MYCELIAL FORMS OF COCCIDIOIDES IMMITIS IN SPUTUM AND TISSUES OF THE HUMAN HOST
Authors: M J FIESE, S CHEU, R H SORENSEN
Journal: Annals of Internal Medicine (1955)

Article1 August 1955MYCELIAL FORMS OF COCCIDIOIDES IMMITIS IN SPUTUM AND TISSUES OF THE HUMAN HOSTMARSHALL J. FIESE, M.D., STEPHEN CHEU, M.D., ROYAL H. SORENSEN, B.S.MARSHALL J. FIESE, M.D.Search for more papers by this author, STEPHEN CHEU, M.D.Search for more papers by this author, ROYAL H. SORENSEN, B.S.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-43-2-255 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptFor half a century it has been known that Coccidioides immitis ordinarily exists in two distinct phases, the saprophytic and the parasitic, the former occurring in external nature and culture media, and the latter, in animal tissues. The biphasic life cycle of the fungus was first outlined by Ophüls,1 and was more extensively delineated by Baker, Mrak and Smith.2The usual life cycles of the fungus are as follows:Parasitic Cycle:The injected or inhaled arthrospore or chlamydospore becomes rounded and shows the doubly refractile walls of the spherule or sporangium. Its protoplasm divides by cleavage planes to form endospores,...Bibliography1. Ophüls W: Further observations on a pathogenic mould formerly described as a protozoan (Coccidioides immitis, Coccidioides pyogenes), J. Exper. Med. 6: 443, 1905. CrossrefMedlineGoogle Scholar2. BakerMrakSmith EEEMCE: The morphology, taxonomy, and distribution of Coccidioides immitis Rixford and Gilchrist 1896, Farlowia 1: 199, 1943. Google Scholar3. MacNealTaylor WJRM: Coccidioides immitis and coccidioidal granuloma, J. Med. Research 30: 261, 1914. Google Scholar4. Lack AR: Spherule formation and endosporulation of the fungus coccidioides in vitro , Proc. Soc. Exper. Biol. and Med. 38: 907, 1938. CrossrefGoogle Scholar5. BakerMrak EEEM: Spherule formation in culture by Coccidioides immitis, Rixford and Gilchrist, Am. J. Trop. Med. 21: 589, 1941. CrossrefGoogle Scholar6. Burke RC: In vitro cultivation of the parasitic phase of Coccidioides immitis , Proc. Soc. Exper. Biol. and Med. 76: 332, 1951. CrossrefMedlineGoogle Scholar7. LubarskyPlunkett ROA (a) : In vitro production of spherule phase of Coccidioides immitis ; read before the Society of American Bacteriologists, Northern California, Hawaii, and Southern California Branches, at the 121st Annual Meeting of the American Association for the Advancement of Science, December 27, 1954, University of California, Berkeley. (b) Conant, N. F., and Vogel, R. A.: The parasitic growth phase of Coccidioides immitis in culture, Mycologia 46: 157, 1954. Google Scholar8. DennisHansen JLAE: Coccidioidomycosis in children, Pediatrics 14: 481 (Nov.) 1954. MedlineGoogle Scholar9. SmithBeardSaito CERRMT: Pathogenesis of coccidioidomycosis with special reference to pulmonary cavitation, Ann. Int. Med. 29: 623, 1948. LinkGoogle Scholar10. ForbusBestebreurtje WDAM: Coccidioidomycosis; a study of ninety-five cases of the disseminated type with special reference to the pathogenesis of the disease, Mil. Surgeon 99: 653, 1946. CrossrefMedlineGoogle Scholar11. Barnes HR: (Discussion) Pulmonary coccidioidomycosis, Dis. of Chest 12: 371, 1946. CrossrefMedlineGoogle Scholar12. GreerCrow SJJB: The surgical lesions of pulmonary coccidioidomycosis, Dis. of Chest 16: 336, 1949. CrossrefMedlineGoogle Scholar13. GreerForseeMahon SJJHHW: The surgical management of pulmonary coccidioidomycosis in focalized lesions, J. Thoracic Surg. 18: 591, 1949. CrossrefGoogle Scholar14. Raine F: (Discussion) The surgical management of pulmonary coccidioidomycosis in focalized lesions, J. Thoracic Surg. 18: 591, 1949. CrossrefGoogle Scholar15. WeiselOwen WGC: Pulmonary resection for coccidioidomycosis, J. Thoracic Surg. 18: 674, 1949. CrossrefGoogle Scholar16. RosenthalElmore SRFH: Studies on the contagiousness of coccidioidomycosis. II. The fate of spherules in sputum exposed out of doors, Am. Rev. Tuberc. 61: 95, 1950. MedlineGoogle Scholar17. Smith CE: Personal communication to the author. Google Scholar18. Guilfoil PH: Surgical therapy for pulmonary coccidioidomycosis, Am. Surgeon 19: 975, 1953. MedlineGoogle Scholar19. SeaburyPeabodyLiberman JHJWMJ: The usefulness of the Hotchkiss-McManus stain for the diagnosis of deep mycoses, Dis. of Chest 25: 1 (Jan.) 1954. MedlineGoogle Scholar20. Puckett TF: Hyphae of Coccidioides immitis in tissues of the human host, Am. Rev. Tuberc. 70: 320 (Aug.) 1954. MedlineGoogle Scholar21. JoressBushueff MHBP: Pulmonary coccidioidomycosis; clinical and roentgenological observations in residual lesions, Dis. of Chest 22: 55, 1952. CrossrefMedlineGoogle Scholar22. KligmanMesconDeLamater AMHED: The Hotchkiss-McManus stain for the histopathologic diagnosis of fungus diseases, Am. J. Clin. Path. 21: 86, 1951. CrossrefMedlineGoogle Scholar23. Gomes S: An easy and rapid method for staining treponemas, Foreign Letters, J. A. M. A. 148: 135, 1952. Google Scholar24. Emura ET: Rapid and easy method for staining spirochetes with fountain pen ink, Arch. Dermat. and Syph. 67: 210, 1953. CrossrefGoogle Scholar25. Cohen MM: A simple procedure for staining tinea versicolor (M. furfur) with fountain pen ink, J. Invest. Dermat. 22: 9 (Jan.) 1954. CrossrefMedlineGoogle Scholar26. SorensenCheuFiese RHSMJ: A simple procedure for staining the mycelia and spherules of Coccidioides immitis with fountain pen ink, in preparation. Google Scholar27. GeorgAjelloGordon LKLMA: A selective medium for the isolation of Coccidioides immitis , Science 114: 387, 1951. CrossrefMedlineGoogle Scholar28. Winn WA: Pulmonary mycoses: coccidioidomycosis and pulmonary cavitation; a study of ninety-two cases, Arch. Int. Med. 87: 541, 1951. CrossrefGoogle Scholar29. RosenthalRoutien SRJB: Contagiousness of coccidioidomycosis; an experimental study, Arch. Int. Med. 80: 343, 1947. CrossrefGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Fresno, California*Received for publication January 29, 1955.From the Medical Service and the Laboratory Service, Veterans Administration Hospital, Fresno, California. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byCharacterization of the Growth and Morphology of a BSL-2 Coccidioides posadasii Strain That Persists in the Parasitic Life Cycle at Ambient CO2Early Events in CoccidioidomycosisArthroconidia in lung tissue: an unusual histopathological finding in pulmonary coccidioidomycosisEndocarditis Caused by Coccidioides SpeciesArthroconidia in coccidioidoma: Case report and literature reviewThoracic coccidioidomycosisCavitary Coccidioidomycosis With Fungus Ball FormationCoccidioides immitis meningitis with arthroconidia in cerebrospinal fluid: Reportof the first case and review of the arthroconidia literatureCase 3-1980Unusual manifestation of Coccidioides immitis infectionCoccidioidomycosisCoccidioidomycosisAnalisis de 6000 especímenes micológicos Sintesis estadística. — ComentariosSURGICAL THERAPY OF CHRONIC PULMONARY HISTOPLASMOSIS WITH AND WITHOUT AMPHOTERICIN BHUMAN COCCIDIOIDOMYCOSIS 1 August 1955Volume 43, Issue 2Page: 255-270KeywordsCoccidioidesCytoplasmGranulomasMedical servicesResearch laboratoriesSputum ePublished: 1 December 2008 Issue Published: 1 August 1955 PDF downloadLoading ...