tbuckley/cabot-search huggingface dataset:
Fortnightly review: The role of nuclear medicine in clinical investigation
Authors: E M Prvulovich, J B Bomanji
Journal: BMJ (1998)

Nuclear medicine uses radioactive isotopes for the diagnosis and treatment of patients. Whereas radiology provides data mostly on structure, nuclear medicine provides complementary information about function. Limited undergraduate teaching, together with regional differences in the provision of nuclear medicine services, means that many clinicians know little about how radionuclide techniques can help in the management of patients. Consequently, patients who would benefit from such a procedure are not referred. This review highlights how nuclear medicine techniques can be used in the investigation of patients presenting with such common conditions as ischaemic chest pain, malignancy, and suspected pulmonary embolism. Many promising new tracers are being developed, particularly for the investigation of patients with malignancy and suspected infection, and readers will be directed elsewhere for information.



Fig 1 
201Tl myocardial perfusion images in a patient with exertional chest pain. Reversible ischaemia of the anterior, inferior, and lateral walls suggests a high probability of future cardiac events



#### Summary points

The published articles reviewed here were chosen primarily for the clarity and simplicity with which they describe the role of nuclear medicine techniques in specific fields. Six short texts commissioned by the British Nuclear Medicine Society provide detailed reviews of the …
Photocoagulation Treatment of Proliferative Diabetic Retinopathy: The Second Report of Diabetic Retinopathy Study Findings
Authors: Arnall Patz, Stuart Fine, Daniel Finkelstein, Thaddeus Prout, Lloyd Aiello, Robert Bradley, Jose C. Briones, Frank Myers, George Bresnick, Guillermo de Venecia, Thomas S. Stevens, Ingolf H.L. Wallow, Suresh R. Chandra, Edward Norton, George Blankenship, John Harris, William Knobloch, Frederick Goetz, Robert C. Ramsay, J. Wallace McMeel, Donald Martin, Morton Goldberg, Felipe Huamonte, Gholam Peyman, Bradley Straatsma, Stanley Kopelow, W.A.J. van Heuven, Aaron Kassoff, Stephen Feman, Robert Watzke, John Mensher, William Tasman, William Annesley, Brian Leonard, Christopher Canny, Leonard Joffe, Thomas Pheasant, F. Tempel Riekhof, Mary Dahl, William Bohart, Dana Clarke, Jose Berrocal, Antonio Ramos-Umpierre, Guillermo Velazquez, Raymond Margherio, Delbert Nachazel, Edward McLean, Steven Guzak, Genell Knatterud, Christian Klimt, Argye Hillis, Diane Makuc, Matthew Davis, Alasdair MacCormick, Yvonne Magli, Paul Segal
Journal: Ophthalmology (1978)
Abstract 12999: Different Response to Exercise Testing between Andersen-Tawil Syndrome and Catecholaminergic Polymorphic Ventricular Tachycardia
Authors: Yuko Yamada, Tomoko Sakaguchi, Ikutaro Nakajima, Koji Miyamoto, Hideo Okamura, Takashi Noda, Kazuhiro Satomi, Takeshi Aiba, Toshihisa Anzai, Masaharu Ishihara, Satoshi Yasuda, Hisao Ogawa, Shiro Kamakura, Minoru Horie, Wataru Shimizu
Journal: Circulation (2012)

Introduction:Andersen-Tawil Syndrome (ATS) and catecholaminergic polymorphic ventricular tachycardia (CPVT) are both inherited arrhythmic disorders characterized by bigeminy of premature ventricula...
Abstract 110: The Relationship Between Chest Compression Depth and Complete Chest Recoil Varies by Rescuer Type and CPR Technique
Authors: Tom P Aufderheide, Demetris Yannopoulos, John P Klein, Ronald G Pirrallo, Walter Bialkowski, Joseph Brandt, Terry A Provo, Keith G Lurie
Journal: Circulation (2010)

Introduction: Chest compression depth and complete chest recoil (CCR) are essential and hemodynamically significant components of CPR. Hypothesis: We tested the hypothesis that there is a relations...
Woman From Brittany
Authors: M. Therese Southgate
Journal: JAMA (2002)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
VARIABILITY OF SIGNS IN MULTIPLE SCLEROSIS
Authors: I C SHERMAN
Journal: Annals of Internal Medicine (1951)

Article1 December 1951VARIABILITY OF SIGNS IN MULTIPLE SCLEROSISIRVING C. SHERMAN, M.D.IRVING C. SHERMAN, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-35-6-1329 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptIn a recent study of the effect of tetraethylammonium chloride on the course of multiple sclerosis, there became available for analysis a group of patients who were examined on repeated occasions. These patients frequently showed a variability in objective signs which at first was thought due to the treatment. However, careful study, as reported elsewhere,1 revealed that actually the treatment had no effect on the course of the disease.If a drug is efficacious in the treatment of multiple sclerosis, then the majority of the pathologic signs should show amelioration. Actually it was found that, although a certain number of...Bibliography1. ArkinShermanWeinberg HICS: Tetraethylammonium chloride in the treatment of multiple sclerosis, Arch. Neurol. and Psychiat. 64: 536-545, 1950. CrossrefGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Chicago, Illinois*Read before the Chicago Neurological Society, November 14, 1950. Received for publication December 20, 1950.From the Division of Neuropsychiatry, Michael Reese Hospital, Chicago, and the Department of Nervous and Mental Diseases, Northwestern University Medical School, Chicago, Illinois. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 December 1951Volume 35, Issue 6Page: 1329-1335KeywordsChloridesDrugsMultiple sclerosis ePublished: 1 December 2008 Issue Published: 1 December 1951 PDF downloadLoading ...
Randomised trial of a perindopril-based blood-pressure-lowering regimen among 6105 individuals with previous stroke or transient ischaemic attack
Authors: S. MacMahon, B. Neal, C. Tzourio, A. Rodgers, M. Woodward, J. Cutler, C. Anderson, J. Chalmers, T. Ohkubo, M. G. Bouser, S. Davis, G. Donnan, L. Hansson, S. Harrap, K. R. Lees, L. Liu, G. Mancia, T. Omae, J. Reid, R. Sega, A. Terent, C. Warlow, N. Anderson, C. Bladin, B. Chambers, G. Gordon, N. Sharpe, R. Collins, P. Sandercock, J. Simes, P. Sleight, A. Brnabic, S. Colman, L. Francis, A. Lee, L. Gong, M. G. Bousser, T. Yamaguchi, F. William, Q. Deng, D. X. Hu, W. Wang, A. L. Wu, L. Y. Ma, Z. Y. Tao, V. Biousse, K. Berthet, L. Ben Slamia, C. Le Denmat, S. Crespi, G. Foglia, C. Fujimoto, S. Matsumura, K. Marttala, M. Pettersson, M. Safwenberg, J. Fenton, Y. McIlvenna, R. Currie, H. Bartram, J. Briad, A. Clague, Y. Cleverly, M. Cosson, A. Culpan, D. Douglas, S. Flett, B. Gray, T. Holloway, A. Milne, R. Prasad, Y. Ratnasabapathy, A. Santos, M. Wills, T. Agnew, N. Chapman, N. Lewis, B. Mullane
Journal: The Lancet (2001)
Exhaled breath temperature in NSCLC: Could be a new non invasive marker?
Authors: Giovanna Elisiana Carpagnano, Giulia Scioscia, Donato Lacedonia, Antonio Spanevello, Domenico Martinelli, Valerio Saliani, Cinzia Ruggieri, Maria Pia Foschino-Barbaro
Journal: European Respiratory Journal (2014)

Background and aim:  The exhaled breath temperature (EBT) has been proven to be the expression of airways inflammation as well as of the increased vascularity. Although both these conditions characterize lung cancer pathogenesis, this is the first study where the exhaled breath temperature has been analysed in patients affected by non-small cell lung cancer. The aim of this study was to verify whether and how the lung cancer being examined influences the exhaled breath temperature for possible future clinical implicatio ns.    Material and Methods:  82 consecutive subjects with a radiological suspicion of lung cancer were enrolled and underwent standard diagnostic and staging procedures for cancer. EBT was measured in all the subjects at the enrollement with the X-Halo device.   Results:  40 patients resulted as affected by lung cancer while 42 as false positive (controls). We found a higher exhaled breath temperature in NSCLC patients compared to healthy subjects. The EBT was correlated with number of packs/years and associated with the stage of lung cancer. We identified a cut-off value for the EBT that is able to screen patients with lung cancer with a high sensitivity and specificity.   Conclusions:  Our results suggest that lung cancer causes an increase of the exhaled breath temperature which, whether confirmed and validated, could become a new non-invasive clinical tool in the screening and monitoring of this disease.   Key words:  exhaled breath temperature, non invasive methods, non small cell lung cancer, airways inflammation, neoangiogenesis.
The Verdict of the People
Authors: M. Therese Southgate
Journal: JAMA (1998)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Autism and the Alphabet
Authors: Tracy Hampton
Journal: JAMA (2005)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Basal Blood Pressure in the Normal
Authors: Fred N. Miller, Wilmoth Osborne, Ronald C. Romig
Journal: Annals of Internal Medicine (1927)

Article1 October 1927Basal Blood Pressure in the NormalFRED N. MILLER, M.D., WILMOTH OSBORNE, M.D., RONALD C. ROMIG, M.D.FRED N. MILLER, M.D.Search for more papers by this author, WILMOTH OSBORNE, M.D.Search for more papers by this author, RONALD C. ROMIG, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-1-4-231 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptProbably one of the greatest advances in internal medicine during the last half century has been the increasingly more common recognition of the fact that the important consideration in evaluating the condition of the heart is its capacity for doing work. Today the detection of murmurs is only a small part—and often an insignificant part—of the problem of estimating the health of the heart.Similarly the mere determination of a blood pressure of a given number of millimeters falls far short of giving us a definite prognosis of any case. Ehrstrom (1) in analyzing a group of 20 who were...References(1) EHRSTROM R: Prognosis of hypertension. Klin. Wchnschr. 5, 469-470, March 12, 1926; Ab. J. A. M. A. 86: 386, January 30, 1926. Google Scholar(2) SLADENJOHNSTON FJRL: The significance of basal blood pressure readings. Ann. of Clin. Med. 5: 593, January, 1927. Google Scholar(3) MACWILLIAM JA; Blood pressure in man under normal and pathological conditions. Phys. Rev. 5: 303, July, 1925. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Eugene, Oregon*From the Health Service, Dept. of Physical Education, University of Oregon, Eugene, Oregon. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byHow should BP be measured in the office? 1 October 1927Volume 1, Issue 4Page: 231-234KeywordsBlood pressureFallsHeartMedical services Issue Published: 1 October 1927 PDF downloadLoading ...
Pathophysiology of Renal Disease.
Authors: Burton David Rose
Journal: Annals of Internal Medicine (1982)

Clinical Assessment of Renal Function. Diagnostic Approach to the Patient with Renal Disease. Acute Renal Failure: Prerenal Disease Versus Acute Tubular Necrosis. Mechanisms of Progression of Renal Disease. Pathogenesis, Clinical Manifestations, and Diagnosis of Glomerular Disease. Nephrotic Syndrome and Glomerulonephritis. Vascular Diseases of the Kidney. Tubulointerstitial Diseases. Urinary Tract Obstruction. Pathogenesis of Essential Hypertension. Course and Management of Essential Hypertension. Renovascular Hypertension. Use of Drugs in the Patient with Renal Insufficiency.
Public-Access Defibrillation and Survival after Out-of-Hospital Cardiac Arrest
Authors: A P Hallstrom, J P Ornato, M Weisfeldt, A Travers, J Christenson, M A McBurnie, R Zalenski, L B Becker, E B Schron, M Proschan
Journal: New England Journal of Medicine (2004)

The rate of survival after out-of-hospital cardiac arrest is low. It is not known whether this rate will increase if laypersons are trained to attempt defibrillation with the use of automated external defibrillators (AEDs).We conducted a prospective, community-based, multicenter clinical trial in which we randomly assigned community units (e.g., shopping malls and apartment complexes) to a structured and monitored emergency-response system involving lay volunteers trained in cardiopulmonary resuscitation (CPR) alone or in CPR and the use of AEDs. The primary outcome was survival to hospital discharge.More than 19,000 volunteer responders from 993 community units in 24 North American regions participated. The two study groups had similar unit and volunteer characteristics. Patients with treated out-of-hospital cardiac arrest in the two groups were similar in age (mean, 69.8 years), proportion of men (67 percent), rate of cardiac arrest in a public location (70 percent), and rate of witnessed cardiac arrest (72 percent). No inappropriate shocks were delivered. There were more survivors to hospital discharge in the units assigned to have volunteers trained in CPR plus the use of AEDs (30 survivors among 128 arrests) than there were in the units assigned to have volunteers trained only in CPR (15 among 107; P=0.03; relative risk, 2.0; 95 percent confidence interval, 1.07 to 3.77); there were only 2 survivors in residential complexes. Functional status at hospital discharge did not differ between the two groups.Training and equipping volunteers to attempt early defibrillation within a structured response system can increase the number of survivors to hospital discharge after out-of-hospital cardiac arrest in public locations. Trained laypersons can use AEDs safely and effectively.
Anti-Slavery Picnic at Weymouth Landing, Massachusetts
Authors: M. Therese Southgate
Journal: JAMA (1999)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Treatment of the Primary Tumor in Metastatic Prostate Cancer: Current Concepts and Future Perspectives
Authors: Christopher E. Bayne, Stephen B. Williams, Matthew R. Cooperberg, Martin E. Gleave, Markus Graefen, Francesco Montorsi, Giacomo Novara, Marc C. Smaldone, Prasanna Sooriakumaran, Peter N. Wiklund, Brian F. Chapin
Journal: European Urology (2015)
Abstract 17458: Which is Superior for the Diagnosis of Underlying Etiology in Heart Failure, Cardiac Magnetic Resonance or Endomyocardial Biopsy?
Authors: Akemi Yoshida, Hatsue Ishibashi-Ueda, Naoaki Yamada, Masanori Asakura, Masafumi Kitakaze
Journal: Circulation (2010)

Background: Cardiac magnetic resonance (CMR) is a noninvasive imaging technique that is rapidly emerging and increasingly used for the patients with heart failure, however, diagnostic performance o...
The role of cytokine gene polymorphisms in acute rejection after liver transplantation
Authors: C. Hong, E. E. Powell, G. A. Balderson, A. D. Clouston, D. M. Purdie, N. Pandeya, C. J. Edwards-Smith, K. A. Stuart, D. H. Crawford, J. Fawcett, S. V. Lynch, J. R. Jonsson
Journal: Hepatology (2000)
Salvage chemotherapy and autologous stem cell transplantation for transformed indolent lymphoma: a subset analysis of NCIC CTG LY12
Authors: John Kuruvilla, David A. MacDonald, C. Tom Kouroukis, Matthew Cheung, Harold J. Olney, A. Robert Turner, Peter Anglin, Matthew Seftel, Walid Sabry Ismail, Stefano Luminari, Stephen Couban, Tara Baetz, Ralph M. Meyer, Annette E. Hay, Lois Shepherd, Marina S. Djurfeldt, Sameer Alamoudi, Bingshu E. Chen, Michael Crump
Journal: Blood (2015)
Abstract 4187: Splicing factors <i>ESRP1/ESRP2</i> as regulators of endocrine resistance in breast cancer
Authors: Yesim Gokmen-Polar, Yaseswini Nellamraju, Xiaoping Gu, Sarath C. Janga, Sunil S. Badve
Journal: Cancer Research (2014)

Abstract Deregulation of alternative splicing (AS) has been implicated in the development of drug resistance, tumor progression and metastasis. RNA-binding proteins (RBPs) as controllers of AS may act as master regulators of cellular behavior. Among the RBPs, we previously have shown that the expression of epithelial splicing regulatory proteins 1 and 2 (ESRP1 &amp; ESRP2) have significantly elevated in cases with high Oncotype DX scores and in ERα-positive cells with acquired tamoxifen resistance (MCF-7/ LCC2) (SABCS 2013). This study seeks to identify genes and their splice variants that are regulated by ESRP1 &amp; ESRP2 and could cause development of endocrine resistance. To identify alternatively spliced genes by ESRP1 &amp; ESRP2 in endocrine resistance, we have performed a four step bioinformatics approach as follows: 1) Motif analysis to identify genes targeted by ESRP1 &amp; ESRP2, 2) Comparison of differentially expressed genes in tamoxifen treated samples (GSE17700 and GSE17705) with genes targeted by ESRP1 &amp; ESRP2 identified above, 3) Protein-protein interaction from BIOGRID and 4) survival data using publically available datasets (KM Plotter). Motif analysis identified 15,450 genes targeted both by ESRP1 (P&amp;lt;3.39e-05) and ESRP2 (P&amp;lt; 5.53e-05). 2212 of these genes were differentially expressed in tamoxifen treated cases. This set of genes was further categorized based on the ESRP1 &amp; ESRP2 enhancer/ suppressor motifs ratio resulting in 1260 genes. Further collective analysis of survival data from KM plotter (P&amp;lt;0.001) and number of protein-protein interactions (&amp;gt;50) narrowed down 79 candidate genes that are associated with tamoxifen resistance. Some of the genes (AURKA, ERRB3, ESR2, EGFR, and MDM2) have been previously implicated in the de novo or acquired resistance to tamoxifen. Validation of splicing variants of these genes in human tumors is ongoing. Elevated expression of ESRP1 &amp; ESRP2 and its target genes play an important role in the development of tamoxifen resistance and recurrence of ER+ breast cancer. ESRP1 &amp; ESRP2 by affecting splicing have the potential to induce tamoxifen resistance via multiple genes and pathways. Targeting ESRP1 &amp; ESRP2 may offer novel avenues for combating endocrine-resistance in breast cancer. Citation Format: Yesim Gokmen-Polar, Yaseswini Nellamraju, Xiaoping Gu, Sarath C. Janga, Sunil S. Badve. Splicing factors ESRP1/ESRP2 as regulators of endocrine resistance in breast cancer. [abstract]. In: Proceedings of the 105th Annual Meeting of the American Association for Cancer Research; 2014 Apr 5-9; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2014;74(19 Suppl):Abstract nr 4187. doi:10.1158/1538-7445.AM2014-4187