RADIOACTIVE PHOSPHORUS IN THE TREATMENT OF CHRONIC LEUKEMIAS: LONG-TERM RESULTS OVER A PERIOD OF 15 YEARS
Authors: E H REINHARD, C L NEELY, D M SAMPLES
Journal: Annals of Internal Medicine (1959)

Article1 April 1959RADIOACTIVE PHOSPHORUS IN THE TREATMENT OF CHRONIC LEUKEMIAS: LONG-TERM RESULTS OVER A PERIOD OF 15 YEARSEDWARD H. REINHARD, M.D., F.A.C.P., CHARLES L. NEELY, M.D., DON M. SAMPLES, M.D.EDWARD H. REINHARD, M.D., F.A.C.P.Search for more papers by this author, CHARLES L. NEELY, M.D.Search for more papers by this author, DON M. SAMPLES, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-50-4-942 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptIn recent years most publications on the subject of treatment of the chronic leukemias have dealt with the results of therapy with new chemotherapeutic agents. Dimethanesulfonoxybutane (Myleran) is now considered by many hematologists to be the treatment of choice in chronic granulocytic leukemia, and chlorambucil (Leukeran) is being used more and more extensively in the therapy of chronic lymphocytic leukemia. There are few reported series of large numbers of patients with chronic leukemia treated with radioactive phosphorus and followed over a long period of time. Such a study should be of great value as a basis for comparison with the...Bibliography1. ShimkinLuciaOppermannMettier MBELKCSR: Lymphocytic leukemia: an analysis of frequency, distribution and mortality at the University of California Hospital, 1913-1947, Ann. Int. Med. 39: 1254, 1953. LinkGoogle Scholar2. MinotIsaacs GRR: Lymphatic leukemia: age incidence, duration and benefit derived from irradiation, Boston M. and S. J. 191: 1, 1924. CrossrefGoogle Scholar3. 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ReinhardMooreBierbaumMoore EHCVOSS: Radioactive phosphorus as a therapeutic agent, J. Lab. and Clin. Med. 31: 107, 1946. MedlineGoogle Scholar16. DoanWisemanWrightGeyerMeyersMyers CABKCSJHWJW: Radioactive phosphorus, P-32; 6-year clinical evaluation of internal radiation therapy, J. Lab. and Clin. Med. 32: 943, 1947. MedlineGoogle Scholar17. LawrenceDobsonLow-BeerBrown JHRLBVBR: Chronic myelocytic leukemia; study of 129 cases in which treatment was with radioactive phosphorus, J. A. M. A. 136: 672, 1948. CrossrefMedlineGoogle Scholar18. LawrenceLow-BeerCarpenter JHBVJW: Chronic lymphatic leukemia; study of 100 patients treated with radioactive phosphorus, J. A. M. A. 140: 585, 1949. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: *Received for publication August 26, 1958.Presented at the Thirty-ninth Annual Session of The American College of Physicians, Atlantic City, New Jersey, April 28, 1958.From the Department of Medicine, Washington University School of Medicine, and the Barnes Hospital, St. Louis, Missouri.†Fellow in Hematology, supported by the National Cancer Institute.‡National Cancer Institute Trainee in Medicine (Hematology).Requests for reprints should be addressed to Edward H. Reinhard, M.D., Wohl Memorial Hospital, 4960 Audubon Avenue, St. Louis 10, Missouri. 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CARBONE, M.D., J. H. TJIO, M.D., JACQUELINE WHANG, M.D., JEROME B. BLOCK, M.D., WILLIAM B. KREMER, M.D., EMIL FREI III, M.D.A Clinical and Pathological Study of Seventy Cases of MyelofibrosisJAMES A. PITCOCK, M.D., EDWARD H. REINHARD, M.D., F.A.C.P., BERTRAM W. JUSTUS, M.D., ROBERT S. MENDELSOHN, M.D.Langzeit-Chemotherapie chronisch-mycloischer Leuk�mien mit Myleran und C 69Management of Reticuloendothelial MalignanciesClinical manifestations of leukemiaThe clinical management of leukemiaLeukemia: Some Present-Day Problems 1 April 1959Volume 50, Issue 4Page: 942-958KeywordsBiostatisticsChemotherapeutic agentsChronic lymphocytic leukemiaHematology and oncologyHemoglobinHospital medicineLeukemiaPhosphorusStatistical data ePublished: 1 December 2008 Issue Published: 1 April 1959 PDF downloadLoading ...