tbuckley/cabot-search huggingface dataset:
PERIRENAL LYMPHANGIOMA CAUSING HYPERTENSION
Authors: J E PULASKI
Journal: Annals of Internal Medicine (1950)

Case Reports1 July 1950PERIRENAL LYMPHANGIOMA CAUSING HYPERTENSIONJOHN E. PULASKI, M.D.JOHN E. PULASKI, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-33-1-234 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe literature on the subject of perirenal lymphangioma is extremely scanty. An excellent article with review of the subject has been presented by Kretschmer.2 Peripelvic cysts, which are large lymphatic cysts of the kidney, have been described very thoroughly by Henthorne,10 and recently in an article by Scholl.9 The purpose of this presentation is to report another case of unilateral pyelonephritis resulting from compression of the left renal pedicle by a cavernous lymphangioma . . . with subsequent development of severe hypertension. Death resulted from an intracerebral hemorrhage.CASE REPORTA 47 year old colored male janitor was first admitted...Bibliography1. Kreutzman HA: Hypertension associated with solitary renal cyst: report of two cases, J. Urol. 57: 467-472, 1947. CrossrefMedlineGoogle Scholar2. KretschmerHibbs HLWG: Retroperitoneal perirenal lymphangioma, Arch. Surg. 29: 113-125, 1934. CrossrefGoogle Scholar3. MurbackLewinsonDeibert CFEFGA: Lymphangioma of the abdomen, Am. J. Surg. 68: 391-397, 1945. CrossrefGoogle Scholar4. Smithwick R: Medical progress: surgery of the autonomic nervous system, New England J. Med., May 1, 1947. CrossrefGoogle Scholar5. Goldblatt H: Studies on experimental hypertension, J. Exper. Med. 59: 347-380, 1934. CrossrefMedlineGoogle Scholar6. AshworthHaynes CTDM: Lesions in the elastic arteries associated with hypertension, Am. J. Path. 195-209, 1948. MedlineGoogle Scholar7. Wattenberg CA: Hypertension and the kidney, Ann. Int. Med. 25: 734-741, 1946. LinkGoogle Scholar8. BarkerWalters NWW: Hypertension and chronic atrophic pyelonephritis, J. A. M. A. 115: 912, 1940. CrossrefGoogle Scholar9. Scholl AJ: Peripelvic lymphatic cysts of the kidney, J. A. M. A. 136: 4-7, 1948. CrossrefMedlineGoogle Scholar10. Henthorne JC: Peripelvic lymphatic cysts of the kidney, Am. J. Clin. Path. 8: 28-38, 1938. CrossrefGoogle Scholar11. Scheinker JM: Changes in the cerebral veins in hypertensive brain disease and their relation to cerebral hemorrhage, Arch. Neurol. and Psychiat. 54: 395, 1945. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: JOHN E. PULASKI, M.D.Affiliations: Washington, D. C.*Received for publication April 8, 1948. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byUnilateral Renal Lymphangiectasia: Imaging Appearance on Sonography, CT and MRI 1 July 1950Volume 33, Issue 1Page: 234-243KeywordsHemorrhageHypertensionKidneysPyelonephritis ePublished: 1 December 2008 Issue Published: 1 July 1950 PDF downloadLoading ...
Transplantation of Polyoma Virus-induced Tumors in Mice
Authors: Hans Olof Sjögren, Ingegerd Hellström, George Klein
Journal: Cancer Research (1961)

Summary  Fifty-two polyoma-induced primary mouse tumors were tested for transplantability in isologous recipients. Thirty-five tumors grew progressively in the subcutaneous tissue, and several lines have been established in serial transplantation. The remaining tumors did not grow out at all upon transfer.  Eleven among the transplantable tumors have been tested by inoculating known numbers of cells to the following three groups of adult isologous recipients: ( a ) untreated mice, maintained at a separate, polyoma-free colony, ( b ) mice preimmunized as adults against polyoma virus containing supernatant fluids from infected mouse embryo tissue cultures, and ( c ) mice pretreated with heavily irradiated cells of the same tumor. There was a clear and consistent difference between groups  a  and  b  for ten of eleven tumors, indicating a state of resistance against transplantation of the established polyoma tumors in the virus-immunized group. With the exception of two out of nine experiments, there was no evidence of resistance in group  c , pretreated with irradiated tumor cells. Serum of virus-immunized mice had a certain inhibiting effect on viable polyoma tumor cells upon incubation  in vitro  with one of four tumors. The possible implications of these findings have been discussed.
Britain on the Couch: Treating a Low Serotonin Society, by Oliver James
Authors: S. Wessely
Journal: BMJ (1998)

Oliver James

Century, £16.99, pp 402

ISBN 0 7126 7885 9

According to the Spectator , we are more depressed than ever. The reasons are the breakdown of the family and the increased pace and competition of life. A professor of medicine publishes a paper linking an increase in nervous ills with other unwelcome features of modern life. Now psychologist and media pundit Oliver James tells us much the same—we are richer than ever before, and also unhappier.

Yet the Spectator column was dated 1894, and the professor was writing in 1895. Perhaps we always believe in a past when people were satisfied with their lot. But before we dismiss it all as fin de siecle angst, this time statistics back up the argument. The WHO has announced that depressive illness, currently …
Abstract 19139: Impact of Medical Study Publication on Cholesterol Medication Prescriptions
Authors: William B Borden, Haizhen Lin, Tara F Bishop, Alvin I Mushlin, Kosali Simon
Journal: Circulation (2014)

Introduction: The challenges of translating research findings into practice have been well demonstrated, though some high impact studies do change care delivery. It is unknown whether such trials have spillover effects onto similar but unrelated medications. Hypothesis: Cholesterol trial findings change prescriptions for both trial drugs and statins in the direction of the results, even if statins were not directly studied. Methods: The Symphony Health Solutions’ PHAST Prescription Monthly database provided retail prescriptions from 2007 to 2013. We selected 5 cholesterol trials that were all published in the New England Journal of Medicine. The trials [main drug(s) studied, result] were: ENHANCE [simvastatin/ezetimibe, negative], JUPITER [rosuvastatin, positive], ARBITER 6 HALTS [niacin, positive; ezetimibe, negative], ACCORD LIPID [fenofibrate, negative], AIM HIGH [niacin, negative]. For each trial, we performed a difference-in-differences analysis for both the main drug(s) studied and statins using anti-hypertensive drugs as the control, comparing the 1 and 12 month prescription averages after to an average of the 12 months before the trial. Results: The 12-month average study drug monthly prescriptions changed in the direction expected from the trial results for all (p&lt;0.01), except niacin post ARBITER trial. After ENHANCE, simvastatin/ezetimbe changed -533,490 (95% CI -655,008, -411,976); after JUPITER, rosuvastatin changed 337,328 (278,722, 395,934); after ARBITER, niacin changed 1,335 (-17,625, 20,294) and ezetimibe changed -185,587 (-222,697, -148,147); after ACCORD, fenofibrate changed -263,522 (-316,805, -210,238); after AIM HIGH, niacin changed -154,460 (-182,760, -126,160). Over 50% of the year change occurred in the first month after each trial, except niacin post ARBITER. The trend of increasing statin prescriptions was unperturbed by the trial results. Conclusions: Individual cholesterol trial drug prescriptions changed substantially and as expected after trial results, with the majority of the change occurring immediately after trial publication. There was no evidence for detrimental spillover effects on statin prescriptions. These results suggest that the uptake of these trial findings was appropriate.
Genetic association studies between the MyD88 adaptor pathway SNPs and the development of tuberculosis
Authors: Foteini Malli, Vicky Mollaki, Angela Koutsokera, Irene Gerogianni, Konstantinos Gourgoulianis, George Vassilopoulos, Zoe Daniil
Journal: European Respiratory Journal (2011)

Background: Tuberculosis (TB) is characterized by the formation of granulomas. Myeloid Differentiation factor (MyD)88 is the common adaptor molecule that communicates the Toll-like receptor (TLR) engagement on the cell surface to intracellular events. TLRs are extracellular receptors that recognize specific molecular patterns found in a broad range of microbial pathogens, triggering inflammatory responses. There is evidence that MyD88-/- animals fail to form granulomas, while animal studies indicate that MyD88 signalling pathway is crucial for the control of M.Tuberculosis infection.

Objectives: We hypothesize that a defect in MyD88 pathway results in increased susceptibility of M. tuberculosis infection through reduced immune response following the recognition of the microorganism by TLR proteins. To this end we analyzed SNPs in the MyD88 gene.

Methods: 93 TB patients with culture-proven or smear-positive microscopy active TB and 92 controls were analyzed for the following SNPs; MyD88 - 938C>A and MyD88 1944C>G.

Results: . The MyD88-938CA genotype is associated with an increased risk of developing TB with an Odds Ratio (OR) of 2.62 (95% Confidence Intervals [CIs] 1.31-5.22, p=0.006) while the MyD881944CC genotype is associated with an increased risk of developing TB (OR: 4.83 (95% CIs: 1.86-12.52, p=0.001).

Conclusions: The results indicate that the MyD88-938CA and the MyD881944CC genotypes may be associated with increased M.Tuberculosis infection susceptibility. Since 1/3 of the worlds population has been in contact with M. tuberculosis but only 10% of them will develop an active infection, our findings provide important insights regarding tuberculosis development.
Sickle cell disease
Authors: Gregory J. Kato, Frédéric B. Piel, Clarice D. Reid, Marilyn H. Gaston, Kwaku Ohene-Frempong, Lakshmanan Krishnamurti, Wally R. Smith, Julie A. Panepinto, David J. Weatherall, Fernando F. Costa, Elliott P. Vichinsky
Journal: Nature Reviews Disease Primers (2018)
Something to celebrate: As I recall
Authors: D. Morrell
Journal: BMJ (1998)

At the end of half a century of general practice in the NHS it is interesting to reflect on the enormous changes that have occurred in this branch of medicine. My qualifications for doing so are that I entered medical school in 1947, graduated in 1952, entered general practice in 1957, and retired in 1993. I was active in the College of General Practitioners from its earliest years and in academic general practice from its inception. I have worked with most of the leaders in general practice over this time. From this very personal perspective I attempt to review the evolution of general practice in the NHS.

#### Summary points

The NHS introduced free access to primary care services to the entire population, and in operating the new service general practitioners and their patients were confused about their roles

Research in the first two decades of the NHS clarified the diagnostic methods appropriate in managing illness in primary care, and the training and organisation needed to fulfil this role

After the family doctor charter in 1966, research and training in general practice and the reorganisation of primary care flourished

The changes introduced in 1990, compounded by cultural changes in the population and the profession, now challenge the role of the general practitioner as a provider of personal and continuing primary medical care

I have no personal experience of general practice before or immediately after the introduction of the NHS. To get a feel for the benefits and difficulties that the NHS brought to the lives of general practitioners it is necessary to turn to anecdotes from doctors living through that time, leading articles and letters in medical journals, and a limited number of biographies.

The one great financial benefit that the service conferred on many general practitioners was to relieve them from the …
Abstract 1638: Effect of the phytochemical crinumaquine on prostate mesenchymal type cells
Authors: Kristo Marvyin, Run-hui Liu, Huizi Jin, Yaping Hua, Yi Qu, Xisong Ke, Karl-Henning Kalland, Wei-dong Zhang, Anne Margrete Oyan
Journal: Cancer Research (2014)

Abstract In a prostate carcinogenesis cell culture model benign EP156T prostate epithelial cells underwent epithelial to mesenchymal transition (EMT), and a series of progeny EPT mesenchymal type cells accumulated malignant features in a stepwise fashion. Through the screening of phytochemicals using this model, we have found that crinumaquine inhibited proliferation of mesenchymal type EPT1 and EPT2 cells more efficiently than the compound inhibited epithelial type EP156T cells. Genome-wide gene expression analysis revealed a pattern where crinumaquine induced patterns associated with cell cycle arrest at both G1-S and G2-M phase checkpoints and strong up-regulation of genes involved in DNA repair and CDKN1A and CDKN1C and chromatin rearrangement. Differentially expressed genes were uploaded to the Connectivity Map tools (The Broad Institute, MA, USA) and the highest score was associated with histone deacetylase inhibitors. ChemMap analysis based on its chemical structure indicated that crinumaquine targets ER-β and cyclines. Crinumaquine was also found to induce up-regulation of CDH1 and other genes associated with an incomplete mesenchymal to epithelial transition (MET) of EPT1 and EPT2 cells, and this was associated with increased apoptosis markers in gene expression and Western blot analyses. Due to the selective inhibition of mesenchymal type and more malignant cells of the model, crinumaquine will be further explored concerning its anti-cancer leading compound potential. Citation Format: Kristo Marvyin, Run-hui Liu, Huizi Jin, Yaping Hua, Yi Qu, Xisong Ke, Karl-Henning Kalland, Wei-dong Zhang, Anne Margrete Oyan. Effect of the phytochemical crinumaquine on prostate mesenchymal type cells. [abstract]. In: Proceedings of the 105th Annual Meeting of the American Association for Cancer Research; 2014 Apr 5-9; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2014;74(19 Suppl):Abstract nr 1638. doi:10.1158/1538-7445.AM2014-1638
Rapid complete response of metastatic melanoma in a patient undergoing ipilimumab immunotherapy in the setting of active ulcerative colitis
Authors: A Doran Bostwick, April K Salama, Brent A Hanks
Journal: Journal for ImmunoTherapy of Cancer (2015)

While blockade of the cytotoxic T-lymphocyte antigen-4 (CTLA-4) T cell regulatory receptor has become a commonly utilized strategy in the management of advanced melanoma, many questions remain regarding the use of this agent in patient populations with autoimmune disease. We present a case involving the treatment of a patient with stage IV melanoma and ulcerative colitis (UC) with anti-CTLA-4 antibody immunotherapy. Upon initial treatment, the patient developed grade III colitis requiring tumor necrosis factor-alpha (TNF-α) blocking antibody therapy, however re-treatment with anti-CTLA-4 antibody following a total colectomy resulted in a rapid complete response accompanied by the development of a tracheobronchitis, a previously described extra-intestinal manifestation of UC. This case contributes to the evolving literature on the use of checkpoint inhibitors in patients also suffering from autoimmune disease, supports future clinical trials investigating the use of these agents in patients with autoimmune diseases, and suggests that an understanding of the specific molecular pathways involved in a patient's autoimmune pathology may provide insight into the development of more effective novel combinatorial immunotherapeutic strategies.
Infectious diseases in Rome during the Millennium Year
Authors: P Giorgi Rossi, M. Sangalli, A. Faustini, F Forastiere, C. A. Perucci
Journal: Eurosurveillance (2003)

During 2000, the millennium year, 26 million people visited Rome. An improved surveillance system for infectious diseases, especially for foodborne disease outbreaks (FBDO), meningitis, and legionnaires' disease was introduced in 1997. This rapid alert network links public health services with the principal sources of diagnosis and laboratory based surveillance. For travel related legionnaires' disease, international surveillance was implemented. Specific control measures for FBDOs were adopted. No increase in the overall incidence of these diseases was observed, and no atypical pathogens in FBDOs or meningitis were isolated in 2000 relating to 1998-99. Cases of legionnaires' disease and FBDOs involving foreign tourists increased (10/4 and 7/2 observed/expected respectively). Three out of six FBDOs involving pilgrims occurred in religious guesthouses. While an increase in cases of legionnaires' disease and FBDOs among foreign tourists was observed by the surveillance system, the millennium year did not influence the epidemiology of infectious diseases in the residential population of Lazio.
Response 2 to pharmacogenetic screening to prevent carbamazepine-induced toxic epidermal necrolysis and Stevens-Johnson syndrome: a critical appraisal
Authors: A. Alfirevic, M. McCormack, M. Pirmohamed, G.L. Cavalleri
Journal: British Journal of Dermatology (2011)

We welcome the appraisal by Wu and Reynolds1 and are grateful for the opportunity to respond. The issues raised can be summarized as follows: ... An accurate phenotype is critical to successful genetic mapping. In this context, we applied (across all patients) strict inclusion criteria2 for each of the three clinical manifestations of carbamazepine hypersensitivity. Further, we are confident the adverse drug reactions were specific to carbamazepine as (i) many of our patients were on monotherapy at the time of the reaction, (ii) hypersensitivity typically occurred within 8 weeks of exposure to carbamazepine and (iii) the reaction typically resolved on withdrawal of carbamazepine and, in cases of carbamazepine rechallenge, often recurred. Patients on polytherapy were removed if there was any doubt regarding the causal drug. Comorbidity was also considered and relevant investigations undertaken to exclude alternative causes. Most of the patients had been heavily phenotyped for previous publications.3–7 Furthermore, many of the patients in the Liverpool dataset had previously had positive cytotoxicity assays and lymphocyte transformation tests.8–10
Study Concludes That Moderate PSA Levels Are Unrelated to Prostate Cancer Outcomes
Authors: Brian Vastag
Journal: JAMA (2002)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Safety and feasibility of laparoscopic sigmoid colon and rectal cancer surgery in patients with previous vertical abdominal laparotomy
Authors: Mustafa Haksal, Yasar Ozdenkaya, Ali Emre Atici, Nuri Okkabaz, Nihat Aksakal, Ayhan Erdemir, Osman Civil, Mustafa Oncel
Journal: International Journal of Surgery (2015)
Medical education in the United States
Authors: R H Ebert
Journal: JAMA (1980)

in this country, and that makes it impossible to have a discussion of medical education without quoting the  Report of 1910 and referring to the Flexner model. The  model is that of a medical school totally integrated into the university, and so powerful has it become that the reality of what exists today and, indeed, what has existed for a very long time, is often obscured by its influence. Because medical schools and medical centers, according to the interpreters of Flexner, are supposed to be integral parts of universities, they are described as being so, even though it should be apparent to the most casual observer that the relationship of the medical school medical center to the university bears no resemblance to that of any other school, faculty, or division in it. A dominant theme of this essay will center on the tension that arises from the often artificial attempts to give this belief credence by describing non university activities as being university ones. Medical education is a continuum which begins in college, progresses through medical school, and ends with the postgraduate years of internship and residency training. These three phases?college, medical school, and residency?are convenient divisions of the educational process, since the conclusion of each is marked by an academic degree or certification. But there is also another way of describing the phases?as a university phase and a non-university or hospital phase. This division will be viewed with disfavor by those who adhere to the  model, yet it may be a more accurate description of the educational environment than are the traditional distinctions based on the granting of degrees. The university phase comprises the collegiate or premedical portion of the education of the physician plus the so-called preclinical portion of medical school. The hospital phase includes the clinical clerkship during the last two years of medical school together with internship and residency training. In whatever way the education of the physician is viewed, it is remarkable how little change has taken place in the fundamental organization of medical education over the past half-century. The most significant modification has been in the non-university or hospital phase of the educational process, and this change has occurred predominantly in the internship-residency period of hospital training.
Hippocrates’ Contributions to Dermatology Revealed
Authors: Mohammed Alsaidan, Brian J. Simmons, Fleta N. Bray, Leyre A. Falto-Aizpurua, Robert Denison Griffith, Keyvan Nouri
Journal: JAMA Dermatology (2015)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Dermatology HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Dermatology journal