Norfloxacin: A New Drug in the Treatment of Falciparum Malaria
Authors: P. S. Sarma
Journal: Annals of Internal Medicine (1989)

Brief Reports15 August 1989Norfloxacin: A New Drug in the Treatment of Falciparum MalariaP. S. Sarma, MDP. S. Sarma, MDAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-111-4-336 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptNorfloxacin is a potent antibacterial agent that inhibits the action of topoisomerase II (1, 2). The chance discovery of simultaneous eradication of Plasmodium falciparum and Pseudomonas aeruginosa by norfloxacin prompted the author to report the results of treating uncomplicated falciparum malaria with norfloxacin.Patients and MethodsNine adult patients hospitalized for falciparum malaria were studied. The patient group consisted of seven men and two women; the mean age was 28.1 years. Asexual forms ofP. falciparumwere seen on peripheral blood smears. The number of parasites per 200 leukocytes was calculated on Leishman-stained thick blood film. Patients who were severely...References1. Epstein R. Topoisomerases in human disease. Lancet. 1988;1:521-4. CrossrefMedlineGoogle Scholar2. Neu H. Clinical use of the quinolones. Lancet. 1987;2:1319-22. CrossrefMedlineGoogle Scholar3. DivoGaeryJensen ATJ. Oxygen- and tissue-dependent effects of antibiotics and selected mitochondrial inhibitors on Plasmodium falciparum in culture. Antimicrob Agents Chemother. 1985;27:21-7. CrossrefMedlineGoogle Scholar4. MidgleyKaterPhillipsonGrantWarhurst JDJSD. Quinolones and multiresistant Plasmodium falciparum [Letter]. Lancet. 1988;2:281. CrossrefMedlineGoogle Scholar5. KrishnaDaviesChanWellsRobson STPRK. Ciprofloxacin and malaria [Letter]. Lancet. 1988;1:1231-2. CrossrefMedlineGoogle Scholar6. RiouGabillotPhilippeSchrevelRiou JMMJG. Purification and characterization of Plasmodium berghei DNA topoisomerases I and II: drug action, inhibition of decatenation and relaxation, and stimulation of DNA cleavage. Biochemistry. 1986;25:1471-9. CrossrefMedlineGoogle Scholar7. WolfsonHooper JD. The fluoroquinolones: structures, mechanisms of action and resistance, and spectra of activity in vitro. Antimicrob Agents Chemother. 1985;28:581-6. CrossrefMedlineGoogle Scholar8. JiangLiGuoKongArnold JGXYK. Antimalarial activity of mefloquine and qinghaosu. Lancet. 1982;2:285-8. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: From the Jawaharlal Nehru Hospital and Research Centre, Bhilainagar, India. For current author address, see end of text. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byIn vitro synergistic effect of fluoroquinolone analogues in combination with artemisinin against Plasmodium falciparum; their antiplasmodial action in rodent malaria modelTargeting the gyrase of Plasmodium falciparum with topoisomerase poisonsAmodiaquine–Ciprofloxacin: a potential combination therapy against drug resistant malariaAntiviral, antifungal, and antiparasitic activities of fluoroquinolones optimized for treatment of bacterial infections: a puzzling paradox or a logical consequence of their mode of action?Microbial transformations of antimicrobial quinolones and related drugsOxygenated chalcones and bischalcones as a new class of inhibitors of DNA topoisomerase II of malarial parasitesAntimicrosporidial activity of (fluoro)quinolones in vitro and in vivoIn vitro antimalarial activity of trovafloxacin, a fourth-generation fluoroquinoloneDNA topoisomerases: a new twist for antiparasitic chemotherapy?History and IntroductionInefficacy of Quinolones in MalariaSection Review Anti-infectives: The future role of quinolonesAntibiotiques et paludisme. Revue de la littératureNorfloxacin is not effective for treatment of Plasmodium falciparum infection in KenyaUsefulness of clinical case-definitions in guiding therapy for African children with malaria or pneumoniaCiprofloxacin does not achieve radical cure of Plasmodium falciparum infection in Sierra LeonePefloxacin for Falciparum Malaria: Only Modest SuccessPhilippe Deloron, MDPhD, Jean Paul Lepers, MD, Lucie Raharimalala, MD, Béatrice Dubois, MA, Pierre Coulanges, MD, Jean Jacques Pocidalo, PhDNewly documented antimicrobial activity of quinolonesNorfloxacin, the first of a new class of fluoroquinolone antimicrobials, revisitedRecent Developments in the Field of Quinolone Antibacterial AgentsActivities of pefloxacin and ciprofloxacin against experimental malaria in miceChapter 12. Antibacterial AgentsFluoroquinolones for Malaria: The Newest Kid on the Block?David J. Wyler, MD 15 August 1989Volume 111, Issue 4Page: 336-337KeywordsAntibioticsBloodDrugsMalariaMedical servicesPlasmodium falciparumPseudomonas aeruginosaResearch laboratories Issue Published: 15 August 1989 PDF downloadLoading ...