PATHOGENESIS OF RHEUMATIC FEVER
Authors: W J KERR
Journal: Annals of Internal Medicine (1948)

Article1 October 1948PATHOGENESIS OF RHEUMATIC FEVERWM. J. KERR, M.D., F.A.C.P.WM. J. KERR, M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-29-4-587 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptRheumatic fever is one of our most serious diseases. It attacks children primarily but under conditions of crowding, exposure, and fatigue, may affect older age groups in certain localities as was demonstrated in the recent war. The late manifestations of the disease are so disabling that they produce our most serious medical economic and social problems in the prime of life for those so afflicted.There is abundant evidence that microörganisms of thestreptococcus groupare the etiological agents which initiate a train of reactions in the host resulting in the lesions characteristic of the disease. It is not proved...Bibliography1. CHANDLERTAUSSIG CAHB: Sulfanilamide as prophylactic agent in rheumatic fever, Bull. Johns Hopkins Hosp., 1943, lxxii, 42. Google Scholar2. SWIFT HF: Rheumatic fever, Hektoen Lecture, Billings Foundation, Jr. Am. Med. Assoc., 1929, xcii, 2071. CrossrefGoogle Scholar3. RICHGREGORY ARJE: Experimental evidence that lesions with the basic characteristics of rheumatic carditis can result from anaphylactic hypersensitivity, Bull. Johns Hopkins Hosp., 1943, lxxiii, 239. Google Scholar4. RICHGREGORY ARJE: Further experimental cardiac lesions of the rheumatic type produced by anaphylactic hypersensitivity, Bull. Johns Hopkins Hosp., 1944, lxxv, 115. Google Scholar5. RICH AR: The role of hypersensitivity in the pathogenesis of rheumatic fever and periarteritis nodosa, Proc. Inst. Med. Chicago, 1945, xv, 270. Google Scholar6. MASUGISATOTODO MYS: Über die Veranderungen des Herzens durch das spezifische Antiherzserum: Experimentelle Untersuchungen über die allergischen Gewebsschaden des Herzens, Trans. Japan. Path. Soc., 1931, xxi, 329. Google Scholar7. MASUGI M: Über das Wesen der spezifischen Veranderungen der Niere und der Leber durch das Nephrotoxin bzw. das Hepatotoxin, Beitr. z. path. Anat. u. z. allg. Path., 1933, xci, 82. Google Scholar8. MASUGI M: Über die experimentelle Glomerulonephritis durch das spezifische Antinierenserum, Beitr. z. path. Anat. u. z. allg. Path., 1934, xcii, 429. Google Scholar9. BAUER FC: Reaction of rats following injection of anti-rat heart immune serum, Arch. Path., 1946, xlii, 222. Google Scholar10. BURKY EL: Production in rabbit of hypersensitive reactions to lens, rabbit muscle and low ragweed extracts by action of Staphylococcus aureus , Jr. Allergy, 1933-34, v, 466. Google Scholar11. SCHWENTKERCOMPLOIER FFFC: Production of kidney antibodies by injection of homologous kidney plus bacterial toxins, Jr. Exper. Med., 1939, lxx, 223. CrossrefGoogle Scholar12. HECHTSULZBERGERWEIL RMBH: Studies in sensitization to skin. I. Production of antibodies to skin by means of synergistic action of homologous skin antigen and staphylococcus toxin, Jr. Exper. Med., 1943, lxxviii, 59. CrossrefGoogle Scholar13. CAVELTICAVELTI PAES: Studies on the pathogenesis of glomerulonephritis. I. Production of auto-antibodies to kidney in experimental animals, Arch. Path., 1945, xxxix, 148. Google Scholar14. CAVELTICAVELTI PAES: Studies on the pathogenesis of glomerulonephritis. II. Production of glomerulonephritis in rats by means of auto-antibodies to kidneys, Arch. Path., 1945, xl, 158. Google Scholar15. CAVELTICAVELTI PAES: Studies on the pathogenesis of glomerulonephritis. III. Clinical and pathological aspects of the experimental glomerulonephritis produced in rats by means of auto-antibodies to kidney, Arch. Path., 1945, xl, 103. Google Scholar16. CAVELTI PA: Studies on the pathogenesis of rheumatic fever. I. Production of auto-antibodies to heart, skeletal muscle, and connective tissue in experimental animals, Arch. Path., 1947, xliv, 1. Google Scholar17. CAVELTI PA: Studies on the pathogenesis of rheumatic fever. II. Cardiac lesions produced in rats by means of auto-antibodies to heart and connective tissue, Arch. Path., 1947, xliv, 13. Google Scholar18. CAVELTI PA: Studies on the technic of collodion agglutination, Jr. Immunol., 1944, xlix, 365. Google Scholar19. CAVELTI PA: The technic of collodion particle agglutinations, Jr. Immunol., 1947, lvii, 141. Google Scholar20. CAVELTI PA: Studies on the pathogenesis of glomerulonephritis and rheumatic fever: the activation of tissue antigens in vivo as a result of streptococcal infection and consecutive formation of auto-antibodies, Arch. Path., 1947, xliv, 119. Google Scholar21. CAVELTI PA: Auto-antibodies in rheumatic fever, Proc. Soc. Exper. Biol. and Med., 1945, lx, 379. CrossrefGoogle Scholar22. KERRCAVELTI WJPA: New immunologic aspects of the pathogenesis of glomerulonephritis and rheumatic fever, Trans. Assoc. Am. Phys., 1947, lx, 264. Google Scholar23. KLEMPERER P: The pathogenesis of lupus erythematosus and allied conditions, Ann. Int. Med., 1948, xxviii, 1. Google Scholar24. COBURN AF: The factor of infection in the rheumatic state, 1931, The Williams & Wilkins Co., Baltimore. Google Scholar25. RINEHARTMETTIER JFSR: The heart valves and muscle in experimental scurvy with superimposed infection, Am. Jr. Path., 1934, x, 61. Google Scholar26. COBURNKAPP AFEM: Effect of salicylates on precipitation of antigen with antibody, Jr. Exper. Med., 1943, lxxvii, 173. CrossrefGoogle Scholar27. COBURN AF: Salicylate therapy in rheumatic fever; rational technique, Bull. Johns Hopkins Hosp., 1943, lxxiii, 435. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: San Francisco, California*Presented before the 29th Annual Session of the American College of Physicians, April 22, 1948, San Francisco, California.From the Division of Medicine, University of California Medical School, San Francisco, California. Nextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byNiere bei Tumoren, Blutkrankheiten und ParaproteinämienRheumatic Fever and the Haemolytic StreptococcusActive rheumatic carditis in patients over 40 years of ageRheumatic Fever in Airmen: Stigma Analysis with Some Controlled Observations on Convalescent Depression and ArthralgiasOral penicillin for children with rheumatic fever 1 October 1948Volume 29, Issue 4Page: 587-594KeywordsAge groupsChildrenFatigueLesionsPathogenesisRheumatic feverStreptococcus ePublished: 1 December 2008 Issue Published: 1 October 1948 Copyright & PermissionsCopyright, 1948 by The American College of PhysiciansPDF downloadLoading ...