Future studies are warranted to define the potential clinical value of AAW.
Abstract 3612: Myocardial Protection With a Novel Organ Preservation Solution Containing Deuterium Oxide for Prolonged Cold Ischemia of the Heart
Authors: Kenji Wakayama, Moto Fukai, Kenichiro Yamashita, Daisuke Fukumori, Susumu Shibasaki, Gentaro Hirokata, Tetsu Oura, Ryoichi Goto, Masahiko Taniguchi, Tomomi Suzuki, Tsuyoshi Shimamura, Hiroyuki Furukawa, Michitaka Ozaki, Satoru Todo
Journal: Circulation (2009)

Objective: Cold preservation of the heart using UW solution is limited to 4 – 6 hours. This is mainly due to ischemia and subsequent reperfusion injury that result in cardiomyocyte destruction by b...
Abstract P199: Keep Moving, Your Health Depends On It: Impact Of Improved Physical Activity And Weight Loss In A Wellness Program
Authors: Ebenezer T Oni, Ehimen Aneni, Maribeth Rouseff, Thinh Tran, Henry Guzman, Sankalp Das, Doris Brown, Joann Santiago-Charles, Teresa Ochoa, Joseph Mora, Cynthia Gilliam, Virginia Lehn, Beatriz Castillo, Lara Roberson, Emir Veledar, Theodore Feldman, Arthur S Agatston, Janisse Post, Khurram Nasir
Journal: Circulation (2014)

Negative impact of CVD as the leading cause of death in the US is worsened by the significant burden of obesity and associated morbidity and concerns about the growing population inactivity. The American Heart Association has emphasized worksite-based interventions to improve CV health. We evaluated the benefits of improved physical activity(PA) and weight loss(WL) among employees of the Baptist Health South Florida enrolled in a wellness intervention program. Methods: Employees with two or more Cardio-metabolic risk factors , such as total cholesterol ≥ 200 mg/dl, systolic blood pressure ≥ 140 mmHg or diastolic blood pressure ≥ 90 mmHg, hemoglobin A1C ≥ 6.5%, and body mass index (BMI) ≥ 30 were enrolled in an intervention program themed “My unlimited potential”. Interventions were focused on diet and PA modifications. We defined improved physical activity as the difference in the metabolic equivalents (METs) at 12 weeks follow-up and at baseline. WL (lbs) was the difference in weight at follow-up. The relationship between WL and changes in METs was explored in an ordered logistic regression. Results: Overall 203 (48±10 years, 78% females) employees were enrolled with a retention rate of 89% (n=181) at 12 weeks follow-up. At baseline the median weights was 211 lbs., and mean METs- 8.6, while at follow-up the median weight was 200 lbs, and the mean METs 11. At 12 weeks follow up 38% had significant WL (lost &gt;5% of baseline weight). The median WL was 8.4 (IQR 4.8-13.0) lbs and the mean change in METs was 2.4±1.8. Median WL increased with increasing tertiles of METs change; tertile1- 6.5(4-11) lbs., tertile2- 9(6-13)lbs. tertile3- 11(7-15)lbs. Increased PA was related to increased WL across BMI categories adjusting for age, gender and baseline weight. Conclusion: This study points strongly toward the benefit of increasing PA among other lifestyle modification interventions in controlling weight. Although further follow-up of this population to evaluate sustainability of change is needed, our results clearly relate improved PA and health.
Abstract 4212: ADAM10/Kuzbanian is upregulated during neuroendocrine prostate carcinogenesis
Authors: Brian D. Shannon, Laurie E. Littlepage
Journal: Cancer Research (2014)

Abstract Prostate cancer (CaP) is the second leading cause of cancer death in men. Advanced prostate tumors often contain neuroendocrine differentiation, which correlates with androgen-independent progression and poor prognosis. Currently, androgen deprivation is the first line of therapy for metastatic CaP. However, CaP often progresses to an androgen-independent bone-metastatic stage, at which point chemotherapy and radiotherapy become the primary therapeutic options. Despite recent advances in therapeutic strategies, many cancers still develop resistance to radiation and therapies, making the identification of new therapies essential to improve the lives and survival rates of patients. We have studied neuroendocrine cancer progression in the cryptdin-2 SV40-TAg (CR2-TAg) mouse model of CaP. Since these cancers do not express androgen receptor, they are refractory to androgen therapy. Therefore, we sought new potential targets. We previously found that matrix metalloproteinases (MMPs), which are capable of degrading many extracellular matrix proteins and cell surface receptors, are upregulated during CR2-Tag tumor progression. In the present study, we examined expression of a family of a disintegrin and metalloproteinases (ADAMs) that is actively involved in these signaling pathways due to their role in releasing the extracellular domain of transmembrane proteins. ADAMs contain features of both adhesive proteins and proteinases. ADAM10 activates the epidermal growth factor receptor (EGFR) and NOTCH signaling systems controlling cell growth, invasion, and metastasis. We found that ADAM10 expression increased during tumor progression and was highly penetrant. We are quantifying the expression levels and localization patterns of ADAM10 in these samples over time. Since MMPs, like ADAMs, are capable of degrading many extracellular matrix proteins and cell surface receptors, we determined if MMPs (MMP 2, 7, and 9) contribute to ADAM10 expression or localization in aggressive hormone refractory CaP. We have stained for ADAM10 in tissue sections from the CR2-TAg mice that are each missing expression of MMPs to determine if that particular MMP contributes to ADAM10 expression or localization. Our research using ADAM10 localization as a potential biomarker and therapeutic target has potential clinical value to identify aggressive CaP earlier in patients. Our study of MMPs and their role in ADAM10 expression will offer insight into the mechanisms of advanced prostate tumor progression. Note: This abstract was not presented at the meeting. Citation Format: Brian D. Shannon, Laurie E. Littlepage. ADAM10/Kuzbanian is upregulated during neuroendocrine prostate carcinogenesis. [abstract]. In: Proceedings of the 105th Annual Meeting of the American Association for Cancer Research; 2014 Apr 5-9; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2014;74(19 Suppl):Abstract nr 4212. doi:10.1158/1538-7445.AM2014-4212
Carbon Monoxide Poisoning, Myocardial Injury, and Mortality
Authors: Gar Ming Chan
Journal: JAMA (2006)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Liver Biopsy. An Atlas of Histologic Appearances.
Authors: H. Spencer
Journal: Annals of Internal Medicine (1962)

This modestly priced volume is principally concerned with developmental information, its storage in the fertilized egg, its encoding during the formation of the egg and its decoding during development.An attempt is made to estimate the amounts of information carried in the nucleus, cytoplasm and cortical field and total developmental information which may be considered as redundant.In considering the problems involved the author ranges over a wide field, touching on both vertebrate and invertebrate development.There are sections on oogenesis, egg membranes, the nucleus, nucleoli, cytoplasmic inclusions and nurse cells.Their morphology, biochemistry, histochemistry and electron microscopy receive consideration in appropriate places with, here and there, excursions into experimental embryology.The synthetic and metabolic activities of the oocyte are discussed as are the interactions between nucleus and cytoplasm, the relationship of the nucleolus to the chromosomes and cytoplasm and the interrelationships of the oocyte and its environment.The book contains a fund of information, presented in a stimulating manner.It should be on the shelves of all serious minded embryologists and should be read by all advanced students of the subject.
The Internal Secretory Organs: Their Physiology and Pathology.
Authors: Artur Biedl, Leonard Williams, Linda Forster
Journal: JAMA (1913)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
OSW-1 induces calcium-dependent apoptosis: Involvement of mitochondria and endoplasmic reticulum
Authors: Celia Garcia-Prieto, Geetha Achanta, Yan Zhou, Weiqin Lu, Zhao Chen, Yumin Hu, Zhendong Jin, Peng Huang
Journal: Cancer Research (2006)

Proc Amer Assoc Cancer Res, Volume 47, 2006

4702 

OSW-1 is a natural compound found in the bulbs of Orninithogalum saudersiae. This compound exhibits potent antitumor activity in vitro with the IC50 values in the sub-nM concentration range. Previous studies showed that OSW-1 are effective in killing various cancer cells including pancreatic cancer cells and primary leukemia cells resistant to standard chemotherapeutic agents, and that non-malignant cells were less sensitive to this compound. The current study was undertaken to determine the biochemical and molecular mechanisms of action of OSW-1. Electron microscopic analysis revealed that OSW-1 treatment caused significant damage to the mitochondrial membranes and severe swelling of the endoplasmic reticulum (ER) in human leukemia cells and pancreatic cancer cells. Biochemical assays showed that this compound induced a significant increase in cytosolic calcium as early as several hours after the drug incubation, and a subsequent activation of calcium-dependent apoptosis. Additionally, OSW-1 treatment appeared to result in mobilization of calcium into the mitochondria, and inhibition of mitochondrial calcium uptake led to further increase of cytosolic calcium and a decrease in cell death. Interestingly, the mitochondrial deficient rho-0 cells did not show increase in cytosolic calcium after OSW-1 treatment, and were significantly less sensitive to OSW-1, suggesting that mitochondria may be involved in the cytotoxic action of this compound. Furthermore, OSW-1 treatment also induced an initial increase of GRP78, an ER chaperone molecule known to promote cell survival and drug resistance, at the early time point (4 h), and a dramatic degradation of GRP78 as the drug incubation prolonged (16 h). Degradation of GRP78 and cell dead appeared to be a calcium-dependent event, since co-incubation of OSW-1 with BAPTA-AM, a cell permeable calcium chelator, prevented GRP78 degradation and significantly suppressed cell death. Taken together, these results suggest that OSW-1 exerts its cytotoxic activity through damaging mitochondria and ER, disrupting calcium homeostasis, and triggering calcium-dependent apoptotic pathway.