tbuckley/cabot-search huggingface dataset:
Improvement in outcome for children receiving allogeneic bone marrow transplantation in first remission of acute myeloid leukemia: a report from the Groupe d'Etude des Greffes de Moelle Osseuse.
Authors: G Michel, E Gluckman, D Blaise, H Esperou-Bourdeau, J P Vernant, M Kuentz, P Bordigoni, N Milpied, H Rubie, I Thuret
Journal: Journal of Clinical Oncology (1992)

PURPOSE We retrospectively analyzed the outcome of children with acute myeloid leukemia (AML) in first complete remission (CR) who received HLA-identical bone marrow transplantation (BMT) in 13 French transplant centers. PATIENTS AND METHODS Seventy-four children were treated from June 1979 through December 1990. The conditioning regimen included total-body irradiation (TBI) in 54 cases and busulfan in 20. Prophylaxis of graft-versus-host disease (GVHD) consisted of cyclosporine (CycloA) plus methotrexate (MTX) for 38 patients, MTX for 17, CycloA for 18, and T depletion without other prophylaxis for one. The mean value of the interval from diagnosis to transplantation was 167 days. RESULTS Sixteen patients died of transplant-related complications, 12 relapsed, and 46 are alive in continuous remission with a median follow-up of 46 months. We examined results obtained over three successive periods: 1979 to 1982 (n = 14 children), 1983 to 1986 (n = 29), and 1987 to 1990 (n = 31). Probabilities of event-free survival (EFS) were 43%, 48%, and 82% for the three successive periods, respectively (P &lt; .02). This improvement in EFS was linked to a decreased risk of transplant-related mortality: 36%, 36%, and 3%, respectively (P &lt; .01). Other factors associated with a better EFS in the univariate analysis were a short time interval from diagnosis to transplant (&lt; 120 days), the absence of significant (grade &gt; or = 2) acute GVHD, and the absence of chronic GVHD. In the multivariate analysis, two factors had a favorable impact on long-term survival: the year of transplantation (years 1987 to 1990 v others) and the absence of acute GVHD. CONCLUSION The outcome for children receiving allogeneic BMT in first CR of AML has improved in France during recent years.
Can We Predict Radiation-Induced Changes in Pulmonary Function Based on the Sum of Predicted Regional Dysfunction?
Authors: Ming Fan, Lawrence B. Marks, Donna Hollis, Gunilla G. Bentel, Mitchell S. Anscher, Gregory Sibley, R. Edward Coleman, Ronald J. Jaszczak, Michael T. Munley
Journal: Journal of Clinical Oncology (2001)

PURPOSE: To determine whether changes in whole-lung pulmonary function test (PFT) values are related to the sum of predicted radiation therapy (RT)-induced changes in regional lung perfusion. PATIENTS AND METHODS: Between 1991 and 1998, 96 patients (61% with lung cancer) who were receiving incidental partial lung irradiation were studied prospectively. The patients were assessed with pre- and post-RT PFTs (forced expiratory volume in one second [FEV 1 ] and diffusion capacity for carbon monoxide [DLCO]) for at least a 6-month follow-up period, and patients were excluded if it was determined that intrathoracic recurrence had an impact on lung function. The maximal declines in PFT values were noted. A dose-response model based on RT-induced reduction in regional perfusion (function) was used to predict regional dysfunction. The predicted decline in pulmonary function was calculated as the weighted sum of the predicted regional injuries: equation [Formula: see text] where V d is the volume of lung irradiated to dose d, and R d is the reduction in regional perfusion anticipated at dose d. RESULTS: The relationship between the predicted and measured reduction in PFT values was significant for uncorrected DLCO (P = .005) and borderline significant for DLCO (P = .06) and FEV 1 (P = .08). However, the correlation coefficients were small (range, .18 to .30). In patients with lung cancer, the correlation coefficients improved as the number of follow-up evaluations increased (range, .43 to .60), especially when patients with hypoperfusion in the lung adjacent to a central mediastinal/hilar thoracic mass were excluded (range, .59 to .91). CONCLUSION: The sum of predicted RT-induced changes in regional perfusion is related to RT-induced changes in pulmonary function. In many patients, however, the percentage of variation explained is small, which renders accurate predictions difficult.
Simple methods for estimating the numbers of synonymous and nonsynonymous nucleotide substitutions.
Authors: M Nei, T Gojobori
Journal: Molecular Biology and Evolution (1986)

Two simple methods for estimating the numbers of synonymous and nonsynonymous nucleotide substitutions are presented. Although they give no weights to different types of codon substitutions, these methods give essentially the same results as those obtained by Miyata and Yasunaga's and by Li et al.'s methods. Computer simulation indicates that estimates of synonymous substitutions obtained by the two methods are quite accurate unless the number of nucleotide substitutions per site is very large. It is shown that all available methods tend to give an underestimate of the number of nonsynonymous substitutions when the number is large.
A multicentre comparative prospective blinded analysis of EUS and MRI for screening of pancreatic cancer in high-risk individuals
Authors: F Harinck, I C A W Konings, I Kluijt, J W Poley, J E van Hooft, H M van Dullemen, C Y Nio, N C Krak, J J Hermans, C M Aalfs, A Wagner, R H Sijmons, K Biermann, C H van Eijck, D J Gouma, M G W Dijkgraaf, P Fockens, M J Bruno
Journal: Gut (2015)

<h3>Objective</h3> Endoscopic ultrasonography (EUS) and MRI are promising tests to detect precursors and early-stage pancreatic ductal adenocarcinoma (PDAC) in high-risk individuals (HRIs). It is unclear which screening technique is to be preferred. We aimed to compare the efficacy of EUS and MRI in their ability to detect clinically relevant lesions in HRI. <h3>Design</h3> Multicentre prospective study. The results of 139 asymptomatic HRI (&gt;10-fold increased risk) undergoing first-time screening by EUS and MRI are described. Clinically relevant lesions were defined as solid lesions, main duct intraductal papillary mucinous neoplasms and cysts ≥10 mm. Results were compared in a blinded, independent fashion. <h3>Results</h3> Two solid lesions (mean size 9 mm) and nine cysts ≥10 mm (mean size 17 mm) were detected in nine HRI (6%). Both solid lesions were detected by EUS only and proved to be a stage I PDAC and a multifocal pancreatic intraepithelial neoplasia 2. Of the nine cysts ≥10 mm, six were detected by both imaging techniques and three were detected by MRI only. The agreement between EUS and MRI for the detection of clinically relevant lesions was 55%. Of these clinically relevant lesions detected by both techniques, there was a good agreement for location and size. <h3>Conclusions</h3> EUS and/or MRI detected clinically relevant pancreatic lesions in 6% of HRI. Both imaging techniques were complementary rather than interchangeable: contrary to EUS, MRI was found to be very sensitive for the detection of cystic lesions of any size; MRI, however, might have some important limitations with regard to the timely detection of solid lesions.
Efficacy of Dantrolene Sodium in Management of Tetanus in Children
Authors: O R Aguilar Bernal, M A Bender, ME Lacy
Journal: Journal of the Royal Society of Medicine (1986)

The effectiveness of dantrolene sodium in controlling tetanic spasms was evaluated in 21 children (aged 4 days-13 years) with tetanus. These dantrolene-treated patients were compared with an historical control group of 26 children previously treated for tetanus by traditional means at the same institution. The groups were comparable in terms of age, other treatments, and severity of disease. All patients received standard treatments for tetanus, including sedatives, antibiotics, and tetanus-immune globulin. Patients in the dantrolene-treated group also received dantrolene, either intravenously (Dantrium® Intravenous) or orally, in divided doses totalling 4–6 mg/kg/day. Mortality was 73% (neonates 83%, non-neonates 50%) in the control group, compared with 33% (neonates 50%, non-neonates 0%) in the dantrolene-treated group. Dantrolene did not cause additional respiratory depression when administered alone or in combination with other drugs routinely used to treat tetanus. In this study, the use of dantrolene with traditional conservative therapy significantly reduced mortality from tetanus.
The effects of beta-blocker therapy on systolic and diastolic function in pulmonary arterial hypertension: A randomized controlled trial
Authors: Jasmijn van Campen, Cathelijne van der Brugeen, Pia Trip, Karin de Boer, Cor Allaart, Louis Handoko, Frances de Man, Harm Jan Bogaard, Anton Vonk Noordegraaf
Journal: European Respiratory Journal (2014)

Experimental studies have suggested potential benefit of beta-blocker therapy in pulmonary arterial hypertension (PAH). Here, we describe the effects of beta-blocker therapy on load-independent measures of RV function.

18 patients with optimally treated, stable iPAH (9/9 NYHA II/III ) were included in a double blind, placebo controlled cross-over trial assessing the safety and efficacy of bisoprolol. ([NCT01246037][1])

An average dose of 4.4±3.2 mg (0-10mg) bisoprolol and 2.7±1.4 tablets placebo was achieved. 5 serious adverse events were reported. One was associated with bisoprolol usage: fluid retention wherefore treatment with iv diuretics was needed. 2/18 patients didn't tolerate bisoprolol.

The primary endpoint of the study is right ventricular ejection fraction (RVEF). The two patients whit Raynaud's syndrome at inclusion, were diagnosed with limited scleroderma (LS) during the study. They showed a severe drop in RVEF of 16% and 21% after treatment. This was reason to also perform a subgroup analysis(table 1).

![Figure][2] 



Conclusions 

-In i-PAH beta-blocker therapy is safe and is tolerated.

-There were no significant changes in systolic or diastolic function.

-The subgroup analysis of the patients with LS showed a significant deterioration of RVEF, exercise capacity and RV-arterial uncoupling.

-The subgroup analysis of the patients without LS showed a significant improvement of RVEF and Ees/Ea.

 [1]: /lookup/external-ref?link_type=CLINTRIALGOV&access_num=NCT01246037&atom=%2Ferj%2F44%2FSuppl_58%2F3422.atom
 [2]: pending:yes
Thoracoplasty in the treatment of chronic nonspecific empyema
Authors: Serhiy Koshak, Oleksander Beliak, Orest Petryshyn, Mykhaylo Sekela
Journal: European Respiratory Journal (2012)

Background/Objctives: Problems in the treatment of chronic nonspecific empyema of pleura (CNEP) remain relevant.  Material and Methods: 207 patients were treated with CNEP in clinics of Lviv Regional Center of Phthisiology and Pulmonology and Lviv Regional Hospital at the past 30 years, aged 15 - 80 years from 1.5 month to 13 years from the date of diagnosed acute suppuration pleura. Results: Reasons CNEP: purulent inflammation of the lungs with bronhopleural fistula and residual pleural cavity were found in 125 (60.38%) patients; suppuration of hemathorax - in 28 (13.53%), suppuration of pleural effusion - in 22 (10.64%); complications after surgery - in 24 (11.59%), pleural cavity foreign body - in 8 (3.86%). An operations: dekortykation with resection and lung and pleura were performed in 95 cases, including lob -, bilobektomy - in 23; atypical segmentektomy - in 16; pleuropulmonektomy - in 7, taking in bronchial fistulas - in 17. If you have problems with smoothing out the lung, intrapleural thoracoplasty operation completed (47 cases). In 4 patients with significantly reduced spirometry and hasmetry was performed ekstrapleural thoracoplasty. In the postoperative period died 6 (2.89%) patients. After thoracoplasty all patients survived. Conclusion: We believe that the most appropriate and economically justified in patients with radical resection is CNEP lungs and pleura. Nonaccordance volume of lung and pleural cavity requires plastic chest wall.
Alarming carboxyhemoglobin and nicotine levels after a single session of indoor group narghile smoking
Authors: Lea Bentur, Elias Hellou Hellou, Aviv Goldbart, Giora Piller, Einat Monovich, Maram Salameh, Yedidia Bentur
Journal: European Respiratory Journal (2013)

Introduction:  Group indoor water pipe smoking (WPS), especially in coffee shops, has become increasingly popula.   Objectives :Evaluation of the effect of a single session of indoor WPS on carboxyhemoglobin (COHb), nicotine, and cotinine concentrations; exhaled breath condensate (EBC) cytokines; endothelial function; cardio-respiratory parameters; and clinical assessment in active and passive WPS.   Design:  Prospective study evaluating outcome parameters before and after 30 minutes of WPS.   Statistics:  Paired and non-paired Student9s  t -test, Wilcoxon test, Fisher exact test, ANOVA, and Neuman–Keuls where relevant.   Results:  Sixty-two volunteers (47 active;15 passive smokers). Post-WPS there was an alarming increase in COHb (2.0±2.9  vs. 17.6±8.8),Plasma nicotine increased significantly (1.2±4.3  vs .18.8±13.9 ng/mL) and was associated with increase in plasma cotinine and increase in urinary nicotine and cotinine. Exhaled breath condensate revealed significant decrease in IL4, IL5, IL10, IL17, and gamma interferon. Endothelial function did not change after smoking. These were associated with changes of multiple cardio-respiratory parameters, decreased visual analog score of general feeling, and multiple clinical symptoms. In passive smokers carboxyhemoglobin increased (0.8±0.25  vs.  1.2±0.8%,  p =0.003); increased respiratory rate and decline in visual analog score.   Conclusions:  One session of group indoor active WPS resulted in significant increases in COHband serum nicotine levels (8- and 18-fold, respectively) and was associated with cardio-respiratory changes. The results of our call for interventions to limit the continuing global spread of coffee shops and bars.
Comparison of respiratory muscle recruitments between maximal voluntary contraction and strenuous exercise
Authors: Pauliane Santana, Leticia Cardenas, Renata Pletsch, Jeferson Ferreira, Luiz Orlandim, Albuquerque Andre, Carvalho Carlos, Patricia Trevizan, Renan Maloni, Pedro Caruso
Journal: European Respiratory Journal (2013)

Rationale : the measurement of muscle recruitment induced by maximal voluntary contraction (MVC) is indispensable to normalize electromyographic(EMG) signals and to evaluate muscle recruitment during the exercise or disease. However for the respiratory muscles the MVC maneuvers are not established.  Objective : to compare the respiratory muscle recruitment induced by MVC maneuvers with the recruitment induced by strenuous exercise.  Method : In 14 healthy volunteers, first we evaluated the superficial EMG during a MVC of the scalene (deep inspiration concomitant with side bending of the neck against a resistance), sternomastoid (head rotation against a resistance), paraesternal intercostal (deep inspiration) and external oblique (Valsalva maneuver while rising from a chair against a resistance). Then we evaluated the same muscles during an incremental cycling exercise until exhaustion.  Results : For the scalene and sternomastoid, the EMG signal during MVC was significantly higher than during exercise (p Conclusion : The MVC maneuvers used to evaluate the scalene and sternomastoid may represent a real maximal contraction, but not the external oblique and especially the paraesternal intercostal maneuvers.
Abstract 1064: Factors Influencing the Use of Higher-Tech/Higher Cost Implantable Cardioverter-Defibrillators: Data From the NCDR ICD Registry
Authors: Rachel J Lampert, Yongfei Wang, Jeptha Curtis
Journal: Circulation (2009)

Introduction: New ICD models are regularly introduced, incorporating technological advantages. The factors associated with use of these higher-tech/higher cost devices as opposed to older models ha...
Capecitabine (Xeloda) and quality of life (QoL) in patients (pts) with metastatic breast cancer (MBC) relapsing after treatment with anthracycline and taxane containing–therapy
Authors: D. Grecea Sr., L. Neamtiu, C. Vasiliniuc, R. Tanasescu, A. Rancea, L. Resiga, M. Galatar, V. Popita, D. Daicoviciu, D. Postescu, N. Ghilezan
Journal: Journal of Clinical Oncology (2006)

10774 Background: The study was designed to evaluate further the efficacy and safety of capecitabine in patients with MBC previously treated with antracycline and taxane. In addition to response rates and survival times, pts preference for oral therapy and QoL are increasingly important considerations in MBC. Methods: All MBC patients had to have documented progression after antracycline and taxane- containing chemotherapy in neoadjuvant or adjuvant setting, no more than one line for MBC. Treatement comprised 3-week cycles of oral capecitabine 1250 mg/m 2 twice- daily for 14 days followed by a 7-day rest period. Results: From December 2002 to November 2005, 35 pts were enrolled. Baseline characteristics of the pts. were: median age 51 years (range 33–73), median ECOG PS 1 (range 0–2) and adequate bone marrow, renal and hepatic functions. Median number of metastatic sites was 2 (range 1–5). The pts were evaluable for response and toxicity and received a total of 162 cycles of chemotherapy. Disease stabilization occurred in 11 pts (31.4%), the overall response was 34.2%, ten pts (28.5%) achieved a partial response, two patients (5.7%) achieved a complete response. Median duration of response was 5 months and median overall survival was 8 months with significant advantage for responding patients. For pts achieving a CR or PR, median survival was 13 months, for SD 10 months and for pts with PD as best response 5 months. The most treatment-related adverse events were grade 1/2 in intensity: grade 3 treatment-related adverse events were hand-foot syndrome (11%), diarrhea (7%), vomiting (5%), and nausea (6%). Pts had a significant, sustained improvement in the following: global health status, role and emotional functioning, social functioning, breast symptoms, arm symptoms and hair loss. Conclusions: This study confirms that capecitabine achieves a high tumor control rate in heavily pretreated MBC pts. Pts had a significant improvement in global health status, with substantial improvements in almost all functional and symptomatic QoL domains. Capecitabine should be considered the reference treatment in this setting based on consistently high efficacy and good tolerability. No significant financial relationships to disclose.
Wide geographic variations of sensitivity to MOTT sensitins in Greece
Authors: G A Dascalopoulos, S Loukas, S H Constantopoulos
Journal: European Respiratory Journal (1995)

Several studies have suggested that large bodies of water are a main source of infection with mycobacteria other than tuberculosis (MOTT). If this is correct, there should be a gradient in the infection rate with MOTT between mountainous and seaside areas. To test this hypothesis, we performed skin testing with tuberculin and sensitins in 19,470 Greek Armed Forces recruits. Initially, several MOTT sensitins were used, but when it became clear that the Mycobacterium scrofulaceum sensitin was the most appropriate, the study was continued with it alone in 17,403 recruits. Finally, in order to evaluate the geographical distribution of sensitivity to sensitins, we studied the results of 8,507 of these recruits living in or near their birthplace. They were divided into three geophysical areas: seaside 3,389 recruits; mountains 2,692 recruits; and inland plains 2,426 recruits. MOTT sensitivity rates were 4.1% in mountainous areas and 7.1% in seaside areas. All small Aegean islands had high MOTT rates (above 8%). In inland plains, high MOTT rates (above 8%) were observed among those living near big rivers. This geographical distribution of MOTT sensitivity supports the theory that large bodies of water are a main source of infection with MOTT.
Genetic errors of the human caspase recruitment domain–B-cell lymphoma 10–mucosa-associated lymphoid tissue lymphoma-translocation gene 1 (CBM) complex: Molecular, immunologic, and clinical heterogeneity
Authors: Rebeca Pérez de Diego, Silvia Sánchez-Ramón, Eduardo López-Collazo, Rubén Martínez-Barricarte, Carolina Cubillos-Zapata, Antonio Ferreira Cerdán, Jean-Laurent Casanova, Anne Puel
Journal: Journal of Allergy and Clinical Immunology (2015)
Autoantibody production from a thymoma and a follicular dendritic cell sarcoma associated with paraneoplastic pemphigus
Authors: J. Wang, D.F. Bu, T. Li, R. Zheng, B.X. Zhang, X.X. Chen, X.J. Zhu
Journal: British Journal of Dermatology (2005)

Journal Article Autoantibody production from a thymoma and a follicular dendritic cell sarcoma associated with paraneoplastic pemphigus Get access J. Wang, J. Wang Departments of Dermatology and Pathology, Peking University First Hospital, 8 Xishiku St, Beijing 100034, China Search for other works by this author on: Oxford Academic Google Scholar D.F. Bu, D.F. Bu Departments of Dermatology and Pathology, Peking University First Hospital, 8 Xishiku St, Beijing 100034, China Search for other works by this author on: Oxford Academic Google Scholar T. Li, T. Li Departments of Dermatology and Pathology, Peking University First Hospital, 8 Xishiku St, Beijing 100034, China Search for other works by this author on: Oxford Academic Google Scholar R. Zheng, R. Zheng Departments of Dermatology and Pathology, Peking University First Hospital, 8 Xishiku St, Beijing 100034, China Search for other works by this author on: Oxford Academic Google Scholar B.X. Zhang, B.X. Zhang Departments of Dermatology and Pathology, Peking University First Hospital, 8 Xishiku St, Beijing 100034, China Search for other works by this author on: Oxford Academic Google Scholar X.X. Chen, X.X. Chen Departments of Dermatology and Pathology, Peking University First Hospital, 8 Xishiku St, Beijing 100034, China Search for other works by this author on: Oxford Academic Google Scholar X.J. Zhu X.J. Zhu Departments of Dermatology and Pathology, Peking University First Hospital, 8 Xishiku St, Beijing 100034, China Xuejun Zhu. E‐mail: zhuxj@public.bta.net.cn Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 153, Issue 3, 1 September 2005, Pages 558–564, https://doi.org/10.1111/j.1365-2133.2005.06599.x Published: 01 September 2005 Article history Accepted: 18 December 2004 Published: 01 September 2005
The effectiveness of carrying out 6 month and 1 year re-assessments for respiratory patients post pulmonary rehabilitation
Authors: Lynsey Wright, Laura Cornish, Julie Tollit, Laura Webb, Fran Dyer, Julia Bott
Journal: European Respiratory Journal (2012)

Introduction:   Pulmonary Rehabilitation (PR) Re-assessment groups are offered at 6 months and 1 year post completion of PR. The purpose is to review patients current health status, monitor exercise tolerance, mood and quality of life and check compliance with self management skills taught in PR   Aim:   To determine the level of attendance at 6 months and 1 year re-assessments in order to establish whether this is an effective method of review, both for the patient and Community Respiratory Team.   Method:   All patients who completed PR were invited to re-assessments at 6 months and 1 year post PR. The number of patients who attended were recorded.   Results:   262 patients completed PR between January 2009 and December 2012.  40 patients were excluded from assessments and analysis at the 6 months re-assessments due to staff shortages and severe weather. 13 patients (6 at 6 months and 7 at 1 year) had died and also excluded.   Conclusion:   These data indicate a drop of 23% in attendance at the 1 year reassessment from 6 months, therefore suggesting this may not be the most effective method of review and furthermore provides reasonable evidence to support a re-evaluation of the 1 year re-assessment. There is cause to ensure review of those not attending reassessments as they are at high risk of poor self management and the ongoing review method of these patients needs further consideration.