tbuckley/cabot-search huggingface dataset:
Memorable patients: The milkman of human kindness
Authors: R. Baker
Journal: BMJ (1998)

“You'll have to give me loads of that sedation, Doc. I used to drink a lot of camels' milk.” The patient was from north Africa but had lived in Britain for some years (%). I gave him my best knowing and reassuring smile, nodded, and injected my usual 4mg of midazolam before his fibreoptic bronchoscopy.

Five minutes later, he was grinning up at me, saying, “I'll need some more of that stuff. …
Atypical variants of clinical course of sarcoidosis
Authors: Vadimir Romanov
Journal: European Respiratory Journal (2014)

Since 1974 till 2013 we observed around 3000 patients with proven sarcoidosis. Investigation included anamnesis, chest CT, US of abdomen, bronchoscopy with BAL and TBLB or VATS. All cases were confirmed by morphology. Non-typical variants of disease were observed in 66 cases (3,3%).  Of them, further variants of clnical course were observed:  sarcoidosis with symptoms of lymphoid proliferation (subfebrile fever, spleno- and hepatomegaly, peripheral lymphnodes impairment) – 12 cases.  sarcoidosis with progressive pneumosclerosis and growing breathlessness (like in IPF cases) – 26 cases.  Infiltrative and pneumonic forms of disease with conglomerates and atelectases in the lung (like in infiltrative TB) – 28 cases.  Duration of observation over our patients reached 17 years in maximal. All cases were with recurrent form of disease. Overall mortality in studied cohort reached 13.6 % (9 cases).  Conclusion: All atypical variants of clinical flow of sarcoidosis were prognostically non-favourable. All these cases need advanced investigation and prolonged and intensive treatment.
Embryology of Testicular Teratomas in Strain 129 Mice&lt;xref ref-type="fn" rid="FN1"&gt;2&lt;/xref&gt;
Authors: Leroy C. Stevens
Journal: JNCI Journal of the National Cancer Institute (1959)

Based on observations of teratomas in strain 129 infant mice, the following sequence of development is proposed: The most primitive tumors are composed of clusters of embryonal cells with germ cells interspersed. Some of these cells form epithelial vesicles surrounding pools of blood and cellular debris. Approximately half these vesicles are morphologically different from the other half, signifying the formation of layers of cells homologous to ectoderm and endoderm. Mesoderm surrounds the vesicles. Ectoderm is transformed into neuroepithelium; teratomatous endoderm gives rise to alimentary and respiratory epithelium; and mesoderm becomes muscle and cartilage. Embryoid bodies with inverted germ layers are observed in enormous numbers in ascitic fluid resulting from intraperitoneal grafts of transplantable teratomas. The endoderm in these formations resembles that in 6-day-old mouse embryos. The endoderm of the early primary tumors is similar to alimentary epithelium in 9-day-old embryos. Apparently the environment, whether fluid or cellular, exerts an important influence on the configuration of endodermal cells. The arrangement of endodermal cells in embryoid bodies indicates that they have centrifugal migration tendencies, which may explain, tentatively, the inversion of the germ layers in mouse embryos. In most of the early teratomas there is direct continuity between the germinal epithelium and teratomatous elements. This suggests, but is not critical proof, that testicular teratomas originate within the tubules of the fetal mouse testis.
Asparaginase-Associated Lipid Abnormalities in Children With Acute Lymphoblastic Leukemia
Authors: Susan K. Parsons, Stephen X. Skapek, Ellis J. Neufeld, Caroline Kuhlman, Mary L. Young, Mia Donnelly, John D. Brunzell, James D. Otvos, Stephen E. Sallan, Nader Rifai
Journal: Blood (1997)
Varmus Returns to His Roots in Cancer Genetics
Authors: Bridget M. Kuehn
Journal: JAMA (2015)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Abstract 11821: HDL-Induced Cholesterol Efflux Capacity From Niacin Therapy in Diabetes is Haptoglobin Genotype-Dependent
Authors: Rabea Asleh, Dan Farbstein, Shany Blum, Moshe Vardi, Hadar Shalom, Sanatan Saraf, Kevin O`Brien, Santica Marcovina, Barbara H Roberts, David Herrington, Jennifer G Robinson, Andrew P Levy
Journal: Circulation (2014)

Objectives:  One possible explanation for the recent failure of HDL raising therapies such as niacin to reduce cardiovascular disease (CVD) may be that raising HDL is beneficial only in individuals with preserved HDL function. There exists two common alleles at the Haptoglobin (Hp) genetic locus, 1 and 2, with a 2-3 fold increased rate of CVD in individuals with diabetes mellitus (DM) and the Hp 2-2 genotype. We recently demonstrated that Hp 2-2 DM individuals have pro-inflammatory dysfunctional HDL. We therefore sought to test the hypothesis in AIM HIGH that benefit from niacin on HDL function would be Hp genotype-dependent.   Methods:  Stored serum samples from all 1140 DM participants in AIM HIGH were Hp typed. Cholesterol efflux capacity was evaluated at baseline and at one year of treatment in 70 Hp 1-1 and 70 Hp 2-2 DM individuals randomly selected in equal proportions from the niacin and placebo groups.   Results:  At baseline, efflux capacity of serum from Hp 1-1 was significantly greater than that from Hp 2-2 participants (11.1% vs. 9.6%, p=0.001). In the 4 treatment groups evaluated for efflux capacity (Hp 1-1 and Hp 2-2 ± niacin), a significant increase in efflux capacity at one year into the study was only found in the niacin treated Hp 1-1 group (14% increase in median efflux, p   Conclusions:  Benefit from niacin on cholesterol efflux capacity appears to be Hp genotype-dependent. A larger sample size is needed to determine if this translates into a meaningful change in clinical events.
Images from the mind: BCI image evolution based on rapid serial visual presentation of polygon primitives
Authors: Luís F. Seoane, Stephan Gabler, Benjamin Blankertz
Journal: Brain-Computer Interfaces (2015)

This paper provides a proof of concept for an EEG-based reconstruction of a visual image which is on a user's mind. Our approach is based on the rapid serial visual presentation (RSVP) of polygon primitives and brain-computer interface (BCI) technology. The presentation of polygons that contribute to building a target image (because they match the shape and/or color of the target) trigger attention-related EEG patterns. Accordingly, these target primitives can be determined using BCI classification of event-related potentials (ERPs). They are then accumulated in the display until a satisfactory reconstruction is reached. Selection steps have an average classification accuracy of 75%. Twenty-five percent of the images could be reconstructed completely, while more than 65% of the available visual details could be captured on average. Most of the misclassifications were not misinterpretations of the BCI concerning users' intent; rather, users tried to select polygons that were different than what was intended by the experimenters. Open problems and alternatives to develop a practical BCI-based image reconstruction application are discussed.
Abstract 19749: Racial Differences in Outcomes With Dabigatran in Elderly Atrial Fibrillation Patients
Authors: Rajesh Kabra, Mary Vaughan-Sarrazin
Journal: Circulation (2014)

Introduction: Dabigatran was shown to be superior to warfarin in stroke prevention in patients with non-valvular atrial fibrillation (AF) in the RE-LY clinical trial. However, the majority of patients were white, and it is unclear whether its beneficial results can be extrapolated to black patients. Hypothesis: To study the outcomes of dabigatran in comparison to warfarin, in white and black patients with AF. Methods: Patients with newly diagnosed AF from November 2010 to December 2011 were identified using the Medicare Beneficiary Summary Chronic Condition flags. Inclusion criteria was age 66 or older, black or white race, enrolled in Medicare Part D, and received warfarin or dabigatran within 90 days of AF diagnosis. Patients who were on warfarin prior to the AF diagnosis were excluded. The primary outcome of death and secondary outcomes of stroke, gastrointestinal bleeding and intracranial hemorrhage were investigated in analyses that incorporated propensity matching by anticoagulant type within race. ...
Ligation of CD31 (PECAM-1) on Endothelial Cells Increases Adhesive Function of vβ3 Integrin and Enhances β1 Integrin-Mediated Adhesion of Eosinophils to Endothelial Cells
Authors: Ryuichi Chiba, Noriaki Nakagawa, Kazuhiro Kurasawa, Yoshiya Tanaka, Yasushi Saito, Itsuo Iwamoto
Journal: Blood (1999)
Does the internet harm health?
Authors: R. Kiley
Journal: BMJ (2002)

Editor—I would take issue with the statement that there is almost no evidence to support the claim that the internet harms health.1 A search of Medline, for example, identifies a report in the Annals of Internal Medicine (www.annalsw.org/issues/v133n11/nts/200012050-00006.html) that describes the case of a patient who died of kidney and liver failure after using hydrazine sulphate (as recommended by the Kathy Keeton website, www.kathykeeton-cancer.com) as an alternative treatment for cancer.2

On another occasion a nurse in the United States was charged with manslaughter after giving MICON—a non-toxic treatment given over 24 hours (www.edensinstitute.com/micom.html)—to a patient with cancer (see www.ncahf.org/digest/01-18.html).

In addition to these examples there are other cases when people find a “cure” on the web and use this, possibly at the expense of conventional treatment. A newspaper article in England (www.thisiswiltshire.co.uk/wiltshire/archive/2000/11/23/devizes_news_county2ZM.html) told of a local patient with cancer who raised money to go to a private clinic in Mexico to receive treatment with Laetrile (laevo-mandelonitrile-beta-glucuronoside). The article quoted local (Mexican) doctors as being “confident” that this would cure the cancer. In contrast, the National Cancer Institute reports that “Laetrile has shown little anticancer activity in animal studies and no anticancer activity in human clinical trials” (www.cancernet.nci.nih.gov/cam/laetrile.htm).

Medical misinformation is a problem on the internet. The danger is that vulnerable people will adopt these unproved treatments at the expense of proved conventional ones.
Genetic defect in human X-linked agammaglobulinemia impedes a maturational evolution of pro-B cells into a later stage of pre-B cells in the B-cell differentiation pathway.
Authors: Keiko Nomura, Hirokazu Kanegane, Hajime Karasuyama, Satoshi Tsukada, Kazunaga Agematsu, Gyokei Murakami, Satoru Sakazume, Masahiro Sako, Rieko Tanaka, Yoshinori Kuniya, Takuya Komeno, Shigehiko Ishihara, Keizo Hayashi, Tadamitsu Kishimoto, Toshio Miyawaki
Journal: Blood (2000)
THE GROWING IMPORTANCE OF CARDIAC NEUROSIS
Authors: Paul D. White, R. Earle Glendy
Journal: Annals of Internal Medicine (1937)

Article1 May 1937THE GROWING IMPORTANCE OF CARDIAC NEUROSISPAUL D. WHITE, M.D., F.A.C.P., R. EARLE GLENDY, M.D.PAUL D. WHITE, M.D., F.A.C.P.Search for more papers by this author, R. EARLE GLENDY, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-10-11-1624 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptI. IntroductionII. Case histories of patients with cardiac neurosis, with and without heart diseaseA. Neurosis predominatingCase 1. Neurosis Induced Largely by Neurocirculatory Asthenia. Normal Heart.Case 2. Neurosis Initiated by Paroxysmal Tachycardia. Normal Heart. Case 3. Neurosis Induced by Sudden Knowledge of Compensable Heart Disease While in Army. Rheumatic Valvular Disease.Case 4. Neurosis Following Coronary Thrombosis.B. Heart disease predominatingCase 5. Severe Coronary Heart Disease Masked by Psychoneurosis and Morphinism.III. Summary and conclusionsI. INTRODUCTIONThe more heart disease there is, and especially the more widespread the publicity about it, the more important becomes...Reference1. GLENDYWHITE REPD: The recognition and treatment of cardiac neurosis, Med. Clin. N. Am., 1937, Boston number, p. 449. CrossrefGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Boston, Massachusetts*Received for publication March 3, 1937.From the Cardiac Clinic and Laboratory of the Massachusetts General Hospital. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byUnmasking the true face of postural orthostatic tachycardia syndromeZinkThe Importance of Recognizing Post-Infarctional Shoulder-Hand Syndrome 1 May 1937Volume 10, Issue 11Page: 1624-1635KeywordsCardiovascular therapyCoronary heart diseaseHeartHeart diseasesHospitalsResearch laboratoriesTachycardiaThrombosisValvular diseases Issue Published: 1 May 1937 PDF downloadLoading ...
645. AAV Mediated Human Insulin Gene Expression in Liver of Diabetic Rats
Authors: Seonock Woo, Hyejoo Kim
Journal: Molecular Therapy (2004)

Top of pageAbstract
A lot of therapeutic approaches to cure diabetes have been tried but still remains unsatisfied. This research purposed to express furin-cleavage human proinsulin in liver of diabetic animal using adeno-associated virus (AAV) and to provide constant insulin level for basal requirement in diabetes. Adeno-associated virus expressing furin-cleavage human proinsulin (AAV-FhPI) under CMV promoter was administered into portal vein of streptozotocin (STZ)-induced diabetic rats. This resulted in the decrease of blood glucose levels and normalized glucose tolerance. Treated rats exhibited the normalized blood glucose levels in fasting state over 3 months. The ability of glucose clearance approximated to non-diabetic control and the hemoglobin A1c concentrations were decreased in AAV-FhPI treated rats. Immunohistochemical studies of pancreas in AAV-FhPI treated rats revealed the pancreatic -cells were mostly destroyed while transduced hepatocytes produced human insulin. In conclusion, viral vector-mediated furin-cleavage proinsulin gene expression using the constitutive promoter is feasible gene therapy to supply basal insulin, lessening the frequency of insulin injection. And portal vein injection is suitable to enhance the exogenous gene delivery into liver.
The carnage wrought by major economic change: ecological study of traffic related mortality and the reunification of Germany Commentary: Road deaths in European countries
Authors: F. K Winston, C. Rineer, R. Menon, S. P Baker, M. McCarthy
Journal: BMJ (1999)

To document the effects of sudden economic change on death rates for occupants of cars in the former German Democratic Republic (East Germany).Ecological time series study of East Germany in comparison with the former Federal Republic of Germany (West Germany) before and after reunification in 1990.East and West Germany from 1985 to 1996.Populations of East and West Germany between 1985 and 1996.Death rates for occupants of cars.After the reunification of Germany, East Germany experienced a sudden, temporary affluence and a concomitant fourfold increase in death rates for car occupants between 1989 and 1991. Although death rates increased in all age groups, young adults (aged 18-24) were most affected. The death rate per 100 000 population for those aged 18-20 years increased 11-fold between 1989 and 1991; for those aged 21-24 years the increase was eightfold.A tragic consequence of the reunification of Germany was a dramatic increase in the death rate for car occupants. Sudden economic change and availability of cars resulted in both a rise in vehicle ownership and an increase in the number of inexperienced drivers on roads that were ill prepared for the increased traffic. The lesson learnt from Germany is that during times of economic change and modernisation, measures to prevent the predictable injury deaths that will result need to be considered.
Champs de Mars: The Red Tower
Authors: M. Therese Southgate
Journal: JAMA (2000)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Abstract 92: Generating new syngeneic models for oral squamous cell carcinoma metastasis study
Authors: Zonggao Shi, Jeff Johnson, Yueying Liu, Sharon Stack
Journal: Cancer Research (2014)

Abstract Cancer metastasis is a complex problem that presents clinical challenges and is the cause of most cancer-related deaths. Mechanistic studies on metastasis hold promise for finding better approaches to control cancer mortality. Oral cavity cancer brings over 200,000 deaths annually and is one of the top eight most frequently diagnosed cancers worldwide. However there is a lack of appropriate experimental models to address oral cancer metastasis. An ideal experimental system should recapitulate the complete process of cancer metastasis in vivo while maintaining molecular-level manipulability. Our current efforts are directed at development of a series of murine oral squamous cell carcinoma (OSCC) cell lines that will be amenable for syngeneic transplantation studies in immuno-competent mice. The cell lines were created from C57BL/6J mice, a strain frequently used in targeted gene manipulation. This strategy ensures that the cells also have utility in orthotopic xenograft cancer models using currently available knockout mice made with a syngeneic background. As abundant knockout mice are available on the C57BL/6J background, our new syngeneic cancer cell lines will greatly facilitate studies on the interrelationship between host and tumor during the process of metastasis. Cell lines were generated from primary murine tongue epithelial cells by hTERT induced immortalization and oncogene induced transformation. They were screened for tumorigenicity and metastasis in both immunocompetent and immunocompromised mice. Properties of in vitro and vivo growth, morphology and cytogenetics were characterized. As proof of concept, one type of gene knockout mouse was used to test transplantation of such new cellular models in vivo to observe the impact of gene loss in the host on the growth and metastasis of tumors. The completion of this project will establish solid and currently unavailable tools for the oral cancer metastasis research community. Citation Format: Zonggao Shi, Jeff Johnson, Yueying Liu, Sharon Stack. Generating new syngeneic models for oral squamous cell carcinoma metastasis study. [abstract]. In: Proceedings of the 105th Annual Meeting of the American Association for Cancer Research; 2014 Apr 5-9; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2014;74(19 Suppl):Abstract nr 92. doi:10.1158/1538-7445.AM2014-92
Blood flow–metabolism imaging with positron emission tomography in patients with diabetes mellitus for the assessment of reversible left ventricular contractile dysfunction 11The Laboratory of Structural Biology and Molecular Medicine is operated for the U.S. Department of Energy by the University of California under Contract #DE-FC03-87ER60615.
Authors: Heiko Schöder, Roxana Campisi, Tohru Ohtake, Carl K Hoh, Dae H Moon, Johannes Czernin, Heinrich R Schelbert
Journal: Journal of the American College of Cardiology (1999)
The ethics of intimate examinations---teaching tomorrow's doctors * Commentary: Respecting the patient's integrity is the key * Commentary: Teaching pelvic examination---putting the patient first
Authors: Y. Coldicott
Journal: BMJ (2003)

<i>The teaching of vaginal and rectal examinations poses ethical problems for students and educators, and guidelines exist to protect patients from unethical practice. Yvette Coldicott and colleagues report an exploratory survey, whose findings suggest that best practice is not always followed and that in many cases consent has not been given for procedures</i>
Who is being screened for melanoma/skin cancer?
Authors: Howard K. Koh, Alan C. Geller, Donald R. Miller, Anthony Caruso, Irene Gage, Robert A. Lew
Journal: Journal of the American Academy of Dermatology (1991)

We conducted a survey of persons who voluntarily attended melanoma/skin cancer screenings in Massachusetts in 1987. Of 1219 persons asked to fill out a questionnaire, 1116 (92%) completed it. Our study demonstrates that persons attending the melanoma/skin cancer screening program were, for the most part, at risk for the disease and appropriately selected themselves to be screened. Most were women, well educated (with college or advanced degrees), and white. More than 86% had at least one risk factor for melanoma/skin cancer whereas 78% had at least two risk factors. Future studies are necessary to determine whether our experience can be verified. Additional efforts should try to attract those who are at risk but perhaps are less willing to attend screening programs—men and those of lower socioeconomic status. These efforts can help target screening to those at highest risk and maximize the yield of these public health efforts. We conducted a survey of persons who voluntarily attended melanoma/skin cancer screenings in Massachusetts in 1987. Of 1219 persons asked to fill out a questionnaire, 1116 (92%) completed it. Our study demonstrates that persons attending the melanoma/skin cancer screening program were, for the most part, at risk for the disease and appropriately selected themselves to be screened. Most were women, well educated (with college or advanced degrees), and white. More than 86% had at least one risk factor for melanoma/skin cancer whereas 78% had at least two risk factors. Future studies are necessary to determine whether our experience can be verified. Additional efforts should try to attract those who are at risk but perhaps are less willing to attend screening programs—men and those of lower socioeconomic status. These efforts can help target screening to those at highest risk and maximize the yield of these public health efforts.