tbuckley/cabot-search huggingface dataset:
DRUG THERAPY OF CEREBELLAR ATAXIA AND DISORDERS OF THE BASAL GANGLIA, BASED ON CEREBELLAR-STRIATAL ANTAGONISM
Authors: H KABAT
Journal: Annals of Internal Medicine (1959)

Article1 June 1959DRUG THERAPY OF CEREBELLAR ATAXIA AND DISORDERS OF THE BASAL GANGLIA, BASED ON CEREBELLAR-STRIATAL ANTAGONISMHERMAN KABAT, M.D., Ph.D.HERMAN KABAT, M.D., Ph.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-50-6-1438 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptIn an earlier paper1it was reported that patients with cerebellar ataxia and intention tremor show deficiency of voluntary isometric (holding) contraction of the skeletal muscles, whereas voluntary isotonic (active motion) contraction is relatively unaffected. Testing against manual resistance reveals greater power and endurance in isotonic contraction than in isometric contraction of the same muscle or muscle group. This discrepancy between isometric and isotonic function in voluntary movement is greater the more severe the cerebellar asynergia. In unilateral cerebellar involvement, the predominance of isotonic over isometric contraction is found only on the side showing cerebellar signs. While all muscle groups...Bibliography1. Kabat H: Analysis and therapy of cerebellar ataxia and asynergia, Arch. Neurol. and Psychiat. 74: 375-382 (Oct.) 1955. CrossrefGoogle Scholar2. Bing R: Cerebellopallidal anisosthenia, Neurology 1: 10-17 (Jan.-Feb.) 1951. CrossrefMedlineGoogle Scholar3. GoodmanGilman LA: The pharmacological basis of therapeutics, 1941, The Macmillan Company, New York. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Providence, Rhode Island*Received for publication December 23, 1958.From the Miriam Hospital, Providence, Rhode Island, and the State of Rhode Island, Department of Social Welfare.Requests for reprints should be addressed to Herman Kabat, M.D., Miriam Hospital, 164 Summit Avenue, Providence 6, Rhode Island. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byPseudoparkinsonism: A review of a common nonparkinsonian hypokinetic movement disorderPhenothiazine BibliographiesPharmacological Aspects of ParkinsonismPhenothiazine und Azaphenothiazine als HeilmittelThe Late Clinical Syndrome of Posticteric Encephalopathy 1 June 1959Volume 50, Issue 6Page: 1438-1448KeywordsAtaxiaDrug therapyGangliaIsotonicityMusclesSkeletal musclesSocial welfare ePublished: 1 December 2008 Issue Published: 1 June 1959 PDF downloadLoading ...
A Review of Progress in the Study of the Genetics of Spontaneous Tumor Incidence
Authors: C. C. Little
Journal: JNCI Journal of the National Cancer Institute (1941)

A Review of Progress in the Study of the Genetics of Spontaneous Tumor Incidence Get access C. C. Little C. C. Little Director Roscoe B. Jackson Memorial Laboratory, Bar Harbor, Maine Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 1, Issue 6, June 1941, Pages 727–736, https://doi.org/10.1093/jnci/1.6.727 Published: 01 June 1941
Prevalence of solar damage and actinic keratosis in a Merseyside population
Authors: A.A. Memon, J.A. Tomenson, J. Bothwell, P.S. Friedmann
Journal: British Journal of Dermatology (2000)

This study examines the prevalence of sun-related damage to the skin in a caucasian population in north-west England. The importance of constitutional factors (complexion, skin type and age) as well as environmental and occupational exposures for the development of actinic keratosis (AK) and skin cancers was assessed in people over 40 years of age attending outpatient clinics (non-dermatology) at four centres in north-west England (Mersey region). Nine hundred and sixty-eight volunteers (531 men and 437 women) were recruited. The overall prevalence of AK was 15.4% in men and 5.9% in women. The prevalence was strongly related to age in both sexes, being 34.1% and 18.2%, respectively, in men and women aged 70 years and above, and was most strongly related to two objective signs of sun exposure, namely degree of solar elastosis and presence of solar lentigines. The prevalence of AK was higher in subjects with red hair and freckles, particularly women. There was no evidence of an increased prevalence of AK in relation to any occupation. There was a high prevalence of seborrhoeic keratosis and viral warts in both sexes, which was age-related in the case of seborrhoeic keratosis. Ten cases of basal cell carcinoma, eight cases of Bowen's disease and one case of malignant melanoma were identified. This study shows that the sun exposure received in 'normal' life in England is sufficient to cause potentially malignant skin damage in a significant proportion of the population.
Abstract P328: Effects of Subclinical Disease on Cognitive Function across Age in African Americans
Authors: John M Bridges, Michael E Griswold, Brittany N Simpson, Patricia A Peyser, Lawrence F Bielak, Stephen T Turner, Seth T Lirette, Thomas H Mosley, B Gwen Windham
Journal: Circulation (2014)

Objectives: Determine relationships between calcification and cognitive function. Background: Dementia affects over 5.4 million Americans; prevalence will quadruple in the next 50 years. Coronary artery calcification (CAC), a measure of subclinical atherosclerosis, may affect cognitive function through microvascular brain effects. Abdominal aortoiliac calcification (AAC) generally precedes CAC and may provide earlier risk determination. Effects of calcification on cognition have not been studied in African Americans (AA). Methods: The 2008-2011 GENOA CAC cohort consists of AA sibships (n=657, mean age 69 [range 40-98], 74% women, 82% hypertensive) enriched with hypertension from Jackson, MS with computed tomography (CT) Agatston calcification measures. Cognition was assessed in 4 domains: global cognitive function (Mini-Mental State Examination); processing speed (Digit Symbol Substitution and Trail Making A); memory (RAVLT and WAIS-III Incidental Learning); and executive function (Trail Making B). Relationships of cognition (standardized) and calcification (log base 2 scale accounting for skewness) were examined using linear regressions with GEE to account for sibship clustering, adjusting parsimoniously for age, sex, and education. Results: Doublings of CAC were significantly associated with poorer processing speed (ß=-0.049 [-0.072, -0.025] p=0.000) and executive function (ß=-0.037 [-0.070, -0.003] p=0.031) in younger subjects and with poorer global function (ß=-0.0648 [-0.096, -0.020] p=0.000), memory (ß=-0.034 [-0.060, -0.007] p=0.013), and processing speed (ß=-0.051 [-0.076, -0.025] p=0.000) in older subjects. Doublings of AAC were significantly associated with poorer processing speed (ß=-0.0381 [-0.056, -0.020] p=0.000) and executive function (ß=-0.045 [-0.070, -0.020] p=0.000) in younger subjects and poorer processing speed (ß=-0.050 [-0.075, -0.025] p=0.000) in older subjects. Conclusions: Calcification is associated with processing speed in young and old AA with prevalent cardiovascular risk factors and may be differentially associated with other cognitive domains by age. Processing speed in particular may be a domain affected early in the calcification process, warranting further study. This supports existing literature addressing the relationship between calcification and cognitive function in ethnically diverse cohorts. Further studies can focus on the temporal and causal relationships between calcification and cognition across age in AA samples enriched for hypertension to identify predictive factors associated with future cognitive decline.
Abstract 706: A novel photodynamic therapy with virus-mediated delivery of photosensitive cytotoxic fluorescent protein KillerRed for human cancers
Authors: Kiyoto Takehara, Hiroshi Tazawa, Yuuri Hashimoto, Hiroyuki Kishimoto, Toshiyoshi Fujiwara, Nobuhiro Narii, Hiroyuki Mizuguchi
Journal: Cancer Research (2014)

Abstract Photodynamic therapy (PDT) is an antitumor strategy to induce tumor-specific cytotoxicity through accumulation of photosensitizers (PSs) and following light irradiation. Specific wavelength light irradiation induces the PS-mediated generation of reactive oxygen species (ROS) and subsequent cytotoxicity in tumor cells. Currently, some kinds of PSs, such as photofrin and laserphyrin, are used for PDT on clinical settings. However, the lack of sufficient and continuous accumulation of PSs in tumor tissues makes difficult to eradicate tumor cells by PDT. Therefore, the development of novel strategy for accumulation of PS in tumor tissues more efficiently and persistently is required to improve the antitumor effect of PDT. A bioengineered fluorescent protein KillerRed has been previously reported to generate ROS upon green light irradiation, suggesting a potential of KillerRed fluorescent protein as a novel PS. We recently confirmed that transient or stable transfection with KillerRed-expressing plasmid vector suppressed the cell viability through induction of ROS-mediated apoptosis in various types of human cancer cells when combined with light irradiation. In this study, we generated non-replicative adenovirus expressing KillerRed (Ad-KillerRed) and telomerase-specific conditionally replicating adenovirus expressing KillerRed (CRAd-KillerRed) to induce efficient accumulation of KillerRed in tumor cells. The in vitro antitumor effect of these viruses was investigated in human cancer H1299, HCT116 and HT29 cells in combination with light irradiation. Ad-KillerRed at high dose suppressed cell viability of human cancer cells when combined with light irradiation. In contrast, CRAd-KillerRed suppressed cell viability of human cancer cells more efficiently compared to Ad-KillerRed in combination with light irradiation. These results suggest that virus-mediated delivery system of KillerRed is a promising strategy for novel PDT. Now, in vivo experiments are under way to investigate antitumor effect of these viruses. Citation Format: Kiyoto Takehara, Hiroshi Tazawa, Yuuri Hashimoto, Hiroyuki Kishimoto, Toshiyoshi Fujiwara, Nobuhiro Narii, Hiroyuki Mizuguchi. A novel photodynamic therapy with virus-mediated delivery of photosensitive cytotoxic fluorescent protein KillerRed for human cancers. [abstract]. In: Proceedings of the 105th Annual Meeting of the American Association for Cancer Research; 2014 Apr 5-9; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2014;74(19 Suppl):Abstract nr 706. doi:10.1158/1538-7445.AM2014-706
Comment on Inzucchi et al. Management of Hyperglycemia in Type 2 Diabetes, 2015: A Patient-Centered Approach. Update to a Position Statement of the American Diabetes Association and the European Association for the Study of Diabetes. Diabetes Care 2015;38:140–149
Authors: Gijs W.D. Landman, Nanne Kleefstra, Sebastiaan T. Houweling
Journal: Diabetes Care (2015)

The American Diabetes Association (ADA) and the European Association for the Study of Diabetes (EASD) convened a joint task force that examined the evidence on blood glucose–lowering therapy in adults with type 2 diabetes and published a position statement (1). Recently, these recommendations were updated and published in the January 2015 issue of the journal (2).

The ADA/EASD recommendations are postulated as being …
Alternatives to Hazard Ratios for Comparing the Efficacy or Safety of Therapies in Noninferiority Studies
Authors: Hajime Uno, Janet Wittes, Haoda Fu, Scott D. Solomon, Brian Claggett, Lu Tian, Tianxi Cai, Marc A. Pfeffer, Scott R. Evans, Lee-Jen Wei
Journal: Annals of Internal Medicine (2015)

A noninferiority study is often used to investigate whether a treatment's efficacy or safety profile is acceptable compared with an alternative therapy regarding the time to a clinical event. The empirical quantification of the treatment difference for such a study is routinely based on the hazard ratio (HR) estimate. The HR, which is not a relative risk, may be difficult to interpret clinically, especially when the underlying proportional hazards assumption is violated. The precision of the HR estimate depends primarily on the number of observed events but not directly on exposure times or sample size of the study population. If the event rate is low, the study may require an impractically large number of events to ensure that the prespecified noninferiority criterion for the HR is attainable. This article discusses deficiencies in the current approach for the design and analysis of a noninferiority study. Alternative procedures are provided, which do not depend on any model assumption, to compare 2 treatments. For a noninferiority safety study, the patients' exposure times are more clinically important than the observed number of events. If the patients' exposure times are long enough to evaluate safety reliably, then these alternative procedures can effectively provide clinically interpretable evidence on safety, even with relatively few observed events. These procedures are illustrated with data from 2 studies. One explores the cardiovascular safety of a pain medicine; the second examines the cardiovascular safety of a new treatment for diabetes. These alternative strategies to evaluate safety or efficacy of an intervention lead to more meaningful interpretations of the analysis results than the conventional strategy that uses the HR estimate.
Incidence of invasive fungal disease after unmanipulated haploidentical stem cell transplantation was significantly higher than that after HLA-matched sibling transplantation
Authors: Y. Sun, L. Xu, D. Liu, X. Zhang, W. Han, Y. Wang, H. Chen, Y. Chen, F. Wang, J. Wang, Y. Ji, F. Tang, K. Liu, X.-J. Huang
Journal: Clinical Microbiology and Infection (2012)
Folic Acid in Endothelial Function in Familial Hypercholesterolemia
Authors: M. F. Bellamy, I. F. W. McDowell, M. J. Lewis
Journal: Circulation (2000)

To the Editor:Verhaar and colleagues, in their recent article, 1 report on improvement in forearm endothelial function after 4 weeks' oral treatment with folic acid at a dose of 5 mg daily in 20 subjects.They used a randomized crossover design without an intervening washout period.Our research group conducted a similar randomized crossover study of folate supplementation in healthy subjects with hyperhomocysteinemia 2 in which 18 subjects received oral folic acid 5 mg daily for a slightly longer period of 6 weeks.We included a washout period of 6 weeks between treatments, but despite this, there was a considerable carryover effect in those subjects who received folic acid before placebo.This was not surprising considering the high dose of folic acid used and the fact that folic acid is stored in red blood cells, which have a life span of Ϸ120 days.Such carryover effects in trials involving the use of folic acid have important implications in the interpretation of results and in the design of such studies.
Abstract 3401: Cell Therapy For Idiophatic Dilated Cardiomyopathy
Authors: Antonio C Campos de Carvalho, Helena F Martino, Paulo S Oliveira, Edmilson Assunção, Rita Vilela, Miriam Gaze, Fernando C Souza, Patricia C Costa, Fabiana Muccillo, Luis H Weitzel, Sophie Arvello, Amarino Oliveira
Journal: Circulation (2007)

Given the limited therapeutic options for refractory dilated cardiomyopathy we decided to perform a phase I clinical trial using bone marrow derived mononuclear cells in patients with functional classes II and IV of the NYHA. Inclusion criteria required EF% (Simpson) &lt;35%, VO2 max &lt; 16 kg.ml /min and signed informed consent. After enrollment patients were subject to the following exams at baseline, 2 and 6 months after cell therapy: 12 lead ECG and 24hs holter, echocardiography, chest X-ray, blood biochemistry, BNP, ergoespirometry, MRI and Minnesota Questionnaire. Patients were subject to bone marrow aspiration (80–100 mL) under sedation and local anesthesia and mononuclear cells were obtained after Ficoll gradient centrifugation. A mean of 198 million cells diluted in 20 ml of saline were slowly delivered through catheterization in the coronary arteries (10 ml in LAD, 5 ml in RC, 5 ml in CX). After the procedure patients remained hospitalized for 48hs. We report the results of the first 22 patients that completed the follow-up period. No adverse effects related to the procedure were observed, nor were arrhythmias detected after cell delivery. Four patients died during follow up. For the 18 patients that completed follow up, there was a significant improvement in NYHA functional class and quality of life at 2 and 6 months (p&lt;0.03 and p&lt; 0.007, respectively). There were no statistically significant changes in EF% (18.6%, 18.6% and 19%), EDV (360, 371, 386 ml) or ESV (295, 308, 314 ml) at baseline, 2 and 6 months respectively as measured by MRI. Maximal oxygen consumption showed as significant increase after cell therapy (12.5, 15.3, 16.8 ml/kg.min), and the number of patients with oxygen consumption below the threshold for cardiac transplantation decrease from 75% at baseline to 25% six months after cell therapy. BNP levels were not significantly altered (650, 475, 530 pg/ml). When observed individually, 4 of the 17 patients examined showed an increase in EF% by MRI ≥5%, 7 did not change EF% and 3 decreased EF% by ≥5%. In conclusion, the procedure is safe and feasible but further studies are necessary to test for efficacy.
Pneumococcal Vaccination in Adults—Reply
Authors: Katherine A. Robinson
Journal: JAMA (2001)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Final Guidance Issued on Abuse-Deterrent Opioids
Authors: Rita Rubin
Journal: JAMA (2015)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
TESTING FOR ANTIBIOTIC SENSITIVITY IN A GENERAL HOSPITAL
Authors: A J WEIL, L HARRIS
Journal: Annals of Internal Medicine (1953)

ExcerptExperimental data and clinical experience have produced rules which direct the choice of antibiotic agents in daily practice. Most of the work on which these rules are based was obtained from "virgin" material, virgin in the sense that the microörganisms studied had not previously been exposed to antibiotics. The wide use of these agents has created a different situation. An organism that was originally susceptible may be replaced by resistant mutants in the individual case and eventually throughout its habitat. Perhaps the best known example of this change is that of the susceptibility ofStaphylococcus aureusto penicillin, which has...
Toldt: Anatomischer Atlas für Studierende und Ärzte.
Authors: Carl Toldt, Ferdinand Hochstetter
Journal: JAMA (1927)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal