tbuckley/cabot-search huggingface dataset:
Critical illness due to 2009 A/H1N1 influenza in pregnant and postpartum women: population based cohort study
Authors: I. M. Seppelt, S. Sullivan, Rinaldo Bellomo, D. Ellwood, Simon R. Finfer, B. Howe, M. Knight, C. McArthur, N. McDonnell, C. McLintock, T. J. Morgan, S. Morrison, N. Nguyen
Journal: BMJ (2010)

Participants All women with 2009 H1N1 influenza who were pregnant or recently post partum and admitted to an intensive care unit in Australia or New Zealand between 1 June and 31 August 2009.
Abstract 13291: Left Ventricular Assist Device Support is Associated with Sustained Cardiac CamKII Activation and Increased MEF2
Authors: Estibaliz Castillero, Ruiping Ji, Xiaokan Zhang, Vivian Choi, Ayesha Mannan, Marc Najjar, Halit Yerebakan, Robert Sorabella, Catherine Wang, Yoshifumi Naka, Donna M Mancini, H L Sweeney, Paul C Schulze, Ziad Ali, Isaac George
Journal: Circulation (2014)

Background: Ca2+/calmodulin-dependent protein kinase (CaMK)II has been implicated in impaired myocardial Ca2+ signaling and may play an important role in the development of heart failure (HF). The objective of this study was to characterize CAMKII signaling in patients with HF before and after prolonged left ventricular assist device (LVAD) support. Methods: LV apex tissue pairs were collected in patients with dilated cardiomyopathy (n=10) at LVAD implantation and explantation. Normal cardiac tissue was used as control (n=4). Total protein, as well as cytoplasmic and nuclear fractions, were analyzed by Western Blot analysis. Results: The duration of LVAD support ranged from 48 to 595 days (mean = 271±54) with no patient exhibiting myocardial recovery. Total CamKIIδ levels in failing hearts were significantly higher than normal hearts and increased after LVAD, mainly due to an increase in cytoplasmic CaMKIIδC, which regulates Ca2+ handling (Table 1). Nuclear CaMKIIδB, which regulates Ca2+ gene transcription, did not change. Calmodulin remained increased in the nuclear and cytoplasmic fractions after LVAD. CaMKII autonomous, non-CaM-dependent activity, reflected by phosphorylation in Thr207, was increased pre- and post LVAD in cytoplasmic CaMKIIδC. The CaMKII-dependent myocyte enhancer factor 2 (MEF2) was increased pre- and significantly further post LVAD in the nucleus while decreased in the cytoplasm, suggesting translocation into the nucleus after LVAD support. Class IIa HDACs 4 and 5 interact with MEF2, resulting in repression of MEF2-dependent genes. Phosphorylated levels of HDAC4 and HDAC5 were increased pre- and post LVAD, which would result in activated MEF2. Conclusions: This study shows for the first time an increase of the hypertrophic factor MEF2 associated with persistent activation of CamKIIδC after prolonged LVAD support, which may have implications for cardiac remodeling during mechanical support.
The Evolving Relationship Between the Physician and the Scientist in the 20th CenturyAddressing the Needs of Basic and Clinical Research: Analysis of Graduates of the University of Pennsylvania MD-PhD ProgramBridging the Worlds of Medicine and Science: An Interview With Bert I. Shapiro, MDAnnouncement1999 John Conley Ethics Essay Contest for Medical Students
Authors: E Bromley
Journal: JAMA (1999)
Hormone-Independent In Vitro Erythroid Colony Formation by Bone Marrow Cells From Rauscher Virus-Infected Mice2
Authors: Kees Nooter, Riccardo Ghio
Journal: JNCI Journal of the National Cancer Institute (1975)

Bone marrow cells from BALB/c mice infected with Rauscher erythroblastosis virus produced five to twenty-five times more erythroid colonies in vitro in the absence of erythropoietin (EP) as compared to normal cells. A good correlation existed between the state of the disease and the number of hormone-independent erythroid colony-forming cells (CFU-E). A significant number of hormone-independent CFU-E was found as early as 3 days after infection. A linear relationship existed between the number of cells plated and the number of erythroid colonies formed in vitro. Addition of EP did not enhance colony formation, even at low cell concentrations. Feeder layer experiments demonstrated that EP-independent colony formation was not due to the production of endogenous EP. Repeated injections of phenylhydrazine into normal mice did not lead to the loss of EP responsiveness in vitro; this indicated that the hormone independency induced by the virus was not due to continuous erythropoietic stimulation in vivo. Besides hormone independency, the CFU-E from infected mice required less serum in the culture medium. Normal erythroid colonies regressed after 4 days of culture, but EP-independent colonies from infected mice persisted for more than 2 weeks. These three phenomena may be regarded as indicative for a physiologic transformation.
The fat-derived hormone adiponectin reverses insulin resistance associated with both lipoatrophy and obesity
Authors: T. Yamauchi, J. Kamon, H. Waki, Y. Terauchi, N. Kubota, K. Hara, Y. Mori, T. Ide, K. Murakami, N. Tsuboyama-Kasaoka, O. Ezaki, Y. Akanuma, O. Gavrilova, C. Vinson, M.L. Reitman, H. Kagechika, K. Shudo, M. Yoda, Y. Nakano, K. Tobe, R. Nagai, S. Kimura, M. Tomita, P. Froguel, T. Kadowaki
Journal: Nature Medicine (2001)
Polymorphism in intron 4 of HFE does not compromise haemochromatosis mutation results
Authors: Alison T. Merryweather-Clarke, Jennifer J. Pointon, Jeremy D. Shearman, Kathryn J.H. Robson, Anne Marie Jouanolle, Annick Mosser, Véronique David, Jean-Yves Le Gall, David J. Halsall, Terence S. Elsey, Alison Kelly, Timothy M. Cox, Michael Clare, Adrian Bomford, Jean Luc Vandwalle, Jacques Rochette, Nicolas Borot, Hélène Coppin, Marie-Paule Roth, Eleanor Ryan, John Crowe, Angela Totaro, Paolo Gasparini, Antonella Roetto, Clara Camaschella, Chris Darke, Daniel F. Wallace, Kasra Saeb-Parsy, James S. Dooley, Mark Worwood, Ann P. Walker
Journal: Nature Genetics (1999)
DMSA Renal Scanning versus Urography for Detecting Renal Scars in Vesicoureteral Reflux
Authors: Haluk A. Özen, Ìsmet Basar, Bellas Erbas, Seza Özen, Ali Ergen, Ferhun Balkanci, Mehmet Bakkaloğlu, Ümit Saatci, Aysin Bakkaloğlu
Journal: European Urology (1990)
Addressing Depression and Suicide Among Physician Trainees
Authors: Rida Khan, Jamie S. Lin, Douglas A. Mata
Journal: JAMA Psychiatry (2015)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Psychiatry HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Psychiatry journal
A histopathological study of heterologous transplants of an unusual brain tumor.
Authors: Anderson Nettleship, Wolfgang Zeman
Journal: Cancer Research (1955)

When transplanted into the anterior chamber of the guinea pig eye, an unusual brain tumor displayed invasion and destructiveness to the structure of the eye. It also led to a dispersion of the melanin of the iris. Large amounts of melanin were phagocytosed by the transplanted tumor cells.

In an attempt to classify this tumor, a neuroectodermal growth or a melanomatosis of the meninges could be ruled out. Morphologic alterations of the tumor in the transplants were interpreted as being consistent with a tumor originating from reticuloendothelial elements.
Abstract 10689: Vascular Senescence and Potential Mechanisms for Increased Susceptibility to Cardiovascular Diseases
Authors: Magomed Khaidakov, Xianwei Wang, Sona Mitra, Jawahar L Mehta
Journal: Circulation (2011)

Purpose of the study: Aging is a primary non-modifiable risk factor for cardiovascular diseases including atherosclerosis and hypertension. Several studies have shown complex bi-directional shifts ...
Abstract P108: Habitual Short Sleep Duration Associated with Self-Reported and Objectively-Determined Cardiovascular and Metabolic Disease Risk Factors: Data from NHANES
Authors: Michael A Grandner, Subhajit Chakravorty, Michael Perlis, Linden Oliver, Indira Gurubhagavatula
Journal: Circulation (2014)

Background: Self-reported short and long sleep duration have been associated with adverse cardiometabolic health outcomes in laboratory and epidemiologic studies, but interpretation of such data has been limited by methodological issues. Methods: We analyzed adult 2007-2008 US National Health and Nutrition Examination Survey (NHANES) data (N=5,649). Average self-reported nightly sleep duration was reported and categorized as either very short (&lt;5h), short (5-6h), normal (7-8h), or long (≥9h). Self-reported as well as objective evidence of obesity, diabetes, hypertension, and hyperlipidemia were recorded. Univariate comparisons were conducted across sleep duration categories for all variables. Binary logistic regression analyses were performed using cardiometabolic factor as the outcome variable, and sleep duration category as the predictor variable, before and after adjusting for age, sex, race/ethnicity, acculturation, education, access to insurance, food security, home ownership, smoking, and caffeine use. Results: See table. In adjusted analyses, very short sleep was associated with self-reported hypertension, self-reported hyperlipidemia, objective hyperlipidemia, self-reported diabetes, and objective obesity. Regarding short sleep (5-6hrs), in adjusted analyses, elevated risk was seen for self-reported hypertension self-reported obesity and objective obesity. Regarding long sleep (≥9hrs), no elevated risk was found for any outcomes. Conclusions: Very short and short sleep duration are associated with self-reported and objectively-determined adverse cardiometabolic outcomes, even after adjustment for covariates. Table 1. Unadjusted and Adjusted Odds Ratios (OR) and 95% Confidence Intervals (95%CI) of Associations between Sleep Duration and Cardiometabolic Disease Outcomes *Adjusted analyses include age, sex, race/ethnicity, acculturation, education, insurance, home ownership, food security, smoking, and caffeine
Telephone Psychotherapy and Care Management for Depression
Authors: Samuel Y S Wong
Journal: JAMA (2004)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Poor prognosis of children with pre-B acute lymphoblastic leukemia is associated with the t(1;19)(q23;p13): a Pediatric Oncology Group study
Authors: WM Crist, AJ Carroll, JJ Shuster, FG Behm, M Whitehead, TJ Vietti, AT Look, D Mahoney, A Ragab, DJ Pullen
Journal: Blood (1990)
Histone deacetylases induce angiogenesis by negative regulation of tumor suppressor genes
Authors: Myoung Sook Kim, Ho Jeong Kwon, You Mie Lee, Jin Hyen Baek, Jae-Eun Jang, Sae-Won Lee, Eun-Joung Moon, Hae-Sun Kim, Seok-Ki Lee, Hae Young Chung, Chul Woo Kim, Kyu-Won Kim
Journal: Nature Medicine (2001)
Children's Environmental Health Network, Emeryville, California.
Authors: JE Carlson
Journal: Environmental Health Perspectives (1998)

Research is one of the cornerstones of environmental health, providing the foundation for sound public policy and for appropriate education of communities and professionals in a myriad of disciplines. Until very recently, little research in environmental health focused on exposure patterns and health outcomes for children. Pediatric medicine shows that children are not just little adults; they are uniquely vulnerable.
CODEINE POISONING: FATAL CASE FROM ACCIDENTAL OVERDOSE
Authors: V H CORNELL
Journal: Annals of Internal Medicine (1951)

Case Reports1 May 1951CODEINE POISONING: FATAL CASE FROM ACCIDENTAL OVERDOSEV. H. CORNELL, M.D., F.A.C.P.V. H. CORNELL, M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-34-5-1274 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptCodeine and its salts are so universally used, and poisoning due to these drugs is so rare, that the publication of this case appears warranted. Various authors have been consulted,1, 2, 3, 4, 5, 6, 7and fatal cases are reported as "rare," "not found" or "unknown," though severe symptoms and collapse have occurred after large doses. Cases have recovered after taking approximately 500 to 520 mg., but in such cases immediate therapy or vomiting may have greatly reduced the dose absorbed. Nausea and vomiting are given as frequent and prominent symptoms in codeine poisoning.4Gonzales, Vance and Helperin3give...Bibliography1. PetersonHainesWebster FWSRW: Legal medicine and toxicology, ed. 2, 1926, W. B. Saunders Co., Philadelphia, vol. 2, 546-548. Google Scholar2. Webster RW: Legal medicine and toxicology, 1930, W. B. Saunders Co., Philadelphia, pp. 668-690. Google Scholar3. GonzalesVanceHelperin TAMM: Legal medicine and toxicology, 1937, D. Appleton-Century Co., Inc., New York, pp. 583-584. Google Scholar4. EdmundsGunn CWJA: Cushing's pharmacology and therapeutics, ed. 11, 1936, Lea and Febiger, Philadelphia, p. 396. Google Scholar5. WoodOsol HCA: United States Dispensatory, ed. 23, 1943, J. B. Lippincott Co., Philadelphia, pp. 331-334. Google Scholar6. GoodmanGilman LA: The pharmaceutical basis of therapeutics, 1941, The Macmillan Co., New York, pp. 202-206. Google Scholar7. KruegerEddySumwalt HNBM: The pharmacology of the opium alkaloids, Part 2 (Supplement No. 165 to the Public Health Reports, Federal Security Agency, U.S.P.H.S.), 1943, U. S. Government Printing Office, Washington, pp. 843-844. Google Scholar8. CohenRudolph MBJA: The use and abuse of drugs in asthma, J. A. M. A. 98: 1864-1866, 1932. CrossrefGoogle Scholar9. DrinkerYoffey CKJM: Lymphatics, lymph and lymphoid tissue, 1941, Harvard University Press, Cambridge, Mass., p. 33. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Washington, D. C.*Received for publication May 30, 1949.†Colonel, Medical Corps, U. S. Army; Chief of Laboratory Service, Walter Reed General Hospital, Washington, D. C. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 May 1951Volume 34, Issue 5Page: 1274-1277KeywordsCodeineDrugsNauseaResearch laboratoriesSaltsVomiting ePublished: 1 December 2008 Issue Published: 1 May 1951 PDF downloadLoading ...
A memorable patient: A surprising diagnosis
Authors: C. Harkness
Journal: BMJ (2000)

meningococci, and typically less than 1% even in outbreaks, 12 14 17 our study found serogroup carriage rates of 3% by December.This level increases the risk of outbreaks.Serogroup C disease is of particular importance as it is preventable by vaccine and has previously been linked to large clusters of disease among university students. 5 6 The large comparative increase in the C:2a:P1.5 (P1.2) strains is noteworthy.This strain is known to be virulent and has been implicated in several major outbreaks 3 5 6 ; it represented 6.3% of all acquired strains in our study but only 1% of index strains identified in October.This illustrates the ability of highly virulent clones to transmit readily among students.Indeed the preferential transmission of this strain from a low baseline carriage rate may explain the 3-5 week delay usually observed between the start of university term and the peak incidence of cases and outbreaks.During the beginning of university terms there is a rapid spread of meningococci in first year students, which is probably associated with social mixing, especially in catered halls.Our findings support the recent introduction of meningococcal vaccination for university students.
Endobronchial ultrasonography detects subepithelial remodeling in large airways of asthmatic horses
Authors: Michela Bullone, Mireille Godbout, James G. Martin, Jean-Pierre Lavoie
Journal: European Respiratory Journal (2014)

Heaves is a naturally-occurring asthma-like disease of horses. Increased smooth muscle (ASM) and extracellular matrix (ECM) mass have been detected in airways of asthmatic man and horses. Assessment of ASM and ECM remodeling in vivo is still problematic, as endobronchial biopsies often provide incomplete sampling of the bronchial wall. Endobronchial ultrasonography (EBUS) allows non-invasive evaluation of large airway structures in man and in isolated equine lungs, as we have already shown ex vivo .We now hypothesize that in vivo EBUS can differentiate horses with heaves from controls based on the thickness of ASM and ECM layer.

EBUS was performed in 4 horses with heaves and 3 controls under sedation using a 30 MHz radial probe. Horses were then humanely euthanized for reasons other than respiratory conditions. Ten randomly chosen cartilaginous bronchi were harvested at necropsy from the lungs of all animals and processed for histology. Internal airway perimeter (Pi), thickness of the epithelium (L1), combined ECM and ASM layers (L2) and L2 area were measured on EBUS images. The equivalent structures were measured on histological sections.

A significant increase in L2 thickness and normalized L2 area (AL2/Pi2) were detected in central airways of horses with heaves compared to controls (p<0.05). Results were confirmed histologically as ASM mass and ECM components were increased in the large airways of heaves-affected horses compared to controls (p<0.05). Therefore, EBUS allows in vivo evaluation of bronchial remodeling affecting large airway submucosal structures in horses and could be used to monitor airway remodeling non-invasively in interventional studies in this species.
Thermal Dosimetry Session: Summary of Discussion
Authors: Thomas C. Cetas
Journal: Cancer Research (1984)

The purpose of this session was to discuss various concepts relating to thermal dosimetry. The first paper, presented by M. W. Dewhirst, explained how a particular thermal dose unit can be used to predict response in vivo in real-life clinical tumors. The second paper by J. W. Strohbehn discussed power depo sition and temperature distributions to be expected from certain power deposition patterns. R. B. Roemer presented the third paper concerning heat transfer models, and the fourth paper by P. Fessenden discussed temperature measurements within the clinic. The final paper, by T. C. Cetas, was speculative and presented other approaches to thermometry and, in particular, dealt with the issue of thermal tomography. Following the first paper, W. C. Dewey asked if the complica tions of thermal infarcts following therapy were a consequence of high temperature in the tumor or high normal tissue temper atures near the tumor. Dewhirst replied that the correlation was with very high tumor temperatures, and the infarcts probably resulted from damage to the microcirculation and in the release of local toxins by the tumor as a consequence of therapy. While his thermal dosimetry was not perfect, the impression was that the temperatures of the normal tissue were not excessive. B. Emami asked if the difference in response rates for radiofrequency heating and microwave heating was due to fundamen tal differences. Dewhirst replied that, in general, he was able to heat tumors more uniformly with the radiofrequency system than with the microwave system and, hence, was less likely to have cold spots and, therefore, a poor response. G. H. Nussbaum raised the issue of where the temperatures were measured within the tumor. Dewhirst replied that the thermometers were placed in a regular pattern, and temperatures were measured in each tumor. Specific locations selected thus became a problem in statistical sampling. He gave the analogy of walking into an alfalfa field and randomly selecting samples of plants. A search for a specific specimen is not made but, rather, one accepts what is given from a random sample and then attempts to generalize based upon the random sample. Following Strohbehn's lecture, there was substantial discus
Critical Outcomes in Nonrobotic vs Robotic-Assisted Cardiac Surgery
Authors: Franz Yanagawa, Martin Perez, Ted Bell, Rod Grim, Jennifer Martin, Vanita Ahuja
Journal: JAMA Surgery (2015)

As robotic-assisted cardiac surgical procedures increase nationwide, surgeons need to be educated on the safety of the new modality compared with that of open technique.To compare complications, length of stay (LOS), actual cost, and mortality between nonrobotic and robotic-assisted cardiac surgical procedures.Weighted data on cardiac patients who had undergone operations involving the valves or septa and vessels, as well as other heart and pericardium procedures, from January 1, 2008, to December 31, 2011, were obtained from the Nationwide Inpatient Sample via the Healthcare Cost and Utilization Project of the Agency for Healthcare Research and Quality. Propensity score matching was used to match each robotic-assisted case to 2 nonrobotic cases on 14 characteristics.Complications, median LOS, actual cost, and mortality.Exploratory analysis found a total of 1,374,653 cardiac cases (1,369,454 [99.6%] nonrobotic and 5199 [0.4%] robotic-assisted cases). After propensity score matching, there were 10,331 (66.5%) nonrobotic cases and 5199 (33.5%) robotic-assisted cases. Cardiac operations included 1630 (10.5%) involving the valves or septa, 6616 (42.6%) involving the vessels, and 7284 (46.9%) other heart and pericardium procedures. Robotic-assisted compared with nonrobotic surgery had a higher median cost ($39,030 vs $36,340; P < .001) but lower LOS (5 vs 6 days; P < .001) and lower mortality (1.0% vs 1.9%; P < .001). Robotic-assisted surgery had significantly fewer complications for all operation types (30.3% vs 27.2%; P < .001).Overall, robotic-assisted surgery has significantly reduced median LOS, complications, and mortality compared with nonrobotic surgery. Results of this study support the contention that robotic-assisted surgery is as safe as nonrobotic surgery and offers the surgeon an additional technique for performing cardiac surgery.