tbuckley/cabot-search huggingface dataset:
Fortnightly Review: Familial breast cancer
Authors: D G R Evans, I S Fentiman, K McPherson, D Asbury, B A J Ponder, A Howell
Journal: BMJ (1994)

<h3>Abstract</h3> <h3>Background</h3> Stroke remains a leading cause of disability and death worldwide. It has become apparent that inflammation and immune mediators have a pre-dominant role in initial tissue damage and long-term recovery following the injury. Still, different immunosuppressed mouse models are necessary in stroke research e.g., to evaluate therapies using human cell grafts. Despite mounting evidence delineating the importance of inflammation in the stroke pathology, it is poorly described to what extent partial immune deficiency influences the overall stroke outcome. <h3>Methods</h3> Here, we assessed the stroke pathology of popular genetic immunodeficient mouse models, i.e., NOD scid gamma (NSG) and recombination activating gene 2 (Rag2<sup>-/-</sup>) mice as well as pharmacologically immunosuppressed mice and compared them to immune competent, wildtype (WT) C57BL/6J mice up to three weeks after injury. We performed histology, gene expression profiling, serum analysis and functional behavioural tests to identify the impact of immunosuppression on the stroke progression. <h3>Results</h3> We detected distinct changes in microglia infiltration, scar-forming and vascular repair in immune-suppressed mice three weeks after injury. Gene expression analysis of stroked tissue revealed the strongest deviation from immune competent mice was observed in NSG mice, for instance, affecting immunological and angiogenic pathways. Pharmacological immunosuppression resulted in the least variation in gene expression compared with the WT. Major differences have been further identified in the systemic inflammatory response following stroke acutely and three weeks following injury. These anatomical, genetic, and systemic changes did not affect functional deficits and recovery in a time course of three weeks. To determine whether the timing of immunosuppression after stroke is critical, we compared mice with acute and delayed pharmacological immunosuppression after stroke. Mice with a delayed immunosuppression (7d) after stroke showed increased inflammatory and scarring responses compared to animals acutely treated with tacrolimus, thus more closely resembling WT pathology. Transplantation of human cells in the brains of immunosuppressed mouse models led to prolonged cell survival in all immunosuppressed mouse models, which was most consistent in NSG and Rag2<sup>-/-</sup> mice. <h3>Conclusions</h3> In sum, we detected distinct anatomical and molecular changes in the stroke pathology between the individual immunosuppressed mouse models that should be carefully considered when selecting an appropriate mouse model for stroke research.
Kutan skuamöz hücreli karsinoma in situ(Bowen hastalığı) için imiquimod %5 kremi monoterapisi: Randomize, çift kör, plasebo kontrollü deney
Authors: Girish K. Patel, Richard Goodwin, Maureen Chawla, Peter Laidler, Patricia E. Price, Andrew Y. Finlay veRichard J. Motley
Journal: Journal of the American Academy of Dermatology (2006)
Evaluation of microsatellite analysis in urine sediment for diagnosis of bladder cancer.
Authors: Anne Schneider, Stéphane Borgnat, Hervé Lang, Odile Régine, Véronique Lindner, Maysoun Kassem, Christian Saussine, Pierre Oudet, Didier Jacqmin, Marie Pierre Gaub
Journal: Cancer Research (2000)

Alterations at microsatellite DNA markers in cells exfoliated in urine have been correlated to the presence of bladder cancer. To check the feasibility of such noninvasive analysis to routinely diagnose bladder cancers, we have developed a highly sensitive method using fluorescent PCR to search for DNA microsatellite alterations in urine sediment compared with a blood paired sample. One hundred eighty-three patients were included in our study. This population comprised 103 bladder cancers (64 pTa stages), the complement representing controls and other benign or malignant diseases. Results of the analysis at 17 loci in a blinded study were compared with cystoscopy and/or pathology. The high reproducibility of this technique and the analysis of 26 control patients allowed us to determine for each microsatellite a cutoff characterizing a significant allelic imbalance. For bladder cancer detection, the overall sensitivity of the test was 84%. Using this procedure, we identified alterations in 81%, 84%, 91%, and 100% of pTa, pT1, pT2, and >pT2 stages, respectively. This corresponds to 79%, 82%, and 96% sensitivity for grades I, II, and III, respectively. Interestingly, for routine purposes, we observed an overall sensitivity of 80% (76% for pTa stages) when only the eight most rearranged microsatellites were considered. In conclusion, the noninvasive feature combined with the rapidity of this fluorescent and highly sensitive technique for the detection of early stages provides us with a useful help for the diagnosis of bladder cancer.
Effect of Previously Injected Immune Serum and Tissue on the Survival of Tumor Grafts in Mice&lt;xref ref-type="fn" rid="fn1"&gt;&lt;sup&gt;2&lt;/sup&gt;&lt;/xref&gt;
Authors: Nathan Kaliss, Norman Molomut, Jean L. Harriss, Sidney D. Gault
Journal: JNCI Journal of the National Cancer Institute (1953)

Effect of Previously Injected Immune Serum and Tissue on the Survival of Tumor Grafts in Mice Get access Nathan Kaliss, Nathan Kaliss Search for other works by this author on: Oxford Academic PubMed Google Scholar Norman Molomut, Norman Molomut Search for other works by this author on: Oxford Academic PubMed Google Scholar Jean L. Harriss, Jean L. Harriss Search for other works by this author on: Oxford Academic PubMed Google Scholar Sidney D. Gault Sidney D. Gault Roscoe B. Jackson Memorial Laboratory, Bar Harbor, Maine, and the Waldemar Medical Research Foundation, Brooklyn, N. Y. Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 13, Issue 4, February 1953, Pages 847–850, https://doi.org/10.1093/jnci/13.4.847 Published: 01 February 1953 Article history Received: 17 September 1952 Published: 01 February 1953
Determination of ancestral alleles for human single-nucleotide polymorphisms using high-density oligonucleotide arrays
Authors: Joseph G. Hacia, Jian-Bing Fan, Oliver Ryder, Li Jin, Keith Edgemon, Ghassan Ghandour, R. Aeryn Mayer, Bryan Sun, Linda Hsie, Christiane M. Robbins, Lawrence C. Brody, David Wang, Eric S. Lander, Robert Lipshutz, Stephen P.A. Fodor, Francis S. Collins
Journal: Nature Genetics (1999)
A Novel Feature-Tracking Echocardiographic Method for the Quantitation of Regional Myocardial Function
Authors: Bahar Pirat, Dirar S. Khoury, Craig J. Hartley, Les Tiller, Liyun Rao, Daryl G. Schulz, Sherif F. Nagueh, William A. Zoghbi
Journal: Journal of the American College of Cardiology (2008)
AIDS activists import cheap drugs into South Africa
Authors: Pat Sidley
Journal: BMJ (2000)

An HIV/AIDS activist group, the Treatment Action Campaign, has illegally imported into South Africa quantities of the generic equivalent of Diflucan (fluconazole), the drug manufactured by Pfizer that is used to treat opportunistic AIDS infections. Organisers have been charged by police with importing an unregistered drug.

The drug is particularly expensive in South Africa's private sector, and, although substantially less expensive in the public sector, it is nevertheless out of reach of the hundreds of thousands who need it. The drug is used to treat cryptococcal meningitis and oesophageal candiditis.

Pfizer has offered the South African government supplies of …
Abstract 12091: Aldosterone Enhances Cardiac Rupture after Myocardial Infarction through Calcium/Calmodulin-Dependent Protein Kinase II
Authors: B. Julie He, Mei-ling Joiner, Madhu Singh, Paari Dominic Swaminathan, Elizabeth Luczak, Olha Koval, William Kutschke, Chantal Allamargot, Jinying Yang, Xiaoqun Guan, Kathy Zimmerman, Isabella Grumbach, Robert Weiss, Douglas Spitz, Curt Sigmund, Matthijs Blankesteijn, Stephane Heymans, Peter Mohler, Mark Anderson
Journal: Circulation (2011)

B. Julie He, 2011 Finalist and Presenting Author
Asthma and myeloperoxidase gene promoter region polymorphism
Authors: Margarida Cortez e Castro, Andreia Matos, Joana Ferreira, Ridhi Prabhudas, Manuel Bicho
Journal: European Respiratory Journal (2014)

Aim of the study: SNP in MPO, −463GgA (rs2333227) with asthma severity and its relation with MPO plasma levels. Methods:Asthmatics (n= 45) compared with a control group (n=34); polymorphisms analyzed by PCR-RFLP. MPO plasma levels by ELISA kit- RD 0.05. Results:MPO gene polymorphisms and levels in 45 patients and 34 controls, all males. In asthmatics frequencies of allele A were 52.2% and allele G: 47.8%. In controls, frequencies of allele A were 28% and allele G : 72% . There is statistical differences (p=0.000); allele A is more frequent in asthmatics and Allele G in controls .Genotypes in asthmatics were: GG: 20%; AG:55.6 %; AA: 24.4% and for controls: GG: 53%; AG: 38%; AA: 9%. There is statistical differences (p=0.007). The mean MPO levels were more elevated in asthmatics (19,3±23,11ng/mL) when compared with control group (13±33,37ng/mL) (p=0.004).There are differences in MPO levels by genotypes (p=0.009) in the asthmatics: GG:40,3±37,02 ng/mL; AG:16,5±13,73 ng/mL; AA:18,6±12,95 ng/mL. There are no differences in MPO levels by genotypes (p=0.176) in the control-group. There are differences in MPO concentration by genotypes GGvsGA+AA in the asthmatics(p=0.002). There are no differences in MPO levels by genotypes in controls GGvsGA+AA (p=0.062). In asthmatics there are a trend to have differences between allergics and non-allergics (p=0.05) being the levels in allergics (19,00±22,18 ng/mL)lower than non-allergic (55,20±33,66 ng/mL). Conclusion: This SNP in MPO and its relation with MPO plasma levels could lead to different endotypes/phenotypes among asthmatic patients.
Redefining Diastolic Dysfunction Grading
Authors: Hiroshi Kuwaki, Masaaki Takeuchi, Victor Chien-Chia Wu, Kyoko Otani, Yasufumi Nagata, Atsushi Hayashi, Mai Iwataki, Shota Fukuda, Hidetoshi Yoshitani, Haruhiko Abe, Yutaka Otsuji
Journal: JACC. Cardiovascular imaging (2014)
Does allergic rhinitis exist in infancy? Findings from the PARIS birth cohort
Authors: M. Herr, B. Clarisse, L. Nikasinovic, C. Foucault, A.-M. Le Marec, J.-P. Giordanella, J. Just, I. Momas
Journal: Allergy (2010)

To cite this article: Herr M, Clarisse B, Nikasinovic L, Foucault C, Le Marec A-M, Giordanella J-P, Just J, Momas I. Does allergic rhinitis exist in infancy? Findings from the PARIS birth cohort. Allergy 2011; 66: 214–221. Background: Early onset of allergic rhinitis (AR) is poorly described, and rhinitis symptoms are often attributed to infections. This study analyses the relations between AR-like symptoms and atopy in infancy in the PARIS (Pollution and Asthma Risk: an Infant Study) birth cohort. Methods: Data on AR-like symptoms (runny nose, blocked nose, sneezing apart from a cold) were collected using a standardized questionnaire administered during the health examination at age 18 months included in the follow-up of the PARIS birth cohort. Parental history of allergy and children's atopy blood markers (blood eosinophilia ≥470 eosinophils/mm3, total immunoglobulin E ≥45 U/ml and presence of allergen-specific IgE) were assessed. Associations were studied using multivariate logistic regression models adjusted for potential confounders. Results: Prevalence of AR-like symptoms in the past year was 9.1% of the 1850 toddlers of the study cohort. AR-like symptoms and dry cough apart from a cold were frequent comorbid conditions. Parental history of AR in both parents increased the risk of suffering from AR-like symptoms with an OR 2.09 (P = 0.036). Significant associations were found with the presence of concurrent biological markers of atopy, especially blood eosinophilia and sensitization to house dust mite (OR 1.54, P = 0.046 and OR 2.91, P = 0.042) whereas there was no relation with sensitization to food. Conclusions: These results support the hypothesis that AR could begin as early as 18 months of life. Suspicion of AR should be reinforced in infants with parental history of AR or biological evidence of atopy, particularly blood eosinophilia and sensitization to inhalant allergens.
Abstract 4557: Mode of Death After Contemporary Percutaneous Coronary Intervention: A Report From the EVENT Multicenter Registry
Authors: Joshua M Stolker, David J Cohen, Jason B Lindsey, Kevin F Kennedy, Neal S Kleiman, Steven P Marso
Journal: Circulation (2009)

BACKGROUND When selecting clinical trial endpoints, some investigators prefer to use cardiovascular death (CVD) while others believe that all-cause mortality is more relevant. The frequencies of CV...
Mutations in the X-linked and autosomal recessive forms of chronic granulomatous disease
Authors: D Roos, M de Boer, F Kuribayashi, C Meischl, RS Weening, AW Segal, A Ahlin, K Nemet, JP Hossle, E Bernatowska-Matuszkiewicz, H Middleton-Price
Journal: Blood (1996)
The transition from discovery by genome-wide association studies to validation of clinical risk models: Where are we, what will it take, and when can we expect to be there?
Authors: Stephen J. Chanock
Journal: Clinical Cancer Research (2010)

Abstract Genome-wide association studies (GWAS) have emerged as an important tool for discovering regions of the genome that harbor genetic variants that confer risk for different types of cancers. The success of GWAS has been a consequence of the convergence of new technologies that can genotype hundreds of thousands of common single nucleotide polymorphism (SNP) markers together with comprehensive annotation of genetic variation. This approach has provided the opportunity to scan across the genome in a sufficiently set of cases and controls without a set of prior hypotheses in search of susceptibility alleles with low effect sizes. So far, susceptibility alleles discovered thus far are common, namely, with a frequency in one or more population of greater than 5% and each allele confers a small contribution to the overall risk for the disease. In prostate cancer, there could be more than 35 distinct regions harboring common susceptibility alleles identified by GWAS whereas in lung cancer, a disease strongly driven by exposure to tobacco products, so far, only three regions have been conclusively established. To date, over 125 regions have been conclusively associated in over a dozen different cancers, yet no more than six regions have been associated with more than one distinct cancer type. GWAS are an important discovery tool that require extensive follow-up to map each region, investigate the biological mechanism underpinning the association and eventually test the optimal markers for assessing risk for a disease or its outcome, such as in pharmacogenomics. The early fruits of success employed by GWAS have opened new horizons for applying genetic variation to the early diagnosis, treatment and perhaps prevention of different types of cancers. At the same time, it has become apparent that the complex genomic architecture of disease susceptibility will require further discovery of uncommon and rare variants using next generation sequence technologies that contribute to different cancers before we can expect to establish robust tests of germline DNA to be clinically useful. To reach this goal, new studies will need to be designed to validate the utility of known genetic variants in assessing risk for cancer.
Abstract 552: Posterior Involvement Attenuates Predictive Value of ST-Segment Elevation in Lead V4R for Right Ventricular Involvement in Inferior Acute Myocardial Infarction
Authors: Masami Kosuge, Kazuo Kimura, Toshiaki Ebina, Kiyoshi Hibi, Kengo Tsukahara, Jyun Okuda, Noriaki Iwahashi, Toshiyuki Ishikawa, Kazuaki Uchino, Satoshi Umemura
Journal: Circulation (2008)

ST-segment elevation (ST ↑) ≥1.0 mm in lead V4R is considered a reliable marker of right ventricular involvement (RVI) in inferior acute myocardial infarction (IMI). However, the impact of posterior involvement (PI) on the relation between RVI and ST ↑ in lead V4R is unknown. We studied 267 patients with a first IMI who had total occlusion and TIMI 3 flow of the right coronary artery within 6 h after the onset. A 12-lead ECG, lead V4R, and leads V7–9 were recorded on admission. RVI was defined as occlusion proximal to the first right ventricular branch. The perfusion territory was assessed by angiographic distribution score, and PI was defined as a score of ≥0.7. Myocardial blush grade was assessed immediately after reperfusion. Patients were stratified according to the presense or absense of PI and RVI. Times to admission and reperfusion were similar in the 4 groups. RVI was associated with higher peak creatine kinase and higher rates of impaired myocardial reperfusion (blush grade 0/1) and congestive heart failure during hospitalization in the presense or absense of PI, especially the former. RVI was associated with a higher rate of ST ↑ in lead V4R in the absence, but not in the presence, of PI. ST ↑ in lead V4R identified RVI with sensitivities of 34% and 96% (p&lt;0.001) and specificities of 83% and 82% (NS) in the presence and absence of PI, respectively. In patients with reperfused IMI, RVI is associated with a larger infarct size and impaired myocardial reperfusion. However, the incidence of RVI diagnosed by ST ↑ in lead V4R was underestimated in the presence of posterior involvement. ST ↑ in lead V4R caused by RVI might be attenuated due to a reciprocal change in posterior ST ↑.
World's poorest depend on private health care
Authors: Tessa Richards
Journal: BMJ (2001)

Many of the world's poorest people are dependent on private healthcare providers, and paying for treatment can put them in debt and further poverty. In recognition of this, and of the need to adopt better strategies for ensuring that private healthcare providers contribute rather than erode public health objectives, a new guide has been published. It was produced jointly by the London School of Hygiene and Tropical Medicine and Options, an …
Carbonic anhydrase IX in the prediction of right ventricular dysfunction in patients with hemodynamically stable acute pulmonary embolism
Authors: Yasin Abul, Savas Ozsu, Ahmet Mentese, Ismet Durmus, Hayriye Bektas, Mehtap Pehlivanlar, Oguzhan Ekrem Turan, Aysegul Sumer, Asim Orem, Tevfik Ozlu
Journal: European Respiratory Journal (2013)

Background: Right ventricular dysfunction(RVD) defined by echocardiography and/or by natriuretic peptides is a well known predictor of prognosis in pulmonary embolism(PE) patients. Aims and objectives: This study investigated carbonic anhydrase IX levels for predicting echocardiographic RVD in PE patients.

Methods: Carbonic anhydrase IX and other cardiac biomarkers were compared between the pulmonary embolism patients with and without RVD on echocardiography. Results: A total of 150 normotensive PE patients were included.The levels of carbonic anhydrase IX,NT-proBNP and high sensitive cardiac troponin T were significantly elevated in PE patients with RVD on echocardiography(p  32.45 pg/mL was significant independent predictors of right ventricular dysfunction after the adjustment for the baseline characteristics at multivariate logistic regression (p=0.027). Conclusion: In conclusion, carbonic anhydrase IX is a significant serologic predictor of RVD in acute PE and correlates with systolic pulmonary arterial pressure.
A Manual of Practical Anatomy. A Guide to Dissection of the Human Body.
Authors: Thomas . Walmsley
Journal: JAMA (1922)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Brief Communication: C-Type Virus Particles in a Cell Line From a Lymphosarcoma of a Nude Mouse
Authors: Tommie Sue Tralka, Alan S. Rabson, Carl T. Hansen
Journal: JNCI Journal of the National Cancer Institute (1975)

C-type virus particles were observed by electron microscopy in cultures of a cell line (NML-1) derived from a lymphosarcoma that arose spontaneously in a nude NIH outbred mouse. The presence of such particles indicated that human tumors heterotransplanted in nude mice might become contaminated with murine oncornaviruses.
Abstract P380: The Cardiovascular Fate in Patients with Amputation or Revascularization for Critical Limb Ischemia
Authors: Paola De Rango, Massimo Lenti, Enrico Cieri, Alessandro Marucchini, Luca Farchioni, Alessandra Manzone
Journal: Circulation (2014)

Background: Critical limb ischemia (CLI) continues to be a significantly morbid disease for the aging population with high likelihood of cardiovascular mortality and morbidity. Objective: To analyze incidence and timing of all cause and cardiovascular mortality (CM) in patients who survived after intervention for CLI. Methods: Patients consecutively discharged with diagnosis of CLI during the period 2006-2008 were re-evaluated for cardiovascular morbidity after 2 years. Patients receiving revascularization either open or endovascular and those with primary major amputation were compared with Kaplan-Meier analyses. The effect of treatment on outcome was analyzed with Cox analysis. Results: There were 257 patients (171 men, aged 74.12y), 39 treated by primary major amputation and 218 by revascularization. During a mean follow-up of 37months, 81 patients died for all cause mortality and 35 for CM. Mean survival time was 57.4months. More than half deaths (n=44) occurred by 15 months with 21 patients dying in the first 6 months and 33 within the first 12 months. Thirty-five myocardial infarctions and 15 strokes occurred. Cumulative survival rate at 60 months was 54% for all cause mortality and 79% for CM. There was significantly worse survival in patients with primary amputation when compared to those receiving revascularization: rates for all cause mortality were 45% vs. 75% (p=0.001) and rates for CM were 68% vs. 90% (p&lt;0.0001), in primary amputation and revascularization group respectively at 42 months. Unadjusted odd ratios for all cause and cardiovascular mortality in patients with primary amputation vs. revascularization were 3.07 (95%CI 1.5-6.1, p=0.002) and 5.25 (95%CI 2.3-11.6, p&lt;0.0001), respectively. After adjusting for age and gender, primary amputation persisted as independent predictor of all cause (HR 2.76, p&lt;0.0001) and cardiovascular mortality (HR 5.11; p&lt;0.0001). Conclusion: Mortality and CM after 2 years in patients surviving from CLI procedures are high. Primary amputation is a strong predictor of poor prognosis in the mid-long term for patients with CLI. Most deaths occur in the first 15 months after treatment. This data may question the benefits of revascularization.