tbuckley/cabot-search huggingface dataset:
Abstract 12543: Efficacy and Safety of Rivaroxaban in Patients Undergoing Atrial Fibrillation Ablation: Evidence From a Meta-Analysis
Authors: Ramez Nairooz, Partha Sardar, Saurav Chatterjee, Wilbert S Aronow, Debabrata Mukherjee
Journal: Circulation (2014)

Background:  Rivaroxaban is an alternative to warfarin in stroke prevention for non-valvular atrial fibrillation, however safety and efficacy of rivaroxaban in patients undergoing catheter ablation has not been well studied. We aim to investigate the hypothesis that rivaroxaban is equally safe and effective compared to warfarin when used in patients undergoing atrial fibrillation ablation.   Methods:  We reviewed online databases through April 30, 2013 for published articles and conference abstracts comparing rivaroxaban to warfarin in patients undergoing atrial fibrillation ablation. We then performed a meta-analysis to assess safety and efficacy outcomes (Table), using Peto odds ratio, for outcomes with low events rates (   Results:  Our search yielded 5 observational studies; 3 full text articles and 2 conference abstracts. Outcomes data were available for 1691 patients and of those 736 were given rivaroxaban. In 3 of the trials, patients underwent ablation on uninterrupted warfarin. The risk of all thromboembolic events was equal between the two groups; 0.4% with rivaroxaban and 0.8% with warfarin [Peto’s odds ratio (POR) 0.50, 95% confidence interval (CI) 0.14- 1.71; p=0.27]. The risk of stroke with rivaroxaban was also comparable to warfarin (POR 0.30, 95% CI 0.05, 1.77; p=0.19). A trend of lower major bleeding risk was observed with rivaroxaban compared to warfarin (1.2% versus 2.1%; OR 0.50, 95% CI 0.23- 1.08); p=0.08). Minor bleeding was no different (3.8% versus 4.6; OR 0.97. 95% CI 0.59-1.61; p=0.91)   Conclusion:  In patients with atrial fibrillation undergoing ablation, rivaroxaban appears equally effective compared to warfarin, and had a trend for lower major bleeding risk.
Abstract 20319: Aging is Associated With Abnormal Wave Hemodynamics in the Carotid Artery
Authors: Julio A Chirinos, Marc De Buyzere, Ernst Rietzschel, Thierry Gillebert, Ritchie Verma, Snigdha Jain, Patrick Segers
Journal: Circulation (2014)

Background: Advanced age is associated with microvascular disease in the brain. Recent evidence suggest that abnormal central pulsatile hemodynamics play a role in the pathogenesis of microvascular disease in the brain, since this high-flow organs is particularly sensitive to excessive pulsatility due to its low microvascular resistance. However, how aging changes the pulsatile hemodynamic patterns in the carotid artery is incompletely understood, particularly in middle-age. Hypothesis: Aging is associated with abnormal wave patterns in the carotid artery. Methods: We studied 2168 men and women participants in the community-based Asklepios study in Belgium (mean age=45.9±6 years).We measured carotid pressure and flow with arterial tonometry and Doppler ultrasound, respectively. Wave intensity analysis was applied to quantify the energy in forward- and backward-traveling carotid waves. Results: Despite being associated with increased carotid pulse pressure (beta=0.22; P<0.0001) and mean flow velocity (β=0....
Study Reveals Mitochondrial Role in Aging
Authors: Tracy Hampton
Journal: JAMA (2005)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Optimized Prognostic Score for Coronary Computed Tomographic Angiography
Authors: Martin Hadamitzky, Stephan Achenbach, Mouaz Al-Mallah, Daniel Berman, Matthew Budoff, Filippo Cademartiri, Tracy Callister, Hyuk-Jae Chang, Victor Cheng, Kavitha Chinnaiyan, Benjamin J.W. Chow, Ricardo Cury, Augustin Delago, Allison Dunning, Gudrun Feuchtner, Millie Gomez, Philipp Kaufmann, Yong-Jin Kim, Jonathon Leipsic, Fay Y. Lin, Erica Maffei, James K. Min, Gil Raff, Leslee J. Shaw, Todd C. Villines, Jörg Hausleiter
Journal: Journal of the American College of Cardiology (2013)
Control and Prevention of Hemorrhage: Platelet Separation
Authors: Edmund Klein, Sidney Farber, Isaac Djerassi
Journal: Cancer Research (1965)

Summary  The development of methods for the separation and concentration of human platelets permitted their administration in sufficient quantities to control bleeding in thrombocytopenia.  Methods for separation and concentration of human platelets, by which platelet preparations can be provided as by-products of routine blood banking, have been described.  Platelet transfusions are safe and effective in the control of thrombocytopenic bleeding.
English melanoma by body site: keep wearing the trousers?
Authors: N.J. Levell
Journal: British Journal of Dermatology (2011)

Journal Article English melanoma by body site: keep wearing the trousers? Get access N.J. Levell N.J. Levell Department of Dermatology, Norfolk and Norwich University Hospital, Norwich NR4 7UY, U.K. E‐mail: nick.levell@nnuh.nhs.uk Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 165, Issue 4, 1 October 2011, Pages 709–710, https://doi.org/10.1111/j.1365-2133.2011.10549.x Published: 01 October 2011
CD8<sup>+</sup>Sézary syndrome with interleukin-22 production modulated by bacterial sepsis
Authors: T. Shimauchi, K. Sasada, Y. Kito, T. Mori, M. Hata, T. Fujiyama, T. Ito, S. Hirakawa, Y. Tokura
Journal: British Journal of Dermatology (2012)

Journal Article CD8+ Sézary syndrome with interleukin‐22 production modulated by bacterial sepsis Get access T. Shimauchi, T. Shimauchi Department of Dermatology, Hamamatsu University School of Medicine, 1‐20‐1, Handayama, Higashi‐ku, Hamamatsu, 431‐3192, Japan Search for other works by this author on: Oxford Academic Google Scholar K. Sasada, K. Sasada Department of Dermatology, Hamamatsu University School of Medicine, 1‐20‐1, Handayama, Higashi‐ku, Hamamatsu, 431‐3192, Japan Section of Dermatology, Numazu City Hospital, Numazu, Japan E‐mail: t-shima@hama-med.ac.jp Search for other works by this author on: Oxford Academic Google Scholar Y. Kito, Y. Kito Department of Dermatology, Hamamatsu University School of Medicine, 1‐20‐1, Handayama, Higashi‐ku, Hamamatsu, 431‐3192, Japan Search for other works by this author on: Oxford Academic Google Scholar T. Mori, T. Mori Section of Dermatology, Numazu City Hospital, Numazu, Japan E‐mail: t-shima@hama-med.ac.jp Search for other works by this author on: Oxford Academic Google Scholar M. Hata, M. Hata Section of Dermatology, Numazu City Hospital, Numazu, Japan E‐mail: t-shima@hama-med.ac.jp Search for other works by this author on: Oxford Academic Google Scholar T. Fujiyama, T. Fujiyama Department of Dermatology, Hamamatsu University School of Medicine, 1‐20‐1, Handayama, Higashi‐ku, Hamamatsu, 431‐3192, Japan Search for other works by this author on: Oxford Academic Google Scholar T. Ito, T. Ito Department of Dermatology, Hamamatsu University School of Medicine, 1‐20‐1, Handayama, Higashi‐ku, Hamamatsu, 431‐3192, Japan Search for other works by this author on: Oxford Academic Google Scholar S. Hirakawa, S. Hirakawa Department of Dermatology, Hamamatsu University School of Medicine, 1‐20‐1, Handayama, Higashi‐ku, Hamamatsu, 431‐3192, Japan Search for other works by this author on: Oxford Academic Google Scholar Y. Tokura Y. Tokura Department of Dermatology, Hamamatsu University School of Medicine, 1‐20‐1, Handayama, Higashi‐ku, Hamamatsu, 431‐3192, Japan Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 168, Issue 4, 1 April 2013, Pages 881–883, https://doi.org/10.1111/bjd.12051 Published: 01 April 2013
Direct evidence for new T-cell generation by patients after either T-cell–depleted or unmodified allogeneic hematopoietic stem cell transplantations
Authors: Sharon R. Lewin, Glenn Heller, Linqi Zhang, Elaine Rodrigues, Eva Skulsky, Marcel R. M. van den Brink, Trudy N. Small, Nancy A. Kernan, Richard J. O'Reilly, David D. Ho, James W. Young
Journal: Blood (2002)
Guide to caring for Muslim patients published
Authors: Zosia Kmietowicz
Journal: BMJ (2000)

A newly published guide to the Muslim religion, and its possible impact on the use of health care, could pave the way for better understanding of the role of religion in the use of and attitude to health and medicine.

Taking a non-prescriptive and patient centred approach, the book covers Muslim customs such as pilgrimage, fasting, and grieving …
Does a Genetic Variant in <i>FOXO3A</i> Predict a Milder Course of Rheumatoid Arthritis?
Authors: H. W. van Steenbergen, S. Rantapää‐Dahlqvist, J. A. B. van Nies, E. Berglin, T. W. J. Huizinga, P. K. Gregersen, A. H. M. van der Helm‐van Mil
Journal: Arthritis & Rheumatology (2014)
Regulation of tyrosine kinase activation and granule release through β-arrestin by CXCR1
Authors: Jana Barlic, Joseph D. Andrews, Alyson A. Kelvin, Steven E. Bosinger, Mark E. DeVries, Luoling Xu, Tomas Dobransky, Ross D. Feldman, Stephen S. G. Ferguson, David J. Kelvin
Journal: Nature Immunology (2000)
THE STATE OF SENSORY AND MOTOR CENTERS IN PATIENTS WITH HYPOTHYROIDISM
Authors: Norbert Enzer, Ernst Simonson, Samuel S. Blankstein
Journal: Annals of Internal Medicine (1941)

Article1 October 1941THE STATE OF SENSORY AND MOTOR CENTERS IN PATIENTS WITH HYPOTHYROIDISMNORBERT ENZER, M.D., F.A.C.P., ERNST SIMONSON, M.D., SAMUEL S. BLANKSTEIN, M.D.NORBERT ENZER, M.D., F.A.C.P.Search for more papers by this author, ERNST SIMONSON, M.D.Search for more papers by this author, SAMUEL S. BLANKSTEIN, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-15-4-659 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptINTRODUCTIONIncreased fatigability and sluggishness are notable complaints and symptoms of patients with endocrine disturbances, particularly in those with a reduced metabolic rate. Since increased fatigability results also from mental work and is present even under resting conditions in these patients it occurred to us that it might be due to an impairment of some functions of the central nervous system. The metabolism of nerve tissue, like that of other tissues, is influenced and regulated by hormonal factors, particularly when oxygen utilization is affected. Disturbances of nervous functions are, therefore, to be expected when there are pathological alterations in the...References1. GRANIT R: Die Electrophysiologic der Netzhaut und des Sehnerven, Acta Ophth., 1936, xiv, Suppl. viii, i. Google Scholar2. ELSBERGSPOTNITZ ACH: The sense of vision. III. A theory of the functions of the retina, Bull. Neurol. Inst. New York, 1937, vi, 253. Google Scholar3. HECHT S: The nature of the visual processes, Bull. New York Acad. Med., 1938, xiv, 21. Google Scholar4. CROZIER JW: On the sensory discrimination of intensities, Proc. Nat. Acad. Sci., 1936, xxii, 412. CrossrefGoogle Scholar5. SIMONSONENZER EN: Influence of fatigue on the fusion frequency of flicker, Jr. Indust. Hyg., 1941, xxiii, 83. Google Scholar6. MCCURDY JH: The physiology of exercise, 1939, Philadelphia. Google Scholar7. LEHMANN G: Ueber den Mechanismus der Willkuerbewegung, Arbeitsphysiologie, 1928, i, 1. Google Scholar8. BERTRANDDELARYGUILLAIN FJJ: L'Électroencephalogramme dans le myoedème, Compt. rend. Soc. d. biol., Paris, 1938, cxxix, 395. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Milwaukee, Wisconsin*Received for publication November 19, 1940.From the Research Laboratory of the Mount Sinai Hospital, Milwaukee, Wisconsin. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byThyroid hormone regulates excitability in central neurons from postnatal ratsFlicker fusion nitroglycerin tests in normal young adultsA New Electronic Apparatus for the Measurement of the Fusion Frequency of Flicker 1 October 1941Volume 15, Issue 4Page: 659-665KeywordsCentral nervous systemHypothyroidismNervesOxygenResearch laboratories ePublished: 1 December 2008 Issue Published: 1 October 1941 PDF downloadLoading ...
Subthreshold depression and depressive disorder: clinical characteristics of general medical and mental health specialty outpatients
Authors: C D Sherbourne, K B Wells, R D Hays, W Rogers, M A Burnam, L L Judd
Journal: American Journal of Psychiatry (1994)

The authors examined the clinical significance of depressive symptoms below the threshold for depressive disorder in outpatient samples.The subjects were 775 adult patients with current depressive disorder, 1,420 patients with subthreshold depression, and 1,767 hypertensive patients with and without depression, all of whom were visiting the offices of mental health specialists and general medical care providers in three U.S. cities. Data on demographic characteristics, severity of depression, extent of psychiatric and medical comorbidity, family psychiatric history, and treatment history for the patients with depressive disorder and those with subthreshold depression were compared.The percentage of patients with subthreshold depression who had a family history of depression (41%) was nearly as high as that of the patients with depressive disorder (59%). The two groups of patients had similar levels of medical and psychiatric comorbidity except for anxiety disorders, which were greater among the patients with depressive disorder. Among the hypertensive patients in the general medical sector, those with subthreshold depression were more similar to those with depressive disorder than to the nondepressed hypertensive patients. Treatment rates were considerably lower for patients with subthreshold depression than for patients with depressive disorder in the general medical sector, but they were similar in the mental health specialty sector.In these outpatients, subthreshold depression appeared to be a variant of affective disorder and was treated as such in the mental health specialty sector but not in the general medical sector. The findings emphasize the importance of treatment outcome studies of patients with subthreshold depression.
Dementia and Driving
Authors: D O'Neill, K Neubauer, M Boyle, J Gerrard, D Surmon, G K Wilcock
Journal: Journal of the Royal Society of Medicine (1992)

Many European countries test cars, but not their drivers, as they age. There is evidence to suggest that human factors are more important than vehicular factors as causes of motor crashes. The elderly also are involved in more accidents per distance travelled than middle-aged drivers. As the UK relies on self-certification of health by drivers over the age of 70 years, we examined the driving practices of patients with dementia attending a Memory Clinic. Nearly one-fifth of 329 patients with documented dementia continued to drive after the onset of dementia, and impaired driving ability was noted in two-thirds of these. Their families experienced great difficulty in persuading patients to stop driving, and had to invoke outside help in many cases. Neuropsychological tests did not help to identify those who drove badly while activity of daily living scores were related to driving ability. These findings suggest that many patients with dementia drive in an unsafe fashion after the onset of the illness. The present system of self-certification of health by the elderly for driver-licensing purposes needs to be reassessed.
Abstract 716: ASPH_0047: a potent and selective antisense oligonucleotide-targeting transforming growth factor beta 2 (TGF-β2)
Authors: Katja Wosikowski, Frank Jaschinski, Hanna Kohonen, Stephan Braun, Eugen Leo, Michel Janicot
Journal: Cancer Research (2014)

Abstract Transforming growth factor beta (TGF-β) is a key member of a large family of cytokines, including bone morphogenetic protein (BMP), nodals, activins and others, which play critical, pleiotropic roles in the pathophysiology of various human diseases, such as cancer, inflammation, autoimmune disease, and cirrhosis/fibrosis. In particular, the different TGF-β isoforms (TGF-β1, -β2, and -β3, encoded by different genes but sharing high sequence and structure homology) are overexpressed in many human tumors. Correlations between TGF-β expression, cancer stage and clinical parameters have been reported and linked to poor clinical outcome. TGF-β has been associated with a wide range of tumor-promoting processes, including tumor cell invasion and migration, angiogenesis, immunosuppression, as well as tumor stem cell maintenance and protection. Therefore, blocking the TGF-β signaling pathway via inhibition of TGF-β expression appears as an attractive therapeutic intervention in Oncology. We have previously reported the rational design and preliminary outcome of an extensive discovery program for identification of antisense oligodeoxynucleotides targeting the various TGF-β isoforms. We present here ASPH_0047, a 17-mer LNA-modified gapmer based on the sequence of the human TGF-β2 mRNA, as novel preclinical development candidate. ASPH_0047 shows potent and selective target downregulation (mRNA and protein) in various cell-based assays. Preliminary preclinical biodistribution studies in rodent point at tissue penetration in expected target organs (e.g., liver, kidney, spleen) and accumulation in tumor tissue consistent with observed target downregulation and efficacy in relevant in vivo experimental antitumor models. Key pharmacology properties and preclinical features of ASPH_0047 supporting rapid advancement to clinical development will be presented. Citation Format: Katja Wosikowski, Frank Jaschinski, Hanna Kohonen, Stephan Braun, Eugen Leo, Michel Janicot. ASPH_0047: a potent and selective antisense oligonucleotide-targeting transforming growth factor beta 2 (TGF-β2). [abstract]. In: Proceedings of the 105th Annual Meeting of the American Association for Cancer Research; 2014 Apr 5-9; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2014;74(19 Suppl):Abstract nr 716. doi:10.1158/1538-7445.AM2014-716
Treatment with humanized monoclonal antibody against CD154 prevents acute renal allograft rejection in nonhuman primates
Authors: Allan D. Kirk, Linda C. Burkly, D. Scott Batty, Roxanne E. Baumgartner, Justin D. Berning, Kelvin Buchanan, John H. Fechner, Rhonda L. Germond, Robert L. Kampen, Noelle B. Patterson, S. John Swanson, Douglas K. Tadaki, Christopher N. TenHoor, Leonard White, Stuart J. Knechtle, David M. Harlan
Journal: Nature Medicine (1999)
A comparison of recombinant Hirudin with Heparin for the treatment of acute coronary syndromes. The Global Use of Strategies to Open Occluded Coronary Arteries (GUSTO) IIb Investigators
Authors: Maarten Simoons
Journal: New England Journal of Medicine (1996)

textabstractBACKGROUND: Thrombin has a pivotal role in the pathogenesis of acute coronary thrombosis. We compared the clinical efficacy of a potent, direct thrombin inhibitor, recombinant hirudin, with that of heparin (an indirect antithrombin agent) in patients with unstable angina or acute myocardial infarction. METHODS: At 373 hospitals in 13 countries, 12,142 patients with acute coronary syndromes were randomly assigned to 72 hours of therapy with either intravenous heparin or hirudin. Patients were stratified according to the presence of ST-segment elevation on the base-line electrocardiogram (4131 patients) or its absence (8011 patients), with the latter characteristic considered to indicate unstable angina or non-Q-wave myocardial infarction. RESULTS: At 24 hours, the risk of death or myocardial infarction was significantly lower in the group assigned to hirudin therapy than in the group assigned to heparin (1.3 percent vs. 2.1 percent, P = 0.001). The primary end point of death or nonfatal myocardial infarction or reinfarction at 30 days was reached in 9.8 percent of the heparin group as compared with 8.9 percent of the hirudin group (odds ratio for the risk of the end point in hirudin group,0.89; 95 percent confidence interval, 0.79 to 1.00; P = 0.06). The predominant effect of hirudin was on myocardial infarction or reinfarction and was not influenced by ST-segment status. There were no significant differences in the incidence of serious or life-threatening bleeding complications, but hirudin therapy was associated with a higher incidence of moderate bleeding (8.8 percent vs. 7.7 percent, P = 0.03). CONCLUSIONS: For acute coronary syndromes, recombinant hirudin provided a small advantage, as compared with heparin, principally related to a reduction in the risk of nonfatal myocardial infarction. The relative therapeutic effect was more pronounced early (at 24 hours) but dissipated over time. The small benefit was consistent across the spectrum of acute coronary syndromes and was not associated with a greater risk of major bleeding complications.
FAMILIAL MYASTHENIA GRAVIS
Authors: LODOVICO MANCUSI-UNGARO, M.D., F.A.C.P.
Journal: Annals of Internal Medicine (1945)

ExcerptThe etiology of myasthenia gravis is still a much debated question. The influence of heredity on the disease has not been accepted by the great majority of observers. Authorities like Ford,1 Cruschman,2 McCarthy,3 Wilson,4 Wechsler,5 Campbell and Bramwell6 have rejected it and Viets7 hesitated to pass an opinion. However, Keschner and Strauss8 suggest a congenital disposition to the disease; and Bing,9 Riley and Frocht,10 Marinesco,11 Hart,12 and Rothbart,13 each reporting cases of familial myasthenia gravis, believe in some hereditary influence.Since the only way to prove or disprove each theory is to add more case reports to the few on...