tbuckley/cabot-search huggingface dataset:
Abstract 9814: Patients with Acute Coronary Syndromes Undergoing Percutaneous Coronary Intervention Have Higher Levels of On-Treatment Platelet Reactivity
Authors: Michael A Gaglia, Rebecca Torguson, Rajbabu Pakala, Gabriel Sardi, Zhenyi Xue, William O Suddath, Kenneth M Kent, Lowell F Satler, Augusto D Pichard, Ron Waksman
Journal: Circulation (2011)

Introduction: High on-treatment platelet reactivity (HOPR) in patients taking clopidogrel is associated with adverse events following PCI. The impact of presentation with an acute coronary syndrome (ACS) upon levels of on-treatment platelet reactivity, however, is not well-understood. Hypothesis: We hypothesized that ACS patients, compared to non-ACS patients, would be more likely to have HOPR as measured by the Vasodilator Stimulated Phosphoprotein Phosphorylation (VASP) assay following PCI. Methods: Patients received 600 mg of clopidogrel and 325 mg aspirin at the time of PCI and underwent platelet reactivity testing with VASP 6-24 hours following PCI. HOPR was defined as a VASP platelet reactivity index &gt;50%. ACS was defined as ≥2 of the following: 1) symptoms consistent with myocardial ischemia; 2) ST-segment elevation or depression ≥1 mm in ≥2 contiguous leads on EKG; 3) cardiac troponin level above the upper limit of normal. VASP platelet reactivity index and HOPR were compared between groups using the Wilcoxon and Chi-square tests, respectively. Multivariable logistic regression was performed to assess the independent effect of ACS upon HOPR. Results: Overall, 377 patients were enrolled; 12.9% presented with ACS, although none presented with cardiogenic shock. Patients with ACS were less likely to have a history of CAD (22.4% v. 59.8%) or previous PCI (12.5% v. 46.6%) and more likely to have a history of congestive heart failure (22.4% v. 11.6%) or a left anterior descending lesion (47.8% v. 30.2%; p &lt;0.001 for all comparisons). Median VASP platelet reactivity index was higher in ACS patients (52.6% v. 38.3%, p=0.02), as was incidence of HOPR (55.1% v. 34.6%, p=0.007). Following multivariable adjustment, ACS remained significantly associated with HOPR (OR 2.18, 95% CI 1.15-4.12, p=0.02; Table). Conclusion: Presentation with ACS is a significant risk factor for HOPR. As such, platelet reactivity testing should focus on such high-risk patients.
Urethral tissue regeneration using collagen scaffold modified with collagen binding VEGF in a beagle model
Authors: Weisheng Jia, He Tang, Jianjian Wu, Xianglin Hou, Bing Chen, Wei Chen, Yannan Zhao, Chunying Shi, Feng Zhou, Wei Yu, Shengquan Huang, Gang Ye, Jianwu Dai
Journal: Biomaterials (2015)
The Role of Clopidogrel in Early and Sustained Arterial Patency After Fibrinolysis for ST-Segment Elevation Myocardial Infarction
Authors: Benjamin M. Scirica, Marc S. Sabatine, David A. Morrow, C. Michael Gibson, Sabina A. Murphy, Stephen D. Wiviott, Robert P. Giugliano, Carolyn H. McCabe, Christopher P. Cannon, Eugene Braunwald
Journal: Journal of the American College of Cardiology (2006)
Abstract 4351: Preoperative Serum Nt-pro Brain Type Natriuretic Peptide Predicts Perioperative Outcome and Midterm Survival Rates of CABG Patients
Authors: Nikolaos Bonaros, Dominik Wiedemann, Johannes Fetz, Guenther Laufer, Alfred Kocher, Johannes Bonatti, Guy Friedrich, Thomas Schachner
Journal: Circulation (2009)

Background: N-terminal fragment of pro brain type natriuretic peptide (BNP) is an established biomarker for cardiac failure. We aimed to determine the influence of preoperative serum BNP on periope...
Abstract 2797: Role of Nitric Oxide in Placental Dysfunction Following Fetal Cardiopulmonary Bypass
Authors: Christopher Lam, R. Scott Baker, Walter C Lubbers, Lawrence C Spezzano, Catie Teuschler, Jerri L McNamara, Robert E Ferguson, Aimee Gardner, John P Lombardi, Kenneth E Clark, Pirooz Eghtesady
Journal: Circulation (2006)

Introduction Placental dysfunction following fetal cardiopulmonary bypass remains the Achilles heel of fetal cardiac surgery. The etiology of the placental dysfunction is unknown. Indirect evidence...
Genetic alteration is a rare event in breast and ovarian carcinoma associated stroma
Authors: Ian Campbell, Wen Qiu, Kylie Gorringe, Ella Thompson, Stephen Fox, Ken Opeskin, Izhak Haviv
Journal: Clinical Cancer Research (2007)

AACR Centennial Conference: Translational Cancer Medicine-- Nov 4-8, 2007; Singapore

B65 

INTRODUCTION: Fibroblasts are a key component of human cancers. Co-culture and xenograft studies have shown that cancer associated fibroblasts (CAFs) play an important role in cancer initiation and progression. The tumour promoting ability of CAFs appears to be stable, suggesting that the cells might be programmed at the genetic or epigenetic level. Some studies have reported a high frequency of genetic aberrations in CAFs including Loss of Heterozygosity (LOH), microsatellite instability and point mutations in tumour suppressor genes and oncogenes, whereas other studies have reported very low or zero mutation rates. Consequently there is no consensus as to whether CAFs do or do not harbour cancer promoting gene mutations. To resolve this important issue, we undertook genome-wide analysis of epithelial and stromal components of 20 primary epithelial ovarian cancers, 10 primary epithelial breast cancers and five short term cultures of primary breast CAFs using the Affymetrix® GeneChip Human mapping 500K array which provides both copy number and LOH data.    METHODS: Epithelial cells and tumour-juxtaposed stromal cells less than 5mm distant from the epithelial component were manually microdissected from fresh frozen ovarian and breast carcinoma biopsies. Cultured CAFs were purified from primay breast cancers using cell-type specific markers. Purified genomic DNA was analyzed using the 500K SNP array and results were compared with the matching normal DNA from blood lymphocytes.    RESULTS: As expected a high frequency of genetic aberration was detected in the epithelial components of each tumour but LOH and copy number alterations were extremely rate in CAFs.    CONCLUSIONS: The 500K SNP array platform has been demonstrated to be a reliable and high resolution genome-analysis platform. Our data does not support the existence of a very high frequency of genetic aberrations in CAF reprted in some studies. It is possible that other mechanisms, such as epigenetic changes, have a role in the tumour promoting phenotypes of CAFs.
Abstract 1370: Overexpression of Mitochondria DNA Helicase, Twinkle, Ameliorates Cardiac Remodeling and Failure in Mice
Authors: Takahiro Inoue, Tomomi Ide, Henna Tyynismaa, Masayoshi Yoshida, Makoto Ando, Atsushi Tanaka, Koji Todaka, Dongchon Kang, Anu Suomalainen, Kenji Sunagawa
Journal: Circulation (2008)
Abstract 8557: Arterial Hypotension Under-Estimates Functional Significance of Stenosis by FFR
Authors: Florence Verdier-Watts, Gilles Rioufol, Ingrid Sanchez, Eric Bonnefoy, Jean-Raymond Caignault, Gerard Finet
Journal: Circulation (2011)

Background It is widely aknowledged that hemodynamics in the cathlab don't influence FFR. Mathematic modelisations suggest however an inverse relationship between arterial pressure and FFR Methods We prospectively studied coronary stenosis with FFR (IC 150 µg adenosin) in patients with mean arterial pressure (Pa) below 85 mmHg. We performed a second measurement after increasing Pa with 0.5 mg neosynephrin IV. The LVEF was normal and the explored-artery free of any history of ACS Results From 2007 to 2010, 14 stenosis (mean stenosis 60±21%) in 12 patients (100% male, 59±11 y) with mean Pa=69 mmHg were studied. After neosynephrin injection Pa increases to 100 mmHg without cardiac frequency variation (65 bpm to 62 bpm). Mean FFR decreases from 0.81±0.11 to 0.75±0.12 (p&lt;0.0001). Five lesions with initial 0.8≤FFR&lt;0.9 dropped below the threshold of 0.80. Conclusions In the clinical setting we confirm that in borderline physiological conditions, FFR is sensitive to perfusion pressure. In case of arterial hypotension during measurement, a non significant FFR &lt;0.90 should be re-tested after normalisation of the arterial pressure.
Abstract 2089: Changes of Diastolic Doppler Indices During Stress Test: Head-to-Head Comparison of Dobutamine Versus Exercise Echocardiography
Authors: Mi-Jeong Kim, Jong Pil Park, Hyo-Jung Nam, Min Kyung Jang, Deck Jin Seo, Jong-Min Song, Duk-Hyun Kang, Jae-Kwan Song
Journal: Circulation (2007)

Background Exercise (EX) and dobutamine stress echocardiogeaphy (DSE) has not been standardized for evaluation of diastolic function. Methods We performed EX and DSE (up to 30 μg/kg/min) in random ...
Abstract 18638: Quantification of Endothelial Activation in Atherosclerosis in vivo With Fluorine Magnetic Resonance Imaging and Spectroscopy
Authors: Hua Pan, Jacob W Myerson, Xiaoxia Yang, Gregory M Lanza, Samuel A Wickline
Journal: Circulation (2010)

Endothelial activation is one of the necessary initial steps in the formation of atherosclerotic plaque that facilitates immune cell recruitment and retention. To image and quantify early markers of endothelial inflammation, we recently developed a multiplexing peptide-based targeting system for post-formulation functionalization of perfluorocarbon nanoparticles that is intrinsically quantifiable at a binding site with 19F magnetic resonance spectroscopy. The approach is now demonstrated in vivo to detect and quantify VCAM-1 in ApoE-/- mouse aorta. Methods and Results: Anti-VCAM-1 targeting peptides were loaded onto PFC nanoparticles (260 nm) after fusion to our amphipathic peptide linker recently developed through modifications to the sequence of melittin, a component of honey bee venom. Specific targeting to VCAM-1 in vitro in mouse endothelial cells subjected to TNF-α stimulation was confirmed by confocal imaging and magnetic resonance imaging (MRI), and quantified by 19F magnetic resonance spectroscop...
Extrapulmonary tuberculosis mimicking Mendelian susceptibility to mycobacterial disease in a patient with signal transducer and activator of transcription 1 (STAT1) gain-of-function mutation
Authors: Shinsuke Kataoka, Hideki Muramatsu, Yusuke Okuno, Yuta Hayashi, Yoko Mizoguchi, Miyuki Tsumura, Satoshi Okada, Masao Kobayashi, Chiaki Sano, Haruki Sato, Ichiro Oh-iwa, Masahumi Ito, Daiei Kojima, Asahito Hama, Yoshiyuki Takahashi, Seiji Kojima
Journal: Journal of Allergy and Clinical Immunology (2015)
Mechanochemistry of cardiac muscle
Authors: C. Lynn Skelton, Peter E. Pool, Shirley C. Seagren, Eugene Braunwald
Journal: Journal of Clinical Investigation (1971)

The possibility that alterations in the rate or efficiency of energy utilization could be involved in the control of cellular oxygen consumption by thyroid hormone was examined in right ventricular papillary muscles isolated from normal euthyroid cats and cats with experimentally induced hyperthyroidism and hypothyroidism. Energy production in the muscles was inhibited and isolated from the process of energy utilization by exposure to iodoacetic acid and nitrogen. After resting or performing variable amounts of contractile element work under isometric conditions, muscles were frozen, and the total amount of chemical energy ( approximately P = creatine phosphate + ATP) used was determined. The resting rate of energy utilization in muscles from euthyroid animals was 0.78+/-0.07 mumoles/g per min of approximately P. This rate was elevated in muscles from hyperthyroid cats to 1.00+/-0.09 mumoles/g per min and decreased in muscles from hypothyroid cats to 0.23+/-0.14 mumoles/g per min. Isometrically contracting muscles from cats with hypothyroidism utilized only 64% as much energy as muscles from euthyroid cats while performing 81% as much contractile element work at a moderately decreased level of contractile state. Muscles from hyperthyroid cats utilized an average of 41% more energy than did muscles from euthyroid cats while contracting an identical number of times and performing an equal amount of contractile element work at a slightly increased level of contractile state. These results suggest that thyroid hormone directly influences the rate of cellular energy utilization. Furthermore, the increase in energy utilization in muscles from hyperthyroid cats could not be attributed entirely to observed alterations in contractile behavior, which indicates that excess thyroid hormone may decrease the efficiency of the conversion of cellular energy to work. However, the opposite effect, an increased efficiency of energy utilization, was not observed in muscles from hypothyroid cats. Thus, it is concluded that the calorigenic effects of thyroid hormone may be explained, at least in part, by alterations in the process of energy utilization.
Prevalence of CAM in a cohort of breast cancer patients and controls
Authors: K. N. Anderson, J. Jacobson, H. Li, D. Hershman, P. Gorroochurn, V. Grann
Journal: Journal of Clinical Oncology (2004)

8131 Background: Estimates of the prevalence of complementary and alternative medicine (CAM) use among breast cancer patients vary widely, and little is known about how CAM treatment among cancer patients may differ from that among cancer-free individuals. We investigated factors associated with CAM use among breast cancer patients at Columbia-Presbyterian and Harlem Hospitals and controls. Methods: Baseline information for a cohort study was collected from black, white, and Hispanic patients recently diagnosed with localized breast cancer (N=294), and their friends and relatives (N=156). The questionnaire asked about recent use of CAM modalities including diet, nutritional supplements, homeopathy, herbal medications, other medications not prescribed by an MD, traditional ethnic medicine, detoxification treatments, water treatment or hydrotherapy, chiropractic, acupuncture, massage or other manual therapy, meditation or prayer, support groups or psychotherapy, healing touch or other energy therapy, or any other form of self help. The questionnaire also asked for socioeconomic and demographic information and health-related behavior, such as mammograms, and pap smears obtained within the last five years, measures of general health, quality of life, and psychosocial distress using the CESD scale and the SF-36. The relationships between these variables and CAM were examined with a logistic regression model in SAS. Results: As the table below indicates, age, income and breast cancer status were significant predictors of CAM; no other variables were significant. Conclusions: Recently diagnosed breast cancer patients were more likely to try CAM than their friends and first-degree relatives. We plan to assess changes in this association during follow-up. No significant financial relationships to disclose.
Abstract P22: An Impedance Threshold Device Combined with an Automated Active Compression Decompression CPR Device (LUCAS) Improves the Chances For Survival in Pigs in Cardiac Arrest
Authors: Timothy R Matsuura, Scott H McKnite, Anja K Metzger, Demetris Yannopoulos, Tom P Aufderheide, Keith G Lurie
Journal: Circulation (2008)

Background: By lowering intrathoracic pressure during the chest recoil phase of CPR, the impedance threshold device (ITD) increases circulation and the rate of return of spontaneous circulation (ROSC). This study evaluated the ITD combined with a new automated CPR device, the US version of the LUCAS, that compresses the chest and then pulls upwards with a 3 lb force. Methods and Results: After 6 min of untreated ventricular fibrillation, anesthetized female pigs (40.0±0.7 kg) were randomized to 6 min of CPR (100 compressions/min with LUCAS and ventilation: 1.0 FiO2, tidal volume of 10ml/kg, rate 12/min) with an active (−10 cm H2O resistance) (n=12) or sham ITD (n=12), and then shocked once with 120 joules of direct current. Epinephrine (0.04 mg/kg) and more CPR and shocks were used if ROSC was not achieved. Results (in mmHg) after 6 min of CPR with an active vs. sham ITD were: coronary perfusion pressure (PP) 20.8±1.2 vs. 21.0±0.9 (p=0.94); cerebral PP 8.8±1.0 vs. 10.0±0.9 (p=0.62); and end tidal CO2 38.1±1.5 and 37.1±1.3 (p=0.61). Peak and mean carotid artery blood flow (ml/min) was 323.9±15.2 vs. 256.6±21.1 (p=0.17) and 95.3±5.4 vs. 77.0±6.0 (p=0.22) with an active vs. sham ITD, respectively. Mean endotracheal pressures (mmHg) during chest recoil with an active vs. sham ITD were −2.0±0.5 vs. −0.2±0.2 (p&lt;0.01). Arterial and venous blood gases were similar after 6 min of CPR between groups. ROSC, the primary survival endpoint for comparing the active vs. sham ITD, was 7/12 vs. 2/12 after 1 shock (p= 0.09), 12/12 vs. 5/12 after 2 shocks (p&lt;0.01), and 12/12 vs. 7/12 after 3 shocks (p=0.04). With up to 14 shocks, 10/12 sham animals had a ROSC. All animals with ROSC lived for 30 min. There was no evidence of pulmonary edema or organ damage on autopsy with either ITD. Conclusions: After 6 min of CPR, LUCAS and active ITD resulted in lower mean airway pressures during chest recoil versus controls but hemodynamic findings were similar. However, ROSC was significantly easier to achieve with an active ITD; with up to 3 shocks twice as many animals were resuscitated with an active ITD. This benefit is most likely explained by carotid blood flows that trended higher with the active ITD. These positive findings and lack of any adverse outcomes support the safety and efficacy of this device combination.
High-Risk Plaque Detected on Coronary CT Angiography Predicts Acute Coronary Syndromes Independent of Significant Stenosis in Acute Chest Pain
Authors: Stefan B. Puchner, Ting Liu, Thomas Mayrhofer, Quynh A. Truong, Hang Lee, Jerome L. Fleg, John T. Nagurney, James E. Udelson, Udo Hoffmann, Maros Ferencik
Journal: Journal of the American College of Cardiology (2014)
Abstract 16411: Gonadectomized XX Mice are More Prone to Ischemia/Reperfusion Injury Than XY Mice, Irrespective of Gonadal Sex
Authors: Jingyuan Li, Rebecca Watkins, Xuqi Chen, Arthur P Arnold, Mansoureh Eghbali
Journal: Circulation (2011)

Introduction Sex differences in susceptibility to ischemia/reperfusion (I/R) injury have been demonstrated both in basic and clinical settings. Female hearts show better functional recovery after I...
American College of Cardiology 2006 Principles to Guide Physician Pay-for-Performance Programs
Authors: John E. Brush, Harlan M. Krumholz, Janet S. Wright, Ralph G. Brindis, Joseph G. Cacchione, Joseph P. Drozda, James W. Fasules, Kathleen B. Flood, Arthur Garson, Frederick A. Masoudi, Tilithia McBride, Charles R. McKay, Joseph V. Messer, Michael J. Mirro, Michael F. O’Toole, Eric D. Peterson, John W. Schaeffer, C. Michael Valentine
Journal: Journal of the American College of Cardiology (2006)
Catheter Ablation for Atrial Fibrillation
Authors: Rukshen Weerasooriya, Paul Khairy, Jean Litalien, Laurent Macle, Meleze Hocini, Frederic Sacher, Nicolas Lellouche, Sebastien Knecht, Matthew Wright, Isabelle Nault, Shinsuke Miyazaki, Christophe Scavee, Jacques Clementy, Michel Haissaguerre, Pierre Jais
Journal: Journal of the American College of Cardiology (2011)
Abstract 18073: Traditional Lipid and Advanced Lipoprotein Associations With Subclinical Atherosclerosis of Persons Living With and Without HIV: The Multicenter AIDS Cohort Study (MACS)
Authors: Michelle Zikusoka, Jennifer Deal, Lisa P Jacobson, Frank J Palella, Matthew Budoff, Mallory D Witt, Lawrence A Kingsley, Todd Brown, Wendy S Post
Journal: Circulation (2013)

Background: HIV infection is associated with coronary artery disease (CAD). We previously observed that HIV-infected (HIV+) men had a higher prevalence of non-calcified plaque than uninfected (HIV-) men. We tested associations between lipids and plaque composition and differences by HIV status. Methods: We performed non-contrast (n=613) and contrast coronary (n= 464) CT scans to measure coronary calcium (CAC), total plaque (TP), non-calcified plaque (NCP), calcified plaque (CP), mixed plaque (MP) and stenosis greater than 50%. Traditional lipid and advanced lipoprotein measures with nuclear magnetic resonance (NMR) were determined using blood samples in HIV+ and HIV- men who have sex with men (MSM) age 40-70 years. Separate logistic regression models were used to estimate associations between presence of plaque and each lipid variable, adjusting for age, race, CAD risk factors, and use of cholesterol medications. Effect modification by HIV was tested with interaction terms. Results: HIV+ men had lower LDL particle concentrations (LDL-p), but higher small LDL-p and smaller LDL-p size. HIV+ men had higher medium HDL-p and lower total, large and small HDL-p and traditional HDL concentrations. They had higher total and large VLDL-chylomicron (CHY), medium VLDL, VLDL particle size, NMR VLDL-CHY-TG concentrations and higher traditional TG (p&lt;0.05). Increased LDL-p and small LDL-p were both associated with the presence of CAC, any plaque (TP), NCP, CP, and MP (all p&lt; 0.03; OR per SD 1.27- 1.41). Large HDL-p and HDL were inversely associated with presence of TP, NCP and MP (all p&lt;0.05; OR per SD 0.67-0.79). Increased VLDL-CHY, small VLDL-p, small LDL-p and traditional TG were associated with stenosis greater than 50% (all p&lt;0.02; OR per SD 1.49-1.57). Cholesterol medication use was positively associated with presence of CAC, TPS, MP, and CP, but not NCP. There were no significant interactions by HIV status for these outcomes. Conclusions: Most plaque subtypes are associated with LDL and HDL particles. Cholesterol medication use is associated with calcified plaque but not NCP. VLDL and TG particles were associated with stenosis &gt; 50%. HIV+ men have higher concentrations of atherogenic lipid particles than HIV- men, which may explain some of the increased risk for CAD.
Prediction and validation of hemodialysis duration in acute methanol poisoning
Authors: Philippe Lachance, Fabrice Mac-Way, Simon Desmeules, Sacha A. De Serres, Anne-Sophie Julien, Pierre Douville, Marc Ghannoum, Mohsen Agharazii
Journal: Kidney International (2015)

The duration of hemodialysis (HD) in methanol poisoning (MP) is dependent on the methanol concentration, the operational parameters used during HD, and the presence and severity of metabolic acidosis. However, methanol assays are not easily available, potentially leading to undue extension or premature termination of treatment. Here we provide a prediction model for the duration of high-efficiency HD in MP. In a retrospective cohort study, we identified 71 episodes of MP in 55 individuals who were treated with alcohol dehydrogenase inhibition and HD. Four patients had residual visual abnormality at discharge and only one patient died. In 46 unique episodes of MP with high-efficiency HD the mean methanol elimination half-life (T1/2) during HD was 108 min in women, significantly different from the 129 min in men. In a training set of 28 patients with MP, using the 90th percentile of gender-specific elimination T1/2 (147 min in men and 141 min in women) and a target methanol concentration of 4 mmol/l allowed all cases to reach a safe methanol of under 6 mmol/l. The prediction model was confirmed in a validation set of 18 patients with MP. High-efficiency HD time in hours can be estimated using 3.390 × (Ln (MCi/4)) for women and 3.534 × (Ln (MCi/4)) for men, where MCi is the initial methanol concentration in mmol/l, provided that metabolic acidosis is corrected.