tbuckley/cabot-search huggingface dataset:
Monocrotaline promotes transplanted cell engraftment and advances liver repopulation in rats via liver conditioning
Authors: Brigid Joseph, Vinay Kumaran, Ekaterine Berishvili, Kuldeep K. Bhargava, Christopher J. Palestro, Sanjeev Gupta
Journal: Hepatology (2006)

Disruption of the hepatic endothelial barrier or Kupffer cell function facilitates transplanted cell engraftment in the liver. To determine whether these mechanisms could be activated simultaneously, we studied the effects of monocrotaline, a pyrollizidine alkaloid, with reported toxicity in liver sinusoidal endothelial cells and Kupffer cells. The effects of monocrotaline in Fischer 344 rats were examined by tissue morphology, serum hyaluronic acid levels, and liver tests (endothelial and hepatocyte injury) or incorporation of carbon and (99m)Tc-sulfur colloid (Kupffer cell damage). To study changes in cell engraftment and liver repopulation, Fischer 344 rat hepatocytes were transplanted into syngeneic dipeptidyl peptidase IV-deficient rats followed by histological assays. We observed extensive endothelial injury without Kupffer cell or hepatocyte damage in monocrotaline-treated rats. Monocrotaline enhanced transplanted cell engraftment without changes in transplanted cell numbers or induction of proliferation in native hepatocytes over 3 months. In monocrotaline-treated rats, transplanted cells integrated into the liver parenchyma and survived in vascular spaces. To determine whether native hepatocytes suffered inapparent damage after monocrotaline, we introduced further liver injury with carbon tetrachloride subsequent to cell transplantation. Monocrotaline sensitized the liver to carbon tetrachloride-induced necrosis, which advanced transplanted cell proliferation, leading to significant liver repopulation. During this process, we observed proliferation of bile duct cells and small epithelial cells, although transplanted hepatocytes did not appear to reconstitute bile ducts. The studies showed that perturbation of multiple liver cell compartments by monocrotaline promoted transplanted cell engraftment and proliferation. In conclusion, development of drugs with monocrotaline-like effects will help advance liver cell therapy.
Panic Disorder—It's Real and It's Treatable
Authors: Richard M. Glass
Journal: JAMA (2000)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Shifting the focus in fracture prevention from osteoporosis to falls
Authors: Teppo L N Järvinen, Harri Sievänen, Karim M Khan, Ari Heinonen, Pekka Kannus
Journal: BMJ (2008)

Preventing fractures in older people is important. But <b>Teppo Järvinen and colleagues </b>believe that we should be putting our efforts into stopping falls not treating low bone mineral density
Formal and informal support received by carers of elderly dependents.
Authors: D A Jones, N J Vetter
Journal: BMJ (1985)

This study describes the activity of informal carers who look after elderly dependents and particularly investigates the role of formal services in supporting these carers in maintaining dependent, elderly people in the community. The results lend no support to the view that families neglect their elderly relatives or that community services displace the role of informal carers, but rather suggest that carers support elderly dependents at great cost to themselves and with inadequate support from community services.
Offline: The mid-life obituary
Authors: Richard Horton
Journal: The Lancet (2011)

Word arrives that an editor is soon to leave a medical journal. Did he jump or was he pushed? Pushed, says my informant. The allegation was moonlighting and denying an author the right to criticise the institution the editor was moonlighting for. Authors are not the only people, it seems, who can have career-fatal conflicts of interest.
Hidradenitis suppurativa fulminans: a clinically distinct phenotype?
Authors: B. Moriarty, A. Pink, D. Creamer, N. Desai
Journal: British Journal of Dermatology (2014)

Journal Article Hidradenitis suppurativa fulminans: a clinically distinct phenotype? Get access B. Moriarty, B. Moriarty Department of Dermatology King's College Hospital Denmark Hill London SE5 9RS U.K Search for other works by this author on: Oxford Academic Google Scholar A. Pink, A. Pink St John's Institute of Dermatology Guy's and St Thomas' NHS Foundation Trust London U.K Search for other works by this author on: Oxford Academic Google Scholar D. Creamer, D. Creamer Department of Dermatology King's College Hospital Denmark Hill London SE5 9RS U.K Search for other works by this author on: Oxford Academic Google Scholar N. Desai N. Desai St John's Institute of Dermatology Guy's and St Thomas' NHS Foundation Trust London U.K Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 171, Issue 6, 1 December 2014, Pages 1576–1578, https://doi.org/10.1111/bjd.13147 Published: 01 December 2014
Platypnea-Orthodeoxia Syndrome
Authors: Shohei Yoshida, Sawa Nambu, Takao Matsubara, Toshihiko Yasuda, Kenji Miwa, Masaru Inoue, Ryota Teramoto, Hirofumi Okada, Hounin Kanaya, Makoto Tsubota, Tetsuo Konno, Kenshi Hayashi, Masa-aki Kawashiri, Masakazu Yamagishi
Journal: Journal of the American College of Cardiology (2013)
Deficient expression of NCR in NK cells from acute myeloid leukemia: evolution during leukemia treatment and impact of leukemia cells in NCRdull phenotype induction
Authors: Cyril Fauriat, Sylvaine Just-Landi, Françoise Mallet, Christine Arnoulet, Danielle Sainty, Daniel Olive, Regis T. Costello
Journal: Blood (2006)
Understanding patterns in maternity care in the NHS and getting it right
Authors: L. C. Chappell, C. Calderwood, S. Kenyon, E. S. Draper, M. Knight
Journal: BMJ (2013)

It’s important to choose the right indicators, use high quality data, and engage all stakeholders This week, the Royal College of Obstetricians and Gynaecologists published its report on patterns of maternity care in English NHS hospitals during 2011 to 2012.1 The stated aim was to “examine the validity of potential performance indicators, and to determine how successfully these could be used to compare performance between maternity units using available data.” Data from inpatient admissions and day cases collected routinely from English NHS trusts through Hospital Episode Statistics (HES) were analysed to provide an initial 11 performance indicators, all related to intrapartum care (box). The report presents the data as risk adjusted estimates for each maternity unit within a funnel plot showing the national mean. If variation occurred at random, only one in 20 or one in 500 units would be expected to lie outside the limits representing two (inner funnel limits) or three (outer limits) standard deviations, respectively. #### Indicators chosen for inclusion in the report
Pharmacokinetic Berinert P Study Of Subcutaneous Versus Intravenous Administration In Subjects With Moderate Hereditary Angioedema - The Passion Study
Authors: I. Martinez-Saguer, M. Cicardi, E. Aygören-Pürsün, E. Rusicke, T. Klingebiel, W. Kreuz
Journal: Journal of Allergy and Clinical Immunology (2011)
Gastroenterology trainees' views on educational supervisors: do they fulfil their role?
Authors: D. G. Walker, J. N. Walker, T. R. Orchard
Journal: Gut (2011)

<h3>Introduction</h3> Since January 2010 all educational supervisors in London must be accredited for their role against a set of mandatory requirements developed by the London Deanery. The aim of this study was to first analyse how closely the experience of North London gastroenterology trainees fits with the London Deanery guidelines for what is expected of educational supervisors and second to determine what aspects of educational supervision trainees felt were most important. To date, no studies related to educational supervisors have been performed in the specialty of gastroenterology. <h3>Methods</h3> The study was conducted in two parts. first, gastroenterology trainees from Imperial College London participated in a focus group to help develop a questionnaire which consisted of a 9-item self-report Likert scale with a 5-point response choice (1 = strongly disagree to 5 = strongly agree). Additionally, there was an open-ended question that asked participants to comment on what they felt the most important aspects of educational supervision were. The questionnaire was personally distributed to 61 registrars at a North London gastroenterology training day with a 98% (60/61) completion rate. The Likert scale results were reported as item level frequencies and the responses from the open question were organised into themes for further analysis. <h3>Results</h3> Ninety-eight percent of trainees (59/60) had an educational supervisor. Overall, the results illustrated that trainees felt that their educational supervision fell below the standards expected by the London Deanery. 58% of trainees felt that they do not receive sufficient input into their portfolios. 39% felt they do not receive sufficient feedback on their work-based assessments and 37% reported that they were not set adequate educational objectives. The open question highlighted a number of attributes that trainees felt would make a good educational supervisor. Three out of the top five attributes relate to pastoral care (supportive, available &amp; approachable) which were not part of the mandatory requirements in the London Deanery framework. <h3>Conclusion</h3> It is encouraging that 98% of trainees had been assigned an educational supervisor. However, over a third of trainees felt their supervisor could be more effective in providing input into their e-portfolios, giving feedback on assessments and setting educational objectives. It is very important that educational supervisors are aware of these findings so standards can be improved. The study also suggests that trainees value other aspects of educational supervision that are not captured by the current requirements; Deaneries should examine this further when forming future guidelines.
MODIFIED IMMUNOSUPPRESSION AND NEUROHUMORAL BLOCKADE MAY PREVENT VENTRICULAR REMODELING AND IMPROVE CLINICAL OUTCOME IN PATIENTS WITH CARDIAC SARCOIDOSIS
Authors: Yoshikazu Yazaki, Toshimasa Seki, Yukiko Hayashi, Atsushi Izawa, Minoru Hongo, Uichi Ikeda
Journal: Journal of the American College of Cardiology (2013)
1177 INTERLEUKIN-28B PREDICTS SVR IN LATIN AMERICAN HEPATITIS C GENOTYPE 1 PATIENTS TREATED WITH PEG IFN AND RIBAVIRIN
Authors: E. Ridruejo, A. Solano, D. Delettieres, A. Martínez, S. Marciano, O.G. Mandó, O. Galdame, A. Gadano, M.O. Silva, R. Adrover, D. Cocozzella
Journal: Journal of Hepatology (2011)
Lymphatic Mapping and Sentinel Node Biopsy in Breast Cancer
Authors: Armando E. Giuliano
Journal: JAMA (1997)

<h3>To the Editor.</h3> —The study by Dr Albertini and colleagues<sup>1</sup>confirms our sentinel node hypothesis in breast cancer. Since our group began investigating the sentinel node technique for breast cancer 5 years ago, we have performed nearly 400 mapping procedures using isosulfan blue dye to identify the first axillary lymph node draining a primary breast cancer,<sup>2,3</sup>and have abandoned routine axillary lymph node dissection. As reported in a summary of our last 100 cases, dye-based mapping in our hands has reached an accuracy of 100%, with a 93% rate of sentinel node detection.<sup>4</sup>Thus, the authors' comment, "Previous studies have used either the vital blue dye or the radiocolloid alone, with lower success rates reported," is not correct. In addition, the use of preoperative lymphoscintigraphy for inner-quadrant lesions has increased our detection rate even further. Although we have started to evaluate the combined use of blue dye
Mechanism of mitogen-induced stimulation of glucose transport in human peripheral blood mononuclear cells. Evidence of an intracellular reserve pool of glucose carriers and their recruitment.
Authors: D B Jacobs, T P Lee, C Y Jung, B K Mookerjee
Journal: Journal of Clinical Investigation (1989)

The present study examines the effects of phytohemagglutinin stimulation of a population of human (h) PBMC enriched in lymphocytes (hPBMC) on D-glucose displaceable cytochalasin B binding sites or medium-affinity sites (M-sites) in relation to glucose transport. Previously we have shown that M-sites are glucose transporters in hPBMC (Mookerjee, B.K., et al. 1981. J. Biol. Chem. 256:1290-1300). Equilibrium exchange of 3-O-methyl D-glucose in unstimulated cells revealed two populations with fast and slow flux rates. Phytohemagglutinin stimulates flux rates by converting part of the slow flux population to the fast flux population. M-sites occur in two distinct pools, one in plasma membrane and the other in microsomal fraction. Phytohemagglutinin treatment increases the plasma membrane pool size of M-sites with a concomitant reduction in the microsomal pool size without affecting the binding affinities or the total number of M-sites/cell. Data presented in this paper demonstrate that there are two pools of glucose transporters in these cells and phytohemagglutinin stimulation induces an energy-dependent net translocation of glucose transporters from an intracellular reserve pool to the plasma membrane, which accounts for greater than 60% of the increment in glucose transport.
Safety and efficacy of rituximab in patients with hepatitis C virus–related mixed cryoglobulinemia and severe liver disease
Authors: Antonio Petrarca, Luigi Rigacci, Patrizio Caini, Stefano Colagrande, Paolo Romagnoli, Francesco Vizzutti, Umberto Arena, Carlo Giannini, Monica Monti, Paolo Montalto, Marco Matucci-Cerinic, Alberto Bosi, Giacomo Laffi, Anna Linda Zignego
Journal: Blood (2010)
Campaigners for full smoking ban in Germany flag up workers' rights
Authors: N. Stafford
Journal: BMJ (2010)

Supporters of a complete ban on smoking in Germany’s pubs and restaurants have started a new public relations offensive to convince politicians to enact a uniform national ban similar to the stringent smoke free laws in the United Kingdom and Ireland.

The German Cancer Research Centre kicked off the campaign on 22 June by publishing a new report analysing the effects of non-uniform partial smoking bans enacted over the past three years by Germany’s 16 states.

On the positive side, the report notes that partial bans have improved “air quality in public places” and have increased the proportion …
Measures to Control Chlamydia trachomatis Infections: An Assessment of New National Policy Guidelines
Authors: Walter E. Stamm
Journal: JAMA (1986)

Somewhat hidden perhaps among the barrage of publications on the acquired immunodeficiency syndrome in recent months was a report on policy guidelines for prevention and control of<i>Chlamydia trachomatis</i>infections by the Centers for Disease Control (CDC).<sup>1</sup>This report summarizes the deliberations of an expert committee and of CDC staff members, whose task it was to outline a plan for control of this growing public health problem. The effort was worthwhile—the report provides the most up-to-date and succinct summary of the public health importance of<i>C trachomatis</i>infections that is currently available. It outlines the role played by<i>C trachomatis</i>in various disease syndromes; the numbers and economic impact of these infections; risk factors that can be used to identify high-risk groups or individuals; approaches to the diagnosis and treatment of<i>C trachomatis</i>infections; newer laboratory tests for diagnosis; and potential means of controlling the increasing incidence of these
Male pill could soon be reality
Authors: D. Carnall
Journal: BMJ (1996)

399 fertile men in 16 countries voluntarily received weekly injections of testosterone for up to 18 months so researchers could examine the effectiveness of this testosterone depot at preventing pregnancy.  The contraceptive was able to achieve a sperm count below the threshold of fertility at 52 days on average.  Eight men could not reach the threshold and were excluded from the study.  42 other men dropped out.  Men from Oriental countries were more likely to achieve azoospermia than Western men (95% vs. 68%).  11 pregnancies occurred all of which involved men with a low sperm count (<or= 3 million/ml).  Among men with a low sperm count the pregnancy rate was 1.4% which is better than that for current methods of reversible male contraception.  Side effects were rare and were mainly limited to mood changes and acne.  The participation of the men in the study demonstrated that they can be as committed to family planning as women.
Case 36-1986
Authors: Richard C. Cabot, Robert E. Scully, Eugene J. Mark, Betty U. McNeely, Theodore L. Munsat, Edward P. Richardson, Robert H. Brown
Journal: New England Journal of Medicine (1986)

Presentation of CaseA 29-year-old woman was admitted to the hospital because of weakness of proximal muscles.She was born of a normal gestation and delivery. She rolled over and sat up at normal times but was slightly slow to walk. Throughout her early childhood she had short Achilles tendons, particularly on the left side; she tended to run on her toes and could not stand with either foot flat against the ground. Persistent plantar flexion made it difficult for her to keep her feet in the stirrups when she was riding a horse. At the age of 12 years . . .
On Desire, Excitement, and Impotence in Modern Sex Therapy
Authors: Walter Vandereycken
Journal: Psychotherapy and Psychosomatics (1987)

The widely accepted DSM-III classification of sexual dysfunctions has reinforced the idea that it concerns easily distinguishable deficiencies in the 'normal' phases of the sex response cycle: desire, excitement, and orgasm. For each of these deficiencies sex therapists offer a standard treatment package by which clients can learn to restore the 'natural' response pattern. As such, treatment has become a matter of techniques and so has sexuality itself. Acting as psychotechnologists, many sex therapists show an almost insatiable 'desire' to improve their clients' sexual performance and they experience the 'excitement' of their therapeutic work in counting the number of orgasms their clients are able to reach. But facing the problem of inhibited sexual desire, a lot of sex therapists must admit their 'impotence' in this matter. What they do not seem to realize is that their performance-oriented approach enhances a sociocultural climate in which people lose interest in preprogrammed sex, because sexual lust has turned from a taboo into a 'must'.
SOME ORIGINAL STUDIES ON THE OBSTETRICAL FORCEPS, WITH MECHANICAL DEMONSTRATIONS.
Authors: J. J. E. MAHER
Journal: JAMA (1895)

The obstetrical forceps is essentially a conservative agent, and by saving two lives at once, becomes the most useful instrument in surgery. It therefore well deserves the immense amount of ingenuity that has been expended in attempts to eliminate the defects discovered in the common or ordinary forceps. I shall proceed in the simplest possible manner, and leave all abstruse calculations and<i>"Reine Mechanik,"</i>to be read rather than listened to. For a workman to understand the character of the tool he requires, it is absolutely necessary for him to be able to appreciate the character of the work to be done. He must learn the conditions and the exigencies of them, before he can calculate the amount of force to be expended and the manner of its application to accomplish the work in hand. By work, I mean the application of force to overcome resistance. To understand this resistance
Moderate Alcohol Consumption and Risk of Heart Failure Among Older Persons
Authors: Jerome L. Abramson
Journal: JAMA (2001)

Heavy consumption of alcohol can lead to heart failure, but the relationship between moderate alcohol consumption and risk of heart failure is largely unknown.To determine whether moderate alcohol consumption predicts heart failure risk among older persons, independent of the association of moderate alcohol consumption with lower risk of myocardial infarction (MI).Prospective cohort study conducted from 1982 through 1996, with a maximum follow-up of 14 years.Population-based sample of 2235 noninstitutionalized elderly persons (mean age, 73.7 years; 41.2% male; 21.3% nonwhite) residing in New Haven, Conn, who were free of heart failure at baseline. Persons who reported alcohol consumption of more than 70 oz in the month prior to baseline were excluded.Time to first fatal or nonfatal heart failure event, according to the amount of alcohol consumed in the month prior to baseline.Increasing alcohol consumption in the moderate range was associated with decreasing heart failure rates. For persons consuming no alcohol (50.0%), 1 to 20 oz (40.2%), and 21 to 70 oz (9.8%) in the month prior to baseline, crude heart failure rates per 1000 years of follow-up were 16.1, 12.2, and 9.2, respectively. After adjustment for age, sex, race, education, angina, history of MI and diabetes, MI during follow-up, hypertension, pulse pressure, body mass index, and current smoking, the relative risks of heart failure for those consuming no alcohol, 1 to 20 oz, and 21 to 70 oz in the month prior to baseline were 1.00 (referent), 0.79 (95% confidence interval [CI], 0.60-1.02), and 0.53 (95% CI, 0.32-0.88) (P for trend =.02).Increasing levels of moderate alcohol consumption are associated with a decreasing risk of heart failure among older persons. This association is independent of a number of confounding factors and does not appear to be entirely mediated by a reduction in MI risk.