Weight Loss and Serum Lipid Changes in Obese Subjects Given Low Calorie Diets of Varied Cholesterol Content
Authors: WILLIAM B. GALBRAITH
Journal: Annals of Internal Medicine (1966)

Article1 February 1966Weight Loss and Serum Lipid Changes in Obese Subjects Given Low Calorie Diets of Varied Cholesterol ContentWILLIAM B. GALBRAITH, M.D., WILLIAM E. CONNOR, M.D., F.A.C.P., DANIEL B. STONE, M.B., F.A.C.P.WILLIAM B. GALBRAITH, M.D., WILLIAM E. CONNOR, M.D., F.A.C.P., DANIEL B. STONE, M.B., F.A.C.P.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-64-2-268 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptDespite considerable investigation, the effects of weight reduction upon the serum lipids remain controversial. Earlier studies have emphasized that loss of body weight may cause a change in the serum cholesterol concentration, but a review of the literature dealing with the subject provides no clear conclusion about this relationship. Some investigators have reported that weight loss was accompanied by a decline in serum lipid levels (1-5) whereas others observed no changes (6-9) or an actual increase (10).The experiments to be reported now had two objectives. The first objective was to determine the influence of weight loss upon serum cholesterol...References1. KEYSBROZEKHENSCHELMICKELSENTAYLOR AJAOH: The Biology of Human Starvation, Vol. 1. The University of Minnesota Press, Minneapolis, 1950, p. 498. CrossrefGoogle Scholar2. WALKERWEIR WJJA: Plasma cholesterol levels during rapid weight reduction. Circulation 3: 864, 1951. CrossrefMedlineGoogle Scholar3. WALKERLOWRYLOVEMANNLEVINESTARE WJEYDEGVSAFJ: Effect of weight reduction and caloric balance on serum lipoprotein and cholesterol levels. Amer. J. Med. 14: 654, 1953. CrossrefMedlineGoogle Scholar4. JOLLIFFERINZLERARCHER NSHM: Prudent reducing diet: effect on serum cholesterol. Study of 111 obese men 50-59 years old. Arch. Intern. Med. (Chicago) 109: 566, 1962. 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CONNORHODGESBLEILER WERERE: Effect of dietary cholesterol upon serum lipids in man. J. Lab. Clin. Med. 57: 331, 1961. MedlineGoogle Scholar12. CONNORHODGESBLEILER WERERE: The serum lipids in men receiving high cholesterol and cholesterol-free diets. J. Clin. Invest. 40: 894, 1961. CrossrefMedlineGoogle Scholar13. CONNORSTONEHODGES WEDBRE: The interrelated effects of dietary cholesterol and fat upon human serum lipid levels. J. Clin. Invest. 43: 1691, 1964. CrossrefMedlineGoogle Scholar14. : Statistical Bulletin. 40: 1, 1959. Google Scholar15. ABELLLEVYBRODIEKENDALL LLBBBBFE: A simplified method for the estimation of total cholesterol in serum and demonstration of its specificity. J. Biol. Chem. 192: 357, 1952. CrossrefGoogle Scholar16. VAN HANDELZILVERSMIT EDB: Micromethod for the direct determination of serum triglycerides. J. Lab. Clin. Med. 50: 152, 1957. MedlineGoogle Scholar17. GORDONGOLDBERGCHOSEY ESMGJ: A new concept in the treatment of obesity. JAMA 186: 50, 1963. CrossrefMedlineGoogle Scholar18. GAMBLEROSSTISDALL JLGSFF: The metabolism of fixed base during fasting. J. Biol. Chem. 57: 633, 1923. CrossrefGoogle Scholar19. BLOOMAZAR WLGJ: similarities of carbohydrate deficiency and fasting. I. Weight loss, electrolyte excretion and fatigue. Arch. Intern. Med. (Chicago) 112: 333, 1963. CrossrefMedlineGoogle Scholar20. TOMPKINSCHAIKOFF GMIL: Cholesterol synthesis by the liver: I. Influence of fasting and diet. J. Biol. Chem. 196: 569, 1952. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Iowa City, IowaFrom the Department of Internal Medicine, University of Iowa College of Medicine, Iowa City, Iowa.This study was supported by research grants H7239 and AM 06090, U. S. Public Health Service, research grant MO1-FR-59, National Institutes of Health General Clinical Research Centers Branch, Bethesda, Md., and by the Iowa Heart Association.Dr. Connor was the recipient of U. S. Public Health Service Research Career Program Award HE-K3-18406 from the National Heart Institute, National Institutes of Health, Bethesda, Md.This study was presented at the Annual Meeting of the Midwest Section of the American Federation for Clinical Research, November 5, 1965, Chicago, Ill.Requests for reprints should be addressed to William E. Connor, M.D., Department of Internal Medicine, University of Iowa College of Medicine, Iowa City, Iowa 52240. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByPPARγ activation redirects macrophage cholesterol from fecal excretion to adipose tissue uptake in mice via SR-BIThe future of obesity reduction: beyond weight lossDietary cholesterol and coronary heart diseaseHypercholesterolaemia of prolonged fasting and cholesterol lowering of re-feeding in lean human subjectsReport of the Expert Panel on Population Strategies for Blood Cholesterol Reduction. A statement from the National Cholesterol Education Program, National Heart, Lung, and Blood Institute, National Institutes of Health.The cholesterol facts. A summary of the evidence relating dietary fats, serum cholesterol, and coronary heart disease. A joint statement by the American Heart Association and the National Heart, Lung, and Blood Institute. The Task Force on Cholesterol Issues, American Heart Association.Adipose tissue and cholesterol metabolism.Serum Lipid Changes after Gastroplasty for Morbid ObesitySerum triglycerides, cholesterol, low density lipoprotein-apo B and high density lipoprotein cholesterol subfractions after moderate body weight lossInfluence of weight reduction on plasma lipoproteins in obese patients.Dietary determinants of plasma cholesterol change in the recruitment phase of the Lipid Research Clinics Coronary Primary Prevention Trial.Behavioral treatment of hyperlipidemia: Techniques, results, and future directionsThe Dietary Treatment of Hyperlipidemia: Rationale, Technique and EfficacyLipoproteins in Nutrition and TransportEffects of caloric restriction on lipid metabolism in man changes of tissue lipoprotein lipase activities and of serum lipoproteinsType III hyperlipoproteinemiaReduction of atherosclerotic disease in genetically obese rats by low calorie dietCholesterol metabolism in Papua New GuineansThe Effects of Nutrition on Lipid MetabolismFettsucht und Diabetes mellitusObesity: Changes in lipid metabolism and the role of insulinLiteraturThe Pathogenesis of HypercholesterolemiaWALTER M. BORTZ, M.D.DIETARY FAT AND CORONARY HEART DISEASE: A REVIEW * : III. A COMMUNITY PROGRAMMEWeight regain after low calorie diet: Long term pattern of blood sugar, serum lipids, ketone bodies and serum insulin levelsEffects of isocaloric exchange of dietary sucrose and starch on fasting serum lipids, postprandial insulin secretion and alimentary lipaemia in human subjectsFrequency of Feeding, Weight Reduction, and Nutrient Utilization1Gewichtsreduktion bei Adipositas durch Di�t, Medikamente und operative VerfahrenEffect of Diet and/or Exercise on Obese College Women1Effect of prolonged starvation on blood lipid levels of obese subjectsEvaluation of the effects of egg yolk lipids upon plasma lipids in human subjectsMeasures to Reduce the Serum Lipid Levels in Coronary Heart DiseaseEinflu� der Gewichtsreduktion auf Metabolite des Kohlenhydrat- und Fettstoffwechsels und auf das Verhalten des Seruminsulins bei AdipositasFecal steroid excretion during weight reduction in obese patients with hyperlipidemiaThe influence of dietary regimens on serum fat in atherosclerotic subjectsBlood lipid and glucose levels during a ten-day period of low-calorie intake and exercise in manREFERENCES 1 February 1966Volume 64, Issue 2Page: 268-275KeywordsCholesterolHealth services researchHeartIngestionLipidsLongitudinal studiesOverweightProteinsResearch grantsWeight loss Issue Published: 1 February 1966 PDF DownloadLoading ...