tbuckley/cabot-search huggingface dataset:
Winter Landscape in Deer Grove
Authors: M. Therese Southgate
Journal: JAMA (1999)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Stage, age, and EBV status impact outcomes of plasmablastic lymphoma patients: a clinicopathologic analysis of 61 patients
Authors: Sanam Loghavi, Khaled Alayed, Tariq N. Aladily, Zhuang Zuo, Siok-Bian Ng, Guilin Tang, Shimin Hu, C. Cameron Yin, Roberto N. Miranda, L. Jeffrey Medeiros, Joseph D. Khoury
Journal: Journal of Hematology & Oncology (2015)

Plasmablastic lymphoma (PBL) is a rare aggressive neoplasm with lymphoid and plasmacytic differentiation that is commonly associated with immunodeficiency and an unfavorable prognosis. Clinicopathologic features have been largely derived from cases reports and small series with limited outcome analyses.The demographic, clinicopathologic features, and clinical outcomes of a cohort of 61 patients with PBL were reviewed and analyzed.Patients had a median age of 49 years (range 21-83 years) and most (49/61; 80%) were men. Human immunodeficiency virus (HIV) status was available for 50 patients: 20 were HIV-positive and 30 HIV-negative. Twenty-three patients were immunocompetent. Abdominal/gastrointestinal complaints were the most common presenting symptoms, reported in 14 of 47 (30%) of patients. At presentation, 24 of 43 (56%) patients had stage III or IV disease. Epstein-Barr virus (EBV) was detected in 40 of 57 (70%) cases. MYC rearrangement was identified in 10/15 (67%) cases assessed, and MYC overexpression was seen in all cases assessed regardless of MYC rearrangement status. HIV-positive patients were significantly younger than those who were HIV-negative (median 42 vs. 58 years; p = 0.006). HIV-positive patients were also significantly more likely to have EBV-positive disease compared with HIV-negative patients (19/19, 100% vs. 15/29, 52%; p = 0.002). Patients who received CHOP chemotherapy tended to have better overall survival (OS) compared with those who received hyperfractionated cyclophosphamide, vincristine, doxorubicin, and dexamethasone (hyper-CVAD) (p = 0.078). HIV status had no impact on OS. Patients with EBV-positive PBL had a better event-free survival (EFS) (p = 0.047) but not OS (p = 0.306). Notably, OS was adversely impacted by age ≥ 50 years (p = 0.013), stage III or IV disease (p = <0.001), and lymph node involvement (p = 0.008).The most significant prognostic parameters in patients with PBL are age, stage, and, to a lesser extent, EBV status. In this study, two-thirds of PBL cases assessed were associated with MYC rearrangement and all showed MYC overexpression.
Prediction of Therapeutic Responses to Tocilizumab in Patients With Rheumatoid Arthritis: Biomarkers Identified by Analysis of Gene Expression in Peripheral Blood Mononuclear Cells Using Genome‐Wide DNA Microarray
Authors: Yoshie Sanayama, Kei Ikeda, Yukari Saito, Shin‐ichiro Kagami, Mieko Yamagata, Shunsuke Furuta, Daisuke Kashiwakuma, Itsuo Iwamoto, Takeshi Umibe, Yasushi Nawata, Ryutaro Matsumura, Takao Sugiyama, Makoto Sueishi, Masaki Hiraguri, Ken Nonaka, Osamu Ohara, Hiroshi Nakajima
Journal: Arthritis & Rheumatology (2014)

The aim of this prospective multicenter study was to identify biomarkers that can be used to predict therapeutic responses to tocilizumab in patients with rheumatoid arthritis (RA).We recruited patients with RA who were treated with tocilizumab for the first time, and determined therapeutic responses at 6 months. In the training cohort (n = 40), gene expression in peripheral blood mononuclear cells (PBMCs) at baseline was analyzed using genome-wide DNA microarray, with 41,000 probes derived from 19,416 genes. In the validation cohort (n = 20), expression levels of the candidate genes in PBMCs at baseline were determined using real-time quantitative polymerase chain reaction (qPCR) analysis.We identified 68 DNA microarray probes that showed significant differences in signal intensity between nonresponders and responders in the training cohort. Nineteen putative genes were selected, and a significant correlation between the DNA microarray signal intensity and the qPCR relative expression was confirmed in 15 genes. In the validation cohort, a significant difference in relative expression between nonresponders and responders was reproduced for 3 type I interferon response genes (IFI6, MX2, and OASL) and MT1G. Receiver operating characteristic curve analysis of models incorporating these genes showed that the maximum area under the curve was 0.947 in predicting a moderate or good response to tocilizumab in the validation cohort.Using genome-wide DNA microarray analyses, we identified candidate biomarkers that can be used to predict therapeutic responses to tocilizumab in patients with RA. These findings suggest that type I interferon signaling and metallothioneins are involved in the pathophysiology of RA.
JS-K, a GST-Activated Nitric Oxide Generator, Induces DNA-Double Strand Breaks and Inhibits Growth and Survival of Multiple Myeloma Cells In Vitro and In Vivo.
Authors: Tanyel Kiziltepe, Teru Hideshima, Noopur Raje, Kenji Ishitsuka, Enrique M. Ocio, Laurence Catley, Chun-Qi Li, Laura Trudel, Hiroshi Yasui, Norihiko Shirashi, Yu-Tzu Tai, Dharminder Chauhan, Constantine Mitsiades, Joseph E. Saavedra, Gerald N. Wogan, Larry K. Keefer, Paul J. Shami, Kenneth C. Anderson
Journal: Blood (2006)
Portable video media for presenting informed consent and wound care instructions for skin biopsies: a randomized controlled trial
Authors: A.W. Armstrong, A. Alikhan, L.S. Cheng, C. Schupp, C. Kurlinkus, D.B. Eisen
Journal: British Journal of Dermatology (2010)

Background In fast‐paced dermatology clinics, the process of obtaining informed consents for biopsies and providing postprocedure instructions may be incomplete and inconsistent. Objectives To compare effectiveness of video‐based education with that of verbal education for giving informed consent and providing postprocedure wound care instructions in patients undergoing skin biopsies. Methods In this randomized controlled trial, participants were randomized to receive either video education on portable video devices or conventional verbal instructions regarding skin biopsies. Participants completed a skin‐biopsy knowledge assessment, patient satisfaction assessment and evaluation of educational medium. Main outcome measures were differences in the changes in the prestudy and poststudy knowledge assessment scores, patient satisfaction and evaluation of the educational medium. Results Eight‐four patients undergoing skin biopsies at the University of California Davis dermatology clinic participated in the study. Participants in the control group had a nonstatistically significant increase in knowledge score (mean ± SD 1·12 ± 1·74), whereas those in the video group had a statistically significant increase in knowledge score (mean ± SD 1·55 ± 1·71). The difference in knowledge scores between the video and verbal groups was not statistically significant. Participants in both groups were highly satisfied with the biopsy education. On a 10‐point scale, the mean ± SD usefulness and appeal of the videos were 9·01 ± 1·5 and 9·01 ± 1·66, respectively. Conclusions Our study demonstrated a significant increase in knowledge score following video education, but not following oral education. Although between‐group comparisons did not achieve statistical significance, portable video media for presenting informed consent and wound care instructions for skin biopsies appear to be more effective and result in higher satisfaction than traditional oral education.
Interactions between ultraviolet light exposure and DNA repair gene polymorphisms may increase melanoma risk
Authors: J. Di Lucca, M. Guedj, V. Descamps, A. Bourillon, P. Dieudé, P. Saiag, P. Wolkenstein, N. Dupin, C. Lebbe, N. Basset-Seguin, B. Grandchamp, N. Soufir
Journal: British Journal of Dermatology (2010)
The Fifteen Minute Hour: Applied Psychotherapy for the Primary Care Physician.
Authors: Marian R. Stuart, Joseph Aloysius Lieberman Iii
Journal: Annals of Internal Medicine (1986)

The Relationship Between Mental and Physical Health - Implications of the New Medical Model How Patients React to Stress The Psychotherapeutic Qualifications of the Primary Care Physician Basic Principles and Strategies of Psychotherapeutic Change Differences in Approach to Therapy Between Primary Care Physicians and Psychiatrists The Structure of Therapy Rationale and Techniques for Fifteen Minute Therapy Contents of the Fifteen Minute Therapy Session Handling Special Patients Applied Psychotherapy for Special Situations, Staff and Physicians Anticipated Outcomes. Appendix: A Dozen Good Questions and Three Good Answers for All Seasons.
Interleukin-1 Receptor Signaling Mediates Atherosclerosis Associated With Bacterial Exposure and/or a High-Fat Diet in a Murine Apolipoprotein E Heterozygote Model
Authors: Hunghui Chi, Emmanuel Messas, Robert A. Levine, Dana T. Graves, Salomon Amar
Journal: Circulation (2004)

Background— Current data demonstrate that progressive atherosclerosis is associated with activation of the inflammatory process, as evidenced by systemic elevations of molecules such as tumor necrosis factor, interleukin (IL)-6, and IL-1. It has been postulated that inflammatory events within an atherogenic lesion are induced by oxidized LDL. Recent evidence suggests that infectious agents, including those that cause periodontal disease, may also play an important role. Studies presented here tested the hypothesis that IL-1 receptor (IL-1R1) signaling plays a crucial role in bacteria- and/or high-fat diet (HFD)–enhanced atherogenesis. Methods and Results— Ten-week-old ApoE +/− mice lacking either 1 IL-1R1 allele (ApoE +/− /IL-1R1 +/− ) or 2 IL-1R1 alleles (ApoE +/− /IL-1R1 −/− ) fed either an HFD or regular chow were inoculated intravenously with live Porphyromonas gingivalis ( P gingivalis ) (10 7 CFU), an important periodontal pathogen, or vehicle once per week for 14 or 24 consecutive weeks. Histomorphometry of plaque cross-sectional area in the proximal aortas, en face measurement of plaque area over the aortic trees, and ELISA for systemic proinflammatory mediators were performed. Atherosclerotic lesions of proximal aortas and aortic tree were substantially reduced in ApoE +/− /IL-1R1 −/− mice than in ApoE +/− /IL-1R1 +/− mice challenged with P gingivalis. At 24 weeks after P gingivalis inoculation, proximal aortic lesion size quantified by histomorphometry was 5-fold–reduced in chow-fed ApoE +/− /IL-1R1 −/− mice than in ApoE +/− /IL-1R1 +/− mice ( P &lt;0.05). In the HFD group, ApoE +/− /IL-1R1 −/− mice exhibited marked attenuation of the progression of atherosclerotic lesions (78% to 97%), with and without P gingivalis inoculation ( P &lt;0.05) Conclusion— Ablation of IL-1R1 under P gingivalis challenge and/or an HFD reduced the progression of atherosclerotic plaques. These results indicate that IL-1 plays a crucial role in bacteria- and/or HFD-enhanced atherogenesis.
Hormone replacement therapy
Authors: Rebekah Wang-Cheng, Jo Ann Rosenfeld
Journal: BMJ (2003)

The chapter begins with a discussion on growth hormone deficiency (GHD) in adults. The goals of GH therapy differ in children and adults. The chapter lists the causes of childhood-onset GHD as well as adult-onset GHD. GHD occurs when the pituitary gland is unable to produce sufficient quantities of GH to carry out its growth and metabolic tasks. Presently, the insulin tolerance test (ITT) and the growth hormone releasing hormone (GHRH)+arginine are considered the best tests to diagnose GHD. The chapter briefly discusses topics relevant to GHD in children and adolescents, such as recombinant human growth hormone treatment. It ends with a discussion on pituitary hormone replacement in women. Topics discussed include treatment of adrenocortotropic hormone (ACTH) deficiency, treatment of thyroid stimulating hormone (TSH) deficiency, gonadotroph deficiency, androgen replacement, GH replacement therapy, and vasopressin replacement therapy.
Management of field change in actinic keratosis
Authors: M. Vatve, J.-P. Ortonne, M.A. Birch-Machin, G. Gupta
Journal: British Journal of Dermatology (2007)

Field cancerization was first described in 1953 as histologically altered mucosa surrounding tumours removed from the upper gastro-intestinal tract. Over the years the definition has changed to include an area which is clinically occult but has multifocal preneoplastic changes, showing genetic mutations and which precedes the development of second primary tumours and local recurrences. Field cancerization has been described in the oropharynx, oesophagus, stomach, lung, colon, anus, cervix, bladder and skin. Various molecular techniques have been developed to look for genetic mutations and clonality in areas of field change. These studies have highlighted the need for early detection and treatment in order to prevent the development of tumours and local recurrences. In this article we examine the concept of field cancerization and treatments available to manage field change.
Abstract 15179: Long Term Prognosis of Intraventricular Conduction Delay in Patients With Structurally Normal Heart
Authors: Jae-Sun Uhm, Hee-Sun Mun, Tae-Hoon Kim, Hancheol Lee, Junbeom Park, Jin-Kyu Park, Nam-Kyun Kim, Boyoung Joung, Hui-Nam Pak, Moon-Hyoung Lee
Journal: Circulation (2014)

Introduction: Long-term prognosis of nonspecific intraventricular conduction delay(IVCD) remains unclear. This study was performed to elucidate long-term prognosis of IVCD in structurally normal heart. Hypothesis: Long-term prognosis of patients with IVCD in structurally normal heart would be poorer than patients without IVCD. Methods: Between 2000 and 2005, we evaluated the patients who underwent 12-lead electrocardiography. IVCD was defined QRS >110ms without the criteria of complete or incomplete bundle-branch block. The patients were excluded if they had structural heart diseases, such as myocardial infarction, valvular heart disease, congenital heart disease and cardiomyopathy. In a matched-cohort design, 353 patients (IVCD group) (male 83.9% with a mean age of 52.2±13.3 years) were matched for age and sex with 1060 patients (no IVCD group) who had neither IVCD nor structural heart diseases. Results: During the follow-up of 6.9 ± 3.2 years, the cumulative incidence rates of complete atrioventricular ...
Abstract 229: Differences in Utilization of Postarrest Care Based on Initial Rhythm
Authors: Anne V Grossestreuer, Sarah M Perman, Benjamin S Abella, Douglas J Wiebe, Marion Leary, Barry D Fuchs, David F Gaieski
Journal: Circulation (2014)

Background: Care of successfully resuscitated patients is highly variable. Whether initial rhythm is associated with receiving specific post-arrest interventions has not been explored. Objectives: Determine which specific post-arrest interventions are used in patients who remain comatose after resuscitation and whether use is associated with initial arrest rhythm. Methods: We included comatose post-arrest patients at 27 hospitals between 2000-2014. We examined patient and arrest characteristics and the use of specialist consultations, cardiac catheterization (cath) and electrophysiology (EP) assessments and interventions, targeted temperature management (TTM), EEG monitoring, head CT and MRI scans, echocardiography, withdrawal of life sustaining therapy (WLST) and length of stay, stratified on initial rhythm. Results: A retrospective cohort of 1923 patients was 57% male with a mean age of 62±16 yrs. Of 645 (34%) pts with a shockable initial rhythm, 51% survived to hospital discharge, 89% discharged with CPC 1-2. Of 1278 (66%) pts with a non-shockable initial rhythm, 26% survived to hospital discharge, 73% discharged with CPC 1-2. Patients with initial shockable rhythms were significantly (p&lt;0.05) more likely to have cardiology consults, EEGs, brain MRI scans, echocardiography, TTM, ICDs placed, cath and EP lab visits, longer hospital stays, and not to have WLST than patients with initial non-shockable rhythms. Controlling for cardiac etiology and TTM in logistic regression, cardiology consults, cath and EP lab visits, ICD placement, brain MRIs, echocardiography, and WLST remained significantly different between patients based on initial rhythm (Table 1). Conclusions: Post-arrest care varies between patients and can be influenced by arrest characteristics, such as initial pulseless rhythm. Patients with shockable rhythms are more likely to receive certain post-arrest interventions and testing than patients with non-shockable rhythms.
Drug points: Respiratory distress and royal jelly
Authors: S PEACOCK, V MURRAY, C TURTON
Journal: BMJ (1995)

write: We report a case of life threatening respiratory distress following the ingestion of royal jelly capsules.

A 31 year old non-smoking woman with a 15 year history of mild asthma used a salbutamol inhaler for occasional wheezing, had a normal exercise tolerance, and had not required hospital treatment. She presented to the casualty department with severe respiratory distress 40 minutes after ingesting two royal jelly capsules, although a …
Medical academic staffs conference Senior staffs conference GP non-principals have special education needs BMA's ARM agenda
Authors: Linda Beecham
Journal: BMJ (1998)

# Medical academic staffs conference {#article-title-2}

Medical academic staff have called for the research assessment exercise (RAE) to be fairer and more representative. At their annual conference last week the representatives declared that the use of impact factors was a totally inappropriate method of assessing medical research and called on the BMA to examine fairer alternative methods.

The RAE takes place every four years, and its aim is to measure the quality of research across all higher education and determine central funding for academic units in Britain. The assessment is based on peer review, including examination of published research and information about numbers of research students and research income during the assessment period.

The Medical Academic Staff Committee has criticised the exercise since its inception because of emphasis on research at the expense of teaching and service work. The 1997 Dearing report into higher education recommended a review of the exercise and the Higher Education Funding Council for England has set up a task force.

### Unscientific and unjust

Last week's meeting wholeheartedly endorsed Professor Gareth Williams's forthright account of why he believes the RAE is unscientific and unjust. Professor Williams, professor of medicine at the University of Liverpool, published his views in April (4 April, pp 1079-82).

He told the conference that the RAE had acquired such a momentum that it was almost impossible to stop. He said that it was wasteful of time and money; the data were misleading and unscientific; and the conclusions were biased and unjust. It ignored people who were not funded by the higher education funding councils and ignored total published output. There was potential for abuse—for example, a researcher's publications at one unit are transferred with the researcher to a new post and staff funded by councils were used to submit publications from ineligible researchers. Professor Williams said that the system was totally …
Abstract P054: The CUORE Project: The Predictive Role Of Cardiovascular Risk Factors Among Elderly Persons
Authors: Luigi Palmieri, Chiara Donfrancesco, Diego Vanuzzo, Marco M Ferrario, Salvatore Panico, Giancarlo Cesana, Francesco Dima, Lorenza Pilotto, Giovanni Veronesi, Amalia Mattiello, Simona Giampaoli
Journal: Circulation (2014)

Background: The number of elderly persons with cardiovascular disease (CVD) is rapidly increasing, mainly due to worldwide aging population. All CVD risk scores consider age as risk factor but most of them assume that the etiological role of other established risk factors is similar at all ages. This analyses aimed to assess the predictive role of cardiovascular risk factors in elderly persons. Methods: We considered 10,979 men and 16,533 women aged 35-74 years from cohorts in North, Centre and South of Italy with 10 years median follow-up time for fatal and non fatal coronary and cerebrovascular events (819 in men and 467 in women) validated according to MONICA criteria. In all cohorts risk factors were assessed by using standardized procedures. Two age groups were defined: adult 35-54 years of age (6,353 men and 10,358 women) and elderly 55-74 years (4,626 men and 6,175 men). Cox models were implemented including age, systolic blood pressure (SBP), total (TC) and HDL cholesterol (HDL-C), smoking, diabetes (DM - fasting blood glucose &gt;=126 mg/dl or under glucose treatment) and hypertension treatment (HT). For continuous variables, hazard ratios (HR) were reported at 1 standard deviation higher level and for dichotomized variables, yes vs no. Results: For adult men SBP resulted having a stronger impact on CVD risk than for elderly even if not statistically significant: adult HR 1.32, 95% confidence interval 1.18-1.48, vs elderly HR 1.25, 1.15-1.36; similar results for TC (HR 1.47 vs 1.25), smoking (HR 1.91, vs 1.52), DM (HR 1.76 vs 1.56), HT (HR 2.30 vs 1.25). HDL-C resulted not significantly associated with CVD risk in elderly men. Among adult women a stronger impact was found than in elderly for SBP (HR 1.59 vs 1.26), HDL-C (0.65 vs 0.84), smoking (2.43 vs 1.99), and HT (2.34 vs 1.45); the opposite for TC (1.19 vs 1.27). DM resulted not significantly associated with CVD risk in adult women. Age resulted having a stronger impact in elderly persons both in men and women (HR 1.22, 1.07-1.39, vs 1.44, 1.29-1.61; 1.45, 1.17-1.80, vs 1.63, 1.42-1.86 respectively). Conclusions: SBP and HT resulted having a pronounced lower impact on CVD risk in elderly than in adult as well as HDL-C for men; age shows a stronger impact in elderly than in adult. Further analyses are recommended to study the reliability of risk scores based on age-specific risk models, evaluating the introduction of different risk factors and considering survival probability derived from data in elderly population.
Computerized restriction endonuclease analysis compared with O-serotype and phage type in the epidemiologic fingerprinting of Pseudomonas aeruginosa strains
Authors: Javier Garaizar, Mikel Latorre, Nuria López-Molina, Idoia Laconcha, Leire Alberdi, Aitor Rementeria, Ana Audicana, Rosario Uliarte, Ramó Cisterna
Journal: Clinical Microbiology and Infection (1997)