Arthritis after Mycobacterium bovis Immunotherapy for Bladder Cancer
Authors: Thomas Ochsenkühn
Journal: Annals of Internal Medicine (1990)

Letters and Corrections1 June 1990Arthritis after Mycobacterium bovis Immunotherapy for Bladder CancerThomas Ochsenkühn, Matthias M. Weber, MD, Wolfgang H. Caselmann, MDThomas OchsenkühnSearch for more papers by this author, Matthias M. Weber, MDSearch for more papers by this author, Wolfgang H. Caselmann, MDSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-112-11-882_2 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the Editor: We read with interest the UCLA conference on molecular mimicry in HLA-B27-related arthritis (1). The authors propose that a cross-reactivity between HLA-B27 and antigenic bacterial components is the mechanism underlying the pathogenesis of synovial injury in reactive arthritis occurring after infection. Because of this mimicking effect, the immune response of the organism is directed against HLA-B27-positive cells. Similarly, shared antigenic determinants of a cartilage proteoglycan and Mycobacterium bovis, strain BCG (Calmette-Guerin bacillus), are responsible for adjuvant arthritis in rats.We report a case of BCG-induced severe arthritis in a man who received BCG immunotherapy for carcinoma of...References1. YuChooSchaack DSM. Molecular mimicry in HLA-B27-related arthritis. Ann Intern Med. 1989;111:581-91. LinkGoogle Scholar2. MoralesEidingerBruce ADA. Intracavitary BCG in the treatment of superficial bladder tumors. J Urol. 1976;116:80. CrossrefGoogle Scholar3. LammStogdillStogdillCrispen DVBR. Complications of BCG immunotherapy in 1278 patients with bladder cancer. J Urol. 1986;135:272-4. CrossrefMedlineGoogle Scholar4. PrescottJamesBusuttilHargreaveChisholmSmyth SKATGJ. HLA-DR expression by high grade superficial bladder cancer treated with BCG. Br J Urol. 1989;63:264-9. CrossrefMedlineGoogle Scholar5. TorisuMiyaharaShinoharaOhsatoSonozaki MTNKH. A new side effect of BCG immunotherapy-BCG induced arthritis in man. Cancer Immunol Immunother. 1978;5:77-83. CrossrefGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: University of Munich 8000 Munich Federal Republic of Germany PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByReactive arthritis induced by intravesical BCG therapy for bladder cancer: our clinical experience and systematic review of the literatureArthrites réactionnelles secondaires à la BCG-thérapie. Deux observations et revue de la littératureHSP Reactive T Cells are Anti-Inflammatory and Disease Suppressive in Arthritic DiseasesImmunoregulation of Autoimmune DiseasesReactive arthritis following BCG immunotherapy for urinary bladder carcinoma: a systematic reviewOsteoarticular side effects of BCG therapyComplications rhumatologiques de la BCG-thérapieHeat Shock Proteins in Rheumatoid ArthritisSpondiloartrite Acuta: Rara Complicanza in Corso di Terapia Endovescicale con BCGHeat-shock proteins and autoimmunity: Implications for multiple sclerosisArthritis after Bacillus Calmette-Guerin TherapyDavid W. Puett, MD, Howard A. Fuchs, MDImmunobiological preparationsImmunomodulating agentsHeat-Shock Proteins as Immunogenic Bacterial Antigens with the Potential to Induce and Regulate Autoimmune Arthritis 1 June 1990Volume 112, Issue 11Page: 882-882KeywordsAntigensArthritisBacille calmette guerinBladder cancerCancer immunotherapyCartilageCellsImmune responsePathogenesisReactive arthritis Issue Published: 1 June 1990 PDF DownloadLoading ...