tbuckley/cabot-search huggingface dataset:
Serum levels of total IgE in non‐allergic children
Authors: F. A. Berciano, M. Crespo, C. G. Bao, F. V. Alvarez
Journal: Allergy (1987)

The purpose of this study was to establish the range of total serum IgE in a healthy population lacking personal and family history of allergy, as well as the influence of genetic factors (family history of allergy), environmental factors (degree of air pollution), age, and sex on the serum IgE levels. Using a commercial enzyme immunoassay (Phadezym® IgE Prist) the mean serum level of IgE was determined in 363 non‐atopic children from 0 to 12 years of age. The geometric mean of serum IgE increased according to age, indicating a positive correlation between both. Higher mean values of serum IgE were found for children with a family history of allergy, than for children without (27.82 and 14.49 U/ml respectively). The percentage of variation due to age was about 94.5 % in children with no family history of allergy. The mean value of serum IgE increased with the degree of air pollution in the living area (15.49 U/ml in non‐polluted areas, 20.78 U/ml in very polluted areas). However, the influence of air pollution was smaller than the influence of family history on the mean values of serum IgE. The mean value of serum IgE was not modified by sex.
Abstract 15528: Myocardial Deformation Imaging and Obstruction in Hypertrophic Cardiomyopathy, Insights from Cross-sectional and Post-myectomy Analysis
Authors: Yukari Kobayashi, Gherardo Finocchiaro, Genevieve Giraldeau, David Boulate, Yuhei Kobayashi, Richard Ha, David Lee, David Liang, Ingela Schittger, Francois Haddad, Euan Ashley
Journal: Circulation (2014)

Background: Hypertrophic cardiomyopathy (HCM) has been reported to alter left ventricular deformation. However, little is known about the differences of left ventricular (LV) strain values among healthy and varying levels of HCM patients including non-obstructive and obstructive, nor about the impact of septal reduction therapy on strain values. Methods: Age- and sex matched patients with HCM and varying degree of obstruction as well as 48 healthy controls were studied. Among HCM patients, 28 subjects had non-obstructive HCM, 27 had mildly symptomatic obstructive HCM, and 34 had HCM requiring septal reduction therapy (either myectomy or alcohol ablation). LV global longitudinal strain (LV-GLS) and circumferential strain as well as routine echocardiography were evaluated. Detailed LV longitudinal strain was assessed with septal and lateral longitudinal strain (Sept.-LS and Lat.-LS). In HCM patients treated with septal reduction, echocardiography was performed before, 3-months, and 1-year after the procedure. Results: LV-GLS, Sept.-LS, and Lat.-LS of all HCM patients were significantly lower than controls (p&lt;0.001, p&lt;0.001, p&lt;0.05, respectively), and circumferential endocardial and mid strain were higher (p&lt;0.05). Significant differences among controls and varying levels of HCM subgroups were detected only in Sept.-LS, which enabled to stratify the HCM severity (left panel in Figure). In addition, Sept.-LS has the strongest correlation with the average LV wall thickness (right panel in Figure). Furthermore, Sept.-LS was significantly improved after septal reduction, whereas Lat.-LS and circumferential strain did not change. Conclusions: The strongest relationship between myocardial deformation and obstruction in HCM was found for Sept.-LS. Also, septal reduction procedure preferentially improves Sept.-LS.
Abstract 15131: Beneficial Effects of Hydrophilic Statins on Prevention of Adverse Cardiac Events in Diabetic Patients after Acute Myocardial Infarction as Compared to Lipophilic Statins
Authors: Ryu Shutta, Masami Nishino, Ayano Ishiyama, Hiroyuki Oonishi, Akiya Sakatani, Akihiro Tanaka, Naotaka Okamoto, Atsushi Kikuchi, Naoki Mori, Takeshi Masaki, Yasuharu Lee, Takahiro Yoshimura, Daisuke Nakamura, Masayuki Taniike, Nobuhiko Makino, Hiroyasu Kato, Yasuyuki Egami, Hisaki Morita, Jun Tanouchi, Yoshio Yamada, Daisaku Nakatani, Yasuhiko Sakata, Issei Komuro
Journal: Circulation (2011)
Tumors Produced by Estradiol Benzoate in the Guinea Pig
Authors: Lorande M. Woodruff
Journal: Cancer Research (1941)

Nelson (4) injected 32 guinea pigs with various estrogens for periods ranging from 2 to io months, and in 6 of these animals succeeded in producing in the cornua or fundus of the uterus one or more growths which appeared to be definitely fibromyomatous. Lipschiitz (2) and collaborators, in an extended series of experiments, produced similar tumors not only on the uterus but on many of the abdominal organs, including the stomach, spleen, and omentum. He noted that ovariectomized guinea pigs almost invariably developed growths after the administration twice weekly for 2 to 3 months of 80 mgm. of estradiol benzoate. The tumors that resulted were not observed to undergo malignant change. A second group of 3 male guinea pigs received estradiol benzoate pellets in the same manner , without prel iminary operative procedure. Two pellets weighed 25 mgm., the third 5 ~ mgm. One of the animals with a 25 mgm. pellet was allowed to live 9 ~ days, the other two were kept for i48 days and then killed.
Abstract 4170: Oncogenic activation of LMO2 by EGFR signaling regulates STAT3 phosphorylation and transcriptional activity in human glioma
Authors: Jun Fu, Dimpy Koul, Shaofang Wu, Siyuan Zheng, Roel G. Verhaak, W.K Yung
Journal: Cancer Research (2014)

Abstract Glioblastoma multiforme (GBM) is a highly heterogeneous disease characterized by multiple genetic abnormalities. Amplification and mutation of the epidermal growth factor receptor (EGFR) gene represent signature genetic abnormalities occurred in over 60% of GBM. The successful application of EGFR-targeted therapy for the treatment of GBM is thus dependent on a thorough understanding of the intricate signal pathways cross-linkage that underlies the pathobiology of this disease. The LIM-domain only factor 2 (LMO2) gene is a crucial oncogene involved in hematopoietic development and leukemogenesis. Herein, we showed, from the TCGA GBM data, that LMO2 is highly expressed in EGFR-aberrant GBM samples and might serve as a downstream effector of EGFR signaling in GBM. Depletion of LMO2 expression impairs the maintenance of glioma cell proliferation in vitro and in vivo. In addition, EGFR signaling induces LMO2 nuclear translocation and enables LMO2 to form a triplex with EGFR and Signal transducer and activator of transcription 3 (STAT3). More importantly, LMO2 serves as a bridging molecule to promote the formation of EGFR/STAT3 complex and to enhance EGFR-mediated STAT3 Y705 phosphorylation upon EGF stimulation, which in turn up-regulates the expression of STAT3-responsive genes involved in the regulation of cell proliferation and tumor development. In conclusion, these findings reveal that LMO2 might serve as a critical effector of EGFR signaling in human glioma and highlight the essential function of LMO2 in EGF-stimulated STAT3 activation and tumorigenesis. Citation Format: Jun Fu, Dimpy Koul, Shaofang Wu, Siyuan Zheng, Roel G. Verhaak, W.K Yung. Oncogenic activation of LMO2 by EGFR signaling regulates STAT3 phosphorylation and transcriptional activity in human glioma. [abstract]. In: Proceedings of the 105th Annual Meeting of the American Association for Cancer Research; 2014 Apr 5-9; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2014;74(19 Suppl):Abstract nr 4170. doi:10.1158/1538-7445.AM2014-4170
Abstract 286: Epigenome-wide association study of normal lung tissues identifies hypomethylation of multiple CpG sites associated with cigarette smoking
Authors: Wen-Qing Li, Jianxin Shi, William Wheeler, Neil Caporaso, Ite Laird-Offspringa, Maria Teresa Landi
Journal: Cancer Research (2014)

Abstract Background: DNA methylation due to tobacco smoking have been reported in studies of blood genomic DNA, indicating a possible role of methylation changes due to smoking in multiple adverse health outcomes. Since DNA methylation is known to be tissue-specific, we profiled methylation in normal human lung tissues and evaluated the association with cigarette smoking based on a large sample size. Methods: We studied histologically normal lung tissues of 237 lung cancer patients (121 current cigarette smokers and 116 current nonsmokers) from the Environment And Genetics in Lung cancer Etiology study. DNA methylation was assayed using the Illumina Infinium HumanMethylation450 BeadChip arrays and methylation for 338,456 autosomal probes remained after quality control filters. We examined the association of log-transformed methylation with current smoking status, as well as with quantitative measures of smoking, using linear regression models adjusting for covariates. We sought to replicate the findings in The Cancer Genome Atlas normal lung samples (12 current smokers and 50 nonsmokers). Results: Eight CpG sites were significantly hypomethylated in lung tissues of current smokers after Bonferroni-correction (P&amp;lt;1.48×10-7). Of them, six were associated with smoking duration, pack-years and years from quitting smoking, and were replicated in TCGA samples (P&amp;lt;0.10), including cg17113147 (NXN), cg05575921 (AHRR), cg07992500 (CDC42EP3), cg14120703 (NOTCH1), cg11152412 (EDC3), and cg03224163 (HIPK2). These loci have not been reported in prior studies, except for cg05575921, which was shown to be hypomethylated in smokers in studies of blood DNA. Conclusions: Our study in lung tissues shows that smoking is associated with alterations in DNA methylation in genes involved in tobacco smoking metabolism or cancer progression. These findings suggest that smoking-associated epigenetic changes may have an important role in lung tumorigenesis. Citation Format: Wen-Qing Li, Jianxin Shi, William Wheeler, Neil Caporaso, Ite Laird-Offspringa, Maria Teresa Landi. Epigenome-wide association study of normal lung tissues identifies hypomethylation of multiple CpG sites associated with cigarette smoking. [abstract]. In: Proceedings of the 105th Annual Meeting of the American Association for Cancer Research; 2014 Apr 5-9; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2014;74(19 Suppl):Abstract nr 286. doi:10.1158/1538-7445.AM2014-286
Abstract 719: Development of systemically-deliverable telomerase-specific oncolytic adenovirus
Authors: Katsuyuki Aoyama, Shinji Kuroda, Hiroshi Tazawa, Shunsuke Kagawa, Toshiyoshi Fujiwara
Journal: Cancer Research (2014)

Abstract Background: Oncolytic virotherapy is an emerging treatment strategy that allows to destroy cancer tissues only but not normal tissues. We previously developed a telomerase-specific oncolytic adenovirus (Telomelysin) whose replication is controlled by the human telomerase reverse tran¬scriptase (hTERT) promoter, and the clinical safety and pharmacokinetics of Telomelysin has been already evaluated in the phase I clinical trial conducted in the US. While oncolytic adenoviruses can produce promising treatment efficacy, their application is basically limited to locoregional administration because of nonspecific trapping in the liver and neutralization by immune response after systemic delivery. Nano-sized materials have been identified as effective and attractive drug carriers in the fields of cancer treatment and diagnosis. Liposome is one of the most popular and widely-used drug carriers. In this study, we investigated the possibility of systemic delivery of telomerase-specific oncolytic adenoviral plasmid DNA via lipid encapsulation as an alternative approach to overcome the shortcomings of oncolytic adenovirotherapy. Methods: TelomeScan, a modified Telomelysin expressing the green fluorescence protein (GFP), is used in this study. Cytotoxic activity of TelomeScan plasmid DNAs encapsulated by liposomes (Lipo-TelomeScan-pDNA) against various types of human cancer cell lines including HCT 116, a human colorectal carcinoma cell line, and MKN1, a human gastric carcinoma cell line, were evaluated by XTT assay and compared with liposome complexes of GFP plasmid DNA controlled by the cytomegalovirus (CMV) promoter (Lipo-GFP-pDNA) as a control agent. Results: Freeze-thaw procedure proved that viable oncolytic adenoviruses were successfully produced in H1299, a human lung cancer cell line, after Lipo-TelomeScan-pDNA transfection. Lipo-TelomeScan-pDNA showed cytotoxic activity on various types of cancer cell lines. Lipo-TelomeScan-pDNA killed HCT116 and MKN1 cells in a dose-dependent manner and produced more effective cytotoxic activity than Lipo-GFP-pDNA. Conclusions: Lipo-TelomeScan-pDNA proved potent cytotoxic effects on cancer cells by producing viable oncolytic adenoviruses. In vivo examination is needed for the next step. Citation Format: Katsuyuki Aoyama, Shinji Kuroda, Hiroshi Tazawa, Shunsuke Kagawa, Toshiyoshi Fujiwara. Development of systemically-deliverable telomerase-specific oncolytic adenovirus. [abstract]. In: Proceedings of the 105th Annual Meeting of the American Association for Cancer Research; 2014 Apr 5-9; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2014;74(19 Suppl):Abstract nr 719. doi:10.1158/1538-7445.AM2014-719
Bilgisayarlı Tomografide Saptanan Pankreas Büyümesinde Endoskopik Ultrasonografinin Yeri Hakkında Tek Merkezli Bir Deneyim
Authors: Sammy Ho, Robert J. Bonasera, Bonnie J. Pollack, James Grendell, Martin Feuerman, sup> ve Frank Gress
Journal: Clinical Gastroenterology and Hepatology (2006)
Prognostic factors in the treatment of human immunodeficiency virus-associated non-Hodgkin's lymphoma: analysis of AIDS Clinical Trials Group protocol 142--low-dose versus standard-dose m-BACOD plus granulocyte-macrophage colony-stimulating factor. National Institute of Allergy and Infectious Diseases.
Authors: D J Straus, J Huang, M A Testa, A M Levine, L D Kaplan
Journal: Journal of Clinical Oncology (1998)

The overall results of chemotherapy in human immunodeficiency virus (HIV)-associated non-Hodgkin's lymphoma (NHL) have been poor. To define a subgroup of patients who may have a better outcome, an analysis of prognostic factors was performed of patients treated in AIDS Clinical Trials Group (ACTG) protocol 142, a phase III randomized trial of low-dose versus standard-dose methotrexate, bleomycin, doxorubicin, cyclophosphamide, vincristine, and dexamethasone (m-BACOD) plus granulocyte-macrophage colony-stimulating factor (GM-CSF) for the treatment of patients with newly diagnosed HIV-associated NHL.The following baseline variables were included as potential predictors of survival among 192 patients who received treatment: age; intravenous drug use (IVDU); specific type of sexual contact as risk factors (homosexual, bisexual, or heterosexual contact); prior AIDS diagnosis; CD4 cell count; serum lactic acid dehydrogenase (LDH); histology; Karnofsky performance status (KPS); stage; B symptoms; race (white/nonwhite); nodal involvement; extranodal involvement; number of extranodal sites; specific sites: bone marrow, liver, kidney, lung, or gastrointestinal tract; and treatment arm (standard-dose m-BACOD/low-dose m-BACOD).Age greater than 35 years, IVDU, stages III/IV, and CD4 cell counts less than 100/microL were adverse prognostic factors in multivariate analyses using the Cox proportional hazards model. The median overall survival for patients with none or one of the adverse factors was 46 weeks, with two was 44 weeks, and with three or four was 18 weeks. At 144 weeks, 29.5% of patients with none or one, 16.9% with two, and 0% with three or four factors were alive (P < .001).Long-term survival can be achieved in approximately one third of patients with HIV-associated NHL with favorable characteristics.
Acute magnesium administration and frequency of ventricular arrhythmia in heart failure.
Authors: P Bradding, N Withers
Journal: Circulation (1994)

with echocardiographs, including ours; the frequency area was 20 to 600 Hz, but the sensitivity was optimal at higher frequencies (>100 Hz).Finally, in defense of Circulation's "eagle-eyed custo- dians," we would like to add that one of the reviewers commented, like Dr Spodick, that there should have been two, preferably three, independent auscultators in our study.We admit that this would have improved our work, but we have no reason to believe that the results would have been different.
Halofantrine versus mefloquine in treatment of multidrug-resistant falciparum malaria
Authors: F.O. ter Kuile, F. Nosten, T. Chongsuphajaisiddhi, N.J. White, G. Dolan, C. Luxemburger, L. Phaipun, M.D. Edstein, H.K. Webster
Journal: The Lancet (1993)
CD56 expression in a case of primary cutaneous CD30+ anaplastic large cell lymphoma
Authors: S-E. Chang, I-J. Park, J. Huh, J-H. Choi, K-J. Sung, K-C. Moon, J-K. Koh
Journal: British Journal of Dermatology (2000)

Journal Article CD56 expression in a case of primary cutaneous CD30+ anaplastic large cell lymphoma Get access S‐E. Chang, S‐E. Chang Departments of Dermatology and Search for other works by this author on: Oxford Academic Google Scholar I‐J. Park, I‐J. Park Departments of Dermatology and Search for other works by this author on: Oxford Academic Google Scholar J. Huh, J. Huh Pathology, Asan Medical Center, College of Medicine, University of Ulsan, 388‐1 Poongnap‐Dong, Songpa‐Gu, Seoul 138‐736, Korea Search for other works by this author on: Oxford Academic Google Scholar J‐H. Choi, J‐H. Choi Departments of Dermatology and Search for other works by this author on: Oxford Academic Google Scholar K‐J. Sung, K‐J. Sung Departments of Dermatology and Search for other works by this author on: Oxford Academic Google Scholar K‐C. Moon, K‐C. Moon Departments of Dermatology and Kee‐Chan Moon. Search for other works by this author on: Oxford Academic Google Scholar J‐K. Koh J‐K. Koh Departments of Dermatology and Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 142, Issue 4, 1 April 2000, Pages 766–770, https://doi.org/10.1046/j.1365-2133.2000.03423.x Published: 01 April 2000
Impact of rapid point-of-care screening tests for the identification of chronic hepatitis C infection
Authors: AnnMarie Liapakis, Joseph K. Lim
Journal: Hepatology (2013)

Abstract Background: 170 million persons worldwide are infected with hepatitis C, many of whom are undiagnosed. Although rapid diagnostic tests (RDTs) and point-of-care tests (POCTs) provide a time- and cost-saving alternative to conventional laboratory tests, their global uptake partly depends on their performance. Purpose: To meta-analyze the diagnostic accuracy of POCTs and RDTs to screen for hepatitis C. Data Sources MEDLINE, EMBASE, BIOSIS, and Web of Science (1992 to 2012) and bibliographies of included articles. Study Selection: All studies evaluating the diagnostic accuracy of POCTs and RDTs for hepatitis C in adults (aged 18 years). Data Extraction: Two independent reviewers extracted data and critiqued study quality. Data Synthesis: Of 19 studies reviewed, 18 were meta-analyzed and stratified by specimen type (whole blood, serum, plasma, or oral fluid) or test type (POCT or RDT). Sensitivity was similarly high in POCTs of whole blood (98.9% [95% CI, 94.5% to 99.8%]) and serum or plasma (98.9% [CI, 96.8% to 99.6%]), followed by RDTs of serum or plasma (98.4% [CI, 88.9% to 99.8%]) and POCTs of oral fluid (97.1% [CI, 94.7% to 98.4%]). Specificity was also high in POCTs of whole blood (99.5% [CI, 97.5% to 99.9%]) and serum or plasma (99.7% [CI, 99.3% to 99.9%]), followed by RDTs of serum or plasma (98.6% [CI, 94.9% to 99.6%]) and POCTs of oral fluid (98.2% [CI, 92.2% to 99.6%]). Limitation: Lack of data prevented sensitivity analyses of specific tests. Conclusion: Data suggest that POCTs of blood (serum, plasma, or whole blood) have the highest accuracy, followed by RDTs of serum or plasma and POCTs of oral fluids. Given their accuracy, convenience, and quick turnaround time, RDTs and POCTs may be useful in expanding first-line screening for hepatitis C. Primary Funding Source: Canadian Institutes of Health Research.
Characterization of T-Cell Repertoire of the Bone Marrow in Immune-Mediated Aplastic Anemia: Evidence for the Involvement of Antigen-Driven T-Cell Response in Cyclosporine-Dependent Aplastic Anemia
Authors: Weihua Zeng, Shinji Nakao, Hideyuki Takamatsu, Akihiro Yachie, Akiyoshi Takami, Yukio Kondo, Naomi Sugimori, Hirohito Yamazaki, Yuji Miura, Shintaro Shiobara, Tamotsu Matsuda
Journal: Blood (1999)
VENTRICULAR TACHYCARDIA WITH ELECTRICAL ALTERNANS RESULTING FROM DIGITALIS EXCESS
Authors: J H CURRENS, R C WOODARD
Journal: Annals of Internal Medicine (1947)

Case Reports1 January 1947VENTRICULAR TACHYCARDIA WITH ELECTRICAL ALTERNANS RESULTING FROM DIGITALIS EXCESSJ. H. CURRENS, M.D., R. C. WOODARD, M.D.J. H. CURRENS, M.D., R. C. WOODARD, M.D.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-26-1-120 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe electrocardiographic picture of ventricular tachycardia is usually quite characteristic, and although the rhythm is as a rule slightly irregular, the ventricular complexes are quite uniform in appearance. Regular alternation in the direction of the QRS complexes during ventricular tachycardia has been reported by various authors, and, in the majority of cases digitalis intoxication has been responsible for the tachycardia.1-4We should like to present the following case report and electrocardiogram demonstrating alternation in the amplitude of the QRS complexes without an alternation in the direction of the complexes. This has the appearance of electrical alternans and is presented because...Bibliography1. FELBERBAUM D: Paroxysmal ventricular tachycardia, report of a case of unusual type, Am. Jr. Med. Sci., 1923, clxvi, 211. CrossrefGoogle Scholar2. MARVIN NM: Paroxysmal ventricular tachycardia with alternating complexes due to digitalis intoxication, Am. Heart Jr., 1928, iv, 21. CrossrefGoogle Scholar3. PALMERWHITE RSPD: Paroxysmal ventricular tachycardia with rhythmic alternation in direction of the ventricular complexes, Am. Heart Jr., 1928, iii, 454. CrossrefGoogle Scholar4. BRAUSWASIKA KPH: Bidirectional paroxysmal tachycardia: toxicity of different cardiac glycosides, Am. Heart Jr., 1945, xxix, 261. Google Scholar5. SCHERFKISCH DF: Ventricular tachycardias with variform complexes, Bull. New York Med. Coll. Flower and Fifth Avenue Hosp., 1939, ii, 73. Google Scholar6. KALTERGRISHMAN HHA: The electrical alternans, Jr. Sinai Hosp., 1943, x, 459. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Miami, Florida*Received for publication September 14, 1945. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byAlternation of the HeartThe effect of quinidine on tolerance to digoxin∗Paroxysmal ventricular tachycardia of prolonged durationThe effect of digitoxin on the V leads 1 January 1947Volume 26, Issue 1Page: 120-125KeywordsElectrocardiographyIntoxicationVentricular tachycardia Issue Published: 1 January 1947 PDF downloadLoading ...