tbuckley/cabot-search huggingface dataset:
Interspecific hybrid ancestry of a plant adaptive radiation: allopolyploidy of the Hawaiian silversword alliance (Asteraceae) inferred from floral homeotic gene duplications
Authors: M. Barrier, B. G. Baldwin, R. H. Robichaux, M. D. Purugganan
Journal: Molecular Biology and Evolution (1999)

The polyploid Hawaiian silversword alliance (Asteraceae), a spectacular example of adaptive radiation in plants, was shown previously to have descended from North American tarweeds of the Madia/Raillardiopsis group, a primarily diploid assemblage. The origin of the polyploid condition in the silversword alliance was not resolved in earlier biosystematic, cytogenetic, and molecular studies, apart from the determination that polyploidy in modern species of Madia/Raillardiopsis arose independent of that of the Hawaiian group. We determined that two floral homeotic genes, ASAP3/TM6 and ASAP1, are found in duplicate copies within members of the Hawaiian silversword alliance and appear to have arisen as a result of interspecific hybridization between two North American tarweed species. Our molecular phylogenetic analyses of the ASAP3/TM6 loci suggest that the interspecific hybridization event in the ancestry of the Hawaiian silversword alliance involved members of lineages that include Raillardiopsis muirii (and perhaps Madia nutans) and Raillardiopsis scabrida. The ASAP1 analysis also indicates that the two species of Raillardiopsis are among the closest North American relatives of the Hawaiian silversword alliance. Previous biosystematic evidence demonstrates the potential for allopolyploid formation between members of the two North American tarweed lineages; a vigorous hybrid between R. muirii and R. scabrida has been produced that formed viable, mostly tetraporate (diploid) pollen, in keeping with observed meiotic failure. Various genetic consequences of allopolyploidy may help to explain the phenomenal evolutionary diversification of the silversword alliance.
Risk of Fatal Pulmonary Embolism in Patients With Treated Venous Thromboembolism
Authors: James D. Douketis
Journal: JAMA (1998)

The most serious complication of deep vein thrombosis (DVT) or nonfatal pulmonary embolism (PE) is fatal PE. However, reliable estimates as to the risk of fatal PE in patients with treated DVT or PE are lacking.To provide reliable estimates of the risk of fatal PE and the case-fatality rate of recurrent DVT or PE among patients presenting with symptomatic DVT or PE, during and following 3 months of anticoagulant therapy.A MEDLINE literature search was performed to identify prospective studies in which patients with symptomatic DVT or PE were treated with 5 to 10 days of heparin and 3 months of oral anticoagulants. We searched the years 1966 to September 1997 using the search terms thrombophlebitis, diagnosis, drug therapy, and prognosis. Current Contents and bibliographies were also scanned.Of 137 retrieved studies, 25 studies satisfied predetermined methodologic criteria and were included in the analysis.Among patients presenting with DVT, the rate of fatal PE during anticoagulant therapy was 0.4% (95% confidence interval [CI], 0.2%-0.6%); following anticoagulant therapy it was 0.3 per 100 patient-years (95% CI, 0.1-0.8). The case-fatality rate of recurrent DVT or PE during anticoagulant therapy was 8.8% (95% CI, 5.0%-14.1%); following anticoagulant therapy it was 5.1% (95% CI, 1.4%-12.5%). Among patients presenting with PE, the rate of fatal PE during anticoagulant therapy was 1.5% (95% CI, 0.9%-2.2%); following anticoagulant therapy it was 0 per 265 patient-years (95% CI, 0-3.6). The case-fatality rate of recurrent DVT or PE among patients presenting with PE was 26.4% (95% CI, 16.7%-38.1%).Among patients with symptomatic PE or DVT who are treated with anticoagulants for 3 months, fatal PE is rare during and following anticoagulant therapy. Patients presenting with PE are more likely to die of recurrent PE or DVT than are patients presenting with DVT.
Identification and Characterization of T-Cell Epitopes Deduced from <i>RGS5</i>, a Novel Broadly Expressed Tumor Antigen
Authors: Cristina N. Boß, Frank Grünebach, Katharina Brauer, Maik Häntschel, Valbona Mirakaj, Toni Weinschenk, Stefan Stevanovic, Hans-Georg Rammensee, Peter Brossart
Journal: Clinical Cancer Research (2007)

Abstract Purpose: Identification of tumor-associated antigens and advances in tumor immunology resulted in the development of vaccination strategies to treat patients with malignant diseases. In a novel experimental approach that combined comparative mRNA expression analysis of defined cell types with the characterization of MHC ligands by mass spectrometry, we found that regulator of G protein signaling 5 (RGS5) is extensively up-regulated in a broad variety of malignant cells, and we identified two HLA-A2– and HLA-A3–binding peptides derived from the RGS5 protein. Interestingly, RGS5 was recently shown to be involved in tumor angiogenesis. Experimental Design: We used monocyte-derived dendritic cells pulsed with these novel antigenic peptides or transfected with RGS5-mRNA for the in vitro induction of CTLs, generated from healthy donors, to analyze the presentation of RGS5-deduced epitopes by malignant cells. Results: The generated CTL lines elicited an antigen-specific and HLA-restricted cytolytic activity against tumor cells endogenously expressing the RGS5 protein. Furthermore, we were able to induce RGS5-specific CTLs using peripheral blood mononuclear cells from a patient with acute myeloid leukemia capable of recognizing the autologous leukemic blasts while sparing nonmalignant cells. Conclusions: These results indicate that the RGS5 peptides represent interesting candidates for the development of cancer vaccines designed to target malignant cells and tumor vessels.
Alcoholism as Willful Misconduct-Reply
Authors: Thomas V. Seessel
Journal: JAMA (1989)

In Reply.—  Fortunately for recovering alcoholic veterans,  US Congress enacted legislation on Oct 20 providing that the disabling effects of chronic alcoholism shall not be considered to be  result of willful  for determining eligibility for a time extension to utilize GI Bill education benefits.  This moots  recent Supreme Court decision. By eliminating  willful misconduct label, Congress has removed one more inaccurate and stigmatizing characterization of America's leading drug problem.
Case number 20
Authors: G. D Wright
Journal: Annals of the Rheumatic Diseases (2000)

A 70 year old recent Russian female emigrant was admitted to our ward with a deep venous thrombosis of the left femoral vein.She reported a four year history of seronegative "rheumatoid arthritis" (RA).She also had symmetrical, shiny, smooth, firm, and spherical papules and nodules of waxy colour that coalesced to form band-like lesions on her face (fig 1).These lesions started one year before admission and progressed over time.Her tongue was diVusely enlarged.
Diabetes Mellitus Activates Signal Transduction Pathways Resulting in Vascular Endothelial Growth Factor Resistance of Human Monocytes
Authors: Vadim Tchaikovski, Servé Olieslagers, Frank -D. Böhmer, Johannes Waltenberger
Journal: Circulation (2009)

Background— Monocytes are cellular components of wound repair, arteriogenesis, and atherogenesis. Vascular endothelial growth factor (VEGF)-A and placental growth factor recruit monocytes to sites of arteriogenesis via stimulation of VEGF receptor-1 (VEGFR-1). The chemotactic response of monocytes to VEGF-A is attenuated in individuals with diabetes mellitus (DM). This VEGF resistance correlates with impaired collateral growth. The aim of this study is to elucidate the molecular basis of VEGF resistance and impaired monocyte response in DM. Methods and Results— Phosphorylation of Akt, p38, and extracellular signal-regulated kinase 1/2 (ERK1/2) could be stimulated with either placental growth factor-1 or VEGF-A in monocytes from non-DM but not DM individuals. In contrast, formyl-methionyl-leucyl-phenylalanine caused a comparable activation of these molecules in both DM and non-DM monocytes. Baseline phosphorylation of Akt, p38, and ERK1/2 was significantly elevated in monocytes from DM compared with non-DM subjects. Of note, H 2 O 2 activated Akt, p38, and ERK1/2 in non-DM monocytes ex vivo. Protein tyrosine phosphatases had stronger oxidative modifications in monocytes from DM than from non-DM individuals, which reflects functional protein tyrosine phosphatase inhibition, similar to that seen after H 2 O 2 challenge. Overall, protein tyrosine phosphatase and protein tyrosine phosphatase-1B activity were reduced in DM monocytes. DM monocytes revealed higher expression of the receptor for advanced glycation end products. Stimulation with advanced glycation end products ligands resulted in activation of non-DM monocytes and inhibition of VEGFR-1–mediated chemotaxis. The elevated baseline phosphorylation/activation of Akt, p38, and ERK1/2 in DM monocytes likely causes the resistance to further stimulation with specific stimuli such as VEGF-A, revealing a molecular explanation of the DM-related signal transduction defect. Conclusions— We propose that elevated advanced glycation end products expression and increased oxidative stress in diabetic monocytes lead to activation of VEGFR-1–related signaling pathways and to desensitization of VEGFR-1 responses. These data establish VEGF resistance as a novel molecular concept for DM-related cellular dysfunction.
Longitudinal dissociation in the His bundle. Bundle branch block due to asynchronous conduction within the His bundle in man.
Authors: O S Narula
Journal: Circulation (1977)

This report presents electrophysiological data in 27 patients (out of a series of 110) which suggest longitudinal disso- ciation in the His Bundle (BH).Twenty-five patients showed left bun- dle branch block (LBBB) which was rate related in three and two had isolated left axis deviation (LAD) with narrow QRS complexes.BH recordings were performed via the right heart, and in each patient the same electrode catheter was used for stimulation of the BH at different sites.The H-V time was prolonged (range 50-70 msec, mean 59) in all 22 patients with constant LBBB, in one of the three of the rate related LBBB, and in one of the two with isolated LAD; and remained unchanged throughout.In all 25 patients with LBBB prox- imal BH stimulation exhibited QRST complexes identical to those ON THE BASIS of their extensive histological studies, James and Sherf have recently reported that the longitudinal separation of Purkinje strands by collagen along with specialized nature of intercellular junctions within each strand form an anatomic basis for longitudinal separation of conduction within the normal His bundle.'These investiga- tors have proposed the concept of "sinoventricular conduc- tion" which implies that the individual components of the
Papageno v Werther effect
Authors: T. Niederkrotenthaler, M. Voracek, A. Herberth, B. Till, M. Strauss, E. Etzersdorfer, B. Eisenwort, G. Sonneck
Journal: BMJ (2010)

Sensationalist media reports, as in Hong Kong’s print media,1 can trigger further suicides—the Werther effect.2 However, we recently found that the effects of suicide related news stories was broad and sometimes protective, depending on the contents of the story.3 …
Identification of needs in biomarker research.
Authors: J B Ward, R E Henderson
Journal: Environmental Health Perspectives (1996)

Interest in the use of biological markers to evaluate future disease risk has increased greatly in recent years. Biomarkers are observable end points in a continuum of events leading from exposure to toxic agents to diseases that ultimately result from exposure. Because many significant diseases develop over long periods of time, methods for detecting early events that can predict risk are important for disease prevention. Biomarkers are generally categorized as detecting exposure, effects of exposure, or individual susceptibility to exposure. Although there has been significant progress in the technical development of biomarkers, implementation of their use in human populations has progressed much more slowly. We discuss four major needs in the development of biomarkers. First, new biomarkers need to be developed to fill gaps in our ability to observe steps in the continuum from exposure to disease. Second, the relationships between biomarker responses and disease pathology needs to be better understood. Third, the sensitivity, specificity, and variability of biomarkers need to be better characterized and they must be better validated as predictors of disease risk. Fourth, there are several societal impediments to the practical implementation of biomarker studies as public health tools. A common agreement among employers, employees, regulators, and the legal community must be established regarding appropriate and ethical uses and interpretation of biomarker data.
Determination of Microvessel Density by Quantitative Real-time PCR in Esophageal Cancer: Correlation with Histologic Methods, Angiogenic Growth Factor Expression, and Lymph Node Metastasis
Authors: Sonja Loges, Henning Clausen, Uta Reichelt, Michael Bubenheim, Andreas Erbersdobler, Paulus Schurr, Emre Yekebas, Gunter Schuch, Jakob Izbicki, Klaus Pantel, Carsten Bokemeyer, Walter Fiedler
Journal: Clinical Cancer Research (2007)

Angiogenesis and lymphangiogenesis are important steps in tumor growth and dissemination and are of prognostic importance in solid tumors. The determination of microvessel density (MVD) by immunohistology is subject to considerable variability between different laboratories and observers. We compared MVD determination by immunohistology and quantitative real-time PCR and correlated the results with clinical variables.The expression of endothelial antigens vascular endothelial cadherin (CD144), P1H12 (CD146), tie-2, and VEGFR-2, and lymphatic endothelial markers VEGFR-3, Prox, and LYVE was assessed by quantitative PCR (qPCR) in primary surgical samples. The expression of angiogenetic growth factors VEGF-A, VEGF-C, VEGF-D, angiopoietin-1, and angiopoietin-2 was quantified by PCR and correlated with MVD and clinical variables.The expression of endothelial antigens vascular endothelial cadherin (CD144), P1H12 (CD146), tie-2, and VEGFR-2 correlated with each other in 54 samples of primary esophageal cancer (P < 0.0001 for all comparisons). MVD determined immunohistologically by CD31 staining in a subgroup of 35 patients correlated significantly with the qPCR method. The expression of angiogenetic growth factors VEGF-A, VEGF-C, VEGF-D, angiopoietin-1, and angiopoietin-2 was significantly associated with MVD (P < 0.0001 for all comparisons). Analysis of the expression of lymphendothelial markers VEGFR-3, Prox, and LYVE revealed concordant results, indicating that quantification of lymphendothelial cells is possible by qPCR. The presence of lymph node metastasis on surgical specimens was significantly correlated with MVD (P < 0.003), VEGFR-2 (P < 0.048), and VEGF-C (P < 0.042) expression.These results indicate that quantification of MVD by qPCR in surgical samples of esophageal carcinoma yields similar results with immunohistology. Interestingly, the extent of angiogenesis and lymphangiogenesis was not related in individual tumor samples. Lymph node metastases could be predicted by MVD and VEGF-C expression.
Ischaemic colitis in the experimental animal. I. Comparison of the effects of acute and subacute vascular occlusion.
Authors: J G Matthews, T G Parks
Journal: Gut (1976)

Acute ligation of the common colic and caudal mesenteric artery in the dog led to ischaemic colitis, whereas the acute ligation of the common colic artery and gradual occlusion of the caudal mesenteric artery by an ameroid plastic device did not lead to ischaemic disease. These findings suggest that the collateral blood vessels do not open up rapidly enough to prevent ischaemic change when the two major arteries are acutely ligated.
380 REACTIVATION OF HEPATITIS B VIRUS IN HBSAG NEGATIVE PATIENTS UNDERGOING CHEMOTHERAPY FOR LYMPHOMA AND MULTIPLE MYELOMA: PROSPECTIVE SINGLE-INSTITUTION STUDY
Authors: T. Matsui, J.-H. Kang, K. Yane, T. Kin, H. Shida, K. Tsuji, H. Maguchi, Seisho Andoh, Sachiko Andoh, H. Sakai, M. Maemori, Y. Tanaka
Journal: Journal of Hepatology (2011)
Cellular Prion Protein Promotes<i>Brucella</i>Infection into Macrophages
Authors: Masahisa Watarai, Suk Kim, Janchivdorj Erdenebaatar, Sou-ichi Makino, Motohiro Horiuchi, Toshikazu Shirahata, Suehiro Sakaguchi, Shigeru Katamine
Journal: The Journal of Experimental Medicine (2003)

The products of the Brucella abortus virB gene locus, which are highly similar to conjugative DNA transfer system, enable the bacterium to replicate within macrophage vacuoles. The replicative phagosome is thought to be established by the interaction of a substrate of the VirB complex with macrophages, although the substrate and its host cellular target have not yet been identified. We report here that Hsp60, a member of the GroEL family of chaperonins, of B. abortus is capable of interacting directly or indirectly with cellular prion protein (PrPC) on host cells. Aggregation of PrPC tail-like formation was observed during bacterial swimming internalization into macrophages and PrPC was selectively incorporated into macropinosomes containing B. abortus. Hsp60 reacted strongly with serum from human brucellosis patients and was exposed on the bacterial surface via a VirB complex–associated process. Under in vitro and in vivo conditions, Hsp60 of B. abortus bound to PrPC. Hsp60 of B. abortus, expressed on the surface of Lactococcus lactis, promoted the aggregation of PrPC but not PrPC tail formation on macrophages. The PrPC deficiency prevented swimming internalization and intracellular replication of B. abortus, with the result that phagosomes bearing the bacteria were targeted into the endocytic network. These results indicate that signal transduction induced by the interaction between bacterial Hsp60 and PrPC on macrophages contributes to the establishment of B. abortus infection.
Imported Measles
Authors: John A. Frank
Journal: JAMA (1981)

From Dec 23, 1978, through Jan 31, 1979, an outbreak of five laboratory-confirmed cases and four clinical cases of measles occurred in a Vietnamese refugee population living in a single housing complex in Albuquerque, NM. The index cases were in two refugee siblings in whom measles was incubating on arrival in the United States. Despite spread through three subsequent generations of disease transmission within the Vietnamese population, there was no additional spread into the general Albuquerque population. Responsible factors included the age distribution of susceptible persons, the social isolation of the refugee population, and the physical structure of the housing complex. There is a need to identify the problem of imported measles in "ethnic islands" in need of vaccination.
Analysis of 2157 Cases of Labour
Authors: H. W. T. Ellis
Journal: BMJ (1859)

form vessel, lying about an inch above the clavicle, and cor- responding with the middle third of the subelavian artery.After a rest, and the subsidence of the bleeding, I made a care- ful examination, and found the heart in sound and rhythm, healthy; the chest clear on percussion, a systolic bruit not very loud being audible under the sternal articulation of the right clavicle.The innominata could be felt distinctly pul- sating at the top of the sternum.The carotid was dilated and removed from its position to the anterior triangle, assuming the shape of the italic letter S. The subelavian was also dilated, and on manipulation, the first sensation was that of a globular body; but on carefully examining the tumour, the
Züge der Situation Schizophrenie
Authors: Martti Siirala
Journal: Psychotherapy and Psychosomatics (1957)

Research Articles| February 10 2010 Züge der Situation Schizophrenie Subject Area: Psychiatry and Psychology Martti Siirala Martti Siirala Zürich Search for other works by this author on: This Site PubMed Google Scholar Acta Psychotherapeutica et Psychosomatica (1957) 5 (2-4): 196–204. https://doi.org/10.1159/000285290 Article history Published Online: February 10 2010 Content Tools Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Facebook Twitter LinkedIn Email Tools Icon Tools Get Permissions Cite Icon Cite Search Site Citation Martti Siirala; Züge der Situation Schizophrenie. Acta Psychotherapeutica et Psychosomatica 31 December 1957; 5 (2-4): 196–204. https://doi.org/10.1159/000285290 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAll JournalsActa Psychotherapeutica et Psychosomatica Search Advanced Search Article PDF first page preview Close Modal This content is only available via PDF. 1957Copyright / Drug Dosage / DisclaimerCopyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher.Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. You do not currently have access to this content.
Abstract 3807: Regulation of pancreatic, gliosarcoma and non-small cell lung cancer via CPI-613, a novel anticancer therapeutic agent
Authors: Candida N. Perera, Robert Rodriguez, Robert Shorr
Journal: Cancer Research (2012)

Abstract While the novel anticancer agent CPI-613, currently in clinical trials, is primarily known to affect multiple cancer cell energy metabolic processes and pathways, here we demonstrate that CPI-613 also shows cancer-cell-cycle-specific effects on BxPC3 (human pancreatic) cancer cells, SF539 (human gliosarcoma) cells, and H460 (human non-small cell lung cancer) cells but not on non-transformed NIH3T3 (murine fibroblast) cells. Specifically, gene microarray data demonstrates that CPI-613 affects signal transduction pathways and genes related to cell cycle maintenance and progression as well as energetic metabolic processes and pathways. The total RNA production was also significantly reduced in cancer cells treated with CPI-613 compared to non treated controls. Multiple cyclins, p27, p19, and CDK2 are specifically noted to be downregulated in cancer cells treated with this drug, thereby halting the cell cycle at multiple points. Further study of this phenomenon may lead to additional indications for CPI-613 treatment. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 103rd Annual Meeting of the American Association for Cancer Research; 2012 Mar 31-Apr 4; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2012;72(8 Suppl):Abstract nr 3807. doi:1538-7445.AM2012-3807