Pharmacologic Interventions for Knee Osteoarthritis
Authors: Raveendhara R. Bannuru, David M. Kent, Timothy E. McAlindon
Journal: Annals of Internal Medicine (2015)

Letters5 May 2015Pharmacologic Interventions for Knee OsteoarthritisRaveendhara R. Bannuru, MD, David M. Kent, MD, and Timothy E. McAlindon, MDRaveendhara R. Bannuru, MDFrom Center for Treatment Comparison and Integrative Analysis, Tufts Medical Center, and Institute for Clinical Research and Health Policy Studies, Tufts Medical Center, Boston, Massachusetts.Search for more papers by this author, David M. Kent, MDFrom Center for Treatment Comparison and Integrative Analysis, Tufts Medical Center, and Institute for Clinical Research and Health Policy Studies, Tufts Medical Center, Boston, Massachusetts.Search for more papers by this author, and Timothy E. McAlindon, MDFrom Center for Treatment Comparison and Integrative Analysis, Tufts Medical Center, and Institute for Clinical Research and Health Policy Studies, Tufts Medical Center, Boston, Massachusetts.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/L15-5090-2 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail IN RESPONSE:We wholeheartedly agree that all articles should be faithfully reported and not spun to meet marketing agendas. We concur that comparison of IA hyaluronic acid with IA placebo is scientifically valuable but also maintain that comparison with oral placebo is valuable as well. Both comparisons give valid estimates of treatment effect—but with different meanings. The former measures an explanatory treatment effect that might better indicate the incremental effect due to the biological activity of hyaluronic acid over and above a (potentially) pharmacodynamically inactive saline injection. However, the latter gives a more pragmatic measure that is likely to better ...References1. Bannuru RR, Schmid CH, Kent DM, Vaysbrot EE, Wong JB, McAlindon TE. Comparative effectiveness of pharmacologic interventions for knee osteoarthritis: a systematic review and network meta-analysis. Ann Intern Med. 2015;162:46-54. [PMID: 25560713] doi:10.7326/M14-1231 LinkGoogle Scholar2. Brown GA. AAOS clinical practice guideline: treatment of osteoarthritis of the knee: evidence-based guideline, 2nd edition. J Am Acad Orthop Surg. 2013;21:577-9. [PMID: 23996989] doi:10.5435/JAAOS-21-09-577 CrossrefMedlineGoogle Scholar3. Hochberg MC, Altman RD, April KT, Benkhalti M, Guyatt G, McGowan J, et al; American College of Rheumatology.. American College of Rheumatology 2012 recommendations for the use of nonpharmacologic and pharmacologic therapies in osteoarthritis of the hand, hip, and knee. Arthritis Care Res (Hoboken). 2012;64:465-74. [PMID: 22563589] CrossrefMedlineGoogle Scholar4. McAlindon TE, Bannuru RR, Sullivan MC, Arden NK, Berenbaum F, Bierma-Zeinstra SM, et al. OARSI guidelines for the non-surgical management of knee osteoarthritis. Osteoarthritis Cartilage. 2014;22:363-88. [PMID: 24462672] doi:10.1016/j.joca.2014.01.003 CrossrefMedlineGoogle Scholar Author, Article, and Disclosure InformationAuthors: Raveendhara R. Bannuru, MD; David M. Kent, MD; Timothy E. McAlindon, MDAffiliations: From Center for Treatment Comparison and Integrative Analysis, Tufts Medical Center, and Institute for Clinical Research and Health Policy Studies, Tufts Medical Center, Boston, Massachusetts.Disclosures: Disclosures can be viewed at www.acponline.org/authors/icmje/ConflictOfInterestForms.do?msNum=M14-1231. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoComparative Effectiveness of Pharmacologic Interventions for Knee Osteoarthritis Raveendhara R. Bannuru , Christopher H. Schmid , David M. Kent , Elizaveta E. Vaysbrot , John B. Wong , and Timothy E. McAlindon Comparative Effectiveness of Pharmacologic Interventions for Knee Osteoarthritis Raveendhara R. Bannuru , Christopher H. Schmid , David M. Kent , Elizaveta E. Vaysbrot , John B. Wong , and Timothy E. McAlindon Pharmacologic Interventions for Knee Osteoarthritis Donald M. Marcus Pharmacologic Interventions for Knee Osteoarthritis Donald M. 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