tbuckley/cabot-search huggingface dataset:
Gender discrimination is blamed for high rates of uterine prolapse in Nepal
Authors: A. Gulland
Journal: BMJ (2014)

Around 10% of women in Nepal experience uterine prolapse because of “widespread and systemic” gender discrimination, says the human rights organisation Amnesty International.

In a report on the condition Amnesty said that the problem was particularly prevalent in countries such as Nepal, where access to healthcare was poor and gender discrimination was common.1

Amnesty quoted a report by the United Nations Population Fund published in 2006,2 which found that around one in 10 …
A PLEA FOR THE GENERAL ADOPTION OF A PLAN OF HOSPITAL ORGANIZATION THAT WILL RELEASE COMPETENT PHYSICIANS FOR ARMY SERVICE
Authors: S. S. Goldwater
Journal: JAMA (1918)

<h3>To the Editor:</h3> —The United States is now in the war. The nation is getting its stride. The changes and readjustments that are required for the effective conduct of the war are difficult, and are becoming more difficult every day, but they are never impossible. Of necessity, the business of the country has been reorganized; the same imperious necessity calls for the reorganization of the civil hospitals. Up to the present time, the enrolment of medical men has kept pace with the Army's growth. But a million Americans have now taken their place in the fighting line; ships are available for the rapid transportation of a second million; a third million is streaming into the training camps, and more doctors are needed. The hospitals of the country must help to furnish them—they can if they will. By undertaking to retain in its service only the actual number of men required
A CASE OF ATROPHY OF THE PHALANGES OF THE HANDS WITH JOINT LESIONS: SEQUENTIAL TO MULTIPLE TUMOURS OF THE SKIN
Authors: B. Watson
Journal: BMJ (1906)

TN BLm 553 case of disease not at the time attending the clinique is shown on the screen by the lantern.The exllibition of lantern slides is most useful also for illustrating eye diseases in groups, and of showing instances of interest either by their rarity or otherwise.Again, repeating by the lantern ofi the screen what lhas already been demon- strated on patients is found practically to be a most valuable means of impressing the facts on the mind of the student.In a few leetures on this plan the student can be showni points of all important diseases of the eye which will enable him to acquire a good, practical, working knowledge of eye work.
TNP-470 inhibits oxidative stress, nitric oxide production and nuclear factor kappa B activation in a rat model of hepatocellular carcinoma
Authors: F. Jorquera, J.L. Mauriz, P. Linares, J.L. Olcoz, R.I.R. Macias, P. Gonzalez, J. Gonzalez-Gallego
Journal: Journal of Hepatology (2003)
Reticulated platelet counts in patients undergoing autologous bone marrow transplantation: An aid in assessing marrow recovery
Authors: Katherine G. Romp, William P. Peters, Maureane Hoffman
Journal: American Journal of Hematology (1994)

Thiazole orange (TO) is a fluorescent dye that is commonly used for flow cytometric measurement of erythrocytic reticulocytes. This technique has also been validated for counting "reticulated" platelets, as a measure of bone marrow thrombopoietic activity. Patients with an established diagnosis of idiopathic thrombocytopenic purpura (ITP) have been reported to have a three- to five-fold increase in the percent of circulating reticulated platelets. The current study was conducted to determine if platelet reticulocyte counts predicted recovery of bone marrow thrombopoietic activity following autologous bone marrow transplantation. We found an increase in the percent of circulating reticulated platelets preceding recovery of the platelet count; then, as the patients' platelet counts rose, the percent reticulated platelets fell. In patients with prolonged thrombocytopenia, a persistent increase in the proportion of reticulated platelets suggested a consumptive process, as opposed to failure of engraftment. Moderate transfusion of platelet concentrates did not interfere with the ability of the platelet reticulocyte measurements to detect increased thrombopoietic activity. Platelet transfusions did obscure any decrease in the proportion of reticulated platelets. Our results show that platelet reticulocyte counts could be useful in monitoring the recovery of marrow function following autologous bone marrow transplantation.
Unsedated Transnasal Percutaneous Endoscopic Gastrostomy Placement in Selected Patients
Authors: M. A. Vitale, G. Villotti, L. D'Alba, M. A. De Cesare, S. Frontespezi, G. Iacopini
Journal: Endoscopy (2005)

Background and Study Aims: The placement of a percutaneous endoscopic gastrostomy (PEG) is the procedure of choice for the long-term management of dysphagic patients with neurological disease or with trauma or tumors of the head and neck. It is not always possible to perform conventional upper gastrointestinal endoscopy in such patients due to stenosis and/or occlusion of the mouth or pharynx and/or partial or complete trismus. The aim of this study was to show whether transnasal esophagogastroduodenoscopy (EGD) offers a feasible and effective alternative method for PEG placement in these selected patients. Patients and Methods: PEG placement was required for 155 patients at our institution during a 27-month period. In 12 patients oral access of an endoscope into the esophagus was not possible. Unsedated transnasal EGD (T-EGD) was then performed using an ultrathin video gastroscope, which had a distal-end diameter of 5.9 mm. A 16-Fr polyurethane PEG tube with a conical, flexible, soft distal end and a collapsible bumper was used in all cases. The Gauderer-Ponsky pull technique was used for PEG placement. Results: T-EGD and perendoscopic transnasal placement of a PEG tube was successfully performed in all 12 patients. No patient required sedation during the procedure. No immediate or late-onset procedure-related complications occurred in any of the 12 patients. Conclusions: In some dysphagic patients in whom the oral route is not accessible with a standard endoscope, a transnasal endoscopic approach allows the placement of a PEG tube. In these selected patients this technique has been shown to be safe and effective and does not require the use of sedation.
Abstract PD10-06: Concordance in Hormone Receptors and HER2 Expression between Primary Breast Cancer, Loco-Regional Recurrences and Distant Metastases. Subgroups Analysis and Predictors of Discordance
Authors: FE Petracci, MV Costanzo, AA Nervo, J Nadal, M Amat, E Domenichini, RD. Chacón
Journal: Cancer Research (2010)

Abstract Background. Retrospective reviews and small prospective studies have shown that hormone receptor (HR) and HER2 status may change between primary breast cancer and recurrences in 15 to 40% and 0 to 34% respectively. This may lead to changing treatment in 15 to 20% of patients (pts). The primary aim of this study is to evaluate the discordance in HR and HER2 status between primary tumors, loco-regional recurrences (LRR) and distance metastasis (mets, DM). Secondary objective is to identify predictors of discordance. Patients and Methods. Retrospective analysis of patients with invasive breast cancer with biopsy of suspicious metastatic lesion. HR status (estrogen and/or progesterone) was defined as positive (HR+ve) when immunohistochemistry (IHC) staining was ≥10% of cells. HER2 positive (HER2+ve) was defined by IHC 3+ or amplified by fluorescence in situ hibridization (FISH). Results. Two hundred and fifty one pts were evaluated with two hundred biopsies available for analysis. Median follow-up was 77 months (range, 2.5 — 415.1). 59% of primary tumors were HR+ve/HER2-ve, 27% triple negative (TN), 9% triple positive (TP) and 5% HR-ve/HER2+ve. 75.5% of patients received adjuvant chemotherapy, 5.0% primary chemotherapy, 78% adjuvant radiation and 44% hormonal therapy. 12 pts developed secondary breast cancer before recurrence. 50% (131) of recurrences were LRR and 50% were DM (17% visceral, 27% non-visceral and 2% central nervous system mets). LRR or DM surgery was performed in 33% of patients. We observed a 21% of discordance for HR (18% negative to positive and 28% positive to negative) and 6% of discordance for HER2 (5% negative to positive and 6% positive to negative). The overall discordance in HR/HER2 subgroups was 22%. No statistical differences (p .27) were observed in HR/HER2 subgroups’ discordance between LRR (median time to LRR, 43.5 months) and DM (median time to DM, 58 months). Greatest discordance was seen in TN tumors (31%), follow by HR-ve/HER2+ve, TP and HR+ve/HER2-ve with 28.5%, 25% and 17% respectively. Neither of TP tumors nor of 3 patients treated with trastuzumab became negative for HER2. At multivariate analysis, recurrence free interval longer than 24 months was the only statistical predictor of discordance (p .02). Conclusions. Considering the high percentage of receptors status discordance and current options of systemic treatments, including target therapies, tissue confirmation and HR/HER2 analysis should be recommended for patients with suspicious of loco-regional or distant mets. Citation Information: Cancer Res 2010;70(24 Suppl):Abstract nr PD10-06.
Risks to Health Care Workers in Developing Countries
Authors: C Sagoe-Moses, R D Pearson, J Perry, J Jagger
Journal: New England Journal of Medicine (2001)

The first report of a health care worker infected with the human immunodeficiency virus (HIV) by a needle stick, published in the medical literature in 1984,1 launched a new era of concern about the occupational transmission of blood-borne pathogens. In the United States, universal precautions were implemented,2 regulations such as the Bloodborne Pathogens Standard were issued,3 and the rate of vaccination against hepatitis B virus (HBV) among health care workers increased dramatically.4 After a decade of phenomenal technological advances in sharp devices engineered for safety, the federal Needlestick Safety and Prevention Act, requiring the use of safer devices, became law . . .
Follow up of quality of public oriented health information on the world wide web: systematic re-evaluation
Authors: Chiara Pandolfini, Maurizio Bonati
Journal: BMJ (2002)

website's contents and they were converted into three accuracy levels.In level I, more than two thirds of guideline statements were covered (28/121 (24%) websites); in level II, one third to two thirds of guideline statements were covered (43 (35%) websites); in level III, less than one third of guideline statements were covered (50 (41%) websites).We examined the relation between features of website credibility and level of accuracy of contents by cross tabulation and assessed the strength of association with Kendall's rank correlation, which adjusts for tied ranks in the data.The value of the coefficient (tau b) ranges from -1 to 1. Interpretation is subjective, but values near zero may be taken to indicate no correlation whereas values near 1 indicate a strong correlation.As shown in the table, websites with description of credibility features tended to have higher levels of accuracy of contents, but this relationship was not strong. CommentOur study shows that features of website credibilitysource, currency, and evidence hierarchy-have only slight or at best moderate correlation with accuracy of information in five common health topics.Thus, apparently credible websites may not necessarily provide higher levels of accurate health information.We thank Julie Morris for statistical input.
More than skin deep: atherosclerosis as a systemic manifestation of psoriasis
Authors: A.B. Alexandroff, M. Pauriah, R.D.R. Camp, C.C. Lang, A.D. Struthers, D.J. Armstrong
Journal: British Journal of Dermatology (2009)

Journal Article More than skin deep: atherosclerosis as a systemic manifestation of psoriasis Get access A.B. Alexandroff, A.B. Alexandroff Department of Dermatology, Leicester Royal Infirmary, Leicester LE1 5WW, U.K. Correspondence: Anton B. Alexandroff. E‐mail: anton.alexandroff@gmail.com Search for other works by this author on: Oxford Academic Google Scholar M. Pauriah, M. Pauriah Division of Medicine and Therapeutics, Department of Clinical Pharmacology, University of Dundee, Ninewells Hospital and Medical School, Dundee, U.K. Search for other works by this author on: Oxford Academic Google Scholar R.D.R. Camp, R.D.R. Camp Department of Infection, Immunity and Inflammation, University of Leicester, Leicester, U.K. Search for other works by this author on: Oxford Academic Google Scholar C.C. Lang, C.C. Lang Division of Medicine and Therapeutics, Department of Clinical Pharmacology, University of Dundee, Ninewells Hospital and Medical School, Dundee, U.K. Search for other works by this author on: Oxford Academic Google Scholar A.D. Struthers, A.D. Struthers Division of Medicine and Therapeutics, Department of Clinical Pharmacology, University of Dundee, Ninewells Hospital and Medical School, Dundee, U.K. Search for other works by this author on: Oxford Academic Google Scholar D.J. Armstrong D.J. Armstrong Department of Rheumatology, Altnagelvin Hospital, Londonderry, U.K. Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 161, Issue 1, 1 July 2009, Pages 1–7, https://doi.org/10.1111/j.1365-2133.2009.09281.x Published: 01 July 2009
Efforts to Diversify the Academic Pediatric Workforce–—Reply
Authors: Leslie R. Walker, F. Bruder Stapleton
Journal: JAMA Pediatrics (2014)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Pediatrics HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Pediatrics journal
MRI‐Visual Order–Disorder Micellar Nanostructures for Smart Cancer Theranostics
Authors: Hirak K. Patra, Nisar Ul Khaliq, Thobias Romu, Emilia Wiechec, Magnus Borga, Anthony P. F. Turner, Ashutosh Tiwari
Journal: Advanced Healthcare Materials (2013)

The development of MRI‐visual order–disorder structures for cancer nanomedicine explores a pH‐triggered mechanism for theragnosis of tumor hallmark functions. Superparamagnetic iron oxide nanoparticles (SPIONs) stabilized with amphiphilic poly(styrene)‐ b ‐poly(acrylic acid)‐doxorubicin with folic acid (FA) surfacing are employed as a multi‐functional approach to specifically target, diagnose, and deliver drugs via a single nanoscopic platform for cancer therapy. The functional aspects of the micellar nanocomposite is investigated in vitro using human breast SkBr3 and colon cancer HCT116 cell lines for the delivery, release, localization, and anticancer activity of the drug. For the first time, concentration‐dependent T 2 ‐weighted MRI contrast for a monolayer of clustered cancer cells is shown. The pH tunable order–disorder transition of the core–shell structure induces the relative changes in MRI contrast. The outcomes elucidate the potential of this material for smart cancer theranostics by delivering non‐invasive real‐time diagnosis, targeted therapy, and monitoring the course and response of the action before, during, and after the treatment regimen.
Oxygen therapy in acute medical care
Authors: A. J Thomson
Journal: BMJ (2002)

The potential dangers of hyperoxia need to be recognised 

Oxygen is cheap, widely available, and used in a range of settings and conditions to relieve or prevent tissue hypoxia. Since its discovery by Scheele and Priestley in the 1770s, it has remained one of the most effective therapeutic agents available. However, as a result of poor prescribing and monitoring, inappropriate doses are often given.1

Oxygen is most commonly delivered by devices with variable performance such as face masks and nasal cannulae. These can produce unexpectedly high concentrations of inspired oxygen, particularly when ventilation is depressed.2 In addition, masks that incorporate a reservoir bag are often used in emergencies, following the widespread adoption of advanced trauma life support style (or ATLS) guidelines. These appliances can produce systemic hyperoxia that is generally assumed to be harmless. However, emerging evidence suggests that for some patients with acute medical conditions, hyperoxia may be harmful.

Oxygen therapy is often …
Control of Environmental Lung Disease
Authors: Arend Bouhuys, John M. Peters
Journal: New England Journal of Medicine (1970)

ENVIRONMENTAL lung disease is an important source of ill-health, disability and death that can he greatly reduced by preventive measures. We review the problem, basing ourselves on a document prepared, by one of us (A.B.), for the Task Force on Research Planning in Environmental Health Science.† The assignment focused on occupational exposures as a cause of lung disease; general atmospheric pollution is beyond our scope.Harriet L. Hardy and J. E. Leahy1 have described some of the difficulties in recognizing occupational lung disease in the United States. There has been lack of action on the part of many who should . . .
1026-58 The effectiveness of distal-protect devices in patients with acute coronary syndromes: The relationship between coronary thrombus and thrombolysis in myocardial infarction frame counts after percutaneous coronary interventions
Authors: Kentaro Okamatsu, Kyoichi Mizuno, Shunta Sakai, Shinya Yokoyama, Takayoshi Ohba, Koji Seimiya, Masamichi Takano, Shigenobu Inami, Junko Sano, Noritake Hata
Journal: Journal of the American College of Cardiology (2004)
Induced Pluripotent Stem Cells
Authors: Kitchener D. Wilson, Joseph C. Wu
Journal: JAMA (2015)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Abstract 579: Chinese herbal mixture LQ inhibits tumor growth and metastasis and increases survival in orthotopic and other mouse models of human and mouse cancer
Authors: Lei Zhang, Chengyu Wu, Yong Zhang, Xiaoen Wang, Jose Reynoso, Fang Liu, Ming Zhao, Robert M. Hoffman
Journal: Cancer Research (2010)

Abstract Natural products have been used as sources of first-line cancer chemotherapeutic agents, including vinca alkaloids, taxanes, podophyllotoxin and camptothecin. However, Traditional Chinese Medicine (TCM) combinations (Fufang), which have been widely used in China for over 5000 years, are still poorly understood with regard to the types of cancer they are effective against as well as their mechanism of action. We report here on the use of patient-like orthotopic nude-mouse models of metastatic cancer and other mouse tumor models to obtain proof-of-concept that TCM (Fufang) combinations have anti-tumor and anti-metastatic activity. In the present study, human and mouse lung, pancreatic and prostate cancer cell lines (H460, Lewis lung carcinoma [LLC) MIA-PaCa-2 and PC-3, respectively), labeled with red fluorescent protein (RFP) or green fluorescent protein (GFP), were orthotopically implanted or injected subcutaneously, or injected in the tail vein in nude mice to evaluate anti-tumor and anti-metastatic efficacy of the Fufang LQ, which contains a mixture of herbs. Results showed that LQ (gavage, 600 mg/kg/day) significantly inhibited prostate, pancreatic and lung cancer tumor growth as measured by imaging, tumor size and weight, in both subcutaneous and metastatic models. LQ was efficacious against primary and metastatic cancer without weight loss in contrast to drugs such as doxorubicin and cisplatin, which caused significant weight loss. Survival of tumor-bearing mice was also prolonged by LQ treatment. Furthermore, in vitro experiments demonstrated that LQ inhibited proliferation of tumor cells (LLC, H460, PC-3 and MIA-PaCa-2) in a dose-dependent manner. Those results indicate that LQ has efficacy against metastatic pancreatic and lung and prostate cancer which demonstrates its clinical potential. The results also suggest that GFP- and RFP-expressing tumors in orthotopic and other nude mouse models can be widely used for in vivo evaluation of TCM. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 101st Annual Meeting of the American Association for Cancer Research; 2010 Apr 17-21; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2010;70(8 Suppl):Abstract nr 579.
Attention: A Case of Munchausen Syndrome
Authors: ALFRED E. BUXTON
Journal: Annals of Internal Medicine (1972)

Letters, Comments, and Corrections1 September 1972Attention: A Case of Munchausen SyndromeALFRED E. BUXTON, JOEL D. MEYERS, M.D., LAURENCE B. GARDNER, M.D.ALFRED E. BUXTONSearch for more papers by this author, JOEL D. MEYERS, M.D.Search for more papers by this author, LAURENCE B. GARDNER, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-77-3-477_1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: On 7 May 1972, T.G., a 28-year-old Italian man was admitted to the Hospital of the University of Pennsylvania with a chief complaint of chest pain and shortness of breath of several hours' duration. He stated that he had discontinued his digoxin and warfarin 5 days before admission and that he had been recently hospitalized in Denver, Colorado, for "heart failure." He also related an extensive series of hospitalizations primarily in the New York City area, with discharge diagnoses that included tuberculosis, sarcoidosis, pulmonary fibrosis, multiple pulmonary emboli, myocardial infarction, thrombophlebitis, and cryoglobulinemia. He denied any medical... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: ALFRED E. BUXTON; JOEL D. MEYERS, M.D.; LAURENCE B. GARDNER, M.D.Affiliations: Hospital of the University of Pennsylvania Philadelphia, Pa. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byCardiac Munchausen SyndromeMore on "Munchausen Syndrome"RICHARD B. DEVEREUX, M.D., THOMAS R. MILLER, M.D. 1 September 1972Volume 77, Issue 3Page: 477-477KeywordsDyspneaHeart failureHospitalizationsIschemiaMyocardial infarctionPulmonary fibrosisSarcoidosis ePublished: 1 December 2008 Issue Published: 1 September 1972 PDF downloadLoading ...