tbuckley/cabot-search huggingface dataset:
THE CLINICAL IMPLICATIONS OF THE THYMUS AND STATUS THYMICO-LYMPHATICUS
Authors: A. Graeme Mitchell, Estelle W. Brown
Journal: Annals of Internal Medicine (1934)

Article1 December 1934THE CLINICAL IMPLICATIONS OF THE THYMUS AND STATUS THYMICO-LYMPHATICUSA. GRAEME MITCHELL, M.D., F.A.C.P., ESTELLE W. BROWN, B.S.A. GRAEME MITCHELL, M.D., F.A.C.P.Search for more papers by this author, ESTELLE W. BROWN, B.S.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-8-6-669 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptOpinions concerning the clinical disturbances attributable to the thymus—to employ the metaphor of the pendulum—have swung from one end of the arc to the other; and the organ has been incriminated on the one hand as the cause of many symptoms, and on the other has been considered as relatively innocent and inoffensive. The truth of the matter probably lies somewhere between these two extremes, although it is not easy to know just where to arrest the pendulum. Confusion is increased by the fact that certain physicians, whose convictions must be received with respect, have expressed extreme views, sometimes doubting...Bibliography1. BOYD E: Growth of thymus; its relation to status thymico-lymphaticus and thymic symptoms, Am. Jr. Dis. Child., 1927, xxxiii, 867-879. Weight of thymus gland in health and in disease, ibid., 1932, xliii, 1162-1214. Google Scholar2. PANCOAST HK: Roentgenology of thymus in infancy and differential diagnoses of enlarged thymus and its treatment, Am. Jr. Med. Sci., 1930, clxxx, 745-767. CrossrefGoogle Scholar3. NOBACK GJ: Contribution to topographic anatomy of thymus gland, Am. Jr. Dis. Child., 1921, xxii, 120. Google Scholar4. PEARL R: Introduction to medical biometry and statistics, 1930, Second Edition, W. B. Saunders Co., Philadelphia, p. 439. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Cincinnati, Ohio*Read at the Chicago meeting of the American College of Physicians. April 20, 1934.From The Children's Hospital Research Foundation and the Department of Pediatrics, College of Medicine, University of Cincinnati. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byThymic death and meterological environment 1 December 1934Volume 8, Issue 6Page: 669-677KeywordsChildrenHospital medicinePediatricsThymus ePublished: 1 December 2008 Issue Published: 1 December 1934 PDF downloadLoading ...
Analysis of cytokine secretion from lymphocytes of patients with hypersensitivity reactions to contaminated heparins
Authors: M. Martin, H. Ott, H.F. Merk, B. Sachs
Journal: British Journal of Dermatology (2010)

Beginning in 2007, anaphylactoid reactions associated with unfractionated heparin (UFH) occurred and resulted in some fatalities. These reactions were reported to be linked to the complement and contact system activation induced by certain batches of UFH containing the adulterant oversulphated chondroitin sulphate (OSCS).Drug-specific secretion of selected cytokines from peripheral blood mononuclear cells (PBMC) of patients with hypersensitivity reactions to contaminated heparin was compared with the respective in vitro cytokine pattern of individuals with or without hypersensitivity to heparin, different glycosaminoglycans or other drugs.Study individuals (n = 13) were classified as follows: patients with hypersensitivity reactions to contaminated (OSCS) heparin (n = 3), noncontaminated heparin (n = 1) or other compounds (n = 3) and patients with ongoing heparin therapy without symptoms of intolerance (n = 2). Four healthy individuals served as controls. PBMC were incubated with six different glycosaminoglycan structures. Drug-specific intracellular interleukin (IL)-5, interferon (IFN)-γ and IL-10 production was investigated by flow cytometry, while secretion of IL-5, IL-2 and IFN-γ was analysed by enzyme-linked immunosorbent assay.PBMC from individuals with hypersensitivity reactions to contaminated heparin secreted considerable amounts of IL-2 in vitro. There was a suggestion that ongoing heparin therapy and the Li-heparin in the vials may have an impact on the lymphocyte reactivity of PBMC.The in vitro lymphocyte reactivity pattern of PBMC from individuals with hypersensitivity reactions to contaminated heparins was neither typical for an immune-mediated nor for a nonimmune-mediated reaction. Possible effects of heparins in the test system itself may require consideration.
A Double Blind Controlled Trial of N‐(3′, 4′‐Dimethoxycinnamoyl) Anthranilic Acid on Children with Bronchial Asthma
Authors: None Shioda
Journal: Allergy (1979)

A double blind controlled trial of N‐(3′, 4′‐dimethoxycinnamoyl) anchranilic acid (N‐5′) was carried out for treating children with bronchial asthma to determine its efficacy and safety. The results showed that the drug was significantly more effective in the N 10 and N 5 groups than in the N 0 group. Adverse reactions appeared only in one patient in the N 10 group who complained of slight anorexia while another patient in the N 0 group reported moderate diarrhoea. Moreover there was no indication of abnormality in further laboratory investigations. It can be therefore concluded that this drug is useful for the treatment of children with bronchial asthma.
Laser and intense pulsed light therapy for the treatment of hypertrophic scars: a systematic review
Authors: C. Vrijman, A.M. van Drooge, J Limpens, J.D. Bos, J.P.W. van der Veen, P.I. Spuls, A. Wolkerstorfer
Journal: British Journal of Dermatology (2011)

Summary Hypertrophic scars are difficult to improve and remain a therapeutic challenge. Several lasers and light sources have been evaluated in the past decades and have been shown to improve hypertrophic scars. However, a systematic review is not available. To assess current evidence of efficacy of all laser and intense pulsed light therapies used in the treatment of hypertrophic scars, we performed a systematic review searching electronic databases MEDLINE, EMBASE and CENTRAL. The quality of the controlled clinical trials was evaluated according to the Cochrane Collaboration’s tool for assessing risk of bias. Thirteen articles involving seven different lasers met the inclusion criteria. Most evidence was found for the pulsed dye laser (PDL) 585 nm (eight studies), followed by the PDL 595 nm (two studies), whereas limited evidence (one trial per laser) was available for the fractional nonablative laser 1540 nm, CO2 laser 10 600 nm, low-level laser therapy, Nd:YAG laser 532 nm and Erbium:YAG laser 2940 nm. Treatment recommendations should be formulated with caution as current evidence is insufficient for comparing the efficacy of different laser therapies. The PDL 585 nm showed a low efficacy for the treatment of hypertrophic scars. With moderate efficacy, the PDL 595 nm is promising, although more research is necessary. Little evidence was found for the efficacy of other lasers. Future research, with a low risk of bias, well-defined scar characteristics, validated outcome measures, standardized measurement methods, follow-up periods of at least 6 months and well-defined laser settings, is needed.
Annular Versus Subvalvular Approaches to Acute Ischemic Mitral Regurgitation
Authors: Tomasz A. Timek, David T. Lai, Frederick Tibayan, David Liang, Filiberto Rodriguez, George T. Daughters, Paul Dagum, Neil B. Ingels, Craig Miller
Journal: Circulation (2002)

Ischemic mitral regurgitation (IMR) has been attributed to annular dilatation, papillary muscle (PM) displacement ("apical leaflet tenting"), or both. We compared the efficacy of reducing annular or subvalvular dimensions to gain more mechanistic insight into acute IMR.Eight adult sheep underwent implantation of radiopaque markers on the LV, mitral annulus (MA), each leaflet edge, and each PM tip. Trans-annular septal-lateral (SL) and inter-PM tip sutures were placed and externalized. Biplane videofluoroscopy and transesophageal echocardiography were performed before and continuously during LCx occlusion-induced IMR with SL annular (SLAC) or inter-PM (PAPS) suture tightening (4 to 5 mm of cinching for 5 seconds during ischemia). MA SL dimension, inter-papillary distance (APM-PPM), and the distances between the anterior (APM) and posterior (PPM) PM tips and the mid-septal annulus ("saddle horn") were calculated from 3-D marker coordinates at end-systole.SLAC reduced IMR (grade=2.1+/-0.6 versus 0.7+/-0.5, P.001), SL annular diameter (4.9+/-2.5 mm smaller versus pre-cinching; P.001), and PM-"saddle horn" distances (0.9+/-0.7 and 1.0+/-0.8 mm reduction for APM and PPM, respectively; P.005). PAPS reduced APM-PPM distance (3.7+/-1.8 mm reduction versus precinching; P.001), only slightly decreased the PPM-"saddle horn" distance (0.3+/-0.3 mm reduction; P.03), and had no effect on IMR.Acute IMR was abolished by annular SL reduction, which also repositioned both PM tips closer to the mid-septal annulus and paradoxically increased leaflet "apical tenting"; reducing inter-papillary dimension was not effective, even though it displaced the leaflets toward the annular plane (less "apical tenting").
Traditional Risk Factors for Coronary Heart Disease—Reply
Authors: Umesh N. Khot, Monica B. Khot, Eric J. Topol
Journal: JAMA (2004)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Abstract 19627: A National Perspective of the Influence of Do-Not-Resuscitate Orders on In-Hospital Mortality and Adverse Outcome after Intracerebral Hemorrhage
Authors: Achint Patel, Sopan Lahewala, Neil Patel, Girish N Nadkarni, Grishma Dhaduk, Sudharani Busani, Alexandre M Benjo, Narayan Pokhrel, Chirag Bambhroliya, Shantanu Solanki, Manpreet S Sabharwal, Shilpkumar Arora, Abhimanyu Mahajan, Nilay Patel, Apurva Badheka, Vishal Jani, Umesh Gidwani, Syed I Hussain
Journal: Circulation (2014)

Background: The impact of do-not-resuscitate (DNR) orders on outcomes has not been systematically evaluated in Intracerebral Hemorrhage (ICH). Hypothesis: We assessed the impact of DNR orders in ICH and its association to mortality/related adverse outcomes. Methods: We reviewed the Healthcare Cost and Utilization Project’s Nationwide Inpatient Sample(NIS) database of 2011 for ICH using ICD 9-CM codes(431).This represents 20% of all US hospital patients and weighted numbers represent national estimates. We defined patients’ DNR status with ICD code V49.86 and comorbid conditions by Deyo’s modification of Charlson’s Comorbidity Index (CCI). We only included adult patients in our analysis. Our primary outcomes of interest were in-hospital mortality and adverse outcome (composite of mortality &amp; discharge other than home). We utilized chi-square test for univariable analysis for categorical variables and generated hierarchical multilevel regression models to determine independent predictors of mortality and adverse outcome. Results: We analyzed a total of 13440 pts (weighted n= 64617) with ICH of which 2029 (weighted n=9713) patients had DNR status. The proportions of mortality (56% vs. 19%, p&lt;0.001) and adverse outcome(89% vs 70%) were higher in patients with DNR orders. Even after adjusting for confounders (demographics, Deyo’s modification of charlson’s co-morbidity index, admission type (elective vs emergent), hospital region, hospital teaching status, hospital ICH volume and primary payer), DNR status was associated with higher in hospital mortality (OR 6.98, 95% CI 6.58-7.41), p&lt;0.001) and higher odds of adverse outcome (OR 3.98, 95% CI 3.64-4.34, p&lt;0.001). Conclusion: DNR status in patients admitted with ICH appears to be a independent and significant predictor of substantially increased hospital mortality and adverse outcomes. The reasons for this are multifactorial and likely involve patient as well as systematic factors.Further studies including both quantitative/qualitative aspects are warranted to investigate these factors in detail.
Insertion of β-satellite repeats identifies a transmembrane protease causing both congenital and childhood onset autosomal recessive deafness
Authors: Hamish S. Scott, Jun Kudoh, Marie Wattenhofer, Kazunori Shibuya, Asher Berry, Roman Chrast, Michel Guipponi, Jun Wang, Kazuhiko Kawasaki, Shuichi Asakawa, Shinsei Minoshima, Farah Younus, S. Qasim Mehdi, Uppala Radhakrishna, Marie-Pierre Papasavvas, Corinne Gehrig, Colette Rossier, Michael Korostishevsky, Andreas Gal, Nobuyoshi Shimizu, Batsheva Bonne-Tamir, Stylianos E. Antonarakis
Journal: Nature Genetics (2001)
Predictive Value of Microvolt T-Wave Alternans for Sudden Cardiac Death in Patients With Preserved Cardiac Function After Acute Myocardial Infarction
Authors: Takanori Ikeda, Hideaki Yoshino, Kaoru Sugi, Kaoru Tanno, Hiroki Shimizu, Jun Watanabe, Yuji Kasamaki, Akihiro Yoshida, Takao Kato
Journal: Journal of the American College of Cardiology (2006)
Antihypertensive Agents and Cardiovascular Events in Patients With Coronary Disease and Normal Blood Pressure
Authors: Victor Aboyans, Philippe Lacroix, Claude Cassat
Journal: JAMA (2005)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Correlation of mutation profile and response in patients with myelofibrosis treated with ruxolitinib
Authors: Keyur P. Patel, Kate J. Newberry, Rajyalakshmi Luthra, Elias Jabbour, Sherry Pierce, Jorge Cortes, Rajesh Singh, Meenakshi Mehrotra, Mark J. Routbort, Madan Luthra, Taghi Manshouri, Fabio P. Santos, Hagop Kantarjian, Srdan Verstovsek
Journal: Blood (2015)
Book: The Spirit Catches You and You Fall Down: A Hmong Child, Her American Doctors, and the Collision of Two Cultures
Authors: C. Richmond
Journal: BMJ (1999)

Anne Fadiman Farrar Straus and Giroux, £7.73, pp 352 ISBN 0374 525 641 Rating: ![Graphic][1]</img>![Graphic][2]</img>![Graphic][3]</img>![Graphic][4]</img> Merced is a town in a depressed area of California's central valley with a population of 61 000. A fifth of the population are Hmong refugees, and the proportion is growing as the Hmong value children and have plenty of them. Most of the older Hmong are illiterate, speak no English, and live on welfare benefits. The younger ones do well, rather better than white children in school and at university. No one knows where the Hmong originated; they are lighter than most Asian people and don't have an epicanthal fold to their eyes. They reached China over 1000 years ago, and in the past century responded to persecution by migrating on foot to … [1]: /embed/inline-graphic-1.gif [2]: /embed/inline-graphic-2.gif [3]: /embed/inline-graphic-3.gif [4]: /embed/inline-graphic-4.gif
Abstract #5500: HGF inhibited osteoblatogenesis via regulation of OPN mediated MAPK and NF-\#954;B pathways in MM
Authors: Juwon Park, Kwang-Sung Ahn, Chansu Lee, Eun-kyung Bae, Byung-Su Kim, Seonyang Park, Byoung Kook Kim, Sung-Soo Yoon
Journal: Cancer Research (2009)

Introduction: Hepatocyte growth factor (HGF) as a MET ligand activates mitogenic activation protein kinase leading to cell proliferation. In addition, osteopontin (OPN) activates uPA/uPAR mediated cell signaling leading to metalloproteinase activation. We found that HGF expression was correlated with OPN expression in serum of multiple myeloma patients. Interaction of HGF and OPN could play critical roles in progression of Multiple myeloma (MM). However, molecular mechanisms by which interaction between HGF mediated cell signaling and OPN mediated bone destruction still remain unknown. Materials and Methods: Levels of HFG and OPN were examined in serum of MM patient using ELISA. HGF-mediated JAK/MAPK activation and OPN mediated Wnt/b-catenin pathway was examined using western blot. To test HGF-mediated JAK/MAPK signaling and OPN mediated Wnt/b-catenin pathway, several sets of protein kinase inhibitors were used in three different MM cell lines (U266, RPMI8226, and IM-9 MM). Results: HGF activated ERK phosphorylation and STAT3 phosphorylation and their activation was diminished by MEK inhibitor and JAK inhibitor II. Dramatic changes in these activations and reductions were found in IM9 cells but not in U266 and RPMI8226 cells. Secretion of OPN via HGF was increased in IM9 cells but not in U266 and RPMI8226 cells. Blockage of MAPK pathway by PD98059 reduced the expression of OPN. Also, OPN mediated RUNX2 and BMP expression was slightly decreased in IM9 cells pre-treated with PD98059 for 2 hours. Exposure of exogenous OPN in these cells restored expression of OPN mediated RUNX2 and BMP. Also, expression levels of Dkk1 and Dkk2 were increased. Conclusion: HGF could contribute to MM progression (inhibition of osteoblast activity) via regulation of OPN expression. Thus, modulation of HGF induced activation of OPN mediated cell signaling pathway may be a potential target to treat bone destruction in MM patients.   Citation Information:  In: Proc Am Assoc Cancer Res; 2009 Apr 18-22; Denver, CO. Philadelphia (PA): AACR; 2009. Abstract nr 5500.
Abstract 2636: Connexin 43 suppresses tumor angiogenesis by downregulation of vascular endothelial growth factor
Authors: Man-Chin Chen, Che-Hsin Lee
Journal: Cancer Research (2014)

Abstract Gap junction intercellular communication (GJIC), which is performed by connexins, is crucial in the regulation of cellular functions. Connexin 43 (Cx43) is a general isoform expressed in most epithelial tissues especially in astrocytes. There were some studies indicated that Cx43 played a tumor suppressor which has been found in human tumors compared with adjacent normal tissues. Otherwise, there were some evidences showed that Cx43 overexpression affected metastasis. However, Cx43 plays a controversial role in tumor progression. Hypoxia, a hallmark of many solid tumors, is associated with angiogenesis and tumor progression. It activates a signal cascade that culminates in the stabilization of hypoxia-inducible factor 1 (HIF-1) transcription factor and activation of genes that possess hypoxia response elements (HRE). Herein, the loss of Cx43 was shown to stabilize HIF-1α, which is overexpressed in a majority of cancers and its overexpression correlates with poor prognosis and treatment failure. Meanwhile, we examined HIF-1α expression and activities in cancer cells with various Cx43 statuses. Loss of Cx43 expression in cancer cells resulted in increased HIF-1-dependent transcriptional activity and protein expression. In this study, we also found that Cx43 down-regulated VEGF and inhibited endothelial cell proliferation. Further work is warranted to understand the molecular mechanism leading to Cx43 effects by antiangiogenic signal pathway. Citation Format: Man-Chin Chen, Che-Hsin Lee. Connexin 43 suppresses tumor angiogenesis by downregulation of vascular endothelial growth factor. [abstract]. In: Proceedings of the 105th Annual Meeting of the American Association for Cancer Research; 2014 Apr 5-9; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2014;74(19 Suppl):Abstract nr 2636. doi:10.1158/1538-7445.AM2014-2636