tbuckley/cabot-search huggingface dataset:
Shades of Scheherazade in a Feat of Superfecundation
Authors: Samuel Vaisrub
Journal: JAMA (1979)

It is not often that a shady old joke partakes of prophecy. Such is the tale of two swains and the girl whose favors they enjoyed in equal measure. On learning that the girl became pregnant, the two gallants, not being sure of who the father was, agreed to equal partnership in supporting the expected child. On the day of delivery, however, a surprising telegram arrived from one of the partners to the other, who happened to be out of town. The message read: "Toots gave birth to twins. Mine died." This joke will provoke little laughter now after we have read the report by Terasaki et al<sup>1</sup>on twins with two different fathers identified by HLA typing. In fact, some of the punch had gone out of the joke much earlier when Archer<sup>2</sup>reported in 1810 the birth of twins, one of whom was white, the other
Does Microalbuminuria Predict Diabetic Nephropathy?
Authors: Bahman P. Tabaei, Abdul S. Al-Kassab, Liza L. Ilag, Catherine M. Zawacki, William H. Herman
Journal: Diabetes Care (2001)

OBJECTIVE—To describe risk factors associated with microalbuminuria (MA) in subjects with diabetes, investigate the predictive value of MA as a marker of risk for diabetic nephropathy (DN), and define risk factors associated with the development and progression of MA. RESEARCH DESIGN AND METHODS—We conducted a prospective longitudinal study of 23 diabetic subjects with persistent MA and 209 diabetic subjects without MA who attended diabetes clinics at the University of Michigan Medical Center in 1989 and 1990. Both groups were examined at baseline and after 7 years. At baseline, urinary albumin–to–creatinine ratios were studied in random, first morning, and 24-h urine samples. At follow-up, a 12-h overnight urine sample was collected and analyzed for albumin and creatinine. At baseline, MA was defined by at least two separate urine specimens with albumin–to–creatinine ratios between 30 and 299 μg albumin per milligram of creatinine. RESULTS—MA regressed in 56% of subjects with baseline MA without systematic application of corrective measures and developed in 16% of subjects without baseline MA. The predictive value positive of MA as a marker of risk for DN was 43%, and the predictive value negative was 77%. In the combined cohort, the incidence and progression of MA were significantly associated with poor glycemic control and duration of diabetes between 10 and 14 years. CONCLUSIONS—MA may not be as sensitive and specific a predictor of DN as previously suggested. Other markers of risk for DN are needed for optimal clinical management.
Cytotoxic-lnduced Ovarian Failure in Women With Hodgkin's Disease
Authors: Ramona M. Chapman
Journal: JAMA (1979)

Forty-one women with advanced Hodgkin's disease were studied to determine the effect of combination chemotherapy on fertility and ovarian function. Histories and pretreatment ovarian biopsy specimens indicated normal fertility before therapy, thus implying no adverse effect of Hodgkin's diseases on female gonadal function. Ovarian activity was assessed after therapy by menstrual history, serial basal body temperatures, and hormonal levels. Each case was assigned to one of three categories: primary ovarian failure (failed ovary), irregular ovarian activity (failing ovary), and normal cyclic ovarian activity (functioning ovary). After therapy, 20 of 41 patients (49%) were categorized as failed, 14 (34%) as failing, and only 7 (17%) as functioning. In 16 months of further observation, progressive loss of ovarian function occurred that was clearly age related but not statistically dose related. Induction of premature, irreversible menopause presents a need for effective hormonal replacement and patient counseling.
The relationships between serum alt levels, virological characteristics, and liver histology in patients with chronic hepatitis C: Clinical implications of immunopathogenesis of HCV
Authors: S.K. Yoon, B.H. Byun, E.S. Chung, Y.M. Park, T.W. Park, J.M. Yang, B.M. Ahn, Y.S. Lee, K.W. Chung, H.S. Sun, B.K. Kim, B.S. Kim
Journal: Journal of Hepatology (2000)
The Value of Colonoscopy and Ultrasonography in the Diagnosis of Chronic Intussusception in Childhood
Authors: G. Maurer, P. Kratochvil, G. Brandstätter
Journal: Endoscopy (1986)

Ultrasonography and colonoscopy were diagnostic for chronic intussusception in a 6-year-old girl. After an episode of acute gastroenteritis the child developed non-specific recurrent abdominal symptoms, which were considered to be functional. While the ultrasonographic pattern alone was too unspecific to establish the correct diagnosis, the colonoscopic findings were diagnostic of intussusception.
Influence of reflow ventricular fibrillation and electrical defibrillation on infarct size in a canine preparation of myocardial infarction
Authors: M. d. Lorgeril, A. Basmadjian, R. Clement, G. Rousseau, J.-G. Latour
Journal: Cardiovascular Research (1990)

Study objective – The aim of the study was to investigate the influence of reflow ventricular fibrillation and electrical defibrillation on infarct size in a model of myocardial ischaemia. Design – Myocardial ischaemia was induced in an open chest canine model by occluding the left coronary artery for 2 h. This was followed by 6 h reperfusion. The influence of reflow fibrillation and internal electric defibrillation on infarct size was investigated and compared to dogs which did not develop fibrillation. Infarct size and its major determinants, rate-pressure product (RPP), area at risk (AR), and collateral flow (MBF), were measured and their relationships studied in the two situations, using uni- and multilinear regression analysis. Subjects – 21 adult mongrel dogs of either sex were used in the studies, which were done under pentobarbitone anaesthesia. Two were excluded because they developed ventricular fibrillation soon after coronary occlusion, and one did not survive reflow ventricular fibrillation. Of the remaining 18 dogs, six developed reflow ventricular fibrillation and were compared to the control group of 12 which did not develop fibrillation. Measurements and results – A mean of 70.8(SEM 18.7) joules was required to revive the six dogs with reflow ventricular fibrillation. Difference in mean infarct size in the two groups did not reach significance [49.1(4.4) in fibrillation group v 38(6.2) in the controls]. The multiple linear regression model in the control group accounted for 91% of the variation in infarct size (IS): IS = −3.4 + 0.49 (AR) − 21.8 (MBF) + 0.025 (RPP). The equation was not modified by including the reflow fibrillation dogs: IS = −3.1 + 0.52 (AR) − 19 (MBF) + 0.02 (RPP). Ischaemic determinants of infarct size in the reflow fibrillation dogs were computed in the control group equation to compare the infarct size predicted by the model to the measured infarct size in each individual dog in the reflow fibrillation group. There was no significant difference between the means: 12.9(2.9)% (predicted) v 14.9(2.5)% (measured). Conclusions – In this model of myocardial infarction, reflow ventricular fibrillation and low energy internal electric shocks do not damage the myocardium at risk significantly.
PSEUDO-MEMBRANOUS ENTERITIS ASSOCIATED WITH ASCARES LUMBRICOIDES.
Authors: IRVING M. SNOW
Journal: JAMA (1895)

<h3>(SYNOPSIS.)</h3> This case of pseudo-membranous enteritis occurred in a girl of 2½ years. During the summer of 1894 she suffered from a severe attack of whooping cough, followed by ileo-colitis lasting six weeks. In the most acute stage of the diarrhea she began to pass pieces of membrane and tubular casts of the bowels; six weeks later, the membranes being daily present in the feces, several round worms were evacuated, after which no more membrane appeared in the stools for four and one-half months, when, coincident with an attack of grippe-bronchitis, bits of membrane and two ascarides were passed for two days. No recurrence of the membrane casts since. On Sept. 27, 1894, a little German girl aged 2½ years was brought to me with the following history: father dead of sarcoma of the rectum, mother and one sister living. The patient was born after a normal labor and reared
Contingent Fees and Malpractice
Authors: Peter Van Zante
Journal: JAMA (1971)

<h3>To the Editor.—</h3> Many maintain that the contingent fee is the major factor in promoting malpractice suits under our present state laws as it favors an unscrupulous plaintiff over an innocent defendant. An innocent successful defendant in a malpractice suit still has to pay his own attorney's fee. Isn't this legalized extortion, when you are innocent and proved innocent by the court? We must change our state laws so that they will require the plaintiff, if he loses his case in the court, to not only pay court costs but also a reasonable fee to the winning party's attorney. Such a proposed change in our state laws, on the other hand, would also be beneficial to a plaintiff who had a just reason for a malpractice suit, for in his successful court action the guilty defendant would not only pay court costs but also the attorney's fee of the plaintiff.
Frequency versus time domain analysis of signal-averaged electrocardiograms. II. Identification of patients with ventricular tachycardia after myocardial infarction
Authors: Piotr Kulakowski, Marek Malik, Jan Poloniecki, Yaver Bashir, Olusola Odemuyiwa, Thomas Farrell, Anne Staunton, John Camm
Journal: Journal of the American College of Cardiology (1992)
Leukemia Among Participants in Military Maneuvers at a Nuclear Bomb Test
Authors: Glyn G. Caldwell
Journal: JAMA (1980)

Preliminary studies indicate that nine cases of leukemia have occurred among 3,224 men who participated in military maneuvers during the 1957 nuclear test explosion "Smoky." This represents a significant increase over the expected incidence of 3.5 cases. They included four cases of acute myelocytic leukemia, three of chronic myelocytic leukemia, and one each of hairy cell and acute lymphocytic leukemia. At time of diagnosis, patient ages ranged from 21 to 60 years (mean, 41.8 years) and the interval from time of nuclear test to diagnosis from two to 19 years (mean, 14.2 years). Film-badge records, which are available for eight of the nine men, indicated gamma radiation exposure levels ranging from 0 to 2,977 mrem (mean, 1,033 mrem). Mean film-badge gamma dose for the entire Smoky cohort was 466.2 mrem.
BIVALIRUDIN VS. UNFRACTIONATED HEPARIN IN PATIENTS UNDERGOING STENTING OF SAPHENOUS VEIN GRAFTS. AN ANALYSIS FROM THE EVENT REGISTRY
Authors: Radwane Kesserwane, Neal Kleiman, Michelle Keyes, Michael Pencina, Ali Sonel, Faisal Latif, Mazen Abu-Fadel, David Cohen, Jorge F. Saucedo
Journal: Journal of the American College of Cardiology (2010)
The Effects of Fasting and Feeding on Preproinsulin Messenger RNA in Rats
Authors: Stephen J. Giddings, John Chirgwin, M. Alan Permutt
Journal: Journal of Clinical Investigation (1981)

The purpose of these experiments was to determine whether alterations in preproinsulin messenger (m)RNA activity could account for changes in insulin biosynthesis during fasting and refeeding. Rats were fasted 4 d and then fed for 6, 8, 24, or 48 h. With fasting, body weight decreased 25%, plasma glucose decreased from 6.1 to 2.2 mM, and pancreatic insulin content fell to 40% that of fed animals. Islet RNA decreased to 50% and protein to 55% that of control animals, while islet DNA content remained unchanged. After 6 h of refeeding, islet RNA content increased and was not significantly different from controls.
Complement in thrombotic thrombocytopenic purpura
Authors: M. Bernadette Garvey, John Freedman
Journal: American Journal of Hematology (1983)

Abstract This report describes a patient with recurrent thrombotic thrombocytopenic purpura (TTP)in whom complement activation was observed during the acute episodes. Serum C3, C4, and CH 50 were reduced, and there was deposition of C3 on red cells and platelets. These findings returned to normal during clinical remission.
Amiodarone and Ventricular Tachycardia
Authors: JANET M. MCCOMB
Journal: Annals of Internal Medicine (1983)

Letters and Corrections1 May 1983Amiodarone and Ventricular TachycardiaJANET M. MCCOMB, M.D., MAZHER M. KHAN, M.B., JOHN S. GEDDES, M.D.JANET M. MCCOMB, M.D.Search for more papers by this author, MAZHER M. KHAN, M.B.Search for more papers by this author, JOHN S. GEDDES, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-98-5-670_2 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: We read with interest the case of amiodarone-induced ventricular tachycardia reported by Westveer and associates (1). They state that amiodarone has previously only been described as a cause of ventricular tachycardia when used in combination with disopyramide. We would like to draw their attention to two reported cases. Veglia and associates (2) described a patient who had torsade de pointes and ventricular fibrillation while taking amiodarone. We have also reported a patient who developed torsade de pointes and ventricular fibrillation after 28 days of treatment with amiodarone(s). This patient was taking no other antiarrhythmic drugs at that...References1. WESTVEERGADOWSKIGORDONTIMMIS DGSG. Amiodarone-induced ventricular tachycardia. Ann Intern Med. 1982;97:561-2. LinkGoogle Scholar2. VEGLIASCANDIFFIOGUERRICCHIO LTG. "Torsioni di punta" e amiodarone. G Ital Cardiol. 1978;8:1025-9. MedlineGoogle Scholar3. MCCOMBLOGANKHANGEDDESADGEY JKMJA. Amiodarone-induced ventricular fibrillation. Eur J Cardiol. 1980;11:381-5. MedlineGoogle Scholar4. VELEZPATRICK RD. Citation of foreign literature in U.S. and U.K. journals [Letter]. N Engl J Med. 1982;307:1155. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Royal Victoria Hospital Belfast BT12 6BA, Ireland. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 May 1983Volume 98, Issue 5_Part_1Page: 670-670KeywordsDrugsVentricular fibrillationVentricular tachycardia Issue Published: 1 May 1983 PDF DownloadLoading ...
THE FINDING OF ACID-FAST BACILLI IN THE CIRCULATING BLOOD
Authors: J. B. Rogers
Journal: JAMA (1913)

That tubercle bacilli occur in the blood-stream in advanced stages and miliary forms of tuberculosis has long been an established fact. The theory that tuberculosis is primarily a bacteriemia dates back to the work of Rosenberger,<sup>1</sup>who claimed to have found tubercle bacilli in the blood-stream in all cases of tuberculosis; this he demonstrated in tuberculous pharyngitis, laryngitis, lupus, bone and pulmonary tuberculosis, and other forms. His work was confirmed by Forseyth,<sup>2</sup>Petty and Mendenhall<sup>3</sup>and others. Brem<sup>4</sup>cast doubt on Rosenberger's findings by reporting the finding of acid-fast bacilli in distilled water. These he called<i>Bacillus citratis</i>and they were supposed to be identical with the acid-fast bacilli found by Rosenberger. Recently Kurashigi<sup>5</sup>using the Kurashigi-Schnitter method, reported finding tubercle bacilli in all cases of tuberculosis, using controls in all tests. This work has been confirmed by Kennerknecht and other German investigators. <h3>The Kurashigi-Schnitter</h3>
pH-dependent, thermosensitive polymeric nanocarriers for drug delivery to solid tumors
Authors: Ching Yi Chen, Tae Hee Kim, Wen Chung Wu, Chi Ming Huang, Hua Wei, Christopher W. Mount, Yanqing Tian, Sei Hum Jang, Suzie H. Pun, Alex K Y Jen
Journal: Biomaterials (2013)
A targeting ligand enhances infectivity and cytotoxicity of an oncolytic adenovirus in human pancreatic cancer tissues
Authors: Yuki Yamamoto, Nobuyoshi Hiraoka, Naoko Goto, Yosei Rin, Kazuki Miura, Kenta Narumi, Hiroaki Uchida, Masatoshi Tagawa, Kazunori Aoki
Journal: Journal of Controlled Release (2014)
GRANULOCYTE-COLONY STIMULATING FACTOR IN ANGINA PATIENTS WITH ISCHAEMIC HEART DIESASE TO STIMULATE NEOVASCULARISATION (GAIN II TRIAL)
Authors: Sharon S. Chih, Peter Macdonald, Jane A. McCrohon, David Ma, Moore John, Matthew Law, Michael P. Feneley, Andrea Herbert, Jason C. Kovacic, Robert M. Graham, None Victor Chang Cardiac Research Institute
Journal: Journal of the American College of Cardiology (2010)
Abstract 1296: Involvement of RSK2 in human skin cancer.
Authors: Cheol-Jung Lee, Hye Suk Lee, Ji-Young Lee, Yong Yeon Cho
Journal: Cancer Research (2013)

Abstract Our previous study demonstrated that the total p90 ribosomal S6 kinase 2 (RSK2) protein level was significantly higher in human skin cancer tissues and cancer cells compared with normal skin tissues and premalignant cell lines. However, the role of RSK2 activation and signaling in human skin cancer has not yet been fully elucidated. In this study, we provided evidences that RSK2 plays a key role in human skin cancer. We examined the effect of knocking down RSK2 expression on EGF-induced anchorage-independent transformation in the premalignant HaCaT human skin keratinocyte cell line and on soft agar colony growth of SK-MEL-28 malignant melanoma (MM) cells. We found that UVB stimulation induced increased in not only the total and phosphorylated protein levels of ERKs and RSK2, but also the nuclear localization and gene expression of RSK2. Moreover, RSK2−/− mouse embryonic fibroblasts (MEFs) showed enhanced sub-G1 accumulation induced by UVB stimulation compared with RSK2+/+ MEFs, indicating that RSK2 might play an important role in tolerance against stress associated with UV. RSK2 knockdown inhibited proliferation and anchorage-independent transformation of HaCaT cells and soft agar colony growth of MM cells. We found that the phosphorylated protein levels of RSK2 were enhanced in cancer tissues compared with normal tissues in a human skin cancer tissue array. Importantly, activated RSK2 protein levels were highly abundant in human skin cancer tissues compared with matched skin normal tissues. Taken together, our results demonstrated that RSK2 plays a key role in neoplastic transformation of human skin cells and in skin cancer growth. Citation Format: Cheol-Jung Lee, Hye Suk Lee, Ji-Young Lee, Yong Yeon Cho. Involvement of RSK2 in human skin cancer. [abstract]. In: Proceedings of the 104th Annual Meeting of the American Association for Cancer Research; 2013 Apr 6-10; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2013;73(8 Suppl):Abstract nr 1296. doi:10.1158/1538-7445.AM2013-1296
Influence of serum luteinising hormone concentrations on ovulation, conception, and early pregnancy loss in polycystic ovary syndrome.
Authors: R. Homburg, N. A. Armar, A. Eshel, J. Adams, H. S. Jacobs
Journal: BMJ (1988)

The empirical observation is well documented that currency exposure can add risk to an unhedged international equity portfolio. Extending that work, this article uses three manipulations of the standard portfolio risk equation to show (1) why currency acts as implicit leverage in a portfolio and can therefore increase risk, even under the assumption of zero correlation; (2) how, under an additional assumption, the portfolio risk equation reduces to the Pythagorean equation and that, by using that result, a simple proof can show that an unhedged international equity portfolio is always riskier than a hedged one; and (3) how the risk equation can be rearranged to give the "correlation breakeven" that an investor requires to be indifferent to hedging (or not hedging). <b>TOPICS:</b>Currency, developed markets, portfolio construction, risk management
Treatment of allergic inflammation and hyperresponsiveness by a simple compound, Bavachinin, isolated from Chinese herbs
Authors: Xi Chen, Ti Wen, Jun Wei, Zhenzhou Wu, Puyue Wang, Zhangyong Hong, Liqing Zhao, Bin Wang, Richard Flavell, Shumei Gao, Min Wang, Zhinan Yin
Journal: Cellular and Molecular Immunology (2013)
Additional Considerations to Precede Selection of Enoxaparin Therapy—Reply
Authors: Douglas D. DeCarolis, Gerhard J. Johnson
Journal: JAMA Internal Medicine (2013)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Internal Medicine HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Internal Medicine journal
LEFT VENTRICULAR TRANSMURAL MECHANICS IN ST-SEGMENT ELEVATION MYOCARDIAL INFARCTION FOLLOWING PRIMARY PERCUTANEOUS CORONARY INTERVENTION
Authors: Giuseppe Caracciolo, Mackram Eleid, Nisha Bhatia, David F. Fortuin, Susan Wilansky, Scipione Carerj, Jagat Narula, Bijoy Khandheria, Partho P. Sengupta
Journal: Journal of the American College of Cardiology (2010)
The Diary of William Harvey: The Imaginary Journal of the Physician Who Revolutionized Medicine
Authors: Stephen R. Ell
Journal: JAMA (1993)

By coincidence, I had just reread Marquerite Yourcenar's<i>Memoires d'Hadrien</i>(widely available in English as<i>The Memoirs of Hadrian</i>), when I began reading this book. The contrast between the two, which are examples of the same genre of what might be termed pseudomemoirs, is instructive. Yourcenar's work brings to life an age, and a complex, eminently human, but transcendently remarkable man. The late Dr Hamburger's book, on the other hand, is anachronistic in its use of language and in the views it ascribes to its subject. Further, Harvey emerges from this book at best a pompous, repetitious, and ultimately boring man, who typifies little if anything of his own time, but rather is almost entirely of the 20th century. It is amazing that, in a book in which medicine plays a highly peripheral role, Yourcenar's Hadrian has much more profound comments on medicine than does Hamburger's Harvey. In form, the
Does anyone understand the government's plan for the NHS?
Authors: M. McKee
Journal: BMJ (2012)

I was not looking forward to January. Each year I teach a course on health systems. My students are among the brightest and best of their generation. They come to London each year from more than 100 countries in a search for enlightenment about health and health policy. Last year the hot topic for discussion was the reorganisation of the US health system, led by President Obama. Although it required a few days of intensive reading, it was not difficult to explain. The justification for change was clear. There was a health system that was the most expensive in the world yet left over 40 million US residents without cover, and which, as we had shown in our research on avoidable mortality ( Health Affairs 2008;27:58-71), was making almost no progress in improving health outcomes. The proposals were relatively straightforward to understand. It was essentially what is called “pay or play,” whereby any person not covered by an employer sponsored health plan or other public insurance must purchase health coverage or be penalised financially. It had a number of weaknesses, such as a failure to cover undocumented migrants and inadequate mechanisms for cost control, but these could be understood given the complex, but clearly defined, legislative process that had to be navigated through …