tbuckley/cabot-search huggingface dataset:
Review: The effect of audit and feedback on guideline adherence and patient outcomes is limited
Authors: Carl van Walraven
Journal: Annals of Internal Medicine (2013)

ACP Journal Club19 February 2013Review: The effect of audit and feedback on guideline adherence and patient outcomes is limitedCarl van Walraven, MD, FRCPC, MScCarl van Walraven, MD, FRCPC, MScUniversity of Ottawa/Ottawa Hospital Research Institute, Ottawa, Ontario, Canada (C.V.W.)Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-158-4-201302190-02011 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail Source CitationIvers N, Jamtvedt G, Flottorp S, et al. Audit and feedback: effects on professional practice and healthcare outcomes. Cochrane Database Syst Rev. 2012;(6):CD000259. https://pubmed.ncbi.nlm.nih.gov/22696318Clinical Impact RatingsGIM/FP/GP: References1 van Walraven C, Austin P, Forster AJ. Urgent readmission rates can be used to infer differences in avoidable readmission rates between hospitals. J Clin Epidemiol. 2012;65:1124-30. [PMID: 22809617] Google Scholar2 van Walraven C, Oake N, Coyle D, Taljaard M, Forster AJ. Changes in surrogate outcomes can be translated into clinical outcomes using a Monte Carlo model. J Clin Epidemiol. 2009;62:1306-15. [PMID: 19545974] Google Scholar Author, Article, and Disclosure InformationAuthors: Carl van Walraven, MD, FRCPC, MScAffiliations: University of Ottawa/Ottawa Hospital Research Institute, Ottawa, Ontario, Canada (C.V.W.)This article was published at Annals.org on 5 February 2013. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byDutch women in midwife-led care at the onset of labour: which pain relief do they prefer and what do they use? 19 February 2013Volume 158, Issue 4Page: JC11KeywordsBehaviorGrading of Recommendations Assessment Development and EvaluationHealth careHealth care providersInterquartile rangeMethicillin-resistant staphylococcus aureusPatientsResidencyRisk managementSystematic reviews ePublished: 19 February 2013 Issue Published: 19 February 2013 Copyright & PermissionsCopyright © 2013 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
LONG–TERM OUTCOMES OF BIODEGRADABLE STENTS IN DIABETES: UPDATED POOLED ANALYSIS OF OUTCOMES VERSUS DURABLE POLYMER SIROLIMUS–ELUTING STENTS
Authors: Lamin King, Antionette de Waha, Giuio Stefanini, Robert A. Byrne, Bernhard Meier, Adnan Kastrati, Stephan Windecker
Journal: Journal of the American College of Cardiology (2013)
Highly efficient endosomal labeling of progenitor and stem cells with large magnetic particles allows magnetic resonance imaging of single cells
Authors: Kathleen A. Hinds, Jonathan M. Hill, Erik M. Shapiro, Mikko O. Laukkanen, Alfonso C. Silva, Christian A. Combs, Timothy R. Varney, Robert S. Balaban, Alan P. Koretsky, Cynthia E. Dunbar
Journal: Blood (2003)
True Incidence of Pulmonary Embolization and Vital Statistics
Authors: Isadore Rossman
Journal: JAMA (1974)

The discrepancy between autopsy incidence and vital statistics reporting for fatal pulmonary embolization was evaluated by examining the 6,385 death certificates filed for a single month in New York City. A total of 207 certificates (3.2%) listed pulmonary embolization as the major or contributory cause of death. Coding methods reduced this figure to 31, with many of the deaths ascribed to other illnesses. Internal discrepancies in the coded data also suggest that in the absence of autopsy, pulmonary embolus as a cause of death is unrecognized at the clinical level. (<i>JAMA</i>230:1677-1679, 1974)
Letter: Son et lumiere?
Authors: H A Daniels
Journal: BMJ (1973)

seen a young mother decerebrated by inappropriate insulin continuation one can never forget it.May I make a second point concerning medical management?In my part of the world we can very frequently manage over- weight pregnant diabetics with on 800-kcal regimen only, with considerable success, even when initial blood glucose levels have been around 300 mg/100 ml.-I am, etc.,
Volume Dependence of Respiratory Impedance in Infants
Authors: FERENC PETÁK, MARK J. HAYDEN, ZOLTÁN HANTOS, PETER D. SLY
Journal: American Journal of Respiratory and Critical Care Medicine (1997)

We previously studied low-frequency respiratory impedance (Zrs) data at an elevated lung volume to separate airway and tissue mechanical properties in normal infants (Am. J. Respir. Crit. Care Med. 1996; 154:161–166). The aim of the present study was to determine the volume dependence of the airway and tissue mechanics by extending Zrs measurements to lower lung volumes. Zrs spectra between 0.5 and 21 Hz were measured in supine sleeping infants (n = 8; 7 to 26 mo of age) at mean transrespiratory pressures (Ptrmean) of 20, 10, and 0 cm H2O, during periods of apnea induced by inflating the infants' lungs to a pressure of 20 cm H2O through a face mask. At each inflation pressure, a model containing airway resistance (Raw) and inertance (Iaw) and tissue damping (G) and elastance (H) was fitted to Zrs data. At FRC, the values of Raw, Iaw, G, and H were 20.6 ± 4.9 (SD) cm H2O · s/L, 0.037 ± 0.014 cm H2O · s2/L, 39.6 ± 10.3 cm H2O/L, and 147 ± 35 cm H2O/L, respectively. Increase of Ptrmean caused a monotonous decrease in Raw (42 ± 7% of the value at FRC), while Iaw remained constant. The tissue parameters were minimal at a Ptrmean of 10 cm H2O (68 ± 10% and 78 ± 6% in G and H, respectively) and significantly higher at both 0 and 20 cm H2O. Although Zrs measurements can be made in most infants at lung volumes as low as FRC, an inflation pressure of 20 cm H2O provides a higher success rate and is therefore a more suitable condition for general use.
Therapeutic Abortion: Medical and Social Sequels
Authors: ANN B. BARNES
Journal: Annals of Internal Medicine (1971)

A retrospective study of 114 patients ranging in age from 12 to 47 years who had had therapeutic abortions showed few medical complications. The large number of women whose most serious problem was their unwanted pregnancy stated that the abortion was helpful. Social activities, religious attitudes, and occupation were little affected by the abortion. For the small number who had serious psychiatric problems the abortion had little effect on the course of their condition. A marked increase in birth control practice followed therapeutic abortion. Most patients cited the need for wider dissemination of birth control information.
Low-dose Theophylline Reduces Eosinophilic Inflammation but Not Exhaled Nitric Oxide in Mild Asthma
Authors: SAM LIM, KATSUYUKI TOMITA, GAETANO CARRAMORI, ANON JATAKANON, BRIAN OLIVER, ANDREAS KELLER, IAN ADCOCK, KIAN FAN CHUNG, PETER J. BARNES
Journal: American Journal of Respiratory and Critical Care Medicine (2001)

Theophylline is well-established in the management of asthma, and there is some evidence of an antiinflammatory effect in asthma. It is not known whether theophylline affects inflammatory markers such as sputum eosinophils and exhaled nitric oxide (NO) in patients with mild asthma not receiving inhaled steroid therapy. In a double-blind, placebo-controlled, cross-over study of 15 patients with mild asthma, we assessed the effect of low-dose theophylline therapy (250 mg twice per day) on eosinophils in induced sputum, bronchoalveolar lavage (BAL) and airway biopsies at the end of both the treatment and placebo periods. Measurements of exhaled nitric oxide (NO) were made at the end of the active and placebo treatment periods of 5 wk each. Low-dose theophylline (mean serum level, 6.1 mg/L) led to a significant reduction in mean (95% confidence interval [CI]) sputum eosinophils from 11.3% (7.80–14.76%) to 8.0% (5.46–10.44%), BAL eosinophils from 3.4% (2.4–4.4%) to 1.7% (1.1–2.3%) and biopsy eosinophils from 1.83% (0.76–2.89%) to 1.20% (0.27–2.13%) compared with placebo (all p < 0.05). There was no significant change in levels of exhaled NO or improvement in lung function and bronchial responsiveness. Low-dose theophylline induced antiinflammatory effects in asthma, reflected by a fall in airway eosinophils with no change in exhaled NO or changes in lung function.
Italy introduces anti-fraud measures
Authors: F. Turone
Journal: BMJ (2003)

The Italian government has approved measures for reducing fraud in the country's health service, provoking strong reactions from both the pharmaceutical industry and the medical profession.

The decree means that any doctors working in the health service may be heavily fined if they are found to have acted improperly.

Investigations of these cases are being led by a special task force based in the health ministry. If the behaviour is deemed by the task force to …
142 THE CHEMOKINE RANTES (CCL5) IS AN IMPORTANT MEDIATOR OF FIBROSIS IN MURINE AND HUMAN CHRONIC LIVER INJURY
Authors: M.L. Berres, A. Rueland, M. Moreno Zaldivar, P. Schmitz, D. Scholten, N. Gassler, C. Weber, C. Trautwein, H.E. Wasmuth
Journal: Journal of Hepatology (2008)
Increased Airway Responsiveness and Decreased Alveolar Attachment Points Following <i>In Utero</i>Smoke Exposure in the Guinea Pig
Authors: JOHN ELLIOT, NEIL CARROLL, MARY BOSCO, MARY McCROHAN, PHIL ROBINSON
Journal: American Journal of Respiratory and Critical Care Medicine (2001)

Maternal smoking during pregnancy has been shown to result in abnormalities in lung function in newborn infants, including reduced expiratory flow and increased airway responsiveness to inhaled agonists. The mechanisms by which this occurs remain unclear. Using a guinea pig model of in utero smoke exposure, we measured airway responsiveness and lung morphology in a group of neonatal guinea pigs 21 d after delivery. Pregnant guinea pigs were exposed to cigarette smoke from Day 28 to term (Day 68 of gestation). After delivery newborn animals did not receive any smoke exposure. Airway wall thickness, smooth muscle area, and the number of points where the alveoli attached to the airway adventitia were measured. Airway responsiveness was increased (p < 0.05) and the mean distance between alveolar attachment points was increased (mean 0.052 ± SE 0.001 mm versus 0.046 ± 0.001, p = 0.001) in animals exposed to cigarette smoke in utero compared with nonexposed animals. Although not statistically significant, both the inner and outer airway wall and the smooth muscle area were greater in exposed animals compared with nonexposed animals. The increased mean distance between alveolar attachments in the smoke-exposed group was the result of a reduction in the number of attachments and an increase in the outer airway wall perimeter. These findings suggest that the increased airway responsiveness observed in postnatal animals, subsequent to in utero cigarette smoke exposure, may be the result of decreased alveolar attachment points to the airways and changes in airway dimensions.
The doctor and the biographer
Authors: C Douglas
Journal: BMJ (1994)

Three of us happened to be standing together in the lounge bar before dinner: a senior colleague, the visitor from London, and me. In the absence of much common ground, talk was slow. It would be an exaggeration to say that at a particular moment a fourth and ghostly presence joined us, but it did feel a bit like that. The evening picked up a lot.

The ghost - who might have been greatly intrigued by what shortly took place - was that of George Orwell. I had read a good deal by and about him, including a recently published and well reviewed biography: written, as it happened, by our visitor from London. And over the years my senior colleague had talked occasionally of Orwell, having looked after him long …
Treatment of Complete Transposition of the Great Vessels with the Blalock-Hanlon Operation
Authors: JOHN L. OCHSNER, DENTON A. COOLEY, LEONARD C. HARRIS, DAN G. MCNAMARA
Journal: Circulation (1961)

Transposition of the great vessels is the most frequent cause of death from congenital heart disease in childhood. The high incidence and poor prognosis of this condition have stimulated the development of many palliative and corrective surgical procedures, but in general their results have been discouraging. During the past 6 years at the Texas Children's Hospital 45 patients with transposition of the great vessels have undergone palliative operation by the creation of an atrial septal defect, using the Blalock-Hanlon technic. The prime criterion for the selection of a patient for surgical treatment was severe anoxemia with or without associated congestive heart failure. The majority of cases were under 1 year of age and 49 per cent less than 3 months of age at the time of surgery. Among 28 patients operated upon during the past 2 years 23, or 82 per cent, survived operation with general improvement. Use of this palliative operation is recommended for the small infant or critically ill patient, and totally corrective procedures should be reserved until conditions are more favorable for survival.
ADMINISTRATION OF HEMATOPOIETIC PROGENITOR CELLS IMPROVED LIMB PERFUSION AND NEOVASCULOGENESIS VIA BY UPREGULATION OF THE ANG–2/TIE–2 PATHWAY
Authors: Georgia Vogiatzi, Dimitris Tousoulis, Alexandros Briasoulis, Aggeliki Valatsou, Anna–Maria Kampoli, Charalambos Antoniades, Christina Chrysochoou, Kostas Toutouzas, Costas Tentolouris, Despoina Perrea, Christodoulos Stefanadis
Journal: Journal of the American College of Cardiology (2013)
Modified Soft-Balloon Methods During Ultrasonic Probe Examination for Superficial Esophageal Cancer
Authors: H. Inoue, T. Kawano, K. Takeshita, T. Iwai
Journal: Endoscopy (1998)

In ultrasonic probe studies for early-stage esophageal cancer the original soft-balloon method utilizing a condom had succeeded in obtaining a clear and reproducible picture by keeping deaerated water in a condom; however, the condom, which covered the endoscope lens, eliminated the usual endoscopic sight. Therefore, the authors endeavored to develop a modified method which enables both normal endoscopic observation and ultrasonic probe study with only a single insertion of the endoscope.Thirty-one patients with superficial esophageal cancer were included in this pilot study. As modifications of the soft-balloon technique, two novel methods of 'wrapping' and 'invagination' were developed.These modifications are considered to have solved the above-mentioned problem and enable one to acquire both normal endoscopic photos and ultrasonic probe images during the same insertion of the endoscope.In a pilot study novel modifications improved the method of ultrasonic probe study for superficial esophageal cancer.
THE ABSORPTION, DISTRIBUTION, AND EXCRETION OF STREPTOMYCIN IN MAN 1
Authors: C. W. Buggs, Matthew A. Pilling, Bernice Bronstein, John Winslow Hirshfeld, Lucille Worzniak, Louie J. Key
Journal: Journal of Clinical Investigation (1946)

Streptomycin, an antibiotic first isolated by Schatz, Bugie and Waksman (1) from the culture filtrate of Actinomyces griseus, has been shown to be effective both in vitro and in sivo against many gram-negatie and gram-positive bacteria (1 to 7).There is also some evidence, based on the treatment of experimentally infected guinea pigs, that it may be of benefit in infections caused by Mycobacterium tuberculosis (8,9).Systemic ad- ministration of streptomycin to animals has shown that they can tolerate doses that are well within
DOWREGULATION OF RNA BINDING PROTEIN QKI6 MEDIATES SUSCEPTIBILITY OF MYOCARDIUM TO ISCHEMIA/REPERFUSION INJURY IN A TYPE 2 DIABETES MODEL, LEPTIN-DEFICIENCY MOUSE
Authors: Wangang Guo, Tiannan Jiang, Heng Ma, Qiangsun Zheng, Haiyan Wang, Department of Cardiology, Tangdu Hospital
Journal: Journal of the American College of Cardiology (2014)
Id2 Drives Differentiation and Suppresses Tumor Formation in the Intestinal Epithelium
Authors: Robert G. Russell, Anna Lasorella, Luis E. Dettin, Antonio Iavarone
Journal: Cancer Research (2004)

Oncogenic signals elevate expression of Id2 in multiple tumor types. When deregulated, Id2 inactivates the tumor suppressor proteins retinoblastoma, p107, and p130. Here, we report a novel and unexpected tumor inhibitory function of Id2 in the intestinal epithelium. First, genetic ablation of Id2 in the mouse prevents differentiation and cell cycle arrest of enterocytes at the time of formation of the crypt-villus unit. Later, these developmental abnormalities evolve toward neoplastic transformation with complete penetrance. Id2-null tumors contain severe dysplastic and metaplastic lesions and express aberrant amounts of beta-catenin. Thus, our data are the first to establish a direct requirement of basic helix-loop-helix inhibitors in driving differentiation and define an unexpected role for the retinoblastoma-binding protein Id2 in preventing tumor formation.
Reticuloendothelial Clearance in Cystic Fibrosis and Other Inflammatory Lung Diseases
Authors: Evangelia C. Mantzouranis, Fred S. Rosen, Harvey R. Colten
Journal: New England Journal of Medicine (1988)

To examine the possible pathophysiologic role of circulating immune complexes in patients with cystic fibrosis and other inflammatory lung diseases, we studied the reticuloendothelial clearance of IgG-sensitized autologous erythrocytes in 15 patients with cystic fibrosis, 6 with chronic obstructive lung disease not related to cystic fibrosis, 7 with immunodeficiencies, 5 with systemic lupus erythematosus, 4 who had previously undergone a splenectomy, and 10 normal subjects. Patients with chronic inflammation and recurrent infections (i.e., those with cystic fibrosis, chronic obstructive lung disease, and immunodeficiencies) had significantly faster clearance rates (P less than 0.05, less than 0.01, and less than 0.005, respectively) than normal subjects. In contrast, patients with systemic lupus erythematosus (a classic immune complex-mediated disease) and those who had undergone a splenectomy had delayed clearance. The accelerated reticuloendothelial clearance in patients with chronic inflammatory pulmonary disease associated with cystic fibrosis was similar to that observed in stimulated laboratory animals. The rapid clearance rate may account for the rareness of septicemia in such patients despite chronic, persistent local bacterial infection.
Clinical Nuclear Cardiology: State of the Art and Future Directions
Authors: Thomas F. Heston
Journal: JAMA (2011)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
COAGULABILITY OF THE BLOOD DURING PREGNANCY AND IN THE NEW-BORN
Authors: FREDERICK HOWARD FALLS
Journal: JAMA (1922)

The coagulability of the blood has been studied by a number of physiologists and clinicians in recent years. The reason for this is the great practical importance of hemorrhage as a complication of both medical and surgical conditions. Of the various branches of medicine, none has a more frequent incidence or more serious forms of hemorrhage than obstetrics. The hemorrhages that the obstetrician may be called on to deal with fall naturally into two classes: maternal, and those occurring in the new-born. Every pregnant woman may have antepartum, intrapartum or postpartum hemorrhage. The blood loss varies from the few hundred cubic centimeters that are lost after every delivery to serious bleedings that may cause a fatal termination in a few minutes. The frequency of bleeding sufficiently severe to be termed a pathologic loss of blood is variously estimated by different authors, but it is safe to say that such bleeding
Warning issued over hip implants
Authors: J. Warden
Journal: BMJ (1998)

A widespread recall of patients with hip replacements is under way in Britain, thanks to the high rate of failure of one type of implant. The Medical Devices Agency issued a hazard warning notice to all hospitals, asking them to review patients who had been fitted with a hip replacement implant made by 3M Health Care.

Investigations by the agency show the 3M Capital hip implant to have an unacceptably high failure rate. …
In-vivo estimation of left ventricular mass: A double indicator technique using a single sensing catheter
Authors: D. W. CRAWFORD, R. BARNDT
Journal: Cardiovascular Research (1974)

Journal Article In-vivo estimation of left ventricular mass: A double indicator technique using a single sensing catheter Get access DONALD W. CRAWFORD, DONALD W. CRAWFORD From the Department of Medicine, Cardiology Section, University of Southern California School of Medicine, Los Angeles, California 90033, USA Search for other works by this author on: Oxford Academic PubMed Google Scholar ROBERT BARNDT, JR ROBERT BARNDT, JR From the Department of Medicine, Cardiology Section, University of Southern California School of Medicine, Los Angeles, California 90033, USA Search for other works by this author on: Oxford Academic PubMed Google Scholar Cardiovascular Research, Volume 8, Issue 5, September 1974, Pages 707–711, https://doi.org/10.1093/cvr/8.5.707 Published: 01 September 1974
Community hospitals still face problems, despite extra £750m
Authors: Zosia Kmietowicz
Journal: BMJ (2006)

The government has made an extra £750m (€1.1bn; $1.4bn) available to new and existing community hospitals in England over the next five years in a bid to regenerate diagnostic and outpatient treatment services closer to where people live.

Some of the money will go towards saving some of the local hospitals currently threatened with closure, said the secretary of state for health, Patricia Hewitt.

But campaigning groups such as Community Hospitals Acting Nationally Together (CHANT) have said the extra cash comes too late for many of the 70 community hospitals that are set to close because of financial problems in the NHS. CHANT said that 10 community hospitals closed in the first six months of this year.

The announcement of extra funding for community services follows the white paper published in January …
Human CIA2A-FAM96A and CIA2B-FAM96B Integrate Iron Homeostasis and Maturation of Different Subsets of Cytosolic-Nuclear Iron-Sulfur Proteins
Authors: Oliver Stehling, Judita Mascarenhas, Ajay A. Vashisht, Alex D. Sheftel, Brigitte Niggemeyer, Ralf Rösser, Antonio J. Pierik, James A. Wohlschlegel, Roland Lill
Journal: Cell Metabolism (2013)
The development of pulmonary vascular obstructive disease after successful Mustard operation in early infancy.
Authors: W Berman, V Whitman, W S Pierce, J A Waldhausen
Journal: Circulation (1978)

Pulmonary vascular obstructive disease developed postoperatively in an infant with aortopulmonary transposition and intact ventricular septum who underwent a Mustard operation in 3 months of age. Preoperative catheterization had shown normal pulmonary artery pressures. Four months after surgery, catheterization showed pulmonary artery systolic pressure above the systemic level and a tortuous, attenuated pulmonary vascular tree visualized angiographically. Early corrective surgery may not preclude the development of pulmonary vascular obstructive disease in patients with aortopulmonary transposition.