Hemoglobin Studies in Sarcoidosis
Authors: RICHARD J. HIRSCHMAN
Journal: Annals of Internal Medicine (1965)

Brief Communications1 January 1965Hemoglobin Studies in SarcoidosisRICHARD J. HIRSCHMAN, B.A., CAROL J. JOHNS, M.D.RICHARD J. HIRSCHMAN, B.A., CAROL J. JOHNS, M.D.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-62-1-129 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptA significantly increased frequency of hemoglobinopathies among Negro patients with sarcoidosis has been reported by Greenberg, Atwater, and Israel (1). In this report, data on the frequency of hemoglobinopathies among similar patients followed at the Johns Hopkins Hospital are presented.MATERIALS AND METHODSAll the Negro patients currently followed up in the Sarcoid Clinic at the Johns Hopkins Hospital were reviewed for confirmation of the diagnosis of sarcoidosis. The criteria included a histological diagnosis (either a positive Kveim biopsy or biopsy of involved tissue) and clinical evidence of involvement of two or more organ systems. Blood for electrophoresis was obtained...References1. GREENBERGATWATERISRAEL SRJHL: Frequency of hemoglobinopathies in sarcoidosis. Ann. Intern. Med. 62: 125, 1964. LinkGoogle Scholar2. SMITHCONLEY EWCL: Filter paper electrophoresis of human hemoglobins with special reference to the incidence and clinical significance of hemoglobin C. Bull. Hopkins Hosp. 93: 94, 1953. MedlineGoogle Scholar3. MARDERCONLEY VJCL: Electrophoresis of hemoglobin on agar gels. Bull. Hopkins Hosp. 105: 77, 1959. MedlineGoogle Scholar4. SMITHIES O: An improved procedure for starchgel electrophoresis: further variations in the serum proteins of normal individuals. Biochem. J. 71: 585, 1959. CrossrefMedlineGoogle Scholar5. CEPPELLINI R: In Ciba Foundation Symposium, Biochemistry of Human Genetics, edited by WOLSTENHOLME, G. E. W., O'CONNOR, C. M. Churchill, London, 1959, p. 134. Google Scholar6. WEATHERALL DJ: Personal communication. Google Scholar7. MYERSONHARRISONLOHMULLER RMEHW: Incidence and significance of abnormal hemoglobins. Amer. J. Med. 26: 543, 1959. CrossrefMedlineGoogle Scholar8. SCHNEIDER RG: Incidence of electrophoretically distinct abnormalities of hemoglobin in 1550 Negro hospital patients. Amer. J. Clin. Path. 26: 1270, 1956. CrossrefMedlineGoogle Scholar9. WEATHERALL DJ: Abnormal haemoglobins in the neonatal period and their relationship to thalassaemia. Brit. J. Haemat. 9: 265, 1963. CrossrefMedlineGoogle Scholar10. WHALLEYPRITCHARDRICHARDS PJJAJR: Sickle cell trait and pregnancy. JAMA 186: 1132, 1963. CrossrefMedlineGoogle Scholar11. BUCKMCKUSICK AAVA: Epidemiologic investigations of sarcoidosis. Amer. J. Hyg. 74: 195, 1961. Google Scholar12. ALLISON AC: Protection afforded by sickle-cell trait against subtertian malarial infection. Brit. Med. J. 1: 290, 1954. CrossrefMedlineGoogle Scholar13. ROBERTSHILBURG ARLE: Sickle cell disease with Salmonella osteomyelitis. J. Pediat. 52: 170, 1958. CrossrefMedlineGoogle Scholar14. WEISSSTECHER WW: Tuberculosis and the sickle-cell trait. Arch. Intern. Med. (Chicago) 89: 914, 1952. CrossrefGoogle Scholar15. RYANO'CONNORMCCURDYKATZ TJTFPRS: Sickle cell trait and tuberculosis. Amer. Rev. Resp. Dis. 81: 546, 1960. MedlineGoogle Scholar16. ROSENBLUMKABAKOWLICHTMANLYONS RBHCH: Sickle cell trait and disease in pulmonary tuberculosis. Arch. Intern. Med. (Chicago) 95: 540, 1955. CrossrefGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: RICHARD J. HIRSCHMAN, B.A.; CAROL J. JOHNS, M.D.Affiliations: Baltimore, MarylandFrom the Sarcoid Clinic, The Department of Medicine, The Johns Hopkins University School of Medicine and Hospital, Baltimore, Md.This work was supported in part by undergraduate training grant 5T5 GM-9-07, National Institutes of Health, U. S. Public Health Service, Bethesda, Md.Requests for reprints should be addressed to Carol J. Johns, M.D., Johns Hopkins Hospital, Baltimore, Md. 21205. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited bySARCOIDOSIS PRESENTING WITH MASSIVE SPLENOMEGALY IN A CHILD WITH A HISTORY OF IRIDOCYCLITIS AND SENSORINEURAL DEAFNESSThe Clinical Management of Sarcoidosis A 50-Year Experience at the Johns Hopkins Hospital 1 January 1965Volume 62, Issue 1 Page: 129-132 Keywords Biopsy Gel electrophoresis Genetics Hemoglobin Hemoglobinopathies Hospital medicine Prevention, policy, and public health Research design Sarcoidosis Undergraduates ePublished: 1 December 2008 Issue Published: 1 January 1965 PDF downloadLoading ...