CLINICAL RESEARCH USING COMPOUNDS LABELED WITH RADIOACTIVE CARBON AND HYDROGEN AS TRACERS
Authors: G V LEROY
Journal: Annals of Internal Medicine (1955)

Article1 February 1955CLINICAL RESEARCH USING COMPOUNDS LABELED WITH RADIOACTIVE CARBON AND HYDROGEN AS TRACERSGEORGE V. LEROY, M.D.GEORGE V. LEROY, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-42-2-239 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptIsotopes can be used in clinical research in two principal ways: first, to simplify existing analytic or diagnostic methods; and second, to study phenomena that cannot be examined readily, if at all, by conventional biochemical methods. There is no really good reason for considering the first option less important than the second, especially if the use of radioisotopes permits one to do more work, or to do it more accurately. It is easy, however, to become fascinated with the technical or electronic aspects of isotopes to the extent that interest in the physiologic problem is subordinated. It is possible to...Bibliography1. BarclayEbertLeRoyMantheiRoth WRRHGVRWLJ: Distribution and excretion of radioactive isoniazid in tuberculous patients, J. A. M. A. 151: 1384, 1953. MedlineGoogle Scholar2. MurrayLangham AWH: A synthesis of nicotinic acid by halogen-metal exchange and its application to the preparation of isonicotinic-C14-acid hydrazide, J. Am. Chem. Soc. 74: 6289, 1952. CrossrefGoogle Scholar3. Clarke HT: A symposium on the use of isotopes in biology and medicine, 1948, The University of Wisconsin Press, Madison, pp. 3-15. Google Scholar4. Pinson EA: Water exchanges and barriers as studied by the use of hydrogen isotopes, Physiol. Rev. 32: 123, 1952. CrossrefMedlineGoogle Scholar5. BurchRoyThreefoot GECTSA: Some theoretical considerations of electrolyte space measured by the tracer method in intact man, J. Lab. and Clin. Med. 42: 34, 1953. MedlineGoogle Scholar6. Stetten D: On the metabolic defect in gout, Bull. New York Acad. Med. 28: 664, 1952. MedlineGoogle Scholar7. BishopGarnerTalbott CWJH: Pool size, turnover rate, and rapidity of equilibration of injected isotopic uric acid in normal and pathological subjects, J. Clin. Investigation 30: 879, 1951. CrossrefMedlineGoogle Scholar8. Adapted from figure 2 in Stetten's lecture, op. cit. Google Scholar9. CornforthHunterPopjak JWBDG: The biosynthesis of cholesterol from acetate, Arch. Biochem. and Biophys. 42: 481, 1953. CrossrefMedlineGoogle Scholar10. GouldLeRoyOkitaKabaraKeeganBergenstal RGGVGTJJPDM: Cholesterol metabolism. IV. The use of C14-labeled acetate to study cholesterol metabolism in man, J. Lab. and Clin. Med., in press. Google Scholar11. LeRoyGouldBergenstal GVRGDM: Cholesterol metabolism in patients with myxedema, in preparation. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Chicago, Illinois*Presented as a Morning Lecture at the Thirty-fifth Annual Session of the American College of Physicians, Chicago, Illinois, April 9, 1954.From the Department of Medicine and the Argonne Cancer Research Hospital, The University of Chicago. Nextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byClinical Applications of Radioactive Isotopes 1 February 1955Volume 42, Issue 2Page: 239-250KeywordsHospital medicine ePublished: 1 December 2008 Issue Published: 1 February 1955 Copyright & PermissionsCopyright, 1955, by The American College of PhysiciansPDF downloadLoading ...