A Study of Bacillus Calmette-Guérin Vaccination and the Kveim Reaction
Authors: HAROLD L. ISRAEL
Journal: Annals of Internal Medicine (1966)

Article1 January 1966A Study of Bacillus Calmette-Guérin Vaccination and the Kveim ReactionHAROLD L. ISRAEL, M.D., F.A.C.P., MAURICE SONES, M.D., F.A.C.P.HAROLD L. ISRAEL, M.D., F.A.C.P.Search for more papers by this author, MAURICE SONES, M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-64-1-87 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptA majority of patients with active sarcoidosis develop a granulomatous nodule within 6 weeks of the intracutaneous injection of suspensions prepared from spleens or lymph nodes involved by sarcoidosis. Clinical use of the Kveim reaction as a diagnostic test has been limited by difficulties in preparation and biologic standardization that seriously restrict the availability of test materials, by a hazard of deterioration resulting in loss of potency or of specificity, and by the fact that a significant number of patients with active sarcoidosis fail to react to suspensions of unquestioned potency. The Kveim reaction is nevertheless of basic importance, apparently...References1. HARTMITCHELLSUTHERLAND PDDNI: Associations between Kveim test results, previous B.C.G. vaccination, and tuberculin sensitivity in healthy young adults. Brit. Med. J. 1: 795, 1964. CrossrefMedlineGoogle Scholar2. ISRAELSONESSTEINARONSON HLMSCJD: B.C.G. vaccination in sarcoidosis. Amer. Rev. Tuberc. 62: 408, 1950. Google Scholar3. BRUNPERRIN-FAYOLLE JM: Allergie tuberculinique et B.C.G. dans la sarcoïdose. Bull. Soc. Med. Hop. Paris 115: 599, 1964. MedlineGoogle Scholar4. SILTZBACH LE: The Kveim test in tuberculosis, beryllium disease, leprosy and sarcoidosis. Amer. Rev. Resp. Dis. 90: 308, 1964. Google Scholar5. GROTH-PETERSONKNUDSENWILBEK EJE: Epidemiological basis of tuberculosis eradication in an advanced country. Bull. WHO 21: 5, 1959. MedlineGoogle Scholar6. BURNET M: The Clonal Selection Theory of Acquired Immunity. Vanderbilt University Press, Nashville, 1959, p. 163. CrossrefGoogle Scholar7. SCADDING JG: Calcification in sarcoidosis. Tubercle 42: 121, 1961. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Philadelphia, PennsylvaniaFrom the Sarcoidosis Clinic, Jefferson Medical College, Philadelphia, Pa.This study was supported by a grant from the Anthracite Health and Welfare Fund.Requests for reprints should be addressed to Harold L. Israel, M.D., Jefferson Medical College, Philadelphia, Pa. 19107. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byImmunity and Allergy in SarcoidosisProduction of uranium ore in capitalist countriesThe Kveim test in leprosyThe Diagnosis of SarcoidosisHAROLD L. ISRAEL, M.D., F.A.C.P. 1 January 1966Volume 64, Issue 1Page: 87-91KeywordsBacillusBiologicsBiopsyLymph nodesSarcoidosisSpecificitySpleenVaccines ePublished: 1 December 2008 Issue Published: 1 January 1966 PDF downloadLoading ...