Hodgkin's Disease in Homosexual Men with Generalized Lymphadenopathy
Authors: Sonja L. Schoeppel, Richard T. Hoppe, Ronald F. Dorfman, Sandra J. Horning, Ann C. Collier, Terrence G. Chew, Lawrence M. Weiss
Journal: Annals of Internal Medicine (1985)

Brief Reports1 January 1985Hodgkin's Disease in Homosexual Men with Generalized LymphadenopathySONJA L. SCHOEPPEL, M.D., RICHARD T. HOPPE, M.D., RONALD F. DORFMAN, M.D., SANDRA J. HORNING, M.D., ANN C. COLLIER, M.D., TERRENCE G. CHEW, M.D., LAWRENCE M. WEISS, M.D.SONJA L. SCHOEPPEL, M.D., RICHARD T. HOPPE, M.D., RONALD F. DORFMAN, M.D., SANDRA J. HORNING, M.D., ANN C. COLLIER, M.D., TERRENCE G. CHEW, M.D., LAWRENCE M. WEISS, M.D.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-102-1-68 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe syndrome of persistent, generalized lymphadenopathy not attributable to an identifiable cause in homosexual men was first described in 1982 (1). Biopsy samples of the enlarged lymph nodes have shown a characteristic pattern of follicular or paracortical hyperplasia, or both (2, 3). These studies have suggested that this unexplained lymphadenopathy in homosexual men, the lymphadenopathy syndrome, may be part of the spectrum of the acquired immunodeficiency syndrome.We have recently noted Hodgkin's disease developing in patients with the lymphadenopathy syndrome. This finding is provocative because Hodgkin's disease and the lymphadenopathy syndrome are both associated with cellular immunodeficiencies (4-6). Also, these...References1. Persistent generalized lymphadenopathy among homosexual males. MMWR. 1982;31:249-51. MedlineGoogle Scholar2. METROKACUNNINGHAM-RUNDLESPOLLOCK CSM. Generalized lymphadenopathy in homosexual men. Ann Intern Med. 1983;99:585-91. LinkGoogle Scholar3. BRYNESCHANSPIRAEWINGCHANDLER RWTEF. Value of lymph node biopsy in unexplained lymphadenopathy in homosexual men. JAMA. 1983;250:1313-7. CrossrefMedlineGoogle Scholar4. BROWNHAYNESFOLEYGODWINBERARDCARBONE RHHHCP. Hodgkin's disease: immunologic, clinical, and histologic features of 50 untreated patients. Ann Intern Med. 1967;67:291-302. LinkGoogle Scholar5. TWOMEYRICE JL. Impact of Hodgkin's disease upon the immune system. Semin Oncol. 1980;7:114-25. MedlineGoogle Scholar6. GOTTLIEBGROOPMANWEINSTEINFAHEYDETELS MJWJR. The acquired immunodeficiency syndrome. Ann Intern Med. 1983;99:208-20. LinkGoogle Scholar7. YOUNGPERCYASIRE JCA. Cancer incidence and mortality in the United States. Natl Cancer Inst Monogr. 1981;57:72-84. Google Scholar8. MOSSBACCHETTIGORMAN APM. AIDS in the "gay" areas of San Francisco [Letter]. Lancet. 1983;1:923-4. CrossrefMedlineGoogle Scholar9. SMITHBUTLER JJ. Skin involvement in Hodgkin's disease. Cancer. 1980;45:354-61. CrossrefMedlineGoogle Scholar10. CASTELLINODUNNICKGOFFINETROSENBERGKAPLAN RNDSH. Predictive value of lymphography for sites of subdiaphragmatic disease encountered at staging laparotomy in newly diagnosed Hodgkin's disease and non-Hodgkin's lymphoma. J Clin Oncol. 1983;1:532-6. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. 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