MULTIPLE TESTS OF HEPATIC FUNCTION IN GASTROENTERIC MALIGNANCY; THE VALUE OF BROMSULPHALEIN, HIPPURIC ACID AND THE VAN DEN BERGH REACTION IN DETECTING HEPATIC METASTASIS, WITH AN EVALUATION OF NORMALITY OF THE HIPPURIC ACID TEST
Authors: Moses Paulson, Carl I. Wyler
Journal: Annals of Internal Medicine (1942)

Article1 May 1942MULTIPLE TESTS OF HEPATIC FUNCTION IN GASTROENTERIC MALIGNANCY; THE VALUE OF BROMSULPHALEIN, HIPPURIC ACID AND THE VAN DEN BERGH REACTION IN DETECTING HEPATIC METASTASIS, WITH AN EVALUATION OF NORMALITY OF THE HIPPURIC ACID TESTMOSES PAULSON, M.D., F.A.C.P., CARL I. WYLER, M.D.MOSES PAULSON, M.D., F.A.C.P.Search for more papers by this author, CARL I. WYLER, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-16-5-872 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptFrom time to time throughout the past years communications have appeared which have indicated that the prediction of the existence of hepatic metastasis was a possibility. In 1925 Rowntree and his associates1using phenol tetrachlorphthalein concluded that "in the absence of clinical evidence of hepatic involvement the phenoltetrachlorphthalein test may furnish the only evidence of the existence of metastatic nodules in the liver." Positive tests were not obtained in all cases of metastatic involvement. Bargen and Rankin,2in 1930, felt that their results, using bromsulphalein and the van den Bergh test in carcinoma of the large bowel, were statistically indicative...Bibliography1. GREENEMCVICKERWALTERSROWNTREE CHCSWLG: Diseases of the liver. IV. Functional tests in cases of carcinoma of the liver and biliary tract, Arch. Int. Med., 1925, xxxvi, 542-560. CrossrefGoogle Scholar2. BARGENRANKIN JAFW: Tests of hepatic function in carcinoma; their value in cases of neoplasm of colon with and without metastasis to liver, Ann. Surg., 1930, xci, 225-232. CrossrefGoogle Scholar3. 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BESTTAYLOR CHNB: The physiological basis of medical practice, 2nd edition, 1939, Williams and Wilkins Co., Baltimore. Google Scholar15. HAINESMAGATHPOWER SFTBMH: Hippuric acid test in hyperthyroidism, Proc. Staff Meet. Mayo Clin., 1939, xiv, 495-496. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: *Received for publication July 13, 1941.From the Gastrointestinal Section and Laboratories of the Medical Clinic of the Johns Hopkins Hospital and University, Baltimore. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byExcretory function of the liver in gastric diseasesThe Clinical Chemistry of Bromsulfophthalein and Other Cholephilic DyesSerum enzymes in disease.XIV. Abnormality of levels of transaminases and glycolytic and oxidative enzymes and of liver functions as related to the extent of metastatic carcinoma of the liverA Method for the Colorimetric Determination of β-Glucuronidase in Urine, Serum, Tissue; Assay of Enzymatic Activity in Health and DiseaseThe hippuric acid index: Application of the hippuric acid test as an index of human free anxietySul Comportamento Di Alcune Prove Di Funzionalita’ Epatica in Presenza Di Carcinoma Metastatico Del FegatoThe value of liver-function tests in the diagnosis of intrahepatic metastases in the nonicteric cancer patientHIPPURIC-ACID SYNTHESIS TEST OF - LIVER FUNCTIONLiver function tests in the aged (The serum cholesterol partition, bromsulphalein, cephalin-flocculation and oral and intravenous hippuric acid tests) 1 May 1942Volume 16, Issue 5Page: 872-878KeywordsGastroenterology and hepatologyHospitalsLiverSurgeons ePublished: 1 December 2008 Issue Published: 1 May 1942 PDF downloadLoading ...