tbuckley/cabot-search huggingface dataset:
Prognostic Significance of Deep Vein Thrombosis in Patients Presenting with Acute Symptomatic Pulmonary Embolism
Authors: David Jiménez, Drahomir Aujesky, Gema Díaz, Manuel Monreal, Remedios Otero, David Martí, Elena Marín, Enrique Aracil, Antonio Sueiro, Roger D. Yusen
Journal: American Journal of Respiratory and Critical Care Medicine (2010)

Rationale: Concomitant deep vein thrombosis (DVT) in patients with acute pulmonary embolism (PE) has an uncertain prognostic significance.Objectives: In a cohort of patients with PE, this study compared the risk of death in those with and those without concomitant DVT.Methods: We conducted a prospective cohort study of outpatients diagnosed with a first episode of acute symptomatic PE. Patients underwent bilateral lower extremity venous compression ultrasonography to assess for concomitant DVT.Measurements and Main Results: The primary study outcome, all-cause mortality, and the secondary outcome of PE-specific mortality were assessed during the 3 months of follow-up after PE diagnosis. Multivariate Cox proportional hazards regression was done to adjust for significant covariates. Of 707 patients diagnosed with PE, 51.2% (362 of 707) had concomitant DVT and 10.9% (77 of 707) died during follow-up. Patients with concomitant DVT had an increased all-cause mortality (adjusted hazard ratio [HR], 2.05; 95% confidence interval [CI], 1.24 to 3.38; P = 0.005) and PE-specific mortality (adjusted HR, 4.25; 95% CI, 1.61 to 11.25; P = 0.04) compared with those without concomitant DVT. In an external validation cohort of 4,476 patients with acute PE enrolled in the international multicenter RIETE Registry, concomitant DVT remained a significant predictor of all-cause (adjusted HR, 1.66; 95% CI, 1.28 to 2.15; P < 0.001) and PE-specific mortality (adjusted HR, 2.01; 95% CI, 1.18 to 3.44; P = 0.01).Conclusions: In patients with a first episode of acute symptomatic PE, the presence of concomitant DVT is an independent predictor of death in the ensuing 3 months after diagnosis. Assessment of the thrombotic burden should assist with risk stratification of patients with acute PE.
The Future of Generalism in Medicine
Authors: Glenn S. Ross
Journal: Annals of Internal Medicine (2005)

Letters1 November 2005The Future of Generalism in MedicineGlenn S. Ross, MDGlenn S. Ross, MDFrom Newport News, VA 23606.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-143-9-200511010-00021 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:I was gratified to read the candid and incisive editorial by Larson and colleagues (1) regarding the future of generalism in medicine. With clarity rarely encountered in medical journals, the authors boldly validated what every practicing general internist already knows: Economic pressures pose the greatest threat to generalist medicine in the United States, and a permanent fix of the flawed reimbursement system is imperative to revitalize general internal medicine. With limited numbers of graduating medical students electing to pursue training programs in primary care fields, fewer graduating medical residents pursuing primary care careers, and increasing numbers of ...References1. Larson EB, Roberts KB, Grumbach K. Primary care, generalism, public good: déjà vu? Again! [Editorial]. Ann Intern Med. 2005;142:671-4. [PMID: 15838076] LinkGoogle Scholar2. Garibaldi RA, Popkave C, Bylsma W. Career plans for trainees in internal medicine residency programs. Acad Med. 2005;80:507-12. [PMID: 15851467] CrossrefMedlineGoogle Scholar Author, Article, and Disclosure InformationAffiliations: From Newport News, VA 23606.Disclosures: None disclosed. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoPrimary Care, Generalism, Public Good: Déjà vu? Again! Eric B. Larson , Kenneth B. Roberts , and Kevin Grumbach The Future of Generalism in Medicine C. Anderson Hedberg Metrics Cited byFactors associated with the subspecialty choices of internal medicine residents in Canada 1 November 2005Volume 143, Issue 9Page: 693KeywordsConflicts of interestFearForecastingHospitalistsNurses ePublished: 1 November 2005 Issue Published: 1 November 2005 Copyright & PermissionsCopyright © 2005 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
The Search for Erythropoietin
Authors: Allan J. Erslev
Journal: New England Journal of Medicine (1971)

Studies of the regulation of red-cell production have recently taken on some urgency because of the potential usefulness of erythropoietin in the treatment of patients with anemia due to chronic renal disease. For such treatment, far greater amounts of erythropoietin will be needed than can be supplied from serum and urine, and it is necessary to go to the source of production to meet the demand. Since the classic study by Jacobson and his co-workers in 1957,1 it has generally been accepted that the source of production must be the kidney. The kidney is assumed to have a dual erythropoietic . . .
SELECTIVE BLOCKADE OF A2B ADENOSINE RECEPTOR REDUCES CARDIAC REMODELING FOLLOWING ACUTE MYOCARDIAL INFARCTION IN THE MOUSE
Authors: Stefano Toldo, Eleonora Mezzaroma, Benjamin Van Tassell, Harsha Kannan, Hongyan Zhong, Dewan Zeng, Luiz Belardinelli, Norbert Voelkel, Antonio Abbate
Journal: Journal of the American College of Cardiology (2012)
Correlation of Ballistocardiogram with Work Performance and Energy Cost for Guidance in Rehabilitation of Cardiac Patients
Authors: HENRY BROWN, SEYMOUR H. RINZLER, JOSEPH G. BENTON
Journal: Circulation (1953)

Correlative studies of the resting ballistocardiogram and the ability to expend energy in cardiac patients indicate that the resting ballistocardiogram may be a useful tool in evaluating the functional or work capacity of a cardiac patient for rehabilitation purposes and vocational guidance, and may serve as a screening device for finding those cardiacs, other things being equal, who possess the functional capacity to perform jobs or activities whose energy requirements are known or can be estimated. However, in view of the relatively higher incidence of abnormal resting ballistocardiograms in the older age groups, for practical purposes, this usefulness of the ballistocardiogram may be limited to the cardiac patient under the age of 50.
Potassium Depletion and Alkalosis
Authors: James B. Wyngaarden, Hans G. Keitel, Kurt Isselbacher
Journal: New England Journal of Medicine (1954)

Excessive potassium loss in the urine of patients with renal insufficiency is usually associated with acidosis and inability to conserve fixed cations. This report concerns a patient with malignant nephrosclerosis and a renal disorder of potassium conservation associated with alkalosis.Case Report¶J.M. (M.G.H. U-755166), a 46-year-old Italian tile layer, entered the hospital on October 17, 1951, because of weakness, weight loss and hematuria. For seventeen years he had had intermittent headaches. Sixteen years before entry he had an attack of ureteral colic and passed a renal stone. Twelve years later the blood pressure was 170/120, and the urine was . . .
Pulmonary aspergillomata in a child treated with clotrimazole.
Authors: E G Evans, D A Watson, N R Matthews
Journal: BMJ (1971)

spheroidal and polyhedral malignant cells displaying pronounced pleomorphism and numerous mitotic figures.Initially a diagnosis of Hodgkin's disease was considered, but on review it was decided that the appearances indicated an anaplastic secondary carcinoma compatible with a metastasis from a primary breast neoplasm.Because of the absence of a palpable mass in the breast and in view of the patient's age it was decided that immediate mastectomy was not indicated.The right axilla and supraclavicular region were treated by radiotherapy (1,400 rads) but the breast itself was not irradiated.The patient was kept under regular observation.She remained well until 1966, when a small mobile swelling was noted in the left breapt.Mammography showed no abnormality in either breast.The lump was excised and on histological examination it was seen to be an area of fibroadenosis with no evidence of malignancy.She continued to be examined regularly in the breast unit.No masses were palpable in either breast until December 1970, when a discrete hard nodule 1-5 cm in diameter was noted in the upper outer quadrant of the right breast.This was tethered slightly to skin but not to muscle.Axillary lymph nodes were not enlarged and there were no other abnormalities on examination.Chest x-ray film and skeletal survey showed no metastases.A carcinoma, with microcalcification, however, was found in the right breast on mammography.The mass was excised.Frozen-section histological examination showed a carcinoma 2 cm in diameter.A radical mastectomy was then done.Histological examination showed a poorly differentiated intraduct and infiltrating carcinoma.Several axillary lymph nodes contained metastatic tumour deposits.
EXPERIMENTAL ASPECT OF FIXED ERUPTION DUE TO ALURATE, A COMPOUND OF ALLONAL
Authors: ADOLPH B. LOVEMAN
Journal: JAMA (1934)

In 1903, Fischer and von Mering 1 described the barbituric acid hypnotic diethylbarbituric acid (diethyl malonyl urea), introduced as Veronal. This is now official in the United States Pharmacopeia X as barbital. There were also introduced the sodium salts of barbital under the proprietary names Medinal and Veronal Sodium. Some years later a second derivative of the series was announced; in this, one of the ethyl groups was displaced by a phenyl group. This derivative, phenylethylbarbituric acid, was the proprietary designated as Luminal; the same substance is now official under the name phenobarbital.  In the meantime, numerous hypnotics of the barbituric acid series 2 in which the ethyl groups are replaced by other alkyl or aryl radicals have been developed, including, among the more common ones, amytal (isoamylethylbarbituric acid), dial (diallylbarbituric acid), neonal (N-butylethylbarbituric acid), nostal (isopropyl bromallyl barbituric acid) and pentobarbital sodium.  In February, 1922, Allonal (Numal) was introduced
Did ancestral humans dream for their lives?
Authors: Antti Revonsuo
Journal: Behavioral and Brain Sciences (2000)

The most challenging objections to the Threat Simulation Theory (TST) of the function of dreaming include such issues as whether the competing Random Activation Theory can explain dreaming, whether TST can accommodate the apparently dysfunctional nature of post-traumatic nightmares, whether dreams are too bizarre and disorganized to constitute proper simulations, and whether dream recall is too biased to reveal the true nature of dreams. I show how these and many other objections can be accommodated by TST, and how several lines of new supporting evidence are provided by the commentators. Accordingly TST offers a promising new approach to the function of dreaming, covering a wide range of evidence and theoretically integrating psychological and biological levels of explanation.
Death and Cremation Certificates
Authors: J. H. E. Moore
Journal: BMJ (1964)

BrITISH 1317 prepared by heating ox red cells at 100' C. for an hour.This accentuates the possibility that the perfusion technique used in openheart surgery might contribute to the infec- tious-mononucleosis syndrome.A further observation I made' was that there appeared to be a quantitative association between certain of the abnormal cells and the level of the heterophile-antibody titre.The following Table ' shows this in detail.The " large mononuclears " counted are probably aberrant tissue cells released by acute focal hyperplasia from the lymphatic reticulum.They are larger than and usually easily dis- tinguished from monocytes.They " smear"' readily and are liable to disappear in a few days." Virocytes " and Downey types other than type III seem unrelated to the presence of antibodies.Average No. of Serological No. of Large Classification Cases Mononuclears per c.mm. High positive (over 1 in 200) 25 2,366 Positive (1 in 30 to 1 in 200) 28 748Low positive (under 1 in 30) 20 669Negative .
The Role of Leptin in Human Obesity and Disease: A Review of Current Evidence
Authors: Christos S. Mantzoros
Journal: Annals of Internal Medicine (1999)

Purpose: To review recent advances in the pathophysiology and potential clinical applications of leptin, an adipose tissue-derived hormone. Data Sources: A MEDLINE search of the literature on leptin and the bibliographies of relevant papers. Study Selection: All 1320 publications on leptin. Data Extraction: All identified articles were reviewed. Cited publications were selected on the basis of study quality and relevance to human obesity and disease. Data Synthesis: Leptin is a 16-kilodalton adipocyte-derived hormone that circulates in the serum in the free and bound form. Serum levels of leptin reflect the amount of energy stored in adipose tissue. Short-term energy imbalance as well as serum levels of several cytokines and hormones influence circulating leptin levels. Leptin acts by binding to specific receptors in the hypothalamus to alter the expression of several neuropeptides that regulate neuroendocrine function and energy intake and expenditure. Thus, leptin plays an important role in the pathogenesis of obesity and eating disorders and is thought to mediate the neuroendocrine response to food deprivation. Phase I and II trials recently showed that leptin administration to humans is safe, and ongoing phase III trials are assessing the efficacy of leptin as a treatment for obesity and related disorders. Availability of leptin or smaller and more soluble leptin analogues for clinical studies in humans is expected to significantly advance understanding of the mechanisms underlying energy homeostasis in humans. Conclusions: Leptin is significantly broadening our understanding of the mechanisms underlying neuroendocrine function, body weight, and energy homeostasis. Elucidation of these mechanisms is expected to result in the development of novel therapeutic approaches for obesity and eating disorders.
Senate's Reform Package Wrapped Up in Time for Christmas
Authors: John K. Iglehart
Journal: New England Journal of Medicine (2009)

With no votes to spare — because every Republican stood in opposition — the normally fractious Senate Democrats cast aside their differences to pass a landmark health care reform bill by a vote of 60 to 39 on Christmas Eve, the 25th straight day of debate over the measure. The Congressional Budget Office (CBO) estimated the bill's cost at $871 billion over 10 years — divided among public subsidies to help lower-income people pay for private insurance, expansions of Medicaid and the Children's Health Insurance Program, and tax credits for small businesses. The measure would provide coverage to about 31 . . .
Radiation Hazards Control in Survival Operations in Event of Nuclear War
Authors: W G STEWART
Journal: JAMA (1963)

The concepts of radiation protection in survival operations are explained, and procedures devised to control radiation hazards for the protection of the population and maintenance of the operating efficiency of survival operations personnel are presented.Radiation protection is a command function. The medical responsibility is to provide advice on the probable effects of radiation exposure in the light of existing knowledge of these effects in man.The major hazard is that of external exposure to penetrating gamma radiation. Radiation exposure guides indicate that persons may be exposed to not more than 100 r whole body radiation in a six-week period, or 200 r whole body radiation in a period in excess of six weeks, without loss of operational efficiency. Beta radiation from fallout deposited on skin or clothing may produce burns, but these injuries will not be incapacitating and can be controlled by simple procedures.The internal hazard is mainly from ingestion of food or water contaminated with radioactive material. For protection, only canned or packaged foods and water from covered or deep wells are consumed during the early days after a nuclear attack.
USE OF DIAPHORESIS AND DIAPHORETIC AGENTS IN OPHTHALMIC THERAPEUTICS.
Authors: HIRAM WOODS
Journal: JAMA (1904)

To properly estimate the therapeutic value of an agent, allowance must be made for the natural enthusiasm of those who introduce it and who often record results which later experience fails to confirm, and the tendency of certain things to remedy themselves, the exciting cause having been removed. Disappointment may ensue because too much is expected. Credit may be given when none is due. Truth lies between these extremes, and is to be reached, it seems to me, by finding out what one should look for, basing judgment on the physiologic effects of the remedy, and the teachings of clinical experience. An example of what one may, not illogically, term therapeutic enthusiasm and therapeutic chaos, is found in the statements of books on general therapeutics and those on eye diseases, regarding the use of diaphoretic agents in ocular affections. If we could accept, for instance, all of the following from
Elevated F-18 FDG Uptake in Plasmacyte-Rich Chronic Maxillary Sinusitis
Authors: SEIEI YASUDA, AKIRA SHOHTSU, MICHIRU IDE, SHIGEHARU TAKAGI, HIROSHI KIJIMA, MASATOSHI HORIUCHI
Journal: Clinical Nuclear Medicine (1998)

Presented is a patient who had a benign lesion with elevated F-18 FDG uptake. A 58-year-old man underwent whole-body PET. High FDG uptake was noticed in his right maxilla. MRI demonstrated a soft tissue mass obstructing the right maxillary sinus. Laboratory tests, including leukocyte counts and C-reactive protein levels, were normal. Since the distinction between a neoplasm and inflammation was difficult, surgery was performed. During surgery, the mass was discovered to be fragile, and was easily removed. Pathology sections of the resected maxillary sinus mucosa demonstrated marked plasma cell infiltration in the edematous lamina propria mucosae. These plasma cells exhibited no cellular atypia, and no apparent formation of granulation tissue was found. Pathological diagnosis was chronic maxillary sinusitis. This case suggests that plasma cell-rich lesions may exhibit high glucose utilization, although the etiology of hypermetabolism in plasma cells remains unknown.
Detection of Early Onset of Hypophysitis by 18F-FDG PET-CT in a Patient With Advanced Stage Melanoma Treated With Ipilimumab
Authors: Bernies van der Hiel, Christian U. Blank, John B.A.G. Haanen, Marcel P.M. Stokkel
Journal: Clinical Nuclear Medicine (2013)

Ipilimumab is a human monoclonal antibody directed against a receptor expressed on activated T-lymphocytes (CTLA-4). Binding to this receptor induces T-cell activation against tumor cells. A 77-year-old man with a stage IV metastatic melanoma was treated with ipilimumab. F-FDG PET-CT performed for response evaluation revealed intense uptake in the pituitary gland. Two weeks later, biochemical parameters altered confirming hypophysitis. Treatment of the hypophysitis was started, and shortly thereafter, biochemical parameters normalized. Follow-up PET-CT revealed normalization of F-FDG uptake in the pituitary gland. In this case, we present a patient with ipilimumab-induced hypophysitis initially diagnosed on F-FDG PET-CT.
Renin and Hypertension: A Modern Synthesis
Authors: Leonard B. Berman
Journal: JAMA (1970)

Michael Lee has stated his purpose in the preface: to provide the general reader with an introduction to the subject of renin and its relation to blood pressure. He has succeeded admirably, with a clear, simple presentation abundantly documented. As befits an unsettled, growing topic, his tone is free from shrillness, dogmatism, and premature judgments. The book is well planned. The first section describes renin, its discovery, chemistry, and physiology. The section on renin measurement will not guide the reader through the confusing nomenclature, but Dr. Lee did not build this Tower of Babel. He would undoubtedly sign a petition to have it torn down. The second section concerns itself with renin and blood pressure. The presentation is well conceived, beginning with the role of renin in experimental hypertension and proceeding to clinical observations. The final chapter, a brief one entitled "A Modern Synthesis," represents a direct effort to make
OBSERVATIONS ON A NEW SPECIES OF EPIDERMO-PHYTON FOUND IN TINEA CRURIS
Authors: ALDO CASTELLANI
Journal: British Journal of Dermatology (1910)

Journal Article OBSERVATIONS ON A NEW SPECIES OF EPIDERMO‐PHYTON FOUND IN TINEA CRURIS Get access ALDO CASTELLANI, M.D. ALDO CASTELLANI, M.D. Professor of Tropical Medicine and Lecturer on Dermatology, Ceylon Medical College, Colombo Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 22, Issue 5, 1 May 1910, Pages 147–150, https://doi.org/10.1111/j.1365-2133.1910.tb16618.x Published: 01 May 1910
Multiple Chemical Hypersensitivities
Authors: Robert K. McLellan
Journal: Annals of Internal Medicine (1989)

Letters and Corrections1 December 1989Multiple Chemical HypersensitivitiesRobert K. McLellan, MD, MPHRobert K. McLellan, MD, MPHSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-111-11-953_1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the Editor:Considerable attention has recently been lavished on the practitioners of clinical ecology and their patients by the lay media, the legal community, and increasingly the medical specialties of allergy and occupational medicine. The recent publication (1, 2) of a position paper and editorial on the practices and theories of clinical ecology is in line with this increasing public concern. Although I agree with many of the specific criticisms of clinical ecology, I am deeply concerned that the thrust of the articles may lead the reader to dismiss the real problems of a group of patients along with...References1. . Clinical ecology. Ann Intern Med. 1989;111:168-78. LinkGoogle Scholar2. KahnLetz EG. Clinical ecology: environmental medicine or unsubstantiated theory. Ann Intern Med. 1989;111:104-5. LinkGoogle Scholar3. Cullen M. The worker with multiple chemical hypersensitivities: summary and directions for future investigators. State Art Rev Occup Med. 1987;2:801-4. MedlineGoogle Scholar4. HolmesKaplanGantz GJN. The chronic fatigue syndrome: a working case definition. Ann Intern Med. 1988;108:387-9. LinkGoogle Scholar5. SchottenfeldCullen RM. Recognition of occupation-induced post-traumatic stress disorders. J Occup Med. 1986;28:365. MedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Yale University School of Medicine New Haven, CT 06510 Center for Environmental Medicine Hamden, CT 06518 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByEnhanced Susceptibility to Environmental Chemicals 1 December 1989Volume 111, Issue 11Page: 953-953KeywordsAllergy and immunologyEcology Issue Published: 1 December 1989 PDF DownloadLoading ...
Localization of Friedreich ataxia phenotype with selective vitamin E deficiency to chromosome 8q by homozygosity mapping
Authors: C. Ben Hamida, N. Doerflinger, S. Belal, C. Linder, L. Reutenauer, C. Dib, G. Gyapay, A. Vignal, D. Le Paslier, D. Cohen, M. Pandolfo, V. Mokini, G. Novelli, F. Hentati, M. Ben Hamida, J.-L. Mandel, M. Kœnig
Journal: Nature Genetics (1993)