MYELOMATOSIS WITH XANTHOMATOSIS
Authors: B FRAME, M R PACHTER, R K NIXON
Journal: Annals of Internal Medicine (1961)

Case Reports1 January 1961MYELOMATOSIS WITH XANTHOMATOSISBOY FRAME, M.D., M. R. PACHTER, M.SC., M.D., R. K. NIXON, M.D.BOY FRAME, M.D.Search for more papers by this author, M. R. PACHTER, M.SC., M.D.Search for more papers by this author, R. K. NIXON, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-54-1-134 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptDuring the last decade considerable attention has been focused on the serum protein aberrations in multiple myeloma.1Little information has been presented, however, regarding the serum lipids and the possibility of deranged lipid metabolism in this disease. Kanzow,2in evaluating 10 patients with macroglobulinemia of Waldenström and five with myelomatosis, observed a marked decrease in serum lipids in a majority of these cases, especially in those with macroglobulinemia. Similar findings of strikingly low cholesterol values in patients with multiple myeloma were noted by Leibetseder,3Gross and Weicker,4and Lewis and Page.5Still other authors have substantiated the presence of low...Bibliography1. KorngoldLipari LR (a) : Multiple-myeloma proteins. Cancer 9: 183, 1956. (b) Petermann, M. L., Hamilton, M. G., Korngold, L.: Multiple-myeloma proteins. Ultracentrifugal and electrophoretic analysis of paucidisperse myeloma globulin. Cancer 9: 193, 1956. CrossrefMedlineGoogle Scholar2. Kanzow U: Untersuchungen über Serumlipoide bei Paraproteinamien. In European Society of Haematology, Transaction of the 6th Congress, 1957, Copenhagen, 1958, S. Karger, Basel, Part 2, p. 103. Google Scholar3. LeibetsederHugentoblerWunderlyWuhrmann FFCF: Untersuchungen über die Serumlipoide und proteine. Wien. Ztschr. inn. Med. 32: 1, 1951. MedlineGoogle Scholar4. GrossWeicker PH: Die Bedeutung des Lipoidelektrophoesediagrammes. Klin. Wchnschr. 32: 509, 1954. CrossrefMedlineGoogle Scholar5. LewisPage LAIH: Serum proteins and lipoproteins in multiple myelomatosis. Amer. J. Med. 17: 670, 1954. CrossrefMedlineGoogle Scholar6. FeiereisSehnert HHE: Seltene Form einer Paraproteinose. Klin. Wchnschr. 32: 998, 1954. CrossrefMedlineGoogle Scholar7. HillMulliganDunlop RMRMSG: Plasma cell myeloma associated with high concentrations of plasma lipoprotein. Amer. J. Path. 24: 688, 1948. MedlineGoogle Scholar8. SachsCadyRoss BAPG: Abnormal lipid-like material and carbohydrate in sera of patients with multiple myeloma. Amer. J. Med. 17: 622, 1954. CrossrefGoogle Scholar9. Waldenström J: Abnormal proteins in multiple myeloma. Advance Intern. Med. 5: 398, 1952. MedlineGoogle Scholar10. SpainGreenblattSnapperCohn DMIJIT: Degree of coronary and aortic atherosclerosis in necropsied cases of multiple myeloma. Amer. J. Med. Sci. 231: 165, 1956. CrossrefMedlineGoogle Scholar11. Lennard-Jones JE: Myelomatosis with xanthomatosis. In European Society of Haematology, Transaction of the 6th Congress, 1957, Copenhagen, 1958, S. Karger, Basel, Part 2, p. 107. Google Scholar12. Lennard-Jones JE: Personal communication, 1959. Google Scholar13. MagaliniStefaniniMarin SIMHM: Diagnostic significance of changes in free, esterified and protein-bound cholesterol, lipo- and glyco-proteins in lymphoma and multiple myeloma. Amer. J. Med. Sci. 231: 155, 1956. CrossrefMedlineGoogle Scholar14. Deuel HJ: Lipids. Vol. 2, 1955, Interscience Publishing Company, New York, p. 370. Google Scholar15. LewisPageThomas LAIHC: Effect of hepatectomy on serum lipoproteins in dogs. Amer. J. Physiol. 172: 83, 1953. CrossrefMedlineGoogle Scholar16. OssermanLawlor EFDP: Abnormal serum and urine proteins in thirty-five cases of multiple myeloma, as studied by filter paper electrophoresis. Amer. J. Med. 18: 462, 1955. CrossrefMedlineGoogle Scholar17. Hollan S, in discussion of Lennard-Jones,11 p. 108. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Detroit, Michigan*Received for publication June 26, 1959.From the Division of General Medicine and the Department of Pathology, Henry Ford Hospital, Detroit, Michigan.†Present address: Memorial Center for Cancer and Allied Diseases, 44 East Sixty-eighth Street, New York 21, N. Y.Requests for reprints should be addressed to Boy Frame, M.D., Henry Ford Hospital, West Grand Boulevard at Hamilton, Detroit 2, Michigan. 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