tbuckley/cabot-search huggingface dataset:
Rules over civil servants leaving for jobs in private sector need to be strengthened, says Labour
Authors: G. Iacobucci
Journal: BMJ (2012)

Labour has urged the government to re-examine the rules governing transfer of senior civil servants to the private sector, amid concerns about a possible increase in the number of key figures from the Department of Health going to companies benefiting from government policies.

It comes after the news that Jim Easton, the head of the department’s quality, innovation, productivity, and prevention (QIPP) efficiency programme, is to depart to become managing director of Care UK.

Easton had served as the department’s national director for improvement and efficiency since 2009, holding the post jointly with that as the NHS Commissioning Board’s director of transformation since February 2012.

Questions have been raised about the switch, given Care UK’s status as a prominent private provider of NHS services, which was enhanced last week when the company acquired the competitor …
Management of Rheumatoid Arthritis and Its Complications
Authors: Thomas G. Benedek
Journal: JAMA (1978)

The dual purposes of the author are "to provide a framework that may help the physician manage the rheumatoid patient" and to update his highly regarded monograph<i>Local and Systemic Complications of Rheumatoid Arthritis</i>, published in 1968. To achieve these goals within a rather small space, Hollingsworth has sacrificed the presentation of many practical details in favor of ample references to the literature. This approach diminishes the usefulness of this book "to guide residents, fellows and general physicians." Proper management requires accurate diagnosis. For example, while the differential diagnosis of rheumatoid arthritis from other systemic diseases is presented succinctly but clearly, the differentiation of a bursitis from symptoms of an adjacent arthritis is lacking. Instead of finding directions for the simple procedure of injecting the temporomandibular joints, the physician is advised to refer his patient to a dentist. Although corticosteroid preparations for intra-articular administration are available in at least three
Saline-Resistant Hyperkalemia in Addison's Disease
Authors: SUSAN S. BRAITHWAITE
Journal: Annals of Internal Medicine (1979)

Letters and Corrections1 January 1979Saline-Resistant Hyperkalemia in Addison's DiseaseSUSAN S. BRAITHWAITE, M.D., FRANKLIN L. PERKINS, M.D., RALPH G. RYAN, M.D., GERALD M. GAWLIK, M.D.SUSAN S. BRAITHWAITE, M.D.Search for more papers by this author, FRANKLIN L. PERKINS, M.D.Search for more papers by this author, RALPH G. RYAN, M.D.Search for more papers by this author, GERALD M. GAWLIK, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-90-1-133_1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: We have had the opportunity to see an addisonian diabetic patient with saline-resistant hyperkalemia. This presentation should suggest the possibility of hyperglycemia-induced hyperkalemia, an entity described in diabetic persons with (1) and without (2) selective aldosterone deficiency.The patient was a 28-year-old white man who had had diabetes mellitus since age 13. Past history included appendectomy in 1955, and he had craved salt since about 1976. Since March 1976, treatment at other institutions for arterial insufficiency of the lower extremities had included sympathectomy, bilateral arterial bypass operations, left above-the-knee amputation, and right below-the-knee amputation. Stump infection necessitated...References1. GOLDFARBCOXSINGERGOLDBERG SMIM: Acute hyperkalemia induced by hyperglycemia: hormonal mechanisms. Ann Intern Med 84:426-432, 1976 LinkGoogle Scholar2. AMMONMAYNIGHTINGALE RWS: Glucose-induced hyperkalemia with normal aldosterone levels. Studies in a patient with diabetes mellitus. Ann Intern Med 89:349-351, 1978 LinkGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: The Department of Internal Medicine Loyola University Medical Center Maywood, IL 60153 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByT 1 January 1979Volume 90, Issue 1Page: 133-133KeywordsAldosteroneAppendectomyDiabetes mellitusSaltsSympathectomy Issue Published: 1 January 1979 PDF DownloadLoading ...
The 1991 Albert Lasker Public Service Award. From egg to organism. Studies on embryonic pattern formation
Authors: C. Nusslein-Volhard
Journal: JAMA (1991)

IN THE development of higher organisms, complex patterns are formed in eggs that initially have a simple structural organization, not at all resembling the pattern of the differentiated animal. A fundamental problem of biology is to understand how such complexities arise, and in particular, how much of these complex patterns and in what form they are already prestructured in the egg content. More than 15 years ago, when I began performing the genetic analysis of embryonic pattern formation in<i>Drosophila</i>, most investigations that had been done in this area were on organisms that produce large amounts of eggs that develop in a short time and could easily be manipulated experimentally, such as sea urchins and amphibians. The experimental approaches that had been made involved transplantations or manipulations to find out what happens when one alters the content of the egg cell. The drawback to this type of research is that
Scottish trusts miss cataract surgery targets
Authors: A. Boulton
Journal: BMJ (1997)

The NHS in Scotland could save £1.47m ($2.35m) a year if the number of cataract operations performed as day cases increased to 80% of the total number of cataract operations, according to the National Audit Office (NAO).

The target of 80% by 1997 was originally made by the Scottish Home and Health Department in 1992. The department found that not only was day surgery cheaper than inpatient treatment—with no difference in patient outcome—but many patients preferred it, provided that they received “good, full information” before and after their operations.

Five years later, the NAO found that only 1 out of …
Clinical Evaluation of Blood Flow to the Hand
Authors: BORJE EJRUP, BOGUSLAV FISCHER, IRVING S. WRIGHT
Journal: Circulation (1966)

One hundred fifty individuals of different ages without evidence of peripheral vascular impairment (100 normal persons and 50 patients with history of cerebral vascular disease) were examined with the Allen test; the radial and ulnar arteries were examined in both hands. A false-positive test could easily be obtained spontaneously or be provoked by intentional hyperextension of the hand more than 20° beyond the straight position. In the straight position of the hand, the time for appearance of rubor after opening of the hand exceeded 5 seconds in 34% of the normal persons. When a relaxed slight flexion at the wrist joint was used, the flush after opening the hand appeared at an average of 3 seconds for the ulnar artery and 2.75 for the radial artery. In 50 normal individuals examined with optimal technique described, no individual artery required more than 6 seconds for the flush to appear after opening of the hand. The authors recommend that the Allen test be performed with the patient's hand slightly flexed and relaxed.
Prenatal and Childhood Traffic-Related Pollution Exposure and Childhood Cognition in the Project Viva Cohort (Massachusetts, USA)
Authors: Maria H. Harris, Diane R. Gold, Sheryl L. Rifas-Shiman, Steven J. Melly, Antonella Zanobetti, Brent A. Coull, Joel D. Schwartz, Alexandros Gryparis, Itai Kloog, Petros Koutrakis, David C. Bellinger, Roberta F. White, Sharon K. Sagiv, Emily Oken
Journal: Environmental Health Perspectives (2015)

BackgroundInfluences of prenatal and early-life exposures to air pollution on cognition are not well understood.ObjectivesWe examined associations of gestational and childhood exposure to traffic-related pollution with childhood cognition.MethodsWe studied 1,109 mother–child pairs in Project Viva, a prospective birth cohort study in eastern Massachusetts (USA). In mid-childhood (mean age, 8.0 years), we measured verbal and nonverbal intelligence, visual motor abilities, and visual memory. For periods in late pregnancy and childhood, we estimated spatially and temporally resolved black carbon (BC) and fine particulate matter (PM2.5) exposures, residential proximity to major roadways, and near-residence traffic density. We used linear regression models to examine associations of exposures with cognitive assessment scores, adjusted for potential confounders.ResultsCompared with children living ≥ 200 m from a major roadway at birth, those living < 50 m away had lower nonverbal IQ [–7.5 points; 95% confidence interval (CI): –13.1, –1.9], and somewhat lower verbal IQ (–3.8 points; 95% CI: –8.2, 0.6) and visual motor abilities (–5.3 points; 95% CI: –11.0, 0.4). Cross-sectional associations of major roadway proximity and cognition at mid-childhood were weaker. Prenatal and childhood exposure to traffic density and PM2.5 did not appear to be associated with poorer cognitive performance. Third-trimester and childhood BC exposures were associated with lower verbal IQ in minimally adjusted models; but after adjustment for socioeconomic covariates, associations were attenuated or reversed.ConclusionsResidential proximity to major roadways during gestation and early life may affect cognitive development. Influences of pollutants and socioeconomic conditions on cognition may be difficult to disentangle.CitationHarris MH, Gold DR, Rifas-Shiman SL, Melly SJ, Zanobetti A, Coull BA, Schwartz JD, Gryparis A, Kloog I, Koutrakis P, Bellinger DC, White RF, Sagiv SK, Oken E. 2015. Prenatal and childhood traffic-related pollution exposure and childhood cognition in the Project Viva cohort (Massachusetts, USA). Environ Health Perspect 123:1072–1078; http://dx.doi.org/10.1289/ehp.1408803
Calcium plus vitamin D was associated with increased cardiovascular risk in women not taking personal calcium supplements
Authors: Carolyn J. Crandall, Jane A. Cauley
Journal: Annals of Internal Medicine (2011)

Source Citation Bolland MJ, Grey A, Avenell A, Gamble GD, Reid IR. Calcium supplements with or without vitamin D and risk of cardiovascular events: reanalysis of the Women’s Health Initiative limited access dataset and meta-analysis. BMJ. 2011;342:d2040. 21505219
FURTHER NOTE UPON A CASE OF HYSTERICAL MONOPLEGIA FOLLOWING ELECTRIC SHOCK
Authors: P. Stewart
Journal: BMJ (1914)

jA'JU1A At the hospital it was found that there was blood in the patient's motions and also in the urine.Widal's test being negative, lhe was given calcium lactate, gr.x t.d.s., and a provisional diagnosis of Henoch's purpura was made.As tthere was no improvement at thie enid of a week, hiis blood was sent to the Clinical Research Society to be tested against the paratyphaid group. of organismus, The report, dated February ltlh, 1913, was: The serum agglutinates paratyphoid B in 1 in 10, 1 in 25, 1 in 50, partial with 1 in 100, but none with .1 in 200.Negative to paratyphoid A. No reaction is obtained in controls of either organism made with normal serum.
Breast Cancer Care in Old Age: What We Know, Don't Know, and Do
Authors: R. A. Silliman, L. Balducci, J. S. Goodwin, F. F. Holmes, E. A. Leventhal
Journal: JNCI Journal of the National Cancer Institute (1993)

Journal Article Breast Cancer Care in Old Age: What We Know, Don't Know, and Do Get access Rebecca A. Silliman, Rebecca A. Silliman Division of Health Sciences Research, The Health Institute, New England Medical Center HospitalsBoston, Mass. Correspondence to : Rebecca A. Silliman, M.D., Ph.D., The Health Institute, New England Medical Center Hospitals, 750 Washington St., Box 345, Boston, MA 02111. Search for other works by this author on: Oxford Academic PubMed Google Scholar Lodovico Balducci, Lodovico Balducci Department of Internal Medicine, Division of Medical Oncology, James A. Haley Veterans Hospital, University of South Florida College of MedicineTampa Search for other works by this author on: Oxford Academic PubMed Google Scholar James S. Goodwin, James S. Goodwin Geriatrics Division, The University of Texas Medical Branch, Jennie Sealey HospitalGalveston Search for other works by this author on: Oxford Academic PubMed Google Scholar Frederick F. Holmes, Frederick F. Holmes Division of General and Geriatric Medicine, Department of Medicine, School of Medicine, The University of Kansas Medical CenterKansas City Search for other works by this author on: Oxford Academic PubMed Google Scholar Elaine A. Leventhal Elaine A. Leventhal Division of General Internal Medicine, Department of Medicine, Robert Wood Johnson Medical School, University of Medicine and Dentistry of New JerseyNew Brunswick Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 85, Issue 3, 3 February 1993, Pages 190–199, https://doi.org/10.1093/jnci/85.3.190 Published: 03 February 1993 Article history Received: 31 July 1992 Revision received: 16 November 1992 Accepted: 17 December 1992 Published: 03 February 1993
Disruption of TAB1/p38α Interaction Using a Cell-permeable Peptide Limits Myocardial Ischemia/Reperfusion Injury
Authors: Qingyang Wang, Jiannan Feng, Jing Wang, Xueying Zhang, Dalin Zhang, Ting Zhu, Wendie Wang, Xiaoqian Wang, Jianfeng Jin, Junxia Cao, Xinying Li, Hui Peng, Yan Li, Beifen Shen, Jiyan Zhang
Journal: Molecular Therapy (2013)

Targeting the adaptor protein (transforming growth factor-β (TGF-β)-activated protein kinase 1 (TAK1)-binding protein 1) (TAB1)-mediated non-canonical activation of p38α to limit ischemia/reperfusion (I/R) injury after an acute myocardial infarction seems to be attractive since TAB1/p38α interaction occurs specifically in very limited circumstances and possesses unique structural basis. However, so far no TAB1/p38α interaction inhibitor has been reported due to the limited knowledge about the interfaces. In this study, we sought to identify key amino acids essential for the unique mode of interaction with computer-guided molecular simulations and molecular docking. After validation of the predicted three-dimensional (3-D) structure of TAB1/p38α complex, we designed several peptides and evaluated whether they could block TAB1/p38α interaction with selectivity. We found that a cell-permeable peptide worked as a selective TAB1/p38α interaction inhibitor and decreased myocardial I/R injury. To our knowledge, this is the first TAB1/p38α interaction inhibitor. Targeting the adaptor protein (transforming growth factor-β (TGF-β)-activated protein kinase 1 (TAK1)-binding protein 1) (TAB1)-mediated non-canonical activation of p38α to limit ischemia/reperfusion (I/R) injury after an acute myocardial infarction seems to be attractive since TAB1/p38α interaction occurs specifically in very limited circumstances and possesses unique structural basis. However, so far no TAB1/p38α interaction inhibitor has been reported due to the limited knowledge about the interfaces. In this study, we sought to identify key amino acids essential for the unique mode of interaction with computer-guided molecular simulations and molecular docking. After validation of the predicted three-dimensional (3-D) structure of TAB1/p38α complex, we designed several peptides and evaluated whether they could block TAB1/p38α interaction with selectivity. We found that a cell-permeable peptide worked as a selective TAB1/p38α interaction inhibitor and decreased myocardial I/R injury. To our knowledge, this is the first TAB1/p38α interaction inhibitor.
Entecavir treatment reduces hepatic events and deaths in chronic hepatitis B patients With liver cirrhosis
Authors: Grace Lai-Hung Wong, Henry Lik-Yuen Chan, Christy Wing-Hin Mak, Stanley King-Yeung Lee, Zoe Man-Yi Ip, Andrew Ting-Ho Lam, Henry Wing-Hang Iu, Joyce May-Sum Leung, Jennifer Wing-Yan Lai, Angeline Oi-Shan Lo, Hoi-Yun Chan, Vincent Wai-Sun Wong
Journal: Hepatology (2013)

Entecavir is a potent antiviral agent with high genetic barrier to resistance, hence it is currently recommended as first-line antiviral therapy for chronic hepatitis B (CHB). The aim of this study was to investigate the efficacy of entecavir on clinical outcomes and deaths. It was a retrospective-prospective cohort study based on two cohorts of patients. The entecavir cohort included consecutive CHB patients who had received entecavir 0.5 mg/day for at least 12 months. The historical control cohort included untreated patients recruited since 1997 who underwent routine clinical care. The primary outcome was the 5-year cumulative probability of hepatic events, defined as any cirrhotic complications, hepatocellular carcinoma (HCC), and/or liver-related mortality. A total of 1,446 entecavir-treated patients (72% men; age, 51 ± 12 years; follow-up, 36 ± 13 months) and 424 treatment-naïve patients (65% men; age, 41 ± 13 years; follow-up, 114 ± 31 months) were studied. Overall, there was no difference in hepatic events between the entecavir and control cohorts. Among patients with liver cirrhosis (482 entecavir-treated, 69 treatment-naïve), entecavir-treated patients had reduced risks of all clinical outcomes when compared with treatment-naïve patients with cirrhosis after adjusted for model for end-stage liver disease score: hepatic events (hazard ratio [HR], 0.51; 95% confidence interval [CI], 0.34-0.78; P = 0.002), HCC (HR, 0.55; 95% CI, 0.31-0.99; P = 0.049), liver-related mortality (HR, 0.26; 95% CI, 0.13-0.55; P &lt; 0.001), and all-cause mortality (HR, 0.34; 95% CI, 0.18-0.62; P &lt; 0.001). Entecavir-treated patients with cirrhosis who failed to achieve undetectable hepatitis B virus DNA (105/482 [22%]) had comparable risk of hepatic events as the untreated patients. Conclusion: Entecavir therapy reduces the risks of hepatic events, HCC, liver-related and all-cause mortality of CHB patients with liver cirrhosis in 5 years, particularly among those who had maintained viral suppression. (Hepatology 2013;58:1537–1547)
Identification of a Chemical Inhibitor of the Oncogenic Transcription Factor Forkhead Box M1
Authors: Senthil K. Radhakrishnan, Uppoor G. Bhat, Douglas E. Hughes, I-Ching Wang, Robert H. Costa, Andrei L. Gartel
Journal: Cancer Research (2006)

Abstract The oncogenic transcription factor forkhead box M1 (FoxM1) is overexpressed in a number of different carcinomas, whereas its expression is turned off in terminally differentiated cells. For this reason, FoxM1 is an attractive target for therapeutic intervention in cancer treatment. As a first step toward realizing this goal, in this study, using a high-throughput, cell-based assay system, we screened for and isolated the antibiotic thiazole compound Siomycin A as an inhibitor of FoxM1. Interestingly, we observed that Siomycin A was able to down-regulate the transcriptional activity as well as the protein and mRNA abundance of FoxM1. Consequently, we found that the downstream target genes of FoxM1, such as Cdc25B, Survivin, and CENPB, were repressed. Also, we observed that consistent with earlier reports of FoxM1 inhibition, Siomycin A was able to reduce anchorage-independent growth of cells in soft agar. Furthermore, we found that Siomycin A was able to induce apoptosis selectively in transformed but not normal cells of the same origin. Taken together, our data suggest that FoxM1 inhibitor Siomycin A could represent a useful starting point for the development of anticancer therapeutics. (Cancer Res 2006; 66(19): 9731-5)
Reexamining the Physical Examination for Obese Patients
Authors: Ann Willman Silk, Kathleen M. McTigue
Journal: JAMA (2010)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Regeneration of uterine horns in rats by collagen scaffolds loaded with collagen-binding human basic fibroblast growth factor
Authors: Xin’an Li, Haixiang Sun, Nacheng Lin, Xianglin Hou, Jingmei Wang, Bai Zhou, Peizhen Xu, Zhifeng Xiao, Bing Chen, Jianwu Dai, Yali Hu
Journal: Biomaterials (2011)
Delirium From Digitalis Toxicity
Authors: Henry J. L. Marriott
Journal: JAMA (1968)

<h3>To the Editor:—</h3> I have read "Delirium in a Coronary Care Unit" by Drs. Parker and Hodge (<b>201</b>:702, 1967) with interest, but also with disapproval because of an important and potentially dangerous oversight. The relevant facts are: Some of the country's leading coronary caretakers are openly recommending the almost routine digitalization of patients with acute myocardial infarction. Digitalis is a potent and not rare cause of delirium, which may occur in 3% or 4% of patients intoxicated with the drug.<sup>1</sup> Lethargy, which in the Parker and Hodge series was "frequently associated" with the symptoms of disorientation, is another not uncommon manifestation of digitalis toxicity, especially in bedfast patients. The patients reported by Parker and Hodge are, therefore, a group that may well have been receiving digitalis and it is natural to wonder if any of the delirious patients were suffering from overlooked intoxication. They make no
Anti(marijuana) smoking message directed to 'preteenager' audience
Authors: Kimberly Glasbrenner
Journal: JAMA (1984)

The American Lung Association has designed a community and school-based program that seeks  arm preteenagers with the information needed  say no  marijuana.  American Lung Association data suggest that marijuana use by Americans has increased 30-fold in 20 years. Of the possible 20 million marijuana smokers in the United States, association officials estimate, 2.7 million are teenagers.  Also, these officials say, virtually every American child between ages 12 and 14 years is at some point faced with the decision of whether  smoke marijuana. The purpose of this health education campaign—entitled Marijuana: A Second Look—is to reach children before that time, says James A. Swomley, managing director of the association. We want  reach the 9-, 10-, and 11-year-old fourth- and fifth-graders who still respond  parental and teacher guidance, he explains.  The project is sponsored jointly by the association and by the American Council for Drug Education.