EVALUATION OF A CHOLESTEROL-SYNTHESIS INHIBITOR (TRIPARANOL)
Authors: M J CARVER, J G FREEMAN, J A SMITH
Journal: Annals of Internal Medicine (1960)

Article1 September 1960EVALUATION OF A CHOLESTEROL-SYNTHESIS INHIBITOR (TRIPARANOL)MICHAEL J. CARVER, Ph.D., JOHN G. FREEMAN, M.D., JACKSON A. SMITH, M.D., F.A.C.P.MICHAEL J. CARVER, Ph.D.Search for more papers by this author, JOHN G. FREEMAN, M.D.Search for more papers by this author, JACKSON A. SMITH, M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-53-3-462 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe role of cholesterol in the etiology and pathogenesis of atherosclerosis is not clearly understood; nevertheless, an association between hypercholesterolemia and atherosclerosis most probably exists, and has prompted continual study of methods of decreasing the level of serum cholesterol.The findings of Blohm et al. that Triparanol§produced a cholesterol-lowering effect on rats, and that the effect was the result of an inhibition of cholesterol biosynthesis, were met with interest by investigators. It was further established by Blohm et al. that the inhibition noted was specific for cholesterol.2Avigan et al.1indicate that the principal site of action of Triparanol...Bibliography1. AviganSteinbergThompsonMosettig JDMJE: Mechanism of action of MER-29, an inhibitor of cholesterol biosynthesis, Biochem. and Biophys. Research Communications 2: 63, 1960. CrossrefMedlineGoogle Scholar2. BlohmKariyaLaughlin TRTMW: Effects of MER-29, a cholesterol synthesis inhibitor, on mammalian tissue lipides, Arch. Biochem. and Biophys. 85: 250, 1959. CrossrefMedlineGoogle Scholar3. OaksLisan WP: A new cholesterol synthesis inhibitor, Federation Proc. 18: 428, 1959. Google Scholar4. OaksLisanMoyer WPJ: Inhibition of cholesterol synthesis with the use of MER-29, Arch. Int. Med. 104: 527, 1959. CrossrefMedlineGoogle Scholar5. RivinYoshinoShickmanSchjeide AUJMOA: Serum cholesterol measurement-hazards in clinical interpretation, J. A. M. A. 166: 2108, 1958. CrossrefMedlineGoogle Scholar6. WatkinLawryMannHalperin DMEYGVM: Study of serum beta lipoprotein and total cholesterol variability and its relation to age and serum level in adult human subjects, J. Clin. Investigation 33: 874, 1954. CrossrefMedlineGoogle Scholar7. ZakDickermanWhiteBurnettCherney BRCEGHPJ: Rapid estimation of free and total cholesterol, Am. J. Clin. Path. 24: 1307, 1954. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: *Received for publication May 13, 1960.†From the Nebraska Psychiatric Institute and the University of Nebraska College of Medicine, Omaha, Nebraska.‡Formerly of Nebraska Psychiatric Institute; now of Illinois State Psychiatric Institute, Chicago, Illinois.§1-[p-(β-diethylaminoethoxy)-phenyl]-1-(p-tolyl)-2-(p-chlorophenyl) ethanol. Triparanol used in this study was supplied as MER-29 by Wm. S. Merrell Company.This study was supported in part by the Nebraska Fund for Psychiatric Research and in part by a research grant (MY-2784) from National Institute of Mental Health, Public Health Service.Requests for reprints should be addressed to Michael J. Carver, M.D., Nebraska Psychiatric Institute, The University of Nebraska College of Medicine, 602 South Forty-fourth Avenue, Omaha 5, Nebraska. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byHepatitis C Virus Selectively Alters the Intracellular Localization of DesmosterolApproaches to the Treatment of HypercholesteremiaSTANLEY S. BERGEN JR., M.D., THEODORE B. VAN ITALLIE, M.D., F.A.C.P.TRIPARANOL AND NICOTINIC ACID IN THE MANAGEMENT OF HYPERCHOLESTEROLAEMIAChemotherapeutic Approaches to the Problem of Hyperlipidemia 1 September 1960Volume 53, Issue 3Page: 462-467KeywordsAtherosclerosisBiosynthesisCholesterolEthanolEtiologyMedical servicesPathogenesisPsychiatry and mental healthResearch fundingResearch grants ePublished: 1 December 2008 Issue Published: 1 September 1960 PDF downloadLoading ...