tbuckley/cabot-search huggingface dataset:
Right Ventricular Diastolic Dysfunction in Heart Failure
Authors: C.M. Yu, J.E. Sanderson, Skiva Chan, Leata Yeung, Y.T. Hung, K.S. Woo
Journal: Circulation (1996)

Left ventricular (LV) diastolic dysfunction is common in heart failure and is an important predictor of prognosis and mortality. Less attention has been paid to right ventricular (RV) diastolic function. In this study, we compared RV diastolic function in a large cohort of patients with heart failure (HF) with two groups: patients with pulmonary hypertension and normal LV function (the PHT group) and normal subjects.Transtricuspid and pulmonary artery flow were assessed by two-dimensional Doppler echocardiography at maximum inspiration and expiration in 185 subjects: 114 symptomatic HF patients (ejection fraction < 0.5), 31 PHT patients (pulmonary artery systolic pressure > 40 mm Hg), and 40 normal subjects. A subset was matched for age and heart rate. The results showed a high prevalence of RV diastolic abnormalities: HF patients had lower tricuspid E-A ratios, lower peak E-wave velocity, and prolonged RV isovolumic relaxation time (all P< .0001). Tricuspid E-wave deceleration time was significantly shorter only in those who had an LV restrictive filling pattern. The PHT group had similar findings. Compared with a normal range, more than half of the patients had lower tricuspid E-A ratios (HF, 55%; PHT, 69%), and 61% of HF and 58% of PHT patients had a prolonged RV isovolumic relaxation time. In the PHT group, RV diastolic parameters (E-wave deceleration time, E-A ratio, and isovolumic relaxation time) correlated significantly with pulmonary artery systolic pressure (P< .05). In the HF group, however, only tricuspid E-wave deceleration time correlated significantly with pulmonary artery systolic pressure, and HF patients with normal pulmonary artery systolic pressures had significantly lower tricuspid E-A ratios and prolonged RV isovolumic relaxation times compared with normal subjects. A close correlation existed between individual RV and LV diastolic parameters, suggesting that LV diastolic dysfunction may directly affect RV function, but there was no relation between LV size or systolic function and RV diastolic dysfunction.RV diastolic function is frequently abnormal in HF patients, and this is not related to elevated pulmonary artery systolic pressure alone, although high pulmonary artery pressure by itself also is associated with impaired RV diastolic function. Assessment of the role of right ventricular diastolic function in determining the symptoms and prognosis of heart failure is warranted.
Antidepressant prescribing and suicide: Authors' reply
Authors: W. D Hall
Journal: BMJ (2003)

EDITOR—Our critical finding was the relation between decline in suicide rate and exposure to antidepressants across age groups in both sexes. We agree that time series data must be interpreted cautiously; that is why we considered alternative explanations.

We disagree with Moncrieff that we should have used ratios of daily dependent doses. This would have been an alternative measure of change in exposure but not of overall antidepressant exposure. We agree that the daily dependent doses will underestimate prescribing levels of tricyclic …
THE EXPERIENCE OF SYRACUSE, N. Y., WITH THE COMPULSORY TUBERCULIN TEST OF ALL DAIRIES FURNISHING MILK TO THE CITY.
Authors: B. S. MOORE
Journal: JAMA (1902)

The object of this paper is not a desire to advance something new in regard to tuberculosis or tuberculin, but rather to call your attention to the great merit of tuberculin as used to-day in veterinary practice, and recite the experience of Syracuse in its use'for the past four years. This experience has impressed me with its great value as a means of diagnosing bovine tuberculosis, and the hope that prompted the presentation of this paper is that such testing may soon become general and that the tubercle bacilli may be driven from the milk supply of our entire country. I am not of those who believe that the tubercle bacillus of infected milk is the principal cause of tuberculosis in man; though not the principal, I do believe it to be a very important cause, next perhaps to the most important—that of direct infection from the infected to the
Efficacy of cumulative doses of salbutamol administered via Turbuhaler® or Diskhaler® in patients with reversible airway obstruction
Authors: L‐G. Carlsson, E. Arweström, K. Friberg, A. Källén, H. Lunde, C.‐G. Löfdahl
Journal: Allergy (1998)

The study aimed to estimate the relative dose potency of salbutamol inhaled via Turbuhaler® and Diskhaler®. The 24 adult patients participating had chronic reversible airway obstruction. The study was of a double‐blind, double‐dummy, crossover, randomized design. Five doses of salbutamol Turbuhaler, 50, 50. 100, 200, and 400 ng, were given on one study day at intervals of 30 min. On another study day, five doses of salbutaniol Diskhaler, 200,200,400,800, and 1600 ng, were given with the same interval. The treatment days were separated by a washout period of at least 24 h. The inhalation technique was standardized and supervised. Efficacy variables were recorded before and after each study dose. The primary efficacy variable was forced expiratory volume in 1 s (FEVi). When parallel and linear cumulative dose‐response curves were statistically compared on a logarithmic scale, the dose potency of salbutamol Turbuhaler v.v salbutamol Diskhaler was 1.99 (95% confidence interval 1.52–2.54). This study indicates that only half the dose of salbutamol is required via Turbuhaler as via Diskhaler for the same bronchodilating effect.
A Synthetic Lethal Interaction between K-Ras Oncogenes and Cdk4 Unveils a Therapeutic Strategy for Non-small Cell Lung Carcinoma
Authors: Marta Puyol, Alberto Martín, Pierre Dubus, Francisca Mulero, Pilar Pizcueta, Gulfaraz Khan, Carmen Guerra, David Santamaría, Mariano Barbacid
Journal: Cancer Cell (2010)
Cardiac Toxicity of Methylphenidate
Authors: Robert W. Chernoff, Marven H. Wallen, Otto F. Müller
Journal: New England Journal of Medicine (1962)

METHYLPHENIDATE, a cerebrocortical stimulant, has been studied in a wide variety of clinical settings for its mood-elevating effects. Recently, it has been used in the treatment of drug-induced lethargy and oversedation.1 Mild side effects such as anorexia, flushing, dizziness, palpitations, insomnia, headache and blood-pressure changes in both directions have been observed.2 , 3 The episode of a rapid paroxysm of atrial fibrillation that followed the intravenous use of methylphenidate, illustrated in the case reported below, is believed to be the first so documented.Case ReportsCase 1. H.B., a 60-year-old man, was admitted to the Philadelphia General Hospital on August 8, 1961, . . .
Medicine and Nursing: Professions in a Changing Health Service
Authors: A. Kitson
Journal: BMJ (1995)

Sylvia Walby, June Greenwell, Sage Publications, pounds sterling11.95, pp 224, ISBN 0 8039 87420

Perhaps there is some comfort in realising that the massive changes we have experienced in the health service have been matched with similar levels of what one author describes as “grotesque turbulence” in almost every other public sector. For this reason alone Medicine and Nursing: Professions in a …
CHANGES IN THE BONE MARROW AND BLOOD CELLS OF DEVELOPING RABBITS
Authors: F. R. Sabin, F. R. Miller, K. C. Smithburn, R. M. Thomas, L. E. Hummel
Journal: The Journal of Experimental Medicine (1936)

1. The full number of erythroid cells in the blood stream of the rabbit is reached by the 3rd week of life. 2. During this period, there is a predominance of erythrogenesis in the bone marrow. 3. During the 2nd week of life the bone marrow is in a state of hyperplasia owing to the needs of the body for blood and the small space available for the marrow. 4. This hyperplasia is reduced as the growth of the bone permits the marrow to spread. The control of the growth of the bones has an important bearing on hematopoiesis. 5. During the first 3 weeks of life, the chemical factors for the multiplication of red cells as well as for the elaboration of hemoglobin become available. 6. The amount of hemoglobin does not increase as rapidly as the number of cells, so that the macrocytic anemia of the fetus becomes reduced. The proportion of hemoglobin per red cell characteristic of the adult rabbit is reached by the 3rd month. 7. Further evidence on the intravascular origin of red blood cells is given. 8. The development of all of the white blood cells, with the exception of the monocyte, goes on at a slower rate than that of the red cells. 9. The monocytes reach their full number in the blood stream in the 1st week of life; granulocytes and lymphocytes by the 5th and 6th months. 10. Each of the three strains of white cells has a different rate of development. 11. The question as to whether the stem cell or primitive cell is identical with the lymphocyte is discussed.
Risk of prevalent HIV infection associated with incarceration among injecting drug users in Bangkok, Thailand: case-control study
Authors: A. Buavirat
Journal: BMJ (2003)

To identify risks for HIV infection related to incarceration among injecting drug users in Bangkok, Thailand.Case-control study of sexual and parenteral exposures occurring before, during, and after the most recent incarceration.Metropolitan Bangkok.Non-prison based injecting drug users formerly incarcerated for at least six months in the previous five years, with documented HIV serostatus since their most recent release; 175 HIV positive cases and 172 HIV negative controls from methadone clinics.Injection of heroin and methamphetamine, sharing of needles, sexual behaviour, and tattooing before, during, and after incarceration.In the month before incarceration cases were more likely than controls to have injected methamphetamine and to have borrowed needles. More cases than controls reported using drugs (60% v 45%; P=0.005) and sharing needles (50% v 31%; P<0.01) in the holding cell before incarceration. Independent risk factors for prevalent HIV infection included injection of methamphetamine before detention (adjusted odds ratio 3.3, 95% confidence interval 1.01 to 10.7), sharing needles in the holding cell (1.9, 1.2 to 3.0), being tattooed while in prison (2.1, 1.3 to 3.4), and borrowing needles after release (2.5, 1.3 to 4.4).Injecting drug users in Bangkok are at significantly increased risk of HIV infection through sharing needles with multiple partners while in holding cells before incarceration. The time spent in holding cells is an important opportunity to provide risk reduction counselling and intervention to reduce the incidence of HIV.
Parotid Carcinoma and Posterior Fossa Schwannoma Following Irradiation
Authors: Richard L. Sogg
Journal: JAMA (1977)

A 23-year-old man had received irradiation for a benign ear problem at the age of 1 year. Twenty years later, a malignant left parotid carcinoma and a right jugular foramen schwannoma developed. Earlier reports in the literature suggest that radiation can induce tumors in the head and neck. The localization of both tumors and the histological features of the parotid tumor suggest that they were radiation-induced. (<i>JAMA</i>237:2098-2100, 1977)
Studies in Humans and Mice Implicate Neurocan in the Etiology of Mania
Authors: Xavier Miró, Sandra Meier, Marie Luise Dreisow, Josef Frank, Jana Strohmaier, René Breuer, Christine Schmäl, Önder Albayram, María Teresa Pardo-Olmedilla, Thomas W. Mühleisen, Franziska A. Degenhardt, Manuel Mattheisen, Iris Reinhard, Andras Bilkei-Gorzo, Sven Cichon, Constanze Seidenbecher, Marcella Rietschel, Markus M. Nöthen, Andreas Zimmer
Journal: American Journal of Psychiatry (2012)

Genome-wide association has been reported between the NCAN gene and bipolar disorder. The aims of this study were to characterize the clinical symptomatology most strongly influenced by NCAN and to explore the behavioral phenotype of Ncan knockout (Ncan(-/-)) mice.Genotype/phenotype correlations were investigated in patients with bipolar disorder (N=641) and the genetically related disorders major depression (N=597) and schizophrenia (N=480). Principal components and genotype association analyses were used to derive main clinical factors from 69 lifetime symptoms and to determine which of these factors were associated with the NCAN risk allele. These analyses were then repeated using the associated factor(s) only in order to identify the more specific clinical subdimensions that drive the association. Ncan(-/-) mice were tested using diverse paradigms, assessing a range of behavioral traits, including paradigms corresponding to bipolar symptoms in humans.In the combined patient sample, the NCAN risk allele was significantly associated with the "mania" factor, in particular the subdimension "overactivity." Ncan(-/-) mice were hyperactive and showed more frequent risk-taking and repetitive behaviors, less depression-like conduct, impaired prepulse inhibition, amphetamine hypersensitivity, and increased saccharin preference. These aberrant behavioral responses normalized after the administration of lithium.NCAN preferentially affected mania symptoms in humans. Ncan(-/-) mice showed behavioral abnormalities that were strikingly similar to those of the human mania phenotype and may thus serve as a valid mouse model.
Dead children from problem families in NE Wiltshire.
Authors: J E Oliver
Journal: BMJ (1983)

Analysis of 147 families in NE Wiltshire known to have suffered child neglect or abuse over two generations showed than in 21 years 560 children had been born. Of these, 513 were known to have been neglected or assaulted or both; 41 out of 560 had died. Only three deaths led to criminal convictions. Detailed collated confidential information indicated that parental behaviour towards the dead children, in particular those aged from 5 weeks to 1 year, had often caused or contributed to their deaths, including some claimed to be clear-cut cases of accident or illness.
Transference and Counter – Transference in Analytical Group Counseling
Authors: Hans A. Illing
Journal: Psychotherapy and Psychosomatics (1962)

Research Articles| February 10 2010 Transference and Counter – Transference in Analytical Group Counseling Subject Area: Psychiatry and Psychology Hans A. Illing Hans A. Illing Los Angeles, Calif. Search for other works by this author on: This Site PubMed Google Scholar Acta Psychotherapeutica et Psychosomatica (1962) 10 (1): 13–25. https://doi.org/10.1159/000285615 Article history Published Online: February 10 2010 Content Tools Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Facebook Twitter LinkedIn Email Tools Icon Tools Get Permissions Cite Icon Cite Search Site Citation Hans A. Illing; Transference and Counter – Transference in Analytical Group Counseling. Acta Psychotherapeutica et Psychosomatica 1 January 1962; 10 (1): 13–25. https://doi.org/10.1159/000285615 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAll JournalsActa Psychotherapeutica et Psychosomatica Search Advanced Search Article PDF first page preview Close Modal This content is only available via PDF. 1962Copyright / Drug Dosage / DisclaimerCopyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher.Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. You do not currently have access to this content.
Does enough quality of life-related discussion occur during dermatology outpatient consultations?
Authors: S.E. David, Z. Ahmed, M.S. Salek, A.Y. Finlay
Journal: British Journal of Dermatology (2005)

Dermatologists' assessments of how their patients' lives are affected by the skin disease are of importance for informing clinical decisions. However, there is no information about how often quality of life (QoL) issues are discussed in outpatient consultations.To examine the relationship between the extent of QoL-related discussion during dermatology outpatient consultations, and the current impact of the disease on patients' lives.A total of 238 consultations were observed in a teaching dermatology outpatient department for QoL-related discussion initiated by either the clinician or the patient. Following the consultation, all patients were posted a Dermatology Life Quality Index (DLQI) questionnaire to complete and return within 1 week.QoL discussion was absent in 40% of consultations. Consultants initiated the fewest QoL discussions with patients, and nurses the most (P < 0.0001). One hundred and twenty-eight (54%) patients returned the DLQI, 114 (48%) of which were evaluable. The mean score was 5.6, SD +/- 6.6, median 3, range 0-29. The mean DLQI score for the patients with whom there was no QoL discussion was 4.0 +/- 4.7, n = 55, compared with the mean DLQI score for patients with whom QoL was discussed 6.8 +/- 7.2, n = 59 (P < 0.001).This study demonstrates that little information concerning QoL is elicited during dermatology outpatient consultations.
Case of Ovarian Tumor impeding Delivery
Authors: C. T. Edwards
Journal: BMJ (1842)

OVARIAN TUMIOR IMPEDING DELIVERY.there was some slightlhicmorrhage after the urine had been evacuated; has some pain in the loins; pulse ratlher strong; was at first cupped on the loins, and ordered aperients; and then diosma and the pareira brava, with opiates, were given in succession.After having attended for three weeks, he complained of somne pain in the joints, for which he was ordered colchicum, and though it greatly relieved the rheu- matic affection, produced no beneficial effect uipon the state of the bladder.Mr. Soden saw himn, and directed the mixture, with benzoic acid and balsam of copaiba.He found benefit after usiIIg it for two days, anld in ten days was perfectly wvell.CASE I1.-A married woman, apparently in good health, was admitted as an out-patient, stating tlhat she had frequent desire to make water; the urine depopositing on cooling (she says) a whitish sediment; urine slightly acid; she has been under medical treat- ment at intervals during the last six months, but with- out deriviing any benefit from the means adopted.The mixture, with benzoic acid and balsam of copaiba, was ordered immediately, and she was discharged, cured, in three weeks.CASE III.-A man, aged fifty, has been under the care of two surgeons for a month, owing to having suffered from irritability of the bladder.Has now frequent desire to make water; a small quantity of blood is occasionally passed witlh the last drop of
Early postoperative feeding with elemental diet.
Authors: S Sagar, P Harland, R Shields
Journal: BMJ (1979)

The value of early postoperative feeding with an elemental diet was assessed in 30 patients after major gastrointestinal operations. The patients were allocated at random to conventional treatment (control group) or feeding with the elemental diet (ED group). The clinical and metabolic course of the 15 patients in the ED group was significantly better than that of the controls. Patients in the ED group lost less weight and had a shorter stay in hospital. Negative nitrogen balance was more pronounced in the control group throughout the seven postoperative days. Energy intake was higher in the ED group. Provided elemental feeding is used with caution, it may be given from the first postoperative day. Patients do better metabolically and require shorter stays in hospital.
Cyclosporin A induces erythroid differentiation of K562 cells through p38 MAPK and ERK pathways
Authors: Kanoko Sawafuji, Yoshitaka Miyakawa, Masahiro Kizaki, Yasuo Ikeda
Journal: American Journal of Hematology (2002)

We studied the effects of cyclosporin A (CsA) on the erythroid differentiation of human erythroid leukemia cell line K562. After K562 was treated with CsA for 4 days, the percentage of hemoglobinized cells was increased by 3.3 times. Because it was reported p38 MAPK (p38) and ERK are involved in erythropoietin-induced erythroid differentiation, we studied their roles using specific inhibitors. p38 inhibitor (SB203580) prevented CsA-induced hemoglobin synthesis in K562 cells, although MEK/ERK inhibitor (U0126) enhanced it by 3.3 times in K562 cells. These results indicate activation of p38 and inactivation of ERK are involved in CsA-induced erythroid differentiation of K562 cells.
A Case of Symmetric Bilateral Agenesis of the Uterus (Rokitansky-Kuster's Syndrome): Diagnosed by Peritoneoscopy
Authors: N. Cortesi, A. Bertaglia, A. Manenti, M. Speranza
Journal: Endoscopy (1972)

The authors report a case of symmetric bilateral agenesis of the uterus, or Rokitansky-Kuster's syndrome, diagnosed by peritoneoscopy.
Takayasu's arteritis associated with Factor V Leiden
Authors: Daniel D. Shin, John E. Godwin
Journal: American Journal of Hematology (1999)

Takayasu's arteritis (TA) is a rare, chronic, and idiopathic vasculitis of the aorta and/or its main branches. There have been case reports of this disease associated with immune hypercoaguable states, namely raised antiphospholipid antibodies. Investigations of the thrombotic nature of Takayasu' arteritis have shown elevated levels of B-thrombo- globulin, platelet factor 4, thrombin-antithrombin III complex, and fibrinopeptide A. We report the first case of TA associated with the Factor V Leiden gene defect (Activated Protein C Resistance). The patient is a 30-year-old female who presented with six months of bilateral lower and upper extremity claudication, carotid artery tenderness, diminished brachial pulse and no measurable blood pressure in the left arm, an erythrocyte sedimentation rate (Westergren) of 62 mm/hr, and an angiogram meeting the clinical criteria for TA. Her symptoms showed a dramatic response to high-dose oral glucocorticosteroids and she was also maintained on long-term anticoagulation. This case illustrates that hereditary hypercoagulable states can coexist with acquired vasculitidies and that further investigation into these associations and their pathophysiologic interaction is warranted. Am. J. Hematol. 60:237–238, 1999. © 1999 Wiley-Liss, Inc.