Hormone Therapy Suspension and Mammography in Women's Health Initiative Clinical Trials
Authors: Rowan T. Chlebowski
Journal: Annals of Internal Medicine (2010)

Letters19 January 2010Hormone Therapy Suspension and Mammography in Women's Health Initiative Clinical TrialsRowan T. Chlebowski, MD, PhD and Marcia L. Stefanick, PhDRowan T. Chlebowski, MD, PhDFrom Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, Torrance, CA 90502; and Stanford University, Palo Alto, CA 94305.Search for more papers by this author and Marcia L. Stefanick, PhDFrom Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, Torrance, CA 90502; and Stanford University, Palo Alto, CA 94305.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-152-2-201001190-00022 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:The findings of Buist and colleagues (1) are addressed and expanded on by those of the WHI (Women's Health Initiative). In the WHI clinical trial evaluating estrogen plus progestin (2), 16 608 postmenopausal women were randomly assigned to combined hormone therapy or placebo. When the trial intervention was ended, women were informed by letter to stop taking study pills that day. Almost all did. Women in the combined estrogen plus progestin group had significantly more mammograms that required a physician-directed intervention (those in which short-interval follow-up was suggested, those with suspicious abnormalities, and those highly suggestive of malignant ...References1. Buist DS, Anderson ML, Reed SD, Aiello Bowles EJ, Fitzgibbons ED, Gandara JC, et al. Short-term hormone therapy suspension and mammography recall: a randomized trial. Ann Intern Med. 2009;150:752-65. [PMID: 19487710] LinkGoogle Scholar2. Chlebowski RT, Hendrix SL, Langer RD, Stefanick ML, Gass M, Lane D, et al; WHI Investigators. Influence of estrogen plus progestin on breast cancer and mammography in healthy postmenopausal women: the Women's Health Initiative Randomized Trial. JAMA. 2003;289:3243-53. [PMID: 12824205] CrossrefMedlineGoogle Scholar3. Chlebowski RT, Anderson G, Pettinger M, Lane D, Langer RD, Gilligan MA, et al; Women's Health Initiative Investigators. Estrogen plus progestin and breast cancer detection by means of mammography and breast biopsy. Arch Intern Med. 2008;168:370-7; quiz 345. [PMID: 18299491] Google Scholar4. McTiernan A, Martin CF, Peck JD, Aragaki AK, Chlebowski RT, Pisano ED, et al; Women's Health Initiative Mammogram Density Study Investigators. Estrogen-plus-progestin use and mammographic density in postmenopausal women: Women's Health Initiative randomized trial. J Natl Cancer Inst. 2005;97:1366-76. [PMID: 16174858] CrossrefMedlineGoogle Scholar5. Stefanick ML, Anderson GL, Margolis KL, Hendrix SL, Rodabough RJ, Paskett ED, et al; WHI Investigators. Effects of conjugated equine estrogens on breast cancer and mammography screening in postmenopausal women with hysterectomy. JAMA. 2006;295:1647-57. [PMID: 16609086] CrossrefMedlineGoogle Scholar Author, Article, and Disclosure InformationAuthors: Rowan T. Chlebowski, MD, PhD; Marcia L. Stefanick, PhDAffiliations: From Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, Torrance, CA 90502; and Stanford University, Palo Alto, CA 94305.Disclosures: None disclosed. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoShort-Term Hormone Therapy Suspension and Mammography Recall Diana S.M. Buist , Melissa L. Anderson , Susan D. Reed , Erin J. Aiello Bowles , E. Dawn Fitzgibbons , Juleann C. Gandara , Deborah Seger , and Katherine M. Newton Metrics 19 January 2010Volume 152, Issue 2Page: 133KeywordsClinical trialsEstrogensHormonal therapyHormonesHysterectomyMammographyMenstrual cycleObstetrics and gynecologyRandomized trials ePublished: 19 January 2010 Issue Published: 19 January 2010 Copyright & PermissionsCopyright © 2010 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...