tbuckley/cabot-search huggingface dataset:
A controlled trial of desipramine in 18 men with posttraumatic stress disorder
Authors: C Reist, C D Kauffmann, R J Haier, C Sangdahl, E M DeMet, A Chicz-DeMet, J N Nelson
Journal: American Journal of Psychiatry (1989)

Eighteen male U.S. veterans meeting DSM-III criteria for posttraumatic stress disorder (PTSD) completed a 4-week double-blind, crossover study comparing administration of 200 mg/day of desipramine with placebo. Response was measured by using the Beck Depression Inventory, the Hamilton Rating Scale for Depression, the Hamilton Rating Scale for Anxiety, and the Impact of Event Scale. Overall, the only apparent response to desipramine was in some symptoms of depression; there were no changes in anxiety and other PTSD symptoms.
PSYCHIATRIC INVESTIGATION IN INTERNAL MEDICINE
Authors: Marie L. Carns, Annette C. Washburne
Journal: Annals of Internal Medicine (1933)

Article1 November 1933PSYCHIATRIC INVESTIGATION IN INTERNAL MEDICINEMARIE L. CARNS, M.D., ANNETTE C. WASHBURNE, M.D.MARIE L. CARNS, M.D.Search for more papers by this author, ANNETTE C. WASHBURNE, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-7-5-664 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThere is nothing novel in the idea that adequate medical care cannot be given to a patient unless his mental and emotional difficulties are understood. However, it seems to us that at present little of a concrete nature is being done in many medical departments in this country to apply this idea. The usual routine consists of a thorough study of the patient for the purpose of ruling out any organic pathology, and this being satisfactorily accomplished, he is discharged with only some such diagnosis as neurasthenia, and possibly a prescription for a sedative. Medical responsibility has seemed too often...References1. BLECKWENN WJ: Production of sleep and rest in psychotic cases, Arch. Neurol. and Psychiat., 1930, xxiv, 365-372.—Narcosis as therapy in neuropsychiatric conditions, Jr. Am. Med. Assoc., 1930, xcv, 1168-1171.—Sodium amytal in certain nervous and mental conditions, Wisconsin Med. Jr., 1930, xxix, 693-696. CrossrefGoogle Scholar2. LORENZ WF: Criminal confessions under narcosis, Wisconsin Med. Jr., 1932, xxxi, 245-250. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Madison, Wisconsin*Received for publication April 18, 1933.From the Departments of Medicine and Neuro-Psychiatry, Wisconsin General Hospital, Madison, Wisconsin. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 November 1933Volume 7, Issue 5Page: 664-668KeywordsEmotionsHospital medicineSedatives ePublished: 1 December 2008 Issue Published: 1 November 1933 PDF downloadLoading ...
Human immunodeficiency virus and liver transplantation: Hepatitis C is the last hurdle
Authors: Peter G. Stock, Norah A. Terrault
Journal: Hepatology (2014)

1Departments of Surgery and MedicineUniversity of California San FranciscoSan FranciscoCA *Address reprint requests to: Norah Terrault, M.D., Departments of Surgery and Medicine, University of California San Francisco, S357, 513 Parnassus Avenue, San Francisco, CA 94143. E‐mail: [email protected]; fax: +1‐415‐476‐0659.
PROTEINURIA FOLLOWING NEPHRECTOMY AND INTRAVENOUS INJECTION OF LARGE AMOUNTS OF HUMAN PROTEIN
Authors: S TRUBOWITZ
Journal: Annals of Internal Medicine (1952)

Case Reports1 March 1952PROTEINURIA FOLLOWING NEPHRECTOMY AND INTRAVENOUS INJECTION OF LARGE AMOUNTS OF HUMAN PROTEINSIDNEY TRUBOWITZ, M.D., F.A.C.P.SIDNEY TRUBOWITZ, M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-36-3-873 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptProteinuria can be produced with statistically significant regularity in rats by the reduction of renal tissue to the minimum compatible with life.4There is no reason to believe that the human kidney behaves differently from that of the rat, but direct evidence is not at hand, for the experimental methods used in the physiology laboratory on the rat are obviously not applicable to the study of human renal function. The purpose of this paper is to present the findings in a patient from whom, for therapeutic reasons, one kidney was removed, and who immediately thereafter received a large amount of...Bibliography1. Addis T: Glomerulonephritis, 1948, The Macmillan Company, New York, p. 57. Google Scholar2. AddisBarretLewPooYuen TEWLJDW: Danger of intravenous injections of protein solutions after sudden loss of renal tissue, Arch. Int. Med. 77: 255 (March) 1946. CrossrefGoogle Scholar3. BradleyBradley SEGP: The effect of increased intra-abdominal pressure on renal function, J. Clin. Investigation 26: 1010 (Sept.) 1947. CrossrefMedlineGoogle Scholar4. ChanutinFerris AEB: Experimental renal insufficiency produced by partial nephrectomy, Arch. Int. Med. 49: 76 (May) 1932. CrossrefGoogle Scholar5. DerowSchlesingerSavits HAMJHA: Chronic progressive occlusion of the inferior vena cava and the renal and portal veins, Arch. Int. Med. 63: 626 (April) 1939. CrossrefGoogle Scholar6. Wald H: The weight of normal adult human kidneys and its variability, Arch. Path. 23: 493 (April) 1937. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Staten Island, N. Y.*Received for publication December 21, 1949.From the Medical Service, Halloran V. A. Hospital, Staten Island, New York.Sponsored by Veterans Administration and published with approval of Chief Medical Director. The statements and conclusions published by the author are a result of his own study and do not necessarily reflect opinion or policy of Veterans Administration. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byDie Grundstoffe der Nahrung 1 March 1952Volume 36, Issue 3Page: 873-880KeywordsIntravenous injectionsKidneysMedical servicesNephrectomyProteinsProteinuriaRenal physiologyResearch laboratories ePublished: 1 December 2008 Issue Published: 1 March 1952 PDF downloadLoading ...
Abstract 12117: The Cardioprotection of Trimetazidine Against Ischemic Injury is Mediated by AMPK and ERK Signaling Pathway
Authors: Zhenling Liu, Yina Ma, Michelle Kuznicki, Xingchi Chen, Wanqing Sun, Ping Zhu, Ji Li
Journal: Circulation (2014)

Introduction: Trimetazidine (TMZ) is an anti-anginal drug that has been widely used in Europe and Asia. The TMZ can optimize energy metabolism via inhibition of long-chain 3-ketoacyl CoA thiolase (3-KAT) in the heart, with subsequent decrease in fatty acid oxidation and stimulation of glucose oxidation. However, the mechanism by which TMZ aids in cardioprotection against ischemic injury has not been characterized. Hypothesis: AMP-activated protein kinase (AMPK) is an energy sensor that control ATP supply from substrate metabolism and protect heart from energy stress. TMZ changes the cardiac AMP/ATP ratio via modulating fatty acid oxidation, thereby it may trigger AMPK signaling cascade that contribute to protection heart from ischemia/reperfusion (I/R) injury. Methods: The mouse in vivo regional ischemia and reperfusion by the ligation of the left anterior descending coronary artery (LAD) were used for determination of myocardial infarction. The infarct size was compared between C57BL/6J WT mice and AMPK kinase dead (KD) transgenic mice with or without TMZ treatment. The ex vivo working heart perfusion system was used to monitor the effect of TMZ on glucose oxidation and fatty acid oxidation in the heart. Results: TMZ treatment significantly stimulates cardiac AMPK and extracellular signal-regulated kinase (ERK) signaling pathways (p&lt;0.05 vs. vehicle group). The administration of TMZ reduces myocardial infarction size in WT C57BL/6J hearts, the reduction of myocardial infarction size by TMZ in AMPK KD hearts was significantly impaired versus WT hearts (p&lt;0.05). Intriguingly, the administration of ERK inhibitor, PD 98059, to AMPK KD mice abolished the cardioprotection of TMZ against I/R injury. The ex vivo working heart perfusion data demonstrated that TMZ treatment significantly activates AMPK signaling and modulating the substrate metabolism by shifting fatty acid oxidation to glucose oxidation during reperfusion, leading to reduction of oxidative stress in the I/R hearts. Conclusions: Both AMPK and ERK signaling pathways mediate the cardioprotection of TMZ against ischemic injury. The metabolic benefits of TMZ for angina patients could be due to the activation of energy sensor AMPK in the heart by TMZ administration.
抗生素耐药性是否日趋严重?该问题由来已久,但我们仍可有所作为
Authors: Hart, 王爱霞
Journal: BMJ (1998)

虽然抗生素时代始于1928年,当时弗莱明发现了真菌中点青霉的作用,但是,直至1940年才研制出相当纯的、可以用于治疗人类疾病的青霉素。不幸的是,在前些年已有关于一种β内酰胺酶(青霉素酶)可以使青霉素失活的报道。在其后的几十年
T-cell progenitor function during progressive human immunodeficiency virus-1 infection and after antiretroviral therapy
Authors: Dawn R. Clark, Sjoerd Repping, Nadine G. Pakker, Jan M. Prins, Daan W. Notermans, Ferdinand W. N. M. Wit, Peter Reiss, Sven A. Danner, Roel A. Coutinho, Joep M. A. Lange, Frank Miedema
Journal: Blood (2000)
CONTACT DEKMATITIS XIV.
Authors: Gun Agrup
Journal: British Journal of Dermatology (1971)

Journal Article CONTACT DEKMATITIS XIV: On Terminology of Contact Dermatitis Get access Gun Agrup Gun Agrup Department of Dermatology Lund Sweden Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 84, Issue 4, 1 April 1971, Pages 389–391, https://doi.org/10.1111/j.1365-2133.1971.tb14240.x Published: 01 April 1971
POLIOMYELITIS: EARLY DIAGNOSIS AND EARLY MANAGEMENT OF ACUTE CASES
Authors: JOHN R. PAUL, M.D., F.A.C.P.
Journal: Annals of Internal Medicine (1949)

ExcerptThe title of this paper indicates that it will be concerned with early aspects of diagnosis and therapy. But the adjectiveearlyshould be especially stressed, for, from the standpoint of the acute infection, the early and critical stage of poliomyelitis has heretofore been regarded clinically as the prodromal stage. By the time patients begin to show evidence of paralysis, and often by the time they reach the hospital, it may be late in the disease and the critical period is already passed. Thus according to Russell1: "the battle to decide the fate of the spinal-cord cells is probably over...
658. Different Regulation of Atrial and Ventricular HSP70 mRNA Expression during Warm Blood Cardioplegic Arrest in Rats
Authors: Ernö Remsey-Semmelweis, John G. Kral, Richard B. Wait, M. A. Q. Siddiqui
Journal: Molecular Therapy (2004)

Objectives: Normothermic blood cardioplegia (CWBCP) is considered as non-ischemic cardioprotection. Heat shock protein (HSP70) and creatine kinase (MCK) are markers of myocardial integrity and ischemia. We hypothesized that changes occur in atrial(A) and in ventricular(V) mRNA expression during CWBCP arrest and that A and V respond differently.
Abstract 13877: Has Late Rejection Decreased in Pediatric Heart Transplantation in the Current Era? A Multi-institutional Study.
Authors: Rebecca Ameduri, Jie Zheng, Kenneth Schechtman, Timothy Hoffman, Robert J Gajarski, Richard E Chinnock, David C Naftel, James K Kirklin, Anne I Dipchand, Charles E Canter
Journal: Circulation (2010)

Background: Late (occurring > 1yr) rejection (LR) has been shown to increase mortality and morbidity after pediatric heart transplantation (HTx) with an increased risk in older and non-white recipi...
Hybrid SPECT/CT Evaluation of Dual Ectopia of Thyroid in the Absence of Orthotopic Thyroid Gland
Authors: Chidambaram Natrajan Balasubramanian Harisankar, Govindababu Rajalakshmi Preethi, Mv George
Journal: Clinical Nuclear Medicine (2012)

Ectopic thyroid tissue (ETT) refers to all cases in which the thyroid gland is present at a location other than its usual site. The prevalence of ETT is approximately 1 per 100,000 to 300,000 persons and is reported to occur in 1 of 4000 to 8000 patients with thyroid disease. Multiple ectopia of the thyroid is extremely rare, with fewer than 35 cases published in literature to date. We report a 4-year-old girl with euthyroid and dual ectopia of thyroid without orthotopic thyroid gland. The role of hybrid SPECT/CT in the localization of the sites of ETT is also highlighted.
Abstract 2013: NEDD9 depletion leads to MMP14 inactivation by TIMP2 and prevents invasion and metastasis
Authors: Elena N. Pugacheva, Sarah McLaughlin, Ryan Ice, Anuradha Rajulapati, Polina Kozyulina, Ryan Livengood, Varvara Kozyreva, Yuriy Loskutov, Alexey Ivanov, Scott Weed
Journal: Cancer Research (2014)

Abstract The scaffolding protein NEDD9 is an established pro-metastatic marker in several cancers. Nevertheless, the molecular mechanisms of NEDD9 driven metastasis in cancers remain ill defined. Here, using a comprehensive breast cancer (BCa) tissue microarray, we show that increased levels of NEDD9 protein significantly correlated with the transition from carcinoma in situ to invasive carcinoma. NEDD9 expression is crucial for the mesenchymal invasion of cancer cells at the primary site but not at the metastatic site. Depletion of NEDD9 is sufficient to suppress invasion, leading to decrease in circulating tumor cells (CTCs) and lung metastases in xenograft models. Mechanistically, NEDD9 localizes to invasive pseudopods and is required for local matrix degradation via regulation of MMP14 trafficking. Depletion of NEDD9 impaired invasion of cancer cells through inactivation of MMP14 by excess TIMP2 on the cell surface. Re-expression of NEDD9 is sufficient to restore the activity of MMP14 and the invasive properties of BCa cells. Collectively, these findings uncover critical steps in invasion of BCa cells with potential strategy to target metastasis through manipulation of NEDD9. Citation Format: Elena N. Pugacheva, Sarah McLaughlin, Ryan Ice, Anuradha Rajulapati, Polina Kozyulina, Ryan Livengood, Varvara Kozyreva, Yuriy Loskutov, Alexey Ivanov, Scott Weed. NEDD9 depletion leads to MMP14 inactivation by TIMP2 and prevents invasion and metastasis. [abstract]. In: Proceedings of the 105th Annual Meeting of the American Association for Cancer Research; 2014 Apr 5-9; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2014;74(19 Suppl):Abstract nr 2013. doi:10.1158/1538-7445.AM2014-2013
Dual role of B7 costimulation in obesity-related nonalcoholic steatohepatitis and metabolic dysregulation
Authors: Antonios Chatzigeorgiou, Kyoung-Jin Chung, Ruben Garcia-Martin, Vasileia-Ismini Alexaki, Anne Klotzsche-von Ameln, Julia Phieler, David Sprott, Waldemar Kanczkowski, Theodora Tzanavari, Mohktar Bdeir, Sibylle Bergmann, Marc Cartellieri, Michael Bachmann, Polyxeni Nikolakopoulou, Andreas Androutsellis-Theotokis, Gabriele Siegert, Stefan R. Bornstein, Michael H. Muders, Louis Boon, Katia P. Karalis, Esther Lutgens, Triantafyllos Chavakis
Journal: Hepatology (2014)

The low-grade inflammatory state present in obesity contributes to obesity-related metabolic dysregulation, including nonalcoholic steatohepatitis (NASH) and insulin resistance. Intercellular interactions between immune cells or between immune cells and hepatic parenchymal cells contribute to the exacerbation of liver inflammation and steatosis in obesity. The costimulatory molecules, B7.1 and B7.2, are important regulators of cell-cell interactions in several immune processes; however, the role of B7 costimulation in obesity-related liver inflammation is unknown. Here, diet-induced obesity (DIO) studies in mice with genetic inactivation of both B7.1 and B7.2 (double knockout; DKO) revealed aggravated obesity-related metabolic dysregulation, reduced insulin signalling in the liver and adipose tissue (AT), glucose intolerance, and enhanced progression to steatohepatitis resulting from B7.1/B7.2 double deficiency. The metabolic phenotype of B7.1/B7.2 double deficiency upon DIO was accompanied by increased hepatic and AT inflammation, associated with largely reduced numbers of regulatory T cells (Tregs) in these organs. In order to assess the role of B7 costimulation in DIO in a non-Treg-lacking environment, we performed antibody (Ab)-mediated inhibition of B7 molecules in wild-type mice in DIO. Antibody-blockade of both B7.1 and B7.2 improved the metabolic phenotype of DIO mice, which was linked to amelioration of hepatic steatosis and reduced inflammation in liver and AT. Conclusion : Our study demonstrates a dual role of B7 costimulation in the course of obesity-related sequelae, particularly NASH. The genetic inactivation of B7.1/B7.2 deteriorates obesity-related liver steatosis and metabolic dysregulation, likely a result of the intrinsic absence of Tregs in these mice, rendering DKO mice a novel murine model of NASH. In contrast, inhibition of B7 costimulation under conditions where Tregs are present may provide a novel therapeutic approach for obesity-related metabolic dysregulation and, especially, NASH. (Hepatology 2014;60:1196–1210)
Abstract 9610: Aortic Stiffness and Increased Left Ventricular Mass Predict Progress From Prehypertension to Hypertension
Authors: Yong H Kim, Seong-Hwan Kim, Jin-Seok Kim, Chol Shin, Seung-Ku Lee
Journal: Circulation (2014)

Introduction: Whether aortic stiffness and increased left ventricular (LV) mass can predict progress from prehypertension to hypertension is not well investigated. Hypothesis: The aim of this study was to find predictors of hypertension and evaluate the clinical implications of aortic stiffness and increased LV mass in disease-free prehypertensive population. Methods: 510 prehypertensive subjects in the Korean Genome Epidemiology Study (KoGES) were observed for four years. In addition to clinical information, left ventricular mass index (LVMI), left atrial volume index (LAVI), aortic pulse wave velocity (PWV), carotid intima-media thickness (cIMT) and other cardiovascular characteristics were obtained at baseline. Baseline clinical and cardiovascular characteristics were compared between subjects that developed hypertension and did not, and independent predictors of hypertension were determined. Results: Out of 510 participants, 237 subjects developed hypertension during four years (46%). After multivariate adjustment, high range prehypertension (OR=4.27 [2.63-9.63], p=0.000), 5th quintile of LAVI (OR=3.38 [1.63-7.04], p=0.001), 5th quintile of LVMI (OR=2.982 [1.399-6.359], p=0.005), 4th (OR=2.881 [1.372-6.049], p=0.005) and 5th quintiles of PWV (OR=2.283 [1.067-4.885], p=0.033) predicted development of hypertension. Subjects in low range prehypertension at baseline and hypertension at the final visit (“fast increase in blood pressure (BP)”) had the highest baseline LVMI, while those with high range prehypertension at baseline and not-hypertension at the final visit ("slow increase in BP") had the lowest baseline LVMI (p=0.005 for fast BP increase vs. slow BP increase). Conclusions: In prehypertensive population, presence of aortic stiffness and increased LV mass independently predicted development of hypertension. Further, increased LVMI at baseline was correlated with fast increase in BP in the future. PWV and echocardiography should be performed to recognize subjects at high risk of hypertension, because they possibly benefit from pre-emptive medical treatment.
Dermoid cyst with magnetic resonance image of sack-of-marbles
Authors: N. Fujimoto, N. Fujii, Y. Nagata, T. Uenishi, T. Tanaka
Journal: British Journal of Dermatology (2007)

Journal Article Dermoid cyst with magnetic resonance image of sack‐of‐marbles Get access N. Fujimoto, N. Fujimoto Department of Dermatology, Shiga University of Medical Science, Setatsukinowa, Otsu, Shiga 520‐2192, Japan E‐mail: noriki@belle.shiga‐med.ac.jp Search for other works by this author on: Oxford Academic Google Scholar N. Fujii, N. Fujii Department of Dermatology, Shiga University of Medical Science, Setatsukinowa, Otsu, Shiga 520‐2192, Japan E‐mail: noriki@belle.shiga‐med.ac.jp Search for other works by this author on: Oxford Academic Google Scholar Y. Nagata, Y. Nagata Department of Dermatology, Shiga University of Medical Science, Setatsukinowa, Otsu, Shiga 520‐2192, Japan E‐mail: noriki@belle.shiga‐med.ac.jp Search for other works by this author on: Oxford Academic Google Scholar T. Uenishi, T. Uenishi Department of Dermatology, Shiga University of Medical Science, Setatsukinowa, Otsu, Shiga 520‐2192, Japan E‐mail: noriki@belle.shiga‐med.ac.jp Search for other works by this author on: Oxford Academic Google Scholar T. Tanaka T. Tanaka Department of Dermatology, Shiga University of Medical Science, Setatsukinowa, Otsu, Shiga 520‐2192, Japan E‐mail: noriki@belle.shiga‐med.ac.jp Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 158, Issue 2, 1 February 2008, Pages 415–417, https://doi.org/10.1111/j.1365-2133.2007.08321.x Published: 01 February 2008
Experimenting with Humans and Animals: From Galen to Animal Rights
Authors: J. P. Gluck
Journal: JAMA (2004)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Tissue resident regulatory T cells: novel therapeutic targets for human disease
Authors: Xiaohui Zhou, Jiayou Tang, Hao Cao, Huimin Fan, Bin Li
Journal: Cellular and Molecular Immunology (2015)

Over the past decade, the ability of regulatory T cells (Tregs) to suppress multiple types of immune cells has received tremendous attention. Mounting evidence has revealed that tissue resident Tregs control non-immunological processes of their target tissues and contribute to a plethora of human diseases. The identification of novel tissue-specific Tregs has highlighted their heterogeneity and complexity. This review summarizes the recent findings for visceral adipose tissue CD4+Foxp3+ regulatory T cells (VAT Tregs), muscle Tregs, bone Tregs and skin memory Tregs, with a focus on their unique functions in local tissues. This interpretation of the roles of tissue-specific Tregs and of their involvement in disease progression provides new insight into the discovery of potential therapeutic targets of human diseases.
Electrocardiography in Clinical Practice.
Authors: Te-Chuan Chou
Journal: Annals of Internal Medicine (1980)

Dicusses ECG findings, cardiac arrhythmias, drug effects, electrolyte imbalance, trauma, cardiac transplantation, pacemakers and ambulatory electrocardiogram. Detailed information emphasizing the value and limitations of the electrocardiogram, the differential diagnosis of the electrocardiographic findings and their correlation with clinical and anatomical data.