GASTRIC ACID SECRETION IN DIABETES MELLITUS
Authors: I N MARKS, C R SHUMAN, H SHAY
Journal: Annals of Internal Medicine (1959)

Article1 August 1959GASTRIC ACID SECRETION IN DIABETES MELLITUSI. N. MARKS, CHARLES R. SHUMAN, F.A.C.P., HARRY SHAY, F.A.C.P.I. N. MARKS, CHARLES R. SHUMAN, F.A.C.P., HARRY SHAY, F.A.C.P.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-51-2-227 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptEarlier investigators have noted a high incidence of achlorhydria among diabetic patients. Bowen and Aaron1 found achlorhydria in 29% of 61 diabetic subjects, and Marble2 reported an incidence of 32.8% in a collected series of 399 such patients. Various modifications of the Ewald test were employed in these studies, and the results in many series were biased by the inclusion of diabetic patients known to have gastrointestinal disorders. The status of gastric secretion in diabetes mellitus does not appear to have been studied with more refined methods.The augmented histamine test,3based on maximal histamine stimulation, is perhaps the most...Bibliography1. BowenAaron BDAH: Gastric secretion in diabetes mellitus, Arch. Int. Med. 37: 674, 1926. CrossrefGoogle Scholar2. Marble A: The digestive system in diabetes, in Joslin, E. P., Root, H. R., White, P., and Marble, A.: The treatment of diabetes mellitus, 9th Ed., 1952, Lea & Febiger, Philadelphia, p. 446. Google Scholar3. Kay AW: Effect of large doses of histamine on gastric secretion of HCl, Brit. M. J. 2: 77, 1953. CrossrefMedlineGoogle Scholar4. MarksShay INH: A comparison between the augmented histamine, Ewald and Diagnex tests, in press. Google Scholar5. MarksShay INH: The augmented histamine test, in press. Google Scholar6. Sircus W: The surgery of peptic ulcers, Wells, C. A., Editor, 1958, Livingstone, Edinburgh. Google Scholar7. Marks IN: The relationship of the acid output to the parietal cell population of the stomach, Scottish M. J. 1: 242, 1956. Google Scholar8. MarksKomarovShay INSAH: Acid secretion and the parietal cell mass, American Medical Association Scientific Exhibit, 1956. Google Scholar9. CardMarksSircus WIINW: Observations on achlorhydria, J. Physiol 130: 18P, 1955. Google Scholar10. ShayKomarovBerk HSAJE: Some fallacies in the clinical measurement of gastric acidity with special reference to the histamine test, Gastroenterology 15: 110, 1950. CrossrefMedlineGoogle Scholar11. CardSircus WIW: Modern trends in gastroenterology, 2nd Series, 1957, Butterworth, London, p. 177. Google Scholar12. FolinWu OH, in Hawk, P. B., Oser, B. L., and Summerson, W. H.: Practical physiological chemistry, 12th Ed., 1951, The Blakiston Company, Philadelphia, p. 520. Google Scholar13. Rabinowitch IM: Achlorhydria and its clinical significance in diabetes mellitus, Am. J. Digest. Dis. 16: 322, 1949. CrossrefMedlineGoogle Scholar14. RabinowitchFowlerWatson IMAFBA: Gastric acidity in diabetes mellitus, Arch. Int. Med. 47: 384, 1931. CrossrefGoogle Scholar15. WiechmannElzas EJ, cited by Rabinowitch, Fowler and Watson.14 Google Scholar16. Martin MM: Diabetic neuropathy, Brain 76: 594, 1953. CrossrefMedlineGoogle Scholar17. RootWhite HFP: Diabetes mellitus, 1956, Landsberger, New York, p. 162. Google Scholar18. BergeWollaegerScholzRookeSprague KGEEDAEDRE: Steatorrhea complicating diabetes mellitus with neuropathy, Diabetes 5: 25, 1956. CrossrefMedlineGoogle Scholar19. Joslin EP: Treatment of diabetes mellitus, 4th Ed., 1928, Lea and Febiger, Philadelphia, p. 716. Google Scholar20. Falta W: Die Zuckerkrankheit, 1936, Urban und Schwarzenberg, Berlin, p. 116. Google Scholar21. Wilder RM: Clinical diabetes mellitus and hyperinsulinism, 1940, W. B. Saunders Company, Philadelphia, p. 303. Google Scholar22. CrozierDanowskiGirdany PATSBR: Radiologic studies in diabetes mellitus (unpublished data), cited by Danowski, T. S.: Diabetes mellitus, 1957, The Williams and Wilkins Company, Baltimore, p. 448. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Philadelphia, Pennsylvania*Received for publication December 2, 1958.From the Fels Research Institute and Diabetic Service, Temple University Medical Center, Philadelphia, Pennsylvania.Requests for reprints should be addressed to Harry Shay, M.D., Fels Research Institute, Temple University School of Medicine, Philadelphia 40, Pennsylvania. 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