FURTHER OBSERVATIONS ON PATIENTS WITH SEVERE HYPERTENSION SUBJECTED TO ADRENAL RESECTION AND SYMPATHECTOMY
Authors: W A JEFFERS, H A ZINTEL, A G HILLS, J H HAFKENSCHIEL, S B LANGFELD, A M SELLERS, C C WOLFERTH
Journal: Annals of Internal Medicine (1954)

Article1 August 1954FURTHER OBSERVATIONS ON PATIENTS WITH SEVERE HYPERTENSION SUBJECTED TO ADRENAL RESECTION AND SYMPATHECTOMYWILLIAM A. JEFFERS, F.A.C.P., HAROLD A. ZINTEL, F.A.C.S., A. GORMAN HILLS, JOSEPH H. HAFKENSCHIEL, STEPHEN B. LANGFELD, ALFRED M. SELLERS, CHARLES C. WOLFERTH, F.A.C.P.WILLIAM A. JEFFERS, F.A.C.P., HAROLD A. ZINTEL, F.A.C.S., A. GORMAN HILLS, JOSEPH H. HAFKENSCHIEL, STEPHEN B. LANGFELD, ALFRED M. SELLERS, CHARLES C. WOLFERTH, F.A.C.P.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-41-2-221 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptINTRODUCTIONIt has now been four years since our first patient was submitted to adrenal resection and three years since the first report to this College.1 We are aware that it may well require more than 10 years of careful study before the merits of this type of surgical approach can be properly evaluated. Meanwhile, the need for less drastic and more effective means of altering the course of severe hypertension remains obvious.As indicated previously,2, 3our interest has become focused upon the effects of total or subtotal adrenal resection combined with a limited Adson-type sympathectomy. Our immediate objective...Bibliography1. WolferthJeffersLukensZintelHafkenschiel CCWAFDHAJH: Observations on the results of subtotal adrenalectomy in the treatment of severe, otherwise intractable hypertension and their bearing on the mechanism by which hypertension is maintained, Ann. Int. Med. 35: 8, 1951. LinkGoogle Scholar2. JeffersZintelHafkenschielHillsSellersWolferth WAHAJHAGAMCC: The clinical course, following adrenal resection and sympathectomy, of 82 patients with severe hypertension, Ann. Int. Med. 39: 254, 1953. LinkGoogle Scholar3. JeffersZintelHafkenschielHillsSellersWolferth WAHAJHAGAMCC: Evaluation of adrenal resection and sympathectomy in ninety-nine persons with hypertension, J. A. M. A. 153: 1502, 1953. CrossrefMedlineGoogle Scholar4. ThornHarrisonMerrillCriscitielloFrawleyFinkenstaedt GWJHJPMGTFJT: Clinical studies in bilateral complete adrenalectomy in patients with severe hypertensive vascular disease, Ann. Int. Med. 37: 972, 1952. LinkGoogle Scholar5. Bowers RF: Bilateral adrenalectomy for severe hypertension, J. A. M. A. 154: 394, 1954. CrossrefMedlineGoogle Scholar6. SmithwickThompson RHJE: Splanchnicectomy for essential hypertension, J. A. M. A. 152: 1501, 1953. CrossrefMedlineGoogle Scholar7. EvelynAlexanderCooper KAFSR: Effect of sympathectomy on blood pressure in hypertension, J. A. M. A. 140: 592, 1949. CrossrefMedlineGoogle Scholar8. HafkenschielFriedlandZintel JHCKHA: The blood flow and oxygen consumption of the brain in patients with essential hypertension before and after adrenalectomy, J. Clin. Investigation 33: 57, 1954. CrossrefMedlineGoogle Scholar9. HillsVenningDohanWebsterRichardson AGEHFCGDEM: Pregnancy and adrenocortical function. Endocrine studies of pregnancy occurring in two adrenal-deficient women, J. Clin. Investigation, to be published. Google Scholar10. HillsChalmersWebsterRosenthal AGTMGDO: Adrenal cortical regulation of the distribution of water and electrolytes in the human body, J. Clin. Investigation 32: 1236, 1953. CrossrefMedlineGoogle Scholar11. HillsWebsterRosenthalDohanRichardsonZintelJeffers AGGDOFCEMHAWA: Quantitative evaluation of primary adrenal cortical deficiency in man, Am. J. Med. 16: 328, 1954. CrossrefMedlineGoogle Scholar12. GrimsonOrgainAndersonD'Angelo KSESBGJ: Total thoracic and partial to total lumbar sympathectomy, splanchnicectomy and celiac ganglionectomy for hypertension, Ann. Surg. 138: 532, 1953. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Philadelphia, Pennsylvania*Presented at the Thirty-Fifth Annual Session of the American College of Physicians, Chicago, Illinois, April 9, 1954.From the Edward B. Robinette Foundation, Medical Clinic and the Surgical Service of the Hospital of the University of Pennsylvania.This investigation was supported in part by research grants from The National Heart Institute, the U. S. Public Health Service (H-338), the Squibb Institute of Medical Research, Eli Lilly and Company, Ciba Pharmaceutical Products, Inc., and Merck and Company, Inc. Nextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byResults of sympathectomy and adrenalectomyObservations of human adrenal cortical deficiencyThe Management of Hypertensive Cardiovascular DiseaseSUBTOTAL ADRENALECTOMY IN CUSHING'S SYNDROME*HERBERT W. COONE, M.D., F.A.C.P., JAMES W. HUMPHREYS JR., M.D., M.S. (Surgery), F.A.C.S.Die AdrenalektomiePhysiologic Problems Related to the Surgery of HypertensionEssential Hypertension: A Selected Review and CommentaryAdrenalectomy for Hypertension 1 August 1954Volume 41, Issue 2Page: 221-231KeywordsAnesthesiologyHealth services researchHeartHospitalsHypertensionMedical servicesMortalityResearch grantsSurgical resectionSympathectomy Issue Published: 1 August 1954 Copyright & PermissionsCopyright, 1954, by The American College of PhysiciansPDF downloadLoading ...