tbuckley/cabot-search huggingface dataset:
Decrease in Diversity of Nasal Microbiota during Wheezing Episodes in Preschool Children
Authors: Gorka Alkorta-Aranburu, Catherine Igartua, Emily R. Davenport, Katherine Naughton, So Watanabe, Yoav Gilad, Robert F. Lemanske, David M. Mauger, Carole Ober, Daniel J. Jackson, Jayant M. Pinto
Journal: Journal of Allergy and Clinical Immunology (2015)
Activation of the T-Cell Oncogene<i>LMO2</i>after Gene Therapy for X-Linked Severe Combined Immunodeficiency
Authors: Matthew P. McCormack, Terence H. Rabbitts
Journal: New England Journal of Medicine (2004)

Gene therapy, in which a retrovirus was used to carry the relevant gene (IL2Rγc) into a patient's hematopoietic stem cells, was used to treat 10 boys with X-linked severe combined immunodeficiency (SCID). A syndrome resembling T-cell leukemia developed in two of the boys. In both boys — and a third in whom leukemia has not developed — the retrovirus integrated into the same genomic site, the locus of LMO2, which is involved in childhood lymphocytic leukemia. This article reviews the molecular biology of these events and discusses their implications for the future of gene therapy.
Suicide among Falkland war veterans
Authors: J. Holmes, N. T. Fear, K. Harrison, J. Sharpley, S. Wessely
Journal: BMJ (2013)

Responses should be based on sound statistics not misleading sound bites

The media sound bite, “more Falklands veterans have taken their own life than were killed in the war” has been in common use for about a decade. A recent report from the Ministry of Defence Defence Statistics (Health) has shown it to be incorrect—95 suicides have been recorded among Falklands veterans, whereas 237 deaths among UK Armed Forces personnel occurred during the campaign.1 The report also found no overall increase in the suicide rate of Falklands veterans compared with the general population of the United Kingdom. So where did this false statistic come from, and why was it so misleading?

The claim that more Falklands war veterans have committed suicide than were killed in action was first made in 2002, the 20th anniversary of the war. A report in the Mail on Sunday gave a figure of 264 suicides compared with the accepted figure of 237 UK military personnel killed in action (plus 18 deaths among coalition forces).2 The source was reported as the South Atlantic Medal Association, the principal group for UK Falkland veterans, although the association denied this. Only six months earlier the Guardian had reported a figure of around 100 suicides among Falkland veterans.3

However, the sound bite became ubiquitous, with the figure of 264 suicides appearing consistently over …
IMMUNIZATION AGAINST THE ACTION OF SUBSTANCES INHIBITING TUMOR GROWTH
Authors: Moyer S. Fleisher, Miguel Vera, Leo Loeb
Journal: The Journal of Experimental Medicine (1914)

1. Through a set of preliminary injections of colloidal copper or hirudin, given from the second to the sixth day after transplantation, we can weaken the effect of injections of the same substances given from the ninth to the thirteenth day after transplantation. 2. Injections of colloidal copper given before the transplantation of the tumor lead to a weakening of the effect of injections given from the ninth to the thirteenth day after transplantation. 3. The same result can be obtained if we inject colloidal copper or hirudin into mice from the second to the sixth and from the ninth to the thirteenth day after transplantation, and use these tumors at the end of the series of injections for further transplantation into another set of mice; the developing tumors are more resistant to the action of colloidal copper or hirudin than new control tumors. 4. We may therefore conclude that the immunity has two sources: (a) it is based on changes taking place somewhere in the host organism; and (b) it is localized in the tumor cells themselves which transfer this immunity to the following generations of tumor cells. 5. The immunity acquired against colloidal copper does not protect noticeably against the action of hirudin, and vice versa. The immunity is therefore specific. 6. We discuss certain general conclusions which may be drawn from these experiments. We expect to test the validity of these results in further experiments.
Anti-inflammatory effect of the conjugate of superoxide dismutase with the copolymer of divinyl ether and maleic anhydride against rat re-expansion pulmonary edema
Authors: Takashi Hirano, Takeshi Todoroki, Riichiro Morita, Shuji Kato, Yuko Ito, Ki-Ho Kim, Parshuram Gajanan Shukla, Francesco Veronese, Hiroshi Maeda, Shinichi Ohashi
Journal: Journal of Controlled Release (1997)
Abstract 2947: Knockdown of splicing factor SRp20 induces apoptosis in ovarian tumor cells
Authors: Xiaolong He, Ahmet D. Arslan, Tsui-Ting Ho, William T. Beck
Journal: Cancer Research (2010)

Abstract SRp20 is a member of the serine/arginine-rich (SR) protein family with multiple functions in RNA processing such as alternative splicing and polyadnylation. Our previous studies found that SRp20, together with another splicing factor, polypyrimidine tract-binding protein (PTB), is up-regulated in human ovarian tumors compared to normal ovarian surface epithelia (He, X et al, Clin Cancer Res, 10:4652). In order to determine whether overexpressed SRp20 is required for ovarian tumor cell growth, we studied the effects of SRp20 knockdown in several ovarian cancer cell lines. The knockdown of SRp20 expression was achieved by lentivirus-delivered, doxycycline (Dox)-induced siRNAs. We identified two effective siRNAs against SRp20, SRp20si1 and SRp20si2, which can suppress SRp20 expression by approximately 50% and 90%, respectively. In ovarian cancer cell lines A2780, SKOV3 and IGROV1, knockdown of SRp20 by either SRp20 siRNA caused substantial inhibition of cell growth and colony formation in soft agar. The degree of inhibition correlated with the extent of SRp20 suppression. Massive down-regulation of SRp20 expression by SRp20si2 led to almost complete loss of A2780's capability to form colonies in soft agar. Moreover, Hoechst 33342 staining revealed that the percentage of apoptotic cells was remarkably increased when SRp20 was knocked down ∼90% by SRp20si2. In contrast, moderate suppression (∼50%) of SRp20 by SRp20si1 did not trigger apoptosis. These results suggest that overexpression of SRp20 is required for ovarian cancer cell growth and survival. To determine which apoptotic pathway is activated by SRp20 knockdown, we examined the cleaved fragments of several caspases by immunoblotting and found that caspases 9, 3 and 7 but not caspases 2 and 8were cleaved in cells with SRp20 knocked down by SRp20si2. These results imply that the intrinsic apoptotic pathway is activated by massive SRp20 knockdown. In support of this, we also observed a substantial down-regulation of Bcl-2, a major anti-apoptotic regulator of the intrinsic apoptotic pathway, in the above cells. How SRp20 regulates Bcl-2 expression is unclear at present and currently under investigation. (Supported in part by CA40570 and CA138762 from NCI (to WTB), in part by OCRF (to XH), and in part by UIC). Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 101st Annual Meeting of the American Association for Cancer Research; 2010 Apr 17-21; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2010;70(8 Suppl):Abstract nr 2947.
TCT-414 Angiographic predictive factors of vascular complications after transcatheter aortic valve implantation in patients treated with Prostar closure device
Authors: Manolis Vavuranakis, Maria Kariori, Vassilis Voudris, Konstantinos Kalogeras, Dimitrios Vrachatis, Carmen Moldovan, Sofia Thomopoulou, Konstantinos Aznaouridis, Constantina Masoura, George Lazaros, Christodoulos Stefanadis
Journal: Journal of the American College of Cardiology (2012)
Measurement of urinary chemokine and growth factor messenger RNAs: A noninvasive monitoring in lupus nephritis
Authors: Y. Avihingsanon, P. Phumesin, T. Benjachat, S. Akkasilpa, V. Kittikowit, K. Praditpornsilpa, J. Wongpiyabavorn, S. Eiam-Ong, T. Hemachudha, K. Tungsanga, N. Hirankarn
Journal: Kidney International (2006)
Fat absorption in pancreatic deficiency in rats.
Authors: J Masarei, W J Simmonds
Journal: Gut (1966)

EDITORIAL SYNOPSIS Bile or pancreatic juices are essential for the absorption of triglyceride from the small intestine but not for the absorption of fatty acid.In pancreatic fistula animals some lipolytic activity remains in the small intestine which might account for the absorption of some triglyceride.This absorption is improved by returning bicarbonate with bile salts to the small intestine.
Spain: a decentralised health system in constant flux
Authors: J. M Martin-Moreno, P. Alonso, A. Claveria, L. Gorgojo, S. Peiro
Journal: BMJ (2009)

The Spanish healthcare system is one of Europe's most efficient, but urgent reform is needed if it is to cope with changing demands and rising costs, argue <b>Jose M Martin-Moreno and colleagues</b>
Scintigraphic Cerebral Spinal Fluid Leak Study in a Child With Recurrent Meningitis After Resection of a Frontal Meningocele
Authors: RICHARD H. STERN, ITALO ZANZI, SUZANNE ROLAND, ALAN ROSENTHAL, PHILIP PERLMAN, DONALD MARGOULEFF
Journal: Clinical Nuclear Medicine (1995)

An In-111 DTPA cerebrospinal fluid (CSF) leak study was performed on a 3-year-old boy admitted with recurrent meningitis. He was born with a congenital encephalocele that was surgically resected at 7 days-of-age. A residual skull floor defect with a recurrent tumor of the nasal radix was clinically suspected. Computed tomography and MRI scans could not confirm or rule out the presence of a CSF leak. The scintigraphic study clearly demonstrated a leak into the left naris. A large leptomeningeal cyst extending down into the left nares was resected and a defect in the left frontal calvarium, identified as the source of the CSF leak, was repaired at surgery.
Effect of early propranolol treatment in an animal model of congestive cardiomyopathy. II. ss-adrenergic receptors and left ventricular function
Authors: N. A STALEY, G. R NOREN, S. EINZIG, T. G RUBLEIN
Journal: Cardiovascular Research (1984)

Young turkeys inbred for congestive cardiomyopathy (CCM) were treated with propranolol prior to the development of cardiac enlargement. One-day-old inbred CCM and commercial turkeys received 2 mg·kg−1·day−1 of propranolol for 1 month and were compared with untreated age matched inbred CCM and commercial turkeys. Heart weight, body weight, and binding characteristics of cardiac β-adrenergic receptors, using (−)3H-dihydroalprenolol as a ligand, were determined at 10 and 28 days. Left ventricular shortening fraction was determined at 28 days and at 32 days, 4 days after propranolol was discontinued, in treated and untreated inbred CCM and commercial turkeys. Propranolol did not prevent the development of cardiac hypertrophy in inbred CCM turkeys at 28 days of age and did not effect body weight or heart weight in either inbred CCM or commercial turkeys at 10 or 28 days of age. In the inbred CCM turkeys, the maximum number of binding sites (Bmax) and the binding affinity (Kd) of β-adrenergic receptors were not changed by propranolol treatment. In the propranolol-treated commercial turkeys, Bmax the of β-receptors was increased at 28 days of age compared with untreated age matched controls, 382 vs 194 fmol·mg−1 (p<0.05). Untreated inbred CCM turkeys when compared with untreated age matched commercial turkeys show a significant reduction of binding affinity of β-receptors at both 10 and 28 days of age, Kd= 10.4 vs 6.2 nmol·litre−1 at 10 days and 11.3 vs 5.2 nmol·litre−1 at 28 days (p<0.05). At 28 days of age Bmax in the CCM birds was significantly increased, 285 vs 194 fmol·mg−1 (p<0.05). Inbred CCM turkeys may have a lower responsiveness to catecholamines than commercial turkeys. Inbred CCM turkeys show decreased left ventricular shortening fraction at 28 days of age compared with commercial turkeys, 39± 12% vs 57±7% (p<0.01). The six propranolol-treated inbred CCM turkeys showed an improved left ventricular shortening fraction four days after the drug was stopped. The mean percentage change in left ventricular diameter rose from 33±12% to 47±6% (p<0.05). Chronic propranolol treatment depresses left ventricular function in inbred turkeys with congestive cardiomyopathy.
FamilyMD 2.4: A Primary Care Information Tool
Authors: Ray van Wolkenten
Journal: JAMA (1991)

<i>Family MD</i>is a user-friendly reference database for PC-compatible computers. Some topics are useful to family physicians, others less so. It is enjoyable but much too limited for use by the serious practitioner. A promised update may help. The program has four sections: "Topics," "Formulas," "Tools," and "Pharm." "Topics" contains brief narratives, lists, and flowcharts related to a variety of medical topics such as the evaluation of abnormal results on liver function tests or the differential diagnosis for alopecia. "Formulas" has seven common formulas, including calculation of anion gaps, body surface areas, and creatinine clearance. "Tools" includes an Acute Physiology and Chronic Health Evaluation (APACHE) II score
Association between Enterococcus bacteraemia and death in neutropenic patients with haematological malignancies
Authors: Giuseppe Todeschini, Cristina Tecchio, Carlo Borghero, Anna D'Emilio, Enrico Pegoraro, Fausto de Lalla, Paolo Benedetti, Paolo Spolaore, Giampietro Pellizzer
Journal: Journal of Infection (2006)
Bag Balm and Duct Tape: Tales of a Vermont Doctor
Authors: David J. Shulkin
Journal: JAMA (1989)

The public's appetite for stories about physicians seems endless. The themes are similar: "Doctors are real people too." In a book that follows suit, Dr Beach Conger shares his version of a medical career. He writes in the form of a professional diary that traces the metamorphosis of a native sophisticated New Yorker with scalpel and sharp pen and tongue into a kindly small-town Vermont family doctor whose patients teach him to practice the homey paternalistic brand of medicine of his elderly predecessor. The author states in the introduction that he believes the book will be read by both "sex fiends" and "serious readers," so he has annotated it throughout the text with sections of "Serious Reader Notes" to guide the serious readers, the sex fiends being left to "muddle along until they find what they are looking for." He writes that he was a shy, socially unskilled child and
Improved efficiency of treadmill exercise testing using a multiple lead ECG system and basic hemodynamic exercise response.
Authors: B R Chaitman, M G Bourassa, P Wagniart, F Corbara, R J Ferguson
Journal: Circulation (1978)

One hundred consecutive men with a normal ECG at rest had a maximal treadmill test using 14 leads during and post-exercise. Coronary arteriography performed the following day revealed coronary stenoses greater than or equal to 70% in 66 patients. Test results obtained from a V5 lead were compared to different lead combinations and were correlated with arteriographic findings. A positive exercise test occurred in 37 men using an isolated V5 lead compared to 50 men (P less than 0.05) using 11 leads, 52 men (P less than 0.05) using a combined CM5, CC5, Cl (inferior) lead system and 58 (P less than 0.001) men using all 14 leads. The predictive value of a positive test varied between 89-95% and was not changed significantly by the addition of multiple leads. The 14 lead ECG was positive in 43/45 (96%) patients with multivessel disease. Parameters which helped to predict multivessel disease using 14 leads were 1) the time that ischemia first appeared 2) the pressure-rate product at the time ischemia first appeared, and 3) the maximum workload that could be attained. In general, the magnitude of ST-segment depression and the time required for a positive ECG to return to normal postexercise were not useful predictors of multivessel disease. We conclude that the use of multiple leads improves the sensitivity and efficiency of the maximal treadmill exercise test. The usefulness of exercise test results can be further improved if multiple leads are combined with physiologic data collected during exercise.
Infected Cardiac Pacemaker Wires Demonstrated by Tc-99m Labeled White Blood Cell Scintigraphy
Authors: DOUGLAS M. HOWARTH, PETER G. CURTEIS, STUART GIBSON
Journal: Clinical Nuclear Medicine (1998)

Multiple cardiac pacing wires present a potential source of thrombosis and infection within veins and cardiac chambers. A case is presented where persistent infection involved thrombus on cardiac pacing wires in and around the right subclavian and brachiocephalic veins, which proved difficult to localize and treat. Early Ga-67 and Tc-99m labeled white blood cell imaging were negative but, when the latter test was repeated after 5 weeks, the septic focus was identified. Treatment with antibiotic therapy combined with surgical removal of the infected thrombus and both pacing wires was effective in eradicating infection. Failure to demonstrate an infection focus early in the course of the illness may have related to the size of the infection focus; however, in a later phase of the illness, Tc-99m labeled white blood cell imaging proved helpful in localizing focal infection associated with pacemaker wires.
Mechanisms of activation of the classical pathway of complement by Hageman factor fragment.
Authors: B Ghebrehiwet, B P Randazzo, J T Dunn, M Silverberg, A P Kaplan
Journal: Journal of Clinical Investigation (1983)

The mechanism by which a fragment of activated Hageman factor (HFf) activates the classical pathway of complement in serum or platelet-poor plasma has been further delineated. When serum or platelet-poor plasma was incubated with various concentrations of HFf, the total complement hemolytic activity was reduced in a dose-dependent manner. This activation appears to be due to the direct interaction of HFf with macromolecular C1, since incubation of purified C1 with HFf resulted in dissociation of the subunits with concomitant reduction of C1r antigenicity that is indicative of C1 activation. HFf-dependent activation was prevented by prior treatment of HFf with the active site-directed inhibitor, H-D-proline-phenylalanine-arginine chloromethyl ketone or with a specific inhibitor of activated HF derived from corn. Incubation of HFf with highly purified C1r also resulted in activation of C1r as assessed directly using a synthetic substrate or indirectly by activation of C1s and consumption of C2. However, incubation of HFf with highly purified C1s resulted in formation of activated C1s (C1s-) but this was less efficient than HFf activation of C1r. We therefore conclude that activation of C1 in macromolecular C1 is the result of HFf conversion of C1r to C1r; activation of C1s then occurs primarily by C-1r and to a lesser degree by the direct action of HFf.
Characterization and histologic localization of human growth hormone-variant gene expression in the placenta.
Authors: S A Liebhaber, M Urbanek, J Ray, R S Tuan, N E Cooke
Journal: Journal of Clinical Investigation (1989)

The human growth hormone-variant (hGH-V) gene is one of five highly similar growth hormone-related genes clustered on the short arm of chromosome 17. Although the pattern of expression of the adjacent normal growth hormone (hGH-N) and chorionic somatomammotropin (hCS) genes in this cluster are well characterized, the expression of the hGH-V gene remains to be defined. In previous studies, we have demonstrated that the hGH-V gene is transcribed in the term placenta and expressed as two alternatively spliced mRNAs: one is predicted to encode a 22-kD hormone (hGH-V), the other retains intron 4 in its sequence resulting in the predicted synthesis of a novel 26-kD hGH-V-related protein (hGH-V2). In the present report, we document the expression of both of these hGH-V mRNA species in the villi of the term placenta, demonstrate an increase in their concentrations during gestation, and directly sublocalize hGH-V gene expression to the syncytiotrophoblastic epithelium of the term placenta by in situ cDNA-mRNA histohybridization. The demonstrated similarity in the developmental and tissue-specific expression of the hGH-V gene with that of the related hCS gene suggests that these two genes may share common regulatory elements.
Modulation of VEGFR-2–mediated endothelial-cell activity by VEGF-C/VEGFR-3
Authors: Kazuyoshi Matsumura, Masanori Hirashima, Minetaro Ogawa, Hajime Kubo, Hiroshi Hisatsune, Nobuyuki Kondo, Satomi Nishikawa, Tsutomu Chiba, Shin-Ichi Nishikawa
Journal: Blood (2003)
Successful sustained engraftment after reduced-intensity umbilical cord blood transplantation for adult patients with severe aplastic anemia
Authors: Hisashi Yamamoto, Daisuke Kato, Naoyuki Uchida, Kazuya Ishiwata, Hideki Araoka, Shinsuke Takagi, Nobuaki Nakano, Masanori Tsuji, Yuki Asano-Mori, Naofumi Matsuno, Kazuhiro Masuoka, Koji Izutsu, Atsushi Wake, Akiko Yoneyama, Shigeyoshi Makino, Shuichi Taniguchi
Journal: Blood (2011)
Pancreatitis
Authors: James J. O'Brien, Theodore R. Thayer
Journal: New England Journal of Medicine (1955)

MANY articles on pancreatitis have dealt with the etiology,1 2 3 4 5 pathology,6 7 8 diagnosis9 10 11 12 13 and various forms of treatment.14 15 16 17 18 19 20 The purpose of this paper is to put more emphasis on the question of prognosis than has been done previously, as well as to comment on some unusual manifestations of the disease.MaterialBetween January 1, 1946 and December 31, 1952, 131 patients were treated for pancreatitis in the West Roxbury, Framingham and Boston Veterans Administration hospitals. For clinical convenience the cases have been classified as proved (108 patients) or presumptive (23 patients). To be placed in the former group a patient must have . . .
Enhanced Surveillance for Pregnancy-Associated Mortality—Maryland, 1993-1998
Authors: Isabelle L. Horon
Journal: JAMA (2001)

Deaths occurring among women who are pregnant or who have had a recent pregnancy have a devastating impact on the family and community. It is important to understand the magnitude and causes of pregnancy-associated mortality so that comprehensive strategies can be formulated to prevent such deaths.To ascertain the number and causes of pregnancy-associated deaths using enhanced surveillance techniques.Retrospective, cross-sectional analysis of death certificate data of reproductive-age women, live birth and fetal death records, and medical examiner records in Maryland during 1993-1998.Number of pregnancy-associated deaths, defined as death from any cause during pregnancy or within 1 year of delivery or pregnancy termination, by source of data and cause of death.A total of 247 pregnancy-associated deaths were ascertained. Twenty-seven percent (n = 67) were identified through cause-of-death information obtained from death certificates, 70% (n = 174) through linkage of death records with birth and fetal death records, and 47% (n = 116) through review of medical examiner records. Homicide was the leading cause of pregnancy-associated death (n = 50; 20%), and cardiovascular disorders were the second-leading cause (n = 48; 19%).In this Maryland sample, comprehensive identification of pregnancy-associated deaths was accomplished only after collecting information from multiple sources and including all deaths occurring up to 1 year after delivery or pregnancy termination. This enhanced pregnancy mortality surveillance led to the disturbing finding that a pregnant or recently pregnant woman is more likely to be a victim of homicide than to die of any other cause. By broadening pregnancy mortality to include all possible causes, previously neglected factors may assume increased importance in prenatal and postpartum care.