tbuckley/cabot-search huggingface dataset:
The occurrence of two types of amyloid in the same patient
Authors: S. Koba, T. Inoue, M. Otu, Y. Miura, N. Misago, Y. Narisawa
Journal: British Journal of Dermatology (2008)

Journal Article The occurrence of two types of amyloid in the same patient Get access S. Koba, S. Koba Faculty of Medicine, Saga University, Division of Dermatology, Department of Internal Medicine, Saga University Faculty of Medicine, 5‐1‐1 Nabeshima, Saga 849‐8501, Japan E‐mail: kobashi@cc.saga‐u.ac.jp Search for other works by this author on: Oxford Academic Google Scholar T. Inoue, T. Inoue Faculty of Medicine, Saga University, Division of Dermatology, Department of Internal Medicine, Saga University Faculty of Medicine, 5‐1‐1 Nabeshima, Saga 849‐8501, Japan E‐mail: kobashi@cc.saga‐u.ac.jp Search for other works by this author on: Oxford Academic Google Scholar M. Otu, M. Otu Faculty of Medicine, Saga University, Division of Dermatology, Department of Internal Medicine, Saga University Faculty of Medicine, 5‐1‐1 Nabeshima, Saga 849‐8501, Japan E‐mail: kobashi@cc.saga‐u.ac.jp Search for other works by this author on: Oxford Academic Google Scholar Y. Miura, Y. Miura Faculty of Medicine, Saga University, Division of Dermatology, Department of Internal Medicine, Saga University Faculty of Medicine, 5‐1‐1 Nabeshima, Saga 849‐8501, Japan E‐mail: kobashi@cc.saga‐u.ac.jp Search for other works by this author on: Oxford Academic Google Scholar N. Misago, N. Misago Faculty of Medicine, Saga University, Division of Dermatology, Department of Internal Medicine, Saga University Faculty of Medicine, 5‐1‐1 Nabeshima, Saga 849‐8501, Japan E‐mail: kobashi@cc.saga‐u.ac.jp Search for other works by this author on: Oxford Academic Google Scholar Y. Narisawa Y. Narisawa Faculty of Medicine, Saga University, Division of Dermatology, Department of Internal Medicine, Saga University Faculty of Medicine, 5‐1‐1 Nabeshima, Saga 849‐8501, Japan E‐mail: kobashi@cc.saga‐u.ac.jp Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 158, Issue 4, 1 April 2008, Pages 860–862, https://doi.org/10.1111/j.1365-2133.2007.08432.x Published: 01 April 2008
The Problem of Sex Today
Authors: NATALIE SHAINESS
Journal: American Journal of Psychiatry (1968)

Sexual problems, especially problems of sexual inadequacy, persist in spite of the current presumed sexual freedom. The author relates this to certain unfortunate aspects of our culture and particularly to increasing alienation and mechanization. She offers a critique of the Masters-Johnson sexual studies, feeling that these researchers have overextended the physiologic aspects of sexual response to cover the entire realm of sexuality. She concludes: We must reaffirm the fundamental connection between human relatedness and physiological sex.
The relationship between mutagenicity and chemical composition of polycyclic aromatic compounds from coal pyrolysis.
Authors: M J Wornat, A G Braun, A Hawiger, J P Longwell, A F Sarofim
Journal: Environmental Health Perspectives (1990)

The polycyclic aromatic compounds (PAC) produced from the pyrolysis of a bituminous coal at temperatures of 1125 to 1425 degrees K prove to be mutagenic to S. typhimurium, both in the presence and in the absence of postmitochondrial supernatant (PMS) prepared from Aroclor 1254-induced rat liver. Mutagenicity of the PAC samples measured in the absence of PMS exhibits little dependence on pyrolysis temperature; that measured in its presence is higher at the higher pyrolysis temperatures. However, because of the decrease in PAC yield as the temperature is raised, mutagenicity per mass of coal consumed falls with an increase in temperature if measured without PMS (-PMS) and peaks at an intermediate temperature of 1378 degrees K if measured with PMS (+PMS). Using a new chromatographic technique, we have split each coal-derived PAC sample into two fractions: LC1, containing PAC with alkyl and O-containing substitutions and LC2, consisting of unsubstituted PAC. Substituted (LC1) fractions show no significant +PMS mutagenicity, indicating that, as a whole, the alkylated PAC in our coal pyrolysis products are not mutagenic. Only at the higher temperatures do the substituted fractions exhibit significant -PMS mutagenicity, attributed to PAC with carbonyl or etheric functionalities. The extremely low yields of the substituted PAC under the conditions where they show some activity, however, ensure that they contribute little to overall mutagenicity. In contrast to the substituted fractions, the unsubstituted (LC2) fractions display significant mutagenicity under all conditions and appear to be responsible for virtually all of the mutagenicity in these coal-derived PAC samples. In this fraction, -PMS activity is attributed to nitrogen-containing heterocyclic aromatics.
PROGNOSTIC VALUE OF CORONARY CTA VERSUS EXERCISE TREADMILL TESTING
Authors: Michael Cheezum, Prem Srinivas Subramaniyam, Marcio Bittencourt, Edward Hulten, Brian Ghoshhajra, Nishant Shah, Daniel Forman, Jon Hainer, Marcia Leavitt, Ram Padmanabhan, Hicham Skali, Sharmila Dorbala, Udo Hoffmann, Suhny Abbara, Henry Gewirtz, Marcelo Di Carli, Ron Blankstein
Journal: Journal of the American College of Cardiology (2014)
Labeled Leukocyte Imaging in Chemical Cystitis
Authors: CHRISTOPHER J. PALESTRO, I RANDELL COHEN, STANLEY J. GOLDSMITH
Journal: Clinical Nuclear Medicine (1993)

A 72-year-old woman, who had been treated with intravesical instillation of formalin for hemorrhagic cystitis (secondary to cyclophosphamide therapy), underwent ln-111-labeled leukocyte scintigraphy for a suspected intra-abdominal abscess. Although no focus of infection was identified, intense bladder wall uptake of labeled leukocytes, presumably the result of chemical cystitis, was observed.
Diagnosis in the Public Domain
Authors: Jerome P. Kassirer
Journal: New England Journal of Medicine (1993)

Many people gasped several weeks ago when Boston Celtics captain Reggie Lewis slumped to the parquet floor during a playoff game at Boston Garden. In part, their memory of Hank Gathers, the college basketball star who only three years earlier collapsed and died during a game in Los Angeles, was simply too striking to ignore. A few days after Lewis' fall, there was another gasp when doctors at different Boston hospitals not only made different diagnoses but also bickered in the popular media about how to interpret Lewis' diagnostic tests. Newspaper and magazine reporters scrambled to unscramble the puzzle, but . . .
The Long Slow Arc Between Things
Authors: M. Kaufmann
Journal: JAMA (1982)

1 The way a mind can be eaten and starved. My father, uncharacteristically believing the lies of his doctors, unable to read their faces or spell "world" backward, his task for today. Unable to add or subtract in his head. Someone in the corridor telling me we are all dying. 2 Standing in the doorway, I coach him in his lessons. One or two right answers and the doctors will relent. Such simple questions. I mouth it over and over, "d-l-r-o-w," 12 from 34 equals 22, 12 plus 34 is 46. Forty-six. I say it for myself. In the hallway I am ashamed. My face is hot with it. Becoming a parent now, the voice in the next room is mine, apologizing to his new teachers, keeping bad news from a sleeping child. What waits in our blood bringing on these failures. If actuary's charts are accurate then we're disappointing
Response to Comment on Pepino et al. Sucralose Affects Glycemic and Hormonal Responses to an Oral Glucose Load. Diabetes Care 2013;36:2530–2535
Authors: M. Yanina Pepino, Samuel Klein
Journal: Diabetes Care (2014)

We appreciate the insightful comments by Grotz and Jokinen (1) regarding our study (2) that found that ingesting sucralose affects the metabolic response to subsequent glucose ingestion.

Grotz and Jokinen imply that the greater increase in peak plasma glucose concentration during the oral glucose tolerance test (OGTT) after sucralose than water ingestion was not clinically important because the concentrations were still within the normal range for an OGTT. However, sucralose ingestion also caused a 20% increase in total plasma insulin concentrations, which demonstrates insulin resistance, which is a known risk factor for diabetes, metabolic syndrome, and cardiovascular disease (3). The clinical relevance of this observation is not …
Microbial communities in the respiratory tract of patients with interstitial lung disease
Authors: Christian Garzoni, Silvio D Brugger, Weihong Qi, Sarah Wasmer, Alexia Cusini, Philippe Dumont, Meri Gorgievski-Hrisoho, Kathrin Mühlemann, Christophe von Garnier, Markus Hilty
Journal: Thorax (2013)

<h3>Background</h3> Molecular methods based on phylogenetic differences in the 16S rRNA gene are able to characterise the microbiota of the respiratory tract in health and disease. <h3>Objectives</h3> Our goals were (1) to characterise bacterial communities in lower and upper airways of patients with interstitial lung disease (ILD) and (2) to compare the results with the microbiota of patients with <i>Pneumocystis</i> pneumonia (PCP) and normal controls. <h3>Methods</h3> We examined the upper and lower respiratory tract of 18 patients with ILD of whom 5, 6, and 7 had idiopathic interstitial pneumonia (IIP), non-IIP and sarcoidosis, respectively. In addition, six immune-compromised patients with PCP and nine healthy subjects were included as controls. Exclusion criteria were recent bacterial/viral respiratory tract infection, HIV-positivity and subjects receiving antibiotic therapy. Bronchoalveolar lavage fluid and oropharyngeal swabs were simultaneously collected, and microbiota was characterised by ultra-deep 16S rRNA gene sequencing. <h3>Results</h3> The microbiota in lower airways of the majority of patients (30; 90%) primarily consisted of Prevotellaceae, Streptococcaceae and Acidaminococcaceae. α and β diversity measurements revealed no significant differences in airway microbiota composition between the five different groups of patients. Comparison of bacterial populations in upper and lower respiratory tract showed significant topographical discontinuities for 7 (23%) individuals. <h3>Conclusions</h3> IIP, non-IIP and sarcoidosis are not associated with disordered airway microbiota and a pathogenic role of commensals in the disease process is therefore unlikely. Nevertheless, molecular analysis of the topographical microbiota continuity along the respiratory tract may provide additional information to assist management of individual patients.
"The First Fifteen Medical Colleges in the United States"
Authors: Charles W. Allen
Journal: JAMA (1913)

Indigent Consumptives in the Southwest\p=m-\AWarning To the Editor:\p=m-\Iwish that publicity be given to the fact that this community, which is famed as a health-resort in the dry zone of the Southwest, will not give financial assistance \p=m-\freehospitals or sanatorium service or transportation\p=m-\to the hundreds of indigent tuberculous persons who apply for aid each year.So many incurable patients arrive here with- out means of support, and yet with hope of climatic cure and remunerative employment, that I desire these full explanations be made:1.Such rainbow-chasing is a cruel hoax to perpetrate on a dying consumptive.2. Comfort and treatment are expensive and continuous.3. It is the rare exception, and growing rarer, that a tuber- culous person can obtain employment, no matter how great his ability.
Aortic Valvular Surgery with Artificial Valves
Authors: EARLE B. KAY, HENRY A. ZIMMERMAN, DAVID MENDELSOHN
Journal: Circulation (1963)

An attempt has been made to present a profile of patients with aortic valvular disease who presented themselves for operative correction, and to demonstrate the effectiveness of prosthetic replacement in the surgical treatment. Experience to date, in 115 patients so treated, demonstrates the effectiveness of this technique. The operative mortality due to technical factors has been low, and the clinical results have been excellent. Since the operative mortality now occurs primarily in those patients with myocardial failure, its prevention, if possible, is advisable by earlier detection and surgical correction.
Correction: Neomycin Absorption
Authors: KERRY J. BREEN
Journal: Annals of Internal Medicine (1972)

Letters, Comments, and Corrections1 May 1972Correction: Neomycin AbsorptionKERRY J. BREEN, M.B., STEVEN SCHENKER, M.D.KERRY J. BREEN, M.B.Search for more papers by this author, STEVEN SCHENKER, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-76-5-837_3 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: In our paper, "Neomycin Absorption in Man" (Ann Intern Med76:211-218, 1972), which appeared in the February issue, the sentence on page 211, "In normal subjects absorption of a single oral dose of neomycin has been measured at between 6% and 3%," should read "at between 0.6% and 3%."... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: KERRY J. BREEN, M.B.; STEVEN SCHENKER, M.D.Affiliations: Department of Medicine School of Medicine Vanderbilt University Nashville, Tenn. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 May 1972Volume 76, Issue 5Page: 837-837KeywordsNeomycins ePublished: 1 December 2008 Issue Published: 1 May 1972 PDF downloadLoading ...
Do Conventional Cleaning and Disinfection Techniques Avoid the Risk of Endoscopic<i>Helicobacter pylori</i>Transmission?
Authors: M. Nürnberg, H. J. Schulz, H. Rüden, K. Vogt
Journal: Endoscopy (2003)

The aim of the present study was to determine whether endoscopes serve as a reservoir for Helicobacter pylori and whether the disinfection technique currently recommended for manual cleaning and disinfection of the instruments completely removes the risk of H. pylori transmission.A prospective study was carried out in 400 patients who were undergoing upper gastrointestinal endoscopy for routine clinical indications. The patients' H. pylori status of the patients was identified using a urea detection system (HUT) and culture. H. pylori contamination was assayed by culturing rinsing samples from the endoscopes before and after manual cleaning and disinfection. Gastric biopsies were assayed using rapid urease testing (Helicobacter urease test, HUT) of two antral and gastric body biopsies and cultures.A total of 128 of the 400 patients examined were found to be H. pylori-positive using HUT testing. Endoscopes were contaminated in 54 of the 128 rinsing samples from endoscopes used in H. pylori-positive patients (42 %) before cleaning and disinfection. One of the 128 rinsing samples (0.8 %) was found to be contaminated with H. pylori even after routine manual cleaning and disinfection - indicating that these cleaning and disinfection procedures may be insufficient to eradicate H. pylori from endoscopes completely. No seroconversion was observed during serological follow-up in the patient who had previously been examined with an endoscope contaminated with H. pylori. The patient was still found to be seronegative 5 months after inoculation.Endoscopes are frequently contaminated with H. pylori immediately after gastroduodenal endoscopy in H. pylori-infected patients. Iatrogenic transmission is possible, as H. pylori can survive manual cleaning and disinfection with 2 % glutaraldehyde, particularly when there is ineffective cleaning before disinfection.
Stimulus-specific deactivation of chemotactic factor-induced cyclic AMP response and superoxide generation by human neutrophils.
Authors: L Simchowitz, J P Atkinson, I Spilberg
Journal: Journal of Clinical Investigation (1980)

The responses of isolated human peripheral neutrophils to either simultaneous or sequential additions of two chemotactic factors were studied. Simultaneous additions of formyl-methionyl-leucyl-phenylalanine (10-100 nM) and the fifth component of complement, C5a (1-10 microliters/ml), evoked partially additive responses of membrane depolarization as measured by the fluorescent dye 3,3'-dipropyl-thiocarbocyanine, a transient elevation of intracellular cyclic AMP (cAMP), and superoxide (O2-) generation as assessed by ferricytochrome c reduction. Preincubation of the cells with either formyl-methionyl-leucyl-phenylalanine or C5a alone caused dose-dependent inhibition of the depolarization, the cAMP increase, and O2- release induced by a subsequent exposure to an optimal dose of the same stimulus, i.e., deactivation occurred. In contrast, when cells were treated with one chemotactic factor and then exposed to the other stimulus, the cells exhibited a normal response of peak depolarization, the rise in cAMP, and O2-0 production i.e., cross-deactivation failed to occur. The results imply that deactivation of these phenomena is stimulus specific. Further, these observations are consistent with the hypothesis that cross-deactivation of chemotaxis is mediated by one or more processes that are irrelevant to O2- generation, and that occur distal to the depolarization and cAMP steps in the sequence of neutrophil activation: possibly microtubule polymerization and orientation.
Histologic Markers of Inflammation in Patients With Ulcerative Colitis in Clinical Remission
Authors: Laura Rosenberg, Kavinderjit S. Nanda, Talia Zenlea, Anne Gifford, Garrett O. Lawlor, Kenneth R. Falchuk, Jacqueline L. Wolf, Adam S. Cheifetz, Jeffrey D. Goldsmith, Alan C. Moss
Journal: Clinical Gastroenterology and Hepatology (2013)
Cataract Surgery — A Modern Attitude toward a Technologic Explosion
Authors: Norman S. Jaffe
Journal: New England Journal of Medicine (1978)

DURING the past 40 years a much more liberal approach to the indications for cataract surgery has developed. This tendency has been especially apparent in the United States, where the number of cataract operations performed per capita population considerably exceeds that of any other country in the Western World. This development has resulted in some criticism from those who maintain that this more liberal interpretation is not medically, socially and economically justified. The controversy has placed ophthalmology in the "eye" of a surgical storm.1 An examination of the changing scene of cataract surgery will help provide some answers to the . . .
Effectiveness of occlusive bedding in the treatment of atopic dermatitis – a placebo‐controlled trial of 12 months' duration
Authors: L. Holm, S. Öhman, Å. Bengtsson, M. Van Hage‐Hamsten, A. Scheynius
Journal: Allergy (2001)

Background: Several studies on avoidance of house‐dust‐mite (HDM) and cat allergens have been carried out, most of them in asthmatic patients and only a few in patients with atopic dermatitis (AD). No study so far has focused on which subgroup of AD patients benefits from avoidance measures. Methods: Forty adult patients with AD completed the 12‐month avoidance study. They were divided into an active treatment ( n =22) and a placebo ( n =18) group. Active treatment comprised use of polyurethane‐coated cotton encasings for bedding, and placebo use of cotton covers. Patients came for regular checkups during the 12‐month period, when eczema severity was assessed and blood samples were analyzed for total IgE, HDM‐ and cat‐specific IgE and soluble CD30 (sCD30) in serum. Dust samples were collected from mattresses before treatment and after 3, 6, and 12 months, and analyzed for content of HDM and cat allergen. Results: Eczema severity decreased significantly in both groups ( P &lt;0.001), with a more pronounced decrease in patients with active covers. The HDM exposure decreased significantly in the active treatment group ( P &lt;0.001), and the levels of HDM‐specific IgE were reduced ( P &lt;0.05). Exposure to cat allergens was unchanged in the active treatment group but decreased, albeit not significantly ( P =0.19), in the placebo group. sCD30 levels were significantly reduced in both groups ( P &lt;0.001). Patients not sensitized to HDM allergens benefited from the bedcovers as much as sensitized patients. Conclusions: Occlusive bedding significantly reduced HDM exposure in bed ( P &lt;0.001) and eczema severity, and sCD30 levels decreased significantly ( P &lt;0.001). Patients not sensitized to HDM and not exposed to HDM allergens benefited equally from use of the bedcovers, a result which could be due to a reduction of other important allergens, superantigens, or irritants in bed. We therefore recommend the use of bedcovers as part of treatment for AD.
Reciprocal association of plasma IGF-1 and interleukin-6 levels with cardiometabolic risk factors in nondiabetic subjects. Diabetes Care 2008;31:1886–1888
Authors: E Succurro, F Andreozzi, A Sciacqua, ML Hribal, F Perticone, G Sesti
Journal: Diabetes Care (2012)

Succurro E, Andreozzi F, Sciacqua A, Hribal ML, Perticone F, Sesti G. Reciprocal association of plasma …
The Case for Animal Experimentation: An Evolutionary and Ethical Perspective
Authors: Michael T. McGuire
Journal: JAMA (1986)

<h3>Alternatives to Animal Use in Research, Testing, and Education, by the Office of Technology Assessment, 441 pp, with illus, $16, Washington, DC, Office of Technology Assessment, 1986.</h3> In considering books on animal rights, it is wise to remember several things. First, if there were no evidence that using animals for research, testing, and educational purposes was helpful, current practices of animal use would soon disappear. Second, if, for example, we could be assured of curing cancer by sacrificing another 100 laboratory rats, those who lead the battle against the use of animals in laboratories would search in vain for followers. Third, we all agree to, and contribute to, inflicting death and pain on animals, eg, centipedes, disease-carrying mosquitos, rabid dogs, and rats in our pantries. And fourth, if the purposes or certain forms of education could be served by technological devices rather than animals, current practices (eg, surgical training using
Reply to Dr. Gravante et al.
Authors: G. Bresci
Journal: Endoscopy (2006)

The letter from Dr. Gravante and colleagues includes a good retrospective analysis of the incidence of gastrointestinal pathology in patients on the waiting list for liver transplantation. As forecasted, the most common abnormalities were found to be esophageal varices and hypertensive gastropathy, while colonic lesions were found to be less common, and the analysis did not show any significant correlation among the clinical variables. I also agree with the conclusion that colonoscopy should only be performed as indicated by the guidelines for colorectal cancer screening.
Academic Medical Centers and Conflicts of Interest
Authors: Howard Brody
Journal: JAMA (2006)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal