tbuckley/cabot-search huggingface dataset:
Abstract 4448: Clopidogrel Effect Depends on Body Weight and Abolishes Platelet Leukocyte Interaction in Patients with Coronary Artery Disease Treated by Stenting
Authors: Philipp Diehl, Christoph Olivier, Christoph Halscheid, Thomas Helbing, Christoph Bode, Martin Moser
Journal: Circulation (2008)

Background: Poor response to aspirin and clopidogrel has been associated with an increased risk for thrombotic events after PCI. The optimal dose of clopidogrel is unknown as platelet aggregability (PA) is not routinely measured in clopidogrel treated patients. Methods and Results : In order to assess potential mechanisms of clopidogrel responsiveness we have performed bedside platelet impedance aggregometry in patients with stable coronary artery disease (group CAD; n=62) and patients who underwent elective PCI (group PCI; n=90) compared to control individuals in whom coronary artery disease was excluded by coronary angiography (group control; n=28). Control patients did not receive antiplatelet therapy, CAD patients were treated with aspirin 100mg/d, and PCI patients with aspirin 100mg/d and clopidogrel 75mg/d. Impedance aggregometry was performed using arachidonic acid [AA] (final conc [fc]: 0.5mM) or ADP (fc: 6.5μM) and the area under the curve (AUC) was quantified to detect the effect of aspirin or clopidogrel, respectively. Indeed, PA was specifically reduced by either drug (AA: [control vs. CAD vs. PCI] 877±300 vs. 183±134 vs. 111±90; ADP: [control vs. PCI] 725±275 vs. 288±174 AUC). We detected a negative correlation between body weight and clopidogrel response (r=0.28; p=0.008), suggesting that clopidogrel may have been underdosed in obese patients. Furthermore, we found a positive correlation between leukocyte counts and PA (r=0.4, p=0.028) confirming that platelets and leucocytes interact functionally. Administration of clopidogrel abolished this interaction as detected by comparison of control individuals with PCI patients but also in intra-individual follow-up tests before and after introduction of clopidogrel. Conclusion: Impedance aggregometry is useful to assess PA routinely. Dosage of clopidogrel may need to be adjusted in obese patients. PA depends on leukocyte counts confirming that platelet activity is modulated by leukocytes; this interaction is effectively inhibited by clopidogrel.
Abstract 990: Long-term Treatment With Resveratrol Restores Streptozotocin Induced Decline In Cardiac Function and Sarcoplasmic Reticulum Calcium ATPase Expression
Authors: Mohamed Sulaiman, Mahesh P Gupta, Madhu Gupta
Journal: Circulation (2007)

Background: Diabetic cardiomyopathy, characterized by impaired cardiac contractility, develops independent of vascular disease. An important contributor to diastolic dysfunction in the diabetic hea...
Advances in Cancer Research. Vol 7.
Authors: G. Klein, S. Weinhouse
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Organic Food Consumption during Pregnancy and Hypospadias and Cryptorchidism at Birth: The Norwegian Mother and Child Cohort Study (MoBa)
Authors: Anne Lise Brantsæter, Hanne Torjusen, Helle Margrete Meltzer, Eleni Papadopoulou, Jane A. Hoppin, Jan Alexander, Geir Lieblein, Gun Roos, Jon Magne Holten, Jackie Swartz, Margaretha Haugen
Journal: Environmental Health Perspectives (2015)

The etiologies of the male urogenital anomalies hypospadias and cryptorchidism remain unclear. It has been suggested that maternal diet and environmental contaminants may affect the risk of these anomalies via placental or hormonal disturbances.We examined associations between organic food consumption during pregnancy and prevalence of hypospadias and cryptorchidism at birth.Our study includes 35,107 women participating in the Norwegian Mother and Child Cohort Study (MoBa) who delivered a singleton male infant. Information about use of six groups of organically produced food (vegetables, fruit, bread/cereal, milk/dairy products, eggs, and meat) during pregnancy was collected by a food frequency questionnaire. Women who indicated that they sometimes, often, or mostly consumed organic foods in at least one of the six food groups were classified as organic food consumers in analyses. Hypospadias and cryptorchidism diagnoses were retrieved from the Medical Birth Registry of Norway. We estimated odds ratios (ORs) and 95% confidence intervals (CIs) using multiple logistic regression.Seventy-four male newborns were diagnosed with hypospadias (0.2%), and 151 with cryptorchidism (0.4%). Women who consumed any organic food during pregnancy were less likely to give birth to a boy with hypospadias (OR = 0.42; 95% CI: 0.25, 0.70, based on 21 exposed cases) than women who reported they never or seldom consumed organic food. Associations with specific organic foods were strongest for vegetable (OR = 0.36; 95% CI: 0.15, 0.85; 10 exposed cases) and milk/dairy (OR = 0.43; 95% CI: 0.17, 1.07; 7 exposed cases) consumption. No substantial association was observed for consumption of organic food and cryptorchidism.Consumption of organically produced foods during pregnancy was associated with a lower prevalence of hypospadias in our study population. These findings were based on small numbers of cases and require replication in other study populations.
针吸细胞学检查在癌症诊断中的应用——如果应用恰当，仍不失为一种快速、廉价和准确的诊断方法
Authors: DerekERoskell, 崔瑷, 代华平
Journal: BMJ (2005)

针吸细胞学(FNAC)检查是指应用细针(22-25G)收集病变处组织学标本并行显微镜检查的技术。这是一种损伤小而快速的诊断方法，但是由于不能显示组织结构，而使某些病例不能确定诊断。与所有侵入性检查一样，这种检查方法也有一定的风险和漏诊、误诊率。由于假阴性结果和偶尔出现的并发症，一度使人们认为这种技术是“无效和危险的”。但是如果要放弃针吸活检这种检查方法，
Abstract 21572: Spectrum and Prevalence of Mutations Involving the Known Brugada Syndrome-Susceptibility Genes in a Large Cohort of Unrelated Patients with Clinically Diagnosed Brugada Syndrome
Authors: Lia Crotti, David J Tester, Argelia Medeiros-Domingo, Alessandra Cuoretti, John R Giudicessi, Peter J Schwartz, Michael J Ackerman
Journal: Circulation (2010)

Background: Brugada syndrome (BrS) is a heritable arrhythmia syndrome characterized by an ECG pattern of coved type ST-segment elevation in the right precordial leads (V1 through V3) and an increas...
Abstract 2569: The SCN5A Mutation R680H From Sudden Death Interacts With a Polymorphism SCN5A-S1103Y Common in African Americans to Increase Late Sodium Current
Authors: Jianding Cheng, David J. Tester, Bi-Hua Tan, Carmen Valdivia, Stacie Kroboth, Bin Ye, Craig T. January, Michael J. Ackerman, Jonathan C. Makielski
Journal: Circulation (2009)

Background- The common polymorphism SCN5A-S1103Y (~13% allelic frequency in African Americans) has been implicated as a risk factor for arrhythmia, sudden unexplained death (SUD), and sudden infant...
Pharmacological properties of the PI3 kinase (PI3K) inhibitors PI-540 and PI-620
Authors: Florence Raynaud, Angela Hayes, Francesca Di Stefano, Paul Clarke, Melanie Valenti, Zahida Ahmad, Sue Eccles, Adrian Folkes, Nahid Saghir, Anthony Robson, Stephen Shuttleworth, Paul Workman
Journal: Cancer Research (2008)

AACR Annual Meeting-- Apr 12-16, 2008; San Diego, CA

LB-149 

The PI3K pathway is highly deregulated in cancer and has been the focus of much drug discovery effort in the last decade. We have previously reported the pyridofuropyrimidine PI-103 as a potent inhibitor of p110α, p110β and p110δ(1). PI-103 inhibits cancer cell proliferation consistent with pathway modulation but has pharmaceutical limitations such as poor solubility and significant metabolism in liver microsomal incubations. Here we report the improved pharmacological properties of the thienopyrimidine PI3K inhibitors. PI-540 and PI-620 that show a similar in vitro profile to that of PI-103. Submicromolar efficacy was observed in U87MG glioblastoma cells, PC3 prostate carcinoma, Detroit 562 squamous cell carcinoma , IGROV-1 ovarian carcinoma and human endothelial cells (HUVEC). In the human glioblastoma U87MG, all 3 compounds showed similar pathway modulation in the multiplexed electroluminescent immunoassay (Mesoscale Discovery; see Table).        PI-540 and PI-620 showed improved solubility (>100μM) when compared with PI-103 ( 30 for PI-540 and PI-620; compared to 1 for PI-103. PI-540 and PI-620 showed significant antitumour efficacy in the U87MG glioblastoma and SKOV3 ovarian carcinoma xenograft models with T/C of 66 and 60 for PI-540 at 100mg/kg uid and PI-620 at 25mg/kg bid respectively. In addition to growth inhibition in vitro and in vivo, a significant antiangiogenic effect was observed. This series of PI3K inhibitors shows considerable potential for cancer treatment. This work was funded by Cancer Research UK and by Piramed Ltd.    1. Raynaud et al., Cancer Research 67;12:5840, 2007.

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Abstract 14250: Incidence of Provoked Exercise Desaturation in Patent Foramen Ovale and Impact of Percutaneous Closure
Authors: Ganesh Devendra, Ajinkya Rane, Stephen A Hart, Richard Krasuski
Journal: Circulation (2011)

Introduction: Platypnea-orthodeoxia is a well described but uncommon phenomenon in patients with patent foramen ovale (PFO). In PFO patients with dyspnea, however, we have more commonly witnessed o...
Influence of pregnancy on breast cancer tumor characteristics and mortality in Iowa women
Authors: C. E. Scott-Conner, P. A. Romitti, C. F. Lynch, N. Wilkinson, G. Lal, L. Zhou, B. J. Smith
Journal: Journal of Clinical Oncology (2006)

584 Background: Hormonal factors such as pregnancy influence development and course of breast cancer. We identified women who became pregnant during the preclinical phase or shortly after diagnosis of breast cancer, compared them with similar women who had not been pregnant in that time period, and studied tumor characteristics and mortality. Methods: Birth and fetal death certificates were linked with Iowa Cancer Registry information for 10,624 women ≤50 years of age diagnosed with breast cancer as a first invasive primary between January 1, 1975 and December 31, 2002. Women who were pregnant two years before (n=160) or after diagnosis of breast cancer (n=53)and those who had not been pregnant (NP) (n=5008) were identified using probabilistic computer matching with manual review confirmation. Clinical, pathological and 10-year survival data were compared between these groups. Preliminary analysis revealed similarities between women who were pregnant before and after diagnosis. These were combined for analysis (P). Results: The study subjects distributed themselves across two SEER stages of disease: 1) localized, and 2) locally advanced or regional nodal disease (LABC). SEER stage (50% LABC vs. 39% LABC) and grade (75% high grade vs. 56% high grade) were higher in P than in NP cases. Ten-year survival for localized disease was 0.766 (95% CI 0.649–0.848) for P and 0.874 (95% CI 0.858–0.888) for NP (log rank test p= 0.0178). Ten-year survival for LABC was 0.520 (95% CI 0.373–0.649) for P and 0.629 (95% CI 0.601–0.655) for NP (log rank test p= 0.0234). Multivariate analysis ( table below) showed an adverse effect of pregnancy status on survival, independent of stage, grade, age or progesterone receptor (PR) status. Conclusions: Women who are pregnant within two years of diagnosis of breast cancer have higher grade, more locally-advanced tumors and experience a higher mortality than similar women who are never pregnant. Pregnancy persists as a significant adverse survival variable after adjustment for age, grade, stage, and PR status. [Table: see text] No significant financial relationships to disclose.
Abstract 5558: Growth inhibitory effect of perganum, sage, and olive leaves plant extracts on breast and lung cancer cell lines
Authors: Carla Gibbs, Ola Almusallam, Trent E. Malone, Elbert L. Myles
Journal: Cancer Research (2015)

Abstract There are many different types of cancer, and generally each is defined by the type of cell that is affected. Cancer occurs in cells by which mutant genes are responsible for cell growth. This may result in metastasis which may affect one or more parts of the body. The current student attempts to address cancer treatment from Natural product sources. Sage leaves (Salvia officanlis), Perganum leaves (harmala), and Olive leaves (Olea europaea) were used in this study to determine their effects on two cancer cell lines, A549 and MCF-7. Our findings revealed that Salvia officanlis, Perganum harmala, and Olea europaea have significant effect on both cell lines (MCF-7 Brest cancer cell line and A549 lung cancer cell line). Salvia officanlis leaf extracts had a greater effect on MCF-7 and A549 than Perganum harmala and Olea europaea. Salvia Officanlis demonstrated a significantly decreased the growth rate and cell survival of both cancer cell lines at all concentrations. In future studies, Salvia officanlis, Perganum harmala, and Olea europaea act with MCF-7 Brest cancer cell line and A549 lung cancer cell line to inhibit their growth Citation Format: Carla Gibbs, Ola Almusallam, Trent E. Malone, Elbert L. Myles. Growth inhibitory effect of perganum, sage, and olive leaves plant extracts on breast and lung cancer cell lines. [abstract]. In: Proceedings of the 106th Annual Meeting of the American Association for Cancer Research; 2015 Apr 18-22; Philadelphia, PA. Philadelphia (PA): AACR; Cancer Res 2015;75(15 Suppl):Abstract nr 5558. doi:10.1158/1538-7445.AM2015-5558
Abstract 18368: Role of miR-146a in Angiogenesis and Myocardial Regeneration
Authors: Rebecca Widmer-Teske, Kai Kueppers, Wiebke Bielenberg, Jan-Marcus Daniel, Christian Troidl, Holger Nef, Christian Hamm, Daniel Sedding
Journal: Circulation (2012)

Background Myocardial infarction leads to cardiac remodeling and development of heart failure. Myocardial remodeling and regeneration critically depends on myocardial capillary density after myocardial infarction. However, the underlying mechanisms of myocardial angiogenesis are not well understood. Methods and Results Here, we show that the small noncoding RNA microRNA-146a (miR-146a) is upregulated in ischemic cardiac regions in C57Bl-6 mice following LAD-ligation. In vitro, overexpression of miR-146a significantly attenuates endothelial cell proliferation and migration, abolishes endothelial capillary network formation on Matrigel, and inhibits cell sprouting from endothelial spheroids. In contrast, knock-down of miR-146a significantly augments endothelial cell proliferation, migration, network formation and sprouting. So far, IRAK1 and TRAF6, were identified by in silico predictive approaches as direct targets of miR-146a and validated by reciprocal regulation on mRNA and protein levels as well as luciferase gene reporter assays in endothelial cells. In vivo, blocking of endothelial miR-146a significantly enhances angiogenesis as determined by matrigel plug assays. Moreover, inhibition of miR-146a by systemic application of specific antagomirs enhances myocardial vascularity and limits myocardial infarct size in mice, which results in preserved cardiac function (FS: 22±4 vs. 11±2; n=6; P&lt;0.01). Conclusions Our findings indicate that miR-146a acts as a critical regulator of endothelial cell angiogenesis during myocardial regeneration. Moreover, miR-146a may represent an attractive target for future therapeutic interventions for the treatment of ischemic heart disease.
Abstract 1361: M-T7, A Viral Chemokine Modulating Protein (vCMP) Inhibits Plaque Growth Through Interruption of Chemokine: GAG Interactions
Authors: Erbin Dai, Liying Liu, Kasinath Viswanathan, Ganesh Munuswamy Ramanujam, Colin Macauley, Xing Li, Jeffrey D Esko, Israel F Charo, Grant McFadden, Alexandra Lucas
Journal: Circulation (2006)

Background: Transplant vasculopathy impedes long-term organ transplant survival. Early inflammatory cell invasion initiates progressive neointimal hyperplasia and vessel occlusion, termed chronic r...
Expression of Human Inducible Nitric Oxide Synthase Gene in T-Cell Lines Infected With Human T-Cell Leukemia Virus Type-I and Primary Adult T-Cell Leukemia Cells
Authors: Naoki Mori, Youichi Nunokawa, Yasuaki Yamada, Shuichi Ikeda, Masao Tomonaga, Naoki Yamamoto
Journal: Blood (1999)
Benefits of Neuronal Preferential Systemic Gene Therapy for Neurotransmitter Deficiency
Authors: Ni-Chung Lee, Shin-Ichi Muramatsu, Yin-Hsiu Chien, Wen-Shin Liu, Wei-Hua Wang, Chia-Hao Cheng, Meng-Kai Hu, Pin-Wen Chen, Kai-Yuan Tzen, Barry J Byrne, Wuh-Liang Hwu
Journal: Molecular Therapy (2015)

Aromatic L-amino acid decarboxylase (AADC) deficiency is a rare autosomal recessive disease that impairs synthesis of dopamine and serotonin. Children with AADC deficiency exhibit severe motor, behavioral, and autonomic dysfunctions. We previously generated an IVS6+4A>T knock-in mouse model of AADC deficiency (DdcKI mice) and showed that gene therapy at the neonatal stage can rescue this phenotype. In the present study, we extended this treatment to systemic therapy on young mice. After intraperitoneal injection of AADC viral vectors into 7-day-old DdcKI mice, the treated mice exhibited improvements in weight gain, survival, motor function, autonomic function, and behavior. The yfAAV9/3-Syn-I-mAADC-treated mice showed greater neuronal transduction and higher brain dopamine levels than AAV9-CMV-hAADC-treated mice, whereas AAV9-CMV-hAADC-treated mice exhibited hyperactivity. Therefore, neurotransmitter-deficient animals can be rescued at a young age using systemic gene therapy, although a vector for preferential neuronal expression may be necessary to avoid hyperactivity caused by this treatment. Aromatic L-amino acid decarboxylase (AADC) deficiency is a rare autosomal recessive disease that impairs synthesis of dopamine and serotonin. Children with AADC deficiency exhibit severe motor, behavioral, and autonomic dysfunctions. We previously generated an IVS6+4A>T knock-in mouse model of AADC deficiency (DdcKI mice) and showed that gene therapy at the neonatal stage can rescue this phenotype. In the present study, we extended this treatment to systemic therapy on young mice. After intraperitoneal injection of AADC viral vectors into 7-day-old DdcKI mice, the treated mice exhibited improvements in weight gain, survival, motor function, autonomic function, and behavior. The yfAAV9/3-Syn-I-mAADC-treated mice showed greater neuronal transduction and higher brain dopamine levels than AAV9-CMV-hAADC-treated mice, whereas AAV9-CMV-hAADC-treated mice exhibited hyperactivity. Therefore, neurotransmitter-deficient animals can be rescued at a young age using systemic gene therapy, although a vector for preferential neuronal expression may be necessary to avoid hyperactivity caused by this treatment.
Would Be Cyclophosphamide, Thalidomide and Dexamethasone (CTD) a Possible Treatment For Multiple Myeloma Where Is Not Possible New Drugs?
Authors: Marcelo Bellesso, Marcela Cavalcante de Andrade Silva, Rodrigo Dolphini Velasques, Helena Visnadi, Roberta Shcolnik, Fernanda Salles Seguro, Debora Levy, Andre Neder Ramires Abdo, Rodrigo Santucci, Juliana Pereira, Gracia Aparecida Martinez
Journal: Blood (2013)
Abstract 16805: Early Short-Term Unloading with Left Ventricular Assist Device Prevents Remodeling, Reduces Regional Hypertrophy After Myocardial Infarction via Multiple Pathways
Authors: Xufeng wei, Tieluo Li, Katrina Williams, Pei Zhang, Giacomo Bianchi, HoSung Son, Shuying Li, Zhongjun Wu, Bartley P Griffith
Journal: Circulation (2011)

Introduction Left ventricular assist device (LVAD) has garnered great interest recently for its remodeling reversal of end-stage heart failure (HF). However, recovery sufficient to permit device removal is low, with relatively high incidence of early HF recurrence. In the present study, we utilized early intervention and placement of a minimally-invasive axial LVAD post-MI to prevent cardiac remodeling after MI. Methods Eighteen sheep were used in the study. Six sheep underwent an apical MI and were unloaded with an axial LVAD in first 2 weeks and terminated at 12 weeks. Eight sheep with MI and Four sham sheep were used as control. Sixteen sonomicrometry transducers were implanted to record the deformation of the end-diastolic LV geometry (diastolic strain). Global hypertrophy was evaluated by mass index. Regional hypertrophy in non-ischemic adjacent zone (AZ) and remote zone (RZ) of MI were evaluated by thickness of free wall of the LV and cardiomyocyte size. Three pro-hypertrophic pathways, PI3K/Akt/GSK-3β, Calcineurin/NFAT, Raf/MEK/ERK1/2 pathway were investigated regionally. Results LV dilation and dysfunction post MI were mitigated in the MI+LVAD group (LVEDV: 85.9±7.3 ml vs 106.1±14.3 ml; EF: 44.9±1.7% vs 39.4±2.4%, P&lt;0.05). Adjacent zone strain was exacerbated in the MI group, whereas MI+LVAD group strain was ameliorated in comparison. Regional hypertrophy was evident in adjacent zone compared with in remote zone in the MI group (thickness of the wall: 0.96±0.13cm vs 0.71±0.22cm; the increase of cardiomyocyte size: 76.2±6.1% vs 14.5±3.5%, P&lt;0.05). There was no significant regional hypertrophy in the MI+LVAD group. All the three mechanical stress related hypertrophic pathways were activated in the adjacent zone in MI group but not in MI+LVAD group as shown in table 1. Conclusions Early short-term LVAD unloading could prevent cardiac remodeling; reduce regional hypertrophy after MI through inhibiting the activation of multiple hypertrophic pathways.
Exposure to Lead: Sources and Effects
Authors: T. Konno, H. Suzuki, T. Kutsuzawa, A. Imai, N. Katsushima, M. Sakamoto, S. Kitaoka
Journal: New England Journal of Medicine (1977)

Some topics discussed are as follows: increased vulnerability of young children to lead; effects of lead on chemistry of blood; effects of lead on globin and collagen synthesis; toxicity of lead to brain of children; association of lead exposure with poverty; effects of lead exposure during pregnancy; sources of lead such as paint, dust, automobile emissions, food, water, ceramic tableware, and glazes on exterior of glasses; and relative contribution of each source. (HLW)