STREPTOCOCCAL ANTIHYALURONIDASE TITERS IN THE SERA OF PATIENTS WITH RHEUMATOID ARTHRITIS AND GLOMERULONEPHRITIS
Authors: T N HARRIS, S HARRIS, A M DANNEBERG, J L HOLLANDER
Journal: Annals of Internal Medicine (1950)

Article1 May 1950STREPTOCOCCAL ANTIHYALURONIDASE TITERS IN THE SERA OF PATIENTS WITH RHEUMATOID ARTHRITIS AND GLOMERULONEPHRITIST. N. HARRIS, M.D., SUSANNA HARRIS, Ph.D., A. M. DANNENBERG JR., M.D., J. L. HOLLANDER, M.D., F.A.C.P.T. N. HARRIS, M.D.Search for more papers by this author, SUSANNA HARRIS, Ph.D.Search for more papers by this author, A. M. DANNENBERG JR., M.D.Search for more papers by this author, J. L. HOLLANDER, M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-32-5-917 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptRecent observations on streptococcal antihyaluronidase in human sera have shown that the concentration of that antibody is elevated above the normal in acute rheumatic and streptococcal infection. Within the clinical groups mentioned it has been found that the mean antihyaluronidase titer is higher in acute rheumatic fever than following streptococcal infections, and that the range of such titers in the former disease extends above the range found in the latter.1, 2, 3, 4These observations have directed interest to the question of antibody levels to this streptococcal enzyme in two other diseases: glomerulonephritis, because of its similarity to rheumatic fever...Bibliography1. Quinn RW: Antihyaluronidase studies of sera from patients with rheumatic fever. streptococcal infections, and miscellaneous non-streptococcal diseases, J. Clin. Invest. 27: 471, 1948. CrossrefMedlineGoogle Scholar2. HarrisHarris TNS: Studies in the relation of the hemolytic streptococcus to rheumatic fever. V. Streptococcal antihyaluronidase (mucin-clot-prevention) titers in the sera of patients with rheumatic fever, streptococcal infection, and others, Am. J. M. Sc. 217: 174, 1949. CrossrefMedlineGoogle Scholar3. HarrisHarrisNagle TNSR: Studies in the relation of the hemolytic streptococcus to rheumatic fever. VI. Comparison of streptococcal antihyaluronidase with antibodies to other streptococcal antigens in the serum of patients with rheumatic fever and acute streptococcal infection: mucin-clot-prevention test, Pediatrics 3: 482, 1949. MedlineGoogle Scholar4. Friou GJ: Further observations of an inhibitor in human serums of the hyaluronidase produced by a strain of hemolytic streptococcus, J. Infect. Dis. 84: 240, 1949. CrossrefMedlineGoogle Scholar5. Tillett WS: The occurrence of antifibrinolytic properties in the blood of patients with acute hemolytic streptococcal infections, J. Clin. Invest. 14: 276, 1935. CrossrefMedlineGoogle Scholar6. Boisvert PL: The streptococcal antifibrinolysin test in clinical use, J. Clin. Invest. 19: 65, 1940. CrossrefMedlineGoogle Scholar7. Winblad S: Studies in hemolytic streptococcal fibrinolysin, antifibrinolysin and antistreptolysin, with particular reference to rheumatic fever, Acta. path. Scandinav. 1941, Supp. 44. Google Scholar8. BlairHallman JEFA: Streptococcal agglutinins and antistreptolysins in rheumatoid arthritis, J. Clin. Invest. 14: 505, 1935. CrossrefMedlineGoogle Scholar9. McEwenBunimAlexander CJJRC: Bacteriologic and immunologic studies in arthritis. III. Results of various immunologic tests in different forms of arthritis, J. Lab. and Clin. Med. 21: 465, 1936. Google Scholar10. KeeferMyersOppel CSWKTW: Streptococcal agglutinins in patients with rheumatoid arthritis and rheumatic fever, J. Clin. Invest. 12: 267, 1933. CrossrefMedlineGoogle Scholar11. Wallis AD: Rheumatoid arthritis. II. Non-specific serologic reactions, Am. J. M. Sc. 212: 716, 1946. CrossrefMedlineGoogle Scholar12. HarrisHarris STN: Serologic response to streptococcal hemolysin and hyaluronidase in streptococcal and rheumatic infection, J. Clin. Invest., in press. Google Scholar13. Harris TN: Studies in the relation of the hemolytic streptococcus to rheumatic fever. III. Complement fixation with streptococcal nucleoproteins in sera of patients with rheumatic fever and others, J. Exper. Med. 87: 57, 1948. CrossrefMedlineGoogle Scholar14. HarrisHarris STN: The measurement of neutralizing antibodies to streptococcal hyaluronidase by a turbidimetric method, J. Immunol. 63: 233, 1949. MedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Philadelphia, Pennsylvania*Received for publication August 9, 1949.From The Children's Hospital of Philadelphia (Department of Pediatrics, School of Medicine, University of Pennsylvania), The Children's Seashore House for Invalid Children, Atlantic City, N. J., the Philadelphia General Hospital and the Arthritis Section of the Hospital of the University of Pennsylvania.This study was supported by grants from the Life Insurance Medical Research Fund and the Helen Hay Whitney Foundation. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byAllergic Renal DiseasesBIBLIOGRAPHYSerological Agglutination and Precipitin Mechanisms in Rheumatoid ArthritisBesondere Serologische ReaktionenAetiology and pathogenesis of rheumatoid arthritisAnti-Streptococcal-Hyaluronidase III.Anti-Streptoeoccal-Hyaluronidase IV.Allergische KrankheitenRHEUMATISM AND ARTHRITIS REVIEW OF AMERICAN AND ENGLISH LITERATURE OF RECENT YEARS (TENTH RHEUMATISM REVIEW)* Part IIWILLIAM D. ROBINSON, M.D., F.A.C.P., EDWARD W. BOLAND, M.D., F.A.C.P., JOSEPH J. BUNIM, M.D., F.A.C.P., DARRELL C. CRAIN, M.D., F.A.C.P., EPHRAIM P. ENGLEMAN, M.D., F.A.C.P., WALLACE GRAHAM, M.D., F.R.C.P. (C), L. MAXWELL LOCKIE, M.D., F.A.C.P., MAX M. MONTGOMERY, M.D., F.A.C.P., CHARLES RAGAN, M.D., F.A.C.P., MARIAN W. ROPES, M.D., F.A.C.P., EDWARD F. ROSENBERG, M.D., F.A.C.P., CHARLEY J. SMYTH, M.D.Bibliography*Mucolytic enzyme systemsImmunbiologische Vorgänge bei der akuten diffusen Glomerulo-NephritisHyaluronidase Spread and the Effect of Salicylates in Rheumatic Fever 1 May 1950Volume 32, Issue 5Page: 917-922KeywordsAttentionChildrenEnzymesGlomerulonephritisHospital medicinePediatricsResearch fundingRheumatic feverRheumatoid arthritisStreptococcal infections Issue Published: 1 May 1950 PDF downloadLoading ...