OSTEOPOROSIS IN CUSHING'S SYNDROME
Authors: A IANNACCONE, J L BABRILOVE, S A BRAHMS, L J SOFFER
Journal: Annals of Internal Medicine (1960)

Article1 March 1960OSTEOPOROSIS IN CUSHING'S SYNDROMEA. IANNACCONE, M.D., J. L. GABRILOVE, M.D., F.A.C.P., S. A. BRAHMS, M.D., L. J. SOFFER, M.D., F.A.C.P.A. IANNACCONE, M.D.Search for more papers by this author, J. L. GABRILOVE, M.D., F.A.C.P.Search for more papers by this author, S. A. BRAHMS, M.D.Search for more papers by this author, L. J. SOFFER, M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-52-3-570 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptOsteoporosis is a striking and serious feature of Cushing's syndrome. This manifestation of the disease is evidenced by the demineralization seen on the roentgenogram, and by the frequent occurrence of pathologic fractures. Indeed, the collapse of the weakened vertebrae causes shortness of stature and contributes to the characteristic truncal obesity of the patient with this disease. It has been known for many years that, following cure of the disease, further collapse of the vertebrae ceases and pathologic fractures no longer appear. However, there are scant data as to what occurs in the bony skeleton following successful treatment of the disease....Bibliography1. Skeels RF: Reversibility of osteoporosis in Cushing's disease: Case report, J. Clin. Endocrinol. and Metabolism 18: 61, 1958. CrossrefGoogle Scholar2. Moldawer M: Concerning the reversibility of osteoporosis, J. Clin. Endocrinol. and Metabolism 18: 1028, 1958. CrossrefGoogle Scholar3. AlbrightReifenstein FEC: The parathyroid glands and metabolic bone disease, 1948, The Williams and Wilkins Company, Baltimore. Google Scholar4. WangRobbins CCLL: Cushing's disease: its roentgenographic findings, Radiology 67: 17, 1956. CrossrefMedlineGoogle Scholar5. Howard JE: Osteoporosis in hyperadrenocorticism, J. Clin. Endocrinol. and Metabolism 18: 1131, 1958. CrossrefGoogle Scholar6. SkanseGydellWulffKoch BKHBF: Cushing's syndrome and its response to adrenalectomy, Acta med. Scandinav. 154: 119, 1956. CrossrefMedlineGoogle Scholar7. Sissons HA: Osteoporosis of Cushing's syndrome, J. Bone and Joint Surg. 38: 418, 1956. CrossrefMedlineGoogle Scholar8. Follis RH: Pathology of the osseous changes in Cushing's syndrome in an infant and in adults, Bull. Johns Hopkins Hosp. 88: 440, 1951. MedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: New York, N. Y.*Received for publication May 16, 1959.Presented at the Fortieth Annual Session of The American College of Physicians, Chicago, Illinois, April 23, 1959.From the Endocrine Research Laboratory and Clinic of the Department of Medicine and the Departments of Chemistry and Radiology, The Mount Sinai Hospital, New York, N. Y.†Research Fellow in Endocrinology. Aided by a Fellowship from the Dazian Foundation. Present Address: Metabolic Unit, Institute for Occupational Medicine, University of Florence, Italy.Requests for reprints should be addressed to J. Lester Gabrilove, M.D., The Mount Sinai Hospital, Fifth Avenue and 100th Street, New York 29, N. Y. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byDecreased Bone Mineral Density in Medicated Psychiatric PatientsReversion of the steroid-induced decrease of serum osteocalcin with sodium fluorideTotal body calcium measurements using neutron-activation analysis in Cushing's syndromeAdrenal CortexRisk factors for spinal osteoporosis in menHormonale Osteopathien im ErwachsenenalterHormonale Osteopathien im ErwachsenenalterHormonal Modifiers of Mineral Metabolism Other Than Parathyroid Hormone, Vitamin D, and CalcitoninAPPENDIX IThe Measurement of Serum Alkaline Phosphatase in Clinical MedicineVertebral compression fractures with accelerated bone turnover in a patient with Cushing's diseaseClinical Utilization of Alkaline Phosphatase MeasurementsDie NebennierenrindeOsteoporosis: Pathogenesis and TherapyDiagnosis and treatment of disorders of the adrenal cortexAdrenal CortexCorticosteroid osteoporosisCushing's syndrome and avascular necrosis of bone associated with carcinoid-islet cell tumor of the pancreasOn the Development of Osteoporosis: Experimental Studies in the Adult RatOn the Pharmacologic Actions of 21-Carbon Hormonal Steroids (“Glucocorticoids”) of the Adrenal Cortex in MammalsCHANGES IN BODY COMPOSITION DURING LONG-TERM TREATMENT WITH CORTISONE AND ANABOLIC STEROIDS IN ASTHMATIC SUBJECTSQuantitative microradiographic study of bone remodeling in Cushing's syndromeThe development of bilateral adenomatous adrenal hyperplasia in a case of Cushing's syndrome of eighteen years' durationNitrogen-Retaining Steroids and Their Application in DiseaseRheumatism and Arthritis Review of American and English Literature of Recent Years (Fifteenth Rheumatism Review)CHARLEY J. SMYTH, M.D., F.A.C.P., FELIX E. DEMARTINI, M.D., F.A.C.P., EPHRAIM P. ENGLEMAN, M.D., F.A.C.P., EDWARD C. FRANKLIN, M.D., DONALD F. HILL, M.D., F.A.C.P., JOSEPH LEE HOLLANDER, M.D., F.A.C.P., HOWARD L. HOLLEY, M.D., F.A.C.P., JOHN G. MAYNE, M.D., F.A.C.P., WILLIAM M. MIKKELSEN, M.D., F.A.C.P., MAX M. MONTGOMERY, M.D., F.A.C.P., CARL M. PEARSON, M.D., F.A.C.P., CHARLES L. SHORT, M.D., F.A.C.P., HUGH A. SMYTHE, M.D., F.R.C.P. (C), OTTO STEINBROCKER, M.D. 1 March 1960Volume 52, Issue 3Page: 570-586KeywordsDiagnostic radiologyEndocrinologyFellowshipsHospital medicineObesityOsteoporosisResearch laboratoriesSkeletonSpineVertebrae ePublished: 1 December 2008 Issue Published: 1 March 1960 PDF downloadLoading ...