RADIATION INJURY AND MARROW REPLACEMENT: FACTORS AFFECTING SURVIVAL OF THE HOST AND THE HOMOGRAFT
Authors: J W FERREBEE, E D THOMAS
Journal: Annals of Internal Medicine (1958)

Article1 November 1958RADIATION INJURY AND MARROW REPLACEMENT: FACTORS AFFECTING SURVIVAL OF THE HOST AND THE HOMOGRAFTJOSEPH W. FERREBEE, M.D., E. DONNALL THOMAS, M.D., F.A.C.P.JOSEPH W. FERREBEE, M.D.Search for more papers by this author, E. DONNALL THOMAS, M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-49-5-987 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptINTRODUCTIONExposure of the entire body to ionizing radiation†in the range of 500 to 1,000 Roentgens (r) is followed by death in from seven to 14 days.1A failure of marrow function is the primary cause of this death, and the symptoms are primarily those of bleeding and septicemia. In a number of animal species—mice,2rats, rabbits,3dogs,4monkeys,5and chimpanzees6—death of this type can be avoided by the intravenous infusion of homologous marrow cells‡a day or two after the exposure to radiation. The infused marrow cells "home" to their appropriate sites in the marrow of...Bibliography1. Davidson HO: Biological effects of whole-body gamma radiation on human beings, 1957, Johns Hopkins Press, Baltimore. Google Scholar2. Congdon CC: Experimental treatment of total-body irradiation injury: a brief review, Blood 12: 746, 1957. CrossrefMedlineGoogle Scholar3. Porter KA: Effect of homologous bone marrow injections in x-irradiated rabbits, Brit. J. Exper. Path. 38: 401, 1957. MedlineGoogle Scholar4. FerrebeeLochteJaretzkiSahlerThomas JWHLAODED: Successful marrow homografts in the dog after radiation, Surgery 43: 516, 1958. MedlineGoogle Scholar5. CrouchOverman BGRR: Whole-body radiation protection in primates, Federation Proc. 16: 27, 1957. Google Scholar6. RothbergAkeroyd HJ: Observations on chimpanzees after whole body radiation and homologous bone marrow treatment, Clin. Res. 6: 207 (Apr.) 1958. Google Scholar7. ThomasLochteLuFerrebee EDHLWCJW: Intravenous infusion of bone marrow in patients receiving radiation and chemotherapy, New England J. Med. 257: 401, 1957. CrossrefGoogle Scholar8. ThomasLochteFerrebee EDHLJW: Irradiation of the entire body and marrow transplantation (some observations and comments), Blood, in press. Google Scholar9. HumbleNewton JGKA: Technique of human bone marrow transplants, Lancet 1: 142, 1958. CrossrefMedlineGoogle Scholar10. FerrebeeBillenUrsoLuThomasCongdon JWDIMWCEDCC: Preservation of radiation recovery factor in frozen marrow, Blood 12: 1096, 1957. CrossrefMedlineGoogle Scholar11. FerrebeeAtkinsLochteMcFarlandJonesDamminThomas JWLHLRBARGJED: The collection, storage, and preparation of viable cadaver marrow for intravenous use, submitted to Blood, May, 1958. Google Scholar12. Transactions of 1st, 2nd and 3rd Tissue Homotransplantation Conferences, New York Academy of Science, 1955, 1956, 1958. Google Scholar13. FerrebeeMerrill JWJP: Spare parts: a review with a forward look, Surgery 41: 503, 1957. MedlineGoogle Scholar14. BillinghamBrentMedawar RELPB: Quantitative studies on tissue transplantation immunity. III. Actively acquired tolerance, Phil. Trans. Roy. Soc. London 239: 357, 1956. Google Scholar15. FordHamertonBarnesLoutit CEJLDWJF: Cytological identification of radiation-chimeras, Nature, London 177: 452, 1956. CrossrefMedlineGoogle Scholar16. Ferrebee JW: Editorial, "Spare parts," New England J. Med. 257: 524 (Sept. 12) 1957. CrossrefMedlineGoogle Scholar17. BurnetFenner FMF: The production of antibodies, 1949, The Macmillan Co., Melbourne. Google Scholar18. Owen RD: Growth inhibition by analogues of pantothenic acid. II. α-and β-substituted pantothenic acids and related compounds, Science 102: 400, 1945. CrossrefMedlineGoogle Scholar19. Simonsen M: The acquired immunity concept in kidney homotransplantation, Ann. New York Acad. Sc. 59: 448, 1955. CrossrefMedlineGoogle Scholar20. BillinghamBrentMedawar RELPB: The antigenic stimulus in transplantation immunity, Nature, London 178: 514, 1956. CrossrefMedlineGoogle Scholar21. MainPrehn JMRT: Successful skin homografts after the administration of high dosage x-radiation and homologous bone marrow, J. Nat. Cancer Inst. 15: 1023, 1955. MedlineGoogle Scholar22. NowallColeRoanHabermeyer PCLJPLJG: Distribution and in situ growth pattern of injected rat marrow in x-irradiated mice, J. Nat. Cancer Inst. 18: 127, 1957. MedlineGoogle Scholar23. ThomasLochteJaretzkiAshleySahlerFerrebee EDHLACAODJW: Homografts of bone marrow in dogs after lethal total-body radiation, paper presented at the meeting of the American Society for Clinical Investigation, Atlantic City, New Jersey, May 4, 1958. Google Scholar24. DavidsonSmith WMDR: A morphological sex difference in the polymorphonuclear neutrophil leucocytes, Brit. M. J. 2: 6, 1954. CrossrefMedlineGoogle Scholar25. CongdonMakinodanGengozianShekarchiUrso CCTNICIS: Lymphatic tissue changes in lethally irradiated mice given spleen cells intravenously, J. Nat. Cancer Inst., in press. Google Scholar26. MakinodanGengozianShekarchi TNIC: Relative effects of splenic and bone marrow cells on lethally irradiated mice, J. Nat. Cancer Inst. 20: 591, 1958. MedlineGoogle Scholar27. MakinodanGengozianCongdon TNCC: Agglutinin production in normal, sublethally irradiated, and lethally irradiated mice treated with mouse bone marrow, J. Immunol. 77: 250, 1956. MedlineGoogle Scholar28. CosgroveSchwartzUptonCongdon GEEEACCC: Changes in irradiated F1 hybrid mice injected with parenteral spleen cells, Federation Proc. 17: 434, 1958. Google Scholar29. Uphoff DE: The preclusion of secondary phase of irradiation syndrome by inoculation of fetal hematopoietic tissue following lethal total-body x-irradiation, J. Nat. Cancer Inst. 20: 625, 1958. MedlineGoogle Scholar30. AlpenBaum ETSJ: Acute radiation protection in dogs by bone marrow auto transfusions, Meeting of Radiation Research Society, Rochester, New York, May 13-15, 1957. Google Scholar31. AlpenBaum ETSJ: Personal communication. Google Scholar32. Merrill JP: Personal communication. Google Scholar33. Main J: Personal communication, paper in press, J. Nat. Cancer Inst. Google Scholar34. Thomas ED: In vitro studies of erythropoiesis. I. Effect of normal serum on heme synthesis and oxygen consumption by bone marrow, Blood 10: 600, 1955. CrossrefMedlineGoogle Scholar35. SchwartzRepplingerCongdonTocantins IREFCCLM: Transplantation of bone marrow after preservation at -70° C., J. Appl. Physiol. 11: 22, 1957. CrossrefMedlineGoogle Scholar36. UrsoCongdon PCC: The effect of the amount of isologous bone marrow injected on the recovery of hematopoietic organs, survival and body weight after lethal irradiation injury in mice, Blood 12: 251, 1957. CrossrefMedlineGoogle Scholar37. BarnesCorpLoutitNeal DWMJJFFE: Treatment of murine leukemia with x-rays and homologous bone marrow, Brit. M. J. 2: 626, 1956. CrossrefMedlineGoogle Scholar38. BarnesLoutit DWJF: Treatment of murine leukemia with x-rays and homologous bone marrow. Part II., Brit. J. Haematol. 3: 241, 1957. CrossrefMedlineGoogle Scholar39. Johns HE: X-rays and teleisotope gamma rays, in Hine, G. J., and Brownell, G. L.: Radiation dosimetry, 1956, Academic Press, Inc., New York, pp. 532-594. CrossrefGoogle Scholar40. Spiers FW: The influence of energy absorption and electron range on dosage in irradiated bone, Brit. J. Radiol. 22: 521, 1949. CrossrefMedlineGoogle Scholar41. Trentin JJ: Mortality and skin transplantability in x-irradiated mice receiving isologous, homologous or heterologous bone marrow, Proc. Soc. Exper. Biol. and Med. 92: 688, 1956. CrossrefMedlineGoogle Scholar42. Tocantins LM: Personal communication. Google Scholar43. Andrews G: Personal communication. Google Scholar44. McIlvanie SK: Personal communication. Google Scholar45. Atkinson JB: Personal communication. Google Scholar46. FerrebeeThomas JWED: Factors affecting the survival of transplanted tissues, Am. J. M. Sc. 235: 369, 1958. CrossrefMedlineGoogle Scholar47. StroudBrues ANAM: Plasma protein fractions protecting mice against irradiation, Federation Proc. 13: 147, 1954. Google Scholar48. DonaldsonMiller DMML: Inhibition of normal serum bactericidal activity by nitrogen mustard, Federation Proc. 17: 509, 1958. Google Scholar49. Howland JW: Radioactivity: injury and recovery from ionizing radiation exposure, Ann. Rev. Med. 7: 225, 1956. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Cooperstown, N. Y.*Presented as a Morning Lecture at the Thirty-ninth Annual Session of The American College of Physicians, Atlantic City, New Jersey, May 1, 1958.Requests for reprints should be addressed to Joseph W. Ferrebee, M.D., The Mary Imogene Bassett Hospital, Cooperstown, N. Y.†Radiation that knocks electrons off molecules and produces biochemical change.‡Cells taken from members of the same species. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byKidney Complications of Hematopoietic Stem Cell TransplantationComparative analysis of BU and CY versus CY and TBI in full intensity unrelated marrow donor transplantation for AML, CML and myelodysplasiaChronic graft-versus-host disease and late effects after hematopoietic stem cell transplantationTransplantations-Immunität und Transplantations-Toleranz in bezug auf normale Gewebe und OrganeFactors Affecting Human Antibody ResponseRadiation ChimerasIRRADIATION AND MARROW TRANSPLANTATIONLeukemia: Some Present-Day ProblemsKnochenmarktransplantationExperimental treatment of acute whole-body radiation injury in mammalsStudies of Intravenous Fe59 GlobulinTechnics of Human-Bone-Marrow Procurement by Aspiration from Living DonorsLeukemia and Lymphoma in Children 1 November 1958Volume 49, Issue 5Page: 987-1003KeywordsBone marrowCellsHemorrhageHomograftsIonizing radiationSepsis ePublished: 1 December 2008 Issue Published: 1 November 1958 PDF downloadLoading ...