tbuckley/cabot-search huggingface dataset:
Prevalence of adverse reactions to food in patients with gastrointestinal disease
Authors: S. C. Bischoff, A. Herrmann, M. P. Manns
Journal: Allergy (1996)

The role of allergic reactions in the pathogenesis of inflammatory bowel disease and irritable bowel syndrome has been disputed. This study aimed to determine the prevalence of adverse reactions to food in patients with gastrointestinal disease. A total of 375 adult patients of a gastroenterologic outpatient clinic were examined by history, skin tests, measurements of laboratory parameters, and intestinal provocation with food allergens by colonoscopy. Some 32% complained of adverse reactions to food as a cause of their abdominal symptoms. In 14.4%, the diagnosis of intestinal food allergy could be suspected according to several criteria such as elevated total IgE, specific IgE against food antigens, eosinophilia, responsiveness to cromoglycate, and clinical signs of atopic disease. In 3.2%, the diagnosis could be confirmed by endoscopic allergen provocation and/or elimination diet and rechallenge. In conclusion, the data suggest that allergic reactions to food antigens may be a causative factor in a subgroup of patients with inflammatory and functional gastrointestinal disease.
CASE OF EPITHELIOMA OF EYELIDS PLASTIC OPERATION, WITH EXHIBITION OF PATIENT.
Authors: HERBERT HARLAN
Journal: JAMA (1895)

2. Incision of the intermarginal space according to Jaksche-Arlt.3. Curved incision of the skin, 3 to 4 mm.above the ciliary border.Removal of a small strip of mus- cle along this incision.4. Grooving of the tarsus according to Streatfeild. 5. Passing sutures through the lower lip of the wound, the upper edge of the tarsus, and the skin of the upper lip.6. Detaching from the upper lip of the wound, with a straight pair of scissors, a strip of skin, 1.5 mm.broad and as long as the incision in the intermar- ginal space, and implanting it into the gaping and cleansed incision.Sutures may be used, but are not essential.-.7. Tying the skin-tarsus sutures, four or five in number.The threads may be cut short, or stretched and fastened to the skin above the brow by collodion (Panas) or strips of plaster (Born) if the free edge of the lid is not sufficiently everted.8. Dressing with bichlorid gauze, greased with a salve, or leaving the eye uncovered. 9. Cutting the sutures in from three to five days.Cleansing the eye every day, very gently so as not to disturb the implanted flap, or leaving the dressing undisturbed for a week.The flap in almost every case unites in its whole extent.This plan of operation is to be simplified or modi- fied, according to the conditions of the case.
Comparison of myocardial protection with nifedipine and potassium.
Authors: P G Magee, J T Flaherty, T J Bixler, D Glower, T J Gardner, B H Bukley, V L Gott
Journal: Circulation (1979)

Nifedipine, a slow-channel calcium blocker, is thought to provide useful myocardial protection during prolonged total ischemia and reperfusion. An isolated, isovolumic, feline heart model was used to asses the effectiveness of nifedipine in both cardioplegic (100 microgram/10 ml) and noncardioplegic (10 microgram/10 ml) doses for providing myocardial preservation during 90 minutes of hypothermic ischemic arrest and 45 minutes of normothermic reperfusion. Use of nifedipine was compared to hypothermia (27 degrees C) alone and to hypothermia with potassium cardioplegia. Ventricular function was assessed by recovery of isovolumic left ventricular developed pressure and dP/dt. Myocardial carbon dioxide tension (PCO2) and myocardial oxygen tension (PO2) were measured by mass spectrometry. Potassium cardioplegia and the higher dose of nifedipine resulted in immediate asystole. The rates of rise of PCO were greatest in the group receiving 10 microgram nifedipine and in the control group. The rates of rise in the two cardioplegic groups were significantly lower. Recovery of ventricular function was significantly lower with low-dose nifedipine than with potassium cardioplegia. Higher dose nifedipine resulted in a return of function, which was no different than with potassium cardioplegia. Morphologic protection was better with higher dose nifedipine and potassium cardioplegia than with either low-dose cardioplegia or hypothermia alone. These results demonstrate that nifedipine in a cardioplegic dose results in preservation of myocardial structure and function that is similar to that obtained with potassium cardioplegia. In lower noncardioplegic dose, nifedipine does not appear to offer additional protection compared to hypothermia alone. Whether persistent depression of ventricular contractility will limit nifedipine's clinical usefulness as a myocardial protection agent will require further study.
Dying from heart failure: lessons from palliative care
Authors: L. M E Gibbs, J. Addington-Hall, J S. R Gibbs
Journal: BMJ (1998)

Increasing interest and research into the care of the dying over the past 25 years have resulted in better symptom control, psychological support, and choice for people dying from cancer and their families.1 Little attention has been paid, however, to patients with other life threatening diseases, such as AIDS, neurological conditions, respiratory failure, and heart failure. Palliative care, with its emphasis on the care of patients whose prognosis is limited, on quality (not quantity) of life, and on a multidisciplinary approach, may benefit patients other than those with cancer. One such group is patients dying from heart failure.

Heart failure is the only major cardiovascular disease with increasing prevalence, incidence, and mortality. Incidence and prevalence both increase dramatically over the age of 75 years—up to 43.5 and 190 per 1000 population respectively.2 With age adjusted mortality from cardiovascular …
Promotion of liver regeneration by natural killer cells in a murine model is dependent on extracellular adenosine triphosphate phosphohydrolysis
Authors: Nadine Graubardt, René Fahrner, Markus Trochsler, Adrian Keogh, Karin Breu, Cynthia Furer, Deborah Stroka, Simon C. Robson, Emma Slack, Daniel Candinas, Guido Beldi
Journal: Hepatology (2012)

Nucleotides, such as adenosine triphosphate (ATP), are released by cellular injury, bind to purinergic receptors expressed on hepatic parenchymal and nonparenchymal cells, and modulate cellular crosstalk. Liver resection and resulting cellular stress initiate such purinergic signaling responses between hepatocytes and innate immune cells, which regulate and ultimately drive liver regeneration. We studied a murine model of partial hepatectomy using immunodeficient mice to determine the effects of natural killer (NK) cell-mediated purinergic signaling on liver regeneration. We noted first that liver NK cells undergo phenotypic changes post-partial hepatectomy (PH) in vivo , including increased cytotoxicity and more immature phenotype manifested by alterations in the expression of CD107a, CD27, CD11b, and CD16. Hepatocellular proliferation is significantly decreased in Rag2/common gamma-null mice (lacking T, B, and NK cells) when compared to wildtype and Rag1-null mice (lacking T and B cells but retaining NK cells). Extracellular ATP levels are elevated post-PH and NK cell cytotoxicity is substantively increased in vivo in response to hydrolysis of extracellular ATP levels by apyrase (soluble NTPDase). Moreover, liver regeneration is significantly increased by the scavenging of extracellular ATP in wildtype mice and in Rag2/common gamma-null mice after adoptive transfer of NK cells. Blockade of NKG2D-dependent interactions significantly decreased hepatocellular proliferation. In vitro , NK cell cytotoxicity is inhibited by extracellular ATP in a manner dependent on P2Y1, P2Y2, and P2X3 receptor activation. Conclusion : We propose that hepatic NK cells are activated and cytotoxic post-PH and support hepatocellular proliferation. NK cell cytotoxicity is, however, attenuated by hepatic release of extracellular ATP by way of the activation of specific P2 receptors. Clearance of extracellular ATP elevates NK cell cytotoxicity and boosts liver regeneration.
How music fills our emotions and helps us keep time
Authors: Patricia V. Agostino, Guy Peryer, Warren H. Meck
Journal: Behavioral and Brain Sciences (2008)

Abstract Whether and how music is involved in evoking emotions is a matter of considerable debate. In the target article, Juslin &amp; Västfjäll (J&amp;V) argue that music induces a wide range of both basic and complex emotions that are shared with other stimuli. If such a link exists, it would provide a common basis for considering the interactions among music, emotion, timing, and time perception.
Natural History of the Eosinophilia-Myalgia Syndrome
Authors: Randall C. Culpepper, Ronald G. Williams, Philip J. Mease, Thomas D. Koepsell, John M. Kobayashi
Journal: Annals of Internal Medicine (1991)

To describe the natural history and disease progression of the eosinophilia-myalgia syndrome and to assess the therapeutic effects of orally administered steroids on the disorder as of October 1990.Case-series analysis. A cohort of 45 patients with the eosinophilia-myalgia syndrome was followed prospectively by periodic telephone interviews and medical examinations for an average of 14 months after onset of illness.Washington state.The cases of 47 patients were reported to the Washington State Department of Health from 1 July to 12 December 1989. Two patients were unavailable for follow-up, and the remaining 45 completed the study.Patients were predominantly non-Hispanic white women (87%) with an average age of 49 years. Symptoms typically progressed from early onset of myalgia and fatigue to later development of neurologic and scleroderma-like skin changes. Six (13%) patients recovered completely within 2 to 5 months of symptom onset. After 14 months of illness, over half of the patients who initially presented with myalgia, fatigue, or scleroderma-like skin changes remained symptomatic. The average severity of each major symptom was measured using interviews and patient self-reports and has improved subjectively by at least 40%. Statistical analyses showed no significant difference in long-term symptom duration or severity between patients treated and those not treated with prednisone.The eosinophilia-myalgia syndrome is a long-term illness characterized by progressive improvement during the first 25 weeks after symptom onset, followed by a protracted phase of symptom resolution. We could not show a clear-cut benefit of prednisone in reducing the long-term severity or duration of the disease.
Modulation of sodium-hydrogen exchange activity in cardiac myocytes during acidosis and realkalinisation: effects on calcium, pHi, and cell shortening
Authors: C. A Ward, M. P Moffat
Journal: Cardiovascular Research (1995)

Objective: The aim was to examine the effects of the Na+/H+ exchange inhibitor methylisobutylamiloride (MIA) as well as protein kinase C, a putative regulator of Na+/H+ exchange, on intracellular calcium, intracellular pH, and unloaded cell shortening in isolated guinea pig cardiac myocytes subjected to lactic acid induced acidosis followed by realkalinisation. Methods: Calcium transient amplitude and cell shortening were measured simultaneously in single isolated myocytes loaded with fura2-AM. Intracellular pH was measured in cells loaded with BCECF-AM. Results: Exposure of cells to 5 min of lactate (20 mM) acidosis (pH 6.8) caused an increase in calcium transient amplitude and a decrease in cell shortening and intracellular pH. During realkalinisation (pH 7.3), the calcium transient gradually decreased while intracellular pH became more alkaline than pre-acidosis values. The cells underwent transient hypercontractility as evidenced by a marked increase in systolic cell shortening and a decrease in diastolic cell length. Inhibition of sodium/hydrogen exchange with MIA (1 μM) caused a significant attenuation of the increase in calcium transient amplitude during acidosis and further depressed cell shortening as well as intracellular pH. In addition, MIA significantly attenuated hypercontractility and abolished cell contracture upon realkalinisation. In contrast, phorbol 12-myristate 13-acetate (10−12 M) exerted no effects on the response to acidosis; however, this treatment exacerbated cell hypercontractility and reduced functional recovery upon realkalinisation. Conclusions: Inhibition of Na+/H+ exchange activity during acidosis/realkalinisation enhances recovery of cell function.
Journal of hematology &amp; oncology: A journal open to all
Authors: Delong Liu
Journal: Journal of Hematology & Oncology (2008)

Journal of Hematology & Oncology aims not to specialize, rather to broaden and provide a platform for information exchange for all studies related to blood and cancer. It aims to include, not to exclude, all studies from basic research, translational research, case reports, and clinical trials. This journal allows the authors to keep the copyright so they can freely use and disseminate their articles as they please. All articles published in this journal are also archived in PubMed, PubMed Central, and other repositories. Therefore, this journal aims not to restrict, rather to make all published articles free and open to all.
In Defense of Case Reports and Case Series
Authors: Jan P. Vandenbroucke
Journal: Annals of Internal Medicine (2001)

Case reports and case series have their own role in the progress of medical science. They permit discovery of new diseases and unexpected effects (adverse or beneficial) as well as the study of mechanisms, and they play an important role in medical education. Case reports and series have a high sensitivity for detecting novelty and therefore remain one of the cornerstones of medical progress; they provide many new ideas in medicine. At the same time, good case reporting demands a clear focus to make explicit to the audience why a particular observation is important in the context of existing knowledge.
Implications of Potential Positive Correlation Between Autologous Tumor-Cell-Killing Activity and Prognosis in Lung Cancer
Authors: J. R. Ortaldo, R. H. Wiltrout
Journal: JNCI Journal of the National Cancer Institute (1990)

of circulating IGF-1 and completely block tumor growth.The new antiestrogens, should they become available in the clinic, may facilitate the survival of node-positive patients and be useful to maintain the control of tumor growth in advanced breast cancer.Regrettably, the physiological side-effects that could be associated with the long-term treatment of node negative disease (i.e., atherosclerosis and osteoporosis) may preclude an application in these patients.The concept of a dual ER-mediated control mechanism for regulating breast tumor growth will provide new opportunities to block endocrine-dependent growth completely.The possibility that tamoxifen and other less estrogenic antiestrogens may retard the growth of some ER-negative tumors heralds the broader application of an effective anticancer agent.Indeed, the beneficial therapeutic effect of tamoxifen in patients with a wide range of malignancies (i.e., melanoma, pancreatic carcinoma), cited in numerous anecdotal reports, may be a consequence of reduced serum IGF-1 levels.Pharmacological methods to lower markedly or to eliminate serum IGF-1 levels may prove to be a valuable therapeutic strategy to control a variety of malignancies.Perhaps phase I clinical studies with pure antiestrogens will demonstrate antitumor effects in cancers other than breast cancer via an IGF-1 mediated mechanism.
THE ANALYSIS OF GASTRIC JUICE FOR "FREE ACIDITY (ORGANIC AND INORGANIC)"
Authors: Roger S. Hubbard
Journal: JAMA (1924)

In the analysis of gastric juice, the amount of "hydrochloric acid," of "total acid," and sometimes of "free acid— organic and inorganic" which it contains are determined. In these determinations a sample of the gastric juice is titrated with alkali to three different hydrogen ion concentrations, shown by the end-points with the indicators dimethylamino-azobenzene (Töpfer's reagent), phenolphthalein and alizarin, respectively. For titrating the "free acidity, organic and inorganic," Hawk<sup>1</sup>gives the following directions included under the discussion of Töpfer's method of gastric analysis: "Add 3 drops of alizarin sulphonate solution to the contents of vessel B (a beaker or porcelain dish containing 10 c.c. of strained gastric juice) and titrate with N/10 sodium hydroxide until a<i>violet</i>color is produced. In this titration the red color... must be entirely replaced by a<i>distinct violet color</i>." The end-point described is the color change which alizarin shows at the neutral point
Development of Behavioral Tests for the Assessment of Neurologic Effects of lead in Sheep
Authors: Thomas L. Carson, Gary A. Van Gelder, George G. Karas, William B. Buck
Journal: Environmental Health Perspectives (1974)

Reports of neurologic impairment of children following recovery from acute lead encephalopathy have raised questions concerning the effects of chronic low-level lead exposure on the central nervous system. Behavioral toxicologic techniques have been employed to assess the effects of lead on the central nervous system in sheep. Mature sheep receiving daily doses of 100 mg lead/kg showed a significant decrease in performance on an auditory signal detection task. Daily oral doses of 120 and 230 mg lead/sheep for 27 weeks did not alter the performance of mature sheep on a fixed-interval schedule of reinforcement behavioral task. Prenatal exposure to maternal blood lead levels of 16 or 34 μg/100 ml during gestation and postnatal daily ingestion of 16, 8, 4, or 2 mg lead/kg did not alter performance of lambs on a closed-field maze task. Slowed learning was demonstrated in lambs prenatally exposed to maternal blood lead levels of 34 μg/100 ml during gestation when tested on nonspatial, two-choice visual discrimination problems at 10–15 months of age.
Supraceliac Aortic Occlusion Demonstrated by Radionuclide Aortography
Authors: B E SHELLEY, IVAN VUJIC, STEPHEN I. SCHABEL, LEONIE GORDON
Journal: Clinical Nuclear Medicine (1981)

A case of supraceliac aortic occlusion diagnosed by a radionuclide angiogram and confirmed by contrast aortography is presented. The place of radionuclide angiograms in the evaluation of suspected aortic occlusions is discussed.
METABOLISM OF SALT-RETAINING HORMONE BY SURVIVING LIVER SLICES 1
Authors: Jerome J. Chart, Edgar S. Gordon, Phyllis Helmer, Marjorie Le Sher
Journal: Journal of Clinical Investigation (1956)

Evidence has been produced in this and other laboratories that the impaired capacity to excrete sodium which characterizes a number of clinical states involving edema, ascites and anasarca, is mediated, in part at least, through a humoral fac- tor emanating, in all probability, from the adrenal cortex (1-8).It now appears almost certain, on the basis of available evidence, that this substance, generally referred to in this paper as salt-retaining hormone or electrocortin, is aldosterone or a de- rivative of it (9, 10).Since quantitative measurements indicate that this sodium-retaining hormone is excreted in the urine in abnormally high concentration under these pathological conditions, curiosity concerning the underlying mechanism naturally arises.Two hypothetical possibilities are suggested: 1. Over- production of salt-retaining hormone by the adrenal cortex initiates an abnormal anti-natri- uretic and antidiuretic response. 2. Physiological inactivation or metabolism of the hormone by ex- tra-adrenal tissues is impaired with a resulting rise in blood, tissue and urine concentrations of "active" hormone.However, it is possible that accumulation of salt-retaining hormone, whatever its cause, bears no cause and effect relationship to fluid retention and other related manifestations of disease.In view of the recent evidence by Conn (11, 12) and Mader and Iseri (13) consideration must be given to the first of these possibilities."Primary aldosteronism," a new syndrome described by these investigators, is characterized by hyperna-
Deafness after topical neomycin.
Authors: K W Murphy
Journal: BMJ (1970)

hernias repaired.On examination the lump was found to be closely associated with and deep to the umbilicus, of a cystic consistency, but did not give a cough impulse nor was it reducible- into the peritoneal cavity.At operation, the swelling was found to com- municate with the peritoneal cavity.It contained an appendix, the tip of which was chronically inflamed and adherent to the under surface of the umbilical skin.Routine appendicectomy was carried out and no other abnormality was noted.f--.4.. Photograph of specimen with umbilicus and attached appendix.The specimen (Fig. ) was sectioned and microscopic appearances were that of a mild interstitial inflammation of the appendix.Postoperatively he did well and was dis- charged home two weeks after his operation.At follow-up one month later he was well.
Radiology: An Illustrated History
Authors: John M. Clark
Journal: JAMA (1992)

Professor Eisenberg has amassed a collection of photographs depicting the history of radiology. Wired-up gadgets, faces of pioneers, and primitive early glass x-ray tubes spraying unshielded radiation over fluoroscopists and patients alike give a shocking reality to this history text. Even if the reader doesn't understand technical language, the world's most astonishing scientific discovery and the medical advancements that followed can be appreciated through 979 illustrations. When Roentgen published a photograph depicting the bones in his wife's hand, he touched off a chain reaction of research and discovery culminating in more than two dozen medical specialties referred to as "radiology." Rather than providing an overall chronology, Eisenberg treats each subspecialty as a separate history, sometimes leaving the reader wishing for a comparative time line. He takes the history of the field from the days of Isaac Newton to television-era developments like angiography and streptokinase. The format of the 9 ×
Genome-Wide Association Study of Prognosis in Advanced Non–Small Cell Lung Cancer Patients Receiving Platinum-Based Chemotherapy
Authors: Lingmin Hu, Chen Wu, Xueying Zhao, Rebecca Heist, Li Su, Yang Zhao, Baohui Han, Songyu Cao, Minjie Chu, Juncheng Dai, Jing Dong, Yongqian Shu, Lin Xu, Yijiang Chen, Yi Wang, Feng Lu, Yue Jiang, Dianke Yu, Hongyan Chen, Wen Tan, Hongxia Ma, Jiaping Chen, Guangfu Jin, Tangchun Wu, Daru Lu, David C. Christiani, Dongxin Lin, Zhibin Hu, Hongbing Shen
Journal: Clinical Cancer Research (2012)

Genetic variation may influence chemotherapy response and overall survival in cancer patients.We conducted a genome-wide scan in 535 advanced-stage non-small cell lung cancer (NSCLC) patients from two independent cohorts (307 from Nanjing and 228 from Beijing). A replication was carried out on an independent cohort of 340 patients from Southeastern China followed by a second validation on 409 patients from the Massachusetts General Hospital (Boston, MA).Consistent associations with NSCLC survival were identified for five single-nucleotide polymorphisms (SNP) in Chinese populations with P values ranging from 3.63 × 10(-5) to 4.19 × 10(-7) in the additive genetic model. The minor allele of three SNPs (rs7629386 at 3p22.1, rs969088 at 5p14.1, and rs3850370 at 14q24.3) were associated with worse NSCLC survival while 2 (rs41997 at 7q31.31 and rs12000445 at 9p21.3) were associated with better NSCLC survival. In addition, rs7629386 at 3p22.1 (CTNNB1) and rs3850370 at 14q24.3 (SNW1-ALKBH1-NRXN3) were further replicated in the Caucasian population.In this three-stage genome-wide association studies, we identified five SNPs as markers for survival of advanced-stage NSCLC patients treated with first-line platinum-based chemotherapy in Chinese Han populations. Two of these SNPs, rs7629386 and rs3850370, could also be markers for survival among Caucasian patients.