tbuckley/cabot-search huggingface dataset:
The Fate of Circulating Osteoblasts
Authors: Ernesto Canalis
Journal: New England Journal of Medicine (2005)

Bone remodeling is a temporally regulated process resulting in the coordinated resorption and formation of skeletal tissue carried out in basic multicellular units throughout life.1 Signals determining the fate, function, and ultimate death of cells of the osteoclast and osteoblast lineages define the populations of cells that resorb and form bone in basic multicellular units. There, osteoblasts appear at sites vacated by osteoclasts, a process called coupling. As resorption by osteoclasts is terminated, the resorptive surface is covered by a thin layer of cement, where osteoblasts assemble to form bone and fill the cavity.2 During growth, two types of bone . . .
High levels of gene expression in the hepatocytes of adult mice, neonatal mice and tree shrews via retro-orbital sinus hydrodynamic injections of naked plasmid DNA
Authors: Shaoduo Yan, Qiuxia Fu, Yong Zhou, Jidong Wang, Ying Liu, Xiangguo Duan, Shuaizheng Jia, Jianchun Peng, Bo Gao, Juan Du, Qianqian Zhou, Yuan Li, Xiaohui Wang, Linsheng Zhan
Journal: Journal of Controlled Release (2012)
Avid FDG Uptake in the Right Ventricle Coupled with Enhanced Intercostal Muscle Hypermetabolism in Pneumoconiosis
Authors: Sandip Basu, Abass Alavi
Journal: Clinical Nuclear Medicine (2007)

Avid FDG uptake in the right ventricle (RV) coupled with features of RV hypertrophy in FDG PET can signify RV pressure overload due to underlying pulmonary hypertension and hence observation of such findings would require careful correlation. A 46-year-old man, a coal miner for 30 years presented with the referral diagnosis of pneumoconiosis for evaluation of a suspicious appearing focal irregular nodular opacity measuring 1.3 × 0.8 cm in the right upper lobe on a CT scan of the thorax. In addition, there was evidence of advanced interstitial fibrosis with nodular perilymphatic interstitial disease; prominent subpleural basilar abnormalities were noted which was in keeping with interstitial pneumonitis. Also reported was moderate cardiomegaly and mediastinal adenopathy especially in the lower right paratracheal region. He was referred for FDG PET which was done to ascertain the nature of the suspicious pulmonary nodule seen on CT of the thorax. Unusually intense FDG uptake was observed in the RV along with diffuse FDG uptake in the posterior intercostal muscles. The ratio of the SUVmax of the RV (12.1) to the left ventricle (12.9) was 0.93. This signified RV pressure overload due to underlying pulmonary hypertension proven subsequently by 2D echocardiography and arterial blood gas analysis. It is important for the PET reader to be aware of this as it can provide valuable and clinically significant information; with growing use of FDG PET, such findings are becoming increasingly evident.
Canadian doctors suggest acceptable waiting times for care
Authors: Barbara Kermode-Scott
Journal: BMJ (2005)

Seven Canadian medical organisations have joined forces to develop evidence based benchmarks for acceptable waiting times for certain types of care. Lengthy waiting times are a major concern in Canada.

In April the umbrella organisation the Wait Time Alliance of Canada released an interim report, No More Time to Wait , examining the problem of waiting times for health care in Canada.

The members of the alliance include the Canadian Medical Association, the Canadian Association of Radiologists, the Canadian Association of Nuclear Medicine, the Canadian Association of Radiation Oncologists, the Canadian Cardiovascular Society, the Canadian Ophthalmological Society, and …
Abstract 4317: Developing near infrared (NIR) optical retinoid analogue for cancer imaging
Authors: Wei Wang, Adrienne L. McNees, Arlin G. Cameron, Juliet A. Wendt, Michel E. Mawad, Shi Ke
Journal: Cancer Research (2010)

Abstract Imaging technology plays an important role in early detection of cancers and improved prognoses. Among of the various imaging techniques used near infrared (NIR) optical imaging is an active and promising area for both in vitro and in vivo molecular imaging studies. However, NIR fluorophores normally only possess optical imaging properties without selectivity to diseased tissues. To address this problem, a targeting moiety can be introduced to help to deliver the imaging report to its target. It is know that retinoids, analogs of vitamin A, are assessed for multiple therapeutic uses. In practically, their potential chemopreventive and therapeutic roles in different kinds of cancers have attracted much attention. The cancer types include head and neck, lung, breast, esophagus, colon, kidney, prostate, bladder cancers and so on. Considering about important role of retinoids in cancer treatment developing retinoid derivatives as targeting imaging agents should be a useful strategy for noninvasive detection and characterization of solid tumors. Herein, we developed fluorescent retinoid derivatives for cancer imaging. Several different cancer cell lines and cancer xenograft models were used in this study. The data demonstrate that this new imaging agent can be used to imaging different kinds of cancers from cell level to whole body. Furthermore, these imaging agents have the potential to develop into special therapeutic agents that can be used for diagnosis, treatment and monitor of retinoid positive diseases. Note: This abstract was not presented at the AACR 101st Annual Meeting 2010 because the presenter was unable to attend. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 101st Annual Meeting of the American Association for Cancer Research; 2010 Apr 17-21; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2010;70(8 Suppl):Abstract nr 4317.
Proximal Tubular Dysfunction in the Nephrotic Syndrome.
Authors: Raymond L. Sherman
Journal: Annals of Internal Medicine (1971)

Meeting Abstracts1 May 1971Proximal Tubular Dysfunction in the Nephrotic Syndrome.Raymond L. Sherman, E. Lovell Becker, F.A.C.P.Raymond L. ShermanSearch for more papers by this author, E. Lovell Becker, F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-74-5-833_1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptAbnormalities of proximal tubular function such as glycosuria, aminoaciduria, and defects in acidification have been described previously in the nephrotic syndrome. In this study proximal tubular function was tested in 22 patients with the nephrotic syndrome by measuring lysozyme and glucose urine to serum concentration ratios. Eight of the patients had renal glycosuria, with urine concentrations ranging from 35 to 186 mg/100 ml at serum values below 135 mg/100 ml. These patients had lysozyme concentrations in the urine above the normal range (greater than 2µ/ml). Four of this group has serum lysozyme concentrations in the normal range (4 to 12... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byNephrotic syndrome complicated by tubular dysfunction. Case report and review of possible mechanisms.Proteinuria 1 May 1971Volume 74, Issue 5Page: 833-833KeywordsAttentionGlucoseLysozymePatientsUrine Issue Published: 1 May 1971 PDF downloadLoading ...
A Population-based Case–Control Study of Urinary Arsenic Species and Squamous Cell Carcinoma in New Hampshire, USA
Authors: Diane Gilbert-Diamond, Zhigang Li, Ann E. Perry, Steven K. Spencer, A. Jay Gandolfi, Margaret R. Karagas
Journal: Environmental Health Perspectives (2013)

Chronic high arsenic exposure is associated with squamous cell carcinoma (SCC) of the skin, and inorganic arsenic (iAs) metabolites may play an important role in this association. However, little is known about the carcinogenicity of arsenic at levels commonly observed in the United States.
Two newly identified genetic determinants of pigmentation in Europeans
Authors: Patrick Sulem, Daniel F Gudbjartsson, Simon N Stacey, Agnar Helgason, Thorunn Rafnar, Margret Jakobsdottir, Stacy Steinberg, Sigurjon A Gudjonsson, Arnar Palsson, Gudmar Thorleifsson, Snæbjörn Pálsson, Bardur Sigurgeirsson, Kristin Thorisdottir, Rafn Ragnarsson, Kristrun R Benediktsdottir, Katja K Aben, Sita H Vermeulen, Alisa M Goldstein, Margaret A Tucker, Lambertus A Kiemeney, Jon H Olafsson, Jeffrey Gulcher, Augustine Kong, Unnur Thorsteinsdottir, Kari Stefansson
Journal: Nature Genetics (2008)
Sustained virological response in HIV/HCV co-infected patients treated with pegylated interferon/ribavirin can be predicted from the overall rate of viral load decline over the first 4 weeks of therapy
Authors: Antonio Rivero-Juarez, Karin Neukam, Pablo Labarga, Angela Camacho, Juan Macias, Pablo Barreiro, Julián Torre-Cisneros, Juan A. Pineda, Vicente Soriano, Antonio Rivero
Journal: Journal of Infection (2013)
PERFECT STENT: A PROSPECTIVE, RANDOMIZED TRIAL EVALUATING A PACLITAXEL-ELUTING BALLOON IN PATIENTS TREATED WITH ENDOTHELIAL PROGENITOR CELL CAPTURING STENTS FOR DE NOVO CORONARY ARTERY DISEASE &amp;ndash; 24 MONTHS RESULTS:
Authors: Jochen Woehrle, Ralf Birkemeyer, Sinisa Markovic, Barbara Bluem, Tomislav Miljak, Jochen Spiess, Wolfgang Rottbauer, Harald Rittger
Journal: Journal of the American College of Cardiology (2012)
The SUPPORT Project and Improving Care for Seriously III Patients
Authors: Philip J. Dougherty
Journal: JAMA (1996)

To the Editor.  —The article by the SUPPORT investigators 1 is a terrible testimony to the inertia of physicians regarding the use of advance directives and respect for autonomy. What has to happen to get physicians to realize that these issues are important, to accept the reality of patient wishes, to understand that patient rights include the patient's ability to decide on what treatment to accept or decline, and to recognize that the physician's responsibility includes initiating the discussion of these concepts? 2   It would seem we have taken several steps backward into the era that existed when I first began practice nearly 40 years ago. Physician paternalism was rampant and accepted as right and customary. Nobody questioned the physician's decisions and orders. Over the years, this slowly changed, and we thought we had witnessed the dawn of an acceptance of a partnership in the patient-physician relationship. Mutual respect, mutual
Clinical Problems With Drugs
Authors: Ronald C. DeConti
Journal: JAMA (1976)

A rapidly advancing medical technology, coupled with a blossoming pharmaceutical industry, created an increasing number of complex drugs. Despite their benefits, these have produced a rapidly growing number of adverse reactions that result in a large number of hospital admissions, major disability, and even death. In this relatively brief, easily read monograph, the authors systematically deal with adverse drug reactions. Proceeding from an initial chapter on perspectives on drug-induced diseases, the development of a formulary, and modes of regulating drug use, to an epidemiologic view of the problems of drugs for hospitalized patients, they demonstrate how adverse reactions occur more commonly as the number and duration of use increases. The authors stress the limitations of physician education and the need to increase awareness of potential toxicity. Two chapters analyze some mechanisms of toxicity and the biologic determinants of adverse reactions in normal and in ill individuals. A very simple tabular
A theoretical method for estimating small vessel distensibility in humans.
Authors: D J Patel, R N Vaishnav, B R Coleman, R J Tearney, L N Cothran, C L Currey
Journal: Circulation Research (1988)

A simple theoretical approach is presented for estimating vascular distensibility of small blood vessels from noninvasively obtained pressure-flow data in the hand and forearm of human subjects. To the extent that Poiseuille's law applies to blood flow in these vascular beds, conductance (the reciprocal of vascular resistance) can be calculated from these data as the ratio of blood flow to mean arterial pressure. The fourth root of the conductance is proportional to the radius of the vascular bed. The slope of the relation between the logarithm of the radius of the vascular bed and the transmural pressure is proportional to the vascular extensibility (E), which, in turn, for small deformations and constant vascular length, is proportional to the distensibility of small blood vessel. Data obtained from the hands of six hypertensive subjects were compared with that obtained from six normotensive subjects, all with their vascular beds in a maximally dilated state. Also compared were data obtained from four normal subjects with their vascular beds in the resting state and when the beds were maximally dilated. The results indicate that 1) in the hypertensive subjects, the small blood vessels of the maximally dilated vascular bed of the hand are significantly (p less than 0.02) less distensible (E = 0.126 +/- 0.034/mm Hg) than those in the normotensive subjects (E = 0.272 +/- 0.047/mm Hg) and 2) the small blood vessels of the normal forearm at resting levels of vasomotor tone are more distensible (E = 1.00 +/- 0.38/mm Hg) than in the maximally dilated state (E = 0.51 +/- 0.08/mm Hg).
SMON Reported in 1935 in Argentina
Authors: Kiyohiko Katahira
Journal: JAMA (1978)

<h3>To the Editor.—</h3> Kimihiro Nakae, PhD, and I reported that subacute myelo-optic neuropathy (SMON) probably occurred in 1938 in Japan (236:919,1976). Then, when and where did SMON occur first outside Japan? Recently, two pertinent articles were found that were published in 1935 in Argentina.<sup>1,2</sup>Grawitz<sup>3</sup>administered iodochlorhydroxyquin (Vioform) to 153 patients with amebiasis in a daily dose of 1.5 g for 30 days and described in one case "the development of the sensation of deafness and a paraplegic syndrome similar to transverse myelitis." However, he did not say conclusively that symptoms in this case were side effects of iodochlorhydroxyquin. The general tone of his article stressed the greater efficacy of iodochlorhydroxyquin for amebiasis compared with emetine or chiniofon (Yatren). Knowing of this report, I investigated whether<i>Quarterly Cumulative Index Medicus</i>happened to cover it and discovered a comment by Barros,<sup>4</sup>whose article was so beyond my expectation
Role Models — Guiding the Future of Medicine
Authors: Kelley M. Skeff, Sunita Mutha
Journal: New England Journal of Medicine (1998)

In this issue of the Journal, Wright et al. present provocative evidence that many physician-teachers do not exhibit the professional characteristics that residents desire to emulate.1 Assuming that this study's results, from two highly respected teaching programs, are representative of other institutions, these data indicate that less than half of teaching physicians are perceived as excellent role models. What does this mean? Do less than half of medical teachers have the skills and behavior of respected physicians? Do learners recognize the value of the professional roles of less than half of faculty members? Do less than half of clinical teachers . . .
Mixtures of four organochlorines enhance human breast cancer cell proliferation.
Authors: J Payne, M Scholze, A Kortenkamp
Journal: Environmental Health Perspectives (2001)

In view of the large differences between the concentrations of estrogenic chemicals needed to elicit effects in in vitro assays and their levels in human tissues, it is hard to explain possible health risks in terms of exposure to individual compounds. Human populations, however, are exposed to mixtures of estrogenic and estrogen-like agents and it is necessary to consider the impact of combined effects. We assessed the combined effects of 1-(o-chlorophenyl)-1-(p-chlorophenyl)-2,2,2-trichloroethane (o,p'-DDT), 2,2-bis(p-chlorophenyl)-1,1-dichloroethylene (p,p'-DDE), beta-hexachlorocyclohexane (beta-HCH), and 1,1-bis(p-chlorophenyl)-2,2,2-trichloroethane (p,p'-DDT) on the induction of cell proliferation in MCF-7 cells. All four compounds are persistent organochlorines that can be found in human tissues. We performed extensive concentration-response analyses with the single agents to predict the effects of two mixtures of all four compounds with different mixture ratios. We calculated the predictions by using the pharmacologically well-founded models of concentration addition and independent action and then tested them experimentally. o,p'-DDT, p,p'-DDE, beta-HCH, and p,p'-DDT acted together to produce proliferative effects in MCF-7 cells. The combined effect of the four agents could be predicted on the basis of data about single agent concentration-response relationships. Regression analysis demonstrated that there were combination effects even when each mixture component was present at levels at or below its individual no-observed-effect-concentration. We assessed combination effects in two ways: First, evaluations in relation to the proliferative responses induced by single mixture components revealed that the combination effects were stronger than the effects of the most potent constituent. Thus, according to this method of evaluation, the combined effects may be termed synergistic. Second, comparisons with the expected effects, as predicted by concentration addition and independent action, showed excellent agreement between prediction and observation. With this approach, the combined effect of all four compounds can be termed additive.
Chemoprevention of Hereditary Ovarian Cancer
Authors: Stephen C. Rubin
Journal: New England Journal of Medicine (1998)

Ovarian cancer is an insidious disease that kills more American women each year than all other gynecologic cancers combined. It causes no specific symptoms even when the disease is advanced, there are no effective screening tests, and risk factors for this type of cancer are not well defined. As a result, in most women, ovarian cancer is not diagnosed until extensive spread has occurred; despite the advances that have been made in the surgical and pharmacologic treatment of the disease, most women with this form of cancer die from it.Among the suggested risk factors for ovarian cancer, which include . . .
Infants with Eczema have High Rates of Sensitization to Food Allergens - results from the Leap Study
Authors: G. Roberts, G. Du Toit, P. Sayre, V. Turcanu, H.R. Fisher, D. Broide, L. Nirenstein, S. Radulovic, A. Stephens, V. Seyfert-Margolis, N. Nasser, S. Murphy, G. Lack
Journal: Journal of Allergy and Clinical Immunology (2010)
Galactorrhea and Abnormal Menses Associated With a Long-Acting Progesterone
Authors: Ronald J. Bolognese
Journal: JAMA (1967)

WE RECENTLY reported the propensity of medroxyprogesterone acetate (Depo-Provera) for causing missed abortion.<sup>1</sup>Subsequent menstrual abnormalities were noted in 15 of 22 such patients, observations also noted by others.<sup>2-4</sup>During our investigation of 58 patients treated with medroxyprogesterone, we uncovered another endocrine abnormality—persistent puerperal galactorrhea. Although other drugs have been associated with this condition, we know of no published report of abnormal lactation associated with medroxyprogresterone. This communication will present five cases in which galactorrhea developed following administration of medroxyprogesterone, as well as the menstrual response in the 36 cases not previously reported. <h3>Methods and Materials</h3> During 1964 and 1965, fifty-seven patients who received medroxyprogesterone for threatened abortion were investigated. The women ranged in age from 21 to 41 years and in parity from 0 to 10. Fifty or 100 mg weekly doses of medroxyprogresterone acetate were initiated during the first trimester in 44 patients and during the
Partial plasma cell differentiation as a mechanism of lost major histocompatibility complex class II expression in diffuse large B-cell lymphoma
Authors: Sarah T. Wilkinson, Kristie A. Vanpatten, Diane R. Fernandez, Patrick Brunhoeber, Karl E. Garsha, Betty J. Glinsmann-Gibson, Thomas M. Grogan, Julie Teruya-Feldstein, Lisa M. Rimsza
Journal: Blood (2011)
PROGNOSTIC VALUE OF PERCEPTUAL DISTORTION OF TEMPORAL ORIENTATION IN CHRONIC SCHIZOPHRENICS
Authors: JOHN LANZKRON, W. WOLFSON
Journal: American Journal of Psychiatry (1958)

The data obtained by systematic investigation have proven the clinical observation of perceptual distortion of temporal orientation in regressed schizophrenics. The fact that the mean stated age was approximately equal to the mean age on admission plus 7 months suggests that it took, on the average, a relatively short time after admission for the temporal orientation to become arrested. It also suggests that apparently hospitalization took place rather late in the course of the disease despite the relative youth of the patients. With increasing age the distortion becomes more conspicuous. These observations dramatically illustrate the known clinical fact of the importance of early treatment before permanent distortion sets in. Since we have not found this phenomenon in other than clinically dull, apathetic, and regressed schizophrenics we are led to interpret its presence as indicative of poor prognosis, and of differential diagnostic value. This preliminary investigation lends credence to Mettler's contention(2). There is reason to believe that prognosis based on the presence or absence of perceptual disorder would be more reliable and indicate results earlier than prognosis that relies mainly on evidence of presence or absence of affect. The psychiatric patient, like any other, is to be studied as a whole personality possessed of structure and organic function as well as psychodynamic mechanisms. It is noteworthy, that even in those chronic regressed schizophrenics, whose behavior and hospital adjustment improved following ECT and/or Thorazine medication, the perceptual distortion of temporal orientation remained unaffected.
Parasitism of the Small Bowel
Authors: William W. Frye
Journal: JAMA (1963)

ABSTRACT THE PARASITIC DISEASES of man which are found primarily in the small bowel are caused by both protozoa and helminths. In this region of the bowel, protozoa are not of major importance, but giardiasis may produce mild symptoms in infants, in whom the infection is more prevalent. Giardia lamblia is found much less frequently in adults, but heavy infections may produce mild but chronic clinical manifestations. This organism is actually the only protozoan parasite found in the small intestine which is of any importance to the clinician.Quinacrine (Atabrine) hydrochloride is highly effective against Giardia lamblia. It should be given by mouth after meals for 5 days. The individual dosage is 0.05 gr twice daily for children 1 to 4 yr of age; 0.1 gr twice daily for those 4 to 8; and 0.1 gr three times a day for persons over 8 yr. Only occasionally is a second course
An encounter with Reynard
Authors: L. Farrell
Journal: BMJ (1997)

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Home visits, within reason, remain a pleasant and sociable part of rural general practice. There is a daily closeness to nature, which I think our colleagues in the cities and towns miss out on; the sense of order, of renewal and change, of rhythm, that gift which, as C S Lewis observed, allows us to celebrate both the joys of newness and of familiarity at the same time. In the teeth of winter the snowdrops, then the crocuses; by March the daffodils; April ushers in the transient fragility of the cherry and magnolia blossoms; early May is the best time, meadows …

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