tbuckley/cabot-search huggingface dataset:
Primary cutaneous lymphoma: two-decade comparison in a population of 263 cases from a Swiss tertiary referral centre
Authors: D. Jenni, M.B. Karpova, B. Seifert, Ph. Golling, A. Cozzio, W. Kempf, L.E. French, R. Dummer
Journal: British Journal of Dermatology (2010)

Journal Article Primary cutaneous lymphoma: two‐decade comparison in a population of 263 cases from a Swiss tertiary referral centre Get access D. Jenni, D. Jenni Department of Dermatology, University Hospital Zürich, Gloriastrasse 31, 8091 Zürich, Switzerland Search for other works by this author on: Oxford Academic Google Scholar M.B. Karpova, M.B. Karpova Department of Dermatology, University Hospital Zürich, Gloriastrasse 31, 8091 Zürich, Switzerland Search for other works by this author on: Oxford Academic Google Scholar B. Seifert, B. Seifert Biostatistics Unit, Institute for Social and Preventive Medicine, University of Zürich, Zürich, Switzerland Search for other works by this author on: Oxford Academic Google Scholar Ph. Golling, Ph. Golling Department of Dermatology, University Hospital Zürich, Gloriastrasse 31, 8091 Zürich, Switzerland Search for other works by this author on: Oxford Academic Google Scholar A. Cozzio, A. Cozzio Department of Dermatology, University Hospital Zürich, Gloriastrasse 31, 8091 Zürich, Switzerland Search for other works by this author on: Oxford Academic Google Scholar W. Kempf, W. Kempf Department of Dermatology, University Hospital Zürich, Gloriastrasse 31, 8091 Zürich, Switzerland Search for other works by this author on: Oxford Academic Google Scholar L.E. French, L.E. French Department of Dermatology, University Hospital Zürich, Gloriastrasse 31, 8091 Zürich, Switzerland Search for other works by this author on: Oxford Academic Google Scholar R. Dummer R. Dummer Department of Dermatology, University Hospital Zürich, Gloriastrasse 31, 8091 Zürich, Switzerland Reinhard Dummer. E‐mail: Reinhard.Dummer@usz.ch Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 164, Issue 5, 1 May 2011, Pages 1071–1077, https://doi.org/10.1111/j.1365-2133.2010.10143.x Published: 01 May 2011
Clorazepate and lorazepam: clinical improvement and rebound anxiety
Authors: K Rickels, I L Fox, D J Greenblatt, K R Sandler, A Schless
Journal: American Journal of Psychiatry (1988)

Sixty-two anxious patients were treated under double-blind conditions for 4 weeks with either clorazepate or lorazepam. Two-thirds of each treatment group were then switched abruptly to placebo for 2 weeks, while one-third continued to receive active medication. Two major findings were obtained. About 70% of the patients maintained improvement during the 2-week placebo period. Some patients, however, experienced rebound anxiety, which appeared to be more intense and occurred earlier when placebo was substituted for a benzodiazepine with a short half-life (lorazepam) than for one with a long half-life (clorazepate). The clinical relevance of these findings is discussed.
Hydrogels in endovascular embolization
Authors: Daniel Horák, František Švec, Jaroslav Kálal, Arnold Adamyan, Nikolai Skuba, Maria Titova, Vasilii Dan, Boris Varava, Nadezhda Trostenyuk, Olga Voronkova, Klara Gumargalieva, Valeriya Timochina
Journal: Biomaterials (1988)
Treatment of Respiratory Failure.
Authors: M E Nassar
Journal: Annals of Internal Medicine (1983)

case the biological end-point is retinal vessel occlusion, with consequent retinal ischaemia and neovascularization.The case for synergism cannot be made on the basis of the total dose prescribed.Equally, there is no evidence that I am aware of that radiation and hyperbaric oxygen are synergistic in their actions on endothelial cells.Oxygen is only considered to be a sensitizer of hypoxic cells.Unless this patient had pre-existing retinal ischaemia, it would be difficult to argue that oxygen acted as a radiation sensitizer, there being no current evidence of hypoxic cells in healthy retina.
Neurological Complications of Oral Contraceptives.
Authors: Edwin R Bickerstaff
Journal: Annals of Internal Medicine (1975)

This publication provides an excellent oppor- tunity for keeping up to date with the growing points of gastroenterology, particularly those which are of special interest and concern to the clinician.The book has been published in record time, following the course held in Oxford in January this year.It is a book which is equally important for senior gastroenterologists as it is for those who are starting to work in this field.P. R. Salmon discusses the scope of present- day gastrointestinal endoscopy.Denis Gibbs surveys the normal appearances in upper gastrointestinal endoscopy-of particular in- terest to the younger endoscopists-and K. F. R. Schiller reviews the diagnostic applications.The endoscopist, the histo- pathologist, the cytologist come together in the chapter by Martin Roca, R. Whitehead, and M. M. Boddington to review tissue diagnosis.P. B. Cotton is the obvious choice
347. Pharmacological Regulation of Dendritic Cell Activation: Enhancing Cancer Vaccine Efficacy
Authors: Brent A. Hanks, Jianghong Jiang, David M. Spencer
Journal: Molecular Therapy (2004)

Introduction:Dendritic cells (DCs) play a critical role in initiating and directing T cell immune responses. The unique DC molecular repertoire allows this antigen-presenting cell to stimulate naive T cell activation and overcome self-antigen tolerance, making DCs an attractive natural adjuvant for tumor vaccine development. The CD40 surface molecule is utilized by CD4+ T helper cells to deliver a potent activation signal that empowers DCs to prime cytotoxic T lymphocytes (CTLs).
Abstract 11867: Late Stroke Rates After Maze Procedure
Authors: Hiroshi Tsuneyoshi, Tatsuhiko Komiya, Takeshi Shimamoto
Journal: Circulation (2014)

Introduction: Late stroke can affect quality of life after cardiac surgery. Atrial fibrillation is the most common cardiac arrhythmia and raises the risk of stroke; however, the incidence of late stroke after the Maze procedure has not been determined. Methods: We conducted a retrospective review of 4021 patients who underwent cardiac surgery at our institution between 2000 and 2013. Results: Follow-up data were obtained from 88% of patients at a mean of 4.8±3.4 years. Among these patients, 2.4% (95/4021) experienced symptomatic late stroke (mean period after surgery was 55±35 months, and the mean age was 72±13 years). About 32% (30/95) of patient strokes were caused from atrial fibrillation, 2% (2/95) from hemorrhagic events, 3% (3/95) from cerebral artery diseases, and 63% (60/95) from unknown causes. Among 345 of the 4021 patients who underwent the Maze procedure (Full Maze: 157, LA Maze: 132, PV isolation: 56), 70.5% have remained in sinus rhythm as of their last follow-up. Just 4.3% (15/345) of patients that underwent the Maze procedure had a late stroke during the follow-up period. Of the 15 patients who had a late stroke, 10 failed the Maze procedure and remained in atrial fibrillation. In 60% (9/15) of patients experiencing a late stroke after the Maze procedure, the LA appendage was not closed at the time of surgery. Conclusions: The cause of late stroke after cardiovascular surgery was atrial fibrillation in not less than 30% of patients. The incidence of late stroke after the Maze procedure was 4.3%, which was relatively low considering these patients had arrhythmia problems before the operation (2.4% of all cardiac patients experienced a late stroke). Unsuccessful cases of the Maze procedure and non-LA appendage closure were considered risk factors for late stroke. When patients have atrial fibrillation prior to surgery, we recommend a concomitant Maze procedure or at least LA appendage closure to reduce the incidence of late stroke.
Abstract 14679: Demographic and Epidemiologic Drivers of Cardiovascular Mortality: Findings from the Global Burden of Disease, Injuries and Risk Factors Study, 1990-2010
Authors: Gregory A Roth, Mohammad H Forouzanfar, Andrew Moran, Ryan M Barber, Grant Nguyen, Valery Feigin, Mohsen Naghavi, George Mensah, Christopher J Murray
Journal: Circulation (2014)

Introduction:  Global cardiovascular disease (CVD) deaths are increasing due to the combined effects of three factors: population growth, population ageing, and changes in disease epidemiology. Disentangling the impact of these three drivers on trends in mortality is important for health system planning and benchmarking progress towards the reduction in CVD. We hypothesized large regional variation in these demographic forces.   Methods:  We used all available CVD mortality data, as estimated for the Global Burden of Disease, Risk Factors,and Injuries Study 2010 (GBD 2010) in 187 countries. Three counterfactual scenarios were computed representing drivers of change in CVD deaths from 1990 to 2010 (population growth alone, growth and ageing, and change in disease epidemiology) in 21 world regions. We repeated our analysis 1000 times for each 5-year age-sex-country-specific death rate, separately for 10 sub-causes of CVD, using the complete set of model draws from GBD 2010 and report the mean and 95% uncertainty interval of the resulting distribution.   Results:  There was a 34.1% (95% UI 31.2-38.9) decrease in age-specific CVD death rates between 1990-2010 but the number of global deaths continued to rise. The increase was due to a 44.7% (95% UI 44.4-45.1) increase in CVD deaths due to population ageing and a 20.5% (95% UI 20.0-20.9) increase due to population growth. Population ageing and growth led to a significant increase in CVD deaths in most regions. Ageing and growth drove increases in deaths with smaller or no improvement in age-specific CVD mortality in S Asia, C Asia, SE Asia, E Asia, Oceania, and the Caribbean. Ageing alone drove the increase in E Europe. Improvements in health balanced ageing in the high income Asia Pacific. For Southern Latin America, C Europe, Australasia, high income N America, and W Europe, improvements in health led to stable or decreased deaths despite ageing and growth. Only atrial fibrillation and PVD, as sub-causes of CVD, saw increases in all three drivers of change.   Conclusions:  Population ageing and growth account for a large part of the increasing number of global deaths due to CVD. Only a few regions have experienced gains in cardiovascular health large enough to offset these demographic trends.
Comparison of antifungal MICs for yeasts obtained using the EU-CAST method in a reference laboratory and the Etest in nine different hospital laboratories
Authors: E. Dannaoui, A. Paugam, M. Develoux, C. Chochillon, J. Matheron, A. Datry, C. Bouges-Michel, C. Bonnal, F. Dromer, S. Bretagne
Journal: Clinical Microbiology and Infection (2009)
Abstract 878: Identification and characterization of tumor-associated antigens as biomarkers in human prostate cancer
Authors: Jitian Li, Liping Dai, Carlos A. Casiano, Jianying Zhang
Journal: Cancer Research (2014)

Abstract Autoantibodies against intracellular antigens are commonly found in a number of systemic autoimmune diseases. Their utility in providing insights into molecular and cellular biology and in the differential diagnosis of autoimmune diseases is well documented. Autoimmune phenomena manifested as antibodies to cellular components have been described in many types of cancer. Prostate cancer (PCa) is the most frequently diagnosed cancer in men and the second leading cause of male cancer deaths in the United States. PCa also presents the greatest racial disparity in this country, with an incidence and mortality in African-American men that is 3 times higher than in White and Latino men. Reducing these disparities would require a multi-faceted approach that includes developing more effective screening method for the early detection of PCa. The objective of this study is to analyze the frequency and specificity of autoantibodies in PCa patients, and further to identify and characterize the targeted tumor-associated antigens. In this study, 34 sera from PCa patients, and 30 sera from normal human individuals were examined for autoantibodies using indirect immunofluorescence (IIF) assay and western blotting. Autoantibodies were detected in 18 of 34 (52.9%) PCa sera by IIF, which was significantly higher than that in normal human sera. Of the interest is that of 34 PCa sera, 9 (26.5%) sera were identified by western blotting analysis containing antibodies against an unknown 70kDa cellular protein and 23.5% PCa patients showed antibody to 45 kDa protein. No reactivity with 70KDa and 45kDa proteins was detected in 30 normal human sera. In the further study, these cellular proteins targeted by serum antibodies in PCa were identified by using two-dimensional gel electrophoresis (2DE) and liquid chromatography-tandem-mass spectrometry (LC-MS/MS). This preliminary data supports that autoimmune responses to certain cellular proteins maybe a by-product in the transformation to PCa, and further studies of novel targeted proteins in PCa may provide insights into how these proteins might be involved in malignancy. Citation Format: Jitian Li, Liping Dai, Carlos A. Casiano, Jianying Zhang. Identification and characterization of tumor-associated antigens as biomarkers in human prostate cancer. [abstract]. In: Proceedings of the 105th Annual Meeting of the American Association for Cancer Research; 2014 Apr 5-9; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2014;74(19 Suppl):Abstract nr 878. doi:10.1158/1538-7445.AM2014-878
PRODUCTION OF ANAPHYLACTIC ANTIBODIES TO DRUGS IN EXPERIMENTAL ANIMALS
Authors: ATHANASIA LIAKOPOCLOU, L. PERELMUTTER
Journal: Allergy (1975)

Studies were undertaken to determine if animals exposed to benzylpenicillin could produce anaphylactic antibodies to the drug moiety. For this purpose, Albino Wistar rats were divided into four groups. Two groups of animals were immunized with benzylpenicillin using either the intraperitoneal or the subcutaneous route. The remaining two groups were used for feeding experiments. The animals were bled upon termination of the experiments; their sera were collected and pooled per group. The pooled sera were tested for the presence of anaphylactic antibodies. Histamine release from rat mast cells under the appropriate conditions was used as an indicator of antibody production. Penicilloylpolylysine and benzylpenicillin were both employed to determine antibody specificity. It was found that sera from all groups of animals contained anaphylactic antibodies with specificity towards the penicilloyl group and "benzylpenicillin".
A DIAGNOSTIC SIGN OF SPONTANEOUS INTERSTITIAL EMPHYSEMA OF THE MEDIASTINUM; CASE REPORTS
Authors: Robert J. Griffin
Journal: Annals of Internal Medicine (1942)

Article1 August 1942A DIAGNOSTIC SIGN OF SPONTANEOUS INTERSTITIAL EMPHYSEMA OF THE MEDIASTINUM; CASE REPORTSROBERT J. GRIFFIN, M.D.ROBERT J. GRIFFIN, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-17-2-295 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptIn our experience with the male student body at the University of Kentucky, the incidence of spontaneous (idiopathic) pneumothorax is about one case per year per 1000 male students.1In one of the cases previously reported, a "popping" or "crunching" sound was heard over the precordium which was audible to the patient. Of four cases of spontaneous pneumothorax observed by the author since this paper was written, three presented this phenomenon. Hamman2has observed this sign and feels that it is pathognomonic of mediastinal emphysema, a step in the occurrence of spontaneous pneumothorax. So few simple physical signs are absolutely...Bibliography1. GRIFFIN RJ: Spontaneous pneumothorax, Kentucky Med. Jr., 1941, xxxix, 284-288. Google Scholar2. HAMMAN L: Spontaneous mediastinal emphysema, Bull. Johns Hopkins Hosp., 1939, lxiv, 1. Google Scholar3. MACKLIN CC: Pneumothorax with massive collapse from experimental local over inflation of the lung substance, Canad. Med. Assoc. Jr., 1937, xxxvi, 414-420. Google Scholar4. MACKLIN CC: Transport of air along sheaths of pulmonic blood vessels from alveoli to mediastinum, Arch. Int. Med., 1939, lxiv, 913-926. CrossrefGoogle Scholar5. WOLFE BP: Spontaneous interstitial emphysema of the lungs, ANN. INT. MED., 1940, xiii, 1250-1252. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Lexington, Kentucky*Received for publication July 22, 1941. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byMediastinumACUTE SPONTANEOUS MEDIASTINAL EMPHYSEMAMEDIASTINAL EMPHYSEMA OCCURRING WITH THERAPEUTIC PNEUMOPERITONEUM: REPORT OF TEN CASES*MILTON N. TOWBIN, M.D.Acute pulmonary interstitial and mediastinal emphysema (airblock) and pneumothorax in infancy and early childhoodSPONTANEOUS COLLAPSEThe phonocardiogram in spontaneous interstitial emphysema of the mediastinum 1 August 1942Volume 17, Issue 2Page: 295-297KeywordsEmphysema ePublished: 1 December 2008 Issue Published: 1 August 1942 PDF downloadLoading ...
Combination of Local Irradiation with Systemic Application of Anaerobic Corynebacteria in Therapy of a Murine Fibrosarcoma
Authors: Luka Milas, Nancy Hunter, H. Rodney Withers
Journal: Cancer Research (1975)

Summary  We studied whether local irradiation of a syngeneic fibrosarcoma in C3Hf/Bu mice could be made more effective by treating the tumor hosts with  Corynebacterium granulosum  or  Corynebacterium parvum . Tumors were generated by transplanting fibrosarcoma cells into muscles of the right thighs or into the skin in the right flank of mice. When the tumors in the thighs grew to 8 mm in diameter, they were irradiated with 2500 or 3500 rads of γ-rays.  C. granulosum  (0.5 mg i.p.) was injected into the mice 3 to 4 days before irradiation or at 3 hr or 2, 7, or 14 days after irradiation. Irradiation alone with 2500 rads induced permanent regression of only 18% of tumors.  C. granulosum  increased curability to between 27 and 50%, depending upon the time of treatment with the bacterium. The treatment with  C. granulosum  did not change the effectiveness of 3500 rads: 80% cures compared with 82% in mice that received local irradiation. Doses of 0.5 mg and 0.25 mg  C. granulosum  given i.p. and i.v., respectively, and 0.25 mg of  C. parvum  given i.v. about 3 hr after local irradiation reduced the dose of irradiation yielding local tumor control in 50% of animals which was 3400 rads in control mice by about 1000 rads.  Fibrosarcomas growing in the skin were irradiated with 2200 rads when 6 mm in diameter.  C. granulosum  (0.25 mg i.v.) was given about 3 hr after irradiation. Irradiation induced 25% permanent cures,  C. granulosum  gave 77% permanent cures and the combination of the 2 cured all treated mice.  Animals in which tumors were not controlled locally were less likely to develop pulmonary metastases if they had received adjuvant immunotherapy; only 4% of mice with local recurrence after irradiation alone were free of pulmonary metastases compared with 19% of those animals treated with irradiation and anaerobic corynebacteria.
Erratum to “Transduction patterns of pseudotyped lentiviral vectors in the nervous system” [Molecular Therapy 9: 101–111, doi: 10.1016/j.mthe.2003.09.017]
Authors: Liang-Fong Wong, Mimoun Azzouz, Lucy E Walmsley, Zoe Askham, Fraser J Wilkes, Kyriacos A Mitrophanous, Susan M Kingsman, Nicholas D Mazarakis
Journal: Molecular Therapy (2004)

The publisher regrets that a proof correction requested by the author was misinterpreted. On page 109, left-hand column, lines 15 and 16 should read: "In differentiated PC12 cells, p75NTR has been shown to internalize into vesicles bound to its ligand NGF [30]." Transduction Patterns of Pseudotyped Lentiviral Vectors in the Nervous SystemWong et al.Molecular TherapyJanuary, 2004In BriefWe have developed a non-primate-based lentiviral vector based on the equine infectious anemia virus (EIAV) for efficient gene transfer to the central and peripheral nervous systems. Previously we have demonstrated that pseudotyping lentiviral vectors with the rabies virus glycoprotein confers retrograde axonal transport to these vectors. In the present study we have successfully produced high-titer EIAV vectors pseudotyped with envelope glycoproteins from Rhabdovirus vesicular stomatitis virus (VSV) serotypes (Indiana and Chandipura strains); rabies virus [various Evelyn–Rokitnicki–Abelseth ERA strains and challenge virus standard (CVS)]; Lyssavirus Mokola virus, a rabies-related virus; and Arenavirus lymphocytic choriomeningitis virus (LCMV). Full-Text PDF Open Archive
ACC/AHA clinical competence statement on echocardiography11When citing this document, the American College of Cardiology, the American Heart Association, and the American College of Physicians–American Society of Internal Medicine would appreciate the following citation format: Quiñones MA, Douglas PS, Foster E, Gorcsan J, Lewis JF, Pearlman AS, Rychik J, Salcedo EE, Seward J, Stevenson JG, Thys DM, Weitz HH, and Zoghbi WA. ACC/AHA clinical competence statement on echocardiography: a report of …
Authors: Miguel A Quiñones, Pamela S Douglas, Elyse Foster, John Gorcsan, Jannet F Lewis, Alan S Pearlman, Jack Rychik, Ernesto E Salcedo, James B Seward, J.Geoffrey Stevenson, Daniel M Thys, Howard H Weitz, William A Zoghbi, Mark A Creager, William L Winters, Michael Elnicki, John W Hirshfeld, Beverly H Lorell, George P Rodgers, Cynthia M Tracy, Howard H Weitz
Journal: Journal of the American College of Cardiology (2003)
Abstract 19288: Pulmonary Hypertension and Sex Hormone Depletion Affect Lung and Right Ventricular Estrogen Receptor Expression
Authors: Andrea Frump, Amanda Fisher, Anthony Cucci, Marjorie Albrecht, Kara Goss, Roziya Tursunova, Jordan Whitson, Mary Van Demark, Robert Presson, Irina Petrache, Mary Beth Brown, Tim Lahm
Journal: Circulation (2014)

Introduction: Women with pulmonary arterial hypertension exhibit more preserved right ventricular (RV) function than men. The underlying mechanisms are unknown. We measured 17beta-estradiol (E2) levels and lung and RV expression of the two main estrogen receptors (ERalpha and -beta) in male and in intact or ovariectomized (OVX) female rats with Su5416/hypoxia (SuHx)-induced pulmonary hypertension (PH). Hypothesis: E2 is required for adaptation to increased RV afterload in females, and ER expression is inversely correlated with PH severity. Methods: Male and age-matched female Sprague-Dawley rats received Su5416 (20mg/kg), followed by 3 weeks of hypoxia (Patm=362 mmHg) and 4 weeks of room air. Selected females underwent OVX with or without concomitant E2 repletion (75 mcg/kg/d). RV hypertrophy (RV/[LV+S]), RV systolic pressure (RVSP), and PA muscularization were measured; complemented by echocardiographic assessment of RV function and measurement of exercise capacity (VO2max). In addition, we assessed RV pro-apoptotic signaling (bcl-2/bax; caspase-3 activity), serum E2 levels, and lung and RV ER expression by Western blot. N was 7-8/group. P&lt;0.05 was considered significant. Results: While no sex differences were noted in RV/(LV+S), RVSP or PA remodeling, female SuHx rats exhibited more preserved cardiac indices (CI; p&lt;0.05). OVX worsened SuHx-induced alterations in RV hypertrophy, RVSP and CI (p&lt;0.05). In turn, E2 replacement in SuHx-OVX rats prevented SuHx-induced alterations in PH endpoints and RV function; this was accompanied by attenuated RV pro-apoptotic signaling. RV ERbeta decreased in OVX SuHx females, but was restored with E2 repletion (p&lt;0.05). RV ERbeta correlated negatively with RVSP and RV/(LV+S), and positively with RV bcl-2/bax (p&lt;0.05). Similarly, serum E2 levels correlated negatively with RVSP and RV/(LV+S) (p&lt;0.05). While healthy females exhibited higher lung ERbeta than healthy males (p&lt;0.05), no such differences were observed in SuHx-PH. Neither lung nor RV ERalpha was affected by PH or hormone depletion. Conclusions: E2 is required for female adaption to SuHx-PH, through a mechanism that may involve ERbeta-mediated RV cell viability signaling, thus allowing for better adaptation to increases in RV afterload.