tbuckley/cabot-search huggingface dataset:
Patient's experience
Authors: Colin John Rees
Journal: BMJ (2006)

It was terrifying waking up in intensive care.1 I didn't know where I was or what had been done. In particular, having the balloon in my mouth was terrifying. This frightened me into discharging myself. I was so frightened at the thought I might die, and I wanted to be in familiar surroundings and hoped I would be OK.

I know alcohol is harming me, but I like to drink and enjoy the feeling it gives me. It's also escapism, particularly as I am a worrier. I feel well after a spell in hospital and think I'm OK to go back to drinking again. I don't think professionals could do more to help me stop drinking. It's down to me. They can't make me do what I don't want to do.

I feel that I can stop if I want to. I did stop for a year after my first time in hospital five years ago. I know I should stop drinking as I know all the risks and problems. My girlfriend is the reason why I should stop really. This and my family issues upset me, and although they should make me stop, they are one of the reasons I keep drinking.

I have been treated well by my general practitioner and by medical, nursing, and other staff. I don't ever feel I've been discriminated against because of my drinking. That is one of the reasons I am happy to contribute to this discussion—I would like to help in return.

I know there is debate about how much treatment patients like me should get. I think that if I continue to bleed then I should get treatment to stop the bleed because ultimately what happens to me if there is a limit placed on my treatment—do you let me bleed to death? I don't think that I should receive a liver transplant if I continue to drink—liver transplants should go to the really needy. Patients who stop drinking shouldn't get liver transplants either.
Presentation of Diagnostic Test Accuracy
Authors: Mike Broce, Bernardo Reyes
Journal: Annals of Internal Medicine (2006)

Letters7 February 2006Presentation of Diagnostic Test AccuracyMike Broce, BS and Bernardo Reyes, MDMike Broce, BSFrom CAMC Institute, Charleston, WV 25304.Search for more papers by this author and Bernardo Reyes, MDFrom CAMC Institute, Charleston, WV 25304.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-144-3-200602070-00019 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:We agree with Dr. Puhan and his colleagues (1) that it is essential for physicians to interpret the real value of diagnostic testing to confirm clinical suspicions so that a better practice of medicine can occur. After reading their conclusions, we believe that replication of their results is needed, perhaps with a few modifications. Our suggestions are not intended to diminish the findings of what we consider to be an excellent study.Although a table for the clinical vignettes was provided, it was not clear if equations to calculate illness probability changes were provided to surveyed physicians. ...Reference1. Puhan MA, Steurer J, Bachmann LM, ter Riet G. A randomized trial of ways to describe test accuracy: the effect on physicians' post-test probability estimates. Ann Intern Med. 2005;143:184-9. [PMID: 16061916] LinkGoogle Scholar Author, Article, and Disclosure InformationAuthors: Mike Broce, BS; Bernardo Reyes, MDAffiliations: From CAMC Institute, Charleston, WV 25304.Disclosures: None disclosed. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoA Randomized Trial of Ways To Describe Test Accuracy: The Effect on Physicians' Post-Test Probability Estimates Milo A. Puhan , Johann Steurer , Lucas M. Bachmann , and Gerben ter Riet Presentation of Diagnostic Test Accuracy Daniel J. Brotman Presentation of Diagnostic Test Accuracy Milo A. Puhan , Johann Steurer , and Gerben ter Riet Metrics 7 February 2006Volume 144, Issue 3Page: 220-221KeywordsConflicts of interestDiagnostic medicineForecastingMedical conditionsReproducibility ePublished: 7 February 2006 Issue Published: 7 February 2006 Copyright & PermissionsCopyright © 2006 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Plasma oxytocin during third stage of labour: comparison of natural and active management.
Authors: S. Thornton, J. M. Davison, P. H. Baylis
Journal: BMJ (1988)

The incidences of postpartum haemorrhage and retained placenta have decreased with the use of synthetic oxytocin and controlled cord traction. Whether such treatment is valuable is open to question because of the lack of clinical and physiological studies. The physiological effects of synthetic oxytocin on plasma concentrations of oxytocin and events during delivery were assessed. Plasma oxytocin concentration was determined in serial samples during the late second stage and throughout the third stage of labour in 25 women. Ten women received combined ergotamine and synthetic oxytocin intramuscularly and 15 were not treated. The geometric mean plasma oxytocin concentration significantly increased in the women given oxytocin when measured before and after delivery of the fetal anterior shoulder (3.1 (SD 2.0) pmol/l before and 15.9 (2.7) pmol/l after). Six of the women who did not receive treatment showed a significant increase in geometric mean plasma oxytocin concentration before and after delivery of the fetal shoulder (3.2 (2.0) pmol/l before and 6.4 (2.0) pmol/l after) and nine did not show an increase (geometric mean 2.4 (3.1) pmol/l before and 2.2 (2.2) pmol/l after). Of these nine women, two had an abnormal third stage of delivery; one woman had a postpartum haemorrhage and one required manual removal of the placenta. As it is impossible to predict which women will show a rise in the plasma concentration of endogenous oxytocin, intramuscular oxytocin should be given routinely.
Binding and internalization of somatostatin, insulin, and glucagon by cultured rat islet cells.
Authors: M Amherdt, Y C Patel, L Orci
Journal: Journal of Clinical Investigation (1989)

The pathways by which islet B, A, and D cells bind and internalize homologous (self) and heterologous (other) islet hormones were compared. [125I-Tyr]Somatostatin-14 (S-14), 125I-insulin, and 125I-glucagon were incubated with monolayer cultures of neonatal rat islet cells. Tissues were processed for quantitative electron microscopic autoradiography by the probability circle method coupled to morphometry. For all three radioligands and all three cell types surface labeling was rapidly followed by internalization of the radioligands into endocytotic vesicles. The further intracellular movement of the ligand occurred in a time- and temperature-related manner and depended on whether it was homologous or heterologous for the cell in question. Thus [125I-Tyr]S-14 in B and A cells, 125I-insulin in A and D cells, and 125I-glucagon in B and D cells were rapidly transferred from endocytotic vesicles to lysosomal structures. By contrast, [125I-Tyr]S-14 in D cells, 125I-insulin in B cells, and 125I-glucagon in A cells showed poor progression from endocytotic vesicles to downstream vesicular structures. We conclude that (a) each of the three radioligands is internalized by islet cells in a time- and temperature-dependent manner; (b) after initial internalization the further intracellular progression of the endocytosed radioligand occurs freely in cells heterologous for the radioligand but poorly in cells homologous for the radioligand; and (c) binding and endocytosis can be uncoupled from lysosomal degradation of ligand.
MEDICAL EDUCATION FOR THE GENERAL PRACTITIONER
Authors: WILLIAM J. MAYO
Journal: JAMA (1927)

In the autumn of life one perhaps may be privileged to become reminiscent. A brief review of my own medical college experiences and lifelong attempts to improve my knowledge by visits to the great medical clinics of the world may aid in an interpretation of my personal views of present-day methods of medical education. In 1880 after high school, two years in Niles Academy, and one year in a private school for languages and sciences, I entered the medical department of the University of Michigan. I graduated in 1883, when I was 21. The year 1880 marked the commencement at the University of Michigan of a medical course of three years, with nine months to the school year. The three-year course was an innovation which at that time had been adopted by but few medical schools in this country. Most of the schools still gave a two-year course of five
14 EFFICACY AND SAFETY OF WEIGHT-BASED REGIMENS OF TARIBAVIRIN OR RIBAVIRIN, GIVEN WITH PEGINTERFERON ALFA-2B, AT 12 WEEKS AFTER TREATMENT (SVR12) IN NAIVE PATIENTS WITH GENOTYPE 1 CHRONIC-HEPATITIS C
Authors: F. Poordad, E. Lawitz, R. Pozza, M. Shiffman, B. Bacon, E. Godofsky, D. Halliman, J. Heise, E. Chun, J. Hammond
Journal: Journal of Hepatology (2009)
DIET AND DISEASE IN NATIVE RACES IN THE TROPICS
Authors: R. McCarrison
Journal: BMJ (1931)

WALES in the chair.A message from the King expressed his pleasure at the increased distribution in 1930, and the hope that the public would realize the importance of maintaining the income of the King's Fund and of the hospitals during the present difficult times.His Royal Highness stated that the distribution in 1930 wvas £266,000, as compared with £250,000 in the previous year.A gift of £2,000 had been made by the Nizam of Hyderabad, and the British Charities Association had allotted £10,000 for the London hospitals.The year 1931, so far as it had gone, was proving even more difficult than 1930 ; there was an increase in the number of hospital deficits, but, on the other hand, it should be remembered that the finances of the voluntary hospitals generally before the present crisis had been steadily im- proving.The difficulties they were now facing, added the Prince, were due to world-wide depression, and not to any weakness in the voluntary system itself.The report of
Primary plasmacytoma at the site of exit wounds after electrical injury
Authors: Wichean Mongkonsritragoon, Robert A. Kyle, Robert R. Shreck, Philip R. Greipp
Journal: American Journal of Hematology (1998)

We report a case of primary plasmacytoma occurring 12 years after electrical injury. Roentgenograms showed multiple well-circumscribed lytic lesions involving both the right and left tibial diaphyseal regions. Bone biopsy from the left tibial region showed sheets of monoclonal myeloma cells. No evidence of multiple myeloma was found. The patient was treated with local radiation to both tibias and had no evidence of recurrence 6 years later. In conclusion, we report the first case of primary plasmacytoma of both tibias that occurred after electrical injury 12 years before. Am. J. Hematol. 58:77–79, 1998. © 1998 Wiley-Liss, Inc.
Spiritus Frumenti Strikes Another Sour Note
Authors: RONALD A. ARKY
Journal: Annals of Internal Medicine (1973)

Editorials1 February 1973Spiritus Frumenti Strikes Another Sour NoteRONALD A. ARKY, M.D.RONALD A. ARKY, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-78-2-297 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptOlder concepts that most of the clinical features of alcoholism result from derangement of hepatic or pancreatic function need to be changed. More recognition must be given to the fact that, with the oxidation of ethanol, specific pathways in the intermediary metabolism of carbohydrate, protein, and lipid are altered. Such effects may be independent of structural changes in the liver or other vital organs. In recent years several reviews concerned with the interplay between the metabolism of ethanol and that of the several foodstuffs have appeared (1, 2). In addition, ethanol induces hepatic microsomal enzyme systems and consequently may alter...References1. LIEBER C: Metabolic effects produced by alcohol in the liver and other tissues. Adv Intern Med 14:151-199, 1968 MedlineGoogle Scholar2. MENDELSON J: Biologic concomitants of alcoholism. N Engl J Med 283:24-32, 1970 CrossrefMedlineGoogle Scholar3. KREISBERGOWENSIEGAL RWA: Ethanol-induced hyperlacticacidemia: inhibition of lactate utilization. J Clin Invest 50:166-174, 1971 CrossrefMedlineGoogle Scholar4. LEFÈVREADLERLIEBER AHC: Effect of ethanol on ketone metabolism. J Clin Invest 49:1775-1782, 1970 CrossrefMedlineGoogle Scholar5. JENKINSECKLECRAIG DRJ: Alcoholic ketoacidosis. JAMA 217:177-183, 1971 CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Division of Medicine Mount Auburn Hospital Cambridge, Mass. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 February 1973Volume 78, Issue 2Page: 297-298KeywordsAlcoholismCarbohydrate metabolismCarbohydratesEnzymesEthanolLipidsLiverProtein metabolism Issue Published: 1 February 1973 PDF DownloadLoading ...
A Concept of Analytical Treatment for Patients with Psychosomatic Disorders
Authors: S. Stephanos
Journal: Psychotherapy and Psychosomatics (1975)

With the Paris school the author holds the view that the 'pensée opératoire' is pathognomic for the psychosomatic patient. This archaic, 'automatistisch-mechanistisch' thinking is a consequence of defects in the sphere of the physiological pre-ego. Certain typical findings, such as reduplication and mechanized object relations are seen as correlates of disturbances in the patient's early identification processes. Analytical therapy must thus aim at shifting the all but inaccessible psychosomatic phenomenon into a historical perspective. The psychological event can set in only when the patient has discovered the connexion between his somatic reaction patterns and the emotions he is beginning to feel for the security-giving therapist. An account of the development of the treatment of one patient (Birgit) illustrates the author's concept of analytical therapy in psychosomatics. The 'facilitating environment' helped the patient Birgit to differentiate herself from her dual object and thus to be able to cathect the level of the triangular relationship. The concept of the model ward led on to the development of an ambulatory method of therapy, 'relaxation analytique', which is based on investigations into the concept of the holding function. 'Taking care' of the patient is function of the therapist's own inner attitude, of his being prepared to do everything to encourage the therapeutic regression. The correlate of this attitude, on the side of the patient, is the sense of security which is an essential condition for the 'new beginning' to set in.
Interleukins in Churg‐Strauss syndrome
Authors: M. Kurosawa, R. Nakagami, J. Morioka, H. Inamura, Y. Mizushima, N. Sugawara, T. Yamashita, T. Yokoseki, S. Kitamura, Y. Omura, M. Shibata, J. Chihara
Journal: Allergy (2000)
Is the Routine Use of Inhaled β-Adrenergic Agonists Appropriate in Asthma Treatment?: No
Authors: Malcolm R. Sears
Journal: American Journal of Respiratory and Critical Care Medicine (1995)

"Is the Routine Use of Inhaled β-Adrenergic Agonists Appropriate in Asthma Treatment?: No." American Journal of Respiratory and Critical Care Medicine, 151(3_pt_1), pp. 600–601
The Attempted Assassination of President Reagan
Authors: B L Aaron, S D Rockoff
Journal: JAMA (1994)

In 1981, President Ronald Reagan became the first incumbent president of the United States to survive being struck by a would-be assassin's bullet. Had President Reagan not survived, the history of this country and the world most certainly would have been changed. This report is the only first-hand account of the details of his medical care and complications following the assassination attempt, an event that emphasizes the vulnerability of presidents to would-be assassins and the importance of readily available expert medical care and facilities to their survival. (<i>JAMA</i>. 1994;272:1689-1693)
Law and Ethics in the Practice of Psychiatry
Authors: Robert L. Sadoff
Journal: JAMA (1981)

This highly readable book, produced by the American College of Psychiatrists and edited by the late Dr Hofling, contains a number of papers by eminently qualified and well-selected individuals. Each of the chapters is well written and focuses clearly on ethics in psychiatry. Some ethical issues have legal implications, and all legal issues have ethical over-tones. The book is divided into four sections. The first deals with the historical perspectives on law and mental health reflecting the recent changes in the system and also on ethics in psychiatry throughout the history of the profession. The second section is composed of clinical issues and deals primarily with privacy and confidentiality, informed consent and disclosure of information, and duty to warn, especially under the<i>Tarasoff</i>ruling. These three chapters are written by three of the country's experts and deal with the legal issues in a manner reflecting the ethics of psychiatry. The
Instantaneous measurement of left and right ventricular stroke volume and pressure-volume relationships with an impedance catheter.
Authors: R G McKay, J R Spears, J M Aroesty, D S Baim, H D Royal, G V Heller, W Lincoln, R W Salo, E Braunwald, W Grossman
Journal: Circulation (1984)

The feasibility of using continuous on-line recording of intraventricular electrical impedance to measure ventricular stroke volume was assessed in 12 patients at cardiac catheterization with a multielectrode impedance catheter and a 1.3 kHz measuring current of 4 microA. Stroke volumes determined by electrical impedance were compared with stroke volumes determined by the thermodilution technique in 10 patients and correlated with an r value of .95. Directional changes in impedance recordings throughout the cardiac cycle were also compared with volume curves obtained from six patients by radionuclide ventriculography, and in all instances the agreement between the two volume recordings was excellent. For all patients, on-line measurements of impedance showed a beat-by-beat decrease in stroke volume with the Valsalva maneuver and the administration of amyl nitrite, as well as an immediate increase in stroke volume in the contraction following an extra-systolic beat. Similar directional changes in stroke volume were recorded in both left and right ventricles. Left ventricular pressure-volume relationships were assessed with simultaneous left ventricular pressure recordings and volume signals recorded from the impedance catheter to determine if impedance measurements of volume can be used clinically. Pressure-volume diagrams were subsequently plotted, and for all patients these diagrams showed characteristic isovolumetric contraction and relaxation phases as well as typical ejection and filling periods. Moreover, beat-by-beat sequential pressure-volume diagrams constructed for patients during the administration of amyl nitrite revealed a linear end-systolic pressure-volume relationship.(ABSTRACT TRUNCATED AT 250 WORDS)
The use of injectable spherically symmetric cell aggregates self-assembled in a thermo-responsive hydrogel for enhanced cell transplantation
Authors: Wen-Yu Lee, Yu-Hsiang Chang, Yi-Chun Yeh, Chun-Hung Chen, Kurt M. Lin, Chieh-Cheng Huang, Yen Chang, Hsing-Wen Sung
Journal: Biomaterials (2009)
624 DIAGNOSIS OF BACTERIAL PERITONITIS BY IDENTIFICATION OF 16S RRNA GENES VIA POLYMERASE CHAIN REACTION (PCR)
Authors: J. Hartmann, S. Krohn, F. van Bömmel, B. Fülöp, A. Brodzinski, J. Wiegand, H. Wittenburg, S. Böhm, J. Mössner, T. Berg
Journal: Journal of Hepatology (2012)
Abstract 1068: Cooperation between BRCA1 and Aurora A kinase regulates <i>in vitro</i> crisis in epithelial cells derived from benign ovarian tumors
Authors: Christine M. Marion, Louis Dubeau, Vanessa Yu
Journal: Cancer Research (2010)

Abstract Aneuploidy, as defined by a chromosome number that is not a multiple of the haploid number, is a hallmark of cancer. We used an in vitro cell culture model where explants of benign epithelial ovarian tumors (cystadenomas) were transfected with an expression vector for SV40 Large T Antigen, allowing bypass of senescence due, in part, to p53 and Rb inhibition by this antigen. We previously showed that such cells eventually reach a crisis event that is associated with a cell cycle arrest at the M phase and is independent of telomere attrition. Cells that recover from this event do not complete cytokinesis and become polyploid, which is a precursor to aneuploidy. Decreased BRCA1 expression facilitates abrogation of mitotic arrest, leading to increased rates of aneuploidy. We hypothesized that Aurora A plays a role in regulating this ploidy-associated crisis event by acting as an upstream regulator of BRCA1 expression. Here we show that Aurora A kinase activity and expression is up-regulated in cells approaching crisis. Over-expression of Aurora A resulted in decreased levels of BRCA1, resulting in increased tetraploidy and aneuploidy, secondary to cells overcoming a ploidy-associated crisis. Levels of BRCA1 expression increased upon knockdown of Aurora A kinase using siRNA, further suggesting an inverse relationship between expression levels of these two proteins. Inhibition of Aurora A in cultured ovarian cystadenomas approaching crisis led to decreased cell proliferation and a concomitant decrease in tetraploidy. We tested the hypothesis that this was associated with an increase in crisis-related apoptosis by knocking down Aurora A kinase using siRNA technologies in cells approaching crisis, followed by western blotting using antibodies against PARP and cleaved CASPASE 7 fragment. The results indeed showed increased levels of these two protein fragments upon Aurora A knockdown, indicating activation of a caspase-regulated apoptotic pathway. Our findings suggest a novel role for Aurora A's influence on BRCA1 expression levels in cells approaching ploidy dependent crisis. This may, in part, explain the increased rate of near polyploidy associated with high grade ovarian carcinomas and may provide insights into the mechanism underlying aneuploidy development in epithelial cancers in general. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 101st Annual Meeting of the American Association for Cancer Research; 2010 Apr 17-21; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2010;70(8 Suppl):Abstract nr 1068.