tbuckley/cabot-search huggingface dataset:
La yogathérapie de groupe
Authors: B. Auriol
Journal: Psychotherapy and Psychosomatics (1972)

In this work the author, having recalled the urgency for a non-dualistic approach to the human organism, even in the psychotherapic field, outlines the basic structure of a new technique: 'group yoga-therapy'. He goes on to specify the instructions and prohibitions of this technique: it is dangerous for neurotics and psychotics to practise by themselves; but yoga is having promising results when practised in group, under the supervision of a psychotherapist. One could draw a parallel between yoga-therapy and the techniques to obtain harmony through muscular tonus. One must only suggest therapeutic yoga for those who have no vertebral injuries or who are very interested (motivated). The author indicates a lasting transformation after several months of practise. Women seem to benefit more than men. Neurotics profit more than psychotics. Finally some future perspectives are evoked.
STUDIES ON THE ETIOLOGY OF PRIMARY ATYPICAL PNEUMONIA
Authors: Monroe D. Eaton, William van Herick, Gordon Meiklejohn
Journal: The Journal of Experimental Medicine (1945)

Significant increases in neutralizing antibodies were demonstrated in 42 of a total of 69 persons with a clinical diagnosis of primary atypical pneumonia. Detailed titrations of virus-neutralizing antibodies in a representative group of 28 patients are presented. Increases of four- to 64-fold were demonstrated. Acute-phase titers were 4 or less in 83 per cent and convalescent titers were 16 or over in 86 per cent of these cases. Only about half of the number of patients having increases in neutralizing antibodies also developed cold agglutinins and agglutinins for the indifferent streptococcus No. 344. Patients from the Eastern United States as well as those from the Pacific Coast were shown to develop virus-neutralizing antibodies. Patients with pneumococcal pneumonia and pneumonias caused by influenza virus type A or viruses of the psittacosis group did not have significant increases in neutralizing antibodies for the virus of atypical pneumonia. Cold agglutinins appeared in 3 cases of type A influenzal pneumonia. Sera from persons with atypical pneumonia, when tested against the 3 most prevalent respiratory viruses isolated from cotton rats and hamsters, failed to neutralize these agents or showed no significant change in neutralization titer.
Replacement of routine liver biopsy by procollagen III aminopeptide for monitoring patients with psoriasis receiving long-term methotrexate: a multicentre audit and health economic analysis
Authors: R.J.G. Chalmers, B. Kirby, A. Smith, P. Burrows, R. Little, M. Horan, J.M. Hextall, C.H. Smith, M. Klaber, S. Rogers
Journal: British Journal of Dermatology (2005)

Background Patients receiving long‐term methotrexate for psoriasis are at risk of developing hepatic fibrosis. Repeated liver biopsy has long been regarded as the only reliable method of detecting this and it is still recommended by the American Academy of Dermatology (AAD). More recently, monitoring by serum procollagen III aminopeptide (PIIINP) measurement (Orion Diagnostica, Espoo, Finland) has been advocated as a means of significantly reducing the need for liver biopsy. Objectives To assess the validity of guidelines developed in Manchester for the use of PIIINP to monitor patients with psoriasis receiving long‐term methotrexate; to assess the anticipated benefits to patients of introducing this change in practice, including reduction in requirement for liver biopsy; and to determine the impact of its introduction on healthcare costs. Methods A multicentre audit was conducted over a 24‐month period to compare the healthcare costs and outcomes of two intervention groups from centres where serial PIIINP measurement was employed with those of two control groups from centres in which AAD guidelines were followed. Results A sevenfold reduction in the need for liver biopsy was observed in the two intervention groups (n = 166; 0·04 and 0·02 biopsies/patient/year, respectively) compared with the two control groups (n = 87; 0·26 and 0·30 biopsies/patient/year, respectively). Abnormalities of sufficient severity to influence management were identified in one in five patients biopsied in the main intervention group compared with one in 16 in the control groups. The overwhelming majority of patients surveyed expressed a preference for being monitored by methods that would minimize the need for liver biopsy. The adoption of PIIINP for monitoring would result in significant cost savings. Conclusions This audit has shown that patients managed by the Manchester protocol using serial PIIINP measurement and selective liver biopsy were not disadvantaged in comparison with those managed according to AAD guidelines; they were subjected to sevenfold fewer liver biopsies without evidence that important liver toxicity was missed in the process. If PIIINP monitoring were widely adopted, methotrexate would become a more acceptable option for many patients who are dissuaded from considering it because of the threat of repeated liver biopsy; it would also result in significant savings to the healthcare budget.
Esophageal Intramural Pseudodiverticulosis with Symptomatic Stricture: Mediastinitis and Papillomatosis as a Complication of Endoscopic Intervention
Authors: D. Brenke, I. Wanzar, U. Will
Journal: Endoscopy (2006)

Patients with esophageal intramural pseudodiverticulosis (EIP) usually develop symptoms because of complications such as gastroesophageal reflux, motility disorders, infections, strictures, fistulas, bleeding, or perforation.
RELATIONSHIP BETWEEN MITRAL REGURGITATION AND LEFT VENTRICULAR REMODELING: IMPORTANCE OF 3D ECHOCARDIOGRAPHIC ASSESSMENT OF VENTRICULAR SHAPE IN DILATED CARDIOMYOPATHY
Authors: Francesco Maffessanti, Paola Gripari, Karima Addetia, Gloria Tamborini, Manuela Muratori, Lynn Weinert, Victor Mor-Avi, Mauro Pepi, Roberto Lang
Journal: Journal of the American College of Cardiology (2014)
Recruitment of the cytoplasmic adaptor Grb2 to surface IgG and IgE provides antigen receptor–intrinsic costimulation to class-switched B cells
Authors: Niklas Engels, Lars Morten König, Christina Heemann, Johannes Lutz, Takeshi Tsubata, Sebastian Griep, Verena Schrader, Jürgen Wienands
Journal: Nature Immunology (2009)
Smoking Cessation Treatment for Patients With Schizophrenia
Authors: Jean Addington, Nady el-Guebaly, William Campbell, David C. Hodgins, Donald Addington
Journal: American Journal of Psychiatry (1998)

OBJECTIVE: This study was an uncontrolled trial to assess the efficacy of a smoking cessation group program modified for individuals with schizophrenia. METHOD: Fifty outpatients with schizophrenia were divided into five groups who met separately for seven weekly sessions of a smoking cessation program. The subjects' schizophrenic and extrapyramidal symptoms were assessed before the group sessions began and after they had been completed. Assessments of smoking were made at those times and at 3-month and 6-month follow-ups. RESULTS: Forty-two percent of the subjects had stopped smoking at the end of the group sessions; 16% remained abstinent at 3 months, and 12% at 6 months. These changes were statistically significant. There was no change in the positive or negative symptoms of schizophrenia. CONCLUSIONS: The results suggest that it is possible for individuals with schizophrenia to stop smoking. (Am J Psychiatry 1998; 155:974–976)
Remarks on the Treatment of Placenta Praevia
Authors: J. Murphy
Journal: BMJ (1884)

several miles, and go upstairs without discomfort.The superficial vessels were much less distinct, and the skin looked healthy.The respiratory and cardiac sounds were normal, and the pulse was full and regular.I.-4 10 REMARKs.-The omplete relief of all the ciest.symptoms is the main point of interest in the case.The condlition of the patient before the opertion was certainly very critical.The weight of the tumour embarrassed the respiration, and preventecl due expansion of the chest.Cardiac failure was, however, the great source of danger.The heart was greatly taxed in sustaining.the circulation, and the serious retardation of the venous current was evident from the distension of the veins, az;d the chronic obstruction of the pulmonary system.The absence of marked valvular insufficiency and renal complication rendered'the result of-operative interfcrence fairly favourable.Ether was careftilly administered during the operation, and repeated hypodermic injections were employed to re- lieve the urgent symptoms of cardiac failure.
Morphologic observations of contact‐induced lysis of EBV‐infected B lymphocytes by autologous hand mirror T cells
Authors: William J. Thomas, Bertrand Duval‐Arnould, William J. Creegan, Harold R. Schumacher, David S. Forman, Douglas M. Strong
Journal: American Journal of Hematology (1982)

Abstract To study the possible immunologic role of hand mirror lymphocytes (HML) in the control of Epstein‐Barr virus (EBV)‐infected B lymphocytes in patients with infectious mononucleosis (IM), we studied the in vitro interactions of these cells by time‐lapse video light microscopy. Peripheral blood T lymphocytes isolated from three patients in the early recovery phase of IM were mixed with their autologous EBV‐infected B cells. Motile lymphocytes with their characteristic hand mirror shape were observed to attach by their uropods to the B cells. The HML remained attached for variable periods ranging from 45‐75 min. Following detachment, B cells that were in contact with HML underwent lysis. Mixtures of T cells from healthy donors and EBV‐infected cell lines exhibited only rare uropod formation with no attachment or lysis of B cells. The present experiment indicates that contact‐induced lysis of EBV‐infected B lymphocytes is operative in IM and that this process is mediated by the HML.
Familial Chilblain Lupus Due to a Novel Mutation in the Exonuclease III Domain of 3′ Repair Exonuclease 1 (<i>TREX1</i>)
Authors: Claudia Günther, Nicole Berndt, Christine Wolf, Min Ae Lee-Kirsch
Journal: JAMA Dermatology (2014)

Familial chilblain lupus is a rare, autosomal dominant form of lupus erythematosus characterized by cold-induced inflammatory lesions at acral locations presenting in early childhood. Familial chilblain lupus is usually caused by a mutation in TREX1 (3' repair exonuclease 1).We report on a family with dominant chilblain lupus segregating a novel TREX1 mutation (c.585C>G; H195Q) within the highly conserved exonuclease (Exo) III domain. Affected family members experienced cold-induced chilblain lesions of varying degrees, ranging from bluish-red infiltrations to mutilating necrotic ulcerations. In addition, all patients showed signs of systemic disease, such as arthritis, lymphopenia, or antinuclear antibodies. An increased expression of myxovirus resistance protein A in the skin and induction of interferon-stimulated genes in peripheral blood cells demonstrated activation of type I interferon.This case further implicates type I interferon-dependent innate immune activation in the pathogenesis of TREX1-associated familial chilblain lupus. Unlike previously reported TREX1 mutations, which affect the Exo I or Exo II domains, the mutation presented here alters the Exo III domain, suggesting a particular role of mutations within the catalytic Exo domains in the pathogenesis of familial chilblain lupus. The high prevalence of extracutaneous manifestations, along with activation of type I interferon, underlines the systemic nature of familial chilblain lupus.
Calcium and Ischemic Injury
Authors: Franklin H. Epstein, Joseph Y. Cheung, Joseph V. Bonventre, Charles D. Malis, Alexander Leaf
Journal: New England Journal of Medicine (1986)

ISCHEMIC diseases of the heart, kidney, and brain continue to be the primary causes of mortality and morbidity in the United States and other Western industrialized nations. The magnitude of the problem has stimulated much research directed at identifying the proximate causes of ischemic cell death. It is hoped that a clear understanding of ischemia-induced derangements of cell function will allow more rational prevention and therapy.In the past two decades, many potentially damaging factors, such as ATP depletion, plasma-membrane phospholipid degradation, activation of autolytic systems, cellular acidosis, superoxide-induced membrane damage, and mitochondrial dysfunction, have been implicated as playing a . . .
Deregulating emergency contraception. Genitourinary clinics offer out of hours service.
Authors: R Sockanathan
Journal: BMJ (1993)

Daily treatment with cannabinoids results in tolerance to many, but not all, of their behavioral and physiological effects. The present studies investigated the effects of 7-day exposure to 10 mg/kg/day Δ9-tetrahydrocannabinol (THC) on the diuretic and antinociceptive effects of THC and the synthetic cannabinoid AM4054. Comparison studies determined diuretic responses to the κ-opioid agonist U50,488 and furosemide. Following determination of control dose-response functions, mice received 10 mg/kg/day THC for 7 days, and dose-response functions were redetermined 24h, 7 days, or 14 days later. THC and AM4054 had biphasic diuretic effects under control conditions with maximum effects of 30 and 35 ml/kg urine, respectively. In contrast, antinociceptive effects of both drugs increased monotonically with dose to &gt;90% MPE. Treatment with THC produced 9- and 3-fold rightward shifts of the diuresis and antinociception dose-response curves for THC and, respectively, 7- and 3-fold rightward shifts in the AM4054 dose-response functions. U50,488 and furosemide increased urine output to &gt;35 ml/kg under control conditions. The effects of U50,488 were attenuated following 7-day treatment with THC, whereas the effects of furosemide were unaltered. Diuretic effects of THC and AM4054 recovered to near-baseline levels within 14 days after stopping daily THC injections, while tolerance to the antinociceptive effects persisted longer than 14 days. The tolerance induced by 7-day treatment with THC was accompanied by a 55% decrease in the Bmax value for cannabinoid CB1 receptors. These data indicate that repeated exposure to THC produces similar rightward shifts in the ascending and descending limbs of cannabinoid diuresis dose-effect curves, and to antinociceptive effects, while resulting in a flattening of the U50,488 diuresis dose-effect function.
Smoking and cotton dust effects in cotton textile workers: an analysis of the shape of the maximum expiratory flow volume curve.
Authors: E N Schachter, M C Kapp, L R Maunder, G Beck, T J Witek
Journal: Environmental Health Perspectives (1986)

Cotton textile workers have an increased prevalence of both obstructive and restrictive lung function patterns when compared to control subjects. Similar abnormal lung function patterns may occur with other respiratory diseases, notably those associated with cigarette smoking. The shape of the maximum expiratory flow volume (MEFV) curve has been used to characterize patterns of lung function abnormality. We defined a new functional parameter (angle beta) related to the shape of the MEFV curve in order better to characterize the respiratory effects of cotton dust exposure. In this study, 477 cotton textile workers, both current smokers and never smokers 45 years and older, were compared to 932 similarly aged control subjects from three communities: Lebanon and Ansonia, CT, and Winnsboro, SC. Smokers, regardless of their occupational exposure of sex, have smaller values of beta than do nonsmokers. Cotton textile workers who have more abnormal lung function than do controls, cannot be distinguished from controls by beta. We suggest that such functional differences between cotton and smoking effects may reflect injury to different portions of the bronchial tree.
Surgical Treatment of Obesity in Adolescence
Authors: Edward H. Livingston
Journal: JAMA (2010)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Is It Always Wrong to Perform Futile CPR?
Authors: Robert D Truog
Journal: New England Journal of Medicine (2010)

Although there is currently much debate about the types of care to which patients are entitled, one thing on which everyone can agree is that nonbeneficial care should be eliminated. Although such care can be hard to define, in some circumstances experienced clinicians can be virtually certain that attempts at resuscitation will fail. In these cases, many argue that hospitals should adopt policies that allow physicians to refuse when families demand futile cardiopulmonary resuscitation (CPR).Several years ago, I cared for a 2-year-old boy who had been born with a large frontal encephalocele. He survived surgical excision but was left . . .
An emerging dialogue among social scientists and neuroscientists on the causal bases of emotion
Authors: Marc D. Lewis
Journal: Behavioral and Brain Sciences (2005)

The target article developed a dynamic systems framework that viewed the causal basis of emotion as a self-organizing process giving rise to cognitive appraisal concurrently. Commentators on the article evaluated this framework and the principles and mechanisms it incorporated. They also suggested additional principles, mechanisms, modeling strategies, and phenomena related to emotion and appraisal, in place of or extending from those already proposed. There was general agreement that nonlinear causal processes are fundamental to the psychology and neurobiology of emotion.
Statin Therapy for Healthy Men Identified as “Increased Risk”
Authors: Michael J. Blaha, Khurram Nasir, Roger S. Blumenthal
Journal: JAMA (2012)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Grippe, New York, 1916
Authors: Gary J. Whitehead
Journal: JAMA (1997)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
A Phase II study of <sup>153</sup>Sm‐EDTMP and high‐dose melphalan as a peripheral blood stem cell conditioning regimen in patients with multiple myeloma
Authors: Angela Dispenzieri, Gregory A. Wiseman, Martha Q. Lacy, Suzanne R. Hayman, Shaji K. Kumar, Francis Buadi, David Dingli, Krista M. Laumann, Jake Allred, Susan M. Geyer, Mark R. Litzow, Dennis A. Gastineau, David J. Inwards, Ivana N. Micallef, Stephen M. Ansell, Luis Porrata, Michelle A. Elliott, Patrick B. Johnston, William J. Hogan, Morie A. Gertz
Journal: American Journal of Hematology (2010)

Multiple myeloma (MM) remains an incurable illness affecting nearly 20,000 individuals in the United States per year. High-dose melphalan (HDM) with autologous hematopoietic stem cell support (ASCT) is one of the mainstays of therapy for younger patients, but little advancement has been made with regards to conditioning regimens. We opted to combine (153)Samarium ethylenediaminetetramethylenephosphonate ((153)Sm-EDTMP), a radiopharmaceutical approved for the palliation of pain caused by metastatic bone lesions, with HDM and ASCT in a Phase II study. Individualized doses of (153)Sm were based on dosimetry and were calculated to deliver 40 Gy to the bone marrow. The therapeutic dose of (153)Sm-EDTMP was followed by HDM and ASCT. Forty-six patients with newly diagnosed or relapsed disease were treated. Study patients were compared to 102 patients contemporaneously treated with HDM and ASCT. Fifty-nine percent of study patients achieved a very good partial response (VGPR) or better. With a median follow-up of 7.1 years, the median overall survival and progression free survival (PFS) from study registration was 6.2 years (95% CI 4.6-7.5 years) and 1.5 years (1.1-2.2 years), respectively, which compared favorably to contemporaneously treated non-study patients. Addition of high-dose (153)Sm-EDTMP to melphalan conditioning appears to be safe, well tolerated, and worthy of further study in the context of novel agents and in the Phase III setting.