tbuckley/cabot-search huggingface dataset:
Abstract 6251: Heat Shock Protein 27 is Localized in Intercalated Discs and is Extensively Modified by Methylglyoxal in Human Hearts
Authors: Thomas Gawlowski, Bernd Stratmann, Ines Stork, Reiner Körfer, Diethelm Tschoepe, Hendrik Milting
Journal: Circulation (2008)

Hyperglycemia plays an important role in the pathogenesis of diabetic complications including accumulation of methylglyoxal (MG), a highly reactive α-dicarbonyl metabolite of glucose degradation pathways. MG reacts in a non-enzymatic reaction with arginine residues of proteins which results in the formation of argpyrimidine. In several cell lines Hsp27 was found to be the most argpyrimidine containing protein. Whether Hsp27, which is high expressed in cardiac tissue, is also modified in heart, remains unclear. The aim of this investigation was to study the extent of Hsp27-modifications in heart failure and diabetes mellitus. Transmural myocardial samples from the left ventricle of explanted terminal failing hearts (diabetic: n=8; non-diabetic: n=8) and non-failing myocardium (NF) (n=6) without apparent signs of cardiac failure were collected. Cardiac tissue samples and rat cardiomyoblast cells H9c2, which were grown under normal and hyperglycaemic conditions, were investigated for the Hsp27-expression and modification by real-time PCR, western blotting and immunohistology. Hsp27 was significantly decreased (p&lt;0.05) in CM/DM (cardiomyopathy and diabetes mellitus) compared to NF. Relating to Hsp27-expression the MG-modification in diabetic hearts was significantly increased 3-fold (p&lt;0.05) compared to CM (cardiomyopathy) and 9-fold (p&lt;0.05) compared to NF. Consistent with the results in human heart samples, high glucose levels induced a down-regulation of Hsp27 in H9c2-cells in a dose-dependent manner. We also found an increased MG-modification of Hsp27 with higher concentrations of glucose. Noteworthy, we detected Hsp27 in the myocardial intercalated disc and in the M-line of the sarcomer in human cardiac tissue by immunohistology. In summary, we observed an increased argpyrimidine-modification of Hsp27 in the myocardium of patients with terminal heart failure and diabetes in comparison to non-failing donor hearts and explanted hearts from patients with cardiomyopathy. The argpyrimidine-modification of Hsp27 probably results from the diabetic myocardial metabolism and might be of impact for the progress of a cardiomyopathy in patients with diabetes mellitus.
Prospective study of patients' refusal of antipsychotic medication under a physician discretion review procedure
Authors: J A Kasper, S K Hoge, T Feucht-Haviar, J Cortina, B Cohen
Journal: American Journal of Psychiatry (1997)

The authors examined the refusal of antipsychotic medications and associated outcomes prospectively in a group of 348 psychiatric patients admitted to three acute inpatient units in a state-operated mental health facility in Virginia where psychiatrists have the discretionary power to administer treatment over patients' objections.Newly admitted patients were administered both a questionnaire to ascertain their attitudes toward admission and the Brief Psychiatric Rating Scale (BPRS). Patients who refused antipsychotic medication were identified, and data were collected on the length of refusal and whether the refusal episode was terminated voluntarily or involuntarily. A group of patients compliant with antipsychotic medication was selected for comparison on outcome measures, including the rate of seclusion and restraint and length of hospitalization.Patients who refused treatment were found to have significantly higher BPRS scores than were patients who complied with antipsychotic treatment and more negative attitudes toward hospitalization and past, present, and future treatment. Refusal episodes were brief, on average 2.8 days, and all patients, who refused treatment were treated. When compared with the compliant patients, patients who refused treatment were more likely to be assaultive, were more likely to require seclusion and restraint, and had longer hospitalizations.Psychiatrists exercised their discretion to promptly treat all patients who refused treatment. Nonetheless, these patients suffered more morbidity than compliant patients. This study suggests that the negative sequelae of in-hospital treatment refusal cannot be eliminated by rapid treatment. The policy implications are discussed.
Sustained Safety and Effectiveness of Paclitaxel-Eluting Stents for Femoropopliteal Lesions
Authors: Michael D. Dake, Gary M. Ansel, Michael R. Jaff, Takao Ohki, Richard R. Saxon, H. Bob Smouse, Scott A. Snyder, Erin E. O'Leary, Gunnar Tepe, Dierk Scheinert, Thomas Zeller
Journal: Journal of the American College of Cardiology (2013)

A prospective, multinational randomized controlled trial (RCT) and a complementary single-arm study evaluated the 2-year safety and effectiveness of a paclitaxel-coated drug-eluting stent (DES) in patients with superficial femoral artery lesions. The RCT compared the DES with percutaneous transluminal angioplasty (PTA) and provisional bare-metal stent (BMS) placement. Local drug delivery for superficial femoral artery lesions has been investigated with the intent of limiting restenosis similarly to DES for the coronary arteries. One-year outcomes of DES in the superficial femoral artery are promising, but longer-term benefits have not been established. In the RCT, patients were randomly assigned to primary DES implantation (n = 236) or PTA (n = 238). Acute PTA failure occurred in 120 patients, who underwent secondary randomization to DES (n = 61) or BMS (n = 59) placement. The single-arm study enrolled 787 patients with DES treatment. Compared with the control group, the primary DES group demonstrated significantly superior 2-year event-free survival (86.6% vs. 77.9%, p = 0.02) and primary patency (74.8% vs. 26.5%, p &lt; 0.01). In addition, the provisional DES group exhibited superior 2-year primary patency compared with the provisional BMS group (83.4% vs. 64.1%, p &lt; 0.01) and achieved higher sustained clinical benefit (83.9% vs. 68.4%, p = 0.05). Two-year freedom from target lesion revascularization with primary DES placement was 80.5% in the single-arm study and 86.6% in the RCT. Two-year outcomes with the paclitaxel-eluting stent support its sustained safety and effectiveness in patients with femoropopliteal artery disease, including the long-term superiority of the DES to PTA and to provisional BMS placement. (Evaluation of the Zilver PTX Drug-Eluting Stent in the Above-the-Knee Femoropopliteal Artery; NCT00120406; Zilver® PTX™ Global Registry; NCT01094678)
Abstract 5467: Magnetic Resonance Imaging Of Renal Ischemia Reperfusion Injury Using Microparticles Of Iron Oxide Targeting VCAM-1
Authors: Asim M Akhtar, Ye Chen, Jurgen E Schneider, Janet E Digby, Martina A McAteer, Kathryn Wood, Robin P Choudhury
Journal: Circulation (2008)
Abstract 17751: Depressive Symptoms are Associated with Arterial Stiffness in Men
Authors: Alanna A Morris, Riyaz S Patel, Joseph Poole, Yusuf Ahmed, Neli Stoyanova, Gary Gibbons, Arshed A Quyyumi, Viola Vaccarino
Journal: Circulation (2012)

Background: Depression has been linked to cardiovascular disease (CVD) risk, and multiple mechanisms are likely implicated. Although depression was previously associated with endothelial dysfunction, limited data are available on whether it also influences arterial stiffening.

Methods: We administered the Beck Depression Inventory II (BDI-II) to 595 community participants without a previous history of CVD (mean age 51±9 years, 62% female) enrolled in the Morehouse-Emory Partnership to Eliminate Cardiovascular Health Disparities (META-Health) study. BDI-II scores of ≥14 indicated presence of depressive symptoms. Central augmentation index (CAIx), a composite measure of arterial wave reflections and stiffness, and pulse wave velocity (PWV) were estimated using applanation tonometry (SphygmoCor, AtCor Medical).

Results: Participants with depressive symptoms had higher CAIx (adjusted for heart rate) compared to those without depressive symptoms (49.1±11.1 vs. 46.8±11.2%, p=0.02). There was no difference in PWV between the groups. After adjusting for age, race, smoking, hypertension, diabetes, body mass index, mean arterial pressure, glucose, and lipid profile, the total BDI-II score remained a significant predictor of higher CAIx in men (β=0.172, p=0.002), but not women (β=0.006, p=0.9). The p-value for gender X BDI-II score interaction was not significant (p=0.1).

Conclusions: Depressive symptoms are associated with increased arterial wave reflections in men. Further research is needed to define this association, and what the role of gender-based differences might be.
Determinants of anemia in cancer patients receiving chemotherapy
Authors: C. Robertson, P. Boyle, D. J. Kerr
Journal: Journal of Clinical Oncology (2004)

9719 Background: Anemia is common in cancer patients. It affects their quality of life and puts them at risk of severe complications when treated with blood transfusions. Little is known about the determinants of anemia. Improvements in this regard could lead to better management. Methods: Data were available from cross-sectional study surveys conducted in five European countries (France, Italy, Germany, Spain and United Kingdom) in 1999, 2000, 2001 and 2003 using the same Case Report Forms (CRF). Details of one cycle out of all chemotherapy cycles were recorded retrospectively in 41,114 patients. Anemia was defined as a hemoglobin level < 12g/dL. Risk of anemia was investigated through the effects of gender, age, chemotherapy type, country, cycle number and year of treatment with logistic regression (with 95% confidence intervals (CI)). Eight different tumor types were considered: breast, Small Cell lung (SCL), Non Small Cell lung (NSCL), ovarian, Acute Myeloid Lymphoma (AML), Non Hodgkin Lymphoma (NHL), Hodgkin Disease (HD), Multiple Myeloma (MM). Results: Across all tumor types anemia was reported in 67% of the patients and in > 95% in AML patients. Incidence increased over time for breast cancer, SCL, NSCL, NHL and MM. It was decreasing for ovarian cancer. Age had no independent effect except for NHL with less anemia in patients > 40 years. Consistent differences across countries were observed. The UK (Odds Ratio (OR) = 0.44), Spain (0.47) and Italy (0.54) have less likely anemia compared to Germany (OR = 1 (referent)) and France (0.85). Apart from MM and NHL a clear risk tendency for anemia to increase with subsequent cycles is observed. No association between cisplatin and platinum-based regimens with anemia in first cycle was seen. Conclusions: Anemia affects the majority of cancer patients receiving chemotherapy, being more frequent in men and during subsequent chemotherapy cycles. Research is required to better understand the frequency differences noted across countries in Europe and to identify patients at high risk, particularly in the initial cycle, since prevention and/or treatment measures are readily available. Author Disclosure Employment or Leadership Consultant or Advisory Stock Ownership Honoraria Research Funding Expert Testimony Other Remuneration Amgen
Abstract 2553: Effect of Pre-Transplant Extracorporeal Membrane Oxygenation on Pediatric Heart Transplantation Outcomes: An Analysis of the United Network for Organ Sharing Database
Authors: Nishant D Patel, Eric S Weiss, Lois U Nwakanma, Janet Scheel, Duke E Cameron, Luca A Vricella
Journal: Circulation (2007)

Introduction : Extracorporeal membrane oxygenation (ECMO) has been used as salvage therapy in children with intractable heart failure as a bridge to transplantation, but outcomes have not been examined in a large pediatric transplant database. Methods : All pediatric (&lt;18 years of age) primary heart transplant recipients reported to the United Network for Organ Sharing database from 1999 –2007 were reviewed and segregated according to need for pre-transplant ECMO. Survival was estimated by Kaplan-Meier method before and after propensity match analysis. Propensity-adjusted Cox regression modeling was used to identify predictors of mortality. Results : During the study period, 2141 children underwent first time heart transplantation: 154 (7%) were on ECMO. On univariate analysis, children bridged to heart transplant with ECMO had lower weight at operation (15 vs 27 kg; p &lt;0.0001), shorter time on the organ waitlist (31 vs 92 days; p =0.0002), longer post-transplant length of stay (40 vs 24 days; p &lt;0.0001), and higher incidence of stroke (5% vs 2%, p =0.02), reoperation (16% vs 8%; p =0.002), and infection (50% vs 25%; p &lt;0.0001). Kaplan-Meier 5-year survival was inferior for the pre-transplant ECMO group (55% vs 73%) (Figure ), both before and after propensity matching ( p &lt;0.0001). After propensity score adjustment, pre-transplant ECMO was a significant predictor of mortality (HR 2.7; 95% CI 1.8 – 4.1; p &lt;0.001). Conclusion : Patients on ECMO before heart transplant have inferior outcomes, even after adjustment for propensity scores, but still have acceptable 5-year survival. Improvement in survival will likely require refinement in mechanical support technology and practice. Kaplan -Meler Estimates of Morality 1999–2007 Stratified by ECMO
Long-Term Complications of Infection of the Female Genital Tract by Intracellular Sexually-Transmitted Microorganisms: A Review
Authors: M J Hare
Journal: Journal of the Royal Society of Medicine (1983)

present in 18% of cases as against 3% of the controls. In 33% of the infertile group mechanical blockage could be demonstrated in the fallopian tubes. The sequelae of nongonococcal infection appeared to be worse than those of gonococcal infection; taking into consideration women who had had one attack only, the infertility rates were 17% (nongonococcal) and 12% (gonococcal), and the tubal occlusion rates were 13% (non
Combination with gemcitabine renders dose dependent anti-cancer activity on alimta in rats with colorectal liver metastasis.
Authors: Michael Rodenbach, Ergyl Eyol, Martin R. Berger
Journal: Cancer Research (2004)

2015   Systemic chemotherapy has proven largely ineffective in treating liver metastasis of colorectal cancer. Chemoembolisation with drug combinations could be an effective strategy to reduce the tumor load of diffusely metastatic livers. To test this hypothesis, a transplantable orthotopic and isogenic rat model was used which is based on intraportal injection of 4*10 6  beta-galactosidase transfected CC531 rat colorectal cancer cells into male WAG/Rij rats (Wittmer et al, Clin Exp Met 17: 369, 1999). For treatment, alimta (Al; 30, 60, and 90 mg/kg) was injected intravenously to groups of 10 rats each on days 1-5 after transplantation, or intraportally in combination with degradable starch microspheres (DSM; 30 mg/kg) on day 1 only. For sequential combination therapy, groups of 10 rats each pretreated with alimta received an injection of DSM plus gemcitabine (Gem; 50mg/kg) into the hepatic artery on day seven after tumor cell inoculation (day 1). At 21 days after tumor inoculation the experiment was terminated, the livers were weighed and the load of CC531-lacZ cells growing in the liver was checked by luminometric determination of beta-galactosidase activity. No toxicity in terms of mortality or weight loss greater than 10% of initial body weight was observed. Liver weights corresponded closely to tumor cell numbers. The mean tumor cell load of control animals (n=21) was 4*10 9  cells per liver. Monotherapy with Al was ineffective as shown by T/C% values of 83, 73, and 81 following intravenous administration daily for 5 days with 30, 60, and 90mg/kg, respectively. Single intraportal chemo-embolisation with DSM and the same Al doses was also ineffective (95, 108, and 113 T/C%). Combination of the low dose of Al with chemo-embolisation by DSM plus Gem into the hepatic artery, however, induced a significant anticancer effect following both, intravenous (28 T/C%) and intraportal (30 T/C%) administration of Al (p
The Primary Open-Angle African American Glaucoma Genetics Study
Authors: Emily S. Charlson, Prithvi S. Sankar, Eydie Miller-Ellis, Meredith Regina, Raymond Fertig, Julia Salinas, Maxwell Pistilli, Rebecca J. Salowe, Allison L. Rhodes, William T. Merritt, Michael Chua, Benjamin T. Trachtman, Harini V. Gudiseva, David W. Collins, Venkata Ramana Murthy Chavali, Charles Nichols, Jeffrey Henderer, Gui-shuang Ying, Rohit Varma, Eric Jorgenson, Joan M. O'Brien
Journal: Ophthalmology (2015)
Accident and emergency departments need management guidelines
Authors: J. Wright, C. Stark
Journal: BMJ (1995)

approach.Case finding, notification of cases, enhanced surveillance, and modification of the environment in which the disease exists are strategies that can usefully be applied to bullying.Doctors are perhaps better placed than parents to push this approach.We need also to recruit the vast majority of children who are neither bullies nor victims.In my survey of a secondary school in Nottingham the response of three quarters of children to the bully- ing of another child was that of a bystander who does not want to get involved; a fifth said they could be persuaded to join in (unpublished data).Whitney and Smith found that most children did nothing to help victims either because they did not know how to help or because they thought it was not their business.2Perhaps this statistic would make a good indicator of the success of an anti- bullying programme.Children should be taught not only not to bully others but also not to tolerate bullying of others.Health care staff working with children in the primary care setting have a vested interest in working in concert with school authorities towards this ideal: they will have less morbidity related to bullying to deal with.One approach would be to regard the detection of a case of bullying as an indication of serious problems in the interrelation- ships of children in the school.As in established child protection procedures, a case conference should be called of all professionals concerned and a strategy agreed for the prevention of future cases.
Vascular Endothelial Growth Inhibitor (VEGI; TNFSF15) induction of apoptosis in endothelial cells is NF-κB dependent
Authors: Sammy R. Grimaldo, Luyuan Li
Journal: Cancer Research (2006)

Proc Amer Assoc Cancer Res, Volume 47, 2006

244 

The purpose of this study was to investigate the role of NF-κB signaling pathway has in VEGI-induced cell death. We determined the activation of NF-κB with a nuclear translocation assay using an ELISA of nuclear extracts. We then tested the ability of an IKK kinase inhibitor, parthenolide (PN), to abrogate VEGI-induced NF-κB activation. Growth rates of adult bovine aortic endothelial (ABAE) cells were determined either by an MTS assay Or by cell counting. We then investigated if VEGI is still able to activate caspases-3, -8, -9, and -10 in the presence of parthenolide, using a substrate assay, and determined the ability of two pharmacological inhibitors Bay 11-7082 and Bay 11-7085 ability to prevent caspase 3 activation by VEGI. The effect of parthenolide was compared to inhibitory effects to TNFα. We have determined that in the presence of parthenolide that ABAE cells are no longer susceptible to the inhibitory effects of VEGI. VEGI was able to increase a 7-fold induction of NF-κB in the nucleus. Parthenolide was determined to be effective in inhibiting activation of NF-κB. We found that parthenolide protected ABAE cells from the inhibitory effects of VEGI as shown by a proliferation assay and cell count after 48 and 72 hours. We also found that parthenolide sequestered VEGI activation of caspase-3, -8, -9, and -10, suggesting, that NF-κB is necessary for the activation of the caspase pathway. We further confirmed NF-κB role in VEGI-activation of caspase-3 using Bay 11-7082 and Bay 11-7085. Interestingly, we found that PN did not exert a similar protective effect on ABAE cell proliferation when treated with TNFα. These findings suggests that NF-κB is necessary for the activation of the caspase pathway that is activated by VEGI and not TNFα.
Regional Left Ventricular Electric and Mechanical Activation and Relaxation⁎⁎Editorials published in the Journal of the American College of Cardiologyreflect the views of the authors and do not necessarily represent the views of JACCor the American College of Cardiology.
Authors: Otto A. Smiseth, Espen W. Remme
Journal: Journal of the American College of Cardiology (2005)
Delayed Effects in Mice Following Acute Total-Body X Irradiation: Modification by Experimental Treatment&lt;xref ref-type="fn" rid="FN1"&gt;2&lt;/xref&gt;
Authors: J HOLLCROFT, E LORENZ, E MILLER, C C CONGDON, R SCHWEISTHAL, D UPHOFF
Journal: JNCI Journal of the National Cancer Institute (1957)

Journal Article Delayed Effects in Mice Following Acute Total-Body X Irradiation: Modification by Experimental Treatment Get access Joanne Hollcroft, Joanne Hollcroft Radiation Branch, National Cancer Institute7, Bethesda, Maryland; Biology Division, Oak Ridge National Laboratory, Oak Ridge, Tennessee; and Division of Biological and Medical Research, Argonne National Laboratory, Lemont, Illinois Search for other works by this author on: Oxford Academic PubMed Google Scholar Egon Lorenz, Egon Lorenz Radiation Branch, National Cancer Institute7, Bethesda, Maryland; Biology Division, Oak Ridge National Laboratory, Oak Ridge, Tennessee; and Division of Biological and Medical Research, Argonne National Laboratory, Lemont, Illinois Search for other works by this author on: Oxford Academic PubMed Google Scholar Eliza Miller, Eliza Miller Radiation Branch, National Cancer Institute7, Bethesda, Maryland; Biology Division, Oak Ridge National Laboratory, Oak Ridge, Tennessee; and Division of Biological and Medical Research, Argonne National Laboratory, Lemont, Illinois Search for other works by this author on: Oxford Academic PubMed Google Scholar Charles C. Congdon, Charles C. Congdon Radiation Branch, National Cancer Institute7, Bethesda, Maryland; Biology Division, Oak Ridge National Laboratory, Oak Ridge, Tennessee; and Division of Biological and Medical Research, Argonne National Laboratory, Lemont, Illinois Search for other works by this author on: Oxford Academic PubMed Google Scholar Robert Schweisthal, Robert Schweisthal Radiation Branch, National Cancer Institute7, Bethesda, Maryland; Biology Division, Oak Ridge National Laboratory, Oak Ridge, Tennessee; and Division of Biological and Medical Research, Argonne National Laboratory, Lemont, Illinois Search for other works by this author on: Oxford Academic PubMed Google Scholar Delta Uphoff Delta Uphoff Radiation Branch, National Cancer Institute7, Bethesda, Maryland; Biology Division, Oak Ridge National Laboratory, Oak Ridge, Tennessee; and Division of Biological and Medical Research, Argonne National Laboratory, Lemont, Illinois Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 18, Issue 5, May 1957, Pages 615–640, https://doi.org/10.1093/jnci/18.5.615 Published: 01 May 1957 Article history Received: 29 November 1956 Published: 01 May 1957
Exposure to welding fumes and lower airway infection with Streptococcus pneumoniae
Authors: Reetika Suri, Jimstan Periselneris, Sophie Lanone, Patti C. Zeidler-Erdely, Geoffrey Melton, Keith T. Palmer, Pascal Andujar, James M. Antonini, Vanessa Cohignac, Aaron Erdely, Ricardo J. Jose, Ian Mudway, Jeremy Brown, Jonathan Grigg
Journal: Journal of Allergy and Clinical Immunology (2015)
Frequent Mutations in the Calreticulin Gene CALR in Myeloproliferative Neoplasms
Authors: Klampfl Thorsten, Heinz Gisslinger, Ashot S Harutyunyan, Harini Nivarthi, Elisa Rumi, Jelena D. Milosevic, Nicole C.C. Them, Tiina Berg, Bettina Gisslinger, Daniela Pietra, Doris Chen, Gregory I. Vladimer, Klaudia Bagienski, Chiara Milanesi, Ilaria Carola Casetti, Emanuela Sant'Antonio, Virginia Ferretti, Chiara Elena, Fiorella Schischlik, Ciara Cleary, Melanie Six, Martin Schalling, Andreas Schönegger, Christoph Bock, Luca Malcovati, Christiana Pascutto, Giulio Superti-Furga, Mario Cazzola, Robert Kralovics
Journal: Blood (2013)