tbuckley/cabot-search huggingface dataset:
Functional Results of Gastric Interposition Following Total Esophagectomy
Authors: ALAN G. CASSON, JOHN POWE, RICHARD INCULET, RICHARD FINLEY
Journal: Clinical Nuclear Medicine (1991)

Functional results of gastric interposition were evaluated in 35 patients at 3 to 84 months following esophagectomy. All patients were satisfied with the results of surgery, although 14 (40%) still experienced some degree of dysphagia. Transit times for radiolabeled solids across the cervical esophagus and anastomosis were not significantly different for the 14 symptomatic patients (mean 77 seconds) versus 21 asymptomatic patients (mean 55 seconds). Spontaneous emptying of the vagotomized intrathoracic stomach appeared complex, with mean percentage radionuclide clearances at 30 minutes (semisolid meal) calculated at 37% for 23 patients with early satiety (versus 42% asymptomatic) and at 38% for nine patients with reflux (versus 39% asymptomatic), all values comparable to emptying of the normal intra-abdominal stomach (35% clearance at 30 minutes). Our data suggest that the interposed stomach appears to retain its gastric identity rather than act as an inert conduit, and that although little correlation exists between postoperative symptoms and objective findings, the stomach remains a satisfactory esophageal substitute.
Neutrophil and monocyte CD64 indexes, lipopolysaccharide-binding protein, procalcitonin and C-reactive protein in sepsis of critically ill neonates and children
Authors: Mojca Groselj-Grenc, Alojz Ihan, Maja Pavcnik-Arnol, Andreja Natasa Kopitar, Tanja Gmeiner-Stopar, Metka Derganc
Journal: Intensive Care Medicine (2009)
Targeting the p27 E3 ligase SCFSkp2 results in p27- and Skp2-mediated cell-cycle arrest and activation of autophagy
Authors: Qing Chen, Weilin Xie, Deborah J. Kuhn, Peter M. Voorhees, Antonia Lopez-Girona, Derek Mendy, Laura G. Corral, Veronique Plantevin Krenitsky, Weiming Xu, Laure Moutouh-de Parseval, David R. Webb, Frank Mercurio, Keiichi I. Nakayama, Keiko Nakayama, Robert Z. Orlowski
Journal: Blood (2008)
The Transcription Factor PU.1 Controls Dendritic Cell Development and Flt3 Cytokine Receptor Expression in a Dose-Dependent Manner
Authors: Sebastian Carotta, Aleksandar Dakic, Angela D'Amico, Swee Heng Milon Pang, Kylie T. Greig, Stephen L. Nutt, Li Wu
Journal: Immunity (2010)
CONGENITAL HEART BLOCK
Authors: J. Murray Kinsman
Journal: JAMA (1935)

About fifty cases of congenital heart block have been reported in the literature. Several authors have collected and analyzed the reported cases. There is some difference of opinion concerning the correctness of the diagnosis in a few of them, as in some there was no graphic proof that heart block actually existed and in others there was considerable doubt that it was congenital and not acquired. The heart rate of an infant is normally very rapid, and in the presence of a partial block or even of a complete block the rate, though relatively slow in comparison with the normal for the age, may still be faster than the normal rate for adults. Hence the presence of an interference with conduction may easily be overlooked. Until recently, when medical men began to become aware of its possibility, it was rare that any abnormality of this nature was discovered within the first few weeks or months of life, and sometimes years elapsed before the condition was recognized. When there is no record of the heart
Apparatus and Routine for Diabetic Ward-tests
Authors: T. C. Beard
Journal: BMJ (1946)

Most authorities who believe that a high blood sugar (even in the absence of ketosis) is harmful to the diabetic ask for a multitude of tests, which, in a hospital devoid of  studenitlabour, are apt to encroach severely on the nurses' and housephvsician's time. The following routine was adopted at this hospital from the method in use at St. Bartholomew's and has led to great economy of effort. The method of three-hourly tests is that advocated by Dr. George Graham, and the chart is a modification of his. I am indebted to him for his advice and permission to submit these details for publication.
Clinical Trial of Oxymorphone in Labour
Authors: G. M. Eames, K. R. S. Pool
Journal: BMJ (1964)

The results of 166 assays of urinary gonadotrophins in women with carcinoma of the breast are described.There was a significantly lower excretion of gonadotrophins in women who were unresponsive to hormonal therapy and in " poor " clinical condition.The significance of these findings is briefly discussed.The technical assistance of Miss Pamela Wilson and the help of Sister T. E. Williams, of the Cancer Follow-up Clinic, in super- vising the urine collections are gratefully acknowledged, as is the advice of Dr.
THE ACTION OF PASTES
Authors: G. H. PERCIVAL
Journal: British Journal of Dermatology (1929)

Journal Article THE ACTION OF PASTES Get access G. H. PERCIVAL, M.B., PH.D G. H. PERCIVAL, M.B., PH.D Pharmacology Department, University of Edinburgh Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology and Syphilis, Volume 41, Issue 6, 1 June 1929, Pages 231–235, https://doi.org/10.1111/j.1365-2133.1929.tb09345.x Published: 01 June 1929
Six-Month Clinical and Angiographic Outcome of the New, Less Shortening Wallstent in Native Coronary Arteries
Authors: Yukio Ozaki, David Keane, Peter Ruygrok, Willem J. van der Giessen, Pim de Feyter, Patrick W. Serruys
Journal: Circulation (1996)

Background The new, less shortening, self-expanding Wallstent is characterized by longitudinal flexibility, a protective membrane, a low profile, and a customized range of diameters (3.5 to 6.0 mm). The recent modification of the braiding angle of the Wallstent has resulted in a new device with less shortening on expansion and a concomitant reduction in radial force. We hypothesized that the enforced mechanical remodeling produced by the selection of an oversized Wallstent might result in improved accommodation of subsequent reactive intimal hyperplasia and prevention of chronic recoil of the vessel. Methods and Results To prove this hypothesis, we recently implanted 44 new, less shortening Wallstents in 35 native coronary arteries in 35 patients with acute or threatened closure after balloon angioplasty, according to a strategy of oversizing of Wallstent diameter and complete coverage of the lesion length. The initial and 6-month follow-up angiograms were analyzed with a computer-based quantitative coronary angiography (QCA) system. Acute gain (minimal luminal diameter [MLD] post minus MLD pre) and late loss (MLD post minus MLD at follow-up) were examined. Stent deployment was successful in 44 of 44 attempts (100%). Nominal stent diameter used was 1.40 mm larger than the maximal vessel diameter. One patient (3%) with a dilated but unstented lesion proximal to the stented segment sustained a subacute occlusion on day 1 associated with myocardial infarction. Event-free survival at 30 days after stent implantation was 97% (34 of 35 patients). Of the 34 patients eligible for 6-month angiographic follow-up, 3 who were asymptomatic declined repeat angiography. MLD (and percent diameter stenosis [% DS]) changed from 0.83±0.50 mm (72%) pre through 3.06±0.48 mm (15%) post to 2.27±0.74 mm (28%) at follow-up. Acute gain was 2.23±0.63 mm, and late loss was 0.78±0.61 mm. Angiographic restenosis (&gt;50% DS) was observed in 5 of 31 patients (16%) at 6 months, all of whom underwent repeat angioplasty. Thus, the overall event-free survival at 6-month follow-up was 83% (29 of 35 patients). Conclusions The oversized Wallstent implantation with complete coverage of the lesion length conveyed a favorable 6-month clinical and angiographic outcome. The large acute gain obtained by the Wallstent afforded greater accommodation of the subsequent late loss. The enforced mechanical remodeling by oversized new Wallstents may result in prevention of acute and chronic recoil of the vessel wall and subsequently a lower restenosis rate at follow-up.
Interpretation based on richness of experience: Theory development from a social-constructivist perspective
Authors: Arlene S. Walker-Andrews, Judith A. Hudson
Journal: Behavioral and Brain Sciences (2004)

The view that children's understanding of mind is constructed through social interaction is consistent with other social-constructivist models. We provide examples of similar claims in research on emotion perception, pretense understanding, autobiographical memory, and event knowledge. Identification of common elements from such socio-cultural perspectives may lead to greater theoretical integration and provide a new framework for exploring human development.
Muehrcke's Lines
Authors: Maya Morrison-Bryant, Jeremy D Gradon
Journal: New England Journal of Medicine (2007)

A 46-year-old woman with metastatic sarcoma who had been treated with five cycles of doxorubicin, ifosfamide, and mesna chemotherapy presented with two symmetrical, horizontal white lines on all of her fingernails but not on her toenails. A diagnosis of Muehrcke's lines was made. Muehrcke's lines are the two smooth white bands that run parallel to the lunula across the width of the nail. The lines are nonpalpable and, unlike Beau's lines, do not indent the nail itself. Normal-appearing pink nail-bed tissue is seen between the two white lines, and thumb involvement is rare. Muehrcke's lines are a nonspecific finding that . . .
Peter Ambrose Gardiner
Authors: G. Catford
Journal: BMJ (2002)

Ophthalmologist who developed a vision test for children and who wrote frankly about his lifestyle

Peter Gardiner once wrote that his lifestyle so disgusted the medical establishment and increased managers' costs that he was on a hit list. In a frank and unrepentant anecdotal report published in the BMJ just after his 81st birthday he encouraged “all those who are worried by their lifestyle not to despair” (BMJ 1994;309:1709-10). “My diet has always included generous amounts of meat, butter, eggs, fried foods, chips, cheese,” he wrote. “I have always drunk plenty of alcohol,” he added. But perhaps his trademark was the cigarette and holder. He described himself as “for 60 years a heavy smoker of cigarettes—for 50 years always with a holder. The amount of tar on the cleaner has shown what my lungs have been spared.”


After school at Westminster and medical training at Guy's Hospital, Peter specialised in ophthalmology, proceeding to an MD in London with research into myopia in 1960. During the second world war he served in the Royal Air Force and was posted to Iceland as a squadron leader. 




Back in civilian life he was appointed ophthalmic surgeon at Barnet General Hospital and research ophthalmologist at Guy's, where he evolved the Guy's colour vision test and later became consultant emeritus in ophthalmology.

For many years he was a chief clinical assistant at Moorfields Eye Hospital in High Holborn, but his favourite work was caring for disabled children as ophthalmologist to the now defunct Inner London Education Authority. He co-founded the eye group of the Spastics Society (now Scope) with Ronnie MacKeith and Mary Sheridan, and will be remembered in conjunction with the latter for the universally used Sheridan-Gardiner test for young children.

Peter produced the first edition of the BMJ 's first ABC book, the ABC of Ophthalmology, which was translated into several languages.

He retired to Woodbridge in Suffolk in 1978, where he kept up a great practical interest in gardening until his last year.

Predeceased by his wife, Bridget, he leaves three children and four grandchildren.

Peter Ambrose Gardiner, consultant emeritus in ophthalmology Guy's Hospital, London, and former consultant Barnet General Hospital and to the Inner London Education Authority; b 1913; q Guy's Hospital 1937; DOMS, MD; died from heart failure and old age on 4 February 2002.
Hospital peer review: a new proposal
Authors: B. H. Epstein
Journal: JAMA (1994)

<h3>To the Editor.</h3> —For many years the basis of hospital peer review has been internally driven by physicians and nurses reviewing one another. This has been accomplished by volunteer physicians through hospital committees at no cost to the institution. To our knowledge, the real cost in terms of person-hours has never been calculated, but it has never been a concern because of willing volunteerism. As public confidence in our ability to review ourselves has eroded, the concept of "external" peer review has developed. This has the obvious advantage of reviewers' not being personally involved with the "reviewees," but also has the major disadvantage of cost. We must consider that as physicians' incomes decrease with health system reform and as demands on our time increase, the willingness of physicians to volunteer this service may diminish. At some point, reviewers both internally and externally may demand payment for services rendered. Nevertheless, up
THE DIET DURING INSULIN TREATMENT OF DIABETES MELLITUS: THE NEED FOR CAREFUL CONTROL
Authors: K. S. Hetzel
Journal: BMJ (1924)

230 EIMD_CAL JOUA reaclhed a considerable degree of dilatation, if not fully dilated.The impacted head produces severe pressure effects uponl the soft tissues of the cervix, or vaginal fornices, and the parametric tissue between the head and the bony pelvis.If this pressure is allowed to persist for long the vitality of the tissues is reduced, and they may subsequently undergo necrosis while the risk of infection is increased.All these influences of contracted pelvis on labour are the result of actual disproportion of the head to the pelvis; they arise indirectly frolmi the contraction but directly from the obstruction.Variations of the vertex presentation result from delay in the head entering the brim after it has come against the bony wall.Moulding begins when the head has engaged in the brim but is too large to pass.Mechanism depends upon the ability of the head to move so as to adapt its diameters to the available space; it follows the ordinary laws of mechanics, and when these fail to enable the head to pass jamming occurs.Further advance depends upon crushing of the head through the niarrow parts; if this fails impaction results, and the effects of .impactionprogressively advance even though secondary uterine inertia sets in and persists.Alterations of the vertex and moulding and arrest of the head do no harm of themselves, but it is essential to under- stand their import, as they indicate obstruction, and when that persists serious effects are produced on the mother and inifant.
Augmentation of reverse arthus reaction by mast cells in mice.
Authors: Y Zhang, B F Ramos, B A Jakschik
Journal: Journal of Clinical Investigation (1991)

Immune complex-induced injury is an important pathogenic factor in antibody-mediated nephritis, systemic lupus erythematosus, rheumatoid arthritis, and other diseases. In this study we investigated the role mast cells in immune complex-mediated injury in mouse skin. Reverse Arthus reaction was induced in mast cell-deficient WBB6F1-W/Wv mice and their congenic controls (WBB6F1(-)+/+). Serial skin sections were evaluated for neutrophil infiltration, edema, and hemorrhage. In WBB6F1-W/Wv mice the neutrophil influx was only 40% and edema 60% of that in congenic controls. Hemorrhage was also significantly reduced in the mast cell-deficient mice. After mast cell reconstitution, the magnitude of the reaction in WBB6F1-W/Wv was equivalent to that in WBB6F1(-)+/+ mice. Mast cell release in reverse Arthus reaction was evaluated by measuring fluorescence intensity after avidin-FITC staining of mast cell granules. There was a 70% decrease in fluorescence intensity. The 5-lipoxygenase inhibitor A-63162 significantly decreased neutrophil accumulation (40%), edema (60%), and hemorrhage in WBB6F1(-)+/+, but not in mast cell-deficient mice. Mast cell reconstitution of WBB6F1-W/Wv mice restored the effect of A-63162. The results indicate that mast cells and their mediators, including leukotrienes, make an important contribution to reverse Arthus reaction.
The application of radionuclide infarct scintigraphy to diagnose perioperative myocardial infarction following revascularization.
Authors: S C Klausner, E H Botvinick, D Shames, D J Ullyot, N H Fishman, B B Roe, P A Ebert, K Chatterjee, W W Parmley
Journal: Circulation (1977)

To evaluate the application of radionuclide infarct scintigraphy to diagnose myocardial infarction after revascularization, we obtained postoperative technetium 99m pyrophosphate myocardial scintigrams, serial electrocardiograms and CPK-MB isoenzymes in ten control and 51 revascularized patients. All control patients had negative electrocardiograms and scintigrams, but eight had positive isoenzymes. Eight revascularized patients had positive electrocardiograms, images and enzymes and two had positive scintigrams and enzymes with negative electrocardiograms. Thirty-four patients with negative electorcardiograms and scintigrams had positive isoenzymes; in only seven patients were all tests negative. Our data suggest radionuclide infarct scintigraphy is a useful adjunct to the electrocardiogram in diagnosing perioperative infarction. The frequent presence of CPK-MB in postoperative patients without other evidence of infarction suggests that further studies are required to identify all factors responsible for its release.
A novel rapid-onset high-penetrance plasmacytoma mouse model driven by deregulation of cMYC cooperating with KRAS12V in BALB/c mice
Authors: Y Hu, M Zheng, R Gali, Z Tian, G Topal Görgün, N C Munshi, C S Mitsiades, K C Anderson
Journal: Blood Cancer Journal (2013)

Our goal is to develop a rapid and scalable system for functionally evaluating deregulated genes in multiple myeloma (MM). Here, we forcibly expressed human cMYC and KRAS12V in mouse T2 B cells (IgM(+)B220(+)CD38(+)IgD(+)) using retroviral transduction and transplanted these cells into lethally irradiated recipient mice. Recipients developed plasmacytomas with short onset (70 days) and high penetrance, whereas neither cMYC nor KRAS12V alone induced disease in recipient mice. Tumor cell morphology and cell surface biomarkers (CD138(+)B220(-)IgM(-)GFP(+)) indicate a plasma cell neoplasm. Gene set enrichment analysis further confirms that the tumor cells have a plasma cell gene expression signature. Plasmacytoma cells infiltrated multiple loci in the bone marrow, spleen and liver; secreted immunoglobulins; and caused glomerular damage. Our findings therefore demonstrate that deregulated expression of cMYC with KRAS12V in T2 B cells rapidly generates a plasma cell disease in mice, suggesting utility of this model both to elucidate molecular pathogenesis and to validate novel targeted therapies.
Prospective study of formalin-fixed Mohs surgery and haematoxylin and eosin stains with control contralateral biopsies for lentigo maligna: 5-year follow-up results
Authors: C.M. Lawrence, R. Rahim, F. Charlton, A. Husain
Journal: British Journal of Dermatology (2014)

There is little consensus on the optimum form of surgical management for lentigo maligna (LM). Currently, because malignant melanocytes spread down adnexal structures, full-thickness skin removal is the only surgical option. Interpretation of Mohs histological specimens is difficult because of the presence of abnormal melanocytes in otherwise normal sun-damaged skin.To investigate Slow Mohs for surgical excision of LM, to see whether the use of control contralateral skin biopsies would enable the end point of excision to be more easily interpreted and to investigate factors that influence the subclinical amelanotic extensions of LM.The Slow Mohs technique for formalin-fixed tissue was used in 74 patients with LM. Before surgery LMs were classified as well defined, poorly defined, incompletely excised or recurrent. Control biopsies were taken from healthy skin of the contralateral side. Specimens were processed in formalin, stained with haematoxylin and eosin (H&E) and the results read at 24-48 h. The excision margin required for complete excision was measured and patients were followed for a minimum of 5 years to exclude recurrence.On average the final excision margin required was 6·7 mm. Margins were significantly greater for ill-defined, recurrent and incompletely excised LM compared with well-defined LM. The presence of depigmented patches preoperatively did not correlate with the excision margin, but LMs showing nesting required significantly wider excision margins. There were seven (12%) recurrences at a mean 4·4 years after surgery in the group with 5-year follow-up. Recurrence occurred only in recurrent and ill-defined primary LM.The use of Slow Mohs formalin-fixed tissue and H&E section staining, even with comparator biopsies, does not provide sufficient discrimination to identify residual disease confidently.
The Principles of Transurethral Resection and Haemostasis
Authors: Joseph H. Kiefer
Journal: JAMA (1973)

This volume indicates that transurethral resection, developed about 40 years ago in the United States and widely used in the Americas, has now been accepted in the British Isles, at least by some urologists, as a fullfledged procedure in the urological armamentarium, with full status and equality with open surgery. The book is a thorough discussion of the indications, preoperative selection, preparation, instruments, technique and postoperative care as seen in the light of the author's experience and preferences. As stated in the very title, and repeated and emphasized throughout the book, the author holds a major premise that good transurethral surgery is not possible without good hemostasis. In addition to a technique directed towards this end, he enthusiastically advocates the use of hypotensive anesthesia. Transurethral resection for benign hyperplasia of the prostate should be restricted to cases in which the estimated weight of tissue to be removed is 25 to
Efficient cell surface expression of class II MHC molecules in the absence of associated invariant chain.
Authors: J Miller, R N Germain
Journal: The Journal of Experimental Medicine (1986)

The intracytoplasmic forms of class II (or Ia) major histocompatibility complex heterodimers are associated with a third glycoprotein, termed the invariant chain (Ii). This specific interaction has led to the view that Ii plays a necessary role in the assembly, intracellular transport, and/or membrane insertion of Ia molecules. To test this hypothesis directly, we have transfected complementary DNA clones that encode murine class II alpha and beta chains into cells that do not express any endogenous Ii messenger RNA (mRNA) (COS-7 and BALB/c 3T3 cells). After DNA-mediated gene transfer, significant cell surface expression of Ia was observed in transient expression assays using COS-7 cells and a stable expression system using BALB/c 3T3 cells. Furthermore, the total levels of class II alpha and beta mRNA were similar in Ii- cells (transfected BALB/c 3T3) and in Ii+ cells (B cell hybridoma) that expressed nearly identical amounts of surface Ia, suggesting that the efficiency of Ia expression was equivalent in the two cell types and, therefore, independent of Ii. These results indicate that the physiologic role for Ii is not simply to mediate membrane expression of Ia molecules, and that alternative hypotheses concerning the true function of this molecule need to be considered.
Translocation t(2;11) in CLL cells results in CXCR4/MAML2 fusion oncogene
Authors: Mario Acunzo, Giulia Romano, Dorothee Wernicke, Veronica Balatti, Laura Z. Rassenti, Marie dell’Aquila, Thomas J. Kipps, Yuri Pekarsky, Carlo M. Croce
Journal: Blood (2014)