tbuckley/cabot-search huggingface dataset:
THIOURACIL IN ACUTE THYROIDITIS
Authors: R C CANTWELL
Journal: Annals of Internal Medicine (1948)

Case Reports1 October 1948THIOURACIL IN ACUTE THYROIDITISROGER C. CANTWELL, M.D.ROGER C. CANTWELL, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-29-4-730 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptAcute thyroiditis has been treated in a few instances with thiouracil1 and the results have been very encouraging. The following two cases are reported to show the striking response to this drug after a thorough and adequate course of penicillin and sulfadiazine had failed to relieve any of the signs or symptoms.CASE REPORTSCase 1. A female, married, age 38, was seen on September 1, 1945, with a history of frequent chills and fever occurring, especially at night, during the preceding 10 weeks. She complained of an aching feeling in the head, pain in the neck in the thyroid...Bibliography1. KINGROSELLINI BTLJ: Treatment of acute thyroiditis with thiouracil, Jr. Am. Med. Assoc., 1945, cxxix, 267. CrossrefGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: ROGER C. CANTWELL, M.D.Affiliations: Shawano, Wisconsin*Received for publication March 12, 1947.†Deracil used in case 1 was supplied by Lederle Laboratories. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byACUTE INFLAMMATIONS OF THE THYROID GLANDSubacute and Chronic Granulomatous ThyroiditisSubacute thyroiditisSubacute Diffuse ThyroiditisSUBACUTE GRANULOMATOUS THYROIDITIS: A REVIEW*FRANZ U. STEINBERG, M.D., F.A.C.P.ACUTE THYROIDITIS TREATED WITH CORTISONE*S. LLOYD TEITELMAN, M.D., EDWARD F. ROSENBERG, M.D., F.A.C.P.Diseases of the Thyroid Gland 1 October 1948Volume 29, Issue 4Page: 730-732KeywordsDrugsEmotionsFeversPenicillinSigns and symptomsThyroid ePublished: 1 December 2008 Issue Published: 1 October 1948 PDF downloadLoading ...
Evaluation by Multivariate Analysis of the Differentiation Inhibitory Factor nm23 as a Prognostic Factor in Acute Myelogenous Leukemia and Application to Other Hematologic Malignancies
Authors: Akihiro Yokoyama, Junko Okabe-Kado, Naoki Wakimoto, Hirofumi Kobayashi, Akiko Sakashita, Nobuo Maseki, Tsuyoshi Nakamaki, Ken-ichiro Hino, Shigeru Tomoyasu, Nobuyoshi Tsuruoka, Kazuo Motoyoshi, Naokazu Nagata, Yoshio Honma
Journal: Blood (1998)
The socio‐economic burden of asthma is substantial in Europe
Authors: S. Accordini, A. Corsico, I. Cerveri, D. Gislason, A. Gulsvik, C. Janson, D. Jarvis, A. Marcon, I. Pin, P. Vermeire, E. Almar, M. Bugiani, L. Cazzoletti, E. Duran‐Tauleria, R. Jõgi, A. Marinoni, J. Martínez‐Moratalla, B. Leynaert, R. De Marco
Journal: Allergy (2007)

Background: Few data are available on the asthma burden in the general population. We evaluated the level and the factors associated with the asthma burden in Europe. Methods: In 1999–2002, 1152 adult asthmatics were identified in the European Community Respiratory Health Survey (ECRHS)‐II and the socio‐economic burden (reduced activity days and hospital services utilization in the past 12 months) was assessed. Results: The asthmatics with a light burden (only a few reduced activity days) were 13.2% (95% CI: 11.4–15.3%), whereas those with a heavy burden (many reduced activity days and/or hospital services utilization) were 14.0% (95% CI: 12.1–16.1%). The burden was strongly associated with disease severity and a lower quality of life. Obese asthmatics had a significantly increased risk of a light [relative risk ratio (RRR) = 2.17; 95% CI: 1.18–4.00] or a heavy burden (RRR = 2.77; 95% CI: 1.52–5.05) compared with normal/underweight subjects. The asthmatics with frequent respiratory symptoms showed a threefold (RRR = 2.74; 95% CI: 1.63–4.61) and sixfold (RRR = 5.76; 95% CI: 3.25–10.20) increased risk of a light or a heavy burden compared with asymptomatic asthmatics, respectively. Moreover, the lower the forced expiratory volume in 1 s % predicted, the higher the risk of a heavy burden. The coexistence with chronic cough/phlegm only increased the risk of a heavy burden (RRR = 1.88; 95% CI: 1.16–3.06). An interaction was found between gender and IgE sensitization, with nonatopic asthmatic females showing the highest risk of a heavy burden (21.6%; 95% CI: 16.9–27.1%). Conclusions: The asthma burden is substantial in Europe. A heavy burden is more common in asthmatics with obesity, frequent respiratory symptoms, low lung function, chronic cough/phlegm and in nonatopic females.
Spirituality and religion in oncology
Authors: John R. Peteet, Michael J. Balboni
Journal: CA A Cancer Journal for Clinicians (2013)

Abstract Despite the difficulty in clearly defining and measuring spirituality, a growing literature describes its importance in oncology and survivorship. Religious/spiritual beliefs influence patients' decision‐making with respect to both complementary therapies and aggressive care at the end of life. Measures of spirituality and spiritual well‐being correlate with quality of life in cancer patients, cancer survivors, and caregivers. Spiritual needs, reflective of existential concerns in several domains, are a source of significant distress, and care for these needs has been correlated with better psychological and spiritual adjustment as well as with less aggressive care at the end of life. Studies show that while clinicians such as nurses and physicians regard some spiritual care as an appropriate aspect of their role, patients report that they provide it infrequently. Many clinicians report that their religious/spiritual beliefs influence their practice, and practices such as mindfulness have been shown to enhance clinician self‐care and equanimity. Challenges remain in the areas of conceptualizing and measuring spirituality, developing and implementing training for spiritual care, and coordinating and partnering with chaplains and religious communities. CA Cancer J Clin 2013;63:280–289 . © 2013 American Cancer Society .
Abstract 13655: Factors Influencing the Occurrence of Cardiopulmonary Arrest in the Great East Japan Earthquake Disaster
Authors: Kiyotaka Hao, Jun Takahashi, Tatsuo Aoki, Satoshi Miyata, Taro Nihei, Shunsuke Nishimiya, Ryuji Tsuburaya, Yasuharu Matsumoto, Kenta Ito, Yasuhiko Sakata, Hiroaki Shimokawa
Journal: Circulation (2014)

Background:  We have previously reported that the Great East Japan Earthquake increased the occurrence of cardiopulmonary arrest (CPA). In this study, we assessed the factors influencing the occurrence of CPA of presumed cardiac origin in the Disaster.   Methods and Results:  We enrolled all patients with CPA of presumed cardiac origin by using the ambulance transport records database of Miyagi Prefecture, the center of the Disaster area, from February 11 to June 30 of 2008-2011 (n=2,534) and compared the weekly occurrences in 2011 with those in the previous 3 years. In the whole patients, the weekly occurrence of CPA was significantly increased with the bimodal peaks noted in the first 2 weeks after the Earthquake (March 11, 2011) and in the week just after the largest aftershock (April 7, 2011) compared with the previous 3 years. Sub-group analyses for sex, age (   Conclusions:  These results indicate that the increase in the occurrence of CPA after the Earthquake was influenced by sex, age, and residence, providing a clue to reduce CPA in future disasters.
Pulmonary Vein Total Occlusion Following Catheter Ablation for Atrial Fibrillation
Authors: Luigi Di Biase, Tamer S. Fahmy, Oussama M. Wazni, Rong Bai, Dimpi Patel, Dhanunjaya Lakkireddy, Jennifer E. Cummings, Robert A. Schweikert, J. David Burkhardt, Claude S. Elayi, Mohamed Kanj, Lucie Popova, Subramanya Prasad, David O. Martin, Lourdes Prieto, Walid Saliba, Patrick Tchou, Mauricio Arruda, Andrea Natale
Journal: Journal of the American College of Cardiology (2006)
Abstract MP63: Randomized Trials of Low-Fat vs. Other Diet Interventions on Weight Loss: A Meta-Analysis
Authors: Deirdre K Tobias, Mu Chen, Walter Willett, Frank B Hu
Journal: Circulation (2014)

Introduction: The effectiveness of low-fat diets for weight loss has been debated for decades. Dozens of randomized control trials (RCTs) have assessed whether decreasing the intake of total fat leads to weight loss, giving mixed results. Hypothesis: We hypothesized that low-fat dietary interventions do not lead to greater weight loss when comparator diet intervention intensity is considered. Methods: We conducted a systematic review and meta-analysis. RCTs were included if they compared a low-fat dietary intervention to any control diet with at least 1 year of follow-up. We estimated the combined fixed effect inverse variance weighted mean difference of low-fat vs. comparison diets. Several a priori stratified analyses were considered to explore heterogeneity. Results: Fifty studies met inclusion criteria, reporting 1-10 years of follow-up on 70,054 participants. Overall, low-fat dietary interventions resulted in 0.51kg greater weight loss compared to other diets (95% CI = -0.62, -0.40, p&lt;0.001; I2 = 83%). However, when trials where greater attention was given to the low-fat group were excluded, comparator diets led to greater weight loss than low-fat diets (n=30; WMD=0.87, 95% CI=0.56, 1.17, p&lt;0.001). Similarly, when the type of comparator diet was considered, low-fat diets were only beneficial compared to control groups who were simply asked to maintain their usual diet (n=18; WMD = -1.03, 95% CI = -1.18, -0.88, p&lt;0.001). When equal attention was given to intervention groups, low-carbohydrate diets (n=15; WMD = 1.13kg, 95% CI = 0.53, 1.73, p&lt;0.001) and other “healthy” diets without a low-fat component (n=20; WMD = 0.77kg, 95% CI = 0.42, 1.13, p&lt;0.001) led to greater weight loss than low-fat diets. Comparison diets, irrespective of type, were associated with 1.30kg greater weight loss than low-fat diets when the interventions were intended to be isocaloric (n=19; 95% CI = 0.92, 1.69, p&lt;0.001). Conclusions: Low-fat dietary interventions are not more effective than other diets for weight loss when differences in intervention intensity between treatment groups are considered. Rather, evidence from long-term (&gt;=1 year) randomized trials indicates low-carbohydrate or other healthful dietary pattern interventions without a low-fat focus may be more effective for weight loss than low-fat dietary interventions. Further evidence is needed to establish the role of these interventions in longer-term weight loss and weight maintenance.
85. High-Level Expression of Wild-Type p53 from the Novel p53-Responsive pCLPG Retrovirus Halts the Proliferation of Tumor Cells Regardless of Their p53 Status
Authors: Bryan E. Strauss, Marcio C. Bajgelman, Eugenia Costanzi-Strauss
Journal: Molecular Therapy (2004)

One of the barriers to the success of gene therapy is appropriate and adequate expression of the therapeutic gene by the vector. Although retroviral vectors have been widely used in both laboratory and clinical gene transfer studies, many reports in the literature indicate that retroviral vectors suffer silencing of transgene expression in vivo and that modification of the LTR is necessary in order to restore reliable transcription. To this end, we have constructed a retroviral gene transfer system with a modified LTR such that transactivation is mediated by the tumor suppressor p53. Our approach may be beneficial for the achievement of high-level transgene expression as well as inducible transactivation. Ex vivo applications of the pCLPG system would rely on endogenous p53 to drive viral expression implying that stimulation of p53 would result in increased transgene levels (Figure 1A). This transcriptional mechanism, in combination with drug resistance genes, may prove beneficial for the protection of the hematopoietic system from the effects of chemotherapy. In situ applications may benefit from the positive feedback mechanism established by the combination of the p53-responsive LTR plus virally encoded p53, resulting in high-level p53 expression and subsequent suppression of tumor cell proliferation (Figure 1B).
Cytokine profiles of BAL T cells and T‐cell clones obtained from human asthmatic airways after local allergen challenge
Authors: K.J. Bodey, A.E. Semper, A.E. Redington, J. Madden, L.M. Teran, S.T. Holgate, A.J. Frew
Journal: Allergy (1999)

This study assessed the heterogeneity of cytokine expression in asthma before and after local allergen challenge.BAL T cells were obtained 10 min or 24 h after local endobronchial allergen challenge in atopic asthmatic subjects. T cells were cloned by direct limiting dilution. mRNA expression was assessed by RT-PCR, and cytokine protein production by ELISA.Unstimulated baseline BAL T cells expressed mRNA for IFN-gamma, IL-13, and TNF-alpha. A minority of samples expressed IL-4 and IL-5, but no IL-3 mRNA was detected. PHA stimulation increased expression of IL-3, IL-4, and IL-5 mRNA in 4/6 samples. IL-13 and GM-CSF mRNA were found in BAL cells after allergen challenge, but expression of IFN-gamma was reduced. Both IL-4 and IL-3 were strongly upregulated after PHA stimulation, while the expression of TNF-alpha and IFN-gamma was reduced, compared to equivalent baseline samples. Seventeen panels of BAL T-cell clones were derived (average cloning efficiency 1/40 T cells). Seven panels survived to 8 weeks for analysis. Clones derived 4 h after saline challenge showed strong mRNA signals for IL-13, IL-4, and IFN-gamma, whereas clones derived 24 h after allergen challenge expressed IL-13, GM-CSF, IL-3, IL-4, and often IL-5 (i.e., closer to the Th2 profile). There was considerable heterogeneity in the patterns of cytokine mRNA and protein production by different clones.T cells from asthmatic airways produce IL-13, IFN-gamma, and TNF-alpha, but after allergen challenge, type 2 cytokines are upregulated. mRNA and protein analysis provide complementary information on airways T-cell cytokine profiles.
Hemolysis of transfused group O red blood cells in minor ABO- incompatible unrelated-donor bone marrow transplants in patients receiving cyclosporine without posttransplant methotrexate
Authors: JL Gajewski, LD Petz, L Calhoun, S O'Rourke, EM Landaw, NR Lyddane, LA Hunt, GJ Schiller, WG Ho, RE Champlin
Journal: Blood (1992)
A gene encoding a novel RFX-associated transactivator is mutated in the majority of MHC class II deficiency patients
Authors: Krzysztof Masternak, Emmanuèle Barras, Madeleine Zufferey, Bernard Conrad, Garry Corthals, Ruedi Aebersold, Jean-Charles Sanchez, Denis F. Hochstrasser, Bernard Mach, Walter Reith
Journal: Nature Genetics (1998)
Healing of Abiku Children
Authors: M Therese Southgate
Journal: JAMA (2005)

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A Review of: “Max Mehlman. 2003.Wondergenes: Genetic Enhancement and the Future of Society.”
Authors: Daniel Vorhaus
Journal: The American Journal of Bioethics (2005)

“Democracy is a thing of the past. Society succumbs to tyranny or chaos as the genobility struggles to maintain its hegemony and the unenhanced strive to overthrow their rulers.” Mehlman's vision o...
Airway measurements in tracheobronchial stenosis using endobronchial ultrasonography during stenting
Authors: Seiichi Nobuyama, Naoki Furuya, Hiroshi Handa, Hiroki Nishine, Noriaki Kurimoto, Teruomi Miyazawa
Journal: European Respiratory Journal (2011)

Purpose:  To assess airway measurements, endobronchial ultrasonography (EBUS) and multi-detector low computed tomography (MDCT) images are compared in patients with tracheal stenosis.   Methods:  Airway stenting was performed on 31 patients, 25 malignant and 6 benign. EBUS and MDCT images were compared before intervention to assess the narrowing airway at 212 sites. Of these, 130 sites were considered normal and 82 abnormal. For malignant stenosis, airway measurements were taken at 160 sites including 112 normal and 48 abnormal. For benign stenosis, airway measurements were taken at 52 sites including 18 normal and 34 abnormal. This technique enables the EBUS probe to measure the distal end to proximal end of the stenosis whereby the inflated balloon size changes according to the degree of stenosis.   Results:  The diameter and length of stenotic sites measured by EBUS and MDCT were near equal in all patients. Significant correlation was seen at all 212 sites (r=0.805, p   Conclusions:  This EBUS technique was successful in establishing accurate airway measurements for suitable airway stent sizes in interventional procedures, especially in cases with tracheobrochial malacia.
Abstract 2519: A small molecule that binds and inhibits the ETV1 transcription factor oncoprotein
Authors: Marius Pop, Nicolas Stransky, Colin Garvie, Jean-Philippe Theurillat, Timothy Lewis, Cheng Zhong, Elizabeth Culyba, Fallon Lin, Douglas Daniels, Raymond Pagliarini, Lucienne Ronco, Angela Koehler, Levi Garraway
Journal: Cancer Research (2014)

Abstract Members of the ETS transcription factor family have been implicated in several cancers, where they are often dysregulated by genomic derangement. ETS variant 1 (ETV1) is an ETS factor gene that undergoes chromosomal translocation in prostate cancers and Ewing's sarcomas, amplification in melanomas, and lineage dysregulation in gastrointestinal stromal tumors. Pharmacologic perturbation of ETV1 would be appealing in these cancers; however, oncogenic transcription factors are often deemed “undruggable” by conventional methods. Here, we used small-molecule microarray (SMM) screens to identify and characterize drug-like compounds that modulate the biological function of ETV1. We identified the 1,3,5-triazine small molecule BRD32048 as a top candidate ETV1 perturbagen. BRD32048 binds ETV1 directly, modulating both ETV1-mediated transcriptional activity and invasion of ETV1-driven cancer cells. Moreover, BRD32048 inhibits p300-dependent acetylation of ETV1, thereby promoting its degradation. These results point to a new avenue for pharmacological ETV1 inhibition and may inform a general means to discover small molecule perturbagens of transcription factor oncoproteins. Note: This abstract was not presented at the meeting. Citation Format: Marius Pop, Nicolas Stransky, Colin Garvie, Jean-Philippe Theurillat, Timothy Lewis, Cheng Zhong, Elizabeth Culyba, Fallon Lin, Douglas Daniels, Raymond Pagliarini, Lucienne Ronco, Angela Koehler, Levi Garraway. A small molecule that binds and inhibits the ETV1 transcription factor oncoprotein. [abstract]. In: Proceedings of the 105th Annual Meeting of the American Association for Cancer Research; 2014 Apr 5-9; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2014;74(19 Suppl):Abstract nr 2519. doi:10.1158/1538-7445.AM2014-2519
Abstract P043: Alcohol Consumption, Transferrin Saturation and Risk of All-Cause Mortality in The National Health and Nutrition Examination Surveys
Authors: Laurence O James, James N Kiage, Loren Lipworth, Uchechukwu K Sampson, Edmond K Kabagambe
Journal: Circulation (2015)

Background: Moderate alcohol consumers have a reduced risk for cardiovascular and all-cause mortality. Alcohol intake improves iron absorption and also has a profound effect on iron metabolism and thus could in part explain the observed inverse association between moderate alcohol intake and mortality. We sought to investigate whether moderate alcohol confers mortality benefits in part through improvement in iron status. Methods: Publicly available data from two consecutive National Health and Nutrition Examination Survey (NHANES) cycles (1999/2000 and 2001/2002) were obtained and linked to public data on all-cause mortality. Study participants were grouped as never, past, moderate (≤2 drinks/day for men, ≤ 1 drink/day for women) and heavy drinkers (&gt;2 drinks/day for men, &gt;1 drink/day for women). To assess the quality of alcohol data in NHANES, we tested whether self-reported alcohol consumption was associated with biomarkers of alcohol intake (HDL-C and γ-glutamyl transferase (GGT)). Cox-models, weighted using four-year sampling weights, were fitted to determine whether alcohol intake was associated with all-cause mortality. Measures of iron status, particularly serum ferritin, transferrin saturation, hemoglobin and free erythrocyte protoporphyrin were evaluated as potential mediators of the association between alcohol consumption and risk of all-cause mortality. Results: Among 7,532 men and women with complete data, 17% were never drinkers, 20% were past drinkers, 30% were moderate drinkers and 33% were heavy drinkers. We found an increase in HDL-C and GGT with increased alcohol intake, suggesting that self-reported alcohol intake is reliable in this population. In the weighted analysis, the hazard ratio (95% CI) for all-cause mortality among moderate alcohol users compared to never users was 0.56 (0.37-0.85), in models adjusted for age, race, smoking, statin use and history of diabetes, among other variables. Adjustment for transferrin saturation as a measure of iron status attenuated the benefit from moderate alcohol (HR = 0.69; 95% CI: 0.41-1.14), suggesting that moderate alcohol consumption may in part confer a benefit on mortality through improvement in iron status. These results warrant further evaluation in rigorous formal mediation analyses. Conclusions: Moderate alcohol consumption was associated with higher transferrin saturation and with reduced risk of mortality. Adjusting for iron status attenuated the association between moderate alcohol consumption and all-cause mortality suggesting that the effects of moderate alcohol on mortality may in part be via improvement in iron status.