Suramin and Function of the Adrenal Cortex
Authors: CY A. STEIN
Journal: Annals of Internal Medicine (1986)

Letters and Corrections1 February 1986Suramin and Function of the Adrenal CortexCY A. STEIN, M.D., Ph.D., WAYNE SAVILLE, B.S., ROBERT YARCHOAN, M.D., S. BRODER, M.D., EDWARD P. GELMANN, M.D.CY A. STEIN, M.D., Ph.D.Search for more papers by this author, WAYNE SAVILLE, B.S.Search for more papers by this author, ROBERT YARCHOAN, M.D.Search for more papers by this author, S. BRODER, M.D.Search for more papers by this author, EDWARD P. GELMANN, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-104-2-286_2 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: Suramin (Germanin, Bayer 205), the sodium salt of a sulfonated naphthyl polyurea, was initially introduced as a treatment for African trypanosomiasis. More recently, it has undergone clinical testing in patients with the acquired immunodeficiency syndrome (AIDS) (1) because of its ability to block the infectivity and cytopathic effect of the human T-lymphotropic virus type III/lymphadenopathy associated virus (2). We report an important apparent toxicity of suramin and describe the case of a patient with AIDS who developed profound hypoadrenalism after treatment with the drug.A 35-year-old white man with AIDS and Kaposi's sarcoma since 1982 had received...References1. BRODERYARCHOANCOLLINS SRJ. Effects of suramin on HTLV-III/LAV infection presenting as Kaposi's sarcoma or AIDS-related complex: clinical pharmacology and suppression of virus replication in vivo. Lancet. 1985;2:627-30. CrossrefMedlineGoogle Scholar2. MITSUYAPOPOVICYARCHOANMATSUSHITAGALLOBRODER MMRSRS. Suramin protection of T cells in vitro against infectivity and cytopathic effect of HTLV-III. Science. 1984;226:172-4. CrossrefMedlineGoogle Scholar3. HUMPHRIESDONALDSON EL. Degeneration of the adrenal cortex produced by germanin. Am J Pathol. 1941;17:767-75. MedlineGoogle Scholar4. FRISCHGARDNER EL. Failure of seramin (Bayer 205; Germanin) to cause changes in the adrenal cortex of the rat. Endocrinology. 1958;63:500-1. CrossrefMedlineGoogle Scholar5. TAPPERROTTERDAMLERNERAL'KHAFAJISEITZMAN MHCKP. Adrenal necrosis in the acquired immunodeficiency syndrome. Ann Intern Med. 1984;100:239-41. LinkGoogle Scholar6. GREENECOLEGREENE LWJ. Adrenal insufficiency as a complication of the acquired immunodeficiency syndrome. Ann Intern Med. 1984;101:497-8. LinkGoogle Scholar7. GUENTHNERRABINOWEVAN NIELNAFTILANDLUHY ESAAR. Primary Addison's disease in a patient with the acquired immunodeficiency syndrome. Ann Intern Med. 1984;100:847-8. LinkGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: National Cancer Institute Bethesda, MD 20892 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByAdrenal insufficiencyFixed higher dose schedule of suramin plus hydrocortisone in patients with hormone refractory prostate carcinomaAntiangiogenese: ein neuer Ansatz in der Tumortherapie?Mineralocorticoid insufficiency due to suramin therapyLack of effect of corticosteroids and tamoxifen on suramin protein binding and in vitro activityAntitumor activity of suramin in hormone-refractory prostate cancer controlling for hydrocortisone treatment and flutamide withdrawal as potentially confounding variablesMorphohistochemical relationships between adrenal cortex and major salivary glands in response to chronic suramin treatmentRole of nerve growth factor in suramin neurotoxicity studied in vitroSuramin decreases circulating levels of insulin-like growth factor-ISuramin: An inhibitor of the final steps of the mineralocorticoid pathway?The adrenal gland in AIDSEffects of suramin on the proliferation of primary epithelial cell cultures derived from normal, benign hyperplastic and cancerous human prostatesManagement of adrenal neoplasmsThe effects of suramin on human adrenocortical cells in vitro: Suramin inhibits cortisol secretion and adrenocortical cell growthAnthelminthic drugsChemical Stability of Suramin in Commonly used Infusion FluidsEffects of suramin on hormone release by cultured rat anterior pituitary cellsA Rapid Assay of Suramin in PlasmaA Rapid Isocratic HPLC Assay of Suramin (NSC 34936) in Human PlasmaEFFECT OF SURAMIN IN A PATIENT WITH ADRENOCORTICAL CARCINOMASuramin KeratopathyCorrection: Author's Name Omitted from Letter on Suramin 1 February 1986Volume 104, Issue 2Page: 286-287KeywordsAIDSAdrenal cortexAdverse reactionsHuman t lymphotropic virusKaposi sarcomaPatientsSaltsSodiumToxicityTrypanosomiasis Issue Published: 1 February 1986 PDF DownloadLoading ...