HYPERTHERMIA CAUSED BY PENICILLIN-HEPARIN IN THE TREATMENT OF SUBACUTE BACTERIAL ENDOCARDITIS
Authors: K A CROCKETT, P S RHOADS
Journal: Annals of Internal Medicine (1948)

Case Reports1 February 1948HYPERTHERMIA CAUSED BY PENICILLIN-HEPARIN IN THE TREATMENT OF SUBACUTE BACTERIAL ENDOCARDITISKENNETH A. CROCKETT, M.D., PAUL S. RHOADS, M.D., F.A.C.P.KENNETH A. CROCKETT, M.D.Search for more papers by this author, PAUL S. RHOADS, M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-28-2-456 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptSince the advent of penicillin the literature contains numerous reports of cases and series of cases of subacute bacterial endocarditis successfully treated with penicillin alone or in combination with heparin. Many deleterious and even fatal results with heparin or heparin in combination with penicillin are on record. To these we wish to add a case report of excessive hyperthermia resulting from the administration of continuous intravenous penicillin to which a minimum amount of heparin had been added in order to obviate the frequent plugging of the intravenous needle. Rapidly accumulating evidence indicates that the use of heparin for any other...Bibliography1. LEVYMCKRILL LN: Results in the treatment of subacute bacterial endocarditis, Arch. Int. Med., 1946, lxxvii, 367-384. CrossrefGoogle Scholar2. HEILMAN DH, Mayo Clinic, Rochester, Minn., personal communication. Google Scholar3. DAWSONHUNTER MHTH: Treatment of subacute bacterial endocarditis with penicillin: second report, Ann. Int. Med., 1946, xxiv, 170-186. Google Scholar4. AVERYMAYERNELSON NLOBRC: Massive doses of penicillin in the treatment of subacute bacterial endocarditis, Ann. Int. Med., 1946, xxiv, 900-904. Google Scholar5. BEYERFLIPPINVERWEYWOODWARD KHHWFR: The effect of para-aminohippuric acid on the plasma concentration of penicillin in man, Jr. Am. Med. Assoc., 1944, lxxvi, 1007. CrossrefGoogle Scholar6. LOWEROSENBLARRWERBERKOZAK LPEAM: Prolonging action of penicillin by para-aminohippuric acid, Proc. Soc. Exper. Biol. and Med., 1945, lviii, 298-300. CrossrefGoogle Scholar7. RAMMELKAMPBRADLEY CHSE: Excretion of penicillin in man, Proc. Soc. Exper. Biol. and Med., 1943, liii, 30. CrossrefGoogle Scholar8. OKELLELLIOTT CCSD: Bacteriemia and oral sepsis with special reference to the etiology of subacute bacterial endocarditis, Lancet, 1935, ii, 869. CrossrefGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Chicago, Illinois*Received for publication October 28, 1946.From Wesley Memorial Hospital, Northwestern University Medical School. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byUnderstanding Drug-Induced Febrile ReactionsDrug fever induced by heparinSEVERE SPONTANEOUS HYPERSENSITIVITY TO HEPARIN*ALEXANDER GOTZ, M.D. 1 February 1948Volume 28, Issue 2Page: 456-460KeywordsEndocarditisHeparinHyperthermiaPenicillin ePublished: 1 December 2008 Issue Published: 1 February 1948 PDF downloadLoading ...