SEVERE INJURY TO KIDNEYS AND BRAIN FOLLOWING SULFATHIAZOLE ADMINISTRATION: HIGH SERUM SODIUM AND CHLORIDE LEVELS AND PERSISTENT CEREBRAL DAMAGE
Authors: John A. Luetscher, Sam S. Blackman
Journal: Annals of Internal Medicine (1943)

Article1 May 1943SEVERE INJURY TO KIDNEYS AND BRAIN FOLLOWING SULFATHIAZOLE ADMINISTRATION: HIGH SERUM SODIUM AND CHLORIDE LEVELS AND PERSISTENT CEREBRAL DAMAGEJOHN A. LUETSCHER JR., SAM S. BLACKMAN JR.JOHN A. LUETSCHER JR., SAM S. BLACKMAN JR.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-18-5-741 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptFive patients with a history of recent sulfonamide medication have developed an unusual type of renal insufficiency, as well as evidence of injury to the brain. The patients presented a temporary, severe disturbance of serum sodium and chloride concentration, which was responsible, at least in part, for the death of two patients. In all cases there were signs of injury to the central nervous system, which persisted in two patients despite return of the blood chemistry to normal.Case 1. 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