THE HEMOPOIETIC LIVER PRINCIPLE
Authors: G. E. Wakerlin
Journal: Annals of Internal Medicine (1937)

Article1 July 1937THE HEMOPOIETIC LIVER PRINCIPLEG. E. WAKERLIN, M.D., Ph.D., F.A.C.P.G. E. WAKERLIN, M.D., Ph.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-11-1-31 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe hemopoietic liver principle is also known as the anti-pernicious anemia principle and the erythrogenic liver principle. As you are aware, the interaction in the gastrointestinal tract of an as yet unidentified constituent of the gastric juice, called the "intrinsic factor," with some dietary component associated with protein, known as the "extrinsic factor," forms a third substance which is absorbed via the portal circulation and stored in the liver where it is very likely further elaborated. This substance, the hemopoietic liver principle, is then released to the bone marrow where it brings about the normal maturation of the red blood...References1. MINOTMURPHY GRW: Treatment of pernicious anemia by a special diet, Jr. Am. Med. Assoc., 1926, lxxxvii, 470. CrossrefGoogle Scholar2. COHNMINOTFULTONULRICHSSARGENTWEAREMURPHY EJGRJFHFFCJHWP: The nature of the material in liver effective in pernicious anemia. I, Proc. Am. Soc. Biol. Chem., Jr. Biol. Chem., 1927, lxxiv, lxix. Google Scholar3. COHNMINOTALLESSALTER EJGRGAWT: The nature of the material effective in pernicious anemia. II, Jr. Biol. Chem., 1928, lxxvii, 325. CrossrefGoogle Scholar4. GÄNSSLEN M: Ein hochwirksamer injizierbarer Leberextrakt, Klin. Wchnschr., 1930, ix, 2099. CrossrefGoogle Scholar5. COHNMCMEEKINMINOT EJTLGR: The nature of the material effective in pernicious anemia. IV, Proc. Am. Soc. Biol. Chem., Jr. Biol. Chem., 1930, lxxxvii, xlix. Google Scholar6. 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Author, Article, and Disclosure InformationAffiliations: Louisville, Kentucky*Presented at the St. Louis meeting of the American College of Physicians, April 22, 1937.From the Department of Physiology and Pharmacology, University of Louisville School of Medicine. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byChemistry of Anti-Pernicious Anemia Substances of Liver 1 July 1937Volume 11, Issue 1Page: 31-38KeywordsAnemiaBloodBone marrowGastrointestinal tractLiverPharmacology ePublished: 1 December 2008 Issue Published: 1 July 1937 PDF downloadLoading ...