FAT ABSORPTION AND PANCREATIC FUNCTION IN DIABETES MELLITUS
Authors: H S AKTAN, A P KLOTZ
Journal: Annals of Internal Medicine (1958)

Article1 October 1958FAT ABSORPTION AND PANCREATIC FUNCTION IN DIABETES MELLITUSHAMDI S. AKTAN, M.D., ARTHUR P. KLOTZ, M.D.HAMDI S. AKTAN, M.D.Search for more papers by this author, ARTHUR P. KLOTZ, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-49-4-820 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptAbnormalities in the exocrine secretion of the pancreas following intravenous secretin stimulation1, 4, 13, 14 and defective fat absorption as a rare complication of diabetes mellitus3, 10 have been previously reported. Acinar sclerosis and visceral neuropathy were thought to be responsible for these respective findings. Such recorded observations led us to a combined study of fat absorption and exocrine function of the pancreas in a controlled group of diabetic patients. Two of these were complicated by nocturnal diarrhea.MATERIALS AND METHODSStudies were carried out on 10 selected control patients and 10 diabetic patients. Two of the control cases had...Bibliography1. ÅgrenLagerlöfBerglund GHH: Secretin test of pancreatic function in diagnosis of pancreatic disease, Acta med. Scandinav. 90: 224, 1936. CrossrefGoogle Scholar2. BargenBollmanKepler JAJLEJ: Diarrhea of diabetes and steatorrhea of pancreatic insufficiency, Proc. Staff Meet., Mayo Clin. 11: 737, 1936. Google Scholar3. BergeWollaegerScholzRookeSprague KGEEDAEDRG: Steatorrhea complicating diabetes mellitus with neuropathy, report of cases without apparent external pancreatic insufficiency, Diabetes 5: 25, 1956. CrossrefMedlineGoogle Scholar4. DiamondSiegel JSSA: The secretin test in the diagnosis of pancreatic diseases with a report of 130 tests, Am. J. Digest. Dis. 7: 435, 1940. CrossrefGoogle Scholar5. Dreiling DA: Studies in pancreatic function. IV. The use of the secretin test in the diagnosis of tumors in and about the pancreas, Gastroenterology 18: 184, 1951. CrossrefMedlineGoogle Scholar6. DreilingHollander DAF: Studies in pancreatic function. II. A statistical study of pancreatic secretion following secretin in patients without pancreatic disease, Gastroenterology 15: 620, 1950. CrossrefMedlineGoogle Scholar7. GoodmanBaumoelFrankelMarcusWasserman JISLLJS: The diabetic neuropathies, 1953, Charles C Thomas, Springfield, Ill. Google Scholar8. GrossmanIvy MIAC: Effect of alloxan upon external secretion of the pancreas, Proc. Soc. Exper. Biol. and Med. 63: 62, 1946. CrossrefMedlineGoogle Scholar9. JonesCastleMulhollandBailey CMWBHBE: Pancreatic and hepatic activity in diabetes mellitus, Arch. Int. Med. 35: 315, 1925. CrossrefGoogle Scholar10. LandabureMonticelliWaismanGarcia PBALGNA: Diabetes y esteatorrea, Rev. Asoc. argent. dietol. 6: 107, 1948. Google Scholar11. Martin MM: Diabetic neuropathy; clinical study of 150 cases, Brain 76: 594, 1953. CrossrefMedlineGoogle Scholar12. Muri JW: Nocturnal diarrhea in diabetes, Acta med. Scandinav. 146: 143, 1953. CrossrefMedlineGoogle Scholar13. PollardMillerBrewer HMLWA: Clinical study of secretin test, Am. J. Digest Dis. 9: 68, 1942. CrossrefGoogle Scholar14. PollardMillerBrewer HMLWA: External secretion of pancreas and diabetes (study of secretin test), Am. J. Digest. Dis. 10: 20, 1943. CrossrefGoogle Scholar15. Rudy A: An unusual case of deficiency disease in a patient with diabetes mellitus, Endocrinology 27: 206, 1940. CrossrefGoogle Scholar16. RudyEpstein ASH: Diabetic neuropathy, review of 100 cases, J. Clin. Endocrinol. 5: 92, 1945. CrossrefGoogle Scholar17. Rundles RW: Diabetic neuropathy, general review with report of 125 cases, Medicine 24: 111, 1945. CrossrefGoogle Scholar18. Rundles RW: Diabetic neuropathy, Bull. New York Acad. Med. 26: 598, 1950. MedlineGoogle Scholar19. SheridanBaily EPCC: Nocturnal diarrhea in diabetes, J. A. M. A. 130: 632, 1946. CrossrefMedlineGoogle Scholar20. SwartsStine JMLA: Visceral neuropathy complicating diabetes, Am. J. Med. 5: 610, 1948. CrossrefMedlineGoogle Scholar21. Van de KamerTen Bokkel HuininkWeyers JHHHA: Rapid method for the determination of fat in feces, J. Biol. Chem. 177: 347, 1949. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: *Received for publication September 9, 1957.From the Department of Medicine, University of Kansas Medical Center, Kansas City, Kansas, and the Medical Service and Radioisotope Laboratory, Veterans Administration Hospital, Kansas City, Missouri.Requests for reprints should be addressed to Arthur P. Klotz, M.D., Associate Professor of Medicine, Section of Gastroenterology, University of Kansas Medical Center, Kansas City 3, Kansas. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byExocrine Pancreatic Insufficiency in Diabetic Patients: Prevalence, Mechanisms, and TreatmentThe Gastrointestinal Hormones Secretin and CholecystokininChronic pancreatitis in African diabeticsGastrointestinal Manifestations of DiabetesThe Exocrine Pancreas in Diabetes MellitusJOSEPH B. VACCA, M.D., F.A.C.P., WILBERT J. HENKE, M.D., WILLIAM A. KNIGHT JR., M.D., F.A.C.P.Diabetic steatorrhea: A distinct entityExternal Pancreatic Secretion in Diabetes MellitusWOO YOON CHEY, M.D., HARRY SHAY, M.D., F.A.C.P., CHARLES R. SHUMAN, M.D., F.A.C.P.Malabsorption and the Diarrhea of Diabetes MellitusOn the Pathogenesis of Diabetic SteatorrheaS. M. SUMI, M.D., J. M. FINLAY, M.D., F.R.C.P. (C), F.A.C.P.The Gastrointestinal Hormones, Secretin and Cholecystokinin-PancreozyminJ. ERIK JORPES, M.D., VIKTOR MUTT, M.D.The Use of Radioactive Tagged Lipids in the Differential Diagnosis of JaundiceDIABETES AND STEATORRHEA IN PRIMARY CARCINOMA OF THE PANCREAS*PETER M. MASLEY, M.D., CHARLES A. BONANNO, M.D., WILLIAM J. GRACE, M.D., F.A.C.P. 1 October 1958Volume 49, Issue 4Page: 820-828KeywordsDiarrheaExcretionFatsHospital medicineMedical servicesNeuropathyPancreasPancreatitisResearch laboratoriesSecretin ePublished: 1 December 2008 Issue Published: 1 October 1958 PDF downloadLoading ...