tbuckley/cabot-search huggingface dataset:
A Favorable Response in Tongue Cancer to Arterial Infusion Chemotherapy
Authors: Robert D Sullivan
Journal: JAMA (1962)

THE CURRENT INTEREST in regional cancer chemotherapy has been stimulated by several factors: (1) Although many cancer chemotherapeutic compounds have been developed and are currently undergoing clinical investigation in patients with far-advanced cancer, most reports have shown that the<i>systemic</i>administration of these agents has not resulted in significant practical value in the management of most common forms of cancer. (2) Many common forms of cancer, although beyond conventional therapy, remain localized throughout their evolution and produce symptoms and death from the locally confined, yet uncontrolled, growths. Regional cancer chemotherapy has been developed in an effort to increase the regional effect of antitumor agents in patients with advanced cancer whose tumors are within the distribution of accessible arteries. A method of regional administration of anticancer drugs has been reported which consists of the continuous arterial administration of an antimetabolite through catheters inserted into the major vessels supplying a tumor-bearing area.
Reply to Bastid et al.
Authors: H. Kakutani, S. Hino, H. Tajiri
Journal: Endoscopy (2005)

We are grateful to Bastid and colleagues for their interest in our article. They suggest that in experienced hands, percutaneous color Doppler ultrasonography is a simple, low-cost technique that is very effective and does not require sedation. Unfortunately, we do not have access to their published article, as it is written in French.
Contemplating the White Coat
Authors: David G. De Marco
Journal: Annals of Internal Medicine (1999)

Letters6 July 1999Contemplating the White CoatDavid G. De Marco, SJ, MDDavid G. De Marco, SJ, MDLoyola University Chicago; Chicago, IL 60660 (De Marco)Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-131-1-199907060-00028 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:Wear (1) and Branch (2) have contributed thoughtfully to the discussion of values in medicine and their inculcation. Wear rightly argues that the white coat ceremony, or ritual, and the subseqeunt wearing of the white coat by student-physicians may hinder the development of the self-reflective skills critical for the cultivation of virtues intrinsic to the practice of medicine. She recommends “creating new rituals” around “community-based sites” where caregivers might model for student-physicians the virtues in medicine. Branch, on the other hand, suggests the importance of creating a forum for reflection among students who sense their values eroding ...References1. Wear D. On white coats and professional development: the formal and the hidden curricula. Ann Intern Med. 1998;129:734-7. LinkGoogle Scholar2. Branch WT. Deconstructing the white coat [Editorial]. Ann Intern Med. 1998;129:740-2. LinkGoogle Scholar3. Aristotle. Nicomachean Ethics. Translated by Martin Ostwald. Englewood Cliffs, NJ: Prentice Hall; 1962. Google Scholar Author, Article, and Disclosure InformationAffiliations: Loyola University Chicago; Chicago, IL 60660 (De Marco) PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoOn White Coats and Professional Development: The Formal and the Hidden Curricula Delese Wear Contemplating the White Coat Stewart P. Seigle Contemplating the White Coat Mark M. Paulsen Contemplating the White Coat William T. Branch Jr. Metrics Cited byDiscourses of student orientation to medical education programsCloak of compassion, or evidence of elitism? An empirical analysis of white coat ceremonies 6 July 1999Volume 131, Issue 1Page: 73KeywordsCaregivers Issue Published: 6 July 1999 Copyright & PermissionsCopyright © 1999 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
[461] ACUTE HEPATITIS C INFECTION IN HIV-INFECTED PATIENTS: LOW RATE OF SPONTANEOUS CLEARANCE AND WEAK HEPATITIS C VIRUS-SPECIFIC T CELL RESPONSES
Authors: A. Schnuriger, S. Dominguez, C. Katlama, M.A. Valantin, A. Simon, L. Slama, Z. Ouazene, P.M. Girard, B. Autran, V. Thibault
Journal: Journal of Hepatology (2007)
Abstract 3828: Potent curcumin analogues inhibit pancreatic cancer cell growth and angiogenesis
Authors: Ganji Purnachandra Nagaraju, Shijun Zhu, Roberto Diaz, Mamoru Shoji, Bassel F. El-Rayes
Journal: Cancer Research (2012)

Abstract Background: Curcumin, a component of turmeric, has demonstrated anti-cancer properties mediated through inhibition of NF-κB in preclinical models. In clinical trials, curcumin failed to demonstrate activity against pancreatic cancer. The pharmacologic properties, low absorption, and low potency of curcumin may account for this discrepancy between preclinical and clinical results. Using the curcumin molecular model, our group synthesized over 100 analogs. Of these analogs, EF31 and UBS109 demonstrated higher potency in squamous cell cancer xenograft models as well as inhibition of NF-κB signaling pathways. Based on this preclinical data, we hypothesized that these analogs EF-31 and UBS-109 would be more effective in inhibiting growth of pancreatic cell lines than curcumin. Methods: MiaPaCa-2 and PANC-1 cell lines were used in the experiments. Cells were cultured and then treated with nothing (control), curcumin, UBS-109, EF-31, 5FU, or combination. Cell proliferation was evaluated using XTT assay. Western blot was used to evaluate effects on HSP90, HIF-1α, and VEGF levels. Angiogenic effects were measured by tube formation and chicken egg chorioallantoic membrane (Egg CAM) assays. Results: UBS-109 and EF-31 demonstrated significantly improved inhibition of cell proliferation as compared to curcumin. UBS-109 and EF-31 potentiated the growth inhibitory effects of 5FU. UBS-109 and EF-31 resulted in significant inhibition of expression of protein and mRNA for HSP90 and HIF-1α as compared to curcumin. In turn, UBS-109 and EF-31 significantly inhibited VEGF protein and mRNA expression resulting in inhibition of HUVEC tube formation in vitro and also inhibited angiogenesis in vivo using the Egg CAM assay. Conclusion: UBS-109 and EF-31 are more potent analogs of curcumin. Preliminary data demonstrate potentiation of chemotherapy effects as well as antiangiogenic effects. Evaluating UBS-109 and EF-31 in patients with pancreatic cancer is a rational approach to target HSP90 and HIF-1α in this disease. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 103rd Annual Meeting of the American Association for Cancer Research; 2012 Mar 31-Apr 4; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2012;72(8 Suppl):Abstract nr 3828. doi:1538-7445.AM2012-3828
Shredding of rejected manuscripts
Authors: S. Lock
Journal: BMJ (1984)

H influenzae, including 1-lactamase producing strains, are cefuroxime, cefotaxime, latamoxef, and ceftazidime.Experience with cefuroxime in treating H influenzae meningitis suggests that it should be a suitable alternative to treat such infections.23Case clustering studies and epidemiological surveys have underlined the communicability of H influenzae infection.242'In the United States whenever meningitis occurs chemoprophylaxis with rifampicin is now recommended for the index patient, and households with children below 4 years of age, as well as for staff and children in day centres.26The evidence that this is necessary for infections other than meningitis is lacking, though secondary cases of H influenzae infection may complicate non-meningitic primary infections.27Prevention through immunisation remains an attractive hope, with several vaccines as candidates, though this leap into the realms of practical preventive medicine still appears distant."-30
The transcription factor STAT5 is critical in dendritic cells for the development of TH2 but not TH1 responses
Authors: Bryan D Bell, Masayuki Kitajima, Ryan P Larson, Thomas A Stoklasek, Kristen Dang, Kazuhito Sakamoto, Kay-Uwe Wagner, Daniel H Kaplan, Boris Reizis, Lothar Hennighausen, Steven F Ziegler
Journal: Nature Immunology (2013)
Right Ventricular Performance and Mass by Use of Cine MRI Late After Atrial Repair of Transposition of the Great Arteries
Authors: Christine H. Lorenz, Eloisa S. Walker, Thomas P. Graham, Thomas A. Powers
Journal: Circulation (1995)

Background The long-term adaptation of the right ventricle after atrial repair of transposition of the great arteries (TGA) remains a subject of major concern. Cine magnetic resonance imaging (MRI), with its tomographic capabilities, allows unique quantitative evaluation of both right and left ventricular function and mass. Our purpose was to use MRI and an age-matched normal population to examine the typical late adaptation of the right and left ventricles after atrial repair of TGA. Methods and Results Cine MRI was used to study ventricular function and mass in 22 patients after atrial repair of TGA. Images were obtained in short-axis sections from base to apex to derive normalized right and left ventricular mass (RVM and LVM, g/m 2 ), interventricular septal mass (IVSM, g/m 2 ), RV and LV end-diastolic volumes (EDV, mL/m 2 ), and ejection fractions (EF). Results 8 to 23 years after repair were compared with analysis of 24 age- and sex-matched normal volunteers and revealed markedly elevated RVM, decreased LVM and IVSM, normal RV size, and only mildly depressed RVEF. Only 1 of 22 patients had clinical RV dysfunction, and this patient had increased RVM. Conclusions Cine MRI allows quantitative evaluation of both RV and LV mass and function late after atrial repair of TGA. Longitudinal studies that include these measurements should prove useful in determining the mechanism of late RV failure in these patients. On the basis of these early data, inadequate hypertrophy does not appear to be the cause of late dysfunction in this patient group.
Estrogens and development.
Authors: J A McLachlan, R R Newbold
Journal: Environmental Health Perspectives (1987)

The normal development of the genital organs of mammals, including humans, is under hormonal control. A role for the female sex hormone estrogen in this process is still unclear. However, exposure of experimental animals or humans to the potent exogenous estrogen, diethylstilbestrol (DES), results in persistent differentiation effects. Since many chemicals in the environment are weakly estrogenic, the possibility of hormonally altered differentiation must be considered.
A CRITICAL COMPARISON OF THE T-1824 DYE AND IODINATED ALBUMIN METHODS FOR PLASMA VOLUME MEASUREMENT 1
Authors: Alvin L. Schultz, James F. Hammarsten, Ben I. Heller, Richard V. Ebert
Journal: Journal of Clinical Investigation (1953)

The T-1824 dye method for plasma volume measurement has been subjected to much criticism.The validity of its use as a tagged protein dilu- tion method has been questioned.One of the major criticisms has been that part of the injected dye is rapidly removed from the plasma before binding with protein occurs.This objection does not apply to the use of human serum albumin tagged with radioactive iodine before injection.Comparison of the two methods has given conflict- ing results (1-3).The present study was undertaken to clarify the relationship between the dye and the iodinated albumin methods for the meas- urement of the plasma volume. METHODSA modification of the T-1824 dye method described by Gibson and Evelyn (4) was used in the present study.Two cc. of an aqueous solution containing 10 mg. of T-1824 dye 2 was measured in a calibrated syringe and injected intravenously.Blood samples were then drawn at 10- minute intervals for 1 hour by interrupting a continuous, slow, intravenous infusion of isotonic saline.The blood samples were collected in 4 cc.hematocrit tubes containing 1.25 mg. of heparin.The plasma was separated by cen- trifugation for 30 minutes at 3500 r.p.m.The plasma con- taining dye was compared with a blank plasma sample drawn just prior to the dye injection.An Evelyn color- imeter with a 620 millimicra filter was used.The optical densities were plotted against time on semilogarithmic paper and extrapolated to zero time (CO).The optical density of a 1: 1000 dilution of T-1824 dye in plasma was determined (K).The K factor of the dye was deter- mined individually in the plasma of each of 21 normal subjects.The mean value for the individual K factors was 0.351 (S.D. 0.009).This mean K was then used
INDICATIONS FOR SURGICAL INTERVENTION IN INFECTIONS OF THE BILIARY TRACT.
Authors: JOHN B. DEAVER
Journal: JAMA (1906)

Boston, said that he has several times transferred sick children on his service on the Boston Floating Hospital from the ordinary ward to the wards whose atmosphere was cool and freed from excessive moisture and *ias seen marked improvement follow the change.The im- provement to be sure has sometimes been only temporary, but frequently it has been permanent.His experience very de- cidedly substantiates Dr. Pisek's views in regard to the influ- ence cf temperature and the degree of humidity on the occur- rence and course of disease in young children.Dr. G. R. Pisek, New York, said that this paper in a meas- ure may answer some of the questions asked of Dr. Northrop concerning his out-of-door treatment-whether the good effects are due to the oxygen or to the cold air?In winter, the humidity is less and the circulation of air greater.We can absorb just so much oxygen and it does not make much differ- ence whether we give compressed air or forced oxygen to children; but the out-of-door-air plus the cold or the lowered humidity is perhaps that which gives the good results in the winter as against the summer.In the use of the salines in fever, spoken of by Dr. J. Madison Taylor, the fever may be reduced by the evaporation of perspiration induced and the results show the good effects of the salines.Dr. Pisek said that he is glad to know about the cooling plant of the Bos- ton Floating Hospital.He thinks that this is just the thing needed in solving the problem of taking care of sick children in summer.Relative to Dr. Rotch's remarks about taking the children off of milk feeding, he said that he has noticed that they do not nurse so long in the hot summer days and that giving them sterile water before nursing has seemed to benefit.
Provision of antigen and CD137 signaling breaks immunological ignorance, promoting regression of poorly immunogenic tumors
Authors: Ryan A. Wilcox, Dallas B. Flies, Gefeng Zhu, Aaron J. Johnson, Koji Tamada, Andrei I. Chapoval, Scott E. Strome, Larry R. Pease, Lieping Chen
Journal: Journal of Clinical Investigation (2002)

Treatment of advanced, poorly immunogenic tumors in animal models, considered the closest simulation available thus far for conditions observed in cancer patients, remains a major challenge for cancer immunotherapy. We reported previously that established tumors in mice receiving an agonistic mAb to the T cell costimulatory molecule 4-1BB (CD137) regress due to enhanced tumor antigen–specific cytotoxic T lymphocyte responses. In this study, we demonstrate that several poorly immunogenic tumors, including C3 tumor, TC-1 lung carcinoma, and B16-F10 melanoma, once established as solid tumors or metastases, are refractory to treatment by anti–4-1BB mAb. We provide evidence that immunological ignorance, rather than anergy or deletion, of tumor antigen–specific CTLs during the progressive growth of tumors prevents costimulation by anti–4-1BB mAb. Breaking CTL ignorance by immunization with a tumor antigen–derived peptide, although insufficient to stimulate a curative CTL response, is necessary for anti–4-1BB mAb to induce a CTL response leading to the regression of established tumors. Our results suggest a new approach for immunotherapy of human cancers.
Incidence of sarcoidosis in the Isle of Man.
Authors: S A Parkes, S B Baker, R E Bourdillon, C R Murray, M Rakshit, J W Sarkies, J P Travers, E W Williams
Journal: Thorax (1985)

The incidence of sarcoidosis in a clearly defined island community has been determined in a seven year study. Special efforts were made to identify all cases, including those presenting to their general practitioners with only minor symptoms. A mean incidence of 14.7 per 100 000 per annum has been found in the years 1977-83 compared with an annual incidence of 3.5 per 100 000 in the preceding 15 years, when no specific attempts were made to identify sufferers from sarcoidosis. The lower figure is similar to the reported incidence in the United Kingdom and the difference is considered to be due to increased detection of cases during the study period. These findings suggest that a large proportion of cases of sarcoidosis in a general population may not be recorded in a registration system.
THE VITAL CAPACITY OF THE LUNGS IN PNEUMONIA
Authors: JOHN H. ARNETT
Journal: JAMA (1925)

The vital capacity was defined by Hutchinson<sup>1</sup>as the quantity of air a person is capable of expiring after the deepest possible inspiration. Although many thoracic diseases are known to diminish the vital capacity, in few, if any, is the reduction more striking than in pneumonia. The sudden fall of the vital capacity in pneumonia and the subsequent increase incident to uncomplicated convalescence are sufficiently uniform to be of diagnostic significance. The present paper, based on a study of thirty-two cases of pneumonia in the medical wards of the University Hospital, will deal with the diagnostic and prognostic aspects of the vital capacity in this disease. Unfortunately, wide variations in the vital capacity are to be found in persons of the same weight and stature, so that as Arnett and Kornblum<sup>2</sup>have pointed out, little assistance can be expected from this test in the early diagnosis of pulmonary
EGFR and HER2 Gene Copy Number and Response to First-Line Chemotherapy in Patients with Advanced Non-small Cell Lung Cancer (NSCLC)
Authors: Federico Cappuzzo, Claudio Ligorio, Luca Toschi, Elisa Rossi, Rocco Trisolini, Daniela Paioli, Elisabetta Magrini, Giovanna Finocchiaro, Stefania Bartolini, Alessandra Cancellieri, Fred R. Hirsch, Lucio Crino, Marileila Varella-Garcia
Journal: Journal of Thoracic Oncology (2007)
Reimbursement Policy and Androgen-Deprivation Therapy for Prostate Cancer
Authors: Vahakn B. Shahinian, Yong-Fang Kuo, Scott M. Gilbert
Journal: New England Journal of Medicine (2010)

The Medicare Modernization Act led to moderate reductions in reimbursement for androgen-deprivation therapy (ADT) for prostate cancer, starting in 2004 and followed by substantial changes in 2005. We hypothesized that these reductions would lead to decreases in the use of ADT for indications that were not evidence based.Using the Surveillance, Epidemiology, and End Results (SEER) Medicare database, we identified 54,925 men who received a diagnosis of incident prostate cancer from 2003 through 2005. We divided these men into groups according to the strength of the indication for ADT use. The use of ADT was deemed to be inappropriate as primary therapy for men with localized cancers of a low-to-moderate grade (for whom a survival benefit of such therapy was improbable), appropriate as adjuvant therapy with radiation therapy for men with locally advanced cancers (for whom a survival benefit was established), and discretionary for men receiving either primary or adjuvant therapy for localized but high-grade tumors. The proportion of men receiving ADT was calculated according to the year of diagnosis for each group. We used modified Poisson regression models to calculate the effect of the year of diagnosis on the use of ADT.The rate of inappropriate use of ADT declined substantially during the study period, from 38.7% in 2003 to 30.6% in 2004 to 25.7% in 2005 (odds ratio for ADT use in 2005 vs. 2003, 0.72; 95% confidence interval [CI], 0.65 to 0.79). There was no decrease in the appropriate use of adjuvant ADT (odds ratio, 1.01; 95% CI, 0.86 to 1.19). In cases involving discretionary use, there was a significant decline in use in 2005 but not in 2004.Changes in the Medicare reimbursement policy in 2004 and 2005 were associated with reductions in ADT use, particularly among men for whom the benefits of such therapy were unclear. (Funded by the American Cancer Society.).
Lymphogranuloma Venereum Conjunctivitis with a Marginal Corneal Perforation
Authors: Delyse R. Buus, Stephen C. Pflugfelder, Julius Schachter, Darlene Miller, Richard K. Forster
Journal: Ophthalmology (1988)

The authors have recently treated a case of Parinaud's oculoglandular syndrome due to Chlamydia trachomatis serotype L2, a causative agent of lymphogranuloma venereum (LGV). The ocular manifestations included a mixed papillary-follicular conjunctivitis with fleshy superior timbal lesions in both eyes. A superior marginal corneal perforation requiring a therapeutic corneal graft was present in the right eye. The patient had vaginitis, inguinal lymphadenopathy, a history of Sjögren's syndrome, and seropositivity to human immunodeficiency virus (HIV). The ocular disease resolved completely after 6 weeks of oral tetracycline therapy.
Scintigraphic Findings of Osteomyelitis After Intraosseous Infusion in a Child
Authors: BRUCE J. BARRON, HUYEN D. TRAN, LAMK M. LAMKI
Journal: Clinical Nuclear Medicine (1994)

A case of unilateral tibial osteomyelitis in a 20-month-old child after bilateral intraosseous infusion (IOI) needle placement is presented. A review of the indications, potential complications, and scan findings is discussed. This case also shows the lack of significant uptake in the noninfected side, suggesting that a three-phase bone scan is of value in differentiating reactive bone from infected bone In patients with IOI.
Acute polymyopathy during total parenteral nutrition.
Authors: P M Stewart, W J Hemsley
Journal: BMJ (1981)

inflammatory damage to peripheral nerves is caused by the infective agent and its toxins or by an immunological response triggered by them has long been debated.Much evidence supports an immunological cause for this condition, but it is not clear whether our patient's neuropathy was of this type or a specific feature of legionnaires' disease.Kennedy et al3 found neurophysiological evidence for an acute axonal neuropathy in five patients with legionnaires' disease, though clinical manifestations were evident in only a single case.Their findings and the small rise in cerebrospinal fluid protein concentration in our patient offer some support for a specific neuropathy accompany- ing legionnaires' disease.We thank Dr A Pringle for permission to report this case.
Role of acid attack in the in vitro bioactivity of a glass-ceramic of the 3CaO·P2O5-CaO·SiO2-CaO·MgO·2SiO2 system
Authors: J Roman, A.J Salinas, M Vallet-Regi, J.M Oliveira, R.N Correia, M.H Fernandes
Journal: Biomaterials (2001)