tbuckley/cabot-search huggingface dataset:
The staphylococcal scalded skin syndrome.
Authors: ROBERT L. DIMOND, HELMUT H. WOLFF, OTTO BRAUN-FALCO
Journal: British Journal of Dermatology (1977)

Histochemical and electron microscopic studies were carried out on the newborn mouse model of the staphylococcal scalded skin syndrome to investigate the mechanism of action of the staphylococcal epidermolytic toxin that causes it. Histochemical studies showed that an intra‐epidermal split develops below the subcorneal zone which is rich in catabolic enzymes (the so‐called esterase‐acid phosphatase‐rich band). However, histochemical alterations in the enzyme pattern could not be demonstrated. The earliest change revealed by electron microscopy was a widening of the intercellular space, with the formation of microvilli at the level between the stratum spinosum and stratum granulosum where the split later occurs. A clearing of the peripheral cytoplasm along the cell membranes was also revealed. In pre‐split areas, adhesion between cell membranes of adjacent cells seems to be lost; desmosomes continue to hold the cells together but the split develops when these are broken by mechanical pressure. Later, damaged cell membranes may be seen. Extracellular keratinosomes remain unchanged. Although these findings do not agree with the already divergent results of other studies, they help support the findings of all groups that cases of the Lyell syndrome produced by staphylococci do not occur through necrolysis; it is therefore inappropriate to continue applying the term ‘toxic epidermal necrolysis’ to such cases.
Comment on “Fluorotechnology Is Critical to Modern Life: The FluoroCouncil Counterpoint to the Madrid Statement”
Authors: Ian T. Cousins, Simona A. Balan, Martin Scheringer, Roland Weber, Zhanyun Wang, Arlene Blum, Miriam Diamond, Tony Fletcher, Gretta Goldenman, Christopher Higgins, Avery E. Lindeman, Graham Peaslee, Xenia Trier, Pim de Voogt
Journal: Environmental Health Perspectives (2015)
Patients prefer clinics to have non-descriptive titles
Authors: C Sonnex, C A Carne, S. Edwards
Journal: BMJ (1995)

EDITOR,—Yvonne Stedman and Max Elstein suggest that genitourinary medicine and family planning services should work closely together in an attempt to provide a comprehensive sexual health service for patients.1 Many genitourinary medicine clinics have for some time appreciated the need for sexual health care and provide skill in colposcopy, psychosexual medicine, and genital dermatology in addition to …
Abstract 4193: A Randomized, Double-blind, Double-dummy, Comparison of Efficacy and Tolerability of Fluvastatin XL alone, Ezetimibe alone and the Combination, in Patients with a History of Muscle Related Side Effects with other Statins
Authors: Evan A Stein, Christie M Ballantyne, Claudio Gimplewicz, Claudia Seper, Sajda Ghani
Journal: Circulation (2006)

Reduction of LDLC is the core of cardiovascular disease (CVD) prevention. Trials showing the lower the LDLC the lower the CVD risk have led to revision of the NCEP guidelines for high risk patients. Statins, the most effective class for achieving LDLC reduction, are generally well tolerated and serious side effects are rare. However in clinical practice muscle related side effects (MRSE), such as pain, cramps and weakness are more common than reported in clinical trials. A recent observational study of nearly 8,000 patients in primary care practice reported 10.5% MRSE with statins. MRSE were the major reason for discontinuation. Inability to use statins leaves physicians and patients minimal ability to achieve LDLC goals at any risk level. Fluvastatin XL (FXL) has a number of unique pharmacological features that suggest it would have a lower propensity for MRSE. The present trial, is the first randomized, double dummy, controlled trial done in patients with statin associated MRSE, to test the hypothesis that in such patients FXL 80 mg would be as well tolerated as a non-statin lipid lowering agent. Ezetimibe (EZE) 10 mg, a cholesterol absorption inhibitor, was selected as a widely used, effective well tolerated agent. The study randomized 199 mostly high-risk subjects with a history of statin related MRSE in 27 centers. After 4 week diet only lead-in patients were randomized to 12 week treatment with FXL + placebo (Pbo) EZE; EZE + Pbo FLX or FLX + EZE. Results are shown below: The present study demonstrates that patients with statins related MRSE tolerate FXL, either alone or as combination therapy with EZE, with MSRE side effects no different from that of EZE alone. Few patients at high risk for CVD reach LDLC goal with EZE alone, one third do with FLX and nearly 4 of 5 do so with FLX + EZE. With 1–2 million patients estimated to have discontinued statins due to MRSE, fluvastatin XL offers a readily available and effective alternative therapy. Results
Role of 18F-FDG PET/CT in the Management of a Case of Autoimmune Pancreatitis With Extrapancreatic Manifestations
Authors: Sampath Santhosh, Anish Bhattacharya, Chidambaram Natarajan Balasubramanian Harisankar, Rakesh Kochhar, Bhagwant Rai Mittal
Journal: Clinical Nuclear Medicine (2013)

Autoimmune pancreatitis and pancreatic cancer share many clinical features like advanced age, painless jaundice, weight loss, and elevated serum levels of CA 19-9. The authors report a 58-year-old male patient provisionally diagnosed with periampullary carcinoma on the basis of ultrasonography and serological markers and planned for Whipple resection. 18F-FDG PET/CT findings were suggestive of autoimmune pancreatitis, subsequently confirmed on cytological diagnosis. The follow-up PET/CT scan after 1 week of steroid therapy showed regression of FDG uptake in most of the lesions with appearance of salivary gland uptake.
Altered Expression of the Retinoblastoma Tumor-Suppressor Gene in Leukemic Cell Lines Inhibits Induction of Differentiation But Not G1-Accumulation
Authors: Gösta Bergh, Mats Ehinger, Tor Olofsson, Bo Baldetorp, Ellinor Johnsson, Helena Brycke, Gustaf Lindgren, Inge Olsson, Urban Gullberg
Journal: Blood (1997)
Brief Report: No Excess Risks in Offspring With Paternal Preconception Exposure to Disease‐Modifying Antirheumatic Drugs
Authors: Marianne Wallenius, Elisabeth Lie, Anne K. Daltveit, Kjell Å. Salvesen, Johan F. Skomsvoll, Synøve Kalstad, Åse S. Lexberg, Knut Mikkelsen, Tore K. Kvien, Monika Østensen
Journal: Arthritis & Rheumatology (2014)

To examine pregnancy outcomes in the partners of male patients with inflammatory joint disease who were or were not exposed to disease-modifying antirheumatic drugs (DMARDs) before conception compared with the outcomes in reference subjects from the general population.Linkage of data from a longitudinal observational study of patients with inflammatory joint disease (the Norwegian Disease-Modifying Antirheumatic Drug [NOR-DMARD] registry study) and the Medical Birth Registry of Norway (MBRN) enabled a comparison of pregnancy outcomes in the partners of men with inflammatory joint disease. Outcomes of pregnancies in which the father was exposed to DMARDs within 12 weeks of conception and those in which the father was never exposed to DMARDs were analyzed separately and compared with the outcomes in reference subjects. Potential associations between DMARD exposure and adverse pregnancy outcomes were assessed by logistic regression analysis.A total of 1,796 men with inflammatory joint disease were associated with 2,777 births in the MBRN. In 110 of these births, the father had been exposed to DMARDs within 12 weeks before conception, and in 230 births the father had never been exposed to DMARDs before conception. The DMARDs (monotherapy or combination treatment) to which the fathers were exposed most frequently within 12 weeks of conception were methotrexate (n = 49), sulfasalazine (n = 17), and tumor necrosis factor inhibitors (n = 57). Neither adverse pregnancy outcomes nor occurrence of congenital malformations differed between patients and reference subjects in either group.Preconception paternal exposure to DMARDs was not associated with an increase in adverse pregnancy outcomes. Importantly, no increased risk of congenital malformations was observed.
13. Selected Modification of the Adenovirus Type 5 Hexon Modulates Interaction with Coagulation Factor X and Hepatocyte Transduction In Vivo
Authors: R. Alba, Angela C. Bradshaw, Alan L. Parker, D. Bhella, Stuart A. Nicklin, Simon N. Waddington, Jerome Custers, J. Goudsmit, Nico Van Rooijen, D. H. Barouch, John H. MacVey, Andrew H. Baker
Journal: Molecular Therapy (2009)

Recent studies have demonstrated the fundamental role of coagulation factors in adenovirus infectivity in vivo. It has been shown that coagulation factor X (FX) binds to the hypervariable regions (HVR) of the adenovirus serotype 5 (Ad5) hexon with high affinity. However, a systematic analysis of binding of FX to the HVRs to identify specific domains and amino acids critical for this interaction has not been performed. Here, cryo-electron microscopy of the Ad5:FX complex at 23A was used to model the Ad5 hexon:FX interaction and identify contact residues in the hexon HVRs. In order to characterize the relative importance of these regions, we have generated novel hexon modified adenoviral vectors by homologous recombination via exchanging the hexon HVRs for those of adenoviral serotypes which do not bind FX, or by site directed mutagenesis of individual amino acids pinpointed by cryoelectron microscopy. All adenoviruses contained a CMV-lacZ reporter cassette and were amplified in HEK293 cells at similar titers to control Ad. Since the fiber and penton in each virus are identical, we assessed coxsackievirus and adenovirus receptor (CAR) dependent infection in HeLa or HepG2 cells showing all viruses transduced CAR permissive cells. Swapping either HVR5, HVR7 or both regions from adenovirus 5 to adenovirus 26 (which does not bind FX) reduced FX binding as analyzed by surface plasmon resonance, gene delivery in vitro and liver transduction in vivo. In addition, mutagenesis of amino acids in HVR5, HVR7 or both regions identified critical residues in each locale. We therefore show a critical role for HVR5 and HVR7 domains in mediating the Ad5 hexon:FX interaction. Novel Ad vectors with ablated FX interaction will be useful for future gene therapy applications where avoidance of FX-mediated effects is a key requirement.
Abstract 20432: Diagnostic Value of Cardiac Troponin T, N-Terminal Pro-Brain Natriuretic Peptide, and High-Sensitivity C-Reactive Protein During Doxorubicin Therapy in Children with Acute Lymphoblastic Leukemia
Authors: Steven E Lipshultz, Tracie L Miller, Rebecca E Scully, Stuart R Lipsitz, Nader Rifai, Lewis B Silverman, Steven D Colan, Donna S Neuberg, Suzanne E Dahlberg, Jacqueline M Henkel, Barbara L Asselin, Uma Athale, Luis A Clavell, Caroline Laverdiere, Bruno Michon, Marshall A Schorin, Stephen E Sallan
Journal: Circulation (2010)

Introduction: Doxorubicin causes cardiac injury in children with acute lymphoblastic leukemia. Measuring biomarkers during therapy might help individualize treatment by immediately identifying card...
Does aspiration have any influence on the mortality rate of patients in prolonged weaning
Authors: Markus Zenner, Daniel Meurer, Stephanie Baumann-Emmel, Miriam Brand, Mechthild Kulosa, Gabriele Rheinbay, Ute Flugel, Svetlana Velikodnaia, Jochem König, Klaus Kienast
Journal: European Respiratory Journal (2014)

BACKGROUND/AIM:  It was our hypothesis, that tracheotomised patients with long term mechanical ventilation (LTMV) and aspiration, who had been admitted to a specialised ward in order to undergo weaning from LTMV, have a higher mortality risk.   METHODS:  We used a retrospective analysis of 121 medical records from our clinic. This included files from the years 2009 till 2013. Aspiration was evidenced by Evans blue dye passing through the vocal chords (VC) and detected by an endoscope passed through the tracheostoma and directed toward the VC. The statistical analysis was done using the U-test considering the duration of LTMV, age, gender, comorbidities, and other factors. Kaplan Meier curves, Log rank test and Cox regression analysis were used to analyse survival.   RESULTS:  48/121 patients (40%) aspirated during the swallowing test (ST). 40/48 patients (83%) died within 4 years. Of the patients without aspiration during the ST 39/73 died (53%), p   CONCLUSION : This case series shows 40 % risk of aspiration in patients with LTMV. These pts have significant higher mortality after 4 years, and evidence for subsequent aspiration can be found in 83 %.
The Consult Guys - Controlling Hypertension: The Pressure Is Killing Me!
Authors: Geno J. Merli, Howard H. Weitz
Journal: Annals of Internal Medicine (2015)

Web Exclusives16 June 2015The Consult Guys - Controlling Hypertension: The Pressure Is Killing Me!FREEGeno J. Merli, MD and Howard H. Weitz, MDGeno J. Merli, MDSearch for more papers by this author and Howard H. Weitz, MDSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/G15-3006 SectionsSupplemental MaterialAboutVisual Abstract ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail The Consult Guys bring a new perspective to the art and science of medicine with lively discussion and analysis of real-world cases and situations.For more videos from and information on The Consult Guys, visit www.annals.org/ConsultGuys. Comments0 CommentsSign In to Submit A Comment Kathy SmachloCWRU University Health Service29 December 2015 one more consideration If a bruit was heard in this man, another consideration might be an aortic aneurysm. Since he is above 65 ( I don't recall his smoking history), and has hypertension, the bruit might indicate another reason for getting an ultrasound, not of the renal vessels, but of the aorta. Author, Article, and Disclosure InformationAffiliations: Disclosures: Geno J. Merli, MD, reports the following: Research grants/contracts: Bristol-Myers Squibb, Bayer, sanofi-aventis; Consultancies: Bristol-Myers Squibb, Bayer, sanofi-aventis. Howard H. Weitz, MD, reports that he has no financial relationships or interests to disclose.Editors' Disclosures: Christine Laine, MD, MPH, Editor in Chief, reports that she has no financial relationships or interests to disclose. Darren B. Taichman, MD, PhD, Executive Deputy Editor, reports that he has no financial relationships or interests to disclose. Cynthia D. Mulrow, MD, MSc, Senior Deputy Editor, reports that she has no relationships or interests to disclose. Deborah Cotton, MD, MPH, Deputy Editor, reports that she has no financial relationships or interest to disclose. Jaya K. Rao, MD, MHS, Deputy Editor, reports that she has stock holdings/options in Eli Lilly and Pfizer. Sankey V. Williams, MD, Deputy Editor, reports that he has no financial relationships or interests to disclose. Catharine B. Stack, PhD, MS, Deputy Editor for Statistics, reports that she has stock holdings in Pfizer. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byAnticoagulation? Antiplatelet? What's the Score?Jonathan Hager, MD 16 June 2015Volume 162, Issue 12Page: CG1KeywordsDisclosureHomicideHypertensionResearch grantsResearch reporting guidelines ePublished: 16 June 2015 Issue Published: 16 June 2015 Copyright & PermissionsCopyright © 2015 by American College of Physicians. All Rights Reserved.Loading ...
Medical Educators Weigh Curriculum Changes to Address Threats of Terrorism
Authors: Rebecca Voelker
Journal: JAMA (2002)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Impact of the emergence of non-vaccine pneumococcal serotypes on the clinical presentation and outcome of adults with invasive pneumococcal pneumonia
Authors: J. Burgos, V. Falcó, A. Borrego, R. Sordé, M.N. Larrosa, X. Martinez, A.M. Planes, A. Sánchez, M. Palomar, J. Rello, A. Pahissa
Journal: Clinical Microbiology and Infection (2012)
Abstract 15858: The Aquaretic Effect of Lixivaptan in Patients With Heart Failure and Volume Overload
Authors: Jalal K Ghali, Cesare Orlandi
Journal: Circulation (2011)

Introduction: Lixivaptan is a selective, orally active V2 receptor antagonist with potent aquaretic effect. Hypothesis: Patients with heart failure (HF) and volume overload will benefit from the aq...
The event-code: Not the solution to a problem, but a problem to be solved
Authors: Michael J. Richardson, Claire F. Michaels
Journal: Behavioral and Brain Sciences (2001)

We commend the argument that perception and action are tightly coupled. We claim that the argument is not new, that uniting stimulus and response codes is not a problem for a cognitive system, only for psychologists who assume them, and that the Theory of Event Coding (TEC)'s event-codes are arbitrary and ungrounded. Affordances and information offer the common basis for perception-action (and even for event-codes).
Anxiety disorders in patients with Parkinson's disease
Authors: M B Stein, I J Heuser, J L Juncos, T W Uhde
Journal: American Journal of Psychiatry (1990)

To study the prevalence and importance of anxiety disorders in patients with idiopathic Parkinson's disease, the authors systematically evaluated 24 parkinsonian patients for the presence of DSM-III-R axis I syndromes. Nine subjects (38%) had a clinically significant current anxiety disorder. Severity of anxiety was not correlated with severity of parkinsonian symptoms, cumulative duration of L-dopa exposure, or current dose of L-dopa. These findings suggest that anxiety disorders should be considered in the medical evaluation and treatment of parkinsonian patients and that further attention should be paid to the role of the dopaminergic system in anxiety and phobic disorders.
The Ig Heavy Chain Gene Is Frequently Involved in Chromosomal Translocations in Multiple Myeloma and Plasma Cell Leukemia as Detected by In Situ Hybridization
Authors: Kazuhiro Nishida, Akiko Tamura, Naozo Nakazawa, Yutaka Ueda, Tatsuo Abe, Fumihiko Matsuda, Kei Kashima, Masafumi Taniwaki
Journal: Blood (1997)
Severity of airway obstruction in overweight/obese patients with chronic obstructive pulmonary disease(COPD)
Authors: Daniel Vaz, Daniel Coutinho, Maria João Oliveira, Margarida Dias, Manuela Vanzeller, Maria Céu Brito, Teresa Shiang
Journal: European Respiratory Journal (2014)

Introduction  In COPD the prevalence of overweight/obesity can reach 54% and is associated with altered respiratory function.  Aims and objectives  Determine the prevalence of overweight/obesity in a population of COPD patients and its impact in lung function and number of exacerbations.  Methods  Age, gender, smoking habits, GOLD stage,body mass index (BMI), waist perimeter (WP), lung function parameters and number of exacerbations per year were characterized in a group of 30 COPD patients.  Results  Mean age was 67±12 years, 76,7% were male, and 83,3% had smoking habits. 13,3% were classified as GOLD A, 3,3% as GOLD B, 30% as GOLD C and 30% as GOLD D. Overall prevalence of overweight/obesity was 53,3% according to BMI≥25 kg/m2 and 66,7% according to WP≥94 cm for men and ≥80 cm for women. Patients with BMI≥25 kg/m2 had higher values for percent predicted of FEV1-%FEV1- (49,9%vs32,8%;p=0,0038) and of peak expiratory flow-PEF-(55,6%vs40,5%;p=0,043); a trend for higher percent predicted of forced vital capacity-FVC (73,2%vs65%;p=0,46) was observed. Patients with a WP defining central obesityhad higher values of %FEV1(49%vs27%;p=0,005), of PEF(56,7%vs31,4%;p=0,001) and of FVC(77,9%vs50,9%;p=0,027). Number of exacerbations per year was not different between overweight and non-overweight patients(2,4vs2;p=0,3 if BMI≥25 kg/m2; 2,2vs,2,1;p=0,8 if WP defining central obesity).  Conclusions  In this population of predominantly GOLD C and GOLD D COPD patients, those who are overweight/obese have a less severe grade of obstruction compared with non-overweight patients, suggesting a reverse epidemiology relationship between overweight/obesity and severity of airway obstruction.
Abstract 3611: Thymosin Beta-4 (TB4) Enhances Cardiosphere-derived Cardiac Stem Cell (CDC)-mediated Cardioprotection by Promoting CDC Migration and Angiogenesis via Akt Phosphorylation
Authors: Tarun Chakravarty, Satoshi Matsushita, John Terrovitis, James S Forrester, Taosheng Li, Konstantinos Malliaras, Anthony J White, Prabhav Anand, Darryl Davis, Yigiang Zhang, Rachel R Smith, Niraj Doctor, Eduardo Marban, Raj Makkar
Journal: Circulation (2009)
Psychiatric morbidity in adult inpatients with childhood histories of sexual and physical abuse
Authors: G R Brown, B Anderson
Journal: American Journal of Psychiatry (1991)

To extend the knowledge on long-term effects of childhood abuse in psychiatric patients to a large sample, the authors explored childhood sexual and physical abuse in adult inpatients over 1,040 consecutive admissions.The 947 patients were admitted to a tertiary-care military medical center. Each patient was interviewed, and abuse history, DSM-III-R diagnosis, and other characteristics were recorded.The prevalence of reported childhood abuse was 18% overall: 9% for sexual abuse (with or without physical abuse), 10% for physical abuse (with or without sexual abuse), and 3% for combined abuse. More female than male patients reported abuse. Alcohol use disorders were more common in victims of physical or combined abuse than in sexually abused or nonabused patients. Axis II diagnoses, particularly borderline personality disorder, were more frequent in abuse victims than in nonabused patients. Histories of drug and alcohol abuse were more common in patients reporting physical or combined abuse than in nonabused patients. Suicidality was also more frequent in abused than nonabused inpatients and was noted in 79% of the patients with histories of combined abuse. Combined abuse in women and physical abuse in men were associated with a family history of psychiatric illness, most commonly alcoholism in male relatives.These findings emphasize the need for greater attention to family dynamics, aggressive diagnosis and treatment of alcoholism within the family, and, especially, determination of patients' abuse histories, even if repeated questioning is necessary.