A CASE OF HAND-SCHÜLLER-CHRISTIAN SYNDROME TREATED WITH CORTISONE
Authors: W H BLAHD, M S LEVY, S H BASSETT
Journal: Annals of Internal Medicine (1951)

Case Reports1 October 1951A CASE OF HAND-SCHÜLLER-CHRISTIAN SYNDROME TREATED WITH CORTISONEWILLIAM H. BLAHD, M.D., MARVIN S. LEVY, M.D., SAMUEL H. BASSETT, M.D.WILLIAM H. BLAHD, M.D.Search for more papers by this author, MARVIN S. LEVY, M.D.Search for more papers by this author, SAMUEL H. BASSETT, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-35-4-927 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptIn 1893, under the title "General Tuberculosis," Hand1reported a case of a three year old child with a peculiar skin eruption, skull defects and yellow nodules in the liver and spleen. Kay2in 1905 described diabetes insipidus, skull defects and exophthalmos in a seven year old child, which he termed "acquired hydrocephalus with atrophic bone changes." Some years later Schüller3and Christian4described cases exhibiting essentially the same clinical manifestations, and attributed these changes to pituitary dysfunction. This original concept was altered, however, by the histologic studies of Rowland5in 1928, which indicated that the syndrome was related to...Bibliography1. Hand A: General tuberculosis, Proc. Path. Soc. Philadelphia 16: 282, 1891-1893. Google Scholar2. Kay TW: Acquired hydrocephalus with atrophic bone changes, exophthalmos and polyuria, Pennsylvania M. J. 9: 520, 1905-1906. Google Scholar3. Schüller A: Dysostosis hypophysaria, Brit. J. Radiol. 31: 156, 1926. Google Scholar4. Christian HA: Defects in membranous bones, exophthalmos and diabetes insipidus; an unusual syndrome of dyspituitarism, M. Clin. North America 3: 849, 1920. Google Scholar5. Rowland RS: Xanthomatosis and reticulo-endothelial system, Arch. Int. Med. 42: 611, 1928. CrossrefGoogle Scholar6. ThannhauserMagendantz SJH: The different clinical groups of xanthomatous diseases; a clinical physiological study of 22 cases, Ann. Int. Med. 11: 1662, 1938. LinkGoogle Scholar7. HolmTeilumChristensen JEGE: Eosinophilic granuloma of bone; Schüller-Christian disease, Acta med. Scandinav. 118: 292, 1944. CrossrefGoogle Scholar8. JaffeLichtenstein HLL: Eosinophilic granuloma of bone; a condition affecting one, several or many bones, but apparently limited to the skeleton, and representing the mildest clinical expression of peculiar inflammatory histiocytosis also underlying Letterer-Siwe disease and Schüller-Christian disease, Arch. Path. 37: 99, 1944. Google Scholar9. Farber S: The nature of "solitary or eosinophilic granuloma" of bone, Am. J. Path. 18: 625, 1941. Google Scholar10. Thannhauser SJ: Lipidoses, 1949, Oxford University Press, New York. Google Scholar11. KingsleyReinhold GRJG: The determination of true glucose in blood by reduction of ferricyanide, J. Lab. and Clin. Med. 34: 713, 1949. MedlineGoogle Scholar12. SchneirersonSchneider SJL: Lipoid granulomatosis (xanthomatosis) with marked pulmonary fibrosis and cor pulmonale, Ann. Int. Med. 30: 842, 1949. LinkGoogle Scholar13. Lichtenstein L: Personal communication. Google Scholar14. Freiman DG: Medical progress: sarcoidosis, New England J. Med. 239: 664 (Oct. 28); 239: 709 (Nov. 4); 239: 743 (Nov. 11) 1948. CrossrefMedlineGoogle Scholar15. Imler AE: Reticulo-endotheliosis with report of two cases, Am. J. Roentgenol. 56: 343, 1946. Google Scholar16. CurrensPopp JHWC: Xanthomatosis, Hand-Schüller-Christian type; report of a case with pulmonary fibrosis, Am. J. M. Sc. 205: 780, 1943. CrossrefGoogle Scholar17. RaganHowesPlotzMeyerBluntLattes CELCMKJWR: The effect of ACTH and cortisone on connective tissue, Bull. New York Acad. Med. 26: 251, 1950. MedlineGoogle Scholar18. Fischel EE: The relationship of adrenal cortical activity to immune responses, Bull. New York Acad. Med. 26: 255, 1950. MedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: *Received for publication March 12, 1951.From the Medical Service, Wadsworth Hospital, Veterans Administration Center, Los Angeles 25, California.Reviewed by the Veterans Administration and published with the approval of the Chief Medical Director. The statements and conclusions of the authors are the result of their own study and do not necessarily reflect the opinion or policy of the Veterans Administration. 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BUECHNER, M.D., F.A.C.P., RONALD FISHMAN, M.D.Cortisone and X-ray Treatment of Hand-Schüller-Christian's SyndromeCHRONIC, DISSEMINATED, NONLIPOID RETICULOENDOTHELIOSIS (HISTIOCYTOSIS X): TREATMENT WITH CORTICOTROPIN AND ANTIBIOTICS, WITH REPORT OF TWO CASES*PAUL H. MORTON, M.D., F.A.C.P.Chronic disseminated histiocytosis X (Schüller-Christian disease) with pulmonary involvement and impairment of alveolar-capillary diffusionEOSINOPHILIC GRANULOMA OF THE LUNGThe use of cortisone in the treatment of reticuloendotheliosisThe management of certain nonlipid reticulo-endotheliosesDie angeborenen Stoffwechselanomalien des Menschen 1 October 1951Volume 35, Issue 4Page: 927-937KeywordsBoneHydrocephalusLesionsLiverLungsMedical servicesRadiation therapySkullSpleenUpper respiratory tract infections ePublished: 1 December 2008 Issue Published: 1 October 1951 PDF downloadLoading ...