tbuckley/cabot-search huggingface dataset:
Abstract 13586: Osteopontin RNA Aptamer Protects Against Pressure Overload-Induced Cardiac Dysfunction
Authors: Jihe Li, Paul Kurlansky, Lina A Shehadeh
Journal: Circulation (2013)

Objective:  Osteopontin (OPN) expression increases in the heart during hypertrophy and heart failure. OPN knockout mice subjected to pressure overload by trans-aortic constriction (TAC) were reported to have a reduced hypertrophic response. We hypothesized that use of an RNA aptamer targeting OPN protein would be an effective, cardiac-specific approach to modulating the hypertrophic response to overload stress.   Method and Results:  C57BL6 male mice were subjected to sham or TAC surgeries. TAC mice were injected with 2’OMe OPN RNA aptamer, 2’ OMe mutant OPN aptamer, or PBS. Each treated mouse received a total of 10 injections - one jugular injection during surgery, followed by 9 tail vein injections every other day. Cardiac function was measured by echocardiography at 4 and 6wks post TAC. At 4wks, the OPN aptamer group (n=13) showed increase in %EF (25%) and %FS (35%), and decrease in LVPWd (0.63 fold) - p   Conclusion:  OPN RNA aptamer protected against cardiac dysfunction in the mouse TAC model of cardiac hypertrophy. The cardioprotective effect of the OPN aptamer, together with the efficient uptake by cardiomyocytes make it a promising therapeutic molecule and a potential platform for targeted RNA delivery into the heart.
A novel homozygous keratin 14 mutation in a patient with autosomal recessive epidermolysis bullosa simplex and squamous cell carcinoma of the tongue
Authors: J.O. Baek, H.Y. Lee, S.W. Oh, J.S. Lee, S.C. Kim, J.R. Lee, J.Y. Roh
Journal: British Journal of Dermatology (2010)

Journal Article A novel homozygous keratin 14 mutation in a patient with autosomal recessive epidermolysis bullosa simplex and squamous cell carcinoma of the tongue Get access J.O. Baek, J.O. Baek Department of Dermatology, Gachon University of Medicine and Science, 1198 Kuwol‐dong, Namdong‐ku, Incheon 405‐760, Korea Search for other works by this author on: Oxford Academic Google Scholar H.Y. Lee, H.Y. Lee Department of Dermatology, Gachon University of Medicine and Science, 1198 Kuwol‐dong, Namdong‐ku, Incheon 405‐760, Korea Search for other works by this author on: Oxford Academic Google Scholar S.W. Oh, S.W. Oh Department of Dermatology and Cutaneous Biology Research Institute, Yonsei University College of Medicine, 35‐720 Eonjuro, Dogok‐dong, Gangnam‐ku, Seoul 135‐720, Korea Search for other works by this author on: Oxford Academic Google Scholar J.S. Lee, J.S. Lee Department of Dermatology and Cutaneous Biology Research Institute, Yonsei University College of Medicine, 35‐720 Eonjuro, Dogok‐dong, Gangnam‐ku, Seoul 135‐720, Korea Search for other works by this author on: Oxford Academic Google Scholar S.C. Kim, S.C. Kim Department of Dermatology and Cutaneous Biology Research Institute, Yonsei University College of Medicine, 35‐720 Eonjuro, Dogok‐dong, Gangnam‐ku, Seoul 135‐720, Korea Search for other works by this author on: Oxford Academic Google Scholar J.R. Lee, J.R. Lee Department of Dermatology, Gachon University of Medicine and Science, 1198 Kuwol‐dong, Namdong‐ku, Incheon 405‐760, Korea Search for other works by this author on: Oxford Academic Google Scholar J.Y. Roh J.Y. Roh Department of Dermatology, Gachon University of Medicine and Science, 1198 Kuwol‐dong, Namdong‐ku, Incheon 405‐760, Korea Joo‐Young Roh. E‐mail: jyroh1@gilhospital.com Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 162, Issue 4, 1 April 2010, Pages 880–882, https://doi.org/10.1111/j.1365-2133.2009.09614.x Published: 01 April 2010
Histopathology of childhood sarcomas, Intergroup Rhabdomyosarcoma Studies I and II: clinicopathologic correlation.
Authors: W A Newton, E H Soule, A B Hamoudi, H M Reiman, H Shimada, M Beltangady, H Maurer
Journal: Journal of Clinical Oncology (1988)

Histopathologic material from 1,782 patients registered in the Intergroup Rhabdomyosarcoma Study Committee (IRS)-I and -II were reviewed by the IRS Pathology Committee in order to provide a uniform approach to classification and correlate patient survival with tumor type. Categories considered eligible were the four types of rhabdomyosarcoma (RMS) (criteria of Horn and Enterline), extraosseous Ewing's tumor (EOE), and a group of somewhat variable undifferentiated sarcomas designated small round cell sarcoma, type indeterminate (STI). Tumors that were clearly sarcomas but were unclassifiable also were included (NOS). The committee diagnoses were embryonal (Emb) RMS in 877 (54%), alveolar (Alv) RMS in 343 (21%), botryoid (Botr) RMS in 88 (5%), pleomorphic (Pleo) RMS in 11 (1%), STI in 135 (8%), and EOE in 84 (5%). One in nine were mixtures of types, eg, Emb and Alv. Five percent of the sarcomas could not be classified because of inadequate material. In general, there was close agreement (94%) between the review committee and institutional pathologists in the diagnosis of RMS, but not in the specific types, particularly Alv RMS (41%) and STI (36%). This observation is important, since patients with Alv RMS and STI tumors had decreased survival compared with the other histologies. The prognosis varied by histology, with Botr having the best, Alv RMS and STI the worst, and Emb RMS and EOE an intermediate prognosis.
Predictive biomarker profiling of &gt; 1,900 sarcomas: Identification of potential novel treatment modalities.
Authors: Sujana Movva, Wenhsiang Wen, Wangjuh Chen, Sherri Z. Millis, Margaret von Mehren, Zoran Gatalica, Brian Andrew Van Tine
Journal: Journal of Clinical Oncology (2014)

10509 Background: Sarcomas are a heterogeneous group of tumors with > 50 subtypes. First line chemotherapy such as doxorubicin and ifosfamide yields limited survival benefit. New therapeutic options for sarcomas are needed; multiplatform profiling may provide potential targeted therapies. Methods: 1922 sarcomas were profiled using multiplatform biomarker assessment (Caris Life Sciences, Phoenix, AZ), including DNA sequencing (Sanger and next generation (NGS), Illumina MiSeq), gene copy variations and protein expression by immunohistochemistry. Results: Overexpression of TOPO2 and TOPO1 were observed in > 50% of sarcomas of various histopathologic types. Low MGMT expression was observed in 75% of osteosarcomas. Absence or low thymidine synthase (TS) expression was seen in Kaposi sarcoma, leiomyosarcomas (LMS), hemangiopericytomas and liposarcoma. PTEN loss was observed in up to 80% of subtypes including angiosarcoma, Kaposi sarcoma, LMS, liposarcoma, rhabdomyosarcoma, Ewing sarcoma, osteosarcoma, chondrosarcoma and others. cMET was amplified in 17 % of LMS; increased EGFR gene copies were detected in > 30% of malignant fibrous histiocytomas and malignant peripheral nerve sheath tumors. Of 281 patients tested using NGS, 137 mutations were detected in 24 genes (37%). TP53 was the most common (40%) followed by PIK3CA, PTEN, APC, KRAS, RB and ATM. TP53 mutations were associated with TOPO2 overexpression in 80% (p= 0.0003), with PTEN loss in 20% of patients (p=0.17) and with PIK3CA mutations in 2 patients (liposarcoma, LPS). Conclusions: Profiling of protein expression, gene copy variations and mutations identified clinically relevant alterations in 99% of sarcomas. Given the overexpression of TOPO2 in approximately 50% of sarcomas, its utility as a biomarker of sensitivity to anthracyclines should be studied, especially in relation to TP53 status in a tumor. Trials of agents like mTOR and PI3K inhibitors could benefit from designs in which patient selection is based on PTEN loss or PIK3CA mutations instead of sarcoma histology. The prognostic implications of the co-existence of TP53 mutations and PTEN loss in sarcomas is yet to be elucidated.
Can the Computer Assist Clinicians in Psychiatric Diagnosis?
Authors: ROBERT L. SPITZER, JEAN ENDICOTT
Journal: American Journal of Psychiatry (1974)

When 100 patients were evaluated by a therapist, DIAGNO III (a computer program for psychiatric diagnosis), and the senior author, the computer's and therapist's diagnoses were in agreement in 65 cases; the senior author's diagnoses agreed with the computer and therapist in 56 of the cases. The authors discuss the situations in which the computer can be most helpful in diagnosis and also point out some factors that reduce the potential of computer analysis. They suggest that despite the difficulties in computerizing data and in simulating the diagnostic process, computers can be of aid in the field of psychiatry as they have already proved to be in other medical specialties.
What Threshold for Adjuvant Therapy in Older Breast Cancer Patients?
Authors: Martine Extermann, Lodovico Balducci, Gary H. Lyman
Journal: Journal of Clinical Oncology (2000)

To consider the question of when to prescribe adjuvant treatment for elderly breast cancer patients, particularly when comorbidities are present. Knowledge of the threshold relapse risks above which adjuvant treatment is worth prescribing would enhance decision making.A Markov analysis of data from the medical literature was conducted. Patients aged 65 to 85 years were considered, along with three levels of comorbidity. The threshold risk of relapse at 10 years (RR10), at which time treatment provides absolute reduction or reduction of an absolute 1% in relapse or mortality, was evaluated.The threshold RR10 for an absolute reduction in mortality risk by adjuvant treatment was low through the age of 85 years. However, for an absolute 1% reduction, the effect of treatment on relapse and the effect of treatment on mortality increasingly diverged. The threshold RR10 for an absolute 1% reduction in relapse risk remained fairly low (5% to 6% for tamoxifen, 12% to 19% for chemotherapy). The threshold RR10 for an absolute 1% reduction in mortality risk, although starting close to the RR10 for an absolute 1% reduction in relapse risk, rose sharply. For tamoxifen, the difference between the two was 4% for an average 65-year-old, 6% at the age of 75 years, and 15% at the age of 85 years. For chemotherapy, the differences were 6%, 12%, and 30%, respectively. Similarly, thresholds increased with increasing comorbidity. In older and sicker patients, the maximum benefit was reached after 5 years rather than 10 years.Older breast cancer patients can expect a reduction in relapse that is fairly similar to that of younger patients. However, the effect on mortality diverges markedly, and attention should be paid to this difference in clinical decision making. Comorbidity should be considered in recommendations for adjuvant treatment, including clinical practice guidelines.
Electrogenic Cotransport of Na+, Sulfate (s-I) and Phosphate (p-I) in Xenopus Oocytes Expressing the Cloned Transport Proteins Nasi-1 and Napi-2
Authors: AE Busch, S Waldegger, T Herzer, G Hayes, J Biber, D Markovich, H Murer, F Lang
Journal: Kidney International (1995)
The Israeli public health response to wild poliovirus importation
Authors: Ehud Kaliner, Eran Kopel, Emilia Anis, Ella Mendelson, Jacob Moran-Gilad, Lester M Shulman, Shepherd R Singer, Yossi Manor, Eli Somekh, Shmuel Rishpon, Alex Leventhal, Lisa Rubin, Diana Tasher, Mira Honovich, Larisa Moerman, Tamy Shohat, Ravit Bassal, Danit Sofer, Michael Gdalevich, Boaz Lev, Ronni Gamzu, Itamar Grotto
Journal: The Lancet Infectious Diseases (2015)
Physiological phenotype and daily physical activity in COPD patients. A pilot study in Greece
Authors: Eleni Kortianou, Zafeiris Louvaris, Vasileios Andrianopoulos, Stavroula Spetsioti, Maroula Vasilopoulou, Marianneta Roumpani, Ioannis Vogiatzis
Journal: European Respiratory Journal (2012)

Background:  Although impaired lung function and skeletal muscle dysfunction impact on exercise intolerance and reduced physical activity in patients with COPD, there is limited available information on those phenotypic factors that determine real-life daily physical activity.   Aim:  The objective of this pilot study was to examine the impact of baseline lung dysfunction, exercise capacity and quadriceps muscle strength on daily walking movement intensity (WalkMI), walking energy expenditure (WalkEE) and average energy expenditure (AvgEE) in patients with COPD.   Methods:  20 COPD patients (age: 66±10; FEV 1 : 48±15 %predicted; FFMI: 18±3) were assessed using an incremental work-rate test, the 6MWT and quadriceps muscle force (QuadsMF). Physical activity was measured over 14 consecutive days using the DynaPort MoveMonitor triaxial accelerometer.   Results:  WalkMI was related to 6MWT (r=0.44, p=0.05) and inversely related to dyspnea sensations during the 6MWT (r=-0.56, p=0.009). WalkEE was positively related to peak oxygen uptake (r=0.57, p=0.009), peak work rate (r=0.59, p=0.006) and FEV 1  %predicted (r=0.52, p=0.017) and inversely related to dyspnea sensations during the 6MWT (r=-0.47, p=0.03). AvgEE expressed in Mets was related to QuadsMF adjusted by body weight (r=0.42, p=0.046) and inversely related to dyspnea sensations during the 6MWT (r=-0.53 p=0.017).   Conclusions:  Strategies to enhance whole body endurance capacity and locomotor muscle strength would ameliorate daily physical activities along with dyspnea sensations in patients with COPD.  Funded by the Innovative Medicine Initiative Joint Undertaking (IMI JU# 115011).
The prognostic significance of cardiopulmonary exercise in IPF
Authors: Christina Triantafillidou, Panagiotis Lyberopoulos, Likourgos Kolilekas, Konstantinos Kagouridis, Sotirios Gyftopoulos, Christina Sotiropoulou, Anastasia Kotanidou, Anna Karakatsani, Spyros Papiris
Journal: European Respiratory Journal (2011)

Background: In Idiopathic Pulmonary Fibrosis parenchymal lung damage leads to defects in mechanics and gas exchange, manifesting with progressive dyspnea and exercise limitation. Since IPF carries a poor prognosis, early and reliable prediction of survival is of significant value to the clinician. The role of maximal exercise data in prognostic evaluation of IPF patients is uncertain.

Aims and objectives: The aim of the present study was to evaluate the prognostic significance of cardiopulmonary exercise test (CPET) in this group of patients.

Methods: Twenty five IPF patients were prospectively recruited and underwent functional evaluation through maximal (CPET) and submaximal exercise testing (6 minute walk test- 6MWT) at diagnosis. Patients were followed up regularly; epidemiologic and survival data were gathered. Correlations between survival and parameters of maximal and submaximal exercise were calculated.

Results: Mean survival was 44.4 months.

![Figure][1] 



Statistically significant correlations were found between survival and CPET parameters such as VO2peak (p=0.02, RR=0.99), VO2peak/kg (p=0.01, R=0.78), AT (p=0.01, RR=0.72), SpO2peak (p=0.01, RR=0.8), VE/VCO2slope (p=0.005, RR=1.09), VE/VCO2AT (p=0.008, RR=1.14) and the 6MWT parameters: distance walked (p=0.008, RR=0.99) and desaturation (p=0.01, RR=1.42).

Conclusions: Physiological parameters obtained during maximal and submaximal exercise testing reflect survival in IPF population.

 [1]: pending:yes
Abstract 1581: Longitudinal 2-dimensional Strain Of Left Ventricle At Rest Predicts High Risk Coronary Artery Disease Without Regional Wall Motion Abnormality
Authors: Jin-Oh Choi, Seung Woo Park, Jeong Hoon Yang, Sung Won Cho, Soo Jin Cho, Sang Yeub Lee, Yong Whan Park, Sang-Chol Lee, Jidong Sung, June Soo Kim, Jeong Euy Park
Journal: Circulation (2007)

Objectives: Left main (LMD) and 3-vessel disease (3VD) are well-known risk factors for diagnostic stress test for coronary artery disease (CAD). However regional wall motions in those patients are frequently normal at resting status. We aimed to evaluate the segmental and global peak systolic longitudinal strain (PSLS) of left ventricle (LV) by 2D speckle tracking method and its usefulness as a screening method for high risk CAD. Methods: A total of 100 patients who underwent echocardiography and coronary angiography (CAG) were evaluated. Patients with regional wall motion abnormalities (RWMA), LV ejection fraction (EF) &lt;50%, valvular heart disease, atrial fibrillation or poor images were excluded. Echocardiographic examination including 2D strain analysis was performed and patients were grouped according to the results of CAG as following; LMD or 3VD as high risk group, 1- or 2-vessel disease as low risk group, and normal group. The global and segmental PSLS of basal, mid and apical LV were analyzed offline. Results: The PSLS of every segment of LV could be obtained successfully with good tracking quality in 88 (88%) patients. There were no significant differences in age, sex, blood pressure, and LV EF ( See Table ). The global and segmental PSLS of LV was significantly lower in high risk group compared with normal group. The mean PSLS of basal and mid LV was significantly reduced in high risk group compared with other groups. The receiver operational characteristic (ROC) curve demonstrated that the mid and basal PSLS could effectively predict high risk group (area under ROC curve=0.84, 95%CI=0.76~0.92). According to the ROC curve, −17.9% may be an optimal operational cut-off level to discriminate high risk group from others (specificity 79%, sensitivity 83%). Conclusions: Longitudinal 2D strain of LV at rest is significantly reduced in high risk CAD without RWMA and it might be useful for prediction of high risk before stress test. Clinical characteristics and peak systolic longitudinal strain
Fishing upstream: health and the social history
Authors: D. Loxterkamp
Journal: BMJ (2015)

The importance of determining the social determinants of health



It is now fashionable (even in the United States) for doctors to talk about social determinants of health. Polls show that access to healthy and affordable food, controlling drug misuse, and cleaning up the environment are seen as more important to people’s health than access to high quality medical care.1 Groups such as Health Leads train doctors to identify their patients’ social needs and to link them to community resources.2

Malcolm Gladwell introduced us to Million-Dollar Murray in 2006.3 Atul Gawande wrote about Jeff Brenner’s work among the “hot-spotters” of Camden, New Jersey, in 2011.4 Both sounded the alarm that unmet psychosocial needs have led to overuse of the healthcare system, largely because emergency departments and hospital wards have become society’s safety net. More recently, Rishi Manchada focused our attention on “upstream doctors” who look beyond the symptoms of disease to their source in the community.5 He estimated that the conditions under which people lived and worked had five times the impact on health and disease as all the pills and procedures in our medical quiver.

Of course, family …
Fecal microbiota transplantation in the management of hepatic encephalopathy
Authors: Dina Kao, Brandi Roach, Heekuk Park, Naomi Hotte, Karen Madsen, Vince Bain, Puneeta Tandon
Journal: Hepatology (2015)

Kao, Dina; Roach, Brandi; Park, Heekuk; Hotte, Naomi; Madsen, Karen; Bain, Vince; Tandon, Puneeta Author Information
The changes of serum adipocytokines levels in patients with OSAHS
Authors: Yong Lin, Ting Xu
Journal: European Respiratory Journal (2011)

Background:  Obstructive sleep apnea hypopnea is associated with obesity. Adipocytokines which were secretioned by fatty tissue can influence energy metabolism all over the body and development of obesity. Apelin, NPY and A-FABP were adipocytokines discovered for the past few years. They may participate the generation and development of OSHAS, especially obesity combined OSAHS.   Objective:  To investigate the relationship between adipocytokines (Apelin, NPY and A-FABP) and obstructive sleep apnea-hyperpnoea syndrome (OSAHS).   Methods:  Patients underwent polysomnography were recruited and divided into OSAHS group and non-OSAHS group. Each group was divided into obesity, hypergravity and normal body weight arms according BMI. OSAHS group was divided into mild, moderate and severe arms. Plasma Apelin, NPY, A-FABP (ng/ml) levels of all arms were tested and compared.   Results:  Plasma adipocytokines Apelin, NPY and A-FAPB levels were significantly higher in OSAHS group than in the non-OSAHS group of same weight, independent of age and gender. These adipocytokines plasma levels were positively correlated with AHI, BMI, while negatively correlated with LSaO 2  and MSaO 2  in OSAHS group.   Conclusions:  Obesity can cause the increase of plasma Apelin, NPY and A-FABP levels. These three adipocytokines were positively cforrelated with the severity degree of OSAHS.
Pharmacodynamic Evaluation of Switching From Ticagrelor to Prasugrel in Patients With Stable Coronary Artery Disease
Authors: Dominick J. Angiolillo, Nicholas Curzen, Paul Gurbel, Paul Vaitkus, Fred Lipkin, Wei Li, Joseph A. Jakubowski, Marjorie Zettler, Mark B. Effron, Dietmar Trenk
Journal: Journal of the American College of Cardiology (2013)
Study of open access centre for patients with breast cancer is planned
Authors: P. Kirkbride, K. Vallis
Journal: BMJ (1996)

Routine follow up ofbreast cancer in primary care Follow up by non-specialists should not be encouraged EDITOR,-While I welcome new initiatives in the management of breast cancer, I believe that the study by Eva Grunfeld and colleagues must be interpreted with caution.'The authors report no delay in the diagnosis of recurrent breast cancer or reduction in the quality of life of patients randomised to follow up by their general practitioner, but their conclusions must be questioned.The data on recurrence are based on a
Analysis of risk factors of recurrent tuberculosis in Han and Tibetan populations in Southwest China
Authors: Panwen Tian, Fuqiang Wen
Journal: European Respiratory Journal (2012)

Background:  Recurrent tuberculosis (TB) poses significant threats, including drug resistance, to TB control programs. However, the causes of TB recurrence, particularly in Southwest China, which is the high burden area, have not been well described.   Objectives:  To investigate the risk factors of recurrent TB, and analyze the differences between Han and Tibetan populations with TB recurrence in Southwest China.   Methods:  A population-based retrospective case-control study was carried out in Southwest China. All patients with culture-confirmed TB and drug susceptibility testing were included between 2000 and 2001 and followed until December 2010. Two category logistic regression was used in the statistical analysis.   Results:  We found that, among 80 patients (40 Han patients and 40 Tibetan patients) with recurrent TB who completed adequate therapy for a first episode of TB, factors independently associated with a greater risk of recurrent TB were not receiving directly observed therapy (HR 5.867, 95% CI 2.557-13.461), diabetes (HR 3.288, 95% CI 1.301-8.312), smoking (HR 2.387, 95% CI 1.328-4.291) and malnutrition (HR 1.910, 95% CI 1.110-3.285). The independent risk factors of recurrent TB for the Han patients included diabetes and smoking while the independent risk factors for the Tibetan patients included not receiving directly observed therapy and malnutrition.   Conclusions:  Our results establish that not receiving directly observed therapy, diabetes, smoking and malnutrition are associated with recurrent TB in Southwest China. To reduce the relapse rate of TB, especially for Tibetan populations, pursuing high-quality DOTS is essential.