STREPTOMYCIN IN THE TREATMENT OF TUBERCULOSIS
Authors: J B AMBERSON, W H STEARNS
Journal: Annals of Internal Medicine (1948)

Article1 August 1948STREPTOMYCIN IN THE TREATMENT OF TUBERCULOSISJ. BURNS AMBERSON, F.A.C.P., WILLIAM H. STEARNSJ. BURNS AMBERSON, F.A.C.P.Search for more papers by this author, WILLIAM H. STEARNSSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-29-2-221 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe effects of streptomycin administered to tuberculous patients have been shown to be strikingly beneficial in some phases of the disease, equivocal in some, and quite insignificant in others. Toxic damage by the antibiotic has been a frequent occurrence but this can be minimized by limiting the dose and the length of treatment. A more serious disadvantage, insurmountable thus far, is the development of bacterial resistance to streptomycin which often nullifies its further therapeutic action. While its potency against tuberculosis is unprecedented by any other drug, there are already some manifest limitations of its effectiveness. It has not altered the...Bibliography1. SCHATZBUGIEWAKSMAN AESA: Streptomycin, a substance exhibiting antibiotic activity against gram-positive and gram-negative bacteria, Proc. Soc. Exper. Biol. and Med., 1944, lv, 66-69. CrossrefGoogle Scholar2. FELDMANHINSHAW WHHC: Effects of streptomycin on experimental tuberculosis in guinea pigs: A preliminary report, Proc. Staff Meet., Mayo Clinic, 1944, xix, 593-599. HINSHAW H. C. FELDMAN W. H.: Streptomycin in treatment of clinical tuberculosis: A preliminary report, ibid., 1945, xx, 313-318. Google Scholar3. MCDERMOTTMUSCHENHEIMHADLEYBUNNGORMAN WCSJPARV: Streptomycin in the treatment of tuberculosis in humans. I. Meningitis and generalized hematogenous tuberculosis, Ann. Int. Med., 1947, xxvii, 769-822. MUSCHENHEIM, C., MCDERMOTT, W., HADLEY S. J., HULL-SMITH, H., and TRACY, A., ibid., 989-1027. LinkGoogle Scholar4. STEENKEN W: Minutes of the fourth streptomycin conference, Veterans Administration, Oct. 9-12, 1947, St. Louis, p. 52. Google Scholar5. YOUMANSKARLSON GPAG: Streptomycin sensitivity of tubercle bacilli, Am. Rev. Tuberc., 1947, lv, 529-535. WILLISTON E. H., and YOUMANS, G. P.: Streptomycin resistant strains of tubercle bacilli, ibid., 536-539. Google Scholar6. FARRINGTONHULL-SMITHBUNNMCDERMOTT RFHPAW: Streptomycin toxicity, Jr. Am. Med. Assoc., 1947, cxxxiv, 1-29. Google Scholar7. LINCOLNKIRMSEDEVITO EMTWE: Tuberculous meningitis in children. A preliminary report of its treatment with streptomycin and "promizole," Jr. Am. Med. Assoc., 1948, cxxxvi, 593-597. CrossrefGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: New York, N. Y.*Presented at the San Francisco meeting of the American College of Physicians, April 22, 1948.From the Department of Medicine, Columbia University, College of Physicians and Surgeons, and the Chest Service of Bellevue Hospital. Nextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByTHE EFFECT OF STREPTOMYCIN ON TUBERCULOUS MENINGITIS*HENRY D. BRAINERD, M.D., HENRY R. EAGLE, M.D.Tuberculosis in Infants and Children Treated with StreptomycinThe Value of Streptomycin in the Treatment of Tuberculosis 1 August 1948Volume 29, Issue 2Page: 221-228KeywordsAntibioticsDrugsHospital medicineStreptomycinSurgeonsThorax Issue Published: 1 August 1948 CopyrightCopyright, 1948, by The American College of PhysiciansPDF DownloadLoading ...