tbuckley/cabot-search huggingface dataset:
Abstract #4416: 2-arylthiazolidine-4-carboxylic acid amides (ATCAA) target dual pathways: Effects on the 5\#8217;-AMP-activated protein kinase (AMPK) and Akt pathways.
Authors: Chien-Ming Li, Yan Lu, Ramesh Narayanan, Duane Miller, James Dalton
Journal: Cancer Research (2009)

The 5\#8217;-AMP-Activated Protein Kinase (AMPK) and phosphatidylinositol-3-kinase (PI3-K)/AKT signaling pathways are attractive targets for cancer research. Activation of AMPK or inhibition of AKT has shown to be cytotoxic to human cancer cells  in vitro  and  in vivo . In a previous contribution from our laboratory, we developed 2-Arylthiazolidine-4-carboxylic acid amides (ATCAA) as effective cytotoxic agents in prostate cancer cell lines, with IC 50  values in the low/sub micromolar range. In LNCaP cells, we found that a potent compound in this class, ATCAA-10 activated AMPK, and greatly reduced phospho-PDK1, phospho-AKT and glycogen synthase kinase-3b (GSK-3b). In cell-free enzyme experiments, we found that ATCAA-10 did not directly affect PI3K, PDK1 or AKT, suggesting that its molecular target was located upstream of PDK1/PI3K/AKT. An inhibitor of AMPK, Compound C, blocked de-phosphorylation of AKT, suggesting cross-talk between the AMPK and AKT pathways. Flow cytometric analyses showed that cells accumulated in the sub-G1 phase when treated with 5 \#956;M of ATCAA-10, while the G1 phase fraction decreased, suggesting that LY-I-10 also induced apoptosis in LNCaP cells. Taken together; these results suggest that ATCAA-10 may act as a potential anticancer drug via effects on AMPK and AKT, resulting in the inhibition of prostate cancer cell growth.   Citation Information:  In: Proc Am Assoc Cancer Res; 2009 Apr 18-22; Denver, CO. Philadelphia (PA): AACR; 2009. Abstract nr 4416.
Abstract 12053: Adenosine Triphosphate Sensitive Potassium Kir Subunits Implicated in Cardioprotection by Diazoxide
Authors: M B Janjua, Evelyn M Kanter, Carol M Makepeace, Matt C Henn, Richard B Schuessler, Colin G Nichols, Jennifer S Lawton
Journal: Circulation (2014)

Introduction:  Adenosine triphosphate -sensitive potassium (K ATP ) channel openers provide cardioprotection in multiple models. Ion flux at an unidentified mitochondrial K ATP  channel has been proposed as the mechanism. The potassium channel subunit Kir 1.1 has been implicated as the mitochondrial channel pore forming subunit.   Hypothesis:  We hypothesized that subunit Kir 1.1 is involved in the cardioprotection (maintenance of volume homeostasis and contractility) of K ATP  channel opener diazoxide during stress (exposure to hyperkalemic cardioplegia) at the myocyte and mitochondrial levels.   Methods:  Kir subunit inhibitor Tertiapin Q was utilized to evaluate response to stress. Mouse ventricular mitochondrial volume was measured in the following groups: 100 μM diazoxide + 200μM ATP + Tertiapin Q (0.5pM, 10pM, 90pM, or 1,000pM). Mouse myocytes were exposed to Tyrode’s solution (5 min), test solution (Tyrode’s, hyperkalemic cardioplegia (CPG) stress, CPG + diazoxide, CPG + diazoxide + Tertiapin Q, Tyrode’s + Tertiapin Q, or CPG + Tertiapin Q), N=12 for all (10 min); followed by Tyrode’s (5min). Volume (mitochondrial and myocyte) and myocyte contractility were compared.   Results:  Tertiapin Q alone, or with diazoxide, did not alter mitochondrial or myocyte volume. Stress (CPG) resulted in myocyte swelling and reduced contractility that was prevented by diazoxide. Tertiapin Q prevented the cardioprotection afforded by diazoxide (volume homeostasis and maintenance of contractility) (Figure).   Conclusions:  Tertiapin Q did not alter diazoxide - induced mitochondrial swelling, but it did inhibit myocyte cardioprotection provided by diazoxide during stress. Because Tertiapin Q inhibits Kir1.1, Kir3.1, and Kir3.4, these data support that any of these Kir subunits could be involved in the cardioprotection afforded by diazoxide. However, these data suggest that mitochondrial swelling by diazoxide does not involve Kir 1.1, 3.1 or 3.4.
Abstract 51: Baseline Depressive Symptoms are Associated with Incident Hypertension in Postmenopausal Hispanic Women: Results from the Women’s Health Initiative
Authors: Lenny Lopez, Ruth E Zambrana, Gniesha Y Dinwiddie, Roberta M Ray, Sylvia Wassertheil- Smoller
Journal: Circulation (2014)

Background: Hispanic women have higher rates of depressive symptoms compared to other racial/ethnic groups. Depression has been associated with incident hypertension in multiple prior studies with mixed results. However, prior studies were limited by small numbers of Hispanic women, short followup and limited information on possible confounders. Methods: We evaluated baseline depression and incident hypertension at three years follow-up among 4,680 postmenopausal Hispanic women enrolled in the Women’s Health Initiative observational study and clinical trial. Depression was measured at baseline using the Burnam 8-item scale (combines 6 items from the Center for Epidemiological Studies Depression Scale and 2 items from the Diagnostic Interview Schedule). This scale assesses both current depressive symptoms and past depression history. Women with a calculated Burnam score ≥ 0.06 were considered to have symptoms of depression. Multinomial logistic regression was used to estimate odds of hypertension at baseline in relation to depression. We used logistic regression to estimate odds ratios and 95% confidence intervals for the association between depression and incident hypertension at three years of follow-up. All models were adjusted for multiple demographic, clinical, and behavioral covariates. Results: Of 4, 680 Hispanic women, 32% met current depression criteria at baseline. In an age-adjusted model, women with depression were more likely to be hypertensive (OR=1.25; 95% CI 1.04-1.51), although results were attenuated when adjusting for multiple covariates. Further adjustment for antidepressant use at baseline made no important differences to the estimates. Depression at baseline in normotensive Hispanic women was associated with incident hypertension at year 3 follow-up (OR=1.29; 95% CI 1.02-1.63) after adjustment for age, education, insurance, body mass index, diabetes status, hypercholesterolemia, family history of diabetes and cardiovascular disease, and participant history of CVD. Further adjustment for behavior covariates (smoking, physical activity and alcohol intake) did not attenuate the association significantly. Conclusion: In the largest study to date of older Hispanic women, baseline depression is associated with incident hypertension at three years of followup. Early detection and management of depression in older Hispanic women is essential to preventing cardiovascular sequelae.
Poisoning by Dinitro-Ortho-Cresol
Authors: D. G. Harvey, P. L. Bidstrup, J. A. L. Bonnell
Journal: BMJ (1951)

The occupational histories and mode of death of work men dying of dinitro-or/Zio-cresol (D.N.O.C.) poisoning (Bidstrup ;and Payne, 1951) suggest that D.N.O.C. is a cumulative poison. Preliminary experiments designed to show the absorption and excretion of D.N.O.C. in human volunteers support this view and illustrate the effects of absorption of further amounts of D.N.O.C. when the concentration of D.N.O.C. in the blood exceeds 10 fig. per g.
Chemoradiotherapy for stage III unresectable non-small cell lung cancer (NSCLC) : a systematic review by the European Lung Cancer Working Party (ELCWP).
Authors: Marianne Paesmans, Thierry Berghmans, Frédéric Vallot, Fabrice Branle, Jean-Jacques Lafitte, Céline Mascaux, Anne-Pascale Meert, Emmanuelle Steels, Jean-Paul Sculier
Journal: European Respiratory Journal (1999)
Novel Imaging Device
Authors: Bernard A. Schwetz
Journal: JAMA (2001)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Resolution of remodeling in eosinophilic esophagitis correlates with epithelial response to topical corticosteroids
Authors: S. S. Aceves, R. O. Newbury, D. Chen, J. Mueller, R. Dohil, H. Hoffman, J. F. Bastian, D. H. Broide
Journal: Allergy (2009)

Esophageal remodeling occurs in eosinophilic esophagitis (EE) patients but whether the components of remodeling in the subepithelium are reversible by administration of topical oral corticosteroids is unknown.We quantitated the degree of lamina propria remodeling in esophageal biopsies obtained before and after at least 3 months of therapy with budesonide in 16 pediatric EE subjects. In addition, we investigated whether corticosteroid therapy modulated vascular activation (expression of VCAM-1; level of interstitial edema), TGFbeta(1) activation (levels of TGFbeta(1), phosphorylated Smad2/3), and performed a pilot analysis of a polymorphism in the TGFbeta(1) promoter in relation to EE subjects who had reduced remodeling with budesonide therapy.EE subjects were stratified based on the presence (n = 9) or absence (n = 7) of decreased epithelial eosinophilia following budesonide. Patients with residual eosinophil counts of <or=7 eosinophils per high power field in the epithelial space (responders) demonstrated significantly reduced esophageal remodeling with decreased fibrosis, TGFbeta(1) and pSmad2/3 positive cells, and decreased vascular activation in association with budesonide therapy. Responders were more likely to have a CC genotype at the -509 position in the TGFbeta(1) promoter.Reductions in epithelial eosinophils following budesonide therapy were associated with significantly reduced esophageal remodeling.
Molecular Radiobiology of Human Cell Lines: III. Radiation-sensitizing Properties of 5-Iododeoxyuridine
Authors: R. L. Erikson, W. Szybalski
Journal: Cancer Research (1963)

Summary  The radiosensitizing effects of 5-iododeoxyuridine (IUdR) incorporation into the DNA of human cells were systematically evaluated. The mode and degree of IUdR labeling were determined by analytical equilibrium-density-gradient ultracentrifugation. X-ray sensitization was found to depend on the total degree of thymidine replacement by IUdR and not on its distribution between the DNA strands. The factor of x-ray sensitization varied from 1.2 to 3.2 for cells grown at 10 -7  to 5 × 10 -5 m IUdR, respectively. Still higher x-ray sensitization (3.7 × at 2 × 10 -5 m IUdR) was obtained under conditions of thymidylic acid synthesis inhibition (in the presence of 10 -7 m 5-fluorodeoxyuridine), although cell viability was affected by IUdR in concentrations above 10 -5 m. Equilibrium-density-gradient patterns revealed that the mode of DNA replication in D98/AG cells is of the semi-conservative type and that DNA can under-go more than one round of duplication even at the highest levels of IUdR labeling.
Increasing Support for the Treatment of Complicated Grief in Adults of All Ages
Authors: Naomi M. Simon
Journal: JAMA (2015)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Journals JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Abstract 20526: Computational Fluid Dynamics in Partial Mechanical Circulatory Support: Implications for Patient Care
Authors: Sasan Partovi, Christoph Karmonik, Fabian Rengier, Matthias Mueller-Eschner, Hagen Meredig, Hans-Ulrich Kauczor, Rawa Arif, Bastian Schmack, Matthias Karck, Arjang Ruhparwar
Journal: Circulation (2014)

Introduction: Partial mechanical circulatory support (pMCS) is used for the therapy of heart failure. The CircuLite® Pump has been introduced clinically with its inflow cannula connected to the left atrium and the outflow cannula to the right subclavian artery. Aim of our study was to visualize and quantify flow patterns using computational fluid dynamics (CFD) in CT angiography (CTA). Methods: Two heart failure patients with pMCS were imaged with ECG-gated CTA and echocardiography. CFD was performed in 3D derived from CTA using flow boundary conditions measured with ultrasound. Flow was visualized using velocity vectors of blood flow. Average velocity was calculated at 10 time points during cardiac cycle in the aorta and the innominate. Wall shear stress (WSS) was visualized on the wall of the digital model. Results: Flow reversal was observed in mid-systole for both cases distal from the origin of the innominate artery in both cases due to asynchrony of the constant flow of the device with the pulsatile flow of the heart (fig.). Maximum velocity of this back flow was 0.39 m/s in case 1 and 0.2 m/s in case 2. Therefore, further distal in the innominate artery, a region of slow and stagnant flow with low WSS at the artery wall was observed which changed during cardiac cycle. Conclusions: CFD analysis revealed an asynchronous behavior in the inducted flow patterns during systole. Further design should allow for synchronization with the native heart function. Figure: On top flow during systole for both cases (case 1 on left), below flow during diastole. WSS is shown in pseudo-color representation with red indicating high values. Flow is visualized by arrows. During systole, a region of low WSS (blue) exists in the innominate artery which is absent during systole indicating flow reversal at this location. Bottom panel: Velocity in inferior-superior direction during cardiac cycle for both cases. Red lines demonstrates change of direction of flow in the innominate during systole.
Bir Göğüs Cerrahı Lenf Nodu Metastazlarını Ameliyat Esnasında Lenf Nodunun Boyutuna Bakarak Tespit Edebilir mi
Authors: Ryuichi Suemitsu, Sadanori Takeo, Hironori Matsuzawa, Masafumi Yamaguchi, Seiya Momosaki, Noriko Uesugi
Journal: Journal of Thoracic Oncology (2010)
Methotrexate or fumarates: which is the best oral treatment for psoriasis?
Authors: J.N.W.N. Barker
Journal: British Journal of Dermatology (2011)

Funding sources None. Conflicts of interest None declared. The advent of biologic therapy for moderate and severe psoriasis has highlighted the need for better randomized controlled trials of oral systemic therapies. These data are needed for many reasons which include the need to establish robust efficacy and safety data for them and to set a yardstick for the biological treatments. This latter point is all the more important in the EU (including the U.K.) where the licence for biologics demands prior consideration or usage of standard systemics. Furthermore, it is important that these drugs are assessed head to head in order for clinicians to determine the relative merits of one drug compared with another. Although only licensed in Germany, fumaric acid esters (FAE) are suggested by many to be a useful alternative to standard systemic therapy for psoriasis. Importantly, their mode of action is very different from that of the other available agents. The paper by Fallah Arani et al.1 in this issue examines FAE efficacy against methotrexate, often regarded as the gold standard for systemic therapy and so far the only oral agent used in active comparator studies of biologics. The authors report a 50% reduction in Psoriasis Area and Severity Index (PASI) at 12 weeks of 42% for FAE and 60% for methotrexate and a 75% PASI reduction of 19% for FAE and 24% for methotrexate. Two patients (8%) in the FAE group and four (16%) patients in the methotrexate group dropped out because of side‐effects. None of these differences was statistically significant. The authors concluded that compared with methotrexate with its inherent problems of long‐term toxicity, FAE performed well but with a favourable safety profile.
1986 Year Book of Sports Medicine.
Authors: Roy J. Shephard, David C. Nieman, Robert C. Cantu
Journal: Annals of Internal Medicine (1987)

Year Book of Sports Medicine brings you abstracts of articles carefully selected from more than 500 journals worldwide. Expert commentaries evaluate the clinical importance of each article and discuss its application to your  Editor-in-Chief Roy Shephard states: ...Not only does a team of top international experts select the very best articles from a bewildering plethora of recent information, but their expert critique of the individual papers allows readers to weigh their limitations and understand findings that can enhance their current medical  There's no faster or easier way to stay informed! Topics include Epidemiology, Prevention of Injuries, Lesions of Head and Neck; Musculoskeletal Injuries; Biomechanics, Muscle Strength, and Training; Physical Activity, Cardiorespiratory Physiology, and Immune Function; Nutrition and Doping; and Special Considerations: Children, Women, the Elderly, and Special Populations. The chief and associate editors of the book are highly knowledgeable scientific experts on this topic. Expert commentaries from the editors evaluate the clinical importance of each article and discuss its application to sports medicine practice. Reviewed by: Ufuk Sekir, Medical School of Uludag University on behalf of the Journal of Sports Science & Medicine Date: July 2015
PGC-1 promotes insulin resistance in liver through PPAR-α-dependent induction of TRB-3
Authors: Seung-Hoi Koo, Hiroaki Satoh, Stephan Herzig, Chih-Hao Lee, Susan Hedrick, Rohit Kulkarni, Ronald M Evans, Jerrold Olefsky, Marc Montminy
Journal: Nature Medicine (2004)
A major susceptibility locus for atopic dermatitis maps to chromosome 3q21
Authors: Young-Ae Lee, Ulrich Wahn, Rainer Kehrt, Luigi Tarani, Luisa Businco, Dan Gustafsson, Florence Andersson, Arnold P. Oranje, Albert Wolkertstorfer, Andrea v. Berg, Ute Hoffmann, Wolfgang Küster, Thomas Wienker, Franz Rüschendorf, André Reis
Journal: Nature Genetics (2000)
Penile Cancer
Authors: Peter E. Clark, Philippe E. Spiess, Neeraj Agarwal, Matthew C. Biagioli, Mario A. Eisenberger, Richard E. Greenberg, Harry W. Herr, Brant A. Inman, Deborah A. Kuban, Timothy M. Kuzel, Subodh M. Lele, Jeff Michalski, Lance Pagliaro, Sumanta K. Pal, Anthony Patterson, Elizabeth R. Plimack, Kamal S. Pohar, Michael P. Porter, Jerome P. Richie, Wade J. Sexton, William U. Shipley, Eric J. Small, Donald L. Trump, Geoffrey Wile, Timothy G. Wilson, Mary Dwyer, Maria Ho
Journal: Journal of the National Comprehensive Cancer Network (2013)

Squamous cell carcinoma of the penis represents approximately 0.5% of all cancers among men in the United States and other developed countries. Although rare, it is associated with significant disfigurement, and only half of the patients survive beyond 5 years. Proper evaluation of both the primary lesion and lymph nodes is critical, because nodal involvement is the most important factor of survival. The NCCN Clinical Practice Guidelines in Oncology for Penile Cancer provide recommendations on the diagnosis and management of this devastating disease based on evidence and expert consensus.
Development of a quantitative real time RT-PCR for human telomerase reverse transcriptase (hTERT) splice variants
Authors: Eleni Mavroyiannou, Aliki Stathopoulou, Evi S. Lianidou
Journal: Cancer Research (2006)

4998   Telomerase is a cellular ribonucleoprotein reverse transcriptase that synthesizes telomeric DNA onto chromosomal ends, using a segment of its own RNA as a template. Interest in the potential application of telomerase as a diagnostic and prognostic tumor marker is growing steadily since greater than 85% of most human tumors express telomerase activity, in contrast to most healthy tissues. Human telomerase reverse transcriptase (hTERT) is the enzyme’s catalytic subunit. Expression of the functional hTERT protein is a prerequisite for acquisition of telomerase activity. However, it is very important, especially for the diagnostic application of hTERT assays, to note that the presence of alternatively hTERT spliced variants, with critical reverse transcriptase motifs deleted, has been shown. In the present study, we have developed a quantitative real-time RT-PCR for the detection of four individual hTERT splice variants (α+/β+, α-/β+, α+/β- and α-/β-) and evaluate its clinical potential. A quantitative real-time RT-PCR assay for each hTERT splice variant was developed using the LightCycler technology. Specific amplification of each hTERT splice variant was performed using in silico designed and highly specific primers. The same TaqMan probe was used for the detection of all the splice variants. To determine the absolute copy number of the target transcripts, PCR amplicon based calibrators were used in order to generate four calibration curves, one for each splice variant. The human mammary carcinoma cell line MCF-7 was used for the development and validation of the method. All samples were tested for RNA integrity and cDNA quality by PCR amplification of the HPRT housekeeping gene. Quantification of hTERT splice variants was performed in six cancer cell lines (MCF-7, Colo-205, MDA-MB-231, T47D, K562 and Hela). The α+β- splice variant had the highest expression of all the alternative splice variants, while the α-β- splice variant had the lowest α-β+ and α-β- alternative splice variants were of low intensity in all cancerous cell lines. The developed method is highly specific, sensitive and rapid, and can be used for the quantitative determination of each individual hTERT splice variant in a variety of clinical samples, thus contributing to a better understanding of their biological role.
A DNA Hypomethylation Signature Predicts Antitumor Activity of LSD1 Inhibitors in SCLC
Authors: Helai P. Mohammad, Kimberly N. Smitheman, Chandrashekhar D. Kamat, David Soong, Kelly E. Federowicz, Glenn S. Van Aller, Jess L. Schneck, Jeffrey D. Carson, Yan Liu, Michael Butticello, William G. Bonnette, Shelby A. Gorman, Yan Degenhardt, Yuchen Bai, Michael T. McCabe, Melissa B. Pappalardi, Jiri Kasparec, Xinrong Tian, Kenneth C. McNulty, Meagan Rouse, Patrick McDevitt, Thau Ho, Michelle Crouthamel, Timothy K. Hart, Nestor O. Concha, Charles F. McHugh, William H. Miller, Dashyant Dhanak, Peter J. Tummino, Christopher L. Carpenter, Neil W. Johnson, Christine L. Hann, Ryan G. Kruger
Journal: Cancer Cell (2015)