APLASTIC ANEMIA: AN ANALYSIS OF 50 CASES
Authors: D N MOHLER, B S LEAVELL
Journal: Annals of Internal Medicine (1958)

Article1 August 1958APLASTIC ANEMIA: AN ANALYSIS OF 50 CASESDANIEL N. MOHLER, M.D., BYRD S. LEAVELL, M.D., F.A.C.P.DANIEL N. MOHLER, M.D.Search for more papers by this author, BYRD S. LEAVELL, M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-49-2-326 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptINTRODUCTIONSince Ehrlich's1 original description of aplastic anemia in 1888, many names have been applied to this type of anemia: bone marrow failure,2 aleukia hemorrhagica,3 aregenerative anemia,3 panmyelophthisis,3 marrow insufficiency,4 toxic paralytic anemia,5 progressive hypocythemia,6 hypoplastic anemia,7 refractory anemia8 and adynamic anemia.9 The Committee for Clarification of the Nomenclature of Cells and Diseases of the Blood and Blood-forming Organs10 has recommended the term "hypoplastic normocytic or macrocytic anemia, due to unknown cause."None of the suggested names is entirely satisfactory. The chief objection to the term "aplastic anemia" is the fact, first pointed out by Blumer11in 1905 and later...Bibliography1. Ehrlich P: Über einen Fall von Anämie, mit Bemerkungen über regenerative Veranderungen des Knochenmarks, Charité-Ann. 13: 300, 1888. Google Scholar2. VaquezAubertin MMC: L'anémie pernicieuse d'apres les conceptions actuelles, Bull. et mém. Soc. méd. d. hôp. de Paris 21: 288, 1904. Google Scholar3. Frank E: Aleukia hemorrhagica. Aplastische (aregenerative) Anämie-panmyelophthise, Berl. klin. Wchnschr. 52: 961, 1915. Google Scholar4. Minot GR: Diminished blood platelets and marrow insufficiency, Arch. Int. Med. 19: 1062, 1917. CrossrefGoogle Scholar5. Schneider JP: Aplastic anemia, Am. J. M. Sc. 156: 799, 1918. CrossrefGoogle Scholar6. ThompsonRichterEdsall WPMNKS: Analysis of so-called aplastic anemia, Am. J. M. Sc. 187: 77, 1934. CrossrefGoogle Scholar7. DiamondBlackfan LKKD: Hypoplastic anemia, Am. J. Dis. Child. 56: 464, 1938. Google Scholar8. 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Author, Article, and Disclosure InformationAffiliations: Charlottesville, Virginia*Received for publication July 29, 1957.From the Department of Internal Medicine, University of Virginia School of Medicine, Charlottesville, Virginia.†Trainee, National Cancer Institute.Requests for reprints should be addressed to Byrd S. Leavell, M.D., Department of Internal Medicine, University of Virginia School of Medicine, Charlottesville, Virginia. 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