tbuckley/cabot-search huggingface dataset:
Genetic markers of the antigen-specific T cell receptor locus.
Authors: R Epstein, N Roehm, P Marrack, J Kappler, M Davis, S Hedrick, M Cohn
Journal: The Journal of Experimental Medicine (1985)

The restriction enzyme Eco RI reveals DNA cleavage sites that serve to distinguish the gene locus believed to encode the beta subunit of the major histocompatibility complex (MHC)-restricted, antigen-specific receptor of the T cell in BALB/c mice from that of SJL/J mice. A monoclonal antibody, KJ16-133, also distinguishes BALB/c and SJL/J, because it recognizes an allotypic marker present on a cell-surface heterodimer believed to function as the MHC-restricted, antigen-specific T cell receptor. This study has shown that these two markers cosegregate in a set of BALB/c X SJL/J recombinant inbred (RI) mouse strains, permitting the conclusion that they are linked to within 3 centimorgans of each other, and to the kappa locus on chromosome 6. The tight linkage between these independently derived, totally different T cell markers substantially strengthens the argument that they characterize the MHC-restricted antigen-specific receptor of the effector T cell.
Neuromuscular Disease in Primary Hyperparathyroidism
Authors: BERNARD M. PATTEN
Journal: Annals of Internal Medicine (1974)

Fourteen of 16 patients with primary hyperparathyroidism studied prospectively had weakness, easy fatiguability, and atrophy of muscles—particularly of the lower extremities. Electromyograms of these patients showed short-duration, low-amplitude motor unit potentials in some patients and abnormally high amplitude, long-duration polyphasic potentials in others. Motor nerve conduction velocities and distal sensory latencies were normal. The major finding on muscle biopsy was atrophy of both type I and type II muscle fibers, with type II fibers more extensively involved. Typical myopathic features were absent. A low concentration of phosphate in about half the patients was the only cerebrospinal-fluid abnormality noted. No patient had elevated serum glutamicoxalacetic transaminase, creatinine Phosphokinase, or aldolase values. All patients from whom a parathyroid adenoma was removed were significantly better within days to a few weeks of surgery. We conclude that many patients with hyperparathyroidism have treatable neuromuscular disease that is neuropathic in origin.
Abstract P6-07-02: A Systems Analysis of Oscillations in the MAPK Pathway Reveals New Mechanisms of Feed-Forward and Feedback Signaling Control
Authors: H Hu, D Faratian, A Goltsov, J Bown, SP Langdon, DJ. Harrison
Journal: Cancer Research (2010)

Abstract Oscillations occur in diverse areas of cellular biology, from mechanotransduction to circadian control. Their physiological, pathological, and therapeutic significance in breast cancer remains undetermined, and their existence has yet to be described in the key oncogenic signaling pathways. Mathematical modeling lends itself to detailed study of these complex dynamic phenomena. We observed damped oscillations in pERK with approximately 20 minute periodicity in MCF7 breast carcinoma cell lines after stimulation with heregulin or epidermal growth factor (EGF). In order to establish mechanisms by which these oscillations might occur, we used an ordinary differential equation-based mathematical model of MAPK/PI3K signaling to simulate oscillatory behaviour in MAPK signaling. Both modification of feed-forward (HER2 overexpression) and feedback (abrogation of early gene transcription, EGFR phosphorylation by pERK, crosstalk between pAKT and RAF, and binding of pERK with SOS) loops resulted in the emergence of sustained oscillations in phospho-ERK. When these simulations were tested experimentally, MCF7 cells stably transfected with HER2 (MCF7/HER2-18) showed sustained oscillations in pERK when stimulated with heregulin, which were abrogated by inhibition of HER2 heterodimerisation with pertuzumab. Likewise, suppression of transcriptional feedback with cycloheximide resulted in sustained oscillations in pERK of increased amplitude. We have therefore described oscillations in MAPK signalling for the first time in breast cancer cell lines. Since the duration and amplitude of these oscillations is altered both by addition of the HER2 oncogene, and by inhibition of feedback control, the functional consequences of changes in oscillations may have fundamental consequences both in oncogenesis and therapeutic efficacy. Citation Information: Cancer Res 2010;70(24 Suppl):Abstract nr P6-07-02.
Identification and Molecular Cloning of P75/Airm1, a Novel Member of the Sialoadhesin Family That Functions as an Inhibitory Receptor in Human Natural Killer Cells
Authors: Michela Falco, Roberto Biassoni, Cristina Bottino, Massimo Vitale, Simona Sivori, Raffaella Augugliaro, Lorenzo Moretta, Alessandro Moretta
Journal: The Journal of Experimental Medicine (1999)

In this study, by the generation of a specific monoclonal antibody, we identified p75/AIRM1 (for adhesion inhibitory receptor molecule 1), a novel inhibitory receptor that is mostly confined to human natural killer cells. p75/AIRM1 is a 75-kD glycoprotein that, upon sodium pervanadate treatment, becomes tyrosine phosphorylated and associates to src homology 2 domain-bearing protein tyrosine phosphatase (SHP)-1. The p75/AIRM1 gene is located on human chromosome 19 and encodes a novel member of the sialoadhesin family characterized by three immunoglobulin-like extracellular domains (one NH(2)-terminal V-type and two C2-type) and a classical immunoreceptor tyrosine-based inhibitory motif (ITIM) in the cytoplasmic portion. The highest amino acid sequence similarity has been found with the myeloid-specific CD33 molecule and the placental CD33L1 protein. Similar to other sialoadhesin molecules, p75/AIRM1 appears to mediate sialic acid-dependent ligand recognition.
A CASE OF COMA FROM PTOMAIN POISONING SIMULATING ACUTE MENINGITIS.
Authors: ARTHUR D. DUNN
Journal: JAMA (1907)

The following case was deemed worth recording, as it presents unusual and exceptional clinical features which are not mentioned in the text-books or in the literation so far as I have been able to ascertain. It was observed during my service as resident physician in Cook County Hospital, Chicago: <h3>Patient.</h3> —T. D., a well-developed German, aged 23, single, a sailor, was admitted to the hospital in a comatose condition, at 8.30 p. m., June 4, 1903, and was assigned to the service of Dr. W. S. Harpole, with whose permission the case report is published. <h3>History.</h3> —No history was obtainable, except that the man was picked up in an alley by the police. <h3>Examination.</h3> —The coma was of the alcoholic type and he resisted attempts at examination. The body was rigid. There were no signs of violence. Pupils were dilated and equal; no squint. The buccal mucous membrane was normal.
Health Care Reform in Massachusetts — Expanding Coverage, Escalating Costs
Authors: Robert Steinbrook
Journal: New England Journal of Medicine (2008)

After 2 years, health care reforms in Massachusetts have ramped up rapidly, the number of people without health insurance has been substantially reduced, and overall public and political support remains broad. Dr. Robert Steinbrook writes that not all the news is good, however. Jon Kingsdale discusses the recently implemented Massachusetts mandate for universal health insurance coverage and its lessons for the rest of the United States. Dr. Kingsdale is the executive director of the Commonwealth Health Insurance Connector Authority.
Researchers deny any attempt to mislead the public over JAMA article on arthritis drug
Authors: S. Gottlieb
Journal: BMJ (2001)

Researchers at the centre of a row over data presented to JAMA, the journal of the American Medical Association, which showed the results of only the first six months of a trial of a new arthritis drug have defended their actions, following a controversial article in the Washington Post earlier this week (5 August).

The newspaper article accuses researchers of intentionally giving a prominent gastroenterologist incomplete data on the safety of a popular arthritis drug so that he might write a more favourable editorial about their study.

The editorial, published in the 13 September issue of JAMA (2000;284:1297-9) was cowritten by Dr Michael Wolfe, a gastroenterologist …
Quality Measures and Sociodemographic Risk Factors
Authors: Kevin Fiscella, Helen R. Burstin, David R. Nerenz
Journal: JAMA (2014)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Early Psychosomatic Symptom and the Tendency towards Integration
Authors: Renata Gaddini
Journal: Psychotherapy and Psychosomatics (1974)

Each time psychosomatic symptoms appear, something has adversedly affected the use the child is making of the object. We emphasize that the focus of investigation in these cases has to be the interaction between mother and infant, rather than infant or mother, exclusively, because the child's early development is based on interaction. In the study of the organism biology, the mother and child can be considered as one system. That 'system' may safeguard the narcissistic needs of the child and may gradually, through a 'facilitating environment' bring out the narcissism towards the external environment in such a way that it may be invested. It is in this area – in the early 'facilitating' or 'non-facilitating' environment, which in the greatest part is administered by the pediatricians, that we have to look, if we want to produce rational, preventive, and non-interfering interventions in psychosomatic medicine.
790-6 The Incidence and Clinical Relevance of Bundle Branch Block in Patients with Acute Myocardial Infarction Treated with Thrombolytic Agents
Authors: Keith H. Newby, Andrea Natale, Mitchell W. Krucaff, Kenneth G. Morris, Kathleen Trollinger, Akbar Shah, Cindy Green, Nancy Wildermann
Journal: Journal of the American College of Cardiology (1995)
Burkholderia cepacia and Nebulized Albuterol
Authors: Lawrence Scharer
Journal: Annals of Internal Medicine (1996)

Letters15 January 1996Burkholderia cepacia and Nebulized AlbuterolLawrence Scharer, MDLawrence Scharer, MDSt. Luke's Roosevelt Hospital Center; New York, NY 10019Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-124-2-199601150-00019 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:The recent report by Hamill and colleagues [1] on respiratory tract infection associated with nebulized bronchodilator therapy shows that modern equipment does not solve an old problem. Almost 30 years ago, the same observation was made at Bellevue Hospital in New York City [2] and helped to lead manufacturers to develop single-dose vials for this form of therapy.In the Bellevue Hospital outbreak, which was caused by Klebsiella species and led to five deaths, a respiratory therapist was found to be an asymptomatic carrier of the same organism.Perhaps it is time to abolish the use of ...References1. Hamill RJ, Houston ED, Georghiou PR, Wright CE, Koza MA, Cadle RM, et al. An outbreak of Burkholderia (formerly (Pseudomonas) cepacia respiratory tract colonization and infection associated with nebulized albuterol therapy. Ann Intern Med. 1995; 122:762-6. Google Scholar2. Mertz JJ, Scharer L, McClement JH. A hospital outbreak of Klebsiella pneumonia from inhalation therapy with contaminated aerosol solutions. Am Rev Respir Dis. 1967; 95:454-60. Google Scholar Author, Article, and Disclosure InformationAffiliations: St. Luke's Roosevelt Hospital Center; New York, NY 10019 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 15 January 1996Volume 124, Issue 2Page: 274KeywordsBronchodilatorsInhalationKlebsiellaNosocomial infectionsUpper respiratory tract infections Issue Published: 15 January 1996 Copyright & PermissionsCopyright © 1996 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Relation of Systolic Pressure in the Right Ventricle to the Electrocardiogram
Authors: Glen G. Cayler, Patrick Ongley, Alexander S. Nadas
Journal: New England Journal of Medicine (1958)

PULMONARY stenosis with intact ventricular septum raises the systolic pressure in the right ventricle and may lead to cardiac failure. Consequently, all severe lesions of this type, even if unaccompanied by symptoms, require surgical correction. The only accurate method for determining the degree of hypertension is catheterization of the right side of the heart. A previous study from this department1 reported a rather close correlation between the level of systolic pressure in the right ventricle, as recorded at cardiac catheterization, and the height of the R waves in the right precordial leads of the electrocardiogram in patients with pulmonary stenosis . . .
Baseline characteristics and outcomes of patients with heart failure receiving bronchodilators in the CHARM programme
Authors: Nathaniel M. Hawkins, Duolao Wang, Mark C. Petrie, Marc A. Pfeffer, Karl Swedberg, Christopher B. Granger, Salim Yusuf, Scott D. Solomon, Jan Östergren, Eric L. Michelson, Stuart J. Pocock, Aldo P. Maggioni, John J.V. McMurray
Journal: European Journal of Heart Failure (2010)
The measurement of intestinal sounds in man and their relationship to serum 5-hydroxytryptamine
Authors: B. G. Adams
Journal: Gut (1961)

Carbachol and magnesium sulphate were used to increase the motility of the intestine in healthy volunteers. The effect was estimated by recording changes in abdominal sounds. Serum 5-hydroxytryptamine levels were assayed and found to be higher after gastrointestinal stimulation.
Greater Sedentary Hours and Slower Walking Speed Outside the Home Predict Faster Declines in Functioning and Adverse Calf Muscle Changes in Peripheral Arterial Disease
Authors: Mary M. McDermott, Kiang Liu, Luigi Ferrucci, Lu Tian, Jack M. Guralnik, Yihua Liao, Michael H. Criqui
Journal: Journal of the American College of Cardiology (2011)
454 PREDICTIVE FACTORS OF THROMBOCYTOPENIA IN TREATMENT OF CHRONIC HEPATITIS C (CHC) PATIENTS WITH PEGINTERFERON ALFA-2A (40KD) AND RIBAVIRIN
Authors: S. Mauss, A. Schober, T. Lutz, G. Moog, M. Schuchmann, R. Heyne, C. John, W. Schiffelholz, A. Baumgarten, K.-H. Hey, C. Eisenbach, G. Teuber, W. Schmidt, H.-R. Bruch, P. Geyer, U. Alshuth, D. Hueppe
Journal: Journal of Hepatology (2011)
<i>bcl-2</i>and Other Genomic Alterations in the Prognosis of Large-Cell Lymphoma
Authors: Jorge J. Yunis, Mary G. Mayer, Mark A. Arnesen, Dorothee P. Aeppli, Martin M. Oken, Glauco Frizzera
Journal: New England Journal of Medicine (1989)

Approximately half the patients with diffuse or follicular large-cell or mixed large- and small-cell lymphoma enter a prolonged remission or are cured after receiving combined-drug therapy. It has been unclear, however, why the other half do not respond. We evaluated 54 previously untreated patients with diffuse lymphoma and 20 with follicular lymphoma, all of whom had a large-cell component and Stage II through IV disease, subsequently treated with combined chemotherapy. Different recurrent genomic defects were associated with differences in the response to treatment. Among the 54 patients with diffuse lymphoma, all 12 patients with a duplication of chromosome 3p had a complete clinical remission after a median follow-up of 39 months (11 patients survived). In contrast, all seven patients with a duplication of chromosome 2p had a partial response or no response to treatment and a median survival of six months (all died). Among the 20 patients with follicular lymphoma, all 5 patients with duplication 3p or +3 had a complete clinical remission (all survived), and 3 of 4 patients with duplication 2p or +2 had no response or a partial response to treatment and died. Twenty-three patients with B-cell non-immunoblastic lymphoma or follicular lymphoma who had a bcl-2 oncogene rearrangement had a poorer response to therapy (7 of 23 with complete remission) than the patients without bcl-2 rearrangement (21 of 26 with complete remission). We conclude that in large-cell or mixed-cell lymphoma, duplication of chromosome 3p is associated with a relatively good prognosis and duplication of chromosome 2p or bcl-2 oncogene rearrangement is associated with a relatively poor prognosis. Because such multiple recurrent genomic defects are also common in most other types of cancer, they may have general prognostic importance.
Late thrombolytic therapy preserves left ventricular function in patients with collateralized total coronary occlusion: Primary end point findings of the second mount sinai-new york university reperfusion trial
Authors: K.Peter Rentrop, Frederick Feit, Warren Sherman, Peter Stecy, Susan Hosat, Marc Cohen, Mariano Rey, John Ambrose, Mark Nachamie, William Schwartz, William Cole, Robert Perdoncin, John C. Thornton
Journal: Journal of the American College of Cardiology (1989)
A Mild Form of Adult-Onset Opsoclonus-Myoclonus Syndrome Associated With Antiglutamate Receptor Antibodies—Reply
Authors: Andrew McKeon, Sean Pittock
Journal: JAMA Neurology (2013)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Neurology HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Neurology journal
A comparative study of benign chronic bullous dermatosis of childhood and linear IgA dermatosis of adults
Authors: F. Wojnarowska, R.A. Marsden, P.H. McKee, M.M. Black
Journal: British Journal of Dermatology (1985)

Benign chronic bullous dermatosis of childhood (BCBDC) is an apparently self‐limiting vesiculo‐bullous disease showing linear IgA deposits in the basement membrane zone and which seems to occur exclusively in children. Its relationship to linear IgA dermatosis of adults (LAD) is uncertain and for this reason we studied 28 patients with BCBDC (onset before puberty) and compared them with 18 patients with LAD (onset after puberty). No significant clinical, HLA, histological or immunopathological differences were found between the two disorders. Surprisingly, nine patients in each group had conjunctival scarring which in some produced a cicatricial pemphigoid‐like appearance and in one case of BCBDC resulted in blindness. Remissions with loss of IgA from the skin occurred in patients from both groups. However, the disease duration varied considerably (BCBDC 2–28 and LAD 1–40 years) with six BCBDC patients having had their disease for over 10 years and five of them passing puberty. All patients (six BCBDC, eight LAD) studied by immuno‐electronmicroscopy showed localization of IgA beneath the basal lamina. Direct and indirect immunofluorescence studies using suction blisters also gave similar results in both groups. As a result of this study many of our former views on BCBDC have been revised and we now believe that both BCBDC and LAD are manifestations of the same disease.
Abstract 381: Light-absorbing nanoparticles induce cell death in esophageal cancer cells
Authors: Yan Li, Andre M. Gobin, Gerald W Dryden, Deyi Xiao, Guandong Zhang, Robert C. Martin
Journal: Cancer Research (2011)

Abstract Background Light-absorbing nanoparticles that are nontoxic to biological tissue possess the potential for targeted killing of cancer cells while causing minimal collateral damage to adjacent healthy tissue. Gold nanoparticles with near infrared (nIR)-absorbing light properties are ideal for this application. Aim: This study is to investigate the photo-thermal ablation effect of nIR-absorbing gold nanoparticles coated with a natural polymer (chitosan) on esophageal cancer cells as well as benign cells. Methods: Three esophageal cell lines used are human squamous esophageal epithelium cell line (Het-1A), Barrett's epithelium cell line (BAR-T), and the esophageal adenocarcinoma cell line (OE-19). Furthermore, the uptake of gold nanoparticles in the benign esophageal tissue and the response to laser exposure was also valuated in a rat esophagoduodenal anastomosis (EDA) model. Three cell lines were treated with gold nanoparticles (OD=25) then exposed to laser at a wavelength of 817 nm and power density of 3W/cm2 for 3 min. The esophageal mucosa of rats was sprayed with gold nanoparticles 24 hours befor laser application. After treatment, the rats were exposed to laser at a wavelength of 817 nm and power density of 4.15W/cm2 for 3 min. The loading of gold nanoparticles was detected by silver staining. Results: The most OE-19 cells loaded with gold nanoparticles and were completely ablated after nIR light exposure. However, most Het-1A cells and BAR-T cells didn't load on any gold nanoparticles, and they remained viable after nIR light exposure. Normal esophageal epithelium and Barrett's mateplastic epithelium show low affinity to gold nanoparticles, however, the focal region with more loaded gold nanoparticles was ablated after nIR light exposure. Conclusion: 1) Chitosan coated gold nanoparticles undergo targeted uptake by OE-19 cells, with a much higher affinity compared to benign cells. 2) Photo-thermo-ablation by nIR light exposure causes a directed cancer cell-killing effect based on preferential gold nanoparticle uptake. 3) Further study is ongoing to investigate methods of enhancing peak uptake of gold nanoparticles in the EDA rat model, to provide an optimal model for laser ablation of esophageal cancer. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 102nd Annual Meeting of the American Association for Cancer Research; 2011 Apr 2-6; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2011;71(8 Suppl):Abstract nr 381. doi:10.1158/1538-7445.AM2011-381