tbuckley/cabot-search huggingface dataset:
Evaluation of Outcome of Intravenous Catheter-related Infections in Critically Ill Patients
Authors: JORDI RELLO, ANA OCHAGAVIA, ELENA SABANES, MARTA ROQUE, DOLORS MARISCAL, ESTEBAN REYNAGA, JORDI VALLES
Journal: American Journal of Respiratory and Critical Care Medicine (2000)

Fifty-seven patients developed an episode of catheter-related infection (CRI) in the bloodstream during their stay in the intensive care unit (cases) and were prospectively observed to establish the attributable mortality, increase in length of stay, and excess costs. Costs were estimated by multiplying the number of excess days of stay by the reimbursement provided. The outcomes for these cases were compared with those for matched control subjects without CRI. Eight cases were excluded as no control was found. Of the 49 cases, 31 were coagulase-negative staphylococci (CNS). The level of severity was similar for both groups (APACHE II 15.5 +/- 7. 2 versus 15.2 +/- 7.3). There were no significant differences (p > 0. 20) in the mortality observed in the hospital for the cases (22.4%, 95% confidence interval [CI] 0.3% to 34.9%) and the control subjects (34.7%, 95% CI 21.2% to 40.1%). Among the survivors, the hospital stay was increased by 19.6 d (95% CI -1.1; 40.4). This represents an added cost of 3,124 Euros per episode of CRI among the survivors. In conclusion, our cohort study failed to show a difference in attributable mortality due to CRI in intensive care unit patients. Nevertheless, these infections lead to an increase in hospital stay of approximately 20 d. Each episode of CRI represents an additional cost of more than 3,000 Euros.
Vitamin B-6 reprieved in UK
Authors: J. Warden
Journal: BMJ (1998)

Dietary supplements of vitamin B-6 have been granted a stay of execution by the British government pending further advice on safety levels. Legislation to control the general sale of dietary supplements containing more than 10 mg of vitamin B-6 per daily dose has been deferred for at least two years.

This follows last week's government changes, when Nick Brown replaced Jack Cunningham as minister …
IMPROVED SURVIVAL AND INCREASE IN BYSTANDER CARDIOPULMONARY RESUSCITATION AFTER OUTOF-HOSPITAL CARDIAC ARREST: A NATIONWIDE COHORT STUDY 2001-2010
Authors: Mads Wissenberg, Fredrik Folke, Peter Weeke, Carolina Malta Hansen, Jonas Olesen, Jesper Lindhardsen, Freddy Lippert, Gunnar Gislason, Soeren L Nielsen, Lars Kober, Christian Torp-Pedersen
Journal: Journal of the American College of Cardiology (2012)
Tolerance of rats to hyperoxia. Lung antioxidant enzyme gene expression.
Authors: L B Clerch, D Massaro
Journal: Journal of Clinical Investigation (1993)

Tolerance to hyperoxia usually requires an increase of lung antioxidant enzyme (AOE) activity. We used rats with different degrees of tolerance to > 95% O2 to evaluate the importance of individual AOEs for tolerance; we also explored the regulation of AOE gene expression. During exposure of adult rats to > 95% O2, lung manganese superoxide dismutase (MnSOD) activity fell approximately 50% despite a threefold increase of MnSOD mRNA concentration; addition of a reducing agent to lung extracts from O2-exposed rats partially restored MnSOD activity. Endotoxin induced tolerance to O2 (a) without elevating Cu,Zn superoxide dismutase activity, (b) with increases of catalase and glutathione peroxidase (GP) activity of the same magnitude as occurred in O2-saline rats, but (c) with MnSOD activity 1.5-1.9-fold higher than in air-saline rats and 1.4-3.6-fold higher than in O2-saline rats. Endotoxin elevated the concentration of MnSOD and GP mRNAs without increasing their stability. O2 elevated MnSOD mRNA concentration, and increased its stability. O2 plus endotoxin increased the concentration and stability of MnSOD, catalase, and GP mRNAs. These data suggest that in adult rats tolerance to hyperoxia requires increased MnSOD activity; the data show gene expression and regulation vary among the AOEs, and that increased stability of the AOEs' mRNAs plays an important role in AOE gene expression and in tolerance to hyperoxia.
The Role of Litigation in Defining Drug Risks
Authors: Aaron S. Kesselheim, Jerry Avorn
Journal: JAMA (2007)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Wertanalyse der therapeutischen Begegnung
Authors: Heinz Häfner
Journal: Psychotherapy and Psychosomatics (1955)

Research Articles| January 20 2010 Wertanalyse der therapeutischen Begegnung Subject Area: Psychiatry and Psychology Heinz Häfner Heinz Häfner München Search for other works by this author on: This Site PubMed Google Scholar Acta Psychotherapeutica et Psychosomatica (1955) 3 (Suppl. 1): 132–139. https://doi.org/10.1159/000278644 Article history Published Online: January 20 2010 Content Tools Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Facebook Twitter LinkedIn Email Tools Icon Tools Get Permissions Cite Icon Cite Search Site Citation Heinz Häfner; Wertanalyse der therapeutischen Begegnung. Acta Psychotherapeutica et Psychosomatica 1 January 1955; 3 (Suppl. 1): 132–139. https://doi.org/10.1159/000278644 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAll JournalsActa Psychotherapeutica et Psychosomatica Search Advanced Search Article PDF first page preview Close Modal This content is only available via PDF. 1955Copyright / Drug Dosage / DisclaimerCopyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher.Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. You do not currently have access to this content.
Select committee castigated for citing death of 3 year old girl in obesity report
Authors: Tom Sanders
Journal: BMJ (2004)

The House of Commons Select Committee's inquiry on obesity was published on 27 May. The press release, issued the previous day but embargoed till publication of the report, highlighted the rapidly rising rates of obesity, the potential health consequences, and the need to increase physical activity and focus on preventing obesity in children. However, Radio 4's Today programme on 26 May had been leaked a story that MPs would report the case of an obese child who died of heart failure. By the evening, the media was saying that the report was critical of both the government and the food industry, and called for the banning of food advertising aimed at children. The following morning, national newspapers carried headlines like “Obesity kills child of 3.”

The report was officially available to the press for the first time on 27 May. Its second paragraph leaps out at the reader: “Over the …
Development of anti‐idiotypic antibodies in a patient with a factor VIII autoantibody
Authors: Cheryl Tiarks, Liberto Pechet, Robert E. Humphreys
Journal: American Journal of Hematology (1989)

Abstract Antibodies against coagulation factor VIII were detected in a 33‐year‐old who developed severe bleeding 2 months postpartum. After treatment with plasmapheresis and immunosuppressive agents, the inhibitor was no longer detectable, but anti‐idiotypic antibodies were detected, as demonstrated by binding in immunoradiometric assays, and by in vitro neutralization of the initial factor VIII autoantibodies. The anti‐idiotypic titer subsequently declined but was still detectable 1 year later. Three commercial immunoglobulin preparations and pooled multiparous IgG also bound to (but did not neutralize) the patient's factor VIII antibody. These studies suggest that anti‐idiotypic antibodies, arising in the face of immunosuppressive therapy, might suppress autoimmunity to factor VIII and confirm the presence of anti‐idiotypic antibodies in pooled normal immunoglobulins.
TCT-448 BIOTRONIK-Safety and Clinical Performance of the Drug Eluting Orsiro Stent in the Treatment of Subjects With Single De Novo Coronary Artery Lesions-II (BIOFLOW-II) – 4 Year Clinical Results
Authors: ton slagboom, Michael Haude, Thierry Lefevre, Salim Hayek, Karl Stangl, Franz-Josef Neumann, Rafaelruiz Salmeron, Manel Sabate, Gert Richardt, Bela Merkely, Javier Goicolea, Johannes Bilger, paul barragan, Ron Waksman, Stephan Windecker
Journal: Journal of the American College of Cardiology (2016)
INDICATIONS FOR STRYCHNIN AND NITROGLYCERIN IN CIRCULATORY DISORDERS.
Authors: ORVILLE HARRY BROWN
Journal: JAMA (1906)

The pharmacologic action of nitroglycerin is erroneously conceived by some physicians. I have heard practitioners remark that "even the use of nitroglycerin and strychnin is ineffectual in causing a weakening circulation to recover." To understand the therapeutic indications for these two drugs in circulatory symptoms, a thorough knowledge of a portion of the physiology of the circulation is absolutely necessary. The heart is a muscular organ which pumps the blood into the aorta at a rate which normally maintains the blood pressure constant, within certain narrow limits. The control of the heart's rate is automatic. The vagus and sympathetic nerves carry impulses to the heart; the former is the inhibitory nerve and the latter the accelerator. A small nerve running in the same sheath as the vagus, called the depressor, is the sensory nerve to the heart. The small blood vessels, the arterioles, have their caliber controlled by the vasomotor
Heparin in pregnant women with previous placenta-mediated pregnancy complications: a prospective, randomized, multicenter, controlled clinical trial
Authors: Ida Martinelli, Piero Ruggenenti, Irene Cetin, Giorgio Pardi, Annalisa Perna, Patrizia Vergani, Barbara Acaia, Fabio Facchinetti, Giovanni Battista La Sala, Maddalena Bozzo, Stefania Rampello, Luca Marozio, Olimpia Diadei, Giulia Gherardi, Sergio Carminati, Giuseppe Remuzzi, Pier Mannuccio Mannucci
Journal: Blood (2012)
Mosaic expression of uncein and 180-kDa bullous pemphigoid antigen in generalized atrophic benign epidermolysis bullosa
Authors: Y. MATSUMURA, Y. HORIGUCHI, K. TODA, H. FUJII, S. KORE-EDA, T. TACHIBANA, K. OHTA, H. OKAMOTO, S. IMAMURA
Journal: British Journal of Dermatology (1997)

Immunofluorescence microscopy of epidermodermal junction components in serial cryosections from the perilesional skin of a patient with generalized atrophic benign epidermolysis bullosa (GABEB) showed broken line‐like staining of both BPAG2 (180‐kDa bullous pemphigoid antigen) and uncein (antigen of 19‐DEJ‐l monoclonal antibody), whereas integrin α6 and laminin 5 were continuously expressed along the basement membrane zone. Immunoelectron microscopy revealed a mosaic distribution of the BPAG2/uncein positive and negative cells. BPAG2, a candidate protein of GABEB, probably has a close connection with uncein, an anchoring filament component.
Locally Advanced Pancreatic Cancer
Authors: Christopher G. Willett, Brian G. Czito, Johanna C. Bendell, David P. Ryan
Journal: Journal of Clinical Oncology (2005)

Of the 32,180 patients diagnosed with pancreatic carcinoma in the United States this year, approximately 40% will present with locally advanced disease. Radiotherapeutic approaches are often employed because these patients have unresectable tumors by virtue of local invasion into the retroperitoneal vessels in the absence of clinically detectable metastases. These treatments include external-beam irradiation with and without fluorouracil-based chemotherapy, intraoperative irradiation, and, more recently, external-beam irradiation with new systemic targeted agents.
Insights into public assistance medical care expenditures
Authors: R. W. Hammel
Journal: JAMA (1972)

Public assistance medical care expenditure data supplied to the US Department of Health, Education, and Welfare by nine Western and ten Southern state were analyzed. For comparison purposes, data from states without a drug formulary or with an open or unrestricted formulary were compared with those from states maintaining a closed formulary. Contrary to popular expectation, no relationship was found between formulary status and expenditures. Broadly based peer review and utilization control programs are suggested as a sounder approach to the efficient provision of medical care.
Normal antenatal management.
Authors: R Pepper, B Wylie
Journal: BMJ (1991)

arrival of the doctor, and the administration of the thrombolytic agent (either at home or in hospital), and I believe that it might well be possible to show important correlations.Drs Radford and Richards, and Dr M S Stead, state, as if it was fact, that anistreplase produces an excess of four in 1000 strokes compared with streptokinase.Is it not remarkable that the major study from which this figure derives, for which the analysis is still incomplete, has been announced to the world and yet not published, and that our information is being received at second hand through the medium of a medical journalist, however distinguished and amusing'?Without being able to see the original data relating to analysis of the whole of the study it is premature to
The Association Between Dietary Patterns at Midlife and Health in Aging
Authors: Cécilia Samieri
Journal: Annals of Internal Medicine (2013)

Maintaining health and well-being in aging populations is critical.To examine the association between dietary patterns in midlife and prevalence of healthy aging.Cross-sectional observational study.Nurses' Health Study.10 670 women with dietary data and no major chronic diseases between 1984 and 1986, when they were in their late 50s and early 60s (median age, 59 years). Women provided information on health an average of 15 years later.Diet quality in midlife was ascertained using the Alternative Healthy Eating Index-2010 (AHEI-2010) and Alternate Mediterranean diet scores, averaged from 2 food-frequency questionnaires (1984 to 1986). "Healthy" aging was defined as survival to 70 years or older with maintenance of 4 health domains: no major chronic diseases or major impairments in cognitive or physical function or mental health.After multivariable adjustment, greater adherence to the AHEI-2010 (upper vs. lower quintiles) in midlife was related to 34% (95% CI, 9% to 66%; P for trend < 0.001) greater odds of healthy versus usual aging. Greater adherence to Alternate Mediterranean diet was related to 46% (CI, 17% to 83%; P for trend = 0.002) greater odds of healthy aging. When the 4 components of healthy aging were analyzed separately, the AHEI-2010 and Alternate Mediterranean diet were significantly associated with greater likelihood of no major limitations in physical function and mental health.Residual confounding was possible, although many confounding factors were considered. Bias due to complex patterns of measurement error within diet scores cannot be excluded.Better diet quality at midlife seems to be strongly linked to greater health and well-being in persons surviving to older ages.National Cancer Institute, National Institutes of Health.
Aggressive Non-Hodgkin's Lymphoma in the Elderly: an Effective, Well Tolerated Treatment Regimen Containing Extended Schedule Etoposide
Authors: W. A. Young, F. A. Greco, J. P. Greer, J. D. Hainsworth
Journal: JNCI Journal of the National Cancer Institute (1994)

Journal Article Aggressive Non-Hodgkin's Lymphoma in the Elderly: an Effective, Well Tolerated Treatment Regimen Containing Extended Schedule Etoposide Get access Wade A. Young, Wade A. Young Division of Oncology, Vanderbilt University, NashvilleTenn Search for other works by this author on: Oxford Academic PubMed Google Scholar F. Anthony Greco, F. Anthony Greco The Sarah Cannon Cancer Center, Centennial Medical CenterNashville. Search for other works by this author on: Oxford Academic PubMed Google Scholar John P. Greer, John P. Greer Division of Oncology, Vanderbilt University, NashvilleTenn Search for other works by this author on: Oxford Academic PubMed Google Scholar John D. Hainsworth John D. Hainsworth * The Sarah Cannon Cancer Center, Centennial Medical CenterNashville. *Correspondence to : John D. Hainsworth, M.D., The Sarah Cannon Cancer Center, Centennial Medical Center, 250 25th Ave. North. Suite 412, The Atrium, Nashville, TN 37203. Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 86, Issue 17, 7 September 1994, Pages 1346–1347, https://doi.org/10.1093/jnci/86.17.1346 Published: 07 September 1994 Article history Received: 04 January 1994 Revision received: 22 April 1994 Accepted: 17 June 1994 Published: 07 September 1994
Femoral Neuropathy and Retroperitoneal Hemorrhage
Authors: Gordon J. Gilbert
Journal: JAMA (1970)

<h3>To the Editor:—</h3> The article by Cianci and Piscatelli (<b>210:</b>1100, 1969) depicts the clinical manifestations of a femoral neurpathy secondary to retroperitoneal hemorrhage. Dr. Roger Laughlin and I reported a similar case (<i>Southern Med J</i><b>60:</b>176, 1967), in which the retroperitoneal hemorrhage was secondary to use of warfarin sodium. It was diagnostically helpful in our case that there was an exquisite sensitivity to palpation over the right femoral nerve at the inguinal ligament. The region just lateral to the femoral artery at the inguinal ligament was a "Tinel's point," and pressure over the femoral nerve reproduced and exacerbated the patient's pain pattern. It is important to palpate the femoral nerve at the inguinal ligament in any patient with femoral neuropathy of sudden onset. Therapeutically, we found that the application of hot packs to the inguinal region provided dramatic relief of the pain. It appears that the prognosis in hemorrhagic
Long-term remission in patients with dermatitis herpetiformis on a normal diet
Authors: M.T. Bardella, C. Fredella, C. Trovato, E. Ermacora, R. Cavalli, V. Saladino, L. Prampolini
Journal: British Journal of Dermatology (2003)

A life-long gluten-free diet is the treatment of choice for dermatitis herpetiformis, which is considered to be coeliac disease of the skin.To investigate the effects on long-term remission of dermatitis herpetiformis in patients who underwent a gluten challenge and subsequently reintroduced dietary gluten.We studied 38 patients (14 male and 24 female) with biopsy-confirmed dermatitis herpetiformis. They had followed a gluten-free diet for a mean of 8 years, achieving clinical remission and intestinal normalization. The patients were asked to reintroduce gluten in their diet and agreed to undergo skin and intestinal biopsies during the follow-up.Of the 38 patients abandoning a gluten-free diet, 31 reported the onset of rash within an average of 2 months. Seven subjects (three males, mean age 15 years at challenge) experienced no clinical or histological relapses (median follow-up 12 years), and lost IgA immunoglobulin from the skin. The two series of patients differed in terms of age at diagnosis (mean age: 26.6 vs. 6 years), the use of dapsone (one of 31 vs. four of seven) and adherence to the gluten-free diet (strict compliance in 26 of 31 vs. none of seven).Our data suggest that the ingestion of small doses of gluten in childhood and/or the use of an anti-inflammatory drug may modify the immunological response inducing immune tolerance. We report long-term clinical and histological remissions in seven patients with dermatitis herpetiformis after the reintroduction of dietary gluten.
REPORT ON THE ADVANCES AND DISCOVERIES MADE IN THE STUDY OF CONTAGIOUS AND INFECTIOUS DISEASES.
Authors: WILLIAM LEE
Journal: JAMA (1884)

Address of the Chairman of the Section on Diseases of Children, May, 1884. Opposed to specialties as they are generally practiced, as many of the best and wisest in our profession are, it must be admitted, nevertheless, that the formation of a Section on Children's Diseases by this Association was eminently proper, for not only has our example been followed by the British Medical Association, as shown at its last meeting, when a similar Section was inaugurated, but in these days, when the question as to division of labor in the science of medicine, as well as in other fields of human labor, is engaging so much attention, Pediatrics must sooner or later be allowed to hold that independent position which it deserves. This fact we are made to appreciate very forcibly through the leaves of the<i>Archives of Pediatrics</i>, lately started in our country, to which I hope each
Letter by Ayalloore and LeLorier Regarding Article, “Relationship Between Nonsustained Ventricular Tachycardia After Non-ST-Elevation Acute Coronary Syndrome and Sudden Cardiac Death: Observations From the Metabolic Efficiency With Ranolazine for Less Ischemia in Non-ST-Elevation Acute Coronary Syndrome-Thrombolysis in Myocardial Infarction 36 (MERLIN-TIMI 36) Randomized Controlled Trial”
Authors: Siby G. Ayalloore, Paul LeLorier
Journal: Circulation (2011)