PRELIMINARY OBSERVATIONS ON THE TREATMENT OF POSTIRRADIATION HEMATOPOIETIC DEPRESSION IN MAN BY THE INFUSION OF STORED AUTOGENOUS BONE MARROW
Authors: N B KURNICK, A MONTANO, J C GERDES, B H FEDER
Journal: Annals of Internal Medicine (1958)

Article1 November 1958PRELIMINARY OBSERVATIONS ON THE TREATMENT OF POSTIRRADIATION HEMATOPOIETIC DEPRESSION IN MAN BY THE INFUSION OF STORED AUTOGENOUS BONE MARROWN. B. KURNICK, M.D., F.A.C.P., ANDREW MONTANO, B.S., JAMES C. GERDES, M.D., BERNARD H. FEDER, M.D.N. B. KURNICK, M.D., F.A.C.P., ANDREW MONTANO, B.S., JAMES C. GERDES, M.D., BERNARD H. FEDER, M.D.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-49-5-973 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptINTRODUCTIONThe work of Lorenz et al.1on the protection of rodents against lethal x-radiation by the subsequent intravenous injection of bone marrow has been amply confirmed.2Recent studies have demonstrated that the injected bone marrow cells repopulate the depleted bone marrow of the recipient.3, 4, 5, 6Barnes and Loutit7have demonstrated that the radiation-protective bone marrow elements can be preserved for at least 83 days by freezing in glycerol and storing in the cold. These authors have further reported the treatment of murine leukemia by lethal total-body irradiation, followed by homologous bone marrow injection.8On the basis of...Bibliography1. LorenzUphoffReidShelton EDTRE: Modification of irradiation injury in mice and guinea pigs by bone marrow injection, J. Nat. Cancer Inst. 12: 197-201, 1951. MedlineGoogle Scholar2. Congdon CC: Experimental treatment of total body irradiation injury: a brief review, Blood 12: 746, 1957. CrossrefMedlineGoogle Scholar3. FordHamertonBarnesLoutit CEJLDWJF: Cytological identification of radiation-chimaeras, Nature, London 177: 452, 1956. CrossrefMedlineGoogle Scholar4. LindsleyOdelTausche DLTTFG: Implantation of functional erythropoietic elements following total body irradiation, Proc. Soc. Exper. Biol. and Med. 90: 512, 1955. CrossrefMedlineGoogle Scholar5. NowellColeHabermeyerRoan PCLJJGPL: Growth and continued function of rat marrow cells in x-radiated mice, Cancer Research 16: 258, 1956. MedlineGoogle Scholar6. VosDavidsWeyzenVan Bekkum OJAWWDW: Evidence for the cellular hypothesis in radiation protection by bone marrow cells, Acta Physiol. Pharmacol. Neerl. 4: 482, 1956. MedlineGoogle Scholar7. BarnesLoutit DWJF: The radiation recovery factor: preservation by the Polge-Smith-Parkes technique, J. Nat. Cancer Inst. 15: 901-905, 1955. MedlineGoogle Scholar8. BarnesCorpLoutitNeil DWMFJFFE: Treatment of murine leukemia with x-rays and homologous bone marrow, Brit. M. J. 2: 626, 1956. CrossrefMedlineGoogle Scholar9. ThomasLochteLuFerrebee EDHLWCJW *: Intravenous infusion of bone marrow in patients receiving radiation and chemotherapy, New England J. Med. 257: 491-496, 1957. CrossrefMedlineGoogle Scholar10. BarnesLoutit DWJF: Treatment of murine leukemia with x-rays and homologous bone marrow, Brit. J. Haematol. 3: 241-252, 1957. CrossrefMedlineGoogle Scholar11. Van BekkumVos DWO: Immunological aspects of homo- and heterologous bone marrow transplantation in irradiated animals, J. Cell, and Comp. Physiol. 50: 139-156, 1957. CrossrefGoogle Scholar12. Makinodan T: Immunology of bone marrow transplantation, J. Cell. and Comp. Physiol. 50: 327-351, 1957. CrossrefGoogle Scholar13. BiermanKelly HRKH: Multiple marrow aspiration in man from posterior ilium, Blood 11: 370-374, 1956. CrossrefMedlineGoogle Scholar14. Schrek R: A method for counting the viable cells in normal and malignant cell suspensions, Am. J. Cancer 28: 389-392, 1936. Google Scholar15. Sloviter HA: Method for preparing thawed erythrocyte glycerol mixtures for transfusion, Am. J. M. Sc. 231: 437-440, 1956. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Long Beach, California*Presented at the Thirty-ninth Annual Session of The American College of Physicians, Atlantic City, New Jersey, May 1, 1958.From the Long Beach Veterans Administration Hospital and the Department of Medicine, University of California Medical Center, Los Angeles, California.†This study was supported in part by grants-in-aid from the National Institutes of Health, U. S. Public Health Service, and the American Cancer Society.Requests for reprints should be addressed to N. B. Kurnick, M.D., Medical Research (R-2), Veterans Administration Hospital, Long Beach 4, California. 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B. KURNICK, M.D., F.A.C.P., BERNARD H. FEDER, M.D., ANDREW MONTANO, B.S., JAMES C. GERDES, M.D., ROBERT NAKAMURA, M.D.Technics of Human-Bone-Marrow Procurement by Aspiration from Living DonorsTransplantation of tissuesDISSEMINATED MALIGNANT MELANOMATreatment of Terminal Leukemic Relapse by Total-Body Irradiation and Intravenous Infusion of Stored Autologous Bone Marrow Obtained during Remission 1 November 1958Volume 49, Issue 5Page: 973-986KeywordsBone marrowBone marrow cellsHospital medicineIntravenous injectionsMedical servicesPrevention, policy, and public healthTechnicians ePublished: 1 December 2008 Issue Published: 1 November 1958 Copyright & PermissionsCopyright ©, 1958, by The American College of PhysiciansPDF downloadLoading ...