CHRONIC LEUKOPENIA WITH FATAL TERMINATION DUE TO AGRANULOCYTIC ANGINA; CASE REPORT
Authors: Israel Kopp
Journal: Annals of Internal Medicine (1940)

Case Reports1 June 1940CHRONIC LEUKOPENIA WITH FATAL TERMINATION DUE TO AGRANULOCYTIC ANGINA; CASE REPORTISRAEL KOPP, M.D.ISRAEL KOPP, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-13-12-2347 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe literature now contains many case reports of agranulocytosis since its first description by Schultz in 1922.1 Various hypotheses as to its etiology have been offered, and a number of drugs, nearly all containing the benzene ring, have been implicated.2, 3, 4Agranulocytosis has been defined as a disease in which essentially there is a marked diminution or total absence of the granulocytes of the peripheral blood, which is followed by a loss of cellular resistance as shown by infectious processes of various types.4Various other descriptive terms have been given to this syndrome, such as agranulocytic angina, primary granulocytopenia...References1. SCHULTZ W: Ueber eigenartige Halserkrankungen (a) Monocyten Angina (b) Gangränezierende Prozesse und Defekt des Granulozytensystems, Deutsch. med. Wchnschr., 1922, xlviii, 1495. Google Scholar2. FITZ-HUGH T: Pernicious leukopenia: clinical and experimental background and present status, Med. Clin. North Am., 1935, xix, 103. Google Scholar3. JACKSONPARKER HF: Agranulocytosis: its etiology and treatment, New England Jr. Med., 1935, ccxii, 137. CrossrefGoogle Scholar4. KRACKEPARKER RRFP: The relationship of drug therapy to agranulocytosis, Jr. Am. Med. Assoc., 1935, cv, 960. CrossrefGoogle Scholar5. RUTLEDGEHANSEN-PRUSSTHAYER BHOCWS: Recurrent agranulocytosis, Bull. Johns Hopkins Hosp., 1930, xlvi, 47. Google Scholar6. EMBLETON D: Rhythmical neutropenia with recurrent buccal ulceration, Proc. Roy. Soc. Med., 1937, xxx, 980. CrossrefGoogle Scholar7. STEALY CL: Chronic granulocytopenia of five years' duration with recurrent acute attacks—case report, Am. Jr. Med. Sci., 1935, clxxxix, 633. CrossrefGoogle Scholar8. STEPHENSLAWRENCE DJJS: Cyclical agranulocytic angina, ANN. INT. MED., 1935, ix, 31. Google Scholar9. JACKSONMERRILL HD: Agranulocytic angina associated with menstrual cycle, New England Jr. Med., 1934, ccx, 175. CrossrefGoogle Scholar10. KRACKE RR: Recurrent agranulocytosis, Am. Jr. Clin. Path., 1931, i, 385. CrossrefGoogle Scholar11. HECK FJ: Recurrent granulocytopenia, Proc. Staff Meet. Mayo Clin., 1934, ix, 200. Google Scholar12. DOAN CA: The neutropenic state, its significance and therapeutic rationale, Jr. Am. Med. Assoc., 1932, xcix, 194. CrossrefGoogle Scholar13. KRACKE RR: Relation of drug therapy to neutropenic states, Jr. Am. Med. Assoc., 1938, cxi, 1255. CrossrefGoogle Scholar14. MINTER MM: In discussion of HARKINS, H.: Granulopenia and agranulocytic angina, Jr. Am. Med. Assoc., 1932, xcix, 1132. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Boston, Massachusetts*Received for publication February 1, 1939.From the Boston Psychopathic Hospital. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byChronic hypoplastic neutropenia 1 June 1940Volume 13, Issue 12Page: 2347-2354KeywordsAnginaBloodDrugsEtiologyGranulocytesInfectious diseases ePublished: 1 December 2008 Issue Published: 1 June 1940 PDF downloadLoading ...