OBSERVATIONS ON THE NATURE OF THE AUTOANTIBODIES IN A CASE OF ACQUIRED HEMOLYTIC ANEMIA
Authors: A S WIENER, E RUSSOW
Journal: Annals of Internal Medicine (1957)

Article1 July 1957OBSERVATIONS ON THE NATURE OF THE AUTOANTIBODIES IN A CASE OF ACQUIRED HEMOLYTIC ANEMIAALEXANDER S. WIENER, M.D., F.A.C.P., EVE B. GORDON, ERICH RUSSOW, M.D.ALEXANDER S. WIENER, M.D., F.A.C.P.Search for more papers by this author, EVE B. GORDONSearch for more papers by this author, ERICH RUSSOW, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-47-1-1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptOne of the results of the discovery of the Rh factor was the development of new methods of demonstrating red cell antibodies. In addition to the classic methods of iso-agglutination and iso-hemolysis, the immuno-hematologist now has at his disposal the blocking test,1the conglutination test,2the antiglobulin test,3, 4and the proteolytic enzyme test.5, 6Accordingly, when problems of an immunohematologic nature are encountered, it is rare indeed that the antibody responsible cannot be demonstrated by one or more of the available methods. As a result of investigations carried out using these new technics, a good deal of light has...Bibliography1. Wiener AS: A new test (blocking test) for Rh sensitization, Proc. Soc. Exper. Biol. and Med. 56: 173, 1944. CrossrefGoogle Scholar2. Wiener AS: Conglutination test for Rh sensitization, J. Lab. and Clin. Med. 30: 662, 1945. Google Scholar3. CoombsMourantRace RRAERR: A new test for the detection of weak and "incomplete" Rh agglutinins, Brit. J. Exper. Path. 26: 255, 1945. MedlineGoogle Scholar4. WienerGordon ASEB: Quantitative test for antibody globulin coating human red cells, Am. J. Clin. Path. 23: 429, 1953. CrossrefMedlineGoogle Scholar5. MortonPickles JAMM: The use of trypsin in the detection of incomplete anti-Rh antibodies, Nature, London 159: 779, 1947. CrossrefMedlineGoogle Scholar6. WienerKatz ASL: Studies on the use of enzyme treated red cells in tests for Rh sensitization, J. Immunol. 66: 51, 1951. MedlineGoogle Scholar7. WienerGordonGallop ASEBC: Studies on autoantibodies in human sera, J. Immunol. 71: 58, 1953. MedlineGoogle Scholar8. WienerUngerCohenFeldman ASLJLJ: Type-specific cold auto-antibodies as a cause of acquired hemolytic anemia and hemolytic transfusion reactions. Biologic test with bovine red cells, Ann. Int. Med. 44: 221, 1956. LinkGoogle Scholar9. Wiener AS: Origin of naturally occurring hemagglutinins and hemolysins: a review, J. Immunol. 66: 287, 1951. MedlineGoogle Scholar10. Wiener AS: The solution of certain fundamental immunological problems by studies on Rh sensitization, Ann. Allergy 10: 535, 1952. MedlineGoogle Scholar11. Felton LD: The significance of antigen in animal tissue, J. Immunol. 62: 107, 1949. Google Scholar12. BurnetFenner FMF: The production of antibodies, 1949, Macmillan Co., Melbourne, Australia. Google Scholar13. Wiener AS: Autoantibody formation and disease, Brit. M. J. 2: 163, 1950. CrossrefGoogle Scholar14. WeinerBatteyCleghornMorsonMegnell WDATEEGMJ: Serological findings in a case of haemolytic anemia, with some general observations on the pathogenesis of this syndrome, Brit. M. J. 2: 125, 1953. CrossrefMedlineGoogle Scholar15. Van Loghemvan der Hart JJM: Varieties of specific autoantibodies in acquired haemolytic anemia, Vox Sang. 4: 2, 1954. Google Scholar16. Dacie JV: The hemolytic anemias, 1954, Grune & Stratton, New York. Google Scholar17. Wiener AS: Rh-Hr blood types, 1954, Grune & Stratton, New York, p. 726. Google Scholar18. Rosenfield R: Personal communication. Google Scholar19. CallenderRace STRR: A serological and genetical study of multiple antibodies formed in response to blood transfusion by a patient with lupus erythematosus diffusus, Ann. Eugenics 13: 102, 1946. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: *Received for publication March 6, 1957.From the Serological Laboratory of the Office of the Chief Medical Examiner of New York City, and the Evangelical Deaconess Hospital, Brooklyn, N. Y.Requests for reprints should be addressed to Alexander S. Wiener, M.D., 64 Rutland Road, Brooklyn 25, N. Y. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byBlood Transfusion in Autoimmune Hemolytic AnemiasTransfusing the Patient with Autoimmune Hemolytic AnemiaThe reactivity of red blood cell membrane glycophorin with “cold-reacting” antibodiesENZYMATIC AND NONENZYMATIC ALTERATIONS OF ERYTHROCYTE SURFACE ANTIGENSProbleme der autoimmunh�molytischen An�mienImmunological Specificity of Eluates from “Coombs Positive” ErythrocytesHEMOLYTIC MECHANISMS* 1 July 1957Volume 47, Issue 1Page: 1-9KeywordsAnemiaAntibodiesAutoantibodiesEnzymesHemolytic anemiaLymphomaPneumoniaResearch laboratoriesTrypanosomiasis ePublished: 1 December 2008 Issue Published: 1 July 1957 Copyright & PermissionsCopyright ©, 1957, by The American College of PhysiciansPDF downloadLoading ...