tbuckley/cabot-search huggingface dataset:
Vitamins in verse
Authors: T. Dalrymple
Journal: BMJ (2011)

Do we worry too much or too little about our health? I can never quite make up my mind, but it seems to me probable that there is an inverse anxiety law: those with most to worry about do so least, while those with least to worry about do so most.

To treat each meal as a medical procedure, however, is certainly to go too far in the direction of caution, even if a little bit of what we fancy does us harm. The comic poet and member of parliament (a combination of careers difficult to envisage today) A P Herbert, who was born in 1890 and died in 1971, satirised this tendency in his poem The Vitamins , published in 1930 in his collection …
Molecular Oncodiagnostics: Where We Are and Where We Need to Go
Authors: Edison T. Liu
Journal: Journal of Clinical Oncology (2003)

Article Tools EDITORIALS Article Tools OPTIONS & TOOLS Export Citation Track Citation Add To Favorites Rights & Permissions COMPANION ARTICLES No companion articles ARTICLE CITATION DOI: 10.1200/JCO.2003.01.137 Journal of Clinical Oncology - published online before print September 21, 2016 PMID: 12775728 Molecular Oncodiagnostics: Where We Are and Where We Need to Go Edison T. LiuxEdison T. LiuSearch for articles by this author Show More Genome Institute of Singapore, Singapore https://doi.org/10.1200/JCO.2003.01.137 First Page Full Text PDF Figures and Tables © 2003 by American Society of Clinical Oncology
Hemodynamics of the Upper Extremities in Subclavian Steal Syndrome
Authors: MARGARET C. CONRAD, JAMES F. TOOLE, RICHARD JANEWAY
Journal: Circulation (1965)

Digital flow, digital artery systolic pressure, resistance, pulse volume, pulse contour, and delay between right and left pulses were evaluated in the upper extremities of four patients with the subclavian steal syndrome. Studies were made preoperatively in all patients and following surgical reconstruction of the subclavian in three cases. Digital artery pressures were consistently lower on the side with the subclavian occlusion. Flow on the occluded side was equal to or higher than that in the opposite extremity except when a second, more distal occlusion was present. In each case there was a delay in the foot of the digital pulse on the occluded side and a more marked delay in the pulse peak. Distal to the occlusion the pulse amplitudes were decreased and the contours were abnormal. The amplitude of the digital pulse was markedly decreased with exercise of the affected extremity. The pulse delay and the disappearance of pulse in the radial artery during exercise previously described clinically has been confirmed by measurement.
Inflammatory mediators in the oesophagus.
Authors: G P Morgan, J G Williams
Journal: Gut (1994)

<h3>Abstract</h3> <b>Objectives:</b> To study the association between birth weight and blood pressure in children from multiple pregnancies (multiplets), mostly twins, to determine whether maternal or genetic factors are responsible for the association. <b>Design:</b> Cohort study. <b>Setting:</b> Southern Tasmania. <b>Subjects:</b> 888 children including 104 multiplets (32 monozygotic, 72 dizygotic). <b>Main outcome measure:</b> Systolic blood pressure (mm Hg). <b>Results:</b> Blood pressure decreased with birth weight and increased with current body mass. After adjustment for age and body mass, systolic blood pressure changed by −1.94 mm Hg (95% confidence interval −2.89 to −0.98) per 1 kg increase in birth weight of singletons. For multiplets, blood pressure changed by −7.0 mm Hg (−10.1 to −3.9) for each 1 kg increase in birth weight. This was little altered in within pair analyses (−5.3, −13.8 to 3.2) and was similar for both monozygotic (−6.5, −22.5 to 9.4) and dizygotic (−4.9, −15.8 to 6.0) pairs. <b>Conclusion:</b> Because the association between birth weight and blood pressure was largely unchanged in within pair analyses, exposures originating in the mother (such as nutritional status) cannot be wholly responsible. The association also remained within monozygotic pairs, suggesting that genetic predisposition is not wholly responsible either. The principal causal pathway must concern mechanisms within the fetoplacental unit. The stronger association in multiplets suggests that factors adversely influencing both blood pressure and birth weight are more prevalent in multiple pregnancies. <h3>Key messages</h3> Low birthweight is associated with high blood pressure from an early age Maternal factors, including diet during pregnancy, cannot wholly explain the association between fetal development and later risk of cardiovascular disease Because the association between blood pressure and birthweight remained in monozygotic twins, genetic factors are unlikely to be responsible for the association Important causes of the association seem to be operating within the fetoplacental unit during fetal life Further research should now focus on placental function and fetal exposures
Blood flow in psoriatic skin lesions: the effect of treatment
Authors: AMY KHAN, L. M. SCHALL, ETHEL TUR, H. I. MAIBACH, R. H. GUY
Journal: British Journal of Dermatology (1987)

Laser Doppler velocimetry (LDV) was used to assess the effect of treatment upon cutaneous blood flow in psoriatic skin lesions. The resolution of two separate plaques in each of seven subjects was followed. Six of the subjects received the Goeckerman regimen, the seventh was reated with psoralen-ultraviolet A (PUVA) therapy. Control LDV readings were taken from uninvolved skin sites during the treatment period. Cutaneous blood flow in the psoriatic lesions of the Goeckerman-treated patients decreased to levels comparable to those in uninvolved skin early in the course of treatment and significantly preceeded the observed clinical resolution from 4 to 8 days after initiation of therapy (P < 0.05). Visible flare-ups sometimes appeared when patients were untreated (over a weekend, for example) and these eruptions were accompanied by a transient elevation of LDV readings. Perfusion of the lesions of the PUVA-treated patient remained consistently higher than perfusion of uninvolved skin despite clinical healing. In a separate series of experiments, blood flow at the extensor surface of the forearm was measured in the skin of normal subjects, the uninvolved skin of psoriatic patients and the untreated lesional skin of psoriatic patients. While the lesional skin had significantly higher perfusion levels than uninvolved psoriatic or normal control skin (P < 0.01), there was no significant difference between blood flow to the uninvolved psoriatic skin of psoriatics and that to the skin of healthy controls.
Regulators should do more to protect whistleblowers, commission says
Authors: C. Dyer
Journal: BMJ (2013)

Organisations such as NHS trusts that fail to put in place effective whistleblowing arrangements should have their registration reviewed by regulators, an independent commission headed by a former Court of Appeal judge has concluded.1

Regulators such as the Care Quality Commission and the General Medical Council should do much more to protect whistleblowers and encourage them to come forward with their concerns, urged the whistleblowing commission, set up by the charity Public Concern at Work.

The eight member commission, headed by the retired appeal court judge Anthony Hooper, was set up after cases in which regulators failed to act on dangers to patient safety highlighted by whistleblowers at Mid Staffordshire NHS Foundation Trust and Winterbourne …
Dialysate partitioning in the Genius® batch hemodialysis system: Effect of temperature and solute concentration
Authors: Annemieke Dhondt, Sunny Eloot, Dirk D.E. Wachter, Rita D.E. Smet, Marie-Anne Waterloos, Griet Glorieux, Norbert Lameire, Pascal Verdonck, Raymond Vanholder
Journal: Kidney International (2005)
MASTOIDITIS WITHOUT APPARENT INVOLVEMENT OF THE MIDDLE EAR
Authors: Norman M. Heggie
Journal: JAMA (1924)

B. E. Hempstead<sup>1</sup>reports that only fifty-three cases of mastoiditis without apparent involvement of the middle ear have been reported in English and American literature, twenty-six of these being reported since Dabney's<sup>2</sup>review of the literature in 1915. The rarity of this condition prompts us to report two such cases that have recently occurred in our practice. <h3>Case 1.</h3> —H. P., a girl, aged 3, seen, Aug. 20, 1923, had had a swelling behind the right ear, and pain over the mastoid region, for one week. The temperature was 100. The hearing was normal. The nose, nasopharynx, larynx and both tympanic membranes were normal. The auricle was pushed forward, with a swelling over the mastoid region, especially marked at the tip. There was pain on pressure over the four principal points of the mastoid. As a diagnostic measure, a myringotomy was performed; this revealed no serum or pus.
Asian Medical Colleges and Fertility Control
Authors: Donald T. Rice
Journal: JAMA (1968)

Doctors and nurses must assume an increasing responsibility for designing and supervising the rapidly expanding programs for family planning and population control. This survey concentrates on the medical colleges of India which devote an average of 10.6 hours to the teaching of population dynamics, family planning programs, conception control techniques, and related social, cultural, educational, and motivational aspects. Ward rounds and family planning clinics provide observation and some experience during clerkship and internship. The time assigned to family planning has almost doubled in the past two years, and far exceeds the time allotted in US and United Kingdom medical schools. Only the two leading medical schools in Taiwan and two in Seoul can match this amount of teaching. These changes indicate a responsiveness to national needs and conditions.
Allergy to Insect Stings
Authors: W. P. Horen
Journal: JAMA (1972)

ABSTRACT To the Editor.— Unfortunately, somewhere in the course of editing and rewriting this error appeared, which I should have noticed. I meant to say that about 20% of Americans are believed to have a hereditary disposition to hypersensitivity, cited from N. P. Christy in the American Journal of Medicine (42:121, 1967).
A CONVENIENT ABDUCTION SPICA FOR PROLONGED IMMOBILIZATION OF THE HIP JOINT
Authors: Walter I. Galland
Journal: JAMA (1931)

The oft repeated aphorism that "we enter life through the brim of the pelvis, and leave it through the neck of the femur" is one that even today carries much ominous truth. The treatment of fracture of the neck of the femur in recent years by means of the Whitman spica has favorably altered the prognosis of this injury. However, the application of a full spica, extending from the ribs to the toes in an elderly patient, is an expedient often fraught with serious consequences, On account of the dorsal decubitus which the spica necessitates, plus the undue confinement of the costal cage, with consequent diminution of the respiratory excursion, the patient is exposed to the great danger of hypostatic pneumonia. Many patients who are treated for fracture of the neck of the femur in the classic spica succumb not to the fracture but to hypostasis in the pulmonary circulation.
AN IMPROVED DELIVERY SHEET
Authors: William Benbow Thompson
Journal: JAMA (1923)

This sheet was devised in an endeavor to develop a delivery drape that would permit the patient a moderate amount of freedom of motion without seriously disturbing delivery room technic. Sack-like leggings are sewed directly to elliptical openings in a sheet made of any heavy material, such as Indian Head. The central portion is reinforced with an extra thickness of the same material. Two tapes are sewed on the under side below the opening in the central section. All seams are double stitched. When it is desired to drape the patient, the limbs are thrust into the leggings, and the central aperture is arranged over the vulva. The assisting nurse then pins the attached tapes to the patient's gown, so that the lower portion of the reinforced area is tucked under the buttocks, and holds the drape closely to the vulva. Added security of arrangement may be obtained by the
Moonlighting: Making a Buck, Compassion, and Quality Control-Reply
Authors: Richard L. Cohen
Journal: JAMA (1990)

In Reply.—  I appreciate the opportunity to respond to Dr Piening since it permits me to clarify some points that could not be incorporated into my original, rather brief letter to the editor. I will take up each matter in the order in which he raises it:  Compassion was not the motivating force that led the faculty to agree to this arrangement. It was something called quality control , an issue that is of increasing concern in postgraduate medical education in Pennsylvania (and I assume in South Carolina, also).  The plan was not conceived by the faculty but by the hospital administration, which believed that some house officers were not exercising good judgment in the amount of moonlighting they were doing or in the degree of responsibility they were assuming in view of their level of training. At first, the faculty resisted the program, not wanting the added responsibility themselves.
The John Phillips Memorial Lecture: Urokinase.
Authors: Sol Sherry
Journal: Annals of Internal Medicine (1968)

s1 May 1968The John Phillips Memorial Lecture: Urokinase.Sol Sherry, M.D., F.A.C.P.Sol Sherry, M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-68-5-1139_3 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThough a safe and reliable form of thrombolytic therapy has not yet been established, progress continues in achieving this objective. Current interest centers about urokinase, a promising thrombolytic agent obtained from human urine. Since a major clinical trial to evaluate urokinase in the treatment of acute pulmonary embolism is scheduled to begin shortly, this presentation described the agent's development. The latter, requiring the close cooperation of the scientific community, the pharmaceutical industry, and the National Heart Institute, has resulted in [1] the production of preparations suitable for clinical investigation; [2] evidence that the intravenous administration of the agent produces a... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Philadelphia, Pennsylvania PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 May 1968Volume 68, Issue 5Page: 1139-1140KeywordsClinical trialsHeartPulmonary embolismUrine Issue Published: 1 May 1968 PDF DownloadLoading ...
Consumption coagulopathy after intra-amniotic urea.
Authors: M F Grundy, E R Craven
Journal: BMJ (1976)

Failure to confirm evidence for existence of two populations with duodenal ulcer A previous study on 339 patients attending a gastrointestinal unit suggested that patients with duodenal ulcer could be divided into two types.1 2 The distinction was based on maximal acid secretion and apparent differences in the prevalence of several clinical features, particularly family history, bleeding and perforation, and ABO blood grouping.In a further series of two groups of 100 patients referred consecutively to the same unit, however, no such distinction could be made.The results of this further study are presented here. Methods and resultsThe two groups of patients, who were investigated between October 1974 and October 1975, were proved radiologically and endoscopically to have duodenal ulcer.In every case the maximal acid output (MAO) was measured in response to 6 ,ag pentagastrin/kg total body weight (TBW).MAO was expressed as the amount of HC1 excreted/kg TBW, thereby reducing the difference between the sexes.3Mean MAO levels were used and tests of significance based on a comparison of these.Such tests have a better chance of detecting significance than tests based on contingency tables.The results in each of the two groups are given separately.The mean MAO levels (+SD) in the two groups were 0 48+0 19 and 0 49±+020 mmol HCl/kg TBW respectively (see table).In the previous
NICE recommends wider use of statins in draft guidelines
Authors: J. Wise
Journal: BMJ (2014)

The risk threshold for starting treatment with statins to prevent cardiovascular disease should be halved, says new draft guidance from the National Institute for Health and Care Excellence.1

The guidance, which is out for public consultation until 26 March, recommends that doctors use the QRISK2 assessment tool to identify people aged 40-74 who are likely to be at high risk of developing cardiovascular disease. It says that the threshold for starting preventive treatment with statins should be halved from a 20% risk …
Predictors of Improved Renal Function After Percutaneous Stent-Supported Angioplasty of Severe Atherosclerotic Ostial Renal Artery Stenosis
Authors: Thomas Zeller, Ulrich Frank, Christian Müller, Karlheinz Bürgelin, Lutz Sinn, Hans-Peter Bestehorn, Nancy Cook-Bruns, Franz-Josef Neumann
Journal: Circulation (2003)

Background— Percutaneous stent-supported angioplasty is a treatment option for atherosclerotic ostial renal artery stenosis. Improvement of renal function by such intervention, however, is controversial and thought to be limited to specific subsets, such as nondiabetic patients and bilateral stenoses. In this prospective study, we investigated predictors for improvement of renal function and blood pressure after renal artery stent placement. Methods and Results— The study included 215 consecutive patients with ostial renal artery stenosis of ≥70% diameter stenosis undergoing stent-supported angioplasty. The primary end point was decrease in serum creatinine concentration at 1 year; the secondary end point, decrease in average mean arterial blood pressure assessed by 24-hour monitoring. One-year follow-up was complete in 191 surviving patients. In 52% (99/191) of the patients, serum creatinine concentration decreased during 1-year follow-up. Median serum creatinine concentration dropped significantly from 1.21 mg/dL (quartiles: 0.92, 1.60 mg/dL) at baseline to 1.10 mg/dL (quartiles: 0.88, 1.50 mg/dL) at 1 year ( P =0.047). On average, mean arterial blood pressure decreased significantly, from 102±12 mm Hg (mean±SD) at baseline to 92±10 mm Hg at 1 year ( P &lt;0.001). Significant independent predictors of improved renal function were baseline serum creatinine (odds ratio [95% CI], 2.58 [1.35 to 4.94], P =0.004) and left ventricular function (OR 1.51 [1.04 to 2.21], P =0.032). Female sex, high baseline mean blood pressure, and normal renal parenchymal thickness were independent predictors for decreased mean blood pressure. Conclusions— Stent-supported angioplasty for severe ostial renal artery stenosis improves renal function and blood pressure in a broader spectrum of patients than previously thought.
Acute Lead Poisoning in Two Users of Illicit Methamphetamine
Authors: John V. Allcott
Journal: JAMA (1987)

Acute lead poisoning can present a difficult diagnostic dilemma, with symptoms that mimic those of hepatitis, nephritis, and encephalopathy. We report two cases in intravenous methamphetamine users who presented with abnormal liver function values, low hematocrit values, basophilic stippling of red blood cells, and elevated blood lead levels. Both patients excreted large amounts of lead in their urine after treatment with edetic acid, followed by resolution of their symptoms. Lead contamination was proved in one drug sample. Basophilic stippling of the red blood cells was the one key laboratory result that led to the definitive diagnosis in both cases.
New Outpost on the Trail of Polycythemia Vera
Authors: William S. Beck
Journal: New England Journal of Medicine (1976)

IN an Olympiad held in some academic stadium to judge the outstanding diseases, polycythemia vera would surely take several gold medals and one or two silvers. Class would show in several events — for example, durability as a study object and distinction of students, among whom were Galen, von Haller, Cohnheim, Labbé, Ludwig, Hayem, Bert, Vaquez, Türk and Osler, and later Haden, Wasserman, Dameshek, Gaisbock and more. Character and élan would tell in its interweaving history. When, for example, John H. Lawrence attempted therapeutic use of the radioactive phosphorus produced in the Berkeley cyclotron by his brother Ernest, it was . . .
ADDISON'S DISEASE DUE TO METASTATIC BRONCHOGENIC CARCINOMA
Authors: Jacques B. Wallach
Journal: JAMA (1952)

The frequency of adrenal involvement in bronchogenic carcinoma has been noted by many observers. In Willis'<sup>1</sup>series of 500 consecutive cancer necropsies, the most frequent adrenal metastases occurred in bronchogenic carcinoma, the incidence being 44%. In contrast, the incidence of adrenal involvement by all cancers was 9%. Willis<sup>1</sup>cited five additional series of bronchogenic carcinomas in which the incidence of adrenal metastases varied from 30% to 40%. In most cases, these metastases were bilateral and situated in the medulla. Jaffe<sup>2</sup>and Koletsky<sup>3</sup>reported the incidence of adrenal involvement as 40% and 45%, respectively; the glandular type of carcinoma was most often responsible. Koletsky's<sup>3</sup>series of 100 bronchogenic carcinomas comprised 10% of all cancers found by him at autopsy. At Queens General Hospital, bronchogenic carcinoma is a frequently encountered malignant tumor; it was found in 2.2% of all autopsies (5,030) performed here during the 10-year period
Primary Spinal Epidural Non-Hodgkin Lymphoma Demonstrated by FDG PET/CT
Authors: Linh Ho, David Valenzuela, Ali Negahban, Heidi Wassef
Journal: Clinical Nuclear Medicine (2010)

We report the F-18 fluorodeoxyglucose positron emission tomography/computed tomography appearance of a biopsy-proven primary epidural non-Hodgkin lymphoma involving the lower cervical and upper thoracic spine with a small hypermetabolic right middle lobe nodule in a 33-year-old man. The HIV-positive patient presented with mid- to low back pain for several days, which progressed to lower extremity weakness and urinary retention. Primary spinal epidural non-Hodgkin lymphoma is a rare form of malignancy, constituting approximately 0.1% to 3.3% of all lymphomas. In our case, the primary tumor appears as an intensely hypermetabolic soft-tissue mass involving the posterior epidural space from C6 through T9 levels.
John’s story
Authors: David Roche
Journal: BMJ (2008)

I was in the saloon when the boat slammed heavily off a wave. Somewhere forward there was a noise like someone throwing a sack of potatoes into a corner. John was crumpled in an undignified position, bum through the lower bunk rails and his knees up near his chin. We hoisted him out. 

The boat was travelling west, against the wind, through the huge grey waves of the Southern Ocean. Three thousand miles west of Cape Horn and 2000 miles short of New Zealand, we were constantly heeled against the prevailing westerly winds, and icy water regularly coursed the decks. The …
Detection of interleukin-5 messenger RNA and interleukin-5 protein in bronchial biopsies from asthma by nonradioactive in situ hybridization and immunohistochemistry
Authors: Takeshi Fukuda, Hirokazu Nakajima, Yasutsugu Fukushima, Ikuo Akutsu, Toshio Numao, Keiko Majima, Shinji Motojima, Yuichi Sato, Kiyoshi Takatsu, Sohei Makino
Journal: Journal of Allergy and Clinical Immunology (1994)