Therapeutic advances for people with delusions will come from greater specification and empirical investigation
Authors: Philippa Garety
Journal: World Psychiatry (2015)

Phenomenological accounts of delusions focus on the experiences of people – not the delusional content but its mode, manner or form. The emphasis on the detailed description and in-depth exploration of how the person experiences the self and the world, at times of disturbance and distress, is important. Phenomenology has much to teach mental health professionals about recognizing and validating patients' anomalous experiences and their emotional impact. Furthermore, Sass and Byrom 1 offer some elegantly formulated ideas about how information is processed by some people with delusions (their "hyposalience hypothesis") and possible links to certain neurocognitive accounts of delusions. But do these ideas point towards therapeutic advances? I do not think so. There is much cognitive research on delusions which has informed and influenced cognitive behaviour therapy (CBT), but which appears neglected or even misinterpreted by Sass and Byrom. The cognitive approach, in common with these authors, does not view delusions as unitary phenomena, but it differs in that it also tests empirically the hypothesized mechanisms of cause and persistence of different delusion types. The most striking example concerns persecutory delusions, a common, clinically important delusion type. The recent cognitive research on persecutory delusions is not correctly represented by what Sass and Byrom call "the paranoia paradigm", i.e., "the tendency to view literal beliefs about external threat or attack as constituting the prototypical instance of delusion". On the contrary, the purpose is to understand the causal factors implicated in distinct types of delusion and thence to develop targeted interventions 2. Thus, recent research has examined persecutory, grandiose and religious themed delusions to explore hypothesized differences (for example, 3, 4). There is highly replicated evidence, in dozens of independently conducted studies, of reasoning biases in people with delusions, demonstrating, in comparison to control groups, the tendency to gather less information under conditions of uncertainty (or "jumping to conclusions") (see 2, 5 for reviews). I agree that it is possible, as Sass and Byrom note, that the "jumping to conclusions" bias is partially reflected in their concept of an "anything goes mentality". Related to, but distinct from "jumping to conclusions" is a limited reflectiveness about one's own reasoning, which we have called poor belief flexibility – a relative incapacity to reflect on one's judgements, to review and reconsider first impressions and to consider alternatives. Recent evidence suggests that this over-reliance on rapid automatic thinking, at the expense of slower reflective thinking – adopting a two process model of reasoning, as in Kahneman's Thinking, Fast and Slow 6 – is an important mechanism of persecutory delusion persistence and change. A randomized study with 100 people with schizophrenia spectrum psychosis and paranoid thinking demonstrated that we can help people with persecutory delusions to become aware of thinking fast, and to slow down their thinking, thereby reducing their paranoia; this points the way forward for new therapeutic strategies 7. It is of note, perhaps contrary to Sass and Byrom's assumption about the role of emotions underpinning grandiosity, that grandiose delusions are even more strongly characterized by the "jumping to conclusions" reasoning bias than are persecutory delusions 3. But this is emphatically not to deny the importance of emotions in both grandiose and persecutory delusions 3. Sass and Byrom are incorrect in asserting that the paranoia paradigm emphasizes only reasoning biases. Cognitive models of delusions are multifactorial, and research has shown how emotional processes are also active as causal mechanisms of persecutory delusions. Large scale epidemiological research, experiments and interview-based longitudinal studies have investigated social and psychological mechanisms of paranoid thinking and persecutory delusions (for example, 8-10). Emotional processes are clearly important. For example, Wickham et al 10, in a study of 7,000 members of the general public, found that multiple social and economic indices of deprivation predicted the occurrence of paranoia, and that this was partially mediated by measures of interpersonal trust and stress. Another study which followed 300 patients with schizophrenia spectrum psychosis over 12 months showed that a negative self-concept predicted the persistence and severity of persecutory delusions 8. An experimental investigation of how cannabis triggers paranoia showed that anomalies of experience and negative affect are the most likely mechanisms of action in causing paranoia 9. Studies such as these lead directly to new therapeutic approaches to delusions. It is a travesty to suggest, as do Sass and Byrom, that CBT therapists working with people with delusions would endorse the idea that "proffering counter-evidence [can] really be the true therapeutic element in successful CBT for psychosis". Indeed, this was never the case. Very early, it was recognized that presenting counter-evidence is a strikingly unproductive way to work with delusions 11. Rather, the therapy has always involved understanding the grounds for the person's belief – the unusual experiences and events underpinning it – while validating and empathizing with emotional distress; and exploring with the patient, collaboratively, alternative possibilities, cognitive, emotional and behavioural, in the light of the person's history and social environment. More recently, informed by the more precise empirical evidence of mechanisms of specific symptom persistence, whether of reasoning biases, negative affect or negative self-concept, the CBT approach is to work with the process (if you like, with the mode or manner of the thinking rather than the content) and thereby to alleviate the delusion and its accompanying distress and impact on everyday life 2.