SULFADIAZINE; A STUDY OF ITS EFFECT ON HEMOLYTIC STREPTOCOCCI
Authors: Charles H. Rammelkamp, Chester S. Keefer
Journal: Annals of Internal Medicine (1942)

Article1 April 1942SULFADIAZINE; A STUDY OF ITS EFFECT ON HEMOLYTIC STREPTOCOCCICHARLES H. RAMMELKAMP, M.D., CHESTER S. KEEFER, M.D., F.A.C.P.CHARLES H. RAMMELKAMP, M.D.Search for more papers by this author, CHESTER S. KEEFER, M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-16-4-659 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptIn view of the fact that patients with hemolytic streptococcal infections who are treated with sulfanilamide often continue to have a prolonged and protracted illness, it is desirable to search for more effective chemotherapeutic agents. Recently, another sulfonamide derivative, sulfadiazine, has been described by Roblin, Williams, Winnek, and English.1In preliminary studies it was found to protect mice against hemolytic streptococcal and pneumococcal infections.2Later,3it was reported that it was superior to either sulfanilamide or sulfapyridine in the treatment of experimental infections of mice due to the hemolytic streptococcus. It was pointed out that the animals receiving sulfadiazine had...References1. ROBLINWILLIAMSWINNEKENGLISH ROJHPSJP: Chemotherapy. II. Some sulfanilamido heterocycles, Jr. Am. Chem. Soc., 1940, lxii, 2002. CrossrefGoogle Scholar2. ROBLINWINNEK ROPS: Chemotherapy. I. Substituted sulfanilamidopyridines, Jr. Am. Chem. Soc., 1940, lxii, 1999. CrossrefGoogle Scholar3. FEINSTONEWILLIAMSWOLFHUNTINGTONCROSSLEY WHRDRTEML: The toxicity, absorption and chemotherapeutic activity of 2-sulfanilamidopyrimidine (sulfadiazine), Bull. Johns Hopkins Hosp., 1940, lxvii, 427. Google Scholar4. PETERSONSTRAUSSTAYLORFINLAND OLEFHM: Absorption, excretion and distribution of sulfadiazine (2-sulfanilamidopyrimidine), Am. Jr. Med. Sci., 1941, cci, 357. CrossrefGoogle Scholar5. SADUSKTREDWAY JFJB: Observations on the absorption, excretion, diffusion, and acetylation of sulfadiazine in man, Yale Jr. Biol. and Med., 1941, xiii, 539. Google Scholar6. REINHOLDFLIPPINSCHWARTZDOMM JGHFLAH: The absorption, distribution, and excretion of 2-sulfanilamido pyrimidine (sulfapyrimidine, sulfadiazine) in man, Am. Jr. Med. Sci., 1941, cci, 106. CrossrefGoogle Scholar7. RAMMELKAMPKEEFER CHCS: Sulfathiazole: effect on Staphylococcus aurcus in vitro, Proc. Soc. Exper. Biol. and Med., 1940, xliii, 664. CrossrefGoogle Scholar8. KEEFERRANTZ CSLA: Sulfanilamide: a study of its mode of action on hemolytic streptococci, Arch. Int. Med., 1939, lxiii, 957. CrossrefGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Boston, Massachusetts*Received for publication June 9, 1941.(Read before the Association of American Physicians, Atlantic City, N. J., May 6, 1941.)From the Evans Memorial, Massachusetts Memorial Hospitals, and the Department of Medicine, Boston University School of Medicine, Boston, Massachusetts. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 April 1942Volume 16, Issue 4Page: 659-665KeywordsChemotherapeutic agentsHospital medicineStreptococcal infectionsStreptococcusSulfonamide ePublished: 1 December 2008 Issue Published: 1 April 1942 PDF downloadLoading ...