tbuckley/cabot-search huggingface dataset:
ANATOMIC POINTS IN ABDOMINAL AND PELVIC SURGERY.
Authors: C. E. RUTH
Journal: JAMA (1898)

I make no claim to know anything which no one else has knowledge of, but have observed a few things in my surgical work which proved to be of enough importance to me that I became anxious that others might appreciate them more, and possibly save themselves and unfortunate patients trouble, suffering or life. We often meet with adhesions between peritoneal surfaces, the legitimate ultimate result of peritoneal inflammations of all kinds, so numerous and extensive that all semblance to normal organs and landmarks is destroyed. These adhesions are always primarily conservative, but may lead to secondary grave complications. They may be so strong as to readily bear the patient's weight. The attenuation of these adhesions becomes possible when the inflammation causing it was traumatic, small in area, and a more or less constant tension was maintained thereafter. No man should for a moment think seriously of engaging in abdominal
Simultaneous primary infection with varicella zoster and Epstein-Barr viruses.
Authors: J Billheden, B Hill, P Juto, B Settergren, B Trollfors
Journal: BMJ (1987)

Une observation rare: enfant de 6 ans, atteint de mononucleose infectieuse due au virus Epstein-Barr, presentant en meme temps une infection par le virus de la varicelle
Does late reperfusion therapy for myocardial infarction improve left ventricular function? preliminary results of the TAMI-6 randomized, controlled trial
Authors: Eric J. Topol, Stephen G. Ellis, Thomas C. Wall, Barry S. George, Michel Vandormael, Cindy L. Grines, Mark L. Sanz, Maryann O'Brien, Robert M. Califf
Journal: Journal of the American College of Cardiology (1991)
Fatal Asthma After Ingestion of Sulfite-Containing Wine
Authors: Joel Tsevat, Gary N. Gross, Graeme P. Dowling
Journal: Annals of Internal Medicine (1987)

Letters and Corrections1 August 1987Fatal Asthma After Ingestion of Sulfite-Containing WineJOEL TSEVAT, M.D., GARY N. GROSS, M.D., GRAEME P. DOWLING, M.D.JOEL TSEVAT, M.D.Search for more papers by this author, GARY N. GROSS, M.D.Search for more papers by this author, GRAEME P. DOWLING, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-107-2-263_2 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: Allergy to sulfite preservatives is common among asthmatics—as many as 5% to 11% are sulfite-sensitive (1, 2). Fourteen deaths have been precipitated by the ingestion of sulfite-containing foods (1). We report the case of an asthmatic who had a fatal anaphylactic reaction after drinking a glass of wine high in sulfite content. We believe this is the first report of a fatal anaphylactic reaction to wine.A 33-year-old man first developed asthma in 1976 at age 24. He soon required chronic steroid therapy (prednisone, 20 mg/d), theophylline (1200 mg/d), inhaled beta-agonists, and cromolyn sodium. Despite the severity...References1. New sulfite regulations. FDA Drug Bull. 1986;16:17-8. Google Scholar2. YANG W and PURCHASE E. Adverse reactions to sulfites. Can Med Assoc J. 1985;133:865-7,80. Google Scholar3. RIGGS B, HARCHELROD F, and POOLE E. Allergic reaction to sulfiting agents. Ann Emerg Med. 1986;15:77-9. CrossrefMedlineGoogle Scholar4. Labeling of sulfites in alcoholic beverages. Fed Register. 1986;51:34706-10. Google Scholar5. Warning for prescription drugs containing sulfites. FDA Drug Bull. 1987;17:2-3. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: JOEL TSEVAT, M.D.; GARY N. GROSS, M.D.; GRAEME P. DOWLING, M.D. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited bySulfitesReactions to Food and Drug AdditivesAllergic and Immunologic Reactions to Food AdditivesClinical effects of sulphite additivesAssociation Between Quality of Cheap and Unrecorded Alcohol Products and Public Health Consequences in PolandAdverse Reactions to Food and Drug AdditivesAnaphylaxis: can we tell who is at risk of a fatal reaction?Food and beverage preservationAlcoholic drinks and asthmaAsthma and Food AllergyAllergènes potentiels chez les viticulteursChemical additives in seafood productsA diagnostic approach to ‘difficult’ asthmaNew concepts in treatment of chronic persistent asthma 1 August 1987Volume 107, Issue 2Page: 263-263KeywordsAllergy and immunologyAnaphylaxisAsthmaFoodIngestionPreservativesSodiumSteroid therapyWine ePublished: 1 December 2008 Issue Published: 1 August 1987 PDF downloadLoading ...
Autoantibodies and immunoglobulins in collagenous colitis.
Authors: J Bohr, C Tysk, P Yang, D Danielsson, G Jarnerot
Journal: Gut (1996)

BACKGROUND: The aetiology and pathogenesis of collagenous colitis are unknown. Autoimmunity has been suggested, but no serological findings have supported such a theory. AIMS AND METHODS: Serum from 38 collagenous colitis patients and 38 matched healthy controls was analysed for autoantibodies--that is, antinuclear antibodies, antineutrophil cytoplasmic antibodies, smooth muscle and mitochondrial antibodies, rheumatoid factor and antibodies to thyroglobulin and microsomal antigen, together with antibodies to endomysium, gliadin, and cardiolipin. The serum values of IgA, IgG, IgM, and IgG-subclasses, and complement factors C3 and C4 were also determined. RESULTS: In patients with collagenous colitis the mean value of IgM was significantly increased 2.5 g/l (95% CI; 1.9, 3.2) compared with 1.4 g/l (95% CI; 1.2, 1.7) in controls (p = 0.002). Antinuclear antibodies occurred in nine of 38 patients compared with three of 38 controls, this difference was not statistically significant (p = 0.11). The results of all other immunoglobulins, complement factors, and specific antibodies showed no statistical difference between patients and controls. CONCLUSIONS: No firm evidence for an autoimmune genesis in collagenous colitis is found in this study, although the findings of a positive ANA-titre in some patients and an increased IgM level might give some support for this hypothesis.
Vasectomy for contraception
Authors: D. Young
Journal: BMJ (1967)

MEDICATISOHRNAL paramedical, and nursing staff have been observed in the present outbreak, as in the past.Scrupulous attention to hygiene and sterile techniques is necessary to stop the spread of this infection, which can cause painful disability for many weeks with resi- dual corneal opacities.Since fingers seem particularly likely to transfer infection, it would be advisable to use disposable gloves for manipulating eyelids when rushed condi- tions prevent thorough cleansing of hands between patients.-Iam, etc.,
THE COMPARATIVE DANGER OF ETHYL CHLORID AS AN ANESTHETIC
Authors: HORATIO C. WOOD
Journal: JAMA (1910)

Statistics are notoriously unreliable, and yet there are certain problems which can hardly be studied by any other method. A striking illustration of one of the causes which leads to the untrustworthiness of vital statistics is found in the recent paper by Miller<sup>1</sup>on ethyl chlorid anesthesia. In this paper Miller presents the statistics on 43,796 anesthesias with ethyl chlorid, in which there were 5 deaths. In the same paper, however, there are references to some 30 fatalities occurring during ethyl chlorid anesthesia, of which at least 20 are directly attributable to the anesthetic. These cases, however, could not be included in his table, because they were reported as isolated cases without any means of determining the corresponding number of anesthesias which had been produced with safety. Miller from his statistics places the mortality from ethyl chlorid anesthesia at 1 in 8,800 cases. McCardie<sup>2</sup>presents statistics of 9,711
Consultants will fight local pay
Authors: L Beecham
Journal: BMJ (1994)

Britain's senior hospital doctors are determined to continue their fight against the government's proposals to introduce locally negotiated pay for doctors. Speaking at last week's meeting of the BMA's Central Consultants and Specialists Committee, the new chairman, Mr James Johnson, said, “This is a fight that we have got to win for our patients and for the future of British medicine.” In a press statement issued after the meeting he said, “Patients and doctors are united in wanting a national health service with common standards throughout the country and common rates of pay for …
Lipid Encapsulation Enables the Effective Systemic Delivery of Polyplex Plasmid DNA
Authors: James Heyes, Lorne Palmer, Kitty Chan, Cory Giesbrecht, Lloyd Jeffs, Ian MacLachlan
Journal: Molecular Therapy (2007)

Using a new controlled mixing process, highly transfection-competent polyplexes were formed and subsequently encapsulated within a lipid bilayer. The resulting "pre-condensed stable plasmid lipid particles" (pSPLPs) have small size (104+/-3 nm) and low surface charge characteristics. The formulation process equally enabled lipid encapsulation of either poly-L-lysine or poly(ethyleneimine) (PEI) condensed DNA, and the endosomolytic benefits of PEI were demonstrated in in vitro gene expression studies. The clearance properties of pSPLP were compared to similar formulations with an uncondensed payload (SPLP) in A/J mice bearing subcutaneous Neuro-2a tumors. Plasma clearance of pSPLP (t(1/2)=6.6 h) was similar to SPLP (t(1/2)=7.1 h), allowing significant accumulation at distal tumor target sites. Gene expression profiles were evaluated in vivo using the Neuro-2a model, and PEI-pSPLP formulations demonstrated a sixfold increase in reporter gene expression in tumors compared to SPLP. No significant gene expression was observed in the liver, lung, or spleen when mice were treated with either SPLP or pSPLP, and both formulations were equally well tolerated. The results support the lipid encapsulation of polyplex plasmid DNA as a means of changing its pharmacologic properties and enabling systemic delivery. The inclusion of endosomolytic DNA-condensing agents such as PEI greatly improves the potency of SPLP.
Economic Analysis of Influenza Vaccination and Treatment
Authors: Henry Brodkin
Journal: Annals of Internal Medicine (2003)

Letters1 April 2003Economic Analysis of Influenza Vaccination and TreatmentHenry Brodkin, MDHenry Brodkin, MDPermanente Medical Group; Redwood City, CA 94114 (Brodkin)Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-138-7-200304010-00022 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:In their investigation of the economics of influenza treatment, Lee and colleagues (1) neglected to examine several associated costs that, when added, change the conclusions of their article. A policy of using anti-influenza drugs will increase the visits of people with any respiratory infection, who will want to know whether they have a treatable condition. These people would previously have used home treatment for what they had correctly concluded was a cold. Most of these visits will be made during working hours. Some patients will receive incorrect diagnoses, be made ill by the treatment, and again miss ...Reference1. Lee PY, Matchar DB, Clements DA, Huber J, Hamilton JD, Peterson ED. Economic analysis of influenza vaccination and antiviral treatment for healthy working adults. Ann Intern Med. 2002;137:225-31. [PMID: 12186512] LinkGoogle Scholar Author, Article, and Disclosure InformationAuthors: Henry Brodkin, MDAffiliations: Permanente Medical Group; Redwood City, CA 94114 (Brodkin) PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoEconomic Analysis of Influenza Vaccination and Antiviral Treatment for Healthy Working Adults Patrick Y. Lee , David B. Matchar , Dennis A. Clements , Joel Huber , John D. Hamilton , and Eric D. Peterson Economic Analysis of Influenza Vaccination and Treatment Afschin Gandjour Economic Analysis of Influenza Vaccination and Treatment Martin I. Meltzer and Carolyn B. Bridges Economic Analysis of Influenza Vaccination and Treatment Patrick Y. Lee and Eric D. Peterson Economic Analysis of Influenza Vaccination and Treatment Tom Jefferson and Vittorio Demicheli Metrics 1 April 2003Volume 138, Issue 7Page: 607KeywordsDrug policyDrugsUpper respiratory tract infections ePublished: 1 April 2003 Issue Published: 1 April 2003 Copyright & PermissionsCopyright © 2003 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
My brain stem stroke
Authors: G F Grant
Journal: BMJ (1996)

the NHS continues to throw it away..Nationally, we have seen huge sums frittered on useless information systems, and cash is being flooded into general practice fund- holding.Locally, plans in an adjacent district for a new single site hospital on a metropolitan green belt site were turned down by the Department of the Environment.It is sug- gested that the plans, which had little chance of success, cost C6 million.A scanner, bought at a cost of over £400 000 for the Brook Hospital, never worked and has now been
P213Lipoprotein associated phospholipase A2 and high sensitive C-reactive protein levels: a comparison between diabetic and non-diabetic patients with coronary artery disease
Authors: S Das, S K Gupta, G Mp
Journal: Cardiovascular Research (2014)

Background: Lipoprotein-associated phospholipase A2 (Lp-PLA2) enzyme, mainly associated with LDL, hydrolyzes its phospholipids producing proinflammatory compounds like lysophosphatidylcholine and oxidized non-esterified fatty acids. Accumulating evidence suggests Lp-PLA2 to be very good marker of coronary artery disease (CAD). However its role and levels have not been documented clearly in diabetic patients with CAD  in an Indian population. The aim of this study was to explore the association of LpPLA2 levels between diabetic and non-diabetic patients with CAD and compare it with other established markers like hs-CRP.

Methods: Sixty individuals  with  angiographically proven CAD and 30 healthy individuals matched for age & sex were studied. CAD patients were divided into two groups based on presence (n=30) [Group I] and absence (n=30) [group II] of type 2 diabetes mellitus (DM). The serum levels of LpPLA2, hs-CRP were measured by ELISA and routine lipid profile was measured by automated analyzer. Angiographic clinical vessel scoring was also done for all the patients.Data is presented as Mean±S.D. and relationships were determined by Pearson correlations.

Results: Both groups of CAD with and without DM had significantly higher levels of LpPLA2 (Group I-408.48 +/- 38.96 ng/ml, Group II- 272.88 +/- 34.21ng/ml  respectively) and hsCRP (Group I-10.61 +/- 1.34 mg/l, Group II-5.75 +/- 2.59 mg/l respectively) when compared with healthy control subjects (LpPLA2 =200.82 +/- 20.97ng/ml & hsCRP=1.89 +/- 1.34mg/l) [p<0.001]. LpPLA2  levels between the two CAD groups were highly significant(p<0.001), levels  being maximum for CAD with type 2 diabetes (Group I) which could be due an increase in its substrate sLDL and oxidised LDL in DM. Angiographic clinical vessel score of CAD severity was also higher in CAD with DM. LpPLA2 levels correlated strongly (r=0.763,p<0.001) with the angiographic clinical vessel score in diabetes patients with CAD while hsCRP has moderate correlation with the vessel score (r=0.475, p<0.01).

Conclusion: LpPLA2 and hsCRP elevation is  increased in patients of  type 2 diabetes mellitus with CAD as compared to only CAD patients. Measurement of LpPLA2 may be considered as a marker for better prediction of cardiovascular risk in diabetes patients.
Ongoing electronic conference is available for general practitioners
Authors: I. Purves, M. Bainbridge, I. Trimble
Journal: BMJ (1995)

while always maintaining highest medical standards.How best to achieve this will vary depending on local needs, interests, skills, and geography, and the only way forward is by dialogue, col- laboration, and cooperation.Departments that remain blinkered and defensive will not serve the community and are more likely to wither while their populations continue to be at risk.
Ankaferd Blood Stopper as an effective adjunctive hemostatic agent for the management of life-threatening arterial bleeding of the digestive tract
Authors: M. Kurt, S. Kacar, I. Onal, M. Akdogan, I. Haznedaroglu
Journal: Endoscopy (2008)

A 63-year-old man was admitted to our hospital with rectal bleeding. He had a history of Billroth II surgery for bleeding peptic ulcer disease 30 years ago. He had no other medical problems, and was receiving no medications. His hemoglobin level was 5.6 g/dL. Upper gastrointestinal endoscopy revealed fresh blood and clots in the residual stomach and efferent loop. A Dieulafoy lesion with spurting hemorrhage was found near the gastrojejunal anastomosis ([Fig. 1 a]).
Recombinant IL-7/HGFβ efficiently induces transplantable murine hematopoietic stem cells
Authors: Laijun Lai, Mingfeng Zhang, Irving Goldschneider
Journal: Journal of Clinical Investigation (2012)

Difficulty obtaining sufficient hematopoietic stem cells (HSCs) directly from the donor has limited the clinical use of HSC transplantation. Numerous attempts to stimulate the ex vivo growth of purified HSCs with cytokines and growth factors generally have induced only modest increases in HSC numbers while decreasing their in vivo reconstituting ability. We previously developed a recombinant single-chain form of a naturally occurring murine hybrid cytokine of IL-7 and the β chain of hepatocyte growth factor (rIL-7/HGFβ) that stimulates the in vitro proliferation and/or differentiation of common lymphoid progenitors, pre-pro-B cells, and hematopoietic progenitor cells (day 12 spleen colony-forming units) in cultures of mouse BM. Here we used the rIL-7/HGFβ in culture to induce large numbers of HSCs from multiple cell sources, including unseparated BM cells, purified HSCs, CD45- BM cells, and embryonic stem cells. In each instance, most of the HSCs were in the G0 phase of the cell cycle and exhibited reduced oxidative stress, decreased apoptosis, and increased CXCR4 expression. Furthermore, when injected i.v., these HSCs migrated to BM, self-replicated, provided radioprotection, and established long-term hematopoietic reconstitution. These properties were amplified by injection of rIL-7/HGFβ directly into the BM cavity but not by treatment with rIL-7, rHGF, and/or rHGFβ.
Breast feeding reduces risk of breast cancer, says study
Authors: I. Woodman
Journal: BMJ (2002)

Breast feeding can significantly reduce the risk of breast cancer, according to a study by Cancer Research UK. The increase in the disease in developed countries is due to women having fewer children and breast feeding for shorter periods of time, the study says.

The research is a detailed analysis of 47 published studies, with nearly 150 000 participants, from 30 countries.

Breast cancer is the most common cancer in the United Kingdom, with more than 39 000 cases a …
The Radical Abdominal Operation for Carcinoma of the Cervix: Result of One Hundred Cases Based upon Five Years' Freedom from Recurrence
Authors: V. Bonney
Journal: BMJ (1921)

CANCER OF CERVIX.r ErMtDa^man T1103 primary growtlh and secondary mass disappeared, so that, at the end of the twelve months, no growth could be discovered-just a normal sized uterus and cervix, somewhat fixed to the left side of the pelvis with scar tissue; her general health was muchi imuproved, and she was free from pain.Unfortunately, this good result did not last long.Soon the pelvic mass re-formed, and continued to grow in spite of further applications of radium.The bladder and rectum became involved, and the patient died at the end of the second year from mly first seeing her.Tlle net beniefit was probably one year's extra life, and I do not tlhinli the final stage was so distressing as is often the case.Since that time Dr. Burrows has treated a large num-Liber of my cases of carcinoma of the cervix with radium.A large percentage of tllese cases showed a marlied imnproverlent witlh the treatmuent, in many the disease had apparently disappeared when the patient was examined two months after the application, but in only one case of mine hasthe imiiprovement lasted mlorethan one year.This is very disappointing.The initial improvement is, however, so marked that I still hope further experiments with different methods of application m-ay lead to complete cuIre.We must also remiieluber that all these cases were far advanced and iuoperable, probably better results would be obtained-in early cases, but neither Dr. Burrows nor myself yet feel justified in treating early cases with radium alone.The one exception I mentioned above was seen by mne in March, 1918, and then had carcinonma of the cervix which was quite inoperable.Radium was applied in the Christie Hospital in 1918Hospital in , 1919Hospital in , and 1920.She was 47 years of age when first seen, and since the last application has been quiite free from haemnorrhagc.I last saw her in May, 1921, and found the cervix qtuite sm-iooth and with no trace of friability.Wcr teciwi's FHysterectoiny after Radin }}Z.In November, 1916, I was asked to see a patient with Dr. Christie of Longsight.She was 45 years of, age, lhad not passed the menopause, but had had excessive haemor.rhage for six months.We found that she had a large friable carcinoma of the cervix extending on to the vaginal walls.At that time I was advising Wertheim's operation in all cases where operation was possible, but this case was far too advanced for me to attempt opera- tion.Dr. Burrows treated her with radiunm in December, 1916, and in Februarv, 1917, we again examined her.The result was excellent; the cervix had contracted to little above normal size, had lost all its friabilitv, and, so far as we could tell, was not fixed.Apparently the case was now operable, and Dr. Burrows urged me to operate, as