tbuckley/cabot-search huggingface dataset:
Commissioning health education in primary care
Authors: Kristin McCarthy, Pamela Prentice
Journal: BMJ (2006)

Individuals in this situation need help and support to plan how and to whom they will disclose their status, and to find strategies for protecting others from infection.With a spouse or long term partner, suddenly refusing to have sex or requiring the use of condoms without explanation is unlikely to be effective, but disclosure of HIV status may lead to rejection, physical violence, and financial destitution.If word gets out into the community, perhaps through a sexual partner, individuals with HIV risk being ostracised, with their families taunted and their employment and entire existence under threat.Health professionals can advise and assist, but their patients, if fearful of prosecution, may be unwilling even to tell them if they are having difficulties avoiding unprotected sex. 4 An estimated 20 000 people in the United Kingdom have HIV infection that is still undiagnosed. 5here is a clear disincentive to testing when prosecution relies on defendants knowing they are infected.Meanwhile, those who do take the test may not agree to their partners being notified for fear of legal repercussions, thereby jeopardising essential public health control efforts.In addition, the threat to the confidentiality of data posed by criminal investigations may deter participation (or honesty) in the sexual behaviour research which provides an essential evidence base for HIV prevention.Doctors need guidance on whether the potential for criminal prosecutions changes their legal and ethical duty of confidentiality, and how to advise their HIV positive patients, who may become "victims" or "defendants" if a prosecution occurs.A briefing paper to inform clinicians is in preparation, a draft of which can be obtained from the British HIV Association. 6 Research evidence on the public health impact of criminal prosecutions for reckless transmission of HIV is limited, 7 and there is an urgent need for further research.Rates of uptake of HIV testing in groups at highest risk should be monitored to see whether criminalisation may be leading to reductions.In the short term, there is the opportunity to respond to the Crown Prosecution Service consultation.The draft guidance includes advice on how to
Contralateral pneumothorax with congenital diaphragmatic hernia.
Authors: D. G. Young
Journal: BMJ (1968)

Medical MemorandaMB~Rn 433the onset of neurological signs her gait had worsened.The left lower limb now showed a spastic paresis with an extensor plantar response.Impairment of all forms of cutaneous sensibility below the D 7 level on the right side completed the picture of a partial Brown-Sequard syndrome.The sensory loss was most dense over the L 3 dermatome, and there was a band of hyperaesthesia at D 6 of the left side.There were no motor signs in the right leg.The C.S.F. protein had risen to 500 mg./100 ml. and the cell count was 121/cu.mm., mainly lymphocytes.Spinal cord compression at the D 6 level was diagnosed and myelography undertaken by the lumbar route.The spinal block was partial and myelography was repeated by the cisternal route.
Leukocyte adsorptive apheresis for the treatment of active ulcerative colitis: A prospective, uncontrolled, pilot study
Authors: Hiroyuki Hanai, Fumitoshi Watanabe, Ken Takeuchi, Takayuki Iida, Masami Yamada, Yasushi Iwaoka, Abby Saniabadi, Isao Matsushita, Yoshihiko Sato, Kotaro Tozawa, Hajime Arai, Takahisa Furuta, Ken Sugimoto, Ingvar Bjarnason
Journal: Clinical Gastroenterology and Hepatology (2003)
Denileukin diftitox (ONTAK) induces a tolerogenic phenotype in dendritic cells and stimulates survival of resting Treg
Authors: Andreas S. Baur, Manfred B. Lutz, Stephan Schierer, Luca Beltrame, Gabi Theiner, Elisabeth Zinser, Christian Ostalecki, Gordon Heidkamp, Ina Haendle, Michael Erdmann, Manuel Wiesinger, Waltraud Leisgang, Stefanie Gross, Ansgar J. Pommer, Eckhart Kämpgen, Diana Dudziak, Alexander Steinkasserer, Duccio Cavalieri, Beatrice Schuler-Thurner, Gerold Schuler
Journal: Blood (2013)
Morphologic and immunohistochemical characterization of granulomas in the nucleotide oligomerization domain 2–related disorders Blau syndrome and Crohn disease
Authors: Carl E.I. Janssen, Carlos D. Rose, Gert De Hertogh, Tammy M. Martin, Brigitte Bader Meunier, Rolando Cimaz, Miroslav Harjacek, Pierre Quartier, Rebecca Ten Cate, Caroline Thomee, Valeer J. Desmet, Alain Fischer, Tania Roskams, Carine H. Wouters
Journal: Journal of Allergy and Clinical Immunology (2012)
Removal of Ticks
Authors: Joseph M. Benforado
Journal: JAMA (1984)

<h3>To the Editor.—</h3> The tenacious tick is ever with us.<sup>1,2</sup>Removal methods are part of the folklore, and, in my experience, the following empirically-derived technique has never failed to remove a skin-hugging tick (and its embedded mouthparts). I devised the method and used it almost daily when I was a camp physician years ago. The materials needed are a pocket knife (or similar blade), large nail (eight- to ten-penny size), and matches. The procedure is as follows. Warm the tip of the nail in a match flame. Slide the flat of the knife blade under the tick's abdomen. Place the heated nail tip on the tick's dorsal surface so that the beastie is sandwiched between the knife blade and the nail. When the tick's legs begin to wiggle (a response to the heat), turn the knife blade 90 degrees so that the tick, now at
Successful treatment of pemphigus vulgaris by pulsed intravenous immunoglobulin therapy
Authors: A.P. BEWLEY, M. KEEFE
Journal: British Journal of Dermatology (1996)

We report the successful treatment of a 36‐year‐old man with recalcitrant pemphigus vulgaris by pulsed intravenous immunoglobulin therapy, dexamethasone and cyclophosphamide. In addition to clinical resolution. Indirect immunofluorescence antibodies have since largely been undetectable.
Magnitude and time course of extracellular potassium inhomogeneities during acute ischemia in pigs. Effect of verapamil.
Authors: T A Johnson, C L Engle, L M Boyd, G G Koch, M Gwinn, L S Gettes
Journal: Circulation (1991)

Prior studies have demonstrated the presence of inhomogeneities in myocardial [K+]e after serial 10-minute occlusions of the left anterior descending coronary artery in the pig, even within restricted locations of an ischemic zone. These inhomogeneities are thought to underlie the electrophysiological abnormalities responsible for lethal ventricular arrhythmias through reentrant and nonreentrant pathways, but a clear association has not been demonstrated. As a prerequisite to establishing this association, these studies were performed to establish measurement standards for [K+]e inhomogeneity, to quantify the magnitude and time course of these inhomogeneities, to determine whether the inhomogeneities are greater in the ischemic border where lethal ventricular arrhythmias are known to originate, and to assess the effect of a known antifibrillatory drug on [K+]e inhomogeneities. [K+]e (expressed as the change in potassium equilibrium potential, dEK [mV]) was measured in 15 preparations using an average of 17 closely spaced, critically calibrated K(+)-sensitive electrodes having stable response characteristics. A series of four 10-minute occlusions each separated by a 50-minute reperfusion period were performed in each study. In half of the studies, intravenous verapamil (0.2 mg/kg bolus followed by 0.0065 mg/kg/hr) was administered before the fourth occlusion. In nine studies (five control and four verapamil), electrodes were placed in the marginal ischemic zone (from 2 mm outside to 5 mm inside the visible cyanotic border). In six other studies (three control and three verapamil), electrodes were placed in the central ischemic zone (10-20 mm within the ischemic region). We determined that the standard deviation is the best measure of inhomogeneity and that 12 equivalent measurement sites are required to estimate it with a satisfactory degree of statistical confidence. We found that after 10 minutes of ischemia, mean dEK was 1.6 times greater in the central than in the marginal ischemic zone, whereas mean standard deviation at the same time was 1.5 times greater in the marginal than in the central ischemic zone. Verapamil reduced mean dEK and mean standard deviation in both ischemic zones for most of the occlusion by delaying the rise in [K+]e and the inhomogeneity of that rise by 3-5 minutes. Comparisons of mean dEK with mean standard deviation revealed a steep linear relation in the marginal zone and a curvilinear relation in the central zone where higher mean dEK values were not accompanied by higher values for mean standard deviation. Furthermore, we determined that these relations were not altered by verapamil.(ABSTRACT TRUNCATED AT 400 WORDS)
Barcelona's asthma epidemics.
Authors: A Judd, J Docherty
Journal: Thorax (1992)

<b>Introduction:</b> Lung transplant (LT) is one of the therapeutic options for patiens with terminal respiratory diseases. It is highly important to incorporate de functional status assessment into the selection process of candidates for lung transplantation, as well as improving rehabilitation program strategies to prevent the risk of frailty during the waiting list. There is evidence that frailty is atributable to advanced organ diseases and that it can be reversed once the function of the organ tat fails is restored. <b>Objective:</b> Identify the incidence of frailty in the LT waiting list for LT. <b>Methodology:</b> Prospective single-center longitudinal study of patients on the waiting list for lung transplant. 74 patients with chronic respiratoriy diseases assessed by the lung transplant committee and accepted to be transplanted in our center. We assessed frailty, muscular dysfunction, functional capacity and lung allocations score (LAS). The results were analyzed with the SPSS statistical package. <b>Results:</b> Sample 48 men and 26 women, with a median agen of 56,55 years (SD 10,87) with LAS average of 35.34 (SD3.8). The incidence of frailty assessed with share-fi is 28,38% and with SPPB 8,1%. As for muscular strength, we obtained the following results: handgrip dynamometry 30.97 Kg, quadriceps dynamometry an average of 17.03 Kg and maximum inspiratory pressure of 65.91%. There is a relationship between the risk of frailty, the meters walked and the maximal inspiratory pressure but not with the LAS. <b>Conclusions:</b> The risk of frailty in patients with terminal chronic respiratory diseases is high, thus it becomes important to conduct a thorough evaluation of frailty in the assessment of lung transplant candidates.
Influence of aortic pressure on effective regurgitant orifice area in aortic regurgitation.
Authors: E S Caguioa, S C Reimold, S Vélez, R T Lee
Journal: Circulation (1992)

BACKGROUND The regurgitant volume in aortic regurgitation is determined by the diastolic filling period, the pressure gradient between the left ventricle and aorta, and the hemodynamic size of the regurgitant orifice area. METHODS AND RESULTS To test the hypothesis that the aortic regurgitant orifice area is related to aortic pressure and aortic root size, 16 fresh calf heart and aorta specimens were studied in vitro using a continuous-flow system over a range of aortic pressures. Regurgitant orifice areas were calculated as the ratio of flow divided by peak velocity through the valve measured by image-guided continuous-wave Doppler, and aortic root areas were measured by two-dimensional echocardiography. When the defect was created at the edge of the noncoronary leaflet (n = 10), regurgitant orifice area gradually increased 51 +/- 33% when aortic pressure was increased from approximately 40 to 152 cm of water (29.6 to 112.5 mm Hg) (p less than 0.0001). Similarly, the aortic root size increased 82 +/- 29% when the defect was created at the leaflet edge (p less than 0.0001). In contrast, when defects were created at the center of the noncoronary leaflet (n = 6), only a small increase in regurgitant orifice area (9 +/- 7%) was observed with increasing pressure (p = 0.043). The aortic root area remained strongly pressure dependent in specimens with defects at leaflet centers (p less than 0.0001). CONCLUSIONS The aortic regurgitant orifice area is dependent on both aortic pressure and the nature of the defect in the valve. Because not all regurgitant aortic valves are alike, further study of the nature of the regurgitant orifice area in humans may allow identification of patients who would benefit most from aggressive pharmacological therapy.
Factors Involved in the Control of Fibroblast Proliferation by Glucocorticoids: A Review
Authors: SYLVIE DURANT, DOMINIQUE DUVAL, FRANÇOISE HOMO-DELARCHE
Journal: Endocrine Reviews (1986)

IT IS well established that glucocorticoids exert catabolic effects on connective tissue and delay wound healing. They induce skin atrophy partly by decreasing the proliferative capacity of skin fibroblasts and the synthesis of the ground substance. Despite extensive investigations, the mechanisms of these in vivo steroid effects remain a matter of controversy, since the studies performed to elucidate the actions of adrenal steroids on the proliferation of various types of fibroblasts in vitro have led to contradictory results. Some authors have indeed described an inhibition of the proliferation of fibroblast cultures treated with glucocorticoids, whereas others have reported a stimulatory action of these drugs on cell division. In the present paper, we have attempted to present a comprehensive review of the data and thus provide an explanation for the differences observed among in vitro experiments. In fact, many of the reported discrepancies may be due, in part, to the use of different experimental models, of different experimental schedules and culture conditions, and to the various methods employed to monitor cell proliferation. Moreover, the complexity of the actions of glucocorticoids in vivo may be explained by the demonstration that, in addition to their metabolic effects on fibroblasts, glucocorticoids also indirectly affect fibroblast proliferation by controlling the syntheses or actions of various factors produced by other cell types.
The Identification of Mild Mitral Regurgitation: Its Separation from Innocent Murmurs by Intracardiac and Esophageal Phonocardiography Combined with Pharmacologic Response.
Authors: Richard F. Leighton
Journal: Annals of Internal Medicine (1964)

s1 October 1964The Identification of Mild Mitral Regurgitation: Its Separation from Innocent Murmurs by Intracardiac and Esophageal Phonocardiography Combined with Pharmacologic Response.Richard F. Leighton, M.D., William L. Page, M.D., Richard S. Goodwin, M.S., Charles F. Wooley, M.D., Joseph M. Ryan, M.D., F.A.C.P.Richard F. Leighton, M.D.Search for more papers by this author, William L. Page, M.D.Search for more papers by this author, Richard S. Goodwin, M.S.Search for more papers by this author, Charles F. Wooley, M.D.Search for more papers by this author, Joseph M. Ryan, M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-61-4-797_1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptNine patients, aged 19 to 48, with apical systolic murmurs, without radiologic or electrocardiographic evidence of cardiac enlargement, were studied. An innocent murmur was frequently suspected. All had external phonocardiograms with pharmacologic studies. Phonocardiograms were also recorded from within the esophagus at the atrial level in eight, and from within the left and right sides of the heart in five and seven patients, respectively. Right heart and pulmonary artery murmurs were thereby excluded and mitral regurgitation was diagnosed in all patients. Confirmation was obtained in three who had left ventricular angiography.These murmurs were of high frequency and either pansystolic... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: Richard F. Leighton, M.D.; William L. Page, M.D.; Richard S. Goodwin, M.S.; Charles F. Wooley, M.D.; Joseph M. Ryan, M.D., F.A.C.P.Affiliations: Columbus, Ohio PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 October 1964Volume 61, Issue 4Page: 797-797KeywordsAngiographyElectrocardiographyEsophagusHeartMitral insufficiencyPatient advocacyPulmonary arteriesSystolic ejection murmur ePublished: 1 December 2008 Issue Published: 1 October 1964 PDF downloadLoading ...
Further experience of reactions, especially of a cerebral nature, in conjunction with triple vaccination: a study based on vaccinations in Sweden 1959-65.
Authors: J Strom
Journal: BMJ (1967)

Tract Infections-Gardner et al. MREDICALJHURNAchildren carries a poor prognosis.Their work thus suggests that repeated direct measurements of arterial blood-gas and pH levels might do much to improve the management of children with severe respiratory tract infections; we would add that repeated electrolyte determinations might also be of value.The use of modern microtechniques greatly reduces the extent to which such investigations disturb a sick child.The mortality rate associated with respiratory tract infections in childhood seems more likely to be reducible by such an approach than by any other at present available to us. SummaryOf 22 children with respiratory tract infections who died in Newcastle and Durham hospitals during a 27-month period, 19 were less than 1 year old.Nine had major con- genital abnormalities.Bacterial infections were apparently responsible for only 6 of the 22 deaths.Respiratory syncytial virus was the only potential pathogen isolated from eight of the children ; it was isolated from necropsy lung specimens in seven of these cases, including all four cases of pneumonia with no apparent bacterial cause ; and it was also isolated from the upper respiratory tract and the lung of a child with haemo- philus epiglottitis.No other viruses were incriminated in any of the 22 cases.Sudden and substantially irreversible collapse was a common feature, especially in the cases not apparently caused by bacteria.Investigation of the blood-gas levels and biochemical changes in such children is suggested as the most promising approach to improved management.
How the Doctors Stand — Grateful Patients
Authors: John Lister
Journal: New England Journal of Medicine (1957)

THE dispute between the doctors and the Government continues to be a matter of the greatest importance, and it has indeed now reached the stage where Sir Russell Brain, P.R.C.P., and Dr. Talbot Rogers, the joint chairmen of the medical profession's negotiating committee, are to have a personal interview with the Prime Minister. This meeting has been precipitated by the repeated refusal of the Minister of Health to examine the claim for a 24 per cent pay increase made by the profession, and the alternative proposal by the Government to set up a Royal Commission to go into the whole . . .
Bevacizumab in Hereditary Hemorrhagic Telangiectasia
Authors: Prithviraj Bose, Jennifer L. Holter, George B. Selby
Journal: New England Journal of Medicine (2009)

To the Editor: Hereditary hemorrhagic telangiectasia (HHT) (also known as the Osler–Weber–Rendu syndrome) is an inherited vascular dysplasia whose main features are mucocutaneous telangiectasias, e...
Desertion, Abandonment, and Neglect of Patient
Authors: David W. Alspaugh
Journal: JAMA (1967)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Schnitzler syndrome: a case report of successful treatment using the anti-CD20 monoclonal antibody rituximab
Authors: K.M. Ramadan, H.A. Eswedi, M.R. El-Agnaf
Journal: British Journal of Dermatology (2007)

Journal Article Schnitzler syndrome: a case report of successful treatment using the anti‐CD20 monoclonal antibody rituximab Get access K.M. Ramadan, K.M. Ramadan Division of Hematology, Leukemia/BMT Program of British Columbia, Vancouver General Hospital and Health Sciences Centre, 10th Floor, Diamond Health Centre, 2775 Laurel Street, Vancouver, BC V5Z 1M9, CanadaDivision of Hematology, Vancouver General Hospital, Vancouver, BC, Canada Search for other works by this author on: Oxford Academic Google Scholar H.A. Eswedi, H.A. Eswedi Department of Haematology, Ulster Hospital, Belfast, U.K. E‐mail: kramadan4@doctors.org.uk Search for other works by this author on: Oxford Academic Google Scholar M.R. El‐Agnaf M.R. El‐Agnaf Department of Haematology, Ulster Hospital, Belfast, U.K. E‐mail: kramadan4@doctors.org.uk Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 156, Issue 5, 1 May 2007, Pages 1072–1074, https://doi.org/10.1111/j.1365-2133.2007.07799.x Published: 01 May 2007
Physician Acquiescence to Patient Demands for Brand-Name Drugs: Results of a National Survey of Physicians
Authors: Eric G. Campbell, Genevieve Pham-Kanter, Christine Vogeli, Lisa I. Iezzoni
Journal: JAMA Internal Medicine (2013)

Systems-Level Interventions to Improve Value in Prescription Medication Use: Comment on “Physician Acquiescence to Patient Demands for Brand-Name Drugs”
Indomethacin-induced scar thinning after experimental myocardial infarction.
Authors: H Hammerman, R A Kloner, F J Schoen, E J Brown, S Hale, E Braunwald
Journal: Circulation (1983)

We investigated the effect of indomethacin, a widely used nonsteroidal antiinflammatory drug, on the healing of myocardial infarction (MI). Experimental MI was produced in anesthetized, open-chest dogs by occluding the left anterior descending coronary artery. Ten dogs received indomethacin, 10 mg/kg i.v., and 11 received saline, 15 minutes and 3 hours after occlusion. After 6 weeks, the dogs were killed and their hearts were subjected to morphologic and biochemical analysis. The average thickness of the transmural scar and the noninfarcted left ventricular wall was measured at multiple sites in formalin-fixed left ventricular slices and the ratio of the thickness of the transmural scar to the noninfarcted wall determined. The average thickness of the noninfarcted wall was 8.80 +/- 0.19 mm (mean +/- SEM) in the control group and 8.44 +/- 0.26 mm in the indomethacin group (NS). The scar thickness was 7.24 +/- 0.64 mm in the control group and 3.56 +/- 0.40 mm in the indomethacin group (p less than 0.001). The ratio of scar to noninfarcted wall thickness was 0.83 +/- 0.07 in the control group and 0.43 +/- 0.04 in the indomethacin group (p less than 0.001). Scars in treated dogs did not differ from controls either by light microscopic histologic analysis or by analysis of hydroxyproline content per unit weight. We conclude that indomethacin results in marked scar thinning when given early after experimental MI.