PLASMA CREATININE CONCENTRATION AND CREATININE CLEARANCE IN CLINICAL WORK
Authors: H N HAUGEN, E M BLEGEN
Journal: Annals of Internal Medicine (1955)

Article1 October 1955PLASMA CREATININE CONCENTRATION AND CREATININE CLEARANCE IN CLINICAL WORKH. N. HAUGEN, E. M. BLEGENH. N. HAUGEN, E. M. BLEGENAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-43-4-731 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptOur reason for writing this paper is the wish to sum up salient points concerning the endogenous creatinine clearance with special regard to the utility of the test in routine clinical work. We intend to stress the differences in the requirements for a renal functional test suitable for research work and one fit for clinical routine. We will emphasize that this difference does not put any stamp of inferiority on the latter: it is here a question of utility.We also wish to describe our laboratory procedure, which secures reliable results with relatively simple equipment. Many who have wanted to...Bibliography1. BlegenHaugen EMHN: Blood urea, plasma "creatinine" and clearance determinations in renal insufficiency, J. Oslo City Hosp. 2: 198, 1952. Google Scholar2. BlegenHaugenAas EHNK: Endogenous "creatinine" clearance, Scandinav. J. Clin. and Lab. Invest. 1: 191, 1949. CrossrefGoogle Scholar3. BonsnesTaussky RWH: On the determination of creatinine by the Jaffé reaction, J. Biol. Chem. 158: 581, 1945. CrossrefGoogle Scholar4. BrodSirota JJH: The renal clearance of endogenous "creatinine" in man, J. Clin. Investigation 27: 645, 1948. CrossrefMedlineGoogle Scholar5. Hare RS: Endogenous creatinine in serum and urine, Proc. Soc. Exper. Biol. and Med. 74: 148, 1950. CrossrefMedlineGoogle Scholar6. Haugen HN: Glucose and acetone as sources of error in plasma "creatinine" determinations, Scandinav. J. Clin. and Lab. Invest. 6: 17, 1954. MedlineGoogle Scholar7. Haugen HN: The determination of endogenous "creatinine" in plasma and urine, Scandinav. J. Clin. and Lab. Invest. 5: 48, 1953. 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Author, Article, and Disclosure InformationAffiliations: Oslo,*Received for publication March 19, 1955.From the Oslo City Hospitals, Department Krohgstotten, Oslo, Norway.†In this paper creatinine denotes the endogenous substances which yield color with alkaline picrate ("Jaffé-positive substances"). PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byEstimated GFR. 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