Cosmetic Surgical Procedures and Connective Tissue Disease: The Cleopatra Syndrome Revisited
Authors: Marc C. Hochberg
Journal: Annals of Internal Medicine (1993)

Editorials15 June 1993Cosmetic Surgical Procedures and Connective Tissue Disease: The Cleopatra Syndrome RevisitedMarc C. Hochberg, MD, MPHMarc C. Hochberg, MD, MPHUniversity of Maryland at Baltimore, Baltimore, MD 21201-1734.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-118-12-199306150-00013 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail During the past 30 years, numerous authors have reported single patients as well as case series of patients with presumed and well-defined connective tissue diseases after cosmetic surgical procedures. These include reports of the development of systemic sclerosis and other connective tissue diseases after augmentation mammoplasty with injections of paraffin and silicone, as well as placement of silicone gel-filled breast prostheses, and a dermatomyositis or polymyositis-like syndrome after bovine collagen implants.The case series reported by Bridges and colleagues, in this issue of Annals, is another series of patients referred to rheumatologists interested in a potential silicone-rheumatic disease link, for ...References1. Miyoshi K, Miyaoka T, Kobayashi Y, Itakura T, Nishijo K, Higashibara M, et al. Hypergammaglobulinemia by prolonged adjuvanticity in man: disorders developed after augmentation mammoplasty. Ijishimpo. 1964; 2122:9-14. Google Scholar2. Kumagai Y, Shiokawa Y, Medsger TA Jr, Rodnan GP. Clinical spectrum of connective tissue disease after cosmetic surgery: observations on eighteen patients and a review of the Japanese literature. Arthritis Rheum. 1984; 27:1-12. 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Google Scholar23. Wigley FM, Miller R, Hochberg MC, Steen V. Augmentation mammoplasty in patients with systemic sclerosis: data from the Baltimore Scleroderma Research Center and Pittsburgh Scleroderma Data Bank (Abstract). Arthritis Rheum. 1992; 35:S46. Google Scholar24. Moss AJ, Hamburger S, Moore RM Jr, Jeng LL. Use of selected medical device implants in the United States, 1988. Advance data from vital and health statistics; no 191. Hyattsville, Maryland; National Center for Health Statistics; 1990. Google Scholar Author, Article, and Disclosure InformationAuthors: Marc C. Hochberg, MD, MPHAffiliations: University of Maryland at Baltimore, Baltimore, MD 21201-1734.Corresponding Author: Marc C. Hochberg, MD, MPH, Departments of Medicine and Epidemiology and Preventive Medicine, University of Maryland School of Medicine, 419 West Redwood Street, Suite 620, Baltimore, MD 21201. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoAssociation between Bovine Collagen Dermal Implants and a Dermatomyositis or a Polymyositis-like Syndrome Jean Cukier , Richard A. Beauchamp , Joseph S. Spindler , Sarah Spindler , Carlos Lorenzo , and David E. Trentham A Clinical and Immunologic Evaluation of Women with Silicone Breast Implants and Symptoms of Rheumatic Disease Alan J. Bridges , Carol Conley , Grace Wang , David E. Burns , and Frank B. Vasey Metrics Cited byOccupational Connective Tissue DisordersOccupational Connective Tissue DisordersOccupational Connective Tissue DisordersComplications and their managementComplications of Soft Tissue FillersComplications of Fillers: OverviewOccupational Connective Tissue DisordersA mathematical model for assessing the temporal association between health disorders and medical treatmentsSilicone Breast Implants, Breast Cancer and Specific Connective Tissue Diseases: A Systematic Review of the Data in the Epidemiological LiteratureInjectable Collagen and a Rare Adverse Event—True Association or Artifact?OCCUPATIONAL AND ENVIRONMENTAL INFLUENCES ON SCLERODERMALack of association between augmentation mammoplasty and systemic sclerosis (scleroderma)The Association of Augmentation Mammoplasty with Connective Tissue Disease, Including Systematic Sclerosis (Scleroderma): A Meta-AnalysisFrequency of augmentation mammoplasty in patients with systemic sclerosis: Data from the Johns Hopkins—University of Maryland Scleroderma CenterMicrolipoinjection and Autologous CollagenIs there an association between injectable collagen and polymyositis/dermatomyositis?Current status of silicone gel breast implantsAutologous Collagen? 15 June 1993Volume 118, Issue 12Page: 981-983KeywordsAntibodiesAutoimmune diseasesCase seriesConnective tissue diseasesDermatomyositisEpidemiologyFood and Drug AdministrationMyositisPolymyositisScleroderma ePublished: 15 August 2000 Issue Published: 15 June 1993 Copyright & PermissionsCopyright © 1993 by American College of Physicians. 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