ALDOSTERONE-SECRETING ADENOMA: REPORT OF A CASE IN A JUVENILE
Authors: Milton G. Crane, John E. Holloway, William G. Winsor
Journal: Annals of Internal Medicine (1961)

Case Reports1 February 1961ALDOSTERONE-SECRETING ADENOMA: REPORT OF A CASE IN A JUVENILEMILTON G. CRANE, M.D., JOHN E. HOLLOWAY, M.D., WILLIAM G. WINSOR, M.D.MILTON G. CRANE, M.D., JOHN E. HOLLOWAY, M.D., WILLIAM G. WINSOR, M.D.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-54-2-280 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptIn 1955 Conn1 described a new disease syndrome called "primary aldosteronism." Since that time approximately 100 instances of this condition have been observed. Reports of many of these‡2-7, 10 have appeared in the literature. Basically, two types of the syndrome have been recognized. In the adult form, adrenal cortical adenomas have been found to be the cause, whereas in the juvenile form the syndrome has been caused by benign hyperplasia of the adrenal cortex.8-11This is a report of a young woman who was first found to have hypertension at the age of 13 years.The report contains the results of...Bibliography1. Conn JW: Presidential address. II. Primary aldosteronism, a new clinical syndrome. J. Lab. Clin. Med. 45: 6, 1955. Google Scholar2. ChalmersFitzgeraldJamesScarborough TMMGAHH: Conn's syndrome with severe hypertension. Lancet 1: 127, 1956. CrossrefGoogle Scholar3. MaderIseri IJLT: Spontaneous hypopotassemia, hypomagnesemia, alkalosis and tetany due to hypersecretion of corticosterone-like mineralocorticoid. Amer. J. Med. 19: 976, 1955. CrossrefMedlineGoogle Scholar4. SkanseMollerGydellJohanssonWolff BFKSHB: Observations on primary aldosteronism. Acta med. Scandinav. 158: 181, 1957. CrossrefMedlineGoogle Scholar5. AlstedHolberg GP: Potassium-losing nephritis—primary aldosteronism. Acta med. Scandinav. 161: 487, 1958. CrossrefMedlineGoogle Scholar6. CraneVogelRichland MGPJKJ: Observations on a presumptive case of primary aldosteronism. J. Lab. Clin. Med. 48: 1, 1956. MedlineGoogle Scholar7. CraneShortPeterson MGGJE: Observations on a case of primary aldosteronism. Amer. J. Med. 24: 313, 1958. CrossrefMedlineGoogle Scholar8. van BuchemDoorenbosElings FSHHS: Primary aldosteronism due to adrenocortical hyperplasia. Lancet 2: 335, 1956. CrossrefGoogle Scholar9. HoltenPetersen CVP: Malignant hypertension with increased secretion of aldosterone and depletion of potassium. Lancet 2: 918, 1956. CrossrefGoogle Scholar10. BartterBiglieri FCEG: Primary aldosteronism: clinical staff conference at the National Institutes of Health. Ann. Intern. Med. 48: 647, 1958. LinkGoogle Scholar11. MellingerTherianKlineDitzlerSmithFine RBITJRG: Primary aldosteronism, Henry Ford Hosp. Med. Bull. 6: 1, 1958. MedlineGoogle Scholar12. ThreefootBurchReaser SGP: The biological decay periods of sodium in normal man, in patients with congestive heart failure, and in patients with the nephrotic syndrome as determined by Na22 as the tracer. J. Lab. Clin. Med. 34: 1, 1949. MedlineGoogle Scholar13. NeherWettstein RA: Physicochemical estimation of aldosterone in urine. J. Clin. Invest. 35: 800, 1956. CrossrefMedlineGoogle Scholar14. Reddy WJ: Modification of the Reddy-Jenkins-Thorn method for the estimation of 17-hydroxycorticoids in urine. Metabolism 3: 489, 1954. MedlineGoogle Scholar15. NorymberskiStubbsWest JKRDHF: Assessment of adreno-cortical activity by assay of 17-ketogenic steroids in urine. Lancet 1: 1276, 1953. CrossrefMedlineGoogle Scholar16. DrekterHeislerScismSternPearsonMcGavack IJAGRSSTH: The determination of urinary steroids. I. The preparation of pigment-free extracts and a simplified procedure for the estimation of total 17-ketosteroids. J. Clin. Endocr. 12: 55, 1952. CrossrefMedlineGoogle Scholar17. WestEllisScott PMFWBL: A simplified method for determining the excretion rate of uropepsin. J. Lab. Clin. Med. 39: 159, 1952. MedlineGoogle Scholar18. FoyeFeichtmeir LVTV: Adrenal cortical carcinoma producing solely mineralocorticoid effect. Amer. J. Med. 19: 966, 1955. CrossrefMedlineGoogle Scholar19. SpauldingOilleGornall WBWAAG: Mineralocorticoid-like disturbance associated with adrenal metastases from a bronchogenic carcinoma. Ann. Intern. Med. 42: 444, 1955. LinkGoogle Scholar20. BrooksMillsPrunty RVIHFT: A new urinary steroid related to mineral metabolism. Lancet 2: 925, 1956. CrossrefGoogle Scholar21. GenestKoiwNowaczynskiLeboeuf JEWG: Further studies on urinary aldosterone in human arterial hypertension. Proc. Soc. Exp. Biol. Med. 97: 676, 1958. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: *Received for publication September 14, 1959.From the Department of Internal Medicine, College of Medical Evangelists, Los Angeles, California, and The Respiratory and Rehabilitation Center for Poliomyelitis, Rancho Los Amigos Hospital, Downey, California.†This investigation was supported in part by research grant H-2195 from the National Institutes of Health, and by a grant from the Los Angeles County Heart Association.Requests for reprints should be addressed to Milton G. Crane, M.D., 1720 Brooklyn Avenue, Los Angeles 33, California.‡No attempt will be made to include all case reports in the bibliography. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byPrimary Hyperaldosteronism with Normokalaemia Secondary to an Adrenal Adenoma (Conn's Syndrome) in a 12 Year-old BoyConn syndrome in a child, caused by adrenal adenomaAldosterone-secreting adrenal cortical adenoma in an 11-year-old child and collective review of the literatureAldosteronoma in childhood: A review of clinical features and managementAldosterone-secreting adrenal cortical adenoma in an 11-year-old child and collective review of the literaturePrimary hyperaldosteronism in childhood due to unilateral macronodular hyperplasia. Case report.Pathologic Features of Childhood Adrenocortical TumorsPathologic Features of Childhood Adrenocortical TumorsChildhood Hypertension Due to Adrenocortical DisordersAldosteronoma in a child with localization by adrenal vein aldosterone: Collective review of the literatureHypertension, Oral Contraceptive Agents, and Conjugated EstrogensM. G. CRANE, M.D., F.A.C.P., J. J. HARRIS, M.D., F.A.C.P., WILLIAM WINSOR III, M.D.On the pathogenesis of metabolic alkalosis in hyperaldosteronismClinical characteristics of primary aldosteronism from an analysis of 145 cases 1 February 1961Volume 54, Issue 2Page: 280-291KeywordsAdenomasExcretionHeartHospital medicineHypertensionPoliomyelitisRehabilitation medicineResearch grantsSalivaYoung adults Issue Published: 1 February 1961 PDF downloadLoading ...