Glucose Tolerance, Plasma Insulin, and Free Fatty Acids in Elderly Subjects
Authors: ROBERT METZ
Journal: Annals of Internal Medicine (1966)

Article1 May 1966Glucose Tolerance, Plasma Insulin, and Free Fatty Acids in Elderly SubjectsROBERT METZ, M.B., PH.D., BARBARA SURMACZYNSKA, M.D., SHELDON BERGER, M.D., GERALD SOBEL, M.D.ROBERT METZ, M.B., PH.D.Search for more papers by this author, BARBARA SURMACZYNSKA, M.D.Search for more papers by this author, SHELDON BERGER, M.D.Search for more papers by this author, GERALD SOBEL, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-64-5-1042 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe older an individual on whom a glucose tolerance test is performed, the more likely will the result be abnormal, as judged by standard criteria (1-9). The evidence suggests that this trend intensifies sharply in the seventh decade of life, so much so that questions arise as to the interpretation of glucose tolerance tests in elderly individuals. More fundamental questions relate to the mechanism of the age-related change in blood glucose homeostasis. The elucidation of this phenomenon might well have important theoretical and practical implications for our understanding of both diabetes and aging.The objective of the present study was...References1. WESTWULFREIGELFITZGERALD KMJADGDT: Oral carbohydrate tolerance tests. Arch. Intern. Med. (Chicago) 113: 641, 1964. CrossrefMedlineGoogle Scholar2. CHESROWBLEYER EJJM: The glucose tolerance test on the aged. Geriatrics 9: 276, 1954. MedlineGoogle Scholar3. PORTERLANGLEY EGJ: Studies in blood sugar. Lancet 2: 947, 1926. CrossrefGoogle Scholar4. SPENCE JC: Some observations on sugar tolerance with special reference to variations found at different ages. Quart. J. Med. 14: 314, 1921. CrossrefGoogle Scholar5. SILVERSTONEBRANDFONBRENERSHOCKYIENGST FAMNWMJ: Age differences in the intravenous glucose tolerance tests and the response to insulin. J. Clin. Invest. 36: 504, 1957. 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Plasma insulin levels of normal, subdiabetic and diabetic rats. Diabetes 12: 115, 1963. CrossrefGoogle Scholar13. ZALMEKNOWLES EHC: A plea for plasma sugar. Diabetes 14: 165, 1965. CrossrefMedlineGoogle Scholar14. YALOWBERSON RSSA: Immunoassay of plasma insulin in man. Diabetes 10: 339, 1961. CrossrefMedlineGoogle Scholar15. POWERREYES-LEALCONN LBJW: Serum insulin-like activity in genetic and experimental diabetes mellitus. Metabolism 13: 1297, 1964. CrossrefMedlineGoogle Scholar16. WERKKNOWLES EEHC: The blood ketone and plasma free fatty acid concentration in diabetic and normal subjects. Diabetes 10: 22, 1961. CrossrefMedlineGoogle Scholar17. SHAFRIRGUTMAN EA: Patterns of decrease of free fatty acids during glucose tolerance tests. Diabetes 14: 77, 1965. CrossrefMedlineGoogle Scholar18. KIPNISSTEIN DMM: Insulin antagonism: fundamental considerations, in Aetiology of Diabetes Mellitus and its Complications, edited by CAMERON, M. P., O'CONNOR, M. Little, Brown and Co., Boston, 1964, p. 156. CrossrefGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Chicago, IllinoisFrom the Department of Medicine, Northwestern University Medical School, Chicago, Ill.Requests for reprints should be addressed to Robert Metz, M.B., Department of Medicine, Northwestern University Medical School, 303 E. Chicago Ave., Chicago, Ill. 60611. 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A five-year experiencePROBLEMS AND PROGRESS IN GERIATRICS*Acceptability of Vegetables in an Army Mess1 1 May 1966Volume 64, Issue 5Page: 1042-1048KeywordsAgingBloodBlood plasmaElderlyFatty acidsGlucoseGlucose toleranceGlucose tolerance testsIngestionInsulin Issue Published: 1 May 1966 PDF downloadLoading ...