tbuckley/cabot-search huggingface dataset:
Corrigendum to “Oncogenesis Following Delivery of a Nonprimate Lentiviral Gene Therapy Vector to Fetal and Neonatal Mice”
Authors: Mike Themis, Simon N. Waddington, Manfred Schmidt, Christof von Kalle, Yoahe Wang, Faisal Al-Allaf, Lisa G. Gregory, Megha Nivsarkar, Matthew Themis, Maxine V. Holder, Suzanne M.K. Buckley, Niraja Dighe, Alaine T. Ruthe, Ajay Mistry, Brian Bigger, Ahad Rahim, Tuan H. Nguyen, Didier Trono, Adrian J. Thrasher, Charles Coutelle
Journal: Molecular Therapy (2005)

The authors regret that in Table 2 on page 768, one of the insertion sites of the SMART 2 provirus vector identified using LAM-PCR as present on chromosome 5 positioned 32374 bp upstream of Cyp3a11 was incorrectly assigned to Mouse (tumour) 2 T1. This insertion site should be assigned to an independent mouse not listed in Table 2. This animal had only a single provirus insertion found by Southern and LAM-PCR analyses and should be labeled as mouse 7. The authors regret that in Table 2 on page 768, one of the insertion sites of the SMART 2 provirus vector identified using LAM-PCR as present on chromosome 5 positioned 32374 bp upstream of Cyp3a11 was incorrectly assigned to Mouse (tumour) 2 T1. This insertion site should be assigned to an independent mouse not listed in Table 2. This animal had only a single provirus insertion found by Southern and LAM-PCR analyses and should be labeled as mouse 7. Long-Term Inhibition of HIV-1 Infection in Primary Hematopoietic Cells by Lentiviral Vector Delivery of a Triple Combination of Anti-HIV shRNA, Anti-CCR5 Ribozyme, and a Nucleolar-Localizing TAR DecoyLi et al.Molecular TherapyNovember, 2005In BriefCombinatorial therapies for the treatment of HIV-1 infection have proven to be effective in reducing patient viral loads and slowing the progression to AIDS. We have developed a series of RNA-based inhibitors for use in a gene therapy-based treatment for HIV-1 infection. The transcriptional units have been inserted into the backbone of a replication-defective lentiviral vector capable of transducing a wide array of cell types, including CD34+ hematopoietic progenitor cells. The combinatorial therapeutic RNA vector harbors a U6 Pol III promoter-driven short hairpin RNA (shRNA) targeting the rev and tat mRNAs of HIV-1, a U6 transcribed nucleolar-localizing TAR RNA decoy, and a VA1-derived Pol III cassette that expresses an anti-CCR5 ribozyme. Full-Text PDF Open Archive
Abstract IA15: Adoptive T cell therapy with CAR modified T cells: We have a model A Ford, can we build a Ferrari?
Authors: Renier Brentjens
Journal: Cancer Research (2015)

Abstract Recently published reports support the novel approach of treating cancer with patient derived T cells genetically modified to express artificial T cell receptors, termed chimeric antigen receptors (CARs), targeted to tumor associated antigens. To this end, initial clinical trial outcomes of patients with relapsed B cell acute lymphoblastic leukemia (B-ALL) treated with T cells genetically modified to express a CAR specific to the CD19 antigen demonstrate that this approach is a very promising therapeutic intervention which potentially may dramatically alter the standard of care in this disease. In contrast far more modest clinical responses were seen in patients with relapsed low grade B cell malignancies including chronic lymphocytic leukemia (CLL) and B cell non-Hodgkins lymphomas (NHL). The etiologies of discordant clinical outcomes between B-ALL and CLL/NHL patients treated with CD19 targeted CAR T cells remains a subject of conjecture although the tumor microenvironment is a strong focus for further investigation. To this end, we will present novel data on a next generation of CAR T cells, termed “armored CAR” T cells genetically designed to enhance persistence, anti-tumor efficacy, and an ability to overcome an immune suppressive tumor microenvironment through further genetic modification. Promising preclinical studies utilizing various “armored CAR” T cell approaches and their role in future clinical trials will be discussed as well as the relevance of these findings to the extrapolation of this technology from hematologic tumors to far more prevalent solid tumor malignancies. Note: This abstract was presented as part of the Joint Session: Clinical Science Interactions between Melanoma and Hematologic Malignancies with the AACR Special Conference: Hematologic Malignancies: Translating Discoveries to Novel Therapies held September 20-23, 2014 in Philadelphia, PA. Citation Format: Renier Brentjens. Adoptive T cell therapy with CAR modified T cells: We have a model A Ford, can we build a Ferrari? [abstract]. In: Proceedings of the AACR Special Conference on Advances in Melanoma: From Biology to Therapy; Sep 20-23, 2014; Philadelphia, PA. Philadelphia (PA): AACR; Cancer Res 2015;75(14 Suppl):Abstract nr IA15.
The clinical epidemiology and malignancies associated with Streptococcus bovis biotypes in 506 cases of bloodstream infections
Authors: Juan Corredoira, Imma Grau, Jose F. Garcia-Rodriguez, Pilar Alonso-Garcia, M.J. Garcia-Pais, Ramon Rabuñal, Fernando Garcia-Garrote, Carmen Ardanuy, Amparo Coira, M.J. Lopez-Alvarez, Roman Pallares
Journal: Journal of Infection (2015)
Wax Keratosis in Children's Ears
Authors: J. I. M. Black, R. G. Chaytor
Journal: BMJ (1958)

There is much evidence for the association of adrenal cortical underactivity with hyperthyroidism.Nine hyperthyroid patients had subnormal or low levels of urinary excretion of 17-ketosteroids.The excretion of urinary 17-ketogenic steroids was not reduced.Eight of the patients were treated with corticotrophin in full doses for two to five weeks.Only one patient showed any significant clinical benefit; this was accom- panied by an improvement in all laboratory tests of thyroid overactivity.The ninth patient received treat- ment with prednisone without benefit.The radioiodine studies and urinary steroid estimations were carried out in the laboratories of Professor F. T. G. Prunty, to whom we are grateful.We also thank Dr. R. V.
Self care
Authors: R. Jones
Journal: BMJ (2000)

The iceberg of illness1 is an important concept in understanding the relation between health and illness and one that healthcare systems ignore, Titanic-like, at their peril. The pyramidal iceberg has health at its base and tertiary care at its apex; as individuals develop symptoms they pass upwards through self care, primary care, and secondary care, with specialised services encountering an ever more highly selected patient population. We know surprisingly little about what prompts movement across these interfaces, particularly that between self care and primary care. Initiatives within the NHS to make access to services easier could have profound effects, yet the necessary research is only just being defined.

The movement of patients from self care to primary care and from primary to secondary care determines workload for health services, and relatively small changes at the base of the pyramid can have substantial impacts on demand at higher levels. For example, population screening, ascertainment by …
Folinic acid modulated bolus 5-FU or infusional 5-FU for adjuvant treatment of patients of UICC stage III colon cancer: Preliminary analysis of the PETACC-2-study
Authors: A. Carrato, C. Köhne, L. Bedenne, I. Popov, O. Bouche, E. Gaspar, P. Rougier, U. Schubert, F. Biertz, H. Becker
Journal: Journal of Clinical Oncology (2006)

3563 Background: Patients with stage III colon cancer have a high risk for recurrence. Infusional 5-FU may be more active than bolus application. Methods: From 01/1997 to 03/2004 a total of 1601 patients with UICC stage III colon cancer were randomized to receive the Mayo-Clinic regimen or infusional 5-FU either the weekly high dose AIO regimen, the bi-weekly LV5FU2 regimen or the Spanish weekly high dose TTD-regime. The major aim of this study was to demonstrate a difference of 7 % in the 5 year survival rate in favour of the infusional arm for which a total of 424 events were required. Results: After a median follow-up of 31 months 478 events have occurred. 804 patients received the standard arm and 797 the experimental arm (AIO N=331, EORTC N=92, FFCD N=211, TTD N=163). The median age was 64 years; patients were well distributed according to TNM-category (T3 73 vs. 75%, T4 17 vs. 16%, N2 31 vs. 34%), vascular and lymphatic invasion and grading. The bolus regimen induced a higher rate of grade 3 or 4 leukopenia (7.1% versus 2.0%), stomatitis grade 3 or 4 (9.8% versus 3.3%) or diarrhea grade 3 or 4 (16% vs. 15%). Hand-Foot-Syndrome was more frequent in the experimental arm (4.4% versus 0.4%). There was no difference in the recurrence free survival at 5 years (57% versus 56%; hazard ratio 1.00, 95% CI, 0.84 to 1.21; P=0.9) or overall survival at 5 years 71% versus 72%; hazard ratio 0.91, 95% CI, 0.71 to 1.16; P=0.44). Conclusions: Infusional 5-FU does not improve RFS or overall survival of stage III colon cancer compared to the Mayo regimen but is less toxic. Supported by Deutsche Krebshilfe No significant financial relationships to disclose.
Abstract 18218: In Vitro Characterization of Andexanet Alfa (PRT064445), a Specific fXa Inhibitor Antidote versus Aripazine (PER977), a Non-specific Reversal Agent
Authors: Genmin Lu, Jayaprakash Kotha, Juan M Cardenas, Michael J Herr, Anjali Pandey, John Curnutte, Pamela B Conley, Lisa K Jennings
Journal: Circulation (2014)

New oral fXa inhibitors have been increasingly adopted for VTE or AF treatment in the outpatient setting instead of warfarin. Andexanet alfa (AnXa) is a modified, recombinant human fXa molecule developed as a specific antidote to reverse anticoagulant activity of fXa inhibitors during episodes of serious bleeding or before urgent surgery. PER977, a small molecule under development by Perosphere, Inc., is reported to reverse the effect of a broad range of anticoagulants (fXa and thrombin inhibitors, LMWH). In order to compare AnXa and PER977 mechanisms of action, we studied the in vitro activity of both agents in the presence or absence of fXa inhibitors rivaroxaban, apixaban, edoxaban or enoxaparin. In a buffer system containing purified human fXa with physiologic Ca 2+ (5 mM), AnXa dose-dependently reversed oral fXa inhibitor activity. Reversal activity was not observed for any fXa inhibitor with PER977 over a wide concentration range (≤2 mM). In human plasma, AnXa reversed both direct and ATIII-dependent fXa inhibitors, whereas no reversal effect by PER977 was detected. In the absence of a fXa inhibitor, PER977 potentiated fX activation by fIXa in a buffer system (purified human fX, fIXa and 5mM Ca 2+ ). Similar cofactor activity was observed with polylysine, indicating that PER977 may have properties similar to poly-cationic molecules. Procoagulant activity was observed in human plasma with PER977 at low concentrations (≤100 μM) as measured by clotting (aPTT) or thrombin generation, but inhibition in these assays was seen at higher concentrations ( ~1 mM). PER977 also potentiated human platelet activation as determined by P-selectin expression induced by 10 μM ADP. Platelet aggregation, whole blood hemolysis, or complement activation testing showed no effect with either AnXa or PER977. These data indicate that PER977 does not reverse the anticoagulant activity of a direct or indirect fXa inhibitor in vitro. Its observed in vivo effect on blood loss in animals may not be mediated by direct interaction of PER977 with the inhibitor, but may be in part attributed to an off-target effect, suggested by its potential procoagulant activity. In contrast, AnXa acts as a specific antidote to fXa inhibitors by sequestering them with a defined stoichiometry (1:1 molar ratio).
Efficacy of Antiarrhythmic Drugs in Arrhythmogenic Right Ventricular Cardiomyopathy
Authors: Gregory M. Marcus, David V. Glidden, Bronislava Polonsky, Wojciech Zareba, Lisa M. Smith, David S. Cannom, N.A. Mark Estes, Frank Marcus, Melvin M. Scheinman
Journal: Journal of the American College of Cardiology (2009)
The Biliary System: A Symposium of the NATO Advanced Study Institute.
Authors: W. Taylor
Journal: Annals of Internal Medicine (1966)

The atlas is an eloquent testimony of this kind of evidence on which many of our ideas of gonadal histogenesis have been based in the past, not always perhaps with the success and certainty we would have wished.Sadly it is not yet possible to observe continuously individual cells through successive phases in their life-history and amongst their relatives in their 'house.This form of pictorial time-lapse histology does however emphasize changes in distribution of activity such as shifts in the site of formation of primordial fol- licles.Nevertheless it cannot really analyse events more than one can obtain by glimpses at intervals.The text is clear and concise but it suffers from limitation in the depth of its interpretation for this very reason.The atlas is a valuable record, carefully compiled and accurately recorded and will provide a time-base of events of considerable use to investigators of primate gonads.
The Mechanism and Graphic Registration of the Heart Beat.
Authors: Lewis Thomas
Journal: JAMA (1925)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Clinical comparison of thiothixene and thioridazine in schizophrenic adolescents
Authors: George M. Realmuto, William D. Erickson, Absalom M. Yellin, John H. Hopwood, Lawrence M. Greenberg
Journal: American Journal of Psychiatry (1984)

Of 21 schizophrenic adolescents given thiothixene or thioridazine, many responded poorly or experienced sedation. Because sedation necessitates dose reductions, which limit therapeutic response, for schizophrenic adolescents high-potency neuroleptics may be preferable to the more sedating low-potency drugs.
Vascular Histochemistry. In Relation to the Chemical and Structural Pathology of Cardiovascular Disease.
Authors: Colin Wallace Maitland Adams
Journal: Annals of Internal Medicine (1968)

Dr Torpin has made a side plate into a full and necessarily somewhat repetitive meal.Never- theless, his monograph clearly delineates and focuses attention on the pathogenesis of a group of rare and previously ill-defined clinical entities, namely, foetal anomalies resulting from amnion rupture early or late in gestation.The resulting amniotic or chorionic strands may cause diverse deformities such as intra-uterine amputations, interruption of the umbilical circulation and facial clefts due to traction from swallowed strands which have remained peripherally fixed to the walls of the chorionic vesicle.The foetal head, thus relatively immobilized, frequently becomes attached to the amnion-denuded placental surface.Finally, clubbing of the extremities consequent upon transient oligohydramnios resulting from amnion rupture may occur.A number of interesting incidental facts emerge from this comprehensive study, perhaps the most intriguing from the embryologists point of view are two reports of intra-uterine foetal survival following amputation of the head.In one case the 2000 g foetus survived without a head until eight days before birth-nature's experiment which is still in scientific vogue when surgically induced in rabbits!This is primarily a commuting clinicians book, it uinderlines the importance of examining the morphology of the foetal membranes after delivery and suggests means of doing so.
Obesity and psychoanalysis
Authors: C Rand, A J Stunkard
Journal: American Journal of Psychiatry (1978)

Seventy-two psychoanalysts collected information on 84 obese patients and on a control sample of 63 of their patients of normal weight. Despite the fact that obesity was the chief complaint of only 6% of the obese patients, weight losses at 42 months of psychoanalytic treatment compared favorably with those after traditional medical efforts: 47% of the obese psychoanalytic patients lost more than 9 kg, and 19% lost more than 18 kg. There was also a striking decrease in the percentage of obese patients suffering from body image disparagement--from 44% to 12%, an unexpectedly good result for this chronic and intractable disorder.
Impaired replication of protease inhibitor-resistant HIV-1 in human thymus
Authors: Cheryl A. Stoddart, Teri J. Liegler, Fabrizio Mammano, Valerie D. Linquist-Stepps, Matthew S. Hayden, Steven G. Deeks, Robert M. Grant, François Clavel, Joseph M. McCune
Journal: Nature Medicine (2001)
Abstract 11612: Serial Changes in Specific Biomarkers Reflect Cardiac Resynchronization Therapy Response: Results From the SMART-AV Trial
Authors: Sony Jacob, Dawn A Morales, Timothy E Meyer, Craig M Stolen, Jennifer E Van Eyk, Michael R Gold, Suneet Mittal, Nicholas Wold, John F Beshai, Kenneth M Stein, Kenneth A Ellenbogen, Francis G Spinale
Journal: Circulation (2014)

Background:  Early identification of a favorable cardiac resynchronization therapy (CRT) response holds great clinical import. These studies often utilized a single biomarker or were performed at one point in time. The present study utilized an innovative approach whereby a panel of biomarkers were quantified in patients prior to CRT implant (Baseline) and then at 3 and 6 months post-CRT in a robust group of patients whereby CRT response had also been pre-specified.   Methods/Results:  Plasma was collected from patients (SMART-AV trial), and a positive CRT response was pre-specified as a ≥15 mL reduction in LV end-systolic volume at 6 months post-CRT (Responders:n=390/Non-Responders:n=388). Through initial cohort testing and multivariate modeling, serial measures of a 12 biomarker cassette was selected using high sensitivity multiplex profiling, which consisted of C-reactive protein, soluble glycoprotein 130, soluble interleukin-2 receptor, soluble tumor necrosis factor receptor-II, interferon gamma, N-terminal brain natriuretic peptide (NT-proBNP), soluble suppressor of tumorgenicity-2 (sST-2), matrix metalloproteinases-2 and -9 (MMP-2, MMP-9), and tissue inhibitors of MMP (TIMP-1, -2, -4). Analysis of variance (ANOVA) for repeated measures identified that NT-proBNP, sST-2, and MMP-2 changed across time following CRT (by ANOVA, p   Conclusion:  The unique findings from this study identified that time dependent changes in a specific biomarker signature occur early in those patients likely to respond favorably to CRT, and as such, may be of potential utility for point of care testing and integration into the CRT evaluation algorithm.
A Novel, Myeloid Transcription Factor, C/EBPε, Is Upregulated During Granulocytic, But Not Monocytic, Differentiation
Authors: Roberta Morosetti, Dorothy J. Park, Alexey M. Chumakov, Isabelle Grillier, Masaaki Shiohara, Adrian F. Gombart, Tsuyoshi Nakamaki, Kenneth Weinberg, H. Phillip Koeffler
Journal: Blood (1997)
IgMs produced by two acquired immune deficiency syndrome lymphoma cell lines: Ig binding specificity and VH-gene putative somatic mutation analysis [published erratum appears in Blood 1994 Aug 1;84(3):995]
Authors: VL Ng, MH Hurt, CL Fein, F Khayam-Bashi, J Marsh, WM Nunes, LW McPhaul, E Feigal, P Nelson, BG Herndier
Journal: Blood (1994)
T-lymphocyte production of macrophage inflammatory protein-1α is critical to the recruitment of CD8+ T cells to the liver, lung, and spleen during graft-versus-host disease
Authors: Jonathan S. Serody, Susan E. Burkett, Angela Panoskaltsis-Mortari, Judith Ng-Cashin, Eileen McMahon, Glenn K. Matsushima, Sergio A. Lira, Donald N. Cook, Bruce R. Blazar
Journal: Blood (2000)
Abstract 16765: Cyclophilin-D: A Regulator of Mitochondrial Gene Expression
Authors: Jeejabai Radhakrishnan, Raúl J Gazmuri
Journal: Circulation (2014)

Background: Cyclophilin-D (Cyp-D) is a peptidyl-prolyl isomerase resident in the mitochondrial matrix; and like other cyclophilins it can catalyze conformational changes of proteins. Cyp-D is best known for its role in lowering the threshold for opening of the mitochondrial permeability transition pore. However, a serendipitous observation by us, whereby Cyp-D silencing halted cell proliferation, and reports by others that Cyp-D could interact with nuclear transcription factors that have translocated to mitochondria, prompted us to hypothesize that Cyp-D could interact with native mitochondrial transcription factors (mTFs; TFB1M, TFB2M, and TFAM) and therefore be a key regulator of mitochondrial gene expression. Given that all 13 mitochondrial-encoded proteins are components of respiratory chain complexes, our hypothesis would support a central role of Cyp-D in cellular respiration. Methods and Results: We first analyzed the interaction of Cyp-D with mTFs by co-immunoprecipitation (co-IP) and reverse co-IP after transfection of constructs expressing FLAG-tagged Cyp-D and V5-tagged mTFs in HEK 293T cells, showing specific interactions of Cyp-D with TFB1M and with TFB2M but not with TFAM. We then quantitated by real time qPCR mitochondrial-encoded respiratory chain transcripts in HEK 293T cells at day 8 post-infection with lentiviruses encoding shRNA against Cyp-D, showing striking reductions in transcripts ND1, COX1, and ATP6 (initiated from the heavy strand promoter 2) but not in transcript ND6 (initiated from the light strand promoter). Finally, we measured cellular oxygen consumption, also on post-infection day 8, and found it reduced without improvement after uncoupling of electron transport from ATP synthesis with FCCP, consistent with the aforementioned reductions in mitochondrial transcripts of electron transport complexes. At the same time, mitochondrial mass, expression of nuclear genes, and cell viability were all preserved. Conclusion: In HEK 293 T cells, Cyp-D is required for mitochondrial gene expression modulating transcription possibly through the heavy strand promoter 2 suggesting a novel Cyp-D function as regulator of oxidative phosphorylation and thus of the fundamental process of cellular respiration.
Vaccination of patients with chronic myelogenous leukemia with bcr-abl oncogene breakpoint fusion peptides generates specific immune responses
Authors: J. Pinilla-Ibarz, K. Cathcart, T. Korontsvit, S. Soignet, M. Bocchia, J. Caggiano, L. Lai, J. Jimenez, J. Kolitz, D. A. Scheinberg
Journal: Blood (2000)