MASSIVE DOSES OF CORTISONE IN HEPATIC COMA
Authors: T PESSAR, J W HESSING
Journal: Annals of Internal Medicine (1958)

Article1 June 1958MASSIVE DOSES OF CORTISONE IN HEPATIC COMATHEODORE PESSAR, M.D., F.A.C.P., JOHN W. HESSING, M.D.THEODORE PESSAR, M.D., F.A.C.P.Search for more papers by this author, JOHN W. HESSING, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-48-6-1253 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptHepatic coma is a frequent terminal occurrence in advanced atrophic or postnecrotic cirrhosis. Coma can be precipitated in patients with pre-existing liver damage by hepatotoxic agents, infection, physical overactivity, improper use of sedatives or narcotics, inadequate diet, trauma or surgery.Hepatic coma carries with it a high mortality. Murphy1in his series of 42 cases had 40 deaths. Snell,2in a series of cases reported from the Mayo Clinic, showed that 23 out of 54 cases of atrophic cirrhosis died in coma. Karl et al.,3in a review of 58 cases of hepatic coma selected from the records of the...Bibliography1. MurphyChalmersEckhardtDavidson TLTCRDCS: Hepatic coma, clinical and laboratory observations, New England J. Med. 239: 605, 1948. CrossrefMedlineGoogle Scholar2. SnellButt AMHR: Hepatic coma, observations bearing on its nature and treatment, Tr. A. Am. Physicians 56: 321, 1941. Google Scholar3. KarlHowellHutchinsonCatanzaro MRAJHFJ: Liver coma with particular reference to management, Arch. Int. Med. 91: 159, 1953. CrossrefGoogle Scholar4. PostRoseShore JJVSM: Intravenous use of salt free human albumen, effects in 34 patients with decompensated cirrhosis, Arch. Int. Med. 87: 775, 1951. CrossrefGoogle Scholar5. Snell AM: Panel on liver diseases, J. A. M. A. 158: 116, 1955. MedlineGoogle Scholar6. SklarYoung MII: Failure of ACTH and adrenal corticoids to alter the course of hepatic coma in advanced portal cirrhosis, Am. J. M. Sc. 229: 138, 1955. CrossrefMedlineGoogle Scholar7. Eisenmenger WJ: Hepatic cirrhosis of liver—panel discussion on therapeutics, Bull. New York Acad. Med. 30: 43, 1954. MedlineGoogle Scholar8. DucciKatz HR: Cortisone, ACTH in fulminating hepatitis, Gastroenterology 21: 357, 1952. CrossrefMedlineGoogle Scholar9. Zoeckler SJ: Cortisone in portal cirrhosis, Gastroenterology 26: 878, 1954. CrossrefMedlineGoogle Scholar10. HuberWeltz TEAI: Cortisone in the treatment of infectious hepatitis, Ann. Int. Med. 42: 1011, 1955. LinkGoogle Scholar11. Butt HR: Hepatic coma, its current status, Arch. Int. Med. 94: 321, 1954. CrossrefGoogle Scholar12. Schwartz K: Inhibitory effect of cortisone on dietary necrotic liver degeneration in the rat, Science 113: 485, 1951. CrossrefMedlineGoogle Scholar13. VorhausVorhaus EJLJ: Protective effects of pre-treatment with cortisone, Aureomycin, and folic acid in carbon tetrachloride induced hepatic injury in rats, Gastroenterology 26: 887, 1954. CrossrefMedlineGoogle Scholar14. FlinkWilliams EBCF: Effect of corticotropin administration on blood bile acids and pruritus in biliary cirrhosis, J. Clin. Investigation 31: 627, 1952. Google Scholar15. Roberts S: The influence of the adrenal cortex on the mobilization of tissue protein, J. Biol. Chem. 200: 77, 1953. CrossrefMedlineGoogle Scholar16. BongiovanniEisenmenger AMWJ: Observations during the administration of ACTH to patients with chronic liver disease, Proceedings of the Second Clinical ACTH Conference, Vol. 1, page 390, 1951, The Blakiston Co., Philadelphia. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: *Received for publication June 15, 1956.From the Medical Service, Queens General Hospital, Jamaica, Queens, N. Y.Requests for reprints should be addressed to Theodore Pessar, M.D., 37-31 149th Street, Flushing, Long Island, N. Y. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 June 1958Volume 48, Issue 6Page: 1253-1268KeywordsAnemiaCirrhosisComaDietHemorrhageLiverMedical servicesMortalitySedativesTrauma surgery ePublished: 1 December 2008 Issue Published: 1 June 1958 PDF downloadLoading ...