tbuckley/cabot-search huggingface dataset:
TRICHOSTRONGYLUS INFESTATION WITH PROFOUND EOSINOPHILIA
Authors: L WALLACE, R HENKIN, A W MATHIES
Journal: Annals of Internal Medicine (1956)

Case Reports1 July 1956TRICHOSTRONGYLUS INFESTATION WITH PROFOUND EOSINOPHILIALEON WALLACE, M.D., RAYMOND HENKIN, M.D., ALLEN W. MATHIES, B.A.LEON WALLACE, M.D., RAYMOND HENKIN, M.D., ALLEN W. MATHIES, B.A.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-45-1-146 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptINTRODUCTIONAlthough trichostrongyliasis of humans is commonly found in such areas as Turkey, Iran, India, Japan, Korea and China, very few cases have been reported in the United States.1-5 Although there are various species of this parasite which infest animals Trichostrongylus orientalis is the species found in man in areas of heavy human infestation.The condition is so rare in this country that such common standard texts on gastroenterology as Bockus and Portis contain no mention of it.Trichostrongyliasis is a nematode infection which is probably acquired by ingestion of the filariform larvae. The adult form inhabits the upper small...Bibliography1. SchenkenMoss JREC: Trichostrongylus colubrifornis in human appendix: report of case in Louisiana, J. Lab. and Clin. Med. 24: 15, 1938. Google Scholar2. TsuchiyaReller HH: A case of trichostrongylus infection with notes on the identification of ova, J. Lab. and Clin. Med. 30: 262, 1945. Google Scholar3. O'NealMagath RTB: Trichostrongylus infection in human beings: report of three cases, Proc. Staff Meet., Mayo Clin. 22: 193, 1947. MedlineGoogle Scholar4. EvanderDoyle LCWM: Trichostrongylus infection in human beings: need for differentiation from hookworm, J. Lab. and Clin. Med. 33: 869, 1948. MedlineGoogle Scholar5. SpiroShropshireFugelso HMCNES: Pseudo-hookworm: trichostrongylus infestation in man, Am. J. Digest. Dis. 21: 83, 1954. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: *Received for publication April 18, 1955.From the Medical Department, Fort McClellan Army Hospital, Alabama.Requests for reprints should be addressed to Leon Wallace, M.D., 6423 Wilshire Boulevard, Los Angeles-48, California. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byThe Community of Nematodes Inhabiting the Human GutClinical and haematological characteristics of human trichostrongyliasisPrevalence and clinical aspects of human Trichostrongylus colubriformis infection in Lao PDROther Tissue Nematode InfectionsAbdominal pain and eosinophilia in suburban goat keepers — trichostrongylosisBlood eosinophilia in adult bantams naturally infected with Trichostrongylus tenuisHaematology, weight and condition of captive red grouse (Lagopus lagopus scoticus) infected with caecal threadworm (Trichostrongylus tenuis)Oxyuris, Trichostrongylus and Trichuris 1 July 1956Volume 45, Issue 1Page: 146-150KeywordsDiarrheaEosinophiliaIngestion ePublished: 1 December 2008 Issue Published: 1 July 1956 PDF downloadLoading ...
Abstract 15761: Improving RBC K Uptake and Its Impact on Myocardial Ischemia and Electrical Regeneration of the Heart: A Novel Therapeutic Approach
Authors: Antonio Delgado-Almeida, Carlos Luis Delgado, Antonio Delgado-Leon
Journal: Circulation (2010)

Introduction: Since red-blood cell K (RBCK) plays a key role on Hb-O2/CO2 exchanges, we tested the hypothesis that increasing RBCK improves myocardial-O2. Aim: to evaluate the effect of a new compo...
Shiga toxin-producing Escherichia coli (STEC) O157 outbreak, The Netherlands, September – October 2005
Authors: Y Doorduyn, C M de Jager, W K van der Zwaluw, I H Friesema, A E Heuvelink, E de Boer, W J B Wannet, Y T H P van Duynhoven
Journal: Eurosurveillance (2006)

In September 2005, the first national food-related outbreak of Shiga toxin (Stx)-producing Escherichia coli (STEC) O157 was investigated in the Netherlands. A total of 21 laboratory-confirmed cases (including one secondary case), and another 11 probable cases (two primary and nine secondary cases) were reported in patients who became ill between 11 September and 10 October 2005. Preliminary investigation suggested consumption of a raw beef product, steak tartare (in the Netherlands also known as "filet americain"), and contact with other symptomatic persons as possible risk factors. A subsequent case-control study supported the hypothesis that steak tartare was the source of the outbreak (matched odds ratio (OR) 272, 95% confidence interval (CI) 3-23,211). Consumption of ready-to-eat vegetables was also associated with STEC O157 infection (matched OR 24, 95% CI 1.1-528), but was considered a less likely source, as only 40% of the cases were exposed. Samples of steak tartare collected from one chain of supermarkets where it is likely that most patients (67%) bought steak tartare, all tested negative for STEC O157. However, sampling was done three days after the date of symptom onset of the last reported case. Since 88% of the cases became ill within a two week period, point source contamination may explain these negative results. It is concluded that steak tartare was the most likely cause of the first national food-related outbreak of STEC O157 in the Netherlands.
Preventing renal failure in the critically ill
Authors: M. J O'Leary
Journal: BMJ (2001)

Few doctors trained in the past 20 years have not learnt of the benefits of “low dose” dopamine in patients developing acute renal failure. The belief that low dose dopamine is beneficial was based on the physiological and pharmacological properties of dopamine and on personal anecdotes, but there is a lack of clinical trials, those available being of poor quality.1 The recent publication of a high quality randomised, double blind, placebo controlled study2 showing no benefit of “low dose” dopamine has, therefore, killed—or at least mortally wounded given that it takes time for cardiac surgeons to catch up—one of critical care's sacred cows.

In this study 328 patients (in 23 Australasian intensive care units) with an acute inflammatory response and early renal dysfunction (raised serum creatinine concentration or oliguria) randomly received a dopamine infusion (2 μg/kg/min) or placebo. The primary outcome variable, peak serum creatinine concentration during infusion, did not differ between the well matched groups. Moreover, there was no difference in any other variable studied, including requirement for dialysis. Indeed, urine output and use of frusemide did not differ, suggesting that dopamine was not even an effective diuretic. A possible criticism of the …
Abstract 4689: Ruptured Thin-capped Fibroatheromas in Acute St Elevation Myocardial Infarction: A Virtual Histology Intravascular Ultrasound Analysis
Authors: Sang-Wook Kim, Gary S Mintz, Seong-Hoon Lim, Young Joon Hong, Sung Yun Lee, Jang Ho Bae, Seong Ho Hur, Hyun Jae Kang, Jin Weon Kim, Gi Hwan Kim, Wang Soo Lee, Chee Jeong Kim, Wang Seong Ryu, Neil J Weissman
Journal: Circulation (2009)

We assessed Virtual Histology Intravascular Ultrasound (VH-IVUS) thin-capped fibroatheromas (VH-TCFAs) in pts with acute ST elevation myocardial infarction (STEMI). VH-TCFAs were defined as necroti...
Navitoclax enhances the activity of taxanes in non-small cell lung carcinoma (NSCLC) models
Authors: Nguyen Tan, Mehnaz Malek, Jiping Zha, Robert Kassees, Leanne Berry, Wayne J. Fairbrother, Deepak Sampath, Lisa Belmont
Journal: Clinical Cancer Research (2010)

Abstract Navitoclax (formerly ABT-263) is a small molecule that potently antagonizes the activity of Bcl-2, Bcl-xL, and Bcl-w. To determine the potential of this molecule in combination with taxane-based chemotherapy, we evaluated a panel of 33 human NSCLC cell lines with a dose matrix of paclitaxel and navitoclax. All cell lines exhibited a greater than additive response to the combination, suggesting a synergistic interaction. These results were extended to mouse xenograft tumor models, in which the combination was more efficacious than either single agent docetaxel or navitoclax. Live cell time-lapse microscopy was used to demonstrate that the addition of navitoclax to paclitaxel decreases the time from mitotic entry to cell death and changes cell fate from mitotic slippage to death during mitotic arrest. The relative levels of Bcl-xL and Mcl-1 correlate with the extent of synergy as measured by a Bliss independence model, suggesting that cancers with high levels of Bcl-xL will be relatively resistant to taxane-based therapy, but could benefit from addition of navitoclax to taxane treatment. Finally, a significant percentage of NSCLC patient samples exhibit high Bcl-xL levels, indicating the potential for broad utility of this combination in lung cancer.
Scientists Probe Shutting Down Cancer Cells by Awakening Silenced Genes
Authors: Tracy Hampton
Journal: JAMA (2004)

ORLANDO—Before any perceptible signs of disease, even before a single tumor cell divides and starts a malignant cascade, the first event that leads to cancer is a change in gene expression. Scientists have discovered many cases in which mutations in the DNA sequence—such as point mutations or deletions—alter gene expression and set the stage for cancer. But as scientists strive to decipher which genetic changes can make cells cancerous, they are also discovering that not all such changes involve mutations that alter the DNA sequence. Rather, some are a result of “epigenetic” modifications, heritable changes in gene function that occur without any mutation in gene sequence. At the annual American Association for Cancer Research Conference in Orlando in late March, experts spoke of ongoing investigations into the epigenetic aspects of cancer development and how this field might contribute to the detection and treatment of cancer.
Abstract 38: North American LUCAS Evaluation: Prehospital Use of a Mechanical Chest Compression System
Authors: Dana A Yost, Louis Gonzales, Charles J Lick, Paul Satterlee, Michael Levy, Joseph Barger, Pamela Dodson, Fred W Chapman, Robert A Niskanen
Journal: Circulation (2010)

Background: Sudden cardiac death (SCD) is a major clinical and public health problem. Because cardiac arrest outcomes are improved by CPR, the 2005 AHA guidelines have placed renewed emphasis on th...
Detection of urinary tract infections by reduction of nitroblue tetrazolium
Authors: Shannon D. Smith, Marcia A. Wheeler, Robert M. Weiss
Journal: Kidney International (1998)

Detection of urinary tract infections by reduction of nitroblue tetrazolium. Technical Note.BackgroundNitroblue tetrazolium (NBT) reduction to formazan has been used as a marker for nitric oxide synthase (NOS). Since inducible NOS activity is elevated in urine from patients with urinary tract infections (UTIs), we investigated the accuracy of NBT reduction as an early predictor of UTIs and quantified the relationship between inducible NOS and NBT.MethodsUrine samples from 434 patients were screened for the presence of UTIs with leukocyte-esterase and nitrite dipsticks and with NBT reduction. The rapid screening results from each test were compared to urine culture results. In addition, NBT reduction parameters were measured in urine pellet at 595 nm after incubation with one of four factors: NOS cofactors, NOS inhibitors, NADH, or superoxide dismutase/catalase.ResultsAs a urine screening test for UTIs, NBT reduction was more sensitive with a higher negative predictive accuracy than the nitrite dipstick. NBT reduction also was more specific with a higher positive predictive accuracy and negative predictive accuracy than the leukocyte-esterase dipstick. In infected urine pellet, both NADPH, a NOS cofactor, and NADH increased NBT reduction. Superoxide dismutase/catalase decreased NBT reduction.ConclusionsAlthough NOS may not be the only NBT reducing enzyme, rapid, visible reduction of NBT is induced in urine from patients with UTIs. Detection of urinary tract infections by reduction of nitroblue tetrazolium. Technical Note. Nitroblue tetrazolium (NBT) reduction to formazan has been used as a marker for nitric oxide synthase (NOS). Since inducible NOS activity is elevated in urine from patients with urinary tract infections (UTIs), we investigated the accuracy of NBT reduction as an early predictor of UTIs and quantified the relationship between inducible NOS and NBT. Urine samples from 434 patients were screened for the presence of UTIs with leukocyte-esterase and nitrite dipsticks and with NBT reduction. The rapid screening results from each test were compared to urine culture results. In addition, NBT reduction parameters were measured in urine pellet at 595 nm after incubation with one of four factors: NOS cofactors, NOS inhibitors, NADH, or superoxide dismutase/catalase. As a urine screening test for UTIs, NBT reduction was more sensitive with a higher negative predictive accuracy than the nitrite dipstick. NBT reduction also was more specific with a higher positive predictive accuracy and negative predictive accuracy than the leukocyte-esterase dipstick. In infected urine pellet, both NADPH, a NOS cofactor, and NADH increased NBT reduction. Superoxide dismutase/catalase decreased NBT reduction. Although NOS may not be the only NBT reducing enzyme, rapid, visible reduction of NBT is induced in urine from patients with UTIs.
Abstract 18264: Abnormalities in the Electrocardiogram: a Meta-Analysis Comparing Chagas Disease to Other Cardiomyopathies
Authors: Rhanderson N Cardoso, Gilson Fernandes, Daniel Garcia, Mohammad Ansari, Raul D Mitrani
Journal: Circulation (2014)

Introduction: Chagas Disease (CD) has been associated with a variety of abnormalities in the electrocardiogram (ECG). For epidemiologic purposes and differential diagnosis, we sought to perform a systematic review and meta-analysis of the relative frequencies of various ECG findings in patients with CD compared to a non-CD group. Hypothesis: ECG abnormalities differ significantly based on etiology of cardiomyopathy. Methods: PubMed, EMBASE, Cochrane Central and Latin American databases were searched for studies that directly compared the prevalence of ECG abnormalities in CD patients to a non-CD group. Odds-ratios were computed using a random-effects model due to anticipated heterogeneity. We further performed a subanalysis on studies that included only patients with known cardiomyopathy. Results: A total of 17 studies and 10,550 patients were included, of whom 4,192 (39.7%) had a positive serology for CD. Ten studies included only patients with known cardiomyopathy in both the control and CD groups. Table 1 reports the odds-ratios for the relative frequencies of various ECG abnormalities between groups. Conclusions: Our analysis suggests that amongst patients with cardiomyopathies, Chagas Disease etiology is significantly associated with an increased prevalence of right bundle branch block, premature ventricular complexes and permanent pacemaker implantation, whereas left bundle branch block is more prevalent among other cardiomyopathies. The combination of right bundle branch block with left anterior fascicular block had the highest odds ratio for prevalence among Chagas Disease patients.
FDA Oncology Tools on Internet
Authors: Jane E. Henney
Journal: JAMA (2000)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Myotatic, Kinesthetic and Vestibular Mechanisms.
Authors: Don C. Higgins
Journal: Annals of Internal Medicine (1968)

The quality of the published Ciba Foundation Symposia has always been high, and the present volume is no exception.Its title is perhaps a rather % daunting one and the reviewer would have a slight prejudice in favour of something simpler, such as 'Muscle control and balance'.The subjects which were, in fact, discussed in the first section of the symposium, included * the innervation of skeletal muscle, stretch receptors, stretch reflexes, and afferent systems involved in proprioception.The second section was con- cerned with the fine structure of the vestibular system, and the third with the nervous pathways involved in vestibular influences.A final section was devoted to clinical aspects of vestibular disorders.All of these subjects are ones in which there have been striking advances in recent years; they illustrate the fact that this is a rapidly growing field for both clinical and basic research.No one who studies this book can fail to be impressed by the contribution that neuro-otology is making to the care and treatment of patients.r. w.G.
Children with bronchopulmonary dysplasia (BPD) have increased dynamic flow limitation and an altered ventilatory response to exercise
Authors: Christopher O'Dea, Karla Logie, Andrew Wilson, Andrew Maiorana, Jane Pillow, Graham Hall
Journal: European Respiratory Journal (2011)

Introduction: Children born preterm are known to have altered lung structure and function. These changes may lead to dynamic flow limitation (DFL) during exercise. This study aimed to determine the prevalence of DFL and the ventilatory response to exercise in preterm children aged 9-11yrs with and without BPD.

Methods: Preterm children ( 28 d supplemental O2 at 36 w post menstrual age) and term born healthy controls performed an incremental treadmill exercise test to volitional exhaustion with breath by breath analysis and exercise tidal flow volume loops.

Results: To date 89 children (33 BPD, 25 nonBPD and 31 controls) performed acceptable exercise tests. Children with BPD were more likely to have DFL (n=15, 36%) compared to nonBPD (n=3, 11%) and term controls (n=2, 6.3%) p<0.05. The pre-term children had a significantly lower peak V'O2 than the term born controls (43.8 vs . 49.8. mL/kg/min, p<0.001). Children with BPD had a reduced O2 pulse (p<0.001), tidal volume and V'E (p<0.001) compared to nonBPD and term controls. Preterm children with dynamic flow limitation had lower FEV1 z-scores compared to those without (p<0.02) with other ventilatory responses to exercise not altered in the presence of DFL.

Conclusion: Children born preterm have a lower aerobic exercise capacity and those with BPD exhibit both cardiac and respiratory limitation to exercise. The presence of DFL in children born pre-term with BPD is a novel finding and further research on its potential impact is required.
BRCA1 Is a Novel Regulator of Endothelial Function and Limits Atherosclerosis
Authors: Krishna K Singh
Journal: Circulation (2009)

Abstract #4219 Krishna K Singh, Praphulla C Shukla, Adrian Quan, St Michaels Hosp, Toronto, ON, Canada; Mohammed Al-Omran, King Saud Univ, Riyadh, Saudi Arabia; Paul Jurasz, Univ of Alberta, Edmonton, AB, Canada; Fina Lovren, Yi Pan, Christine Brezden-Masley, St Michaels Hosp, Toronto, ON, Canada; Alistair J Ingram, McMaster Univ, Hamilton, ON, Canada; Lee Errett, Hwee Teoh, Subodh Verma, St Michaels Hosp, Toronto, ON, Canada Krishna K Singh, 2009 Finalist and Presenting Author
Dissemination of IncFII plasmids carrying rmtB and qepA in Escherichia coli from pigs, farm workers and the environment
Authors: Y. Deng, Z. Zeng, S. Chen, L. He, Y. Liu, C. Wu, Z. Chen, Q. Yao, J. Hou, T. Yang, J.-H. Liu
Journal: Clinical Microbiology and Infection (2011)
Abstract 14163: Oxidized Phospholipids and Lipoprotein-Associated Phospholipase A2 in Plasma, ApoB-containing and ApoAI -containing Lipoprotein Subfractions in Patients with Familial Hypercholesterolemia: Effect of LDL Apheresis
Authors: Kiyohito Arai, Alexina Orsoni, Elizabeth R Miller, Joseph L Witztum, M. John Chapman, Sotirios Tsimikas
Journal: Circulation (2010)

Objectives:  Lp(a) is a causal, genetic risk factor for cardiovascular disease (CVD) and is enriched in pro-inflammatory oxidized phospholipids (OxPL) and lipoprotein-associated phospholipase A2 (Lp-PLA2). Epidemiologic outcomes studies have shown that the OxPL, Lp(a) and Lp-PLA2 collectively mediate additive risk for CVD. To derive new insights into these findings, we evaluated the impact of apheresis on lipoprotein-associated OxPL and Lp-PLA2 mass in pts with familial hypercholesterolemia (FH).   Methods:  Patients with FH (n=18) on chronic LDL apheresis were divided into three groups according to low (   Results:  In plasma and subfractions, OxPL were present primarily on Lp(a), but minimally on non-Lp(a)-apoB or apoAI. OxPL were almost exclusively detected in density 1.059-1.094 g/ml where Lp(a) is prevalent and in proportion to the amount of Lp(a) present. In plasma and subfractions, Lp-PLA2 was present primarily on apoB particles; however the proportion of Lp-PLA2 decreased in apoB-containing subfractions but progressively increased in Lp(a) as Lp(a) plasma levels increased. LDL apheresis resulted in significant reductions of OxPL and Lp-PLA2 in plasma, in apoB-containing subfractions and on isolated apoB and Lp(a).   Conclusions:  By physical separation and immunological techniques, OxPL are primarily present on the Lp(a) particle. Lp-PLA2 is present primarily on apoB-containing particles but the proportion on Lp(a) increases as plasma Lp(a) levels increase. These data suggest that Lp(a), OxPL and Lp-PLA2 are pathophysiologically linked, particularly as Lp(a) levels increase, and provide a rationale for understanding their interactive role in mediating atherothrombosis and CVD in humans.