tbuckley/cabot-search huggingface dataset:
Abstract 83: Effect of Therapeutic Hypothermia on Oxygenation Index in Rat Model of Cardiac Arrest
Authors: Haifang Yu, Lu Yin, Ping Gong, Jiangang Wang, Zhengfei Yang, Shen Zhao, Jie Qian, Xiaobo Wu, Jena Cahoon, Wanchun Tang
Journal: Circulation (2014)

Introduction: Therapeutic hypothermia improves the outcomes of cerebral function after resuscitation from cardiac arrest (CA). The effect of therapeutic hypothermia on post resuscitation pulmonary function, however, is less known. In the present study, we investigated the effect of therapeutic hypothermia on oxygenation index, a sensitive index of pulmonary function,in a rat model of cardiac arrest and resuscitation. Hypothesis: We hypothesize that during therapeutic mild hypothermia in a rat model of cardiac arrest, the pulmonary function following resuscitation is less impaired when compare to normothermia. Methods: Twenty-one male Sprague-Dawley rats were randomized into three groups: 1) control group (control, n=5): the normothermic rats only received anesthesia and the surgical procedure as the other groups without ventricular fibrillation (VF); 2) normothermia group (NT, n=7): the normothermic rats were subjected to induced VF for 8 mins followed by 8 mins of cardiopulmonary resuscitation (CPR); 3) Mild hypothermia group (HT, n=9): the rats were subjected to induced VF for 8 mins followed by 8 mins of CPR. Mild hypothermia of 33±0.5°C was started 5 mins after return of spontaneous circulation (ROSC) and maintained for 8 hrs. The oxygenation indexes were measured at baseline, 2, 4 or 8 hours after ROSC with a conventional blood gas analyzer (PHOX plus L; Nova Biomedical Corporation, Waltham, MA, USA). Results: Compared to the control group, the oxygenation indexes of both the NT and HT groups were significantly decreased at 2 hrs after ROSC. However, more significant reduction in oxygenation index was observed in the NT group (Figure). Conclusions: There is an early pulmonary dysfunction after successful resuscitation from cardiac arrest. Hypothermia reduces the impairment of pulmonary function.
Mass spectrometry-based proteomic analyses of the cell surface of lung cancer reveals candidate biomarkers of disease and therapeutic response
Authors: Elizabeth G. Joseloff, Tao He, Charles E. Birse, William Fitzhugh, Chad Danis, Kim Rosenthal, Anne Deslattes Mays, Katherine M. McKinnon, Karen Van Orden, Steve M. Ruben, Paul A. Moore
Journal: Clinical Cancer Research (2006)

A114   Introduction:Lung cancer is the most commonly diagnosed cancer worldwide and a leading cause of cancer-related deaths. With a 5-year survival rate of 15%, there is a clear need for improved lung cancer therapeutics and diagnostic biomarkers to guide patient treatment options. Towards this end, we have performed mass spectrometry (MS) analysis of lung cancer cell lines and fresh lung tumors together with normal tissue samples for comparison. Analysis focused on the cell surface proteome to identify both therapeutic antibody targets and diagnostic biomarkers.Methodology: To reduce complexity for MS and to enrich for the plasma membrane proteome, a sequential process was incorporated including isolation of viable cells from fresh tissues, enrichment of epithelial cells, capture of plasma membrane proteins, and capture of cysteine tryptic peptides. Peptide ions were identified by liquid chromatography-MS analysis followed by MS/MS analysis and the MS/MS spectra searched against protein databases.Results: Greater than 450 cell surface and secreted proteins were identified as at least 4 fold over-expressed in lung cancer which included known cancer-related proteins such as EGFR, CD44, and CEACAM1. Functional family classification indicated approximately 20% were cell adhesion proteins, 15% were kinase/receptor proteins, and 10% transporter proteins. Correlating MS data with clinical information allowed for evaluation of protein expression across disease staging and histological type. IHC and flow cytometry (FACS) on a subset of targets validated over-expression in lung cancer and expanded the expression profile in lung cancer and other cancers. Additionally, we have utilized the lung cancer cell surface proteome data to identify candidate predictive markers of response in cancer cell lines with varying sensitivity to lung cancer chemotherapeutics and targeted kinase inhibitors.  Where feasible, we confirmed differential expression by FACS and examined expression in lung tumors by MS.Conclusions: MS analysis of lung tumors and cancer cell lines revealed more than 450 over-expressed cell surface/secreted proteins which, in association with clinical data, could assist with disease classification. We have utilized MS to demonstrate differential expression of cell surface proteins in lung cancer cell lines displaying varying sensitivities to chemotherapeutics. The results from this study demonstrate that MS Proteomics can be an effective platform for identifying both candidate biomarkers of disease and predictive biomarkers of therapeutic response.
Correlation of Clinical Findings with Quinacrine-Banded Chromosomes in 90 Adults with Acute Nonlymphocytic Leukemia
Authors: Harvey M. Golomb, James W. Vardiman, Janet D. Rowley, Joseph R. Testa, Uri Mintz
Journal: New England Journal of Medicine (1978)

We observed chromosome-banding abnormalities in leukemic cells of 46 of 90 (51 per cent) adults with acute nonlymphocytic leukemia at initial hospital admission. The difference in survival between 37 treated patients with an initially normal karyotype (10 months) and 43 with an initially abnormal karyotype (four months) was significant (P less than 0.01). When patients were classified as having acute myelogenous leukemia or acute myelomonocytic leukemia, this difference in survival was even more pronounced. Of 16 treated patients with acute myelogenous leukemia and a normal karyotype, 11 (69 per cent) had a complete remission and a median survival of 13 months. Of eight patients with acute myelogenous leukemia in whom only abnormal metaphases were observed, none had a complete remission, and the median survival was only two months (P approximately 0.50). Remission rate and median survival were not significantly different in patients with acute myelomonocytic leukemia grouped according to initial karyotypes.
Abstract 18828: Role of Age and Sex in Short-term Mortality After STEMI in Eastern Europe: the ISACS-TC Initiative
Authors: Raffaele Bugiardini, Edina Cenko, Sasko Kedev, Marija Vavlukis, Zorana Vasiljevic, Maria Dorobantu, Olivija Gustiene, Bozidarka Knezevic, Davor Milicic, Mirza Dilic, Dijana Trninic, Olivia Manfrini
Journal: Circulation (2014)

Introduction: Previous works have shown that women hospitalized with STEMI have higher short-term mortality rates than men. However, it is unclear if these differences persist among patients undergoing contemporary primary PCI. Hypothesis: We sought to investigate whether the risk of in-hospital death after STEMI is higher in women than men and, if so, to assess the role of age, medications and primary PCI in this excess of risk. Methods: From January 2010 to May 2014, a total of 6690 patients have been hospitalized and received medical treatment for STEMI in 57 hospitals, referring data to the International Survey of Acute Coronary Syndromes in Transitional Countries (ISACS-TC) registry (NCT01218776). Logistic regression model was adjusted to covariates significantly different between groups in univariate analysis. The endpoint was in-hospital mortality after STEMI. Results: There were 2070 women and 4620 men. Women were older than man, with a higher prevalence of risk factors and comorbidities. Fewer wo...
Küçük çocuklarda akut hemorajik ödem (rozet benzeri purpura ve ödem): Olgu serileri ve sistematik gözden geçirme
Authors: Elisabetta Fiore, Mattia Rizzi, Monica Ragazzi, Federica Vanoni, Mara Bernasconi, Mario G. Bianchetti veGiacomo D. Simonettib
Journal: Journal of the American Academy of Dermatology (2009)
Pragmatism Instead of Mechanism
Authors: Martin P. Paulus
Journal: JAMA Psychiatry (2015)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Psychiatry HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Psychiatry journal
Isolation of Enteric Viruses in Ontario During 1960-1962
Authors: A E KELEN, D BELBIN, J M LESIAK, N A LABZOFFSKY
Journal: JAMA (1963)

During the past three years at the Central Laboratory, Ontario Department of Health, 681 isolations were made in tissue culture from 6822 specimens submitted for virus studies by physicians and hospitals from all over Ontario. Nearly 74% of the isolates were enteroviruses, approximately 5% adenoviruses and about 1% reoviruses. The remaining 20% are still to be identified.Although the bulk of isolations was made during the same three-month period (August, September and October) of each year, the predominant virus types varied from year to year. Poliovirus 1 was most commonly encountered in 1960, Coxsackie B5 in 1961 and Echo 9 in 1962.Among other types isolated in smaller numbers were Coxsackie A1, 9 and 10, Coxsackie B1, 2, 3 and 4, Echo 1, 2, 5, 6, 7, 8, 11, 14, 17, 18 and 19, Reovirus 1, 2 and 3, Adenovirus 1, 2, 3, 4, 5, 7 and 16, as well as Frater-type virus. Most of these types were isolated for the first time in Ontario and represent additions to the existing list of viruses known to occur in this province.
Ireland sees big increase in caesarean sections
Authors: Doug Payne
Journal: BMJ (2000)

The Republic of Ireland, which has traditionally had an extremely low rate of caesarean births is now experiencing a dramatic increase in surgical deliveries.

Despite government initiatives to reduce the number of caesareans, the number of babies being delivered surgically has doubled, or tripled, at many maternity units during the past 10 years.

Reasons cited for the rise include better detection of fetal distress, more older women having babies, an increased tendency among patients to resort to litigation, doctors wanting to speed up births, and patients' preference.

But patients' …
The psychological effects of isolation in protected environments
Authors: Jonathan Kellerman, David Rigler, Stuart E. Siegel
Journal: American Journal of Psychiatry (1977)

The authors questioned the directors of 13 protected-environment installations on the psychological effects of protected environment treatment. Psychological problems reported included anxiety, depression, sleep disturbance, withdrawal, regression, and hallucinations. Children seemed to adapt better than adults to protected environments. Respondents recommended the use of preentry orientation, structured recreation programs, steps to prevent time disorientation, and psychological support for both patients and staff to minimize the psychological effects of treatment in protected environments.
Hypothalamic-pituitary-adrenocortical activity and response to cognitive behavior therapy in unmedicated, hospitalized depressed patients
Authors: M E Thase, S Dubé, K Bowler, R H Howland, J E Myers, E Friedman, D B Jarrett
Journal: American Journal of Psychiatry (1996)

Surprisingly little research supports the hypothesis that depressions characterized by objective measures of neurobiological dysregulation respond poorly to psychotherapy. Moreover, relevant studies testing this hypothesis have been compromised by low rates of neurobiological abnormality in outpatient samples. The authors therefore investigated response to cognitive behavior therapy in relation to pretreatment measures of hypothalamic-pituitary-adrenocortical (HPA) activity in hospitalized, yet unmedicated, patients.The subjects were 29 unmedicated, hospitalized patients with major depression (DSM-III-R and Schedule for Affective Disorders and Schizophrenia/Research Diagnostic Criteria), nonpsychotic/nonbipolar subtype. After a 7- to 14-day evaluation, urinary free cortisol levels and dexamethasone suppression tests (DSTs) were obtained. Patients were treated for an average of 3 weeks with intensive individual cognitive behavior therapy. Response was assessed in relation to clinical severity of illness and pretreatment HPA parameters.Response to inpatient cognitive behavior therapy was inversely associated with pretreatment urinary free cortisol concentrations, although not strongly correlated with DST results. Overall, 12 (92%) of 13 cortisol suppressors on the DST who had normal urinary free cortisol concentrations responded to treatment, compared with only seven (44%) of the 16 patients characterized by nonsuppression of cortisol and/or elevated urinary free cortisol excretion. The relation between response to cognitive behavior therapy and HPA activity was not explained by clinical measures of symptom severity.Results are consistent with the hypothesis that patients with increased HPA function are less responsive to psychotherapy and, hence, might require somatic interventions. It is proposed that the negative impact of hypercortisolism on neurocognitive function mediates this relationship.
Abstract 18623: Evaluation of Left Ventricular Geometry Changes in Patients with Tight Aortic Stenosis Using Multi-detector Computed Tomography
Authors: Jeong Yoon Jang, Dong Hyun Yang, Sang Soo Cheon, Hee-Soon Park, Min Su Kim, Hyo In Choi, Hanul Choi, Jae-hyung Roh, Byung Joo Sun, Joon-Won Kang, Dae-Hee Kim, Jong-Min Song, Duk-Hyun Kang, Jae-Kwan Song
Journal: Circulation (2014)

Background: Although aortic stenosis (AS) is a prototype of left ventricular hypertrophy (LVH) due to pressure overloading, patterns of LV geometric changes in patients with tight AS and their potential impact remain to be established. Methods: LV mass index (LVMI), LV end-diastolic volume (LVEDV) and regional LV wall thickness in 16 segments were measured in 147 patients with tight AS (indexed aortic valve area [AVA] &lt; 0.6 cm 2 /m 2 ) using multi-detector computed tomography and compared with those of 32 normal controls. LVH was defined as LVMI &gt;95 th percentile of normal controls and LV remodeling as increased LVM/LVEDV with normal range of LVMI. Asymmetric remodeling or hypertrophy were used for patients with septal wall thickness &gt;1.5 fold compared to the opposite segment. Patients with increased LVMI but normal range of LVM/LVEDV were classified to have eccentric LVH and those with eccentric LVH and decreased LV systolic function were defined to have de-compensation. Results: AS patients with mean indexed AVA of 0.36 ± 0.08 cm 2 /m 2 showed 7 different patterns of LV geometry including normal LV geometry (n=44), remodeling (n=7), asymmetric remodeling (n=7), concentric hypertrophy (n=16), asymmetric hypertrophy (n=23), eccentric hypertrophy (n=38), and de-compensation (n=12). Peak transaortic velocity (r=0.31, p&lt;0.001) and E/E’ (r=0.29, p&lt;0.001) showed positive correlation with LVMI: compared to other groups, patients with LVH (concentric or asymmetric or eccentric) showed higher peak velocity and E/E’ with smaller AVA (all, p&lt;0.001). Despite similar AVA and mean pressure gradient, patients with E/E’ ≥ 15 (n=110) showed different LV remodeling patterns (p=0.028) with higher LVMI (97.8 ± 21.1 vs 86.4 ± 20.2 g/m 2 , p=0.005). Conclusions: Various remodeling patterns of LV geometry were observed in tight AS and individual variation in LVH severity under similar LV pressure overloading could explain different severity of diastolic dysfunction.
The Histophathology of Appendiceal Amebiasis With Case Report
Authors: Winston F. Harrison
Journal: Annals of Internal Medicine (1929)

Article1 April 1929The Histophathology of Appendiceal Amebiasis With Case ReportWINSTON F. HARRISON, M.D., C.M.WINSTON F. HARRISON, M.D., C.M.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-2-10-1081 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe case to be reported is of interest first of all because the patient had never been farther south than the State of Michigan. Secondly, the case presents some features rarely found even in districts where the disease is prevalent. Lastly, it is peculiar in the mode of diagnosis, which was made by study of the vermiform appendix in the course of the routine histopathological examination of material from the surgical clinic. Since the first reported case of amebic dysentery in the State of Michigan by Dock1in 1902 there have been from time to time reports which indicate that...References(1) DOCK G: Amebic Dysentery in Michigan. Jour. Am. Med. Asso., Sept. 13, 1902, p. 617. CrossrefGoogle Scholar(2) HERMANN CR: Jour. Mich. Med. Soc., Jan. 1919. Google Scholar(3) FEDER JM: Jour. Lab. and Clin. Med., Feb. 1927. Google Scholar(4) DOBELLO'CONNOR CFW: Intestinal Protozoa of Man. Google Scholar(5) BOYERS LM: Jour. Am. Med. Asso., Nov. 7, 1925. MedlineGoogle Scholar(6) RUNYANHERRICK RWAB: Am. Jour. Trop. Med., March, 1925. Google Scholar(7) VALLARINO JJ: Am. Jour. Trop. Med., March, 1925. Google Scholar(8) COUNCILMANLAFLEUR WTH: Johns Hopkins Hosp. Rep., 1891, Vol. ii, p. 393. Google Scholar(9) SANDWITH FM: Lancet, Sept. 19, 1914. Google Scholar(10) HARRIS HF: Am. Jour. Med. Sc., 1898, i. Google Scholar(11) ROGERS L: Brit. Med. Jour., 1903, i, p. 1316. Google Scholar(12) JAMESDEEKS WMWE: Am. Jour. Trop. Med., March, 1925. Google Scholar(13) CLARK HC: Am. Jour. Trop. Med., March, 1925. Google Scholar(14) COATESGROVES VEW: Brit. Jour. of Surg., 1927, No. 55. CrossrefGoogle Scholar(15) WILLIAMSONKAPLANGEIGER CSBJC: Jour. Am. Med. Assn. Feb. 16, 1929. Google Scholar(16) COLEHEIDEMAN WHML: Jour. Am. Med. Assn. Feb. 16, 1929. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Montreal, Canada*From the Pathological Laboratories of the University of Michigan, Ann Arbor, Michigan. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byAMEBOMA OF THE INTESTINE: AN ANALYSIS OF THE DISEASE AS PRESENTED IN 78 COLLECTED AND 41 PREVIOUSLY UNREPORTED CASES*RYLE A. RADKEAmebic GranulomaAmebiasisCommon features of chronic amoebic colitisAmebic granuloma of the rectum and balantidiasis in the same patient 1 April 1929Volume 2, Issue 10Page: 1081-1091KeywordsAmebiasisDysentery ePublished: 1 December 2008 Issue Published: 1 April 1929 PDF downloadLoading ...
Abstract 12192: MBNL1 Directly Regulates the Alternative Splicing of mRNAs That Promote Myofibroblast Differentiation
Authors: Jennifer Davis, Michelle Sargent, Jianjian Shi, Lei Wei, Maurice S Swanson, Jeffery D Molkentin
Journal: Circulation (2014)

Rationale: During the cardiac injury response fibroblasts differentiate into myofibroblasts, a cell type that enhances extracellular matrix production and facilitates ventricular remodeling. To better understand the molecular mechanisms whereby myofibroblasts are generated in the heart we performed a genome-wide screen with 18,000 cDNAs, which identified the RNA-binding protein muscleblind-like splicing regulator 1 (MBNL1), suggesting a novel association between mRNA alternative splicing and the regulation of myofibroblast differentiation. Objective: To determine the mechanism whereby MBNL1 regulates myofibroblast differentiation and the cardiac fibrotic response. Methods and Results: Confirming the results from our genome wide screen, adenoviral-mediated overexpression of MBNL1 promoted transformation of rat cardiac fibroblasts and mouse embryonic fibroblasts (MEFs) into myofibroblasts, similar to the level of conversion obtained by the profibrotic agonist transforming growth factor β (TGFβ). Antithetically, Mbnl1 -/- MEFs were refractory to TGFβ-induced myofibroblast differentiation. MBNL1 expression is induced in transforming fibroblasts in response to TGFβ and angiotensin II. These results were extended in vivo by analysis of dermal wound healing, a process dependent on myofibroblast differentiation and their proper activity. By day 6 control mice had achieved 82% skin wound closure compared with only 40% in Mbnl1 -/- mice. Moreover, Mbnl1 -/- mice had reduced survival following myocardial infarction injury due to defective fibrotic scar formation and healing. High throughput RNA sequencing (RNAseq) and RNA immunoprecipitation revealed that MBNL1 directly regulates the alternative splicing of transcripts for myofibroblast signaling factors and cytoskeletal-assembly elements. Functional analysis of these factors as mediators of MBNL1 activity is also described here. Conclusions: Collectively, our data suggest that MBNL1 coordinates myofibroblast transformation by directly mediating the alternative splicing of an array of mRNAs encoding differentiation-specific signaling transcripts, which then alter the fibroblast proteome for myofibroblast structure and function.
Voices of Reason, Voices of Insanity: Studies of Verbal Hallucinations
Authors: David Ames
Journal: BMJ (2000)

Ivan Leudar, Philip Thomas 

Brunner-Routledge, £15.99, pp 240 ISBN 0 415 14787 5

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When I began training in psychiatry in 1982 I was taught that the form of patients' unusual experiences was usually more important than the content when making a psychiatric diagnosis. Despite this, one patient sticks in my mind.

This man had shot himself in the roof of the mouth in an attempt to rid himself of chastising voices which he thought came from the head of his late wife's doctor attached to his shoulder. It seemed to me that the content of these experiences might have been important in determining his behaviour.

Leudar and Thomas would have sympathised with my …

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Clonal Deletion Prunes but Does Not Eliminate Self-Specific αβ CD8+ T Lymphocytes
Authors: Wong Yu, Ning Jiang, Peter J.R. Ebert, Brian A. Kidd, Sabina Müller, Peder J. Lund, Jeremy Juang, Keishi Adachi, Tiffany Tse, Michael E. Birnbaum, Evan W. Newell, Darrell M. Wilson, Gijsbert M. Grotenbreg, Salvatore Valitutti, Stephen R. Quake, Mark M. Davis
Journal: Immunity (2015)