BIOCHEMICAL AND GENETIC ASPECTS OF PRIMAQUINE-SENSITIVE HEMOLYTIC ANEMIA
Authors: A S ALVING, R W KELLERMEYER, A TARLOV, S SCHRIER, P E CARSON
Journal: Annals of Internal Medicine (1958)

Article1 August 1958BIOCHEMICAL AND GENETIC ASPECTS OF PRIMAQUINE-SENSITIVE HEMOLYTIC ANEMIAALF S. ALVING, ROBERT W. KELLERMEYER, ALVIN TARLOV, STANLEY SCHRIER, PAUL E. CARSONALF S. ALVINGSearch for more papers by this author, ROBERT W. KELLERMEYERSearch for more papers by this author, ALVIN TARLOVSearch for more papers by this author, STANLEY SCHRIERSearch for more papers by this author, PAUL E. CARSONSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-49-2-240 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptAcute hemolysis, which may destroy half the red cells within a few days, occurs in approximately 10% of otherwise healthy American Negroes, very rarely in Caucasians,1, 2, 3when 30 mg. primaquine base (twice the dose necessary to cure vivax malaria) are administered daily. Hemolysis is self-limited and is a function of cell age, the older cells being the more susceptible.4, 5Sensitivity to the drug has a familial distribution.6The erythrocytes of sensitive individuals are normal morphologically, and no abnormal erythrocyte antibodies have been detected.7, 8Sensitive individuals react similarly to ingestion of a growing number of agents, including...Bibliography1. HockwaldArnoldClaymanAlving RSJCBAS: Status of primaquine. 4. Toxicity of primaquine in Negroes, J. A. M. A. 149: 1568, 1952. CrossrefMedlineGoogle Scholar2. DernWeinsteinLeRoyTalmageAlving RJIMGVDWAS: The hemolytic effect of primaquine. I. The localization of the drug-induced hemolytic defect in primaquine-sensitive individuals, J. Lab. and Clin. Med. 43: 303, 1954. MedlineGoogle Scholar3. DernBeutlerAlving RJEAS: The hemolytic effect of primaquine. V. Primaquine sensitivity as a manifestation of a multiple drug sensitivity, J. Lab. and Clin. Med. 45: 30, 1955. MedlineGoogle Scholar4. 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Its relation to certain drug-induced anemias, New York Academy of Sciences Conference on Enzymes in Blood, February, 1958. Google Scholar33. AlvingFlanaganCarsonSchrierKellermeyer ASCLPESLRW: Unpublished data. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: *From the Symposium on Genetics, presented at the Thirty-ninth Annual Session of The American College of Physicians, Atlantic City, New Jersey, April 30, 1958.From the University of Chicago, Chicago, Illinois.This work was supported (in major part) by the Research and Development Division, Office of the Surgeon General, Department of the Army, under Contract number DA-49-007-MD-566. Additional support was obtained from Winthrop Laboratories, Inc., New York, N. Y., Parke, Davis & Company, Detroit, Michigan, Eaton Laboratories, Norwich, New York, Abbott Laboratories, North Chicago, Illinois, and the Douglas Smith Foundation, The University of Chicago, Chicago, Ill.Requests for reprints should be addressed to Alf S. Alving, M.D., Department of Medicine, University of Chicago, 950 East 59th St., Chicago 37, Illinois.†GSH, reduced glutathione; TPN, triphosphopyridine nucleotide; TPNH, reduced triphosphopyridine nucleotide; DPNH, reduced diphosphopyridine nucleotide; DPN, diphosphopyridine nucleotide; GSSG, oxidized glutathione. 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YOUNG, M.D., F.A.C.P.ENZYME DEFICIENCY IN HÆMOLYTIC DISEASE OF THE NEWBORNRED-CELL METABOLISM : FUNDAMENTAL AND CLINICAL ASPECTSDrug allergy in pediatric practiceGlucose-6-Phosphate Dehydrogenase and Human Erythrocytes: Characteristics of Glucose-6-Phosphate Dehydrogenase from Normal and Primaquine-sensitive ErythrocytesHEMOLYTIC DISORDERS: SOME HIGHLIGHTS OF TWENTY YEARS OF PROGRESS*†LAWRENCE E. YOUNG, M.D., F.A.C.P. 1 August 1958Volume 49, Issue 2Page: 240-248KeywordsCellsGeneticsGlutathioneHemolytic anemiaIngestionMalariaMolecular biologyPrimaquineSurgeonsTotal parenteral nutrition ePublished: 1 December 2008 Issue Published: 1 August 1958 PDF downloadLoading ...