tbuckley/cabot-search huggingface dataset:
Response to Commentary by W. Keith C. Morgan
Authors: Harvey W. Phelps
Journal: JAMA (1975)

To the Editor.—  Dr Morgan makes a number of statements in his commentary (231:1347,1975) that I believe are misleading and are certainly not founded on facts, particularly in the Rocky Mountain states.  At the National Conference on Medicine and the Coal Mine Health and Safety Act of 1969 held in Washington, DC, June 15 to 18,1970,I commented that ventilatory studies were of little or no help in determining disability in the coal miner who is working at the high altitudes found in Colorado and New Mexico. I further made the statement that the only way to assess disability in the coal miner is to do arterial blood gas determinations at rest and exercise (National Conference of Medicine and the Federal Coal Mine Health and Safety Act of 1969, Washington, DC, 1974).  My report describes the results of a study on 256 working coal miners in Colorado and New Mexico ( Rocky
Clinical significance of CD81 expression by clonal plasma cells in high-risk smoldering and symptomatic multiple myeloma patients
Authors: B Paiva, N-C Gutiérrez, X Chen, M-B Vídriales, M-Á Montalbán, L Rosiñol, A Oriol, J Martínez-López, M-V Mateos, L López-Corral, E Díaz-Rodríguez, J-J Pérez, E Fernández-Redondo, F de Arriba, L Palomera, E Bengoechea, M-J Terol, R de Paz, A Martin, J Hernández, A Orfao, J-J Lahuerta, J Bladé, A Pandiella, J-F San Miguel
Journal: Leukemia (2012)
PNPLA1 mutations cause autosomal recessive congenital ichthyosis in golden retriever dogs and humans
Authors: Anaïs Grall, Eric Guaguère, Sandrine Planchais, Susanne Grond, Emmanuelle Bourrat, Ingrid Hausser, Christophe Hitte, Matthieu Le Gallo, Céline Derbois, Gwang-Jin Kim, Laëtitia Lagoutte, Frédérique Degorce-Rubiales, Franz P W Radner, Anne Thomas, Sébastien Küry, Emmanuel Bensignor, Jacques Fontaine, Didier Pin, Robert Zimmermann, Rudolf Zechner, Mark Lathrop, Francis Galibert, Catherine André, Judith Fischer
Journal: Nature Genetics (2012)
Genetic variation in SCN10A influences cardiac conduction
Authors: John C Chambers, Jing Zhao, Cesare M.N. Terracciano, Connie R. Bezzina, Weihua Zhang, Riyaz Kaba, Manoraj Navaratnarajah, Amol Lotlikar, Joban S. Sehmi, Manraj K. Kooner, Guohong Deng, Urszula Siedlecka, Saurabh Parasramka, Ismail El-Hamamsy, Mark N. Wass, Lukas R.C. Dekker, Jonas S.S.G. de Jong, Michael J.E. Sternberg, William McKenna, Nicholas J Severs, Ranil de Silva, Arthur A.M. Wilde, Praveen Anand, Magdi H. Yacoub, James Scott, Paul Elliott, John N. Wood, Jaspal S Kooner
Journal: Nature Genetics (2010)
Thyrotoxicosis and Abdominal Pain
Authors: Steven M. Snyder
Journal: JAMA (1981)

<h3>To the Editor.—</h3> Although it has been reported in the literature,<sup>1</sup>abdominal pain is now rarely seen as a primary manifestation of hyperthyroidism. Also, the inability to swallow saliva has not been regarded as a manifestation of thyrotoxicosis. We describe a patient whose unusual symptoms of abdominal pain and spitting masked the diagnosis of thyrotoxicosis. <h3>Report of a Case.—</h3> A 44-year-old man was admitted to the Kaiser/Permanente Medical Center in Hayward, Calif, in February 1979 with a one-month history of an 18-kg weight loss and vague diffuse abdominal pain. Physical examination findings were normal except for a pulse rate of 100 beats per minute and a generalized abdominal tenderness. His weight was 97 kg and his face expressionless. No goiter was at first appreciated because of a "bull neck." There was no evidence of congestive heart failure or hepatomegaly. Attention was focused on his abdomen, and numerous x-ray films,
Treatment of Heat Stroke-Reply
Authors: Elsie F. Meyers
Journal: JAMA (1983)

In Reply.—  Unfortunately, controlled studies of patients with various types of thermic stress have not been done. Therefore, causal mechanisms are not as fully understood as Dr Knochel suggests. His statement that muscle rigidity is absent in heat stroke is incorrect, for heat stroke and malignant hyperthermia may both cause muscle rigidity, although it is not invariably found in either condition. In fact, heat stroke has been classified into myonecrotic and non-myonecrotic types. Muscle damage, elevations of muscle enzyme levels, myoglobinuria, and renal tubular failure may occur in heat stroke as well as in malignant hyperthermia. Patients with heat stroke, like those with malignant hyperthermia, may die with uncontrolled temperature elevations. 1   The relationships between these syndromes have been ill defined but must be considered if appropriate study and treatment is to evolve. The treatment of thermic stress of all types should emphasize the emergent need for discontinuing triggering factors
A3.5 Toll like receptors: a crossroad in scleroderma etiopathogenesis
Authors: CB Chighizola, E Raschi, L Cesana, S Uceda, MO Borghi, PL Meroni
Journal: Annals of the Rheumatic Diseases (2014)

<h3>Background and Objective</h3> Systemic sclerosis (SSc) is a chronic autoimmune disease characterised by excessive deposition of extracellular matrix (ECM) components, immune activation and neoangiogenesis. The pathogenesis of scleroderma is still poorly elucidated; however, an increasing burden of evidence suggests involvement of Toll-like Receptors (TLRs). In our working hypothesis, nucleic acid-containing immune complexes (ICs) isolated from scleroderma patients bearing different autoantibody antigenic specificities might activate TLRs, thus inducing several mediators involved in SSc pathogenesis. Therefore, the aim of this study was to characterise the role of TLR3 and TLR9 as potential mediators in the initiator phase of scleroderma. <h3>Materials and Methods</h3> Cutaneous fibroblasts were isolated from skin biopsies obtained from healthy donors and cultured in adequate conditions up to the eight passage. ICs were isolated using polyethylene glycol precipitation from sera of healthy controls and scleroderma patients carrying different autoantibody specificities (antibodies against centromere proteins [ACA], DNA topoisomerase I [ATA], RNA polymerase [ARA] and Th/To [anti-Th/To]). Levels of TLR3, TLR9, IFN-a and IFN-b mRNA expression in different experimental conditions were analysed by RT-PCR. Fibroblasts were transiently silenced for TLR3 using a specific small interfering RNA (siRNA); silencing was confirmed by RT-PCR and Western Blotting. TLR3-silenced and unsilenced cells were incubated with ICs of different sources or TLR agonists (poly(I:C) and LPS). Adhesion molecule (ICAM-1) expression was evaluated by cell-ELISA; interleukin (IL)-6 and IL-8 secretion in the supernatants was measured by commercial ELISA assays. <h3>Results</h3> In skin fibroblasts from healthy subjects, incubation with ICs isolated from SSc patients upregulated both TLR3 and TLR9 mRNA expression, with a higher increase in TLR9 levels. Consistently, a greater raise was observed for IFN-a than IFN-b mRNA expression levels. Both mRNA and protein TLR3 levels were significantly reduced by specific silencing. ICAM-1 expression was significantly increased in cells treated with both TLR agonists and ICs from SSc patients but not healthy controls. Similarly, IL-6 and IL-8 secretion was elevated in the same experimental conditions. TLR3 specific silencing significantly affected the production of ICAM-1, IL-6 and IL-8. <h3>Conclusions</h3> Our data suggest that activation of TLRs by ICs isolated from SSc patients leads to fibroblast activation, with upregulation of adhesion molecules and secretion of pro-inflammatory and pro-fibrotic interleukins. Further work is needed to better investigate the role of TLRs as potential pathogenetic mediators in SSc.
Doctors are failing to identify patients most at risk of killing, report says
Authors: Andrew Cole
Journal: BMJ (2006)

Clinicians are too often failing to identify the mentally ill patients most at risk of killing either themselves or someone else, a national inquiry into suicide and homicide has concluded. 

The report looked at suicides in England and Wales between 2000 and 2004 and homicides between 1999 and 2003. It found that mental health patients were responsible for 9% of homicides and made up 27% of all suicides. 

Half of the mental health patients who committed suicide and nearly a third of such patients who killed someone else had been in touch with mental health services within the previous week; yet 86% of …
Standard-Dose vs High-Dose Multivitamin Supplements for HIV—Reply
Authors: Sheila Isanaka, Ferdinand Mugusi, Wafaie W. Fawzi
Journal: JAMA (2013)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Hypereosinophilic syndrome: An update
Authors: H. Jeffrey Wilkins, Martin M. Crane, Kelly Copeland, William V. Williams
Journal: American Journal of Hematology (2005)

Abstract Hypereosinophilic syndrome (HES) is a rare disorder that is characterized by persistent and marked eosinophilia combined with organ system dysfunction. HES has substantial clinical heterogeneity but can be fatal without treatment, especially in patients who present with a myelodysplastic variant of the disorder. Although the pathophysiology of HES is poorly defined, dysregulation of cytokines (interleukin 5 [IL‐5], IL‐3, granulocyte‐macrophage colony‐stimulating factor [GM‐CSF]) responsible for the maturation of eosinophils is a primary feature. Of these cytokines, IL‐5 appears to have the greatest role in the regulation of eosinophil maturation. There is no Food and Drug Administration‐approved treatment for HES as yet; current strategies are designed to lower blood eosinophils and attempt to limit end‐organ damage. Historically, corticosteroids and cytotoxic agents have been the mainstays of therapy, with biological response modifiers such as interferon‐alpha also effective in some patients. However, despite improvements in survival, available agents have significant limitations in terms of efficacy, tolerability, and long‐term toxicity. More recently, new agents directed at specific targets in the pathogenesis of HES have been developed. These include imatinib mesylate, a tyrosine kinase inhibitor, and more recently, mepolizumab, an anti‐IL‐5 monoclonal antibody. In a small case series of patients, these agents have been shown to produce hematological and clinical responses in patients with HES, although they may be effective in different subsets of patients. These targeted therapies have the potential to improve clinical outcomes and to further the understanding the pathophysiology of this difficult‐to‐treat condition. Am. J. Hematol. 80:148–157, 2005. © 2005 Wiley‐Liss, Inc.
Smoking, cadmium, and emphysema
Authors: D J Hendrick
Journal: Thorax (2004)

A further step in the process of developing better service and standards of care for patients with COPD T he full version of the new NICE guidelines on the management of chronic obstructive pulmonary disease (COPD) is published as a supplement to this issue of Thorax. 1 These guidelines have been developed for the National Institute for Clinical Excellence (NICE) by the National Collaborating Centre for Chronic Conditions (NCC-CC) based at the Royal College of Physicians, London with the involvement of
Ultrasonographically Monitored Postocclusive Reactive Hyperemia in the Diagnosis of Peripheral Arterial Occlusive Disease
Authors: A. FRONEK, K. JOHANSEN, R. B. DILLEY, E. F. BERNSTEIN
Journal: Circulation (1973)

The femoral artery postocclusive reactive hyperemia response was monitored by transcutaneous Doppler ultrasonography. Normal values which were established from a group of 25 volunteers included a mean percentage increase [See Equation in PDF File] of 225.8% and a mean recovery half time of 25.2 secs. In a group of 22 patients with angiographically documented arterial occlusive disease, the respective mean values were 55.9% and 47.1 secs ( P &lt; .001). There was no statistically significant difference in the percentage velocity increases in repeat examinations. On the other hand, the recovery half time of the second postocclusive reactive hyperemia response was significantly shorter than the preceding one. The described technique proved to be very useful as a simple and objective procedure to screen and follow-up the development of arterial occlusive disease before and after reconstructive vascular surgery.
Effect of Valsalva's manoeuvre and hyoscinbutylbromide on the pressure gradient across the wall of oesophageal varices.
Authors: S W Hosking, P Robinson, A G Johnson
Journal: Gut (1987)

To assess whether Valsalva9s manoeuvre might cause variceal bleeding, 22 patients with oesophageal varices were studied. In 12 patients who received no previous treatment to their varices the median pressure gradient across the varix wall at rest was 19 (6-36) mmHg, and in 10 patients whose varices were thrombosed at their distal end the median pressure gradient in the proximal patent varix was 8 (1-6) mmHg. In untreated patients groups, the pressure gradient rose by 6-12 mmHg during Valsalva9s manoeuvre in four patients, fell by 4-11 mmHg in five patients and was virtually unchanged in the remainder. These changes seem unlikely to cause variceal bleeding. Patients who repeated Valsalva9s manoeuvre showed similar changes on each occasion. Six patients in the untreated group also received hyoscinbutylbromide 20 mg iv. No change was seen in the pressure gradient in five patients, suggesting that it is of little value in preventing variceal bleeding.
Excess Dosing of Antithrombotic Therapy in Non–ST-Segment Elevation Acute Coronary Syndromes
Authors: Frédéric Lapostolle, Jean Catineau, Claude Lapandry, Frédéric Adnet
Journal: JAMA (2006)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The Common Cold
Authors: George L. Fite
Journal: JAMA (1965)

These two treatises on the common cold, although separate in form, are related in many ways. They are designed to present the subject to quite different audiences. Tyrrell's approach is that of the scientific investigator of the disease in whose study he has been associated with Andrewes for many years. There are detailed references for each chapter, adequately documenting studies of each group of viruses capable of producing infection of the upper respiratory passages. Without becoming unduly technical, the researches of the past decade are presented understandably, yet in considerable detail. The physician is Tyrrell's intended reader, not the virologist. The volume appeals to the reader who would like to understand what virology is doing, where it is at the moment, and what lessons it has to offer. While there are few specific clinical directions, the physician is provided with the knowledge upon which he may build his own armamentarium
Controversial Saatchi bill passes report stage in House of Lords
Authors: C. Dyer
Journal: BMJ (2014)

The controversial Medical Innovation Bill, a private member’s bill aimed at protecting doctors who try new treatments from litigation, has had its report stage in the UK parliament and is likely to complete its progress in the House of Lords in the New Year.

The bill, put forward by the Conservative peer Maurice Saatchi, whose wife Josephine Hart died from ovarian cancer, is opposed by the BMA and other main medical groups, who have argued that it was unnecessary and could become a “quack’s charter.” More than 100 …
Abnormal systolic blood pressure response during exercise recovery in patients with angina pectoris
Authors: Masaki Hashimoto, Mitsunori Okamoto, Togo Yamagata, Tetsuya Yamane, Mitsumasa Watanabe, Yukiko Tsuchioka, Hideo Matsuura, Goro Kajiyama
Journal: Journal of the American College of Cardiology (1993)
RESEARCHES on VACCINIA and VARIOLA
Authors: M. A. Ruffer, H. G. Plimmer
Journal: BMJ (1894)

Ã r1'-4 -.Fig. 7.-Case ii, biliary cirrhosis; a, remains of lobule replaced by connective tissue; b, lobules infiltrated with fine connective tissue and cells becoming atrophied; c, more healtlly lobule, but even in this one there is fine connective tissue between the cells; d, ves- sel compressed by contracting new growth.A Zeiss oc. 3.
The Unintended Consequences of Measuring Quality on the Quality of Medical Care
Authors: L P Casalino
Journal: New England Journal of Medicine (1999)

It was midafternoon, and I was 30 minutes behind schedule. My next appointment was with a new patient, Mr. H., a 50-year-old man whose chief symptom was headaches. I spent more than the scheduled time with Mr. H., but the visit went well. I made a diagnosis of tension headaches, which he accepted after some explanation. As I put my hand on the doorknob to leave the room, now 40 minutes behind schedule (this wouldn't help my scores on surveys of patient and staff satisfaction), Mr. H. said, “Oh, by the way, sometimes I get a bit more short of . . .
Role of endothelin in the maintenance of blood pressure in conscious rats with chronic heart failure. Acute effects of the endothelin receptor antagonist Ro 47-0203 (bosentan).
Authors: J R Teerlink, B M Löffler, P Hess, J P Maire, M Clozel, J P Clozel
Journal: Circulation (1994)

Endothelin (ET) is a potent vasoconstrictor, and its concentration is increased in patients with heart failure. The purpose of this study was to investigate the role of endothelin in heart failure by use of a rat model.Experiments were performed on rats at 1 through 16 weeks after sham operation or coronary artery ligation. Rats with left ventricular end-diastolic pressures > 15 mm Hg were considered to have chronic heart failure (CHF), while the others were considered to have uncomplicated myocardial infarction (MI). There were increased ET-1 concentrations in CHF rats at weeks 1 to 16 (Sham, 20 +/- 0.5 pg/mL, n = 45; CHF, 31 +/- 2 pg/mL, n = 50; P < .001) and transient increases in ET-3 concentrations at week 1 in both the MI and CHF groups. There were no significant increases in big ET-1 concentrations, suggesting an increased conversion of ET-1 from big ET-1 in the CHF group. At weeks 2 through 8, oral administration of the mixed (ETA and ETB) endothelin receptor antagonist bosentan significantly decreased mean arterial pressure in conscious CHF rats, an effect that increased over time. Furthermore, bosentan had an additive effect to the angiotensin-converting enzyme inhibitor cilazapril.Endothelin plays a role in the maintenance of blood pressure in CHF rats, as evidenced by the significant reduction in mean arterial pressure after oral administration of bosentan. Therefore, endothelin antagonists may be useful therapeutic agents in the treatment of CHF.
Scintigraphic Detection of Retroperitoneal Bleeding Using Tc-99m Labeled Red Blood Cells
Authors: RUTH HARDOFF, SYLVIANNE BURSZTEIN DE MYTTENAERE
Journal: Clinical Nuclear Medicine (1991)

The use of Tc-99m labeled red blood cells in gastrointestinal bleeding is well documented. Recently, this modality has been used in detecting and localizing active bleeding in the pulmonary system, hepatobiliary system, and the peritoneal cavity. We describe a woman in whom scintigraphy revealed active bleeding into a retroperitoneal hematoma. While CT scanning accurately demonstrated the hematoma, scintigraphy was contributory in detecting the presence and the site of active bleeding.
Human hepatic regenerative stimulator substance: Partial purification and biological characterization of hepatic stimulator substance from human fetal liver cells
Authors: Yao Zhiqiang, Yang Weisong, Zhang Wenbin, Chen Yong, Yang Fengyi
Journal: Hepatology (1990)

Current support or replacement therapies for fulminant acute hepatic failure are frequently very disappointing. In this study, human hepatic stimulator substance--a liver-specific growth factor--was partially purified from human fetal liver cells and characterized by its biological effects. Almost 70-fold protein content was purified with an approximately 80-fold increase in specific growth stimulator activity. Human hepatic stimulator substance proved to be heat-stable, protease-sensitive, organ-specific and species-nonspecific. Human hepatic stimulator substance produced a two- to threefold increase of 3H-thymidine incorporation into hepatic DNA when injected intraperitoneally into growing weanling mice (nonhepatectomized) or regenerating rats (34% hepatectomy). The effects of hHSS in reversing the lethality of D-galactosamine (1.6 gm/kg body weight)-induced hepatic necrosis in rats were further evaluated. A survival rate of 4% (n = 24), 41% (n = 12, p less than 0.05), 33% (n = 12, p less than 0.05), 31% (n = 13, p less than 0.05) and 18% (n = 11, p greater than 0.05) was observed when the rats were injected with 4 ml of saline intraperitoneally, 4 ml of human intact fetal hepatocytes (2.4 x 10(8] intraperitoneally, 4 ml of human hepatic stimulator substance intraperitoneally, 2 ml of twofold concentrated human hepatic stimulator substance intravenously and 1 ml of fourfold human hepatic stimulator substance intramuscularly, respectively, 20 hr after poisoning.(ABSTRACT TRUNCATED AT 250 WORDS)