tbuckley/cabot-search huggingface dataset:
Topical Immunotherapy of Basal Cell Carcinomas with Dinitrochlorobenzene
Authors: William R. Levis, Kenneth H. Kraemer, Walter G. Klingler, Gary L. Peck, William D. Terry
Journal: Cancer Research (1973)

Summary  One hundred thirteen tumors in 5 dinitrochlorobenzene (DNCB)-sensitized patients with multiple basal cell carcinomas were treated with topical DNCB. Thirty-six of the 113, or 32%, showed complete clinical regression, for periods of 5 to 18 months. An additional 29% (33 or 113) showed partial regression. DNCB induced only 15 to 25% complete regression in 4 of the 5 patients, whereas 21 of 30, or 70% of basal cell carcinomas treated with DNCB underwent complete regression in the 5th patient. In addition to variation of patient response, there was variation of response of tumors on the same patient. Photographic data presented separately are of a 6th patient with uncountable confluent basal cell carcinomas who responded well to DNCB, but in whom accurate quantification on an individual tumor basis was not possible.  Controls in this study included 63 untreated tumors that were adjacent to and distant from treated tumors. These control tumors showed no evidence of regression. Eleven tumors treated with inert vehicles did not respond. One subject with over 100 nodular basal cell carcinomas became tolerant to DNCB and failed to respond to high concentrations of the drug. Croton oil, a primary irritant that induces inflammation without evidence of cell-mediated immunity, did cause complete regression in 6 of 26 (23%) treated tumors.  The mechanism of DNCB-induced regression of basal cell carcinoma remains unknown. The disappearance of locally invasive human cancer following the therapeutic imposition of a controlled allergic contact dermatitis provides a useful model for the study of immunotherapy of cancer in humans.
Food Analysis. Typical Methods and the Interpretation of Results.
Authors: Alpheus Grant Woodman
Journal: JAMA (1925)

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Expression of ABL related gene (ABL2), a menber of non tyrosine kinase proteins in Burkitt's lymphoma
Authors: Mansoor Salehi, Zahra Kabiri, Felora Rajaei, Mohammad Noori Daloii
Journal: Clinical Cancer Research (2007)

A64  There are some evidences on involvement of ABL2 in a number of cancers. ABL2 overexpression was especially observed in Raji, a Burkitt9s lymphoma (BL) cell line. Therefore ABL2 over expression may be involved in pathogenesis of Burkitt9s lymphoma. The aim of this study was to evaluate ABL2 significance in BL.  Formaldehyde fixed paraffin embedded blocks were from 20 samples, of which 16 were BL and 4 normal lymph nodes. Sections were prepared from the paraffin blocks and hybridized to primary and then secondary fluorescently labeled probes. Two genes, ABL2 (the test) and GAPDH (a control house keeping gene) were studied. ABL2 was labeled green and GAPDH red. After capturing the pictures using a CCD camera, the intensity of green and red colures were measured and ratio between green/red, that demonstrate changes in ABL2 expression, were calculated.  Our data showed that expression of ABL2 protein in BL and normal lymph node was considerably different. BL had the higher expression of ABL2 protein compared to normal lymph nodes.  Like other malignancies, finding about gene expression patterns in BL seems to be helpful in future board therapeutic guidelines. Then specific inhibitors of ABL2 would be considered as new chemotherapy agents in BL treatment.
Abstract 13060: Abrogation of miR-195 Improves Function in Aged Heart by Preventing Telomere Shortening and Mitochondrial Dysfunction
Authors: Motoi Okada, HaWon Kim, Muhammad Ashraf, Jun-ichi Kawabe, Naoyuki Hasebe
Journal: Circulation (2014)

Background: Recently, we discovered a distinct microRNAs profile in young and old MSCs by microarray which led us to hypothesize that senescence-associated microRNA(miR)-195 plays a critical role in stem cell aging through telomerase reverse transcriptase (tert) deactivation and determined whether direct inhibition of miR-195 in aged myocardium restores juvenile characteristics and improves cardiac function. Methods and Results: To examine the mechanistic participation of miR-195 in cardiac aging and function, we directly injected lentivral miR-195 inhibitor into the normal mice heart through open chest surgery. Interestingly, we observed a significant telomere re-lengthening in myocardium injected with anti-miR-195 as examined by Q-FISH analysis. In addition, heart tissues treated with miR-195 inhibitor markedly restored the expression of anti-aging factors such as Tert, telomeric repeat-binding factor 2 (Trf2) and Sirt1, whereas expression of pro-aging markers including p53 and p16 were reduced. Additionally, we found that mitochondrial activity was significantly improved in miR-195 knocked down heart as examined by cytochrome c oxidase activity assay. To investigate whether abrogation of miR-195 in myocardium improves cardiac function, we performed echocardiography at 4 weeks after injection. The cardiac function was markedly improved in miR-195 knocked down myocardium as evaluated by cardiac performance index, a useful marker for heart failure (0.24±0.05 vs 0.44±0.13, p&lt;0.05, n=6), whereas there was no significant change in systolic function . Furthermore, histological analysis showed that transfection of miR-195 inhibitor markedly reduced fibrosis as well as expression of connective tissue growth factor (CTGF), a fibrogenic master switch, in the aged myocardium as compared to scramble transfected heart. Conclusions: These results demonstrate that abrogation of miR-195 improves cardiac function through restoration of anti-aging factors as well as amelioration of mitochondrial dysfunction. Suppression of miR-195 in aging myocardium is a novel therapeutic strategy for treatment against age-dependent cardiovascular diseases.
Abstract 17042: Surgery and Outcomes for Transposition of the Great Arteries among Developing World Congenital Heart Surgery Programs: a Report from the International Quality Improvement Collaborative
Authors: David N Schidlow, Kathy J Jenkins, Kimberlee Gauvreau, Ulisses A Croti, Do Thi Cam Giang, Nestor F Sandoval, Rama K Konda, Aldo Castaneda
Journal: Circulation (2014)

Objectives: Surgical care for CHD in the developing world is rapidly evolving, allowing an opportunity for survival for children with previously lethal conditions. Little information is available about such patients and their outcomes. The objectives of this study were to identify (1) patient characteristics, (2) surgical interventions, (3) institutional characteristics, and (4) risk factors for mortality among patients in the International Quality Improvement Collaborative (IQIC) undergoing surgery for transposition of the great arteries (TGA) with intact ventricular septum (IVS) and TGA with ventricular septal defect (VSD). Methods: We utilized a novel international collaborative database collected by developing world congenital heart surgical programs as part of a QI project. All TGA (IVS and VSD) cases from 2010-2012 were included. Demographic, surgical and institutional characteristics and their associations with in-hospital mortality were identified. Results: There were 559 patients at 21 centers who underwent surgery for TGA: 348 TGA/IVS and 211 TGA/VSD. TGA/IVS patients underwent arterial switch operation (ASO), 282 (81%); 2-stage ASO, 24 (7%); and atrial switch (ATS) 42, (12%). TGA/VSD patients underwent ASO, 169 (80%); 2-stage ASO, 19 (9%); and ATS, 23 (11%); all with VSD closure. In-hospital mortality ranged from 10% to 25% depending on procedure (Figure). Unadjusted mortality rates were higher among centers performing &lt;10 TGA repairs yearly (OR 3.98; 95% CI 2.08-7.60, p&lt;0.001). Among patients with TGA/IVS who underwent primary ASO, risk factors for mortality included male gender (p=0.05), weight &lt;3 kg (p=0.04), and prematurity (p=0.007). Conclusions: Infants with TGA in the developing world increasingly have access to complex surgical repairs, and the majority of such patients undergo single-stage ASO. Mortality remains substantial; however, multi-center collaborative QI efforts are likely to benefit these patients.
Infant eczema, infant sleeping problems, and mental health at 10 years of age: the prospective birth cohort study LISAplus
Authors: J. Schmitt, C.-M. Chen, C. Apfelbacher, M. Romanos, I. Lehmann, O. Herbarth, B. Schaaf, U. Kraemer, A. von Berg, H.-E. Wichmann, J. Heinrich
Journal: Allergy (2010)

To cite this article: Schmitt J, Chen C-M, Apfelbacher C, Romanos M, Lehmann I, Herbarth O, Schaaf B, Kraemer U, von Berg A, Wichmann H-E, Heinrich J, the LISA-plus Study Group. Infant eczema, infant sleeping problems, and mental health at 10 years of age: the prospective birth cohort study LISAplus. Allergy 2011; 66: 404–411. Abstract Background: Cross-sectional studies suggest an association between eczema and mental health problems, possibly modified by sleeping problems, but prospective evidence is missing. We aimed to prospectively investigate the relationship between infant eczema (within first 2 years of age), infant sleeping problems (within first 2 years of age), and the risk of mental health problems at 10 years of age. Methods: Between 1997 and 1999, a population-based birth cohort was recruited in Munich, Leipzig, Wesel, and Bad Honnef, Germany, and followed until 10 years of age. Physician-diagnosed eczema, parent-reported sleeping problems, and known environmental risk factors for atopy were regularly assessed until 10 years of age. Mental health was measured using the Strengths and Difficulties Questionnaire (parent version) at 10 years of age. We applied logistic regression modeling adjusting for environmental and lifestyle factors, allergic comorbidity, and family history of eczema. Results: From the original cohort of 3097 neonates, 1658 (54%) were followed until age 10, while 1578 (51%) were eligible for analysis. In the fully adjusted model, children with infant eczema were at increased risk of hyperactivity/inattention at 10 years of age [odds ratio (OR) 1.78; 95% confidence interval (95% CI) 1.02–3.09]. Infant eczema with concurrent sleeping problems predicted emotional problems [OR 2.63; 95% confidence interval (95% CI) 1.20–5.76] and conduct problems (OR 3.03; 95% CI 1.01–9.12) at 10 years of age. Conclusions: Infant eczema with concurrent sleeping problems appears to be a risk factor for the development of mental health problems.
Abstract P404: Validation of a Culturally Modified 24 hour Dietary Recall Questionnaire for use in Rural South Indian Populations
Authors: Asvini K Subasinghe, Amanda G Thrift, Simin Arabshahi, Oduru Suresh, Kamakshi Kartik, Kartik Kalyanram, Karen Z Walker
Journal: Circulation (2014)

Introduction: The assessment of dietary intake in rural populations can be extremely challenging because of cultural and environmental limitations.Only one other study in India has been conducted to validate a 24 hour dietary recall. The purpose of this study was to validate a three pass 24 hour dietary recall questionnaire, culturally modified for use in South Indian populations, against a series of weighed food records (WFRs). Hypothesis: We assessed the hypothesis that there will be less than 15% variance between amounts of food reported to be consumed in 24 hour dietary recalls and amounts of food weighed during WFRs. Methods: Eight life size food portion photographs of common South Indian food servings were created to aid participant recall. Nutrient intake was calculated using a food database specifically created for South Indian food items. Dietary data were compared between the two dietary assessment methods in 30 adults aged 19-85 years. WFRs were conducted in the household by a trained field worker. The amount of food served by each participant was weighed, along with any left overs not eaten. The following day, field workers administered a 24 hour recall interview to the same participant. Results: In total, 101 replicate weighed food portions were matched with estimated portions by 24 hour recall for 21 different types of food or drink. Overall, there was an 11% over-estimation by 24 hour recall compared to the WFR and a strong correlation between the two measures (r=0.93). Mean nutrient intakes obtained from each measure were not significantly different. Conclusions: The culturally specific modifications made to the 24 hour dietary recall method is valid for assessing energy, macro- and micro- nutrient intake in rural Indian populations.
Abstract 169: Brief Left Ventricular Pressure Overload Reduces Apoptosis After Myocardial Ischemia and Reperfusion
Authors: Hsien-Hao Huang, Chang-Chi Lai, Shu-Chiung Chiang, Shi-Chuan Chang, Chung-Ho Chang, Jin-Ching Lin, Cheng-Hsiung Huang
Journal: Circulation (2014)

Introduction:  Both apoptosis and necrosis contribute to cell death after myocardial ischemia and reperfusion. We previously reported brief left ventricular pressure overload decreased myocardial infarct (MI) size.   Hypothesis:  We investigated whether pressure overload reduces apoptosis and the mechanisms involved.   Methods:  MI was induced by 40-minute occlusion of the left anterior descending coronary artery followed by 3-hour reperfusion in anesthetized Sprague-Dawley rats. Brief left ventricular pressure overload was achieved by two episodes of 10-minute partial snaring of the ascending aorta, raising the systolic left ventricular pressure 50% above the baseline value. Ischemic preconditioning was elicited by two 10-minute coronary artery occlusions and 10-mintue reperfusion.   Results:  Brief left ventricular pressure overload as well as ischemic preconditioning significantly decreased MI size (p    Conclusions:  Thus, brief left ventricular pressure overload significantly reduces apoptosis. The underlying mechanisms might be related to modulation of expression of Bcl-2 and Bax, inhibition of p53, increase of Akt phosphorylation, and suppression of JNK phosphorylation.
Atrial Fibrillation is Associated with Higher Risk of Dementia and Post-Dementia Hospitalization Mortality in Individuals Without Stroke: The Atherosclerosis Risk in Communities (ARIC) Study
Authors: Lin Y. Chen, Faye Lopez, Rebecca Gottesman, Rachel Huxley, Sunil K. Agarwal, Laura Loehr, Thomas Mosley, Alvaro Alonso
Journal: Circulation (2011)

Background Atrial fibrillation (AF) is associated with higher risk of dementia in stroke patients. This association in patients without stroke is unclear. We sought to determine whether AF is assoc...
THE MANAGEMENT OF HYPERTENSION
Authors: P D WHITE
Journal: Annals of Internal Medicine (1947)

Article1 November 1947THE MANAGEMENT OF HYPERTENSIONPAUL D. WHITE, F.A.C.P.PAUL D. WHITE, F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-27-5-740 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptIn 1892, fifty-five years ago, William Osler,1 in the first edition of his noted textbook on The Principles and Practice of Medicine, had the following advice to give concerning Bright's disease, with particular reference to cases with "persistent high tension.""Treatment. Patients without local indications or in whom the condition has been accidentally discovered should so regulate their lives as to throw the least possible strain upon heart, arteries, and kidneys. A quiet life without mental worry, with gentle but not excessive exercise, and residence in an equable climate, should be recommended. In addition they should be told to keep...Bibliography1. OSLER W: The principles and practice of medicine, 1892, Young J. Pentland, Edinburgh & London. Google Scholar2. MACKENZIE J: Diseases of the heart, 3rd Edition, 1913, Henry Frowde and Hodder & Stoughton, London. Google Scholar3. BINGER C: A critique of psychotherapy in arterial hypertension, New York Academy of Medicine Bulletin, 2nd series, 1945, xxi, 610. Google Scholar4. BINGERACKERMANCOHNSCHROEDERSTEELE CANWAEHAJM: Personality in arterial hypertension. Psychosomatic Medicine Monographs, 1945, Robert Brunner, New York. Google Scholar5. ALLENSHERRILL FMJW: The treatment of arterial hypertension, Jr. Metab. Res., 1922, ii, 453. Google Scholar6. HARRISON TR: Personal communication, 1947. Google Scholar7. SELYE FL: Personal communication, 1947. Google Scholar8. CORCORANTAYLOR AR: Personal communication, 1947. Google Scholar9. KEMPNER W: Treatment of kidney disease and hypertensive vascular disease with rice diet, North Carolina Med. Jr., 1944, v, 125. Google Scholar10. ROWNTREEADSON LGAW: Bilateral lumbar sympathetic neurectomy in treatment of malignant hypertension, Jr. Am. Med. Assoc., 1925, lxxxv, 959. CrossrefGoogle Scholar11. SMITHWICK RH: Technique for splanchnic resection for hypertension: preliminary report, Surgery, 1940, vii, 1. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Boston, Massachusetts*Read at the Annual Meeting of the American College of Physicians, Chicago, April 30, 1947. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byTREATMENT OF PRIMARY HYPERTENSION IN THE OLDER AGE GROUPHypertensive Vascular Disease: Its Clinical Course, Differential Diagnosis, Pathogenesis and Treatment 1 November 1947Volume 27, Issue 5Page: 740-748KeywordsArteriesExerciseGlomerulonephritisHeartHypertensionKidneysPatients ePublished: 1 December 2008 Issue Published: 1 November 1947 PDF downloadLoading ...
Intensity of Physical Activity and Risk of Coronary Heart Disease—Reply
Authors: Janet H. Bates, Mary K. Serdula, Laura Kettel Khan, Deborah A. Jones, Caroline A. Macera, Barbara E. Ainsworth
Journal: JAMA (2001)

To the Editor: Dr Lee and colleagues found that at least 1 hour of recreational walking per week was associated with lower rates of coronary heart disease (CHD) in healthy female professionals aged 45 years and older who participated in no other vigorous activity. 1 We are concerned that health professionals and the public could easily misinterpret the appealing take-home message of Lee et al that “no pain, no gain is passe ´” and assume that 1 h/wk of any walking is sufficient for reducing the risk of chronic disease. Because the cardiovascular benefits reported in the study by Lee et al occurred in minimally active women compared with women who do no activity at all, such benefits cannot be generalized to the population as a whole. We are especially concerned because the majority of US adults report they already walk at least 1 h/wk. During 19992000, we used a national random-digit dial survey to ask 7529 adults aged 18 years and older, “In a usual week, do you walk for at least 10 minutes at a time while at work, for recreation, exercise, to get to and from places or for any other reason?” Sixty-nine percent of both male and female respondents reported walking at least 60 min/wk (95% confidence interval, 67.8%-70.4%). Based on the main finding in the study by Lee et al, these respondents might erroneously conclude that there is little additional benefit to be obtained from further increasing their activity level.
Management of Emotional Problems of Children and Adolescents.
Authors: R. M. Sinskey
Journal: Annals of Internal Medicine (1975)

complished this with but a slight increase in the size of the book.The Fifth Edition contains 1,070 text pages, the Sixth 1,114 pages.The indexes of the Fifth Edition contain 60 pages of index, the Sixth 64 pages.Although the general arrangement of the book has not been changed, there was a shift in the positions of Gastro- intestinal Drugs, Renal Drugs and Cancer Chemotherapy Drugs to more logical arrangements.Although throughout, the discussions are scholarly and show the hand of the experienced scientist and writer, the discussion of antihypertensive drugs and of the ad- renal corticoids stand out as the product of one who has spent his academic life in research in these fields.Formulas for chemical structure have been changed in the light of new information (e.g., colchicine); the treatment of acute barbiturate poisoning, new concepts of neuro-hormone action, new psychomotor stimulants, iron and other topics have been restated.An appendix on Classification According to Therapeutic Use has been dropped.As one interested in Toxicology, this reviewer would like to see an expansion of the toxicological discussions in this popular and important book, especially since toxi- cology is given so little time in the medical school cur- riculum.More descriptions of pathological changes due to overdose would be helpful to the reader.
Abstract 13302: Worsening Heart Failure During Acute Heart Failure Hospitalization: Insights from ASCEND-HF
Authors: Jacob P Kelly, Robert J Mentz, Vic Hasselblad, Justin A Ezekowitz, Paul W Armstrong, Faiez Zannad, Robert M Califf, Adrian F Hernandez, Christopher M O’Connor
Journal: Circulation (2014)

Background: After presentation with acute heart failure (AHF), some patients will worsen despite initial standard therapy during the hospitalization. This group of patients with worsening heart failure (WHF) is proposed as an endpoint in AHF trials, but limited data exist regarding the association between WHF and clinical outcomes. We assessed the characteristics and outcomes of patients with and without WHF in the ASCEND-HF trial.

Methods: WHF was defined as having at least one sign, symptom or radiologic evidence of new, persistent or WHF requiring new therapy during the index hospitalization. We assessed the relationship between WHF and the endpoints of 30-day death or HF hospitalization, 30-day death and 180-day death using logistic regression and Cox proportional hazards models. We also assessed whether there was a differential association between early (day 1-3) vs. late (day ≥4) WHF and outcomes.

Results: Of 7,141 AHF patients, 5% (N=354) experienced WHF. At baseline, patients with WHF were more often male, have a history of atrial fibrillation or diabetes, a lower blood pressure or ejection fraction, and higher creatinine or natriuretic peptide levels. WHF was associated with increased risk for 30- and 180-day outcomes even after risk adjustment ( Table ). There was no evidence of a differential association between early and late WHF with post-discharge outcomes.

Conclusions: In the setting of a large AHF trial, 5% of patients developed WHF during the index hospitalization, which was associated with marked increased risk for 30-day mortality or readmission and 180-day mortality. WHF represents an important, patient-centered outcome that should be a focus of future treatments.

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