tbuckley/cabot-search huggingface dataset:
Philadelphia General Hospital
Authors: Susan M. Beatty
Journal: JAMA (1988)

<h3>To the Editor.</h3> —In Dr Goldberg's<sup>1</sup>letter concerning the effects of the demise of Philadelphia General Hospital,<sup>2</sup>he states that "it appears that all patients in Philadelphia, regardless of economic status, are adequately cared for without hesitation at the city's numerous private hospitals." While we wish that were the case, a survey performed by medical students at the University of Pennsylvania provides evidence to the contrary. Last spring, to identify the health care needs of homeless and indigent people in west Philadelphia, students carried out standardized personal interviews with attendees of local soup kitchen suppers on five consecutive weeknights. Of approximately 120 attendees, 99 consented to be interviewed and 97 interviews were completed. Sadly, 16 of the 97 reported that they had recently been turned away from area hospitals because they could not pay for medical services. Furthermore, some claimed that they did not seek care when they
Combination chemotherapy and photodynamic therapy of targetable N-(2-hydroxypropyl)methacrylamide copolymer–doxorubicin/mesochlorin e6-OV-TL 16 antibody immunoconjugates
Authors: J.-G. Shiah, Y. Sun, P. Kopečková, C.M. Peterson, R.C. Straight, J. Kopeček
Journal: Journal of Controlled Release (2001)
The Heterodimeric Assembly of the CD94-NKG2 Receptor Family and Implications for Human Leukocyte Antigen-E Recognition
Authors: Lucy C. Sullivan, Craig S. Clements, Travis Beddoe, Darryl Johnson, Hilary L. Hoare, Jie Lin, Trevor Huyton, Emma J. Hopkins, Hugh H. Reid, Matthew C.J. Wilce, Juraj Kabat, Francisco Borrego, John E. Coligan, Jamie Rossjohn, Andrew G. Brooks
Journal: Immunity (2007)
INHERITANCE IN GUINEA PIGS OF THE SUSCEPTIBILITY TO SKIN SENSITIZATION WITH SIMPLE CHEMICAL COMPOUNDS
Authors: Merrill W. Chase
Journal: The Journal of Experimental Medicine (1941)

It has proved possible to set up lines of guinea pigs of significantly different susceptibilities towards a compound of simple structure, namely 2:4 dinitrochlorobenzene. This provides direct evidence that the type of sensitization under discussion is influenced by heredity.
A short-term analysis of permanent pacemaker implantation and utilization after cardiac surgery
Authors: Jo-ann E. Lynch, James B. Kirchhoffer, James R. Cook, Cynthia B. Kardos, Barry J. Karas, Laura L. Liucci, John A. Rousou, Joseph E. Flack, David W. Deaton, Daniel T. Engelman, Richard M. Engelman
Journal: Journal of the American College of Cardiology (2002)
TEMPORAL TRENDS IN THE POPULATION ATTRIBUTABLE RISK FOR CORONARY HEART DISEASE: ATHEROSCLEROSIS RISK IN COMMUNITIES STUDY
Authors: Susan Cheng, Brian Claggett, Andrew Correia, Amil Shah, Deepak Gupta, Hicham Skali, Gerardo Heiss, Aaron Folsom, Josef Coresh, Scott Solomon
Journal: Journal of the American College of Cardiology (2014)
Secondary T‐cell lymphoma in the setting of nodular lymphocyte predominance Hodgkin's disease
Authors: A. Tefferi, J. C. Wiltsie, P. J. Kurtin
Journal: American Journal of Hematology (1992)

Abstract Lymphocyte predominance Hodgkin's disease (LPHD) can be histogically subdivided into a nodular and diffuse variety. The two subtypes differ in immunophenotypic characteristics but have a similar long‐term clinical outcome. Nodular LPHD has immunophenotypic and histological characteristics suggestive of a B‐cell derived neoplastic process. Nodular LPHD is associated with an increased risk of secondary large cell lymphoma (LCL). Gene rearrangement studies in some of these cases have revealed a B‐cell clonal process, further supporting the association between nodular LPHD and the B‐cell system. In addition, it has been suggested that the apparent secondary LCL, at least in some cases, may represent a histologic progression of nodular LPHD. We report a unique case of T‐cell lymphoma, confirmed by T‐cell receptor gene rearrangement studies, which developed in the setting of nodular LPHD. Our observation demonstrates that the association of nodular LPHD and LCL is complex and that LCL developing in the context of nodular LPHD may be an independent secondary process sometimes involving T‐cell lymphomas. © 1992 Wiley‐Liss, Inc.
Diaria de Bello Carolino (Diary of the Caroline War)
Authors: Lester S. King
Journal: JAMA (1967)

When, in 1494, the French under Charles VIII invaded Italy, war was just as horrible as it is now, even though the forces of destruction were relatively minuscule. Alessandro Benedetti, a physician of Verona, gives us an eyewitness account of much of this campaign. Although the book is not written primarily from the medical standpoint, it exemplifies a physician's eye for detail and provides abundant descriptions of medical facets.  The book, primarily a historical document, serves a dual function. For scholars who work in Renaissance history it provides a carefully edited Latin text of an important document, with superb notes in the fine scholarly tradition that we expect from Dr. Schullian. The Latin text and the English translation are on facing pages. The translation is excellently done, idiomatic, highly readable, and yet splendidly faithful to the original. A long bibliography is of inestimable value.  For those who are not primarily
Textbook of Pediatric Emergency Medicine
Authors: Peter R. Holbrook
Journal: JAMA (1984)

Pediatric emergency medicine is a field beset with ambiguity. First there is the name. The field includes more than just emergencies, yet less than all of outpatient pediatrics. Perhaps the name should be pediatric emergency department medicine, for the common factor among the patients is that they come to the emergency room (ER). Some patients have problems for which ER management is the solution. For others the ER is but a conduit to the hospital bed, where perhaps a prolonged diagnostic or therapeutic stay ensues. And for others with a chronic illness, an acute exacerbation or an associated or unassociated problem brings the patient to the ER for episodic therapy. This array defines a second problem: What is the breadth and depth of the field? How much detail of which diseases constitutes adequate and appropriate coverage of the subject matter? Where does ER treatment end and inpatient treatment begin?  A
Acute ethanol dosage reduces the synthesis of smooth muscle contractile proteins in the small intestine of the rat.
Authors: V R Preedy, P Duane, T J Peters
Journal: Gut (1988)

The effects of an acute dose of ethanol (75 mmol/kg body weight; ip) on protein synthesis were investigated in the small intestine of the rat (n = 6). Control rats (n = 6) were injected with isovolumetric 0.15 mol/l NaCl, ip. After 2.5 h, fractional rates of protein synthesis (defined as the percentage of tissue protein renewed each day by synthesis and RNA efficiencies (defined as the amount of protein synthesised per unit RNA) were measured with a large flooding dose (0.3 Ci/mol; 150 mmol/l; 150 mumol/100 g body weight; iv) of [4(3)H]-phenylalanine. Rats were killed 10 minutes after injection of the isotope and portions of the small intestine were rapidly dissected and frozen. Tissues and plasma were processed for phenylalanine specific radioactivities to obtain fractional rates of protein synthesis or protein synthesis rates relative to RNA. Rates of protein synthesis in mixed tissue proteins fell approximately 15-25% (p ranged from less than 0.005 to greater than 0.05), in response to acute ethanol dosage. The decrease in the synthesis rates of the cytoplasmic protein fraction was similar (p less than 0.025). Proteins extracted from the smooth muscle contractile apparatus, however, showed a greater response to ethanol--that is, 40-50% inhibition in protein synthesis (p less than 0.001). It is therefore possible that the functional disturbances in the ethanol-exposed gut may be because of changes in smooth muscle protein turnover with decreased amounts of contractile apparatus.
<i>Notch3</i>Gene Amplification in Ovarian Cancer
Authors: Joon T. Park, Mei Li, Kentaro Nakayama, Tsui-Lien Mao, Ben Davidson, Zhen Zhang, Robert J. Kurman, Charles G. Eberhart, Ie-Ming Shih, Tian-Li Wang
Journal: Cancer Research (2006)

Abstract Gene amplification is one of the common mechanisms that activate oncogenes. In this study, we used single nucleotide polymorphism array to analyze genome-wide DNA copy number alterations in 31 high-grade ovarian serous carcinomas, the most lethal gynecologic neoplastic disease in women. We identified an amplicon at 19p13.12 in 6 of 31 (19.5%) ovarian high-grade serous carcinomas. This amplification was validated by digital karyotyping, quantitative real-time PCR, and dual-color fluorescence in situ hybridization (FISH) analysis. Comprehensive mRNA expression analysis of all 34 genes within the minimal amplicon identified Notch3 as the gene that showed most significant overexpression in amplified tumors compared with nonamplified tumors. Furthermore, Notch3 DNA copy number is positively correlated with Notch3 protein expression based on parallel immunohistochemistry and FISH studies in 111 high-grade tumors. Inactivation of Notch3 by both γ-secretase inhibitor and Notch3-specific small interfering RNA suppressed cell proliferation and induced apoptosis in the cell lines that overexpressed Notch3 but not in those with minimal amount of Notch3 expression. These results indicate that Notch3 is required for proliferation and survival of Notch3-amplified tumors and inactivation of Notch3 can be a potential therapeutic approach for ovarian carcinomas. (Cancer Res 2006; 66(12): 6312-8)
Pharmacological and genomic profiling identifies NF-κB–targeted treatment strategies for mantle cell lymphoma
Authors: Rami Rahal, Mareike Frick, Rodrigo Romero, Joshua M Korn, Robert Kridel, Fong Chun Chan, Barbara Meissner, Hyo-eun Bhang, Dave Ruddy, Audrey Kauffmann, Ali Farsidjani, Adnan Derti, Daniel Rakiec, Tara Naylor, Estelle Pfister, Steve Kovats, Sunkyu Kim, Kerstin Dietze, Bernd Dörken, Christian Steidl, Alexandar Tzankov, Michael Hummel, John Monahan, Michael P Morrissey, Christine Fritsch, William R Sellers, Vesselina G Cooke, Randy D Gascoyne, Georg Lenz, Frank Stegmeier
Journal: Nature Medicine (2013)
Salmonellosis-Induced Hemorrhage and Ulcerations of the Colon
Authors: G. Cariani, A. Vandelli
Journal: Endoscopy (1993)

See also: Guaiac-Positive Stools and Ulceration of the Colon Associated with SalmonellosisEndoscopy 1991; 23(05): 306-307DOI: 10.1055/s-2007-1010699
Modulation of NKG2D ligand expression and metastasis in tumors by spironolactone via RXRγ activation
Authors: Wai-Hang Leung, Queenie P. Vong, Wenwei Lin, Laura Janke, Taosheng Chen, Wing Leung
Journal: The Journal of Experimental Medicine (2013)

Tumor metastasis and lack of NKG2D ligand (NKG2DL) expression are associated with poor prognosis in patients with colon cancer. Here, we found that spironolactone (SPIR), an FDA-approved diuretic drug with a long-term safety profile, can up-regulate NKG2DL expression in multiple colon cancer cell lines by activating the ATM–Chk2-mediated checkpoint pathway, which in turn enhances tumor elimination by natural killer cells. SPIR can also up-regulate the expression of metastasis-suppressor genes TIMP2 and TIMP3, thereby reducing tumor cell invasiveness. Although SPIR is an aldosterone antagonist, its antitumor effects are independent of the mineralocorticoid receptor pathway. By screening the human nuclear hormone receptor siRNA library, we identified retinoid X receptor γ (RXRγ) instead as being indispensable for the antitumor functions of SPIR. Collectively, our results strongly support the use of SPIR or other RXRγ agonists with minimal side effects for colon cancer prevention and therapy.
Cerebellar Degeneration with Hodgkin's Disease
Authors: G. Valtysson, P. Fisher-Beckfield, P. P. Carbone
Journal: CA A Cancer Journal for Clinicians (1979)

CA: A Cancer Journal for Clinicians publishes information about the prevention, early detection, and treatment of cancer, as well as nutrition, palliative care, survivorship, and additional topics of interest related to cancer care.
Factors Favoring Acute Myocardial Infarction
Authors: David R. Gunraj
Journal: JAMA (1975)

<h3>To the Editor.—</h3> The editorial, "Shrinking the Myocardial Infarct," (230:1310, 1974) draws attention to possible factors that may produce the opposite effect of extending rather than shrinking an infarct and to the usefulness of this knowledge in the prognosis of acute myocardial infarction (AMI) and in the saving of life. We<sup>1</sup>have reported (1) the secondary extension of an infarct in a small group of patients out of a larger number receiving treatment for AMI and (2) the occurrence of AMI in cases that were initially diagnosed as intermediate coronary syndrome and for which treatment had been given. These effects have been noted by others.<sup>2-3</sup>We wish to stress (1) that in both these groups, the second episode (AMI) occurred during active management of the initial event and (2) that in both types a distinct interval existed between the two episodes. Such behavior can be inferred as good
Tracheal gas insufflation: a useful adjunct to ventilation?
Authors: J J Marini
Journal: Thorax (1994)

Tracheal gas insufflation: a useful adjunct to ventilation?How best to coordinate catheter injection with the cycling pattern of the ventilator has not yet been clearly dead space in two patients with obstructive lung disease.'3735 defined.From recent animal experiments it appears that on July 22,
Patients Who Read Their Hospital Charts
Authors: John H. Altman, Peter Reich, Martin J. Kelly, Malcolm P. Rogers
Journal: New England Journal of Medicine (1980)

One controversial aspect of the current emphasis on patients' rights involves the issue of access to one's own medical records. The right to obtain one's own record in federal institutions has been established by law.1 Several states have laws similar to the federal one, and in Massachusetts the Board of Registration in Medicine has even passed a regulation requiring physicians to make office notes available on demand.2 Despite legal trends, controversy still exists about the effect of record reading on clinical care. Some suggest that the routine issuance of records to patients will foster more mutually respectful doctor–patient relations and . . .
Gold excretion in rheumatoid arthritis.
Authors: R A Jones, M U Ahmed, B W Chan
Journal: BMJ (1971)

gastroenteritis and other toxic conditions in infants there was extreme hyperuricaemia-20 mg/100 ml was often recorded.With such levels precipitation of urate in the kid- ney had to be considered.To investigate this possibility experimen- tal production of the syndrome was, effected in rats by blocking the uricase activity with oxonic acid.3By application of sublethal tourniquet shock in these animals we regularly found hyperuricaemia and massive uric acid precipitation in the renal tubules.4It is possible that "shock" kidney is provoked by this mechanism, and the par- ticular purine metabolism of man may also be the explanation of his special proneness to kidney damage in shock.-Weare, etc.,
Dermatoses in lobster fishermen.
Authors: W. E. Beer, W. E. Jones
Journal: BMJ (1969)

Or is it simply that any young man engaged in the climb to consultant ranks simply cannot put a foot out of line for fear of being lost for ever overboard ?If this is true, and I regret to say I think it is, then is it not high time that the medical profession, and specially the colleges, gave a positive lead in demanding, as is demanded in many other countries, that candidates for " the top " should spend some time working abroad.Failing this lead, very soon we will have no one at home with any experience of work abroad other than those in the specialist tropical and military institutions, and in this day and age of rapid travel worldwide medi- cine is brought to the doorstep of every doctor in ever larger quantities.-Iam, etc.,
General Anaesthetics in General Practice
Authors: R. G. Warangham, A. M. A. Clark
Journal: BMJ (1964)

MEDICALcertificate on this evidence alone, but this sign of itself indicates a considerable degree of incoordination.One cannot help prejudging the issue as the question invariably arises, " Is this man likely to be found guilty on this evidence ?" The very posing of this question inevitably results in the issue of many more negative certificates than would otherwise be the case.The time has surely come when we must do away with the clinical examination of the accused and substitute a bloodor urinealcohol level above which it would be an offence to be in charge of a motor vehicle.-I am, etc., Swansea, Glam.
The 1990 Florida Dental Investigation: Theory and Fact
Authors: David Brown
Journal: Annals of Internal Medicine (1996)

Controversy remains about the Centers for Disease Control and Prevention's (CDC) conclusion that a dentist in Florida transmitted human immunodeficiency virus to six of his patients in the late 1980s.The most vocal doubt has come from journalists affiliated with the television program 60 Minutes. Although unanswered questions about the case remain, the evidence continues to overwhelmingly support the CDC's theory. The criticism of the CDC investigation consists largely of assertions that contrary evidence theoretically might exist.
Absorption of Vitamin B12 in Pernicious Anaemia: I. Oral Administration Without a Source of Intrinsic Factor
Authors: C. C. Ungley
Journal: BMJ (1950)

Dynamic mechanical allodynia is a widespread and intractable symptom of neuropathic pain for which there is a lack of effective therapy. We recently provided a novel perspective on the mechanisms of this symptom by showing that a simple switch in trigeminal glycine synaptic inhibition can turn touch into pain by unmasking innocuous input to superficial dorsal horn nociceptive specific neurons through a local excitatory, NMDA-dependent neural circuit involving neurons expressing the gamma isoform of protein kinase C. Here, we further investigated the clinical relevance and processing of glycine disinhibition. First, we showed that glycine disinhibition with strychnine selectively induced dynamic but not static mechanical allodynia. The induced allodynia was resistant to morphine. Second, morphine did not prevent the activation of the neural circuit underlying allodynia as shown by study of Fos expression and extracellular-signal regulated kinase phosphorylation in dorsal horn neurons. Third, in contrast to intradermal capsaicin injections, light, dynamic mechanical stimuli applied under disinhibition did not produce neurokinin 1 (NK1) receptor internalization in dorsal horn neurons. Finally, light, dynamic mechanical stimuli applied under disinhibition induced Fos expression only in neurons that did not express NK1 receptor. To summarize, the selectivity and morphine resistance of the glycine-disinhibition paradigm adequately reflect the clinical characteristics of dynamic mechanical allodynia. The present findings thus reveal the involvement of a selective dorsal horn circuit in dynamic mechanical allodynia, which operates through superficial lamina nociceptive-specific neurons that do not bear NK1 receptor and provide an explanation for the differences in the pharmacological sensitivity of neuropathic pain symptoms.
THE ANTIGENIC POTENCY OF EPIDEMIC INFLUENZA VIRUS FOLLOWING INACTIVATION BY ULTRAVIOLET RADIATION
Authors: Jonas E. Salk, G. I. Lavin, Thomas Francis
Journal: The Journal of Experimental Medicine (1940)

A study of the antigenic potency of influenza virus inactivated by ultraviolet radiation has been made. Virus so inactivated is still capable of functioning as an immunizing agent when given to mice by the intraperitoneal route. In high concentrations inactivated virus appears to be nearly as effective as active virus but when quantitative comparisons of the immunity induced by different dilutions are made, it is seen that a hundredfold loss in immunizing capacity occurs during inactivation. Virus in suspensions prepared from the lungs of infected mice is inactivated more rapidly than virus in tissue culture medium. A standard for the comparison of vaccines of epidemic influenza virus is proposed.
The Influence of Changes in Blood Volume on Angina Pectoris
Authors: JOHN O. PARKER, ROBERT B. CASE, FAREEDUDDIN KHAJA, J. RODNEY LEDWICH, PAUL W. ARMSTRONG
Journal: Circulation (1970)

Angina pectoris was precipitated in 15 patients with coronary artery disease by the technic of right atrial pacing. This was accompanied by hemodynamic evidence of impaired left ventricular function. In eight patients, while pacing was continued, a phlebotomy averaging 276 ml was carried out and in all but one patient angina was relieved and ventricular function returned to normal. Phlebotomy was accompanied by a decline in cardiac index (9.6%) and left ventricular filling pressure, but no change in brachial artery mean pressure, tension-time index, or dp/dt. With reinfusion of blood, angina returned in all but one patient and there was a rise in left ventricular end-diastolic pressure but no change in cardiac index, brachial artery pressure, tension-time index, or dp/dt. In seven patients alterations of blood volume were carried out between three 9-minute periods of atrial pacing and similar observations were obtained. The observations indicate that phlebotomy exerted its beneficial effect through a reduction in left ventricular volume, and it is suggested that this may be the primary mode of action of nitroglycerin.
Abstract LB-162: Translational imaging of tumorigenesis in a <i>TP53</i> porcine cancer model
Authors: Jessica C. Sieren, Xiao-Jun Wang, Bryan Davis, John D. Newell, Emily Hammond, Judy Rohret, Frank Rohret, Jason Struzynski, Adam Goeken, Paul Naumann, Mariah Leidinger, Jussara Hagen, Richard Van Rheeden, Benjamin W. Darbro, Dawn E. Quelle, David K. Meyerholz, Christopher S. Rogers
Journal: Cancer Research (2014)

Abstract Cancer remains the second deadliest disease in the United States, necessitating improvements in tumor diagnosis and treatment. Current model systems of cancer have been informative but also present challenges to translating promising imaging approaches and therapies to the clinic. The lack of a large animal model that accurately mimics human cancer has been a major barrier to the development of effective diagnostic tools and interventions (surgical and therapeutic). This study sought to 1) develop a genetically-modified porcine model of cancer expressing a TP53 mutation commonly found in humans (R175H in people, R167H in pigs), 2) validate the cellular p53 mutation and 3) evaluate tumor development in the animals using medical imaging, histopathology and molecular approaches. TP53R167H/R167H mutant pigs primarily developed lymphomas and osteogenic tumors, mimicking the tumor types observed in mice and humans expressing the orthologous TP53 mutant allele. CT and MRI imaging data effectively detected developing tumors, which were validated by histopathologic evaluation following necropsy. Molecular genetic analyses confirmed mutant p53 expression and characteristic chromosomal instability within the tumors. In conclusion, TP53R167H/R167H pigs provide a novel large animal tumor model that replicates the human condition and is uniquely suited to developing clinically-relevant, non-invasive imaging approaches to facilitate earlier detection, diagnosis and treatment of human cancers. Citation Format: Jessica C. Sieren, Xiao-Jun Wang, Bryan Davis, John D. Newell, Emily Hammond, Judy Rohret, Frank Rohret, Jason Struzynski, Adam Goeken, Paul Naumann, Mariah Leidinger, Jussara Hagen, Richard Van Rheeden, Benjamin W. Darbro, Dawn E. Quelle, David K. Meyerholz, Christopher S. Rogers. Translational imaging of tumorigenesis in a TP53 porcine cancer model. [abstract]. In: Proceedings of the 105th Annual Meeting of the American Association for Cancer Research; 2014 Apr 5-9; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2014;74(19 Suppl):Abstract nr LB-162. doi:10.1158/1538-7445.AM2014-LB-162