HETEROPHILE ANTIBODY REACTION IN INFECTIOUS MONONUCLEOSIS
Authors: Robert E. Kaufman
Journal: Annals of Internal Medicine (1944)

Article1 August 1944HETEROPHILE ANTIBODY REACTION IN INFECTIOUS MONONUCLEOSISROBERT E. KAUFMANROBERT E. KAUFMANSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-21-2-230 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe sheep cell agglutination test or heterophile antibody reaction, as it is also called, is a laboratory procedure of considerable value in clinical medicine. In this country one frequently speaks alternately of the Paul-Bunnell test; and in Europe it is often referred to as the Hanganutziu-Deicher reaction. In 1911 Forssman1recognized the nonspecificity of certain antigen-antibody reactions. The terms "heterogenetic," "heterophilic," or "heterophile" are applied to those antibodies that react with an antigen (sheep erythrocytes) which seemingly had nothing to do with their development. 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