tbuckley/cabot-search huggingface dataset:
Exacerbation of psoriasis by thalidomide in Behcet's syndrome
Authors: C.M. Dobson, R.A. Parslew
Journal: British Journal of Dermatology (2003)

Sir, We report a 46‐year‐old woman with severe orogenital ulceration as the dominant feature of Behçet's syndrome. This was unresponsive to a variety of topical and systemic agents, including dapsone and colchicine. She also exhibited minor stable chronic plaque psoriasis of the elbows only [Psoriasis Area and Severity Index (PASI) score < 5], which was untreated and had not flared significantly in its 5‐year duration. Due to the severity of her orogenital symptoms, a trial of low‐dose thalidomide (50 mg daily) was commenced. Within 4 days this was stopped by the patient, due to a severe and progressive eruption of her psoriasis. This took the form of small plaque psoriasis (PASI score 15). There was no change in her orogenital symptoms, as expected during this short time. She was started on methotrexate 7·5 mg weekly and her psoriasis became stable again on methotrexate 15 mg weekly after 3 months. This also had no effect on her orogenital symptoms, and she is currently being assessed with a view to ciclosporin treatment of her Behçet's syndrome.
Tc-99m RBC SPECT Demonstrating Vertebral Hemangioma
Authors: YUN-YOUNG CHOI, JIN-YONG SEONG, SEOUNG-OH YANG, SEUNG-RO LEE, SUKSHIN CHO
Journal: Clinical Nuclear Medicine (1998)

Plain radiographs of a 68-year-old man with lower back pain showed degenerative changes in the lumbar spine. An MRI showed a herniated disc at L5-S1 and an unexpected lesion in the L1 body suggesting a possible malignancy. Lumbar SPECT showed slightly decreased uptake in L1. Therefore, a benign condition such as a hemangioma was entertained as a possibility. Tc-99m RBC SPECT showed increased uptake in L1, suggesting the possibility of a vertebral hemangioma. A CT scan of the lumbar spine showed typical findings of hemangioma.
Monoclonal antibody to an IgD allotype induces a new type of allotype suppression in the mouse.
Authors: T Tokuhisa, F T Gadus, L A Herzenberg, L A Herzenberg
Journal: The Journal of Experimental Medicine (1981)

Studies presented here show that perinatal exposure to anti-IgD allotype antibodies induces a persistant IgG-allotype suppression in the mouse that differs markedly from either the short-term or chronic allotype suppressions induced by antibodies to IgG or IgM allotypes. This novel form of allotype suppression induced by injecting neonatal BALB/c x SJL mice with monoclonal antibody to the paternal Igh-5b (IgD) allotype drastically reduces paternal allotype production during the first 6 mo of the affected animal's life and simultaneously stimulates compensatory production of maternal allotype IgG. In addition, it interferes with the development of B cells carrying the paternal IgD allotype and impairs the development of memory B cells destined to give rise to paternal allotype IgG-producing cells. Thus, its properties make it more like allotype suppression as described in the rabbit than like the known forms of allotype suppression in the mouse. As shown here, Igh-5b-bearing (5b+) B cells are completely depleted from the neonate after anti-5b exposure and only gradually appear as the animal ages. The recovery of the 5b+ population to near normal size (by approximately 14 wk of age) substantially preceeds recovery of the ability to generate normal-size memory B cell populations. Paternal allotype levels in serum remain well below normal until the anti-5b-exposed animals reach approximately 6 mo of age and then climb rapidly, finally stabilizing at levels comparable to levels in controls of the same age. The elevated maternal allotype levels characteristic of the suppression period began falling somewhat earlier and are clearly stabilized within the normal range in 6-mo-old animals. Thus, perinatal exposure to anti-5b compromises B cell development and IgG production throughout early adulthood but has little apparent effect in older animals. Perinatal exposure to antibody to the paternal IgG2a allotype (Igh-1b) or IgM allotype (Igh-6b), in contrast, induces a chronic allotype suppression that has relatively little affect on IgG production in young adults but severely suppresses allotype production in older animals. Furthermore, this type of (chronic) suppression does not influence maternal allotype production and does not interfere with memory B cell development. These differences, illustrated here by data from parallel sets of animals exposed either toi anti-5b or anti-1b, raise a series of intriguing questions concerning the mechanisms regulating B cell development and expression and the nature of the neonatal (B) cell populations with which the suppression-inducing antibodies react.
SPONTANEOUS RUPTURE OF THE SPLEEN FOLLOWING A CARBUNCLE
Authors: H. S. DIEHL
Journal: JAMA (1924)

Traumatic rupture of the spleen, as the result of a contusion, a fall or a blow, is not uncommon. Spontaneous rupture is much less frequent, although cases are reported in patients with certain diseases, particularly malaria 1 and typhoid fever. 2 In a few of these cases the rupture seems entirely spontaneous, but in most of them it accompanies some exertion, usually severe, but at times very slight.  Connors 3 reported a case of a man who, except for some constipation extending over a period of three weeks, seemed in good health until he experienced a sudden, sharp pain in the left hypochondrium. Operation showed a rupture of the spleen with a subcapsular hematoma. No history of injury or exertion could be obtained. Connors compiled from the literature twelve cases of spontaneous rupture of the spleen. Five of these were in tropical countries, so, although no diagnosis of malaria is
Modified Desensitization Protocol Using Two Formulations of L-Asparaginase in a Pediatric Patient with Recurrent Acute Lymphoblastic Leukemia (ALL)
Authors: M.H. LeBras, S.L. Saccente, R.L. Saylors, T.T. Perry, S.M. Jones, A.M. Scurlock
Journal: Journal of Allergy and Clinical Immunology (2006)
CaV2.3 Channels Are Critical for Oscillatory Burst Discharges in the Reticular Thalamus and Absence Epilepsy
Authors: Tariq Zaman, Kyoobin Lee, Cheongdahm Park, Afshin Paydar, Jee Hyun Choi, Eunji Cheong, C. Justin Lee, Hee-Sup Shin
Journal: Neuron (2011)
The use of high-hydrostatic pressure treatment to decellularize blood vessels
Authors: Seiichi Funamoto, Kwangwoo Nam, Tsuyoshi Kimura, Ayako Murakoshi, Yoshihide Hashimoto, Kazuo Niwaya, Soichiro Kitamura, Toshiya Fujisato, Akio Kishida
Journal: Biomaterials (2010)
Toxic Effects of Lithium Carbonate in a Mother and Newborn Infant
Authors: George D. Wilbanks
Journal: JAMA (1970)

A patient receiving carefully monitored lithium carbonate therapy in late pregnancy developed a toxic condition during the delivery process, apparently due to hemodynamic or metabolic alterations or both, as no additional lithium carbonate was given. Massive diuresis was effective treatment. The infant also had elevated serum lithium ion levels with the clinical signs of cyanosis and flaccid muscle tone. Both mother and infant have recovered without obvious permanent damage. Extreme caution should be used with lithium carbonate therapy in late pregnancy until further data can be obtained on the maternal-fetal relationship. The promise of effective therapy must be weighed with therapeutic benefit.
ACCIDENTS FOLLOWING THE SUBDURAL INJECTION OF THE ANTIMENINGITIS SERUM
Authors: SIMON FLEXNER
Journal: JAMA (1913)

activity was lost and they had gnawed deep holes into the boards of their pens.By about the end of the fourth week the controls began to appear ill in quite the same way as the vaccinated ones.If will be noted that all guinea-pigs died of general¬ ized miliary tuberculosis and that all had involvement of lungs, liver, spleen, bronchial and meseiiteric lyniph-.les.with lhe exception of one guinea-pig in which the spleen was free and mie in which the liver was free.While one vaccinated guinea-pig lived much longer than any non-vaccinated, 160 days and III days, respectively, yet the average length of life was almost the same, ST.7 days for the vaccinated and 55.2 for the non-vaccinated.CONCLUSIONS from our observations during these experiments, we 'oust, conclude that, immunity was not produced by the vaccine, but it, would seem possible that inasmuch as the vaccinated guinea-pigs became sick first, they were more susceptible at the time of inoculation than the controls.l lake this opportunity to thank Dr. W. Jarvls Barlow n'al the attending stall' of tin: Hai low Sanatorium for their kindly interest and many helpful suggestions during the prog- «"ess of this work.
A CASE OF TUBERCULOSIS OF SPLEEN, WITH SURGICAL TREATMENT.
Authors: A. M. HAYDEN
Journal: JAMA (1898)

A scarcity of literature on the subject of surgery of the spleen has induced me to report the following case, one that has been of unusual interest to me. About Feb. 20, 1896, Mrs. Wm. F., age 24, first felt pain in the left hypochondriac region, which, slight at first, gradually grew more severe until she came under my observation, April 19, 1896. At that time the pain in the region of spleen was at times quite intense, while at others it was entirely absent. There was no rise of temperature, but her pulse was about 100. Her appetite was good, she had no cough or bowel trouble, and attended to her household duties as usual. I prescribed counter irritants externally and quinia and codein internally. Her condition remained about stationary until May 10, when her temperature was 101 degrees and pulse 120. The pain in the spleen was quite severe
Selective portal vein embolization and ligation trigger different regenerative responses in the rat liver
Authors: Katarzyna Furrer, Yinghua Tian, Thomas Pfammatter, Wolfram Jochum, Ashraf Mohammad El-Badry, Rolf Graf, Pierre-Alain Clavien
Journal: Hepatology (2008)

Two strategies are clinically available to induce selective hypertrophy of the liver: portal vein embolization (PVE) and portal vein ligation (PVL). The aim of this study was to compare the impact of PVE and PVL on liver regeneration. Rats were subjected to 70% PVL, 70% PVE, 70% partial hepatectomy (PH) (positive control), or sham operation (negative control). PVL and PVE of liver segments were validated by portography and histology, demonstrating obstruction of the involved portal branches. Liver weight and markers of regeneration were assessed at 24, 48, and 72 hours, and 7 days after surgery (n = 5). Sinusoidal perfusion was examined by intravital microscopy. The weight of the regenerating liver segments increased continuously in all groups, with the highest weight gain after PH, which also disclosed the strongest proliferative activity. In Ki-67 and PCNA stainings, hepatocyte proliferation after PVL was more pronounced than after PVE ( P = 0.01). Volumetric blood flow and functional sinusoidal density were lower after PVE than after PVL ( P = 0.006, P = 0.02, respectively). The accumulation of Kupffer cells 24 hours after the intervention was highest after PH. Transcript levels of cytokines (interleukin-1β, tumor necrosis factor-α, interleukin-6) peaked at 24 hours and were highest after PH. The embolized part of the liver after PVE showed prominent foreign body reaction in the portal triad with accumulation of macrophages. Conclusion: PVL is superior to PVE in inducing a regenerative response of the remnant liver. The impairment of liver regeneration after PVE may be a consequence of macrophage trapping in the occluded segment due to a foreign body reaction. Lower blood flow and lower accumulation of macrophages, particularly Kupffer cells, in the regenerating part of the liver likewise causes impaired liver regeneration after PVE.
Differential splicing of COL4A5 mRNA in kidney and white blood cells: A complex mutation in the COL4A5 gene of an Alport patient deletes the NC1 domain
Authors: Caiying Guo, Boudewijn Van Damme, Rita Van Damme-Lombaerts, Herman Van den Berghe, Jean-Jacques Cassiman, Peter Marynen
Journal: Kidney International (1993)
A 15-µg dose of unadjuvanted influenza A (H1N1) 2009 vaccine was immunogenic in healthy adults within 21 days
Authors: Bruno Granwehr
Journal: Annals of Internal Medicine (2010)

ACP Journal Club19 January 2010A 15-µg dose of unadjuvanted influenza A (H1N1) 2009 vaccine was immunogenic in healthy adults within 21 daysBruno Granwehr, MD, MSBruno Granwehr, MD, MSUniversity of Texas MD Anderson Cancer Center, Houston, Texas, USA (B.G.)Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-152-2-201001190-02009 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail Source CitationGreenberg ME, Lai MH, Hartel GF, et al. Response after one dose of a monovalent influenza A (H1N1) 2009 vaccine—preliminary report. N Engl J Med. 2009;361. https://pubmed.ncbi.nlm.nih.gov/19745216Clinical Impact RatingsGIM/FP/GP: Infectious Disease: Pulmonology: References1 Chan M. World now at the start of 2009 influenza pandemic. www.who.int/mediacentre/news/statements/2009/h1n1_pandemic_phase6_20090611/en/index.html (accessed 24 Nov 2009). Google Scholar2 Rowe T, Abernathy RA, Hu-Primmer J, et al. Detection of antibody to avian influenza A (H5N1) virus in human serum by using a combination of serologic assays. J Clin Microbiol. 1999;37:937-43. [PMID: 10074505] Google Scholar3 Romero Méndez IZ, Shi Y, HogenEsch H, Hem SL. Potentiation of the immune response to non-adsorbed antigens by aluminum-containing adjuvants. Vaccine. 2007;25:825-33. [PMID: 17014935] Google Scholar4 Atmar RL, Keitel WA, Patel SM, et al. Safety and immunogenicity of nonadjuvanted and MF59-adjuvanted influenza A/H9N2 vaccine preparations. Clin Infect Dis. 2006;43:1135-42. [PMID: 17029131] Google Scholar5 Centers for Disease Control and Prevention (CDC). Surveillance for the 2009 pandemic influenza A (H1N1) virus and seasonal influenza viruses—New Zealand, 2009. MMWR Morb Mortal Wkly Rep. 2009;58:918-21. [PMID: 19713880] Google Scholar6 National Institute of Allergy and Infectious Diseases. Pediatric H1N1 vaccine clinical studies. www3.niaid.nih.gov/topics/Flu/H1N1/Research/children.htm (accessed 24 Nov 2009). Google Scholar Author, Article, and Disclosure InformationAffiliations: University of Texas MD Anderson Cancer Center, Houston, Texas, USA (B.G.)This article was published at Annals.org on 5 January 2010. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoOne or two 7.5-µg doses of MF59-adjuvanted influenza A (H1N1) 2009 vaccine was immunogenic in adults within 21 days Bruno Granwehr Metrics 19 January 2010Volume 152, Issue 2Page: JC1-9KeywordsAntibody productionAntigensChildrenH1N1Pulmonary medicineSafetySwine influenzaVaccines ePublished: 19 January 2010 Issue Published: 19 January 2010 CopyrightCopyright © 2010 by American College of Physicians. All Rights Reserved.PDF DownloadLoading ...
AT-59 * HIGH-DOSE MTX-BASED CHEMOTHERAPY FOR PRIMARY CNS LYMPHOMA: WITH OR WITHOUT WHOLE BRAIN RADIOTHERAPY? FINAL ANALYSIS OF G-PCNSL-SG-1
Authors: M. Weller, E. Thiel, P. Martus, R. Mohle, F. Griesinger, M. Rauch, A. Roeth, B. Hertenstein, T. Fischer, T. Hundsberger, H.-G. Mergenthaler, C. Junghanss, T. Birnbaum, L. Fischer, K. Jahnke, U. Herrlinger, T. Pietsch, P. Roth, M. Bamberg, A. Korfel
Journal: Neuro-Oncology (2014)

BACKGROUND: This is the final report of the G-PCNSL-SG-1 trial after a median follow-up of 81.2 months. METHODS: G-PCNSL-SG-1 (www.clinicaltrials.gov NCT00153530) had randomised immunocompetent patients with newly diagnosed PCNSL to high-dose methotrexate (HDMTX) - based chemotherapy followed by whole-brain radiotherapy (WBRT) or chemotherapy alone. We hypothesized that the omission of WBRT from first-line treatment would not compromise overall survival (OS; primary endpoint), using a non-inferiority design with a margin of 0.9. FINDINGS: Of 551 patients who entered the study 524 fulfilled the eligibility criteria, 410 entered the post-HDMTX phase (intention-to-treat, ITT population), and 320 were treated per protocol (PP). OS with versus without WBRT was different neither in the ITT (HR 0.997, 95%CI 0.79-1.26, p = 0.98) nor in the PP population (HR 1.03, 95%CI 0.79-1.35, p = 0.82). In the ITT population CR patients experienced neither a progression-free survival (PFS) benefit from the last HDMTX-based CHT (PFS-2) (HR 0.84, 95% CI 0.60-1.19, p = 0.33) nor an OS benefit (HR 1.13, 95% CI 0.77-1.66, p = 0.53) with WBRT. In CR patients of the PP population, WBRT conferred a benefit for PFS-2 (HR 0.68, 95%CI 0.46-1.01, p = 0.057), but no OS benefit (HR 1.06, 95%CI 0.69-1.63, p = 0.78). In non-CR patients of the ITT population, a benefit of PFS-2 (HR 0.58, 95%CI 0.44-0.77, p < 0.001), but not of OS (HR 0.86, 95%CI 0.64-1.16, p = 0.32) was found with WBRT; in non-CR patients of the PP population, WBRT conferred a benefit of PFS-2 over CHT alone (HR 0.41, 95%CI 0.29-0.57, p < 0.001) and a trend for OS, too (HR 0.76, 95%CI 0.54-1.08, p = 0.12). INTERPRETATION: Despite improvement in PFS, particularly in patients without CR to HDMTX-based CHT, no significant difference in OS was found when WBRT was omitted from primary therapy in this long-term follow-up analysis. The PFS afforded by WBRT has to be balanced against its long-term toxicity.
Wnt Signaling Activation in Adipose Progenitors Promotes Insulin-Independent Muscle Glucose Uptake
Authors: Daniel Zeve, Jin Seo, Jae Myoung Suh, Drew Stenesen, Wei Tang, Eric D. Berglund, Yihong Wan, Linda J. Williams, Ajin Lim, Myrna J. Martinez, Renée M. McKay, Douglas P. Millay, Eric N. Olson, Jonathan M. Graff
Journal: Cell Metabolism (2012)
A UNIQUE CASE OF EYESTRAIN.
Authors: PERCY R. WOOD
Journal: JAMA (1907)

The eye may be designated as an end organ of the brain through which the latter discharges its visual function, thus explaining the disturbance of cerebral reflex centers by slight errors of refraction and consequent interference with various functional activities. Twenty-five per cent. of all civilized people suffer from conditions dependent on ocular malfunction and clinically described as eyestrain. A large proportion of these cases is not reached because few physicians correctly diagnose the condition, the profession, as a whole, being poorly informed on this subject. If insomnia, nervousness, headache, indigestion and constipation may result from ocular defects, the physician should know this and so be able to prescribe the proper remedy. Whenever our text-books emphasize more clearly, and our medical schools teach more explicitly, the pathogenesis of eyestrain, we may have recognized colleges for postgraduate work along these lines and laws confining the practice of opthalmology and refraction therapy
Effect of Repeated Whole Blood Donations on Serum Immunoreactive Erythropoietin Levels in Autologous Donors
Authors: Thomas S. Kickler
Journal: JAMA (1988)

The effect of repeated phlebotomy on serum immunoreactive erythropoietin levels was studied prospectively in 69 autologous blood donors. At the time of the initial phlebotomy, 11 men (33%) and two women (6%) were anemic; during the course of blood donations, anemia (defined as a hematocrit &lt;0.41 for men and &lt;0.36 for women) developed in an additional 17 men (71%) and 14 women (45%). Although there was an increase in the level of serum immunoreactive erythropoietin with successive phlebotomies, the increase was not substantially out of the normal range. The lack of an erythropoietic response to repeated phlebotomies in association with the small increment in the serum erythropoietin level was not due to iron deficiency, since the level of red-cell free protoporphyrin did not increase in these patients. We conclude that within the hematocrit range permissible for autologous blood donation, the degree of anemia experienced is insufficient to initiate an adequate increase in erythropoietin production; as a consequence, mild anemia develops in a majority of donors, and the volume of blood donated is inadequate to meet their operative needs. (<i>JAMA</i>1988;260:65-67)
Quality of Care
Authors: ROBERT G. RATE
Journal: Annals of Internal Medicine (1981)

Letters and Corrections1 August 1981Quality of CareROBERT G. RATE, M.D.ROBERT G. RATE, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-95-2-238_1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: The editorial by Lawrence (1) in the February issue makes the point that "data are lacking for . . . the quality of practitioner performance" for both family practice and primary care internal medicine. "Documentation of the quality of practice is essential . . ." but difficult.Since 1976, the medical staff of the U.S. Public Health Service Hospital in Keams Canyon, Arizona, has made an excellent attempt to document the quality of medical care practiced at this rural 35-bed Joint Commission on Accreditation of Hospitals-accredited facility. Seventeen physicians have served since 1976 as general medical officers...Reference1. LAWRENCE R. Family practice celebrates a decade of growth. Ann Intern Med. 1981;94:271-2. LinkGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Hutchinson Clinic Hutchinson, KS 67501 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 August 1981Volume 95, Issue 2Page: 238-238KeywordsHealth care facilitiesHealth care qualityMedical servicesMedical staff Issue Published: 1 August 1981 PDF DownloadLoading ...
Tibolone and the Promise of Ideal Hormone-Replacement Therapy
Authors: Ghada El-Hajj Fuleihan
Journal: New England Journal of Medicine (2008)

Since the mean life expectancy at menopause is 32.7 years, women spend more than one third of their lives in the estrogen-deficient postmenopausal state.1 Of the majority of menopausal women who have climacteric symptoms, 20% describe them as intolerable, and one third have such symptoms for up to 5 years.2 During her lifetime, one of every two women will have an osteoporotic fracture, one third will have coronary heart disease, one fifth will have a stroke or Alzheimer's disease, and one eighth will have breast cancer.Whereas hormone-replacement therapy was once accepted as the ideal strategy for optimizing postmenopausal health . . .