Regression of Gastric Lymphoma with Therapy for Helicobacter pylori Infection
Authors: John F. Seymour
Journal: Annals of Internal Medicine (1997)

Letters1 August 1997Regression of Gastric Lymphoma with Therapy for Helicobacter pylori InfectionJohn F. Seymour, MB, BS, FRACP, Robert P. Anderson, MB, ChB, PhD, FRACP, and Prithi S. Bhathal, MB, BS, PhD, FRACPJohn F. Seymour, MB, BS, FRACPThe Royal Melbourne Hospital; Parkville 3050, Australia, Robert P. Anderson, MB, ChB, PhD, FRACPThe Royal Melbourne Hospital; Parkville 3050, Australia, and Prithi S. Bhathal, MB, BS, PhD, FRACPThe Royal Melbourne Hospital; Parkville 3050, AustraliaAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-127-3-199708010-00026 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:The normal stomach has no resident lymphoid tissue, but Helicobacter pylori infection elicits lymphocytic infiltration [1]. Infrequently, a clone of mature B lymphocytes then arises, the proliferation of which depends on factors produced by benign T lymphocytes in the presence of H. pylori[2]. These factors include tumor necrosis factor-α, interleukin-6, interleukin-1β, and interleukin-10 [3]. Eradication of H. pylori usually induces durable regression of these low-grade mucosa-associated lymphoid tissue (MALT) lymphomas [4], suggesting that although they are unequivocally clonal, they remain dependent on T-cell-derived stimulation. Although often thought to arise from low-grade MALT lymphoma through clonal evolution [5], ...References1. Stolte M, Eidt S. Lymphoid follicles in the antral mucosa: immune response to Campylobacter pylori. J Clin Pathol. 1989; 42:1269-71. Google Scholar2. Hussell T, Isaacson P, Crabtree JE, Spencer J. The response of cells from low-grade B-cell gastric lymphomas of mucosa-associated lymphoid tissue to Helicobacter pylori. Lancet. 1993; 342:571-4. Google Scholar3. Blasser MJ, Parsonnet J. Parasitism by the "slow" bacterium Helicobacter pylori leads to altered gastric homeostasis and neoplasia. J. Clin Invest. 1994; 94:4-8. Google Scholar4. Roggero E, Zucca E, Pinotti G, Pascarella A, Capella C, Savio A, et al. Eradication of Helicobacter pylori infection in primary low-grade gastric lymphoma of mucosa-associated lymphoid tissue. Ann Intern Med. 1995; 122:767-9. Google Scholar5. Chan JK, Ng CS, Isaacson PG. Relationship between high-grade lymphoma and low-grade B-cell mucosa-associated lymphoid tissue lymphoma (MALToma) of the stomach. Am J Pathol. 1990; 136:1153 64. Google Scholar Author, Article, and Disclosure InformationAuthors: John F. Seymour, MB, BS, FRACP; Robert P. Anderson, MB, ChB, PhD, FRACP; Prithi S. Bhathal, MB, BS, PhD, FRACPAffiliations: The Royal Melbourne Hospital; Parkville 3050, Australia PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byEfficacy of Helicobater pylori eradication in patients with diffuse large B‐cell lymphoma of the stomach: A systematic reviewIncidence and Mortality Trends and Risk Prediction Nomogram for Extranodal Diffuse Large B-Cell Lymphoma: An Analysis of the Surveillance, Epidemiology, and End Results DatabasePREDICTIVE VALUE OF ENDOSCOPY AND ENDOSCOPIC ULTRASONOGRAPHY FOR REGRESSION OF GASTRIC DIFFUSE LARGE B-CELL LYMPHOMAS AFTER HELICOBACTER PYLORI ERADICATIONHigh grade B-cell gastric lymphoma with complete pathologic remission after eradication of helicobacter pylori infection: Report of a case and review of the literatureThe value of EUS in predicting the response of gastric mucosa–associated lymphoid tissue lymphoma to Helicobacter pylori eradicationLong-Term Results of Anti– Helicobacter pylori Therapy in Early-Stage Gastric High-Grade Transformed MALT LymphomaEpstein-Barr virus-negative gastric large B-cell lymphoma after kidney transplantationTreatment of extranodal lymphomasProspective Study of Helicobacter pylori Eradication Therapy in Stage I E High-Grade Mucosa-Associated Lymphoid Tissue Lymphoma of the StomachRegression of primary gastric diffuse large B-cell lymphoma after eradication of Helicobacter pyloriComplete Remission of Primary High-Grade B-Cell Gastric Lymphoma After Cure of Helicobacter pylori InfectionNon-surgical treatment of histologically aggressive gastric non-Hodgkin's lymphoma: a review articleThe gastric marginal zone B-cell lymphoma of MALT typeThe gastric marginal zone B-cell lymphoma of MALT typeHelicobacter pylori. One bacterium and a broad spectrum of human disease! An overviewRe: Cure of Helicobacter pylori Infection and Duration of Remission in Low-Grade Gastric Mucosa-Associated Lymphoid Tissue LymphomaResponseB‐CELL LYMPHOMA OF MALT TYPE: A REVIEW WITH SPECIAL EMPHASIS ON DIAGNOSTIC AND MANAGEMENT PROBLEMS OF LOW‐GRADE GASTRIC TUMOURS 1 August 1997Volume 127, Issue 3Page: 247KeywordsBiopsyGastritisHelicobacter pylori infectionLymphocytesLymphoid tissueLymphomaMALT lymphomaStomachUlcersWeight loss ePublished: 15 August 2000 Issue Published: 1 August 1997 Copyright & PermissionsCopyright © 1997 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...