tbuckley/cabot-search huggingface dataset:
Escalated M-VAC chemotherapy and recombinant human granulocyte-macrophage colony stimulating factor (rhGM-CSF) in patients with advanced urothelial tract tumors
Authors: C.N. Sternberg, P.H.M. de Mulder, A.T. van Oosterom, S.D. Fossa, D. Giannarelli, J.R. Soedirman
Journal: Annals of Oncology (1993)
ANAEMIA IN DERMATITIS HERPETIFORMIS.
Authors: J. J. CREAM, G. L. SCOTT
Journal: British Journal of Dermatology (1970)

Summary— Forty-three patients being treated with dapsone for dermatitis herpetiformis were studied to determine the prevalence and mechanisms of anaemia in this condition. Anaemia was more common than in a comparable normal control group although it was usually mild. Most patients had evidence of drug-induced haemolysis which was dose related and this was the most important cause for anaemia. Malabsorption did not seem to be a significant factor in the development of anaemia. The incidence of iron deficiency was no greater than in the controls, despite urinary iron loss. Five patients had low levels of serum B12, of whom 3 had pernicious anaemia. The incidence of low serum folate levels was less than that found by other workers although serial estimations revealed considerable fluctuations. The possibility that patients with dermatitis herpetiformis are more susceptible to the haemolytic effects of dapsone and the possible effects of dapsone on oxygen transport are discussed.
Ependymomas, Malignant Tumors of Pancreatic Islets, and Osteosarcomas Induced in Hamsters by BK Virus, a Human Papovavirus&lt;xref ref-type="fn" rid="FN2"&gt;2&lt;/xref&gt;
Authors: A. Corallini, G. Altavilla, M. G. Cecchetti, G. Fabris, M. P. Grossi, P. G. Balboni, G. Lanza, G. Barbanti-Brodano
Journal: JNCI Journal of the National Cancer Institute (1978)

Journal Article Ependymomas, Malignant Tumors of Pancreatic Islets, and Osteosarcomas Induced in Hamsters by BK Virus, a Human Papovavirus Get access A. Corallini, A. Corallini 3Institute of Microbiology, University of Ferrara, Via Luigi Borsari 46, 1-44100 Ferrara, Italy. Search for other works by this author on: Oxford Academic PubMed Google Scholar G. Altavilla, G. Altavilla 4Institute of Pathologic Anatomy, University of Ferrara, Via Fossato di Mortara 64/b, 1-44100 Ferrara, Italy. Search for other works by this author on: Oxford Academic PubMed Google Scholar M. G. Cecchetti, M. G. Cecchetti 3Institute of Microbiology, University of Ferrara, Via Luigi Borsari 46, 1-44100 Ferrara, Italy. Search for other works by this author on: Oxford Academic PubMed Google Scholar G. Fabris, G. Fabris 4Institute of Pathologic Anatomy, University of Ferrara, Via Fossato di Mortara 64/b, 1-44100 Ferrara, Italy. Search for other works by this author on: Oxford Academic PubMed Google Scholar M. P. Grossi, M. P. Grossi 3Institute of Microbiology, University of Ferrara, Via Luigi Borsari 46, 1-44100 Ferrara, Italy. Search for other works by this author on: Oxford Academic PubMed Google Scholar P. G. Balboni, P. G. Balboni 3Institute of Microbiology, University of Ferrara, Via Luigi Borsari 46, 1-44100 Ferrara, Italy. Search for other works by this author on: Oxford Academic PubMed Google Scholar G. Lanza, G. Lanza 4Institute of Pathologic Anatomy, University of Ferrara, Via Fossato di Mortara 64/b, 1-44100 Ferrara, Italy. Search for other works by this author on: Oxford Academic PubMed Google Scholar G. Barbanti-Brodano G. Barbanti-Brodano 3Institute of Microbiology, University of Ferrara, Via Luigi Borsari 46, 1-44100 Ferrara, Italy. Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 61, Issue 3, September 1978, Pages 875–883, https://doi.org/10.1093/jnci/61.3.875 Published: 01 September 1978 Article history Received: 28 December 1977 Accepted: 22 March 1978 Published: 01 September 1978
Abstract 13207: Role of Membrane Type-1 Matrix Metalloproteinase Expression in Pressure-Overload Induced Left Ventricular Remodeling
Authors: Michael R Zile, Catalin F Baicu, An Van Laer, Risha K Patel, Laurel E Black, Robert E Stroud, Rupak Mukherjee, Francis G Spinale
Journal: Circulation (2010)
Endotracheal closure of a tracheoesophageal fistula using an atrial septal defect occluder device
Authors: Jing Li, Guohong Zeng, Shushui Wang, Xinglin Gao, Zhengxian Chen, Yuanliang Sun, Junwei Huang, Jingjing Chen, Zixing Chen
Journal: European Respiratory Journal (2013)

We report a large tracheoesophageal fistula successfully closed by means of implantation of an Atrial Septal Defect (ASD) Occluder device through trachea.  A 65-year-old male got a large tracheoesophageal fistula because of reintubation.  The patient was unable to tolerate surgery because of his poor condition. Approved by the Ethics Committee and obtained the informed consent, we chose ASD occluder device to close the fistula through trachea by bronchoscope.  The process was performed under general anesthesia. The occluder was conveyed through the fistula by guide wire and sheath. Both discs were expanded under direct vision of bronchoscope.  After the procedure, the patient’s condition recovered well. Three months later, we could see that the occluder expanded and fixed well.  The treatments for acquired tracheoesophageal fistulas, all with thier own disadvatages, include conservative treatments, surgery and endoscopy treatments.  The ASD occluder is self-expandable double-disc connected by a waist and filled with film. The encouraging efficacy in this case indicated that this procedure may be effective in selective patients.
Sentinel node biopsy as a practical alternative to axillary lymph node dissection in breast cancer patients: An approach to its validity
Authors: M. Fraile, M. Rull, F.J. Julián, F. Fusté, A. Barnadas, M. Llatjós, E. Castellà, J.R. Gonzalez, V. Vallejos, A. Alastrué, M.A. Broggi
Journal: Annals of Oncology (2000)
Trial in Progress: Phase 3 Randomized Study of Investigational Drug Alisertib (Mln8237) Vs Investigator'S Choice in Patients (Pts) with Relapsed/Refractory (Rel/Ref) Peripheral T-Cell Lymphoma (Ptcl): the Lumiere Trial
Authors: M. Özcan, A.R. Shustov, H. Liu, X. Zhou, C. Dansky Ullmann, V. Kelly, E.J. Leonard, O. O'connor
Journal: Annals of Oncology (2014)
Clinical Application of Prognostic Gene Expression Signature in Fusion Gene–Negative Rhabdomyosarcoma: A Report from the Children's Oncology Group
Authors: Pooja Hingorani, Edoardo Missiaglia, Janet Shipley, James R. Anderson, Timothy J. Triche, Mauro Delorenzi, Julie Gastier-Foster, Michele Wing, Douglas S. Hawkins, Stephen X. Skapek
Journal: Clinical Cancer Research (2015)

Abstract Purpose: Pediatric rhabdomyosarcoma (RMS) has two common histologic subtypes: embryonal (ERMS) and alveolar (ARMS). PAX–FOXO1 fusion gene status is a more reliable prognostic marker than alveolar histology, whereas fusion gene–negative (FN) ARMS patients are clinically similar to ERMS patients. A five-gene expression signature (MG5) previously identified two diverse risk groups within the fusion gene–negative RMS (FN-RMS) patients, but this has not been independently validated. The goal of this study was to test whether expression of the MG5 metagene, measured using a technical platform that can be applied to routine pathology material, would correlate with outcome in a new cohort of patients with FN-RMS. Experimental Design: Cases were taken from the Children's Oncology Group (COG) D9803 study of children with intermediate-risk RMS, and gene expression profiling for the MG5 genes was performed using the nCounter assay. The MG5 score was correlated with clinical and pathologic characteristics as well as overall and event-free survival. Results: MG5 standardized score showed no significant association with any of the available clinicopathologic variables. The MG5 signature score showed a significant correlation with overall (N = 57; HR, 7.3; 95% CI, 1.9–27.0; P = 0.003) and failure-free survival (N = 57; HR, 6.1; 95% CI, 1.9–19.7; P = 0.002). Conclusions: This represents the first, validated molecular prognostic signature for children with FN-RMS who otherwise have intermediate-risk disease. The capacity to measure the expression of a small number of genes in routine pathology material and apply a simple mathematical formula to calculate the MG5 metagene score provides a clear path toward better risk stratification in future prospective clinical trials. Clin Cancer Res; 21(20); 4733–9. ©2015 AACR.
The expression of stratum corneum chymotryptic enzyme in human anagen hair follicles: further evidence for its involvement in desquamation-like processes
Authors: None Ekholm, None Egelrud
Journal: British Journal of Dermatology (1998)

At sites with a continuous formation of cornified epithelia, there is need for continuous cell shedding in order to maintain normal anatomy. Stratum corneum chymotryptic enzyme (SCCE) has been suggested to mediate this process by degrading intercellular cohesive structures in interfollicular epidermis. In the hair follicle, there are several different kinds of cornification processes. With the exception of the formation of the hair shaft, these processes lead to a continuous formation of structures that have to be shed continuously in order to avoid distorting the anatomy of the follicle. In this work, we have investigated the possible involvement of SCCE in the turnover of cornified cells in anagen hair follicles. Using immunohistochemistry, we demonstrated the expression of SCCE in all parts of the follicle where cells are keratinized and eventually shed, i.e. in the uppermost follicle (distal to the opening of the sebaceous duct), in the sebaceous duct and in all parts of the inner root sheath (IRS). SCCE expression was also seen in those cells of the outer root sheath that are believed to move along with the IRS from the bulb and eventually become keratinized and sloughed in the part of the follicle situated between the terminal edge of the IRS and the opening of the sebaceous duct. We could not detect any SCCE in cells forming the hair shaft. Thus, there was a strong correlation between SCCE expression and the continuous formation and shedding of cornified epithelia in anagen hair follicles. This correlation was stronger for SCCE than for a number of common markers of terminal differentiation in keratinocytes. Our results give further support to a part for SCCE in desquamation-like processes. Whether SCCE is involved in diseases affecting hair growth remains to be elucidated.
Personality and emotional disorder in a community sample of migraine headache sufferers
Authors: J Brandt, D Celentano, W Stewart, M Linet, M F Folstein
Journal: American Journal of Psychiatry (1990)

To investigate whether individuals who suffer from chronic, severe headaches have more personality abnormalities or emotional disorders than their healthy counterparts, 162 young adults with classical migraine, ascertained by community survey, were compared to matched control subjects without migraine. On the General Health Questionnaire, the prevalence of psychological symptoms among the migraine subjects was 2.5 times the prevalence among the control subjects. The migraine sufferers also had significantly higher scores on the psychoticism (women only), neuroticism, and lie scales of the Eysenck Personality Questionnaire. Frequency of migraine attacks was not related to scores on any of the scales. These results suggest that classical migraine is associated with psychological abnormalities.
Pulmonary nocardiosis-always an opportunist infection?
Authors: Bianca Paraschiv, Claudia Toma, Ionela Belaconi, Stefan Dumitrache-Rujinski, Adriana Moisoiu, Alina Croitoru, Miron Bogdan
Journal: European Respiratory Journal (2013)

Introduction: Pulmonary nocardiosis is a rare and usually opportunist infection. Due to its clinical and radiological polymorphism the diagnosis is often delayed.

Material and method: We report 8 cases (5 males) of pulmonary nocardiosis diagnosed between 2007-2011. The mean age of the group was 65 yo. The predisposing factors were: vasculitis (3), pleurisy (1), bronchiectasis (3), interstitial lung disease (1). All patients were evaluated with sputum exam, chest X-ray, CT-scan, bronchoscopy.

Results: Symptoms at admission were: dyspnea and fatigue (8), cough (5), fever (1), hemoptisis (1). All patients had negative exams for My tuberculosis and HIV. In all cases the CT-scan revealed newly developed infiltrates and nodules.

![Figure][1] 



In 3 cases Nocardia was identified on smears and grew on culture from sputum, in 3 from cultures from pleural liquid, in 2 at necropsy. Five patients received treatment with trimethoprim-sulfamethoxazole with favorable outcome. Only one developed severe digestive adverse effects and he was changed on Linezolid and Imipenem.

Conclusions: Up to one third of Nocardiosis infections appear in imunocompetent hosts. To evoid the delayed of the diagnosis routinely specific stains and cultures for Nocardia spp are needed in patients with newly developed infiltrates or nodules on chest X-ray with no apparent reason.

Fig I: CT-scan reveals recent developed infiltrates.

 [1]: pending:yes
A 13 mer LNA-i-miR-221 Inhibitor Restores Drug Sensitivity in Melphalan-Refractory Multiple Myeloma Cells
Authors: Annamaria Gullà, Maria Teresa Di Martino, Maria Eugenia Gallo Cantafio, Eugenio Morelli, Nicola Amodio, Cirino Botta, Maria Rita Pitari, Santo Giovanni Lio, Domenico Britti, Maria Angelica Stamato, Teru Hideshima, Nikhil C. Munshi, Kenneth C. Anderson, Pierosandro Tagliaferri, Pierfrancesco Tassone
Journal: Clinical Cancer Research (2015)

The onset of drug resistance is a major cause of treatment failure in multiple myeloma. Although increasing evidence is defining the role of miRNAs in mediating drug resistance, their potential activity as drug-sensitizing agents has not yet been investigated in multiple myeloma.
Sole pulmonary involvement by Langerhans' cell histiocytosis in a child
Authors: J M Chatkin, J C Bastos, R T Stein, A M Gaiger
Journal: European Respiratory Journal (1993)

The case of a boy aged 4 yrs and 7 months, with isolated pulmonary involvement by Langerhans' cell histiocytosis is reported. The presentation of the disease was a sudden pneumothorax, with no previous signs of respiratory disease. The case was confirmed by S-100 and MT1 antibody staining, and was treated with pulse steroids and several pleural drainages, until the boy died after a large bilateral pneumothorax.
Profile of interstitial lung diseases in Pakistan, Karachi pulmonology clinics registry data, 2008 - 11
Authors: Mosavir Ansarie, Asif Naseem, Rashid Ahmed, Azeemuddin Muhammad
Journal: European Respiratory Journal (2012)

Background & Objective: No published data is available about the status of Interstitial Lung Diseases (ILD) in Pakistan. This study pioneers to determine the incidence and relative frequency of various ILDs in Karachi, its most populous multi-ethnic city.

Methods: We reviewed data from a registry catering to 3 pulmonology clinics in different areas of the city. Based on a detailed questionnaire it records age, gender, exposure history, clinical presentation, HRCT and PFT findings mandatorily and BAL/VATS data if available. It prospectively recorded diagnosed ILD cases between Jan 2008 and Dec 2011 and deaths occurring during follow-up.

Results: In a total of 5680 pulmonology referrals, the incidence of ILD was 2.3% (n=133) with a mean age of 55.1 years (+12.9 SD), mortality of 22.6% and median survival of 3 years. Idiopathic Pulmonary Fibrosis (IPF) (49.6%), Non Specific Interstitial Pneumonitis (NSIP) (19.5%) and Sarcoidosis (17.3%) were the most frequent ILDs followed by Collagen Vascular Disease Related (5.3%), Drug Induced ILD (4.5%) and Hypersensitivity Pneumonitis (3.8%). Reporting females (n=91) outnumbered males (n=42). The incidence of IPF/NSIP was greater in males (76%) while sarcoidosis and other ILDs occurred more in females (34%). Interestingly, out of 45 IPF diagnosed housewives living in congested areas, 42% had chronic avian exposure due to home breeding / pets.

Conclusion: The study establishes for the first time considerable presence of ILD in Pakistani population and describes its salient features. Hopefully this will improve disease awareness and help us expand this registry to other major cities for greater input towards research.
Influences of Age and Anatomical Site on Ultraviolet Carcinogenesis in BALB/c Mice&lt;xref ref-type="fn" rid="fn2"&gt;2&lt;/xref&gt;&lt;xref ref-type="fn" rid="fn3"&gt;3&lt;/xref&gt;
Authors: P Ebbesen, M L Kripke
Journal: JNCI Journal of the National Cancer Institute (1982)

Young adult BALB/c mice were mor susceptible to the induction of skin tumors from FS40 sunlamps than were 18-month-old animals. The relative contributions of tissue and host factors to this difference in susceptibility to carcinogenesis were analyzed by reciprocal grafting of skin between young and old animals, followed by repeated exposure of the grafts to UV radiation. More tumors developed in ear skin grafted to the middorsum of young recipients than in that of old recipients, regardless of the age of the skin donor. These ear skin grafts were more susceptible to tumor induction than were comparable grafts of back skin. When large areas of dorsal skin (16 cm2) were grafted to young adult mice, very old skin (greater than 2 yr) was more susceptible to tumor induction than skin that was 1 year old at the start of irradiation.
Sensory neuropeptides and the human lower airways: present state and future directions
Authors: GF Joos, PR Germonpre, JC Kips, RA Peleman, RA Pauwels
Journal: European Respiratory Journal (1994)

The sensory neuropeptides, substance P and neurokinin A, are present in human airway nerves, beneath and within the epithelium, around blood vessels and submucosal glands, and within the bronchial smooth muscle layer. Studies on autopsy tissue, bronchoalveolar lavage and sputum suggest that in asthma the substance P content of the airways may be increased. Neurokinin A is a more potent bronchoconstrictor than substance P. Asthmatics are hyperresponsive to neurokinin A and substance P. The neuropeptide degrading enzyme, neutral endopeptidase is present in the airways and is involved in the degradation of endogenously released and exogenously administered substance P and neurokinin A, both in normal and asthmatic subjects. As for other indirect bronchoconstrictor stimuli, the effect of neurokinin A on airway calibre in asthmatics can be inhibited by pretreatment with nedocromil sodium. Evidence is accumulating, not only from studies in animals but also from experiments on human airways, that tachykinins may also cause mucus secretion and plasma extravasation. They also have important proinflammatory effects, such as the chemoattraction of eosinophils and neutrophils, the adhesion of neutrophils, and the stimulation of lymphocytes, macrophages and mast cells. The tachykinins interact with the targets on the airways by specific tachykinin receptors. The NK1 and the NK2 receptor have been characterized in human airways, both pharmacologically and by cloning. The NK2 receptor is responsible for the in vitro contraction of normal airways, whilst the NK1 receptor is responsible for most of the other airway effects. Because of their presence in the airways and because of their ability to mimic the various pathophysiological features of asthma, substance P and neurokinin A are presently considered as possible mediators of asthma. The present development of potent and selective tachykinin antagonists will allow us to further define the role of tachykinins in the pathogenesis of asthma.
Chemoradiation for Locally Advanced Cervical Cancer: Does It Help?
Authors: Peter G. Rose, Brian N. Bundy
Journal: Journal of Clinical Oncology (2002)

Article Tools EDITORIALS Article Tools OPTIONS & TOOLS Export Citation Track Citation Add To Favorites Rights & Permissions COMPANION ARTICLES No companion articles ARTICLE CITATION DOI: 10.1200/JCO.2002.20.4.891 Journal of Clinical Oncology - published online before print September 21, 2016 PMID: 11844807 Chemoradiation for Locally Advanced Cervical Cancer: Does It Help? Peter G. RosexPeter G. RoseSearch for articles by this author , Brian N. BundyxBrian N. BundySearch for articles by this author Show More Case Western Reserve University, Cleveland, OH; Gynecologic Oncology Group Statistical Office, Roswell Park Cancer Institute, Buffalo, NY https://doi.org/10.1200/JCO.2002.20.4.891 First Page Full Text PDF Figures and Tables © 2002 by American Society of Clinical Oncology
A Phase I Trial of β-&lt;italic&gt;all-trans&lt;/italic&gt;-Retinoic Acid Delivered via a Collagen Sponge and a Cervical Cap for Mild or Moderate Intraepithelial Cervical Neoplasia&lt;xref ref-type="fn" rid="FN2"&gt;2&lt;/xref&gt;&lt;xref ref-type="fn" rid="FN3"&gt;3&lt;/xref&gt;
Authors: Frank L. Meyskens, Vivian Graham, Milos Chvapil, Robert T. Dorr, David S. Alberts, Earl A. Surwit
Journal: JNCI Journal of the National Cancer Institute (1983)

Journal Article A Phase I Trial of β-all-trans-Retinoic Acid Delivered via a Collagen Sponge and a Cervical Cap for Mild or Moderate Intraepithelial Cervical Neoplasia Get access Frank L. Meyskens, Jr., Frank L. Meyskens, Jr. Search for other works by this author on: Oxford Academic PubMed Google Scholar Vivian Graham, Vivian Graham Search for other works by this author on: Oxford Academic PubMed Google Scholar Milos Chvapil, Milos Chvapil Search for other works by this author on: Oxford Academic PubMed Google Scholar Robert T. Dorr, Robert T. Dorr Search for other works by this author on: Oxford Academic PubMed Google Scholar David S. Alberts, David S. Alberts Search for other works by this author on: Oxford Academic PubMed Google Scholar Earl A. Surwit Earl A. Surwit Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 71, Issue 5, November 1983, Pages 921–925, https://doi.org/10.1093/jnci/71.5.921 Published: 01 November 1983 Article history Received: 10 January 1983 Accepted: 27 May 1983 Published: 01 November 1983