tbuckley/cabot-search huggingface dataset:
Tumor Induction in Transplanted Tooth Buds Infected With Polyoma Virus
Authors: James H. P. Main, Clyde J. Dawe
Journal: JNCI Journal of the National Cancer Institute (1966)

Mandibular and maxillary incisor tooth buds from 14-day embryos of strain C3H/Bi mice were infected with strain LID/1 polyoma virus and transplanted to newborn syngeneic recipients. Uninfected tooth buds were transplanted to similar newborn recipients as controls. Ameloblastomas developed from infected transplants in 15 of 39 recipients, but none from the uninfected transplants in 52 control recipients. The tumors were found between 20 and 72 days after transplantation of the infected buds. Tooth development occurred in 10 of 39 infected transplants (3 to 4 buds each) and in 40 of 52 uninfected transplants (also 3–4 buds each). Epithelial cysts alone developed in infected transplants in 21 of 39 recipients, and in uninfected transplants in 6 of 52 recipients. Viral infection was thus associated with reduction in frequency and extent of tooth development from transplants. Ameloblastomas developed in some infected transplants in which no tooth development was found in serial sections. Presumably these tumors arose from epithelium with ameloblastic potential, lining the cysts associated with them. Histologically they were closely similar to the tumors associated with developed teeth. Ameloblastomas arose from teeth in situ in all of the infected host animals surviving more than 20 days. The tumors appeared to originate from the outer enamel epithelium. Three sarcomas were Found, 2 of which apparently arose from dental pulp and 1 from periodontal membrane. These were coexistent with ameloblastomas in each instance.
Effect of Heavy Metals on the In Vitro Cytotoxicity of 3-Ethoxy-2-Oxobutyraldehyde Bis(Thiosemicarbazone) and Related Compounds
Authors: G. J. Van Glessen, J. A. Crim, D. H. Petering, H. G. Petering
Journal: JNCI Journal of the National Cancer Institute (1973)

We studied the effect of trace metals on the in vitro cytotoxicity of 3-ethoxy-2-oxobutyraldehyde bis(thiosemicarbazone) (H2KTS) and several related thiosemicarbazones, using a modification of the Arai-Suzuki test system in which metal ion concentrations are rigidly controlled. In the absence of trace metal ions, none of the compounds was cytotoxic, but several became highly cytotoxic in the presence of nontoxic levels of Cu2+ or Zn2+. The ability of either cupric or zinc ion to potentiate the activity of derivatives of 3-ethoxy-2-oxobutyraldehyde and pyruvaldehyde depended on whether the thlcsemlccrbczene groups were methylated at the N4 position. Among several metal chelates of H2KTS, only the cupric, cuprous, and mercuric chelates had appreciable effects and these were increased by the presence of cupric ion. The in vitro cytotoxicity of H2KTS to Walker 256 tumor cells in the presence of cupric ions correlates with the inability of similarly treated tumor cells to grow when implanted into rats. The cytotoxic form of each active compound appears to be the chelate of the metal activating that compound.
The regional distribution of body fat mass (BFM) in men with chronic obstructive pulmonary disease (COPD)
Authors: Aliaksandr Makarevich, Sviatlana Lemiasheuskaya
Journal: European Respiratory Journal (2011)

Introduction:  COPD is associated with abnormal body composition and weight loss.   Aim:  To evaluate the relations between BFM distribution and lung function in men during COPD progression.   Methods:  We used dual-energy X-ray absorptionmetry for analyze of a body composition, the regional distribution of BFM as well as fat mass ratios of Android/Gynoid (A/G) and Arms+Legs/trunk. COPD pts (aged 40-69 yrs) were divided into the 3 groups according to disease severity: the 1st was made of 14 men (GOLD I stage; mean age 55 yrs; FEV 1  78%; BMI 27 kg/m 2 , smokers 68%, packs/yrs 20); the 2nd - 43 pts (GOLD II stage; mean age 57; FEV 1  63%; BMI 28 kg/m 2 , smokers 80%, packs/yrs 21); the 3rd - 20 pts (GOLD III stage; mean age 60 yrs; FEV 1  41%; BMI 24 kg/m 2 , smokers 84%, packs/yrs 28). The control group was formed of 15 healthy men (mean age 56 yrs and BMI 26 kg/m 2 , smokers 66%, packs/yrs 20).   Results:  The A/G ratio was significantly lower in 3rd group vs. the control (1,1±0,3 vs. 1,3±0,2 respectively). This ratio in the 1st and 2nd groups did not differ from the control value. The similar picture was observed concerning Fat trunk%. Thus this level was 25±10 in 3rd group vs. 34±8 in the control group (p=0,02). The Arms + Legs/trunk ratio was higher in 3rd group as compare with the control (0,76±0,3 vs. 0,60±0,1; p=0,03). This ratio in the 1st and 2nd groups did not differ from the control. We detected the negative significant correlations between A/G ratio and packs/yrs index (r= -0,44) as well as among Arms+Legs/trunk ratio and FEV 1  (r= -0,33).   Conclusions:  BFM redistribution (decrease A/G ratio and increase Arm+Leg/trunk ratio) take place in the course of COPD progression.
Irinotecan Therapy in Adults With Recurrent or Progressive Malignant Glioma
Authors: Henry S. Friedman, William P. Petros, Allan H. Friedman, Larry J. Schaaf, Tracy Kerby, Jennifer Lawyer, Mary Parry, Peter J. Houghton, Shelley Lovell, Karima Rasheed, Tim Cloughsey, Elizabeth S. Stewart, O. Michael Colvin, James M. Provenzale, Roger E. McLendon, Darell D. Bigner, Ilkcan Cokgor, Michael Haglund, Jeremy Rich, David Ashley, Joseph Malczyn, Gary L. Elfring, Langdon L. Miller
Journal: Journal of Clinical Oncology (1999)

PURPOSE: To determine the activity, toxicity, and pharmacokinetics of irinotecan (CPT-11, Camptosar; Pharmacia &amp; Upjohn, Kalamazoo, MI) in the treatment of adults with progressive, persistent, or recurrent malignant glioma. PATIENTS AND METHODS: Patients with progressive or recurrent malignant gliomas were enrolled onto this study between October 1996 and August 1997. CPT-11 was given as a 90-minute intravenous (IV) infusion at a dose of 125 mg/m 2 once weekly for 4 weeks followed by a 2-week rest, which comprised one course. Plasma concentrations of CPT-11 and its metabolites, SN-38 and SN-38 glucuronide (SN-38G), were determined in a subset of patients. RESULTS: All 60 patients who enrolled (36 males and 24 females) were treated with CPT-11 and all were assessable for toxicity, response, and survival. Pharmacokinetic data were available in 32 patients. Nine patients (15%; 95% confidence interval, 6% to 24%) had a confirmed partial response, and 33 patients (55%) achieved stable disease lasting more than two courses (12 weeks). Toxicity observed during the study was limited to infrequent neutropenia, nausea, vomiting, and diarrhea. CPT-11, SN-38, and SN-38G area under the plasma concentration-time curves through infinite time values in these patients were approximately 40%, 25%, and 25%, respectively, of those determined previously in patients with metastatic colorectal cancer not receiving antiepileptics or chronic dexamethasone treatment. CONCLUSION: Response results document that CPT-11, given with a standard starting dose and treatment schedule, has activity in patients with recurrent malignant glioma. However, the low incidence of severe toxicity and low plasma concentrations of CPT-11 and SN-38 achieved in this patient population suggest that concurrent treatment with anticonvulsants and dexamethasone enhances drug clearance.
CTX-M-15-non-ST131 Escherichia coli isolates are mainly responsible of faecal carriage with ESBL-producing Enterobacteriaceae in travellers, immigrants and those visiting friends and relatives
Authors: A. Valverde, M.-C. Turrientes, F. Norman, E. San Martín, L. Moreno, J.A. Pérez-Molina, R. López-Vélez, R. Cantón
Journal: Clinical Microbiology and Infection (2014)
The Death Burden and End-of-Life Care Intensity Among Adolescent and Young Adult Patients With Cancer
Authors: Archie Bleyer
Journal: JAMA Oncology (2015)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Oncology HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Oncology journal
Mechanisms of Antitumor Action of Corynebacterium parvum : Nonspecific Tumor Cell Destruction at Site of an Immunologically Mediated Sensitivity Reaction to C. parvum 2
Authors: Richard L. Tuttle, Robert J. North
Journal: JNCI Journal of the National Cancer Institute (1975)

Mice immunized in the footpad with Corynebacterium parvum developed a systemic mechanism with a potential for destroying syngeneic tumor cells. The development of this mechanism of antitumor action depended on the generation of a state of systemic sensitivity to C. parvum antigens, which allowed an immunologically mediated inflammatory response to be focused at the site of a tumor cell challenge or in the bed of an established tumor. This resulted in complete inhibition of growth of the former regression of the latter. This nonspecific mechanism of tumor cell destruction could be utilized only during a relatively short period when mice were responding maximally to the organism. This corresponded to a period during which there was maximum cell division in the lymph node draining the site of immunization with C. parvum, maximum systemic macrophage activation, and maximum sensitivity to eliciting injections of the organism. The potential for destroying tumor cells could be transferred to normal recipients with lymph node cells from C. parvum-immunized donors, which indicated the distinct possibility that antitumor action was based on the cell-mediated response to C. parvum antigens. That the destruction of tumor cells at the site of a C. parvum sensitivity reaction was associated with a massive influx of mono-nuclear cells provided further support for this possibility.
Continuous Cell Culture From a Patient With Chronic Myelogenous Leukemia. I. Propagation and Presence of Philadelphia Chromosome
Authors: Linda S. Lucas, Jacqueline J. K. Whang, J. H. Tjio, Robert A. Manaker, Victor H. Zeve
Journal: JNCI Journal of the National Cancer Institute (1966)

A continuous culture, designated the M-2 line, was established from white cells from the peripheral blood of a patient with chronic myelogenous leukemia. The cells grew singly and in aggregates unattached to the surfaces of the culture vessel. During logarithmic growth, the cell doubling time was about 24 hours. The maximal viable cell concentration observed was about 1 × 106 cells per ml. Cells could be grouped into 3 categories according to size. About 23% of the cells contained the Philadelphia chromosome without other chromosome abnormalities. Some of the remaining cells contained a small metacentric chromosome and others had 44–48 chromosomes and an abnormal karyotype. Polyploidy and multiple chromosomal aberrations were in 15–20% of the cells.
Effect of the Ebola-virus-disease epidemic on malaria case management in Guinea, 2014: a cross-sectional survey of health facilities
Authors: Mateusz M Plucinski, Timothée Guilavogui, Sidibe Sidikiba, Nouman Diakité, Souleymane Diakité, Mohamed Dioubaté, Ibrahima Bah, Ian Hennessee, Jessica K Butts, Eric S Halsey, Peter D McElroy, S Patrick Kachur, Jamila Aboulhab, Richard James, Moussa Keita
Journal: The Lancet Infectious Diseases (2015)

The ongoing west Africa Ebola-virus-disease epidemic has disrupted the entire health-care system in affected countries. Because of the overlap of symptoms of Ebola virus disease and malaria, the care delivery of malaria is particularly sensitive to the indirect effects of the current Ebola-virus-disease epidemic. We therefore characterise malaria case management in the context of the Ebola-virus-disease epidemic and document the effect of the Ebola-virus-disease epidemic on malaria case management.We did a cross-sectional survey of public health facilities in Guinea in December, 2014. We selected the four prefectures most affected by Ebola virus disease and selected four randomly from prefectures without any reported cases of the disease. 60 health facilities were sampled in Ebola-affected and 60 in Ebola-unaffected prefectures. Study teams abstracted malaria case management indicators from registers for January to November for 2013 and 2014 and interviewed health-care workers. Nationwide weekly surveillance data for suspect malaria cases reported between 2011 and 2014 were analysed independently. Data for malaria indicators in 2014 were compared with previous years.We noted substantial reductions in all-cause outpatient visits (by 23 103 [11%] of 214 899), cases of fever (by 20249 [15%] of 131 330), and patients treated with oral (by 22 655 [24%] of 94 785) and injectable (by 5219 [30%] of 17 684) antimalarial drugs in surveyed health facilities. In Ebola-affected prefectures, 73 of 98 interviewed community health workers were operational (74%, 95% CI 65-83) and 35 of 73 were actively treating malaria cases (48%, 36-60) compared with 106 of 112 (95%, 89-98) and 102 of 106 (96%, 91-99), respectively, in Ebola-unaffected prefectures. Nationwide, the Ebola-virus-disease epidemic was estimated to have resulted in 74 000 (71 000-77 000) fewer malaria cases seen at health facilities in 2014.The reduction in the delivery of malaria care because of the Ebola-virus-disease epidemic threatens malaria control in Guinea. Untreated and inappropriately treated malaria cases lead to excess malaria mortality and more fever cases in the community, impeding the Ebola-virus-disease response.Global Fund to Fight AIDS, Tuberculosis and Malaria, and President's Malaria Initiative.
Respiratory symptoms in damp homes
Authors: M. Waegemaekers, N. van Wageningen, B. Brunekreef, J. S. M. Boleij
Journal: Allergy (1989)

The association between living in damp homes and the prevalence of health symptoms was investigated in a population of 519 occupants (adults and children) of 185 homes. Positive associations were found between the reporting of respiratory and some other health symptoms and living in a damp home. The concentration of vaiable mould spores in indoor air was measured, using modified Andersen samplers, in the living rooms of a sample of 36 homes. The results were compared with the occurrence of dampness characteristics in their homes as reported by the occupants. Homes with at least two dampness characteristics showed higher average spore counts and higher prevalence of respiratory symptoms.
Genetic association of<i>HLA‐DQB1</i>and<i>HLA‐DRB1</i>polymorphisms with alopecia areata in the Italian population
Authors: F. Megiorni, A. Pizzuti, B. Mora, A. Rizzuti, V. Garelli, C. Maxia, M. Carlesimo, M.C. Fotruna, R. Delle Chiaie, G. Cavaggioni, A. Rossi
Journal: British Journal of Dermatology (2011)

Alopecia areata (AA) is a multifactorial disease characterized by hair loss especially from the scalp. As for other autoimmune conditions, the major histocompatibility complex (HLA) region is associated with AA susceptibility.To provide evidence for the association of specific HLA-DQB1 and HLA-DRB1 alleles with AA in an Italian population, using a case-control approach.We performed a case-control study to investigate whether HLA-DQB1 and -DRB1 alleles predispose to AA in the Italian population. HLA class II typing was performed in 85 patients with AA and 210 healthy controls from the same ethnic group.An increased frequency of DQB1*03, coding for DQ7 heterodimers, and a decreased rate of the DQB1*06 allele were observed in patients when compared with controls; the greatest and significant difference was in the group of cases with a more severe phenotype [AA>50% patients (more than 50% hair loss) vs. controls, P=4·5×10(-3) , P(c)=0·031, odds ratio (OR) 2·01, 95% confidence interval (CI) 1·22-3·31 and P=2·5×10(-3) , P(c)=0·017, OR 0·22, 95% CI 0·07-0·72, respectively]. DQB1*03, serologically related to DQ8 or coding for DQ9 molecules, was not associated with AA susceptibility. Out of all patients, 65·9% carried DQ7 heterodimers compared with 49·5% of the controls (P=7·3×10(-3) , OR 1·97, 95% CI 1·17-3·32) and DQ7 prevalence rose to 76·3% in patients with AA>50% (P=1·7×10(-3) , OR 3·28, 95% CI 1·48-7·27). No significant difference was found in the distribution of DRB1 variants or phenotypes among cases and controls.Our data show a correlation between the HLA-DQB1 locus and the occurrence of AA in Italy supporting DQB1*03(DQ7) as a predisposing allele for the disease and the relevance of the HLA genetic test in the clinical management of AA.
A regulatory CD9<sup>+</sup>B-cell subset inhibits HDM-induced allergic airway inflammation
Authors: F Braza, J Chesne, M Durand, S Dirou, C Brosseau, G Mahay, M A Cheminant, A Magnan, S Brouard
Journal: Allergy (2015)

Background Exposure to respiratory allergens triggers airway hyperresponsiveness and inflammation characterized by the expansion of TH2 cells and the production of allergen specific IgE. Allergic asthma is characterized by an alteration in immune regulatory mechanisms leading to an imbalance between pro- and anti-inflammatory components of the immune system. Aims Recently B cells have been described as central regulators of exacerbated inflammation, notably in the case of autoimmunity. However, to what extent these cells can regulate airway inflammation and asthma remains to be elucidated. Materials & Methods We took advantage of a allergic asthma model in mice induced by percutaneous sensitization and respiratory challenge with an extract of house dust mite. Results In this study, we showed that the induction of allergic asthma alters the homeostasis of IL-10+ Bregs and favors the production of inflammatory cytokines by B cells. Deeper transcriptomic and phenotypic analysis of Bregs revealed that they were enriched in a CD9+ B cell subset. In asthmatic mice the adoptive transfer of CD9+ B cells normalized airway inflammation and lung function by inhibiting TH2- and TH17-driven inflammation in an IL-10-dependent manner, restoring a favorable immunological balance in lung tissues. Indeed we further showed that injection of CD9+ Bregs controls the expansion of lung effector T cells allowing the establishment of a favorable regulatory T cells/effector T cells ratio in lungs. Conclusion This finding strengthens the potential for Breg-targeted therapies in allergic asthma.
Mir Profiling Identifies Cdk6 Down-Regulation As a Potential Mechanism of Acquired Cisplatin Resistance in Non-Small Cell Lung Carcinoma
Authors: J. Bar, I. Gorn-Hondermann, P. Moretto, N. Niknejad, D.J. Stewart, G.D. Goss, J. Dimitroulakos
Journal: Annals of Oncology (2014)
Comparative Studies on the Interaction of Benzo[&lt;italic&gt;a&lt;/italic&gt;]pyrene With Cells Derived From Poikilothermic and Homeothermic Vertebrates. I. Metabolism of Benzo[&lt;italic&gt;a&lt;/italic&gt;]pyrene&lt;xref ref-type="fn" rid="FN2"&gt;2&lt;/xref&gt;
Authors: Leila Diamond, H. Fred Clark
Journal: JNCI Journal of the National Cancer Institute (1970)

The metabolism of benzo[a]pyrene (BP) to water-soluble derivatives was measured in cell cultures derived from poikilothermic and homeothermic vertebrates. Tritiated BP was added to the cultures and, after 24 hours of incubation, the medium was extracted with chloroform:methanol:water. The amount of BP metabolized per cell (relative efficiency of metabolism) was calculated from the 3H-BP equivalents in the aqueous phase of the extraction mixture. Many poikilothermic vertebrate cell cultures, including those derived from fish, toad, lizard, and turtle, were able to metabolize BP. In some instances, metabolism was as efficient as in rodent cell cultures. Cell multiplication was inhibited by BP, only in those cultures in which the metabolism of BP was highly efficient. Conversely, cytotoxicity was not observed in cell cultures with little or no ability to metabolize the carcinogen.
Authors' response
Authors: Shomron Ben-Horin, Yehuda Chowers
Journal: Gut (2011)

We thank Dr Vande Casteele and colleagues for their interest in our work and commend them for their interesting case.1 2 As written in our manuscript, we have had several, and in some cases serial, measurements of infliximab and antidrug antibody (ADA) levels in the patients reported. However, we limited the results to the last sample available before loss of response occurred to better meet the aim of the study, which was to investigate the immunogenic fragment of infliximab and its possible diagnostic role …
Evolution of immunological occupational asthma depending on the continuation or end of exposure
Authors: Xavier Munoz, Meritxell Viladrich, Luis Manso, Victoria del Pozo, Santiago Quirce, Maria-Jesus Cruz, Joaquin Sastre
Journal: European Respiratory Journal (2012)

INTRODUCTION: It is generally agreed that the best treatment after diagnosis of occupational asthma (OA) is avoidance of exposure to the causal agent. However, recent meta-analyses have raised doubts about this conclusion. The aim of the present study is to assess the evolution of OA depending on whether or not the patient avoids exposure.

METHODS: Multicentre, cross-sectional clinical follow-up study in patients diagnosed with OA using a specific inhalation challenge (SIC) between January 2000 and December 2009. Patients with this diagnosis received the following examinations on the same day: clinical interview, physical examination, forced spirometry, methacholine test and determination of total IgE and IgE specific to the causal agent. CIinical improvement, deterioration or no change were defined according to the changes seen in the GINA severity scale at the time of diagnosis.

RESULTS: Of the 73 patients finally included, 55 had totally ended exposure and 18 continued. The mean time elapsed since diagnosis was 48 months (range: 12 – 123). Forty-two per cent of patients who avoided exposure improved clinically, 38% presented no change, and 14% deteriorated. In the patients who did not avoid exposure improvement was recorded in 22%, deterioration in 17% and no change in 61%. No significant differences in methacholine PC20 or FEV1 were detected between both groups.

CONCLUSIONS: Avoiding exposure to the causal agent in patients with OA does not seem to improve prognosis in this disease.

Project partially funded by Ciber de Enfermedades Respiratorias (CibeRes).