HEPATO-LENTICULAR DEGENERATION (WILSON'S DISEASE) FOLLOWING SPLENECTOMY; INTER-RELATIONSHIP OF THE RETICULO-ENDOTHELIAL AND CENTRAL NERVOUS SYSTEMS
Authors: A. M. Rabiner, Henry Joachim, I. S. Freiman
Journal: Annals of Internal Medicine (1941)

Article1 April 1941HEPATO-LENTICULAR DEGENERATION (WILSON'S DISEASE) FOLLOWING SPLENECTOMY; INTER-RELATIONSHIP OF THE RETICULO-ENDOTHELIAL AND CENTRAL NERVOUS SYSTEMSA. M. RABINER, M.D., HENRY JOACHIM, M.D., F.A.C.P., I. S. FREIMAN, M.D.A. M. RABINER, M.D.Search for more papers by this author, HENRY JOACHIM, M.D., F.A.C.P.Search for more papers by this author, I. S. FREIMAN, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-14-10-1781 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptIn two instances we have observed following splenectomy the rapid onset of symptoms indicating hepatolenticular degeneration. In both cases the operation had been performed because of anemia and purpura associated with splenomegaly. So far as we can determine, the development of the hepatolenticular syndrome has not hitherto been reported as a sequel in the clinical course of any cases of purpura in which splenectomy has been done. These cases therefore are being presented to record this occurrence, to direct attention to a possible contra-indication for splenectomy, and as a basis for discussion of the inter-relationship that we feel exists between...Bibliography1. WILSON SA: Progressive lenticular degeneration, Brain, 1912, xxxiv, 295. CrossrefGoogle Scholar2. BARNESHURST SEW: Hepato-lenticular degeneration, Brain, 1925, xlviii, 279. CrossrefGoogle Scholar3. VON LEHOCZKY T: Zur klinischen und anatomischen Diagnose der Wilson-pseudosklerose Krankheit, Deutsch. Ztschr. f. Nervenh., 1936, cxli, 28. CrossrefGoogle Scholar4. RYSTEDT G: Case of Wilson's disease, Acta med. Scand., 1923, lix, 377. Google Scholar5. BRÜCKNER JM: Bilateral progressive degeneration of lenticular nuclei, Jahrb. f. Kinderh., 1925, cx, 284. Google Scholar6. VAN BOGAERTWILLOCX LE: Dégenerescence hepato-lenticulaire, Rev. Neurol., 1936, lxvi, 461. Google Scholar7. GREENFIELDPOYNTONWALSHE JGFJFM: On progressive lenticular degeneration, Quart. Jr. Med., 1923-4, xvii, 385. Google Scholar8. BROUWER B: Spleen, liver, and brain, Proc. Roy. Soc. Med., 1936, xxix, 579. CrossrefGoogle Scholar9. CRANDALLWEIL LA: Pathology of the central nervous system in disease of the liver, Arch. Neurol. and Psychiat., 1933, xxix, 1066. CrossrefGoogle Scholar10. SCHERER HJ: Relation between liver and brain changes, Virchow's Arch. f. path. Anat., 1933, cclxxxviii, 333. Google Scholar11. ZIMMERMANYANNETT HMH: Kernicterus, Am. Jr. Dis. Child., 1933, xlv, 740. also: Cerebral sequelae of icterus gravis neonatorum, ibid., 1935, xlix, 418. CrossrefGoogle Scholar12. FITZGERALDGREENFIELDKOUNINE GMJGB: Neurological sequelae of kernicterus, Brain, 1939, lxii, 292. Google Scholar13. DEL RIO-HORTEGA P: Microglia, in PENFIELD, W.: Cytology and cellular pathology of the nervous system, 1932, Paul B. Hoeber, Inc., New York, ii, 483, 487. Google Scholar14. KERSHMAN J: Genesis of microglia in the human brain, Arch. Neurol. and Psychiat., 1939, xli, 24. CrossrefGoogle Scholar15. CUSHING H: The third circulation, Cameron Lectures, 1925, Edinburgh. Google Scholar16. SPATZ H: Über Stoffwechseleigentümlichkeiten in den Stammganglien, Ztschr. f. d. ges. Neurol. u. Psychiat., 1922, lxxviii, 641. CrossrefGoogle Scholar17. KING LS: Hematoencephalic barrier, Arch. Neurol. and Psychiat., 1939, xli, 51. CrossrefGoogle Scholar18. BALOKORPASSY JB: Encephalitis of dogs with Eck fistula fed on meat, Arch. Path., 1932, xiii, 80. Google Scholar19. MAHAIM I: Hepato-lenticular degeneration, Schweiz. Arch. Neurol. u. Psychiat., 1925, xvi, 252, and xvii, 43, and 283. Google Scholar20. KOLISKO A: Beiträge zur Kenntnis der Blutversorgung. d. Grosshirnganglien, Wien. klin. Wchnschr., 1893, vi, 191. Google Scholar21. RUGE : Quoted by Brückner. Google Scholar22. SPIELMEYER W: Anatomic substratum of the convulsive state, Arch. Neurol. and Psychiat., 1930, xxiii, 869. CrossrefGoogle Scholar23. VOGTO. C: Erkrankungen der Grosshirnrinde im Lichte der Topistik, Pathoklise, und Pathoarchitektonik, 1922, J. A. Barth, Leipzig. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Brooklyn, New York*Read in part at the 61st Annual Meeting of the American Neurological Association, Montreal, Canada, June 5, 1935. Received for publication November 26, 1940.From the Jewish Sanitarium and Hospital for Chronic Diseases, Brooklyn, N. Y., and the Department of Neuropathology, New York State Psychiatric Institute, New York, N. Y. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byBrain MRI and SPECT in the diagnosis of early neurological involvement in Wilson’s diseaseComparison of MRI, EEG, EPs and ECD-SPECT in Wilson's diseaseThe Liver in Wilson’s DiseaseLiver dysfunction in hepatolenticular degenerationCirrhosis of the liver in children 1 April 1941Volume 14, Issue 10Page: 1781-1801KeywordsAnemiaNervous systemNeuropathologySplenectomySplenomegaly ePublished: 1 December 2008 Issue Published: 1 April 1941 PDF downloadLoading ...