tbuckley/cabot-search huggingface dataset:
The role of intracoronary thrombus in unstable angina: angiographic assessment and thrombolytic therapy during ongoing anginal attacks.
Authors: K Gotoh, T Minamino, O Katoh, Y Hamano, S Fukui, M Hori, H Kusuoka, M Mishima, M Inoue, T Kamada
Journal: Circulation (1988)

Intracoronary thrombus is regarded as a potentially important factor in the etiology of unstable angina, but the incidence of intracoronary thrombus in unstable angina has not been clearly defined. To determine the occurrence of intracoronary thrombus during ongoing angina pectoris, coronary angiography was performed during spontaneous ischemic attacks in 37 patients with prolonged rest angina. All patients exhibited significant (greater than 50%) stenoses of at least one major coronary artery. Of the 37 patients, 21 (57%) had intracoronary thrombus in major coronary arteries, whereas 14 (38%) had fixed narrowings without evidence of intracoronary thrombus and two exhibited coronary spasm. ST segment elevation was observed in 16 of 21 patients with thrombus and in all of the patients with coronary spasm, but all the patients with organic stable obstruction showed ST segment depression. Twenty of the 21 patients with thrombus improved after thrombolytic therapy with intracoronary injection of urokinase; obstructed arteries were reopened, or narrowings were attenuated, with relief of ischemic symptoms. In patients with fixed obstructions, the rate-pressure product during active symptoms was significantly higher than during an asymptomatic period, indicating that a transient increase in myocardial oxygen demand may contribute to the ischemic attack in these patients. A high incidence (71%) of recurrent symptoms was observed in patients with intracoronary thrombus even after successful thrombolysis, in contrast to a much lower incidence (36%) in those without intracoronary thrombus. Myocardial infarction within 4 weeks after catheterization was observed more frequently in patients with intracoronary thrombus (24%) than in those without thrombus (7%).(ABSTRACT TRUNCATED AT 250 WORDS)
On the Protein Defect in Abetalipoproteinemia
Authors: Antonio M. Gotto, Robert I. Levy, Kathryn John, Donald S. Fredrickson
Journal: New England Journal of Medicine (1971)

Abstract The plasma lipoproteins from a patient with abetalipoproteinemia were delipidated and fractionated; the lipid-free proteins (apoproteins) were compared by physical, chemical and immunological technics with the apoproteins from normal subjects. It was established that the major protein constituents of the very low-density lipoproteins, other than apoLP-ser, and the two predominant proteins of the high-density lipoproteins are present in plasma in abetalipoproteinemia and are identical to the corresponding apoproteins from normal subjects. As previously shown, low-density lipoprotein (LDL) and its principal protein component (or components), here designated apoLP-ser, were not detected by immunological tests. These findings indicate that the primary biochemical lesion in abetalipoproteinemia is a selective one affecting the main apoprotein (or proteins) of LDL.
An Official Research Policy Statement of the American Thoracic Society/European Respiratory Society: Standards for Quantitative Assessment of Lung Structure
Authors: Connie C. W. Hsia, Dallas M. Hyde, Matthias Ochs, Ewald R. Weibel
Journal: American Journal of Respiratory and Critical Care Medicine (2010)

Keywords: morphometry; stereology; unbiased sampling; reference lung volume; cell volume; surface area; cell size; cell number; in vivo imaging
Microfluidic assisted one-step fabrication of porous silicon@acetalated dextran nanocomposites for precisely controlled combination chemotherapy
Authors: Dongfei Liu, Hongbo Zhang, Ermei Mäkilä, Jin Fan, Bárbara Herranz-Blanco, Chang-Fang Wang, Ricardo Rosa, António J. Ribeiro, Jarno Salonen, Jouni Hirvonen, Hélder A. Santos
Journal: Biomaterials (2014)
Stress and the Practice of Medicine
Authors: Adam J. Krakowski
Journal: Psychotherapy and Psychosomatics (1984)

Stresses of medical practice, recognized as severe, do not increase physical morbidity and mortality of physicians but are known to have deleterious effects upon their mental well-being. This has been documented by a study of 100 physicians reported by the author previously. The hypothesis of motivation for the choice of medical profession as a vocation was explored from the point of view of personality vulnerability due to reaction formation to the fear of death and resulting compulsivity. In search of validity of vulnerability a study was undertaken on 50 lawyers residing in the same community as the studied physicians. A structured interview identical to the one used in the study of physicians was employed and computer analyzed. Results of this comparative study are reported in the current presentation.
Control of Postcardiac Surgical Tachycardias with Propranolol
Authors: JACK M. MATLOFF, STEVEN WOLFSON, RICHARD GORLIN, DWIGHT E. HARKEN
Journal: Circulation (1968)

Twenty-two patients manifesting arrhythmias refractory to conventional therapy have been treated with propranolol 1 to 19 days after cardiac surgery. Rapid control of ventricular response to supraventricular arrhythmias, abolition of ventricular irritability caused by digitalis excess, and frequent conversion of acute atrial fibrillation or flutter were attained. Control of the arrhythmia was achieved in all but one instance. No significant side effects were encountered, although the potential risks of propranolol are stressed. Propranolol appears to fill specific needs unsatisfied by standard therapy for arrhythmias developing after cardiac surgery.
Salmonellosis in Patients with Neoplastic Disease.
Authors: Donald Armstrong
Journal: Annals of Internal Medicine (1968)

s1 May 1968Salmonellosis in Patients with Neoplastic Disease.Donald Armstrong, M.D., Martin S. Wolfe, M.D., Donald B. Louria, M.D., F.A.C.P., Anne Blevins, R.N.Donald Armstrong, M.D.Search for more papers by this author, Martin S. Wolfe, M.D.Search for more papers by this author, Donald B. Louria, M.D., F.A.C.P.Search for more papers by this author, Anne Blevins, R.N.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-68-5-1173_2 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptNinety-six different salmonella isolations from 92 patients occurring over an 11-year period at Memorial Center were reviewed;Salmonella typhimuriumandSalmonella derbyinfections made up almost two thirds of the isolations with almost all of the latter serotype appearing during theS. derbyepidemic of 1963 to 1964. Practically all the patients had serious underlying disease, and in addition most were under or had undergone recent adrenocorticosteroid treatment, chemotherapy, or radiation therapy. The predisposition of patients with recent surgery to salmonellosis, especially after gastrointestinal procedures, was reaffirmed. The overall distribution of the type of clinical syndrome was unusual; 30.2% had... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: New York, New York PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited bySalmonellosis complicating neoplastic diseases 1 May 1968Volume 68, Issue 5Page: 1173-1174KeywordsChemotherapyRadiation therapySalmonellaSalmonellosisSurgeryTyphoid Issue Published: 1 May 1968 PDF downloadLoading ...
Interferon-alpha affects the immune response in post-transplant lymphoproliferative disorder.
Authors: A Faro, G Kurland, M G Michaels, P S Dickman, P G Greally, K J Spichty, B B Noyes, S R Boas, F J Fricker, J M Armitage, A Zeevi
Journal: American Journal of Respiratory and Critical Care Medicine (1996)

Post-transplant lymphoproliferative disorder (PTLD) is associated with Epstein-Barr virus (EBV) and characterized by fever, lymphadenopathy, and graft dysfunction. We describe the clinical course of an EBV seronegative 11-yr-old boy who underwent double lung transplantation and subsequently developed PTLD in the graft. A reduction in immunosuppression and the addition of acyclovir did not result in improvement. Treatment with interferon-alpha (IFN-alpha), however, led to dramatic clinical, radiographic, and histologic improvement. Semiquantitative measurements of cytokine mRNA in his bronchoalveolar lavage cells prior to therapy with IFN-alpha revealed high levels of IL-4 and IL-10 mRNA, which decreased significantly with treatment. We speculate that the beneficial effect of IFN-alpha in the treatment of PTLD is directly related to the inhibition of type 2 helper (Th2-like) T-cells.
Variable phenotype of familial adenomatous polyposis in pedigrees with 3′ mutation in the APC gene
Authors: J D Brensinger, S J Laken, M C Luce, S M Powell, G H Vance, D J Ahnen, G M Petersen, S R Hamilton, F M Giardiello
Journal: Gut (1998)

Background —Germline mutation in the adenomatous polyposis coli (APC) gene on chromosome 5 causes familial adenomatous polyposis. “Attenuated” phenotype has been reported with mutation in the 5′ end of the gene (5′ to codon 158), but genotype-phenotype relations at the 3′ end (3′ to codon 1596) have not been described fully. Aims —To describe and compare colorectal and extracolonic phenotypes in a case series of families with mutation in the 3′ end of the APC gene. Methods —Thirty one at risk or affected members from four families with a mutation in the APC gene located at codon 1979 or 2644 were evaluated. Results —Variable intrapedigree colorectal phenotype was observed: some members at older age had oligopolyposis (fewer than one hundred colorectal adenomas) whereas other members had classic polyposis at young age. Colorectal cancer was diagnosed at older mean age (50 (7) years) in the four families than in classic FAP pedigrees (39 (14) years). Extracolonic lesions characteristic of FAP occurred with 3′ APC mutations, but variability in intrapedigree and interpedigree extracolonic phenotype and dissociation of severity of extracolonic manifestations from number of colorectal polyps was noted. Conclusions —Families with 3′ mutations of the APC gene exhibit variable intrapedigree phenotype similar to the heterogeneity noted in families with proximal 5′ mutations. Genotyping of FAP and oligopolyposis pedigrees can guide appropriate surveillance of the upper and lower gastrointestinal tract in affected members.
Preferential vasoconstriction to cysteinyl leukotrienes in the human saphenous vein compared with the internal mammary artery. Implications for graft performance.
Authors: S P Allen, A H Chester, M R Dashwood, S Tadjkarimi, P J Piper, M H Yacoub
Journal: Circulation (1994)

BACKGROUND Platelet aggregation with the release of their vasoactive mediators is an important factor contributing to the patency of coronary bypass grafts. However, the role of leukocyte-derived mediators on graft performance is unclear. Leukotrienes (LTs) are proinflammatory mediators released from a variety of leukocytes that possess both vasoactive and mitogenic properties. We have therefore compared the effects of the cysteinyl LTs (C4, D4, and E4) on the human saphenous vein (SV) and human internal mammary artery (IMA). METHODS AND RESULTS Human SVs from 43 patients (mean age, 58 years) and IMAs from 33 patients (mean age, 57 years) were obtained from individuals undergoing coronary artery bypass surgery for coronary artery disease. The samples were set up in organ baths to record changes in vessel wall tension. In undistended SVs the cysteinyl LTs elicited concentration-dependent contractions. The Emax for LTE4 (4.23 +/- 1.0 mN; n = 6) was significantly less than that observed with either LTC4 (25.7 +/- 4.01 mN; n = 7; P &lt; .001) or LTD4 (26.19 +/- 3.16 mN; n = 7; P &lt; .001). In addition, the LTD4 receptor antagonist ICI 198615 (30 nmol/L) significantly inhibited the LTD4 concentration-response curve but not the LTC4 responses. Furthermore, treatment of the SV with acivicin (0.05 mmol/L), a gamma-glutamyl transpeptidase inhibitor, caused a significant rightward displacement of the LTC4 concentration-response curve. In contrast, LTC4 and LTD4 produced a response in IMAs from only 3 of 29 patients. LTC4 and LTD4 produced small contractions, of which the maximum responses were 3.28 +/- 1.92 mN (n = 5) and 3.12 +/- 1.38 mN (n = 5). LTE4 produced no responses in the IMA. Experiments in which the SV was pretreated with L-NG-monomethyl-L-arginine (L-NMMA; 10(-4) mol/L) or indomethacin (10(-5) mol/L) or was denuded of endothelium had no significant effect on the Emax values for LTE4. Also, the IMA remained unresponsive to cysteinyl leukotrienes after treatment with L-NMMA or indomethacin or endothelium removal. In vitro autoradiography localized specific [3H]-LTC4 and [3H]-LTD4 binding sites (putative receptors) to the smooth muscle cells of both SV and IMA, with greater binding to the SV. CONCLUSIONS Our data show that there is a preferential contraction to LTs in SV compared with IMA. This difference in smooth muscle cell reactivity to the cysteinyl LTs suggests that endogenous LT production from circulating or infiltrating leukocytes may be an important factor contributing to graft function.
COMPARISON OF VASCULAR RESPONSE TO NOVOLIMUS-ELUTING STENT VERSUS ZOTAROLIMUS-ELUTING STENT IMPLANTATION: IVUS RESULTS FROM THE EXCELLA BD TRIAL
Authors: Hideki Kitahara, Katsuhisa Waseda, Ryotaro Yamada, Joo-Yong Hahn, Kenji Sakamoto, Paul Yock, Joachim Schofer, Karl E. Hauptmann, Christophe Dubois, Alexandre Abizaid, stefan verheye, Yasuhiro Honda, Peter Fitzgerald
Journal: Journal of the American College of Cardiology (2012)
Differentiation therapy of hepatocellular carcinoma in mice with recombinant adenovirus carrying hepatocyte nuclear factor-4α gene
Authors: Chuan Yin, Yong Lin, Xin Zhang, Yue-Xiang Chen, Xin Zeng, Hai-Yan Yue, Jun-Liang Hou, Xing Deng, Jun-Ping Zhang, Ze-Guang Han, Wei-Fen Xie
Journal: Hepatology (2008)

Abstract Previous studies have shown that hepatocyte nuclear factor-4α (HNF4α) is a central regulator of differentiated hepatocyte phenotype and forced expression of HNF4α could promote reversion of tumors toward a less invasive phenotype. However, the effect of HNF4α on cancer stem cells (CSCs) and the treatment of hepatocellular carcinoma (HCC) with HNF4α have not been reported. In this study, an adenovirus-mediated gene delivery system, which could efficiently transfer and express HNF4α, was generated to determine its effect on hepatoma cells (Hep3B and HepG2) in vitro and investigate the anti-tumor effect of HNF4α in mice. Our results demonstrated that forced re-expression of HNF4α induced the differentiation of hepatoma cells into hepatocytes, dramatically decreased “stemness” gene expression and the percentage of CD133+ and CD90+ cells, which are considered as cancer stem cells in HCC. Meanwhile, HNF4α reduced cell viability through inducing apparent apoptosis in Hep3B, while it induced cell cycle arrest and cellular senescence in HepG2. Moreover, infection of hepatoma cells by HNF4α abolished their tumorigenesis in mice. Most interestingly, systemic administration of adenovirus carrying the HNF4α gene protected mice from liver metastatic tumor formation, and intratumoral injection of HNF4α also displayed significant antitumor effects on transplanted tumor models. Conclusion: The striking suppression effect of HNF4α on tumorigenesis and tumor development is attained by inducing the differentiation of hepatoma cells—especially CSCs—into mature hepatocytes, suggesting that differentiation therapy with HNF4α may be an effective treatment for HCC patients. Our study also implies that differentiation therapy may present as one of the best strategies for cancer treatment through the induction of cell differentiation by key transcription factors. (Hepatology 2008.)
Emerging invasive liver abscess caused by K1 serotype Klebsiella pneumoniae in Korea
Authors: D.R. Chung, S.S. Lee, H.R. Lee, H.B. Kim, H.J. Choi, J.S. Eom, J.S. Kim, Y.H. Choi, J.S. Lee, M.H. Chung, Y.S. Kim, H. Lee, M.S. Lee, C.K. Park
Journal: Journal of Infection (2006)
[489] SERUM HEPATITIS B SURFACE ANTIGEN (HBsAg) LEVEL CAN REFLECT HEPATITIS B VIRUS IN THE LIVER AND PREDICT TREATMENT RESPONSE
Authors: H.L.Y. Chan, V.W.S. Wong, A.M.L. Tse, C.H. Tse, A.M.L. Chim, H.Y. Chan, G.L.H. Wong, J.J.Y. Sung
Journal: Journal of Hepatology (2007)
Antioxidant Vitamin C Improves Endothelial Dysfunction in Chronic Smokers
Authors: Thomas Heitzer, Hanjo¨rg Just, Thomas Mu¨nzel
Journal: Circulation (1996)

Background Chronic smoking is associated with endothelial dysfunction, an early stage of atherosclerosis. It has been suggested that endothelial dysfunction may be a consequence of enhanced degradation of nitric oxide secondary to formation of oxygen-derived free radicals. To test this hypothesis, we investigated the effects of the antioxidant vitamin C on endothelium-dependent responses in chronic smokers. Methods and Results Forearm blood flow responses to the endothelium-dependent vasodilator acetylcholine (7.5, 15, 30, and 60 μg/min) and the endothelium-independent vasodilator sodium nitroprusside (1, 3, and 10 μg/min) were measured by venous occlusion plethysmography in 10 control subjects and 10 chronic smokers. Drugs were infused into the brachial artery, and forearm blood flow was measured for each drug before and during concomitant intra-arterial infusion of the antioxidant vitamin C (18 mg/min). In control subjects, vitamin C had no effect on forearm blood flow in response to acetylcholine and sodium nitroprusside. In contrast, in chronic smokers the attenuated forearm blood flow responses to acetylcholine were markedly improved by concomitant administration of vitamin C, whereas the vasodilator responses to sodium nitroprusside were not affected. Conclusions The present studies demonstrate that the antioxidant vitamin C markedly improves endothelium-dependent responses in chronic smokers. This observation supports the concept that endothelial dysfunction in chronic smokers is at least in part mediated by enhanced formation of oxygen-derived free radicals.
The cellular origin and malignant transformation of Waldenström macroglobulinemia
Authors: Bruno Paiva, Luis A. Corchete, Maria-Belen Vidriales, Ramón García-Sanz, Jose J. Perez, Irene Aires-Mejia, Maria-Luz Sanchez, Paloma Barcena, Diego Alignani, Cristina Jimenez, Maria-Eugenia Sarasquete, María-Victoria Mateos, Enrique M. Ocio, Noemi Puig, Fernando Escalante, José Hernández, Rebeca Cuello, Alfonso García de Coca, Magdalena Sierra, Maria-Carmen Montes, Tomás J. González-López, Josefina Galende, Abelardo Bárez, José Alonso, Emilia Pardal, Alberto Orfao, Norma C. Gutierrez, Jesús F. San Miguel
Journal: Blood (2015)
How does implicit and explicit knowledge fit in the consciousness of action?
Authors: Nicolas Georgieff, Yves Rossetti
Journal: Behavioral and Brain Sciences (1999)

Dienes &amp; Perner's (D&amp;P's) target articles proposes an analysis of explicit knowledge based on a progressive transformation of implicit into explicit products, applying this gradient to different aspects of knowledge that can be represented. The goal is to integrate a philosophical concept of knowledge with relevant psychophysical and neuropsychological data. D&amp;P seem to fill an impressive portion of the gap between these two areas. We focus on two examples where a full synthesis of theoretical and empirical data seems difficult to establish and would require further refinement of the model: action representation and the closely related consciousness of action, which is in turn related to self-consciousness.
Nasal Packing After Surgery-Reply
Authors: I. M. Baird, J. C. Trabue
Journal: JAMA (1982)

In Reply.—  Although we agree with Dr Fernbach that nasal packing has its disadvantages, the short-term use of packing to effect hemostasis is widely used. The patient described in our report had severe nasal deformity that necessitated septal reconstruction, and we believed that nasal packing was required. We disagree with Herzon's conclusions, 1 since we believe that the isolation of bacteria from the nasal cavity is not synonymous with the presence of infection.  The use of antibiotic-impregnated gauze as a form of antibiotic prophylactic may serve the purpose of diminishing the fetid odor of nasal packing that has been in situ for 48 hours but will not affect the development of invasive infection. The use of prophylactic antibiotics in any form can be justified only if there is a substantial risk of infection and if the use of such antibiotics is known to be of value. 2 We believe that
Single-Agent Versus Combination Chemotherapy in Patients with Advanced Non-small Cell Lung Cancer and a Performance Status of 2: Prognostic Factors and Treatment Selection Based on Two Large Randomized Clinical Trials
Authors: Rogerio Lilenbaum, Victoria M. Villaflor, Corey Langer, Kenneth O'Byrne, Mary O'Brien, Helen J. Ross, Mark Socinski, Fred B. Oldham, Larissa Sandilac, Jack W. Singer, Philip Bonomi
Journal: Journal of Thoracic Oncology (2009)
Mixed connective tissue disease presenting as a left sided pleural effusion.
Authors: Y Ilan, A Ben-Yehuda, E Okon, R Breuer
Journal: Annals of the Rheumatic Diseases (1992)

Mixed connective tissue disease (MCTD) usually occurs in women aged 13-50 years. Pleural effusion is rarely the presenting feature of this disease. The case is reported here of a male patient with MCTD who presented at the age of 79 years with a left sided pleural effusion.
The Value of High-Quality Full-Day Preschool
Authors: Lawrence J. Schweinhart
Journal: JAMA (2014)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Science and the safe period; a compendium of human reproduction.
Authors: Edward T. Tyler
Journal: JAMA (1963)

If one were to wonder about the age limit beyond which even a tremendous scientific intellect can no longer be productive, the answer would not be provided by referring to Carl Hartman. Already in his 83rd year, Dr. Hartman still "keeps rolling along," adding valuable contributions to our scientific information and our understanding of this knowledge. The recognized "dean" of reproduction physiologists, Emeritus Professor of Zoology at the University of Illinois, and Research Director Emeritus of the Ortho Research Foundation has, in his latest volume, produced a text that is excellent in content, style, and interpretation. Its 293 pages are filled with information so succinctly and concisely given, that it might ordinarily require a text much more sizeable to accomplish the same purpose. The only real fault this reviewer finds with the book is its title, as<i>Science and the Safe Period</i>may imply a much more restricted scope than