tbuckley/cabot-search huggingface dataset:
Abstract 2699: Improved Prediction of Cardiac Events with Assessment of Absolute QT and RR Intervals in Adolescent Patients with the Congenital Long QT Syndrome
Authors: Ilan Goldenberg, Arthur J Moss, Scott McNitt, Wojciech Zareba, Derick R Peterson, Mark L Andrews, Jennifer L Robinson
Journal: Circulation (2006)

Background: The QT interval is most commonly corrected for heart rate (QTc) by using Bazett’s formula. However, heart rate correction formulae have several limitations, particularly at fast or slow...
Abstract P294: 25-OH Vitamin D concentration and All-Cause Mortality Following Coronary Catheterization in Alberta, Canada.
Authors: Lawrence de Koning, Michael Gerling, Mei Zhang, Christopher Naugler, Merril Knudtson
Journal: Circulation (2015)

Background: While vitamin D deficiency has been identified as a potential risk marker for cardiovascular disease, little information exists on whether it is associated with outcomes following coronary interventions (e.g. angioplasty). Objective: To examine the association between total 25-OH vitamin D concentration and all-cause mortality among patients undergoing coronary catheterizations in Calgary and Edmonton Alberta for the Alberta Provincial Project for Outcome Assessment in Coronary Heart Disease (APPROACH). Methods: Provincial laboratory data containing the first measurement of 25-OH vitamin D prior to coronary catheterization was merged to APPROACH covariate and outcome data from 2009-2013, defining a sub-cohort of 3358 participants. Data from the 2011 National Household Survey was merged by postal code to provide neighborhood level socioeconomic data. Multiple logistic regression was used to examine the association between 25-OH vitamin D and all-cause mortality. Results: There were a total of 2...
Abstract 1357: Mobility of Epicardial Rotors During Human Ventricular Fibrillation
Authors: Martyn P Nash, Ayman Mourad, Chris P Bradley, David J Paterson, Peter M Sutton, Martin Hayward, Peter Taggart
Journal: Circulation (2007)

Introduction: Stability of reentry during VF may depend on the dynamics of rotor cores. We determined the mobility of rotors during human VF using global epicardial mapping and phase singularity analysis. Methods: In 10 patients undergoing cardiac surgery (6 with coronary artery disease; 4 with aortic valve disease), VF was induced by burst pacing prior to (n=7) or immediately following (n=3) the onset of cardiopulmonary bypass. For each subject, a 20 – 40 s episode of fibrillatory activity was sampled at 1 kHz using an epicardial sock containing 256 unipolar contact electrodes connected to a UnEmap system. Trajectories of persistent epicardial rotors (singularities of phase maps, based on de-trended voltage versus its Hilbert transform, lasting for &gt; 1000 ms) were tracked. The mean core location was determined across the lifetime of each persistent rotor. The rotor was classified as stationary if its core remained within 15 mm of the mean location for more than 90% of its duration. Results: Using the above criteria, the numbers of mobile and stationary rotors varied from patient-to-patient (see figure ). In all but one patient, there were more mobile than stationary rotors. Over all patients, the mean ± SD number of mobile rotors (32 ± 21) was significantly greater than stationary rotors (7 ± 6, P&lt;0.01). Conclusions: At least one stationary rotor was always present during human VF, but it is predominantly characterised by a small number of persistent mobile rotors.
Abstract 13180: Impact of Epicardial Adipose Tissue in Modulating Cardiac Mechanics, Contractile Function and Twist Behavior - Possible Mechanisms in the Transition from Hypertension to Heart Failure Development
Authors: Chung-Lieh Hung, Chun-Ho Yun, Chuan-Chuan Liu, Hung-I Yeh, Charles Jia-Yin Hou, Cheng-Ho Tsai, Ta-Chuan Hung
Journal: Circulation (2011)

Background: Excessive visceral adipose tissue, a central marker of abnormal metabolic process, has recently been shown to exert an independent effect on cardiac struture and to confer increased car...
评论:提高哮喘的诊断率:社区问题
Authors: Hans, Siersted, 吴谨准
Journal: BMJ (1998)

我们对哮喘的定义:同时伴有哮喘样症状和阻塞性气道异常,已被广泛接受。整套试验及诊断规则常规用于临床专业,类似的原则也用于全科医师。因此我们相信,在我们这个以社区为基础的研究中,所诊断出来的哮喘患儿,如果到全科医生那
Abstract 3923: Molecular characterization of an animal model for neuroendocrine thyroid cancer
Authors: Karine Pozo, Antje Hillmann, Alexander Augustyn, Tanvir Singh, Florian Plattner, John Minna, Herbert Chen, Gilbert J. Cote, James A. Bibb, Fiemu E. Nwariaku
Journal: Cancer Research (2014)

Abstract Neuroendocrine tumors are rare forms of cancers originating from hormone-producing cells that are scattered throughout the body. Medullary thyroid carcinoma (MTC) develops from calcitonin-secreting, C cells, in the thyroid gland. Surgical removal of the thyroid is the best treatment currently available for early stage cancer patients but advanced forms of MTC are often incurable and fatal. Thus, better therapies are needed. A lack of relevant animal models for this disease has slowed the development of new treatments. We have recently reported a novel conditional mouse model for MTC. In these mice, overexpression of the cyclin-dependent kinase 5 (Cdk 5), activator, p25 in C cells induces MTC tumors. Furthermore, interruption of p25 overexpression results in growth arrest of these tumors. Here we take advantage of our conditional mouse model to investigate the molecular pathways underlying MTC tumorigenesis. We used Illumina Mouse WG-6 v2.0 Expression BeadChip to compare the gene expression profile of proliferating versus arrested mouse MTC tumors. We found that a total of 920 genes encoding transcription factors, cell cycle proteins, motor proteins and angiogenesis factors were differentially regulated in growing versus arrested tumors. Particularly the genes encoding cell cycle proteins that are involved in the regulation of Rb pathway were significantly up-regulated in the proliferating tumors. Selected genes with higher degrees of change were evaluated by quantitative PCR and immunoblotting analyses. Taken together these findings suggests that the Rb signaling pathways is involved in MTC tumorigenesis and that Cdk5 may act as a critical regulator of the Rb signaling pathway in this cancer. Thus, targeting Cdk5 and/or the Rb pathway may be a valid strategy to stop the progression of neuroendocrine thyroid cancer. Citation Format: Karine Pozo, Antje Hillmann, Alexander Augustyn, Tanvir Singh, Florian Plattner, John Minna, Herbert Chen, Gilbert J. Cote, James A. Bibb, Fiemu E. Nwariaku. Molecular characterization of an animal model for neuroendocrine thyroid cancer. [abstract]. In: Proceedings of the 105th Annual Meeting of the American Association for Cancer Research; 2014 Apr 5-9; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2014;74(19 Suppl):Abstract nr 3923. doi:10.1158/1538-7445.AM2014-3923
An Era in Cardiovascular Medicine
Authors: Suzanne B. Knoebel, Simon Dack
Journal: Annals of Internal Medicine (1991)

Vo,max recorded during a progressive maximal exercise test is a reliable index of exercise capacity,' there are methodological difficulties with the prediction of Vo2max when the Astrand-Ryhming nomogram is used.This nomogram is based upon extrapolation from paired observations of heart rate and either oxygen uptake or (as in the present study) external work rate during a submaximal test.Unfortunately the predic- ted Vo2max may differ widely from the actual Vo,max, the standard error of the estimate
THROMBOANGIITIS OBLITERANS OF PATIENTS WITH DIABETES
Authors: Bayard T. Horton, Frank N. Allan
Journal: Annals of Internal Medicine (1934)

Article1 January 1934THROMBOANGIITIS OBLITERANS OF PATIENTS WITH DIABETESBAYARD T. HORTON, M.D., F.A.C.P., FRANK N. ALLAN, M.D., F.A.C.P.BAYARD T. HORTON, M.D., F.A.C.P.Search for more papers by this author, FRANK N. ALLAN, M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-7-7-799 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptGangrene of the lower extremities in cases of diabetes is due primarily to impairment of circulation and secondarily to the effects of the diabetes on the resistance of the skin to infection. In cases of long standing, without adequate treatment, arteriosclerosis is common. It develops early in life and to a more advanced degree than in nondiabetic patients. In some cases, however, the occlusive process is of a different type. The present report, with the exception of a case reported by Adams in 1930, includes all cases of thromboangiitis obliterans complicated with diabetes observed at The Mayo Clinic. The small...Bibliography1. ADAMS SF: Case of diabetes mellitus with thromboangiitis obliterans, Med. Clin. N. Am., 1930, xiv, 581-583. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Rochester, Minnesota*Submitted for publication April 14, 1933.From the Division of Medicine, The Mayo Clinic. Nextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byThromboangiitis obliterans in a diabetic 1 January 1934Volume 7, Issue 7Page: 799-804KeywordsSkin infections ePublished: 1 December 2008 Issue Published: 1 January 1934 PDF downloadLoading ...
Dissolvable Base Scaffolds Allow Tissue Penetration of High‐Aspect‐Ratio Flexible Microneedles
Authors: Satoshi Yagi, Shota Yamagiwa, Yoshihiro Kubota, Hirohito Sawahata, Rika Numano, Tatsuya Imashioya, Hideo Oi, Makoto Ishida, Takeshi Kawano
Journal: Advanced Healthcare Materials (2015)

Microscale needle technology is important in electrophysiological studies, drug/chemical delivery systems, optogenetic applications, and so on. In this study, dissolvable needle-base scaffold realizes penetration of high-aspect-ratio flexible microneedles (e.g., <5 μm diameter and >500 μm length) into biological tissues. This methodology, which is applicable to numerous high-aspect-ratio flexible microneedles, should reduce the invasiveness and provide safer tissue penetrations than conventional approaches. As a service to our authors and readers, this journal provides supporting information supplied by the authors. Such materials are peer reviewed and may be re-organized for online delivery, but are not copy-edited or typeset. Technical support issues arising from supporting information (other than missing files) should be addressed to the authors. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
THE EFFECTS OF THIOURACIL ON THE THYROID GLAND
Authors: J W SHIRER, M COHEN
Journal: Annals of Internal Medicine (1945)

Article1 November 1945THE EFFECTS OF THIOURACIL ON THE THYROID GLANDJOHN WESLEY SHIRER, M.D., MORTIMER COHEN, M.D., F.A.C.P.JOHN WESLEY SHIRER, M.D.Search for more papers by this author, MORTIMER COHEN, M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-23-5-790 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptSince Plummer1instituted the use of iodine in the preoperative preparation of the thyrotoxic patient in 1923, little has been added to the management of thyroid disease except refinements of technic in the operative procedures. One of the most striking developments in the management of hyperthyroidism has come with the recent advances in chemotherapy. MacKenzie and MacKenzie,2in 1943, showed that sulphonamide treated animals developed goiters and hypometabolism. Astwood3sought a substance allied chemically to the sulphonamides which would be less toxic to human beings. After experimentation, he chose thiourea and thiouracil as the chemicals of least toxicity. He reported...Bibliography1. PLUMMER HS: Results of administering iodine to patients having exophthalmic goiter, Jr. Am. Med. Assoc., 1923, lxxx, 1955. Google Scholar2. MACKENZIEMACKENZIE CGJB: Effects of sulfonamides and thioureas on the thyroid gland and basal metabolism, Endocrinology, 1943, xxxii, 185-209. CrossrefGoogle Scholar3. ASTWOOD EB: Treatment of hyperthyroidism with thiourea and thiouracil, Jr. Am. Med. Assoc., 1943, cxxii, 78-81. CrossrefGoogle Scholar4. MOORESWEENYCOPERAWSONMEANS FDDNORWJH: The use of thiouracil in the preparation of patients with hyperthyroidism for thyroidectomy, Ann. Surg., 1944, cxx, 152-169. CrossrefGoogle Scholar5. GRAHAM A: Personal communication. Google Scholar6. GRAHAM A: The thyroid gland in hyperthyroidism, Surg. Clin. N. Am., 1941, xxi, 1331-1363. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: JOHN WESLEY SHIRER, M.D.; MORTIMER COHEN, M.D., F.A.C.P.Affiliations: Pittsburgh, Pennsylvania*Read at the Regional Meeting of the American College of Physicians, November 11, 1944.From the Departments of Surgery and Pathology, The School of Medicine, University of Pittsburgh, and The Elizabeth Steel Magee Hospital, Pittsburgh, Pennsylvania. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byToward a New European Threshold to Discriminate Illegally Administered from Naturally Occurring Thiouracil in LivestockTHE THYROID GLAND IN THYROTOXICOSIS 1 November 1945Volume 23, Issue 5 Page: 790-799 Keywords Chemotherapy Hospital medicine Hyperthyroidism Surgery Thyroid Thyroid diseases Toxicity ePublished: 1 December 2008 Issue Published: 1 November 1945 PDF downloadLoading ...
Abstract 12735: Differences in the Tolerable Threshold of Right Ventricular Volume Predict Adverse Events in Patients With Pulmonary Arterial Hypertension and Chronic Thromboembolic Pulmonary Hypertension
Authors: Koya Ozawa, Nobusada Funabashi, Hiroyuki Takaoka, Nobuhiro Tanabe, Koichiro Tatsumi, Yoshio Kobayashi
Journal: Circulation (2014)

Introduction:  Right ventricular (RV) volume measurements may predict short term prognosis in patients with pulmonary arterial hypertension (PAH) and chronic pulmonary thromboembolic pulmonary hypertension (PH) (CTEPH) but quantitative thresholds of RV volume that predict occurrence of adverse events (AE) may differ between both groups.   Hypothesis:  To evaluate tolerance of RV volume in PAH and CTEPH patients by comparing quantitative thresholds of RV end diastolic (RVEDV) and end systolic volume (RVESV) by CT as predictors of AE.   Method:  43 confirmed PH patients (14 PAH (4 males, 49 ± 16 yrs) and 29 CTEPH patients (9 males, 58 ± 15 yrs) underwent retrospective ECG gated 320 slice CT (Aquilion one). CT images were reconstructed every 5% from 0-95% of ECG R-to-R interval and RVEDV and RVESV were measured. Subjects were followed for a median of 31.5 months for PAH and 21 months for CTEPH. AE included cardiac death and hospitalization due to heart failure.   Results:  AE occurred in 2 PAH and 3 CTEPH patients. Receiver operating characteristic (ROC) curves of RVEDV and RVESV showed the best cutoff points to distinguish PAH patients with and without AEs were 264.8 cm3 for RVEDV(sensitivity 50%, specificity 100%) and 215.3 cm3 for RVESV (sensitivity 50%, specificity 100%) with AUC of 0.708 and 0.667, respectively. Other ROC curves of RVEDV and RVESV showed the best cutoff points to distinguish CTEPH patients with and without AEs were 210.3 cm3 for RVEDV(sensitivity 100%, specificity 92.3%) and 152.6 cm3 for RVESV (sensitivity 100%, specificity 92.3%) with AUC of 0.923 and 0.923, respectively. There were significant differences by Kaplan Meier analysis in incidence of AEs for PAH patients with RVEDV ≥ and    Conclusion:  RVEDV and RVESV measurements by CT could predict short term prognosis in PAH and CTEPH patients. Quantitative thresholds of RVEDV and RVESV that predict occurrence of AE were greater in PAH than in CTEPH patients. This difference may be due to presence of specific and effective therapy, such as pulmonary endarterectomy in CTEPH, or etiological and pathological differences between groups.
Surveillance for Certain Health Behaviors and Conditions Among States and Selected Local Areas — Behavioral Risk Factor Surveillance System, United States, 2015
Authors: Sonya B. Gamble, Tebitha Mawokomatanda, Fang Xu, Pranesh P. Chowdhury, Carol Pierannunzi, David Flegel, William Garvin, Machell Town
Journal: MMWR Surveillance Summaries (2018)

Chronic conditions and disorders (e.g., diabetes, cardiovascular diseases, arthritis, and depression) are leading causes of morbidity and mortality in the United States. Healthy behaviors (e.g., physical activity, avoiding cigarette use, and refraining from binge drinking) and preventive practices (e.g., visiting a doctor for a routine check-up, tracking blood pressure, and monitoring blood cholesterol) might help prevent or successfully manage these chronic conditions. Monitoring chronic diseases, health-risk behaviors, and access to and use of health care are fundamental to the development of effective public health programs and policies at the state and local levels.
Abstract P396: Presence of Hypertension and the Effect on Clinical Outcome Scores of IV rt-PA Receiving Patients at a Community Primary Stroke Center (PSC) in Urban Los Angeles
Authors: Jennifer Garland, Anna Antonio, Antonio Liu
Journal: Circulation (2014)

Background: Intravenous recombinant tissue plasminogen activator (IV rt-PA) is the only FDA approved thrombolytic treatment for acute ischemic stroke offering at least a 30% chance of improvement over placebo. Purpose: The purpose of the study was to examine the effect of hypertension (HTN) and other various covariates of patients receiving IV rt-PA thrombolysis treatment for ischemic stroke on clinical outcome scores over time: mRS (modified Ranking Scale) &amp; NIHSS (National Institute of Health Stroke Scale). Methods: A retrospective analysis utilized repeated measures design (SAS Windows version 9.3) on patients receiving IV rt-PA thrombolysis treatment for ischemic stroke from Jan 1, 2012 to Dec 31, 2012. The total cohort used for analysis, N=60. Two cases were not included due to death. Baseline measures were taken at admission and one follow-up time point at discharge. All covariates were included first in univariate models. Those which were found to be significant were then included in multivariate analysis. All statistical significance tests were 2-sided, α=.05 was considered statistically significant. Results: In univariate analyses, there is a significant time effect (p=0.0001), evidenced by the decrease in NIHSS over time and a significant difference in average NIHSS scores between those with and without HTN (p=0.0016). A test of interaction of HTN status by time was not significant ( p &gt;0.05). NIHSS scores appear to decrease faster for those without HTN, however, this difference in rate is not significant. Not having HTN was associated with a decrease in mean NIHSS score over time, while having a hemorrhagic transformation (HT) is associated with an increase in mean NIHSS score. Age, gender, ethnicity, and IV rt-PA door to needle time were not found to be significant predictors of mean NIHSS scores over time. Conclusions: Patients with hemorrhagic transformation were associated with poorer clinical outcomes, as expected. These patients receiving IV rt-PA for acute ischemic stroke generally improved, as expected. It was interesting to note that individuals with HTN appear to be admitted and discharged with higher NIHSS scores versus those without HTN, despite HTN being promptly treated when present. This demonstrates the importance of HTN prevention and blood pressure control treatment.
Medication Therapy Management Interventions in Outpatient Settings
Authors: Meera Viswanathan, Leila C. Kahwati, Carol E. Golin, Susan J. Blalock, Emmanuel Coker-Schwimmer, Rachael Posey, Kathleen N. Lohr
Journal: JAMA Internal Medicine (2014)

Medication therapy management (MTM) services (also called clinical pharmacy services) aim to reduce medication-related problems and their downstream outcomes.To assess the effect of MTM interventions among outpatients with chronic illnesses.MEDLINE, Cochrane Library, and International Pharmaceutical Abstracts through January 9, 2014.Two reviewers selected studies with comparators and eligible outcomes of ambulatory adults.Dual review of titles, abstracts, full-text, extractions, risk of bias, and strength of evidence grading. We conducted meta-analyses using random-effects models.Medication-related problems, morbidity, mortality, quality of life, health care use, costs, and harms.Forty-four studies met the inclusion criteria. The evidence was insufficient to determine the effect of MTM interventions on most evaluated outcomes (eg, drug therapy problems, adverse drug events, disease-specific morbidity, disease-specific or all-cause mortality, and harms). The interventions improved a few measures of medication-related problems and health care use and costs (low strength of evidence) when compared with usual care. Specifically, MTM interventions improved medication appropriateness (4.9 vs 0.9 points on the medication appropriateness index, P < .001), adherence (approximately 4.6%), and percentage of patients achieving a threshold adherence level (odds ratios [ORs] ranged from 0.99 to 5.98) and reduced medication dosing (mean difference, -2.2 doses; 95% CI, -3.738 to -0.662). Medication therapy management interventions reduced health plan expenditures on medication costs, although the studies reported wide CIs. For patients with diabetes mellitus or heart failure, MTM interventions lowered the odds of hospitalization (diabetes: OR, 0.91 to 0.93 based on type of insurance; adjusted hazard rate for heart failure: 0.55; 95% CI, 0.39 to 0.77) and hospitalization costs (mean differences ranged from -$363.45 to -$398.98). The interventions conferred no benefit for patient satisfaction and most measures of health-related quality of life (low strength).We graded the evidence as insufficient for most outcomes because of inconsistency and imprecision that stem in part from underlying heterogeneity in populations and interventions. Medication therapy management interventions may reduce the frequency of some medication-related problems, including nonadherence, and lower some health care use and costs, but the evidence is insufficient with respect to improvement in health outcomes.
Inflammatory arthritis following ustekinumab treatment for psoriasis: a report of two cases
Authors: A. de Souza, T. Ali-Shaw, S.M. Reddy, D. Fiorentino, B.E. Strober
Journal: British Journal of Dermatology (2012)

Journal Article Inflammatory arthritis following ustekinumab treatment for psoriasis: a report of two cases Get access A. de Souza, A. de Souza Department of Dermatology A. de Souza. E‐mail: aieska@yahoo.com Search for other works by this author on: Oxford Academic Google Scholar T. Ali‐Shaw, T. Ali‐Shaw Department of Dermatology Search for other works by this author on: Oxford Academic Google Scholar S.M. Reddy, S.M. Reddy New York University Hospital for Joint Disease, New York University School of Medicine, New York, NY, U.S.A Search for other works by this author on: Oxford Academic Google Scholar D. Fiorentino, D. Fiorentino Department of Dermatology, Stanford University School of Medicine, Redwood City, CA, U.S.A Search for other works by this author on: Oxford Academic Google Scholar B.E. Strober B.E. Strober Department of Dermatology, University of Connecticut School of Medicine, Farmington, CT, U.S.A Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 168, Issue 1, 1 January 2013, Pages 210–212, https://doi.org/10.1111/j.1365-2133.2012.11206.x Published: 01 January 2013 Article history Accepted: 13 June 2012 Published: 01 January 2013