tbuckley/cabot-search huggingface dataset:
U-500 Regular Insulin
Authors: ELLIOTT CHIDECKEL
Journal: Annals of Internal Medicine (1981)

Letters and Corrections1 September 1981U-500 Regular InsulinELLIOTT CHIDECKEL, M.D.ELLIOTT CHIDECKEL, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-95-3-389 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: Nathan and colleagues (1) have described three patients who were resistant to the euglycemic effect of U-100 NPH insulin (both mixed species and pork) but who responded to U-500 regular insulin (pork). They claim that U-500 regular insulin may be effective when U-100 NPH and U-100 regular insulin are ineffective. I believe that the authors never gave U-100 regular insulin a chance. In any stable period, none of the patients received doses of U-100 regular insulin equal to those of the U-500 insulin. Therefore, the U-500 cannot be claimed to be a superior regular insulin in these...Reference1. NATHANAXELRODFLIERCARR DLJD. U-500 insulin in the treatment of antibody-mediated insulin resistance. Ann Intern Med. 1981:94:653-6. LinkGoogle Scholar1. NATHANAXELRODFLIERCARR DLJD. U-500 insulin in the treatment of antibody-mediated insulin resistance. Ann Intern Med. 1981;94:653-6. LinkGoogle Scholar2. FLIERKAHNROTH JCJ. Receptors, antireceptor antibodies, and mechanisms of insulin resistance. N Engl J Med. 1979;300:413-9. CrossrefMedlineGoogle Scholar1. NATHANAXELRODFLIERCARR DLJD. U-500 insulin in the treatment of antibody-mediated insulin resistance. Ann Intern Med. 1981;94:653-6. LinkGoogle Scholar2. BLUNDELLDODSONHODGKINMEROLA TGDD. Insulin: the structure in the crystal and its reflection in chemistry and biology. Adv Protein Chem. 1972;26:279-402. CrossrefGoogle Scholar3. CZECH M. Insulin action. Am J Med. 1981;70:142-50. CrossrefMedlineGoogle Scholar4. SCHLESSINGERVAN OBBERGHENKAHN JEC. Insulin and antibodies against the insulin receptor cap on the membrane of cultured human lymphocytes. Nature. 1980;286:729-31. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: West Virginia University Hospital Morgantown, WV 26506 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 September 1981Volume 95, Issue 3Page: 389-390KeywordsInsulin Issue Published: 1 September 1981 PDF DownloadLoading ...
Safeguarding Nonhuman Primate iPS Cells With Suicide Genes
Authors: Bonan Zhong, Korashon L Watts, Jennifer L Gori, Martin E Wohlfahrt, Joerg Enssle, Jennifer E Adair, Hans-Peter Kiem
Journal: Molecular Therapy (2011)

The development of technology to generate induced pluripotent stem (iPS) cells constitutes one of the most exciting scientific breakthroughs because of the enormous potential for regenerative medicine. However, the safety of iPS cell-related products is a major concern for clinical translation. Insertional mutagenesis, possible oncogenic transformation of iPS cells or their derivatives, or the contamination of differentiated iPS cells with undifferentiated cells, resulting in the formation of teratomas, have remained considerable obstacles. Here, we demonstrate the utility of suicide genes to safeguard iPS cells and their derivatives. We found suicide genes can control the cell fate of iPS cells in vitro and in vivo without interfering with their pluripotency and self-renewal capacity. This study will be useful to evaluate the safety of iPS cell technology in a clinically highly relevant, large animal model and further benefit the clinical use of human iPS cells. The development of technology to generate induced pluripotent stem (iPS) cells constitutes one of the most exciting scientific breakthroughs because of the enormous potential for regenerative medicine. However, the safety of iPS cell-related products is a major concern for clinical translation. Insertional mutagenesis, possible oncogenic transformation of iPS cells or their derivatives, or the contamination of differentiated iPS cells with undifferentiated cells, resulting in the formation of teratomas, have remained considerable obstacles. Here, we demonstrate the utility of suicide genes to safeguard iPS cells and their derivatives. We found suicide genes can control the cell fate of iPS cells in vitro and in vivo without interfering with their pluripotency and self-renewal capacity. This study will be useful to evaluate the safety of iPS cell technology in a clinically highly relevant, large animal model and further benefit the clinical use of human iPS cells.
Abstract 2015: Effect of valproic acid on fludarabine activity in chronic lymphocytic leukemia patients
Authors: Ju-Yoon Yoon, David Szwajcer, Ishdorj Ganchimeg, Pat Benjaminson, James Johnston, Spencer Gibson
Journal: Cancer Research (2011)

Abstract Valproic acid (VPA) is a first-generation anti-epileptic drug that has been shown to inhibit proliferation and induce apoptosis in various hematological malignancies, including multiple myeloma and chronic lymphocytic leukemia (CLL). We show here that the mechanism of VPA-induced apoptosis in CLL is associated with activation of the TNF-related apoptosis-inducing ligand (TRAIL) apoptotic pathway in vitro and in vivo. Treatment of leukemic cell lines or primary CLL cells with VPA increased the level of TRAIL receptor 1 (TRAIL-R1), but not TRAIL-R2, and upregulated the TRAIL pathway in vitro, resulting in increased casepase-8 cleavage. Treatment with VPA also induced formation of reactive oxygen species (ROS), and the combined cytotoxicity of VPA and fludarabine was dampened upon co-treatment with a ROS scavenger, N-acetylcysteine. Having shown the effects of VPA in vitro, a phase II clinical trial was initiated at CancerCare Manitoba to determine the activity of VPA in CLL, either when used alone or in combination with fludarabine. Five patients who had received at least one prior therapy with fludarabine have to date been examined. Three out of 5 patients were fludarabine-resistant, as defined as no response to fludarabine or relapse &amp;lt;6 months after completion of treatment with fludarabine. No responses were seen after 28 days using VPA alone. However, in four patients who continued on VPA with fludarabine, 3 patients showed a &amp;gt;50% fall in lymphocyte/lymph node size after receiving 5 cycles of the combination. Peripheral blood samples were obtained prior to each treatment cycle, and mononuclear cells were isolated for analysis by immunoblotting and immunocytochemistry. Levels of both histone 3-acetyl and histone 4-acetyl initially increased and then fluctuated during the course of treatment. TRAIL-R1 levels increased during the course of therapy, while no significant changes in TRAIL-R2 levels were observed. Expression of mRNA levels of genes involved in apoptosis was examined in one patient before and 28 days following VPA. There was a global up-regulation of both pro- and anti-apoptotic genes (as categorized by their gene ontology) which likely explains the effect of VPA on fludarabine sensitivity in CLL. In summary, VPA induces hyper-acetylation of histones in CLL and activates the TRAIL apoptotic pathway. While VPA is ineffective as a single agent in CLL, it can sensitize CLL cells to fludarabine and could be used as an adjuvant in fludarabine-based treatment regimens. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 102nd Annual Meeting of the American Association for Cancer Research; 2011 Apr 2-6; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2011;71(8 Suppl):Abstract nr 2015. doi:10.1158/1538-7445.AM2011-2015
Poisonous Snakebite Treatment in the United States
Authors: Charles H. Watt
Journal: JAMA (1978)

This is retrospective report of 107 cases of poisonous snakebites treated in south Georgia and north Florida. Sixty-seven percent of the cases required intensive treatment. Intravenous antivenin therapy, if indicated, should be given early and over a short time. Steroids are of use primarily for allergic phenomena. Fasciotomies were not necessary unless cooling or inadequate antivenin had been administered. A grading system that matches the species of snake with the severity of the bite was used to classify the cases.
Image-guided drug delivery with magnetic resonance guided high intensity focused ultrasound and temperature sensitive liposomes in a rabbit Vx2 tumor model
Authors: Ashish Ranjan, Genevieve C. Jacobs, David L. Woods, Ayele H. Negussie, Ari Partanen, Pavel S. Yarmolenko, Carmen E. Gacchina, Karun V. Sharma, Victor Frenkel, Bradford J. Wood, Matthew R. Dreher
Journal: Journal of Controlled Release (2011)
Changing Patterns in the Practice of Carotid Endarterectomy in a Large Metropolitan Area
Authors: Joseph M. Graham
Journal: JAMA (1986)

To the Editor.—  As a vascular surgical specialist, I was dismayed to read of the changing patterns in the practice of carotid endarterectomy in the Cincinnati area, as outlined by Brott et al. 1   Of particular concern for all of us practicing good vascular surgery with acceptable stoke and mortality rates was the fact that this article was picked up by the national news service and widely publicized as representative of the results of carotid endarterectomy as a preventative measure for embolic stroke.  The 74% increase in carotid endarterectomies between 1980 and 1984 is probably accurate as a trend throughout the country. This reflects an increasing awareness of the etiologic role of atheromatous emboli from the carotid bifurcation and the ease with which these lesions can now be diagnosed and screened using noninvasive and Doppler imaging studies. In addition, willingness on the part of patients to have the operations and
'Is it Proper for Consumptives to Marry?'
Authors: C. J. B. Williams
Journal: BMJ (1871)

The Professor concluded his lecture by the narration of a very inter- esting case of eczema exfoliativum which he had at present under treat- ment; this case was accompanied with all the symptoms already detailed, and, in addition, with loss of the nails and loss of the hair.The patient was a man of gouty diathesis, and was also the subject of lepra vulgaris."IS IT PROPER FOR CONSUMPTIVES TO MARRY ?"
Cutaneous embolization of cardiac myxoma
Authors: M.J. Garcia-F-Villalta, T. Sanz-Sanchez, M. Aragues, A. Blasco, J. Fraga, A. Garcia-Diez
Journal: British Journal of Dermatology (2002)

Summary Atrial myxoma is the most common primary tumour of the heart. Skin manifestations in patients with a cardiac myxoma are frequent and may be due to cutaneous emboli, or may be specific findings as part of more complex syndromes. We present a 33‐year‐old‐man with a history of episodes of pain in both legs and an ischaemic neurological event, who also had episodes of acral papular erythematous lesions on the legs and feet including the soles. The histological finding of dermal vessels occluded by a myxomatous material was the clue to the diagnosis of a cardiac myxoma. The diagnosis of this entity can be very difficult, because of the broad spectrum of clinical features; rarely the skin manifestations lead to the diagnosis of this tumour. The histological recognition of the myxomatous emboli is of vital importance for the diagnosis and treatment of this disease.
Safety and Reproducibility of Sputum Induction in Asthmatic Subjects in a Multicenter Study
Authors: JOHN V. FAHY, HOMER A. BOUSHEY, STEPHEN C. LAZARUS, ELIZABETH A. MAUGER, REUBEN M. CHERNIACK, VERNON M. CHINCHILLI, TIMOTHY J. CRAIG, JEFFREY M. DRAZEN, JEAN G. FORD, JAMES E. FISH, ELLIOT ISRAEL, MONICA KRAFT, ROBERT F. LEMANSKE, RICHARD J. MARTIN, DIANE McLEAN, STEPHEN P. PETERS, CHRISTINE SORKNESS, STANLEY J. SZEFLER
Journal: American Journal of Respiratory and Critical Care Medicine (2001)

The safety of sputum induction and the reproducibility of measurements in induced sputum in multicenter studies is unknown. We examined the safety of sputum induction in a two-visit, six-center study in 79 subjects with moderate to severe asthma (mean ± SD FEV1 71 ± 12% predicted, 67% taking inhaled corticosteroids). In addition, we compared the reproducibility of markers of inflammation in induced sputum with the reproducibility of the FEV1 and the methacholine PC20. The FEV1 decreased ⩾ 20% from the postbronchodilator baseline in 14% of all subjects and in 25% of subjects whose initial prebronchodilator baseline was 40 to 60% of predicted. All subjects responded promptly to additional albuterol treatment, and no subject developed refractory bronchoconstriction requiring treatment other than reversal of bronchospasm in the study laboratory. The reproducibility of measurements of the eosinophil percentage, eosinophil cationic protein, tryptase, and methacholine PC20 were similar (concordance correlation coefficients of 0.74, 0.81, 0.79, and 0.74, respectively), without any significant among-center effect. We conclude that sputum induction can be performed safely in subjects with moderate to severe asthma in multicenter clinical trials when carried out under carefully monitored conditions. Importantly, we demonstrate that measurement of markers of inflammation in induced sputum is as reproducible as methacholine PC20 and should prove useful in the assessment of airway inflammation in multicenter clinical trials.
Hyponatraemia and Bronchial Carcinoma: Therapy with Nitrogen Mustard
Authors: A. L. Linton, I. Hutton
Journal: BMJ (1965)

serving in the R.A.F., so that it would appear that this boy's basic personality may well have developed into a reasonably adequate one. COMMENTAs only 15 cases of addiction to petrol inhalation have been described in 13 years the position should not give undue cause for alarm.Among the 15 cases were two 6-year-olds (Pruitt, 1959; Edwards, 1960).The effect of sniffing petrol was dis- covered by chance in every instance.The habit continued for many years in a number of cases, and then when it came to light it was because of vivid hallucinatory experiences.The hallucinations described here were of foxes, while Tolan and Lingl (1964) report the case of an adolescent boy who saw billions of ants.The addiction can be the cause of a sudden attack of unconsciousness, and can end in tragedy-death due to liver and renal necrosis.The relief of tension would appear to have been the reason for the beginning of the habit in all the cases that have been reported.
Lymphocyte Transformation during Dinitrochlorobenzene Contact Sensitization. AN IN VITRO AND IN VIVO EVALUATION OF THE PRIMARY IMMUNE RESPONSE IN MAN
Authors: A. Edgar Miller, William R. Levis
Journal: Journal of Clinical Investigation (1973)

An evaluation of cell-mediated immunity in man is described that combines the advantages of an in vitro technique, lymphocyte transformation, with the use of contact sensitization to a primary immunogen, dinitrochlorobenzene (DNCB). DNCB, when coupled to autologous or allogeneic peripheral blood leukocytes, forms a complex, DNCB-antigen, that induces lymphocyte transformation specifically in leukocyte cultures from subjects sensitized to DNCB. Sequential studies of lymphocyte transformation to DNCB-antigen show that specifically reactive lymphocytes are first detected at about 10 days after in vivo application of a sensitizing dose of DNCB and reach a peak at about 14-21 days.
Hospice Effect on Medicare Expenditures
Authors: Pedro Gozalo, Vince Mor, Susan Miller
Journal: Annals of Internal Medicine (2004)

Letters7 September 2004Hospice Effect on Medicare ExpendituresPedro Gozalo, PhD, MSc, Vince Mor, PhD, and Susan Miller, PhD, MBAPedro Gozalo, PhD, MScFrom Brown University, Providence, RI 02912.Search for more papers by this author, Vince Mor, PhDFrom Brown University, Providence, RI 02912.Search for more papers by this author, and Susan Miller, PhD, MBAFrom Brown University, Providence, RI 02912.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-141-5-200409070-00029 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:The interesting study by Campbell and colleagues (1) confirmed much previous research on the cost of hospice versus nonhospice care to the Medicare program. It also documented the decade-long shift in the mix of hospice beneficiaries from cancer to noncancer diagnoses and from the younger elderly to the oldest old, particularly those residing in nursing homes. The authors found that the savings hospice achieves by avoiding terminal hospitalizations among patients with cancer are offset by additional hospice services provided to older patients and patients without cancer who use fewer hospital resources. Aggregate added costs due to hospice ...References1. Campbell DE, Lynn J, Louis TA, Shugarman LR. Medicare program expenditures associated with hospice use. Ann Intern Med. 2004;140:269-77. [PMID: 14970150] LinkGoogle Scholar2. Miller SC, Intrator O, Gozalo P, Roy J, Barber J, Mor V. Government expenditures at the end of life for short- and long-stay nursing home residents: differences by hospice enrollment status. J Am Geriatr Soc. 2004;52:1284-92. [PMID: 15271115] CrossrefMedlineGoogle Scholar Author, Article, and Disclosure InformationAffiliations: From Brown University, Providence, RI 02912. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoMedicare Program Expenditures Associated with Hospice Use Diane E. Campbell , Joanne Lynn , Tom A. Louis , and Lisa R. Shugarman Hospice Effect on Medicare Expenditures Diane Campbell , Joanne Lynn , and Lisa R. Shugarman Metrics 7 September 2004Volume 141, Issue 5Page: 409-410KeywordsElderlyHospitalizationsMedicareNursing homesStatistical distributionsStatistical models ePublished: 7 September 2004 Issue Published: 7 September 2004 CopyrightCopyright © 2004 by American College of Physicians. All Rights Reserved.PDF DownloadLoading ...
Value of pulsus paradoxus in assessing acute severe asthma. British Thoracic Society Standards of Care Committee.
Authors: M G Pearson, D P Spence, I Ryland, B D Harrison
Journal: BMJ (1993)

or less failed to meet this standard's requirement that generic names and dose should be 1P5 mm or more and 10 out of 11 ampoules of greater than 2 ml failed to meet its minimum of 2-5 mm.We believe that a British standard for size and clarity of drug ampoule labels is urgently required.1 Ananthanaryan C. Similarity between ephedrine and atropine ampules.
I'll Take Tomorrow: The Story of a Courageous Woman Who Dared to Subject Herself to a Medical Experiment—The First Successful Heart-Lung Transplant
Authors: Robert Lanza
Journal: JAMA (1985)

<i>I'll Take Tomorrow</i>is the fascinating autobiographical story of Mary Gohlke, the first long-term survivor of a heart-lung transplant. It is the chronicle of her discovery that she was dying of primary pulmonary hypertension and of the day-to-day events leading up to and following her historic operation. The author—wife, mother, and advertising executive— shares her physical, emotional, and mental struggle with the fantastic problems that are associated with successful cardiopulmonary transplantation, from organ rejection to behavioral disturbances and the need to readjust to family relationships and employment. Faced with the choice between certain death and another chance for life, Gohlke chose to subject herself to a dramatic experimental procedure. During her journey back to health, her optimism gave way at times to anxiety, despair, and even depression. Her moving account reminds us of just how taxing living with a transplanted organ can be. The book is filled with emotion and
RADIOLOGICAL EVALUATION AND INVESTIGATION WITH X-RAY CT AND MRI FINDINGS IN PATIENTS WITH SPINAL TRAUMA DURING PROFESSIONAL AND AMATEUR SPORT ACTIVITIES
Authors: N Syrmos, A Mylonas, G Gavridakis, K Grigoriou, V Valadakis, C Iliadis, D Arvanitakis
Journal: British Journal of Sports Medicine (2013)

Background Radiological evaluation is very important in spinal trauma patients, specially during sport activity. Aim Aim of this study was to analyze the type of sport activity, the timing of injury, the radiological evaluation and the role of X-Ray, CT and MRI findings in 40 patients with spinal trauma during sport activities (amateur and professional). Material/Methods During a five year period (2005–2009) we analyzed 40 patients with spinal trauma during sports activity. 35 male (87.5%) and 5 female(12.5%), range 14–64 years, mean age 39.5 years. Results We analyzed first the type of sport activity, amateur (group a, thirty patients 75%) professional (group b, ten patients, 25%), then the timing of injury, recent trauma (group 1, twenty-five patients 62.5%) and chronic trauma, more than 10 days after the initial injury (group 2, fifteen patients, 37.5%) and the radiological investigation, only X-ray and ctscan (group I, four patients, 10%), X-ray, CT scan, MRI scan (group II, thirty-six patients, 90%). We found three intramedullary hematomas, two intramedullary contusions, one epidural hematoma, five vertebral fractures, four facet joints dislocations, three herniated discs. Conclusions The MRI investigation was very helpful to find four sclerotic post traumatic bone changes and one medullary transection. Further studies were warranted but the combination of CT and MRI is is very useful tool for the evaluation, for the therapeutic approach and for the final result in patients with spinal trauma.
The Distinguished Services of Claude E. Welch, M.D.
Authors: F.J. Ingelfinger
Journal: New England Journal of Medicine (1976)

The Distinguished Service Award of the American Medical Association, the Association's highest honor, is given for meritorious service in the science and art of medicine. The list of past awardees includes such out standing physician exponents of this art and science as James B. Herrick, Elliott Joslin, George Minot, Evarts Graham, Paul Dudley White, Alfred Blalock, Michael DeBakey, Lester Dragstedt, Irvine Page, Tinsley Harrison and George Whipple. Once it was given to a non-physician, Anton J. Carlson. The recipient of the Award this year was Claude Emerson Welch, M.D.The presentation of the Award to Claude Welch made The New . . .