THE EFFECT OF PILOCARPINE ON THE VOLUME, FREE AND COMBINED ACID, TOTAL CHLORIDES AND PEPSIN OF GASTRIC SECRETION; AND A COMPARISON WITH THE EFFECTS OF HISTAMINE STIMULATION
Authors: Leo. J. Meienberg, Charles L. Brown
Journal: Annals of Internal Medicine (1933)

Article1 December 1933THE EFFECT OF PILOCARPINE ON THE VOLUME, FREE AND COMBINED ACID, TOTAL CHLORIDES AND PEPSIN OF GASTRIC SECRETION; AND A COMPARISON WITH THE EFFECTS OF HISTAMINE STIMULATIONLEO. J. MEIENBERG, M.D., CHARLES L. BROWN, M.D., F.A.C.P.LEO. J. MEIENBERG, M.D.Search for more papers by this author, CHARLES L. BROWN, M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-7-6-762 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptA study of the effect of pilocarpine on the various constituents of the gastric juice has been made. The results have been compared with those obtained following histamine stimulation.MATERIALStudies were made in 13 cases. These included four normal people, four cases of pernicious anemia, two duodenal ulcers, one gastric carcinoma and two functional cases.METHODSAll subjects were studied under fasting conditions, the fast beginning after the evening meal on the previous day. A Rehfuss tube with an olive tip was used for aspiration. A method of continuous aspiration by means of a water pump was employed, as...Bibliography1. ENGELBACHBROWN FCL: Variations in the volume and in the acid content of gastric secretion of normal individuals following stimulation by histamine, ANN. INT. MED., 1933, vi, 1560-1564. Google Scholar2. SIEVERSCOOK EFJE: Competency of Rehfuss tube as complete evacuator, Jr. Lab. and Clin. Med., 1932, xvii, 1120-1123. Google Scholar3. POLLAND WS: Stimulation of gastric pepsin by histamine, Jr. Clin. Invest., 1932, xi, 449-454. CrossrefGoogle Scholar4. POLLAND WS: Effect of atropine upon gastric secretion after histamine stimulation, Jr. Clin. Invest., 1930, ix, 319-432. CrossrefGoogle Scholar5. VAN SLYKE DD: Determination of chlorides in blood and tissues, Jr. Biol. Chem., 1923, lviii, 523-529. CrossrefGoogle Scholar6. POLLANDBLOOMFIELD WSAL: Quantitative method for estimation of pepsin, Jr. Clin. Invest., 1929, vii, 45-55. CrossrefGoogle Scholar7. ALTSHULER AM: Gastric secretion; its alteration by use of atropine, epinephrine and pilocarpine, Arch. Int. Med., 1928, xlii, 117-134. CrossrefGoogle Scholar8. SCHWAB E: Die Wirkung einzelner Arzneimittel auf die Magenfunktionunter gleichzeitiger Berücksichtigung von Blutdruck, Puls und Blutbild; Pilocarpinwirkung, Ztschr. f. d. ges. exper. Med., 1928, lxiii, 163-180. CrossrefGoogle Scholar9. MITROVITCH : Action of pilocarpine on the stomach, Comp. rend. Soc. d. biol.; Abstr., Jr. Am. Med. Assoc., 1926, lxxxvi, 1402. Google Scholar10. VINEBERGBABKIN AMBP: Histamine and pilocarpine in relation to the gastric secretion, Am. Jr. Physiol., 1931, xcvii, 69-73. CrossrefGoogle Scholar11. GILMANCOWGILL AGR: Effect of histamine upon secretion of gastric pepsin, Am. Jr. Physiol., 1931, xcvii, 124-130. CrossrefGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Ann Arbor, Michigan*Received for publication April 12, 1933.From the Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byEffect of Histamine on Gastric Secretion 1 December 1933Volume 7, Issue 6Page: 762-768KeywordsChloridesDuodenal ulcersGastric ulcersHistaminePepsinsPernicious anemia ePublished: 1 December 2008 Issue Published: 1 December 1933 PDF downloadLoading ...