A CASE OF FULMINATING MENINGOCOCCEMIA EXHIBITING THE WATERHOUSE-FRIDERICHSEN SYNDROME AND DEMONSTRATING THE VALUE OF CORTICAL EXTRACT ADMINISTRATION
Authors: H A GRUBSCHMIDT, G C GRAHAM, E C JESSUP
Journal: Annals of Internal Medicine (1947)

Case Reports1 February 1947A CASE OF FULMINATING MENINGOCOCCEMIA EXHIBITING THE WATERHOUSE-FRIDERICHSEN SYNDROME AND DEMONSTRATING THE VALUE OF CORTICAL EXTRACT ADMINISTRATIONH. A. GRUBSCHMIDT, M.D., G. C. GRAHAM, M.D., E. C. JESSUP, M.D., F.A.C.P.H. A. GRUBSCHMIDT, M.D.Search for more papers by this author, G. C. GRAHAM, M.D.Search for more papers by this author, E. C. JESSUP, M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-26-2-294 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptPratt-Thomas in 19456 reviewed 184 cases of fulminating meningococcemia with eight recoveries. Prior to 1940, all cases were uniformly fatal.This is a case of Waterhouse-Friderichsen syndrome in a 17 year old white female who fulfilled practically all the clinical criteria and, in addition, yielded meningococci on blood culture. She developed gangrene of three extremities and bilateral ulnar nerve paralysis but recovered. The case presents several unusual features.CASE REPORTThe patient was a 17 year old white female waitress who entered Meadowbrook Hospital on Oct. 12, 1945, with a chief complaint of chills and fever of several hours' duration....Bibliography1. CUTLERPOWERWELDER HPMHRM: Concentrations of chloride, sodium, potassium in urine and blood: Their diagnostic significance in adrenal insufficiency, Jr. Am. Med. Assoc., 1938, cxi, 117-122. CrossrefGoogle Scholar2. D'AGATIMARANGONI VCBA: The Waterhouse-Friderichsen syndrome, New Eng. Jr. Med., 1944, ccxxxii, 1. Google Scholar3. GOLDZIEHR MA: The adrenal glands in health and disease, 1944, F. A. Davis & Co. Google Scholar4. HAYESWHALEN JMJF: Fulminating meningococcemia (Waterhouse-Friderichsen syndrome). An unusual case with recovery following treatment with penicillin, Jr. Am. Med. Assoc., 1945, cxxvii, 645. CrossrefGoogle Scholar5. LOEBATCHLEYBENEDICTLELAND RFDWEMJ: Electrolyte balance studies in adrenalectomized dogs with particular reference to excretion of sodium, Jr. Exper. Med., 1933, lvii, 775-792. CrossrefGoogle Scholar6. PRATT-THOMASKELLEYGAZES HRWHPC: Fulminating meningococcemia, South. Med. Jr., 1945, xxxviii, 229. CrossrefGoogle Scholar7. RUCKSHOBSEN WLJJ: Purpura fulminans (Waterhouse-Friderichsen syndrome), case report, Memphis Med. Jr., 1944, xix, 18. Google Scholar8. WEINBERGMCGAVACK LDTH: The Waterhouse-Friderichsen syndrome, New England Jr. Med., 1945, ccxxxii, 95. CrossrefGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Hempstead, New York*Received for publication March 16, 1946.From Meadowbrook Hospital. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byHerz- und Kreislaufstörungen bei InfektionskrankheitenHerz- und Kreislaufstörungen bei InfektionskrankheitenNor-Epinephrine in the Treatment of Acute Meningococcemia with Shock (Waterhouse-Friderichsen Syndrome) and an Evaluation of Adrenocortical FunctionFulminating meningococcemia with gangrene 1 February 1947Volume 26, Issue 2Page: 294-304KeywordsBloodFeversMeningococcemiaNervesParalysis ePublished: 1 December 2008 Issue Published: 1 February 1947 PDF downloadLoading ...