tbuckley/cabot-search huggingface dataset:
Single Circulating Tumor Cell Detection and Overall Survival in Non Metastatic Breast Cancer.
Authors: F. Bidard, C. Mathiot, F. Mefti, S. Delaloge, S. Giacchetti, R. Salmon, L. Mignot, B. Sigal-Zafrani, A. Vincent-Salomon, O. Tembo, M. Marty, J. Pierga
Journal: Cancer Research (2009)

Abstract Background: Circulation of cancer cells in the blood is a necessary step of hematogeneous metastasis while circulating tumor cells (CTC) have been reported to have a low metastatic efficiency in preclinical animal models. After a median follow-up of 18 months, we previously reported that CTC detection influences the distant metastasis-free survival (DMFS) in non-metastatic breast cancer (BC) patients (pts) treated by neoadjuvant chemotherapy (NACT) in a multicenter prospective trial. Updated results are presented here, focusing on overall survival (OS) and predictors of metastatic relapse.Methods: In 115 localized BC pts, CTC were prospectively screened (CellSearch) before and after NACT (REMAGUS02). We analyzed their outcome after a median follow-up of 36 months.Results: At baseline, 23% of pts were CTC-positive, but only 10% had more than 1 CTC per 7.5ml of blood. At an individual level, CTC detection before chemotherapy, used as a test to predict metastatic relapse, exhibited a global accuracy of 77%, higher than that of tumor grade (54%), tumor size (57%), lymph node invasion (40%), triple negative phenotype (76%) and pathological complete response (27%). Multivariate analyses for OS and DMFS showed that CTC detection before chemotherapy was a strong independent prognostic factor for both DMFS (p=0.01, RR=5.0, 95%CI[1.4-17]) and OS (p=0.007, RR=9, 95%CI[1.8-45]), along with tumor size and triple-negative phenotype, while post-chemotherapy CTC detection had a lower significance for both endpoints (p=0.07 and p=0.09 respectively).Conclusion: Biologically, the metastatic efficiency of CTC could be higher than previously thought. Clinically, besides confirming our previously reported results, this study shows that CTC detection may become the main prognostic factor in BC pts treated with NACT. Implementing this technique in everyday management might help to identify high-risk pts in whom innovative strategies should be investigated.Supported by PHRC AOM/2OO2/02117, Pfizer inc., Roche, sanofi-aventis.ISRCTN10059974 Citation Information: Cancer Res 2009;69(24 Suppl):Abstract nr 3017.
Comparative Effectiveness of Multivessel Coronary Bypass Surgery and Multivessel Percutaneous Coronary Intervention
Authors: Mark A. Hlatky, Derek B. Boothroyd, Laurence Baker, Dhruv S. Kazi, Matthew D. Solomon, Tara I. Chang, David Shilane, Alan S. Go
Journal: Annals of Internal Medicine (2013)

Chinese translation Background: Randomized trials of coronary artery bypass graft (CABG) surgery and percutaneous coronary intervention (PCI) suggest that patient characteristics modify the effect of treatment on mortality. Objective: To assess whether clinical characteristics modify the comparative effectiveness of CABG versus PCI in an unselected, general patient population. Design: Observational treatment comparison using propensity score matching and Cox proportional hazards models. Setting: United States, 1992 to 2008. Patients: Medicare beneficiaries aged 66 years or older. Intervention: Multivessel CABG or multivessel PCI. Measurements: The CABG–PCI hazard ratio (HR) for all-cause mortality, with prespecified treatment-by-covariate interaction tests, and the absolute difference in life-years of survival in clinical subgroups after CABG or PCI, both over 5 years of follow-up. Results: Among 105 156 propensity score–matched patients, CABG was associated with lower mortality than PCI (HR, 0.92 [95% CI, 0.90 to 0.95]; P < 0.001). Association of CABG with lower mortality was significantly greater (interaction P ≤ 0.002 for each) among patients with diabetes (HR, 0.88), a history of tobacco use (HR, 0.82), heart failure (HR, 0.84), and peripheral arterial disease (HR, 0.85). The overall predicted difference in survival between CABG and PCI treatment over 5 years was 0.053 life-years (range, −0.017 to 0.579 life-years). Patients with diabetes, heart failure, peripheral arterial disease, or tobacco use had the largest predicted differences in survival after CABG, whereas those with none of these factors had slightly better survival after PCI. Limitation: Treatments were chosen by patients and physicians rather than being randomly assigned. Conclusion: Multivessel CABG is associated with lower long-term mortality than multivessel PCI in the community setting. This association is substantially modified by patient characteristics, with improvement in survival concentrated among patients with diabetes, tobacco use, heart failure, or peripheral arterial disease. Primary Funding Source: National Heart, Lung, and Blood Institute.
Granuloma annulare and sarcoidosis
Authors: PABLO UMBERT, R.K. WINKELMANN
Journal: British Journal of Dermatology (1977)

Journal Article Granuloma annulare and sarcoidosis Get access PABLO UMBERT, PABLO UMBERT Mayo Clinic and Mayo Foundation, Rochester, Minnesota Dr P.Umbert, c/o Section of Publications, Mayo Clinic, 200 First Street SW, Rochester, MN 55901, U.S.A. Search for other works by this author on: Oxford Academic Google Scholar R.K. WINKELMANN R.K. WINKELMANN Mayo Clinic and Mayo Foundation, Rochester, Minnesota Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 97, Issue 5, 1 May 1977, Pages 481–486, https://doi.org/10.1111/j.1365-2133.1977.tb14123.x Published: 01 May 1977
Techniques in Therapeutic Endoscopy.
Authors: Jerome D. Waye
Journal: Annals of Internal Medicine (1987)

Presents therapeutic applications of the endoscope for gastrointestinal disorders. The authors are among the world's leading practioners of the techniques described, from laser treatment to polypectomy to sphincterotomy. Clear, full-color schematics and endoscopic views take the reader step-by-step through gastrointestinal bleeding, esophageal variceal sclerotherapy, esophageal and other GI cancers, percutaneous endoscopic gastrostomy, and more.
Early Perforation in Appendicitis After Age 60
Authors: Arnold G. Coran
Journal: JAMA (1966)

Twenty-eight consecutive cases of acute appendicitis have been reviewed in patients 60 to 91 years of age. The clinical picture was usually similar but less striking than that seen in young adults. The appendix had perforated in 17 of 21 patients operated upon more than 24 hours after onset of symptoms, but in only one of six patients operated upon before this time. Perforation was frequently correlated with septic complications and was felt to be the chief cause of mortality (2/28, 7%) and complication rate (11/28, 41%). Because of the high incidence of early perforation with acute appendicitis in the elderly, prompt surgical exploration is even more urgent than in younger patients.
Transcription of Il17 and Il17f Is Controlled by Conserved Noncoding Sequence 2
Authors: Xiaohu Wang, Yibing Zhang, Xuexian O. Yang, Roza I. Nurieva, Seon Hee Chang, Sandra S. Ojeda, Hong S. Kang, Kimberly S. Schluns, Jianfang Gui, Anton M. Jetten, Chen Dong
Journal: Immunity (2012)
p53 Expression as a Prognostic Marker in Inflammatory Breast Cancer
Authors: Ana M. Gonzalez-Angulo, Nour Sneige, Aman U. Buzdar, Vicente Valero, Shu-Wan Kau, Kristine Broglio, Yuko Yamamura, Gabriel N. Hortobagyi, Massimo Cristofanilli
Journal: Clinical Cancer Research (2004)

Abstract Purpose: Inflammatory breast cancer (IBC) is a rare and aggressive form of breast cancer. Nuclear expression of p53 protein in breast cancer correlates with more aggressive tumors. We retrospectively analyze the expression of p53 as a prognostic marker to predict pathological complete response and survival in patients with IBC. Experimental Design: Fifty-nine patients with IBC were treated from January 1994 to April 2000. Forty-eight patients were included. Diagnostic core biopsies were taken before treatment was started. Expression of hormone receptors and p53 was determined by immunohistochemistry. All patients received an anthracycline-based regimen preoperatively; 22 patients (46%) also received paclitaxel. Forty-four patients (92%) achieved an objective clinical response and underwent mastectomies. Results: Median age at diagnosis was 48 years. Thirty patients (63%) had hormone receptor-negative tumors. Twenty-eight patients (58%) had p53-positive tumors, and 20 patients (42%) had p53-negative tumors. Nine patients (19%) achieved a pathological complete response. At a median follow-up of 77 months, 28 recurrences (58%) and 26 deaths (54%) had occurred. Patients with p53-positive tumors were younger (P = 0.02) and tended to have lower 5-year progression-free survival rates (35% versus 55%; P = 0.3) and overall survival rates (44% versus 54%; P = 0.4). Conclusions: This retrospective analysis demonstrates that nuclear p53 protein expression may represent an adverse prognostic marker in IBC and may provide a valuable tool for selecting treatment for this aggressive disease.
ACUTE HAEMOLYTIC ANAEMIA IN ADOLESCENCE
Authors: A. Douglas
Journal: BMJ (1933)

MEDICAL jounN,AL apparently extending to the apex of the space.Dilatation of the superficial veins was present in the brachial and pectoral regions and antero-lateral chest wall.At no period was there any pain or tenderness, and the brachial and radial pulses were normal.A full blood count, including an estimation of the platelets, revealed no abnormality.The Wassermann reaction was negative, and an x-ray of the chest and the root of the neck showed no unusual feature.He was treated by rest, elevation, and later by massage.During the weeks that followed, the dilatation of the superficial veins steadily
Involvement of integrin-linked kinase in carbon tetrachloride–induced hepatic fibrosis in rats
Authors: Yining Zhang, Tadashi Ikegami, Akira Honda, Teruo Miyazaki, Bernard Bouscarel, Marcos Rojkind, Ichinosuke Hyodo, Yasushi Matsuzaki
Journal: Hepatology (2006)

Integrin-linked kinase (ILK) is a multidomain focal adhesion protein implicated in signal transduction between integrins and growth factor receptors. Although its expression is upregulated in pulmonary and renal fibrosis, its role in the development of hepatic fibrosis remains to be determined. Therefore, we considered it important to investigate whether ILK is involved in activation of hepatic stellate cells and thus plays a role in the development of hepatic fibrosis. Immunohistochemical analysis of liver sections obtained from rats with CCl4-induced cirrhosis revealed increased expression and colocalization of ILK and alpha-smooth muscle actin in hepatic stellate cells in perisinusoidal areas. In addition, hepatic stellate cells isolated from fibrotic livers expressed high levels of ILK and alpha-smooth muscle actin, and their expression was sustained in culture. In contrast, hepatic stellate cells (HSCs) isolated from normal rat liver did not express ILK, but its expression was increased when the cells were activated in culture. Our studies also showed that ILK is involved in the phosphorylation of ERK 1/2, p38 MAPK, JNK, and PKB and that selective inhibition of ILK expression by siRNA results in a significant decrease in their phosphorylation. These changes were accompanied by significant inhibition of cell spreading and migration without affecting cell proliferation. In conclusion, ILK plays a key role in HSC activation and could be a possible target for antifibrogenic therapy.
Inspired by migraine
Authors: E H Jellinek
Journal: Journal of the Royal Society of Medicine (2002)

I enjoyed the article on the influence of migraine upon art (August 2002 JRSM1). Some years ago I wrote some poems while in the grip of recurrent severe migraine—fortunately now much improved. Here is one of them, which I called Pain Pie:


Boil the pain. Bake it. Make it into bread.

Pain d'epice, spice of life, why am I dead?

Draw the pain. Paint it. Pull it from my head.

Art is life. Life is art. Live it, she said.
Confused Drug Names
Authors: RICHARD L. WITTAKER
Journal: Annals of Internal Medicine (1980)

Letters and Corrections1 December 1980Confused Drug NamesRICHARD L. WITTAKER, M.D.RICHARD L. WITTAKER, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-93-6-933_2 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: I am writing in response to the brief case report (1) on the inadvertant ingestion of tolazamide that produced a pseudoinsulinoma syndrome. The authors' point on "the value of carefully identifying patient's home medications" is well made.I am reminded of an elderly woman whom I saw in consultation several years ago for unexplained purpura. A very high prothrombin time was found without apparent cause. She was reported to have been taking procyclidine hydrochloride (Kemadrin; Burroughs Wellcome Co., Research Triangle Park, North Carolina), 5 mg three times daily. When the prescription was obtained and accurately identified, it...Reference1. AHLQUISTNELSONCALLAWAY DRC. Pseudoinsulinoma syndrome from inadvertant tolazamide ingestion. Ann Intern Med. 1980;93:281-2. LinkGoogle Scholar1. AHLQUISTNELSONCALLAWAY DRC. Pseudoinsulinoma syndrome from inadvertent tolazamide ingestion. Ann Intern Med. 1980;93:281-2. LinkGoogle Scholar1. AHLQUISTNELSONCALLAWAY DRC. Pseudoinsulinoma syndrome from inadvertent tolazamide ingestion. Ann Intern Med. 1980;93:281-2. LinkGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: University of Tennessee College of Medicine Knoxville, TN 37920 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByMedication errors resulting from the confusion of drug namesInadvertent Dispensing of Oral Hypoglycemic DrugsDiabinese® and Dialume®DAVID J. COHEN, M.D., MARTIN SALTZMAN, M.D., GERALD B. APPEL, M.D. 1 December 1980Volume 93, Issue 6Page: 933-934KeywordsDrugsElderlyIngestionProthrombin time Issue Published: 1 December 1980 PDF DownloadLoading ...
Emergency recall fees and basic salary increase
Authors: N F Harley, P W Brighten, J P Partridge, J M McGarry, S J Forster, D I Stirk, J R Barker, A M Dawson
Journal: BMJ (1979)

<h3>Background</h3> The role of tumor-associated macrophages (TAMs) in determining the outcome between the antitumor effects of the adaptive immune system and the tumor’s anti-immunity stratagems, is controversial. Macrophages modulate their activities and phenotypes by integration of signals in the tumor microenvironment. Depending on how macrophages are activated, they may adopt so-called M1-like, antitumor or M2-like, protumor profiles. In many solid tumors, a dominance of M2-like macrophages is associated with poor outcomes but in some tumor types, strong M1-like profiles are linked to better outcomes. We aimed to investigate the interrelationship of these TAM populations to establish how they modulate the efficacy of the adaptive immune system in early lung cancer. <h3>Methods</h3> Macrophages from matched lung (non-tumor-associated macrophages (NTAMs)) and tumor samples (TAMs) from resected lung cancers were assessed by bulk and single-cell transcriptomic analysis. Protein expression of genes characteristic of M1-like (chemokine (C-X-C motif) ligand 9) or M2-like (matrix metallopeptidase 12) functions was confirmed by confocal microscopy. Immunohistochemistry related the distribution of TAM transcriptomic signatures to density of CD8<sup>+</sup> tissue-resident memory T cells (T<sub>RM</sub>) in tumors and survival data from an independent cohort of 393 patients with lung cancer. <h3>Results</h3> TAMs have significantly different transcriptomic profiles from NTAMs with &gt;1000 differentially expressed genes. TAMs displayed a strong M2-like signature with no significant variation between patients. However, single-cell RNA-sequencing supported by immuno-stained cells revealed that additionally, in 25% of patients the M2-like TAMs also co-expressed a strong/hot M1-like signature (M1<sup>hot</sup>). Importantly, there was a strong association between the density of M1<sup>hot</sup> TAMs and T<sub>RM</sub> cells in tumors that was in turn linked to better survival. Our data suggest a mechanism by which M1<sup>hot</sup> TAMs may recruit T<sub>RM</sub> cells via CXCL9 expression and sustain them by making available more of the essential fatty acids on which T<sub>RM</sub> depend. <h3>Conclusions</h3> We showed that in early lung cancer, expression of M1-like and M2-like gene signatures are not mutually exclusive since the same TAMs can simultaneously display both gene-expression profiles. The presence of M1<sup>hot</sup> TAMs was associated with a strong T<sub>RM</sub> tumor-infiltrate and better outcomes. Thus, therapeutic approaches to re-program TAMs to an M1<sup>hot</sup> phenotype are likely to augment the adaptive antitumor responses.
SKIN REACTIONS WITH GONOCOCCUS FILTRATES (TOXIN?)
Authors: RUSSELL D. HERROLD
Journal: JAMA (1925)

It has been generally held that the toxicity of the gonococcus is due to the so-called endotoxins that are set free only after the death of the organism. De Christmas 1 reported that he was able to obtain a true exotoxin in cultures by growing the gonococcus in serum broth medium. The filtrate obtained by passing the culture through talc was toxic to guinea-pigs, mice and rabbits, and when diluted 1: 10 and held in the anterior human urethra, a definite temporary urethritis and discharge occurred. He stated also that this toxin was destroyed by heating at from 75 to 80 C. He believed it to be an exotoxin, because it could be detected in the broth cultures within twenty-four hours. Other workers report that they have obtained, from autolysed extracts of the gonococcus, a toxic substance that answers all the requirements of De Christmas' toxin; and they have attributed
1088-131 Effects of acupuncture compared with placebo-acupuncture on autonomic function, exercise tolerance, and quality of life in patients with heart failure: A randomized controlled single-blind pilot study
Authors: Johannes Backs, Antonius Schneider, Kathrin Strych, Boris Schuhmacher, Arnt V Kristen, Dirk Lossnitzer, Robert Kell, Armin Haunstetter, Hans-Christoph Friederich, Konrad Streitberger, Markus Haass
Journal: Journal of the American College of Cardiology (2004)
The abolition of memory
Authors: T. Dalrymple
Journal: BMJ (2009)

The ambition to understand the workings of the brain, the better to control thoughts and emotions, is an old one—as is the claim that such understanding is just around the corner. In 1880 the American socialist Edward Bellamy (1850-98), best known for his utopian novel Looking Backward , implied this claim in his novel Dr Heidenhoff’s Process .

Dr Heidenhoff practises in Boston but has a slight German accent that reassures his patients of his intelligence and scientific prowess. The process he has discovered is one by means of which he is able to eradicate guilty memories, thus turning a sinner back into an innocent: “Given a patient, who, by excessive indulgence of any particular train …
DNA oligonucleotide microarray technology identifies fisp-12 among other potential fibrogenic genes following murine unilateral ureteral obstruction (UUO): Modulation during epithelial-mesenchymal transition
Authors: Debra F. Higgins, David W.P. Lappin, Niamh E. Kieran, Hans J. Anders, Ronald W.G. Watson, Frank Strutz, Detlef Schlondorff, Volker H. Haase, John M. Fitzpatrick, Catherine Godson, Hugh R. Brady
Journal: Kidney International (2003)
Physiology of Membrane Disorders
Authors: Eugene D. Robin
Journal: JAMA (1979)

This multiauthored book is large in size and vast in scope. It is divided into five parts, the final section being devoted to clinical disorders of membrane transport. The general level of scholarship is high. In common with other large multiauthored volumes, the quality and usefulness vary extensively from chapter to chapter (and from reader to reader). Particularly well-written chapters include chapter 5 (Sachs and Kinne) on isolation and characterization of biological membranes, chapter 9 (Andreoli and Schafer) on principles of water and nonelectrolyte transport across membranes, chapter 14 (Dunham and Hoffman) on sodium and potassium transport in RBCs, chapter 18 (Loewenstein) on cell-to-cell communication (superb), chapter 21 (Fanestil) on receptors, and chapter 51 (Leaf and Macknight) on ischemia and disturbances in cell volume. Each chapter is well referenced, which provides a most valuable resource in specialized fields. This is an excellent book, but there are problems. At most, the
AGRANULOCYTOSIS WITH PURPURA HAEMORRHAGICA FOLLOWING GOLD THERAPY: WITH A NOTE ON PREVENTION OF COMPLICATIONS
Authors: P. Ellman, J. S. Lawrence
Journal: BMJ (1935)

more accurate observations on this type of case.In the case of multiple secondary cysts, too, the surgeon is often faced with an apparently insoluble problem, and it is possible that we may have to wait for the discovery of some method of general intravenous therapy before we achieve complete success in their management. ConclusionIn conclusion, I would urge that, although we have learnt a great deal about the disease, although we prob- ably know as much about its behaviour, its clinical mani- festations, and its treatment as any other disease we meet with, it would be wrong for us to become complacent and not to continue making observations and experimenting to still further elucidate problems which, although they may appear somewhat academic, may become in reality of great practical importance.In this country of Australia we all have unrivalled opportunities to investigate this disease, both in man and in animals, and it is our duty to contribute our share to future advances in, its study.
Articular Oxalate Crystals and the Taxonomy of Gout
Authors: Peter A. Simkin
Journal: JAMA (1988)

In this issue ofTHE JOURNAL, Rosenthal et al<sup>1</sup>report the case of an anephric, dialyzed patient experiencing acute arthritis associated with calcium oxalate crystals. Together with reports from Hoffman et al,<sup>2</sup>Schumacher et al,<sup>3</sup>and Reginato et al,<sup>4</sup>this observation establishes an unequivocal place for oxalate among the solutes that abnormally crystallize in and around human joints. As yet, these authors, who together with Paul Dieppe are the leading students of crystalinduced disease, have not settled on a simple name for this