LIVER FUNCTION STUDIES DURING CORTISONE THERAPY
Authors: J H HOLMES, S C PERCEFULL
Journal: Annals of Internal Medicine (1951)

Article1 September 1951LIVER FUNCTION STUDIES DURING CORTISONE THERAPYJOSEPH H. HOLMES, M.D., F.A.C.P., S. C. PERCEFULL, M.D.JOSEPH H. HOLMES, M.D., F.A.C.P., S. C. PERCEFULL, M.D.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-35-3-608 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe study dealt with herein was undertaken to determine if any of the usual clinical liver function tests change in any way under cortisone therapy. It is well known that the adrenal cortex is concerned with protein,1, 2glucose3and fat4, 5metabolism. It has even been reported that the administration of ACTH will produce a fatty liver in the experimental animal, although this can be prevented by the administration of glucose.4Furthermore, patients with Cushing's syndrome frequently have hypercholesteremia, and patients with adrenal insufficiency tend to a low serum cholesterol.7A marked hypercholesteremia was observed in rabbits after adrenal...Bibliography1. BondyEngelFarrar PKFLB: The metabolism of amino acids and protein in the adrenalectomized-nephrectomized rat, Endocrinology 44: 476-483, 1949. CrossrefMedlineGoogle Scholar2. HartmanBrownell FAKA: The adrenal gland, 1949, Lea and Febiger, Philadelphia. Google Scholar3. YoungAbelsHomburger NFJCF: Studies on carbohydrate metabolism in patients with gastric cancer, defective hepatic glycogenesis; effects of adrenocortical extract, J. Clin. Investigation 27: 760-765, 1948. CrossrefGoogle Scholar4. Levin L: Physical stress and liver fat content of the fasted mouse, Federation Proc. 8: 218-219, 1949. Google Scholar5. LiIngleEvansPrestrudaNezamis CHDJHMMCJE: Effect of adrenocorticotrophic hormone upon liver fat and urinary phosphorus in normal forcefed rat, Proc. Soc. Exper. Biol. and Med. 70: 753-756, 1949. CrossrefMedlineGoogle Scholar6. GoldnerMorse MGM: Studies on serum esterase, J. Lab. and Clin. Med. 34: 858, 1949. MedlineGoogle Scholar7. Selye H: Textbook of endocrinology, 1947, Acta Endocrinologica, Montreal, Canada, p. 145. Google Scholar8. Hoffmeyer J: The influence of adrenal cortex on the cholesterol content in rabbit serum, Acta physiol. Scandinav. 10: 31, 1945. CrossrefGoogle Scholar9. AdlersbergSchaeferDritch DLER: Adrenal cortex and lipid metabolism: effects of cortisone and adrenocorticotropin (ACTH) on serum lipids in man, Proc. Soc. Exper. Biol. and Med. 74: 877, 1950. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Fort Logan, Colorado*Received for publication December 18, 1950.From the Medical Service, Veterans Administration Hospital, Fort Logan, Colorado, and the Department of Medicine, University of Colorado Medical Center.Sponsored by the Veterans Administration and published with approval of the Chief Medical Director. The statements and conclusions published by the authors are the result of their own studies and do not necessarily reflect the opinion or policy of the Veterans Administration.This work is part of a coördinated program for the study of Cortisone conducted by the Research Division of the Veterans Administration. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byThe treatment of chronic hepatitis with adrenal cortical hormonesUnusual Fatal Infectious Complications of Steroid-Treated Liver DiseaseHepatotoxic effect of cortisone in experimental animalsPhysiology of the Adrenal CortexTHE COURSE OF INFECTIOUS HEPATITIS WITH SPECIAL REFERENCE TO PROGNOSIS AND THE CHRONIC STAGEHepatomegaly with Fatty Infiltration Secondary to Cortisone Therapy: Case Report 1 September 1951Volume 35, Issue 3Page: 608-614KeywordsAdrenocorticotropic hormoneFatty liverGlucose metabolismHospital medicineHypercholesterolemiaLiverLiver function testsMedical servicesProtein metabolismRabbits Issue Published: 1 September 1951 PDF downloadLoading ...