THE MECHANISM OF RECOVERY IN ACUTE BACTERIAL PNEUMONIA
Authors: W B WOOD
Journal: Annals of Internal Medicine (1947)

Article1 September 1947THE MECHANISM OF RECOVERY IN ACUTE BACTERIAL PNEUMONIAW. BARRY WOOD JR., F.A.C.P.W. BARRY WOOD JR., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-27-3-347 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptAlthough the treatment of acute bacterial pneumonia has been revolutionized in recent years by the advent of chemotherapy, the exact mechanism of recovery is not known. Pertinent to the problem are the following basic facts:1. Most of the bacteria that cause the more common forms of acute pneumonia are encapsulated (pneumococcus, beta hemolytic streptococcus, Friedländer's bacillus, influenza bacillus, staphylococcus), and the presence of the capsules renders the organisms resistant to phagocytosis.1 According to present concepts of immunology, fully encapsulated microörganisms can be phagocyted only in the presence of suitable opsonins.22. Sulfonamide drugs that are highly effective in the...Bibliography1. DUBOS RJ: The bacterial cell, 1945, Harvard University Press, Cambridge, p. 205. Google Scholar2. ZINSSERENDERSFOTHERGILL HJFL: Immunity, principles and application in medicine and public health, 1939, MacMillan Co., New York, p. 18. Google Scholar3. FINLANDSPRINGLOWELL MWCFC: Studies on the action of sulfapyridine on pneumococci, Jr. Clin. Invest., 1940, xix, 163. Google Scholar4. TILLETCAMBIERMCCORMACK WSMJJE: The treatment of lobar pneumonia and pneumococcal empyema with penicillin, Bull. N. Y. Acad. Med., 1944, xx, 142. Google Scholar5. FINLANDMEADSORY MMEM: Oral penicillin, Jr. Am. Med. Assoc., 1945, cxxix, 315. CrossrefGoogle Scholar6. HEILMANHERRELL DHWE: Comparative antibacterial activity of penicillin and gramicidin: tissue culture studies, Proc. Staff Meet. Mayo Clin., 1942, xvii, 321. Google Scholar7. WOODIRONS WBEN: Studies on the mechanism of recovery in pneumococcal pneumonia, Jr. Exper. Med., 1946, lxxxiv, 365. CrossrefGoogle Scholar8. WOODLONG WBPH: Observations upon the experimental and clinical use of sulfapyridine, Ann. Int. Med., 1939, xiii, 612. Google Scholar9. FINLANDSPRINGLOWELL MWCFC: Immunological studies on patients with pneumococcic pneumonia treated with sulfapyridine, Jr. Clin. Invest., 1940, xix, 179. CrossrefGoogle Scholar10. WOODMCLEODIRONS WBCEN: Studies on the mechanism of recovery in pneumococcal pneumonia, Jr. Exper. Med., 1946, lxxxiv, 377. CrossrefGoogle Scholar11. ROBERTSON OH: Some recent studies of experimental lobar pneumonia: pathogenesis, recovery and immunity, Jr. Am. Med. Assoc., 1938, cxi, 1432. CrossrefGoogle Scholar12. GUNNNUNGESTER FDWJ: Pathogenesis and histopathology of experimental pneumonia in rats, Arch. Path., 1936, xxi, 813. Google Scholar13. WOOD WB: Studies on the mechanism of recovery in pneumococcal pneumonia, Jr. Exper. Med., 1941, lxxiii, 201. CrossrefGoogle Scholar14. LOOSLI CG: The pathogenesis and pathology of experimental Type I pneumococcic pneumonia in the monkey, Jr. Exper. Med., 1942, lxxvi, 79. CrossrefGoogle Scholar15. SALEWOOD LWB: Studies on the mechanism of recovery in pneumonia due to Friedländer's bacillus. I. The pathogenesis of experimental Friedländer's bacillus pneumonia. In press. Google Scholar16. BLACKCECIL FGRL: Studies on experimental pneumonia, Jr. Exper. Med., 1920, xxxi, 445. Google Scholar17. PERMAR HH: The pathogenesis of experimental pneumonia in the rabbit, Jr. Med. Res., 1923, xli, 1. Google Scholar18. BRANCHSTILLMAN AEG: Pathology of experimental pneumococcus pneumonia in mice, Jr. Exper. Med., 1924, xl, 743. CrossrefGoogle Scholar19. ROBERTSONHAMBURGER OHM: Studies on the pathogenesis of experimental pneumococcus pneumonia in the dog, Jr. Exper. Med., 1940, lxxii, 275. CrossrefGoogle Scholar20. ROBERTSON OH: Phagocytosis of foreign material in the lung, Physiol. Rev., 1941, xxi, 112. CrossrefGoogle Scholar21. YOUNGZELBELINCOLN GAMRRE: Respiratory pathogenicity of Bacillus anthracis spores, Jr. Infect. Dis., 1946, lxxix, 233. CrossrefGoogle Scholar22. LOOSLI CG: Personal communication. Google Scholar23. SCHULZWARRENDRINKER RZMFCL: The passage of rabbit virulent Type III pneumococci from the respiratory tract of rabbits into the lymphatics and blood, Jr. Exper. Med., 1938, lxviii, 251. CrossrefGoogle Scholar24. MILLER WS: The lung, 1937, Charles C. Thomas, Baltimore, p. 108. Google Scholar25. LOESCHCKE H: Untersuchungen über die Kruppöse Pneumonie, Beitr. z. path. Anat. u. z. allg. Path., 1931, lxxxvi, 201. Google Scholar26. NYEHARRIS RNAH: Viable pneumococci and pneumococcic specific soluble substances in the lungs from cases of lobar pneumonia, Am. Jr. Path., 1937, xiii, 749. Google Scholar27. SALESMITHWOOD LMRWB: Studies on the mechanism of recovery in pneumonia due to Friedländer's bacillus. II. The effect of sulfonamide chemotherapy upon the pulmonary lesion of experimental Friedländer's bacillus pneumonia. In press. Google Scholar28. WOODSMITHWATSON WBMRB: Studies on the mechanism of recovery in pneumococcal pneumonia, Jr. Exper. Med., 1946, lxxxiv, 387. CrossrefGoogle Scholar29. WOODSMITH WBMR: To be published. Google Scholar30. WOODSMITH WBMR: Intercellular surface phagocytosis. In press. Google Scholar31. SMITHWOOD MRWB: Studies on the mechanism of recovery in pneumonia due to Friedländer's bacillus. III. The rôle of "surface phagocytosis" in the destruction of the microörganisms in the lung. In press. Google Scholar32. DRINKERYOFFE CKJM: Lymphatics, lymph and lymphoid tissue, 1941, Harvard University Press, Cambridge, p. 170. Google Scholar33. BEESONBRANNONWARREN PBESJV: Observations on the sites of removal of bacteria from the blood in patients with bacterial endocarditis, Jr. Exper. Med., 1945, lxxxi, 9. CrossrefGoogle Scholar34. TILLETMCCORMACKCAMBIER WSJEM: The use of penicillin in the local treatment of pneumococcal empyema, Jr. Clin. Invest., 1945, xxiv, 595. CrossrefGoogle Scholar35. KEEFERBLAKEMARSHALLLOCKWOODWOOD CSFGEKJSWB: Penicillin in the treatment of infections, Jr. Am. Med. Assoc., 1943, cxxii, 1217. CrossrefGoogle Scholar36. SMITHWOOD MRWB: Unpublished observations. Google Scholar37. ROBERTSONGRAESERCOGGESHALLHARRISON OHJBLTMA: The relation of circulating antipneumococcal immune substances to the course of lobar pneumonia, Jr. Clin. Invest., 1934, xiii, 621. CrossrefGoogle Scholar38. CURNENMACLEOD ECCM: The effect of sulfapyridine upon the development of immunity to pneumococcus in rabbits, Jr. Exper. Med., 1942, lxxv, 77. CrossrefGoogle Scholar39. WOODSMITH WBMR: Surface phagocytosis—its relation to the mechanism of recovery in pneumococcal pneumonia, Science, 1946, civ, 28. CrossrefGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: St. Louis, Missouri*Presented before the Twenty-Eighth Annual Session of the American College of Physicians, Chicago, Illinois, April 29, 1947.From the Department of Medicine and the Oscar Johnson Institute for Medical Research, Washington University School of Medicine, St. Louis, Missouri. The experimental studies were supported by a grant from the Commonwealth Fund.†When injected locally in sufficient concentration, penicillin is bactericidal.6 Nextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byBacterien-haemagglutinationCORTISONE AND INFECTIONRelation of Surface Phagocytosis to the Fibrinous Character of Acute Bacterial ExudatesRelation of Surface Phagocytosis to the Fibrinous Character of Acute Bacterial Exudates 1 September 1947Volume 27, Issue 3Page: 347-352KeywordsBacillusBacterial pneumoniaDrugsImmunologyPenicillinPneumococcusPneumoniaStaphylococcusStreptococcusSulfonamide ePublished: 1 December 2008 Issue Published: 1 September 1947 Copyright & PermissionsCopyright, 1947, by The American College of PhysiciansPDF downloadLoading ...