tbuckley/cabot-search huggingface dataset:
THE FOLLOW-UP OF DISCHARGED MENTAL PATIENTS BY THE PUBLIC HEALTH NURSE
Authors: FLORENCE A. BEASLEY, CLAIRE S. CALLAWAY, TRAWICK H. STUBBS
Journal: American Journal of Psychiatry (1960)

The Georgia Department of Public Health, in cooperation with the Milledgeville State Hospital,4 initiated a program of supportive services by public health nurses to mental hospital patients and their families in January, 1953. This program was not limited to the discharged patient, but included the patient and family at the time of commitment, during the patient's hospitalization, and after discharge to the community. At the end of 2 years as a pilot project, the program was evaluated and this activity included as a part of the generalized public health nursing program state-wide. It is now operating in 49 of the state's 159 counties. A second program is presently being developed as a part of a state-aid program for intensive treatment of mentally ill patients in general hospitals. Essentially the same kinds of supportive services are offered to patients and families by the public health nurses. These programs are ways of applying the current theoretical emphasis that emotional illness involves not just individuals, but situations and relationships in families and communities. As modern public health programs seek to deal seriously with the problem of mental illness, a balance must be maintained between services to the sick and preventive and health promoting activities for total populations. The present program of the Georgia Department of Public Health, overlapping both areas, offers opportunity for continuing development of public health programs on a sound basis of experience which bridges gaps between hospital and community. The development of newer programs and the involvement of public health nurses in a broader scope of health services raises many questions for those interested in the preparation of future public health nurses as well as the continuing education of those currently employed. We believe this type program, modified to fit the special situation in each state, will be an important element in the total resources for offering follow-up services to the mentally ill.
Effects of brain death and glucose infusion on hepatic glycogen and blood hormones in the pig
Authors: K Roelsgaard, H E Bøtker, H Stødkilde-Jørgensen, F Andreasen, S L Jensen, S Keiding
Journal: Hepatology (1996)

We wished to study the effects of intravenous glucose/ insulin infusion to brain–dead pigs on the hepatic glycogen content. Four groups of 40– kg pigs were studied: brain–dead and control pigs given isotonic saline or glucose/insulin (7.5 mg glucose/kg/min, 1.25 mU insulin/kg/ min) (n = 5 to 10 in each group). Brain death was induced by inflating a balloon placed in the epidural space. In brain–dead pigs given saline, liver glycogen decreased from 45 ± 11 mmol/g DNA (mean ± SEM) to 7 ± 3 mmol/ g DNA after 6 hours. Thereafter, it increased to 28 ± 9 mmol/g DNA after 9 hours ( P = .05 compared with the 6–hour measurement). These changes were accompanied by transient increases in plasma adrenaline, glucose, free fatty acids (FFA), and glucagon. Following glucose/ insulin infusion, hepatic glycogen increased steadily and was approximately double after 12 hours ( P &lt; .01) in both brain–dead and in non–brain–dead pigs. In brain–dead pigs, the increases in the aforementioned blood measurements were smaller following glucose/insulin infusion than following saline infusion. However, studies of longer duration will be needed to examine these effects on a time scale that is relevant to human organ donors. In conclusion, the decrease in hepatic glycogen content after brain death could be prevented by intravenous glucose/insulin infusion probably because of a reduction of the adrenaline response to the induction of brain death.
Ronald F Welch
Authors: P Clark, D Shove
Journal: BMJ (2006)

​FormerFormer consultant pathologist Barnet General Hospital (b 1916; q Westminster Hospital 1939; MD, FRCPath), d 5 December 2005.



Figure 1



Ronald trained as a pathologist at the West London Hospital. He was then appointed pathologist to what later became Barnet General Hospital, where he pioneered and developed a comprehensive pathology service. From 1953 onwards he helped to develop the Barnet Ventilator, one of the first electronic ventilators to be used widely, both in anaesthetics and respiratory failure. In 1962 he established a radioisotope unit, the equipment largely being made in his department. Predeceased by his wife, Nancy, he leaves a partner, June Dalby-Welch; a daughter; and two grandsons.
Angiogenic Pathways in Diabetic Retinopathy
Authors: Lloyd Paul Aiello
Journal: New England Journal of Medicine (2005)

Visual loss is often considered the most feared complication of human disease, other than death. In 2002, 124 million people worldwide had poor vision and 37 million were blind.1 In developed countries, the primary causes of visual loss are age-related macular degeneration, in the elderly, and diabetic retinopathy, in working-age persons. It is estimated that diabetes mellitus affects 4 percent of the world's population, almost half of whom have some degree of diabetic retinopathy at any given time. Visual loss primarily occurs from either proliferation of new retinal vessels (proliferative diabetic retinopathy) or increased permeability of retinal vessels (diabetic macular . . .
Hypoxia causes permeability oedema in the constant-pressure perfused rat lung
Authors: M. Dehler, E. Zessin, P. Bärtsch, H. Mairbäurl
Journal: European Respiratory Journal (2006)

Alveolar hypoxia causes pulmonary oedema associated with increased lung capillary pressure and decreased alveolar fluid reabsorption. However, the role of altered permeability is unclear. The aim of the present study was to test whether hypoxia affects alveolar permeability and induces pulmonary oedema in rat lungs, and whether terbutaline affects oedema formation. Isolated lungs of normoxic rats were perfused at a constant pressure (12 cmH 2 O) and exposed to different levels of oxygenation (1.5–35% O 2 ). Terbutaline (10 −5 M) was applied as an aerosol or with the perfusate. Online measurements indicate an earlier onset of weight gain with an increasing degree of hypoxia and a shortened lung survival time (35% O 2 : ∼220 min; 1.5% O 2 : ∼120 min). Terbutaline did not prevent oedema formation in hypoxic lungs. The terbutaline-induced formation of cyclic adenosine monophosphate was decreased by 50% in hypoxia (1.5% O 2 ). In experiments terminated after 75 min, bronchoalveolar lavage fluid of hypoxic lungs contained protein that originated from perfusate indicating alveolar leakage. Since lactate dehydrogenase in perfusate was not increased at the onset of oedema formation, cell damage does not explain the increased permeability. In conclusion, these results indicate the formation of a leak for macromolecules of the isolated perfused rat lung, which is accelerated by hypoxia and causes alveolar flooding even at low perfusion pressure at a rate that exceeds absorption even after stimulation with terbutaline.
Metastatic Thyroid Carcinoma
Authors: Henry N. Wellman
Journal: JAMA (1974)

<h3>To the Editor.—</h3> Just a short comment on the BRIEF REPORT entitled "Metastatic Thyroid Carcinoma" by Walter B. Shelley, MD, et al (226:173, 1973). As a practitioner of nuclear medicine, with a degree of experience in following such patients as are reported by Dr. Shelley, it is extremely discouraging to continue to see these patients worked up and followed so poorly. It is amazing that Dr. Shelley only suggests, in passing, that "possibly the<sup>131</sup>I photoscan would have showed these metastases." It has been our common experience in these cases that an adequate work-up is not performed to establish whether the thyroid metastases are, or are not, functional. Since a high proportion of thyroid metastases as reported by both Beierwaltes and Pochin are functional, they are thus amenable to the use of radioactive iodine ablation. For some reason, this latter fact is not well recognized. Thus, as in the
Symptom evaluation in reflux disease: workshop background, processes, terminology, recommendations, and discussion outputs
Authors: J Dent
Journal: Gut (2004)

There has been no published indepth systematic evaluation of the best approaches to symptom evaluation in gastro-oesophageal reflux disease (GORD). A two day international multidisciplinary workshop was therefore held in Marrakech, Morocco, in September 2002 to address these issues. The aim of the workshop was to critically review the data regarding the reliability, processes, and priorities for symptom evaluation in GORD patients. The workshop was designed to give outputs that could be readily reported and to arrive at specific recommendations on best practice in symptom evaluation in reflux disease.
Seeing Is Believing
Authors: M. J. Friedrich
Journal: JAMA (2010)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
E3 ubiquitin ligase Cblb regulates the acute inflammatory response underlying lung injury
Authors: Kurt Bachmaier, Sophie Toya, Xiaopei Gao, Thomas Triantafillou, Sean Garrean, Gye Young Park, Randall S Frey, Stephen Vogel, Richard Minshall, John W Christman, Chinnaswamy Tiruppathi, Asrar B Malik
Journal: Nature Medicine (2007)
Splanchnic Hemodynamics and Oxygen Utilization During Hemorrhagic Shock in the Dog
Authors: EWALD E. SELKURT, GERHARD A. BRECHER, JOHN A. JENNINGS, STEPHEN A. PYE
Journal: Circulation Research (1956)

Portal vein and hepatic artery flow were measured with bristle flowmeters. Based on such measurements, oxygen utilization by both the intestine and liver was found to be significantly reduced after prolonged hypotension. Splanchnic vascular resistance did not increase significantly during hypotension, and following transfusion there was a phase of marked reduction particularly in the mesenteric component. This was followed by some degree of compensation which persisted until the terminal stages when splanchnic vascular resistance again declined. Terminally, mesenteric resistance again appeared to be the component of total splanchnic resistance which manifested failure of compensation. It is suggested that impaired oxygen utilization by the intestine and liver may be a key mechanism accountable for the inadequate splanchnic vascular compensation during hypotension and its ultimate failure.
Electrophysiologic abnormalities of the sinus node and atrium in patients with bundle branch block.
Authors: D G Wyse, J H McAnulty, S H Rahimtoola, E S Murphy
Journal: Circulation (1979)

Detailed electrophysiologic evaluation of the sinus node and atrium was undertaken in 26 patients.Half had bior trifascicular conduction disease (BTD) and the others had a narrow QRS (non-BTD).BTD and non-BTD groups were comparable with respect to age, sex and incidence of coronary artery disease (CAD).One or more electrophysiologic abnormalities of the sinus node or atrium were found in nine of 13 BTD patients (more than one abnormality was present in five) and a single isolated abnormality was seen in one of 13 non-BTD patients (p < 0.01).PA interval (41 ± 3 vs 28 ± 3 msec), sinus node recovery time (1289 ± 76 vs 988 ± 44 msec), corrected sinus node recovery time (369 ± 62 vs 221 ± 35 msec), atrial effec- tive (253 ± 14 vs 205 ± 11 msec) and functional (324 ± 15 vs 272 ± 9 msec) refractory periods were significantly longer in BTD than in non-BTD patients (p < 0.05).These differences were greatest when CAD patients were excluded and primary BTD patients (BTD without other evident cardiovascular disease) were compared with controls (narrow QRS without CAD).Sinoatrial conduction time was significantly longer in primary BTD patients (126 ± 11 msec) than it was in controls (82 8 msec).We conclude that electrophysiologic abnormalities of the sinus node and atrium are extremely common in patients with BTD, particularly primary BTD, and may cause symptomatic dysrhythmias.SEVERAL STUDIES HAVE SHOWN increased morbidity and mortality in patients with bi-and trifascicular conduction disease (BTD).'-"The current uncertainty and controversy about this type of conduction disease center on the role of atrioventricular (AV) block as the cause of symptoms and death.The value of a prolonged HV interval (i.e., trifascicular conduction disease) as a harbinger of advanced AV block and the need for "prophylactic" pacemakers in the latter patients have been particularly controver- sial.3'I Less attention has been given to sinus node and atrial dysfunction as a cause of morbidity and mor- tality in patients with BTD.Patients with sinoatrial conduction disorders (sick sinus syndrome) have a high incidence of distal conduction disease,8' but the converse relationship has not, to our knowledge, been shown.Therefore, we undertook electrophysiologic assessment of sinus node and atrial function in patients with bundle branch block. Materials and MethodsThe subjects were selected from patients undergoing diagnostic or investigational electrophysiologic study, coronary and left ventricular angiography, or hemodynamic cardiac catheterization and who met the study criteria.Informed consent was obtained.
Fibrinolytic Factors and the Risk of Myocardial Infarction or Sudden Death in Patients With Angina Pectoris
Authors: Ire`ne Juhan-Vague, Stephen D.M. Pyke, Marie Christine Alessi, Jorgen Jespersen, Frits Haverkate, Simon G. Thompson
Journal: Circulation (1996)

Background Disturbances of the fibrinolytic system that lead to decreased removal of fibrin deposits may be important risk factors for coronary thrombosis. There is as yet no consensus on the prognostic value of fibrinolytic parameters, which may be attributed in part to the choice of confounding variables controlled for. Methods and Results The ECAT study is a prospective multicenter study of 3043 patients with angina pectoris followed for 2 years. Baseline measurements included 10 fibrinolytic variables. The results were analyzed in relation to the subsequent incidence of myocardial infarction or sudden coronary death. They are presented before and after adjustment for clusters of confounding variables that are markers of different mechanisms: insulin resistance (body mass index, triglyceride, and HDL cholesterol), inflammation (fibrinogen and C-reactive protein), and endothelial cell damage (von Willebrand factor). An increased incidence of events was associated with higher baseline concentrations of tissue plasminogen activator (TPA) antigen ( P =.0002), plasminogen activator inhibitor-1 (PAI-1) activity ( P =.02), and PAI-1 antigen ( P =.001). The associations of PAI-1 activity and PAI-1 antigen with risk of events disappeared after adjustment for parameters reflecting insulin resistance but were not affected by other adjustments. TPA antigen was affected to a similar extent by adjustment for parameters reflecting insulin resistance, inflammation, or endothelial cell damage, but the risk association disappeared only after combined adjustments. Conclusions The prognostic role of PAI-1 in predicting coronary events is related principally to insulin resistance, whereas that of TPA antigen could be explained only by its relationship with different mechanisms, including insulin resistance, inflammation, and endothelial cell damage.
Effects of long-term treatment with amiodarone on exercise hemodynamics and left ventricular relaxation in patients with hypertrophic cardiomyopathy.
Authors: W J Paulus, P Nellens, G R Heyndrickx, E Andries
Journal: Circulation (1986)

The influence of long-term treatment with amiodarone on exercise hemodynamics and on left ventricular relaxation was studied prospectively in patients with hypertrophic cardiomyopathy. Rest-exercise hemodynamics (n = 9) and echocardiographic relaxation indexes (isovolumic relaxation time, dPW/dt) (n = 11) were measured in control conditions and after 5 weeks of oral amiodarone treatment (600 mg daily first week, 400 mg daily second week, 200 mg daily afterwards). Long-term amiodarone treatment in patients at rest caused a significant drop in heart rate from 80 +/- 11 to 75 +/- 11 beats/min (p less than .05), a rise in mean pulmonary artery pressure from 19 +/- 7 to 25 +/- 10 mm Hg (p less than .02), and a rise in mean pulmonary capillary wedge pressure from 11 +/- 4 to 17 +/- 8 mm Hg (p less than .05). Systemic arterial pressure, cardiac output, and systemic vascular resistance remained unaltered. Exercise tolerance assessed by serial supine bicycle stress testing was reduced in six of nine patients. Amiodarone treatment caused a significant rise in pulmonary capillary wedge pressure from 22 +/- 8 to 37 +/- 9 mm Hg (p less than .001) at the highest identical workloads and from 26 +/- 10 to 37 +/- 9 (p less than .005) at maximal symptom-limited workloads. Similarly, mean pulmonary artery pressure rose from 37 +/- 15 to 51 +/- 18 mm Hg (p less than .01) at highest identical workloads and from 42 +/- 19 to 51 +/- 18 mm Hg (p less than .01) at maximal symptom-limited workloads. There were no significant differences at maximal exercise level in heart rate, systemic arterial pressure, cardiac output, or exercise factor. Echocardiographic studies performed before and during long-term amiodarone treatment revealed no change in isovolumic relaxation time, end-diastolic or end-systolic posterior wall thickness, and peak posterior wall thinning rate. A negative inotropic action of amiodarone could explain the worsened rest and exercise hemodynamics observed during long-term treatment of patients with hypertrophic cardiomyopathy. Echocardiographic relaxation indexes remained unaltered despite the elevated left ventricular filling pressures. This finding could suggest a deleterious effect of amiodarone on myocardial inactivation, possibly similar in mechanism to the depressed myocardial inactivation observed in hypothyroidism.
Transport of Sick Newborn Babies
Authors: C. N. Storrs, M. R. H. Taylor
Journal: BMJ (1970)

When sick newborn babies are transferred to Hammersmith Hospital they are collected from the referring hospital or from home by a paediatric resident doctor and a nurse. They prepare the baby for the journey by giving any urgent treatment required, for procedures are difficult to carry out in a moving ambulance. Babies who are likely to become apnoeic are intubated before transport so that ventilation can be started immediately if required. The baby travels in a portable incubator, and special attention is paid to prevention of hypothermia, adequate oxygenation, and respiration. Altogether 122 babies were transferred in 1969, the main reasons being prematurity, hyaline membrane disease, and apnoeic attacks. Five improved during the journey, 102 did not change significantly and 15 became worse. There was no evidence that travel per se harmed any of the babies, though in a few cases deterioration might have been prevented had observation and treatment been easier in the ambulance. Fifty-eight (47%) of the babies eventually died, but the group was a highly selected one with a high proportion of small, immature, and ill babies. We conclude that for very ill newborn babies the advantages of transfer to an intensive care unit probably outweigh the disadvantages of transport, provided that the precautions described here are taken.
Quality of Diabetes Care for Immigrants in the U.S.
Authors: Florence J. Dallo, Fernando A. Wilson, Jim P. Stimpson
Journal: Diabetes Care (2009)

OBJECTIVE To compare achievement of the American Diabetes Association diabetes care recommendations for U.S.- and foreign-born individuals with diabetes. RESEARCH DESIGN AND METHODS Using the 2001-2006 Medical Expenditure Panel Surveys, we report estimates for receipt of a cholesterol test, routine checkup, influenza vaccination, eye examination, dental checkup, foot examination, and two or more A1C tests in 1 year for foreign- (n = 1,272) and U.S.-born (n = 5,811) individuals aged > or =18 years. We define a dichotomous variable representing full compliance with the above examinations. We provide descriptive characteristics of the sample and use multivariable analysis for each procedure with random effects logit regression. RESULTS Compared with U.S.-born individuals with diabetes, foreign-born individuals are younger, have lower education levels and income, are more likely to have public or no insurance, and are less likely to have a usual source of care. With adjustment for all potential confounders, foreign-born individuals are less likely to report having had an influenza vaccination (odds ratio 0.51 [95% CI 0.31-0.71]) or to be compliant with any one of the seven recommendations (0.64 [0.34-0.95]). CONCLUSIONS These findings demonstrate that immigrants are less likely than U.S.-born individuals with diabetes to adhere to any one of seven diabetes care recommendations in general and, specifically, are less likely to report having received an influenza vaccination. Because immigrants are less likely to use health care, clinicians should take advantage of the office visit to effectively communicate to the patient the importance of receiving an influenza vaccination.
Reduced amyloid-A-degrading activity in serum in amyloidosis associated with rheumatoid arthritis.
Authors: O Wegelius, A M Teppo, C P Maury
Journal: BMJ (1982)

<h3>Abstract</h3> <h3>Background</h3> This review aims to conduct a systematic review and meta-analysis to assess the prognostic value of shock index for prediction of severe Postpartum hemorrhage (PPH) in high-income countries. <h3>Method</h3> We will perform a systematic review and meta-analysis for diagnostic test accuracy (DTA). We will search CENTRAL, MEDLINE (Ovid), Web of Science, and other sources and include all relevant reports on the prognostic accuracy of shock index for severe PPH. The target condition is defined as severe PPH required higher-level care. Two review authors will independently screen the study eligibility and extract data from included studies. Two authors will also assess study quality using the QUADAS-2 (Quality Assessment of Diagnostic Accuracy Studies 2) tool. We will use the hierarchical models comprising both the bivariate model and the hierarchical summary receiver operating characteristic (HSROC) model for data synthesis if appropriate. We presented uncertainty of the accuracy estimates using 95% confidence intervals (CIs). <h3>Trial registration</h3> This review is submitted with University hospital medical information network clinical trial registry (UMIN-CTR) [UMIN 000044230]. <h3>Conflicts of interest</h3> All authors declare to have no conflicts of interest <h3>Funding</h3> None