Cytomegalovirus and Death in Liver Transplantation: Reply
Authors: Matthew E. Falagas
Journal: Annals of Internal Medicine (1997)

Letters1 September 1997Cytomegalovirus and Death in Liver Transplantation: ReplyMatthew E. Falagas, MD, MSc and David R. Snydman, MDMatthew E. Falagas, MD, MScNew England Medical Center; Boston, MA 02111Search for more papers by this author and David R. Snydman, MDNew England Medical Center; Boston, MA 02111Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-127-5-199709010-00021 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail IN RESPONSE:We appreciate Drs. Singh and Gayowski's interest in our work. We believe that considerable evidence is accumulating regarding the effect of donor and recipient CMV serologic status on mortality rates in orthotopic liver transplant recipients. By using rigorous analytical methods (including multivariate techniques to control for possible confounders), we showed an independent, clinically and statistically significant association between donor and recipient CMV serologic status and 1-year mortality rates among transplant recipients. One of the problems in interpreting results of other studies is that donor and recipient CMV serologic status may be commonly misclassified in liver transplantation because commercial ...References1. Saliba F, Farges O, Samuel D, Ichai F, David MF, Mathieu D, et al. Impact of cytomegalovirus (CMV) on morbidity and mortality after liver transplantation (LT) [Abstract]. Presented at the 35th Interscience Conference on Antimicrobial Agents and Chemotherapy; 1995. Google Scholar2. De Otero J, Gavalda J, Margarit C, Vargas V, Murio E, Rossello J, et al. Does cytomegalovirus disease (CMV) modify the patient survival after liver transplant? [Abstract] Presented at the 36th Interscience Conference on Antimicrobial Agents and Chemotherapy; 1996. Google Scholar3. Stratta RJ, Shaeffer MS, Markin RS, Wood RP, Langnas AN, Reed EC, et al. Cytomegalovirus infection and disease after liver transplantation. An overview. Dig Dis Sci. 1992; 37:673-88. Google Scholar4. Hirata M, Terasaki PI, Cho YW. Cytomegalovirus antibody status and renal transplantation: 1987-1994. Transplantation. 1996; 62:34-7. Google Scholar5. Ettinger NA, Bailey TC, Trulock EP, Storch GA, Anderson D, Raab S, et al. Cytomegalovirus infection and pneumonitis: impact after isolated lung transplantation. Am Rev Respir Dis. 1993; 147:1017-23. Google Scholar Author, Article, and Disclosure InformationAuthors: Matthew E. Falagas, MD, MSc; David R. Snydman, MDAffiliations: New England Medical Center; Boston, MA 02111 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 September 1997Volume 127, Issue 5Page: 412KeywordsCytomegalovirus infectionDeath ratesKidneysLiver transplantationLungsOrthotopic liver transplantationProphylaxisResearch designSpecificityStatistical data ePublished: 15 August 2000 Issue Published: 1 September 1997 Copyright & PermissionsCopyright © 1997 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...