tbuckley/cabot-search huggingface dataset:
Protective role of nitric oxide-mediated inflammatory response against lipid peroxidation in ultraviolet B-irradiated skin
Authors: S-C. Lee, J-W. Lee, J.E. Jung, H-W. Lee, S.D. Chun, I.K. Kang, Y.H. Won, Y.P. Kim
Journal: British Journal of Dermatology (2000)

Journal Article Protective role of nitric oxide‐mediated inflammatory response against lipid peroxidation in ultraviolet B‐irradiated skin Get access S‐C. Lee, S‐C. Lee Department of Dermatology, Chonnam University Medical School, 8 Hak‐dong, Dong‐ku, Kwangju 501‐757, Korea Dr Seung‐Chul Lee. E‐mail: schul@chonnam.chonnam.ac.kr Search for other works by this author on: Oxford Academic Google Scholar J‐W. Lee, J‐W. Lee Department of Dermatology, Chonnam University Medical School, 8 Hak‐dong, Dong‐ku, Kwangju 501‐757, Korea Search for other works by this author on: Oxford Academic Google Scholar J.E. Jung, J.E. Jung Department of Dermatology, Chonnam University Medical School, 8 Hak‐dong, Dong‐ku, Kwangju 501‐757, Korea Search for other works by this author on: Oxford Academic Google Scholar H‐W. Lee, H‐W. Lee Department of Dermatology, Chonnam University Medical School, 8 Hak‐dong, Dong‐ku, Kwangju 501‐757, Korea Search for other works by this author on: Oxford Academic Google Scholar S.D. Chun, S.D. Chun Department of Dermatology, Chonnam University Medical School, 8 Hak‐dong, Dong‐ku, Kwangju 501‐757, Korea Search for other works by this author on: Oxford Academic Google Scholar I.K. Kang, I.K. Kang Department of Dermatology, Chonnam University Medical School, 8 Hak‐dong, Dong‐ku, Kwangju 501‐757, Korea Search for other works by this author on: Oxford Academic Google Scholar Y.H. Won, Y.H. Won Department of Dermatology, Chonnam University Medical School, 8 Hak‐dong, Dong‐ku, Kwangju 501‐757, Korea Search for other works by this author on: Oxford Academic Google Scholar Y.P. Kim Y.P. Kim Department of Dermatology, Chonnam University Medical School, 8 Hak‐dong, Dong‐ku, Kwangju 501‐757, Korea Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 142, Issue 4, 1 April 2000, Pages 653–659, https://doi.org/10.1046/j.1365-2133.2000.03409.x Published: 01 April 2000
Eye injuries in a terrorist bombing43The opinions or assertions contained herein are the private views of the authors and are not to be construed as official or as reflecting the views of the Department of the Army or the Department of Defense.44The authors have no financial interest in any product noted in this article.
Authors: Allen B Thach, Thomas P Ward, Rodney D Hollifield, Kimberly Cockerham, Richard Birdsong, Kenyon K Kramer
Journal: Ophthalmology (2000)
Scientists grow artificial thymus cells
Authors: Abi Berger
Journal: BMJ (2000)

Engineers have designed a three dimensional grid that allows stem cells to differentiate into mature T cells ex vivo. The resulting cells are genetically similar to native thymus cells, are fully functional, and may lead to the production of T cells whose reactivity can be directed towards specific foreign antigens, potentially replacing parts of the immune system damaged by disease or chemotherapy ( Nature Biotechnology 2000;18:729-34).

The grid, used by Dr David Scadden, director of experimental haematology, and …
Knowledge about smoking and its harm among high school students
Authors: Mariana Martins Ambrozi, Liana Sousa Coelho, Suzana Erico Tanni, Lívia F.S. Baldini, Laura M.O. Caram, André Luiz Bertani, Caroline Knaut, Ilda de Godoy, Irma de Godoy
Journal: European Respiratory Journal (2012)

Introduction: Harmful effects of tobacco for human health are widely known, nevertheless, the prevalence of smoking is still increasing among adolescents. Objectives: To evaluate the behavior as well as the knowledge of high school students in Botucatu, Sao Paulo, Brazil. Methods: This work was developed with authorization of the Board of Education of the city Botucatu, in public secondary school. The students of the high school were invited to answer a questionnaire about smoking and its harms. Descriptive analysis of the data was done. Results: We obtained 292 (41.7%) valid questionnaires (age:15.9 ± 1.4years, 54.8% female). About smoking habits, 33.2% tried cigarettes at least once and 64.9% were female, 5% smoke more than 15 days/month, and 89.0% reported don9t smoke. Most students (68.5%) do not have parents or relatives who smoke indoor. 91.1% know that cigarettes cause health problems and 81.8% said that nicotine is the substance responsible for addiction. Besides of that, 62.7% are not sure about the amount of toxic substances present in the cigarette. About the use of nicotine in young people, 7.9% believe that it acts more lenient, while 19.5% believe that it acts in a powerful way, making the addiction more difficult to overcome, 24.3% say the nicotine activity is the same as in adults, and 43.2% are unsure (5,1% did not answer). About the possibility of smoking, 79.5% said that they will not smoke in the next five years and 73.3% would refuse a cigarette if their best friend offered one. 51% affirmed that they received information about the harm of smoking from teachers. Conclusion: This study noticed that, despite of all media information, young people show little knowledge about smoking and its harms.
Evaluation and Treatment of Chronic Pain.
Authors: Gerald M. Aronoff
Journal: Annals of Internal Medicine (1985)

Historical perspectives neuro-physiology diagnostic evaluation and management of chronic pain neurological and peripheral syndromes headache facial pain correlating the medical-dental relationship in digenesis of craniomandibular disorders causalgia or sympathetic dystrophy (Sudeck's atrophy) joint pains and associated disorders.
Mammary Tumors and Mammary-Gland Development in Virgin Mice of Strains C3H, RIII, and Their F&lt;sub&gt;1&lt;/sub&gt; Hybrids&lt;xref ref-type="fn" rid="FN1"&gt;2&lt;/xref&gt;
Authors: Flavia L. Richardson, Katharine P. Hummel
Journal: JNCI Journal of the National Cancer Institute (1959)

The incidence of mammary tumors was high in virgin females of strain C3H and in reciprocal F1 hybrids between strains C3H and RIII, but comparatively low in virgin females of strain RIII. The incidence of tumors differed in the reciprocal hybrids, both, however, resembling strain C3H more than strain RIII. The mean tumor age in the (C3H × RIII)F1 virgin hybrids was less than in either parental strain but more closely resembled that of C3H. The mean tumor age in the (RIII × C3H)F1 virgin hybrids was greater than that in strain C3H and not significantly different from that in strain RIII mice. The differences in incidence of mammary tumors and in mean tumor age between the two hybrid groups suggest that the agent in the milk of strains C3H and RIII differs in quality or quantity, that of C3H being the more active. The mammary glands of strain RIII virgin females usually were not well developed, whereas the glands of strain C3H usually had many lateral buds or clusters of acini along the main ducts. The mammary glands of virgin hybrids between strains C3H and RIII resembled those of strain C3H virgin females. Frequently there was better development of acini in glands of hybrids than in those of strain C3H. No differences were observed in the extent of lateral budding and acinar development in the reciprocal hybrids.
A flexible, high-density array platform for genome-wide characterization of epigenetic and transcriptional regulatory mechanisms involved in cancer
Authors: Luke Dannenberg, Leo Iniguez, Hui Liu, Heather Holster, Jacob Kitzman, Saurabh Agarwal, Tibor Rauch, Fatih Ozsolak, Jun Song, Gerd Pfeifer, Peggy Farnham, David Fisher, Roland Green, Bing Ren, Xinmin Zhang
Journal: Clinical Cancer Research (2007)

AACR Centennial Conference: Translational Cancer Medicine-- Nov 4-8, 2007; Singapore

A71 

Epigenetic mechanisms, such as DNA methylation and histone modification, and altered transcription factor binding play major roles in the development of many human diseases, most notably cancer. High-density and highly flexible DNA microarrays, derived from a unique combination of photolithography and a digital micromirror device, are now allowing researchers the opportunity to examine epigenetic events at an unprecedented scale and resolution. Phenomenon such as de novo DNA methylation of tumor suppressor gene promoters silences their expression, hence creating a gateway for uncontrolled cell division. In addition, the binding of many transcription factors becomes increased in a cancerous cell to promote the expression of genes involved in initiating carcinogenesis and metastasis. By looking on a genome-wide scale using high-density microarrays, a comprehensive picture of DNA methylation patterns, chromatin structure, and transcription factor binding can be generated to aid in the characterization of the differences between normal and cancer cells, different cancer types, the same cancer from two different individuals, and drug treatment studies. Novel platform developments, specifically the 2.16 million feature long-oligonucleotide array, have expanded the horizon of genome-wide studies for its application in elucidating epigenetic and transcriptional regulatory mechanisms involved in cancer. Cancer studies using the high-density, highly flexible microarray will be presented and discussed as well as an update on the progress on the 2.16 million feature platform.
Mercer's Orthopaedic Surgery
Authors: Sir Walter Mercer, Robert B. Duthie, George Bentley
Journal: BMJ (1944)

Introduction Musculo-Skeletal system Congenital malformations Developmental diseases of the skeleton Metabolic, hormonal and bone marrow disease Affections of the epiphyses Neuromuscular affections in children Affections of the spine in children Infections of the musculo-skeletal system Tumours of the musculo-skeletal system Arthritis and rheumatic disease Neurocirculatory disturbances of the extremities Affections of the spine The shoulder and elbow joint Affections of the wrist and hand Affections of the knee joint The foot and ankle Amputations and prosthesis Physical therapy, rehabilitation and orthotics Index
CHRONIC ULCERATIVE COLITIS: FACTORS INFLUENCING ITS RESPONSE TO SPECIFIC TREATMENT
Authors: Wyatt C. Simpson, J. Arnold Bargen
Journal: Annals of Internal Medicine (1937)

Article1 April 1937CHRONIC ULCERATIVE COLITIS: FACTORS INFLUENCING ITS RESPONSE TO SPECIFIC TREATMENTWYATT C. SIMPSON, M.D., J. ARNOLD BARGEN, M.D., F.A.C.P.WYATT C. SIMPSON, M.D.Search for more papers by this author, J. ARNOLD BARGEN, M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-10-10-1551 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptKnowledge of the condition that is known as "chronic ulcerative colitis" seems to date at least to the "bloody flux" of Sydenham, in 1669.Its bacterial etiology has been recognized only recently. Etiologic significance has generally been ascribed to the diplostreptococcus originally described by one of us.The similarity of this disease, because of its destructive character, to tuberculosis has frequently been emphasized. This fact has made it difficult to evaluate any single therapeutic agent employed in its treatment. Even though many clinicians seem to recognize its similarity to tuberculosis they frequently have not comprehended the importance of a therapeutic... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Rochester, Minnesota*Submitted for publication January 13, 1937. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 April 1937Volume 10, Issue 10Page: 1551-1555KeywordsEtiologyUlcerative colitis ePublished: 1 December 2008 Issue Published: 1 April 1937 PDF downloadLoading ...
Apoptosis profiling in diffuse large B-cell lymphomas for tailoring of therapy.
Authors: Saskia Cillessen, Corine Hess, Erik Hooijberg, Kitty Castricum, Pim Kortman, Fedor Denkers, Wim Vos, Gerrit-Jan Schuurhuis, Gert Ossenkoppele, Chris Meijer, Joost Oudejans
Journal: Clinical Cancer Research (2006)

A85   Inhibition of the apoptosis cascade is an important cause of therapy resistance in Diffuse Large B-cell Lymphomas (DLBCL). In this study we determined expression levels of apoptosis related genes in isolated and selected lymphoma cells of DLBCL biopsies. Moreover, we investigated whether expression levels of apoptosis regulating genes correlate with sensitivity to therapy and whether neutralizing the effect of apoptosis inhibitors would result in induction of apoptosis.Using multiplex quantitative RT-PCR analysis, two DLBCL groups were identified; one with relatively low expression levels of both pro- and anti-apoptotic genes and one group with high expression levels of these genes. Clinical response to chemotherapy in cases with low expression of apoptosis regulating genes was significantly more favorable than cases with high expression levels. Functional analysis in the latter DLBCL samples and DLBCL cell lines with matching expression profiles revealed high levels of spontaneous caspase 9 activity. Cell lines showing high expression levels of pro-apoptotic genes were resistant to Etoposide induced caspase 3/7 activation and apoptosis, whereas cell lines with low expression levels of these genes where sensitive to Etoposide induced caspase 9-dependent apoptosis. Inhibition of the effect of XIAP resulted in induction of caspase 9 mediated apoptosis and caspase 3/7 activation in cells with constitutive caspase 9 activity.We conclude that a subset of DLBCL demonstrate constitutive activation of the intrinsic apoptosis pathway with concomitant downstream inhibition of this pathway. In these DLBCL neutralizing the function of XIAP restores caspase 9 dependent apoptosis. Thus, inhibition of downstream apoptosis inhibitory proteins may be an important alternative therapy for chemotherapy refractory DLBCL and apoptosis profiling can predict the response to apoptosis sensitizing therapy.
Abstract 16947: A Meta-Synthesis on Usefulness of Stress Reduction with Meditation in the Prevention and Treatment of Cardiovascular Disease
Authors: Catherine Aquino-Russell, Amy Ruff, Robert H Schneider
Journal: Circulation (2014)

Introduction: Epidemiological research has documented that psychosocial stress is a major risk factor for atherosclerotic cardiovascular disease (CVD). In providing effective health education to patients with CVD, nurses and other health professionals require evidence-based information on behavioral methods to reduce stress for primary and secondary prevention of CVD. Previously published trials suggest that selected stress reduction methods, including meditation may modify CVD risk factors, quality of life, morbidity and mortality. Hypothesis: Stress reduction with meditation may contribute to the management of psychosocial stress, hypertension, metabolic syndrome, chronic CVD, nonfatal/fatal CVD clinical events and associated health care costs. Methods: We performed a meta-synthesis (qualitative review) of published biomedical literature for randomized controlled trials, meta-analyses and professional guidelines on the effects of meditation on CVD and its risk factors. Results: The two most widely studied stress reduction - meditation approaches in CVD were the Transcendental Meditation (TM) technique and mindfulness meditation There were 11 RCTs, two meta-analyses and one American Heart Association scientific statement on TM and blood pressure that suggest TM is clinically useful in lowering high BP, short and long-term, in diverse populations. Other risk factors showing beneficial responses to TM were anxiety, insulin resistance, smoking and surrogate markers for CVD. RCTs and meta-analyses report significant risk reductions for myocardial infarction, stroke and mortality over 5-8 years. In patients with CVD, mindfulness meditation was associated with beneficial psychological effects; however, in meta-analyses of physical parameters of CVD, effects were not yet well-established. Conclusion: Available evidence suggests that meditation may be useful in the behavioral interventions for cardiovascular health and quality of life. Both Transcendental Meditation and mindfulness meditation practices show beneficial effects on psychosocial stress factors. Substantial evidence indicates that TM practice is associated with reductions in hypertension, other CVD risk factors, and rates of CVD morbidity and mortality.
Longitudinal surveillance for meningitis by Acinetobacter in a large urban setting in Brazil
Authors: T. Coelho-Souza, J.N. Reis, N. Martins, I.S. Martins, A.O. Menezes, M.G. Reis, N.O. Silva, R.C.S. Dias, L.W. Riley, B.M. Moreira
Journal: Clinical Microbiology and Infection (2013)
Abstract 3687: Analgesic effects of capsazepine on a mouse model of bone cancer pain
Authors: Matthew D. Balenko, Eric Seidlitz, Gurmit Singh
Journal: Cancer Research (2014)

Abstract Breast cancer has the highest incidence rate in women, accounting for more than 22% of all cancers and possessing a strong disposition to metastasize to bone. Discovered in 70% of advanced breast cancer patients and over 90% prevalence in patients who die from breast cancer, the affinity of this disease to metastasize bone has become overwhelming. These skeletal metastases become a significant cause of morbidity and mortality in patients with the primary symptom being pain. Pain is a major concern in determining a patient's quality of life and there have been many attempts to understand and control bone pain with little success. Capsazepine was identified during a high throughput screen to be a potent inhibitor of breast cancer cell-mediated glutamate release, a neurotransmitter with known associations in both neural communication and pain. This drug also has antagonistic effects on transient receptor potential vanilloid type 1 (TRPV-1) receptors which act as key players in both heat and vanilloid-induced nociception. Studies have shown that glutamate plays a role in bone cancer pain, with an excess in free glutamate able to cause pain either directly through excitotoxic pathways or indirectly though the dysregulation of osteoclasts and osteoblasts, causing bone dysregulation. TRPV-1 receptors have also has been implicated in the mechanisms of bone cancer pain, as osteoclasts release protons during bone remodeling which can elicit a TRPV-1-related nociceptive response from neurons in the surrounding periosteum. These findings suggest that Capsazepine may provide a powerful multi-pronged approach to treating cancer pain. A model of breast cancer-induced bone pain has been established using human MDA-MB-231 breast adenocarcinoma cells injected into the femurs of BALB/c nude mice. Behavioural tests are then preformed using the dynamic plantar aesthesiometer (DPA) and the dynamic weight bearing (DWB) devices on the affected limb for both movement-evoked and spontaneous pain-related behaviours. Using Capsazepine, delivered intraperitoneally via mini-osmotic drug pumps (5kg/mg and 10kg/mg), we demonstrate a dose-dependent attenuation of pain behaviours in vivo. While confirming tumour presence using immunohistochemistry (IHC) we show that TRPV-1 and glutamate play an important role in the onset and severity of bone cancer pain. The use of Capsazepine was able to attenuate these pain-related behaviours without the side effects of common analgesics. (This work is supported by the Canadian Institutes of Health Research (CIHR)) Citation Format: Matthew D. Balenko, Eric Seidlitz, Gurmit Singh. Analgesic effects of capsazepine on a mouse model of bone cancer pain. [abstract]. In: Proceedings of the 105th Annual Meeting of the American Association for Cancer Research; 2014 Apr 5-9; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2014;74(19 Suppl):Abstract nr 3687. doi:10.1158/1538-7445.AM2014-3687
Reteplase in Acute Myocardial Infarction
Authors: Anthony J. Busti, Kristen S. Marshall, Justin S. Hooper
Journal: JAMA (2004)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2022 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
In critically ill adults, transfusion of fresh vs standard-issue red blood cells did not differ for 90-d mortality
Authors: Michael Jacka, Susan Nahirniak‡
Journal: Annals of Internal Medicine (2015)

Source Citation Lacroix J, Hébert PC, Fergusson DA, et al; ABLE Investigators; Canadian Critical Care Trials Group. Age of transfused blood in critically ill adults. N Engl J Med. 2015;372:1410-8. 25853745
Ventilation/Blood Flow and Gas Exchange.
Authors: John B. West
Journal: Annals of Internal Medicine (1978)

Introduction Oxygen transport from air to tissues Inequality of blood flow and ventilation in the normal lung Ventilation-perfusion ratio inequality and regional gas exchange Ventilation-perfusion ratio inequality and overall gas exchange Methods of measuring ventilation-perfusion ration inequality Distributions of ventilation-perfusion ratios Appendixes: How to talk the Va/Q language How to draw a Va/Q line Suggestions for further reading References Index
Techniques for the replication of skin surfaces.
Authors: I.E. BARNES
Journal: British Journal of Dermatology (1973)

Journal Article Techniques for the replication of skin surfaces: A NEW METHOD Get access I.E. BARNES I.E. BARNES Dental Department, University College Hospital Medical School, University of London Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 89, Issue 3, 1 September 1973, Pages 277–283, https://doi.org/10.1111/j.1365-2133.1973.tb02974.x Published: 01 September 1973 Article history Accepted: 24 January 1973 Published: 01 September 1973
A novel mutation in the NADH-cytochrome b5 reductase gene of a Chinese patient with recessive congenital methemoglobinemia
Authors: Yao Wang, Yu-Shui Wu, Pei-Zhen Zheng, Wen-Xi Yang, Guo-An Fang, Yu-Chai Tang, Fei Xie, Feng-Hua Lan, Zhong-Yong Zhu
Journal: Blood (2000)