tbuckley/cabot-search huggingface dataset:
Lipid Peroxidation by Human Blood Phagocytes
Authors: Thomas P. Stossel, Robert J. Mason, Arnold L. Smith
Journal: Journal of Clinical Investigation (1974)

Cell suspensions enriched in human blood monocytes, obtained from normal peripheral blood by sedimentation on sodium diatrizoate-Ficoll gradients or from the blood of patients with neutropenia and monocytosis, accumulated malonyldialdehyde, a labile catabolite of lipid peroxidation, during incubations with polystyrene beads or heat-killed Staphylococcus epidermidis. Mixed blood leukocytes principally composed of granulocytes or granulocytes purified by density gradient sedimentation did not accumulate malonyldialdehyde during incubations with these particles, but did when ingesting particles containing linolenate. The phospholipid fatty acid composition of monocyte-enriched and purified granulocyte preparations from the same donors were compared. The molar fraction of arachidonate (20:4) in phospholipids from monocyte-rich preparations was 62% greater than that of purified granulocytes. The findings indicate that human monocytes, possibly because of a greater content of polyunsaturated fatty acids in their membranes, peroxidize a greater quantity of endogenous lipids than granulocytes during endocytosis. Normal human granulocytes have the capacity to peroxidize ingested lipids. However, mixed leukocytes from two patients with chronic granulomatous disease produced little malonyldialdehyde when engulfing linolenate-containing particles. Therefore the capacity to peroxidize lipid is related to cellular oxygen metabolism, a function in which chronic granulomatous disease granulocytes are dificient. Malonyldialdehyde chemically prepared by hydrolysis of tetramethoxypropane, by extraction from peroxidized linolenic acid, or purified from extracts of phagocytizing rabbit alveolar macrophages had bactericidal activity against Escherichia coli and S. epidermidis. Therefore, toxic catabolites of lipid hydroperoxides may potentiate the bactericidal activity of hydrogen peroxide in mononuclear phagocytes.
ALLERGIC CONTACT DERMATITIS TO GARLIC
Authors: E. BLEUMINK, H.M.G. DOEGLAS, A.H. KLOKKE, J. P. NATER
Journal: British Journal of Dermatology (1972)

Journal Article ALLERGIC CONTACT DERMATITIS TO GARLIC Get access E. BLEUMINK, E. BLEUMINK Department of Dermatology, State University, Groningen, The Netherlands Search for other works by this author on: Oxford Academic Google Scholar H.M.G. DOEGLAS, H.M.G. DOEGLAS Department of Dermatology, State University, Groningen, The Netherlands Search for other works by this author on: Oxford Academic Google Scholar A.H. KLOKKE, A.H. KLOKKE Department of Dermatology, State University, Groningen, The Netherlands Search for other works by this author on: Oxford Academic Google Scholar J. P. NATER J. P. NATER Department of Dermatology, State University, Groningen, The Netherlands Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 87, Issue 1, 1 July 1972, Pages 6–9, https://doi.org/10.1111/j.1365-2133.1972.tb05089.x Published: 01 July 1972 Article history Accepted: 11 February 1972 Published: 01 July 1972
906 FIXATION TEMPERATURE ALTERS INTRAMITOCHON-DRIAL CRYSTALS (IMC) IN HUMAN NASH: IMPLICATIONS FOR MITOCHONDRIAL CHANGES IN STEATOHEPATITIS
Authors: S.H. Caldwell, L.A.R. Freitas, S.H. Park, M.L.V. Moreno, C.A. Davis, J.A. Redick, J.T. Patrie, H.P. Cotrim, V.M.R. Lima, C.K. Argo, A.M. Al-Osaimi
Journal: Journal of Hepatology (2008)
1214 DOSE-RELATED INCREASE IN VIROLOGIC RESPONSES USING CONTROLLED RELEASE NITAZOXANIDE PLUS PEGINTERFERON ALFA-2A AND RIBAVIRIN FOR TREATMENT OF CHRONIC HEPATITIS C GENOTYPE 4: FINAL REPORT
Authors: E.B. Keeffe, A.A. Elfert, S.A. Abousaif
Journal: Journal of Hepatology (2011)
Interim estimates of the effectiveness of seasonal trivalent inactivated influenza vaccine in preventing influenza hospitalisations and primary care visits in Auckland, New Zealand, in 2014
Authors: N Turner, N Pierse, Q S Huang, S Radke, A Bissielo, M G Thompson, H Kelly, Collective on behalf of the SHIVERS investigation team
Journal: Eurosurveillance (2014)

We present preliminary results of influenza vaccine effectiveness (VE) in New Zealand using a case test-negative design for 28 April to 31 August 2014. VE adjusted for age and time of admission among all ages against severe acute respiratory illness hospital presentation due to laboratory-confirmed influenza was 54% (95% CI: 19 to 74) and specifically against A(H1N1)pdm09 was 65% (95% CI:33 to 81). For influenza-confirmed primary care visits, VE was 67% (95% CI: 48 to 79) overall and 73% (95% CI: 50 to 85) against A(H1N1)pdm09.
Impact of Patient Navigation on Timely Cancer Care: The Patient Navigation Research Program
Authors: Karen M. Freund, Tracy A. Battaglia, Elizabeth Calhoun, Julie S. Darnell, Donald J. Dudley, Kevin Fiscella, Martha L. Hare, Nancy LaVerda, Ji-Hyun Lee, Paul Levine, David M. Murray, Steven R. Patierno, Peter C. Raich, Richard G. Roetzheim, Melissa Simon, Frederick R. Snyder, Victoria Warren-Mears, Elizabeth M. Whitley, Paul Winters, Gregory S. Young, Electra D. Paskett
Journal: JNCI Journal of the National Cancer Institute (2014)

Patient navigation is a promising intervention to address cancer disparities but requires a multisite controlled trial to assess its effectiveness. The Patient Navigation Research Program compared patient navigation with usual care on time to diagnosis or treatment for participants with breast, cervical, colorectal, or prostate screening abnormalities and/or cancers between 2007 and 2010. Patient navigators developed individualized strategies to address barriers to care, with the focus on preventing delays in care. To assess timeliness of diagnostic resolution, we conducted a meta-analysis of center- and cancer-specific adjusted hazard ratios (aHRs) comparing patient navigation vs usual care. To assess initiation of cancer therapy, we calculated a single aHR, pooling data across all centers and cancer types. We conducted a metaregression to evaluate variability across centers. All statistical tests were two-sided. The 10521 participants with abnormal screening tests and 2105 with a cancer or precancer diagnosis were predominantly from racial/ethnic minority groups (73%) and publically insured (40%) or uninsured (31%). There was no benefit during the first 90 days of care, but a benefit of navigation was seen from 91 to 365 days for both diagnostic resolution (aHR = 1.51; 95% confidence interval [CI] = 1.23 to 1.84; P < .001)) and treatment initiation (aHR = 1.43; 95% CI = 1.10 to 1.86; P < .007). Metaregression revealed that navigation had its greatest benefits within centers with the greatest delays in follow-up under usual care. Patient navigation demonstrated a moderate benefit in improving timely cancer care. These results support adoption of patient navigation in settings that serve populations at risk of being lost to follow-up.
Pemphigus foliaceus IgG causes dissociation of desmoglein 1–containing junctions without blocking desmoglein 1 transinteraction
Authors: Jens Waschke, Paola Bruggeman, Werner Baumgartner, Detlef Zillikens, Detlev Drenckhahn
Journal: Journal of Clinical Investigation (2005)

Autoantibodies against the epidermal desmosomal cadherins desmoglein 1 (Dsg1) and Dsg3 have been shown to cause severe to lethal skin blistering clinically defined as pemphigus foliaceus (PF) and pemphigus vulgaris (PV). It is unknown whether antibody-induced dissociation of keratinocytes is caused by direct inhibition of Dsg1 transinteraction or by secondary cellular responses. Here we show in an in vitro system that IgGs purified from PF patient sera caused cellular dissociation of cultured human keratinocytes as well as significant release of Dsg1-coated microbeads attached to Dsg-containing sites on the keratinocyte cellular surface. However, cell dissociation and bead release induced by PF-IgGs was not caused by direct steric hindrance of Dsg1 transinteraction, as demonstrated by single molecule atomic force measurements and by laser trapping of surface-bound Dsg1-coated microbeads. Rather, our experiments strongly indicate that PF-IgG-mediated dissociation events must involve autoantibody-triggered cellular signaling pathways, resulting in destabilization of Dsg1-based adhesive sites and desmosomes.
Pseudo-Splenic Uptake in a DISIDA Scan
Authors: RAFAEL VAZQUEZ, ELIZABETH OATES, RICHARD HESLA
Journal: Clinical Nuclear Medicine (1987)

An 85-year-old man was admitted with right upper quadrant pain, jaundice, fever, and elevated liver function tests. As part of his work-up a Tc-99m disofenin scan was obtained revealing nonvisualization of the gallbladder, delayed excretion into the bowel at two hours, and an unusual anatomical variant of the left lobe of the liver simulating splenic uptake. Anatomical variants may sometimes represent diagnostic problems on imaging and their importance should therefore be recognized. In this case, due to the presence of partial common bile duct obstruction and delayed bowel visualization, the early images pointed to the possibility of unexplained splenic uptake or the inadvertent use of Tc-99m sulfur colloid instead of Tc-99m disofenin.
Oncogenic Tyrosine Kinase of Malignant Hemopathy Targets the Centrosome
Authors: Bénédicte Delaval, Sébastien Létard, Hélène Lelièvre, Véronique Chevrier, Laurent Daviet, Patrice Dubreuil, Daniel Birnbaum
Journal: Cancer Research (2005)

Abstract Myeloproliferative disorders (MPD) are malignant diseases of hematopoietic progenitor cells. Many MPDs result from a chromosomal translocation that creates a fusion gene encoding a chimeric kinase. The fibroblast growth factor receptor 1 (FGFR1)-MPD is characterized by the fusion of the FGFR1 kinase with various partners, including FOP. We show here that both normal FOP and FOP-FGFR1 fusion kinase localize to the centrosome. The fusion kinase encounters substrates at the centrosome where it induces strong phosphorylation on tyrosine residues. Treatment with FGFR1 kinase inhibitor SU5402 abolishes FOP-FGFR1-induced centrosomal phosphorylation and suppresses the proliferative and survival potentials of FOP-FGFR1 Ba/F3 cells. We further show that FOP-FGFR1 allows cells to overcome G1 arrest. Therefore, the FOP-FGFR1 fusion kinase targets the centrosome, activates signaling pathways at this organelle, and sustains continuous entry in the cell cycle. This could represent a potential new mechanism of oncogenic transformation occurring specifically at the centrosome.
Sickle Cell Disease Summit: From clinical and research disparity to action
Authors: Kathryn Hassell, Betty Pace, Winfred Wang, Roshni Kulkarni, Naomi Luban, Cage S. Johnson, James Eckman, Peter Lane, William G. Woods
Journal: American Journal of Hematology (2008)

The American Society of Pediatric Hematology/Oncology Sickle Cell Summit brought together a broad range of constituencies to identify a unified approach to healthcare and research disparities for sickle cell disease. Recommendations included the following: (1) speak with a unified voice representing all constituencies; (2) optimize access to care from knowledgeable health care providers and create a medical home for all individuals with the disease; (3) utilize population-based surveillance to measure outcomes; (4) develop overall approaches to basic, translational, clinical, and health services research; (5) enhance the community role in advocacy, education, service, and fundraising. Taskforces were identified to effect implementation.
Heterozygous ITGA2B R995W mutation inducing constitutive activation of the αIIbβ3 receptor affects proplatelet formation and causes congenital macrothrombocytopenia
Authors: Shinji Kunishima, Hirokazu Kashiwagi, Makoto Otsu, Naoya Takayama, Koji Eto, Masafumi Onodera, Yuji Miyajima, Yasushi Takamatsu, Junji Suzumiya, Kousaku Matsubara, Yoshiaki Tomiyama, Hidehiko Saito
Journal: Blood (2011)
Bristol Royal Infirmary. SECONDARY HAeMORRHAGE AFTER AMPUTATION
Authors: A. Prichard
Journal: BMJ (1855)

CASES of secondary hemorrhage after amputation give much anxiety to surgeons, and decisive measures are generally necessary to stop the bleeding.I mean, of course, to allude to hemorrhage following the separation of the ligatures, at the interval of a week, ten days, or a fortnight after the operation, when the stump is more or less healed, and not to the heemorrhage dependent upon insecure ligatures occurring within thirty-six hours of the operation.I do not believe, as has been asserted, that secondary he- morthage is more common after flap amputations than after operations by the circular incision.The mode of arresting the bleeding is determined partly by the degree to which union of the flaps has advanced,
High prevalance of TT virus infection in Japanese patients with liver diseases and in blood donors
Authors: Takanobu Kato, Masashi Mizokami, Etsuro Orito, Tatsunori Nakano, Yasuhito Tanaka, Ryuzo Ueda, Noboru Hirashima, Yoshihiko Iijima, Tetsuo Kato, Fuminaka Sugauchi, Motokazu Mukaide, Kazuhide Shimamatsu, Masayoshi Kage, Masamichi Kojiro
Journal: Journal of Hepatology (1999)
A Population Survey on the Prevalence of Diabetes in Kin-Hu, Kinmen
Authors: Pesus Chou, Ming-Jen Liao, Hsu-Sung Kuo, Kwang-Jen Hsiao, Shih-Tzer Tsai
Journal: Diabetes Care (1994)

To investigate the prevalence of non-insulin-dependent-diabetes mellitus in Kin-Hu, Kinmen.This is a community-based population survey. The target population are residents > or = 30 years of age in Kin-Hu, Kinmen, according to the official household registry in 1990. Face to face interviews were conducted by the Yang-Ming Crusade in 1991 using a structured questionnaire. Fasting blood samples were drawn by public health nurses, and a 75-g oral glucose tolerance test was performed for definite diagnosis of diabetes.There were 4,097 eligible subjects (2,026 men and 2,071 women), and 3,236 had complete fasting plasma glucose data (1,536 men and 1,700 women). The response rate was 79% (76% for men and 82% for women). The age-specific response rates were 81% for the 30- to 39-year and 50- to 59-year age-groups, 84% for the 40- to 49-year age-group, and 69% for the > or = 60-year age-group. The crude prevalence of diabetes in Kin-Hu was 6.5% (2.0% previous and 4.5% new). With the standard world population of Segi, the age-adjusted prevalence rate was 4.9% (4.5% for men and 5.4% for women). The prevalence rate of diabetes increased significantly with age. The prevalence of previously diagnosed diabetes accounted for less than one third of the total rate.The population survey in Kin-Hu, Kinmen, had a high response rate of 79%. The crude prevalence rate of diabetes was 6.5%, and the age-adjusted prevalence rate was 4.9%. The low ratio of previously diagnosed to newly diagnosed diabetic cases may be due to lack of public awareness and medical services in this community.
The Diagnosis of Aortic Septal Defect by Retrograde Aortography
Authors: BENJAMIN M. GASUL, EGBERT H. FELL, RAUL CASAS
Journal: Circulation (1951)

This rare congenital malformation is a round or oval opening between the ascending aorta and the main pulmonary artery above the semilunar valves. It is practically impossible to differentiate this malformation from a patent ductus arteriosus clinically because both malformations may present the same physical, fluoroscopic, roentgen and electrocardiographic findings. Even angiocardiography and cardiac catheterization do not differentiate these congenital malformations. The authors have studied 2 patients with aortic septal defects. One was operated at another clinic for a suspected patent ductus arteriosus, and the other case presented here was diagnosed by retrograde aortography.
795 REAL WORLD COSTS OF TELAPREVIR-BASED TRIPLE THERAPY, INCLUDING COSTS OF MANAGING ADVERSE EVENTS, AT THE MOUNT SINAI MEDICAL CENTER, NY: $147,000 PER EOT
Authors: K. Bichoupan, V. Martel-Laferriere, M. Ng, E.A. Schonfeld, A. Pappas, J. Crismale, A. Stivala, V. Khaitova, D. Gardenier, P. Perumalswami, T.D. Schiano, J.A. Odin, L. Liu, D.T. Dieterich, A.D. Branch
Journal: Journal of Hepatology (2013)
Successful umbilical cord blood transplantation for severe chronic active Epstein‐Barr virus infection after the double failure of hematopoietic stem cell transplantation
Authors: Masataka Ishimura, Shouichi Ohga, Akihiko Nomura, Taikai Toubo, Eiji Morihana, Yusuke Saito, Hisanori Nishio, Makoto Ide, Hidetoshi Takada, Toshiro Hara
Journal: American Journal of Hematology (2005)

Abstract An 11‐year‐old boy with severe chronic active Epstein‐Barr virus infection (CAEBV) underwent successful cord blood transplantation (CBT) after consecutive failure of peripheral blood and bone marrow transplantation from his HLA‐mismatched mother. CB cells from an unrelated donor were infused after conditioning with total body irradiation (12 Gy), melphalan (120 mg/m 2 ), and etoposide (600 mg/m 2 ). Complete remission without circulating EBV‐DNA has continued for 15 months after a delayed hematologic recovery. This is the first successful report of CBT for CAEBV. CB may therefore be an alternate source of stem cells for the curative treatment of CAEBV, despite the absence of EBV‐specific cytotoxic T lymphocytes. Am. J. Hematol. 80:207–212, 2005. © 2005 Wiley‐Liss, Inc.
Demonstration of Pleural Cerebrospinal Fluid Leak by ln-111 DTPA Radionuclide Myelogram
Authors: ANNE M. LARSON, MICHAEL M. GRAHAM
Journal: Clinical Nuclear Medicine (1992)

Subarachnoid pleural fistula is an uncommon complication of elective thoracotomy. Four weeks after left upper lobectomy with Tl-T3 hemilaminectomy for lung adenocarcinoma, a 47-year-old woman was admitted to the hospital for drainage from an unhealed postero-superior portion of the thoracotomy scar. Negative CT results made cerebrospinal fluid leak seem unlikely, and she underwent wound debridement and flap closure. In-1 11 DTPA radionuclide myelography was performed to study the acute onset of a large left pleural effusion and persistent wound drainage that occurred after wound closure. The accumulation of radiopharmaceutical in the left portion of the hemithorax revealed a large cerebrospinal fluid leak.
QUANTITATIVE ANTIBODY STUDIES IN MAN. I. THE EFFECT OF ADRENAL INSUFFICIENCY AND OF CORTISONE ON THE LEVEL OF CIRCULATING ANTIBODIES 1
Authors: Daniel L. Larson, Lois J. Tomlinson
Journal: Journal of Clinical Investigation (1951)

Investigators have for many years been interested in the relation of the adrenal gland to antibody formation. Observations made in animals have frequently led to conflicting results. The effect of adrenalectomy on antibody titres has been studied and has been shown to be associated with an elevation (1-3), a depression (4), and no change (5-8). The effect of ACTH or cortisone on antibody levels in the acute experiment has resulted in an elevation (1, 5, 9-11), no change (8, 12), and a depression (13). The effect of ACTH
Parkin Protects against the Toxicity Associated with Mutant α-Synuclein
Authors: Leonard Petrucelli, Casey O'Farrell, Paul J. Lockhart, Melisa Baptista, Kathryn Kehoe, Liselot Vink, Peter Choi, Benjamin Wolozin, Matthew Farrer, John Hardy, Mark R. Cookson
Journal: Neuron (2002)
Noncancer Deaths in White Adult Cancer Patients
Authors: B. W. Brown, C. Brauner, M. C. Minnotte
Journal: JNCI Journal of the National Cancer Institute (1993)

The cancer-specific death rate is a commonly used indicator in the assessment of progress against cancer. However, since the cause of death is often not substantiated and complete medical information is lacking, the validity of cancer-specific mortality rates is being questioned. Purpose : We investigated the validity of the cancer-specific death rate by examining noncancer deaths of cancer patients in a large patient population. Methods : Data were obtained from the National Cancer Institute's Surveillance, Epidemiology, and End Results (SEER) Program on cancer patients diagnosed between 1973 and 1987, with follow-up complete through December 1987. The SEER database consists of 1.2 million records from nine population-based registries covering nine geographic regions of the United States. Rates of noncancer deaths in the U.S. population were obtained from the National Center for Health Statistics. Cancer mortality rates were subtracted from overall mortality rates to obtain noncancer death rates by sex and the 5-year age group for each calendar year. Excluded from the study were patients of races other than White and those diagnosed at age 85 years or more due to absence of noncancer death rate comparisons. Also excluded were cancer cases discovered at autopsy and in persons less than 20 years of age. The statistical analysis employed a log-linear model. Results : The ratio of patient-to-general-population noncancer death rates, as calculated by dividing the number of patient noncancer deaths per year by the number found in the matched U.S. population data and referred to as the noncancer relative hazard, is considered significant with values greater than 1 for those with all cancers combined and for the common solid tumors examined. Of the 12 leading causes of death other than cancer in the patient population, the most common causes were circulatory and respiratory failures. The noncancer relative risk of death decreased rapidly after diagnosis and also decreased with the patient's age at diagnosis. It increased slightly with the calendar year of diagnosis. Conclusions : Because more noncancer deaths occurred shortly after diagnosis, it appears that this excess was caused by treatment of the cancer. Generally, cancer-specific death rates underestimate the mortality associated with a diagnosis of cancer. Therefore, because the degree of underestimation changes with time, an examination solely of cancer-caused mortality in assessing progress against the disease is incomplete. (J Natl Cancer Inst 85: 979-987, 1993)
The Battered Child
Authors: Clement A. Smith
Journal: New England Journal of Medicine (1973)

The April, 1973, issue of Pediatrics included as a 40-page supplement the proceedings of a Symposium on Child Abuse, sponsored by the Medical Society of the County of New York. Since the syndrome is a disease not of children but of adults and indeed of Society, the subject warrants the concern of all professionals who administer health care.Such abuse in one form or another is an old and sad story beginning in pre-history with infanticide. Child neglect and the child labor of an increasingly industrial society resulted in the founding of the Society for the Prevention of Cruelty to . . .
CHLORPROMAZINE: ALONE AND AS AN ADJUNCT TO GROUP PSYCHOTHERAPY IN THE TREATMENT OF PSYCHIATRIC PATIENTS
Authors: RICHARD C. COWDEN, M. ZAX, J. ROSS HAGUE, R. C. FINNEY
Journal: American Journal of Psychiatry (1956)

Eight schizophrenic patients received chlorpromazine and group psychotherapy, 8 received only chlorpromazine, and 7 patients acted as control. The two groups receiving the drug improved significantly more than the control in practically all measures. The 8 patients receiving group therapy in addition to the drug showed greater improvement than the drug-only group. Chlorpromazine is an effective adjunct to other therapies when used properly. It is not effective with all types of patients.