tbuckley/cabot-search huggingface dataset:
Surgeon who owned hospital faces 69 charges of flawed treatment and four of manslaughter
Authors: Ned Stafford
Journal: BMJ (2008)

A chief surgeon who also owned the village hospital in Germany where he practised is in jail awaiting trial in connection with the deaths of seven patients.

Arnold Pier, 52, has been accused by prosecutors in a 400 page court document of making incorrect diagnoses and carrying out unnecessary operations (such as removing appendices or gall bladders) at the St Antonius Clinic in Wegberg, in the western state of North Rhine-Westphalia.

In addition, Dr Pier, who was also chief administrator at the hospital, allegedly followed lax standards of hygiene, including using lemon juice as a disinfectant during surgery.

Prosecutors issued a …
Epidermal Growth Factor Receptor (EGFR) Signaling and Covalent EGFR Inhibition in Lung Cancer
Authors: Johannes M. Heuckmann, Daniel Rauh, Roman K. Thomas
Journal: Journal of Clinical Oncology (2012)

Article Tools UNDERSTANDING THE PATHWAY Article Tools OPTIONS & TOOLS Export Citation Track Citation Add To Favorites Rights & Permissions COMPANION ARTICLES No companion articles ARTICLE CITATION DOI: 10.1200/JCO.2012.43.1825 Journal of Clinical Oncology - published online before print August 20, 2012 PMID: 22915655 Epidermal Growth Factor Receptor (EGFR) Signaling and Covalent EGFR Inhibition in Lung Cancer Johannes M. HeuckmannxJohannes M. HeuckmannSearch for articles by this author , Daniel RauhxDaniel RauhSearch for articles by this author , Roman K. ThomasxRoman K. ThomasSearch for articles by this author https://doi.org/10.1200/JCO.2012.43.1825 First Page Full Text PDF Figures and Tables © 2012 by American Society of Clinical Oncology
Deep Waters Run Still
Authors: Theodore B. Schwartz
Journal: Annals of Internal Medicine (2001)

On Being a Patient4 September 2001Deep Waters Run StillTheodore B. Schwartz, MDTheodore B. Schwartz, MDDr. Schwartz: Rush Medical College, Evanston, IL 60202Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-135-5-200109040-00016 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail The Schwartzes—Gen and me—and a couple I will call the Wilsons have been friends for nearly a half century. I first came to know Don Wilson as a careful, highly competent general surgeon. Early on, I was put off by what I considered to be his pre-Baconian notions of what constitutes the scientific method, but regardless, we became good friends. Over the years, our friendship evolved into a comfortable intimacy, the more so as the ranks of our social circle became thinned by incapacity or death. At present, Don is 93 years old, 11 years my senior.We had fun. ... Author, Article, and Disclosure InformationAffiliations: Dr. Schwartz: Rush Medical College, Evanston, IL 60202Corresponding Author: Theodore B. Schwartz, MD, 200 Lee Street, Apartment 1A, Evanston, IL 60202; e-mail, [email protected]com. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byLife on the Receiving End: A Qualitative Analysis of Health Providers??? Illness Narratives 4 September 2001Volume 135, Issue 5Page: 378-379KeywordsInterleukinsLesionsMortalityNursesPerceptionShort term memorySoapsStent implantationSurgeonsVeins ePublished: 4 September 2001 Issue Published: 4 September 2001 Copyright & PermissionsCopyright © 2001 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Animal models of beryllium-induced lung disease.
Authors: G L Finch, M D Hoover, F F Hahn, K J Nikula, S A Belinsky, P J Haley, W C Griffith
Journal: Environmental Health Perspectives (1996)

The inhalation Toxicology Research Institute (ITRI) is conducting research to improve the understanding of chronic beryllium disease (CBD) and beryllium-induced lung cancer. Initial animal studies examined beagle dogs that inhaled BeO calcined at either 500 or 1000 degrees C. At similar lung burdens, the 500 degrees C BeO induced more severe and extensive granulomatous pneumonia, lymphocytic infiltration into the lung, and positive Be-specific lymphocyte proliferative responses in vitro than the 1000 degrees C BeO. However, the progressive nature of human CBD was not duplicated. More recently, Strains A/J and C3H/Hej mice were exposed to Be metal by inhalation. This produced a marked granulomatous pneumonia, diffuse infiltrates, and multifocal aggregates of interstitial lymphocytes with a pronounced T helper component and pulmonary in situ lymphocyte proliferation. With respect to lung cancer, at a mean lung burden as low as 17 micrograms Be/g lung, inhaled Be metal induced benign and/or malignant lung tumors in over 50% of male and female F344 rats surviving > or = 1 year on study. Substantial tumor multiplicity was found, but K-ras and p53 gene mutations were virtually absent. In mice, however, a lung burden of approximately 60 micrograms (-300 micrograms Be/g lung) caused only a slight increase in crude lung tumor incidence and multiplicity over controls in strain A/J mice and no elevated incidence in strain C3H mice. Taken together, this research program constitutes a coordinated effort to understand beryllium-induced lung disease in experimental animal models.
Triglycerides and the Risk of Coronary Heart Disease
Authors: Nadeem Sarwar, John Danesh, Gudny Eiriksdottir, Gunnar Sigurdsson, Nick Wareham, Sheila Bingham, S. Matthijs Boekholdt, Kay-Tee Khaw, Vilmundur Gudnason
Journal: Circulation (2006)

Background— Many epidemiological studies have reported on associations between serum triglyceride concentrations and the risk of coronary heart disease, but this association has not been reliably quantified. In the present study, we report 2 separate nested case-control comparisons in 2 different prospective, population-based cohorts, plus an updated meta-analysis of 27 additional prospective studies in general Western populations. Methods and Results— Measurements were made in a total of 3582 incident cases of fatal and nonfatal coronary heart disease and 6175 controls selected from among the 44 237 men and women screened in the Reykjavik and the European Prospective Investigation of Cancer (EPIC)-Norfolk studies. Repeat measurements were obtained an average of 4 years apart in 1933 participants in the EPIC-Norfolk Study and an average of 12 years apart in 379 participants in the Reykjavik study. The long-term stability of log-triglyceride values (within-person correlation coefficients of 0.64 [95% CI, 0.60 to 0.68] over 4 years and 0.63 [95% CI, 0.57 to 0.70] over 12 years) was similar to those of blood pressure and total serum cholesterol. After adjustment for baseline values of several established risk factors, the strength of the association was substantially attenuated, and the adjusted odds ratio for coronary heart disease was 1.76 (95% CI, 1.39 to 2.21) in the Reykjavik study and 1.57 (95% CI, 1.10 to 2.24) in the EPIC-Norfolk study in a comparison of individuals in the top third with those in the bottom third of usual log-triglyceride values. Similar overall findings (adjusted odds ratio, 1.72; 95% CI, 1.56 to 1.90) were observed in an updated meta-analysis involving a total of 10 158 incident coronary heart disease cases from 262 525 participants in 29 studies. Conclusions— Available prospective studies in Western populations consistently indicate moderate and highly significant associations between triglyceride values and coronary heart disease risk. Because these associations depend considerably on levels of established risk factors, however, further studies are needed to help assess the nature of any independent associations.
Abstract LB-373: Parp1 dependent regulation of chromatin remodeling by the ALC1 (Amplified in Liver Cancer) oncogene
Authors: Aaron J. Gottschalk, Rushi D. Trivedi, Joan W. Conaway, Ronald C. Conaway
Journal: Cancer Research (2012)

Abstract The human ALC1 (Amplified in Liver Cancer 1) gene was originally identified as a gene present on a human chromosome 1q21 region amplified in a large fraction of hepatocellular carcinomas. Subsequent studies found that overexpression of the ALC1 protein was found to be oncogenic in human cells and mice, although the mechanism of action of ALC1 in oncogenesis is not known. The human ALC1 gene encodes a member of the SNF2 superfamily of ATPases. The ALC1 protein is unique among SNF2 family members because it includes a macrodomain that is capable of binding selectively to poly(ADP-ribose) (PAR). We and others have also previously demonstrated that ALC1 possesses DNA-dependent ATPase and ATP-dependent nucleosome remodeling activities that are strongly dependent on the presence of poly(ADP-ribose) polymerase PARP1 (or the closely related PARP2) and NAD+ within in vitro assays. Our preliminary investigation of the mechanism of PARP1- and NAD+-dependent activation of ALC1 DNA-dependent ATPase and nucleosome remodeling activities revealed (i) that both the ALC1 SNF2 ATPase domain and an intact macrodomain capable of binding PAR are essential for activation by PARP1 and NAD+, (ii) that activation of ALC1 in the presence of PARP1 and NAD+ results in increased affinity of ALC1 for DNA and nucleosomes, and (iii) that autoPARylated PARP1 is most likely the source of PAR required for activation of ALC1. These preliminary observations provided some insight into basic features of the function of the ALC1 protein, but they left unresolved major questions concerning the mechanism by which ALC1 is activated by PARP1 and NAD+ to remodel nucleosomes. In our recent studies, we extend our investigation of the mechanism by which ALC1 is “activated” to remodel nucleosomes by PARP1 and NAD+. Our findings argue that (i) ALC1 activation requires assembly of a stable ALC1.autoPARylated PARP1.nucleosome intermediate, (ii) that ALC1 regulates association of autoPARylated PARP1 with this intermediate, and (iii) stable binding of the ALC1 macrodomain to autoPARylated PARP1 is critical for ALC1 activation. Taken together, our findings are consistent with the model that a stable ALC1.autoPARylated PARP1 heterodimer is the active species in ALC1-dependent ATPase and nucleosome remodeling. These findings provide further important insight into the mechanism of action of this poorly understood oncogene. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 103rd Annual Meeting of the American Association for Cancer Research; 2012 Mar 31-Apr 4; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2012;72(8 Suppl):Abstract nr LB-373. doi:1538-7445.AM2012-LB-373
123. Cysteine Protease Inactivation of Adenovirus Is Responsible for Thermal Stress-Induced Adenovirus Infectivity Loss
Authors: De-Min Zhu, Donna Williams, Shilu Wu
Journal: Molecular Therapy (2006)

Adenoviral vectors (Ad), known for its efficiency in gene delivery, are currently used for Merck's developmental HIV vaccine. A formulation has been developed to stabilize the adenovirus serotype 5 (Ad5) at 2-8°C storage. In support of formulation development, we have used QPCR, in vitro antigen expression (IVAE), flow cytometry, microscopy, an enzymatic assay, and animal study to investigate the inactivation pathway of Ad5 vector containing HIV-1 gag gene (Ad5gag) induced by thermal stress (15-37°C).
Deciding whether to be a doctor.
Authors: J. Parker-Williams
Journal: BMJ (1992)

are not itemised and not for debate may drive person responsible for the preregistration year in address this issue and to plan prospective trials.industrial support elsewhere in Europe and to this medical school, I know that consultants are These trials will also incorporate regimens for other countries, concerned that some graduates have difficulty in planned prophylaxis and an appraisal of the inci- P GRIFFIN completing their year as a house officer.These dence of factor VIII antibodies.Concern has F 0 WELLS doctors' undergraduate records often show the been expressed that treatment with monoclonally Association of the British Pharmaceutical Industrv, signs of impending disaster.The arguments for derived high purity products is associated with an London SWIA 2DY~~~~~~~~~their continuing the course are as Kelly outlined; tncreased incidence of inhibitors.-D SWALES when they are challenged to account for their There remains the question whether highAssciaionof lincalProessrs f Mdicne B ANES poor performance they give many reasons, but purity factor VIII prevents down regulation of the Departmenit of Medicine, how seriously is their commitment to medicine immune system.Evidence of benefit continues to St George's Hospital, questioned?accumulate, as indicated recently by de Biasi et al.
Boredom in War
Authors: Terrence L. Riley
Journal: JAMA (1982)

<h3>To the Editor.—</h3> I refer to Dr Foraker's editorial entitled "Home Is the Sailor" (1982;247:2710). Although I spent six rewarding years as a Navy physician, I am happy to confess that, like Dr Foraker's friends, I never had to face battle; nobody ever shot at me. Perhaps, therefore, Dr Foraker will feel it out of place for me to take exception to some of his complaints. He thought it was boring and a waste of time to be on ships in his country's defense in the most threatening war of history. That boredom was forced on millions of young men in those years who did not have the opportunities nor the wherewithal to become physicians. I doubt that those who had the good fortune to become physicians should deserve a waiver from such boredom. As to his duty being a "waste of time," I suspect he has only himself to
The Relationship Between Physicians' Malpractice Claims History and Later Claims
Authors: Martin G. Wertkin
Journal: JAMA (1995)

To the Editor.  —The article by Messrs Bovbjerg and Petronis 1 on the predictive value of physicians' malpractice claims experience and the excellent Commentary by Mr Smarr 2 fail to consider an important determinant of a physician's risk of incurring a malpractice claim, namely, practice volume.  It stands to reason that the more patients a physician treats, the more likely that physician is to have a bad result or unanticipated outcome, to encounter an angry or litigious patient, or to make a mistake. The larger the practice, the more the exposure, and this exposure increases with each subsequent year in practice. As one of my surgery professors used to half joke: Any surgeon who has been in practice 10 or more years and has not been sued simply isn't busy enough.  It would be interesting to factor practice volume into the odds ratios of Bovbjerg and Petronis. If there is a
The HBV Carrier — A New Kind of Leper?
Authors: James W. Mosley
Journal: New England Journal of Medicine (1975)

Persons in medicine, dentistry, and allied professions have an enormous stake in their continued ability to give direct health care. Forced into administrative and other positions involving no patient contact, even when comparable remuneration is offered, many workers committed to patient care would not find comparable satisfaction. More importantly, they would be unable to use skills both needed by the public and arduously acquired by themselves at the cost of years of deferred income and very hard work. Nonetheless, there is the possibility that an estimated 1 per cent or more of health-care professionals, the carriers of hepatitis B virus . . .
Diminishing Response to Ephedrine
Authors: Pisit Rangsithienchai
Journal: JAMA (1978)

<h3>To the Editor.—</h3> Several authors have recently reevaluated the use of ephedrine sulfate for asthma in adults<sup>1,2</sup>and children.<sup>3-5</sup>Its bronchodilating effects have generally been confirmed, and no tachyphylaxis has been found. This has been in contrast to the loss of effect reported by Herxheimer<sup>6</sup>in patients taking the drug for only a few days. We have observed an instance of asthma consistently worsening after first responding to ephedrine therapy. <h3>Report of a Case.—</h3> A 12-year-old boy was referred to La Rabida Children's Hospital for treatment of asthma that had been poorly controlled since its onset at 4 years of age. Initial assessment showed severe obstructive lung disease. After oral aminophylline was given to maintain serum theophylline levels at 15 to 20 μg/ml, considerable improvement occurred, but pulmonary function testing continued to show moderate obstruction, not completely reversed by subcutaneous epinephrine or inhaled isoproterenol. His peak expiratory
A case of adult T-cell leukaemia/lymphoma characterized by multiplex-fluorescence in situ hybridization, comparative genomic hybridization, fluorescence in situ hybridization and cytogenetics
Authors: X. Mao, D.M. Lillington, B. Czepulkowski, B.D. Young, R. Russell-Jones, S. Whittaker
Journal: British Journal of Dermatology (2001)

Journal Article A case of adult T‐cell leukaemia/lymphoma characterized by multiplex‐fluorescence in situ hybridization, comparative genomic hybridization, fluorescence in situ hybridization and cytogenetics Get access X. Mao, X. Mao Skin Tumour Unit, St John's Institute of Dermatology, St Thomas' Hospital, London SE1 7EH, U.K. Dr Xin Mao. E‐mail: mxmayo@hotmail.com Search for other works by this author on: Oxford Academic Google Scholar D.M. Lillington, D.M. Lillington ICRF Department of Medical Oncology, Saint Bartholomew's Hospital, London, U.K. Search for other works by this author on: Oxford Academic Google Scholar B. Czepulkowski, B. Czepulkowski Department of Haematological Medicine, King's College Hospital, London, U.K. Search for other works by this author on: Oxford Academic Google Scholar B.D. Young, B.D. Young ICRF Department of Medical Oncology, Saint Bartholomew's Hospital, London, U.K. Search for other works by this author on: Oxford Academic Google Scholar R. Russell‐Jones, R. Russell‐Jones Skin Tumour Unit, St John's Institute of Dermatology, St Thomas' Hospital, London SE1 7EH, U.K. Search for other works by this author on: Oxford Academic Google Scholar S. Whittaker S. Whittaker Skin Tumour Unit, St John's Institute of Dermatology, St Thomas' Hospital, London SE1 7EH, U.K. Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 145, Issue 1, 1 July 2001, Pages 117–122, https://doi.org/10.1046/j.1365-2133.2001.04294.x Published: 01 July 2001
Mutation of human keratin 18 in association with cryptogenic cirrhosis.
Authors: N O Ku, T L Wright, N A Terrault, R Gish, M B Omary
Journal: Journal of Clinical Investigation (1997)

Mutations in 11 of the more than 20 keratin intermediate filaments cause several epidermal and oral associated diseases. No disease-associated mutations have been described in keratin 8 or 18 (K8/18) which are the major keratin pair in simple-type epithelia, as found in the liver, pancreas, and intestine. However, transgenic mice that express mutant keratin 18 develop chronic hepatitis, and have an increased susceptibility to drug-induced hepatotoxicity. Also, ectopic expression of epidermal K14 in mouse liver results in chronic hepatitis, and disruption of mouse K8 leads to embryo lethality with extensive liver hemorrhage. We tested if patients with liver disease of unknown cause may harbor mutations in K18. We describe a his127-->leu (H127L) K18 mutation in a patient with cryptogenic cirrhosis that is germline transmitted. The K18 H127L isolated from the liver explant, or after expression in bacteria, showed an altered migration on two-dimensional gel analysis as compared with normal human liver or bacterially expressed K18. Electron microscopy of in vitro assembled K18 H127L and wild type K8 showed an assembly defect as compared with normal K8/18 assembly. Our results suggest that mutations in K18 may be predispose to, or result in cryptogenic cirrhosis in humans.
Monitoring Inspired Oxygen Pressures During Mechanical Ventilation
Authors: Timothy M. Harris
Journal: JAMA (1968)

Ventilators which provide a 40% mixture of oxygen with air are commonly employed in the management of respiratory failure. When set on air mix and powered by compressed-oxygen sources, the ventilators may deliver high and unpredictable partial pressures of oxygen. Measurement of inspired partial pressures of oxygen (PIO<sub>2</sub>) is important in identifying patients receiving excessive oxygen concentrations, and in monitoring patients in respiratory failure. The technique for sampling and measuring the PIO<sub>2</sub>is exceedingly simple and reliable. The difference between the partial pressure of oxygen in the inspired gas and the partial pressure of oxygen in the arterial blood is an approximate indicator of the effective oxygen transport in the lungs.
<i>Mycobacterium chelonae</i> infection complicating cosmetic facial surgery
Authors: M. Saha, B.S. Azadian, L. Ion, C.B. Bunker
Journal: British Journal of Dermatology (2006)

Journal Article Mycobacterium chelonae infection complicating cosmetic facial surgery Get access M. Saha, M. Saha Departments of Dermatology, Microbiology Search for other works by this author on: Oxford Academic Google Scholar B.S. Azadian, B.S. Azadian Departments of Dermatology, Microbiology Search for other works by this author on: Oxford Academic Google Scholar L. Ion, L. Ion Plastic Surgery, Chelsea and Westminster Hospital, Imperial College School of Medicine, London SW10 9NH, U.K. E‐mail: monikasaha@doctors.net.uk Search for other works by this author on: Oxford Academic Google Scholar C.B. Bunker C.B. Bunker Departments of Dermatology, Microbiology Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 155, Issue 5, 1 November 2006, Pages 1097–1098, https://doi.org/10.1111/j.1365-2133.2006.07507.x Published: 01 November 2006
Changing Imaging Patterns After Testicular Torsion Demonstrated by Serial Scintigraphic Studies
Authors: AKIN YILDIZ, İSMAIL BALTAOĞLU, AYSUN ÖZDEMIR, FIRAT GÜNGÖR, BINNUR KARAYALĈIN, EROL GÜNTEKIN
Journal: Clinical Nuclear Medicine (1999)

An 18-year-old man who had spontaneous scrotal pain for 12 hours was seen in the emergency room of our university hospital. Testicular scintigraphy was performed to make a differential diagnosis between torsion and epididymitis. Results of the scintigraphic examination were interpreted as consistent with early left-sided testicular torsion. Manual detorsion under general anesthesia was performed by urologists. Radionuclide imaging repeated 3 days after detorsion showed a halo sign that indicated delayed testicular torsion. Conservative management was favored after manual detorsion based on the operative findings, despite the findings of the scintigraphic studies, which showed delayed testicular torsion. Repeated scintigraphic imaging 15 days after detorsion revealed moderately increased activity in the untwisted testis. Six months after torsion, testicular scintigraphy was performed again and revealed hypoactivity in the affected testicle, suggesting that the testicle had undergone atrophic changes. Overall scintigraphic findings showed physiopathologic changes after testicular torsion.
1188 GS-6620, A LIVER-TARGETED NUCLEOTIDE PRODRUG, EXHIBITS ANTIVIRAL ACTIVITY AND FAVORABLE SAFETY PROFILE OVER 5 DAYS IN TREATMENT NAIVE CHRONIC HCV GENOTYPE 1 SUBJECTS
Authors: E. Lawitz, J. Hill, T. Marbury, L. Hazan, D. Gruener, L. Webster, R. Majuskas, R. Morrison, M. DiMcco, P. German, D. Stefanidis, E. Svaroskaia, A. Jain, S. Arterburn, A. Ray, S. Rossi, J. McHutchson, M. Rodriguez-Torres
Journal: Journal of Hepatology (2012)
Airway remodeling in subjects with severe asthma with or without chronic persistent airflow obstruction
Authors: Marta Kaminska, Susan Foley, Karim Maghni, Claudine Storness-Bliss, Harvey Coxson, Heberto Ghezzo, Catherine Lemière, Ronald Olivenstein, Pierre Ernst, Qutayba Hamid, James Martin
Journal: Journal of Allergy and Clinical Immunology (2009)