CLINICAL EXPERIENCES WITH A NEW MERCURIAL DIURETIC FOR SUBCUTANEOUS ADMINISTRATION
Authors: J B VANDER VEER, P T KUO, D S MARSHALL
Journal: Annals of Internal Medicine (1950)

Article1 November 1950CLINICAL EXPERIENCES WITH A NEW MERCURIAL DIURETIC FOR SUBCUTANEOUS ADMINISTRATIONJOSEPH B. VANDER VEER, M.D., F.A.C.P., P. T. KUO, M.D., DAVID S. MARSHALL II, M.D.JOSEPH B. VANDER VEER, M.D., F.A.C.P.Search for more papers by this author, P. T. KUO, M.D.Search for more papers by this author, DAVID S. MARSHALL II, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-33-5-1215 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptOrganic mercurial compounds are the most powerful diuretics known. They have become an important agent in the treatment of edema, especially that of chronic congestive heart failure. DeGraff and his associates have shown that the addition of a theophylline group to the mercurial compounds enhances the diuretic effect of these substances and reduces their toxicity.1The three currently used preparations containing theophylline—Mercuzanthin, Salyrgan-theophylline, and Mercuhydrin—possess local irritating properties and require deep intramuscular or intravenous injections. With these routes of administration, a number of severe local reactions2and fatal cardiac toxicity1, 3, 4, 5, 6have been reported with the use...Bibliography1. Higgins WH: Acute toxic effects of mercurial diuretics, J. A. M. A. 119: 1182, 1942. CrossrefGoogle Scholar2. DeGraffNadler ACJE: A review of the toxic manifestations of mercurial diuretics, J. A. M. A. 119: 1006, 1942. CrossrefGoogle Scholar3. WexlerEllis JLB: Toxic reactions to intravenous injections of mercurial diuretics, Am. Heart J. 27: 86, 1944. CrossrefGoogle Scholar4. PinesSanabriaHernandez Arriens IART: Mercurial diuretics; addition of magnesium sulfate to prevent toxic effects of their intravenous administration, Brit. Heart J. 6: 197, 1944. CrossrefMedlineGoogle Scholar5. Kauffman RE: Immediate fatalities after intravenous mercurial diuretics, Ann. Int. Med. 28: 1040, 1948. LinkGoogle Scholar6. Oettlé AG: Sudden death after intravenous injection of a mercurial diuretic, Brit. M. J. 2: 530, 1947. CrossrefMedlineGoogle Scholar7. LehmanTaubeKing RAHEE: A comparative study of the local toxic action of mercurial diuretics. To be published. Google Scholar8. Lehman RA: Further studies on the acute toxicity of mercurial diuretics, Proc. Soc. Exper. Biol. and Med. 64: 428, 1947. CrossrefMedlineGoogle Scholar9. BorgCraig JFDM: Experiences with a mercurial diuretic for subcutaneous injection, Proc. Central Soc. Clin. Res. 21: 82, 1948. Google Scholar10. BattermanUttermanDeGraff RCDAC: The subcutaneous use of Thiomerin, a new mercurial diuretic for treatment of congestive heart failure. To be published. Google Scholar11. PollStein DJE: Untoward effects of diuresis, Arch. Int. Med. 58: 1087, 1936. CrossrefGoogle Scholar12. Ben-Asher S: On the toxicity of the mercurial diuretics: observations on 18 cases with suggestions for prevention of toxic reactions, Ann. Int. Med. 25: 711, 1946. LinkGoogle Scholar13. Marshall FA: Tetany following mercurial diuresis, J. A. M. A. 133: 1007, 1947. CrossrefMedlineGoogle Scholar14. DeGraff AC: Diuretics, J. A. M. A. 136: 1025, 1947. CrossrefGoogle Scholar15. Keith NM: The pharmacopoeia and the physician; action and use of diuretics, with special reference to mercurial compounds, J. A. M. A. 107: 2047, 1936. CrossrefGoogle Scholar16. SollmannSchreiber TNE: The diuretic effects of various mercurial treatments, Am. J. Physiol. 93: 689, 1930. Google Scholar17. Bartram EA: Experimental observations on effect of various diuretics when injected directly into the renal artery of dog, J. Clin. Investigation 11: 1197, 1932. CrossrefMedlineGoogle Scholar18. ChristianBartram HAEA: Experimental observations on the action of diuretics, Trans. Ass. Am. Physicians 47: 292, 1932. Google Scholar19. Herrmann GR: Myocardial insufficiency; mechanism and management with data on a new and safer mercurial diuretic, J. A. M. A. 140: 509, 1949. CrossrefMedlineGoogle Scholar20. KlineSeymour EMWB: Systemic reactions to mercurial diuretics, Am. J. M. Sc. 203: 874, 1942. CrossrefGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: *Received for publication September 6, 1949.From the Department of Cardiology, Division of Medicine, Pennsylvania Hospital, Philadelphia, Pennsylvania.The materials used in this study were supplied by Campbell Pharmaceutical Co., New York, New York. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byQuecksilberhaltige DiureticaPresent Day Treatment of Congestive Heart Failure 1 November 1950Volume 33, Issue 5Page: 1215-1223KeywordsDiureticsEdemaHeart failureHospital medicineIntravenous injectionsRoutes of administration ePublished: 1 December 2008 Issue Published: 1 November 1950 PDF downloadLoading ...