PARENTERAL B_12-FOLIC ACID THERAPY IN PERNICIOUS ANEMIA
Authors: E H SANNEMAN, M BEARD
Journal: Annals of Internal Medicine (1952)

Article1 October 1952PARENTERAL B12-FOLIC ACID THERAPY IN PERNICIOUS ANEMIAEVERETT H. SANNEMAN JR., M.D., MARION F. BEARD, A.B., M.D., F.A.C.P.EVERETT H. SANNEMAN JR., M.D.Search for more papers by this author, MARION F. BEARD, A.B., M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-37-4-755 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptINTRODUCTIONThe simultaneous discovery of vitamin B12by Rickes and his co-workers1and by Smith2was soon followed by numerous clinical reports3, 4, 5, 6of its efficacy in treating pernicious anemia in relapse. Many reports, particularly those of Ungley3and Meacham et al.,9suggested that it was equally effective as a maintenance therapy. Our group,7however, has reported that in certain instances vitamin B12alone is not a complete maintenance therapy, and the data suggested that some additional factor was necessary. Meyer10has reported on the effectiveness of a combination of folic acid and vitamin B12orally. Bethell11and...Bibliography1. RickesBrinkKoniuszyWoodFolkers ELNCFRTRK: Crystalline vitamin B12 , Science 107: 396-397 (Apr.) 1948. CrossrefMedlineGoogle Scholar2. SmithParker ELLF: Purification of anti-pernicious anemia factor from liver, Nature, London 161: 638 (Apr. 24) 1948. CrossrefMedlineGoogle Scholar3. Ungley CC: Vitamin B12 in pernicious anemia: parenteral administration, Brit. M. J. 2: 1370 (Dec. 17) 1949. CrossrefMedlineGoogle Scholar4. SpiesSuarezLopezMilanesStoneTocaAramburuKartus TDRMGGFRERLTS: Tentative appraisal of vitamin B12 as a therapeutic agent, J. A. M. A. 139: 521-525 (Feb.) 1949. CrossrefMedlineGoogle Scholar5. HallCampbell BEDC: Vitamin B12 therapy in pernicious anemia. Part I, Effect on hematopoietic system, preliminary report, Proc. Staff Meet., Mayo Clin. 23: 584-590, Part II, Effect of the general clinical and neurologic manifestations, Proc. Staff Meet., Mayo Clinic 23: 591-595, 1948. MedlineGoogle Scholar6. JonesDarbyTotter EWJJR: Pernicious anemia and related anemias treated with vitamin B12 , Blood 4: 827-843, 1949. CrossrefMedlineGoogle Scholar7. BeardMcIlvaineNatarro MFSKM: Vitamin B12 in pernicious anemia in remission, South. M. J. 43: 678-685 (Aug.) 1950. CrossrefGoogle Scholar8. UngleyThompson CCRB: Vitamin B12 and folic acid in megaloblastic anemias of pregnancy and the puerperium, Brit. M. J. 1: 4659 (Apr. 22) 1950. CrossrefGoogle Scholar9. MeachamVignesHeinleWeisbergerEpstein GPTRWASM: Vitamin B12 concentrate in the maintenance of pernicious anemia, J. Lab. and Clin. Med. 35: 713-720 (May) 1950. MedlineGoogle Scholar10. MeyerSawitskyRitzKrim LMANDM: Oral treatment of pernicious anemia with subminimal doses of folic acid and vitamin B12 , Am. J. Clin. Path. 20: 454-457 (May) 1950. CrossrefMedlineGoogle Scholar11. BethellMeyersNeligh FHMCRB: Vitamin B12 in pernicious anemia and puerperal macrocytic anemia, J. Lab. and Clin. Med. 33: 1477-1478 (Nov.) 1948. MedlineGoogle Scholar12. BeardMcIlvaine MFSK: Vitamin B12 as a hemotherapeutic agent in pernicious anemia, Proceedings of the Third International Society of Hematology, 1951, Grune & Stratton, New York, p. 34. Google Scholar13. VilterHorriganMuellerJarroldVilterHawkinsSeaman RWDJFTCFVA: Studies on the relationships of vitamin B12, folic acid, thymine, uracil, and methyl group donors in persons with pernicious anemia and related megaloblastic anemias, Blood 5: 695-717 (Aug.) 1950. CrossrefMedlineGoogle Scholar14. NicholDietrichElvehjemHart CALSCAEB: Observations on folic acid deficiency in the chick in presence of vitamin B12 , J. Nutrition 39: 287-298 (Nov.) 1949. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Louisville, Kentucky*Read before the Kentucky Chapter of The American College of Physicians, Louisville, Kentucky, October 27, 1951. Received for publication April 12, 1952.This study was made possible by a grant from the Squibb Institute for Medical Research, New Brunswick, New Jersey.†Rubrafolin, furnished by E. R. Squibb & Sons, New York. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byVitamine und Vitaminkrankheiten 1 October 1952Volume 37, Issue 4Page: 755-760KeywordsFolic acidPernicious anemia ePublished: 1 December 2008 Issue Published: 1 October 1952 PDF downloadLoading ...