tbuckley/cabot-search huggingface dataset:
A VALUABLE SIGN IN THE DIAGNOSIS OF FUNCTIONAL AORTIC INSUFFICIENCY
Authors: Samuel A. Loewenberg
Journal: Annals of Internal Medicine (1940)

Article1 December 1940A VALUABLE SIGN IN THE DIAGNOSIS OF FUNCTIONAL AORTIC INSUFFICIENCYSAMUEL A. LOEWENBERG, M.D., F.A.C.P.SAMUEL A. LOEWENBERG, M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-14-6-991 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptGarvin1 reawakened interest in the subject of functional aortic insufficiency by citing 14 cases that came to autopsy. An analysis of his cases reveals that he included in this category patients who had a diastolic aortic murmur during life, but who showed no crippling of the aortic valves at autopsy. Among this group, the majority presented definite arteriosclerotic changes and several had a double aortic murmur.Of the 14 cases reported all but three (cases 4, 5, and 12) had high diastolic pressures: thus, case 2 had a diastolic pressure of 110; case 3, 110; case 6, 96; case 7,...Bibliography1. GARVIN CF: Functional aortic insufficiency, ANN. INT. MED., 1940, xiii, 1799-1804. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Philadelphia, Pennsylvania*Received for publication June 18, 1940. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byMiscellaneous Murmurs and FindingsREFERENCESFunctional Aortic Insufficiency — A Feature of Renal FailureAortic regurgitation in the elderlyComparison of Blood Pressures in the Arms and LegsTransient “0” diastolic brachial pressure (indirect), associated with normal or elevated popliteal pressure, tachycardia, and nervous tensionMeasurements of arterial blood pressure in the arm and leg: Comparison of sphygmomanometric and direct intra-arterial pressures, with special attention to their relationship in aortic regurgitationAortic regurgitation caused by dilatation of the aortic orifice and associated with a characteristic valvular lesion 1 December 1940Volume 14, Issue 6Page: 991-992KeywordsAortic valveAutopsyBlood pressure ePublished: 1 December 2008 Issue Published: 1 December 1940 PDF downloadLoading ...
THE DETECTION OF SUBCLINICAL SCURVY OR VITAMIN C DEFICIENCY
Authors: James F. Rinehart, Louis D. Greenberg
Journal: Annals of Internal Medicine (1942)

ExcerptClinically classical scurvy is uncommon although cases are still encountered occasionally in infants and less frequently in adults. Is there a lesser degree of vitamin C deficiency which undermines health but is not manifest as scurvy? Nutrition is one factor over which we have some control. Optimal health is, of course, the goal of medicine and it assumes particular importance in times of national stress. If the vitamin C nutrition is suboptimal in any considerable portion of our population it is important that we should know it and define methods for its recognition.Considered from a biochemical standpoint there is...
Anti-tumor effects of chemotherapeutics are enhanced by genistein in pancreatic cancer.
Authors: S. Banerjee, Z. Wang, Pj Chiao, Fh Sarkar
Journal: Cancer Research (2006)

Proc Amer Assoc Cancer Res, Volume 47, 2006

5412 

Purpose: Currently standard therapies for pancreatic cancer consist of administering cytotoxic chemotherapeutic agents or irradiation treatment alone, or in combination. Unfortunately the therapeutic benefit remains modest due to high degree of inherent and acquired chemoresistance. We recently reported that genistein augments pancreatic tumor sensitivity to gemcitabine due to the inactivation of Akt and NF-κB signalling (Cancer Res. 2005; 65:9064-72). In order to further dissect the molecular pathway, we used MDA Panc-28 and stably transfected MDA Panc-28/IκBαM [phosphorylation defective IκBα (S32, 36A) that blocks NF-κB activation] pancreatic cancer cells exposed to genistein with and without gemcitabine, cisplatin or oxaliplatin. Method: MDA Panc-28 and MDA Panc-28/IκBαM cells were cultured in complete DMEM media with and without genistein (0-100μM) for 72 hrs for initial studies. Subsequently chemosensitivity towards three drugs- gemcitabine, cisplatin and oxaliplatin was also assessed in vitro using MTT, and apoptosis was assessed by quantifying cytoplasmic histone-DNA fragments using Cell Death Detection ELISA kit upon pretreatment with 25μM genistein (48 hrs) followed by gemcitabine, cisplatin or oxaliplatin (72 hrs). The molecular mechanism for enhanced chemosensitivity was investigated by performing Western immunoblot for pAkt, Bcl-2, Bcl-xL, and PARP. Additionally, gel shift assay was performed to elucidate the role of NF-κB transcription factor in suppressing apoptosis and attenuating the effect of chemotherapeutic agents by genistein. Results: The MDA Panc-28/IκBαM cells without NF-κB expression was found relatively more sensitive to genistein compared to parental MDA Panc-28 cells.Genistein pretreatment also significantly enhanced the anti-proliferative and pro-apoptotic effect of gemcitabine, cisplatin and oxaliplatin in NF-κB null cells relative to untreated control and the parental MDA Panc-28 cells. Several NF-κB downstream target molecules such as Bcl-xL, Bcl-2 and cyclin D1, survivin and MMP-9 were differentially affected by genistein pretreatment and combination treatments, which appears to be due to down regulation of NF-κB activity. Conclusion: Our results strongly suggest that chemosensitization of human pancreatic cancer cells is due to inhibition of NF-κB and Akt signaling, and thus it could form the basis for rational drug designing or utilization for the treatment of pancreatic tumors with better outcome.
Pityriasis lichenoides-like mycosis fungoides in children
Authors: J-W. Ko, J-Y. Seong, K-S. Suh, S-T. Kim
Journal: British Journal of Dermatology (2000)

Journal Article Pityriasis lichenoides‐like mycosis fungoides in children Get access J‐W. Ko, J‐W. Ko Department of Dermatology, Kosin Medical Center, 34 Amnam‐Dong, Suh‐ku, Pusan 602‐702, South Korea Search for other works by this author on: Oxford Academic Google Scholar J‐Y. Seong, J‐Y. Seong Department of Dermatology, Kosin Medical Center, 34 Amnam‐Dong, Suh‐ku, Pusan 602‐702, South Korea Search for other works by this author on: Oxford Academic Google Scholar K‐S. Suh, K‐S. Suh Department of Dermatology, Kosin Medical Center, 34 Amnam‐Dong, Suh‐ku, Pusan 602‐702, South Korea Kee‐Suck Suh. E‐mail: ksderm98@unitel.co.kr Search for other works by this author on: Oxford Academic Google Scholar S‐T. Kim S‐T. Kim Department of Dermatology, Kosin Medical Center, 34 Amnam‐Dong, Suh‐ku, Pusan 602‐702, South Korea Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 142, Issue 2, 1 February 2000, Pages 347–352, https://doi.org/10.1046/j.1365-2133.2000.03307.x Published: 01 February 2000
Neonatal examination and screening trial (NEST): a randomised, controlled, switchback trial of alternative policies for low risk infants Commentary: "Switchback" allocation---dangerous bends ahead!
Authors: C. M A Glazener, C. R Ramsay, M. K Campbell, P. Booth, P. Duffty, D. J Lloyd, A. McDonald, J A. Reid, J. J Deeks
Journal: BMJ (1999)

<h3>Abstract</h3> <b>Objective:</b> To evaluate the effectiveness of one rather than two hospital neonatal examinations in detection of abnormalities. <b>Design:</b> Randomised controlled switchback trial. <b>Setting:</b> Postnatal wards in a teaching hospital in north east Scotland. <b>Participants:</b> All infants delivered at the hospital between March 1993 and February 1995. <b>Intervention:</b> A policy of one neonatal screening examination compared with a policy of two. <b>Main outcome measures:</b> Congenital conditions diagnosed in hospital; results of community health assessments at 8 weeks and 8 months; outpatient referrals; inpatient admissions; use of general practioner services; focused analysis of outcomes for suspected hip and heart abnormalities. <b>Results:</b> 4835 babies were allocated to receive one screening examination (one screen policy) and 4877 to receive two (two screen policy). More congenital conditions were suspected at discharge among babies examined twice (9.9 <i>v</i> 8.3 diagnoses per 100 babies; 95% confidence interval for difference 0.3 to 2.7). There was no overall significant difference between the groups in use of community, outpatient, or inpatient resources or in health care received. Although more babies who were examined twice attended orthopaedic outpatient clinics (340 (7%) <i>v</i> 289(6%)), particularly for suspected congenital dislocation of the hip (176 (3.6/100 babies) <i>v</i> 137 (2.8/100 babies); difference −0.8; −1.5 to 0.1), there was no significant difference in the number of babies who required active management (12 (0.2%) <i>v</i> 15 (0.3%)). <b>Conclusions:</b> Despite more suspected abnormalities, there was no evidence of net health gain from a policy of two hospital neonatal examinations. Adoption of a single examination policy would save resources both during the postnatal hospital stay and through fewer outpatient consultations. <h3>Key messages</h3> Neonatal screening in hospital after delivery can be safely carried out once rather than twice Introduction of this policy would save hospital resources, both during the postnatal period and subsequently through fewer outpatient consultations Later surveillance is an essential complement to hospital screening (whether performed once or twice) to detect abnormalities missed in hospital and conditions which develop after discharge
An investigation of peak cough flow (PCF) rates in patients post lung resection
Authors: Kate Devenney, Ciara Griffin, Sarah Mitchell, Emer Guinan, Ronan Ryan
Journal: European Respiratory Journal (2013)

Introduction:  Postoperative patients have an impaired airway clearance mechanism and the amount of mucus they produce in the post operative period is often increased (Smith and Ellis 2000). Peak cough flow (PCF) rates <160L/min are considered inadequate to facilitate airway clearance (Bach 1996).

Aim: To investigate whether inadequate PCF in patients following lung resective surgery was predictive of hospital length of stay (LOS), high dependency unit (HDU) bed days or days requiring non-invasive ventilation (NIV).

Methods:  PCF measurements were obtained preoperatively and day 1 – 3 postoperatively in 17 patients following lung resective surgery.

Descriptive statistic and ANOVA analysis was performed using SPSS, results are presented as mean +/- standard deviation.

Results: 17 patients met the inclusion criteria and consented for participation, 3 did not complete post operative testing, therefore results are presented for 14 participants (male 4; age 65.6 y +/-7.5; FEV1/FVC 70.4 %+/- 9.1; HDU LOS 2.1 d +/- 1.2; hospital LOS 11.6 d +/-5.2).

There was a reduction in PCF immediately following surgery (PreOp PCF 268+/- 127; D1PCF 118 +/-55; D2PCF 130 +/- 62; D3PCF 139 +/- 66). There was no correlation between post operative pain scores and PCF values. When differentiated into groups using <160L/min as a measure of ineffective cough, no difference was ascertained in requirement for NIV (n=2), HDU or hospital LOS at any time point.

Conclusion: PCF is a simple easy tool to assess cough efficiency. Its use in this patient group is novel, however the figure of >160L/min unit is not a useful tool for prediction of NIV requirement, HDU or hospital LOS.
Religion, Spirituality, and the Intensive Care Unit
Authors: Tracy A. Balboni, Michael J. Balboni, George Fitchett
Journal: JAMA Internal Medicine (2015)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Internal Medicine HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Internal Medicine journal
International differences in clinical characteristics, management, and outcomes in acute heart failure patients: better short‐term outcomes in patients enrolled in Eastern Europe and Russia in the <scp>PROTECT</scp> trial
Authors: Robert J. Mentz, Gad Cotter, John G.F. Cleland, Susanna R. Stevens, Karen Chiswell, Beth A. Davison, John R. Teerlink, Marco Metra, Adriaan A. Voors, Liliana Grinfeld, Mikhail Ruda, Viacheslav Mareev, Chaim Lotan, Daniel M. Bloomfield, Mona Fiuzat, Michael M. Givertz, Piotr Ponikowski, Barry M. Massie, Christopher M. O'Connor
Journal: European Journal of Heart Failure (2014)
Abstract 5849: Protein Phosphatase 2A Inhibition Prevents NO-induced Caspase-3 Activation and Apoptosis
Authors: Yong Xia, Li Lin
Journal: Circulation (2009)

Nitric oxide (NO), depending on its concentrations, can be either beneficial or detrimental in cardiovascular injury. For example, physiological levels of NO generated by eNOS protect postischemic hearts; whereas excessive NO from iNOS damage cells in heart failure. High levels of NO have been shown to activate caspase-3 leading to apoptosis. But the underlying mechanism is not fully understood. Here we identify protein phosphatase 2A (PP2A) as a crucial regulator in NO-induced caspase-3 activation and apoptosis. To explore the mechanism of NO-induced apoptosis, the HEK 293 cells were treated with NO donor SNAP. The concentrations of NO released by SNAP in the medium were monitored by the electrochemical detector. NO (0.1–10 μM) dose-dependently induced caspase-3 activation as evidenced by the increases of caspase-3 cleavage. Okadaic acid (100 nM) prevented caspase-3 activation in NO-treated cells, suggesting that PP2A was involved. Indeed, PP2A knockdown with siRNA largely abolished NO-induced caspase-3 ...
Abstract 15702: Neutrophil Gelatinase-associated Lipocalin (NGAL) Correlates With Impaired Renal Function In Patients With Advanced Heart Failure And Corrects After Ventricular Assist Device Placement
Authors: Katherine Pronschinske, Sylvia Qiu, Christina Wu, Tomoko Kato, Tuba Khawaja, Faisal Cheema, Hiroo Takayama, Yoshifumi Naka, Donna Mancini, P. Christian Schulze
Journal: Circulation (2011)

Introduction: Patients with advanced heart failure (HF) develop progressive renal dysfunction. Novel renal biomarkers such as neutrophil gelatinase-associated lipocalin (NGAL) might improve the pro...
Potentially modifiable risk factors for adverse pregnancy outcomes in women with psoriasis
Authors: G. Bandoli, D.L. Johnson, K.L. Jones, J. Lopez Jiminez, E. Salas, N. Mirrasoul, A.S. Van Voorhees, C.D. Chambers
Journal: British Journal of Dermatology (2010)

Data on pregnancy outcomes among women with psoriasis are lacking. However, there are several known comorbidities of psoriasis, including obesity, smoking and depression, each of which increases the risk for negative birth outcomes.To determine if pregnant women with psoriasis have an excess of potentially modifiable risk factors for adverse pregnancy outcomes.Prospectively collected data from the Organization of Teratology Information Specialists (OTIS) Autoimmune Diseases in Pregnancy Project were analysed to compare the prevalence of selected risk factors between 170 pregnant women with psoriasis and 158 nondiseased controls.Women with psoriasis were more likely to be overweight/obese prior to pregnancy (P < 0.0001), to smoke (P < 0.0001), or to have a diagnosis of depression (P = 0.03), and were less likely to have been taking preconceptional vitamin supplements (P = 0.004). After controlling for race/ethnicity and socioeconomic status, women with psoriasis were 2.37 (95% confidence interval 1.45-3.87) times more likely to be overweight/obese as women without psoriasis. Duration of disease, age at onset, measures of disease impact during pregnancy, or use of biologics in pregnancy were not significant predictors of overweight/obesity in the subset of psoriatic women.Pregnant women with psoriasis may be at increased risk for adverse pregnancy outcomes due to comorbidities or other health behaviours associated with the disease. These should be taken into consideration during clinical treatment of women with psoriasis who are in their childbearing years.
Genes Decoded for Malaria . . .
Authors: Joan Stephenson
Journal: JAMA (1998)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Abstract 1153: The Effect of Dietary Patterns on Estimated Coronary Heart Disease Risk: Results From the Dietary Approaches to Stop Hypertension Trial
Authors: Steven T Chen, Nisa M Maruthur, Lawrence J Appel
Journal: Circulation (2009)

Background In lifestyle intervention trials, the primary outcomes are typically risk factors, not clinical outcomes. In the Dietary Approaches to Stop Hypertension (DASH) trial, the DASH dietary pa...
Abstract 20: Carbohydrate Quality, Measured Using Multiple Carbohydrate Quality Metrics, is Negatively Associated with Risk of Type 2 Diabetes in US Women
Authors: Hala AlEssa, Shilpa Bhupathiraju, Vasanti Malik, Nicole Wedick, Hannia Campos, Bernard Rosner, Walter Willett, Frank B Hu
Journal: Circulation (2015)

Background: Carbohydrate quality may be an important determinant of type 2 diabetes (T2D), however, the relationships between various carbohydrate quality metrics and T2D risk have not been systematically investigated. Objective: To prospectively examine the association between carbohydrate, starch, fiber, and different combinations of these nutrients in relation to the risk of T2D in US women. Methods: We prospectively collected information on diet and lifestyle behaviors among 70,041 women from the Nurses Health Study every 2-4 years, after baseline in 1984. These participants were free of diagnosed cardiovascular disease, cancer, or diabetes at baseline. We used Cox proportional hazards regression models to assess the association between dietary factors of interest and incidence of T2D. Results: With 24 years of follow-up we ascertained 6,934 incident cases of T2D during 1,484, 213 person years of follow-up. After adjusting for age, lifestyle and dietary variables, total carbohydrate intake was not associated with T2D (RR=0.98, 95% CI: 0.89 - 1.08, p for trend=0.84), while starch was positively associated with T2D (RR=1.23, 95%CI: 1.12 - 1.35), p for trend &lt;0.0001), comparing the highest to lowest quintile. Total fiber (RR= 0.80, 95%CI: 0.72 - 0.89, p for trend &lt; 0.0001), cereal fiber (RR= 0.71, 95%CI: 0.65 - 0.78, p for trend &lt; 0.0001) and fruit fiber (RR= 0.80, 95%CI: 0.73 - 0.88, p for trend &lt; 0.0001) were all inversely associated with T2D, comparing extreme quintiles. . There was a borderline significant positive association between the ratio of carbohydrate to total fiber intake and risk of T2D (RR= 1.09, 95%CI: 1.00 - 1.20, p for trend = 0.039), and stronger positive associations between the ratios of carbohydrate to cereal fiber (RR= 1.28, 95%CI: 1.17 - 1.39, p for trend &lt; 0.0001), starch to total fiber (RR= 1.12, 95%CI: 1.02 - 1.23, p for trend = 0.030) and starch to cereal fiber (RR= 1.39, 95%CI: 1.27 - 1.53, p for trend &lt; 0.0001) with T2D, comparing extreme quintiles.. Conclusion: Diets with high starch, low fiber and high starch to cereal fiber ratio were associated with increased risk of T2D. Using the starch to cereal fiber ratio of the overall diet is a potentially useful way of assessing carbohydrate quality in relation to T2D.
Preventability of Hospital-Acquired Venous Thromboembolism
Authors: Elliott R. Haut, Brandyn D. Lau, Peggy S. Kraus, Deborah B. Hobson, Bhunesh Maheshwari, Peter J. Pronovost, Michael B. Streiff
Journal: JAMA Surgery (2015)

patients with complicated appendicitis, 173 (42.3%) were identified as having a serum sodium level of less than 135 mEq/L (to convert to millimoles per liter, multiply by 1.0).Longer hospital lengths of stay, deep surgical site infections, and return visits to the emergency department were more prevalent among patients with complicated appendicitis.Exploratory logistic regression analysis identified significant cut points and 4 independent predictors for complicated appendicitis, of which hyponatremia was found to have the strongest association with this outcome (Table 2).The C statistic or area under the curve of the model was 0.71.The Hosmer-Lemeshow goodness-of-fit statistic was P = .90.
Plastic surgeon settles discrimination case against NHS
Authors: Clare Dyer
Journal: BMJ (2001)

A plastic surgeon who accused her employers of sex discrimination and victimisation under the Race Relations Act settled for a six figure sum just hours before a tribunal was to start hearing her case. Judy Evans, a consultant at Derriford Hospital, Plymouth, accepted voluntary early retirement at the age of 50.

A confidentiality clause bars her from revealing the size of her settlement, but lawyers said the figure was likely to be more than …
Acute Leukemia Clinical Presentation
Authors: Gamal Abdul
Journal: Leukemia (2013)

The clinical presentation of acute leukemia results from infiltration of bone marrow or extramedullary sites by blasts. As a result, initial symptoms may be due to the presence of anemia, neutropenia, or thrombocytopenia. Patients generally present with nonspecific complaints including weakness, lethargy, fatigue, dyspnea, fever, weight loss, or bleed‐ ing. Blasts may also infiltrate organs or lymph nodes, resulting in hepatosplenomegaly or adenopathy. Bone marrow infiltration with blasts can result in bone pain. Mucosal bleeding, petechiae, ecchymosis, and fundal hemorrhages may occur as a result of thrombocytopenia.