Angiotensin II, Digital Blood Flow, and the Precapillary and Postcapillary Blood Vessels of Man
Authors: N. P. DEPASQUALE
Journal: Annals of Internal Medicine (1963)

Article1 February 1963Angiotensin II, Digital Blood Flow, and the Precapillary and Postcapillary Blood Vessels of ManN. P. DEPASQUALE, M.D., G. E. BURCH, M.D., F.A.C.P.N. P. DEPASQUALE, M.D., G. E. BURCH, M.D., F.A.C.P.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-58-2-278 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptA number of polypeptides affect the smooth muscle of the blood vessels (1). Two such polypeptides, bradykinin and angiotensin, are released from the alpha-2-globulin of the plasma by enzymatic action (2, 3). Although both of these substances are polypeptides and both are released from the same plasma protein fraction, their actions on the blood vessels are quite different. A recent report from this laboratory described the digital vascular responses to intra-arterial injection of bradykinin as dependent in large part upon closure of the arteriovenous anastomoses (4). Since angiotensin has been considered by some to play an etiologic role in arterial...References1. SCHACHTER M: Polypeptides Which Affect Smooth Muscles and Blood Vessels, Pergamon Press, London, 1960. Google Scholar2. SKEGGS LT: Polypeptides of the renal pressor system, in Polypeptides Which Affect Smooth Muscles and Blood Vessels, Pergamon Press, London, 1960, p. 106. Google Scholar3. ROCHA E SILVABERALDOROSENFELD MWTG: Bradykinin, hypotensive and smooth muscle stimulating factor released from plasma globulin by snake venoms and by trypsin. Amer. J. Physiol. 156: 261, 1949. CrossrefMedlineGoogle Scholar4. BURCHDEPASQUALE GENP: Bradykinin, digital blood flow, and the arteriovenous anastomoses. Circulat. Res. 10: 105, 1962. CrossrefMedlineGoogle Scholar5. BURCHDEPASQUALE GENP: Effect of norepinephrine on the digital veins. Amer. Heart J. 60: 915, 1960. CrossrefMedlineGoogle Scholar6. BURCH GE: Digital rheoplethysmography. Circulation 13: 641, 1956. CrossrefMedlineGoogle Scholar7. BURCH GE: Rheoplethysmographic studies of digital venous tone and venous activity. J. Lab. Clin. Med. 55: 342, 1960. MedlineGoogle Scholar8. BURCH GE: Digital Plethysmography, Grune & Stratton, Inc., New York, 1954. Google Scholar9. BURCH GE: Digital pre- and postcapillary vasoconstriction and vasodilatation resembling pre- and postglomerular arteriolar function in kidney. Proc. Soc. Exp. Biol. Med. 102: 400, 1959. CrossrefMedlineGoogle Scholar10. BURCH GE: The rheoplethysmogram in man with aortic insufficiency. Arch. Intern. Med. 97: 644, 1956. CrossrefGoogle Scholar11. BURCHMURTADHA GEM: A study of the venomotor tone in a short intact venous segment of the forearm of man. Amer. Heart J. 51: 807, 1956. CrossrefMedlineGoogle Scholar12. BURCHDEPASQUALE GENP: The effect of angiotensin II on the venous system of man. Presented at the Seventh International Congress of Internal Medicine, Munich, September 5-8, 1962. Google Scholar13. FOLKOWJOHANSSONMELLANDER BBA: A comparison of the effects of noradrenalin and angiotensin on the resistance and the capacitance vessels in cats. Acta Physiol. Scand. supp. 175: 50, 1960. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: New Orleans, LouisianaPresented at the Forty-third Annual Session of the American College of Physicians, Philadelphia, Pennsylvania, April 9-13, 1962.Supported by grants from the United States Public Health Service.Requests for reprints should be addressed to G. E. Burch, M.D., Department of Medicine, Tulane University School of Medicine, New Orleans, Louisiana. 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