EXTREME CARDIAC ENLARGEMENT
Authors: C C EPSTEIN
Journal: Annals of Internal Medicine (1958)

Case Reports1 June 1958EXTREME CARDIAC ENLARGEMENTCARL C. EPSTEIN, M.D., F.A.C.P.CARL C. EPSTEIN, M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-48-6-1387 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptA patient with rheumatic heart disease and acromegaly presented at postmortem examination an extremely large heart weighing 1,340 gm. The size of the organ was so striking as to remind an observer of hearts removed from steers in the abattoir. The case appears of sufficient interest to report in detail together with a review of the literature concerned particularly with massive cardiac hypertrophy. As Evans and White1have stated such case reports may assist by supplying information as to etiologic factors concerned with massive cardiac enlargement, in leading to a better understanding of the pathogenesis of cardiac failure in advanced...Bibliography1. EvansWhite LRPD: Massive hypertrophy of the heart with special reference to Bernheim's syndrome, Am. J. M. Sc. 216: 485, 1948. CrossrefMedlineGoogle Scholar2. Sedgwick W: A case of great hypertrophy of the heart, Lancet 2: 332, 1854. CrossrefGoogle Scholar3. GoldenBrams JSWA: Extreme cardiac enlargement, Am. Heart J. 13: 207, 1937. CrossrefGoogle Scholar4. Smith : Case of monstrous hypertrophy of the heart, New York J. Med. 5: 207, 1850. Google Scholar5. Cabot RC: Facts on the heart, 1926, W. B. Saunders Company, Philadelphia, pp. 429-436. Google Scholar6. RosenowSmith ECHL: Extreme cardiac hypertrophy. A report of forty-four cases in which the heart weighed 800 gm. or more, Minnesota Med. 22: 739, 1939. Google Scholar7. Smith HL: The relation of the weight of the heart to the weight of the body and the weight of the heart to age, Am. Heart J. 4: 79, 1928. CrossrefGoogle Scholar8. Bernheim : De l'asystolie veineuse dans l'hypertrophie du coeur gauche, Rev. de med. 30 785, 1910. Google Scholar9. BlandBalboniWhite EFGMPD: Enormous increase in heart volume with mitral stenosis. Report of a case, J. A. M. A. 96: 840, 1931. CrossrefGoogle Scholar10. Hochrein M: Untersuchungen am Venösen Teil des Kreislaufes, Arch. f. exper. Path. u. Pharmakol. 124: 343, 1927. CrossrefGoogle Scholar11. CourvilleMason CVR: The heart in acromegaly, Arch. Int. Med. 61: 704, 1938. CrossrefGoogle Scholar12. HejtmancikBradfieldHerrmann MRJYGR: Acromegaly and the heart: a clinical and pathologic study, Ann. Int. Med. 34: 1445, 1951. LinkGoogle Scholar13. Marie P: Sur deux cas d'acromégale; hypertrophie singulière non congénitale des extrémités inférieures et céphalique, Rev. de méd., Paris 6: 297, 1886. Google Scholar14. Huchard H: Anatomie pathologique, lésions et troubles cardio-vasculaires de l'acromégalie, J. d. praticiens 9: 249, 1895. Google Scholar15. Fournier JB: Acromégalie et troubles cardiovasculaires, Thesis, Paris, No. 3, 1896. Google Scholar16. PaviotBeutter JM: Acromégalie; splanchnomégalie; gros coeur; mort parasystolie, Lyon méd. 36: 1088, 1904. Google Scholar17. HumphreyDixon LWE: A case of acromegaly with hypertrophied heart; pressor substances in the urine, Brit. M. J. 2: 1047, 1910. Google Scholar18. Amsler C: Zur Lehre der Splanchnomegalie bei Akromegalie, Berl. klin. Wchnschr. 2: 1600, 1912. Google Scholar19. Bassoe P: Acromegaly, in Endocrinology and metabolism, 1922, D. Appleton and Co., New York, vol. 1, p. 805. Google Scholar20. Sternberg M: Acromegaly, translated by F. R. B. Atkinson, 1899, H. K. Lewis, London. Google Scholar21. CushingDavidoff HLM: The pathological findings in four autopsied cases of acromegaly, with discussion of their significance, Monograph 22, Rockefeller Institute for Medical Research, 1927. Google Scholar22. Krauss JE: Morphologic aspects and genesis of disorders of the adenohypophysis, Arch. Path. 40: 190, 1945. Google Scholar23. Selye H: Textbook of endocrinology, 1948, Université de Montreal, Montreal. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Oakland, California*Received for publication December 10, 1956.From the Department of Medicine, Veterans Administration Hospital, Oakland, California.Requests for reprints should be addressed to Carl C. Epstein, M.D., Veterans Administration Hospital, Thirteenth and Harrison Streets, Oakland 12, California. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byIdiopathic gardiomegaly with extreme cardiac enlargement 1 June 1958Volume 48, Issue 6Page: 1387-1401KeywordsAdenomasAutopsyCardiac hypertrophyCardiovascular therapyFibrosisHeartHeart failureHospital medicineHypertensionPathogenesis ePublished: 1 December 2008 Issue Published: 1 June 1958 PDF downloadLoading ...