Successful Prevention of an Anaphylactoid Reaction to Iron Dextran
Authors: Leonard C. Altman
Journal: Annals of Internal Medicine (1988)

Letters and Corrections15 August 1988Successful Prevention of an Anaphylactoid Reaction to Iron DextranLeonard C. Altman, MD, Penny E. Petersen, MDLeonard C. Altman, MDSearch for more papers by this author, Penny E. Petersen, MDSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-109-4-346 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the Editor: The incidence of adverse systemic reactions to iron dextran is 3%; that of life-threatening reactions is 0.6% (1). We present a method for desensitization before iron dextran administration.A 26-year-old white man had chronic malabsorption and gastrointestinal blood loss resulting in iron deficiency anemia. His hematocrit was maintained at approximately 25 by frequent transfusions; his serum ferritin was 20 ng/mL (normal range, 25 to 100). Because he was unable to absorb oral iron, intravenous iron dextran therapy was attempted. After a test dose of 0.25 mL, he rapidly developed nausea, vomiting, pruritus, diffuse erythema, and tachycardia. Approximately...References1. HamstraBlockSchocket RMA. Intravenous iron dextran in clinical medicine. JAMA. 1980;243:1726-31. CrossrefMedlineGoogle Scholar2. HedinRichterRing HWJ. Dextran-induced anaphylactoid reactions in man. Int Arch Allergy Appl Immunol. 1976;52:145-59. CrossrefMedlineGoogle Scholar3. HeidelbergerAisenberg MA. Serological reactivity of synthetic poly-glucoses. Proc Nat Acad Sci USA. 1953;39:453-9. CrossrefMedlineGoogle Scholar4. RenckLjungstromHedinRichter HKHW. Prevention of dextran-induced anaphylactic reactions by hapten inhibition. Acta Chir Scand. 1983;149:355-60. MedlineGoogle Scholar5. SweeneyKlotzKaySteinfeldKlotz MLBLS. Imferon hypersensitivity reaction—demonstration of a high molecular weight dextran specific IgE [Abstract]. Ann Allergy. 1980:44:47. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: University of Washington Seattle, WA 98195 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byPractical Guidance for the Evaluation and Management of Drug Hypersensitivity: Specific DrugsIntravenous Iron Isomaltoside 1000 Reduces Postoperative Anemia in Patients Undergoing Elective Urologic Surgery and Those with UrosepsisCanadian expert consensus: management of hypersensitivity reactions to intravenous iron in adultsIron saltsHypersensitivity to intravenous iron: classification, terminology, mechanisms and managementIntroducing iron isomaltoside 1000 (Monofer(R))--development rationale and clinical experienceIron saltsSuccessful administration of iron dextran in a patient who experienced a life threatening reaction to intravenous iron dextranParenteral iron use in the management of anemia in end-stage renal disease patientsApproaches to the prophylaxis of anaphylactic reactions to dextran preparations on the basis of modern theories of the pathogenetic mechanisms of their developmentMetals 15 August 1988Volume 109, Issue 4Page: 346-347KeywordsBloodDextranErythemaFerritinHematocritIron deficiency anemiaNauseaPruritusTachycardiaVomiting Issue Published: 15 August 1988 PDF downloadLoading ...