Hemoglobin M—An Early Chapter in the Saga of Molecular Pathology
Authors: PAUL HELLER
Journal: Annals of Internal Medicine (1969)

Editorials1 May 1969Hemoglobin M—An Early Chapter in the Saga of Molecular PathologyPAUL HELLER, M.D., F.A.C.P.PAUL HELLER, M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-70-5-1038 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptIn 1947 a meeting of the Westphalian Society for Internal Medicine in Duesseldorf was presented with a remarkable paper by a young physician and a medical student, Hoerlein and Weber, who reported their study of a family with "chronic familial methemoglobinemia and a new modification of methemoglobin" (1). The first member of this family known to have "a special kind of cyanosis" was a woman born soon after 1800 who reached the age of 84 years. Two of her sons and five of her grandchildren and great grandchildren also had cyanosis. The latter lived under the professionally sanctioned impression that...References1. HOERLEINWEBER MG: Ueber chronische familiare Methaemoglobinaemie und eine nene Modifikation des Methaemoglobins. Deutsch. Med. Wschr. 73: 476, 1948. CrossrefMedlineGoogle Scholar2. PAULINGITANOSINGERWELLS LHASJIC: Sickle cell anemia, a molecular disease. Science 110: 543, 1949. CrossrefMedlineGoogle Scholar3. SINGER K: Hereditary hemolytic disorders associated with abnormal hemoglobins. Amer. J. Med. 18: 633, 1955. CrossrefMedlineGoogle Scholar4. JAFFEHELLER ERP: Methemoglobinemia in man, in Progress in Hematology, vol. 4, Grune & Stratton, Inc., New York, 1964, p. 48. Google Scholar5. GERALD PS: The electrophoretic and spectroscopic characterization of hgb M. Blood 13: 936, 1958. CrossrefMedlineGoogle Scholar6. GERALDEFRON PSML: Chemical studies of several varieties of hemoglobin M. Proc. Nat. Acad. Sci. 47: 1758, 1961. CrossrefMedlineGoogle Scholar7. SHIBATAMIYAJIIUCHIOHBAYAMAMOTO STIYK: Hemoglobin M's of the Japanese. Bull. Yamaguchi Med. School 14: 141, 1967. Google Scholar8. SHIBATATAMURAIUCHITAKAHASHI SAH: Hemoglobin M.: demonstration of a new abnormal hemoglobin in hereditary nigremia. Acta Haemat. Jap. 23: 96, 1960. MedlineGoogle Scholar9. PERUTZMUIRHEADCOXGOAMAN MFHJMLC: Three dimensional Fourier synthesis of horse oxyhemoglobin at 2.8 A° resolution: the atomic model. Nature (London) 219: 131, 1968. CrossrefMedlineGoogle Scholar10. PERUTZLEHMANN MFH: Molecular pathology of human haemoglobin. Ibid., p. 902. Google Scholar11. HELLER P: Hemoglobinopathic dysfunction of the red cell. Amer. J. Med. 41: 799, 1966. CrossrefMedlineGoogle Scholar12. HAYASHIMOTOKAWAKIKUCHI NYG: Studies on relationships between structure and function of hemoglobin MIwate. J. Biol. Chem. 241, 79, 1966. CrossrefMedlineGoogle Scholar13. RANNEYNAGELHELLERUDEM HMRLPL: Oxygen equilibrium of hemoglobin MHyde Park. Biochem. Biophys. Acta 160: 112, 1968. MedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByLinus Pauling's ?molecular diseases?: Between history and memoryHistoric Reflections on the Clinical Roots of Molecular BiologyGenetic DiseaseSeparation of α- and β-chains of hemoglobin A by acetyl-phenylhydrazineHaemoglobin M Saskatoon and Haemoglobin M Hyde Park in Two Yugoslavian FamiliesHaemoglobin M Saskatoon with Slight Constant Haemolysis, Markedly Increased by SulphonamidesThree-dimensional structure of abnormal human haemoglobins M Hyde Park and M Iwate 1 May 1969Volume 70, Issue 5Page: 1038-1041KeywordsHemoglobinMethemoglobinMethemoglobinemiaMolecular pathology Issue Published: 1 May 1969 PDF DownloadLoading ...