tbuckley/cabot-search huggingface dataset:
The academic base for general practice: the case for change.
Authors: J Allen, A Wilson, R Fraser, D P Gray
Journal: BMJ (1993)

University departments of general practice and the postgraduate education system for general practice have developed separately over the past 30 years. This separation is now impeding the academic development of the discipline and causes difficulties with recruitment and career progression. These problems could be eased by the creation of integrated departments. This would establish a critical mass for research and educational development, allow human and other resources to be used more flexibly and effectively, and provide a strong base for undergraduate education, vocational training, higher professional training, and continuing education. It could encourage collaborative ventures with other disciplines and also lead to higher standards of patient care.
Abstract 2809: BMS-777607, a small molecule RON/MET kinase inhibitor induces polyploidy in breast cancer cells: molecular mechanism and therapeutic implication
Authors: Sharad Sharma, Chun-Mei Zhuang, Junying Zeng, Minghai Wang
Journal: Cancer Research (2012)

Abstract Aberrant RON expression contributes significantly to breast cancer tumorigenic progression. This observation has provided the basis for targeting RON in potential breast cancer treatment. In the study of breast cancer tumorigenesis, we discovered that inhibition of RON by small molecule inhibitor BMS-777607 causes polyploidy followed by apoptosis in various breast cancer cells including T-47D and ZR-75-1. BMS-777607 is a tyrosine kinase inhibitor specific to RON and MET receptor tyrosine kinases and blocks cancer cell proliferation in vitro and tumor growth in xenograft model in vivo. Using breast cancer cells as the model, we observed that BMS-777607 at experimental doses induces extensive polyploidy and apoptosis in breast cancer cells. The effect of BMS-777607 has the following features. First, BMS-777607 treatment dramatically altered cell morphology, increased cell size, and created multinucleate structures. Chromosome spreading at metaphase and flow cytometric analysis confirmed polyploid cells with 6N to 16N chromosome content, indicating that abortive mitosis and endoreduplication are responsible for the observed polyploidy. Second, the effect of BMS-777607 was highly specific and dependent on RON or MET expression. MCF-7 cells that do not express RON/MET showed only low levels of polyploidy, suggesting that RON and MET expression are required for the observed polyploid activity. Third, the effect of BMS-777607 is time and dose-dependent. A substantial polyploid population of cells accumulated within 24 h of drug treatment. Continuous cycle of abortive mitosis further increased cell ploidy with increased 16N cell fractions. Moreover, an experimental dose of 500 nM is sufficient to induce polyploidy. The maximal effect occurred when BMS-777607 was used at 5.0 μM for 72 h. Fourth, polyploidy induction promoted apoptosis and senescence of breast cancer cells, which led to significant changes in cellular sensitivity towards cytotoxic activity of chemoagents. Finally, we demonstrated that Aurora B kinase is the major signaling molecule responsible for BMS-777607-induced cancer cell polyploidy. BMS-777607 inhibited Aurora B kinase activity, which affected mitosis leading to polyploidy. In summary, BMS-777607 is a potent inducer of polyploidy in breast cancer cells. By blocking RON/MET-mediated signaling events, BMS-777607 impaired Aurora B kinase activity leading to polyploidy and apoptosis. Such observations provide mechanistic and therapeutic insight in BMS-777607 targeted cancer therapy (*supported in part by NIH grant R01 CA91980 and funds from Amarillo Area Foundation). Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 103rd Annual Meeting of the American Association for Cancer Research; 2012 Mar 31-Apr 4; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2012;72(8 Suppl):Abstract nr 2809. doi:1538-7445.AM2012-2809
SERO-THERAPY AND ACCESSORY TREATMENTS OF TUBERCULOSIS.
Authors: PAUL PAQUIN
Journal: JAMA (1895)

In January last I had the honor to report to the St. Louis Medical Society, the result of my researches up to that time, on the action of a certain kind of serum in the treatment of tuberculosis. The clinical history of twenty-five cases treated six weeks or three months was given. Seven cases (four with cavities, among whom two had been bed-ridden and given up as absolutely hopeless), were brought to the Medical Society at night, in a weather rendered severe by the fall of a melting snow, and not one coughed during the two hours of their exhibition in a smoky room. It was then demonstrated that all of the twenty-five patients had been decidedly benefited; the least that had been done for a few of them was the arrest of the decline. Only four or five were benefited to this slight degree, while all the others, all
DO EXTREME RISK CASES IMPACT HOSPITALS&amp;apos; RISK-ADJUSTED PCI MORTALITY RATINGS? RESULTS FROM THE NCDR&amp;reg;
Authors: Eric D. Peterson, Dadi (David) Dai, Sean O&apos;Brien, J. Matthew Brennan, Kalon Ho, Frederick Masoudi, John Messenger, W. Douglas Weaver
Journal: Journal of the American College of Cardiology (2012)
Media-abetted liver transplants raise questions of 'equity and decency'
Authors: P. Gunby
Journal: JAMA (1983)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Proliferative lesions of the glandular stomach and liver in F344 rats fed diets containing Aroclor 1254.
Authors: J M Ward
Journal: Environmental Health Perspectives (1985)

Aroclor 1254 was fed to groups of 24 male and 24 female F344 rats, from 7 weeks of age, at dietary concentrations of 25, 50 and 100 ppm for up to 105 weeks. There was a dose- related depression of body weight gain for both sexes and decrease in survival for male rats. Histologically, an increased incidence of gastric intestinal metaplasia and adenocarcinoma was found in both sexes. Hepatocellular adenomas, carcinomas, and eosinophilic and vacuolated hepatocellular foci were usually found in dosed rats only. The number of these foci per unit area of liver was significantly increased in dosed rats, although eosinophilic foci were only found in rats exposed to Aroclor 1254. Basophilic hepatocellular foci were found in similar numbers per square centimeter of liver in controls and treated rats. This finding suggested that eosinophilic hepatocellular foci and tumors arose de novo rather than from the naturally occurring basophilic foci. The appearance of unique, potentially preneoplastic lesions and tumors in the liver and stomach in dosed rats which do not usually occur spontaneously in control rats would support the hypothesis that Aroclor 1254 induced or initiated these unique lesions de novo rather than promoted the growth of any naturally occurring lesions. Nonneoplastic hepatic lesions included degenerative hepatocellular changes and aggregates of macrophages with crystalline cytoplasmic structures and pigment granules.
Parietal Lobe Epileptic Focus Identified on SPECT-MRI Fusion Imaging in a Case of Epilepsia Partialis Continua
Authors: Robert Matthews, Dinko Franceschi, Wenlang Xia, Corazon Cabahug, Gail Schuman, Robert Bernstein, Robert Peyster
Journal: Clinical Nuclear Medicine (2006)

Epilepsia partialis continua, or "Kozhevnikov syndrome," is a rare condition characterized by persistent localized motor seizures usually localized in a distant limb. It is most often seen in children under 16 years old without gender preference. We report a 12-year-old girl with epilepsia partialis continua who presented to the emergency room after the onset of seizures. Routine electroencephalography (EEG) was performed with no clear ictal localization. Magnetic resonance imaging (MRI) was unremarkable. Ictal single photon emission computed tomography (SPECT) images with Tc-99m exametazime fused with MRI images revealed a parietal lobe epileptic focus within the superior segment of the postcentral gyrus. This case illustrates a rare disorder with an unusual epileptic localization identified by SPECT-MRI fusion.
Sudden Scrotal Edema in Cirrhosis: A Postparacentesis Syndrome
Authors: HAROLD O. CONN
Journal: Annals of Internal Medicine (1971)

Sudden, massive scrotal edema may occasionally occur after paracentesis in ascitic, cirrhotic patients. This syndrome is caused by the creation of a fistula between the peritoneal cavity and the subcutaneous tissues, with dissection of ascitic fluid between Camper's and Scarpa's fasciae downward into the continuous tissues of the scrotum. Variations of the syndrome occur in noncirrhotic patients with ascites of other causes, in women (sudden labial edema), and in the absence of paracentesis in patients who develop communications between the peritoneal and subcutaneous spaces (spontaneous scrotal edema). The distribution of edema depends on the site of paracentesis and the effect of gravity, for example, abdominal wall edema in supine patients, unilateral abdominal wall edema in patients who prefer lateral decubitus positions, and upper abdominal wall edema (Trendelenburg's position) and chest wall edema after thoracentesis. These syndromes may be avoided by using small needles and by avoiding skin sutures.
Late Complications of Amoebiasis
Authors: G. G. Turner
Journal: BMJ (1947)

SIR,-In the course of the session of the Royal Society Empire Scientific Conference, held last July, which was devoted to the consideration of greater uniformity in standards of measure- ment, the following resolution was adopted:" If textbooks and scientific data or memoirs are expressed in systems other than the metric, conversion factors or the metric equivalent should be included."The object which it was intended to achieve by the resolution was to make British scientific papers more intelligible to over- seas readers only familiar with the metric system.We should be grateful if you would arrange to bring this proposal to the attention of your Council in order that con- sideration may be given to the best means of implementing it.We would suggest that, should your Council or governing body be in general sympathy with the proposal, a meeting of those to whom this letter is addressed, or their representatives, should be called at a convenient date.At such a meeting any special points of difficulty arising could be discussed, and if possible a fairly uniform system worked out which could be recom- mended to the publishers of journals and textbooks.We would add that it is intended, as far as possible, to imple- ment the resolution in the reports of D.S.I.R. work
US health maintenance organisations: better care from non-profit plans
Authors: S. Gottlieb
Journal: BMJ (1999)

The quality of care provided by profit making health maintenance organisations in the United States is lower for several outcome measures than the quality of care provided by their non-profit making counterparts, reports a study published last week.

Researchers from the Center for National Health Program Studies at Boston's Cambridge Hospital compared the two types of health maintenance organisation on 14 quality measures, including immunisation rates, b blocker treatment for patients who had had a heart attack, mammography, and antenatal care (JAMA 1999;282: 159-63). They found that …
Mitral Stenosis, Massive Pulmonary Hemorrhage, and Emergency Valve Replacement
Authors: Raymond Schwartz, Ralph M. Myerson, L. Theodore Lawrence, Henry T. Nichols
Journal: New England Journal of Medicine (1966)

HEMOPTYSIS occurs quite frequently as a consequence of mitral stenosis, but massive, life-threatening pulmonary hemorrhage is distinctly unusual.1 2 3 4 5 6 Oppenheimer and Schwartz3 have termed its occurrence "paroxysmal pulmonary hemorrhage," and Wood4 referred to it as "pulmonary apoplexy." Such hemorrhage has resulted in fatal asphyxia from intrabronchial blood clots on rare occasions.7 , 8 Two cases of closed mitral commissurotomy performed as an emergency because of severe hemoptysis have been reported.9 , 10 In the case presented below, a serious threat of asphyxia was averted by the bronchoscopic removal of blood clots that formed casts of the entire tracheobronchial tree. Such extensive blood-cast formation represents a . . .
Evaluation of Heterosexual Partners, Children, and Household Contacts of Adults With AIDS
Authors: Margaret A. Fischl, Gordon M. Dickinson, Gwendolyn B. Scott, Nancy Klimas, Mary Ann Fletcher, Wade Parks
Journal: JAMA (1987)

Forty-five adults with the acquired immunodeficiency syndrome (AIDS) and their 45 spouses, 109 children, and 29 household contacts were studied for evidence of heterosexual, perinatal, and household spread of human T-cell lymphotropic virus type III (HTLV-III) infection. Of the 45 spouses enrolled, 26 (58%) had antibody to HTLV-III, including 12 (71%) of 17 male spouses and 14 (50%) of 28 female spouses. Of the 12 seropositive male spouses, nine were seropositive at enrollment and three had seroconversion. Of the 14 seropositive female spouses, four were seropositive at enrollment and ten seroconverted. Lack of barrier contraceptive use and oral sex were associated with seroconversion. Of the 109 children enrolled, 15 had AIDS or an AIDS-related illness, two had evidence of passive transfer of maternal antibodies, and two had HTLV-III infection acquired outside the household. None of the 90 seronegative children seroconverted. Of 29 household contacts studied, none developed antibody to HTLV-III. (<i>JAMA</i>1987;257:640-644)
Cutaneous γ/δ T-cell lymphoma: A histopathologic mimicker of lupus erythematosus profundus (lupus panniculitis)
Authors: Paula Aguilera, J.M. Mascaró, Antonio Martinez, Jordi Esteve, Susana Puig, Elias Campo, Teresa Estrach
Journal: Journal of the American Academy of Dermatology (2007)
Pitfalls in Linking Cost Sharing to Value
Authors: Fred I. Polsky
Journal: Annals of Internal Medicine (2008)

Letters5 February 2008Pitfalls in Linking Cost Sharing to ValueFred I. Polsky, MDFred I. Polsky, MDFrom Fred Polsky, MD, Consulting, Washington, DC 20016.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-148-3-200802050-00014 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:Braithwaite and Rosen (1) present an intriguing argument for enhancing patient adherence to “high-value” medical therapies, namely removal (or reduction) of cost-share obligations by the third party bearing risk. The authors correctly identify a major barrier to implementing their proposal—actuarial amortization of the added cost to the payer, when the “payback” (medical offset) from reduction in service utilization may occur with an uncertain time horizon, if at all.Payers in North America, Europe, and Australia have attempted a value-based copayment system within their prescription drug benefits in recent years, known as “reference-based pricing.” In this system, the ...References1. Braithwaite RS, Rosen AB. Linking cost sharing to value: an unrivaled yet unrealized public health opportunity. Ann Intern Med. 2007;146:602-5. [PMID: 17438319] LinkGoogle Scholar2. Ioannides-Demos LL, Ibrahim JE, McNeil JJ. Reference-based pricing schemes: effect on pharmaceutical expenditure, resource utilisation and health outcomes. Pharmacoeconomics. 2002;20:577-91. [PMID: 12141886] CrossrefMedlineGoogle Scholar3. 2004 Drug Trend Report. Maryland Heights, MO: Express Scripts; June 2005. Accessed at www.express-scripts.com/ourcompany/news/industryreports/drugtrendreport/2004/dtrFinal.pdf on 18 April 2007. Google Scholar Author, Article, and Disclosure InformationAuthors: Fred I. Polsky, MDAffiliations: From Fred Polsky, MD, Consulting, Washington, DC 20016.Disclosures: None disclosed. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoLinking Cost Sharing to Value: An Unrivaled Yet Unrealized Public Health Opportunity R. Scott Braithwaite and Allison B. Rosen Pitfalls in Linking Cost Sharing to Value R. Scott Braithwaite and Allison B. Rosen Metrics 5 February 2008Volume 148, Issue 3Page: 243-244KeywordsConflicts of interestDrug adherenceDrug pricesDrugsForecastingHealth careHealth information technologyTreatment guidelines ePublished: 5 February 2008 Issue Published: 5 February 2008 Copyright & PermissionsCopyright © 2008 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Dynamics of gene-modified progenitor cells analyzed by tracking retroviral integration sites in a human SCID-X1 gene therapy trial
Authors: Gary P. Wang, Charles C. Berry, Nirav Malani, Philippe Leboulch, Alain Fischer, Salima Hacein-Bey-Abina, Marina Cavazzana-Calvo, Frederic D. Bushman
Journal: Blood (2010)
PROSTATIC OBSTRUCTION: A SUGGESTED PROCEDURE FOR MORE ACCURATE DIAGNOSIS AND FOR THE TREATMENT OF SELECTED CASES
Authors: H. Williams
Journal: BMJ (1928)

In March, 1926, hie was seen again bv Dr. Davies, when there was a distinct recurrence of the optic neuritis, but no iritis; he had practically recovered by July, 1926, and ill the meantime had had a tonsil enucleated.
Tissue and cell imaging in situ: potential for applications in pathology and endoscopy
Authors: J-Y Scoazec
Journal: Gut (2003)

Morphological sciences have recently experienced a significant technological breakthrough that offers new opportunities for cell and tissue imaging in situ but also raises new challenges to pathologists, who must adapt to a rapidly evolving environment. New partners, such as cell and molecular biologists, have provided pathologists with highly powerful tools for cell and subcellular imaging. They include: (a) the adaptation of techniques derived from molecular biology and cytogenetics, (b) the development of new microscopic tools, such as confocal microscopy, and (c) the emergence of new preparative techniques, such as microdissection or tissue arrays. However, recent technological progresses in various fields, from endoscopy to genomics, also raise new challenges to pathologists. Pathologists must therefore be prepared to redefine their area of expertise: this will be achieved through a continuous collaboration with all the partners involved in cell and tissue imaging and analysis but also by emphasising the importance of the informations provided by cell and tissue imaging in situ.
Breast cancer screening: false positive rate is lower in older women
Authors: G Rubin, L. Garvican
Journal: BMJ (1998)

EDITOR —Werneke and McPherson1 question the detection rates of cancer observed in the breast screening programme in East Sussex, Brighton, and Hove that we reported in our recent paper.2 They suggest that these are the result of a high proportion of false positive screens. It is unfortunate that they did not consult us beforehand. The paper gives results of an ongoing study, but …
Angiotensin II-activated protein kinase C targets caveolae to inhibit aortic ATP-sensitive potassium channels
Authors: L SAMPSON, L DAVIES, R BARRETTJOLLEY, N STANDEN, C DART
Journal: Cardiovascular Research (2007)

Objective The vasoconstrictor angiotensin II (Ang II) acts at Gq/11-coupled receptors to suppress ATP-sensitive potassium (KATP) channel activity via activation of protein kinase C (PKC). The aim of this study was to determine the PKC isoforms involved in the Ang II-induced inhibition of aortic KATP channel activity and to investigate potential mechanisms by which these isoforms specifically target these ion channels.
Care of dying patients is improving, but access to palliative specialists varies
Authors: S. Mayor
Journal: BMJ (2011)

Just a fifth of hospitals in England had a member of their specialist palliative care service on site seven days a week during office hours in 2011 to support healthcare professionals caring for dying patients, an audit has found.

The audit, carried out by the Marie Curie Palliative Care Institute in Liverpool and the Royal College of Physicians, found that most trusts (92%) had access to telephone support out of hours but that only 20% had a face to face palliative care service available seven days a week. The audit team recommends that all hospital trusts should have a specialist palliative care service available to see dying patients if ward staff require support or advice on their care.

Deborah Murphy, associate director of the institute, said, “If ward staff need specialist advice, most have access to this by phone, but we consider it much better if members of …
Trafficking of Shiga toxin/Shiga-like toxin-1 in human glomerular microvascular endothelial cells and human mesangial cells
Authors: M. Warnier, W. Römer, J. Geelen, J. Lesieur, M. Amessou, L. van den Heuvel, L. Monnens, L. Johannes
Journal: Kidney International (2006)
Protein C concentrate prevents peripartum thrombosis
Authors: Marilyn Manco‐Johnson, Rachelle Nuss
Journal: American Journal of Hematology (1992)

Abstract A protein C deficient woman, with a past history of recurrent thrombosis and purpura fulminans, was successfully treated with protein C concentrate in the peripartum period. © 1992 Wiley‐Liss, Inc.
Familial chylomicronemia (type I hyperlipoproteinemia) due to a single missense mutation in the lipoprotein lipase gene.
Authors: D Ameis, J Kobayashi, R C Davis, O Ben-Zeev, M J Malloy, J P Kane, G Lee, H Wong, R J Havel, M C Schotz
Journal: Journal of Clinical Investigation (1991)

Complete deficiency of lipoprotein lipase (LPL) causes the chylomicronemia syndrome. To understand the molecular basis of LPL deficiency, two siblings with drastically reduced postheparin plasma lipolytic activities were selected for analysis of their LPL gene. We used the polymerase chain reaction to examine the nine coding LPL exons in the two affected siblings and three relatives. DNA sequence analysis revealed a single nucleotide change compared with the normal LPL cDNA: a G----A substitution at nucleotide position 680. This transition caused a replacement of glutamic acid for glycine at amino acid residue 142 of the mature LPL protein. Amino acid sequence comparisons of the region surrounding glycine-142 indicated that it is highly conserved among lipases from different species, suggesting a crucial role of this domain for the LPL structure. Expression studies of the mutant LPL cDNA in COS-7 cells produced normal amounts of enzyme mass. However, the mutated LPL was not catalytically active, nor was it efficiently secreted from the cells. This established that the Gly----Glu substitution at amino acid 142 is sufficient to abolish enzymatic activity and to result in the chylomicronemia syndrome observed in these patients.