GOLD SALTS IN THE TREATMENT OF RHEUMATOID ARTHRITIS; A STUDY OF 245 CASES
Authors: Russell L. Cecil, William H. Kammerer, Francois J. Deprume
Journal: Annals of Internal Medicine (1942)

Article1 May 1942GOLD SALTS IN THE TREATMENT OF RHEUMATOID ARTHRITIS; A STUDY OF 245 CASESRUSSELL L. CECIL, M.D., F.A.C.P., WILLIAM H. KAMMERER, M.D., FRANCOIS J. DEPRUME, M.D.RUSSELL L. CECIL, M.D., F.A.C.P.Search for more papers by this author, WILLIAM H. KAMMERER, M.D.Search for more papers by this author, FRANCOIS J. DEPRUME, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-16-5-811 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe use of gold salts in the treatment of rheumatoid arthritis has an interesting and rather unusual history. In 1927 Möllgaard1carried out some experiments with gold salts as to their effect on the tubercle bacillus. His results were so interesting that Secher2in Copenhagen undertook to treat tuberculosis in man with gold salts. Some of the French students of arthritis had formulated the theory that rheumatoid arthritis was a form of tuberculous joint disease. It was possibly this concept of the problem which led Forestier3in 1929 to try gold salts in the treatment of rheumatoid arthritis. About the...References*1. MÖLLGAARD H: Some of the principal questions in chemotherapy with special regard to heavy metals, Proc. Roy. Soc. Med., 1927, xx, 787. CrossrefGoogle Scholar2. SECHER K: Behandlung von Gelenkleiden mit Sanocrysin, Acta med. Scand., 1933, lxxix, 506-521; abstr. Deutsch, med. Wchnschr., 1933, lix, 90-91. Google Scholar3. FORESTIER J: L'aurotherapie dans les rheumatismes chroniques, Bull, et mém. Soc. méd. d. hôp. de Par., 1929, liii, 323. La chrysotherapie dans les rhumatismes chroniques, Bull, et mém. Soc. méd. d. hôp. de Par., 1929, xliv, 323. Google Scholar4. FELDT A: Chemotherapeutische Versuche mit Gold; die Wirkungsweise von Goldpraeparaten im infezierten Tiere, Klin. Wchnschr., 1927, vi, 1136. 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Mayo Clin., 1939, xiv, 117. Google Scholar8. SLOTDEVILLE GPM: The treatment of arthritis and rheumatism with gold, Lancet, 1934, i, 73. CrossrefGoogle Scholar9. FORESTIER J: Rheumatoid arthritis and its treatment by gold salts, Lancet, 1934, ii, 646. CrossrefGoogle Scholar10. HARTFALLGARLAND SJHG: Gold treatment of rheumatoid arthritis, Lancet, 1935, ii, 8. CrossrefGoogle Scholar11. FORESTIERCERTONCINY JP: La chrysothérapie prolongée dans les polyarthrites. Etude de cinquante cas, La revue du rhumatisme, 1936, iii, 485. Google Scholar12. HARTFALLGARLANDGOLDIE SJHGW: Gold treatment of arthritis, a review of 900 cases, Lancet, 1937, ii, 784, 838. CrossrefGoogle Scholar13. COPEMANTEGNER WSW: A review of gold therapy, Lancet, 1937, i, 554. CrossrefGoogle Scholar14. ELLMANLAWRENCE PJS: Gold therapy in rheumatoid arthritis: an assessment of its value with control experiments, Post-Grad. Med. Jr., 1938, xiv, 275. CrossrefGoogle Scholar15. ELLMANLAWRENCETHOROLD PJSGP: Gold therapy in rheumatoid arthritis, Brit. Med. Jr., 1940, ii, 312. Google Scholar16. KEYROSENFELDTJOFLAT JAHOE: Gold therapy in proliferative arthritis, Jr. Bone and Joint Surg., 1939, xxi, 339. Google Scholar17. SNYDERTRAEGERKELLY RGCTL: Gold therapy in proliferative arthritis, observation on 100 cases treated with gold sodium thiosulphate and aurocein, ANN. INT. MED., 1939, xii, 1672. Google Scholar18. KLINGSASHINSPANBOCK DHDJ: The mechanism of gold therapy in rheumatoid arthritis, Jr. Lab. and Clin. Med., 1939, xxiv, 1241. Google Scholar19. DAWSONHOBBY MHGL: Chemotherapy of experimental hemolytic streptococcal infections with gold salts, Jr. Pharmacol, and Exper. Therap., 1940, lxix, 359. Google Scholar20. SABINALBERTWARREN BJ: The curative effect of certain gold compounds on experimental proliferative chronic arthritis in mice, Jr. Bact, 1940, xl, 823. CrossrefGoogle Scholar21. ROTHBARDANGEVINECECIL SDMRL: The influence of gold sodium thiomalate (myochrysin) on the prevention of hemolytic streptococcus arthritis in rats, Jr. Pharmacol, and Exper. Therap., 1941, lxxii, 104. Google Scholar22. FREYBERGBLOCKLEVEY RHWDS: Metabolism, toxicity and manner of action of gold compounds used in the treatment of arthritis. 1. Human plasma and synovial fluid concentration and urinary excretion of gold during and following treatment with gold sodium thiomalate, gold sodium thiosulfate, and colloidal gold sulfide, Jr. Clin. Invest, 1941, xx, 401. Google Scholar23. HARTUNG EF: The excretion of gold following the administration of gold sodium thiomalate in rheumatoid arthritis, Jr. Lab. and Clin. Med., 1941, xxvi, 1750. Google Scholar24. FORESTIER J: Treatment of rheumatoid arthritis with gold salts injections, Lancet, 1932, i, 441. CrossrefGoogle Scholar25. FORESTIER J: Rheumatoid arthritis and treatment with gold salts, Jr. Lab. and Clin. Med., 1935, xx, 827. Google Scholar26. GASKING C: The influence of gold salts on the blood platelets in rheumatoid arthritis, Chronic Rheumatic Diseases (C. W. Buckley), 1938, H. K. Lewis & Co. Ltd., London, No. 4, p. 106. Google Scholar27. BOOTS R: President's address, American Rheumatism Association Meeting, Cleveland, Ohio, June 2, 1941. Google Scholar28. SABINWARREN AJ: The therapeutic effectiveness of a practically non-toxic new compound (Calcium Aurothiomalate) in experimental, proliferative, chronic arthritis of mice, Science, 1940, xcii, 535. CrossrefGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: New York, N. Y.*Received for publication November 24, 1941.From the Medical Service of the New York Hospital and the Department of Medicine of Cornell University Medical College, New York City. 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GRAFTON HERSPERGER, M.D., F.A.C.P.Rheumatoid Arthritis, Sanocrysin Treatment and Prognosis1Rheumatoid arthritis in the agedTHE USE OF BAL IN THE TREATMENT OF SKIN REACTIONS DUE TO GOLD THERAPY*M. M. MONTGOMERY, M.D.GOLD THERAPY IN EARLY RHEUMATOID ARTHRITIS*CHESTER H. ADAMS, M.D., RUSSELL L. CECIL, M.D., F.A.C.P.Rheumatoid Spondylitis: Questions and AnswersThe Problem of Dosage in the Administration of Gold Salts for Rheumatoid ArthritisAdvances in the Study and Treatment of Rheumatoid Arthritis as Reported in 1942 and Part of 1943 1 May 1942Volume 16, Issue 5Page: 811-827KeywordsBacillusHospital medicineMedical servicesRheumatoid arthritisSalts ePublished: 1 December 2008 Issue Published: 1 May 1942 Copyright & PermissionsCopyright, 1942, by The American College of PhysiciansPDF downloadLoading ...