Treating Familial Mediterranean Fever with Prazosin Hydrochloride
Authors: Hideki Kataoka
Journal: Annals of Internal Medicine (1998)

Letters1 September 1998Treating Familial Mediterranean Fever with Prazosin HydrochlorideHideki Kataoka, MD, Hiromichi Kumagai, MD, and Hiroyuki Hanai, MDHideki Kataoka, MDHamamatsu University School of Medicine; Hamamatsu, JapanSearch for more papers by this author, Hiromichi Kumagai, MDHamamatsu University School of Medicine; Hamamatsu, JapanSearch for more papers by this author, and Hiroyuki Hanai, MDHamamatsu University School of Medicine; Hamamatsu, JapanSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-129-5-199809010-00022 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:The cause of familial Mediterranean fever (FMF), a recurrent polyserositis, has long been controversial. Recent studies [1, 2] have shown that intravenous administration of metaraminol can provoke FMF, whereas reserpine can suppress such symptoms as fever and abdominal pain [3]. This evidence suggests that abnormal catecholamine metabolism could play a role in the pathogenesis of FMF. On the basis of these facts, we tested the effectiveness of the α-adrenergic receptor antagonist prazosin hydrochloride for preventing attacks of FMF.A 36-year-old Japanese man who had had self-limited recurrent chest and abdominal pain and high fever every 1 to ...References1. Barakat MH, El-Khawad AO, Gumaa KA, El-Sobki NI, Fenech FF. Metaraminol provocative test: a specific diagnostic test for familial Mediterranean fever. Lancet. 1984; 1:656-7. Google Scholar2. Barakat MH, El-Sobki NI, El-Khawad AO, Gumaa KA, Fenech FF. Diagnosing familial Mediterranean fever. Lancet. 1984; 1:41-2. Google Scholar3. Hayashi A, Suzuki T, Shimizu A, Yamamura Y. Periodic fever suppressed by reserpine [Letter]. Lancet. 1976; 1:592. Google Scholar4. Goldfinger SE. Colchicine for familial Mediterranean fever [Letter]. N Engl J Med. 1972; 287:1302. Google Scholar5. Zemer D, Pras M, Sohar E, Modan M, Cabili S, Gafni J. Colchicine in the prevention and treatment of the amyloidosis of familial Mediterranean fever. N Engl J Med. 1986; 314:1001-5. Google Scholar Author, Article, and Disclosure InformationAffiliations: Hamamatsu University School of Medicine; Hamamatsu, Japan PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byTreatment of Colchicine-Resistant Familial Mediterranean Fever With AnakinraClinical and Genetic Features of Familial Mediterranean Fever in JapanGenetics and New Treatment Modalities for Familial Mediterranean FeverSuccessful Treatment with Infliximab and Low-dose Methotrexate in a Japanese Patient with Familial Mediterranean FeverClinical Study of 7 Cases of Familial MediterraneanFever with MEFV Gene MutationHereditary Periodic Fever Syndromes in JapanA Japanese Patient with Familial Mediterranean Fever Associated with Compound Heterozygosity for Pyrin Variant E148Q/M694IHereditary Periodic FeverPROGRESSIVE BOUTS OF ACUTE ABDOMEN: PET THE PERITONEUM 1 September 1998Volume 129, Issue 5Page: 424-425KeywordsAbdominal painCardiovascular therapyCatecholaminesColchicineFeversHypotensionPathogenesisReserpineTemperatureThorax ePublished: 15 August 2000 Issue Published: 1 September 1998 Copyright & PermissionsCopyright © 1998 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...