tbuckley/cabot-search huggingface dataset:
THE EFFECT OF CERTAIN ANTACIDS IN MAN MEASURED BY A SIMPLIFIED METHOD FOR THE CONTINUOUS RECORDING OF GASTRIC pH
Authors: N. E. Rossett, James Flexner
Journal: Annals of Internal Medicine (1944)

Article1 July 1944THE EFFECT OF CERTAIN ANTACIDS IN MAN MEASURED BY A SIMPLIFIED METHOD FOR THE CONTINUOUS RECORDING OF GASTRIC pHN. E. ROSSETT, M.D., JAMES FLEXNER, M.D.N. E. ROSSETT, M.D.Search for more papers by this author, JAMES FLEXNER, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-21-1-119 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptIn a previous communication1 we described a method for the continuous recording of gastric pH in man. At that time we were of the opinion that colloidal aluminum hydroxide† in 30 c.c. dosage made up to 200 c.c. with water, or 200 c.c. of milk alone, fulfilled the physiological criteria of an ideal antacid. It was also noted that the use of calcium carbonate or of magnesium salts caused a great initial rise in pH but that their buffering effect was of short duration.In the present study we have extended our observations on antacids with the use of an...Bibliography1. ROSSETTFLEXNER NEJ: A method for the continuous recording of gastric pH in situ. IV. Further evaluation of the efficacy of antacids in vitro and in the human being, ANN. INT. MED., 1943, xviii, 193. Google Scholar2. FLEXNERKNIAZUKNYBOER JMJ: A method for the continuous recording of gastric pH in situ, Science, 1939, xc, 239-240. CrossrefGoogle Scholar3. FLEXNERKNIAZUK JM: A method for the continuous recording of gastric pH in situ. II. Experimental details, Am. Jr. Digest. Dis., 1940, vii, 138-140. CrossrefGoogle Scholar4. FLEXNERKNIAZUK JM: A method for the continuous recording of gastric pH in situ. III. Evaluation of the efficacy of certain antacids, Am. Jr. Digest. Dis., 1941, viii, 45-47. CrossrefGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: New York, N. Y.*Received for publication February 1, 1943.From the Second (Cornell) Medical Division, Bellevue Hospital, New York, N. Y.†The preparation amphojel was used. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited bySyntheses and Evaluation of New High-Capacity Gastric Antacids IPreparation and Properties of New Gastric Antacids VPreparation and Properties of New Gastric Antacids I**Received September 2, 1959, from the Research Laboratory, Reheis Co., Inc., Berkeley Heights, N. J.Gastric Acid Rebound—A ReviewA Study of AntacidsPEPTIC ULCER: MEDICAL CURE BY EFFICIENT GASTRIC ACID NEUTRALIZATION*N. E. ROSSETT, M.D., F.A.C.P., F. H. KNOX JR., M.D., S. L. STEPHENSON JR., M.D.Antacid Efficacy in Vitro of Some Foods Commonly Used in Peptic Ulcer DietsColloidal aluminum hydroxidel gel and magnesium hydroxide in the management of peptic ulcers 1 July 1944Volume 21, Issue 1Page: 119-121KeywordsCalciumCarbonatesMagnesiumMilkSalts ePublished: 1 December 2008 Issue Published: 1 July 1944 PDF downloadLoading ...
Britain needs 1000 more GPs Mr Dobson warns on executive pay GMSC will issue guidance on primary care groups
Authors: Linda Beecham
Journal: BMJ (1998)

# Britain needs 1000 more GPs {#article-title-2}

The General Medical Services Committee says that Britain needs 1000 more GPs and has called on the government to work with the profession to make general practice more attractive.

At a conference in London last week the committee's chairman, Dr John Chisholm, said that the average GP worked a 62 hour week, with more than a quarter working more than 80 hours. Many list sizes were 600 above the national average and in some parts of Britain—for example, the south Wales valleys and parts of north east England—vacancies were left unfilled for 18 months to two years. In many areas—particularly some inner city areas—general practice had been kept afloat by the 3000 overseas born and trained doctors. Many of these, Dr Chisholm said, would retire in the next 15 years and there were insufficient young doctors to take their place.

“It is important that we take action now because all the figures are in the wrong direction,” the GMSC chairman told the meeting. Some steps were already being taken, such as the expansion of preregistration house officers in general practice and innovative developments in vocational training. But more attention had to be paid to …
Abstract 18499: Myocardial NADPH Oxidase 2 Overexpression Increases Atrial Fibrillation Susceptibility : Inhibition by Short Term Statin Treatment
Authors: Alice Recale, Ricardo Carnicer, Klemen Ziberna, Jillian Simon, Svetlana Reilly, Sander Verheule, Ajay M Shah, Barbara Casadei
Journal: Circulation (2014)

Introduction: Atrial fibrillation (AF) is associated with an increase in atrial oxidative stress. We have previously shown that a NOX2-containing NADPH oxidase (NOX2) is an important source of reactive oxygen species (ROS) in human atrial myocytes. Atrial NOX2 activity is increased early after pacing-induced AF in the goat and is an independent predictor of postoperative AF. Hypothesis: Is an increase in atrial NOX2 activity sufficient to generate a substrate for AF? Methods: We evaluated ECG parameters and AF inducibility (in response to burst pacing) in cardiomyocyte-specific NOX2 Tg mice. As statins inhibit NOX2 activity, we then repeated these investigations in NOX2 Tg and WT littermates that had been allocated to either atorvastatin (ATV 30 mg/kg/day) or placebo for 2 weeks. All measurements were carried out by investigators blind to genotype and treatment allocation. Results: NOX2 Tg mice showed a modest increase in myocardial NADPH stimulated superoxide production (+16% vs. WT, n=4/group, P<0.05). ...
Quality of life after coronary angioplasty or continued medical treatment for angina: three-year follow-up in the RITA-2 trial‡‡Participants of the second Randomized Intervention Treatment of Angina (RITA-2) trial are listed in the Appendix.
Authors: Stuart J Pocock, Robert A Henderson, Tim Clayton, Gary H Lyman, Douglas A Chamberlain
Journal: Journal of the American College of Cardiology (2000)
Abstract #4406: Hyperglycemia regulates RUNX2 activation and cellular wound healing through the aldose reductase polyol pathway
Authors: David D'Souza, Maryann Salib, Jessica Bennett, Maria Mochin-Peters, Kaushal Asrani, Simeon Goldblum, Keli Renoud, Antonino Passaniti
Journal: Cancer Research (2009)

Cancer cells are known to rely on glucose for energy in a process of aerobic glycolysis called the Warburg effect that is believed to contribute to tumor growth, survival, and metastasis. The IGFR/PI3K/Akt/mTOR pathway is important in this process because it activates Glut1,2 transporter-mediated glucose uptake and apoptotic resistance in transformed cells. Components of the microenvironment, such as tumor vessels, may also depend on glycolysis to provide the necessary nutrients and energy required for angiogenesis. Therefore, vascular endothelial cells (ECs) could be sensitive to the same anti-glycolytic strategies proposed for tumor cells. The RUNX2 transcription factor, which is expressed in metastatic tumor cells and ECs, promotes vascular EC migration, proliferation, and angiogenesis in response to IGF1/IGFR activation. Here we show that physiological levels of glucose (euglycemia) increase RUNX2 DNA binding and transcriptional activity, while hyperglycemia (HG) does not. The aldose reductase (AR) polyol pathway has been shown to mediate vascular damage in response to HG, but may also neutralize toxic aldehyde byproducts of increased metabolism and contribute to drug resistance in cancer cells. Pharmacologic or genetic inhibition of AR in ECs reversed the HG suppression of RUNX2. IGF-1 secretion and IGFR phosphorylation by autocrine IGF-1 occurred equally well in euglycemic or HG conditions, suggesting that reduced RUNX2 activity in HG was not due to altered IGF-1/IGFR activation. AR also negatively regulated RUNX2-dependent vascular remodeling in an EC wounded monolayer assay, which was reversed by specific AR inhibition in HG. These current data suggest that RUNX2 mediates normal vessel function at physiological levels of glucose while HG conditions increase AR, inhibit RUNX2 activation, and suppress vascular remodeling; therefore, drugs that inhibit the AR pathway and enhance RUNX2 expression might normalize tumor vasculature, allowing chemotherapeutic delivery and better therapeutic response.   Citation Information:  In: Proc Am Assoc Cancer Res; 2009 Apr 18-22; Denver, CO. Philadelphia (PA): AACR; 2009. Abstract nr 4406.
TRICHINOSIS: REPORT OF AN EPIDEMIC
Authors: Frederick H. Hathaway, Lamson Blaney
Journal: Annals of Internal Medicine (1947)

Article1 February 1947TRICHINOSIS: REPORT OF AN EPIDEMICFREDERICK H. HATHAWAY, LAMSON BLANEYFREDERICK H. HATHAWAYSearch for more papers by this author, LAMSON BLANEYSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-26-2-250 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTrichinosis is an acute disease usually occurring in man following the ingestion of pork products infested with the encysted larvae of the Nematode,Trichinella spiralis. The illness is characterized by fever, muscular pains, swollen eyelids, and a variable course, depending on the degree of infestation. The adult forms of the parasite (male and female) develop in the intestinal tract where the female deposits her eggs after penetrating the mucosa. In a few days the youngtrichinaenter the intestinal lymphatics and are then transported by the circulatory system to all parts of the body. Usually, the initial symptoms of the...Bibliography1. GOULD SE: An effective method for the control of trichinosis in the United States, Jr. Am. Med. Assoc., 1945, cxxix, 1251-1254. CrossrefGoogle Scholar2. DRAKEHAWKESWARREN EHRSM: An epidemic of trichinosis in Maine, Jr. Am. Med. Assoc., 1935, cv, 1340-1343. CrossrefGoogle Scholar3. FERENBAUGHSEGALSCHULZE TLLHA: A trichinosis epidemic of sixty-four cases, Jr. Am. Med. Assoc., 1938, cx, 1434-1436. CrossrefGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: *Received for publication June 27, 1946. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byTrichinosis A Point Source OutbreakDONALD G. POCOCK, M.D., F.A.C.P., PAUL R. SCHNURRENBERGER, D.V.M., ARTHUR D. ZIEGLER, M.P.H., FREDERICK H. WENTWORTH, M.D., WINSLOW J. BASHE JR., M.D.TRICHINOSIS: REPORT OF CASE MANIFESTING MYOCARDITIS, ENCEPHALITIS AND RADIAL NEURITIS; RESPONSE TO ACTH; REVIEW OF LITERATURE REGARDING THE ERYTHROCYTE SEDIMENTATION RATE*DAN C. ROEHM, M.D.TRICHINOSIS IN GREENLAND 1 February 1947Volume 26, Issue 2Page: 250-262KeywordsFeversIngestionMucous membranes ePublished: 1 December 2008 Issue Published: 1 February 1947 PDF downloadLoading ...
Oral non-dystrophic bullous eruption mainly limited to the gingivae: a mechano bullous response.
Authors: LOUIS FORMAN, FERGAL F. NALLY
Journal: British Journal of Dermatology (1977)

Fourteen patients with recurrent blistering entirely restricted to the mouth have been observed for up to 7 years. Their average age was 52 years, and there was a predilection for females (ratio 2-5:1). Patients presented with thick-roofed blisters and denuded, red, boggy areas of mucosa. The area of maximal involvement with the labial gingiva, and whilst the blisters would arise spontaneously, mechanical trauma was the obvious provocative factor in all patients. Gentle friction on normal looking mucosa would produce a bulla which became blood filled. Re-epithelialization usually occurred within 1-3 weeks, with no scarring. Biopsies showed subepithelial bullae, and direct immunofluorescence was positive in the basement membrane zone of 2 of the 5 cases examined. The most striking feature was the extreme fragility of the epithelial attachment to the underlying corium, as shown by a useful clinical test with a probe. In 10 patients, the condition gradually remitted and the probe test became difficult to perform. The term acquired oral non-dystrophic epidermolysis bullosa was considered for the diagnosis, although a forme fruste of cicatricial mucous membrane pemphigoid remained an alternative.
Zosteriform relapse of B-cell lymphoma
Authors: W.Y. Au, A.C.L. Chan, Y.L. Kwong
Journal: British Journal of Dermatology (2000)

Journal Article Zosteriform relapse of B‐cell lymphoma Get access W.Y. Au, W.Y. Au Department of Pathology, Queen Elizabeth Hospital, Search for other works by this author on: Oxford Academic Google Scholar A.C.L. Chan, A.C.L. Chan Department of Pathology, Queen Elizabeth Hospital, Search for other works by this author on: Oxford Academic Google Scholar Y.L. Kwong Y.L. Kwong Division of Hematology and Oncology, Hong Kong E‐mail: ylkwong@hkucc.hku.hk Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 142, Issue 1, 1 January 2000, Pages 180–182, https://doi.org/10.1046/j.1365-2133.2000.03267.x Published: 01 January 2000
Abstract 2494: A pilot proteomic analysis to identify biomarker proteins in human pancreatic cancer using reverse phase protein array
Authors: Yu-jing Huang, Nianxiang Zhang, Marsha Frazier, Chongjuan Wei
Journal: Cancer Research (2014)

Abstract Background: Pancreatic cancer is the fourth leading cause of cancer death in the U.S, and with an overall 5-year survival rate less than 4%. The high mortality rate of patients with pancreatic cancer is primarily due to the difficulty of early diagnosis and a lack of effective therapies. There is an urgent need to discover novel molecular targets for early diagnosis and new therapeutic approaches to improve the clinical outcome of this deadly disease. Reverse-phase protein assay (RPPA), a high throughput proteomic approach, provides us a platform to identify differentially expressed proteins and characterize posttranslational protein modifications involved in tumorigenesis. Methods: In the present study here, we carried out proteomic analysis of pancreatic cancer specimens with matched adjacent, normal-appearing tissue samples from 15 pancreatic cancer patients to evaluate the differentially expressed biomarker proteins. The antibody panel used for RPPA included 132 key proteins involved in various cancer-related pathways. The paired t test was used to determine the significant differences between matched pairs, and the false discovery rate-adjusted p values (q values) were calculated to take into account the effect of multiple comparisons. Result: Out of the panel of 132 proteins included in RPPA, we found 19 of them had statistically significant differences in expression between matched pairs (q &amp;lt;0.05). Among these 19 proteins, AKT, -catenin, GAB2, and PAI-1 were identified as differentially overexpressed in the pancreatic tumor (a fold change of T/N ≥ 1.5). In addition, overexpression of AKT, -catenin, and GAB2 in pancreatic cancer tissue identified in RPPA has been confirmed by western blot analysis. Further analysis identified several significantly associated canonical pathways and overrepresented network functions using the Ingenuity Pathway Analysis (IPA) tool. Conclusion: In conclusion, among the three proteins identified in RPPA and validated by western blot, overexpression of GAB2 has not been reported previously in pancreatic cancer. Considering the essential role of GAB2 in two major signaling pathways in cancer (the PI3-AKT and the ERK signaling pathways), identification of GAB2 in pancreatic cancer may provide additional insight into this cancer's pathogenesis. Citation Format: Yu-jing Huang, Nianxiang Zhang, Marsha Frazier, Chongjuan Wei. A pilot proteomic analysis to identify biomarker proteins in human pancreatic cancer using reverse phase protein array. [abstract]. In: Proceedings of the 105th Annual Meeting of the American Association for Cancer Research; 2014 Apr 5-9; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2014;74(19 Suppl):Abstract nr 2494. doi:10.1158/1538-7445.AM2014-2494
Abstract MP92: Changes in Ectopic Fat are Associated with Changes in Adipokines in Healthy, Overweight/Obese Young Adults
Authors: Thomas R Radomski, Lina Bai, Emma Barinas-Mitchell, Molly B Conroy
Journal: Circulation (2015)

Background: Excess ectopic fat has been associated with increased cardiometabolic risk, which may partially stem from changes in adipokines such as leptin and adiponectin. Prior studies have demonstrated that increased leptin and decreased adiponectin are associated with an increase in body mass index (BMI), but few have examined changes in adipokines related to changes in ectopic fat. We hypothesized that in healthy overweight and obese young adults, a decrease in ectopic fat will be associated with decreased levels of leptin and increased levels of adiponectin. Methods: We analyzed 244 subjects participating in the Slow Adverse Vascular Effects (SAVE) study, a randomized trial of a behavioral weight loss intervention in 349 overweight and obese (BMI 25-40 kg/m2) men and women ages 20-45 years. Subjects underwent a CT scan of their abdomen and left thigh to quantify their amount of visceral (VAT) and intramuscular (IMAT) adipose tissue at baseline and 12 months. Serum concentrations of leptin and adiponectin were also measured at baseline and 12 months. We generated variables for the change in VAT, IMAT, adiponectin and leptin by subtracting 12-month from baseline values. To evaluate the association between changes in serum adipokine (dependent variable) levels with changes in VAT and left thigh IMAT (independent variables), we performed a series of multiple linear regression analyses controlling for: 1) age, sex, race and 2) previous variables + change in BMI tertile. Results: The mean age at baseline was 38 ± 6 years; 181 (74.5%) subjects were female; and 198 (81.5%) were white. Mean VAT at baseline was 115.27 ± 53.58 cm2 with a mean decrease of 17.54 ± 36.71 cm2 at 12 months. Mean left thigh IMAT was 12.76 ± 4.87 cm2 at baseline with a mean decrease of 5.05 ± 3.20 cm2 at 12 months. Serum adiponectin was 11.90 ± 6.15 μg/mL at baseline, with a mean increase of 0.14 ± 3.79 μg/mL at 12 months. Serum leptin was 25.11 ± 13.38 μg/mL at baseline, with a mean decrease of 4.26 ± 10.71μg/mL at 12 months. After adjusting for age, sex, and race, a decrease in VAT was significantly associated with an increase in adiponectin (P=0.010) and decrease in leptin (P&lt;0.001); a decrease in IMAT was significantly associated with an increase in adiponectin (P=0.003), but was not significantly associated with a decrease in leptin (P=0.297). Except for the association between a decrease in IMAT and decrease in leptin (P=0.048), these relationships were no longer significant after adjusting for change in BMI tertile. Conclusion: A decrease in ectopic fat was associated with an increase in adiponectin and a decrease in leptin in young overweight/obese adults after adjusting for age, sex, and race. This underscores the metabolic activity of ectopic fat and supports the role of adiponectin and leptin as mediators of cardiometabolic risk.
Estimating the number of suicides among Vietnam veterans
Authors: D A Pollock, P Rhodes, C A Boyle, P Decoufle, D L McGee
Journal: American Journal of Psychiatry (1990)

Unconfirmed reports that 50,000 or more Vietnam veterans have committed suicide give the impression that these veterans are at exceedingly high risk of suicide compared with other veterans and nonveterans of the same age. On the basis of projections from two population-based mortality studies, the authors estimate that fewer than 9,000 suicides occurred among all Vietnam veterans from the time of discharge through the early 1980s. The sixfold or greater relative risk of suicide implied by the unsubstantiated suicide death tolls is also demonstrated to be incompatible with the findings of epidemiologic studies of mortality risk among Vietnam veterans.
Correlates of self-reported and objectively determined exposure to Agent Orange
Authors: G P Korgeski, G R Leon
Journal: American Journal of Psychiatry (1983)

The authors examined the relationship between 100 Viet Nam veterans' self-reported and objectively determined exposure to the herbicide Agent Orange and the relationship between self- or objective ratings and self-reported psychological and medical problems. Veterans who believed they had been exposed reported more psychological and medical problems than the other veterans but did not differ on "success at living" indices; the medical problems many reported suggested psychosomatic etiologies. Grouped according to objective ratings of herbicide exposure, the veterans did not show such differences in psychological or medical problems. No differences on neuropsychological testing appeared, no matter how the subjects were grouped.
Emerging Infectious Diseases—Reply
Authors: Anthony S. Fauci
Journal: JAMA (2005)

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