HEREDITY AND DISEASE
Authors: A G KNUDSON
Journal: Annals of Internal Medicine (1961)

Editorials1 February 1961HEREDITY AND DISEASEALFRED G. KNUDSON JR., M.D., PH.D.ALFRED G. KNUDSON JR., M.D., PH.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-54-2-345 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptAs man conquers disease caused directly by environmental factors (physical, chemical, and biologic), he turns his attention to diseases which are dependent largely or in part upon individual constitution, or genetic endowment. Of course, disease per se is not inherited, but the genes which comprise one's genetic endowment, or genotype, are inherited. Disease is a function of the somatic state, or phenotype, of an individual in a particular environment. The phenotype, in turn, is determined to a large extent by genotype. 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CrossrefMedlineGoogle Scholar34 Beutler E: The effect of in vivo modification of sickle hemoglobin on a patient with sickle-cell disease. Clin. Res. 8: 101, 1960. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: *From the Department of Pediatrics, City of Hope Medical Center, Duarte, California.†Although it is the gene effect which is dominant or recessive, it is common practice to refer to the allelic genes producing these effects as dominant or recessive genes. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 February 1961Volume 54, Issue 2Page: 345-354KeywordsBiologicsGenetic diseasesHeredityPediatricsPhenotypes ePublished: 1 December 2008 Issue Published: 1 February 1961 PDF downloadLoading ...