tbuckley/cabot-search huggingface dataset:
Unraveling the Influence of Gut Microbes on the Mind
Authors: M. J. Friedrich
Journal: JAMA (2015)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Control of SHIV-89.6P-infection of cynomolgus monkeys by HIV-1 Tat protein vaccine
Authors: Aurelio Cafaro, Antonella Caputo, Claudio Fracasso, Maria T. Maggiorella, Delia Goletti, Silvia Baroncelli, Monica Pace, Leonardo Sernicola, Martin L. Koanga-Mogtomo, Monica Betti, Alessandra Borsetti, Roberto Belli, Lennart Åkerblom, Franco Corrias, Stefano Buttò, Jonathan Heeney, Paola Verani, Fausto Titti, Barbara Ensoli
Journal: Nature Medicine (1999)
Pneumothorax and Mediastinal and Subcutaneous Emphysema in Children with Bronchial Asthma
Authors: J R JORGENSEN, C J FALLIERS, S C BUKANTZ
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Long-Continued Function of Normal Blood-Forming Tissue Transplanted Into Genetically Anemic Hosts&lt;xref ref-type="fn" rid="FN1"&gt;2&lt;/xref&gt;
Authors: Elizabeth S. Russell, Seldon E. Bernstein, Fay A. Lawson, Lois Jean Smith
Journal: JNCI Journal of the National Cancer Institute (1959)

Evidence has been presented for the very long persistence and genotypically autonomous functioning of isologous normal ww blood-forming tissue in X-irradiated genetically anemic WWυ hosts. For more than 500 days the blood pictures of anemic mice implanted with isologous ww fetal liver cells corresponded closely with those of untreated control ww mice of comparable age and genetic background rather than with those of untreated WWυ mice. Even after this period, mean cell volumes and erythrocyte counts indicated that implanted ww cells were functioning. Importance of the W-genotype of implanted cells was demonstrated by the lack of a beneficial result from injections of isologous WW or WWυ fetal cells in irradiated anemic hosts. The ww-implanted WWυ anemics tended to live longer than both irradiated and nonirradiated control WWυ anemics; this suggested that the genotype of functioning hematopoietic tissue may have an important influence upon longevity.
Failure to Induce Sarcoma in Rats with Wheat Germ Oil Preparations
Authors: Austin M. Brues, Beula B. Marble, Byron Riegel
Journal: Cancer Research (1941)

The production of neoplasms in albino rats by the feeding of crude wheat germ oil, made by ether extraction, has been reported by Rowntree and colleagues (6, 1I, i2, I3). Oils made by other methods than ether extraction did not give rise to tumors. The effect was not strain-specific, since abdominal sarcomas were produced in rats of the Wistar, Buffalo, and Yale strains. These rats were maintained on a special diet throughout the experiment.
Hip protectors
Authors: I. D Cameron
Journal: BMJ (2002)

<h3>Introduction</h3> Ehlers-Danlos syndrome is a group of 13 hereditary connective tissue disorders due to defects in collagen formation, folding or interaction. Kyphoscoliotic EDS (kEDS) is characterized by severe congenital hypotonia, early-onset progressive kyphoscoliosis, joint hypermobility, hyperelastic skin and myopathy. The majority of patients have biallelic mutations in the PLOD1 gene, and others in the FKBP14 gene. The clinical phenotype is indistinguishable, except for hearing impairment, occurring in FKBP14-kEDS only. FKBP14-kEDS (OMIM 614557) is an ultra-rare disease with less than 30 patients described. We present our patient in order to raise awareness of connective tissue disorders in the differential diagnosis of floppy infant syndrome. <h3>Case Presentation</h3> The patient was born after a normal pregnancy and delivery. Family history is unremarkable. Parents are unrelated. Joint hypermobility and weak cry were present at birth. Hearing screening revealed left-sided hearing impairment, confirmed by audiometry. Brain, heart, abdominal ultrasound and ophthalmic examination were normal. After the discharge newborn thrived well but had a severe motor delay. He was referred to our institution at the age of 3 months with severe hypotonia, hypermobile joints, extremities in a frog-like position, redundant skin, no head control, bell-shaped thorax with pectus excavatum, mild thoracolumbar kyphosis, spina bifida occulta, umbilical hernia, undescended testicles, and talipes calcaneovalgus. Social contact was normal. Metabolic workup and gene analyses for spinal muscular atrophy, myotonic dystrophy type 1 and Prader-Willi syndrome gave normal results. Brain MRI was normal. Electromyoneurography showed myopathy. Muscle biopsy revealed abnormal mitochondria and decreased activities of all respiratory chain complexes. Mitochondriopathy was suspected and „mitochondrial-cocktail’ therapy was started. At two years of age, the patient was severely hypotonic, with myopathic face, hyperelastic joints and skin, easy bruising, thoracolumbar kyphoscoliosis, and normal mental development. He started to walk at the age of 3.5 years. At the age of 5 years, he developed severe osteoporosis and kyphoscoliosis progressed. Whole exome sequencing (WES) revealed homozygous mutation c.362dupC (p.Glu122fs) in the FKBP14 gene. <h3>Conclusion</h3> Collagen myopathies should be in the differential diagnosis of floppy infant syndrome. Skin hyperextensibility and improvement of motor function with age may help to distinguish kEDS from collagen VI-related myopathies. Diagnosis can be confirmed by single gene or multigene panel testing. In a diagnostic dilemma, as in this case, in which some findings pointed to the diagnosis of mitochondrial disease, WES could be the best diagnostic approach. Accurate diagnosis ensures optimal patient management, complications insight, and appropriate genetic counselling.
Abstract 15353: The HEART Pathway Randomized Trial: Identifying Emergency Department Patients with Acute Chest Pain for Early Discharge
Authors: Simon A Mahler, Robert F Riley, Brian C Hiestand, Gregory Russell, James W Hoekstra, Cedric W Lefebvre, Bret A Nicks, David M Cline, Kim L Askew, Stephanie B Elliott, David M Herrington, Gregory L Burke, Chadwick D Miller
Journal: Circulation (2014)

Introduction: The HEART Pathway is a decision aid designed to identify emergency department (ED) patients with acute chest pain for early discharge. This trial compares the efficacy of the HEART Pathway versus usual care (UC) for ED chest pain risk stratification. Hypothesis: The HEART Pathway will increase the early discharge rate of ED patients with chest pain by ≤20% compared to UC without missing major adverse cardiac events (MACE) at 30 days. Methods: Adult ED patients with chest pain concerning for acute coronary syndrome without ST-elevation on initial electrocardiogram were randomized to the HEART pathway or UC (based on ACC/AHA guidelines). In the HEART Pathway arm, ED providers used the HEART Score, a validated risk stratification tool, and troponins at 0 and 3 hours to identify patients for early discharge. Outcomes included rate of early discharge (ED discharge without objective testing), rate of objective cardiac testing (stress testing or angiography), index hospital length of stay (LOS), an...
Breakthrough invasive fungal disease in patients receiving posaconazole primary prophylaxis: a 4-year study
Authors: N. Lerolle, E. Raffoux, G. Socie, S. Touratier, H. Sauvageon, R. Porcher, S. Bretagne, A. Bergeron, E. Azoulay, J.-M. Molina, M. Lafaurie
Journal: Clinical Microbiology and Infection (2014)
In vivo gene therapy of metachromatic leukodystrophy by lentiviral vectors: correction of neuropathology and protection against learning impairments in affected mice
Authors: Antonella Consiglio, Angelo Quattrini, Sabata Martino, Jean Charles Bensadoun, Diego Dolcetta, Alessandra Trojani, Giuliana Benaglia, Sergio Marchesini, Vincenzo Cestari, Alberto Oliverio, Claudio Bordignon, Luigi Naldini
Journal: Nature Medicine (2001)
PTPRC (CD45) is not associated with the development of multiple sclerosis in U.S. patients
Authors: Lisa F. Barcellos, Stacy Caillier, Leonard Dragone, Melissa Elder, Eric Vittinghoff, Patricia Bucher, Robin R. Lincoln, Margaret Pericak-Vance, Jonathan L. Haines, Arthur Weiss, Stephen L. Hauser, Jorge R. Oksenberg
Journal: Nature Genetics (2001)
<scp>H</scp>odgkin transformation of chronic lymphocytic leukemia: <scp>I</scp>ncidence, outcomes, and comparison to <i>de novo</i><scp>H</scp>odgkin lymphoma
Authors: Sameer A. Parikh, Thomas M. Habermann, Kari G. Chaffee, Timothy G. Call, Wei Ding, Jose F. Leis, William R. Macon, Susan M. Schwager, Kay M. Ristow, Luis F. Porrata, Neil E. Kay, Susan L. Slager, Tait D. Shanafelt
Journal: American Journal of Hematology (2015)

Although transformation to Hodgkin lymphoma (HL) is a recognized complication in patients with chronic lymphocytic leukemia (CLL), its incidence, clinical characteristics and outcomes are not well defined. We used the Mayo Clinic CLL and Lymphoma Databases to identify CLL patients who developed biopsy-proven HL (CLL/HL) on follow-up, as well as cases of de novo HL (i.e., without prior CLL). Among 3887 CLL patients seen at Mayo Clinic from January 1995 through August 2011, 26 (0.7%) developed HL. In a nested cohort of 2,465 newly diagnosed CLL patients followed prospectively, the incidence of HL was 0.05%/year (10 year risk = 0.5%). The median overall survival (OS) from date of HL diagnosis in patients with CLL/HL was 3.9 years compared to not reached for de novo HL patients (n = 709) seen during the same time interval (P < 0.001). The shorter OS of CLL/HL patients persisted after adjusting for differences in age and Ann Arbor stage of disease. The International Prognostic score (IPS) developed for de novo HL stratified prognosis among CLL/HL patients with median survival of not reached, 6.2, 2.4, and 0.3 years (P = 0.006) for those with IPS scores of ≤2, 3, 4, and ≥5, respectively. In summary, approximately 1 of every 200 CLL patients will develop HL within 10 years. Survival after HL diagnosis in patients with CLL is shorter than de novo HL patients. The IPS for de novo HL may be useful for stratifying survival in CLL/HL patients.
Abstract 2020: Spheroid culture of primary colorectal cancer cells from liver metastases as an <i>in vitro</i> model of patient tumors
Authors: Maria Jeppesen, Grith Hagel, Ben Vainer, Henrik Harling, Ole Thastrup, Lars Nannestad Jorgensen, Jacob Thastrup
Journal: Cancer Research (2014)

Abstract More than 65 % of patients with colorectal cancer require chemotherapeutic treatment during the course of their disease. However, colorectal tumors demonstrate pronounced heterogeneity, leading to significant individual variation in sensitivity to standard chemotherapeutic drugs. Tools for assessing chemosensitivity and tailoring therapeutic regimens to the individual patient are therefore urgently needed. A promising approach is to isolate viable cancer cells from patient tissue and to test the chemosensitivity of the individual tumor in vitro. The aim of the current study was to establish primary colorectal cancer cell cultures from patient liver metastases and investigate if the cultured cells retained important characteristics of the original tumor. Small cell clusters were isolated from metastatic tissue and allowed to form cell spheroids in suspension culture. The cell composition of patient spheroids was characterized by immunostaining with cell type specific antibodies. Cancer stem cells were identified by staining for the markers CD44, CD166 and Lgr5. Spheroid size was monitored over time and growth curves established for each patient. The distribution of proliferating and apoptotic cells in the spheroids was assessed by staining for specific markers. Overall, the 3-D culture system was verified as a tumor model by comparing the results obtained for the spheroids to paraffin-embedded sections of the original tumors. Successful spheroid culture was obtained from more than 80 % of tissue samples. Immunostaining confirmed that the primary cultures were composed of epithelial cells with minimal contamination by other cell types. Cell morphology and expression of intestinal markers confirmed their malignant nature and colorectal origin. The dominating cell populations of the original tumor could generally be identified in the derived spheroids as well. The spheroids demonstrated significant growth in vitro with no decrease in proliferation or increase in apoptosis during short-term culture. In summary, spheroid cultures of colorectal cancer cells can be established from liver metastases of individual patients with a high success rate and the spheroids retain important cellular characteristics of the original tumor. Spheroid culture therefore represents a promising technique for establishing primary cultures for chemotherapeutic screening of the individual patient. Citation Format: Maria Jeppesen, Grith Hagel, Ben Vainer, Henrik Harling, Ole Thastrup, Lars Nannestad Jorgensen, Jacob Thastrup. Spheroid culture of primary colorectal cancer cells from liver metastases as an in vitro model of patient tumors. [abstract]. In: Proceedings of the 105th Annual Meeting of the American Association for Cancer Research; 2014 Apr 5-9; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2014;74(19 Suppl):Abstract nr 2020. doi:10.1158/1538-7445.AM2014-2020
Abstract P168: Early Markers of Rescuer's Fatigue
Authors: Charles Pozner, Adam Almozlino, Stephen Poole, De'ann McNamara, David Barash
Journal: Circulation (2009)

Purpose: Suboptimal CPR quality is usually attributed to the development of fatigue. Identifying early markers of rescuer’s fatigue may improve CPR quality. We therefore, assessed rescuer’s heart r...
THE DIAGNOSIS AND MEDICAL TREATMENT OF ANGINA PECTORIS
Authors: Paul D. White
Journal: Annals of Internal Medicine (1933)

Article1 August 1933THE DIAGNOSIS AND MEDICAL TREATMENT OF ANGINA PECTORISPAUL D. WHITE, M.D., F.A.C.P.PAUL D. WHITE, M.D., F.A.C.P.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-7-2-218 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptAngina pectoris is one of the most important and interesting conditions that we meet in the practice of medicine today. It has become increasingly so during our own generation and at present is a great and pressing challenge to us all. Our much vaunted civilization of but a few years ago has been receiving many rude shocks, and to these we may add the seemingly justified accusation that it has been responsible for much of the apparent increase in angina pectoris in our day. Certainly such apparent increase cannot be ascribed wholly to better diagnosis since our forebears for over... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: PAUL D. WHITE, M.D., F.A.C.P.Affiliations: Boston, Massachusetts*Presented before the American College of Physicians, Montreal, Canada, February 10, 1933. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byÜber die Entstehung des Herzinfarkts 1 August 1933Volume 7, Issue 2Page: 218-228KeywordsAnginaShock ePublished: 1 December 2008 Issue Published: 1 August 1933 PDF downloadLoading ...
Abstract 26: DASH-Style Eating Pattern in Early Adolescence Reduces Cardiometabolic Risk Clustering
Authors: Lynn L Moore, M. Loring Bradlee, Martha R Singer, Stephen R Daniels
Journal: Circulation (2015)

Cardiometabolic risk (CMR) factor clustering has its roots in childhood and the presence of multiple cardiovascular risk factors in younger populations has been linked with early vascular dysfunction. A DASH-style eating pattern has been shown to reduce blood pressure and other selected cardiometabolic outcomes, primarily in adults, but its role in the development of CMR clustering during adolescence has not been studied. Data from the National Heart, Lung, and Blood Institute’s Growth and Health Study (NGHS) will be used to evaluate the relation between early-to-mid adolescent dietary intake and CMR clustering at the end of adolescence. The NGHS began in 1987-1988 with the enrollment of 2,379 adolescent girls (with approximately equal numbers of blacks and whites), ages 9-10 years. Diet was assessed using 3-day diet records during eight of 10 years of follow up. A total of 1,369 girls had complete data on diet, all potential confounding variables, and follow-up over 10 years for all CMR factors of interest. Risk factor clustering scores were created by summing individual CMR outcomes defined as follows: waist circumference ≥88 cm, systolic and/or diastolic blood pressure ≥90th percentile for age, sex and height, LDL ≥110 mg/dL, HDL &lt;50 mg/dL, serum TG ≥110mg/dl, and HOMA-IR ≥4. Multiple logistic regression analyses were used to estimate the impact of a DASH-style pattern on the relative risk (odds ratio) of CMR clustering at the end of adolescence, defined as having ≥ 2 or ≥ 3 of the above risk factors at 18-20 years of age. The proportion of white and black girls with CMR clustering was very similar. However, the types of risk factors differed by race with blacks being nearly twice as likely to have an increased waist size, elevated BP, or insulin resistance and white girls being much more likely to have abnormal lipid levels, particularly elevated triglyceride levels. By the end of adolescence, only 30.1% of girls had no abnormal CMR factors and 34.9% had a single risk factor; 16.6% of girls had two risk factors and 18.4% had between 3-6 prevalent risk factors. Higher intakes of fruit and non-starchy vegetables, dairy, and grains were independently associated with less CMR clustering. After adjusting for age, race, socio-economic status, height, physical activity, and television watching, girls with a DASH-style eating pattern during early-to-mid adolescence were nearly 50% less likely to have three or more CMR factors (O.R.=0.52; 95% CI: 0.30, 0.89) by late adolescence (at 18-20 years of age). These results suggest a DASH-style eating pattern during adolescence, characterized by higher intakes of fruit, non-starchy vegetables, and dairy, may lower risk for the development of subsequent cardiometabolic disorders.
Randomized Phase II Study of Fludarabine + Cytosine Arabinoside + Idarubicin ± All-Trans Retinoic Acid ± Granulocyte Colony-Stimulating Factor in Poor Prognosis Newly Diagnosed Acute Myeloid Leukemia and Myelodysplastic Syndrome
Authors: Elihu H. Estey, Peter F. Thall, Sherry Pierce, Jorge Cortes, Miloslav Beran, Hagop Kantarjian, Michael J. Keating, Michael Andreeff, Emil Freireich
Journal: Blood (1999)
656. Potential Regulatory Function of Dendritic Cells Overexpression Indoleamine 2,3-Dioxygenase
Authors: Naoko Funeshima, Masayuki Fujino, Yusuke Kitazawa, Torayuki Okuyama, Xiao-kang Li
Journal: Molecular Therapy (2004)

Indoleamine 2,3-dioxygenase (IDO) is an enzyme, involved in the catabolism of tryptophan and has been show to prevent rejection of the fetus during pregnancy, probably by inhibiting alloreactive T cells. In the present study, we investigated whether DCs that are transfected with IDO cDNA in inhibition of T cell proliferation after antigen-specific interaction. XS106 DCs, derived from A/J mice (H-2k) were transduced IDO with a gene delivery system using a recombinant adenoviral vector. Western blot and immune staining revealed IDO expression in XS106 DCs trasduced IDO (XS106-IDO DCs) and its catabolic effect was confirmed by increase the kynurenine concentration. Fluorescence activated cell sorter revealed that XS106-IDO DCs were no changeable for Ia, CD80 and CD86 expression. After co-cultured XS106-IDO DCs with C57BL/6 allogeneic splenic T cell, the proliferation of the T cell was inhibited significantly. The co-cultured T cells with XS106-IDO DCs were showed cell cycle arrest. Furthermore, injection of XS160-IDO DCs to the footpad of the C57BL/6 (H-2b) mice demonstrated that reduction of T cell response against allo-antigen. These results suggested that over expression of the IDO in the DC was effective to inhibit T cell proliferation, and may expand a new immunomodulatory strategy to prevent the allo-rejection of the organ transplantation.
787. Lentivirus Mediated Dystrophin Expression in mdx Muscles
Authors: En Kimura, Sheng Li, Brent Fall, Miki Haraguchi, Leonard Meuse, Jeffery S. Chamberlain
Journal: Molecular Therapy (2005)

In dystrophic muscles of the mdx mouse, a model for Duchenne muscular dystrophy, activated-satellite cells (myoblasts) proliferate in the muscle micro- environment during regeneration and degeneration processes. Most of these cells terminally differentiate and form myofibers, while small numbers are stored adjacent to myofibers as mitotically quiescent satellite cells for future muscle regeneration.