tbuckley/cabot-search huggingface dataset:
Emergency Medicine: A Comprehensive Review.
Authors: Thomas Clarke Kravis, Carmen Germaine Warner
Journal: Annals of Internal Medicine (1991)

Section 1: Organization and Delivery of Emergency Medical Care Systems Approach Prehospital Care Hospital Care Disaster Management Emergency Care and the Law Section II: Shock and Trauma Shock Management of the Multisystem-injured Patient Transfusions Minor Lacerations and Abrasions Section III: Orthopedic Emergencies Muscoskelatal Emergencies: Introduction and Basic Principles Emergencies of the Vertebral Column Upper Extremity Emergency Problems Pelvis and Lower Extremity Fracture Management Section IV: Metabolic, Endocrine, and Genetic Emergencies Diabetic Emergencies Thyroid Disorders Adrenal Insufficiency Electrolyte Abnormalities Hypokalemia and Hyperkalemia Hypomagnesia and Hypermagnesia Hypercalcemia Acid-Base Disturbances Emergencies in Patients with Connective Tissue Disease Acute Monoarticular Arthritis Medical Genetics Section V: General Emergencies Infectious Disease Emergencies Bums Dermatologic Emergencies Gastrointestinal Emergencies Poisoning, Drug Overdose, and Toxic Exposures Hazardous Materials Occupational Toxicologic Emergencies Section VI: Pediatric Emergencies CPR Shock Syndromes in Children Anaphylaxis Evaluation of Febrile Children Under 2 Years of Age Reyes Syndrome Emergency Management of Seizure Disorders Pediatric Dehydration Pediatric Respiratory Emergencies: Small Airway Disorders Management of Gastrointestinal Foreign Bodies in Children Child Abuse Sexual Abuse Section VII: Environmental Emergencies Bites and Stings Hyperthermia Hypothermia Altitude-Related Emergencies Drowning and Near-Drowning Diving Emergencies Hyperbaric Emergencies Dangerous Marine Organisms Section VIII: Psychosodal Emergencies Substance Abuse Alcohol Abuse Depression and Suicidal Feelings and Behaviors Domestic Violence Oncology in the Emergency Room Emotional and Spiritual Support Pain Management Section IX: Alterations of Central Nervous System Functions Head Injuries Section X Alterations of Circulatory System Functions Section XI: Alterations of Respiratory System Functions Airway Management Upper Airway Obstruction Obstructive Airways Disease Pulmonary Embolism Respiratory-Failure.. Miscellaneous Respiratory Emergencies Chest Trauma Section XII: Alterations In Urinary and Reproductive Function Common Genitourinary Emergencies Renal Failure Obstetric and Gynecologic Emergencies Rape and Sexual Assault Section XIII: Head and Neck Injuries Ocular Emergencies Ear, Nose, and Throat Emergencies Laryngeal Emergencies Maxillofacial Injuries Dental Emergencies Section XIV Practical Applications of Emergency Care Atlas of Emergency Prooed u res Emergence Drug Index.
Ebola Vaccine Progress
Authors: Joan Stephenson
Journal: JAMA (2001)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Respiratory endurance testing in healthy children
Authors: Christian Bieli, Rahel Bosshard, Andreas Jung, Alexander Moeller
Journal: European Respiratory Journal (2014)

Background   A respiratory endurance test (RET) that allows hyperventilation without decrease of arterial carbon dioxid (CO 2 ) has been used in adult subjects to assess respiratory endurance. Until now, this test has never been performed with healthy children.   Methods   A total of 83 subjects 10 to 12 years old participated in this study. The RET was performed with the SpiroTiger®, a device that allows hyperventilation without decrease in arterial CO 2 . In order to assess endurance performance, a 6 min running test was performed and the physical activity was measured by an accelerometer. The aim of the study was to analyze the feasibility of a RET in school children. Furthermore, the relationship between the respiratory endurance and the endurance performance as well as the physical activity was investigated.   Results   Median and interquartile range for respiratory endurance was 199 s and 155 s. There was a trend for boys to have a higher respiratory endurance (p = 0.069). Respiratory endurance was independent of lung function and physical activity. There is no correlation between respiratory endurance and the endurance performance for boys (r = 0.233, p = 0.232) or girls (r = 0.248, p = 0.171).   Conclusion   We have shown that the respiratory endurance test performed with the SpiroTiger® is feasible in healthy children 10 to 12 years old. Reference data for the RET in this age group will be presented at the congress.
Abstract 12830: Prognostic Significance of the Right Ventricular Dimension on Acute Decompensation in Chronic Left-sided Heart Failure
Authors: Emi Maekawa, Takayuki Inomata, Ichiro Watanabe, Tomoyoshi Yanagisawa, Tomohiro Mizutani, Hisahito Shinagawa, Toshimi Koitabashi, Ichiro Takeuchi, Tohru Izumi
Journal: Circulation (2010)

Introduction:  Although many reports have shown that right ventricular (RV) function in the compensatory phase has prognostic significance of chronic heart failure (HF), there have been few reports investigating its clinical significance on acute exacerbation.   Methods:  One hundred and twenty-three consecutive patients (67±15 yo, 95 men) admitted for dyspnea derived from exacerbated left-sided HF with a left ventricular ejection fraction (LVEF)    Results:  There were 14 cardiac deaths during the median follow-up of 422 days after admission. Multivariate analysis revealed that RVDd on admission (hazard ratio 1.109, p   Conclusion:  Enlarged RVDd on HF exacerbation predicted a worse long-term prognosis of left-sided HF presumably through facilitated low cardiac output.
New Type 2 Diabetes Drugs
Authors: Jane E. Henney
Journal: JAMA (1999)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Investigation and treatment of thyroglossal cysts in children
Authors: C Brewis, M Mahadevan, C M Bailey, D P Drake
Journal: Journal of the Royal Society of Medicine (2000)

Thyroglossal cysts are the commonest midline neck masses in children. To evaluate current practice questionnaires were sent to all ear, nose and throat (ENT) and paediatric surgeons in the UK and 72% responded. The commonest investigation requested was an ultrasound scan (54%) and the commonest operation was a variant of Sistrunk's procedure (78%). Paediatric surgeons did fewer investigations than ENT surgeons and tended to excise more of the thyroglossal tract. Review of the published work suggests that ultrasound scanning and Sistrunk's procedure are the best management policy. The scan can avoid inadvertent excision of an ectopic thyroid gland. Extensive thyroglossal tract excisions give lower recurrence rates.
Abstract P097: Maternal Vascular Changes during Pregnancy may Persist Postpartum
Authors: Nancy A Niemczyk, Emma Barinas-Mitchell, Janet M Catov, Candace K McClure, James M Roberts, Akira Sekikawa, Ping G Tepper
Journal: Circulation (2014)

Introduction: Higher parity (number of births) is associated with increased subclinical cardiovascular disease (CVD) in mid-life and older women, and with increased risk of CVD overall. In the only study of reproductive age women, common carotid artery intima-media thickness (CCA IMT) was greater after each birth. Prospective studies of arterial change throughout normal pregnancy are lacking; without them it is unclear whether unhealthy changes of the vasculature during pregnancy persist postpartum and raise women’s risk of CVD. The goal of this study was to prospectively assess normal vascular adaptation in healthy pregnant women. Hypotheses: During the course of healthy pregnancy: 1. CCA adventitial diameter (AD) will increase, then return to baseline postpartum, 2. CCA IMT will initially thin, then thicken as pregnancy progresses, then return to baseline postpartum, and 3. brachial artery distensibility will not change. Methods: We assessed 43 healthy women during each trimester of their first pregnancy and 6-8 weeks postpartum with B-mode ultrasound imaging of the CCA IMT and AD, independent predictors of CVD risk. Brachial artery distensibility, representing elasticity of the artery, was measured using the DynaPulse wave form analyzer. Linear mixed models were used to compare measures of CCA IMT, adventitial diameter, and brachial artery distensibility at each time point, after adjustment for age and pre-pregnancy BMI. Results: There were 37 women (age 28.2 ± 4.5 years, pre-pregnant BMI 24.4 ± 3.2 kg/m 2 ) with uncomplicated pregnancies. Six women with pregnancy complications were excluded from these analyses. After adjustment for age and pre-pregnancy BMI, mean (SE) CCA AD (mm) increased each trimester, from 6.38(0.08) in the 1 st trimester to 6.92(0.09) in the 3 rd trimester, and returned to baseline, 6.35 (0.07), postpartum. Pairwise comparisons were all statistically significant at p&lt;.01. Mean (SE)CCA IMT (mm) was increased postpartum (0.567 (0.01)) compared to 1 st (0.539 (0.01)) and 2 nd trimester values (0.546 (0.01), p &lt; .05 for each). Mean (SE) brachial artery distensibility (%/mmHg) decreased from 7.64 (0.28) 1st trimester to 6.84 (0.21) 3rd trimester (p &lt; .01) and then remained unchanged at 6.82 (0.21) postpartum. Conclusions: As we hypothesized, in uncomplicated first pregnancies CCA AD increased throughout and returned to baseline postpartum. However, contrary to our hypotheses, CCA IMT increased postpartum, and the brachial artery stiffened during pregnancy and remained stiffer 6-8 weeks postpartum. In uncomplicated first pregnancies, some vascular changes resolved (CCA AD) and others persisted (CCA IMT and brachial artery stiffness). Whether this indicates that persistence of specific vascular effects of pregnancy may inform long term CVD risk remains to be explored.
ULCERATIV'E CUTANEOUS LESIONS IN SARCOIDOSIS.
Authors: S. IRGANG
Journal: British Journal of Dermatology (1955)

Journal Article ULCERATIV'E CUTANEOUS LESIONS IN SARCOIDOSIS: Report of a Case with Clinical Resemblance to Papuloneerotic Tuberculide. Get access S. IRGANG, M.D. S. IRGANG, M.D. Department of Dermatology and Syphilology of the Harlem Hospital, Now York Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 67, Issue 7, 1 July 1955, Pages 255–260, https://doi.org/10.1111/j.1365-2133.1955.tb12731.x Published: 01 July 1955
Co-inhibition of IGF-1R and PDGFR synergistically inhibit proliferation in GB cells and induce radiosensitivity in JNK-expressing glioblastoma cells
Authors: Mia Carapancea, Anica Dricu
Journal: Cancer Research (2006)

Proc Amer Assoc Cancer Res, Volume 47, 2006

5182 

Increased expression and activation of receptor tyrosine kinases (RTKs) frequently occurs in human brain tumors, mediating a variety of growth-promoting pathways and leading to radioresistance. In this study, we found co-expression of IGF-1R and PDGFR in two glioblastoma (GB) cell lines (18KJ40, 38JL59). Dual targeting of IGF-1R and PDGFR caused synergy in cell death in both 18KJ40 and 38JL59cell lines. In addition, co-inhibition of of IGF-1R and PDGFR incresed radiosensitivity in 18KJ40 cells but failed to intensify the effect of radiation in 38JL59 cells. To dissect which of the radiation-responsive signaling pathways elicited by membrane receptors may be responsable for observed differences, we investigate the phosphoinositide 3-kinase (PI3-K) and MAPK kinases (ERK1/2 and c-Jun-NH2-terminal kinase 1 (JNK1)) pathway. PI3-K and ERK1/2 were expressed in both glioblastoma cell lines while JNK1/3 was expressed only in 18KJ40 cells. Ionizing radiation exposure induced JNK activation in 18KJ40 suggesting that radiation-activated JNK may provide an anti-proliferative signalling, parallel to receptors co-targeting, in this cell line. To test this hypothesis, GB cells were treated with dominant negative JNK1 (dnJNK), a specific inhibitor of JNK and the response to radiation was assayed in presence or absence of receptors co-inhibition. Our results showed that, in each treatment conditions, dnJNK protects 18KJ40 cells against γ-irradiation -induced cell death. As would be expected, dnJNK treatment failed to influence radiation response of the 38JL59 cell line, which did not express JNK. Functionally, we found that dual targeting of IGF-1R and PDGFR caused synergystic cell death in GB cell lines and incresed radiosensitivity in JNK-expressing GB cells but had no effect with γ-irradiation in JNK deficient glioblastoma cells.
Critical Care Cardiology.
Authors: Robert J. Henning, Ake Grenvik
Journal: Annals of Internal Medicine (1981)

Cardiovascular Monitoring in the Critically Ill. Diagnosis and Treatment of Cardiac Arrythmias. Current Management of Hypertensive Emergencies. Diagnosis and Treatment of Aortic Dissection. Congenital Heart Disease in the Adult. Adult Valvular Disease. Endocarditis. Thrombolytic Therapy and Coronary Angioplasty in Evolving Acute Myocardial Infarction. The Diagnosis and Treatment of Patient with Acute Myocardial Infarction. Surgery for the Acute Complications of Myocardial Infarction. Injury to the Heart and Great Vessels. Temporary Circulatory Support with Assist Devices and the Total Artificial Heart. Heart Transplantation
Experts Weigh Prevention, Therapy for Ocular Vaccinia in Smallpox Vaccinees
Authors: Brian Vastag
Journal: JAMA (2003)

As for the third barrier, O’Brien said that until recently, imaging technology was unable to detect aortic sclerosis, which is thought to be the asymptomatic precursor of hemodynamically significant aortic stenosis. But that has changed with advent of electron beam tomography (EBT). Now clinicians have a tool to monitor aortic valve pathology in vivo and perhaps offer treatment prior to onset of aortic stenosis. (In this issue, researchers present results from a study evaluating the use of coronary artery calcification screening by EBT to motivate patients to reduce coronary heart disease risk factors. See page 2215 and an accompanying editorial on page 2270.) “Echocardiography can monitor progression in the late stage of the disease,” O’Brien said. “But what about the three decades prior when it’s growing in a patient? This may be a good time to target the disease with therapy. But you have to measure it, and now we can.” So while O’Brien’s second barrier has yet to be breached, many researchers are now calling for large randomized therapeutic trials to determine the correct approach to treating aortic sclerosis and stenosis. “The time is right for clinical trials,” said Robert O. Bonow, MD, president of the American Heart Association. “But these trials will be difficult to conduct because the risk factors for aortic valve calcification appear to be the same for atherosclerosis, so your subject population may already be on an ACE inhibitor or statin.” For these reasons, Rajamannan said a placebo-controlled trial would be inappropriate. “We’re hoping for a prospective trial where we randomize perhaps to low and high dose of statin therapy to see what is needed to reduce this progression,” Rajamannan said. Another question centers around the uniqueness of the potential patient populations who may benefit from statin or ACE inhibitor therapy. After all, a large percentage of patients at various stages of risk for cardiovascular disease will already be receiving medical therapy—the same treatment proposed for aortic stenosis. O’Brien said he is not convinced the populations will be the same. “If you define atherosclerosis as having obstruction to blood flow in the arteries, then there’s not a great relationship between that and aortic stenosis,” O’Brien said. “So it’s not a perfect correlation that everyone with calcific aortic valve disease also has cardiovascular disease.” For Rajamannan, even if the two populations are shown to benefit from the same medical therapies, prospective trials are needed to fine-tune such treatment. “These populations need to be defined, and we need guidelines for treatment of aortic sclerosis,” Rajamannan said.
Abstract 16570: Respiratory Ciliary Motion Defect Predict Regional Brain Abnormalities and Increased Extra Axial CSF Fluid in Neonates With Complex Congenital Heart Disease
Authors: Ashok Panigrahy, Rafael Ceschin, Vince Lee, Nancy Beluk, Omar Khalifa, Giulio Zuccoli, Ricardo Munoz, Yuliya Domnina, Peter Wearden, Victor Morell, Maliha Zahid, Cecilia W Lo
Journal: Circulation (2014)

Objectives:  We hypothesized congenital heart disease (CHD) patients with respiratory ciliary motion (CM) defects may have increased prevalence of brain abnormalities.   Background:  We recently showed CHD patients have a high prevalence of airway motile cilia dysfunction. In the brain, motile cilia in the ependyma mediate cerebrospinal fluid (CSF) flow required for neuronal cell migration/neurogenesis. Cilia are also found in the choroid plexus and are required for maintenance of neural progenitors. CHD patients with airway motile ciliary dysfunction may be at increased risk of neurocognitive abnormalities.   Methods and Results:  40 neonates with complex CHD underwent preoperative cranial US, volumetric MRI and respiratory ciliary motion (CM) assessment with high-speed videomicroscopy of nasal biopsies. CM was scored on a scale of 1 to 4, with 1 indicating normal CM, ranging to 4 for highly abnormal CM. Multivariate logistical regression of brain measurements with CM scores revealed significant correlation between respiratory CM defects and brain abnormalities (right panel, p   Conclusions:  Airway ciliary dysfunction is associated with structural brain abnormalities in neonates with complex CHD including: (1) subtle brain dysplasia in the olfactory bulb/hippocampus; (2) choroid plexus abnormalities and (3) increased extra-axial CSF fluid. These clinical translational studies suggest a potential unifying role for the cilia in contributing to both structural heart disease and brain abnormalities in CHD patients.
Functional haploinsufficiency of the human homeobox gene MSX2 causes defects in skull ossification
Authors: Andrew O.M. Wilkie, Zequn Tang, Navaratnam Elanko, Sinead Walsh, Stephen R.F. Twigg, Jane A. Hurst, Steven A. Wall, Krystyna H. Chrzanowska, Robert E. Maxson
Journal: Nature Genetics (2000)
Reply to Westerman et al.: ‘Re: Essential thrombocythemia in young individuals: frequency and risk factors for vascular events and evolution to myelofibrosis in 126 patients. Alvarez-Larrán A et al. Leukemia 2007; 21: 1218–1223’
Authors: A Alvarez-Larrán, F Cervantes, C Besses
Journal: Leukemia (2007)
Enhancing the Efficacy of T Cell Receptor (TCR) Gene Therapy by Co-Transfer of TCR and Additional CD3 Molecules Into CD4+ T Cells
Authors: Emma K Nicholson, Maryam Ahmadi, Angelika Holler, Rebecca Pike, Ben Carpenter, Sharyn Thomas, Sara Ghorashian, Shao-An Xue, Hans Stauss, Emma Morris
Journal: Blood (2012)
Can children and young people consent to be tested for adult onset genetic disorders? Commentary: Weighing burdens and benefits rather than competence
Authors: D. L Dickenson, G. Geller
Journal: BMJ (1999)

# Can children and young people consent to be tested for adult onset genetic disorders? {#article-title-2}

What should we do about children and young people who want to be tested for incurable, adult onset, genetic disorders? In particular, what should a general practitioner do if he or she believes the young person is competent to decide, but the regional genetics unit refuses to test anyone under 18? In this article I discuss such a case (drawn from actual practice, but anonymised), and consider the arguments for and against allowing the young person to be tested in terms of good practice, case and statute law, empirical evidence, and ethics.



Consider the following case. As a general practitioner, you are confronted with Alison, an intelligent 15 year old girl whose father has recently tested positive for Huntington's disease. His own mother died of the condition before Alison was born. Alison wants to know whether she too will develop Huntington's disease. Her parents, who have accompanied her to the surgery, support her wish. Alison's mother is herself contemplating genetic testing for the BRCA1 gene implicated in some breast cancers, because her mother and elder sister died from the disease. You know that the clinical genetics unit serving your patients will not test anyone under 18, although Alison can have counselling. You point out that according to the unit's careful protocol even those over 18 must undergo counselling …
Identifying Dead Artists
Authors: Joseph Geskey
Journal: JAMA (1998)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal