Sea-Blue Histiocytes in Thrombocytopenic Purpura
Authors: Pradeep Chandra, Fred Rosner, Arthur Sawitsky
Journal: Annals of Internal Medicine (1973)

Letters1 December 1973Sea-Blue Histiocytes in Thrombocytopenic PurpuraPRADEEP CHANDRA, M.D., FRED ROSNER, M.D., F.A.C.P., ARTHUR SAWITSKY, M.D., F.A.C.P.PRADEEP CHANDRA, M.D.Search for more papers by this author, FRED ROSNER, M.D., F.A.C.P.Search for more papers by this author, ARTHUR SAWITSKY, M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-79-6-901 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: Sea-blue histiocytes have been found in the bone marrow of patients with the hereditary syndrome (1), as well as that of patients with other disorders—chronic granulocytic leukemia (2), polycythemia vera (3), erythremic myelosis (4), sickle-cell disease (5), hypochromic anemia (3), Hurler's syndrome (3), rheumatoid arthritis (3), Hodgkin's disease* and multiple myeloma*—and even in two of 14 healthy rabbits (6). We have recently seen a patient with autoimmune thrombocytopenic purpura who had sea-blue histiocytes in her marrow aspirate when her platelet count was 3000/mm3; these histiocytes were not seen when the disease was in remission.A 22-year old...References1. SAWITSKYROSNERCHODSKY AFS: The sea-blue histiocyte syndrome, a review: genetic and biochemical studies. Semin Hematol 9:285-297, 1972 MedlineGoogle Scholar2. DOSIKROSNERSAWITSKY HFA: Acquired lipidosis: Gaucher-like cells and "blue cells" in chronic granulocytic leukemia. Semin Hematol 9:309-316, 1972 MedlineGoogle Scholar3. SUNDBERGNELSONHOILUND RDL:Cell debris and blue pigment macrophages in chronic myelogenous leukemia. Abstract A:37 of Program of the Tenth Congress of The International Society of Hematology, Stockholm, August and September, 1964 Google Scholar4. KARAYALCINROSNERSAWITSKY GFA: Sea-blue histiocyte syndrome in an octagenarian (letter). Lancet 2:318, 1971 CrossrefMedlineGoogle Scholar5. KATTLOVEGAYNORSPIVACK HEM:Sea-blue indigestion. N Engl J Med 282:630-631, 1970 CrossrefMedlineGoogle Scholar6. SAWITSKYROSNER AF: Sea-blue histiocytes in a rabbit (letter). Lancet 2:933, 1971 CrossrefMedlineGoogle Scholar7. RYWLINHERNANDEZCHASTAIN AJD:Ceroid histiocytosis of spleen and bone marrow in idiopathic thrombocytopenic purpura: a contribution to the understanding of the sea-blue histiocyte. Blood 37:587-593, 1971 CrossrefMedlineGoogle Scholar8. CZERNOBILSKYFREEDMANFRUMIN BHA: Foamy histiocytes in spleens removed for chronic idiopathic thrombocytopenic purpura. Blood 19:99-108, 1962 CrossrefMedlineGoogle Scholar9. DOLLBERGCASPERDJALDETTI LJM:Lipid-laden histiocytes in the spleen in thrombocytopenic purpura. Am J Clin Pathol 43:16-25, 1965 CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Queens Hospital Center Affiliation Long Island Jewish-Hillside Medical Center Jamaica, New York*Sawitsky A. Rosner F: Unpublished observations. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byThe Pathology of the SpleenSea-Blue Histiocyte Syndrome in Bone Marrow Secondary to Total Parenteral NutritionVery low levels of high density lipoprotein cholesterol in four sibs of a family with non-neuropathic Niemann-Pick disease and sea-blue histiocytosis.Association of Splenoma, Peliosis and Lipid Histiocytosis in Spleen or Accessory Spleen Removed in 2 Patients with Chronic Idiopathic Thrombocytopenic Purpura after Long Term Treatment with SteroidsLysosomesThe Histiocytic Disorders: A Pathophysiologic AnalysisJEROME E. GROOPMAN, M.D., DAVID W. GOLDE, M.D.Biochemical, genetic and ultrastructural study of a family with the sea‐blue histiocyte syndrome/chronic non‐neuronopathic Niemann‐ Pick diseasePATHOLOGICAL, HISTOCHEMICAL AND ULTRASTRUCTURAL STUDIES ON SEA-BLUE HISTIOCYTES AND GAUCHER-LIKE CELLS IN ACQUIRED LIPIDOSIS OCCURRING IN LEUKEMIATWO DISTINCTIVE TYPES OF LIPID HISTIOCYTES APPEARING IN THE SPLEEN OF IDIOPATHIC THROMBOCYTOPENIC PURPURA - SEA-BLUE HISTIOCYTE AND FOAM CELL -Adult Niemann-Pick diseaseMonohistiocytic Series 1 December 1973Volume 79, Issue 6Page: 901-902KeywordsAutoimmune diseasesBone marrowGenetic diseasesHistiocytesHodgkin lymphomaIdiopathic thrombocytopenic purpuraPlateletsPolycythemia veraRabbitsRheumatoid arthritis Issue Published: 1 December 1973 PDF downloadLoading ...