tbuckley/cabot-search huggingface dataset:
Abstract 18793: Patients Awaiting Heart Transplantation on HeartWare Ventricular Assist Device Support for Greater than Two Years
Authors: Keith D Aaronson, Scott Silvestry, Simon Maltais, Hari R Mallidi, O.H. Frazier, Steven Boyce, David R Hathaway, Kevin B Najarian, Mark S Slaughter, Francis D Pagani
Journal: Circulation (2014)

Background: The use of left ventricular assist devices (VADs) as a bridge-to-transplant (BTT) for those with advanced heart failure is becoming more frequent. While there are potential risks and complications associated with VADs, the survival rate of patients placed on mechanical circulatory support is higher than in comparable patients managed with optimal medical therapies. Due to the increasing population affected by HF, further analysis of long term VAD performance is necessary.

Methods: Patients enrolled between August 2008 and November 2012 in the HeartWare® Bridge to Transplant (BTT) and Continued Access Protocol (CAP) trial who remained on support for more than 2 years were analyzed.

Results: Seventy four patients (19.4% (74/382) of the total patients in the BTT+CAP trial) remained on support for >2 years with a mean time on support of 967 days. Of these 74 patients, 47 (64%) were still on the wait list for a heart transplant. Of the 27 patients no longer listed, the most frequent reasons for delisting was BMI or weight contraindications (N=7) and patient decision/refusal (N=6). Compared to the patients on support for less than 2 years, the 74 patients were more frequently female, black/African American, had non-ischemic heart failure, and were INTERMACS profiles 3-7 at baseline. At six months and one year, patients on long-term support also had similar improvements in quality of life scores and improvements in distance walked in the 6 minute walk test. Post implant adverse event rates of bleeding, cardiac arrhythmias, infections, strokes, renal dysfunction and late right heart failure (see Table) were less frequent in patients on long term support. However, the rate of pump exchange for VAD thrombus was similar.

Conclusions: The HVAD successfully supported 74 of 382 patients for more than 2 years. Most of these patients are still listed and waiting for cardiac transplantation, and exhibit stable adverse event and quality of life profiles.

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Abstract 15845: Intracoronary Delivery of Exosomes Secreted by Cardiosphere-Derived Cells Confers Cardioprotection wWth Delayed Administration After Ischemia-Reperfusion Injury in Rats
Authors: Geoffrey de Couto, Prasanthi Durvasula, Ahmed Ibrahim, Eduardo Marbán
Journal: Circulation (2014)

Introduction: Cardiosphere-Derived Cells (CDCs) exert both regenerative and cardioprotective effects following ischemic insult to the myocardium despite limited cell engraftment. Here we demonstrate that exosomes (30-150nm lipid bilayer vesicles) secreted from human CDCs (hCDCs) confer a dose-dependent reduction in infarct size and preservation of cardiac function when infused into the coronary circulation in rats following ischemia/reperfusion (IR) injury.

Methods & Results: To examine the safety and efficacy of CDC-exosomes (EXOCDC), we performed a dose-finding study in Wistar-Kyoto rats (WKY; aged 8-12 weeks). Briefly, conditioned media was collected from hCDCs grown in serum-free media for 4 days then EXOCDCs were precipitated using ExoQuick-TC (SBI). As a starting dose, EXOCDCs were isolated from an equivalent, and previously-validated, CDC dose for intracoronary delivery following IR (3mL/3x105 CDCs). EXOCDC protein quantity was determined (~700ug/10mL) and doses were titrated. For in vivo analyses, WKY rats underwent 45 minutes of ischemia followed by 20 minutes of reperfusion. Animals were then randomly allocated to receive either PBS or a titrated dose of EXOCDC (derived from 10mL, 3mL, or 1mL CDC-conditioned media). Two days following injury, all EXOCDC doses (10mL, 3mL, and 1mL) conferred a significant reduction in percent infarct mass relative to PBS control (PBS: 13.56% vs. 10mL: 6.38%; 3mL: 6.94%; 1mL: 8.03% p<0.05). Similarly, ejection fraction was preserved in the lower doses (PBS: 43.07% vs. 10mL: 57.40%; 3mL: 58.17%; 1mL: 55.49%; p<0.05). Interestingly, these EXOCDC express a unique surface protein signature comprising some generic markers from exosomes (CD63, HSP70, but not CD9 or CD81) as well as CDC-specific markers (CD105).

Conclusions: Cell-free EXOCDC, delivered via the intracoronary route 20 min post-IR, are cardioprotective. The evaluation of efficacy at 48 hours rules out regenerative effects, which become manifest over weeks. The ability to delay administration after IR renders the protocol clinically-realistic. Thus, EXOCDC may be useful cardioprotective therapeutic candidates adjunctive to routine therapy for myocardial infarction.
T-Cell Precursors in Mice Bearing the Ehrlich Ascites Tumors 2
Authors: Enrico Clerici, Giuseppe Bigi, Gianni Garotta, Carla Porta, Paolo Mocarelli
Journal: JNCI Journal of the National Cancer Institute (1976)

Mice bearing Ehrlich ascites tumors and challenged with sheep erythrocytes produced fewer plaque-forming cells than did normal mice. At the same time the immunosuppression developed, the number of T lymphocytes in the thymus and spleen were reduced significantly. In the spleen, the number of B lymphocytes remained constant during carcinogenesis, whereas that of the macrophages increased significantly, as compared to the controls. In this paper, we demonstrated that the mechanism responsible for thymus and spleen depletion of theta antigen-bearing cells had to be ascribed to fewer T-lymphocyte precursors in the bone marrow of mice with cancer. The reduction of T-lymphocyte precursors was probably caused by the same "soluble factor(s)" produced by Ehrlich ascites tumor cells, which also interfered with the proliferation of myelopoietic stem cells in the bone marrow of mice with this neoplasm, as we previously reported. By performing several reconstitution experiments of lethally X-irradiated hosts, we determined that the immunodepression by Ehrlich ascites tumor cells was readily reversible, and the alteration of the T:B lymphocyte ratio in the spleen had a minor function, if any, in the pathogenesis of the immunosuppression.
Abstract 6133: Microvascular Dysfunction and Chronic Inflammation in Patients without Cardiovascular Risk Factors
Authors: Alejandro Recio-Mayoral, Justin C Mason, Juan C Kaski, Michael B Rubens, Olivier A Harari, Paolo G Camici
Journal: Circulation (2008)

Premature coronary atherosclerosis, which is actually seen as an active inflammatory process, is an established complication of systemic autoimmune diseases such as systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA). We hypothesized that exposure to chronic inflammation, even in the absence of classical cardiovascular risk factors (CVRF), could result in coronary microvascular dysfunction (CMD), an early marker of coronary atherosclerosis. By means of positron emission tomography in combination with oxygen-15 labeled water, myocardial blood flow (MBF) was measured at rest and during iv adenosine infusion (140 μg/kg/min) in 13 SLE and 12 RA patients (mean [±SD] age 44±10 years) without CVRF. All patients underwent coronary angiography using multi-slice (64 slices) computed tomography and only those with none or trivial coronary artery disease (&lt;30% luminal stenosis) were included. A group of 25 age- and gender-matched controls were also studied. There were no differences between patients and controls regarding body-mass index, blood pressure and lipid parameters. RA and SLE patients showed similar mean disease duration (16±11 and 11±7 years, respectively; p=0.12). Resting MBF was similar in patients and controls (1.25±0.27 vs 1.15±0.24 ml/min/g, p=0.15). However, during adenosine stress patients had lower MBF compared with controls (2.94±0.83 vs 4.11±0.84 ml/min/g, p&lt;0.001). As result, coronary flow reserve (CFR; adenosine/resting MBF) was significantly reduced in patients (2.44±0.78) compared with controls (3.81±1.07; p&lt;0.001). Seven patients showed ischemic electrocardiographic changes during adenosine and had a more severe reduction in CFR (1.76±0.81) and more years of disease (21±7 years) compared with those patients without ischemic changes (CFR 2.49±0.54; p=0.006; duration of disease 14±5 years; p=0.03). CFR was inversely correlated with years of disease (r=−0.65, p&lt;0.001), but not with corticosteroid cumulative dose (r=0.20, p=0.39). Chronic inflammation in the absence of traditional CVRF is characterized by severe CMD. This may represent an early marker of disease which precedes and contributes to premature coronary artery disease in patients with RA and SLE.
Abstract 18897: iPSC-derived Cardiomyocytes From a Patient With Hypertropic Cardiomyopathy Exhibit Imparied SR Ca Handling but No Change in Cytosolic Buffering Properties
Authors: Hyun Seok Hwang, Dmytro O Kryshtal, Verónica Sánchez-Freire, Joseph C Wu, Björn C Knollmann
Journal: Circulation (2014)

Introduction:  A recent report suggests that human induced pluripotent stem cell-derived cardiomyocytes (iPSC-CMs) from a familial hypertrophic cardiomyopathy (HCM) patient carrying a MYH7 mutation (R663H) exhibit altered Ca handling, but the underlying mechanisms remain unclear. We recently reported that HCM mutations can increase cytosolic Ca binding affinity, which could explain the abnormal Ca handling of HCM iPSC-CMs.   Hypothesis:  To test the hypothesis that the MYH7-R663H mutation alters cytosolic Ca buffering.   Methods and Results:  Human iPSCs derived from a healthy subject (CON) and a HCM patient (HCM: MYH7-R663H) were plated 21 days after cardiac induction at low density on Matrigel-coated dishes. iPSC-CMs were studied 3-4 days after plating using the ratiometric Ca indicator Fura-2AM at room temperature in Tyrode’s solution (2 mM Ca). HCM iPSC-CMs exhibited reduced Ca transients (measured during field-stimulation at 0.5 Hz) and SR Ca content (measured by caffeine spritz). Importantly, cytosolic Ca buffering was not significantly different between CON (Bmax=100±14μM/Lcytosol, Kd=0.61±0.09μM, n=25) and HCM iPSC-CMs (Bmax=115±10μM/Lcytosol, Kd=0.64±0.06μM, n=17). The rate constant of SR Ca uptake was significantly reduced in the HCM group (KSERCA: CON, 0.89±0.2s-1 vs. HCM, 0.45±0.1s-1, p=0.024) while Ca extrusion via the Na-Ca exchanger (KNCX) was only modestly reduced in HCM iPSC-CM (CON, 0.36±0.03s-1 vs. HCM, 0.26±0.03s-1, p=0.04). As a result, the relative contribution of Ca flux pathways was shifted from the SR to the cell membrane in HCM-iPSC-CM (Figure).   Conclusions:  Human iPSC-CMs from patients with HCM exhibit reduced SR Ca flux, but no change in cytosolic buffering.
Real-Time 3-Dimensional Echocardiographic Quantification of Left Ventricular Volumes
Authors: Victor Mor-Avi, Carly Jenkins, Harald P. Kühl, Hans-Joachim Nesser, Thomas Marwick, Andreas Franke, Christian Ebner, Benjamin H. Freed, Regina Steringer-Mascherbauer, Heidi Pollard, Lynn Weinert, Johannes Niel, Lissa Sugeng, Roberto M. Lang
Journal: JACC. Cardiovascular imaging (2008)
Experimentelle Physiologie und Pathologie der Verdauung (Chymologie).
Authors: E. S. London
Journal: JAMA (1925)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Spontaneous thrombosis in mice carrying the factor V Leiden mutation
Authors: Jisong Cui, Daniel T. Eitzman, Randal J. Westrick, Patricia D. Christie, Zuojun J. Xu, Angela Y. Yang, Anjali A. Purkayastha, Tony L. Yang, Alan L. Metz, Kim P. Gallagher, Julia A. Tyson, Robert D. Rosenberg, David Ginsburg
Journal: Blood (2000)
Abstract P238: Marijuana Use and Incident Diabetes: Results from the Coronary Artery Risk Development in Young Adults Study
Authors: Michael P Bancks, Mark J Pletcher, Stefan G Kertesz, Steve Sidney, Rana S Jamal, Pamela J Schreiner
Journal: Circulation (2014)

Marijuana use is common in the United States, but the cardiometabolic effects of marijuana use are unclear, specifically the association with incident diabetes. We examined the association between self-reported marijuana use and incident diabetes in the CARDIA Study, including 3,506 men and women aged 18-30 at the time of enrollment (1985-1986). In order to establish antecedent marijuana use, we classified marijuana use at enrollment and at exams 2, 5, and 7 (years later), and then followed individuals free of diabetes at year 7 for incident events. Marijuana use was modeled in three categories: never users (20% of the population), ever-past use (44% of the population), and ever-recent use (36% of the population). From 1992-2011, we observed 396 incident cases of diabetes ascertained at each exam via fasting glucose values (≥126 mg/dL), oral glucose tolerance test results (≥200 mg/dL), percentage of glycated hemoglobin (HbA1c ≥6.5%), or use of diabetes medications. Cox regression was used to estimate hazard ratios (HR) for incident diabetes according to marijuana use category, after adjustment for age, sex, race, smoking status, alcohol consumption, education, study center, body mass index, systolic blood pressure, LDL- and HDL-cholesterol, caloric intake, physical activity, and other illicit drug use. Results from crude analysis suggested decreased risk of incident diabetes for both ever-past (HR=0.81; 95% CI = 0.62 - 1.04) and ever-recent (HR=0.86; 95% CI = 0.66 - 1.13) marijuana use when compared to never users. In the multivariable model, neither ever-past (HR=1.03; 95% CI = 0.78 - 1.36) or ever-recent (HR=0.97; 95% CI = 0.70 - 1.36) marijuana use was associated with incident diabetes when compared to never users. The findings were not materially different after excluding the first three years of follow up. Marijuana use in young adulthood was not associated with incident diabetes in middle age.
Death and Life in Iraq
Authors: Zsolt T Stockinger
Journal: JAMA (2005)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Ejection fraction by radionuclide ventriculography and contrast left ventriculogram
Authors: Pedro E Ureña, Gervasio A Lamas, Gary Mitchell, Greg C Flaker, Sidney C Smith, Frans J Wackers, Patricia McEwan, Marc A Pfeffer
Journal: Journal of the American College of Cardiology (1999)

Objectives. We assessed the abilities of two methods to measure ejection fraction (EF)—radionuclide ventriculography (RVG) and contrast left ventriculography (Cath-EFa) to predict cardiovascular events. Background. Both RVG and Cath-EFa are commonly used methods to measure left ventricular performance and assess prognosis. Their comparative abilities to predict clinical events have not been reported. Methods. Both RVG EF and Cath-EFa were measured within 16 days of myocardial infarction (MI) in 688 patients. The results were divided into terciles. Prognosis by terciles was assessed for each technique. A multivariate analysis was performed to determine which EF measurement was a better predictor of prognosis. Results. Average RVG–EF was 32% ± 7, while Cath-EFa was 42% ± 10. Both RVG and Cath-EFa were poorly correlated (R = 0.42). Event rate declined across terciles with increasing EF for both techniques (events in lowest to highest tercile of Cath-EFa 40.7%, 25.9%, 11.6%, p < 0.001; and RVG-EF 39.9%, 26.1%, 15.6%, p < 0.001). There was concordance of terciles in 303 of 688 patients (44%). When patients in the highest RVG terciles were in the highest Cath-EFa tercile, the event rate was 7%. However, when patients in the highest RVG terciles were in the lowest Cath-EFa tercile, the event rate was 19%. Both Cath-EFa (p < 0.001) and RVG-EF (p < 0.001) were independent predictors of cardiovascular events. Conclusions. Ejection fraction measured by RVG or during catheterization is a valuable tool in the risk stratification of postinfarct patients. When disagreement is present between clinical impression and measurement by either method, the use of an alternative measurement is warranted and complementary.
To tell or not to tell
Authors: A N G Clark
Journal: BMJ (2001)

Whether it is correct to tell an elderly person how long he or she can expect to live, that is the question. In 50 years of work with elderly people, I have found it necessary only once to tell a patient that his expectation of life was short.

On my ward round I found a 72 year old man with a diagnosis of a large fungating carcinoma of the stomach …
Abstract 14302: Prediction of Conduction Velocity Based on Amplitude for Identification of Atrial Flutter Reentry
Authors: Taihei Itoh, Masaomi Kimura, Shingo Sasaki, Shingen Owada, Daisuke Horiuchi, Kenichi Sasaki, Yuji Ishida, Ken Okomura
Journal: Circulation (2011)

Local conduction velocity (LCV) in the low amplitude electrogram area is generally low. The quantitative relationship between LCV and bipolar electrogram amplitude (biEA) in the atria remains uncle...
Anaphylaxis to galacto‐oligosaccharides – an evaluation in an atopic population in <scp>S</scp>ingapore
Authors: J. Y. Soh, C.‐H. Huang, W. C. Chiang, G. V. Llanora, A. J. Lee, W. Loh, Y. L. C. Chin, V. Y. J. Tay, Y. H. Chan, D. Dianne, B. W. Lee
Journal: Allergy (2015)

Anaphylaxis to galacto-oligosaccharides (GOS), a prebiotic, has been described in atopic patients following its supplementation in commercial milk formula in South-East Asia. The epidemiology of this usual allergy to a carbohydrate is unknown. This study evaluated the prevalence of allergy to two formulations of commercial GOS, Vivinal™ GOS (vGOS) and Oligomate™ , in an atopic cohort. Atopic subjects (n = 487) from two specialist allergy clinics were surveyed via structured questionnaire and underwent skin prick tests to GOS. Subjects with positive skin prick tests to GOS (n = 30, 6.2%) underwent basophil activation tests, and a subset (n = 13) underwent oral challenge tests to both formulations of GOS. Six subjects had positive challenges to vGOS; and none to Oligomate. By extrapolating the BAT and oral challenge results, the prevalence of allergy to vGOS is estimated at up to 3.5% (95% CI 2.2-5.5%) of our atopic population. Our findings show that GOS allergy may be common amongst atopics in Singapore.
CHEMICAL CHANGES IN THE BLOOD OF PATIENTS WITH PYLORIC OBSTRUCTION
Authors: Paul H. Noth, Dwight L. Wilbur
Journal: Annals of Internal Medicine (1940)

Article1 February 1940CHEMICAL CHANGES IN THE BLOOD OF PATIENTS WITH PYLORIC OBSTRUCTIONPAUL H. NOTH, M.D., DWIGHT L. WILBUR, M.D., F.A.C.P.PAUL H. NOTH, M.D.Search for more papers by this author, DWIGHT L. WILBUR, M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-13-8-1285 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptFor a long time clinicians and surgeons have appreciated the fact that a close relationship exists between loss of gastric and duodenal content by vomiting or through a fistula and changes in the chemical composition of the plasma of the blood. The importance of recognizing these changes in patients suffering from pyloric obstruction in whom surgical treatment is to be carried out has been amply proved by the reduction in mortality which has followed adequate preoperative preparation of patients. While the mechanisms leading to some of the chemical changes, for example, elevation of the values for urea content of the...References1. PETERSVAN SLYKE JPDD: Quantitative clinical chemistry, vol. 1, 1931, The Williams and Wilkins Company, Baltimore, 1264 pp. Google Scholar2. WILBUR DL: The renal glomerulus in the various forms of nephrosis, Arch. Path., 1934, xviii, 157-185. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Rochester, Minnesota*Submitted for publication August 24, 1938.†Now residing in Detroit, Michigan.‡Now residing in San Francisco, California. Nextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 February 1940Volume 13, Issue 8Page: 1285-1296KeywordsBloodBlood plasmaFistulasMortalitySurgeonsUreaVomiting ePublished: 1 December 2008 Issue Published: 1 February 1940 Copyright & PermissionsCopyright, 1940, by The American College of PhysiciansPDF downloadLoading ...
8. Integrated self-inactivating lentiviral vectors produce full-length genomic transcripts competent for encapsidation and integration
Authors: Christian Bernloehr, Sascha Bossow, Sorin Armeanu, Guy Ungerechts, Michael Gregor, Wolfgang J. Neubert, Ulrich M. Lauer, Michael Bitzer
Journal: Molecular Therapy (2004)

Sendai virus as a prototype negative-strand RNA virus vector, keeps to be a promising new gene transfer system in the field of somatic gene therapy. However, future applications require the detailed characterization of safety issues for every new vector system and vector generation. To minimize immune responses and prevent an unrestrained spread of vector sequences, deletions of non-essential genes in the vector backbone are necessary. Therefore, prior to applications in a human setting, this study examined a possible mobilization of single or double gene deleted SeVV by related RNA viruses, being widely distributed as human pathogens.