tbuckley/cabot-search huggingface dataset:
940-73 Predictive Value for Major Arrhythmic Events of Ventricular Arrhythmias Detected in the Subacute Phase of a Fibrinolysed Myocardial Infarction. An Analysis of the GISSI-2 Data Base
Authors: Paolo Giani, Fausto Avanzini, Giuseppe Bagliani, Antonio Galati, Paolo Pucci, Eugenio Santoro
Journal: Journal of the American College of Cardiology (1995)
Hepatocellular ballooning in NASH
Authors: Stephen Caldwell, Yoshihiro Ikura, Daniela Dias, Kosuke Isomoto, Akito Yabu, Christopher Moskaluk, Patcharin Pramoonjago, Winsor Simmons, Harriet Scruggs, Nicholas Rosenbaum, Timothy Wilkinson, Patsy Toms, Curtis K. Argo, Abdullah M.S. Al-Osaimi, Jan A. Redick
Journal: Journal of Hepatology (2010)
Late onset type 1 diabetes
Authors: D. Lasserson, R. Fox, A. Farmer
Journal: BMJ (2012)

A 41 year old man from an Indian family whose father had type 2 diabetes presented to his general practitioner with a four week history of increasing thirst and polyuria. He had not noticed any weight loss. Blood tests were arranged to confirm the diagnosis of diabetes. One week later, after having to push his car home, he began to feel exhausted and developed intermittent vomiting, which he attributed to exertion. Over the next two days he became more unwell, and the out of hours primary care service was contacted. He was reviewed urgently and admitted with diabetic ketoacidosis.

A spectrum of autoimmune diabetes presents in adulthood, with type 1 diabetes characterised by the requirement of insulin at diagnosis to control glycaemia and prevent ketogenesis. Latent autoimmune diabetes of adulthood (LADA) also occurs but with much slower progression to requiring insulin after initial diagnosis.

#### How common is late onset type 1 diabetes?

Similar rates of ketoacidosis are seen in patients with type 1 diabetes at diagnosis in adulthood and childhood,3 and diagnostic delay is thought to account for many presentations with ketoacidosis in children.4 Although the classic symptoms produced by hyperglycaemia are unlikely to be missed, there may be a delay in accurately identifying patients requiring insulin at diagnosis if there is a clinical resemblance to type …
Production of platelet-activating factor by human vascular endothelial cells: evidence for a requirement for specific agonists and modulation by prostacyclin.
Authors: G A Zimmerman, T M McIntyre, S M Prescott
Journal: Circulation (1985)

Primary cultures of confluent endothelial cells derived from human umbilical veins produce platelet-activating factor (PAF) (1-alkyl-2-acetyl-sn-glycero-3-phosphocholine) when stimulated with appropriate agonists. Highly purified human thrombin and calcium ionophore A23187 stimulate the incorporation of [3H] acetate into a lipid product that has been identified as PAF by its behavior in thin-layer chromatographic and high-performance liquid chromatographic systems, the presence of characteristic biologic activity, and appropriate response to phospholipases. A number of other humoral mediators, examined because they directly influence the activity of vascular cells or because they may mediate endothelial injury, do not stimulate PAF production by endothelial cells. This indicates that the synthesis of PAF by cultured human endothelial cells is a response to specific agonists and is not an unregulated event that occurs as a result of nonspecific cellular perturbation. The PAF produced by thrombin-treated endothelial cells is a potent stimulus for platelet activation, as assayed by the aggregation of human platelets in autologous plasma. The production of PAF by endothelial monolayers is attenuated by prostacyclin, another product of stimulated endothelial cells. Conversely, PAF production is enhanced by treatment of the endothelial cells with indomethacin, an inhibitor of prostacyclin synthesis from arachidonic acid, indicating that endogenously generated prostacyclin may modulate PAF synthesis. The potential to synthesize PAF, a unique lipid autocoid that stimulates the activation of both platelets and polymorphonuclear leukocytes, suggests that endothelial cells can directly influence the activity of these circulating effector cells. This biologic potential may be important in the interaction of the endothelium with circulating blood cells in physiologic conditions and in syndromes of vascular injury.
Identification of TTR-Related Subclinical Amyloidosis With 99mTc-DPD Scintigraphy
Authors: Simone Longhi, Pier Luigi Guidalotti, Candida Cristina Quarta, Christian Gagliardi, Agnese Milandri, Massimiliano Lorenzini, Luciano Potena, Ornella Leone, I Bartolomei, Francesca Pastorelli, Fabrizio Salvi, Claudio Rapezzi
Journal: JACC. Cardiovascular imaging (2014)
Efficacy of Nifedipine in Rest Angina Refractory to Propranolol and Nitrates in Patients with Obstructive Coronary Artery Disease
Authors: JEFFREY W. MOSES
Journal: Annals of Internal Medicine (1981)

Nineteen patients with recurrent rest angina were given oral nifedipine. All patients had chest discomfort refractory to propranolol and oral or topical nitrates given to tolerance. The addition of nifedipine, 30 to 120 mg daily, abolished rest angina in 14 patients, decreased its frequency in two, and had no effect in three patients. Five of seven patients on long-term nifedipine (mean, 6.2 ±3.4 months) remained free of rest pain. Of seven patients who had their nifedipine dose decreased or discontinued, five had recurrent rest angina. Of the 19 patients, 16 had coronary angiography. Five had three-vessel obstructive disease (greater than 75% lesion), six had two-vessel obstructive disease, and five had one-vessel obstructive disease. The remaining three unstudied patients had pathologic Q waves in the ECG. Thus nifedipine appears to be an efficacious agent in the treatment of refractory rest angina in patients with obstructive coronary artery disease.
Ethics and in-vitro fertilisation.
Authors: P K Smith
Journal: BMJ (1982)

A recent conference arranged by the Centre for Human Bioethics at Australia's Monash University considered the ethical issues raised by in vitro fertilization and related technologies. While many participants supported the traditional Roman Catholic view that man should not intrude into the origin of human life, the author of this brief article sees the important questions as involving medicolegal difficulties and the allocation of scarce medical resources.
Thyrotoxicosis Factitia Veterinarius
Authors: Sheila Feit
Journal: Annals of Internal Medicine (1997)

Letters15 July 1997Thyrotoxicosis Factitia VeterinariusSheila Feit, MD and Helen Feit, MDSheila Feit, MDSyosset, NY 11791Villanova, PASearch for more papers by this author and Helen Feit, MDSyosset, NY 11791Villanova, PASearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-127-2-199707150-00031 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:We describe a case of “thyrotoxicosis factitia canis.”A 50-year-old woman presented with new-onset nervousness and dizziness. Her medical history was notable for hypertension treated with enalapril, 10 mg four times daily. Further questioning revealed that the patient's dog, which “had no thyroid,” was being treated with L-thyroxine, 0.6 mg four times daily (a typical canine dosage). It seems that, at some point, the patient may have inadvertently switched her medication with her dog's medication. The results of physical examination were normal except for tremor. The pulse was 72 beats/min and regular. The patient was followed after ... Author, Article, and Disclosure InformationAffiliations: Syosset, NY 11791Villanova, PA PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoThyrotoxicosis: A Lesson From the Slaughterhouse Thomas Pusl , Hendrik Jaehnig , and Robert Dorn Metrics Cited ByMedical and Nonstroke Neurologic Causes of Acute, Continuous Vestibular SymptomsExogenous ThyrotoxicosisExogenous thyrotoxicosis in dogs attributable to consumption of all-meat commercial dog food or treats containing excessive thyroid hormone: 14 cases (2008–2013)Thyrotoxicosis: A Lesson From the SlaughterhouseThomas Pusl, MD, Hendrik Jaehnig, MD, and Robert Dorn, MDAn Unusual Case of Central Hypothyroidism and Thyrotoxicosis Factitia 15 July 1997Volume 127, Issue 2Page: 168KeywordsAnxietyHeart rateHypertensionThyroglobulinThyroidThyroxine Issue Published: 15 July 1997 CopyrightCopyright © 1997 by American College of Physicians. All Rights Reserved.PDF DownloadLoading ...
Corneal Sensitivity Is Reduced and Relates to the Severity of Neuropathy in Patients with Diabetes
Authors: Sandip Kumar Dash
Journal: Diabetes Care (2007)

I read with interest the study by Tavakoli et al. (1) and found it to be interesting and useful in the management of diabetes for preventing further complications; however, I would like to make a few comments. In this study (1), whether patients with …
Health Care Reform and Graduate Medical Education
Authors: John K. Iglehart
Journal: New England Journal of Medicine (1994)

For almost three decades, the federal government has provided billions of dollars annually to support graduate medical education without regard to the number and balance of generalists and specialists produced by the nation's teaching hospitals. Now, believing that the increasing ratio of specialists to generalists has deleterious effects on the cost1,2 and quality of health care and concerned about a surfeit of physicians, President Bill Clinton has recommended that residency positions be allocated and funded through a centralized regulatory process sponsored by the federal government. Although Clinton's call for nationally coordinated planning of the physician work force is an . . .
Iodine and the thyroid.
Authors: B Thjodleifsson
Journal: BMJ (1978)

This was shown in the survey referred to earlier as well as in Dr Tomlin's study.With the routine use of ventilators the use of low-flow rebreathing systems with carbon dioxide absorption appears to be diminishing.The higher gas flows employed are adding to the pollution.In addition flowmeters and vaporisers often remain open in anaesthetic rooms long after the patient has gone back to the ward via the operating theatre.The problem of pollution is perhaps well recognised now.The current shortage of anaesthetists is putting more stress on the available people and perhaps forcing them to face the pollution for longer periods.It must be even more so in Birmingham!
An inherited mutation leading to production of only the short isoform of GATA-1 is associated with impaired erythropoiesis
Authors: Luciana M Hollanda, Carmen S P Lima, Anderson F Cunha, Dulcinéia M Albuquerque, José Vassallo, Margareth C Ozelo, Paulo P Joazeiro, Sara T O Saad, Fernando F Costa
Journal: Nature Genetics (2006)
A Double-Blind Study of Oral Acyclovir for Suppression of Recurrences of Genital Herpes Simplex Virus Infection
Authors: John M. Douglas, Cathy Critchlow, Jacqueline Benedetti, Gregory J. Mertz, James D. Connor, Marie A. Hintz, Anita Fahnlander, Michael Remington, Carol Winter, Lawrence Corey
Journal: New England Journal of Medicine (1984)

Patients with frequently recurring genital herpes were enrolled in a double-blind placebo-controlled trial comparing 200-mg acyclovir capsules, given five or two times daily, with placebo. Of 47 placebo recipients, 44 (94 per cent) had recurrences during the 120-day treatment period, compared with 13 (29 per cent) of 45 patients treated with acyclovir five times daily and 18 of 51 (35 per cent) treated with acyclovir twice daily (P less than 0.001 for each regimen compared with placebo). The median time to the first clinical recurrence was 18 days in placebo recipients, compared with over 120 days in both acyclovir-treated groups (P less than 0.001 for both groups compared with placebo). The mean monthly recurrence rate during the medication period was 0.86 in placebo recipients, compared with 0.13 in patients treated with acyclovir five times daily and 0.14 in patients treated with acyclovir twice daily (P less than 0.001 for both groups compared with placebo). While receiving therapy, 86 of 96 acyclovir-treated patients had over a 50 per cent reduction in their pretreatment recurrence rate. Breakthrough recurrences in acyclovir recipients were of shorter duration and associated with a lower frequency of viral shedding than recurrences in placebo recipients. After medication was discontinued, the subsequent recurrence rate returned to pretreatment frequencies. Daily oral acyclovir was well tolerated. We conclude that oral acyclovir given for four months markedly reduces but does not completely prevent recurrences of genital herpes and does not influence the long-term natural history of the disease.
An approach to the understanding of the nasal early‐phase reaction induced by nasal allergen challenge
Authors: D. Wang, J. Smitz, S. Waterschoot, P. Clement
Journal: Allergy (1997)

Quantitative determinations of the inflammatory mediators in nasal secretions were performed and correlated with the objective nasal symptoms within 1 h after nasal allergen challenge (NAC). Twenty‐six patients with seasonal allergic rhinitis were enrolled outside the pollen season. All measurements were performed before (as a baseline control) and at 1, 5, 10, 30, and 60 min after NAC. This study aimed to clarify the pathogenic mechanism of the early‐phase reaction (EPR) by monitoring the evolution of early‐phase mediators in nasal secretions and the presence of nasal symptoms during this period. The results showed that, after NAC, the maximal mediator concentration was already reached after 1 min for histamine (124 ng/g), 5 min for tryptase (56 μU/g), and 5‐10 min for leukotriene C 4 (40 ng/g). Itching and sneezing started as early as 20‐30 s, and they were predominant symptoms within 5 min. Rhinorrhea and nasal obstruction started a few minutes after NAC and lasted until more than 1 h after NAC. There was no significant correlation between any single mediator and nasal symptoms during the sampling period. In conclusion, this study demonstrated that during the EPR the presence of nasal symptoms involves a complex mechanism, reflecting the interaction between the mediators released by inflammatory cells, and the receptors on different target organs. When evaluating symptoms during the EPR, one must consider not only the severity of these symptoms but also the time period within which these symptoms occur. For the symptoms of nasal obstruction and rhinorrhea, the early‐phase reaction often lasted more than 1 h.
Pulmonary Edema Associated With Intravenous Vinblastine
Authors: Robert H. Israel
Journal: JAMA (1978)

To the Editor.—  A recent case demonstrated an association between the intravenous (IV) administration of vinblastine and the development of pulmonary edema.  Report of a Case.—  A 64-year-old woman is receiving chemotherapy for infiltrating duct carcinoma of the breast metastatic to bones. A breast mass was diagnosed in May 1972, with a subsequent right radical mastectomy. One of 24 axillary nodes was abnormal. Bony metastasis appeared in November 1974. She has been treated sequentially with estrogen, cryohypophysectomy, and combination chemotherapy (first with cyclophosphamide [Cytoxan], methotrexate, and fluorouracil; then doxorubicin hydrochloride [Adriamycin] and cyclophosphamide and recently with mitomycin and vinblastine sulfate). She has hypertension, which has been therapeutically controlled since 1969. The insidious onset of congestive heart failure developed in May 1977, consistent with doxorubicin toxicity (total dose, 400 mg/sq m). Doxorubicin therapy was discontinued, and she responded to digitalization and diuresis. She has remained well compensated with digoxin, hydrochlorothiazide (Hydrodiuril),
Vibrio vulnificus. Man and the sea
Authors: J. M. Johnston
Journal: JAMA (1985)

To identify risk factors for<i>Vibrio vulnificus</i>infections, we performed a regional case-control study of 19 patients identified by isolates received at a state reference laboratory. Interviews with patients or surviving relatives and with three controls for each patient were compared in a matched analysis. Patients with<i>V vulnificus</i>wound infection were more likely than controls to have sustained a puncture wound while handling fresh seafood or to have been exposed to salt water. More patients with primary septicemia than controls had eaten raw oysters before the onset of illness. Other risk factors for septicemia included underlying liver disease, hematopoietic disorders, chronic renal insufficiency, use of immunosuppressive agents, and heavy alcohol consumption. Although<i>V vulnificus</i>infection is unusual, with a regional incidence of 0.8 per 100,000 population in this study, septicemia in the immunosuppressed patient is a devastating illness that can be prevented by not eating raw seafood. (<i>JAMA</i>1985;253:2850-2853)
Metal speciation in environmental and biological systems.
Authors: Q Fernando
Journal: Environmental Health Perspectives (1995)

Metal ions form complexes with naturally occurring complexing agents or ligands released from industrial activity. The metal complexes are thereby mobilized and transported in environmental and biological systems. The impact of such metal complexes depends on the metal complex species that are kinetically and thermodynamically stable in these homogeneous and heterogeneous systems. The distribution of metal complex species in these complex systems can be calculated from available formation constant data. This article describes the importance of verifying the validity of these calculations by employing experimental techniques that can speciate metal complexes.
Cell-specific expression of alpha 1-antitrypsin in human intestinal epithelium.
Authors: E P Molmenti, D H Perlmutter, D C Rubin
Journal: Journal of Clinical Investigation (1993)

alpha 1-Antitrypsin (alpha 1-AT) is an acute phase plasma protein predominantly derived from the liver which inhibits neutrophil elastase. Previous studies have suggested that alpha 1-AT is also expressed in human enterocytes because alpha 1-AT mRNA could be detected in human jejunum by RNA blot analysis, and alpha 1-AT synthesis could be detected in a human intestinal adenocarcinoma cell line Caco2, which spontaneously differentiates into villous-like enterocytes in tissue culture. To definitively determine that the alpha 1-AT gene is expressed in human enterocytes in vivo, we examined tissue slices of human jejunum and ileum by in situ hybridization. The results demonstrate specific hybridization to enterocytes from the bases to the tips of the villi. Although there was no hybridization to enterocytes in most of the crypt epithelium, there was intense specific hybridization in one region of the crypt. Double-label immunohistochemical studies showed that alpha 1-AT and lysozyme co-localized to this region, indicating that it represented Paneth cells. Finally, there was a marked increase in hybridization to alpha 1-AT mRNA in villous enterocytes and Paneth cells in Crohn's disease. The results of this study provide definitive evidence that alpha 1-AT is expressed in human jejunal and ileal enterocytes in vivo, and show that alpha 1-AT is also a product of Paneth cells. Together with the results of other studies, these data raise the possibility that alpha 1-AT detected in fecal alpha 1-AT clearance assays for diagnosing protein-losing enteropathies is predominantly derived from sloughed enterocytes.
KIF5B-RET fusions in lung adenocarcinoma
Authors: Takashi Kohno, Hitoshi Ichikawa, Yasushi Totoki, Kazuki Yasuda, Masaki Hiramoto, Takao Nammo, Hiromi Sakamoto, Koji Tsuta, Koh Furuta, Yoko Shimada, Reika Iwakawa, Hideaki Ogiwara, Takahiro Oike, Masato Enari, Aaron J Schetter, Hirokazu Okayama, Aage Haugen, Vidar Skaug, Suenori Chiku, Itaru Yamanaka, Yasuhito Arai, Shun-ichi Watanabe, Ikuo Sekine, Seishi Ogawa, Curtis C Harris, Hitoshi Tsuda, Teruhiko Yoshida, Jun Yokota, Tatsuhiro Shibata
Journal: Nature Medicine (2012)
The tumor suppressor PP2A is functionally inactivated in blast crisis CML through the inhibitory activity of the BCR/ABL-regulated SET protein
Authors: Paolo Neviani, Ramasamy Santhanam, Rossana Trotta, Mario Notari, Bradley W. Blaser, Shujun Liu, Hsiaoyin Mao, Ji Suk Chang, Annamaria Galietta, Ashwin Uttam, Denis C. Roy, Mauro Valtieri, Rebecca Bruner-Klisovic, Michael A. Caligiuri, Clara D. Bloomfield, Guido Marcucci, Danilo Perrotti
Journal: Cancer Cell (2005)
VA and Women’s Health
Authors: Mike Mitka
Journal: JAMA (2009)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
An Unusual Cutaneous Reaction in Mental Defectives After Vole Bacillus Vaccination by Multiple Puncture and Its Treatment
Authors: J. A. H. Wylie, D. H. Bennett, J. Swithinbank
Journal: Thorax (1954)

Intrauterine infections have been associated with pregnancy complications that are also linked with increased trophoblast apoptosis. TLRs are key components of the innate immune system which recognize conserved sequences on the surface of pathogens and trigger effector cell functions. We hypothesize that intrauterine infections may cause the excessive trophoblast cell apoptosis observed in abnormal pregnancies and that TLR may provide a mechanism of pathogenesis. In this study we describe the expression and function of TLR-2 and TLR-4 in first trimester trophoblast cells. Although ligation of TLR4 induced cytokine production by trophoblast cells, TLR-2 activation induced apoptosis. TLR-2 mediated apoptosis was dependent upon the Fas-associated death domain, the inactivation of the X-linked inhibitor of apoptosis, and the activation of caspases 8, 9, and 3. These results suggest that certain intrauterine infections may directly induce trophoblast cell death through TLR-2. Our findings provide a novel mechanism of pathogenesis for certain pregnancy complications in which there is engagement of the innate immune system.
Feinstrukturen der Leberoberfläche bei laparoskopischer Lupendarstellung
Authors: H. Lent
Journal: Endoscopy (1969)

By intravital examination of the liver surface with a magnifying optical system one succeeds in getting additional morphological and pathophysiological information which may help to solve some diagnostic problems in correlation to the histological findings. A variety of surface abnormalities are shown especially the structure of the lymphatic vessels, veins and arteries in normal and diseased liver.
Haemophilus influenzae tenosynovitis.
Authors: J C Leek, D L Robbins
Journal: Annals of the Rheumatic Diseases (1980)

and the presence of gold in the cellular mass; and (3) the finding that ABO blood group and rhesus type has no influence on whether gold is bound to erythrocytes.Taken together these 2 studies, using different highly sensitive and precise techniques to measure gold, confirm that a large proportion of RA patients have gold in blood cells, and that erythrocyte gold binding is similar with aurothioglucose and gold sodium thiomalate.