CLINICAL STUDIES WITH THE AID OF RADIO-PHOSPHORUS. IV. THE RETENTION IN BLOOD, THE EXCRETION AND THE THERAPEUTIC EFFECT OF RADIO-PHOSPHORUS ON PATIENTS WITH LEUKEMIA
Authors: L. A. Erf, L. W. Tuttle, J. H. Lawrence
Journal: Annals of Internal Medicine (1941)

Article1 September 1941CLINICAL STUDIES WITH THE AID OF RADIO-PHOSPHORUS. IV. THE RETENTION IN BLOOD, THE EXCRETION AND THE THERAPEUTIC EFFECT OF RADIO-PHOSPHORUS ON PATIENTS WITH LEUKEMIAL. A. ERF, M.D., L. W. TUTTLE, J. H. LAWRENCE, M.D.L. A. ERF, M.D.Search for more papers by this author, L. W. TUTTLESearch for more papers by this author, J. H. LAWRENCE, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-15-3-487 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptPrevious studies19, 20, 21, 22, 34, 35have shown that radiophosphorus (15P32) (which owes its radioactivity to the spontaneous emission of beta rays) when administered in the form of sodium phosphate, at first concentrates in the bone marrow and those tissues infiltrated with leukemic cells and later concentrates in the osseous tissues. Radio-phosphorus has been used as a therapeutic agent during the past three years in all types of leukemia, with encouraging results. The principal advantages offered by radio-phosphorus appear to lie in its ease of administration (it may be given orally, intravenously, etc.), in its therapeutic effectiveness and in...References1. BLUMCOMBS LS: Chronic lymphatic leukemia complicated by Type III pneumococcus pneumonia. Recovery from pneumonia with sulfapyridine and serum, Jr. Indiana State Med. Assoc., 1940, 424. Google Scholar2. BRUES DT: Food, drink and evolution, Science, 1939, xc, 145. CrossrefGoogle Scholar3. CASTLEMEYERCHEW WBOOWB: Negative results of treatment of chronic myelogenous leukemia as a deficiency disease, Proc. Soc. Exper. Biol. and Med., 1935, xxxii, 660. CrossrefGoogle Scholar4. CRAVERMACCOMB LFWS: Irradiation of entire body; Heublein method, N. Y. State Jr. Med., 1934, xxxiv, 249. Google Scholar5. ERF LA: Clinical studies with the aid of radio-phosphorus. II. 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PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byProposed biokinetic model for phosphorusAppendixesBIBLIOGRAPHYAppendixesDer Einfluß der Phosphor-Aufnahme auf die Ausscheidung und Retention von parenteral verabreichtem 32P nach Untersuchungen an ausgewachsenen SchweinenHistorische Übersicht der Anwendung von IsotopindicatorenBlutkrankheitenAn evaluation of the effect of pregnancy on chronic granulocytic leukemiaÜber die Resorption von anorganischen Stoffen durch die menschliche HautDer Mineralstoffwechsel der ZelleUPTAKE OF RADIOPHOSPHATE IN THYROID AND LYMPHATIC TISSUE OF YOUNG GUINEA PIGS AFTER SUBTOTAL THYMECTOMYBlutkrankheitenPhosphorusTierversuche über Aufnahme und Verteilung von radioaktivem PhosphatRadioactive phosphorus. II. In the treatment of myeloid leukemiaBibliographyMULTIPLE MYELOMA: A STUDY OF 24 PATIENTS TREATED WITH RADIOACTIVE ISOTOPES (P32 AND SR88)*JOHN H. LAWRENCE, M.D., LOUIS R. WASSERMAN, M.D., F.A.C.P.The effect of temperature upon the uptake of radioactive phosphate by human erythrocytes in vitroThe biological half-life of radioactive phosphorus in the blood of patients with leukemia.III. Erythrocytes—with deviations of observations from predicted valuesThe biological half-life of radioactive phosphorus in the blood of patients with leukemia.IV. Leukocytes—radioactive phosphorus content and the relation to plasma-P32 levelsThe biological half-life of radioactive phosphorus in the blood of patients with leukemia.I. Whole blood—with deviations of observations from predicted values and an estimate of total-phosphorus turnover rateAnwendungen der stabilen und radioaktiven Isotope in der BiochemieRadiophosphorus in the Treatment of Blood DyscrasiasRadioactive Phosphorus (P32) and Alkylamines (Nitrogen Mustards) in the Treatment of Neoplastic and Allied Diseases of the Hemofoietic SystemLeucemia and Pregnancy 1 September 1941Volume 15, Issue 3Page: 487-543KeywordsAIDSBloodBone marrowCellsChildrenExcretionPhosphatesRadiation therapyResearch laboratoriesSodium ePublished: 1 December 2008 Issue Published: 1 September 1941 PDF downloadLoading ...