tbuckley/cabot-search huggingface dataset:
Colchicine in acute gout: Low dose colchicine was started after usual dose
Authors: G Sivagnanam
Journal: BMJ (2004)

EDITOR—Morris et al emphasise that in acute gout lower doses of colchicine are effective yet less toxic than traditional regimens.1 Certain points need, however, to be considered.

In all the three cases quoted the patients initially started taking higher (traditional) doses of colchicine and only after they had experienced adverse …
Effect of adrenergic agents and phorbol esters on phosphorylation of sarcolemmal proteins in beating guinea pig hearts
Authors: I. Edes, L. Talosi, E. G Kranias
Journal: Cardiovascular Research (1991)

The aim was to determine whether activation of protein kinase C by alpha adrenergic agonists or phorbol esters would be associated with increased phosphorylation of the 15 kDa sarcolemmal protein in guinea pig hearts.Intact, beating guinea pig hearts were perfused with modified Krebs-Henseleit buffer containing [32P]Pi and freeze clamped in a control condition or at the peak of the inotropic response to noradrenaline. Membrane vesicles enriched in sarcolemma were isolated and then subjected to SDS polyacrylamide gel electrophoresis and autoradiography. Phosphorylated proteins were identified and 32P incorporation was quantitated. In some cases, hearts were perfused with phorbol 12-myristate, 13-acetate, or dioctanoyl-glycerol, which are known to be potent activators of protein kinase C. EXPERIMENTAL PREPARATIONS: Whole hearts from 55 anaesthetised guinea pigs weighing 500-600 g were used.Perfusion of guinea pig hearts with noradrenaline resulted in increases in contractility and tissue inositol 1,4,5-triphosphate levels, but there were no increases in the phosphorylation of the 15 kDa sarcolemmal protein observed. Furthermore, perfusion with phorbol 12-myristate, 13-acetate, or dioctanoylglycerol failed to stimulate the phosphorylation of the 15 kDa sarcolemmal protein.These data indicate that the 15 kDa sarcolemmal protein, which may be phosphorylated by protein kinase C in vitro, is not a substrate for the same enzyme in beating guinea pig hearts.
Abstract P5-01-12: Prognostic implications of tumor-infiltrating lymphocytes (TIL) in association with PD-L1 expression, and serum cytokine levels in early breast cancer
Authors: IH Park, S-Y Kong, JY Ro, Y Kwon, JH Kang, HJ Mo, S-Y Jung, S Lee, KS Lee, H-S Kang, E Lee, J Ro
Journal: Cancer Research (2013)

Abstract Background Immune system has been known to influence the prognosis of breast cancer (BC). However, the relationship between immune modulating factor (PD-L1) and tumor infiltrating lymphocyte (TIL) profiles in breast cancer has yet to be revealed according to breast cancer subtypes. In addition, the effects of circulating cytokines on TILs have not been addressed. Patients and methods We investigated the relationship between the profiles of TILs and PD-L1 expression of the primary tumor tissue by immunohistochemistry with clinical outcomes in 253 patients who underwent surgery for early breast cancer at National Cancer Center from January 2001 to December 2005. Besides, the serum cytokines including IL-10, IL-18, IL-6, IFN-g, and TGF-β1 were measured at diagnosis. Clinical data including hormone receptors status, HER2 expression, disease free survival (DFS), and overall survival (OS) were collected. Results Median age of patients was 49 years (range, 32-74) and median follow-up was 8.5 years. One hundred eighty five (73.1%) patients had hormone receptor (HR) positive and 101 (39.9%) patients had node positive BC. CD8+ TILs were more abundant in low PD-L1 expressed tumor (P = 0.027), though there was no association between FOXP3+ TILs and PD-L1 expression (P = 0.585). A total number of TILs was higher in HR negative compared with HR positive BC (P = 0.061) and the expression of PD-L1 was more frequent in HR positive BC (P&amp;lt;0.001). In HR negative BC, there was a trend of longer DFS in patients with higher CD8+ TILs and low PD-L1 expression (P = 0.097). However, such association was not detected in HR positive BC patients. Among serum cytokines we examined, the higher levels of IL-18 were significantly associated with shorter DFS in HR negative BC (P = 0.006). In HR negative BC, higher CD8+ TILs with low PD-L1 expression and lower IL-18 were significantly related with better clinical outcomes when adjusted with other clinical factors (DFS, P = 0.032; OS, P = 0.048). Conclusions Lower PD-L1 expression in breast tumor was associated with higher CD8+ lymphocyte infiltration. Especially in HR negative BC, increasing CD8+ TILs with lower PD-L1 expression and lower serum IL-18 level were good prognostic factors. Further validation will be needed to establish the role of immune profiles in BC patients. Citation Information: Cancer Res 2013;73(24 Suppl): Abstract nr P5-01-12.
Consultants are closer to pay deal after winning concessions
Authors: A. Gulland
Journal: BMJ (2003)

Consultants could be voting on a new contract by the autumn, after senior doctors secured important concessions from the government last week.

A special meeting of the BMA's consultants' committee will be called next month to discuss the package. If the committee agrees to the package, consultants will be balloted in early September.

Paul Miller, chairman of the Central Consultants and Specialists Committee, said the biggest gains were that control over doctors by managers would be reduced, new consultants would be on the same contract as longer serving colleagues, a structure for an appeal panel had been worked out, and work …
TREATMENT OF PUERPERAL INFECTIONS
Authors: B. P. Watson
Journal: BMJ (1923)

TREATMENT' OTUfltPERAL IN-FECTONS.[X JO__ 5°5 about by heightened arteriaLl tension.This theory Iturns rather-on causes than processes; in its distinction between stimulation and irritation it has been considered in the review of Jores'g theory, and in its refereice to primary weakening of the media it comes under Thoma's theory of arterio-selerosis.Lastly, the lesion in arterio-sclerosis has been compared to keloid, and though he does not make this comparison OphU1is7 approaches this hypothesis in his refer- ence to the autochthonous development of arterio-sclerosis.If simpler pathological conceptions fail it may be necessary to have recourse to the complicated explanations offered by the terms " productive fibroses," "fibrous diathesis," and "autochthonus development," but in the meantime I am of the opinion that the simple process of inflammation ig suffi- cient explanation of the production of the lesion in diffuse hyperplastic sclerosis, and in the next and last lecture its activity in other forms of arterio-sclerosis will be considered.
Vascular Calcification in Chronic Renal Failure
Authors: Ellen Neven, Patrick C. D'Haese
Journal: Circulation Research (2011)

Accelerated atherosclerotic plaque calcification and extensive medial calcifications are common and highly detrimental complications of chronic kidney disease. Valid murine models have been developed to investigate both pathologically distinguishable complications, which allow for better insight into the cellular mechanisms underlying these vascular pathologies and evaluation of compounds that might prevent or retard the onset or progression of vascular calcification. This review describes various experimental models that have been used for the study of arterial intimal and/or medial calcification and discusses the extent to which this experimental research has contributed to our current understanding of vascular calcification, particularly in the setting of chronic renal failure.
European Ancestry as a Risk Factor for Atrial Fibrillation in African Americans
Authors: Gregory M. Marcus, Alvaro Alonso, Carmen A. Peralta, Guillaume Lettre, Eric Vittinghoff, Steven A. Lubitz, Ervin R. Fox, Yamini S. Levitzky, Reena Mehra, Kathleen F. Kerr, Rajat Deo, Nona Sotoodehnia, Meggie Akylbekova, Patrick T. Ellinor, Dina N. Paltoo, Elsayed Z. Soliman, Emelia J. Benjamin, Susan R. Heckbert
Journal: Circulation (2010)

Despite a higher burden of standard atrial fibrillation (AF) risk factors, African Americans have a lower risk of AF than whites. It is unknown whether the higher risk is due to genetic or environmental factors. Because African Americans have varying degrees of European ancestry, we sought to test the hypothesis that European ancestry is an independent risk factor for AF.
CORTISONE THERAPY IN ULCERATIVE COLITIS
Authors: G. Malcolm Brown
Journal: JAMA (1952)

Reports are now available on the results of cortisone therapy in small groups of patients with ulcerative colitis. Dearing and Brown<sup>1</sup>treated four patients with small dosages and induced a remission in one. Kirsner, Palmer, and Klotz<sup>2</sup>treated five patients with chronic ulcerative colitis and found definite though gradual improvement in two, rapid improvement in one but with early and refractory remission, no response in one, and in another a poorer response than was subsequently seen with corticotropin (ACTH). Halsted and associates<sup>3</sup>treated four patients with cortisone dosages up to 250 mg. per day to a total of 2,600 mg. and had excellent results in one and slight improvement in two. Redish<sup>4</sup>saw no improvement in two patients with chronic cases in acute exacerbation treated with dosages of 100 to 200 mg. over 10 day periods but did see slight improvement in two of three patients
The archeology of internalism
Authors: Martin Kurthen
Journal: Behavioral and Brain Sciences (2001)

Behavioral regularities are open to both representationist (hence internalist) and non-representationist explanations. Shepard improvidently favors internalism, which is burdened with severe conceptual and empirical shortcomings. Hecht and Kubovy &amp; Epstein half-heartedly criticize internalism by tracing it back to “unconscious” metaphors or by replacing it with weak externalism. Explanations of behavioral regularities are better relocated within a radical embodiment approach. [Hecht; Kubovy &amp; Epstein; Shepard]
Is the Prevalence of Peanut Allergy Increasing? A Five-year Follow-up Study on the Prevalence of Peanut Allergy in Montreal School Children Aged 5 to 9 Years
Authors: M BENSHOSHAN, R KAGAN, R ALIZADEHFAR, L JOSEPH, E TURNBULL, Y STPIERRE, A CLARKE
Journal: Journal of Allergy and Clinical Immunology (2008)
Effect of a Self-care Education Program on Medical Visits
Authors: Donald M. Vickery
Journal: JAMA (1983)

A prospective, randomized, controlled trial of self-care educational interventions was conducted in a health maintenance organization to determine their effect on ambulatory care utilization. Statistically significant decreases in total medical visits and minor illness visits were found in each of three experimental groups as compared with a control group. These decreases averaged 17% and 35%, respectively. These results were most clearly linked to a system of written communications emphasizing personal decision making about the use of medical care. The addition of a nurse counseling session to the written materials may increase cost savings and appears to be attractive to "high utilizers." A telephone information service was offered but not used. It is estimated that the decreases in utilization could result in a savings of approximately $ 2.50 to $ 3.50 for each dollar spent ona nurse counseling session to the written materials may increase cost savings and appears to be attractive to "high utilizers." A telephone information service was offered but not used. It is estimated that the decreases in utilization could result in a savings of approximately $ 2.50 to $ 3.50 for each dollar spent on the educational interventions. Self-care education systems may have important effects on medical care costs, physician satisfaction, and patient confidence.
Interleukin-8 as a Stratification Tool for Interventional Trials Involving Pediatric Septic Shock
Authors: Hector R. Wong, Natalie Cvijanovich, Derek S. Wheeler, Michael T. Bigham, Marie Monaco, Kelli Odoms, William L. Macias, Mark D. Williams
Journal: American Journal of Respiratory and Critical Care Medicine (2008)

Interventional clinical trials involving children with septic shock would benefit from an efficient preenrollment stratification strategy.To test the predictive value of interleukin (IL)-8 for 28-day mortality in pediatric septic shock.A training data set (n = 40) identified a serum IL-8 of greater than 220 pg/ml as having a 75% sensitivity and specificity for predicting 28-day mortality. This cutoff was then subjected to a series of validation steps.Subjects were drawn from two large, independent pediatric septic shock databases. Prospective application of the IL-8 cutoff to validation data set 1 (n = 139) demonstrated 78% sensitivity and 64% specificity for 28-day mortality. A serum IL-8 level of 220 pg/ml or less, however, had a negative predictive value for 28-day mortality of 95% in validation data set 1, which was subsequently applied to an independently generated data set of children with septic shock (validation set 2, n = 193). A serum IL-8 level of 220 pg/ml or less had a negative predictive value for 28-day mortality of 94% when applied to validation set 2.A serum IL-8 level of 220 pg/ml or less, obtained within 24 hours of admission, predicts a high likelihood of survival in children with septic shock. We propose that IL-8 can be used to exclude such patients from interventional clinical trials and ultimately derive a study population with a more favorable risk to benefit ratio when subjected to a study agent.
Extensive admixture in Brazilian sickle cell patients: implications for the mapping of genetic modifiers
Authors: Maria Clara F. da Silva, Luciana W. Zuccherato, Flavia C. Lucena, Giordano B. Soares-Souza, Zilma M. Vieira, Sérgio D.J. Pena, Marina L. Martins, Eduardo Tarazona-Santos
Journal: Blood (2011)
Spontaneous Intramural Perforation of the Esophagus: Case Report and Review of the Literature
Authors: Yow-Chii Kuo, Cheng-Shyoung Wu
Journal: Endoscopy (1989)

A 47-year-old male suffered spontaneous intramural perforation of his esophagus following tracheostomy and nasogastric intubation. The reports of this unusual lesion in the literature are reviewed, and the characteristic radiographic and endoscopic features demonstrated.
The Case Against Criminalization of HIV Transmission
Authors: Scott Burris
Journal: JAMA (2008)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
TCT-508 Optimal Medical Treatment in Patients with Hypertension Undergoing Primary Percutaneous Coronary Intervention for Acute Myocardial Infarction
Authors: Doo Sun Sim, Myung Ho Jeong, Youngkeun Ahn, Shung Chull Chae, Young Jo Kim, Chong Jin Kim, Myeong Chan Cho, Ki Bae Seung
Journal: Journal of the American College of Cardiology (2012)
Coronary-Prone Behavior Patterns
Authors: C. David Jenkins
Journal: JAMA (1974)

To the Editor.—  The letter by Dr. Ernest H. Friedman (228:1369, 1974) contains misleading statements and thus warrants clarification. Dr. Friedman has seriously misinterpreted our paper, Toward a Redefinition of the Coronary-Prone Behavior Pattern: Inferences from Test Items Which Predict Future Coronary Disease, presented at the meeting of the American Psychosomatic Society in Philadelphia, March 31, 1974.  The basic message of that paper was that the coronary-prone behavior pattern, type A, as described by Dr. Meyer Friedman and Dr. Ray H. Rosenman, is associated prospectively with all types of coronary heart disease both as measured by the structured interview for type A and the Activity Survey, a self-administered, computer-scored test. Readers are referred to a recent article inThe New England Journal of Medicine(290: 1271, 1974) for further documentation of our position.  The paper presented in Philadelphia went beyond this general finding by means of item analysis of the computer-scored
Biodegradable in situ gelling system for subcutaneous administration of ellagic acid and ellagic acid loaded nanoparticles: Evaluation of their antioxidant potential against cyclosporine induced nephrotoxicity in rats
Authors: G. Sharma, J.L. Italia, K. Sonaje, K. Tikoo, M.N.V. Ravi Kumar
Journal: Journal of Controlled Release (2006)
Connective Tissue Diseases
Authors: J. D. Perry
Journal: Annals of the Rheumatic Diseases (1978)

consecutive occasions by 5-day courses of intravenously not granted.administered cytosine arabinoside 100 mg/day.These data provide further evidence of the beneficial This patient was followed by us for a further period of effect of cytosine arabinoside in the symptomatic treat-22 months.During that time, while the haematological ment of patients with this condition.picture remained unchanged, he suffered from eleven episodes of excrutiating bone pain, always responsive to J. AsHEROV, Y. SHOENFELD, and J. PKHAS the same treatment.Repeated skeletal x-rays and bone Department of Medicine 'D', scans showed no osteolytic lesions.In December 1977 a
Observations on ASTHMA: RESULTS OF TREATMENT
Authors: D. M. Lyon, R. M. Murray-Lyon
Journal: BMJ (1930)

RESULTS OF TREATMENT.[MDCLJDIN1 8 occas;ionlal attacks, and these u-sually miild in chiaracter.~~Ob~~er~~ations ~~Th-e, tlhird jclass-.thosemuchel im-iprov'e'd
Further Experience with Epigastric Pain Reproduction Test in Duodenal Ulceration
Authors: R. J. Earlam
Journal: BMJ (1972)

Further evidence is presented that the epigastric pain of duodenal ulceration, situated between the rib margins and just below the xiphisternum, arises from the lower oesophagus.One-hundred patients with duodenal ulceration were divided into those with epigastric pain (61) and those with pain in the upper abdomen but not in the epigastrium (39). Perfusion of 0.1 N HCl into the lower oesophagus reproduced epigastric pain in 53 of the 61 with epigastric pain (mean 37 ml) but in none of the 39 without (mean 125 ml). All those who had been woken by epigastric pain at night in the previous four weeks had a positive test.In five the test remained positive even though the acid was neutralized by a continuous perfusion of alkali just below the gastro-oesophageal junction. In another five 200 ml 0.1 N HCl instilled into the stomach for 21 minutes did not reproduce epigastric pain, even though 30 ml perfused for three minutes into the lower oesophagus did.
Is avoidant coping independent of disease status and stable over time in patients with ankylosing spondylitis?
Authors: A Boonen, D van der Heijde, R Landewe, A Chorus, W van Lankveld, H Miedema, H van der Tempel, S van der Linden
Journal: Annals of the Rheumatic Diseases (2004)

To determine whether avoidant coping in ankylosing spondylitis (AS) is independent of disease status and whether it is stable over time.658 patients with AS completed a postal questionnaire on health status, including pain and stiffness (BASDAI), physical function (BASFI), and coping (CORS). In CORS, "decreasing activities to cope with pain" and "pacing to cope with limitations" reflect avoidant behavioural coping. Ninety patients continued in a longitudinal study and 70 completed the CORS after four years. The adjusted contribution of age, sex, disease duration, educational level, pain (BASDAI), and physical function (BASFI) to the two avoidant coping strategies at first assessment was determined by multiple linear regression. Agreement between coping at first assessment and four years later was determined by intraclass correlation, and the correlation between change in coping and change in disease status over time by Pearson's correlation.At first assessment, worse physical function (BASFI) and more pain (BASDAI) were associated with "decreasing activities to cope with pain". Worse physical function, but not pain, was associated with "pacing to cope with limitations". The contribution of physical function or pain to the total explained variance in each of the coping strategies was small. Disease duration was not a determinant of avoidant coping, but greater age was associated with "pacing to cope with limitations". Change in avoidant coping strategies over time could not be explained by change in function or pain.In AS, avoidant coping at a particular time is largely independent of disease duration or status. Variability in avoidant coping over a limited period of four years cannot be explained by change in disease status.
Re-entrant ventricular arrhythmias in the late myocardial infarction period. 5. Mechanism of action of diphenylhydantoin.
Authors: N El-Sherif, R Lazzara
Journal: Circulation (1978)

The mechanism of action of diphenylhydantoin (DPH) on re-entrant ventricular arrhythmias (RVA) was studied in dogs 3-7 days following ligation of the anterior descending coronary artery utilizing direct recordings of the re-entrant pathway (RP) from the epicardial surface of the infarction zone (IZ). DPH in a therapeutic dose consistently prolonged refractoriness of potentially RP in the IZ. This resulted in further impairment and/or block of conduction in the RP and was directly responsible for DPH ability to abolish RVA. On the other hand, DPH had no significant effect on conduction in the adjacent normal zone. Prior to abolition of RVA initiated by premature beats (PBs), DPH resulted in: 1) narrowing of the critical range of coupling intervals of PBs that resulted in re-entry (i.e., the re-entry zone), 2) shift of the narrowed re-entry zone to longer cardiac cycle lengths, and 3) lengthening of the coupling interval of the first re-entrant beat, as well as slowing the rate of re-entrant tachycardia. Thus DPH, similar to lidocaine, owes its antiarrhythmic action in RVS to its selective depressant effect on ischemic cells forming part of the RP.
CLINICAL AND ECHOCARDIOGRAPHIC FACTORS ASSOCIATED WITH NEW-ONSET ATRIAL FIBRILLATION IN PATIENTS WITH HEART FAILURE AND SINUS RHYTHM: A SUB-ANALYSIS OF THE WARCEF TRIAL
Authors: Tomoko S. Kato, Marco Di Tullio, Min Qian, Mengfei Wu, John L.P. Thompson, Shunichi Homma
Journal: Journal of the American College of Cardiology (2014)
Annotated Answers to the 1902 Examination on Osler's Principles and Practice of Medicine
Authors: W. D. TIGERTT
Journal: Annals of Internal Medicine (1973)

In the 1926 Classified and Annotated Bibliography of the Publications of Sir William Osler (1) Garrison, under the rubric of Osler's Principles and Practice of Medicine, made the following entry: "The clear, concise, attractive presentation and the many citations from history and the classics gave it an unique place among scientific books with an essentially literary flavor. A humorous 'examination paper' on the recondite literary allusions in Osler's Practice was published in St. Thomas' Hospital Gazette, Lond., 1902, xii, 59. . . ." In an earlier comment, in the same vein, Garrison (2) used the term "burlesque" to describe the