Increased Endothelin Level after Cyclosporine Therapy
Authors: G. Deray, A. Carayon, P. Le Hoang
Journal: Annals of Internal Medicine (1991)

Letters1 May 1991Increased Endothelin Level after Cyclosporine TherapyG. Deray, MD, A. Carayon, MD, P. Le Hoang, MDG. Deray, MD, A. Carayon, MD, P. Le Hoang, MDAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-114-9-809_1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the Editors: The mechanism by which cyclosporine induces acute renal vasoconstriction remains unclear. Endothelin is a novel endothelium-derived vasoconstrictor peptide with a potent and sustained effect (1). Cyclosporine drastically increases the level of endothelin in vivo (in the rat) (2) and in vitro (2, 3). Moreover, the renal constrictive effect of cyclosporine is blunted by endothelin antibody both in isolated rat kidney (4) and in vivo in the rat. These data suggest that endothelin may be an important mediator of cyclosporine-induced renal vasconstriction.We investigated plasma endothelin concentrations in 14 patients (6 men and 8 women) treated with cyclosporine,...References1. YanagisawaKuriharaKimura MHS. A novel potent vasoconstrictor peptide produced by vascular endothelial cells. Nature. 1988;332:441-5. CrossrefGoogle Scholar2. KonSugiuraInagami VMT. Cyclosporine (cy) causes endothelin-dependent acute renal failure [Abstract]. Kidney Int. 1990;37:486. Google Scholar3. BunchmanBrookshire TC. Cyclosporine stimulated synthesis of endothelin by human endothelial cells in tissue culture [Abstract]. Kidney Int. 1990;37:365. Google Scholar4. DadanPericoRemuzzi JNG. Role of endothelin (EN) in cyclosporine (CsA)-induced acute renal vasoconstriction [Abstract]. Kidney Int. 1990;37:479. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Hôpital Pitié-Salpétrière 75013 Paris, France PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByCardioprotective Effects of Nigella sativa Oil on Cyclosporine A-Induced Cardiotoxicity in RatsCyclosporine A induces vascular fibrosis and heat shock protein expression in ratThe effect of cyclosporin A on the level of big endothelin in patients one year after orthotopic heart transplantationCyclosporine A up-regulates expression of matrix metalloproteinase 2 and vascular endothelial growth factor in rat heartCyclosporine toxicity in renal transplant recipients detected by nailfold capillaroscopy with Na-fluoresceinEndothelin in organ transplantationETA receptor-mediated constrictor responses to endothelin peptides in human blood vessels in vitroCategory III Symptom-Modifying Antirheumatic DrugsCyclosporine-Induced Hypertension After TransplantationHepatic and renal blood flow responses to a clinical dose of intravenous cyclosporine in the pigVasoconstrictor endothelin receptors characterized in human renal artery and vein in vitroDe novo hypertension after liver transplantation.Evidence in support of the spasm of resistance vessel concept of ischemic heart disease: An update in 1993The structure and specificity of endothelin receptors: Their importance in physiology and medicineEffects of endothelin on microcirculation of the pancreasIncreased endothelin excretion in rats with renal failure induced by partial nephrectomy 1 May 1991Volume 114, Issue 9Page: 809-809KeywordsAttentionBlood plasmaKidneysVasoconstriction Issue Published: 1 May 1991 PDF DownloadLoading ...