THE EFFECTIVENESS OF AN ORAL VITAMIN K_1 IN CONTROLLING EXCESSIVE HYPOPROTHROMBINEMIA DURING ANTICOAGULANT THERAPY
Authors: S W COSGRIFF
Journal: Annals of Internal Medicine (1956)

Article1 July 1956THE EFFECTIVENESS OF AN ORAL VITAMIN K1 IN CONTROLLING EXCESSIVE HYPOPROTHROMBINEMIA DURING ANTICOAGULANT THERAPYSTUART W. COSGRIFF, M.D.STUART W. COSGRIFF, M.D.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-45-1-14 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptAnticoagulant therapy with the coumarin and indandione derivatives has been made less hazardous by the demonstration that Vitamin K1 and Vitamin K1 oxide1-5 produce a prompt reversal of excessive hypoprothrombinemia. Intravenous Vitamin K1 in dosage varying from 50 to 500 mg. of the oil-soluble emulsion will effect the prompt return of an elevated prothrombin time approximately to normal within 12 hours in most patients, frequently accompanied by cessation of bleeding when a hemorrhagic complication is present.The emulsion of Vitamin K1, originally prepared for intravenous administration, has been reported also to be effective by mouth.6-9Hanson7found that the prothrombin...Bibliography1. DavidsonMacDonald CSH: The effect of vitamin K1 oxide on hypoprothrombinemia induced by Dicumarol, New England J. Med. 229: 353, 1943. CrossrefGoogle Scholar2. JamesBennettScheinbergButler DFILPJJ: Clinical studies on Dicumarol hypoprothrombinemia and vitamin K preparations, Arch. Int. Med. 83: 632, 1949. CrossrefGoogle Scholar3. RehbeinJaretzkiHabif AADV: The response of Dicumarol-induced hypoprothrombinemia to vitamin K1 , Ann. Surg. 135: 454, 1952. CrossrefMedlineGoogle Scholar4. MillerHarveyFinch RWPCA: Antagonism of Dicumarol by vitamin K preparations, New England J. Med. 242: 211, 1950. CrossrefMedlineGoogle Scholar5. BlausteinShnayersonWallach ANR: Clinical use of a new anticoagulant, Am. J. Med. 14: 704, 1953. CrossrefMedlineGoogle Scholar6. Reid RA: The treatment of hypoprothrombinemia with orally administered vitamin K1 , Quart. Bull., Northwestern Univ. M. School 25: 292, 1951. Google Scholar7. HansonBarkerMann HHNWFD: Clinical experiences with 4-hydroxycoumarin anticoagulant No. 63 and the antagonistic effect of Menadione and vitamin K1 , Circulation 4: 844, 1951. CrossrefMedlineGoogle Scholar8. DuffGambleWillisHodgsonWilsonPolhemus IFJRPWPEWSJA: The control of excessive effect by anticoagulants, Ann. Int. Med. 43: 955, 1955. LinkGoogle Scholar9. Wright IS: Present status of anticoagulant therapy in the treatment of myocardial infarction; the use and misuse of anticoagulants; an evaluation of new anticoagulants, their indications and dosage, Ann. Int. Med. 43: 942, 1955. LinkGoogle Scholar10. Cosgriff SW: Hemorrhagic complications of hypoprothrombinemic anticoagulant therapy, in preparation. Google Scholar11. Shapiro S: Hyperprothrombinemia, a premonitory sign of thromboembolism (description of a method), Exper. Med. and Surg. 2: 103, 1944. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: New York, N. Y.*Received for publication March 17, 1956.From the Department of Medicine, Columbia University, College of Physicians and Surgeons, and the Presbyterian Hospital, New York, N. Y.Requests for reprints should be addressed to Stuart W. Cosgriff, M.D., Department of Medicine, Columbia University, College of Physicians and Surgeons, 620 West 168th Street, New York 32, N. Y. 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A prospective, randomized, open studyAnticoagulation TherapyManagement and dosing of warfarin therapyVitamin K to Reverse Excessive Anticoagulation: A Review of the LiteratureProspective Evaluation of Anticoagulant Reversal With Oral Vitamin K1 While Continuing Warfarin Therapy UnchangedOral AnticoagulantsA technique to prevent bleeding following tonsillectomy and adenoidectomyORAL AND INTRAVENOUS ESTROGENS IN THE TREATMENT AND PREVENTION OF BLEEDING ASSOCIATED WITH LONG-TERM ANTICOAGULANT THERAPYHemorrhagic Diathesis during Pregnancy Due to Unexplained Lack of Vitamin K A case reportEXPERIENCE WITH THE ANTICOAGULANT, MARCUMAR*ROBERT E. ENSOR, M.D., H. RAYMOND PETERS, M.D., F.A.C.P.Massachusetts Medical Society 1 July 1956Volume 45, Issue 1Page: 14-22KeywordsAnticoagulant therapyCoumarinsHemorrhageHospital medicineOral administrationProthrombin timeSurgeons Issue Published: 1 July 1956 PDF downloadLoading ...