AMYOTROPHIC LATERAL SCLEROSIS ON GUAM: A CLINICAL STUDY AND REVIEW OF THE LITERATURE
Authors: D R KOERNER
Journal: Annals of Internal Medicine (1952)

Article1 December 1952AMYOTROPHIC LATERAL SCLEROSIS ON GUAM: A CLINICAL STUDY AND REVIEW OF THE LITERATUREDONALD R. KOERNER, M.D.DONALD R. KOERNER, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-37-6-1204 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe purpose of this article is to report the unusual occurrence of an uncommon syndrome found in the native population of Guam. At the same time the American literature of the past 20 years has been reviewed to determine whether any notable differences could be demonstrated between the condition as found on Guam and as described in the literature.Guam is an island of the Micronesian group, located about 13° above the equator in a climate where the temperature averages consistently about 85° F., and whose yearly rainfall averages about 80 inches. It is peopled by Chamorros whose original ancestry...Bibliography1. GrinkerBucy RRPC: Neurology, 4th Ed., 1949, C. Thomas, Springfield, Ill. Google Scholar2. Nielson JM: A textbook of clinical neurology, 2nd Ed., 1947, Harper and Bros., New York and London. Google Scholar3. BingHaymaker RW: Textbook of nervous diseases, 5th Ed., 1939, C. V. Mosby Co., St. Louis. Google Scholar4. WilsonBruce SAAN: Neurology, The Williams and Wilkins Co., Baltimore. Google Scholar5. Wechsler IS: A textbook of clinical neurology, 5th Ed., 1943, W. B. Saunders Co., Philadelphia and London. Google Scholar6. JelliffeWhite SEWA: Diseases of the nervous system, 5th Ed., 1935, Lea and Febiger, Philadelphia. Google Scholar7. Walshe FM: Diseases of the nervous systems, 2nd Ed., 1942, The Williams and Wilkins Co., Baltimore. Google Scholar8. Alpers BJ: Clinical neurology. 1946, F. A. Davis, Philadelphia. Google Scholar9. Helfand M: Progressive bulbar paralysis; the pathology and relation to amyotrophic lateral sclerosis, J. Nerv. and Ment. Dis. 78: 362, 1933. CrossrefGoogle Scholar10. SwankPutnam RLTJ: Amyotrophic lateral sclerosis and related conditions; a clinical analysis, Arch. Neurol. and Psychiat. 49: 151, 1943. CrossrefGoogle Scholar11. FriedmanFreedman APD: Amyotrophic lateral sclerosis, J. Nerv. and Ment. Dis. 111: 1, 1950. CrossrefMedlineGoogle Scholar12. WechslerSapirsteinStein ISMRA: Primary and symptomatic amyotrophic lateral sclerosis; a clinical study of 81 cases, Am. J. M. Sc. 208: 70, 1944. CrossrefGoogle Scholar13. Pritchard EA: Amyotrophic lateral sclerosis of unusual distribution, Proc. Roy. Soc. Med. 27: 670, 1934. CrossrefGoogle Scholar14. Ziegler LH: Psychotic and emotional phenomena associated with amyotrophic lateral sclerosis, Arch. Neurol. and Psychiat. 24: 930, 1930. CrossrefGoogle Scholar15. Reed AC: Nervous diseases in China, Boston M. and S. J. 171: 638, 1914. CrossrefGoogle Scholar16. Veit H: Dynamic view of amyotrophic lateral sclerosis, J. Nerv. and Ment. Dis. 106: 129, 1947. CrossrefMedlineGoogle Scholar17. Ask-Upmark E: Amyotrophic lateral sclerosis observed in five persons after gastric resection, Gastroenterology 15: 257, 1950. CrossrefMedlineGoogle Scholar18. Jelliffe SE: Amyotrophic lateral sclerosis syndrome and trauma, J. Nerv. and Ment. Dis. 82: 415, 1935. CrossrefGoogle Scholar19. AlpersFarmer BJRA: Role of repeated trauma by pneumatic drill in production of amyotrophic lateral sclerosis, Arch. Neurol. and Psychiat. 62: 178, 1949. CrossrefMedlineGoogle Scholar20. WaggonerLöwenberg RWK: Role of trauma in amyotrophic lateral sclerosis, Arch. Neurol. and Psychiat. 45: 296, 1941. CrossrefGoogle Scholar21. Ornsteen AM: The syndrome of amyotrophic lateral sclerosis in epidemic encephalitis, J. Nerv. and Ment. Dis. 72: 369, 1930. CrossrefGoogle Scholar22. BarnardFriedland RDS: The atopic nature of amyotrophic lateral sclerosis; evidence afforded by results with adrenal cortex therapy, New York State J. Med. 50: 1365, 1950. MedlineGoogle Scholar23. McCullaghHewlett EPJS: Acromegaly associated with amyotrophic lateral sclerosis and acromegaly of the amyotrophic type, J. Clin. Endocrinol. 7: 636, 1947. CrossrefGoogle Scholar24. Young RH: Syndrome of amyotrophic lateral sclerosis of bulbar type associated with platybasia, J. Nerv. and Ment. Dis. 97: 133, 1943. CrossrefGoogle Scholar25. Kayne GG: Retrosternal goitre and amyotrophic lateral sclerosis, Proc. Roy. Soc. Med. 26: 524, 1933. CrossrefMedlineGoogle Scholar26. SwankPrice RLJC: Fascicular muscle twitchings in amyotrophic lateral sclerosis; their origin, Arch. Neurol. and Psychiat. 49: 22, 1943. CrossrefGoogle Scholar27. SheldenWoltman CHHW: Origin of fibrillary twitchings, Proc. Staff Meet., Mayo Clin. 15: 646, 1940. Google Scholar28. Davison C: Amyotrophic lateral sclerosis. Origin and extent of the upper motor neuron lesion, Arch. Neurol. and Psychiat. 46: 1039, 1941. CrossrefGoogle Scholar29. DavisonWechsler CIS: Amyotrophic lateral sclerosis with involvement of posterior column and sensory disturbances, clinicopathological study, Arch. Neurol. and Psychiat. 35: 229, 1936. CrossrefGoogle Scholar30. WohlfartSwank SRL: Pathology of amyotrophic lateral sclerosis. Fiber analysis of the ventral roots and pyramidal tracts of the spinal cord, Arch. Neurol. and Psychiat. 46: 783, 1941. CrossrefGoogle Scholar31. Hassin GB: Amyotrophic lateral sclerosis. Anatomic and pathologic considerations, Arch. Neurol. and Psychiat. 43: 765, 1940. CrossrefGoogle Scholar32. Hassin GB: Amyotrophic lateral sclerosis, complicated by sub-acute combined degeneration of the cord; clinical and pathological report of a case, Arch. Neurol. and Psychiat. 29: 125, 1933. CrossrefGoogle Scholar33. FriedlanderKesert JWBH: The role of psychosis in amyotrophic lateral sclerosis, J. Nerv. and Ment. Dis. 107: 243, 1948. CrossrefMedlineGoogle Scholar34. WechslerDavison ISC: Amyotrophic lateral sclerosis with mental symptoms; a clinicopathological study, Arch. Neurol. and Psychiat. 27: 859, 1932. CrossrefGoogle Scholar35. Androp S: Amyotrophic lateral sclerosis with psychosis, Psychiatric Quart. 14: 818, 1940. CrossrefGoogle Scholar36. Meiler C: Amyotrophic lateral sclerosis with psychosis, paranoid type, Minnesota Med. 23: 858, 1940. Google Scholar37. Lingenfelder JL: Personal communication. Google Scholar38. Wechsler IS: Recovery in amyotrophic lateral sclerosis treated with tocopherols (vitamin E), preliminary report, J. A. M. A. 114: 948, 1940. Google Scholar39. Rosenberger AI: Observations on the treatment of amyotrophic lateral sclerosis with vitamin E, M. Rec. 154: 97, 1941. Google Scholar40. Bicknell F: Vitamin E in the treatment of muscular dystrophies and nervous diseases, Lancet 1: 10, 1940. CrossrefGoogle Scholar41. Davison C: Effect of vitamin E therapy on the central nervous system in amyotrophic lateral sclerosis, Bull. New York Acad. Med. 19: 386, 1943. MedlineGoogle Scholar42. WeinbergKnoll MHAF: Beneficial effect of vitamin E on amyotrophic lateral sclerosis, M. Rec. 152: 447, 1940. Google Scholar43. WeberClinco JJAA: Report of a case of amyotrophic lateral sclerosis treated with vitamin E, M. Times, New York 70: 247, 1942. Google Scholar44. Lubin AJ: Use of alpha tocopherol in treatment of neuromuscular disorders, Arch. Int. Med. 69: 836, 1942. CrossrefGoogle Scholar45. Merwarth HR: Synthetic vitamin E in the treatment of amyotrophic lateral sclerosis and related disorders, Dis. Nerv. System 2: 325, 1941. Google Scholar46. EatonWoltmanButt LMHWHR: Vitamins E and B6 in the treatment of neuromuscular disease, Proc. Staff Meet., Mayo Clin. 16: 523, 1941. Google Scholar47. DeJong RN: Vitamin E and alpha tocopherol therapy of neuromuscular and muscular disorders, Arch. Neurol. and Psychiat. 46: 1068, 1941. CrossrefGoogle Scholar48. DenkerScheinman PGL: Treatment of amyotrophic lateral sclerosis with vitamin E (alpha tocopherol), J. A. M. A. 116: 1893, 1941. CrossrefGoogle Scholar49. FerrebeeKlingmanFrantz JWWOAM: Vitamin E and vitamin B6 in the treatment of muscular dystrophy and amyotrophic lateral sclerosis, clinical experience, J. A. M. A. 116: 1895, 1941. CrossrefGoogle Scholar50. DoyleMerritt AMHH: Vitamin therapy of diseases of the neuromuscular apparatus, Arch. Neurol. and Psychiat. 45: 672, 1941. CrossrefGoogle Scholar51. SchwarzGammonMasland GAGDRL: Use of d-1 alpha tocopherol acetate (synthetic vitamin E) in various neuromuscular disturbances, J. Nerv. and Ment. Dis. 96: 286, 1942. CrossrefGoogle Scholar52. ZechTelford VLIR: Negative effect of massive doses of vitamin E on amyotrophic lateral sclerosis, Arch. Neurol. and Psychiat. 50: 190, 1943. CrossrefGoogle Scholar53. Aird RB: Trypan red therapy of amyotrophic lateral sclerosis, preliminary report, Arch. Neurol. and Psychiat. 59: 779, 1948. CrossrefMedlineGoogle Scholar54. Barnard RD: Rectal administration of tolserol: the therapeutic efficiency of this route as demonstrated in amyotrophic lateral sclerosis, New York State J. Med. 49: 2190, 1949 MedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Rochester, N. Y.*Received for publication May 7, 1952.†Jose M. Torres was a member of the first graduating class of the School for Medical Assistants, conducted by the U. S. Navy for training in the medical sciences of natives from several Pacific islands, including American Samoa and the Marshall, Caroline and Marianas groups. J. Torres was the first to serve in the capacity of intern at the Guam Memorial Hospital. 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Systematic Analysis of Metals on Guamanian ALS and PD CasesSOME LIGHT ON VITAMIN DNEUROPATHOLOGICAL NORMALITY IN GUAMAMYOTROPHIC LATERAL SCLEROSIS IN FINLANDAMYOTROPHIC LATERAL SCLEROSIS IN FINLANDREFERENCESThe epidemiology of amyotrophic lateral sclerosis in FinlandNeutron Activation Analysis of Calcium in Central Nervous System Tissue of Amyotrophic Lateral Sclerosis CasesAmyotrophic lateral sclerosisTHE PATHOGENESIS OF AMYOTROPHIC LATERAL SCLEROSISHereditary amyotrophic lateral sclerosisPROGNOSIS OF AMYOTROPHIC LATERAL SCLEROSISEpidemiological study of amyotrophic lateral sclerosis and allied disorders in the Kii peninsula (Japan)Motor neuron diseaseABO BLOOD-GROUPS IN MOTOR-NEURONE DISEASEA forma pseudomiopática tardia da atrofia muscular progressiva heredo-familialMotor Neurone DiseaseGenetic aspects of amyotrophic lateral sclerosis and progressive bulbar paralysisDescriptive epidemiology of selected neurologic and myopathic disorders with particular reference to a survey in Rochester, MinnesotaDie myatrophische LateralsklerosePregnancy Complicated by Amyotrophic Lateral SclerosisMultiple Sclerosis and Amyotrophic Lateral Sclerosis 1 December 1952Volume 37, Issue 6Page: 1204-1220KeywordsAmyotrophic lateral sclerosisTemperature ePublished: 1 December 2008 Issue Published: 1 December 1952 PDF downloadLoading ...