Vitamin D Economy in Gastrointestinal Disease
Authors: JOHN G. HADDAD
Journal: Annals of Internal Medicine (1977)

Editorial Notes1 November 1977Vitamin D Economy in Gastrointestinal DiseaseJOHN G. HADDAD JR., M.D.JOHN G. HADDAD JR., M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-87-5-629 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTwo sources provide vitamin D to man: photoconversion of 7-dehydrocholesterol to cholecalciferol (vitamin D3) during skin exposure to effective ultraviolet light, and intestinal absorption of dietary vitamin D. In addition to the absorption of dietary vitamin D, the small intestine is the site for absorption of vitamin D and metabolites which enter the intestine via the bile. The vitamin and its metabolites are transported in blood via a specific binding protein that uniquely has both high-affinity and high-capacity characteristics. Vitamin D is transformed in the liver to 25-hydroxyvitamin D (25-OHD), which then undergoes 1-hydroxylation to form 1,25-dihydroxyvitamin D (1,25-(OH)2D) in...References1. ROSENSTREICHRICHVOLWILER SCW: Deposition in and release of vitamin D3 from body fat: evidence for a storage site in the rat. J Clin Invest 50:679-687, 1971 CrossrefMedlineGoogle Scholar2. MAWERBACKHOUSEHOLMANLUMBSTANBURY EJCGS: The distribution and storage of vitamin D and its metabolites in human tissues. Clin Sci 43:413-431, 1972 CrossrefMedlineGoogle Scholar3. DELUCASCHNOES HH: Metabolism and mechanism of action of vitamin D. Ann Rev Biochem 45:631-666, 1976 CrossrefMedlineGoogle Scholar4. AVIOLILEEMCDONALDLUNDDELUCA LSJJH: Metabolism of vitamin D3-3H in human subjects: distribution in blood, bile, feces and urine. J Clin Invest 46:983-992, 1967 CrossrefMedlineGoogle Scholar5. ARNAUDGOLDSMITHLAMBERTGO SRPV: 25-Hydroxyvitamin D3: evidence of an enterohepatic circulation in man. Proc Soc Exp Biol Med 149:570-572, 1975 CrossrefMedlineGoogle Scholar6. SKINNERLONGSHERLOCKWILLS RRSM: 25-hydroxylation of vitamin D in primary biliary cirrhosis. Lancet 1:720-721, 1977 CrossrefMedlineGoogle Scholar7. HAUSSLERBAYLINKHUGHESBRUMBAUGHWERGEDALSHENNIELSENCOUNTSBURSACMCCAIN MDMPJFRSKT: The assay of 1α, 25-dihydroxyvitamin D3: physiologic and pathologic modulation of circulating hormone levels. Clin Endocrinol 5:151s-165s, 1976 CrossrefMedlineGoogle Scholar8. EDDY R: Metabolic bone disease after gastrectomy. Am J Med 50:442-449, 1971 CrossrefMedlineGoogle Scholar9. GERTNERLILBURNDOMENECH JMM: 25-hydroxycholecalciferol absorption in steatorrhea and post-gastrectomy osteomalacia. Br Med J 1:1310-1312, 1977 CrossrefMedlineGoogle Scholar10. THOMPSONLEWISBOOTH GBC: Vitamin D absorption after partial gastrectomy. Lancet 1:457-458, 1966 CrossrefMedlineGoogle Scholar11. THOMPSONLEWISBOOTH GBC: Absorption of vitamin D3-3H in control subjects and patients with intestinal malabsorption. J Clin Invest 45:94-102, 1966 CrossrefMedlineGoogle Scholar12. STAMP T: Intestinal absorption of 25-hydroxycholecalciferol. Lancet 2:121-123, 1974 CrossrefMedlineGoogle Scholar13. THOMPSONTHOMPSON WG: Effect of cholestyramine on the absorption of vitamin D3 and calcium. Gut 10:717-722, 1969 CrossrefMedlineGoogle Scholar14. TEITELBAUMHALVERSONBATESWISEHADDAD SJMLJ: Abnormalities of circulating 25-OH vitamin D after jejunal-ileal bypass for obesity. Ann Intern Med 86:289-293, 1977 LinkGoogle Scholar15. COMPSTONCREAMER JB: Plasma levels and intestinal absorption of 25-hydroxyvitamin D in patients with small bowel resection. Gut 18:171-175, 1977 CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: JOHN G. HADDADJR., M.D.Affiliations: Department of Medicine The Jewish Hospital of St. Louis St. Louis, Missouri PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited by6 OsteomalaciaProgressive tubulointerstitial renal disease in infancy with associated hepatic abnormalitiesFacts about Vitamins and Minerals 1 November 1977Volume 87, Issue 5Page: 629-630KeywordsBileBloodLiverMetabolitesProteinsSmall intestineVitamin D ePublished: 1 December 2008 Issue Published: 1 November 1977 PDF downloadLoading ...