tbuckley/cabot-search huggingface dataset:
Abstract 106: Effect of Prehospital Portable Monitoring of Cerebral Regional Oxygen Saturation in Patients with Out-of-Hospital Cardiac Arrest
Authors: Tomoya Hirose, Tadahiko Shiozaki, Junji Nomura, Kazuya Katsura, Naoki Ehara, Akinori Wakai, Mitsuo Ohnishi, Sumito Hayashida, Daikai Sadamitsu, Takeshi Shimazu
Journal: Circulation (2014)

Introduction:  In recent years, measurement of cerebral regional oxygen saturation (rSO 2 ) has attracted attention during resuscitation. However, serial changes of cerebral rSO 2  in pre-hospital settings are unclear. The objective of this study was to clarify serial changes in cerebral rSO 2  of patients with out-of-hospital cardiac arrest in the pre-hospital setting.   Hypothesis:  A pre-hospital portable cerebral rSO 2  monitoring system would be useful device in resuscitation.   Methods:  We developed a portable rSO 2  monitor (HAND ai TOS®), which is small enough to carry in pre-hospital settings. The sensor is attached to the patient’s forehead by the Emergency Life-saving Technician (ELT), and it monitors rSO 2  continuously. The normal range of rSO 2  was determined from 15 healthy patients.   Results:  The normal range of rSO 2  was 71.2±3.9%. From June 2013 through February 2014, serial changes of cerebral rSO 2  in 4 patients were evaluated. In three patients in cardiopulmonary arrest when the ELT started cerebral rSO 2  measurement (1 man, 2 women; mean age, 54.0±10.1 years), mean rSO 2  was 51.4±10.1% at the time measurement was started and was 51.5±5.5% just before hospital arrival. None of these patients had return of spontaneous circulation (ROSC) in the pre-hospital setting. In the one patient (86-year-old woman) with ROSC when ELT started cerebral rSO 2  measurement, cerebral rSO 2  was 67.3% at measurement start, it dropped gradually to 54.5%, and then rose to 74.3% (Figure). The cerebral oxygenation was impaired due to possible cardiac arrest again, and after that, ROSC led to the recovery of cerebral blood flow.   Conclusions:  By carrying out continuous measurement of cerebral rSO 2  in the pre-hospital setting, the changes of cerebral oxygenation were detected. Further evaluation of the validity of pre-hospital cerebral rSO 2  monitoring may lead to a new resuscitation strategy in the pre-hospital setting.
New stroke drug in trials
Authors: Abi Berger
Journal: BMJ (2001)

A new drug that limits brain damage after a stroke has entered large scale (phase III) clinical trials which, if successful, could lead to its being licensed. The drug, made by Bristol-Myers Squibb in the United States, has been designed to prevent the cell death that tends to follow an ischaemic episode ( Nature Medicine 2001;7:471-7).

Soon after an ischaemic stroke occurs, the core area of the brain immediately around the occluded blood vessel loses most of its oxygen supply and …
Sun behaviour after cutaneous malignant melanoma: a study based on ultraviolet radiation measurements and sun diary data
Authors: L.W. Idorn, P. Datta, J. Heydenreich, P.A. Philipsen, H.C. Wulf
Journal: British Journal of Dermatology (2012)

Journal Article Sun behaviour after cutaneous malignant melanoma: a study based on ultraviolet radiation measurements and sun diary data Get access L.W. Idorn, L.W. Idorn Dermatological Research Department D92, Bispebjerg Hospital, University of Copenhagen, Copenhagen DK‐2400, Denmark Luise Winkel Idorn. E‐mail: luise.idorn@gmail.com Search for other works by this author on: Oxford Academic Google Scholar P. Datta, P. Datta Dermatological Research Department D92, Bispebjerg Hospital, University of Copenhagen, Copenhagen DK‐2400, Denmark Search for other works by this author on: Oxford Academic Google Scholar J. Heydenreich, J. Heydenreich Dermatological Research Department D92, Bispebjerg Hospital, University of Copenhagen, Copenhagen DK‐2400, Denmark Search for other works by this author on: Oxford Academic Google Scholar P.A. Philipsen, P.A. Philipsen Dermatological Research Department D92, Bispebjerg Hospital, University of Copenhagen, Copenhagen DK‐2400, Denmark Search for other works by this author on: Oxford Academic Google Scholar H.C. Wulf H.C. Wulf Dermatological Research Department D92, Bispebjerg Hospital, University of Copenhagen, Copenhagen DK‐2400, Denmark Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 168, Issue 2, 1 February 2013, Pages 367–373, https://doi.org/10.1111/bjd.12066 Published: 01 February 2013 Article history Accepted: 16 September 2012 Published: 01 February 2013
Abstract 113: Ventilation is not Necessary During Cardiopulmonary Resuscitation in a Rat Model of Hemorrhagic Cardiac Arrest
Authors: Takumi Taniguchi, Hideo Inaba
Journal: Circulation (2007)

Recent studies showed that arterial blood pressure during hemorrhagic shock is made worse with hyperventilation and improved with hypoventilation. However, there are few studies about the ventilati...
The Cost Effectiveness of Implantable Cardioverter-Defibrillators
Authors: Jack Zwanziger, W. Jackson Hall, Andrew W. Dick, Hongwei Zhao, Alvin I. Mushlin, Rebecca Marron Hahn, Hongkun Wang, Mark L. Andrews, Cathleen Mooney, Hongyue Wang, Arthur J. Moss
Journal: Journal of the American College of Cardiology (2006)
Gene expression profiling of primary cutaneous melanoma: Expression of replication origins firing genes predicts clinical outcome
Authors: A. Spatz, V. Winnepenninckx, V. Lazar, S. Michiels, P. Dessen, M. Stas, A. M. Eggermont, A. Sarasin, T. Tursz, J. Van Den Oord
Journal: Journal of Clinical Oncology (2006)

8024 Background: Gene-expression profiling in human cutaneous melanomas is impaired by the difficulty in getting access to a retrospective collection of frozen tumors. Thus, compared to other tumors, gene expression profiling data on human cutaneous melanomas are scarce, and data with prognostic implication are entirely lacking. In order to better understand the progression of this tumor and to identify key genes involved in melanoma prognosis, we correlated gene-expression profiles with clinical outcome in a cohort of 83 patients with primary melanoma. Methods: A class comparison and class prediction analysis was performed to identify genes able to predict 4-years. distant metastasis free-survival in 58 primary melanomas with at least 4-years follow-up or intercurrent distant metastasis or death. Results were also validated at the protein level in an independent population of 176 primary melanomas with a median clinical follow-up of 8.5 years. Results: We identified a set of sequences discriminating between primary melanomas associated with good and poor prognosis. Some of these sequences correspond to key-genes in the regulation of replication origins firing, such as mini-chromosome maintenance genes and geminin. The prognostic value of overexpression of replication origins firing genes is independent from thickness, ulceration, age and sex. Conclusions: This study has identified key-genes associated with in vivo metastatic dissemination of cutaneous melanomas. Some of our data provide new diagnostic tools for the accurate diagnosis of melanoma and shed new light on the molecular mechanisms underlying poor prognosis in melanoma patients. As some of these molecules are currently under study as targets for therapy, our data can have significant impact on the development of new melanoma therapies. No significant financial relationships to disclose.
Later Results in the Use of Stramonium in Post-Encephalitic Syndrome*
Authors: A. L. Jacobson, F. Epplen
Journal: Annals of Internal Medicine (1930)

Article1 August 1930Later Results in the Use of Stramonium in Post-Encephalitic Syndrome*A. L. JACOBSON, M.D., F. EPPLEN, M.D.A. L. JACOBSON, M.D.Search for more papers by this author, F. EPPLEN, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-4-2-145 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptIt is now a year since we began using stramonium in the treatment of Post Encephalitic sequelae, the first report being read at the 1929 meeting of the American Medical Association in Portland. At that time ninety three per cent of our cases were of the Parkinsonian syndrome, largely because our material came chiefly from the King County Hospital, where a number of these cases had accumulated, and partly because certain cases in that hospital available to us had not been worked over carefully enough to determine that they were post encephalitic in nature, the patients being stowed away in...1 Unpublished paper read before the King County Medical Society Jan. 6, 1929. Google Scholar2 Jour. A.M.A. Vol. XCIII, 1929, p. 2030. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Seattle, Washington†Presented at the Minneapolis meeting of the American College of Physicians, February 10, 1930. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 August 1930Volume 4, Issue 2Page: 145-148 ePublished: 1 December 2008 Issue Published: 1 August 1930 PDF downloadLoading ...
Review: Adding tiotropium to ICSs alone or with LABAs improves pulmonary function in asthma
Authors: Diego J. Maselli, Jay I. Peters
Journal: Annals of Internal Medicine (2015)

ACP Journal Club16 June 2015Review: Adding tiotropium to ICSs alone or with LABAs improves pulmonary function in asthmaDiego J. Maselli, MD, Jay I. Peters, MDDiego J. Maselli, MDUniversity of Texas Health Science Center at San Antonio, San Antonio, Texas, USA (D.J.M., J.I.P.)Search for more papers by this author, Jay I. Peters, MDUniversity of Texas Health Science Center at San Antonio, San Antonio, Texas, USA (D.J.M., J.I.P.)Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/ACPJC-2015-162-12-005 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail Source CitationRodrigo GJ, Castro-Rodríguez JA. What is the role of tiotropium in asthma?: a systematic review with meta-analysis. Chest. 2015;147:388-96. https://pubmed.ncbi.nlm.nih.gov/25322075Clinical Impact RatingsGIM/FP/GP: Hospitalists: Allerg & Immunol: Pulmonology: References1. Meurs H, Oenema TA, Kistemaker LE, Gosens R. A new perspective on muscarinic receptor antagonism in obstructive airways diseases. Curr Opin Pharmacol. 2013;13:316-23. [PMID: 23643733] Google Scholar2. Wise RA, Anzueto A, Cotton D, et al; TIOSPIR Investigators. Tiotropium Respimat inhaler and the risk of death in COPD. N Engl J Med. 2013;369:1491-501. [PMID: 23992515] Google Scholar3. Chung KF, Wenzel SE, Brozek JL, et al. International ERS/ATS guidelines on definition, evaluation and treatment of severe asthma. Eur Respir J. 2014;43:343-73. [PMID: 24337046] Google Scholar Author, Article, and Disclosure InformationAffiliations: University of Texas Health Science Center at San Antonio, San Antonio, Texas, USA (D.J.M., J.I.P.)This article was published at Annals.org on 2 June 2015. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 16 June 2015Volume 162, Issue 12Page: JC5KeywordsAdverse eventsAsthmaPulmonary functionQuality of lifeSafetySystematic reviewsThorax ePublished: 16 June 2015 Issue Published: 16 June 2015 Copyright & PermissionsCopyright © 2015 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Abstract 709: Efficacy of Salmonella typhimurium A1-R on experimental breast cancer brain metastasis
Authors: Yong Zhang, Shinji Miwa, Nan Zhang, Robert M. Hoffman, Ming Zhao
Journal: Cancer Research (2014)

Abstract The aim of this study was to evaluate the efficacy of Salmonella typhimurium A1-R (A1-R) on breast cancer brain metastases. High brain-metastatic variants of murine 4T1 breast cancer cells expressing red fluorescent protein (RFP) were injected into the left ventricle of transgenic nude mice expressing nestin-driven green fluorescent protein (ND-GFP). ND-GFP mice express GFP in nascent blood vessels. At various time points, the tumors and vasculature in the brain were imaged by laser-scanning confocal and stereo fluorescence microscopy. Eighty percent of the cells that reached the brain extravasated and grew perivascularly; twenty percent of the cells, however, proliferated within the vasculature which may lead to thrombosis-like infarction of the brain parenchyma. Compared to the control group, mice treated with Salmonella typhimurium A1-R (A1-R) had significant inhibition of brain metastasis and increased survival (p&amp;lt;0.05). The results of the present study suggest the clinical potential of bacterial therapy of breast cancer brain metastasis. Citation Format: Yong Zhang, Shinji Miwa, Nan Zhang, Robert M. Hoffman, Ming Zhao. Efficacy of Salmonella typhimurium A1-R on experimental breast cancer brain metastasis. [abstract]. In: Proceedings of the 105th Annual Meeting of the American Association for Cancer Research; 2014 Apr 5-9; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2014;74(19 Suppl):Abstract nr 709. doi:10.1158/1538-7445.AM2014-709
A Miracle of St Nicholas
Authors: M. Therese Southgate
Journal: JAMA (1999)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
633. Dose-Dependent Gene Silencing by Lentivirus-Mediated RNA Interference (RNAi) in bcr-abl Positive Cells
Authors: Michaela Scherr, Karin Battmer, Arnold Ganser, Matthias Eder
Journal: Molecular Therapy (2004)

RNA interference (RNAi) describes a process of double-stranded RNA-dependent post-transcriptional gene silencing. This gene silencing is mediated by 21–23 nt small interfering RNAs (siRNAs) which induce sequence-specific mRNA degradation. Fusion-transcripts encoding oncogenic proteins may represent potential targets for a tumor-specific RNAi-approach. Recently, siRNAs have been shown to specifically inhibit expression of the bcr-abl oncogene essential for chronic myeloid and bcr-abl positive acute lymphoblastic leukemia (CML, ALL) in hematopoietic cell lines. Since RNAi triggered by a single siRNA application is only transient in mammalian cells potential anti-tumor effects are limited in the models studied so far. Gene transfer of transcription cassettes for suitable RNAi-triggers, however, can induce long-term gene silencing even in primary hematopoietic cells. Using lentiviral gene transfer to transcribe different shRNAs targeting the bcr-abl oncogene and to express red fluorescence protein (RFP) as a quantitative reporter to track cellular transduction we demonstrate that stable but not transient RNAi can efficiently deplete bcr-abl+human K562 and murine TonB cells. Importantly, killing of bcr-abl+cells depends on the dose of lentivirus used for transduction and correlates with the RFP-expression level of transduced cells. Furthermore, we show that lentiviral transduction of homogenous cell lines results in heterogenous cell populations in terms of lentiviral integrations, RFP-and siRNA expression, target gene silencing, and functional phenotype. Whereas transduced K562 cells with high RFP-expression are eradicated, a limited number of cells with lower RFP-expression and smaller number of lentiviral integrations may outgrow after longer periods of cell culture. Interestingly, these cells still show some reduction in bcr-abl mRNA levels, aberrant proliferation kinetics, and higher sensitivity to the Bcr-Abl kinase inhibitor STI571 as compared to controls. Furthermore, lentiviral gene transfer of anti bcr-abl shRNA into primary CML cells can inhibit colony formation of transduced CD34+progenitor cells by about 50%. These data demonstrate that lentivirus-mediated RNAi can induce high efficient and stable gene silencing depending on the number of lentiviral integrations in cell lines and in primary cells. Selection processes of gene modified cells, however, have implications for any potential therapeutic application and for functional genomic analysis based on gene transfer strategies to induce stable RNAi in mammalian cells.
Abstract 15023: Atherosclerosis Burden of the Aortic Valve and Aorta and Risk of Acute Kidney Injury After Transcatheter Aortic Valve Implantation
Authors: Philippe van Rosendael, Vasileios Kamperidis, Frank van der Kley, Spyridon Katsanos, Ibtihal Al Amri, Madelien Regeer, Arend de Weger, Nina Ajmone Marsan, Jeroen Bax, Victoria Delgado
Journal: Circulation (2014)

Background: Transcatheter aortic valve implantation (TAVI) involves both the manoeuvring of large catheters across a severely diseased aorta and the deployment of a prosthesis within a calcified aortic valve which may dislodge cholesterol crystals. Atheroembolic renal disease may be one of the pathophysiological mechanisms of acute kidney injury (AKI) complicating TAVI. Objective: To investigate the association between atherosclerotic burden and plaque characteristics of the aortic valve and thoracic aorta, evaluated with multi-detector computed tomography (MDCT), and the occurrence of AKI following TAVI. Methods: Aortic valve calcification, atherosclerosis burden and plaque characteristics of the descending thoracic aorta (DTA) were analysed in pre-procedural MDCT data of 210 TAVI patients (age 81±7.1 years, 51.4% men). The atherosclerotic burden was defined as the proportion of DTA segments with atherosclerosis (Figure). MDCT data were correlated with the occurrence of post-procedural AKI (defined using...
For and against: Clinical equipoise and not the uncertainty principle is the moral underpinning of the randomised controlled trial FOR AGAINST
Authors: C. Weijer
Journal: BMJ (2000)

# Clinical equipoise and not the uncertainty principle is the moral underpinning of the randomised controlled trial {#article-title-2}

The ethical basis for entering patients in randomised controlled trials is under debate. Some doctors espouse the uncertainty principle whereby randomisation to treatment is acceptable when an individual doctor is genuinely unsure which treatment is best for a patient. Others believe that clinical equipoise, reflecting collective professional uncertainty over treatment, is the soundest ethical criterion. Here doctors from two Canadian centres discuss their positions.

# For {#article-title-3}

On what ethical grounds may a physician offer trial participation to his or her patient? The answer seems to depend greatly on which side of the Atlantic you reside. In the United Kingdom, the uncertainty principle is widely endorsed. 1 2 However, in North America, clinical equipoise—reflecting collective uncertainty—is the dominant ethical basis.3 Which of these principles offers the preferred moral underpinning for the randomised controlled trial?

It is widely acknowledged that physicians have a primary duty to promote their patients' welfare. When physicians become investigators, however, other ends such as recruiting enough subjects and retaining them in the trial may conflict with this duty.4 How can the physician maintain fidelity to the patient and further the ends of a randomised controlled trial? The uncertainty principle offers an appealing solution to this problem.

Physicians who are convinced that one treatment is better than another for a particular patient cannot ethically choose at random which treatment to give, they must do what they think best for the patient. For this reason, physicians who feel they already know the answer cannot enter their patients into a trial. If they think, whether for a wise or silly reason, that they know the answer before the trial starts, they should not enter any patients.2

On the other hand, if the physician is uncertain about which treatment is best for a patient, offering the patient randomisation to equally …
Interactive case report: A 42 year old man with acute chest pain
Authors: G Sodeck
Journal: BMJ (2003)

Peter Hartl is a 42 year old man who enjoys working as an information technology specialist. He recently presented to his local emergency department with retrosternal chest pain. Two nights earlier, he had experienced similar symptoms associated with epigastric pain. On the advice of his wife, a nurse, he started self treatment with a proton pump inhibitor and sucralfate. The remedies had little effect, and during the next two days he experienced recurrent …
Abstract 1870: Differential Effects of Exercise Training and Beta-Blocker Therapy on Cardiac Function and Calcium Reuptake in a Genetic Model of Cardiomyopathy Induced by Sympathetic Hyperactivity
Authors: Natale Rolim, Jan B Bartholomeu, Katt C Mattos, Kaleizu T Rosa, Eduardo M Krieger, Jose Eduardo Krieger, Carlos Eduardo Negrao, Patricia C Brum
Journal: Circulation (2006)
Diseases of Workers
Authors: Bernardino Ramazzini
Journal: JAMA (1941)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal