tbuckley/cabot-search huggingface dataset:
TEL/AML1 gene fusion is related to in vitro drug sensitivity for L-asparaginase in childhood acute lymphoblastic leukemia.
Authors: N L Ramakers-van Woerden, R Pieters, A H Loonen, I Hubeek, E van Drunen, H B Beverloo, R M Slater, J Harbott, J Seyfarth, E R van Wering, K Hählen, K Schmiegelow, G E Janka-Schaub, A J Veerman
Journal: Blood (2000)
Dexamethasone induction of hypertension and diabetes is PPAR-α dependent in LDL receptor–null mice
Authors: Carlos Bernal-Mizrachi, Sherry Weng, Chu Feng, Brian N Finck, Russell H Knutsen, Teresa C Leone, Trey Coleman, Robert P Mecham, Daniel P Kelly, Clay F Semenkovich
Journal: Nature Medicine (2003)
Abstract 20661: Vitamin D Deficiency, Tumor Necrosis Factor-Alpha, and Event-Free Survival in Patients With Heart Failure
Authors: Eun Kyeung Song, Debra K Moser, Terry A Lennie
Journal: Circulation (2014)

Background: Vitamin D is related to tumor necrosis factor-alpha (TNF-α), a proinflammatory cytokine that predicts cardiovascular disease. However, whether low vitamin D intake is associated with TNF-α and event-free survival in patients with heart failure (HF) has not been examined. Purpose: To determine whether association of TNF-α with event-free survival differs between patients with vitamin D adequacy and deficiency. Methods: A total of 146 patients with HF (age 63±11 years, 34% female) provided blood to measure serum TNF-α and were divided into 2 groups by median value. Nutrition Analysis program was used to determine intake of vitamin D through a 3-day food diary. Patients with &gt; 80% probability of deficiency were defined as having a diet deficient in vitamin D. Covariate data on age, gender, body mass index, etiology, NYHA class, ejection fraction, comorbidities, and prescribed medications were obtained from review of medical records. Patients were followed for 1 year to determine time to first event of hospitalization or death. Hierarchical logistic and Cox regression was used to address purpose. Results: Eighty-five patients (58%) had vitamin D deficiency. During 1-year, 40 patients (27%) were hospitalized or died. Vitamin D deficiency was associated with higher level of TNF-α (OR=3.10, 95% CI=1.32-7.26). In patients with vitamin D deficiency, higher level of TNF-α (HR=3.08, 95% CI=1.06-8.89) predicted shorter event-free survival after controlling for all covariates, whereas there was no difference in event-free survival between higher and lower level of TNF-α in patients with vitamin D adequacy ( p = .985) . Conclusions: The data suggest that one possible mechanism by which vitamin D deficiency contributed to poor health outcomes is through inflammatory pathways in HF patients. Future study is required to determine whether vitamin D adequacy could play a protective role in the impact of proinflammatory cytokines on event-free survival in HF patients.
Rare localization of low-grade fibromyxoid sarcoma to the nail region
Authors: D. Cabibi, V. Mustacchio, V. Rodolico, E. Barresi, A. Martorana, S. Amato
Journal: British Journal of Dermatology (2005)

Journal Article Rare localization of low‐grade fibromyxoid sarcoma to the nail region Get access D. Cabibi, D. Cabibi Pathology Institute, University School of Medicine, Via del Vespro, 90100 Palermo, Italy *Department of Dermatology, CIVICO Hospital, Via Carmelo Lazzaro, 90100 Palermo, Italy Search for other works by this author on: Oxford Academic Google Scholar V. Mustacchio, V. Mustacchio Pathology Institute, University School of Medicine, Via del Vespro, 90100 Palermo, Italy *Department of Dermatology, CIVICO Hospital, Via Carmelo Lazzaro, 90100 Palermo, Italy V. Mustacchio E‐mail: v.mustacchio@virgilio.it Search for other works by this author on: Oxford Academic Google Scholar V. Rodolico, V. Rodolico Pathology Institute, University School of Medicine, Via del Vespro, 90100 Palermo, Italy *Department of Dermatology, CIVICO Hospital, Via Carmelo Lazzaro, 90100 Palermo, Italy Search for other works by this author on: Oxford Academic Google Scholar E. Barresi, E. Barresi Pathology Institute, University School of Medicine, Via del Vespro, 90100 Palermo, Italy *Department of Dermatology, CIVICO Hospital, Via Carmelo Lazzaro, 90100 Palermo, Italy Search for other works by this author on: Oxford Academic Google Scholar A. Martorana, A. Martorana Pathology Institute, University School of Medicine, Via del Vespro, 90100 Palermo, Italy *Department of Dermatology, CIVICO Hospital, Via Carmelo Lazzaro, 90100 Palermo, Italy Search for other works by this author on: Oxford Academic Google Scholar S. Amato S. Amato Pathology Institute, University School of Medicine, Via del Vespro, 90100 Palermo, Italy *Department of Dermatology, CIVICO Hospital, Via Carmelo Lazzaro, 90100 Palermo, Italy Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 153, Issue 3, 1 September 2005, Pages 686–688, https://doi.org/10.1111/j.1365-2133.2005.06829.x Published: 01 September 2005
Phase I Trial of Selinexor (KPT-330), A First-In-Class Oral Selective Inhibitor Of Nuclear Export (SINE) In Patients (pts) With Advanced Acute Myelogenous Leukemia (AML)
Authors: Ramiro Garzon, Peter de Nully Brown, Karen Yee, Jeffrey E. Lancet, Martin Gutierrez, Nashat Gabrail, Morten Mau-Sorensen, Rachid Baz, John C. Byrd, John Kuruvilla, David S. Siegel, Sharon Shacham, Tami Rashal, Cindy Yf Yau, Ccrp, Dilara McCauley, Jean-Richard Saint-Martin, John McCartney, Yosef Landesman, Boris Klebanov, Greg Pond, Amit M. Oza, Michael Kauffman, Mansoor R Mirza, Richard M. Stone
Journal: Blood (2013)
Free Fetal DNA in Maternal Circulation—Reply
Authors: Ravinder Dhallan, Michael Cronin, Sarah Emche, Philip Bayliss, Marian Damewood
Journal: JAMA (2004)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Abstract 5030: Sex Differences of Carotid Atherosclerotic Plaque: In vivo 3T MRI Study
Authors: Hideki Ota, Mathew J Reeves, David C Zhu, Chun Yuan, J K DeMarco
Journal: Circulation (2009)

Background: Carotid endarterectomy (CEA) to prevent stroke is less beneficial for women compared to men in asymptomatic patients. Sex differences in plaque characteristics may help explain why women receive less benefit from CEA. Numerous plaque features are associated with increased stroke risk such as thin/ruptured fibrous cap, larger lipid-rich/necrotic core (LRNC) and hemorrhage. We tested the hypothesis that within an asymptomatic carotid stenosis population, men have more of these high-risk carotid plaque features than women as detected by in vivo 3T MRI. Methods: One hundred twenty consecutive patients (men, 64, women, 56, age 45– 86) with &gt;=50% asymptomatic carotid stenosis measured by duplex ultrasound were included. Two independent and blinded reviewers interpreted multi-contrast MR images of the more stenotic carotid. Presence of thin/ruptured fibrous cap and plaque components (LRNC, hemorrhage and calcium), and % component volume, if present, were documented. Multivariate logistic and linear regression analyses were used to quantify the association between sex and individual plaque characteristics adjusting for other potential confounders: age, statin use, smoking, history of hyperlipidemia, hypertension, coronary artery disease and diabetes. Results: The prevalence of plaque features and % volume components in men versus women were, respectively: thin/ruptured fibrous cap (47% vs 20%, p&lt;0.01), LRNC (72% vs 48%, p=0.01), hemorrhage (31% vs 17%, p=0.11) and calcium (84% vs 89%, p=0.45); mean % volume of LRNC (5.7% vs 2.4%, p&lt;0.01), hemorrhage (2.2% vs 0.3%, p=0.03) and calcium (4.6% vs 4.1%, p=0.58). Only statin use was found to be a significant confounder and included in the multivariate models. The adjusted odds ratio (aOR) were significantly greater for men (vs women) for presence of thin/ruptured fibrous cap (aOR, 3.5, 95%CI= 1.5, 8.0), and LRNC (aOR 3.6, 95%CI= 1.6, 8.1). Plaque volumes were also significantly larger in men for % LRNC (3.7%, 95%CI= 1.6, 5.7%), and % hemorrhage volume (1.9%, 95% CI=0.5, 3.2%). Conclusion: In patients with asymptomatic &gt;=50% carotid stenosis, men tended to have higher-risk plaque features than women. These findings indicate a possible reason for why CEA is less effective in asymptomatic women. This research has received full or partial funding support from the American Heart Association, Midwest Affiliate (Illinois, Indiana, Iowa, Kansas, Michigan, Minnesota, Missouri, Nebraska, North Dakota, South Dakota &amp; Wisconsin).
A new horizon for liver support in acute liver failure
Authors: Nathan A Davies, Rafael Bañares
Journal: Journal of Hepatology (2015)

Acute liver failure (ALF) is a relatively uncommon disease usually affecting young people without preexisting liver disease. Its clinical spectrum includes not only severe derangement of liver function, but also multi-organ failure and a high risk of sepsis, explaining the strong association between ALF and mortality that exceeds 50% [1]. Liver transplantation is the only therapeutic approach that has shown a survival benefit in patients with severe ALF. However, the shortage of organs for transplantation or the existence of contraindications limits the applicability of the procedure. In addition, the need of long-life immunosuppressive therapy in these young patients associates a relevant long-term morbidity and mortality. On the other hand, when spontaneous resolution occurs, the liver usually recovers completely. Therefore it is not surprising that during the last decades, several attempts of providing temporary support of ALF patients have been described. In this context, the development of extracorporeal liver support devices would be important for maintaining the patient’s condition until the spontaneous recovery of liver function occurs or until an organ becomes available. From a theoretical perspective, an effective extracorporeal liver support system should replace three major functions of the liver: detoxification, biosynthesis and regulation. In the setting of ALF, the main goals would be to remove putative toxins preventing further aggravation of liver failure, to stimulate liver regeneration and to improve the pathophysiological features of ALF [2]. Toxin removal by high volume plasmapheresis has been tested with some evidence of success, however it is difficult to draw conclusions on this approach as the single study performed in ALF has so far only been presented in abstract form [3]. Clinically, the goal should be to provide liver and support for other organs with the aim of avoiding transplantation or bridging the patient to the procedure in the best possible condition. Extracorporeal liver support systems clinically tested fall into two main categories: (i) the purely artificial systems that are based on the principles of adsorption and filtration and are aimed to remove circulating toxins by using a variety of membranes and adsorbents; and (ii) the bioartificial systems that are hybrid devices that incorporate liver cells/hepatocytes in order to
Effects of age, sex, and body habitus on QRS and ST-T potential maps of 1100 normal subjects.
Authors: L S Green, R L Lux, C W Haws, R R Williams, S C Hunt, M J Burgess
Journal: Circulation (1985)

Body surface potential maps provide more detailed regional cardiac electrophysiologic information than the standard electrocardiogram. We performed a large-scale study of a normal population to form a comparison base for evaluation of the clinical utility of this technique. We analyzed body surface maps from 1113 normal subjects from 10 to 80 years old to detail map features as a function of age, sex, and body habitus. Maps were analyzed by visual inspection and by a spatial and temporal data reduction technique that allows statistical comparison of map features. On average, both QRS and ST-T potentials decreased with increasing age. Potential pattern distributions remained constant from 10 to 40 years. Beyond age 40, larger numbers of maps from normal subjects showed depolarization patterns consistent with delayed activation of the left anterior fasicle, despite normal 12-lead electrocardiograms. Only minor QRS potential amplitude and distribution differences were noted when male and female subjects were compared within groups of similar age and body habitus. Male subjects consistently showed greater average T potential amplitudes. Slender body habitus was associated with a more horizontal "zero" potential line. In female subjects over age 40 there were more extensive low-level negative potentials recorded over the precordium during the ST segment than in men. This study defines the range of normal body surface potential maps in a large clinically normal population and provides a basis for qualitative and statistical comparison with map features of patients with disease.
Abstract 15308: SPARC Deletion Suppresses Age-related Cardiac Inflammation
Authors: Hiroe Toba, Lisandra E de Castro Brás, Catalin F Baicu, Michael R Zile, Merry L Lindsey, Amy D Bradshaw
Journal: Circulation (2014)

Secreted protein acidic and rich in cysteine (SPARC) is a collagen-binding matricellular protein that facilitates the formation and assembly of mature cross-linked collagen fibrils. We previously reported that aged mice exhibit increased SPARC levels in the heart, and SPARC deletion inhibits age-related collagen deposition. The present study investigated whether SPARC deletion could suppress age-related cardiac inflammation. Six groups of mice were studied: young (3-5 month old), middle-aged (10-12 m.o.) and old (18-29 m.o.) C57BL/6J wild type (WT) and SPARC-null (Null) mice (n=5-10 per group). Echocardiography and histology revealed that LV wall thickness and myocyte size were 15% and 43% increased with age in WT, respectively (both p&lt;0.05 old versus young). These age-dependent structural changes were blunted in the Null. The pro-inflammatory chemokines Ccl5 and Ccr2 were increased in middle-aged and old WT, and Cxcl1 was increased in old WT, compared to young WT (all p&lt;0.05). Interestingly, the age-dependent increases in Ccl5, Ccr2, and Cxcl1 were delayed in Null. Migration inhibitory factor (Mif) and Cx3cl1 showed an age-dependent increase in both WT and Null. Cxcl5 expression levels increased age-dependently only in Null, suggesting a compensatory increase for the decline of other chemokines. In summary, these results suggest that SPARC deletion slowed age-related cardiac inflammation.
Detoxification and Treating Opioid Dependence
Authors: Catherine J de Jong
Journal: JAMA (2006)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Abstract P6-09-09: Body mass index and prognosis after breast cancer diagnosis in Japanese women
Authors: Toshinari Yamashita, Tomoyuki Aruga, Hiromi Miyamoto, Kazumi Horiguchi, Yayoi Honda, Nami Idera, Risa Goto, Katsumasa Kuroi
Journal: Cancer Research (2015)

Abstract Background: Studies conducted mainly in Western countries have reported a relationship between body mass index (BMI) and prognosis among women with breast cancer. Only a few studies have been conducted in Japan so far because the percentage of high BMI is low. In the present retrospective study, we investigated the associations between BMI and the clinical characteristics and prognosis among breast cancer patients. Methods: We analyzed 1,744 breast cancer patients who started treatment between 2004 and 2012 at a single hospital in Japan. All patients with ductal carcinoma in situ, male breast cancer as well as metachronous and synchronous bilateral breast cancer were excluded. Median age was 57 years (range 23–91). The number of patients less than 50 years old was 496. World Health Organization BMI classifications were used: Underweight, less than18.5 kg/m2, n=157; Normal, 18.5–24.9 kg/m2, n=1181; Overweight, 25–29.9 kg/m2, n=316; and Obese, more than or equal to 30kg/m2, n=90. The Cox proportional hazards model was used to estimate hazard ratios for recurrence free survival (RFS) in relation to BMI classifications. Results: Median follow up interval was 4.2 years. During the follow-up period, 126 breast cancer recurrences were observed. BMI classification correlated with clinical tumor size (cT) significantly and BMI classification tended to correlate with lymph node metastases and estrogen receptor (ER) status. Among patients less than 50 years old, the RFS of those with BMI ≥25.0 kg/m2 was compared to that of patients with BMI &amp;lt;25.0 kg/m2. In multivariate analyses, BMI classification was one of the significant factors (p=0.02) along with lymph node metastases (p=0.0001) and ER status (p=0.04). However in patients aged 50 years or over BMI category was not a significant factor (p=0.12). Conclusions: It has been reported that higher BMI is a risk factor for breast cancer recurrence among postmenopausal patients. Our results suggest that higher BMI is also associated with an increased risk of breast cancer recurrence among premenopausal patients. It raises the possibility that maintaining an appropriate body weight improves the prognosis in premenopausal patients after they have been diagnosed. Citation Format: Toshinari Yamashita, Tomoyuki Aruga, Hiromi Miyamoto, Kazumi Horiguchi, Yayoi Honda, Nami Idera, Risa Goto, Katsumasa Kuroi. Body mass index and prognosis after breast cancer diagnosis in Japanese women [abstract]. In: Proceedings of the Thirty-Seventh Annual CTRC-AACR San Antonio Breast Cancer Symposium: 2014 Dec 9-13; San Antonio, TX. Philadelphia (PA): AACR; Cancer Res 2015;75(9 Suppl):Abstract nr P6-09-09.
Oral health care systems in developing and developed countries
Authors: Daniel Kandelman, Sophie Arpin, Ramon J. Baez, Pierre C. Baehni, Poul E. Petersen
Journal: Periodontology 2000 (2012)

Abstract Health care systems are essential for promoting, improving and maintaining health of the population. Through an efficient health service, patients can be advised of disease that may be present and so facilitate treatment; risks factors whose modification could reduce the incidence of disease and illness in the future can be identified, and further, how controlling such factors can contribute to maintain a good quality of life. In developed countries, clinics or hospitals may be supported by health professionals from various specialties that allow their cooperation to benefit the patient; these institutions or clinics may be equipped with the latest technical facilities. In developing countries, health services are mostly directed to provide emergency care only or interventions towards certain age group population. The most common diseases are dental caries and periodontal disease and frequently intervention procedures aim, at treating existing problems and restore teeth and related structure to normal function. It is unfortunate that the low priority given to oral health hinders acquisition of data and establishment of effective periodontal care programmes in developing countries but also in some developed countries where the periodontal profile is also less than satisfactory. Despite the fact that in several developed countries there are advanced programmes oriented to periodontal disease treatments, the concern is related to the lack of preventive oriented treatments. According to data available on periodontal status of populations from developed countries, despite the number of dentists and trained specialists, dental health professionals do not presently meet adequately the need for prevention, focusing mainly on curative care. The need for strengthening disease prevention and health promotion programmes in order to improve oral health conditions and particularly periodontal status in the majority of countries around the world is evident. Unfortunately, in many countries, the human, financial and material resources are still insufficient to meet the need for oral health care services and to provide universal access, especially in disadvantaged communities, in both developing and developed countries. Moreover, even though the most widespread illnesses are avoidable, not all population groups are well informed about or able to take advantage of the proper measures for oral health promotion. In addition, in many countries, oral health care needs to be fully integrated into national or community health programmes. Improving oral health is a very challenging objective in developing countries, but also in developed countries, especially with the accelerated aging of the population now underway and intensifying over the coming years.