The Adverse Effect Dilemma: Quest for Accessible Information
Authors: Maura K. Roush, Robert A. McNutt, T. Flint Gray
Journal: Annals of Internal Medicine (1991)

Brief Reports15 February 1991The Adverse Effect Dilemma: Quest for Accessible InformationMaura K. Roush, PharmD, Robert A. McNutt, MD, T. Flint Gray, MDMaura K. Roush, PharmDSearch for more papers by this author, Robert A. McNutt, MDSearch for more papers by this author, T. Flint Gray, MDSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-114-4-298 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptWe report the case of a 23-year-old patient who developed pancreatitis while receiving enalapril for hypertension. Through an extensive literature review, a Freedom of Information search, and information from Merck Sharp and Dohme we confirmed our suspicion that the pancreatitis was caused by enalapril.Case ReportA 23-year-old woman developed hypertension 1 month after the delivery of her third child and was treated with metoprolol, 100 mg daily. A renal arteriogram was normal. Two months later, treatment with metoprolol was discontinued due to nightmares and nervousness,and treatment with enalapril, 5 mg daily, was initiated. One month later, while receiving only...References1. TilkemeierThompson PP. Acute pancreatitis possibly related to enalapril. N Engl J Med. 1988;318:1275-6. CrossrefMedlineGoogle Scholar2. ADRAC. Pancreatitis and ACE inhibitors. Australian Adverse Drug Reactions Bulletin. August 1989. Google Scholar3. Pedro-BotetMirallesCollRubies-Prat JRJJ. Captopril versus enalapril: cough versus pancreatitis. DICP Ann Pharmacother. 1990;24:438-9. MedlineGoogle Scholar4. Jones J. Adverse drug reactions in the community health setting: approaches to recognizing, counseling, and reporting. Fam Comm Health. 1982;5:58-67. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: From the University of North Carolina Hospitals, Chapel Hill, North Carolina. For current author addresses, see end of text. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byDrug-induced pancreatitis: focus on drugs used to treat cardiovascular diseaseCaptopril induced acute pancreatitis: a case reportDrug induced pancreatitis: A systematic review of case reports to determine potential drug associationsSome improvements are apparent in identifying adverse effects in systematic reviews from 1994 to 2011Sources of information on adverse effects: a systematic reviewDeveloping efficient search strategies to identify reports of adverse effects in medline and embaseAntihypertensive medication and the risk of acute pancreatitis: The European case-control study on drug-induced acute pancreatitis (EDIP)Fulminant Pancreatitis Associated with Ramipril TherapyAngioedema of the Small Bowel Due to an Angiotensin-converting Enzyme InhibitorDrug-Associated Acute Pancreatitis: Twenty-One Years of Spontaneous Reporting in The NetherlandsAcute pancreatitis following lisinopril rechallengePutative Roles of Bradykinin and the Kinin System in PancreatitisReview article: Drug-induced pancreatitisAngiotensin Converting Enzyme Inhibitor Therapy and Acute PancreatitisAcute Pancreatitis Associated with the Use of LisinoprilAntihypertensive drugsACE Inhibitors and PancreatitisSalim Dabaghi, MDAuthor's Reply 15 February 1991Volume 114, Issue 4Page: 298-299KeywordsClinical epidemiologyDrug informationHealth information technologyHospital medicineHypertensionPancreatitisPharmacology Issue Published: 15 February 1991 PDF downloadLoading ...