tbuckley/cabot-search huggingface dataset:
Prevalence and Implementation of IAQ Programs in U.S. Schools
Authors: Dena Moglia, Alisa Smith, David L. MacIntosh, Jennifer L. Somers
Journal: Environmental Health Perspectives (2005)

In this study, we determined the extent to which U.S. schools are implementing indoor air quality (IAQ) programs. We administered a questionnaire on IAQ programs and practices to a representative sample of schools. Participants were asked to provide information on the use, administration, implementation, challenges, and benefits of the IAQ program in their school. We developed an IAQ Practice Index to determine the level of activity directed toward IAQ in schools. The index was computed based on responses to specific survey questions and was normalized to a range of 0 to 100. Each question was weighted qualitatively according to its contribution to strong IAQ management practices. Forty-two percent of schools in the United States have an IAQ management program, and there has been sustained growth from 1998 through 2002 in the number of schools that have such programs. Nearly half of those schools use the U.S. Environmental Protection Agency's IAQ Tools for Schools program. The IAQ Practice Index scores varied widely for schools with an IAQ management program, suggesting that having a program is not equivalent to implementing effective IAQ policies and procedures. Respondents indicated that their IAQ programs led to improved workplace satisfaction, fewer asthma attacks, fewer visits to the school nurse, and lower absenteeism. When actively supported by the school administration, an IAQ program appears to be a valuable factor in improving the learning environment for U.S. schoolchildren.
PTEN mutations as a cause of constitutive insulin sensitivity and obesity in human beings
Authors: Aparna Pal, Thomas M Barber, Martijn Van de Bunt, Simon A Rudge, Qifeng Zhang, Katherine L Lachlan, Nicola S Cooper, Helen Linden, Jonathan C Levy, Michael JO Wakelam, Lisa Walker, Fredrik Karpe, Anna L Gloyn
Journal: The Lancet (2013)
Severe refractory chronic actinic dermatitis successfully treated with tacrolimus ointment
Authors: R. Abe, T. Shimizu, A. Tsuji, T. Matsumura, H. Shimizu
Journal: British Journal of Dermatology (2002)

Journal Article Severe refractory chronic actinic dermatitis successfully treated with tacrolimus ointment Get access R. Abe, R. Abe Department of Dermatology, Hokkaido University Graduate School of Medicine, N 15 W 7, Kitaku, Sapporo 060‐8638, Japan E‐mail: aberi@med.hokudai.ac.jp Search for other works by this author on: Oxford Academic Google Scholar T. Shimizu, T. Shimizu Department of Dermatology, Hokkaido University Graduate School of Medicine, N 15 W 7, Kitaku, Sapporo 060‐8638, Japan E‐mail: aberi@med.hokudai.ac.jp Search for other works by this author on: Oxford Academic Google Scholar A. Tsuji, A. Tsuji Department of Dermatology, Hokkaido University Graduate School of Medicine, N 15 W 7, Kitaku, Sapporo 060‐8638, Japan E‐mail: aberi@med.hokudai.ac.jp Search for other works by this author on: Oxford Academic Google Scholar T. Matsumura, T. Matsumura Department of Dermatology, Hokkaido University Graduate School of Medicine, N 15 W 7, Kitaku, Sapporo 060‐8638, Japan E‐mail: aberi@med.hokudai.ac.jp Search for other works by this author on: Oxford Academic Google Scholar H. Shimizu H. Shimizu Department of Dermatology, Hokkaido University Graduate School of Medicine, N 15 W 7, Kitaku, Sapporo 060‐8638, Japan E‐mail: aberi@med.hokudai.ac.jp Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 147, Issue 6, 1 December 2002, Pages 1273–1275, https://doi.org/10.1046/j.1365-2133.2002.05000_8.x Published: 01 December 2002
Intravitreal Aflibercept Injection for Macular Edema Resulting from Central Retinal Vein Occlusion
Authors: Jean-François Korobelnik, Frank G. Holz, Johann Roider, Yuichiro Ogura, Christian Simader, Ursula Schmidt-Erfurth, Katrin Lorenz, Miki Honda, Robert Vitti, Alyson J. Berliner, Florian Hiemeyer, Brigitte Stemper, Oliver Zeitz, Rupert Sandbrink
Journal: Ophthalmology (2013)
P508Pharmacological activation of the soluble guanylate cyclase inhibits pressure overload-induced cardiac hypertrophy
Authors: T Radovits, C Matyas, A Olah, BT Nemeth, L Hidi, M Ruppert, A Lux, G Merkely, D Kellermayer, B Merkely
Journal: Cardiovascular Research (2014)

Purpose: Pathological cardiac hypertrophy is observed in pressure overload of the left ventricle. Elevated intracellular cGMP-levels have been reported to prevent the development of pathological myocardial hypertrophy. We investigated the effects of chronic activation of the cGMP producing enzyme, soluble guanylate cyclase (sGC) by cinaciguat in a rat model of pressure overload-induced cardiac hypertrophy. Methods: We performed aortic banding (AB) to evoke pressure overload-induced cardiac hypertrophy in our rats. Sham operated animals served as controls. Experimental groups were treated with 10 mg/kg/day cinaciguat (Cin) or with placebo (Co) p.o., respectively. Development of cardiac hypertrophy was investigated by echocardiography. We performed left ventricular (LV) pressure-volume analysis with a pressure-conductance microcatheter to assess cardiac function. In addition to our functional experiments, histological and molecular biological measurements were carried out. Results: Echocardiography showed marked myocardial hypertrophy in the AB-Co group (left ventricular mass index (LVMi): 3.15±0.09 AB-Co vs. 2.13±0.04g/ttkg Sham-Co) which was verified by post mortem investigation of the hearts (heart weight/tibial length ratio (HW/TL): 0.384±0.015 AB-Co vs. 0.293±0.008g/cm Sham-Co) and by histology (cardiomyocyte diameter (CD): 17.37±0.04 AB-Co vs. 14.55±0.12μm Sham-Co). Increased left ventricular dimensions (left ventricular end-diastolic volume: 414±19 AB-Co vs. 341±19μl Sham-Co) were observed while ejection fraction and fractional shortening remained unchanged. Cinaciguat did not alter blood pressure but effectively attenuated left ventricular hypertrophy (LVMi: 2.64±0.06g/ttkg, HW/TL: 0.339±0.009g/cm, CD: 15.08±0.10μm, p <0,05 vs. AB-Co). Conclusions: Our results demonstrate that chronic stimulation of the NO-cGMP signalling by pharmacologically activating soluble guanylate cyclase might be a novel therapeutic approach in the prevention of pathological myocardial hypertrophy.
Sequential changes in vital signs and acid-base and blood-gas profiles in Pneumocystis carinii pneumonitis in children with cancer. Basis for a scoring system to identify patients who will require ventilatory support.
Authors: S K Sanyal, F S Chebib, J R Gilbert, W T Hughes
Journal: American Journal of Respiratory and Critical Care Medicine (1994)

Early reliable identification of patients with Pneumocystis carinii pneumonia (PCP) who will require ventilatory support would be desirable. To develop a predictive system to meet this need, we studied, prospectively, the sequential alterations in vital signs and acid-base and blood-gas profiles associated with this disease in 55 children with cancer, 29 of whom did not require ventilatory support (Group I) and 26 who did (Group II). None of the patients had acquired immunodeficiency syndrome (AIDS). On admission to the hospital the only feature that distinguished patients in Group I from those in Group II was the mean (+/- SD) respiratory rate (38.7 +/- 2.1 versus 49.1 +/- 3.5 breaths/min, p < 0.02). By 12 h after admission there was a significant difference in the partial pressure of oxygen (PaO2) between Groups I and II (75.1 +/- 3.2 mg Hg versus 65.4 +/- 3.1 mm Hg, p < 0.05), and also in the two groups' inspired fraction of oxygen (FIO2; 24.9 +/- 0.54% versus 29.6 +/- 1.6%, p < 0.01). Both alterations, as well as tachypnea, persisted for the remainder of the study period. The maximum FIO2 did not exceed 45% in Group I, and by 60 h after admission to the hospital, all patients in this group had persistent increases in PaO2 that exceeded 80 mm Hg, permitting decreases in FIO2 to that of room air. In Group II, hypoxemia was refractory despite an increase in FIO2 to 50%, at which point ventilatory support was begun (at a mean of 81.1 +/- 32.3 h after admission).(ABSTRACT TRUNCATED AT 250 WORDS)
In Vivo Proof of Concept of Adoptive Immunotherapy for Hepatocellular Carcinoma Using Allogeneic Suicide Gene-modified Killer Cells
Authors: Céline Leboeuf, Laurent Mailly, Tao Wu, Gaetan Bour, Sarah Durand, Nicolas Brignon, Christophe Ferrand, Christophe Borg, Pierre Tiberghien, Robert Thimme, Patrick Pessaux, Jacques Marescaux, Thomas F. Baumert, Eric Robinet
Journal: Molecular Therapy (2013)

Cell therapy based on alloreactivity has completed clinical proof of concept against hematological malignancies. However, the efficacy of alloreactivity as a therapeutic approach to treat solid tumors is unknown. Using cell culture and animal models, we aimed to investigate the efficacy and safety of allogeneic suicide gene-modified killer cells as a cell-based therapy for hepatocellular carcinoma (HCC), for which treatment options are limited. Allogeneic killer cells from healthy donors were isolated, expanded, and phenotypically characterized. Antitumor cytotoxic activity and safety were studied using a panel of human or murine HCC cell lines engrafted in immunodeficient or immunocompetent mouse models. Human allogeneic suicide gene-modified killer cells (aSGMKCs) exhibit a high, rapid, interleukin-2-dependent, and non-major histocompatibility complex class I-restricted in vitro cytotoxicity toward human hepatoma cells, mainly mediated by natural killer (NK) and NK-like T cells. In vivo evaluation of this cell therapy product demonstrates a marked, rapid, and sustained regression of HCC. Preferential liver homing of effector cells contributed to its marked efficacy. Calcineurin inhibitors allowed preventing rejection of allogeneic lymphocytes by the host immune system without impairing their antitumor activity. Our results demonstrate proof of concept for aSGMKCs as immunotherapy for HCC and open perspectives for the clinical development of this approach.
Effects of local delivery of d-amino acids from biofilm-dispersive scaffolds on infection in contaminated rat segmental defects
Authors: Carlos J. Sanchez, Edna M. Prieto, Chad A. Krueger, Katarzyna J. Zienkiewicz, Desiree R. Romano, Catherine L. Ward, Kevin S. Akers, Scott A. Guelcher, Joseph C. Wenke
Journal: Biomaterials (2013)
DELAYED UNION AND UNUNITED FRACTURES.
Authors: CASPAR W. SHARPLES
Journal: JAMA (1905)

Norris has made general and elaborate classifications of these conditions, which are, in substance, as follows: <h3>Class 1.</h3> —Delayed union, callus forms and union is not rendered complete by ossification. <h3>Class 2.</h3> —Entire want of union, the ends of the bones are diminished in size, there is motion between the fragments and the limit of this motion is usually small. <h3>Class 3.</h3> —With fragments small, rounded off, tapering and bound together by fibrous bands. <h3>Class 4.</h3> —Pseudarthrosis; a dense capsule seems to form around the ends of the bones; on opening this a fluid is found resembling synovial fluid. The ends are eburnated. By referring to numerous authors along about the fifties, I found a few notes in regard to the causation of ununited fractures. The principal ones correspond very clearly to our present ideas, and I am sure that this quotation from Velpeau places him and his opinion on
Euglena Light-Harvesting Complexes Are Encoded by Multifarious Polyprotein mRNAs that Evolve in Concert
Authors: Adam G. Koziol, Dion G. Durnford
Journal: Molecular Biology and Evolution (2007)

Light-harvesting complexes (LHCs) are a superfamily of chlorophyll- and carotenoid-binding proteins that are responsible for the capture of light energy and its transfer to the photosynthetic reaction centers. Unlike those of most eukaryotes, the LHCs of Euglena gracilis are translated from large mRNAs, producing polyprotein precursors consisting of multiple concatenated LHC subunits that are separated by conserved decapeptide linkers. These precursors are posttranslationally targeted to the chloroplast and cleaved into individual proteins. We analyzed expressed sequence tags from Euglena to further characterize the structural features of the LHC polyprotein-coding genes and to examine the evolution of this multigene family. Of the 19 different LHC transcriptional units we detected, 17 encoded polyproteins composed of both tandem and nontandem repeats of LHC subunits; organizations that likely occurred through unequal crossing-over. Of the 2 nonpolyprotein-encoding LHC transcripts detected, 1 evolved from the truncation of a polyprotein-coding gene. Duplication of LHC polyprotein-coding genes was particularly important in the LHCI gene family where multiple paralogous sequences were detected. Intriguingly, several of the individual LHC-coding subunits both within and between transcriptional units appeared to be evolving in concert, suggesting that gene conversion has been a significant mechanism for LHC evolution in Euglena.
Cold Lesions on Bone Scan in Pediatric Neoplasms
Authors: TINA WEINGRAD, SYDNEY HEYMAN, ABASS ALAVI
Journal: Clinical Nuclear Medicine (1984)

A retrospective examination of the bone scans of 425 pediatric oncology patients was undertaken to determine the incidence of photon-deficient (cold) lesions in this population. Eight patients (1.8%) had cold lesions due to a wide variety of tumors. Of the tumor types, six had not been previously reported to give cold lesions on bone scan. The appearance of the radiograph at the site of the cold lesion was normal in five of the eight patients. All but one of the patients had "hot spots" as well as a cold lesion. Follow-up scans showed resolution of the cold lesions in two cases and a change from cold to hot in one case. A review of the literature revealed eight cases of cold lesions on bone scan due to tumor in pediatric patients. The previous reports included five patients with neuroblastoma and three with osteosarcoma.
Neutrophils degrade subendothelial matrices in the presence of alpha-1-proteinase inhibitor. Cooperative use of lysosomal proteinases and oxygen metabolites.
Authors: S J Weiss, S Regiani
Journal: Journal of Clinical Investigation (1984)

Triggered neutrophils rapidly degraded labeled matrices secreted by cultured, venous endothelial cells via a process dependent on elastase but not oxygen metabolites. In the presence of high concentrations of alpha-1-proteinase inhibitor, the ability of the stimulated neutrophil to solubilize the matrix was impaired. However, at lower concentrations of alpha-1-proteinase inhibitor the neutrophil could enhance the degradative potential of its released elastase by a H2O2-dependent process. Coincident with this increase in matrix damage, the stimulated neutrophil destroyed the elastase inhibitory activity of the alpha-1-proteinase inhibitor via a catalase-inhibitable process. The ability of the triggered neutrophil to solubilize the matrix in the presence of alpha-1-proteinase inhibitor was unaffected by superoxide dismutase or hydroxyl radical scavengers but was markedly impaired by catalase, azide, or hypochlorous acid scavengers. We conclude that neutrophils can cooperatively use an oxidant with characteristics similar, if not identical, to hypochlorous acid and the lysosomal proteinase elastase to negate the protective effects of alpha-1-proteinase inhibitor in order to attack the subendothelial matrix.
Improved targeting of JAK2 leads to increased therapeutic efficacy in myeloproliferative neoplasms
Authors: Neha Bhagwat, Priya Koppikar, Matthew Keller, Sachie Marubayashi, Kaitlyn Shank, Raajit Rampal, Jun Qi, Maria Kleppe, Hardik J. Patel, Smit K. Shah, Tony Taldone, James E. Bradner, Gabriela Chiosis, Ross L. Levine
Journal: Blood (2014)
The Regulatory Challenge of Electronic Cigarettes
Authors: Neal L. Benowitz, Maciej L. Goniewicz
Journal: JAMA (2013)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Malignant argentaffinoma with carcinoid syndrome and hypoglycaemia.
Authors: A R Adamson, D G Grahame-Smith, V Bogomoletz, D S Maw, N G Rothnie
Journal: BMJ (1971)

liver was enlarged to 5 cm below the costal margin and was hard and nodular.The eyes were dry and there was loss of transparency of the conjunctivae, with Bitot's spots.The retinae had a yellowish cast, but the fundi were otherwise normal.The serum bilirubin was 19 4 mg/100 ml, and the serum carotene was 10 g,g 100 ml.After eight daily injections of vitamin A dark-adaptation was much improved, and within two weeks he was able clearly to distiinguish objects in the dusk, and his ability to read print was completely normal.
Bilateral Idiopathic Chondrolysis of the Hip
Authors: IRINA RACHINSKY, LUDMILA BOGUSLAVSKY, EUGENE COHEN, YANCU HERTZANU, SOPHIE LANTSBERG
Journal: Clinical Nuclear Medicine (2000)

A case of bilateral idiopathic chondrolysis of the hip is presented. Chondrolysis is a process characterized by progressive necrosis of the hyaline cartilage of the acetabulum and femoral head, resulting in secondary joint space narrowing and stiffness. A 14-year-old boy was followed during a 2-year period, and the diagnostic values of the different imaging methods (radiography, magnetic resonance imaging [MRI], and bone scintigraphy) were evaluated. Scintigraphic evidence of marked periarticular uptake and premature fusion of the epiphysis of the greater trochanter was a reliable indicator of chondrolysis. Furthermore, the bone scan could precede other imaging methods (radiography and MRI) in the diagnosis of the progression of the pathologic process, status of the remodeling activity, and early involvement of an opposite joint. Given the high sensitivity of bone scans and the high specificity of radiographic and MRI examinations in the diagnosis of acute chondrolysis of the hip, all three methods are valuable and should be used as complementary diagnostic tools.
Bill Gates says rich governments are failing the developing world
Authors: Paul Ress
Journal: BMJ (2005)

Bill Gates, one of the world's leading industrialists, this week denounced the “tragic, incredible inequity between the health of the people in the developing world and the health of those in the rest of the world” in an address to the World Health Assembly in Geneva. The majority of his audience were the health ministers of the world's poorest countries.

Mr Gates, who created a $200m (£110m; €160m) health foundation called “The Grand Challenges in …
COMPARISONS OF CORONARY ARTERY ENDOTHELIAL FUNCTION AFTER NOBORI AND XIENCE V STENT IMPLANTATION IN SWINE MODEL
Authors: Arihiro Sumida, Hiroyuki Nagai, Bill Gogas, Jinsheng Li, Dongming Hou, Spencer King, Jaipal Singh, Nicolas Chronos
Journal: Journal of the American College of Cardiology (2012)
99mTc-Sestamibi Using a Direct Conversion Molecular Breast Imaging System to Assess Tumor Response to Neoadjuvant Chemotherapy in Women With Locally Advanced Breast Cancer
Authors: David Mitchell, Carrie B. Hruska, Judy C. Boughey, Dietlind L. Wahner-Roedler, Katie N. Jones, Cindy Tortorelli, Amy Lynn Conners, Michael K. O’Connor
Journal: Clinical Nuclear Medicine (2013)

The objective of this study was to determine the ability of breast imaging with 99mTc-sestamibi and a direct conversion-molecular breast imaging (MBI) system to predict early response to neoadjuvant chemotherapy (NAC).Patients undergoing NAC for breast cancer were imaged with a direct conversion-MBI system before (baseline), at 3 to 5 weeks after onset, and after completion of NAC. Tumor size and tumor-to-background (T/B) uptake ratio measured from MBI images were compared with extent of residual disease at surgery using the residual cancer burden.Nineteen patients completed imaging and proceeded to surgical resection after NAC. Mean reduction in T/B ratio from baseline to 3 to 5 weeks for patients classified as RCB-0 (no residual disease), RCB-1 and RCB-2 combined, and RCB-3 (extensive residual disease) was 56% (SD, 0.20), 28% (SD, 0.20), and 4% (SD, 0.15), respectively. The reduction in the RCB-0 group was significantly greater than in RCB-1/2 (P = 0.036) and RCB-3 (P = 0.001) groups. The area under the receiver operator characteristic curve for determining the presence or absence of residual disease was 0.88. Using a threshold of 50% reduction in T/B ratio at 3 to 5 weeks, MBI predicted presence of residual disease at surgery with a diagnostic accuracy of 89.5% (95% confidence interval [CI], 0.64%-0.99%), sensitivity of 92.3% (95% CI, 0.74%-0.99%), and specificity of 83.3% (95% CI, 0.44%-0.99%). The reduction in tumor size at 3 to 5 weeks was not statistically different between RCB groups.Changes in T/B ratio on MBI images performed at 3 to 5 weeks following initiation of NAC were accurate at predicting the presence or absence of residual disease at NAC completion.
Doctors' leaders applaud NHS cash injection
Authors: G. Iacobucci
Journal: BMJ (2014)

Doctors’ leaders have welcomed the government’s commitment to boost spending on the UK health services by £2bn (€2.5bn; $3.1bn) next year and to ringfence £1bn to improve general practice premises over the next four years. The funding injection was announced by the chancellor of the exchequer, George Osborne, ahead of his autumn statement on Wednesday 3 December.

The chancellor said that the money was a “down payment” on the recent Five Year Forward View from NHS leaders, which called for an extra £8bn a year above inflation for the NHS in England by 2020.1

Around £1.5bn will be invested in frontline care across the United Kingdom (including around £300m for Wales, Scotland, and Northern Ireland). In England the £1.2bn will be allocated by NHS England to clinical commissioning …