tbuckley/cabot-search huggingface dataset:
The Matter of Venereal Disease in 1971
Authors: R. H. KAMPMEIER
Journal: Annals of Internal Medicine (1971)

Editorials1 November 1971The Matter of Venereal Disease in 1971R. H. KAMPMEIER, M.D.R. H. KAMPMEIER, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-75-5-793 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptIt is not news that venereal disease is a problem for the world and specifically for this country. A recent editorial (1) in theJournal of the American Medical Associationsuccinctly recounted the stark facts documented in the annual report of the American Social Health Association (2). For the year ending June 1970, the rate for infectious syphilis had risen by 8% over the year before, and gonorrhea had risen 16%. There is evidence that only 12% of the 80% of patients treated for venereal disease by private physicians are reported; therefore it is estimated that in 1970 treatment was...References1. BARTON F: Venereal disease (editorial). JAMA 215:1472-1473, 1971 CrossrefGoogle Scholar2. Today's VD Control Problem-1971. Annual report of the American Public Health Association and the American Venereal Disease Association. New York, American Social Health Association, 1971 Google Scholar3. BROWN W: Eradication of syphilis: the missing element (editorial). Ann Intern Med 72:278-280, 1970 LinkGoogle Scholar4. BROWN W: Gonorrhea: not yet controllable (editorial). Ibid., pp. 280-281 Google Scholar5. WEBSTER B: Teaching of venereal disease in medical schools throughout the world. Preliminary report. Br J Vener Dis 42:132-133, 1966 MedlineGoogle Scholar6. WEBSTER B: Teaching of the clinical, epidemiological, public health and social aspects of the venereal diseases in the medical schools throughout the world. Interim report of the continuing cooperative study between WHO and the IUVDT. Br J Vener Dis 46:156-158, 1970 MedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Vanderbilt University School of Medicine Nashville, Tenn. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited bySexually transmissible diseasesThe epidemiology and control of gonorrhea and syphilis: A reappraisal 1 November 1971Volume 75, Issue 5Page: 793-795KeywordsGonorrheaSexually transmitted diseasesSyphilis Issue Published: 1 November 1971 PDF downloadLoading ...
PERICARDIAL EFFUSIONS IN PULMONARY HYPERTENSION: PRESENTATION, PREDICTORS &amp;amp; OUTCOMES
Authors: Hemant Boolani, Madhu Reddy, Sowjanya Duthuluru, Timothy Williamson, Leslie Spikes, Namratha Reddy, Sudharani Bommana, Donita Atkins, Jayasree Pillarisetti, Buddhadeb Dawn, Jayant Nath, Dhanunjaya Lakkireddy
Journal: Journal of the American College of Cardiology (2012)
Left Ventricular Aneurysm
Authors: Kim Eagle, Rajendra Patel, Mohandas M. Shenoy
Journal: New England Journal of Medicine (1993)

Figure 1. Left Ventricular Aneurysm. The images show the results of contrast left ventriculography in a 72-year-old woman who presented with progressive cardiac failure after myocardial infarction. Panel A is a right anterior oblique view showing the left ventricle during systole. The contrast medium was injected through an angiographic catheter (arrow) passed into the left ventricle in a retrograde fashion from the aorta (AO). A large ventricular aneurysm (AN) is located at the apex of the left ventricle. The stasis of blood in the aneurysm is revealed by the contrast density, which is greater in the aneurysm than in the . . .
Lyme disease with facial nerve palsy: rapid diagnosis using a nested polymerase chain reaction–restriction fragment length polymorphism analysis
Authors: None Hashimoto, None Takahashi, None Kishiyama, None Sato, None Nakao, None Miyamoto, None Iizuka
Journal: British Journal of Dermatology (1998)

A 64-year-old woman with Lyme disease and manifesting facial nerve palsy had been bitten by a tick on the left frontal scalp 4 weeks previously. Erythema migrans appeared on the left forehead, accompanied by left facial paralysis. Nested polymerase chain reaction–restriction fragment length polymorphism analysis (nested PCR–RFLP) was performed on DNA extracted from a skin biopsy of the erythema on the left forehead. Borrelia flagellin gene DNA was detected and its RFLP pattern indicated that the organism was B. garinii. Five weeks later, B. garinii was isolated by conventional culture from the erythematous skin lesion, but not from the cerebrospinal fluid. After treatment with ceftriaxone intravenously for 10 days and oral administration of minocycline for 7 days, both the erythema and facial nerve palsy improved significantly. Nested PCR and culture taken after the lesion subsided, using skin samples obtained from a site adjacent to the original biopsy, were both negative. We suggest that nested PCR–RFLP analysis might be useful for the rapid diagnosis of Lyme disease and for evaluating therapy.
Collaborative research networks work
Authors: Anamaria A. Camargo, Andrew J.G. Simpson
Journal: Journal of Clinical Investigation (2003)

Brazil was heralded for completion of the first genome sequence of a plant pathogen following the development of a virtual research center - a collaborative network of laboratories throughout the state of São Paulo, drawing on the expertise of a dispersed and diverse scientific community and on investment from both the government and the private sector. Strategies key to the success of this model are discussed here in the context of continuing collaborative scientific endeavors in both developed and developing countries.
Effects of corticosteroids on the proliferation of normal and abnormal human connective tissue cells
Authors: G. C. PRIESTLEY, J. C. BROWN
Journal: British Journal of Dermatology (1980)

Four corticosteroids were tested in vitro for effect on the proliferation of four strains of fibroblasts from scleroderma skin, four strains from normal adult skin and four strains of rheumatoid synovial cells. Significant effects on fibroblasts occurred only at the highest steroid concentration tested (10 μg/ml) where the inhibitory ranking of the steroids was clobetasol propionate > clobetasone butyrate > betamethasone valerate > hydrocortisone. Hydrocortisone and betamethasone valerate stimulated proliferation of two normal strains, had no certain effect on the scleroderma group, and inhibited growth of synovial cells. Clobetasone butyrate and clobetasol propionate inhibited growth of all cells. All four steroids substantially reduced acid mucopolysaccharide secretion by scleroderma fibroblasts. These results suggest that fibroblasts from normal and abnormal skin show only small differences in their responses to corticosteroids in vitro, but contrast sharply with the mouse L‐929 fibroblasts previously used in some assays of topical corticosteroid potency.
Oxygen toxicity and iron accumulation in the lungs of mice lacking heme oxygenase-2.
Authors: P A Dennery, D R Spitz, G Yang, A Tatarov, C S Lee, M L Shegog, K D Poss
Journal: Journal of Clinical Investigation (1998)

Heme oxygenase (HO) activity leads to accumulation of the antioxidant bilirubin, and degradation of the prooxidant heme. Moderate overexpression of the inducible form, HO-1, is associated with protection against oxidative injury. However, the role of HO-2 in oxidative stress has not been explored. We evaluated survival, indices of oxidative injury, and lung and HO expression in HO-2 null mutant mice exposed to > 95% O2 compared with wild-type controls. Similar basal levels of major lung antioxidants were observed, except that the knockouts had a twofold increase in total glutathione content. Despite increased HO-1 expression from HO-1 induction, knockout animals were sensitized to hyperoxia-induced oxidative injury and mortality, and also had significantly increased markers of oxidative injury before hyperoxic exposure. Furthermore, during hyperoxia, lung hemoproteins and iron content were significantly increased without increased ferritin, suggesting accumulation of available redox-active iron. These results demonstrate that the absence of HO-2 is associated with induction of HO-1 and increased oxygen toxicity in vivo, apparently due to accumulation of lung iron. These results suggest that HO-2 functions to augment the turnover of lung iron during oxidative stress, and that this function does not appear to be compensated for by induction of HO-1 in the knockouts.
Surgeon is struck off for failing to mention disciplinary action
Authors: Owen Dyer
Journal: BMJ (2005)

A surgeon who failed to mention his suspension in the United Kingdom on his application for an American licence to practise has been struck off for dishonesty.

Mahesh Goel received a one year suspension from the General Medical Council 12 months ago for inadvertently removing the only healthy kidney of a patient who later died. He would have been eligible to resume work this month, but a GMC review hearing heard that Mr Goel had falsely answered a question about previous suspensions on a licence application form sent to the West Virginia Board of Medicine.

Mr Goel's original suspension arose from the death of …
Brominated Flame Retardants in North-East Atlantic Marine Ecosystems
Authors: Bjørn Munro Jenssen, Eugen G. Sørmo, Kine Bæk, Jenny Bytingsvik, Hege Gaustad, Anders Ruus, Janneche Utne Skaare
Journal: Environmental Health Perspectives (2007)

Concentrations of brominated flame retardants (BFRs) are reported to increase in marine ecosystems.Characterize exposure to BFRs in animals from different trophic levels in North-East Atlantic coastal marine ecosystems along a latitudinal gradient from southern Norway to Spitsbergen, Svalbard, in the Arctic. Calanoid species were collected from the Oslofjord (59 degrees N), Froan (64 degrees N), and Spitsbergen (> 78 degrees N); Atlantic cod (Gadus morhua) from the Oslofjord and Froan; polar cod (Boreogadus saida) from Bear Island (74 degrees N) and Spitsbergen; harbor seal (Phoca vitulina) from the Oslofjord, Froan, and Spitsbergen; and ringed seal (Phoca vitulina) from Spitsbergen. Eggs of common tern (Sterna hirundo) were collected from the Oslofjord, and eggs of arctic terns (Sterna paradisaea) from Froan and Spitsbergen.Levels of polybrominated diphenylethers (PBDEs) and hexabromocyclododecane (HBCD) generally decreased as a function of increasing latitude, reflecting distance from release sources. The clear latitudinal decrease in levels of BFRs was not pronounced in the two tern species, most likely because they are exposed during migration. The decabrominated compound BDE-209 was detected in animals from all three ecosystems, and the highest levels were found in arctic tern eggs from Spitsbergen. HBCD was found in animals from all trophic levels, except for in calanoids at Froan and Spitsbergen.Even though the levels of PBDEs and HBCD are generally low in North-East Atlantic coastal marine ecosystems, there are concerns about the relatively high presence of BDE-209 and HBCD.
Diminished spectrin extraction from ATP-depleted human erythrocytes. Evidence relating spectrin to changes in erythrocyte shape and deformability.
Authors: S E Lux, K M John, T E Ukena
Journal: Journal of Clinical Investigation (1978)

We measured spectrin "extractability" in erythrocytes which were metabolically depleted by incubation at 37 degrees C in plasma or glucose-free buffers. Membranes were extracted with 1 mM EDTA (pH 8, 40 h, 4 degrees C) and analyzed by polyacrylamide gel electrophoresis in sodium dodecyl sulfate. This procedure solubilized 85--90% of the spectrin, actin, and residual hemoglobin from ghosts of fresh erythrocytes. In incubated erythrocytes, inextractable spectrin rapidly accumulated when ATP concentrations fell below 0--15% of normal. In severely depleted cells, 60--90% of the total ghost spectrin became inextractable. Inextractability was not abolished by physically disrupting the ghost before extraction, but was reversed when erythrocyte ATP was replenished with adenosine. The accumulation of inextractable spectrin correlated temporally with the increase in apparent membrane deformability and the increases in erythrocyte vicosity, calcium content, sodium gain, and potassium loss characteristic of ATP-depleted erythrocytes. No change in integral membrane protein topography (assessed by the distribution of intramembranous particles and concanavalin A surface-binding sites) was detected in depleted cells. Analogous changes were observed in erythrocytes exposed to extremes of pH and temperature. When the pH in the erythrocyte interior fell below 5.5, a pH where spectrin was aggregated and isoelectrically precipitated, erythrocyte and ghost viscosity increased coincident with a marked decrease in spectrin extractability. Similarly above 49 degrees C, a temperature where spectrin was denatured and precipitated, erythrocyte viscosity rose as inextractable spectrin accumulated. These observations provide direct evidence of a change in the physical state of spectrin associated with a change in erythrocyte shape and deformability. They support the concept that erythrocyte shape and deformability are largely determined by the shape and deformability of the spectrin-actin protein meshwork which laminates the inner membrane surface.
76. In Vivo Suppression of Cytotoxic T Cell Responses by CD4+ Regulatory T Cells Activated by Hepatic Gene Transfer
Authors: Lixin Wang, Eric Dobrzynski, Julie Fitzgerald, Ou Cao, Roland W. Herzog
Journal: Molecular Therapy (2006)

Treatment of genetic disease such as the bleeding disorder hemophilia B (deficiency in blood coagulation factor IX, F.IX) by gene replacement therapy is complicated by the risk of immune responses to the therapeutic gene product and to the gene transfer vector. Previously, we have shown that adeno-associated viral (AAV) hepatic gene transfer can induce immune tolerance to F.IX. Immune competent mice of two different strains (BALB/c and C3H) were tolerized to human F.IX by this protocol. These animals were subsequently challenged by systemic administration of an E1/E3- deleted adenoviral vector (Ad-hF.IX), which is known to induce a cytotoxic T lymphocyte (CTL) response to the transgene product. Immune tolerance prevented CTL activation to F.IX (as determined by in vitro CTL assay) and CD8+ cellular infiltrates in the liver, and also reduced antibody formation to F.IX to low and transient responses. Moreover, a sustained (≥4 months) and substantial increase in hepatic F.IX expression from the adenoviral vector was achieved (increase from 0.2 to 1–2 μg/ml plasma and from 3–5% of hepatocytes to 20–50%) despite in vitro T cell responses to adenoviral antigens. This suggested an in vivo suppression mechanism. Interestingly, splenocytes from tolerized mice had increased proportions of CD4+CD62L+ and of CD4+CD25+GITR+ cells, and CD4+ splenocytes had increased levels of FoxP3 mRNA. This suggested a complex regulatory mechanism that included cells with a phenotype similar to naturally occuring regulatory CD4+ T cells. To test our suppression hypothesis, splenocytes were adoptively transferred from tolerized C3H/HeJ mice (6 weeks after hepatic AAV gene transfer) to naive C3H/HeJ mice. The following day, Ad-hF.IX was systemically administered to recipient mice (n=4/ experimental group). Compared to CD4-depleted cells and to splenocytes from naive controls, CD4+ cells from AAV-hF.IX hepatic transduced animals (1x10exp6 per recipient mouse) suppressed anti-hF.IX formation and inflammatory lymphocyte responses to Ad-hF.IX transduced liver. Consequently, prolonged hepatic and systemic hF.IX expression was observed (1–2% hF.IX positive hepatocytes for ≥2 months vs. <0.1% in control groups), and hepatic injury normally caused by the response to adenovirus was limited. CD4- cells failed to suppress these immune responses. Therefore, regulatory CD4+ T cells activated by hepatocyte-derived hF.IX expression can suppress responses to viral antigens expressed in the context of hF.IX. These results indicate that augmentation of regulatory CD4+ T cell activation should provide new means to avoid destructive immune responses to therapeutic and viral antigens in gene transfer.
Mechanical Lithotripsy of Bile Duct Stones in 209 Patients-Effect of Technical Advances
Authors: M. U. Schneider, W. Matek, R. Bauer, W. Domschke
Journal: Endoscopy (1988)

Between 1982 and 1987, mechanical lithotripsy of common bile duct (CBD) stones was performed in 209 patients (mean age ± SD: 72 ± 10 years), using self-constructed lithotripters and baskets with breaking strengths of approximately 50 and 100 kg between 1982 and 1986, and stronger and bigger baskets with breaking strengths of approximately 125 kg since 1987. Patients with single (49.3 %) and multiple stones (50.7 %) were distributed about equally. Stone size ranged between 4 and 80 mm (mean longitudinal diameter 18 ± 9 mm, mean transversal diameter 13 ± 3 mm), with a majority of the patients (61.2 %) having stones of between 10 and 19 mm, and about one-third (32.1 %) of the patients with stones ≥ 20 (20-80) mm.
The effect of hemodialysis on protein metabolism. A leucine kinetic study.
Authors: V S Lim, D M Bier, M J Flanigan, S T Sum-Ping
Journal: Journal of Clinical Investigation (1993)

To assess the effect of hemodialysis on protein metabolism, leucine flux was measured in seven patients before, during, and after high efficiency hemodialysis using cuprophane dialyzers and bicarbonate dialysate during a primed-constant infusion of L-[1-13C]leucine. The kinetics [mumol/kg per h, mean +/- SD] are as follows: leucine appearance into the plasma leucine pool was 86 +/- 28, 80 +/- 28, and 85 +/- 25, respectively, before, during, and after dialysis. Leucine appearance into the whole body leucine pool, derived from plasma [1-13C]alpha-ketoisocaproate enrichment, was 118 +/- 31, 118 +/- 31, and 114 +/- 28 before, during, and after dialysis, respectively. In the absence of leucine intake, appearance rate reflects protein degradation, which was clearly unaffected by dialysis. Leucine oxidation rate was 17.3 +/- 7.8 before, decreased to 13.8 +/- 7.8 during, and increased to 18.9 +/- 10.3 after dialysis (P = 0.027). Leucine protein incorporation was 101 +/- 26 before, was reduced to 89 +/- 23 during, and returned to 95 +/- 23 after dialysis (P = 0.13). Leucine net balance, the difference between leucine protein incorporation and leucine release from endogenous degradation, was -17.3 +/- 7.8 before, decreased to -28.5 +/- 11.0 during, and returned to -18.9 +/- 10.3 after dialysis (P < 0.0001). This markedly more negative leucine balance during dialysis was accountable by dialysate leucine loss, which was 14.4 +/- 6.2 mumol/kg per h. These data suggest that hemodialysis using a cuprophane membrane did not acutely induce protein degradation. It was, nevertheless, a net catabolic event because protein synthesis was reduced and amino acid was lost into the dialysate.
The Incidence of Multiple Lesions in Primary Syphilis
Authors: Ivan W. Kuhl, Hunter Boggs
Journal: New England Journal of Medicine (1948)

ONE of the most popular misconceptions of the medical profession is that the primary lesion of syphilis is always single. In fact, many physicians have been known to eliminate syphilis as a part of the differential diagnosis because the genital lesions were multiple, not single. In our medical-school experience and that of our immediate acquaintances of the medical profession the impression was given that multiple primary lesions in syphilis are rare (in the dozen or so medical schools attended). Medical students and general practitioners can hardly be blamed, since authoritative authors such as Stokes et al.,1 Sutton and Sutton2 and . . .
Myocardial Contrast Echocardiography in Acute Myocardial Infarction Using Aortic Root Injections of Microbubbles in Conjunction With Harmonic Imaging: Potential Application in the Cardiac Catheterization Laboratory
Authors: Christian Firschke, Jonathan R Lindner, Norman C Goodman, Danny M Skyba, Kevin Wei, Sanjiv Kaul
Journal: Journal of the American College of Cardiology (1997)
The Doctor Stories
Authors: Iain McClure
Journal: BMJ (2007)

William Carlos Williams (1883-1963) made his living as a doctor and his reputation as a writer. After initial training in New York he worked as a family practitioner in his home town of Rutherford, New Jersey, for 40 years, seeing—in his own estimation—a million and a half patients. His formative working life was spent during the Depression, his patients being mainly blue-collar workers and the unemployed underclass. Many were immigrants who spoke little or no English, and a chronic feature of his consultations was their struggle to pay …
Why do we need to coordinate when classifying kin?
Authors: Drew Gerkey, Lee Cronk
Journal: Behavioral and Brain Sciences (2010)

Abstract We suggest that there are two coordination games when it comes to understanding kin terminology. Jones' article focuses on the linguistic coordination inherent in developing meaningful kin terminologies, alluding briefly to the benefits of these kin terminologies for coordination in other domains. We enhance Jones' discussion by tracing the links between the structure of kin terminologies and their functions.
John Bernard Fox
Authors: Mary Polkinhorn
Journal: BMJ (2006)

Former consultant radiologist Counties Sligo, Leitrim, Longford, and South Donegal (b 1920; q University College Dublin 1946; DRMD), d 12 April 2006.

John had to spend a year or more as a patient with pulmonary tuberculosis at Peamount Hospital, West Dublin, during his studies. This experience helped to develop his taste for the camaraderie of hospital life and interest in chest radiography, then the backbone of radiology services. He took the diploma in radiological diagnosis at the University of Bristol. From 1952 to 1955 he was assistant medical director of the National Mass Radiography Association in Ireland, before becoming consultant radiologist to Counties Sligo, Leitrim, Longford, and South Donegal, where he remained for the rest of his professional life. Predeceased in 2003 by his wife, Caimin, he leaves five children and 10 grandchildren.
Prosecution or persecution?
Authors: K. Karunaratne
Journal: BMJ (2002)

It was a typically busy night in the regional neonatal intensive care unit. The nursing staff informed a junior doctor that an infant's intravenous cannula had “tissued.” The doctor inserted a new cannula but, on attempting to flush the cannula with water, it was obvious that the cannula had been sited extravascularly.

> Crucial statements were littered with inaccuracies, inconsistencies, and blatant errors of fact 

While the doctor collected equipment for another cannulation attempt, the infant had a profound cardiorespiratory collapse from which he could not be resuscitated. An opened ampoule of intravenous phenytoin, intended for another patient, was found near to the deceased infant, raising the dreadful possibility that an erroneous administration of phenytoin had contributed to the infant's death.

> Let us hope that the CPS will never again attempt to destroy the career of an innocent doctor 

The doctor who had attempted to replace the intravenous cannula was immediately suspended. The coroner …
Risk Assessment of Prostatic Pathology in Patients Undergoing Radical Cystoprostatectomy
Authors: Joseph A. Pettus, Hikmat Al-Ahmadie, Daniel A. Barocas, Theresa M. Koppie, Harry Herr, S. Machele Donat, Guido Dalbagni, Victor E. Reuter, Semra Olgac, Bernard H. Bochner
Journal: European Urology (2007)