tbuckley/cabot-search huggingface dataset:
HPV-Associated Head and Neck Cancer: Unique Features of Epidemiology and Clinical Management
Authors: Jessica H. Maxwell, Jennifer R. Grandis, Robert L. Ferris
Journal: Annual Review of Medicine (2015)

Human papillomavirus (HPV) is a recently identified causative agent for a subset of head and neck cancers, primarily in the oropharynx, and is largely responsible for the rising worldwide incidence of oropharyngeal cancer (OPC). Patients with HPV-positive OPC have distinct risk factor profiles and generally have a better prognosis than patients with traditional, HPV-negative, head and neck cancer. Concurrent chemotherapy and radiation is a widely accepted primary treatment modality for many patients with HPV-positive OPC. However, recent advances in surgical modalities, including transoral laser and robotic surgery, have led to the reemergence of primary surgical treatment for HPV-positive patients. Clinical trials are under way to determine optimal treatment strategies for the growing subset of patients with HPV-positive OPC. Similarly, identifying those patients with HPV-positive cancer who are at risk for recurrence and poor survival is critical in order to tailor individual treatment regimens and avoid potential undertreatment.
Image-Aided Estimate of Tumor Burden in Hodgkin’s Disease: Evidence of Its Primary Prognostic Importance
Authors: Paolo G. Gobbi, Maria L. Ghirardelli, Marco Solcia, Giuseppe Di Giulio, Francesco Merli, Luisa Tavecchia, Raffaella Bertè, Ottavio Davini, Alessandro Levis, Chiara Broglia, Gabriella Carnevale Maffè, Fiorella Ilariucci, Roberto Dore, Edoardo Ascari
Journal: Journal of Clinical Oncology (2001)

PURPOSE: To explore a more direct method for evaluating tumor burden (TB) in Hodgkin’s disease (HD) and to verify its prognostic importance. PATIENTS AND METHODS: The volume of TB at diagnosis was directly and retrospectively measured in 121 HD patients through images of the lesions recorded by computed tomographic (CT) scan of the thorax, abdomen, and pelvis for all deep sites of involvement and many superficial ones, and by ultrasonography (US) for the remaining superficial lesions. RESULTS: The TB, which was obtained from the sum of the volumes of all the lesions measured on CT scans and US and normalized to body-surface area (relative TB [rTB]), showed a median value of 102.6 cm 3 /m 2 (range, 2.2 to 582.8). At multivariate analysis for prognostic value, rTB was the parameter that statistically correlated best with time to treatment failure (P = 2.2 × 10 -6 ), followed by erythrocyte sedimentation rate (ESR) (P = .0003), and serum fibrinogen (P = .0112). The prognostic discrimination allowed by rTB alone proved to be clearly superior to that obtained with the score of the International Prognostic Factor Project. The rTB was found to be correlated with many clinical staging parameters (bulky disease, number of involved lymph node regions, serum lactate dehydrogenase, ESR, hemoglobin, Karnofsky index), but its predictability from these variables was low (R 2 = .668). CONCLUSION: Relative TB is emerging as a strong prognostic factor in HD, more powerful than and largely independent of those hitherto known and used. Further studies are needed to confirm these results and exploit their clinical value, particularly the relationship among rTB, drug doses, and response.
Comparison of survival endpoints in glioblastoma patients receiving or not receiving enzyme-inducing anticonvulsants in NCCTG Trials
Authors: K. A. Jaeckle, K. Ballman, J. Uhm, J. O'Fallon, P. Schomberg, B. Scheithauer, C. Giannini, P. J. Flynn, J. Buckner
Journal: Journal of Clinical Oncology (2004)

1525 Background: P450 enzyme-inducing anticonvulsants (EIAC) reduce serum levels of chemotherapeutic agents metabolized by CYP3A4 and CYP2A6. Although decreased toxicity of chemotherapy (e.g, CPT-11) has been observed in EIAC vs. non-EIAC patients, effects on survival are less clear. Methods: Univariable and multivariable analyses were performed on our last 3 completed prospective Phase II/III NCCTG trials (937252, 987251, and N0074; N=642) of newly-dx glioblastoma (GBM), to assess relationships between AC/EIAC treatment and overall- (OS) and progression-free survival (PFS). Baseline seizure history was available on 1 of the 3 studies (N=93). OS was measured from surgery until death or last follow-up; PFS from time of study enrollment. Results: There were 463 AC-treated and 447 EIAC-treated patients. AC use was univariately positively associated with steroid use (p=0.003), age (p=0.005) and MMSE (p=0.028); extent of resection distributions also differed between patients on AC and those not (p=0.0001). OS- and PFS were independently associated with AC use (HR=0.75, p =0.0029, and HR=0.80, p=0.0023 respectively) in a multivariable Cox model, adjusting for age, steroid use, extent of resection, and MMSE. EIAC use (N=447) was also independently associated with OS and PFS (HR=0.75, p=0.0029 and HR=0.81, p=0.024, respectively). For patients on ACs, there was no difference in median OS between those with (9.2 mo) and without (13 mo) a history of seizures (p=0.12). Conclusions: We expected to find that patients on AC and EIAC might have shorter survivals, as a result of reduction in chemotherapy serum levels due to CYP3A4/2A6 induction. However, we paradoxically observed longer OS and PFS in patients receiving AC and EIAC. We also postulated that the need of AC/EIAC for treatment of seizures (a positive prognostic variable in prior Phase III trials) might select for biologically more indolent disease, but seizure history did not correlate with improved OS/PFS in a subset of our patients on ACs. These data suggest that AC and EIAC status at study entry should be considered as stratification variables in prospective clinical trials. No significant financial relationships to disclose.
Abstract 4217: Prediction of Acute Coronary Syndrome Using Computed Tomography
Authors: Sadako Motoyama, Masayoshi Sarai, Hiroto Harigaya, Tomonori Hara, Kaori Inoue, Hiroyuki Naruse, Junnichi Ishi, Nathan D Wong, Hitoshi Hishida, Yukio Ozaki, Jagat Narula
Journal: Circulation (2008)

Background: Computed tomographic (CT) characteristics of culprit lesions in acute coronary syndrome (ACS) include positive remodeling (PR) and non-calcified plaques with low attenuation (NCP&lt;30HU). Such imaging characteristics have almost always been described by evaluating the lesions that have already resulted in ACS. In a CT study, we identified the characteristics of atherosclerotic lesions which were associated with subsequent development of acute coronary syndrome (ACS). Methods: 1067 patients who underwent CT angiography were followed for at least 12 months (mean = 28.0±10.6 months; range=12–50 months). The plaque characteristics of lesions resulting in ACS were compared with those not resulting in ACS. Results: Twenty-six patients developed ACS after CT examination. Of these, 15 patients could be evaluated the culprit lesions. Of 1067 patients, 72 demonstrated plaque characteristics suggestive of vulnerable plaque; 45 plaques demonstrated both PR and NCP&lt;30HU (probably vulnerable) ; 27 had either PR or NCP&lt;30HU (possibly vulnerable). Eight-hundred twenty patients did not demonstrate either of these characteristics (probably stable). Ten of 45 who had both PR and NCP&lt;30HU developed ACS (22.2%), 1 had either PR or NCP&lt;30HU (3.33%). Four of 820 patients with no PR or NCP&lt;30HU (0.49%) developed ACS. PR and/or NCP&lt;30HU was detected in 61 patients without subsequent development of ACS. Cox regression analysis was performed using 9 variables including age, gender, hypertension, hyperlipidemia, diabetes mellitus, obesity, smoking, prior myocardial infarction, and the presence of probably or possibly vulnerable plaques; the presence of probably or possibly vulnerable plaques was significant independent predictor of ACS (Hazard Ratio 14.38, p&lt;0.001). There was significant increase in occurrence of ACS in patients with probably or possibly vulnerable plaques than patients without these plaque characteristics (15.3% vs 0.4%, loglank test p&lt;0.001) Conclusions: The CT-based atherosclerotic plaque characteristics responsible for subsequent ACS include NCP&lt;30HU and positive remodeling; the presence of such plaques strongly predict development of ACS in patients with coronary artery disease.
Circulating level of hepatocyte growth factor predicts incidence of type 2 diabetes mellitus: The Multi-Ethnic Study of Atherosclerosis (MESA)
Authors: Michael P Bancks, Suzette J Bielinski, Paul A Decker, Naomi Q Hanson, Nicholas B Larson, Hugues Sicotte, Christina L Wassel, James S Pankow
Journal: Metabolism (2015)
The Lack, Magill and Bain Anaesthetic Breathing Systems: A Direct Comparison in Spontaneously-Breathing Anaesthetized Adults
Authors: David Humphrey
Journal: Journal of the Royal Society of Medicine (1982)

The performances of the Lack (Mapleson A), Magill (Mapleson A) and Bain (Mapleson D) anaesthetic breathing systems were compared in each of 20 anaesthetized adult patients breathing spontaneously with fresh gas flows of 70 ml kg-1 min-1. In every patient the Lack system caused the least rebreathing, as seen by the lowest inspired and end-expired CO2 tensions using capnography. The Magill caused more rebreathing than the Lack though less than the Bain. Comparative fresh gas flows for each system at the point where rebreathing started to occur were examined in 10 further patients. The Lack system required approximately 51 ml kg-1 min-1, the Magill 72 ml kg-1 min-1 while the Bain required 153 ml kg-1 min-1. Of the three systems the Lack is concluded to be the most efficient and economical system for spontaneous respiration in adults, with the additional advantages of convenient access to the exhaust valve, easy scavenging and low expiratory resistance. In addition, it also offers many useful advantages over the circle absorber system.
Enhancement of Antitumor Effects of 1-Hexylcarbamoyl-5-fluorouracil Combined with Hyperthermia on Ehrlich Ascites Tumor in Vivo and Nakahara-Fukuoka Sarcoma Cell in Vitro
Authors: Masanori Tsumura, Koji Yoshiga, Kazuaki Takada
Journal: Cancer Research (1988)

1-Hexylcarbamoyl-5-fluorouracil (HCFU) was found to be hydrolyzed to 5-fluorouracil (5-FU) depending on temperature. In this study, the antitumor effects of HCFU with hyperthermia were studied on Ehrlich ascites in tumor-bearing CD-1 mice and Nakahara-Fukuoka sarcoma cells. Concurrently, the change of 5-FU concentration in the Ehrlich tumor was also observed. In vivo , Ehrlich cells were transplanted in the foot pads of mice. HCFU (80 mg/kg) and 5-FU (40 mg/kg) (same molarity) were administered orally on the 3rd, 6th, and 9th days after transplantation and simultaneously hyperthermia (43.5°C, 45 min) was induced. The antitumor effect was evaluated by the tumor volume. On the 9th day after transplantation, HCFU (150 mg/kg) and 5-FU (75 mg/kg) were administered with or without hyperthermia (43.5°C, 45 min) and the tumor tissues were taken for 5-FU concentration analysis. In addition, Nakahara-Fukuoka sarcoma cells were incubated (42°C various times) with our without HCFU and 5-FU (both 1 × 10-4 m) in vitro . The cytotoxicity was evaluated by colony forming assay. The most effective condition was found to be the combination of HCFU with hyperthermia in vitro and in vivo . The highest 5-FU concentration was observed by the treatment of HCFU combined with hyperthermia in vivo . Hence, HCFU could be clinically useful in thermochemotherapy.
Abstract 3248: Left Ventricular Endocardial Asynchrony in Left Bundle Branch Block is Similar Between Simultaneous Biventricular Pacing and Single Site Left Ventricular Pacing
Authors: Marc Strik, Arne van Hunnik, Marion Kuiper, Anniek Lampert, Caroline J van Deursen, Leonard Rademakers, Angelo Auricchio, Frits W Prinzen
Journal: Circulation (2009)
CCL9 Induced by TGFβ Signaling in Myeloid Cells Enhances Tumor Cell Survival in the Premetastatic Organ
Authors: Hangyi H. Yan, Jian Jiang, Yanli Pang, B.R. Achyut, Michael Lizardo, Xinhua Liang, Kent Hunter, Chand Khanna, Christine Hollander, Li Yang
Journal: Cancer Research (2015)

Tumor cell survival in the hostile distant organ is a rate-limiting step in cancer metastasis. Bone marrow-derived myeloid cells can form a premetastatic niche and provide a tumor-promoting microenvironment. However, it is unclear whether these myeloid cells in the premetastatic site have any direct effect on tumor cell survival. Here, we report that chemokine CCL9 was highly induced in Gr-1(+)CD11b(+) immature myeloid cells and in premetastatic lung in tumor-bearing mice. Knockdown of CCL9 in myeloid cells decreased tumor cell survival and metastasis. Importantly, CCL9 overexpression in myeloid cells lacking TGFβ signaling rescued the tumor metastasis defect observed in mice with myeloid-specific Tgfbr2 deletion. The expression level of CCL23, the human orthologue for CCL9, in peripheral blood mononuclear cells correlated with progression and survival of cancer patients. Our study demonstrates that CCL9 could serve as a good candidate for anti-metastasis treatment by targeting the rate-limiting step of cancer cell survival. In addition, targeting CCL9 may avoid the adverse effects of TGFβ-targeted therapy.
Bronchial vagal tone and responsiveness to histamine, exercise and bronchodilators in adult patients with cystic fibrosis
Authors: E H van Haren, J W Lammers, J Festen, C L van Herwaarden
Journal: European Respiratory Journal (1992)

Atopy and bronchial responsiveness to histamine, exercise and bronchodilators were investigated in 18 adult patients with cystic fibrosis (CF). Reversibility of airflow limitation was measured after ipratropium bromide and terbutaline, and histamine and exercise provocation tests were performed. Histamine hyperresponsiveness was observed in 10 out of 18 patients and was not confined to those with severe airway obstruction. The positive histamine responders showed significantly better bronchodilatation after terbutaline, when compared to negative histamine responders. Histamine responsiveness was not related to atopy or exercise responsiveness. Exercise challenge caused bronchodilatation without bronchoconstriction in all patients. The exercise-induced bronchodilatation correlated with bronchodilatation after ipratropium bromide. It is proposed that an increased vagal tone may lead to an increased resting bronchomotor tone which can be reduced by ipratropium bromide and by exercise in adult patients with cystic fibrosis.
Abstract 3169: Increase in Risk of Death in Early Months Following Hospitalization for Heart Failure: Observations from the CHARM Program
Authors: Scott D Solomon, Joanna Marro, Stuart Pocock, Hicham Skali, John J McMurray, Christopher Granger, Salim Yusuf, Karl Swedberg, Eric L Michelson, James B Young, Marc A Pfeffer
Journal: Circulation (2006)

Background: Patients with chronic heart failure (HF) are at increased risk for both fatal and non-fatal major adverse cardiovascular events. We assessed the influence of non-fatal hospitalization f...
Abstract 4202: Deciphering the effects of GNA13 mutations in B-cell lymphomas
Authors: Morgan L. O'Hayre, Irina Kufareva, Jose P. Vaqué, Miguel A. Piris, J. Silvio Gutkind
Journal: Cancer Research (2014)

Abstract G-proteins and their cognate G-protein coupled receptors (GPCRs) are critical signal transduction molecules that regulate cell survival, proliferation, motility and differentiation. The aberrant expression or function of these molecules has been linked to growth, progression and metastasis of various cancers. Recent genome-wide sequencing efforts have unveiled numerous previously uncharacterized mutations in G-proteins and GPCRs, which could have significant implications to cancer initiation and progression. Of interest, recent analyses have demonstrated that there are frequent mutations in GNA13 in Burkitt's lymphoma and Diffuse Large B cell lymphomas (DLBCL) that are highly statistically significant over background cancer gene mutation rate, and occur in ∼10-13% of patients with these lymphomas. Mutations in the downstream target of G13, RhoA, are also present in several Burkitt's lymphoma tumors, highlighting that mutations in this G13-RhoA pathway may be key to the oncogenic potential of these B cell lymphomas. Although G13 activity has previously been linked cellular transformation and metastatic potential of epithelial cancers, our data suggests that the mutations in GNA13 in these B cell lymphomas are mostly inhibitory in nature. Thus, we have functionally characterized several mutations in GNA13 and RHOA found in Burkitt's lymphoma and DLBCL. Citation Format: Morgan L. O'Hayre, Irina Kufareva, Jose P. Vaqué, Miguel A. Piris, J. Silvio Gutkind. Deciphering the effects of GNA13 mutations in B-cell lymphomas. [abstract]. In: Proceedings of the 105th Annual Meeting of the American Association for Cancer Research; 2014 Apr 5-9; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2014;74(19 Suppl):Abstract nr 4202. doi:10.1158/1538-7445.AM2014-4202
Personality science, resilience, and posttraumatic growth
Authors: Eranda Jayawickreme, Marie J. C. Forgeard, Laura E. R. Blackie
Journal: Behavioral and Brain Sciences (2015)

Abstract PASTOR represents an innovative development in the study of resilience. This commentary highlights how PASTOR can help both clarify critical questions in and benefit from engaging with new research in personality science on behavioral flexibility across situations in addition to stability over time, and also clarify the relationship between resilience and posttraumatic growth.
Restriction to the Cell Nucleus of Virus-Induced Host RNA's in a Rat Kidney Tumor Induced by Polyoma Virus 2
Authors: Ruth Whisler Shearer
Journal: JNCI Journal of the National Cancer Institute (1978)

Journal Article Restriction to the Cell Nucleus of Virus-Induced Host RNA's in a Rat Kidney Tumor Induced by Polyoma Virus Get access Ruth Whisler Shearer, Ph.D. Ruth Whisler Shearer, Ph.D. Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 60, Issue 6, June 1978, Pages 1383–1385, https://doi.org/10.1093/jnci/60.6.1383 Published: 01 June 1978 Article history Received: 19 August 1977 Accepted: 08 January 1978 Published: 01 June 1978
Prognostic Value of a High On-Clopidogrel Treatment Platelet Reactivity in Bivalirudin Versus Abciximab Treated Non–ST-Segment Elevation Myocardial Infarction Patients
Authors: Dirk Sibbing, Isabell Bernlochner, Stefanie Schulz, Steffen Massberg, Albert Schömig, Julinda Mehilli, Adnan Kastrati
Journal: Journal of the American College of Cardiology (2012)
Unusual locations of tuberculosis: Three cases report
Authors: Houda Gharsalli, Saloua Azzabi, Mohamed Ali Baccar, Jamel ElGoul, Besma Ourari-Dhahri, Jihéne Ben Ammar, Leila El Gharbi, Hichem Aouina, Hend Bouacha
Journal: European Respiratory Journal (2011)

Introduction:  Tuberculosis (TB) can involve any organ but unusual location concern specially immunodeficient patients.We report three unusual TB locations in immuocompetent patients.   Case report:  The first patient is an immunocompetent woman admitted for pulmonary nodular lesions,pleural effusion and bilateral ovarian cysts. The eleved CA125 level suggested ovarian metastatic carcinoma. Pleural biopsy confirmed TB and presumed  ovarian TB . Outcome was favorable with antituberculosis therapy (ATT) with disappearance of ovarian cysts. The second case interested an immunocompetent woman who presented simultaneous occurrence of  multifocal cutaneous TB  with pseudotumoral pulmonary TB. The cutaneous TB was revealed by squamous plaques and erythema in face, abdomen and breast. The diagnosis was confirmed by biopsy of the skin. Favorable outcome was observed with ATT.  The third case is about an immunocompetent woman who presented decrease in visual acuity. The lesions observed by funduscopy suggered  TB chorioretinitis . Tuberculin skin test was positive. The diagnostic was confirmed by fluorescein angiography. After starting tuberculosis treatment the ocular symptoms regressed
Prognostic importance of restaging gallium scans following induction chemotherapy for advanced Hodgkin's disease.
Authors: S C King, R J Reiman, L R Prosnitz
Journal: Journal of Clinical Oncology (1994)

This study was intended to assess the ability of restaging gallium scanning to distinguish between patients with residual radiographic abnormalities who still have active Hodgkin's disease (HD) and those who are truly complete responders. Early identification of the former patients might increase the success of secondary salvage therapy.The charts of all patients with advanced HD treated at Duke University Medical Center during the years 1983 to 1991 who underwent gallium scanning were reviewed. Thirty-three patients were identified who had gallium scans performed as part of restaging following induction combination chemotherapy; no patient had other signs or symptoms of active or progressive HD.Thirteen of 33 patients had positive restaging gallium scans; 20 patients had negative scans. The 4-year actuarial relapse-free survival (RFS) rate was 75% for patients with negative restaging gallium scans compared with 8% for those with positive restaging scans (P < .001). The 4-year actuarial overall survival (OS) rate was 100% for those with negative scans compared with 51% for gallium-positive patients (P = .001). Twenty-four patients had residual chest x-ray or computed tomographic scan abnormalities. Calculated negative and positive predictive values for gallium scanning are 92% and 90%, respectively, compared with values of 48% and 83% for computed tomographic scanning.Restaging gallium scans separate complete responders from induction failures with a high degree of accuracy. Gallium scanning is clearly superior to computed tomography in this regard. Patients with advanced HD who have positive restaging gallium scans after induction chemotherapy should be classified as induction failures and are highly unlikely to be cured with involved-field low-dose radiotherapy.
Use of DSM-III axis IV in clinical practice: rating etiologically significant stressors
Authors: Skodol Ae, Shrout Pe
Journal: American Journal of Psychiatry (1989)

This study compared the etiologically significant stressors listed on DSM-III axis IV (severity of psychosocial stressors) with life events elicited by the Psychiatric Epidemiology Research Interview (PERI). Multiaxial evaluations of a diagnostically heterogeneous group of 362 patients were made, and all patients were subsequently administered the PERI by interviewers blind to the clinical assessments. The results indicated that axis IV functions well as a shorthand method for identifying the more severe psychosocial stressors. However, the DSM-III requirement that the stressor be important in the development or exacerbation of the current disorder resulted in discrepancies between the axis IV and PERI assessments.
Abstract 1529: Grp94 Overexpression Counteracts Ischemia-Induced Activation of Caspase-12 and Protects Cells After Transplantation in the Infarcted Myocardium.
Authors: Maurizio Vitadello, Marta Crocco, Elena Tarricone, Francesco Zigrino, Sandro Sponga, Gino Gerosa, Luisa Gorza
Journal: Circulation (2006)

Extensive apoptosis of grafted cells represents a major hindrance towards a successful cell therapy. We then compared in vitro and in vivo the extent of anti-apoptotic protection induced by differe...