tbuckley/cabot-search huggingface dataset:
Abstract 1675: Variations in the composition of inflammatory infiltrates are associated with persistence or regression of bronchial dysplasia
Authors: Mary C. O'Keefe, Lori Dwyer-Nield, Michael Edwards, Robert L. Keith, Wilbur A. Franklin, Michio Sugita, York E. Miller, Micah Friedman, Meredith Tennis, Kevin S. Choo, Gregory Hickey, Jeannine Porter, Storey Wilson, Andrea Osypuk, Mary Weiser, Adrie van Bokhoven, Mark Geraci, Raphael Nemenoff, Daniel T. Merrick
Journal: Cancer Research (2014)

Abstract INTRODUCTION: The clinical course of dysplastic bronchial lesions is variable. While some regress, others progress to invasive carcinoma. We sought to identify how variations in inflammatory infiltrates might influence the clinical outcome of dysplastic bronchial lesions. METHODS AND RESULTS: Gene expression microarray analyses identified 318 genes that distinguish persistent from regressive bronchial dysplastic lesions. Pathway analysis utilizing this genelist was performed using Ingenuity© software. Gene expression data showed several inflammation related pathways with statistically different levels of activity in persistent versus regressive lesions. Expression of genes associated with CD4 positive T-cells and HLA-DRA positive macrophages were both increased in regressive lesions. To further investigate these findings, a similar set of progressive and regressive lesions were selected for immunohistochemical (IHC) analysis. For each biopsy, IHC for T-cell markers CD3, CD4 and CD8 and macrophage marker CD68 was performed. Immunohistochemically positive inflammatory cell subsets were counted in a single high power field corresponding to the focus of maximum inflammation. For each marker, separate counts for epithelium and stroma-associated inflammation were performed. Preliminary IHC data (n=6) shows a strong trend towards increased numbers of macrophages in the dysplastic epithelium of regressive lesions (4.6 fold increase, p=0.082). CONCLUSION: Our findings suggest that differences in inflammatory cell subsets may distinguish persistent and regressive bronchial dysplasia. Preliminary data points to CD4 positive T-cells and intraepithelial macrophages as differentiating factors that correlate with regression. Citation Format: Mary C. O'Keefe, Lori Dwyer-Nield, Michael Edwards, Robert L. Keith, Wilbur A. Franklin, Michio Sugita, York E. Miller, Micah Friedman, Meredith Tennis, Kevin S. Choo, Gregory Hickey, Jeannine Porter, Storey Wilson, Andrea Osypuk, Mary Weiser, Adrie van Bokhoven, Mark Geraci, Raphael Nemenoff, Daniel T. Merrick. Variations in the composition of inflammatory infiltrates are associated with persistence or regression of bronchial dysplasia. [abstract]. In: Proceedings of the 105th Annual Meeting of the American Association for Cancer Research; 2014 Apr 5-9; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2014;74(19 Suppl):Abstract nr 1675. doi:10.1158/1538-7445.AM2014-1675
Abstract 13002: Characteristics and Long-Term Outcomes of Patients With Bicuspid Aortic Valve: Impact of Cardiovascular Surgery
Authors: Ahmad Masri, Vidyasagar Kalahasti, Saqer Alkharabsheh, Joseph F Sabik, Patrick Collier, Lars G Svensson, Leonardo Rodriguez, Bruce W Lytle, Brian P Griffin, Milind Y Desai
Journal: Circulation (2014)

Background: We sought to a) understand characteristics & long-term outcomes of a contemporary group of patients with bicuspid aortic valve (BAV) +/- aortopathy & b) determine if surgery for BAV improves hard outcomes. Methods: We studied 1896 consecutive patients with BAV (age 50±14 years, 75% men) that underwent initial evaluation between 2003-2007, at a tertiary-care center. Baseline clinical, echocardiographic, chest tomography, surgical & outcomes data was recorded. Euroscore was calculated. Endpoint was a composite of death or aortic dissection. Results: Mean left ventricular ejection fraction (LVEF), aortic root size & Euroscore were 55±8 %, 3.6±0.8 cm and 4±2. 671 (35%) patients had aortic root ≥4 cm, 30% had ≥III+ aortic regurgitation (AR) & 10% had mean AV gradient ≥40 mm Hg. At 8±2 years of follow-up, 924 (49%) patients underwent surgery related to BAV [884 AV replacement (+/- combination procedures) and 470 (25%) with ascending aortic grafting] & there were 177 (9%) events (8 dissections). Medi...
Cholesterol guidelines will triple numbers taking drugs
Authors: Deborah Josefson
Journal: BMJ (2001)

The US National Institutes of Health, through its national cholesterol education programme, has issued sweeping new clinical practice and management guidelines designed to lower cholesterol levels.

The guidelines call for more aggressive diagnosis and treatment of hypercholesterolaemia and for a change from the acceptable, healthy level of high density lipoprotein (HDL) from a minimum of 35 mg/dl (0.91 mmol/l) to 40 mg/dl (1.03 mmol/l). They also endorse the wider use of lipid lowering drugs and lifestyle changes.

The new guidelines will substantially increase the number of Americans considered to be at risk of heart disease and expand the number who will receive dietary and drug treatment. The number of Americans who …
Agonists of proteinase-activated receptor 2 induce inflammation by a neurogenic mechanism
Authors: M. Steinhoff, N. Vergnolle, S.H. Young, M. Tognetto, S. Amadesi, H.S. Ennes, M. Trevisani, M.D. Hollenberg, J.L. Wallace, G.H. Caughey, S.E. Mitchell, L.M. Williams, P. Geppetti, E.A. Mayer, N.W. Bunnett
Journal: Nature Medicine (2000)
Abstract 2673: A novel ligand-independent peptide inhibitor of TREM-1 attenuates inflammation and suppresses tumor growth in mice
Authors: Alexander B. Sigalov
Journal: Cancer Research (2014)

Abstract Non-small cell lung cancer (NSCLC) comprises about 85% of all lung cancers, accounting for over 1.5 million new cases annually. Despite advances in therapy, the 5-year survival rate is as low as 15%. The limitations in efficacy and safety associated with available treatments for NSCLC highlight the need for new treatments. As found recently, triggering receptor expressed on myeloid cells (TREM-1) plays a role in NSCLC progression. Inhibition of TREM-1 by short hairpin RNA (shRNA) in macrophages suppresses cancer cell invasion in vitro. In clinical setting, high level of TREM-1 expression in tumor-associated macrophages is associated with cancer recurrence and poor survival of patients with NSCLC. However, the precise function of TREM-1 and the nature of its ligand are not yet known. Here we show that TREM-1 can be specifically silenced in vitro and in vivo using a novel ligand-independent peptide inhibitor, which was designed using a new model of immune signaling, the signaling chain homooligomerization (SCHOOL) model. Blockade of TREM-1 function using non-toxic and non-immunogenic SCHOOL peptide inhibitors: 1) delays tumor growth in xenograft models of human NSCLC and 2) substantially decreases cytokine production in vitro and in vivo. In addition, macrophage-targeted delivery of SCHOOL peptides utilizing lipoprotein-mimicking nanoparticles significantly increased peptide half-life and dosage efficacy. Together, the results suggest that ligand-independent modulation of TREM-1 function using small synthetic peptides might be a suitable treatment for NSCLC and possibly other types of inflammation-associated cancers. Citation Format: Alexander B. Sigalov. A novel ligand-independent peptide inhibitor of TREM-1 attenuates inflammation and suppresses tumor growth in mice. [abstract]. In: Proceedings of the 105th Annual Meeting of the American Association for Cancer Research; 2014 Apr 5-9; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2014;74(19 Suppl):Abstract nr 2673. doi:10.1158/1538-7445.AM2014-2673
Vitrectomy for Complications of Proliferative Diabetic Retinopathy
Authors: William E. Smiddy, William Feuer, W. David Irvine, Harry W. Flynn, George W. Blankenship
Journal: Ophthalmology (1995)

Purpose: To quantitate the effect of diabetic vitrectomy on each patient's visual system and function. Methods: The anatomic and visual acuity outcomes of diabetic vitrectomy among three surgeons at one institution over a 4-year time interval were studied. Outcome parameters describing the visual system function were defined and applied to quantitate the effect on visual system disability. Results: The anatomic and visual success rates and prognostic factors in the cohort of 213 patients by standard statistical analysis were similar to previous studies. The study eye was the eye with better vision in 68 (32%) patients at the conclusion of the study, and vision was equal to the fellow eye in 35 (16%) patients. The mean impairment of the visual system by the American Medical Association Guidelines for Disability was reduced from 61 % preoperatively to 50% postoperatively. The factor associated with greatest degree of reduction of impairment of the visual system was a previtrectomy diagnosis of vitreous hemorrhage. There was at least a one-step improvement of visual system function in 65 (31%) patients. Conclusions: Vitrectomy for complications of severe proliferative diabetic retinopathy is especially valuable in improving the patient's overall visual function. Purpose: To quantitate the effect of diabetic vitrectomy on each patient's visual system and function. Methods: The anatomic and visual acuity outcomes of diabetic vitrectomy among three surgeons at one institution over a 4-year time interval were studied. Outcome parameters describing the visual system function were defined and applied to quantitate the effect on visual system disability. Results: The anatomic and visual success rates and prognostic factors in the cohort of 213 patients by standard statistical analysis were similar to previous studies. The study eye was the eye with better vision in 68 (32%) patients at the conclusion of the study, and vision was equal to the fellow eye in 35 (16%) patients. The mean impairment of the visual system by the American Medical Association Guidelines for Disability was reduced from 61 % preoperatively to 50% postoperatively. The factor associated with greatest degree of reduction of impairment of the visual system was a previtrectomy diagnosis of vitreous hemorrhage. There was at least a one-step improvement of visual system function in 65 (31%) patients. Conclusions: Vitrectomy for complications of severe proliferative diabetic retinopathy is especially valuable in improving the patient's overall visual function.
Abstract 710: The efficacy of tumor-targeting Salmonella typhimurium A1-R on bone metastasis
Authors: Shinji Miwa, Ming Zhao, Shuya Yano, Yong Zhang, Fuminari Uehara, Yasunori Matsumoto, Yukihiko Hiroshima, Mako Yamamoto, Hiroaki Kimura, Katsuhiro Hayashi, Hiroyuki Tsuchiya, Robert M. Hoffman
Journal: Cancer Research (2014)

Abstract We have previously developed a genetically-modified bacterial strain of Salmonella typhimurium (A1-R), which expresses GFP. In this study, we measured the efficacy of A1-R on breast cancer bone metastasis. We established an early-stage bone-metastasis model in nude mice by cardiac injection and a late-stage model by injection into the intramedullary cavity of the tibia using MDA-MB-435 human breast cancer cells (Human breast cancer cell lines co-express neuronal, epithelial, and melanocytic differentiation markers in vitro and in vivo. PLoS One 5, e9712, 2010). Both mouse models of bone metastasis were treated with A1-R. Fluorescence imaging of the mice was performed to visualize the metastatic bone lesions. In a first set of experiments, we showed that A1-R invaded and replicated intracellularly in MDA-MB-435-GFP cells in vitro. A1-R dose-dependently inhibited proliferation of MDA-MB-435-GFP cells. In the early-stage bone-metastasis model, A1-R significantly improved metastasis-free survival. In the advanced-stage bone-metastasis model, A1-R significantly inhibited the growth of the metastatic lesions. These data indicated that A1-R is useful to prevent and inhibit the growth of metastatic breast cancer bone tumors. Citation Format: Shinji Miwa, Ming Zhao, Shuya Yano, Yong Zhang, Fuminari Uehara, Yasunori Matsumoto, Yukihiko Hiroshima, Mako Yamamoto, Hiroaki Kimura, Katsuhiro Hayashi, Hiroyuki Tsuchiya, Robert M. Hoffman. The efficacy of tumor-targeting Salmonella typhimurium A1-R on bone metastasis. [abstract]. In: Proceedings of the 105th Annual Meeting of the American Association for Cancer Research; 2014 Apr 5-9; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2014;74(19 Suppl):Abstract nr 710. doi:10.1158/1538-7445.AM2014-710
Abstract P2-12-09: Psycho-oncological intervention in breast cancer patients - A quantitative analysis of tumor associated fatigue treatment
Authors: Christian Eichler, Pia Multhaupt, Sibylle Multhaupt, Friedrich Wolff, Mathias Warm
Journal: Cancer Research (2015)

Abstract Abstract Background: Although tumor associated fatigue (TAF) or cancer related fatigue (CRF) is not a new concept, no real headway has been made in the quantitative analysis of its successful treatment. Since 20 to 30% of all breast cancer patients suffer from anxiety and/or depression within the first year of their diagnosis, this issue needs to be addressed and a standard treatment protocol has to be developed. Multimodal approaches are currently being used including increased physical activity, pharmaceutical therapy, and psycho-oncological intervention. This study focused on developing a simple, reproducible protocol for the psycho-oncological support of tumor associated fatigue patients. Methods: Between the year 2011 and 2012, 23 breast cancer patients fulfilled the diagnosis TAF requirements and were introduced into this study. All patients had received surgery and were currently being monitored in an adjuvant setting. Our method focused on a psycho-oncological support group using a predetermined, highly structured and reproducible treatment manual. Eight weekly, 90 minute sessions were conducted and patients were evaluated before and after this eight session block. Tumor fatigue specific questionnaires such as the multidimensional fatigue inventory (MFI) as well as the hospital anxiety and depression scale (HADS) were used in order to quantitatively evaluate patient TAF. Results: Of the 23 patients enrolled in the study, only 7 patients fulfilled the TAF diagnostic criteria after the psycho-oncological group treatment. This represents a 70% reduction in diagnosable tumor associated fatigue. The HADS analysis showed a 33% reduction in patient anxiety as well as a 57% reduction in patient depression levels. The MFI scores showed a significant reduction in 4 of the 5 evaluate categories. With the exception of the "mental fatigue" MFI category all results were statistically significant. Conclusion: This study showed that a highly structured, psycho-oncological group intervention will produce significant improvements in breast cancer patient tumor associated fatigue levels after only 8 sessions. This type of group therapy should be recommended as a standard of care for all TAF breast cancer patients. Citation Format: Christian Eichler, Pia Multhaupt, Sibylle Multhaupt, Friedrich Wolff, Mathias Warm. Psycho-oncological intervention in breast cancer patients - A quantitative analysis of tumor associated fatigue treatment [abstract]. In: Proceedings of the Thirty-Seventh Annual CTRC-AACR San Antonio Breast Cancer Symposium: 2014 Dec 9-13; San Antonio, TX. Philadelphia (PA): AACR; Cancer Res 2015;75(9 Suppl):Abstract nr P2-12-09.
First Morning Back
Authors: Larry A Green
Journal: JAMA (2002)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Antioxidants and Risk of Alzheimer DiseaseAntioxidants and Risk of Alzheimer Disease
Authors: Arthur E Varner
Journal: JAMA (2002)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2022 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
434. Recombinant Adeno-Associated Virus 2 -Mediated Anti-Angiogenic Gene Therapy in a Mouse Model of Intraperitoneal Ovarian Cancer
Authors: Tatyana Isayeva, Changchun Ren, Selvarangan Ponnazhagan
Journal: Molecular Therapy (2004)

Tumor anti-angiogenic therapy using gene transfer vectors widens the promise of adjuvant cancer therapy by its ability to produce therapeutic molecules at high concentration within the localized target cells for a sustained period of time with a single administration. Recombinant adeno-associated virus vectors (rAAV) are promising for gene therapy applications due to their long-term transgene expression and wide spectrum of target cells. Our recent studies demonstrated that intramuscular administration of rAAV encoding secretable forms of angiostatin and/or endostatin provided significant growth inhibition of subcutaneously implanted human ovarian cancer cell line, SKOV3.ip1. In the present studies, we sought to evaluate the potential of rAAV encoding angiostatin and endostatin in inhibiting intraperitoneal (i.p.) ovarian cancer growth and dissemination. An i.p. model of ovarian cancer in female athymic mice was established with injection of SKOV3ip1 xenografts. Mice were injected intramuscularly with 1.2 × 1011 v.p./mouse, rAAV encoding endostatin and angiostatin. Control mice either did not receive any vector or were injected with equivalent dose of rAAV-GFP. Three weeks after virus administration, 106 SKOV3ip1 cells were intraperitoneally injected.
Temple Theodore "Tim" Stamm Chalmers Davidson Trevor Davies John Wanless Dickson Richard Leigh Joyce McQuillin B K Naik Shirley Storrier (nee Clarke) Cecil Henry Wilkinson Jonathan Alun Williams
Authors: C. Harris, E. Jellinek, B. Gutteridge, A. Dickson, J. Leigh, D. Madeley, S. Savla, R. Smart, D. Morgan, A. Walmsley
Journal: BMJ (2001)
Abstract 2021: A novel model to study the stroma-induced drug resistance in glioblastoma cells
Authors: Ning Yang, Huaiyang Zhu, Tao Yan, Xiao Liang, Lina Wik Leiss, Per Øyvind Enger, Xingang Li, Jian Wang
Journal: Cancer Research (2014)

Abstract Glioblastomas (GBMs) are lethal cancers with a limited response to chemotherapies. In order to study whether stromal cells convey drug resistance to glioma cells, we have established a 3 D glioma cell-specific bioluminescence assay which mimics the growth of glioma in vivo and allows for direct measurements of tumor cell viability. With lentiviral transfection experiments we have provided a panel of human glioma cell lines stably expressing the luciferase reporter gene. Luciferase expression was proportional to the number of glioma cells, but not influenced by the presence of stromal cells. This way, Luciferase signal detection could be used to monitor glioma cell viability following treatment. Glioma cells alone or cultured with stromal cells can form 3 D spheroids, then treated with Temozolomide and Doxorubicin. Through comparative analysis, stromal cells influenced the sensitivity of different chemotherapy drugs in several glioma cell lines. Experiment also proved bioluminescence assay was more sensitive than MTS assay in co-culture system. This glioma cell-specific bioluminescence platform possibly provided a tool to screen stroma-induced changes in anti-tumor drug activity. Using the platform, we will be able to screen FDA-approved drugs on different glioma cell lines and biopsies, which will potentially guide the selection of tumor associated stromal specific targets for therapeutic validation. Citation Format: Ning Yang, Huaiyang Zhu, Tao Yan, Xiao Liang, Lina Wik Leiss, Per Øyvind Enger, Xingang Li, Jian Wang. A novel model to study the stroma-induced drug resistance in glioblastoma cells. [abstract]. In: Proceedings of the 105th Annual Meeting of the American Association for Cancer Research; 2014 Apr 5-9; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2014;74(19 Suppl):Abstract nr 2021. doi:10.1158/1538-7445.AM2014-2021
Incidence of cutaneous malignant melanoma in Denmark, 1978-2007
Authors: N.B. Fuglede, U.Ø. Brinck-Claussen, I. Deltour, E.H. Boesen, S.O. Dalton, C. Johansen
Journal: British Journal of Dermatology (2011)

Incidence rates of cutaneous malignant melanoma (CMM) have been increasing markedly worldwide. The ongoing debate about possible overdiagnosis remains unresolved.To determine the population-based incidence of CMM in Denmark between 1978 and 2007 and to analyse sex-, site- and extent of disease-specific changes in incidence rates of CMM over time.We used the virtually complete nationwide Danish Cancer Register in this population-based study, which contains data on 25,851 cases reported in Denmark between 1978 and 2007. We calculated age-standardized (world standard population) incidence rates per 100,000 person-years and age-specific rates.The age-standardized incidence rates increased from 6·5 to 14·4 among men and from 8·6 to 18·9 among women. During the last 5 years of the study period, a sudden marked increase was seen in women of all ages and in men aged 65 years or older. The most marked site-specific change was in the incidence of melanoma on the trunk in both men and women. An increase in the rates of disease with regional spread was seen during the last 10 years of observation.The incidence rate of CMM more than doubled in Denmark between 1978 and 2007. The increases in both site-specific incidence rates and CMM with regional spread suggest an association with risk behaviour, such as intermittent sun exposure, although possible overdiagnosis must be taken into account in evaluating the implications of the increase.