PERNICIOUS ANEMIA WITH NORMAL BLOOD PICTURE
Authors: Conley H. Sanford
Journal: Annals of Internal Medicine (1935)

Article1 August 1935PERNICIOUS ANEMIA WITH NORMAL BLOOD PICTURECONLEY H. SANFORD, M.D., F.A.C.P.CONLEY H. SANFORD, M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-9-2-189 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptIt appears established, from the experiments of Castle and his co-workers,1, 2, 3that pernicious anemia is a deficiency disease due to the absence of an intrinsic factor of undetermined nature in the gastric secretion. This intrinsic factor is definitely not hydrochloric acid, though its absence is practically always associated with absence of free hydrochloric acid in the stomach contents. It is well known that this deficiency exerts its influence chiefly on the blood-forming organs and the nervous system. It is a fact, though in my opinion not uniformly appreciated by clinicians and hematologists, that these two systems may be...References1. CASTLE WB: Observations on the etiologic relationship of achylia gastrica to pernicious anemia, Am. Jr. Med. Sci., 1929, clxxviii, 748-764. CrossrefGoogle Scholar2. CASTLETOWNSEND WBWC: Observations on the etiologic relationship of achylia to pernicious anemia, Am. Jr. Med. Sci., 1929, clxxviii, 764-777. CrossrefGoogle Scholar3. CASTLEHEATHSTRAUSS WBCWMB: Observations on the etiologic relationship of achylia gastrica to pernicious anemia, Am. Jr. Med. Sci., 1931, clxxxii, 741-764. CrossrefGoogle Scholar4. MCCANNMAITLAND-JONES WSAG: Text-book of medicine, Cecil, 1928, W. B. Saunders Co., Philadelphia. Google Scholar5. ORDWAYGORHAM TLW: Oxford monograph on diagnosis and treatment of diseases of the blood, Oxford University Press, 1930, ix, 65. Google Scholar6. DAVIDSONGULLAND LSGL: Pernicious anemia, 1930, C. V. Mosby Co., St. Louis. CrossrefGoogle Scholar7. WOLTMANN HW: The nervous symptoms in pernicious anemia; a analysis of 150 cases, Am. Jr. Med. Sci., 1919, clvii, 400. CrossrefGoogle Scholar8. MINOTMURPHY GRWP: A diet rich in liver in the treatment of pernicious anemia, Jr. Am. Med. Assoc., 1927, lxxxix, 759-766. CrossrefGoogle Scholar9. TENNEYGOLDSTEIN CFE: The mental symptoms of pernicious anemia and their response to liver therapy, Med. Clin. N. Am., 1933, xvii, 185-191. Google Scholar10. UNGLEYSUZMAN CCMW: Subacute combined degeneration of the cord: symptomatology and effects of liver therapy, Brain, 1929, lii, 271-294. CrossrefGoogle Scholar11. GARVEYLEVINGULLER PHPMEI: The effect of liver therapy on the neurologic aspects of pernicious anemia, ANN. INT. MED., 1933, vi, 1441-1448. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Memphis, Tennessee*Received for publication October 12, 1934. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byAbsorption of Radioactive Vitamin B 12 in Nonanemic Patients with Combined-System DiseasePernicious Anemia * 1 August 1935Volume 9, Issue 2Page: 189-194KeywordsBloodHematology and oncologyHydrochloric acidNervous systemPernicious anemiaStomach ePublished: 1 December 2008 Issue Published: 1 August 1935 PDF downloadLoading ...