Resistance of Herpes Simplex to Acyclovir
Authors: HENRY H. BALFOUR
Journal: Annals of Internal Medicine (1983)

Editorials1 March 1983Resistance of Herpes Simplex to AcyclovirHENRY H. BALFOUR JR., M.D.HENRY H. BALFOUR JR., M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-98-3-404 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptClinical trials have shown that intravenous acyclovir is effective for prophylaxis and treatment of mucocutaneous herpes simplex virus infections in immunocompromised patients (1-3) and for treatment of primary genital herpes in otherwise normal adults (4). Acyclovir ointment has been found effective for initial episodes of genital herpes and for mucocutaneous herpes infections in immunocompromised patients (5, 6). Because of its relatively low toxicity, acyclovir will be prescribed widely for herpes simplex infections. Now is the time to address the potential problem of drug resistance in order to devise an appropriate strategy for drug use that will benefit the most patients....References1. MITCHELLBEANGENTRYGROTHBOENBALFOUR CBSKJH. Acyclovir therapy for mucocutaneous herpes simplex infections in immunocompromised patients. Lancet. 1981;1:1389-92. CrossrefMedlineGoogle Scholar2. SARALBURNSLASKINSANTOSLIETMAN RWOGP. Acyclovir prophylaxis of herpes-simplex-virus infections: a randomized, double-blind, controlled trial in bone-marrow-transplant recipients. N Engl J Med. 1981;305:63-7. CrossrefMedlineGoogle Scholar3. WADENEWTONMCLARENFLOURNOYKEENEYMEYERS JBCNRJ Intravenous acyclovir to treat mucocutaneous herpes simplex virus infection after marrow transplantation: a double-blind trial. Ann Intern Med. 1982;96:265-9. LinkGoogle Scholar4. MINDELADLERSUTHERLANDFIDDIAN AMSA. Intravenous acyclovir treatment for primary genital herpes. Lancet. 1982;1:697-700. CrossrefMedlineGoogle Scholar5. 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