VITAMIN D POISONING: A REPORT OF TWO CASES
Authors: Paget Davies
Journal: Annals of Internal Medicine (1960)

Case Reports1 December 1960VITAMIN D POISONING: A REPORT OF TWO CASESPAGET DAVIES, M.B., M.R.C.P.PAGET DAVIES, M.B., M.R.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-53-6-1250 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptIn 1942, two of the earliest cases in the literature of vitamin D poisoning in adults were described by Tumulty and Howard.1 Since that time many reports have appeared and the clinical picture has been well described, particularly by Howard and Meyer in 19482 and by Chaplin et al. in 1951.3Despite its toxicity, vitamin D continues to be used with little or no justification in conditions such as sarcoidosis, asthma, psoriasis, and rheumatoid arthritis, and often results in poisoning. In addition, the availability of highly concentrated preparations of vitamin D has led to intoxication resulting from self-medication.4In the...Bibliography1. TumultyHoward PAJE: Irradiated ergosterol poisoning—report of two cases, J. A. M. A. 119: 233, 1942. CrossrefGoogle Scholar2. HowardMeyer JERJ: Intoxication with vitamin D, J. Clin. Endocrinol. 8: 895, 1948. CrossrefMedlineGoogle Scholar3. ChaplinClarkRopes HLSMW: Vitamin D intoxication, Am. J. M. Sc. 221: 369, 1951. CrossrefMedlineGoogle Scholar4. Freedman P: Renal colic and persistent hypercalciuria following self-administration of vitamin D, Lancet 1: 668, 1957. CrossrefGoogle Scholar5. AlbrightReifenstein FEC: Parathyroid glands and metabolic bone disease, 1948, Ballière, Tindall and Cox, London, p. 95. Google Scholar6. ReedStruckSteck CJHCIE: Vitamin D: chemistry, physiology, pharmacology, pathology, experimental and clinical investigations, 1939, University of Chicago Press, Chicago, pp. 165 and 205. Google Scholar7. BadenochFourman JP: Osteomalacia in steatorrhoea, Quart. J. Med. 23: 165, 1954. MedlineGoogle Scholar8. Anderson A: Milkman's syndrome in idiopathic steatorrhoea complicated by refractory macrocytic anaemia, Lancet 2: 897, 1950. CrossrefMedlineGoogle Scholar9. Strang C: The Looser-Milkman syndrome—occurrence in a case of idiopathic steatorrhoea, Brit. J. Surg. 38: 489, 1951. CrossrefMedlineGoogle Scholar10. McLean FC: Activated sterols in treatment of parathyroid insufficiency, J. A. M. A. 117: 609, 1941. CrossrefGoogle Scholar11. Yu PN: The electrocardiographic changes associated with hypercalcemia and hypocalcemia, Am. J. M. Sc. 224: 413, 1950. CrossrefGoogle Scholar12. ScharfmanPropp WBS: Anemia associated with vitamin D intoxication, New England J. Med. 255: 1207, 1956. CrossrefMedlineGoogle Scholar13. LogeLangeMoore JPRDCV: Characterization of the anemia of chronic renal insufficiency, J. Clin. Investigation 29: 830, 1950. MedlineGoogle Scholar14. KaufmanBeckWiseman PRDRD: Vitamin D ("Ertron") therapy in arthritis—therapy followed by massive metastatic calcification, renal damage and death, J. A. M. A. 134: 688, 1947. CrossrefMedlineGoogle Scholar15. BurnettCommonsAlbrightHoward CHRRFJE: Hypercalcemia without hypercalciuria or hypophosphatemia, calcinosis and renal insufficiency, New England J. Med. 240: 787, 1949. CrossrefMedlineGoogle Scholar16. AndersonDentHarperPhilpott JCECGR: Effect of cortisone on calcium metabolism in sarcoidosis with hypercalcaemia—possibly antagonistic actions of cortisone and vitamin D, Lancet 2: 720, 1954. CrossrefGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: London, England*Received for publication May 22, 1959.From the King's College Hospital, London, England.Requests for reprints should be addressed to Paget Davies, M.B., Medical Registrar, King's College Hospital, Denmark Hill, London SE5, England. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byHypervitaminosis D, anaemia and renal failureAcute Hypercalcemia Simulating Basilar-Artery InsufficiencyThe Calciferol Requirements of Patients with Surgical HypoparathyroidismANTHONY W. IRELAND, M.B., JOHN S. CLUBB, M.B., FRANCIS C. NEALE, PH.D., SOLOMON POSEN, M.D., F.R.A.C.P., THOMAS S. REEVE, M.B.A CLINICAL COMPARISON OF TWO PREPARATIONS OF CALCIFEROLManagement of chronic renal failure 1 December 1960Volume 53, Issue 6Page: 1250-1254KeywordsCalciumExcretionIntoxicationMultiple myelomaPsoriasisRheumatoid arthritisSarcoidosisThyroidectomyToxicityVitamin D ePublished: 1 December 2008 Issue Published: 1 December 1960 PDF downloadLoading ...