tbuckley/cabot-search huggingface dataset:
Abstract 9341: Increased Expression of ATPase (Beta) During Late Preconditioning and Preserved Energetics During Low Flow Ischemia in Swine
Authors: Elizabeth A Ziemba, Rosemary Kelly, Jesus A Cabrera, Joseph Sikora, Herbert B Ward, Lorraine Anderson, Dirk J Duncker, Wim Sluiter, Edward O McFalls
Journal: Circulation (2010)
Abstract 2563: Association of Cardiac Arrest With Early Repolarization Pattern in Competitive Athletes
Authors: Luigi De Ambroggi, Francesco Furlanello, Valerio Giovinazzo, Tommaso Infusino, Pierpaolo Lupo, Sara Foresti, Guido De Ambroggi, Mario Pittalis, Hussam Ali, Elisabetta Bianco, Riccardo Cappato
Journal: Circulation (2009)
Microvolt T-Wave Alternans
Authors: Richard L. Verrier, Thomas Klingenheben, Marek Malik, Nabil El-Sherif, Derek V. Exner, Stefan H. Hohnloser, Takanori Ikeda, Juan Pablo Martínez, Sanjiv M. Narayan, Tuomo Nieminen, David S. Rosenbaum
Journal: Journal of the American College of Cardiology (2011)
The Incidence and Natural Course of Transfusion-Associated GB Virus C/Hepatitis G Virus Infection in a Cohort of Thalassemic Patients
Authors: Daniele Prati, Alberto Zanella, Patrizia Bosoni, Paolo Rebulla, Elena Farma, Claudia De Mattei, Carmen Capelli, Fulvio Mozzi, Domenico Gallisai, Carmelo Magnano, Caterina Melevendi, Girolamo Sirchia for th e Cooleycare Cooperative Group
Journal: Blood (1998)
Abstract 15482: Implementation of a Heart Failure Readmission Reduction Program: a Quality Improvement Study
Authors: Jennifer Rabbat, Daniel Bashari, Rajnish Khillan, Manisha Rai, Jose Villamil, Chase Miller, Saumya Saini Saini, Archana Saxena
Journal: Circulation (2011)

Introduction Of all medical readmissions within 30 days, congestive heart failure (CHF) accounts for 26.9%, making it the number one cause of hospital readmissions within 30 days. There has been a ...
Increased Susceptibility in Hp Knockout Mice During Acute Hemolysis
Authors: Sai-Kiang Lim, Hongkyun Kim, Shen Kiat Lim, Azhar bin Ali, Yew Koon Lim, Yanping Wang, Siew Meng Chong, Frank Costantini, Heinz Baumman
Journal: Blood (1998)
Abstract 1882: Use of Speckle Tracking to Quantify Global LV Function: A Comparison with 2D and 3D Echo and Magnetic Resonance Imaging
Authors: Joseph K Brown, Thomas H Marwick
Journal: Circulation (2007)

Background: Ejection fraction (EF) plays a prominent role in clinical decision making but this calculation is time-consuming and dependent on load and geometry. A simple and quick technique for assessing global LV function would be useful. We sought to evaluate the robustness of global longitudinal strain (GLS) for assessment of LV function in comparison to Simpsons biplane ejection-fraction (2D-EF), 3D ejection fraction (3D-EF) and MRI ejection fraction (MRI-EF). We further investigated the automated measures of EF (auto-EF) from wall tracking. Methods: 2D and 3D echo and MRI measurement of EF were performed in 53 pts with previous infarction. GLS was measured by offline speckle-tracking in the apical 4C and 2C views. Abnormal curves were excluded on the basis of visual assessment. Auto-EF was calculated using the method of discs, using the traced endocardial border to establish end-diastolic and end-systolic volumes. Results: Average global TQ (tracking quality) was 1.14±0.22, permitting reliable derivation of strain from all segments. GLS showed a significant linear correlation with MRI-EF, similar to that between 3D-EF and MRI and better than that between 2D-EF and MRI and automated EF and MRI (Table ). Of 26 pts with a normal MRI-EF (≥50%), 85% had GLS within normal limits and 81% had normal 3D-EF, but significantly fewer were recognized as normal by 2D-EF (Table ). In pts with ≤5 abnormal segments, 3D-EF was the most accurate modality for assessing global LV function, while GLS was better than 2D-EF and auto-EF. In pts with &gt;5 abnormal segments, GLS was the most accurate modality of quantifying global LV function against MRI-EF (r = −0.83, p &lt;0.0001), comparatively better than 3D-EF against MRI-EF (r = 0.75, p &lt;0.0001). Conclusion: GLS is an effective method of quantifying global LV function. In pts with &gt;5 abnormal segments, GLS offered the best correlation with MRI-EF, reflecting the benefit of a geometry independent and site-specific parameter.
Abstract 2963: Association of Race and Socioeconomic Position with Graft Failure in Heart Transplant Recipients
Authors: Tajinder P Singh, Michael Givertz, Marc Semigran, Fred Costantino, David DeNofrio, Kimberlee Gauvreau
Journal: Circulation (2008)

Race has been associated with patient survival in heart transplant (HT) recipients. We hypothesized that this association is mediated by socioeconomic (SE) factors. Block groups (average population 1000) are the smallest units of population in US census database with available SE data. We assessed whether SE position, determined for the block group of patient residence at time of HT, is associated with graft failure in HT recipients. We used the US census 2000 database to extract 6 SE variables of wealth, income, education and occupation and calculated a previously validated summary SE score for 520 patients who underwent first HT at one of 4 Boston centers during 1996–2005. Cox proportional hazards modeling was used to compare the risk of graft failure (time to death or re-transplant) in the lowest quartile SE group (low SE group, n = 129) with that of remaining patients (controls, n = 391). Low SE patients were younger (median age 48 yrs versus 52 yrs for controls, P &lt; 0.015) and more likely to be nonwhite (32% versus 9% of controls, P = 0.001). The two SE groups were similar with respect to gender, listing status, cardiac diagnosis, hemodynamic support, year of HT and prevalence of diabetes, smoking and hypertension. Graft failure occurred in 142 HT patients (135 deaths, 7 re-transplants). Early Graft failure (within 6 months) was associated with earlier era (before 2001), pre-HT extracorporeal membrane oxygenation or ventricular assist device but not with age, cardiac diagnosis, race or low SE position. In patients who survived at least 6 months (conditional survival), nonwhite race (HR 2.0, 95% CI 1.3–3.3, P = 0.004), low SE position (HR 1.6, CI 1.1–2.5, P = 0.03) and pre-HT smoking (HR 1.6, CI 1.0 –2.4, P = 0.03) were all associated with subsequent graft failure. In multivariable analysis, nonwhite race (HR 1.9, CI 1.2–3.3) remained a significant predictor of late graft failure after controlling for low SE position (HR 1.3, CI 0.8 –2.1, P = 0.24) and pre-HT smoking (HR 1.6, CI 1.1–2.5, P = 0.03). There is no association of early post-HT survival with race or low SE position. Nonwhite race is associated with increased risk of death or re-transplant after 6 months of HT. Low SE position explains only a small fraction of this association.
Abstract 16986: A New Cardiac Muscle Post-Translational Modification: Detection of Protein Arginine Deiminases and Protein Citrullination in Heart Tissue
Authors: Justyna Fert-Bober, Helge Uhrigshardt, Marc Halushka, Felipe Andrade, Jon Giles, Joan Bathon, Jennifer Van Eyk
Journal: Circulation (2011)

ABSTRACT: Protein citrullination originates from enzymatic deimination of amino acid arginine in a protein and is involved in various biological processes during health and disease. However, it has not been investigated in heart. Therefore, our goal was to identify novel substrates for peptidylarginine deiminase (PAD), enzyme responsible for this modification and associate it with changes in protein citrullination during heart failure (HF). METHODS: Proteomics methods were used to identify citrullinated proteins and the site of modification in control mouse and control vs. HF human heart tissue (5 per group). The characterization of deiminated proteins was facilitated by modification of peptide-bound citrullineted Arg residues with antipyrine and butanedione, allowing for the unambiguous identification by mass spectrometry. Verification of citrullinated proteins was carried out by 2DE (modification causes pI shift) and western blot with anti-citrullinated antibody. PAD enzyme expression was determined using RT-PCR reaction and immunohistochemistry. RESULTS: We detected up to 20 proteins markedly modified by PAD in vitro and in vivo in mouse heart including myofilament and mitochondria proteins. Similar proteins were identified to be citrullinated in control human heart tissue including tropomyosin (R220), myosin heavy and light chain (R1176, 1434 and 1479) and myosin binding protein C (R696). Importantly, we showed a specific residues deimination associated with the HF, e.g. tropomyosin from HF samples has 3 different citrullinated sites (R 125, 133, 238) compared to control. The PAD enzyme is present in mouse isolated cardiomyocytes and cardiac fibroblast (predominantly PAD2 vs. PAD2/PAD4, respectively). Immunohistochemistry of control human hearts had positive PADs staining in cardiomyocytes. CONCLUSIONS: Our study demonstrates, for the first time that protein citrullination is a viable post-translational modification in heart tissue and corresponds to the cardiac expression of PAD. Furthermore we showed that citrullinatated residues are altered HF suggesting that this novel PTM could have a regulatory role.
Evidence for the independent familial transmission of attention deficit hyperactivity disorder and learning disabilities: results from a family genetic study
Authors: S V Faraone, J Biederman, B K Lehman, K Keenan, D Norman, L J Seidman, R Kolodny, I Kraus, J Perrin, W J Chen
Journal: American Journal of Psychiatry (1993)

The purpose of the study was to clarify the relationship between attention deficit hyperactivity disorder and learning disabilities.The authors assessed learning disabilities in a sample of 140 children with attention deficit hyperactivity disorder and in 120 normal comparison children. They also assessed a sample of the probands' 822 first-degree relatives.The risk for learning disabilities was highest among relatives of probands with both attention deficit hyperactivity disorder and learning disabilities. The two disorders did not cosegregate in families. There was nonrandom mating between spouses with attention deficit hyperactivity disorder and learning disabilities.The two disorders are transmitted independently in families, and their co-occurrence may be due to nonrandom mating. Attention deficit hyperactivity disorder is likely to be etiologically independent from learning disabilities.
A survey of MAPK pathway signature activation in tumors and association with sensitivity to targeted therapies
Authors: Daniel Rhodes, Wendy Lockwood Banka
Journal: Clinical Cancer Research (2008)

AACR Centennial Conference: Translational Cancer Medicine-- July 20-23, 2008; Monterey, CA

A6 

Gene expression signatures have been demonstrated to predict pathway activity in tumors and sensitivity to targeted therapies. Here, we generated MAPK pathway activation signatures from in vitro gene expression data and studied their association with a wide spectrum of cancer subtypes and drug sensitivity phenotypes. Our analysis utilized the Oncomine Concepts Map, a molecular signatures database that includes more than 25,000 microarray experiments and more than 2,000 highly curated differential expression analyses. As expected, when considering other in vitro pathway activation signatures, the MAPK pathway activation signature was most strongly associated with an independent H-Ras activation signature. Furthermore, the MAPK signature was significantly associated with a number of tumor types that are known to have MAPK pathway activation, including pancreatic tumors, which typically harbor K-Ras activating mutations and glioblastoma, which often harbor EGFR amplifications, suggesting that novel associations may indicate additional tumor types with MAPK pathway activation. Several tumor subtypes were also found to have increased MAPK pathway activity including: estrogen receptor negative breast cancer, BCR/ABL acute lymphoblastic leukemia, IgH/FGFR3 multiple myeloma, K-Ras mutant lung adenocarcinoma and PDGFRa mutant gastrointestinal stromal tumors. MAPK pathway activation also showed a striking correlation with poor outcome across a variety of solid tumor types including bladder, brain, breast, ovarian and kidney. When considering drug sensitivity phenotypes, we found a near universal association between MAPK pathway activation and resistance to conventional chemotherapeutic agents in cancer cell lines. In contrast, MAPK pathway activation was significantly associated with sensitivity to both dasatinib and gefitinib, in breast and lung cancer cell lines, respectively. In summary, our study suggests that hyper-activation of the MAPK pathway is evident in specific tumor types and subtypes and may be a driver of poor prognosis and chemotherapy resistance, providing an opportunity for new pathway-specific targeted therapies.
Abstract 12565: Right Ventricle 18FDG Uptake in Pulmonary Hypertension: A New Biomarker
Authors: Wei Fang, Lan Zhao, Changming Xiong, Jianguo He, Martin R Wilkins
Journal: Circulation (2010)

Myocardial hypertrophy is associated with an increase in myocardial glucose uptake. This study assessed myocardial glucose uptake in the right ventricle (RV) of patients with pulmonary hypertension...
Abstract 10439: Natural History of Echolucent Plaque in Stable Patients with Coronary Artery Disease: Insights From Intravascular Ultrasound
Authors: Yu Kataoka, Amy Hsu, Kathy Wolski, Kiyoko Uno, Rishi Puri, E.Murat Tuzcu, Steven E Nissen, Stephen J Nicholls
Journal: Circulation (2011)

Background: Large lipid cores are frequently found in vulnerable plaques with a high propensity to rupture and promote acute ischemia. Echolucent plaques (ELP) reflecting lipid cores are often obse...
Genetic counseling for psychiatric patients and their families
Authors: M T Tsuang
Journal: American Journal of Psychiatry (1978)

The author presents an overview of genetic counseling for psychiatric patients and their families, including a brief summary of contemporary research into the evidence of genetic factors, the familial risks, and the possible modes of inheritance for major psychiatric disorders. The purpose is to review and condense the available literature pertaining to psychiatric genetic counseling for the benefit or psychiatrists and counselors in their day-to-day practice and for the general "consumer." It is hoped that giving the general public access to such information will help to reduce the suffering commonly brought about by the stigmatization of mental disorders.
Mite allergen–specific IgE is detectable in bronchial secretions of patients with nonatopic asthma and correlates with mucosal expression of periostin
Authors: Jonathan Mouthuy, Sophie Viart, Maha Z. Ladjemi, Bruno Detry, Monique Henket, Claus Bachert, Renaud Louis, Charles Pilette
Journal: Journal of Allergy and Clinical Immunology (2015)
Treating mentally disordered prisoners
Authors: R W K Reeves
Journal: BMJ (1995)

EDITOR,--“The numbers of untreated psychotic men in prison will grow,” state H Needham-Bennett and I Cumming.1 In the late 1950s the doors of local mental hospitals were unlocked and Broadmoor Hospital became so overcrowded that it was difficult to run a therapeutic regime. The private hospitals, starting with St Andrew's in Northampton, then expanded and absorbed many patients who needed some security. The private hospitals were followed by the regional secure units, which in their turn absorbed many patients who were difficult …
Intestinal parasites isolated in a large teaching hospital, Italy, 1 May 2006 to 31 December 2008
Authors: L Masucci, R Graffeo, S Bani, F Bugli, S Boccia, N Nicolotti, B Fiori, G Fadda, T Spanu
Journal: Eurosurveillance (2011)

Binary file ES_Abstracts_Final_ECDC.txt matches
Abstract 907: Plaque Burden at Left Main Coronary Artery of Patients Undergoing Percutaneous Coronary Intervention with Metabolic Syndrome
Authors: Motohiro Miyagi, Hideki Ishii, Tetsuya Amano, Tadayuki Uetani, Satoshi Isobe, Ryuichiro Murakami, Tatsuaki Matsubara, Toyoaki Murohara
Journal: Circulation (2008)

Background: The left main coronary artery (LMCA) is an important target of atherosclerotic plaque accumulation. The purpose of this study is to investigate the relationship between metabolic syndrome and plaque characteristics at LMCA. Methods: We enrolled 63 consecutive patients with stable angina who underwent percutaneous coronary intervention (PCI). Using intravascular ultrasound (IVUS), cross-sectional area (CSA), lumen area and plaque area were checked at LMCA undergoing PCI for the left anterior descending coronary artery or left circumflex coronary artery but not LMCA. Total plaque volume at LMCA was also checked by IVUS. The tissue characteristics of coronary plaque at LMCA was analyzed and quantified using integrated backscatter (IB) IVUS. The patients were devided into the two groups who had metabolic syndrome (n = 34) or not (n = 39). We evaluated the relationship between plaque burden at LMCA and metabolic syndrome. Results: Patients with metabolic syndrome had significantly larger plaque area and CSA at minimum lumen area (MLA) of LMCA than patients without metabolic syndrome (10.8 ± 3.7mm2 vs 8.2 ± 4.4 mm2, p = 0.01, 25.8 ± 5.0mm2 vs 23.1 ± 5.4 mm2, p = 0.04, respectively). About total plaque volume at LMCA, patients with metabolic syndrome had also significantly larger volume than patients without metabolic syndrome (53.8 ± 24.7mm3 vs 39.8 ± 21.2 mm3, p = 0.021, respectively). Furthermore, the lipid component of plaque volume at LMCA using IB-IVUS was significantly larger in patients with metabolic syndrome than without metabolic syndrome (25.7 ± 12.1mm3 vs 19.3 ± 11.6 mm3, p = 0.038, respectively). Conclusion: These findings suggest that patients with metabolic syndrome have not only larger plaque but also lipid-rich plaque at LMCA than without metabolic syndrome. IVUS and IB-IVUS Parameter at LMCA
Abstract 3959: Exercise Blood Pressure and Long Term Mortality in a Population of Subjects without Known Cardiovascular Disease
Authors: Luciano Babuin, Jorge R Alegria, Joseph G Murphy, Randal J Thomas, Thomas G Allison
Journal: Circulation (2006)

Blood pressure is routinely measured during exercise testing, but data on its prognostic significance are limited. The present study asked whether maximum systolic blood pressure (MSBP) predicts lo...
Abnormalities of 16q in Multiple Myeloma Are Associated with Poor Prognosis: 500K Gene Mapping and Expression Correlations Identify Two Potential Tumor Suppressor Genes, WWOX and CYLD.
Authors: Matthew W. Jenner, Paola E. Leone, Brian A. Walker, David C. Johnson, Laura Chiecchio, Elisabet Dachs Cabanas, Gian Paolo Dagrada, Mathew Nightingale, Rebecca K.M. Protheroe, David Stockley, Monica Else, Fiona M. Ross, Nicholas C.P. Cross, Faith E. Davies, Gareth J. Morgan
Journal: Blood (2006)
Monocyte tissue factor induction by lipopolysaccharide (LPS): dependence on LPS-binding protein and CD14, and inhibition by a recombinant fragment of bactericidal/permeability-increasing protein
Authors: K Meszaros, S Aberle, R Dedrick, R Machovich, A Horwitz, C Birr, G Theofan, JB Parent
Journal: Blood (1994)
More on doctors and pilots
Authors: P. A West
Journal: BMJ (2002)

Ethical market in organs Market of organs is unethical under any circumstancesEditor-Although we admire Harris and Erin's commitment to solve the dilemmas posed by a shortage of organs, we strongly disagree not only with their conclusions but also with their assumption-namely, that the selling and buying of human organs can be made ethical. 1 Harris and Erin harness their theory to the laudable commitment to raise donation rates but arrive at the definition of an ethical market by promoting a system that seems to depend only on a restricted group of citizens-those who find the monetary incentives proposed appealing.Firstly, the integrity of the human body should never be subject to trade.Can we truly define this system as ethical because the selling and buying of organs is administered by the state?Secondly, how can a system be called ethical when it implicitly penalises the weakest people and exacerbates discrimination based on census?Will a healthy well-off citizen ever decide to give away part of his or her body for monetary gain?Donation rates might be boosted, but, although both the rich and the poor will continue benefiting from transplantation indiscriminately, organ procurement will be increased only by contributions from poor people.Any commitment towards raising donation rates can be better channelled by using targeted investments, as shown by our experience at the Istituto Mediterraneo per i Trapianti e Terapie ad Alta Specializzazione (ISMETT), a transplant programme recently established in an area with a large shortage in cadaveric organs.Living donation was vigorously pursued from the start of the programme in July 1999.Of 120 transplants performed to date (livers and kidneys), 33% have been from living donors, all family related.At the same time, however, considerable energy has been invested in promoting cadaveric donation.Those efforts have been rewarded by a 314% increase in the donation rate (from 2.8 donors per million in 1999 to 8.9 in 2001).Any financial incentive to organ procurement, even if government regulated, must be avoided as it dangerously undermines human dignity by obscuring the difference between being human and marketing.We recently expressed our concern about the American Medical Association's suggestion of exploring monetary incentives for organ donation, 2 and we are frightened by the enthusiastic support for it by such notable experts as Harris and Erin.
Abstract 18267: Novel Cardioprotective Function of CFTR Chloride Channels Agaisnt Myocardial Hypertrophy and Heart Failure
Authors: Dayue D Duan, Linda Ye
Journal: Circulation (2011)

Background: CFTR is a member of the ATP-binding cassette (ABC) transporters and encodes a PKC- and PKA-activated Cl - channel in the heart. Recent studies found that the expression of the matured CFTR protein in human failing hearts decreased significantly to 52% of CFTR levels in nonfailing controls. A pediatric patient with ΔF508 CFTR mutation died of heart failure (HF) with lethal myocardial lesion but no significant pulmonary fibrosis. The exact functional and clinical significance of CFTR in myocardial hypertrophy (CH) and HF is currently not clear. In this study we will test our hypothesis that CFTR may play a crucial protective role against HF . Methods: Minimally-invasive transverse aorta binding (MTAB) pressure-overload model of CH and HF was applied to CFTR -knockout ( CFTR -/- ) mice and their age- and gender-matched wild-type ( CFTR +/+ ) and heterozygous ( CFTR +/- ) littermates. The functional and histological changes of the hearts subjected to MTAB were examined. Results: MTAB induced a time-dependent development of CH in CFTR +/+ and CFTR -/- mice, as indicated by a significant increase in both end-diastolic and end-systolic left ventricular (LV) mass and wall thickness. During the 9-week period of MTAB, however, the increase in LV mass and LV cavity diameters in the CFTR -/- mice was significantly larger with a much more rapid pace than that in the CFTR +/+ mice, indicating a faster development of dilated cardiomyopathy in the CFTR -/- mice. In sharp contrast to the strong compensation capacity to maintain cardiac function of the CFTR +/+ mice during the 9-week period of MTAB (%FS changed from 62±1.1 to 43±2, a 22.3±2% reduction, n=3) no significant compensation period but a progressively reduced %FS was observed in the CFTR -/- mice. In 9 weeks of MTAB, %FS of the CFTR -/- mice was reduced from 60±1 to 19±3 (n=3, a 69.3±4% reduction, P&lt;0.001 vs CFTR +/+ mice). Conclusion: Targeted disruption of CFTR gene significantly changed the pressure overload-induced remodeling process. The loss of CFTR function may be responsible for the loss of compensation and the faster progression of dilated HF, implicating an important protective role of CFTR in the structural and functional remodeling of the heart in response to pressure overload.