tbuckley/cabot-search huggingface dataset:
Abstract 17827: Klf5 Mediates Glucose-driven Changes ofCcardiac Pparα in Diabetes
Authors: Konstantinos Drosatos, Nina M Pollak, Florian Willecke, Panagiotis Ntziachristos, Chad M Trent, Yunying Hu, P. Christian Schulze, Iannis Aifantis, Ira J Goldberg
Journal: Circulation (2014)

Krüppel-like factors (KLF) affect metabolism. Lipopolysaccharide-induced sepsis reduced cardiac PPARα and increased KLF5 (8-fold) more than any cardiac KLF isoform detected by whole genome microarray analysis. In silico analysis of ppara gene promoter predicted two KLF5 binding sites that overlap with c-Jun (AP-1) binding sites: -792/-772 bp and -719/-698 bp. Infection of a mouse cardiomyocyte cell line (HL-1) with adenovirus expressing constitutively active c-Jun reduced, while Ad-KLF5 increased PPARα mRNA in a dose-dependent manner. Chromatin immunoprecipitation (ChIP) showed that c-Jun binds both -792/-772 bp and -719/-698 on ppara promoter while KLF5 binds on -792/-772 bp. ChIP on LPS-treated HL-1 cells showed that c-Jun binding on -792/-772 bp prohibits KLF5 binding. We generated a cardiomyocyte-specific KLF5 knockout mouse (αMHC-KLF5-/-), which had 50% normal cardiac function. Cardiomyocyte-specific KLF5 ablation reduced PPARα (50%) and several fatty acid metabolism-associated genes such as CD36 (40%), LpL (20%), PGC1α (45%), AOX (28%) and Cpt1 (45%). As PPARα regulates cardiac fatty acid metabolism, we tested whether cardiac KLF5 is modulated in diabetes, when cardiac PPARα and lipid changes occur. I.p. injection of streptozotocin (STZ) in C57BL/6 mice increased plasma glucose (2.9-fold) and reduced cardiac KLF5 and PPARα gene expression; similar to STZ-treated rats but unlike what had been found in a different mouse strain (C57BL/6 x DBA2) treated with STZ. Treatment of HL-1 cells with increased glucose-containing medium (1 mg/ml) reduced KLF5 (80%) and PPARα (65%), as well as fatty acid metabolism markers, such as AOX (85%), Cpt1β (70%), LCAD (80%) and VLCAD (85%). On the other hand GLUT1 and GLUT4 were increased (30% and 20%) and PDK4 was reduced (65%) indicating increased glucose utilization. A model of non-insulin dependent hyperglycemia (ob/ob mice) had reduced cardiac KLF5 (60%) and PPARα (65%). Correction of hyperglycemia in STZ-treated C57BL/6 mice by pharmacological (dapagliflozin) or antisense oligonucleotide inhibition of kidney’s sodium glucose transporter 2 (SGLT2), restored KLF5 and PPARα gene expression. Thus, KLF5 is a transcriptional regulator of cardiac PPARα that is driven by changes in plasma glucose levels
Australian GPs to pay £50 000 for wrong diagnosis
Authors: Christopher Zinn
Journal: BMJ (2001)

In Australia two brothers who practised as GPs have been ordered to pay substantial damages to a patient in whom they diagnosed terminal cancer, with only 12 months to live, when in fact he was perfectly healthy.

Mr Maxwell Husband consulted Dr Michael Bar-Mordecai in May 1995 with a back injury, and after an x ray examination he was told he had cancer of the spine, lungs, and colon and that chemotherapy would be hopeless. For the next two years Mr Husband, who was …
The serotonin syndrome
Authors: H Sternbach
Journal: American Journal of Psychiatry (1991)

A review of the literature on the serotonin syndrome in animals and human beings was conducted, and 12 reports of 38 cases in human patients were then analyzed to determine the most frequently reported clinical features and drug interactions, as well as the incidence, treatment, and outcome of this syndrome.The serotonin syndrome is most commonly the result of the interaction between serotonergic agents and monoamine oxidase inhibitors. The most frequent clinical features are changes in mental status, restlessness, myoclonus, hyperreflexia, diaphoresis, shivering, and tremor. The presumed pathophysiological mechanism involves brainstem and spinal cord activation of the 1A form of serotonin (5-hydroxytryptamine, or 5-HT) receptor. The incidence of the syndrome is not known. Both sexes have been affected, and patients' ages have ranged from 20 to 68 years. Discontinuation of the suspected serotonergic agent and institution of supportive measures are the primary treatment, although 5-HT receptor antagonists may also play a role. Once treatment is instituted, the syndrome typically resolves within 24 hours, but confusion can last for days, and death has been reported.The serotonin syndrome is a toxic condition requiring heightened clinical awareness for prevention, recognition, and prompt treatment. Further work is needed to establish the diagnostic criteria, incidence, and predisposing factors, to identify the role of 5-HT antagonists in treatment, and to differentiate the syndrome from neuroleptic malignant syndrome.
Evaluation of respiratory symptoms in children with post-infectious bronchiolitis obliterans
Authors: Neslihan Baranoglu Him, Ihsan Turan, Yasemin Gokdemir, Refika Ersu, Bulent Karadag, Fazilet Karakoc
Journal: European Respiratory Journal (2011)

Background:  Bronchiolitis obliterans (BO) is an uncommon and severe form of chronic obstructive lung disease in children that results from an insult to the lower respiratory tract. The aim of this study was to evaluate the respiratory symptoms of BO patients and determine related factors.   Methods:  Retrospective evaluation of BO patients who were followed-up from pediatric pulmonology department.   Results:  Total of 22 patients (63% male) were included to the study. Mean age was 9.1±3.8 years. During first lower respiratory tract infection, mechanical ventilation and 0 2  was required in 32% and 9% of patients, respectively. Eighty percent of patients were treated with inhaled or oral steroids in the early period. Respiratory symptoms were recurrent in 35% and persistent in 65% of patients after the first lung infection. The age of 11 (50%) patients were above six currently and performed spirometry; mean FEV 1  was 51.-00±16.5% predicted. Right upper lobectomy was performed in one patient. Four (18%) patients were using 0 2  and one patient was using non-invasive ventilation (NIV) at the last visit. The rate of intubation during the first lung infection was 80% in the patients who required respiratory support in the follow-up period. There was a significant relationship with intubation during the first lower respiratory infection and requirement of 0 2  ve NIV (p=0.001) in the follow-up period.   Conclusion:  BO is a disease of childhood with high morbidity and mortality. The severity of the respiratory symptoms of patients during follow-up is associated with the requirement of mechanical ventilation during the first lower respiratory infection.
Idiopathic first seizure in adult life.
Authors: Cees van Donselaar
Journal: BMJ (1991)

textabstractThis thesis is based on a prospective investigation of 226 patients aged 15
years and older, who were referred to one of the participating hospitals
due to a possible idiopathic first seizure. Only those patients were admitted
to the study in whom an obvious cause on clinical grounds for the occurrence
of the seizure was lacking. A standard EEG, an EEG after partial sleep
deprivation and a computerised tomography scan (CT scan) were obtained
in all patients. None of the patients were treated with antiepileptic drugs,
unless a second seizure occurred. Follow-up in all patients was 1 - 2 years.
A New Federal-State Partnership in Health Care
Authors: Ezekiel Emanuel, Ron Wyden
Journal: JAMA (2008)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Transcatheter Closure of Perimembranous Ventricular Septal Defects Using the New Amplatzer Membranous VSD Occluder
Authors: Yun-Ching Fu, John Bass, Zahid Amin, Wolfgang Radtke, John P. Cheatham, William E. Hellenbrand, David Balzer, Qi-Ling Cao, Ziyad M. Hijazi
Journal: Journal of the American College of Cardiology (2006)
Local Recurrence and Ocular Adnexal Complications Following Electronic Surface Brachytherapy for Basal Cell Carcinoma of the Lower Eyelid
Authors: Kian Eftekhari, Richard L. Anderson, Gita Suneja, Anneli Bowen, Thomas J. Oberg, Glen M. Bowen
Journal: JAMA Dermatology (2015)

Various treatment options exist for nonmelanoma skin cancer (NMSC), including topical agents, surgery, or definitive or adjuvant radiation therapy. Recently, electronic surface brachytherapy (ESB) has been described as a noninvasive option for NMSC. We report a case of local recurrence of basal cell carcinoma (BCC) and ocular complications following ESB to the lower eyelid.A man in his 60s presented with a recurrent BCC within the radiation field 10 months after undergoing ESB for a biopsy-proven BCC. In addition to the recurrence, he had contracture of the conjunctiva in the socket of his previously enucleated eye, as well as lower eyelid ectropion, resulting in displacement and loss of retention of his ocular prosthesis.Electronic surface brachytherapy should be used with caution, particularly in the periocular region because the late effects of hypofractionated radiation may cause ocular and orbital complications. To our knowledge, this is the first reported case of ocular complications with this modality. This case highlights a local recurrence following use of this new treatment modality, suggesting further investigation is warranted to determine the safety and efficacy of ESB.
The Relation of Psychiatry to Medicine
Authors: Austen Fox Riggs
Journal: Annals of Internal Medicine (1929)

Article1 October 1929The Relation of Psychiatry to MedicineAUSTEN FOX RIGGS, M.D.AUSTEN FOX RIGGS, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-3-4-360 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe relation of psychiatry to medicine has, until quite recent years, been very unimportant, extremely tenuous, and quite unsatisfactory. Psychiatry has been considered, and with considerable justification, a very poor relation of medicine. This conception of its status is, however, largely a thing of the past, and as psychiatry itself has advanced, so also has its relation to general medicine. As a matter of fact I am not sure that further improvements in this relationship, to be immediately expected, will not have to come from the other side of the fence, so to speak, that is, from general medicine itself.... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Stockbridge, Mass.*Presented at the Boston meeting of the American College of Physicians, April 9, 1929. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 October 1929Volume 3, Issue 4Page: 360-365 ePublished: 1 December 2008 Issue Published: 1 October 1929 PDF downloadLoading ...
Abstract 19474: Clinical Characteristics and Outcomes of Patients With and Without Diabetes in the Surgical Treatment for Ischemic Heart Failure (STICH) trial
Authors: Michael R MacDonald, Lilin She, Torsten Doenst, Philip Binkley, Jean Rouleau, Tan San, Kerry Lee, George Sopko, Dominika Szalewski, Eric Velazquez, Mark C Petrie
Journal: Circulation (2014)

Introduction: Diabetes mellitus (DM), coronary artery disease (CAD) and heart failure commonly coexist. Hypothesis 1 of the Surgical Treatment for Ischemic Heart Failure (STICH) trial enrolled 1212 patients with a left ventricular ejection fraction (LVEF) of 35% or less and CAD amenable to CABG. Patients were randomised to CABG and optimal medical therapy (OMT) or OMT alone. Hypothesis: We assessed the hypothesis that patients with DM enrolled in the STICH trial would have greater benefit of CABG than patients without DM. Methods: We compared the characteristics and clinical outcomes of patients with and without DM randomized to CABG and OMT or OMT alone. Cox-proportional hazards analyses were used to assess treatment effect. Results: Diabetes was present in 40.3%. At baseline, patients with DM had more triple vessel CAD (66% v 57%, p&lt;0.001), higher LVEF [median 29% (IQR:22,35) vs 27% (IQR:22,33), p=0.015] and smaller left ventricular end diastolic volume index [median 105 ml/m2 (IQR:85, 128) vs 117 ml/m2 (IQR:93, 146) (p&lt;0.001)]. Among patients with DM, there was a higher proportion of females, higher BMI on average, worse renal function, and more hypertension. Patients with DM undergoing CABG spent longer on cardio-pulmonary bypass [median 97 (IQR:71,126) vs 87 (IQR:65, 115) minutes, p=0.029], and were more likely to develop perioperative AF (23% vs 11%, p&lt;0.001) and worsening renal function (9% vs 4%, p=0.021). Patients with DM on OMT had similar outcomes as those on OMT without diabetes (Table 1). A statistically significant or near statistically significant improvement in clinical outcomes with CABG compared to OMT was documented in patients without DM, but not in patients with DM. However, there was no significant interaction between DM and treatment group on formal statistical testing. Conclusions: Patients with and without DM enrolled in the STICH trial had similar outcomes at 5 years, and CABG did not exert greater benefit in patients with DM.
Abstract A20: Deregulation of cell cycle and apoptotic mechanisms in UVB-irradiated p16-mutant inducible melanoma cell lines
Authors: Allal Ouhtit, Ishita Gupta, Zakariya Y. Abd Elmageed, Therese M. Becker
Journal: Cancer Research (2015)

Abstract Melanoma is the deadliest skin cancer as it progresses to a highly aggressive and metastatic tumor during melanomagenesis. However, its underlying mechanisms regulating melanoma-genesis remain nascent. Our previous studies have demonstrated that the p53 and p16INK4a sub-pathways components of the Rb-signaling pathway, plays a critical role in UVB-induced skin cancer. The aim of this study was to study the molecular changes in the expression/function of the different components of the Rb signaling pathway associated with UVB-induced cell cycle and apoptotic programs. Pursuant to this goal, normal melanocytes, and a panel of p16-induced cell lines (wild-type p16INK4a-inducible clone p16wt-A4, and the N-terminal 8 amino-acid duplication p16INK4a-inducible clone p16Dp1 (+24 base pairs) were used to elucidate the early molecular events especially associated with the p16INK4a/Rb-signaling pathway regulating cell-cycle and apoptotic responses. Our results showed that: 1) in the menlanocytes high UVB dose induced p16 but not p53, and the Bax/Bcl2 ratio was also increased, suggesting that the cells had selected to undergo apoptosis in a p53-independent manner; 2) In the wt-p16 melanoma cells however, while low UVB irradiation upregulated p16, high dose reduced p16 expression and abrogated Cdk6 but not Cdk4; 3) Interestingly, mutant-p16 melanoma cells over-expressed cell cycle proteins Cdk4/6 and pRb proteins upon p16 induction, however, UVB exposure did not affect this increase; and 4) The anti-apoptotic properties of mutant cells were predominant at high dose of exposure associated with a decrease in Bax and an increase in Bcl2 expression. These data put together, suggest that the mutant p16 dictate cell cycle deregulation and causes resistance of melanoma cells to apoptosis. In conclusion, our study shows that UVB radiation-induced deregulation of p16INK4a/Cdk4 sub-pathway is a critical early event in melanomagenesis. Citation Format: Allal Ouhtit, Ishita Gupta, Zakariya Y. Abd Elmageed, Therese M. Becker. Deregulation of cell cycle and apoptotic mechanisms in UVB-irradiated p16-mutant inducible melanoma cell lines. [abstract]. In: Proceedings of the AACR Special Conference on Advances in Melanoma: From Biology to Therapy; Sep 20-23, 2014; Philadelphia, PA. Philadelphia (PA): AACR; Cancer Res 2015;75(14 Suppl):Abstract nr A20.
Invasive Pneumococcal Disease Following the Introduction of 13-Valent Conjugate Vaccine in Children in New York City From 2007 to 2012
Authors: Andrea C. Farnham, Christopher M. Zimmerman, Vikki Papadouka, Kevin J. Konty, Jane R. Zucker, Geetha V. Nattanmai, Sherly Jose, Jennifer B. Rosen
Journal: JAMA Pediatrics (2015)

Invasive pneumococcal disease (IPD) is a leading cause of pneumonia, meningitis, and bacteremia in children. In March 2010, a 13-valent pneumococcal conjugate vaccine (PCV13) was introduced to the routine childhood immunization schedule. The PCV13 contains 6 serotypes not included in the previously recommended 7-valent pneumococcal conjugate vaccine, including serotype 19A, the predominant cause of IPD prior to the introduction of PCV13.To describe changes in the epidemiology and incidence of IPD in children younger than 5 years in New York City (NYC) after the introduction of PCV13 and assess PCV13 coverage in NYC.Retrospective analysis of population-based IPD surveillance data of the general population residing in NYC between January 1, 2007, and December 31, 2012. Invasive pneumococcal disease cases were identified by laboratory reporting of positive pneumococcal cultures from a normally sterile body site in NYC residents younger than 5 years. Isolates were serotyped. Participants included 468 cases younger than 5 years with IPD reported through routine surveillance to the NYC Department of Health and Mental Hygiene.Absolute differences and percentage changes in IPD incidence before and after the introduction of PCV13 by serotype grouping, age, and race/ethnicity. The number of PCV13 doses administered to children younger than 5 years was calculated using the NYC immunization information system.There were 468 IPD cases from 2007 to 2012. The incidence of IPD decreased by 69.6% (95% CI, -79.3% to -55.5%) from 21.0 cases per 100 000 (2007-2009 mean) pre-PCV13 to 6.4 cases per 100 000 (2011-2012 mean) post-PCV13. Estimates of disease caused by serotypes included in the PCV13 decreased by 82.5% (95% CI, -90.0% to -69.3%), including a 79.7% reduction in serotype 19A (95% CI, -89.0% to -62.4%). Reductions in IPD incidence were seen in all age groups, with the largest reduction in children younger than 12 months (80.4%; P = .005). Incidence decreased significantly in all racial/ethnic groups. The percentage of children younger than 5 years in NYC with 1 or more doses of PCV13 increased from 47.8% in 2010 to 89.8% in 2012.The incidence of IPD in NYC children younger than 5 years and, particularly, the incidence of IPD caused by serotype 19A decreased dramatically following the introduction of PCV13, with reductions among all age and racial/ethnic groups. This represents a significant achievement for public health immunization programs and underscores the importance of achieving high immunization coverage.
Cities and Space: The Future Use of Urban Land. Essays from the Fourth RFF Forum.
Authors: Lowdon Wingo, Melvin M Webber, Stanley B Tankel
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Resting-State Functional Connectivity in Psychiatric Disorders
Authors: Neil D. Woodward, Carissa J. Cascio
Journal: JAMA Psychiatry (2015)

The idea that serious mental illnesses such as autism and schizophrenia result from abnormal connectivity of large-scale brain networks is gaining widespread acceptance. Efforts to test dysconnectivity hypotheses have historically been hindered by tools with insufficient spatial resolution to investigate human brain connectivity in vivo and an incomplete understanding of the large-scale organization of the brain, the so called “connectome.” The development of resting-state functional connectivity MRI (rs-fcMRI) has profoundly affected our understanding of the functional organization of the brain, both in health and illness. The investigation by Cerliani and coauthors in this issue reports abnormal cortical-subcortical connectivity in autism1. In this editorial, we briefly review rs-fcMRI methods, summarize several key rs-fcMRI findings in two exemplary dysconnectivity psychiatric illnesses, schizophrenia and autism, and discuss the potential usefulness of rs-fMRI in the search for biomarkers of psychiatric disorders.
John Paul Stapp, MD, PhD
Authors: Phil Gunby
Journal: JAMA (2000)

Air Force researcher who subjected himself to huge gravitational forces in the study of human endurance when exposed to supersonic maneuvering and mishaps, died November 13, 1999, at his home in Alamagordo, NM, at age 89.Beginning in the immediate post-World War II years, he volunteered to be strapped into rocket-powered steel research sleds on concrete-embedded tracks to determine human tolerance to acceleration and deceleration forces.His findings are credited with playing a key role in proving that humans can operate vehicles traveling through space at ever-increasing speeds and can escape from them in an emergency.On the ground, for the general public, his data were critical for today's standard supplying of seat belts and air bags in most US motor vehicles.The son of American missionaries, Stapp was born in Bahia, Brazil.After high school in Texas, he became an English major at Baylor University there.Then, when called upon to help nurse a 2-year-old cousin, who had been burned when the boy came too close to an open fireplace, Stapp resolvedafter witnessing the child's death-to become a physician.However, family finances were limited and he had to undertake a variety of jobs to stay in college, finally earning a PhD degree from the University of Texas.In 1939, at age 29, he was admitted to the University of Minnesota Medical School.Like most physicians graduating in the early 1940s, Stapp entered wartime military medical service.He was preparing to return to civilian life from a variety of US Army Air Corps medical assignments when 2 developments changed his decision.First, the military was designing aircraft that could fly faster and higher than ever before, but it was unknown whether humanscouldtoleratesuchstresses,much less escape in an emergency.(About the