tbuckley/cabot-search huggingface dataset:
A Janus Kinase Inhibitor, JAB, Is an Interferon-γ–Inducible Gene and Confers Resistance to Interferons
Authors: Hiroshi Sakamoto, Hideo Yasukawa, Masaaki Masuhara, Shyu Tanimura, Atsuo Sasaki, Kentaro Yuge, Motoaki Ohtsubo, Akira Ohtsuka, Takasi Fujita, Tsunetaka Ohta, Yusuke Furukawa, Satsuki Iwase, Hisashi Yamada, Akihiko Yoshimura
Journal: Blood (1998)
Chromosomal Abnormalities and Their Relation to Disease
Authors: D H CARR
Journal: JAMA (1963)

When human chromosome anomalies were first described in 1959, it appeared that specific abnormalities might be correlated with specific syndromes. Mongolism and the D and E syndromes are examples of specific syndromes associated with the presence of an extra autosome. Klinefelter's syndrome may be associated with a variety of different sex chromosome anomalies including XXY, XXYY, XXXY and XXXXY. The lastnamed variant is the only one that frequently presents features distinguishing it from the others. An XO sex chromosome complex is found in many women with gonadal dysgenesis. However, a variety of mosaicisms have been described in association with this condition, including XO/XX, XO/XXX, XO/XX/XXX, XO/XY and XO/XYY. Extra X chromosomes in phenotypical females do not seem to impair fertility or be consistently associated with congenital anomalies. Two families are described in which chromosome anomalies were found, but the association with defects was irregular. In one family the abnormality involved one of the number 16 chromosomes and in the other it involved one of the small acrocentric chromosomes.
Abstract P1-15-13: Short term toxicity of intra-operative radiotherapy for patients with breast cancer treated at a single center
Authors: Ayelet Shai, Maoz Zur, Michelle Leviov, Arie Bitterman, Shiloni Eitan, Mariana Steiner
Journal: Cancer Research (2015)

Abstract Introduction: Intra-operative radiotherapy (IORT) is increasingly being used for the treatment of low risk breast cancer. In the randomized TARGIT trial, late toxicity was not different between patients treated with IORT and external beam radiotherapy. Early toxicity of IORT has not been fully characterized. Methods: IORT with one dose of 20 Gy using the Intrabeam© device has been offered as an alternative to standard treatment as part of a single center prospective single arm trial. Patients over 60 years with clinically node negative, &amp;lt; 2 cm invasive duct carcinomas were eligible. Patients aged 50-60 years, patients with tumors 2-3.5 cm and patients with invasive lobular carcinomas were treated with IORT if they were not candidates for standard treatment. For the present study information regarding complications occurring within the first year after surgery was analyzed. Patients treated between 2006 and 2012 were included in this analysis. Results: 393 patients were treated from 2006 – 2012. 4 were lost to follow up. Median age was 70 years (55-90) and median clinical tumor size was 1.2 cm (5-30). 102 patients (26.2%) had a complication. Infections were most frequent. Misdiagnosis of radiation dermatitis as infection in some cases cannot be excluded. Clinically meaningful seromas occurred in 10.2% of patient and 8.2% had a wound dehiscence, possibly related to rupture of pre-existing seromas. Table 1Complication typeN (%)N with grade 3 (%)N with grade 4 (%)median time to recovery (range)Infection42 (11)3 (3.3) 0.62 (0.1 - 3.8)Seroma40 (10.2) 13.2 (0.3-50)Wound dehiscence33 (8.5)2 (0.5) 5.8 (0.36-15.3)Bleeding11 (2.8)3 (0.8) Skin necrosis2 (0.5) 2 (0.5)3.88 (3.45-4)frequency, severity and time to recovery of acute complications of IORT. 18 patients (4.6%) had a grade 3 complication. 2 patients (0.5%) had grade 4 radiation induced skin necrosis of small size and both resolved within 4 months. All other complications resolved completely (table 1). Risk factors for complications in this cohort will also be presented. Conclusions: Intra-operative radiotherapy was associated with a relatively high rate of clinically meaningful seromas and wound dehiscence and rare small size skin necrosis. Most complications were mild – moderate. 5% of patients experienced grade 3 or 4 complications, and all resolved completely. Further study of the factors predisposing to severe complications is warranted. Citation Format: Ayelet Shai, Maoz Zur, Michelle Leviov, Arie Bitterman, Shiloni Eitan, Mariana Steiner. Short term toxicity of intra-operative radiotherapy for patients with breast cancer treated at a single center [abstract]. In: Proceedings of the Thirty-Seventh Annual CTRC-AACR San Antonio Breast Cancer Symposium: 2014 Dec 9-13; San Antonio, TX. Philadelphia (PA): AACR; Cancer Res 2015;75(9 Suppl):Abstract nr P1-15-13.
Prolonged protection of the new inhaled corticosteroid fluticasone furoate against AMP hyperresponsiveness in patients with asthma
Authors: M. Van Den Berge, B. Luijk, P. Bareille, N. Dallow, D. S. Postma, J. ‐W. J. Lammers
Journal: Allergy (2010)

Single-dose inhaled corticosteroids (ICS) induce direct anti-inflammatory effects in asthma thereby improving airway hyperresponsiveness (AHR). A novel enhanced-affinity ICS, fluticasone furoate (FF), demonstrated a prolonged duration of action in vitro. The aim of this study was to evaluate the efficacy and duration of action of a single dose of FF by studying protection against AHR to adenosine 5'-monophosphate (AMP) and effects on exhaled nitric oxide (eNO).A randomized, double-blind, placebo-controlled, 6-way crossover study (FFA10026) was performed in 24 patients with allergic asthma (mean age 32.8 years, FEV(1) ≥ 70% predicted and PC(20) AMP ≤ 50 mg/ml). Each subject received a single dose of FF 1000 μg, fluticasone proprionate (FP) 1000 μg, or placebo at 2 (FF only), 14 or 26 h prior to AMP challenge and eNO measurement.FF significantly improved PC(20) AMP compared to placebo, the difference in doubling concentrations being 2.18 (95% confidence interval: 1.13-3.23), 1.54 (0.48-2.59), and 1.30 (0.26-2.34) at 2, 14 and 26 h. FP improved PC(20) AMP significantly at 14 h compared to placebo, but not at the 26-hour time point, the difference in doubling concentrations being 1.72 (0.70-2.75) and 0.33 (-0.69-1.34). There was no significant effect on eNO after either FF or FP at all time points. FF was well tolerated and there were no serious adverse events.The new inhaled corticosteroid FF, but not FP, demonstrates prolonged protection up to 26 h against AHR to AMP in asthma patients.
High-level reconstitution of respiratory burst activity in a human X- linked chronic granulomatous disease (X-CGD) cell line and correction of murine X-CGD bone marrow cells by retroviral-mediated gene transfer of human gp91phox
Authors: C Ding, A Kume, H Bjorgvinsdottir, RG Hawley, N Pech, MC Dinauer
Journal: Blood (1996)
Paradise Now: picturing the genetic revolution
Authors: Janice Hopkins Tanne
Journal: BMJ (2000)

Exit Art Gallery, 2nd floor, 548 Broadway (between Prince and Spring Streets in SoHo), New York

Until 28 October 2000

Rating: ![Graphic][1] ![Graphic][2] ![Graphic][3] 

Boldly the handout proclaims: “We are at a threshold, witnesses to the moment when genetic research is rewriting the definition of life … Artists have claimed an important role in this ongoing exploration, creating images that literally give shape to abstract, complex concepts.”

Artists? It seems a strange idea, getting 39 artists to depict issues raised by biotechnology. It isn't, though. The show is educational and thought provoking. I think you'll enjoy it, and I'm sure your …

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First News of the Battle of Lexington
Authors: M. Therese Southgate
Journal: JAMA (2002)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Prediction of functional recovery of viable myocardium after delayed revascularization in postinfarction patients
Authors: Jean-Luc Monin, Jérôme Garot, Marielle Scherrer-Crosbie, Jean Rosso, Anne-Marie Duval-Moulin, Patrick Dupouy, Emmanuel Teiger, Alain Castaigne, Jean-Claude Cachin, Jean-Luc Dubois-Rande, Pascal Gueret
Journal: Journal of the American College of Cardiology (1999)
Blockade of eosinophil migration and airway hyperresponsiveness by cPLA2-inhibition
Authors: Shigeharu Myou, Hiroyuki Sano, Masaki Fujimura, Xiangdong Zhu, Kazuyoshi Kurashima, Toshiyuki Kita, Shinji Nakao, Akitaka Nonomura, Takanobu Shioya, Kwang Pyo Kim, Nilda M. Munoz, Wonhwa Cho, Alan R. Leff
Journal: Nature Immunology (2001)
Pharmacological management—oral treatment
Authors: Graeme P Currie, Daniel K C Lee, Brian J Lipworth
Journal: BMJ (2006)

Inhaled treatment forms the cornerstone of drug management of chronic obstructive pulmonary disease (COPD). However, some patients—especially those who are elderly, cognitively impaired, or with upper limb musculoskeletal problems—are unable to use inhaler devices successfully.

Theophylline is one of the oldest oral bronchodilators available for the treatment of COPD. It has a similar chemical structure to caffeine, which is also a bronchodilator in large amounts.



Additive effects of theophylline and the bronchodilator salmeterol on lung function in patients with COPD at day 1 and at 12 weeks after starting treatment



Theophylline is a non-selective phosphodiesterase inhibitor, and it causes an increase in the intracellular concentration of cyclic AMP in various cell types and organs (including the lung). Increased cyclic AMP concentrations are implicated in inhibition of inflammatory and immunomodulatory cells. One result is that phosphodiesterase inhibition causes smooth muscle relaxation and airway dilation.

View this table:

Adverse effects of theophylline



Other potentially beneficial mechanisms of action of theophylline in COPD have been suggested, including

### Clinical use of theophylline

Consider a long acting theophylline preparation in patients with advanced COPD, especially when symptoms persist despite the use of inhaled long acting bronchodilators or in patients unable to use inhaler devices. Studies have shown that theophylline generally …
St Sebastian Tended by St Irene
Authors: M. Therese Southgate
Journal: JAMA (2003)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Proteomic evaluation of mammary glands of rats prepubertally exposed to Bisphenol A
Authors: Nandini Raghuraman, Craig Rowell, Mark Carpenter, Coral A. Lamartiniere
Journal: Cancer Research (2006)

4463   Bisphenol A (BPA), is an industrial compound commonly used in the production of polycarbonate plastic, epoxy resins, and dental sealants. BPA has been shown to advance puberty and disrupt estrous cyclicity, identifying it as an endocrine disruptor. It has previously been reported that rats treated with BPA during the prepubertal period were susceptible to irregular estrous cycles demonstrating that endocrine disruption during this critical developmental period can result in permanent reproductive alterations. The goal of this research was to identify differentially expressed proteins in mammary glands of rats that were treated early in postnatal life with BPA. For this study, lactating dams were gavaged with 250 μg BPA/kg body weight or an equivalent volume of sesame oil on days 1–20 postpartum. On day 21, the female offspring were euthanized and the 4 th  abdominal mammary glands were dissected and frozen in liquid nitrogen for later use. These mammary glands were homogenized and subjected to 2-D gel electrophoresis. The gels were analyzed using  Progenesis Discovery . Protein spots that were common to all gels were statistically evaluated in order to identify significantly regulated spots. Using MALDI-TOF mass spectrometry, we have determined that crystallin β-B2 and heat shock 70kD protein 5 (GRP78) were down regulated and RAD51 homolog 2 was up-regulated in mammary glands of BPA rats compared to control rats. Immuno-blot analysis confirmed the differential regulation and identity of these proteins. Crystallin-β B2, a lens protein, is thought to directly interact with various components of programmed cell death machinery and has previously been found to be a marker of lymph node involvement in breast carcinoma. RAD51 homolog 2 functions in DNA maintenance, participating in a common DNA damage response pathway associated with double-strand break repair, and hence up regulated in cancerous tissue. GRP78, a chaperone protein involved in the folding and assembly of proteins, displays increased expression during times of glucose starvation. Our future interests in this study include measuring glucose concentrations in mammary tissue from the animals treated with BPA in order to establish a correlation between glucose levels and down regulation of GRP78. Furthermore, analysis of differentially regulated biomarkers from 50 day animals and comparison with the 21 day data can yield useful information on developmental changes and protein-protein interaction in detailed biochemical pathways related to BPA exposure. The application of proteomics to mammary carcinogenesis studies should aid in identifying key biomarkers that predetermine mammary cancer susceptibility. Specifically, we should be able to compare proteins that are differentially expressed during mammary gland differentiation (day 21) and at time of sexual maturity (day 50). Supported by NIH/NIEHS 1 U01 ES012771.
Abstract 407: Targeted Hi-C and integrative analyses reveal functionality of colorectal cancer risk loci
Authors: Roland Jäger, Gabriele Migliorini, Marc Henrion, Nicola Whiffin, Laura Broome, Nicola Dryden, Takashi Nagano, Stefan Schoenfelder, Peter Fraser, Olivia Fletcher, Richard Houlston
Journal: Cancer Research (2014)

Abstract Genetic risk factors identified by genome-wide association studies (GWAS) are thought to function through allele-specific regulation of gene expression. Long-range chromatin looping interactions, as revealed by chromosome conformation capture (3C)-based techniques, bring risk variants into spatial proximity with loci otherwise distal on the linear genome. Hi-C, using next generation sequencing (NGS), allows for genome-wide agnostic characterization of chromatin contacts, however, detection of functional enhancer-promoter interactions is precluded by its limited resolution. Here we apply Targeted Hi-C, a novel technique combining the unbiased coverage of Hi-C with target sequence capture to identify functional chromatin interactions for 15 colorectal cancer risk loci at high resolution. We depicted the CRC risk interactome as a set of generic highly significant genome-wide interactions, predominantly overlaying the strongest risk association signals. Integrative analyses involving profiles for epigenetic marks, evolutionary conservation and transcription factor binding, revealed regulatory function of long-range chromatin interactions. At the 8q24.21 risk locus, we could extend a previously reported contact between rs6983267 and the MYC promoter to a network of interactions involving CCAT1 (colorectal cancer associated transcript 1). At other risk loci, our data supports the central role of TERC, BMP4, GREM1, BMP2, SMAD7 and in CRC pathogenesis. Additionally, distal to the risk loci we identified contacts with the genes such as TRPS1, TPO, ETS1, VEZT and RAN, previously implicated in cancer and mutated in CRC. Our results demonstrate the capability of high resolution chromatin interaction analyses in conjunction with combinatorial integrative analyses to decipher disease risk loci. Citation Format: Roland Jäger, Gabriele Migliorini, Marc Henrion, Nicola Whiffin, Laura Broome, Nicola Dryden, Takashi Nagano, Stefan Schoenfelder, Peter Fraser, Olivia Fletcher, Richard Houlston. Targeted Hi-C and integrative analyses reveal functionality of colorectal cancer risk loci. [abstract]. In: Proceedings of the 105th Annual Meeting of the American Association for Cancer Research; 2014 Apr 5-9; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2014;74(19 Suppl):Abstract nr 407. doi:10.1158/1538-7445.AM2014-407
Abstract 2976: Comparison of Efficacy and Durability between Sirolimus-Eluting Stent and Paclitaxel-Eluting Stent in Unprotected Left Main Coronary Arteries: Multicenter Registry in Asia
Authors: Sunao Nakamura, Jang-Ho Bae, Yeo H Cahyadi, Wasan Udayachalerm, Damras Tresukosol, Sudaratana Tansuphaswadikul
Journal: Circulation (2007)

Aim: The aim of this study is to compare the safety and durability of Sirolimus-eluting stent (SES) and Paclitaxel-eluting stent (PES) on the outcome of patients with unprotected left main coronary...
Treatment for<i>Clostridium difficile</i>Infection in Adults
Authors: Cong Dai, Min Jiang, Ming-Jun Sun
Journal: JAMA (2015)

To the Editor Although we agree that the majority of the systematic review1 of best practices for the diagnosis and treatment of C difficile infection in adults was supported by evidence, we have concerns that the conclusions about fidaxomicin may not fully reflect the available clinical data.
Basophil recruitment and activation in inflammatory skin diseases
Authors: Y. Ito, T. Satoh, K. Takayama, C. Miyagishi, A. F. Walls, H. Yokozeki
Journal: Allergy (2011)

To cite this article: Ito Y, Satoh T, Takayama K, Miyagishi C, Walls AF, Yokozeki H. Basophil recruitment and activation in inflammatory skin diseases. Allergy 2011; 66: 1107–1113. Background: Basophils are blood leukocytes constituting less than 1% of leukocytes. They share morphological and functional similarities with mast cells, but recent studies indicate that basophils play non-redundant roles via the release of several cytokines and lipid mediators, as well as functioning as antigen presenting cells. However, basophil infiltration into the tissues in human skin diseases remains to be addressed. Methods: The infiltration of basophils in 24 skin diseases (136 samples) was immunohistochemically analyzed using basophil-specific BB1 antibody. In addition, activation of blood basophils was examined by assessing CD203c expression with flow cytometry. Results: Basophils were detected in skin lesions of atopic dermatitis, prurigo, urticaria, bullous pemphigoid, drug eruptions, eosinophilic pustular folliculitis, insect bites, scabies, Henoch–Schönlein purpura and dermatomyositis. While cell densities in urticaria, bullous pemphigoid and eosinophilic pustular folliculitis were prominent, much lower numbers of basophils were seen in lesional skin of atopic dermatitis. Basophils were entirely absent in psoriasis vulgaris, mastocytosis, tumoral lesions, systemic sclerosis, and systemic lupus erythematosus. Levels of CD203c expression on blood basophils from prurigo and urticaria patients were higher than those from healthy donors. Conclusions: Basophils infiltrate into skin lesions more commonly than previously thought, and thus they may play important roles in a variety of inflammatory skin diseases.
Serum proteomic analysis of lung cancer histologic sub-types
Authors: William Jacot, Ludovic Lhermite, Alain Mange, Thierry Maudelonde, Jerome Solassol, Jean Louis Pujol
Journal: Cancer Research (2006)

Proc Amer Assoc Cancer Res, Volume 47, 2006

4551 

Background: Lung cancer remains the leading cause of cancer-related mortality today. Proteomic approaches are powerful tools to search for differentially expressed proteins because they allow the determination of a panel of biomarkers. Protein expression patterns can be obtained by the SELDI system. The present study was designed to evaluate the SELDI system for (i) evaluating serum proteomic profiles in patients with lung cancer, (ii) optimizing clinico-biological classification of lung cancer sub-types, (iii) identifying and characterizing new relevant proteins in this setting. Methods: Analyses were conducted in a population of 64 histologically confirmed lung cancer patients, 10 small cell lung carcinoma (SCLC), 21squamous cell carcinoma (SCC), 33 adenocarcinoma (AD) cases. To improve the discovery and detection of less abundant proteins, an anion exchange fractionation procedure was performed and serum was separated into six fractions. All fractions were analyzed by SELDI technology. The spectra were generated on weak cation exchange and IMAC-Cu arrays for SELDI analysis. The average coefficient of variance was less than 15%. Univariate statistical analysis was performed using Mann-Whitney test for each pairwise comparison. Protein peaks clustering and classification analyses were made using Ciphergen Biomarker Wizard and Biomarker Pattern software, respectively. Construction of the decision tree classification algorithm was performed using cluster and treewise in order to identify specific proteic profiles of the different histological su-types of lung cancer. Results: Thirteen protein peaks were identified as putative histological differenciation markers, 8 for SCLC, 3 for SCC and 2 for AD differenciation. Decision tree classification algorithm was able to discriminate the SCLC and AD groups using one marker, with a 90% sensitivity and a 50% specificity. Using a combination of 3 markers, discrimination of the SCLC and SCC groups achieved a 66% sensitivity and a 83% specificity. Analysis of the SCC and AD histologic sub-groups using hierarchical cluster analysis showed evidences of the existence of different sub-groups in each histologic population (2 in AD group, 3 in SCC group). Conclusion : These results suggest that serum SELDI protein profiling can distinguish lung cancer histological sub-types with a good sensitivity and specificity, and support the possibility of sub-group differenciation of the lung cancer histological types, as previously described using DNA microarray. Confirmatory studies are ongoing.