tbuckley/cabot-search huggingface dataset:
Abstract 17257: The Association Between Diet Quality After Diabetes Diagnosis and Major Cardiovascular Events in Women With Type 2 Diabetes Mellitus
Authors: Hyun J Shin, Peter A McCullough, Shanshan Li, Eunyoung Cho, Eric Rimm, Bernard Rosner, JoAnn E Manson, Frank B Hu
Journal: Circulation (2014)

Introduction: The role of dietary choices in the prevention of cardiovascular hard-outcome among type 2 diabetes patients has not been studied well. We examined whether there is an association between dietary quality after diagnosis of type 2 diabetes and major cardiovascular events among women using long-term prospective cohort study. Hypothesis: Healthy dietary pattern after type 2 diabetes diagnosis is associated with decreased risk for major cardiovascular events among women. Methods: The women with type 2 diabetes (n=6,895, mean age 64 years old) from the Nurses’ Health Study with no baseline cancer or cardiovascular disease were selected. Cox proportional hazard model was used to assess the multivariate association between the alternate Healthy Eating Index (aHEI) and the first episode of major cardiovascular events (coronary heart disease (CHD) or stroke). Results: During 26 years of follow-up (75, 276 person-years), a total of the 705 major cardiovascular events (432 cases of CHD, 314 cases of stroke, 41 cases of both CHD and stroke) were documented. The age-adjusted relative risks of major cardiovascular events across quintiles of aHEI score (Q1, Q2, Q3, Q4, Q5) were 1, 0.99 (95% CI, 0.80 to 1.22), 0.84 (CI, 0.67 to 1.05), 0.57 (CI, 0.44 to 0.72), and 0.66 (CI, 0.52 to 0.84) (P &lt; 0.0001 for trend). These figures did not change materially after adjustment for body mass index, physical activity, smoking and other cardiovascular risk factors (1, 1.00, 0.91, 0.63, and 0.80, respectively; P = 0.008 for trend). The multivariate relative risks for stroke and CHD across quintiles of aHEI score were 1, 0.72, 0.80, 0.46, and 0.72 (P = 0.028 for trend) and 1, 1.21, 0.96, 0.72, and 0.73 (p=0.014 for trend), respectively. Conclusions: Healthier dietary habits after the diagnosis of diabetes are associated with a reduced risk of cardiovascular events including stroke and coronary heart disease.
247. Expressing Full-Length Dystrophin in 50% Cardiomyocytes Corrects Cardiomyopathy in the Mdx Mouse Model for Duchenne Muscular Dystrophy
Authors: Zhilong Jiang, Paula R. Clemens
Journal: Molecular Therapy (2004)

Muscle wasting, a syndrome characterized by the disproportional loss of skeletal muscle, is a frequent complication in patients with cancer or other chronic diseases. Recent studies in vitro and in vivo have demonstrated that tumor cells produce and secrete cytokines such as TNF- α that are responsible for inhibition of differentiation of myoblast cells into multinucleated myotubes and thereby may prevent muscle repair in cancer patients. Activation of NF-κB triggered by TNF-α interaction with its receptor on muscle cells, is considered a major pathway through which cytokines lead to muscle wasting in cancer patients. Gene therapy offers a potential solution by modulating downstream events within muscle cells. In vitro models of muscle wasting can provide an important resource to understand which pathways to modulate and to test potential therapies. In our In vitro studies, we found that application of TNF-α results in apoptosis of primary C57 mouse myoblast cells at 3 days after treatment. IFN-γ, IL-1β and IL-6 do not lead to apoptosis of myoblast cells, but result in inhibition of myoblast differentiation at 20 ng/ml. In addition, the conditioned media from human prostate cancer cell lines (PC-3 and DU145P) and a human melanoma cell line (Mel) significantly inhibit the differentiation of myoblast cells. NF-κB activity was activated in treated myoblast cells compared to untreated or 293 cell culture supernatant-treated myoblast cells. However we found that myoblasts stably transfected with IKBSR, a mutant IKBα, or cellular FLICE/Caspase-8-inhibitory protein, cFLIP, inhibited NF-κB activation after treatment of myoblast cells with cytokines (TNF-α, IFN-γ, IL-1β or IL-6) or tumor cell conditioned media (PC-3, DU145P or Mel). Inhibition of NF-κB activation was associated with amelioration of the inhibition of muscle cell differentiation. To our knowledge, this is the first report that cFLIP, an important caspase-8-inhibitory protein is capable of inhibiting NF-κB activation and reducing inhibition of myoblast cell differentiation treated with PC-3, DU145P and Mel tumor media. The results encourage us to generate gene transfer virus vectors expressing IKBSR or cFLIP or both, and to determine whether IKBSR or cFLIP or both can ameliorate muscle wasting.
Abstract 2549: Natural Course of Lipid-rich Plaques Assessed with Combination of Intra-vascular Ultrasound and Optical Coherence Tomography
Authors: Shigeho Takarada, Takashi Kubo, Takashi Tanimoto, Hironori Kitabata, Nobuo Nakamura, Kumiko Hirata, Atsushi Tanaka, Masato Mizukoshi, Toshio Imanishi, Takashi Akasaka
Journal: Circulation (2008)

Background Identification of coronary lesions with morphological characteristic of “rupture-prone plaques” is not sufficient. We examined the natural history of non-culprit lipid-rich plaques in patients with acute coronary syndrome (ACS). Methods Fifty patients with ACS who underwent percutaneous coronary intervention (PCI) were enrolled. We retrospectively assessed the extent of residual non-culprit lipid-rich plaques and these fibrous cap thickness (FCT) by use of intra-vascular ultrasound (IVUS) and optical coherence tomography (OCT), respectively, at baseline and after 9-months. Results During 9 months follow-up periods, the change in percent area volume (PAV) was 0.42±0.6% and the change in FCT was 14±12%. Percent change in PAV showed a significant positive correlation with percent LDL-C reduction (R=0.52, P&lt;0.01). In contrast, the change in FCT demonstrated no correlation with LDL-C level, but had a significant positive correlation with percent change in high sensitive CRP (R=0.60, P&lt;0.01). And between PAV and FCT changes, no significant correlation was observed. Furthermore, in a multivariable analysis including age, sex, diabetes mellitus, hypertension, several concomitant drugs, only statin-use was the independent predictor for changing well-stabilized plaques, which obtained both PAV reduction and FCT increase. Conclusion The change in PAV and in FCT of coronary plaques during 9-months was related to the two different independent factor (reduction rate of LDL-C and high sensitive CRP, respectively). Furthermore, lipid lowering therapy by use of statin has a potential to stabilize them by both plaque reduction and fibrous cap thickening.
DRUG REACTIONS XIV
Authors: John Almeyda, ÖSten Hägermark, Göran Wennersten
Journal: British Journal of Dermatology (2006)

Journal Article DRUG REACTIONS XIV: Cutaneous Side Effects of Phenothiazines Get access John Almeyda, John Almeyda London Hospital Whitechapel, E.I Search for other works by this author on: Oxford Academic Google Scholar ÖSten Hägermark, ÖSten Hägermark Karolinska sjukhuset Stockholm Search for other works by this author on: Oxford Academic Google Scholar Göran Wennersten Göran Wennersten Karolinska sjukhuset Stockholm Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 84, Issue 6, 1 June 1971, Pages 605–607, https://doi.org/10.1111/j.1365-2133.1971.tb02557.x Published: 01 June 1971
Analysis of &lt;italic&gt;W&lt;/italic&gt;-Series Pleiotropism in the Mouse: Effect of &lt;italic&gt;W&lt;sup&gt;υ&lt;/sup&gt;W&lt;sup&gt;υ&lt;/sup&gt;&lt;/italic&gt; Substitution on Definitive Germ Cells and on Ovarian Tumorigenesis&lt;xref ref-type="fn" rid="FN1"&gt;2&lt;/xref&gt;
Authors: Elizabeth S. Russell, Elizabeth Fekete
Journal: JNCI Journal of the National Cancer Institute (1958)
MORBIDITY AND MORTALITY IN SANTO TOMAS INTERNMENT CAMP
Authors: Emmet F. Pearson
Journal: Annals of Internal Medicine (1946)

Article1 June 1946MORBIDITY AND MORTALITY IN SANTO TOMAS INTERNMENT CAMPEMMET F. PEARSONEMMET F. PEARSONSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-24-6-988 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe internment of Americans and allied national civilians in the Philippine Islands for 37 months by the Japanese in Internment Camp No. 1 at Santo Tomas University, Manila, and two auxiliary camps, No. 2 at Los Banos and No. 3 at Baguio, was an experience unique in American history. A narrative account of the health, morbidity and mortality of the civilian internees is a story which is, on the one hand, a high tribute to the internees themselves and the medical care that they received, and, on the other hand, an indictment of their Japanese captors. These civilian internee camps... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: *Received for publication October 8, 1945. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 June 1946Volume 24, Issue 6Page: 988-1013KeywordsCyclic adenosine monophosphateMorbidityMortality ePublished: 1 December 2008 Issue Published: 1 June 1946 PDF downloadLoading ...
SEDIMENTATION TIME IN ACUTE CARDIAC INFARCTION
Authors: Charles Shookhoff, Albert H. Douglas, Meyer A. Rabinowitz
Journal: Annals of Internal Medicine (1936)

Excerpt In 1931 the authors reported 10 cases of acute cardiac infarction secondary to coronary artery thrombosis in which the red blood cell sedimentation time was studied.1 Burak2 subsequently reported a similar study, but the literature on the subject has, in general, been scant. Singer3 and Wollheim4 have both mentioned the increased rapidity of red cell sedimentation rate as a diagnostic factor in coronary thrombosis. Because the sedimentation time has frequently been of great help to us in the diagnosis and treatment of acute coronary thrombosis, we are reporting an additional series of cases studied during the past three years. METHOD
784. An AdEASY Based Cloning System for Generating Adenoviral Vectors That Express Transgenes Late in the Viral Life Cycle
Authors: Michael Lie-A-Ling, Conny Bakker, John G. Wesseling, Piter J. Bosma
Journal: Molecular Therapy (2004)

Research in adenoviral cancer gene therapy is mostly focused on targeting of replicating vectors. However for clinical efficacy oncolytic activity of these vectors is also an important issue. Early clinical trials in which conditionally replicating adenoviral vectors were used showed, if any, a limited anti-tumor effect.
Abstract 9348: ROCK2 in Vascular Smooth Muscle Cells Plays a Crucial Role for Hypoxia-Induced Pulmonary Hypertension in Mice
Authors: Toru Shimizu, Kimio Satoh, Shin-ichi Tanaka, Yoshihiro Fukumoto, Hiroaki Shimokawa
Journal: Circulation (2011)

Background: Pulmonary hypertension (PH) still remains a fatal disease characterized by progressive increase in pulmonary vascular resistance. We have previously demonstrated that the Rho-kinase (ROCK) pathway in vascular smooth muscle cells (VSMC) plays an important role in the pathogenesis of cardiovascular diseases by enhancing their migration and proliferation. Rho-kinase has 2 isoforms, ROCK1 and ROCK2, with different functions; ROCK1 for circulating inflammatory cells and ROCK2 for the vasculature. In this study, we thus examined whether ROCK2 in VSMC is involved in the pathogenesis of PH. Methods and Results: We developed VSMC-specific ROCK2-deficient (ROCK2 +/- ) and VSMC-specific ROCK2-overexpressing (ROCK2-Tg) mice. Both genotypes showed normal growth under physiological conditions. Chronic hypoxia (10% O 2 for 4 weeks) significantly increased ROCK2 expression and ROCK activity in lung tissues from littermates (P&lt;0.05, n=4 each). The extent of the hypoxia-induced PH, as evaluated by the extent of pulmonary vascular remodeling, right ventricular (RV) systolic pressure and RV hypertrophy, was significantly reduced in ROCK2 +/- mice and was significantly enhanced in ROCK2-Tg mice compared with the littermates (all P&lt;0.05). Immunostaining showed that the number of CD45 + inflammatory cells in the lung was significantly reduced in the ROCK2 +/- mice and was increased in the ROCK2-Tg mice compared with the littermates, suggesting the role of vascular ROCK2 in inflammatory cell recruitment. In addition, VSMC proliferation (Ki67 + cells) significantly correlated with the ROCK2 expression after chronic hypoxia, suggesting the role of ROCK2 in VSMC proliferation. In cultured mouse aortic VSMC, ROCK2 expression was decreased in ROCK2 +/- VSMC (-21%) and was increased in ROCK2-Tg VSMC (+100%) compared with littermate VSMC. Hypoxia (1% O 2 for 24 hours) significantly increased ROCK activity in littermate VSMC (P&lt;0.05, n=5 each). Scratch assay showed that migration activity was significantly reduced in the ROCK2 +/- VSMC and was increased in the ROCK2-Tg VSMC compared with littermate VSMC (P&lt;0.01). Conclusions: ROCK2 in VSMC plays a crucial role in the pathogenesis of hypoxia-induced PH through enhanced VSMC migration and proliferation.
Abstract MP54: Dietary Protein Lowers Obesity Risk in Middle-Aged Framingham Offspring Study Adults
Authors: Justin Rene Buendia, Syed Ridda Hasnain, M. Loring Bradlee, Martha R Singer, Ralph B D'Agostino, Lynn L Moore
Journal: Circulation (2015)

Aging triggers increases in fat mass and changes in body composition. Since dietary protein may impact the balance of lean/fat mass, it has been suggested that current Dietary Guidelines for protein may be inadequate for older adults. Using data from the Framingham Offspring Study, we examined the role of dietary protein on body mass index (BMI), waist size, and risks of obesity and excess central adiposity in middle-aged adults. Dietary data were derived from 3-day records collected in exams 3 and 5 in 1490 subjects, ages 30-54 years who were free of diabetes, CVD and cancer. Protein intakes (total, animal, and plant) were expressed as weight-adjusted residuals to minimize potential confounding by body size. BMI and waist circumference were measured at each exam. Analysis of covariance (ANCOVA) was used to estimate mean follow-up BMI and waist size while controlling for the following potential confounders: age, sex, education, height, activity, smoking, total energy intake, % energy from fat, and baselin...
Abstract 17092: Intravascular Integrated OCT/NIRF Molecular Imaging with a Novel Mannose Receptor Targeting NIRF Probe to Identify Macrophage-rich High-Risk Plaques
Authors: Jae Joong Lee, Kyeongsoon Park, Han Saem Cho, Min Woo Lee, Jun Woo Song, Dong Joo Oh, Wang-Yuhl Oh, Hongki Yoo, Jin Won Kim
Journal: Circulation (2014)

Background: Macrophage-rich active inflammatory plaques are at high-risk associated with acute coronary events. In current study, we newly developed a near-infrared fluorescence (NIRF) probe targeting mannose receptors which are expressed on plaque macrophages, and combined it with a fully integrated OCT (optical coherence tomography)/NIRF structural-molecular imaging to identify macrophage-rich high-risk plaques in coronary-sized vessels. Methods and Results: A novel mannose receptor targeting probe was synthesized by chemically conjugating thiolated glycol chitosan with mannose-PEG-maleimide, and then further labeled it with NIRF emitting cyanine7 (ex/em 750 and 773nm). I.V. injection of the NIRF-nanoprobe at a dose of 10 mg/kg into balloon injured rabbits fed with high cholesterol diet was done 48 hours prior to imaging. In vivo OCT/NIRF imaging was performed in the infrarenal aorta and iliac artery at a high pullback speed (20mm/sec) just under contrast flushing, followed by ex vivo fluorescence refle...
Non-invasive ventilation (NIV) in acute respiratory failure in a respiratory intermediate unit care (RICU) – Characterization and predictors of failure
Authors: Ana Sofia Oliveira, Sara Salgado, Cecília Nunes, Fernanda Oliveira, Cristina Bárbara
Journal: European Respiratory Journal (2011)

Aims:  The use of NIV has proliferated in the last decades in order to support patients with acute respiratory failure. We aimed to analyze NIV9s success in RICU.   Methods:  A systematic retrospective review was performed of all hospitalized patients for NIV in our RICU, from February 1 to July 31, 2010.   Results:  NIV was performed in 79 patients, 73% were male, with a mean age of 70 years (35-93). Reasons for NIV were acute respiratory failure in 66 patients and continuation of NIV resulting from step-down ICU in 13. Six patients had hypoxemia, 64 hypercapnia and 9 mixed acidosis. Most patients had chronic diseases (cardiac and respiratory), 62% had previous hospital admissions and 27% previous invasive mechanical ventilation. Infectious respiratory exacerbations were the main cause for admission. In 18 patients do not intubate decision was made. Average stay in RICU was 10 days (1-76). The majority of the patients had favorable evolution under NIV (57), however there were 22 NIV failures, with 5 ICU transfers. Concerning the group of NIV failure, they were significantly older (p=0,042), showed more previous hospital admissions (p=0,030), more nosocomial respiratory infections (p=0,000), a lower PaO 2 /FiO 2  (p=0,015), more extensive radiological disease (p=0,017), more neoplasic underling disease (p=0,031), more renal disease (p=0,009) and end-stage palliation (p=0,000).   Conclusion:  NIV is a common and indispensable treatment in a RICU. NIV9s results are in accordance with the severity of underling disease, acute exacerbations and with the use of NIV as ceiling support.
Fibulin-5 deposition in human skin: decrease with ageing and ultraviolet B exposure and increase in solar elastosis
Authors: K. Kadoya, T. Sasaki, G. Kostka, R. Timpl, K. Matsuzaki, N. Kumagai, L.Y. Sakai, T. Nishiyama, S. Amano
Journal: British Journal of Dermatology (2005)

Fibulin-5 was recently found as a secreted extracellular matrix protein that functions as a scaffold for elastic fibres. However, the distribution of fibulin-5 in human skin and its changes during the ageing process are not known.To explore the involvement of fibulin-5 in skin ageing, the age-dependent changes in fibulin-5 localization in human skin were examined compared with those of other elastic fibre components including elastin, fibrillin-1 and fibulin-2. Methods The distribution of elastin, fibrillin-1, fibrillin-2, fibulin-2 and fibulin-5 was investigated by means of immunohistochemistry using their specific antibodies. Skin samples were recovered from 12 healthy subjects undergoing plastic surgery. Ultraviolet (UV) B-irradiated or control nonirradiated buttock skin samples were obtained from two healthy volunteers at 2 days after the irradiation at 2 minimal erythemal doses.In the reticular dermis of young sun-protected skin from the upper arm, fibulin-5 colocalized with the other elastic fibre components, while in the papillary dermis fibulin-5 showed candelabra-like structures perpendicular to the epidermis with an unstained area just beneath the epidermis, which was similar to that of elastin but not fibrillin-1. Fibulin-5 in the reticular dermis decreased and disappeared with age even in sun-protected skin from the thigh, abdomen and upper arm. In sun-exposed skin, fibulin-5 was extremely reduced in the dermis of cheek skin even from a 20-year-old man. UVB irradiation reduced fibulin-5, fibulin-2 and elastin markedly, moderately and weakly, respectively, compared with levels in control nontreated skin. Interestingly, the deposition of fibulin-5 was increased in solar elastosis, like that of other elastic fibre components.These results suggest that fibulin-5 is a good marker of skin ageing and that the earlier loss of fibulin-5 may involve age-dependent changes in other elastic fibre components.
Fertility after treatment for cancer
Authors: J. Radford, S. Shalet, B. Lieberman
Journal: BMJ (1999)

An increasing number of people are being successfully treated for cancer, and for those with an expectation of long-term survival the late effects of treatment are of concern. Young people have a particular interest in the impact of chemotherapy or radiotherapy on their future fertility, and recent media reports1 of the successful transplantation of cryopreserved autologous ovarian tissue into a previously oophorectomised woman with non-malignant disease (K Oktay et al, Annual Meeting of American Society for Reproductive Medicine, Toronto, September 1999) will have caught the imagination of many. If a technique works in this situation, why not for a woman with malignancy whose ovarian tissue might be harvested before the start of sterilising chemotherapy?

Successful transplantation of cryopreserved ovarian cortical tissue into castrated ewes was first performed by Gosden and colleagues in 19942: a return of oestrus cycles was observed, and, after normal mating, conceptions occurred and lambs were born. Further work in women suggests that small pieces of …
Master of the Dresden Prayer Book
Authors: M Therese Southgate
Journal: JAMA (2005)

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Task force 4: Appropriate clinical care and issues of “self-referral”
Authors: James L. Ritchie, Michael J. Wolk, John W. Hirshfeld, Joseph V. Messer, Eric D. Peterson, Eric N. Prystowsky, Timothy J. Gardner, Harry R. Kimball, Richard L. Popp, Lynn Smaha, Sidney C. Smith, L.Samuel Wann
Journal: Journal of the American College of Cardiology (2004)