UROPEPSIN EXCRETION IN THE DIFFERENTIAL DIAGNOSIS OF GASTROINTESTINAL BLEEDING
Authors: A J CUMMINS
Journal: Annals of Internal Medicine (1960)

Article1 June 1960UROPEPSIN EXCRETION IN THE DIFFERENTIAL DIAGNOSIS OF GASTROINTESTINAL BLEEDINGALVIN J. CUMMINS, M.D., F.A.C.P.ALVIN J. CUMMINS, M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-52-6-1213 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptINTRODUCTIONSeveral proteolytic enzymes are known to exist in the blood and urine, and one of the urinary enzymes—uropepsin—has received much attention and study since Bucher's review of the subject in 1947.1Available evidence indicates that the chief cells of the gastric glands secrete pepsinogen both into the gastric lumen and into the blood in a ratio of about 99:1.2In the stomach the enzyme precursor is activated to pepsin by hydrochloric acid, while from the blood stream it is excreted in the urine, where it can be assayed at an acid pH as uropepsin. Urinary excretion of uropepsin has...Bibliography1. Bucher GR: Uropepsin: review of literature and report of some experimental findings, Gastroenterology 8: 627, 1947. MedlineGoogle Scholar2. JanowitzHollander HDF: Relation of uropepsinogen excretion to gastric pepsin secretion in man, J. Appl. Physiol. 4: 53, 1951. CrossrefMedlineGoogle Scholar3. HoarBrowning CSJR: Plasma pepsinogen in peptic-ulcer disease and other gastric disorders, New England J. Med. 255: 153, 1956. CrossrefMedlineGoogle Scholar4. JanowitzLevyHollander HDMHF: The diagnostic significance of urinary pepsinogen excretion in diseases of the upper gastrointestinal tract, Am. J. M. Sc. 220: 679, 1950. CrossrefMedlineGoogle Scholar5. GrayRamseyReifenstein SJCGRW: Clinical use of the urinary uropepsin determination in medicine and surgery, New England J. Med. 251: 835, 1954. CrossrefMedlineGoogle Scholar6. CorazzaMyerson LJRM: The influence of various clinical disorders and drugs on excretion of uropepsin, J. A. M. 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Author, Article, and Disclosure InformationAffiliations: *Received for publication November 16, 1959.Presented at the Tennessee-Kentucky Regional Meeting of The American College of Physicians, Nashville, Tennessee, October 31, 1959.From the Gastrointestinal Laboratory, Department of Medicine, University of Tennessee College of Medicine, and the John Gaston Hospital, Memphis.†This work was supported by a grant from the U. S. Public Health Service (N.I.H. RG-4829).Requests for reprints should be addressed to Alvin J. Cummins, M.D., Associate Professor of Medicine, The University of Tennessee, 858 Madison Avenue, Memphis 3, Tennessee. 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