ELECTRONMICROSCOPIC STUDIES OF REVERSIBLE GLOMERULAR LESIONS IN THE ADULT NEPHROTIC SYNDROME
Authors: G FOLLI, V E POLLAK, R T REID, C L PIRANI, R M KARK
Journal: Annals of Internal Medicine (1958)

Article1 October 1958ELECTRONMICROSCOPIC STUDIES OF REVERSIBLE GLOMERULAR LESIONS IN THE ADULT NEPHROTIC SYNDROMEGIUSEPPE FOLLI, M.D., VICTOR E. POLLAK, M.B., M.R.C.P.E., Ross T. W. REID, M.D., CONRAD L. PIRANI, M.D., ROBERT M. KARK, F.A.C.P., F.R.C.P.GIUSEPPE FOLLI, M.D., VICTOR E. POLLAK, M.B., M.R.C.P.E., Ross T. W. REID, M.D., CONRAD L. PIRANI, M.D., ROBERT M. KARK, F.A.C.P., F.R.C.P.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-49-4-775 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe nephrotic syndrome is associated with a number of disease processes, which produce a variety of pathologic lesions in the kidney. The histology of many of these disease processes, including amyloidosis, lupus nephritis, proliferative glomerulonephritis with epithelial crescents, and renal vein thrombosis, is well known and widely accepted. On the other hand, the histologic distinction between lipoid nephrosis and membranous glomerulonephritis is still the subject of controversy. Few now agree with Munk's original description of the pathology of lipoid nephrosis,1namely, fatty changes in the tubules and—at least by light microscopy—normal glomeruli. Many agree with Allen2that ". . ....Bibliography1. Munk F: Pathologie und Klinik der Nephrosen, Nephritiden und Schrumpfnieren, 1918, Urban and Schwarzenberg, Berlin. Google Scholar2. Allen AC: The kidney: medical and surgical diseases, 1951, J. and A. Churchill, London. Google Scholar3. KarkPiraniPollakMuehrckeBlainey RMCLVERCJD: The nephrotic syndrome in adults: a common disorder with many causes, Ann. Int. Med. 49: 751, 1958. LinkGoogle Scholar4. 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Reid RT: Electronmicroscopy of glomeruli in nephrotoxic serum nephritis, Australian J. Exper. Biol. and M. Sc. 32: 235, 1954. CrossrefMedlineGoogle Scholar11. Rhodin J: Electron microscopy of the glomerular capillary wall, Exper. Cell. Res. 8: 572, 1955. CrossrefMedlineGoogle Scholar12. Rhinehart JF: Fine structure of renal glomerulus as revealed by electron microscopy, Arch. Path. 59: 439, 1955. Google Scholar13. Yamada E: Fine structure of the renal glomerulus of the mouse, J. Histochem. and Cytochem. 3: 309, 1955. CrossrefMedlineGoogle Scholar14. GershCatchpole IHR: The organization of ground substance and basement membrane and its significance in tissue injury, disease and growth, Am. J. Anat. 85: 458, 1949. CrossrefGoogle Scholar15. Hall BV: Personal communication, 1957. Google Scholar16. KarkMuehrckePiraniPollak RMRCCLVE: The clinical value of renal biopsy, Ann. Int. Med. 43: 807, 1955. LinkGoogle Scholar17. PollakKarkPiraniSoothillMuehrcke VERMCLJFRC: The significance and potential value of renal biopsy in Bright's disease, J. Chron. Dis. 5: 67, 1957. CrossrefMedlineGoogle Scholar18. BjørneboeBrunGormsenIversenRaaschou MCHPF: The nephrotic syndrome. I. Histological changes illustrated by means of biopsy of the kidney, Acta. med. Scandinav., Suppl. 266: 233, 1952. Google Scholar19. Joske RA: A technique for aspiration biopsy of the kidney, Australasian Ann. Med. 3: 44, 1954. CrossrefMedlineGoogle Scholar20. RossRoss JHIP: The value of renal biopsy, Lancet 2: 559, 1957. CrossrefGoogle Scholar21. PielWilliams CGF: Long continued adrenal hormone therapy in childhood nephrosis, J. Am. M. Women's A. 12: 273, 1957. MedlineGoogle Scholar22. FarquharVernierGood MGRLRA: Studies on familial nephrosis. II. Glomerular changes observed with the electron microscope, Am. J. Path. 33: 791, 1957. MedlineGoogle Scholar23. FolliPollakReidPiraniKark GVERTCLRM: Electronmicroscopic studies of renal biopsies taken from nephrotic patients before and after diuresis, J. Lab. and Clin. Med. 50: 813, 1957. Google Scholar24. Atchley DW: The nephroses, in Textbook of Medicine by Cecil, R. L., and Loeb, R. F., 1951, W. B. Saunders, Philadelphia. Google Scholar25. Ellis A: Natural history of Bright's disease. Clinical, histological and experimental observations, Lancet 1: 1, 1942. CrossrefGoogle Scholar26. Allen AC: The clinicopathologic meaning of the nephrotic syndrome, Am. J. Med. 18: 277, 1955. CrossrefMedlineGoogle Scholar27. EhrichFormanSeifter WECWJ: Diffuse glomerular nephritis and lipid nephrosis, Arch. Path. 54: 463, 1952. MedlineGoogle Scholar28. Bell ET: Renal diseases, 2nd Ed., 1950, Lea & Febiger, Philadelphia. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: *Presented in part at the Thirty-ninth Annual Session of The American College of Physicians, Atlantic City, New Jersey, April 29, 1958.From the Departments of Medicine, Presbyterian, Cook County and Research and Educational Hospitals, and the Departments of Pathology and Medicine of the University of Illinois College of Medicine, Chicago, Illinois.This work was supported in part by grants from the U. S. Public Health Service, National Institutes of Health, Bethesda, Maryland (H-2253(C)); and the Office of the Surgeon-General, U. S. Army (DA-49-007-MD-637). In addition, Dr. Reid's work was supported during the period of his appointment as Research Associate in the Department of Pathology at the University of Illinois by a special Grant-In-Aid from the U. S. Public Health Service, National Institutes of Health, Bethesda, Maryland (H-2253(C), Supplement). Dr. Folli was a Research Assistant in the Department of Medicine when this work was done.Requests for reprints should be addressed to Robert M. Kark, M.D., Presbyterian-St. Luke's Hospital, 1753 West Congress Street, Chicago 12, Illinois. 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KARK, F.A.C.P., F.R.C.P. (Lond.), CONRAD L. PIRANI, M.D., VICTOR E. POLLAK, M.B., M.R.C.P.E., ROBERT C. MUEHRCKE, M.D., JOHN D. BLAINEY, M.D., M.R.C.P. 1 October 1958Volume 49, Issue 4Page: 775-795KeywordsEdemaElectron microscopyGlomerulonephritisHospital medicineLesionsLupus nephritisMedical servicesRenal diseasesResearch laboratoriesVeins ePublished: 1 December 2008 Issue Published: 1 October 1958 PDF downloadLoading ...