tbuckley/cabot-search huggingface dataset:
Prophylactic antibiotics for the prevention of cellulitis (erysipelas) of the leg. A commentary
Authors: O. Chosidow, L. Le Cleach
Journal: British Journal of Dermatology (2011)

Journal Article Prophylactic antibiotics for the prevention of cellulitis (erysipelas) of the leg. A commentary Get access O. Chosidow, O. Chosidow Department of Dermatology, Hôpital Henri Mondor, and UPEC Université Paris‐Est Val de Marne, Créteil, France E‐mail: olivier.chosidow@hmn.aphp.fr Search for other works by this author on: Oxford Academic Google Scholar L. Le Cleach L. Le Cleach Department of Dermatology, Hôpital Henri Mondor, and UPEC Université Paris‐Est Val de Marne, Créteil, France E‐mail: olivier.chosidow@hmn.aphp.fr Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 166, Issue 1, 1 January 2012, Page 6, https://doi.org/10.1111/j.1365-2133.2011.10740.x Published: 01 January 2012
974. Adeno-Associated Viral (AAV)-Mediated Gene Transfer of Soluble Vascular Endothelial Growth Factor Receptor 3 (sVEGFR3) Inhibits Development of Lymph Node Metastases
Authors: Jian-Min Lin, Alshad S. Lalani, Thomas Harding, Weiwei Wu, Bo Luan, Satya Yendluri, Melinda J. VanRoey, Yulong He, Kari Alitalo, Karin Jooss
Journal: Molecular Therapy (2004)
Comparison of standards for assessing patients' capacities to make treatment decisions
Authors: T Grisso, P S Appelbaum
Journal: American Journal of Psychiatry (1995)

This study investigated the proportion of psychiatric and medical patients who are impaired in their decision-making abilities in relation to each of several major legal standards for determining competence to consent to treatment.The subjects were hospitalized patients with diagnoses of schizophrenia (N = 75), major depression (N = 92), and ischemic heart disease (N = 82) and equal numbers of community comparison subjects matched on age, race, gender, education, and occupation. Three instruments measuring abilities related to the legal standards for competence were administered to each group. Impaired functioning was defined as scores two standard deviations below the means for all subjects combined or lower.Although similar percentages of subjects with impaired performance were found for each of the measures, different groups of patients were identified as impaired depending on the measure used. The proportion of patients identified as impaired increased when compound standards were used, i.e., when impairment was defined as poor performance on any of two or three measures. Despite previous suggestions that the legal standards might form a hierarchy of rigorousness, the data did not support this hypothesis.Choice of standards for determining competence, including compound standards, will affect the identity and proportion of patients classified as impaired. Clinicians should be aware of applicable standards in their jurisdictions. Use of compound standards requires independent evaluation of performance on abilities related to each relevant standard, because standards do not appear to be hierarchical. Policies relating to the characterization of persons as incompetent must be fashioned with caution.
The value of flow cytometric analysis of platelet glycoprotein expression of CD34+ cells measured under conditions that prevent P- selectin-mediated binding of platelets
Authors: MW Dercksen, IS Weimar, DJ Richel, J Breton-Gorius, W Vainchenker, CM Slaper- Cortenbach, HM Pinedo, AE von dem Borne, WR Gerritsen, CE van der Schoot
Journal: Blood (1995)
308. A New Model to Functionally Measure Fusion Events in the Liver after Bone-Marrow Transplantation over Time
Authors: Konrad L. Streetz, Denison D. Jenkins, Michael T. Longaker, Karl G. Sylvester, Mark A. Kay
Journal: Molecular Therapy (2004)

Cell fusion of donor derived bone-marrow cells (BM) with liver cells has been studied extensively in the recent past. As fusion is an extremly rare event in most models detailed histological analysis had to be undertaken for any quantification so far. Here we present a model that allows quantification of hepatocyte specific functions of donor derived cells at a functional level over time.
The Hedgehog signalling pathway in bone formation
Authors: Jing Yang, Philipp Andre, Ling Ye, Ying-Zi Yang
Journal: International Journal of Oral Science (2015)

The Hedgehog (Hh) signalling pathway plays many important roles in development, homeostasis and tumorigenesis. The critical function of Hh signalling in bone formation has been identified in the past two decades. Here, we review the evolutionarily conserved Hh signalling mechanisms with an emphasis on the functions of the Hh signalling pathway in bone development, homeostasis and diseases. In the early stages of embryonic limb development, Sonic Hedgehog (Shh) acts as a major morphogen in patterning the limb buds. Indian Hedgehog (Ihh) has an essential function in endochondral ossification and induces osteoblast differentiation in the perichondrium. Hh signalling is also involved intramembrane ossification. Interactions between Hh and Wnt signalling regulate cartilage development, endochondral bone formation and synovial joint formation. Hh also plays an important role in bone homeostasis, and reducing Hh signalling protects against age-related bone loss. Disruption of Hh signalling regulation leads to multiple bone diseases, such as progressive osseous heteroplasia. Therefore, understanding the signalling mechanisms and functions of Hh signalling in bone development, homeostasis and diseases will provide important insights into bone disease prevention, diagnoses and therapeutics.
Abstract 3641: 25-OH Vitamin D Deficiency and the Risk of All-Cause Mortality in the General Population: Results from the Third National Health and Nutrition Examination Survey Linked Mortality Data
Authors: Erin D Michos, Michal L Melamed, Wendy Post, Brad C Astor
Journal: Circulation (2007)

Background: Vitamin D deficiency is common. In patients on dialysis, activated vitamin D therapy is associated with reduced mortality. However, whether low 25-hydroxyvitamin D (25-OH D) levels are ...
Evaluation of an In Vitro Assay System for Carcinogens Based on Prior Infection of Rodent Cells With Nontransforming RNA Tumor Virus2
Authors: Johng S. Rhim, Dai K. Park, Elizabeth K. Weisburger, John H. Weisburger
Journal: JNCI Journal of the National Cancer Institute (1974)

Different types of chemical carcinogens (polycyclic hydrocarbons, azo dyes, aromatic amines, nitrosamines, and urethans) and some noncarcinogenic analogs were tested in vitro for their transforming activity in the AKR leukemia virus-infected NIH Swiss mouse-embryo cell system. Their transforming activities in vitro were compared to their known in vivo carcinogenic activities; in general, these activities were found to be the same in vitro and in vivo.
Abstract 1649: Extent and location of tumor infiltrating lymphocytes in colon cancer predicts outcome to adjuvant active specific immunotherapy
Authors: Erik Hooijberg, Annelies W. Turksma, Marc Shamier, Kevin Lam, Veerle MH Coupe, Vincent A. de Weger, Jeroen AM Belien, Alfons J. van den Eertwegh, Gerrit A. Meijer, Chris JLM Meijer
Journal: Cancer Research (2014)

Abstract Purpose: We investigated the prognostic and predictive value of tumor infiltrating lymphocytes (TIL) in colorectal cancer in a cohort of patients who previously took part in a trial on adjuvant Active Specific Immunotherapy (ASI). Experimental Design: We determined the numbers of CD3+ and CD8+ cells in archival tumor samples of 110 colorectal cancer patients as total infiltrating TIL, intraepithelial TIL and stromal TIL. Survival curves were used to determine the prognostic and predictive value of TIL. Results: Patients with microsatellite instable (MSI) tumors had higher numbers of intraepithelial CD3+ and CD8+ TIL compared to patients with microsatellite stable (MSS) tumors. Patients with MSI tumors had a good prognosis. Patients with MSS cancers with high intraepithelial or stromal TIL numbers had a better prognosis compared to those with low TIL numbers. Significant survival benefits were found for the disease specific survival (DSS) and recurrence free interval (RFI) for patients with high infiltrates of stromal CD3+ or intraepithelial CD8+ cells. Additionally high numbers of total CD8+ and high stromal CD8+ cells gave a significant difference in RFI compared to low TIL numbers. The numbers of TIL found in MSS tumors also have predictive value with respect to response to adjuvant ASI treatment. Compared to controls significance was reached in ASI treated patients with high total CD3, high stromal CD3 or high stromal CD8 numbers in DSS as well as RFI. Conclusion: ASI therapy is effective in patients with MSS colorectal tumors harboring high numbers of preexisting stromal CD3 or CD8 positive TIL. Citation Format: Erik Hooijberg, Annelies W. Turksma, Marc Shamier, Kevin Lam, Veerle MH Coupe, Vincent A. de Weger, Jeroen AM Belien, Alfons J. van den Eertwegh, Gerrit A. Meijer, Chris JLM Meijer. Extent and location of tumor infiltrating lymphocytes in colon cancer predicts outcome to adjuvant active specific immunotherapy. [abstract]. In: Proceedings of the 105th Annual Meeting of the American Association for Cancer Research; 2014 Apr 5-9; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2014;74(19 Suppl):Abstract nr 1649. doi:10.1158/1538-7445.AM2014-1649
Abstract 655: Effect of antibody mixtures on HER-family heterodimerization
Authors: Sofie Ellebæk, Thomas Bouquin, Michael V. Grandal, Michael Kragh, Thomas T. Poulsen
Journal: Cancer Research (2014)

Abstract Members of the human epidermal growth factor receptor (HER)-family, i.e. EGFR, HER2, and HER3, are key oncogenic drivers in numerous cancer forms. Monoclonal antibody therapeutics targeting EGFR and HER2 have been clinically approved and HER3-targeting antibodies are in clinical development. However, resistance to single HER treatment occurs due to mechanisms such as incomplete target elimination and a switch of receptor dependency in the resistant cancer cell population. Another potential escape mechanism for the cancer cells to become resistant and maintain oncogenic signaling is receptor heterodimerization. It is therefore relevant to investigate how heterodimers can be downregulated when targeted with antibodies against a single or multiple HER targets. It is well established that mixtures of two or more antibodies against a single HER family receptor induce superior and rapid receptor downregulation and elimination compared with monoclonal antibodies. However, the effect of antibody mixtures on HER heterodimer distribution has not been investigated. At Symphogen, we have generated Pan-HER, a combination of two EGFR-, two HER2-, and two HER3-targeting monoclonal antibodies with non-overlapping epitopes in a single drug compound. Detection and quantification of the HER family member distribution in selected cancer cell lines, as well as proliferation assays with combinations of the antibody components comprising Pan-HER have been performed to investigate the effects of 2-, 4- and 6-mixtures of antibodies. Results from studies focusing on characterization of receptor levels, surface expression and heterodimer formation in Pan-HER responsive cancer cell lines will be presented, as well as the effect of Pan-HER on receptor heterodimer distribution, investigated by Co-IP and Duolink Proximity Ligation Assay technology. Our results show that mixtures of antibodies against more than one HER family member potently downregulate the HER family receptor levels and significantly alter the HER family heterodimerization pattern upon short- and long-term exposure to HER-targeting antibodies. Citation Format: Sofie Ellebæk, Thomas Bouquin, Michael V. Grandal, Michael Kragh, Thomas T. Poulsen. Effect of antibody mixtures on HER-family heterodimerization. [abstract]. In: Proceedings of the 105th Annual Meeting of the American Association for Cancer Research; 2014 Apr 5-9; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2014;74(19 Suppl):Abstract nr 655. doi:10.1158/1538-7445.AM2014-655
Difference of patient background with pneumonia between monotherapy and combination
Authors: Masataka Shibasaki, Mitsunori Nishikawa, Yuichi Kitagawa, Kazuyoshi Senda, Kazumitsu Nakashima, Fumihiro Mizokami
Journal: European Respiratory Journal (2011)

Background:  The current guidelines recommend combination therapy of antibiotics empirically for pneumonia patients with risks of PDR pathogens. However, this recommendation remains controversial. [Aims and objectives] To elucidate factors which may lead physicians to select combination therapy of antibiotics for pneumonia.   Materials:  Pneumonia patients who were admitted to National Center for Geriatrics and Gerontology Hospital from April 2008 to December 2009, and treated with carbapenem (A group, n=70) or combination of carbapenem+aminoglycosides (B group, n=68).   Methods:  Information on age, gender, weight, risk factors of PDR pathogens, pneumonia type (CAP/HCAP/HAP), Barthel index, clinical response, duration of therapy and 30-day mortality were obtained from chart review. We compared the aforementioned factors between two groups using multiple logistic regression analysis.   Results:  There were significant differences about the aforementioned factors except age between A and B group in univariate analysis. However, in multivariate logistic regression analysis, only Barthel index was significantly different between both groups (81.8±29.2 in A group vs. 59.1±40.3 in B group,  P  P =0.067). Duration of antibiotics therapy was significantly shorter in A group compared with B group (7.3±4.7 vs. 19.3±8.2 days, respectively,  P    Conclusion:  Barthel index was the independent factor which affected physicians to select combination therapy of antibiotics.
Principles and Practice of Nephrology.
Authors: Harry R. Jacobson, Gary E. Striker, Saulo Klahr
Journal: Annals of Internal Medicine (1991)

Fluid, electrolyte and acid-base disorders divalent ion metabolism and its regulation evaluation of renal function in diagnostic tests in nephrology glomerular diseases interstitial diseases cystic diseases, congenital disorders and genetic disorders obstruction of the urinary tract diabetes hypertension nephrotoxic injury renal disease in pregnancy infections acute renal failure chronic renal failure and the syndrome of uremia nutrition in renal disease principles and techniques for dialysis, plasmapheresis and haemoperfusion transplantation drugs in renal disease strategies for the prevention of renal failure.
Abstract 11740: Fetal and Neonatal Markers of Neurodevelopmental Outcome in Congenital Heart Disease
Authors: Ismee A Williams, Howard Andrews, Michael M Myers, William Fifer
Journal: Circulation (2014)

Objectives: Children with congenital heart disease (CHD) are at risk for abnormal neurodevelopment (ND). We evaluated associations between fetal Doppler and biometry measures, neonatal electroencephalogram (EEG) and 18-month ND. Methods: Fetuses with hypoplastic left heart syndrome (HLHS), transposition of the great arteries (TGA), and tetralogy of Fallot (TOF) had middle cerebral (MCA) and umbilical artery (UA) Doppler velocities, as well as biometry such as head (HC) and abdominal circumference (AC), prospectively recorded at 20-25 (F1), 26-32 (F2), and 33-39 (F3) wks gestational age (GA). Pulsatility indices (PI) with GA-derived z-scores and cerebral-to-placental resistance (CPR) ratios were calculated. Neonatal high-density EEG was preformed preoperatively and the Bayley Scales of Infant Development-III were assessed at 18-months. Factor analysis was used to reduce the number of EEG predictors used in regression analysis. Results: Among 56 CHD fetuses (N=19 HLHS, N=16 TGA, N=21 TOF) who underwent preoperative EEG, ND scores are available for 33 to date. Cardiac subtype was highly associated with EEG and was considered in all models. Cognition scores were predicted by CPR&lt; 1 ever (B=-15.7, P=0.002) and HC/AC at F2 (B=-130, P=0.013, R 2 =0.42). Language scores were predicted by UA PI z-score at F1 (B=-9.6, P=0.005, R 2 =0.27). Motor scores were predicted by UA PI z-score at F1 (B=-3.9, P=0.085), HLHS (B=-15, P&lt;0.001), EFW%ile (B=0.374, P=0.007), and delta band right parietal and right temporal log power in active sleep (B=3.9, P=0.045, R 2 =0.61). Conclusion: Lower umbilical artery pulsatility at 20-25 wks GA was associated with higher 18-month Language and Motor scores. A diagnosis of HLHS predicted poorer Motor scores. Increased EEG power in the parietal and temporal region of the right brain predicted higher Motor scores. A larger abdomen relative to head at 26-32 wks was associated with improved cognition while diminished cerebrovascular compared with placental resistance predicted poorer cognition, similar to what has been observed in the growth restricted fetus. Further investigation is needed to confirm these hypothesis-generating findings.
Abstract 18710: Spotty Calcifications in Coronary Arteries - What Does it Reflect?
Authors: Eirild Espeseth, Ole Ingemann Hansen, Rita Ullerup, Jesper Thygesen, Annie Vesterby Charles, Erling Falk
Journal: Circulation (2014)

Introduction: Previous studies have documented that the presence of “spotty” calcification in coronary plaques is associated with a higher likelihood of developing acute coronary syndrome (ACS). On the other hand, plaques responsible for stable angina are more calcified than plaques responsible for ACS. The risk of coronary heart disease and mortality increase with increasing total coronary artery calcium scores determined by non-contrast computed tomography (CT). However, the relationship between the pattern of calcification and the morphological features of the plaque remains largely unknown. Aim: To examine the relationship between radiological and morphological features of coronary atherosclerotic plaques obtained postmortem. Methods: We collected 17 coronary arteries from forensic autopsies. The arteries were scanned using a cabinet x-ray system and CT. Up to 12 sites in each artery, with and without calcification, were selected, and processed for plastic embedding and microscopic examination with pr...
A snapshot of genetic lineages of Mycobacterium tuberculosis in Ireland over a two-year period, 2010 and 2011
Authors: M M Fitzgibbon, N Gibbons, E Roycroft, S Jackson, J O’Donnell, D O’Flanagan, T R Rogers
Journal: Eurosurveillance (2013)

Binary file ES_Abstracts_Final_ECDC.txt matches
Abstract 3920: Understanding the molecular nature of cancer cell lines
Authors: Lysa A. Volpe, Anupreet Bal, John Foulke, Michael Jackson, Luping Chen, Fang Tian
Journal: Cancer Research (2014)

Abstract Large-scale cancer genome programs have generated rich data of genetic abnormalities observed in thousands of clinical patient tumors, which provides a major opportunity to develop a landscape of molecular aberrations across tumor types and propose new therapeutic targets. Although human tumor cell lines have been important tools for the cancer researcher for decades, there is a lack of bio-functional validation of genetic alterations and systematic molecular characterization across commonly used cell lines in this genomic age. To meet the need of applying cancer genome knowledge to facilitate basic and translational cancer research, an updated and accurate knowledge of the cell lines in use, particularly from a molecular viewpoint, is critical for in vitro studies. Here, we show systematic molecular characterization and clustering of 90 authenticated human tumor cell lines, which represent the most common human cancer types found in the clinic, such as lung, breast, colon, pancreatic, skin cancer and so on. By next generation sequencing and molecular profiling, those tumor cell lines were fully analyzed to capture the driver gene mutations, DNA copy number variations, gene expressions, protein expressions and relevant cell signaling pathway activations. In addition to driver mutations such as BRAF V600, KRAS G12, PI3K E545 and EGFR T790, the gene copy number amplifications of AKT, FGFR, MET, ERBB2 and deletion of PTEN are presented in this work. Moreover, correlating with the verified genetic alternations, the endogenous basal levels of protein expression and signaling pathway activations within the cells were analyzed by western blot and immunofluorescence staining. A set of 6 wild type control cell lines that were derived from either normal tissues or tumors were characterized in parallel. Furthermore, live cell growth kinetics was continually monitored by label-free cell based assay. Finally, the cell lines are clustered into 10 genetic alteration panels according to driver genes, critical protein kinases, or key components of signaling pathways. Cell lines are essential models for progressing our understanding of the cancer genome, as they allow for the functional and biological validation of the genetic alterations proposed by NGS data. The genetic alteration tumor cell panels and their molecular signature profiles provide powerful tools to accelerate the discoveries in basic cancer research, compound screening, biomarker selection, pathway analysis, and targeted therapeutic development. Citation Format: Lysa A. Volpe, Anupreet Bal, John Foulke, Michael Jackson, Luping Chen, Fang Tian. Understanding the molecular nature of cancer cell lines. [abstract]. In: Proceedings of the 105th Annual Meeting of the American Association for Cancer Research; 2014 Apr 5-9; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2014;74(19 Suppl):Abstract nr 3920. doi:10.1158/1538-7445.AM2014-3920
Abstract 12622: Aortic Pulse Wave Velocity is Associated With Measures of Sub-Clinical Disease in Several Arterial Beds
Authors: Thais Coutinho, Stephen T Turner, Kent R Bailey, Iftikhar J Kullo
Journal: Circulation (2010)

Introduction: Arterial stiffness is associated with adverse cardiovascular events in patients with hypertension. Hypothesis: We hypothesized that aortic pulse wave velocity (aPWV), an established m...
Simian immunodeficiency virus-specific cytotoxic T lymphocytes and cell-associated viral RNA levels in distinct lymphoid compartments of SIVmac-infected rhesus monkeys
Authors: Marcelo J. Kuroda, Jörn E. Schmitz, Aruna Seth, Ronald S. Veazey, Christine E. Nickerson, Michelle A. Lifton, Peter J. Dailey, Meryl A. Forman, Paul Racz, Klara Tenner-Racz, Norman L. Letvin
Journal: Blood (2000)