THE EFFECT OF ANTIMICROBIAL DRUGS ON THE STAPHYLOCOCCAL FLORA OF HOSPITAL PATIENTS
Authors: V KNIGHT, A C WHITE, M P MARTIN
Journal: Annals of Internal Medicine (1958)

Article1 September 1958THE EFFECT OF ANTIMICROBIAL DRUGS ON THE STAPHYLOCOCCAL FLORA OF HOSPITAL PATIENTSVERNON KNIGHT, M.D., F.A.C.P., ARTHUR C. WHITE, M.D., MARGARET P. MARTIN, Ph.D.VERNON KNIGHT, M.D., F.A.C.P.Search for more papers by this author, ARTHUR C. WHITE, M.D.Search for more papers by this author, MARGARET P. MARTIN, Ph.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-49-3-536 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptAn understanding of the role of drug resistance in current problems with staphylococcal infections will depend in part upon knowledge of the way in which antimicrobial therapy causes drug-resistant staphylococci to develop and persist in hospital patients. Observations in this laboratory suggest that these effects are produced by rather specific mechanisms, and a description of them is the purpose of this report.THE "REPLACEMENT" PHENOMENONHospital patients who are staphylococcal carriers are an essential part of the chain of events leading to hospital cross-infections with drug-resistant staphylococci, for it is by the treatment of these carriers that drug-resistant staphylococci are...Bibliography1. KnightWhite VAC: Drug resistant staphylococci: their distribution in hospital patients, South. M. J. 49: 1173, 1956. CrossrefMedlineGoogle Scholar2. DuncanCollinsNeelinRoy IBAMEMTE: Nasal carriage of Staphylococcus pyogenes by student nurses, Canad. M. A. J. 77: 1001, 1957. MedlineGoogle Scholar3. KnightHolzer VA: Studies on staphylococci from hospital patients. I. Predominance of strains of group III phage patterns which are resistant to multiple antibiotics, J. Clin. Investigation 33: 1190, 1954. CrossrefMedlineGoogle Scholar4. KnightWhiteFosterWenzel VAFT: Studies on staphylococci from hospital patients. II. Effect of antimicrobial therapy and hospitalization on carrier rates, Ann. New York Acad. Sc. 65: 206, 1956. CrossrefMedlineGoogle Scholar5. Unpublished data from this laboratory. Google Scholar6. BlairCarr JEM: Staphylococci in hospital-acquired infections. Types encountered in the United States, J. A. M. A. 166: 1192, 1958. CrossrefMedlineGoogle Scholar7. BarberWhitehead MJE: Bacteriophage type of penicillin-resistant staphylococcal infection, Brit. M. J. 2: 565, 1949. CrossrefMedlineGoogle Scholar8. Tulloch LG: Nasal carriage in staphylococcal skin infections, Brit. M. J. 2: 912, 1954. CrossrefMedlineGoogle Scholar9. KnightCollins VHS: A current view on the problem of drug-resistant staphylococci and staphylococcal infection, Bull. New York Acad. Med. 31: 549, 1955. MedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: *From the Symposium on Staphylococcal Infections, presented at the Thirty-ninth Annual Session of The American College of Physicians, Atlantic City, New Jersey, April 29, 1958.From The George Hunter Laboratory of the Department of Medicine, and the Department of Preventive Medicine, School of Medicine, Vanderbilt University, Nashville, Tennessee.†Supported by grant E 845c, National Institute of Allergy and Infectious Diseases, Department of Health, Education, and Welfare, and from Lederle Laboratories Division, American Cyanamid Company, Pearl River, N. Y.Requests for reprints should be addressed to Vernon Knight, M.D., Vanderbilt Hospital, Twenty-first Street and Edgehill Road, Nashville 5, Tennessee. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byStaphylococcus aureus Nasal Carriage and Infection in Patients on HemodialysisMicrobiology of Specialized Sites in Relation to InfectionEpidemiologie Studies of an Outbreak of Nosocomial Methicillin-Resistant Staphylococcus aureus InfectionsInfection in the Surgical Patient: An Imbalance in the Normal EquilibriumBiology of surgical infectionA Staphylococcal Isolation Service Epidemiologic and Clinical Studies Over One YearWARD E. BULLOCK, M.D., JAMES W. HALL III, M.D., WESLEY W. SPINK, M.D., LEON J. DAMSKY, PH.D., VELVYL W. GREENE, PH.D., DONALD VESLEY, M.S., HENRY BAUER, PH.D.Some aspects of nasal carriage of staphylococciHEALTHY CARRIAGE OF STAPHYLOCOCCUS AUREUS : ITS PREVALENCE AND IMPORTANCEStudies of the Epidemiology of Staphylococcal InfectionChanges in the Flora of Urinary Tract Infections during Antibacterial TherapyStaphylococcal Infections in HospitalsStaphylococcal Epidemiology on a Surgical WardChemoprophylaxis of infectious diseasesIncreased Transmissibility of Staphylococci to Patients Receiving an Antimicrobial DrugStudies on the origin of drug-resistant staphylococci in a mental hospital 1 September 1958Volume 49, Issue 3Page: 536-543KeywordsAntibiotic resistanceAntimicrobialsDrug therapyDrugsInfectious diseasesPreventive medicineResearch laboratoriesRiversStaphylococcal infectionStaphylococcus ePublished: 1 December 2008 Issue Published: 1 September 1958 PDF downloadLoading ...