tbuckley/cabot-search huggingface dataset:
Roentgen’s Garden
Authors: Doug Hester
Journal: JAMA (2015)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Name Brand Medically Necessary: Do Not Substitute
Authors: Charles Mason, Amy Givler
Journal: JAMA (2004)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
IgE-binding epitopes: a reappraisal
Authors: R. C. Aalberse, R. Crameri
Journal: Allergy (2011)

To cite this article: Aalberse RC, Crameri R. IgE-binding epitopes: a reappraisal. Allergy 2011; 66: 1261–1274. Here, we discuss various questions related to IgE epitopes: What are the technical possibilities and pitfalls, what is currently known, how can we put this information into hypothetical frameworks and the unavoidable question: how useful is this information for patient care or allergenicity prediction? We discuss the information obtained by (i) 3D structures of allergen–antibody complexes; (ii) analysis of allergen analogues; (iii) mimics without obvious structural similarity; (iv) mAbs competing with IgE; (v) repertoire analysis of cloned IgEs, and other developments. Based on limited data, four suggestions are presented in the literature: (i) IgE might be more cross-reactive than IgG; (ii) IgE might be more often directed to immunologically ‘uninviting’ surfaces; (iii) IgE epitopes may tend to cluster and (iv) IgE paratopes might have a higher intrinsic flexibility. While these are not proven facts, they still can generate hypotheses for future research. The hypothesis is put forward that the IgE repertoire of switched B-cells is less influenced by positive selection, because positive selection might not be able to rescue IgE-switched B cells. While this might be of interest for the discussion about mechanisms leading to allergen-sensitization, we need to be modest in answering the ‘clinical relevance’ question. Current evidence indicates the IgE-epitope repertoire is too big to make specific IgE epitopes a realistic target for diagnosis, treatment or allergenicity prediction. In-depth analysis of a few selected IgE epitope-peptides or mimitopes derived from allergen-sequences and from random peptide libraries, respectively, might well prove rewarding in relation to diagnosis and prognosis of allergy, particularly food allergy.
Combination Antisense Treatment for Destructive Exon Skipping of Myostatin and Open Reading Frame Rescue of Dystrophin in Neonatal mdx Mice
Authors: Ngoc B Lu-Nguyen, Susan A Jarmin, Amer F Saleh, Linda Popplewell, Michael J Gait, George Dickson
Journal: Molecular Therapy (2015)

The fatal X-linked Duchenne muscular dystrophy (DMD), characterized by progressive muscle wasting and muscle weakness, is caused by mutations within the DMD gene. The use of antisense oligonucleotides (AOs) modulating pre-mRNA splicing to restore the disrupted dystrophin reading frame, subsequently generating a shortened but functional protein has emerged as a potential strategy in DMD treatment. AO therapy has recently been applied to induce out-of-frame exon skipping of myostatin pre-mRNA, knocking-down expression of myostatin protein, and such an approach is suggested to enhance muscle hypertrophy/hyperplasia and to reduce muscle necrosis. Within this study, we investigated dual exon skipping of dystrophin and myostatin pre-mRNAs using phosphorodiamidate morpholino oligomers conjugated with an arginine-rich peptide (B-PMOs). Intraperitoneal administration of B-PMOs was performed in neonatal mdx males on the day of birth, and at weeks 3 and 6. At week 9, we observed in treated mice (as compared to age-matched, saline-injected controls) normalization of muscle mass, a recovery in dystrophin expression, and a decrease in muscle necrosis, particularly in the diaphragm. Our data provide a proof of concept for antisense therapy combining dystrophin restoration and myostatin inhibition for the treatment of DMD. The fatal X-linked Duchenne muscular dystrophy (DMD), characterized by progressive muscle wasting and muscle weakness, is caused by mutations within the DMD gene. The use of antisense oligonucleotides (AOs) modulating pre-mRNA splicing to restore the disrupted dystrophin reading frame, subsequently generating a shortened but functional protein has emerged as a potential strategy in DMD treatment. AO therapy has recently been applied to induce out-of-frame exon skipping of myostatin pre-mRNA, knocking-down expression of myostatin protein, and such an approach is suggested to enhance muscle hypertrophy/hyperplasia and to reduce muscle necrosis. Within this study, we investigated dual exon skipping of dystrophin and myostatin pre-mRNAs using phosphorodiamidate morpholino oligomers conjugated with an arginine-rich peptide (B-PMOs). Intraperitoneal administration of B-PMOs was performed in neonatal mdx males on the day of birth, and at weeks 3 and 6. At week 9, we observed in treated mice (as compared to age-matched, saline-injected controls) normalization of muscle mass, a recovery in dystrophin expression, and a decrease in muscle necrosis, particularly in the diaphragm. Our data provide a proof of concept for antisense therapy combining dystrophin restoration and myostatin inhibition for the treatment of DMD.
Probable Transmission of Norovirus on an Airplane
Authors: Marc-Alain Widdowson, Roger Glass, Steve Monroe, R. Suzanne Beard, John W. Bateman, Perrianne Lurie, Caroline Johnson
Journal: JAMA (2005)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
A Fifth Allele at the Histocompatibility-2 Locus of the Mouse as Determined by Tumor Transplantation&lt;xref ref-type="fn" rid="fn1"&gt;&lt;sup&gt;2&lt;/sup&gt;&lt;/xref&gt;&lt;xref ref-type="fn" rid="fn2"&gt;&lt;sup&gt;3&lt;/sup&gt;&lt;/xref&gt;
Authors: G D Snell
Journal: JNCI Journal of the National Cancer Institute (1951)

Journal Article A Fifth Allele at the Histocompatibility-2 Locus of the Mouse as Determined by Tumor Transplantation Get access G. D. Snell G. D. Snell Roscoe B. Jackson Memorial Laboratory, Bar Harbor, Maine Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 11, Issue 6, June 1951, Pages 1299–1305, https://doi.org/10.1093/jnci/11.6.1299 Published: 01 June 1951 Article history Received: 23 April 1951 Published: 01 June 1951
INTERMITTENT HYDRARTHROSIS ASSOCIATED WITH UNDULANT FEVER
Authors: John C. Sharpe
Journal: Annals of Internal Medicine (1936)

Case Reports1 April 1936INTERMITTENT HYDRARTHROSIS ASSOCIATED WITH UNDULANT FEVERJOHN C. SHARPE, M.D.JOHN C. SHARPE, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-9-10-1431 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptArthralgia has long been recognized as part of the symptom-complex of undulant fever. However, true arthritic changes associated with the disease have not been emphasized as a predominant feature. We have had the opportunity in the past few years to see several such cases, which form the basis of another paper1 dealing with these rheumatic manifestations.The following case is of sufficient rarity and interest to warrant its individual consideration.CASE REPORTHistory. J. F., 25, white, male, grocery clerk, entered the University Hospital on December 12, 1934, complaining chiefly of pain and swelling of the knees. The family and...Bibliography1. SHARPEGROW JCMH: The rheumatic manifestations of undulant fever. (To be published.) Google Scholar2. CURTISKREDEL GMFE: Undulant fever complicating toxic goiter, Surg. Clin. N. Am., 1932, xii, 1229-1232. Google Scholar3. BAKER BM: Undulant fever presenting clinical syndrome of intermittent hydrarthrosis, Arch. Int. Med., 1929, xliv, 128-141. CrossrefGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Omaha, Nebraska*Received for publication July 19, 1935.From the Department of Medicine, University of Nebraska, College of Medicine, Omaha, Nebr. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byBRUCELLA ARTHRITIS OF THE HIP JOINT: A REVIEW OF THE LITERATURE AND REPORT OF A CASE TREATED WITH TERRAMYCIN*D. E. BERGSAGEL, M.D., R. E. BEAMISH, M.D., F.A.C.P., J. C. WILT, M.D. 1 April 1936Volume 9, Issue 10Page: 1431-1436KeywordsArthralgiaFeversInflammationKneesSplenomegalySweatSynovial fluidTemperatureVaccinesWeight loss ePublished: 1 December 2008 Issue Published: 1 April 1936 PDF downloadLoading ...
India draws up new guidelines for medical research
Authors: Ganapati Mudur
Journal: BMJ (2000)

The Indian government has finalised a set of ethical guidelines for biomedical research in humans, but policymakers say that they will need to be backed by legislation “for real impact.”

The guidelines, released by the Indian Council of Medical Research this week, cover wide ranging issues including informed consent, procedures for new drug trials, fetal research, transplantation, and human genetics.

All institutions engaged in biomedical research have been asked to set up institutional ethics committees to …
Cholesterol lowering diets and coronary heart disease
Authors: D. W Evans, R. Bhopal
Journal: BMJ (1999)

Ductal carcinoma in situ of the breast Has author carried out an audit?Editor-We were interested in Silverstein's review on ductal carcinoma in situ. 1 He states that he performs mammography every 6 months on the ipsilateral breast and every year on the contralateral breast.Has he been able to audit the usefulness of this practice-namely, how many times has the mammogram predated the development of clinical recurrence?
Lesson of the week: Physiological effects of starvation interpreted as food allergy
Authors: C A Bethune, M M Gompels, G P Spickett
Journal: BMJ (1999)

Carbohydrate restriction can disturb glucose metabolism, and this may be interpreted falsely as food allergy

It is a common misconception that food allergy can cause a wide variety of symptoms. A population study in the English town of High Wycombe showed a perceived prevalence of food intolerance of almost 20%, but double blind food challenge (the definitive test) provided objective evidence of symptoms related to food in fewer than 2% of subjects.1 This popular belief is fuelled by extensive and often misleading reports on the subject, as well as the emergence of clinics offering unvalidated tests that claim to diagnose allergy.2

We describe three patients who undertook strict, low carbohydrate diets because of perceived allergy. Starvation may affect the response to an oral glucose challenge. It results in an initial excessive rise in the blood glucose concentration followed by hypoglycaemia, which can be accompanied by symptoms.3 4 All three of the patients described developed symptoms several hours after meals and attributed these to food allergy. Further restriction of carbohydrate intake exacerbated their problem Symptoms continued to occur after meals and were erroneously interpreted as further evidence of their carbohydrate allergy.

### Case 1

A 24 year old woman was referred with a 4 month history of diarrhoea and abdominal pain. A self prescribed wheat free diet had improved her symptoms at first, but as she restricted her diet further she began to complain of dizziness, weakness, nausea, and palpitations, which were most severe several hours after meals. She concluded that she was allergic to many foods, and cut down her intake further. The woman lost 5 kg in weight, and …
Arrhythmia Monitoring Through Pacemakers
Authors: Olivier Piot
Journal: Circulation (2003)

To the Editor:In their ancillary study of the MOde Selection Trial (MOST) study, Glotzer et al 1 provide important findings about the clinical relevance of arrhythmia monitoring through pacemakers in patients with sinus node dysfunction.However, their results do not support those of the MOST study.In the MOST study, 2 the development of clinically evident atrial fibrillation was observed less often in the patients with the DDD mode of pacing, but the pacing mode had no effect on stroke occurrence.In this ancillary study of MOST, the occurrence of nonsustained atrial arrhythmias was not influenced by the pacing mode, and the patients with such arrhythmias had a higher mortality.How does the DDD mode prevent clinically evident atrial fibrillation but not the occurrence of nonsustained atrial arrhythmias?Which kind of arrhythmia is then relevant in terms of prognosis in pacemaker patients-a symptomatic atrial fibrillation or a nonsustained atrial arrhythmia that is often asymptomatic?
Meningococcal Vaccination
Authors: Kristine A. Moore, Michael T. Osterholm
Journal: JAMA (1998)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Abstract P5-04-14: Decreased functions of natural killer cells in peripheral blood of advanced triple negative breast cancer patients
Authors: In Hae Park, Sun-Young Kong, Joo Hyun Kang, Hye Jin Mo, Tae Sik Kim, Keun Seok Lee, Jungsil Ro
Journal: Cancer Research (2015)

Abstract Background : Natural killer (NK) cells are a major player in innate immune response. Two distinct NK cell subsets with different functions as the strongest cytotoxic activity (CD56dimCD16+) or cytokine production (CD56brightCD16+/-) have been known. In this study, we evaluated the phenotypic and functional difference of NK cells in peripheral blood (pB) from the patients who had advanced triple negative (TN) breast cancer compared to healthy controls. Methods : We enrolled advanced triple negative (TN) breast cancer patients treated at the National Cancer Center, Korea between March 2012 and March 2014. Healthy controls who visited for health screening were recruited at the same time period and peripheral blood (pB) samples were collected. In patient groups, pB was sampled either prior to the initiation or during the courses of chemotherapy. Then, patients were retrospectively classified into two groups as follows; non-responders (the group A) and responders (the group B) to the treatment. NK cells were isolated from peripheral blood mononuclear cells (PBMC) and analyzed based on their expression of CD56 and CD16. We looked at cytotoxic activity of pB NK cells against K562 cell line and measured CD107a expression as a parameter of NK cell activation. Results : The absolute numbers of lymphocytes and NK cells per cubic millimeter of pB were similar among healthy controls (N=24), the group A (N=16), and the group B (N=21). There was no significant difference in the proportion of pB NK cell subsets among three groups except CD56brightCD16+/- subset which was significantly higher in the group B compared to healthy controls (P=0.0014). Even in the presence of similar proportions of NK subsets, the activities of CD56dimCD16+ NK cells measured by CD107a expression were significantly lower both in the group A (P=0.0023) and in the group B (P=0.0127) compared with those of control group. The activities of CD56dimCD16+ NK cells were not different between group A and B. In the case of CD56brightCD16+/- NK cells, CD107a positivity was significantly lower in the group A compared with controls (P=0.0068) and group B (P=0.0465). Conclusions : Our data suggested that cytolytic functions of NK cells were significantly decreased in advanced TN breast cancer patients compared with those of healthy controls despite a similar proportion of NK cell subsets in pB. Citation Format: In Hae Park, Sun-Young Kong, Joo Hyun Kang, Hye Jin Mo, Tae Sik Kim, Keun Seok Lee, Jungsil Ro. Decreased functions of natural killer cells in peripheral blood of advanced triple negative breast cancer patients [abstract]. In: Proceedings of the Thirty-Seventh Annual CTRC-AACR San Antonio Breast Cancer Symposium: 2014 Dec 9-13; San Antonio, TX. Philadelphia (PA): AACR; Cancer Res 2015;75(9 Suppl):Abstract nr P5-04-14.
Chemicals Linked to Bladder Cancer in Smokers May Play Wider Role
Authors: Tracy Hampton
Journal: JAMA (2004)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal