tbuckley/cabot-search huggingface dataset:
Abstract P224: The Haptoglobin (Hp) Genotype Predicts Coronary Artery Disease (CAD) During 25 Years of Follow-up in Type 1 Diabetes: Potential Pole of Impaired HDL Cholesterol Efflux Capacity
Authors: Tina Costacou, Jay W Heinecke, Tomas Vaisar, Trevor J Orchard
Journal: Circulation (2015)

Background: The Hp 2-2 genotype has been associated with increased cardiovascular risk in type 2 diabetes, potentially relating to dysfunctional HDL mediated cholesterol efflux. We have shown that the Hp 2 allele predicts the development of both coronary artery disease (CAD) and kidney dysfunction also in childhood onset type 1 diabetes over 18 years of follow-up in the Epidemiology of Diabetes Complications (EDC) study. We now present results on the Hp-CAD association after an additional 7 year follow-up and Hp’s relation to impaired sterol efflux capacity, a proposed cardioprotective effect of HDL. Methods: Participants free of CAD at baseline and with Hp determined were studied (n=565; mean age, 27 and duration, 19 years; 11.5% Hp 1-1, 42.5% Hp 2-2). CAD was defined as EDC physician diagnosed angina, ischemic ECG changes (MC 1.3, 4.1-4.3, 5.1-5.3, 7.1), confirmed MI (MC 1.1, 1.2 or validated medical records), stenosis &gt;50%, revascularization or CAD death. In a pilot study, serum HDL sterol efflux was assessed in Mifepristone stimulated ABCA1-BHK cells among 20 individuals (6 Hp 1-1; 7 Hp 2-1; 7 Hp 2-2) attending the 25 year exam. Results: During follow-up, 186 (32.9%) developed CAD. Incidence increased with the number of Hp 2 alleles (24.6% in Hp 1-1, 31.1% in Hp 2-1 and 37.1% in Hp 2-2, p-trend=0.04; Fig. 1). Multivariably, Hp 2-2 significantly increased risk by almost 80% (HR=1.79, 1.03-3.09). The risk associated with Hp 2-1 did not reach significance (HR=1.46, 0.85-2.53). In the pilot study, serum HDL sterol efflux was lower in Hp 2 allele carriers: 14.0% in Hp 1-1, 12.5% in Hp 2-1, 12.4% in Hp 2-2, p-trend=0.06, p-value Hp 1-1 vs Hp 2-1/2-2 =0.04. Conclusion: These results extend our previous findings of increased CAD risk associated with the Hp 2 allele in type 1 diabetes and further suggest that this allele associates with impaired sterol efflux capacity. These results support the hypothesis that sterol efflux explains the increased Hp 2 risk for CAD and should be confirmed prospectively. Figure 1. CAD-free survival curves by Hp genotype
IDIOPATHIC ORGANO-AXIAL VOLVULUS OF THE STOMACH: CASE REPORT
Authors: I I LASKY, I L LICHTENSTEIN
Journal: Annals of Internal Medicine (1956)

Excerpt In 1866 there appeared in the literature for the first time a report of recurrent gastric volvulus; Berti1described a forward, upward rotation of the stomach, traversing an arc of 180 degre...
117. Antitumor Immunity Induced by Adenovirus Vector-Mediated Transduction of OX40 Ligand
Authors: Joshua J. Short, Alexander V. Pereboev, Yosuke Kawakami, Chenthamarakshan Vasu, Mark J. Holterman, David T. Curiel
Journal: Molecular Therapy (2004)

As the field of Adenovirus (Ad) gene therapy continues to develop, alternate serotypes have been explored as a means to circumvent the disadvantages of Ad serotype 5 (Ad5)-based vectors. One such group of alternate serotypes that has been intensively investigated is the Ad subgroup B. Members of the Ad subgroup B have been found to efficiently transduce cells of the hematopoeitic system as well as more efficiently transduce malignant cells in a variety of neoplastic contexts compared to Ad5-based vectors. Whereas the majority of human Ad utilize the Coxsackie and Adenovirus Receptor (CAR) to infect cells, none of the Ad subgroup B utilize CAR. It has previously been demonstrated that Ad subgroup B, which are further divided into two groups: B1 and B2, utilize at least two distinct receptors. In this regard, CD46 has been implicated as the B2-specific receptor. Recently, Ad serotype 3 (Ad3), a member of Ad subgroup B1, was found able to utilize CD80 and CD86 as a primary cellular attachment receptors on human dendritic cells and the cervical carcinoma cell line HeLa. CD80 and CD86 are cell surface markers expressed on human dendritic cells and mature B-lymphocytes, and play a critical role in stimulating T-lymphocyte responses by their interaction with the ligands CD28 and CTLA-4. Both CD80 and CD86 are upregulated during the process of dendritic cell maturation and are often over-expressed in a variety of lymphocytic neoplasms and other neoplastic contexts. Whereas, CD80 and CD86 serve as the primary receptor for Ad3 on human dendritic cells, they play a more secondary role in HeLa infection. There exists a close homology between the knob domains of the Ad fiber, the receptor-interacting protein of the virion, of several members of subgroup B Ad. On this basis, we hypothesized that other members of the Ad subgroup B may utilize CD80 and CD86 as primary cellular attachment receptors. Recombinant knob domain of the Ad fiber from both B1 and B2 Ad could efficiently block CD80 and CD86-dependent infection of Ad3 vectors. All subgroup B members showed specific binding to cells expressing CD80 and CD86. Members of both B1 and B2 demonstrated CD80 and CD86-specific infection of CHO cells heterogenously expressing CD80 and CD86. Therefore, it appears that all of the members of Ad subgroup B can utilize CD80 and CD86 for infection of cells. Though these may not represent the only primary cellular receptors utilized by these viruses on all cells in the case of Ad3 they appear to play a critical role in the infection of human dendritic cells. This finding may help facilitate the construction of Ad subgroup B based vectors in the application of vaccine development and for vectors targeted towards CD80 and CD86 expressing neoplasms.
Abstract 15040: Long Term Outcomes After Transcatheter and Surgerical Closure of Atrial Setpal Defect: Implications From National Populational Based Cohort Study in Propensity Score Matching
Authors: Tien Hsing Chen, Yung Chuan Hsiao, Chia Chi Cheng
Journal: Circulation (2014)

Introduction:  Transcatheter and surgical closure of atrial septal defect were both standard treatment. However, no randomized controlled trial performed compared them directly.   Hypothesis:  Surgical closure of atrial septal defect could have worse outcome because surgical wound and anesthesia.   Methods:  We enrolled 26,605 patients with atrial septal defect from 2004 to 2011. Inclusion criteria is patient received transcatheter or surgical closure for significant hemodynamic changed atrial septal defect and age is more than 18 years-old. Exclusion criteria were patients with heart failure, pulmonary hypertension, any valve disease and any other congenital heart disease.   Results:  There were 510 patients more than 18 year-old have transcatheter and surgical correction, respectively. Compared with two groups, there were higher risk of ischemic stroke (HR=4.72, P=0.006), systemic thromboembolism (HR=5.31, P=0.003), atrial fibrillation (HR=1.69, P=0.048), heart failure (HR=2.30, P   Conclusions:  Patients received transcatheter intervention for significant hemodynamic changed atrial septal defect have favorable outcomes than surgical closure.
Abstract 2668: Downregulation of Myocardial Connexin43 and Arrythmogenesis After Injection of Skeletal Myoblasts but not Bone Marrow Cells into the Failing Heart
Authors: Steven R Coppen, Satsuki Fukushima, Anabel Varela-Carver, Husein Salem, Kunihiko Takahashi, Magdi H Yacoub, Ken Suzuki
Journal: Circulation (2007)
Correspondence re: A. S. Lübbe et al., Preclinical Experiences with Magnetic Drug Targeting: Tolerance and Efficacy. Cancer Res., 56: 4694–4701, 1996; and Clinical Experiences with Magnetic Drug Targeting: A Phase I Study with 4′-Epidoxorubicin in 14 Patients with Advanced Solid Tumors. Cancer Res., 56: 4686–4693, 1996—Reply
Authors: Andreas S. Lübbe
Journal: Cancer Research (1997)
A Phase II Randomized Double-Masked Trial of Pegaptanib, an Anti–Vascular Endothelial Growth Factor Aptamer, for Diabetic Macular Edema
Authors: Emmett T Cunningham, Anthony P Adamis, Michael Altaweel, Lloyd P Aiello, Neil M Bressler, Donald J D'Amico, Mauro Goldbaum, David R Guyer, Barrett Katz, Manju Patel, Steven D Schwartz
Journal: Ophthalmology (2005)
Canada pushes for strong global tobacco treaty
Authors: Tudor Toma
Journal: BMJ (2000)

Canada is pushing for a strong global tobacco treaty that will serve as a legal instrument to stop the tobacco epidemic, Garfield Mahood, executive director of the Canadian-based Non-Smokers' Rights Association, told the American Thoracic Association Congress in Toronto last week.

The treaty, known as the Framework Convention on Tobacco Control, was initiated by the World Health Organization …
CT Signs of Right Ventricular Dysfunction
Authors: Doo Kyoung Kang, Christian Thilo, U. Joseph Schoepf, J. Michael Barraza, John W. Nance, Gorka Bastarrika, Joseph A. Abro, James G. Ravenel, Philip Costello, Samuel Z. Goldhaber
Journal: JACC. Cardiovascular imaging (2011)
Abstract 18320: Bedside Ultrasound Evaluation of Right Atrial Pressure to Predict Acute Decompensated Heart Failure 30-Day Readmission
Authors: Frederick G Schnatz, Sneha N Parikh, Jonathan E Leeman, Madhurmeet Singh, Flordeliza S Villanueva, Marc A Simon, John J Pacella
Journal: Circulation (2014)

Heart failure is one of the most costly diagnosis-related groups (DRG) in the U.S. with hospitalizations accounting for 60% of the total DRG cost. A large part of the morbidity and cost of heart failure are hospital readmissions. Due to this and recent health care laws penalizing hospitals for high readmission rates, there is a strong need for intervention. Objective assessment of volume status to ensure optimization prior to hospital discharge could significantly reduce readmissions. We have previously demonstrated a bedside ultrasound (US) method quantifying percent cross sectional area (CSA) change of the right internal jugular vein (RIJV) with Valsalva that reliably estimates central venous pressure. We hypothesize that bedside US measurement of the RIJV in acute decompensated heart failure (ADHF) patients at discharge is predictive of 30-day readmission. Patients admitted with ADHF to the heart failure service were enrolled. A portable US machine (Sonosite iLook25) equipped with a standard broadband linear array (10-5MHz) transducer was used to image the RIJV at end-expiration and during the strain phase of Valsalva. Valsalva was standardized by a manometric pressure of at least 40 mmHg during expiration against a closed glottis. Images were obtained at admission and discharge (n=157). A subgroup of patients underwent RHC with accompanying US measurements of the RIJV (n=76) demonstrating that a percent cross sectional area (CSA) change of
A major susceptibility locus for leprosy in India maps to chromosome 10p13
Authors: M. Ruby Siddiqui, Sarah Meisner, Kerrie Tosh, Karuppiah Balakrishnan, Satish Ghei, Simon E. Fisher, Marina Golding, Nallakandy P. Shanker Narayan, Thiagarajan Sitaraman, Utpal Sengupta, Ramasamy Pitchappan, Adrian V.S. Hill
Journal: Nature Genetics (2001)
5‐HT radioligands for human brain imaging with PET and SPECT
Authors: Louise M. Paterson, Birgitte R. Kornum, David J. Nutt, Victor W. Pike, Gitte M. Knudsen
Journal: Medicinal Research Reviews (2011)

The serotonergic system plays a key modulatory role in the brain and is the target for many drug treatments for brain disorders either through reuptake blockade or via interactions at the 14 subtypes of 5‐HT receptors. This review provides the history and current status of radioligands used for positron emission tomography (PET) and single photon emission computerized tomography (SPECT) imaging of human brain serotonin (5‐HT) receptors, the 5‐HT transporter (SERT), and 5‐HT synthesis rate. Currently available radioligands for in vivo brain imaging of the 5‐HT system in humans include antagonists for the 5‐HT 1A , 5‐HT 1B , 5‐HT 2A , and 5‐HT 4 receptors, and for SERT. Here we describe the evolution of these radioligands, along with the attempts made to develop radioligands for additional serotonergic targets. We describe the properties needed for a radioligand to become successful and the main caveats. The success of a PET or SPECT radioligand can ultimately be assessed by its frequency of use, its utility in humans, and the number of research sites using it relative to its invention date, and so these aspects are also covered. In conclusion, the development of PET and SPECT radioligands to image serotonergic targets is of high interest, and successful evaluation in humans is leading to invaluable insight into normal and abnormal brain function, emphasizing the need for continued development of both SPECT and PET radioligands for human brain imaging. © 2011 Wiley Periodicals, Inc.
The Wounded Foot
Authors: M. Therese Southgate
Journal: JAMA (2004)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Successful treatment of aphthous ulcerations in AIDS patients using topical granulocyte-macrophage colony-stimulating factor
Authors: P. Herranz, J.R. Arribas, A. Navarro, J.M. Peña, J. González, F.A. Rubio, M. Casado
Journal: British Journal of Dermatology (2000)

Oral recurrent aphthous ulceration (RAU) is a well-recognized complication in patients infected with human immunodeficiency virus. RAU can be progressive and destructive, causing dysphagia and secondary malnutrition. The aetiology of RAU remains unknown, and its response to available treatments is often unsatisfactory. We describe three patients with advanced AIDS who suffered from extensive RAU which failed to respond to several treatments, including topical viscous lidocaine and topical and systemic glucocorticoids. Owing to difficulties in using thalidomide (two patients had neurological conditions which precluded thalidomide use), all three patients were treated with an oral solution containing recombinant human granulocyte-macrophage colony-stimulating factor (GM-CSF, 400 microg in 5% glucose 200 mL). From the first application, all three patients showed significant improvement of their lesions and amelioration of pain, and they were completely cured in a few days. No adverse effects were recorded. The patients did not show relapses of RAU over a prolonged follow-up. Controlled trials are warranted in order to establish the role of GM-CSF as a valid, alternative option for aphthous ulcerations of the mouth in AIDS patients in whom corticosteroids or thalidomide are not suitable.
Anesthesia and Sedation in the Dental Office
Authors: Raymond Dionne, Daniel M. Laskin
Journal: JAMA (1985)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
SOME CLINICAL CHARACTERISTICS OF MUMPS, AND THE EFFECT OF BELLADONNA IN TREATMENT; A STUDY MADE AT THE STATION HOSPITAL, FORT GEORGE G. MEADE, MARYLAND
Authors: Harold W. Potter, Lewis H. Bronstein
Journal: Annals of Internal Medicine (1944)

Article1 September 1944SOME CLINICAL CHARACTERISTICS OF MUMPS, AND THE EFFECT OF BELLADONNA IN TREATMENT; A STUDY MADE AT THE STATION HOSPITAL, FORT GEORGE G. MEADE, MARYLANDHAROLD W. POTTER, F.A.C.P., LEWIS H. BRONSTEINHAROLD W. POTTER, F.A.C.P.Search for more papers by this author, LEWIS H. BRONSTEINSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-21-3-469 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptIn civilian practice mumps is considered a disease of children and, therefore, is not considered much of a problem from the standpoint of disturbing the life of a community. The adults who contract the disease are usually the butt of jokes of their friends and are infrequent enough to cause comment only from that standpoint.In military life, however, mumps may become much more of a problem, not from a disabling standpoint, but from the fact that it might fill hospital beds which are needed for other types of sick patients. The length of time the soldier has to stay...Bibliography1. WESSELHOEFT C: Mumps: Its glandular and neurologic manifestations. Virus and rickettsial diseases, Harvard School of Public Health Symposium, 1940, 309-342. Google Scholar2. GORDONHEEREN JERH: Epidemiology of mumps, Am. Jr. Med. Sci., 1940, cc, 412-428. Google Scholar3. RAVDIN MJ: The epidemic of mumps at Camp Wheeler, Oct. 1917-March 1918, Arch. Int. Med., 1918, xxii, 354-369. CrossrefGoogle Scholar4. WHEELIS JM: A time study of morbidity and mortality in the United States Navy, Am. Jr. Pub. Health, 1938, xxviii, 1291-1297. CrossrefGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: *Received for publication August 16, 1943. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 September 1944Volume 21, Issue 3Page: 469-474KeywordsArmed forcesChildrenMumps ePublished: 1 December 2008 Issue Published: 1 September 1944 PDF downloadLoading ...
Heterogeneity of the genetic risk in age-related macular disease
Authors: Jacqueline J.M. Assink, Caroline C.W. Klaver, Jeanine J. Houwing-Duistermaat, Roger C.W. Wolfs, Cornelia M. van Duijn, Albert Hofman, Paulus T.V.M. de Jong
Journal: Ophthalmology (2005)
27. Differential Phage Display for Discovery of Nuclear Localization Peptides: Application to Mammary Adenocarcinoma
Authors: Ashley A. Weiner, Todd D. Giorgio
Journal: Molecular Therapy (2004)

This study reports the discovery of nuclear targeting ligands for normal and tumorigenic mammary epithelium via combinatorial phage display techniques. Molecular targeting to the nuclei of neoplastic cells using these new ligands represents a new and important tool in improving the therapeutic index of anticancer therapies.
Health Benefits of Breastfeeding Promotion—Reply
Authors: Michael S. Kramer
Journal: JAMA (2001)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Regulation of Respiration
Authors: Albert J. Berger, Robert A. Mitchell, John W. Severinghaus
Journal: New England Journal of Medicine (1977)

The major goal of this article is to provide an interpretative review of the respiratory control system. First, we discuss two of the three basic elements of this system: the sensors and the controller (Fig. 1). Then, we consider the system as a whole and discuss the integrated acute and chronic respiratory responses to various stimuli, including hypercapnia, hypoxemia, acid–base disturbances, acclimatization to altitude and response to exercise. We have concentrated upon presenting material published within the last six years.SensorsPeripheral ChemoreceptorsThe peripheral arterial chemoreceptors are responsible for the immediate increase in breathing produced by oxygen lack. These . . .
Emollient molecule effects on the drying stresses in human stratum corneum
Authors: K. Levi, A. Kwan, A.S. Rhines, M. Gorcea, D.J. Moore, R.H. Dauskardt
Journal: British Journal of Dermatology (2010)

Journal Article Emollient molecule effects on the drying stresses in human stratum corneum Get access K. Levi, K. Levi Department of Materials Science and Engineering, 496 Lomita Mall, Durand Building, Room 121, Stanford University, Stanford, CA 94305‐2205, U.S.A. Search for other works by this author on: Oxford Academic Google Scholar A. Kwan, A. Kwan Department of Materials Science and Engineering, 496 Lomita Mall, Durand Building, Room 121, Stanford University, Stanford, CA 94305‐2205, U.S.A. Search for other works by this author on: Oxford Academic Google Scholar A.S. Rhines, A.S. Rhines Department of Materials Science and Engineering, 496 Lomita Mall, Durand Building, Room 121, Stanford University, Stanford, CA 94305‐2205, U.S.A. Search for other works by this author on: Oxford Academic Google Scholar M. Gorcea, M. Gorcea International Specialty Products, Wayne, NJ, U.S.A. Search for other works by this author on: Oxford Academic Google Scholar D.J. Moore, D.J. Moore International Specialty Products, Wayne, NJ, U.S.A. Search for other works by this author on: Oxford Academic Google Scholar R.H. Dauskardt R.H. Dauskardt Department of Materials Science and Engineering, 496 Lomita Mall, Durand Building, Room 121, Stanford University, Stanford, CA 94305‐2205, U.S.A. Correspondence: Reinhold H. Dauskardt. E‐mail: dauskardt@stanford.edu Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 163, Issue 4, 1 October 2010, Pages 695–703, https://doi.org/10.1111/j.1365-2133.2010.09937.x Published: 01 October 2010