tbuckley/cabot-search huggingface dataset:
Outcome of multidrug resistant tuberculosis (MDR-TB) treatment with possible influencing factors
Authors: Tushar Sahasrabudhe, Vikas Oswal
Journal: European Respiratory Journal (2011)

It is important to know the outcome of MDR-TB treatment in a country, as many social and therapeutic factors may influence it. We have carefully kept longitudinal data of all MDR TB cases seen by us. The data of cases seen in last 10 years was analyzed to correlate these factors with the outcome. A total of 64 cases were evaluated. The mean age of diagnosis of TB was 28 years with a range of 13 to 65 years. The morbidity was long with a mean of 3.69 years. 30/64 (46.87%) patients had received DOTS as per the national programme.The mycobacteria were resistant to 5.66 drugs on an average. The patients averagely consulted 2.7 doctors for their treatment. 23/64 (35.93%) were lost to follow up. 4 are under treatment for less than 1 year. 7 patients are under treatment for more than 1 year out of which 5 (71.42%) show favorable response and 2 (28.57%) are still sputum positive. Remaining 30 patients had an outcome, out of which 25 (83.33%) got cured, 5 (16.66%) died. Those who defaulted fewer times had a better outcome (0.92defaults in cured patients as against 3.6 defaults in expired patients). 5.6 (28/5) regimens were used in expired patients whereas 3.36 (84/25) regimens were used in those who got cured. Single drug was added to a regimen 12 times in expired patients (2.4 times per patient) as against 12 times in cured patients (0.48 times per patient). Addition of single drug correlated with poorer outcome. Regimen was changed without doing mycobacterial culture 7 times in expired patients (1.4 times per patient) as against 13 times in cured patients (0.52 times per patient). This study highlights some factors in the management of MDR-TB that may help to achieve better outcome.
GPs must take some responsibility
Authors: D. R Chadwick
Journal: BMJ (1995)

EDITOR,—Richard Hobbs fails adequately to address two reasons, which he himself cites, for the increase in emergency admission—namely, raised expectations of general practitioners and worries over litigation.1 It would be difficult to argue that the rise in emergency admissions in recent years bears no relation to the increased demand for home visits by general practitioners, among other factors, as general practitioners pass on some of this workload to …
Bortezomib‐ and thalidomide‐induced peripheral neuropathy in multiple myeloma: clinical and molecular analyses of a phase 3 study
Authors: Paola Tacchetti, Carolina Terragna, Monica Galli, Elena Zamagni, Maria Teresa Petrucci, Annalisa Pezzi, Vittorio Montefusco, Marina Martello, Patrizia Tosi, Luca Baldini, Jacopo Peccatori, Miriana Ruggieri, Lucia Pantani, Antonio Lazzaro, Francesca Elice, Serena Rocchi, Alessandro Gozzetti, Guido Cavaletti, Antonio Palumbo, Michele Cavo
Journal: American Journal of Hematology (2014)

A subanalysis of the GIMEMA‐MMY‐3006 trial was performed to characterize treatment‐emergent peripheral neuropathy (PN) in patients randomized to thalidomide‐dexamethasone (TD) or bortezomib‐TD (VTD) before and after double autologous transplantation (ASCT) for multiple myeloma (MM). A total of 236 patients randomized to VTD and 238 to TD were stratified according to the emergence of grade ≥2 PN. Gene expression profiles (GEP) of CD138+ plasma cells were analyzed in 120 VTD‐treated patients. The incidence of grade ≥2 PN was 35% in the VTD arm and 10% in the TD arm ( P &lt; 0.001). PN resolved in 88 and 95% of patients in VTD and TD groups, respectively. Rates of complete/near complete response, progression‐free and overall survival were not adversely affected by emergence of grade ≥2 PN. Baseline characteristics were not risk factors for PN, while GEP analysis revealed the deregulated expression of genes implicated in cytoskeleton rearrangement, neurogenesis, and axonal guidance. In conclusion, in comparison with TD, incorporation of VTD into ASCT was associated with a higher incidence of PN which, however, was reversible in most of the patients and did not adversely affect their outcomes nor their ability to subsequently receive ASCT. GEP analysis suggests an interaction between myeloma genetic profiles and development of VTD‐induced PN. Am. J. Hematol. 89:1085–1091, 2014. © 2014 Wiley Periodicals, Inc.
Making Medicine Scientific: John Burdon Sanderson and the Culture of Victorian Science
Authors: L. M. Barnett
Journal: JAMA (2003)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Abstract 14348: Percutaneous Transluminal Angioplasty for Peripheral Artery Disease Immediately Confers Cardioprotection by Reducing the Carotid Augmentation Index
Authors: Atsubumi Murakami, Kazuo Eguchi, Akio Kawasaki, Koji Ogata, Hiroshi Miyashita, Kazuomi Kario
Journal: Circulation (2010)
Medical aspects of fitness to drive
Authors: D E Morris
Journal: BMJ (1995)

Data from transnational study of oral contraceptives have been misusedEDITOR,-The unpublished data from the transnational study of oral contraceptives have been misused and misinterpreted in Britain because of inexplicable haste and urgency not thought necessary by other major regulatory agencies.My col- leagues and I do not agree that our findings justify the drastic actions taken in Britian, whereby a "Dear Doctor" letter was sent to doctors, warning that oral contraceptives containing desogestrel and gestodene are associated with an increased risk of thromboembolism (pp 1112, 1117, and 1172).1 Doctors should be vigilant but not stampeded.
Abstract 1932: Bleeding and Vascular Complications Following Percutaneous Coronary Intervention can be Reduced with Multiple Practice Changes
Authors: John F Robb, Arvind K Sharma, David J Malenka, Winthrop D Piper, Sheila M Conley, Bruce J Freidman, Bruce D Hettleman, John E Jayne, Nathaniel W Niles, Craig A Thompson, Aaron V Kaplan
Journal: Circulation (2007)

Background : Bleeding (BC) and vascular complications (VC) remain an important cause of post-PCI morbidity and mortality that are potentially avoidable. We implemented a series of practice changes to reduce the risk of BC and VC and hypothesized they would be significantly associated with a decreased risk of these adverse events. Method s: Data were prospectively collected on 5916 consecutive patient admissions comprising 6019 PCIs from 1/2002–9/2006 at the Dartmouth-Hitchcock Medical Center. During that time period practice changes included routine fluoroscopy-guided femoral puncture, routine femoral angiography, selective use of closure devices, increased use of bivalirudin, decreased use of IIb/IIIa inhibitors, use of a dedicated recovery unit. Logistic regression was used to examine the relationship between changing practices, BC, and VC, controlling for case-mix, with results reported as adjusted odds ratios (OR) with 95% confidence intervals. Results: Between 2002 and 2006 BC rates decreased from 5.95% to 4.42% (p=0.006) and VC rates from 0.47% to 0.09% (p=0.070). The risk of BC decreased significantly with the use of bivalirudin, femoral angiography, suture-mediated closure, and use of a recovery unit (Table ). VC decreased significantly with the use of closure devices. Conclusions: Procedural and process changes made in the care of patients undergoing PCI were significantly associated with decreasing the risk of BC and VC. Adjusted * Odds Ratios for Bleeding and Vascular Complications: Treatment and Process Variables
On editing the Journal: Ave atque vale
Authors: F J Braceland
Journal: American Journal of Psychiatry (1978)

Dr. Braceland discusses his 13-year tenure (1965-1978) as Editor of the American Journal of Psychiatry, noting that he took office during a period of social turmoil that in many ways resembled the decade of the Journal's founding 134 years ago. He describes the advantages and disadvantages of the peer review system he introduced to the Journal and states that this approach is essential in a time of ultraspecialization. He reviews the crafts of editing and writing for medical journals, both of which are brightened by clarity and brevity. As to the future of medical journals, he considers reports of their demise premature, while acknowledging the problems they face. Dr. Braceland briefly considered a "rocking chair" approach to his retirement from the Editorship, but the Editor Emeritus will instead continue to provide whatever assistance he can to his colleagues.
Abstract 83: Preconditioning With Periodic Acceleration (pGz) Prior To Whole Body Ischemia Reperfusion Injury Ameliorates Myocardial Stunning And Arrhythmias
Authors: Jose A Adams, Jorge Bassuk, Heng Wu, Jaqueline Arias, Dongmei Wu, Vinod Jorapur, Gervasio Lamas, Paul Kurlansky
Journal: Circulation (2007)

Periodic acceleration (pGz) consists of sinusoidal, head to foot motion of the supine body achieved with a motion platform. pGz produces pulsatile shear stress on the vascular endothelium in vivo a...
Long-term psychological effects of rape in 35 rape victims
Authors: Jose M. Santiago, Fred McCall-Perez, Michele Gorcey, Allan Beigel
Journal: American Journal of Psychiatry (1985)

Thirty-five rape victims who had been assaulted from 2 to 46 years earlier were interviewed to determine the long-term effects of sexual assault. Victims were compared to 110 nonabused matched control subjects on their scores on the State-Trait Anxiety Inventory, the Beck Depression Inventory, and the modified Fear Survey Interview. An analysis was also conducted to determine which of the factors characterizing the rape situation had an influence on the victims' scores. Rape victims were found to be significantly more depressed, generally anxious, and fearful than control subjects. Only one rape situation variable, the survivor having been a prior victim of sexual assault, was found to be related to a higher degree of depression and anxiety.
Abstract 3001: Assessment Of Ethnic Differences In The Left Ventricular Remodelling In Elite Athletes
Authors: Sandeep Basavarajaiah, Lorna Carby, Arash Yavari, Anupama Nandagudi, Gordon Jackson, Gregory Whyte, Ajay Shah, Sanjay Sharma
Journal: Circulation (2007)

Objectives: The upper limits of physiologic increase in the left ventricular (LV) dimensions for the purposes of differentiation from cardiomyopathies are well established in Caucasian athletes. However, there are few data regarding the physiologic LV remodelling in black athletes (BA) in whom deaths from cardiomyopathies are more prevalent. Methods: Between 2005 and 2006, 200 asymptomatic and normotensive black (African/AfroCaribbean) male athletes (mean age: 20.5 ± 5.80; range 14 –35 years and a mean BSA: 1.94 ± 0.16 m 2 ; range1.36 –2.29) underwent 12-lead EKG and 2-D echocardiography. The results were compared to those of 100 black controls (BC) and 200 highly trained white male athletes matched for age, size, sport and training programs. None of them had a family history of cardiomyopathy. Cardiac dimensions and function were measured in accordance using conventional methods. Results: The LV dimensions of black athletes (BA) compared with black controls (BC) and WA are shown below Data expressed as mean ± standard deviation (range) LVWTd- left ventricular wall thickness in end diastole LVIDd- left ventricular internal dimensions in end diastole Both BA and WA had a greater LV dimensions than BC. Black athletes had greater LVWT than WA amounting to a difference of 11%. In absolute terms, 40 (20%) BA had a LVWT &gt; 12 mm compared with 12 (6%) WA. There were no significant differences in the LV cavity size or indices of diastolic function between BA and WA. All BA with a LVWT &gt; 12 mm had an enlarged LV cavity size and normal indices of diastolic function indicating physiologic left ventricular hypertrophy (LVH) rather than hypertrophic cardiomyopathy (HCM). Conclusion: •Black athletes develop modest increase in the LV dimensions as compared to BC. •The magnitude of LVH in BA is significantly greater than in WA. •More BA have absolute LVWT values in the region compatible with morphologically mild HCM. •Our study calls for a separate physiologic upper limits for LV dimensions in BA.
Erectile Dysfunction and Later Cardiovascular Disease in Men With Type 2 Diabetes
Authors: G. David Batty, Qiang Li, Sébastien Czernichow, Bruce Neal, Sophia Zoungas, Rachel Huxley, Anushka Patel, Bastiaan E. de Galan, Mark Woodward, Pavel Hamet, Stephen B. Harrap, Neil Poulter, John Chalmers
Journal: Journal of the American College of Cardiology (2010)
GLYCOGEN FORMATION IN DIABETES
Authors: F. D. W. Lukens
Journal: Annals of Internal Medicine (1934)

Article1 December 1934GLYCOGEN FORMATION IN DIABETESF. D. W. LUKENSF. D. W. LUKENSSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-8-6-727 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptDuring the past two years observations on the behavior of muscle glycogen have been made by Dr. C. N. H. Long and the author1 at the University of Pennsylvania. The breakdown and recovery of muscle glycogen, following exercise, in normal and depancreatized animals has been directly studied and certain aspects of the formation of glycogen in the absence of insulin have been analyzed. These results will be briefly outlined and their relation to our present concepts of the mechanism of glycogen regulation in diabetes will be considered.Since muscle glycogen comprises the largest amount of carbohydrate stored in the body,...References1 LONGLUKENSFRY CNFDEG: Glycogen resynthesis in depancreatized animals, Jr. Biol. Chem., 1934, xv, lii. Google Scholar2. CLEGHORNPETERSON RAJM: Reappearance of glycogen in muscles of decerebrate cat after its removal during tetanic contraction, Jr. Physiol., 1932, lxxiv, 338-342. CrossrefGoogle Scholar3. PESERICO E: Il glicogeno muscolare del cane diabetico nel lavoro e nel riposo, Arch. di fisiol. (supp.), 1926, xxiv, 708-729. Google Scholar4. MILROY TH: Recovery process after fatigue of mammalian skeletal muscle in normal and in diabetic animal, Quart. Jr. Exper. Physiol., 1927, xvii, 161-177. CrossrefGoogle Scholar5. DEBOIS G: Glycopexie musculaire après injection de glucose. Rôle des nerfs vagues, Arch. internat. de pharmacodyn. et de thérapie, 1931, xli, 129-144. Google Scholar6. MAJORMANN SGFC: Formation of glycogen following pancreatectomy, Am. Jr. Physiol., 1932, cii, 409-421. CrossrefGoogle Scholar7. LONGHORSFALL CNFL: Recovery process after exercise in the mammal; conversion of infused d-lactic acid into muscle glycogen, Jr. Biol. Chem., 1932, xcv, 715-733. CrossrefGoogle Scholar8. MACLEOD JJ: The control of carbohydrate metabolism, Bull. Johns Hopkins Hosp., 1934, liv, 79-139. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Philadelphia, Pennsylvania*Read at the Chicago meeting of the American College of Physicians, April 18, 1934.From the George S. Cox Medical Research Institute, University of Pennsylvania. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byOn the Mechanisms of Action of Hormones on CellsCurrent views on the mechanisms of insulin actionStoffwechsel der KohlenhydrateÜber die Beeinflussung des Kh.-Stoffwechsels der Leber Durch LeberextraktPreparation of the jaundiced patient for operationInsulin 1 December 1934Volume 8, Issue 6Page: 727-733KeywordsBehaviorCarbohydratesExerciseGlycogensInsulinMuscles ePublished: 1 December 2008 Issue Published: 1 December 1934 PDF downloadLoading ...
Development of a tool for reversed-phase protein microarrays (RPMA) and use in immunoproteomics of breast cancer
Authors: K. Keller, D. Boehm, A. Lebrecht, M. Schmidt, H. Koelbl, F. Grus
Journal: Journal of Clinical Oncology (2009)

e22186 Background: Breast cancer is the most commonly diagnosed cancer type in women and one of the most frequent types of cancer which leads to death. It´s early detection is a key factor for successful treatment of patients. Besides, most of the current biomarkers are still lacking of specificity. In the past decade cancer immunogenicity has been described. A development of a new non-invasive method for the detection of humoral response to cancer would be of great benefit. Methods: The proteins from healthy breast tissue and carcinoma were extracted and separated via sodium dodecylsulfate polyacrylamide gel electrophoresis. The non-stained proteins were cut out of gel, digested with trypsin and spotted on nitrocellulose microarray slides. Each sub array was incubated either with different sera of breast cancer patient or with control sera and afterwards labelled with a cyanine 5-labelled human anti-immunoglobulin G antibody (IgG). Results: The extracted and digested protein fractions from both tissue types showed reproducible antibody profiles after the incubation with sera and labelling with anti-IgG antibody. The intensity of the detected signals varied within different protein fractions. Conclusions: This method provides a stable, simple and reproducible visualization of specific antibody profiles. Further upgrading of this method could facilitate a development of a fast, non-invasive and cost- efficient tool for immunoproteomics of cancer. Moreover, the following subsequent identification of the involved tumor associated antigens (TAA´s) is crucial for an understanding of their role in pathogenesis and cancer development, possibly leading to design of new cancer therapies. No significant financial relationships to disclose.
Hybrid pulmonary surfactant-coated nanogels mediate efficient in vivo delivery of siRNA to murine alveolar macrophages
Authors: Lynn De Backer, Thomas Naessens, Stefaan De Koker, Elisa Zagato, Jo Demeester, Johan Grooten, Stefaan C De Smedt, Koen Raemdonck
Journal: Journal of Controlled Release (2015)
Screening for osteoporosis
Authors: I. Fogelman
Journal: BMJ (1999)

For the middle aged physician it may come as a shock to learn that it is not only little old ladies with curved backs who have osteoporosis. The currently accepted definition of this condition is “a systemic skeletal disorder characterised by low bone mass and microarchitectural deterioration of bone tissue, with a consequent increase in bone fragility and susceptibility to fracture.”1 This definition introduces the concept of low bone mass and its relation to increased fracture risk but does not require fracture to have occurred. There is some logic to this, in as much as there are no symptoms of osteoporosis before fracture, which occurs late in the disease; most hip fractures, for example, occur in people aged over 80 with associated high morbidity and mortality. It is therefore desirable to identify those individuals at greatest risk because that risk can be roughly halved with effective treatment.2

The introduction of bone density measurements, and in particular dual x ray absorptiometry (DXA), has revolutionised the whole field of osteoporosis, and it is well established that bone mineral density provides the best means of assessing an individual's risk of fracture, with every reduction of 1 standard deviation in bone density equating to a roughly 2-2.5 fold increase in the likelihood of fracture.3 Bone mineral density …
More Healthy People in the 21st Century?
Authors: M J Friedrich
Journal: JAMA (2000)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Abstract 1535: PB1 Domain Mediated PKCz and p62 Interaction Regulates Flow-Induced ERK5 Activation
Authors: Gwenaele garin, Junichi Abe, Chen Yan, Weimin Liu, Andrew Newby, Arshad Rahman, Bradford Berk
Journal: Circulation (2006)

ERK5 mediates several flow-dependent endothelial cell (EC) functions including cell survival and gene expression. The upstream regulators of ERK5 stimulated by flow are poorly characterized. A prot...