tbuckley/cabot-search huggingface dataset:
Long-Term Outcomes of Endoscopic Vein Harvesting After Coronary Artery Bypass Grafting
Authors: Lawrence J. Dacey, John H. Braxton, Robert S. Kramer, Joseph D. Schmoker, David C. Charlesworth, Robert E. Helm, Carmine Frumiento, Gerald L. Sardella, Robert A. Clough, Stephan R. Jones, David J. Malenka, Elaine M. Olmstead, Cathy S. Ross, Gerald T. O'Connor, Donald S. Likosky
Journal: Circulation (2011)

Background— Use of endoscopic saphenous vein harvesting has developed into a routine surgical approach at many cardiothoracic surgical centers. The association between this technique and long-term morbidity and mortality has recently been called into question. The present report describes the use of open versus endoscopic vein harvesting and risk of mortality and repeat revascularization in northern New England during a time period (2001 to 2004) in which both techniques were being performed. Methods and Results— From 2001 to 2004, 8542 patients underwent isolated coronary artery bypass grafting procedures, 52.5% with endoscopic vein harvesting. Surgical discretion dictated the vein harvest approach. The main outcomes were death and repeat revascularization (percutaneous coronary intervention or coronary artery bypass grafting) within 4 years of the index admission. The use of endoscopic vein harvesting increased from 34% in 2001 to 75% in 2004. In general, patients undergoing endoscopic vein harvesting had greater disease burden. Endoscopic vein harvesting was associated with an increased adjusted risk of bleeding requiring a return to the operating room (2.4 versus 1.7; P =0.03) but a decreased risk of leg wound infections (0.2 versus 1.1; P &lt;0.001). Use of endoscopic vein harvesting was associated with a significant reduction in long-term mortality (adjusted hazard ratio, 0.74; 95% confidence interval, 0.60 to 0.92) but a nonsignificant increased risk of repeat revascularization (adjusted hazard ratio, 1.29; 95% confidence interval, 0.96 to 1.74). Similar results were obtained in propensity-stratified analysis. Conclusions— During 2001 to 2004 in northern New England, the use of endoscopic vein harvesting was not associated with harm. There was a nonsignificant increase in repeat revascularization, and survival was not decreased.
Responses of the heart to stimulation of aortic body chemoreceptors in dogs.
Authors: F Karim, R Hainsworth, O A Sofola, L M Wood
Journal: Circulation Research (1980)

We stimulated the aortic chemoreceptors in dogs that were anesthetized with chloralose and artificially ventilated by perfusing the isolated aortic arch with venous blood. Inotropic responses were determined by measuring the maximum rate of change of left ventricular pressure (dP/dt max) with aortic pressure and heart rate held constant. Stimulation of the aortic chemoreceptors resulted in an average increase in heart rate of 14 +/- 2.0 beats/min (mean +/- SE) from 166 +/- 7.7 beats/min and an increase in dP/dt max of 501 +/- 85 mm Hg/sec from 3508 +/- 154 mm Hg/sec. These changes were statistically significant (P less than 0.001). The afferent pathway of the reflex was shown to be in the vagus nerves and the efferent pathway in the cardiac sympathetic nerves. In some of the dogs, the carotid chemoreceptors were also stimulated. This resulted in decreases in heart rate and dP/dt max of 48 +/- 24 beats/min and 795 +/- 142 mm Hg/sec. Thus we have shown that stimulation of aortic chemoreceptors evokes chronotropic and inotropic responses opposite to those evoked from stimulation of carotid chemoreceptors.
Abstract P1-01-13: Intraoperative evaluation of sentinel lymph nodes using touch imprint cytology in patients with early-stage breast cancer: A series of 4367 procedures
Authors: Y Chen, J Chen, J Chen, B Yang, L Li, X Huang, Z Shao, Z Shen, J Wu
Journal: Cancer Research (2013)

Abstract Background: As the screening for breast cancer becomes common in China, an increasing number of early-stage breast cancer has been detected. For those patients, especially the ones with cliniaclly negetive lymph nodes, sentinel lymph node biopsy (SLNB) plays an important role in the assessment of the axillary status, while minimizing the mobidity of axillary lymph node dissection(ALND). Accurate intraoperative assessment of SLN metastases enables the selection of patients for ALND during the same operation. Touch imprint cytology (TIC) serves as a main intraoperative evaluation of SLNs in our institute since Feb-2005. The purpose of this study is to evaluate its clinical value. Methods: Early-stage breast cancer patients treated in our institute between Feb-2005 and Apr-2013 enrolled in this study. To avoid breast tissue contamination, all patients had an intraoperative SLNB performed before undergoing lumpectomy or mastectomy. The fresh SLNs were sectioned into 1.5-3.0mm pieces along the short axis, TIC was performed on both surfaces of each piece, its result was correlated with the histological assessments with Hematoxylin-Eosin (H&amp;E) staining, which considered as the gold standard. Results: A total of 4,367 early-stage breast cancer patients enrolled in the study, and 14,112 SLNs were successfully harvested. Among those, 917 (21.0%) patients were confirmed to have at least one SLN positive for metastases, and 1343 (9.5%) positive SLNs were removed. Based on the final H&amp;E report, the sensitivity, specificity and overall accuracy of TIC was 71.4%, 99.2% and 93.6%, respectively on a per patient basis, and 69.6%, 99.5% and 96.6%, respectively on a per node basis. The sensitivity for macrometastasis and micrometastasis was 74.8% and 26.5%, respectively on a per patient basis, and 78.9% and 25.2%, respectively on a per node basis. To discuss the influence of error results on the surgery procedure, we further reviewed the detail medical records of the patients enrolled in the recent 3 years. Of all the 3290 patiens treated between Jun-2010 and Apr-2013, 207(6.5%) patients needed a second opereation to have the ALN dissected. Meanwhile, 20(0.6%) patients had undergone extra ALND because of the false positive results of TIC. Conclusion: The sensitivity of TIC seems a little lower then the ones reported previously, but the overall accuracy still remains acceptable. In addition, only 7.1% patients were influenced by the error results of TIC, along with the advantages, such as the shorter preparation time and the less cost of cytological specimens, we consider TIC a feasible method, and believe it can serve well in the intraoperative evaluation of SLNs for early-stage breast cancer patients. Citation Information: Cancer Res 2013;73(24 Suppl): Abstract nr P1-01-13.
The French Version of the Defense Style Questionnaire
Authors: Ch. Bonsack, J.N. Despland, J. Spagnoli
Journal: Psychotherapy and Psychosomatics (1998)

&lt;b&gt;Background:&lt;/b&gt; Bond et al. developed the Defense Style Questionnaire (DSQ), a self-questionnaire that aims at empirically measuring conscious derivatives of defense mechanisms. The original analysis yielded 4 factors called Defense Styles (DS). DSQ discriminates between mature and immature defense styles. &lt;b&gt;Objectives:&lt;/b&gt; Determine if the French version of DSQ has (a) face validity, (b) a similar structure to the original version, (c) internal consistency, (d) grouping of defense mechanisms into clinically pertinent defense styles, (e) evidence of nonpatients using more mature defense styles, (f) correlation with Defensive Functioning Scale (DFS) (DSM-IV) [&lt;citeref rid="ref002"&gt;2&lt;/citeref&gt;]. &lt;b&gt;Methods:&lt;/b&gt; Reliability and validity study on 82 control subjects and 140 patients, 59 among them evaluated for defensive level. &lt;b&gt;Results:&lt;/b&gt; Factor analysis of controls sample yielded 4 factors ranging from immature to mature defense styles. DSQ scores on factor I (maladaptive style) are significantly higher in outpatients than in controls. Maladaptive style score correlates with clinical evaluation of defensive level of functioning (DFS). &lt;b&gt;Conclusion:&lt;/b&gt; Psychometric features of the French version are similar to the original scale, although minor differences in individual defense mechanisms are present. Factor I (maladaptive defense style) remains more stable than other factors, accounts for most of variance contribution, has high internal consistency and applies to behaviors, i.e. conscious derivatives of defense mechanisms that can be easily identified. The French version of DSQ is (a) an easy and economical way to rate immature defense style in populations of ‘neurotic’ and borderline patients and (b) further provides a hierarchical grouping of defense mechanisms in defense styles.
MINOR RESPIRATORY ILLNESSES CAUSED BY AN AGENT OF THE PSITTACOSIS/ LYMPHOGRANULOMA-VENEREUM GROUP
Authors: P.K. Fraser, L.A. Hatch, L.G.H. Le Clercq, G.N. Shell, D.W. Pratt, JILLM. Forster, M. Wainwright
Journal: The Lancet (1964)
Lithium, manic-depressive illness, and psychological test performance.
Authors: R J Kerry, J E Orme
Journal: BMJ (1979)

Lithium, manic-depressive illness, and psychological test performance For over 10 years patients responding to treatment at a lithium clinic' have been free from psychiatric symptoms.Little is known about the psychological performance of such patients, but a report,2 using the Minnesota Multiphasic Personality Inventory (MMPI), confirmed that lithium produces a response in depression.Clinical impressions agree that lithium responders are patients with typical manic-depressive illness.3It is still not known how well patients are when taking lithium.
Erythrocyte uroporphyrinogen decarboxylase activity in 80 unrelated patients with porphyria cutanea tarda
Authors: F. KOSZO, M. MORVAY, A. DOBOZY, N. SIMON
Journal: British Journal of Dermatology (1992)

To estimate the prevalence of the subgroups of porphyria cutanea tarda (PCT), erythrocyte uroporphyrinogen decarboxylase (UD) activity was measured in 80 unrelated patients with PCT, and in 45 of their relatives by using pentacarboxyl-porphyrinogen III as substrate. The subgroups were differentiated by analysis of the urinary porphyrins of the patients and 119 of their relatives. Of the patients, 77.5% were found to be suffering from the sporadic form of PCT (type I PCT), and 22.5% from the familial form (type II PCT). Every patient with PCT had previously been affected by alcohol, oestrogen or some other liver-damaging factor. The relative frequency of familial PCT was higher in females (nine of 15) than in males (nine of 65), which suggests that inheritance of the gene for type II PCT may predispose to oestrogen-precipitated PCT. The onset of type II PCT occurred at a lower age than that of type I (42.6 vs. 47.0 years). The findings suggest an increased risk of precipitating factors in carriers of an inherited UD deficiency.
GPs must provide more psychological treatments, Welsh report says
Authors: R. Dobson
Journal: BMJ (2001)

A new mental health strategy for Wales, designed to improve services at all levels, has been launched by the Welsh Assembly.

The strategy, whose aims include tailoring treatment to individual needs and removing the stigma surrounding mental illness, says that GPs need to be aware of the range of services and the way to access them.

“This strategy presents an opportunity to fundamentally change the day-to-day experience of people with mental health problems who are living in Wales. By addressing the stigma …
Antiepiligrin cicatricial pemphigoid without mucous membrane involvement
Authors: J.J.A. Buijsrogge, H.H. Pas, M.F. Jonkman
Journal: British Journal of Dermatology (2005)

Journal Article Antiepiligrin cicatricial pemphigoid without mucous membrane involvement Get access J.J.A. Buijsrogge, J.J.A. Buijsrogge Centre for Blistering Diseases, Department of Dermatology, University Medical Centre Groningen, PO Box 30.001, 9700 RB Groningen, the Netherlands Search for other works by this author on: Oxford Academic Google Scholar H.H. Pas, H.H. Pas Centre for Blistering Diseases, Department of Dermatology, University Medical Centre Groningen, PO Box 30.001, 9700 RB Groningen, the Netherlands Search for other works by this author on: Oxford Academic Google Scholar M.F. Jonkman M.F. Jonkman Centre for Blistering Diseases, Department of Dermatology, University Medical Centre Groningen, PO Box 30.001, 9700 RB Groningen, the Netherlands M.F. Jonkman, E‐mail: m.f.jonkman@derm.umcg.nl Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 153, Issue 5, 1 November 2005, Pages 1080–1081, https://doi.org/10.1111/j.1365-2133.2005.06919.x Published: 01 November 2005
The Future Supply of Physicians
Authors: John K. Iglehart
Journal: New England Journal of Medicine (1986)

New and stronger pressures to reduce federal spending and growing concern within the medical profession that a surplus of physicians already exists or looms in some regions are focusing greater attention on the question of how many medical students the United States should be training. Certainly no consensus has emerged, but federal policies are increasingly based on the administration's assertion that a physician surplus already exists. Because the Reagan administration is determined to reduce federal responsibilities in the social sphere, however, the government has made little connection between the bountiful supply of practicing physicians and the opportunity to provide services . . .
Atrial fibrillation is associated with an increased risk for mortality and heart failure progression in patients with asymptomatic and symptomatic left ventricular systolic dysfunction: a retrospective analysis of the SOLVD trials
Authors: DanielL Dries, DerekV Exner, BernardJ Gersh, MichaelJ Domanski, MyronA Waclawiw, LynneW Stevenson
Journal: Journal of the American College of Cardiology (1998)

Objective. This study undertook to determine if the presence of atrial fibrillation in patients with asymptomatic and symptomatic left ventricular dysfunction was associated with increased mortality and, if so, whether the increase could be attributed to progressive heart failure or arrhythmic death. Background. Atrial fibrillation is a common condition in heart failure with the potential to impact hemodynamics and progression of left ventricular systolic dysfunction as well as the electrophysiologic substrate for arrhythmias. The available data do not conclusively define the effect of atrial fibrillation on prognosis in heart failure. Methods. A retrospective analysis of the Studies of Left Ventricular Dysfunction Prevention and Treatment Trials was conducted that compared patients with atrial fibrillation to those in sinus rhythm at baseline for the risk of all-cause mortality, progressive pump-failure death and arrhythmic death. Results. The patients with atrial fibrillation at baseline, compared to those in sinus rhythm, had greater all-cause mortality (34% vs. 23%, p < 0.001), death attributed to pump-failure (16.7% vs. 9.4%, p < 0.001) and were more likely to reach the composite end point of death or hospitalization for heart failure (45% vs. 33%, p < 0.001), but there was no significant difference between the groups in arrhythmic deaths. After multivariate analysis, atrial fibrillation remained significantly associated with all-cause mortality (relative risk [RR] 1.34, 95% confidence interval [CI] 1.12 to 1.62, p = 0.002), progressive pump-failure death (RR 1.42, 95% CI 1.09 to 1.85, p = 0.01), the composite end point of death or hospitalization for heart failure (RR 1.26, 95% CI 1.03 to 1.42, p = 0.02), but not arrhythmic death (RR 1.13; 95% CI 0.75 to 1.71; p = 0.55). Conclusions. The presence of atrial fibrillation in patients with asymptomatic and symptomatic left ventricular systolic dysfunction is associated with an increased risk for all-cause mortality, largely explained by an increased risk for pump-failure death. These data suggest that atrial fibrillation is associated with progression of left ventricular systolic dysfunction.
TESTIMONIALS FOR YEAST
Authors: Roland Grassberger
Journal: JAMA (1933)

<h3>To the Editor:</h3> —It has been brought to the attention of the Vienna Medical Faculty that medical testimonials favoring one of the yeast preparations placed on the market by the Fleischmann Yeast Company in New York have been placed at the disposal of this company by certain members of the medical faculty in Vienna, and that these testimonials are spread and misused for advertising purposes in American illustrated and other magazines in quack-fashion. Even though the testifiers in question cannot personally be responsible for this misuse, since they have no power of might against the unfair methods employed by the yeast firm, nevertheless the Vienna Medical Faculty instituted an extensive inquiry into this matter in June, 1932. The members at fault were officially sharply reproved by the dean, and all members of the faculty were forbidden to give any testimonials intended for advertising purposes in the future. All of the
Linking Insurance Coverage for Innovative Invasive Procedures With Participation in Clinical Research
Authors: Franklin G. Miller, Steven D. Pearson
Journal: JAMA (2011)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Association between tuberculosis recurrence and interferon-γ response during treatment
Authors: Nguyen Thi Le Hang, Ikumi Matsushita, Takuro Shimbo, Le Thi Hong, Do Bang Tam, Luu Thi Lien, Pham Huu Thuong, Vu Cao Cuong, Minako Hijikata, Nobuyuki Kobayashi, Shinsaku Sakurada, Kazue Higuchi, Nobuyuki Harada, Hiroyoshi Endo, Naoto Keicho
Journal: Journal of Infection (2014)
Alastair Thomas Orr Speirs
Authors: J. Varnham
Journal: BMJ (2015)

<b><i>Objective:</i></b> To investigate the involvement of the rhinal cortex and the hippocampus in the processing of famous faces in contrast to nonfamous faces using intracranial event-related potentials (ERPs), and to analyze repetition effects for famous and nonfamous faces. <b><i>Methods:</i></b> ERPs were elicited by pictures of famous and nonfamous faces and recorded from rhinal and hippocampal sites of intracranial electrodes in 10 presurgical patients with unilateral medial temporal lobe epilepsy. Famous and nonfamous faces were presented twice and mixed with distorted faces serving as targets. There was no instruction for an overt discrimination between famous and nonfamous faces. In contrast to nonfamous faces, famous faces stimulate processes related with access and retrieval of semantic memory. <b><i>Results:</i></b> All faces evoked anterior medial temporal lobe N400-like (AMTL-N400) potentials in the rhinal cortex and P600-like potentials in the hippocampus. The AMTL-N400 and the hippocampal P600 amplitudes were larger for famous faces than for nonfamous faces. Mean amplitudes of the first and second presentation of famous faces suggest a repetition effect for the rhinal sites; however, they are significant only in the later signal components. No repetition effect was found for nonfamous faces and for potentials from the hippocampus. <b><i>Conclusion:</i></b> The anterior medial temporal lobe N400 and the hippocampal P600 may be related to the access and retrieval of person-specific semantic memory.
Increased group II phospholipase A2 in colonic mucosa of patients with Crohn's disease and ulcerative colitis.
Authors: T Minami, H Tojo, Y Shinomura, Y Matsuzawa, M Okamoto
Journal: Gut (1994)

The immunochemical protein content of group II phospholipase A2 (PLA2) and PLA2 enzymatic activity were measured for colonic mucosal biopsy samples obtained from patients with either Crohn's disease of the colon or ulcerative colitis, and control patients without inflammatory bowel disease. Immunoreactive group II PLA2 (IR-PLA2 II) content and PLA2 activity in actively inflamed colonic mucosa of Crohn's disease patients were significantly higher than those in inactively inflamed mucosa of Crohn's disease patients and the colonic mucosa of controls. IR-PLA2 II content and PLA2 activity in severely inflamed mucosa of ulcerative colitis patients were significantly higher than those in the colonic mucosa of the controls. Mucosal PLA2 enzymatic activity was closely correlated with mucosal IR-PLA2 II content in patients with Crohn's disease and ulcerative colitis. These results suggest that an increase in PLA2 enzymatic activity in inflamed colonic mucosa of Crohn's disease and ulcerative colitis was mainly attributed to increased protein content of group II PLA2, and that an increase in mucosal group II PLA2 may be involved in the pathogenesis of intestinal inflammation of Crohn's disease and ulcerative colitis.
Reversal by verapamil of defect in sodium transport in leucocytes in essential hypertension.
Authors: H H Gray, L Poston, P J Hilton, S J Smith, N D Markandu, G A MacGregor
Journal: BMJ (1984)

The effect of treatment with verapamil on cell sodium transport was studied in the leucocytes of patients with essential hypertension. Previously described abnormalities of sodium efflux rate constant and intracellular sodium content were confirmed, the component of the sodium efflux rate constant sensitive to ouabain being lower and the intracellular sodium content higher in the patients compared with controls. Verapamil reversed these abnormalities and reduced blood pressure.
A MISLEADING NASOPHARYNGEAL FIBROMATOID
Authors: O. Jason Dixon
Journal: JAMA (1925)

<h3>History.</h3> —Mrs. S. A., aged 30, came to my clinic, Sept. 13, 1923, with the complaint of a lump in the back of her throat. She first noticed that she was unable to breathe through her nose following an attack of influenza in 1921. She was bothered with the change of her voice caused by the nasal obstruction, and consulted her family physician at that time, who told her that she had nasal polypi, which should be removed. She worried along with this condition until she became alarmed on account of difficulty in breathing while asleep or lying on her back. She had recently been bothered with night terrors, and had a feeling that she was choking to death. There had been no bleeding or discharge from the nose or throat, and, aside from a constant headache radiating down the back of each ear and pain in her eyes, she