tbuckley/cabot-search huggingface dataset:
Abstract 4103: Biomarkers of thyroid function and autoimmunity associated with thyroid cancer risk: A nested case-control study
Authors: Jeongseon Kim, Young Ae Cho, Aesun Shin, Jeonghee Lee, Sun-Young Kong, Eun Kyung Lee, You Jin Lee
Journal: Cancer Research (2014)

Abstract Background &amp; Objective: The incidence of thyroid cancer has been increased in several countries. However, the markers to predict for high-risk group have not been fully established. We aim to investigate the potential association between the biomarkers of thyroid function/autoimmunity and the risk of thyroid cancer in Korean population, where the incidence rate of thyroid cancer is one of the highest in the world. Design: This study was a nested case-control study within the Cancer Screenee Cohort study, which consisted of 257 incident thyroid cancer patients who were ascertained during mean of 2.2 years of follow-up and 257 controls. Total triidothyronine (TT3), free thyroxine (FT4), thyroid-stimulating hormone (TSH), and thyroglobulin (Tg), and two markers of thyroid autoimmunity (anti-thyroperoxidase [TPOAb] and anti-thyroglobulin [TgAb] antibodies) were measured. Logistic regression models were used to examine the association between these biomarkers and thyroid cancer risk. Stratified analyses were conducted by sex, BMI, and smoking status. Results: When the markers were categories by tertile distribution of the levels of controls group, highest tertile of FT4 (OR [95% CI] = 1.73[1.11, 2.69]) and middle tertile of TSH (OR [95% CI] = 1.77[1.14, 2.74]) were associated with thyroid cancer risk in multivariate analyses. In addition, normal (30-60 U/mL) (OR [95% CI] = 8.47 [5.39, 13.33]) or elevated levels (60 &amp;gt; U/mL) (OR [95% CI] = 4.48 [2.59, 7.76]) of TPOAb showed an elevated risk for thyroid cancer. Stratified analyses implied that some of these associations could be differed by sex, BMI, or smoking status. Conclusions: This study represented that the levels of biomarkers of thyroid function/autoimmunity, particularly the presence of TPOAb, may be used as diagnostic adjuncts for predicting thyroid cancer risk. Citation Format: Jeongseon Kim, Young Ae Cho, Aesun Shin, Jeonghee Lee, Sun-Young Kong, Eun Kyung Lee, You Jin Lee. Biomarkers of thyroid function and autoimmunity associated with thyroid cancer risk: A nested case-control study. [abstract]. In: Proceedings of the 105th Annual Meeting of the American Association for Cancer Research; 2014 Apr 5-9; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2014;74(19 Suppl):Abstract nr 4103. doi:10.1158/1538-7445.AM2014-4103
Tort Reform Focus
Authors: Mike Mitka
Journal: JAMA (2005)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Journals JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2024 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
NG-monomethyl-l-arginine inhibits erythropoietin gene expression by stimulating GATA-2
Authors: Takahisa Tarumoto, Shigehiko Imagawa, Ken Ohmine, Tadashi Nagai, Masato Higuchi, Nobuo Imai, Norio Suzuki, Masayuki Yamamoto, Keiya Ozawa
Journal: Blood (2000)
Abstract 2053: Biodegradable Small Calibre Polydioxanone-based Vascular Prostheses: Potential as Coronary Bypass Grafts
Authors: Beat H Walpoth, Mustafa Cikirikcioglu, Damiano Mugnai, Jean-Christophe Tille, Erman Pektok, Raymond Pfister, Domenico Palombo, Afksendiyos Kalangos, Gary Bowlin
Journal: Circulation (2007)

Aims : Shelf-ready synthetic small calibre prostheses are needed for coronary artery bypass grafting. Biodegradable scaffolds resistant to degradation-induced aneurysm formation in the systemic arterial circulation have been developed for in vivo vascular tissue engineering. We evaluated patency, biocompatibility and mechanical properties (remodelling) of 3 electrospun biodegradable random nano-fibre polymer prostheses: polydioxanone (PDO) alone; blended with: poly(lactic-acid) (PDO-PLA); with polycaprolactone (PDO-PCL). Methods: In 30 anaesthetised Sprague Dawley rats, 2mm ePTFE grafts controls(n=9), PDO(n=3), PDO-PLA(n=9), PDO-PCL(n=9), were interposed in the infrarenal abdominal aorta and followed for 3, 6 and 12 weeks. Digital substraction angiography was made for patency, stenosis and aneurysmal dilatation before euthanasia. Grafts were harvested for SEM, histology and computed morphometry for assessment of neo-endothelialisation and intimal hyperplasia. Results: Patency rates were excellent for all grafts (100%) and no relevant stenoses were found. Angiography follow-up showed aneurysmal formation for all PDO-alone grafts at 3 weeks (therefore no further implantations were made) and 1/3 for PDO-PLA at 6 and 12 weeks. No aneurysms were found for PDO-PCL grafts. All PDO-based grafts show slow degradation, a significantly better neoendothelialisation and insignificant neointimal formation compared to ePTFE. Conclusion(s): Patency of electrospun biodegradable PDO-based prostheses is excellent. Using slow, biodegrading polymer blends, e.g. PDO-PCL can avoid aneurysm formation and the neoendothelialisation (blood compatibility) of such prostheses is significantly better compared to ePTFE. Therefore, biodegradable, electrospun PDO-based vascular prostheses may be a promising alternative as shelf-ready cardiopulmonary bypass grafts. RESULTS AFTER 12 WEEKS IMPLANTATION:
Abstract 5147: Canine spontaneous head and neck squamous cell carcinomas represent their human counterparts at the molecular level
Authors: Deli Liu, Huan Xiong, Angela E. Ellis, Nicole C. Northrup, Dong M. Shin, Shaying Zhao
Journal: Cancer Research (2015)

Abstract Spontaneous canine head and neck squamous cell carcinoma (HNSCC) represents an excellent model of human HNSCC but is greatly understudied. To better utilize this valuable resource, we performed its first genome-wide characterization by investigating 12 canine HNSCC cases, of which 9 are oral, via high density array comparative genomic hybridization and RNA-seq. The analyses reveal that these canine cancers faithfully recapitulate many key molecular features of human HNSCC. These include similar genomic copy number abnormality landscapes, analogous sequence mutation patterns, and recurrent alteration of known HNSCC genes (e.g., MYC, CDKN2A) and pathways (e.g., cell cycle, mitogenic signaling, TGFβ signaling). Amplification or overexpression of protein kinase genes, matrix metalloproteinase genes, and epithelial-mesenchymal transition genes TWIST1 and SNAI are also prominent in these canine tumors. The strong dog-human molecular homology fundamentally justifies the use of our novel dog-human comparison strategy for driver-passenger discrimination for HNSCC. This cross-species comparison will significantly advance beyond the current findings with the massive genomic data of the cancer genome atlas (TCGA), as exemplified by our pilot study on human 8q, a recurrently amplified site in human HNSCC. HNSCC represents the sixth leading cancer by incidence in humans; thus developing effective therapeutic interventions is important. While our understanding of the biology of HNSCC has been greatly advanced over past decades, translating these findings into clinical success has been frustratingly slow. A significant obstacle is the lack of translational model that can bridge the gap between preclinical research and human clinical trials. Our study indicates that spontaneous canine HSCC can effectively bridge this gap, significantly accelerating anti-HNSCC drug discovery. Note: This abstract was not presented at the meeting. Citation Format: Deli Liu, Huan Xiong, Angela E. Ellis, Nicole C. Northrup, Dong M. Shin, Shaying Zhao. Canine spontaneous head and neck squamous cell carcinomas represent their human counterparts at the molecular level. [abstract]. In: Proceedings of the 106th Annual Meeting of the American Association for Cancer Research; 2015 Apr 18-22; Philadelphia, PA. Philadelphia (PA): AACR; Cancer Res 2015;75(15 Suppl):Abstract nr 5147. doi:10.1158/1538-7445.AM2015-5147
Costs of care associated with non-small-cell lung cancer in a commercially insured cohort.
Authors: B E Hillner, M K McDonald, C E Desch, T J Smith, L T Penberthy, P Maddox, S M Retchin
Journal: Journal of Clinical Oncology (1998)

PURPOSE To examine the cost of incident cases of non-small-cell lung cancer (NSCLC) in a commercially insured cohort. METHODS Claims from Virginia Blue Cross and Blue Shield (BCBS) beneficiaries with lung cancer from 1989 to 1991 were merged with records from the Virginia Cancer Registry (VCR). Data from the VCR identified incident cases, stage, and type of cancer at diagnosis. Costs for all medical care included insurance payment, copayments, and deductibles for 2 years after diagnosis or until death. RESULTS Three hundred forty-nine incident NSCLC patients were evaluated. The mean 2-year cost for each patient after diagnosis or until death was $47,941 (95% confidence interval, $43,758 to $52,124). Total average costs and hospital days were significantly lower for local disease ($37,514, 21.2 days), but were similar for regional ($52,797, 30.0 days) and distant ($49,382, 33.0 days) disease. Hospital days accounted for 48% and hospital-based claims for 70% of costs. Initial treatments, which included radiation, unadjusted for stage, had the lowest survival rates and the highest costs, and were associated with the most hospital days. Initial stage, race, gender, and age were not predictors of total 2-year costs. The independent predictors of total 2-year costs were type of treatment: any radiation therapy, any surgery, or any chemotherapy (all, P &lt; .001). Inpatient hospital days was only a modest predictor of costs after adjusting for type of treatment. Patients who survived less than 1 year spent 30.5 days in hospital and had an average cost of $47,280. CONCLUSION The direct health care costs of younger NSCLC patients care are substantial. These results should serve as a benchmark for future comparisons as the United States market shifts to managed care.
Perioperative considerations for patients with asthma underwent thoracic surgery
Authors: Yordanka Yamakova, Rosen Petkov, Georgi Yankov, Danail Petrov
Journal: European Respiratory Journal (2012)

Asthmatic patients are a challenging population for anesthesiologists.   The aim  of this study was to determine the perioperative complications in asthmatic patients with symptoms before the surgery.   Material and metods : From 2007 to 2011 44 patients with asthma underwent thoracotomy. We classified the patients into two groups: First group (n 19) - patients with asthma who currently have no symptoms and second group (n 25) - asthmatic patients with symptoms before surgery. Pulmonary function was optimized preoperatively in all patients and airway obstruction was controlled by using steroids and bronchodilators. We conducted deep anesthesia with Sevoflurane, Fentanyl and Pipecuronium. We monitored several parameters: tidal volume, inspiratory, expiratory volume, Ppeak, Pplat, ETCO2, PaC02.   Results:  The First group patients had less incidences of perioperative bronchospasm than those in the second (p   Conclusion:  Symptomatic asthmatic patients had more the incidence rate of the perioperative complications. With deepening anesthesia level and aggressive pharmacological management the anesthesiologist minimize the risk of complications.
Evaluation of medical thoracoscopy (MT) service at Basildon Hospital, UK
Authors: C. Nadarajah, R. Mogal, A. Kaur, D. Mukherjee
Journal: European Respiratory Journal (2014)

Background: The current British Thoracic Society guidelines 2010 recommend the use of MT for cytology negative,exudative pleural effusions,by using local anaesthesia and conscious sedation.   Aims: To evaluate the outcomes of MT and success of talc pleurodesis (TP) following MT.   Methods: A retrospective analysis of 118 patients that underwent MT.Successful pleurodesis was defined as no evidence of pleural fluid re-accumulation on a follow up chest X-ray 30 days post procedure.The instrument used was a Richard Wolf GmbH rigid 7mm thoracoscope with a 4mm for biopsy.TP was performed using Steritalc spray.   Results: Out of 118 patients,28 patients were excluded from analysis (20 patients had lack of data and in 8 patients procedure was abandoned).The avergae age of patients was 76 years.83.3% of patients had abnormal pleura (n=75).Endoscopic findings of malignant pleural involvement were mostly nodules of varying size and thickened pleura.The pathological diagnoses were as follows:primary pleural mesothelioma 36.7%(n=33),pleural metastases 28.9%(n=26),non-specific chronic inflammation 13.3%(n=12),hepatic hydrothorax 2.2%(n=2),Tuberculosis pleurisy 1.1%(n=1),and empyema 1.1%(n=1).66.7% of patients had pleurodesis (n=60) and it was successful in 71.70% of patients (n=43).12.2% of patients had complications (n=11) that included pain(n=2),trapped lungs(n=5),wound infections (n=2),skin haematoma (n=1),and surgical emphysema(n=1).The average length of stay was 3.7 days but in patients with complications it was 5.6 days.   Conclusion: MT is a relatively safe procedure for the diagnosis of patient with an exudative pleural effusion.Serious complications are rare,however,complications led to prolonged hospital stay,and therefore cost.
Isoniazid and Wound Healing
Authors: J W MARTYN, H H CAMPBELL
Journal: JAMA (1963)

In non-tuberculous patients with lesions exhibiting a delayed healing process oral isoniazid in doses of 3 mg./kg. was found to be rapidly effective in stimulating the wounded area to produce healthy granulation tissue. The prompt healing of these defects was accomplished by the formation of scar tissue which resisted stress in a superior manner. A topical ointment of 2% isoniazid in eucerin had a similar beneficial effect in patients with indolent skin ulcers who had failed to respond to routine treatment. Epithelialization rapidly ensued once the granulating base was established. A further series of patients with delayed wound healing and failure to respond to antibiotics or isoniazid alone showed satisfactory response when both measures were used simultaneously. It is postulated that isoniazid provides a stimulus to the growth of normal granulation tissue, may promote greater tensile strength in scars, and may be of benefit in antibiotic-resistant infections because of its ability to boost the host's normal repair mechanisms.
Abstract 2777: Lycopene synergistically enhances quinacrine action to inhibit Wnt-TCF signaling in breast cancer cells through APC
Authors: Ranjan Preet, Rajasubramaniam Shanmugam, Purusottam Mohapatra, Dipon Das, Shakti R. Satapathy, Michael D. Wyatt, Chanakya N. Kundu
Journal: Cancer Research (2014)

Abstract We previously reported that quinacrine (QC) has anticancer activity against breast cancer cells. Here, we report the mechanism of action of QC and its ability to inhibit Wnt-TCF signaling in two independent breast cancer cell lines. QC altered Wnt-TCF signaling components by increasing the levels of adenomatous polyposis coli (APC), DAB2, GSK-3β and axin and decreasing the levels of β-catenin, p-GSK3β (ser 9) and CK1. QC also reduced the activity of the Wnt transcription factor TCF/LEF and its downstream targets cyclin D1 and c-MYC. Using a luciferase-based Wnt-TCF transcription factor assay, it was shown that APC levels were inversely associated with TCF/LEF activity. Induction of apoptosis and DNA damage was observed after treatment with QC, which was associated with increased expression of APC. The effects induced by QC depend on APC because the inhibition of Wnt-TCF signalling by QC is lost in APC-knockdown cells, and consequently, the extent of apoptosis and DNA damage caused by QC was reduced compared with parental cells. Further, previously we have shown that QC inhibits topoisomerase, therefore we tested the effect of another topoisomerase inhibitor, etoposide, on Wnt signaling. Interestingly, etoposide treatment also reduced TCF/LEF activity, β-catenin and cyclin D1 levels commensurate with induction of DNA damage and apoptosis. Lycopene, a plant-derived antioxidant, synergistically increased QC activity and inhibited Wnt-TCF signaling in cancer cells without affecting the MCF-10A normal breast cell line. Collectively, the data suggests that QC-mediated Wnt-TCF signal inhibition depends on APC and that the addition of lycopene synergistically increases QC anticancer activity. Note: This abstract was not presented at the meeting. Citation Format: Ranjan Preet, Rajasubramaniam Shanmugam, Purusottam Mohapatra, Dipon Das, Shakti R. Satapathy, Michael D. Wyatt, Chanakya N. Kundu. Lycopene synergistically enhances quinacrine action to inhibit Wnt-TCF signaling in breast cancer cells through APC. [abstract]. In: Proceedings of the 105th Annual Meeting of the American Association for Cancer Research; 2014 Apr 5-9; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2014;74(19 Suppl):Abstract nr 2777. doi:10.1158/1538-7445.AM2014-2777
Abstract P010: Dose-Response Meta-Analysis of Arsenic Exposure and Coronary Heart Disease Risk
Authors: Katherine A Moon, Shilpi Oberoi, Aaron Barchowsky, Eliseo Guallar, Keeve E Nachman, Yu Chen, Katherine A James, Ana Navas-Acien
Journal: Circulation (2015)

Introduction: Inorganic arsenic is an established toxicant and carcinogen found in drinking water and in some foods. Exposure to high levels of arsenic in drinking water (>100 μg/L) has consistently been associated with cardiovascular disease risk. In recent years, evidence of an association between cardiovascular disease and drinking water arsenic levels that are most relevant to the U.S. general population (<100 μg/L) has been building. Several high-quality prospective cohort studies are now available. In 2013, the National Academy of Science recommended that the U.S. Environmental Protection Agency include coronary heart disease as a critical endpoint in its ongoing reevaluation of the arsenic risk assessment. One critical aspect of this assessment is the shape of the dose-response relationship across low (<50 μg/L) and moderate (50-150 μg/L) levels of arsenic. Hypothesis: We examined the hypothesis that the positive relationship between arsenic exposure and coronary heart disease risk is linear when m...
Rationale and design of MinerAlocorticoid Receptor antagonist Tolerability Study‐Heart Failure (ARTS‐HF): a randomized study of finerenone vs. eplerenone in patients who have worsening chronic heart failure with diabetes and/or chronic kidney disease
Authors: Bertram Pitt, Stefan D. Anker, Michael Böhm, Mihai Gheorghiade, Lars Køber, Henry Krum, Aldo P. Maggioni, Piotr Ponikowski, Adriaan A. Voors, Faiez Zannad, Christina Nowack, So‐Young Kim, Alexander Pieper, Nina Kimmeskamp‐Kirschbaum, Gerasimos Filippatos
Journal: European Journal of Heart Failure (2015)
Where's the chief knowledge officer?
Authors: J A M. Gray
Journal: BMJ (1998)

<h3>Aim</h3> The higher rate of Autism Spectrum Disorders (ASD) in males than females has been one of the most consistent findings. An average of 4:1 ratio has been consistently reported in several studies. However; there is little research focusing on the reasons for this disparity. Many authors relate the gender bias to the ability of girls to camouflage their symptoms. This study is attempting to measure any change in the size of the gap in our local ASD community in line with the change in population demographics over the last 8 years. <h3>Methods</h3> Our locality is a large Town that has a highly diverse and highly mobile multi-ethnic community. It has a high level of both internal and international migration. Children aged 0–19 years with a diagnosis of Autistic Spectrum Disorders were recruited from the electronic database of our local NHS records (2009 −2017). We analysed data (n=1370) by age at diagnosis and sex of the child over a period of 8 years. <h3>Results</h3> The overall annual trend of the diagnosis of autism was rising steadily but the average ratio between males and females remained constant around 5:1. White children constituted the largest ethnic group at 54% <h3>Conclusion</h3> Gender difference between boys and girls with autism has not changed despite the significant change in demographics of our population over the period of 8 years, the increased level of public awareness of the condition and the improvement of professionals’ ability in early detection and diagnosis of autistic spectrum disorders. Further research is required to explain this gap
Increased Late Mortality After Sirolimus-Eluting Stents Versus Bare-Metal Stents in Diseased Saphenous Vein Grafts
Authors: Paul Vermeersch, Pierfrancesco Agostoni, Stefan Verheye, Paul Van den Heuvel, Carl Convens, Frank Van den Branden, Glenn Van Langenhove
Journal: Journal of the American College of Cardiology (2007)
Association of Baseline Characteristics and Early Vision Response with 2-Year Vision Outcomes in the Comparison of AMD Treatments Trials (CATT)
Authors: Gui-shuang Ying, Maureen G. Maguire, Ebenezer Daniel, Frederick L. Ferris, Glenn J. Jaffe, Juan E. Grunwald, Cynthia A. Toth, Jiayan Huang, Daniel F. Martin
Journal: Ophthalmology (2015)