RELATIONSHIP OF THE GRIESS NITRITE TEST TO BACTERIAL CULTURE IN THE DIAGNOSIS OF URINARY TRACT INFECTION
Authors: Leon G. Smith, Walter R. Thayer, Elli M. Malta, John P. Utz
Journal: Annals of Internal Medicine (1961)

Article1 January 1961RELATIONSHIP OF THE GRIESS NITRITE TEST TO BACTERIAL CULTURE IN THE DIAGNOSIS OF URINARY TRACT INFECTIONLEON G. SMITH, M.D., WALTER R. THAYER, M.D., ELLI M. MALTA, JOHN P. UTZ, M.D.LEON G. SMITH, M.D.Search for more papers by this author, WALTER R. THAYER, M.D.Search for more papers by this author, ELLI M. MALTASearch for more papers by this author, JOHN P. UTZ, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-54-1-66 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptInterest has been renewed periodically in the Griess nitrite reaction as a means of detecting bacterial infection in urine.1-4 Although it was originally employed as a test of bacterial contamination of water,5 its application as an indicator of bacteriuria was suggested by the finding that most of the bacterial species which cause urinary tract infection reduce nitrate to nitrite.In vitro studies by Kahler and Guze6have revealed that sodium nitrite in concentrations of as little as 0.1 μg. per milliliter gives a positive test. However, considerable periods of time were required for nitrate reduction by certain strains of bacteria....Bibliography1. WeltmannHaslinger OK: Die Nitritreaktion im Harn als der Harninfektion, Ztschr. f. urol. Chir. 18: 73-85, 1925. Google Scholar2. VaradySzanto JG: Untersuchungen über den Nitritgehalt des Speichels des Magensaftes und des Harnes, Klin. Wchnschr. 19: 200-203 (Mar. 2) 1940. CrossrefGoogle Scholar3. BechgaardJansen PKF: Nitritreaktion ved Urnvejsinfektion, Nord. med. 20: 2134-2136 (Dec. 4) 1943. Google Scholar4. Schaus R: Griess' nitrite test in diagnosis of urinary infection, J. A. M. A. 161: 528-529 (June 9) 1956. CrossrefMedlineGoogle Scholar5. Griess P: Bemerkungen zur Abhandlung der H. H. Weselsky und Benedickt: "Ueber einige Azoverbindungen," Berichteder deutsch. chem. gesllsch. 12: 426-428 (Mar.) 1879. CrossrefGoogle Scholar6. KahlerGuze RLLB: Evaluation of the Griess nitrite test as a method for the recognition of urinary tract infection, J. Lab. Clin. Med. 49: 934-937 (June) 1957. MedlineGoogle Scholar7. Feigl F: Spot tests in inorganic analysis, 5th Ed., 1958, Elsevier Publishing Company, Amsterdam, p. 330. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Bethesda, Maryland*Received for publication April 25, 1960.From the Infectious Disease Service, Laboratory of Clinical Investigation, the National Institute of Allergy and Infectious Diseases; from the Employee Health Service; and from the Clinical Pathology Department, Clinical Center, National Institutes of Health, U. S. Public Health Service, Department of Health, Education and Welfare, Bethesda, Maryland.Requests for reprints should be addressed to John P. Utz, M.D., Chief, Infectious Disease Service, Laboratory of Clinical Investigation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda 14, Maryland.*All examinations of urine except the Griess tests were performed by the Clinical Pathology staff of the Clinical Center, National Institutes of Health, Bethesda, Maryland. All studies were performed during 1958 and, with infrequent exception, the large series of specimens were consecutive accessions to the laboratory. 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