tbuckley/cabot-search huggingface dataset:
Adverse cutaneous reactions to anakinra in patients with rheumatoid arthritis: clinicopathological study of five patients
Authors: A.T. Vila, L. Puig, M.T. Fernandez-Figueras, A.M. Laiz, D. Vidal, A. Alomar
Journal: British Journal of Dermatology (2005)

Journal Article Adverse cutaneous reactions to anakinra in patients with rheumatoid arthritis: clinicopathological study of five patients Get access A.T. Vila, A.T. Vila Departments of Dermatology and Rheumatology, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain Antonia‐Teresa Vila, Department of Dermatology, Hospital de Son Llàtzer, Ctra. Manacor, km 4, 07198 Palma de Mallorca, Spain. E‐mail: avila@hsll.es Search for other works by this author on: Oxford Academic Google Scholar L. Puig, L. Puig Departments of Dermatology and Rheumatology, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain Search for other works by this author on: Oxford Academic Google Scholar M.T. Fernández‐Figueras, M.T. Fernández‐Figueras Department of Pathology, Hospital Universitari, Germans Trias i Pujol, Badalona, Spain Search for other works by this author on: Oxford Academic Google Scholar A.M. Laiz, A.M. Laiz Departments of Dermatology and Rheumatology, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain Search for other works by this author on: Oxford Academic Google Scholar D. Vidal, D. Vidal Departments of Dermatology and Rheumatology, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain Search for other works by this author on: Oxford Academic Google Scholar A. Alomar A. Alomar Departments of Dermatology and Rheumatology, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 153, Issue 2, 1 August 2005, Pages 417–423, https://doi.org/10.1111/j.1365-2133.2005.06635.x Published: 01 August 2005 Article history Accepted: 04 December 2004 Published: 01 August 2005
Ear, nose and throat manifestations in pemphigus vulgaris
Authors: A. España, S. Fernández, J. del Olmo, M. Marquina, M. Pretel, D. Ruba, A. Sánchez-Ibarrola
Journal: British Journal of Dermatology (2007)

Background Pemphigus vulgaris (PV) is an autoimmune disease characterized by mucocutaneous intraepithelial blisters and pathogenic autoantibodies against desmoglein 3. There are two clinical forms: mucosal (MPV) and mucocutaneous (MCPV). The frequency of ear, nose and throat (ENT) involvement in PV is not clearly defined. Only a few isolated individual cases have been reported. Objectives The objective of our study was to determine the incidence of ENT involvement in patients with PV. Patients We studied prospectively all 16 patients diagnosed with PV and treated in the Department of Dermatology of the University Clinic of Navarra between 2001 and 2005. They were 10 cases of MPV and six cases of MCPV. All patients were evaluated for ENT manifestations by endoscopic examination. Results Of the 16 patients, 13 presented with throat symptoms (81%), 12 pharyngeal (75%) and seven laryngeal symptoms (44%). Fourteen patients (88%) had active PV lesions on endoscopic evaluation (eight patients had active lesions on both pharyngeal and laryngeal mucosa, four had PV lesions only on laryngeal mucosa and two had PV lesions on pharyngeal mucosa). Laryngeal lesions were most commonly present in MPV patients. The frequency of nasal symptoms (38%) was lower than active PV lesions (62%) found on ENT examination. Oral symptoms and oral active PV lesions were the most frequent findings (94%). Only three patients with MCPV showed erosions on the external auditory canal. Conclusions As ENT endoscopy allows more extensive areas of mucosa to be examined than simple visual inspection, we recommend that it be included in the examination of all patients with PV. By obtaining more complete information concerning the extent of the disease, a more accurate diagnosis can be made, better choice of drug and dose may be decided and, ultimately, response to treatment may be improved.
Morbidity from asthma in relation to regular treatment: a community based study
Authors: L J Walsh, C A Wong, S Cooper, A R Guhan, M Pringle, A E Tattersfield
Journal: Thorax (1999)

The extent to which asthma morbidity in the community occurs in patients who are having relatively little treatment or in those on step 3 or above of the British asthma management guidelines is uncertain. We have looked at this in a community population in southern Nottinghamshire.A cross sectional review of treatment in all patients over the age of four with diagnosed asthma was carried out in five large general practices (population 38 865) in 1995/6 using computerised general practice records. The patients' usual treatment was obtained from prescription data and categorised by the appropriate step on the British guidelines on asthma management. Two measures of morbidity, the request for 10 or more short acting beta agonist inhalers a year or the need for a course of oral corticosteroids in the last year, were related to the regular treatment of the patients.Of the 3373 patients (8. 7%) given a diagnosis of asthma, the percentage on steps 1, 2, 3, 4, and 5 of treatment were 54%, 22%, 11%, 3.6%, and 1%, respectively, with a further 8% having had no treatment. During the past year 13. 6% had been prescribed 10 or more beta agonist inhalers and 12.5% had received at least one course of oral corticosteroids. Both measures occurred more frequently in patients taking more prophylactic treatment (step 3 or above). Nevertheless, because most patients were on steps 1 and 2 of the treatment guidelines, more than half the patients requiring high doses of inhaled beta agonists or a course of oral prednisolone came from those taking low dose or no regular inhaled corticosteroid.Evidence of morbidity from asthma was found in many patients taking little or no prophylactic medication and this should be amenable to improved education. A different approach may be needed for patients with continuing morbidity who are already taking higher doses of prophylactic medication.
Multifocal Myoclonus Induced by Trimethoprim–Sulfamethoxazole Therapy in a Patient with Nocardia Infection
Authors: Elie G. Dib, Steven Bernstein, Curtis Benesch
Journal: New England Journal of Medicine (2003)

To the Editor: A 63-year-old woman with a history of non-Hodgkin's lymphoma that had been treated 25 years previously, as well as a history of hypertension, hypercholesterolemia, transient ischemic...
Genetic Variants in Oxidative Stress–Related Genes Predict Chemoresistance in Primary Breast Cancer: A Prospective Observational Study and Validation
Authors: Ke-Da Yu, A-Ji Huang, Lei Fan, Wen-Feng Li, Zhi-Ming Shao
Journal: Cancer Research (2011)

Chemotherapy response in patients with primary breast cancer is difficult to predict and the role of host genetic factors has not been thoroughly investigated. We hypothesized that polymorphisms in oxidative stress (OS)-related genes, including estrogen-quinone metabolizing enzymes NQO2 and GSTM1-5, may influence disease progression and treatment response. In this prospective observational study, nineteen polymorphisms tagging known variations in candidate genes were genotyped and analyzed in 806 patients with primary breast cancer. Three functional polymorphisms, which were shown to affect gene expression levels in experiments in vitro and ex vivo, modified the effect of chemotherapy on disease-free survival. There were significant interactions between chemotherapy and individual polymorphisms or combined genotypes (designated as genetic score). Patients harboring high genetic score had a 75% reduction in the hazard of disease progression compared with patients with low genetic score when no chemotherapy was administered (HR = 0.25, 95% CI: 0.10-0.63, P = 0.005); however, they received much less survival benefit from adjuvant chemotherapy compared with patients with low genetic score when chemotherapy was administered (HR = 4.60 for interaction, 95% CI: 1.63-13.3, P = 0.004). These findings were validated in another population (n = 339). In conclusion, germline polymorphisms in OS-related genes affect chemotherapy sensitivity in breast cancer patients. Although reduced OS levels might prevent breast cancer progression, they probably compromise the effectiveness of adjuvant chemotherapy. Our findings also indicate that host-related factors must be considered for individualized chemotherapy.
Pediatric Hand and Upper Limb Surgery: A Practical Guide
Authors: Robert J. Bielski
Journal: JAMA (2012)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Bethune's China
Authors: Richard A. Evans
Journal: JAMA (1980)

<h3>To the Editor.—</h3> The article by William C. Gibson, MD (242:2091, 1979), entitled "Bethune's China" was a timely tribute to Dr Norman Bethune. Gibson states, "Every schoolchild in China today memorizes Mao's brief but touching essay memorializing Bethune." I was disappointed that Dr Gibson did not include Mao's eulogy. Every communist should learn from comrade Bethune's spirit of selfless dedication, his commitment to his work, his love and respect of other comrades, and the people. (This eulogy was translated by a young Chinese-American for me.)
Prevention of Injury to Urethra by Foley Catheter
Authors: George Milles
Journal: JAMA (1967)

<h3>To the Editor:—</h3> Identification of certain hemorrhagic lesions of the urinary bladder, resulting from the use of unvented indwelling catheters,<sup>1</sup>whet my interest in other potential dangers inherent in the ever increasing use of indwelling catheters. One that has been observed elsewhere, though I have not seen it, results from the inflation of the retention balloon of a Foley catheter while it is in the urethra and before the tip of the catheter and the balloon have passed into the bladder. The increasing use of ancillary personnel, not always knowledgeable in the hazards of the procedures they are called upon to perform, makes this an accident waiting to happen. I reproduced this situation in a fresh male cadaver by inflating the balloon of a standard Foley catheter as it rested in the pars membranacea. The shaft of the penis was dissected free, and the distention of the urethra by
Clinical Implications of the Cancer Genome
Authors: Laura E. MacConaill, Levi A. Garraway
Journal: Journal of Clinical Oncology (2010)

Cancer is a disease of the genome. Most tumors harbor a constellation of structural genomic alterations that may dictate their clinical behavior and treatment response. Whereas elucidating the nature and importance of these genomic alterations has been the goal of cancer biologists for several decades, ongoing global genome characterization efforts are revolutionizing both tumor biology and the optimal paradigm for cancer treatment at an unprecedented scope. The pace of advance has been empowered, in large part, through disruptive technological innovations that render complete cancer genome characterization feasible on a large scale. This article highlights cardinal biologic and clinical insights gleaned from systematic cancer genome characterization. We also discuss how the convergence of cancer genome biology, technology, and targeted therapeutics articulates a cohesive framework for the advent of personalized cancer medicine.
The Use of Continuous Insulin Delivery Systems in Severely Insulin- Resistant Patients
Authors: Julio Wainstein, Muriel Metzger, Isaiah D. Wexler, Joseph Cohen, Itamar Raz
Journal: Diabetes Care (2001)

Obese type 2 diabetic patients with severe insulin resistance tend to develop chronic hyperglycemia, despite maximal treatment with diet, physical exercise, and oral hypoglycemic agents. Insulin therapy in these patients usually does not lead to satisfactory glucose control, even when the insulin dosage is very high. High doses of insulin also cause weight to increase, which aggravates insulin resistance and exacerbates other cardiovascular risk factors.

Continuous subcutaneous insulin infusion (CSII) provided by an insulin pump reduces the incidence of both …
Radioimmunoselntigraphy with MAb 174H.64 in Head &amp; Neck Cancer Patients
Authors: A. J. B, G. D. MacLcan, L. Golberg, G. R. Boniface, S. McQuarrie, I. Akram, K. Golberg, G. Amyotte, A. A. Noujalm
Journal: Clinical Nuclear Medicine (1994)

B, A. J. McEwan1; MacLcan, G. D.1; Golberg, L.2; Boniface, G. R.2; McQuarrie, S.3; Akram, I.1; Golberg, K.1; Amyotte, G.1; Noujalm, A. A.2 Author Information
CNS Effects of Mitral Commissurotomy
Authors: Donald F. Klein, Max Pollack
Journal: JAMA (1964)

<h3>To the Editor:—</h3> Herbert and Movius (<i>JAMA</i><b>187</b>:767 [March 7] 1964) claim that mitral commissurotomy is not necessarily followed by psychological deficit. In their study, patients took psychological tests before, and five weeks after, commissurotomy, with no significant differences in the results. It was therefore concluded that central nervous system damage did not occur to a detectable degree in these patients. However, omission of a control group renders the significance of this finding moot, since a control group may very well have demonstrated the frequently described<i>practice effect increment</i>(improvement brought about by familiarity with the tests). In our studies of psychiatric patients, the mean Wechsler-Bellevue intelligence quotient did not change after five weeks of chlorpromazine administration, but the placebo group showed a markedly significant sevenpoint<i>practice effect increment</i>after five weeks, thus indicating that chlorpromazine was actually causing a defect. Similarly, the absence of a practice effect in
Surgery and Neurodevelopmental Outcome of Very Low-Birth-Weight Infants
Authors: Frank H. Morriss, Shampa Saha, Edward F. Bell, Tarah T. Colaizy, Barbara J. Stoll, Susan R. Hintz, Seetha Shankaran, Betty R. Vohr, Shannon E. G. Hamrick, Athina Pappas, Patrick M. Jones, Waldemar A. Carlo, Abbot R. Laptook, Krisa P. Van Meurs, Pablo J. Sánchez, Ellen C. Hale, Nancy S. Newman, Abhik Das, Rosemary D. Higgins
Journal: JAMA Pediatrics (2014)

Reduced death and neurodevelopmental impairment among infants is a goal of perinatal medicine. To assess the association between surgery during the initial hospitalization and death or neurodevelopmental impairment of very low-birth-weight infants. A retrospective cohort analysis was conducted of patients enrolled in the National Institute of Child Health and Human Development Neonatal Research Network Generic Database from 1998 through 2009 and evaluated at 18 to 22 months' corrected age. Twenty-two academic neonatal intensive care units participated. Inclusion criteria were birth weight 401 to 1500 g, survival to 12 hours, and availability for follow-up. A total of 12 111 infants were included in analyses. Surgical procedures; surgery also was classified by expected anesthesia type as major (general anesthesia) or minor (nongeneral anesthesia). Multivariable logistic regression analyses planned a priori were performed for the primary outcome of death or neurodevelopmental impairment and for the secondary outcome of neurodevelopmental impairment among survivors. Multivariable linear regression analyses were performed as planned for the adjusted mean scores of the Mental Developmental Index and Psychomotor Developmental Index of the Bayley Scales of Infant Development, Second Edition, for patients born before 2006. A total of 2186 infants underwent major surgery, 784 had minor surgery, and 9141 infants did not undergo surgery. The risk-adjusted odds ratio of death or neurodevelopmental impairment for all surgery patients compared with those who had no surgery was 1.29 (95% CI, 1.08-1.55). For patients who had major surgery compared with those who had no surgery, the risk-adjusted odds ratio of death or neurodevelopmental impairment was 1.52 (95% CI, 1.24-1.87). Patients classified as having minor surgery had no increased adjusted risk. Among survivors who had major surgery compared with those who had no surgery, the adjusted risk of neurodevelopmental impairment was greater and the adjusted mean Bayley scores were lower. Major surgery in very low-birth-weight infants is independently associated with a greater than 50% increased risk of death or neurodevelopmental impairment and of neurodevelopmental impairment at 18 to 22 months' corrected age. The role of general anesthesia is implicated but remains unproven.
Is the Principle of Proportionality Sufficient to Guide Physicians’ Decisions Regarding Withholding/Withdrawing Life-Sustaining Treatment After Suicide Attempts?
Authors: Stanley A. Terman
Journal: The American Journal of Bioethics (2013)

Click to increase image sizeClick to decrease image size Acknowledgments The author wishes to acknowledge helpful critical input from Karl Steinberg, MD, CMD, and Ronald Hamel, PhD.
Infection With HTLV-III/LAV and Transfusion-Associated Acquired Immunodeficiency Syndrome
Authors: Harold W. Jaffe
Journal: JAMA (1985)

We studied patients with transfusion-associated acquired immunodeficiency syndrome (AIDS) and their blood donors for serologic evidence of infection with human T-cell lymphotropic virus type III/lymphadenopathyassociated virus with two enzyme-linked immunosorbent assays and a Western blot assay. All 19 patients with AIDS were seropositive by at least one test. In all 28 donor sets containing "high-risk" donors, at least one donor was seropositive by one or more tests. Of 255 donors not considered high risk, two (0.8%) were seropositive by all three tests. When 30 seropositive high-risk donors were evaluated a median of 29 months after donation, four (13%) had developed AIDS and eight (27%) had lymphadenopathy. Our findings support the hypothesis that human T-cell lymphotropic virus type III/lymphadenopathy-associated virus causes AIDS and indicate that seropositive high-risk donors may be at relatively high risk for developing AIDS or related conditions themselves. (<i>JAMA</i>1985;254:770-773)
Sudden Death: Is There a Human Stress Syndrome?
Authors: H. A. Tillmann Hein
Journal: JAMA (1987)

<h3>To the Editor.—</h3> It is still an unanswered question whether some sudden deaths, which are otherwise unexplained, are a manifestation of a "human stress syndrome"<sup>1</sup>related to malignant hyperthermia. Three deaths, ruled to be cardiac, but lacking an anatomic cause, and three other deaths (two ruled as heat stroke and one ruled as rhabdomyolysis) reported by Phillips et al<sup>2</sup>may be related to malignant hyperthermia. It is unfortunate that the clinical descriptions of these deaths do not permit a retrospective judgment of the question whether malignant hyperthermia played a role. We believe that it would be worthwhile to investigate the unclear cases further. Such an investigation might include an examination of the families of the victims. Recently, Ranklev et al<sup>3</sup>were able to demonstrate susceptibility to malignant hyperthermia in a family in which two young boys had suddenly died with no apparent anatomic cause. Both heat stroke<sup>4</sup>and rhabdomyolysis
Prognostic impact of adenosine-induced hypotension in patients undergoing vasodilator stress myocardial perfusion SPECT
Authors: Alden Abidov, None Chee Keong Ng, Sean W. Hayes, Enrique F. Schisterman, Ishac Cohen, John D. Friedman, Guido Germano, Daniel S. Berman
Journal: Journal of the American College of Cardiology (2002)
Commentaries on this month's Cardiovascular Controversy: the merits and demerits of animal experimentation From R D Starke
Authors: R. D Starke
Journal: Cardiovascular Research (1994)

Journal Article Commentaries on this month's Cardiovascular Controversy: the merits and demerits of animal experimentation From R D Starke Get access Rodman D Starke Rodman D Starke Senior Vice President, American Heart Association, Office of Scientific Affairs, National Center, Greenville Avenue, Dallas, TX, USA. Search for other works by this author on: Oxford Academic PubMed Google Scholar Cardiovascular Research, Volume 28, Issue 7, July 1994, Pages 1114–1115, https://doi.org/10.1093/cvr/28.7.1114 Published: 01 July 1994
Subspecialty Training: Is It Financially Worthwhile?
Authors: Mark J. Prashker, Robert F. Meenan
Journal: Annals of Internal Medicine (1991)

▪ Objective: To determine the financial return of additional training in a cognitive-oriented medical subspecialty (rheumatology) and in a procedure-oriented medical subspecialty (gastroenterology) relative to general internal medicine. ▪ Design: Analysis of existing data to compare lifetime discounted earnings of physicians in different medical specialties. ▪ Participants: General internists, gastroenterologists, and rheumatologists were surveyed. ▪ Main Outcome Measures: Using data from surveys conducted by Medical Economics and the American College of Rheumatology, we constructed lifetime earnings streams that allowed the calculation of the net present values of discounted lifetime earnings in general internal medicine, gastroenterology, and rheumatology. Net present values of lifetime earnings were calculated for each group at two discount rates. Sensitivity analyses were done to estimate how changes in relative income would affect calculations of the net present values. ▪ Main Results: The average net incomes before taxes for general internists, gastroenterologists, and rheumatologists in 1988 were $115 825, $201 875, and $118 056, respectively. At 5% and 10% discount rates, the net present values of the estimated career earnings stream for additional training in gastroenterology relative to general internal medicine were + $1 101 863 and + $512 952, respectively; for additional training in rheumatology relative to general internal medicine, the respective values were - $84, 748 and - $92, 467. If the incomes of general internists were decreased by 3% and the incomes of gastroenterologists were decreased by 25% to reflect the effect of potential changes due to the resource-based relative value scale (RBRVS), or if gastroenterology training were increased to 3 years and rheumatology fellowship stipends were increased by 30%, large differences would still exist between the groups. ▪ Conclusion: Gastroenterologists have an extremely large return on their additional investment in training, but rheumatologists have a negative return. When considered exclusively as a financial decision, fellowship training in a cognitive-oriented medical subspecialty such as rheumatology is a poor investment. Even major changes in reimbursement policies will not affect the relative pecuniary attractiveness of procedure-oriented medical subspecialties.