tbuckley/cabot-search huggingface dataset:
Characterization of the Cartilage DNA Methylome in Knee and Hip Osteoarthritis
Authors: Michael D. Rushton, Louise N. Reynard, Matt J. Barter, Ramsay Refaie, Kenneth S. Rankin, David A. Young, John Loughlin
Journal: Arthritis & Rheumatology (2014)

The aim of this study was to characterize the genome-wide DNA methylation profile of chondrocytes from knee and hip cartilage obtained from patients with osteoarthritis (OA) and hip cartilage obtained from patients with femoral neck fracture, providing the first comparison of DNA methylation between OA and non-OA hip cartilage, and between OA hip and OA knee cartilage.The study was performed using the Illumina Infinium HumanMethylation450 BeadChip array, which allows the annotation of ∼480,000 CpG sites. Genome-wide methylation was assessed in chondrocyte DNA extracted from 23 hip OA patients, 73 knee OA patients, and 21 healthy hip control patients with femoral neck fracture.Analysis revealed that chondrocytes from the hip cartilage of OA patients and healthy controls have unique methylation profiles, with 5,322 differentially methylated loci (DMLs) identified between the 2 groups. In addition, a comparison between hip and knee OA chondrocytes revealed 5,547 DMLs between the 2 groups, including DMLs in several genes known to be involved in the pathogenesis of OA. Hip OA samples were found to cluster into 2 groups. A total of 15,239 DMLs were identified between the 2 clusters, with an enrichment of genes involved in inflammation and immunity. Similarly, we confirmed a previous report of knee OA samples that also clustered into 2 groups.We demonstrated that global DNA methylation using a high-density array can be a powerful tool in the characterization of OA at the molecular level. Identification of pathways enriched in DMLs between OA and OA-free cartilage highlight potential etiologic mechanisms that are involved in the initiation and/or progression of the disease and that could be therapeutically targeted.
Relationship Between C-Reactive Protein Levels and Regional Left Ventricular Function in Asymptomatic Individuals
Authors: Boaz D. Rosen, Mary Cushman, Khurram Nasir, David A. Bluemke, Thor Edvardsen, Verônica Fernandes, Shenghan Lai, Russell P. Tracy, João A.C. Lima
Journal: Journal of the American College of Cardiology (2007)
REGIONAL ILEITIS INVOLVING THE ILEUM, CECUM, ASCENDING COLON, AND TRANSVERSE COLON
Authors: I. I. Cash, L. S. Pilcher, A. E. Rappoport, W. A. Barker
Journal: Annals of Internal Medicine (1946)

Case Reports1 August 1946REGIONAL ILEITIS INVOLVING THE ILEUM, CECUM, ASCENDING COLON, AND TRANSVERSE COLONI. I. CASH, L. S. PILCHER, A. E. RAPPOPORT, W. A. BARKERI. I. CASHSearch for more papers by this author, L. S. PILCHERSearch for more papers by this author, A. E. RAPPOPORTSearch for more papers by this author, W. A. BARKERSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-25-2-351 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptSince 1932 when Crohn, Ginzburg, and Oppenheimer1first published their paper on 13 cases showing necrotizing cicatricial inflammation of the terminal ileum, many reports have appeared in the literature on the subject of granulomatous ileocolitis, commonly called "regional ileitis." Reports of cases showing widespread involvement of the cecum, ascending and transverse colon, as well as of the terminal ileum are uncommon. Bockus and his associates report 21 cases of regional ileocolitis,2seven of which showed involvement of terminal ileum and colon proximal to the sigmoid. Ravdin and Johnston3in a summary of the literature tabulate 10 instances in a series...Bibliography1. CROHNGINZBURGOPPENHEIMER BBLGD: Regional ileitis, Jr. Am. Med. Assoc., 1932, xcix, 1323. CrossrefGoogle Scholar2. BOCKUS HL: Gastro-enterology, Volume II, 1944, W. B. Saunders Company, Philadelphia, p. 159. Google Scholar3. RAVDINJOHNSTON ISCG: Regional ileitis: a summary of the literature, Am. Jr. Med. Sci., 1939, cxcviii, 269. CrossrefGoogle Scholar4. FELSEN J: New concepts of bacillary dysentery; its relationship to non-specific colitis, distal ileitis and non-specific granuloma, Am. Jr. Digest. Dis. and Nutr., 1936, iii, 86. CrossrefGoogle Scholar5. MARSHALL SF: Regional ileitis: surgical management and results of operation, Surg. Clin. North Am., 1943, p. 873. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: *Received for publication May 29, 1945. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byDiarrhea and Constipation 1 August 1946Volume 25, Issue 2Page: 351-362KeywordsCecumColonIleumInflammation ePublished: 1 December 2008 Issue Published: 1 August 1946 PDF downloadLoading ...
Factors associated with severity of occupational asthma with a latency period at diagnosis
Authors: A. Descatha, H. Leproust, D. Choudat, R. Garnier, J.‐C. Pairon, J. Ameille
Journal: Allergy (2007)

Background: Severity of occupational asthma at diagnosis is an important prognostic factor. The aim of this study was to determine which factors affect the severity of occupational asthma with a latency period at diagnosis. Methods: The study population consisted of 229 consecutive subjects with occupational asthma with a latency period recruited by four occupational health departments and divided into two groups according to the severity of the disease at diagnosis. The moderate‐severe (FEV 1 &lt;70% predicted, or PD 20 methacholine ≤300 μg; n = 101) and mild (FEV 1 ≥70% predicted and PD 20 methacholine &gt;300 μg, n = 128) groups were compared in terms of clinical and demographic parameters. Multivariate analysis using logistic regressions was performed to examine factors associated with asthma severity. Results: Duration of symptoms before diagnosis was significantly longer in the moderate‐severe group (mean ± SD: 6.3 ± 6.8 years vs 3.4 ± 4.4 years, P &lt; 0.001). Sex ratio, age, atopy, smoking habits, duration of exposure before symptoms, and molecular weight of the causal agent were not significantly different between the two groups. On multivariate analysis, only duration of symptoms before diagnosis was associated with asthma severity (aOR = 1.12, 95% CI 1.05–1.18, P &lt; 0.001). Conclusions: Severity of occupational asthma with a latency period at diagnosis was associated with duration of symptoms before diagnosis, but not with the type of causal agent. This finding emphasizes the need for early diagnosis and avoidance of exposure.
Abstract 5577: Complement Component 3a Receptor (C3aR) Attenuates Atherosclerosis Development
Authors: Izabela Rozenberg, Susanna H Sluka, Ulrich Wagner, Thomas F Luscher, Felix C Tanner
Journal: Circulation (2009)

Up-to-date molecular biological methods permit efficient identification and characterization of new genes. Using Affimetrix microarrays, we studied gene expression in thoracic aorta of ApolipoproteinE − / − ( ApoE − / − ) animals fed either a normal or a high cholesterol diet (HCD) for 4 weeks. Over 200 genes were differentially regulated under these conditions. Interestingly, most components of the complement pathway were upregulated after a HCD, with the complement component 3a receptor (C3aR) exhibiting the highest induction. To study the relevance of the complement pathway in atherogenesis, ApoE − / − C3aR − / − mice and ApoE − / − controls were compared after 12 weeks of a HCD. ApoE − / − C3aR − / − animals had on average 14.11%±3.16% of descending aortas occupied by atherosclerotic plaques, which was nearly 2-fold more than controls (7.11%±1.01%). This effect was associated with increased accumulation of leukocytes in atherosclerotic plaques of ApoE − / − C3aR − / − mice. Moreover, production of the proinflammatory cytokines interferon gamma (IFN γ ), chemokine (C-C) ligand-5 (CCL5), tumor necrosis factor beta (TNF β ), interleukin-12 (IL-12), and interleukin-18 (IL-18) was higher upon C3aR deletion. This study demonstrates that C3aR protects from atherosclerosis development, emphasizing the complex role of the complement cascade in the development of inflammation during atherogenesis.
Abstract P067: Nut Consumption is Associated with a Lower Risk of Death among US Male Physicians
Authors: Luc Djousse, Andrew Petrone, John Gaziano
Journal: Circulation (2014)

Background: Previous studies have suggested that nut consumption, a good source of unsaturated fatty acids, magnesium, potassium, fiber, antioxidants, and vitamins is associated with a lower risk of coronary heart disease, type 2 diabetes, and sudden cardiac death. However, limited data are available on the association between nut intake and all-cause mortality. Objective: To test the hypothesis that nut consumption is inversely associated with the risk of all-cause mortality. Methods: A prospective cohort study of 20,742 male physicians from the Physicians’ Health Study. Nut intake was assessed between 1999 and 2002 using a food frequency questionnaire and deaths were ascertained by an endpoint committee. We used Cox regression to estimate multivariable adjusted relative risk of death according to nut consumption. In secondary analyses, we evaluated associations of nut consumption with cause-specific mortality (coronary heart disease, stroke, and cancer deaths). Results: During a median follow-up of 9.5 years, there were 2,732 deaths. The mean age at baseline was 66.6 ± 9.3 years. Median intake of nuts was 1 time per week. Multivariable adjusted hazard ratios (95% CI) were: 1.0 (ref), 0.91 (0.83-1.00), 0.85 (0.76-0.95), 0.86 (0.75-0.98), and 0.74 (0.63-0.87) for nut consumption of never, 1-3/month, 1/week, 2-4/week, and 5+/week, respectively (p for linear trend &lt;0.0001), after adjustment for age, body mass index, alcohol use, smoking, exercise, energy intake, saturated fat, fruit and vegetables, red meat intake, and prevalent diabetes and hypertension. In a secondary analysis, nut intake was inversely related to CVD death; however, only a suggestive and non-statistically significant relation was seen for cancer mortality (Table). Conclusions: Our data are consistent with an inverse association between nut consumption and risk of all-cause mortality in US male physicians.
The Nature of Aggression during Epileptic Seizures
Authors: Antonio V. DelgadoEscueta, Richard H. Mattson, Lambert King, Eli S. Goldensohn, Herbert Spiegel, Jack Madsen, Paul Crandall, Fritz Dreifuss, Roger J. Porter
Journal: New England Journal of Medicine (1981)

Since 1889, there have been only 15 appellate cases in the United States in which epilepsy has been used as a defense against charges of murder, homicide, manslaughter, or disorderly conduct. Recently, medical investigators have implied a causal relation between temporal-lobe epilepsy and violence.1 2 3 As a result, epileptic automatisms have been used as part of the "diminished legal responsibility" or "insanity" defense against at least 12 charges of crimes of violence since 1977. In 1979 alone, five cases of murder went to court with epilepsy as the defense. Because these criminal cases have had undue attention in the lay press, . . .
As West Nile Virus Season Heats Up, Blood Safety Testing Lags Behind
Authors: Mike Mitka
Journal: JAMA (2003)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2022 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
THE ELECTROCARDIOGRAM IN CONGENITAL HEART DISEASE (A POSTMORTEM CORRELATION STUDY OF 53 CASES
Authors: M H UHLEY
Journal: Annals of Internal Medicine (1950)

Excerpt Recently there has been a renewed interest in congenital heart disease. The use of chamber catheterization,1, 2angiocardiography3, 4, 5, 6, 7, 8and the establishment of definitive fluorosco...
CASE REPORT OF URINARY OBSTRUCTION DUE TO CRYSTALLINE CONCRETIONS FOLLOWING SULFAPYRIDINE THERAPY IN PNEUMONIA
Authors: M. M. Scurry, M. H. Wittenborg
Journal: Annals of Internal Medicine (1940)

Case Reports1 May 1940CASE REPORT OF URINARY OBSTRUCTION DUE TO CRYSTALLINE CONCRETIONS FOLLOWING SULFAPYRIDINE THERAPY IN PNEUMONIAM. M. SCURRY, M.D., M. H. WITTENBORG, M.D.M. M. SCURRY, M.D.Search for more papers by this author, M. H. WITTENBORG, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-13-11-2164 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThis case report is presented in confirmation of the observation that urinary obstruction may occur during the course of sulfapyridine therapy as a result of the formation of sulfapyridine concretions in the urinary tract. A similar case, which yielded promptly to treatment, has recently been reported by Carroll, Shea and Pike.1Many reports of gross hematuria following the administration of this drug have appeared in the literature. The occurrence of blood in the urine, under these circumstances, was at first ascribed to a "toxic nephritis." Evidence against this is the character of the abnormal urinary findings and the fact that...Bibliography1. CARROLLSHEAPIKE GJG: Complete anuria due to crystalline concretions following the use of sulfapyridine in pneumonia, Jr. Am. Med. Assoc., 1940, cxiv, 411-412. Google Scholar2. GROSSCOOPERLEWIS PFBM: Urinary calculi caused by sulfapyridine, Urol. and Cutan. Rev., 1939, xliii, 299-302. Google Scholar3. ANTOPOLROBINSON WH: Urolithiasis and renal pathology after oral administration of 2 (sulfanilylamino) pyridine (sulfapyridine), Proc. Soc. Exper. Biol. and Med., 1939, xl, 428-430. CrossrefGoogle Scholar4. SOUTHWORTHCOOKE HC: Hematuria, abdominal pain and nitrogen retention associated with sulfapyridine, Jr. Am. Med. Assoc., 1939, cxii, 1820-1821. Google Scholar5. SNAPPER I: Hematuria, renal colic and acetylsulfapyridine stone formation associated with sulfapyridine therapy, Chinese Med. Jr., 1939, lvi, 1-10. Google Scholar6. TSAOMCCRACKENCHENKUODALE YFMFJPTCL: Renal complication in sulfapyridine therapy, Jr. Am. Med. Assoc., 1939, cxiii, 1316-1319. CrossrefGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Ann Arbor, Michigan*Received for publication March 8, 1940.From the Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 May 1940Volume 13, Issue 11Page: 2164-2166KeywordsBloodDrug administrationDrugsNephritisPneumoniaUrine ePublished: 1 December 2008 Issue Published: 1 May 1940 PDF downloadLoading ...
Clinical, histopathological and immunohistochemical assessment of human skin field cancerization before and after photodynamic therapy
Authors: R.M. Szeimies, L. Torezan, A. Niwa, N. Valente, P. Unger, E. Kohl, S. Schreml, P. Babilas, S. Karrer, C. Festa-Neto
Journal: British Journal of Dermatology (2012)

The field cancerization concept in photodamaged patients suggests that the entire sun-exposed surface of the skin has an increased risk for the development of (pre)-malignant lesions, mainly epithelial tumours. Topical photodynamic therapy (PDT) is a noninvasive therapeutic method for multiple actinic keratosis (AK) with excellent outcome.To evaluate the clinical, histological and immunohistochemical changes in human skin with field cancerization after multiple sessions of PDT with methyl-aminolaevulinate (MAL).Twenty-six patients with photodamaged skin and multiple AK on the face received three consecutive sessions of MAL-PDT with red light (37 J cm(-2)), 1 month apart. Biopsies before and 3 months after the last treatment session were taken from normal-appearing skin on the field-cancerized area. Immunohistochemical stainings were performed for TP-53, procollagen-I, metalloproteinase-1 (MMP-1) and tenascin-C (Tn-C).All 26 patients completed the study. The global score for photodamage improved considerably in all patients (P < 0·001). The AK clearance rate was 89·5% at the end of the study. Two treatment sessions were as effective as three MAL-PDT sessions. A significant decrease in atypia grade and extent of keratinocyte atypia was observed histologically (P < 0·001). Also, a significant increase in collagen deposition (P = 0·001) and improvement of solar elastosis (P = 0·002) were noticed after PDT. However, immunohistochemistry showed only a trend for decreased TP-53 expression (not significant), increased procollagen-I and MMP-1 expressions (not significant) and an increased expression of Tn-C (P = 0·024).Clinical and histological improvement in field cancerization after multiple sessions of MAL-PDT is proven. The decrease in severity and extent of keratinocyte atypia associated with a decreased expression of TP-53 suggest a reduced carcinogenic potential of the sun-damaged area. The significant increase of new collagen deposition and the reduction of solar elastosis explain the clinical improvement of photodamaged skin.
Abstract 13917: Metastasis-associated Protein S100A4 Contributes to Cardiac Fibrosis through the Modulation of PTEN
Authors: Yodo Tamaki, Yoshitaka Iwanaga, Junji Okuda, Shinichiro Niizuma, Tsuneaki Kawashima, Takao Kato, Yasutaka Inuzuka, Tetsuo Shioi, Koh Ono, Taka-aki Koshimizu, Shunichi Miyazaki, Toru Kita, Takeshi Kimura
Journal: Circulation (2010)

Background: The calcium-binding protein S100A4 possesses a wide range of biological functions and promotes metastasis. Recently, in non-cancer diseases such as kidney diseases, liver fibrosis and r...
Atypical ichthyosiform erythroderma, deafness and keratitis.
Authors: R.J.G. RYCROFT, E.J. MOYNAHAN, R.S. WELLS
Journal: British Journal of Dermatology (1976)

Two patients with ichthyosiform erythroderma of the same unusual but characteristic distribution are described. Both patients were born with perceptive deafness and developed severe vascularizing keratitis in early childhood. There is no family history of the disorder in either case. This syndrome is discussed in relation to previous reports of atypical ichthyosiform erythroderma associated with deafness.
Systolic and Diastolic Ventricular Dyssynchrony in Systolic and Diastolic Heart Failure⁎⁎Editorials published in the Journal of the American College of Cardiologyreflect the views of the authors and do not necessarily represent the views of JACCor the American College of Cardiology.
Authors: John E. Sanderson
Journal: Journal of the American College of Cardiology (2006)
Abstract 2667: RG7287, a novel humanized anti-CDCP1 antibody with superior preclinical <i>in vivo</i> efficacy in combination with Paclitaxel
Authors: Gwendlyn Kollmorgen, Alexander Lifke, Adam Nopora, Frieder Bauss, Gerhard Niederfellner, Birgit Bossenmaier
Journal: Cancer Research (2014)

Abstract CUB domain-containing protein 1 (CDCP1) is a transmembrane glycoprotein and a substrate of Src family kinase (SFK). It has been shown to be upregulated and significantly contributing to a number of different cancers, including colon, lung, breast, kidney, and pancreas cancer. High expression of CDCP1 has been shown to correlate with poor prognosis. CDCP1 is involved in the regulation of anoikis resistance, cell migration and invasion. We have recently described RG7287, a humanized glycoengineered therapeutic anti-CDCP1 antibody with a dual mode of action. (1) downregulation of the receptor from the cell surface, and (2) engaging immune effector functions such as antibody-dependent cellular cytotoxicity (ADCC). Upon ligation of RG7287 to CDCP1 an initial phosphorylation of CDCP1 occurs, this transient activation results in the down-regulation of CDCP1. RG7287 prohibits the transformation potential of CDCP1 and Src in focus formation assays. In vivo, RG7287 increased the survival time of mice bearing tumors of MCF7 cells stably expressing CDCP1 compared to untreated CDCP1 overexpressing MCF7 tumors. Treatment of three different xenograft models with RG7287 inhibited tumor growth. In this study we looked at the possibility of eradicating the tumors by combining RG7287 with paclitaxel. Combining the cytostatic with RG7287 increases tumor growth inhibition compared to RG7287 alone in one xenograft model. In another model the combination of RG7287 with paclitaxel leads to tumor stasis. These results indicate a potential combination therapy for RG7287. We also tested whether RG7287 inhibits metastasis in vivo. Using a metastasis model we could show convincing inhibition of metastasis. Citation Format: Gwendlyn Kollmorgen, Alexander Lifke, Adam Nopora, Frieder Bauss, Gerhard Niederfellner, Birgit Bossenmaier. RG7287, a novel humanized anti-CDCP1 antibody with superior preclinical in vivo efficacy in combination with Paclitaxel. [abstract]. In: Proceedings of the 105th Annual Meeting of the American Association for Cancer Research; 2014 Apr 5-9; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2014;74(19 Suppl):Abstract nr 2667. doi:10.1158/1538-7445.AM2014-2667
Lenvatinib in Radioiodine-Refractory Thyroid Cancer
Authors: Martin Schlumberger, Makoto Tahara, Lori J Wirth
Journal: New England Journal of Medicine (2015)

To the Editor: Schlumberger et al. (Feb. 12 issue) 1 report that lenvatinib, as compared with placebo, showed significant improvements in progression-free survival and response rate among patients with radioiodine-refractory thyroid cancer. However, 76% of the patients had grade 3 or higher treatment-related toxic events, and there were an increased number of deaths during lenvatinib treatment. Furthermore, 6 of the 20 deaths in the lenvatinib group appeared to be treatment-related. Therefore, it is crucial to identify predictive biomarkers to identify patients who will benefit most from lenvatinib treatment. These markers might be found at the genetic level, 2 although the presence of BRAF or RAS mutations did not predict a benefit for lenvatinib in this study. 1 Alternatively, the occurrence of adverse events might act as a surrogate biomarker of drug activity because the occurrence of treatment-related toxic effects is associated with pharmacodynamic effects of the drug. 2-4 Recently, it has been suggested that such factors as tumor shrinkage and a severe grade of hypertension, proteinuria, and fatigue induced by lenvatinib were significantly correlated with the area under the curve for the dosing interval. 5 Therefore, it would be interesting to know whether the authors found a correlation between adverse events and treatment outcome.