STUDIES IN A CASE OF CHRONIC IDIOPATHIC JAUNDICE
Authors: E R BURKA
Journal: Annals of Internal Medicine (1960)

Case Reports1 February 1960STUDIES IN A CASE OF CHRONIC IDIOPATHIC JAUNDICEEDWARD R. BURKAEDWARD R. BURKASearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-52-2-453 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptINTRODUCTIONIt is now recognized that there are at least two distinct types of chronic nonhemolytic jaundice characterized by a benign prognosis and a familial tendency. In the first of these, described by Gilbert in 1902,1there is an elevated serum bilirubin of the indirect-reacting type, normal bromsulfalein excretion, negative cephalin flocculation and thymol turbidity tests, and normal liver morphology and oral cholecystography.2In the second type, described by Dubin and Johnson3and Sprinz and Nelson4in 1954, the serum bilirubin is both indirect- and direct-reacting. This latter condition, termed chronic idiopathic jaundice with unidentified pigment in the liver cells,5...Bibliography1. GilbertLerboullet AP: La cholemie simple familiale, Gaz. hebd. de méd. 49: 889, 1902. Google Scholar2. ComfortHoyne MWRM: Constitutional hepatic dysfunction: clinical study of 35 cases, Gastroenterology 3: 155, 1944. Google Scholar3. DubinJohnson INFB: Chronic idiopathic jaundice with unidentified pigment liver cells; a new clinico-pathologic entity with a report of 12 cases, Medicine 33: 155, 1954. CrossrefMedlineGoogle Scholar4. SprinzNelson HRS: Persistent nonhemolytic hyperbilirubinemia associated with lipochrome-like pigment in liver cells; report of four cases, Ann. Int. Med. 41: 952, 1954. LinkGoogle Scholar5. Dubin IM: Chronic idiopathic jaundice, Am. J. Med. 24: 268, 1958. CrossrefMedlineGoogle Scholar6. AriasLondon IMIM: Bilirubin glucuronide formation in vitro; demonstration of a defect in Gilbert's disease, Science 126: 563, 1957. CrossrefMedlineGoogle Scholar7. RudmanKendall DFE: Bile acid content of human serum. I. Serum bile acids in patients with hepatic disease, J. Clin. Investigation 36: 530, 1957. CrossrefMedlineGoogle Scholar8. Rudman D: Personal communication, 1958. Google Scholar9. SchachterManis DJ: Salicylate and salicyl conjugates: fluorimetric estimation, biosynthesis, and renal excretion in man, J. Clin. Investigation 37: 800-807, 1958. CrossrefMedlineGoogle Scholar10. CarboneGrodsky JVGM: Constitutional non-hemolytic hyperbilirubinemia in the rat: defect of bilirubin conjugation, Proc. Soc. Exper. Biol. and Med. 94: 461, 1957. CrossrefMedlineGoogle Scholar11. Schmid R: Congenital defects in bile metabolism, J. Clin. Investigation 36: 927, 1957. Google Scholar12. Schmid R: Direct-reacting bile, bilirubin glucuronide, in serum, bile, and urine, Science 124: 76, 1956. CrossrefMedlineGoogle Scholar13. Schmid R: The conjugation of bile with glucuronic acid, J. Lab. and Clin. Med. 48: 940, 1956. Google Scholar14. BollmanMann JLFC: The van den Bergh reaction in jaundice following complete removal of the liver, Arch. Surg. 24: 675, 1932. CrossrefGoogle Scholar15. GrodskyCarbone GMJV: The synthesis of bilirubin glucuronide by tissue homogenates, J. Biol. Chem. 226: 449, 1957. CrossrefMedlineGoogle Scholar16. BillingLathe BHGH: Bilirubin metabolism in jaundice, Am. J. Med. 24: 211, 1958. CrossrefGoogle Scholar17. Bollman JL: Proceedings of the Fifth Pan-American Congress of Gastroenterology, 1956. Google Scholar18. Schachter D: Unpublished method. Google Scholar19. Harzon V: Liver cell secretion under normal and pathological conditions studied by fluorescence microscopy in living rats, Acta physiol. Scandinav. Suppl. 101, 28: 268, 1952. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: *Received for publication October 3, 1958.From the Department of Medicine, College of Physicians and Surgeons, Columbia University, and The Presbyterian Hospital, New York, N. Y.Requests for reprints should be addressed to Captain Edward R. Burka, Headquarters Company, 504th Parachute Infantry Regiment, APO 185, New York, N. Y. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byStudies of Chronic Idiopathic Jaundice (Dubin-Johnson Syndrome)Studies of Chronic Idiopathic Jaundice (Dubin-Johnson Syndrome)CHRONIC IDIOPATHIC JAUNDICE WITH HEPATIC PIGMENTATION (DUBIN–JOHNSON SYNDROME) 1 February 1960Volume 52, Issue 2Page: 453-459KeywordsBileBilirubinExcretionFatigueHospital medicineLiverSurgeons ePublished: 1 December 2008 Issue Published: 1 February 1960 PDF downloadLoading ...