MALABSORPTION SYNDROME: INTESTINAL ABSORPTION OF VITAMIN B_12
Authors: S OXENHORN, S ESTREN, L R WASSERMAN, D ADLERSBERG
Journal: Annals of Internal Medicine (1958)

Article1 January 1958MALABSORPTION SYNDROME: INTESTINAL ABSORPTION OF VITAMIN B12SANFORD OXENHORN, M.D., SOLOMON ESTREN, M.D., LOUIS R. WASSERMAN, M.D., F.A.C.P., DAVID ADLERSBERG, M.D., F.A.C.P.SANFORD OXENHORN, M.D., SOLOMON ESTREN, M.D., LOUIS R. WASSERMAN, M.D., F.A.C.P., DAVID ADLERSBERG, M.D., F.A.C.P.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-48-1-30 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe common denominator of the clinical entities variously known as non-tropical sprue, tropical sprue, celiac disease and idiopathic steatorrhea is impaired intestinal absorption of various dietary substances. The etiology of these syndromes is not known, but evidence for a hereditary predisposition as well as environmental factors has been documented. In the broader view of today, these several clinical entities may be grouped together under the term "malabsorption syndrome" and considered a complex metabolic disorder, the focal point of which is disturbed intestinal absorption.1In addition to primary malabsorption syndrome, somewhat similar clinical pictures may be seen in intestinal resection, blind...Bibliography1. Adlersberg D: Introduction to symposium on the malabsorption syndrome, J. Mt. Sinai Hosp. 24: 177, 1957. MedlineGoogle Scholar2. Estren S: The blood and bone marrow in idiopathic sprue, J. Mt. Sinai Hosp. 24: 304, 1957. MedlineGoogle Scholar3. Innes EM: The blood and bone marrow in the sprue syndrome. A study of 63 cases, Edinburgh M. J. 55: 282, 1948. MedlineGoogle Scholar4. BossakWangAdlersberg ETCID: Clinical aspect of malabsorption syndrome, J. Mt. Sinai Hosp. 24: 286, 1957. MedlineGoogle Scholar5. OxenhornEstrenAdlersberg SSD: Intestinal uptake of vitamin B12 in the malabsorption syndrome, J. Mt. Sinai Hosp. 24: 232, 1957. MedlineGoogle Scholar6. Schilling RF: Intrinsic factor studies. II. The effect of gastric juice on the urinary excretion of radioactivity after the oral administration of radioactive vitamin B12 , J. Lab. and Clin. Med. 42: 860, 1953. MedlineGoogle Scholar7. CallenderEvans STJR: The biochemistry of vitamin B12 , 1955, Cambridge University Press, London, p. 68. Google Scholar8. LopezMilanesSpiesTocaAramburuLopez GGFTDRLTH: The association of hypoproteinemia with severe tropical sprue, Am. J. M. Sc. 218: 660, 1949. (a) Adlersberg, D., Wang, C., and Bossak, E.: Disturbances in protein and lipid metabolism in malabsorption syndrome, J. Mt. Sinai Hosp. 24: 206, 1957. CrossrefMedlineGoogle Scholar9. MillerRhoads DKCP: The experimental production of loss of hematopoietic elements of the gastric section and of the liver in swine with achlorhydria and anemia, J. Clin. Investigation 14: 153, 1935. CrossrefMedlineGoogle Scholar10. Aschkenasy A: On the pathogenesis of anemias and leukopenias induced by dietary protein deficiency, Am. J. Clin. Nutrition 5: 14, 1957. CrossrefMedlineGoogle Scholar11. FauvertHartmannGuénin RCP: Le retentissement hématologique des gastrectomies. L'anémie protéiprive. Etude de 110 cas de gastrectomies. Symposium sur les anémies dites de nutrition, Sang 23: 745, 1952. MedlineGoogle Scholar12. Girdwood RH: A folic acid excretion test in the investigation of intestinal absorption, Lancet 1: 53, 1953. CrossrefGoogle Scholar13. CohenMeyerFadem BSLMR: Sprue refractory to vitamin B12; satisfactory response to folic acid, Ann. Int. Med. 36: 1533, 1952. LinkGoogle Scholar14. IsraelsSharp MCJ: Idiopathic steatorrhoea (non-tropical sprue) with megaloblastic anaemia, Lancet 1: 752, 1950. CrossrefMedlineGoogle Scholar15. TuckWhittaker IMN: Vitamin B12 in idiopathic steatorrhoea, Lancet 1: 757, 1950. CrossrefMedlineGoogle Scholar16. MollinRoss DLGI: Serum vitamin B12 concentrations of patients with megaloblastic anaemia after treatment with vitamin B12, folic acid, or folinic acid, Brit. M. J. 2: 640, 1953. CrossrefMedlineGoogle Scholar17. MuellerHawkinsVilter JFVRRW: Liver extract refractory megaloblastic anemia, Blood 4: 1117, 1949. CrossrefMedlineGoogle Scholar18. Bjorkenheim G: Neurological changes in pernicious tapeworm anaemia, Acta med. Scandinav., Suppl. 260: 1-124, 1951. Google Scholar19. HalstedSwendseidLewisGasster JAMEPMM: Mechanisms involved in the development of vitamin B12 deficiency, Gastroenterology 30: 21, 1956. CrossrefMedlineGoogle Scholar20. MollinRoss DLGI: Vitamin B12 deficiency in the megaloblastic anemias, Proc. Roy. Soc. Med. 47: 428, 1954. MedlineGoogle Scholar21. MeynellCookeCoxGaddie MSWTEVR: Serum cyanocobalamin level in chronic intestinal disorders, Lancet 1: 901, 1957. CrossrefGoogle Scholar22. BoothMollin CCDL: Plasma, tissue and urinary radioactivity after oral administration of Co56 co-labelled vitamin B12 , Brit. J. Haematol. 2: 223, 1956. CrossrefMedlineGoogle Scholar23. RossMollinCoxUngley GIDLEVCC: Hematologic responses and concentration of vitamin B12 in serum and urine following oral administration of vitamin B12 without intrinsic factor, Blood 9: 473-488 (May) 1954. CrossrefMedlineGoogle Scholar24. CallenderEvans STJR: Observations on the relationship of intrinsic factor to the absorption of labelled vitamin B12 from the intestine, Clin. Sc. 14: 387, 1955. MedlineGoogle Scholar25. ReisnerGilbertRosenblumMorgan EHJPCMC: Applications of the urinary tracer test (of Schilling) as an index of vitamin B12 absorption, Am. J. Clin. Nutrition 4: 134, 1956. CrossrefMedlineGoogle Scholar26. Glass GB: Intestinal absorption and hepatic uptake of vitamin B12 in diseases of the gastrointestinal tract, Gastroenterology 30: 37, 1956. CrossrefMedlineGoogle Scholar27. KrevansConleySachs JRCLM: Influence of certain diseases on the absorption of vitamin B12 from the gastrointestinal tract, J. Clin. Investigation 33: 949, 1954. Google Scholar28. BestWhiteLouisLimarzi WRWFJLR: Experiences with the Schilling test using Co60-labelled vitamin B12 in pernicious anemia, sprue and other conditions, J. Lab. and Clin. Med. 44: 767, 1954. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: New York, N. Y.*From the Symposium on Diseases of Intestinal Absorption, presented (in part) at the Thirty-eighth Annual Session of The American College of Physicians, Boston, Massachusetts, April 9, 1957.From the Departments of Medicine and Hematology, The Mount Sinai Hospital, New York, N. Y.†These studies were supported in part by the Albert A. List, Frederick Machlin and Anna Ruth Lowenberg Research Funds; and by grants from Squibb Institute for Medical Research, New Brunswick, New Jersey, and Merck and Company, Rahway, New Jersey.Requests for reprints should be addressed to David Adlersberg, M.D., The Mount Sinai Hospital, New York 29, N. Y. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byAnemia in the Orthopedic Patient: A Diagnostic ApproachNutritional Anemias Overview; Megaloblastic AnemiasReduced Absorption of Vitamin B12 in Two Patients with Folic Acid DeficiencyROBERT B. SCOTT, M.D., F.A.C.P., ROBERT B. KAMMER, M.D., WILBUR F. BURGER, M.D., FRANCIS G. MIDDLETON, M.D.Coeliac DiseaseNutrition in Relation to the AnemiasTransient Selective Vitamin B12 Malabsorption in an AdultWALTER J. HOGAN, M.D., KONRAD H. SOERGEL, M.D., SARA B. ARNAUD, M.D.The Malabsorption Syndrome, with Special Reference to The Effects of Wheat GlutenDer Vitamin B12-Stoffwechsel und seine StörungenTropical Sprue and Vitamin B 12Co58B12 absorption (hepatic surface count) after gastrectomy, ileal resection, and in coeliac disordersAbsorption of vitamin B12 in nutritional megaloblastic anaemiaRadio-Vitamin B12 in der klinischen DiagnostikInhibition of Experimental Hypercholesterolemia and Atherogenesis by 4-Amino Pteroylglutamic Acid (Aminopterin)JEJUNAL BIOPSY IN ADULT CŒLIAC DISEASE AND ALLIED DISORDERSPhysiology and Pathology of Vitamin B12 Absorption, Distribution, and ExcretionRadioactive Fat Absorption and Clinical Response of Sprue to Steroid TherapyMassive Intestinal ResectionNutritional anemias with especial reference to vitamin B12Isotopes in Absorption Studies 1 January 1958Volume 48, Issue 1Page: 30-38KeywordsCeliac diseaseEtiologyExcretionHematology and oncologyHospital medicineIngestionMegaloblastic anemiaMetabolic disordersResearch funding Issue Published: 1 January 1958 PDF downloadLoading ...