tbuckley/cabot-search huggingface dataset:
Juvenile myelomonocytic leukemia displays mutations in components of the RAS pathway and the PRC2 network
Authors: Aurélie Caye, Marion Strullu, Fabien Guidez, Bruno Cassinat, Steven Gazal, Odile Fenneteau, Elodie Lainey, Kazem Nouri, Saeideh Nakhaei-Rad, Radovan Dvorsky, Julie Lachenaud, Sabrina Pereira, Jocelyne Vivent, Emmanuelle Verger, Dominique Vidaud, Claire Galambrun, Capucine Picard, Arnaud Petit, Audrey Contet, Marilyne Poirée, Nicolas Sirvent, Françoise Méchinaud, Dalila Adjaoud, Catherine Paillard, Brigitte Nelken, Yves Reguerre, Yves Bertrand, Dieter Häussinger, Jean-Hugues Dalle, Mohammad Reza Ahmadian, André Baruchel, Christine Chomienne, Hélène Cavé
Journal: Nature Genetics (2015)
Disseminated superficial actinic porokeratosis*
Authors: DONALD J. PIROZZI, ALBERT ROSENTHAL
Journal: British Journal of Dermatology (1976)

Journal Article Disseminated superficial actinic porokeratosis: ANALYSIS OF AN AFFECTED FAMILY Get access DONALD J. PIROZZI, DONALD J. PIROZZI Division of Dermatology, Department of Medicine, Hahnemann Medical College, Philadelphia, PA. 19102, U.S.A. Search for other works by this author on: Oxford Academic Google Scholar ALBERT ROSENTHAL ALBERT ROSENTHAL Division of Dermatology, Department of Medicine, Hahnemann Medical College, Philadelphia, PA. 19102, U.S.A. Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 95, Issue 4, 1 October 1976, Pages 429–432, https://doi.org/10.1111/j.1365-2133.1976.tb00846.x Published: 01 October 1976
Cardiovascular effects of exercise training in an animal model of COPD
Authors: Erlend Hassel, Anne Marie Ormbostad Berre, Anne Jarstein Skjulsvik, Ulrik Wisløff, Sigurd Loe Steinshamn
Journal: European Respiratory Journal (2014)

Exercise has been shown to improve cardiac function in COPD, but little is known about mechanisms involved.

Aim: 

Study the effects of exercise on the cardiovascular system in a mouse model of COPD.

Methods: 

42 female A/JOlaHsd mice were randomized to exposure to either cigarette smoke (CS) or air (FA) for 6 h/day, 5 d/w for 14 weeks. The mice were then kept sedentary (Sed) or put through treadmill interval training (IT) for 4 weeks. Echocardiography was performed and the mice were then killed and the lungs were histomorphometrically analyzed. Airspace enlargement was assessed by mean linear intercept (MLI) and sections stained with antibodies to smooth muscle actin/vonWillenbrand were used to quantify degree of pulmonary artery remodeling.

Results: 

View this table:



CS exposure led to significant airspace enlargement (P=.026). IT led to increased VO2peak (p<0.001). TAPSE was decreased by CS exposure (p=0.008), and attenuated by interval training (p<0.001). Pulmonary vessel muscularization was reduced by IT (p=0.04). There were no significant effects on left ventricle.

Conclusions: 

In this COPD model we found that smoke exposure led to significant reduction in right ventricular function, and this reduction was attenuated by treadmill running. A reduction of pulmonary vessel muscularization due to exercise training may contribute to this improvement in right ventricular function.
Hypertension after renal transplantation.
Authors: M R First, J F Neylan, L L Rocher, A Tejani
Journal: Journal of the American Society of Nephrology (1994)

Hypertension is a frequent complication after organ transplantation in both children and adults and is a significant risk factor for the development of cardiovascular disease and graft dysfunction. There are multiple mechanisms responsible for the development of posttransplant hypertension. In the precyclosporine era, chronic rejection was the most common cause. The introduction of cyclosporine A has increased the prevalence of hypertension in solid organ transplant recipients. Cyclosporine increases renal vascular resistance by causing vasoconstriction of the afferent arteriole. From a pathophysiologic point of view, a calcium channel blocker should be used as the initial therapy in patients with cyclosporine-associated hypertension. Hypertension needs to be treated aggressively in all transplant recipients in an attempt to minimize allograft and cardiovascular damage.
6- Versus 24-Month Dual Antiplatelet Therapy After Implantation of Drug-Eluting Stents in Patients Nonresistant to Aspirin
Authors: Martine Gilard, Paul Barragan, Arif A.L. Noryani, Hussam A. Noor, Talib Majwal, Thomas Hovasse, Philippe Castellant, Michel Schneeberger, Luc Maillard, Erwan Bressolette, Jaroslaw Wojcik, Nicolas Delarche, Didier Blanchard, Bernard Jouve, Olivier Ormezzano, Franck Paganelli, Gilles Levy, Joël Sainsous, Didier Carrie, Alain Furber, Jacques Berland, Oliver Darremont, Hervé Le Breton, Anne Lyuycx-Bore, Antoine Gommeaux, Claude Cassat, Alain Kermarrec, Pierre Cazaux, Philippe Druelles, Raphael Dauphin, Jean Armengaud, Patrick Dupouy, Didier Champagnac, Patrick Ohlmann, Knut Endresen, Hakim Benamer, Robert Gabor Kiss, Imre Ungi, Jacques Boschat, Marie-Claude Morice
Journal: Journal of the American College of Cardiology (2014)
Adrenergic and Muscarinic Receptors in the Human Heart
Authors: Otto-Erich Brodde, Martin C. Michel
Journal: Pharmacological Reviews (1999)

Cardiac function is controlled by the autonomic nervous system (i.e., the sympathetic and the parasympathetic nervous systems), which act via adrenoceptors and muscarinic acetylcholine receptors, respectively. At least nine adrenoceptor subtypes and five muscarinic receptor subtypes exist. In recent
German ministers resign over BSE
Authors: Annette Tuffs
Journal: BMJ (2001)

The current crisis over cows infected with bovine spongiform encephalopathy (BSE) has cost two German ministers their jobs. After the Green health minister, Andrea Fischer, handed in her resignation, the Social Democrat agriculture minister, Karl-Heinz Funke, was forced to resign as well because of apparent problems in handling the BSE crisis.

So far, BSE has been diagnosed in 12 cows in …
Reply from Authors re: Bas W.G. van Rhijn, Mark A. Behrendt, Kees Hendricksen, Theo H. van der Kwast. Toward Optimal Prediction of Prognosis in T1 Urothelial Carcinoma of the Bladder. Eur Urol 2015;68:833–4
Authors: Oliver Patschan, Gottfrid Sjödahl, Gunilla Chebil, Kristina Lövgren, Martin Lauss, Sigurdur Gudjonsson, Petter Kollberg, Pontus Eriksson, Mattias Aine, Mårten Fernö, Fredrik Liedberg, Mattias Höglund
Journal: European Urology (2015)
Suppression of B-Lymphocyte Function by T-Lymphocytes in Patients With Advanced Lung Cancer&lt;xref ref-type="fn" rid="FN2"&gt;2&lt;/xref&gt;&lt;xref ref-type="fn" rid="FN3"&gt;3&lt;/xref&gt;
Authors: M Venkataraman, D S Rao, R D Levin, M P Westerman
Journal: JNCI Journal of the National Cancer Institute (1985)

The ability of B-lymphocytes to produce immunoglobulins in response to pokeweek mitogen stimulation was studied in 21 untreated stage III lung cancer patients by culture of their mononuclear cells in vitro. The number of immunoglobulin-producing cells was significantly lower in 20 of the 21 patients when compared to responses shown by normal control subjects. In contrast, the proliferative responses of many of the patients were within the normal range. When the T-lymphocytes of these patients were irradiated with 1,250 rad to eliminate the suppressor T-cell activity and then cultured with autologous B-cells, the number of immunoglobulin-producing cells was enhanced to the normal range in 7 of the 18 patients. These results indicate that B-cell function is impaired in most patients with advanced lung cancer. They also suggest that, in addition to suppression by radiosensitive suppressor T-cells, other mechanisms are involved in the observed B-cell functional abnormality.
Effect of age on therapeutic outcome in advanced diffuse histiocytic lymphoma: the Southwest Oncology Group experience.
Authors: D O Dixon, B Neilan, S E Jones, D A Lipschitz, T P Miller, P N Grozea, H E Wilson
Journal: Journal of Clinical Oncology (1986)

To study the influence of chronologic age on treatment outcome in patients with advanced, diffuse large-cell (histiocytic) lymphoma (DHL), we reviewed the results of two recent Southwest Oncology Group (SWOG) clinical trials. From 1974 to 1982, members entered 307 eligible patients treated with cyclophosphamide, doxorubicin, vincristine, and prednisone (CHOP) with or without bleomycin, and CHOP with or without immunotherapy using BCG, levamisole, or both. Complete response (CR) rates declined progressively with advancing age: 65% in those under 40, 60% in the 40 to 54 age group, 55% in the 55 to 64 age group, and 37% in those 65 and older (P = .001). Likewise, survival decreased significantly in older patients: medians were 101 +, 52, 34, and 16 months, respectively (P less than .001). Treatment guidelines included an initial dose reduction of 50% for patients aged 65 or older and for younger patients with bone marrow compromise. Despite protocol specifications, 23 of 81 patients aged 65 or older received initial full-dose therapy. When these patients were compared with younger patients on whom full-dose chemotherapy was started, survival curves, but not CR rates, were still significantly different. There were no significant differences in duration of CR or frequency of treatment complications. These data suggest that older age is associated with a worse prognosis in advanced DHL. Moreover, the initial dose reduction for patients aged 65 or older may have contributed to their inferior outcomes.
Abstract 1927: Role of Cardiac Magnetic Resonance Imaging in Patients with Myocarditis: Does late Enhancement have Prognostic Value?
Authors: Esther Perez-David, Miguel Angel, Garcia Fernandez, Ignacio Gomez-Anta, Jose A Larena, Jose Juan, Gomez de Diego, Inaki Lekuona, Javier Lafuente, Sonia Velasco, Eva Laraudogoitia
Journal: Circulation (2006)
Assessment of alveolar clearance with technetium-99m-DTPA radio-aerosol in patients who are active, passive and former smokers; preliminary study
Authors: Yavuz Selim Intepe, Seyhan Karacavus
Journal: European Respiratory Journal (2012)

Objective: Smoking is the most important risk factor for pathological changes such as increased inflammation of lungs, fibrosis of airway wall and destruction of alveolar barriers.Recent studies show strong relationship between passive smoking and pulmonary diseases.In our study we investigate alveolar clearance levels in active,passive and former smokers with technetium-99m-DTPA radioaerosol inhalation scintigraphy.  Methods: 82 patients with smoking related complaints to chest disease clinic were taken in study. 52(%63.5) were female and 30(%36.5) were male. Mean age was 51.3(±)13. Patients were divided into three groups as active, former smokers and passive. Patients who never smoked and did not expose to passive were accepted as control group. Also patients were divided into subgroups as copd, asthma and healthy.In control group smokers 7(%17), nonsmokers 14(%34) and passive were 20(%41). Mucociliary clearance were evaluated with parameters of T1/2, cap value ve penetration index.  Results: A significant difference was stated in healthy group between smokers and passive (p=0.05) and between smokers and nonsmokers (p=0.04).Also a significant difference was determined in patients of copd and asthma in terms of T 1/2 ve cap values between smokers with passive(0,04) and former smokers(p=0,02).There was no significant difference between former and passive smokers.  Conclusion: Our study shows that smoking distrupt alveolo-capillary membrane function and increase mucociliary clearance.In the presence of comorbid disease only active smoking increases clearance.There is also increased clearance in passive smokers compared with nonsmokers.
Pulmonary cancer by level of emphysema and airway wall thickness in subjects with and without COPD
Authors: Ane Aamli, Miriam Gjerdevik, Thomas Grydeland, Per Bakke
Journal: European Respiratory Journal (2014)

Objective:  To examine whether emphysema and airway wall thickness are risk factors to incidence of pulmonary cancer, independent of current smoking status, pack years, gender and age in subjects with and without COPD.   Methods:  We used data from a cohort of 947 ever-smokers, aged 40-75 years, (49% with COPD), examined in 2003/04. The examination included CT thorax, lung function measurements and questionnaires on smoking history. These data were merged with data from the Norwegian Cancer Register in a follow-up study over 8 years.   Results:  Altogether 29 subjects were diagnosed with pulmonary cancer during the follow-up period (27 among the COPD patients and 2 among those without COPD). The median (25/75percentiles) level of emphysema in those diagnosed with pulmonary cancer was 16.65% (4.64/22.33) and 1.41 (0.40/6.07) in those not diagnosed with pulmonary cancer. Mean (SD) airway wall thickness (AWT) in those with and without pulmonary cancer were 0.48 (0.03) and 0.49 (0.03). The hazard ratio for being diagnosed with pulmonary cancer was 1.06 (95%CI: 1.03-1.09) per percentage points increase in level of emphysema after adjusting for gender, age, smoking and pack years. There was no emphysemaXpackyears interaction in risk of pulmonary cancer. AWT did not predict pulmonary cancer independently.   Conclusion:  Level of emphysema was an independent risk factor to incidence of pulmonary cancer while airway wall thickness was not.
Pigmentary Traits, Ethnic Origin, Benign Nevi, and Family History as Risk Factors for Cutaneous Malignant Melanoma&lt;xref ref-type="fn" rid="FN2"&gt;2&lt;/xref&gt;
Authors: C D Holman, B K Armstrong
Journal: JNCI Journal of the National Cancer Institute (1984)

The roles of constitutional factors and benign nevi in causation of malignant melanoma were examined in a case-control study of 511 patients and 511 matched controls in Western Australia. The strongest risk factor was the number of palpable benign nevi on a subject's arms. Compared to the risk of melanomas for persons having no palpable nevi on the arms, the relative risk of melanoma was 2.0 for persons with 1-4 nevi, 4.0 for persons with 5-9 nevi, and 11.3 for persons with 10 or more nevi (P less than .0001). Of the several pigmentary traits known to have associations with melanoma, inability to tan was the most important. Susceptibility to sunburn and hair color also had significant effects that were independent of tanning ability; however, after these traits were controlled, measured skin color and eye color had no additional effects. A reduced risk of melanoma was observed in persons having two or more Southern European grandparents [odds ratio (OR) = 0.39; P = .025]. Persons of Celtic origin did not have a significantly increased risk (OR = 1.18). Possession of one or more affected blood relatives was related to an increased risk of melanoma (OR = 2.69; P less than .0001). The effects of pigmentary traits, benign nevi, ethnic origin, and family history as risk factors were largely independent of one another.
Urinary aquaporin-2 is elevated in infant atopic dermatitis
Authors: Z.H. Di, Y.N. Lv, L. Zhang, Y.X. Hong, H.D. Chen, X.H. Gao, J. Xu
Journal: British Journal of Dermatology (2010)

Conflicts of interest: none declared. Madam, One of the key features of atopic dermatitis (AD) is increased transepidermal water loss (TEWL),1, 2 a phenomenon attributable partly to impaired barrier function of the skin due to some genetic defects such as filaggrin gene (FLG) mutations, or to inflammatory status in AD.1 Remarkable loss of body fluid would induce a series of systemic regulatory reactions. The functional antidiuretic hormone (ADH)–aquaporin (AQP)‐2 axis is a major regulatory system to keep water balance. AQP‐2 mediates water transport across the apical plasma membrane of the renal collecting ducts. Kidney AQP‐2 expression can be estimated quantitatively by urinary excretion of AQP‐2. Moreover, the amount of urinary AQP‐2 (u‐AQP‐2) is positively correlated with the plasma levels of ADH in normal subjects.3 Increased serum ADH was detected in severe AD, a result possibly due to a dehydrated state caused by increased TEWL in these patients.2 Therefore, it is possible that u‐AQP‐2 is altered in AD. We conducted a case–control study to measure the u‐AQP‐2 level in paediatric patients with AD, and assessed its correlation with several clinical and laboratory parameters.
Therapeutic Drug Monitoring of Imatinib in Gist Patients
Authors: R. Marconcini, A. Di Paolo, M. Polillo, L. Galli, A. Antonuzzo, A. Farnesi, A. Sbrana, E. Biasco, L. Derosa, S. Ricci, A. Falcone
Journal: Annals of Oncology (2014)
Study of the cells proliferating in parent versus F hybrid mixed lymphocyte culture.
Authors: P F Piguet, H K Dewey, P Vassalli
Journal: The Journal of Experimental Medicine (1975)

Caryotypic analysis of the cells dividing in mouse parent-hybrid MLC showed an F1 hybrid cell proliferation, which varied depending upon the source of lymphoid cells used: strong in spleen MLC (sometimes equal to that of the parental cells), less marked in lymph node cell MLC, and most often absent in MLC between cortisone-resistant (CR) thymocytes. MLC between parental spleen cells and F1 CR thymocytes showed, however, that in certain conditions of culture F thymocytes can also proliferate. Using parental or F1 spleen cells lacking T lymphocytes, it was found that F1 cell proliferation is entirely dependent upon the presence of parental T cells, but does not require the presence of T lymphocytes among the F1 cells. Immunofluorescence analysis of the blasts observed in one-way MLC showed that about 70% of the parental blasts were T blasts, and 25%B blasts (containing a high proportion of plasmablasts); among the F1 blasts, there was also the same percentage of B blasts and plasmablasts, but many of the T blasts bore only small amounts of T-cell antigen (MTLA), and there was also about 20%of unstained blasts, possibly T blasts bearing MTLA in amounts undetectable by immunofluorescence. The possibility is discussed that the F1 responding T cells belong to a subpopulation performing a suppressive function; MLC lacking F1 T cells showed increased [3H] thymidine incorporation. The proliferation and differentiation of parental and F1 B cells may result mainly from an unspecific, "polyclonal" triggering.
Wild-Type Gross Leukemia Virus. III. Serological Tests as Indicators of Leukemia Risk&lt;xref ref-type="fn" rid="FN2"&gt;2&lt;/xref&gt;
Authors: Tadao Aoki, Edward A. Boyse, Lloyd J. Old
Journal: JNCI Journal of the National Cancer Institute (1968)

Progeny of the cross AKR♀ × C3Hf/Bi ♂ and of the reciprocal cross C3Hf/Bi♀ × AKR ♂ were individually typed at various ages for Gross soluble antigen (GSA) in the blood and observed throughout their life. There was a high correlation between the occurrence of GSA in the blood and development of leukemia. All AKR × C3H progeny were GSA+ at the earliest age tested and the incidence of spontaneous leukemia was 96%. The overall incidence of spontaneous leukemia in progeny of the reciprocal C3H × AKR cross was 56% and the average age of onset was considerably later. The pedigrees of the C3H × AKR progeny revealed two types of families: 1) those in which most members became GSA+ and in which the incidence of leukemia was high, and 2) those in which most members remained GSA− and in which the incidence of leukemia was much lower. The difference in leukemia incidences in these two family types may reflect either maternal immunization or different degrees of virus transmission by various G+ males. When caged or mated with G+ mice, some C3Hf/Bi mice became GSA+ and some C57BL/6 mice produced G antibody. Thus the appearance of GSA in the blood may be attributable to congenital infection, infection in later life, or both.
Multimodality Detection of Metastatic Melanoma
Authors: A K Kuan, F I Jackson, J Hanson
Journal: Journal of the Royal Society of Medicine (1988)

A retrospective evaluation of radionuclide liver and spleen scintigraphy (LS), ultrasonography (US), and computed tomography (CT) was performed in 88 patients who had pathologically proven cutaneous melanoma. In patients who had all three examinations ( n=24), the matrix analysis showed that CT was significantly more sensitive (0.94) in detecting intra-abdominal metastasis when compared to US (0.62, P&lt;0.05) and LS (0.38, P&lt;0.01). Sixty-four patients had only US and LS studies. In this group of patients US was found to be more sensitive than LS, 0.88 and 0.54 respectively ( P&lt;0.01). Furthermore, when CT was compared with US, CT was shown to detect metastases significantly earlier than US ( P=0.03). Overall, CT provided the most accurate means for detecting the intra-abdominal metastases of cutaneous melanoma.
Sleep desaturation and pulmonary hypertension determine sleep-related quality of life and depression in idiopathic pulmonary fibrosis
Authors: Likurgos Kolilekas, Effrosyni Manali, Panagiotis Lyberopoulos, Katerina Vlami, Christina Triantafillidou, Konstantinos Kagouridis, Sotirios Gyftopoulos, Konstantinos Vougas, Mina Gaga, Anna Karakatsani, Manos Alchanatis, Spyros Papiris
Journal: European Respiratory Journal (2013)

Background Sleep breathing disorders are common in IPF and quality of life (QOL) and sleep (QOS) is poor.

Aim To examine the impact of clinical, functional, physiological, cardiac and sleep parameters of IPF-OSA on QOL, QOS and depression and to evaluate the role of QOL-QOS and depression in survival.

Patients and Methods IPF/UIP patients were prospectively studied and followed-up for survival. They performed pulmonary function test, the Epworth sleepiness scale-ESS, cardiac ultrasound, maximal exercise test (CPET),nocturnal polysomnography, evaluation of a. functional status outcomes and quality of life associated with sleepiness by the Functional Outcome of Sleep Questionnaire (FOSQ), b.of sleep difficulty and physical and mental functioning by the Athens Insomnia Scale (AIS) c. severity of depression by the Beck Depression Inventory (BDI).

Results Twenty eight patients (78.6 % male), of 68.4 (± 7.9) years, BMI of 28.6 (± 4.3), ESS of 6.6 (± 3.82), with IPF and AHI>5 were examined. AHI was 16.3 [IQR 7.5-21.3]. FOSQ, AIS and BDI were 0.79 (± 0.2), 0.22 (± 0.2) and 9.13 (± 5.7). MinSaO2 during sleep and maxdiffSaO2 awake-sleep was 81.8±7.3 and 10.7±5.7. FVC%, TLC% and DLCO% values were at 77±17.9, 63.5±12.8 and 43.5±15.6. VO2 peak/kg and SaO2 peak at CPET were 17.0 ml/min/kg±4.1 and 88.4±6.0. RVSP was 35.3±12.4 mmHg. Median survival was 520 days. Significant associations were found between MinSaO2 during sleep, maxdiffSaO2 awake-sleep and RVSP with FOSQ, AIS and BDI. Conclusion IPF-OSA patients present impaired quality of life and sleep and mild to moderate depression significantly related with sleep oxygen desaturation and pulmonary hypertension.