MEGALOBLASTIC ANEMIA DUE TO DILANTIN THERAPY
Authors: A LUSTBERG, D GOLDMAN, O H DRESKIN
Journal: Annals of Internal Medicine (1961)

Case Reports1 January 1961MEGALOBLASTIC ANEMIA DUE TO DILANTIN THERAPYALFRED LUSTBERG, M.D., DOUGLAS GOLDMAN, M.D., O. HERMAN DRESKIN, M.D.ALFRED LUSTBERG, M.D.Search for more papers by this author, DOUGLAS GOLDMAN, M.D.Search for more papers by this author, O. HERMAN DRESKIN, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-54-1-153 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe occurrence of megaloblastic anemia following the use of anticonvulsant drugs has been reported in the British and Scandinavian literature. We believe the following case is among the first in the American literature.CASE REPORTSince age 19, a 42-year-old white female had been admitted intermittently to state hospitals for treatment of a convulsive disorder, at times associated with psychotic manifestations. From December, 1951, to November 6, 1958, treatment had consisted of Dilantin, gr. 1½, three times a day, and phenobarbital, gr. ½, three times a day. This was reduced to twice a day from November 6, 1958, until December...Bibliography1. Badenoch J: Use of labelled vitamin B12 and gastric biopsy in the investigation of anemia. Proc. Roy. Soc. Med. 47: 426-427 (June) 1954. MedlineGoogle Scholar2. HawkinsMeynell CFMJ: Megaloblastic anemia due to phenytoin sodium. Lancet 2: 737 (Oct. 9) 1954. CrossrefGoogle Scholar3. ChalmersBoheimer JNK: Megaloblastic anemia and anticonvulsant therapy. Lancet 2: 920, 1954. CrossrefGoogle Scholar4. Fuld H: Megaloblastic anemia following anticonvulsants. Brit. Med. J. 1: 1475, 1955. CrossrefGoogle Scholar5. NewmanSummer MJDW: Megaloblastic anemia following use of primidone. Blood 12: 183, 1957. CrossrefMedlineGoogle Scholar6. ChanarinElmerMollin IPCDL: Folic acid studies in megaloblastic anemia due to primidone. Brit. M. J. 2: 80-82, 1958. CrossrefMedlineGoogle Scholar7. CalvertHurworthBean RJEAL: Megaloblastic anemia from methophenobarbital. Blood 13: 894, 1958. CrossrefMedlineGoogle Scholar8. ChristensonUltmannRoseman WWJEDM: Megaloblastic anemia during primidone (Mysoline) therapy. J. A. M. A. 163: 940 (Mar. 16) 1957. CrossrefMedlineGoogle Scholar9. HawkinsMeynell CFMJ: Macrocytosis and macrocytic anemia caused by anticonvulsant drugs. Quart. J. Med. 27: 45-64, 1958. MedlineGoogle Scholar10. RhendVaradi EGS: Megaloblastic anemia due to phenytoin. Lancet 2: 920-921, 1954. Google Scholar11. BerlgneMcCloshan LMA: Megaloblastic anemia following anticonvulsants. Brit. Med. J. 1: 1247, 1957. CrossrefGoogle Scholar12. Girdwood RH: The megaloblastic anemias. Quart. J. Med. 25: 87-119, 1956. MedlineGoogle Scholar13. KeddMollin PDL: Megaloblastic anemia and vitamin B12 deficiency after anticonvulsant therapy. Brit. Med. J. 2: 974-976 (Oct. 26) 1957. CrossrefMedlineGoogle Scholar14. BeniansHunter RCRA: Megaloblastic anemia occurring during treatment of epilepsy with sodium phenytoin, primidone and phenobarbitone. J. Ment. Sci. 103: 606, 1957. CrossrefMedlineGoogle Scholar15. RyanForshaw GMJW: Megaloblastic anemia due to sodium phenytoin. Brit. Med. J. 2: 242, 1955. CrossrefMedlineGoogle Scholar16. Gydell K: Megaloblastic anemia in patients treated with diphenylhydantoin and primidone. Acta haemat. 17: 1, 1957. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Cincinnati, Ohio*Received for publication August 28, 1959.From the Medical Services of Longview State Hospital, Cincinnati, Ohio.Requests for reprints should be addressed to Alfred Lustberg, M.D., 511 Doctors Building, 19 Garfield Place, Cincinnati 2, Ohio. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byUse of Therapeutic Drug Monitoring, Electronic Health Record Data, and Pharmacokinetic Modeling to Determine the Therapeutic Index of Phenytoin and LamotrigineGingival EnlargementGingival hyperplasia and folic acid deficiency from anticonvulsive drug therapy A theoretical relationshipMyeloidOral Changes in a Folic Acid Deficient Patient Precipitated by Anticonvulsant Drug TherapyDie megaloblastischen AnämienHaematological Aspects during Treatment with Anticonvulsant DrugsDiphenylhydantoin-induced hypersensitivity reactionDiagnostically Confusing Complications of Diphenylhydantoin Therapy A ReviewMARSHALL SPARBERG, M.D.Anticonvulsant-Associated Megaloblastic Anemia 1 January 1961Volume 54, Issue 1Page: 153-158KeywordsAnticonvulsantsFolic acidMedical servicesMegaloblastic anemia ePublished: 1 December 2008 Issue Published: 1 January 1961 PDF downloadLoading ...