tbuckley/cabot-search huggingface dataset:
Incidental lymphoma during sentinel lymph node biopsy for breast cancer.
Authors: J. P. Fox, V. P. Grignol, J. Gustafson, P. Cheng, R. Weighall, J. Ouellette, M. Hellan, Y. Dowdy, P. Termuhlen
Journal: Journal of Clinical Oncology (2010)

e11083 Background: Sentinel lymph node biopsy (SLNB) is the recommended procedure for early stage breast cancer to identify nodal disease in the axilla. While metastatic adenocarcinoma is sought, the coexistence of lymphoma has been reported. This study was conducted to assess the frequency that lymphoma is diagnosed in the sentinel lymph node (SLN) for breast cancer staging. Methods: We conducted a retrospective chart review of patients seen and treated for breast cancer at a community-based surgical oncology practice from January 2006–June 2009 who underwent SLNB. Pertinent tumor data and patient information was collected. Results: 321 patients were included. All patients were female. Average age was 60.3 years. 320 SLNB was performed (1 attempted) with an average of 3.1 nodes obtained/procedure. Pathology results were: benign or reactive (226), metastatic breast cancer (67), micrometastasis (19), isolated tumor cells (8), and lymphoma (5). The average age of lymphoma patients was 68.2 years. None were previously diagnosed with lymphoma, leukemia, or had undergone radiation therapy. All patients had stage 0-IIA DCIS or IDC as their primary breast cancer without breast lymphoma. Small lymphocytic lymphoma (3), aggressive B- cell lymphoma (1), and low-grade B cell non-Hodgkins lymphoma (1) were the subtypes identified in the axillary node. One patient with metastatic breast cancer and lymphoma in the SLNs went on for completion axillary dissection without further nodes positive for metastatic breast cancer. One patient required chemotherapy for their lymphoma. To date, no patient has developed signs of recurrent breast cancer. Conclusions: While considered a rare finding, concurrent lymphoma was diagnosed in 1.6% of patients in this study. The clinical concern is that the finding of lymphoma in the SLN may prevent an accurate SLNB for breast cancer and therefore affect staging. Further prospective evaluation should be conducted to gain a better understanding of the true incidence and affect on staging in breast cancer. No significant financial relationships to disclose.
Osteogenic Sarcoma in Children
Authors: Alvin B. Hayles
Journal: JAMA (1960)

One hundred twenty-nine children (67 girls and 62 boys) less than 16 years of age with pathologically verified osteogenic sarcoma have been seen during the 50-year period, 1909 through 1958. Adequate follow-up information is available on 126 of the patients. The survival rates among children with osteogenic sarcoma are influenced by the degree of malignancy and location of the tumor and the type of therapy administered. Amputation was the primary form of therapy in 101 patients; radiation, was the treatment given 15 patients; excision of the tumor was carried out in only 6. Seven patients were not treated. The authors believe that early amputation is the treatment of choice in patients whose tumors arise in the extremities and who do not manifest evidence of metastasis. No patient with a tumor arising at a site that precluded amputation survived five years, and only one patient treated with radiation therapy survived.
Internet drug trafficking needs international counter offensive
Authors: Rohit Sharma
Journal: BMJ (2001)

An international collaboration is needed to stamp out internet trafficking of narcotic drugs and psychotropic substances around the world, the International Narcotics Control Board has urged.

Some online companies advertise that they can provide prescription drugs without prescription or that their dispensing pharmacy can issue the prescription, said the control board in its annual report. Two internet pharmacies in Bangkok and one in Chiang Mai, Thailand, mainly serving the US market, were closed down between November 1999 and January 2000 after raids by Thai authorities with the close collaboration of US Drug Enforcement …
Review: Multicomponent nonpharmacologic interventions reduce incident delirium in inpatients
Authors: Calvin Hirsch
Journal: Annals of Internal Medicine (2015)

ACP Journal Club21 July 2015Review: Multicomponent nonpharmacologic interventions reduce incident delirium in inpatientsCalvin Hirsch, MDCalvin Hirsch, MDUniversity of California, Davis, Sacramento, California, USA (C.H.)Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/ACPJC-2015-163-2-004 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail Source CitationHshieh TT, Yue J, Oh E, et al. Effectiveness of multicomponent nonpharmacological delirium interventions: a meta-analysis. JAMA Intern Med. 2015;175:512-20. https://pubmed.ncbi.nlm.nih.gov/25643002Clinical Impact RatingsHospitalists: Geriatrics: References1. Yue J, Tabloski P, Dowal SL, et al. NICE to HELP: operationalizing National Institute for Health and Clinical Excellence guidelines to improve clinical practice. J Am Geriatr Soc. 2014;62:754-61. [PMID: 24697606] Google Scholar2. Zhang H, Lu Y, Liu M, et al. Strategies for prevention of postoperative delirium: a systematic review and meta-analysis of randomized trials. Crit Care. 2013;17:R47. [PMID: 23506796] Google Scholar3. Rothberg MB, Herzig SJ, Pekow PS, et al. Association between sedating medications and delirium in older inpatients. J Am Geriatr Soc. 2013;61:923-30. [PMID: 23631415] Google Scholar Author, Article, and Disclosure InformationAffiliations: University of California, Davis, Sacramento, California, USA (C.H.)This article was published at Annals.org on 7 July 2015. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 21 July 2015Volume 163, Issue 2Page: JC4KeywordsAntipsychoticsDeliriumFallsHearingInpatientsLength of stayQualitative studiesSleepSystematic reviewsVision ePublished: 21 July 2015 Issue Published: 21 July 2015 Copyright & PermissionsCopyright © 2015 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Targeted disruption of the biglycan gene leads to an osteoporosis-like phenotype in mice
Authors: Tianshun Xu, Paolo Bianco, Larry W. Fisher, Glenn Longenecker, Erica Smith, Steven Goldstein, Jeffrey Bonadio, Adele Boskey, Anne-Marie Heegaard, Beatrice Sommer, Kazuhito Satomura, Pedro Dominguez, Chengyan Zhao, Ashok B. Kulkarni, Pamela Gehron Robey, Marian F. Young
Journal: Nature Genetics (1998)
PRESENT DAY UNDESIRABLE TRENDS IN THE TRAINING OF PHYSICIANS AND OF TEACHERS OF INTERNAL MEDICINE
Authors: H A CHRISTIAN
Journal: Annals of Internal Medicine (1950)

Article1 September 1950PRESENT DAY UNDESIRABLE TRENDS IN THE TRAINING OF PHYSICIANS AND OF TEACHERS OF INTERNAL MEDICINEHENRY A. CHRISTIAN, M.D., M.A.C.P.HENRY A. CHRISTIAN, M.D., M.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-33-3-533 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptNo doubt it will seem presumptuous of me this afternoon to step out of the past to criticise, even gently, the ways of what to me is the younger generation of medical folk. However, I am going to be presumptuous and develop the thesis that today the usual work program of the resident staffs of our hospitals is defective in that it does not provide in adequacy that form of training calculated to develop interns and residents rapidly and steadily into well trained clinicians, and that at this period of their development there is undesirable emphasis placed on investigation as... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: *Presented at the Thirty-first Annual Session of the American College of Physicians, Boston, April 18, 1950. Nextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byThe Training of Interns and Residents 1 September 1950Volume 33, Issue 3Page: 533-543 ePublished: 1 December 2008 Issue Published: 1 September 1950 Copyright & PermissionsCopyright, 1950, by The American College of PhysiciansPDF downloadLoading ...
Effect of Injected Lyophilized Tumor and Trypan Blue on Host Resistance to Tumor Grafts&lt;xref ref-type="fn" rid="fn1"&gt;&lt;sup&gt;2&lt;/sup&gt;&lt;/xref&gt;
Authors: Nathan Kaliss, Paulo R. F. Borges
Journal: JNCI Journal of the National Cancer Institute (1952)

Journal Article Effect of Injected Lyophilized Tumor and Trypan Blue on Host Resistance to Tumor Grafts Get access Nathan Kaliss, Nathan Kaliss Roscoe B. Jackson Memorial Laboratory, Bar Harbor, Maine Search for other works by this author on: Oxford Academic PubMed Google Scholar Paulo R. F. Borges Paulo R. F. Borges Roscoe B. Jackson Memorial Laboratory, Bar Harbor, Maine Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 13, Issue 2, October 1952, Pages 343–347, https://doi.org/10.1093/jnci/13.2.343 Published: 01 October 1952 Article history Received: 26 March 1952 Published: 01 October 1952
Spatial extent of pigment epithelial detachments in age-related macular degeneration11The authors have no proprietary interest in the development or marketing of this or a competing instrument and/or software.
Authors: Christian Kunze, Ann E. Elsner, Eva Beausencourt, Lúcio Moraes, M.Elizabeth Hartnett, Clement L. Trempe
Journal: Ophthalmology (1999)
Effect of interleukin-2 on the pool of latently infected, resting CD4+ T cells in HIV-1-infected patients receiving highly active anti-retroviral therapy
Authors: Tae-Wook Chun, Delphine Engel, Stephanie B. Mizell, Claire W. Hallahan, Maria Fischette, Sohee Park, Richard T. Davey, Mark Dybul, Joseph A. Kovacs, Julia A. Metcalf, JoAnn M. Mican, M. Michelle Berrey, Lawrence Corey, H. Clifford Lane, Anthony S. Fauci
Journal: Nature Medicine (1999)
Abstract 2476: A novel NUT translocation partner binds to BRD4 and is necessary for the blockade of differentiation in NUT midline carcinoma
Authors: Erica Walsh, Simone Kuhnle, Shaila Rahman, Madeleine Lemieux, Peter Howley, Christopher French
Journal: Cancer Research (2014)

Abstract NUT midline carcinoma (NMC) is an aggressive type of squamous cell carcinoma that typically harbors BRD4/3-NUT fusion oncogenes which encode chimeric proteins that block differentiation and maintain tumor growth. However, in 30% of cases NUT is fused to yet to be identified non-BRD gene(s). Using RNA sequencing, we identified a novel gene fused to NUT in a NMC cell line (1221), fusing a novel 5′ coding sequence to the NUT gene. Like Brd4/3, this gene encodes a protein that is also involved in epigenetic regulation, and we find that siRNA knockdown of this protein leads to differentiation of the 1221 cells as well as of three BRD4-NUT-positive NMC cell lines. We have established that the novel NUT fusion protein encoded by this translocated gene binds to BRD4. We have mapped the regions of Brd4 and of the novel fusion protein involved in complex formation and are exploring whether association of the novel protein with Brd4 is required for the blockade of differentiation in NMC. Differentiation of TC-797 cells induced by knockdown of BRD4-NUT is abrogated by enforced expression of the novel NUT-fusion gene. Together, these findings identify a novel BRD4-NUT-interacting protein whose expression is required for the maintenance of the undifferentiated state in NMC, and when fused to NUT, is oncogenic and can recapitulate the function of BRD4-NUT to block differentiation. Citation Format: Erica Walsh, Simone Kuhnle, Shaila Rahman, Madeleine Lemieux, Peter Howley, Christopher French. A novel NUT translocation partner binds to BRD4 and is necessary for the blockade of differentiation in NUT midline carcinoma. [abstract]. In: Proceedings of the 105th Annual Meeting of the American Association for Cancer Research; 2014 Apr 5-9; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2014;74(19 Suppl):Abstract nr 2476. doi:10.1158/1538-7445.AM2014-2476
Pulmonary hypertension and right ventricular impairment in patients with interstitial pneumonia
Authors: Nina Karoli, Andrey Rebrov
Journal: European Respiratory Journal (2011)

There is little date about frequency of pulmonary hypertension (PH) and right ventricular (RV) impairment in patients with idiopathic interstitial pneumonia (IIP). In this work we examined the prevalence PH in these disorders using noninvasive cardiopulmonary evaluation.  40 patients (aged 50,33±2,55) with IIP have been studied in early period after IIP diagnosed. Criteria of exception were the clinical displays heart disease, arterial hypertension. Control group have made 14 normotensive volunteers (aged 47,57±1,86). All patients were studied using realtime, phased array, two-dimensional Doppler echocardiography. The pulmonary artery systolic pressure (SP) was calculated as the sum of the transtricuspid pressure gradient and the right atrial pressure.   Results:  Pulmonary hypertension (SP>35 mm Hg) is revealed at 15 patients with IIP and SP>40 mm Hg – at 7 (17.5%). Doppler-estimated SP at the patients with IIP exceeded SP at the healthy persons (33,24±1,97 mm Hg and 25,61±1,18 mm Hg, p  We noted correlations between SP and dyspnoe intensity (scale MRS) (r=0,63, p   Conclusion:  Pulmonary hypertension and right ventricular abnormalities is common in patients with IIP.
Abstract 16881: NOX Isoforms and Development of Abdominal Aortic Aneurysm
Authors: Kin L Siu, Hua Cai
Journal: Circulation (2014)

Oxidative stress plays an important role in the formation of abdominal aortic aneurysm (AAA), and we have recently shown a causal role of uncoupled eNOS in this disease. While others and we have also shown that NADPH oxidase (NOX) lie upstream of uncoupled eNOS, the specific isoforms(s) and role that they play in AAA has not been examined. In this study, we used a recently established model of AAA, the Ang II infused hph-1 mice, to examine the specific role of the major isoforms of NOX in the development of AAA. We generated double knockouts of hph-1-NOX1 and hph-1-NOX2, and also inhibited NOX4 expression in hph-1 animals with in vivo RNAi. Ang II was infused into the animals for 2 weeks using an osmotic pump. The results show that the incidence rate of AAA substantially dropped from 76% in Ang II infused hph-1 mice to 4% and 16% in hph-1-NOX1 and hph-1-NOX2 double knockouts, respectively, while hph-1-NOX4 siRNA animals did not have significantly different incidence (83%). By week 2, the sizes of abdominal aortas of the hph-1-NOX1 and hph-1-NOX2 double knockouts, determined by ultrasound analyses, were significantly smaller at 1.3±0.08 and 1.4±0.08 mm2, respectively, when compared to hph-1 alone, at 3.1±0.27 mm2. Furthermore, aortic nitric oxide and H4B bioavailability were markedly improved in the double knockouts, while the total superoxide production and eNOS uncoupling activity were markedly reduced. These effects seemed attributed to an endothelial cell specific improvement in the expression and activity of dihydrofolate reductase (DHFR), a salvage enzyme for H4B whose deficiency has been shown to induce eNOS uncoupling and AAA formation in both hph-1 and apoE null animals. Taken together, these data indicate that NOX isoforms 1 or 2 lies upstream of DHFR deficiency and eNOS uncoupling to induce AAA formation. These data once again demonstrate the importance of uncoupled eNOS in the development of AAA, and a novel role of NOX1/2 isoforms in the process. These findings may facilitate new therapeutic options for the treatment of the disease.
Charles Heidelberger 1920–1983
Authors: Vincent T. DeVita, Jr., M.D.
Journal: JNCI Journal of the National Cancer Institute (1983)

Journal Article Charles Heidelberger 1920–1983 Get access Vincent T. DeVita, Jr., M.D. Vincent T. DeVita, Jr., M.D. Director National Cancer Institute, Bethesda, Maryland 20205 Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 71, Issue 2, August 1983, Page 225, https://doi.org/10.1093/jnci/71.2.225 Published: 01 August 1983
RAT LIVER PARENCHYMAL CELL FUNCTION DURING AZO DYE CARCINOGENESIS.
Authors: Claude Watters, Antonio Cantero
Journal: Cancer Research (1965)

Since azo dye hepatocarcinogenesis involves the parenchymal cells, rose bengal chromoexcretion, a property of the parenchymal cells, was investigated in rats during feeding of 4-dimethylaminoazobenzene, a carcinogen, and 2-methyl-4-dimethylaminoazobenzene (2-Me-DAB), a noncarcinogen. These studies showed that both hepatic rose bengal uptake and excretion are reduced in rats fed the carcinogen. In the rats fed the noncarcinogen, however, there was a normal hepatic rose bengal uptake and only a slight increase in the excretion of rose bengal. These results were related to a decrease in rat liver parenchymal cell function during azo dye hepatocarcinogenesis and reflected the changes in liver morphology produced by the carcinogen.
Neurofeedback, Self-Regulation, and Brain Imaging: Clinical Science and Fad in the Service of Mental Disorders
Authors: Robert T. Thibault, Michael Lifshitz, Niels Birbaumer, Amir Raz
Journal: Psychotherapy and Psychosomatics (2015)

Neurofeedback draws on multiple techniques that propel both healthy and patient populations to self-regulate neural activity. Since the 1970s, numerous accounts have promoted electroencephalography-neurofeedback as a viable treatment for a host of mental disorders. Today, while the number of health care providers referring patients to neurofeedback practitioners increases steadily, substantial methodological and conceptual caveats continue to pervade empirical reports. And yet, nascent imaging technologies (e.g., real-time functional magnetic resonance imaging) and increasingly rigorous protocols are paving the road towards more effective applications and a better scientific understanding of the underlying mechanisms. Here, we outline common neurofeedback methods, illuminate the tenuous state of the evidence, and sketch out future directions to further unravel the potential merits of this contentious therapeutic prospect.
8-Azaguanine-Resistant Melanoma Cells In Vitro and In Vivo2
Authors: L. M. Pasztor, F. Hu, L. Stankova, R. Bigley
Journal: JNCI Journal of the National Cancer Institute (1974)

A murine malignant melanoma cell line, PAZG, resistant to 300 µg 8-azaguanine (AZG)/ml was isolated from mass cultures of B16 cells exposed to increasing analogue doses for more than 2 years in vitro. PAZG cells proliferated in medium containing high AZG concentrations and, because of a complete deficiency in hypoxanthineguanine phosphoribosyltransferase (HGPRT), did not incorporate exogenous guanine or hypoxanthine. Three observations supported the hypothesis that this enzyme deficiency was a stable, genetic cell characteristic: 1) PAZG cells either transferred to, and subcultured for 76 days in, medium lacking AZG or passaged through host animals still retained resistance to the analogue; 2) no revertants were found in 107 resistant cells; and 3) PAZG cells, fused with murine cells resistant to 5-bromodeoxyuridine and lacking thymidine kinase, formed hybrids which contained active HGPRT as well as thymidine kinase and proliferated in medium containing hypoxanthine, aminopterin, thymidine, and glycine. Studies of features such as morphology, karyology, and tumorigenicity failed to disclose any detectable differences between AZG-sensitive and AZG-resistant cell lines.
Abstract 16430: Early Urine Sodium Response After Ambulatory Diuretic Bolus to Avoid Heart Failure Hospitalization
Authors: Laura Burpee, Akshay Desai, Jennifer Smallwood, Michelle Young, Lynne Stevenson, Irene Cooper, Kristina Navarro-Velez, Elaine Shea, Craig Stevens, Cindy Weiffenbach, Joanne Weintraub, Mandeep Mehra
Journal: Circulation (2014)

Introduction: Ambulatory heart failure management may increasingly include administration of intravenous diuretics in an outpatient setting, but it is difficult to know when response will be adequate to avoid hospitalization. Hypothesis: We assessed whether a high initial urine sodium (Na) after an intravenous diuretic bolus would predict net urine output &gt; 1 liter after 3 hours of diuretic infusion, performed in an ACTIVE (Ambulatory Cardiac Triage, InterVention, and Education) unit where a nurse and pharmacist also provided heart failure education. Methods and Results: The unit accepted patients with chronic heart failure referred with symptomatic fluid overload without severe decompensation, and prescribed loop diuretic bolus and infusion dosed from an internal algorithm based on daily oral dose. Urine output was &gt; 1 liter after 3 hours in 77% of patients with urine Na response &gt; 100 mmol/L, in 69% with urine Na 61-100, and only 23% with initial urine Na &lt; 60 mmol/L. Baseline renal function was better in patients with higher urine Na after diuretic therapy. Conclusion: In conclusion, we can anticipate at least 1 liter diuresis in most patients with initial urine Na &gt; 60 mmol/L after bolus diuretic. Patients with urine Na &gt; 100 also have significantly lower 30 day ED and admission rates after outpatient diuretic infusion. Patients with low urine Na response may still have diuresis but may need more prolonged intervention or revision of goals of care.