Human Herpesviruses at Sixes, Sevens, and More
Authors: Caroline Breese Hall
Journal: Annals of Internal Medicine (1997)

Editorials15 September 1997Human Herpesviruses at Sixes, Sevens, and MoreCaroline Breese Hall, MDCaroline Breese Hall, MDUniversity of Rochester School of Medicine and Dentistry; Rochester, NY 14642Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-127-6-199709150-00010 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail In the past decade, the family circle of human herpesviruses (HHVs) has expanded to include three new numbers: HHV-6, −7,and −8.Although each was initially discovered in adults, their reputation, relevance, and renitence begin in infancy.Techniques developed to study HIV infection revealed the existence of HHV-6. Initially found in the lymphocytes of patients with AIDS and lymphoproliferative diseases, this novel virus bore a familial resemblance to the herpesviruses and was adopted as their sixth member [1]. Composed of a large double-stranded DNA, DNA polymerase (but not thymidine kinase), and several important glycoproteins, HHV-6 can infect many types of cell but, ...References1. Salahuddin SZ, Ablashi DV, Markham PD, Josephs SF, Sturzenegger S, Kaplan M, et al. Isolation of a new virus, HBLV, in patients with lymphoproliferative disorders. Science. 1986; 234:596-601. Google Scholar2. Dewhurst S. Newly discovered human herpesviruses (HHV-6, HHV-7). Current Opinion in Infectious Diseases. 1994; 7:238-45. Google Scholar3. Hall CB, Long CE, Schnabel KC, Caserta MT, McIntyre KM, Costanzo MA, et al. Human herpesvirus-6 infection in children. A prospective study of complications and reactivation. N Engl J Med. 1994; 331:432-8. Google Scholar4. Yamanishi K, Okuno T, Shiraki K, Takahashi M, Kondo T, Asano Y, et al. Identification of human herpesvirus-6 as a causal agent for exanthem subitum. Lancet. 1988; 1:1065-7. Google Scholar5. 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Human herpesvirus-8 in AIDS-related and unrelated lymphomas. AIDS. 1996; 10:545-6. Google Scholar Author, Article, and Disclosure InformationAffiliations: University of Rochester School of Medicine and Dentistry; Rochester, NY 14642Grant Support: In part by grant RO1 A 133020-02 from the National Institutes of Allergy and Infectious Diseases. 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