FATAL "WATERHOUSE-FRIDERICHSEN SYNDROME" DUE TO DICUMAROL
Authors: R G FRAGGE, I L BERNSTEIN, J BELL
Journal: Annals of Internal Medicine (1960)

Case Reports1 April 1960FATAL "WATERHOUSE-FRIDERICHSEN SYNDROME" DUE TO DICUMAROLRONALD G. FRAGGE, M.D., I. LEONARD BERNSTEIN, M.D., JAMES BELL, M.D.RONALD G. FRAGGE, M.D.Search for more papers by this author, I. LEONARD BERNSTEIN, M.D.Search for more papers by this author, JAMES BELL, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-52-4-923 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptBilateral adrenal hemorrhage incident to anticoagulant therapy is a rare occurrence. Only four cases have been documented in the literature since 1952. Three of these patients had received heparin, and one patient had been maintained on Dicumarol prior to death.1, 2, 3 In the Dicumarol-treated patient, emboli and infarctions were discovered in various organs; therefore, adrenal infarction could not be taken conclusively as the primary cause of the hemorrhage.3 Our case is presented because of the definite association of adrenal hemorrhage with anticoagulant therapy and the absence of any embolic phenomena at the postmortem examination.CASE REPORTA 69 year...Bibliography1. MerzAufdermaur WRA: Suprarenal apoplexy on heparin administration, Schweiz. med. Wchnschr. 82: 590, 1952. Google Scholar2. ThornGoldfienNelson GWADH: The treatment of adrenal dysfunction, M. Clin. North America 40: 1270, 1956. CrossrefGoogle Scholar3. Chokas WV: Bilateral adrenal hemorrhage complicating Dicumarol therapy for myocardial infarction, Am. J. Med. 24: 454-459, 1958. CrossrefMedlineGoogle Scholar4. Berte SJ: Spontaneous adrenal hemorrhage in the adult: literature review and report of two cases, Ann. Int. Med. 38: 28-37, 1953. LinkGoogle Scholar5. GoodmanGilman LSA: Pharmacological basis of therapeutics, 1955, The Macmillan Company, New York, pp. 1511-1514. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Cincinnati, Ohio*Received for publication October 13, 1958.From the Department of Internal Medicine, Jewish Hospital, Cincinnati, Ohio.Requests for reprints should be addressed to Ronald G. Fragge, M.D., Bellevue Hospital Center, First Avenue and Twenty-seventh Street, New York 16, N. Y. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byBilateral massive adrenal hemorrhageAddison’s DiseaseDiagnosis and treatment of anticoagulant-related adrenal hemorrhageOrale AntikoagulantienAdrenal Hemorrhage During Anticoagulant Therapy A Clinical and Pathological Study of Ten CasesELIAS AMADOR, M.D.Surgical complications of Dicumarol therapyANTICOAGULANTS-AN EMPIRICAL EVALUATION*Bilateral adrenal hemorrhage—A complication of anticoagulant therapyCase 11-1962Obstructive Uropathy Complicating Anticoagulant TherapyCURRENT VIEWS ON BLOOD COAGULATION AND HAEMORRHAGIC DISORDERSMassive Intraperitoneal Hemorrhage from a Ruptured Corpus Luteum 1 April 1960Volume 52, Issue 4Page: 923-929KeywordsAnticoagulant therapyAutopsyClinical laboratoriesHemorrhageHeparinHospital medicineInfarction ePublished: 1 December 2008 Issue Published: 1 April 1960 PDF downloadLoading ...