SERUM TRANSAMINASE IN PULMONARY DISEASE AND MULTIPLE INFARCTIONS
Authors: J R WALSH, F L HUMOLLER, F G GILLICK
Journal: Annals of Internal Medicine (1957)

Article1 June 1957SERUM TRANSAMINASE IN PULMONARY DISEASE AND MULTIPLE INFARCTIONSJOHN R. WALSH, M.D., FRED L. HUMOLLER, Ph.D., FREDERICK G. GILLICK, M.D., F.A.C.P.JOHN R. WALSH, M.D.Search for more papers by this author, FRED L. HUMOLLER, Ph.D.Search for more papers by this author, FREDERICK G. GILLICK, M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-46-6-1105 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptIn 1954 LaDue and collaborators1reported on the value of the serum transaminase (SGO-T) level as a diagnostic measure for acute myocardial infarction. Since that time this test has become as popular as the electrocardiogram in studies of patients suspected of this disorder. Elevations of the SGO-T have been found in a high percentage of patients with acute myocardial infarction.2-4It was anticipated that this test would provide a method for differentiating myocardial infarction from disorders simulating it, such as pancreatitis, pulmonary infarction and coronary insufficiency. However, subsequent studies have indicated that the SGO-T test is less specific than was...Bibliography1. LaDueWroblewskiKarmen JSFA: Serum glutamic oxaloacetic transaminase activity in human acute transmural myocardial infarction, Science 120: 497, 1954. CrossrefMedlineGoogle Scholar2. LaDueWroblewski JSF: The significance of serum glutamic oxalacetic transaminase activity following acute myocardial infarction, Circulation 11: 871, 1955. CrossrefMedlineGoogle Scholar3. ChinskyShmagranoffSherry MGLS: Serum transaminase activity, J. Lab. and Clin. Med. 47: 108, 1956. MedlineGoogle Scholar4. KattusWatanabeSemensonDrell AARCW: Serum aminopherase (transaminase) in diagnosis of acute myocardial infarction, J. A. M. A. 160: 16, 1956. CrossrefMedlineGoogle Scholar5. WroblewskiLaDue FJS: Serum glutamic oxalacetic transaminase activity as an index of liver cell injury: a preliminary report, Ann. Int. Med. 43: 345, 1955. LinkGoogle Scholar6. MolanderWroblewskiLaDue DWFJS: Serum glutamic oxalacetic transaminase as an index of hepatocellular integrity, J. Lab. and Clin. Med. 46: 831, 1955. MedlineGoogle Scholar7. WroblewskiLaDue FJS: Serum glutamic-oxalacetic-transaminase activity as an index of liver-cell injury from cancer, Cancer 8: 1155, 1955. CrossrefMedlineGoogle Scholar8. RuskinMahaffeyRuskin AWCB: Serum glutamic oxalacetic transaminase, Clin. Res. Proc. 4: 30, 1956. Google Scholar9. NydickTangStollermanWroblewskiLaDue IJGHFJS: The influence of rheumatic fever on serum concentrations of the enzyme, glutamic oxalacetic transaminase, Circulation 12: 795, 1955. CrossrefMedlineGoogle Scholar10. RudolphDuttonSchaefer LARJA: Glutamic oxalacetic transaminase levels in experimental tissue damage, J. Clin. Investigation 34: 960, 1955. Google Scholar11. CohenHekhuis PPLG: Rate of transamination in normal tissues, J. Biol. Chem. 140: 711, 1941. CrossrefGoogle Scholar12. AwaperaSeale JB: Distribution of transaminases in rat organs, J. Biol. Chem. 194: 497, 1952. CrossrefMedlineGoogle Scholar13. KarmenWroblewskiLaDue AFJS: Transaminase activity in human blood, J. Clin. Investigation 34: 126, 1955. CrossrefMedlineGoogle Scholar14. AgressJacobsGlassnerLedererClarkWroblewskiKarmenLaDue CMHIHFMAWGFAJS: Serum transaminase levels in experimental myocardial infarction, Circulation 11: 711, 1955. CrossrefMedlineGoogle Scholar15. GoldsteinIsraelSeligson FHLD: Use of serum transaminase levels in the differentiation of pulmonary embolism and myocardial infarction, New England J. Med. 254: 746, 1956. CrossrefMedlineGoogle Scholar16. OstrowPolisEvans BHGNJM: Serum glutamic oxalacetic transaminase (GOT) in pulmonary embolization, Clin. Res. Proc. 4: 155, 1956. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: JOHN R. WALSH, M.D.; FRED L. HUMOLLER, Ph.D.; FREDERICK G. GILLICK, M.D., F.A.C.P.Affiliations: Omaha, Nebraska*Received for publication August 24, 1956.From the Medical Service and Medical Research Laboratory, Veterans Administration Hospital, University of Nebraska College of Medicine, and the Creighton University School of Medicine, Omaha, Nebraska.This work was supported in part by a grant from the Nebraska Heart Association through Creighton University School of Medicine (Dr. Gillick).Requests for reprints should be addressed to John R. Walsh, M.D., Veterans Administration Hospital, 4104 Woolworth Avenue, Omaha 5, Nebraska. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited by1 Clinical EnzymologyThe use of cellulose acetate for the electrophoretic separation and quantitation of serum lactic dehydrogenase isozymes in normal and pathologic statesThe Importance of the Measurement of Enzyme Activity in MedicineAlterations in indices of liver function in congestive heart failure with particular reference to serum enzymesSerum transaminase in liver disorders its relation to hepatic efficiency testsINCREASING CLINICAL SIGNIFICANCE OF ALTERATIONS IN ENZYMES OF BODY FLUIDS*FELIX WRÓBLEWSKI, M.D.Evaluation of the transaminase testUsefulness and Limitations of Determinations of Serum Transaminase in the Diagnosis of Acute Myocardial InfarctionSerum transaminase and other enzymes in acute myocardial infarctionCase 43351 1 June 1957Volume 46, Issue 6 Page: 1105-1112 Keywords Aminotransferases Hospital medicine Infarction Medical services Myocardial infarction Necrosis Pancreatitis Pneumonia Pulmonary diseases Research laboratories ePublished: 1 December 2008 Issue Published: 1 June 1957 PDF downloadLoading ...