tbuckley/cabot-search huggingface dataset:
CHANGES IN LEFT VENTRICULAR FUNCTION AND VOLUMES DETERMINED BY CARDIAC MAGNETIC RESONANCE IMAGING AFTER SUCCESSFUL RECANALIZATION OF TRUE CHRONIC TOTAL OCCLUSION IN NATIVE CORONARY ARTERIES
Authors: Jochen Woehrle, Philipp Chadid, Manuela Mariyadas, Sinisa Markovic, Wolfgang Rottbauer, Peter Bernhardt
Journal: Journal of the American College of Cardiology (2012)
Identification of Clinical Features and Autoantibodies Associated With Calcinosis in Dermatomyositis
Authors: Antonia Valenzuela, Lorinda Chung, Livia Casciola-Rosen, David Fiorentino
Journal: JAMA Dermatology (2014)

Prior studies have estimated that up to 20% of adults with dermatomyositis (DM) have calcinosis, which can lead to significant morbidity. Identification of risk factors may provide a better understanding of the pathogenesis and ultimately therapy for this difficult clinical problem. Risk factors for calcinosis in adults with DM have not been extensively studied.To determine the prevalence of calcinosis and to identify associated clinical features in a cohort of extensively phenotyped adults with DM.A cross-sectional study of 126 patients diagnosed as having DM from January 1, 2006, through January 1, 2013, was performed. Patients were adults (≥18 years of age) attending the Stanford University Medical Center clinic.Calcinosis, defined as the presence of calcium deposition in the skin and subcutaneous tissues on physical examination.Fourteen patients (11.1%) had calcinosis, with the extremities most commonly involved. Patients with vs those without calcinosis had a longer disease duration (median, 6.9 years; range, 2.4-18.1; vs median, 3.9 years; range, 0.2-19.2 years; P = .003) and more fingertip ulcers (50.0% vs 9.3%, P < .001). An association between calcinosis and both interstitial lung disease and anti-MDA-5 autoantibodies was identified, but this association did not persist in multivariate models that adjusted for fingertip ulcers. Fingertip ulcers and disease duration were strongly associated with calcinosis in all multivariate models, independent of the underlying autoantibody present. Autoantibodies to NXP-2 were associated with calcinosis (odds ratio, 15.52; 95% CI, 2.01-119.90), whereas anti-transcriptional intermediary factor 1-γ antibodies were protective (odds ratio, 0.2; 95% CI, 0.01-0.99) in multivariate analyses that adjusted for fingertip ulcers and other covariates.Calcinosis was a relatively uncommon clinical feature in our cohort of adults with DM. Our data suggest that calcinosis is positively associated with longer disease duration, fingertip ulcers, and NXP-2 autoantibodies and negatively associated with transcriptional intermediary factor 1-γ antibodies. A common vascular mechanism may underlie the development of both calcinosis and fingertip ulcers in patients with DM.
ACCUMULATION OF ANTIBODIES IN THE CENTRAL NERVOUS SYSTEM
Authors: Jules Freund
Journal: The Journal of Experimental Medicine (1930)

1. Antibodies can be extracted from the brain and spinal cord of rabbits actively or passively immunized with typhoid bacilli. 2. The titers of the antibodies in the extracts of brain and cord depend upon the titer of the blood serum. In actively immunized rabbits the following numerical relationships exist between the titers of the serum and of these organ extracts: The ratio of the titer of the serum is to the titers of extract of brain and of the spinal cord about as 100 is to 0.8; the titer of the serum is to the titer of the cerebrospinal fluid as 100 is to 0.3. In passively immunized rabbits the titer of the serum is to the titer of brain and spinal-cord extract as 100 is to 0.7. 3. The antibodies recovered from the brain are not due to the presence of blood in it for perfusion of the brain does not reduce its antibody content appreciably. 4. Antibodies penetrate into the spinal fluid from the blood even in the absence of inflammation of the meninges. When the penetration is completed the following numerical relationship exists between the titer of the serum and that of the cerebrospinal fluid: 100 to 0.25. 5. The penetration into the cerebrospinal fluid of antibodies injected intravenously proceeds at a slow rate, being completed only several hours after the immune serum has been injected. The penetration of antibodies into the tissue of the brain occurs at a very rapid rate. It is completed within 15 minutes. 6. It is very unlikely that when the immune serum is injected intravenously the antibodies reach the brain tissue by way of the cerebrospinal fluid, for (1) the antibody titer of the cerebrospinal fluid is lower than that of the brain extract, and (2) antibodies penetrate faster into the tissue of the brain than into the cerebrospinal fluid.
The Emerging Epidemic of Atherosclerosis
Authors: Margaret A. Winker
Journal: JAMA (1999)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
RG7204 (PLX4032), a Selective BRAFV600E Inhibitor, Displays Potent Antitumor Activity in Preclinical Melanoma Models
Authors: Hong Yang, Brian Higgins, Kenneth Kolinsky, Kathryn Packman, Zenaida Go, Raman Iyer, Stanley Kolis, Sylvia Zhao, Richard Lee, Joseph F. Grippo, Kathleen Schostack, Mary Ellen Simcox, David Heimbrook, Gideon Bollag, Fei Su
Journal: Cancer Research (2010)

The BRAF(V600E) mutation is common in several human cancers, especially melanoma. RG7204 (PLX4032) is a small-molecule inhibitor of BRAF(V600E) kinase activity that is in phase II and phase III clinical testing. Here, we report a preclinical characterization of the antitumor activity of RG7204 using established in vitro and in vivo models of malignant melanoma. RG7204 potently inhibited proliferation and mitogen-activated protein/extracellular signal-regulated kinase (ERK) kinase and ERK phosphorylation in a panel of tumor cell lines, including melanoma cell lines expressing BRAF(V600E) or other mutant BRAF proteins altered at codon 600. In contrast, RG7204 lacked activity in cell lines that express wild-type BRAF or non-V600 mutations. In several tumor xenograft models of BRAF(V600E)-expressing melanoma, we found that RG7204 treatment caused partial or complete tumor regressions and improved animal survival, in a dose-dependent manner. There was no toxicity observed in any dose group in any of the in vivo models tested. Our findings offer evidence of the potent antitumor activity of RG7204 against melanomas harboring the mutant BRAF(V600E) gene.
Hyperglycemia Promotes Myelopoiesis and Impairs the Resolution of Atherosclerosis
Authors: Prabhakara R. Nagareddy, Andrew J. Murphy, Roslynn A. Stirzaker, Yunying Hu, Shiquing Yu, Rachel G. Miller, Bhama Ramkhelawon, Emilie Distel, Marit Westerterp, Li-Shin Huang, Ann Marie Schmidt, Trevor J. Orchard, Edward A. Fisher, Alan R. Tall, Ira J. Goldberg
Journal: Cell Metabolism (2013)
Caring for the Dying in the Intensive Care Unit
Authors: Graeme M. Rocker, J. Randall Curtis
Journal: JAMA (2003)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Inhibition of Angiogenesis In Vivo by Interleukin 12
Authors: E. E. Voest, B. M. Kenyon, M. S. O'Reilly, G. Truitt, R. J. D'Amato, J. Folkman
Journal: JNCI Journal of the National Cancer Institute (1995)

Journal Article Inhibition of Angiogenesis In Vivo by Interleukin 12 Get access Emile E. Voest, Emile E. Voest *Departments of Surgery and Cell Biology, Harvard Medical SchoolBoston, Mass Search for other works by this author on: Oxford Academic PubMed Google Scholar Bärbel M. Kenyon, Bärbel M. Kenyon *Departments of Surgery and Cell Biology, Harvard Medical SchoolBoston, Mass Search for other works by this author on: Oxford Academic PubMed Google Scholar Michael S. O'Reilly, Michael S. O'Reilly *Departments of Surgery and Cell Biology, Harvard Medical SchoolBoston, Mass Search for other works by this author on: Oxford Academic PubMed Google Scholar Gary Truitt, Gary Truitt Department of Oncology, Hoffmann-La Roche Inc.Nutley, NJ Search for other works by this author on: Oxford Academic PubMed Google Scholar Robert J. D'Amato, Robert J. D'Amato *Departments of Surgery and Cell Biology, Harvard Medical SchoolBoston, Mass Search for other works by this author on: Oxford Academic PubMed Google Scholar Judah Folkman Judah Folkman *Departments of Surgery and Cell Biology, Harvard Medical SchoolBoston, Mass Judah Folkman, M.D., Children's Hospital, Hunnewell 103, 300 Longwood Ave., Boston, MA 02115. Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 87, Issue 8, 19 April 1995, Pages 581–586, https://doi.org/10.1093/jnci/87.8.581 Published: 19 April 1995
Skin Sensitivities to "Allergens"
Authors: J. J. Robbins
Journal: JAMA (1966)

To the Editor:—  Howard J. Schwartz, MD, demonstrated that injection of whole-body extracts of various insects produced skin reactions irrespective of how the subjects reacted to stings of these insects ( 194 :703, 1965).  A similar study by Fontana et al ( J Allerg  34 :348, 1963) showed that reactions to injections of dust were not related to respiratory allergy. After all, it is not really surprising that an injection of such foreign proteins (no less than heterogeneous blood or dirt euphemistically called dust) is likely to produce reactions when parenterally injected in patients even without allergic diathesis.  In view of his findings on skin testing I fail to understand the reasoning which leads to the opinion that skin testing is of value as a guide to starting doses in hyposensitization therapy. Since the advocates of desensitization to insect stings say that it requires two to three years of treatment to obtain
Correction: “Key to the Future”: British American Tobacco and Cigarette Smuggling in China
Authors: Kelley Lee, Jeff Collin
Journal: PLoS Medicine (2006)

In PLoS Medicine, volume 3, issue 7: DOI: 10.1371/journal.pmed.0030228

In Table 1, column 3, last row, the value 113,919 is incorrect; it should be 117,964.
Influenza Vaccine — Outmaneuvering Antigenic Shift and Drift
Authors: John Treanor
Journal: New England Journal of Medicine (2004)

The winter of 2003–2004 will be remembered as a year in which stories about influenza dominated the news and patients young and old clamored for influenza vaccination. This intense interest is the result of the confluence of multiple circumstances. The onset of the annual influenza epidemic came earlier than expected and was accompanied by reports of severe disease in previously healthy children, associated with the isolation of antigenically variant influenzaviruses represented by the prototypic strain A/Fujian/411/2002 (H3N2). There was concern that the available influenza vaccine would not be optimally effective against this strain of virus, but at the same time, . . .
Children of HIV infected mothers have heart damage, says report
Authors: D. Josefson
Journal: BMJ (2002)

Infants born to mothers infected with HIV sustain cardiac damage regardless of whether they contract the viral infection, a new study has found. However, although the defects tend to normalise in uninfected children, clinical follow up is still warranted, the authors conclude.

The researchers assessed heart structure and function by echocardiography in 600 newborns of HIV infected mothers and monitored the children every four to six months for up to five years. Ninety three infants had HIV and 463 infants were born uninfected. A control cohort of 195 healthy infants born to uninfected mothers was used for comparison.

Overall, …
Response to correspondence on the molecular biology of head and neck cancer
Authors: C. René Leemans, Boudewijn J. M. Braakhuis, Ruud H. Brakenhoff
Journal: Nature reviews. Cancer (2011)

Tumour-microenvironment interaction is an interesting new field in cancer research.However, it is not specific to head and neck cancer and is still in its infancy.Therefore, it was not the focus of our Review on the molecular biology of head and neck cancer (The molecular biology of head and neck cancer.Nature Rev. Cancer 11, 9-22 (2011)) 1 .We refrained from listing the different sub-sites within the head and neck sites.Vered et al.(The role of the tumour microenvironment in the biology of head and neck cancer: lessons from mobile tongue cancer.Nature Rev. Cancer 31 Mar 2011 (doi:10
Cohort study of peanut and tree nut sensitisation by age of 4 years
Authors: S M Tariq, M Stevens, S Matthews, S Ridout, R Twiselton, D W Hide
Journal: BMJ (1996)

<h3>Abstract</h3> <b>Objective</b>: To determine the prevalence of sensitisation to peanuts and tree nuts in all children born during one year in one geographical area. <b>Design</b>: Birth cohort study with structured review at ages 1, 2, and 4 years. <b>Setting</b>: All children born on the Isle of Wight between January 1989 and February 1990. <b>Subjects</b>: Of 1456 children originally included, 1218 were reviewed at age 4 years. Of these, 981 had skin prick tests. <b>Main outcome measures</b>: Positive skin test results, clinical atopic disease, and risk factors for the development of atopy. <b>Results</b>: 15 of 1218 (1.2%) children were sensitised to peanuts or tree nuts (13 to peanuts). Six had had allergic reactions to peanuts (0.5% of the population), one to hazelnuts, and one to cashew nuts; three had had anaphylactic reactions. Seven children had positive skin test results or detectable IgE to peanuts without clinical symptoms. Two children who reacted to peanut in infancy had lost their sensitivity by 4 years. Family history of atopy, allergy to egg (odds ratio 9.9, 95% confidence interval 2.1 to 47.9, and eczema (7.3, 2.1 to 26.1) were important predictors for peanut allergy. <b>Conclusions</b>: IgE mediated allergy to peanuts is common in early childhood. In many the allergy persists but a minority may develop tolerance. <h3>Key messages</h3> Key messages This study suggests that 1 in 200 children could have reactions to peanuts and tree nuts by the age of 4 years and a similar number could have asymp- tomatic sensitisation Children with allergy to peanuts invariably have another atopic disorder such as asthma, eczema, or rhinitis Sensitisation to peanuts and tree nuts may coexist
Effect Of Tnf-α (-308g/a) Polymorphism And Combined Effect With Il-13 Polymorphisms In Bronchial Responsiveness Of Korean Children With Asthma
Authors: H. Kim, M. Kang, S. Lee, J. Kim, B. Kim, S. Jang, M. Sohn, K. Kim, S. Hong
Journal: Journal of Allergy and Clinical Immunology (2007)
Toxic shock syndrome after minor surgery.
Authors: R M McAllister
Journal: BMJ (1993)

tuberculosis in health care workers in central France.I studied cases of tuberculosis in hospital em- ployees between 1984 and 1992.Sixty two cases of occupationally acquired tuberculosis occurred during this period.In all cases the employees had had BCG vaccination, but in 41 cases the tuberculosis occurred more than 15 years after the vaccination.The World Health Organisation and many authors consider that BCG vaccination gives about 80% protection, but only for 15 years.2Thus in these 41 cases the protection offered by BCG vaccination may have disappeared.Health care workers should have a tuberculin skin test at least every two years.A further BCG injection should be given if the result of the test is negative.In 44 cases in this study tuberculosis was detected by a routine chest x ray examination.Chest x ray screening, though more costly, is more effective than skin testing.As the number of patients admitted to hospital with HIV infection and tuberculosis increases, the risk of nosocomial transmission to staff may rise, and new thought must be given to prevention.
Thrombosis and Atherosclerosis
Authors: Peter T. Kuo
Journal: JAMA (1982)

For a long time, much emphasis has been placed on the epidemiologically identified risk factors in the development of atherosclerosis and its devastating complications. Recent advances in our understanding of the basic mechanisms of vascular thrombosis and of its clinical applications have rekindled the interest of investigators from a diversity of scientific disciplines in the association between venous and arterial thrombosis and development of vascular diseases in general and atherosclerosis in particular. The editors have invited outstanding basic science and clinical investigators to collaborate with them to contribute information on thromboembolism from diverse but interrelated fields. A total of 35 contributors combined their experiences and efforts to write 32 chapters for the book. Part 1 of the book is devoted to pathophysiology and diagnosis of venous thrombosis. Part 2 is on venous thromboembolism, prevention and treatment. Discussions presented in part 3 have direct bearing on atherosclerosis. A portion of this
Transient hypertension caused by segmental renal artery occlusion.
Authors: H B Benraad, T J Benraad, P W Kloppenborg
Journal: BMJ (1969)

MEDIBALJOURNAL cosactrin (see Table ).During this period there was no signi- ficant difference between the response to doses of 0 25 and 15 mg.The high dose, however, gave significantly higher responses at 90, 120, and 180 minutes (P<0 01).The peak of the response was seen at 60 minutes and persisted to 90 minutes with the higher dose.At five hours after zero time the plasma fluorogenic corticosteroids were still significantly higher than the baseline specimens after both 0 25 and 1-5 mg.(P<0 05 and P<0 01 respectively).Levels of Plasma Fluorogenic Corticosteroids After Nasal Insufflation of Tetracosactrin (Results Expressed in u..g./100 ml. of Plasma) Dose of Tetracosactrin Time 0 25 mg. 15mg.Mean S. E. Mean S.E.Baseline .1 5 0 5 2.0 0 4 15 min.15 9 2 8 17 3 1 5 30 ,,
Gli Activity Correlates with Tumor Grade in Platelet-Derived Growth Factor–Induced Gliomas
Authors: Oren J. Becher, Dolores Hambardzumyan, Elena I. Fomchenko, Hiroyuki Momota, Lori Mainwaring, Anne-Marie Bleau, Amanda M. Katz, Mark Edgar, Anna M. Kenney, Carlos Cordon-Cardo, Ron G. Blasberg, Eric C. Holland
Journal: Cancer Research (2008)

Abstract Gli signaling is critical for central nervous system development and is implicated in tumorigenesis. To monitor Gli signaling in gliomas in vivo, we created platelet-derived growth factor–induced gliomas in a Gli-luciferase reporter mouse. We find that Gli activation is found in gliomas and correlates with grade. In addition, we find that sonic hedgehog (SHH) is expressed in these tumors and also correlates with grade. We identify microvascular proliferation and pseudopalisades, elements that define high-grade gliomas as SHH-producing microenvironments. We describe two populations of SHH-producing stromal cells that reside in perivascular niche (PVN), namely low-cycling astrocytes and endothelial cells. Using the Ptc-LacZ knock-in mouse as a second Gli responsive reporter, we show β-galactosidase activity in the PVN and in some tumors diffusely throughout the tumor. Lastly, we observe that SHH is similarly expressed in human gliomas and note that an intact tumor microenvironment or neurosphere conditions in vitro are required for Gli activity. [Cancer Res 2008;68(7):2241–49]
Genetic Determinants of Mitochondrial Response to Arsenic in Yeast<i>Saccharomyces cerevisiae</i>
Authors: Marija Vujcic, Meghna Shroff, Keshav K. Singh
Journal: Cancer Research (2007)

Abstract We have used yeast Saccharomyces cerevisiae as a tool to identify the importance of mitochondrial processes involved in arsenic-induced carcinogenicity in humans. We screened 466 single-gene knockout strains of yeast S. cerevisiae known to be involved in biogenesis of mitochondria for sodium arsenite (AsIII) and sodium arsenate (AsV) sensitivity. We identified 72 arsenite-sensitive and 81 arsenate-sensitive mutants. We categorized the identified mutants based on the various mitochondrial processes, including nucleic acid metabolism, oxidative phosphorylation, protein synthesis, and vacuolar acidification. We have identified 65 human orthologues to proteins involved in arsenite sensitivity and 3 human orthologues to arsenite resistance. Furthermore, 23 human orthologues to arsenate sensitivity and 20 human orthologues to arsenate-resistant proteins, including MSH3, COX10, GCSH, PPOX, and MTHFD1, were also identified. Using PathwayAssist software, we did cellular network analysis between identified mitochondrial proteins. Three types of interactions, (a) protein-protein interactions, (b) common transcriptional regulators, and (c) common target genes, were identified. We found that RTG (retrograde) genes involved in mitochondria-to-nucleus signaling regulate both arsenite sensitivity and resistance. Furthermore, our study revealed that ABF1, a multifunctional transcriptional factor, regulates genes involved in both arsenite and arsenate sensitivity and resistance. However, REB1 and RAP1 transcriptional regulators were common to only arsenate- and arsenite-sensitive genes, respectively. These studies indicate that multiple pathways involved in mitochondrial biogenesis protect yeast S. cerevisiae from arsenic-induced toxicity. Together, our studies suggest that evolutionary conserved mitochondrial networks identified in yeast S. cerevisiae must play an important role in arsenic-induced carcinogenesis in humans. [Cancer Res 2007;67(20):9740–9]
Metastatic Occlusion of a Lymphatic Collecting Vessel in a Patient With Cutaneous Melanoma and Clinically Normal Lymph Nodes
Authors: Roger F. Uren, Robert Howman-Giles, David K. V. Chung, John F. Thompson
Journal: Clinical Nuclear Medicine (2007)

This case illustrates a blocked lymphatic collecting vessel on lymphoscintigraphy which was passing toward the right groin in the absence of any palpable abnormality in the right groin. No sentinel node was therefore seen in the right groin but sentinel nodes were seen in the left groin and left axilla. High resolution ultrasound was normal except for the right groin where a subcapsular lymph node metastasis was suspected. Fine needle biopsy under ultrasound control revealed melanoma metastasis.