tbuckley/cabot-search huggingface dataset:
Adenovirus-Mediated VEGF <sub>121</sub> Gene Transfer Stimulates Angiogenesis in Normoperfused Skeletal Muscle and Preserves Tissue Perfusion After Induction of Ischemia
Authors: Luis Henrique W. Gowdak, Lioubov Poliakova, Xiaotong Wang, Imre Kovesdi, Kenneth W. Fishbein, Antonella Zacheo, Roberta Palumbo, Stefania Straino, Costanza Emanueli, Massimiliano Marrocco-Trischitta, Edward G. Lakatta, Piero Anversa, Richard G. S. Spencer, Mark Talan, Maurizio C. Capogrossi
Journal: Circulation (2000)

Administration of angiogenic factors stimulates neovascularization in ischemic tissues. However, there is no evidence that angiogenesis can be induced in normoperfused skeletal muscles. We tested the hypothesis that adenovirus-mediated intramuscular (IM) gene transfer of the 121-amino-acid form of vascular endothelial growth factor (AdCMV.VEGF(121)) could stimulate neovascularization in nonischemic skeletal muscle and consequently attenuate the hemodynamic deficit secondary to surgically induced ischemia.Rabbits and rats received IM injections of AdCMV.VEGF(121), AdCMV.Null, or saline in the thigh, 4 weeks (rabbits) or 2 weeks (rats) before femoral artery removal in the injected limb. In unoperated rats, at the site of injection of AdCMV.VEGF(121), we found 96% and 29% increases in length density of arterioles and capillaries, respectively. Increased tissue perfusion (TP) to the ischemic limb in the AdCMV.VEGF(121) group was documented, as early as day 1 after surgery, by improved blood flow to the ischemic gastrocnemius muscle measured by radioactive microspheres (AdCMV.VEGF(121)=5.69+/-0.40, AdCMV.Null=2.97+/-0.50, and saline=2.78+/-0.43 mL x min(-1) x 100 g(-1), P<0.001), more angiographically recognizable collateral vessels (angioscore) (AdCMV. VEGF(121)=50.58+/-1.48, AdCMV.Null=29.08+/-4.22, saline=11.83+/-1.90, P<0.0001), and improvement of the bioenergetic reserve of the gastrocnemius muscle as assessed by (31)P NMR spectroscopy. Follow-up studies showed that superior TP to the ischemic limb in the AdCMV.VEGF(121) group persisted until it was equalized by spontaneous collateral vessel development in untreated animals.IM administration of AdCMV.VEGF(121) stimulates angiogenesis in normoperfused skeletal muscles, and the newly formed vessels preserve TP after induction of ischemia.
Proliferation Marker Ki-67 in Early Breast Cancer
Authors: Ander Urruticoechea, Ian E. Smith, Mitch Dowsett
Journal: Journal of Clinical Oncology (2005)

Molecular markers have been extensively investigated with a view to providing early and accurate information on long-term outcome and prediction of response to treatment of early breast cancer. Proliferation is a key feature of the progression of tumors and is now widely estimated by the immunohistochemical assessment of the nuclear antigen Ki-67. The expression of Ki-67 correlates with other measurements of proliferation, including S-phase and bromodeoxyuridine uptake. High Ki-67 is a sign of poor prognosis associated with a good chance of clinical response to chemotherapy, but its independent significance is modest and does not merit measurements in most routine clinical scenarios. However, its application as a pharmacodynamic intermediate marker of the effectiveness of medical therapy holds great promise for rapid evaluation of new drugs.
New application of myocardial antimyosin scintigraphy: diagnosis of myocardial disease in polymyositis.
Authors: D Le Guludec, F Lhote, P Weinmann, I Royer, B Jarrousse, N Caillat-Vigneron, L Guillevin, J L Moretti
Journal: Annals of the Rheumatic Diseases (1993)

Heart disease is a rare but important complication of polymyositis. Diagnosis of myocardial disease is usually based on non-specific clinical, electrocardiographic, and echocardiographic data. This paper reports a case of polymyositis with myocardial disease diagnosed by myocardial imaging with radiolabelled antibody to myosin, a specific marker of the necrotic myocardial fibre.
Preventive Therapy With Isoniazid
Authors: Dixie E. Snider
Journal: JAMA (1986)

Daily administration of isoniazid for one year to persons infected with<i>Mycobacterium tuberculosis</i>is effective in considerably reducing the risk of disease. From a practical viewpoint, this approach to prevention is less than ideal because it results in considerable costs as health care providers monitor for possible hepatotoxic effects and because it is difficult to maintain compliance for 12 months. The efficacy and toxicity of isoniazid preventive therapy regimens of 12, 24, and 52 weeks' duration were recently assessed in a study conducted in Eastern Europe. We used data from this study to conduct a cost-effectiveness analysis of the three alternative regimens. The results indicate that over a wide range of assumptions, a regimen of 24 weeks' duration is more cost-effective than either the 12- or 52-week regimen. Using base case estimates, the cost per case prevented for the 24-week regimen was $7,112, compared with $16,024 for the 52-week regimen. Among a cohort of 1,000 persons treated, each additional case prevented by the 52-week regimen would cost $80,807. Thus, a shorter course of isoniazid preventive therapy is relatively cost-effective compared with current policy. (<i>JAMA</i>1986;255:1579-1583)
Human Adult Bone Marrow Mesenchymal Stem Cells Repair Experimental Conduction Block in Rat Cardiomyocyte Cultures
Authors: Saskia L.M.A. Beeres, Douwe E. Atsma, Arnoud van der Laarse, Daniël A. Pijnappels, John van Tuyn, Willem E. Fibbe, Antoine A.F. de Vries, Dirk L. Ypey, Ernst E. van der Wall, Martin J. Schalij
Journal: Journal of the American College of Cardiology (2005)
THE EFFECT OF COLD UPON MALARIA PARASITES IN THE MOSQUITO HOST
Authors: W. V. King
Journal: The Journal of Experimental Medicine (1917)

The experiments reported here have shown that the parasite of tertian malaria in the mosquito host is able to survive exposure to a temperature of 30° F. for a period of 2 days, 31° F. for 4 days, and a mean temperature of 46° F. for 17 days. In a smaller series of tests the sporonts of the estivo-autumnal parasite have shown a resistance to temperatures as low as 35° F. for 24 hours.
Regulation of pH in rat papillary tubule cells in primary culture.
Authors: J G Kleinman, S S Blumenthal, J H Wiessner, K L Reetz, D L Lewand, N S Mandel, G S Mandel, J C Garancis, E J Cragoe
Journal: Journal of Clinical Investigation (1987)

To investigate the mechanisms responsible for urinary acidification in the terminal nephron, primary cultures of cells isolated from the renal papilla were grown as monolayers in a defined medium. Morphologically, cultured cells were epithelial in type, and similar to collecting duct principal cells. Cell pH measured fluorometrically in monolayers grown on glass slides showed recovery from acid loads in Na+-free media. Recovery was inhibited by cyanide, oligomycin A, and N-ethylmaleimide. Cyanide and oligomycin inhibited recovery less in the presence than in the absence of glucose. When cells were first acid loaded in a Na+-free medium and then exposed to external Na+, pH recovery also took place. This recovery exhibited first-order dependence on Na+ concentration and was inhibited by 5-(N-ethyl-N-isopropyl)amiloride. These studies demonstrate that in culture, collecting duct principal cells possess at least two mechanisms for acid extrusion: a proton ATP-ase and an Na+-H+ exchanger. The former may be responsible for some component of the urinary acidification observed in the papillary collecting duct in vivo; the role of the latter in acid-base transport remains uncertain.
Nephropathy Associated With Methoxyflurane Anesthesia
Authors: Walter B. Crandell
Journal: JAMA (1968)

A toxic nephropathy associated with methoxyflurane anesthesia was observed in 17 patients. Marked diuresis was the predominant clinical characteristic. A test to distinguish between a primary renal disorder and an insufficiency of endogenous antidiuretic hormone was performed on six of the patients. Clear-cut impairment of renal function was demonstrated; gradual improvement, over a period of months, was noted on subsequent studies. Evidence of nephropathy associated with methoxyflurane anesthesia in 28 additional patients has been reported in the literature.
Evaluation of aortic regurgitation with digitally determined color doppler-imaged flow convergence acceleration: A quantitative study in sheep
Authors: Takahiro Shiota, Michael Jones, Izumi Yamada, Russell S. Heinrich, Masahiro Ishii, Brian Sinclair, Ajit P. Yoganathan, David J. Sahn
Journal: Journal of the American College of Cardiology (1996)
Bystander help in primary immune responses in vivo.
Authors: P E Jensen, J A Kapp
Journal: The Journal of Experimental Medicine (1986)

We evaluated the requirement for hapten-carrier linkage in the primary, T cell-dependent antibody response in vivo. Mice immunized with mixtures containing nonimmunogenic and immunogenic proteins developed antibody that was specific for determinants present on the nonimmunogenic carrier. Therefore, hapten-carrier linkage was not necessary for the generation of primary antibody responses. The magnitude of the bystander response was a function of the immunogenicity of the coimmunogen and the quantity of determinant-specific B cells available for activation. Interestingly, the kinetics of the bystander response, in contrast to the cognate response, were not accelerated in the presence of primed Th cells. Adoptive recipients reconstituted with primed Th cells developed accelerated cognate but not bystander antibody response, as compared with unprimed recipients. This phenomenon may reflect a regulatory mechanism invoked to limit the potentially harmful effects of nonspecific help. It was observed that while animals are tolerant to immunization with mouse (self) hemoglobin, immunization with a mixture containing mouse hemoglobin plus fowl gamma globulin resulted in the production of hemoglobin-binding autoantibodies. Thus bystander help induced by coimmunization may serve as a model for the induction of autoantibodies during normal immune responses in vivo.
Vascular Image Patterns of Lymph Nodes for the Prediction of Metastatic Disease During EBUS-TBNA for Mediastinal Staging of Lung Cancer
Authors: Takahiro Nakajima, Takashi Anayama, Masato Shingyoji, Hideki Kimura, Ichiro Yoshino, Kazuhiro Yasufuku
Journal: Journal of Thoracic Oncology (2012)
AIDS, Nutrition, and Infection
Authors: Barry S. Renaler
Journal: Annals of Internal Medicine (1990)

Letters and Corrections1 September 1990AIDS, Nutrition, and InfectionBarry S. Renaler, PhDBarry S. Renaler, PhDSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-113-5-409_2 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editors: By focusing exclusively on the early administration of zidovudine to persons who are positive for the human immunodeficiency virus (HIV), Ruedy and colleagues (1) in their recent editorial imply that this approach represents the only viable intervention strategy to delay the development of HIV-associated disease. This position appears to be at variance with well-documented interactions among infectious disease, nutritional status, and immune function (2). Infectious diseases influence the host's nutritional status and vice versa, and both factors significantly affect immune function. Even marginal deficiencies of single nutrients can severely impair immunologic processes and thereby alter the disease...References1. RuedySchechterMontaner JMJ. Zidovudine for early human immunodeficiency virus (HIV) infection: who, when, and how? Ann Intern Med. 1990;112:721-3. LinkGoogle Scholar2. Beisel W. Single nutrients and immunity. Am J Clin Nutr. 1982; 35(Suppl):417-68. CrossrefMedlineGoogle Scholar3. JainChandra VR. Does nutritional deficiency predispose to acquired immune deficiency syndrome? Nutr Res. 1984;4:537-43. CrossrefGoogle Scholar4. ArcherGlinsmann DW. Intestinal infection and malnutrition initiate acquired immune deficiency syndrome (AIDS). Nutr Res. 1985;5:9-19. CrossrefGoogle Scholar5. CassilethLuskStrouseBodenheimer BETB. Contemporary unorthodox treatments in cancer medicine: a study of patients, treatments, and practitioners. Ann Intern Med. 1984;101:105-12. LinkGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byLagging behindMalnutrition associated with HIV/AIDS. Part one: Definition and scope, epidemiology, and pathophysiology 1 September 1990Volume 113, Issue 5Page: 409-410KeywordsAIDSHIVInfectious disease immunologyInfectious diseasesNutrientsNutrition ePublished: 1 December 2008 Issue Published: 1 September 1990 PDF downloadLoading ...
Intraductal Papilloma of the Breast: F-18 FDG PET Demonstration
Authors: Ba D. Nguyen, Thomas K. Lidner
Journal: Clinical Nuclear Medicine (2005)

F-18 FDG PET is a useful imaging modality in breast carcinoma for detection of recurrent disease, unsuspected regional and distant metastases, and in monitoring cancer response to therapy. Although preliminary results showed PET capable of differentiating benign from malignant diseases, the role of PET in primary breast tumor identification has limitations with the small size and certain histologic characteristics of the tumors, and inflammatory and infectious processes. To the list of false-positive PET results, the authors add a case of intraductal papilloma incidentally detected by PET during staging of intestinal adenocarcinoma.
Dermatitis herpetiformis: immune complex detection with CIq and monoclonal rheumatoid factor
Authors: ROBERT E. JORDON, GERHARD TAPPEINER, JANE C. KAHL, KLAUS WOLFF
Journal: British Journal of Dermatology (1981)

To determine the significance of circulating immune complexes in dermatitis herpetiformis, serum samples from thirty patients with active disease were tested by a CIq binding radioassay, while serum samples from twenty‐one of these patients were tested by a monoclonal rheumatoid factor (mRF) inhibition radioassay. By direct immunofluorescence, all patients demonstrated typical IgA deposition in dermal papillae. Using the Ci q binding assay, only seven of forty‐two serum samples had elevated Ci q binding activity, while by the mRF inhibition assay, thirteen of twenty‐five samples had elevated immune complex levels. Nine of these latter thirteen positive serum samples, however, were minimally elevated. Thus, IgG and/or IgM containing immune complexes are infrequently present, or at very low levels, in sera of patients with active dermatitis herpetiformis.
Anastomotic Leak After Low Anterior Resection
Authors: Hannah Caulfield, Neil H. Hyman
Journal: JAMA Surgery (2013)

Anastomotic leak is a potentially devastating complication of bowel surgery, yet a leak can refer to a range of clinical problems, with disparate treatment and outcomes.To qualitatively categorize the spectrum of anastomotic leaks that occur after low anterior resection for rectal cancer and to describe their effect on outcomes.Retrospective review of a prospective database at an academic teaching hospital.Two hundred ten patients with at least 1 year of follow-up data.Low anterior resection for rectal cancer.Anastomotic leak, associated treatment, and need for permanent stoma creation.Of 198 study patients, 168 had no demonstrated anastomotic leak, free fluid, or abscess at any time after surgery. Of the remaining 30 patients, 17 had extravasation of contrast medium into the peritoneal cavity or the presacral space on a postoperative imaging study, some long after surgery. Six to 9 of these patients seemed to meet usual clinical criteria for anastomotic leak. Ten patients had only free or simple pelvic fluid collection without extravasation of contrast medium, and 3 patients had an abscess near the anastomotic site without extravasation of contrast medium. Male sex, diabetes mellitus, and radiation therapy (but not cigarette smoking) increased the risk for anastomotic leak. Anastomotic leak was correlated with the requirement for permanent stoma creation, while only free anastomotic leak was associated with an increased incidence of irregular bowel function. Notably, simple fluid without extravasation of contrast medium also correlated with irregular bowel function.A spectrum of clinical entities may be considered to represent an anastomotic leak after low anterior resection, with differing consequences. Presacral and free extravasation of contrast medium led to an increased need for permanent diversion, but even simple pelvic fluid collections were associated with irregular bowel function.
Recurrent Oral Mucosal Ulcerations and Gingival Edema
Authors: Faizan Alawi, Martin S. Greenberg, Eric T. Stoopler
Journal: JAMA Dermatology (2014)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Dermatology HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Dermatology journal
FUNCTIONAL HEART DISEASE
Authors: Louis H. Sigler
Journal: JAMA (1952)

<h3>To the Editor:</h3> —I would like to comment on the paper entitled "The Frequency of Functional Heart Disturbances" by Arthur M. Master (<i>J. A. M. A.</i><b>150:</b>195 [Sept. 20] 1952). I feel that the term functional in relation to heart disease should be used only in classifying the functional capacity of the diseased heart in performing work, as is currently done. We ought not employ the term also to denote the various subjective and objective disturbances of the heart or in the region of the heart in the presence or absence of structural disease of that organ. Such usage will not add to an understanding of the basic causes of such disturbances. It should be understood that underlying causes of such disturbances in the absence of structural heart disease are various constitutional abnormalities or diseases. They include among many other conditions reflex disturbances from diseased structures or organs adjacent
New perspectives on sleep disturbances and memory in human pathological and psychopharmacological states
Authors: Margaret A. Piggott, Elaine K. Perry
Journal: Behavioral and Brain Sciences (2005)

Matthew Walker's article has prompted us to consider neuropsychiatric disorders and pharmacological effects associated with sleep alterations, and aspects of memory affected. Not all disorders involving insomnia show memory impairment, and hypersomnias can be associated with memory deficits. The use of cholinergic medication in dementia indicates that consideration of the link between sleep and memory is more than academic.
Effects of recombinant human growth hormone on muscle protein turnover in malnourished hemodialysis patients.
Authors: G Garibotto, A Barreca, R Russo, A Sofia, P Araghi, A Cesarone, M Malaspina, F Fiorini, F Minuto, A Tizianello
Journal: Journal of Clinical Investigation (1997)

To assess the effect of recombinant human growth hormone (rhGH) on muscle protein metabolism in uremic patients with malnutrition, forearm [3H]phenylalanine kinetics were evaluated in six chronically wasted (body weight 79% of ideal weight) hemodialysis (HD) patients in a self-controlled, crossover study. Forearm protein dynamics were evaluated before, after a 6-wk course of rhGH (5 mg thrice weekly) and after a 6-wk washout period. After rhGH: (a) forearm phenylalanine net balance--the difference between phenylalanine incorporation into and phenylalanine release from muscle proteins--decreased by 46% (-8+/-2 vs. -15+/-2 nmol/min x 100 ml at the baseline and -11+/-2 after washout, P < 0.02); (b) phenylalanine rate of disposal, an index of protein synthesis, increased by 25% (25+/-5 vs. 20+/-5 at the baseline and 20+/-4 after washout, P < 0.03); (c) phenylalanine rate of appearance, an index of protein degradation, was unchanged (33+/-5 vs. 35+/-5 at the baseline and 31+/-4 after washout); (d) forearm potassium release declined (0.24+/-0.13 vs. 0.60+/-0.15 microeq/min at the baseline, and 0.42+/-0.20 microeq/min after washout P < 0.03); (e) changes in the insulin-like growth factor binding protein (IGFBP)-1 levels and insulin-like growth factor-I (IGF-I)/IGFBP-3 ratios accounted for 15.1% and 47.1% of the percent variations in forearm net phenylalanine balance, respectively. Together, these two factors accounted for 62.2% of variations in forearm net phenylalanine balance during and after rhGH administration. These data indicate: (a) that rhGH administration in malnourished hemodialysis patients is followed by an increase in muscle protein synthesis and by a decrease in the negative muscle protein balance observed in the postabsorptive state; and (b) that the reduction in net protein catabolism obtained with rhGH can be accounted for by the associated changes in circulating free, but not total, IGF-I levels.