tbuckley/cabot-search huggingface dataset:
Abstract 13312: Risk Factors for the Development of Tachyarrhythmia Following the Norwood Procedure in the Single Ventricle Reconstruction Trial
Authors: Matthew Oster, Shan Chen, David Pober, Yaniv Bar-Cohen, Matthew Brothers, Nicole Cain, Steve Colan, Richard Czosek, Jamie Decker, David Gamboa, Salim Idriss, Joel Kirsh, Martin LaPage, Richard Ohye, Elizabeth Radojewski, Maully Shah, Eric Silver, Anoop Singh, Joel Temple, John Triedman, Jonathan Kaltman
Journal: Circulation (2014)

Background: Tachyarrhythmias are an important contributor to morbidity following the Norwood procedure for single ventricle congenital heart disease. The purpose of this study was to determine what demographic, preoperative, or operative factors may be associated with the development of postoperative tachyarrhythmias in this population. Methods: We performed a retrospective analysis of data collected prospectively through the multicenter Pediatric Heart Network Single Ventricle Reconstruction Trial for infants undergoing a Norwood procedure in 2005-2008. Our primary outcome of interest was any documented tachyarrhythmia requiring treatment or intervention during the inpatient postoperative stay. Subjects with a documented preoperative tachyarrhythmia (n=15) were excluded. After performing univariate chi-square analyses on a variety of candidate factors, we conducted multivariate stepwise logistic regression, including spline terms for nonlinearly associated variables, to calculate the adjusted odds ratios for the final variables. Results: Of 529 subjects, 108 (20%) had at least one documented tachyarrhythmia, with 11 having more than one. Tachyarrhythmias included: 77 supraventricular tachycardia, 23 junctional ectopic tachycardia, 10 atrial flutter, 7 ventricular tachycardia, and 2 atrial fibrillation. In the final multivariate model (c-statistic=0.65), significant factors associated with arrhythmia included receiving a modified Blalock-Taussig shunt, use of ultrafiltration, and age. (Table) Conclusions: Tachyarrhythmias are common following the Norwood procedure and are associated with the modifiable risk factors of shunt type and use of ultrafiltration. In addition, when surgery is performed between 8 and 20 days of age, older age is associated with a decreasing risk for tachyarrhythmia.
The fatty acid profile of the skin surface lipid layer in papulopustular rosacea
Authors: S. Ní Raghallaigh, K. Bender, N. Lacey, L. Brennan, F.C. Powell
Journal: British Journal of Dermatology (2011)

Background Patients with papulopustular rosacea (PPR) frequently complain of dry, sensitive skin. We have previously demonstrated that patients with PPR have reduced skin surface hydration levels in the presence of normal sebum casual levels, suggesting that it may be the quality and not the quantity of sebum that plays a role in PPR. Objectives To compare the sebaceous fatty acid composition of patients with PPR to that of controls with normal facial skin. Methods The sebaceous fatty acid composition of 25 patients with PPR and 24 age- and sex-matched controls was analysed by gas chromatography - mass spectrometry. Results Myristic acid (C14:0) was present in greater concentrations in PPR sebum, while the long chain saturated fatty acids arachidic acid (C20:0), behenic acid (C22:0), tricosanoic acid (C23:0) and lignoceric acid (C24:0) as well as the monounsaturated fatty acid cis-11-eicosanoic acid (C20:1) were present in the sebum of patients with PPR in lesser concentrations as compared with controls. Conclusions There is increasing evidence that sebaceous fatty acids play a role in the maintenance of skin barrier integrity. We have shown for the first time that patients with PPR have an abnormal sebaceous fatty acid composition, with reduced levels of long chain saturated fatty acids. These new findings may have therapeutic implications for the development of sebum-modifying nonantibiotic treatments for patients with PPR.
Original article: Two different profiles of peach allergy in the north of Spain
Authors: P. M. Gamboa, O. Cáceres, I. Antepara, R. Sánchez‐Monge, O. Ahrazem, G. Salcedo, D. Barber, M. Lombardero, M. L. Sanz
Journal: Allergy (2007)

Background: Peach allergy has two different patterns: central Europe with oral allergy syndrome (OAS) related to a primary sensitization to birch pollen Bet v 1 and profilins and southern Europe with mostly systemic symptoms, in many cases due to sensitization to lipid‐transfer proteins. Methods: Thirty peach‐allergic patients with positive skin and food challenge tests and 29 control subjects were included. Skin prick tests (SPT) with inhalant allergens, commercial peach and apple extracts and native Pru p 3 were performed. In vitro specific immunoglobulin (Ig) E to grass pollen, birch pollen, peach, apple, rBet v 1, rBet v 2 and rPhl p 12 was determined by CAP, and rBet v 1, rMal d 1, rMal d 4, rMal d 3 and rPru p 3 using the ADVIA‐Centaur platform. Basophil activation test (BAT) with commercial peach extract, commercial apple extract, nPru p 3, rMal d 3, rMal d 1 and rMal d 4 was also performed. Results: Pru p 3 was the major allergen in the patient group from northern Spain. Sensitization to this allergen was found in 100% of the patients with systemic symptoms or contact urticaria. Only 60% of OAS patients were sensitized to Pru p 3, being all of them sensitized to profilins and 60% of them to allergens of the Bet v 1 family. Specific IgE determination and BAT using recombinant allergens (rPru p 3) show specificity and sensitivity values close to 100%. Conclusions: Most peach‐allergic patients coming from the north of Spain present systemic symptoms after ingestion of peach, Pru p 3 being the main allergen. Patients with OAS present profilin‐Bet v 1‐related sensitization. Thus, in the north of Spain our patients show a mixed central‐south Europe pattern with LTP‐profilin‐Bet v 1 sensitization depending on the symptoms presented. The use of natural and recombinant plant allergens, allows establishing the sensitization patterns to the different allergens studied.
1032. Massive Expression of a Suicide Gene Using a Replicative but Non-Disseminative Adenovirus for Treatment of Solid Tumors
Authors: Denis Bourbeau, Cara Lau, Genevieve Lavoie, Anne-Marie Mes-Masson, Josephine Nalbantoglu, Bernard Massie
Journal: Molecular Therapy (2004)

Cancer gene therapy using suicide genes had shown great potential in animal models although the efficacy of this approach is still insufficient for complete tumor regression. To improve efficacies, recent attention has focused on the use of oncolytic vectors. To date this strategy has not resulted in vectors with anti-tumor activities sufficiently potent to sustain consistent complete tumor regression, although in a few instances complete regression has been observed. In this study, we pursued a modified approach that makes use of viral DNA replication but not of oncolysis. This approach is based on the protease-deleted adenovirus vector (AdV) (Oualikene et al. 2000). Such vectors are designed to convert transduced cells into mega-factories for suicide genes. To validate this strategy, we have introduced the suicide gene cytosine deaminase::uracil phosphoribosyl transferase (CD::UPRT) into the replicative but non-disseminative AdV. In AdV the CD::UPRT transgene and the E1A gene were introduced as a bicitronic cassette under the control of the CMV5 promoter. This adenovirus was generated by introducing the expression cassette in the E1 region of an AdV backbone deleted for E1, E3, and the protease gene. Due to the protease deletion, this AdV can no longer form viral particles, even following replication resulting from E1A expression. The resulting Ad(dPS)C::U-IRES-E1A was grown in protease-complementing 293 cells. When tested for anti-tumor activities in two glioblastomas cell lines and two ovarian cancer cell lines, this Ad(dPS)C::U-IRES-E1A outperformed its non-replicative counterpart, the AdC::U-IRES-GFP, by up to 45-fold. In bystander assays, the number of transduced cells sufficient to convey the anti-tumor activity to the entire cell population could be reduced by more than 25-fold when comparing Ad(dPS)C::U-IRES-E1A to AdC::U-IRES-GFP. In a three dimensional spheroid cutlure model, anti-tumor activity was obtained with 25 times less particles when the replicative non-disseminative AdV was compared to AdC::U-IRES-GFP. In conclusion, the replicative but non-disseminative AdV platform substantially improves anti-tumor activity of suicide gene therapy with CD::UPRT and probably occurs through the activation of viral gene expression and DNA replication although the intrinsic anti-tumor activity of the E1A protein could also be a factor in the improved potency of AdC::U-IRES-E1A. This work demonstrated that the protease-deleted AdV platform may provide vectors that are potentially safer than conditional oncolytic AdVs and yet generate sufficient anti-tumor activity to eradicate large tumors. Work with animal models is in progress and preliminary results will be discussed.
Imatinib mesylate therapy for relapse after allogeneic stem cell transplantation for chronic myelogenous leukemia
Authors: Hagop M. Kantarjian, Susan O'Brien, Jorge E. Cortes, Sergio A. Giralt, Mary Beth Rios, Jianqin Shan, Francis J. Giles, Deborah A. Thomas, Stefan Faderl, Marcos De Lima, Guillermo Garcia-Manero, Richard Champlin, Ralph Arlinghaus, Moshe Talpaz
Journal: Blood (2002)
When I use a word: Round the back
Authors: J. Aronson
Journal: BMJ (2002)

The Latin word lumbus, from which we get lumbar, meant the loin, and was usually used in the plural, lumbi. In the 19th century the middle of the back in the region of the loins became known as the lumbar region—hence a lumbar puncture, first performed on dead bodies by Cotugno in the middle of the 18th century but not introduced into clinical practice until 1891, by Quincke.

In Latin the suffix -ago, or -igo, or -ugo was often used to denote a disease, giving us albugo (a white opacification of the cornea), caligo (dim vision), impetigo, intertrigo, lentigo, porrigo (dandruff), prurigo, serpigo, tentigo (priapism), vertigo, and vitiligo, more than half of them diseases …
Effects of restoring portal flow with anticoagulation and partial splenorenal shunt embolization
Authors: Nicolas M. Intagliata, Wael E. Saad, Stephen H. Caldwell
Journal: Hepatology (2014)

1University of Virginia Health System, Division of Gastroenterology and HepatologyUniversity of VirginiaCharlottesvilleVA 2University of Michigan Health System, Division of Interventional RadiologyUniversity of MichiganAnn ArborMI *Address reprint requests to: Nicolas Intagliata, M.D., PO Box 800708, Charlottesville, VA 22908. E‐mail: [email protected]; fax: 434‐244‐7529.
Abstract 102: School Teachers Can Effectively Instruct Children in Cardiopulmonary Resuscitation Using Personal Manikin and Instructional Video: Randomized Trial
Authors: Migaku Kikuchi, Masaaki Satoh, Norimasa Seo, Teruo Inoue, Tetsuya Sakamoto, Seishiro Marukawa, Hiroshi Nonogi, Sch Cpr Investigators
Journal: Circulation (2010)

Background: Widespread training is required to increase the incidence of cardiopulmonary resuscitation (CPR) by lay persons. Mass training of CPR for school children is the key issue for the spread...
PUBLIC HEALTH CONTROL OF SYPHILIS
Authors: Thomas Parran
Journal: Annals of Internal Medicine (1936)

Article1 July 1936PUBLIC HEALTH CONTROL OF SYPHILISTHOMAS PARRAN JR., M.D.THOMAS PARRAN JR., M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-10-1-65 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptAs one after another of the epidemic diseases has declined or disappeared under the impact of public health effort, it is natural that the same technics should be directed against other major causes of sickness and death. Moreover the success of past and current public health measures has engendered the confidence of the tax-paying public which will support extension of community action into fields heretofore reserved to private effort.These two facts make it inevitable that the public health control of syphilis should be the central problem now faced by health departments. In undertaking any public health measure, those of... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Albany, N. Y.*Read at the Detroit meeting of the American College of Physicians, March 3, 1936. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byDanger, Disease, and Despotism: Balancing on the Tightrope of Chicago 1 July 1936Volume 10, Issue 1Page: 65-72KeywordsPrevention, policy, and public healthSyphilis ePublished: 1 December 2008 Issue Published: 1 July 1936 PDF downloadLoading ...
Allergic contact dermatitis to plant extracts in patients with cosmetic dermatitis
Authors: K.F. Thomson, S.M. Wilkinson
Journal: British Journal of Dermatology (2000)

Cosmetic contact allergy is commonly seen in patients undergoing patch testing, with fragrance one of the most frequently implicated ingredients. Many cosmetics contain plant extracts either as a fragrance or for medicinal properties. With a vogue for natural products there is an increase in their use. We have performed a prospective study over a 2-year period looking at the prevalence of contact allergy to plants in patients diagnosed with cosmetic dermatitis. In addition, we have performed a review of the products of two popular cosmetic companies, examining product labelling and the prevalence of use of plant extracts. We suggest that patients allergic to fragrance be advised to avoid plant extracts, which are separately labelled, in their personal care products.
Abstract 71: The Effect of Achieving Return of Spontaneous Circulation on Mitochondrial Respiration Following Prolonged Cardiac Arrest
Authors: Timothy R Matsuura, Jason A Bartos, Guillaume Debaty, Scott H McKnite, Jennifer N Rees, Matthias L Riess, Demetris Yannopoulos
Journal: Circulation (2014)

Introduction: Ischemia and reperfusion injury have been shown to alter mitochondrial function. Respiration, a primary function of mitochondria and marker of mitochondrial health, was previously believed to be unrecoverable after prolonged cardiac arrest. We investigated the effect that return of spontaneous circulation (ROSC) has on the mitochondrial respiratory profile of the myocardium. Methods: After 15 minutes of untreated ventricular fibrillation (VF), 16 pigs received mechanical CPR and intravenous epinephrine per standard AHA protocols. Defibrillation was first attempted after 4 minutes of CPR. In the event of persistent VF or pulseless electrical activity, CPR was continued for up to 15 minutes with epinephrine and defibrillations administered every 3 minutes. Animals that had ROSC were sacrificed 15 minutes after the initiation of resuscitation efforts. Another 6 animals were used as non-ischemic controls and had no cardiac arrest. Cardiac mitochondria were isolated. Respiration for complex I and complex II substrates was measured. Respiratory control index (RCI) was calculated as the ratio of state 3 to state 4 respiration. Mean RCI were compared via t-test and ANOVA. A p-value of &lt; 0.05 was considered significant. Results: ROSC was achieved in 10 of 16 animals. Fifteen minutes after initiation of resuscitation efforts, animals that achieved ROSC had significantly higher complex I RCI compared to animals with ongoing CPR (8.0±0.8 vs. 4.3±0.4, p&lt;0.01). Complex I RCI in animals that achieved ROSC recovered to that of non-ischemic controls (8.0±0.8 vs. 6.3±0.5, p=0.17). Complex II RCI did not differ between ROSC, CPR, and non-ischemic controls (3.2±0.3 vs. 2.7 ±0.2 vs. 3.2±0.1, respectively; p=0.40). Conclusion: Achieving ROSC after prolonged untreated cardiac arrest leads to normalization of mitochondrial respiration within 15 minutes of the initiation of resuscitation efforts. At the same time, complex I RCI is suppressed and complex II RCI is unaffected during ongoing CPR. Decreased mitochondrial complex I respiration during ongoing CPR could be the cause or the effect of the absence of ROSC. Further investigation is needed.
Abstract 12969: Rapid Nonsustained Ventricular Tachycardia Detected by Continuous Device Monitoring for Risk Stratification in Hypertrophic Cardiomyopathy: Redefining a Traditional Risk Marker
Authors: Karthik Viswanathan, Adrian M Suszko, Nicholas M Jackson, Douglas Cameron, Danna A Spears, Harry Rakowski, Anna Woo, Mamta Khurana, Vijay S Chauhan
Journal: Circulation (2014)

Introduction: Nonsustained VT (NSVT) detected by Holter (Holter +NSVT) is a major risk factor (RF) for sudden cardiac death (SCD) in hypertrophic cardiomyopathy (HCM). We hypothesized that using a higher heart rate cut-off and prolonged monitoring for detecting NSVT would improve its accuracy in predicting sustained ventricular arrhythmias (VA). Methods: We prospectively enrolled 56 patients (mean 44±14 yrs) with HCM, who had a preexisting prophylactic ICD. We assessed the prevalence of rapid NSVT (+RNSVT, ≥4 beats at 167-200 bpm) detected by their ICD within the first 12 months of implant. The primary outcome was appropriate ICD therapy after implant. Results: The prevalence of RF at ICD implant was 50% for syncope, 57% for Holter +NSVT, 45% for +family history SCD, and 25% for septum ≥ 30mm. The prevalence of 0, 1, 2 and ≥3 RF was 2, 32, 54 and 13%, respectively. +RNSVT occurred in 19 patients (34%) of whom 4 were Holter -NSVT. When compared to -RNSVT, those with +RNSVT had less syncope (21 vs 65%, p=0.004) but more Holter +NSVT (79 vs 46%, p=0.02). Over a median follow-up of 59 (25, 123) months after ICD implant, 8 patients had ≥1 appropriate ICD therapy from VA. According to the number of RF, the proportion of patients with VA was 0=0%, 1=6%, 2=13%, ≥3=43% (p=0.11). +RNSVT was associated with higher VA compared to Holter +NSVT (Figure 1A). +RNSVT predicted VA by Cox regression analysis, both univariate [odds ratio 10, 95% CI 1-84, p=0.03] and adjusted for differences in RF [adjusted odds ratio 11, 95% CI 1-114, p=0.046]. ROC analysis for +RNSVT (area under curve 0.78, p=0.02) showed the optimal cut-point to be RNSVT ≥2 episodes (Figure 1B) for discriminating patients with and without VA (Sensitivity 71%, Specificity 83%, PPV 38%, NPV 95%). Conclusions: RNSVT detected from continuous device monitoring is an independent predictor of VA in HCM patients and a better risk stratifier than Holter +NSVT. The role of implantable loop monitoring to detect RNSVT and evaluate VA risk in HCM warrants study
Abstract 16311: Survival of Fontan Patients After Heart Transplant; Has Survival Improved in the Current Era?
Authors: Kathleen E Simpson, James K Kirklin, David C Naftel, Elizabeth Pruitt, Rakesh Singh, R E Edens, Aliessa P Barnes, Charles E Canter
Journal: Circulation (2014)

Heart transplant (HT) after the Fontan procedure has been associated with increased mortality compared to other pediatric heart diseases. Recent data from the Pediatric Heart Transplant Study demonstrated improved survival after HT over time in children with congenital heart disease (CHD). We hypothesized that this trend extends to Fontan patients undergoing HT in the current era. Between 1993 to December 2012, 680 pediatric patients who were ≥ 2 years old at listing with CHD underwent HT, of which 254 had a prior Fontan Procedure. Era 1 (1993-2006: 175 Fontan, 376 non-Fontan CHD (NF-CHD)) was compared to Era 2 (2007-2012: 197 Fontan, 221 NF-CHD) for listed patients ≥ 2 years old. An analysis of survival and risk factors by multivariable analysis examined our study hypothesis. Similar to other groups, Fontan patients in the late era were more likely to be listed as status 1 (69 vs. 90%, p<0.0001), require inotropic support (55 vs. 69%, p=0.0218), have failure to thrive (20 vs. 36%, p=0.0038) and were youn...
680. Lipid-Mediated HSP27 Delivery Improves Functional Recovery Following Moderate Spinal Cord Contusion Injury
Authors: Justine J. Overman, Leon L. Hall
Journal: Molecular Therapy (2004)

There are approximately 11,000 new spinal cord injury cases per year, the majority of these cases occurring in males (80%) between the ages of 16 and 30. Tetraplegia and paraplegia each accounts for approximately 50% of patient outcomes. The functional outcome of SCI is determined by the cumulative cell death resulting from both the acute phase of injury, involving mechanical insult, and the secondary phase of injury, involving neurogenic shock, vascular insult, excitotoxicity, and the immune response. This cell death includes apoptotic mechanisms, which occur hours, days, and even weeks after the initial injury. The resulting CNS deficits are so severe as to warrant investigation of novel methods of preventing or minimizing these deficits. Non-viral gene therapy methods have gained widespread acceptance as a viable alternative to viral gene delivery. We have an ongoing program of lipid-mediated gene delivery for application to central nervous system injury and disease. We have optimized protocols for efficacious gene delivery to the brain, and have applied these same methods to the delivery of genes to the spinal cord. We have applied these methods to the delivery of genes targeting apoptotic mechanisms of secondary injury.
Abstract 8961: Essential Role of Caveolin-3 in Adiponectin Signalsome Formation and Adiponectin Cardioprotection
Authors: Yajing Wang, Erhe Gao, Xiaoliang Wang, Jean-Francois Jasmin, Wayne Bond Lau, Rong Li, Yuexing Yuan, Wei Yi, Kurt Chuprun, Michael P Lisanti, Walter J Koch, Xin-Liang Ma
Journal: Circulation (2011)

Adiponectin (APN) is an adipocyte-derived cardioprotective molecule, and systemic APN malfunction is causatively related to increased cardiovascular morbidity/mortality in diabetic patients. Although several APN receptors and multiple cytosolic effector molecules have been identified, signaling mechanisms linking receptors with effectors remain largely undefined. Caveolin (Cav) interacts with multiple membrane/intracellular proteins and regulates transmembrane signaling. However, the role of Cav in APN signaling remains unknown. Our current study determined the role of Cav3 (the predominant Cav form in cardiomyocytes) in APN signaling and investigated the underlying molecular mechanisms. Compared to wild type (WT), Cav-3 knockout (Cav-3KO) mice exhibited modestly increased myocardial ischemia/reperfusion injury (increased infarct size, apoptosis, and poorer cardiac function recovery, P&lt;0.05). Most importantly, the cardioprotective effects of APN observed in WT were either markedly reduced (P&lt;0.01) or completely lost in Cav-3KO, although key APN signaling molecules, including APN receptors (AdipoRs), APPL1, and AMPK were normal in these animals. Molecular/cellular experiments revealed that AdipoR1 co-localizes with Cav-3, forming AdipoR1/Cav-3 complex via specific Cav-3 scaffolding domain binding motifs. AdipoR1/Cav-3 interaction is required for both APN-initiated AMPK-dependent and AMPK-independent intracellular cardioprotective signaling. Moreover, APPL1 and adenylate cyclase (AC), two immediately downstream molecules respectively requisite for AMPK-dependent and AMPK-independent signaling, form a protein complex with AdipoR1 in Cav-3 dependent fashion. Finally, in contrast to APN (which failed to cardioprotect in Cav-3KO mice), AICAR (an AMPK activator) and db-cAMP (a PKA activator) co-administration significantly reduced myocardial infarct size and improved cardiac function in Cav-3KO animals. These results demonstrated for the first time that Cav-3 is an essential molecule in the formation of a membrane-situated signalsome for APN transmembrane signaling. Pathological alteration in APN signalsome formation may impair APN transmembrane signaling and contribute to systemic APN malfunction.