tbuckley/cabot-search huggingface dataset:
Abstract 18639: Clinical Impact of Implantable Loop Recorders on Management of Patients with Recurrent Syncope and Cryptogenic Cerebrovascular Accident
Authors: Ajay Abichandani, Huseng Vefali, David Signarovitz, Lakshmi Chebrolu, Jamshid Shirani, Darren Traub
Journal: Circulation (2014)

Introduction:  Implantable loop recorder (ILR) - a small leadless subcutaneous device with two electrodes - can be used for long-term electrocardiographic (ECG) monitoring. The device can be triggered manually or follow preset arrhythmia algorithms. Current guidelines recommend utilization of ILR in ambulatory settings for patients with recurrent syncope or cryptogenic stroke. We present our initial experience with such a device (Medtronic Reveal XT 9529).   Methods:  Over a 36-month period, 34 adults (mean age 61±18 years, 53% men) with recurrent unexplained syncope [n=28 (82%)] or cryptogenic stroke [n=6 (18%)], following an inconclusive clinical work-up, underwent ILR implantation. Clinical and demographic data as well as all patient and-auto-triggered ECG data were reviewed over an average follow up period of 32 (range 14-55) months.    Results:  Workup prior to implantation included 12-lead ECG and telemetry data (100%), transthoracic echocardiogram (97%), transesophageal echocardiogram (2.9%), electroencephalogram (10%), 24-hour ambulatory ECG monitor (23.5%), tilt table test (14.7%), computed tomographic imaging of the head (11.7%), pharmacologic (regadenosan) myocardial perfusion imaging (14.7%), carotid ultrasound (26.9%), invasive electrophysiology study (8.8%), and magnetic resonance imaging of the brain (2.9%). During the follow up period, an etiology for recurrent syncope was identified in 28.6% (8/28) and previously unsuspected paroxysmal atrial fibrillation was found in 33% (2/6) of patients with cryptogenic stroke. The findings resulted in a change in the clinical management of 10 of 34 (29.4%) patients including pacemaker implantation for bradyarrhythmias in 11.7% (4/34), radiofrequency ablation for atrioventricular node reentrant tachycardia in 2.9% (1/34), and initiation of anticoagulation therapy in 11.7% (4/34). No complication was associated with these implantable devices.   Conclusions:  ILR is a safe and effective means of determining the etiology of recurrent unexplained syncope and identifying paroxysmal atrial fibrillation as a potential cause of cryptogenic stroke.
Abstract 2002: 22q11.2 Deletion Status and the Risk of Aortic Root Dilation in Pediatric Patients With Tetralogy of Fallot
Authors: Anitha S John, Jack Rychik, Wei Yang, Elizabeth Goldmuntz
Journal: Circulation (2009)

Background: Reported risk factors for aortic root dilation (ARD) in tetralogy of Fallot (TOF) include right aortic arch and pulmonary valve atresia, features seen in 22q11.2 deletion syndrome. This...
Fear of Frying
Authors: Mike Mitka
Journal: JAMA (2002)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Abstract 39: Added Sugar Intake and Lipids Profile Among US Adolescents: NHANES 2005-2010
Authors: Zefeng Zhang, Cathleen Gillespie, Frank Hu, Quanhe Yang
Journal: Circulation (2014)

Background: Studies suggest that higher consumption of added sugar is associated with cardiovascular risk factors in adolescents. However, these studies were subject to measurement error due to the lack of adjustment for day-to-day variability. Hypothesis: We hypothesized that higher usual percent of calories from added sugar is associated with dyslipidemia. Methods: We analyzed data on 3322 adolescents aged 12-19 years who were not on low fat/low cholesterol diet or on sugar free/low sugar diet from the 2005-2010 National Health and Nutrition Examination Surveys. We estimated the usual percent of calories from added sugar from the diet accounting for measurement error. Multivariable linear regression was used to examine the associations between the percent of calories from added sugar with lipids profile. Results: The average usual percent of calories from added sugar was 17.5%. Ninety-one percent and 11% adolescents had usual percent ≥10% and ≥25%, respectively. After adjustment for potential confounders (age, sex, race/ethnicity, body mass index, parental educational attainment, smoking status, physical activity, 2010 Health Eating Index score except sugar component, and total calorie intake), usual percent of calories from added sugar was inversely associated with high-density lipoprotein and positively associated with triglycerides and the ratio of total cholesterol to high-density lipoprotein. Among the lowest and the highest quintiles of intake, high-density lipoprotein were 52.4 mg/dL (95% CI: 50.9 to 53.9) and 49.0 (95% CI: 47.9 to 50.2) (P trend = 0.003), triglycerides were 80.2 mg/dL (95% CI: 70.5 to 90.0) and 100.4 mg/dL (95% CI: 86.7 to 114.2) (P trend = 0.028), and the ratio of total cholesterol to high-density lipoprotein were 3.16 (95% CI: 2.8 to 3.6) and 3.49 (95% CI: 3.0 to 4.0) (P trend =0.006), respectively. The patterns of association were largely consistent across gender, race/ethnicity, and body mass index (normal vs. overweight/obese) subgroups, except in non-Hispanic black and Mexican American, in which the magnitude of the association tended to be smaller. Sensitivity analysis showed that, when intake data from the 1 st 24-hour dietary recall was used, the association remained significant but attenuated substantially. No association was found for total cholesterol and low-density lipoprotein. Conclusions: Overwhelming majority of US adolescents consumed more added sugar than recommended for heart health. Increased intake of added sugar is associated with several measures of dyslipidemia, and reduction of added sugar consumption among adolescents might reduce the risk of developing cardiovascular disease in adults.
Abstract 11329: Superiority of Assessing Endocardial Strain to Whole Wall Thickness Strain by Dobutamine Stress Echocardiography in the Dectection of Coronary Artery Disease
Authors: Jing Ping Sun, Zhiqing Qiao, Yiting Fan, Xuedong Shen, Hang Zhao, Jun Pu, Alex Pui-wai Lee, Ben He, Cheuk-Man Yu
Journal: Circulation (2014)

Background: Myocardial ischemia typically extends from the endocardium to the epicardium. Therefore methods of assessment myocardial functional abnormality at the endocardial layer may permit a more accurate detection of coronary artery disease (CAD) this was testified in the current study with the use of dobutamine stress echocardiography.

Methods: After baseline echocardiographic scans obtained, 40 patients with suspected CAD underwent dobutamine stress echocardiography (peak dose, 40μg/kg/min). Coronary angiography was performed within 3 days after test. Echocardiographic images were post-processed by a layer-specific speckle tracking software (EchoPac Version 113, GE) to measure the peak longitudinal strain (STE-L) at the endocardium, midlayer, and epicardium as well as total wall thickness (STE-W).

Results: Forty patients were enrolled into the study. Among them 22 (mean age of 56 ± 15 years) had significant coronary artery disease (stenosis >70%). This included single-vessel disease at left anterior descending artery (LAD) in 19 patients and triple vessel disease in 3 patients. The other 18 patients had normal coronary angiography. The longitudinal strain at both endocardial layer (-23.6 ± 4.9% vs -31.6 ± 4.9%, p<0.05) and total wall thickness (-18.7 ± 4.4% vs -23.3 ± 4.2%, p-29%, ROC curve area of 0.90, sensitivity of 86 %, specificity of 78%, p -21.8 %, ROC curve area of 0.76, sensitivity of 77%, specificity of 72%, p=0.0004) (Figure).

Conclusion: The use of endocardial layer of longitudinal strain is superior to total wall thickness strain in detecting CAD at the LAD territory.

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Abstract 17193: Porcine Xenograft for Aortic-, Mitral- and Double Valve Replacement. Longterm Results
Authors: Sven Lehmann, Denis Merk, Andreas Oberbach, Christian Etz, Joerg Seeburger, Jens Garbade, Sergey Leontyev, Martin Misfeld, Friedrich W Mohr
Journal: Circulation (2014)

Introduction: Aim of this study was to evaluate the results after stented porcine xenograft implantation (EpicTM, SJM, St.Paul, MN, USA) with Linx™ anticalcification treatment in elderly patients. Methods: A total of 2544 patients receiving aortic (AVR = 1920), mitral (MVR = 347) or double valve (DVR = 277) replacement between 11/2001 and 03/2012 were evaluated. All Patients having elective or emergency indications were included. Outcome was assessed by reviewing the prospectively acquired hospital database results as well as regular follow-up information by annual written interview. Results: Patient age was 76.5±6 (AVR), 73.8±7 (MVR) and 74.2±7 (DVR) years; 54.2% / 41.9% / 42.0% were male, active endocarditis was in 4.5% / 19.9% / 22.1% indication for valve surgery and the logistic EUROSCORE predicted risk for mortality was 15.4±15% / 19.9±19% / 22.3±21%, respectively. Additional surgical procedures were mitral valve repair in 196 (10.2%) (AVR) patients, CABG in 840 [43.8%] (AVR), 82 [23.7] (MVR) and 94 [34.1%] (DVR) patients, cryoablation in 232 [12.1%] / 81 [23.4%] / 67 [24.3%] patients, and surgery on the thoracic aorta in 166 [8.7%] / 12 [3.5%] / 41 [14.9%] patients. Mean aortic cross clamp time was 72.6±28min / 79.9±41min / 125.3±44min. Mean follow-up was 4.2±3.3 years. Freedom from endocarditis after 9 year was 98.3±0.4% / 97.5±1.0% / 97.4±1.6% (p=n.s.). Freedom for valve reoperation was 96.3±0.6% / 93.8±2.4% / 92.8±2.2% (AVR vs. DVR p=0.009). Freedom from neurological event was 95.4±0.9 / 91.5±2.9 / 97.9±1.3. 30 day survival was 89.1±0.07% / 80.4±.2.1% / 77.5±2.5% and 9 year survival was 44.0±1.3% / 33.9±4.7% / 29.5±4.1%, respectively. Conclusions: EpicTM stented porcine xenograft is associated with acceptable survival, freedom from valve related complication and freedom from valve reintervention.
The skin in disseminated intravascular coagulation.
Authors: STANLEY J. ROBBOY, MARTIN C. MIHM, ROBERT W. COLMAN, JOHN D. MINNA
Journal: British Journal of Dermatology (1973)

Journal Article The skin in disseminated intravascular coagulation: PROSPECTIVE ANALYSIS OF THIRTY‐SIX CASES Get access STANLEY J. ROBBOY, STANLEY J. ROBBOY Departments of Pathology, Dermatology and Medicine, Harvard Medical School, and Massachusetts General Hospital, Boston, Department of Pathology, U.S. Ireland Army Hospital, Fort Knox, Kentucky, and the Laboratory of Biochemical Genetics, NHLI, NIH, Bethesda, MD., U.S.A Requests for reprints: Dr Robboy, Department of Pathology, Massachusetts General Hospital, Boston, Massachusetts 02114 U.S.A. Search for other works by this author on: Oxford Academic Google Scholar MARTIN C. MIHM, MARTIN C. MIHM Departments of Pathology, Dermatology and Medicine, Harvard Medical School, and Massachusetts General Hospital, Boston, Department of Pathology, U.S. Ireland Army Hospital, Fort Knox, Kentucky, and the Laboratory of Biochemical Genetics, NHLI, NIH, Bethesda, MD., U.S.A Search for other works by this author on: Oxford Academic Google Scholar ROBERT W. COLMAN, ROBERT W. COLMAN Departments of Pathology, Dermatology and Medicine, Harvard Medical School, and Massachusetts General Hospital, Boston, Department of Pathology, U.S. Ireland Army Hospital, Fort Knox, Kentucky, and the Laboratory of Biochemical Genetics, NHLI, NIH, Bethesda, MD., U.S.A Search for other works by this author on: Oxford Academic Google Scholar JOHN D. MINNA JOHN D. MINNA Departments of Pathology, Dermatology and Medicine, Harvard Medical School, and Massachusetts General Hospital, Boston, Department of Pathology, U.S. Ireland Army Hospital, Fort Knox, Kentucky, and the Laboratory of Biochemical Genetics, NHLI, NIH, Bethesda, MD., U.S.A Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 88, Issue 3, 1 March 1973, Pages 221–229, https://doi.org/10.1111/j.1365-2133.1973.tb07538.x Published: 01 March 1973 Article history Accepted: 29 August 1972 Published: 01 March 1973
Abstract 17603: Integration of an Advanced Heart Failure Pathway in a Rural Community-based Multispecialty Practice
Authors: Bonni Cohen, Joel L Cohen, Eileen M Stuart-Shor
Journal: Circulation (2014)

Introduction:  AHF patients and their families often deal with depression, ↓ social support, and end-of-life decisions. The 2009 HF Guidelines called for supportive care (symptom management, QOL) to be incorporated as a key component in a patient’s plan of care. However, supportive patient-focused evidence-based care is not well integrated into the AHF patient’s usual plan of care, particularly in rural multi-specialty community-based practices (RMCBP) where care is often delivered in silos and access to specialty HF clinics is rare. 1-3   Purpose:  The purpose of this QI/pilot project was to implement an integrated AHF Pathway [stage/classify HF, ↑ patient shared-decision making and symptom management] into a RMCBP.   Methods:  Practice improvement/pilot project. Patients with HF who presented to the RMCBP in southern Georgia were recruited to participate. A template to stage HF was embedded in the EMR for physicians to stage HF as part of the routine visit. Patients who were Class C/D were referred to the NP for bi-weekly HF clinic visits [focused physical/psychosocial assessment, review of meds, HF education, goal-setting]. Recruitment and retention was tracked. Physiologic symptoms and quality of life measures were collected pre and post surveys: MLHFQ and Rand PSQ-18. IRB approval was obtained.   Results:  N=164 HF patients presented to the RMCBP seen by both IM and Cardiology (37% staged) during the 3 month pilot. 15% (n=20) were referred to NP-led AHF clinic; 80% had LVEF    Conclusions:  These data suggest that it is possible to engage physicians in a rural community-based multi-specialty practice to stage and refer AHF patients and that the integration of this care pathway led to improved symptom management and QOL for participants. This has implications for AHF patients who live in rural areas often far from academic teaching centers and specialty HF clinics.
Abstract 18528: Junctional Late Enhancement in Non-ischemic Dilated Cardiomyopathy by Cardiac Magnetic Resonance: A Marker of Ventricular Adaptaton Due to Pulmonary Hypertension
Authors: Martina Perazzolo Marra, Manuel De Lazzari, Annachiara Frigo, Benedetta Giorgi, Giorgio De Conti, Giuseppe Tarantini, Francesco Tona, Cristina Basso, Luisa Cacciaillani, Sabino Iliceto
Journal: Circulation (2014)

Introduction: The potent prognostic impact of pulmonary hypertension (PH) in heart failure (HF) suggests an important role for pre-clinical detection of an ongoing RV remodeling. Several studies have highlighted the presence of late gadolinium enhancement (LGE) in the RV junction of the interventricular septum in the majority of these patients with pre-capillary PH. Hypothesis: to evaluate in non-ischemic dilated cardiomyopathy (NIDC): 1) the prevalence of RV-LV junctional LGE, 2) the relationship between LGE and RV hemodynamics, and 3) its prognostic significance in terms of major events and HF outcome. Methods: a consecutive series of NIDC patients. Exclusion criteria: recent onset of HF, contraindication to CMR. Diagnostic right heart catherization was performed in all. Follow up events: decompensated HF, cardiac death or heart transplantation and ventricular arrhythmias. Results: 118 patients; 38 (32%) showed junctional LGE: in 9/38 LGE was confined only to the junctions points, in 19/38 associated wi...
Distinct roles for p53 transactivation and repression in preventing UCN-01-mediated abrogation of DNA damage-induced arrest at S and G2 cell cycle checkpoints
Authors: Aime A. Levesque, Ethan A. Kohn, Edward Bresnick, Alan Eastman
Journal: Cancer Research (2005)

4424  The topoisomerase I inhibitor SN38 blocks cell cycle progression primarily in S and G2 in a p53-independent manner. The Chk1 inhibitor 7-hydroxystaurosporine (UCN-01) abrogates this arrest preferentially in p53-defective cells, driving them through a lethal mitosis. The precise mechanism by which p53 contributes to the maintenance of S and G2 arrest is not well understood. To investigate the role of p53 in checkpoint regulation, we previously generated the MCF10A/EB cell line by expressing the p53 tetramerization domain in the p53 wildtype MCF10A breast cell line. Both cell lines arrest in S and G2 in response to SN38, p53 accumulates and is phosphorylated on Ser15 and Ser20, but p21waf1 only increases in the MCF10A cells. Upon addition of UCN-01, the MCF10A cells remain arrested in S phase while the MCF10A/EB cells abrogate S but not G2 arrest. The failure to abrogate G2 arrest is attributed to the repression of cyclin B suggesting that the p53 repressor function is retained. To further investigate the impact of p53 on checkpoint regulation, we have now generated MCF10A/Δp53 cells in which p53 is repressed by siRNA. These cells also arrest in S and G2 in response to SN38 treatment, but upon addition of UCN-01, they abrogate both S and G2 arrest. The cells accumulate cyclin B indicating that the p53 repressor function is lost. These results confirm the role of p53 in protecting cells from checkpoint inhibitors. To determine whether the effects seen in the MCF10A/EB cells are due to clonal variation, we generated multiple independent cell lines expressing the p53 tetramerization domain. These cells also arrested in S and G2 in response to SN38 treatment and had attenuated induction of p21. In response to UCN-01, variable responses were observed with some lines abrogating only S phase arrest while others abrogated S and G2 arrest. These differences may be due to varying levels of expression of the transgene. While the consensus sequence for p53-mediated induction contains a repeated element in a head-to-tail orientation, the cyclin B promoter contains a repeated element in a head-to-head orientation. Chk1 is also repressed in a p53-dependent manner, and its promoter contains only a single head-to-head element. These novel elements are unlikely to bind tetramers, but may instead bind dimers. It is possible that low levels of the transfected tetramerization domain may prevent formation of tetramers and thereby inhibit p53-mediated induction, but still permit dimerization and thereby repression of certain genes. High levels of the transgene may also prevent dimerization and thereby overcome p53-mediated repression. This possibility is consistent with the observed results and is currently under further investigation.
Stratum corneum RNA levels are diagnostic for melanoma
Authors: J.M. Grichnik
Journal: British Journal of Dermatology (2011)

Journal Article Stratum corneum RNA levels are diagnostic for melanoma Get access J.M. Grichnik J.M. Grichnik Miller School of Medicine, University of Miami, Miami, FL 33136, U.S.A. E‐mail: grichnik@miami.edu Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 164, Issue 4, 1 April 2011, Pages 693–694, https://doi.org/10.1111/j.1365-2133.2011.10283.x Published: 01 April 2011
Sestamibi Imaging to Triage Patients With Acute Chest Pain
Authors: Neal S. Perlmutter
Journal: JAMA (2003)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal