PRIMARY ALDOSTERONISM, A NEW CLINICAL ENTITY
Authors: J W CONN, L H LOUIS
Journal: Annals of Internal Medicine (1956)

Article1 January 1956PRIMARY ALDOSTERONISM, A NEW CLINICAL ENTITYJEROME W. CONN, M.D., F.A.C.P., LAWRENCE H. LOUIS, SCD.JEROME W. CONN, M.D., F.A.C.P., LAWRENCE H. LOUIS, SCD.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-44-1-1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptAldosterone, the newly discovered normal adrenal secretory product,1-6has attracted the attention of a great many clinical investigators because of its apparent rôle in the pathogenesis of a number of clinical disorders. This extremely potent sodium-retaining corticoid has been found to be present in excessive amounts in the urine of edematous nephrotics,7, 8cardiacs with congestive failure,9, 10patients with decompensated hepatic cirrhosis11-13and women with eclampsia.14-16All of these conditions manifest marked edema, but it is obvious that theprimarydifficulty in each condition isnotdue to increased activity of a sodium-retaining steroid. It seems reasonable to assume...Bibliography1. SimpsonTaitWettsteinNeherVon EuwReichstein SAJFARJT: Isolierung eines neuen kristallisierten Hormons aus Nebennieren mit besonders hoher Wirksamkeit auf den Mineralstoffwechsel, Experientia 9: 333, 1953. CrossrefMedlineGoogle Scholar2. SimpsonTaitWettsteinNeherVon EuwSchindlerReichstein SAJFARJOT: Konstitution des Aldosterons, des neuen Mineralocorticoid, Experientia 10: 132, 1954. CrossrefMedlineGoogle Scholar3. SimpsonTaitWettsteinNeherVon EuwSchindlerReichstein SAJFARJOT: Aldosteron, Isolierung und Eigenschaften. 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ConnLouis JWLH: Production of endogenous salt-active corticoids as reflected in the concentrations of sodium and chloride of thermal sweat, J. Clin. Endocrinol. 10: 12, 1950. CrossrefGoogle Scholar34. SimpsonTait SAJF: Some recent advances in methods of isolation and the physiology and chemistry of electrocortin, Recent Progress in Hormone Research, in press. Google Scholar35. Schwartz WB: Potassium and the kidney, in press. Google Scholar36. EvansMilne BMMD: Potassium-losing nephritis presenting as a case of periodic paralysis, Brit. M. J. 2: 1067, 1954. CrossrefMedlineGoogle Scholar37. CopeGardcia-Llaurado CLJ: The occurrence of electrocortin in human urine, Brit. M. J. 1: 1290, 1954. CrossrefMedlineGoogle Scholar38. WyngaardenKeitelIsselbacker JBHGJ: Potassium depletion and alkalosis. Their association with hypertension and renal insufficiency, New England J. Med. 250: 597, 1954. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: JEROME W. CONN, M.D., F.A.C.P.; LAWRENCE H. LOUIS, SCD.Affiliations: Ann Arbor, Michigan*Presented at the Thirty-sixth Annual Session of the American College of Physicians, Philadelphia, Pennsylvania, April 27, 1955.From the Division of Endocrinology and Metabolism, Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, Michigan.†This study has been supported in part by a grant from the Research and Development Board, Office of the Surgeon General, U. S. Army. 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