UNRECOGNIZED AIRWAY OBSTRUCTION ASSOCIATED WITH SMOKING: A PROBABLE FORERUNNER OF OBSTRUCTIVE PULMONARY EMPHYSEMA
Authors: W FRANKLIN, F C LOWELL
Journal: Annals of Internal Medicine (1961)

Article1 March 1961UNRECOGNIZED AIRWAY OBSTRUCTION ASSOCIATED WITH SMOKING: A PROBABLE FORERUNNER OF OBSTRUCTIVE PULMONARY EMPHYSEMAWILLIAM FRANKLIN, M.D., FRANCIS C. LOWELL, M.D., F.A.C.P.WILLIAM FRANKLIN, M.D., FRANCIS C. LOWELL, M.D., F.A.C.P.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-54-3-379 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptINTRODUCTIONAn association between cigarette smoking and chronic obstructive pulmonary disease in patients has been shown by several writers.1-4 Furthermore, it has been postulated that in such patients, smoking is the cause of the obstructive process. This may be due to inflammatory changes in the lining of the airway that lead to narrowing of the lumen or to distortion of the airway so that the flow of air is impeded.If smoking is a cause of obstructive pulmonary disease, one would expect to find it in some degree among many who smoke but who do not have manifest disease, provided...Bibliography1. PhillipsPhillipsPaullPecora RWAMAMDV: Chronic bronchitis—a neglected disease entity. Dis. of Chest 26: 520, 1954. CrossrefMedlineGoogle Scholar2. LowellFranklinMichelsonSchiller FCWALIW: A note on the association of emphysema, peptic ulcer and smoking. New Engl. J. Med. 254: 123 (Jan. 19) 1956. CrossrefMedlineGoogle Scholar3. LowellFranklinMichelsonSchiller FCWALIW: Chronic obstructive pulmonary emphysema: a disease of smokers. Ann. Intern. Med. 45: 268, August, 1956. LinkGoogle Scholar4. PhillipsPhillipsThompson AMRWJL: Chronic cough: analysis of etiologic factors in a survey of 1,274 men. Ann. Intern. Med. 45: 216, August, 1956. 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Tuberc. 27: 10, Jan., 1958. Google Scholar12. MotleyKuzman HLWJ: Cigarette smoke: its effect on pulmonary function measurements. Calif. Med. 88: 211, March, 1958. MedlineGoogle Scholar13. EichGilbertAuchincloss RWRJH: The acute effects of smoking on the mechanics of respiration in chronic obstructive pulmonary emphysema. Amer. Rev. Tuberc. 76: 22, July, 1957. Google Scholar14. Franklin W: Pulmonary function tests—practical applications and limitations in general practice. Med. Clin. N. Amer., pp. 1171-1180, September, 1957. CrossrefMedlineGoogle Scholar15. FlickPaton ALRR: Obstructive emphysema in cigarette smokers. Arch. Intern. Med. 104: 518, October, 1959. CrossrefMedlineGoogle Scholar16. Heath CW: Differences between smokers and nonsmokers. Arch. Intern. Med. 101: 377, Feb., 1958. CrossrefGoogle Scholar17. HammondHorn ECD: Smoking and death rates—report on forty-four months of follow-up of 187,783 men. I. Total mortality. J. A. M. A. 166: 1159, March 8, 1958. CrossrefMedlineGoogle Scholar18. HammondHorn ECD: Smoking and death rates—report on forty-four months of follow-up of 187,783 men. II. Death rates by cause. J. A. M. A. 166: 1294, March 15, 1958. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Boston, Massachusetts*Received for publication August 3, 1960.From the Evans Memorial and Massachusetts Memorial Hospitals, and the Department of Medicine, Boston University School of Medicine; and the Medical Service, Massachusetts General Hospital and the Department of Medicine, Harvard Medical School.Dr. Franklin is Instructor of Medicine, Harvard Medical School; formerly Assistant Clinical Professor of Medicine, Boston University School of Medicine.Dr. Lowell is Assistant Professor of Medicine, Harvard Medical School; formerly Associate Professor of Medicine, Boston University School of Medicine.†Supported by a grant (E-2638) from the United States Public Health Service.Requests for reprints should be addressed to Francis C. Lowell, M.D., F.A.C.P., Massachusetts General Hospital, Boston 14, Mass. 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ROSS, M.D.Smoking and the Health of Older MenThe Morphological Spectrum of Aging and Emphysematous LungsA. AZCUY, M.D., A. E. ANDERSON JR., M.D., ALVAN G. FORAKER, M.D.Krankheiten durch Tabakrauchen 1 March 1961Volume 54, Issue 3Page: 379-386KeywordsAir flowChronic obstructive pulmonary diseaseDyspneaEmphysemaHospital medicineMedical servicesPulmonary diseases Issue Published: 1 March 1961 PDF downloadLoading ...