tbuckley/cabot-search huggingface dataset:
Incidence and Predictors of Drug-Eluting Stent Fracture in Human Coronary Artery
Authors: Gaku Nakazawa, Aloke V. Finn, Marc Vorpahl, Elena Ladich, Robert Kutys, Isidora Balazs, Frank D. Kolodgie, Renu Virmani
Journal: Journal of the American College of Cardiology (2009)
H2O2 Release from Human Granulocytes during Phagocytosis
Authors: Richard K. Root, Julia A. Metcalf
Journal: Journal of Clinical Investigation (1977)

Normal and cytochalasin B-treated human granulocytes have been studied to determine some of the interrelationships between phagocytosis-induced respiration and superoxide and hydrogen peroxide formation and release into the extracellular medium by intact cells. By using the scopoletin fluorescent assay to continuously monitor extracellular hydrogen peroxide concentrations during contact of cells with opsonized staphylococci, it was demonstrated that the superoxide scavengers ferricytochrome c and nitroblue tetrazolium significantly reduced the amount of H2O2 released with time from normal cells but did not abolish it. This inhibitory effect was reversed by the simultaneous addition of superoxide dismutase (SOD), whereas the addition of SOD alone increased the amount of detectable H2O2 in the medium. The addition of sodium azide markedly inhibited myeloperoxidase-H2O2-dependent protein iodination and more than doubled H2O2 release, including the residual amount remaining after exposure of the cells to ferricytochrome c, suggesting its origin from an intracellular pool shared by several pathways for H2O2 catabolism.
Nuclear factor κB in liver disease
Authors: N J GALLAGHER, L S YOUNG
Journal: Gut (1999)

Phosphorylation of inhibitor of B (I B) proteins is an important step in the activation of the transcription nuclear factor B (NF-B) and requires two I B kinases, IKK1 (IKK ) and IKK2 (IKK ).Mice that are devoid of the IKK2 gene had extensive liver damage from apoptosis and died as embryos, but these mice could be rescued by the inactivation of the gene encoding tumor necrosis factor receptor 1. Mouse embryonic fibroblast cells that were isolated from IKK2-/embryos showed a marked reduction in tumor necrosis factor-(TNF-)-and interleukin-1induced NF-B activity and an enhanced apoptosis in response to TNF-.IKK1 associated with NF-B essential modulator (IKK /IKKAP1), another component of the IKK complex.These results show that IKK2 is essential for mouse development and cannot be substituted with IKK1.
Epidemiology of methicillin-resistant Staphylococcus aureus lineages in five major African towns: emergence and spread of atypical clones
Authors: S. Breurec, S.B. Zriouil, C. Fall, P. Boisier, S. Brisse, S. Djibo, J. Etienne, M.C. Fonkoua, J.D. Perrier-Gros-Claude, R. Pouillot, C.E. Ramarokoto, F. Randrianirina, A. Tall, J.M. Thiberge, F. Laurent, B. Garin
Journal: Clinical Microbiology and Infection (2010)
Expression of vascular endothelial-cadherin and epithelial cadherin in non-small cell lung cancer and their clinical significances
Authors: Juan Tao, Hong Chen
Journal: European Respiratory Journal (2012)

To assess the expression of vascular endothelial cadherin (VE-cadherin) and epithelial cadherin (E-cadherin) in human non-small cell lung cancer (NSCLC) tissues and to correlate their expression with the clinicopathological characteristics of NSCLC. The expression of them were examined by immunohistochemistry in NSCLC tissues from 97 patients and their adjacent non-neoplastic tissues.The mRNA of them were detected by RT-PCR in 18 specimens.The positive rates of them were 51.5% and 42.3%, respectively. The positive rate of VE-cadherin was higher than that in adjacent non-neoplastic tissues 0% (P
Crutch Walker's Shoulder
Authors: R G Pringle
Journal: Journal of the Royal Society of Medicine (2001)

Mr Davies and his colleagues conclude that, in a patient with Cushing's disease or avascular necrosis (AVN) at other sites, shoulder symptoms when crutch walking ‘should be enquired about and investigated radiographically’ (July 2001 JRSM, pp. 348-349). Crutch walking has wider relevance to AVN.

In 1983 I reported the cases of two perhaps osteoporotic but otherwise healthy women aged 73 and 59 who developed AVN of the humeral head as a result of crutch walking following isolated femoral neck fracture treated by internal fixation1. In both cases the condition was self-limiting and in one it was detected only as a result of full examination for medicolegal purposes seven months after the injury. I presented also a third patient who had used a walking aid in the right hand for over 10 years after unsuccessful hip replacement and who had developed glenohumeral osteoarthritis, the appearances of which were suggestive of previous aseptic necrosis.

I suggested that the condition probably was more common than appreciated because in those who use crutches for a limited period the symptoms were low-grade and spontaneous resolution takes place. With prolonged crutch walking, however, the condition might lead to glenohumeral osteoarthritis. Some support for this view was provided by a later paper reporting bilateral osteonecrosis of the humeral heads in a wheelchair-dependent T8 paraplegic2.
Preclinical phase II studies in human tumor xenografts: A European multicenter follow-up study
Authors: S.P. Langdon, H.R. Hendriks, B.-J.M. Braakhuis, G. Pratesi, D.P. Berger, Ø. Fodstad, H.H. Fiebig, E. Boven
Journal: Annals of Oncology (1994)
Socio-economic status does not influence lung function decline in children with cystic fibrosis in Australia
Authors: Liam Welsh, Sarath Ranganathan, Colin Robertson
Journal: European Respiratory Journal (2013)

Introduction: Low socio-economic status (SES) has previously been associated with poorer pulmonary outcomes in children with cystic fibrosis (CF). However, previous research has focused on cross-sectional data and longitudinal data are currently lacking for Australia. The aim of this study was to determine the influence of SES on the rate of decline in lung function in children with CF in a universal healthcare setting. Methods: We collated best annual lung function data from children and adolescents who had transferred from the Royal Children’s Hospital (RCH), Melbourne CF service to adult care within the previous five years. SES was determined using the Socio-Economic Index for Areas (SEIFA) from the Australian Bureau of Statistics household census conducted in 2011. SES was categorised according to decile (i.e. 1 through to 10) with 1 representing the most disadvantaged and 10 the least disadvantaged. A mixed regression model was used to assess decline in lung function according to SES decile. Results: Longitudinal lung function data (range 5–20 years) were obtained for 98 patients with CF (55 male, 46% ΔF508 homozygous, 53% diagnosed by newborn screening). There were a median of 12 (range 3–16) observations per patient (i.e. 12 years of data) and 1127 observations in total. The mean annual rate of decline in FEV1 was -0.12 z-score. There were no statistically significant differences in the rate of decline in FEV1 z-score according to SES decile (e.g. -0.06 vs -0.08 FEV1 z-score per year, 1 vs 10 decile). Conclusion: In a universal healthcare setting SES does not influence pulmonary outcome, as assessed by rate of decline in FEV1, in children and adolescents with CF.
Asthma exacerbation with fluticasone propionate/formoterol fumarate combination therapy versus its individual components
Authors: Sanjeeva Dissanayake, Mark Lomax, Kirsten Kaiser, Tammy McIver
Journal: European Respiratory Journal (2012)

Background:  Asthma control remains suboptimal in many patients as indicated by exacerbations and deteriorating symptoms. This pooled analysis of up to 5 randomized double-blind studies assessed the effects of fluticasone propionate (FLUT) and formoterol fumarate (FORM) in a single aerosol inhaler (FLUT/FORM) on asthma exacerbations.   Methods:  Adults and adolescents with asthma (all severities) were randomized to FLUT/FORM (100/10, 250/10 or 500/20 μg bid), or equivalent nominal doses of FLUT (100, 250 or 500 μg bid; 5 studies) or FORM (10 μg bid; 3 studies) for 8 or 12 weeks. The proportion of patients with an exacerbation was assessed. Mild-to-moderate exacerbation was defined as peak expiratory flow rate >30% below baseline, awakening at night due to asthma or rescue medication use >3–4 times/day (each on ≥2 consecutive days); severe exacerbation was need for additional therapy, or emergency visit/hospitalization due to asthma.   Results:  Significantly fewer patients reported exacerbations with FLUT/FORM than FLUT (27% [172/641] vs 33% [211/643]; odds ratio [OR] 0.75; 95% CI 0.59, 0.96) or FORM (18% [62/341] vs 31% [108/345]; OR 0.49; 95% CI 0.34, 0.70). The annualised exacerbation rate was significantly lower with FLUT/FORM than FLUT (ratio 0.69; 95% CI 0.61, 0.79; p   Conclusion:  FLUT/FORM significantly reduces the risk of reported asthma exacerbations (any severity) compared with its individual components.
Chronic rhinosinusitis and the prevalence of asthma
Authors: Kåre Håkansson, Simon Francis Thomsen, Jann Mortensen, Lars Konge, Vibeke Backer, Christian von Buchwald
Journal: European Respiratory Journal (2013)

Background: Chronic rhinosinusitis (CRS) is a common health problem with significant medical costs and impact on general health. It is sub classified with (CRSwNP) or without (CRSsNP) nasal polyps. CRS frequently co-exist with asthma but, to date, this association remains poorly studied and unexplained.  Methods: A clinical study comprising 57 patients with recalcitrant CRS and 20 control subjects scheduled for septoplasty; all were consecutively included. Allergy was assessed by skin prick test (SPT) or radioallergosorbent (RAST) test; moreover, nasal endoscopy, 14-day-twice-daily-peak-flow registration, spirometry and reversibility test was performed. In selected cases, a bronchial challenge test was carried out and/or expiratory NO (eNO) was measured. Upper as well as lower airway disease was thus clinically classified according to international guidelines.  Results: Among the 57 patients, 43 and 10, respectively, had CRSwNP and CRSsNP. Four patients were difficult to classify and therefore categorized as atypical (e.g. endoscopy with a single polyp or cobblestone mucosa).Thirty patients with CRSwNP (odds ratio [OR] = 6.9 [1.8-27.9], p=0.001), 3 patients with CRSsNP (30 %), 3 with atypical CRS (75 %) and 5 control subject (25 %) had asthma. Among patients with co-existing CRSwNP and asthma, 34% were atopic which is comparable to the background population.  Conclusion: In comparison with previous studies, we found a surprisingly strong association between upper and lower airway disease among patients with recalcitrant CRSwNP. We hypothesize a common pathology with identical inflammatory changes throughout the airway in CRSwNP, i.e. the united airways.
Topical maxacalcitol for the treatment of psoriasis vulgaris: a placebo-controlled, double-blind, dose-finding study with active comparator
Authors: None N.barker, None Ashton, None Marks, None Harris, None Berth-Jones
Journal: British Journal of Dermatology (1999)

Journal Article Topical maxacalcitol for the treatment of psoriasis vulgaris: a placebo‐controlled, double‐blind, dose‐finding study with active comparator Get access J.N.W.N. barker, J.N.W.N. barker Skin Therapy Research Unit, St John's Institute of Dermatology, St Thomas' Hospital, London SE1 7EH, U.K. Dr Barker E‐mail: jonathan.barker@kcl.ac.uk Search for other works by this author on: Oxford Academic Google Scholar R.E. Ashton, R.E. Ashton Department of Dermatology, Royal Hospital Haslar, Portsmouth PO12 2AA, U.K. Search for other works by this author on: Oxford Academic Google Scholar R. Marks, R. Marks Department of Dermatology, University of Wales College of Medicine, Cardiff CF4 4XW, U.K. Search for other works by this author on: Oxford Academic Google Scholar R.I. Harris, R.I. Harris Parexel International, Uxbridge, U.K. Search for other works by this author on: Oxford Academic Google Scholar J. Berth‐Jones J. Berth‐Jones Department of Dermatology, Walsgrave Hospital, Coventry CV2 2DX, U.K. Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 141, Issue 2, 1 August 1999, Pages 274–278, https://doi.org/10.1046/j.1365-2133.1999.02975.x Published: 01 August 1999
Oncogenicity in Marmosets of HL-23V, a Type C Oncornavirus Isolated From Human Leukemic Cells, and Comparison With Simian Sarcoma Virus Type 1 (SSV-1/SSAV-1) 2
Authors: C. M. Bergholz, L. G. Wolfe, F. Deinhardt, B. Thakkar, B. Marczynska
Journal: JNCI Journal of the National Cancer Institute (1977)

Journal Article Oncogenicity in Marmosets of HL-23V, a Type C Oncornavirus Isolated From Human Leukemic Cells, and Comparison With Simian Sarcoma Virus Type 1 (SSV-1/SSAV-1) Get access C. M. Bergholz, C. M. Bergholz Search for other works by this author on: Oxford Academic PubMed Google Scholar L. G. Wolfe, L. G. Wolfe Search for other works by this author on: Oxford Academic PubMed Google Scholar F. Deinhardt, F. Deinhardt Search for other works by this author on: Oxford Academic PubMed Google Scholar B. Thakkar, B. Thakkar Search for other works by this author on: Oxford Academic PubMed Google Scholar B. Marczynska B. Marczynska Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 58, Issue 4, April 1977, Pages 1041–1046, https://doi.org/10.1093/jnci/58.4.1041 Published: 01 April 1977 Article history Received: 21 June 1976 Accepted: 27 September 1976 Published: 01 April 1977
Evaluation of epidemiologic risk and performance of tuberculosis control program in health regions of the State of Santa Catarina, Brazil, from 2003 to 2010
Authors: Sergio Mendonça, Selma Cristina Franco
Journal: European Respiratory Journal (2014)

Introduction : Tuberculosis is still a severe public health problem worldwide. In Brazil, the National Tuberculosis Control Program (PNCT) of the Ministry of Health recommends that prevention, diagnosis and treatment should be performed by the municipalities, preferably in primary care settings. The States are responsible to perform actions of monitoring and evaluation of municipal programs grouped by health regions.

Objectives : Evaluate the epidemiologic risk and performance of PNCT in health regions in the State of Santa Catarina, Brazil.

Methods : An ecological study was conducted from 2003 to 2010, creating risk and performance scores for the 21 health regions. Based on the medians distribution of 4 risk indicators, regions were categorized as low, intermediate and high risk. The same procedure was made for 11 performance indicators, allowing to categorize regions as bad, intermediate and good performance. Finally, a severity index for each region was created based on the combination of risk and performance scores.

Results : We observed 6 low, 9 intermediate and 6 high risk regions as well as 6 low, 9 intermediate and 6 good performance regions, with significant differences (p<0,001) in the indicators. The severity index of the regions ranged 2.5 times and showed distinct geographical distribution of risk and performance aspects concerning Tuberculosis in the State.

Conclusion : Differences in epidemiologic risk and performance of Tuberculosis Program in the regions constitute a big challenge for local public health authorities and makes evident a potential for improving the quality of Tuberculosis care.
Activity and tolerance of XL647 in NSCLC patients with acquired resistance to EGFR-TKIs: Preliminary results of a phase II trial
Authors: V. A. Miller, H. A. Wakelee, P. N. Lara, J. Cho, N. M. Chowhan, D. Costa, N. Vrindavanam, R. Yanagihara, N. Pennell, T. J. Lynch
Journal: Journal of Clinical Oncology (2008)

8028 Background: XL647 is an orally bioavailable small molecule inhibitor of RTKs (EGFR, HER2, and VEGFR2) involved in tumor growth, angiogenesis, and metastasis. First-generation EGFR TKIs are active in NSCLC particularly in pts with EGFR mutations and amplification. However, pts who respond to erlotinib or gefitinib relapse, and no standard therapy exists. In ∼50% of cases this is associated with a second EGFR point mutation (T790M). Preclinically, XL647 inhibits growth of cell lines such as H1975 which also harbor T790M. This study examines the activity of XL647 in pts who have relapsed after initial benefit from erlotinib or gefitinib. Methods: Simon two- stage study with primary endpoint of best confirmed response rate. In case of ≥ 1 response in Stage 1 the study will proceed to Stage 2. Eligibility: Adult pts with relapsed or recurrent NSCLC (Stage IIIB or IV) with documented progressive disease (PD) after benefit including stable disease (SD) from single agent erlotinib or gefitinib administered for ≥12 wks OR who have known T790M. Treatment: XL647 as a single daily dose of 300 mg on a 28-day cycle. Assessment: Response is evaluated by RECIST. EGFR and KRAS2 from circulating plasma DNA are being analyzed using Scorpion ARMS technology (DxS, UK) and also from tumor tissue if available. Results: Twenty-three pts (19F/4M) with a median age of 71 yrs (range 27–90) have been enrolled. One pt had a PR and 7 pts had SD at their first assessment; 14 pts are too early to evaluate; 1 pt discontinued before first assessment with unrelated cardiac arrhythmia. Pts have commonly reported improvement in symptoms while on study. Two pts with SD have discontinued with AEs, one had drug-related grade (g) 4 pulmonary emboli, and one drug-related g2 creatinine elevation (pt had one functional kidney). The most common AEs are g1 diarrhea, rash, and nausea, and g1/2 fatigue. Analysis of plasma from a subset of pts did not reveal common mutations in EGFR or KRAS2. A T790M mutation was detected in tumor tissue from 1pt. Conclusions: XL647 has activity and is well-tolerated in this population. Accrual has been brisk and with the observed partial response the trial has proceeded to Stage 2. Author Disclosure Employment or Leadership Consultant or Advisory Role Stock Ownership Honoraria Research Expert Testimony Other Remuneration Exelixis
Chemical exposures other than arsenic are probably not important risk factors for squamous cell carcinoma, basal cell carcinoma and malignant melanoma of the skin
Authors: C. Kennedy, C.D. Bajdik, R. Willemze, J.N. Bouwes Bavinck
Journal: British Journal of Dermatology (2005)

Journal Article Chemical exposures other than arsenic are probably not important risk factors for squamous cell carcinoma, basal cell carcinoma and malignant melanoma of the skin Get access C. Kennedy, C. Kennedy Department of Dermatology, Leiden University Medical Center, PO Box 9600, 2300 RC Leiden, the Netherlands *Cancer Control Research Program, BC Cancer Agency, Canada Search for other works by this author on: Oxford Academic Google Scholar C.D. Bajdik, C.D. Bajdik Department of Dermatology, Leiden University Medical Center, PO Box 9600, 2300 RC Leiden, the Netherlands *Cancer Control Research Program, BC Cancer Agency, Canada Search for other works by this author on: Oxford Academic Google Scholar R. Willemze, R. Willemze Department of Dermatology, Leiden University Medical Center, PO Box 9600, 2300 RC Leiden, the Netherlands *Cancer Control Research Program, BC Cancer Agency, Canada Search for other works by this author on: Oxford Academic Google Scholar J.N. Bouwes Bavinck J.N. Bouwes Bavinck Department of Dermatology, Leiden University Medical Center, PO Box 9600, 2300 RC Leiden, the Netherlands *Cancer Control Research Program, BC Cancer Agency, Canada J.N. Bouwes Bavinck. E‐mail: J.N.Bouwes_Bavinck@lumc.nl Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 152, Issue 1, 1 January 2005, Pages 194–197, https://doi.org/10.1111/j.1365-2133.2005.06411.x Published: 01 January 2005
Foreign-Body Tumorigenesis in Mice: Most Probable Number of Originator Cells2
Authors: K. Gerhard Brand, Lance C. Buoen, Inge Brand
Journal: JNCI Journal of the National Cancer Institute (1973)

Journal Article Foreign-Body Tumorigenesis in Mice: Most Probable Number of Originator Cells Get access K. Gerhard Brand, K. Gerhard Brand Search for other works by this author on: Oxford Academic PubMed Google Scholar Lance C. Buoen, Lance C. Buoen Search for other works by this author on: Oxford Academic PubMed Google Scholar Inge Brand Inge Brand Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 51, Issue 3, September 1973, Pages 1071–1074, https://doi.org/10.1093/jnci/51.3.1071 Published: 01 September 1973 Article history Received: 16 April 1973 Accepted: 29 May 1973 Published: 01 September 1973
c-Myc expression in human anagen hair follicles
Authors: C. Rumio, E. Donetti, A. Imberti, I. Barajon, E. Prosperi, M.F. Brivio, A. Boselli, E. Lavezzari, S. Veraldi, M. Bignotto, P. Castano
Journal: British Journal of Dermatology (2000)

The hair follicle represents a very attractive organ system for studying the precise balance between cell proliferation, growth, differentiation, and death of cells, because it periodically and regularly regenerates, retaining its morphogenetic signals throughout its life. One of the most intriguing oncogenes which is able to induce both cell growth and apoptosis, depending upon the environmental conditions, is c-myc. The aim of the present study was to investigate its presence and localization in human hair follicles by immunohistochemistry and immunofluorescence. Our observations demonstrated the consistent presence of two clusters of c-Myc-expressing cells in anagen follicles, located in two annular regions of the inner root sheath, at the border between cells characterized by putative trichohyalin granules and cells which are keratinized. The lower group belongs to Henle's layer, while the upper group belongs to Huxley's layer. c-Myc oncoprotein seems to favour apoptosis/differentiation and may be a marker for terminal differentiation of trichocytes, at least in the inner root sheath. Our findings agree with the interpretation that the complex morphology of the hair follicle reflects its complex function; the extrusion of a highly organized multicellular structure, the hair shaft, driven by another highly organized multicellular structure, the inner root sheath.
Maternal Modification of Antigenicity: An Immunologic Mechanism to Ensure Survival of Mammalian Fetuses
Authors: Delta E. Uphoff
Journal: JNCI Journal of the National Cancer Institute (1970)

It was postulated that maternal modification of antigenicity was the immunologic mechanism that prevents the rejection of the hybrid fetus as an allograft. Growth and function of hybrid tissue were tested in a parental strain of AKR mice. These mice were preimmunized by rejection of CBA, (CBA × AKR)F1, and (AKR × CBA)F1 skin allografts, exposed to lethal total-body X irradiation, and inoculated with the 3 types of allogeneic marrow. Variations in survival patterns determined whether the bone marrow graft was established and could function in presensitized recipients. Pre-immunization against CBA tissue prevented the establishment of a CBA marrow graft but only interfered with the function of hybrid marrow grafts. Preimmunization with hybrid skin prevented normal function of CBA marrow and, to a lesser extent, the (CBA × AKR)F1 marrow; it did not, however, impede the growth and function of (AKR × CBA)F1 marrow. Surviving chimeras were tolerant to skin allografts containing CBA tissue antigens, even though they had previously rejected similar skin allografts. Normal growth and function of normal adult marrow from (♀AKR × ♂CBA)F1 donors in AKR recipients, preimmunized against paternal antigens by contact with hybrid tissue, were analogous with a maternal-fetal relationship, but without mechanical barriers or undeveloped antigenicity characteristic of fetal tissue. These experiments demonstrated that this immunologie mechanism alone could ensure survival of (♀AKR × ♂CBA)F1 tissue. However, other supplementary mechanisms may also exist to provide additional survival advantage in the fetus.