tbuckley/cabot-search huggingface dataset:
Überblick über den 8. Internationalen Kongress fur Psychotherapie
Authors: H.K. Fierz
Journal: Psychotherapy and Psychosomatics (1972)

A lively discussion took place at the 8th International Congress of Psychotherapy over means by which psychotherapy could better fulfil its role in society. At times, too much was couched in 'scientific' terms, with overtones from the fields of philosophy and sociology. Not only that, but there was a tendencey here and there to confuse the endeavour towards progress with the fight for power. But, by and large, the discussions were fruitful and stimulating.
Differential effects of beta-blockade on dispersion of repolarization in the absence and presence of sympathetic stimulation between the lqt1 and lqt2 forms of congenital long qt syndrome
Authors: Wataru Shimizu, Yasuko Tanabe, Takeshi Aiba, Masashi Inagaki, Takashi Kurita, Kazuhiro Suyama, Noritoshi Nagaya, Atsushi Taguchi, Naohiko Aihara, Kenji Sunagawa, Kazufumi Nakamura, Tohru Ohe, Jeffrey A Towbin, Silvia G Priori, Shiro Kamakura
Journal: Journal of the American College of Cardiology (2002)
Genetic elements used for a murine lupus anti-DNA autoantibody are closely related to those for antibodies to exogenous antigens.
Authors: R Kofler, D J Noonan, D E Levy, M C Wilson, N P Møller, F J Dixon, A N Theofilopoulos
Journal: The Journal of Experimental Medicine (1985)

The mRNAs encoding heavy and light chains of a hybridoma-derived monoclonal IgM kappa anti-DNA autoantibody from lupus-prone MRL/Mp-lpr/lpr mice (Ighj) have been transcribed into cDNA copies and molecularly cloned, and their complete nucleotide sequences have been determined. The mRNA for the heavy chain variable region, including leader peptide and 5' untranslated region, is transcribed from a heavy chain variable region (VH) gene closely related (and possibly allelic) to VH genes of the C57BL/6 (Ighb) nitrophenyl antibody family. The deduced amino acid sequence corresponding to the light chain variable region of this autoantibody shows extensive similarities with non-autoantibody molecules of the V kappa 1 group, suggesting a common variable gene origin. The joining segments, constant regions, and 3' untranslated regions of both the heavy and light chain mRNAs are nearly identical to corresponding sequences of non-autoantibodies from normal mice. Our findings suggest that this anti-DNA autoantibody originated from the same germline repertoire as antibodies to exogenous antigens.
A Multifunctional Probe with Aggregation‐Induced Emission Characteristics for Selective Fluorescence Imaging and Photodynamic Killing of Bacteria Over Mammalian Cells
Authors: Meng Gao, Qinglian Hu, Guangxue Feng, Nikodem Tomczak, Rongrong Liu, Bengang Xing, Ben Zhong Tang, Bin Liu
Journal: Advanced Healthcare Materials (2014)

A multifunctional probe aggregation-induced emission-Zinc(II)-dipicolylamine (AIE-ZnDPA) is developed for selective targeting, fluorescence imaging, and photodynamic killing of both Gram-positive and Gram-negative bacteria over mammalian cells. The probe has significant advantages in simple probe design, enhanced fluorescence upon bacteria binding, excellent photostability, and broad-spectrum antibacterial activity with almost no harm to mammalian cells.
Fine Mapping of <i>PPH1</i>, a Gene for Familial Primary Pulmonary Hypertension, to a 3-cM Region on Chromosome 2q33
Authors: ZEMIN DENG, FATEMEH HAGHIGHI, LETICIA HELLEBY, KISHA VANTERPOOL, EVELYN M. HORN, ROBYN J. BARST, SUSAN E. HODGE, JANE H. MORSE, JAMES A. KNOWLES
Journal: American Journal of Respiratory and Critical Care Medicine (2000)

Familial primary pulmonary hypertension (PPH) is a rare autosomal dominant disease characterized by distinctive changes in pulmonary arterioles that lead to increased pulmonary artery pressures, right ventricular failure, and death. Our previous studies had mapped the disease locus, PPH1, to a 27-cM region on chromosome 2q31-q33, with a maximum multipoint logarithm of the odds favoring genetic linkage score of 3.87 with markers D2S350 and D2S364. To narrow the minimal genetic region for PPH, we physically mapped 33 highly polymorphic microsatellite markers and used them to genotype 44 affected individuals and 133 unaffected individuals from 17 families with PPH. We observed recombination events that substantially reduced the interval for PPH1 to the approximately 3-cM region that separates D2S311 and D2S1384. This entire region lies within chromosome 2q33. A maximum two-point lod score of 7.23 at a recombination fraction of zero was obtained for marker D2S307. A maximum multipoint lod score of 7.41 was observed close to marker D2S1367. The current minimal genetic region contains multiple candidate genes for PPH, including a locus thought to play a role in lung cancer.
The Education of Tseng
Authors: Malcolm C. Todd
Journal: JAMA (1975)

To the Editor.—  Even now, eight months after my visit to the People's Republic of China as a representative of the American Medical Association, my thoughts frequently turn to Tseng Hsien Chu—especially as I tour our American medical schools.  The remarkable thing about Tseng is not that he is a 23-year-old, thirdyear medical student in China. The remarkable thing, from a Western viewpoint, is that my first contact with him was in the surgery of a Canton hospital where I watched him perform a thyroidectomy! And he did a good job, too.  Tseng is not unique in China. Third-year students routinely perform surgery under China's threeyear medical curriculum, which was inaugurated in 1970.  And as a physician vitally concerned with medical education, I found it especially interesting that, like their American counterparts, not everyone is admitted to medical school.  Chinese students must also pass muster before a reviewing committee. But
US Preventive Services Task Force. Occult blood screening for colorectal cancer
Authors: K. K. Knight
Journal: JAMA (1989)

<h3>GENERAL BACKGROUND</h3> Colorectal cancer has long been the target of efforts aimed at early detection. It is the second most common cancer in the United States, with 140 000 new cases and 60 000 deaths estimated to have occurred in 1987.<sup>1</sup>It is uncommon in persons younger than 50 years but its incidence increases sharply thereafter.<sup>2</sup>Investigations into the causes of colorectal cancer have not yielded a consensus strategy for prevention. However, early treatment generally is acknowledged to be more beneficial than late treatment. Early detection would thus seem to be a reasonable approach to lowering the toll of this cancer. The American Cancer Society and the National Cancer Institute recommend yearly occult blood testing for all persons older than 50 years of age.<sup>3,4</sup>The Canadian Task Force on the Periodic Health Examination has recommended the use of fecal occult blood testing by asymptomatic persons older than
Predictive value of airways hyperresponsiveness and circulating IgE for identifying types of responses to toluene diisocyanate inhalation challenge.
Authors: M H Karol, D J Tollerud, T P Campbell, L Fabbri, P Maestrelli, M Saetta, C E Mapp
Journal: American Journal of Respiratory and Critical Care Medicine (1994)

Development of asthma after exposure to toluene diisocyanate (TDI) has been recognized in a variety of occupational settings. However, the pathogenesis of isocyanate-induced asthma remains controversial. In particular, the role of IgE in the development of TDI-induced asthma has remained uncertain. To investigate predictive factors for response to inhalation challenge with TDI, we analyzed data from 63 subjects referred for evaluation of respiratory symptoms thought to be related to TDI sensitization. All subjects underwent interview, routine phlebotomy, spirometry, methacholine challenge, and allergy skin testing prior to TDI challenge. Spirometry and methacholine challenge were repeated 1 day after TDI challenge. The cumulative dose of methacholine needed to produce a 20% decrease in FEV1 (PD20) was determined. A PD20 of 1.4 mg or more was considered normal. Subjects were challenged by exposure to 5 to 10 ppb TDI for up to 30 min in a 9 m3 exposure chamber. A positive response was a 20% or more decrease in FEV1 within 1 h (early) or beyond 1 h (late) after TDI exposure. Thirty-four subjects (54%) had a positive response, of whom 12 (35% of responders) had isolated early responses, 13 (38%) had isolated late responses, and the remainder had dual responses. Thirty-two individuals (51%) had a positive response to methacholine (AR+) prior to TDI challenge. AR+ was strongly associated with a positive TDI challenge: 23 AR+ subjects (72%) had a positive TDI challenge, compared with only 11 AR- subjects (35%) (p < 0.01). AR positivity did not predict the time of onset of TDI response.(ABSTRACT TRUNCATED AT 250 WORDS)
Analysis of H Wave of Ballistocardiogram
Authors: VINCENT DE LALLA, MARVIN A. EPSTEIN, HERBERT R. BROWN
Journal: Circulation (1950)

The observations on which this analysis is based include simultaneous ballistocardiographic and electrocardiographic tracings on subjects with complete heart block, and auricular fibrillation. Deflections of the ballistocardiogram similar to the H wave were seen to occur at a constant time interval after P in the absence of a ventricular systole. However, in fibrillation H waves were also found occasionally. A G wave of the ballistocardiogram is described and the authors discuss the part played by auricular systole, the apex thrust, and venous pressure pulses in producing the G and H waves.
Dysphagia in a 27-year-old man
Authors: A Seicean, R Stan
Journal: Gut (2009)

A 28-year-old man was admitted to our hospital complaining of lower oesophageal dysphagia to solid food of 3 months duration. There was no weight loss or pain. Clinical examination on admission revealed no abnormal findings, and investigations showed no inflammation or anaemia. Barium swallow showed a lacunar image in the distal oesophagus, with normal surrounding folds, suggestive of a benign tumour (fig 1).Upper endoscopy showed a large submucosal tumour, covered by normal mucosa, situated just …
The Vermont Epidemic of Legionnaires' Disease
Authors: CLAIRE V. BROOME
Journal: Annals of Internal Medicine (1979)

Sixty-nine laboratory-documented cases of Legionnaires' disease occurred in Vermont between 1 May and 31 December 1977. Clinical manifestations were similar to those in the 1976 Philadelphia epidemic. Case-control studies suggested that Legionnaires' disease patients were more likely to present with headache or diarrhea than were patients with pneumonia of presumed nonbacterial cause. The case-fatality ratio for patients treated with erythromycin was 4%, compared with 17% in patients not treated with erythromycin. Thirteen patients had been hospitalized throughout the 10 days preceding onset of illness, equaling the maximal known incubation period. This suggests either acquisition or reactivation of infection in the hospital. However, even during the week of peak disease activity, cases occurred in patients with no recent hospital contact. The only community factor possibly associated with acquisition was home air conditioning. This prevalence of seroreactivity to the Legionnaires' disease bacterium in various community populations was as high as 26%, suggesting a possible endemic area.
Determination of Cancer Risk Associated with Germ Line BRCA1 Missense Variants by Functional Analysis
Authors: Marcelo A. Carvalho, Sylvia M. Marsillac, Rachel Karchin, Siranoush Manoukian, Scott Grist, Ramona F. Swaby, Turan P. Urmenyi, Edson Rondinelli, Rosane Silva, Luis Gayol, Lisa Baumbach, Rebecca Sutphen, Jennifer L. Pickard-Brzosowicz, Katherine L. Nathanson, Andrej Sali, David Goldgar, Fergus J. Couch, Paolo Radice, Alvaro N.A. Monteiro
Journal: Cancer Research (2007)

Germ line inactivating mutations in BRCA1 confer susceptibility for breast and ovarian cancer. However, the relevance of the many missense changes in the gene for which the effect on protein function is unknown remains unclear. Determination of which variants are causally associated with cancer is important for assessment of individual risk. We used a functional assay that measures the transactivation activity of BRCA1 in combination with analysis of protein modeling based on the structure of BRCA1 BRCT domains. In addition, the information generated was interpreted in light of genetic data. We determined the predicted cancer association of 22 BRCA1 variants and verified that the common polymorphism S1613G has no effect on BRCA1 function, even when combined with other rare variants. We estimated the specificity and sensitivity of the assay, and by meta-analysis of 47 variants, we show that variants with <45% of wild-type activity can be classified as deleterious whereas variants with >50% can be classified as neutral. In conclusion, we did functional and structure-based analyses on a large series of BRCA1 missense variants and defined a tentative threshold activity for the classification missense variants. By interpreting the validated functional data in light of additional clinical and structural evidence, we conclude that it is possible to classify all missense variants in the BRCA1 COOH-terminal region. These results bring functional assays for BRCA1 closer to clinical applicability.
Cooperative Role of Telomerase Activity and p16 Expression in the Prognosis of Non-Small-Cell Lung Cancer
Authors: R. Gonzalez-Quevedo
Journal: Journal of Clinical Oncology (2002)

PURPOSE: Telomerase activity and p16 expression can be considered two of the most important molecular markers implicated in tumorigenesis. Our main aim was to study the cooperative role of both molecular alterations in the prognosis of patients surgically resected for non–small-cell lung cancer (NSCLC). PATIENTS AND METHODS: We have determined telomerase activity and p16 expression in a series of 98 prospectively collected NSCLC specimens obtained from patients who had undergone surgery without other treatment. Telomerase activity was investigated by a telomeric repeat amplification protocol enzyme-linked immunosorbent assay–based procedure, and p16 expression was examined by Western blot. Associations with survival were evaluated. RESULTS: Positive results for telomerase activity were found in 82% of the cases, and this variable correlated with poor differentiation and recurrence of tumors. Lack of p16 expression was observed in 61% of tumors, and a significant association with tumor recurrence was also ...
Abstract 2651: Association of p53 codon72 polymorphism, BCCIP &amp; CDKN2A with melanoma risk. A p53-dependent mechanism
Authors: Radhika G. Andavolu, Svetlana Rubakovic, Jacob Rubin, Jaski Bir, Shinger Shu, Murthy Andavolu, James Mac Murray
Journal: Cancer Research (2012)

Abstract Cancers arise due to accumulation of mutations in genes critical for cell proliferation, differentiation, and cell death. Direct interaction with cell cycle regulators characterizes growth suppression by several tumor suppressor genes. Mutation or polymorphisms that occur in the promoter or coding regions may affect gene expression and may thus have the potential to be of phenotypic or even of pathological significance. In our previous studies, we showed the differential gene expression patterns and gene interactions/ association of of BCCIP and/or CDKN2A gene1, TNF and/or CCR52 with respect to genotypes, melanoma types and family history. We reported a significant interaction between BCCIP and CDKN2A genotypes among melanoma cases and a significant difference between cases and controls for the BCCIP/CDKN2A haplotype, when adjusted with age and sex, possibly confering different levels of susceptibility to melanoma. In the same report we also had a finding of CDKN2A mutant genotype showing significant association with Melanoma type 1 followed by type 2 suggesting this gene to be critical only in cases with family history and /or with other malignancy. Previous reports have shown that BCCIP as an important component in maintaining the tumor suppression function of wild type p53.Without BCCIP, p53 fails to form tetramers, cannot bind with its target promoter sequences, and is defective in transactivation activity. The p53 pathway responds to cellular stresses that threaten the fidelity of DNA replication, genome stability, chromosome separation and cell division. Many of the cellular stresses can be oncogenic in nature and in skin, the most damaging stresses in carcinogenesis is UV radiation. In this follow up study we show a strong association of p53 codon72 polymorphism (p&amp;lt;0.003) with melanoma (N=126) as compared to controls (N=172). Positive correlations of p53 gene with BCCIP polymorphism (p&amp;lt;.013), BCCIP(p&amp;lt;0.010) &amp; CDKN2A(p&amp;lt;0.032) gene expressions from tumor tissues from melanoma patients suggest the possible functional role of these reported gene interactions in causation or in disease progression. A 12 gene panel (TNF, CCR5 and other CDK pathway genes) and their possible interactions showing clinical relevance of these markers in melanoma development and/or progression through p53-dependent mechanism are discussed. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 103rd Annual Meeting of the American Association for Cancer Research; 2012 Mar 31-Apr 4; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2012;72(8 Suppl):Abstract nr 2651. doi:1538-7445.AM2012-2651
Plasmapheresis Does Not Increase the Risk for Infection in Immunosuppressed Patients with Severe Lupus Nephritis
Authors: Marc A. Pohl, Shu-Ping Lan, Tomas Berl
Journal: Annals of Internal Medicine (1991)

Objective: To determine whether plasmapheresis increases the risk for infection in immunosuppressed patients. Design: Randomized, controlled trial. Setting: Multicenter. Patients: Eighty-six patients enrolled in a trial of plasmapheresis for severe diffuse proliferative lupus nephritis. Interventions: Forty-six of the patients received high-dose steroid therapy plus cyclophosphamide therapy for 8 weeks. Thereafter, cyclophosphamide therapy was discontinued, and steroid therapy was tapered (standard treatment group). Forty patients received identical treatment and had 12 plasmapheresis procedures during the first 4 weeks of the treatment. Measurements: Patients were examined for the development of infection. Main Results: No statistical difference in age, sex, race, serum creatinine level, proteinuria, or complement levels was found between the two groups. Over a follow-up period of 5376 patientweeks, 74% of patients in the standard treatment group had 62 infections, yielding an aggregate infection rate of 1.15 infections per 100 weeks (median individual infection rate, 1.08; 25th and 75th percentiles, 0.0 and 2.44). This rate was comparable to that seen in the plasmapheresis-treated patients who were followed for 4187 patient-weeks: 68% had 51 infections, for an aggregate infection rate of 1.22 infections per 100 weeks (median individual infection rate, 0.94; 25th and 75th percentiles, 0.0 and 2.32). The infection rate was also comparable in the initial acute phase of the study, despite the fact that patients who received plasmapheresis then had significantly lower immunoglobulin (IgG) levels (P < 0.001). Neither the site (superficial compared with systemic) nor the nature (conventional compared with unconventional) of infection differed statistically between the two groups. Of 14 patient deaths, 7 were from infection (4 in the control group and 3 in the plasmapheresis group). Conclusion: Plasmapheresis did not increase the risk for infection in immunosuppressed patients with severe lupus nephritis.
Malnutrition and hunger rise as economic crisis hits world's poorest people
Authors: J. Zarocostas
Journal: BMJ (2009)

The global economic crisis could trigger another worldwide famine, with millions of people losing their jobs in poor nations that already face huge food problems, a top United Nations official has warned.

The number of hungry people in the world could rise this year by up to 100 million—on top of the nearly one billion people who were undernourished in 2008, said David Nabarro, head of the UN’s task force on the global food security crisis.

“We are anticipating, with the reduction in their purchasing power . . . that they are going to be facing extreme problems in ensuring that they can …
Hepatitis C and HIV-1 coinfection
Authors: A H Mohsen, P Easterbrook, C B Taylor, S Norris
Journal: Gut (2002)

Hepatitis C virus (HCV) has emerged as the cause of the second major epidemic of viral infection after human immunodeficiency virus (HIV) within the past two decades, and coinfection of HIV and HCV represents a growing problem for the future. This article reviews the current evidence on the epidemiology and clinical implications of an interaction between HIV-1 and HCV infection, and the current status of the management of patients with combined infection.
Abstract A17: MiR-15, miR-16 and miR-21 are direct transcriptional targets of E2F1 that limit E2F-induced proliferation and apoptosis
Authors: Matan Ofir, Berta Ben-Shachar, Dalia Hacohen, Doron Ginsberg
Journal: Cancer Research (2012)

Abstract microRNAs (miRs) are small non-coding RNA molecules that have recently emerged as critical regulators of gene expression and are often deregulated in cancer. In particular, miRs encoded by the miR-15a, miR-16-1 cluster are frequently deleted in certain cancers and appear to act as tumor suppressors. Furthermore, miR-21 is over-expressed in a wide variety of human tumors and functions as an oncogene. Here, we provide evidence that miR-21, the miR-15a, miR-16-1 cluster and related miR-15b, miR-16-2 cluster comprise miRs regulated by E2F1, a pivotal transcription factor that can induce both proliferation and cell death. E2F1 is a critical downstream target of the tumor suppressor RB. The retinoblastoma pathway is often inactivated in human tumors resulting in deregulated E2F activity. We show that expression levels of the five mature miRs, miR-15a, miR-16-1, miR-15b, miR-16-2 and miR-21 are elevated upon activation of ectopic E2F1. Moreover, activation of endogenous E2Fs up-regulates expression of these miRs and endogenous E2F1 binds their respective promoters. Importantly, we corroborate that miR-15a/b inhibits expression of cyclin E, a key direct transcriptional target of E2F pivotal for the G1/S transition. Similarly, miR-21 inhibits the expression of the pro-apoptotic tumor suppressor gene maspin, another direct transcriptional target of E2F. Therefore, our data suggest the existence of feed forward loops that modulate E2F activity and consist of E2F1; E2F1-regulated miRs -miR-15 and miR-21; and E2F1-regulated genes-cyclin E and maspin. In support of this, ectopic expression of miR-15 inhibits G1/S transition and, conversely, inhibition of miR-15 expression enhances E2F1-induced G1/S transition and up-regulation of cyclin E levels. Also, inhibition of miR-21 expression enhances E2F1-induced up regulation of maspin, as well as E2F1-mediated apoptosis. In summary, our data identify miR-15, miR-16 and miR-21 as novel transcriptional targets of E2F that, in turn, modulate E2F activity. Citation Format: Matan Ofir, Berta Ben-Shachar, Dalia Hacohen, Doron Ginsberg. MiR-15, miR-16 and miR-21 are direct transcriptional targets of E2F1 that limit E2F-induced proliferation and apoptosis [abstract]. In: Proceedings of the AACR Special Conference on Noncoding RNAs and Cancer; 2012 Jan 8-11; Miami Beach, FL. Philadelphia (PA): AACR; Cancer Res 2012;72(2 Suppl):Abstract nr A17.
Use of Phosphate and Vitamin D to Prevent Dwarfism and Rickets in X-Linked Hypophosphatemia
Authors: Francis H. Glorieux, Charles R. Scriver, Terry M. Reade, Hy Goldman, Anne Roseborough
Journal: New England Journal of Medicine (1972)

Abstract Eight children with X-linked hypophosphatemia (three girls and five boys between three and 15 years of age) were treated for a total of 11,297 patient days with an inorganic phosphate salt...
A distinctive nuclear morphology in acute myeloid leukemia is strongly associated with loss of HLA-DR expression and FLT3 internal tandem duplication
Authors: S J Kussick, D L Stirewalt, H S Yi, K M Sheets, E Pogosova-Agadjanyan, S Braswell, T H Norwood, J P Radich, B L Wood
Journal: Leukemia (2004)