Treatment of Angina Pectoris With a Tissue Vasodilator Extract-Preliminary Report
Authors: Joseph B. Wolffe, Donald Findlay, Edward Dessen
Journal: Annals of Internal Medicine (1931)

Article1 November 1931Treatment of Angina Pectoris With a Tissue Vasodilator Extract-Preliminary ReportJOSEPH B. WOLFFE, M.D., DONALD FINDLAY, Ph.D., EDWARD DESSEN, M.D.JOSEPH B. WOLFFE, M.D.Search for more papers by this author, DONALD FINDLAY, Ph.D.Search for more papers by this author, EDWARD DESSEN, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-5-5-625 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptIn 1926 E. K. Frey and H. Kraut1 found a substance in the urine which they demonstrated to have vasodilator properties, and which they believed to be a circulation hormone (Kreislaufhormon). In 1929 Frey2 operated on a patient who had a pancreatic cyst and found that the cystic fluid was rich in this particular hormone. They have since studied this product extensively and have come to the following conclusions:1. The hormone is present in the blood and is excreted in the urine.2. The hormone is present in the blood mainly in an inactivated form and excreted in the...References1 FREYKRAUT EKH: [Substance stimulating heart activity excreted by the kidney], Ztschr. f. Biol., 1926, lxxxiv, 321-334. Google Scholar2 FREY EK: Kreislaufhormon und innere Sekretion, München. med. Wchnschr., 1929, lxxvi, 1951-1952. Google Scholar3 Foreign Letter, Jr. Am. Med. Assoc., 1930, xcv, 676. Google Scholar4 GLEYKISTHINIOS PN: Recherches sur la substance hypotensive du pancreas, Presse méd., 1929, xxxvii, 1279-1282. Google Scholar5 VAQUEZGIROUXKISTHINIOS HRN: De l'action de certains extraits pan creatiques dans le traitement de l'angine poitrine, Presse méd., 1929, xxvii, 1277-1279. Google Scholar6 SCHWARTZMAN JS: Muscle extract in treatment of angina pectoris and intermittent claudication. Brit. Med. Jr., 1930, i, 855-856. CrossrefGoogle Scholar7 SCHWARTZMAN MS: Muscle extract in treatment of angina pectoris and intermittent claudication. Brit. Med. Jr., 1930, i, 855-856. CrossrefGoogle Scholar8 FAHRENKAMPSCHNEIDER KH: Vergleichende Untersuchungen mit einen als Hormocardial bezeichneten Herzhormonpräparat und einen neuratigen Muskelextrakt, Med. Klin., 1930, xxvi, 48-50. Google Scholar9 DRURYSZENT-GYORGI AM: Physiological activity of adenine compounds with special reference to their action on the mammalian heart. Jr. Physiol., 1929, lxviii, 213-237. CrossrefGoogle Scholar10 GLEYKISTHINIOS PN: Recherches sur la substance hypotensive du pancreas, Presse méd., 1929, xxxvii, 1279-1282. Google Scholar11 SCHAUDER H: Zur Behandlung des intermittierenden Hinkens, München, med. Wchnschr., 1930, lxxvii, 196-205. Google Scholar12 LEVINEERNSTENEJACOBSON SAACBM: Use of epinephrin as diagnostic test for angina pectoris with observation on electrocardiographic changes following injections of epinephrin into normal subjects and into patients with angina pectoris, Arch. Int. Med., 1930, xlv, 191-200. CrossrefGoogle Scholar13 LOEWI : Sajous, Analytical Encyclopedia of Medicine, 10 Edition, Vol. 7, Page 268. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Philadelphia, Pa.*Submitted for publication May 21, 1931.†Read before the Section on Medicine, College of Physicians, Philadelphia, November, 1930. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byBibliographyTHE ROLE OF ARTERIAL DISEASES IN CLINICAL MEDICINEThe role of insulin-free, histamine-free pancreatic tissue extract in the treatment of peripheral arterial diseaseFurther Observations on Use of Insulin-Free Pan-Creatic Tissue Extract as an AID in Cystoscopic Treatment of Impacted Ureteral Calculi and Spastic Occlusion of UreterDeproteinated pancreatic extract (depropanex)Pancreatic extract (enzyme-free) in the treatment of diabetic and arteriosclerotic gangreneDie Klinik der Coronarerkrankungen 1 November 1931Volume 5, Issue 5Page: 625-642KeywordsAnginaBloodHormonesUrineVasodilators ePublished: 1 December 2008 Issue Published: 1 November 1931 PDF downloadLoading ...