Hypercholesterolemia Persisting After Distal Ileal Bypass: Response to Mevinolin
Authors: D. ROGER ILLINGWORTH
Journal: Annals of Internal Medicine (1984)

Brief Reports1 June 1984Hypercholesterolemia Persisting After Distal Ileal Bypass: Response to MevinolinD. ROGER ILLINGWORTH, M.D., Ph.D., WILLIAM E. CONNOR, M.D.D. ROGER ILLINGWORTH, M.D., Ph.D.Search for more papers by this author, WILLIAM E. CONNOR, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-100-6-850 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptFamilial hypercholesterolemia is an autosomal dominant disorder associated with lifelong hypercholesterolemia and premature atherosclerosis (1). Treatment of patients heterozygous for this disorder has included diet, medications (colestipol, nicotinic acid, probucol) (2), and in certain patients surgical bypass of the distal ileum (3). By selectively removing the site of bile acid reabsorption, distal ileal bypass surgery results in enhanced fecal excretion of bile acids; an increased rate of hepatic conversion of cholesterol to bile acids; and, by depleting the hepatic pool of cholesterol, an increase in the number of high-affinity receptors for low-density lipoproteins (LDL) on hepatocyte membranes with a concomittant...References1. BROWNGOLDSTEIN MJ. Familial hypercholesterolemia: genetic, biochemical and pathological considerations. Adv Intern Med. 1975;20:273-96. MedlineGoogle Scholar2. HAVELKANE RJ. Therapy of hyperlipidemic states. Annu Rev Med. 1982;33:417-33. CrossrefMedlineGoogle Scholar3. SPENGELJADHAVDUFFIELDWOODTHOMPSON FARCG. Superiority of partial ileal bypass over cholestyramine in reducing cholesterol in familial hypercholesterolemia. Lancet. 1981;2:768-70. CrossrefMedlineGoogle Scholar4. MIETTINENLEMPINEN TM. Cholestyramine and ileal by-pass in the treatment of familial hypercholesterolemia. Eur J Clin Invest. 1977;7:509-14. CrossrefMedlineGoogle Scholar5. TOBERTBELLBIRTWELL JGJ. Cholesterol-lowering effect of mevinolin, an inhibitor of 3-hydroxy-3-methylglutaryl coenzyme A reductase, in healthy volunteers. J Clin Invest. 1982;69:913-9. CrossrefMedlineGoogle Scholar6. MABUCHIHABATATAMI HTR. Effects of an inhibitor of 3-hydroxy-3-methylglutaryl coenzyme A reductase on serum lipoproteins and ubiquinone-10 levels in patients with familial hypercholesterolemia. N Engl J Med. 1981;305:478-82. CrossrefMedlineGoogle Scholar7. MABUCHISAKAISAKAI HTY. Reduction of serum cholesterol in heterozygous patients with familial hypercholesterolemia: additive effects of compactin and cholestyramine. N Engl J Med. 1983;308:609-13. CrossrefMedlineGoogle Scholar8. ILLINGWORTH D. Mevinolin in the therapy of heterozygous familial hypercholesterolemia [Abstract]. Circulation. 1983;68:111-188. Google Scholar9. BILHEIMERGRUNDYBROWNGOLDSTEIN DSMJ. Mevinolin and colestipol stimulate receptor-mediated clearance of low density lipoprotein from plasma in familial hypercholesterolemia heterozygotes. Proc Natl Acad Sci USA. 1983;80:4124-8. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: The Oregon Health Sciences University Portland, Oregon PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByTherapie von FettstoffwechselstörungenHypercholesterolemia and atherosclerosis: Present and future therapy including LDL-apheresisTherapie von FettstoffwechselstörungenHypolipidemic effects of HMG-CoA reductase inhibitors in patients with hypercholesterolemiaInfluence of Combined Therapy with Mevinolin and Interruption of Bile-Acid Reabsorption on Low Density Lipoproteins in Heterozygous Familial HypercholesterolemiaSCOTT M. GRUNDY, M.D., Ph.D., GLORIA LENA VEGA, Ph.D., DAVID W. BILHEIMER, M.D. 1 June 1984Volume 100, Issue 6Page: 850-851KeywordsBileCareers in researchCholesterolIleumLipoprotein receptorsLow density lipoproteinMedical servicesNiacinPatientsSurgery Issue Published: 1 June 1984 PDF DownloadLoading ...