tbuckley/cabot-search huggingface dataset:
Permeability-increasing activity in hereditary angioneurotic edema plasma
Authors: Virginia H. Donaldson, Oscar D. Ratnoff, Wilmar Dias Da Silva, Fred S. Rosen
Journal: Journal of Clinical Investigation (1969)

Plasma from persons with hereditary angioneurotic edema readily developed the capacity to increase vascular permeability and to induce the isolated rat uterus to contract. Both activities resided in a small, heat-stable molecule that was apparently a polypeptide. Crude preparations of the polypeptide were inactivated during incubation with trypsin. They also failed to produce pain and erythema, but caused markedly increased vascular permeability in human skin. These characteristics differ from those of bradykinin, from which crude preparations of the polypeptide could also be distinguished by electrophoretic mobility and paper chromatographic behavior. Proof that the polypeptide is truly different from bradykinin must await its further purification. Histamine played no role in the activities observed. Although the enzymes functioning to release the permeability factor and kinin activities in hereditary angioneurotic edema plasma were not clearly defined, one or more plasma enzymes other than C'1 esterase presumably participated either in conjunction with C'1 esterase or in pari passu events to release the polypeptide mediating these activities.
Follow up by telephone
Authors: A J Robinson, C Shergold, E Allason-Jones, P French
Journal: BMJ (1995)

Amoxycillin 34 (29 6) 2274 (86.2) 1190 (83 6) 1084 (89 3) 172 (915) Co-amoxiclav 6 (5 2) 434 (16 5) 232 (16 3) 202 (16 6) 94 (50 0) Co-trimoxazole 79 (68 7) 1329 (50 4) 726 (51 0) 603 (49 7) 71 (37 8) Erythromycin 112 (97 4) 2284 (86-6) 1231 (86 4) 1053 (86 7) 151 (80 3) Tetracycline 34 (29 6) 343 (13-0) 159 (11-2) 184 (15-2) 25 (13-3) Trimethoprim 24 (20 9) 1024 (38 8) 521 (36 6) 503 (41-4) 85 (45 2) Cephalosporins 63 (54 8) Data not aggregated in these surveys 35 (18-6) Metronidazole 18 (15-7) 409 (15-5) 228 (16-0) 181 (14-9) 1 (0 5) Chloramphenicol: Oral 12 (10-4) Topical 3(2 6)
Interim report on the A/H1N1 influenza virus pandemic in Marseille, France, April-November 2009
Authors: A. Nougairede, L. Ninove, C. Zandotti, S.-D. Thiberville, C. Gazin, B. La Scola, R.N. Charrel, X. de Lamballerie
Journal: Clinical Microbiology and Infection (2010)
Abstract P2-01-16: Role of 18 FDG PET/CT in axillary staging in early breast cancer
Authors: Cristina Noblia, Eugenia Azar, Dolores Mansilla, Amilcar Osorio, Eduardo Armanasco, Diana Montoya, Martin Ipiña, Gaston Berman, Eduardo Gonzalez, Christian Gonzalez, Gabriel Bruno, Patricia Parma, Carla Pulero, Ana Alvarez
Journal: Cancer Research (2015)

Abstract OBJETIVE To evaluate the 18F-FDG PET/CT capacity for the detection of axillary metastases and compare results with sentinel lymph node biopsy (SLNB).MATERIAL AND METHODS: 99 female patients with clinical T1T2N0 breast cancer were included. Patients with recent breast or axillary surgery, T3T4 disease, ductal carcinoma in situ, inflammatory carcinoma, uncontrolled diabetes mellitus and pregnant or lactation patients were excluded. Pre-operative FDG PET-CT was performed 15 days before surgery, SLNB took place with the combined method (radioisotopes and patent blue). Pearson and Spearman correlation test were used to evaluate association of main variables with a significance level (p) of 0.05.RESULTS: Breast PET-CT results: 80 positive PET/CT. Negative PET/ CT in 19 patients (4invasive lobular carcinoma, 7 tumors &amp;lt;7mm) Sensitivity 81%, specificity 100%.97 patients were operated (2 were stage IV with no surgery criteria). We found significant correlation of the FDG tumor uptake (SUV) with tumor size (p&amp;lt; 0.0001), histological grade (p&amp;lt; 0.009), nuclear grade (p&amp;lt;0.001), mitotic grade (p&amp;lt; 0.007) and Ki 67 (p&amp;lt; 0.0001).In all cases the correlation was positive.There was no correlation with hormonal receptors rate.Axillary PET CT results: positive PET/CT in 16 patients (16%). Of this 6 SNLB were negative (FPR= 9%). Specificity 91%, PET /CT were negative in 81 patients (84%), 17 had axillary metastases(5 micrometastases, 2 isolated tumor cells and 2 lobular carcinoma).Sensitivity:37%.FNR=63%. Correlation of histopatological axillary metastases was positive with breast tumor SUV (P&amp;lt;0.0002) and tumor size (p&amp;lt;0.01), but was not significant with histological, nuclear and mitotic grade, Ki 67,hormonal receptor rate and molecular subtype CONCLUSION: 1- PET / CT does not provide benefits for axillary staging in initial stages due to its low spatial resolution (6-8 mm) 2 –A negative axillary by PET/CT does not replace the sentinel node technique. 3 – We can suspect the presence of axillary metastases when there is an intense FDG uptake in the breast tumor. Citation Format: Cristina Noblia, Eugenia Azar, Dolores Mansilla, Amilcar Osorio, Eduardo Armanasco, Diana Montoya, Martin Ipiña, Gaston Berman, Eduardo Gonzalez, Christian Gonzalez, Gabriel Bruno, Patricia Parma, Carla Pulero, Ana Alvarez. Role of 18 FDG PET/CT in axillary staging in early breast cancer [abstract]. In: Proceedings of the Thirty-Seventh Annual CTRC-AACR San Antonio Breast Cancer Symposium: 2014 Dec 9-13; San Antonio, TX. Philadelphia (PA): AACR; Cancer Res 2015;75(9 Suppl):Abstract nr P2-01-16.
CATHARSIS IN ACUTE UPPER RESPIRATORY INFECTIONS
Authors: Fred N. Miller
Journal: Annals of Internal Medicine (1935)

Article1 February 1935CATHARSIS IN ACUTE UPPER RESPIRATORY INFECTIONSFRED N. MILLER, M.D.FRED N. MILLER, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-8-8-972 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptSince the various factors involved in the etiology of the common cold and of grippal infections are at best imperfectly understood, it is not surprising that the therapeutic management of acute upper respiratory disorders has not been satisfactorily established. Present treatment is largely a mélange of traditional procedures which are varied from time to time usually only in minor details. The evaluation of any therapeutic procedure or agent in the treatment of these infections is especially difficult for two reasons. In the first place there is a considerable variation in the manifestations of respiratory infections not only from season to... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Eugene, Oregon*Received for publication June 30, 1934.From the Student Health Service, University of Oregon. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byThe Common Cold 1 February 1935Volume 8, Issue 8Page: 972-973KeywordsCommon coldEtiologyMedical servicesUpper respiratory tract infections ePublished: 1 December 2008 Issue Published: 1 February 1935 PDF downloadLoading ...
Old Women at Arles
Authors: M. Therese Southgate
Journal: JAMA (1999)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Abstract P005: Evaluation of the Association between the Free Fatty Acid to serum Albumin Ratio with the Time to Cardiac Repolarization
Authors: Baqiyyah N Conway, Rhobert W Evans, Orchard Trevor
Journal: Circulation (2014)

Background: Elevated free fatty acid (FFA) levels have been shown to increase cardiac repolarization time and are a hypothesized mediator of arrhythmic death. However, as albumin binds and transports FFA, it has been argued that it is the ratio of serum FFA to serum albumin (SA) that is critical. As FFA are chronically elevated in type 1 diabetes and form a major part of the counterregulatory response to hypoglycemia, we investigated the association of the FFA-to-SA ratio with the corrected Q-T (Q-Tc) interval in 87 men and 96 women with type 1 diabetes from the Pittsburgh Epidemiology of Diabetes Complications Study. We also investigated whether this relationship varied by cardiac autonomic neuropathy (CAN: R-R interval&lt;1.1) status. Methods: FFAs were measured using a colorimetric method in participants with a mean age and diabetes duration of 44 and 33 years, respectively. The corrected Q-T interval was calculated using Hogdes formula and the FFA-SA ratio determined as FFA (mmol/L) ÷ SA (mg/dL). Because of the sexual dimorphism in FFA metabolism and the Q-T interval, analyses were also conducted sex-specifically. Results: Mean (std) FFA levels were 0.95 (o.48) mmol/l and did not vary by sex (men vs women: 0.93 (0.46) vs 0.96 (0.49) mmol/L, p=0.76). The FFA-SA ratio demonstrated a modest association with Q-Tc interval in men (r=0.23, p=0.03), but no association in women (r=-0.07, p=0.48). Overall, in multivariable analyses controlling for sex, visceral adipose tissue, blood glucose levels and albumin excretion rate, FFA-SA, and CAN, a significant interaction was observed between the FFA-SA ratio and CAN in the association of the Q-Tc interval (p=0.03). FFA remained significantly associated with the Q-Tc interval in those without CAN (p&lt;0.05), but not in those with CAN (p=0.30). Sex-specific analyses revealed that although no significant FFA-SA ratio and CAN interaction was observed in men (p=0.42), a relationship between the FFA-SA ratio and Q-Tc interval existed in men free of CAN (p=0.04). No association was observed in women with or without CAN. Conculsion: We conclude that a higher FFA-SA ratio is associated with an increased time to cardiac repolarization in those without CAN, particularly in men, helping to explain why the "dead in bed" syndrome is predominantly seen in men.
Abstract 11251: Long Term Benefits of Human Embryonic Stem Cell-Derived Cardiac Progenitors Embedded Into a Fibrin Scaffold
Authors: Philippe Menasché, Alain Bel, Hany Nemetalla, Valérie Vanneaux, Valérie Bellamy, Estelle Robidel, Pierre Joanne, Solène Boitard, Marie-Cécile Périer, Albert A Hagège, Patrick Bruneval, Jérôme Larghero, Onnik Agbulut
Journal: Circulation (2014)

Introduction: Cardiac commitment of cells and biomimetic scaffolds have been shown to independently improve the therapeutic efficacy of stem cells. Hypothesis: We tested the combination of these two approaches in a rat model of myocardial infarction subjected to a prolonged follow-up. Methods: Eighty rats underwent permanent coronary artery ligation. Five to 7 weeks after myocardial infarction, those with an echocardiographically-measured ejection fraction (EF) ≤ 55% were reoperated on and randomly allocated to receive an epicardial cell-free fibrin patch (n=25), a fibrin patch loaded with 700,000 human embryonic stem cell (ESC)-derived SSEA1+ cardiac progenitor cells (n=30) or to serve as sham-operated controls (n=25). LV function was assessed monthly until 4 months. Hearts were then processed for the assessment of fibrosis, angiogenesis and cell proliferation and the tissue content of multiple cytokines and growth factors (by qPCR). A heart failure score was then built by integrating the absolute change...
Abstract S5-01: The Connecticut experiment: 4 years of screening women with dense breasts with bilateral ultrasound
Authors: Jean M Weigert
Journal: Cancer Research (2015)

Abstract OBJECTIVE: To determine if the addition of screening breast ultrasound in women with mammographically normal but dense breasts has increased breast cancer detection over the 4 years since the legislation was first enacted in 2009. METHODS: The study utilized a retrospective chart review. Data collected included: (1) total number of screening mammograms; (2) total number of dense breast screening ultrasounds; (3) screening ultrasound Breast Imaging Reporting Data System (BI-RADS) code results; (4) biopsy results; and (5) demographic data on women with malignant biopsies. Data was obtained from included sites from October 2009 through December 2013. FINDINGS: Data was collected from 2 Radiology practices with a total of 5 sites. In year 1, 30670 mammograms and 2706 screening ultrasounds were performed. In year 2, 32050 mammograms and 3351 ultrasounds; in year 3, 32230 mammograms and 4128 ultrasounds and in year 4, 27937 mammograms and 3331 ultrasounds were performed. In year 1, 151 ultrasounds were BIRADS 4 or 5 with 11 cancers detected. The PPV was 7.1%; the detection rate was 4/1000 and 22% of eligible women had the study (assuming 40% of women have dense breasts). In year 2, 180 ultrasounds were BIRADs 4 and 5 with 11 cancers detected. The PPV was 6.1% and the cancer detection rate was 3.2/1000 with 26% of eligible women having the study. In year 3 148 ultrasounds were BIRAD 4 and 5 with 13 cancers detected. The PPV was 8.1% and the cancer detection rate was 3.2/1000 with 32% of eligible women having the study. In year 4, 53 ultrasounds were BIRAD 4 and 5 with 11 cancers. The PPV was 17.2% with the cancer detection rate of 3.3/1000 and 28% of eligible women having the study. Four Years of Screening Breast Ultrasound Data Year 1Year 2Year 3Year 4Screening Mammograms30670320503223027937Breast Ultrasounds for Dense Breasts2706335141283331BIRAD 4 and 5 Ultrasounds15118017853Cancers11111311PPV7.16.18.117.2Number Cancers per 1000 Screened4.03.23.23.3% Eligible Screened22.126.132.028.3 CONCLUSIONS: Based on the data collected from these sites, screening breast ultrasound in women with dense breast parenchyma detects mammographically occult malignancy. Over the 4 years studied, the PPV improved from 7% to 17.2% indicating that the selection of lesions biopsied was more accurate with fewer false positives. The rate of detection in the first year was 4.0/1000 and then remained stable at 3.2/1000 in the three subsequent years. Of concern, the number of eligible women who elect to have the additional test remains low at about 30% which is due to several factors including education and cost. Citation Format: Jean M Weigert. The Connecticut experiment: 4 years of screening women with dense breasts with bilateral ultrasound [abstract]. In: Proceedings of the Thirty-Seventh Annual CTRC-AACR San Antonio Breast Cancer Symposium: 2014 Dec 9-13; San Antonio, TX. Philadelphia (PA): AACR; Cancer Res 2015;75(9 Suppl):Abstract nr S5-01.
Abstract 3651: Natural killer cells eradicate galectin-1 deficient glioma in the absence of adaptive immunity
Authors: Gregory J. Baker, Viveka Nand Yadav, Peter Chockley, Robert Doherty, Michael Ritt, Sivaraj Sivaramakrishnan, Maria G. Castro, Pedro R. Lowenstein
Journal: Cancer Research (2014)

Abstract Natural killer (NK) cells safeguard against early tumor formation by seeking out and destroying transformed target cells in a process referred to as NK immunosurveillance. While it is clear that malignant brain tumors such as glioblastoma (GBM) evade NK-mediated tumor suppression, the precise mechanisms by which this occurs remain unknown. We now show that shRNA-mediated knockdown of the β-galactoside-binding lectin, galectin-1 (gal-1), in malignant glioma cells leads to the failure to form lethal intracranial tumors in RAG1-/- mice, a mouse strain devoid of adaptive immunity. However, gal-1 deficient glioma growth is fully restored on implantation into the brain of severely immunocompromised NOD-scid IL2Rg null mice, which lack both adaptive and innate immune function, thus implicating the innate immune response in the early rejection of gal-1 deficient glioma. Immunodepletion of NK cells in RAG1-/- or C57BL/6J mice using anti-asialo GM1 or anti-NK1.1 antibodies permit the growth of large gal-1 deficient gliomas, while macrophage depletion with clodronate liposomes only permits limited tumor growth. This combined result suggests that NK cells and macrophages may work together to achieve gal-1 deficient glioma rejection. Antigen-specific IFN-γ ELISpot assays using splenocytes from immunocompetent C57BL/6J mice indicate that gal-1 deficient glioma is cleared prior to the onset of an adaptive anti-tumor immune response. Flow cytometric analysis of brain tumor-infiltrating immune cells reveal that gal-1 deficient gliomas contain significantly more macrophages and granzyme B+ NK cells compared to gal-1 expressing gliomas. In-vitro experiments further show that gal-1 deficient glioma cells are inherently over 3-times more sensitive to NK-mediated tumor lysis, fail to suppress pro-inflammatory (M1) microglial activation, and secrete pro-inflammatory cytokines IL-1β, IL-12p70, and CXCL2. We conclude that glioma-derived gal-1 is a powerful inhibitor of NK-mediated cytotoxicity in-vivo, and predict that its suppression will be of therapeutic value in the treatment of human malignant brain tumors by dramatically heightening anti-tumor NK immunosurveillance. Citation Format: Gregory J. Baker, Viveka Nand Yadav, Peter Chockley, Robert Doherty, Michael Ritt, Sivaraj Sivaramakrishnan, Maria G. Castro, Pedro R. Lowenstein. Natural killer cells eradicate galectin-1 deficient glioma in the absence of adaptive immunity. [abstract]. In: Proceedings of the 105th Annual Meeting of the American Association for Cancer Research; 2014 Apr 5-9; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2014;74(19 Suppl):Abstract nr 3651. doi:10.1158/1538-7445.AM2014-3651
Abstract 1695: CKD-581, a novel histone deacetylase inhibitor, synergistically enhances Bortezomib cytotoxicity in multiple myeloma cells
Authors: Chansu Lee, Kwang-Sung Ahn, Woo June Jung, Youngil Koh, Hyo Jung Kim, Hyun Jung Lee, Hwi-Joong Yoon, Sung-Soo Yoon
Journal: Cancer Research (2014)

Abstract For Multiple Myeloma (MM), better anti-MM therapies need to be developed in order to treat refractory, relapsed, and newly diagnosed MM. Recently, Histone deacetylase inhibitors (HDACIs) as a combined drug with bortezomib have been evaluated for the treatment of MM. In this study, we examined to determine the anti-MM effects of a novel HDACI, CKD-581, in MM cells. We treated MM cells with CKD-581 either alone or in combination with Bortezomib. Treatments of 9 different MM cell lines with CKD-581 resulted in dose-and time-dependent growth arrest accompanied by the induction of p21 expression and the reduction of cMYC. CKD-581 enhanced Bortezomib-induced cell growth arrest and apoptosis by further reduction of NF-kB mediated cell signaling pathway, which resulted in functional blockage of ubiquitination-related genes. CKD-581, alone or combined with bortezomib, also abrogated the G2/M cell cycle checkpoint, potentially through the suppression of CHK1 expression as well as synergic growth arrest via induction/reduction of CHKs and cMYC, as revealed in combined treatment of CDK-581 and bortezomib. CKD-581-induced sensitization of Bortezomib resistant MM cells to cytotoxic treatment resulted in an increased number of apoptotic cells as judged by annexin V-positivity and the presence of cleaved caspase-3. In addition, CKD-581 effectively induced the apoptosis of MM cells, which were co-cultured with BMSCs obtained from MM patients' BM. CKD-581 effectively inhibited the secretion of IL-6/sIL-6 and HGF, involved in bone lesion, from MM patients' BMSCs. In animal model, CKD-581 was well tolerated, and resulted in tumor growth inhibition and prolonged survival. In summary, the HDAC inhibitor, CKD-581, is a promising therapeutic agent for MM patients, especially when used in combination with Bortezomib. Citation Format: Chansu Lee, Kwang-Sung Ahn, Woo June Jung, Youngil Koh, Hyo Jung Kim, Hyun Jung Lee, Hwi-Joong Yoon, Sung-Soo Yoon. CKD-581, a novel histone deacetylase inhibitor, synergistically enhances Bortezomib cytotoxicity in multiple myeloma cells. [abstract]. In: Proceedings of the 105th Annual Meeting of the American Association for Cancer Research; 2014 Apr 5-9; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2014;74(19 Suppl):Abstract nr 1695. doi:10.1158/1538-7445.AM2014-1695
Arabian Medicine and Its Influence on the Middle Ages.
Authors: Donald Campbell
Journal: JAMA (1926)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
135. A New Ligand-Pseudoreceptor System for the Generation of Adenoviral Vectors with Altered Tropism
Authors: Yue Zeng, Jairo Jaime, Lucie Bourget, Dreg D. Crescenzo, Maureen O'Connor, Bernard Massie
Journal: Molecular Therapy (2004)

Top of pageAbstract
One strategy for the development of Ad vectors (AdV) for the delivery of transgenes in specific tissues relies both on the ablation of native tropism and the introduction of new tropism for target cells. Ablation of AdVs intereaction with their natural receptors renders them unable to grow in current cell lines. Consequently such ablated AdVs require new packaging cells for their generation. Here we describe the use of a couple of high affinity complementary peptides E-coil and K-coil, to create a new cell entry pathway for the native tropism-ablated AdV. E-coil and K-coil are artificial peptides containing from 3 to 5 repeats of 7 amino acids. The strength of interaction between the artificial coil peptides increases with the number of repeats. An E-coil (5 repeats)-containing pseudo-receptor was first expressed into 293 cells (293E). Then, we have cloned in the fiber knob 3, 4 and 5 repeats of K-coil. Insertion of K-coil with 3 or 4 repeats had no deleterious effect on fiber trimerization whereas insertion of 5 repeats dramatically reduces it. Therefore K-coil of 4 repeats (K4) was inserted into the fiber of a CAR-ablated virus (AdFK4m/GFP), since K4 can keep high affinity to 5 repeats of E-coil, without disturbing fiber trimerization. The transduction level of the tropism modified-virus AdFK4m/GFP was 20 times higher in 293E stable cell line then in 293 cells without the pseudo-receptor. Moreover, the soluble peptide K-coil inhibited the transduction of AdF4Km/GFP into 293E cells, whereas soluble fiber had no effect. This indicates that the transduction of the 293E packaging cell line by K-coil-incorporated AdV was taken place via E-coil and K-coil interaction. Such a system is therefore suitable for the production of re-targeted AdV.