tbuckley/cabot-search huggingface dataset:
Baseline Sodium-Lithium Countertransport and 6-Year Incidence of Hypertension
Authors: Martino Laurenzi, Massimo Cirillo, Walter Panarelli, Maurizio Trevisan, Rose Stamler, Alan R. Dyer, Jeremiah Stamler
Journal: Circulation (1997)

Background Sodium-lithium countertransport (Na-Li CT) activity is high in persons with hypertension. This study investigated whether high Na-Li CT relates to development of hypertension. Methods and Results At the baseline visit of the Gubbio Population Study, 4210 people of the 5376 surveyed were 18 to 74 years old; of these, 1599 were hypertensive (systolic pressure ≥140 mm Hg, or diastolic pressure ≥90 mm Hg, or on antihypertensive drug therapy). Of the 2611 nonhypertensives, 302 did not have Na-Li CT measured and 580 did not participate in 6-year follow-up. This analysis, therefore, deals with data collected on 1729 men 18 to 74 years old and women 18 to 74 years old who at baseline were nonhypertensive and had Na-Li CT measurement. Compared with individuals who were nonhypertensive at baseline and follow-up, individuals with incident hypertension at follow-up (systolic pressure ≥140 mm Hg, or diastolic pressure ≥90 mm Hg, or on antihypertensive drug therapy) had higher baseline values of Na-Li CT, blood pressure, age, body mass index, plasma cholesterol, and alcohol intake ( P &lt;.05). Baseline Na-Li CT was positively associated ( P &lt;.05) with development of hypertension in quartile analysis, with highest incidence of hypertension among men and women with Na-Li CT in the highest quartile (for men, ≥376 and for women, ≥311 μmol Li·L red blood cells −1 ·h −1 ). In univariate logistic regression, incidence of hypertension was related to baseline value of Na-Li CT, blood pressure, age, body mass index, plasma cholesterol, and alcohol intake ( P &lt;.05). In multiple logistic regression analysis, individuals with baseline Na-Li CT higher by 127 μmol (pooled SD for men and women) had 1.23 times greater risk of incident hypertension with control for sex and baseline age, body mass index, systolic pressure, and other confounders ( P &lt;.001). Conclusions Na-Li CT is a predictor of hypertension risk in adults.
Intracardiac electrogram width measurement for improved tachycardia discrimination: Initial results of a new implantable cardioverter-defibrillator (ICD)
Authors: Johannes Brachmann, Karlheinz Seidl, Bernd Hauer, Thomas Hilbel, Daniel Lighezan, Wolfgang Schoels, Thorsten Beyer, Jutta Ruf-Richter, Nicola Schwink, Jochen Senges, Wolfgang Kübler
Journal: Journal of the American College of Cardiology (1996)
Will Schools Add Insurance to the 3 Rs?
Authors: Rebecca Voelker
Journal: JAMA (1995)

AT THE LARGEST hospital emergency department in Volusia County, Florida, pediatric visits have dropped by 30% in the past 3 years. At the same time, pediatric emergency claims at one of the county's largest health maintenance organizations, the Florida Health Care Plan in Daytona Beach, have risen by 6% while its pediatric patient population has doubled. "This is not just a shift in who the payer was. We've been able to bring about a real shift out of the ER and into the physician's office," says Rose Naff, executive director of the Florida Healthy Kids Corporation in Tallahassee. The corporation directs one of the nation's first attempts to offer health insurance to children through the public school system. In its first few years of operation, Healthy Kids has provided coverage to more than 13000 children who have made 43000 trips to physicians' offices, had 30000 prescriptions filled, broken 300 bones,
Haemophilic Diseases in Denmark: A Classification of the Clotting Defects in 78 Haemophilic Families
Authors: L. TOCANTINS
Journal: JAMA (1961)

This is a monograph on hemophilia in Denmark, written by Dr. Sjølin when he was an assistant in the Carlsberg Foundation in Copenhagen. The work may be divided into 3 parts: the first dealing with the coagulation aspects of the hemophilia problem; the second with the clinical features of the disease; and the third, which occupies almost one-half of the volume, with the case histories of the patients observed by the author. The analysis of the data is thorough, and the statistical methods are complete. The thrombin generation test was widely employed in the study of coagulation defects and its use disclosed several interesting facts. There was, for example, a striking acceleration of the rate of thrombin generation after freezing of plasma. Dr. Sjølin also brought out the difference in distribution of number of platelets in hemophilics and normals. The monograph is rich in little-known observations on the coagulation defect
The Children of Atomic Bomb Survivors: A Genetic Study
Authors: Clark W. Heath
Journal: JAMA (1992)

Health follow-up studies of Japanese atomic bomb survivors have now been in progress for nearly 50 years, a remarkable tribute to sustained scientific cooperation between Japan and the United States since World War II. From the beginning, genetic research has received particular attention.  The first population-based work in Hiroshima and Nagasaki involved a large clinical-epidemiological investigation in which all late-term pregnancy outcomes were identified (nearly 77 000 pregnancies over a five-year period, 1948 through 1953) and then studied clinically in relation to parental exposure to bomb irradiation. No differences were found (in frequencies of birth defects, stillbirths, etc), thus allaying the immediate public concern that atomic radiation might spawn an epidemic of malformed children. Identification of the Fl generation continued thereafter for nearly the entire reproductive life of the exposed population (1945 through 1985). That work was coupled with clinical examination of all offspring of exposed parents, together with children
Mesenteric Lymphadenitis and Its Clinical Manifestations
Authors: G. D. F. McFadden
Journal: BMJ (1927)

MESENTERIC LYMPHADENITIS.degrees of pressure varying from that obtained by the gentle use of a breast pump to that resulting from vigorous digital expression.The greater the pressure the higher the percentage of fat.With a maximal amnunt of fluid in the milk and a minimal pressure on the areola, the contenit of fat might be 8 per cent.below that obtained when thel fluid was small in amount anid the piressure vigorous.When, however, the lpressure was maximal at the outset of a feed and minimal at the end, the per- centages of fat could be equialized or even inverted.She was convinced, tlherefore, that no two infants would get the same p)ercentage of fat from the same mother, even uinder idenitical conditions.It might be that the so-called overfed iiifant to wvhich Dr. Cameron had referred was r cally the vigorously sucking infant, who obtained not niecessarilv an excessive quantity of milk, but a milk with a very high percentage of fat.Dr. HELEN MACKAY, (London) emphasized the point that it was not only niecessary to have some knowledge of calorie valtues, but also to be able to instruct the mother as to the coniversion of weights of given foodstuffs inito the domestic measures available.She instanced the great variations that existed in this respect in different foodstuffs in common tise.
Lack of Adjustment for Body Mass Index
Authors: Patrick Mullie, Philippe Autier
Journal: JAMA Internal Medicine (2014)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Internal Medicine HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Internal Medicine journal
Where are the clinicians when you need them?
Authors: E. Halls
Journal: BMJ (2010)

Having spent the past 12 months working with patient groups and clinicians on a project to identify treatment uncertainties in prostate cancer, I have been amazed at the way people and organisations working in the same field don’t speak to each other. Have we become so competitive that we can’t see that working together is good, if not essential?

My frustration is growing, and the BMJ seems a good place to ask doctors: “Why the lack of communication?” Where is your culture of collaboration in my field of prostate cancer? Do you feel you have your own show, and all the answers?

We’re currently fighting our way towards an exciting collaboration between patients and clinicians designed to agree priorities in treatment research. There is so much we don’t understand about prostate cancer and no agreement as to the most important research. Our partners are the James Lind Alliance (an organisation established to help identify and confront the uncertainties about the effects of treatment), several other prostate cancer charities, the main patient support groups, and the Prostate Cancer Charter for Action. Progress is now being made, but …
Oral Opioid Therapy for Chronic Peripheral and Central Neuropathic Pain
Authors: Michael C. Rowbotham, Lisa Twilling, Pamela S. Davies, Lori Reisner, Kirk Taylor, David Mohr
Journal: New England Journal of Medicine (2003)

Although opioids are commonly used to treat chronic neuropathic pain, there are limited data to guide their use. Few controlled trials have been performed, and many types of neuropathic pain remain unstudied.
A Nonparametric Approach to Estimating Divergence Times in the Absence of Rate Constancy
Authors: M. J. Sanderson
Journal: Molecular Biology and Evolution (1997)

A new method for estimating divergence times when evolutionary rates are variable across lineages is proposed. The method, called nonparametric rate smoothing (NPRS), relies on minimization of ancestor-descendant local rate changes and is motivated by the likelihood that evolutionary rates are autocorrelated in time. Fossil information pertaining to minimum and/or maximum ages of nodes in a phylogeny is incorporated into the algorithms by constrained optimization techniques. The accuracy of NPRS was examined by comparison to a clock-based maximum-likelihood method in computer simulations. NPRS provides more accurate estimates of divergence times when (1) sequence lengths are sufficiently long, (2) rates are truly nonclocklike, and (3) rates are moderately to highly autocorrelated in time. The algorithms were applied to estimate divergence times in seed plants based on data from the chloroplast rbcL gene. Both constrained and unconstrained NPRS methods tended to produce divergence time estimates more consistent with paleobotanical evidence than did clock-based estimates.
Endoscopic Ultrasound-Guided Interstitial Brachytherapy of Unresectable Pancreatic Cancer: Results of a Pilot Trial
Authors: S. Sun, H. Xu, J. Xin, J. Liu, Q. Guo, S. Li
Journal: Endoscopy (2006)

Background and Study Aims: Intraoperative interstitial brachytherapy has been found to be effective when used during laparotomy to improve local control in patients with locally advanced pancreatic cancer. In this study, we report the results of using endoscopic ultrasound- (EUS-)guided interstitial brachytherapy in patients with advanced pancreatic cancer, with respect to tumor response, clinical response, safety, and complications. Patients and Methods: Fifteen patients (eight men, seven women; median age 61 years) with unresectable pancreatic adenocarcinoma were enrolled into the study, eight patients with stage III disease and seven patients with stage IV disease. A mean number of 22 radioactive seeds per patient were implanted into the tumors by EUS-guided needle puncture. The mean total implanted activity was 20 mCi, the minimum peripheral dose was 14 000 cGy, and the mean volume of implants was 52 cm3. Patients were followed-up by examination and by imaging tests every 2 - 3 months: clinical end points included the Karnofsky performance status and pain responses, tumor response (assessed by computed tomography and/or EUS), and survival. Results: During a median follow-up period of 10.6 months, the objective tumor response was classified as "partial" in 27 % of patients (with a median duration of partial response of 4.5 months), "minimal" in 20 % patients, and indicative of "stable disease" in 33 % of patients. Clinical benefit was shown in 30 % of patients, mostly due to reduction in pain, but this lasted for a limited time. Local complications (pancreatitis and pseudocyst formation) occurred in three patients; grade III hematologic toxicity occurred in three patients without serious clinical sequelae. Conclusions: EUS-guided intraoperative interstitial brachytherapy had a moderate local tumor effect and showed some clinical benefit in 30 % of the patients in this study. Combination of this form of treatment with external radiation and/or chemotherapy should be tested in future trials.
A 12‐week, placebo‐controlled study of the efficacy and safety of ebastine, 10 and 20 mg once daily, in the treatment of perennial allergic rhinitis
Authors: J Bousquet, Em Gaudaño, Ag Palma Carlos, H Staudinger
Journal: Allergy (1999)

This double‐blind, placebo‐controlled, multicentre study investigated the ability of ebastine, 10 and 20 mg once daily, to control symptoms of perennial allergic rhinitis (PAR) over a 12‐week period, and assessed additional benefits of the 20‐mg dose. Following a 2‐week baseline period, patients (12–63 years) were randomized to treatment with ebastine 10 mg ( n =88) or 20 mg ( n =102), or placebo ( n =100). Patients scored symptom severity (0–3) twice daily, and mean changes from baseline scores showed ebastine to be significantly effective in week 1. Control of symptoms persisted over the 12 weeks, the average daily total nasal symptom score for nasal stuffiness plus nasal discharge plus sneezing plus itchy nose being reduced by both doses, with statistical significance at 20 mg ( P =0.015 vs placebo) despite decreased usage of sodium cromoglycate rescue medications. Patient and clinician final opinions of treatment also significantly favoured ebastine, both 10 and 20 mg, over placebo. No serious adverse events occurred, and study treatments were well tolerated with a low incidence of central nervous system‐related adverse events and headache. In conclusion, ebastine 10 or 20 mg once daily was rapidly effective in relieving symptoms of PAR in adult and adolescent patients; additional benefits of the 20‐mg dose became apparent in the longer term.
Bullous pemphigoid in a 19-year-old woman. A case with unusual target antigens
Authors: O. MORI, H. HACHISUKA, M. KUSUHARA, Y. SASAI, S. FUJIWARA
Journal: British Journal of Dermatology (1994)

Journal Article Bullous pemphigoid in a 19‐year‐old woman. A case with unusual target antigens Get access O. MORI, O. MORI Department of Dermatology, Kurume University School of Medicine, 67 Asahimachi, Kurume, 830 Japan Search for other works by this author on: Oxford Academic Google Scholar H. HACHISUKA, H. HACHISUKA Department of Dermatology, Kurume University School of Medicine, 67 Asahimachi, Kurume, 830 Japan Search for other works by this author on: Oxford Academic Google Scholar M. KUSUHARA, M. KUSUHARA Department of Dermatology, Kurume University School of Medicine, 67 Asahimachi, Kurume, 830 Japan Search for other works by this author on: Oxford Academic Google Scholar Y. SASAI, Y. SASAI Department of Dermatology, Kurume University School of Medicine, 67 Asahimachi, Kurume, 830 Japan Search for other works by this author on: Oxford Academic Google Scholar S. FUJIWARA S. FUJIWARA Department of Dermatology, Medical College of Oita, 1‐1 Idaigaoka, Oita, 879–55 Japan Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 130, Issue 2, 1 February 1994, Pages 241–245, https://doi.org/10.1111/j.1365-2133.1994.tb02909.x Published: 01 February 1994 Article history Accepted: 19 March 1993 Published: 01 February 1994
The Quality of Life of Hemodialysis Recipients Treated With Recombinant Human Erythropoietin
Authors: Roger W. Evans
Journal: JAMA (1990)

Initial clinical trials with recombinant human erythropoietin provided evidence of a quality-of-life benefit for patients with anemic end-stage renal disease who received maintenance hemodialysis. As part of a phase III clinical trial of recombinant human erythropoietin, the quality of life of patients was systematically assessed. More than 300 patients at nine dialysis centers were evaluated. A statistically significant improvement was established between baseline and second follow-up on most objective and subjective quality-of-life parameters, including energy and activity level, functional ability, sleep and eating behavior, disease symptoms, health status, satisfaction with health, sex life, well-being, psychological affect, life satisfaction, and happiness. No change was observed in ability to work or employment status. We conclude that, in addition to substantial improvement in hematologic parameters, recombinant human erythropoietin greatly enhances the quality of life of anemic patients who receive maintenance hemodialysis.
Nitrogen Mustard in Treatment of Bronchial Carcinoma
Authors: S. G. McAlpine
Journal: BMJ (1956)

In our present state of knowledge surgical treatment offers the only hope of cure for patients with bronchial carcinoma.When the condition is inoperable it is generally agreed that treatment should be directed to the relief of symptoms, and that when the lesion is of limited extent radiotherapy is the best palliative measure.As an alternative to radiotherapy in the inoperable cases, nitrogen mustard has some claims for consideration, and in this unit an attempt has been made during the past eight years to assess its value.Oswald ( 1956), quoting Smithers (1951), stated that none of the chemotherapeutic agents " seems to have the slightest beneficial effect upon bronchial carcinomata."This statement has prompted the present attempt to review the value of nitrogen mustard in this field.
High vCJD rates in Scotland could be due to poor diet
Authors: B. Christie
Journal: BMJ (2001)

The rate of contracting variant Creutzfeldt-Jakob disease (vCJD) has been found to be twice as high in Scotland and the north of England as elsewhere in Britain, leading to speculation that poorer diets in these areas may be responsible for the increased risk.

Professor James Ironside, the senior pathologist at the National CJD Surveillance Unit in Edinburgh, said that the more frequent consumption of cheap meat products such as pies and burgers in the north of Britain may explain the difference. …
Erbin interacts with TARP γ-2 for surface expression of AMPA receptors in cortical interneurons
Authors: Yanmei Tao, Yong-Jun Chen, Chengyong Shen, Zhengyi Luo, C Ryan Bates, Daehoon Lee, Sylvie Marchetto, Tian-Ming Gao, Jean-Paul Borg, Wen-Cheng Xiong, Lin Mei
Journal: Nature Neuroscience (2013)
Life-style factors and hand eczema
Authors: I. Anveden Berglind, M. Alderling, B. Meding
Journal: British Journal of Dermatology (2011)

Background Previous knowledge of the impact of certain life‐style factors on hand eczema is scanty. Objectives To investigate a possible association between hand eczema and life‐style factors such as obesity, physical exercise, stress, smoking and alcohol consumption. Methods In a cross‐sectional public health survey in Stockholm, Sweden, 27 994 (58%) randomly chosen individuals aged 18–64 years completed a postal questionnaire regarding physical and mental health, social relations, economic status and work. Of these, 27 793 individuals responded to the question regarding hand eczema and were included in the present study. The association between life‐style factors and hand eczema was analysed by prevalence proportion ratios (PPR), using a generalized linear model. Results Hand eczema was more common among individuals who reported high stress levels, PPR 1·326 (95% CI 1·303–1·350). There was also a positive dose–response relationship between hand eczema and stress. Hand eczema was less common among individuals reporting high physical exercise, and most apparent in women, PPR 0·781 (95% CI 0·770–0·792). Men who reported high alcohol intake reported hand eczema less often, PPR 0·958 (95% CI 0·930–0·987). Obese individuals reported hand eczema more commonly, PPR 1·204 (95% CI 1·174–1·234). There was a slight increase of hand eczema among smokers, PPR 1·025 (95% CI 1·006–1·044). Conclusions Hand eczema was more common in individuals who reported stress, obesity and smoking. In individuals who reported high physical exercise levels hand eczema was less common. As there appears to be an association between life‐style factors and hand eczema it is important to consider life‐style factors in clinical practice.
Abstract LB-216: CSLEX (sialyl LewisX) is an important and useful tumor marker in monitoring breast cancer patients
Authors: Tomoyuki Fujita, Naoya Nagura, Kayoko Koshikawa, Hajime Nishimura, Ken-ichi Ito, Minoru Fujimori
Journal: Cancer Research (2010)

Abstract Background: CSLEX-1 is one of the monoclonal antibodies for which the structure of the antigen is known. This antigen is called CSLEX (Sialyl Le X). It has been reported that CSLEX may be more useful than CEA in combination with CA15-3 in monitoring breast cancer patients. Methods: We measured and evaluated the serum levels of some tumor markers, including CSLEX, in a total of 482 breast cancer patients with or without metastasis who consecutively visited the outpatient clinic of the Division of Breast and Endocrine Surgery, Shinshu University Hospital, between April 2007 and September 2007. Results: All serum levels of tumor markers in a single measurement correlated significantly with the status of metastasis (P &amp;lt; 0.01). All combinations of combined measurements, such as CEA and CA15-3, CEA and NCC-ST439, CEA and CSLEX, CA15-3 and NCC-ST439, and CA15-3 and CSLEX, also correlated significantly with the status of metastasis (P &amp;lt; 0.01). The sensitivity, specificity, positive-predictive value, negative-predictive value and accuracy were almost the same between CSLEX and NCC-ST439, which belongs to the type II carbohydrate antigens. The cut-off values of serum CSLEX and NCC-ST439 were 38.8 ± 52.7 U/ml and 22.1 ± 27.8 U/ml, respectively (P = 0.16). Conclusions: These data support there are no differences between CSLEX and NCC-ST439 as diagnostic parameters in single or combined measurements. The cut-off value of serum CSLEX tended to be higher compared with that of NCC-ST439.Patient characteristics Without MetastasisWith MetastasisP-valueNumber363119 Mean Age ± SD (years)56.5 ± 11.758.9 ± 12.60.06CEA2.5 ± 6.311.9 ±34.50.008CA15-311.9 ± 11.166.4 ± 162.50.001BCA22561.0 ±51.5139.4 ± 228.60.001NCCST-4392.0 ± 2.234.2 ± 108.20.003CSLEX3.4 ± 3.765.6 ± 223.10.005Diagnostic parameters for the detection of breast cancer metastasis using tumor markers (%) SensitivitySpecificityPPVNPVAccuracySingle measurement CEA3095688179CA15-33498828282BCA2251698707878NCC-ST4392497727979CSLEX2397697978Combined measurement CEAandCA15-34893698482CEA and NCC-ST4394392648380CEA and CSLEX4392658380CA15-3 and NCC-ST4394595758483CA15-3 and CSLEX4495738482 Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 101st Annual Meeting of the American Association for Cancer Research; 2010 Apr 17-21; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2010;70(8 Suppl):Abstract nr LB-216.