tbuckley/cabot-search huggingface dataset:
COARCTATION OF THE AORTA
Authors: J R FONTANETTA
Journal: Annals of Internal Medicine (1947)

Case Reports1 February 1947COARCTATION OF THE AORTAJOSEPH R. FONTANETTA, M.D.JOSEPH R. FONTANETTA, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-26-2-283 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptCoarctation of the aorta is infrequently encountered clinically, although it is one of the most common congenital cardiac anomalies. In Abbott's series of 1000 cases of congenital cardiovascular defects, this condition was noted in 142 instances, being the primary lesion in seventy-nine. Baugh1places the incidence as high as one per thousand in the general population, while Blackford2maintains from his study of necropsy material that the frequency approximates one in 1550 cases. Similarly Levine3has stated that one in every 2000 persons in the general population has this abnormality. Abbott and Weiss4have emphasized the frequency with which this...Bibliography1. BAUCH DD: Coarctation of the aorta, Mississippi Doctor, 1943, xxi, 159. Google Scholar2. BLACKFORD LM: Coarctation of the aorta, Arch. Int. Med., 1928, xl, 1702. Google Scholar3. LEVINE SA: Clinical heart disease, 3rd ed., 1945. Google Scholar4. ABBOTTWEISS ME: The diagnosis of congenital cardiac disease, 1928. Google Scholar5. LEWIS T: Material relating to coarctation of the aorta of the adult type, Heart, 1933, xvi, 205. Google Scholar6. RYTLAND DA: Renal factor in arterial hypertension with coarctation of the aorta, Jr. Clin. Invest., 1938, xvii, 391. CrossrefGoogle Scholar7. BROTCHNER RJ: Etiology of hypertension resulting from coarctation, Arch. Path., 1939, xxviii, 676. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Brooklyn, N. Y.*Received for publication February 26, 1946.From the Merchant Marine Medical Center, 107 Washington Street, New York City.Published with the permission of the Surgeon General of the United States Public Health Service, Washington, D. C. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 February 1947Volume 26, Issue 2Page: 283-287KeywordsAortaArmed forcesLesionsMedical servicesSurgeons ePublished: 1 December 2008 Issue Published: 1 February 1947 PDF downloadLoading ...
Abstract 18520: Job Strain, Job Insecurity, and Incident Cardiovascular Disease in the Women's Health Study
Authors: Natalie Slopen, Robert J Glynn, Julie Buring, Michelle A Albert
Journal: Circulation (2010)

Introduction: Prior research on the relation between work-related stress and cardiovascular disease (CVD) has produced mixed findings. Moreover, a paucity of data exists regarding the long-term ass...
278. Hypoxia Reduces Adenoviral Replication in Cancer Cells by Down-Regulation of Viral Protein Expression
Authors: Teona Pipiya, Harald Sauthoff, Yao Qi Huang, Benjamin Chang, William N. Rom, John G. Hay
Journal: Molecular Therapy (2004)

Successful cancer therapy using replicating viral vectors relies on the spread of virus from infected to uninfected cells. To date, there has been limited clinical success in the use of replicating adenoviruses. In animal models, established xenograft tumors are rarely eliminated despite the persistence of high viral titers within the tumor. Hypoxia is a prevalent characteristic of solid tumors. Adenovirus naturally infects tissues exposed to ambient oxygen concentrations. In addition, the proximity of the virus to blood vessels within persistent xenograft tumors suggests that the hypoxic environment plays an important role in limiting adenoviral replication. We have previously established that hypoxia (1% oxygen) limits adenoviral replication in H1299 and A549 lung cancer cells (Mol Ther 2003; 7: 5 part 2). However, hypoxia did not reduce cell viability or restrict S-phase entry. To further evaluate the mechanism by which hypoxia reduces viral production, the transcription and translation of viral proteins were evaluated in hypoxic and ambient conditions. H1299 and A549 lung cancer cells were infected with wild type adenovirus Ad309 (MOI 10) and incubated for 24h or 48h in ambient (21% oxygen) or hypoxic (1% oxygen) environments. Immunoblotting was performed for two viral proteins, E1a and fiber. For both H1299 and A549 cells the production of E1a and fiber under hypoxic conditions was substantially decreased at 24h and 48h compared to room air controls. In contrast, northern analysis for A549 and H1299 cells showed similar levels of E1a mRNA in room air and hypoxic conditions at 24h. In conclusion, the level of hypoxia similar to that found within tumors reduces the replication of adenoviral vectors by reduction of viral protein expression without a reduction in mRNA levels.
Campaign to reduce waiting lists in Ireland has had little impact
Authors: Doug Payne
Journal: BMJ (2001)

Despite an eight year, multimillion pound campaign to reduce hospital waiting lists in the Republic of Ireland, the Irish government has managed to reduce waiting times in only three adult specialties: cardiac surgery, vascular surgery, and ophthalmology.

Since 1993 the Department of Health has spent more than £Ir120m (£96m; $145m) on the campaign, and, although lists overall have shown a small decline, many patients are having longer waits now than four or five years ago.

Although waiting times for paediatric cardiac surgery have decreased, 60% of such …
Abstract 16738: Correlation Between Appropriate Use of Coronary CT Angiography and Downstream Resource Utilization
Authors: Kavitha Chinnaiyan, Leaden Hickman, Judith A Boura, Ann M DePetris, Patricia Peyser, Gilbert Raff, Brahmajee Nallamothu
Journal: Circulation (2014)

Introduction: Limited data exist regarding the correlation between the appropriateness of use of coronary CT angiography (CTA) and downstream resource utilization (RU). Methods: Data from the Advanced Cardiovascular Imaging Consortium, a statewide CTA registry were linked to Blue Cross Blue Shield of Michigan claims data. Based on the 2010 appropriate use criteria, the group was divided into: appropriate (A), inappropriate (I), uncertain (U) and unclassifiable (UC). CTA findings and RU (hospitalizations, invasive angiography, revascularizations, stress testing) at 1 year were compared. Results: The study group consisted of 2307 patients (A =1582, I = 276, U = 195 and UC = 254). The most common indication among the I group was use of coronary CTA for CAD screening (32%). Compared to the A group, patients in the I group were older and more often male, and had higher prevalence both nonobstructive (&lt;50% stenosis, 69.2% vs. 54.1%, p&lt;0.0001) and obstructive (≥50% stenosis, 27.8% vs. 19.3%, p&lt;0.0001) CAD. No significant difference was noted between the A and I groups with respect to overall downstream resource utilization (46.9% vs. 44.6%, p = 0.47), invasive procedures (15% vs. 15.2%, p = 0.94) or noninvasive testing (43.1% vs. 40.6%, p = 0.44). On multivariate analysis among all patients, the finding of obstructive CAD was the strongest predictor of overall resource utilization (OR 5.33 [95% CI 3.51-8.10]) followed by acute presentation (OR 2.1 [95% CI 1.48-2.98]) ; inappropriate use was not a significant predictor (OR 0.78 [95% CI 0.51-1.19]). Conclusions: In this population-based cohort, 68.5% of patients were appropriately referred for CTA. Appropriate use did not correlate with downstream resource utilization events, which were driven strongly by CTA findings. Additionally, patients deemed inappropriate for CTA had higher burden of CAD, with implications for early detection and prognosis in these patients. Further studies are needed to adjudicate appropriateness of use of coronary CTA.
GRANULOCYTOPENIA FROM SULFANILAMIDE WITH UNUSUAL BLOOD CRISIS AND RECOVERY; CASE REPORT
Authors: J. Shirley Sweeney, L. E. Allday
Journal: Annals of Internal Medicine (1940)

Case Reports1 January 1940GRANULOCYTOPENIA FROM SULFANILAMIDE WITH UNUSUAL BLOOD CRISIS AND RECOVERY; CASE REPORTJ. SHIRLEY SWEENEY, M.D., Sc.D., F.A.C.P., L. E. ALLDAY, M.D.J. SHIRLEY SWEENEY, M.D., Sc.D., F.A.C.P.Search for more papers by this author, L. E. ALLDAY, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-13-7-1241 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptIn an issue of the Journal of the American Medical Association there appeared experimental studies, case reports and an editorial concerning sulfanilamide. Two of these papers1, 2 dealt with the leukocytic response to sulfanilamide and its mode of action. In an interesting and cogent extension of the subject were two case reports3, 4 of fatal intoxication following administration of the drug. Reference was made to two other reports of fatal cases. The subject was reviewed editorially, and one is reminded that the Council on Pharmacy and Chemistry originally advised periodical microscopic examinations of blood of patients taking sulfanilamide.As with...Bibliography1. BIGLERCLIFTONWERNER JAWMM: The leukocyte response to sulfanilamide, Jr. Am. Med. Assoc., 1938, cx, 343. CrossrefGoogle Scholar2. OSGOODBROWNLEE EEIE: Mode of action of sulfanilamide, Jr. Am. Med. Assoc., 1938, cx, 349. CrossrefGoogle Scholar3. SCHWARTZGARVINKOLETSKY WFCFS: Fatal granulocytopenia from sulfanilamide, Jr. Am. Med. Assoc., 1938, cx, 368. CrossrefGoogle Scholar4. BERGHOLTZMAN SM: Fatal granulocytopenia from sulfanilamide, Jr. Am. Med. Assoc., 1938, cx, 370. CrossrefGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Dallas, Texas*Received for publication October 28, 1938. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 January 1940Volume 13, Issue 7Page: 1241-1243KeywordsBloodDrug administrationDrugsIntoxication ePublished: 1 December 2008 Issue Published: 1 January 1940 PDF downloadLoading ...
Umbilical cord blood banks in the UK
Authors: S J Proctor, A M Dickinson, T Parekh, C Chapman
Journal: BMJ (2001)

Allogeneic stem cell transplantation has revolutionised the outcome for a wide range of malignant and non-malignant haematological conditions.1 Of the sources of stem cells, umbilical cord blood, obtained from the placenta directly after delivery, is enriched in stem cells and has a higher proliferative capacity than cells obtained from bone marrow and peripheral blood. 2 3 Like any blood product, however, stem cells from cord blood need an infrastructure for collecting, banking, and matching the donations.

Several cord blood banks and registries have been formed internationally (four of them in the United Kingdom) which collect the cord blood products and perform cryopreservation, tissue typing, and viral assessment. These products can then be accessed after a search of the internet linked databases and the cryopreserved product transported to the transplant centre for use.

Marrow engraftment can occur quite quickly after infusion of cord blood, although it may be delayed in some instances—this depends largely on the cell dose in the sample and the size of the recipient. In the largest series, reported by Rubinstein et al, 562 …
Abstract 15739: Impact of Sleep Apnea Syndrome on Long-term Outcome in Patients with Acute Coronary Syndrome
Authors: Toru Mazaki, Hiroyoshi Yokoi, Yoshimitsu Soga, Masashi Iwabuchi, Hideyuki Nosaka, Masakiyo Nobuyoshi
Journal: Circulation (2010)

Purpose: Sleep apnea syndrome (SAS) is very common risk factor for cardiovascular events. However, the impact of SAS on long-term outcome in patients with acute coronary syndrome (ACS) has not been...
Abstract P203: Evaluation of Appropriate Sedative Agents in Therapeutic Hypothermia for Out-of-Hospital Cardiac Arrest from Multicenter Registry in Japan: J-PULSE-Hypo Registry
Authors: Hideki Arimoto, Hiroshi Rinka, Arito Kaji, Naohiro Yonemoto, Hiroyuki Yokoyama, Ken Nagao, Hiroshi Nonogi
Journal: Circulation (2009)
173. Adenovirus-Mediated Gene Transfer to Mouse and Dog Pancreas In Vivo
Authors: Nicola Brunetti-Pierri, William Cioffi, David Iannitti, Thomas Ng, Donna Palmer, Arthur Beaudet, Milton Finegold, Karen Rice, Dee Carey, Philip Ng
Journal: Molecular Therapy (2004)

Helper-dependent adenoviral vectors (HDAd) are attractive vectors for liver-directed gene therapy because they can mediate sustained, high level transgene expression with negligible long-term toxicity. However, high vector doses are required to achieve efficient hepatic transduction by peripheral intravenous injection due to a nonlinear dose response. Unfortunately, such high systemic doses result in wide spread vector dissemination and dose-dependent activation of the acute inflammatory response which can result in severe and lethal acute toxicity. We hypothesize that this problem can be surmounted by delivering the vector exclusively to the liver thereby permitting high efficiency hepatic transduction with low vector doses and with minimal systemic vector dissemination. To test this hypothesis, we injected HDAd directly into the surgically isolated liver via the portal vein in nonhuman primates. Total hepatic isolation was achieved by occluding hepatic blood inflow from the portal vein and hepatic artery and by occluding hepatic blood outflow at the vena cava. Prior to total hepatic isolation, saline was infused into the portal vein to flush blood out of the liver. The vector was then injected directly into the isolated liver via the portal vein and allowed to dwell for 30 min to prolong exposure to hepatocytes. Following the 30 min dwell time, unabsorbed vector was removed from the liver to minimize systemic dissemination. This was accomplished by infusing saline into the portal vein and collecting the unabsorbed vector from a vena cava catheter. We investigated the safety, feasibility and efficacy of this approach and our results revealed that the surgical procedure was well tolerated in nonhuman primates and that significantly higher hepatic transduction efficiencies can be achieved with relatively low vector doses as compared to those obtained by peripheral intravenous injection. This approach may increase the safety and efficacy of HDAd-mediated, liver-directed gene therapy by minimizing the dose required to achieve efficient hepatic transduction and by minimizing systemic vector dissemination.
Clinical fraud is common
Authors: V. Rippere
Journal: BMJ (1995)

EDITOR,--Britain's lax approach to scientific fraud1 is not an isolated phenomenon but exemplifies its endemic disregard for the veracity of medical discourse generally; this disregard is largely condoned by institutions. Clinical correspondence and case notes commonly display an apparent indifference, sometimes amounting to recklessness, about the accuracy of information represented as fact and the substainability of expressed opinion.

Fraud is fraud whether it consists of inventing research subjects and data or, for example, garbling a …
Formation of the N-Nitroso Derivatives of Six β-Adrenergic-blocking Agents and Their Genotoxic Effects in Rat and Human Hepatocytes
Authors: Luigi Robbiano, Antonietta Martelli, Alessandra Allavena, Mauro Mazzei, Gian Massimo Gazzaniga, Giovanni Brambilla
Journal: Cancer Research (1991)

Six β-adrenergic-blocking drugs, atenolol, metoprolol, nadolol, oxprenolol, propranolol, and sotalol, were found to react with sodium nitrite in HCl solution, yielding the corresponding N -nitrosamines. The genotoxic activity of the six nitrosamines was evaluated in primary cultures of both rat and human hepatocytes; DNA fragmentation was measured by the alkaline elution technique, and DNA repair synthesis by quantitative autoradiography. Positive dose-related responses were produced in cells of both species after 20 h of exposure to the following subtoxic concentrations: NO-propranolol, 0.01–0.1 mm; NO-oxprenolol, 0.03–1 mm; NO-atenolol and NO-metoprolol, 0.1–1 mm; and NO-nadolol and NO-sotalol, 0.3–3 mm. Modest but statistically significant differences between the DNA-damaging potencies for the two species were observed with NO-atenolol and NO-oxprenolol, which were both more active against rat hepatocytes, and with NO-propranolol, which was more active against human hepatocytes. At equal or higher concentrations, the six N -nitrosamines did not produce DNA fragmentation in Chinese hamster lung V79 cells; this indicates that they behave as indirectly acting compounds, which need to be transformed into reactive metabolites in order to exert a genotoxic effect.
Scientists Use Neuroimaging, Genetic Studies to Probe Biology of Tourette Syndrome
Authors: Rebecca Voelker
Journal: JAMA (2004)

Cleveland—In a darkened conference hall, Kirk Frey, MD, PhD, nodded toward the screen showing a slide listing all the published studies on neurochemical changes in the brain related to Tourette syndrome (TS). The list did not take long to read—it contained just 5 citations.
Myocardial Infarction, Clinical Characteristics and Prognosis across Five Renal Function Stages - Data from the Register of Information and Knowledge about Swedish Heart Intensive Care Admissions (RIKS-HIA)
Authors: Karolina Szummer, Pia Lundman, Stefan Jacobson, Staffan Schon, Johan Lindback, Ulf Stenestrand, Lars Wallentin, Tomas Jernberg
Journal: Circulation (2008)

Myocardial Infarction, Clinical Characteristics and Prognosis across Five Renal Function Stages - Data from the Register of Information and Knowledge about Swedish Heart Intensive Care Admissions (RIKS-HIA)
Methylation of the CDH1 promoter as the second genetic hit in hereditary diffuse gastric cancer
Authors: William M. Grady, Joseph Willis, Parry J. Guilford, Anita K. Dunbier, Tumi T. Toro, Henry Lynch, Georgia Wiesner, Kelly Ferguson, Charis Eng, Jae-Gahb Park, Seong-Jin Kim, Sanford Markowitz
Journal: Nature Genetics (2000)
Targeted disruption of the glucose transporter 4 selectively in muscle causes insulin resistance and glucose intolerance
Authors: Ariel Zisman, Odile D. Peroni, E. Dale Abel, M. Dodson Michael, Franck Mauvais-Jarvis, Bradford B. Lowell, Jørgen F.P. Wojtaszewski, Michael F. Hirshman, Antti Virkamaki, Laurie J. Goodyear, C. Ronald Kahn, Barbara B. Kahn
Journal: Nature Medicine (2000)
Value of Ophthalmologic Examination in Diagnosing Temporal Arteritis
Authors: Alexander B. Maish
Journal: JAMA (2002)

on the survivorship effect of the rate of change in the FEV1%. We, like others, 3-5 initially made the logical assumption that patients with CF who have rapid deterioration of FEV1% would have an increased risk of death. It has been hypothesized that the subset of patients with the most rapid decline in FEV1% would gain a survival benefit from lung transplantation. We created theoretical survival models based on this hypothesis that suggested that we might be able to identify appropriate transplantation candidates several years before the optimal moment for transplantation. This would decrease the number of patients who die while on a waiting list, and optimize the use of donated organs. Unfortunately, none of these models are valid because we also found that the rate of decline in FEV1 %i s not a significant predictor of survival. 6 In our previous work, univariate logistic regression analysis showed that rate of decline of FEV1% predicted was not a significant predictor of survival. 6 We now report that, despite the lack of significance, we included the rate of decline of FEV1% predicted in further multivariate analyses because of its clinical appeal. This variable, whether calculated by linear regression or by linear mixed-effects analysis, again was not statistically significant and was excluded in stepwise analysis of variance when FEV1% was also included in candidate models. Because we were initially skeptical of this result, we attempted to use the linear mixed effects model of FEV1% rate of change to predict future FEV1%. We identified 12477 patients in the CF Foundation Patient Registry with 2 to 5 years of pulmonary function data from 1987 through 1992. We generated linear mixed-effects models of the rate of change of FEV1% for each patient and predicted the change in FEV1% for 1993 through 1997. The FIGURE shows the complete inability of the FEV1% rate of change to make that prediction. Because the rate of FEV1% decline was not predictive of survival or even of future FEV1%, as shown here, it was not included in our evaluation of the survival effects of lung transplantation. Based on this additional analysis, we conclude that the rate of decline in FEV1% is not helpful in the selection of patients with CF for lung transplantation.
The Practical Applications of X-Rays.
Authors: Georg William Clarkson Kaye
Journal: JAMA (1923)

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