UNILATERAL RENAL DISEASE AS A CAUSE OF HYPERTENSION: ITS DETECTION BY URETERAL CATHETERIZATION STUDIES
Authors: T B CONNOR, W C THOMAS, L HADDOCK, J E HOWARD
Journal: Annals of Internal Medicine (1960)

Article1 March 1960UNILATERAL RENAL DISEASE AS A CAUSE OF HYPERTENSION: ITS DETECTION BY URETERAL CATHETERIZATION STUDIESTHOMAS B. CONNOR, M.D., WILLIAM C. THOMAS JR., M.D., LILLIAN HADDOCK, M.D., JOHN EAGER HOWARD, M.D.THOMAS B. CONNOR, M.D., WILLIAM C. THOMAS JR., M.D., LILLIAN HADDOCK, M.D., JOHN EAGER HOWARD, M.D.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-52-3-544 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptIt has been amply demonstrated experimentally that renal ischemia can result in hypertension1-3 and that, in man, reduced arterial flow to one kidney may produce a clinical picture indistinguishable at the bedside from so-called "essential" hypertension.4-7 Following Butler's initial observations in 1937 of the relief of hypertension in a child after the removal of a diseased kidney,8 many reports appeared on the results of nephrectomy for hypertension. Up to 1954 the percentage of "cures" in any sizable series of cases was remarkably low, and rarely did more than 20% of operations provide the desired fall in blood pressure.9-11The search...Bibliography1. GoldblattLynchHanzalSummerville HJRFWW (a) : Studies on experimental hypertension. I. The production of persistent elevation of systolic blood pressure by means of renal ischemia, J. Exper. Med. 59: 347, 1934. (b) Goldblatt, H.: The renal origin of hypertension, 1948, Charles C Thomas, Springfield, Illinois. CrossrefMedlineGoogle Scholar2. WilsonByrom CFB: Renal changes in malignant hypertension; experimental evidence, Lancet 1: 136, 1939. CrossrefGoogle Scholar3. Drury DR: The production by a new method of renal insufficiency and hypertension in the rabbit, J. Exper. Med. 68: 693, 1938. CrossrefMedlineGoogle Scholar4. HowardBerthrongSloanYendt JEMRDER: Relief of malignant hypertension by nephrectomy in four patients with unilateral renal vascular disease, Tr. A. Am. 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Author, Article, and Disclosure InformationAffiliations: Baltimore, Maryland*Received for publication September 29, 1959.†Presented in part at the Fortieth Annual Session of The American College of Physicians, Chicago, Illinois, April 21, 1959.From the Department of Medicine, The Johns Hopkins University School of Medicine and Hospital, and the Department of Medicine, University of Maryland, School of Medicine, Baltimore, Maryland.This work supported in part by Grant No. 2A-5058 from the Institute of Arthritis and Metabolic Diseases of the National Institutes of Health (U.S.P.H.S.).‡Present address: Department of Medicine, University of Florida College of Medicine, Gainesville, Florida.§Trainee, National Institute of Arthritis and Metabolic Diseases, Department of Medicine, Johns Hopkins University School of Medicine. Present address: Department of Medicine, San Juan City Hospital, San Juan, Puerto Rico.Requests for reprints should be addressed to Thomas B. Connor, M.D., Department of Medicine, University Hospital, Baltimore 1, Maryland. 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