tbuckley/cabot-search huggingface dataset:
Increased circulating levels of neurotrophins and elevated expression of their high-affinity receptors on skin and gut mast cells in mastocytosis
Authors: Wen-Ming Peng, Laura Maintz, Jean-Pierre Allam, Ulrike Raap, Ines Gütgemann, Jutta Kirfel, Eva Wardelmann, Sven Perner, Wei Zhao, Rolf Fimmers, Klaus Walgenbach, Johannes Oldenburg, Lawrence B. Schwartz, Natalija Novak
Journal: Blood (2013)
CARDIAC INJURY BY RADIOFREQUENCY ENERGY DURING CATHETER ABLATION PREDICTS PROGNOSIS IN ATRIAL FIBRILLATION
Authors: Sanghamitra Mohanty, Prasant Mohanty, Luigi Di Biase, Chintan Trivedi, Rong Bai, Pasquale Santangeli, John Burkhardt, Rodney Horton, Joe Gallinghouse, Javier Sanchez, Jason Zagrodzky, Shane Bailey, Patrick Hranitzky, Amin Al Ahmad, Andrea Natale
Journal: Journal of the American College of Cardiology (2014)
Scleromyxoedema: treatment of cutaneous and systemic manifestations with high-dose intravenous immunoglobulin
Authors: A. Kulczycki, M. Nelson, A. Eisen, M. Heffernan
Journal: British Journal of Dermatology (2003)

Scleromyxoedema is a rare disease characterized by cutaneous sclerosis, mucin deposition and paraproteinaemia. Internal disease is common, particularly musculoskeletal, gastrointestinal and central nervous system involvement. We report a series of three consecutive patients with scleromyxoedema treated with high‐dose intravenous immunoglobulin (hdIVIg). Each of the three patients had relatively low levels of a highly basic IgG‐λ paraprotein, and each has demonstrated a sustained response of both their cutaneous and extracutaneous disease to hdIVIg. As all patients had perioral skin involvement and microstomia, one measure of cutaneous improvement was the increase in intraincisor distance. Extracutaneous manifestations of scleromyxoedema that improved included ureteral stricture, vocal strength and dysphagia.
Comparison of 11C-L-methionine uptake by the parotid gland and pancreas in chronic pancreatitis studied by positron emission tomography.
Authors: A Syrota, P Collard, A Paraf
Journal: Gut (1983)

L-methionine uptake by the parotid gland and pancreas has been compared in 27 patients using a non-invasive methodology. L-methionine was labelled with 11C, a positron emitter with a short half life produced in a cyclotron. 11C-L-methionine concentration was measured in the parotid glands and in the pancreas by external detection using a positron emission tomographic system. 11C-L-methionine uptake by the parotid glands was 4.3 X 10(-3) +/- 1.9 X 10(-3)% of the injected dose per millilitre of tissue (mean +/- SD) in a group of 11 normal non-alcoholic subjects. The uptake was 3.6 +/- 1.3 (X10(-3) in a group of nine alcoholic subjects without pancreatic disorder and it was 4.9 +/- 1.5 (X10(-3) in a third group of seven patients with chronic pancreatitis. These values did not significantly differ. In contrast median pancreatic uptake of 11C-L-methionine was nil in chronic pancreatitis and was lower than that seen in normal subjects (15.3 X 10(-3)% ml, p less than 0.001) and in alcoholic subjects (11.5 X 10(-3)% ml, p less than 0.002). Thus neutral long chain amino acid transport in the parotid gland appears to be independent of that in the exocrine pancreas in chronic pancreatitis. This absence of relationship between the parotid gland and the pancreas in pancreatic disease is in contradiction with the demonstration made in animals of an interaction between these two glands. These results, however, are in agreement with the conclusions drawn from the data collected from the saliva test used by several authors.
THE IDENTIFICATION OF SPECIMENS FROM THE OPERATING ROOM
Authors: Willard S. Hastings
Journal: JAMA (1925)

A prominent surgeon who is unusually familiar with laboratory problems, when visiting this hospital recently, showed an unexpected interest in the system employed for the identification of specimens sent from the operating room to the laboratory, and commented on the usual lack of such a plan elsewhere. On having our attention thus drawn to the matter, we have not been able to recall seeing anything of the sort in use in other places and therefore venture a brief description, though it is such an obvious application of methods familiar in other fields that no report of it had previously been contemplated. The opportunities for serious confusion, loss and delays, with consequent damage to the specimen, that may occur between the operating room and the laboratory are too evident to need enumeration. In spite of rather rigid rules intended to keep a specimen and its history sheet together, there were several
Prognosis and Survival in the Aftermath of Hemiplegia
Authors: G. F. Adams, J. D. Merrett
Journal: BMJ (1961)

There are two stages of recovery from a stroke-the fight for life at the onset, and then the struggle to overcome the effects of residual paralysis.Progress in emergency treatment in the first stage has been influenced by the criteria of differential diagnosis and immediate prognosis defined by Aring and Merritt (1935), Millikan and Moersch (1953), and Rankin (1957), and a basis for
Medical Ethics and Morals in a New Age
Authors: Paul S. Rhoads
Journal: JAMA (1968)

The principles of medical ethics have been enunciated through the ages: in the Babylonian Code of Hammurabi 1,750 years before Christ; in the writing of Charoka and Suśruta—Hindu writers of known antiquity; in the writing of Hippocrates, in the teachings of Christ and his disciples; in the writing of Maimonides; and, in modern times, in the Code of Percival in 1792. The physician always sees himself as one who, because of his peculiar relationship with those he serves, has special responsibility: to be competent, to be honest, to hold a patient's life as a sacred trust. Hippocrates said, "A physician should be an upright man, instructed in the art of healing... modest, sober, patient, prompt to do his whole duty without anxiety, pious without going so far as superstition, conducting himself with propriety in his profession and in all the actions of his life."<sup>1</sup> Christ said it for all
Complement and Leukocyte-Mediated Pulmonary Dysfunction in Hemodialysis
Authors: Philip R. Craddock, Jorg Fehr, Kenneth L. Brigham, Richard S. Kronenberg, Harry S. Jacob
Journal: New England Journal of Medicine (1977)

During hemodialysis, cardiopulmonary decompensation may appear in uremic patients, possibly caused by plugging of pulmonary vessels by leukocytes. In 34 patients we noted leukopenia (20% of initial levels) during hemodialysis that in 15 was associated with impaired pulmonary function. When we infused autologous plasma, incubated with dialyzer cellophane, into rabbits and sheep, sudden leukopenia and hypoxia occurred, with doubling of pulmonary-artery pressures and quintupling of pulmonary-lymph effluent. Histologic examination showed severe pulmonary-vessel-leukostasis and interstitial edema. The syndrome was prevented by preinactivation of complement but was reproduced by infusions of plasma in which complement was activated by zymosan. Thus, acute pulmonary dysfunction from complement-mediated leukostasis may play a major part in the acute cardiopulmonary complications of cellophane-membrane hemodialysis.
Pancreatitis-Induced Inflammation Contributes to Pancreatic Cancer by Inhibiting Oncogene-Induced Senescence
Authors: Carmen Guerra, Manuel Collado, Carolina Navas, Alberto J. Schuhmacher, Isabel Hernández-Porras, Marta Cañamero, Manuel Rodriguez-Justo, Manuel Serrano, Mariano Barbacid
Journal: Cancer Cell (2011)
Empirical Coverage of Psychodynamic Configurations of Anorexia nervosa
Authors: Klaus Engel, Gertrud Wigand
Journal: Psychotherapy and Psychosomatics (1989)

For the last several years, the clinical picture of anorexia nervosa has been covered at the following three levels: (1) symptomatology (including partner and family relations); (2) psychodynamics; (3) narcissistic level. As far as the psychodynamic level is concerned, this paper presents the pertinent theory in its operationalized form for a clinical rating. The convergent validity of the five psychodynamic configurations is tested by a comparison of clinical rating, a questionnaire (IATAN) and a standardized interview (SIAN); divergent validity is tested by verifying the mutual differences of the five configurations.
Direct and indirect effects of functionalised fluorescence-labelled nanoparticles on human osteoclast formation and activity
Authors: Andrea Tautzenberger, Ludwika Kreja, Anke Zeller, Steffen Lorenz, Hubert Schrezenmeier, Volker Mailänder, Katharina Landfester, Anita Ignatius
Journal: Biomaterials (2010)
Comparative ultrastructure of late rabbit‐embryo erythroid cells in liver and peripheral blood
Authors: A. Brunner, C. Y. Mitsutani, C. Araújo De Peres
Journal: American Journal of Hematology (1977)

Abstract A morphological study of hemoglobin biosynthesis activity in rabbit‐embryo liver and peripheral blood was comparatively developed. Orthochromatic erythroblasts and reticulocytes of the same maturing degree were analysed through thin sections, as to their organellar constitution and behaviour regarding iron incorporation. It was found that peripheral blood erythroid cells contain mainly hemosomes, organelles taken as sites of final hemoglobin molecule biosynthesis. The ratio between the mean number of hemosomes in blood erythroid cell sections and that in liver erythroid cell sections reaches a little more than 6:1. Inversely, late liver erythroid cells are predominantly constituted by mitochondria that directly or indirectly participate in hemosome formation. The ratio between the mean number of mitochondria in blood erythroid cell sections and that in liver erythroid cell sections reaches 1:11. Besides this, the iron incorporation activity is higher in peripheral blood erythroid cells than in liver erythroblasts and reticulocytes. It is apparent that erythroid cells in the liver accumulate heme, given the ratio of the means of iron incorporation activity per cell to hemosome per cell (3.67), while blood erythroid cells, with a 1.08 ratio, synthesize heme, which is immediately afterwards integrated into the globin chains. The sudden increase in the formation of hemosomes when liver orthochromatic erythroblasts and reticulocytes enter the peripheral blood, reflecting an enhancement of hemoglobin synthesis, agrees with biochemical findings of other authors.
Human somatic cell mutagenesis creates genetically tractable sarcomas
Authors: Sam D Molyneux, Paul D Waterhouse, Dawne Shelton, Yang W Shao, Christopher M Watling, Qing-Lian Tang, Isaac S Harris, Brendan C Dickson, Pirashaanthy Tharmapalan, Geir K Sandve, Xiaoyang Zhang, Swneke D Bailey, Hal Berman, Jay S Wunder, Zsuzsanna Izsvák, Mathieu Lupien, Tak W Mak, Rama Khokha
Journal: Nature Genetics (2014)
Shall the Physician Act as Clerk for an Insurance Company without Pay?
Authors: J. Noer
Journal: JAMA (1895)

Stoughton,Wis., April 11, 1895.  To the Editor:  —I inclose a copy of a letter I wrote to the Wisconsin Benevolent Association which is self-explanatory: Wisconsin Benevolent Association, Milwaukee, Wis .  Gentlemen:  —Your letter of the 11th inst. at hand. Your statement does not in the least alter the position I have taken.  I filled out the blank sent to the patient, giving my diagnosis, number of visits, date of first and last visits, the time patient was confined to the house, etc. This is about all that is required of the attending physician, without compensation, by any legitimate accident insurance company and is amply sufficient to establish the justice of the claim so far as the testimony of the attending physician is concerned.  The filling out of a complicated blank, such as you inclose, requires time and technical skill, is exclusively for your benefit, and is not under any consideration
The relationship between the fibrinogen D domain self-association/cross-linking site (gammaXL) and the fibrinogen Dusart abnormality (Aalpha R554C-albumin): clues to thrombophilia in the "Dusart syndrome".
Authors: M W Mosesson, K R Siebenlist, J f Hainfeld, J S Wall, J Soria, C Soria, J P Caen
Journal: Journal of Clinical Investigation (1996)

Cross-linking of fibrinogen at its COOH-terminal gamma chain cross-linking site occurs in the presence of factor XIIIa due to self-association at a constitutive D domain site ("gammaXL"). We investigated the contribution of COOH-terminal regions of fibrinogen Aalpha chains to the gammaXL site by comparing the gamma chain cross-linking rate of intact fibrinogen (fraction I-2) with that of plasma fraction I-9, plasmic fraction I-9D, and plasmic fragment D1, which lack COOH-terminal Aalpha chain regions comprising approximately 100, approximately 390, and 413 residues, respectively. The cross-linking rates were I-2 > I-9 > 1-9D = D1, and indicated that the terminal 100 or more Aalpha chain residues enhance gammaXL site association. Fibrinogen Dusart, whose structural abnormality is in the COOH-terminal "alphaC" region of its Aalpha chain (Aalpha R554C-albumin), is associated with thrombophilia ("Dusart Syndrome"), and is characterized functionally by defective fibrin polymerization and clot structure, and reduced plasminogen binding and tPA-induced fibrinolysis. In the presence of XIIIa, the Dusart fibrinogen gamma chain cross-linking rate was about twice that of normal, but was normalized in proteolytic fibrinogen derivatives lacking the Aalpha chain abnormality, as was reduced plasminogen binding. Electron microscopy showed that albumin-bound Dusart fibrinogen "alphaC" regions were located in the vicinity of D domains, rather than at their expected tethered location near the fibrinogen E domain. In addition, there was considerable fibrinogen aggregation that was attributable to increased intermolecular COOH-terminal Aalpha chain associations promoted by untethered Dusart fibrinogen aC domains. We conclude that enhanced Dusart fibrinogen self-assembly is mediated through its abnormal alphaC domains, leads to increased gammaXL self-association and gamma chain cross-linking potential, and contributes to the thrombophilia that characterizes the "Dusart Syndrome."
Predictors of response to reinduction chemotherapy for patients with acute myeloid leukemia who do not achieve complete remission with frontline induction chemotherapy
Authors: Joseph M. Brandwein, Vikas Gupta, Andre C. Schuh, Aaron D. Schimmer, Karen Yee, Wei Xu, Hans A. Messner, Jeffrey H. Lipton, Mark D. Minden
Journal: American Journal of Hematology (2007)

Abstract Eighty‐one patients with acute myeloid leukemia who had persistent leukemia following standard induction therapy with cytarabine plus daunorubicin (7+3 regimen) underwent reinduction therapy with a combination of mitoxantrone, etoposide, and high‐dose cytarabine (HiDAC). Patients achieving complete remission (CR) then received consolidation therapy with HiDAC plus mitoxantrone. Patients with matched sibling donors were referred for allogeneic bone marrow transplantation (BMT) in CR‐1. The overall response rate to reinduction was 53%. The major adverse predictors of CR on multivariate analysis were poor risk cytogenetics, a higher % bone marrow blasts prior to reinduction therapy and increased age. The median relapse‐free survival (RFS) was 9 months and the estimated 2‐year RFS was 30%. No significant predictors of RFS or overall survival (OS) were found among the patients achieving CR. Patients undergoing allogeneic BMT in CR‐1 after double induction had a 50% 2‐year OS. Patients relapsing after achieving CR with double induction had a poor outcome with a 4% 1‐year OS. The results indicate that patients with poor risk cytogenetics or marrow blast percentage ≥ 60% following 7+3 induction have a low probability of achieving CR with reinduction and should be considered for novel approaches to improve CR rates. Patients achieving CR are at high risk of relapse and should be considered for allogeneic BMT or novel strategies to attempt to reduce relapse rates. Am. J. Hematol., 2008. © 2007 Wiley‐Liss, Inc.
Say No to DMSO: Dimethylsulfoxide Inactivates Cisplatin, Carboplatin, and Other Platinum Complexes
Authors: Matthew D. Hall, Katherine A. Telma, Ki-Eun Chang, Tobie D. Lee, James P. Madigan, John R. Lloyd, Ian S. Goldlust, James D. Hoeschele, Michael M. Gottesman
Journal: Cancer Research (2014)

Abstract The platinum drugs cisplatin, carboplatin, and oxaliplatin are highly utilized in the clinic and as a consequence are extensively studied in the laboratory setting. In this study, we examined the literature and found a significant number of studies (11%–34%) in prominent cancer journals utilizing cisplatin dissolved in DMSO. However, dissolving cisplatin in DMSO for laboratory-based studies results in ligand displacement and changes to the structure of the complex. We examined the effect of DMSO on platinum complexes, including cisplatin, carboplatin, and oxaliplatin, finding that DMSO reacted with the complexes, inhibited their cytotoxicity and their ability to initiate cell death. These results render a substantial portion of the literature on cisplatin uninterpretable. Raising awareness of this significant issue in the cancer biology community is critical, and we make recommendations on appropriate solvation of platinum drugs for research. Cancer Res; 74(14); 3913–22. ©2014 AACR.
Endoscopy is useful during percutaneous tracheostomy
Authors: P. Jefferson
Journal: BMJ (2002)

EDITOR—Percutaneous tracheostomy is now well established in intensive care units in the United Kingdom.1 Routine use of endoscopy during this procedure is less well established, and Susanto's comment that most percutaneous tracheostomies are done under endoscopic guidance requires comment.2 A survey of intensive care units in …
Respiratory Gating Techniques for Optimization of Lung Cancer Radiotherapy
Authors: Philippe Giraud, Esra Morvan, Line Claude, Françoise Mornex, Cécile Le Pechoux, Jean-Marc Bachaud, Pierre Boisselier, Véronique Beckendorf, Magali Morelle, Marie-Odile Carrère
Journal: Journal of Thoracic Oncology (2011)
Equity in maternal, newborn, and child health interventions in Countdown to 2015: a retrospective review of survey data from 54 countries
Authors: Aluísio JD Barros, Carine Ronsmans, Henrik Axelson, Edilberto Loaiza, Andréa D Bertoldi, Giovanny VA França, Jennifer Bryce, J Ties Boerma, Cesar G Victora
Journal: The Lancet (2012)
Israeli women can buy ova from abroad
Authors: J. Siegel-Itzkovich
Journal: BMJ (2002)

Infertile Israeli women are to be allowed to import ova from other countries, after the government reversed a six month old ban on the import of human eggs. The reversal followed action by about 90 women who were waiting for ova and who petitioned the High Court of Justice for an end to the ban.

The women will be allowed to pay for the imported ova, making it …
Patent Umbilical Vein
Authors: JOHN C. GOUSE, BRIAN R. J. WILLIAMSON, VALERIE A. BROOKEMAN, CHARLES D. TEATES
Journal: Clinical Nuclear Medicine (1987)

Abdominal scanning with Tc-99m labeled red blood cells serendipitously demonstrated collateral flow in a patent umbilical vein in a patient with unsuspected advanced cirrhotic liver disease and portal hypertension. Knowledge of this was crucial in planning the optimal surgical approach in this patient, referred for resection of a bladder carcinoma. Furthermore, the nuclide study was helpful in clarifying several questions posed by a prior abdominal pelvic CT scan.
EFFECT OF BENZEDRINE SULPHATE ALTERNATED WITH SODIUM AMYTAL IN SCHIZOPHRENIA
Authors: LEON REZNIKOFF
Journal: American Journal of Psychiatry (1941)

1. Administration of benzedrine sulphate and sodium amytal on alternating days cannot be recommended as a therapeutic procedure for schizophrenia. 2. While the author is not enthusiastic about results obtainable with metrazol shock therapy in schizophrenia because of the definitely temporary nature of improvement when it does occur, and the serious complications, the results obtained from the trial with benzedrine and amytal, when compared with metrazol shock, were not only considerably inferior but practically negligible. 3. Intravenous injections of large doses of benzedrine sulphate (30 mg.) every other day for a month to young, physically healthy adults caused no harmful effects of permanent nature.
Opportunistic chlamydia screening in a general practice consultation
Authors: S. A. Kalwij
Journal: BMJ (2011)

A 24 year old woman was offered opportunistic chlamydia screening during a routine general practice appointment for another problem. It is practice protocol to offer a test for chlamydia to all patients under the age 25, and clinicians are alerted to this with a computer prompt. She had a 3 year old son but was no longer in a relationship with the father. She had been in a new relationship for the past eight months, however, and said that she occasionally used condoms in addition to oral contraception. She had been tested for chlamydia when she was pregnant but the result was negative. She accepted the screening offer and provided a self collected lower vaginal swab, which she collected in the practice toilet during the consultation. Two days later her result came back positive and she was invited back to the practice for further discussion and treatment.



### 1 Why is screening for chlamydia important in patients under the age of 25?

#### Short answer

The prevalence of chlamydia is highest in young people under the age of 25.

#### Long answer

The National Chlamydia Screening Programme recommends that all people under the age of 25 who are sexually active should be tested for chlamydia at least once a year or after a change in sexual partner. An infection with chlamydia can occur at any age but is most common in people under the age of 25,1 with rates of diagnosis peaking in women aged 16-19 and men aged 20-24.2

### 2 What complications may follow chlamydial infection?

#### Short answer

Infections with chlamydia can cause ectopic pregnancy and tubal infertility, epididymitis, pelvic inflammatory disease, chronic lower abdominal or pelvic …
Angiopoietin-2 expression in B-cell chronic lymphocytic leukemia: association with clinical outcome and immunoglobulin heavy-chain mutational status
Authors: R Maffei, R Marasca, S Martinelli, I Castelli, R Santachiara, E Morandi, P Zucchini, M Fontana, F Giacobbi, P Silingardi, G Bonacorsi, P Temperani, L Masini, A M Colacci, R Serra, G Torelli
Journal: Leukemia (2007)
Extensive F-18 FDG Uptake in Metastatic Spindle Cell Carcinoma of the Lung
Authors: JEAN VERREAULT, ERIC TURCOTTE, FRANÇOIS BENARD, CHARLES JACQUES MONGEAU, ROBERT BOILEAU
Journal: Clinical Nuclear Medicine (2001)

A 77-year-old man with stage IIB squamous cell carcinoma of the lung underwent right upper lobectomy. One month later he was examined for right chest pain, dyspnea, cough, and weakness. A roentgenogram showed nondiagnostic diffuse opacification of his right lung cavity. An F-18 FDG positron emission tomographic (PET) study revealed extensive uptake in the right pleural area, left adrenal gland, right axilla, and soft tissues consistent with extensive local recurrence and metastatic disease. Biopsy of a right chest soft tissue lesion showed spindle cell carcinoma, a rare variant of squamous cell carcinoma.