Antibiotic Therapy in Tropical Sprue
Authors: FREDERICK A. KLIPSTEIN
Journal: Annals of Internal Medicine (1964)

Case Studies1 October 1964Antibiotic Therapy in Tropical SprueThe Role of Dietary Folic Acid in the Hematologic Remission Associated with Oral Antibiotic TherapyFREDERICK A. KLIPSTEIN, M.D.FREDERICK A. KLIPSTEIN, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-61-4-721 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe initial observations made 20 years ago that treatment with sulfonamide preparations arrested the diarrhea of military personnel in India afflicted with tropical sprue (1-3) have subsequently been confirmed and amplified. Anderson and co-workers (4) and French, Gaddie, and Smith (5) observed a gastrointestinal remission in all of seven British soldiers who had acquired tropical sprue in the Far East and were treated with broad spectrum antibiotics in Birmingham, England. Subsequently, studies of Puerto Rican patients, both in Puerto Rico (6, 7) and in New York City (8), and of Indian subjects in London (9, 10) have confirmed the fact...References1. ROGERS L: The use of Prontosil in sprue. Brit. Med. J. 2: 943, 1938. CrossrefMedlineGoogle Scholar2. KEELEBOUND KDJP: Sprue in India: clinical survey of 600 cases. Brit. Med. J. 1: 77, 1946. CrossrefMedlineGoogle Scholar3. STEFANINI M: Clinical features and pathogenesis of tropical sprue. Medicine 27: 379, 1948. CrossrefMedlineGoogle Scholar4. ANDERSONFRAZERFRENCHHAWKINSROSSSAMMONS CMACJMCFCAHG: The influence of gluten and antibacterial agents on fat absorption in the sprue syndrome. Gastroenterologia (Basel) 81: 98, 1954. CrossrefMedlineGoogle Scholar5. FRENCHGADDIESMITH JMRNM: Tropical sprue: A study of seven cases and their response to chemotherapy. Quart. J. Med. 25: 333, 1956. MedlineGoogle Scholar6. SHEEHYPEREZ-SANTIAGO TWE: Antibiotic therapy in tropical sprue. Gastroenterology 41: 208, 1961. 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CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: New York, New YorkFrom the Department of Medicine, College of Physicians and Surgeons, Columbia University, and the Medical Service of the Francis Delafield Hospital, New York City, N. Y.This work was supported in part by grant CA-02332 from the United States Public Health Service, Bethesda, Md., and fellowship ACF 25b from the American Cancer Society.Requests for reprints should be addressed to Frederick A. Klipstein, M.D., Francis Delafield Hospital, 99 Ft. Washington Ave., New York, N. Y. 10032. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byIdiopathic Small Intestinal Disease in the TropicsTropical EnteropathyFolate in Tropical SprueTropische Enteropathie und tropische SpruePoorly Absorbed Sulfonamides in the Treatment of Tropical SprueCurrent Views on Tropical Sprue and a Comparison to Nontropical SprueTropical SprueFolates in Human NutritionFolates in Human NutritionFolate Repletion Associated with Oral Tetracycline Therapy in Tropical SprueTropical Sprue in HaitiFREDERICK A. KLIPSTEIN, M.D., I. MICHAEL SAMLOFF, M.D., ERIC A. SCHENK, M.D. 1 October 1964Volume 61, Issue 4Page: 721-728KeywordsAntibioticsAttentionFolic acidHispanic peopleHospital medicineMedical servicesMegaloblastic anemiaPatientsSulfonamideSurgeons Issue Published: 1 October 1964 PDF downloadLoading ...