tbuckley/cabot-search huggingface dataset:
Health Problem in Berlin
Authors: P. G. Horsburgh, H. A. Raeburn
Journal: BMJ (1946)

As a political experiment in international co-operation the government of a city such as Berlin by four Allied Powers with different outlooks and different aims-is unique.The importance of the success of such an experiment is widely realized, and it was thought that an account of the problems facing and the work done by the Public Health Section of the British Military Government would not be without interest.These problems will be described as they presented themselves to the Public Health Section.The situation was chaotic on arrival-in spite of the existence of a German administration, normally very efficient, struggling to resuscitate itself.It must be appreciated that it was always very difficult to obtain in- formation as to exactly what was occurring.Anyone who saw the city last July and sees it to-day cannot but be struck by the general improvement of the health conditions. General SituationThe story of Berlin during the year 1945 is well known.Until the Russian advance early in the year the city's Health Department had, in spite of the heavy bombing, managed to keep the health services functioning.In the early months of the year the city became more or less an operational area and dis- integration started, culminating in complete chaos with the battle for Berlin and the city's capture on May 2. There then followed a period of Russian occupation, when military and political considerations were paramount and the health of the population was of secondary interest.The British troops arrived on July 4, and British military government began to function on July 12.Berlin, a city with a pre-war population of 4,306,500, is governed by a " Magistrat," which includes a Health Depart- ment headed by a Medical Officer of Health.The city is sub- divided into 20 districts, or Bezirks, each with its municipal authority and health department.Unlike the Metropolitan Boroughs of London, the Bezirk is not an independent authority, but comes completely under the control of the city's Magistrat.The actual German administration was left unchanged by the Allied Powers, but each Power became responsible for a section of the city*-comprising a number of Bezirks, as shown on the accompanying map (see p. 425).Control over the German Magistrat is exercised by a joint Allied body known as the Kommandatura.Policy is deter- mined at meetings attended by the Commandants (the general officers commanding the four Allied contingents in Berlin).Technical matters are dealt with by committees of the Kom- mandatura, comprising a representative of each Allied Power.Meetings are held weekly, or oftener if necessary, when problems are discussed, and if agreement is reached appropriate instructions are sent-in the case of the Commandants' meeting, to the Magistrat of the city, or, on technical matters, by the committee concerned to the appropriate department.The four Allied Powers provide a chairman for the main meeting and committee meetings in rotation, each chairman holding office * The French took over their *ector on Aug. 12, 1945.Previously this sector came under British administration.
Observations on liver regeneration after right hepatic lobectomy
Authors: L. H. Blumgart, K. G. Leach, S. J. Karran
Journal: Gut (1971)

Restoration of liver mass has been studied in five patients after right hepatic lobectomy. The operation effects an approximate 50% resection of liver substance. Postmortem observations, measurements of the weight of liver resected at operation, and the study of serial radioisotopic liver scans suggest that liver regeneration in man is initiated very soon after partial hepatectomy and is well advanced within 10 days of operation.
Absence of Increased Tc-99m Polyclonal Human Immunoglobulin (HIG) Joint Uptake in a Patient With Systemic Lupus Erythematosus Presenting With Polyarticular Joint Complaints
Authors: F Jacobs, R A. Dierckx, E Vranken, F De Vos, C Van de Wiele
Journal: Clinical Nuclear Medicine (2005)

Several studies have shown that Tc-99m HIG (polyclonal human immunoglobulin) scintigraphy allows for identification of inflamed joints. However, no data are available in patients with systemic lupus erythematosus (SLE). A patient with a definite diagnosis of SLE presented with symmetric polyarticular complaints and was injected with 550 MBq (14.8 mCi) of Tc-99m labeled HIG. Whole-body images as well as detailed images of the hands and feet were acquired 4 hours after injection and showed no significant tracer uptake in any joint.
Smoking and Alcohol Abuse: A Comparison of Their Economic Consequences
Authors: Bryan R. Luce, Stuart O. Schweitzer
Journal: New England Journal of Medicine (1978)

Smoking and alcohol abuse are two chronic problems whose health consequences have enormous economic implications. Berry has estimated the economic consequences of alcohol abuse elsewhere,1 , 2 and we have recently done a similar analysis of smoking.3 In this article we consider the health and economic consequences of tobacco and alcohol together, contrasting and comparing their current costs to our society.We have taken Berry's 1971 estimates of alcohol abuse, analyzed them in terms of 1976 dollars, and compared them to the costs of smoking (also adjusted to 1976). By comparing such costs (whether economic or disability costs), public-health administrators can make . . .
A6.3 Immunisation with Recombinant Autocitrullinated<i>Porphyromonas Gingivalis</i>Peptidylarginine Deiminase Induces Autoimmunity to Enolase and Arthritis in DBA/1 Mice
Authors: Anne-Marie Quirke, Dany Perocheau, Anna Montgomery, Patrick J Venables
Journal: Annals of the Rheumatic Diseases (2013)

<h3>Background and Objectives</h3> Rheumatoid arthritis (RA) is characterised by the presence of anti-citrullinated peptide antibodies (ACPA) years before disease onset. Increasing molecular and epidemiological evidence has linked periodontitis (PD) to RA. <i>Porphyromonas gingivalis</i> is unique amongst periodontal pathogens in possessing a citrullinating enzyme, peptidylarginine deiminase (PPAD) with the potential to generate citrullinated antigens driving the autoimmune response in RA. We have examined the immune response to several peptides/proteins of significance to RA in DBA/1 mice immunised with recombinant PPAD. <h3>Materials and Methods</h3> Twelve week old DBA/1 mice were immunised with one of two emulsions: 1) recombinant PPAD in complete Freund's adjuvant (CFA) or 2) an inactive PPAD mutant (C351A) in CFA. Clinical score and paw swelling of mice (indicative of arthritis) recorded for ten days post onset. Antibody responses to PPAD and C351A, and a number of immunodominant ACPA target peptides: anti-citrullinated a-enolase peptide-1 (CEP1), vimentin (cVim), fibrinogen (cFib) and their uncitrullinated forms (REP-1, vim and fib) were examined in mouse serum using Enzyme-linked Immunosorbant assays (ELISAs). The Mann-Whitney U test was used to calculate p-values for differences between the sera groups for each antigen. <h3>Results</h3> By day 30 post immunisation, 20% of mice immunised with PPAD had developed arthritis-like swelling in their paws. There was no significant difference between the antibody response to PPAD and the antibody response to C351A in any of the mice tested. There was a significantly raised antibody response (p &lt; 0.05) to both CEP1 and REP1 (mean 0.263; OD<sup>450</sup>) in the mice immunised with PPAD compared to the mice immunised with C351A (CEP1, mean 0.074 (OD<sup>450</sup>) and REP1 mean 0.150 (OD<sup>450</sup>). Antibody responses to cFib and Fib were similar in all mice, as were antibody responses to cVim and Vim. <h3>Conclusions</h3> The paw swelling and raised immune response to the immunodominant enolase peptide, both citrullinated (CEP1) and uncitrullinated (REP1), in mice immunised with autocitrullinated PPAD shows that PPAD induces arthritis and autoimmunity to enolase. This demonstrates that an active citrullinating PPAD can break tolerance to a major RA autoantigen and provides further molecular evidence linking <i>P. gingivalis</i> infection to RA.
TIME TRENDS IN CARDIOVASCULAR RISK FACTOR MANAGEMENT IN CORONARY PATIENTS IN EUROPE: RESULTS FROM THREE EUROASPIRE SURVEYS 1999-2013
Authors: Kornelia Kotseva, Dirk De Bacquer, Catriona Jennings, Viveca Gyberg, Guy De Backer, Lars Ryden, David Wood
Journal: Journal of the American College of Cardiology (2014)
Intracranial pressure monitoring and liver transplantation for fulminant hepatic failure
Authors: Steven D. Lidofsky, Nathan M. Bass, Marie C. Prager, Denna E. Washington, Alexandra E. Read, Teresa L. Wright, Nancy L. Ascher, John P. Roberts, Bruce F. Scharschmidt, John R. Lake
Journal: Hepatology (1992)

Cerebral edema and intracranial hypertension, commonly present in fulminant hepatic failure, may lead to brainstem herniation and limit the survival of comatose patients awaiting liver transplantation before a donor organ becomes available. Also, they are likely responsible for postoperative neurological morbidity and mortality. Although intracranial pressure monitoring has been proposed to aid clinical decision making in this setting, its use in the prevention of brainstem herniation preoperatively, in the selection of patients for liver transplantation who have the potential for neurological recovery and in the maintenance of cerebral perfusion during liver transplantation has not been examined in detail. To address these issues, we established a protocol for intracranial pressure monitoring in comatose patients with fulminant hepatic failure as part of their preoperative and intraoperative management. Twenty adults and three children underwent intracranial pressure monitoring. Ten patients required preoperative medical therapy with mannitol, barbiturates or both for a rise in intracranial pressure above 25 mm Hg. Four patients had a sustained lowering of intracranial pressure, three of whom survived hospitalization. Six patients had intracranial hypertension refractory to medical management, were removed from a waiting list for a donor organ and died with brainstem herniation. Of the remaining 17 patients, 3 died of other causes while awaiting a donor organ, 2 recovered spontaneously without neurological sequelae and 12 underwent liver transplantation. All but one patient undergoing liver transplantation had transient intraoperative intracranial hypertension develop, requiring medical treatment. The 12 patients who had transplants recovered neurologically and were discharged from the hospital. Survival after liver transplantation was 92% (range of follow–up = 3 to 37 mo), and the overall survival of the 23 monitored patients was 56.5%. The major complication of intracranial pressure monitoring was intracranial hemorrhage, which occurred in five patients and contributed to two patient deaths. Intracranial pressure monitoring represents a potentially important tool in the preoperative and intraoperative management of comatose patients with fulminant hepatic failure and warrants further study. (Hepatology 1992;16:1-7.)
Take it like a man: pseudodrugs for man flu
Authors: Ike Iheanacho
Journal: BMJ (2011)

Listen to the male sufferers and you’d think that they were dying. However, they do tend to look better than they swear they feel. The resulting scepticism that these men provoke may well trigger them into overenergetic sniffing, coughing, or nose blowing, and an even more florid recounting of the terrible lethargy, discomfort, and infirmity that onlookers can’t even begin to appreciate.⇑

Sooner or later the victims, as they have by then come to regard themselves, take to their beds. Thankfully, though, their symptoms typically resolve quickly with rest …
Skewing the T-Cell Repertoire by Combined DNA Vaccination, Host Conditioning, and Adoptive Transfer
Authors: Annelies Jorritsma, Adriaan D. Bins, Ton N.M. Schumacher, John B.A.G. Haanen
Journal: Cancer Research (2008)

Approaches for T-cell-based immunotherapy that have shown substantial effects in clinical trials are generally based on the adoptive transfer of high numbers of antigen-specific cells, and the success of these approaches is thought to rely on the high magnitude of the tumor-specific T-cell responses that are induced. In this study, we aimed to develop strategies that also yield a T-cell repertoire that is highly skewed toward tumor recognition but do not rely on ex vivo generation of tumor-specific T cells. To this end, the tumor-specific T-cell repertoire was first expanded by DNA vaccination and then infused into irradiated recipients. Subsequent vaccination of the recipient mice with the same antigen resulted in peak CD8(+) T-cell responses of approximately 50%. These high T-cell responses required the presence of antigen-experienced tumor-specific T cells within the graft because only mice that received cells of previously vaccinated donor mice developed effective responses. Tumor-bearing mice treated with this combined therapy showed a significant delay in tumor outgrowth, compared with mice treated by irradiation or vaccination alone. Furthermore, this antitumor effect was accompanied by an increased accumulation of activated and antigen-specific T cells within the tumor. In summary, the combination of DNA vaccination with host conditioning and adoptive transfer generates a marked, but transient, skewing of the T-cell repertoire toward tumor recognition. This strategy does not require ex vivo expansion of cells to generate effective antitumor immunity and may therefore easily be translated to clinical application.
Transcriptional Regulation of Enhancers Active in Protodomains of the Developing Cerebral Cortex
Authors: Kartik Pattabiraman, Olga Golonzhka, Susan Lindtner, Alex S. Nord, Leila Taher, Renee Hoch, Shanni N. Silberberg, Dongji Zhang, Bin Chen, HongKui Zeng, Len A. Pennacchio, Luis Puelles, Axel Visel, John L.R. Rubenstein
Journal: Neuron (2014)
Human Blastomycosis from Dog Bites
Authors: John W. Hiemenz, Philip J. Coccari, Abe M. Macher
Journal: Annals of Internal Medicine (1983)

Letters and Corrections1 June 1983Human Blastomycosis from Dog BitesJOHN W. HIEMENZ, M.D., PHILIP J. COCCARI, D.V.M., ABE M. MACHER, M.D.JOHN W. HIEMENZ, M.D.Search for more papers by this author, PHILIP J. COCCARI, D.V.M.Search for more papers by this author, ABE M. MACHER, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-98-6-1030_2 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: Gnann and associates (1) state that "no instance of zoonotic transmission of blastomycosis has previously been documented"; however, a case has been reported (2). Dr. Jaspers reports a case of human cutaneous blastomycosis after a dog bite. The human cutaneous (finger) tissue and the autopsied animal lung tissue both grew Blastomyces dermatitidis. Dr. Jaspers suggested that transmission of Blastomyces from animal to humans occurs via infected sputum. The case we describe below supports Dr. Jaspers' theory.A 2½-year-old female cocker spaniel had been treated for anterior uveitis in the right eye for 1 month. After a week...References1. GNANN J, BRESSLER G, BODET C, and AVENT C. Human blastomycosis after a dog bite. Ann Intern Med. 1983;98:48-9. LinkGoogle Scholar2. JASPERS R. Transmission of blastomycosis from animals to man. J Am Vet Med Assoc. 1974;164:8. MedlineGoogle Scholar3. LARSON D, ECKMAN M, ALBER R, and GODSCHMIDT V. Primary cutaneous (inoculation) blastomycosis: an occupational hazard to pathologists. Am J Clin Pathol. 1983;79:253-5. CrossrefMedlineGoogle Scholar4. SCOTT M. Cutaneous blastomycosis: report of a case following a dog bite. Northwest Med. 1955;54:255-7. MedlineGoogle Scholar1. GNANN J, BRESSLER G, BODET C, and AVENT C. Human blastomycosis after a dog bite. Ann Intern Med. 1983;98:48-9. LinkGoogle Scholar2. LARSON D, ECKMAN M, ABLER R, and GOLDSCHMIDT V. Primary cutaneous (inoculation) blastomycosis: an occupational hazard to pathologists. Am J Clin Pathol. 1983;79:253-5. CrossrefMedlineGoogle Scholar3. DISMUKES W, STAMM A, and GRAYBILL J. Treatment of systemic mycoses with ketoconazole: emphasis on toxicity and clinical response in 52 patients. Ann Intern Med. 1983;98:13-20. LinkGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: JOHN W. HIEMENZ, M.D.; PHILIP J. COCCARI, D.V.M.; ABE M. MACHER, M.D. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byVeterinariansVeterinariansVeterinariansVeterinary SurgeonsThe Epidemiology of Blastomycosis 1 June 1983Volume 98, Issue 6Page: 1030-1031KeywordsBlastomycesBlastomycosisLungsSputumUveitis ePublished: 1 December 2008 Issue Published: 1 June 1983 PDF downloadLoading ...
ABCA Transporter Gene Expression and Poor Outcome in Epithelial Ovarian Cancer
Authors: Ellen L. Hedditch, Bo Gao, Amanda J. Russell, Yi Lu, Catherine Emmanuel, Jonathan Beesley, Sharon E. Johnatty, Xiaoqing Chen, Paul Harnett, Joshy George, Rebekka T. Williams, Claudia Flemming, Diether Lambrechts, Evelyn Despierre, Sandrina Lambrechts, Ignace Vergote, Beth Karlan, Jenny Lester, Sandra Orsulic, Christine Walsh, Peter Fasching, Matthias W. Beckmann, Arif B. Ekici, Alexander Hein, Keitaro Matsuo, Satoyo Hosono, Toru Nakanishi, Yasushi Yatabe, Tanja Pejovic, Yukie Bean, Florian Heitz, Philipp Harter, Andreas du Bois, Ira Schwaab, Estrid Hogdall, Susan K. Kjaer, Allan Jensen, Claus Hogdall, Lene Lundvall, Svend Aage Engelholm, Bob Brown, James Flanagan, Michelle D Metcalf, Nadeem Siddiqui, Thomas Sellers, Brooke Fridley, Julie Cunningham, Joellen Schildkraut, Ed Iversen, Rachel P. Weber, Andrew Berchuck, Ellen Goode, David D. Bowtell, Georgia Chenevix-Trench, Anna deFazio, Murray D. Norris, Stuart MacGregor, Michelle Haber, Michelle J. Henderson
Journal: JNCI Journal of the National Cancer Institute (2014)

BackgroundATP-binding cassette (ABC) transporters play various roles in cancer biology and drug resistance, but their association with outcomes in serous epithelial ovarian cancer (EOC) is unknown.
Killer T Cells
Authors: Christopher S. Henney
Journal: New England Journal of Medicine (1974)

Investigators concerned with the problem of homograft rejection have derived particular satisfaction from recent demonstrations of the direct cytotoxic action of immune lymphoid cells, because their studies have long demanded the existence of a complement-independent cytodestructive process. Although it is now clear that several cell types can function as effector cells in in vitro cytotoxic systems, particular attention has been directed towards the thymus-derived (T) lymphocyte. The reasons for this focus are twofold: it has been possible to ascribe physiologic importance to the T-cell's lytic action, and to show that in the absence of antibody only T lymphocytes can function . . .
Electroconvulsive Therapy and Memory Loss
Authors: Anne B. Donahue
Journal: JAMA (2007)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Empfindung und Intentionalität (Schmerz, Hypnose und Umwelt)
Authors: G. Kienle
Journal: Psychotherapy and Psychosomatics (1966)

Research Articles| February 12 2010 Empfindung und Intentionalität (Schmerz, Hypnose und Umwelt) Subject Area: Psychiatry and Psychology G. Kienle G. Kienle Frankfurt a.M., Neurologische Klinik (Direktor Prof. Dr. P. Duus) des Krankenhauses Nordwest, Frankfurt/a.M. Search for other works by this author on: This Site PubMed Google Scholar Psychother Psychosom (1966) 14 (5-6): 398–406. https://doi.org/10.1159/000285863 Article history Published Online: February 12 2010 Content Tools Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Facebook Twitter LinkedIn Email Tools Icon Tools Get Permissions Cite Icon Cite Search Site Citation G. Kienle; Empfindung und Intentionalität (Schmerz, Hypnose und Umwelt). Psychother Psychosom 31 December 1966; 14 (5-6): 398–406. https://doi.org/10.1159/000285863 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAll JournalsPsychotherapy and Psychosomatics Search Advanced Search This content is only available via PDF. 1966Copyright / Drug Dosage / DisclaimerCopyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher.Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. Article PDF first page preview Close Modal You do not currently have access to this content.
A common epitope is shared by activated signal transducer and activator of transcription-5 (STAT5) and the phosphorylated erythropoietin receptor: implications for the docking model of STAT activation
Authors: Dwayne L. Barber, Bryan K. Beattie, Jacqueline M. Mason, Melody H.-H. Nguyen, Monique Yoakim, Benjamin G. Neel, Alan D. D'Andrea, David A. Frank
Journal: Blood (2001)