tbuckley/cabot-search huggingface dataset:
Abstract 2450: A Randomized Controlled Trial of Low Dose Hormone Therapy on Myocardial Ischemia in Postmenopausal Women with No Obstructive Coronary Artery Disease:Results from the NHLBI-sponsored WISE
Authors: C. Bairey Merz, Marian Olson, Candace McClure, James Symons, George Sopko, Sheryl Kelsey, Eileen Handberg-Thurmond, B. Delia Johnson, Rhonda Cooper-DeHoff, Barry Sharaf, Williams Rogers, Carl Pepine
Journal: Circulation (2007)

Background: Compared with men, women have more evidence of myocardial ischemia in the setting of no obstructive coronary artery disease (CAD). While low endogenous estrogen levels are associated with endothelial dysfunction, the role of low dose hormone therapy has not been fully evaluated in women suffering from myocardial ischemia and no obstructive CAD. Objective: This WISE ancillary trial evaluated the effect of low dose hormone therapy in postmenopausal women with myocardial ischemia and no obstructive CAD on: endothelial dysfunction, assessed by brachial artery reactivity, physical functional disability assessed by exercise testing, and quality of life assessed by cardiac symptoms and psychological questionnaires. Methods: Using a multicenter, randomized, placebo-controlled design, seventy-four participants with normal/minimally diseased epicardial coronary arteries (&lt;50% luminal diameter stenosis) who fulfilled the inclusion criteria were planned to be randomized to receive either 1 mg norethindrone/10 mcg ethinyl estradiol (1/10 NA/EE) or placebo for twelve weeks. Baseline and exit brachial artery reactivity (BART), exercise stress testing, WISE psychosocial questionnaires, SF-36, blood lipids and hormone levels were evaluated. Results: Recruitment was closed prematurely due to failure to recruit in the year following publication of the Women’s Health Initiative hormone trial results. Of the 37 women randomized, 35 completed the study. While there was no difference in the frequency of chest pain between groups at the baseline visit, at study exit there was less frequent chest pain in the 1/10 NA/EE group compared to the placebo group (p=0.02). Women taking 1/10 NA/EE also showed a trend to improved BART and exercise tolerance, and had significantly fewer hot flashes/night sweats (p=0.003), less avoidance of intimacy (p=0.05), and borderline differences in sexual desire and vaginal dryness (p=0.06). Conclusion: Among postmenopausal women with myocardial ischemia and no obstructive CAD, hormone therapy with 1/10 NA/EE is associated with reduced chest pain symptoms, menopausal symptoms and improved quality of life with trends for improved endothelial function and exercise performance.
Acute otitis media
Authors: M. Lindbaek
Journal: BMJ (2000)

Editor—O'Neill's review of the management of acute otitis media from Clinical Evidence was interesting.1 Straand et al showed that 64% of children aged 0-12 years with acute otitis media in a Norwegian county received antibiotic treatment,2 but in a study from an accident and emergency department in Tromso 91% of the children with acute otitis media received antibiotics.3 This shows the conflict between day to day practice and clinical guidelines that recommend no standard antibiotic treatment for acute otitis media.

O'Neill also addresses the question whether children with recurrent otitis media benefit from antibiotic treatment. The latest Norwegian consensus recommends identifying children who should have antibiotic treatment every time they have otitis media.4 These children have had three or more episodes of acute otitis media during the previous six months or four or more episodes during the previous year. Before the age of 2 years 40% of all children will have an episode of acute otitis media, and 4% will have recurrent episodes. Several studies have been performed to explain why these children are prone to ear infections. Risk factors include a genetic disposition, the age of the first ear infection, and male sex.4 Concentrations of antibody against pneumococcus capsule antigens 6A, 14, and 19F are low, and children with recurrent infections are hypothesised to have delayed production of specific immunoglobulins, being unable to increase their own production until the age of 6.4

These factors are reasons for giving children with recurrent episodes antibiotic prophylaxis as an alternative to surgical treatment. In a meta-analysis of 958 children one in nine showed improvement after antibiotic treatment.1 In a small Swedish study intermittent antibiotic treatment with penicillin V for 10 days was given every time the child had an upper respiratory infection.5 This resulted in a 50% reduction in acute otitis media in the group that received antibiotic prophylaxis.

This shows why finding children with recurrent episodes of acute otitis media is an important issue in general practice. Studies are needed to identify how substantial the benefit from antibiotics is in this particular group. The most important issue, however, is to reduce the overuse of antibiotics in the children who will not have recurrent episodes and will therefore recover just as well without antibiotics.
UM171 Is a Novel and Potent Agonist Of Human Hematopoietic Stem Cell Renewal
Authors: Iman Fares, Jalila Chagraoui, Yves Gareau, Stephane Gingras, Ruel Rjean, Elizabeth Csaszar, Sandra Cohen, Marinier Anne, Peter W. Zandstra, Guy Sauvageau
Journal: Blood (2013)
HDAC6 is a specific deacetylase of peroxiredoxins and is involved in redox regulation
Authors: Raphael Parmigiani, Weisheng Xu, Gisela Venta-Perez, Hediye Erdjument-Bromage, Mariana Yaneva, Paul Tempst, Paul Marks
Journal: Clinical Cancer Research (2008)

A19   Eighteen histone deacetylases (HDAC) are present in humans, categorized into two groups: zinc dependent enzymes (HDAC1-11) and NAD+ dependent enzymes (Sirtuins 1-7). Among zinc dependent HDACs, HDAC6 is unique. It has a cytoplasmic localization, two catalytic sites, an ubiquitin binding site and selectively deacetylases α-tubulin and HSP90. Here we report the novel discovery that the redox regulatory proteins, peroxiredoxin (Prx) I and Prx II are specific targets of HDAC6. Prx are antioxidants enzymes whose main function is H2O2 reduction. Prx are elevated in many cancers and neurodegenerative diseases. The acetylated form of Prx accumulates in the absence of an active HDAC6. Acetylation of Prx increases its reducing activity, its resistance to super oxidation and its resistance to transition to high molecular weight complexes. Thus, HDAC6 and Prx are targets for modulating intracellular redox status in therapeutic strategies for disorders as disparate as cancers and neurodegenerative diseases.
B cell–intrinsic deficiency of the Wiskott-Aldrich syndrome protein (WASp) causes severe abnormalities of the peripheral B-cell compartment in mice
Authors: Mike Recher, Siobhan O. Burns, Miguel A. de la Fuente, Stefano Volpi, Carin Dahlberg, Jolan E. Walter, Kristin Moffitt, Divij Mathew, Nadine Honke, Philipp A. Lang, Laura Patrizi, Hervé Falet, Marton Keszei, Masayuki Mizui, Eva Csizmadia, Fabio Candotti, Kari Nadeau, Gerben Bouma, Ottavia M. Delmonte, Francesco Frugoni, Angela B. Ferraz Fomin, David Buchbinder, Emma Maria Lundequist, Michel J. Massaad, George C. Tsokos, John Hartwig, John Manis, Cox Terhorst, Raif S. Geha, Scott Snapper, Karl S. Lang, Richard Malley, Lisa Westerberg, Adrian J. Thrasher, Luigi D. Notarangelo
Journal: Blood (2012)
Rozase hastalarının derisinde oksidatif stres ve ferritin ekspresyonu
Authors: Vesna Sredoja Tisma MD-MSc, Aleksandra Basta Juzbasic, Morana Jaganjac, Luka Brcic, Ivan Dobric, Jasna Lipozencic, Franz Tatzber, Neven Zarkovic, Marija Poljak-Blazi
Journal: Journal of the American Academy of Dermatology (2009)
Abstract 2741: Paradoxical Reduction in Pulse Wave Reflection Following Maximal Exercise in Patients with Type 2 Diabetes Mellitus: Association with Exercise Central Blood Pressure
Authors: Julian W Sacre, David Holland, James E Sharman
Journal: Circulation (2007)

Background: Patients with type 2 diabetes mellitus (T2DM) have increased large artery stiffness and exaggerated brachial and central systolic blood pressure (SBP) responses to exercise. Elevations in exercise central SBP may be a result of increased arterial wave reflections and this study aimed to test this hypothesis. Methods: Maximal exercise stress tests were conducted in 50 T2DM patients (55 ± 8y, 70% males) and 50 controls (56 ± 8y, 70% males) matched by age, gender, maximal exercise brachial SBP and heart rate. Brachial and central BP were measured at rest and immediately post-exercise. Augmentation index (AIx), augmented pressure (AP; markers of wave reflection) and central SBP were recorded by radial tonometry. Results: Despite no significant differences between groups in maximal exercise brachial or central SBP, AIx and AP were significantly lower in T2DM patients (Table ). Exercise central SBP was inversely and independently associated with exercise AIx in the T2DM patients (β= -0.32; p=0.05) but not controls (β= -0.10; p=0.49). The presence of T2DM was also identified as a weak but significant independent determinant of exercise AIx (β= -0.19) and central SBP (β= 0.10; p&lt;0.05 both). Conclusions: Patients with T2DM have 1) a paradoxical reduction in wave reflection at maximal exercise and 2) a significant inverse association between wave reflection and exercise central SBP that is not observed in controls. The reduced reflected pressure waves may indicate an increase in peripheral vasodilation to offset high exercise central BP. Exercise hemodynamics in T2DM patients and controls
HRVC is the commonest rhinovirus group detected in children admitted to a paediatric intensive care unit with respiratory illnesses
Authors: Desmond Cox, Khoo Siew-Kim, Zhang Guicheng, Lindsay Katie, Geoff Knight, Anthony Keil, Jack Goldblatt, Ingrid Laing, Joelene Bizzintino, Peter Le Souef
Journal: European Respiratory Journal (2012)

Introduction: Respiratory viruses account for a significant proportion of acute admissions to the paediatric intensive care unit (PICU). Acute respiratory illnesses (ARI) represent 10-15% of all admissions to PICU. Recent studies have shown that human rhinovirus (HRV) was the most frequent virus detected in severe cases of ARI admitted to a PICU. There has been no study to date examining the prevalence of HRV groups (including the newly discovered HRVC group) in children admitted to a PICU.  Aim: The aim of this study was to determine the prevalence of different HRV groups in children with respiratory illnesses admitted to a tertiary PICU.  Methods: Nasopharyngeal aspirates (NPA) and clinical information were obtained from children admitted with respiratory illnesses to PICU between March 2009 and July 2011. RNA was extracted from NPA, and reversed transcribed. From cDNA, a 2-step PCR of the HRV 5′NCR was used for HRV detection, and sequencing for typing.  Results: NPA from 229 children admitted to PICU were analysed. HRV was the commonest virus, being present in 93 (40.6%) samples examined, followed by respiratory syncytial virus (RSV) which was identified in 50 (21.8%) samples. Of the 77 NPA available for HRV typing, HRVC was found to be the commonest HRV group detected, representing 42 (54.5%) of the samples identified. HRVA group was found in 32 (41.5%) and HRVB in 3 (4%) of the samples analysed.  Conclusions: This study demonstrated that HRV is the commonest virus identified in children admitted to a tertiary PICU with a respiratory illness. In addition, HRVC was the commonest HRV group detected across all respiratory illnesses.
Medicinal use of cannabis
Authors: Marcus Müllner
Journal: BMJ (2001)

The medicinal use of cannabis (p 1313) seems to bother the internet community. Many sites report on the medicinal use of marijuana, weed, ganja, kif, pot, and other trusting names. These sites are, however, mainly about commercial products such as cannabis vaporisers (so that you don't have to inhale the nasty …
Abstract 2572: CpG oligodeoxynucleotide enhances the efficacy of anticancer monoclonal antibody in an <i>in vivo</i> xenograft model using human endometrial cancer cell
Authors: Kosuke Hiramatsu, Satoshi Serada, Kouji Kobiyama, Akiko Morimoto, Toshihiro Kimura, Kiyoshi Yoshino, Minoru Fujimoto, Ken J. Ishii, Masami Fujita, Tetsuji Naka
Journal: Cancer Research (2014)

Abstract Background: CpG oligodeoxynucleotides (ODN) has been shown to exhibit a potent immunostimulatory activity. Therefore, CpG ODN has been considered to be a promising material for enhancing the therapeutic effect of anticancer monoclonal antibody. We have previously identified bone marrow stromal antigen 2 (BST2) as a therapeutic target of endometrial cancer cells and also demonstrated that an anti-BST2 antibody showed a potent anti-tumor effect by antibody-dependent cell-mediated cytotoxicity (ADCC) and complement-dependent cytotoxicity (CDC) against BST2 positive cells. The aim of this study was to evaluate the synergistic anti-tumor effect by combination of anti-BST-2 antibody and CpG ODN, and to clarify the mechanisms of its anti-tumor effect, using xenograft model of anti-BST2 positive endometrial cancer cells. Material and Method: We implanted 7-8 week-old female SCID mice with 5×106 HEC-88 nu endometrial cancer cells subcutaneously. Mice with tumor were treated by intra-peritoneal injection of an anti-BST2 antibody alone (0 - 200 μg/mouse, twice a week for four weeks), intra-tumoral injection of CpG ODN alone (0 - 30 μg/mouse, twice a week for four weeks) or combination therapy (anti-BST2 antibody and CpG ODN). Anti-tumor effect was evaluated by monitoring the changes of tumor volume and also pathological analysis. In addition, activation of NK cells was evaluated. Results: Intraperitoneal treatment of anti-BST2 antibody showed a significant anti-tumor effect, dose dependently. Similarly, intratumoral injection of CpG ODN showed a significant anti-tumor effect, in a dose dependent manner. Interestingly, the combination therapy was more effective than the single-agent therapy. In addition, the combination therapy also resulted in a high activity of NK cells. Conclusion: We showed that CpG ODN increases the efficacy of anti-tumor effect of anti-BST2 antibody induced ADCC activity via potentiating NK cells mediated cancer cell injury. Combination of CpG ODN and anti-tumor monoclonal antibody is useful cancer therapy. Citation Format: Kosuke Hiramatsu, Satoshi Serada, Kouji Kobiyama, Akiko Morimoto, Toshihiro Kimura, Kiyoshi Yoshino, Minoru Fujimoto, Ken J. Ishii, Masami Fujita, Tetsuji Naka. CpG oligodeoxynucleotide enhances the efficacy of anticancer monoclonal antibody in an in vivo xenograft model using human endometrial cancer cell. [abstract]. In: Proceedings of the 105th Annual Meeting of the American Association for Cancer Research; 2014 Apr 5-9; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2014;74(19 Suppl):Abstract nr 2572. doi:10.1158/1538-7445.AM2014-2572
STILBAMIDINE IN THE TREATMENT OF HISTOPLASMOSIS: TWO CASE REPORTS
Authors: J H SEABURY
Journal: Annals of Internal Medicine (1949)

Case Reports1 September 1949STILBAMIDINE IN THE TREATMENT OF HISTOPLASMOSIS: TWO CASE REPORTSJOHN H. SEABURY, M.D.JOHN H. SEABURY, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-31-3-520 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo date, no definitely effective therapeutic agent has been reported for use in histoplasmosis. Isolated instances of apparent improvement or cure following the use of various drugs and physical agents have been published. The final outcome of these cases is, for the most part, not to be found in the literature. The author believes that when hopeful reports are published, particularly in relation to new drugs, the experience of others with these agents should be reported, even if the results are unfavorable. Otherwise, considerable duplication of negative results must occur.Among the more recent drugs to receive tentatively favorable comment...Bibliography1. PARSONSZARAFONETIS RJCJ: Histoplasmosis in man: Reports of seven cases and a review of 71 cases, Arch. Int. Med., 1945, lxxv, 1-23. CrossrefGoogle Scholar2. SEABURYARTIS JHD: In vitro susceptibility of Histoplasma capsulatum to therapeutic agents, Proc. Soc. Exper. Biol. and Med., 1946, lxi, 15-16. CrossrefGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: New Orleans, Louisiana*Received for publication June 13, 1947.From the Department of Internal Medicine, University of Michigan Medical School.†The stilbamidine used was obtained from Merck & Co., through the courtesy of Dr. D. F. Robertson. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byDie AntimykoticaHistoplasmosisHistoplasmosis: Some Clinical, Epidemiological and Laboratory AspectsMycologyIn Vitro Fungistatic Activity of Stilbamidine, Propamidine, Pentamidine and Diethylstilbestrol1Lichen Myxedematosus (Differentiation from Cutaneous Myxedemas or Mucoid States)HISTOPLASMOSIS, WITH REVIEW OF THE LITERATURE AND REPORT OF A CASE, PROVED BY CULTURE, WITH INVOLVEMENT OF THE UPPER LOBE OF EACH LUNG SIMULATING ACTIVE BILATERAL APICAL PULMONARY TUBERCULOSIS*JAMES MONROE, M.D., F.A.C.P., JOSEPH M. KURUNGTHE USE OF THE AROMATIC DIAMIDINES FOR THE TREATMENT OF SYSTEMIC FUNGAL DISEASE*Die MykosenDie Mykosen 1 September 1949Volume 31, Issue 3Page: 520-523KeywordsDrugsHistoplasmosis ePublished: 1 December 2008 Issue Published: 1 September 1949 PDF downloadLoading ...
Comparison of heparin plus IIb/IIIa inhibition versus bivalirudin with or without IIb/IIIa inhibition in patients with acute coronary syndromes undergoing percutaneous coronary intervention: The ACUITY trial
Authors: GW Stone, HD White, EM Ohman, ME Bertrand, AM Lincoff, BT McLaurin, DA Cox, SJ Pocock, JH Ware, A Colombo, R Mehran, JW Moses
Journal: Circulation (2006)
Missense mutations in the human β fibrinogen gene cause congenital afibrinogenemia by impairing fibrinogen secretion
Authors: Stefano Duga, Rosanna Asselta, Elena Santagostino, Sirous Zeinali, Tatjana Simonic, Massimo Malcovati, Pier Mannuccio Mannucci, Maria Luisa Tenchini
Journal: Blood (2000)
Functional analysis of ROMK gene mutations in antenatal Bartter syndrome
Authors: H.H. Lemmink, L.P.W.J. van den Heuvel, C. Buskens, M. Kansen, A. van der Kemp, L.A.H. Monnens, C.H. van Os, N.V.A.M. Knoers, R.J. Bindels
Journal: Journal of the American Society of Nephrology (1997)
Abstract 88: Gravity-Assisted Head-up Cardiopulmonary Resuscitation Improves Cerebral Blood Flow and Perfusion Pressures in a Porcine Model of Cardiac Arrest
Authors: Guillaume Debaty, Sang Do Shin, Anja Metzger, Hyun Ho Ryu, Taeyun Kim, Jennifer Rees, Scott McKnite, Timothy Matsuura, Michael Lick, Demetris Yannopoulos, Keith G Lurie
Journal: Circulation (2014)

Introduction: Compressing the chest during standard cardiopulmonary resuscitation (CPR) increases arterial and venous pressures simultaneously, thus reducing the possibility of a cerebral perfusion gradient during compressions. We hypothesized that CPR with the head up at 30° performed with an enhanced CPR method using the LUCAS-2 for active compression decompression (L-CPR) and an impedance threshold device (ITD) would improve cerebral perfusion by lowering intracranial pressure (ICP) without impairing hemodynamics. Method: Twelve female pigs (39±0.6 kg) were sedated, intubated, anesthetized with isofluorane, paralyzed with succinylcholine (93.3 μg/kg/min) and placed on a tilt table. After 6 minutes of untreated ventricular fibrillation and 2 minutes of CPR, 6 minutes of L-CPR+ITD at 0° supine were performed, followed by 6 minutes of L-CPR+ITD at 30° head up tilt (HUT) and then by 6 minutes of L-CPR+ITD at 30° head down tilt (HDT). Neutron activated microsphere were used to measure vital organ blood flow...
Abstract 16650: Role of Copper Transport Proteins in VSMC Phenotypic Modulation and Vascular Remodeling
Authors: Tetsuro Kamiya, Archita Das, Sudhahar Varadarajan, Rebecca Clifford, Ronald D Mckinney, Jack Kaplan, Masuko Ushio-Fukai, Tohru Fukai
Journal: Circulation (2014)

Vascular smooth muscle cell (VSMC) phenotypic modulation plays a critical role in vascular repair and vascular remodeling after injury. This involves transition from quiescent contractile (C) to de-differentiated phenotype (S)(C to S) induced by PDGF, followed by re-differentiation to contractile phenotype (S to C). Copper (Cu), an essential micronutrient, is involved in vascular remodeling, and its bioavailability is controlled by Cu transport proteins (importer CTR1 and exporter ATP7A) and Cu chaperone (antioxidant-1, Atox1), which activates Cu enzymes such as amine oxidase, SSAO. However, role of Cu transport proteins in VSMC phenotypic modulation is entirely unknown. Here we show that PDGF stimulation in primary VSMC induced de-differentiation (C to S) by downregulating contractile SMC protein, which was accompanied by a robust increase in Cu uptake and CTR1, ATP7A and SSAO levels, and inhibited by Cu chelators. Knockdown of CTR1, ATP7A, SSAO, but not siAtox1, suppressed PDGF-induced VSMC de-differentiation (69%, 72% and 92%, respectively). Of note, ATP7A depletion inhibited PDGF-induced SSAO while SSAO siRNA suppressed ATP7A induction, suggesting that there is a positive feedback loop whereby ATP7A-SSAO pathway promotes de-differentiation. Mechanistically, PDGF-induced expression of KLF4, a repressor of SMC protein expression, was blocked by depletion of CTR1, ATP7A and SSAO. We reported that Atox1 also functions as a Cu-dependent transcription factor independent of ATP7A. Consistently, Atox1 siRNA suppressed serum starvation-induced VSMC re-differentiation, and overexpression of Atox1 increased SMC contractile gene expression. In vivo vascular injury model showed that SSAO and Atox1 were increased in neointimal SMCs at early de-differentiation phase and at later re-differentiation phase, respectively, in response to injury. Summary and Conclusion: CTR1-ATP7A-SSAO pathway is involved in PDGF-induced VSMC de-differentiation via regulating KLF4 while Cu dependent transcription factor function of Atox1 promotes VSMC re-differentiation via regulating SMC contractile gene transcription. Cu transport proteins and SSAO are potential therapeutic targets for modulating VSMC phenotype switching and vascular remodeling.