tbuckley/cabot-search huggingface dataset:
Hyperferritinaemia in the absence of iron overload
Authors: J D Arnold, A D Mumford, J O Lindsay, U Hegde, M Hagan, J R Hawkins
Journal: Gut (1997)

Background —Serum ferritin is normally a marker of iron overload. Ferritin genes are sited at chromosomes 19 and 11. Regulation of ferritin synthesis involves an interaction between an iron regulatory protein (IRP) and part of the ferritin mRNA designated the iron regulatory element (IRE). A disorder of ferritin synthesis resulting in hyperferritinaemia in the absence of iron overload has been described recently. Patients and methods —Hyperferriti- naemia in the absence of iron overload was detected in a patient who was investigated for possible haemochromatosis. Serum iron, transferrin saturation, and ferritin concentration were studied in 11 members of this patient’s family from three generations. Eight members had DNA samples analysed by direct cycle sequencing of the 5′ untranslated region of the L ferritin gene. Results —Six of the family members studied had serum ferritin concentrations greater than 900 μg/l. However, serum iron and transferrin saturation were normal in these subjects who all had evidence of cataracts. Three affected family members who had genetic studies of the L ferritin gene on chromosome 19 had an A to G point mutation which was not found in unaffected members. Conclusions —There was complete concordance between a mutated IRE, cataracts, and hyperferritinaemia in three generations of this family. This family study confirms the finding that hereditary hyperferritinaemia in the absence of iron overload is an autosomal dominant inherited disorder.
DIFFERENTIAL EFFECTS OF DABIGATRAN ETEXILATE AND TICAGRELOR ON BLEEDING AS ASSESSED BY WASHED BLOOD AND SHED BLOOD TESTS IN HEALTHY SUBJECTS
Authors: Joanne van Ryn, Thomas Giessmann, Ghazaleh Gouya, Michael Wolzt, Johanna Schurer, Maximilian Lobmeyer, Martina Brueckmann
Journal: Journal of the American College of Cardiology (2013)
Correction: UCLA Conference
Authors: JAMES R. KLINENBERG
Journal: Annals of Internal Medicine (1973)

Comments and Corrections1 May 1973Correction: UCLA ConferenceJAMES R. KLINENBERG, M.D.JAMES R. KLINENBERG, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-78-5-795_2 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: In the January 1973 issue, in the UCLA Conference, "Urate Deposition Disease," which I moderated, there is a serious typographical error on page 110, in the question of Dr. Harvey C. Gonick. The end of that paragraph should read, "Regarding the model of gouty nephropathy, I believe it may relate more to the kind of disease you see after treatment of a myeloproliferative disorder, when tubular blockade of uric acid occurs, rather than the very subtle disorder that occurs over many, many years of exposure with only mild elevations in serum urate."... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: JAMES R. KLINENBERG, M.D.Affiliations: Department of Medicine UCLA School of Medicine Los Angeles, California PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 May 1973Volume 78, Issue 5Page: 795-795KeywordsMyeloproliferative disordersUric acid ePublished: 1 December 2008 Issue Published: 1 May 1973 PDF downloadLoading ...
UNILATERAL HYPERHIDROSIS AND EROSION OF TEETH FOLLOWING PAROTID ABSCESS
Authors: WARREN T. VAUGHAN
Journal: JAMA (1925)

Excessive localized sweating has long been recognized, the first detailed observation being that of Nitzelnadel, who in 1867 reported a case of exophthalmic goiter in which the left side of the face alone was found to perspire freely. Raymond, in 1888, presented a classification of hyperhidrosis of the face which has been accepted by New and Bozer as recently as 1922.  Facial ephidrosis may accompany disease of the central nervous system (hemiplegia, general paralysis, glioma, tabes dorsalis or spinal cord injury); it may accompany structural or functional pathologic changes in the cervical symphathetics (round cell infiltration of ganglions or disease of the superior mediastinum or cervical region). It has occasionally been reported in general debilitating disease (diabetes mellitus or obscure abdominal conditions). 1   Adamkiewicz 2 found that fibers controlling the secretion of sweat are present in the facial nerve. Faradic stimulation of this nerve in healthy persons caused profuse secretion
Investigations on the structure of solid lipid nanoparticles (SLN) and oil-loaded solid lipid nanoparticles by photon correlation spectroscopy, field-flow fractionation and transmission electron microscopy
Authors: Katja Jores, Wolfgang Mehnert, Markus Drechsler, Heike Bunjes, Christoph Johann, Karsten Mäder
Journal: Journal of Controlled Release (2004)
1111-223 Left ventricular reverse remodeling predicted rehospitalization for heart failure after cardiac resynchronization therapy
Authors: Cheuk-Man Yu, Jeffrey Wing-Hong Fung, Qing Zhang, Chi-Kin Chan, Shun-Ling Kong, Hong Lin, Yat-Sun Chan, Yan Zhang, Gabriel W.K Yip, Leo C.C Kum, Eugene B Wu, John E Sanderson
Journal: Journal of the American College of Cardiology (2004)
Is Choledochocele Innocent Bystander or Culprit? Reply to Kim et al.
Authors: T. Ohtsuka, M. Tanaka
Journal: Endoscopy (2002)

The most important finding in our study is the high amylase level in bile demonstrated in patients with choledochocele. It is well known that pancreaticobiliary malunion (PBM) is a risk factor for the development of carcinoma in the biliary tract, and carcinomas tend to occur where the bile containing amylase stagnates: i. e. common bile duct carcinoma in those with a choledochal cyst and gallbladder carcinoma where there is no cyst [1] [2]. Changes in biliary phospholipids as a result of reflux of pancreatic juice into the biliary tract via the PBM may be responsible for the malignant change [3]. Choledochocele often causes acute cholangitis and/or pancreatitis, which are considered to be due to bile stagnation in the choledochocele itself [4]. This is likely to be true because endoscopic sphincterotomy (ES) is usually effective in relieving symptoms [5] [6]. Although choledochocele is excluded from the category of PBM, all of our four patients examined showed a high amylase concentration in bile. From this point of view, if the carcinoma had an association with choledochocele, it would tend to occur in the choledochocele itself. As Kim et al. state, it is very difficult to determine the precise origin of carcinoma in some cases, but two patients, one described in the report of Ozawa et al. [7] and one in our series, were considered to have a carcinoma in a choledochocele. The description suggested by Kim et al., i. e. ”Carcinoma associated with choledochocele,“ sounds vague as to whether the carcinoma is primary or secondary. The analysis of bile in our study presents the possibility that carcinoma may develop secondarily in the choledochocele by the same mechanism as carcinogenesis in patients with PBM, and thus we gave our article the title ”Carcinoma arising in choledochocele.“ How are Kim et al. able to state that the choledochocele of their patient was secondary? Is this mere coincidence?
MISSED OPPORTUNITIES IN THE MANAGEMENT OF ST SEGMENT ELEVATION MYOCARDIAL INFARCTION IN THE ARAB MIDDLE EAST: PATIENTS AND PHYSICIANS IMPEDIMENTS
Authors: Mouaz H. Al-Mallah, Alawi A. Alsheikh-Ali, Wael Almahmeed, Kadhim Sulaiman, Jassim Al Suwaidi, Mustafa Ridha, Ahmed Al-Motarreb, Fahad Alenezi, Mohammad Zubaid
Journal: Journal of the American College of Cardiology (2010)
Association Between INK4a-ARF and p53 Mutations in Skin Carcinomas of Xeroderma Pigmentosum Patients
Authors: N. Soufir
Journal: JNCI Journal of the National Cancer Institute (2000)

The INK4a-ARF locus encodes two tumor suppressor proteins, p16(INK4a) and p14(ARF), that act through the Rb-CDK4 and p53 pathways, respectively. Data from murine models and sporadic human skin carcinomas implicate p16(INK4a) and p14(ARF) in the development of skin carcinomas. We examined the frequency of INK4a-ARF, p53, and CDK4 mutations in skin carcinomas from patients with xeroderma pigmentosum (XP), a rare autosomal disease that is associated with a defect in DNA repair and that predisposes patients to skin cancer.DNA from skin cancers of 28 unrelated XP patients was screened for mutations in p53, INK4a-ARF, and CDK4 coding exons by single-strand conformation polymorphism analysis and automated sequencing. Data were evaluated with the use of the exact unconditional test derived from Fisher's test. All statistical tests were two-sided.Eight of 28 XP-associated tumors had mutations in the INK4a-ARF locus. Three XP-associated tumors had multiple mutations at this locus. In all, 13 mutations in the INK4a-ARF locus were detected in XP-associated tumors, of which seven (54%) were signature UV radiation-induced mutations, i.e., tandem CC : GG-->TT : AA transitions. p53 mutations, mostly of the type induced by UV radiation, were present in 12 tumors (43%). Statistically significant positive associations were found between the frequency of mutations in p53 and in p16(INK4a) (P =.008) and between the frequency of mutations in p53 and in p14(ARF) (P<.001). No mutations were detected within the CDK4 gene.We have demonstrated for the first time the occurrence of UV radiation-induced mutations in INK4a-ARF in XP-associated skin carcinomas. The simultaneous inactivation of p53 and INK4a-ARF may be linked to the genetic instability caused by XP and could be advantageous for tumor progression.
Attitudes Toward Clinical Trials Among Patients and the Public
Authors: Barrie R. Cassileth
Journal: JAMA (1982)

Attitudes toward clinical research, the focus of recent and damaging media attention, were assessed through questionnaires completed anonymously by 104 patients with cancer, 84 cardiology patients, and 107 members of the general public. Responses differed neither by subgroup nor by demographic variables. Data are therefore reported on the total population of 295 subjects. Most respondents (71%) believed that patients should serve as research subjects. In support of this belief, the majority cited potential benefit ot others and the opportunity to increase scientific knowledge, but a different bias emerged when they were asked about their own potential participation. This study shows that diverse respondents view clinical trials as important, ethical, and as a means of attaining superior clinical care. Major importance is attributed to making contributions to medical knowledge and to helping future patients. Contrasts are noted in patients' views of their own treatments v treatments of "'hypothetical others."Attitudes toward clinical trials, as assessed through questionnaires completed by 104 cancer patients, 84 cardiology patients, and a control group of 107 members of the general public, revealed no differences of opinion either by subgroup or by demographic variables. Most respondents believed patients should serve as research subjects regardless of medical status, and that participation helps future patients and increases medical knowledge while providing superior care in an ethical setting. However, responses concerning potential personal participation revealed more self concern and less altruism.
Some Aetiological Problems in Mental Deficiency
Authors: J. M. Berg, B. H. Kirman
Journal: BMJ (1959)

Though many classifications of the subject exist, mental deficiency may conveniently be considered in two groups ?minor (high-grade) and severe (low-grade) mental defect. This simple division corresponds, though not exactly, with that proposed by Lewis (1933) and restated by Bourne (1957). Lewis regarded some cases of mental defect as pathological and some as subcultural. The subcultural cases coincide mainly with those of minor degrees of intellectual defect. This thesis, as presented by Penrose (1954a), assumes that some defectives are such because of pathological lesions, and others because of biological variation. In fact, if the biological variation is of such a degree as to produce seriously impaired intelligence, which does not permit the individual to cope with his environment, then the condition must be regarded as pathological. Similarly, it seems reasonable to suppose that many of the pathological lesions responsible for cases of mental defect are one of the means whereby biological variation operates. There is no agreed definition of what constitutes high-grade, or minor, mental defect. Definitions based on intelligence quotient are of little value, as the Scottish Council for Research in Education (1949) showed that 3% of the population score less than an ?.Q. of 70 on a standard test, equivalent to one and a half millions in a population of fifty millions. Definitions based on legal recognition or ascertainment as mental defectives are of even less value, as O'Connor and Tizard (1956) have shown that the average I.Q. of the feeble-minded admitted to mental deficiency institutions is in the region of 70. It seems clear that psychological, educational, and social factors operate in a much more direct manner in producing the problem of minor mental defect. None the less, it should not be assumed that gross pathological lesions are encountered only in idiots and imbeciles and that they are not responsible for numerous cases of minor mental defect. In fact, all the diseases and factors operating in the production of gross mental deficiency may operate in a  diluted  form to produce minor degrees of mental defect. We will quote some examples of this process before going on to the main theme.
THE QUALITY OF DRUGSOLD TO DITOSING PHYSICIANS
Authors: W.. PUCKNER
Journal: JAMA (1913)

Last year in reporting the work of the Chemical Laboratory of the American Medical Association bearing on the quality of unofficial and little-used drugs I took the ground that drugs which were widely used and which were sold under competition were likely to be of good quality and that, on the other hand, little-used drugs were unreliable and likely to be of poor grade. While this contention, if correct, would indicate that standard drugs would be of good quality, no matter where purchased, it has been said repeatedly and insistently in pharmaceutical circles1that the drugs sold by physicians' supply houses are uniformly of poor quality. In general those who made these charges gave no specific proof of their assertions, and since pharmacists suffer financially through the dispensing of medicines by physicians these charges did not appear particularly convincing. That the charge that physicians dispense poor drugs was dictated largely
THE IDENTITY OF T. RHODESIENSE WITH THE TRYPANOSOME OF THE SAME APPEARANCE FOUND IN GAME
Authors: W. Yorke, B. Blacklock
Journal: BMJ (1914)

defaecationi, and dyspareuniia.From being a bright girl she became peevish and despondent, she slept badly, her appetite failed, and she lost nearly 2 st. in weight.When she was sent to me I found the left side of the cervix split up to the vaginal roof, and a tense tender scar stretching from there across the left vaginal fornix.About this scar were fixed the uterus and the left appendages, and the whole mass was intensely tender.I operated on her,_ repairing the torn cervix, lividing the vaginal scar freely, and stitching the transverse inicision across in the vertical direction, then opening the abdomen, freeing adhesions, removing the left appendages, and fixing the uterus to the anterior abdominal wall.She recovered well, and soon wenit to a convalescent home.Some weeks later her doctor again sent her to see me.She was still sleeping badly, anid very easilygot tired and worried.I found the pelvic organs in a very satisfactory condition, and was able to assure her that she ought soon to get ridl of her neuroses.A course of Inux vomica and bromide, continued for some weeks, helped towards this goal.Six months after her operation I again saw her, and hardly recognized her.She was fatter, brighter, and younger looking, was able to do her work with pleasure, and the pelvic symptoms had all gone.
Reversible Gynecomastia Associated With Sulindac Therapy
Authors: Anoop Kapoor
Journal: JAMA (1983)

<h3>To the Editor.—</h3> Sulindac is a nonsteroidal anti-inflammatory agent used commonly in the treatment of rheumatoid arthritis. The side effects, estimated to be about 25%,<sup>1</sup>usually involve the gastrointestinal system and CNS. We describe a patient who experienced gynecomastia after sulindac therapy, a previously unreported complication of this drug. <h3>Report of a Case.—</h3> A 63-year-old man had a condition diagnosed as rheumatoid arthritis. He had morning stiffness and progressive symmetrical polyarthritis of his shoulders, wrists, hands, knees, and ankles. The complete blood cell (CBC) count was normal, sedimentation rate was 46 mm/hr, rheumatoid factor titer was 1:1,725, antinuclear antibody was 1:80, and roentgenograms of both hands were consistent with the diagnosis. He had a poor response to aspirin and, while he was receiving aurothioglucose, an exfoliative dermatitis developed. Hence, he started receiving sulindac, 200 mg twice daily. After four months, he noticed occasionally painful left breast enlargement. There was
Endocarditis: A Multidisciplinary Approach to Modern Treatment
Authors: Mark J. DiNubile
Journal: Annals of Internal Medicine (2000)

Medical Writings: Book Notes1 August 2000Endocarditis: A Multidisciplinary Approach to Modern TreatmentMark J. DiNubile, MDMark J. DiNubile, MDCooper Health System/Robert Wood Johnson Medical School, Camden, New Jersey. (DiNubile)Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-133-3-200008010-00025 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail Vlessis AA, Bolling SF, eds. 409 pages. Armonk, NY: Futura; 1999. $98.00. ISBN 0879934336. Order phone 800-877-8761.Field of medicine: Cardiovascular medicine and infectious diseases.Format: Hardcover book.Audience: Physicians with established knowledge about endocarditis, such as subspecialists in infectious diseases, cardiology, and cardiothoracic surgery. Neurologists, pathologists, microbiologists, and epidemiologists will find selected chapters useful.Purpose: To provide practicing clinicians with a comprehensive update on diagnosis, management, and treatment of endocarditis.Content: The book is divided into four content areas: scientific foundation, diagnosis, management, and special considerations. Individual chapters cover the pathophysiology and changing epidemiology of endocarditis; intracardiac and extracardiac ... Author, Article, and Disclosure InformationAffiliations: Cooper Health System/Robert Wood Johnson Medical School, Camden, New Jersey. (DiNubile) PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 August 2000Volume 133, Issue 3Page: 244KeywordsCardiology and cardiovascular diseasesCardiothoracic surgeryEndocarditisEpidemiologyInfectious diseasesPathologistsPatientsSoftware toolsSub-specialty careSurgeons ePublished: 15 August 2000 Issue Published: 1 August 2000 Copyright & PermissionsCopyright © 2000 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Relationship between Number of Medical Conditions and Quality of Care
Authors: Takahiro Higashi, Neil S. Wenger, John L. Adams, Constance Fung, Martin Roland, Elizabeth A. McGlynn, David Reeves, Steven M. Asch, Eve A. Kerr, Paul G. Shekelle
Journal: New England Journal of Medicine (2007)

There is emerging concern that the methods used to measure the quality of care unfairly penalize providers caring for patients with multiple chronic conditions. We therefore sought to study the relationship between the quality of care and the number of medical conditions a patient has.
Testing for HIV Infection at Home
Authors: Ronald Bayer, Jeff Stryker, Mark D. Smith
Journal: New England Journal of Medicine (1995)

The Food and Drug Administration (FDA) in the United States is now considering whether to license diagnostic kits that would make possible testing and counseling for human immunodeficiency virus (HIV) infection in the privacy of a person's own home. The proposed kit has engendered a sharp controversy. Former Surgeon General C. Everett Koop has described such a test kit as the "single most important weapon we can employ in the fight against AIDS."1 Opponents warn that the prospect of catastrophic effects far outweighs the intended advantages.2 The proposed over-the-counter kit would radically change the role of health professionals at critical . . .
Ontological fallacy in heart failure
Authors: H. F McIntyre
Journal: BMJ (2009)

Echocardiography1 has resulted in the belief that heart failure and reduced ejection fraction are synonymous. Recently, however, the utility of ejection fraction in diagnosis has been undermined by epidemiological studies, which have shown that ejection fraction is continuously distributed in populations with heart failure,2 and that survival is the same irrespective of whether there is heart failure with normal ejection fraction (HFNEF) or with …
Diagnostic Decision
Authors: GAVIN HART
Journal: Annals of Internal Medicine (1986)

Predictive value calculations were used to derive diagnostic guidelines for syphilis. Specificity of the VDRL (Venereal Disease Research Laboratory) and treponemal tests is high in healthy persons but less in elderly and ill persons. Sensitivity of the VDRL test is high in secondary and early latent syphilis but reduced in primary and late syphilis or in cerebrospinal fluid evaluations. Primary syphilis should be diagnosed by darkfield microscopy, with VDRL confirmation for atypical lesions. Screening of asymptomatic persons with the VDRL test, followed by treponemal test confirmation on positive sera, is recommended for all pregnant women, contacts of persons with infectious syphilis, and other high-risk groups. Quantitative VDRL assessment at 3, 6, and 12 months after treatment should be used to assess the adequacy of treatment for both late latent and early syphilis. Cerebrospinal fluid VDRL assessment and cell count should be restricted to seropositive persons with a high risk of neurosyphilis.
General Internal Medicine, Family Practice or Something Better?
Authors: Gerald T. Perkoff
Journal: New England Journal of Medicine (1978)

The field of internal medicine developed mainly as a special area of expertise to serve patients with complex diagnostic problems, usually referred by general practitioners who needed consultative assistance with such patients. From such simple beginnings, the specialty has gradually changed into a highly sub-specialized, increasingly technologic, procedure-oriented field of patient care and research. As such, it has a great deal to offer seriously ill patients. In the process, however, internists have become much less useful and less used in a general consultative role. The general internist who practices mainly in the hospital still has a major role as a . . .