tbuckley/cabot-search huggingface dataset:
It takes two to talk: A second-person neuroscience approach to language learning
Authors: Supriya Syal, Adam K. Anderson
Journal: Behavioral and Brain Sciences (2013)

Abstract Language is a social act. We have previously argued that language remains embedded in sociality because the motivation to communicate exists only within a social context. Schilbach et al. underscore the importance of studying linguistic behavior from within the motivated, socially interactive frame in which it is learnt and used, as well as provide testable hypotheses for a participatory, second-person neuroscience approach to language learning.
Continuing Medical Education and Quality Improvement: A Match Made in Heaven?
Authors: Alexander M. Djuricich
Journal: Annals of Internal Medicine (2012)

Letters3 July 2012Continuing Medical Education and Quality Improvement: A Match Made in Heaven?Alexander M. Djuricich, MDAlexander M. Djuricich, MDFrom Indiana University School of Medicine, Indianapolis, IN 46202.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-157-1-201207030-00021 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:I applaud Shojania and colleagues (1) for providing a much-needed description of the importance of QI in the CME arena. Clinicians absolutely need to understand not only the medical content to care for patients but also the science of improvement within the practice context to optimize patient outcomes. Continuing medical education is the perfect avenue through which physicians can learn this.It is encouraging that the Accreditation Council for Graduate Medical Education understands the importance of QI as a skill for all future physicians and has required that residents, as part of practice-based learning and improvement competency, ...References1. Shojania KG, Silver I, Levinson W. Continuing medical education and quality improvement: a match made in heaven? Ann Intern Med. 2012;156:305-8. [PMID: 22351715] LinkGoogle Scholar2. Armstrong G, Headrick L, Madigosky W, Ogrinc G. Designing education to improve care. Jt Comm J Qual Patient Saf. 2012;38:5-14. [PMID: 22324186] CrossrefMedlineGoogle Scholar3. Hawkins RE, Weiss KB. Commentary: Building the evidence base in support of the American Board of Medical Specialties maintenance of certification program. Acad Med. 2011;86:6-7. [PMID: 21191200] CrossrefMedlineGoogle Scholar4. Dubravec MS. The burdensome maintenance of certification process [Letter]. Ann Allergy Asthma Immunol. 2011;106:351. [PMID: 21457891] CrossrefMedlineGoogle Scholar5. Patow CA, Karpovich K, Riesenberg LA, Jaeger J, Rosenfeld JC, Wittenbreer M, et al. Residents' engagement in quality improvement: a systematic review of the literature. Acad Med. 2009;84:1757-64. [PMID: 19940586] CrossrefMedlineGoogle Scholar Author, Article, and Disclosure InformationAffiliations: From Indiana University School of Medicine, Indianapolis, IN 46202.Disclosures: None disclosed. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoContinuing Medical Education and Quality Improvement: A Match Made in Heaven? Kaveh G. Shojania , Ivan Silver , and Wendy Levinson Metrics 3 July 2012Volume 157, Issue 1Page: 77-78KeywordsConflicts of interestForecastingGraduate medical educationHealth careMedical educationPatientsQuality improvementSafety ePublished: 3 July 2012 Issue Published: 3 July 2012 Copyright & PermissionsCopyright © 2012 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Effects of Marihuana on Sleeping States
Authors: Frank R. Freemon
Journal: JAMA (1972)

<h3>To the Editor.—</h3> It is hard to pick up a journal, be it medical or otherwise, without reading the conclusion of an expert or a committee that marihuana does not cause physical dependence, ie, that abrupt discontinuance of marihuana after long-term use does not cause physiologic withdrawal effects. Utilizing the technique of allnight polygraphic recording, I have just completed a pilot study which suggests that marihuana can produce physiologic withdrawal effects. All-night polygraphic recordings reveal that abrupt discontinuance of many drugs (heroin, morphine, alcohol, barbiturates, amphetamines, and many sedatives and sleeping pills) after they have been given for several days produces a characteristic drugwithdrawal syndrome characterized by difficulty in falling asleep, more frequent awakenings, shorter time from falling asleep to the first rapid eye movement (REM) period, and an increased amount of the REM stage of sleep.<sup>1,2</sup>All of these findings are physiologic withdrawal effects and indicate that these
Case 46-1974
Authors: Robert M. Glickman, James J. Galdabini
Journal: New England Journal of Medicine (1974)

Presentation of CaseA 69-year-old woman was admitted to the hospital because of a question of gastric carcinoma.She was well until 15 years previously, when she was twice admitted to another hospital because of repeated vomiting. Since that time she vomited periodically, especially when under emotional stress and after eating certain foods. Six months before entry she began to experience low substernal discomfort after walking less than one block, with no relief from nitroglycerin. During the two months before admission the pain was almost continuous. Two weeks before entry an upper gastrointestinal series revealed an infiltrative lesion of the . . .
West Nile Susceptibility
Authors: Tracy Hampton
Journal: JAMA (2008)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
THE ROLE OF SERUM COMPLEMENT IN CHEMOTAXIS OF LEUKOCYTES IN VITRO
Authors: Peter A. Ward, Charles G. Cochrane, Hans J. Müller-Eberhard
Journal: The Journal of Experimental Medicine (1965)

By the use of chambers containing two compartments with an interposed micropore filter, chemotaxis of polymorphonuclear leukocytes (PMN's) in vitro was studied employing various agents that fixed serum complement (C'). Antigen-antibody complexes, zymosan, and aggregated human gamma globulin, in the presence of fresh rabbit, guinea pig, or mouse serum resulted in the migration of PMN's through the micropore filter. Pepsin-degraded rabbit antibody or unaltered duck serum containing antibody did not exhibit such activity after addition of antigen. Heating of the serum before treatment or the presence of EDTA prevented the generation of the chemotactic factor. The chemotactic factor could not be generated in whole serum from rabbits genetically deficient in C'. However, the defect in this rabbit serum could be corrected by addition of rabbit or human C'6. Serum of B10.D2 mice deficient in hemolytic C' also yielded poor chemotactic activity. Interaction of the first four reacting components of guinea pig C' did not result in significant chemotactic activity unless guinea pig euglobulin with heat labile components was also present. In rabbit serum, C'5 and C'6, when "activated" by interaction with the first four reacting components, behaved like a protein-protein complex and exhibited marked chemotactic activity. By employing conditions favoring dissociation of the complex, the individual components were isolated and shown to be chemotactically inactive. Upon recombination of the two components, however, activity reappeared. Using another approach, the C'5-C'6 complex was isolated intact, and shown to be chemotactically active while other fractions not containing these components were not active. It is postulated that the C'5-C'6 complex is the active chemotactic factor generated in serum after the addition of C'-fixing agents.
Genital Herpes Simplex Virus Infections: Clinical Manifestations, Course, and Complications
Authors: LAWRENCE COREY
Journal: Annals of Internal Medicine (1983)

The clinical course and complications of 268 patients with first episodes and 362 with recurrent episodes of genital herpes infection were reviewed. Symptoms of genital herpes were more severe in women than in men. Primary first-episode genital herpes was accompanied by systemic symptoms (67%), local pain and itching (98%), dysuria (63%), and tender adenopathy (80%). Patients presented with several bilaterally distributed postularulcerative lesions that lasted a mean of 19.0 days. Herpes simplex virus was isolated from the urethra, cervix, and pharynx of 82%, 88%, and 13% of women with first-episode primary genital herpes, and the urethra and pharynx of 28% and 7% of men. Complications included aseptic meningitis (8%), sacral autonomic nervous system dysfunction (2%), development of extragenital lesions (20%), and secondary yeast infections (11%). Recurrent episodes were characterized by small vesicular or ulcerative unilaterally distributed lesions that lasted a mean of 10.1 days. Systemic symptoms were uncommon and 25% of recurrent episodes were asymptomatic. The major concerns of patients were the frequency of recurrences and fear of transmitting infection to partners or infants.
Reviews and Notes: The Medical Care of Terminally Ill Patients
Authors: Georgia L. Newman
Journal: Annals of Internal Medicine (1994)

Literature of Medicine15 November 1994Reviews and Notes: The Medical Care of Terminally Ill PatientsGeorgia L. NewmanGeorgia L. NewmanThe Oberlin Clinic, Inc., Oberlin, OH 44074.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-121-10-199411150-00023 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail The Medical Care of Terminally Ill PatientsRobert E. Enck. 202 pages. Baltimore, Maryland: The Johns Hopkins University Press; 1994. $28.95.“Doctor?” The hospice nurse was on the phone. “Your patient with pancreatic cancer has been vomiting for 18 hours, and compazine is not helping. Could we try some ondansetron, either orally or by subcutaneous infusion?” “What? I've never heard of the drug. Who are you and what business do you have telling me what to do?” Click.“Doctor? This is the hospice nurse taking care of your patient with advanced prostatic cancer. He's taking ms contin, 100 mg every ... Author, Article, and Disclosure InformationAffiliations: The Oberlin Clinic, Inc., Oberlin, OH 44074. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 15 November 1994Volume 121, Issue 10Page: 822-823KeywordsDrugsMorphineNauseaNursesOpioidsPain managementPatientsProstate cancerSedationVomiting ePublished: 15 August 2000 Issue Published: 15 November 1994 Copyright & PermissionsCopyright © 1994 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Exacerbation of left ventricular ischemic diastolic dysfunction by pressure-overload hypertrophy. Modification by specific inhibition of cardiac angiotensin converting enzyme.
Authors: F R Eberli, C S Apstein, S Ngoy, B H Lorell
Journal: Circulation Research (1992)

Hearts with compensatory pressure-overload hypertrophy show an increased intracardiac activation of angiotensin II that may contribute to ischemic diastolic dysfunction. We studied whether pressure-overload hypertrophy in response to aortic banding would result in exaggerated diastolic dysfunction during low-flow ischemia and whether the specific inhibition of the cardiac angiotensin converting enzyme by enalaprilat would modify systolic and diastolic function during ischemia and reperfusion in either hypertrophied or nonhypertrophied hearts. Isolated, red blood cell-perfused isovolumic nonhypertrophied and hypertrophied rat hearts were subjected to enalaprilat (2.5 x 10(-7) M final concentration) infusion during 20 minutes of baseline perfusion and during 30 minutes of low-flow ischemia and 30 minutes of reperfusion. Coronary flow per gram was similar in nonhypertrophied and hypertrophied hearts during baseline perfusion, ischemia, and reperfusion. At baseline, left ventricular developed pressure was higher in hypertrophied than nonhypertrophied hearts in untreated groups (224 +/- 8 versus 150 +/- 9 mm Hg; p less than 0.01) and in enalaprilat-treated groups (223 +/- 9 versus 145 +/- 8 mm Hg; p less than 0.01). During low-flow ischemia, left ventricular developed pressure was depressed but similar in all groups. All groups showed deterioration of diastolic function; however, left ventricular end-diastolic pressure increased to a significantly higher level in untreated hypertrophied than in nonhypertrophied hearts (65 +/- 7 versus 33 +/- 3 mm Hg; p less than 0.001). Enalaprilat had no effect in nonhypertrophied hearts, but it significantly attenuated the greater increase in left ventricular end-diastolic pressure in hypertrophied hearts treated with enalaprilat compared with no drug (65 +/- 7 versus 50 +/- 5 mm Hg; p less than 0.01). The beneficial effect could not be explained by differences in coronary blood flow per gram left ventricular weight, glycolytic flux as reported by lactate production, myocardial water content, oxygen consumption, and tissue levels of glycogen and high energy phosphate compounds. During reperfusion, all hearts showed a partial recovery of developed pressure to 70-74% of initial values. No effect of enalaprilat could be detected during reperfusion on systolic and diastolic function or restoration of tissue levels of high energy compounds. In conclusion, our experiments show that hypertrophied red blood cell-perfused hearts manifest a severe impairment of left ventricular diastolic relaxation in response to low-flow ischemia in comparison with control hearts. Further, our experiments support the hypothesis that the enhanced conversion of angiotensin I to angiotensin II in rats with pressure-overload hypertrophy contributes to the enhanced sensitivity of hypertrophied hearts to diastolic dysfunction during low-flow ischemia.
Induction of angiogenesis by normal and malignant plasma cells
Authors: Dirk Hose, Jérôme Moreaux, Tobias Meissner, Anja Seckinger, Hartmut Goldschmidt, Axel Benner, Karène Mahtouk, Jens Hillengass, Thierry Rème, John De Vos, Michael Hundemer, Maud Condomines, Uta Bertsch, Jean-François Rossi, Anna Jauch, Bernard Klein, Thomas Möhler
Journal: Blood (2009)
The Penetration of Penicillin through Normal and Inflamed Meninges
Authors: J. Murray Kinsman, C. Anthony D'Alonzo
Journal: New England Journal of Medicine (1946)

FOLLOWING the demonstration that penicillin exhibits a remarkable antibacterial effect against organisms frequently causing meningitis, there immediately arose the question of the most effective mode of its administration in patients with these infections. Before penicillin was used in the treatment of meningitis, it was necessary to study its distribution in the body, particularly in the spinal fluid after extrathecal administration. Rammelkamp and Keefer1 demonstrated that the meninges and the choroid plexus form a partial barrier against the passage of the drug from the blood stream into the spinal fluid, both in normal persons and in patients with meningitis. As a . . .
901-1 A Prospective, Randomized Trial Evaluating Early Discharge (Day 3) without Non-invasive Risk Stratification in Low Risk Patients with Acute Myocardial Infarction: PAMI-2
Authors: Bruce Brodie, Cindy L. Grines, Michael Spain, John Griffin, Carlos Balestrini, Gregg W. Stone, Costantino Costantini, Paolo Esente, Michael Ayres, Masakiyo Nobuyoshi, Bryan Donohue, Noah Chelliah, Donald Rothbaum, Thomas Wharton., Denise Jones, Denise Mason, Debra Sachs, William W. O’Neill
Journal: Journal of the American College of Cardiology (1995)
Autoantibody against dihydrolipoamide dehydrogenase, the E3 subunit of the 2-oxoacid dehydrogenase complexes: Significance for primary biliary cirrhosis
Authors: Takashi Maeda, Bruce E. Loveland, Merrill J. Rowley, Ian R. Mackay
Journal: Hepatology (1991)

Autoantibodies in primary biliary cirrhosis recognize mitochondrial 2-oxacid dehydrogenase complexes, particularly the E2 subunits. Reactivity with the E3 subunit, common to each of the enzyme complexes, was sought by immunoblotting, with sera screened at 1:100 instead of the conventional 1:1,000 dilution. This was found in 11 of 29 sera from patients with primary biliary cirrhosis but also in 10 of 40 sera from normal subjects. Two-dimensional immunoblotting and immunoblotting on purified enzymes established that the reactivity was actually with E3 rather than with another component of the 2-oxoacid enzymes of similar molecular weight. Purified antibodies to E3 eluted from an affinity column did not cross-react with other components of the 2-oxoacid enzyme complexes. The antibodies to E3 did not react with the Escherichia coli or yeast E3 subunits, suggesting that they are not stimulated by immune responses against microorganisms. Thus the proposal that reactivity to the shared E3 subunit of the 2-oxoacid enzyme complexes could initiate primary biliary cirrhosis is not reflected at the antibody level. (HEPATOLOGY 1991;14:994–999.)
Potential of Handheld Optical Coherence Tomography to Determine Cause of Infantile Nystagmus in Children by Using Foveal Morphology
Authors: Helena Lee, Viral Sheth, Mashal Bibi, Gail Maconachie, Aarti Patel, Rebecca J. McLean, Michel Michaelides, Mervyn G. Thomas, Frank A. Proudlock, Irene Gottlob
Journal: Ophthalmology (2013)
Abstract 4385: Testosterone induces DNA damage signaling in response to oxidative stress in prostate cancer cells
Authors: Hisamitsu Ide, Yu Jingsong, Lu Yan, Satoru Muto, Shigeo Horie
Journal: Cancer Research (2010)

Abstract Introduction: In prostatic tissues, DNA damage response is specially activated in prostatic intraepithelial neoplasias (PINs) that are generally regarded as precursors of prostate cancer. The process of oncogenic transformation leads to enhanced DNA damage and activates the checkpoint network as an inducible barrier against cancer progression. In this study we analyzed the effects of testosterone under oxidative stress in DNA damage response to understand the biological function and the network of this signaling. Methods: We tested the expression level of PSA and the activation of DNA damage response proteins including ATM (ataxia-telangiectasia-mutated kinase), H2AX (histone H2AX variant) and Chk2 (checkpoint kinase2) in prostate cancer cell lines (LNCaP and PC-3) with various concentration of H2O2. Apoptosis is quantified by flow cytometry and PARP cleavage. Results: H2O2 induces apoptosis and the phosphorylation of ATM, H2AX and Chk2 in LNCaP cells. ATM inhibitor Ku55933 can block the phospholyration of H2AX and Chk2, but induced the activation of alternative pathways, p38 and ERK. Activation of DNA damage response and PARP cleavage was increased by testosterone. H2O2 did not induce phosphorylation of ATM, CHK2 and H2AX in PC-3 cells because of losing their expression. ATM inhibitor Ku55933 can reduce the apoptotic cells in LNCaP cells but PC-3 cells by the treatment of H2O2. Conclusion: Oxidative stress has been associated with tumor formation. On the other hand, DNA damage pathway plays important roles in the maintenance of the cell homeostasis in response to oxidative stress. Our results indicate that androgen signaling have tumor suppressive effects in prostate carcinogenesis through DNA damage response pathways under oxidative stress. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 101st Annual Meeting of the American Association for Cancer Research; 2010 Apr 17-21; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2010;70(8 Suppl):Abstract nr 4385.
743-1 Quantitative Transthoracic Three-dimensional Voxel Imaging of the Left Ventricle: Clinical Validation
Authors: Myung-Yong Lee, Gordon S. Huggins, Leng Jiang, Michael J.A. Williams, Mark D. Handschmacher, Mark S. Adams, Henry Gewirtz, Richard M. Derman, Arthur E. Weyman, Robert A. Levine
Journal: Journal of the American College of Cardiology (1995)
Pulmonary endocrine cells in plexogenic pulmonary arteriopathy associated with cirrhosis.
Authors: J R Gosney, M Resl
Journal: Thorax (1995)

A clear association has been described between numbers of pulmonary endocrine cells and the migration and/or proliferation of myofibroblasts which is thought to underlie the vascular changes seen in plexogenic pulmonary arteriopathy due to cardiac shunts and primary pulmonary hypertension. In contrast, the pulmonary endocrine system in a subject with florid pulmonary plexogenic arteriopathy associated with cirrhosis was entirely normal, suggesting possible differences in its pathogenesis.
INTERFERON GAMMA INDUCES A GREAT IMBALANCE IN MATRIX METALLOPROTEINASE-9/TISSUE INHIBITOR-1 RATIO IN CIRCULATING MONOCYTES FROM CORONARY PATIENTS
Authors: Rafael Boialil, Hector Gonzalez-Pacheco, J. Furazawa, R. Springall, L. Gomez-García, LM Amezcua-Guerra, R. Márquez
Journal: Journal of the American College of Cardiology (2013)
A randomized study of open mitral commissurotomy versus balloon valvuloplasty for selected patients. Immediate and one year follow-up results
Authors: Luiz F. Cardoso, Max Grinberg, Miguel A.N. Rati, Caio C. Medeiros, Flávio Tarasoutchi, Carlos V. Ayres, Pablo M.A. Pomerantzeff, Giovanni M.V. Bellotti
Journal: Journal of the American College of Cardiology (1996)
A dermatosis associated with bacterial overgrowth in jejunal diverticula
Authors: G.M. FAIRRIS, J. ASHWORTH, J.A. COTTERILL
Journal: British Journal of Dermatology (1985)

A patient is described with an unusual skin eruption associated with bacterial overgrowth in jejunal diverticula and malabsorption. The initial skin changes were frankly vasculitic with "target' lesions, whilst older lesions showed a psoriasiform scale and a tendency to central clearing. The illness was associated with raised levels of IgM and IgG containing circulating immune complexes and deposition of IgM and IgG in the dermis. It was suppressed by oral antibiotic therapy. There are similarities between the findings in this patient and those described in the intestinal bypass syndrome.
Scar Tissue, Its Use and Abuse: The Surgical Correction of Deformation Due to Hypertrophic Scar and the Prevention of Its Formation
Authors: Bradford Cannon
Journal: JAMA (1972)

In his<i>Scar Tissue, Its Use and Abuse</i>, Longacre reviews in an interesting fashion the current knowledge about collagen. His associate, Dr. Helen Berry, has contributed two enlightening chapters on the metabolic sequences in wound healing, the biosynthesis of collagen in the recent wound, its realignment and degradation as the wound matures. Of greatest interest to the clinical surgeon is the observation that the predominant normal orientation of collagen fibers is at right angles to the direction of muscle pull. Hypertrophic changes in a scar are caused by major collagen alignment parallel to the muscle pull. Longacre stresses the value of the Z-plasty, singly or multifold, in realigning the molecules of collagen so that they now lie in a direction perpendicular to that of muscle pull. Involution of hypertrophic collagen and reduction in the bulk of the scar tissue results. According to Longacre's evidence, incision through the scar without excision