tbuckley/cabot-search huggingface dataset:
Increased Rate of Fractures and Severe Kyphosis: Sequelae of Living into Adulthood with Cystic Fibrosis
Authors: Robert M. Aris
Journal: Annals of Internal Medicine (1998)

Osteoporosis occurs in patients with cystic fibrosis as they age, but its clinical implications are not well defined.To determine the clinical effect of decreased bone mineral density in adults with cystic fibrosis and to assess possible clinical predictors of osteoporosis.Retrospective cohort study.Academic cystic fibrosis center.70 adults with late-stage cystic fibrosis who were referred for lung transplantation.Bone mineral density was measured with dual-energy x-ray absorptiometry, patient-reported fracture events were confirmed by radiography, and kyphosis angles were measured by using the Cobb method.Mean bone mineral densities for the spine, femur, and total body were severely depressed in patients with cystic fibrosis, averaging 2 SDs below those of age-matched normal controls (P < 0.001). Patient interviews showed that 54 fractures had occurred over 1410 patient-years, and chest radiographs showed evidence of 14 additional rib and 62 additional vertebral compression fractures. The database (which covered 1410 patient-years) showed that fracture rates were approximately twofold greater in women with cystic fibrosis aged 16 to 34 years (P = 0.015) and men with cystic fibrosis aged 25 to 45 years (P = 0.04) than in the general population. Vertebral compression and rib fractures were 100- and 10-fold more common than expected, respectively (P < 0.001 for both comparisons). The mean kyphosis angle (+/- SD) for this group was markedly abnormal (44 +/- 14 degrees; 62% > or = 40 degrees) and probably contributed to diminished stature (mean height loss, 5.8 cm in men with cystic fibrosis and 5.9 cm in women with cystic fibrosis). Cumulative prednisone dose, body mass index, and age at puberty were the strongest predictors of bone mineral density.Osteoporosis is universal in adults with late-stage cystic fibrosis, and its complications include increased fracture rates and severe kyphosis.
One in eight GP training posts vacant, despite unprecedented third round of recruitment
Authors: A. Rimmer
Journal: BMJ (2014)

Around 12% of GP training posts in England are unfilled for 2014, despite the launch of an unprecedented third round of recruitment to improve fill rates.

Figures from Health Education England show that some areas still have not filled a third of GP training posts and that overall across England 12.4% of posts remain vacant. HEE launched the third recruitment round after the fill rate for GP training places in some areas of England was lower than 70%.1 The East Midlands reported a fill rate of 71% and the North East a …
UK juniors demand more talks on pay offer
Authors: L. Beecham
Journal: BMJ (1999)

Representatives of the United Kingdom's 35 000 junior hospital doctors have sent their leaders back to the negotiating table to push for a better deal on the Department of Health's offer on out of hours pay. They want a special conference and a ballot of BMA junior members on any settlement reached.

The offer came after years of frustration over working conditions and overtime pay. Many juniors are paid at 50% of the standard hourly rate after the first 40 hours of work, and this rate applies to nights, weekends, and bank holidays. This works out at …
Aneurysmlike Formations in Relation to Membranous Ventricular Septum
Authors: RAJENDRA TANDON, JESSE E. EDWARDS
Journal: Circulation (1973)

A left ventriculogram may show an aneurysmal protrusion toward the right ventricle in the subaortic area with or without an associated interventricular communication. The pathologic basis for such a finding is variable. It may well represent an aneurysm of the membranous ventricular septum which may be congenital or acquired. Either variety has the potential of rupturing into the right ventricle. The acquired aneurysms are usually mycotic. An aneurysm resulting from adhesion of the septal leaflet of the tricuspid valve to the rim of a membranous ventricular septal defect and causing complete or incomplete closure may also yield an aneurysmal formation. Pouches of the tricuspid valve resulting from excessive tissue, in association with a ventricular septal defect, can also be misinterpreted as an aneurysm of the membranous septum or as incomplete closure of a ventricular septal defect with aneurysm formation. In some cases, even at pathologic examination, the exact nature is difficult to identify. Separation of a true aneurysm of the membranous septum with adherent tricuspid valve from a spontaneously closed ventricular septal defect with aneurysmlike protrusion in the septal leaflet may not be possible.
Beta-Adrenergic-Antagonist Therapy for Hyperthyroid Graves' Disease
Authors: Robert D. Utiger
Journal: New England Journal of Medicine (1984)

Five years ago Toft and co-workers described their experience with propranolol for preoperative therapy in patients with hyperthyroidism due to Graves' disease.1 The results were excellent in terms of amelioration of the clinical manifestations of hyperthyroidism, minimal perioperative morbidity, and rapid return of thyroid hormone secretion to normal. What has been the impact of this form of preoperative therapy for the surgical treatment of this disease?In the ensuing years, several additional reports confirmed the efficacy and safety of preoperative therapy with propranolol or newer beta-adrenergic-antagonist drugs.2 3 4 The use of these agents allows surgery to be undertaken after one to . . .
AVULSION OF THE ANTERIOR SUPERIOR ILIAC SPINE, WITH SYMPTOMLESS SACRALIZATION OF THE FIFTH LUMBAR VERTEBRA
Authors: Edward P. Heller
Journal: JAMA (1925)

This case illustrates a rather rare type of fracture, and incidentally shows a complicating spinal anomaly which has not produced symptoms and which is of some medicolegal interest. <h3>REPORT OF CASE</h3> E. W., a youth, aged 17 years and 8 months, employed as a yard messenger by a railroad company, was sent home from work, April 10, 1924, because of extreme pain in the region of the left groin. He was referred to me by Dr. W. D. Middleton, who thought from the severity of the pain manifested by the lad that he had ruptured a viscus. The youth was of athletic build, about 5 feet, 10 inches (178 cm.) tall, and lay on his back in bed with the head and chest slightly elevated on a pillow. He complained bitterly of pain in the left groin, but said he was fairly comfortable as long as he did not move.
Treatment Options for Asymptomatic Carotid Artery Stenosis
Authors: Kosmas I. Paraskevas, Frank J. Veith
Journal: JAMA (2014)

Dr Beckman1 discussed the available options for the management of asymptomatic carotid artery stenosis, using a 78-year-old female patient with severe stenosis as the case. Beckman summarized the results of the Carotid Revascularization Endarterectomy Versus Stenting Trial (CREST),2 demonstrating that in asymptomatic patients, carotid artery stenting (CAS) is associated with similar outcomes compared with carotid endarterectomy (CEA). The patient preferred revascularization over optimal medical therapy and consequently underwent uneventful CAS.1
Stress echocardiography in elderly patients with coronary artery disease Applicability, safety and prognostic value of dobutamine and adenosine echocardiography in elderly patients
Authors: Lambros P. Anthopoulos, Maria S. Bonou, Fotis G. Kardaras, Elias P. Sioras, Dimitra N. Kardara, Antonis M. Sideris, Athanassios I. Kranidis, Nicholaos G. Margaris
Journal: Journal of the American College of Cardiology (1996)
WHO's response to article on doctors and the alcohol industry
Authors: M. Chan
Journal: BMJ (2013)

WHO agrees with many, but not all, points made in the BMJ articles on the alcohol industry.1 2 References to the WHO Global Strategy to Reduce the Harmful Use of Alcohol require clarification, particularly claims that industry is simply doing “what WHO asked for in the strategy.” Not so.

The strategy, which was unanimously endorsed by WHO member states …
Practice Expenses and Ancillary Help
Authors: W. A. Pritchard
Journal: BMJ (1964)

BRyUHdoctor with 3,000 patients has not been subsidizing the doctor with 1,500 patients- rather the reverse.If a direct payment for ancillary help is given to the doctor with 3,000 patients (that is the doctor with ancillary help) it would result in the small-list doctor without ancillary help subsidizing still more the large- list doctor.For this reason, the present pro- posed scheme should definitely be abandoned as being inequitable, and perhaps a scheme fairer to all could be evolved.If not, I should leave well alone, as the large-list doctor is already receiving higher practice expenses, with which he can pay for his ancillary help.-Iam, etc., Glasgow S.i.
Modern Trends in Infertility and Conception Control
Authors: Alex S. Tulsky
Journal: JAMA (1979)

This book is a compilation of 36 contributions to the fields of infertility, reproductive endocrinology, and conception control from the Journal of Fertility and Sterility . It is generally a well-written volume, but there is some unevenness in the quality of the individual chapters ranging from the mundane on Traumatic Hypomenorrhea-Amenorrhea, to the excellent and sophisticated Current Concepts of Prolactin Physiology in Normal and Abnormal Conditions.  In general, there is a good mix involving diagnosis and management of clinical problems and assessment of new techniques in the laboratory and in the treatment rooms. Some overlapping of material exists, but it is unobtrusive. Endoscopy, although referred to by a number of authors, does not have a separate chapter. A social and historical review of male contraception and family planning is an often-neglected and, therefore, welcome addition to this volume.  The few tables, graphs, and figures are clear. Most chapters have extensive bibliographies.
Antibiotic halves number of AIDS related deaths in children in Zambian study
Authors: Debashis Singh
Journal: BMJ (2004)

All children with HIV in developing countries should be given prophylactic co-trimoxazole, a cheap and widely available antibiotic, a research paper from the Medical Research Council says ( Lancet 2004;364:1865-71).

The study found that a daily dose of the antibiotic resulted in a 43% lower mortality in children with HIV in Lusaka, Zambia, who were treated with the antibiotic than in a matched group of children taking a placebo, by preventing opportunistic infections irrespective of local antibiotic resistance. Co-trimoxazole also reduced admission rates to the University Teaching Hospital in Lusaka …
The Mismatch Repair Protein Msh6 Influences the In Vivo AID Targeting to the Ig Locus
Authors: Ziqiang Li, Chunfang Zhao, Maria D. Iglesias-Ussel, Zhanna Polonskaya, Min Zhuang, Guozhe Yang, Zhonghui Luo, Winfried Edelmann, Matthew D. Scharff
Journal: Immunity (2006)
Fatal complication after endoscopic ultrasound-guided celiac plexus neurolysis
Authors: A. Gimeno-García, A. Elwassief, S. Paquin, A. Sahai
Journal: Endoscopy (2012)

A 57-year-old woman with a diagnosis of idiopathic recurrent pancreatitis and progressive epigastric pain radiating to her back was admitted to the hospital. Abdominal computed tomography (CT) showed a suspicious 3-cm pancreatic head mass involving the superior mesenteric artery (SMA) and vein. Endoscopic ultrasound (EUS) showed the suspicious pancreatic head mass with bile duct and main pancreatic duct dilatation and changes compatible with chronic pancreatitis. However, EUS-guided fine needle aspiration cytology was negative on three occasions.
Financial Consequences of Drug Benefit Plans
Authors: Brenda Motheral, Jagat Sheth
Journal: JAMA (2003)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Abstract 3663: A gene signature for predicting outcome in patients with basal-like breast cancer
Authors: Robin M. Hallett, Anna Dvorkin-Gheva, Anita Bane, John A. Hassell
Journal: Cancer Research (2012)

Abstract Basal-like breast cancer is a molecular subtype of breast cancer generally thought to have a universally poor prognosis. Subsequent studies examining the long-term outcome in thousands of patients with basal-like breast cancer have shown that these patients can be separated into two clinically distinct groups: those likely to experience a systemic recurrence and succumb to their disease within the first 5 years and those expected to show excellent long term survival. The ability to distinguish between these two sub-groups (good and poor prognosis) of basal-like breast cancer patients at the time of initial diagnosis would permit tailoring more aggressive therapeutic regimens to those patients with an inherently poorer prognosis and conversely to avoid such therapy in patients with a more indolent course. We aimed to identify a gene signature that could predict the clinical outcome of basal-like breast cancer patients. To this end we mined publicly available human breast tumor gene expression profiling data and identified patients with basal-like breast cancer. We divided these patients into training and validation sets to identify and confirm the accuracy of a prognostic signature. We identified 137 basal-like breast tumors among 995 breast tumor gene expression profiles. We used 85 of these samples as a training group and identified an optimal 14-gene signature, which accurately identified patients that experienced poor and good long-term survival. We confirmed the accuracy of our gene signature on a 49 patient independent validation set. Importantly, we also confirmed the capacity of our signature to predict outcome in a chemotherapy naïve 27 patient sub-set of the 49 patients validation set. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 103rd Annual Meeting of the American Association for Cancer Research; 2012 Mar 31-Apr 4; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2012;72(8 Suppl):Abstract nr 3663. doi:1538-7445.AM2012-3663
Design and development of TT30, a novel C3d-targeted C3/C5 convertase inhibitor for treatment of human complement alternative pathway–mediated diseases
Authors: Masha Fridkis-Hareli, Michael Storek, Istvan Mazsaroff, Antonio M. Risitano, Ante S. Lundberg, Christopher J. Horvath, V. Michael Holers
Journal: Blood (2011)
Mechanical and Myocardial Factors in Chronic Constrictive Pericarditis
Authors: RAJANE M. HARVEY, M. IRENÉ FERRER, RICHARD T. CATHCART, DICKINSON W. RICHARDS, ANDRÉ COURNAND
Journal: Circulation (1953)

The hemodynamic findings in five patients are presented in order to demonstrate the variability in the clinical and physiologic patterns that may be encountered in restrictive disease of the pericardium. The mechanical effects of pericardial encasement previously described were confirmed. Furthermore, it was found that myocardial insufficiency and hypervolemia were not only important causative agents in the circulatory dysfunction but were in some measure reversible, thus permitting resolution of the congestive state and disappearance of the "typical" hemodynamic findings of constrictive pericarditis.
THE SPECIFIC AMINO ACID REQUIREMENTS OF A HUMAN CARCINOMA CELL (STRAIN H<scp>E</scp>L<scp>A</scp>) IN TISSUE CULTURE
Authors: Harry Eagle
Journal: The Journal of Experimental Medicine (1955)

The amino acid requirements of a human uterine carcinoma cell (HeLa strain) have been defined. The 12 compounds previously found to be essential for the growth of a mouse fibroblast proved similarly essential for this human epithelial cell. They included arginine, cyst(e)ine, histidine, and tyrosine, in addition to the eight amino acids required for nitrogen balance in man (isoleucine, leucine, lysine, methionine, phenylalanine, threonine, tryptophan, and valine). Only the L-amino acids were active; the D-enantiomorphs had no demonstrable effect at physiologic concentrations. The minimum concentrations required for survival and limited growth varied from 0.003 µM per ml. for L-tryptophan, to 0.1 µM per ml. for L-lysine. The concentrations permitting optimum growth similarly varied from 0.01 µM per ml. for tryptophan, to 0.1 µM per ml. for leucine, isoleucine, threonine, lysine, and valine. The latter optimum concentrations of the individual amino acids were closely correlated with their serum levels. With at least six of the amino acids, high concentrations, in the range 1 to 10 µM per ml., caused a definite growth inhibition. In the absence of a single essential amino acid, degenerative changes occurred in the cells, culminating in their death and dissolution. In the early stages, however, these degenerative changes could be reversed by the restoration of the missing component.
LICHEN PLANUS OF THE ORAL MUCOSA.WITH REPORT OF TWO CASES.
Authors: DAVID LIEBERTHAL
Journal: JAMA (1907)

In his work on "Differentialdiagnose von Dermatosen und Lues bei den Schleimhauterkrankungen der Mundhoehle, etc.," Trautmann gives a carefully prepared review of the 72 cases of lichen planus of the mucous membranes published up to 1903. There are other cases mentioned in literature, but very briefly. Considering the comparatively frequent occurrence of lichen planus of the skin, the localization of the process on the mucous membranes is rather rare, and it is interesting to note that this subject is rarely and only recently touched on in American literature. Among the cases cited by Trautmann none is from an American author. The importance of this affection is evidenced by the fact that it may easily be confounded with syphilis. There are cases of lichen planus which have a distribution limited to the palms of the hands or to the soles of the feet, or to the penis or to the scrotum,
Rifampicin containing antituberculosis medication
Authors: G F CAVELL, D C S HUTCHISON, B C WHITEMAN
Journal: Thorax (1998)

We wish to draw attention to the potential for error in the prescribing and dispensation of antituberculous drugs containing rifampicin.

Most prescriptions for patients with tuberculosis contain rifampicin; this drug must be administered with other chemotherapeutic agents, most commonly isoniazid and pyrazinamide, in order to avoid the emergence of drug resistant organisms. Patient compliance is much improved by the prescription of “combination therapy”.

Guidelines for the management of tuberculosis are available1 and the drug regimens specified by the Joint Tuberculosis Committee of the …
Reactive or infectious arthritis
Authors: J. G KUIPERS, L. KOHLER, H. ZEIDLER
Journal: Annals of the Rheumatic Diseases (1999)

BACKGROUND-- The first successful single lung transplantation was carried out in 1983 for pulmonary fibrosis. Because of the inherent advantages of single lung transplantation, a transplantation programme has been started for patients with end stage lung disease due to emphysema. METHODS-- Between October 1990 and August 1993 25 patients with severe emphysema (15 men, mean age 51 years) received a single lung transplant at our institution. All patients were severely disabled with a mean (SD) 12 minute walking distance of 281 (165) metres. There were five deaths in the series, four in the first 20 days and one on day 503. Two patients suffered graft compression by air trapping in the native lung. Bronchial narrowing requiring insertion of endobronchial stenting occurred in four patients. RESULTS-- Mean (SD) FEV1 improved from a preoperative value of 17.8(13%) predicted to a six month value of 53.6(13)%, and FEV1/FVC from 23.8(12)% to 68.6(15)%. After the transplant 12 patients are in New York Heart Association (NYHA) class I and the rest of the survivors are in NYHA II. Actuarial survival was 82% at one year and 74% at three years. CONCLUSIONS-- Single lung transplantation is an effective treatment for end stage lung disease due to emphysema and carries an acceptable mortality and morbidity.
Recombinant allergens Pru av 1 and Pru av 4 and a newly identified lipid transfer protein in the in vitro diagnosis of cherry allergy
Authors: Stephan Scheurer, Elide A. Pastorello, Andrea Wangorsch, Marion Kästner, Dieter Haustein, Stefan Vieths
Journal: Journal of Allergy and Clinical Immunology (2001)
Experimental autoimmune myasthenia: A model of myasthenia gravis in rats and guinea pigs.
Authors: V A Lennon, J M Lindstrom, M E Seybold
Journal: The Journal of Experimental Medicine (1975)

Immunization of animals with acetylcholine receptor (AChR) protein from the electric organs of Electrophorus electricus and Torpedo californica induces an autoimmune response to the AChR of mammalian skeletal muscle. Rats and guinea pigs develop experimental autoimmune myasthenia gravis (EAMG) after a single inoculation with small quantities of AChR and adjuvant. The indicence and severity of disease appears to depend on the dose of AChR and stability of the emulsion. EAMG is strikingly similar to myasthenia gravis (MG) of man in its clinical picture and its electrophysiological abnormalities. The presence of antibodies to syngeneic rat muscle AChR in the serum of rats with EAMG documents the existence of autoimmunity in the experimental disease. A common immunopathogenesis is suggested for both EAMG and mg.
Bruton tyrosine kinase mediates TLR9-dependent human dendritic cell activation
Authors: Vassilios Lougaris, Manuela Baronio, Massimiliano Vitali, Giacomo Tampella, Marco Cattalini, Laura Tassone, Annarosa Soresina, Raffaele Badolato, Alessandro Plebani
Journal: Journal of Allergy and Clinical Immunology (2014)
Technetium-99m pyrophosphate uptake in experimental viral perimyocarditis. Sequential study of myocardial uptake and pathologic correlates.
Authors: A Matsumori, K Kadota, C Kawai
Journal: Circulation (1980)

The myocardial uptake of technetium-99m pyrophosphate (99mTc-PYP) in perimyocarditis induced by coxsackievirus B3 in BALB/c mice was studied. 99mTc-PYP uptake ratio, measured by the ratio of counts/min per gram for the heart to counts/min per gram for the skull, began to increase 5 days after virus inoculation when myocardial necrosis was evident. On the seventh day after the inoculation, 99mTc-PYP ratio reached a maximum. Histologically, fine, dystrophic calcification appeared in the necrotic fibers. 99mTc-PYP uptake was in proportion to the extent of the myocardial lesions. Thereafter, cellular infiltrations increased with time and were most severe on the fourteenth day, but 99mTc-PYP ratio had begun to fade. On the twenty-eighth day, perimyocardial fibrosis increased and calcification was still present, but 99mTc-PYP ratio had decreased. Myocardial uptake with severe pathologic lesions was visualized on a whole-body image on the seventh day after inoculation with the virus. The findings may provide a basis upon which 99mTc-pyp imaging may be applied to viral perimyocarditis in humans.