LABORATORY AND CLINICAL EXPERIENCE WITH SODIUM GENTISATE IN RHEUMATIC DISEASE
Authors: E F ROSENBERG, D A KREVSKY, B M KAGAN
Journal: Annals of Internal Medicine (1952)

Article1 June 1952LABORATORY AND CLINICAL EXPERIENCE WITH SODIUM GENTISATE IN RHEUMATIC DISEASEEDWARD F. ROSENBERG, M.D., F.A.C.P., DAVID A. KREVSKY, M.D., B. M. KAGAN, M.D., F.A.C.P.EDWARD F. ROSENBERG, M.D., F.A.C.P.Search for more papers by this author, DAVID A. KREVSKY, M.D.Search for more papers by this author, B. M. KAGAN, M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-36-6-1513 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptGentisic acid, 2,5-dihydroxybenzoic acid, C6H3-(OH)2COOH, has been isolated from the urine of human subjects following administration of sodium salicylate.1Recent studies have shown that this compound in dilute solutions exerts a powerful inhibiting effect on the action of the enzyme hyaluronidase. Salicylic acid solutions also inhibit the action of the enzyme, but only in relatively high concentrations.2This action of gentisic acid stimulated research into the effectiveness of this compound as a therapeutic agent in rheumatic diseases. Studies reported by Meyer and Ragan3suggested that one possible mechanism of pathogenesis in rheumatic diseases may be the breakdown of interfibrillar cement...Bibliography1. KappCoburn EMAF: Urinary metabolites of sodium salicylate, J. Biol. Chem. 145: 549-565, 1942. CrossrefGoogle Scholar2. Guerra F: The action of sodium salicylate and sulfadiazine on hyaluronidase, J. Pharmacol. and Exper. Therap. 87: 193-197, 1946. MedlineGoogle Scholar3. MeyerRagan KC: Hyaluronic acid and the rheumatic diseases, Mod. Concepts Cardiovas. Dis. 17: No. 2, 1948. MedlineGoogle Scholar4. MeyerRagan KC: The antirheumatic effect of sodium gentisate, Science 108: 281, 1948. CrossrefMedlineGoogle Scholar5. CamelinOccoyerPelleratLafumaCoirault APJJR: Action du gentisate de sodium dans la maladie de Bouillaud. Premiers essais cliniques, Bull. et mém. Soc. méd. d. hôp. de Paris 65: 826-832, 1949. MedlineGoogle Scholar6. SchaeferRashkoffMegibow LEIARS: Sodium gentisate in the treatment of acute rheumatic fever, Circulation 2: 265-270, 1950. CrossrefMedlineGoogle Scholar7. BattermanKyleDann RCLSS: The analgesic action of sodium gentisate, New York State J. Med. 51: 1152-1154, 1951. MedlineGoogle Scholar8. BarbourFisk HGME: Liver damage in dogs and rats after repeated oral administration of cinchophen, ethyl ester of paramethyl-phenylcinchoninic acid (Tolysin) and sodium salicylate, J. Pharmacol. and Exper. Therap. 48: 341-357, 1933. Google Scholar9. Ozu M: Influence of sodium salicylate, aniline and picrotoxin on blood sugar of rabbits, Chem. Abstr. 38: 6385, 1944. Google Scholar10. Lutwak-Mann C: The excretion of a metabolic product of salicylic acid, Biochem. J. 37: 246-248, 1943. CrossrefMedlineGoogle Scholar11. GeraldKagan PSBM: A method for the determination of gentisic acid in serum, J. Biol. Chem. 189: 467-472, 1951. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: *Received for publication January 18, 1952.From the Kunstadter Laboratories for Pediatric Research, the Sarah Morris Hospital for Children and the Department of Medicine, Michael Reese Hospital, Chicago, Illinois.This study was aided by a grant from The Wm. S. Merrell Company, Cincinnati, Ohio. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byA new sensor based on an amino-montmorillonite-modified inkjet-printed graphene electrode for the voltammetric determination of gentisic acidAcetylsalicylic acid and its metabolite gentisic acid may act as adjunctive agents in the treatment of psychiatric disordersSome characteristics of the prostaglandin synthesizing system in rabbit kidney microsomesImportance of sulfhydryl groups for the uncoupling activity of non-steroidal acidic anti-inflammatory drugs and valinomycin in oxidative phosphorylationTHE EFFECT OF NON-STEROIDAL ANTI-INFLAMMATORY DRUGS ON HISTAMINE FORMATION IN THE RAT2 Non-Steroidal Anti-Inflammatory DrugsBiochemical properties of anti-inflammatory drugs—VSome Biochemical and Pharmacological Properties of Anti-Inflammatory DrugsBiochemical properties of anti-inflammatory drugs—III.Krankheiten der Knochen, Gelenke und Muskeln 1 June 1952Volume 36, Issue 6Page: 1513-1519KeywordsChildrenClinical laboratoriesEnzymesHospital medicinePathogenesisResearch laboratoriesSalicylatesSodiumUrine ePublished: 1 December 2008 Issue Published: 1 June 1952 PDF downloadLoading ...