tbuckley/cabot-search huggingface dataset:
Lung and respiratory muscle function in limb girdle muscular dystrophy.
Authors: J P Stubgen, G J Ras, C M Schultz, G Crowther
Journal: Thorax (1994)

BACKGROUND--Pulmonary involvement is frequently observed in patients with limb girdle muscular dystrophy and occurs early in the disease. The aim of this study was to establish the prevalence of pulmonary dysfunction; the type of dysfunction; and any correlation between patient age, disease duration, or limb weakness and lung or respiratory muscle dysfunction. METHODS--Twenty patients with strictly delineated limb girdle muscular dystrophy and 20 healthy controls were evaluated. Full inspiration chest radiographs were obtained. Standard lung and respiratory muscle function tests were performed and the data were statistically analysed. RESULTS--The mean age of the patients was 40.6 years, the mean disease duration was 18.9 years, and the mean average muscle score (a numerical expression of limb weakness) was 5.73 out of 10. Chest radiography showed unilateral paresis of the diaphragm in three patients. Increased residual volumes, with either increased or decreased total lung capacity, correlated inversely with disease duration. Respiratory muscle weakness was common but mild. Expiratory muscle function was more impaired than inspiratory muscle function and correlated positively with expiratory reserve volume. CONCLUSIONS--Respiratory muscle strength is commonly impaired in limb girdle muscle dystrophy. A dissociation of the limb and mild respiratory muscle involvement is observed; wheelchair restriction does not predict worsening of pulmonary function, and patient age, disease duration, or degree of limb weakness do not predict pulmonary morbidity. The diaphragm is not disproportionately affected by the dystrophic process compared with limb muscles.
Dramatic increase in lymph node dendritic cell number during infection by the mouse mammary tumor virus occurs by a CD62L-dependent blood-borne DC recruitment
Authors: Pilar Martı́n, Sara Ruiz Ruiz, Gloria Martı́nez del Hoyo, Fabienne Anjuère, Héctor Hernández Vargas, Marı́a López-Bravo, Carlos Ardavı́n
Journal: Blood (2002)
Endothelial adhesion molecules in glomerular lesions: Association with their severity and diversity in lupus models
Authors: Kimihiko Nakatani, Hiroshi Fujii, Hitoshi Hasegawa, Miho Terada, Norimasa Arita, Mitsuko R. Ito, Masao Ono, Satoru Takahashi, Kan Saiga, Shuhei Yoshimoto, Masayuki Iwano, Hideo Shiiki, Yoshihiko Saito, Masato Nose
Journal: Kidney International (2004)
Catholic Medical School Dilemmas
Authors: Gerald A. Kerrigan
Journal: JAMA (1969)

<h3>To the Editor:—</h3> The Journalarticle entitled, "Catholic Medical School Dilemmas" included the Marquette School of Medicine (<b>207</b>: 28, 1969). On Sept 30, 1967, the Articles of Association of the Marquette University School of Medicine were altered so that the medical school became a corporation legally distinct from the corporation of Marquette University. At that time the name of the medical school was legally changed from Marquette University School of Medicine to Marquette School of Medicine, Inc. Provisions of the articles of incorporation whereby the 15-member board of directors of the medical school included five members appointed by the President of Marquette University were eliminated. New articles of incorporation were adopted whereby all members of the board of directors were elected by the board. The new corporation is an autonomous, self-perpetuating corporation. The new medical school board is empowered to set all standards in the medical school and to confer degrees.
TCT-684 OCT As A Rule Out Test For Thromboembolism In Pulmonary Arterial Hypertension: Insights From A OCT Study Of The Pulmonary Vascular Tree.
Authors: Christopher D. Loder, Chris P. Denton, Jamanda Haddock, Thomas Wagner, David Dobaro, Clive Handler, Benjamin E. Schreiber, John G. Coghlan
Journal: Journal of the American College of Cardiology (2013)
Cutaneous zygomycosis caused by <i>Cunninghamella bertholletiae</i> in a patient with chronic myelogenous leukemia in blast crisis
Authors: Kenji Motohashi, Satomi Ito, Maki Hagihara, Atsuo Maruta, Yoshiaki Ishigatsubo, Heiwa Kanamori
Journal: American Journal of Hematology (2008)

Cutaneous zygomycosis in immunocompromised patients is often reported, and this lesion is thought to be a risk of life-threatening infection by systemic dissemination [1].We report here a patient who developed a cutaneous infection by Cunninghamella bertholletiae, which is an extremely rare pathogen in zygomycosis [2].A 60-year-old female was admitted with dyspnea and palpitation in January 2007.Physical examination revealed no organomegaly.Her peripheral blood examination showed a white blood cell count of 15.1 3 10 9 /l with 51.0% blasts, a hemoglobin concentration of 8.4 g/dl, and a platelet count of 126 3 10 9 /l.The results of serum biochemical and serological tests indicated increased serum levels of lactate dehydrogenase and vitamin B 12 .Bone marrow aspirate Image 1. (A) Photograph of skin lesion with central necrosis and outer halo.(B) Histopathologic examination indicated nonseptate hyphae in the vessel (periodic acid-Schiff staining, original magnification 3600).(C) Culture of the specimen on Sabouraud dextrose agar showed cotton-like colonies.(D) Lactophenol cotton blue staining (3600) showed sporangiophores.
Abortion and maternal deaths
Authors: D. Munday
Journal: BMJ (1976)

rather than the failure of the health authority or the district management team.The superin- tendent who speaks out on behalf of his hospital runs the risk of incurring the dis- pleasure and pique of authorities.If the post of superintendent is as incompatible with the new system and as redundant as is widely claimed it would appear reason- able, logical, and fair to give it an appropriate burial on a national basis with guidance from the DHSS on the recompense of those who, through no fault of their own, were appointed to such posts and now find themselves in an uncertain and embarrassing position.
Children will suffer most as climate change increases in coming decades, say scientists
Authors: R. McKie
Journal: BMJ (2013)

Climate scientists have issued their grimmest warning yet on the dangers posed by global warming. In a report being debated in Stockholm this week by politicians from around the world, researchers have emphasised that fossil fuel consumption and deforestation have already triggered a rise in global temperatures of almost 1°C since the dawn of the industrial revolution.1

The fifth assessment report on the physical science of climate change by the Intergovernmental Panel on Climate Change (IPCC) adds that this increase could double to more than 2°C in the next few decades. Extreme weather events such as heatwaves …
<i>Gut</i> in 1998—Looking back, looking forward
Authors: MICHAEL J G FARTHING
Journal: Gut (1998)

1997 was a good year for Gut . We have continued our editorial policy to increase the number of sections in the journal. In addition to commentaries, we have introduced a new section, Science Alert, which aims to highlight important scientific advances relevant to gastroenterology. We are screening the major basic science journals for papers which we believe will be of interest to Gut ’s readership and we have asked experts to summarise the work and explain its importance to gastroenterology.

We were keen to define the profile of papers published in Gut as concern had been raised that the journal was becoming excessively orientated towards basic science and perhaps have less appeal to practicing clinicians. Gut certainly has no such policy. For the British Society of Gastroenterology Diamond Jubilee supplement, Tom MacDonald’s analysis showed that the most cited papers in …
Contrasting acute graft-versus-host disease effects of Tim-3/galectin-9 pathway blockade dependent upon the presence of donor regulatory T cells
Authors: Rachelle G. Veenstra, Patricia A. Taylor, Qing Zhou, Angela Panoskaltsis-Mortari, Mitsuomi Hirashima, Ryan Flynn, Derek Liu, Ana C. Anderson, Terry B. Strom, Vijay K. Kuchroo, Bruce R. Blazar
Journal: Blood (2012)
Insulin-like Growth Factor II and the Riddle of Tumor-Induced Hypoglycemia
Authors: Lloyd Axelrod, David Ron
Journal: New England Journal of Medicine (1988)

Sometimes a problem in pathophysiology captures our imagination out of proportion to its frequency in clinical practice. The syndrome of tumor-induced hypoglycemia, in which hypoglycemia occurs in association with non-islet-cell tumors, is a case in point. In this syndrome, we encounter a dramatic clinical presentation of an uncommon group of tumors whose pathophysiology has until recently defied explanation. Often, it is the hypoglycemia that brings the patient to medical attention. Because the symptoms of neuroglycopenia, such as coma, seizures, or focal neurologic abnormalities, predominate over symptoms of adrenergic activation, the clinical findings resemble those of an insulinoma. The tumors most . . .
Risks of gene therapy should be weighed against lack of alternatives for many diseases
Authors: Robert E MacLaren, Robin R Ali, Adrian J Thrasher
Journal: BMJ (2005)

EDITOR—Kimmelman provided a comprehensive discussion about the risks and ethics of gene therapy.1 We certainly cannot predict the future, but the risks should be weighed against the complete lack of alternative options for many of the diseases discussed.

The two cases of …
A piece of my mind. Partner in crime
Authors: L. Shewell
Journal: JAMA (1989)

As I stand in the doorway of your hospital room, arms full of admission assessment forms, light from the high window striates your face and shines on the metal side rails of your bed. Your face is sunken, all eyes; your chest heaves in spasmodic jerks. Heart disease, dementia, old age. I can't believe you're the same lady who used to cheat my grandmother at cards. I never understood why you cheated. Gran was so distracted by my failing grandfather, you could've beaten her fair and square. I remember the day the two of you were playing canasta on the back porch while Grandpa slouched in his wheelchair nearby. I was in the yard, squatting near the porch stairs, waiting for Gran to play her hand so I could crawl under the porch and drag out the garden hose to wet down my sandbox, a practice Gran forbade. The time
Cross-site comparison of gene expression data reveals high similarity.
Authors: Tzu-Ming Chu, Shibing Deng, Russ Wolfinger, Richard S Paules, Hisham K Hamadeh
Journal: Environmental Health Perspectives (2004)

Consistency and coherence of gene expression data across multiple sites depends on several factors such as platform (oligo, cDNA, etc.), environmental conditions at each laboratory, and data quality. The Hepatotoxicity Working Group of the International Life Sciences Institute Health and Environmental Sciences Institute consortium on the application of genomics to mechanism-based risk assessment is investigating these factors by comparing high-density gene expression data sets generated on two sets of RNA from methapyrilene (MP) experiments conducted at Abbott Laboratories and Boehringer-Ingelheim Pharmaceuticals, Inc. using a single platform (Affymetrix Rat Genome U34A GeneChip) at seven different sites. This article focuses on the evaluation of data quality and statistical models that facilitate the comparison of such data sets at the probe level. We present methods for exploring and quantitatively assessing differences in the data, with the principal goal being the generation of lists of site-insensitive genes responsive to low and high doses of MP. A combination of numerical and graphical techniques reveals important patterns and partitions of variability in the data, including the magnitude of the site effects. Although the site effects are significantly large in the analysis results, they appear to be primarily additive and therefore can be adjusted in the statistical calculations in a way that does not bias conclusions regarding treatment differences.
Methyldopa-Induced Hypertension
Authors: Frederic B. Westervelt
Journal: JAMA (1974)

<h3>To the Editor.—</h3> Hypertension reaction during treatment with methyldopa (Aldomet) given together with trifluoperazine (Stelazine) is paradoxical. We were unable to find an account of this occurrence in the literature. A case report and discussion to follow are concerned with a possible interaction between methyldopa and trifluoperazine. <h3>Report of a Case.—</h3> In November 1968, a 23-year-old woman was found to have systemic lupus erythematosus with diffuse proliferative glomerulonephritis and nephrotic syndrome. Therapy with 15 mg of prednisone every six hours had not changed her proteinuria (10 gm daily) or renal failure (plasma creatinine, 2.1 mg/100 ml; creatinine clearance, 32 ml/min), although azotemia had increased (blood urea nitrogen [BUN] value, from 60 to 120 mg/100 ml) by mid-December; blood pressure was 120/100 mm Hg. She then became psychotic and was given up to 15 mg of trifluoperazine (Stelazine) daily, and up to 120 mg of prednisone daily. By mid-January 1969, the
Perfluorinated Compounds and Immunotoxicity in Children
Authors: Geary W. Olsen
Journal: JAMA (2012)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The Treatment of Nephrosis
Authors: Krishna M. Saxena, John D. Crawford
Journal: New England Journal of Medicine (1965)

THIS review is based upon our practices and an evaluation of their results over a twenty-year experience in the treatment of children with nephrosis. Limitations of space make it necessary to omit many considerations of interest, but it is hoped that those included are the more important ones to practitioners handling the occasional case of this relatively uncommon disorder.It is necessary at the outset to define nephrosis since the term has a variety of connotations. In the context of the following discussion nephrosis will be taken to mean the usually idiopathic, acquired disorder occurring primarily in infants and children, . . .
Therapeutic retraction of the foreskin in childhood.
Authors: G G Cooper, G J Thomson, P A Raine
Journal: BMJ (1983)

A retrospective study was conducted of 91 boys who had had a non-retractable but non-fibrosed prepuce treated by retraction under general anaesthesia. Of the 79 boys who had had symptoms, 67 (85%) obtained relief. Twelve of the 91 patients were later circumcised because of continuing problems. Retraction of the foreskin alone is a simple and effective alternative to circumcision in managing most boys with a symptomatic, non-retractable prepuce.
Purification and characterization of a bile acid ?-glucosidase from human liver microsomes
Authors: H HEINEMANN
Journal: Hepatology (1995)

α-Glucosidase inhibitors—e.g., 1-deoxynojirimycin (DNM)—interfere with HIV infectivity in CD4+cell cultures but have proven unsuccessful in clinical trials.In vitro,several HIV Env properties, including the cleavage of the Env precursor gp160, the immunoreactivity of the third variable domain (V3) of Env, the binding to the CD4 receptor, and the induction of the membrane fusion between the virus and the host cell, have been reported to be altered by such inhibitors. We have studied these properties for Env expressed via a recombinant vaccinia virus in two Chinese hamster ovary cell lines, an α-glucosidase I-deficient cell line and its parental cell line, treated with DNM under conditions that have been reported to alter Env properties. The glycosylation of Env, but not the quantity produced, varied in accordance with the experimental conditions. However, irrespective of these conditions, Env cleavage, V3 immunoreactivity, CD4 binding, membrane expression, and ability to induce syncytium formation were similar. Thus, neither the α-glucosidase I deficiency nor DNM treatment had a significant effect on the properties of Env produced here. Cellular mechanisms that may allow the normal expression of Env are discussed and may offer an explanation for the many discrepant results obtained to date on the effects of DNM on HIV Env.
Medical Bibliographic Searches
Authors: BRUCE R. ELLINOY
Journal: Annals of Internal Medicine (1974)

Comments1 July 1974Medical Bibliographic SearchesBRUCE R. ELLINOY, PHARM.D.BRUCE R. ELLINOY, PHARM.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-81-1-127 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: In the December 1973 issue (Ann Intern Med79:917-924, 1973), Mr. Beatty discussed usage of medical library resources. I wish to emphasize some precautionary observations on using the two major National Library of Medicine indexing services,Index Medicusand the Medline/Compfile Computer System (MCCS). Both systems have their inherent problems. Ideally, the MCCS should result in a more comprehensive retrieval of articles. However, whereas the individual's usage ofIndex Medicusis dependent onhisknowledge of his topic, the MCCS, when programmed by the research analyst, is dependent on theanalyst'sknowledge of the submitter's topic and... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Clinical Pharmacy Service Los Angeles County USC Medical Center 1200 N. State St., Rm. 6002 Los Angeles, California 90033 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 July 1974Volume 81, Issue 1Page: 127-127KeywordsComputersComputing systemsLibrariesResearch and reporting methods Issue Published: 1 July 1974 PDF DownloadLoading ...
Clinical variants of the preprotuberant stage of dermatofibrosarcoma protuberans
Authors: L. Martin, F. Piette, P. Blanc, L. Mortier, M-F. Avril, M.M. Delaunay, B. Dreno, F. Granel, F. Mantoux, F. Aubin, B. Sassolas, H. Adamski, S. Dalac, C. Pauwels, A. Dompmartin, C. Lok, E. Esteve, B. Guillot
Journal: British Journal of Dermatology (2005)

Some cases of dermatofibrosarcoma protuberans (DFSP) do not protrude above the skin.To assess the prevalence of these DFSPs and further to describe their presentation and course.One hundred and forty-three patients were retrospectively collected. They were asked to complete a standardized questionnaire indicating the history and appearance of the DFSP from the first skin changes identified to the time of diagnosis.Eighty-one DFSPs were described as protuberant ab initio, and 62 as initially nonprotuberant (npDFSP). The latter remained at this stage for a mean period of 7.6 years. Twenty-nine per cent of npDFSPs were 'morphoea-like', 19% were 'atrophoderma-like' and 42% were 'angioma-like'. Age at diagnosis was similar for both initial presentations. npDFSPs were most often misdiagnosed by physicians.Nearly half the patients first identified their early DFSP-related skin changes as patches. Both this frequency and the long duration at this preprotuberant stage should prompt dermatologists to consider the diagnosis of DFSP earlier, in order to make surgical treatment easier.
Interaction of blood lead and delta-aminolevulinic acid dehydratase genotype on markers of heme synthesis and sperm production in lead smelter workers.
Authors: B H Alexander, H Checkoway, P Costa-Mallen, E M Faustman, J S Woods, K T Kelsey, C van Netten, L G Costa
Journal: Environmental Health Perspectives (1998)

The gene that encodes gamma-aminolevulinic acid dehydratase (ALAD) has a polymorphism that may modify lead toxicokinetics and ultimately influence individual susceptibility to lead poisoning. To evaluate the effect of the ALAD polymorphism on lead-mediated outcomes, a cross-sectional study of male employees from a lead-zinc smelter compared associations between blood lead concentration and markers of heme synthesis and semen quality with respect to ALAD genotype. Male employees were recruited via postal questionnaire to donate blood and urine for analysis of blood lead, zinc protoporphyrin (ZPP), urinary coproporphyrin (CPU), and ALAD genotype, and semen samples for semen analysis. Of the 134 workers who had ALAD genotypes completed, 114 (85%) were ALAD1-1 (ALAD1) and 20 (15%) were ALAD1-2 (ALAD2). The mean blood lead concentrations for ALAD1 and ALAD2 were 23.1 and 28.4 microg/dl (p = 0.08), respectively. ZPP/heme ratios were higher in ALAD1 workers (68.6 vs. 57.8 micromol/ml; p = 0.14), and the slope of the blood lead ZPP linear relationship was greater for ALAD1 (2.83 vs. 1.50, p = 0.06). No linear relationship between CPU and blood lead concentration was observed for either ALAD1 or ALAD2. The associations of blood lead concentration with ZPP, CPU, sperm count, and sperm concentration were more evident in workers with the ALAD1 genotype and blood lead concentrations >/= 40 microg/dl. The ALAD genetic polymorphism appears to modify the association between blood lead concentration and ZPP. However, consistent modification of effects were not found for CPU, sperm count, or sperm concentration.
HYPERTENSION AND ARTERIOSCLEROSIS
Authors: B. Parsons-Smith
Journal: BMJ (1935)

A strict definition of the term " arteriosclerosis " is hardening of the arteries, the actual causation of which continues to be a matter of conjecture, in spite of numer- ous theories that have been advanced from time to time.The more important of these include: (1) inflammatory processes resulting from bacterial infections ; (2) degenerative changes secondary to long-continued mechanical strain on the vessels, old age, general wear and tear, etc.; and (3) disturbances in cholesterin metabolism, lipoid accumulations forming a striking feature in the early fibrotic and the later degenerative lesions characteristic of arteriosclerosis.A fVrther consideration relative to the aetiology of arteriosclerosis is the possible significance of hypertension, the occurrence of which, though by no means a constant, is frequently an outstanding, factor in the clinical picture.It is5 moreover, by no means decided as to which may be the cause and which the effect when hypertension and arteriosclerosis coexist, but the general consensus of opinion nowadays correlates hiypertension with primary changes in the vessels, contraction of the arterioles, hypertrophy of the muscular walls of the smaller vessels, and, at times, with arterio-capillary fibrosis in the kidneys. General SymptomsThe symptomatology of hypertensive arteriosclerosis may be described under two headings, as follows: