tbuckley/cabot-search huggingface dataset:
Balancing the Risks and Benefits of Rituximab
Authors: Eleni Linos
Journal: JAMA Internal Medicine (2013)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Internal Medicine HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Internal Medicine journal
The laryngeal mask airway and flexible bronchoscopy.
Authors: J Brimacombe
Journal: Thorax (1991)

Percutaneous biopsy of mediastinal tumours under sonographic guidance In his editorial (March 1991;46:157-9) Dr K Wernecke states that sarcomas and other rare primary mediastinal tumours cannot be diag- nosed accurately by percutaneous biopsy even on the basis of large tissue cylinders.I would beg to disagree with him on this issue.Large cylinders of tissue obtained with wide bore needles can be sufficient for diagnosis even of these rare lesions.There have been great advances in the application of immunocytochemical markers to aid in the diagnosis of soft tissue tumours.'In addition, germ cell tumours can be accurately typed by means of several markers, such as human chorionic gonadotrophin, a fetoprotein, and placental aLkaline phosphatase.'Use of these markers can help the pathologist to come to a firm diagnosis even with formalin fixed material.Several sections can be obtained from these cylinders of tissue and the appropriate antibodies applied.We have recently been able to obtain sufficient tissue cylinders with the biopty gun needle (Radioplast, Sweden) from lesions in the peripheral lung to give a correct diagnosis in most cases, using both light microscopy and immuno- cytochemistry.'
Failure of the Ipsogen MutaScreen kit to detect the JAK2 617V&gt;F mutation in samples with additional rare exon 14 mutations: implications for clinical testing and report of a novel 618C&gt;F mutation in addition to 617V&gt;F
Authors: Ilka Warshawsky, Frank Mularo, Carol Hren, Maureen Jakubowski
Journal: Blood (2010)
Cutaneous abscess: a rare complication of Streptobacillus moniliformis infection
Authors: E. Vasseur, P. Joly, M. Nouvellon, A. Laplagne, Ph. Lauret
Journal: British Journal of Dermatology (1993)

Journal Article Cutaneous abscess: a rare complication of Streptobacillus moniliformis infection Get access E. Vasseur, E. Vasseur Department of Dermatology, Hopital Charles Nicolle. 7600 Rouen, France Search for other works by this author on: Oxford Academic Google Scholar P. Joly, P. Joly Department of Dermatology, Hopital Charles Nicolle. 7600 Rouen, France Search for other works by this author on: Oxford Academic Google Scholar M. Nouvellon, M. Nouvellon Department of Microbiology, Hopital Charles Nicolle. 7600 Rouen, France Search for other works by this author on: Oxford Academic Google Scholar A. Laplagne, A. Laplagne Department of Dermatology, Hopital Charles Nicolle. 7600 Rouen, France Search for other works by this author on: Oxford Academic Google Scholar Ph. Lauret Ph. Lauret Department of Dermatology, Hopital Charles Nicolle. 7600 Rouen, France Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 129, Issue 1, 1 July 1993, Pages 95–96, https://doi.org/10.1111/j.1365-2133.1993.tb03323.x Published: 01 July 1993
An intestinal arsonist: pathobiont ignites IBD and flees the scene
Authors: Stefan Jellbauer, Manuela Raffatellu
Journal: Gut (2013)

<h3>Abstract</h3> Prediction during language comprehension has increasingly been suggested to play a substantive role in efficient language processing. Emerging models have postulated that predictive mechanisms are enhanced when neural networks fire synchronously, but to date, this relationship has been investigated primarily through oscillatory activity in narrow frequency bands. A recently-developed measure proposed to reflect broadband neural activity – and thereby synchronous neuronal firing – is 1/<i>f</i> neural noise extracted from EEG spectral power. Previous research (Voytek et al., 2015) has indicated that this measure of 1/<i>f</i> neural noise changes across the lifespan, and these neural changes predict age-related behavioral impairments in visual working memory. Using a cross-sectional sample of young and older adults, we examined age-related changes in 1/<i>f</i> neural noise and whether this measure would predict ERP correlates of successful lexical prediction during discourse comprehension. 1/<i>f</i> neural noise across two different language tasks revealed high within-subject correlations, indicating that this measure can provide a reliable index of individualized patterns of neural activation. In addition to age, 1/<i>f</i> noise was a significant predictor of N400 effects of successful lexical prediction, but noise did not mediate age-related declines in other ERP effects. We discuss broader implications of these findings for theories of predictive processing, as well as potential applications of 1/<i>f</i> noise across research populations.
INDUSTRY ISSUES: Pharmaceutical Factories as a Source of Drugs in Water
Authors: Rebecca Kessler
Journal: Environmental Health Perspectives (2010)

A large fraction of emissions of carbon dioxide (CO 2 )-the greenhouse gas produced by human activities in the greatest quantities-is long lived in the atmosphere, so decisions made today to continue adding CO 2 into the atmosphere may lock future generations into a range of human health and environmental impacts, some of which could become very severe, according to a committee of the National Research Council (NRC).In a report that looks at the short-and long-term effects of the stabilization of Earth's temperature, the NRC committee quantifies, as much as possible, the outcomes of different stabilization targets for the planet, with a focus on the United States. 1The report synthesizes global warming science in myriad fields along with research on the potential impacts for human health and other arenas.Then the committee adds a twist: rather than expressing climate goals in terms of stabilizing atmospheric concentrations of CO 2 , the authors assess such goals using global mean temperature change as the primary metric.The twist allows the authors to link the potential impacts from climate change more directly to temperature change.Research to date suggests many potential impacts can be directly linked to temperature, or to things that can be themselves linked to temperature (e.g., precipitation), although some (e.g., ocean acidification) are linked directly to CO 2 concentration, says Damon Matthews of Concordia University, a report coauthor."But in this report we were . . .noting the additional impacts you would expect for a given degree
Two main genetic pathways lead to the transformation of chronic lymphocytic leukemia to Richter syndrome
Authors: Ekaterina Chigrinova, Andrea Rinaldi, Ivo Kwee, Davide Rossi, Paola M. V. Rancoita, Jonathan C. Strefford, David Oscier, Kostas Stamatopoulos, Theodora Papadaki, Francoise Berger, Ken H. Young, Fiona Murray, Richard Rosenquist, Timothy C. Greiner, Wing C. Chan, Ester M. Orlandi, Marco Lucioni, Roberto Marasca, Giorgio Inghirami, Marco Ladetto, Francesco Forconi, Sergio Cogliatti, Hana Votavova, Steven H. Swerdlow, Stephan Stilgenbauer, Miguel A. Piris, Andras Matolcsy, Dominic Spagnolo, Eugene Nikitin, Alberto Zamò, Valter Gattei, Govind Bhagat, German Ott, Emanuele Zucca, Gianluca Gaidano, Francesco Bertoni
Journal: Blood (2013)
Bacteriological and Clinical Studies with Phenoxybenzylpenicillin
Authors: M. J. Carter, W. Brumfitt
Journal: BMJ (1962)

PHENOXYBENZYLPENICILLIN.EBRnuTsoInitial clinical trials have been carried out which demonstrate the effectiveness of this penicillin against a variety of penicillin-sensitive organisms at a dosage lower than that normally recommended for other oral preparations.Results of these trials are reported by Carter and Brumfitt (1962).Summary PhenoxybenzylpeniciUin is a new acid-stable, orally active penicillin chemically related to penicillins G and V and to phenethicillin.In vitro its antibacterial spectrum and minimum inhibitory concentration against sensitive organisms has been shown to be similar to those of penicillin V and phenethicillin.Studies in human volunteers at two dosage levels show that phenoxybenzylpenicillin gives higher and more prolonged therapeutic blood levels than penicillin V and phenethicillin.At the dose of 125 mg.phenoxybenzyl-penicillin gave a peak blood level greater than that from 250 mg. of penicillin V.Pharmacological tests have demonstrated a low oral toxicity.No allergic reactions were encountered, but phenoxybenzylpenicillin is likely to be similar to other penicillins in this respect.The results suggest that phenoxybenzylpenicillin should have therapeutic advantages over existing oral penicillins and should be effective in lower dose levels at longer time intervals.We acknowledge the contributions of our colleagues at Epsom, Bromborough, and Speke in this work.
ABC of antithrombotic therapy: Venous thromboembolism: treatment strategies
Authors: A. G G Turpie
Journal: BMJ (2002)

Evidence continues to accumulate on the rising burden of diabetes mellitus at a higher pace in Africa. In a series of two papers, we sought to summarise recent evidence on diabetes and obesity in Africa based on a systematic review of studies published between January 2002 and October 2012. This first paper on the prevalence, pathogenesis and comorbidities shows that the increase in diabetes prevalence has paralleled that of obesity in Africa. Recent surveys on diabetes and obesity have been largely suboptimal. Hence, the need for more representative and robust continent-wide prevalence figures, which may be somehow achieved through pooling of existing data. Prospective studies linking environmental risk factors to disease occurrence and outcomes remain scarce, and genetic factors for diabetes or obesity have not been extensively assessed. The health consequences of diabetes are manifold, and include a complex interaction with other conditions like HIV infection and sickle cell disease/trait.
A Phase I Clinical and Pharmacokinetic Study of Oral CI-1033 in Combination with Docetaxel in Patients with Advanced Solid Tumors
Authors: Linda L. Garland, Manuel Hidalgo, David S. Mendelson, David P. Ryan, Banu K. Arun, Jennifer L. Lovalvo, Irene A. Eiseman, Stephen C. Olson, Peter F. Lenehan, Joseph P. Eder
Journal: Clinical Cancer Research (2006)

Abstract Purpose: CI-1033 is an orally available 4-anilinoquinazolone irreversible tyrosine kinase inhibitor of erbB-1, erbB-2, and erbB-4. We conducted a dose escalation study of CI-1033 with docetaxel to assess the safety profile and pharmacokinetics of the combination and to establish the maximum tolerated dose. Experimental Design: Twenty-six patients with advanced solid tumors were treated on four dosing cohorts starting at CI-1033 (50 mg/d) + docetaxel (75 mg/m2). An intermittent dosing schedule avoided concurrent drug dosing. Results: CI-1033 alone was escalated from 50 to 75 mg/d (dose level 2), where diarrhea was dose limiting; a 38% incidence of cycle 1 febrile neutropenia prompted dose de-escalation of both CI-1033 and docetaxel for dose level 3, where dose-limiting toxicities prompted further de-escalation of CI-1033 to 45 mg/d. Given equivalent safety profiles for dose level 1 [CI-1033 (50 mg/d) + docetaxel (75 mg/m2)] and dose level 4 [CI-1033 (45 mg/d) + docetaxel (60 mg/m2)], the former was determined to be the recommended phase II dose, given greater dose intensity of both drugs. Antitumor activity was noted in three patients, including a complete response in a patient with cervix uteri cancer. Pharmacokinetic analysis showed a possible effect of docetaxel on CI-1033 pharmacokinetics. Conclusions: It is feasible to combine the irreversible pan-erbB tyrosine kinase inhibitor CI-1033 with docetaxel on an intermittent dosing schedule in advanced cancer patients. We established the maximum tolerated dose and recommended phase II dose for the combination. Further investigation of this combination should include a rigorous analysis of the effect of docetaxel on CI-1033 pharmacokinetics.
Annexin A1–containing extracellular vesicles and polymeric nanoparticles promote epithelial wound repair
Authors: Giovanna Leoni, Philipp-Alexander Neumann, Nazila Kamaly, Miguel Quiros, Hikaru Nishio, Hefin R. Jones, Ronen Sumagin, Roland S. Hilgarth, Ashfaqul Alam, Gabrielle Fredman, Ioannis Argyris, Emile Rijcken, Dennis Kusters, Chris Reutelingsperger, Mauro Perretti, Charles A. Parkos, Omid C. Farokhzad, Andrew S. Neish, Asma Nusrat
Journal: Journal of Clinical Investigation (2015)

Epithelial restitution is an essential process that is required to repair barrier function at mucosal surfaces following injury. Prolonged breaches in epithelial barrier function result in inflammation and further damage; therefore, a better understanding of the epithelial restitution process has potential for improving the development of therapeutics. In this work, we demonstrate that endogenous annexin A1 (ANXA1) is released as a component of extracellular vesicles (EVs) derived from intestinal epithelial cells, and these ANXA1-containing EVs activate wound repair circuits. Compared with healthy controls, patients with active inflammatory bowel disease had elevated levels of secreted ANXA1-containing EVs in sera, indicating that ANXA1-containing EVs are systemically distributed in response to the inflammatory process and could potentially serve as a biomarker of intestinal mucosal inflammation. Local intestinal delivery of an exogenous ANXA1 mimetic peptide (Ac2-26) encapsulated within targeted polymeric nanoparticles (Ac2-26 Col IV NPs) accelerated healing of murine colonic wounds after biopsy-induced injury. Moreover, one-time systemic administration of Ac2-26 Col IV NPs accelerated recovery following experimentally induced colitis. Together, our results suggest that local delivery of proresolving peptides encapsulated within nanoparticles may represent a potential therapeutic strategy for clinical situations characterized by chronic mucosal injury, such as is seen in patients with IBD.
P82 Episodic viral wheeze and multitrigger wheeze: are they really different phenotypes?
Authors: E. Livingstone, G. Noble, G. Walsh, S. Turner
Journal: Thorax (2011)

<h3>Introduction</h3> Episodic viral wheeze (EVW) and multitrigger wheeze (MTW) are thought to be distinct recurrent wheezing phenotypes in preschool children. Here we tested the hypothesis that there are detectable physiological differences between children with EVW and MTW. <h3>Methods</h3> Preschool children with and without a history of recurrent wheeze were recruited, those with symptoms were categorised as EVW or MTW. In a single assessment, the following were completed: questionnaire, respiratory resistance (Rint), bronchodilator response, nasal nitric oxide and skin prick reactivity. Exhaled breath condensate was collected and analysed for interleukin (IL) −10 concentration. A respiratory questionnaire was completed after 12 months. <h3>Results</h3> There were 69 children recruited, mean age 3.8 years (range 2.1–5.3), of whom 34 had EVW, 19 had MTW and 16 were controls. Skin prick reactivity was determined in 57, Rint in 55, bronchodilator response in 43, nasal NO in 42, exhaled breath condensate in 24 and follow-up was achieved in 53 children. Compared with MTW, children with EVW had increased Rint (mean difference 0.21 kPa.s/L [95% CI 0.06 to 0.36]). Children with MTW were 4.0 times more likely [95% CI 1.1 to 14.7] to be atopic compared with those with EVW. Compared with controls, children with EVW and MTW had reduced IL-10 concentration in exhaled breath condensate (mean difference 1.35 pg/ml [95% CI 1.02 to 1.87]. After 12 months, wheeze had apparently resolved in 27% (12/44) children and of the 30 with ongoing wheeze, 27% (3/11) with MTW were categorised as EVW and 52% (10/19) with EVW had developed MTW. <h3>Conclusions</h3> There are differences in lung function and atopy between children with EVW and MTW but with considerable overlap in values. The two phenotypes are not necessarily stable over time suggesting they are towards opposite ends of the same spectrum rather than different conditions.
Acute renal failure after infusion of gelatin
Authors: W J Fawcett
Journal: BMJ (1989)

perhaps fewer are ventilated in other hospitals.As computed tomographic scanners become available in more general hospitals, fewer hopeless cases of head injury (and cases of intracranial haemorrhage) are likely to be referred to neurosurgeons.That could mean more potential donors in other hos- pitals.International comparisons of brain stem death and organ donation should allow for the fact that the incidence of fatal head injuries is two to three times greater in the United States, Canada, Australia, France, and Germany than in Britain and that the number of intensive care beds per head is 10 times greater in the United States.We hope that the further planned audits of deaths in intensive care units in England may throw more light on the factors that influence the yield of organ donors.
Reply to C. Eisenbach et al.
Authors: G. Payeras, J. Piqueras, J. Moreno Vara
Journal: Endoscopy (2007)

Eosinophilic esophagitis is a rare clinicopathological disorder characterized by an infiltration of eosinophilic leukocytes in the esophageal mucous membrane. Recent clinical studies suggest an allergic cause but the precise allergen remains unknown and is probably unique to each patient [1] [2]. The epidemiology of eosinophilic esophagitis has not been studied to any great extent, but it appears to be a new disease that is increasing in incidence. Some studies even suggest a prevalence that reaches near-epidemic proportions [3].
US Senate outlaws genetic discrimination
Authors: Janice Hopkins Tanne
Journal: BMJ (2008)

A report from the Association of American Medical Colleges suggests that all 129 member medical schools should prohibit pharmaceutical and devices manufacturers from providing gifts, food, and travel to doctors, faculty members, and students.The report will be considered at the association's meeting in June.The association set up a task force to examine industry funding and to guide the association, medical schools, and teaching hospitals in developing policies and procedures about gifts and funding from industry.The report said that medical schools and teaching hospitals had become increasingly dependent on industry support for their core educational missions."This reliance raises concerns because such support, including gifts, can influence the objectivity and integrity of academic teaching, learning, and practice, thereby calling into question the commitment of academia and industry together to promote the public's interest by fostering the most cost-effective, evidencebased medical care possible."The report called on academic medical centers "to accelerate their adoption of policies that better manage, and when necessary, prohibit, academic-industry interactions that can inherently create conflicts of interest and undermine standards of professionalism."It concluded, "Industry should voluntarily discontinue those practices that compromise professionalism as well as public trust."The New York Times noted that medical schools, with their prominent professors and impressionable trainees, were particularly attractive targets for marketing (28 April; www.nytimes.com/
Interferon-α Inhibition by Intravenous Immunoglobulin Is Independent of Modulation of the Plasmacytoid Dendritic Cell Population in the Circulation: Comment on the Article by Wiedeman et al
Authors: Meenu Sharma, Chaitrali Saha, Yoland Schoindre, Laurent Gilardin, Olivier Benveniste, Srini V. Kaveri, Jagadeesh Bayry
Journal: Arthritis & Rheumatology (2014)
Obesity increases risk of pulmonary embolism
Authors: J. Westall
Journal: BMJ (1997)

The main risk factors for coronary heart disease–obesity, smoking, and hypertension–are also associated with an increased risk of pulmonary embolism in women, according to a large prospective study.

The finding comes from the United States nurses' health study, which has 16 years of follow up data on 112822 female nurses aged 30-55 years ( JAMA 1997;277:642-5). Obesity, cigarette …
Crushed Chest and the Anesthesiologist
Authors: William Hamelberg
Journal: JAMA (1960)

Crushing injuries of the chest, notably with associated trauma of other parts of the body, require careful evaluation prior to anesthesia. Accordingly, roentgenograms should be obtained in suspected cases of pneumothorax; constant monitoring of breath sounds is essential. With blood loss there should be adequate replacement to stabilize the cardiovascular system. Positive pressure breathing may be helpful pending definitive care of the unstable thoracic wall. Endotracheal intubation in general anesthesia is a necessity to protect the lungs from aspiration of gastric contents and to improve the patient's respiratory exchange. Continuous epidural analgesia is valuable for the relief of pain, providing there is no evidence of other serious injury. It is emphasized that severely injured patients require minimum preoperative medication.
12 Wild-type HCV NS3 protease re-emerges during follow-up after 14 days of dosing with VX-950 in patients with genotype 1 HCV
Authors: T. Kieffer, C. Sarrazin, D. Bartels, B. Hanzelka, U. Müh, M. Welker, D. Wincheringer, C. Lin, S. Purdy, C. Weegink, H. Reesink, A. Kwong, S. Zeuzem
Journal: Journal of Hepatology (2006)
Doctors suspended for removing wrong kidney
Authors: O. Dyer
Journal: BMJ (2004)

Two doctors who mistakenly removed a patient's only working kidney have been suspended for 12 months by the General Medical Council.

Mr John Gethin Roberts, a consultant urologist, and registrar Mr Mahesh Goel faced the GMC's professional conduct committee 18 months after being acquitted of manslaughter in the death of 70 year old patient Graham Reeves.

Mr Reeves underwent what should have been a right nephrectomy at the Prince Philip Hospital in Llanelli, South Wales, in January 2000. But under Mr Roberts's supervision, Mr Goel removed the patient's left kidney in error.

On …