THE RELIEF OF PEPTIC ULCER PAIN BY TETRAETHYL AMMONIUM CHLORIDE
Authors: P A BINTER, T J RANKIN
Journal: Annals of Internal Medicine (1950)

Article1 September 1950THE RELIEF OF PEPTIC ULCER PAIN BY TETRAETHYL AMMONIUM CHLORIDEPAUL A. BINTER, M.D., THOMAS J. RANKIN, M.D.PAUL A. BINTER, M.D.Search for more papers by this author, THOMAS J. RANKIN, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-33-3-649 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe promising application of vagotomy to the therapy of peptic ulcer has stimulated study of pharmacologic agents capable of depressing vagal activity. One such drug is the quaternary ammonium compound, tetraethyl ammonium chloride. In 1945 and 1946 Acheson and Moe,1, 2working with animals, demonstrated that the tetraethyl ammonium ion blocks transmission of nerve impulses through autonomic ganglia. Later, Lyons et al.3studied the effects of this blockade in man. One of these effects was the cessation of propulsive gastrointestinal motility as observed fluoroscopically with the barium meal. They noted that pain resulting from peptic ulcer was relieved following administration...Bibliography1. AchesonMoe GHGK: Some effects of tetraethylammonium on the mammalian heart, J. Pharmacol. and Exper. Therap. 84: 189-195, 1945. Google Scholar2. AchesonMoe GHGK: The action of the tetraethylammonium ion on mammalian circulation, J. Pharmacol. and Exper. Therap. 87: 220-236, 1946. MedlineGoogle Scholar3. LyonsMoeNelighHooblerCampbellBerryRennick RHGKRBSWKNRLBR: The effects of blockade of the autonomic ganglia in man with tetraethylammonium. Preliminary observations on its clinical application, Am. J. M. Sc. 213: 315-323, 1947. CrossrefMedlineGoogle Scholar4. HoltLyonsNelighMoeHodges JFRHRBGKFJ: X-ray signs of altered alimentary function following autonomic blockade with tetraethylammonium, Radiology 49: 603-610, 1947. CrossrefMedlineGoogle Scholar5. DoddsOuldDailey DCCLME: The effect of tetraethylammonium chloride on gastric motility in man, Gastroenterology 10: 1007-1009, 1948. MedlineGoogle Scholar6. BrownPoseyGambill HSELEE: Studies on the effect of tetraethylammonium chloride on gastric motor and secretory function in patients with duodenal ulcer, Gastroenterology 10: 837-847, 1948. MedlineGoogle Scholar7. Grenell RG: Howell's textbook on physiology, 1946, W. B. Saunders Co., Philadelphia, Ed. 15, pp. 227, 228. Google Scholar8. BestTaylor CHNB: The physiological basis of medical practice, 1945, The Williams and Wilkins Co., Baltimore, Ed. 4, pp. 489, 587, 943. Google Scholar9. BestTaylor CHNB: ibid, p. 447. Google Scholar10. BestTaylor CHNB: ibid, p. 447. Google Scholar11. BestTaylor CHNB: ibid, p. 516. Google Scholar12. SmithRuffinBaylin RCJMGJ: The effects of transthoracic vagus resection upon patients with peptic ulcer, South. M. J. 40: 1-10, 1947. CrossrefMedlineGoogle Scholar13. MooreChapmanSchulzJones FDWPMDCM: Transdiaphragmatic resection of vagus nerves for peptic ulcer, New England J. Med. 234: 241-251, 1946. CrossrefMedlineGoogle Scholar14. DragstedtOwens LRSM: Supra-diaphragmatic section of the vagus nerves in treatment of duodenal ulcer, Proc. Soc. Exper. Biol. and Med. 53: 152-154, 1943. CrossrefGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Wichita, Kansas*Received for publication August 17, 1948. (Presented in essence at the Kansas Regional Meeting of the American College of Physicians, 1949.)From the Medical Service of the Veterans Administration Hospital, Wichita, Kansas; and the College of Medicine, University of Kansas.Published with the permission of the Chief Medical Director, Department of Medicine and Surgery, Veterans Administration, who assumes no responsibility for the opinions expressed or the conclusions drawn by the authors. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byFURTHER OBSERVATIONS ON THE MECHANISM OF ULCER PAIN*†‡E. CLINTON TEXTER JR., M.D., F.A.C.P., GASTON R. VANTRAPPEN, M.D., HAROLD P. LAZAR, M.D., ERNESTO J. PULETTI, M.D., CLIFFORD J. BARBORKA, M.D., F.A.C.P.Treatment of Peptic UlcerMechanism of Pain in Peptic UlcerDie Krankheiten des MagensGeneral abstracts 1 September 1950Volume 33, Issue 3Page: 649-658KeywordsAction potentialsChloridesDrugsGangliaGastrointestinal motility disordersHospital medicineMedical servicesPeptic ulcersSurgeryVagotomy ePublished: 1 December 2008 Issue Published: 1 September 1950 PDF downloadLoading ...