OBSERVATIONS ON THE INFLUENCE OF MEDICAL THERAPY ON PORTAL HYPERTENSION IN HEPATIC CIRRHOSIS
Authors: C M LEEVY, M ZINKE, J BABER, W Y CHEY
Journal: Annals of Internal Medicine (1958)

Article1 October 1958OBSERVATIONS ON THE INFLUENCE OF MEDICAL THERAPY ON PORTAL HYPERTENSION IN HEPATIC CIRRHOSISCARROLL M. LEEVY, M.D., F.A.C.P., MYRA ZINKE, M.D., JULIUS BABER, M.D., WOO YOON CHEY, M.D.CARROLL M. LEEVY, M.D., F.A.C.P.Search for more papers by this author, MYRA ZINKE, M.D.Search for more papers by this author, JULIUS BABER, M.D.Search for more papers by this author, WOO YOON CHEY, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-49-4-837 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptChoice of medical or surgical therapy for portal hypertension and its manifestations in cirrhosis has been the subject of considerable debate. Proponents for surgical therapy feel that portal hypertension is usually due to irreversible factors and requires operative intervention;1-3 others believe reversible morphologic and functional alterations contribute to an elevated portal pressure, and advise prolonged medical management.4-7Improved technics for the study of hepatic circulation in man have provided greater objectivity in evaluating response to medical therapy. Portal pressure may be measured indirectly by wedged hepatic vein catheterization,7-14percutaneous splenic puncture15, 16and transesophageal manometric recordings.17These studies, coupled with...Bibliography1. Blakemore AH: The portacaval shunt for portal hypertension with special reference to cirrhosis of the liver, Bull. New York Acad. Med. 27: 477, 1951. MedlineGoogle Scholar2. MaddenLoreGeroldRavid JLJMFPJM: The pathogenesis of ascites and a consideration of its treatment, Surg., Gynec. and Obst. 99: 385, 1954. MedlineGoogle Scholar3. 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JohnsonConn RDJW: Aldosterone, antidiuretic hormone and congestive heart failure, Mod. Concepts Cardiovas. Dis. 27: 431, 1957. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Jersey City, New Jersey*Presented at the Thirty-ninth Annual Session of The American College of Physicians, Atlantic City, New Jersey, May 1, 1958.From the Hepatic Metabolic Research Unit, Jersey City Medical Center and Seton Hall College of Medicine.†Supported in part by grants from the Division of Chronic Illness Control, New Jersey State Department of Health, Chas. Pfizer & Co., Inc., and The Upjohn Co.‡Trainee, National Institutes of Health.§Fellow in Metabolism and Gastroenterology.Requests for reprints should be addressed to Carroll M. Leevy, M.D., Department of Medicine, Medical Center, Jersey City, New Jersey. 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THOMPSON, M.D., F.A.C.P.A Comparison of the Radiologic and Esophagoscopic Diagnosis of Esophageal VaricesSpontaneous Decrease in Portal Pressure with Clinical Improvement in CirrhosisIncreased Abdominothoracic Venous Pressure Gradients in Patients with Cirrhosis of the LiverPortal Hypertension 1 October 1958Volume 49, Issue 4Page: 837-851KeywordsCirrhosisHypertensionInflammationNecrosisPeptic ulcersPortal hypertensionProteinsRegenerative medicineThrombosisVeins ePublished: 1 December 2008 Issue Published: 1 October 1958 PDF downloadLoading ...