TREATMENT OF CHRONIC BLOOD DONOR ANEMIA
Authors: J C BATEMAN
Journal: Annals of Internal Medicine (1951)

Article1 February 1951TREATMENT OF CHRONIC BLOOD DONOR ANEMIAJEANNE C. BATEMAN, M.D.JEANNE C. BATEMAN, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-34-2-393 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe composition of a molecule of hemoglobin is 96 per cent protein in the form of globin. According to Schmidt,1 globin contains 15 amino acids, with lysine and histidine comprising 45 per cent of the amino acid total. In studies on anemic dogs, however, Whipple2 demonstrated that feedings of specific amino acids did not result in hemoglobin regeneration in proportion to the component of the particular acid in globin. This fact emphasizes the complex process of globin synthesis in the body.It is understandable that limitation of available dietary protein might not only result in anemia but might also slow...Bibliography1. Schmidt CL: Chemistry of the amino acids and proteins, 1938, Charles C. Thomas, Springfield, Ill. Google Scholar2. WhippleRobscheit-Robbins GHFS: Amino acids and hemoglobin production in anemia, J. Exper. Med. 71: 569-583, 1940. CrossrefMedlineGoogle Scholar3. HahnWhipple PFGH: Hemoglobin production in anemia limited by low protein intake; influence of iron intake, protein supplements and fasting, J. Exper. Med. 69: 315-326, 1939. CrossrefMedlineGoogle Scholar4. Robscheit-RobbinsMillerWhipple FSLLGH: Hemoglobin and plasma protein, J. Exper. Med. 78: 375-396, 1943. CrossrefGoogle Scholar5. Jencks Z: Studies in the regeneration of blood, Am. J. Physiol. 59: 240-253, 1922. CrossrefGoogle Scholar6. McCay CM: Influence of protein, blood, liver, fat, iron and potassium in diet upon rate of blood regeneration after hemorrhage in rat and dog, Am. J. Physiol. 84: 16-35, 1928. CrossrefGoogle Scholar7. KitzesElvehjemSchuette GCAHA: Determination of blood plasma iron, J. Biol. Chem. 155: 653-660, 1944. CrossrefGoogle Scholar8. Wintrobe MM: Clinical hematology, 1946, Lea and Febiger, Philadelphia. Google Scholar9. WintrobeShumacker MMHS: Occurrence of macrocytic anemia in association with disorder of the liver, Bull. Johns Hopkins Hosp. 52: 387-407, 1933. Google Scholar10. BatemanShorrElgvin JMT: Hypervolemic anemia in cirrhosis, J. Clin. Investigation 38: 539-547, 1949. CrossrefGoogle Scholar11. MooreDoanArrowsmith CVCAWR: Studies in iron transportation and metabolism, J. Clin. Investigation 16: 627-648, 1937. CrossrefMedlineGoogle Scholar12. Broechner Mortensen K: Iron content of serum in patients with hemorrhagic anemia, Acta med. Scandinav. 113: 345, 1943. CrossrefGoogle Scholar13. HahnRossBaleWhipple PFJFWFGH: The utilization of iron and the rapidity of hemoglobin formation in anemia due to blood loss, J. Exper. Med. 71: 731-736, 1940. CrossrefMedlineGoogle Scholar14. Robscheit-RobbinsWhipple FSGH: Hemoglobin production increases with the severity of anemia, Am. J. Physiol. 134: 263-267, 1941. CrossrefGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Washington, D. C.*Received for publication August 2, 1949.From the New York University College of Medicine and Third Medical Division, Bellevue Hospital, New York, N. Y.Aided by a grant from the Dazian Foundation.†Now clinical instructor in medicine at George Washington University School of Medicine. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byEisenmangel und Eisenprophylaxe bei BlutspendernIron Deficiency and Treatment in Blood Donors Studied by the Iron Absorption Test 1 February 1951Volume 34, Issue 2Page: 393-400KeywordsAmino acidsAnemiaBlood donorsGlobinsHemoglobinHospital medicineLysineProteinsRegenerative medicine ePublished: 1 December 2008 Issue Published: 1 February 1951 PDF downloadLoading ...