tbuckley/cabot-search huggingface dataset:
A case of sporadic Bazex?Dupr�?Christol syndrome presenting with scarring folliculitis of the scalp
Authors: T. Gambichler, S. Hoffjan, P. Altmeyer, F.G. Bechara
Journal: British Journal of Dermatology (2006)

Journal Article A case of sporadic Bazex–Dupré–Christol syndrome presenting with scarring folliculitis of the scalp Get access T. Gambichler, T. Gambichler Departments of Dermatology and Human Genetics, Ruhr‐University Bochum, Gudrunstr. 56, 44791 Bochum, Germany E‐mail: t.gambichler@klinikum‐bochum.de Search for other works by this author on: Oxford Academic Google Scholar S. Hoffjan, S. Hoffjan Departments of Dermatology and Human Genetics, Ruhr‐University Bochum, Gudrunstr. 56, 44791 Bochum, Germany E‐mail: t.gambichler@klinikum‐bochum.de Search for other works by this author on: Oxford Academic Google Scholar P. Altmeyer, P. Altmeyer Departments of Dermatology and Human Genetics, Ruhr‐University Bochum, Gudrunstr. 56, 44791 Bochum, Germany E‐mail: t.gambichler@klinikum‐bochum.de Search for other works by this author on: Oxford Academic Google Scholar F.G. Bechara F.G. Bechara Departments of Dermatology and Human Genetics, Ruhr‐University Bochum, Gudrunstr. 56, 44791 Bochum, Germany E‐mail: t.gambichler@klinikum‐bochum.de Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 156, Issue 1, 1 January 2007, Pages 184–186, https://doi.org/10.1111/j.1365-2133.2006.07580.x Published: 01 January 2007
The Role of Surgery in the Management of Lymphoma
Authors: John G. Allison
Journal: JAMA (1981)

WITHIN the field of cancer treatment, the most gratifying advances have probably been made in the lymphoma group, especially those of the Hodgkin's type; over the past two decades predicted survival rates have increased dramatically. Newer concepts and understanding of the Hodgkin's group of lymphomas have generated a cautiously optimistic attitude that Hodgkin's disease is eminently curable. Although the hematologistoncologist and radiotherapist bear the brunt of the management, the surgeon can contribute in a meaningful and positive way in both nodal and extranodal disease of all histological types. With this in mind, the classification, staging, and treatment of the lymphomas will be reviewed briefly, as will the role of surgery in the diagnosis, therapy, staging, and post-treatment restaging. <h3>PATHOLOGICAL CLASSIFICATION AND STAGING</h3> The diagnostic feature of Hodgkin's disease is the multinucleated Reed-Sternberg giant cell, with subtyping based on the ratio of other cell types (Table 1). With the exception of
Combined treatment of psoriasis with a new aromatic retinoid (Tigason) in low dosage orally and triamcinolone acetonide cream topically: a double-blind trial
Authors: H. J. RHEE, J. G. P. TIJSSEN, W. A. HERRMANN, A. H. WATERMAN, M. K. POLANO
Journal: British Journal of Dermatology (1980)

In a multicentre double‐blind trial the effect of three therapy regimens was studied for 6 weeks in ninety psoriasis patients: (1) aromatic retinoid (Ro 10‐9359) orally (0.50‐0.66 mg/kg body weight) and placebo cream topically; (2) aromatic retinoid (Ro 10‐9359) (same dosage) with 0.1% triamcinolone acetonide and 5% salicylic acid in lanette wax cream; (3) placebo capsules with 0.1% triamcinolone acetonide and 5% salicylic acid in lanette wax cream. Regimen 1 had virtually no effect and regimen 2 gave better results than regimen 3 for almost ail parameters, although statistical significance was reached for only some of them. The 6 week double‐blind period was followed by an open study in which all patients were treated according to regimen 2. The clinical result could be maintained up to the end of the study (18 weeks), when more than 60% of the patients showed good to excellent (80–100%) improvement. Most of the patients had dry lips, but generally without clinical symptoms of a cheilitis. The other well‐known side‐effects of retinoid were mild and relatively rare. It is concluded that the combination of the aromatic retinoid (Ro 10‐9359) given in low dosage orally with corticosteroids topically is as effective as therapy with the retinoid in high dosage alone, but with markedly less side‐effects.
Differential Diagnosis of the Electrocardiogram
Authors: Alfred Pick
Journal: JAMA (1961)

The authors of this recent addition to the many existing texts have chosen an original approach. The book is divided into four parts. The first part, illustrated by diagrams, introduces the reader to normal and abnormal electrophysiologic phenomena of the heart in a conventional manner. The second part is an atlas of basic normal and abnormal electrocardiographic patterns, each facing a short description. In the third part, extensive cross indexing permits ready consultation of pages in which particular abnormalities and their clinical significance are systematically discussed. The last part is a comprehensive index. There are no references. The prints are excellent, but the illustrative electrocardiograms appear either redrawn from originals or heavily retouched. The presentation reflects years of experience with practical clinical electrocardiography. Its potentialities and pitfalls are stressed. Most commendable are repeated reminders of the nonspecificity of many alterations and the need for serial tracings to arrive at a
COST-EFFECTIVENESS OF FOLLOW-UP OF INCIDENTAL LUNG NODULES DETECTED DURING CONTRAST ENHANCED CORONARY CTA IN PATIENTS WITH CHEST PAIN
Authors: Alexander Goehler, Pamela M. McMahon, Supriya Gupta, Mike Gilmore, Thomas J. Brady, G. Scott Gazelle, Udo Hoffmann, Quynh A. Truong
Journal: Journal of the American College of Cardiology (2011)
Kidney Disease in the Young
Authors: Eugene V. Perrin
Journal: JAMA (1972)

This inexpensively published book, written by a wise and well-known nephrologist, is a useful compendium of hard-to-obtain statistics, history, references, theoretical and practical considerations specifically related to pediatric kidney diseases. The volume is composed of a series of reviews of varying length and depth, some of which are busy rather than informative. Perhaps in an attempt to give the series of brief chapters some coherence, a rather conversational tone has been adopted from time to time, as if some of the chapters were dictated and not revised for uniform style. The data, many of the references, and some of the technical approaches to diagnosis are from previous generations of medical practice. The classical and exemplary content of many cases and references does not vitiate their importance or usefulness, but one has the feeling that file drawers are being emptied, issue by issue, so that every conceivable problem within the limits
Changes in intestinal absorption of nutrients and brush border glycoproteins after total parenteral nutrition in rats.
Authors: S Miura, S Tanaka, M Yoshioka, H Serizawa, H Tashiro, H Shiozaki, H Imaeda, M Tsuchiya
Journal: Gut (1992)

The effect of total parenteral nutrition on nutrients absorption and glycoprotein changes of brush border membrane was examined in rat small intestine. In total parenteral nutrition rats, a marked decrease in activity of brush border enzymes was observed mainly in the proximal and middle segments of the intestine. Galactose perfusion of jejunal segment showed that hexose absorption was significantly inhibited, while intestinal absorption of glycine or dipeptide, glycylglycine was not significantly affected by total parenteral nutrition treatment. When brush border membrane glycoprotein profile was examined by [3H]-glucosamine or [3H]-fucose incorporation into jejunal loops, significant changes were observed in the glycoprotein pattern of brush border membrane especially in the high molecular weight range over 120 kDa after total parenteral nutrition treatment, suggesting strong dependency of glycoprotein synthesis on luminal substances. Molecular weight of sucrase isomaltase in brush border membrane detected by specific antibody showed no significant difference, however, in total parenteral nutrition and control rats. Also, molecular weight of specific sodium glucose cotransporter of intestinal brush border membrane detected by selective photoaffinity labelling was not altered in total parenteral nutrition rats. It may be that prolonged absence of oral food intake may produce significant biochemical changes in brush border membrane glycoprotein and absorptive capacity of small intestine, but these changes were not observed in all brush border membrane glycoproteins.
Increased Nitric Oxide Output from Alveolar Origin during Liver Cirrhosis versus Bronchial Source during Asthma
Authors: CHRISTOPHE DELCLAUX, BRUNO MAHUT, FRANÇOISE ZERAH-LANCNER, CHRISTOPHE DELACOURT, SYLVA LAOUD, DANIEL CHERQUI, CHRISTOPHE DUVOUX, ARIANE MALLAT, ALAIN HARF
Journal: American Journal of Respiratory and Critical Care Medicine (2002)

The aim of this study was to assess the usefulness of nitric oxide (NO) output measurement at multiple expiratory flow rates during diseases characterized by increased exhaled NO (Fe NO) that could come from alveolar (liver cirrhosis) or bronchial (asthma) sources. It has been proposed that NO output measurements expressed as a function of expiratory flow allow alveolar NO concentration (Fa NO) and maximal bronchial NO output (Q˙br,max NO) to be computed. In 36 healthy nonsmoking subjects, we found that maximal bronchial NO output (37 ± 3 nl/min) was correlated with the height of the subjects (p = 0.02). Alveolar NO concentration was 5.1 ± 0.3 (SEM) ppb, which represented 31 ± 2% and 61 ± 3% of Fe NO at 50 and 200 ml/s expiratory flow rate, respectively. Nonsmoking subjects with asthma (n = 28) were characterized by an increase in Q˙br,max NO (133 ± 14 nl/min) as compared with healthy nonsmoking subjects (p < 0.0001). Fe NO50, Fe NO200, and Q˙br,max NO were equally efficient in differentiating subjects with asthma from healthy subjects. Patients with liver cirrhosis (n = 26, 14 smokers and 12 nonsmokers) had an increased Fa NO compared with healthy subjects (cirrhosis: 8.3 ± 0.9 ppb, healthy nonsmokers [n = 36] and smokers [n = 20], n = 56: 4.7 ± 0.3 ppb, p < 0.05), which was correlated with the alveolar–arterial oxygen difference (p = 0.007). Fa NO and Fe NO200, but not Fe NO50 values, allowed patients with liver cirrhosis to be differentiated from healthy subjects. These results suggest that a two-compartment model for NO output allows the increase in Fe NO from alveolar sources to be differentiated from the increase from bronchial sources.
Maternal Mortality in Massachusetts
Authors: Benjamin P. Sachs, Dick A.J. Brown, Shirley G. Driscoll, Erica Schulman, David Acker, Bernard J. Ransil, John F. Jewett
Journal: New England Journal of Medicine (1987)

To identify ways in which the safety of childbirth might be increased, we investigated the causes of death among the 886 women who died during pregnancy or within 90 days post partum ("maternal deaths") in Massachusetts from 1954 through 1985. The maternal mortality rate declined from 50 per 100,000 live births in the early 1950s to the current rate of 10 per 100,000 live births. Between one third and one half of the maternal deaths were considered to have been preventable. The leading causes of maternal death from 1954 through 1957 were infection, cardiac disease, pregnancy-induced hypertension, and hemorrhage. In contrast, from 1982 through 1985 the leading causes of death were trauma (suicide, homicide, and motor vehicle accidents) and pulmonary embolus. We observed a rapid increase in the frequency of death among women who received little or no antenatal care. From 1980 through 1984 the maternal mortality rate for white women was 9.6 per 100,000 live births, whereas for nonwhites it was 35 per 100,000 live births (relative risk, 2.9; 95 percent confidence limits, 2.5 and 3.2). Fifty percent of the nonwhite women who died during pregnancy or within 90 days post partum received little or no antenatal care, in contrast to only 15 percent of the white women. These data show that the leading causes of maternal death have changed markedly in Massachusetts during the past 30 years. Although the overall maternal mortality rate has declined sharply, further improvement may occur with better antenatal care and specific efforts to prevent trauma and pulmonary embolus.
Donor Funding for Newborn Survival: An Analysis of Donor-Reported Data, 2002–2010
Authors: Catherine Pitt, Joy E. Lawn, Meghna Ranganathan, Anne Mills, Kara Hanson
Journal: PLoS Medicine (2012)

Neonatal mortality accounts for 43% of global under-five deaths and is decreasing more slowly than maternal or child mortality. Donor funding has increased for maternal, newborn, and child health (MNCH), but no analysis to date has disaggregated aid for newborns. We evaluated if and how aid flows for newborn care can be tracked, examined changes in the last decade, and considered methodological implications for tracking funding for specific population groups or diseases.We critically reviewed and categorised previous analyses of aid to specific populations, diseases, or types of activities. We then developed and refined key terms related to newborn survival in seven languages and searched titles and descriptions of donor disbursement records in the Organisation for Economic Co-operation and Development's Creditor Reporting System database, 2002-2010. We compared results with the Countdown to 2015 database of aid for MNCH (2003-2008) and the search strategy used by the Institute for Health Metrics and Evaluation. Prior to 2005, key terms related to newborns were rare in disbursement records but their frequency increased markedly thereafter. Only two mentions were found of "stillbirth" and only nine references were found to "fetus" in any spelling variant or language. The total value of non-research disbursements mentioning any newborn search terms rose from US$38.4 million in 2002 to US$717.1 million in 2010 (constant 2010 US$). The value of non-research projects exclusively benefitting newborns fluctuated somewhat but remained low, at US$5.7 million in 2010. The United States and the United Nations Children's Fund (UNICEF) provided the largest value of non-research funding mentioning and exclusively benefitting newborns, respectively.Donor attention to newborn survival has increased since 2002, but it appears unlikely that donor aid is commensurate with the 3.0 million newborn deaths and 2.7 million stillbirths each year. We recommend that those tracking funding for other specific population groups, diseases, or activities consider a key term search approach in the Creditor Reporting System along with a detailed review of their data, but that they develop their search terms and interpretations carefully, taking into account the limitations described. Please see later in the article for the Editors' Summary.
Scanning for Uremic Pulmonary Calcifications
Authors: BEVERLY A. DAVIS
Journal: Annals of Internal Medicine (1976)

Comments and Corrections1 July 1976Scanning for Uremic Pulmonary CalcificationsBEVERLY A. DAVIS, M.D., KATTADIYIL P. POULOSE, M.D., RICHARD C. REBA, M.D.BEVERLY A. DAVIS, M.D.Search for more papers by this author, KATTADIYIL P. POULOSE, M.D.Search for more papers by this author, RICHARD C. REBA, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-85-1-132_1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: We do not agree with Drs. Conger and Alfrey's reply (Ann Intern Med84:224-225, 1976) to the proposed value of obtaining99mTc-pyrophosphate (99mTcPP) scans in chronic uremic patients to demonstrate pulmonary calcifications. We have seen two patients who showed diffuse pulmonary parenchymal accumulation of99mTcPP with normal chest roentgenographs. There were no predisposing causes for pulmonary calcifications except uremia. Thus our observations support those of Drs. Moinuddin, Rockett, and Weber (Ann Intern Med84:224, 1976) that99mTcP scanning may be of value in finding diffuse pulmonary calcification in uremic patients with normal chest radiographs. The following case... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Department of Nuclear Medicine Washington Hospital Center Washington, D.C. 20010 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byRenal osteodystrophyExtensive Peritoneal Calcification as a Complication of Long Term CAPDRenal Osteodystrophy and Maintenance DialysisGeneralized soft tissue calcification in children and adolescents with end stage renal failureDiffuse pulmonary uptake of 99mTc bone-imaging agents: Case report and surveyLung calcification in long-term dialysed patients: a light and electronmicroscopic studyRenal Osteodystrophy and Maintenance DialysisRenal osteodystrophyPulmonary calcification in hemodialyzed patients detected by technetium-99m diphosphonate scanningRenal Osteodystrophy and Maintenance DialysisRenal Osteodystrophy 1 July 1976Volume 85, Issue 1Page: 132-132KeywordsThorax Issue Published: 1 July 1976 PDF downloadLoading ...
Narrative Review: Ketosis-Prone Type 2 Diabetes Mellitus
Authors: Guillermo E. Umpierrez, Dawn Smiley, Abbas E. Kitabchi
Journal: Annals of Internal Medicine (2006)

Several investigators have reported that more than half of African-American persons with new diagnoses of diabetic ketoacidosis have clinical, metabolic, and immunologic features of type 2 diabetes during follow-up. These patients are usually obese, have a strong family history of diabetes, have a low prevalence of autoimmune markers, and lack a genetic association with HLA. Their initial presentation is acute, with a few days to weeks of polyuria, polydipsia, and weight loss and lack of a precipitating cause of metabolic decompensation. At presentation, they have markedly impaired insulin secretion and insulin action, but intensified diabetic management results in significant improvement in beta-cell function and insulin sensitivity sufficient to allow discontinuation of insulin therapy within a few months of follow-up. On discontinuation of insulin therapy, the period of near-normoglycemic remission may last for a few months to several years. The absence of autoimmune markers and the presence of measurable insulin secretion have proven useful in predicting near-normoglycemic remission and long-term insulin dependence in adult patients with a history of diabetic ketoacidosis. This clinical presentation is commonly reported in African and African-American persons but is also observed in Hispanic persons and those from other minority ethnic groups. The underlying mechanisms for beta-cell dysfunction in ketosis-prone type 2 diabetes are not known; however, preliminary evidence suggests an increased susceptibility to glucose desensitization.
WT1 peptide analogue WT1-126Y enhances leukemia lysis
Authors: Ghofran Alqudaihi, Cynthia Lehe, Monther Al-Alwan, Hazem Ghebeh, Anne Dickinson, Said Dermime
Journal: Journal for ImmunoTherapy of Cancer (2014)

Meeting abstracts The Wilms Tumour Antigen 1 (WT1) has been shown to be expressed at low levels in some normal cells. Therefore, many of the potential CTL epitopes against this antigen may be absent or suboptimal. To this end, different groups introduced modifications in the sequence of the anchor
Comparison of characteristics of patients and treatment outcome for pulmonary non-tuberculous mycobacterial infection and pulmonary tuberculosis.
Authors: N. Al Jarad, P. Demertzis, D. J. Jones, N. C. Barnes, R. M. Rudd, H. Gaya, J. A. Wedzicha, D. T. Hughes, D. W. Empey
Journal: Thorax (1996)

Patients with non-tuberculous mycobacteria are usually started on conventional antituberculous triple therapy once acid fast bacilli are detected, before the exact type of mycobacteria has been identified. The ability to identify the characteristics of patients with tuberculous and non-tuberculous mycobacteria may be helpful in identifying before treatment those patients more likely to have non-tuberculous infection.A retrospective study was conducted of all patients in one unit in whom non-tuberculous mycobacteria were identified in sputum or bronchoalveolar washings in the period 1987-93. The pattern of drug resistance was determined from laboratory records, and all case notes and chest radiographs were reviewed to identify the underlying disease and treatment outcome. All cases were compared with a matched control group of patients with culture positive Mycobacterium tuberculosis diagnosed during the same period.In the period studied there were 70 non-tuberculous and 221 tuberculous isolates. The non-tuberculous bacteria were typed as follows: M xenopi 23 (33%), M kansasii 19 (27%), M fortuitum 14 (20%), others 14 (20%). Of those with non-tuberculous mycobacteria, 83% were white subjects compared with 47% for tuberculosis. Patients with non-tuberculous mycobacteria were older than those with tuberculosis. Pre-existing lung disease or AIDS was present in 81% of patients with non-tuberculous mycobacteria and in 17% of patients with tuberculosis. Sensitivity to rifampicin and ethambutol was seen in 95% of M xenopi and 96% of M kansasii isolates. Relapse occurred in 60% of cases infected with M xenopi, 20% infected with M kansasii, and in 7% of cases with tuberculosis.In the population studied non-tuberculous mycobacteria occurred most frequently in elderly white subjects with pre-existing lung disease. If mycobacteria are detected in this group, consideration should be given to the possibility of non-tuberculous infection before embarking on treatment. A combination containing rifampicin and ethambutol is effective. The relapse rate for infection with M xenopi is high and prospective studies of the effect of the above combination of antituberculosis drugs are needed.
Modified muscle sparing posterolateral thoracotomy.
Authors: M Ashour
Journal: Thorax (1990)

A modified posterolateral thoracotomy is described that combines the advantages of complete muscle sparing through a thoracolumbar fascial slide with excellent exposure. The technique is easy to perform. The procedure was associated with relatively little postoperative pain, coughing was effective, and early ambulation was achieved. Experience with this approach in the first 49 patients suggests that it offers an attractive alternative to the standard muscle cutting posterolateral thoracotomy approach for elective procedures.