tbuckley/cabot-search huggingface dataset:
An evaluation of the role of bone marrow biopsy in patients with multiple myeloma who achieve an unconfirmed stringent complete remission.
Authors: T. M. Mark, A. Koirala, R. N. Pearse, F. Zafar, D. Jayabalan, J. P. Leonard, M. Coleman, R. Niesvizky
Journal: Journal of Clinical Oncology (2010)

8144 Background: The latest guidelines for response published by the International Myeloma Working Group introduce sCR (stringent Complete Response) as a response criterion for patients who have normal free light chain ratio and absence of clonal cells in the bone marrow, in addition to satisfying all the criteria for complete response (CR). The clinical significance of sCR vs. those patients who are in sCR unconfirmed by bone marrow biopsy (uSCR) in terms of progression free survival (PFS) and overall survival (OS) is unknown. Methods: A retrospective cohort study of patients undergoing treatment for symptomatic multiple myeloma was performed using a institutional database for category of response and clinical outcomes. All subjects had serial disease evaluation with serum and urine protein electrophoresis, serum free light chain assay by nephelometry, and radiologic imaging when appropriate. The results of patients who achieved sCR and usCR (patients believed to have sCR but not confirmed by immunohistochemistry or immunofluorescence for absence of clonal cells on bone marrow biopsy) are reported. Results: A total of 56 patients had achieved either sCR (n = 38) or usCR (n = 18). The median time of follow-up was 3 years (range .04 – 6.67 years). The median PFS for sCR of 210 weeks was not significantly different than for usCR 142 weeks, (P = 0.12 by log-rank). The median overall survival was not reached for both groups, with a statistically equivalent OS at 4.5 years of 100% for patients achieving usCR versus 89% for sCR (P = 0.134 by log- rank). Conclusions: Persons with myeloma who achieve either a sCR or usCR have similar rates of progression and survival at 3 years of follow-up. Although more follow-up time may bear out a statistically valid difference in the clinical endpoints of PFS and OS, a normal free light chain assay for a patient may serve as less invasive alternative to bone marrow biopsy in conventional myeloma disease response assessment. No significant financial relationships to disclose.
Abstract 2751: An Implantable Carotid Sinus Baroreflex Activating System for Drug-Resistant Hypertension: Interim Chronic Efficacy Results from the Multi-Center Rheos Feasibility Trial
Authors: John Bisognano, James Sloand, Vasilios Papademetriou, Marcos Rothstein, Domenic Sica, John Flack, Terence L Pertile, Robert Kieval, Robert J Cody
Journal: Circulation (2006)
Abstract 17718: Right Ventricular Assist Device Removal in Patients with Apparently Unloading-Promoted Improvement of Right Ventricular Function: Criteria for Weaning Decisions
Authors: Michael Dandel, Evgenij Potapov, Thomas Krabatsch, Alexander Stepanenko, Henryk Siniawski, Christoph Knosalla, Hans B Lehmkuhl, Roland Hetzer
Journal: Circulation (2011)

Background: The complex right ventricular (RV) geometry and load dependency of indices used to quantify its function make RV assessments very challenging. Differences between right and left ventricular (LV) geometry, wall thickness, myofiber architecture, blood supply and load dependency of myocardial function, limit the use of data obtained from LV studies for RV assessment. The reliability of criteria used for weaning decisions in patients with a RV assist device (RVAD) is barely known. We assessed this issue. Methods: In 36 patients who were weaned from mechanical RV support since 2003 we analyzed echocardiographic data on RV size, geometry and function plus the data on pulmonary hemodynamics recorded during “off-pump” trials. The final goal was to identify the parameters with the highest predictive value for post-weaning stability of RV function. Wall motion velocity was measured by pulsed-wave tissue Doppler. Results: Of 36 evaluated patients, 19 were weaned from “short term” bridge to recovery designed RVADs and 17 from bridge to transplant designed biventricular assist devices (BVADs). Post-weaning right heart failure (RHF) recurrence occurred in 6 (16.7%) patients. Of these 6 recurrences, 4 occurred after BVAD removal and 2 after the removal of short term designed RVADs. To date 25 patients have already reached between 1 and 7 years of post-weaning RV stability. During final off-pump trials performed before RVAD removal all 36 patients had RV ejection fraction (RVEF) &gt; 45%, stable central venous pressure at values ≤ 12 mm Hg and ≤ grade 2 tricuspid regurgitation (TR). The mean pulmonary arterial pressure was between 18 and 30 mmHg. Off pump RV long/short axis ratio (L/S) &lt; 0.55 and the tricuspid annulus peak systolic velocity (TAPSm) &gt; 8 cm/s showed the highest predictive value for &gt; 1 year stable RV function after weaning (89.5% and 94.4%, respectively). In patients without elevated pulmonary vascular resistance both TAPSm ≤ 8 cm/s and L/S ≥ 0.55 appeared to be risk factors for early recurrence of RHF. Conclusion: RV geometry and the velocity of RV systolic wall motion during off pump trials in patients with RVEF ≥ 45% and without relevant TR are highly predictive for a stable RV function after RVAD removal.
Abstract 13462: Gata-5 is Required in Endocardial Cells for Proper Formation of the Aortic Valve
Authors: Brigitte Laforest, Gregor Andelfinger, Mona Nemer
Journal: Circulation (2010)

A key step in aortic valve development is the formation of the endocardial cushions (ECs) in the outflow tract (OFT). Subtle changes during this process can lead to congenital heart defects (CHDs) ...
Abstract 3238: Successful Direct Endoscopic Guided Double Valve Repair on the Beating Heart: Acute Calves Study
Authors: Akira Shiose, Hideyuki Fumoto, Tohru Takaseya, Hyun-Il Kim, Yoko Arakawa, Santosh Rao, Raymond Dessoffy, Tomislav Mihaljevic, Kiyotaka Fukamachi
Journal: Circulation (2009)

Objectives: The purpose of this study was to develop a new method for mitral and tricuspid valve surgery under direct endoscopic visualization on the beating heart. Method: Through a median sternot...
Quality improvement report: A laboratory based intervention to improve appropriateness of lipid tests and audit cholesterol lowering in primary care
Authors: W S. A Smellie, R. Lowrie, E. Wilkinson
Journal: BMJ (2001)

<h3>Abstract</h3> <b>Problem:</b> A need exists to reduce inequalities in lipid testing, to provide relevant, individual, patient based interpretation for users, and to audit lipid lowering in primary care. <b>Design:</b> Model to compare laboratory activity between different general practices; construction of computer based strategies to define the lipid tests to be done and to interpret results for primary and secondary coronary prevention patients; introduction of the strategies into routine use; monitoring of any change after the intervention; and investigation of the potential of the strategies to produce audit data for primary care groups. <b>Background and setting:</b> Hospital clinical laboratory serving 22 general practices covering 150 000 patients in Bishop Auckland area County Durham. <b>Key measurements for improvement:</b> Reduction in differences in testing for the different serum lipids in coronary prevention. Production of usable audit data for the primary care groups involved. <b>Strategies for change:</b> Four different categories of coronary prevention patient, with, for each category, the defined lipid tests to be done and advice to be given (based on the results), using the computer based strategies. <b>Effects of change:</b> Standardised test activity and the qualitative profile of the tests performed changed significantly. The strategies were readily adopted (median use 78%) within six months of introduction. <b>Lessons learnt:</b> Computer based strategies can correct qualitative and quantitative differences in test requesting, provide interpretative guidance in accordance with national guidelines, and offer a cost effective model to monitor results of cholesterol lowering in general practice.
Test-retest reliability and validity of the Structured Interview for Sleep Disorders According to DSM-III-R
Authors: E Schramm, F Hohagen, U Grasshoff, D Riemann, G Hajak, H G Weess, M Berger
Journal: American Journal of Psychiatry (1993)

The purpose of this study was to evaluate the reliability of sleep disorder diagnoses in DSM-III-R by using a newly developed interview, the Structured Interview for Sleep Disorders According to DSM-III-R (SIS-D) and to evaluate the concordance between these diagnoses and sleep laboratory data. In addition, the sources of disagreements between two interviewers in the diagnoses given to the same patient were determined.Two different interviewers used the SIS-D to diagnose 68 patients with complaints of sleep disorders. The concordance between these interviewers' diagnoses and polysomnographic findings was investigated by using kappa statistics.There were excellent reliabilities for almost all current main diagnostic categories and good concordance between diagnoses made on the basis of the structured interview and polysomnographic data. The main source of disagreement between interviewers was found in the symptom information given by the patient.These findings provide support for the utility of DSM-III-R sleep disorder diagnoses and for their retention in DSM-IV. These findings also accord well with a recent literature review of the DSM-III-R diagnosis of primary insomnia by the DSM-IV Work Group on Sleep Disorders. The good concordance between interview diagnoses and polysomnographic data suggests that a structured interview such as the SIS-D may be a useful screening instrument. The authors discuss the implications of these findings for the polysomnographic evaluation of chronic insomnia.
研究方法与报告 BMJ开辟新栏目：怎样做研究设计和撰写论文
Authors: Trish, Groves, 安伟, 武阳丰
Journal: BMJ (2009)

大约15年前，医学统计学教授及BMJ资深统计学顾问Doug Altman就曾在BMJ上发文问到：“当看到有人使用错误的研究方法（无论是故意或是无意），或是以错误的方式使用正确的研究方法，或者错误的解释他们的结果，或者只是选择性的报告了结果，或者只是选择性的引用文献，或者下了并未得到确证的结论，我们会做何反应？我们一定会感到震惊。但是不论是在综合性或是专科性的杂志里，许多医学文献的研究都普遍存在以上现象。
Interim results of an observational study evaluating the impact of ethnic origin on the effect of second-line treatment with pemetrexed (P) for advanced non-small cell lung cancer (NSCLC).
Authors: E. J. Pennella, G. Peltz, A. C. Girvan, G. Pohl, D. E. Faries, M. D. Marciniak, C. K. Obasaju, E. J. Stepanski, L. Schwartzberg, A. A. Adjei
Journal: Journal of Clinical Oncology (2010)

e18055 Background: There is limited information on the impact of race and ethnicity on clinical outcomes and resource utilization during lung cancer treatment. This prospective, observational study is evaluating the impact of ethnicity on disease control rate (DCR) in patients (pts) with NSCLC treated with P in the second-line setting. Methods: Eligibility criteria include stage IIIB or IV NSCLC pts receiving single-agent P for second-line therapy in routine clinical practice. This report describes observations from an early examination of the data of pts from 4 different ethnic origins: Caucasian (C), African (AA), Asian (A), and Hispanic (H). DCR was defined as the rate of complete response (CR) + partial response (PR) + stable disease (SD). Noninferiority of minority patients to C will be concluded if the confidence interval (CI) upper limit of the estimated mean DCR difference is less than 0.14. Results: See Table. Conclusions: Race/ethnicity was associated with differences in baseline characteristics (age, gender, education level, marital status, income, private insurance, and smoking status) that may influence clinical outcomes and resource utilization in the second-line treatment of advanced NSCLC with P. Although the estimates for DCR are similar for each of the ethnic groups, the CIs are not yet sufficiently narrow to formally declare non-inferiority at the prespecified level. Additional data are needed to establish a definitive conclusion. C (N = 305) AA (N = 57) A (N = 27) H (N = 14) P value (C vs. AA) Mean age, yrs 66 63 65 61 0.02 Male, % 53 68 44 57 0.03 Adenocarcinoma, % 63 67 85 79 0.53 Prior surgery, % 30 18 22 50 0.06 Current smoker, % 26 39 0 21 0.06 ECOG PS of 0 or 1, % 78 88 90 83 0.14 Income ≤$25,000, % 28 51 22 36 0.0001 Private health insurance, % 49 29 33 33 0.03 Married, % 62 40 63 43 0.01 Some college, % 40 26 41 36 <0.05 DCR, % 40 41 71 22 − Mean DCR difference, % (CI upper limit of DCR) Ref (NA) −0.03 (0.30) −0.34 (0.19) 0.11 (0.44) − PFS, mos (95% CI) 2.6 (2.3, 3.0) 3.1 (1.9, 3.8) 3.9 (1.8, NE) 2.3 (1.9, 3.7) 0.8 OS, mos (95% CI) 5.9 (5.1, 6.8) 7.8 (3.6, 12.5) NE (1.8, NE) NE (NE, NE) 0.7 Author Disclosure Employment or Leadership Position Consultant or Advisory Role Stock Ownership Honoraria Research Funding Expert Testimony Other Remuneration Lilly Lilly Lilly
Effects of Oxyphenbutazone (Tandearil) on Plasma Seromucoids: II. In Postoperative Inflammation
Authors: R BARCELO, C LEBLANC, P RIOPEL, L P LEGRESLEY
Journal: JAMA (1963)

The efficacy of oxyphenbutazone (OPB) in the control of postoperative inflammation was investigated, and previous findings were extended on the rate at which the inflammatory response of plasma seromucoids was significantly modified by this drug. Eighty - five surgical patients (hemorrhoidectomy, 39; vaginal hysterectomy, 23; tonsillectomy, 14; submucosal resection of nasal cavity, 9) were studied by the double-blind method. OPB was administered orally in a daily dosage of 400 mg. with a priming dose on the evening before surgery. Effective control of postsurgical inflammation was achieved in 34 of 46 treated subjects as compared with similar results in eight of 39 controls. Control of postoperative pain was pronounced when OPB was used. One patient developed an urticarial rash. Chemical studies were carried out in 65 surgical patients (39 treated with OPB; 26 controls). In the postoperative phase, mean plasma seromucoid values increased from presurgical levels by 39% in controls and by 13.9% in OPB-treated subjects. Hence, results of this clinical trial clearly demonstrate the usefulness of OPB in the control of postsurgical inflammation. Moreover, results of the chemical studies are in accordance with those previously obtained in animals.
AIDS: A Global Perspective
Authors: Jonathan M. Mann, James Chin
Journal: New England Journal of Medicine (1988)

The origins of human immunodeficiency virus type 1 (HIV-1) remain uncertain, but the available evidence indicates that the current HIV-1 pandemic started, silent and unnoticed, during the mid to late 1970s.1 The recognition of AIDS in 1981, discovery of HIV-1 in 1983, and wide availability of diagnostic assays for antibodies to HIV-1 since 1985 have led gradually to a clearer picture of the worldwide extent and distribution of HIV-1 infection.2 An international surveillance of HIV infection and the acquired immunodeficiency syndrome (AIDS) is maintained by the Global Programme on AIDS of the World Health Organization (WHO). As of July 1, . . .
Christmas Disease
Authors: R. Biggs, A. S. Douglas, R. G. Macfarlane, J. V. Dacie, W. R. Pitney, C. Merskey, J. R. O'Brien
Journal: BMJ (1952)

PARALYSIS OF EXTERNAL POPLITEAL NERVE I the patients are not clear, we would emphasize that in these the clinical picture and duration of the disability fall well within the limits of those whose aetiology is more certain. TreatmentWith regard to treatment, we would make the following observations.Patients should be warned against crossing legs when sitting.There is no justification for the admission of these patients to hospital.A toe-raising spring over- comes the essential disability and even in heavy industry there is no need for the patient to remain off work.Massage, coloured lights, and other forms of passive physiotherapy, not to mention the administration of vitamin B1, play no part whatever in treatment.The patient should be instructed to carry out active movements of the affected muscles as often as possible when not wearing a spring, and, indeed, the spring itself is necessary only in the event of a severe paralysis of the tibialis anticus. Summary and ConclusionsParalysis of the external popliteal nerve, excluding the results of gross trauma, is not uncommon.Such paralysis generally (if not always) results from local nerve ischaemia, and simple mechanical factors can usually be found; these include kneeling, bandaging, crossing the legs while sitting, lying on a hard surface, and the wearing of knee-pads.Previous loss of weight conduces to this type of damage.Motor paralysis is often complete, but sensory loss is frequently absent and is never profound.The condition is always painless, and the onset sudden.Complete recovery is common and partial recovery the rule.
DNA Fiber Fluorescence In Situ Hybridization Analysis of Immunoglobulin Class Switching in B-Cell Neoplasia: Aberrant CH Gene Rearrangements in Follicle Center-Cell Lymphoma
Authors: Jan-Willem Vaandrager, Ed Schuuring, Hanneke C. Kluin-Nelemans, Martin J.S. Dyer, Anton K. Raap, Philip M. Kluin
Journal: Blood (1998)
Proximal Aortic Distensibility Is an Independent Predictor of All-Cause Mortality and Incident CV Events
Authors: Alban Redheuil, Colin O. Wu, Nadjia Kachenoura, Yoshiaki Ohyama, Raymond T. Yan, Alain G. Bertoni, Gregory W. Hundley, Daniel A. Duprez, David R. Jacobs, Lori B. Daniels, Christine Darwin, Christopher Sibley, David A. Bluemke, João A.C. Lima
Journal: Journal of the American College of Cardiology (2014)
Abstract 2697: Role of Physiological Late Sodium Current in the Reverse-use Dependency of Potassium Current Inhibitors
Authors: Lin Wu, Hong Li, John C Shryock, Luiz Belardinelli
Journal: Circulation (2009)

Background: Reverse-use dependency (RUD) of an action potential prolongation by IKr inhibitors is proarrhythmic. We hypothesized that endogenous (physiological) late Na+ current (late INa) may cont...
Discriminating features of borderline patients
Authors: John G. Gunderson, Jonathan E. Kolb
Journal: American Journal of Psychiatry (1978)

Borderline patients were compared with schizophrenic patients, neurotic depressed patients, and a group of patients with differing diagnoses. The purpose of this comparison was to find out whether borderline patients could be discriminated from other psychopathological groups and whether a discrete list of recognizable characteristics discriminating borderline patients could be isolated. According to the results of the comparison, borderline patients can be discriminated with high accuracy from matched comparison groups with whom diagnostic confusion is common. Seven criteria provided a clinically sensible and practical means of approaching the diagnosis of borderline disorder.
Childhood eczema
Authors: Miriam Santer, Sue Lewis-Jones, Tom Fahey
Journal: BMJ (2005)

Recombinant mouse mast cell protease 6 (mMCP-6) was generated to study the role of this tryptase in inflammatory reactions. Seven to forty-eight hours after the i.p. injection of recombinant mMCP-6 into BALB/c, mast cell-deficient WCB6F<sub>1</sub>-<i>Sl/Sl</i><sup>d</sup>, C5-deficient, or mMCP-5-null mice, the number of neutrophils in the peritoneal cavity of each animal increased significantly by &gt;50-fold. The failure of the closely related recombinant tryptase mMCP-7 to induce a comparable peritonitis indicates that the substrate specificities of the two tryptases are very different. Unlike most forms of acute inflammation, the mMCP-6-mediated peritonitis was relatively long lasting and neutrophil specific. Mouse MCP-6 did not induce neutrophil chemotaxis directly in an in vitro assay, but did promote chemotaxis of the leukocyte in the presence of endothelial cells. Mouse MCP-6 did not induce cultured human endothelial cells to express TNF-α, RANTES, IL-1α, or IL-6. However, the tryptase induced endothelial cells to express large amounts of IL-8 continually over a 40-h period. Neither enzymatically active mMCP-7 nor enzymatically inactive pro-mMCP-6 was able to induce endothelial cells to increase their expression of IL-8. Although the mechanism by which mMCP-6 induces neutrophil accumulation in tissues remains to be determined, the finding that mMCP-6 induces cultured human endothelial cells to selectively release large amounts of IL-8 raises the possibility that this tryptase regulates the steady state levels of neutrophil-specific chemokines in vivo during mast cell-mediated inflammatory events.
Readings in Medical Artificial Intelligence: The First Decade.
Authors: William J. Clancey, Edward H. Shortliffe
Journal: Annals of Internal Medicine (1984)

or training. The chapter by Ralph Mann on sprinting and hurdling offers advice on how a knowledge of biomechanics can improve performance. It could be improved with the addition of a set of recommendations for the coach and athlete. The other chapters on biomechanics do not effectively tell athletes how they can use the information provided to improve their performance or prevent injury. The chapters on psychology
Abstract 3233: Plotting the Time Course of LVH Regression and Remodeling Imparted by Aortic Valve Replacement for Severe Aortic Stenosis; A Cardiovascular MRI Study Sponsored by the American Heart Association
Authors: Robert W Biederman, James A Magovern, Saundra B Grant, Ronald B Williams, June A Yamrozik, Diane A Vido, Vikas K Rathi, Mark Doyle
Journal: Circulation (2009)

In pts with severe aortic stenosis (AS), long-term data tracking surgically induced effects of afterload reduction via aortic valve replacement (AVR) on reverse LV remodeling are not available. Ech...
Abstract 14073: The Nucleophilic Dipeptide Carnosine Prevents Atherogenesis in ApoE-Null Mice
Authors: Oleg A Barski, Shahid P Baba, Zhengzhi Xie, Joseph D Hoetker, Abhinav Agarwal, Srinivas D Sithu, Aruni Bhatnagar, Sanjay Srivastava
Journal: Circulation (2011)

Atherogenesis is associated with the accumulation of oxidized lipids within atherosclerotic lesions. Among those, aldehydes generated from fragmentation of unsaturated fatty acids are the major, an...
Does viral interference affect spread of influenza?
Authors: A Linde, M Rotzén-Östlund, B Zweygberg-Wirgart, S Rubinova, M Brytting
Journal: Eurosurveillance (2009)

This short communication hypothesises that rhinovirus epidemics occurring after start of school may interfere with the spread of influenza during the period when warm and humid climate decreases the influenza spread by aerosol. Limited laboratory data supporting this hypothesis are included in the article, but the report is written mainly to stimulate interest and research concerning the possibility that viral interaction may affect influenza epidemiology.
Alzheimer's-disease-related protein in geriatric schizophrenic patients with cognitive impairment
Authors: P Powchik, M Davidson, C B Nemeroff, V Haroutunian, D Purohit, M Losonczy, G Bissette, D Perl, H Ghanbari, B Miller
Journal: American Journal of Psychiatry (1993)

The authors compared Alz-50 immunoreactivity in the brain tissue of nine cognitively impaired elderly schizophrenic patients and 13 elderly comparison subjects, both without neuritic plaques or neurofibrillary tangles, and 13 patients with Alzheimer's disease. Alz-50 reactivity was absent in the schizophrenic patients, indicating that geriatric, cognitively impaired patients are unlikely to display the pathology of Alzheimer's disease.
Off Balance
Authors: Vinod E. Nambudiri, Anand Vaidya, Thomas Cochrane, David Barbie
Journal: New England Journal of Medicine (2014)

A 64-year-old right-handed man presented with gait instability, visual changes, and diffuse weakness. Two months earlier, he had noticed a sensation of flashing lights in his visual field. During the two weeks preceding presentation, he noted intermittent double vision and visual difficulties while driving his car, missing multiple turns because he failed to notice them. During this . . .