tbuckley/cabot-search huggingface dataset:
Pregnancy and Sinus Histiocytosis with Massive Lymphadenopathy
Authors: WILLIAM M. BUTLER
Journal: Annals of Internal Medicine (1985)

Letters and Corrections1 February 1985Pregnancy and Sinus Histiocytosis with Massive LymphadenopathyWILLIAM M. BUTLER, M.D., WILLIAM A. ARMSTRONG, M.D.WILLIAM M. BUTLER, M.D., WILLIAM A. ARMSTRONG, M.D.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-102-2-278 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: Sinus histiocytosis with massive lymphadenopathy was described as a clinical entity by Rosai and Dorfman (1) in 1969. This disease is usually self-limited and occurs in the first 20 years of life. It is characterized by prominent adenopathy, fever, leukocytosis, anemia, and hypergammaglobulinemia. The extranodal involvement usually involves the orbit, eyelid, upper respiratory tract, or skin (2).We have recently seen a 18-year-old black woman who presented in March 1981 with sinus histiocytosis with massive lymphadenopathy. She developed a hyperviscosity syndrome in June 1981 (3). Prominent orbital swelling prompted a biopsy in October 1981, which showed involvement...References1. ROSAIDORFMAN JR. Sinus histiocytosis with massive lymphadenopathy: a newly recognized benign clinicopathological entity. Arch Pathol. 1969;87:63-70. MedlineGoogle Scholar2. ROSAIDORFMAN JR. Sinus histiocytosis with massive lymphadenopathy: a pseudolymphomatous benign disorder. Cancer. 1972;30:1174-88. CrossrefMedlineGoogle Scholar3. BUTLERPUCKETTMCFARLAND WJJ. Sinus histiocytosis with massive lymphadenopathy complicated by a hyperviscosity syndrome. Plasma Ther Transfusion Technol. 1983;3:442-3. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Richland Medical Park, Suite 505, 3321 Medical Park Road; Columbia, SC 29203 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByPregnant patient with extranodal CNS Rosai-Dorfman disease with new-onset seizures: the conundrum of differentiating disease progression from eclampsiaIsolated Langerhans Cell Histiocytosis of the Vulva: A Case ReportSinus histiocytosis with massive lymphadenopathy (Destombes-Rosai-Dorfman syndrome) occurring as a single enlarged submandibular lymph node: A light and immunohistochemical study with review of the literature 1 February 1985Volume 102, Issue 2Page: 278-278KeywordsAnemiaBiopsyFeversHypergammaglobulinemiaInflammationLeukocytosisPregnancyRespiratory system Issue Published: 1 February 1985 PDF DownloadLoading ...
Relation of Alpha-Fetoprotein in Acute Hepatitis to Severity and Prognosis
Authors: GERASIMOS G. KARVOUNTZIS
Journal: Annals of Internal Medicine (1974)

Serums of 104 patients with acute hepatitis of variable severity were tested for alpha-fetoprotein by counterelectrophoresis. Among 51 patients with fulminant hepatitis and coma, alpha-fetoprotein was detected in 17 (85%) of 20 who survived and in only 12 (38.7%) of 31 fatal cases (P = 0.002, Fisher's exact test). Among 53 patients without coma, alpha-fetoprotein was detected in 16. Alpha-fetoprotein positivity was found to be related to the severity of the disease, and its appearance was followed by recovery in these patients. The high levels of alpha-fetoprotein observed in severe forms of hepatitis may represent active hepatocyte regeneration after extensive hepatic necrosis. Moreover, the presence of alpha-fetoprotein seems to be a favorable prognostic sign.
[102] RELATIVE CONTRIBUTION OF CYCLOOXYGENASE-2 AND 5-LIPOXYGENASE PATHWAYS TO LIVER INFLAMMATION AND FIBROSIS
Authors: R. Horrillo, A. Planaguma, A. Gonzalez-Periz, N. Ferre, E. Titos, R. Miquel, M. Lopez-Parra, I.E. Masferrer, V. Arroyo Rodes, J. Claria
Journal: Journal of Hepatology (2007)
Noncardiac Surgery in the Cardiac Patient: What Is the Question?
Authors: Monty M. Bodenheimer
Journal: Annals of Internal Medicine (1996)

Before having major noncardiac surgery, patients with known or suspected coronary artery disease frequently have noninvasive cardiac testing to better define their cardiac risk.The rationale for this approach is that prophylactic coronary revascularization will significantly reduce the number of adverse cardiac events. No randomized studies support this conclusion. Furthermore, recent studies have suggested that adverse cardiac events result from postoperative stress and excess catecholamine levels, which cause an imbalance between myocardial oxygen supply and demand. Plaque rupture in this setting, if it occurs, is secondary and not primary, in contrast to its pivotal role in spontaneous myocardial infarction. Therefore, improved clinical outcomes are more likely to result from preventing excess oxygen demand after surgery rather than from deciding which tests optimally predict adverse events. The exception is the patient with a clinical syndrome consistent with existing plaque rupture who requires active therapy for the cardiac disease independent of the need for noncardiac surgery. Otherwise, the tests should be skipped and the patient cleared.
Case 2-1963
Authors: Richard C. Cabot, Benjamin Castleman, Betty U. Kibbee
Journal: New England Journal of Medicine (1963)

Presentation of Case A forty-eight-year-old unemployed man was referred to the hospital because of jaundice and gastrointestinal bleeding. Two weeks before entry the patient became severely anorectic and was told that his complexion appeared yellow. The anorexia persisted, and the jaundice deepened; there were no chills, fever, abdominal pain or fatty-food intolerance. He became progressively weak and drowsy. On the day of entry he vomited a large amount of liquid and clotted blood and passed several maroon-colored stools. The patient's mother had been treated for syphilis during his childhood, and he had previously been treated with penicillin at another hospital. . . .
THE PATHOLOGY OF PEPTIC ULCER OF THE STOMACH
Authors: HOWARD T. KARSNER
Journal: JAMA (1925)

This review will be confined to a consideration of the peptic ulcer, round ulcer or simple gastric ulcer, and will omit that interesting group of acute ulcers, all discussed by Schultze,<sup>1</sup>which occur in acute infectious disease or which result from passive hyperemia with petechiae, from erosion by foreign bodies and other causes, and which tend to heal rapidly and leave no serious after-effects. The peptic ulcer is acute in its early stages but is peculiar in that it tends to persist and become chronic, heals slowly if at all, and may exhibit several dangerous complications and sequels. <h3>GROSS MORBID ANATOMY</h3> The peptic ulcer is usually a single, round or oval, sometimes distinctly elongated elliptic ulcer, situated in the posterior wall of the pyloric portion of the stomach near the lesser curvature. Except in the earliest stages, the ulcer is deep, may show a "punched out" appearance, may be
Cholecysto-pancreatitis due to Ascaris lumbricoides
Authors: E. Zapata, L. Zubiaurre, P. Salvador, A. Castiella, L. Alzate, P. López, J. Arriola, F. Múgika
Journal: Endoscopy (2007)

Parasitic infestations of the hepatic biliary tree most commonly involve Ascaris lumbricoides, which infects an estimated 25 % of the world’s population [1]. These infections are increasing in the developed countries due to world travel and population migrations. Individuals may be asymptomatic. When symptoms occur, they include pulmonary and hypersensitivity manifestations, and intestinal, hepatobiliary, and pancreatic symptoms [2]. Migration of adult worms into the biliary tree can cause abdominal pain, biliary colic, cholangitis, obstructive jaundice, strictures, hepatic abscesses, and pancreatitis. The diagnosis is made by identifying the egg or an adult worm in bile or feces, and it can be confirmed by ultrasonography or endoscopic retrograde cholangiopancreatography (ERCP). The typical ultrasound finding is linear, parallel echogenic structures with no acoustic shadowing, or non-shadowing echogenic strips with a central anechoic tube. ERCP is a highly sensitive method of demonstrating the worm in the biliary and pancreatic ducts [3]. When worms protrude out of the papilla, a grasping forceps can be used to hold them; when they are entirely within the bile duct, they can be stimulated to migrate out after contrast injection, or can be extracted using a basket or occlusion balloon. Patients should be treated with antihelminthic therapy to eradicate remaining worms [4].
Mac-1 (CD11b/CD18) Links Inflammation and Thrombosis After Glomerular Injury
Authors: Junichi Hirahashi, Keiichi Hishikawa, Shinya Kaname, Naotake Tsuboi, Yunmei Wang, Daniel I. Simon, George Stavrakis, Tatsuo Shimosawa, Ling Xiao, Yutaka Nagahama, Kazuo Suzuki, Toshiro Fujita, Tanya N. Mayadas
Journal: Circulation (2009)

Inflammation and thrombosis coexist in several disorders. Although it is recognized that leukocytes may induce a procoagulant state at sites of inflammation, the critical molecular determinants of this process remain largely unknown.
The Smiths
Authors: Thomas B. Cole
Journal: JAMA (2014)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
GW25-e5252 Inhibitory Effects of Dronedarone on Small Conductance Calcium Activated Potassium Channels in Patients with Chronic Atrial Fibrillation: Comparison to Amiodarone
Authors: Li Miaoling, Huan Lan, Tao Li, Xianhong Ou, Guilan Chen, Yan Yang, Xiaorong Zeng
Journal: Journal of the American College of Cardiology (2014)
Unanswered Questions About DNR Orders
Authors: Bernard Lo
Journal: JAMA (1991)

Everyone who dies suffers a cardiac arrest. Cardiopulmonary resuscitation (CPR) can revive patients after they experience unexpected cardiac arrests and restore them to vigorous health. But for persons with progressive chronic illness, CPR is more likely to prolong death than prevent it. The thoughtful guidelines promulgated by the American Medical Association (AMA) concerning do-not-resuscitate (DNR) orders<sup>1</sup>deserve careful reading by all physicians, but they do not address several important questions. Furthermore, on some issues, reasonable physicians will disagree, perhaps intensely. <h3>When Is CPR Futile?</h3> It is irrational to provide CPR when it would be futile. But while this general rule seems obvious, it may be difficult to decide, in particular cases, whether CPR would be "futile." The term<i>futile</i>is used in many different ways.<sup>2</sup>In a strict sense, treatment is futile when it offers no benefit to the patient, because maximal therapy has failed and physiologic improvement is
Acute epiglottiditis requiring tracheostomy in an adult.
Authors: B D Linaker
Journal: BMJ (1976)

50 mg twice daily was started in April 1976 after urine sterilisation.No side effects were noted, and his renal function remained normal.However, 10 weeks later he developed crystalluria, with small irregular bright purple crystals, despite an excellent fluid intake.After two days the crystals blocked his Silastic urinary catheter and he required repeated bladder lavage.Nitrofurantoin, his only medication during the 10 weeks, was stopped, and the crystalluria disappeared within four days.Analysis showed a sterile urine with acidity 12 x 103 nmol/l (pH 4-9).The crystals showed solubilities typical of nitrofurantoin, and ultraviolet spectrophotometry2 identified substantial quantities of nitrofurantoin in the crystals, with calcium and magnesium also present.
Regulations not keeping up with developments in genetics, says poll
Authors: P. Brown
Journal: BMJ (2000)

A major UK public consultation on the future uses of genetic information began this week, as interim results from a survey showed that many people fear the misuse of genetic data by insurers, employers, and industry scientists.

The consultation was launched by the Human Genetics Commission, the body set up by the UK government in 1999 to advise ministers on developments in genetics that affect health and society. The commission's discussion document summarises the current status of the use of genetic data for medical, research, employment, insurance, and forensic purposes in the United Kingdom and seeks readers' responses by next February. A draft report will appear next June.

Baroness …
Absence of Fc epsilonRI alpha chain results in upregulation of Fc gammaRIII-dependent mast cell degranulation and anaphylaxis. Evidence of competition between Fc epsilonRI and Fc gammaRIII for limiting amounts of FcR beta and gamma chains.
Authors: D Dombrowicz, V Flamand, I Miyajima, J V Ravetch, S J Galli, J P Kinet
Journal: Journal of Clinical Investigation (1997)

In mouse mast cells, both Fc epsilonRI and Fc gammaRIII are alpha beta gamma2 tetrameric complexes in which different alpha chains confer IgE or IgG ligand recognition while the signaling FcR beta and gamma chains are identical. We used primarily noninvasive techniques (changes in body temperature, dye extravasation) to assess systemic anaphylactic responses in nonanesthetized wild-type, Fc epsilonRI alpha chain -/- and FcR gamma chain -/- mice. We confirm that systemic anaphylaxis in mice can be mediated largely through IgG1 and Fc gammaRIII and we provide direct evidence that these responses reflect activation of Fc gammaRIII rather than Fc gammaRI. Furthermore, we show that Fc gammaRIII-dependent responses are more intense in normal than in congenic mast cell-deficient KitW/KitW-v mice, indicating that Fc gammaRIII responses have mast cell-dependent and -independent components. Finally, we demonstrate that the upregulation of cell surface expression of Fc gammaRIII seen in Fc epsilonRI alpha chain -/- mice corresponds to an increased association of Fc gammaRIII alpha chains with FcR beta and gamma chains and is associated with enhanced Fc gammaRIII-dependent mast cell degranulation and systemic anaphylactic responses. Therefore, the phenotype of the Fc epsilonRI alpha chain -/- mice suggests that expression of Fc epsilonRI and Fc gammaRIII is limited by availability of the FcR beta and gamma chains and that, in normal mice, changes in the expression of one receptor (Fc epsilonRI) may influence the expression of functional responses dependent on the other (Fc gammaRIII).
Survival rate of antitumour necrosis factor-α treatments for psoriasis in routine dermatological practice: a multicentre observational study
Authors: M. Esposito, P. Gisondi, N. Cassano, G. Ferrucci, M. Del Giglio, F. Loconsole, A. Giunta, G.A. Vena, S. Chimenti, G. Girolomoni
Journal: British Journal of Dermatology (2013)

Adherence is an overall marker of treatment success, and it depends on multiple factors including efficacy and safety. Despite the wide use of tumour necrosis factor (TNF)-α blockers in the treatment of plaque-type psoriasis, few data regarding treatment adherence in routine clinical practice are available.To estimate the long-term survival rate of anti-TNF-α therapy in a cohort of patients with psoriasis in routine clinical practice; to evaluate the reasons for and predictors of treatment discontinuation.The Outcome and Survival rate Concerning Anti-TNF Routine treatment (OSCAR) study was based on a retrospective analysis to estimate the long-term survival rate of the first anti-TNF-α treatment in patients with psoriasis, from three Italian academic referral centres. Adult patients (n = 650) with plaque psoriasis treated with a first course of adalimumab, etanercept or infliximab for ≥ 3 months were included.Global adherence to anti-TNF-α treatments after 28·9 ± 15·4 months (867 ± 462 days) of observation was 72·6%. Etanercept showed a longer survival (mean 51·4 months, 1565 days; P < 0·001) compared with infliximab (36·8 months, 1120 days) and adalimumab (34·7 months, 1056 days). Treatment discontinuation due to primary and secondary inefficacy was observed in 5·2% and 14·5% of patients, respectively, whereas discontinuation due to adverse events was reported in 29 subjects (4·5%). Independent predictors of treatment withdrawal were female gender [hazards ratio (HR) 1·3], treatment with adalimumab or infliximab compared with etanercept (HR 2·7 and 1·7, respectively), and the concomitant use of traditional systemic treatment, as a rescue therapy, compared with monotherapy (HR 1·9).Overall survival of anti-TNF-α agents in psoriasis is elevated, with drug discontinuation mostly due to inefficacy. Etanercept showed a longer adherence compared with adalimumab and infliximab.
The neuropathic potential of anti-GM1 autoantibodies is regulated by the local glycolipid environment in mice
Authors: Kay N. Greenshields, Susan K. Halstead, Femke M.P. Zitman, Simon Rinaldi, Kathryn M. Brennan, Colin O’Leary, Luke H. Chamberlain, Alistair Easton, Jennifer Roxburgh, John Pediani, Koichi Furukawa, Keiko Furukawa, Carl S. Goodyear, Jaap J. Plomp, Hugh J. Willison
Journal: Journal of Clinical Investigation (2009)

Anti-GM1 ganglioside autoantibodies are used as diagnostic markers for motor axonal peripheral neuropathies and are believed to be the primary mediators of such diseases. However, their ability to bind and exert pathogenic effects at neuronal membranes is highly inconsistent. Using human and mouse monoclonal anti-GM1 antibodies to probe the GM1-rich motor nerve terminal membrane in mice, we here show that the antigenic oligosaccharide of GM1 in the live plasma membrane is cryptic, hidden on surface domains that become buried for a proportion of anti-GM1 antibodies due to a masking effect of neighboring gangliosides. The cryptic GM1 binding domain was exposed by sialidase treatment that liberated sialic acid from masking gangliosides including GD1a or by disruption of the live membrane by freezing or fixation. This cryptic behavior was also recapitulated in solid-phase immunoassays. These data show that certain anti-GM1 antibodies exert potent complement activation-mediated neuropathogenic effects, including morphological damage at living terminal motor axons, leading to a block of synaptic transmission. This occurred only when GM1 was topologically available for antibody binding, but not when GM1 was cryptic. This revised understanding of the complexities in ganglioside membrane topology provides a mechanistic account for wide variations in the neuropathic potential of anti-GM1 antibodies.
Restoring Balance to Industry-Academia Relationships in an Era of Institutional Financial Conflicts of Interest
Authors: Michael M. E. Johns, Mark Barnes, Patrik S. Florencio
Journal: JAMA (2003)

Economic partnerships between industry and academia accelerate medical innovation and enhance patient access to medical advances, but such partnerships have sometimes eroded public trust in the research enterprise. There is particular risk for conflict of interest when economic partnerships extend beyond a university's corporate interests to involve institutional decision makers. Institutions and institutional decision makers should fully disclose industry-related financial interests and relationships. Without legitimate justification for such interests, individuals should divest themselves from these interests or recuse themselves from responsibility for research oversight. Management of institutional partnerships also might entail the physical separation of certain facilities, the placement of restrictions on information shared between investment and research staffs, and provision of oversight by independent review panels made up of persons who have expertise in intellectual property, finance, and research, but who are not financially or otherwise dependent on the institution. Through these means, it is possible to restore balance to industry-academia relationships, thereby promoting progress while maintaining public trust in research.
Switching from 0- to 2-hour ciclosporin monitoring lowers dose, improves kidney function but not blood pressure although C-2 poorly reflects ciclosporin area under the curve
Authors: P. Langers, R. ten Hove, R. Veenendaal, J. Ringers, C.B.H.W. Lamers, B. van Hoek
Journal: Journal of Hepatology (2003)
Screening for carriers of cystic fibrosis.
Authors: J C Dean, K F Kelly, Z Miedzybrodzka, A E Shrimpton
Journal: BMJ (1991)

out in the more conducive environment of NHS facilities.We have serious doubts regarding the viability of the scrutiny team's proposals; in particular we believe that the purchasers (the prison service) will not be able to find adequate providers (NHS doctors).A corps of part time doctors devoted to the service already exists, but experience tells us that few others are likely to last the course.
Nitric Oxide Inhibits α <sub>2</sub> -Adrenoceptor–Mediated Endothelium-Dependent Vasodilation
Authors: Eric Thorin, Paul L. Huang, Mark C. Fishman, John A. Bevan
Journal: Circulation Research (1998)

This study was designed to investigate the interaction between the NO/L-arginine pathway and the alpha2-adrenoceptor-mediated endothelium-dependent vasorelaxation. Reactivity of isolated resistance mesenteric arterial segments from mice lacking the gene for constitutive endothelial NO synthase (eNOS- mice, n=14) and from their wild-type controls (WT mice, n=46) was studied in isometric conditions in the presence of indomethacin (blocker of cyclooxygenase). Oxymetazoline (OXY, 0.01 to 30 micromol/L; a selective alpha2-adrenoceptor agonist) induced an endothelium-dependent relaxation of eNOS- but not WT arteries preconstricted either with phenylephrine or serotonin. In the presence of Nomega-nitro-L-arginine (l-NNA, 100 micromol/L), an inhibitor of NOS, OXY induced an endothelium-dependent relaxation of WT mesenteric arteries. l-NNA had no effect on the relaxation caused by OXY in eNOS- arterial rings. Therefore, the relaxation caused by OXY was independent of NO formation. To demonstrate the inhibitory role of NO on the alpha2-adrenoceptor-mediated relaxation, subthreshold (0.1 nmol/L) to threshold (1 nmol/L) concentrations of sodium nitroprusside (donor of NO) were added to l-NNA-treated arteries before OXY challenges: in these conditions, the alpha2-adrenoceptor-mediated relaxation of eNOS- and WT arteries was inhibited. OXY-induced relaxation was restored on readdition of methylene blue (1 micromol/L, inhibitor of guanylate cyclase), suggesting that cGMP may be the mechanism of inhibition of the alpha2-adrenergic pathway in the presence of NO. Finally, OXY-mediated relaxation was blocked by tetraethylammonium (1 mmol/L) but not glibenclamide (1 micromol/L), suggesting the involvement of an endothelium-derived hyperpolarizing factor that activates Ca2+-activated K+ channels. In conclusion, alpha2-adrenoceptor activation caused relaxation of isolated murine mesenteric arteries that was functionally blocked by NO through a mechanism that may involve activation of the soluble guanylate cyclase and cGMP formation. The endothelium-dependent alpha2-adrenoceptor-mediated relaxation is likely to be due to an endothelium-derived hyperpolarizing factor, whose release and/or production is reduced by concurrent NO formation.