tbuckley/cabot-search huggingface dataset:
When You Come Into My Room
Authors: Stephen A. Schmidt
Journal: JAMA (1996)

When you come into my hospital room, you need to know the facts of my life that there is information not contained in my hospital chart that I am 40 years married, with 4 children and 4 grandchildren that I am "genetically Lutheran"... with gut disease, like Luther himself that I am a professor that I teach teachers, priests, sisters how to nurture faith in the next generation that I love earthy sensuous life, beauty, travel, eating, drinking J&amp;B scotch, the theater, opera, the Chicago Symphony, movies, all kinds, water skiing, tennis, running, walking, camping that I love loving, the wonder and awe of sexual intimacy that I enjoy gardening, smell of soil in misty rain and scorching sun that I have led a chronic illness group for 12 years When you come into my room, you need to know the losses of my life that I have Crohn's disease
Medical Biography: Recently Published Sources and Guides
Authors: Edward J. Huth
Journal: Annals of Internal Medicine (1972)

The Literature of Medicine1 March 1972Medical Biography: Recently Published Sources and GuidesEdward J. Huth, M.D.Edward J. Huth, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-76-3-517 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptProfessional historians and experienced amateurs with an interest in medical history know where to go when they need biographical data on medicine's greater or lesser figures. But most medical students, writers, teachers, lecturers, and journalists may not know the ready sources of medical biographies that are brief but adequate for their infrequent needs in this area. They will very likely get the right help if they have access to the services of a medical librarian. Without this help, they may waste much time in trying to track down even such simple facts as correct spelling of names, life dates, places... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byMetrication on the Crawl 1 March 1972Volume 76, Issue 3Page: 517-521KeywordsHistory of medicineInformation storage and retrieval ePublished: 1 December 2008 Issue Published: 1 March 1972 PDF downloadLoading ...
Nursing Stresses in the Intensive Care Unit
Authors: James E. D. Gardam
Journal: JAMA (1969)

<h3>To the Editor:—</h3> The report of the Committee on Nursing, "Stresses on the Nurse in an Intensive-Care Unit" (<b>208</b>:332, 1969), recognizes a new problem incurred by nursing staff concurrent with the development of intensive-care units (ICU). A case of paroxysmal auricular tachycardia and a case of acute duodenitis in the intensive-care unit of Clara Maass Memorial Hospital, prompted a review of our personnel practices which may provide partial solutions to some of the problems expressed by Vreeland and Ellis. First, personnel should be selected with care. Although no clearly defined profile of successful ICU nurses exist, we have found them to be young, healthy, well motivated, and energetic to the point of exuberance. They are not always classified as the most "academic" as defined by prior nursing school evaluation but demonstrate nursing ability early in their careers. Ellis and Vreeland recognize the anxiety caused "by insecurity in knowledge or
Changing incidence of trachoma in the West Midlands
Authors: C. H. L. Howells, L. Johnson, K. G. Soni, D. F. Woodhouse
Journal: BMJ (1969)

An increasing incidence of trachoma in an urban Midland population has been shown to be mainly due to immigration of infected carriers from the Punjab. In areas where trachoma is common special clinics should be established for the treatment and follow-up of patients and contacts. Public health measures should be introduced to prevent the spread of the infection. Laboratory methods should be more widely used in the diagnosis and control of trachoma.
Inhibition of collagen synthesis by mononuclear cell supernates.
Authors: S A Jimenez, W McArthur, J Rosenbloom
Journal: The Journal of Experimental Medicine (1979)

Mononuclear cell infiltration and alteration in the connective tissues are prominent features of the inflammatory response in a number of diseases. To determine whether mononuclear cell products can modulate collagen synthesis, human peripheral mononuclear cells from normal donors were isolated by Ficoll-Hypaque gradient centrifugation and then incubated for 48 h with or without phytohemagglutinin. Confluent cultures of normal, human skin fibroblasts were incubated with [14C]proline and various amounts of dialyzed supernates from the mononuclear cell cultures. Labeled, newly synthesized collagen was estimated by [14C]hydroxyproline analysis, collagenase digestion, and chromatography on Agarose A-5m in sodium dodecyl sulfate. The total incorporation of [14C]proline was not significantly affected by addition of the mononuclear cell supernates, but as much as 90% decrease in the synthesis by the fibroblasts of labeled collagen was found relative to controls. Supernates from the phytohemagglutinin-stimulated cultures were more active than those from nonstimulated cells. These results suggest that mononuclear cells can synthesize a factor(s) which can selectively inhibit collagen synthesis.
Effect of digitoxin on cardiac hypertrophy induced by pericardiectomy and exercise
Authors: J. COOKSEY, K. SCHANUEL, H. BOMZE
Journal: Cardiovascular Research (1976)

Removal of the pericardium in combination with a mild exercise programme of swimming resulted in a significant increase in heart weight and heart weight/body weight ratio of young rats. Heart weight/body weight ratios were 3.46+/-0.25 in the sedentary control animals, 4.16+/-0.26 in pericardiectomized animals swimming 2 h each day, and 4.60+/-0.22 in pericardiectomized animals swimming 6h/d. The effect of pericardiectomy on the development of cardiac hypertrophy is additive to that of mild exercise (2h/d) but not to prolonged exercise (6h/d). The administration of digitoxin significantly decreased the development of cardiac hypertrophy in pericardiectomized animals that were exercised for 2 h/d but not those exercised for 6 h/d. These findings further substantiate the physiological effect on the heart of the pericardium. The effects of pericardiectomy should be considered in experimental studies of cardiac hypertrophy and in clinical studies involving cardiac surgery.
ATYPIC HERPES ZOSTER GANGRENOSA, WITH REPORT OF TWO CASES.Read in the Section of Dermatology and Syphilology at the Forty-first Annual Meeting of the American Medical Association, Nashville, Tenn., May, 1890.
Authors: BENJ. MERRILL RICKETTS
Journal: JAMA (1890)

found, however, and Monsell's solution was ap¬ plied.An opening was left for drainage and for the escape of sloughing particles.The bleeding never recurred and the wound healed nicely by
Satisfaction of treatment with biologics is high in psoriasis: results from the Bio-CAPTURE network
Authors: J.M.P.A. van den Reek, P.P.M. van Lüumig, M.E. Otero, J. Zweegers, P.C.M. van de Kerkhof, P.M. Ossenkoppele, M.D. Njoo, J.M. Mommers, M.I.A. Koetsier, W.P. Arnold, B.A.M. Sybrandy-Fleuren, A.L.A. Kuijpers, M.P.M. Andriessen, M.M.B. Seyger, W. Kievit, E.M.G.J. de Jong
Journal: British Journal of Dermatology (2014)

Background Although the effectiveness of biologics for psoriasis has been measured extensively with objective outcome measures, studies based on subjective, patient-reported outcome measures remain scarce. Objectives To investigate satisfaction with medication, as measured by the Treatment Satisfaction Questionnaire for Medication (TSQM) for biologics in daily practice psoriasis care in the first 6 months of treatment; and to identify possible differences in satisfaction with medication between patients experienced (biologics-experienced) and inexperienced (biologics-inexperienced) in the use of biologics. Methods TSQM baseline measurements were compared using measurements taken after 6 months, using the Wilcoxon signed-rank test for paired comparisons. Intention-to-treat with last observation carried forward (ITT with LOCF) and as-treated analyses were performed. The difference between biologics-experienced and biologics-inexperienced patients for TSQM was analysed using ITT with LOCF. At 6 months, outcomes for biologics-experienced and biologics-inexperienced patients were compared using the Mann–Whitney U-test. Results One hundred and six patients were eligible for analysis, and treated with etanercept (n = 34), adalimumab (n = 49) or ustekinumab (n = 23). Fifty-four per cent of patients were biologics-inexperienced. A statistically significant improvement was seen in all domains of the TSQM ('effectiveness', 'side-effects', 'convenience' and 'global satisfaction') by comparison of months 3 or 6 with baseline (all P ≤ 0·02). After 6 months, biologics-inexperienced patients scored better on the 'global satisfaction' domain than biologics-experienced patients (P < 0·01). Conclusions We provide a prospective, longitudinal analysis of TSQM for biologics in daily practice psoriasis care. High satisfaction rates were achieved. The 'effectiveness' and 'convenience' domains showed the most room for improvement.
PROGNOSTIC IMPACT OF FUNCTIONAL MITRAL REGURGITATION EARLY IMPROVEMENT IN PATIENTS WITH IDIOPATHIC DILATED CARDIOMYOPATHY RECEIVING OPTIMAL MEDICAL TREATMENT
Authors: Davide Stolfo, Marco Merlo, Bruno Pinamonti, Stefano Poli, Marta Gigli, Giulia Barbati, Enrico Fabris, ndrea Di Lenarda, Gianfranco Sinagra
Journal: Journal of the American College of Cardiology (2014)
Clinical and neurohormonal correlates and prognostic value of serum prolactin levels in patients with chronic heart failure
Authors: John T. Parissis, Dimitrios Farmakis, Katerina Fountoulaki, Antonios Rigas, Maria Nikolaou, Ioannis A. Paraskevaidis, Vassiliki Bistola, Koula Venetsanou, Ignatios Ikonomidis, Maria Anastasiou‐Nana, Dimitrios T. Kremastinos, Gerasimos Filippatos
Journal: European Journal of Heart Failure (2013)
Immunologic identification of lymphocyte subsets in experimental murine myocarditis with encephalomyocarditis virus. Different kinetics of lymphocyte subsets between the heart and the peripheral blood, and significance of Thy 1.2+ (pan T) and Lyt 1+, 23+ (immature T) subsets in the development of myocarditis.
Authors: C Kishimoto, K Kuribayashi, K Fukuma, T Masuda, N Tomioka, W H Abelmann, C Kawai
Journal: Circulation Research (1987)

To clarify the immune mechanism in myocarditis, immunofluorescence techniques with laser flow cytometry were used to examine serial changes in lymphocyte subsets in the heart, spleen, and peripheral blood of DBA/2 and BALB/c mice inoculated with encephalomyocarditis virus (Experiment I). B cells were identified by staining with fluorescein isothiocyanate-labelled rabbit anti-mouse immunoglobulin. T-cell subsets were identified with rat anti-Thy 1.2, and nonpolymorphic Lyt 1 and Lyt 2 monoclonal antibodies plus fluorescein isothiocyanate-labelled anti-mouse immunoglobulin. On days 7 and 14 postinfection, the percentage of Thy 1.2+ (pan T) cells in both strains had decreased in the peripheral blood; B cells showed no significant changes throughout the entire period. On the other hand, Thy 1.2+ (pan T) and Lyt 1+, 23+ (precursor and immature) T cells appeared to occupy the major portion of the myocardium on days 7 and 14 when congestive heart failure developed. To confirm this, serial immunohistologic studies (immunoperoxidase staining) of the hearts of DBA/2 and BALB/c mice with encephalomyocarditis virus-induced myocarditis were performed (Experiment II). In Experiment II, most of the stained cells in the hearts of both strains were Thy 1.2 positive and Lyt 1 and Lyt 2 positive on days 7 and 14. Thus, Experiments I and II demonstrated that lymphocytes at the site of inflammation in acute viral myocarditis carried antigenic markers that differed from those of peripheral lymphocytes and suggested that Thy 1.2+ (pan T) cells, especially the Lyt 1+, 23+ subset (immature T cells and T-cell subset precursors) were involved in the development of myocarditis in these animals.
Abstract 4407: Structural and biochemical analysis of ERBB4 mutations in cancer.
Authors: Kari Kurppa, Konstantin Denessiouk, Mark S. Johnson, Klaus Elenius
Journal: Cancer Research (2013)

Abstract Genes encoding the ErbB receptor tyrosine kinases (EGFR/ERBB1, ERBB2, ERBB3, and ERBB4) are key regulators of cellular proliferation, survival, and differentiation, and thus represent potent proto-oncogenes. In particular, mutations or copy number variations of EGFR or ERBB2 are present in human malignancies and serve as biomarkers for targeted therapies. Recently, somatic mutations of the ERBB4 gene have been identified in various cancer types, such as non-small cell lung cancer and melanoma, indicating a role for mutated ERBB4 as a potential drug target. However, the structural and functional consequences of the ERBB4 mutations remain to be fully elucidated. We used both a structural as well as a biochemical approach to address the functional effects the ERBB4 mutations for ErbB4 signaling. The structural effects of the mutations were assessed in both active and inactive ErbB4 conformation in silico. The biochemical effects of the mutations on ErbB4 signaling were analyzed in vitro using assays measuring the kinase activity of ErbB4 as well as activation of downstream signaling pathways. Although all structural subdomains of ERBB4 have been reported to be affected by somatic mutations, our analyses indicated that the mutations cluster to regions important for activation of the receptor, such as the dimerization interface and the kinase domain active site. Some of the mutations were structurally non-hazardous and probably represent passenger mutations. Consistently, the biochemical analyses indicated for the presence of both activating and functionally non-significant mutations. These observations suggest for the presence of both driver as well as passenger mutations of ERBB4 in human cancer. Citation Format: Kari Kurppa, Konstantin Denessiouk, Mark S. Johnson, Klaus Elenius. Structural and biochemical analysis of ERBB4 mutations in cancer. [abstract]. In: Proceedings of the 104th Annual Meeting of the American Association for Cancer Research; 2013 Apr 6-10; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2013;73(8 Suppl):Abstract nr 4407. doi:10.1158/1538-7445.AM2013-4407
Reproductive Endocrinology
Authors: MORTIMER B. LIPSETT
Journal: Annals of Internal Medicine (1970)

The increased sensitivity of the radioimmunoassays for plasma gonadotrophins and saturation assays for plasma steroids has facilitated the analysis of the events of the menstrual cycle and the alterations of these in disease. The early follicular rise of follicle-stimulating hormone (FSH) is correlated with follicular development, the midcycle surge of luteinizing hormone with ovulation. Changes in plasma steroids indicate whether steroidogenesis by the developing follicle and corpus luteum are normal. Several clinical entities are examined using these methods. The functional life-span of the corpus luteum of pregnancy was 8 to 10 weeks with maximum function 4 weeks after ovulation. The conventional oral contraceptives containing an estrogen and progestin inhibit cyclic gonadotrophin secretion and thereby prevent ovulation. One of the conditions associated with infertility, the short luteal phase, is due to low FSH levels with consequent poor follicular development and inadequate corpus luteum function. Clomiphene citrate induces ovulation in some women with secondary amenorrhea by causing a release of FSH, thereby simulating the normal early follicular rise of FSH.
Vascular Occlusive Disorders: Medical and Surgical Management
Authors: Norman R. Hertzer
Journal: JAMA (1982)

According to its editor, this text is intended to provide comprehensive source material for physicians, and presumably for surgeons who are charged with the management of patients having vascular occlusive disorders. The principal authors, most of whom have been associated with the Walter Reed Army Medical Center or the Uniformed Services University of the Health Sciences, have attempted to meet this objective by dividing the book into three sections. Two of these, comprising 205 of the 481 pages, are devoted to the mechanisms of basic hemostasis, problems of hypercoagulability, and the clinical application of anticoagulants such as heparin, warfarin sodium, the dextrans, antiplatelet drugs, and thrombolytic agents. The remainder of the text addresses the diagnostic presentation and treatment options for specific vascular diseases, including ischemic heart disease, stroke, mesenteric vascular occlusion, acute lower extremity arterial insufficiency, and venous thrombosis. Each chapter contains an extensive list of references at least through
Link found between Agent Orange and chronic lymphocytic leukaemia
Authors: C. Marwick
Journal: BMJ (2003)

Reviewing recently published scientific evidence, a committee of the US Institute of Medicine has concluded that a positive association exists between exposures to herbicides used as defoliants from 1962 to 1971during the Vietnam war and the risk of developing chronic lymphocytic leukaemia.

The report is the fourth in a series of reviews that the institute has conducted at Congress's request since 1996 of the health effects of these defoliants. Earlier reports had linked Hodgkin's …
Diagnostic Smear of Acid-Fast Bacilli
Authors: Allan L. Goldman, Demetrios G. Halkias
Journal: Annals of Internal Medicine (1975)

Comments and Correction1 August 1975Diagnostic Smear of Acid-Fast BacilliALLAN L. GOLDMAN, M.D., DEMETRIOS G. HALKIAS, PH.D.ALLAN L. GOLDMAN, M.D.Search for more papers by this author, DEMETRIOS G. HALKIAS, PH.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-83-2-283_1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: The reliability (specificity and sensitivity) of the acid-fast bacilli smear in the detection of tuberculosis has recently been questioned (1). In the specimens reviewed by Boyd and Marr, smears were screened using the auramine-rhodamine fluorescent technique, a sensitive but nonspecific test. Positive smears were restained using the Kinyoun method, a refinement of the old Ziehl-Neelsen technique. This method is more specific but less sensitive than the fluorescent technique. To be considered positive, the smear had to be positive by both methods. Specimens were also cultured. Through paired sample techniques, they analyzed 4510 specimens. Fifty-eight smears were positive...References1. BOYDMARR JJ: Decreasing reliability of acid-fast smear techniques for detection of tuberculosis. Ann Intern Med 82: 489-492, 1975 LinkGoogle Scholar2. MESSABLAIRTULL CEA: Computer files and analyses of laboratory data from tuberculous patients. Am Rev Resp Dis 108:813-818, 1973 MedlineGoogle Scholar3. NARAINSUBBA RAOCHANDRASEKHAR RMP: Microscopy positive and microscopy negative cases of pulmonary tuberculosis. Am Rev Resp Dis 103:761-773, 1971 MedlineGoogle Scholar4. CHANCHIALEE WMK: Bacteriological measures for the detection of cases of pulmonary tuberculosis. Bull WHO 45: 551-558, 1971 MedlineGoogle Scholar5. TRUANTBRETTTHOMAS JWW: Fluorescence microscopy of tubercle bacilli stained with auramine and rhodamine. Henry Ford Hosp Med Bull 10:287-296, 1962 MedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: ALLAN L. GOLDMAN, M.D.; DEMETRIOS G. HALKIAS, PH.D.Affiliations: PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 August 1975Volume 83, Issue 2Page: 283-283KeywordsSpecificity ePublished: 1 December 2008 Issue Published: 1 August 1975 PDF downloadLoading ...
On the Absorption of Certain Salts from the Alimentary Canal
Authors: M. Hay
Journal: BMJ (1882)

How the splitting-up of the sulphates in the intestines is effected, and in what combination the acid passes into the blood, is beyond the scope of the present communication.VACCINATION.-Mr.T. II.Hughes, Public Vaccinator of the Ombersley district of the Droitwich Union, has received (for the fourth time) the Government grant for efficient vaccination in his district.
Mycophenolate Mofetil Decreases Atherosclerotic Lesion Size by Depression of Aortic T-Lymphocyte and Interleukin-17–Mediated Macrophage Accumulation
Authors: Sibylle von Vietinghoff, Ekaterina K. Koltsova, Javier Mestas, Cody J. Diehl, Joseph L. Witztum, Klaus Ley
Journal: Journal of the American College of Cardiology (2011)
The blood service should ask donors about practice, not just partners
Authors: M. Sothern, M. Kesby
Journal: BMJ (2011)

ROB WHITE

Richard Titmuss’s seminal study of blood donation systems, The Gift Relationship , concludes that the central question for ensuring the safety of the blood supply is, “What particular set of conditions and arrangements permits and encourages maximum truthfulness on the part of donors?” (see BMJ 2011;342:d2078, doi:10.1136/bmj.d2078).

Notwithstanding advances in the epidemiological modelling of risk and the screening of blood, truth telling and trust remain pivotal. Screening is imperfect, and laboratory facilities are overstretched. So the UK National Blood Service uses a “donor health check” questionnaire to identify would-be donors whose “lifestyle and medical history” puts them at greater risk of having contracted a transfusion transmittable viral infection (www.blood.co.uk/can-i-give-blood/donor-health-check). This triage of potential donors is designed to limit the volume of infected blood entering this fallible system.

Donors are trusted to answer a range of questions, including whether they have recently had a tattoo, travelled from a region of high HIV prevalence, or had sex with someone known to have HIV. They are also asked, “Are you a man who has ever had oral or anal sex, whether or not a condom was used, with another man [hereafter MSM]?” Answering “yes” to these questions currently results in a six month, 12 month, or lifetime deferral.

Permanent deferral of MSM is controversial, and the government has just announced a change …
Adding fuel to fire: microRNAs as a new class of mediators of inflammation
Authors: F J Sheedy, L A J O'Neill
Journal: Annals of the Rheumatic Diseases (2008)

MicroRNAs (miRNAs) are recently discovered regulators of gene expression, and early studies have indicated that they have a role in the regulation of haematopoiesis, the immune response and inflammation. They bind the 3'UTR of target mRNAs and mainly prevent translation of the protein product. Dysregulation of these molecules has been shown to be a hallmark of cancer and now investigators are examining their role in the pathogenesis of inflammatory diseases. miR-146 and miR-155 have been a particular focus for investigators, and these two miRNAs have been shown to be induced by proinflammatory stimuli such as interleukin 1, tumour necrosis factor α (TNFα) and Toll-like receptors (TLRs). They have also been detected in synovial fibroblasts and rheumatoid synovial tissue. Both have multiple targets, with miR-146 inhibiting TLR signalling and miR-155 regulating Th1 cells and also, interestingly, positively regulating mRNA for TNFα. The potential of miRNAs for improving our understanding of the pathogenesis of diseases such as rheumatoid arthritis, and for developing potentially new treatments for these diseases, is substantial.
Reply to Oliver W. Hakenberg and Chris Protzel’s Letter to the Editor re: Niels M. Graafland, Joost A.P. Leijte, Renato A. Valdés Olmos, et al. Scanning with 18F-FDG-PET/CT for Detection of Pelvic Nodal Involvement in Inguinal Node-Positive Penile Carcinoma. Eur Urol 2009;56:339–45
Authors: Niels M. Graafland, Simon Horenblas
Journal: European Urology (2009)