IMMUNOLOGICAL APPLICATIONS OF PLACENTAL EXTRACTS; EFFECTIVENESS BY ORAL ADMINISTRATION
Authors: C. F. Mckhann, A. A. Green, L. E. Eckles, J. A. V. Davies
Journal: Annals of Internal Medicine (1935)

Article1 October 1935IMMUNOLOGICAL APPLICATIONS OF PLACENTAL EXTRACTS; EFFECTIVENESS BY ORAL ADMINISTRATIONC. F. MCKHANN, A. A. GREEN, L. E. ECKLES, J. A. V. DAVIESC. F. MCKHANNSearch for more papers by this author, A. A. GREENSearch for more papers by this author, L. E. ECKLESSearch for more papers by this author, J. A. V. DAVIESSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-9-4-388 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptA number of investigators have found that the umbilical cord blood of infants contains certain antibodies in amounts commensurate with those in the maternal blood stream.1 This would indicate that the immunity of the newborn infant to some of the infectious diseases is derived in part by placental transmission of antibodies from the mother. Protein extracts composed of the globulins derived from the human placenta and the blood contained in it have been prepared and have been demonstrated to contain diphtheria and scarlet fever antitoxins, and antibodies which neutralize poliomyelitis virus and protect exposed, susceptible children against measles.2In the...Bibliography1. VON GROËRKASSOWITZ FK: Studien über die normale Diphtherieimmunität des Menschen, Ztschr. f. Immunitätsforsch, u. exper. Therap., 1914, xxii, 404-450; ibid., 1914, xxiii, 108-126. KUTTNER, A. G., and RATNER, B.: Importance of colostrum to new-born infant, Am. Jr. Dis. Child., 1923, xxv, 413-434. PAUNZ, J., and CSOMA, E.: Ensteht die Scharlachimmunität der Neugeborenen auf plazentarem Wege oder durch die Laktation?, Jahrb. f. Kindern., 1930, cxxvi, 181-186. AYCOCK, W. L., and KRAMER, S. D.: Immunity to poliomyelitis in mothers and newborn as shown by neutralization test, Jr. Exper. Med., 1930, lii, 457-464. FINKELSTEIN, G. S.: Prevention of measles with puerperal serum, Vrach. delo, 1931, xiv, 794-795; abstr., Jr. Am. Med. Assoc., 1932, xcviii, 92. JORGE, R.: Sur la séro-prévention de la rougeole au moyen du sang placentaire, Bull. Office internat. d'hyg. pub., 1932, xxiv, 978-983. DE SOUZA, J. S.: L'immunisation contre la rougeole par le sang du placenta, Arch. de méd. d. enf., 1932, xxxv, 633. Google Scholar2. MCKHANNCHU CFFT: Antibodies in placental extracts, Jr. Infect. Dis., 1933, lii, 268-277. MCKHANN, C. F., and CHU, F. T.: Use of placental extract in prevention and modification of measles, Am. Jr. Dis. Child., 1933, xlv, 475-479. CrossrefGoogle Scholar3. MCKHANNGREENCOADY CFAAH: Factors influencing the effectiveness of placental extract in the prevention and modification of measles, Jr. Pediat., 1935. vi, 603. CrossrefGoogle Scholar4. ELEY RC: N. E. Jr. Med. (In press.) Google Scholar5. MCKHANNCOADY CFH: Immunity in infants to infectious diseases; placental antibodies, South. Med. Jr., 1934, xxvii, 20-24. CrossrefGoogle Scholar6. DEBRÉ R: Sero-Abschwachung und Immunität gegen Masern, Arch. f. Kinderh., 1932, xcv, 169-175. Google Scholar7. SCHENK F: Schutzeffekte normaler Sera gegen die Wirkung menschlichen Placentasaftes beim Kaninchen, Zentralbl. f. Gynäk., 1909, xxxiii, 1353-1356. GAIFAMI, P.: Toxicity of aqueous placental extracts and the detoxifying action of blood serum, Pathologica, 1914, v, 415; also in Zentralbl. Biochem. Biophys., 1914, xvii, 74. OBATA, I.: Detoxicating power of the body toward placental poisons, Tokyo Igakukai Zasshi, 1916, xxii, 19; also in Japanese Med. Lit., 1917, iv, 2. HAYASHI, T.: Antitoxic action of serum on placenta toxin, Arch. f. Gynäk., 1923, cxix, 29-56. Google Scholar8. MILLS CA: Absorption from intestine and excretion through kidney of an unaltered complex protein substance, tissue fibrinogen, Am. Jr. Physiol., 1923, lxiii, 484-498. CrossrefGoogle Scholar9. SAKURAI K: Studies on toxicity of human placenta upon rabbits and its accelerative influence upon coagulation of blood, and on its chemical nature, Sei-I-Kwai Med. Jr., 1929, xlviii, 4-6. Google Scholar10. RATNERGRUEHL BHL: Passage of native proteins through normal gastrointestinal wall, Jr. Clin. Invest., 1934, xiii, 517-532. CrossrefGoogle Scholar11. ROSS AS: The effect of placental extract on the Dick test, Jr. Pediat., 1935, vi, 546. CrossrefGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Boston, Massachusetts*Read in part at the Philadelphia meeting of the American College of Physicians, May 1, 1935.From the Department of Pediatrics, Harvard Medical School, the Department of Communicable Diseases, Harvard School of Public Health, and the Infants' and Children's Hospitals, Boston, Mass.†The investigations reported herein were supported by a grant from the Commonwealth Fund of New York. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byMEASLESThe use of a blood coagulant extract from the human placenta in the treatment of hemophilia 1 October 1935Volume 9, Issue 4Page: 388-397KeywordsAntibodiesBloodChildrenInfantsPediatricsPlacentaPoliomyelitisPrevention, policy, and public healthProteinsScarlet fever ePublished: 1 December 2008 Issue Published: 1 October 1935 PDF downloadLoading ...