EFFECT OF THE ANTIMONY COMPOUNDS, FUADIN AND TARTAR EMETIC, ON THE ELECTROCARDIOGRAM OF MAN; A STUDY OF THE CHANGES ENCOUNTERED IN 141 PATIENTS TREATED FOR SCHISTOSOMIASIS
Authors: Leonard Tarr
Journal: Annals of Internal Medicine (1947)

Article1 December 1947EFFECT OF THE ANTIMONY COMPOUNDS, FUADIN AND TARTAR EMETIC, ON THE ELECTROCARDIOGRAM OF MAN; A STUDY OF THE CHANGES ENCOUNTERED IN 141 PATIENTS TREATED FOR SCHISTOSOMIASISLEONARD TARRLEONARD TARRSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-27-6-970 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptINTRODUCTIONDuring 1945 there were admitted to Harmon General Hospital 488 patients with proved or suspected Schistosomiasis japonica acquired during the campaign on Leyte in the Philippines. These patients have been the subject of an intensive and detailed study.1Because the drugs tartar emetic (antimony potassium tartrate) and fuadin (antimony pyrocatechin disulfonate of sodium) used in the treatment of this disease have been reported to cause serious cardiovascular reactions and even death,2frequent electrocardiograms were taken during treatment to determine what changes might be expected. In a significant number of patients the changes in the electrocardiogram were striking and might...Bibliography1. MASONDANIELSPADDOCKGORDON PKWBFBH: Studies on Schistosomiasis japonica: The latent phase of Schistosomiasis japonica. To be published. Google Scholar2. MAINZERKRAUSE FM: Changes of the electrocardiogram appearing during antimony treatment, Trans. Roy. Soc. Trop. Med. and Hyg., 1940, xxxiii, 405. CrossrefGoogle Scholar3. TARR L: The effect of the antimony compounds, fuadin and tartar emetic, on the electrocardiogram, Bull. U. S. Army Med. Dept., 1946, v, 336. Google Scholar4. KHALIL M (a) : The specific treatment of human schistosomiasis, Arch. f. Schiffs. u. Trop. Hyg., 1931, xxxv. Quoted by.5 (b) Ibid., Jr. Egyptian Med. Assoc., 1936, xix, 285. Quoted by.2 Google Scholar5. SCHMIDTPETER HFM: Advances in the therapeutics of antimony, 1938, George Thieme, Leipzig, Germany. Reproduced by Alien Property Custodian, 1944, published by J. W. Edwards. CrossrefGoogle Scholar6. MASSON GA: The action of bismuth on the circulatory system, Jr. Pharmacol. and Exper. Therap., 1926, xxx, 39. Google Scholar7. AFRICASANTA CRUZ CMJL: Eggs of Schistosoma japonicum in the human heart. Vol. Jubilare Pro. Prof. Sadao Yoshida, Osaka, 1939, ii, 113. Google Scholar8. HEGGLINHOLZMANN RM: Die klinische Bedeutung der verlängerten QT-Distanz (Systolendauer) im Elektrocardiogramm, Ztschr. f. klin. Med., 1937, cxxxii, 1. Google Scholar9. GOODMANGILMAN LA: The pharmacologic basis of therapeutics, 1941, The Macmillan Co., N. Y. Google Scholar10. WEESE H: Important pharmaceutical aspects of solustibosan, Chinese Med. Jr., 1937, lii, 421. Quoted by.5 Google Scholar11. KHALIL M: Excretion of drugs: its influence on therapeutic results with special reference to antimony treatment of schistosomiasis, Lancet, 1936, ccxxxi, 132. CrossrefGoogle Scholar12. LUCIABROWN SPJW: Effects of potassium antimonyl-tartrate on blood and hematopoietic organs, Jr. Pharmacol. and Exper. Therap., 1934, lii, 418. Google Scholar13. BRADLEYFREDRICK WRWG: The toxicity of antimony, Indust. Med., 1941, x, 15. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: M.C. New York, N. Y.*Received for publication January 25, 1947.From the Army Service Forces—8th Service Command, Harmon General Hospital. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byCardiovascular Effects of Environmental Metal Antimony: Redox Dyshomeostasis as the Key Pathogenic DriverEsquistossomose e o Coração - Em Nome das Doenças Tropicais Negligenciadas e Outras Doenças Infecciosas que Afetam o Coração (Projeto NET-Heart)The effect of potassium antimonyl tartrate on the γ-aminobutyric acid and acetylcholine contents in the cerebral hemispheres of normal and Schistosoma mansoni infected miceMortality in a cohort of antimony smelter workersCardiotoxic effects of antimony dimercaptosuccinate in schistosomiasisELECTROCARDIOGRAPHIC EFFECTS OF ANTIMONY DIMERCAPTO-SUCCINATE (`ASTIBAN')THE EFFECT OF ANTIMONY DIMERCAPTO-SUCCINATE ON THE ELECTROCARDIOGRAMCORONARY MIMICRY: NORMAL VARIANTS, AND PHYSIOLOGIC, PHARMACOLOGIC AND PATHOLOGIC INFLUENCES THAT SIMULATE CORONARY PATTERNS IN THE ELECTROCARDIOGRAM*HENRY J. L. MARRIOTT, M.D.FUADIN THERAPY OF SCHISTOSOMIASIS ASSOCIATED WITH VENTRICULAR TACHYCARDIA AND DEATH: A CASE REPORT*ROBERT SCHICK, M.D., ARNOLD B. RITTERBAND, M.D., AMOS H. LIEBERMAN, M.D.A report on the intensive treatment of vesical schistosomiasis 1 December 1947Volume 27, Issue 6Page: 970-988KeywordsAntimonyCardiovascular diseasesDrugsElectrocardiographyPotassiumSchistosomiasisSodium ePublished: 1 December 2008 Issue Published: 1 December 1947 PDF downloadLoading ...