Acute Pancreatitis Associated with Chemotherapy for Germ Cell Tumors in Two Patients
Authors: MARK A. SOCINSKI
Journal: Annals of Internal Medicine (1988)

Brief Reports1 April 1988Acute Pancreatitis Associated with Chemotherapy for Germ Cell Tumors in Two PatientsMARK A. SOCINSKI, M.D., MARC B. GARNICK, M.D.MARK A. SOCINSKI, M.D.Search for more papers by this author, MARC B. GARNICK, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-108-4-567 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe gastrointestinal toxicity of chemotherapy has been well reviewed (1). Although acute pancreatitis is an uncommon side effect, it has been reported with L-asparaginase (2), azathioprine (3), estrogens (4), prednisone (4), cytarabine (5), and various regimens of combination chemotherapy (6, 7). We describe two patients with germ cell tumors who developed acute pancreatitis during therapy with cisplatin, bleomycin, and vinblastine.Patient 1: A 24-year-old woman presented with a right adnexal mass. Ultrasound revealed an 11 X 7 cm complex mass. Exploratory laparotomy showed a tumor involving the right ovary that on frozen section was consistent with a dysgerminoma.A unilateral...References1. MITCHELLSCHEIN EP. Gastrointestinal toxicity of chemotherapeutic agents. Semin Oncol. 1982;9:52-64. MedlineGoogle Scholar2. LANDSUTOWFERNBACHLANEWILLIAMS VWDDT. Toxicity of L-asparaginase in children with acute leukemia. Cancer. 1972;30:339-47. CrossrefMedlineGoogle Scholar3. KAWANISHIRUDOLPHBULL HEF. Azathioprine-induced acute pancreatitis [Letter]. N Engl J Med. 1973;289:357. CrossrefMedlineGoogle Scholar4. MALLORYKERN AF. Drug-induced pancreatitis: a critical review. Gastroenterology. 1980;78:813-20. CrossrefMedlineGoogle Scholar5. SIEMERSFRIEDENBERGNORFLEET RWR. High-dose cytosine arabinoside-associated pancreatitis. Cancer. 1985;56:1940-2. CrossrefMedlineGoogle Scholar6. NEWMANELLIS CD. Pancreatitis during combination chemotherapy. Clin Oncol. 1979;5:83-4. MedlineGoogle Scholar7. PUCKETTBUTLERMCFARLAND JWJ. Pancreatitis and combination chemotherapy [Letter]. Ann Intern Med. 1982;97:453. LinkGoogle Scholar8. YEUNGHAIDAKBROWNANDERSON KDJD. Metastasis-induced acute pancreatitis in small cell bronchogenic carcinoma. Arch Intern Med. 1979;139:552-4. CrossrefMedlineGoogle Scholar9. SPIEGALMEGRATH RI. Tumor lysis pancreatitis. Med Pediatr Oncol. 1979;7:169-72. CrossrefMedlineGoogle Scholar10. PRATTPUDDON WR. Plant alkaloids, enzymes, and miscellaneous cancer drugs. In: The Anticancer Drugs. Vol 1. New York: Oxford University Press; 1979:229-33. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: MARK A. SOCINSKI, M.D.; MARC B. GARNICK, M.D.Affiliations: Harvard Medical School Boston, Massachusetts PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byAntineoplastic agents associated with the development of drug-induced pancreatitisAcute pancreatitis induced by drugs used in the treatment of solid malignant neoplasmsAcute Pancreatitis Induced by Polatuzumab-Vedotin-Piiq in Combination With Bendamustine and Rituximab for Diffuse Large B-Cell LymphomaDrug-Induced Acute Pancreatitis: An Evidence-Based ReviewAcute pancreatitis secondary to ifosfamideCytostatics and immunosuppressive drugsDrug-Induced Acute PancreatitisPancreatitis in Germ Cell TumorsJ. W. Sweetenham, BSc, GM. Mead, DM 1 April 1988Volume 108, Issue 4Page: 567-568KeywordsAcute pancreatitisChemotherapyCombination chemotherapyEstrogensGerm cellsLaparotomyOvariesPatient advocacyToxicityUltrasound imaging ePublished: 1 December 2008 Issue Published: 1 April 1988 PDF downloadLoading ...