tbuckley/cabot-search huggingface dataset:
DNA-protein complexes induced by chromate and other carcinogens.
Authors: M Costa
Journal: Environmental Health Perspectives (1991)

DNA-protein complexes induced in intact Chinese hamster ovary cells by chromate have been isolated, analyzed, and compared with those induced by cis-platinum, ultraviolet light, and formaldehyde. Actin has been identified as one of the major proteins complexed to DNA by chromate based upon its molecular weight, isoelectric point, positive reaction with an actin polyclonal antibody, and proteolytic mapping. Chromate and cis-platinum both complex proteins of similar molecular weight and isoelectric points, and these complexes can be disrupted by chelating agents and sulfhydryl reducing agents, suggesting that the metal itself is participating in binding rather than having a catalytic or indirect role (i.e., oxygen radicals). In contrast, formaldehyde complexed histones to the DNA, and these complexes were not disrupted by chelating or reducing agents. An antiserum raised to chromate-induced DNA-protein complexes reacted primarily with 97,000 kDa protein that did not silver stain. Slot blots, as well as Western blots, were used to detect formation of p97 DNA crosslinks. This protein was complexed to the DNA by all four agents studied.
Dictionary of Medical Syndromes
Authors: Harvey N. Mandell
Journal: JAMA (1990)

Here is a feast for lovers of the eponymous and the obscure, and for any physician who has just received a report from a consultant advising that his or her patient has a classical case of Griesinger's syndrome. Magalini, Magalini, and de Francisci have compiled and alphabetized 2700 syndromes, providing them with synonyms, symptoms, signs, etiology, prognosis, and short bibliographies. The abecedarian arrangement of the syndromes stretches from Aagenaes' all the way to Zuelzer-Ogden (the latter, unfortunately, now labeled obsolete). How many readers know what Zoon's syndrome is or the difference between Rosenthal-Kloepfer, Rosenthal's (C.), and Rosenthal's (R.L.) syndromes? Some appellations are more descriptive than eponyms. For instance, Monday fever is what happens in patients with byssinosis when returning to work on Monday morning in a place with a high concentration of industrial cotton dust. If you can't identify mongolian blue spots, you should get this book and look them
Book Review Soft Tissue Sarcomas: New developments in the multidisciplinary approach to treatment (Cancer Treatment and Research. [56].) Edited by H.M. Pinedo, J. Verweij, and H.D. Suit. 173 pp., illustrated. Boston, Kluwer, 1991. $97.50.
Authors: F. Kristian Storm
Journal: New England Journal of Medicine (1992)
Blood Pressure Studies in Rural and Urban Groups in Delhi
Authors: S. PADMAVATI, SAVITRI GUPTA
Journal: Circulation (1959)

Very little data exist about blood pressure levels in Indians although it is generally believed that they are lower than among Western peoples. There also seems to be an impression that hypertension is rarer among poor Eastern populations. This study was carried out on 1,132 persons of poor economic status and 224 persons of good social class in Delhi. The results showed some striking differences between the two groups and from Western figures. Factors influencing the blood pressure levels, such as age and body weight, were also evaluated.
Novel Interleukin-13 Peptide-based Vaccine Downregulates Murine Allergic Airway Responses
Authors: Z. Peng, Y. Ma, Y. Fan, G. Srinivasan, X. Yang, A. Becker, F.E.R. Simons, K.T. HayGlass
Journal: Journal of Allergy and Clinical Immunology (2006)
PET/CT Characterization and Monitoring of Disease Activity in Lymphomatoid Granulomatosis
Authors: Michael C. Roarke, Ba D. Nguyen
Journal: Clinical Nuclear Medicine (2007)

An otherwise healthy, athletic 39-year-old woman presented with a nagging cough. Chest radiograph and CT revealed innumerable bilateral pulmonary nodules up to 1.5 cm in diameter. Video thoracoscopy and biopsy of the right middle and lower lobes were performed. Pathologic diagnosis was lymphomatoid granulomatosis. PET/CT was requested for baseline characterization before rituximab therapy.
Chronic Hepatitis D: A Vanishing Disease? An Italian Multicenter Study
Authors: Giovanni B. Gaeta, Tommaso Stroffolini, Maria Chiaramonte, Tiziana Ascione, Gianfranca Stornaiuolo, Salvatore Lobello, Evangelista Sagnelli, Maurizia R. Brunetto, Mario Rizzetto
Journal: Hepatology (2000)

Hepatitis delta virus (HDV) was responsible for a high proportion of cases of acute and chronic liver disease in Southern Europe during the 1970s. Some data suggest that by the 1990s HDV circulation had substantially declined. We have assessed the prevalence of HDV infection and its clinical impact in 834 Italian hepatitis B surface antigen (HBsAg) carriers in 1997. Anti-HDV antibodies were sought in all consecutive chronic HBsAg carriers observed in 14 referral liver units throughout Italy. Risk factors for anti-HDV positivity were evaluated. Anti-HDV antibodies were found in 69 of 834 (8.3%) HBsAg-positive patients. Cohabitation with an anti-HDV-positive subject, intravenous drug addiction, residence in the South of the country, and the presence of cirrhosis were independently associated with the presence of anti-HDV antibodies. The overall prevalence of anti-HDV antibodies was lower than those observed in 2 multicenter surveys performed in 1987 and 1992 (23% and 14%, respectively). By 1997, the percentage of anti-HDV-positive subjects had sharply decreased in the 30 to 50 years age group, whereas it was almost unchanged in subjects over 50 years of age. The highest prevalence of anti-HDV antibodies (11.7%) was found in patients with cirrhosis. This prevalence was as high as 40% in the 1987 study. The circulation of HDV sharply decreased in Italy, by 1.5% per year, from 1987 to 1997. This decrease resulted mainly from the reduction in chronic HDV infections in the young, for whom high morbidity and mortality rates were recorded in the past. The results anticipate the almost complete control of HDV infection in the near future.
Medical Intensive Care in the Teaching Hospital: Costs Versus Benefits
Authors: PAUL F. GRINER
Journal: Annals of Internal Medicine (1973)

In the teaching hospital, improved patient care, education, and research are anticipated outcomes of intensive care units. Finite resources dictate the examination of these benefits in relation to costs. Costs include not only the direct and indirect (overhead) expenses of an intensive care unit but also of ancillary services, such as laboratory tests. Studies of the effectiveness of intensive care have been limited mainly to comparison of mortality among patients with myocardial infarction receiving treatment in intensive versus conventional care settings. Studies of outcome of intensive care for other well-defined illnesses are in order that include other indexes, such as complications and functional status and mortality over an extended period after hospital discharge. The benefits of research and education in the intensive care setting should be evaluated. Only marginal improvement in the outcome of intensive care for selected conditions may still justify it if significant gains in education or research gains can be shown.
No Initial Therapy for Stage III and IV Non-Hodgkin's Lymphomas of Favorable Histologic Types
Authors: CAROL S. PORTLOCK
Journal: Annals of Internal Medicine (1979)

The question of whether initial treatment is necessary in relatively asymptomatic patients with stage III and IV non-Hodgkin's lymphomas of favorable histologic types was studied by retrospective analysis. Two groups of patients were studied: [1] 44 nonprotocol patients, followed since 1963, in whom initial treatment was withheld until required to evaluate the pace of disease and the necessity of treatment; and [2] 112 previously untreated patients who have participated in prospectively randomized clinical trials since 1971. For all 44 "deferred" patients, the median time before requiring treatment was 31 months, and there have been 19 patients who have not yet required therapy for periods of 3 to 104 months. The median actuarial survival for all 44 patients was 121 months. At 4 years, the actuarial survival of the 44 patients with deferred treatment is 77.3%, compared with 83.2% for the 112 protocol patients (P = 0.60). Careful observation without initiation of therapy is an appropriate option in the management of patients with relatively asymptomatic advanced non-Hodgkin's lymphomas of favorable histologic types.
Psychosocial Outcomes of Telemedicine Case Management for Elderly Patients With Diabetes
Authors: Paula M. Trief, Jeanne A. Teresi, Roberto Izquierdo, Philip C. Morin, Robin Goland, Leslie Field, Joseph P. Eimicke, Rebecca Brittain, Justin Starren, Steven Shea, Ruth S. Weinstock
Journal: Diabetes Care (2007)

Diabetes case management (DCM) may improve medical outcomes (1,2). Case managers coordinate care and often provide a mix of interventions, e.g., telephone outreach, education, reminders. However, the efficacy of DCM is unclear. Three systematic reviews lend only limited support for the efficacy of DCM for improving glycemic control but none for lipid, weight, or blood pressure benefits (3–5).

DCM studies typically target biomedical outcomes and ignore potential psychosocial effects. Yet, psychosocial variables (e.g., depression, anxiety, social support) relate to hyperglycemia, complications, adherence, and quality of life (6–11). Thus, a positive impact of DCM on these factors is important. Two studies did assess psychosocial outcomes of DCM and found improved self-efficacy and satisfaction (cluster visit) (12) and quality of life (dietitian-led DCM group) (13).

Because barriers (e.g., distance, weather) limit DCM access, telemedicine can be used. A review of telemedicine versus face-to-face trials concluded that, while feasible and acceptable, there is little evidence that telemedicine has clinical benefits (14). Our team published results of a trial of telemedicine DCM versus usual care for elderly diabetic patients (15). The intervention resulted in significant improvements in glycemic control, blood pressure, and total and LDL cholesterol (16).

The purpose of the Informatics for Diabetes Education and Telemedicine (IDEATel) project, funded by the Centers for Medicare and Medicaid Services, is to evaluate the feasibility and effectiveness of telemedicine with a diverse, medically underserved, elderly diabetic sample. The purpose of this study is to assess the impact of the IDEATel intervention on secondary psychosocial outcomes.

A detailed description of the IDEATel study design has been previously reported (15,16). Medicare recipients were recruited if they were aged ≥55 years, diagnosed with diabetes, and without moderate/severe impairments or comorbidities. Research nurses blinded to the groups …
Testing for the Human Immunodeficiency Virus (HIV) by Insurance Carriers
Authors: MICHAEL W. FULKS
Journal: Annals of Internal Medicine (1988)

Letters and Corrections1 June 1988Testing for the Human Immunodeficiency Virus (HIV) by Insurance CarriersMICHAEL W. FULKS, M.D.MICHAEL W. FULKS, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-108-6-907_1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: The position paper (1) on the acquired immunodeficiency syndrome (AIDS) and the human immunodeficiency virus (HIV) included the following statement on testing by insurance carriers that requires clarification.Insurance carriers may have legitimate interests in the HIV-antibody status of persons applying for life insurance, particularly in high-risk geographic areas of the country, and if they are single men between the ages 20 and 40, for example, and are seeking insurance in large sums.The insurance industry is closely regulated by the various states and is generally not permitted to do additional or special testing based on demographics....Reference1. . The acquired immunodeficiency syndrome (AIDS) and infection with the human immunodeficiency virus (HIV). Ann Intern Med. 1988;108:460-9. LinkGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: MICHAEL W. FULKS, M.D.Affiliations: State Mutual Companies Worcester, MA 01605 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 June 1988Volume 108, Issue 6Page: 907-907KeywordsAIDSGeographic areasHIV ePublished: 1 December 2008 Issue Published: 1 June 1988 PDF downloadLoading ...
Blood Supply of Long Bones
Authors: M. Brookes
Journal: BMJ (1963)

leukaemia a similar bi-modal seasonal distribution was observed.'The existence of two peaks was noted whether the time of clinical onset was studied, or the moment of diagnosis, or that of death.The same two peaks, one in winter and another in spring, were present when the total morbidity-i.e., the number of cases under observation at any given time- was plotted.During the discussion of our paper at the Lisbon Haematological Congress' two Continental haematologists stated that their findings were of a similar character.The bi-modal seasonal variation of certain types of leukaemia may be fruitfully compared with that of other neo- plastic diseases and diseases of viral aetio- logy.-Iam, etc.,
Neurotoxicity and Tretinoin
Authors: Lisa L. von Moltke
Journal: Annals of Internal Medicine (1996)

Letters15 November 1996Neurotoxicity and TretinoinLisa L. von Moltke, MD and David J. Greenblatt, MDLisa L. von Moltke, MDTufts University, Boston, MA 02111.Search for more papers by this author and David J. Greenblatt, MDTufts University, Boston, MA 02111.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-125-10-199611150-00023 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:We read with interest the case report linking neurotoxicity to the use of large amounts of topical tretinoin [1]. We wonder, however, whether some portion of the described clinical picture might be attributable to a confounding medication that has central nervous system activity, such as cyclobenzaprine. Although the most commonly reported adverse effects include dizziness, dry mouth, and drowsiness, ataxia and dysarthria have also been reported [2]. Obtaining plasma levels for other co-ingested medications may be a reasonable step in discovering the cause of the presenting problems of an unreliable patient who has access to unprescribed medication. ...References1. Bernstein AL, Leventhal-Rochon JL. Neurotoxicity related to the use of topical tretinoin (Retin-A). Ann Intern Med. 1996; 124:227-8. Google Scholar2. Cyclobenzaprine hydrochloride. Package insert. Danbury, CT: Danbury Pharmacal; 1992. Google Scholar Author, Article, and Disclosure InformationAffiliations: Tufts University, Boston, MA 02111. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByUse of topical tretinoin and the development of noncutaneous adverse events: Evidence from a systematic review of the literature 15 November 1996Volume 125, Issue 10Page: 861KeywordsAtaxiaBlood plasmaCentral nervous systemDrugsHalf lifeIngestionMetabolic disordersMouthPharmacokinetics Issue Published: 15 November 1996 CopyrightCopyright © 1996 by American College of Physicians. All Rights Reserved.PDF DownloadLoading ...
Doctors and managers: a problem without a solution?
Authors: N. Edwards
Journal: BMJ (2003)

In preparing this theme issue on doctors and managers we were offered many sophisticated descriptions of the origin and nature of the tension between doctors and managers but fewer credible solutions. The fundamental problem is a paradox between calls for a common set of values and the need to recognise that doctors and managers do and should think differently. If managers suddenly became preoccupied with the needs of an individual patient, irrespective of the consequences for others or for their budget, then the health system would collapse. If doctors decided that their principal concern was to ensure the smooth running of the system and the delivery of policy irrespective of the consequences for the patient in front of them, then both the quality of care and public support would collapse. Doctors worry about patient outcomes. Managers worry about patient experience (which includes outcomes, but only as part of a mix to be met out of finite resources). Patients are, again, best served by a tension between the two.

Admitting that this paradox …
Plasma levels of lipoproteins and apolipoproteins in congenital hypothyroidism: Effects of l-thyroxine substitution therapy
Authors: Carlo M. Barbagallo, Maurizio R. Averna, Andrea Liotta, Stefania La Grutta, Cristina Maggio, Lucia Casimiro, Angelo B. Cefalù, Alberto Notarbartolo
Journal: Metabolism (1995)
Hospital Nurse Recruitment and Retention: A Source Book for Executive Management
Authors: Phil Gunby
Journal: JAMA (1981)

Noting that between 30% and 40% of the 1.4 million qualified nonretired registered nurses in the United States are, by their own choice, not working in nursing, and that "the number of new nurse graduates available to fill the jobs is declining at an ever increasing rate," the American Hospital Association says a multidisciplinary comprehensive approach is needed to find long-range solutions. The AHA, which is in the midst of a national public service campaign to help hospitals overcome this problem, suggests among other things that "activities or programs that enhance the physician's perception of the nurse as a professional colleague should be an ongoing responsibility of the hospital medical staff." The<i>Source Book</i>consists of four modules. The first, addressing nurse retention, notes, "Nurses have long complained that physicians have not recognized the value of the nurse's participation in patient care," and offers examples of how hospitals might develop
Effects of barium-induced cardiac contraction on large- and small-vessel intramyocardial blood volume.
Authors: R M Judd, B I Levy
Journal: Circulation Research (1991)

We have measured the effects of barium-induced cardiac contraction on the intramyocardial blood volume content of all vessels and have independently measured the blood volume content of vessels with a diameter greater than 100 microns in rat myocardium. Measurements of total intramyocardial blood volume were made by using [125I]albumin as a plasma marker and technetium-99m as a red blood cell marker. In one group of rats (n = 8), diastolic arrest was induced by an intravenous injection of KCl; in a second group (n = 8), systolic arrest was induced by an intravenous injection of BaCl2. In both groups, the hearts were frozen in situ immediately after heart arrest while aortic pressure was decaying from its former physiological level. The left ventricular free wall was sectioned transmurally in a cryomicrotome, and the blood volume within each tissue sample was calculated from its radioactivity. The volume of blood in vessels larger than 100 microns was independently estimated from the exposed cross-sectional area of these vessels in photographs of the frozen tissue taken during tissue sectioning in the cryomicrotome. Total intramyocardial blood volume was found to decrease by about 42% from 8.6 +/- 1.3 ml/100 g (mean +/- SEM) in the KCl group to 5.0 +/- 0.7 ml/100 g in the BaCl2 group (p less than 0.01). Total volume was greater in the epicardial than in the endocardial layers of both groups (p less than 0.05).(ABSTRACT TRUNCATED AT 250 WORDS)
Leaking rheumatoid olecranon bursitis as a cause of forearm swelling.
Authors: J D Macfarlane, S J van der Linden
Journal: Annals of the Rheumatic Diseases (1981)

AbstractA patient with seropositive rheumatoid arthritis and recurrent oedema of the forearm was shown to have a leak from a multilobulated olecranon bursa.
Survival to the Age of Seventy-Five Years with Congenital Pulmonary Stenosis and Patent Foramen Ovale
Authors: PAUL D. WHITE, JOHN W. HURST, ROBERT H. FENNELL
Journal: Circulation (1950)

It is very rare for a person with cyanosis and finger clubbing due to congenital heart disease to reach old age. Survival beyond the age of 50 has been noted only a few times and, as far as we are aware, survival of a person with morbus caeruleus beyond 70 years is unique. The patient reported below showed at autopsy marked pulmonary stenosis and patency of the atrial septum simulating the tetralogy of Fallot. One of the reasons for the long survival was undoubtedly a markedly developed collateral bronchial circulation.
Virus-Tumor Interactome Screen Reveals ER Stress Response Can Reprogram Resistant Cancers for Oncolytic Virus-Triggered Caspase-2 Cell Death
Authors: Douglas J. Mahoney, Charles Lefebvre, Kristina Allan, Jan Brun, Cina A. Sanaei, Stephen Baird, Nelson Pearce, Susanna Grönberg, Brian Wilson, Mikael Prakesh, Ahmed Aman, Methvin Isaac, Ahmed Mamai, David Uehling, Rima Al-Awar, Theresa Falls, Tommy Alain, David F. Stojdl
Journal: Cancer Cell (2011)
Modification of Alcohol Withdrawal by the A<sub>9</sub>Allele of the Dopamine Transporter Gene
Authors: Lutz G. Schmidt, Helmut Harms, Silke Kuhn, Hans Rommelspacher, Thomas Sander
Journal: American Journal of Psychiatry (1998)

OBJECTIVE: Determinants of individual vulnerability to alcohol withdrawal symptoms are largely unknown. Because of the substantial role of monoaminergic transporters in limiting time and space effects of synaptic neurotransmission, the dopamine transporter gene (DAT1; locus symbol: SLC6A3) was studied as a candidate gene possibly related to symptoms of uncomplicated alcohol withdrawal. METHOD: In 48 chronically intoxicated alcoholics (diagnosed according to ICD-10), withdrawal symptoms were examined and the presence of a variable-number tandem repeat in the 3′ untranslated region of the DAT1 gene was determined. RESULTS: Withdrawal syndromes were more pronounced in the 22 patients carrying the nine-copy repeat than in the 26 patients without this variant. Multiple regression analysis revealed that 4% of the variance of withdrawal was explained by this genotype, whereas 16% was due to the amount of alcohol the patients reported having consumed in the month before detoxification. CONCLUSIONS: The A9 allele of the dopamine transporter gene is associated with more severe effects of alcohol withdrawal, possibly because of modifications of the brain's capacity to compensate for long-term effects of ethanol on cerebral function.
Control of HCV replication: When size does not matter
Authors: Michael R. Beard, Karla J. Helbig
Journal: Hepatology (2008)

RNA interference through non-coding microRNAs (miRNAs) represents a vital component of the innate antiviral immune response in plants and invertebrate animals; however, a role for cellular miRNAs in the defence against viral infection in mammalian organisms has thus far remained elusive. Here we show that interferon beta (IFNbeta) rapidly modulates the expression of numerous cellular miRNAs, and that eight of these IFNbeta-induced miRNAs have sequence-predicted targets within the hepatitis C virus (HCV) genomic RNA. The introduction of synthetic miRNA-mimics corresponding to these IFNbeta-induced miRNAs reproduces the antiviral effects of IFNbeta on HCV replication and infection, whereas neutralization of these antiviral miRNAs with anti-miRNAs reduces the antiviral effects of IFNbeta against HCV. In addition, we demonstrate that IFNbeta treatment leads to a significant reduction in the expression of the liver-specific miR-122, an miRNA that has been previously shown to be essential for HCV replication. Therefore, our findings strongly support the notion that mammalian organisms too, through the interferon system, use cellular miRNAs to combat viral infections.