GASTROINTESTINAL COMPLICATIONS OF COLCHICINE THERAPY IN GOUT
Authors: E SHANBROM, L RAPOPORT
Journal: Annals of Internal Medicine (1958)

Case Reports1 March 1958GASTROINTESTINAL COMPLICATIONS OF COLCHICINE THERAPY IN GOUTEDWARD SHANBROM, M.D., LEONARD RAPOPORT, M.D.EDWARD SHANBROM, M.D.Search for more papers by this author, LEONARD RAPOPORT, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-48-3-655 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptColchicine has a long and venerable history in the treatment of gouty arthritis, and even now is generally considered the drug of choice for this disease. Since it has been used for gouty arthritis since the fifteenth century, it is not surprising that its pharmacology has been intensively studied and its toxic manifestations have been well described. It is the purpose of this paper to review the gastrointestinal complications associated with colchicine therapy, and to present two cases observed at surgery in which certain unusual lesions were observed which may have been produced by colchicine.Poisoning due to colchicine produces...Bibliography1. Sollman T: A manual of pharmacology and its applications to therapeutics and toxicology, 7th Ed., 1948, W. B. Saunders Co., Philadelphia. Google Scholar2. Grollman A: Pharmacology and therapeutics, 1951, Lea and Febiger, Philadelphia. Google Scholar3. GoodmanGilman LAC: The pharmacological basis of therapeutics, 1941, The Macmillan Co., New York. Google Scholar4. OsolFarrar AGE, Editors: The dispensatory of U. S. of America, 1950, Lippincott, Philadelphia. Google Scholar5. DavisBartfeld JFH: The effect of intravenous colchicine on acute gout, Am. J. Med. 16: 2, 1954. CrossrefGoogle Scholar6. Personal communication to E. S. Google Scholar7. BoylandBoyland EME: Studies in tissue metabolism. The action of colchicine and B. typhosus extract, Biochem. J. 31: 454, 1937. CrossrefMedlineGoogle Scholar8. MusottoDiquattro GC: Sull iperplasia delle cellule istiocitarie in sequito a dosi riqetute di colchicina, Pathologica 39: 204, 1947. MedlineGoogle Scholar9. Lits SJ: Recherches sur les réactions et lésions cellulaires provoquées par la colchicine, Arch. internat. de med. exper. 11: 811, 1936. Google Scholar10. LitsKirschbaumStrong SJALC: Action of colchicine on a transplanted malignant lymphoid neoplasm in mice of the C3H strain, Am. J. Cancer 34: 196, 1938. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: *Received for publication June 25, 1956.From the Medical and Surgical Services of the Veterans Administration Hospital, West Haven, Connecticut, and Yale University School of Medicine.†Formerly U. S. Public Health Research Fellow, Department of Internal Medicine, Yale University School of Medicine.Requests for reprints should be addressed to Edward Shanbrom, M.D., Lymphoma-Leukemia Service, City of Hope Medical Center, Duarte, California. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byGastrointestinal effects of long-term colchicine therapy in patients with recurrent polyserositis (familial Mediterranean fever)Colchicine suppression of corneal healing after strabismus surgery.Drug-induced MalabsorptionBone marrow depression associated with acute colchicine toxicity in the presence of hepatic dysfunctionMalignant Gout with Tophaceous Small Intestine and Megaloblastic AnaemiaEfficacy of Colchicine Prophylaxis in Gout Prevention of Recurrent Gouty Arthritis Over a Mean Period of Five Years in 208 Gouty SubjectsTS'AI FAN YÜ, M.D., ALEXANDER B. GUTMAN, M.D., F.A.C.P.RHEUMATISM AND ARTHRITIS: REVIEW OF AMERICAN AND ENGLISH LITERATURE OF RECENT YEARS (THIRTEENTH RHEUMATISM REVIEW)*CHARLEY J. SMYTH, M.D., F.A.C.P., ROGER L. BLACK, M.D., FELIX E. DEMARTINI, M.D., IVAN F. DUFF, M.D., F.A.C.P., EPHRAIM P. ENGLEMAN, M.D., F.A.C.P., DONALD C. GRAHAM, M.D., F.R.C.P.(C), MAX M. MONTGOMERY, M.D., F.A.C.P., HOWARD F. POLLEY, M.D., F.A.C.P., EDWARD F. ROSENBERG, M.D., F.A.C.P., CARLOS F. SACASA, M.D., F.A.C.P., OTTO STEINBROCKER, M.D., HANS WAINE, M.D., GEORGE M. WILSON JR., M.D. 1 March 1958Volume 48, Issue 3Page: 655-660KeywordsArthritisColchicineHospital medicineIngestionLesionsPeptic ulcersPharmacologyPrevention, policy, and public healthSurgeryUlcers ePublished: 1 December 2008 Issue Published: 1 March 1958 PDF downloadLoading ...