tbuckley/cabot-search huggingface dataset:
Time-Updated Systolic Blood Pressure and the Progression of Chronic Kidney Disease
Authors: Amanda H. Anderson, Wei Yang, Raymond R. Townsend, Qiang Pan, Glenn M. Chertow, John W. Kusek, Jeanne Charleston, Jiang He, RadhaKrishna Kallem, James P. Lash, Edgar R. Miller, Mahboob Rahman, Susan Steigerwalt, Matthew Weir, Jackson T. Wright, Harold I. Feldman
Journal: Annals of Internal Medicine (2015)

Previous reports of the longitudinal association between achieved blood pressure (BP) and end-stage renal disease (ESRD) among patients with chronic kidney disease (CKD) have not incorporated time-updated BP with appropriate covariate adjustment.
Epidemiological study of influenza B in Shanghai during the 2009–2014 seasons: implications for influenza vaccination strategy
Authors: B. Zhao, S. Qin, Z. Teng, J. Chen, X. Yu, Y. Gao, J. Shen, X. Cui, M. Zeng, X. Zhang
Journal: Clinical Microbiology and Infection (2015)

A new quadrivalent influenza vaccine has been available for influenza B, which can pose a significant global health burden. Shanghai has the highest GDP and largest metropolitan population in China. To understand the impact of influenza B in Shanghai in terms of age-related incidence and relative prevalence compared with other subtypes, we conducted this retrospective epidemiological study of influenza B in the 2009–2014 seasons. A total of 71 354 outpatients with influenza-like illness were included, and both lineages of influenza B and subtypes of influenza A were identified using real-time RT-PCR. The antigenic characteristics of influenza B isolates were analysed by sequencing and reciprocal haemagglutinin inhibition assay. On average, 33.45% of influenza strains were influenza B, and 40.20% of strains isolated from children were influenza B. The incidence of influenza B was highest (12.52 per 100 people with influenza-like illness) in children ages 6–17 years and usually peaked in this age group at the early stage of an influenza B epidemic. Overall, both matched and mismatched influenza B strains co-circulated in Shanghai annually, and 44.57% of the circulating influenza B belonged to the opposite lineage of the vaccine strains. We concluded that influenza B has caused a substantial impact in Shanghai and that school-aged children play a key role in the transmission of influenza B. Hence, it may be beneficial to prioritize influenza vaccination for school-aged children to mitigate the outbreaks of influenza B.
Efficacy of gamma vascular brachytherapy for ostial versus nonostial in stent restenotic lesions
Authors: Costantino O. Costantini, Alexandra J. Lansky, Roxana Mehran, Martin Fahy, Kazuyuki Shirai, Nishi Dave, Gregg W. Stone, George Dangas, Martin B. Leon
Journal: Journal of the American College of Cardiology (2002)
Efficacy of Topical Antifungal Agents in the Treatment of Dermatophytosis—Reply
Authors: Inajara Rotta, Cassyano Januário Correr
Journal: JAMA Dermatology (2013)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Dermatology HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Dermatology journal
Patterns of failure and predictors of outcome in cutaneous malignant melanoma of the scalp
Authors: Breanne E. Terakedis, Christopher J. Anker, Sancy A. Leachman, Robert H.I. Andtbacka, Glen M. Bowen, William T. Sause, Kenneth F. Grossmann, Tawnya L. Bowles, R. Dirk Noyes, Ying J. Hitchcock, Kenneth M. Boucher, Dennis C. Shrieve
Journal: Journal of the American Academy of Dermatology (2013)
The soluble extracellular domain of EphB4 (sEphB4) antagonizes EphB4-EphrinB2 interaction, modulates angiogenesis, and inhibits tumor growth
Authors: Nathalie Kertesz, Valery Krasnoperov, Ramachandra Reddy, Lucy Leshanski, S. Ram Kumar, Sergey Zozulya, Parkash S. Gill
Journal: Blood (2005)
Seizure Disorders and Pregnancy
Authors: Donald J. Dalessio
Journal: New England Journal of Medicine (1985)

THE objectives of treatment of the pregnant woman with epilepsy are to maintain the patient in a seizure-free state while minimizing when possible the adverse effects of the seizure disorder on the course of the pregnancy and the possible teratogenetic effects of some anticonvulsant agents on the fetus.Unless otherwise specifically indicated, the discussion in this paper will focus on primary generalized seizures (tonic–clonic or grand mal), including partial complex seizures that become generalized.Seizure Frequency in PregnancyPregnant women with epilepsy can be divided into two categories: those identified as having epilepsy before their child was conceived and in . . .
Downregulation of a disintegrin and metalloproteinase 33 by IFN-γ in human airway smooth muscle cells
Authors: Isao Ito, Johanne D. Laporte, Pierre O. Fiset, Kazuhisa Asai, Yasuhiro Yamauchi, James G. Martin, Qutayba Hamid
Journal: Journal of Allergy and Clinical Immunology (2006)
Simultaneous expression of Borrelia OspA and OspC and IgM response in cerebrospinal fluid in early neurologic Lyme disease.
Authors: S E Schutzer, P K Coyle, L B Krupp, Z Deng, A L Belman, R Dattwyler, B J Luft
Journal: Journal of Clinical Investigation (1997)

Lyme disease is the major tick-borne disease, caused by Borrelia burgdorferi (Bb). Neurological involvement is common in all stages. In vivo expression of Bb antigens (Ags) and the immune response to them has not been well investigated in the cerebrospinal fluid (CSF). Upregulation of outer surface protein (Osp) C and concomitant downregulation of OspA before tick inoculation of the spirochete has been reported in skin and blood in animals. CSF OspA Ag in early disease suggests otherwise in CSF. Early Ag expression and IgM response in human CSF was investigated here. Paired CSF and serum was collected from 16 early, predominantly erythema migrans Lyme disease patients with neurologic problems, 13 late Lyme disease patients, and 19 other neurologic disease (OND) controls. Samples were examined for IgM reactivity to recombinant Bb-specific Osps using ELISA and immunoblot. Of 12 early Lyme disease patients with neurologic involvement with both CSF and serum IgM against OspC, 7 (58%) had IgM to OspA (n = 5) or OspB (n = 2) that was restricted to the CSF, not serum. Overall, 12 of 16 (75%) of these early Lyme disease patients with neurologic involvement had CSF and serum IgM against OspC. Only 3 of 13 (23%) late Lyme disease patients and none of 19 OND controls had CSF IgM directed against OspC. In conclusion, in CSF, OspC and OspA can be coexpressed, and IgM response to them occurs in early Lyme disease patients with neurologic involvement. This biologic finding may also provide a discriminating marker for CNS infection in Lyme disease.
The Allure of the Permanent Cure
Authors: Robert L. Martensen
Journal: JAMA (1995)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Genetic loss of SH2B3 in acute lymphoblastic leukemia
Authors: Arianne Perez-Garcia, Alberto Ambesi-Impiombato, Michael Hadler, Isaura Rigo, Charles A. LeDuc, Kara Kelly, Chaim Jalas, Elisabeth Paietta, Janis Racevskis, Jacob M. Rowe, Martin S. Tallman, Maddalena Paganin, Giuseppe Basso, Wei Tong, Wendy K. Chung, Adolfo A. Ferrando
Journal: Blood (2013)
Dual regulation of glycogen metabolism by insulin and insulin-like growth factors in human hepatoma cells (HEP-G2). Analysis with an anti-receptor monoclonal antibody.
Authors: E J Verspohl, R A Roth, R Vigneri, I D Goldfine
Journal: Journal of Clinical Investigation (1984)

Insulin and the insulinlike growth factors (IGF-I and IGF-II) are members of a family of hormones that regulate the metabolism and growth of many tissues. Cultured HEP-G2 cells (a minimal deviation human hepatoma) have insulin receptors and respond to insulin by increasing their glycogen metabolism. In the present study with HEP-G2 cells, we used 125I-labeled insulin, IGF-I, and IGF-II to identify distinct receptors for each hormone by competition-inhibition studies. Unlabeled insulin was able to inhibit 125I-IGF-I binding but not 125I-IGF-II binding. A mouse monoclonal antibody to the human insulin receptor that inhibits insulin binding and blocks insulin action inhibited 75% of 125I-insulin binding, but inhibited neither 125I-IGF-I nor 125I-IGF-II binding. When glycogen metabolism was studied, insulin stimulated [3H]glucose incorporation into glycogen in a biphasic manner; one phase that was 20-30% of the maximal response occurred over 1-100 pM, and the other phase occurred over 100 pM-100 nM. The anti-receptor monoclonal antibody inhibited the first phase of insulin stimulation but not the second. Both IGF-I and IGF-II stimulated [3H]glucose incorporation over the range of 10 pM-10 nM; IGF-I was three to fivefold more potent. The monoclonal antibody, however, was without effect on IGF regulation of glycogen metabolism. Therefore, these studies indicate that insulin as well as the IGFs at physiological concentrations regulate glycogen metabolism in HEP-G2 cells. Moreover, this regulation of glycogen metabolism is mediated by both the insulin receptor and the IGF receptors.
Expanding the Boundaries of Medicine
Authors: William H. Foege
Journal: JAMA (1991)

What is medicine's greatest gift to the world? It is tempting to list vaccines, antibiotics, or procedures, but these individual breakthroughs are simply pieces of a much larger contribution. Medicine's greatest gift to the world is mounting evidence that our world is not a fatalistic one. We can have a positive impact on our own mortality. The average American has seen life expectancy increase by over 7 hours for every day that has elapsed since January 1,1990. As medicine frees people from unnecessary suffering, compromised quality of life, and early death, it reaffirms a belief in a cause-and-effect world. It makes it possible to plan a rational future. High death rates for infants and children before the 20th century were thought by many to be due to natural laws. Medicine contradicts that fatalism daily, allowing children to live to school age, to marriage, and, finally, to the birth of their
HYPERCHOLESTEROLEMIA AWARENESS, TREATMENT AND CONTROL IN HIGH CARDIOVASCULAR RISK SUBJECTS IN INDIA: A POPULATION-BASED STUDY
Authors: Rajeev Gupta, Krishnakumar Sharma, Soneil Guptha, Vijay Achari, Anil Bhansali, Prakash Deedwania
Journal: Journal of the American College of Cardiology (2013)
General practitioners' referrals to specialist outpatient clinics. I. Why general practitioners refer patients to specialist outpatient clinics.
Authors: A. Coulter, A. Noone, M. Goldacre
Journal: BMJ (1989)

There has been much concern about the wide variations in general practitioners' referral rates and the consequent implications for cost and quality of care. This has led to a call to evaluate the appropriateness and effectiveness of referrals. A collaborative audit of referrals to outpatient clinics was conducted by 127 general practitioners in 33 practices in the Oxford region. Records were kept of 18,754 referrals, which included data on diagnoses and reasons for referral. Overall, 6553 (35.4%) of the referrals were for particular treatments or operations and a further 6475 (34.9%) were for specific investigation or diagnosis. Advice on management was the main reason for referral in 2656 (14.3%) cases, and in 1719 (9.3%) cases the general practitioners wanted the consultants to take over managing their patients. Reassurance of either the general practitioner or the patient was recorded as the main reason in only 762 (4.1%) referrals. There seems to be scope for rationalising the referral process. A programme with three stages for evaluating referrals to outpatient clinics is recommended.
FRACTIONAL FLOW RESERVE AND THE INSTANT WAVE–FREE RATIO HAVE EQUIVALENT AGREEMENT WITH FLOW–BASED INDICES ACROSS THE ENTIRE SPECTRUM OF STENOSIS SEVERITY RESULTS OF THE CLARIFY STUDY RESULTS OF CLARIFY (THE CLASSIFICATION ACCURACY OF PRESSURE–ONLY RATIOS AGAINST INDICES USING FLOW STUDY)
Authors: Sayan Sen, Justin Davies, Sukhjinder Nijjer, Ricardo Petraco da Cunha, Rodney Foale, Iqbal Malik, Ghada Mikhail, Kal Asrress, Alun Hughes, Javier Escaned, Darrel Francis, Simon Redwood, Jamil Mayet
Journal: Journal of the American College of Cardiology (2013)
On training tomorrow's doctors: the Newcastle curriculum revised and reconstructed.
Authors: J N Walton
Journal: BMJ (1977)

of financial constraint, the problems of providing a medical training that is balanced yet comprehensive, scientifically adequate yet clinically relevant, and intellectually challenging without stifling initiative presents increasing problems.For- tunately, the British medical schools, despite current unease in the National Health Service, continue to receive far more applications from academically outstanding and well-motivated young men and women than they can possibly accept.Without question those students who are admitted usually have the intellectual capacity, application, and dedication to enable them to cope with whatever course we offer them, however demanding it may be.This paper aims to show how medical education in Newcastle has been shaped in the last 15 years and to describe some recent changes.Growth in the medical school In 1971, when I was appointed dean of medicine, we accepted 100 students a year into the second year of medical curriculum, 95 usually being admitted direct from school and five coming from on 1 August
Evidence for the mixing of residue in the human gut.
Authors: H S Wiggins, J H Cummings
Journal: Gut (1976)

Mixing the residue in the gut has been studied in 24 normal subjects using five different types of radio-opaque pellets. By giving single doses of different pellets to the subjects on three successive days and measuring their appearances in the stool by radiographs evidence of mixing was found in 83% of studies. Mean transit time (MTT) of markers through the gut was measured from the single dose studies (MTT-S) and also by giving the pellets to subjects continuously with each meal (MTT-C). By comparing MTT-C with MTT-S evidence was found for a mixing pool with exponential decay. The turnover time of this pool was estimated as about 30% of the total MTT.
Germline Epigenetic Regulation of &lt;emph type="ital"&gt;KILLIN&lt;/emph&gt; in Cowden and Cowden-like Syndrome
Authors: Kristi L. Bennett
Journal: JAMA (2010)

Germline loss-of-function phosphatase and tensin homolog gene (PTEN) mutations cause 80% of Cowden syndrome, a rare autosomal-dominant disorder (1 in 200,000 live births), characterized by high risks of breast, thyroid, and other cancers. A large heterogeneous group of individuals with Cowden-like syndrome, who have various combinations of Cowden syndrome features but who do not meet Cowden syndrome diagnostic criteria, have PTEN mutations less than 10% of the time, making molecular diagnosis, prediction, genetic counseling, and risk management challenging. Other mechanisms of loss of function such as hypermethylation, which should result in underexpression of PTEN or of KILLIN, a novel tumor suppressor transcribed in the opposite direction, may account for the remainder of Cowden syndrome and Cowden-like syndrome.To determine whether germline methylation is found in Cowden syndrome or Cowden-like syndrome in individuals lacking germline PTEN mutations.Nucleic acids from prospective nested series of 123 patients with Cowden syndrome or Cowden-like syndrome and 50 unaffected individuals without PTEN variants were analyzed for germline methylation and expression of PTEN and KILLIN at the Cleveland Clinic, August 2008-June 2010. Prevalence of component cancers between groups was compared using the Fisher exact test.Frequency of germline methylation in PTEN mutation-negative Cowden syndrome and Cowden syndrome-like individuals. Prevalence of component cancers in methylation-positive and PTEN mutation-positive individuals.Of 123 patients with Cowden syndrome or Cowden-like syndrome, 45 (37%; 95% confidence interval [CI], 29%-45%) showed hypermethylation upstream of PTEN but no transcriptional repression. The germline methylation was found to transcriptionally down-regulate KILLIN by 250-fold (95% CI, 45-14 286; P = .007) and exclusively disrupted TP53 activation of KILLIN by 30% (95% CI, 7%-45%; P = .008). Demethylation treatment increased only KILLIN expression 4.88-fold (95% CI, 1.4-18.1; P = .05). Individuals with KILLIN -promoter methylation had a 3-fold increased prevalence of breast cancer (35/42 vs 24/64; P < .0001) and a greater than 2-fold increase of kidney cancer (4/45 vs 6/155; P = .004) over individuals with germline PTEN mutations.Germline KILLIN methylation is common among patients with Cowden syndrome or Cowden-like syndrome and is associated with increased risks of breast and renal cancer over PTEN mutation-positive individuals. These observations need to be replicated.
Remission of Diabetes by β-Cell Regeneration in Diabetic Mice Treated With a Recombinant Adenovirus Expressing Betacellulin
Authors: Seungjin Shin, Na Li, Naoya Kobayashi, Ji-Won Yoon, Hee-Sook Jun
Journal: Molecular Therapy (2008)

Type 1 diabetes results from destruction of the majority of the pancreatic β cells by β cell–specific autoimmune responses; therefore, expansion of the β-cell mass in vivo Is a possible approach to its treatment. Betacellulin (BTC) is known to promote β-cell growth and differentiation. We investigated whether transient, constitutive expression, and secretion of BTC would regenerate sufficient numbers of pancreatic β cells to restore normoglycemia in diabetic animals. We constructed a recombinant adenoviral vector (rAd-BTC) containing the cytomegalovirus promoter/enhancer, β-globin chimeric intron, and albumin leader sequence to facilitate secretion, followed by BTC (1-80) complementary DNA (cDNA) encoding mature BTC. A single intravenous (IV) administration of rAd-BTC resulted in complete remission of streptozotocin (STZ)-induced diabetes within 2 weeks in mice. The mice remained normoglycemic for >100 days; glucose tolerance tests showed kinetics similar to normal, nondiabetic mice. Pancreatic insulin content, β-cell mass, and serum insulin levels in rAd-BTC-treated mice were significantly higher than in the controls. Treatment of autoimmune diabetic mice with rAd-BTC in combination with an immune suppressor resulted in remission of diabetes. We conclude that transient expression of BTC by rAd-BTC administration results in prolonged remission of diabetes in mice, by the regeneration of sufficient numbers of β cells in the pancreas. Type 1 diabetes results from destruction of the majority of the pancreatic β cells by β cell–specific autoimmune responses; therefore, expansion of the β-cell mass in vivo Is a possible approach to its treatment. Betacellulin (BTC) is known to promote β-cell growth and differentiation. We investigated whether transient, constitutive expression, and secretion of BTC would regenerate sufficient numbers of pancreatic β cells to restore normoglycemia in diabetic animals. We constructed a recombinant adenoviral vector (rAd-BTC) containing the cytomegalovirus promoter/enhancer, β-globin chimeric intron, and albumin leader sequence to facilitate secretion, followed by BTC (1-80) complementary DNA (cDNA) encoding mature BTC. A single intravenous (IV) administration of rAd-BTC resulted in complete remission of streptozotocin (STZ)-induced diabetes within 2 weeks in mice. The mice remained normoglycemic for >100 days; glucose tolerance tests showed kinetics similar to normal, nondiabetic mice. Pancreatic insulin content, β-cell mass, and serum insulin levels in rAd-BTC-treated mice were significantly higher than in the controls. Treatment of autoimmune diabetic mice with rAd-BTC in combination with an immune suppressor resulted in remission of diabetes. We conclude that transient expression of BTC by rAd-BTC administration results in prolonged remission of diabetes in mice, by the regeneration of sufficient numbers of β cells in the pancreas.
Management Setting of Obstructive Sleep Apnea—Reply
Authors: Ching Li Chai-Coetzer, Nick A. Antic, R. Doug McEvoy
Journal: JAMA (2013)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal