KLINEFELTER'S SYNDROME: A REPORT OF A CASE WITH SOME UNUSUAL FEATURES
Authors: P C WALKER, P R McCURDY
Journal: Annals of Internal Medicine (1955)

Case Reports1 July 1955KLINEFELTER'S SYNDROME: A REPORT OF A CASE WITH SOME UNUSUAL FEATURESPHYLLIS C. WALKER, M.D., PAUL R. MCCURDY, M.D.PHYLLIS C. WALKER, M.D.Search for more papers by this author, PAUL R. MCCURDY, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-43-1-206 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptHypogonadism in the male has long been recognized. However, it is only in recent years, with the use of hormonal assays and testicular biopsy, that a more rational approach to the etiology and treatment of this entity has been utilized. Briefly, hypogonadism has been classified into prepuberal and postpuberal groups, and division has been further aided by determination of the pituitary gonadotropic hormones in the urine. Thus, a hypogonadotropic or secondary testicular failure group and a hypergonadotropic or primary testicular failure group are elicited. Testicular morphology correlates with and aids in this differentiation.1, 2Klinefelter, Reifenstein and Albright were among...Bibliography1. Nelson WO: Interpretation of the testicular biopsy, J. A. M. A. 151: 449, 1953. MedlineGoogle Scholar2. SniffenHowardSimmons RCRPFA: The testes, Arch. Path. 51: 293, 1951. Google Scholar3. KlinefelterReifensteinAlbright HFHCF: Syndrome characterized by gynecomastia, aspermatogenesis without a-Leydigism, and increased excretion of FSH, J. Clin. Endocrinol. 2: 615, 1942. CrossrefGoogle Scholar4. HellerNelson CGWO: Hyalinization of the seminiferous tubules associated with normal or failing Leydig-cell function. Discussion of relationship to eunuchoidism, gynecomastia, elevated gonadotropins, depressed 17-ketosteroids and estrogens, J. Clin. Endocrinol. 5: 1, 1945. CrossrefGoogle Scholar5. HellerNelson CGWO: op. cit., pg. 4. Google Scholar6. Kober S: Colorimetric estimation of estrogenic hormones; esterone, Biochem. J. 32: 357, 1938. CrossrefMedlineGoogle Scholar7. Pincus G: The analysis of human urines for steroid substances, J. Clin. Endocrinol. 5: 291, 1945. CrossrefGoogle Scholar8. VenningPatteeMcCallBrowne EECJFJS: The effect of cortisone on the excretion of 17-ketosteroids in adrenal tumors, J. Clin. Endocrinol. 12: 1409, 1952. CrossrefGoogle Scholar9. MigeonGardner CJLI: Urinary estrogens (measured fluorometrically and biologically) in hyperadrenocorticism: influence of cortisone, compound F, compound B, and ACTH, J. Clin. Endocrinol. 12: 1513, 1952. CrossrefGoogle Scholar10. JailerGoldWallace JWJJEZ: Evaluation of the "cortisone test" as a diagnostic aid in differentiating adrenal hyperplasia from adrenal neoplasia, Am. J. Med. 16: 340, 1954. CrossrefMedlineGoogle Scholar11. Werner CA: Mumps orchitis and testicular atrophy. I. Occurrence, Ann. Int. Med. 32: 1066, 1950. LinkGoogle Scholar12. Gall EA: The histopathology of acute mumps orchitis, Am. J. Path. 23: 637, 1947. MedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: *Received for publication July 20, 1954.From the Medical Service of the Veterans Administration Hospital, Seattle, Washington, and the Department of Medicine of the University of Washington School of Medicine. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 July 1955Volume 43, Issue 1Page: 206-212KeywordsEtiologyExcretionHormonesHospital medicineHypogonadismMedical servicesOrchitisProlactinTestesUrine ePublished: 1 December 2008 Issue Published: 1 July 1955 PDF downloadLoading ...