ARSPHENAMINE POISONING WITH REPORT OF FOUR CASES
Authors: Gerald C. Parker, Orman C. Perkins
Journal: Annals of Internal Medicine (1940)

Article1 February 1940ARSPHENAMINE POISONING WITH REPORT OF FOUR CASESGERALD C. PARKER, M.D., ORMAN C. PERKINS, M.A., M.D., F.A.C.P.GERALD C. PARKER, M.D.Search for more papers by this author, ORMAN C. PERKINS, M.A., M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-13-8-1306 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptPrevious reports concerning the toxicity of arsphenamine have described effects ranging in severity from local skin reactions to sudden death. In a recent contribution by Globus and Ginsburg, the literature has been very ably reviewed. They advance their theory as to the pathological process for which they propose a new name, "pericapillary encephalorrhagia." The pathogenesis of this process has received much consideration from others, notably Oliver and his co-workers, whose description of experimental lesions is the basis of our observations.Joseph and Fleig showed that acid arsphenamine produced reactions due to intervascular precipitation which did not occur with alkaline disodium...References1. GLOBUSGINSBURG JHSW: Pericapillary encephalorrhagia due to arsphenamine: so-called arsphenamine encephalitis, Arch. Neurol. and Psych., 1933, xxx, 1226. CrossrefGoogle Scholar2. OLIVERYAMADAKOLOS JSF: Biologic reactions of arsphenamin. VI. The reduction of its toxicity by combination with hydrophil colloids, Arch. Dermat. and Syph., 1923, n. s., viii, 1. Google Scholar3. OLIVERDOUGLAS JE: Biological reactions of arsphenamine, Jr. Pharmacol. and Exper. Therap., 1922, xix. Google Scholar4. HANZLIKKARSNER PJHT: Effects of various colloids and other agents which produce anaphylactoid phenomena on bronchi of perfused lungs, Jr. Pharmacol. and Exper. Therap., 1919-1920, xiv, 449-461. HANZLIK, P. J., and KARSNER, H. T.: Effects of various colloids and other agents which produce anaphylactoid phenomena on surviving intestine and uterus, Jr. Pharmacol. and Exper. Therap., 1919-1920, xiv, 463-478. Google Scholar5. OLIVERYAMADA JS: II. The protective action of hydrophylic colloids on the agglutination of red blood cells by arsphenamine, Jr. Pharmacol. and Exper. Therap., 1922-1923, xix, 199-206. Google Scholar6. PLASSWOODS EDEB: Hemorrhagic encephalitis (neoarsphenamine) in obstetric patients, Am. Jr. Obst. and Gynec. 1935, xxix, 509-517. CrossrefGoogle Scholar7. PRITZI O: Ein Fall von Salvarsanencephalitis in der Schwangerschaft, Zentralbl. f. Gynäk., 1928, lii, 2930-2936. Google Scholar8. COLEDEWOLFMCKUSKEYMISKJIANWILLIAMSONRAUSCHKOLBRUCHCLARK HNHJMHGGSJRROT: Toxic effects following use of arsphenamines, Jr. Am. Med. Assoc., 1931, xcvii, 897-904. CrossrefGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Brooklyn, New York*Received for publication July 30, 1937. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited bySektionserfahrungen bei Arsenobenzoltodesfällen 1 February 1940Volume 13, Issue 8Page: 1306-1316KeywordsLesionsPathogenesisSkin reactionToxicity ePublished: 1 December 2008 Issue Published: 1 February 1940 PDF downloadLoading ...