AN EXPLANATION OF THE MECHANISM OF INFANTILE PARALYSIS PRODUCTION IN THE HUMAN BEING
Authors: John A. Toomey
Journal: Annals of Internal Medicine (1935)

Article1 January 1935AN EXPLANATION OF THE MECHANISM OF INFANTILE PARALYSIS PRODUCTION IN THE HUMAN BEINGJOHN A. TOOMEY, M.D., F.A.C.P.JOHN A. TOOMEY, M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-8-7-854 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptPART IFaber1believed that a good theory for the explanation of the virus spread in poliomyelitis in man would be to assume that, after the virus entered the system along the olfactory terminal fibers, it spread by way of the olfactory tracts, through the hypothalamus, to the medulla, thalamus and midbrain, and then down the spinothalamic tract to the posterior column, finally reaching the anterior horn cell area in the cord. However, the possibility of extension by other pathways was not denied. His hypothesis was based upon clinical findings and upon evidence that was obtained from experiments on monkeys...Bibliography1. FABER HK: Acute poliomyelitis as a primary disease of the central nervous system, Medicine, 1933, xii, 83-186. CrossrefGoogle Scholar2. FLEXNER S: Some problems in infection and its control, Science, 1912, xxxvi, 685-702. CrossrefGoogle Scholar3. FLEXNERLEWIS SPA: Experimental poliomyelitis in monkeys, Jr. Am. Med. Assoc., 1910, liv, 1780-1782. CrossrefGoogle Scholar4. BROOKOVER C: The peripheral distribution of the nervus terminalis in an infant, Jr. Comp. Neurol., 1917, xxviii, 349-360. CrossrefGoogle Scholar5. HUBERGUILD GCSR: Observations on the peripheral distribution of the nervus terminalis in mammalia, Anat. Rec., 1913, vii, 253-272. (Cited by Brookover.4) CrossrefGoogle Scholar6. FAIRBROTHERHURST RWEW: The pathogenesis of, and propagation of the virus in, experimental poliomyelitis, Jr. Path. and Bact., 1930, xxxiii, 17-45. CrossrefGoogle Scholar7. HURST EW: A further contribution to the pathogenesis of experimental poliomyelitis: inoculation into the sciatic nerve, Jr. Path. and Bact., 1930, xxxiii, 1133-1143. CrossrefGoogle Scholar8. TOOMEY JA: Spread of poliomyelitis virus along nerve fibers of the sympathetic system, Proc. Soc. Exper. Biol. and Med., 1934, xxxi, 502-505. CrossrefGoogle Scholar9. LANDSTEINERPOPPER KE: Mikroscopische Präparate von einem menschlichen und zwei Affenrückenmarken, Wien. klin. Wchnschr., 1908, xi, 1830. Google Scholar10. LEVADITILANDSTEINER CK: La transmission de la paralysie infantile au chimpanzé, Compt. rend. Acad. d. sc., 1909, cxlix, 1014-1016. Google Scholar11. FLEXNERLEWIS SPA: Epidemic poliomyelitis in monkeys: a mode of spontaneous infection, Jr. Am. Med. Assoc., 1910, liv, 535. CrossrefGoogle Scholar12. FLEXNERRHOADS SCP: A method for the determination of the activity of antipoliomyelitis serum, Proc. Nat. Acad. Sci., 1929, xv, 609. CrossrefGoogle Scholar13. KLINGLEVADITILÉPINE CCP: La pénétration de virus poliomyélitique à travers la muqueuse du tube digestif chez le singe et sa conservation dans l'eau, Bull. Acad. de méd., Paris, 1929, cii, 158-165. Google Scholar14. CLARKROBERTSPRESTON PFDJWS: Passage of poliomyelitis virus through the intestinal tract, Jr. Prev. Med., 1932, vi, 47-58. Google Scholar15. AMOSS HL: Communicability and serum treatment of poliomyelitis, New York State Jr. Med., 1922, xxii, 256-259. Google Scholar16. BRODIE M Cited in: Poliomyelitis, a survey made possible by a grant from the International Committee for the Study of Infantile Paralysis, 1932, Williams and Wilkins Co., Baltimore, p. 83. Google Scholar17. TOOMEY JA: Spread of poliomyelitis virus from the gastrointestinal tract, Proc. Soc. Exper. Biol. and Med., 1934, xxxi, 680-681. CrossrefGoogle Scholar18. TOOMEY JA: Some reflex changes in poliomyelitis, Am. Jr. Dis. Child., 1933, xlvi, 730-742. Google Scholar19. TOOMEY JA: Reflex changes in typhoid fever, Am. Jr. Dis. Child. (In press.) Google Scholar20. TOOMEY JA: Reactions of patients with infantile paralysis to autonomic drugs, Am. Jr. Dis. Child., 1934, xlvii, 573-577. Google Scholar21. TOOMEY JA: A note on the spread of poliomyelitis virus in monkeys, Proc. Soc. Exper. Biol. and Med., 1934, xxxi, 702-705. CrossrefGoogle Scholar22. TOOMEY JA: The intestine and urinary bladder in poliomyelitis, Am. Jr. Dis. Child., 1933, xlv, 1211-1215. Google Scholar23. SHOPE RE; Swine influenza. III. Filtration experiments and etiology, Jr. Exper. Med., 1931, liv, 373-385. CrossrefGoogle Scholar24. Oroya fever. Current Comment, Jr. Am. Med. Assoc., 1933, c, 191. Google Scholar25. TOOMEY JA: Demonstration of a toxic factor in the stools and urines of poliomyelitis patients, Jr. Prev. Med., 1932, vi, 379-386. Google Scholar26. TOOMEYVON OETTINGEN JAWF: An entero depressant factor in stools of monkeys infected with experimental poliomyelitis, Proc. Soc. Exper. Biol. and Med., 1932-1933, xxx, 1082-1083. Google Scholar27. TOOMEY JA: Changes in titers of agglutinins for enteric organisms in the blood serum in poliomyelitis, Jr. Infect. Dis., 1934, liv, 74-80. CrossrefGoogle Scholar28. TOOMEY JA: Non-specific immunization of monkeys against poliomyelitis virus. (In preparation.) Google Scholar29. MÜLLER E: Über die Frühstadien der spinalen Kinderlähmung, München. med. Wchnschr., 1909, lvi, 2460-2462. Google Scholar30. TAYLOR HD: Blood counts in experimental poliomyelitis in monkeys, Jr. Exper. Med., 1919, xxix, 97. CrossrefGoogle Scholar31. GAYLUCAS FPWP: Anterior poliomyelitis: methods of diagnosis from spinal fluid and blood in monkeys and in human beings, Arch. Int. Med., 1910, vi, 330-338. CrossrefGoogle Scholar32. PEABODYDRAPERDOCHEZ FWGAR: A clinical study of acute poliomyelitis, Monograph of the Rockefeller Institute for Medical Research, Number 4, 1912, 1-187. Google Scholar33. HARMONSHAUGHNESSYGORDON PHHJFB: Preparalytic poliomyelitis in the monkey: changes in temperature, spinal fluid, blood and erythrocyte sedimentation, Jr. Prev. Med., 1931, v, 115-137. Google Scholar34. TOOMEYRANTA JAKE: Blood counts and temperature changes in monkeys experimentally infected with poliomyelitis. (In preparation.) Google Scholar35. OSLERMCCRAE WT: The principles and practice of medicine, 10th Ed., 1926, D. Appleton and Co., New York, page 25. Google Scholar36. TOOMEYAUGUST JAMH: Poliomyelitis: comparison between the epidemic peak and the harvest peak, Am. Jr. Dis. Child., 1933, xlvi, 262-279. CrossrefGoogle Scholar37. AYCOCKEATON WLP: The biseasonal prevalence of infantile paralysis (acute anterior poliomyelitis), Am. Jr. Hyg., 1924, iv, 356-364. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Cleveland, Ohio*Read at the Chicago meeting of the American College of Physicians, April 18, 1934.From the Department of Pediatrics, Western Reserve University, and the Division of Contagious Diseases, City Hospital, Cleveland, Ohio. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byThe Pathogenesis of Acute Poliomyelitis. Histologic Examination of the Peripheral Sympathetic Nervous System And the Olfactory Bulbs.Infection and immunity virus diseases: General considerationsThe gastrointestinal portal of entry in poliomyelitisObservations on the prophylactic value of specific immune serum in experimental poliomyelitisIntranasal or Gastrointestinal Portal of Entry in Poliomyelitis 1 January 1935Volume 8, Issue 7Page: 854-864KeywordsHypothalamusPediatricsPoliomyelitisThalamus ePublished: 1 December 2008 Issue Published: 1 January 1935 PDF downloadLoading ...