tbuckley/cabot-search huggingface dataset:
Skeletal Radiology: The Bare Bones
Authors: John R. Goetz
Journal: JAMA (1995)

ABSTRACT This is a unique videodisc containing nearly 2500 different images from over 650 cases largely collected from the Massachusetts General Hospital Bone and Joint Radiology Section teaching file and the skeletal radiology teaching file of the SUNY Health Science Center at Syracuse.The images are largely standard radiographs, although a few computed tomographic and magnetic resonance imaging scans are included. The radiology of musculoskeletal disease is covered in several sections including trauma, bone tumors, articular disease, congenital and developmental conditions, inflammatory bone disease, metabolic and endocrinologic bone disease, and post-surgical imaging. Also included is a self-evaluation series of images presented in the style of board examinations and a textbook-videodisc correlation with the author's earlier textbook Skeletal Radiology: The Bare Bones (Aspen Publishers, 1989). This textbook, along with a bar code manual, is included with the videodisc.The conceptual basis of skeletal radiology is covered in the accompanying texts by a
Thioridazine Hydrochloride in the Treatment of a Jaundiced Psychotic Patient
Authors: Herbert G. Aaronson
Journal: JAMA (1962)

THE PATIENT who has serious medical illness and is mentally disturbed poses interesting therapeutic problems. The urgency of management is the same whether the aberrant behavior is due to definable organic illness or to previously existent mental illness unmasked by the immediate somatic ills. Prompt control is mandatory for the safety of other patients, the patient himself, and those charged with his care.  A single psychotic patient can demoralize and disrupt the functioning of a ward of the average general hospital. This is especially true when there is tardiness in recognizing mental illness and no one is available who is familiar with handling disturbed patients. Despite progress in acquainting the public with the similarities between acute breaks in mental health and medical and surgical ills, the psychotic is still misunderstood and feared by those not familiar with this type of illness. Peace and usual routine are reestablished all too frequently
<i>Burkholderia cepacia</i> in Cystic Fibrosis
Authors: DESPINA DAISY FRANGOLIAS, ESHWAR MAHENTHIRALINGAM, SANDRA RAE, JANET M. RABOUD, A. G. F. DAVIDSON, RITA WITTMANN, PEARCE GEORGE WILCOX
Journal: American Journal of Respiratory and Critical Care Medicine (1999)

Variable clinical course has been reported with the acquisition of Burkholderia cepacia in patients who have cystic fibrosis (CF). We hypothesized that the perceived worsening with B. cepacia may reflect the underlying severity of pulmonary disease at the time of acquisition. To test this hypothesis, we matched CF patients colonized with B. cepacia with CF patients not colonized with the organism. Two-year pre- and postacquisition data and long-term data were compared. Patients were matched for gender, age ( ± 1 yr), height ( ± 5 cm), weight ( ± 8 kg), percent predicted forced expiratory volume in one second (% pred FEV1) ( ± 10%), and pancreatic sufficiency status. Differences in rates of change pre- and postacquisition for FEV1, FVC, weight, and frequency of intravenous courses were compared within pairs with the Wilcoxon signed rank test. Two-year and long-term survival was compared within pairs with the McNemar test. No significant differences were observed in mean annual rates of change in weight (0.33 and − 0.28 kg/yr), % pred FEV1 ( − 0.36 and − 1.74%/yr), and percent predicted forced vital capacity (% pred FVC) ( − 3.80 and − 2.32%/yr) between B. cepacia and control pairs in 2-yr and long-term postacquisition interval, respectively. Similar rates of change were noted for pre- to postacquisition intervals within pairs for weight (0.17 kg/yr), % pred FEV1 ( − 0.16%/yr), % pred FVC (5.02 %/yr). There was a significantly higher rate of intravenous antibiotic courses in B. cepacia cases in the 2-yr and long-term postacquisition interval. Higher mortality was observed in the B. cepacia cases in the long term (p < 0.05). We conclude that colonization with B. cepacia does not necessarily adversely affect pulmonary status, but is associated with reduced long term survival. Whereas previous associations may be attributed to a propensity to colonize those who had more advanced disease, specific strain types of B. cepacia may have enhanced pathogenicity. Frangolias DD, Mahenthiralingam E, Rae S, Raboud JM, Davidson AGF, Wittmann R, Wilcox PG. Burkholderia cepacia in cystic fibrosis: variable disease course.
Post-Traumatic Jaundice
Authors: Henry E. Marks
Journal: JAMA (1961)

<h3>To the Editor:—</h3> May I comment on the query concerning "post-traumatic jaundice" inThe Journal(<b>174:</b>1357 [Nov. 5] 1960) and the reply attributing the jaundice to possible laceration of the liver and absorption of extravasated bile. The circumstances described in the inquiry, that is, a mild injury (not specifically of the hepatic region) without immediately apparent consequences, jaundice appearing 2 weeks later, and "fibrosis" (obstruction?) of the common bile duct a week after that, could equally well be interpreted as hyperbilirubinemia due to absorption of blood from a traumatic hematoma, hemoperitoneum, or retroperitoneal hemorrhage. The jaundice may be due to a load of bilirubin exceeding excretory capacity, to obstruction of bile canaliculi by such an overload, or to intraductal bilirubin concretions, as seen in hemolytic anemia. In the absence of further data the "fibrosis of the common bile duct" might be interpreted as obstruction by such a concretion.
Detection of full fragile X mutation
Authors: R.G. Pergolizzi, S.H. Erster, P. Goonewardena, W.T. Brown
Journal: The Lancet (1992)

In fragile X syndrome, the most common inherited cause of mental deficiency, the underlying mutation is a large increase in the number of CGG repeats in a gene on chromosome X. We have developed a polymerase chain reaction (PCR) method to amplify across the full mutation in affected individuals. In this report, a fragile X family including a positive prenatally diagnosed fetus was analysed by PCR, and the results are consistent with direct genomic Southern blot analysis. Genetic screening of at-risk populations for fragile X can now be achieved by PCR rapidly, inexpensively, and on small samples.
Drug-resistant tuberculosis in Waltham Forest, 1953-68: A clinical and epidemiological study
Authors: R. S. Francis
Journal: Thorax (1971)

A study of acquired and primary drug resistance in pulmonary tuberculosis has been made in the London Borough of Waltham Forest over the 15-year period 1953-68. Aetiology, clinical and bacteriological features, treatment, and prognosis are examined and contrasted for both groups of patients. The incidence of both types of resistance is compared with the national incidence and is considered in relation to Commonwealth immigration into the borough. Reasons are suggested for the decline of the acquired and the rise in the primary type of resistance. National surveys of drug-resistant tuberculosis have served a valuable purpose in focussing epidemiological attention on the many problems raised by this potentially dangerous form of the disease.
Phase II Randomized Trial of Erlotinib or Vinorelbine in Chemonaive, Advanced, Non-small Cell Lung Cancer Patients Aged 70 Years or Older
Authors: Yuh-Min Chen, Chun-Ming Tsai, Wen-Chien Fan, Jen-Fu Shih, Shih-Hao Liu, Chieh-Hung Wu, Teh-Ying Chou, Yu-Chin Lee, Reury-Perng Perng, Jacqueline Whang-Peng
Journal: Journal of Thoracic Oncology (2011)
The Significance of Certain Dreams Reported by Psychosomatic Patients
Authors: Harold L. Levitan
Journal: Psychotherapy and Psychosomatics (1978)

Several types of dreams reported by psychosomatic patients with alexithymic characteristics are presented. Two special features of the dreams are noted: (1) the dreams contain events which are very traumatic and (2) the protagonists of the dreams failed to fully perceive their own feelings. It is postulated that the failure of the protagonists to fully perceive their own feelings played an important role in fostering the development of the traumatic events. Feelings such as anxiety and sadness are key signals which incite the ego of the dreamer to set protective operations into motion. The diminution of awareness of these feelings may, therefore, delay the implementation of protective operations to a point which allows the traumatic events to progress dangerously far. It is interesting to note that the few psychosomatic patients without alexithymic characteristics who were included in my series reported a type of dream which was identical to one of the types of dreams reported by patients with alexithymic characteristics. This concurrence suggests the possibility that the dreams form a link between the psychologies of these two sub-groups of psychosomatic patients.
Axillary lodine-131 Accumulation Due to Perspiration
Authors: ERNEST J. CAMPONOVO, PETER F. GOYER, EUGENE D. SILVERMAN, AARON M. KISTLER, WILLIAM M. YUDT
Journal: Clinical Nuclear Medicine (1989)

A case of spurious axillary uptake of I-131 proven to be caused by perspiration is presented. False-positive localizations of radioiodine, both pathologic and physiologic, are reviewed to avoid confusion of these entities with functioning thyroid carcinoma metastases.
Pentazocine reclassified in Illinois
Authors: May Annexton
Journal: JAMA (1978)

In the brief space of three months, a mild-to-potent analgesic has been made a schedule 2 (high potential for abuse) drug and given designated product status in the State of Illinois. Why the turnabout? Certainly the fault does not lie with Winthrop Laboratories, maker of pentazocine (Talwin) hydrochloride. Instead, the whole affair shows what can happen when a perfectly legitimate drug falls under the purview of clever "street" addicts. No one knows who thought of it first but, particularly in Chicago, crushed pentazocine tablets are being mixed with crushed tablets of tripelennamine (Pyribenzamine), an antihistamine. The mixture is dissolved in water and the solution injected intravenously. The combination, known on the street as "Ts and Blues," gives a cheap, heroin-like rush. It is so popular that, according to Peter Bensinger, administrator for the US Drug Enforcement Administration, US Department of Justice, 3 to 6 million doses of pentazocine have been
Placing Acupuncture in Perspective
Authors: Roy C. Ziegelstein
Journal: JAMA Internal Medicine (2013)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Internal Medicine HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Internal Medicine journal
Effectiveness of Distant Healing for Patients with Chronic Fatigue Syndrome: A Randomised Controlled Partially Blinded Trial (EUHEALS)
Authors: Harald Walach, Holger Bösch, George Lewith, Johannes Naumann, Barbara Schwarzer, Sonja Falk, Niko Kohls, Erlendur Haraldsson, Harald Wiesendanger, Alain Nordmann, Helgi Tomasson, Phil Prescott, Heiner C. Bucher
Journal: Psychotherapy and Psychosomatics (2008)

&lt;i&gt;Background:&lt;/i&gt; Distant healing, a form of spiritual healing, is widely used for many conditions but little is known about its effectiveness. &lt;i&gt;Methods:&lt;/i&gt; In order to evaluate distant healing in patients with a stable chronic condition, we randomised 409 patients with chronic fatigue syndrome (CFS) from 14 private practices for environmental medicine in Germany and Austria in a two by two factorial design to immediate versus deferred (waiting for 6 months) distant healing. Half the patients were blinded and half knew their treatment allocation. Patients were treated for 6 months and allocated to groups of 3 healers from a pool of 462 healers in 21 European countries with different healing traditions. Change in Mental Health Component Summary (MHCS) score (SF-36) was the primary outcome and Physical Health Component Summary score (PHCS) the secondary outcome. &lt;i&gt;Results:&lt;/i&gt; This trial population had very low quality of life and symptom scores at entry. There were no differences over 6 months in post-treatment MHCS scores between the treated and untreated groups. There was a non-significant outcome (p = 0.11) for healing with PHCS (1.11; 95% CI –0.255 to 2.473 at 6 months) and a significant effect (p = 0.027) for blinding; patients who were unblinded became worse during the trial (–1.544; 95% CI –2.913 to –0.176). We found no relevant interaction for blinding among treated patients in MHCS and PHCS. Expectation of treatment and duration of CFS added significantly to the model. &lt;i&gt;Conclusions:&lt;/i&gt; In patients with CFS, distant healing appears to have no statistically significant effect on mental and physical health but the expectation of improvement did improve outcome.
AMA develops measures of doctors' performance
Authors: Janice Tanne
Journal: BMJ (2006)

The American Medical Association (AMA) has agreed to government requests to develop evidence based measures of doctors' performance in collaboration with groups representing medical specialties and the federal Centers for Medicare and Medicaid Services.

The association has convened the Physician Consortium for Performance Improvement to develop by consensus 140 evidence based measures of doctors' performance in 34 clinical areas. The consortium includes representatives from more than 70 national medical specialty and state medical societies, the Agency for Healthcare Research and Quality and the Centers for Medicare and Medicaid Services, which administer the Medicare health insurance programme for elderly people and the Medicaid programme for children and people with low incomes.

Medicare payments to …
Point Mutation in the HCN4 Cardiac Ion Channel Pore Affecting Synthesis, Trafficking, and Functional Expression Is Associated With Familial Asymptomatic Sinus Bradycardia
Authors: Eyal Nof, David Luria, Dovrat Brass, Dina Marek, Hadas Lahat, Haya Reznik-Wolf, Elon Pras, Nathan Dascal, Michael Eldar, Michael Glikson
Journal: Circulation (2007)

The hyperpolarization-activated nucleotide-gated channel--HCN4 plays a major role in the diastolic depolarization of sinus atrial node cells. Mutant HCN4 channels have been found to be associated with inherited sinus bradycardia.Sixteen members of a family with sinus bradycardia were evaluated. Evaluation included a clinical questionnaire, 12-lead ECGs, Holter monitoring, echocardiography, and treadmill exercise testing. Eight family members (5 males) were classified as affected. All affected family members were asymptomatic with normal exercise capacity during long-term follow-up. Electrophysiological testing performed on 2 affected family members confirmed significant isolated sinus node dysfunction. Segregation analysis suggested autosomal-dominant inheritance. Direct sequencing of the exons encoding HCN4 revealed a missense mutation, G480R, in the ion channel pore domain in all affected family members. Function analysis, including expression of HCN4 wild-type and G480R in Xenopus oocytes and human embryonic kidney 293 cells, revealed that mutant channels were activated at more negative voltages compared with wild-type channels. Synthesis and expression of the wild-type and mutant HCN4 channel on the plasma membrane tested in human embryonic kidney 293 cells using biotinylation and Western blot analysis demonstrated a reduction in synthesis and a trafficking defect in mutant compared with wild-type channels.We describe an inherited, autosomal-dominant form of sinus node dysfunction caused by a missense mutation in the HCN4 ion channel pore. Despite its critical location, this mutation carries a favorable prognosis without the need for pacemaker implantation during long-term follow-up.
Sildenafil-induced cardioprotection in rabbits
Authors: R Kukreja
Journal: Cardiovascular Research (2003)

In the August issue of this journal, Reffelmann and Kloner [1] reported the effects of sildenafil (Viagra) on myocardial infarct size following ischemia–reperfusion (I–R). These authors showed that pretreatment with 0.7 or 1.45 mg/kg of sildenafil prior to ischemia resulted in no protection against myocardial infarction. These findings are in contrast with a previous study from our laboratory [2] that demonstrated a significant reduction of infarct size in the rabbits pretreated with 0.7 mg/kg sildenafil. The reason for this disagreement is not clear, as stated by Reffelmann and Kloner [1] that “…the contradictory results largely remain unexplained, but emphasize that additional factors, due to subtle differences in the experimental model, might be able to modify the cardiovascular response to sildenafil…”. We are certainly puzzled by these negative findings, since the sildenafil-induced cardioprotection has been observed independently by a number of …
True Knot of the Cord giving rise to Foetal Distress
Authors: J. Price
Journal: BMJ (1947)

Background/Aim: Most women are managed by a general gynaecologist rather than being centralized in an oncogynaecology unit, resulting in different clinical management. In 2006, a hub &amp; spoke model was introduced in the Provincial Healthcare System of Reggio Emilia, and shared guidelines were written. We aimed to verify the adherence to guidelines and the consequent improvements in quality care. Patients and Methods: All patients who underwent a hysterectomy for endometrial cancer in the Reggio Emilia Province hospitals from 2000 to 2016 were included in the study. Clinical and pathological data were carefully recorded for each patient included. Results: This study included 132 and 277 patients in the periods before and after the implementation of the guideline, respectively. In the post-guideline period, the use of hysteroscopy, magnetic resonance, laparoscopy and adjuvant treatment significantly increased. Conclusion: Common shared guidelines and a clinical audit can help in improving centralization, resulting in an increased quality of care.
Wound Healing
Authors: Leon C. Edwards, J. Englebert Dunphy
Journal: New England Journal of Medicine (1958)

INITIATED by Virchow's studies in cellular pathology, modern knowledge of the microscopical sequences of injury and healing was well established by the close of the last century. Increasing reliance for its understanding, however, is placed upon the biologic behavior of ions and molecules. Implemented by the technical advances of recent years, attacks on the problems of wound healing have multiplied, and their implications have broadened to include repair set in motion by injury of almost any kind and tissue loss at almost any site. The deep surface wound involves injury in several classes of tissue, and its reconstitution is characterized . . .
MININ'S ULTRA-VIOLET RAYS APPARATUS.
Authors: GUSTAVUS M. BLECH
Journal: JAMA (1902)

Since the discovery by Finsen that certain solar rays have decided therapeutic value in certain malignant affections (lupus, carcinoma) and a variety of inflammatory, benign affections, Minin of Russia has contributed a series of articles to contemporaneous literature pointing to the value of the ultra-violet rays in the above-named diseases. In fact the cures he reports in localized traumatic inflammations, in burns, inflammatory affections of the joints (arthritis, synovitis), lupus, contusions, superficial wounds, etc., are so astounding that the interest in phototherapy has received a new impetus. Minin maintains that the Finsen apparatus are very expensive and stationary and that treatment with them is frequently followed by a reaction necessitating a prolonged rest, thus making it obligatory for many patients to spend a good deal of time. Minin's apparatus consists of four ultra-violet electric lamps (one has a ground glass) with reflectors, stand, etc. It is very cheap and treatment
Clinical Guideline: Part II: Risk Stratification after Myocardial Infarction
Authors: Eric D. Peterson
Journal: Annals of Internal Medicine (1997)

Purpose: To review the literature on risk stratification after acute myocardial infarction in the reperfusion era and to propose an algorithm for early and continual risk assessment. Data Sources: A MEDLINE search of the English-language literature on humans was done using the terms myocardial infarction, prospective studies, and prognosis. This search was supplemented by narrowed searches for subheadings (such as cardiogenic shock, thrombolytic therapy, and stress testing) and surveys of references cited in review articles and book chapters. Study Selection: Literature on prognosis and myocardial infarction published from 1981 to 1996 was considered. From the literature on stress testing methods, studies that enrolled patients before 1980, enrolled patients for indications other than myocardial infarction, tested patients more than 6 weeks after infarction, were missing outcome data, or had inadequate follow-up were excluded. Data Extraction: Because too few randomized trials were available to allow the cross-comparison of risk-stratification methods, the available observational data were synthesized and supplemented with clinical judgments to produce recommendations. Data Synthesis: Risk stratification must begin when acute myocardial infarction is diagnosed. High-risk patients (such as those with cardiogenic shock) and candidates for reperfusion therapy must be identified quickly if ideal emergency care is to be given. At specific points during hospitalization, specialized tests may be useful if they add incremental information to the results of clinical evaluations. High-risk patients who have complications after infarction or significant left ventricular dysfunction probably benefit from early angiography; patients without these conditions are at low risk for recurrent events and should have noninvasive stress testing for further risk stratification. Conclusions: Physicians should continually reappraise risk throughout hospitalization to optimize both patient outcomes and cost containment.
Subphrenic abscess and recurring focal lesions due to tuberculosis in a patient with IgA deficiency
Authors: Amirreza Solhpour, Mahboubeh Hajiabdolbaghi, Sirous Jafari, Farzam Gorouhi, Shahriar Shahryaran, Zahra Abdi, Ali Solhpour, Alireza Yalda
Journal: Journal of Infection (2006)
CD169-Positive Macrophages Dominate Antitumor Immunity by Crosspresenting Dead Cell-Associated Antigens
Authors: Kenichi Asano, Ami Nabeyama, Yasunobu Miyake, Chun-Hong Qiu, Ai Kurita, Michio Tomura, Osami Kanagawa, Shin-ichiro Fujii, Masato Tanaka
Journal: Immunity (2010)