tbuckley/cabot-search huggingface dataset:
Percutaneous electrohydraulic lithotripsy of retained bile duct calculus.
Authors: S R Ebbs, D E Beckly, J C Hammonds, C Teasdale
Journal: BMJ (1986)

Une observation: fragmentation reussie d'un calcul volumineux residuel 8 semaines apres chirurgie. Les endoscopes et le generateur electrique sont introduits a travers le tube de drainage
Review of tennis elbow was biased
Authors: Jan M Bjordal, Jan Hendrik Demmink
Journal: BMJ (2004)

Research on preventing road traffic injuries in developing countries is neededEditor-The dedication of the World Health Organization's World Health Day 2004 to road safety is recognition of the global threat of road traffic injuries.Increasing population size, vehicle ownership, road infrastructure, and transnational transportation have created a substantial public health burden.However, little epidemiological research has been conducted into preventing road traffic injuries in developing countries.Currently global research and development funding per disability adjusted life year for HIV, asthma, and blindness are $26.2,$10.8, and $5.4, respectively, while only $0.40 for road traffic injuries. 1 Epidemiological studies of successful interventions preventing road traffic injuries have been conducted in developed countries. 2But to assume the same effectiveness in developing countries is inappropriate because of behavioural, vehicular, and environmental differences.A pooled analysis of street lighting intervention data from developed countries shows a protective effect, 3 particularly in pedestrian injury (relative risk 0.56), the most common road traffic injuries in developing countries.Annually, 1.2 million deaths are attributed to road traffic crashes, 85% occurring in developing countries. 4If an intervention such as street lighting could reduce deaths by as much as 30%, there is a potential to save thousands of lives.Various international aid agencies are investing in road infrastructure development.These initiatives could be coupled with the need to develop concrete epidemiological data.Innovative strategies, such as step wedge study design, 5 could lead to the evolution of an evidence based public health approach to this problem.
Fluroxene Anesthesia for Pheochromocytoma Removal
Authors: Thomas A. Joas
Journal: JAMA (1969)

In 1951 Apgar and Papper stated, "There appears to be no agreement in the literature on the most desirable means of anesthetic management for pheochromocytoma excision."<sup>1</sup>This statement applies equally well today, even with better understanding of the autonomic nervous system<sup>2</sup>and the concept of alpha- and beta-adrenergic receptors and blockers.<sup>3</sup>Concomitant with development of adrenergic pharmacology has been the introduction of the halogenated anesthetic agents, halothane, methoxyflurane, and fluroxene. The literature is replete with reports of pheochromocytoma removal utilizing alpha- and beta-adrenergic blockade in conjunction with many general anesthetic agents.<sup>4-6</sup>Halothane is a popular general anesthetic agent and has both advocates<sup>4</sup>and opponents<sup>7</sup>concerning its use alone or with other drugs. Several reports have described the use of methoxyflurane for the removal of pheochromocytoma,<sup>8,9</sup>but, to our knowledge, there is only one published instance of fluroxene anesthesia for pheochromocytoma removal.<sup>10</sup> We have
Tenascin-C as Predictor of Left Ventricular Remodeling and Mortality in Patients with Dilated Cardiomyopathy
Authors: Bahadır Şarlı, Topsakal Ramazan, Esma G Kaya, Mahmut Akpek, Yat Yin Lam, Mehmet G Kaya
Journal: Journal of the American College of Cardiology (2013)
One-Year Outcomes of Photodynamic Therapy in Age-Related Macular Degeneration and Polypoidal Choroidal Vasculopathy in Japanese Patients
Authors: Fumi Gomi, Masahito Ohji, Kaori Sayanagi, Miki Sawa, Hirokazu Sakaguchi, Yusuke Oshima, Yasushi Ikuno, Yasuo Tano
Journal: Ophthalmology (2007)
A British Medical Association Lecture ON SOME PROBLEMS OF THYROID DISEASE: Delivered before the Ulster Branch on April 30th
Authors: R. McCarrison
Journal: BMJ (1925)

THE problems to which I desire to direct attentioni ime- late (1) to certaini causes of thyroid disorder; (2) to the influence of iodine in preveniting-either tlhyroid livyperplasia or undue accumulation of colloid iimaterial in the gland; and (3) to the tvpes of simple goit-re with whiclh we have to deal wlhen employinig iodine as a prophylactic agent.CAUSES OF THYROID DISORDER.An essential function of the thyroid gland is the maniu- facture, and supply to the body tissues, of a secretion containinig certain active principles or hormones.This endocrine activity is generally believed to constitute the gland's sole function; but it may be doubted wlhether it lias not some other part to play in the mu-etabolic cycle, and whether the administration of the whole gland substanice, or of its extracts, provides a complete substitute for the gland itself.Thyroxin, whicli contains 65 per cent. of iodine, is regarded as the chief, if niot the only, active principle of the gland; but it has not yet been defilnitely proven that thyroxin is produced as suclh in rivo.Never- theless, most, if not all, of the thyroid gland's activ-ities are exhibitedl by this substanice.Assumiiing that tlhyroxin
Correlation between manometric and pH tests for gastro-oesophageal reflux.
Authors: C Stanciu, R C Hoare, J R Bennett
Journal: Gut (1977)

A series of tests, including gastro-oesophageal sphincter pressure measurement, short-term pH tests, and 15-hour overnight oesophageal pH recording were applied to 42 normal subjects and 214 patients with typical reflux symptoms. The results were compared by multivariate discriminant analysis. Sphincter pressure measurements misclassified 32%, stressed provocative manoeuvres 14-5%, and the best single discriminator from the overnight pH study was time below pH 5, which misclassified 13%. However, a combination of the number of reflux episodes in 15 hours with their mean duration reduced misclassification to 8-8%. Using this function, a boundary between normal and reflux can be drawn, and the degree of abnormality can be expressed visually as well as numerically.
Regulation of Mitochondrial [NADH] by Cytosolic [Ca <sup>2+</sup> ] and Work in Trabeculae From Hypertrophic and Normal Rat Hearts
Authors: Rolf Brandes, Lars S. Maier, Donald M. Bers
Journal: Circulation Research (1998)

Pressure overload hypertrophy has previously been shown to reduce contractility but paradoxically to increase O2 consumption rates at a given force. Because O2 consumption rates are related to mitochondrial [NADH] ([NADH]m), we tested the hypothesis that with hypertrophy, control of [NADH]m may be altered. Left ventricular trabeculae were isolated from banded and control rat hearts, and fluorescence spectroscopy was used to monitor [NADH]m and cytosolic [Ca2+] ([Ca2+]c). The hearts from banded rats developed hypertrophy (heart-to-body weight ratio increased from 4.1+/-0.1 to 4.9+/-0.1 mg/g) and hypertension (systolic arterial pressure increased from 117+/-4 to 175+/-5 mm Hg). Muscle workload was increased by stepwise increases in pacing frequency (up to 2 Hz). After increased work, [NADH]m fell and then slowly recovered toward control levels. When work was decreased, [NADH]m overshot control values and then slowly returned. The Ca2+-independent initial fall was larger for trabeculae from rats with hypertrophied hearts than from control rats (eg, 17+/-2% versus 11+/-1% when work was increased by increasing the frequency from 0.25 to 1 Hz). At 1 Hz, average [Ca2+]c was approximately 280 nmol/L, and the Ca2+-dependent [NADH]m recovery was larger for trabeculae from rats with hypertrophied hearts (17+/-4% versus 10+/-2%) despite similar average [Ca2+]c. At steady state after Ca2+-dependent recovery, there was no difference in [NADH]m (fall of 1+/-2% versus 1+/-1%). Furthermore, the Ca2+-dependent overshoot was larger for trabeculae from hypertrophied than from control hearts (increase of 14+/-2% versus 9+/-2% when frequency was decreased from 1 to 0.25 Hz). We conclude that (1) there is initially a larger imbalance in NADH production versus consumption rate in hypertrophy (because NADH fell more) and (2) the Ca2+-dependent recovery mechanism is enhanced in hypertrophy (because NADH recovered and overshot more), thus compensating for the larger imbalance.
Role of heparin-binding epidermal growth factor–like growth factor as a hepatotrophic factor in rat liver regeneration after partial hepatectomy
Authors: Shinichi Kiso, Sumio Kawata, Shinji Tamura, Shigeki Higashiyama, Nobuyuki Ito, Hirofumi Tsushima, Naoyuki Taniguchi, Yuji Matsuzawa
Journal: Hepatology (1995)

Several growth factors including hepatocyte growth factor (HGF) have been implicated in the regulation of liver regeneration. Recently, we reported that heparinbinding epidermal growth factor (EGF)-like growth factor (HB-EGF) has hepatotrophic effects in vitro. We investigated the role of HB-EGF as a hepatotrophic factor in regenerating rat liver after 70% partial hepatectomy. The level of HB-EGF messenger RNA (mRNA) in regenerating rat liver increased 1.5 hours after partial hepatectomy and reached a maximum (about sevenfold over normal) at 6 hours. In contrast, hepatic HGF mRNA levels increased at 12 hours and achieved maximal expression at 24 hours. HB-EGF protein expression increased about 2.8-fold over normal at 10 hours after partial hepatectomy. The number of EGF receptors, to which HB-EGF binds, decreased 6 hours after partial hepatectomy. HB-EGF mRNA levels increased in nonparenchymal cells (NPCs) at 6 hours after partial hepatectomy but not in hepatocytes. Using the reverse transcription-polymerase chain reaction (RT-PCR), HB-EGF gene expression was increased predominantly in Kupffer cells and sinusoidal endothelial cells but not in lipocytes and hepatocytes. These results indicated that HB-EGF may be an important growth factor, produced in an earlier phase rather than HGF, in the regenerating liver after partial hepatectomy by a paracrine mechanism. (Hepatology 1995; 22:1584–1590).
MR Imaging of the Body
Authors: Daniel Cornfeld
Journal: JAMA (2010)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Drug-induced Pulmonary Hypertension?
Authors: F. Follath, F. Burkart, W. Schweizer
Journal: BMJ (1971)

Of 40 patients with obstructive pulmonary hypertension studied in Basle, Switzerland, during the period 1966-68, 32 had been taking an anorectic drug, aminorex fumarate. Rapidly progressing exertional dyspnoea, central chest pain, and syncope on effort were characteristic features. The absence of the usual causes of pulmonary vascular disease seems to suggest the possibility of drug-induced pulmonary hypertension. Further studies are necessary, however, to clarify the role of aminorex fumarate in this condition.
Expression of Class III Beta-Tubulin Correlates with Unfavorable Survival Outcome in Patients with Resected Non-small Cell Lung Cancer
Authors: Youngil Koh, Bogun Jang, Sae-Won Han, Tae-Min Kim, Do-Youn Oh, Se-Hoon Lee, Chang Hyun Kang, Dong-Wan Kim, Seock-Ah Im, Doo Hyun Chung, Young Tae Kim, Tae-You Kim, Young-Whan Kim, Joo Hyun Kim, Dae Seog Heo, Yung-Jue Bang
Journal: Journal of Thoracic Oncology (2010)
Scintigraphic Localization of Recurrent Anastomotic Site Bleeding in the Gastrointestinal Tract
Authors: SANJEEV BAGGA, SHIV M. GUPTA, WILLIAM JOHNS
Journal: Clinical Nuclear Medicine (1996)

Scanning with Tc-99m labeled RBC was performed in two patients with recurrent postoperative gastrointestinal bleeding after partial colonic resection. Imaging correctly identified the source of bleeding at the anastomotic site in the large bowel, effectively contributing in the patient's treatment planning. Radionuclide scintigraphy provides a simple, noninvasive modality to diagnose and manage difficult clinical situations such as postoperative bleeding.
Anti-CTLA4 Antibody–Induced Lupus Nephritis
Authors: Fouad Fadel, Khalil El Karoui, Bertrand Knebelmann
Journal: New England Journal of Medicine (2009)

To the Editor: A 64-year-old man with a history of metastatic melanoma was admitted to our hospital for the nephrotic syndrome in 2006. In 2005, subcutaneous metastases had been diagnosed, which were resistant to conventional chemotherapy. The patient then received monotherapy with ipilimumab (investigational agent, Bristol-Myers Squibb), a monoclonal antibody against cytotoxic T-lymphocyte–associated antigen 4 (CTLA4), at a dose of 3 mg per kilogram of body weight given intravenously every 3 weeks. Proteinuria was not present before the protocol was initiated, and the nephrotic syndrome was diagnosed after two injections. Physical examination showed only a 3-cm inguinal lymphadenopathy on the . . .
Contributions of intracellular and extracellular Ca2+ pools to activation of myosin phosphorylation and stress in swine carotid media.
Authors: P H Ratz, R A Murphy
Journal: Circulation Research (1987)

Contractile agonists can mobilize Ca2+ from both intracellular and extracellular stores in smooth muscle. This study addresses the role of Ca2+ mobilization as it relates to the complex manner by which Ca2+ regulates the contractile system in smooth muscle. In swine carotid media, both histamine and phenylephrine produced initial rapid increases in myosin phosphorylation and stress. Stress was sustained for the duration of the stimulus while myosin phosphorylation slowly declined to steady-state levels. Removal of extracellular Ca2+ or elimination of cellular Ca2+ influx did not dramatically reduce the initial rapid increase in myosin phosphorylation produced by either agonist but reduced steady-state levels of myosin phosphorylation to basal values. Initial rapid increases in stress were seen, but stress was not maintained. Following depletion of Ca2+ from sarcoplasmic reticulum, muscle activation by Ca2+ influx in the presence of phenylephrine occurred without an initial transient in myosin phosphorylation, and stress developed slowly. Steady-state levels of myosin phosphorylation and stress were not different from control values. Similar results were obtained with histamine, although a small transient in myosin phosphorylation was also seen. These results are consistent with the hypothesis that the role of the sarcoplasmic reticulum in vascular smooth muscle is to provide high myoplasmic Ca2+ concentrations causing extensive myosin phosphorylation and rapid crossbridge cycling leading to rapid stress development. In the presence of extracellular Ca2+, control levels of agonist-induced steady-state stress and myosin phosphorylation could be produced without an initial phosphorylation transient when intracellular Ca2+ pools were depleted, suggesting that the sarcoplasmic reticulum is not required for the regulation of steady-state myoplasmic [Ca2+] during "latch".
Diseases of Cellular Immunity
Authors: E. RICHARD STIEHM
Journal: Annals of Internal Medicine (1972)

Cellular immune reactions are mediated by lymphocytes and their products, the cellular mediators. Although it is convenient to consider cellular immunity and antibody immunity as separate, many interrelationships have been found both in the normal immune response and in such disorders as infections, transplant rejections, autoimmunity, and immunodeficiency. Difficulty in assessing cellular immunity has hampered understanding of its full contribution. Diagnosis of cellular immunodeficiency is aided by total peripheral counts, skin tests, in vitro lymphocyte responses to phytohemagglutinin, allogeneic cells and antigens and mediator assays, particularly migratory inhibiting factor assays. Such procedures are needed for exact diagnosis and appropriate specific therapy, including transfer factor from immune lymphocytes, neonatal thymus transplants, and bone marrow transplants. Transfer factor is especially valuable in Wiskott-Aldrich syndrome and mucocutaneous candidiasis, thymus transplant in thymic hypoplasia (DiGeorge syndrome), and bone marrow transplant in combined immunodeficiency (Swiss agammaglobulinemia) when an HL-A identical sibling is available as donor.
LA Emptying Fraction Improves Diagnosis of Paroxysmal AF After Cryptogenic Ischemic Stroke: Results From the SURPRISE Study
Authors: Tor Biering-Sørensen, Louisa M. Christensen, Derk W. Krieger, Rasmus Mogelvang, Jan Skov Jensen, Søren Højberg, Nis Høst, Finn Michael Karlsen, Hanne Christensen
Journal: JACC. Cardiovascular imaging (2014)
INJURIES IN GERMAN CLUB SPORTS – 1987 TO 2012
Authors: T Henke, P Luig, D Schulz
Journal: British Journal of Sports Medicine (2014)

Background In Germany 26 million citizens, almost 30% of the total population, are registered in sports clubs. Nowadays, sport as part of a healthy and physically active lifestyle is virtually accepted as medicine against widespread diseases. The positive effects of sports on wellbeing and health are undoubted. However, about 2 million sports injuries occur annually. 700,000 of these result from club sports. Objective To describe and analyse the epidemiology of sports injuries and to identify focal areas for sports injury prevention programmes on the basis of 25 years of injury surveillance data for German club sports. Design Retrospective longitudinal study with questionnaire-based injury registration. Since 1987 a database of more than 200 000 sports injuries has been established. Athletes that report a sports accident to the ARAG sports insurance are asked to complete an anonymized questionnaire on the accident, injury, treatment and sports behaviour. Setting Non-professional club sports participants. Results 75% of the injuries are registered in soccer, handball, basketball and volleyball, although only 30% of all sports club members are organized in these sports. The number of women's soccer injuries has risen from 7% to 15%. Ankle injuries have decreased from 30% to 19%, whereas the rate of knee injuries has increased slightly from 17% to 21%. Days of disability have dropped steadily since the 1990s, whereas inpatient hospital days have doubled from 5 to 10 days. The share of injuries that need surgery increased from 30% to 40%. Injuries to the knee, lower leg and upper arm have the highest surgery rate, indicating more serious injuries here. Conclusion Team sports are a clear focal area for injury prevention, in particular as the number of female participants in these sports has dramatically increased since 1987. For tailoring the prevention measures more specific to the target groups the following differentiation of prevention approaches is useful: Training &amp; Physical Preparation, Technical &amp; Political Approaches, Equipment &amp; Facilities, Medical &amp; Non-medical Support.
Prevention of rejection of allogeneic endothelial cells in a biohybrid lung by silencing HLA-class I expression
Authors: Bettina Wiegmann, Constança Figueiredo, Christiane Gras, Michael Pflaum, Sabrina Schmeckebier, Sotirios Korossis, Axel Haverich, Rainer Blasczyk
Journal: Biomaterials (2014)
Validity of Messenger RNA Expression Analyses of Human Saliva
Authors: Shalini V. Kumar, Gregory J. Hurteau, Simon D. Spivack
Journal: Clinical Cancer Research (2006)

Abstract Purpose: The origins of expression microarray and reverse transcription-PCR (RT-PCR) signals in human saliva were evaluated. Experimental Design: The “RNA” extracts from human saliva samples were treated with vehicle, DNase, or RNase. Two-step amplification and hybridization to Affymetrix 133A cDNA microarrays were then done. Confirmatory RT-PCR experiments used conventionally designed PCR primer pairs for the reference housekeeper transcripts encoding 36B4, β-actin, and glyceraldehyde-3-phosphate dehydrogenase (GAPDH) mRNA sequences, which are known to be homologous to genomic DNA pseudogene sequences. Negative controls included the omission of reverse transcriptase (“no-RT”) to detect any DNA-derived signal. Finally, an RNA-specific RT-PCR strategy eliminated confounding signals from contaminating genomic DNA. Results: Microarray experiments revealed that untreated, DNase-treated, and RNase-treated “RNA” extracts from saliva all yielded negligible overall signals. Specific microarray signals for 36B4, β-actin, and GAPDH were low, and were unaffected by RNase. Real-time quantitative RT-PCR reactions using conventional, non–RNA-specific primers on saliva samples yielded PCR products for 36B4, β-actin, and GAPDH; DNase-treated saliva samples did not yield a PCR product, and the “no-RT” and “+RT” conditions yielded similar amounts of PCR product. The RNA-specific RT-PCR strategy, across all conditions, yielded no PCR product from saliva. Conclusions: The combination of (a) a minimal microarray signal, which was unaffected by RNase treatment, (b) the presence of a conventional RT-PCR housekeeper product in both RNase-treated and no-RT saliva samples, (c) the absence of a conventional RT-PCR housekeeper product in DNase-treated conditions, and (d) the absence of a RNA-specific RT-PCR product shows that any microarray or RT-PCR signal in the saliva must arise from genomic DNA, not RNA. Thus, saliva extracts do not support mRNA expression studies.