THE SYNDROME OF INTESTINAL CARCINOID, PULMONARY VALVULAR STENOSIS AND CUTANEOUS FLUSH
Authors: G Y MILLS
Journal: Annals of Internal Medicine (1956)

Case Reports1 December 1956THE SYNDROME OF INTESTINAL CARCINOID, PULMONARY VALVULAR STENOSIS AND CUTANEOUS FLUSHG. Y. MILLS, M.D.G. Y. MILLS, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-45-6-1213 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe details of the comparatively new and, indeed, bizarre clinical entity of argentaffinoma, pulmonary stenosis and cutaneous flush are not well documented. Patients with this triad present a confusing picture, since the findings appear at present to be completely unrelated. Until recently the problems in diagnosis have, with few exceptions, continued to necropsy. Some evidence has been accumulated which suggests very strongly that the intestinal disease and cutaneous signs are related. The heart disease is not always overt and, when found to be a pulmonary stenosis, serves to link the three parts of this triad into a well defined disease....Bibliography1. Cassidy MA: Abdominal carcinomatosis with probable adrenal involvement, Proc. Roy. Soc. Med. 24: 139, 1930. CrossrefMedlineGoogle Scholar2. Scholte AJ: Ein Fall von Angioma telangiectaticum cutis mit chronischer Endokarditis und malignem Dümmdarmcarcinoid, Beitr. z. path. Anat. u. z. allg. Path. 86: 440, 1931. Google Scholar3. Cassidy MA: Post mortem findings in a case of abdominal carcinomatosis, Proc. Roy. Soc. Med. 24: 920, 1931. CrossrefMedlineGoogle Scholar4. BjörckAxenThorson GOA: Unusual cyanosis in a boy with congenital pulmonary stenosis and tricuspid insufficiency, Am. Heart J. 44: 143, 1952. CrossrefMedlineGoogle Scholar5. RosenbaumSanterClaudon FFDGB: Essential telangiectasia, pulmonic and tricuspid stenosis and neoplastic liver disease: a possible new clinical syndrome, J. Lab. and Clin. Med. 42: 941, 1953. Google Scholar6. IslerHedinger CC: Metastatic carcinoid of small intestine with severe valvular defects, especially in the right heart and with pulmonary stenosis, a peculiar symptom complex, Schweiz. med. Wchnschr. 83: 4, 1953. MedlineGoogle Scholar7. Ljung O: Carcinoid associated with intense facial hyperemia, Nord. med. 50: 30, 1953. Google Scholar8. HedingerGloor CR: Metastatic intestinal carcinoid, tricuspid valvular changes and pulmonary stenosis, Schweiz. med. Wchnschr. 84: 33, 1954. MedlineGoogle Scholar9. ThorsonBjörckBjorkmanWaldenström AGGJ: Malignant carcinoid of the small intestine with metastases to the liver, valvular disease of the right side of the heart, peripheral vasomotor symptoms, bronchoconstriction and an unusual type of cyanosis, Am. Heart J. 47: 795, 1954. CrossrefMedlineGoogle Scholar10. VialliErspamer MV: Cellule enterochromaffin e cellule Basigranulose acidophile nei vertebrate, Ztschr. f. Zellforsch. u. mikr. Anat. 19: 743, 1933. CrossrefGoogle Scholar11. RapportGreenPage MMAAIH: Crystalline serotonin, Science 108: 329, 1948. CrossrefMedlineGoogle Scholar12. RapportGreenPage MMAAIH: Partial purification of vasoconstrictor in beef serum, J. Biol. Chem. 174: 735, 1948. CrossrefMedlineGoogle Scholar13. HamlinFischer KEFE: The synthesis of 5-hydroxy tryptamine, J. Am. Chem. Soc. 73: 5007, 1951. CrossrefGoogle Scholar14. RapportGreenPage MMAAIH: Enzymatic inactivation of serum vasoconstrictor, Proc. Soc. Exper. Biol. and Med. 68: 582, 1948. CrossrefMedlineGoogle Scholar15. Gaddum JH: Antagonism between lysergic acid diethylamide and 5-hydroxy tryptamine, J. Physiol. 121: 158, 1953. Google Scholar16. Erspamer V: Pharmakologische Studien über Enteramine, Arch. f. exper. Path. u. Pharmakol. 196: 366, 1940. CrossrefGoogle Scholar17. ReidRand GM: Physiological actions of partially purified serum vasoconstrictor, Australian J. Exper. Biol. and M. Sc. 29: 401, 1951. CrossrefMedlineGoogle Scholar18. ComroeVan LingenStraudRoncoroni JHBRCA: Reflex and direct cardio-pulmonary effects of 5 hydroxy-tryptamine, Am. J. Physiol. 173: 379, 1953. CrossrefMedlineGoogle Scholar19. PageMcCubbin IHJW: Variable arterial pressure response to serotonin in laboratory animals and man, Circul. Res. 1: 354, 1953. CrossrefMedlineGoogle Scholar20. ReidRand GM: Principal actions of synthetic 5-hydroxy tryptamine (serotonin, thrombocytin), Nature, London 169: 801, 1952. CrossrefMedlineGoogle Scholar21. ArnethLong JHC: A case of congenital stenosis of the pulmonary valve with late onset of cyanosis. Death from carcinoma of the pancreas, Am. J. M. Sc. 182: 212, 1931. CrossrefGoogle Scholar22. BranwoodBain AWAD: Carcinoid tumors of the small intestine, Lancet 2: 1259-1261 (Dec. 18) 1954. CrossrefGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Chicago, Illinois*Received for publication February 6, 1956.From the Department of Medicine, Michael Reese Hospital, Chicago.Requests for reprints should be addressed to G. Y. Mills, M.D., Department of Medicine, Michael Reese Hospital, Chicago 16, Illinois. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited bySemimaligne Primärtumoren der Bronchien und LungenKlinik und Pathophysiologie des Karzinoids und Karzinoidsyndroms unter besonderer Berücksichtigung der Pharmakologie des 5-HydroxytryptaminsCARCINOID HEART DISEASEREFERENCES 1 December 1956Volume 45, Issue 6Page: 1213-1221KeywordsCardiovascular therapyEmotionsHeart diseasesHospital medicineMucous membranesPathogenesisPulmonary diseasesStenosis Issue Published: 1 December 1956 PDF downloadLoading ...