tbuckley/cabot-search huggingface dataset:
Awakenings
Authors: Charlotte Allan
Journal: BMJ (2007)

In 1969 levodopa (L-dopa) was hailed as a miracle drug that would cure parkinsonism. Sacks's book Awakenings is a series of extraordinary case reports describing how patients trapped by parkinsonism were re-awakened by levodopa after decades of stupor and inertia.

After the first world war, an epidemic of encephalitis lethargica started in Vienna and spread across the world. Many of those who survived developed a range of postencephalitic syndromes. Oliver Sacks worked at Mount Carmel, an institution outside New York, which had 80 patients with intractable, post-encephalitic parkinsonian syndrome. It affected all aspects of behaviour and trapped patients within themselves, often for decades. For patients such as Miriam H, who developed parkinsonism at the age of 12, levodopa was a miracle drug that released her from physical immobility at the age of 49.

Levodopa had dramatically different effects between patients and within the same patient. Despite being titrated slowly, the effects of levodopa were unpredictable and random. Leonard L, when started on levodopa, returned to a happiness he “had not felt for thirty years.” Yet six weeks later he developed exaggerated sensitivity to the drug and even with tiny doses had uncontrollable side effects. Even when the drug was prescribed carefully, the complexity of the brain made taking it anything but straightforward, and for some patients it was a nightmare rather than a fairytale awakening. 

For many patients psychological, environmental, and emotional factors seemed to have a profound effect on the efficacy of levodopa. Miron V initially had an excellent response, but then became violently unstable. However, when he resumed work at a cobbler's workshop, his mood stabilised; he became cheerful and continued to be well while taking levodopa. Even when the responses to the drug were positive, patients were not always able to cope with the consequences. Rose R was struck by sleeping sickness at the age of 21 and awoke in 1969 to find her world of 1926 had vanished. She remained rooted in the 1920s and, as if the time gap was beyond her comprehension, stopped responding to levodopa. 

Sacks talks with humanity and a deep sense of concern about all his patients. He makes clear that treating them required far more than giving them a new drug. Although levodopa was not always successful, the long term relationship Sacks had with his patients was crucial for them and their families. Awakenings is an important reminder that healing is a complex art and that the notion that one pill can cure disease remains a fantasy.

Awakenings captures readers' imagination with the fairytale notion of returning to life after decades blighted by parkinsonism. It has not only been published as a book but has also inspired a radio play, a stage play, and a film. Although there were many problems with levodopa, it leaves us wondering what seemingly impossible conditions may yet find a cure. And it inspires us to remember that despite life changing medical advances, the art of healing remains of fundamental importance.
Maintenance Therapy With Lenalidomide Significantly Improved Survival Of Yong Newly Diagnosed Multiple Myeloma Patients
Authors: Francesca Gay, Federica Cavallo, Tommaso Caravita, Maide Cavalli, Arnon Nagler, Vittorio Montefusco, Enrico Maria Pogliani, Silvia Buttignol, Elena Zamagni, Carmela Palladino, Magda Marcatti, Pellegrino Musto, Lucio Catalano, Anna Baraldi, Angelo Michele Carella, Anna Maria Cafro, Agostina Siniscalchi, Claudia Crippa, Letizia Maria Vallone, Giovannino Ciccone, Dina Ben Yehuda, Francesco Di Raimondo, Izhar Hardan, Mario Boccadoro, Antonio Palumbo
Journal: Blood (2013)
More on platelet-rich plasma injections in acute muscle injury.
Authors: Eduardo Anitua, Mikel Sánchez, Sabino Padilla
Journal: New England Journal of Medicine (2014)

1. Verso M, Agnelli G, Barni S, Gasparini G, LaBianca R. A modified Khorana risk assessment score for venous thromboembolism in cancer patients receiving chemotherapy: the PROTECHT score. Intern Emerg Med 2012;7:291-2. 2. Moore RA, Adel N, Riedel E, et al. High incidence of thromboembolic events in patients treated with cisplatin-based chemotherapy: a large retrospective analysis. J Clin Oncol 2011;29: 3466-73. 3. Ay C, Dunkler D, Marosi C, et al. Prediction of venous thromboembolism in cancer patients. Blood 2010;116:5377-82. 4. Mandybur TI. Intracranial hemorrhage caused by metastatic tumors. Neurology 1977;27:650-5. 5. Perry JR, Julian JA, Laperriere NJ, et al. PRODIGE: a randomized placebo-controlled trial of dalteparin low-molecular-weight heparin thromboprophylaxis in patients with newly diagnosed malignant glioma. J Thromb Haemost 2010;8:1959-65.
Abstract 13453: Comparison of Right Ventricular Longitudinal Strain Imaging, Tricuspid Annular Plane Systolic Excursion, and Cardiac Biomarkers for Early Diagnosis of Cardiac Involvement and Risk Stratification in AL Amyloidosis: a Five Year Cohort Study
Authors: Diego Bellavia, Patricia Pellikka, Angela Dispenzieri, Christopher Scott, Hector Villarraga, Haydar Saleh, Marcello Traina, Robert Nardino, Jae Oh, Fletcher A Miller
Journal: Circulation (2010)

Objectives:  The aim was to determine the role of assessing right ventricular (RV) function, using standard echocardiography and Doppler myocardial imaging (DMI), in the early diagnosis of cardiac amyloidosis (CA) and in prediction of mortality.   Methods:  A total of 249 patients with AL amyloidosis were categorized on the basis of left ventricular thickness and E9 velocity, and compared to 38 age- and sex-matched controls. Standard echocardiographic parameters of RV function were assessed, and longitudinal systolic myocardial velocity, strain rate (sSR), and strain (sS) were determined for the basal and middle RV free wall segments. Patients were followed for the endpoint of mortality.   Results:  RV tricuspid annular plane systolic excursion (TAPSE), and all DMI measurements were lower in AL-normal-echo group than in controls. A bivariate model including strain of the basal segment of the RV free wall and TAPSE was the best for distinguishing AL-normal-echo patients from controls (ROC area: 0.81, positive predictive value, 75%; negative predictive value, 64%). During a median follow-up of 53 months, 126 patients died (51%). Male gender (HR 2.2 P 0.005, (log) BNP levels (HR 1.4 P 0.003), Troponin T levels (HR 1.6 P 0.01), pleural effusion (HR 3.6 p    Conclusions:  DMI measures of RV are useful to identify early impairment of cardiac function or to stratify risk of death in patients with AL amyloidosis. Further studies with longer follow-up are warranted to confirm these results.
Abstract 14581: Mortality Risk of Coronary Artery Disease in a Propensity Score-Matched Cohort of Diabetic and Non-Diabetic Individuals Undergoing 64-Detector Row Coronary CT Angiography: Results from 17,241 Patients in the Prospective Multinational CONFIRM Registry (Coronary CT Angiography Evaluation for Clinical Outcomes: An International Multicenter Registry)
Authors: James K Min, Allison Dunning, Stephen Achenbach, Mouaz Al-Mallah, Daniel S Berman, Matthew J Budoff, Tracy Q Calllister, Hyuk-Jae Chang, Victor Cheng, Benjamin Chow, Augustin Delago, Martin Hadamitzky, Joerg Hausleiter, Ronald P Karlsberg, Philipp Kaufmann, Fay Y Lin, Khurram Nasir, Leslee J Shaw
Journal: Circulation (2010)

Background: Diabetes mellitus (DM) is considered a coronary artery disease (CAD_ equivalent, and individuals with DM experience higher rates of CAD mortality. The incremental risk of mortality amon...
Abstract MP025: Physical Activity and Risk of Coronary Heart Disease in Young Women
Authors: Andrea K Chomistek, Kenneth J Mukamal, A. H Eliassen, Eric B Rimm
Journal: Circulation (2012)

Background: The majority of studies on the association between physical activity and coronary heart disease (CHD) risk have been conducted in middle-aged and older populations. Although physical activity has been shown to lower risk of CHD in women by approximately 30%, evidence for the benefits of exercise for CHD in young women is very limited. Methods and Results: We conducted a prospective cohort study among 114 054 women, 25–42 years of age at baseline, enrolled in the Nurses’ Health Study II and followed from 1989 to 2009. Leisure-time physical activity was assessed at baseline and during follow-up through a series of questions on the specific type of activity and the average time per week spent on the activity over the previous year. Additionally, at baseline, women were asked the number of months per year they participated in strenuous exercise or sports during high school and ages 18–22. During 20 years of follow-up, we documented 518 new cases of non-fatal MI and fatal CHD. After adjusting for age and other cardiovascular risk factors, the rate ratios (RR) (95% confidence intervals [CI]) corresponding to 0, 0.1 – 3.5, 3.6 – 8.8, 8.9 – 21.0, and &gt; 21 MET-hours/week of physical activity were 1.0, 0.93 (0.71, 1.21), 0.73 (0.56, 0.95), 0.67 (0.52, 0.88), and 0.63 (0.49, 0.83) (p for trend = 0.001). There was no evidence of effect modification by age or body mass index. Specifically in women less than 50 years of age, the corresponding RR were 1.0, 0.97 (0.70, 1.35), 0.75 (0.53, 1.04), 0.69 (0.50, 0.96), and 0.63 (0.45, 0.88) (p for trend = 0.008). Brisk walking alone was also associated with significant reductions in CHD risk. In contrast to physical activity during adulthood, frequency of participation in strenuous activity in high school or during ages 18–22 was not associated with risk of CHD when adjusted for current physical activity. Conclusions: These prospective data suggest that physical activity is associated with substantial risk reductions in the incidence of coronary heart disease in young women.
发热-胸痛-呼吸困难
Authors: 吴东, 黄晓明, 王玉
Journal: BMJ (2009)

患者男，57岁，因发热6d于2008年12月30日就诊。起病前1周工作劳累后着凉，发热，体温最高38．5℃，伴畏寒，咽痛，流涕。自服头孢氨苄青霉素无效，体温升高至40．1℃，咳嗽，有少量黄痰，左胸季肋部针刺样疼痛，深吸气时加重。患者在外企工作，较劳累。既往体健，无烟酒嗜好，否认慢性阻塞性肺疾病，否认糖尿病、慢性心肾疾病、恶性肿瘤、血液病，否认长期服用任何药物。家中未养宠物。
哮喘儿童持续吸入糖皮质激素前后血清骨碱性磷酸酶、甲状旁腺素和25-羟维生素D3水平的变化
Authors: 郭茜, 周新龙, 尹丽明
Journal: BMJ (2007)

观察87例哮喘患儿吸入丙酸氟替卡松1年时间前后血清骨碱性磷酸酶(BALP)、甲状旁腺素、25-羟维生素D3的水平.治疗前患儿血清BALP、甲状旁腺素增高,25-羟维生素D3下降,与对照组差异无统计学意义;治疗前血清BALP不受病情程度影响,但吸入激素后明显下降,以轻、中度组为著,重度组虽开始出现增高,但到1年时迅速下降;随患儿病情加重,25-羟维生素D3水平继续下降,甲状旁腺素浓度虽高于正常但不随病情加重而升高,治疗后25-羟维生素D3水平增高的程度与病情程度亦相平行,甲状旁腺素下降。
Characterization of Stromal Progenitor Cells Enriched by Flow Cytometry
Authors: Ron Zohar, Jaro Sodek, Christopher A.G. McCulloch
Journal: Blood (1997)

Abstract The progenitors for cells of bone, cartilage, fat, and muscle are thought to be derived from mesenchymal stem cells but despite extensive study of stromal cell differentiation, neither mesenchymal stem cells or the more committed, tissue-specific progenitors have been well-characterized. In this study we used flow cytometry to isolate from fetal rat periosteum a population of small, slowly cycling cells with low cytoplasmic granularity (S cells) that display stem cell characteristics. On plating, S cells exhibited a 90% higher labeling index with [3H]-thymidine compared to unsorted cells and when grown in culture generated cartilage, adipocyte, and smooth muscle phenotypes, in addition to bone. Only the S-cell population showed extensive self-renewal of cells with osteogenic potential. Electron microscopy showed that S cells have high nuclear:cytoplasmic ratios with large condensed nuclei and a paucity of cytoplasmic organelles. Freshly sorted suspensions of immunocytochemically stained S cells did not express differentiation-associated markers such as type I, II, and III collagens, alkaline phosphatase, or osteopontin. However, after attachment, S cells became immunopositive for collagens I, II, III, osteopontin, and also for the cell surface receptor CD44, which mediates cell attachment to hyaluronan and osteopontin. These studies show that viable osteogenic precursor cells with the stem cell characteristics of self-renewal, high proliferative capacity, and multipotentiality can be enriched from heterogeneous stromal cell populations with simple flow cytometric methods. These cells may be useful for regeneration of stromal tissues.
Abstract 14518: Non-Fluoroscopic Catheter Ablation of Cardiac Arrhythmias in Adults Using Electroanatomic Mapping and Intracardiac Echocardiography
Authors: Mansour Razminia, Marian F Manankil, Oliver D'Silva, Christian S Lopez, Carlos Arrieta, Terry A Zheutlin, Saba Khan, Paula L Eryazici, Theodore Wang, Marianne Turner, Richard F Kehoe
Journal: Circulation (2011)

Background. Catheter ablation of arrhythmias is traditionally performed under fluoroscopic guidance exposing patients and medical staff to radiation hazard. Additionally, dependence on fluoroscopy ...
Lesson of the Week: Cholesterol emboli may mimic systemic vasculitis
Authors: D S Peat, P. W Mathieson
Journal: BMJ (1996)

The clinical syndrome resulting from multiple cholesterol emboli is a great mimic. Many organs may be affected: typical features include a purpuric rash, livedo reticularis, myalgia, and acute renal failure. Cholesterol emboli may complicate cardiac catheterisation or arteriography, or they may occur spontaneously, even in patients without previously known vascular disease.

Multiple cholesterol emboli may cause symptoms, signs, and laboratory abnormalities indistinguishable from those of primary systemic vasculitis

We report on a 73 year old man with acute renal failure in whom clinical signs and laboratory tests suggested a pulmonary-renal syndrome caused by systemic vasculitis but who turned out to have cholesterol emboli. The treatment and prognosis of the two conditions are radically different.

A 73 year old man was admitted to our hospital with rapidly deteriorating renal function. In the referring hospital chest pain and hypertension had been treated with nifedipine and aspirin. Initial plasma urea concentration was 17 mmol/l and plasma creatinine concentration 222 μmol/l. Over the next two weeks he became oliguric and plasma biochemical values deteriorated.

On transfer he was unwell with severe dyspnoea at rest, repeated haemoptysis, and profound oliguria. Chest radiography showed bilateral alveolar shadowing. Blood gases while breathing air showed a partial pressure of oxygen (Po2) of 8.6 kPa, partial pressure of carbon dioxide (Pco2) of 2.3 kPa, and hydrogen ion of …
P0457 : Graphene quantum dots attenuate concanavalin A-induced hepatitis
Authors: V. Volarevic, V. Paunovic, Z. Markovic, B. Simovic Markovic, M. Misirkic Marjanovic, B. Todorovic Markovic, S. Bojic, L. Vucicevic, S. Jovanovic, N. Arsenijevic, I. Holclajtner-Antunovic, M. Milosavljevic, M. Dramicanin, T. Kravic Stevovic, D. Ciric, M.L. Lukic, V. Trajkovic
Journal: Journal of Hepatology (2015)
Abstract 1824: Pilsicainide, a Pure Sodium Channel Blocker, Enhances the Arrhythmogenic Endocardial Substrate in Brugada Syndrome.
Authors: Koji Fukuda, Koji Kumagai, Yuji Wakayama, Yoshinao Sugai, Masanori Hirose, Nobuhiro Yamaguchi, Hiroaki Shimokawa
Journal: Circulation (2007)

Background: Epicardial electrical abnormalities, especially those in right ventricular (RV) outflow tract, are likely to be involved in the arrhythmogenic substrates in Brugada syndrome (BS). Howev...
Abstract 4986: A Physiology-Based Mathematical Model of Coronary Heart Disease Accurately Predicts CHD Event Rates in Real Populations
Authors: Montiago LaBute, Julia Dziuba, George Waksman, Barbara Peskin
Journal: Circulation (2008)

The high societal burden of coronary heart disease (CHD) and prohibitive costs associated with clinical trials mandate the need for other methods to investigate new diagnostic protocols, disease management strategies and treatments. The Archimedes Model is a clinically detailed simulation model of human physiology, disease progression, and healthcare systems designed to support such investigations. The model has been validated against more than 50 of the most important clinical trials involving both primary and secondary prevention populations. The model includes emerging biomarkers and conventional CHD risk factors. Here we assess the accuracy of the model by simulating the evolution of CHD events in two primary prevention populations: the Atherosclerosis Risk In Communities (ARIC) and the Framingham Heart Study (FHS) prospective observational studies. Initial populations were created by matching the baseline information in FHS (N=4960) and ARIC (N=12800), and individual-level outcomes of incident and recurrent CHD events (non-fatal and fatal myocardial infarction) were tracked over time. These data were used to calculate Kaplan-Meier curves. Two-tailed p-values were derived from comparison of the simulated and actual survival curves using the log-rank test. P-values for incident (ARIC: p=0.349; FHS: p=0.811) and recurrent (ARIC: p=0.879; FHS: p=0.951) events indicate that there are no significant differences between the simulated and real populations. In conclusion, the Archimedes Model is capable of predicting both incident and recurrent CHD events with a high degree of accuracy in general populations, making it a valuable tool for healthcare applications. First myocardial infarctions (fatal and non-fatal). Dashed red lines are computed from study data. Solid blue lines are Archimedes Model simulation results.
A Novel β Globin Gene Mutation, Reported As An α Chain Hemoglobin Variant By High Performance Liquid Chromatography (HPLC) &amp; As Sickle Cell Trait On New Born Screening: A case Report
Authors: Kranthi Nandan Seelaboyina, Jennifer Alison Busse, Sandeep Malik, Thomas Moulton
Journal: Blood (2013)
Sequential Intensiﬁed Conditioning Followed By Tapering Of Prophylactic Immunosupressants and Donor Lymphocyte Infusions In Allogeneic Hematopoietic Stem Cell Transplantation For Refractory Leukemia
Authors: Qifa Liu, Li Xuan, Yu Zhang, Hongsheng Zhou, Fen Huang, Min Dai, Yonghua Li, Danian Nie, Na Xu, Xutao Guo, Dongjun Lin, Yang Xiao, Can Liu, Qianli Jiang, Jing Sun
Journal: Blood (2013)
Abstract 10219: The Prognostic Value of the Ratio of Eicosapentaenoic Acid to Arachidonic Acid in Patients with Acute Coronary Syndrome
Authors: Satoru Sakuragi, Kazuhiko Yamamoto
Journal: Circulation (2011)

Background: The ratio of eicosapentaenoic acid (EPA) to arachidonic acid (AA) is a predictor of cardiac event in patients with chronic coronary artery disease and favorite effect of intake of EPA o...
Hematopoiesis in Patients with Acquired Aplastic Anemia Is Supported By a Limited Number of CXCR4(-) Cells at the Common Myeloid Progenitor Level
Authors: Takamasa Katagiri, Atsuo Kasada, Kana Motomiya, Yoshitaka Zaimoku, An T. T. Dao, Hiroyuki Maruyama, Ken Ishiyama, Shigeki Ohtake, Atsushi Hirao, Shinji Nakao
Journal: Blood (2014)
Therapeutic Benefits and Safety of Carvedilol in the Treatment of Renal Hypertension
Authors: Masakazu Kohno, Tadanao Takeda, Masao Ishii, Takao Saruta, Yasushi Mizuno, Manabu Yoshimura, Shinichiro Kubo, Koshiro Fukiyama, Masatoshi Fujishima
Journal: Drugs (1988)
Abstract 2975: Severe Aortic Stenosis and Chronic Obstructive Pulmonary Disease: What is the Risk of Aortic Valve Replacement in the Modern Surgical Era?
Authors: Daniel B Spoon, Rick A Nishimura, Eric S Edell, Zhou Li, Thomas A Orszulak
Journal: Circulation (2009)

Background: Patients with aortic stenosis (AS) and chronic obstructive pulmonary disease (COPD) have been considered high risk for aortic valve replacement (AVR), which results in some patients bei...
Progenitor cell markers predict outcome of patients with hepatocellular carcinoma beyond Milan criteria undergoing liver transplantation
Authors: Oriana Miltiadous, Daniela Sia, Yujin Hoshida, Maria Isabel Fiel, Andrew N. Harrington, Swan N. Thung, Poh Seng Tan, Hui Dong, Kate Revill, Charissa Y. Chang, Sasan Roayaie, Thomas J. Byrne, Vincenzo Mazzaferro, Jorge Rakela, Sander Florman, Myron Schwartz, Josep M. Llovet
Journal: Journal of Hepatology (2015)
Note on the Influence of the Number of Litters upon the Incidence of Mammary Tumors in Mice
Authors: O. Mühlbock
Journal: JNCI Journal of the National Cancer Institute (1950)

Note on the Influence of the Number of Litters upon the Incidence of Mammary Tumors in Mice Get access O. Mühlbock O. Mühlbock Laboratory of the Antoni van Leeuwenhoekhuis, The Netherlands' Cancer Institute, Amsterdam, Holland Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 10, Issue 6, June 1950, Pages 1259–1262, https://doi.org/10.1093/jnci/10.6.1259 Published: 01 June 1950 Article history Received: 10 March 1950 Published: 01 June 1950
Abstract 4684: Differences in Baseline Features and Long Term Follow-Up Post-Transcatheter Closure in Patients with Secundum Atrial Septal Defect - A Cohort Study
Authors: Gerald Yong, Paul Khairy, Pierre de Guise, Reda Ibrahim
Journal: Circulation (2008)

Patients with atrial septal defects (ASD) may develop pulmonary arterial hypertension (PAH). We aimed to explore predictors of PAH and characterize the evolution of pulmonary arterial systolic pressures (PASP) after transcatheter ASD closure. A cohort study was performed on 215 consecutive patients who underwent attempted transcatheter ASD closure, of which 194 were successful. Patients were classified into 4 groups based on PAH severity derived from baseline echocardiographic PASP estimates: no PAH (&lt;40mmHg; Group I, n=107), mild PAH (40 –50mmHg; Group 2, n=62), moderate PAH (50 – 60mmHg; Group 3, n=27), and severe PAH (≥60mmHg; Group 4, n=19). Follow-up echocardiography was performed at a median of 10 months (IQR 3, 25 months). Independent predictors of moderate or severe baseline PAH were older age (OR 1.10 per year, p&lt;0.0001), larger ASD size (OR 1.13 per mm, p=0.0052), female gender (OR 3.9, p=0.0313) and moderate or severe tricuspid regurgitation (OR 3.6, p=0.0043). Post closure, baseline PAH severity was associated with a greater likelihood of a ≥5mmHg reduction in PASP (33.7%, 73.9%, 79.2%, 100.0%, in Groups 1 to 4, p &lt;0.0001) and larger reduction in PASP (median reduction 0, 8, 17, 22 mmHg in Groups 1 to 4, p&lt;0.0001). However, likelihood of normalization of PASP (&lt;40mmHg) was inversely correlated with baseline PAH severity (90.2%, 71.7%, 66.7%, 23.5% for Groups 1 to 4, p&lt;0.0001). Higher baseline PASP (OR 1.20 per mmHg, p&lt;0.0001), younger age (OR 0.97, p=0.0202), and smaller body surface area (OR 0.13 per m 2 , p=0.0210) independently predicted a ≥5mmHg reduction in PASP. Among patients with moderate or severe baseline PAH, normalization of PASP occurred in 48.8%, and was independently predicted by a lower baseline PASP (OR 0.91 per mmHg, p=0.0418) and absence of moderate or severe tricuspid regurgitation preceding ASD closure (OR 0.139, p=0.0420). In patients with ASD, severity of PAH is modulated by age, gender, defect size, and presence of moderate or severe tricuspid regurgitation. Patients with moderate or severe PAH benefit from a substantial reduction in PASP post-transcatheter ASD closure, but PASP remains elevated in a sizeable proportion of patients, warranting close long-term follow-up.
Abstract 14090: Difference of In-Stent Restenosis Pattern of Drug-Eluting Stent in Early and Late Phase Restenosis: Optical Coherence Tomography Analysis
Authors: Takenori Domei, Shoichi Kuramitsu, Makoto Hyodo, Yoshimitsu Soga, Takeshi Arita, Shinichi Shirai, Kenji Ando, Katsuhiro Kondo, Koyu Sakai, Hiroyoshi Yokoi, Masashi Iwabuchi, Masakiyo Nobuyoshi
Journal: Circulation (2011)

Objectives: Difference of restenosis patterns of drug eluting stent (DES-ISR) between in early and in late phase has not fully investigated. The aim of this study is to evaluate the characteristics...
Abstract 1123: Association Between Depression and Inflammation - Differences by Race: The META-Health Study
Authors: Alanna Morris, Liping Zhao, Yusuf Ahmed, Neli Stoyanova, Aurelian Bidulescu, Dorothy Coverson, Zhimin Chen, Gary Gibbons, Rebecca Din-Dzietham, Arshed Quyyumi, Viola Vaccarino
Journal: Circulation (2009)

Background: Depression is an independent risk factor for incident cardiovascular disease (CVD), and inflammation has been implicated as a possible mechanism. Little is known about whether depressio...