tbuckley/cabot-search huggingface dataset:
Radiation dose from depleted uranium can now be measured
Authors: Richard F Mould
Journal: BMJ (2001)

EDITOR—In her editorial about depleted uranium McDiarmid agrees that there is no justification for any claims of radiation induced lung cancer and leukaemia in veterans of the Gulf war.1 She makes no mention, however, of how individual radiation doses can be measured in any screening of Gulf war and Balkan veterans.

This is important not only for veterans' peace of mind but also for medicolegal purposes. For due process of law in the courts of the …
Abstract 16905: Fluorescence Resonance Energy Transfer Reveals that Cardiac Calcium ATPase Dimerizes and Forms a Complex with Phospholamban in a 2:1 Stoichiometry
Authors: Daniel Blackwell, Seth L Robia
Journal: Circulation (2014)

The sarco/endoplasmic reticulum calcium ATPase (SERCA) has been proposed to form functional dimers in vitro. In order to investigate whether SERCA forms homo-dimers in live cells, we fused canine SERCA2a to cerulean (Cer) or yellow fluorescent protein (YFP), and quantified SERCA-SERCA interactions by fluorescence resonance energy transfer (FRET). SERCA-SERCA FRET efficiency was dependent on the labeling position of the fluorescent protein tags, with the highest FRET efficiency achieved when the respective fluorescent proteins were fused to SERCA N-termini. FRET was reduced by competition with unlabeled SERCA, suggesting that the observed FRET was due to specific protein-protein interactions. Progressive photobleaching of YFP showed that Cer intensity increased linearly with decreasing YFP intensity, suggesting that the stoichiometry of the SERCA complex is a dimer. In contrast, a control experiment with phospholamban (PLB) oligomer showed a non-linear YFP/Cer relationship, consistent with its well-known pentameric stoichiometry. We also investigated whether SERCA dimers could interact with PLB, the regulatory binding partner of SERCA. Interestingly, while average maximal FRET was 28% between SERCA and PLB, fluorescence lifetime measurements revealed two different lifetimes, consistent with two different populations of FRET donors. One population showed very low FRET, while the other population exhibited high FRET- approximately double the measured average maximal FRET efficiency. The data are consistent with a single PLB bound to each SERCA homo-dimer; in this regulatory complex one SERCA protomer is in close proximity to PLB (50 Å), while the other is too far away to participate in FRET with PLB.
CDC Unveils First Report on Toxins in People
Authors: B Vastag
Journal: JAMA (2001)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Journals JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
NALP3 inflammasome upregulation and CASP1 cleavage of the glucocorticoid receptor cause glucocorticoid resistance in leukemia cells
Authors: Steven W Paugh, Erik J Bonten, Daniel Savic, Laura B Ramsey, William E Thierfelder, Prajwal Gurung, R K Subbarao Malireddi, Marcelo Actis, Anand Mayasundari, Jaeki Min, David R Coss, Lucas T Laudermilk, John C Panetta, J Robert McCorkle, Yiping Fan, Kristine R Crews, Gabriele Stocco, Mark R Wilkinson, Antonio M Ferreira, Cheng Cheng, Wenjian Yang, Seth E Karol, Christian A Fernandez, Barthelemy Diouf, Colton Smith, J Kevin Hicks, Alessandra Zanut, Audrey Giordanengo, Daniel Crona, Joy J Bianchi, Linda Holmfeldt, Charles G Mullighan, Monique L den Boer, Rob Pieters, Sima Jeha, Thomas L Dunwell, Farida Latif, Deepa Bhojwani, William L Carroll, Ching-Hon Pui, Richard M Myers, R Kiplin Guy, Thirumala-Devi Kanneganti, Mary V Relling, William E Evans
Journal: Nature Genetics (2015)
Abstract 2531: Less Invasive but More Effective Method to Prevent Methicillin-Resistant Staphylococcus Aureus (MRSA) Graft Infection by Using Local Sustained Release of Vancomycin (VCM)
Authors: Sakaguchi Hisashi, Keiichi Hirose, Akira Marui, Takamasa Nomura, Yoshio Arai, Yuhong Huang, Shyamal C Bir, Jiro Esaki, Yasuhiko Tabata, Tadashi Ikeda, Masashi Komeda
Journal: Circulation (2006)

Introduction   : MRSA graft infection is one of the most serious complications after vascular surgery because its mortality rate is exceedingly high. VCM is a potent antibiotic to MRSA; however, systemic and repeated administration of VCM is not so effective in MRSA graft infection because the tissue concentration of VCM around the graft may be quite low, and often causes serious side effect. To maintain effective tissue concentration of VCM around the prosthetic graft is thus highly desirable to prevent MRSA graft infection.    Hypothesis  : A local sustained-release of VCM is effective to prevent murine abdominal aortic graft infection model with MRSA without elevation of blood VCM concentration.    Methods   : We have developed poly-L-lactide-co-caprolactone (PLCA) sheet that enabled sustained release of VCM for 2 weeks. Abdominal aorta of a rat was incised and an e-PTFE vascular graft patch (1.5 mm 2 ) was sutured at the anterior wall of the incised aorta. MRSA (1.0±10 3  colony forming units; CFU) was inoculated onto the graft surface. Thereafter, the graft was treated as follows (n=6 each): no treatment (Control group), an aqueous solution of VCM (5mg, VCM/solution group), PLCA-containing VCM (5mg, VCM/PLCA group). Seven days after the operation, the graft and arterial blood were sampled and cultured to count MRSA cells.    Results   : (table) The MRSA count in the graft of VCM/PLCA group were significantly lower than those of the other groups. Blood cultures of VCM/PLCA group were all negative, whereas those of the other groups were all positive. The survival rate in VCM/PLCA group at 28days was higher than Control group.    Conclusion   : A local sustained-release sheet incorporating VCM reduced MRSA in the infected vascular graft, prevented sepsis, and drastically improved survival without elevating blood VCM level. This method may develop more effective but less invasive adjuvant for prevention of prosthetic MRSA graft infection.
Fractures and Dislocations
Authors: [edited by] Ramon B. Gustilo, Richard F. Kyle, David C. Templeman
Journal: BMJ (1943)

Part 1: general principles of fracture treatment historical review of the treatment of fractures and dislocations biomechanics of fracture fixation devices fracture healing tendon and ligament repair in fractures and dislocations the radiographic imaging of fractures use of inductive implants for treating fractures management of the multiple trauma patient open fractures use of the ilazarov external fixator for fractures nonunions, and malunions pathologic fractures and metastatic bone disease. Part 2: the upper extremity - fractures and dislocation of the clavicle, scapula, acromioclavicular joint, and SE head and neck subluxation and dislocations about the shoulder fractures of the humeral shaft fractures and dislocations of the elbow fractures of the shafts of the radius and ulna fractures and dislocations of the wrist fractures and dislocations in the hand. Part III: the spine the cervical spine fractures of the thoracolumbar spine fractures of the sacrum. Part 4: the hip and pelvis fractures of the pelvis fractures of the acetabulum fractures and dislocations of the hip fractures of the femur. Part 5: the lower extremity traumatic dislocation of the knee fractures and dislocations of the patella fractures of the tibia and fibula fractures of the tibial plateau fractures of the distal femur (condylar and supracondylar) fractures and dislocations of the ankle fractures and dislocations of the foot. Part 6: complications of fractures - management of infected fractures infected nonunion compartment syndrome post-traumatic dystrophy gas gangrene.
Expression of the T-Cell–Specific Tyrosine Kinase Lck in Normal B-1 Cells and in Chronic Lymphocytic Leukemia B Cells
Authors: M. Bernardetta Majolini, Mario M. D'Elios, Piero Galieni, Marianna Boncristiano, Francesco Lauria, Gianfranco Del Prete, John L. Telford, Cosima T. Baldari
Journal: Blood (1998)
Epigenetic regulation of gene expression in cervical cancer cells by the tumor microenvironment.
Authors: Nicholas Denko, Cornelia Schindler, Albert Koong, Keith Laderoute, Christopher Green, Amato Giaccia
Journal: Clinical Cancer Research (2000)

Evidence is accumulating that the adverse tumor microenvironment both modifies the malignant progression of tumor cells and contributes to chemotherapy and radiation resistance. We hypothesized that some of the effects on malignant progression are mediated through the transcriptional regulation of genes responsive to the stresses of the microenvironment, such as low oxygen or low glucose conditions. To determine epigenetic changes in gene expression that were consistent with that hypothesis, we used an in vitro subtractive hybridization method, representational difference analysis, to identify hypoxia-induced cDNAs from cultured human cervical epithelial cells. We identified 12 induced genes: two novel genes (HIG1 and HIG2), three genes known to be hypoxia-inducible (tissue factor, GAPDH, thioredoxin), and seven genes not previously identified as hypoxia-inducible [HNRNP(a1), ribosomal L7, annexin V, lipocortin 2, Ku(70), PRPP synthase, and acetoacetyl-CoA thiolase]. In cultured cells, HIG1 and HIG2 expression is induced by hypoxia and by glucose deprivation, but their expression is not induced by serum deprivation, UV, or ionizing radiation. The putative HIG1 and HIG2 open reading frames are expressed in cells, as confirmed by epitope tagging. In addition, tumor xenografts derived from human cervical cancer cells display increased expression of HIG1 and HIG2 when they are deprived of oxygen. Taken together, these data suggest a coordinated transcriptional response of eukaryotic cells to microenvironmental stresses found in the solid tumor.
Abstract 790: A high-throughput chemical screen identifies synergistic activity between neurotransmitter receptor inhibitors and crizotinib in ALK-mutated neuroblastoma
Authors: Nathan Moore, Srunphut Pukma, Nathanael Gray, Rani George
Journal: Cancer Research (2014)

Abstract Activating mutations in the anaplastic lymphoma receptor tyrosine kinase (ALK) represent important therapeutic targets in neuroblastoma, a common childhood cancer that accounts for 15% of all pediatric oncology deaths. One of the more common mutations, ALKF1174L, is sensitive to the sole FDA-approved ALK inhibitor, crizotinib, only at high doses and mediates acquired resistance to crizotinib in ALK-rearranged cancers. To identify compounds that would synergize with crizotinib to increase cytotoxicity in neuroblastoma cells, we devised a high-throughput small molecule synergy screen using the ALKF1174L-dependent SH-SY5Y cell line to compare cell viability between screen compound alone and screen compound in combination with crizotinib. Compounds ranged from those with clinical approval and known therapeutic indications to those with only predicted bioactivity. Of ∼10,000 compounds screened, the most recurrent hits included adrenergic and dopaminergic neurotransmitter receptor inhibitors. Validation studies with a candidate dopamine receptor D2 antagonist, chlorpromazine, resulted in increased cytotoxicity when combined with crizotinib over that of either single agent alone. These studies support further pre-clinical efforts to explore the therapeutic potential of combining crizotinib with neurotransmitter receptor inhibitors in ALKF1174L-mutated neuroblastoma. Citation Format: Nathan Moore, Srunphut Pukma, Nathanael Gray, Rani George. A high-throughput chemical screen identifies synergistic activity between neurotransmitter receptor inhibitors and crizotinib in ALK-mutated neuroblastoma. [abstract]. In: Proceedings of the 105th Annual Meeting of the American Association for Cancer Research; 2014 Apr 5-9; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2014;74(19 Suppl):Abstract nr 790. doi:10.1158/1538-7445.AM2014-790
Abstract P246: Obstructive Sleep Apnea and Particulate Matter Exposure
Authors: Mary Ann McLaughlin, Rupa L Iyengar, Jessica Janneck, Heather N Beebe, Sarah Sanghavi, Simonette T Sawit, Laura E Crowley, Mark Woodward, Cynara Maceda
Journal: Circulation (2014)

Background: Recent studies have found a high prevalence of obstructive sleep apnea (OSA) among responders of the World Trade Center (WTC) disaster. Exposure to particulate matter (PM) causing upper airway inflammation is considered a significant contributing factor in the pathogenesis of OSA. The Berlin Questionnaire (BQ) is a widely used questionnaire to screen for OSA with published sensitivity up to 86% and specificity of 87% for OSA risk. We aim to investigate whether a relationship exists between OSA risk using the BQ and exposure to PM using the Wisnevsky exposure score. Methodology: We evaluated 808 participants in the WTC-CHEST Program from January 2011 to September 2013. High risk for OSA was identified as 2 or more positive categories in the BQ. The subjects were categorized into four exposure groups: very high, high, intermediate and low (Wisnevsky exposure score). Chi-square and Binary Logistic Regression analyses were performed to determine if there was a significant relationship between OSA risk and PM exposure. Results: High risk for OSA is associated with PM exposure in the study population (p=0.002). Using a binary logistic regression adjusting for gender and age, high risk for OSA was still found to be significantly associated with PM exposure (p = 0.022). Conclusion: Prior investigations have demonstrated a link between PM exposure and pulmonary disease, digestive disorders and PTSD. These results provide strong evidence for the association of PM exposure and OSA. In fact, PM exposure in this cohort of WTC first responders is one of the most significant contributors to increased OSA risk. Assessment of both OSA risk and exposure to PM are important as both have been linked to an increase in cardiovascular risk.
Familial Aggregation of Bell's Palsy
Authors: Triantafyllou Ni, Kararizou E, Gkiatas K
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Evaluation of a new 5'-nuclease real-time PCR assay targeting the Toxoplasma gondii AF146527 genomic repeat
Authors: J. Menotti, Y. J-F. Garin, P. Thulliez, M-C. Sérugue, J. Stanislawiak, P. Ribaud, N. de Castro, S. Houzé, F. Derouin
Journal: Clinical Microbiology and Infection (2009)
Abstract 2369: The Circulating Levels of Heart-Type Fatty Acid-Binding Protein (H-FABP) and Brain Natriuretic Peptide (BNP) in General Japanese Population: Effects of Age, Sex, and Other Physiologic Characteristics
Authors: Takeshi Niizeki, Yasuchika Takeishi, Tsuneo Konta, Isao Kubota
Journal: Circulation (2006)

Background: For the precise assessment of reference values, it is important to know biological variations. Although it has been reported that H-FABP, a new marker for myocardial cell injury, and BN...
High concordance of genomic and cytogenetic aberrations between peripheral blood and bone marrow in myelodysplastic syndrome (MDS)
Authors: A M Mohamedali, J Gäken, M Ahmed, F Malik, A E Smith, S Best, S Mian, T Gaymes, R Ireland, A G Kulasekararaj, G J Mufti
Journal: Leukemia (2015)
A phrase which should inform my practice: A positive response from the GP
Authors: A. Bush
Journal: BMJ (1999)

My father was in hospital, paraplegic from a cord compression by a secondary from prostate cancer. He would never walk again. He had been looked after brilliantly by people who were without exception fine human beings in each hospital he had attended. But to him, hospitals as institutions were places where he could never feel remotely at ease Indeed, when courting my mother, a physiotherapist, he would never even go inside the hospital where she …
Researchers Report Findings on HIV Drug Resistance, New Infections
Authors: Joan Stephenson
Journal: JAMA (2004)

SAN FRANCISCO—Resistance to drugs used in simplified drug regimens designed to prevent or treat HIV infection is complicating efforts to fight the AIDS epidemic, according to new findings reported here at the 11th Annual Retrovirus Conference. In addition, researchers described other work highlighting the importance of tracking HIV infection in the United States to identify opportunities for focused prevention efforts.
In hospitalized patients, an electronic alert for acute kidney injury did not differ from usual care
Authors: Rey R. Acedillo, Amit X. Garg, Matthew T. James
Journal: Annals of Internal Medicine (2015)

Source Citation Wilson FP, Shashaty M, Testani J, et al. Automated, electronic alerts for acute kidney injury: a single-blind, parallel-group, randomised controlled trial. Lancet. 2015 Feb 25. Epub ahead of print. 25726515
Oncolytic virus therapy of multiple tumors in the brain requires suppression of innate and elicited antiviral responses
Authors: Keiro Ikeda, Tomotsugu Ichikawa, Hiroaki Wakimoto, Jonathan S. Silver, Thomas S. Deisboeck, Dianne Finkelstein, Griffith R. Harsh, David N. Louis, Raymond T. Bartus, Fred H. Hochberg, E. Antonio Chiocca
Journal: Nature Medicine (1999)
Functional Somatic Syndromes
Authors: Ellen Goudsmit
Journal: Annals of Internal Medicine (2000)

Letters15 February 2000Functional Somatic SyndromesEllen Goudsmit, PhDEllen Goudsmit, PhDTeddington, Middlesex TW11 9QX, United Kingdom (Goudsmit)Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-132-4-200002150-00018 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:Having studied the chronic fatigue syndrome for more than 15 years, I am baffled that Barsky and Borus included it in their review of functional somatic syndromes (1).The chronic fatigue syndrome is not a single entity. The existing criteria for the syndrome include a variety of conditions, including postviral fatigue, undiagnosed sleep disorders, “burn-out,” atypical depression, and symptoms due to hormonal and nutritional deficiencies (2-4). Given the heterogeneity of the affected population, there is no reason why there should be a single cause, let alone an identical set of beliefs and behaviors among patients.The authors' ...References1. Barsky AJ, Borus JF. Functional somatic syndromes. Ann Intern Med. 1999;130:910-21. LinkGoogle Scholar2. Hock AD. Fatigue and 25-hydroxyvitamin D levels. J Chronic Fatigue Syndrome. 1997;3:117-27. CrossrefGoogle Scholar3. Manu P, Lane TJ, Matthews DA, Castriotta RJ, Watson RK, Abeles M. Alpha-delta sleep in patients with a chief complaint of chronic fatigue. South Med J. 1994;87:465-70. CrossrefMedlineGoogle Scholar4. Lerner AM, Zervos M, Dworkin HJ, Chang C, Fitzgerald JT, Goldstein J, et al . New cardiomyopathy: pilot study of intravenous ganciclovir in a subset of the chronic fatigue syndrome. Infect Dis Clin Pract. 1997;6:110-7. CrossrefGoogle Scholar5. Jason LA, Richman JA, Friedberg F, Wagner L, Taylor R, Jordan KM. Politics, science, and the emergence of a new disease. The case of chronic fatigue syndrome. Am Psychol. 1997;52:973-83. CrossrefMedlineGoogle Scholar Author, Article, and Disclosure InformationAffiliations: Teddington, Middlesex TW11 9QX, United Kingdom (Goudsmit) PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoFunctional Somatic Syndromes Arthur J. Barsky and Jonathan F. Borus Functional Somatic Syndromes Melody Heard Functional Somatic Syndromes Frank Albrecht Functional Somatic Syndromes Thomas L. English Functional Somatic Syndromes Thomas L. Kurt Functional Somatic Syndromes Arthur J. Barsky and Jonathan F. Borus Functional Somatic Syndromes Terry E. Hedrick Functional Somatic Syndromes James McSherry Functional Somatic Syndromes Kenneth Clemenger Functional Somatic Syndromes Allan Clemenger Metrics 15 February 2000Volume 132, Issue 4Page: 328KeywordsBehaviorBlindnessChronic fatigue syndromeDepressionEvidence based medicineFatigueMalnutritionPeer reviewPsychologySleep disorders ePublished: 15 August 2000 Issue Published: 15 February 2000 Copyright & PermissionsCopyright © 2000 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Cloning of the human platelet F11 receptor: a cell adhesion molecule member of the immunoglobulin superfamily involved in platelet aggregation
Authors: Malgorzata B. Sobocka, Tomasz Sobocki, Probal Banerjee, Cipora Weiss, Julie I. Rushbrook, Allen J. Norin, John Hartwig, Moro O. Salifu, Mariana S. Markell, Anna Babinska, Yigal H. Ehrlich, Elizabeth Kornecki
Journal: Blood (2000)