Pregnancy in Women With Systemic Lupus Erythematosus: Messages for the Clinician
Authors: Bevra H. Hahn
Journal: Annals of Internal Medicine (2015)

Editorials4 August 2015Pregnancy in Women With Systemic Lupus Erythematosus: Messages for the ClinicianBevra H. Hahn, MDBevra H. Hahn, MDFrom David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, California.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/M15-1301 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail In this issue, Buyon and colleagues (1) report findings from the PROMISSE (Predictors of Pregnancy Outcome: Biomarkers in Antiphospholipid Antibody Syndrome and Systemic Lupus Erythematosus) study, a large prospective study of pregnancy outcomes in women with systemic lupus erythematosus (SLE). The study involved 8 centers in the United States and 1 in Canada serving patients of diverse socioeconomic status and ethnicity. The restrictions for study entry are important to note. Patients were required to have reached at least 12 weeks of a singleton gestation; have inactive SLE or mild to moderate SLE activity; be free of heavy proteinuria, microscopic hematuria, ...References1. Buyon JP, Kim MY, Guerra MM, Laskin CA, Petri M, Lockshin MD, et al. Predictors of pregnancy outcomes in patients with lupus. A cohort study. Ann Intern Med. 2015;163:153-63. [PMID: 26098843] doi:10.7326/M14-2235 LinkGoogle Scholar2. Clark CA, Spitzer KA, Laskin CA. Decrease in pregnancy loss rates in patients with systemic lupus erythematosus over a 40-year period. J Rheumatol. 2005;32:1709-12. [PMID: 16142865] MedlineGoogle Scholar3. Georgiou PE, Politi EN, Katsimbri P, Sakka V, Drosos AA. Outcome of lupus pregnancy: a controlled study. Rheumatology (Oxford). 2000;39:1014-9. [PMID: 10986308] CrossrefMedlineGoogle Scholar4. Clowse MEB. Pregnancy in women with SLE.. In: Wallace DJ, Hahn BH, eds. Dubois' Lupus Erythematosus and Related Syndromes, 8th ed. Philadelphia: Elsevier, Saunders; 2013:455-63. Google Scholar5. Clowse ME, Magder LS, Witter F, Petri M. The impact of increased lupus activity on obstetric outcomes. Arthritis Rheum. 2005;52:514-21. [PMID: 15692988] CrossrefMedlineGoogle Scholar6. Østensen M, Khamashta M, Lockshin M, Parke A, Brucato A, Carp H, et al. Anti-inflammatory and immunosuppressive drugs and reproduction. Arthritis Res Ther. 2006;8:209. [PMID: 16712713] CrossrefMedlineGoogle Scholar7. de Jesus GR, Agmon-Levin N, Andrade CA, Andreoli L, Chighizola CB, Porter TF, et al. 14th International Congress on Antiphospholipid Antibodies Task Force report on obstetric antiphospholipid syndrome. Autoimmun Rev. 2014;13:795-813. [PMID: 24650941] doi:10.1016/j.autrev.2014.02.003 CrossrefMedlineGoogle Scholar8. Empson M, Lassere M, Craig JC, Scott JR. Recurrent pregnancy loss with antiphospholipid antibody: a systematic review of therapeutic trials. Obstet Gynecol. 2002;99:135-44. [PMID: 11777524] MedlineGoogle Scholar Author, Article, and Disclosure InformationAffiliations: From David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, California.Disclosures: Disclosures can be viewed at www.acponline.org/authors/icmje/ConflictOfInterestForms.do?msNum=M15-1301.Corresponding Author: Bevra H. Hahn, MD, Distinguished Professor of Medicine (Emeritus), Division of Rheumatology, David Geffen School of Medicine, University of California, Los Angeles, Room 31-75, 1000 Veteran Avenue, Los Angeles, CA 90095.This article was published online first at www.annals.org on 23 June 2015. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoPredictors of Pregnancy Outcomes in Patients With Lupus Jill P. Buyon , Mimi Y. Kim , Marta M. Guerra , Carl A. Laskin , Michelle Petri , Michael D. Lockshin , Lisa Sammaritano , D. Ware Branch , T. Flint Porter , Allen Sawitzke , Joan T. Merrill , Mary D. Stephenson , Elisabeth Cohn , Lamya Garabet , and Jane E. Salmon Predictors of Pregnancy Outcomes in Patients With Lupus Jill P. Buyon , Mimi Y. Kim , Marta M. Guerra , Carl A. Laskin , Michelle Petri , Michael D. Lockshin , Lisa Sammaritano , D. Ware Branch , T. Flint Porter , Allen Sawitzke , Joan T. Merrill , Mary D. Stephenson , Elisabeth Cohn , Lamya Garabet , and Jane E. Salmon Metrics Cited ByIntestinal macrophages in mucosal immunity and their role in systemic lupus erythematosus disease 4 August 2015Volume 163, Issue 3Page: 232-233KeywordsAntibodiesAnticoagulantsGlucocorticoid therapyHeparinHypertensionLupus erythematosusPregnancyProspective studiesProteinuria ePublished: 4 August 2015 Issue Published: 4 August 2015 CopyrightCopyright © 2015 by American College of Physicians. All Rights Reserved.PDF DownloadLoading ...