Triamterene-Induced Nephrolithiasis
Authors: Bruce Ettinger, Eli Weil, Neils. Mandel, Stephen Darling
Journal: Annals of Internal Medicine (1979)

Brief Reports1 November 1979Triamterene-Induced NephrolithiasisBRUCE ETTINGER, M.D., ELI WEIL, M.D., NEILS. MANDEL, Ph.D., STEPHEN DARLING, Ph.D.BRUCE ETTINGER, M.D.Search for more papers by this author, ELI WEIL, M.D.Search for more papers by this author, NEILS. MANDEL, Ph.D.Search for more papers by this author, STEPHEN DARLING, Ph.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-91-5-745 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptA patient passed kidney stones composed entirely of a mixture of triamterene and a metabolic product of triamterene. Although triamterene has been widely used for more than 15 years, there are no previous reports of triamterene-induced nephrolithiasis.A 52-year-old woman was referred for passing multiple small urinary stones. She had been treated with reserpine and hydrochlorothiazide for many years because of hypertension and coronary artery disease. Two and one half years before referral, triamterene therapy was added to correct hypokalemia. Eight months before referral the dosage was increased from 300 mg to 350 mg daily, taken in four divided doses....References1. PRUITTWINKELDAYTON AJP. Variations in the fate of triamterene. Clin Pharmacol Ther. 1977;21:610-19. CrossrefMedlineGoogle Scholar2. DAYTONANSLEYPRUITTWINKLERUDMAN PJAJD. Impairment of p-hydroxylation of triamterene (T) in patients with cirrhosis. Pharmacologist. 1976;18:153. Abstract. Google Scholar3. PRUITTDAYTONSTEINHORST APJ. Fate of triamterene in man. Clin Res. 1974;22:77A. Abstract. Google Scholar4. ANDRASCHFINKSCHMID HTE. Uber die Harnausscheidung des Antikaliuretikums Triamterene und seines phenolischen Metaboliten 2, 4, 7-Triamino-6-p-hydroxyphenylpteridin bei Lebergesunden und Kranken mit Leberzirrhose. Z Gastroenterol. 1971;9:240-5. MedlineGoogle Scholar5. BABATUDHOPEWILSON WGG. Triamterene, a new diuretic drug: I. Studies in normal men and in adrenalectomized rats. Br Med J. 1962;2:756-60. CrossrefMedlineGoogle Scholar6. BABATUDHOPEWILSON WGG. Triamterene, a new diuretic drug: II. Clinical trial in oedematous patients. Br Med J. 1962;2:760-4. CrossrefMedlineGoogle Scholar7. PRUITTMCNAYDAYTON AJP. Transfer characteristics of triamterene and its analogs: central nervous system, placenta, and kidney. Drug Metab Dispos. 1975;3:30-41. MedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: BRUCE ETTINGER, M.D.; ELI WEIL, M.D.; NEILS. MANDEL, Ph.D.; STEPHEN DARLING, Ph.D.Affiliations: PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byMechanistic approach to herbal formulations used for urolithiasis treatmentRaman Spectroscopy for the Diagnosis of Intratubular Triamterene CrystallizationDrug-Induced Kidney Stones and Crystalline Nephropathy: Pathophysiology, Prevention and TreatmentAccurate stone analysis: the impact on disease diagnosis and treatmentMiscellaneous Stone TypesDrug-Induced Renal StonesDiureticsSECONDARY AND MISCELLANEOUS UROLITHIASISThe analysis of peculiar urinary (and other) calculi: an endless source of challengeDiureticsMEDICAL THERAPYAnalysis of Urinary Calculi Containing Triamterene. 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SOCOLOW, M.D.NephrolithiasisPharmacologic Prophylaxis of Calcium StonesUrinary Stones of Unusual Etiology 1 November 1979Volume 91, Issue 5Page: 745-746KeywordsHypertensionKidney stonesReserpineStable coronary artery disease ePublished: 1 December 2008 Issue Published: 1 November 1979 PDF downloadLoading ...