A REVIEW OF WERNER'S SYNDROME, WITH A REPORT OF THE SECOND AUTOPSIED CASE
Authors: J K PERLOFF, E T PHELPS
Journal: Annals of Internal Medicine (1958)

Article1 June 1958A REVIEW OF WERNER'S SYNDROME, WITH A REPORT OF THE SECOND AUTOPSIED CASEJOSEPH K. PERLOFF, M.D., ELBERT T. PHELPS, M.D., F.A.C.P.JOSEPH K. PERLOFF, M.D., ELBERT T. PHELPS, M.D., F.A.C.P.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-48-6-1205 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptIn 1868 Rothmund1 published his observations on "Cataracts in Association with a Peculiar Degeneration of the Skin," a heredofamilial disorder found in the consanguineous populations of three small Bavarian villages. Thirty-six years later another German ophthalmologist, Werner,2 independently described an odd syndrome entitled "Cataract in Connection with Scleroderma," involving two sisters in a family of six siblings.Further observations were not published until material from German and French sources appeared in the 1920's. However, no distinction between these two syndromes was made until the first report in the American medical literature in 1934, when Oppenheimer and Kugel3distinguished the conditions...Bibliography1. Rothmund A: Über Katarakt in Verbindung mit einer eigentümlichen Hautdegeneration, Arch. f. Ophth. 14: 159, 1868. Google Scholar2. Werner CW: Über Katarakt in Verbindung mit Sklerodermie, 1904, Schmidt & Klaunig, Kiel. Google Scholar3. OppenheimerKugel BSVH: Werner's syndrome, Tr. A. Am. Physicians 49: 358, 1934. Google Scholar4. Thannhauser SJ: Werner's syndrome (progeria of the adult) with Rothmund's syndrome; two types of closely related heredofamilial atrophic dermatoses with juvenile cataracts and endocrine features; a critical study with five new cases, Ann. Int. Med. 23: 559, 1945. LinkGoogle Scholar5. Vidal E: Du lichen (lichen, prurigo, strophulus), Ann. de dermat. et syph. 7: 131, 1886. Google Scholar6. Andogsky N: Cataracta Dermatogenes, Klin. Monatsbl. f. 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RAISZ, M.D. 1 June 1958Volume 48, Issue 6Page: 1205-1220KeywordsArthritisCataractsDysplasiaEndocrinologyGenetic determinismOsteoporosisPathologistsPopulation statisticsSclerodermaUlcers ePublished: 1 December 2008 Issue Published: 1 June 1958 PDF downloadLoading ...