tbuckley/cabot-search huggingface dataset:
THE PIGMENT OF COMEDONES
Authors: CICELY BLAIR, C. A. LEWIS
Journal: British Journal of Dermatology (1970)

SUMMARY.— The predominant pigment of the comedo appears to be melanin. The darkness of the tips of comedones, apparent in vivo, has been confirmed by examination of expressed comedones with the dissecting microscope. Histochemical techniques, applied to comedones from many different sources, confirm that the dark tip results from melanin granules within the horny cells which form the foundations of the comedo and which are more tightly packed toward the tip; the granules, which are visible with the light microscope can be blackened or bleached by methods appropriate for melanin. The amount of pigment within the comedo and of melanin staining parallels the intensity of general skin pigmentation of the donor, is absent from albino comedones and very dark in specimens from Negro skin. Extraneous pigments including carbon and metallic particles have been found in some comedones. The source and significance of the pigments found is discussed.
What do we know about benefits ofH. pyloritreatment in childhood?
Authors: Mónica S Sierra, Emily V Hastings, Karen J Goodman
Journal: Gut Microbes (2013)

Policy analysis shows that H. pylori test and treat strategies targeting adults at moderate to high risk of H. pylori-induced disease is likely to be cost-effective for preventing digestive diseases responsible for a large global disease burden. Little is known, however, about health benefits to children from eliminating this infection. We conducted a systematic review of the evidence regarding health benefits to children from treatment to eliminate H. pylori infection. We systematically searched Ovid MEDLINE for pertinent review articles published through 2012. We excluded reviews focused on treatment efficacy and scrutinized reference lists of selected reviews to identify additional eligible reviews. Fifteen reviews met specified inclusion criteria. Overall, they show that few reported studies investigating pediatric health effects of treatment for H. pylori infection were well designed with adequate statistical power. Thus, there is insufficient evidence for drawing conclusions about health benefits to children from treatment to eliminate H. pylori infection.
Multidrug Resistance Proteins Do Not Predict Benefit of Adjuvant Chemotherapy in Patients with Completely Resected Non–Small Cell Lung Cancer: International Adjuvant Lung Cancer Trial Biologic Program
Authors: Martin Filipits, Vincent Haddad, Katharina Schmid, Anh Huynh, Ariane Dunant, Fabrice André, Elisabeth Brambilla, Rolf Stahel, Jean-Pierre Pignon, Jean-Charles Soria, Helmut H. Popper, Thierry Le Chevalier, Robert Pirker
Journal: Clinical Cancer Research (2007)

Abstract Purpose: The purpose of our study was to determine whether multidrug resistance proteins (MRP) are of prognostic and/or predictive value in patients who were enrolled into the International Adjuvant Lung Cancer Trial (IALT). Experimental Design: Expression of MRP1 and MRP2 was immunohistochemically assessed in tumor specimens obtained from 782 IALT patients. Prognostic and predictive analyses were based on Cox models adjusted for clinical and pathologic variables. Results: MRP1 expression was considered positive in 364 (47%) patients and MRP2 expression in 313 (40%) patients. MRP2-positive patients had a significantly shorter overall survival than MRP2-negative patients in the total patient population [adjusted hazard ratio for death, 1.37; 95% confidence interval (95% CI), 1.09-1.72; P = 0.007]. There was no significant association between MRP1 expression and overall survival. Neither MRP1 nor MRP2 predicted response to adjuvant cisplatin-based chemotherapy. Conclusions: MRP2 expression is an independent prognostic factor in patients with completely resected non–small cell lung cancer but neither MRP1 nor MRP2 was of predictive value in patients enrolled into the IALT.
Flexible sigmoidoscopy screening reduces colorectal cancer incidence and deaths, study shows
Authors: S. Mayor
Journal: BMJ (2014)

Screening with flexible sigmoidoscopy reduces the incidence of colorectal cancer by 20% and deaths from the disease by 27%, a large Norwegian population based study1 has shown. The study compared people who were undergoing screening with an unscreened control group.

Researchers used the Norwegian population register to randomly sample equal numbers of men and women aged 50 to 64 living in Oslo or the county of Telemark. They were randomly allocated to screening with either once only flexible sigmoidoscopy (n=10 283) or a combination of flexible sigmoidoscopy plus faecal occult blood testing (n=10 289), and the remaining people in those areas who were not screened became the control group (n=78 220).

The study participants …
Influence of Physical Training on Blood Glucose Control, Glucose Tolerance, Insulin Secretion, and Insulin Action in Non-insulin-dependent Diabetic Patients
Authors: Mariella Trovati, Quirico Carta, Franco Cavalot, Sara Vitali, Carlo Banaudi, Pietro Greco Lucchina, Franco Fiocchi, Giorgio Emanuelli, Gianfranco Lenti
Journal: Diabetes Care (1984)

This study has been designed to investigate, in five non-insulin-dependent diabetic patients, the influence of physical training (1 h a day, 7 days a wk for 6 wk, at 50-60% maximum oxygen uptake) on blood glucose control, glucose tolerance, insulin secretion, and insulin action. Physical training resulted in a significant improvement in blood glucose control, glucose tolerance, and insulin action. These results suggest that short-term intense physical training ameliorates the main metabolic derangements of non-insulin-dependent diabetes mellitus.
A Danger in Matched-Control Studies
Authors: Warren H. Gullen
Journal: JAMA (1980)

IN READING the medical research literature, one often sees references to or use of matched controls. This procedure may be included, for instance, in comparative drug trials or studies of the putative etiologic effect of certain environmental factors. Actually, there are a variety of research settings that may lend themselves to this approach. What do we mean by matching? Briefly, it ordinarily consists of the selection, for each test subject in a study (eg, one with a certain disease or receiving a certain therapy), of a comparison subject who is as similar to the test subject as possible except for the presence of the disease or treatment under investigation. One of the ways in which matching differs from stratification or blocking is that the comparison subjects in matching are selected individually to match individual test subjects. For example, in a case-control study of the possible effect of fiber consumption in
Cancer Therapy: Optically Traceable Solid Lipid Nanoparticles Loaded with siRNA and Paclitaxel for Synergistic Chemotherapy with In situ Imaging (Adv. Healthcare Mater. 4/2013)
Authors: Ki Hyun Bae, Jeong Yu Lee, Soo Hyeon Lee, Tae Gwan Park, Yoon Sung Nam
Journal: Advanced Healthcare Materials (2013)

Optically traceable, low-density lipoprotein (LDL)-mimetic solid lipid nanoparticles (SLNs) loaded with Bcl-2 siRNA, paclitaxel, and CdSe/ZnS quantum dots for synergistic combination chemotherapy are reported by Yoon Sung Nam and co-workers on page 576. The LDL-mimetic SLNs deliver both paclitaxel and siRNA and exhibit synergistic anticancer activities through caspase-mediated apoptosis. The strong fluorescence from the quantum dots enables in situ optical monitoring of drug delivery.
Dual inhibition of α<sub>V</sub> integrins and Src kinase activity in colon cancer cells
Authors: A. Starodub, J. Jia, S. Cushman, D. Marshall, H. I. Hurwitz, A. B. Nixon
Journal: Journal of Clinical Oncology (2009)

e14609 Background: Integrins are commonly upregulated in tumor cells and are important regulators of invasion and metastasis. Integrin signaling is initiated upon engagement of ECM and requires Src as well as various other proteins including ILK, FAK, and paxillin. Methods: Presence of αv integrins on CRC cell lines was established by flow cytometry. CNTO 95 (10μg/ml, a monoclonal anti-αv integrin antibody; Ortho Biotech), and dasatinib (&lt;200nM; BMS, src small molecule inhibitor) were used to study the effects of combined integrin and src inhibition on proliferation and serum-induced migration of colon cancer cell lines in vitro. Downstream signaling changes were assessed by immunoblotting for phosphorylated forms of src, FAK (Y397, Y576/577 and Y925), paxillin, GSK3β and AKT (S473) in HT29, HCT116 and RKO. Results: Proliferation was inhibited by dasatinib in HT29, HCT116, DLD1 and HCT15 in a dose-dependent manner, while RKO and SW48 were resistant. Combining CNTO 95 with dasatinib further inhibited proliferation in all dasatinib-sensitive cells, yet resistant cells were unaffected. Migration was blocked by both CNTO 95 and dasatinib in all cell lines, and combining the two drugs produced augmented effect. Src activation and src- dependent FAK phosphorylation at sites 576 and 925 were blocked by dasatinib; CNTO 95 had little effect alone, but potentiated the effect of dasatinib. Paxillin phosphorylation was modestly blocked by both compounds, but the combination produced significantly augmented inhibition in the three cell lines tested. The phosphorylation status of AKT and GSK-3β, which are downstream of ILK, was inhibited by both drugs as single agents. The combination of dasatinib and CNTO 95 produced further inhibition. Conclusions: Dual inhibition of Src by dasatinib and αv integrins by CNTO 95 produced additive to synergistic inhibition of proliferation in dasatinib sensitive CRC cell lines, and inhibition of migration in all cell lines tested. Decreased phospho-paxillin levels may be responsible for the pronounced inhibition of migration observed after dual treatment with dasatinib and CNTO 95 in these CRC cell lines. These data support the rationale for combined Src/integrin inhibition in colon cancer, and further suggest approaches to patient selection strategies. [Table: see text]
The Genetics Revolution and Primary Care Pediatrics
Authors: Tina L. Cheng, Ronald D. Cohn, George J. Dover
Journal: JAMA (2008)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Complication of Cantor-Tube Insertion
Authors: F E Wien, J Cooperman
Journal: New England Journal of Medicine (2001)

Figure 1. A 61-year-old man with metastatic colon carcinoma was hospitalized with small-bowel obstruction. A Cantor tube was placed in the stomach with instructions to the nurse to advance the tube gradually and periodically until it progressed into the small bowel. Two days later, a radiograph showed that the Cantor tube was knotted in the gastric lumen (Panel A) and could not be withdrawn. Endoscopy was performed (Panel B), the knot was partially untied, and the tube was removed. The flexible nature of the tube, the routine practice of blindly advancing the tube at the bedside, the apparent failure of . . .
Agranulocytosis after Imipramine and Meprobamate
Authors: T. P. Curran, E. Barabas
Journal: BMJ (1961)

MEDICAL TOURNALAgranulocytosis after Imipramine and Meprobamate We have lately observed the fatal outcome of agranulocytosis in a patient after treatment with imipramine ("tofranil") and meprobamate ("equanil") for involutional depression.As both drugs have the reputation of low toxicity and a low incidence of fatality, this case is of interest.CASE REPORT A multipara aged 56 was admitted to hospital on April 9 with a history of depression of varying severity and of at least four months' duration.She had been treated for 41 days with meprobamate in 400-mg.doses t.d.s. and imipramine, 25 mg.t.d.s., the dosage of the latter being increased to 50 mg.t.d.s. 10 days before her admission.She was drowsy and restless and looked critically ill.She complained of sore throat and dysphagia lasting three to four days, was running a temperature of 100.4°F.(38' C.),
Critical role of CDK2 for melanoma growth linked to its melanocyte-specific transcriptional regulation by MITF
Authors: Jinyan Du, Hans R. Widlund, Martin A. Horstmann, Sridhar Ramaswamy, Ken Ross, Wade E. Huber, Emi K. Nishimura, Todd R. Golub, David E. Fisher
Journal: Cancer Cell (2004)
Role of TNF-? in ethanol-induced hyperhomocysteinemia and murine alcoholic liver injury
Authors: Cheng Ji, Qinggao Deng, Neil Kaplowitz
Journal: Hepatology (2004)

We previously reported a link between ethanol-induced elevation of homocysteine, endoplasmic reticulum (ER) stress, and alcoholic liver injury in the murine model of intragastric ethanol feeding. We studied the role of TNFα in this setting by using TNFR1 knockout mice (C57 BL/6). There was a 7.4-fold increase of homocysteine in wild-type and a 6-fold increase in TNFR1 knockout mice with intragastric alcohol exposure for 4 weeks. Plasma TNFα increased in the wild-type (18.4 ± 3.3 pg/mL vs. 8.4 ± 1.3 pg/mL (control)) and in the knockouts (12.9 ± 1.4 pg/mL vs. 7.2 ± 1.6 pg/mL (control)). Similar extent of fatty liver was observed in both types. Increased ALT was observed in both groups. Necroinflammatory foci were increased significantly in ethanol-fed knockouts but not to the same extent as in the ethanol-fed wild type. Increase of hepatic apoptosis and reduction of S-adenosyl-L-methionine was detected in both types of animals fed ethanol. ER stress demonstrated by RT-PCR of mRNA of selective ER stress markers GRP78, CHOP, and SREBP1 was increased equivalently in both types of mice. Betaine administration decreased ER stress in conjunction with attenuation of the elevated plasma homocysteine in both types of animals. Betaine increased hepatic S-adenosyl-L-methionine by 28 fold in the knockouts and by 24-fold in wild type. In conclusion , TNFα makes a moderate contribution to the ALT elevation, necroinflammation, apoptosis, a small contribution to the fatty liver and no contribution to hyperhomocysteinemia and ER stress in intragastric alcohol fed mice. (Hepatology 2004;40:442-451.)
Joint Annual Meeting, Karachi
Authors: H. A. Khan
Journal: BMJ (1966)

Sir,?The British Medical Association is holding its 134th Annual Scientific Meeting at Karachi between 29 November and 3 December jointly with the 11th Biennial Meeting of the Pakistan Medical Association. The Pakistan Medical Association is affiliated to the British Medical Association and the two are joined together with close bonds of friendship and brotherhood. The purpose of the Joint Meeting is further to strengthen these ties, and this can be achieved only if a large number of members of both Associa tions get a chance to meet and know each other better and also exchange each others' ideas. For the last two years I had the privilege of addressing the Representative Body of the British Medical Association and to extend to its members a personal invita tion. Now again I have the pleasure to renew the same invitation through the columns of the British Medical Journal. The Karachi climate will be at its best at the time of the Meeting and my committee have drawn up a very interesting scientific and social programme. I sincerely hope that a large number of members of the British Medical Association will be able to attend this Joint Meeting, and I assure them of a warm and cordial welcome. I also hope that a good number of them will be accompanied by their wives, for whom also my Ladies Committee has drawn up a very interesting programme.?I am, etc., Hamid Ali Khan, President-Elect, Pakistan Medical Association Karachi. and British Medical Association.
The tricho-rhino-phalangeal syndrome
Authors: DEBORAH J. MCCLOUD, LAWRENCE M. SOLOMON
Journal: British Journal of Dermatology (1977)

Journal Article The tricho‐rhino‐phalangeal syndrome Get access DEBORAH J. MCCLOUD, DEBORAH J. MCCLOUD Department of Dermatology, Abraham Lincoln School, University of Illinois College of Medicine, P.O. Box 6998, Chicago, Illinois 60680, U.S.A. Search for other works by this author on: Oxford Academic Google Scholar LAWRENCE M. SOLOMON LAWRENCE M. SOLOMON Department of Dermatology, Abraham Lincoln School, University of Illinois College of Medicine, P.O. Box 6998, Chicago, Illinois 60680, U.S.A. Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 96, Issue 4, 1 April 1977, Pages 403–407, https://doi.org/10.1111/j.1365-2133.1977.tb07136.x Published: 01 April 1977
TREATMENT OF REPERFUSION INJURY WITH RECOMBINANT ADAMTS13 IN A PORCINE MODEL OF ACUTE MYOCARDIAL INFARCTION
Authors: E.S. Eerenberg, P.F.A. Teunissen, B.J. Van Den Born, J.C. Meijers, M. Hollander, M. Aly, H.W.M. Niessen, Pieter Willem Kamphuisen, M. Levi, N. Van Royen
Journal: Journal of the American College of Cardiology (2013)
Building a successful partnership between management and clinical leadership: experience from New Zealand
Authors: L. Malcolm
Journal: BMJ (2003)

Recent New Zealand studies have shown important progress in addressing a key issue facing all health systems: the gap between clinical culture and governance or managerial culture. 1 2 The key terms in this progress are partnership, quality, clinical leadership, and professionalism.

Three factors have been important. Firstly, New Zealand—with a national per capita income some 20% below the mean for member countries of the Organisation for Economic Co-operation and Development—has had to make difficult choices about health priorities. This has compelled greater collaboration between clinicians and management. In primary care, major budget management—of drugs, for example—is being seen …
Does social disadvantage contribute to the excess mortality in rheumatoid arthritis patients?
Authors: N Maiden, H A Capell, R Madhok, R Hampson, E A Thomson
Journal: Annals of the Rheumatic Diseases (1999)

Socioeconomic deprivation is associated with increased mortality from cardiovascular causes and malignancy. The influence of disadvantage in patients with rheumatoid arthritis (RA), who are known to have premature mortality, has not been ascertained.To assess the relation between the level of patient deprivation and mortality in RA patients.200 RA patients, enrolled in a study comparing sulfasalazine and penicillamine in 1984-85, have been followed up prospectively for 12 years. Subjects were categorised into Carstairs groups with deprivation scores ranging from 1 (most affluent) to 7 (most deprived). Information about deaths was obtained from the Registrar General in Scotland, death certificates and GP/hospital records.There were more RA patients in the deprived areas then expected compared with the West of Scotland and England and Wales. Some 47.5% of the RA patients had died by 12 years-the majority of cardiorespiratory causes or malignancy. There were no differences in the median age or disease duration in the various Carstairs groups at study entry, but the percentage of deaths was higher in the more deprived groups after 12 years (36% dead in most affluent area compared with 61% in the most deprived, that is, in groups 6 and 7).In patients with RA increasing deprivation was associated with premature mortality. If confirmed elsewhere these findings have implications for rheumatological management strategies, for researchers involved in collaborative studies of patients from different socioeconomic backgrounds and for resource allocation.
Specificity Concepts Reflected by Psychoanalytic Epidemiology
Authors: T. Reitter, W. Tress
Journal: Psychotherapy and Psychosomatics (1989)

The issue of whether there are specific constellations of intrapsychic conflicts, personality structures and symptom patterns within the general population is investigated by means of a representative epidemiological field cohort study. Out of a population of 600 adults three groups are compared: probands who are suffering from functional cardiac symptoms, those who are suffering from headaches and a sample of 'healthy' probands. The interview protocols of these probands were examined to identify typical conflict patterns. Finally the raters had to give a 'blind' overall diagnosis. Six criteria differentiating the 3 samples were identified and the 'blind' overall ratings were compared with the actual diagnosis. The results are discussed with regard to a hypothesis from the literature.
Comparative Severity of Atherosclerosis in Costa Rica, Guatemala, and New Orleans
Authors: CARLOS TEJADA, IRA GORE, JACK P. STRONG, HENRY C. MCGILL
Journal: Circulation (1958)

The present study is concerned with the comparative severity of aortic atherosclerosis in specimens obtained from 941 necropsies performed in low-income Costa Ricans, Guatemalans, and New Orleans whites. The findings indicate geographic differences in the severity of atherosclerosis after the age of 30 years. The dietary habits, serum cholesterol, and lipoprotein patterns of similar populations are compared with the present pathologic findings.
N-GAL INDICATING ACUTE KIDNEY INJURY AND GFR INFLUENCE THE PROGNOSIS OF PATIENTS WITH ACUTE SYMPTOMATIC PULMONARY EMBOLISM
Authors: Maciej Kostrubiec, Justyna Pedowska-Wloszek, Andrzej Labyk, Szymon Pacho, Krzysztof Jankowski, Michal Ciurzynski, Piotr Pruszczyk
Journal: Journal of the American College of Cardiology (2011)
Idiopathic Focal Proliferative Nephritis Associated with Persistent Hematuria and Normal Renal Function
Authors: ABRAHAM RAPOPORT
Journal: Annals of Internal Medicine (1970)

Thirty-three patients with "active" urinary sediments (containing red cells and red cell or heme granular casts) that have persisted up to 10 years without significant deterioration in renal function are described. Fourteen patients presented with sore throat or gross hematuria, or both, and the other 19 were discovered through abnormal routine urinalyses. Since no difference was observed in most of their clinical, renal functional, or histological features, both groups are considered to represent the same disease process. No patient had edema, renal hypertension, or evidence of a systemic disease. In all cases most glomeruli seen in renal biopsies were normal. When lesions were observed, a focal, usually segmental, proliferative glomerulonephritis predominated. These cases probably represent a form of focal, proliferative nephritis of presently unknown cause. The differential diagnosis between this condition, acute poststreptococcal nephritis, and "latent chronic" glomerulonephritis is discussed. The distinction is important because idiopathic focal proliferative nephritis may have not only a different cause but also a more benign prognosis.
Selective inhibition of 2-AG hydrolysis enhances endocannabinoid signaling in hippocampus
Authors: Judit K Makara, Marco Mor, Darren Fegley, Szilárd I Szabó, Satish Kathuria, Giuseppe Astarita, Andrea Duranti, Andrea Tontini, Giorgio Tarzia, Silvia Rivara, Tamás F Freund, Daniele Piomelli
Journal: Nature Neuroscience (2005)