<i>Borrelia miyamotoi:</i> The Newest Infection Brought to Us by Deer Ticks
Authors: Peter J. Krause, Alan G. Barbour
Journal: Annals of Internal Medicine (2015)

Editorials21 July 2015Borrelia miyamotoi: The Newest Infection Brought to Us by Deer TicksPeter J. Krause, MD and Alan G. Barbour, MDPeter J. Krause, MDFrom Yale School of Public Health and Yale School of Medicine, New Haven, Connecticut, and University of California, Irvine, Irvine, California. and Alan G. Barbour, MDFrom Yale School of Public Health and Yale School of Medicine, New Haven, Connecticut, and University of California, Irvine, Irvine, California.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/M15-1219 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail It's not just Lyme disease anymore. Residents and visitors in many parts of the northeastern, north-central, and far western United States have more than one reason to avoid bites from hard-bodied (ixodid) ticks. The latest addition to the list of infections transmitted to humans by the same ixodid ticks that are vectors of Lyme disease is Borrelia miyamotoi. Although B. miyamotoi is in the same genus as B. burgdorferi, it is more closely related to species that cause relapsing fever than to Lyme disease agents (1). Discovered in Ixodes persulcatus ticks in Japan in 1994 and subsequently documented in ticks ...References1. Barbour AG. Phylogeny of a relapsing fever Borrelia species transmitted by the hard tick Ixodes scapularis. Infect Genet Evol. 2014;27:551-8. [PMID: 24813576] doi:10.1016/j.meegid.2014.04.022 CrossrefMedlineGoogle Scholar2. Platonov AE, Karan LS, Kolyasnikova NM, Makhneva NA, Toporkova MG, Maleev VV, et al. Humans infected with relapsing fever spirochete Borrelia miyamotoi, Russia. Emerg Infect Dis. 2011;17:1816-23. [PMID: 22000350] doi:10.3201/eid1710.101474 CrossrefMedlineGoogle Scholar3. Krause PJ, Fish D, Narasimhan S, Barbour AG. Borrelia miyamotoi infection in nature and in humans. Clin Microbiol Infect. 2015. [PMID: 25700888] doi:10.1016/j.cmi.2015.02.006 CrossrefMedlineGoogle Scholar4. Gugliotta JL, Goethert HK, Berardi VP, Telford SR. Meningoencephalitis from Borrelia miyamotoi in an immunocompromised patient. N Engl J Med. 2013;368:240-5. [PMID: 23323900] doi:10.1056/NEJMoa1209039 CrossrefMedlineGoogle Scholar5. Krause PJ, Narasimhan S, Wormser GP, Rollend L, Fikrig E, Lepore T, et al. Human Borrelia miyamotoi infection in the United States [Letter]. N Engl J Med. 2013;368:291-3. [PMID: 23323920] doi:10.1056/NEJMc1215469 CrossrefMedlineGoogle Scholar6. Krause PJ, Narasimhan S, Wormser GP, Barbour AG, Platonov AE, Brancato J, et al; Tick Borne Diseases Group. Borrelia miyamotoi sensu lato seroreactivity and seroprevalence in the northeastern United States. Emerg Infect Dis. 2014;20:1183-90. [PMID: 24960072] doi:10.3201/eid2007.131587 CrossrefMedlineGoogle Scholar7. Hovius JW, deWever B, Sohne M, Brouwer MC, Coumou J, Wagemakers A, et al. A case of meningoencephalitis by the relapsing fever spirochaete Borrelia miyamotoi in Europe. Lancet. 2013;382:658. [PMID: 23953389] doi:10.1016/S0140-6736(13)61644-X CrossrefMedlineGoogle Scholar8. Molloy PJ, Telford SR, Chowdri HR, Lepore TJ, Gugliotta JL, Weeks KE, et al. Borrelia miyamotoi disease in the northeastern United States. A case series. Ann Intern Med. 2015;163:91-8. doi:10.7326/M15-0333 LinkGoogle Scholar9. Scoles GA, Papero M, Beati L, Fish D. A relapsing fever group spirochete transmitted by Ixodes scapularis ticks. Vector Borne Zoonotic Dis. 2001;1:21-34. [PMID: 12653133] CrossrefMedlineGoogle Scholar10. Schwan TG, Schrumpf ME, Hinnebusch BJ, Anderson DE, Konkel ME. GlpQ: an antigen for serological discrimination between relapsing fever and Lyme borreliosis. J Clin Microbiol. 1996;34:2483-92. [PMID: 8880505] CrossrefMedlineGoogle Scholar Author, Article, and Disclosure InformationAffiliations: From Yale School of Public Health and Yale School of Medicine, New Haven, Connecticut, and University of California, Irvine, Irvine, California.Note: Drs. Krause and Barbour contributed equally to this article.Disclosures: Disclosures can be viewed at www.acponline.org/authors/icmje/ConflictOfInterestForms.do?msNum=M15-1219.Corresponding Author: Peter J. Krause, MD, Yale School of Public Health, 60 College Street, New Haven, CT 06520.Current Author Addresses: Dr. Krause: Yale School of Public Health, 60 College Street, New Haven, CT 06520.Dr. Barbour: Department of Microbiology & Molecular Genetics, University of California, Irvine, 3012 Hewitt, Mail Code 4028, Irvine, CA 92697.This article was published online first at www.annals.org on 9 June 2015. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoBorrelia miyamotoi Disease in the Northeastern United States Philip J. Molloy , Sam R. Telford III , Hanumara Ram Chowdri , Timothy J. Lepore , Joseph L. Gugliotta , Karen E. Weeks , Mary Ellen Hewins , Heidi K. Goethert , and Victor P. Berardi Borrelia miyamotoi Disease in the Northeastern United States Philip J. Molloy , Sam R. Telford III , Hanumara Ram Chowdri , Timothy J. Lepore , Joseph L. Gugliotta , Karen E. Weeks , Mary Ellen Hewins , Heidi K. Goethert , and Victor P. Berardi Borrelia miyamotoi Sam R. Telford III , Philip J. Molloy , and Victor P. Berardi Borrelia miyamotoi Peter J. Krause and Alan G. Barbour Metrics Cited byWhen to Think About Other Borreliae:Modification of the multiplex plasmid PCR assay for Borrelia miyamotoi strain LB-2001 based on the complete genome sequence reflecting genomic rearrangements differing from strain CT13–2396Interaction between Borrelia miyamotoi variable major proteins Vlp15/16 and Vlp18 with plasminogen and complementThe Prevalence of Different Human Pathogenic Microorganisms Transmitted by Ixodes Tick Vectors in BelarusLyme Disease: Diversity of Borrelia Species in California and Mexico Detected Using a Novel Immunoblot AssayArthropod Bites and Stings Treated in Emergency Departments: Recent Trends and CorrelatesKnowledge, attitudes, and behaviors regarding tick-borne disease prevention in endemic areasVertical transmission rates of Borrelia miyamotoi in Ixodes scapularis collected from white-tailed deerCombatting the Increasing Threat of Vector-Borne Disease in the United States with a National Vector-Borne Disease Prevention and Control SystemTick-Borne Infections: Beware the Tortoises Among UsSerodiagnosis of Borrelia miyamotoi disease by measuring antibodies against GlpQ and variable major proteinsNeuroborreliosisVital Signs : Trends in Reported Vectorborne Disease Cases — United States and Territories, 2004–2016The Blacklegged Tick, Ixodes scapularis : An Increasing Public Health ConcernThe Complement Binding and Inhibitory Protein CbiA of Borrelia miyamotoi Degrades Extracellular Matrix Components by Interacting with Plasmin(ogen)Immune evasion of Borrelia miyamotoi: CbiA, a novel outer surface protein exhibiting complement binding and inactivating propertiesBorrelia miyamotoi Polymerase Chain Reaction Positivity on a Tick-Borne Disease Panel in an Endemic Region of Rhode IslandIn Vitro Susceptibility of the Relapsing-Fever Spirochete Borrelia miyamotoi to Antimicrobial AgentsDevelopment and optimization of an in vitro cultivation protocol allows for isolation of Borrelia miyamotoi from patients with hard tick-borne relapsing feverBorrelia burgdorferi DNA absent, multiple Rickettsia spp. DNA present in ticks collected from a teaching forest in North Central FloridaBorrelia miyamotoi: A human tick-borne relapsing fever spirochete in Europe and its potential impact on public healthVariable Major Proteins as Targets for Specific Antibodies against Borrelia miyamotoiBorrelia miyamotoiSam R. Telford III, ScD, Philip J. Molloy, MD, and Victor P. Berardi 21 July 2015Volume 163, Issue 2Page: 141-142KeywordsAntibioticsBloodCase seriesClinical epidemiologyFeversLyme diseasePathogensRelapsing feverResearch designTicks ePublished: 21 July 2015 Issue Published: 21 July 2015 Copyright & PermissionsCopyright © 2015 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...