tbuckley/cabot-search huggingface dataset:
Some Peculiar Biological and Biochemical Properties of a Mouse Hepatoma Induced by Chrysoidin. I. Biological and Biochemical Characteristics of the Hepatoma&lt;xref ref-type="fn" rid="FN1"&gt;2&lt;/xref&gt;
Authors: Zygmunt Albert, Marian Orłowski
Journal: JNCI Journal of the National Cancer Institute (1960)

A transplanted hepatoma of the mouse is described. The neoplasm arose in the liver of a C57BL mouse after prolonged feeding of chrysoidin (2,4′-azodianiline). It was transplantable into only strain C57BL mice and their F1 hybrids from crosses with strains RIII and A. Thirty-four passages have been performed with 80 to 100 percent takes. About 55 percent of the mice had metastases, almost exclusively to the lungs. Histologically, the neoplasm resembled those described by other authors except that intranuclear inclusions were more conspicuous and more frequent. In some instances Kupffer cells, the cytoplasm, and intranuclear inclusions of hepatoma cells contained brown protoporphyrin pigment.
Survey of Clinical Pediatrics.
Authors: Edward Wasserman, Lawrence B. Slobody
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Dynamic changes of the luminal and mucosa-associated gut microbiota during and after antibiotic therapy with paromomycin
Authors: Femke-Anouska Heinsen, Henrik Knecht, Sven C Neulinger, Ruth A Schmitz, Carolin Knecht, Tanja Kühbacher, Philip C Rosenstiel, Stefan Schreiber, Anette K Friedrichs, Stephan J Ott
Journal: Gut Microbes (2015)

Gut microbiota play a key role in the host's health system. Broad antibiotic therapy is known to disrupt the microbial balance affecting pathogenic as well as host-associated microbes. The aim of the present study was to investigate the influence of antibiotic paromomycin on the luminal and mucosa-associated microbiota at the DNA (abundance) and RNA (potential activity) level as well as to identify possible differences. The influence of antibiotic treatment on intestinal microbiota was investigated in 5 healthy individuals (age range: 20–22 years). All participants received the antibiotic paromomycin for 3 d. Fecal samples as well as sigmoidal biopsies were collected before and immediately after cessation of antibiotic treatment as well as after a recovery phase of 42 d. Compartment- and treatment status-specific indicator operational taxonomic units (OTUs) as well as abundance- and activity-specific patterns were identified by 16S rRNA and 16S rRNA gene amplicon libraries and high-throughput pyrosequencing. Microbial composition of lumen and mucosa were significantly different at the DNA compared to the RNA level. Antibiotic treatment resulted in changes of the microbiota, affecting the luminal and mucosal bacteria in a similar way. Several OTUs were identified as compartment- and/or treatment status-specific. Abundance and activity patterns of some indicator OTUs differed considerably. The study shows fundamental changes in composition of gut microbiota under antibiotic therapy at both the potential activity and the abundance level at different treatment status. It may help to understand the complex processes of gut microbiota changes involved in resilience mechanisms and on development of antibiotic-associated clinical diseases.
Abstract 16140: Systemic Inflammatory Response Syndrome is Associated With Mortality After Transcatheter or Surgical Aortic Valve Replacement With a Greater Impact on Diabetic Patients
Authors: Jacob S Goldstein, Hersh S Maniar, Eric Novak, Michael Nassif, Anjan Tibrewala, Anna M Wittenberg, Cassandra Lawler, Alan Zajarias, Ralph J Damiano, Marc R Moon, Jennifer S Lawton, John M Lasala, Brian R Lindman
Journal: Circulation (2014)

Background:  An inflammatory response after cardiac surgery is associated with worse clinical outcomes, but recent trials to attenuate it have been neutral. Patients with aortic stenosis (AS) and diabetes have increased mortality after surgical (SAVR) or transcatheter (TAVR) aortic valve replacement, but some data suggest diabetics do better with TAVR. We evaluated the association between systemic inflammatory response syndrome (SIRS) and mortality after TAVR and SAVR and whether diabetes influenced this relationship.   Methods:  Patients (n=747) with severe AS treated with TAVR (n=264) or SAVR (n=483) between 1/2008 and 12/2013 were included. SIRS was defined by 4 criteria 12 to 48 hours after AVR: 1) white blood cell (WBC) count  12; 2) heart rate (HR) >90; 3) temp  38°C; or 4) respiratory rate >20. We evaluated the relationship between SIRS criteria met and intermediate (6 mo) all-cause death (60 died by 6 mo). Inverse propensity weighting (IPW) was performed on 44 baseline and procedural variables to minimize confounding.   Results:  All 4 SIRS criteria were met in 6% of TAVR patients and 11% of SAVR patients (p=0.02); this was associated with increased mortality (IPW adjusted HR 2.77; 95% CI 2.04-3.76; p 2, p   Conclusions:  SIRS is associated with increased mortality after SAVR or TAVR. It occurs more commonly after SAVR and has a greater impact on mortality in diabetic patients. These findings may have implications for treatment decisions in patients with AS, may help explain differences in outcomes between different AVR approaches, and identify diabetic patients as a high risk sub-group to target in clinical trials with therapies to attenuate SIRS.
Abstract 13955: Establishing a Prehospital Protocol for Local Emergency Services Improves Symptom Onset-to-Balloon Time in Patients With ST-Segment Elevation Myocardial Infarction
Authors: Dawn A Brester, Matthew Schmidt, William T Witmer, Scott T Weslow, David Mathias, Katie Sahajpal
Journal: Circulation (2014)

Background: Delay in symptom recognition and calling 911 for patients with ST-segment elevation myocardial infarction (STEMI) continues to challenge many hospitals’ STEMI systems. Research has historically focused on door-to-balloon time and inpatient treatment, with little known on the impact of engaging emergency services (EMS) to provide a team approach to patient care, from community education to prehospital activation. Purpose: Evaluate the impact of a collaboration with local EMS agencies in our institution’s STEMI system designed to develop a prehospital protocol and joint community education efforts. Methods: Data collected from NCDR ACTION Registry-Mission Lifeline reports from 2011 to 2013 was analyzed to identify recent trends in prehospital STEMI quality metrics. After evaluation of 2011 data, a regional plan was developed and implemented in 2012 to address prehospital system barriers, including public education and revision of a prehospital protocol. Results: In 2011, a majority of patients used private transport when having a STEMI. Following protocol implementation, STEMI patients were able to identify symptoms earlier and appropriately call 911 earlier. As a result, a first medical contact (FMC)-to-balloon time of &lt; 90 minutes increased to 72% of patients, time from symptom onset to balloon decreased, and postprocedure complication rate improved (Table). Conclusions: Establishing a collaborative prehospital protocol between hospitals and EMS can have a positive impact on outcomes in STEMI patients. With more awareness and earlier notification of incoming STEMI patients, hospitals can significantly decrease symptom onset-to-balloon time. Evaluation of time from symptom onset to device activation may be a better way to measure quality than door-to-balloon time, as evidenced by a decrease in postprocedure complications associated with decreased overall times.
Roentgen Examinations in Acute Abdominal Diseases
Authors: Johan Cappelen Frimann-Dahl
Journal: JAMA (1952)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Abstract 2916: Childhood BMI is associated with risk of adult pancreatic cancer
Authors: Leticia M. Nogueira, Rachael Stolzenberg-Solomon, Michael Gamborg, Thorkild Sørensen, Jennifer Baker
Journal: Cancer Research (2014)

Abstract The incidence and death rate for pancreatic cancer, the fourth leading cause of cancer death in the U.S., have been increasing. Excess weight through adulthood is one of the few modifiable risk factors for pancreatic cancer. Childhood obesity rates have increased more rapidly that adulthood obesity in the U.S, but its effects on pancreatic cancer risk are not clear. Hence, the objective of this study is to test the hypothesis that childhood weight is associated with pancreatic cancer risk later in life. We evaluated the association of body mass index (BMI) measured at ages 7-13 with risk of pancreatic cancer later in life in 288,423 children from the Copenhagen School Health Records Register who were born between 1930-1981. These data were linked with the Danish Cancer Registry to identify incident pancreatic cancer cases from 1977-2011. Follow-up ended on the date of pancreatic cancer diagnosis, death, emigration, 70th birthday, or December 31st 2010, whichever came first. Hazard Ratios (HR) and 95% confidence intervals (CI) were calculated for age specific BMI z-scores using Cox proportional hazards stratified on birth cohort and gender. Restricted cubic splines analysis was used to test for linearity. There were 1163 pancreatic cancer cases during the 6,918,420 person-years of follow up. Childhood BMI was associated with pancreatic cancer risk in males and females. At age 10, for example, HR per one unit increase in BMI z-scores was 1.17 (CI: 1.08, 1.26). The observed association did not deviate from linearity. Our results support the hypothesis that higher childhood body weight is associated with increased pancreatic cancer risk later in life. Citation Format: Leticia M. Nogueira, Rachael Stolzenberg-Solomon, Michael Gamborg, Thorkild Sørensen, Jennifer Baker. Childhood BMI is associated with risk of adult pancreatic cancer. [abstract]. In: Proceedings of the 105th Annual Meeting of the American Association for Cancer Research; 2014 Apr 5-9; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2014;74(19 Suppl):Abstract nr 2916. doi:10.1158/1538-7445.AM2014-2916
ABDOMINAL PAIN IN PULMONARY THROMBOSIS
Authors: William S. Middleton
Journal: Annals of Internal Medicine (1943)

Article1 March 1943ABDOMINAL PAIN IN PULMONARY THROMBOSISWILLIAM S. MIDDLETON, F.A.C.P.WILLIAM S. MIDDLETON, F.A.C.P.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-18-3-345 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptIn the past 16 years the antemortem diagnosis of pulmonary thrombosis has been made in 53 subjects disclosing this lesion at necropsy in the Wisconsin General Hospital. The criteria for this clinical diagnosis are familiar but frequently minimized. An analysis of these data is, therefore, undertaken before recounting the unusual occurrence of abdominal pain in pulmonary thrombosis.The incidence of pulmonary thrombosis was much more frequent in men than in women (41 men to 12 women, a ratio of 3.4: 1). The age distribution follows:Although the dispersion is quite wide, one-half of the incidence appeared in patients between 41...References1. RICHRESNIK ARWH: On the mechanism of jaundice following pulmonary infarction in patients with heart failure, Bull. Johns Hopkins Hosp., 1926, xlvii, 75. Google Scholar2. KEEFERRESNIK CSWH: Jaundice succeeding pulmonary infarction in myocardial failure, Jr. Clin. Invest., 1926, ii, 375 and 389. CrossrefGoogle Scholar3. FÖRSTER E: Ein Fall von obturierendem Thrombus im rechten Ast der Pulmonalis und isolierter Trikuspidalinsuffizienz, Wien. med. Wchnschr., 1922, lxxii, 616. Google Scholar4. POUCHARR JFR: Thrombosis of pulmonary artery, Am. Rev. Tuberc., 1938, xxxvii, 394. Google Scholar5. DE TAKATSBECKFENN GWCGK: Pulmonary embolism, Surgery, 1939, vi, 339. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Madison, Wisconsin*Received for publication March 26, 1942. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byMassive thrombosis as a result of triple infestation of the pulmonry arterial circulation by ascaris, candida, and mucorFlow murmur associated with partial occlusion of the right pulmonary arteryEmbolectomy for Chronic Pulmonary Embolism and HypertensionThrombotic occlusion of the large pulmonary arteries.Chronic thrombotic obstruction of major pulmonary arteriesMassive Thrombotic Occlusion of the Large Pulmonary ArteriesCHRONIC MASSIVE PULMONARY ARTERY THROMBOSIS*ALFRED RING, M.D., JENS R. BAKKE, M.D.THROMBOSIS OF THE MAIN PULMONARY ARTERIESPropagating Pulmonary Artery Thrombosis 1 March 1943Volume 18, Issue 3Page: 345-349KeywordsAbdominal painAge distributionLesionsThrombosis ePublished: 1 December 2008 Issue Published: 1 March 1943 PDF downloadLoading ...
GLOBAL STRATEGY IN PREVENTIVE MEDICINE
Authors: K F MEYER
Journal: Annals of Internal Medicine (1950)

Article1 August 1950GLOBAL STRATEGY IN PREVENTIVE MEDICINEK. F. MEYER, M.D.K. F. MEYER, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-33-2-275 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe great honor in the invitation of the Board of Regents of the American College of Physicians to serve as the James D. Bruce Memorial Lecturer in Preventive Medicine is traditionally interpreted as an opportunity to present to this convocation an appraisal of newer practices in a field of medicine which had its origin in the ancient world. Long before the days of Hippocrates, man sought to stem the tides of the diseases that threatened him, but over all these early efforts in the practice of preventive medicine broods the darkness of man's ignorance and helplessness. The Grecian sculptor, Sosius,...Bibliography1. Ryle JA: Social medicine: its meaning and its scope, Brit. M. J. 2: 633-636, 1943. CrossrefMedlineGoogle Scholar2. Newman G: An outline of the practice of preventive medicine, 1926, His Majesty's Stationery Office, London. Google Scholar3. Sigerist HE: The people's misery: mother of disease, address delivered in 1790 by Johann Peter Frank. Introduction. Bull. Hist. Med. 9: 81-87, 1941. Google Scholar4. Shrewsbury JF: The plague of Athens, Bull. Hist. Med. 24: 1-25, 1950. Google Scholar5. Burnet FM: Virus as organism. Evolutionary and ecological aspects of some human virus diseases, 1945, Harvard University Press, Cambridge, Mass. Google Scholar6. Van Beneden PJ: Animal parasites and messmates, 1876, D. Appleton & Co., New York. Google Scholar7. Andrewes CH: Adventures among viruses. II. Epidemic influenza, New England J. Med. 242: 197-203, 1950. CrossrefMedlineGoogle Scholar8. Soper FL: Personal communication, 1948. Google Scholar9. Sharif M: Quoted in: Active measures against plague, Chron. World Health Organ. 3: 269-274, 1949. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: San Francisco, California*Presented at the Thirty-First Annual Session of the American College of Physicians, Boston, Mass., April 17, 1950. Nextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byWanted: The Practice of Preventive Medicine 1 August 1950Volume 33, Issue 2Page: 275-291KeywordsPreventive medicine Issue Published: 1 August 1950 Copyright & PermissionsCopyright, 1950, by The American College of PhysiciansPDF downloadLoading ...
Preeclampsia, Placental Insufficiency, Autism, and Antiphospholipid Antibodies—Reply
Authors: Cheryl K. Walker, Paul Ashwood, Irva Hertz-Picciotto
Journal: JAMA Pediatrics (2015)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Pediatrics HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Pediatrics journal
Professionalism, Governance, and Self-regulation of Medicine
Authors: Howard Bauchner, Phil B. Fontanarosa, Amy E. Thompson
Journal: JAMA (2015)

A revolution in medicine is occurring and is directly related to several major factors, including substantial changes in the health care system, largely due to the Affordable Care Act; remarkable scientific advances and an accelerated pace of discovery in biomedical science 1 ; increasing recognition of the need to practice restraint with respect to both diagnostic testing and therapeutic interventions; the promise of personalized medicine; more physicians being employed by large medical organizations; the increasing trend of consolidation and corporatization of health care delivery; and heightened public demands and expectations for transparency and accountability in health care. 2 At the same time, fundamental aspects affecting physician education and certification have come under intense scrutiny, with expansion of the number of medical schools, critical examination of government funding for residency training, and recent contentious debates regarding maintenance of board certification. 3onsidering these fundamental, dynamic, and rapid changes, there also could be challenges to and changes in the well-established governance structure and self-regulating functions involving the medical profession.Accordingly, this is an appropriate time to reexamine the various governing and professional bodies that influence the education, licensing, certification and recertification, and employment of physicians and, perhaps more importantly, to highlight the critically important and distinctive characteristic of medicineprofessionalism.How a profession self-governs has long been debated by scholars.What is its responsibility to its members and the public?Should medicine be held to a different standard than other professions?With the increasing proportion of physicians employed by health care systems, what is the role of employers in governing and overseeing professionalism among physician-employees?If medicine does not selfgovern effectively and responsibly, who should provide oversight?The banking and accounting industries are now subject to more federal oversight, at least in part because of their failure to effectively self-regulate.This issue of JAMA includes a series of Viewpoints by scholars and academic leaders about the responsibility and accountability of medicine to self-govern, self-regulate, and ensure the highest degree of professionalism.To reflect additional perspectives, 2 Viewpoints are written by authors from the United Kingdom and from Canada, and 3 Viewpoints are written by authors from disciplines other than medicine.Among the major issues addressed are the key roles and responsibilities of modern governing and accrediting bodies and of professional organizations and societies in ensuring effective governance and professionalism in medicine, as well as what these entities are doing and should do differently to enhance self-governance, safeguard self-regulation, and foster professionalism among physicians.