tbuckley/cabot-search huggingface dataset:
Delivery of tumor-homing TRAIL sensitizer with long-acting TRAIL as a therapy for TRAIL-resistant tumors
Authors: Yumin Oh, Magdalena Swierczewska, Tae Hyung Kim, Sung Mook Lim, Ha Na Eom, Jae Hyung Park, Dong Hee Na, Kwangmeyung Kim, Kang Choon Lee, Martin G. Pomper, Seulki Lee
Journal: Journal of Controlled Release (2015)
Abstract 18122: Reduction of Scar Tissue after GHRH-Agonist Treatment in a Swine Model of Sub-acute Ischemic Cardiomyopathy
Authors: Luiza Lima Bagno, Rosemeire Kanashiro-Takeuchi, Viky Suncion, Samuel Golpanian, Vasileios Karantalis, Ariel Wolf, Bo Wang, Courtney Premer, Wayne Balkan, Jose Rodriguez, David Valdes, Marcos Rosado, Norman Block, Peter Goldstein, Azorides Morales, Andrew Schally, Joshua M Hare
Journal: Circulation (2014)

Introduction: Growth hormone-releasing hormone receptor agonists (GHRH-A) stimulate cardiac repair following myocardial infarction (MI) in rats through the activation of the GHRH signaling pathway within the heart. Hypothesis: We tested the hypothesis that the administration of GHRH-A prevents ventricular remodeling in a swine sub-acute MI model. Methods: Twelve female Yorkshire swine (25-30 Kg) underwent transient occlusion of the LAD coronary artery (MI). Two-weeks post-MI, swine were randomized to receive injections of either 30 μg/Kg GHRH-A (MR-409) (GHRH-A group; n=6) or vehicle (placebo group; n=6). Cardiac MRI, pressure volume loops and measures of endothelial function were obtained at multiple time points. Infarct-, border- and remote- (non-infarcted) zones were assessed for growth hormone-releasing hormone receptor (GHRHR) by immunohistochemistry. Results: Four-weeks of GHRH-A treatment resulted in reduced scar mass (GHRH-A: –21.9±6.42%; p=0.02; placebo: 10.9±5.88%; p=0.25; Two-way ANOVA; p=0.003...
Care programme approach does not focus on need for services
Authors: E. Salib, A. Joseph
Journal: BMJ (1996)

Year of surveyFig 1-Decrease in blood lead concentrations in groups at risk of increased lead uptake from traffic emissions and in control subjects living in areas with- out heavy traffic and in general population, United Kingdom, 1984-96 sure of the general population to lead from traffic emissions would have been intermediate between that of the exposed and control groups.Figure 1 shows that, since 1984-7, blood lead concentra- tions have fallen by a factor of 2.6-3.0 in adults and by a factor of 3.6-5.0 in children.A wide range of measures to reduce lead were implemented in Britain throughout the 1980s- for example, lead solder was removed from tins containing food, lead in paint was controlled, and lead in petrol was reduced.All of these, together with the reduced emissions of lead by vehicles owing to the increased sales of lead free petrol since 1987,' will have contributed to the substantial decline in blood lead concentrations that we observed.
Abstract LB-186: Fiber intake modulates the effect of alcohol on breast cancer
Authors: Isabelle Romieu
Journal: Cancer Research (2015)

Abstract Alcohol intake has been related to an increase risk of breast cancer while dietary fiber intake has been inversely correlated to breast cancer risk. A beneficial effect of fiber on ethanol carcinogenesis through their impact on estrogen levels is still controversial. The purpose of this study is to investigate the role of dietary fiber as potential modifying factors of the association of alcohol to breast cancer using data from the European Prospective Investigation into Cancer and Nutrition (EPIC) study. A prospective observational study of 334,850 women aged 35-70 years at baseline enrolled in the ten countries of the EPIC study and followed up for 11.0 years on average was conducted. Information on fiber and alcohol intake at baseline and average lifetime alcohol intake were calculated from country-specific dietary and lifestyle questionnaires. Hazard ratios (HR) and 95% confidence intervals (CI) of developing invasive breast cancer according to different levels of alcohol and fiber intake were calculated. During 3,670,439 person-years, 11,576 incident breast cancer cases were diagnosed. Among women with low intake of fiber (&amp;lt;18.5 g/day), the risk of breast cancer per 10g/day of alcohol intake was 1.057 (1.032;1.082) while among women with high intake of fiber (&amp;gt;24.2 g/day) the risk of breast cancer was 1.012 (0.983;0.1.04) (Test for interaction p = 0.01). This modulating effect was stronger for fiber from vegetables and for estrogen positive tumors. Our results suggest that fiber intake may modulate the positive association of alcohol intake to breast cancer risk. Women should be advised to control their alcohol intake, and increase their intake of fiber. Citation Format: Isabelle Romieu. Fiber intake modulates the effect of alcohol on breast cancer. [abstract]. In: Proceedings of the 106th Annual Meeting of the American Association for Cancer Research; 2015 Apr 18-22; Philadelphia, PA. Philadelphia (PA): AACR; Cancer Res 2015;75(15 Suppl):Abstract nr LB-186. doi:10.1158/1538-7445.AM2015-LB-186
Mental illness and creative activity in female writers
Authors: A M Ludwig
Journal: American Journal of Psychiatry (1994)

This study addressed three questions. Are female writers more likely to suffer from mental illness than members of a matched comparison group? If so, does a familial basis exist for their psychopathology and creativity? What factors predict overall creativity in women?Questionnaire and interview data were obtained on 59 female writers and 59 members of a matched comparison group. These data were used to assess overall creativity and to identify psychiatric disorders in subjects and their first-degree relatives.Female writers were more likely than members of the comparison group to suffer not only from mood disorders but from drug abuse, panic attacks, general anxiety, and eating disorders as well. The rates of multiple mental disorders were also higher among writers. Although there was evidence for the familial transmission of psychopathology, physical or sexual abuse during childhood also loomed as a potential contributor to later psychological difficulties. Creativity also appeared to run in families. The cumulative psychopathology scores of subjects, their reported exposure to sexual or physical abuse during childhood, mental difficulties in their mothers, and the combined creativity scores of their parents represented significant predictors of their overall creativity.The high rates of certain emotional disorders in female writers suggested a direct relationship between creativity and psychopathology. But the relationship was not necessarily a simple one. As the results of the predictive analysis indicated, familial and environmental factors also appeared to play an important role.
Different Cell Types Within the Sinoatrial Node
Authors: Luiz A. Benvenuti, Vera D. Aiello, Maria de L. Higuchi
Journal: Circulation (1999)

In a recent interesting article, 1 Zhang and Hintze stated that amlodipine but not nifedipine released nitric oxide from canine coronary microvessels and classified this as an unexpected mechanism of action.However, it should be noted that several years ago, the same phenomenon, ie, direct release of NO, was observed with nitrendipine in small porcine coronary arteries, porcine arteria basilaris, and porcine arteria caudalis. 2Similarly, the vasodilating action of nitrendipine, nifedipine, nisoldipine, and nimodipine in guinea pig mesenteric vascular beds was found to be sensitive to L-N G -nitroarginine treatment. 3 The latter was more pronounced in smaller arterioles (diameter Ͻ350 m).Regarding the mechanism of action underlying the release of NO, it was shown recently by use of the fura-2 technique that the calcium antagonist nitrendipine enhances the intracellular calcium concentration in suspensions of cultured endothelial cells. 4 This effect was insensitive to thapsigargin but was sensitive to extracellular depletion of calcium, indicating that the observed increase in intracellular calcium concentration was mainly due to an influx of calcium rather than a calcium release from intracellular stores.The elevation of intracellular calcium by nitrendipine could be completely blocked by application of gadolinium, a trivalent lanthanide known to inhibit shear stress-activated cation-selective channels on endothelial cells.In addition, the authors showed that the increase in intracellular [Ca 2ϩ ] by shear stress was further enhanced in the presence of nitrendipine. 4 In summary, the release of NO from vascular endothelium is not unique to amlodipine but seems to be a group phenomenon of 1,4-dihydropyridines.The NO release may be more or less prominent when various substances in various vessel types are compared.As shown, the NO dependence of vasodilation by 1,4-dihydropyridines may also be influenced by the position of the vessels within the vascular tree. 3 In addition, this NOreleasing action is not restricted to vascular endothelium but can also be found in platelets, as shown for nifedipine, and contributes to its antiaggregatory effects.
Abstract 53: Decoding Twitter: What Does the Public Want to Know About Cardiac Arrest and Resuscitation?
Authors: Nina W Zhao, Justin C Bosley, Lance Becker, David A Asch, Raina M Merchant
Journal: Circulation (2011)

Background: Social media sites like Twitter are growing in popularity and offer new avenues to share and seek health information. Twitter may also serve as an important public health tool for experts to widely disseminate accurate information about cardiovascular health. The manner and extent of the public's information-seeking behavior however is unknown. To better understand public inquiries about resuscitation, we sought to characterize tweets with questions about cardiac arrest, CPR, and AEDs. Methods: A database of 53,971 tweets relating to resuscitation was created using a Twitter search engine for daily tweet downloads from April 19-May 22, 2011. Search terms were: AED, cardiac arrest, CPR, defibrillation, heart arrest, and resuscitation. Tweets containing nonsensical, non-English, non-sequitur, or irrelevant information were excluded (n=39,990). Remaining tweets were individually evaluated for information seeking questions. Results: Of 13,981 tweets with resuscitation-relevant content, 1% (162) had questions related to cardiac arrest/CPR/AED. Inquires were distributed across the study time period with a mean 4.8 questions daily. Several tweets, 21% (34/162) were cardiac arrest-related queries related to: symptoms, risk factors, prognosis, distinction from heart attack, treatment options, utility of abdominal compressions, and therapeutic hypothermia indications. Several tweets, 39% (63/162) were CPR-specific queries related to: definitions, guidelines, technique, certification classes (location, duration, and professional requirements), neonatal resuscitation, hyperventilation treatment, and accuracy of media portrayal of resuscitation. Additionally, 40% (65/162) of tweets were AED-specific queries related to: device safety, cost, purchasing advice, availability, proper use, effectiveness, and batteries. Conclusion: Twitter offers a novel venue for the public to ask questions regarding cardiovascular health. While few tweets were true information-seeking messages, they represent unique opportunities for expert intervention, education, and awareness. Future work in this field may aim to uncover how receptive users are to professional answers and healthcare education delivered via tweets.
Abstract #244: A Standardized CAIX immunohistochemistry test for use in formalin-fixed, paraffin-embedded (FF-PE) sections
Authors: Peter Hamer, Sheryl Brown-Shimer, Walter Carney
Journal: Cancer Research (2009)

Introduction:  Carbonic anhydrase isoform IX (CA IX) is a mammalian enzyme that assists in the inter-conversion of carbon dioxide and water into carbonic acid, protons, and bicarbonate ions to maintain acid-base balance in blood and tissues. Carbonic anhydrase IX has become an important marker for various cancers and is over-expressed in many cancers. Its expression is strongly induced by hypoxia and correlates with a poor response to classical therapies and is associated with increased metastasis and poor prognosis. By tissue analysis, CAIX has been found to be overexpressed in a high percentage of clear cell renal cell carcinomas (RCC). There are many reports of CAIX expression by immunohistochemistry (IHC) in the literature, but an assortment of antibodies are used, along with different antigen retrieval systems and procedures, leading to a lack of standardization.  Materials and Methods:  We have developed a standardized IHC test using the M75 monoclonal antibody (mab) that detects CAIX in formalin-fixed paraffin-embedded (FF-PE) tissues. This Research Use Only (RUO) test works without the use of any type of antigen retrieval. The scoring system is based on the percentage of cells that are positive for CAIX staining as well as the intensity of that staining. In addition, only membrane staining of CAIX is considered positive.  Results:  We have analyzed a number of normal and cancer tissues using both tissues and tissue microarrays (TMA). Data with normal tissues showed that 100% of stomach and 12% of colon are positive for CAIX staining. In addition, when examining tumor tissues, we found that >90% of colon and esophageal tumors were positive for CAIX staining.$$table_{02631489-AA06-4AC6-88C3-735E3C033589}$$  Conclusions:  This study describes the first standardized IHC kit utilizing the M75 mab for detection of CAIX in FF-PE tissue sections. It is anticipated that the availability of this test will assist in the detection of CAIX positive tumors and perhaps aid in the development of anti-angiogenic or anti-hypoxic cancer therapies.   Citation Information:  In: Proc Am Assoc Cancer Res; 2009 Apr 18-22; Denver, CO. Philadelphia (PA): AACR; 2009. Abstract nr 244.
Thrombocyte HLA molecules retain nonrenewable endogenous peptides of megakaryocyte lineage and do not stimulate direct allocytotoxicity in vitro
Authors: Cécile Gouttefangeas, Marianne Diehl, Wieland Keilholz, Rainer Frank Hörnlein, Stefan Stevanović, Hans-Georg Rammensee
Journal: Blood (2000)
Intraperitoneal yttrium-90-labeled monoclonal antibody in ovarian cancer.
Authors: J S Stewart, V Hird, D Snook, B Dhokia, G Sivolapenko, G Hooker, J T Papadimitriou, G Rowlinson, M Sullivan, H E Lambert
Journal: Journal of Clinical Oncology (1990)

From March 1987 to March 1988, a phase I to II study was carried out in 25 patients with ovarian cancer. They received escalating doses of intraperitoneally (IP) administered yttrium-90 (Y-90)-labeled monoclonal antibody, HMFG1, against a tumor cell-surface antigen. Myelosuppression prevented an escalation of the administered Y-90 activity above 25 mCi. Y-90-labeled antibody was absorbed from the peritoneal cavity into the circulation. Maximum blood Y-90 activity was observed 40 hours after the IP injection with a mean of 21% of the injected activity (range, 14.2% to 26.4%) in the circulation. The radiation dose the bone marrow received from circulating Y-90-labeled antibody (the blood radiation dose) was calculated by applying the Medical Internal Radiation Dose (MIRD) formulation to the measured Y-90 activity in patients blood. Myelosuppression occurred following calculated blood radiation doses to bone marrow of only 10 to 30 cGy. The excessive myelosuppression following such modest radiation doses from circulating Y-90-labeled antibody could be explained by the uptake of Y-90 by bone. In an attempt to reduce bone absorption of Y-90, seven patients received an intravenous (IV) infusion of EDTA (Sinclair Pharmaceuticals Ltd, Godalming, United Kingdom). This increased the urinary excretion of Y-90 from a mean of 11.1% to 32.3% of the injected activity (P = .0001). Fourteen patients had assessable tumor at laparoscopy. Tumor regression was observed in one patient, and palliation of ascites in a further patient.
RHEUMATIC HEART DISEASE IN PHILADELPHIA SCHOOL CHILDREN
Authors: Jacob M. Cahan
Journal: Annals of Internal Medicine (1937)

Article1 June 1937RHEUMATIC HEART DISEASE IN PHILADELPHIA SCHOOL CHILDRENJACOB M. CAHAN, M.D., F.A.C.P.JACOB M. CAHAN, M.D., F.A.C.P.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-10-12-1752 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptAbout 1 per cent of the 350,000 children in the public and parochial schools of Philadelphia†have some form of heart disease. The main causes of heart affection, as is well known, are congenital developmental defects, rheumatic fever and other infections, syphilis and degenerative changes. Of these causes, congenital defects and rheumatic infection, chiefly, pertain to children of school age, and rheumatic heart disease by itself constitutes by far the most frequent variety. The common age at the onset of rheumatic infection coincides with the years of the child's school attendance, namely, from five to eighteen. In fact, the child...Reference1. CAHAN JM: The incidence of heart disease in school children, Jr. Am. Med. Assoc., 1929, xcii, 1576. CrossrefGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Philadelphia, Pennsylvania*Received for publication August 12, 1936.†Philadelphia, Pennsylvania, is a city of over two million inhabitants, and has a temperate climate. North Philadelphia, the section in which the survey has been conducted is inhabited largely by families whose social condition is a little better than the average, although about one-fifth of them are poor.‡A blank form will be furnished with the reprint, on request PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byDetection of Heart Disease in Children 1919-1967Use of Tape-Recorded Heart Sounds in Screening of Children for Heart DiseaseThe changing pattern of rheumatic heart diseaseExperience in secondary screening of cardiac suspects of school ageThe incidence of rheumatic heart disease in native school children of Dade County, FloridaHeart disease in San Francisco school childrenHeart disease in children in a rural iowa county—particularlyin relation to rheumatic feverIncidence of heart disease and rheumatic fever in school children in three climatically different california communitiesThe incidence of organic heart disease in school childrenIncidence and type of heart disease in San Francisco school children 1 June 1937Volume 10, Issue 12Page: 1752-1765KeywordsCardiovascular therapyChildrenCongenital disordersCongenital heart defectsEmotionsInfectious diseasesPediatric infectionsRheumatic feverSyphilis ePublished: 1 December 2008 Issue Published: 1 June 1937 PDF downloadLoading ...
Abstract 2760: Termination or Persistence of Atrial Fibrillation during Left Atrial Substrate Modification Does Not Correlate with Long-Term Clinical Outcome in Longstanding, Persistent Atrial Fibrillation
Authors: Kiyoshi Otomo, Yasutoshi Nagata, Hiroshi Tachiguchi, Kikuya Uno, Hideomi Fujiwara, Yoshito Iesaka
Journal: Circulation (2008)

It was recently reported that the abolition of atrial fibrillation (AF) during the left atrial (LA) ablation targeting AF maintenance substrates (LA-Ab) correlated with better clinical outcome in longstanding, persistent AF (LP-AF). This study was aimed to test if the AF termination or conversion to atrial tachycardia (AT) during LA-Ab was related to better subsequent clinical outcome in LP-AF. This study included 94 consecutive patients (pts) with drug-refractory, LP-AF (age: 62+/−9 years, AF duration: 80+/−76 months, LA diameter: 48+/−5 mm) who underwent the initial LA-Ab combined with extensive encircling PV isolation (EEPVI). After completion of EEPVI, the LA-Ab targeting the continuous, fractionated atrial electrograms was performed sequentially at the roof, inferoposterior region, septum, mitral annulus along the coronary sinus, mitral isthmus and base of LA appendage during sustained AF until AF terminated. The results of the initial session and follow-up data after the initial session were reviewed. Of the 94 pts, conversion of AF to AT (n=35) and/or AF/AT termination (n=34) were observed in 52 pts (55%: Group-1). In the remaining 42 pts (45%: Group-2), neither AF termination nor conversion to AT was observed during the LA-Ab. During the early phase (&lt;1 month) of the follow-up, 40 pts (43%) had acute recurrences of AF (n=16) or AT (n=24) 8+/−9 days after the LA-Ab session, and its incidence was significantly lower in Group-1 than in Group-2 (15/52 (29%) vs 25/42 (61%); P=0.003). During the later phase (=/&gt;1 month; average=257+/−130 days), 73 (78%) of the 94 pts were free from AF/AT episodes with antiarrhythmic medications in 40 pts (43%), while the remaining 21 pts (22%) had recurrence of AF (n=9) or AT (n=12). The AF/AT-free rate during the later phase of the follow-up was not significantly different between the groups (Group-1 vs Group-2: 41/52 pts (79%) vs 30/42 pts (76%); P=0.25). Although the termination of AF/AT or conversion of AF to AT during LA-Ab correlated with better clinical outcome in the early phase, it did not correlate with subsequent freedom from AF/AT in LP-AF. The termination of AF/AT or conversion of AF to AT might not be an optimal procedural endpoint during the LA-Ab.
High-Resolution Array-Based Comparative Genome Hybridization (CGH) Identifies Novel and Recurrent Regions in CLL.
Authors: Vladimir Grubor, Alex Krasnitz, Jennifer E. Troge, Jennifer L. Meth, B. Lakshmi, Jude T. Kendall, Boris Yamrom, Garrick Alex, Deepa Pai, Nicholas Navin, Lisa A. Hufnagel, Yoon-ha Lee, Kerry Cook, Steven L. Allen, Kanti R. Rai, Rajendra Damle, Carlo Calissano, Nicholas Chiorazzi, Michael H Wigler, Diane Esposito
Journal: Blood (2008)
Aortic Regurgitation
Authors: Maurice Enriquez-Sarano, A. Jamil Tajik
Journal: New England Journal of Medicine (2004)

A 48-year-old woman who reports mild fatigue but no dyspnea, chest pain, or palpitation is found to have a diastolic murmur. Doppler color-flow echocardiography shows a bicuspid aortic valve with an eccentric jet of aortic regurgitation by color-flow imaging. The left ventricle is moderately enlarged, with an end-diastolic diameter of 66 mm (or 39 mm per square meter of body-surface area) and an end-systolic diameter of 46 mm (or 27 mm per square meter); the ejection fraction is 51 percent, and the ascending aorta is enlarged, at 48 mm. How should this patient be treated?