DIFFERENTIATION OF MACROCYTIC ANEMIAS AND DIAGNOSIS OF PERNICIOUS ANEMIA AND SPRUE IN REMISSION BY ACCELERATED MEASUREMENT OF HEPATIC UPTAKE OF RADIOACTIVE Co^60B_12
Authors: G B J GLASS, L J BOYD
Journal: Annals of Internal Medicine (1957)

Article1 August 1957DIFFERENTIATION OF MACROCYTIC ANEMIAS AND DIAGNOSIS OF PERNICIOUS ANEMIA AND SPRUE IN REMISSION BY ACCELERATED MEASUREMENT OF HEPATIC UPTAKE OF RADIOACTIVE Co60B12GEORGE B. JERZY GLASS, M.D., F.A.C.P., LINN J. BOYD, M.D., F.A.C.P.GEORGE B. JERZY GLASS, M.D., F.A.C.P.Search for more papers by this author, LINN J. BOYD, M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-47-2-274 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe differential diagnosis of various types of macrocytic anemia often presents difficult clinical problems. Many cases of dietary folic acid or B12 deficiency and sprue cannot be distinguished from pernicious anemia by any available criterion. Moreover, very often pernicious anemia in remission or in a nonanemic stage, and the oligosymptomatic sprue, can be diagnosed only tentatively by history, since the clinical and hematologic findings following treatment, including B12 levels in blood, may be uninformative.In all these instances the determination of the presence or absence of Castle's intrinsic factor in the stomach has diagnostic significance, since its secretion is abolished...Bibliography1. Castle WB: Observations on etiologic relationship of achylia gastrica to pernicious anemia. 1. Effect of administration to patients with pernicious anemia of contents of normal human stomach recovered after ingestion of beef muscle, Am. J. M. Sc. 178: 748, 1929. CrossrefGoogle Scholar2. DoigWood RKLJ: Gastric biopsy in pernicious anemia, M. J. Australia 2: 565 (Oct. 14) 1950. CrossrefMedlineGoogle Scholar3. 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To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: New York, N. Y.*From the Symposium on Diseases of Intestinal Absorption, presented in part at the Thirty-eighth Annual Session of The American College of Physicians, Boston, Massachusetts, April 9, 1957.From the Department of Medicine and the Gastroenterology Research Laboratory, New York Medical College, Flower and Fifth Avenue Hospitals, New York, N. Y.This investigation was supported by Grant-in-Aid A-68 (C3) from the National Institutes of Arthritis and Metabolic Diseases, Public Health Service, and by Merck & Co., Inc., Rahway, New Jersey, and Organon, Inc., Orange, New Jersey.With the technical assistance of ROGER W. LAUGHTON, A. B., and HERMAN SCHAFFER, A. B.Requests for reprints should be addressed to George B. Jerzy Glass, M.D., Associate Professor of Medicine, New York Medical College, Flower and Fifth Avenue Hospitals, New York, N. Y. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByRadioisotopes as Applied to Diagnostic HematologyCoeliac DiseaseTHE DETERMINATION OF INTRINSIC FACTOR IN GASTRIC SECRETORY ANALYSISMeasurement of intestinal absorption of 57Co vitamin B12 by serum countingPaper electrophoretic analysis of b12 binding in human gastric juiceIntrinsic FactorVitamin B12 and Intrinsic FactorThe Malabsorption Syndrome, with Special Reference to The Effects of Wheat GlutenProblem3s in the Differentiation of the Megaloblastic AnemiasAbsorption of vitamin B12 in nutritional megaloblastic anaemiaRadiodiagnostik in der LeberklinikRadio-Vitamin B12 in der klinischen DiagnostikGastric Atrophy, Atrophic Gastritis, and Gastric Secretory FailureStudies on Robuden, extract from stomach and duodenumUltracentrifugation and paper electrophoresis of highly active intrinsic factor preparationsDeposition and Storage of Vitamin B12 in the Normal and Diseased LiverNutritional anemias with especial reference to vitamin B12PSYCHOLOGY OF LABORATORY ANIMALSORAL TREATMENT OF PERNICIOUS ANÆMIAGastric atrophy 1 August 1957Volume 47, Issue 2Page: 274-292KeywordsAnemiaFolic acidHospital medicineMedical servicesMetabolic disordersOral administrationPernicious anemiaResearch laboratoriesStomachThyroid Issue Published: 1 August 1957 PDF DownloadLoading ...