The Current Status of Diphenylhydantoin in Heart Disease
Authors: E N Mercer, J A Osborne
Journal: Annals of Internal Medicine (1967)

Review1 November 1967The Current Status of Diphenylhydantoin in Heart DiseaseEDWARD N. MERCER, B.A.SC., M.D., F.R.C.P.(C), JOHN A. OSBORNE, B.SC., M.D.EDWARD N. MERCER, B.A.SC., M.D., F.R.C.P.(C), JOHN A. OSBORNE, B.SC., M.D.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-67-5-1084 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptDiphenylhydantoin sodium (Dilantin®) is being widely investigated for the treatment of cardiac arrhythmias. The drug appears to offer some advantages, particularly with regard to safety, over other forms of drug therapy. Nonetheless, its use carries certain hazards, some of which may not be widely appreciated. The range of therapeutic usefulness of the drug in heart disease is becoming established, and its mode of action, although not yet fully elucidated, is undergoing intensive investigation. 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Author, Article, and Disclosure InformationAffiliations: Vancouver,From Vancouver General Hospital and The University of British Columbia, Vancouver, British Columbia, Canada.Dr. Mercer was supported in this study by a medical research fellowship from the Canadian Heart Foundation, Toronto, Ontario.Requests for reprints should be addressed to John A. Osborne, M.D., Director of Cardiology, Vancouver General Hospital, Vancouver 9, British Columbia, Canada.*Diphenylhydantoin (Dilantin®) is approved by the U. S. Food and Drug Administration for use only as an anticonvulsant; at present in the United States the use of this drug in the treatment of cardiac arrhythmias is investigational only. 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PodiumsgesprächCurrent status of diphenylhydantoinSome aspects of interaction between diphenylhydantoin and digoxin by simultaneous administration to dogsThe depressant action of diphenylhydantoin on electrical and mechanical properties of isolated rabbit and dog atria: Dependence on sodium and potassiumThe effect of glucagon on arrhythmias due to digitalis toxicityThe effect of diphenylhydantoin on atrioventricular and intraventricular conduction in manRecognition and therapy of digitalis toxicityRecognition and therapy of digitalis toxicityClinical Use of Antiarrhythmic DrugsEffects of Diphenylhydantoin on Excitability and Automaticity in the Canine HeartDiphenylhydantoin: Pharmacological and clinical useEffects of Tetanization on Transmitter DynamicsA method for estimation of plasma diphenylhydantoin concentrationThe clinical use of diphenylhydantoin (Dilantin) in the treatment and prevention of cardiac arrhythmiasAtrial Flutter with One-to-One ConductionLIGNOCAINE IN THE MANAGEMENT OF VENTRICULAR ARRHYTHMIASUnterdrückung von Arrhythmien infolge Glykosid-Intoleranz mit DiphenylhydantoinActions of Diphenylhydantoin on the Electrical Properties of Isolated Rabbit and Canine AtriaElectrophysiological Effects of Direct Current Countershock before and after Ouabain Sensitization and after Diphenylhydantoin Desensitization in the Dog 1 November 1967Volume 67, Issue 5Page: 1084-1107KeywordsAnticonvulsantsArrhythmiaCardiovascular therapyDrug therapyDrugsFood and Drug AdministrationHeartLongitudinal studiesSafetySodium ePublished: 1 December 2008 Issue Published: 1 November 1967 PDF downloadLoading ...