Purpuric Skin Manifestations Following the Use of Merbaphen
Authors: Albert M. Snell, Leonard G. Rowntree
Journal: Annals of Internal Medicine (1928)

Article1 July 1928Purpuric Skin Manifestations Following the Use of MerbaphenALBERT M. SNELL, M.D., LEONARD G. ROWNTREE, M.D.ALBERT M. SNELL, M.D.Search for more papers by this author, LEONARD G. ROWNTREE, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-2-1-97 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptSince the introduction of merbaphen as an antisyphilitic agent and a diuretic much attention has been directed to its toxic effects. These have been, in general, indicative of mercurial poisoning, and include stomatitis, diarrhea, and renal irritation; minor toxic symptoms, such as slight fever, chills, malaise, and headaches, are common, but more severe reactions are relatively rare. Marvin has described something resembling a state of shock with chills, sweating, cyanosis, collapse, and occasionally urinary suppression following its use. Deaths have also been attributed to the drug (Redlich) not only when used as a diuretic, but as a remedy for syphilis....Bibliography(1) JACOBJ J: Untersuchungen zur Pharmakologie des Veronals. III Die Eigenart der Veronal wirkung eine Folge seiner spezifisch peripheren La̋hmungswirkung auf die Gefa̋ssivano. Arch. f. exper. Path. u. Pharmakol. 1911, lxv-lxvi, 296-312. CrossrefGoogle Scholar(2) KNOWLES FC: Purpura caused by the ingestion of the iodides. Jour. Am. Med. Assn., 1910, lv, 100-106. CrossrefGoogle Scholar(3) KOLLERT : Quoted by Schur. Google Scholar(4) KULCKE E: Novasurol als Diureticum. Klin. Wchnschr., 1922, i, 622-625. CrossrefGoogle Scholar(5) LEVY-LENZ : Erfahrungen mit Novasurol. Therap. Halbmonatsh., 1920, xxxiv, 388. Google Scholar(6) MARCUS S: An experience with novasurol. Can. Med. Assn. Jour., 1926, xvi, 690-691. Google Scholar(7) MARVIN HM: Merbaphen (novasural) as a diuretic in congestive heart failure. Jour. Am. Med. Assn., 1926, lxxxvii, 1016-1020. CrossrefGoogle Scholar(8) MÜHLING A: Studie űber die diuretische Wirkungsweise von Quecksilber, Ausgefűhrt mit dem organischen Quecksilber pra̋parat Novasurol. Műnchen. med. Wchnchr., 1921, ii, 1447-1449. Google Scholar(9) PEZOLD V: Neosalvarsan in Mischspritze mit Novasurol. Műnchen. med. Wchsnschr., 1923, ii, 1154. Google Scholar(10) PUSEY WA: The principles and practice of dermatology. Ed. 4, New York, D. Appleton & Co., 1924, 1222 pp. Google Scholar(11) REDLICH F: Letale Quecksilberintoxikation nach einmaliger Novasurolinjektion. Wien. klin. Wchnschr., 1925, xxxviii, 359-360. Google Scholar(12) SAXL P: Letale Quecksilberintoxikation nach einmaliger Novasurolinjektion. Wien. klin. Wchnschr., 1925, xxxviii, 437. Google Scholar(13) SCHUR H: Klinisch-experimentelle Studien űber Novasuroldiurese und Nierenfunktion. Wien. Arch. f. inn. Med., 1923, vi, 175-214. Google Scholar(14) SOLLMAN TH: A manual of pharmacology. Ed. 3, Philadelphia, W. B. Saunders Co., 1926, 757-759. Google Scholar(15) STELWAGON HW: A treatise on disease of the skin. Ed. 8, Philadelphia, W. B. Saunders Co., 1926, 1309 p. Google Scholar(16) TOMASCZEWSKI E: Über Quecksilberexantheme und Quecksilberidosynkrasie. Ztschr. f. klin. Med., 1904, li, 439-474. Google Scholar(17) VOIGT : Erfahrungen mit Novasurol. Therap. Halbmonatsch., 1920, xxxix, 263. Google Scholar(18) ZEILER K: Novasurol, ein neues Quecksilbersalz sur Syphilisbehandlung, mit Bemerkungen űber die Grundsatze der Quecksilberbehandlung. Műnchen. Med. Wchnschr., 1917, ii, 1257-1259. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Division of Medicine The Mayo Clinic The Mayo Foundation Rochester, Minnesota*Submitted for publication April 24, 1928. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byQuecksilberhaltige DiureticaSYSTEMIC REACTIONS TO A MERCURIAL DIURETIC (MERCAPTOMERIN)TOXIC REACTION TO MERCAPTOMERIN (THIOMERIN): CASE REPORT*ROBERT LLOYD SEGAL, M.D.Dangers of Dehydration Treatment in Heart Disease 1 July 1928Volume 2, Issue 1Page: 97-103KeywordsDiarrheaDiureticsDrugsFeversShockSyphilis ePublished: 1 December 2008 Issue Published: 1 July 1928 PDF downloadLoading ...