tbuckley/cabot-search huggingface dataset:
Selection and Biologic Properties of Malignant Variants of a Murine Lymphosarcoma&lt;xref ref-type="fn" rid="FN2"&gt;2&lt;/xref&gt;
Authors: Kenneth W. Brunson, Garth L. Nicolson
Journal: JNCI Journal of the National Cancer Institute (1978)

A syngeneic tumor model system with the RAW117 lymphosarcoma cell line was developed for use in investigations of host and tumor cell properties associated with an enhanced state of malignancy. This BALB/c mouse model was found to be similar to human lymphosarcoma in that liver and spleen were the major organs involved. Sequential in vivo selections were performed by iv tumor cell inoculation, removal of resulting solid liver tumor nodules for growth in vitro, and reinjection of the cultured cells iv. After ten such sequential selections for implantation, invasion, survival, and growth in liver, a lymphosarcoma cell line was obtained (RAW 117-H10) that formed approximately 200-fold more gross liver tumor nodules than did the parental tumor cell line in comparative biologic assays and displayed enhanced malignant properties when monitored by time of host death. Very few lung nodules or tumors were present at other sites with either the parental or any of the selected RAW117 lines, which confirms previous reports in which in vivo sequential selection yielded stable cell lines with preferential tumor colonization at specific sites.
Heterogeneity of type III procollagen N-terminal peptides in BAL fluid from normal and fibrotic lungs
Authors: NK Harrison, RJ McAnulty, WG Kimpton, None Fraser, TC Laurent, GJ Laurent
Journal: European Respiratory Journal (1993)

Levels of the N-terminal propeptide of type III collagen (PIIINP) in bronchoalveolar lavage fluid (BALF) are thought to reflect type III collagen production by the lungs, and increased levels have been reported in patients with pulmonary fibrosis. We wanted to know more about the relative proportions of these peptides in normal BALF, whether they altered in pulmonary fibrosis, and whether lymphoid tissue is capable of clearing PIIINPs. In this study, we used a radioimmunoassay which detects the different forms of PIIINP-related antigens with equal specificity, to measure PIIINPs in serum and BALF of patients with cryptogenic fibrosing alveolitis (CFA). To investigate why PIIINP profiles in BALF differed from serum, the absolute concentration and relative proportion of PIIINPs in lymph afferent and efferent to the popliteal lymph node of a sheep were also determined. PIIINP concentrations were significantly greater in serum and BALF of patients with CFA, compared with controls. Gel chromatography indicated that serum antigen distribution, both of patients and controls, contained approximately 20% Col 1-3; the remainder being Col 1. In contrast, BALF contained Col 1-3 and Col 1, together with an antigen of high molecular weight (> 150 kD). The relative proportion of each antigen varied quite widely, but there were no apparent differences between patients and controls. The concentration of PIIINPs in afferent lymph was 295 ng.ml-1 and in efferent lymph was 104 ng.ml-1. Gel chromatography demonstrated that a significant amount of Col 1-3, together with a high molecular weight peptide, had been cleared during passage through the node.(ABSTRACT TRUNCATED AT 250 WORDS)
Effects of cigarette smoking intensity on functional capacity of active smokers
Authors: Rafaella Xavier, Dionei Ramos, Fernanda Rodrigues, Juliana Ito, Giovana Bertolini, Bruna Spolador, Alessandra Toledo, Ercy Ramos
Journal: European Respiratory Journal (2013)

Smokers have increased airflow resistence and reduced exercise tolerance. Aim: To evaluate the effects of smoking intensity on functional capacity of active smokers. Methods: 54 smokers were divided into light (LS) (1-10 cigarettes/day (c/d); n=10), moderate (MS) (11-20 c/d; n=12) and heavy smokers (HS) (³21 c/d; n=32). The smoking behaviour, pulmonary function, and functional capacity (six minutes walk test - 6MWT) were evaluated. The heart rate (HR), peripheral oxygen saturation (SpO2) and systolic (SBP) and diastolic (DBP) blood pressure were evaluated before, immediately and two minutes after recovery the 6MWT. An age-matched non smoker (NS) group (n=13) was also assessed. Comparisons between groups were conducted by Kruskal-Wallis, followed by Dunn’s. For comparison among 6MWT variables, numerical deltas (Δ) were calculated for the HR, SpO2, SBP and DBP Results: MS and HS walked less than NS in 6MWT (P=0,001). HS had lower FEV1 than NS (P=0,003). Furthermore, the HR of NS increased more immediately after 6MWT (P  Conclusion: MS and HS had lower functional capacity than NS and smoking had a bad hemodynamic repercussion in the 6MWT.
The treatment of sub massive pulmonary embolism: Thrombolytic or heparin?
Authors: Gulfer Okumus, Mehtap Ertas, Zuleyha Bingol, Esen Kiyan, Ahmet Kaya Bilge, Halim Issever, Orhan Arseven
Journal: European Respiratory Journal (2012)

Introduction:  Thrombolytic therapy (TT) decreases mortality and morbidity in the patients with massive pulmonary embolism (PE) when compared to heparin therapy. However the use of TT in patients with sub-massive PE remains controversial.  The aim of these studys to compare the efficiency of heparin and TT for sub-massive PE.   Material and method:  Patients with sub-massive PE who were treated during the last five years were included in this study. Patients who have significant hypoxemia or expansive thrombosis or proximal DVT were given TT and the others were given heparin. These groups were compared for demographics, risk factors and echocardiography findings (72nd hour, 6th and 12th month).   Results:  Totally 39 patients (20 female, 19 male) were included. The mean age was 57years, the mean duration of follow up was 3,5 years. There was no difference for age, gender, risk factors between TT (n=20) and heparin (n=19) groups. Mean pulmonary arterial pressure (PAP) was 49mmHg in heparin group and 64mmHg in TT group. PAP at 72nd hour was significantly lower in TT group than the heparin group (p   Conclusion:  As a result of our study TT decreases PAP significantly at 72nd hour in the patients with sub-massive PE so that TT could be the first choice therapy for these patients.
Sustained Tumor Regression of Human Colorectal Cancer Xenografts Using a Multifunctional Mannosylated Fusion Protein in Antibody-Directed Enzyme Prodrug Therapy
Authors: Surinder K. Sharma, R. Barbara Pedley, Jeetendra Bhatia, Geoffrey M. Boxer, Ethaar El-Emir, Uzma Qureshi, Berend Tolner, Helen Lowe, N. Paul Michael, Nigel Minton, Richard H. J. Begent, Kerry A. Chester
Journal: Clinical Cancer Research (2005)

Antibody-directed enzyme prodrug therapy (ADEPT) requires highly selective antibody-mediated delivery of enzyme to tumor. MFE-CP, a multifunctional genetic fusion protein of antibody and enzyme, was designed to achieve this by two mechanisms. First by using a high affinity and high specificity single chain Fv antibody directed to carcinoembryonic antigen. Second by rapid removal of antibody-enzyme from normal tissues by virtue of post-translational mannosylation. The purpose of this paper is to investigate these dual functions in an animal model of pharmacokinetics, pharmacodynamics, toxicity, and efficacy.MFE-CP was expressed in the yeast Pichia pastoris and purified via an engineered hexahistidine tag. Biodistribution and therapeutic effect of a single ADEPT cycle (1,000 units/kg MFE-CP followed by 70 mg/kg ZD2767P prodrug at 6, 7, and 8 hours) and multiple ADEPT cycles (9-10 cycles within 21-24 days) was studied in established human colon carcinoma xenografts, LS174T, and SW1222.Selective localization of functional enzyme in tumors and rapid clearance from plasma was observed within 6 hours, resulting in tumor to plasma ratios of 1,400:1 and 339:1, respectively for the LS174T and SW1222 models. A single ADEPT cycle produced reproducible tumor growth delay in both models. Multiple ADEPT cycles significantly enhanced the therapeutic effect of a single cycle in the LS174T xenografts (P = 0.001) and produced regressions in the SW1222 xenografts (P = 0.0001), with minimal toxicity.MFE-CP fusion protein, in combination with ZD2767P, provides a new and successful ADEPT system, which offers the potential for multiple cycles and antitumor efficacy. These results provide a basis for the next stage in clinical development of ADEPT.
Metabolic perfil in obese and non-obese OSA children
Authors: Silke Weber, Erico Moreira Silva, Sergio Trindade, Priscila Rocha, Marcos Pereira Filho
Journal: European Respiratory Journal (2013)

Introduction: OSA is a possible risk factor for metabolic syndrome even in children. Objectives: To examine the relationship between metabolic markers (glucose, insuline resistance and lipids) and SDB in children and the impact on quality of life. Methods: 89 children, aged 3-12 years, were matched into 4 groups: G1:non-obese OSA, G2:obese OSA G3-obese, G4 healthy control. OSA was definded by polysomnographic result. Quality of life was assessed by the OSA 18 questionnaire. Metabolic markers (glucose, insulin, total cholesterol, HDL, LDL, VLDL and TGL) were measured on a fasting morning blood sample and were compared in the 4 groups. Results: OSA 18 revealed the negative impact on quality of life in OSA children in the domains: sleep disturbance, physical suffering and caregivers concerns. OSA severity (IAHm) was similar for G1 and G2. Insuline, HOMA and Glucose/Insuline were highest for obese children (G2 and G3), independent of OSA diagnosis. Cholesterol showed no difference for the 4 groups, but HDL was higher in non-obese (G1, G4), triglycerides were higher in obese (G3). Conclusions: OSA causes impairment on quality of life in children. For this population, we found no impact of OSA on the metabolic markers. Obesity was determinant on metabolic dysfunction and insulin resistance.
Induction of gp70-Specific Suppressor T-Cells in Mice Inoculated With Virus-Producing Tumor Cells&lt;xref ref-type="fn" rid="FN2"&gt;2&lt;/xref&gt;&lt;xref ref-type="fn" rid="FN3"&gt;3&lt;/xref&gt;
Authors: Jeffrey A. Bluestone, Carlos Lopez
Journal: JNCI Journal of the National Cancer Institute (1982)

Inoculation of BALB/c mice with syngeneic, murine leukemia virus (MuLV)-producing (murine sarcoma virus-transformed) Balb/3T3 tumor cells resulted in diminution of alloreactivity as measured in the mixed leukocyte culture (MLC) reaction. Cells that suppressed this response were identified in the spleens of tumor-bearing mice 10--14 days after inoculation. The suppressor cells were adherent, radiosensitive T-lymphocytes of the Lyt 1-, 2, 3+ phenotype. Mice inoculated with Gross MuLV (G-MuLV)-producing tumor cells, but not those inoculated with a nonproducing subclone of the same tumor cells, developed suppressor T-cells. The T-cell-mediated suppression of the MLC could be augmented by the admixture of G-MuLV antigen, similar to that replicated by the tumor cell, but not by the admixture of a Rauscher-type MuLV antigen which lacked the cross-reactive, type-specific antigens of the G-MuLV. Furthermore, this augmented suppression could be abrogated by the addition of monoclonal anti-gp70 antibody. These findings indicated that antigen-specific suppressor T-cells were induced in response to leukemia virus antigen shed from and/or expressed on tumor cells and that the suppressive activity involved the specific recognition of the gp70 portion of the virus.
The Influence of Stilbestrol on Skin Tumors Induced in Mice with Tobacco Tar and Methylcholanthrene
Authors: Donald J. Svoboda
Journal: Cancer Research (1961)

Experiments were carried out on 400 Swiss female mice to determine the effect of continuous, long-term absorption of stilbestrol on the incidence of skin tumors induced with 3-methylcholanthrene and the neutral fraction of tobacco tar. The incidence of carcinoma in the methylcholanthrene-plus-stilbestrol group was 39 per cent, whereas in the methylcholanthrene-only group the incidence was 17 per cent. Induction times in the two groups were similar. There was no enhancement of malignant tumor formation by stilbestrol among the animals painted with tobacco tar. After 15 months of application there were nine carcinomas among mice given tobacco tar only. Four papillomas occurred in the tobacco tar-plus-stilbestrol group. Keratoacanthomas were observed in several animals.
Differential growth factor-induced modulation of proteoglycans synthesized by normal human renal versus cyst-derived cells.
Authors: J Kovacs, F A Carone, Z Z Liu, S Nakumara, A Kumar, Y S Kanwar
Journal: Journal of the American Society of Nephrology (1994)

In polycystic kidney disease (PKD), there is an insiduous enlargement of the kidneys and dilation of the renal tubules associated with extracellular matrix (ECM) alterations. The latter include thickening of tubular basement membrane and decreased synthesis of sulfated proteoglycan (PG). Because PKD is believed to be a disorder of cell growth and deranged ECM metabolism, it is conceivable that the formation of cystic tubules may be modulated by certain growth factors (GF) that influence the synthesis of ECM glycoproteins. In this study, the effect of various GF, i.e., epidermal, hepatocyte (HGF) and transforming (TGF), and triiodothyronine on the PG synthesized by normal human kidney (NK) epithelial cells and cells derived from cysts of patients with autosomal dominant PKD (ADPKD) was assessed. (35S) sulfate incorporation studies revealed that, among various GF, HGF and TGF-beta 1 had the maximal stimulatory effect on the synthesis of PG extracted from ADPKD cells. A minimal increase in the PG synthesis was observed in NK cells; however, PG synthesized under the influence of HGF or TGF-beta 1 were of relatively higher molecular weight, with a shift of K(av) from 0.28 to 0.12, as ascertained by Sepharose-6B chromatography. PG synthesized by ADPKD cells had a K(av) = 0.18, and it did not change with the GF treatment. The charge-density characteristics of PG of ADPKD cells were relatively lower than those of NK cells, and they were unaffected by HGF or TGF-beta 1 treatment. Interestingly, both the HGF and TGF-beta 1 significantly affected posttranslational modifications of PG.(ABSTRACT TRUNCATED AT 250 WORDS)
Abstract 172: Lumican-null Mice Are Susceptible to Aging and Isoproterenol-induced Myocardial Fibrosis
Authors: Pao-Hsien Chu
Journal: Circulation Research (2014)

Aims: With aging and stresses, the myocardium undergoes structural remodeling and often leading to fibrosis. Main Methods: To examine whether lumican, one of the class II small leucine-rich proteoglycans, has a role in cardiac remodeling and fibrosis, we analyzed the basic cardiac phenotypes of lumican-null (Lum-/-) mice in both youth and elder, and then used the isoproterenol-induced cardiac fibrosis model to study the roles of extra-cellular matrix and apoptosis in cardiac remodeling. Key Findings: Higher mortality resulted from significantly impaired systolic function, and an increase of atrial natriuretic peptide secreted by the ventricles in response to excessive stretching of myocytes of Lum-/- mice in comparison to wild type littermates. In addition, Lum-/- mice exhibited higher level of TGF-β, collagen I/III, and membrane-type matrix metalloproteinase-1 (MT1-MMP, or MMP-14) during cardiac remodeling. Significance: Our data implicates that the lumican protein plays an important role in the pathogenesis of cardiac fibrosis.
Nature of Ovarian-Adrenal Dysfunction in Breast Cancer Patients2
Authors: Mitsuo Kodama, Toshiko Kodama, Shigeto Miura, Minoru Yoshida, Hiroshi Takagi, Ryozo Totani, Toyokazu Ooki
Journal: JNCI Journal of the National Cancer Institute (1979)

Journal Article Nature of Ovarian-Adrenal Dysfunction in Breast Cancer Patients Get access Mitsuo Kodama, Mitsuo Kodama 3Laboratory of Chemotherapy, Aichi Cancer Center Research Institute, Chikusa-Ku, Nagoya, Japan. Search for other works by this author on: Oxford Academic PubMed Google Scholar Toshiko Kodama, Toshiko Kodama 3Laboratory of Chemotherapy, Aichi Cancer Center Research Institute, Chikusa-Ku, Nagoya, Japan. Search for other works by this author on: Oxford Academic PubMed Google Scholar Shigeto Miura, Shigeto Miura 4Second and Third Departments of Surgery, Aichi Cancer Center Hospital, Nagoya. Search for other works by this author on: Oxford Academic PubMed Google Scholar Minoru Yoshida, Minoru Yoshida 4Second and Third Departments of Surgery, Aichi Cancer Center Hospital, Nagoya. Search for other works by this author on: Oxford Academic PubMed Google Scholar Hiroshi Takagi, Hiroshi Takagi 4Second and Third Departments of Surgery, Aichi Cancer Center Hospital, Nagoya. Search for other works by this author on: Oxford Academic PubMed Google Scholar Ryozo Totani, Ryozo Totani 5Department of Obstetrics and Gynecology, Nagoya National Hospital, Nagoya. Search for other works by this author on: Oxford Academic PubMed Google Scholar Toyokazu Ooki Toyokazu Ooki 6Japan Electron Optics Laboratory Co., Ltd., Tokyo, Japan. 7We thank Miss T. Hayashi, Mrs. T. Yokochi, Mrs. K. Yamauchi, and Miss M. Takayanagi for excellent technical assistance and Dr. Chizuko Takagi, Hakuai Hospital, Nagoya, for the supply of clinical materials. Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 63, Issue 3, September 1979, Pages 599–608, https://doi.org/10.1093/jnci/63.3.599 Published: 01 September 1979 Article history Received: 19 September 1978 Accepted: 14 March 1979 Published: 01 September 1979
Genital exhibitionism in women
Authors: M H Hollender, C W Brown, H B Roback
Journal: American Journal of Psychiatry (1977)

Historically, genital exhibitionism has usually been regarded as an exclusively male phenomenon. The authors present a case study of a female exhibitionist which is at variance with that contention. They offer a formulation of the psychodymanics of female exhibitionism, focusing on its pregenital, attention-seeking purpose. The findings from this case justify a critical reexamination of the traditional definitions of exhibitionism.
The hypothetical role of FoxO1 is interesting, but more study is needed before any conclusions can be drawn - reply from author
Authors: B.C. Melnik
Journal: British Journal of Dermatology (2010)

Conflicts of interest: none declared. Madam, It is my pleasure to respond to the comments of Leyden et al. on my proposed FoxO1 (Forkhead box O transcription factor) hypothesis of acne and retinoid action.1 FoxO1 plays a pivotal role in the regulation of androgen receptor (ARs), cell proliferation, cell survival, apoptosis, lipid and glucose metabolism, oxidative stress and innate immunity – all important factors in acne pathogenesis (Fig. 1).2 Nuclear FoxO1 is predominantly regulated by the activity of the phosphoinositol‐3 kinase/Akt pathway. Increased growth factor signalling in puberty (insulin‐like growth factor‐1, IGF‐1) and an insulinotropic Western diet, especially by high‐glycaemic load diets (insulin) and increased consumption of insulinotropic dairy products (insulin/IGF‐1), may play a fundamental role in the reduction of the nuclear content of FoxO1.3 A decade ago, Deplewski and Rosenfield4 suggested that serum IGF‐1 levels follow the natural course of acne much more closely than serum androgen concentrations. Notably, isotretinoin has recently been shown to reduce serum growth hormone and IGF‐1 serum levels in patients with acne,5 an effect that may counterbalance the decreased nuclear FoxO1 levels of puberty and an insulinotropic Western diet.
Bleomycin-Induced Lung Toxicity and Pentoxifylline
Authors: John Goffin, Harvey Kreisman, Victor Sandor
Journal: Journal of Clinical Oncology (2001)

Article Tools SPECIAL DEPARTMENTS Article Tools OPTIONS & TOOLS Export Citation Track Citation Add To Favorites Rights & Permissions COMPANION ARTICLES No companion articles ARTICLE CITATION DOI: 10.1200/JCO.2001.19.2.597 Journal of Clinical Oncology - published online before print September 21, 2016 PMID: 11208860 Bleomycin-Induced Lung Toxicity and Pentoxifylline John GoffinxJohn GoffinSearch for articles by this author , Harvey KreismanxHarvey KreismanSearch for articles by this author , Victor SandorxVictor SandorSearch for articles by this author Show More McGill University, Montreal, Canada https://doi.org/10.1200/JCO.2001.19.2.597 First Page Full Text PDF Figures and Tables © 2001 by American Society of Clinical Oncology
Aşılama ile indüklenen kutanöz psödolenfoma
Authors: Eve Maubec, Laure Pinquier, Manuelle Viguier, Frédéric Caux, Emmanuelle Amsler, Sélim Aractingi, Hafid Chafi, Anne Janin, Jean-Michel Cayuela, Louis Dubertret, François-Jérôme AuthierveHervé BachelezParis, Créteil ve Bobigny, Morocco
Journal: Journal of the American Academy of Dermatology (2005)
Bronchial thermoplasty in patients with poorly controlled asthma: Three cases
Authors: Turhan Ece, Zuleyha Bingol, Zeynep Yegin
Journal: European Respiratory Journal (2014)

Introduction:  Bronchial thermoplasty (BT) is a new technique for uncontrolled asthma. It delivers thermal energy to the large airways and decrease the amount of smooth muscle. BT has been shown to reduce asthma exacerbations, and improve asthma control and quality of life.   Metods:  Stable adult asthmatics requiring optimal inhaler treatment (beclomethasone ≥200μg, salmeterol ≥100μg), post-bronchodilator FEV1 50-80% predicted; and, non- smoker for 1yr or former smoker    Case I:  A 45year-old male with uncontrolled asthma for 20 years, underwent BT. He had been receiving optimal medical therapy with p.o prednisolone 8mg/daily. Symptoms did not persist after BT. FEV1 prior to BT was 65% (1830ml), ACQ: 4, ACT:11. During 12 week follow-up, FEV1: 44% (1480ml), ACQ:1 and ACT:23.   Case II:  A 45year-old female with uncontrolled asthma for 14 years underwent BT. She were receiving optimal medical therapy with p.o prednisolone 16mg/daily and omalizumab. FEV1 prior to BT was 82% (3610ml), ACQ: 5,5, ACT: 5. During 12 weeks follow-up, FEV1 was 89% (3940ml), ACQ: 0,2 and ACT: 25.   Case III:  A 40-year-old male with uncontrolled asthma for 20 years, underwent BT. He had been receiving optimal medical therapy with p.o prednisolone 16mg/daily. Heamoptysis (10cc) occured a week after third seance. Symptoms improved after BT. FEV1 prior to BT was 66 % (2370ml), ACQ:2.7, ACT:5. During 12 week follow-up, FEV1:65% (2340ml), ACQ:0.8 and ACT:25.   Conclusion:  Response to BT varies from one patient to another. Further studies with different asthma phenotypes are required to define the better responders from BT.