MECHANISM OF THE TOXIC EFFECTS FROM COMBINED USE OF CALCIUM AND DIGITALIS
Authors: J. S. Golden, William A. Brams
Journal: Annals of Internal Medicine (1938)

Article1 January 1938MECHANISM OF THE TOXIC EFFECTS FROM COMBINED USE OF CALCIUM AND DIGITALISJ. S. GOLDEN, M.D., WILLIAM A. BRAMS, M.D.J. S. GOLDEN, M.D., WILLIAM A. BRAMS, M.D.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-11-7-1084 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe administration of calcium with digitalis was considered a safe combination to enhance diuresis and to increase the effects of digitalis by Berliner,1Billigheimer2and Singer.15Recently, however, Bowers and Mengle4reported sudden death in two patients who received calcium intravenously after previous administration of digitalis, and similar results were noted in animals that received a similar combination. Available experimental evidence points to either a synergistic effect or an additive phenomenon as the underlying factor for such untoward results. Lloyd1reported the electrocardiographic changes observed on himself during intravenous administration of calcium chloride, using first 50 c.c. of a 1...Bibliography1. BERLINER K: The effect of calcium injections on the human heart, Am. Jr. Med. Sci., 1936, cxci, 117. CrossrefGoogle Scholar2. BILLIGHEIMER E: The effect and relationship of calcium and digitalis, Klin. Wchnschr., 1929, viii, 724. CrossrefGoogle Scholar3. BILLIGHEIMER E: Regulationsmechanismus des vegetativen Nervensystems, Klin. Wchnschr., 1931, x, 686. CrossrefGoogle Scholar4. BOWERSMENGLE JOHA: The additive effect of calcium and digitalis, Jr. Am. Med. Assoc., 1936, cvi, 1151. CrossrefGoogle Scholar5. CUSHNY AR: The action and uses in medicine of digitalis and its allies, 1925, Longmans Green and Co., London, p. 91. Google Scholar6. EDENSHUBER EJE: Digitalis Bigeminus, Deutsch. Arch. f. klin. Med., 1916, cxviii, 476. Google Scholar7. FISCHER H: Beiträge zur Frage des Synergismus zwischen Digitalis- und Calciumwirkung, Arch. f. exper. Path. u. Pharmakol., 1928, cxxx, 194. CrossrefGoogle Scholar8. ISSEKUTZ : Über Aufnahme und Speicherung der Digitalis-substanzen im Herzen, Arch. f. exper. Path. u. Pharmakol., 1915, lxxviii, 155. CrossrefGoogle Scholar9. LIEBERMAN AL: Comparative studies on calcium gluconate and other calcium salts, Jr. Am. Med. Assoc., 1931, xcvii, 15. CrossrefGoogle Scholar10. LIEBERMAN AL: Studies on calcium, Jr. Pharm. and Exper. Therap., 1930, xl, 65. Google Scholar11. LIEBERMAN AL: Studies on calcium, Jr. Pharm. and Exper. Therap., 1933, xlvii, 183. Google Scholar12. LLOYD WD: Danger of intravenous calcium therapy, Brit. Med. Jr., 1928, i, 662. CrossrefGoogle Scholar13. MANDELSTAMM M: Über den Zusammenhang zwischen Digitalis- und Calciumwirkung, Ztschr. f. d. gesamt. exper. Med., 1926, li, 633. CrossrefGoogle Scholar14. SCHUNTERMANN CE: Experimentelle Untersuchungen über den Synergismus zwischen Calcium und Digitalis am intakten Warmbluter, Ztschr. f. d. gesamt. exper. Med., 1935, xcvi, 520. CrossrefGoogle Scholar15. SINGER G: Das Kalzium in der Herztherapie, Wien. klin. Wchnschr., 1921, xxxiv, 247. Google Scholar16. WALTERSBOWLER WJP: Preoperative preparation of patients with obstructive jaundice, Surg., Gynec. and Obst., 1924, xxxix, 200. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Chicago, Illinois*Received for publication May 22, 1937.From the Cardiovascular Department, Michael Reese Hospital, Chicago, Ill. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byMineralstoffwechsel und KreislaufMineralstoffwechsel und KreislaufVelocity of Blood Flow in Health and DiseaseELECTROCARDIOGRAPHIC CHANGES DURING HEMODIALYSIS, WITH OBSERVATIONS ON CONTRIBUTION OF ELECTROLYTE DISTURBANCES TO DIGITALIS TOXICITY*ROBERT M. KOHN, M.D., JOHN E. KILEY, M.D.Digitalis Poisoning and Its TreatmentTHE INFLUENCE OF CALCIUM AND POTASSIUM IONS ON THE TOXICITY OF OUABAINThe Use of Electrocardiograms in MedicineTOXIC MANIFESTATIONS OF CALCIUM THERAPY IN HEART FAILUREMeasurement of circulation time with calcium gluconate in patients receiving digitalis, with electrocardiographic studiesThe use of magnesium sulfate in the measurement of circulation time 1 January 1938Volume 11, Issue 7Page: 1084-1088KeywordsCalciumChloridesElectrocardiography Issue Published: 1 January 1938 PDF downloadLoading ...