Cystatin C, Renal Function, and Cardiovascular Risk
Authors: Vandana Menon, Mark J. Sarnak, Michael G. Shlipak
Journal: Annals of Internal Medicine (2008)

Letters19 February 2008Cystatin C, Renal Function, and Cardiovascular RiskVandana Menon, MD, PhD, Mark J. Sarnak, MD, MS, and Michael G. Shlipak, MD, MPHVandana Menon, MD, PhDFrom Tufts-New England Medical Center, Boston, MA 02111, and Veterans Affairs Medical Center, San Francisco, CA 94121.Search for more papers by this author, Mark J. Sarnak, MD, MSFrom Tufts-New England Medical Center, Boston, MA 02111, and Veterans Affairs Medical Center, San Francisco, CA 94121.Search for more papers by this author, and Michael G. Shlipak, MD, MPHFrom Tufts-New England Medical Center, Boston, MA 02111, and Veterans Affairs Medical Center, San Francisco, CA 94121.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-148-4-200802190-00024 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail IN RESPONSE:Regarding our analyses examining cystatin C as a risk factor for outcomes in chronic kidney disease, we do not make the assertion that cystatin C is better than creatinine in diagnosing stage 3 kidney disease. Regarding the question about our methods, cystatin C was measured in frozen samples collected at baseline from participants of the randomized cohort of the Modification of Diet in Renal Disease Study, as stated in the Methods section. There is a precedent for using frozen stored samples to analyze cystatin C (1–3). Serum and plasma samples stored at temperatures ranging from room temperature to ...References1. Donahue RP, Stranges S, Rejman K, Rafalson LB, Dmochowski J, Trevisan M. Elevated cystatin C concentration and progression to pre-diabetes: the Western New York study. Diabetes Care. 2007;30:1724-9. [PMID: 17456840] CrossrefMedlineGoogle Scholar2. Shlipak MG, Wassel Fyr CL, Chertow GM, Harris TB, Kritchevsky SB, Tylavsky FA, et al. Cystatin C and mortality risk in the elderly: the health, aging, and body composition study. J Am Soc Nephrol. 2006;17:254-61. [PMID: 16267155] CrossrefMedlineGoogle Scholar3. Shlipak MG, Sarnak MJ, Katz R, Fried LF, Seliger SL, Newman AB, et al. Cystatin C and the risk of death and cardiovascular events among elderly persons. N Engl J Med. 2005;352:2049-60. [PMID: 15901858] CrossrefMedlineGoogle Scholar4. Kyhse-Andersen J, Schmidt C, Nordin G, Andersson B, Nilsson-Ehle P, Lindström V, et al. Serum cystatin C, determined by a rapid, automated particle-enhanced turbidimetric method, is a better marker than serum creatinine for glomerular filtration rate. Clin Chem. 1994;40:1921-6. [PMID: 7923773] CrossrefMedlineGoogle Scholar5. Finney H, Newman DJ, Gruber W, Merle P, Price CP. Initial evaluation of cystatin C measurement by particle-enhanced immunonephelometry on the Behring nephelometer systems (BNA, BN II). Clin Chem. 1997;43:1016-22. [PMID: 9191555] CrossrefMedlineGoogle Scholar Author, Article, and Disclosure InformationAffiliations: From Tufts-New England Medical Center, Boston, MA 02111, and Veterans Affairs Medical Center, San Francisco, CA 94121.Disclosures: None disclosed. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoCystatin C as a Risk Factor for Outcomes in Chronic Kidney Disease Vandana Menon , Michael G. Shlipak , Xuelei Wang , Josef Coresh , Tom Greene , Lesley Stevens , John W. Kusek , Gerald J. Beck , Allan J. Collins , Andrew S. Levey , and Mark J. Sarnak Cystatin C, Renal Function, and Cardiovascular Risk Pierre Delanaye , Etienne Cavalier , and Jean-Marie Krzesinski Metrics 19 February 2008Volume 148, Issue 4Page: 324KeywordsBody mass indexCardiovascular disease riskChronic kidney diseaseCohort studiesCreatinineMedical risk factorsRenal analysisRenal diseasesRisk managementTemperature ePublished: 19 February 2008 Issue Published: 19 February 2008 CopyrightCopyright © 2008 by American College of Physicians. All Rights Reserved.PDF DownloadLoading ...