tbuckley/cabot-search huggingface dataset:
ANTI-CANDIDAL AGGLUTINATING ANTIBODY
Authors: LEWIS SLATER
Journal: Annals of Internal Medicine (1969)

Letters and Comments1 May 1969ANTI-CANDIDAL AGGLUTINATING ANTIBODYLEWIS SLATER, M.D.LEWIS SLATER, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-70-5-1047_2 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the Editor: Drs. Preisler, Hasenclever, Levitan, and Henderson (Ann. Intern. Med. 70: 19, 1969) report a significant rise in agglutinating antibody titer in 14 of 23 patients with acute leukemia who had visceral candidiasis at autopsy. They felt that there was no statistically significant difference in their patients with regard to age, sex, variety, or duration of leukemia, year of diagnosis, or length of time on study. They also felt that the incidence of leukopenia, granulocytopenia, and lymphopenia was similar.Since this is a population of patients who require frequent transfusions of blood or blood products, the possible role... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: LEWIS SLATER, M.D. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 May 1969Volume 70, Issue 5Page: 1047-1048KeywordsAutopsyBlood transfusionCandidiasisLymphopenia ePublished: 1 December 2008 Issue Published: 1 May 1969 PDF downloadLoading ...
Accidents and antidepressants
Authors: K McKenzie
Journal: BMJ (1994)

When drug company representatives come to tell me of another good reason for prescribing selective serotonin reuptake inhibitors (SSRIs) I feel like screaming. The unprecedented campaign to unseat tricyclic antidepressants from their lucrative throne has, at times, made me feel like I am being brainwashed. So when I saw “Death by Prescription” in the comfort of my own home, and with no need for a professional veneer, my screech was so loud it nearly woke up my children.

The World in Action team's story was built on the facts that prescribed drugs which work on the central nervous system can impair your performance and that as many as 16% …
NHS faces critical shortfall in number of consultant surgeons
Authors: C. White
Journal: BMJ (2001)

AKI is a syndrome, not a disease. It results from many different primary and/or secondary etiologies and is often multifactorial, especially in the hospitalized patient. This review discusses the pathophysiology of three etiologies that cause AKI, those being kidney hypoperfusion, abdominal compartment syndrome, and urinary tract obstruction. The pathophysiology of these three causes of AKI differs but is overlapping. They all lead to a low urine flow rate and low urine sodium initially. In all three cases, with early recognition and correction of the underlying process, the resulting functional AKI can be rapidly reversed. However, with continued duration and/or increased severity, cell injury occurs within the kidney, resulting in structural AKI and a longer and more severe disease state with increased morbidity and mortality. This is why early recognition and reversal are critical.
Myelokathexis — A New Form of Chronic Granulocytopenia
Authors: Wolf W. Zuelzer, Ruth K. Evans, Jody Goodman
Journal: New England Journal of Medicine (1964)

THE quantitative analysis of granulopoiesis requires knowledge not only of the complex relations between cytologic compartments within the bone marrow but also of the distribution and fate of cells capable of leaving the vascular bed after only a brief sojourn in the bloodstream and under conditions not readily accessible to observation. The genesis of many of the granulocytopenic states has thus remained obscure. In certain types increased peripheral destruction by a variety of mechanisms has been invoked. In others it is possible to relate the lack of granulocytes in the blood to a primary disturbance in bone-marrow function leading to . . .
Contact Dermatitis To Atropine
Authors: C.A. Villanueva Alvarez-Santullano, V. Tovar Flores, P. Tornero Molina, M. De Barrio Fernandez, M. Baeza Ocho de Ocariz, S. Perez Bustamante, A. Prieto Garcia
Journal: Journal of Allergy and Clinical Immunology (2007)
Laboratory devised prostaglandin derivatives offer antiulcer promise
Authors: John Henahan
Journal: JAMA (1985)

A new class of antiulcer drugs—it is hoped—may be as effective as the histamine receptor antagonists (H<sub>2</sub>blockers) in inhibiting gastric acid secretion. However, the activity of this new class may go beyond that, according to a series of clinical trials presented at two medical conferences in Portugal— the XII International Congress of Gastroenterology in Lisbon, and a symposium on prostaglandins in the Algarve. The new drugs are laboratory devised derivatives of naturally occurring prostaglandins. Preliminary indications are that, in addition to inhibiting gastric acid secretions and helping to heal ulcers, they may protect the gastroduodenal mucosa against potential damage from aspirin, alcohol, and other agents. As such, they might be particularly useful in patients with rheumatoid arthritis and for other persons who routinely ingest large amounts of nonsteroidal anti-inflammatory agents, some of the conference reports suggest. However, larger clinical trials remain to be done, and questions about factors
4-Hydroxynonenal as a selective pro-fibrogenic stimulus for activated human hepatic stellate cells
Authors: Elena Zamara, Erica Novo, Fabio Marra, Alessandra Gentilini, Roberto Giulio Romanelli, Alessandra Caligiuri, Gaia Robino, Elena Tamagno, Manuela Aragno, Oliviero Danni, Riccardo Autelli, Sebastiano Colombatto, Mario Umberto Dianzani, Massimo Pinzani, Maurizio Parola
Journal: Journal of Hepatology (2003)
Benzene-induced myelotoxicity: application of flow cytofluorometry for the evaluation of early proliferative change in bone marrow.
Authors: R D Irons
Journal: Environmental Health Perspectives (1981)

A detailed description of flow cytofluorometric DNA cell cycle analysis is presented. A number of studies by the author and other investigators are reviewed in which a method is developed for the analysis of cell cycle phase in bone marrow of experimental animals. Bone marrow cell cycle analysis is a sensitive indicator of changes in bone marrow proliferative activity occurring early in chemically-induced myelotoxicity. Cell cycle analysis, used together with other hematologic methods, has revealed benzene-induced toxicity in proliferating bone marrow cells to be cycle specific, appearing to affect a population in late S phase which then accumulate in G2/M.
The Presence of Mutations in Epidermal Growth Factor Receptor Gene Is Not a Prognostic Factor for Long-Term Outcome after Surgical Resection of Non–Small-Cell Lung Cancer
Authors: Young Tae Kim, Yong Won Seong, Yoo Jin Jung, Yoon Kyung Jeon, In Kyu Park, Chang Hyun Kang, Joo Hyun Kim
Journal: Journal of Thoracic Oncology (2013)
1376 THE ASPIRE TRIAL: TMC435 IN TREATMENT-EXPERIENCED PATIENTS WITH GENOTYPE-1 HCV INFECTION WHO HAVE FAILED PREVIOUS PEGIFN/RBV TREATMENT
Authors: S. Zeuzem, G.R. Foster, M.W. Fried, C. Hezode, G.M. Hirschfleld, I. Nikitin, F. Poordad, O. Lenz, M. Peeters, V. Sekar, G. De Smedt
Journal: Journal of Hepatology (2011)
Recurrent BRCA2 6174delT mutations in Ashkenazi Jewish women affected by breast cancer
Authors: Susan Neuhausen, Teresa Gilewski, Larry Norton, Thao Tran, Peter McGuire, Jeff Swensen, Heather Hampel, Patrick Borgen, Karen Brown, Mark Skolnick, Donna Shattuck-Eidens, Suresh Jhanwar, David Goldgar, Kenneth Offit
Journal: Nature Genetics (1996)
Ian William Payne
Authors: S. Pearkes
Journal: BMJ (2014)

After qualifying in 1946 Ian William Payne became a house surgeon at Manchester Royal Eye Hospital. From 1947 (the year of his marriage) to 1949, he served as a captain in the Royal Army Medical Corps (national service), and in 1949 he was appointed as demonstrator of anatomy at Manchester University. In 1949 he obtained his Diploma in Ophthalmic Medicine and Surgery, followed by the FRCS in 1953. In 1950 he moved to London and became house surgeon and then senior registrar at the Royal Eye Hospital in St George’s Circus, where he remained until 1955, when he moved with his family to the edge of Dartmoor in Devon and took up his post as consultant ophthalmologist at Plymouth Royal Eye Infirmary. He remained there until he retired in 1987.

During his early years in Plymouth, there were no junior medical staff, and he was on call one week in three, necessitating many night calls and visits to the hospital. With the appointment of a fourth consultant and then two or three house surgeons, the workload became easier, which was also helped by the cessation of the regular Saturday morning outpatient clinic. During those early years, he had little time to spend with his family and would often suffer from the “weekend migraine syndrome,” forcing him to bed and reducing his family time still further.

He took a great interest in the further education of his junior medical staff and would hold regular classes in optics after hours, a subject he felt was much neglected, but vitally important. He believed that a working knowledge of optics was essential for every ophthalmologist. He made models from Perspex and thread to demonstrate the refraction of light through lenses, and would spend many hours preparing teaching materials for these sessions.

In addition, he …
Warning from British Columbia
Authors: D L Sweeney
Journal: BMJ (1975)

NHS family planning services SIR,-In the BM7 (19 July, p 185) it is re- ported that "the profession's negotiators [our italics] and the DHSS have agreed a scheme for the provision of family planning services through the hospital service, for all FP work, whether of medical or social origin."We are astonished that there has been, as yet, minimal medical or public reaction to this retrograde proposal.It is the feeling of the undersigned staff of the obstetrical and gynaecological department in Aberdeen that this scheme is indisputably bad.The reasons for its introduction are far from obvious and the advantages in terms of patient care are difficult to define.Furthermore, it may turm out to have a dangerously disruptive effect among different grades of staff in many gynaecological and anaesthetic departments, including theatre staff and porters.It seems ludicrous for a health service short of money in a time of rapid inflation to put out extra money to its highest paid workers.This is all apart from the questionable morality of the scheme and the inevitable difficulties it will present in the counselling of patients who seek unbiased family planning advice.
EFFECT OF KETONE BODIES AND OTHER METABOLITES ON THE SURVIVAL AND MULTIPLICATION OF STAPHYLOCOCCI AND TUBERCLE BACILLI
Authors: René J. Dubos
Journal: The Journal of Experimental Medicine (1953)

A study has been made of the fate of staphylococci and tubercle bacilli resuspended in aqueous media at slightly acid reactions. The tests were carried out at several acid reactions in balanced ionic media containing 0.5 per cent serum albumin. These experimental conditions were selected in order to approximate those which are probably encountered by pathogenic agents in inflammatory areas and in the intracellular environment of the leucocytes after phagocytosis. The viability of the microorganisms at a given pH was markedly influenced by the composition of the medium, being decreased by addition to the latter of lactic, acetic, propionic, and butyric acids, and increased by the addition of certain ketone bodies such as dihydroxyacetone and pyruvic, beta-hydroxybutyric, alpha-ketoglutaric, and oxalacetic acids. The presence of ketone bodies in the medium afforded to the microorganisms some protection against the bactericidal effect of lactic and acetic acids at acid reactions. The minimum and the optimum pH for growth were found to be dependent on the composition of the medium. Both were higher in the presence of lactic, acetic, propionic, and butyric acids than in the media without organic acids added. In contrast, the addition of ketone bodies to the medium allowed microbial multiplication even in acid media (approximately at pH 5.3 or even lower). The fact that lactic acid antagonizes, whereas ketone bodies favor, the survival and multiplication of staphylococci and tubercle bacilli at acid reactions, is discussed in relation to the high susceptibility to infection which is often associated with ketosis of various etiology.
Indium-111 Capromab Pendetide (ProstaScint) Imaging to Detect Recurrent and Metastatic Prostate Cancer
Authors: JOHN D. PETRONIS, FINTAN REGAN, KE LIN
Journal: Clinical Nuclear Medicine (1998)

This study evaluated the utility of In-111 capromab pendetide imaging to detect prostate cancer metastases or local recurrence. The specific goal was to identify clinical factors such as prostate-specific antigen, pathologic stage, and Gleason score that were most predictive of a positive scan outcome. In addition, a new concept of a weighted Gleason score was defined and correlated with the scan outcome. Fifty-one patients with an elevated prostate-specific antigen level and otherwise negative workup were studied. Forty-eight patients had been treated by radical prostatectomy, two by radiation therapy, and one patient was studied before prostatectomy. Each patient received an intravenous injection of approximately 5 mCi of In-111 containing 0.5 mg of CYT 356, a conjugated site-specific monoclonal antibody against prostate specific membrane antigen. Tomographic blood pool images were obtained the day of injection. Four days later planar images and tomographic images of the abdomen and pelvis were obtained. Scans were interpreted by two experienced nuclear medicine physicians. Differences in the scan interpretation were settled by consensus. Scan outcomes were correlated with prostate-specific antigen levels, pathologic stage, Gleason score, weighted Gleason score, and clinical data. Of 51 scans, 70.6% (36 of 51) were positive. Eight patients had abnormal activity in the prostatic fossa, 12 patients had abnormal activity in the abdominal or pelvic lymph nodes, and 16 patients demonstrated abnormal activity in both areas. One patient with a positive scan underwent lymphadenectomy and was confirmed to be a true positive. Patients with a prostate-specific antigen level greater than 10 ng/ml, a weighted Gleason score higher than 4.5, or prostate-specific antigen levels greater than 2 ng/ml plus a weighted score higher than 4.5 showed positive rates of 100% (6 of 6), 88.2% (14 of 16), and 100% (6 of 6), respectively. In-111 capromab pendetide imaging was useful to detect metastases or local recurrence. Serum prostate-specific antigen levels and weighted Gleason scores are good predictive factors of the likelihood of a positive scan outcome.
Differences in the pattern of hippocampal neuronal loss in normal ageing and Alzheimer's disease
Authors: M.J West, P.D Coleman, D.G Flood, J.C Troncoso
Journal: The Lancet (1994)

SummaryThe distinction between the neurodegenerative changes that accompany normal ageing and those that characterise Alzheimer's disease is not clear. The resolution of this issue has important implications for the design of therapeutic and investigative strategies. To this end we have used modern stereological techniques to compare the regional pattern of neuronal cell loss in the hippocampus related to normal ageing to that associated with Alzheimer's disease.The loss related to normal ageing was evaluated from estimates of the total number of neurons in each of the major hippocampal subdivisions of 45 normal ageing subjects who ranged in age from 13 to 101 years. The Alzheimer's disease related losses were evaluated from similar data obtained from 7 cases of Alzheimer's disease and 14 age matched controls. Qualitative differences were observed in the regional patterns of neuronal loss related to normal ageing and Alzheimer's disease. The most distinctive Alzheimer's disease related neuron loss was seen in the CA1 region of the hippocampus. In the normal ageing group there was almost no neuron loss in this region (final neuron count in the CA1 region: 4·40 X 106 neurons for the Alzheimer's disease group vs 14·08 × 106 neurons in the normal ageing group).It is concluded that the neurodegenerative processes associated with normal ageing and with Alzheimer's disease are qualitatively different and that Alzheimer's disease is not accelerated by ageing but is a distinct pathological process.
Linkage between the frequency of muscular weakness and loci that regulate immune responsiveness in murine experimental myasthenia gravis.
Authors: P W Berman, J Patrick
Journal: The Journal of Experimental Medicine (1980)

Mice immunized with acetylcholine receptor (AChR) purified from Torpedo californica form anti-AChR antibodies and often develop muscular weakness and flaccid paralysis closely resembling the human disease myasthenia gravis. This condition, termed experimental myasthenia gravis (EMG), is strain dependent in that the frequency of paralysis is much greater in some strains than in others. Differences in the frequency of EMG might result from differences in the immune system or the neuromuscular junction. In these studies, we have identified two loci, the major histocompatibility complex (H-2) region on chromosome 17 and the region that contains the structural genes for the constant region of immunoglobulin heavy chains (IgCH region) on chromosome 12, which significantly effect the probability with which a mouse immunized with T. californica AChR can be expected to become paralyzed. One genotype (H-2b, Ig-1b) correlated with high susceptibility to EMG in four strains with three dissimilar backgrounds. These studies demonstrate that susceptibility to EMG is a heritable trait determined by at least two distinct loci that are linked to regions of the mouse genome that regulate immune responsiveness.
Contemporary practice of coronary revascularization in U.S. hospitals and hospitals participating in the bypass angioplasty revascularization investigation (BARI)
Authors: Katherine M. Detre, Allan D. Rosen, James E. Bost, Margaret E. Cooper, Kim Sutton-Tyrrell, Richard Holubkov, Richard J. Shemin, Robert L. Frye
Journal: Journal of the American College of Cardiology (1996)
Diurnal Blood Pressure Pattern in Patients with Ischemic and Dilated Cardiomyopathy
Authors: Ercan Taştan, Hasan Murat Uğurlu, Mehmet Han Mercen, İlyas Kaya, Mehmet Zihni Bilik, Mehmet Serdar Soydinç
Journal: Journal of the American College of Cardiology (2013)
Effect of a High-Protein, High–Monounsaturated Fat Weight Loss Diet on Glycemic Control and Lipid Levels in Type 2 Diabetes
Authors: Barbara Parker, Manny Noakes, Natalie Luscombe, Peter Clifton
Journal: Diabetes Care (2002)

OBJECTIVE—To determine the effect of a high-protein (HP) weight loss diet compared with a lower-protein (LP) diet on fat and lean tissue and fasting and postprandial glucose and insulin concentrations. RESEARCH DESIGN AND METHODS—Replacing dietary protein for carbohydrate (CHO) during energy restriction and weight loss has been effective in sparing lean mass and improving insulin sensitivity in obese subjects but has not been tested in subjects with type 2 diabetes. We compared an HP diet (28% protein, 42% CHO, 28% fat [8% saturated fatty acids, 12% monounsaturated fatty acids, 5% polyunsaturated fatty acids]) with an LP diet (16% protein, 55% CHO, 26% fat [8% saturated fatty acids, 11% monounsaturated fatty acids, 5% polyunsaturated fatty acids]) in 54 obese men and women with type 2 diabetes during 8 weeks of energy restriction (1,600 kcal) and 4 weeks of energy balance. Body composition was determined by dual-energy X-ray absorptiometry at weeks 0 and 12. RESULTS—Overall, weight loss of 5.2 ±1.8 kg was achieved independently of diet composition. However, women on the HP diet lost significantly more total (5.3 vs. 2.8 kg, P=0.009) and abdominal (1.3 vs. 0.7 kg, P=0.006) fat compared with the women on the LP diet, whereas, in men, there was no difference in fat loss between diets (3.9 vs. 5.1 kg). Total lean mass decreased in all subjects independently of diet composition. LDL cholesterol reduction was significantly greater on the HP diet (5.7%) than on the LP diet (2.7%) (P &amp;lt; 0.01). CONCLUSIONS—Both dietary patterns resulted in improvements in the cardiovascular disease (CVD) risk profile as a consequence of weight loss. However, the greater reductions in total and abdominal fat mass in women and greater LDL cholesterol reduction observed in both sexes on the HP diet suggest that it is a valid diet choice for reducing CVD risk in type 2 diabetes.
Development of Functional Poly(amido amine) CXCR4 Antagonists with the Ability to Mobilize Leukocytes and Deliver Nucleic Acids
Authors: Yan Wang, Stuart T. Hazeldine, Jing Li, David Oupický
Journal: Advanced Healthcare Materials (2014)

CXCR4 chemokine receptor plays a crucial role in metastatic spread of multiple types of cancer. The present study reports on synthesis of functional polymers based on newly synthesized CXCR4-inhibiting monomers. The resultant linear polymeric CXCR4 antagonists (PCX) show improved ability to inhibit CXCR4 when compared with the monomers. The CXCR4 antagonism provides PCX with the ability to mobilize leukocytes from bone marrow to peripheral blood and to inhibit cancer cell invasion. Due to their cationic nature, PCX can form polyplexes with DNA and mediate efficient transfection. The reported findings validate PCX as promising dual-function polymeric drugs that can deliver therapeutic nucleic acids and improve cancer therapy by simultaneously inhibiting CXCR4 chemokine receptor.
The effects of increasing effective airway diameter on weaning from mechanical ventilation in tracheostomized patients: a randomized controlled trial
Authors: Gonzalo Hernandez, Ana Pedrosa, Ramon Ortiz, Maria del Mar Cruz Accuaroni, Rafael Cuena, Concepción Vaquero Collado, Susana García Plaza, Paloma González Arenas, Rafael Fernandez
Journal: Intensive Care Medicine (2013)
DIAGNOSTIC PERFORMANCES OF CORONARY COMPUTED TOMOGRAPHIC ANGIOGRAPHY AND INTRAVASCULAR ULTRASOUND IN THE EVALUATION OF ISCHEMIA CAUSING CORONARY STENOSIS BY FRACTIONAL FLOW RESERVE: DIRECT COMPARISON AMONG IMAGING VERSUS PHYSIOLOGY
Authors: Joon Hyung Doh, Bon-Kwon Koo, Chang-Wook Nam, Ji-Hyun Kim, Hyo-Soo Kim, Sung Yun Lee, Hyunmin Choe, June Namgung, Se Mi Oh, James Min
Journal: Journal of the American College of Cardiology (2012)
Routine telephone review of asthma: Authors' reply
Authors: H. Pinnock
Journal: BMJ (2003)

EDITOR—We acknowledged in our discussion that only a third of eligible patients participated in our trial raising concerns about generalisability. Having identified a group reluctant to attend asthma clinics, achieving a high response rate to a postal invitation was always going to be difficult. As detailed in our paper, of the 307 excluded for other reasons, 50% had chronic obstructive pulmonary …