tbuckley/cabot-search huggingface dataset:
SOME RESULTS OF GERMAN GAS POISONING
Authors: W. Broadbent
Journal: BMJ (1915)

Literature.I have not been able to finid in the literature any refer- enices to the immediate plhysiological action of clhlorine.''hlie ilost exact worlk on the effects of respiring mixtures of clhlorine and air is that of Lelhmann,2 Wllo plaCed afll-lais d(IuViug onie to six lhours in afftiosplheres contain- iiro fiuii I-part p-e 1,00,000 to 1 part erl1,000.He fouind thlat prolonged exp6ostie fo 1 pai't in 100,000 is suffidient to produce putliiuonary hlaemorlrhage and oedema wllilh lie regards as inflamunatory-whilst exposure to 1 part in 10,000 catnses in 'additioh a lbbrinous (" croupouis") exudat.oun in all ttie aiL passages, eVeh tlle flnest, and appea'rs ultiiimately to piodu'ce asp)lyxiatio,n.Numerous expert- mlental pathioiogfsts, 'inchling; W5eleh,83S."Miaybi,4 Salhli,5 indULt_Wit6 hlave 'n46ckavobir"ed to elti6idate tlh6 conditio'ns of 'pr6ductio'l of pulmonirly o6dema'.'T'h6se conditiidns liave also lately been studkid in' tlle I'siirviving " lung in Ma<,iius's laobdratory at"Utredlht by Mo'drakowski.7 IA these las`t-mleiftiioned paper's'tlhe literature of tLe subject is given, btht most oft thle Vb-rk refeired to hlas but little bearing lipon the oedemna puodu6cd by clhlorine.-Binz 8 fotuid in, tlhe frog that exposture to-clboiine gas hlas ,no influence on the lheart (as agaiuitt Falk', noi; on muscle and nerve, nlOLOr l ile e spinal cord, buit believes that it is-carried to tle brain, in' wllich, h&6 states, it can be detected by thle siunlle I liamie not noticed any snell of chlorine 2?ost inortehi7 in the animals I lhave dealt witlh.
Points from letters: Medical Science--Master or servant?
Authors: M. S. Rose
Journal: BMJ (1967)

A. M. Poornan (19 August, p. 500) and G. Murtaza (28 October, p. 239) about the rejection of their claims for seniority allow- ance by the Ministry of Health.The ruling of the Ministry is incompatible with the spirit and principle with which the Review Body introduced this payment.In para.159 of the Report' it states that this payment " will recognize the development of experience in the general practitioner, and will provide him with the prospect of maintaining the level of his remuneration at a time when he may wish with advancing age . . .
Function and public awareness of sustainable development and population health projects in Montreal, Canada: a logic model and survey of the Quartiers 21 Program
Authors: Lise Gauvin, Celine Gosselin, Sophie Paquin, Anne S Dubé, Sophie Goudreau, Marie-Hélène Poirier, Annie Côté-Bernatchez, Michel Fournier, Nicoleta Cutumisu, Danielle Lussier, Jacques Grou, Yann Vergriette, Lynda Sauvé, Louis Drouin
Journal: The Lancet (2014)
Cytology of the Urine in Children after Oral Poliovirus Vaccine
Authors: Audrey F. Hart, James D. Cherry, Marie Wartolec
Journal: New England Journal of Medicine (1965)

ALTHOUGH many viruses have been isolated from the urine1 2 3 4 5 6 7 8 9 10 11 during systemic viral illnesses there have been relatively few correlative cytologic investigations of the urinary sediment.6 , 12 , 13 The relation of urinary cells with intranuclear inclusion bodies and cytomegalic inclusion disease is well established.6 , 12 , 14 Recently, cytoplasmic inclusion bodies in urinary cells have been noted in association with various acute viral infections such as measles, rubella, mumps and chicken pox, as well as herpangina and aseptic meningitis.13 , 15 However, similar inclusion-bearing cells have been observed in children and adults, both healthy and with nonspecific pathologic processes.13 , 15 , 16 Binucleated epithelial cells in the urinary sediment have also . . .
Some Points in the Surgical Treatment of Simple Ulcer of the Stomach
Authors: W. F. Haslam
Journal: BMJ (1893)

MWBDIC-L JOURNALI those up to the size of a fist or somewhat larger-is evidently being re- duced to a min-Amum.But with hugc hernie-I meani tlhings like foot- balls or simiall Gladstoine ba.gs-the danger becomes veriy great.This is chiiefly due to the great area of loose cellular tissue opened into in re- miioving the sac.In case 116 a huge volumiie of smiiall guit lhad been down for a very lonig period.It lhad lhypertroplhied to tlle size of average great
Criminal investigation follows report on asbestos compensation fund
Authors: Bob Burton
Journal: BMJ (2004)

A commission of inquiry in Australia has found that James Hardie Industries, a company that made building products containing asbestos until 1987, deliberately underfunded a victims' compensation fund when it undertook a corporate restructuring that limited its asbestos liabilities.

In his report Commissioner David Jackson QC wrote: “The notion that the holding company would make the cheapest provision thought ‘marketable’ in respect of those liabilities so that it could go off to pursue other more lucrative interests insulated from those liabilities is singularly unattractive. Why should the victims and the public bear the cost not provided for?”

In February 2001 the company provided $A292m …
A cluster of seven tightly linked polymorphisms in the IL-13 gene is associated with total serum IgE levels in three populations of white children
Authors: Penelope E. Graves, Michael Kabesch, Marilyn Halonen, Catharine J. Holberg, Mauro Baldini, Christian Fritzsch, Stephan K. Weiland, Robert P. Erickson, Erika von Mutius, Fernando D. Martinez
Journal: Journal of Allergy and Clinical Immunology (2000)
Wet-wrap treatment using dilutions of tacrolimus ointment and fluticasone propionate cream in human APOC1 (+/+) mice with atopic dermatitis
Authors: A.P. Oranje, R. Verbeek, P. Verzaal, I. Haspels, E. Prens, L. Nagelkerken
Journal: British Journal of Dermatology (2008)

Journal Article Wet‐wrap treatment using dilutions of tacrolimus ointment and fluticasone propionate cream in human APOC1 (+/+) mice with atopic dermatitis Get access A.P. Oranje, A.P. Oranje Department of Dermatology and Venereology (Paediatric Dermatology), Erasmus MC, 3015 CE Rotterdam, the Netherlands Correspondence: Arnold P. Oranje. E‐mail: arnold.p.oranje@inter.nl.net; a.p.oranje@erasmusmc.nl Search for other works by this author on: Oxford Academic Google Scholar R. Verbeek, R. Verbeek Department of Inflammatory and Degenerative Diseases, TNO Quality of Life, Leiden, the Netherlands Search for other works by this author on: Oxford Academic Google Scholar P. Verzaal, P. Verzaal Department of Inflammatory and Degenerative Diseases, TNO Quality of Life, Leiden, the Netherlands Search for other works by this author on: Oxford Academic Google Scholar I. Haspels, I. Haspels Department of Inflammatory and Degenerative Diseases, TNO Quality of Life, Leiden, the Netherlands Search for other works by this author on: Oxford Academic Google Scholar E. Prens, E. Prens Department of Dermatology and Venereology (Paediatric Dermatology), Erasmus MC, 3015 CE Rotterdam, the Netherlands Search for other works by this author on: Oxford Academic Google Scholar L. Nagelkerken L. Nagelkerken Department of Inflammatory and Degenerative Diseases, TNO Quality of Life, Leiden, the Netherlands Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 160, Issue 1, 1 January 2009, Pages 54–61, https://doi.org/10.1111/j.1365-2133.2008.08834.x Published: 01 January 2009
Acrogeria (Gottron type): a vascular disorder?
Authors: C. Hashimoto, M. Abe, N. Onozawa, Y. Yokoyama, O. Ishikawa
Journal: British Journal of Dermatology (2004)

We report a 27-year-old Japanese man with the peculiar clinical features of acrogeria. He had had perniosis since early childhood. Prominent atrophic skin changes over the hands, hallux valgus, shortened distal phalanges and atrophic scars on his auricles were noted. X-ray of the hands revealed acro-osteolytic changes of the distal phalanges, and arteriography demonstrated multiple occluded branches of the digital arteries. There were no histological changes of systemic sclerosis in his forearm skin, nor antinuclear antibodies or coagulation disorders. Western immunoblotting demonstrated decreased production of type III collagen by dermal fibroblasts both from an affected finger and from the unaffected upper arm. Although the pathogenesis of acrogeria is unknown, the present case suggests that peripheral circulatory disturbance, as well as a congenital abnormality in type III collagen synthesis, may partly account for the pathogenesis of Gottron-type acrogeria.
Recent Advances: Geriatric Medicine
Authors: R. D Elon
Journal: BMJ (1996)

<h3>Summary points</h3> Exercise has protective effects: it is associated with decreased disability score and decreased rate of myocardial infarction; it is also effective in very old people Multifactorial interventions decrease the likelihood of falls Low body mass considerably increases the risk of hip fracture in older women; other risk factors include alcohol consumption, prior stroke, low activity levels, use of long acting benzodiazepines, large caffeine consumption, and visual impairment Alendronate decreases vertebral fractures in older women and increases bone mass Influenza vaccine is efficacious and cost effective Though the apolipoprotein E4 allele is associated with Alzheimer9s disease, a preventive strategy for Alzheimer9s disease remains a distant goal
Intrahepatic levels and replicative activity of covalently closed circular hepatitis B virus DNA in chronically infected patients
Authors: Andreas Laras, John Koskinas, Evangelini Dimou, Ageliki Kostamena, Stephanos J. Hadziyannis
Journal: Hepatology (2006)

Hepatitis B virus (HBV) covalently closed circular DNA (cccDNA) is responsible for viral persistence in the natural course of chronic HBV infection and during prolonged antiviral therapy and serves as the template for the production of HBV pregenomic RNA (pgRNA), the primary step in HBV replication. In this study, we have developed and applied sensitive and specific quantitative real-time polymerase chain reaction (PCR) assays for the measurement of intrahepatic concentration, pgRNA production, and replicative activity of cccDNA in liver biopsy samples from 34 non-treated patients with chronic hepatitis B (CHB); 12 hepatitis B e antigen (HBeAg)(+) and 22 HBeAg(-). Median copy number for cccDNA was 1.5 per cell and for pgRNA significantly higher, 6.5 copies per cell, with a good correlation between cccDNA and pgRNA levels in all samples. In HBeAg(-) patients, median values of cccDNA and pgRNA levels were 10-fold and 200-fold lower than in HBeAg(+), respectively, reflecting the differences in viral activity and clinical characteristics of the two groups. Furthermore, the replicative activity of intrahepatic cccDNA was significantly lower in HBeAg(-) patients harboring mutant HBV strains than in HBeAg(+) patients: median 3.5 versus 101 pgRNA copies per cccDNA molecule. In conclusion, the levels of both HBV cccDNA, a marker of HBV persistence, and pgRNA, an indicator of viral replication, in the liver of chronically infected patients correlate with viral activity and the phase of HBV infection. The combined measurement of cccDNA and pgRNA levels provides valuable information on the presence and replicative activity of intrahepatic HBV cccDNA.
Diabetes Mellitus in Patients With Gouty Arthritis
Authors: William K. Ishmael, James N. Owens, Richard W. Payne, Mary Duffy Honick
Journal: JAMA (1964)

IT HAS previously been reported that patients with clinical gouty arthritis show a strong familial background of diabetes mellitus.<sup>1</sup>However, none of these patients studied from 1940 to 1942 exhibited concurrent diabetes mellitus themselves. Charcot<sup>2</sup>in 1881, held that the inheritance of a common underlying character could lead to the development of either disease. However, Joslin and associates<sup>3</sup>have reported that only one diabetic out of 1,500 had coexistent gout. In 1957, Weiss, Segaloff and Moore<sup>4</sup>reviewed the English medical literature and could find only five reported instances of gouty arthritis and diabetes mellitus occurring in the same patient. They reported the presence of an elevated fasting blood sugar in 28% of 143 consecutive patients with gout. Only one patient in their series required insulin to control diabetes. They estimated a 50% greater incidence of abnormal carbohydrate metabolism in gouty patients than in a carefully matched
Prevalence and Clinical Significance of Anti–Laminin 332 Autoantibodies Detected by a Novel Enzyme-Linked Immunosorbent Assay in Mucous Membrane Pemphigoid
Authors: Philippe Bernard, Frank Antonicelli, Christophe Bedane, Pascal Joly, Christelle Le Roux-Villet, Sophie Duvert-Lehembre, Patricia Rousselle, Catherine Prost-Squarcioni
Journal: JAMA Dermatology (2013)

<h3>Importance</h3>A rare variant of mucous membrane pemphigoid (MMP) is characterized by circulating anti–laminin 332 (Lam332) autoantibodies and seems to be associated with concurrent malignant neoplasms.<h3>Objective</h3>To determine the prevalence and clinical significance of anti-Lam332 autoantibody detection from a large series of patients with MMP.<h3>Design</h3>Multicenter retrospective study.<h3>Setting</h3>Four French national centers for autoimmune bullous diseases.<h3>Participants</h3>One hundred fifty-four patients with MMP and 89 individuals serving as controls were included.<h3>Interventions</h3>Serum samples were analyzed by a new Lam332 enzyme-linked immunosorbent assay (ELISA); clinical and immunopathologic data were obtained from the patients' medical records.<h3>Main Outcome Measures</h3>The Lam332 ELISA scores were evaluated with respect to clinical characteristics, standard and salt-split indirect immunofluorescence, and bullous pemphigoid (BP) 230 and BP180-NC16A ELISAs.<h3>Results</h3>The Lam332 ELISA score was positive (≥9 U/mL) in 20.1% of serum samples from patients with MMP, 1 of 50 patients with bullous pemphigoid (BP), none of 7 with pemphigus, and 3 of 32 other controls. No relationship was evidenced between a positive ELISA Lam332 score and age; sex ratio; oral, ocular, genital, skin, or esophageal/laryngeal involvement; internal malignant neoplasm; or BP180 ELISA score. Salt-split skin indirect immunofluorescence and ELISA BP230 results were more frequently positive when Lam332 ELISA results were positive (P = .04 and .02, respectively). Patients with a positive Lam332 ELISA score frequently had more severe MMP (67.8% vs 47.2%; P = .04).<h3>Conclusions and Relevance</h3>Results of this novel ELISA showed that serum anti-Lam332 autoantibodies are detected in 20.1% of patients with MMP. Anti-Lam332 autoantibodies are mainly detected in patients with severe MMP but not preferentially in those with a malignant neoplasm. The association between anti-Lam332 and anti-BP230 autoantibodies might arise from an epitope-spreading phenomenon.
The Diagnosis of Gastric Lesions by Intra-Gastric Photography
Authors: REUBEN FINKELSTEIN
Journal: Annals of Internal Medicine (1931)

Article1 January 1931The Diagnosis of Gastric Lesions by Intra-Gastric PhotographyPreliminary Report*REUBEN FINKELSTEIN, M.D., F.A.C.P.REUBEN FINKELSTEIN, M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-4-7-804 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe x-ray examination of the stomach with the barium meal reveals merely a shadow picture of the barium mixture as limited by the gastric walls and borders. Hence, when a defect in the upper or lower border occurs it is filled by this fluid mixture and thus its shadow is outlined. Again, this fluid mass also lends itself to distortion by peristalsis or any irregularity in the stomach wall caused either by an organic disease or a simple spasm of the wall. From the pioneer work of Hemmeter, Rieder, Holzknecht and others it was soon discovered that lesions on the... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Brooklyn, New York*From the Gastro-Intestinal Service of the Medical Department of the Brownsville and East New York Hospital, Dr. Raymond Clark, Chief. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByA review of intragastric photography 1 January 1931Volume 4, Issue 7Page: 804-816KeywordsGastroenterology and hepatologyLesionsPhotographyStomach Issue Published: 1 January 1931 PDF DownloadLoading ...
New Approaches to Cancer Chemotherapy with Methotrexate
Authors: Howard L. Bleich, Emily S. Boro, Emil Frei, Norman Jaffe, Martin H. N. Tattersall, Susan Pitman, Leroy Parker
Journal: New England Journal of Medicine (1975)

THE folic acid antagonists were shown to have antileukemic activity by Farber and his colleagues in 1948.1 Since then the prototypical folic acid antagonist, methotrexate, has been found effective in a number of neoplastic diseases, including choriocarcinoma, head-and-neck cancer and breast cancer. Methotrexate inhibits the enzyme, dihydrofolate reductase, and thus diminishes reduced folate pools, which are essential cofactors, particularly for DNA synthesis, but also for purine and protein synthesis. Citrovorum factor (5-formyl tetrahydrofolate) supplies the product of the inhibited enzyme and thus can prevent, and when employed appropriately can rescue cells from, adverse biologic effects in in vitro and in . . .
SAFETY AND EFFICACY OF ANGIO-SEAL™ VASCULAR CLOSURE DEVICE FOLLOWING PERCUTANEOUS CORONARY INTERVENTION
Authors: Abdelazim Hashim, Naoyo Mori, Satish Velagapudi, Babak Haddadian, Raaid Museitif, Angela Schlemm, Suhail Allaqaband, Tanvir Bajwa, Anjan Gupta
Journal: Journal of the American College of Cardiology (2010)
An evaluation of dermoscopy fluids and application techniques
Authors: A.J. Gewirtzman, J-H. Saurat, R.P. Braun
Journal: British Journal of Dermatology (2003)

Dermoscopy, a noninvasive technique used to help physicians better visualize pigmented skin lesions, is becoming widely used by dermatologists. Yet despite its popularity, to our knowledge basic aspects such as the best immersion fluid (IF) to use and proper procedures for applying the IF and dermatoscope have never been the subject of a systematic investigation.To determine the best techniques for application of IF and the dermatoscope; to discover which IF results in the least amount of air inclusions; to determine which IF provides the best image quality.This study was divided into three phases. Phase I examined several techniques of taking digital dermoscopic photographs in an attempt to eliminate air bubbles. Phase II tested seven IFs to analyse quantitatively the number of air inclusions for each IF. Phase III investigated these same IFs to judge the image quality for each.Phase I: in our hands, the best technique to apply an IF is to use an eyedropper and place the IF directly onto the skin in combination with a 'roll-on technique': the dermatoscope's edge is placed on the skin first and is then rotated until the glass plate lies flat against the skin. Phase II: the alcoholic IF resulted in the least amount of air bubble inclusions (70% ethanol, 90% isopropanol and alcoholic disinfectant), while liquid paraffin (a mineral oil) resulted in the most air bubbles. Phase III: dermoscopic structures were equally clear with alcohols and liquid paraffin, but slightly blurry with ultrasound gel and water.Although 90% isopropanol performed slightly better in terms of air inclusions, we prefer to use 70% ethanol in most circumstances because it has the advantage of being odourless, unlike its counterpart. Additionally, ethanol will not stain clothing, does not crystallize on the dermatoscope, disinfects and evaporates immediately (does not need to be wiped off). For certain local considerations, such as dermoscopy on mucosa or the nail, we prefer to use ultrasound gel because it will not flow.
In vitro and in vivo evaluation of therapy targeting epithelial-cell adhesion-molecule aptamers for non-small cell lung cancer
Authors: Mona Alibolandi, Mohammad Ramezani, Khalil Abnous, Fatemeh Sadeghi, Fatemeh Atyabi, Mohsen Asouri, Ali Asghar Ahmadi, Farzin Hadizadeh
Journal: Journal of Controlled Release (2015)
The Family and Human Adaptation. Three Lectures [Presented as the Mona Bronfman Sheckman Lectures in Social Psychiatry at Tulane University, New Orleans, Louisiana, February 23 and 24, 1961]
Authors: Battle S. Searcy
Journal: JAMA (1964)

The changing role of the family in our civilization offers opportunities to explore personality development and aberrations. In three brief, cohesive lectures addressed to psychiatrists, anthropologists, psychologists, and sociologists, a distinguished professor examines this general theme. Industrialization and urbanization have led to an isolated "nuclear" family, of parents and children, in contrast to the large "extended kinship" family of past generations. Emergence of this nuclear family, fulfillment of the spouses' needs within this setting, and proper development of offspring introduce the theme in the first lecture. That the family is a social institution, mediating between the biological and cultural determinants of personalityformation, carries the opening thesis into the second lecture. As the family gains structure from parental interaction, the children gain useful ways of environmental adaptation. If we compare family life within family groups and then within cultural settings, we can isolate factors pertinent to personality disorder. In the third
Abstract LB-247: Circulating proteolytic products of tumor-resident enzyme as potential biomarkers for early detection of breast cancer
Authors: Ye Hu
Journal: Cancer Research (2014)

Abstract In theory, any or all of tumor-secreted proteins can serve as cancer biomarkers. However, the reality is challenging to monitor because of the large degree of fluctuation in abundance and localization of these tumor-secreted proteins, especially in the early stage of tumor development and/or metastasis. As such, it seems feasible that we might take advantage of the fact that secreted proteases/peptidases in the tumor microenvironment generate proteolytic products, also referred to as “circulating peptides”, which are detectable in bloodstream and provide ample information about the body, “coded” in the patterns and quantity of these peptides. Herein we clearly link the catalytic activity of Carboxypeptidase N (CPN) to its proteolytic products during breast tumor progression in mouse model and clinical samples. CPN plays important roles in regulating vasoactive peptide hormones, growth factors, and cytokines by specifically cleaving their C-terminal basic residues. Circulating fragment profiling, by an approach combining nanopore fractionation and mass spectrometry, revealed the nature and extent of cleavage by CPN. These results correlated with the level of CPN-catalyzed peptides in blood taken from the tumor-bearing mice, healthy women and breast cancer patients. We showed that generation of C3f_R1310-L1319 specifically correlated with the CPN expression level. In both mouse and clinical patient samples, the amount of CPN was increased in tumor tissues compared to that seen in normal breast tissue, while its counterpart in blood remained constant. The amount of 6 CPN-catalyzed peptides predominantly increased in sera taken from both the mice at 2 weeks after orthotropic implantation and the patients’ plasma as early as the first pathologic stage of breast cancer. In conclusion, the circulating level of the selected 6 CPN-catalyzed proteolytic products reflects the extent of this enzyme's activity in tumors, and our results clearly indicate their strong potential as biomarkers for non-invasive early diagnosis of breast cancer. Citation Format: Ye Hu. Circulating proteolytic products of tumor-resident enzyme as potential biomarkers for early detection of breast cancer. [abstract]. In: Proceedings of the 105th Annual Meeting of the American Association for Cancer Research; 2014 Apr 5-9; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2014;74(19 Suppl):Abstract nr LB-247. doi:10.1158/1538-7445.AM2014-LB-247