THROMBOCYTOPENIC PURPURA FOLLOWING QUINIDINE THERAPY
Authors: H E NUSSBAUM, M W SHULMAN
Journal: Annals of Internal Medicine (1952)

Case Reports1 July 1952THROMBOCYTOPENIC PURPURA FOLLOWING QUINIDINE THERAPYHARVEY E. NUSSBAUM, M.D., F.A.C.P., MURRAY W. SHULMAN, M.D.HARVEY E. NUSSBAUM, M.D., F.A.C.P.Search for more papers by this author, MURRAY W. SHULMAN, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-37-1-190 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptUntil most recently, thrombocytopenic purpura occurring during the administration of quinidine was unknown. The fact is well established that its levorotatory isomer, quinine, and related levorotatory compounds, ethylhydrocupreine and cinchonidine, can produce idiosyncrasy,1 and especially that quinine can be the cause of suppression of blood platelets with consequent hemorrhagic manifestations.2, 3 It had been generally assumed that their dextrorotatory counterpart was singularly incapable of producing toxic manifestations.Subsequent to Broch's report in 1941 of a case of thrombocytopenic purpura during quinidine therapy,4the world literature is completely free of reports until a report in 1947 by Soisalo of a similar...Bibliography1. DawsonGarbade WTFA: Idiosyncrasy to quinine, cinchonidine and ethyl hydro-cupreine and other laevo-rotatory alkaloids of the cinchona series: preliminary report, J. A. M. A. 94: 704 (March) 1930. CrossrefGoogle Scholar2. PeshkinMiller MJA: Quinine and ergot allergy and thrombocytopenic purpura: report of a case, J. A. M. A. 102: 1737-1740 (May 26) 1934. CrossrefGoogle Scholar3. Grandjean LC: Case after administration of quinine with specific thrombocytolysis demonstrated in vitro, Acta med. Scandinav. (supp. 213) 131: 165-170, 1948. Google Scholar4. Broch OJ: Thrombocytopenic purpura after administration of quinidine, Nord. med. 10: 1542-1544 (May 17) 1941. Google Scholar5. Soisalo P: Thrombocytopenic purpura produced by quinidine, Ann. med. int. Fenniae 36: 181-184, 1947. MedlineGoogle Scholar6. NudelmanLeffHowe PJILCD: Thrombopenic purpura following quinidine, J. A. M. A. 137: 1219-1220 (July 31) 1948. CrossrefMedlineGoogle Scholar7. Larimer RC: Thrombocytopenic purpura following quinidine therapy, Canad. M. A. J. 60: 508, 1949. MedlineGoogle Scholar8. Norcross JW: Quinidine as a cause of thrombocytopenic purpura, New England J. Med. 242: 53 (Jan. 12) 1950. CrossrefMedlineGoogle Scholar9. Collins DC: Atypical secondary or symptomatic thrombocytopenic purpura developing with the use of quinidine sulfate, Circulation 2: 438, 1950. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Newark, New Jersey*Received for publication December 6, 1950. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byBIBLIOGRAPHYQUINIDINE PURPURA: REPORT OF SIX CASES*RONALD C. BISHOP, M.D., F.A.C.P., HERBERT H. SPENCER, M.D., FRANK H. BETHELL, M.D., F.A.C.P.The Quinidine ProblemQuinidine-induced thrombocytopenic purpura 1 July 1952Volume 37, Issue 1Page: 190-194KeywordsBloodPlateletsQuinine ePublished: 1 December 2008 Issue Published: 1 July 1952 PDF downloadLoading ...