tbuckley/cabot-search huggingface dataset:
Abstract 17775: Foxo3a Regulates Response to Coxsackievirus B3 Myocarditis via microRNA-155 Triggered NK-cell Activity
Authors: Luise Holzhauser, Madlen Loebel, Alexander Jenke, Sandra Bauer, Sonya Demski, Sabrina Wilk, Sandra Pinkert, Henry Fechner, Wolfgang Poller, Heinz-Peter Schultheiss, Carmen Scheibenbogen, Carsten Skurk
Journal: Circulation (2014)

Background: FoxO3a is a transcription factor crucial in regulation of cell metabolism, stress resistance and immunity. Recently polymorphisms of FOXO3a have been associated with favorable outcome in inflammatory disease. However, mechanistic insight in FoxO3a effects is still limited. Here, we investigated the role of FoxO3a on NK-cell responses in viral myocarditis. Methods: A mouse model of Coxsackie Virus B3 (CVB3) myocarditis in wild-type and FoxO3a-/- mice was used to investigate the effects of FoxO3a on viral load and inflammation. Characterization of NK cells was performed by cytotoxic assay, surface marker- and interferon expression. Results: FoxO3a-/- mice showed significantly reduced myocardial inflammation, lower viral titers and attenuated expression of pro-inflammatory cytokines compared to wild-type mice 7 days post infection. Viral titers were significantly lower in FoxO3a-/- mice at day 3 while IFN γ and NKp46 expression were up-regulated within the heart suggesting early viral control by enhanced NK cell activity. There were no differences in expression of CAR (coxsackie-adenovirus receptor). Additionally NKp46+ splenic NK cells of FoxO3a-/- mice exhibited a superior functional status ex vivo determined by enhanced expression of CD69, higher frequencies of CD11b+CD27+ effector NK cells and increased cytotoxicity compared to NK cells of wild-type littermates. These effects were not due to different levels of apoptosis. MicroRNA-155 expression, recently reported to be essential in NK-cell activation, was significantly elevated in FoxO3a-/- NK cells while its inhibition led to diminished production of IFNγ in Foxo3a deficient animals. Moreover analysis of healthy human donors for the gain of function FoxO3a SNP rs9400239 revealed significantly reduced CD107a dependent degranulation activity in donors homozygous for the allelic variant. Conclusion: Our results implicate FoxO3a directly in regulation of NK-cell function and suggest an important role in innate immune responses to viral infection. While the anti-inflammatory effects of FoxO3a seem beneficial in chronic inflammation the suppression of innate immunity in acute viral myocarditis could have detrimental effects.
Conditioning with rabbit versus horse ATG dramatically alters clinical outcomes in identical twins with severe aplastic anemia transplanted with the same allogeneic donor
Authors: P. T. Vo, J. Pantin, C. Ramos, L. Cook, E. Cho, R. Kurlander, H. Khuu, J. Barrett, S. Leitman, R. W. Childs
Journal: Journal of Hematology & Oncology (2015)

Severe aplastic anemia (SAA) is a rare disorder leading to bone marrow failure, which if left untreated, is invariably fatal. Conventional therapies with immunosuppressive therapy or allogeneic hematopoietic stem cell transplantation (HSCT) are highly effective. HSCT can offer a greater outcome in younger patients who have an available HLA match-related donor. Recent studies showing the addition of antithymocyte globulin (ATG) to the conditioning regimen improves engraftment and reduces the risk of graft-versus-host disease (GVHD).There are currently two ATG preparations in the USA, equine (or horse) and rabbit ATG. These agents are pharmacologically distinct, having significant differences in their pharmacokinetics and in vivo immunosuppressive effects [N Engl J Med 365(5):430-438, 2011]. Here, we report a case of two monozygotic twins with constitutional SAA that evolved to myelodysplastic syndrome (MDS) who both underwent allogeneic peripheral blood stem cell transplantation (PBSC) from the same single HLA antigen mismatched sibling donor with the only difference in the transplant regimen being the type of ATG used in the preparative regimen; one twin received horse ATG and the other received rabbit ATG during conditioning. This report emphasizes that dramatic differences in donor T cell chimerism and clinical outcomes including GVHD can occur as a consequence of the type of ATG that is utilized in the transplant conditioning regimen. These differences highlight that these agents should not be considered interchangeable drugs when used in this setting.
Using administrative data for epidemiological research: case study to identify persons with periodontitis
Authors: Leslie Spangler, Monica Chaudhari, William E. Barlow, Katherine M. Newton, Ronald Inge, Philippe Hujoel, Robert J. Genco, Robert J. Reid
Journal: Periodontology 2000 (2011)

Abstract The availability of automated administrative databases in medical and dental healthcare, combined with modern computing power, allows sophisticated multi‐layered analyses of the causes and consequences of care delivered to large populations. These automated databases are now also commonly linked to data extracted from electronic medical records, and are used to measure health system performance, adjust payments, assess providers for quality improvement purposes, and inform policy decisions. Use of health insurance databases can be particularly powerful when linked through common unique identifiers to allow examination of the influences of dental care on medical outcomes and costs, and vice versa. This review describes the growing use of these databases for epidemiological and health services research, their advantages and limitations, and presents a case study in which dental claims data are used to identify persons with periodontitis in order to enable critical assessment of the relationship between periodontal interventions and systemic health outcomes/medical costs.
ROYAL SOCIETY OF MEDICINE.
Authors: Brian Russell
Journal: British Journal of Dermatology (1969)

Journal Article ROYAL SOCIETY OF MEDICINE: SECTION OF DERMATOLOGY Get access Brian Russell Brian Russell President Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 81, Issue 5, 1 May 1969, Pages 386–388, https://doi.org/10.1111/j.1365-2133.1969.tb14005.x Published: 01 May 1969
Incidence of Type 2 Diabetes in the Randomized Multiple Risk Factor Intervention Trial
Authors: George Davey Smith, Yiscah Bracha, Kenneth H. Svendsen, James D. Neaton, Steven M. Haffner, Lewis H. Kuller
Journal: Annals of Internal Medicine (2005)

Background: Weight loss and increased physical exercise reduce the risk for diabetes in people with impaired glucose tolerance. Randomized trial evidence on the effect of these interventions on people without impaired glucose tolerance is lacking. Objective: To examine the influence of a comprehensive intervention program on the risk for developing diabetes in men without impaired glucose tolerance and in a post hoc subgroup analysis by baseline cigarette smoking status. Design: Randomized, controlled trial. Setting: 22 clinical centers for the Multiple Risk Factor Intervention Trial (MRFIT). Participants: 12 866 men age 35 to 57 years at risk for cardiovascular disease were randomly assigned to either a special intervention or usual care group and followed for 6 to 7 years; this report focuses on 11 827 men without diabetes or impaired glucose tolerance at entry for whom follow-up glucose measurements were available. Measurements: Cardiovascular disease risk factors, fasting blood glucose levels, and diabetes medication history were assessed before randomization and annually. Intervention: Men in the special intervention group were counseled to change diet (reduce saturated fat, cholesterol, and calorie intake), to stop smoking, and to increase physical activity. Blood pressure was treated more intensively in the special intervention group than in the usual care group. Results: 11.5% of the special intervention group and 10.8% of the usual care group developed diabetes over 6 years of follow-up (hazard ratio, 1.08 [95% CI, 0.96 to 1.20]). The special intervention–usual care hazard ratio for diabetes was 1.26 (CI, 1.10 to 1.45) among smokers (63%) and 0.82 (CI, 0.68 to 0.98) among nonsmokers (37%). These estimates differed significantly (P = 0.0003). Weight gain after smoking cessation and the use of antihypertensive drugs may have counterbalanced the beneficial effect of the lifestyle intervention for the special intervention group smokers, while the lifestyle intervention was beneficial among nonsmokers. Limitations: Principal findings are based on a post hoc subgroup analysis. Conclusions: In nonsmokers, an intervention program that included nutrition counseling to produce reductions in weight, serum cholesterol, and (along with antihypertensive medication) blood pressure reduced the risk for diabetes. *For a complete list of Multiple Risk Factor Intervention Trial investigators, see the following: Multiple risk factor intervention trial. Risk factor changes and mortality results. Multiple Risk Factor Intervention Trial Research Group. JAMA. 1982;248:1465-77. [PMID: 7050440]
Abstract 3774: A Novel Protein Phosphatase in SR Calcium and Cardiac Contractile Regulation
Authors: Hongmei Ruan, Gang Lu, Yibin Wang
Journal: Circulation (2008)

Loss of contractility is a common feature in heart failure. Sarcoplasmic Reticulum (SR) calcium cycling defect is a major mechanism underlying contractile dysfunction. Phospholamban (PLB) mediated regulation of SERCA activity in normal and failing heart plays an important role in SR calcium cycling. Recently, we discovered a novel isoform of protein phosphatase 2C family (PP2Ce) which is specifically targeted on ER membrane. Northern-blot showed that PP2Ce is highly expressed in heart and other tissue. Expression of PP2Ce in neonatal cardiomyocytes significantly repressed the PLB phosphorylation at the Thr-17 site without remarkable effect on Ser-16 site, which indicating its potent and very specific activity towards the Thr-17 site instead of the Ser-16 site of PLB in cardiomyocytes. By using an inducible a-MHC-in-PP2Ce construct and the Tet-expresser transgenic line, we developed a cardiac specific PP2Ce transgenic mice. PP2Ce expression was remarkably higher in transgenic hearts compared with control, accompanying with the increase in expression of phosphor-CaMKII. There were no significant difference in the cardiac function at basal based on Echocardiography measurements. Expression of PP2Ce markedly delayed the decay of calcium transients with the administration isoproterenol in isolated adult cardiomyocytes and blunted positive inotropic response in transgenic mice heart. In response to ISO treatment, PLB phosphorylation at the Thr-17 site were significantly suppressed in PP2Ce cardaiomyocytes and hearts, while there is no much change at Ser-16 site compared with controls. Our results suggested that PP2Ce may be a novel component of the PLB/SR calcium regulatory machinery involved in cardiac contractile regulation under physiological and pathological conditions and offer new insights to cardiac contractile regulation and failure. This research has received full or partial funding support from the American Heart Association, AHA National Center.
Fortnightly review: Anticoagulation in heart disease
Authors: S. M C Hardman, M. R Cowie
Journal: BMJ (1999)

Thromboembolism is a common complication of heart disease. The decision to prescribe an anticoagulant to prevent thromboemboli should be based on a particular patient's risk without treatment and the likely benefit and side effects of the proposed treatment. In this article we will discuss the use of warfarin and heparin in patients with heart disease.

#### Summary points

This review article is based on our chapter in Current Issues in Cardiology , which was subject to formal peer review and published in 1997.1 We undertook a full Medline search in each of the relevant subjects. We also sought references from recent papers, editorials, and review articles. When a choice was available we chose large well conducted double blind randomised trials, but we included observational series when they were the only available evidence.

Atrial fibrillation is not benign and is the commonest cause of cardiogenic stroke (fig 1).2 Within the general population the best available estimates suggest a prevalence of 0.5% for those …
STUDIES IN PSYCHIC FATIGUE. I. PHYSIOLOGIC FINDINGS
Authors: B KISSIN, I JAFFE, P ROSENBLATT, C S BYRON, I FREIMAN
Journal: Annals of Internal Medicine (1957)

Excerpt Psychic fatigue is not a distinct clinical entity but is generally a symptom of some underlying psychiatric condition. The syndromes which result in psychic fatigue include, among others, a...
Regression of Radial Artery Wall Hypertrophy and Improvement of Carotid Artery Compliance After Long-Term Antihypertensive Treatment in Elderly Patients 11This study was supported by grants from the Institut National de la Santé et de la Recherche Médicale (INSERM) (Grant 494014), Paris; Laboratoires SERVIER; and the European Community (BIOMED), Brussels, Belgium.
Authors: Xavier Girerd, Cristina Giannattasio, Cyril Moulin, Michel Safar, Giuseppe Mancia, Stéphane Laurent
Journal: Journal of the American College of Cardiology (1998)
UPTAKE OF MIRACIL D BY CELLS OF SENSITIVE AND MIRACIL D-RESISTANT LINES OF MOUSE LEUKEMIA L1210.
Authors: Shirley D. Brindle, Erich Hirschberg, Paul R. Gross
Journal: Cancer Research (1964)

Summary  With the aid of a spectrophotometric method of assay for Miracil D, a comparison was made of the ability of cells of the parent sensitive line and of a Miracil D-resistant subline of leukemia L1210 to remove the drug from the suspending medium during incubation  in vitro .  The uptake of Miracil D by the cells was proportional to the initial concentration of drug per cell in the suspending medium and to the length of the incubation period. The incubation temperature was varied between 0° and 37° C. without affecting the extent of drug uptake by the cells; this suggests that this process is nonenzymatic.  There was no difference, under these various conditions, between the sensitive and Miracil D-resistant cells in their permeability to this agent. This finding eliminates one of the possible mechanisms of resistance of this tumor to Miracil D.
Ablative Fractional Carbon Dioxide Laser in the Treatment of Chronic, Posttraumatic, Lower-Extremity Ulcers in Elderly Patients
Authors: Tania J. Phillips, Laurel M. Morton, Nathan S. Uebelhoer, Jeffrey S. Dover
Journal: JAMA Dermatology (2015)

Treating posttraumatic lower extremity wounds can be challenging, especially in elderly patients. Recently, the use of fractional carbon dioxide laser has been shown to improve wound healing in scar-related wounds. We used this treatment modality in posttraumatic wounds that were slow to heal in 3 elderly patients. Each wound underwent one fractional carbon dioxide laser treatment. The wound base was treated at 30 mJ and 5% density. The entire wound edge and 1 to 2 cm into the normal surrounding skin were treated at 50 mJ and 5% density. One pass was completed at 150 Hz per treatment. Treatments were well tolerated with only mild discomfort. Each wound healed by 60% or greater within 3 weeks. No adverse events were reported aside from mild and transient erythema at site of treatment. Fractional carbon dioxide laser treatment appeared to accelerate healing in each of these posttraumatic wounds. It may be a helpful adjunct in nonhealing posttraumatic wounds.
Development of an oligonucleotide probe specific for Trichophytonrubrum
Authors: None El Fari, None Tietz, None Presber, None Sterry, None Gräser
Journal: British Journal of Dermatology (1999)

Journal Article Development of an oligonucleotide probe specific for Trichophytonrubrum Get access M. El Fari, M. El Fari Departments of Microbiology and Hygiene Dr El Fari E‐mail: elfari@charite.de Search for other works by this author on: Oxford Academic Google Scholar H-J. Tietz, H-J. Tietz Dermatology, Universitätsklinikum Charité‐Virchow, Humboldt Universität zu Berlin, Dorotheenstr. 96, D‐10117 Berlin, Germany Search for other works by this author on: Oxford Academic Google Scholar W. Presber, W. Presber Departments of Microbiology and Hygiene Search for other works by this author on: Oxford Academic Google Scholar W. Sterry, W. Sterry Dermatology, Universitätsklinikum Charité‐Virchow, Humboldt Universität zu Berlin, Dorotheenstr. 96, D‐10117 Berlin, Germany Search for other works by this author on: Oxford Academic Google Scholar Y. Gräser Y. Gräser Departments of Microbiology and Hygiene Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 141, Issue 2, 1 August 1999, Pages 240–245, https://doi.org/10.1046/j.1365-2133.1999.02971.x Published: 01 August 1999
Abstract 3635: Weight Loss Reverses Left Ventricular Structural Changes In Subjects With Severe Uncomplicated Obesity. A One year Follow Up Study.
Authors: Oliver J Rider, Jane M Francis, Mohammed K Ali, Monique R Robinson, Stefan Neubauer
Journal: Circulation (2007)

Objective Obesity has been linked to a spectrum of cardiovascular abnormalities from subclinical changes in cardiac structure to overt heart failure. Uncomplicated obesity (i.e. obesity without any other co-morbidity or cardiovascular risk factors) has been shown to cause increased LV mass and LV dilatation. Our hypothesis was that these changes are, at least in part, reversible following significant weight loss over one year. Method Forty-one obese (BMI 37.7 ± 7.4 SD) and 12 age, sex matched controls (BMI 21.6 ± 1.8 SD) with no identifiable cardiac risk factors underwent cardiac MR imaging for the assessment of LV Mass (g), LV end-diastolic volume (EDV; ml), stroke volume (SV; ml) and LV EF (%). Fourteen obese subjects underwent repeat imaging after a one year period of weight loss, averaging 14.6 ± 11.5 % total body weight. Results Obesity per se was associated with elevated LV mass (125 ± 27 vs 89 ± 23g; p&lt;0.001), LV mass indexed to height (74.4 ± 14.3 vs 52.3 ± 11.4g/m; p&lt;0.001) and EDV (147 ± 28 vs 119 ± 24 ml; p&lt;0.001). ESV and SV were also elevated in obesity (47 ± 12 vs 39 ± 12ml; p=0.05, and 100 ± 14 vs 80 ± 18 ml; p&lt;0.001, respectively). LV EF was similar between groups (p=0.83). After weight loss, there was a significant reduction in LV mass (by 16 ± 11g; 135 ± 31 vs 119 ± 28g; p&lt;0.001), LV mass indexed to height (76.4 ± 15.7 vs 68.9 ± 12 g/m; p&lt;0.001). EDV and ESV were significantly smaller after weight loss (146 ± 25 vs 133 ± 23 ml; p&lt;0.001, and 43 ± 12 vs 41 ± 10 ml; p&lt;0.001 respectively). LV EF and SV did not change significantly. Conclusion In subjects with obesity in the absence of identifiable cardiac risk factors, LV hypertrophy and LV dilatation were partially reversible after a one year period of weight loss.
Further Study of Blastomogenic Substances in the Human Body
Authors: H. E. Kleinenberg, S. A. Neufach, L. M. Schabad
Journal: Cancer Research (1941)

In January, 1937, Schabad (II) showed that benzol extracts of the liver of a patient who had died of cancer were carcinogenic when injected into mice. Malignant and benign tumors were produced at the site of injection or in a remote location. In 1938, Neufach and Schabad (9, lO) proved that a benzol extract of the bile of patients who had died of cancer likewise possessed a blastomogenic effect. Recently, in 1939 and 194o, Kleinenberg, Neufach, and Schabad (4, 5, 6) summarized the results of a large number of experiments aimed at studying the effect of extracts obtained from organs of patients who had died of cancer and from persons who had died of other diseases. The results showed that extracts of organs from patients dying of cancer produced a greater number of tumors than extracts of organs of persons dying of other causes. The presence of blastomogenic substances in the organs of patients who had died of malignant tumors was established by this work and the assumption was made that these substances found in the human body were of endogenic origin. These results were confirmed in 194o by des Ligneris (i), Hieger (2), Menke (7), Steiner (18), and Tanaka, whose report is included in a paper by Kinosita (3). Additional detailed accounts of methods of extraction and results of tests for carcinogenicity of the extracts have been published by Neufach (8, 9), and by Schabad (11-16).
Abstract 16756: Quantitative Coronary CT Angiography Demonstrates Increased Total Burden and Non-Calcified Plaque in Psoriasis
Authors: Nehal N Mehta, Karen Rodriguez, Amir Jahanshad, Balaji Natarajan, Parasuram Krishnamoorthy, Martin P Playford, Julia Doveikis, Mark A Ahlman, David A Bluemke
Journal: Circulation (2014)

Introduction: Coronary computed tomography angiography (CCTA) directly characterizes composition of plaque in coronary heart disease (CHD). Although the use of CCTA has been established in clinical CHD, no study to date has ever examined how psoriasis (PSO), a chronic inflammatory skin disease associated with increased risk for myocardial infarction (MI), affects CHD by CCTA. Therefore, our goal was to understand whether psoriasis increases CHD detected by CCTA and establishes CHD plaque characteristics compared to subjects with clinical coronary disease and healthy volunteers. Methods: Subjects with PSO (N=54), CHD (N=75) and healthy controls (N=5) underwent quantitative coronary CCTA imaging (Toshiba MDCT). Total coronary plaque was assessed using QAngioCT (Medis, Netherlands) as the total coronary artery wall volume. Furthermore, to better understand the determinants of CHD [total burden (TB) and non-calcified plaque burden (NCB)], we performed deep phenotyping for lipid markers including lipid particle size and numbers, HDL efflux, and metabolic parameters of insulin resistance such as Homeostasis Model Assessment-Insulin Resistance (HOMA-IR) in psoriasis. Results: Our study showed that PSO was associated with higher TB and NCB of CHD when compared to both CHD and control groups (See Table 1). These findings were robust to adjustment for CHD risk factors (Framingham risk score) and luminal density (TB β=7.6, p&lt;0.001 &amp; NCB β=5.1, p=0.001). NCB was strongly associated with BMI (β=0.38, p&lt;0.01), HDL efflux capacity (β=-10.9, p&lt;0.05) and insulin resistance estimated by HOMA-IR (β=0.53, p&lt;0.05) in psoriasis. Conclusions: This is the first study to show that psoriasis increases total burden of CHD which is non-calcified providing compelling evidence for the association between psoriasis and MI. Determinants of this NCB suggest focusing therapies on lipid and metabolic derangement in psoriasis may reduce this risk of future events.
Expansion of T cells expressing low CD4 or CD8 levels in B-cell chronic lymphocytic leukemia: correlation with disease status and neoplastic phenotype
Authors: U Dianzani, P Omede, F Marmont, D DiFranco, A Fusaro, M Bragardo, V Redoglia, F Giaretta, L Mairone, M Boccadoro
Journal: Blood (1994)