tbuckley/cabot-search huggingface dataset:
Pulsatile Myocardial Tubes Fabricated With Cell Sheet Engineering
Authors: Hidekazu Sekine, Tatsuya Shimizu, Joseph Yang, Eiji Kobayashi, Teruo Okano
Journal: Circulation (2006)

Tissue engineering approaches involving the direct transplantation of cardiac patches have received significant attention as alternative methods for the treatment of damaged hearts. In contrast, we used cardiomyocyte sheets harvested from temperature-responsive culture dishes to create pulsatile myocardial tubes and examined their in vivo function and survival.Neonatal rat cardiomyocyte sheets were sequentially wrapped around a resected adult rat thoracic aorta and transplanted in place of the abdominal aorta of athymic rats (n=17). Four weeks after transplantation, the myocardial tubes demonstrated spontaneous and synchronous pulsations independent of the host heartbeat. Independent graft pressures with a magnitude of 5.9+/-1.7 mm Hg due to their independent pulsations were also observed (n=4). Additionally, histological examination and transmission electron microscopy indicated that the beating tubes were composed of cardiac tissues that resemble the native heart. Finally, when myocardial tubes used for aortic replacement were compared with grafts implanted in the abdominal cavity (n=7), we observed significantly increased tissue thickness, as well as expression of brain natriuretic peptide, myosin heavy chain-alpha, and myosin heavy chain-beta.Functional myocardial tubes that have the potential for circulatory support can be created with cell sheet engineering. These results also suggest that pulsation due to host blood flow within the lumen of the myocardial tubes has a profound effect on stimulating cardiomyocyte hypertrophy and growth. These results demonstrate a novel approach for the future development of engineered cardiac tissues with the ability for independent cardiac assistance.
Hepatic and intestinal cytochrome P450 3A activity in cirrhosis: Effects of transjugular intrahepatic portosystemic shunts
Authors: Naga Chalasani, Christopher J. Gorski, Nilesh H. Patel, Stephen D. Hall, Raymond E. Galinsky
Journal: Hepatology (2001)

Transjugular intrahepatic portosystemic shunt (TIPS) is performed to treat some complications of cirrhosis. This study investigated the effects of cirrhosis and TIPS on intestinal and hepatic cytochrome P450 3A (CYP3A) activity. Nine volunteers were cirrhotic patients with TIPS, 9 were cirrhotic controls (matched for sex, age, etiology, and Child-Pugh class), and 9 were sex- and age-matched healthy volunteers. Simultaneous doses of midazolam were given intravenously (0.05 mg/kg) and orally (3 mg of [ 15 N 3 ]midazolam). Peripheral and portal venous blood samples were assayed for midazolam and [ 15 N 3 ]midazolam. The systemic clearance of midazolam was significantly greater ( P &lt; .05) in healthy volunteers (0.42 ± 0.10 L · h −1 · kg −1 ) compared with cirrhotic controls (0.20 ± 0.05) and with cirrhotic patients with TIPS (0.21 ± 0.09). Hepatic availability followed the same trend. The bioavailability of midazolam was significantly higher ( P &lt; .05) in cirrhotic patients with TIPS (0.76 ± 0.20) compared with cirrhotic controls (0.27 ± 0.14) and with healthy volunteers (0.30 ± 0.10). The intestinal availability was significantly greater ( P &lt; .05) in cirrhotic patients with TIPS (0.83 ± 0.17) compared with cirrhotic controls (0.32 ± 0.16) and with healthy volunteers (0.42±0.15). As expected, hepatic CYP3A activity was reduced in cirrhosis. However, in cirrhotic patients with TIPS, there was a marked loss in first-pass metabolism of midazolam as a result of diminished intestinal CYP3A activity.
Atrioventricular Conduction Block Caused by Phenylpropanolamine
Authors: Olga F. Woo
Journal: JAMA (1985)

<h3>To the Editor.—</h3> In a recent review of the toxicity of over-the-counter stimulants, Pentel<sup>1</sup>noted hypertension, myocarditis, and ventricular arrhythmias following the use of phenylpropanolamine hydrochloride. We report two patients with increased blood pressure and bradycardia with atrioventricular block of the Wenckebach type following the ingestion of proprietary products containing phenylpropanolamine. <h3>Report of Cases.—Case 1.—</h3> A 13-year-old girl with no history of cardiovascular disease ingested 13 Triaminicin capsules (phenylpropanolamine hydrochloride, 25 mg; chlorpheniramine maleate, 2 mg; aspirin, 450 mg; and caffeine, 30 mg). On admission to the emergency department 1 1/4 hours after the ingestion, she was alert but complained of being light-headed. Her blood pressure was 130/100 mm Hg; pulse rate, 58 beats per minute and irregular; and temperature, 36.3 °C (97.4 °F). Physical examination findings were remarkable only for slight epigastric tenderness and bradycardia. The serum salicylate concentration two hours after ingestion was 17.4 mg/dL.
Traumatic Partial Lobectomy from Gunshot Wound
Authors: Edgar M. Holmes
Journal: New England Journal of Medicine (1948)

IN THE following case the patient received a head injury similar to that in the famous crowbar-skull case, which has been written up in the past and the skull of which is on exhibition at the Harvard Medical School Museum. In that case, a miner while tamping a hole in the ground filled with blasting powder accidentally ignited the blast, which created a projectile of the tamping crowbar. The projectile entered the head just lateral to the angle of the left ramus of the mandible, traveling medially and superiorly to find its exit near the midline, where the parietal and . . .
STUDIES ON ANTIBODY PRODUCTION
Authors: William T. Butler, Albert H. Coons
Journal: The Journal of Experimental Medicine (1964)

The effect of drugs upon the primary and the secondary antibody response to diphtheria toxoid in mice was studied using an experimental system previously described. Triethylenethiophosphoramide (thio-TEPA), chloramphenicol, 6-mercaptopurine, 8-azaguanine, and versenate were found to inhibit, partially or completely,"priming" for the secondary response. Thio-TEPA, chloramphenicol, and 6-mercaptopurine, in doses exceeding those effective in inhibiting priming, did not cause alteration of the secondary response when given only during the secondary response. However, when chloramphenicol and amethopterin were given for 5 days prior to and at least 5 days after the second antigen injection, slight suppression of peak secondary titers occurred. Therefore, drug dosages effective in suppressing priming had less effect on the secondary response. It thus appears that there is a real difference between "priming" and the induction of antibody synthesis.
741 Safety, tolerability and antiviral activity of pradefovir mesylate in patients with chronic hepatitis B virus infection: 48-week analysis of a phase 2 study
Authors: K.S. Lee, S.G. Lim, W.L. Chuang, S.G. Hwang, M. Cho, M.Y. Lai, Y.C. Chao, T.T. Chang, K.H. Han, C.M. Lee, S.H. Um, J.E. Yeon, S.S. Yang, E.K. Teo, C.Y. Peng, H.H. Lin, T.I. Huo, T. Nguyen, T.Y. Chen, K.Q. Hu, Y. Xu, J.Z. Sullivan-Bólyai, K.S. Lee
Journal: Journal of Hepatology (2006)
VACCINE TREATMENT OF SPLENOMEGALY IN CHRONIC MALARIA
Authors: R. E. Ingram-Johnson
Journal: BMJ (1925)

gradually disappeared.He remained in hospital for a month, and miade an excellent recovery.When I saw him recently he was quite well, and his hearing was fair; he had had no further giddi- ness.The post-aural wound soon healed, and although there was a slight discharge from the ear for a month or two it is now dry.
Myocardial Enzyme Levels and Mortality After Coronary Artery Bypass Graft Surgery
Authors: Khaled D. Algarni
Journal: JAMA (2011)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Survival of Patients With Biventricular Devices After Device Infection, Extraction, and Reimplantation
Authors: John Rickard, Khaldoun Tarakji, Alan Cheng, David Spragg, Daniel J. Cantillon, David O. Martin, Bryan Baranowski, Steven M. Gordon, W.H. Wilson Tang, Mohammed Kanj, Oussama Wazni, Bruce L. Wilkoff
Journal: JACC Heart Failure (2013)
Cardiac Anesthesia, vol 2: Cardiovascular Pharmacology
Authors: Ronald M. Meyer
Journal: JAMA (1984)

In the five years since its appearance, the first volume of<i>Cardiac Anesthesia</i>has become a standard text, in many ways the nucleus around which the specialty of cardiac anesthesia has formed. Now, the same editor has brought out a second volume, subtitled<i>Cardiovascular Pharmacology</i>. The new book is not an update of the 1979 edition, which was organized according to states of cardiac disease and methods of circulatory support. It is instead a review of the applications of modern drugs to the perioperative care of patients with cardiovascular diseases, organized around classes of drugs. I believe that this new volume will achieve its stated goal, to "further improve anesthesia care for all patients with cardiac disease." There is much about this book that is current and interesting, and a bit that could have been left out without compromising the quality. The book has seven sections and 28 chapters, each
Reset Osmostat in Hyponatremia
Authors: MICHAEL F. MICHELIS
Journal: Annals of Internal Medicine (1976)

Comments1 September 1976Reset Osmostat in HyponatremiaMICHAEL F. MICHELIS, M.D., F.A.C.P.MICHAEL F. MICHELIS, M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-85-3-403_2 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: The paper by DeFronzo, Goldberg, and Agus, "Normal Diluting Capacity in Hyponatremic Patients" (Ann Intern Med 84:538-542, 1976), proposes three criteria for the diagnosis of reset osmostat in patients with hyponatremia: a normal response to water loading, concentration of the urine when serum tonicity is raised above the reset level, and failure to correct the hyponatremia with salt loading.I wish to take issue with the last of these proposed criteria. One of the points emphasized in a recent report (1), cited by DeFronzo and associates, was that reset phenomena could be demonstrated in a patient with...Reference Reference1. MICHELISFUSCOBRADGON MRR: Reset of osmore-ceptors in association with normovolemic hyponatremia. Am J Med Sci 267:267-273, 1974 CrossrefMedlineGoogle Scholar1. DUNNBRENNANNELSON FTA: The role of blood osmolality and volume in regulating vasopressin secretion in the rat. J Clin Invest 52:3212-3219, 1973 CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Nephrology Section Department of Medicine Lenox Hill Hospital New York, NY 10021 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 September 1976Volume 85, Issue 3Page: 403-404KeywordsAttentionHyponatremiaSaltsUrine Issue Published: 1 September 1976 PDF DownloadLoading ...
Merlin isoform 2 in neurofibromatosis type 2–associated polyneuropathy
Authors: Alexander Schulz, Stephan L Baader, Michiko Niwa-Kawakita, Marie Juliane Jung, Reinhard Bauer, Cynthia Garcia, Ansgar Zoch, Stephan Schacke, Christian Hagel, Victor-Felix Mautner, C Oliver Hanemann, Xin-Peng Dun, David B Parkinson, Joachim Weis, J Michael Schröder, David H Gutmann, Marco Giovannini, Helen Morrison
Journal: Nature Neuroscience (2013)
A BONE CLIP FOR THE OPERATIVE TREATMENT OF FRACTURES: End Results in the Case of Growing Femurs
Authors: J. E. Adams
Journal: BMJ (1922)

recelit mloniltlhs he had been carried off the Rugby football field owing to aln attack of paini in the left loin wheni collared, and even wheni dancing he was sometimes obliged to retire witi similar symptoms.-Atexaminiationi the right kidnievwas palpable anid enilarged, the left kidney ten(der oni palpationi.MJicturition was not quite normal, the patient being obliged to pass urine onice during the night.The trine was clear and containied iho pus, but a streptococcus was grovn on culture.Temiiperattire 99.Cystoscopy slrowed the bladder wall to be healthy, with slighit iI)jection of the mucous membranie around the left ureteric orifice.Pyelography demonstrated lhypertropliy of the right kidnley and lisorganization of the left kidney. (See Figs. 5 and 6.)In this case the injecticii fluid used was a 30 per cent.solution of sodium iodide.A rise of temperature and iicrease of pain in the left loin
Female genital mutilation
Authors: J A Black, G D Debelle
Journal: BMJ (1996)

Ratio ofwaist circumference to height may be better indicator of need for weight management EDITOR,-The metabolic consequences of obesity relate to the accumulation of visceral fat, which is seemingly reflected by the waist circumference.We add our support to the proposal that sex specific action levels based on the waist circum- ference could be used as a measure for managing weight.'2We also suggest that the ratio of waist circumference to height may be a superior measure for women as well as men.3We took data from the 1992 health survey for England.4For each person (1411 men and 1481 women aged 30-74) anthropometric measurements and ratios were compared with the logarithm of his or her risk of coronary heart disease, calculated from his or her sex, age, blood pressure, cholesterol concentration, and smoking and diabetic status.'The highest coefficient of correlation with risk of coronary heart disease was with the ratio of waist circumference to height for men (r=0-38) and women (r=0-31) (table 1).Stepwise regression
Release clinicians from the four walls of the hospital or practice
Authors: S. Chok
Journal: BMJ (2015)

I have been a GP in Tower Hamlets, east London, since 1998, and have just resigned from my practice. The job I was trained to do and would like to do (to spend most of my time treating patients like the frail elderly people who need our skills the most) does not exist. Instead I, like many colleagues, find myself doing 12 hour days, half of which are spent on administrative tasks.

If I ran the NHS I would make changes to release clinicians from …
Doctors and patients complain about severe health restrictions on driving licences
Authors: A. Iriberri
Journal: BMJ (2012)

Spanish doctors are angry that rules governing the renewal of driving licences that exclude certain groups of patients have been drawn up without their being consulted. 

Although the law has been in place since June 2009, people undergoing chemotherapy for cancer and those with diabetes, with certain heart conditions, or who have had a kidney transplant are only just finding out that their health is an impediment to driving. 

Ignacio Fernandez Lozano, a spokesman for the Spanish Society of Cardiology, criticised the government for issuing the law without consulting medical experts. 

“If you want my opinion, the problem is …
Pelvic mass in a 12-year-old girl
Authors: B. Felson
Journal: JAMA (1977)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Presence of Autoantibodies to Carbonic Anhidrase II and Lactoferrin in Type 1 Diabetes
Authors: Takao Taniguchi, Kazuichi Okazaki, Motozumi Okamoto, Shuji Seko, Kazushige Uchida, Yutaka Seino
Journal: Diabetes Care (2001)

Decreased insulin sensitivity in offspring whose parents
Investigation of genesis of gallop sounds in dogs by quantitative phonocardiography and digital frequency analysis.
Authors: A E Aubert, B G Denys, F Meno, P S Reddy
Journal: Circulation (1985)

Several investigators have noted external gallop sounds to be of higher amplitude than their corresponding internal sounds (S3 and S4). In this study we hoped to determine if S3 and S4 are transmitted in the same manner as S1. In 11 closed-chest dogs, external (apical) and left ventricular pressures and sounds were recorded simultaneously with transducers with identical sensitivity and frequency responses. Volume and pressure overload and positive and negative inotropic drugs were used to generate gallop sounds. Recordings were made in the control state and after the various interventions. S3 and S4 were recorded in 17 experiments each. The amplitude of the external S1 was uniformly higher than that of internal S1 and internal gallop sounds were inconspicuous. With use of Fourier transforms, the gain function was determined by comparing internal to external S1. By inverse transform, the amplitude of the internal gallop sounds was predicted from external sounds. The internal sounds of significant amplitude were predicted in many instances, but the actual recordings showed no conspicuous sounds. The absence of internal gallop sounds of expected amplitude as calculated from the external gallop sounds and the gain function derived from the comparison of internal and external S1 make it very unlikely that external gallop sounds are derived from internal sounds.
Sun protection with hats
Authors: B.L. DIFFEY, J. CHEESEMAN
Journal: British Journal of Dermatology (1992)

Summary The degree of sun protection provided by various styles of hat at different anatomical sites on the head was measured using model headforms and ultraviolet-sensitive film badges. It was found that hats with a small brim, such as the flat cap favoured by elderly male photosensitive patients, provided negligible protection at all sites apart from the vertex and forehead. Peaked baseball-style caps offer good protection to the nose but are relatively ineffective at other sites on the face. Hats with a wide (>7.5 cm) brim are necessary in order to provide reasonable protection factors (>3) around the nose and cheeks.
Mucocutaneous histoplasmosis in AIDS
Authors: F.J. SOUZA FILHO, M. LOPES, O.P. ALMEIDA, C. SCULLY
Journal: British Journal of Dermatology (1995)

A 36-year-old man, who was an intravenous drug abuser, developed thoracic herpes zoster, paronychia, oral candidosis, necrotizing gingivitis and bilateral parotid salivary gland swelling. Granulomatous oral lesions and ulceration on the nose were shown to be due to disseminated histoplasmosis.
German health policy is likely to become more pro-doctor, expert predicts
Authors: N. Stafford
Journal: BMJ (2009)

In the wake of Germany’s federal parliamentary election last month, healthcare policy has emerged as one of the most contentious issues facing Chancellor Angela Merkel as she begins talks with other party leaders to form a coalition government for the next four years.

Coalition talks began on 5 October in Berlin and are expected to last several weeks. Although the detail of the final healthcare package is still in question, it seems certain that the new government will be much more supportive of the wishes of doctors and private health insurers than were recent governments, said Heinz Rothgang, director of healthcare economics, policy, and research at the University of Bremen’s Centre for Social Politics.

This new support for doctors will come mainly as a result of the return to government of the small pro-business Free Democratic Party (FDP), which has been …
Gastric Hyalinization as a Possible Consequence of Corrosive Injury
Authors: A. Kazsuba, Á. Vitéz, J. Gáll, L. Máthé, É. Ludmány, G. Krasznai
Journal: Endoscopy (2000)

We report a case of gastric obstruction due to hyalinization of the antrum. The endoscopic appearance of the lesion was suggestive of Crohn's disease or gastric neoplasm. Biopsy showed pseudopolypous gastritis with ulceration and fibroid granulation. Surgery was carried out to relieve the obstruction. Examination of the resected specimen showed massive hyalinization of all layers of the antral wall with circular collagenous infiltration and a normal duodenal bulb. The question of hyaloid gastritis as a unique entity is raised. Subsequently, information from the patient revealed the cause: voluntary acid ingestion causing corrosive injury.
Treatment of Mild Hypertension
Authors: Henry R. Black
Journal: JAMA (1993)

Though the data from the most recently completed National Health and Nutrition Examination Survey III (1988 through 1991) has enabled us to revise downward (from 58 million to 50 million) earlier estimates of how many Americans have hypertension (a systolic blood pressure of 140 mm Hg or greater and/or a diastolic blood pressure of 90 mm Hg or greater, or taking antihypertensive medication), high blood pressure remains the most common reason that we seek medical attention in this country.<sup>1</sup>The overwhelming majority of these patients, perhaps as many as 60%, have what was called "mild" hypertension and is now more appropriately designated as stage 1 hypertension (properly measured and confirmed systolic blood pressure of 140 to 159mm Hg or diastolic blood pressure of 90 to 99mm Hg).<sup>2</sup>There is little question that both men and women with these seemingly modest elevations of blood pressure are at substantially greater