A PROGRESS REPORT OF INVESTIGATIONS CONCERNED WITH THE EXPERIMENTAL TREATMENT OF HYPERTENSION WITH KIDNEY EXTRACTS
Authors: Irvine H. Page, O. M. Helmer, K. G. Kohlstaedt, G. F. Kempf, A. C. Corcoran, R. D. Taylor
Journal: Annals of Internal Medicine (1943)

Article1 January 1943A PROGRESS REPORT OF INVESTIGATIONS CONCERNED WITH THE EXPERIMENTAL TREATMENT OF HYPERTENSION WITH KIDNEY EXTRACTSIRVINE H. PAGE, M.D., O. M. HELMER, PH.D., K. G. KOHLSTAEDT, M.D., G. F. KEMPF, M.D., A. C. CORCORAN, M.D., R. D. TAYLOR, M.D.IRVINE H. PAGE, M.D., O. M. HELMER, PH.D., K. G. KOHLSTAEDT, M.D., G. F. KEMPF, M.D., A. C. CORCORAN, M.D., R. D. TAYLOR, M.D.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-18-1-29 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptAt this time last year we reported to you the reasons why we believe that certain extracts of normal kidneys contain a substance, or substances, which lowers arterial blood pressure in hypertensive dogs, rats and human beings.1 It was pointed out that one of the most striking effects of these extracts was their ability to reverse the retinal arterial lesions observed during the course of the malignant phase of hypertension. Their administration was also often associated with a rise in the usually depressed renal blood flow.Difficulties both in the preparation of the extract and in its use were numerous....Bibliography1. 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M., KOHLSTAEDT, K. G., KEMPF, G. F., and PAGE, I. H.: The assay of antipressor extracts of kidney by in vitro destruction of angiotonin, Fed. Proc., 1942, i, 114. Google Scholar7. Unpublished observations. Google Scholar8. TAYLORPAGE RMIH a. : The effect on cardiac output of renal extracts which lower arterial blood pressure in hypertensive patients, and of the pressor substances angiotonin, tyramine and methyl guanidine sulfate, Proc. Central Soc. Clin. Res., 1941, xiv, 16. Google Scholar8. CORCORANPAGE ACIH b. : Quantitative formulation of maximum urinary specific gravity, Jr. Mt. Sinai Hosp., 1938, viii, 459. Google Scholar9. GOLDRINGRANGESCHASISSMITH WHAHHW: Effective renal blood flow and functional excretory tubular mass in essential hypertension, Jr. Clin. Invest., 1938, xvii, 505. Google Scholar10. WILSONBYROM CFB: Renal changes in malignant hypertension, Lancet, 1939, i, 136. CrossrefGoogle Scholar11. 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MURPHYGRILLLANGENFELDKURTENGUENTHER FDJGPLJV: The use of kidney extract in controlling experimental renal hypertension and essential hypertension, Proc. Central Soc. Clin. Res., 1941, xiv, 16. Google Scholar22. MURPHY FD: Modern trends in treatment of hypertension, Wisconsin Med. Jr., 1942, xli, 199. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Indianapolis, Indiana*Read at the St. Paul meeting of the American College of Physicians April 21, 1942. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byEnzymes that Inactivate Vasoactive PeptidesSustained Depressor Effect of Renal Medullary Extract in the Normotensive RatHypertonieRenin und Hypertensin, physiologische oder pathologische Wirkstoffe?VASOCONSTRICTORS IN THE COMMON COLDPENICILLIN IN RHEUMATIC FEVERRENAL EXTRACTS IN HYPERTENSIONAngiotonin or Hypertensin 1 January 1943Volume 18, Issue 1Page: 29-42KeywordsBlood pressureHypertensionKidneysLesionsRenal circulation ePublished: 1 December 2008 Issue Published: 1 January 1943 PDF downloadLoading ...