THE TREATMENT OF LOBAR PNEUMONIA WITH SULFAPYRIDINE AND SODIUM SULFAPYRIDINE, WITH OBSERVATIONS UPON EFFECTIVE BLOOD LEVELS
Authors: Theodore J. Abernethy, Harry F. Dowling, Clarence R. Hartman
Journal: Annals of Internal Medicine (1940)

Article1 January 1940THE TREATMENT OF LOBAR PNEUMONIA WITH SULFAPYRIDINE AND SODIUM SULFAPYRIDINE, WITH OBSERVATIONS UPON EFFECTIVE BLOOD LEVELSTHEODORE J. ABERNETHY, M.D., HARRY F. DOWLING, M.D., CLARENCE R. HARTMAN, M.D.THEODORE J. ABERNETHY, M.D.Search for more papers by this author, HARRY F. DOWLING, M.D.Search for more papers by this author, CLARENCE R. HARTMAN, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-13-7-1121 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptSince the demonstration by Whitby1of the specific action of sulfapyridine against the pneumococcus, the value of this new chemotherapeutic agent in the treatment of lobar pneumonia has been the subject of extensive clinical investigation. The report of Evans and Gaisford,2describing the results of treatment of 100 patients ill with lobar pneumonia, was so impressive that a stimulus was given for a wide-spread trial of the drug in this country. Subsequent publications,3-7already voluminous, not only have confirmed the observations of Evans and Gaisford, but have established a definite place for sulfapyridine in the treatment of pneumococcus lobar pneumonia....Bibliography1. WHITBY LE: Chemotherapy of pneumococcal and other infections with M. and B. 693, Lancet, 1938, i, 1210. CrossrefGoogle Scholar2. EVANSGAISFORD GMWF: Treatment of pneumonia with 2-(p-aminobenzenesulphonamido) pyridine, Lancet, 1938, ii, 14. CrossrefGoogle Scholar3. AGRANATDREOSTIORDMAN ALAOD: Treatment of pneumonia with 2-(p-aminobenzenesulphonamido) pyridine, Lancet, 1939, i, 309-317, 380-384. CrossrefGoogle Scholar4. FLIPPINPEPPER HFDS: The use of 2-(p-aminobenzenesulphonamido) pyridine in the treatment of pneumonia, Am. Jr. Med. Sci., 1938, cxcvi, 509. CrossrefGoogle Scholar5. FLIPPINLOCKWOODPEPPERSCHWARTZ HFJSDSL: The treatment of pneumococcic pneumonia with sulfapyridine, Jr. Am. Med. Assoc., 1939, cxii, 529. CrossrefGoogle Scholar6. PEPPERFLIPPINSCHWARTZLOCKWOOD DSHFLJS: The results of sulfapyridine therapy in 400 cases of typed pneumococcic pneumonia, Am. Jr. Med. Sci., 1939, cxcviii, 22. CrossrefGoogle Scholar7. FINLANDSPRINGLOWELLBROWN MWCFCJW: Specific serotherapy and chemotherapy of the pneumococcus pneumonias, ANN. INT. MED., 1939, xii, 1816. Google Scholar8. LONGFEINSTONE PHWH: Observations upon the absorption and excretion of sulfapyridine (2 sulfanilyl aminopyridine), Proc. Soc. Exper. Biol. and Med., 1938, xxxix, 486. CrossrefGoogle Scholar9. STOKINGER HE: Absorption, acetylation and excretion of 2 sulfanilamidopyridine, Proc. Soc. Exper. Biol. and Med., 1939, xl, 61. CrossrefGoogle Scholar10. LONGBLISS PHEA: The clinical and experimental use of sulfanilamide, sulfapyridine and allied compounds, 1939, The Macmillan Company, New York, 230-231. Google Scholar11. WHITBY LE: Chemotherapy of bacterial infections (Bradshaw Lecture), Lancet, 1938, ii, 1095. CrossrefGoogle Scholar12. BARNETTHARTMANNPERLEYRUHOFF HLAFAMMB: The treatment of pneumococcic infections in infants and children with sulfapyridine, Jr. Am. Med. Assoc., 1939, cxii, 518. CrossrefGoogle Scholar13. MARSHALLLONG EKPH: The intravenous use of sodium sulfapyridine, Jr. Am. Med. Assoc., 1939, cxii, 1671. CrossrefGoogle Scholar14. MARSHALL EK: Determination of sulfanilamide in blood and urine, Jr. Biol. Chem., 1937, cxxii, 263. CrossrefGoogle Scholar15. MARSHALLLITCHFIELD EKJT: Determination of sulfanilamide, Science, 1938, lxxxviii, 85. CrossrefGoogle Scholar16. DOWLINGABERNETHY HFTJ: The incidence of pneumococcus types and the reliability of the Neufeld typing method, ANN. INT. MED., 1939, xiii, 115. Google Scholar17. DOWLINGABERNETHY HFTJ: Observations on the use of the sodium salt of sulfapyridine: a preliminary report, Med. Ann. District of Columbia, 1939, viii, 127. Google Scholar18. ABERNETHYDOWLING TJHF: The pneumonia control program, District of Columbia. Report of results obtained in treatment of Type I cases, Med. Ann. District of Columbia, 1938, vii, 384. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Washington, D. C.*Received for publication September 14, 1939.From the Health Department of the District of Columbia and the Department of Medicine, George Washington University.The authors gratefully acknowledge the coöperation of Dr. George C. Ruhland, Health Officer, Dr. J. G. Cumming, Director, Bureau of Preventable Diseases, and Dr. J. E. Noble, Director of Laboratories, District of Columbia Health Department. Valuable technical assistance was given by Miss Emily Godfrey, Miss Margaret McMahon and Mr. Norman E. Yongue.We are indebted to Merck & Company, Inc., and to the Lederle Laboratories, Inc., for the sulfapyridine and sodium sulfapyridine used in this study. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byDie PneumonienPNEUMONIA TREATED WITH SULPHA- PYRIDINE AND SULPHATHIAZOLE CONCENTRATION OF THE DRUGS IN THE BLOOD 1 January 1940Volume 13, Issue 7Page: 1121-1137KeywordsBloodChemotherapeutic agentsDrugsPatientsPneumococcusPneumoniaSodium ePublished: 1 December 2008 Issue Published: 1 January 1940 PDF downloadLoading ...