THE GALACTOSE AND UROBILINOGEN TESTS IN THE DIFFERENTIAL DIAGNOSIS OF OBSTRUCTIVE AND INTRAHEPATIC JAUNDICE
Authors: David H. Rosenberg
Journal: Annals of Internal Medicine (1934)

Article1 July 1934THE GALACTOSE AND UROBILINOGEN TESTS IN THE DIFFERENTIAL DIAGNOSIS OF OBSTRUCTIVE AND INTRAHEPATIC JAUNDICEDAVID H. ROSENBERG, M.D.DAVID H. ROSENBERG, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-8-1-60 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe enigma which may confront the internist in the differential diagnosis between mechanically obstructive and intrahepatic (toxic or infectious) jaundice, occurring particularly in individuals beyond the age of 35, is indeed a familiar though often disconcerting situation. Bauer1has often emphasized his contention that the galactose tolerance test provides an exact differentiation between these two types of jaundice, for his results were consistently negative in the obstructive form and distinctly positive in the intrahepatic form, unless the latter was of a very mild nature. The observations of other German investigators tended in the main to corroborate these findings. Davies,2although...Bibliography1. BAUER R: (a) Über die Assimilation von Galaktose und Milchzucker beim Gesunden und Kranken, Wien. med. Wchnschr., 1906, lvi, 20-23. (b) Weitere Untersuchungen über alimentäre Galaktosurie, ibid., 2537-2545. (c) Über alimentäre Galaktosurie bei Ikterus, Deutsch. med. Wchnschr., 1908, xxxiv, 1505-1507. (d) Ikterus und Leberfunktion, Wien. Arch. f. inn. Med., 1923, vi, 9-36. (e) Unsere Kenntnisse über Leberfunktion und ihre Verwertung für die Klinik, Wien. klin. Wchnschr., 1932, xlv, 1577-1581. Google Scholar2. DAVIES DT: Diagnosis of hepatic disorders, Lancet, 1927, i, 380-384. CrossrefGoogle Scholar3. SHAYSCHLOSSBELL HEMMA: Metabolism of galactose; considerations underlying use of galactose in tests of function of liver, Arch. Int. Med., 1931, xlvii, 391-402. CrossrefGoogle Scholar4. SHAYSCHLOSSRODIS HEMI: Galactose tolerance test in differential diagnosis of jaundice, ibid., 650-659. Google Scholar5. SHAYSCHLOSS HE: Painless jaundice; its differential diagnosis by galactose tolerance test, Jr. Am. Med. Assoc., 1932, xcviii, 1433-1436. CrossrefGoogle Scholar6. BANKSSPRAGUESNELL BMPHAM: Clinical evaluation of galactose tolerance test, Jr. Am. Med. Assoc., 1933, c, 1987-1993. CrossrefGoogle Scholar7. MÜLLER F: Über den normalen Koth des Fleischfressers, Ztschr. f. Biol., 1884, xx, 327-377. Untersuchungen über Ikterus, Ztschr. f. klin. Med., 1887, xii, 45-113. Chronische Leberentzündung, Verhandl. d. kong. f. Inn. Med., 1892, xi, 118. Google Scholar8. BECK A: Über die Entstehung des Urobilins, Wien. klin. Wchnschr., 1895, viii, 323. Google Scholar9. WILBURADDIS RLT: Urobilin: its clinical significance, Arch. Int. Med., 1914, xiii, 235-286. CrossrefGoogle Scholar10. ELMANMCMASTER RPD: Urobilin physiology and pathology; quantitative determination of urobilin, Jr. Exper. Med., 1925, xli, 503-512. CrossrefGoogle Scholar11. MCMASTERELMAN PDR: Studies on urobilin physiology and pathology; derivation of urobilin, ibid., 513-534. Google Scholar12. _____: Studies on urobilin physiology and pathology; absorption of pigment of biliary derivation from intestine, ibid., 719-738. Google Scholar13. ELMANMCMASTER RPD: Urobilin physiology and pathology; urobilin and damaged liver, ibid., 1925, xlii, 99-122. Google Scholar14. _____: Urobilin physiology and pathology; relation between urobilin and conditions involving increased red cell destruction, ibid., 619-640. Google Scholar15. MCMASTERELMAN PDR: Studies on urobilin physiology and pathology; relation of biliary infections to genesis and excretion of urobilin, ibid., 1926, xliii, 753-783. Google Scholar16. WALLACEDIAMOND GBJS: Significance of urobilogen in urine as a test for liver function, Arch. Int. Med., 1925, xxxv, 698-725. CrossrefGoogle Scholar17. _____: Further observations on urobilogen test for liver function, Warthin Ann., 1927, 407-413. Google Scholar18. DIAMOND JS: Pathology and diagnosis in diseases of liver and biliary tract, Med. Clin. N. Am., 1927, x, 1009-1031. Google Scholar19. SCOTT LD: Colorimetric method for estimation of urobilinogen in urine and feces, Jr. Lab. and Clin. Med., 1933, xviii, 399-405. Google Scholar20. BAUER R: Die Ehrlich'sche Aldehydreaktion in Harn and Stuhl, Zentralbl. f. inn. Med., 1905, xxvi, 833-842. Google Scholar21. SALMON UJ: Excretion of bile pigments in experimental obstructive jaundice, Surg., Gynec. and Obst., 1933, lvi, 621-627. Google Scholar22. GERHARDT D: Über Urobilin, Ztschr. f. klin. Med., 1897, xxxii, 302 Google Scholar23. FISCHLER : Physiologie und Pathologie der Leber, 1906. Google Scholar24. TUMENPIERSOL HJGM: Value of alimentary galactosurie in diagnosis of jaundice, ANN. INT. MED., 1933, vii, 311-329. Google Scholar25. PIERSOLBOCKUSSHAY GMHLH: Diagnostic value of duodenal drainage in gall-stone disease; with special reference to significance of so-called bilirubin calcium pigment, Am. Jr. Med. Sci., 1928, clxxv, 84-96. CrossrefGoogle Scholar26. BOCKUSSHAYWILLARDPESSEL HLHJHJF: Comparison of biliary drainage and cholecystography in gall-stone diagnosis, with special reference to bile microscopy, Jr. Am. Med. Assoc., 1931, xcvi, 311-317. CrossrefGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Chicago, Illinois*Presented before the Section on Gastroenterology and Proctology at the Cleveland Session of the American Medical Association, June 14, 1934.From the Departments of Medicine and Physiology, Northwestern University Medical School, and from the Medical Service of the Cook County Hospital. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byIntravenous galactose tolerance test using a modified techniqueDie Krankheiten der Leber und der GallenwegeA comparison of three urobilinogen tests in trie urine, (the watson, Sparkman, and Wallace and diamond methods) in jaundice and diseases of the liverThe Value Of A Combined Study Of The Newer Laboratory Test In The Differential Diagnosis Of Toxic And Obstructive Jaundice Including Blood Phosphatase, Cholesterol Partition, Galactose Tolerance And Glucose ToleranceDie Krankheiten der Leber und der GallenwegeDie Krankheiten der Leber und der GallenwegeThe galactose tolerance and urobilinogen tests in the differential diagnosis of painless jaundiceThe differentiation of surgical and medical groups of jaundiceThe weltmann test in diseases of the liver 1 July 1934Volume 8, Issue 1Page: 60-71KeywordsHospital medicineMedical services ePublished: 1 December 2008 Issue Published: 1 July 1934 PDF downloadLoading ...