tbuckley/cabot-search huggingface dataset:
New Diabetes Glucose Test
Authors: Bernard A. Schwetz
Journal: JAMA (2001)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Strategies of Clopidogrel Load and Atorvastatin Reload to Prevent Ischemic Cerebral Events in Patients Undergoing Protected Carotid Stenting
Authors: Giuseppe Patti, Fabrizio Tomai, Rosetta Melfi, Elisabetta Ricottini, Michele Macrì, Pietro Sedati, Arianna Giardina, Cristina Aurigemma, Mario Leporace, Andrea D'Ambrosio, Germano Di Sciascio
Journal: Journal of the American College of Cardiology (2013)
Progressive HHV-8-positive classic Kaposi's sarcoma: rapid response to interferon α-2a but persistence of HHV-8 DNA sequences in lesional skin
Authors: None Pfrommer, None Tebbe, None Tidona, None WÖlfer, None Krengel, None Zeichardt, None Zouboulis, None Orfanos
Journal: British Journal of Dermatology (1998)

Journal Article Progressive HHV‐8‐positive classic Kaposi's sarcoma: rapid response to interferon α‐2a but persistence of HHV‐8 DNA sequences in lesional skin Get access C. Pfrommer, C. Pfrommer Department of Dermatology, University Medical Centre Benjamin Franklin, The Free University of Berlin, Hindenburgdamm 30, D‐12200 Berlin, Germany, Search for other works by this author on: Oxford Academic Google Scholar B. Tebbe, B. Tebbe Department of Dermatology, University Medical Centre Benjamin Franklin, The Free University of Berlin, Hindenburgdamm 30, D‐12200 Berlin, Germany, Search for other works by this author on: Oxford Academic Google Scholar C.A. Tidona, C.A. Tidona Institute for Medical Virology, University of Heidelberg, Heidelberg, Germany Search for other works by this author on: Oxford Academic Google Scholar U. WÖlfer, U. WÖlfer Department of Dermatology, University Medical Centre Benjamin Franklin, The Free University of Berlin, Hindenburgdamm 30, D‐12200 Berlin, Germany, Search for other works by this author on: Oxford Academic Google Scholar S. Krengel, S. Krengel Department of Dermatology, University Medical Centre Benjamin Franklin, The Free University of Berlin, Hindenburgdamm 30, D‐12200 Berlin, Germany, Search for other works by this author on: Oxford Academic Google Scholar H. Zeichardt, H. Zeichardt Institute of Clinical and Experimental Virology, University Medical Centre Benjamin Franklin, The Free University of Berlin, Hindenburgdamm 30, D‐12200 Berlin, Germany, Search for other works by this author on: Oxford Academic Google Scholar CH.C. Zouboulis, CH.C. Zouboulis Department of Dermatology, University Medical Centre Benjamin Franklin, The Free University of Berlin, Hindenburgdamm 30, D‐12200 Berlin, Germany, Search for other works by this author on: Oxford Academic Google Scholar C.E. Orfanos C.E. Orfanos Department of Dermatology, University Medical Centre Benjamin Franklin, The Free University of Berlin, Hindenburgdamm 30, D‐12200 Berlin, Germany, Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 139, Issue 3, 1 September 1998, Pages 516–519, https://doi.org/10.1046/j.1365-2133.1998.02422.x Published: 01 September 1998
RESULTS FOLLOWING PULMONARY RESECTION OF TUBERCULOUS DISEASE WITH SPECIAL REFERENCE TO LOCALIZED NECROTIC LESIONS
Authors: James H. Forsee, Carl W. Tempel, Edwin L. Scott
Journal: Annals of Internal Medicine (1953)

Article1 September 1953RESULTS FOLLOWING PULMONARY RESECTION OF TUBERCULOUS DISEASE WITH SPECIAL REFERENCE TO LOCALIZED NECROTIC LESIONSJAMES H. FORSEE, CARL W. TEMPEL, EDWIN L. SCOTTJAMES H. FORSEESearch for more papers by this author, CARL W. TEMPELSearch for more papers by this author, EDWIN L. SCOTTSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-39-3-463 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptBACKGROUND FACTORS FOR EVALUATING THE PLACE OF RESECTION IN PULMONARY TUBERCULOSISPulmonary resection for active tuberculosis was seldom employed at Fitzsimons Army Hospital prior to the introduction of streptomycin; hence, follow-up studies must of necessity be limited to the period subsequent to 1946 (figure 1). A tenfold increase in the utilization of excisional surgery has occurred coincident with improvement of antituberculosis drug therapy and surgical technic during the past six years.Included in this report are those patients proved to have tuberculosis before operation, and those who submitted to thoracotomy primarily for diagnosis and then continued on treatment after the...Bibliography1. Mitchell RS: Late results of modified bed rest in active uncomplicated minimal pulmonary tuberculosis, Am. Rev. Tuberc. 67: 401 (Apr.) 1953. MedlineGoogle Scholar2. Waring JJ: Personal communication. Google Scholar3. ShieldsChapmanCarswellWollenman DOJSJOJ: Nodular tuberculosis, J. Thoracic Surg. 24: 568 (Dec.) 1952. CrossrefGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: *From the Symposium on Tuberculosis presented at the Thirty-Fourth Annual Session of the American College of Physicians, Atlantic City, New Jersey, April 15, 1953.From the Surgical, Medical and Laboratory Services, Fitzsimons Army Hospital, Denver, Colorado. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byZur minimalen Tuberkulose aus der Sicht des Röntgenologen 1 September 1953Volume 39, Issue 3Page: 463-470KeywordsDrug therapyLesionsPulmonary diseasesResearch laboratoriesStreptomycinSurgeryThoracotomy ePublished: 1 December 2008 Issue Published: 1 September 1953 PDF downloadLoading ...
Abstract A121: Suppression of orthotopic pancreatic cancer growth by sulforaphane is associated with activation of FOXO transcription factors
Authors: Wei Yu, Rakesh Srivastava, Sharmila Shankar
Journal: Cancer Research (2015)

Abstract FoxO (forkhead box O) transcription factors are crucial regulators of cell fate. This function of FoxO proteins relies on their ability to control diverse functions such as proliferation, differentiation, DNA repair and apoptosis. Constitutively active AKT and ERK in cancer cells have been shown to phosphorylate FoxO transcription factors (FKHR, FKHRL1 and AFX), which bind to protein 14-3-3 and sequester in the cytoplasm. In the absence of survival signals, FoxO proteins dephosphorylate, translocate to the nucleus and upregulate a series of target genes, thereby promoting cell cycle arrest and apoptosis. Sulforaphane a naturally occurring isothiocyanate, exerts anti cancer effects through diverse mechanisms. In this study we have shown that sulforaphane acts both by suppressing cell proliferation and inducing apoptosis in pancreatic tumors orthotopically implanted in nude mice. Sulforaphane regulates cell survival and cell death by modulating the expression of two interacting survival signaling pathways. The inhibition of PI3K/AKT and MEK/ERK pathways by sulforaphane resulted in the inhibition of cytoplasmic phosphorylation of FOXOs, and enhanced their nuclear translocation and transcriptional activities leading to apoptosis. Furthermore, deletion of FOXO1, FOXO3 and FOXO4 genes by shRNA abrogated sulforaphane-induced cell cycle arrest and apoptosis whereas the phosphorylation deficient triple mutants of FOXOs enhanced sulforaphane-induced FOXO transcriptional activity and apoptosis by nuclear translocation of FOXO. Sulforaphane-treated mice showed significant inhibition in tumor growth which was associated with reduced phosphorylation of ERK, PI3K, AKT, FOXO1 and FOXO3a, cyclin D1 and induction of FOXO’s target genes Bim, p21/CIP1, and p27/KIP1. These data suggest that inhibition of ERK and AKT pathways act together to activate FOXO transcription factors which are involved in sulforaphane-mediated pancreatic tumor growth suppression, thus supporting the use of sulforaphane as a chemopreventive agent for the treatment of pancreatic cancer. Citation Format: Wei Yu, Rakesh Srivastava, Sharmila Shankar. Suppression of orthotopic pancreatic cancer growth by sulforaphane is associated with activation of FOXO transcription factors. [abstract]. In: Proceedings of the AACR Special Conference on Pancreatic Cancer: Innovations in Research and Treatment; May 18-21, 2014; New Orleans, LA. Philadelphia (PA): AACR; Cancer Res 2015;75(13 Suppl):Abstract nr A121.
Health Economics: An Introduction to Economic Evaluation, by Gisela Kobelt Economic Evaluation in Health Care, by Tom Jefferson, Vittorio Demicheli, Miranda Mugford
Authors: F. Bradley
Journal: BMJ (1997)

Gisela Kobelt Office of Health Economics, £2, pp 36

Tom Jefferson, Vittorio Demicheli, Miranda Mugford BMJ Publishing, £14.95, pp 118 ISBN 0 7279 1074 4

For me, health economics has been one of those subjects a bit like statistics–worthy and important but not immediately gripping and often shrouded in unintelligible jargon. However, recent emphasis on purchasing and providing in the organisation of health care, the debate about rationing in the health services, and the increasing importance of economic evaluation in research have highlighted the need for understanding and using …
Abstract 13301: Methylome-wide Association With Soluble Cell Adhesion Molecules Among Monozygotic Twins
Authors: Yan Sun, Jack Goldberg, Dean P Jones, Viola Vaccarino
Journal: Circulation (2014)

Introduction: Inflammation plays a critical role in the pathogenesis of cardiovascular disease. Epigenetic mechanisms, including DNA methylation (DNAm), is critical in the regulation of inflammatory genes, and can be influenced by inflammation. The soluble form of cell adhesion molecules, including vascular adhesion molecule 1 (sVCAM1), intercellular adhesion molecule 1 (sICAM1), and P-selectin (sP-selectin), are established biomarkers for inflammation and endothelial function, and are linked to cardiovascular events. Methods: To identify epigenetic markers associated with inflammation and endothelial function, we conducted a methylome-wide association study and investigated over 480,000 DNAm sites of peripheral blood cells from 140 monozygotic (MZ) middle-aged male twins from the Emory Twin Study. Results: Using two randomly selected subsets consisting of unrelated subjects, we identified and replicated 69 and 23 DNAm sites significantly associated with sVCAM1, and sICAM1 respectively, adjusted for multiple testing, but none for sP-selectin. All 23 sICAM1-associated DNAm sites were also associated with sVCAM1, including sites on gene ANKRD11 (P=1.51х10-21, 2.62х10-20), KDM2B (P=1.52х10-21, 9.13х10-17), CAPS (P=2.81х10-20, 3.17х10-18), and CUX1 (P=7.63х10-20, 2.84х10-19). They jointly explained 54% and 40% of variance in sVCAM1 and sICAM1 respectively. Two DNAm sites, located on UNC5D and TMEM125, were also significant comparing MZ twins who were phenotypically discordant for both sICAM1 (P=1.79х10-7, 2.78х10-6) and sVCAM1 (P=1.70х10-9, 1.71х10-7). Conclusions: These results suggest that sVCAM1 and sICAM1, but not sP-selectin, may share common pathophysiology in inflammation and endothelial function via an epigenetic mechanism in leukocytes. In addition, the epigenetic association with inflammation may be driven by unshared environmental exposures.
IN THE SPIRIT OF SERVICE
Authors: Wm. J. Kerr
Journal: Annals of Internal Medicine (1939)

Article1 May 1939IN THE SPIRIT OF SERVICEWM. J. KERR, F.A.C.P.WM. J. KERR, F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-12-11-1739 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail Excerpt"Where there is love of the art there also the love of man is"—HippocratesAs members of the medical profession, we are becoming increasingly conscious that all is not well in our house. Doubts are being implanted in the minds of laymen concerning the efficacy of established practices which organized medicine has set up for the protection of society. Propaganda for the socialization of medical services is encountered on every hand. The motives for professional objection to even the most fantastic schemes for providing medical care are misunderstood.There has never been a time when the medical profession has had... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: American College of Physicians San Francisco, California*Presented at the New Orleans meeting of the American College of Physicians, March 29, 1939.It should be understood that any statements or comments made in this address or any opinions given are entirely personal and do not necessarily reflect the consensus of opinion of the membership of the American College of Physicians. It is not implied that the College has taken any action or intends to take any official action for the solution of any of the problems discussed. Nextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 May 1939Volume 12, Issue 11Page: 1739-1750KeywordsMedical services ePublished: 1 December 2008 Issue Published: 1 May 1939 Copyright & PermissionsCopyright, 1939, by The American College of PhysiciansPDF downloadLoading ...
Repeated Exposure to High‐Frequency Low‐Amplitude Vibration Induces Degeneration of Murine Intervertebral Discs and Knee Joints
Authors: Matthew R. McCann, Priya Patel, Michael A. Pest, Anusha Ratneswaran, Gurkeet Lalli, Kim L. Beaucage, Garth B. Backler, Meg P. Kamphuis, Ziana Esmail, Jimin Lee, Michael Barbalinardo, John S. Mort, David W. Holdsworth, Frank Beier, S. Jeffrey Dixon, Cheryle A. Séguin
Journal: Arthritis & Rheumatology (2015)

High-frequency, low-amplitude whole-body vibration (WBV) is being used to treat a range of musculoskeletal disorders; however, there is surprisingly limited knowledge regarding its effect(s) on joint tissues. This study was undertaken to examine the effects of repeated exposure to WBV on bone and joint tissues in an in vivo mouse model.Ten-week-old male mice were exposed to vertical sinusoidal vibration under conditions that mimic those used clinically in humans (30 minutes per day, 5 days per week, at 45 Hz with peak acceleration at 0.3g). Following WBV, skeletal tissues were examined by micro-computed tomography, histologic analysis, and immunohistochemistry, and gene expression was quantified using real-time polymerase chain reaction.Following 4 weeks of WBV, intervertebral discs showed histologic hallmarks of degeneration in the annulus fibrosus, disruption of collagen organization, and increased cell death. Greater Mmp3 expression in the intervertebral disc, accompanied by enhanced collagen and aggrecan degradation, was found in mice exposed to WBV as compared to controls. Examination of the knee joints after 4 weeks of WBV revealed meniscal tears and focal damage to the articular cartilage, changes resembling osteoarthritis. Moreover, mice exposed to WBV also demonstrated greater Mmp13 gene expression and enhanced matrix metalloproteinase-mediated collagen and aggrecan degradation in articular cartilage as compared to controls. No changes in trabecular bone microarchitecture or density were detected in the proximal tibia.Our experiments reveal significant negative effects of WBV on joint tissues in a mouse model. These findings suggest the need for future studies of the effects of WBV on joint health in humans.
Abstract 12186: Correlations Between Sleep Disordered Breathing Indexes and Cardiac Functional Parameters in Patients With Chronic Heart Failure
Authors: Tadamitsu Nakashima, Tomoko Ohkusa, Tomoko Nao, Noriko Harada, Yasuaki Wada, Takeshi Ueyama, Shigeki Kobayashi, Yasuhiro Ikeda, Hiroyuki Sawatari, Akiko Chishaki, Shin-ichi Ando, Masafumi Yano
Journal: Circulation (2014)

Background and Purpose:  High prevalence of sleep disordered breathing (SDB) in patients with chronic heart failure (CHF) was reported. In general, apnea hypopnea index (AHI) is used as a severity of SDB index. On the other hand, it was reported there was not good correlation between AHI and prognosis in CHF patients with SDB. The purpose of this study was to investigate the correlations between cardiac functional characteristics and indexes of SDB severity [AHI, 3% oxygen desaturation index (ODI), and averaged time desaturation summation index (TDSI)] in CHF patients.   Methods:  One hundred thirty-six consecutive CHF patients, who were hospitalized from June 2012 to March 2014, were screened at their stable phase. Sleep studies were performed by in-hospital overnight full polysomnograpy (PSG). The following equation was used to determine TDSI. TDSI=total sleep time x (100-mean oxygen saturation).   Results:  The mean age was 68±14 years, and 81 men. Underlying etiology was ischemic cardiomyopathy (ICM) in 33 patients (24%), non-ICM in 64 (47%), and others in 39 (29%). Patients presented with an average NYHA class of 2.2±0.7 and a left ventricular ejection fraction (LVEF) of 46.9±17.9%. 73% of patients had obstructive sleep apnea (OSA) and 15% central sleep apnea (CSA). There was a statistical significant correlations between AHI and 3%ODI (r=0.907), between AHI and TDSI (r=0.438), and between TDSI and 3%ODI (r=0.514). There were no significant correlations between each index and cardiac functional parameters (BNP, LVEF, pulmonary arterial pressure, DcT, and E/e’). In 46 patients with LVEF   Conclusions:  In stable CHF patients, there were no significant correlations between SDB indexes (AHI, 3%ODI, and TDSI) and cardiac function parameters. These results indicate that we need to investigate more useful SDB indexes which reflect accurate pathophysiological conditions of patients with CHF.
Abstract P424: Prospective Associations of Serum 25-hydroxyvitamin D and Parathyroid Hormone with Arterial Function among Older Adults
Authors: Adriana J van Ballegooijen, Ilse Reinders, Stefan Pilz, Jacqueline M Dekker, Giel Nijpels, Coen D Stehouwer, Marjolein Visser, Ingeborg A Brouwer
Journal: Circulation (2014)

Introduction: Low vitamin D and high parathyroid hormone (PTH) concentrations have been associated with higher risk of cardiovascular disease in the general population. The mechanisms by which lower 25-hydroxyvitamin D (25OHD) -an established marker of vitamin D status- and PTH excess may confer vascular risk remain largely unknown. Hypothesis: We tested the hypothesis whether lower 25-hydroxyvitamin D (25OHD) and higher parathyroid hormone (PTH) concentrations are individually, and in combination, associated with arterial function measures, both cross-sectionally and after 8 years of follow-up in older adults. Methods: We used data from the Hoorn Study a prospective population-based cohort in the Netherlands. We included 535 participants for cross-sectional analyses with baseline measurements obtained between 2000- 2001, and 291 participants for longitudinal analyses with follow-up measurements obtained between 2007-2009. Serum 25OHD and intact PTH concentrations were measured using immunoassays. Outcomes were carotid-femoral pulse wave velocity and augmentation index. We used multivariate linear regression analyses for season-and-sex specific 25OHD and PTH quartiles to calculate regression coefficients. Results: Mean age at baseline was 70±6.3 years, and 50% were female. Median 25OHD was 54.2 nmol/L (interquartile range: 26.2-82.2) and median PTH 6.1 pmol/L (3.8-8.4). Mean pulse wave velocity and augmentation index were 10.0±3.0 (m/s) and 20.7±8.2 (%), respectively. In cross-sectional analyses, the lowest 25OHD quartile compared with the highest was associated with greater pulse wave velocity; however, the associations attenuated after adjustments 0.6 (95% CI -0.1, 1.3). In longitudinal analyses, neither 25OHD nor PTH was associated with greater pulse wave velocity and augmentation index. The results of the combination of low 25OHD and high PTH revealed no significant associations with arterial function measures. Conclusions: Among older adults, serum 25OHD and PTH concentrations were not associated with arterial function measures. Cardiovascular risk associated with low 25OHD and high PTH may not be explained by arterial stiffening or wave reflections.
Laboratory tests for paroxysmal nocturnal hemoglobinuria
Authors: Meir Preis, Christopher H. Lowrey
Journal: American Journal of Hematology (2013)

Paroxysmal nocturnal hemoglobinuria (PNH) is a rare hematological disorder that is often suspected in a patient presenting with non-immune hemolytic anemia associated with pancytopenia or venous thrombosis. This disorder is a consequence of acquired somatic mutations in the phosphatidylinositol glycan class A (PIG-A) gene in the hematopoietic stem cells (HSC) of patients. The presence of these mutations leads to production of blood cells with decreased glycosyl phosphatidylinositol-anchored cell surface proteins, making red blood cells derived from the clone more sensitive to complement mediated hemolysis. The diagnosis of PNH may be difficult in some cases due a low proportion of PNH cells in the blood and occasionally due to difficulties in selecting the most appropriate diagnostic studies. The latest generation of tests allow for detection of very small populations of PNH cells, for following the natural course and response to therapy of the disease, and for helping to decide when to initiate therapy with monoclonal antibody targeting the terminal complement protein C5 (Eculizumab), anticoagulation, and in some cases allogeneic HSC transplant. In this article, we review the different diagnostic tests available to clinicians for PNH diagnosis.
Neurolymphomatosis Diagnosed by 18F-FDG PET-CT
Authors: Liesbeth P. Salm, Bernies Van der Hiel, Marcel P. M. Stokkel
Journal: Clinical Nuclear Medicine (2012)

Neurolymphomatosis is defined as infiltration of the nervous system by hematological malignancy and is difficult to diagnose. We report a case of a 57-year-old man, treated for small B-cell non-Hodgkin lymphoma, presenting with sensorimotor impairment of the lower limbs, which started 6 years after diagnosis. He was treated with chemotherapy, after which, the symptoms disappeared. After 7 months, he developed sensorimotor impairment of both upper limbs. MRI of the brachial plexus showed no abnormalities. 18F-FDG PET-CT showed increased uptake at the brachial plexus and nerves, suggesting neurolymphomatosis. Confirmatory biopsy revealed conversion of the malignancy to diffuse large B-cell lymphoma.
Abstract 17525: Mutations in the Transcriptional Cofactor Eya4 Cause Age-Dependent Onset of Adverse Cardiac Physiology and Heart Failure
Authors: Tatjana Williams, Moritz Hundertmark, Peter Nordbeck, Sabine Voll, Melanie Muehlfelder, Jost Schoenberger, Oliver Ritter
Journal: Circulation (2013)
2 Ardışık Olguda, Kolorektal Epitelyal Neoplazmlar İçin Yapılan Endoskopik Submukozal Diseksiyonun Sonuçları
Authors: Mitsuhiro Fujishiro, Naohisa Yahagi, Naomi Kakushima, Shinya Kodashima, Yosuke Muraki, Satoshi Ono, Nobutake Yamamichi, Ayako Tateishi, Masashi Oka, Keiji Ogura, Takao Kawabe, Masao Ichinose, ve Masao Omata
Journal: Clinical Gastroenterology and Hepatology (2007)