GENERALIZED OSTEOSCLEROSIS ASSOCIATED WITH DIABETES INSIPIDUS AND NEUROLOGIC SYMPTOMS
Authors: D W JOHNSTON
Journal: Annals of Internal Medicine (1957)

Case Reports1 March 1957GENERALIZED OSTEOSCLEROSIS ASSOCIATED WITH DIABETES INSIPIDUS AND NEUROLOGIC SYMPTOMSD. W. JOHNSTON, M.D.D. W. JOHNSTON, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-46-3-619 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptINTRODUCTIONDiffuse osteosclerosis is of varied etiology. Its pathogenesis is poorly understood. The clinical and x-ray features have become stereotyped in most cases, but do not as a rule suggest the etiology.The conditions in which osteosclerosis, with or without hyperostosis, is seen, are:1. Hypothyroidism.2. Postoperative hyperparathyroidism.3. Neoplasia, especially carcinoma of the prostate.4. Hypervitaminosis D and, more rarely, A.5. Fluorosis.6. Phosphorus poisoning.The known causes of overgrowth of periosteal bone are:1. Syphilis.2. Healed scurvy.3. Healed rickets.The primary disorders of unknown etiology which cause increased density of bone are:1. Paget's...Bibliography1. HingeMenck-Thygesen JP: A case of generalized osteosclerosis, Am. J. Roentgenol. 66: 595, 1951. Google Scholar2. Mellanby E: Skeletal changes affecting the nervous system produced in young dogs by diets deficient in vitamin A, J. Physiol. 99: 467, 1941. CrossrefMedlineGoogle Scholar3. Brailsford JE: Radiology of joints and bones, 4th Ed., 1948, The Williams & Wilkins Co., Baltimore, p. 552. Google Scholar4. McPeak CN: Osteopetrosis, Am. J. Roentgenol. 36: 816, 1936. Google Scholar5. Fairbank T: Atlas of general affections of the skeleton, 1951, The Williams & Wilkins Co., Baltimore, p. 33. Google Scholar6. JacksonAlbrightDrewryHanelinRuben WPFGJMI: Metaphyseal dysplasia, epiphyseal dysplasia, diaphyseal dysplasia and related conditions. I. Familial metaphyseal dysplasia and craniometaphyseal dysplasia, Arch. Int. Med. 94: 871, 1954. CrossrefGoogle Scholar7. Wilkie J: Fluorine osteosclerosis, Brit. J. Radiol. 13: 213-217, 1940. CrossrefGoogle Scholar8. WeinmanSicher JPH: Bone and bones, 1947, C. V. Mosby Co., St. Louis, p. 277. Google Scholar9. FranklinMatheson ELI: Melorheostosis, Brit. J. Radiol. 15: 185, 1942. CrossrefGoogle Scholar10. Kibby SV: Melorheostosis, Radiology 37: 62, 1941. CrossrefGoogle Scholar11. Joseph SW: Clinical Conference at Brooke Army Hospital, Fort Sam Houston, Texas, J. Pediat. 46: 233, 1955. MedlineGoogle Scholar12. Michaelis LA: Engelmann's disease, Proc. Roy. Soc. Med. (Orthopedic Section) 42: 271, 1949. MedlineGoogle Scholar13. StrangeMcDowell RFHB: A case of Engelmann's disease, J. Bone and Joint Surg. 32-B: 38, 1950. CrossrefGoogle Scholar14. JacksonHanelinAlbright WPJF: Metaphyseal dysplasia, epiphyseal dysplasia, diaphyseal dysplasia and related conditions. III. Progressive diaphyseal dysplasia, Arch. Int. Med. 94: 871, 1954. CrossrefGoogle Scholar15. Anderson FG: Engelmann's disease, Brit. J. Radiol. 26: 603, 1953. CrossrefMedlineGoogle Scholar16. SidburySidbury JBJB: Infantile cortical hyperostosis, New England J. Med. 250: 309, 1954. CrossrefMedlineGoogle Scholar17. Weber FP: Osteosclerotic changes due to chronic infection or neoplastic infiltration (secondary marble bones), Lancet 1: 386, 1955. CrossrefGoogle Scholar18. WindholzFoster FSE: Generalized osteosclerosis in disorders of blood formation, Stanford M. Bull. 5: 75, 1947. MedlineGoogle Scholar19. SharnoffBelskyMelton JGHJ: Plasma cell leukemia or multiple myeloma with osteosclerosis, Am. J. Med. 17: 582, 1954. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Fort Worth, Texas*Received for publication November 12, 1955.From the Department of Medicine at the Veterans Administration Hospital, McKinney, Texas, and University of Texas Southwestern Medical School, Dallas, Texas.Requests for reprints should be addressed to Dewey W. Johnston, M.D., 901 West Leuda, Fort Worth, Texas. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byDiabetes, Diabetic Complications, and Phosphate Toxicity: A Scoping Review 1 March 1957Volume 46, Issue 3Page: 619-628KeywordsBone densityEtiologyHospital medicineHyperparathyroidismHypothyroidismLesionsPathogenesisPhosphorusSpineSyphilis ePublished: 1 December 2008 Issue Published: 1 March 1957 PDF downloadLoading ...