tbuckley/cabot-search huggingface dataset:
Relationship of Gene Expression in the Injured Human Meniscus to Body Mass Index: A Biologic Connection Between Obesity and Osteoarthritis
Authors: Muhammad Farooq Rai, Debabrata Patra, Linda J. Sandell, Robert H. Brophy
Journal: Arthritis & Rheumatology (2014)

Higher body mass index (BMI) increases the risk of meniscus injury and knee osteoarthritis (OA). However, it is unknown if and how obesity affects meniscus biology. We analyzed transcriptome-wide gene expression profiles of injured human menisci to test the hypothesis that meniscal gene expression signatures relate to patient BMI. Meniscus samples were obtained from patients undergoing arthroscopic partial meniscectomy. Transcriptome-wide analysis of gene expression followed by validation of selected transcripts by QuantiGene Plex assay was performed. Correlations of gene expression with BMI and relative fold changes (≥1.5-fold) in 3 BMI categories (lean [BMI 18.5-24.9 kg/m(2) ], overweight [BMI 25.0-29.9 kg/m(2) ], and obese [BMI >30.0 kg/m(2) ]) were analyzed, and integrated functional classifications were probed computationally. The obese versus overweight comparison resulted in the largest set of differences (565 transcripts) followed by obese versus lean (280 transcripts) and overweight versus lean (125 transcripts). Biologic reproducibility was confirmed by cluster analysis of expressed transcripts. Differentially regulated transcripts represented important functional classifications. Transcripts associated with oxygen transport, calcium ion binding, and cell homeostasis were elevated with BMI, while those related to extracellular matrix deposition, cell migration, and glucosamine metabolic processes were repressed. While these functional classifications may play key roles in cartilage/meniscus homeostasis, failure of extracellular matrix deposition and increase in calcium ion binding likely contribute to OA development following meniscal injury. Our results indicate greater differences in gene expression between obese and overweight groups than between overweight and lean groups. This may indicate that there is a weight threshold at which injured meniscus responds severely to increased BMI. BMI-related changes in gene expression present a plausible explanation for the role of meniscal injury in OA development among obese patients.
Warning for Hepatitis C Treatments Given With Amiodarone
Authors: Rita Rubin
Journal: JAMA (2015)

Life-threatening symptomatic bradycardia can occur when the antiarrhythmia drug amiodarone is taken with either of 2 hepatitis C treatments containing sofosbuvir in combination with another direct-acting antiviral drug, the Food and Drug Administration (FDA) has warned (http://1.usa.gov/1xBtd8o).
Abstract 10466: In Vivo Reprogramming of Murine Cardiac Fibroblasts into Induced Cardiomyocytes
Authors: Li Qian, Yu Huang, Amy Foley, Vasanth Vedantham, Ian Spencer, Simon J Conway, Jidong Fu, Deepak Srivastava
Journal: Circulation (2011)

Li Qian, 2011 Finalist and Presenting Author
FATALITY FOLLOWING PENICILLIN INJECTION
Authors: S FISHER
Journal: Annals of Internal Medicine (1954)

Case Reports1 June 1954FATALITY FOLLOWING PENICILLIN INJECTIONSEYMOUR FISHER, M.D.SEYMOUR FISHER, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-40-6-1227 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe use of penicillin is so common, and fatal reaction to the drug so rare, that such an end result is of interest to the profession. The following case is interesting in that death occurred almost instantaneously in a seemingly healthy individual with no apparent allergic background.CASE REPORTHistory: This 28 year old white male was admitted to the Veterans Administration Hospital, Phoenix, Arizona, on July 21, 1953, for correction of a right fifth hammer toe, present since birth. A complete history and physical examination showed no significant abnormalities other than the hammer toe.Laboratory:Routine blood, urinalysis and...Bibliography1. Thomson WO: Sudden death following an injection of penicillin, Brit. M. J. 2: 70, 1952. CrossrefMedlineGoogle Scholar2. HigginsRothchild GATP: Fatal anaphylactic shock from procaine penicillin, New England J. Med. 247: 644, 1952. CrossrefMedlineGoogle Scholar3. KernWimberley RANA: Penicillin reactions: their nature, growing importance, recognition, management and prevention, Am. J. M. Sc. 226: 357, 1953. CrossrefMedlineGoogle Scholar4. FeinbergFeinbergMoran SMARCF: Penicillin anaphylaxis, nonfatal reactions, J. A. M. A. 152: 114, 1953. CrossrefMedlineGoogle Scholar5. ChristensonHedrickSchugmann WNGWRF: Fatal anaphylactic reaction following penicillin injection, U. S. Armed Forces M. J. 4: 249, 1953. MedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Phoenix, Arizona*Received for publication December 22, 1953.From Veterans Administration Hospital, Phoenix, Arizona. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByPENICILLINAkute Nebenreaktionen auf Penicillinpräparate1Die krampferregenden Eigenschaften des Penicillins bei unmittelbarer Einwirkung auf die nerv�se SubstanzComplications of antibiotic therapy 1 June 1954Volume 40, Issue 6Page: 1227-1230KeywordsAutopsyBirthBloodDrugsGratitudePathologistsPenicillinResearch laboratories Issue Published: 1 June 1954 PDF DownloadLoading ...
Ras as a target for exploratory study of monoterpene perillyl alcohol intranasal administration in patients with recurrent gliomas
Authors: Clovis Fonseca, Thereza Santos
Journal: Clinical Cancer Research (2008)

B45   This work discusses intranasal delivery of perillyl alcohol (POH) as a potential adjuvant therapeutic strategy for patients with relapsing malignant gliomas. POH is a monoterpene with preclinical antitumor activity in several types of tumor in rodent models and is currently under phase I and phase II clinical trials. The proposed mechanism of action involves inhibition of post-translational isoprenylation of small G proteins, including p21-Ras, thereby blocking signal transduction. Deregulated p21-Ras function, as a result of mutation, overexpression or growth factor-induced overactivation, contributes to growth of malignant gliomas. Intranasal delivery is a practical and non-invasive approach that allows therapeutic agents which do not cross the blood-brain barrier (BBB) to enter the Central Nervous System (CNS), reducing unwanted systemic side effects. Applying this method we performed a phase I / II study of POH in patients with relapsed malignant gliomas after standard treatment: surgery, radiotherapy and chemotherapy. POH was administrated in concentration 0.3% volume/volume (55mg) 4 times daily. The objective of this study was to evaluate the toxicity and progression-free survival after 6 months of treatment. The cohort consisted of thirty-seven patients including 29 with glioblastoma multiform (GBM), 5 with grade III astrocytoma (AA) and 3 with anaplastic oligodendroglioma (AO). Neurological examination and suitable image analysis (tomography - CT, magnetic resonance - MRI) established disease progression.  Complete Response  was defined as neurological stability or improvement conditions, disappearance of CT/MRI tumor image and corticosteroid withdraw;  Partial Response  defined as ≥ 50% reduction of CT/MRI tumor image, neurological stability or improvement conditions and corticosteroid requirement;  Progressive Course  was defined as ≥ 25% increase CT/MRI tumor image or appearance of a new lesion;  Stable Disease  was defined as lack of any changes in the CT/MRI tumor image or neurological status. After 6 months of treatment it was observed the following:  Partial Response:  3.4% (n=1) with GBM and 33,3% (n=1) with AO;  Stable Disease:  44.8% (n=13) with GBM, 60% (n=3) with AA and 33.3% (n=1) with AO;  Progressive Course:  51.7% (n= 15) with GBM, 40% (n=2) with AA and 33.3% (n=1) AO. The progression free survival (sum of partial responses and stable disease) was 48.2% for patients with GBM, 60% for AA patients and 66.6% for AO patients. The present work indicate for the first time, that intranasal administration of the signal transduction inhibitor, perillyl alcohol, is a safe, non invasive, low cost and regression of tumor size in some patients is suggestive of antitumor activity.  .
A neuroanatomical hypothesis for panic disorder
Authors: J M Gorman, M R Liebowitz, A J Fyer, J Stein
Journal: American Journal of Psychiatry (1989)

Anxiety disorders, the most common psychiatric conditions in the United States, have generated a great deal of research and scientific debate. Panic disorder, the best-studied anxiety disorder, is often believed to be either a biological disease or a psychological disease. The authors present a neuroanatomical model of panic disorder that attempts to reconcile these views. The model locates the three components of the disease--the acute panic attack, anticipatory anxiety, and phobic avoidance--in three specific sites of the CNS: the brainstem, limbic system, and prefrontal cortex, respectively. The authors suggest experiments to test their model.
Doctor's Amnesia
Authors: Frederick Foote
Journal: JAMA (2006)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The Acyclic Nucleoside Phosphonates (ANPs): Antonín Holý's Legacy
Authors: Erik De Clercq
Journal: Medicinal Research Reviews (2013)

Abstract The name of Antonín Holý has become synonymous for the era of acyclic nucleoside phosphonates (ANPs), which started with ( S )‐HPMPA as the prototype and ( S )‐HPMPC (cidofovir) as the first marketed compound. It has now evolved to a number of compounds clinically used in the treatment of HIV and hepatitis B virus infections, either as such [tenofovir disoproxil fumarate (TDF, Viread®)] or in combination [Truvada®, Atripla®, Complera®, Stribild®]. Truvada has also been approved for the prevention of HIV infections. Forthcoming is a new formulation of tenofovir (TAF: tenofovir alafenamide). Also forthcoming are several “quad” drug combinations containing either TDF or TAF. Other ANPs, based on either an alkoxy side chain or 5‐azacytosine heterocycle seem highly promising and worth further pursuing.
Abstract 14215: Percutaneous Coronary Angioplasty of Chronic Total Occlusions. Is There a Learning Curve ?
Authors: Yves Louvard, Philippe Garot, Sanjay Sastry, Aleem Khand, Thierry Unterseeh, Thomas Hovasse, Hakim Benamer, Marie-Claude Morice, Bernard Chevalier, Thierry Lefevre
Journal: Circulation (2010)

Purpose: Percutaneous coronary angioplasty (PCI) of Coronary Chronic Total Occlusions (CTO) is still associated with a reduced success rate. Lesion- and patient- related factors of failure are well known, but the influence of operator experience influence has been less described. The purpose of this abstract is to describe the influence of the operator and known predictive factors on the success rate of CTO PCI (European CTO club definition) treated by several operators in our institution. Methods: The study included 1,000 consecutive CTO PCI performed between Jan2004 and Dec 2009 by 13 operators. In order to assess the learning curve, an index of individual operator experience during the study was defined as 1 for the first 50 cases, 2 for next fifty, up to 6 for operators with > 250 cases. PCI performed by the 2 main operators were compared with 11 others. Results: A multivariate logistic regression analysis was performed in the whole population using all factors with a p value <0.2 by univariate analys...
Abstract 8980: Effective Cardiac Resynchronization Therapy May Normalize Longitudinal Dyssynchrony Evaluated by 3-Dimentional Speckle Tracking Imaging
Authors: Yasuharu Lee, Masami Nishino, Takahiro Yoshimura, Daisuke Nakamura, Masayuki Taniike, Nobuhiko Makino, Hiroyasu Katou, Yasuyuki Egami, Ryu Shutta, Jun Tanouchi, Yoshio Yamada
Journal: Circulation (2011)

Background: Cardiac resynchronization therapy (CRT) becomes standard therapy for severe heart failure and its indication is now spreading to mild to moderate heart failure. However there remains approximately 30% non-responders and the mechanism of reverse remodeling induced by CRT is still unclear. Thereby we investigated which kind of dyssynchrony parameter, existing during own beat, was improved by CRT-on. Methods: We investigated 43 patients by 3-dimentional speckle tracking imaging (3DSTI) (ARTIDA, TOSHIBA Medical System): 12 CRT responders, defined as left ventricular end-systolic volume reduction &gt;15% at 6 months after CRT, 14 CRT non-responders and age matched 17 healthy normal controls. Radial strain, longitudinal strain and circumferential strain were investigated and we calculated the following 3DSTI parameter: strain delay index (SDI) which was defined as the sum of the difference between peak and end-systolic each parameter across 16 segments. 3DSTI was investigated at &gt;6months after CRT implantation and evaluated during CRT-off as own beat and CRT-on for responders and non-responders and during sinus rhythm for normal controls to estimate CRT effect at chronic phase. Results: During CRT-off, radial and longitudinal SDI were significantly higher in responders than non-responders, but circumferential SDI was not significantly different. After turning CRT-on, radial and longitudinal SDI were improved to lose significant difference, but circumferential SDI showed significant difference. Turning CRT-on, longitudinal SDI of responders had no more significant difference with normal controls (figure). Conclusions: Effective CRT pacing at chronic phase improves radial and longitudinal dyssynchrony, especially longitudinal SDI tend to be normalized. Reverse remodeling after CRT might be induced by improvement of longitudinal dyssynchrony.
Infection and the development of allergic disease
Authors: P. G. Holt
Journal: Allergy (2011)

To cite this article: Holt PG. Infection and the development of allergic disease. Allergy 2011; 66 (Suppl. 95): 13–15. Abstract Persistent allergic diseases exemplified by atopic asthma frequently begin during very early life. Epidemiological findings indicate that progression from allergic sensitization to atopic asthma occurs most frequently when atopy is accompanied by early respiratory viral infections. The underlying mechanism appears to involve recruitment of atopy‐associated effector mechanisms into the host response to the virus. This has the dual effect of antagonising anti‐viral immunity and amplifying inflammation in the infected airway mucosa, driving asthma pathogenesis. Immune responses underlying the allergic state are uniquely plastic during childhood. Alleviating specific allergy during this period may reduce risk of subsequent asthma development.
Monoclonal Antibody to Human Osteosarcoma: A Novel Mr 26,000 Protein Recognized by Murine Hybridoma TMMR-2
Authors: Tsai Cc, McGuire Mh, Mellitt Rj, Ritter Ra rd, Xu Jz, Litwicki Dj, Roodman St
Journal: Cancer Research (1990)

Abstract  Three murine hybridomas (TMMR-1-3) were developed by repeated immunizations of mice with four different human osteosarcoma cell lines in an alternating sequence of inoculations. The monoclonal antibodies were screened for reactivities to cultured cell lines and tissue sections of osteosarcomas using flow cytometry and immunohistochemical techniques. TMMR-2 is a highly specific antibody (IgG1) that reacted with all 14 osteosarcoma tumors and eight human osteosarcoma cell lines tested, including the established human osteosarcoma cell lines HOS and Saos-2. Benign neoplastic cells from two osteoblastomas, osteoblasts from regions of reparative osteoid formation and neonatal new bone, are also reactive with TMMR-2. TMMR-1 has mesenchymal specificity while TMMR-3, although reactive with osseous differentiated cells, also reacted with mitotic cells of all cell types. Characterization of antigen structure by Western immunoblotting revealed that TMMR-2 reacted with a 100°C heat labile mercaptoethanol-sensitive Mr 26,000 protein, and TMMR-3 recognized a mercaptoethanol-resistant Mr 97,000 protein whereas TMMR-1 reacted with a series of bands from 65,000 to 85,000 molecular weight, all of which were mercaptoethanol sensitive. TMMR-1 and TMMR-2 monoclonal antibodies showed complement-independent inhibition of [3H]thymidine incorporation into DNA, but did not exhibit cytotoxic activity. The results suggest that TMMR-2 is a specific antibody that recognizes an osteoblast/osteocyte surface antigen present in normal, reactive, and neoplastic disorders of bone. The inhibitory effects on DNA synthesis in cultured osteosarcoma cells by TMMR-2 indicate an important cell growth/proliferation role of this surface antigen. These monoclonal antibodies, in combination with other known antibodies, can be used to characterize mesenchymal cell surface antigenic structure and differentiation.
THE CONCEPT OF PSYCHOSOMATIC RHEUMATISM
Authors: James L. Halliday
Journal: Annals of Internal Medicine (1941)

Article1 October 1941THE CONCEPT OF PSYCHOSOMATIC RHEUMATISMJAMES L. HALLIDAY, M.D.JAMES L. HALLIDAY, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-15-4-666 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe results of psychological, particularly medical psychological investigation, pass through three stages of opposition, like a bill in Parliament. At the first reading they are said to be absolutely untrue; at the second reading, they are said to be abnormal and improper; at the third reading they are said to be trivialities well-known to everybody since the Flood.—DR. MAJOR GREENWOOD.How do we differentiate between "true fibrositis" and "psychoneurotic rheumatism"? Before attempting to answer this question it is wise to consider the meaning usually attached to each of these terms.DEFINITIONSFibrositis. This word stands for the idea that subjective...References HALLIDAY JL: Psychological factors in rheumatism, a preliminary study, Brit. Med. Jr., 1937, i, 213 and 264. The psychological approach to rheumatism, Proc. Roy. Soc. Med., 1938, xxxi, 167. The rising incidence of psycho-somatic illness, Brit. Med. Jr., 1938, ii, 11. Proc. Roy. Soc. Med., 1937, 1938, xxi, 167. Report on the recent incidents of psycho-somatic illness, 1938. CrossrefGoogle Scholar KRETSCHMER : Brit. Med. Jr., 1937, ii, 574. CrossrefGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Glasgow,*Received for publication May 27, 1941. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byStruggling to Meet the Bar: Occupational Progress Failure and Informal Leadership BehaviorThe question of symptom lateralization in conversion disorderLaterality in SomatizationFibromyalgiaAn historical perspective on low back pain and disabilityTHE ARGUMENTS ABOUT RSI: AN EXAMINATIONDevelopment of criteria for the diagnosis of fibrositisPsychosocial Status in Chronic IllnessA Psychosomatic Approach to Rheumatoid Arthritis: A Clinical Study of 100 Female PatientsThe Neurotic Arthralgia and Myalgia SyndromeHypochondriasis: A Clinical StudyA Clinical Study of a Group of Accident-prone WorkersDiscussion on Psychogenic RheumatismNeuromuscular and Joint Diseases and the Psychosomatic ApproachArthritis in the Mediterranean Theater of OperationsPsychosomatic Non-Articular RheumatismPsychogenic Rheumatism: The Musculoskeletal Expression of PsychoneurosisThe Management of Chronic Arthritis and other Rheumatic Diseases among Soldiers of the United States ArmyRheumatoid Arthritis: ReviewFibrositis and RealityCONCEPT OF A PSYCHOSOMATIC AFFECTION 1 October 1941Volume 15, Issue 4Page: 666-677KeywordsFibromyalgia ePublished: 1 December 2008 Issue Published: 1 October 1941 PDF downloadLoading ...
Glycemic Control and Health Care Costs for Patients With Diabetes—Reply
Authors: Len Pogach
Journal: JAMA (2001)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal