tbuckley/cabot-search huggingface dataset:
Child abuse and the physician
Authors: A. R. Holder
Journal: JAMA (1972)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Five-Year Follow-Up of "Total Therapy" of Childhood Lymphocytic Leukemia
Authors: Donald Pinkel
Journal: JAMA (1971)

Between 1962 and 1965, combination therapy with multiple agents was administered to 37 children with acute lymphocytic leukemia (ALL). After five years, eight children continue to survive. Seven of the eight children are in complete remission, and have not been receiving any therapy for 1 1/2 to 3 1/2 years. The results indicate that a significant five-year-cure rate of childhood ALL is an attainable goal with multiple-agent therapy.
A Rare Case of Ectopic Adrenocorticotropic Hormone Syndrome Caused by a Metastatic Neuroendocrine Tumor of the Pancreas Detected by 68Ga-DOTANOC and 18F-FDG PET/CT
Authors: Giorgio Treglia, Enrica Salomone, Gianluigi Petrone, Andrea Giaccari, Guido Rindi, Vittoria Rufini
Journal: Clinical Nuclear Medicine (2013)

We report a rare case of ectopic adrenocorticotropic hormone (ACTH) syndrome caused by a metastatic neuroendocrine tumor (NET) of the pancreas detected by PET/CT using different tracers. A 43-year-old female patient with Cushing syndrome (CS) by suspected ectopic ACTH secretion underwent a 68Ga-DOTANOC and a 18F-FDG PET/CT. Both these functional imaging techniques revealed increased tracer uptake in a pancreatic mass and multiple liver metastases. Histology showed the presence of a mildly differentiated pancreatic NET. 68Ga-DOTANOC PET/CT may be a useful functional imaging method, complementary to 18F-FDG PET/CT, in detecting ACTH-secreting pancreatic NETs.
Abstract PD06-08: Strong prognostic concordance between Ki67 and binary, but not multi-level gene expression signatures
Authors: NP Tobin, LS Lindström, JW Carlson, J Bergh, K Wennmalm
Journal: Cancer Research (2012)

Abstract Background: Several proliferation-related gene signatures have been proposed to aid breast cancer management by providing better prognostic and therapy predictive information on a patient-by-patient basis. It is unclear however, whether a less demanding assessment of cell division rate (as determined by Ki67 expression) can function in place of gene profiling. Methods: Agreement between literature-, distribution-based, as well as signature-derived threshold values for Ki67, relative to the genomic grade index (GGI), the 70-gene signature, the p53 signature, the recurrence score (RS), and the molecular subtype models of Sorlie, Hu, and Parker was investigated in a representative set of 253 breast cancers with 25 years follow up. Relevance for breast cancer specific survival was assessed for contrast groups, and in uni- and multivariate Cox models. Results: Our broad approach identified Ki67 cutoffs in the range of 10%–20%. With optimum signature-reproducing cutoffs, similarity in classification of individual tumors was high for GGI (81%), the 70-gene (78%), and the p53 (82%) signatures, but lower for the recurrence score (68%), Sorlie (68%), Parker (67%) and Hu (68%) signatures. Consistent with strong agreement, no prognostic superiority was noted for Ki67 vs. the binary GGI, 70-gene and p53 signatures respectively, in multivariate analyses. In contrast, Ki67-independent prognostic capacity could be demonstrated for RS and molecular subtypes according to Sorlie, Parker and Hu (Table 1). Conclusions: The added prognostic value of binary proliferation-related gene signatures appears limited for Ki67-assessed breast cancers. More complex, multi-level descriptions seem to have a greater potential in pinpointing the outcome heterogeneity in breast cancer. We aim to validate our findings in a second cohort of 159 breast cancer patients with over 15 years of clinical follow up. Citation Information: Cancer Res 2012;72(24 Suppl):Abstract nr PD06-08.
DIPHTHERIA IN THE TROPICS: A SUBCLINICAL DISEASE IN NEGROES
Authors: G. Kinneard
Journal: BMJ (1935)

Though diphtheria is considered to be uncommon in the Tropics, it does occur in tropical latitudes every year.The following table gives the evidence of this disease as recently reported in a supplement to the Tropical Diseases Bulletin.'It covers 1931, which is probably quite a representative year.
Characterization of Phthalate Exposure among Pregnant Women Assessed by Repeat Air and Urine Samples
Authors: Jennifer J. Adibi, Robin M. Whyatt, Paige L. Williams, Antonia M. Calafat, David Camann, Robert Herrick, Heather Nelson, Hari K. Bhat, Frederica P. Perera, Manori J. Silva, Russ Hauser
Journal: Environmental Health Perspectives (2008)

Although urinary concentrations of phthalate metabolites are frequently used as biomarkers in epidemiologic studies, variability during pregnancy has not been characterized.We measured phthalate metabolite concentrations in spot urine samples collected from 246 pregnant Dominican and African-American women. Twenty-eight women had repeat urine samples collected over a 6-week period. We also analyzed 48-hr personal air samples (n = 96 women) and repeated indoor air samples (n = 32 homes) for five phthalate diesters. Mixed-effects models were fit to evaluate reproducibility via intraclass correlation coefficients (ICC). We evaluated the sensitivity and specificity of using a single specimen versus repeat samples to classify a woman's exposure in the low or high category.Phthalates were detected in 85-100% of air and urine samples. ICCs for the unadjusted urinary metabolite concentrations ranged from 0.30 for mono-ethyl phthalate to 0.66 for monobenzyl phthalate. For indoor air, ICCs ranged from 0.48 [di-2-ethylhexyl phthalate (DEHP)] to 0.83 [butylbenzyl phthalate (BBzP)]. Air levels of phthalate diesters correlated with their respective urinary metabolite concentrations for BBzP (r = 0.71), di-isobutyl phthalate (r = 0.44), and diethyl phthalate (DEP; r = 0.39). In women sampled late in pregnancy, specific gravity appeared to be more effective than creatinine in adjusting for urine dilution.Urinary concentrations of DEP and DEHP metabolites in pregnant women showed lower reproducibility than metabolites for di-n-butyl phthalate and BBzP. A single indoor air sample may be sufficient to characterize phthalate exposure in the home, whereas urinary phthalate biomarkers should be sampled longitudinally during pregnancy to minimize exposure misclassification.
Deaths Associated With Yellow Fever Experiments-Reply
Authors: William H. Crosby
Journal: JAMA (1983)

<h3>In Reply.—</h3> Dr Olson quotes from our article that "none of these volunteers died." The statement is correct. The experiments carried out on Walter Reed's protocol commenced Dec 5, 1900. On Jan 31, 1901, when Reed wrote of his melancholia to Surgeon General Sternberg, his last experimental subject had been infected. Clara Maass, a civilian nurse, had not been one of the volunteers. She did volunteer for another, later, experiment designed and carried out in Cuba by Juan Guiteras, a Cuban physician, and MAJ William C. Gorgas, MC, USA. The experiment was intended to demonstrate that a mosquito, having bitten a patient with<i>mild</i>yellow fever, transmits a mild form of the disease. The Surgeon General in Washington referred the protocol of this experiment for comment to Walter Reed, long since out of Cuba, and Reed wrote to his friend Gorgas, "I had to advise against further experimentation on human
Electrophysiological Deterioration During Long-Duration Ventricular Fibrillation
Authors: Oscar H. Tovar, Janice L. Jones
Journal: Circulation (2000)

Background —Probability of survival from sudden cardiac arrest caused by ventricular fibrillation (VF) decreases rapidly with fibrillation duration. We hypothesized that cellular ischemia/fibrillation-induced electrophysiological deterioration underlies decreased survival. Methods and Results —We determined fibrillation monophasic action potential (MAP) morphology including action potential frequency content, duration, cycle length, developing diastolic intervals, and amplitude as a function of ischemic fibrillation duration in 10 isolated rabbit hearts. We also correlated ECG frequency (used clinically) and MAP amplitude and frequency. Fibrillation cycle length and diastole duration increased, whereas APD 100 shortened significantly with time ( P &lt;0.001). Between 1 and 3 minutes, diastole appeared primarily as the result of APD 100 shortening, with only small changes in cycle length. Between 2 and 5 minutes, diastole increased primarily as the result of increased cycle length. Diastole developed progressively from 5% of VF cycles at 5 seconds to ≈100% of VF cycles by 120 seconds ( P &lt;0.001). Diastole increased from 1% of cycle length at 5 seconds to 62% at 5 minutes. Its duration increased from 4.7 ms at 5 seconds to 90 ms at 5 minutes ( P &lt;0.001). Both MAP and ECG 1/frequency closely correlated with fibrillation cycle length. Conclusions —These results show a rapid and progressive electrophysiological deterioration during fibrillation, leading to electrical diastole between fibrillation action potentials. This rapid deterioration may explain the decreased probability of successful resuscitation after prolonged fibrillation. Therefore, a greater understanding of cellular deterioration during fibrillation may lead to improved resuscitation methods, including development of specific defibrillator waveforms for out-of-hospital cardiac arrest.
Landmark article Sept. 4, 1920: The nonoperative determination of patency of fallopian tubes by means of intra-uterine inflation with oxygen and the production of an artificial penumoperitoneum. By I.C.Rubin
Authors: I. C. Rubin
Journal: JAMA (1983)

The determination of patency of fallopian tubes has hitherto been possible only by direct inspection and palpation obtained by laparotomy. Physician examination was wholly inadequate because it still left the question of patency a matter of speculation. This is especially true when, as in certain intances, the tubes are sealed tight at their fimbriated end, although no distention of the lumen is present. In other instances it is hard to diagnose occlusion of the tube due to hydrosalpinx when the walls are flaccid. Some tubes are closed by adhesions secondary to a peritonitis that arises outside of the gynecologic domain. No matter how clear the history, the question as to whether such a tube is patent or not is always a matter of doubt. The same holds true in cases in which the tube may be occluded by a tumor. It is often not possible to distinguish whether a mass
AN ARTICLE CONTRIBUTED TO AN ANNIVERSARY VOLUME IN HONOR OF DOCTOR JOSEPH HERSEY PRATT
Authors: FRANK T. FULTON
Journal: Annals of Internal Medicine (1938)

Article1 February 1938AN ARTICLE CONTRIBUTED TO AN ANNIVERSARY VOLUME IN HONOR OF DOCTOR JOSEPH HERSEY PRATTCORONARY ARTERY DISEASE; A HISTORICAL SKETCH*FRANK T. FULTONFRANK T. FULTONSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-11-8-1433 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptInterest in any subject is usually accentuated by some study of its early history, and in connection with some of the now well understood diseases a fascinating story may be written.Medical students of 20 years ago seldom, if ever, heard of the clinical diagnosis of coronary thrombosis. Angina pectoris on the other hand was frequently discussed; that diagnosis, when made, carried with it in the minds of most, the sentence of a short life, terminating in sudden death. Now-a-days coronary thrombosis is up for daily discussion in a routine hospital visit; a fairly good guess can be made as...Bibliography HEBERDEN W: Commentaries on the history and cure of diseases, London, 1802, Chap. 70, p. 363-366. Google Scholar OSLER W: Lumleian Lectures on Angina Pectoris, Lancet, 1910, 839. CrossrefGoogle Scholar GARRISON FH: Introduction to History of Medicine, 1921, p. 370. Google Scholar MAJOR RH: Classic descriptions of disease, 1932, 394. Google Scholar OSLER W: Angina pectoris and allied states, 1901, pp. 2-4 and various other quotations. Google Scholar PARRY CH: Inquiry into the symptoms and causes of the syncope anginosa, commonly called angina pectoris, 1799. (Quotation from Jenner's letter.) Google Scholar BURNS A: Observations on diseases of the coronaries, and on syncope anginosa, 1809. Google Scholar LATHAM PM: Diseases of the heart, Barrington and Haswell, Philadelphia, 1847. Lecture 37; p. 336. Google Scholar STOKES W: Diseases of the heart and aorta, Lindsay and Blakiston, Philadelphia, 1854. CrossrefGoogle Scholar MAJOR RH: Classic description of disease, Charles C. Thomas, 1932, p. 399. Google Scholar DOCK G: Medical and Surgical Reporter, 1896, lxxv, 1. Google Scholar HERRICK JB: Trans. Assoc. Am. Phys., 1912, xxvii. Google Scholar HERRICK JB: Jr. Am. Med. Assoc., Dec. 7, 1912; Same paper as above, entitled, Clinical features of sudden obstruction of coronary arteries, lix, 2015. Google Scholar HERRICK JB: Thrombosis of the coronary arteries, Trans. Assoc. Am. Phys., 1918, xxxiii, 409. Google Scholar D'ARCY POWERS : Chronologia Medica, 1923, Paul B. Hoeber, New York. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Providence, Rhode Island*Received for publication August 14, 1937. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByÜber die Entstehung des Herzinfarkts 1 February 1938Volume 11, Issue 8Page: 1433-1442KeywordsAnginaThrombosis Issue Published: 1 February 1938 PDF DownloadLoading ...
Textbook of Psychiatry for Medical Practice.
Authors: Garfield Tourney
Journal: JAMA (1963)

Dr. Hofling, assisted by five associates, has written a text of psychiatry primarily for the general physician. Composed to overcome the limitations of previous texts with their extensive discussions of gross psychopathology, it aims to present a view of emotional disorders as seen in the office and hospital practice of the generalist. In a number of ways this goal has been achieved, but on the other hand significant deficiencies occur. Instead of presenting clinical syndromes according to the standard nomenclature of the American Psychiatric Association, the authors review psychiatric problems as they are seen in the general practice of medicine. This approach is highlighted in an excellent chapter by Dr. Louis A. Gottschalk, who gives a clear and straightforward presentation with interesting clinical examples on mourning, situational problems, sexual difficulties, traumatic neuroses, headache, backache, obesity, among others. A section on psychiatry and surgery is valuable, but neglects to discuss in
High-definition endoscopy with i-Scan and Lugol’s solution for more precise detection of mucosal breaks in patients with reflux symptoms
Authors: A. Hoffman, N. Basting, M. Goetz, A. Tresch, J. Mudter, S. Biesterfeld, P. Galle, M. Neurath, R. Kiesslich
Journal: Endoscopy (2009)

See also: Commentaire de travail de A. Hoffman et al., pp. 107Endoscopy 2009; 41(02): 250-250DOI: 10.1055/s-0032-1306725
THE ROLE OF PREOPERATIVE NT-PROBNP IN ORTHOPEDIC ELDERLY PATIENTS WITH NORMAL LEFT VENTRICULAR SYSTOLIC FUNCTION
Authors: Jae-Youn Moon, Eun-Jung Ko, Sang-Hoon Kim, Woo-In Yang, Jung-Hoon Sung, In Jai Kim, Sang-Wook Lim, Dong-Hun Cha
Journal: Journal of the American College of Cardiology (2014)
Lung Cancer Staging With Minimally Invasive Endoscopic Techniques
Authors: Domenico Galetta, Maria Serra, Lorenzo Spaggiari
Journal: JAMA (2008)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
A man with deteriorating ability to live independently
Authors: M. J. U. Novak, S. J. Tabrizi
Journal: BMJ (2011)

A 55 year old man was brought to see his general practitioner by his wife. She said that he had been healthy and active when younger, but that his ability to function independently had declined over the previous few years to the point where she was now helping him with all activities of daily living. If she did not help or prompt him, he did not wash or dress himself and would sit on the sofa all day doing nothing. He had no history of physical illness, but he had experienced bouts of depression for many years and had developed obsessive-compulsive behaviours over the past 15 years. These included picking up litter in the street and arranging his belongings in lines. On questioning about illness in the family, he said that he thought his mother had been diagnosed with Alzheimer’s disease in her 40s.

On examination, he had occasional involuntary movements in his arms. Examination of the limbs was otherwise normal. He was fully oriented and scored 26/30 on the mini-mental state examination.

After the patient and his family were counselled at a specialist genetics centre, he underwent genetic testing and the presumptive diagnosis was confirmed.



### 1 What is the most likely diagnosis?

#### Short answer

Huntington’s disease.

#### Long answer

The combination of psychiatric and cognitive symptoms with involuntary movements makes Huntington’s disease the most likely diagnosis. This is supported by the presence of a dementing illness in the patient’s mother, …
Incidence of gastric side effects in controlled trials with unbranded aspirin and with various long-acting aspirin preparations.
Authors: J M Gumpel
Journal: Annals of the Rheumatic Diseases (1978)

Incidence of gastric side effects in controlled trials with unbranded aspirin and with various long-acting aspirin preparations Sir, Huskisson and Scott (1978) record an amazingly high incidence of gastric side-effects with 'aspirin' in osteo- arthrosis, but offer no comment on this nor on the form of aspirin used.Reference 'Aspirin' Named aspirin preparations Gastric side Daily dose Gastric side Daily dose
Development of Bacteriuria in a Hypertensive Population
Authors: ALVIN P. SHAPIRO
Journal: Annals of Internal Medicine (1971)

A prospective study of the development of bacteriuria was undertaken in 800 hypertensive patients, using the catalase test on urine voided at each clinic visit as a screening technique. The prevalence of patients with positive catalase tests rose from 26% to 46% at the end of 7 years, with the prevalence of bacteriuria from subsequent urine cultures in catalase-positive patients similarly rising from approximately 6.5% to 13.2%. These data indicate that bacteriuria appears in a hypertensive population at a rate of approximately 1% yearly and support the concept that pyelonephritis is a predictable complication of hypertension rather than a primary etiologic factor. Whether the vulnerability to infection is greater than in a normotensive patient population was suggested but not clearly established by the data. The data did, however, demonstrate an increased morbidity and mortality from hypertension in hypertensive patients with urinary tract infection. The results also define the role of the catalase test as a procedure for rapid, inexpensive, and repeated screening of a large population for urinary tract infection.
Results of Report Cards for Patients with Congestive Heart Failure Depend on the Method Used To Adjust for Severity
Authors: Roy M. Poses, Donna K. McClish, Wally R. Smith, Elizabeth C. Huber, F. Lynne W. Clemo, Brian P. Schmitt, Donna Alexander, Edward M. Racht, Christopher C. Colenda
Journal: Annals of Internal Medicine (2000)

Background: The validity of outcome report cards may depend on the ways in which they are adjusted for risk. Objectives: To compare the predictive ability of generic and disease-specific survival prediction models appropriate for use in patients with heart failure, to simulate outcome report cards by comparing survival across hospitals and adjusting for severity of illness using these models, and to assess the ways in which the results of these comparisons depend on the adjustment method. Design: Analysis of data from a prospective cohort study. Setting: A university hospital, a Veterans Affairs (VA) medical center, and a community hospital. Patients: Sequential patients presenting in the emergency department with acute congestive heart failure. Measurements: Unadjusted 30-day and 1-year mortality across hospitals and 30-day and 1-year mortality adjusted by using disease-specific survival prediction models (two sickness-at-admission models, the Cleveland Health Quality Choice model, the Congestive Heart Failure Mortality Time-Independent Predictive Instrument) and generic models (Acute Physiology and Chronic Health Evaluation [APACHE] II, APACHE III, the mortality prediction model, and the Charlson comorbidity index). Results: The community hospital's unadjusted 30-day survival rate (85.0%) and the VA medical center's unadjusted 1-year survival rate (60.9%) were significantly lower than corresponding rates at the university hospital (92.7% and 67.5%, respectively). No severity model had excellent ability to discriminate patients by survival rates (all areas under the receiver-operating characteristic curve < 0.73). Whether the VA medical center, the community hospital, both, or neither had worse survival rates on simulated report cards than the university hospital depended on the prediction model used for adjustment. Conclusions: Results of simulated outcome report cards for survival in patients with congestive heart failure depend on the method used to adjust for severity.