tbuckley/cabot-search huggingface dataset:
SYSTEMIC SPREAD OF A CYSTIC DUCT CARCINOMA: A CASE REPORT
Authors: A D REDMOND, J F MAJERANOWSKI
Journal: Annals of Internal Medicine (1954)

Case Reports1 March 1954SYSTEMIC SPREAD OF A CYSTIC DUCT CARCINOMA: A CASE REPORTARTHUR D. REDMOND, M.D., F.A.C.P., JOHN F. MAJERANOWSKI, M.B., Ch.B., M.D.ARTHUR D. REDMOND, M.D., F.A.C.P., JOHN F. MAJERANOWSKI, M.B., Ch.B., M.D.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-40-3-632 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptCarcinoma of the cystic duct is a comparatively rare condition. Kirshbaum and Kozoll3found seven cases in 13,330 autopsies. Ferrar2reviewed the literature on this subject and claimed that up to 1951 only 31 cases had been reported and, according to Stewart, Lieber and Morgan (quoted by Ferrar), not all of them are fully acceptable. None of the 15 tumors of extrahepatic bile ducts reported by Willis4could be labeled as pure cystic duct carcinomas. Eleven involved the common duct only, three arose in the hepatic duct, and one involved the common duct as well as the hepatic and cystic...Bibliography1. Ewing J: Neoplastic diseases, a treatise on tumors, 4th Ed., 1942, W. B. Saunders Company, Philadelphia, p. 156. Google Scholar2. Ferrar DA: Carcinoma of the cystic duct, Brit. J. Surg. 39: 183-185, 1951. CrossrefMedlineGoogle Scholar3. KirshbaumKozoll JDDD: Carcinoma of the gall bladder and extrahepatic bile ducts, Surg., Gynec. and Obst. 73: 740-754, 1941. Google Scholar4. Willis RA: Some aspects of the pathology of carcinomata of the biliary tracts, M. J. Australia 2: 340-344, 1942. CrossrefGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: ARTHUR D. REDMOND, M.D., F.A.C.P.; JOHN F. MAJERANOWSKI, M.B., Ch.B., M.D.Affiliations: Ogdensburg, N. Y.*Received for publication July 13, 1953.From the Division of Medicine and Department of Pathology, A. Barton Hepburn Hospital, Ogdensburg, N. Y.This paper was presented at the meeting of the Medical Society of the County of St. Lawrence, March 12, 1953. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byTumors and Tumor-Like Lesions of the Cystic DuctTumors and Tumor-like Lesions of the Cystic DuctCarcinoma of the cystic ductCarcinoma of the cystic duct: Case reportCarcinoma of the Cystic Duct with Gallbladder PerforationRICHARD H. PARKER, M.D.Neoplasms of the cystic and hepatic ducts 1 March 1954Volume 40, Issue 3Page: 632-640KeywordsAutopsyBile ductsHospital medicinePhotography ePublished: 1 December 2008 Issue Published: 1 March 1954 PDF downloadLoading ...
Vitiligo melanocytes in long-term culture show normal constitutive and cytokine-induced expression of intercellular adhesion molecule-1 and major histocompatibility complex class I and class II molecules
Authors: None Hedley, None Metcalfe, None Gawkrodger, None Weetman, None Mac Neil
Journal: British Journal of Dermatology (1998)

The aetiology of vitiligo remains unclear. An autoimmune involvement has been suggested and, in this study, we examine whether melanocytes cultured from unaffected regions of the skin of vitiligo patients are more susceptible to immune attack by investigating constitutive and cytokine‐stimulated expression of intercellular adhesion molecule‐1 (ICAM‐1) (under three media variants) and major histocompatibility complex (MHC) class I and class II (under one medium). Both normal and vitiligo melanocytes had similarly low constitutive expression of ICAM‐1 and MHC class II molecules, whereas > 95% of cells had high constitutive expression of MHC class I. Normal and vitiligo melanocytes showed similar and significant increases in the expression of all three immune‐related molecules in response to the cytokine, interferon‐gamma. The expression of ICAM‐1 was also similarly increased by the cytokine, tumour necrosis factor‐alpha in both cells. Additionally, it was noted that, once the melanocyte cultures were established under experimental conditions, the rate of proliferation of vitiligo melanocytes did not differ significantly from that of normal melanocytes. In conclusion, we suggest that vitiligo melanocytes, once in culture, do not have intrinsic differences from normal melanocytes with respect to the expression of immune‐related molecules.
Abstract P5-17-05: It's as simple as ABC: Can we improve the provision of coordinated medical and supportive care to patients with advanced breast cancer?
Authors: Sally Greenberg, Meron Pitcher, Bruce Mann, Kathleen Hendry, Kerry Shanahan, Melanie K Fisher, Jung H Foo
Journal: Cancer Research (2015)

Abstract Back ground: International and local guidelines regarding advanced breast cancer (ABC) management recommend coordinated care, discussion in multi-disciplinary meetings (MDM), breast care nurse (BCN) involvement and supportive care screening (SCS). There was concern among clinicians, at three University affiliated hospitals in Melbourne Australian, that these were not routinely performed for all patients at our hospitals. A WCMICS service improvement grant was used to design a Model of Care (MOC) aiming to address these deficiencies. Method: A 6 month retrospective audit of all new ABC patients was conducted at each institution. We reviewed timing and details of diagnosis, MDM discussions, BCN involvement, SCS and communication with primary care physicians (PCP). Surveys/ interviews of PCP, patients and oncology clinicians were conducted. A best practice MOC was developed, piloted for three months and evaluated. Results: The new MOC resulted in an increased proportion of patients discussed in MDM (from 33% to 88%), reviewed by a BCN (from 30% to 80%), and improved provision (from 61% to 90%) and timing (median 20 down to 16 days) of communication with PCP. 50% of patients interviewed in both the baseline and subsequent evaluation surveys did not feel their care was well coordinated between specialists and PCP. Conclusions: A best practice MOC for patients with newly diagnosed ABC is possible to implement across a number of institutions with improvements in the provision of coordinated medical and supportive care. Further improvements can be made in coordination of care between PCP and specialists. Citation Format: Sally Greenberg, Meron Pitcher, Bruce Mann, Kathleen Hendry, Kerry Shanahan, Melanie K Fisher, Jung H Foo. It's as simple as ABC: Can we improve the provision of coordinated medical and supportive care to patients with advanced breast cancer? [abstract]. In: Proceedings of the Thirty-Seventh Annual CTRC-AACR San Antonio Breast Cancer Symposium: 2014 Dec 9-13; San Antonio, TX. Philadelphia (PA): AACR; Cancer Res 2015;75(9 Suppl):Abstract nr P5-17-05.
Association between SNPs in NR3C1 and NR3C2 gene and asthma
Authors: Nienke Vink, Dirkje Postma, Judith Rosmalen, Marike Boezen
Journal: European Respiratory Journal (2011)

Background:  Stress is a risk factor for asthma. Single nucleotide polymorphisms (SNPs) in the glucocorticoid receptor ( NR3C1 ) and in the mineralocorticoid receptor ( NR3C2 ) have been associated with cortisol responses to stress. We hypothesized therefore that these SNPs are associated with individual susceptibility to asthma development.   Methods:  We studied the role of a history of asthma at age 16 years and SNPs in  NR3C1  (rs6196, rs10482642, rs4912903, rs6198, rs258813, rs33388, rs17100236, rs2963155, rs41423247, rs9324924, rs4244032, rs4607376) and  NR3C2  (rs5522, rs2070951) in the TRAILS study (n=2,230, 49% males). History of asthma at age 16 years was defined as doctor diagnosis asthma ever assessed at age 11 years and/or symptoms of asthma and/or using asthma treatment in the past 12 months assessed at age 11, 14 and 16 years. Logistic regression analyses were performed to study the association between SNPs and asthma using initially a general model (explored further in case of p   Results:  Ten percent (n=209) of all adolescents had a history of asthma at age 16. Individuals with homozygote variants for rs2070951 had a higher risk to develop asthma than individuals with heterozygote variants and wild types (GG vs CG/CC OR 1.58 (1.08-2.32), p=0.02). However, after correction for multiple testing this association was no longer significant. All other SNPs were not significantly associated with asthma.   Conclusion:  We showed no association between SNPs in  NR3C1  or  NR3C2  and asthma.
The Radiology of Skeletal Disorders. Exercises in Diagnosis.
Authors: Ronald O. Murray, Harold G. Jacobson, Dennis J. Stoker
Journal: Annals of Internal Medicine (1972)

8 Parts in 4 Volumes: PART I: FUNDAMENTALS of SKELETAL RADIOLOGY: Localised Congenital Disorders. Skeletal Trauma. Acute Injuries. Skeletal Trauma. Other Manifestations. Infections. Benign Neoplasms. Malignant Neoplasms. Metabolic and Endocrine Disorders. Haemopoietic Disorders. Arthritis. Miscellaneous Disorders. Hereditary Disorders. Osreochondrodysplasias. Congenital Shortness of Stature PART II: RADIOLOGICAL INVESTIGATIONS in ORTHOPAEDICS. PART III: SELF-ASSESSMENT in FUNDAMENTALS. PART IV: LESS COMMON DISORDERS. PART V: MISCELLANEOUS LESIONS in SPECIFIC ANATOMICAL AREAS. PART VI: MISCELLANEOUS LESIONS of the SKELETON with a DEFINITIVE RADIOLOGICAL DIAGNOSIS. PART VII: MISCELLANEOUS ABNORMALITIES of the SKELETON. MORE DIFFICULT DIAGNOSTIC PROBLEMS. PATY VIII: INVITED CONTRIBUTIONS: Radionuclide Scanning of Musculoskeletal Disorders. Computed Tomography. Applications to Musculoskeletal Disease. Magentic Resonance Imaging of the Musculoskeletal System. Ultrasonography of Musculoskeletal Disorders. Radiotherapy and Skeletal Disorders. Special Techniques in Orthopaedic Radiography. Detailed List of Contents. SUMMARIES of SALIENT FEATURES
Abstract 19015: Characteristics of Patients with Pulmonary Hypertension but without Cardiovascular Diseases: a Study with Echocardiography
Authors: Ayumi Nakaboh, Akiko Goda, Misato Otsuka, Mitsuru Masaki, Chikako Yoshida, Akiyo Eguchi, Shinichi Hirotani, Masaaki L Kawabata, Takeshi Tsujino, Tohru Masuyama
Journal: Circulation (2010)

Background: Pulmonary hypertension (PH) is frequently a manifestation of various systemic and cardiac diseases. While pulmonary artery pressure is now estimated in a routine part of an echo examination, such data have not been analyzed from the epidemiologic viewpoint, yet. Objective: The objective of this study is to clarify the underlying diseases in PH patients without cardiovascular diseases. Methods: PH was present in 2244 of 9491 subjects in whom echo study was done from January to December 2007, if PH was identified as the continuous wave Doppler-determined transtricuspid pressure gradient (TR-PG) of 25 mmHg or over. We retrospectively analyzed the prevalence of hypertension, atrial fibrillation, cancer, pulmonary disease, anemia, chronic kidney disease, collagen disease, and so on in the 2244 subjects. We measured mitral early diastolic flow velocity (E) and mitral anulus early diastolic velocity (E′) to estimate left atrial pressure (LAP) with the E/E′ ratio. Results: PH was present in 949 subjec...
Molecular, epidemiological and infectivity characterisation of a Mycobacterium tuberculosis strain prevalent in Madrid
Authors: A. Martín, F. Chaves, J. Iñigo, M. Alonso, C. Sola, N. Rastogi, M. J. Ruiz Serrano, E. Palenque, E. Bouza, D. García de Viedma
Journal: Clinical Microbiology and Infection (2007)
Interferon gamma release assays in screening for tuberculosis – Can we use them in patients with sarcoidosis?
Authors: Nils Milman, Claus B. Svendsen, Bolette Søborg, Aase B. Andersen
Journal: European Respiratory Journal (2011)

Treatment with tumour necrosis alpha (TNF-α) inhibitors has been introduced in recalcitrant sarcoidosis. These biologics may reactivate a latent tuberculosis infection (LTBI) and sarcoidosis patients are routinely LTBI tested before receiving TNF-α inhibitors. Until now, the tuberculin skin test (TST) has been used for LTBI screening among sarcoidosis patients in Denmark, even though the TST is unreliable with a low sensitivity in this specific group of patients. This study reports the results of an LTBI screening among recalcitrant sarcoidosis patients using the interferon gamma release assay (IGRA) QuantiFERON TB Gold (QFT). Secondly, the study assesses to which extent the QFT result is influenced by sarcoidosis disease activity. 44 sarcoidosis patients (22 men) with a median age of 38 years (range 25-59) were examined with QFT. Disease activity was assessed by biochemical blood markers, pulmonary function tests, chest X-ray and fluorine-18 fluorodeoxyglucose positron emission tomography (FDG-PET). 41/44 (93%) patients had a negative and 3/44 (7%) an indeterminate QFT test. 19/44 (43%) patients had activity in their sarcoidosis as judged by biochemical markers and 12/44 (27%) of these had a positive FDG-PET. None of the patients with a negative QFT had clinical, radiological or microbiological evidence of latent or latent tuberculosis infection. All patients were alive 5 years after the QFT test was performed. At the 5-year follow-up of in the National Danish Tuberculosis Registry, there was no registration of overt tuberculosis in any of the patients.
Reduction in Weight and Cardiovascular Disease Risk Factors in Individuals With Type 2 Diabetes
Authors: Xavier Pi-Sunyer, George Blackburn, Frederick L Brancati, George A Bray, Renee Bright, Jeanne M Clark, Jeffrey M Curtis, Mark A Espeland, John P Foreyt, Kathryn Graves, Steven M Haffner, Barbara Harrison, James O Hill, Edward S Horton, John Jakicic, Robert W Jeffery, Karen C Johnson, Steven Kahn, David E Kelley, Abbas E Kitabchi, William C Knowler, Cora E Lewis, Barbara J Maschak-Carey, Brenda Montgomery, David M Nathan, Jennifer Patricio, Anne Peters, J Bruce Redmon, Rebecca S Reeves, Donna H Ryan, Monika Safford, Brent Van Dorsten, Thomas A Wadden, Lynne Wagenknecht, Jacqueline Wesche-Thobaben, Rena R Wing, Susan Z Yanovski
Journal: Diabetes Care (2007)

OBJECTIVE—The effectiveness of intentional weight loss in reducing cardiovascular disease (CVD) events in type 2 diabetes is unknown. This report describes 1-year changes in CVD risk factors in a trial designed to examine the long-term effects of an intensive lifestyle intervention on the incidence of major CVD events. RESEARCH DESIGN AND METHODS—This study consisted of a multicentered, randomized, controlled trial of 5,145 individuals with type 2 diabetes, aged 45–74 years, with BMI &amp;gt;25 kg/m2 (&amp;gt;27 kg/m2 if taking insulin). An intensive lifestyle intervention (ILI) involving group and individual meetings to achieve and maintain weight loss through decreased caloric intake and increased physical activity was compared with a diabetes support and education (DSE) condition. RESULTS—Participants assigned to ILI lost an average 8.6% of their initial weight vs. 0.7% in DSE group (P &amp;lt; 0.001). Mean fitness increased in ILI by 20.9 vs. 5.8% in DSE (P &amp;lt; 0.001). A greater proportion of ILI participants had reductions in diabetes, hypertension, and lipid-lowering medicines. Mean A1C dropped from 7.3 to 6.6% in ILI (P &amp;lt; 0.001) vs. from 7.3 to 7.2% in DSE. Systolic and diastolic pressure, triglycerides, HDL cholesterol, and urine albumin-to-creatinine ratio improved significantly more in ILI than DSE participants (all P &amp;lt; 0.01). CONCLUSIONS—At 1 year, ILI resulted in clinically significant weight loss in people with type 2 diabetes. This was associated with improved diabetes control and CVD risk factors and reduced medicine use in ILI versus DSE. Continued intervention and follow-up will determine whether these changes are maintained and will reduce CVD risk.
Defining Amyloid Pathology in Persons With and Without Dementia Syndromes
Authors: Roger N. Rosenberg
Journal: JAMA (2015)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
687. Parainfluenza Virus-Mediated Delivery of CFTR to Ciliated Cells Corrects the CF Bioelectrical Chloride Secretory Defect and Restores the Regulation of Airway Surface Liquid Depth and Mucus Transport to Cystic Fibrosis Airway Epithelium
Authors: L. Zhang, B. Button, M. H. Skiadopoulos, Y. Dang, A. Bukreyev, S. E. Gabriel, P. L. Collins, R. J. Pickles
Journal: Molecular Therapy (2004)
Let There Be Light-the Laser in Dentistry
Authors: Christopher Mercer
Journal: Journal of the Royal Society of Medicine (1992)

A damp and dull London day in March somewhat contradicted the title of the meeting of the Odontology Section of the RSM, Let there be light--the laser in dentistry, but there was no doubt, once inside, that the organisers had, with perfect timing, caught the interest of the profession as a Barnes Room packed to capacity was greeted by the president of the section, Margaret Seward. Rather apologetically, she confessed that the film Goldfinger was unavailable, but promised us equal fascination with a galaxy of international experts to guide us through a maze of new developments in laser dentistry.
Abstract 12589: Quantitative Assessment of Mid-Systolic Deceleration and Notching in the Right Ventricular Ejection Doppler Envelope is Useful in Predicting Hemodynamics and Patient Outcomes in Pulmonary Arterial Hypertension
Authors: Hiroko Takahama, Garvan C Kane
Journal: Circulation (2014)

Background: Increased reflective wave from pulmonary artery (PA) causes mid-systolic deceleration (MSD) and notching in Doppler flow velocity envelope of RV ejection flow. Our aim is to test whether profile of MSD and notching provides insight into hemodynamics and patient outcomes in pulmonary artery hypertension (PAH), using quantitative measurements. We hypothesized that the deceleration time of the MSD slope (DTMSD), meaning the steepness of the slope, reflects interaction between RV ejection and reflective wave, and that peak velocity of post-notching flow (Vpost) reflects RV function. Methods: We reviewed RV ejection flow envelope recordings by pulsed wave Doppler for 157 consecutive patients with PAH between 1/2008 and 3/2013 (age 57 ± 14) with an estimated RV systolic pressure of 79 ± 23 mmHg. DTMSD was measured as the time between the first peak acceleration wave and MSD slope extrapolated to zero line. We also reviewed right heart catheterization performed within one month from echocardiography in 78 of the 157 patients. Results: We identified MSD and notching in 148 patients. On multivariate regression analyses, PA capacitance was the key determinant of DTMSD (beta = -0.49, p &lt;0.0001). Vpost was determined by cardiac index (beta = -0.36, p = 0.0014). During a median follow-up period of 30 months, there were 47 deaths from all causes and 7 lung transplantations. On Cox hazard analyses, shorter DTMSD and smaller Vpost are significant predictors of higher mortality independently of each other (HR 0.92 / 10ms, p = 0.045 and HR 0.97, p = 0.028, respectively). Conclusion: Mid-systolic deceleration of RV ejection flow became steeper in the setting of lower PA compliance causing a greater reflectance wave. Reduced peak velocity of post-notching flow reflected impaired RV with reduced cardiac output. Quantitative assessment of profile of mid-systolic deceleration and notching in RV ejection flow envelope is useful in predicting hemodynamics and patient outcomes in PAH.
In Vitro Study Of The Mechanisms Involved In The Bone Marrow Mesenchymal Stromal Cell Modulatory Effect On B Cell Function
Authors: Eliana Amati, Giulio Bassi, Mariano Di Trapani, Francesco Liotta, Francesco Annunziato, Omar Perbellini, Mario Ricciardi, Giovanni Pizzolo, Maria Teresa Scupoli, Mauro Krampera
Journal: Blood (2013)
PHS Provides Immunoglobulin
Authors: Brian Vastag
Journal: JAMA (2002)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal