THE MECHANICS OF BREATHING IN NORMAL SUBJECTS AND IN PATIENTS WITH CARDIOPULMONARY DISEASE
Authors: E O ATTINGER, M M GOLDSTEIN, M S SEGAL
Journal: Annals of Internal Medicine (1958)

Article1 June 1958THE MECHANICS OF BREATHING IN NORMAL SUBJECTS AND IN PATIENTS WITH CARDIOPULMONARY DISEASEERNST O. ATTINGER, M.D., MERRILL M. GOLDSTEIN, M.D., MAURICE S. SEGAL, M.D., F.A.C.P.ERNST O. ATTINGER, M.D.Search for more papers by this author, MERRILL M. GOLDSTEIN, M.D.Search for more papers by this author, MAURICE S. SEGAL, M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-48-6-1269 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptA number of reports have appeared during recent years on the changes of the physical properties of the lung in cardiopulmonary diseases.1-26 Valuable new information has been obtained on the fundamental nature of different disorders, though only a comparatively small number of subjects have been studied. It is the purpose of this report to describe the results on a series of 100 subjects: 25 normal subjects and 75 patients with various types of cardiopulmonary disease.MATERIAL AND METHODSThe subjects were studied in the basal state and in the supine position. Transpulmonary pressures, instantaneous air flow rates and tidal volumes...Bibliography1. MeadWhittenberger JJL: Physical properties of human lungs measured during spontaneous respiration, J. Appl. Physiol. 5: 779, 1953. CrossrefGoogle Scholar2. McIlroyMarshallChristie MBRRV: The work of breathing in normal subjects, Clin. Sc. 13: 127, 1954. MedlineGoogle Scholar3. DuBoisBotelhoComroe ABSYJH: A new method for measuring airway resistance in man using a body plethysmograph: values in normal subjects and in patients with respiratory disease, J. Clin. Investigation 35: 327, 1956. CrossrefMedlineGoogle Scholar4. FrankMeadSiebensStorey NRJAACF: Measurement of pulmonary compliance in 70 healthy young adults, J. Appl. Physiol. 9: 38, 1956. CrossrefMedlineGoogle Scholar5. CookCherryO'BrienKarlbergSmith CDRBDPCA: Studies of respiratory physiology in the newborn infant. I. Observations on normal, premature and full-term infants, J. Clin. Investigation 34: 975, 1955. CrossrefMedlineGoogle Scholar6. McIlroyTomlinson MBES: The mechanics of breathing in newly born babies, Thorax 10: 58, 1955. CrossrefMedlineGoogle Scholar7. MarshallChristie RRV: The visco-elastic properties of the lungs in acute pneumonia, Clin. Sc. 13: 403, 1954. MedlineGoogle Scholar8. Dayman H: Mechanics of airflow in health and in emphysema, J. Clin. Investigation 30: 1175, 1951. CrossrefMedlineGoogle Scholar9. SteadFryEbert WMDLRV: The elastic properties of the lung in normal men and in patients with chronic pulmonary emphysema, J. Lab. and Clin. Med. 40: 674, 1952. MedlineGoogle Scholar10. FryEbertSteadBrown DLRVWMCC: The mechanics of pulmonary ventilation in normal subjects and in patients with emphysema, Am. J. Med. 16: 80, 1954. CrossrefMedlineGoogle Scholar11. McIlroyChristie MBRV: The work of breathing in emphysema, Clin. Sc. 13: 147, 1954. MedlineGoogle Scholar12. MeadLindgrenGaensler JIEA: The mechanical properties of the lungs in emphysema, J. Clin. Investigation 34: 1005, 1955. CrossrefMedlineGoogle Scholar13. Cherniak RM: The physical properties of the lung in chronic obstructive pulmonary emphysema, J. Clin. Investigation 35: 394, 1956. CrossrefMedlineGoogle Scholar14. AttingerGoldsteinSegal EOMMMS: Ventilation in chronic pulmonary emphysema. II. Correlation of compliance and mechanical resistance with routine pulmonary function tests, Am. Rev. Tuberc. and Pul. Dis. 74: 220, 1956. Google Scholar15. Neolpp-EschenhagenNoelpp IB: New contributions to experimental asthma, Progress in Allergy 4: 361, 1954. Google Scholar16. NoelppNoelpp-EschenhagenLottenbach BIK: Das Verhalten der elastischen Lungenspannung und des Gewebs-Deformationswiderstandes bei der experimentellen asthmatiformen Dyspnoe, Internat. Arch. Allergy 5: 245, 1954. CrossrefGoogle Scholar17. McIlroyMarshall MBR: The mechanical properties of the lungs in asthma, Clin. Sc. 15: 345, 1956. MedlineGoogle Scholar18. MarshallMcIlroyChristie RMBRV: The work of breathing in mitral stenosis, Clin. Sc. 13: 137, 1954. MedlineGoogle Scholar19. BrownFryEbert CCDLRV: The mechanics of pulmonary ventilation in patients with heart disease, Am. J. Med. 17: 438, 1954. CrossrefMedlineGoogle Scholar20. HaywardKnott GWJM: The effect of exercise on lung distensibility and respiratory work in mitral stenosis, Brit. Heart J. 17: 303, 1955. CrossrefMedlineGoogle Scholar21. SaxtonRabinowitzDexterHaynes GAMLF: The relationship of pulmonary compliance to pulmonary vascular pressures in patients with heart disease, J. Clin. Investigation 35: 611, 1956. CrossrefMedlineGoogle Scholar22. OtisBembower ABWC: Effect of gas density on resistance to respiratory gas flow in man, J. Appl. Physiol. 2: 300, 1949. CrossrefMedlineGoogle Scholar23. OtisRahnFenn ABHWO: Venous pressure changes associated with positive intrapulmonary pressure: their relationship to the distensibility of the lung, Am. J. Physiol. 146: 307, 1946. CrossrefMedlineGoogle Scholar24. FerrisMeadWhittenbergerSaxton BJJLGA: Pulmonary function in convalescent polio patients, New England J. Med. 247: 390, 1952. CrossrefMedlineGoogle Scholar25. ScherrerKostyalWierzejewskiSchmidtGeuns MAHFHA: Zur Pathophysiologie des provozierten bronchial-asthmatischen Anfalls, Internat. Arch. Allergy 9: 65, 1956. CrossrefGoogle Scholar26. MarshallDuBois RAB: The viscous resistance of lung tissue in patients with pulmonary disease, Clin. Sc. 15: 473, 1956. MedlineGoogle Scholar27. AttingerMonroeSegal EORGMS: The mechanics of breathing in different body positions. I. In normal subjects, J. Clin. Investigation 35: 904, 1956. CrossrefMedlineGoogle Scholar28. BaldwinCournandRichards EDADW: Pulmonary insufficiency. I. Physiological classification, clinical methods of analysis, standard values in normal subjects, Medicine 27: 243, 1948. CrossrefMedlineGoogle Scholar29. AttingerDow EOJ: The relation of intrathoracic pressure changes to respiratory pressure changes within the pulmonary vasculature, to be published. Google Scholar30. OtisMcKerrowBartlettMeadMcIlroySelverstoneRadford ABCBRAJMBNJEP: Mechanical factors in distribution of pulmonary ventilation, J. Appl. Physiol. 8: 427, 1956. CrossrefMedlineGoogle Scholar31. AttingerSegal EOMS: Ventilation and the mechanics of breathing in clinical cardiopulmonary physiology, edited by Gordon, B., 1957, Grune & Stratton, Inc., New York. Google Scholar32. AttingerHerschfusSegal EOAJMS: Mechanics of breathing in different body positions. II. In patients with cardiopulmonary disease, J. Clin. Investigation 35: 912, 1956. CrossrefMedlineGoogle Scholar33. ButlerArnott JWM: The work of pulmonary ventilation at different respiratory levels, Clin. Sc. 14: 703, 1955. MedlineGoogle Scholar34. MarshallDuBois RAB: The measurement of the viscous resistance of the lung tissues in normal man, Clin. Sc. 15: 161, 1956. MedlineGoogle Scholar35. O'NealThomasLeeRabin RMWAKTER: Alveolar walls in mitral stenosis, Circulation 15: 64, 1957. CrossrefMedlineGoogle Scholar36. BondurantHickam SJB: Pulmonary and circulatory effects of acute pulmonary vascular engorgement in normal subjects, J. Clin. Investigation 35: 692, 1956 (abstract). Google Scholar37. MackGrossmanKatz IMLN: The effect of pulmonary vascular congestion on the distensibility of the lungs, Am. J. Physiol. 150: 654, 1947. CrossrefMedlineGoogle Scholar38. Gaensler EA: Air velocity index: numerical expression of functionally effective position of ventilation, Am. Rev. Tuberc. 62: 17, 1950. MedlineGoogle Scholar39. D'Silva JL: Mechanical function of the lungs, Brit. J. Phys. Med. 15: 129, 1952. Google Scholar40. Bernstein L: The discontinuity in the pressure-volume curve of the rabbit's lung, J. Physiol. 124: 35, 1954. MedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: ERNST O. ATTINGER, M.D.; MERRILL M. GOLDSTEIN, M.D.; MAURICE S. SEGAL, M.D., F.A.C.P.Affiliations: Boston, Massachusetts*Received for publication May 1, 1957.From the Department of Medicine, Tufts University School of Medicine, and the Lung Station (Tufts) and Department of Inhalation Therapy, Boston City Hospital, Boston, Massachusetts.†Work done during tenure of a Research Fellowship of the American Heart Association.Requests for reprints should be addressed to Maurice S. Segal, M.D., Department of Inhalation Therapy, Boston City Hospital, Boston 18, Massachusetts. 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