PLASMAPHERESIS EXPERIMENTS UPON THE INFLUENCE OF COLLOID OSMOTIC PRESSURE, WATER AND SALT IN EDEMA FORMATION
Authors: Arthur C. Kerkhof
Journal: Annals of Internal Medicine (1938)

Article1 February 1938PLASMAPHERESIS EXPERIMENTS UPON THE INFLUENCE OF COLLOID OSMOTIC PRESSURE, WATER AND SALT IN EDEMA FORMATIONARTHUR C. KERKHOF, B.S., Ph.D., M.D.ARTHUR C. KERKHOF, B.S., Ph.D., M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-11-8-1407 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptNumerous investigators have produced edema by a reduction of the plasma proteins. The reduction of the plasma proteins by repeated bleedings is called plasmapheresis. Leiter1,2and Barker and Kirk3were the first to carry on this work. Since that time numerous investigators, chiefly Shelburne and Egloff,4Lepore,5Darrow, Hopper and Carey,6Weech, Snelling and Goettsch,7Kylin8and ourselves9,10have carried on these experiments. Our method of plasmapheresis has been essentially the following: Five to eight hundred cubic centimeters of normal blood were obtained from the right or left ventricle of a normal dog. This blood was citrated, centrifuged, the plasma...Bibliography1. LEITER L: Experimental nephrotic edema, Arch. Int. Med., 1931, xlviii, 1-32. CrossrefGoogle Scholar2. LEITER L: Experimental edema, Proc. Soc. Exper. Biol. and Med., 1928, xxvi, 173-175. CrossrefGoogle Scholar3. BARKERKIRK MHEJ: Experimental edema (nephrosis) in dogs in relation to edema of renal origin in patients, Arch. Int. Med., 1930, xlv, 319-346. CrossrefGoogle Scholar4. SHELBURNEEGLOFF SAWC: Experimental edema, Arch. Int. Med., 1931, xlviii, 51-69. CrossrefGoogle Scholar5. LEPORE MJ: Experimental edema produced by plasma protein depletion, Arch. Int. Med., 1932, l, 488-505. CrossrefGoogle Scholar6. DARROWHOPPERCAREY DCEBMK: Plasmapheresis edema. Relation of reduction of serum protein to edema and pathological anatomy accompanying plasmapheresis, Jr. Clin. Invest., 1932, xi, 683-699. CrossrefGoogle Scholar7. WEECHSNELLINGGOETTSCH AACEE: Relation between plasma protein content, plasma specific gravity and edema in dogs maintained on protein inadequate diet and in dogs rendered edematous by plasmapheresis, Jr. Clin. Invest., 1933, xii, 193-216. CrossrefGoogle Scholar8. KYLIN E: Studien über den kolloidosmotischen Druck; tierexperimentelle Untersuchungen über die Bedeutung der Senkung des kolloidosmotischen Druckes für die Ödempathogenese, Arch. f. exper. Path. u. Pharmakol., 1933, clxx, 407-416. CrossrefGoogle Scholar9. FAHRKERKHOFGIERE GAE: Salt as a factor in edema formation following plasmapheresis, Proc. Soc. Exper. Biol. and Med., 1931, xxviv, 335-336. CrossrefGoogle Scholar10. FAHRKERKHOF GA: Lowered colloid osmotic pressure leads to water and salt retention and edema formation, Proc. Soc. Exper. Biol. and Med., 1933, xxx, 1212-1213. CrossrefGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: ARTHUR C. KERKHOF, B.S., Ph.D., M.D.Affiliations: Minneapolis, Minnesota*Received for publication March 29, 1937.From the Department of Medicine, University of Minnesota, at the Minneapolis General Hospital. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byPHAGEDENIC AND GANGRENOUS ULCERATION OF THE SKIN COMPLICATING ULCERATIVE COLITIS (PHAGEDENA GEOMETRICUM) 1 February 1938Volume 11, Issue 8 Page: 1407-1415 Keywords Blood Blood plasma Edema Hemorrhage Hospital medicine Left ventricle Osmotic pressure Plasma proteins Salts ePublished: 1 December 2008 Issue Published: 1 February 1938 PDF downloadLoading ...