SICKLE CELL-HEMOGLOBIN C DISEASE
Authors: E F HAYS, R L ENGLE
Journal: Annals of Internal Medicine (1955)

Case Reports1 August 1955SICKLE CELL-HEMOGLOBIN C DISEASEESTHER FINCHER HAYS, M.D., RALPH L. ENGLE JR., M.D.ESTHER FINCHER HAYS, M.D.Search for more papers by this author, RALPH L. ENGLE JR., M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-43-2-412 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptRecent studies have shown that sickle hemoglobin can be differentiated electrophoretically from normal adult hemoglobin,1, 2and have also demonstrated the existence of a new abnormal hemoglobin, which has been designated as hemoglobin C.3, 4It has been shown further that hemoglobin C, like sickle cell hemoglobin, is a hereditary abnormality. Its inheritance is as a Mendelian dominant. Homozygous hemoglobin C produces a mild hemolytic anemia and an increase in target cells in the peripheral blood. Cases have been described by Spaet, Alway and Ward,9Ranney, Larsen and McCormack,6and Watson.10The trait for hemoglobin C produces no symptoms. All...Bibliography1. PaulingItanoSingerWells LHASJIC: Sickle cell anemia, a molecular disease, Science 110: 543, 1949. CrossrefMedlineGoogle Scholar2. SingerFisher KB: Studies on abnormal hemoglobins. VI. Electrophoretic demonstration of type S hemoglobin in erythrocytes incapable of showing sickle cell phenomenon, Blood 8: 270, 1953. CrossrefMedlineGoogle Scholar3. KaplanZuelzerNeel EWWJV: A new inherited anomaly of hemoglobin and its interaction with sickle cell hemoglobin, Blood 6: 1240, 1951. CrossrefMedlineGoogle Scholar4. NeelKaplanZuelzer JVEWW: Further studies of hemoglobin C, Blood 8: 724, 1953. CrossrefMedlineGoogle Scholar5. SmithConley EWCL: Filter paper electrophoresis of human hemoglobins with special reference to the incidence and clinical significance of hemoglobin C, Bull. Johns Hopkins Hosp. 93: 94, 1953. MedlineGoogle Scholar6. RanneyLarsenMcCormack HMDLGH: Some clinical, biochemical and genetic observations on hemoglobin C, J. Clin. Investigation 32: 1277, 1953. CrossrefMedlineGoogle Scholar7. Wintrobe MM: Clinical hematology, 3d Ed., 1951, Lea and Febiger, Philadelphia, p. 613. Google Scholar8. EhrenpreisSchwinger BHN: Sickle cell anemia, Am. J. Roentgenol. 68: 28, 1952. Google Scholar9. SpaetAlwayWard THRHG: Homozygous type C hemoglobin, Pediatrics 12: 483, 1953. MedlineGoogle Scholar10. Watson RJ: The hereditary anemias, Bull. New York Acad. Med. 30: 106, 1954. MedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: New York, N. Y.*Received for publication June 29, 1954.From the Department of Medicine, The New York Hospital Cornell Medical Center.†Present address: University of California Atomic Energy Project, Los Angeles, Calif.‡Markle Scholar Medical Science. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited bySevere Proliferative Retinopathy as the Only Sign of Sickle Cell Hemoglobin C DiseaseALLELISM, NON-ALLELISM, AND GENETIC COMPOUNDS AMONG THE MUCOPOLYSACCHARIDOSESClinical and hematological manifestations of hemoglobin CS disease in childrenPulmonary Infarction and Atrophy of the Spleen Associated with Sickle-Cell Hemoglobin C Disease 1 August 1955Volume 43, Issue 2Page: 412-418KeywordsAnemiaBlood cellsCellsGeneticsHemoglobinHemolytic anemiaHospital medicineSickle cell hemoglobin ePublished: 1 December 2008 Issue Published: 1 August 1955 PDF downloadLoading ...