SERUM URIC ACID IN RELATION TO AGE AND PHYSIQUE IN HEALTH AND IN CORONARY HEART DISEASE
Authors: M M GERTLER, S M GARN, S A LEVINE
Journal: Annals of Internal Medicine (1951)

Article1 June 1951SERUM URIC ACID IN RELATION TO AGE AND PHYSIQUE IN HEALTH AND IN CORONARY HEART DISEASEMENARD M. GERTLER, STANLEY M. GARN, SAMUEL A. LEVINE, F.A.C.P.MENARD M. GERTLER, STANLEY M. GARN, SAMUEL A. LEVINE, F.A.C.P.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-34-6-1421 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe disease most frequently associated with an abnormal uric acid metabolism is gout.1, 2This association is based upon deposits of uric acid in the joints and connective tissue of gouty patients, usually in the presence of hyperuricemia.3While the etiologic factors are unknown, it is generally agreed that the hyperuricemia is caused by endogenous factors in lieu of exogenous or renal factors. Additional observations which complicate the picture are: (a) the gouty diathesis may be present with4or without5an increase in the level of serum uric acid; (b) hyperuricemia occurs in families where gout has not been recognized.6...Bibliography1. BauerKlemperer WF: Gout, in Duncan, Diseases of metabolism, 2nd Ed., 1947, Chapter XII: 611-656 (Reprint). Google Scholar2. Jacobson BM: The uric acid in the serum of gouty and of non-gouty individuals: its determination by Folin's recent method and its significance in the diagnosis of gout, Ann. Int. Med. 11: 1277-1294, 1938. LinkGoogle Scholar3. Garrod AB: Observations on certain pathological conditions of the blood urine in gout, rheumatism and Bright's disease, Med. Chir. Tr. London 31: 83, 1848. CrossrefMedlineGoogle Scholar4. Roberts W: Allbutt's System of medicine, 1st Ed., 1900, The Macmillan Co., New York. Google Scholar5. 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GertlerGarnLerman MMSMJ: The interrelationship of serum cholesterol, cholesterol esters and phospholipids in health and in coronary artery disease, Circulation 2: 205-214, 1950. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Boston, Massachusetts*Received for publication February 1, 1950.From the Coronary Research Project, Massachusetts General Hospital and Harvard Medical School, Drs. P. D. White, H. B. Sprague, E. F. Bland, J. Lerman, S. A. Levine and E. A. Hooton, Directors. Supported by a grant from the Commonwealth Fund, New York City. 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Kannel, MD, and Daniel Levy, MDUric acid as a cardiovascular risk factor in arterial hypertensionSerum Uric Acid and Cardiovascular Events in Successfully Treated Hypertensive PatientsRelations of Hyperuricemia with the Various Components of the Insulin Resistance Syndrome in Young Black and White Adults: The CARDIA StudyCorrelates of uric acid and its association with asymptomatic carotid atherosclerosis: The ARIC studyHigh uric acid: A metabolic marker of coronary heart disease among alcohol abstainers?Effect of nibbling versus gorging on cardiovascular risk factors: Serum uric acid and blood lipidsInsulin resistance and risk factors for coronary heart diseasePrognose und Bedeutung der Hyperurikämie als Risikofaktor der koronaren HerzkrankheitDietary fiber and coronary heart diseaseHyperuricaemia and Risk of Cardiovascular Disease and Overall DeathWarfarin and Uric Acid after Myocardial InfarctionHuman physique and susceptibility to noninfectious diseaseHyperuricemia in the inhabitants of the marshall islandsSerum uric acid and coronary heart diseaseA controlled study of diet in patients with gout.Sulphinpyrazone and renal function following myocardial infarctionHyperuricemia as a Risk Factor for Cardiovascular MortalityHyperuricaemia and atherosclerosisThe relationship of serum uric acid to hypertension and ischemic heart disease in hisayama population, JapanThe relationship between high and low trait psychological stress and serum indicators of stressSelected Physiologic and Drug Effects on Serum Uric Acid Levels in an Elderly PopulationA COMPARATIVE STUDY OF PLATELET REACTIVITY IN ARTHRITIS*Uric acid in childhood essential hypertensionGout and pseudogout: Crystal-induced arthropathiesUric Acid Regulation in Hypertensive ChildrenPsychosomatic Aspects of GoutFactors influencing the serum uric acid level. 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