tbuckley/cabot-search huggingface dataset:
Pollen food syndrome in a teenage student
Authors: E. Angier, A. Sheikh
Journal: BMJ (2010)

A first year university student comes to see you with a history of itching and mild lip swelling after eating apples and pears. She has also noticed tingling in her mouth after eating nuts. ### Detailed history is the cornerstone of diagnosis Pollen food syndrome (also known as oral allergy syndrome) comprises a set of symptoms usually involving itching and mild swelling—typically limited to the oropharynx—after eating raw fruits, vegetables, peanuts, nuts, and sometimes spices (box 1). The range of symptoms can be wide and may include anaphylaxis, although this is uncommon. The symptoms are due to an immediate (IgE mediated type 1) hypersensitivity reaction typically caused by cross-reactivity between the protein found in these foods and those in pollens. Symptoms are therefore predictable, beginning within minutes of exposure. Affected people are able to tolerate these foods when cooked because the allergen responsible is heat labile. #### Box 1 Foods commonly implicated in pollen food syndrome1
Acute and Chronic Effects of Dysfunction of Right Ventricular Outflow Tract Components on Right Ventricular Performance in a Porcine Model
Authors: Thierry Bove, Stefaan Bouchez, Stefan De Hert, Patrick Wouters, Filip De Somer, Daniel Devos, Pamela Somers, Guido Van Nooten
Journal: Journal of the American College of Cardiology (2012)
TREATMENT OF VASOMOTOR RHINITIS* WITH INTRANASAL DISODIUM CROMOGLYCATE (SCG)
Authors: THORVALD LÖFKVIST, HANS RUNDCRANTZ, GUNNAR SVENSSON
Journal: Allergy (1977)

The effect of SCG powder (Lomudalr, Intalr) intranasally in vasomotor rhinitis has been studied on 49 adult volunteers in a double-blind cross-over study during 13 weeks in January--April 1973. The dose of SCG was 40 mg/day. Although a substantial number of results were obtained, no significant difference between the effects of SCG and placebo treatment, on variables measured, was detected. However, some patients experienced relief with, and preferred, the treatment with SCG. The results from this investigation are discussed in comparison with those from other studies including patients with vasomotor rhinitis.
HIV/AIDS in the Caribbean
Authors: R Voelker
Journal: JAMA (2001)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
257. AAV Vector-Loading DC with an Autoimmune Domain-Depleted HCV Core Gene Stimulates High Anti-Core and Low Anti-Self CTL
Authors: Maurizio Chiriva-Internati, Yong Liu, Rongcheng Luo, Changxuan You, Paul L. Hermonar
Journal: Molecular Therapy (2004)

Background: Many cases of chronic hepatitis C virus (HCV) infection are resistant to conventional therapies.
THE INTRADERMAL TUBERCULIN TEST IN NON-TUBERCULOUS ADULTS
Authors: S. L. Cummins, A. C. Evans
Journal: BMJ (1933)

MEBRABIoTIHAL 815 cas? the tumour disappeared completely, leaving an almost normal breast.These results compare very favourably with those obtained by amputation.In the inoperable cases, where no alternative method ot treatment was possible, the results quite exceeded expectation; large fungating masses disappeared, and ulcerating surfaces healed over.As most of the patients were 70 years of age or more, this was really all that one could ask, and in the majority of cases the patient was saved from a distressing condition.It is remarkable, however, that even at the age of 86, extensive generaliza- tion can occur.It would, of course, have been impossible if the ulcer had not been treated, since the patient would have died of exhaustion.It will be sean, then, that in inoperable cases radium can give a relief which cannot ba otherwise obtained.In advanced cases the evidence seems to show that radium can give results at least as good as those obtained by amputation, at the cost of far less inconvenience and with no disfigurement.In early cases it may certainly be
The Clinical Encounter: A Guide to the Medical Interview and Case Presentation
Authors: J. Andrew Billings, John D. Stoeckle
Journal: Annals of Internal Medicine (1990)

PART 1: A GUIDE TO THE INTERVIEW 1. Overview 2. Beginning the Interview and Establishing a Relationship: 3. Eliciting Information for Diagnosis and Management I: The Interviewing Process 4. Eliciting Information for Diagnosis and Management II: The Content of the Medical Interview 5. More Interviewing Techniques 6. Consulting With Your Preceptor 7. The Exposition Phase: Informing and Counseling the Patient 8. Recording 9. Readings PART 2: ADVANCED TOPICS 10. More Tactics for Eliciting Information 11. Learning From Hearing and Seeing Yourself 12. The Mental Status Examination 13. Difficult Relationships 14. Carrying Out A Plan 15. The Return Visit 16. Home Visits and Functional Assessment 17. The Medical Record 18. Oral Case Presentation 19. Collaborative Care 0Afterword: A History of History Taking Appendix A: Complete Case Write-up Appendix B: Sample Problem List Appendix C: A Basic Outpatient Medical History Form Appendix D: Criteria for Case Write-ups
Photo diagnosis can cut waiting times for dermatology
Authors: Dobson Roger
Journal: BMJ (2004)

Dermatology waiting times could be substantially reduced if GPs took instant photographs of their patients' visible symptoms and included them in referral letters.

When GPs were given cameras to take instant pictures of skin conditions, the number of patients needing to see a dermatologist was cut by 25%, a report in Family Practice says (2004:21:54-6).

And for more than 60% of patients who had a “photo diagnosis,” a management plan was made without the patient needing an appointment with a specialist before diagnosis. The mean time for drawing up …
Abstract 18902: Adaptive Servo-ventilation is More Effective in Dilated Cardiomyopathy Patients than Ischemic Cardiomyopathy Patients and Heart Failure with Preserved Ejection Fraction Patients
Authors: Tatsunori Ikeda, Manabu Fujimoto, Masakazu Yamamoto, Kazuyasu Okeie, Hisayoshi Murai, Soichirou Usui, Masayuki Takamura, Shuichi Kaneko
Journal: Circulation (2014)

Introduction: Central sleep apnea (CSA) is a common complication in heart failure patients (HF) and closely associated with poor prognosis. Adaptive servo-ventilation (ASV) is a new treatment for HF with CSA. Some study indicated ASV might improve cardiac function and its prognosis. However, there was little discussion by each background disease. Methods and Results: We examined 64 HF with CSA patients (involving 15 dilated cardiomyopathy (DCM) patients, 27 ischemic cardiomyopathy (ICM) patients, and 22 heart failure with preserved ejection fraction (HFpEF) patients) treated with ASV who had not been admitted to the hospital due to worsening HF in the 6 months before initiating ASV therapy. During 1 and 6 months observation, apnia-hypopnea index and brain natriuretic peptide were decreased significantly than baseline in all groups. There was similar in left ventricular ejection fraction in ICM and HFpEF groups during observation, however, in DCM group, there was significantly improved (29.3 +/- 14.3 to 36.5 +/- 12.4, and to 40.5 +/- 14.9%, P&lt;0.01 compared with baseline). And left ventricular end systolic diameter was significantly shortened (53.7 +/- 11.1 to 30.4 +/- 11.5, and to 47.6 +/- 12.0 mm, P&lt;0.01 compared with baseline), in spite of left ventricular end diastolic diameter was not changed. Conclusions: These results indicate that ASV is more effective in DCM patient with modifying hemodynamics and cardiac function than ICM and HFpEF patients.
443. Incorporating the Survivin Promoter in an Infectivity Enhanced CRAd-Analysis of Oncolysis in Five Different Cancer Cell Lines
Authors: Eunhee Kim, Taeyoung Koo, Dae-Bong Kang, Il-Kyu Choi, Joo-Hyuk Sohn, Chae-Ok Yun, Joo-Hang Kim
Journal: Molecular Therapy (2004)

Replication-competent adenoviruses (Ad) are a promising new modality for the treatment of cancer. Selective replication of viral agents in tumor may lead to improved efficacy over non-replicating adenoviruses due to their inherent ability to multiply, lyse and spread to surrounding cells. We have previously shown that the E1B 55kDa-deleted adenovirus (YKL-1) exhibits tumor specific replication and cell lysis, but its cytolytic effects were reduced in comparison to the wild type adenovirus. To increase the oncolytic potency of YKL-1, we have reintroduced the adenovirus death protein (ADP) gene under the control of either the CMV or the MLP promoter at the E3 region of YKL-1, generating YKL-cADP and YKL-mADP adenovirus, respectively. ADP is an 11.6kDa protein encoded by the E3 transcription unit, and is required to efficiently kill adenovirus-infected cells. However to date, the mechanism by which ADP mediates cell death has not been clearly defined. In this study, we report that ADP-overexpressing Ad markedly enhanced cytolytic effect (up to 100-fold) against all tumor cell lines tested, but did not increase CPE in normal skin fibroblast, BJ. Moreover, plaque size formed by YKL-cADP was substantially larger than that of YKL-1, indicating enhancement in cell lysis. TUNEL assay and Annexin-V/PI double staining indicate that ADP-mediated cytotoxicity was largely driven by apoptosis. Finally, YKL-cADP adenovirus also showed superior antitumor effect than YKL-1 and YKL-mADP in C33A cervical and Hep3B hepatoma xenograft tumor models. Taken together, these lines of evidence demonstrate that the newly generated adenovirus expressing ADP under the CMV promoter induces efficient but tumor selective cell lysis, which is critical for adding therapeutic value to replicating adenovirus for cancer gene therapy.
Abstract 01: Diabetes is a Risk Factor for 20-year Cognitive Decline
Authors: Andreea M Rawlings, A. Richey Sharrett, Josef Coresh, Marilyn Albert, David J Couper, Michael Griswold, Rebecca F Gottesman, Lynne Wagenknecht, B. Gwen Windham, Elizabeth Selvin
Journal: Circulation (2014)

Introduction: Most studies examining the association between diabetes and cognitive decline have been among older individuals and/or have had limited follow-up. We undertook this study to examine the association of diabetes in mid-life with long-term change in cognitive function in a community-based population of blacks and whites. Hypothesis: We hypothesized that diabetes and chronic hyperglycemia - as measured by HbA1c at baseline - would be associated with 20-year cognitive decline. Methods: We used generalized estimating equations to examine the association of diabetes at baseline (1990-1992, aged 48-67 years) with 20-year change in cognitive performance among 13015 (24% black; 55% female; 1205 with diabetes) ARIC participants. Delayed Word Recall, Digit Symbol Substitution, and Word Fluency were used to assess cognitive performance, and were summarized using a global Z score. Self-reported diagnosis or diabetes medication use at baseline was used to assess diabetes and HbA1c was categorized using clinical cutpoints. Models were adjusted for demographic and clinical variables. Results: Diagnosed diabetes was associated with significantly more cognitive decline compared to persons without diabetes (Z = -0.17, 95% CI: -0.26, -0.07) (Figure). This represents 19% faster decline compared to persons without diabetes. We also observed a significant trend in decline among clinical categories of HbA1c, even below the threshold for diagnosis of diabetes. Results were similar in race-stratified analyses. In addition, among white participants poorly controlled diabetes (HbA1c&gt;7) had significantly more decline compared to persons whose diabetes was controlled (Z = -0.24 (95% CI: -0.46, -0.02)). Conclusions: Diabetes in middle-age was associated with substantially more rapid cognitive decline across 20 years of follow-up. Our results also suggest that pre-diabetes and poor control of diabetes lead to greater cognitive decline.
Abstract 13293: Acyl-coa Binding Protein is Marker of Myocardial Ischemia
Authors: Xu Shi, Gregory Lewis, Michelle Keyes, Laurie Farrell, Steven Carr, Hasmik Keshishian, Michelle O’Donoghue, Marc Sabatine, Robert Gerszten
Journal: Circulation (2014)

Background: We recently applied a liquid chromatography tandem mass spectrometry (LC-MS/MS) based proteomics platform to plasma samples from individuals undergoing a “planned” myocardial infarction (PMI; alcohol ablation for hypertrophic cardiomyopathy) and identified acyl-CoA binding protein (ACBP) as a potential circulating biomarker of myocardial injury. ACBP is a 10 kDa intracellular protein that is highly expressed in cells with a high turn-over of fatty acids such as cardiomyocytes. We sought to determine the site of ACBP release and whether ischemia alone is sufficient to trigger an increment in plasma levels in humans. Methods: Coronary sinus (CS) and peripheral venous samples were obtained simultaneously from PMI patients; peripheral venous samples were obtained from derivation/validation cohorts of subjects undergoing cardiac stress testing. Plasma ACBP levels were measured by immunoassay. Results: In PMI patients (n=11), pre-injury levels of ACBP were comparable in the CS and peripheral samples. As early as 10 min after PMI, ACBP levels were 27% higher in the CS than in the periphery (P = 0.01), and remained 30% higher at 60 minutes (P = 0.02). Next, we studied 105 patients undergoing cardiac stress testing, 52 of whom demonstrated inducible ischemia (cases) and 53 of whom did not (controls). Baseline ACBP levels were comparable in cases and controls. Changes in median ACBP levels after the exercise stress challenge were significantly greater in the ischemic patients (cases) than in the controls (22% increase in cases; 1% decrease in controls; P = 0.0001), findings which were validated in a second cohort of 101 patients subjects (P = 0.002). These findings remained significant in a multivariable model adjusting for age, male sex, diabetes, BMI, smoking, creatinine, hypercholesterolemia, and total minutes of exercise. By contrast, the effects of exercise on established biomarkers (cTnI, NT-proBNP and FABP) did not differ betwen cases and controls. Conclusions: We provide initial verification that ACBP is rapidly released from the injured heart and increases in response not only to infarction but also ischemia. These findings motivate additional clinical studies of this novel biomarker in heterogeneous patient cohorts.
Bronchial hyperresponsiveness as phenotypic feature of COPD
Authors: Irina Trofimenko, Boris Chernyak
Journal: European Respiratory Journal (2011)

Bronchial hyperresponsiveness (BHR) in COPD applies to a pathophysiologic sign that can provide additional information about severity and features of disease.

Aim: To compare clinical-functional features and health-related quality of life (QL) in COPD depending on BHR level as phenotypic sign.

Methods: 75 moderate severe (II stage) COPD patients (66 male) mean age of 57 yrs were studied. COPD symptoms on the 5-score scale (MRC and Gulsvik, 1988), spirometry parameters, smoking (packs-years) and QL (SGRQ) were analyzed depending on the BHR in metacholine challenge. Criteria of positive BHR was provocative dose (PD20)<0,471 mg.

Results: By results of the methacholine challenge patients were divided into two groups: the 1-st positive test (PD20 0,471). BHR was revealed at 52 of 75 (69%) patients. Among them female presented 89%. Women had higher level BHR than men: PD20 0,024 mg vs 0,121 mg (p=0,01). The QL of the 1-st group was worse than the 2-nd group. The median difference of SGRQ domains between two groups worked out: Symptoms 24, Activity 14, Influence 13, Total 15 points (p<0,01 in all cases). The dyspnoea level corresponding to worse QL was higher in the 1-st group: the difference of mean was 0,8 points (p=0,0003). The mean of PD20 in patients with severe dyspnea was less in 2,2 times in comparison MRC dyspnea 1-2 grades (p=0,029). BHR contributes to formation of severe dyspnea in COPD: OR 8,6 (CI 1,6<OR<51,5; p=0,007). However no significant differences were found for FEV1 and smoking status.

Conclusion: A part of COPD patients, especially women have BHR. BHR modifies current of disease and promotes more severe dyspnea, worse QL of COPD patients with comparable value of FEV1.
Autologous plasma and serum skin test in chronic urticaria: reply from authors
Authors: H. Yıldız, O. Karabudak-Abuaf, B. Doğan, Y. Harmanyeri
Journal: British Journal of Dermatology (2011)

Journal Article Autologous plasma and serum skin test in chronic urticaria: reply from authors Get access H. Yıldız, H. Yıldız Department of Dermatology, Eskisehir Military Hospital, 26020 Eskisehir, Turkey Search for other works by this author on: Oxford Academic Google Scholar O. Karabudak‐Abuaf, O. Karabudak‐Abuaf Department of Dermatology, GATA Haydarpasa Teaching Hospital, 34664 Istanbul, Turkey Ozlem Karabudak‐Abuaf. E‐mail: okarabudak@yahoo.com Search for other works by this author on: Oxford Academic Google Scholar B. Doğan, B. Doğan Department of Dermatology, GATA Haydarpasa Teaching Hospital, 34664 Istanbul, Turkey Search for other works by this author on: Oxford Academic Google Scholar Y. Harmanyeri Y. Harmanyeri Department of Dermatology, Istanbul Bilim University, 34349 Istanbul, Turkey Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 166, Issue 6, 1 June 2012, Pages 1363–1364, https://doi.org/10.1111/j.1365-2133.2011.10780.x Published: 01 June 2012
An Investigation of the Oncogenic Activity of Two Representative Epoxy Resins
Authors: C. H. Hine, R. J. Guzman, M. M. Coursey, J. S. Wellington, H. H. Anderson
Journal: Cancer Research (1958)

An evaluation has been made of the oncogenic activity of two uncured epoxy resins. A liquid bisphenol-based epoxy resin produced no carcinomas in C3H mice when applied thrice weekly for 2 years in a concentration of 5 per cent. Carcinomas were produced by a liquid aliphatic epoxy resin at this level, but with a tumor potency of only 9 as compared with 264 for the positive control, 20-methylcholanthrene. The resins by subcutaneous injection in rats showed TT50 (time at which 50 per cent of the animals would be expected to carry tumors) of 100 and 157 weeks, and tumor potencies (10,000 divided by TT50 in days) of 14 and 9, respectively, as compared with a TT50 of 53 weeks and a tumor potency of 24 for 1,2,5,6-dibenzanthracene. Injection of either of these ressins, two solid bisphenol-based epoxy resins of higher molecular weight, or of diglycidyl resorcinol, poly(allyl glycidyl ether), or epoxodized soybean oil did not alter the incidence of pulmonary adenoma in strain A mice over a period of 16 weeks. Feeding 0.2 per cent of either liquid resin in the diet for 11 months also did not alter the incidence, nor did similar feeding for 16 weeks alter the incidence of induced tumors in mice pretreated with 20-methylcholanthrene.

On the basis of this study, the potential hazard of skin irritation or carcinogenesis would seem to be obviated by the ordinary good industrial hygiene practices.
Three-Year Survival Results From An Ongoing Phase 2 Study Of Brentuximab Vedotin In Patients With Relapsed Or Refractory Systemic Anaplastic Large Cell Lymphoma
Authors: Barbara Pro, Ranjana H. Advani, Pauline Brice, Nancy L. Bartlett, Joseph D. Rosenblatt, Tim Illidge, Jeffrey Matous, Radhakrishnan Ramchandren, Michelle A. Fanale, Joseph M. Connors, Yin Yang, Dirk Huebner, Dana A. Kennedy, Andrei R. Shustov
Journal: Blood (2013)
An Interleukin-33-Mast Cell-Interleukin-2 Axis Suppresses Papain-Induced Allergic Inflammation by Promoting Regulatory T Cell Numbers
Authors: Hideaki Morita, Ken Arae, Hirotoshi Unno, Kousuke Miyauchi, Sumika Toyama, Aya Nambu, Keisuke Oboki, Tatsukuni Ohno, Kenichiro Motomura, Akira Matsuda, Sachiko Yamaguchi, Seiko Narushima, Naoki Kajiwara, Motoyasu Iikura, Hajime Suto, Andrew N.J. McKenzie, Takao Takahashi, Hajime Karasuyama, Ko Okumura, Miyuki Azuma, Kazuyo Moro, Cezmi A. Akdis, Stephen J. Galli, Shigeo Koyasu, Masato Kubo, Katsuko Sudo, Hirohisa Saito, Kenji Matsumoto, Susumu Nakae
Journal: Immunity (2015)
Kurzwellentherapie: Die medizinische Anwendung elektrischer Höchstfrequenzen
Authors: Erwin Schliephake
Journal: JAMA (1935)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal