LIVER FUNCTION AND SERUM PROTEIN STRUCTURE IN GOUT
Authors: W Q WOLFSON, C COHN
Journal: Annals of Internal Medicine (1949)

Article1 March 1949LIVER FUNCTION AND SERUM PROTEIN STRUCTURE IN GOUTW. Q. WOLFSON, M.D., C. COHN, M.D., R. LEVINE, M.D., E. F. ROSENBERG, M.D., F.A.C.P., H. D. HUNT, M.D.W. Q. WOLFSON, M.D., C. COHN, M.D., R. LEVINE, M.D., E. F. ROSENBERG, M.D., F.A.C.P., H. D. HUNT, M.D.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-30-3-598 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe medical literature of the past century contains numerous references to the supposed rôle of the liver in gout.7 through 15, 23, 24, 30, 31, 42, 50, 55, 62, 63, 79Three types of hypothesis have been presented: (1) that gout results from an isolated disturbance in some hepatic enzyme, (2) that gout results from chronic diffuse hepatic impairment, and (3) that hepatic impairment is a frequent visceral complication of gout. The first hypothesis is as yet difficult to evaluate, since suitable methods of study have only recently become available.31, 32, 33The latter two hypotheses may be evaluated by...Bibliography1. LOEB RF: Plasma proteins in health and disease, New Eng. Jr. Med., 1941, ccxxiv, 980. CrossrefGoogle Scholar2. BOYD WC: Fundamentals of Immunology, 2nd Ed., 1947, Interscience Publishers, New York. Google Scholar3. FICARRAADAMS BJR: Postoperative gouty arthritis, Arch. Surg., 1945, l, 229. CrossrefGoogle Scholar4. FICARRA BJ: Significance of hyperuricemia in surgery, Am. Jr. Surg., 1947, lxxiii, 363. CrossrefGoogle Scholar5. WOLFSONCOHNCALVARYICHIBA WQCEF: Studies in serum proteins. V. A rapid procedure for the estimation of total protein, true albumin, total globulin, alpha globulin, beta globulin and gamma globulin in 1.0 ml. of serum, Am. Jr. Clin. Path., 1948, xviii, 723. CrossrefGoogle Scholar6. WOLFSONCOHNCALVARYTHOMAS WQCEEM: Studies in serum proteins. IV. 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HUNT, M.D.*Received for publication July 3, 1948.From the Department of Biochemistry,† and the Department of Metabolic and Endocrine Research,† Medical Research Institute, Michael Reese Hospital; the Division of Medicine and the Arthritis Clinic, Michael Reese Hospital, Chicago; and the Department of Internal Medicine, Albany Medical College.†Aided by a grant from the Committee on Scientific Research of the American Medical Association. These Departments are also in part supported by the Michael Reese Research Foundation. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byTHE ROLE OF HORMONES IN THE PATHOGENESIS AND TREATMENT OF GOUTHyperuricemia in Health and DiseaseIdiopathic Hyperlipemia and GoutEssential HypercholesterolemiaEssential HyperlipemiaHypertriglyceridemia in GoutDie GichtRHEUMATISM AND ARTHRITIS REVIEW OF AMERICAN AND ENGLISH LITERATURE OF RECENT YEARS (TENTH RHEUMATISM REVIEW)* Part IIWILLIAM D. ROBINSON, M.D., F.A.C.P., EDWARD W. BOLAND, M.D., F.A.C.P., JOSEPH J. BUNIM, M.D., F.A.C.P., DARRELL C. CRAIN, M.D., F.A.C.P., EPHRAIM P. ENGLEMAN, M.D., F.A.C.P., WALLACE GRAHAM, M.D., F.R.C.P. (C), L. MAXWELL LOCKIE, M.D., F.A.C.P., MAX M. MONTGOMERY, M.D., F.A.C.P., CHARLES RAGAN, M.D., F.A.C.P., MARIAN W. ROPES, M.D., F.A.C.P., EDWARD F. ROSENBERG, M.D., F.A.C.P., CHARLEY J. SMYTH, M.D.Gout: An Unusual Case with Softening and Subluxation of the First Cervical Vertebra and Splenomegaly Result of Acth Administration and Eventual Post-Mortem Findings 1 March 1949Volume 30, Issue 3 Page: 598-614 Keywords Arthritis Enzymes Gout Hospital medicine Liver Serum proteins ePublished: 1 December 2008 Issue Published: 1 March 1949 PDF downloadLoading ...