THE TREATMENT OF RHEUMATOID ARTHRITIS WITH HEXAMETHONIUM CHLORIDE: A PRELIMINARY REPORT
Authors: W D PLATT, I H STEINBERG
Journal: Annals of Internal Medicine (1955)

Article1 April 1955THE TREATMENT OF RHEUMATOID ARTHRITIS WITH HEXAMETHONIUM CHLORIDE: A PRELIMINARY REPORTWARREN D. PLATT JR., M.D., IRVING H. STEINBERG, M.D.WARREN D. PLATT JR., M.D.Search for more papers by this author, IRVING H. STEINBERG, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-42-4-816 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptAn approach to the therapy of rheumatoid arthritis through treatment of the associated vascular disturbance has been used by many investigators, with inconsistent results. In 1930 a most direct and apparently successful approach was used by Rowntree et al.1in the performance of lumbar and cervicothoracic sympathectomies in 17 patients with rheumatoid arthritis. The rationale for such treatment lay in the frequently noted vegetative disturbances of abnormal sweating, cyanosis, coldness and tingling in the extremities of patients suffering from rheumatoid arthritis. The results of sympathectomy indicated that there was marked relief of periarticular pain in 12 of the 17 patients...Bibliography1. RowntreeAdsonHench LGAWPS: Preliminary results of resection of sympathetic ganglia, Ann. Int. Med. 4: 447, 1930. LinkGoogle Scholar2. Sundelin F: Investigations of cerebrospinal fluid in cases of rheumatoid arthritis, Am. J. Med. 2: 579, 1947. CrossrefMedlineGoogle Scholar3. Boucek R: A vascular approach to the treatment of rheumatoid arthritis, Am. J. M. Sc. 215: 198, 1948. CrossrefMedlineGoogle Scholar4. NaideSayenComroe MABI: Characteristic vascular pattern in patients with rheumatoid arthritis, Arch. Int. Med. 76: 139, 1945. CrossrefGoogle Scholar5. KovecsWrightDuryee JISAW: The surface temperature and the minute blood vessels of the skin in arthritis, J. A. M. A. 100: 1018, 1933. CrossrefGoogle Scholar6. HenchKovecsWright PSJIS: American Association for the Study of Control of Rheumatoid Diseases (Society Proceedings), J. A. M. A. 103: 1804, 1934. Google Scholar7. WoodmanseyCollinsErnst DHDHMM: Vascular reactions to the bath in health, Lancet 2: 1350, 1938. CrossrefGoogle Scholar8. Traeger CH: Use of vitamins in treatment of chronic arthritis, M. Clin. North America 30: 616, 1946. CrossrefGoogle Scholar9. CoplanMargolis PSHM: Reflex sympathetic dystrophy, Am. Pract. 2: 814, 1948. Google Scholar10. Freis ED: Clinical evaluation of hexamethonium, a new ganglionic blocking agent, preliminary report, Am. J. Med. 11: 242, 1951. CrossrefGoogle Scholar11. RobinsonBolandBunimCrainEnglemanGrahamLockieMontgomeryRaganRopesRosenbergSmyth WDEWJJDCEPWLMMMCMWEFCJ: Rheumatism and arthritis: review of American and English literature of recent years (Tenth Rheumatism Review), Part II, Ann. Int. Med. 39: 757-906, 1953. AbstractGoogle Scholar12. Howell TH: Relief of pain in rheumatoid arthritis with tetraethylammonium bromide, Lancet 1: 204, 1950. CrossrefMedlineGoogle Scholar13. KlaymanSilbergKarlen MINRWS: Death associated with hexamethonium and 1-hydrazinophthalazine (Apresoline) therapy, New England J. Med. 248: 1109, 1953. CrossrefMedlineGoogle Scholar14. RobinsonBolandBunimCrainEnglemanGrahamLockieMontgomeryRaganRopesRosenbergSmyth WDEWJJDCEPWLMMMCMWEFCJ: Rheumatism and arthritis: review of American and English literature of recent years (Tenth Rheumatism Review), Part I, Ann. Int. Med. 39: 498-618, 1953. AbstractGoogle Scholar15. Schroeder HW: Control of hypertension by hexamethonium and 1-hydrazinophthalazine, Arch. Int. Med. 89: 523, 1952. CrossrefGoogle Scholar16. FinnertyFreis FED: Experimental and clinical studies with hexamethonium chloride, Am. J. Med. 10: 233, 1951. CrossrefGoogle Scholar17. SteinbrockerSpitzerFriedman ONHH: The shoulder-hand syndrome in reflex dystrophy of the upper extremity, Ann. Int. Med. 29: 22, 1948. LinkGoogle Scholar18. KellgrenSamuel JHEP: The sensitivity and innervation of the articular capsule, J. Bone and Joint Surg. 32-B: 84, 1950. CrossrefGoogle Scholar19. TurnerLansbury WJ: Low diastolic pressure as a clinical feature of rheumatoid arthritis and its possible etiologic significance, Am. J. M. Sc. 227: 503, 1954. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Springfield, Massachusetts*Received for publication June 14, 1954. Presented before the New England Rheumatism Society, Annual Meeting, May 21, 1954.From the Arthritis Clinic, Department of Medicine, The Springfield Hospital, Springfield, Massachusetts. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byRHEUMATISM AND ARTHRITIS: REVIEW OF AMERICAN AND ENGLISH LITERATURE OF RECENT YEARS (TWELFTH RHEUMATISM REVIEW)* Part IICHARLEY J. SMYTH, M.D., F.A.C.P., JOSEPH J. BUNIM, M.D., F.A.C.P., WILLIAM S. CLARK, M.D., F.A.C.P., DARRELL C. CRAIN, M.D., F.A.C.P., FELIX E. DEMARTINI, M.D., IVAN F. DUFF, M.D., F.A.C.P., EPHRAIM P. ENGLEMAN, M.D., F.A.C.P., DONALD C. GRAHAM, M.D., F.R.C.P. (C), MAX M. MONTGOMERY, M.D., F.A.C.P., BERNARD M. NORCROSS, M.D., F.A.C.P., HOWARD F. POLLEY, MARIAN W. ROPES, M.D., F.A.C.P., EDWARD F. ROSENBERG, M.D., F.A.C.P.EXTENDED SYMPATHECTOMY IN THE TREATMENT OF CHRONIC ARTHRITISEffect of the Ganglion Blocking Drug Pendiomide on the Symptoms of Rheumatoid Arthritis 1 April 1955Volume 42, Issue 4Page: 816-825KeywordsArthritisChloridesHospital medicineRheumatoid arthritisSympathectomy Issue Published: 1 April 1955 PDF downloadLoading ...