tbuckley/cabot-search huggingface dataset:
Methylsulfonyl metabolites of PCBs and DDE in human milk in Sweden, 1972-1992.
Authors: K Norén, A Lundén, E Pettersson, A Bergman
Journal: Environmental Health Perspectives (1996)

A multicomponent method used for analysis of organochlorine pesticides, polychlorinated biphenyls (PCBs), naphthalenes, dibenzo-p-dioxins, and dibenzofurans was adapted for the analysis of methylsulfonyl metabolites of chlorinated biphenyls (MeSO2-CBs) and of p,p'-DDE (MeSO2-DDE) in human milk. The extraction and initial purification was made by liquid-gel partitioning. Additional purification and separation steps were achieved by adsorption and gel permeation chromatography. The mean recoveries of 23 MeSO2-CBs and MeSO2-DDE standards, added to the milk before extraction, were 80-97%. Human milk sampled in Stockholm during 1972, 1976, 1980, 1984/85, 1990, 1991, and 1992 was analyzed by GC-MS. During the time course studied, the concentrations of MeSO2-CBs decreased from approximately 9 to 2 ng/g lipids and of MeSO2-DDE from 5 to 0.4 ng/g lipids. The concentrations of MeSO2-CBs and MeSO2-DDE correlated to the levels of total PCB and p,p'-DDE, respectively. 3-MeSO2-DDE was the major isomer of the aryl methyl sulfones studied in the milk. PCB methyl sulfones with five and six chlorine atoms in the molecule were predominant among the PCB methyl sulfones Generally, the concentrations of 4-MeSO2-CBs were higher than the corresponding 3-MeSO2-CB compound. The major MeSO2-CBs in the milk were 4-MeSO2-2,5,2',3',4'-pentaCB (4-87) and 4-MeSO2-2,3,6,2',4',5'-hexaCB (4-149).
Consensus in Patient-Therapist Interactions
Authors: Maarten Dormaar, Chantal I.M. Dijkman, Marten W. de Vries
Journal: Psychotherapy and Psychosomatics (1989)

This paper discusses consensus between patient and therapist as a measure of the quality of the psychotherapeutic relationship. Consensus is defined by two interpersonal concepts, agreement and understanding, and two intrapersonal concepts, congruency and experienced consensus. 162 patients and their therapists in a Dutch Center for Comprehensive Mental Health Care were rated on the degree of consensus. Two patient self-report outcome measures and one reported by the therapist were related to consensus. The three consensus measures that predicted outcome after 6 months were understanding by the therapist as well as agreement and experienced consensus by the patient. This result suggests that a complementary patient-therapist relationship favors a good psychotherapy result. The instruments in this paper provide a means to measure consensus during the process of psychotherapy. This is a feasible way to both monitor progress and improve the chances of a successful outcome.
1143 SUSTAINED VIROLOGICAL RESPONSE RATES ARE HIGHER AMONG HEPATITIS C VIRUS Gl PATIENTS WITH HIGH EXPRESSION OF IFN STIMULATED GENES
Authors: C.M. Calderón-Rodríguez, J.A. Mata-Marín, J.E. Muñoz-Medina, M.L. Martínez-Rodríguez, B. Manjarrez-Tellez, A. Chaparro-Sánchez, J.E. Gaytán-Martínez
Journal: Journal of Hepatology (2011)
The currency of personal medical data
Authors: T. Greenhalgh
Journal: BMJ (2009)

During the US presidential election campaign John McCain made 1200 pages of his medical records from the Mayo Clinic available to journalists. He did this to prove that his recurrent skin cancers were under control and that despite two bayonet wounds and torture scars from five years as a prisoner of war he was psychologically unscathed, “considerably younger than his chronological age,” and fit to lead America. Barack Obama parried with a one page statement from his physician saying that he had no significant medical history, a blood pressure of 90/60 mm Hg, a pulse of …
A first in human, dose escalation trial of MSC2363318A – a dual p70S6K/Akt inhibitor, for patients with advanced malignancies
Authors: A.M. Tsimberidou, C. Verschraegen, G. Heestand, R. Kaleta, J. Scheuenpflug, B. Huck, A. Weise, R. Kurzrock
Journal: Annals of Oncology (2015)
Human T-cell lines with well-defined T-cell receptor gene rearrangements as controls for the BIOMED-2 multiplex polymerase chain reaction tubes
Authors: Y Sandberg, B Verhaaf, E J van Gastel-Mol, I L M Wolvers-Tettero, J de Vos, R A F MacLeod, J G Noordzij, W A Dik, J J M van Dongen, A W Langerak
Journal: Leukemia (2006)
OXYGEN CONSUMPTION IN THE PSYCHOSES OF THE SENIUM
Authors: D. EWEN CAMERON, HAROLD E. HIMWICH, S. R. ROSEN, JOSEPH FAZEKAS
Journal: American Journal of Psychiatry (1940)

1. Twenty-three patients suffering from psychoses occurring within the senium were investigated with regard to their cerebral oxygen consumption. 2. The arterial oxygen was low (16.31 vol. per cent). It is suggested that this is in part due to the emphysema and increase in residual air frequently found in aged persons; it may be due in part to failure of diffusion from the capillary alveolar walls. 3. The oxygen-carrying power of the blood was reduced, as indicated by an erythrocyte count of 4,220,000 and a hemoglobin of 87 per cent (Sahli). 4. The arm to carotid circulation time was increased (25.6 seconds). 5. If the cerebral circulation time is reduced, as we have shown the arm to carotid circulation time to be, then the normal cerebral A-V difference in our patients would indicate a diminished oxygen consumption by the cerebral tissues.
ETHER INTRAMUSCULARLY FOR THE RELIEF OF HICCUP
Authors: Charles L. Gibson
Journal: JAMA (1923)

For the last two years, all cases of hiccup coming under my observation, more particularly after operation, have been treated by the intramuscular injection of 25 or 30 minims of ether. Dr. Allen M. Thomas of New York called my attention to its use in children for stopping the paroxysms of whooping cough, and it occurred to him that it might likewise be useful in the paroxysm of hiccup. If the original dose is not immediately successful, it is repeated one or more times at several hours' interval. Its administration is not painful, and has never been attended with unpleasant circumstances. The first patient on whom I tried it was an elderly and feeble man who, shortly after a gastro-enterostomy for pyloric stenosis, developed hiccup of moderate severity but of great persistency. The other time-honored remedies had no effect. After the first administration of ether, the hiccups diminished in severity
A prospective, community-based evaluation of liver enzymes in individuals with hepatitis C after drug use
Authors: Thomas V. Inglesby, Rudra Rai, Jacquie Astemborski, Leslie Gruskin, Kenrad E. Nelson, David Vlahov, David L. Thomas
Journal: Hepatology (1999)

Serum alanine transaminase (ALT) levels are used to select hepatitis C virus (HCV)–infected patients for treatment and liver biopsy. However, the natural history of these measurements is poorly understood. To examine the hypothesis that ALT levels vary over time in HCV–infected patients, serial serum ALT levels were prospectively measured in a cohort of 1,235 persons with a history of prior illicit drug use. Over 25 months of follow–up, there was a median of four evaluations per patient. ALT values were higher in 1,164 (94%) HCV–infected individuals than in 71 (6%) HCV–uninfected individuals. The remainder of the analysis focused on these HCV–infected individuals, 647 (62%) of whom had normal ALT values at their initial visit. However, 323 (49%) of these had at least one elevated ALT over the next 25 months. Of the 395 patients whose ALT was initially abnormal, 332 (84%) had at least one normal value over the next 25 months. Overall, among individuals with four or more visits, ALT values were persistently normal in 42%, persistently elevated in 15%, and intermittently elevated in 43%. Because serum ALT levels have high visit–to–visit variability, single assessments should not be used to manage HCV–infected individuals. Further investigation is needed to ascertain the correlation of serial ALT trends with important disease outcomes.
FDA is told to ease restrictions on morning after pill
Authors: J. H. Tanne
Journal: BMJ (2009)

The US Food and Drug Administration must make the morning after pill Plan B available over the counter to women aged 17 or older, not just those aged 18 or older, within 30 days. It must also reconsider whether girls and women younger than 17 can obtain emergency contraception.

The 23 March ruling came in a case brought by the Center for Reproductive Rights, which is based in New York but which works to advance reproductive rights worldwide, and was decided by Judge Edward Korman of the US District Court for the …
Leukotrienes and Other Products of the 5-Lipoxygenase Pathway
Authors: R A Lewis, K F Austen, R J Soberman
Journal: New England Journal of Medicine (1990)

THE slow-reacting substance of anaphylaxis was recognized as a discrete biologic entity 1 , 2 three to four decades before it was chemically defined as three specific cysteinyl leukotriene products of the 5-lipoxygenase pathway.3 4 5 6 7 In the interim, it was hypothesized that this moiety might function as a proinflammatory mediator of bronchoconstriction and vasopermeability in diseases of immediate hypersensitivity.8 9 10 11 Since the chemical characterization of the slow-reacting substance of anaphylaxis as several cysteinyl leukotrienes and the identification and biochemical assessment of the enzymes in the 5-lipoxygenase pathway (Fig. 1 and Glossary), the products of this pathway have been implicated in a much broader variety of functions . . .
Ireland needs healthier airways and lungs: the evidence (INHALE)
Authors: N. Brennan, T.M. O'Connor
Journal: European Respiratory Journal (2004)

To the Editor: 

We would like to congratulate the European Respiratory Society on the publication of the European Lung White Book . Here, on the western periphery of Europe, we have felt that our Irish Health Service is not fully aware of the importance of lung diseases and the resources necessary to deal with them. Accordingly, we have recently published a report entitled “Ireland needs healthier airways …
Need for liver biopsy in alcoholic liver disease.
Authors: G Bird, R Williams
Journal: BMJ (1991)

with her strong need to express love-two very different things.Among all deaths the sudden traumatic death of a young person tends to have the greatest impact on the bereaved, who therefore need particularly careful handling.Bereaved people should always be offered the chance to see the body, and generally this should be encouraged.It is an important part of accepting the reality and often helps to dispel the imagined disfigurement.Fact is generally preferable to fantasy, and what right have we to protect bereaved people?The deceased is their relative, and their feelings will tell them what they need to do.We are perhaps just protecting ourselves and hindering them in the process.Seeing the body is also a chance for the people to inspect, touch, hold, kiss, or say goodbye to their loved one.Staff should give permission for these free expressions, as well as allow the chance for bereaved people to be left alone with the body.2Some may need several visits.Sheila Awooner-Renner was unnecessarily (and cruelly) kept waiting, and when she eventually got to her son she felt inhibited and was watched.There was no need to wait for the coroner's officer.How are we to avoid this well meaning but inappropriate handling of distressed relatives?The hospice movement has led the way, but the acute sector needs a system for coping 24 hours a day.Accident and emergency departments are increasingly recognising the needs of bereaved people, regarding them as unofficial patients (often led by nurses).As well as the senior accident and emergency staff hospital chaplains, social workers,
Testosterone and Resistance Training in AIDS
Authors: Steven K. Grinspoon
Journal: Annals of Internal Medicine (2001)

Letters3 July 2001Testosterone and Resistance Training in AIDSSteven K. Grinspoon, MDSteven K. Grinspoon, MDHarvard Medical School; Boston, MA 02108 (Grinspoon)Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-135-1-200107030-00028 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail IN RESPONSE:We agree with Dr. Kamel that our data demonstrate a significant effect of supraphysiologic testosterone on muscle mass and strength in eugonadal men with AIDS wasting. The use of testosterone may therefore be considered to reverse sarcopenia in this population. However, we also agree that the long-term safety of supraphysiologic testosterone is unknown in this population. Although our data do not show adverse effects on prostate-specific antigen and hematocrit levels, the study was short and the longer-term safety effects remain unknown. Furthermore, our data do suggest a decrease in high-density lipoprotein cholesterol level, which may adversely affect such ... Author, Article, and Disclosure InformationAuthors: Steven K. Grinspoon, MDAffiliations: Harvard Medical School; Boston, MA 02108 (Grinspoon) PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoEffects of Testosterone and Progressive Resistance Training in Eugonadal Men with AIDS Wasting Steven Grinspoon , Colleen Corcoran , Kristin Parlman , Madeline Costello , Dan Rosenthal , Ellen Anderson , Takara Stanley , David Schoenfeld , Belton Burrows , Doug Hayden , Nesli Basgoz , and Anne Klibanski Testosterone and Resistance Training in AIDS Hosam K. Kamel Metrics 3 July 2001Volume 135, Issue 1 Page: 65 Keywords AIDS Antigens Hematocrit High density lipoprotein cholesterol Long-term care Muscles Safety Safety studies Testosterone ePublished: 3 July 2001 Issue Published: 3 July 2001 Copyright & PermissionsCopyright © 2001 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
We the People of the United States— Are We Sheep?
Authors: James Z. Appel
Journal: JAMA (1965)

The other day I was browsing through a bookstore and idly glanced at the back of a book lying on a shelf. I turned the book over and noted the title,<i>The Heart of Man</i>by Erich Fromm. I have enjoyed Fromm in the past and the quotation on the back coverleaf of the book interested me. So, I opened the book and read the opening of the first chapter: There are many who believe that men are sheep; there are others who believe that men are wolves. Both sides can muster good arguments for their positions. Those who propose that men are sheep have only to point to the fact that men are easily influenced to do what they are told, even if it is harmful to themselves; that they have followed their leaders into wars which brought them nothing but destruction; that they have believed any kind of
Whither the Chronic Disease Hospital?-Reply
Authors: Asa P. Ruskin
Journal: JAMA (1976)

<h3>In Reply.—</h3> I certainly am in wholehearted agreement with Dr Lee that the medical rehabilitation institute or chronic disease hospital and the skilled nursing facility both have separate roles, and it is not my intention to suggest that all skilled nursing facilities be replaced by chronic disease hospitals, as perhaps only two or three of the latter designation are really necessary for the entire state. I believe that we should emphasize and expose the "catch 22," which we both know is currently crippling the running of our respective skilled nursing facilities, the truth being that the nursing facility code requires a high level of rehabilitation care that is supervised by one arm of the state health department, while the financial reimbursement necessary to provide such care is not forthcoming. I am certain that the originators of the skilled nursing facility concept were well-motivated but unable to convey to those who
Innate immune control of EBV-infected B cells by invariant natural killer T cells
Authors: Brian K. Chung, Kevin Tsai, Lenka L. Allan, Dong Jun Zheng, Johnny C. Nie, Catherine M. Biggs, Mohammad R. Hasan, Frederick K. Kozak, Peter van den Elzen, John J. Priatel, Rusung Tan
Journal: Blood (2013)
Treatment of postrenal transplantation lymphoproliferative disease manifesting as plasmacytoma with nonmyeloablative hematopoietic stem cell transplantation from the same kidney donor
Authors: W.Y. Au, A.K.W. Lie, E.C. Chan, A. Pang, S.K. Ma, C. Choy, Y.L. Kwong
Journal: American Journal of Hematology (2003)

Abstract Posttransplantation lymphoproliferative disease (PTLD) presenting as an Epstein‐Barr‐virus (EBV)–related nasal plasmacytoma developed in a renal‐allograft recipient 13 years after transplantation. Systemic dissemination occurred despite immunosuppression withdrawal, surgery, irradiation, and chemotherapy. A nonmyeloablative hematopoietic‐stem‐cell‐transplantation (HSCT) with peripheral blood HSC from the kidney donor was performed. With the onset of graft‐versus‐host disease, resolution of the systemic disease was demonstrated clinically and molecularly by serial quantification of plasma EBV‐DNA. Isolated relapse occurred in the central nervous system (CNS), a known tumour sanctuary site, ultimately leading to death. Nonmyeloablative HSCT might be considered a cellular therapy for PTLD, but possible CNS relapse must be effectively tackled. Am. J. Hematol. 74:283–286, 2003. © 2003 Wiley‐Liss, Inc.
Abstract 2687: Development of a new, highly sensitive assay for circulating tumor cell (CTC) detection based on the CellSearch® CTC Profile Kit enrichment and laser scanning cytometry analysis
Authors: Vladislava O. Melnikova, Wen Liu, Yujian Zhang, David S. Hong, Darren W. Davis
Journal: Cancer Research (2010)

Abstract The presence of CTCs in the peripheral blood, as detected by the FDA-approved CellSearch® CTC Kit, is associated with decreased overall and progression free survival in patients with metastatic breast, prostate and colorectal cancers. In addition to CTC enumeration, CellSearch® CTC Kit provides a unique tool for CTC biomarker analysis in cancers of epithelial origin (CD45—, EpCAM+, and cytokeratins (CK) 8,18-positive and/or 19-positive). Considerable cell loss is suspected to occur at many of the automated steps of the CellSearch® CTC process, resulting in undermined recovery of CTCs. Herein, we demonstrate an improved, highly sensitive approach for CTC enumeration, which is based on the CellSearch® CTC Profile Kit and immunofluorescent analysis using LSC. The initial blood processing was conducted using the CellSearch® CTC Profile Kit from Veridex and the CellTracks® AutoPrep® system, which allowed recovery of the EpCAM+ cells directly from the instrument. Next, EpCAM+ cell population was subjected to manual immunofluorescent labeling with antibodies against CK and CD45, and CTCs were enumerated by LSC, based on the standard CellSearch® CTC criteria. When we compared this new method to standard CTC enumeration in patients with various cancer types including head and neck, renal cell, basal cell, prostate, non-small cell lung, sebaceous gland and ovarian cancers, we consistently detected higher CTC counts in samples analyzed with the new method. Indeed, 88% of patients (79 out of 90) were CTC-negative based on the standard analysis, while only 37% of patients were CTC-negative based on the CTC Profile Kit/LSC data. We next conducted a side-by-side comparison of the two techniques in patients with hepatocellular carcinoma (HCC, EpCAM-low) and prostate cancer (EpCAM+). CTC Profile Kit/LSC method demonstrated up to a 470% increased CTC recovery in the prostate cancer samples. Remarkably, it also allowed isolation of CTCs from the CTC-negative (as detected by the standard kit) HCC and prostate cancer samples. Finally, the new CTC enumeration method consistently yielded higher CTC counts in patients enrolled in a Phase I clinical trial of Bevacizumab and Cediranib. Importantly, our preliminary analysis indicated that changes in CTC counts from baseline to 24 h post-therapy, as measured by the new method, may correlate with changes in tumor size. In conclusion, we developed a new CellSearch® CTC Profile Kit/LSC-based method that offers higher sensitivity of CTC recovery and thus provides a broader capability for downstream molecular characterization. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 101st Annual Meeting of the American Association for Cancer Research; 2010 Apr 17-21; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2010;70(8 Suppl):Abstract nr 2687.
THE SENSITIZATION OF RATS BY ALLOGRAFTS TRANSPLANTED TO ALYMPHATIC PEDICLES OF SKIN
Authors: N. L. Tilney, J. L. Gowans
Journal: The Journal of Experimental Medicine (1971)

Pedicles of skin which lacked a lymphatic drainage were raised on the backs of rats in order to study the importance of afferent lymphatics in sensitization by skin allografts. Although allografts transplanted to the alymphatic pedicles enjoyed a prolonged survival, they contracted progressively from about 3 wk after transplantation and were reduced eventually to small scars. In contrast, autografts survived unchanged in size for the life-span of the pedicles which carried them. The slow contracture of the allografts was associated with sensitization of the host because test allografts applied orthotopically were destroyed with a second-set tempo. No regeneration of lymphatics from the long-standing pedicles could be demonstrated, and it was concluded that sensitization had occurred eventually through the blood, presumably by the process of peripheral sensitization. Allografts on skin pedicles could be destroyed rapidly by active or adoptive immunization, so it is probable that the level of sensitization to which they themselves gave rise was a low one. Although it is not disputed that afferent lymphatics are essential for the rapid destruction of skin allografts, it is clear that the absence of a lymphatic supply does not permanently exempt them from immunological attack in the rat.
Effect of a Geriatric Consultation Team on Functional Status of Elderly Hospitalized Patients
Authors: Laura J. McVey
Journal: Annals of Internal Medicine (1989)

Study Objective: To evaluate the impact of a geriatric consultation team on the functional status of hospitalized elderly patients. Design: Randomized controlled clinical trial. Setting: University-affiliated referral Veterans Administration Medical Center. Patients: One hundred and seventy-eight hospitalized elderly men 75 years or older admitted to medical, surgical, and psychiatry services, but excluding patients admitted to intensive care units. Intervention: Eighty-eight intervention group patients received multidimensional evaluation by an interdisciplinary geriatric consultation team composed of a faculty geriatrician, geriatrics fellow, geriatric clinical nurse specialist, and a social worker trained in geriatrics. Results of the evaluation, including problem identification and recommendations, were given to the patients' physicians. Ninety control group patients received only usual care. Measurements and Main Results: Intervention and control groups were comparable initially. The major outcome variable was the Index of Independence in the Activities of Daily Living (ADL) (Katz). Thirty-nine percent of the total study population was functionally independent on admission, 27% required assistance with one to three ADL, 22% required assistance with four to six ADL, and 12% were completely dependent. Many patients remained unchanged from admission to discharge: intervention group, 38%; control group, 39%. In the intervention group, 34% improved and 28% declined; in the control group, 26% improved and 36% declined. Although these changes reflected a trend toward greater improvement in the intervention group, the results were not statistically significant. Conclusions: Among elderly patients entering an acute-care hospital, approximately 60% had some degree of, and one third had serious functional disability. Such patients are at risk for further decline during hospitalization. A geriatric consultation team was unable to alter the degree of functional decline. Geriatric units or consultation teams may have to offer direct preventive or restorative services in addition to advice if improvements are to be made.