tbuckley/cabot-search huggingface dataset:
Abstract 3729: Scavenger Receptor Bi (sr-bi)-mediated Selective Uptake Is Required For The Remodelling Of Hdl By Endothelial Lipase
Authors: Niels Nijstad, Harmen Wiersma, Thomas Gautier, Markus van der Giet, Cyrille Maugeais, Uwe Tietge
Journal: Circulation (2008)

Objectives Endothelial lipase (EL) is a negative regulator of HDL cholesterol plasma levels, and scavenger receptor BI (SR-BI) is involved in remodelling of HDL. The present study investigates the requirement of SR-BI for the effects of EL-mediated phospholipid hydrolysis on HDL metabolism in vivo . Methods and Results In vitro , selective uptake from EL-modified HDL was 129 % higher than selective uptake from control HDL in SR-BI overexpressing cells (p=0.01). In vivo overexpression of human EL by means of recombinant adenovirus decreased HDL plasma levels significantly (p&lt;0.01). FPLC analysis and non-denaturing gel electrophoresis revealed that EL expression resulted in the generation of small HDL particles in wild-type mice, while in SR-BI −/− mice small HDL were preferentially removed. In kinetic experiments the fractional catabolic rate (FCR) of HDL cholesteryl ester (CE) increased by 110% (p&lt;0.001) and the FCR of HDL apolipoproteins by 64% (p&lt;0.001) in response to EL overexpression in wild-type mice. In SR-BI −/− mice a similar increase in the HDL apolipoprotein FCR occurred (p&lt;0.001), however, no further increase in HDL CE catabolism. The apparent whole body selective uptake was increased 3-fold by EL in wild-type mice (p&lt;0.001), while there was no selective uptake in SR-BI ko mice. EL overexpression increased hepatic selective uptake as well as holoparticle uptake (each p&lt;0.01) in wild-type mice, while in SR-BI ko mice only holoparticle uptake increased (p&lt;0.01). Conclusions Our results indicate that SR-BI-mediated selective uptake of HDL cholesteryl ester is essential for the remodelling of large alpha-migrating HDL particles by EL.
NIH Eases Ethics Rules on Employees
Authors: Tracy Hampton
Journal: JAMA (2005)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Preliminary Report of a Multicenter Prospective Phase II Study of DA-EPOCH-R in MYC-Rearranged Aggressive B-Cell Lymphoma
Authors: Kieron Dunleavy, Michelle Fanale, Ann LaCasce, Ariela Noy, Paolo Caimi, Samir Parekh, John W Hayslip, Deepa Jagadeesh, Raymond S Lord, Mary J Lechowicz, Rakesh Gaur, Andrea Lucas, Louis M Staudt, Seth M. Steinberg, Brad Kahl, Jonathan W. Friedberg, Richard F Little, Nancy L Bartlett, Wyndham H Wilson
Journal: Blood (2014)
Abstract 2360: Central Sleep Apnea with Nocturnal Hypoxia Promotes Increased Circulating Erythropoietin in Heart Failure
Authors: Andrew D Calvin, Virend K Somers, Jennifer M Miller, David P Steensma, Lyle J Olson
Journal: Circulation (2008)

Central sleep apnea (CSA) with nocturnal hypoxia is frequent in heart failure (HF). Hypoxia causes increased circulating erythropoietin (EPO) in healthy normals. EPO promotes increased vasoconstriction and exogenous EPO administration is associated with adverse cardiovascular events. No prior studies have related EPO concentration to apnea or hypoxia due to CSA. EPO is elevated in HF patients with nocturnal hypoxia due to CSA. Ambulatory, non-anemic HF patients (n = 29) with LVEF &lt; 45% and healthy controls (n = 18) underwent polysomnography (PSG). Subjects with obstructive sleep apnea (OSA) were excluded. CSA was defined as apnea-hypopnea index (AHI) ≥ 15. Hypoxia was quantified as the proportion of sleep with arterial oxygen saturation &lt; 90% (T90%). Blood for EPO was drawn post-PSG. Other clinical characteristics were summarized from the medical record. HF subjects and controls were similar age (54 vs 60 y, p = 0.09). CSA was present in 14 HF subjects; 13 were men compared to 8 of 15 without CSA (p = 0.04). HF subjects had 42% higher mean EPO than controls (p &lt; 0.01) despite similar hemoglobin (13.9 vs 14.0 g/dL, p = 0.8). NYHA class III–IV HF subjects had 42% higher mean EPO than class I–II HF subjects (p = 0.05, figure ). EPO concentration was correlated with severity of nocturnal hypoxia by simple linear regression (r = 0.4; p = 0.02). By multivariate analysis, elevated EPO was associated with NYHA class III–IV HF and elevated AHI (p = 0.01 and 0.03, respectively; r = 0.6) after adjusting for age, gender, LVEF, renal function and hemoglobin. Nocturnal hypoxia due to CSA promotes increased endogenous EPO concentration in HF patients.
Abstract 16157: Risk Factors for Interstage Death After the Norwood Procedure
Authors: Laura Taylor, Jennifer Hirsch, James Gurney, Janet Donohue, Richard G Ohye, Karen King, Caren Goldberg
Journal: Circulation (2010)

Objective: Interstage death (ISD) remains a significant risk for patients (pts) with hypoplastic left heart syndrome (HLHS). Risk factors for ISD remain largely unknown. The purpose of this study w...
Outcome of Patients &amp;gt; Age 40 with Burkitt Lymphoma (BL) Treated with Aggressive Chemotherapuetic Regimens: Results from the International Burkitt Lymphoma Collaborative Group.
Authors: Jonathan W. Friedberg, Lauren Ciminello, Jennifer Kelly, Simon Clawson, Dieter Hoelzer, Harald Holte, Ann S. LaCasce, Graham Mead, Deborah Thomas, Gustaaf W. van Imhoff, Bruce Cheson, Ian T. Magrath, Richard I. Fisher
Journal: Blood (2005)
Screening for Breast Cancer: Systematic Evidence Review Update for the US Preventive Services Task Force
Authors: Heidi D Nelson, Kari Tyne, Arpana Naik, Christina Bougatsos, Benjamin Chan, Peggy Nygren, Linda Humphrey
Journal: Annals of Internal Medicine (2009)

Background
This systematic review is an update of evidence since the 2002 U.S. Preventive Services Task Force (USPSTF) recommendation on breast cancer screening.
Abstract 13538: Relaxin Mitigates a Substrate for Atrial Fibrillation in Spontaneously Hypertensive Rats
Authors: Ashish A Parikh, Divyang R Patel, Wenyu Xiang, Jamie Haney, Charles F McTiernan, Sanjeev G Shroff, David Schwartzman, Guy Salama
Journal: Circulation (2012)

Atrial Fibrillation (AF), the most common arrhythmia, contributes significantly to morbidity and mortality. AF has been associated with hypertension, aging, and fibrosis. Studies have shown that Sp...
Psychiatric emergencies: an overview
Authors: S Gerson, E Bassuk
Journal: American Journal of Psychiatry (1980)

The psychiatric emergency ward has become a primary entry point into the network of mental health services for people who need help to cope with their problems of living. It is also the only source of treatment for many chronically mentally ill patients living in the community. The authors critically review the literature on emergency psychiatric services, focusing on the ways these services are used, the atmosphere in the emergency room, and the determinants of disposition decision making. On the basis of their research, they suggest a model for emergency services that includes an evaluation of the patient's and his on her community's resources and competence and minimizes subtle diagnostic considerations.
Postanal Repair for Faecal Incontinence
Authors: M R B Keighley
Journal: Journal of the Royal Society of Medicine (1984)

Between 1977 and 1983, 105 patients had a postanal repair for the treatment of faecal incontinence. All except 8 patients were women. The principal reasons for operation were: persistent incontinence after rectopexy (n = 25), obstetric trauma (n = 18), anal dilatation (n = 12) and pelvic floor neuropathy (n = 41). One patient died after operation. Of 89 patients followed up for at least six months after operation, 56 (63%) have complete control of faeces and flatus, but 19 have control of solid faeces only and 14 are no better. The poor results were associated with wound sepsis and previous operations particularly in men.
Effects of amantadine and trihexyphenidyl on memory in elderly normal volunteers
Authors: J. P. McEvoy, M. McCue, B. Spring, R. C. Mohs, P. W. Lavori, R. M. Farr
Journal: American Journal of Psychiatry (1987)

Anticholinergic drugs impair one's ability to learn new material, even at routine clinically used doses. During the trihexyphenidyl phase of this double-blind crossover trial, elderly normal subjects complained of confusion and memory impairment and demonstrated a pattern of deficits in memory function compatible with that previously reported to result from anticholinergic drugs. The subjects neither complained of nor demonstrated memory impairment while taking amantadine, which is believed to exert its pharmacological effects upon extrapyramidal disorders via dopaminergic mechanisms and does not appear to be associated with memory impairment. Anticholinergic drugs should be avoided whenever possible in the elderly and especially in those suffering dementia.
Anorexia nervosa and affective disorders: a controlled family history study
Authors: Timothy M Rivinus, Joseph Biederman, David B. Herzog, Karen Kemper, Gordon P. Harper, Jerold S. Harmatz, Steve Houseworth
Journal: American Journal of Psychiatry (1984)

Analysis of family history information from a prospectively studied group of 40 young female patients with anorexia nervosa and 23 normal control female subjects of similar age showed more depression and substance use disorders in first- and second-degree relatives of anorexia nervosa patients. Further, the pedigrees of the patients differed significantly from those of the control subjects in the higher frequency of depression and substance use disorders in consecutive generations and in the family "loading" of these disorders. These findings, consistent with previous reports, add to the growing evidence of an association between anorexia nervosa and familial risk for affective and related disorders.
Impact of Plaque Composition on Cardiac Troponin Elevation After Percutaneous Coronary Intervention
Authors: Young Joon Hong, Gary S. Mintz, Sang Wook Kim, Sung Yun Lee, Teruo Okabe, Augusto D. Pichard, Lowell F. Satler, Ron Waksman, Kenneth M. Kent, William O. Suddath, Neil J. Weissman
Journal: JACC. Cardiovascular imaging (2009)
Breast Cancer Incidence and Mortality in the Breast Cancer Detection Demonstration Project
Authors: A. S. Morrison, J. Brisson, N. Khalid
Journal: JNCI Journal of the National Cancer Institute (1988)

The Breast Cancer Detection Demonstration Project (BCDDP) was a program of five annual screening examinations for breast cancer that was conducted at 29 centers in the United States. This report presents data on breast cancer Incidence and mortality among the participants. A total of 283,222 women were enrolled. Our analysis is based on 55,053 white women who were 35–74 years of age at entry and who were selected for follow-up. For the first 9 years after entry, the cumulative incidence of breast cancer was estimated as 243.6 per 10,000, which is 1.34 times the expected incidence derived by use of data from the Surveillance, Epidemiology, and End Results (SEER) program. In contrast, 9-year cumulative mortality from breast cancer was only 79.6% of that expected in women with the age distribution of BCDDP participants who did not have diagnosed breast cancer at the start of observation. The ratio of observed to expected breast cancer mortality was 0.89 for women 35–49 years of age at entry, 0.76 for women 50–59 years of age at entry, and 0.74 for women 60–74 years of age at entry. Breast cancer incidence and mortality were lower for women who entered the BCDDP for routine screening than they were for women who entered for a reason such as concern about breast disease, family history of breast cancer, or a physician's recommendation. Among cases diagnosed within 5 years of entry, the 5-year case fatality attributed to breast cancer was 8.5%. Case fatality for all stages combined was >50% lower for cases that were screen-detected than it was for cases that were not screen-detected. Case fatality was lower for cases diagnosed within the fIrst 5 years of entry (which encompassed the period of screening) than it was for cases diagnosed in the sixth or seventh years. [J Natl Cancer Inst 1988;80:1540–1547]
A Cytosieye Permitting Sterile Preparation of Suspensions of Tumor Cells for Transplantation&lt;xref ref-type="fn" rid="fn1"&gt;&lt;sup&gt;2&lt;/sup&gt;&lt;/xref&gt;
Authors: George D. Snell
Journal: JNCI Journal of the National Cancer Institute (1953)

A Cytosieye Permitting Sterile Preparation of Suspensions of Tumor Cells for Transplantation Get access George D. Snell George D. Snell Roscoe B. Jackson Memorial Laboratory, Bar Harbor, Maine Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 13, Issue 6, June 1953, Pages 1511–1515, https://doi.org/10.1093/jnci/13.6.1511 Published: 01 June 1953 Article history Received: 06 March 1953 Published: 01 June 1953
Abstract 369: Utility of Stress Echocardiography for Predicting Perioperative Cardiac Outcomes Among Patients Undergoing Liver Transplant Surgery
Authors: Anas Safadi, Kathleen A Lane, Stephen G Sawada, Jo Mahenthiran
Journal: Circulation (2009)

Background: Stress echocardiography (SE) is used in patients undergoing liver transplant surgery (LTS) for perioperative cardiac event risk assessment. However, the utility of this test for underlying coronary disease remains less well established and controversial in prior publications. Hence, we sought to evaluate this among patients who underwent SE and subsequently LTS. Methods: Patients who had LTS between 2001– 2005 were studied. The three outcomes analyzed were the occurrence of non-fatal myocardial infarction (MI), death or either outcome over a follow up period of 30 days following LTS. Stepwise logistic regression was used to identify variables associated with cardiac outcomes. Salient variables of clinical demographics, cardiac medications, EKG findings, and postoperative complications were included in the analysis of LTS patients who underwent preoperative dobutamine SE. Results: Of 356 patients (mean age 51±9 years, 65% male), 89 (25%) were diabetic, 74 (21%) hypertensive and 150 (42%) had hi...
Abstract 16447: Bipolar Electrogram Signatures of Therapeutic Interest During Human Ventricular Fibrillation
Authors: Karthikeyan Umapathy, Joyce Jeyaratnam, Ahmed Niri, Stephane Masse, Talha Farid, Krishnakumar Nair, Robert J Cusimano, Kumaraswamy Nanthakumar
Journal: Circulation (2011)
Psychosis and physical aggression in probable Alzheimer's disease
Authors: Lynn H. Deutsch, Frederick W. Bylsma, Barry W. Rovner, Cynthia Steele, Marshall F. Folstein
Journal: American Journal of Psychiatry (1991)

The purpose of this study was to determine the frequency and type of psychotic symptoms in patients with probable Alzheimer's disease and to test whether there is a relationship between specific psychotic symptoms and episodes of physical aggression.From 209 patients with possible or probable Alzheimer's disease who had been assessed in a research clinic every 6 months for up to 4.5 years, 181 subjects with probable Alzheimer's disease were selected for study. On the basis of the summary note for each visit in the patients' charts, the presence of delusions, hallucinations, misidentifications, and episodes of physical aggression was determined. Data regarding psychotic symptoms and aggression were available for 170 and 169 subjects, respectively.Delusions had been reported for 74 (43.5%) of the patients and were the most frequent psychotic symptom; persecutory delusions were the most common type. Physical aggression had been noted for 50 (29.6%) of the patients. Delusions and misidentifications frequently preceded and were significantly associated with episodes of physical aggression. The presence of delusions was a significant predictor of physical aggression but accounted for only 3.5% of the variance.This study suggests that delusions are a risk factor for physical aggression in patients with probable Alzheimer's disease who have moderate to severe cognitive impairment. As delusions accounted for only a small percentage of the variance, further research is needed to identify other variables that may be significant predictors of physical aggression in this population.
Abstract 17812: Race is Not Associated with Contrast-Induced Nephropathy but is Associated with Long-Term Initiation of Dialysis After Cardiac Catheterization and Coronary Intervention
Authors: Jeremy Turlington, Peter Danyi, Kalpesh Patel, Manishkumar Patel, Ion S Jovin
Journal: Circulation (2011)

Background: Contrast-induced nephropathy (CIN) is a complication of diagnostic angiography and percutaneous coronary and endovascular intervention. It is associated with diabetes and chronic kidney disease, both diseases which are associated with poorer outcomes in non-Caucasians. We investigated the effect of race in the development of CIN . Methods and Results: We studied 2201 predominantly (98%) male patients undergoing peripheral and coronary angiography and percutaneous coronary and endovascular intervention at a veterans’ administration medical center. We analyzed the incidence of CIN at 72 hours, of renal dysfunction at 3 months as well as the incidence of hemodialysis. CIN was defined as either a rise in creatinine of 25% or an absolute rise in creatinine of 0.5 mg/dl. The mean age was 68.2 years. The Caucasian patients (n=1446) were significantly older, had a lower baseline creatinine, lower rates of hypertension and diabetes compared to the non-Caucasian patients. Information on creatinine at 3 days was available on 1062 patients and on creatinine at 3 months on 1937 patients. CIN occurred in 56 (7.9%) Caucasian patients (n=711 patients) and in 31 (8.8%) non-Caucasians at 72 hours after the procedure (odds ratio [OR] 0.76; 95% confidence interval [CI] 0.42 - 1.37; P=0.36). At 3 months, renal dysfunction was seen in 77 (15.04%) Caucasian patients (n=512) versus 49 (16.72%) of the non-Caucasian group (OR 0.88, CI 0.60 - 1.30; P=0.53). On multivariate analysis, after adjustment for age, comorbidities and baseline creatinine, Caucasian race was not significantly associated with CIN at 72 hours (OR=0.94, 95% CI 0.40 - 2.33, P=0.89) or with renal dysfunction at 3 months (OR= 1.2, 95% CI 0.78 - 2.0, P=0.35). After a median follow up of 67 months, of the 2201 patients 12 patients (0.8 %) of the Caucasian group were placed on dialysis versus 26 (3.4 %) of the non-Caucasian group (HR 0.20, CI 0.08 - 0.47; P&lt;0.0001). Conclusions: In this cohort of patients, race was not associated with the development of CIN at 72 hours, or the development of renal dysfunction at 3 months post procedure. In the long-term, the rate of initiation of dialysis after was significantly higher in the non-Caucasian patients.
Abstract 1133: Association Between Baseline Plasma Renin Activity and Risk of Cardiovascular Events in Women With Coronary Artery Disease
Authors: Heidi T May, Tami L Bair, Jeffrey L Anderson, Margaret F Prescott, Benjamin D Horne, Joseph B Muhlestein
Journal: Circulation (2009)

More women than men in the United States die from coronary artery disease (CAD) each year. The predictive ability of plasma renin activity (PRA), a marker of renin-angiotensin-aldosterone system ac...
Efficacy, safety, and cost of new anticancer drugs
Authors: H. Calvert
Journal: BMJ (2002)

Emergency response to 999 calls Alternatives to the emergency 999 response can be seen in EuropeEditor-Snooks et al point out that the current 999 emergency response system has problems: increasing demand from the public and ever shorter response time targets. 1 They find a lack of evidence on alternative systems and responses in the English medical literature.By restricting their search, they overlook live examples only a few miles from these shores.France, since the mid-1960s, has had a system which incorporates many of the alternatives quoted by the authors: the Service d'Aide Medical Urgente (SAMU). 2 Calls to the control room are logged by trained telephone operators and then passed on to a "medical dispatcher": a doctor in emergency medicine, trained by the service.Medical dispatchers may simply provide medical advice to the caller, or they may decide to use one of a range of other responses to a call.These are referral to, or the dispatch of, a primary care doctor; arranging nonurgent transport by a private ambulance; urgent transport by pompiers (emergency technicians working through the fire service); or sending out a mobile intensive care unit with a doctor trained in emergency medicine.Medical dispatchers also coordinate the deployment of additional resources and decide on the most appropriate destination for a patient.In 2001 the service covering Paris received 300 000 calls (about 820 calls per day).Only 6% of the calls (50 per day) resulted in the dispatch of a mobile intensive care unit.In 16% of cases (130 per day) a primary care doctor was called.Altogether 205 calls per day were managed by the pompiers, by a private ambulance, or by giving medical advice.The remainder were