NEW DRUG THERAPIES IN ARTERIAL HYPERTENSION
Authors: R W WILKINS
Journal: Annals of Internal Medicine (1952)

Article1 December 1952NEW DRUG THERAPIES IN ARTERIAL HYPERTENSIONROBERT W. WILKINS, M.D., F.A.C.P.ROBERT W. WILKINS, M.D., F.A.C.P.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-37-6-1144 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptINTRODUCTIONDrugs and procedures for the treatment of essential hypertension of necessity must be nonspecific in nature, since the etiology of this disease is unknown. Undoubtedly, this fact accounts for the diverse nature of the methods that have been advocated for lowering the blood pressure and likewise for the similarity of the clinical results reported to be obtained by these various methods. Thus, surgical sympathectomy, or adrenalectomy, intravenous pyrogens, low sodium diets, the administration of adrenergic- or ganglionic-blocking agents, neural vaso dilators such as veratrum, peripheral vasodilators such as nitrites, and even drugs with unknown modes of action such as...Bibliography1. Report of the Royal Society of Medicine. Medical treatment of hypertension, Lancet 1: 492 (March 8) 1952. MedlineGoogle Scholar2. KilpatrickSmirk JAFH: Comparison of oral and subcutaneous administration of methonium salts in the treatment of high blood-pressure, Lancet 1: 8 (Jan. 5) 1952. CrossrefMedlineGoogle Scholar3. FreisFinnertySchnaperJohnson EDFAHWRL: The treatment of hypertension with hexamethonium, Circulation 5: 20, 1952. CrossrefMedlineGoogle Scholar4. Schroeder HA: Control of hypertension by hexamethonium and 1-hydrazinophthalazine, Arch. Int. Med. 89: 523, 1952. CrossrefGoogle Scholar5. 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WilkinsJudsonStanton RWWEJR: Preliminary observations on Rauwolfia serpentina in hypertensive patients, presented before the New England Cardiovascular Society on February 4, 1952. Proceedings of the New England Cardiovascular Society, 1951-1952, page 34. Google Scholar23. Kinsey D: Personal communication. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Boston, Massachusetts*From the Symposium on Arterial Hypertension presented at the Thirty-third Annual Session of the American College of Physicians, Cleveland, Ohio, April 23, 1952. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byThe VA Co-operative Studies; The First RCTs in Cardiovascular Disease – A Tribute to Edward D. FreisWhy Are the Majority of Active Compounds in the CNS Domain Natural Products? A Critical AnalysisGuidelines for the Management of HypertensionThe Hypertension Paradox — More Uncontrolled Disease despite Improved TherapyThe introduction of ganglion blocking drugs for the treatment of hypertension.Effects on the General Hemodynamics and Peripheral CirculationEffects of Prolonged Administration of Certain Antihypertensive AgentsMODERN CONCEPTS IN THE MANAGEMENT OF ANXIETY AND DEPRESSION IN THE AGED AND INFIRMRauwolfia Alkaloids and Serotonin Antagonists in HypertensionA Comparison of the Side Effects and Antihypertensive Potency of Chlorothiazide and HydrochlorothiazideHypertonieDEPRESSIONS IN PATIENTS TREATED WITH RESERPINE FOR ARTERIAL HYPERTENSIONTHERAPEUTICALLY "REFRACTORY" HYPERTENSION: CAUSATIVE FACTORS, AND MEDICAL MANAGEMENT WITH CHLOROTHIAZIDE AND OTHER AGENTS*RICHARD E. LEE, ARTHUR W. SELIGMANN, MELVA A. CLARK, NEMAT O. BORHANI, JOHN T. QUEENAN, MAUREEN E. O'BRIENFROM SNAKE ROOT TO SEROTONIN†New Drugs for Hypertension, with Special Reference to ChlorothiazideEffect of Rauwolfa serpentina and Reserpine on the Blood Pressure in Essential HypertensionSerotonin, Antiserotonins and HypertensionThe Management of Hypertensive Cardiovascular DiseaseDie Wirkung von Reserpin auf die Haut- und Muskeldurchblutung bei gesunden Menschen und HochdruckkrankenTREATMENT OF PRIMARY HYPERTENSION IN THE OLDER AGE GROUPThe Alkaloids of Rauwolfia Serpentina Benth*RAUWOLFIA SERPENTINA (SERPASIL) IN PSYCHIATRYClinical results with the use of Roxinil (an extract of Rauwolfia serpentina) in the treatment of hypertensionTHIRTY-THREE YEARS' EXPERIENCE IN THE MANAGEMENT OF ARTERIAL HYPERTENSION†Treatment of Hypertension with Reserpine,with Reserpine in Combination with Pentapyrrolidinium,and with Reserpine in Combination with Veratrum AlkaloidsCombined Rauwolfia-Hydralazine Therapy of Hypertensive PatientsThe value of Rauwolfia serpentina in the hypertensive patientRauvolfia serpentina—Its history, botany and medical useClinical Evaluation of Hydralazine (Apresoline) Alone and in Combination with Veriloid in the Treatment of HypertensionCONTROL OF BLOOD-PRESSURE BY COMBINED ACTION OF RESERPINE AND PENTAPYRROLIDINIUMLECTURE I: TREATMENT OF HYPERTENSIONCLINICAL USAGE OF RAUWOLFIA ALKALOIDS, INCLUDING RESERPINE (SERPASIL)USE OF RAUWOLFIA SERPENTINA BENTH. IN NEUROPSYCHIATRIC CONDITIONSReserpine in the Treatment of HypertensionTHE CLINICAL COURSE, FOLLOWING ADRENAL RESECTION AND SYMPATHECTOMY, OF 82 PATIENTS WITH SEVERE HYPERTENSION*WILLIAM A. JEFFERS, F.A.C.P., HAROLD A. ZINTEL, JOSEPH H. HAFKENSCHIEL, A. GORMAN HILLS, ALFRED M. SELLERS, CHARLES C. WOLFERTH, F.A.C.P.The Management of Essential HypertensionThe Medical Management of Arterial HypertensionThe Use of Rauwolif serpentina in Hypertensive Patients 1 December 1952Volume 37, Issue 6Page: 1144-1155KeywordsBlood pressureDietDrug administrationDrug therapyDrugsEtiologyHypertensionSodiumSympathectomyVasodilators ePublished: 1 December 2008 Issue Published: 1 December 1952 PDF downloadLoading ...