MACROGLOBULINEMIA: REPORT OF TWO CASES
Authors: H GLENCHUR, H H ZINNEMAN, D R BRIGGS
Journal: Annals of Internal Medicine (1958)

Article1 May 1958MACROGLOBULINEMIA: REPORT OF TWO CASESHARRY GLENCHUR, M.D., HORACE H. ZINNEMAN, M.D., F.A.C.P., DAVID R. BRIGGS, Ph.D.HARRY GLENCHUR, M.D.Search for more papers by this author, HORACE H. ZINNEMAN, M.D., F.A.C.P.Search for more papers by this author, DAVID R. BRIGGS, Ph.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-48-5-1055 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptIn 1944 Waldenström presented his paper on "Incipient Myelomatosis or 'Essential' Hyperglobulinemia with Fibrinogenopenia—A New Syndrome?" In it he described three patients with refractory anemia and bleeding tendency whose sera exhibited a very high viscosity. Waldenström speculated that a special globulin fraction was the cause of the increased viscosity, and by ultracentrifugation studies he was able to demonstrate that the sera of two of these patients contained macroglobulins with molecular weights of over 1,000,000.1Since then other reports have been published, mostly from Europe, of single cases or small series, with a similar clinical picture and the presence of macroglobulins...Bibliography1. Waldenström J: Incipient myelomatosis or "essential" hyperglobulinemia with fibrinogenopenia—a new syndrome? Acta med. Scandinav. 117: 216, 1944. CrossrefGoogle Scholar2. WildeHitzelberger HAL: Macroglobulinemia—clinical features and differential diagnosis, Blood 9: 875, 1954. CrossrefMedlineGoogle Scholar3. JimSteinkamp RTRC: Macroglobulinemia and its relationship to other paraproteins, J. Lab. and Clin. Med. 47: 540, 1956. MedlineGoogle Scholar4. Waldenström J: Zwei interessante Syndrome mit Hyperglobulinämie, Schweiz. med. Wchnschr. 78: 927, 1948. MedlineGoogle Scholar5. Schaub F: Zum Krankheitsbild und zur Differentialdiagnose der Makroglobulinämie, Waldenström, Schweiz. med. Wchnschr. 82: 890, 1952. MedlineGoogle Scholar6. TischendorfHartman WF: Makroglobulinaemie (Waldenström) mit gleichzeitiger Hyperplasie der Gewebsmastzellen, Acta haemat. 4: 375, 1950. CrossrefGoogle Scholar7. Dörken H: Primäre und sekundäre Purpura hyperglobulinaemica, Acta haemat. 10: 340, 1953. CrossrefMedlineGoogle Scholar8. Schaub F: Gleichzeitiges Vorkommen von Makroglobulinämie Waldenström und von malignen Tumoren, Schweiz. med. Wchnschr. 83: 1256, 1953. MedlineGoogle Scholar9. MacKayEriksenMotulskyVolwiler IRNAGW: Cryo- and macroglobulinemia—electrophoretic, ultracentrifugal and clinical studies, Am. J. Med. 20: 564, 1956. CrossrefMedlineGoogle Scholar10. LongRiopelleFrancoeurParéPoirierGeorgescoColpron LAJLMAPMG: Macroglobulinaemia—effect of macroglobulins on prothrombin conversion accelerators, Canad. M. A. J. 73: 726, 1955. MedlineGoogle Scholar11. BraunsteinerFalknerNeumayerPakesch HRAF: Makromolekuläre Cryoglobulinämie, Klin. Wchnschr. 32: 722, 1954. CrossrefMedlineGoogle Scholar12. Mandemavan der SchaafHuisman EPCTH: Investigations on the aminoacid composition of a macroglobulin and a cryoglobulin, J. Lab. and Clin. Med. 45: 261, 1955. MedlineGoogle Scholar13. ZinnemanHall HHWH: Recurrent pneumonia in multiple myeloma and some observations on immunologic response, Ann. Int. Med. 41: 1152, 1954. LinkGoogle Scholar14. Waldenström J: Pathological globulins and protein synthesis, Exper. Med. and Surg. 12: 187, 1954. MedlineGoogle Scholar15. Kanzow U: Die Makroglobulinämie Waldenström, Klin. Wchnschr. 32: 154, 1954. CrossrefMedlineGoogle Scholar16. WilliKollerRaaflaub HFJ: Symptomatische Makroglobulinämie bei Lues congenita, Acta haemat. 11: 316, 1954. CrossrefMedlineGoogle Scholar17. OncleyScatchardBrown JLGA: Physicochemical characteristics of certain of the proteins of normal human plasma, J. Physiol. and Colloid Chem. 51: 184, 1947. CrossrefMedlineGoogle Scholar18. Edsall JT in The proteins, by Neurath, H., and Bailey, K., Vol. 1, Part B, 1953, Academic Press, New York, p. 639. Google Scholar19. VoigtFrick AEPG: Macroglobulinemia of Waldenström: a review of the literature and presentation of a case, Ann. Int. Med. 44: 419, 1956. LinkGoogle Scholar20. PetermannBraunsteiner MLH: A cryoglobulin of high sedimentation rate (macroglobulin) from human serum, Arch. Biochem. 52: 491, 1954. CrossrefGoogle Scholar21. MacKayMotulskyVolwiler NEAGW: Cryo- and macroglobulinemia: electrophoretic, ultracentrifugal and clinical studies, Clin. Res. Proc. 3: 104, 1955. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Minneapolis, Minnesota*Received for publication February 18, 1957.From the Veterans Administration Hospital, Minneapolis, Minnesota, the Department of Medicine, University of Minnesota Medical School, and the Department of Biochemistry, Institute of Agriculture, University of Minnesota.Requests for reprints should be addressed to Horace H. Zinneman, M.D., Veterans Administration Hospital, Minneapolis 17, Minnesota. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByNineteen-year follow-up of Waldenström's-associated neuropathy and Bing-Neel syndromeEffect of penicillamine on the titre of the rheumatoid factor: a historical perspective.Ocular manifestations of multiple myeloma, Waldenström's macroglobulinemia and benign monoclonal gammopathyWaldenström's Macroglobulinemia and Mononeuritis MultiplexE. WAYNE MASSEY, A. 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GANTZ-MANDELL, B.A.Immunochemical Properties of Cold HaemagglutininsTreatment of Malignant Diseases Associated with Gamma Globulin AbnormalitiesMACROGLOBULINEMIA OF WALDENSTRÖM-REPORT OF A CASE WITH FEW SYMPTOMS: BRIEF REVIEW OF THE LITERATUREHeterogenity of γ-GlobulinsParaprotein�mie mit vier verschiedenen MakroglobulinkomponentenSimple Paper Electrophoretic Method for detecting MacroglobulinæmiaWaldenström's macroglobulinemiaReactions of serum proteins with a sulfhydryl compound during electrophoresisTreatment of Waldenström's Macroglobulinemia by PlasmapheresisA CASE OF ANÆMIA ASSOCIATED WITH MACROGLOBULINÆMIAMacroglobulins and High Molecular Weight AntibodiesThe Gamma Globulins and Their Clinical Significance 1 May 1958Volume 48, Issue 5Page: 1055-1069KeywordsCryptococcus neoformansGlobulinsHemolytic anemiaHemorrhageHospital medicineHyperglobulinemiaMultiple myelomaProteinsThrombosisUltracentrifugation Issue Published: 1 May 1958 PDF DownloadLoading ...