THE SOURCE OF SULFATHIAZOLE HEMATURIA INDUCED IN RABBITS.
Authors: Gordon I. Trevett, S. S. Blackman
Journal: Annals of Internal Medicine (1944)

Article1 June 1944THE SOURCE OF SULFATHIAZOLE HEMATURIA INDUCED IN RABBITS.GORDON I. TREVETT, M.D., S. S. BLACKMAN JR., M.D.GORDON I. TREVETT, M.D.Search for more papers by this author, S. S. BLACKMAN JR., M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-20-6-971 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptIt is known that sulfonamide drug therapy may be complicated by the precipitation of crystals or the formation of concretions in the urinary tract. Considerable evidence has been presented indicating that these crystals may be responsible for the anuria, azotemia and hematuria encountered during sulfonamide therapy. The possibility that these drugs may induce hematuria through some toxic action on the glomeruli has not been excluded.It seemed advisable to determine the source of hematuria in experimental animals and to establish the relative frequency of these two potential sources. At autopsy glomerular bleeding would be indicated by the presence of red...Bibliography1. COOPERGROSSLEWIS FBPM: Chemotherapeutic evaluation of sulfanilamide derivatives of heterocyclic amines, Proc. Soc. Exper. Biol. and Med., 1939, xlii, 421. CrossrefGoogle Scholar2. RAKEVAN DYKECORWINMCKEEGREEP GHBWCCMRO: Pathological changes following prolonged administration of sulfathiazole and sulfapyridine, Jr. Bact., 1940, xxix, 45. Google Scholar3. RAKEVAN DYKECORWIN GHBWC: Pathological changes following prolonged administration of sulfathiazole and sulfapyridine, Am. Jr. Med. Sci., 1940, cc, 353. Google Scholar4. 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Author, Article, and Disclosure InformationAffiliations: Baltimore, Maryland*Received for publication July 14, 1943.From the Department of Preventive Medicine and the Department of Pathology of The Johns Hopkins University, Baltimore, Maryland.This study was supported by a grant from the John and Mary R. Markle Foundation, New York City.†Winthrop Chemical Company Fellow; deceased May 4, 1944. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byOn the Risk of Urolith Formation in Treatment with Sulfa Preparations.Kidney Complications during Sulphonamide Therapy1 1 June 1944Volume 20, Issue 6Page: 971-980KeywordsAutopsyDrug therapyDrugsHemorrhagePreventive medicineRabbitsSulfonamide ePublished: 1 December 2008 Issue Published: 1 June 1944 PDF downloadLoading ...