EXPERIENCES WITH TYROTHRICIN IN RHINOLOGY, SURGERY AND DERMATOLOGY
Authors: Joseph L. Goldman, S. A. Roddenberry, M. P. Rizutto, Herbert E. Fitch, Morris Waisman
Journal: Annals of Internal Medicine (1947)

Article1 July 1947EXPERIENCES WITH TYROTHRICIN IN RHINOLOGY, SURGERY AND DERMATOLOGYJOSEPH L. GOLDMAN, S. A. RODDENBERRY, M. P. RIZUTTO, HERBERT E. FITCH JR., MORRIS WAISMANJOSEPH L. GOLDMANSearch for more papers by this author, S. A. RODDENBERRYSearch for more papers by this author, M. P. RIZUTTOSearch for more papers by this author, HERBERT E. FITCH JR.Search for more papers by this author, MORRIS WAISMANSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-27-1-103 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptIn the enthusiasm with which the medical profession has accepted and used penicillin as a chemotherapeutic agent, another antibiotic substance of considerable antibacterial activity has not received the full consideration it deserves. Although tyrothricin does not possess the broad application of penicillin because it cannot be administered systemically, this drug has a definite place in the treatment of surface infections. One of the great problems which lies ahead for the medical profession will be the accurate appraisal of the various chemotherapeutic and antibacterial agents available for different infections. In the treatment of mucous membrane and skin infections and surface wounds,...Bibliography1. SERGIEVE PG: Clinical use of gramicidin S, Lancet, 1944, ii, 717. CrossrefGoogle Scholar2. DUBOS RJ: Bacteriocidal effect of an extract of a soil bacillus on gram positive cocci, Proc. Soc. Exper. Biol. and Med., 1939, xl, 311-312. DUBOS, R. J., and HOTCHKISS, R. D.: The production of bacteriocidal substances by aerobic sporulating bacilli, Jr. Exper. Med., 1941, lxxiii, 629-640. DUBOS, R. J., and HOTCHKISS, R. D.: Origin, nature and properties of gramicidin and tyrocidine, Trans. and Stud. Coll. Phys. of Phila., 1942, x, 11-18. CrossrefGoogle Scholar3. LITTLEDUBOSHOTCHKISS RBRJRD: Gramicidin, novoxil and acriflavine for the treatment of the chronic form of streptococcic mastitis, Jr. Am. Vet. Assoc., 1941, xcviii, 189-199. LITTLE, R. B., DUBOS, R. J., HOTCHKISS, R. D., BEAN, C. W., and MILLER, W. T.: The use of gramicidin and other agents for the elimination of the chronic form of bovine mastitis, Jr. Vet. Res., 1941, xi, 305-312. SCHALM, W. W.: Treatment of bovine mastitis, Jr. Am. Vet. Med. Assoc., 1941, xcix, 196. Google Scholar4. CROWEFISHERWARDFOLEY SJAMATMK: Penicillin and tyrothricin in otolaryngology, Ann. Otol., Rhinol. and Laryng., 1943, lii, 541-572. Google Scholar5. GOLDMAN JL: Bacteriology of nose, sinuses and nasopharynx (Proceedings of Seminars on Recent Advances in Bacteriology and Immunology with Clinical Considerations, Gregory Shwartzman, M.D., Chairman), Jr. Mt. Sinai Hosp., 1943, ix, 921-927. Google Scholar6. GOLDMAN JL: To be published. Google Scholar7. JACOBSONDICK LOGF: Normal and abnormal flora of the nose, Jr. Am. Med. Assoc., 1941, cxvii, 2222-2225. CrossrefGoogle Scholar8. EBERT E: Local treatment of acute rhinitis with sulfathiazole, Arch. Otolaryng., 1943, xxxviii, 324-327. CrossrefGoogle Scholar9. SCHOENBACHENDERSMUELLER EBJFJH: The apparent effect of tyrothricin on Streptococcus hemolyticus in the rhinopharynx of carriers, Science, 1941, xciv, 217-218. CrossrefGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: *Received for publication July 13, 1946. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byDrilitol in External Ocular Diseases*The role of antibiotics in pediatrics 1 July 1947Volume 27, Issue 1Page: 103-113KeywordsAntibioticsChemotherapeutic agentsDermatologyDrugsMucous membranesPenicillinRhinologySkin infectionsSurgery ePublished: 1 December 2008 Issue Published: 1 July 1947 PDF downloadLoading ...