THE IMPORTANCE OF THE FRACTIONAL SERUM BILIRUBIN DETERMINATION IN CLINICAL MEDICINE
Authors: C J WATSON
Journal: Annals of Internal Medicine (1956)

Article1 September 1956THE IMPORTANCE OF THE FRACTIONAL SERUM BILIRUBIN DETERMINATION IN CLINICAL MEDICINEC. J. WATSON, M.D., Ph.D., F.A.C.P.C. J. WATSON, M.D., Ph.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-45-3-351 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptIt was the great contribution of Hijmans van den Bergh and his associates, Snapper and Muller, to apply the Ehrlich-Proscher diazo reaction for bilirubin to the bilirubin of blood serum and body fluids in qualitative and quantitative fashion.1, 2This work, which appeared during and just at the end of World War I, gave a new impetus to the study of jaundice, liver disease and the anemias. In the subsequent years an extensive literature has accumulated on the subject, from both fundamental and clinical points of view. There is universal agreement on the specificity and general value of the total...Bibliography1. Hijmans van den BerghSnapper AAI: Die Farbstoffe des Blutserums, Deutsches Arch. f. klin. Med. 110: 540, 1913. Google Scholar2. Hijmans van den Bergh AA: Der Gallenfarbstoff im Blute, 1918, Barth, Leipzig. Google Scholar3. MalloyEvelyn HTKA: Determination of bilirubin with the photoelectric colorimeter, J. Biol. Chem. 119: 480, 1937. CrossrefGoogle Scholar4. DucciWatson HCJ: The quantitative determination of the serum bilirubin with special reference to the prompt-reacting and the chloroform soluble types, J. Lab. and Clin. Med. 30: 293, 1945. Google Scholar5. ZieveHillHansonFalconeWatson LEMABCJ: Normal and abnormal variations and clinical significance of the one-minute and total serum bilirubin determinations, J. Lab. and Clin. Med. 38: 446, 1951. MedlineGoogle Scholar6. FeiglQuerner JE: Bilirubinämie, Ztschr. f. d. ges. exper. Med. 9: 153, 1919. CrossrefGoogle Scholar7. 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WatsonHoffbauer CJFW: The problem of prolonged hepatitis with particular reference to the cholangiolitic type and to the development of cholangiolitic cirrhosis of the liver, Ann. Int. Med. 25: 195, 1946. LinkGoogle Scholar35. BillingLathe BHGH: The excretion of bilirubin as an ester glucuronide giving the direct van den Bergh reaction, Biochem. J., Proc. 63: 6, 1956 (March 22). Google Scholar36. Schmid R: Direct-reacting bilirubin, bilirubin glucuronide, in serum, bile and urine, Science 124: 76, 1956. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Minneapolis, Minnesota*Presented at the Thirty-seventh Annual Session of The American College of Physicians, Los Angeles, California, April 16, 1956.From the Department of Medicine, University of Minnesota Medical School and Hospital.Aided in part by a contract with the Office of the Surgeon General, U. S. Army.Requests for reprints should be addressed to C. J. Watson, M.D., 412 Union Street, Southeast, Minneapolis 14, Minnesota. 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RAMOS-MORALES, M.D., R. S. DÍAZ-RIVERA, M.D., F.A.C.P., A. A. CINTRÓN-RIVERA, M.D., JOSÉ A. RULLÁN, M.D., A. S. BENENSON, JOSEFINA ACOSTA-MATIENZO, M.S.Liver diseaseBile Pigments in JaundiceParenchymatous Liver Disease (1956-1957)Color Reaction of Bilirubin with Sulfuric Acid: a Direct Diazo-Reacting Bilirubin SulfateLiver Function Tests and Their InterpretationChronic idiopathic jaundiceBilirubin metabolism in jaundiceTHE IDENTIFICATION OF “DIRECT-REACTING” BILIRUBIN AS BILIRUBIN GLUCURONIDEEvaluation of hepatic dysfunctionCirrhosis of the liverThe Chromatographic Separation of the Serum Bile Pigments in Jaundice 1 September 1956Volume 45, Issue 3Page: 351-368KeywordsBileBilirubinCarcinomatosisCirrhosisHospital medicineLesionsLiver diseasesQualitative studiesSpecificitySurgeons ePublished: 1 December 2008 Issue Published: 1 September 1956 PDF downloadLoading ...