RESULTS OF THE USE OF EXTRACT OF THE INTESTINAL MUCOSA IN THE TREATMENT OF VASOMOTOR RHINITIS
Authors: Louis E. Prickman, Harold I. Lillie, Grace M. Roth, Ralph G. Fleming
Journal: Annals of Internal Medicine (1940)

Article1 June 1940RESULTS OF THE USE OF EXTRACT OF THE INTESTINAL MUCOSA IN THE TREATMENT OF VASOMOTOR RHINITISLOUIS E. PRICKMAN, M.D., F.A.C.P., HAROLD I. LILLIE, M.D., GRACE M. ROTH, PH.D., RALPH G. FLEMING, M.D.LOUIS E. PRICKMAN, M.D., F.A.C.P.Search for more papers by this author, HAROLD I. LILLIE, M.D.Search for more papers by this author, GRACE M. ROTH, PH.D.Search for more papers by this author, RALPH G. FLEMING, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-13-12-2235 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptFor many years it has been suspected that histamine has a rôle in the allergic reaction. If this is true, a substance having the ability to detoxify histamine would seem to have useful therapeutic possibilities in the treatment of allergic conditions. An intestinal extract† said to have such detoxifying properties against histamine, has been supplied to us for therapeutic trial in the treatment of allergic conditions and this paper deals with our preliminary clinical observations in the use of this product.Only a few of many important experimental and clinical observations on the rôle of histamine in relation to allergy...References1. DALELAIDLAW HHPP: The physiological action of β-iminazolylethylamine, Jr. Physiol., 1910, xli, 318-344. CrossrefGoogle Scholar2. LEWISGRANT TRT: Vascular reactions of the skin to injury: Part II. The liberation of a histamine-like substance in injured skin; the underlying cause of factitious urticaria and of wheals produced by burning; and observations upon the nervous control of certain skin reactions, Heart, 1924, xi, 209-265. Google Scholar3. HARE R: An experimental investigation into the vascular reactions of the susceptible skin to protein, Heart, 1926, xiii, 227-238. Google Scholar4. LEWIS T: The blood vessels of the human skin and their responses, 1927, Shaw & Sons, Ltd., London, 322 pp. Google Scholar5. DALE HH: Some chemical factors in the control of the circulation, Lancet, 1929, i, 1285-1290. Google Scholar6. CODEING CFHR: The isolation of histamine from the white cell layer of centrifuged rabbit blood, Jr. Physiol., 1937, xc, 501-510. CrossrefGoogle Scholar7. CODE CF: Unpublished data. Google Scholar8. BEST CH: The disappearance of histamine from autolysing lung tissue, Jr. Physiol., 1929, lxvii, 256-263. CrossrefGoogle Scholar9. BESTMCHENRY CHEW: The inactivation of histamine, Jr. Physiol., 1930, lxx, 349-372. CrossrefGoogle Scholar10. ROTHHORTON GMBT: Hypersensitiveness to cold; treatment with histamine and histaminase: report of case, Proc. Staff Meet., Mayo Clin., 1937, xii, 129-133. Google Scholar11. FOSHAYHAGEBUSCH LOE: Serum sickness; effective treatment and probable prophylaxis by means of histaminase. Read before the Central Society for Clinical Research, Chicago, Illinois, November 5, 1938. Google Scholar12. ADELSBERGER L: Darmextrakte bei allergischen Krankheiten, Fortschr. d. Therap., 1937, xiii, 568-575. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Rochester, Minnesota*Submitted for publication February 13, 1939.†The extract used in this study was courteously supplied by the Department of Medical Research, Winthrop Chemical Co. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byHistaminase in the treatment of allergy in childrenHistaminase in allergy: A study of its effects on skin reactivity to histamine and to allergens 1 June 1940Volume 13, Issue 12Page: 2235-2240KeywordsAllergy and immunologyClinical trialsHistamineMucous membranesRespiratory system proceduresRhinitis ePublished: 1 December 2008 Issue Published: 1 June 1940 PDF downloadLoading ...