Alkali-resistant Hemoglobin in Sickle Cell Disease
Authors: J N Bickers
Journal: Annals of Internal Medicine (1966)

Article1 May 1966Alkali-resistant Hemoglobin in Sickle Cell DiseaseJOHN N. BICKERS, M.D.JOHN N. BICKERS, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-64-5-1028 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptA substantial percentage of patients with homozygous hemoglobin S disease produce detectable amounts of alkali-resistant hemoglobin* during their adult life. The alkali-resistant hemoglobin lacks the pathologic physical properties of hemoglobin S; thus, the capacity to produce alkali-resistant hemoglobin is of potential importance as a source of functionally normal hemoglobin in sickle cell disease. The recognition of factors that affect alkali-resistant hemoglobin production may provide insight into the basic mechanisms that control its synthesis.The literature contains remarkably little information on the natural history of alkali-resistant hemoglobin in sickle cell disease and even less concerning the variables that affect its production....References1. SINGERCHERNOFFSINGER HAJL: Studies on abnormal hemoglobin. I. Their demonstration in sickle cell anemia and other hematologic disorders by means of alkali denaturation. Blood 6: 413, 1951. CrossrefMedlineGoogle Scholar2. BEAVENELLISWHITE GHMJJC: Studies on human foetal haemoglobin. III. The hereditary haemoglobinopthies and thalassaemias. Brit. J. Haemat. 7: 169, 1961. CrossrefMedlineGoogle Scholar3. JACKSONODOMBELL JFJLWM: Amelioration of sickle cell disease by persistent fetal hemoglobin. JAMA 177: 867, 1961. CrossrefMedlineGoogle Scholar4. 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Author, Article, and Disclosure InformationAffiliations: New Orleans, LouisianaFrom the Department of Medicine, Louisiana State University School of Medicine, New Orleans, La.This study was supported by a grant from the Cancer Association of Greater New Orleans, Inc., and by grant FR 5376 to the Louisiana State University from the National Institutes of Health, Bethesda, Md.Requests for reprints should be addressed to John N. Bickers, M.D., 1542 Tulane Ave., New Orleans, La. 70012.*The designation "alkali-resistant hemoglobin" is used in preference to fetal hemoglobin or hemoglobin F, although they are commonly used interchangeably. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byFetal hemoglobin and the irreversibly sickled cell in sickle cell diseasePregnancy in sickle-cell anemia in a Caucasian groupCholelithiasis in sickle cell anemia in a caucasian populationFetal and embryonic haemoglobins.Chemical heterogeneity of fetal hemoglobin in subjects with sickle cell anemia, homozygous hb-c disease, sc-disease, and various combinations of hemoglobin variantsHomozygous sickle cell disease with coexistent hereditary spherocytosis in three siblingsNormal and Abnormal Human HemoglobinsInherited disorders of hemoglobin synthesis and pregnancyHemoglobinopathic dysfunction of the red cell 1 May 1966Volume 64, Issue 5Page: 1028-1033KeywordsBiostatisticsHemoglobinHormonesSickle cell disease ePublished: 1 December 2008 Issue Published: 1 May 1966 PDF downloadLoading ...