tbuckley/cabot-search huggingface dataset:
Compliance with an injury prevention program in dutch adult male amateur soccer
Authors: A van Beijsterveldt, M Krist, I van de Port, F Backx
Journal: British Journal of Sports Medicine (2011)

Background Compliance with and attitudes towards injury prevention programs, like ‘The11’ (from FIFA), can influence the effectiveness of such programs. Objective The aim of this study is to monitor the use of the ‘The11’ during practice sessions in one season and to determine opinions of coaches and players concerning this program. Design This study is part of a cluster-randomised controlled trial on the effectiveness and cost-effectiveness of ‘The11’. Setting First class amateur teams from one district in the Netherlands participated in this study. They all had practice sessions 2–3 times a week. Participants Male players aged 18–40 years were eligible for inclusion in the study. 10 teams, including 212 players, participated and were followed for one season (September 2009–June 2010). Intervention The participating teams were instructed to perform ‘The11’, during each practice session throughout the season. Main outcome measurements Compliance of all players was registered each session by the coaches. At the end of the season coaches as well as players were asked to fill in a questionnaire to assess their attitudes towards ‘The11’ and injury prevention in general. Results Preliminary results show that teams completed ‘The11’ in 81% of all practice sessions and players in 84% of the sessions they attended. All the coaches (n=12) stated that including injury prevention in the practice sessions is important. 53% of the players returned their questionnaire (n=110). Of them 54.8% was moderately to highly motivate to perform ‘The11’ during each practice session. On average a third of the players mentioned every exercise as ‘boring’. Coaches and players believed that ‘bench’, ‘sideways bench’ and ‘hamstrings’ are the most important three (from 10) exercises to prevent soccer injuries. Conclusion More extensive results of this study are expected in February 2011. Also the correlations between compliance, attitudes and injuries can be presented in Monaco.
FOREIGN BODY ABSCESS OF THE PANCREAS
Authors: Robert S. Baldwin
Journal: JAMA (1935)

Although diffuse pancreatitis occurs with sufficient frequency to warrant its being included in the differential diagnosis of most abdominal disorders, a localized suppurative process in the pancreas is rarely seen. I report here the observations made on a patient with an abscess of the head of the pancreas which surrounded a foreign body resembling a toothpick. So far as I could determine, no similar case has been observed heretofore. <h3>REPORT OF CASE</h3> J. M., a man, aged 40, a farmer, was admitted to the hospital, July 18, 1934, after a tentative diagnosis of typhoid had been made. He said that his illness had begun three weeks previously with an infection of the upper respiratory tract. Chills and fever, epigastric pain, vomiting and diarrhea occurred soon afterward, and he had been in bed for two and one-half weeks. In addition, he noticed loss of appetite, headaches and dark colored urine.
Uses and Abuses of Prescription Drug Information in Pharmacy Benefits Management Programs
Authors: Bernard Lo
Journal: JAMA (2000)

A 1998 incident in which patients' prescription information was used to advertise a new drug exemplifies the importance of confidentiality in the era of managed care and computers. The ethical concerns voiced about this incident can also apply to pharmacy benefits management programs. The use of personal health information in pharmacy benefits management is particularly important because of increased pressures to control rising drug costs. Specific confidentiality concerns include whether the goal of benefiting patients will be achieved and whether the means are appropriate. The means may be problematic because of financial conflicts of interest, lack of patient authorization, inappropriate access to information by third parties, and inadequate safeguards for confidentiality. Policies should be crafted that protect confidentiality while allowing appropriate use of personal health information in pharmacy benefits management. Sound policies should require clear evidence of benefit to patients, an oversight committee, patient authorization, disclosure or prohibition of conflicts of interest, additional safeguards for sensitive medical conditions, strong confidentiality protections, and restrictions on advertising.
Polymorphic light eruption with contact and photocontact allergy
Authors: K.J. GUDMUNDSEN, GILLIAN M. MURPHY, DOROTHY O'SULLIVAN, F.C. POWELL, S. O'LOUGHLIN
Journal: British Journal of Dermatology (1991)

Journal Article Polymorphic light eruption with contact and photocontact allergy Get access K.J. GUDMUNDSEN, K.J. GUDMUNDSEN Department of Dermatology, Mater Hospital, Dublin, Republic of Ireland Search for other works by this author on: Oxford Academic Google Scholar GILLIAN M. MURPHY, GILLIAN M. MURPHY Department of Dermatology, Mater Hospital, Dublin, Republic of Ireland Dr G. M. Murphy, Department of Dermatology, Mater Misericordiae Hospital, Dublin 7, Republic of Ireland. Search for other works by this author on: Oxford Academic Google Scholar DOROTHY O'SULLIVAN, DOROTHY O'SULLIVAN Department of Dermatology, Mater Hospital, Dublin, Republic of Ireland Search for other works by this author on: Oxford Academic Google Scholar F.C. POWELL, F.C. POWELL Department of Dermatology, Mater Hospital, Dublin, Republic of Ireland Search for other works by this author on: Oxford Academic Google Scholar S. O'LOUGHLIN S. O'LOUGHLIN Department of Dermatology, Mater Hospital, Dublin, Republic of Ireland Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 124, Issue 4, 1 April 1991, Pages 379–382, https://doi.org/10.1111/j.1365-2133.1991.tb00603.x Published: 01 April 1991
An introduction to cells.
Authors: L Wolpert
Journal: BMJ (1987)

Cells are the triumph of evolution.1 The rest of evolution can be thought of as an elaboration on this masterpiece. In some ways they are more complex than the organs to which they give rise, with the possible exception of the brain, in that their behaviour reflects the integrated activity of about 50000 genes, their products, and the complex biochemical and structural networks that result. In this biochemical network there are two different timescales. The first, which responds to changes in seconds or fractions of a second, is that concerned with metabolism. The enzymes in the cell cytoplasm, including the mitochondria, catalyse molecules along narrowly defined reaction pathways such as the Krebs cycle, the synthesis of purines, or the breakdown of carbohydrates. Many of these reactions require or generate energy in the form of adenosine triphosphate. The speed of response of these metabolic pathways can be contrasted with those in the second system, which entails the synthesis of macromolecules such as nucleic acids and proteins. Here the response times are minutes to hours. Understanding the integration of these two interdependent pathways is a major problem in cell biology.
Abstract 364: Coat color mutations alter angiogenic responsiveness
Authors: Michael S. Rogers, Amy E. Birsner, Robert J. D'Amato
Journal: Cancer Research (2010)

Abstract Angiogenesis is the process by which new blood vessels are formed from existing vessels. Mammalian populations, including humans and mice, harbor genetic variations that alter angiogenesis. Angiogenesis-regulating gene variants can result in increased susceptibility to multiple angiogenesis-dependant diseases in humans. Our efforts to dissect the complexity of the genetic diversity that regulates angiogenesis have used laboratory animals due to the availability of genome sequence for many species and the ability to perform high volume controlled breeding. Using the murine corneal micropocket assay, we have observed more than ten-fold difference in angiogenic responsiveness among various mouse strains. This degree of difference is observed with either bFGF or VEGF induced corneal neovascularization. Ongoing mapping studies have identified multiple loci that control angiogenic responsiveness in several mouse models. We have identified the polymorphism responsible for two of these loci. Using composite interval mapping and multiple interval mapping in crosses involving C57BL/6J, A/J, and SJL/J strains, we have confirmed the existence of multiple angiogenesis-response loci on chromosome 7. One of these (AngVq4) localized to the middle of the chromosome and was centered on tyrosinase. Congenic animals confirmed this locus, but could not demonstrate that the classical tyrosinase albino (c) mutation was causative because of the existence of additional linked loci in the congenic. In 1970, a second tyrosinase albino mutation (c-2J) arose in the C57BL/6J background at Jackson Labs. Testing this strain (C57BL/6J&amp;lt;c-2J&amp;gt;) demonstrated that the albino mutation is sufficient to completely explain the alteration in angiogenic response that we observed in congenic animals. Thus, we conclude that the classical tyrosinase mutation is responsible for AngVq4. Similar methods have identified the classical pink-eyed dilution mutation as the genetic change responsible for AngFq5. Characterizing novel angiogenesis regulating genes detected by QTL mapping may identify additional therapeutic targets for antiangiogenic agents. These experiments also reveal the important effect of the host genetics on angiogenesis and tumor growth. The identification of “high angiogenic” individuals which are at risk for angiogenesis dependent diseases will allow for increased monitoring and better clinical management. Further, new antiangiogenic therapies with low toxicity may allow for the pretreatment of such individuals rendering them “low angiogenic” and thereby increase survival. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 101st Annual Meeting of the American Association for Cancer Research; 2010 Apr 17-21; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2010;70(8 Suppl):Abstract nr 364.
Medical Societies Unite Against Firearm Injuries
Authors: Thomas B. Cole
Journal: JAMA (2001)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Renal D3 dopamine receptor stimulation induces natriuresis by endothelin B receptor interactions
Authors: Chunyu Zeng, Laureano D. Asico, Changqing Yu, Van Anthony M. Villar, Weibin Shi, Yingjin Luo, Zheng Wang, Duofen He, Yan Liu, Lan Huang, Chengming Yang, Xukai Wang, Ulrich Hopfer, Gilbert M. Eisner, Pedro A. Jose
Journal: Kidney International (2008)
When to stop a clinical trial.
Authors: S. J. Pocock
Journal: BMJ (1992)

Most randomised clinical trials require periodic monitoring of the accumulating data.While the efficiency of trial management is enhanced by data monitoring, ethical reasons should primarily dictate the need to terminate or change a trial in response to interim findings.This article focuses on the ethical dilemma of when to stop a clinical trial and places statistical stopping rules in the context of such ethical decision making.Other issues include the organisation of data monitor- ing committees and the problems of premature publication and exaggerated estimation in trials that stop early.Several topical examples are used to convey the relevance of these issues to current practice.* Though the early sequential methodology is related to continuous monitoring of the gradually accumulat- ing data,"' it is usually more acceptable to adopt a "group sequential" approach with a limited number of preplanned interim analyses before each data monitoring committee meeting'"
Immunological Tolerance to Inhaled Antigen
Authors: GERARD F. HOYNE, KAREN TAN, MARTA CORSIN-JIMENEZ, KAREN WAHL, MAIRI STEWART, SARAH E. M. HOWIE, JONATHAN R. LAMB
Journal: American Journal of Respiratory and Critical Care Medicine (2000)

Regulatory mechanisms exist in the immune system to limit the induction of pathogenic responses to antigens encountered within the respiratory tract. The development of allergic disease is thought to arise as a result of the breakdown in these regulatory processes. In this review we examine the nature of immune responses generated to inhaled protein antigens and the mechanisms used to establish tolerance to inhaled antigens.
Suspension of consultant raises serious issues
Authors: G. Graham, T. Robinson
Journal: BMJ (1998)

EDITOR—The recent news item1 and the subsequent letter and correction2 about the hearing of Dr James Taylor before the General Medical Council have not taken account of some serious issues raised by this case, which will affect interventional physicians, cardiologists, and radiologists as well as obstetricians, surgeons, and others.

The accusation had been about consent, not of medical negligence. Negligence forms no part of the hearing. At issue was the extent to which consent is covered in the standard consent form used in NHS hospitals. After lengthy debate by counsel …
Psychiatry, Give Us Tools, Not Talk
Authors: J. NEAL GREENE
Journal: Annals of Internal Medicine (1976)

Comments1 October 1976Psychiatry, Give Us Tools, Not TalkJ. NEAL GREENE, M.D.J. NEAL GREENE, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-85-4-542_2 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: There seems to be an incessant tide of criticism of the practicing physician in medical literature. Twenty years ago the subspecialties held the stage, but now the "holistic" view is in style. Dr. Menninger's editorial (Ann Intern Med84:603-604, 1976) and many others flay us for not treating the "whole person," and for showing "little interest" in promoting it." The longer I practice as an internist, the more I realize that psychiatry has very little to offer my patients. We are beginning to understand the human body, but we know almost nothing about the mind. The lapse... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 October 1976Volume 85, Issue 4Page: 542-542 Issue Published: 1 October 1976 PDF DownloadLoading ...
ELEVEN YEARS OBSERVATION IN THE USE OF CREASOTE, IN THE TREATMENT OF TUBERCLE OF THE LUNGS.
Authors: J. O. COBB
Journal: JAMA (1896)

For eleven years I have had a greater or less number of patients constantly under observation with the creasote treatment, and feeling the importance of the subject and the general interest taken in this disease, I have been led to report my experience. A large majority of patients have been seamen of the merchant marine. The conditions noted cover all stages of the disease. The places of observation were South Carolina, Texas, different stations on the Great Lakes, a few cases at Evansville and St. Louis and the remainder at Port Townsend, Washington. A majority of the cases were not diagnosticated by bacteriologic examination as physical methods easily revealed the condition. All cases of "chronic pneumonic phthisis," "chronic pneumonia," etc., are excluded. Pure beechwood creasote was given throughout. Dosage ranging from one to seventy minims, has been tried. Some cases have been treated to a termination with a few minims
Your Very Good Health
Authors: Lewis Thomas
Journal: New England Journal of Medicine (1972)

WE spend $60 billion a year on health, as we keep reminding ourselves, or is it now 70? Whichever, it is a socking sum, and just to mention it is to suggest the presence of a vast, powerful enterprise, intricately organized and co-ordinated. It is, however, a bewildering, essentially scatterbrained kind of business, expanding steadily without being planned or run by anyone in particular. Whatever sum we spent last year was only discovered after we'd spent it, and nobody can be sure what next year's bill will be. The social scientists, attracted by problems of this magnitude, are beginning to . . .
THE DESTINY OF VAGINAL HYSTERECTOMY FOR MALIGNANT DISEASE.
Authors: C. LESTER HALL
Journal: JAMA (1897)

It is not my expectation to present any strikingly new features in reference to the subject. I would offer, rather, a few conclusions gleaned from personal experience and from the current literature of today, with the hope that a liberal discussion will follow, the crystallization of which may result in good and lead to a clearer understanding of the conditions met with in malignant uterine disease, and the more rational surgical procedures indicated for the removal of the same. So far as this occasion is concerned, it matters not whether we accept Cohnheim's theory that "the only cells capable of originating neoplasms are those sequestered during embryonic life," or with Williams believe that "neoplasms are of intrinsic origin, due to a modification of the formative process by abnormal forces generated within the body, rather than extrinsic, due to inflammation or to the intrusion of microorganisms," or favor the more recent
Coincidental occurrence of pernicious anemia and mycosis fungoides in two elderly males
Authors: Takayuki Saitoh, Hirokazu Murakami, Kumiko Hayashi, Takafumi Matsushima, Jun'ichi Tamura, Masamitsu Karasawa, Takuji Naruse, Jun Tsuchiya
Journal: American Journal of Hematology (1998)

We experienced two rare cases of pernicious anemia that presented in the course of mycosis fungoides in elderly males. Pernicious anemia has recently been reported to be caused by autoimmune gastritis that produces autoantibodies to gastric parietal cells and intrinsic factor. Immunological abnormalities in mycosis fungoides are reported to induce autoimmune diseases (i.e., autoimmune hemolytic anemia, anti-phospholipid antibody syndrome, arthritis, myasthenia gravis, necrotizing vasculitis, and vitiligo); the pernicious anemia in our two patients may have been closely related to the mycosis fungoides. Am. J. Hematol. 58:127–129, 1998. © 1998 Wiley-Liss, Inc.
Histogenesis of exocrine pancreatic cancer in the hamster model.
Authors: P M Pour
Journal: Environmental Health Perspectives (1984)

There is strong evidence that induced pancreatic adenomas and carcinomas derive from ductal and ductular cells in the pancreas. We base our beliefs on our knowledge of the embryology and histology of the pancreas in Syrian golden hamsters, along with the sequential alterations that occur during exocrine pancreatic tumor formation. This concept also has been supported by much experimental evidence, including autoradiographic, immunologic and in vitro studies. We also present other viewpoints on the origin of pancreatic cancer histogenesis and outline certain areas of disagreement. We report the development of acinar cell lesions under certain experimental dietary conditions in hamsters (the lesions resemble those commonly seen in the rat pancreatic tumor model) and the nature of these lesions.
Junior Hospital Doctors' Contract
Authors: G. M. Addison, J. S. Dinnen, R. D. Hutton, M. Khurshid, S. Mayne, E. Owen, D. J. Reynolds, A. J. Slater, E. G. D. Tuddenham, E. M. Spiers, D. A. White, C. Anand, A. R. Gibbs, D. H. M. Joynson, J. Marples, G. R. Melville-Jones, A. Napier, D. H. Parry, K. B. Robinson, R. J. Thompson, D. P. Bentley, G. J. Griffiths
Journal: BMJ (1975)

the leadership was proved to be wrong.When we, the General Medical Services Commnittee negotiators, met her she was very reasonable and gave us assurances.However, we would have been pilloried, and rightly so, if we had accepted them without warning her that the collection of resignations was likely.Under stress politicians unite but our pro- fession fragments.Dr.
Some First Steps Toward Responsible Use of Cognitive-Enhancing Drugs by the Healthy
Authors: Henry T. Greely
Journal: The American Journal of Bioethics (2013)

In December 2008 Barbara Sahakian, John Harris, Ronald C. Kessler, Michael Gazzaniga, Philip Campbell, Martha J. Farah, and I published a commentary in Nature entitled “Towards Responsible Use of C...
Combined mTOR inhibitor rapamycin and doxorubicin-loaded cyclic octapeptide modified liposomes for targeting integrin α3 in triple-negative breast cancer
Authors: Wenbing Dai, Fang Yang, Ling Ma, Yuchen Fan, Bing He, Qihua He, Xueqing Wang, Hua Zhang, Qiang Zhang
Journal: Biomaterials (2014)
A third of cardiac arrests in hospital could have been prevented, finds inquiry
Authors: S. Mayor
Journal: BMJ (2012)

Better assessment of patients when they are admitted to hospital and an improved response when they deteriorate could have prevented cardiac arrest and subsequent resuscitation attempts in a third of cases of arrest occurring in hospitals, concludes an inquiry.

A multidisciplinary team that included consultants in emergency care and cardiology from the National Confidential Enquiry into Patient Outcome and Death (NCEPOD) reviewed data on all adult patients who had a cardiac arrest in hospital and underwent a resuscitation attempt in England, Wales, Northern Ireland, the Channel Islands, and the Isle of Man between 1 and 14 November 2010.1

The team looked at patients’ case notes and at questionnaires completed by the clinician responsible for the patient when the arrest occurred and by the hospital, together with a resuscitation form completed …
THE SYNTHESIS OF A TETRADECAPEPTIDE RENIN SUBSTRATE
Authors: Leonard T. Skeggs, Kenneth E. Lentz, Joseph R. Kahn, Norman P. Shumway
Journal: The Journal of Experimental Medicine (1958)

A tetradecapeptide renin substrate having a biological activity comparable to the natural product and similar chemical properties has been synthesized by means of the carbobenzyloxyl azide and mixed anhydride methods.
Colon Carcinoma and the Cancer Family Syndrome
Authors: Rolf D. Arndt
Journal: JAMA (1977)

THE CONCEPT of "cancer families" was first introduced in the early part of this century and refers to those kindreds with a high incidence and early onset of adenocarcinoma in various organs, but particularly the colon. The incidence of adenocarcinoma of the colon is well recognized to be increased in familial syndromes associated with colon polyps. Recently, however, a prevalence of this carcinoma without colonic polyps has been described in families.<sup>1</sup> We have observed carcinoma of the colon in a mother and a daughter and an adenomatous polyp in the son. All occurred at an early age and were located in essentially the same region of the large bowel. <h3>Report of a Case</h3> The mother is a 54-year-old woman hospitalized in January 1974 at St John's Hospital and Health Center, Santa Monica, Calif, with sudden onset of abdominal pain and fever. Barium enema examination showed a 2.5-cm annular mass