HEPATIC DYSFUNCTION DUE TO CHLORPROMAZINE HYPERSENSITIVITY
Authors: L WAITZKIN
Journal: Annals of Internal Medicine (1958)

Article1 September 1958HEPATIC DYSFUNCTION DUE TO CHLORPROMAZINE HYPERSENSITIVITYLEO WAITZKIN, M.D.LEO WAITZKIN, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-49-3-607 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe complete pathogenesis of jaundice due to chlorpromazine is obscure, but a number of facts have become known.Approximately 1% of people treated with chlorpromazine for two or more weeks have developed clinical jaundice.1Its appearance has first been noted 10 to 31 days after the initiation of drug therapy,2, 3, 4and as long as 18 days after withdrawal of the drug.2, 5, 6Its incidence and severity have not been influenced by age, sex, size of daily dose or duration of drug therapy before icterus. It has occurred after as little as 50 to 75 mg. taken for...Bibliography1. 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Lowell FC: Allergic reactions to sulfonamide and antibiotic drugs, Ann. Int. Med. 43: 333-344, 1955. LinkGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Brockton, Massachusetts*Received for publication December 13, 1957.From the Medical Service, Veterans Administration Hospital, Brockton, Massachusetts.Requests for reprints should be addressed to Leo Waitzkin, M.D., Chief, Medical Service, Veterans Administration Hospital, Brockton, Massachusetts. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byThe Class is Greener on the Other Side: How Private Donations to Public Schools Play into Fair FundingExaggerated cholestasis and hepatic fibrosis following simultaneous administration of chlorpromazine and sodium valproateSurface activity, cellular uptake and cytotoxicity of tricyclic psychoactive drugs in vitroA clinical pharmacologist's view of drug hepatotoxicityThe effect of intramuscular chlorpromazine on the serum transaminases (SGOT and SGPT)Chlorpromazine in chronic schizophrenic women: Its effect on thyroid and liver function in relation to serum cholesterol concentrationThe Importance of the Measurement of Enzyme Activity in MedicineIntrahepatic CholestasisJAUNDICE AND ITS RELATION TO THERAPEUTIC AGENTSMECHANISMS OF INTRAHEPATIC CHOLESTASIS IN DRUG-INDUCED HEPATIC INJURY*Phenothiazine und Azaphenothiazine als HeilmittelPROBABLE HEPATIC ALLERGY TO CHLORPROMAZINE AND DELIBERATE DESENSITIZATION*LEO WAITZKIN, M.D.Agranulocytosis and Jaundice during Therapy with Meprobamate and PromazineZur Megaphenwirkung auf Leber und Nebennierenrinde der RattePROGRESSIVE CHLORPROMAZINE JAUNDICE DURING PREGNANCYIntrahepatic Obstructive JaundiceJaundice Secondary to Promazine, and an Analysis of Possible Cross Sensitivities Between Phenothiazine DerivativesThe Early Recognition of Drug-Induced Liver DiseaseDRUG-INDUCED HEPATIC INJURY*HANS POPPER, M.D., F.A.C.P., FENTON SCHAFFNER, M.D., F.A.C.P. 1 September 1958Volume 49, Issue 3Page: 607-619KeywordsAminotransferasesBileChlorpromazineDrug therapyExcretionHypersensitivityMedical servicesPathogenesisPhosphatases ePublished: 1 December 2008 Issue Published: 1 September 1958 PDF downloadLoading ...