tbuckley/cabot-search huggingface dataset:
Abstract 21: Accounting For Smoking Behavior In Genome-wide Analysis Of Obesity Phenotypes: The Giant (genetic Investigation Of Anthropometric Traits) Consortium
Authors: Anne Justice, Thomas Winkler, Julius Ngwa, Jacek Czajkowski, Kristin Young, David Hadley, Mariaelisa Graf, Daniel Chasman, Qibin Qi, M. Carola Zillikens, Mary F Feitosa, Tarunveer S Ahluwalia, Paul Franks, Tuomas O Kilpeläinen, Toomas Haller, Keri Monda, Claude Bouchard, Nancy L Heard-Costa, Nese Direk, Henning Tiemeier, Ingrid Borecki, Ruth Loos, Kari North, L. Adrienne Cupples
Journal: Circulation (2014)

Obesity, especially central obesity, and cigarette smoking (SMK) are both important risk factors for cardiovascular disease (CVD). Yet, smokers often exhibit lower body mass index (BMI) and higher waist circumference (WC) compared to non-smokers; also, smoking cessation leads to weight gain. Genome-wide association (GWA) studies have identified genetic loci that are associated with risk of overall and central obesity; yet little is known about whether and how SMK influences the genetic susceptibility to obesity. This study aims to discover genetic loci that are associated with obesity, measured as BMI and WC adjusted for BMI (WC a ), and where the effects are hidden by SMK. We used results from 42 studies including up to 126,767 subjects with GWA data available through the GIANT Consortium. Each study employed three association models while considering smoking status (current vs. not current smokers): 1) SNP effects adjusted for SMK (SNPadjSmk), 2) SNP by SMK interaction effects (SNPxSMK), and 3) joint effect of SNP and the SNP x SMK interaction effect (SNPxSMK J ). Study specific results were combined by inverse-variance weighted fixed-effects meta-analyses of the study specific results in men and women separately and then combined sexes. A total of 53 SNPs for WC a reached genome-wide significance (GWS) (p&lt;1E-8) by adjusting for and allowing for interaction with SMK (SNPadjSMK and SNPxSMK J ), 27 of these loci are novel for WC a . Additionally, SNPadjSMK and SNPxSMK J models identified a total of 49 SNPs associated with BMI that reached GWS, including 15 novel loci. While no loci reached GWS for SNPxSMK on BMI, one novel SNPxSMK association with WC a near PRNP reached GWS in women. PRNP is highly expressed throughout the CNS and especially the hippocampus, as are many obesity-related genes. PRNP also plays a role in the body’s response to oxidative stress, making it a likely candidate gene for interaction with smoking as well. Of the GWS SNPs, 47 WC a and 41 BMI loci are nearby (&lt;500 kb) previously established loci for traits of interest (e.g. SMK, obesity, CVD, VAT, lipids, T2D, T1D and other anthropometrics). We identify one locus with strong evidence of interaction with SMK on obesity, and notably, we find several new loci associated with obesity by accounting for the influence of SMK. Our results highlight the importance of appropriately modeling genetic associations by considering known biological relationships between phenotypes and the environment.
Attacks on Health Increasing in Conflict-Ridden Countries
Authors: M. J. Friedrich
Journal: JAMA (2015)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Work-Related Illness, Injury
Authors: Joan Stephenson
Journal: JAMA (2005)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Pustular psoriasis precipitated by cytomegalovirus infection
Authors: K. Yoneda, Y. Matsuoka-Shirahige, T. Demitsu, Y. Kubota
Journal: British Journal of Dermatology (2012)

Journal Article Pustular psoriasis precipitated by cytomegalovirus infection Get access K. Yoneda, K. Yoneda Department of Dermatology, Faculty of Medicine, Kagawa University, 1750‐1 Ikenobe, Kitagun Mikicho, 761‐0793 Kagawa, Japan Search for other works by this author on: Oxford Academic Google Scholar Y. Matsuoka‐Shirahige, Y. Matsuoka‐Shirahige Department of Dermatology, Faculty of Medicine, Kagawa University, 1750‐1 Ikenobe, Kitagun Mikicho, 761‐0793 Kagawa, Japan Search for other works by this author on: Oxford Academic Google Scholar T. Demitsu, T. Demitsu Department of Dermatology, Jichi Medical University, Saitama Medical Center, Saitama, Japan E‐mail: kyoneda@med.kagawa‐u.ac.jp Search for other works by this author on: Oxford Academic Google Scholar Y. Kubota Y. Kubota Department of Dermatology, Faculty of Medicine, Kagawa University, 1750‐1 Ikenobe, Kitagun Mikicho, 761‐0793 Kagawa, Japan Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 167, Issue 5, 1 November 2012, Pages 1186–1189, https://doi.org/10.1111/j.1365-2133.2012.11044.x Published: 01 November 2012
Critically Ill Patients and Acute Renal Failure—Reply
Authors: Shigehiko Uchino, John A. Kellum, Rinaldo Bellomo
Journal: JAMA (2006)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Abstract 39: Fibroblast growth factor induces neoplastic cell transformation through a non-canonical signaling pathway
Authors: Sun-Mi Yoo, Cheol-Jung Lee, Mee-Hyun Lee, Yong-Yeon Cho
Journal: Cancer Research (2015)

Abstract Induction of cell proliferation is closely related with the cellular signaling pathway activation by stimulation of diverse growth factors such as epidermal growth factor (EGF) and fibroblast growth factor. The stimulation of growth factors induces activation of extracellular signal-regulated kinases (ERKs)/p90 ribosomal S6 kinases (p90RSK), resulting in induction of cell proliferation and cell transformation. Although fibroblast growth factor (FGF) is a well-known growth factor and acts as a ligand of FGF receptor (FGFR), a receptor tyrosine kinase, in cytoplasmic membrane, the tumor promoter potential has not been clearly understood. Here, we provided the evidences that FGF acted as a tumor promoter. We found that FGF-induced cell proliferation and anchorage-independent cell transformation were correlated with the induction of G1/S cell cycle transition. Importantly, we found that kaempferol targeted and inhibited FGFR phosphorylation by in vitro and ex vivo. Interestingly, FGF stimulation utilized a non-canonical signaling pathway to activate RSK2 and ATF-1, which was not transduced by EGF stimulation. We confirmed that kaempferol inhibited tyrosine phosphorylation of FGFR, resulted in nuclear accumulation of phospho-ATF-1 at Ser63. Importantly, kaempferol, PKC412, PD98059 and U0126 inhibited EGF-induced anchorage-independent cell transformation in JB6 Cl41 cells. In contrast, FGF-induced cell transformation in soft agar was not inhibited by PD98059 and U0126. Taken together, these results demonstrate that FGF acts as a tumor promoter and dual inhibition of kaempferol on the kinase activities of FGFR and RSK2 suppresses the FGF-induced neoplastic cell transformation through a non-canonical signaling pathway which is not utilized by EGF stimulation. Citation Format: Sun-Mi Yoo, Cheol-Jung Lee, Mee-Hyun Lee, Yong-Yeon Cho. Fibroblast growth factor induces neoplastic cell transformation through a non-canonical signaling pathway. [abstract]. In: Proceedings of the 106th Annual Meeting of the American Association for Cancer Research; 2015 Apr 18-22; Philadelphia, PA. Philadelphia (PA): AACR; Cancer Res 2015;75(15 Suppl):Abstract nr 39. doi:10.1158/1538-7445.AM2015-39
Abstract 20533: Gender and Race Differences in Patient Characteristics and Outcomes in 10,582 Hospitalizations for Takotsubo Cardiomyopathy
Authors: David P Kao, JoAnn Lindenfeld
Journal: Circulation (2014)

Introduction:  Takotsubo cardiomyopathy (TTCM) is characterized by acute, reversible left ventricular dysfunction in the absence of epicardial coronary artery occlusion. Because of its rarity, little is known about age, gender and race differences in patients with TTCM.   Objectives:  To describe gender and race differences in TTCM   Methods:  Deidentified hospital data from California, New York, New Jersey, Vermont, New Hampshire, West Virginia, and Colorado between 2006 and 2012 were harmonized, and hospital records reporting the ICD-9 code 429.83 (takotsubo cardiomyopathy) were analyzed. Demographics, comorbid conditions, and in-hospital outcomes including death and major adverse events (MAE) defined as death, mechanical ventilation, cardiac arrest, shock, or placement of intra-aortic balloon bump were stratified according to race and gender. Characteristics independently associated with death and MAEs were identified using multivariate logistic regression.   Results:  In total, 10,582 TTCM cases were identified including 1077 (11.4%) men and 8350 (88.6%) women (1155 not available). Where race was reported, 5960 (70.7%) were white, 1266 (15.0%) had African Ancestry (AA), 291 (2.7%) were Asian, 748 (7.1%) were Hispanic, and 162 (1.5%) were of other or mixed race. Women were significantly older than men (p   Conclusions:  There are significant gender- and race-based differences in patient characteristics and adverse outcomes in patients hospitalized with TTCM. Further study of these differences may yield insight into the pathophysiology of this increasingly recognized disorder.
Abstract 3548: Study of the tumor suppressive machinery of arsenic trioxide-induced glioblastoma multiforme inhibition via microRNA-182-Sestrin2 regulatory circuit
Authors: Liang-Ting Lin, Shih-Hwa Chiou, Yi-Jang Lee
Journal: Cancer Research (2014)

Abstract Glioblastoma multiforme (GBM) is classified the fourth grade of human glioma that indicates the most malignant brain tumor with poor five-year survival (5%). Accumulated evidence showed that GBM cells were resistant to various therapeutic strategies. Recently, use of arsenic trioxide (ATO) to induce apoptosis and to increase the radiosensitivity was reported for the benefit in treating GBMs. However, the responsible signaling cascades are still remain investigation. MicroRNA, a category of RNA interference, regulates its downstream genes post transcriptionally by binding to the 3′untraslated region (UTR) of its targets. In this study, we used S1 and S1R1 GBM cells which were derived from the primary and the recurrent lesion respectively. Firstly, we identified that an oncogenic microRNA, miR-182, was down-regulated after the treatment of ATO in both GBM cells. In addition, one of the miR-182 targeted coding genes, Sestrin 2 (SESN2), plays an important role in relieving intracellular oxidative stress and participates in TP53 tumor suppressive pathway. Use of luciferase-based reporter assay confirmed that miR-182 directly bound to SESN2 3′UTR and interrupted the further translation. Intriguingly, the basal level of miR-182 in the primary S1 GBM was significantly lower than the recurrent S1R1 GBM, supporting the oncogenic evidence in the previous studies. The counteracted SESN2 expression was also determined by real-time qPCR and western blot. We then hypothesized that ATO may retarded the growth of GBM through a miR-182-SESN2 related regulatory axis. Overexpression of miR-182 in S1 GBM resulted in a decrease of SESN2 and insensitive to ATO treatment. On the opposite, inhibition of miR-182 in S1R1 GBM dramatically retarded the growth rate and sensitized the cells to ATO. Moreover, pretreatment of an antioxidant, N-acetyl-cysteine (NAC), rescued the miR-182 suppression, suggesting that ATO-induced oxidative stress may be dominant in this responsive axis. Concordant expression of miR-182/96/182 cassette was revealed, indicating the transcriptional regulation was unveiled. Further investigation on the detailed machinery still remain elucidating. Based on our findings, we displayed that ATO-induced oxidative stress triggered a tumor suppressive response through a miR-182-SESN2 dependent machinery. Citation Format: Liang-Ting Lin, Shih-Hwa Chiou, Yi-Jang Lee. Study of the tumor suppressive machinery of arsenic trioxide-induced glioblastoma multiforme inhibition via microRNA-182-Sestrin2 regulatory circuit. [abstract]. In: Proceedings of the 105th Annual Meeting of the American Association for Cancer Research; 2014 Apr 5-9; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2014;74(19 Suppl):Abstract nr 3548. doi:10.1158/1538-7445.AM2014-3548
Abstract 4373: Integrated microRNA and mRNA signature associated with the transition from the locally confined to the metastasized renal cell carcinoma
Authors: Jean-Noel Billaud
Journal: Cancer Research (2014)

Abstract Background MicroRNAs (miRNAs) are endogenous small non-coding RNAs that regulate gene expression by interfering translation or stability of target transcripts. One miRNA can interact with several hundred mRNAs, while one mRNA can be regulated by several miRNAs. This interplay between miRNA and their mRNA has been proposed as an important process in cancer development and progression. We have investigated molecular networks impacted by predicted mRNA targets of differentially expressed miRNAs in patients with clear cell renal cell carcinoma (ccRCC) diagnosed with or without metastasis. Material and methods miRNA and mRNA microarray expression profiles derived from primary clear cell renal cell carcinomas from patients with (in total 16 samples) or without diagnosed metastasis (in total 22 samples) were used to identify anti-correlated miRNA-mRNA interaction in ccRCC. For this purpose, Ingenuity pathway analysis microRNA Target Filter, which enables prioritization of experimentally validated and predicted mRNA targets was used. By applying an expression pairing tool, the analysis was focused on targets exhibiting altered expression in our analysis, finding miRNAs and their target genes with opposite or same expression. The resulting identified interactions were revalidated by RT-qPCR in another cohort of RCC patients. The predicted miRNA-mRNA interactions were also tested by functional analyses using miRNA knock-down and over expression experiments in renal cancer cell lines. Results Among the significantly differentially expressed miRNAs, we have identified 3 miRNAs (miR-146a, miR-128a and miR-17-5p) that were upregulated in primary tumors from patients without metastasis and down regulated in primary tumors from patients with metastasis. We have further identified the mRNA targets which expression were inversely correlated to these 3 miRNAs, and have been previously experimentally demonstrated in cancer setting in humans. Specifically we showed that BRAC1, MCM10, CDKN3, UHRF1, IL8 were downregulated and targeted by miR-146a-5p. The relation between these identifies target genes and miRNA-146a was validated in cell culture experiments. Conclusions We identified novel target genes of dysregulated miRNAs, which are involved in the transition from primary RCC without metastases into tumors generating distant metastasis. Citation Format: Jean-Noel Billaud. Integrated microRNA and mRNA signature associated with the transition from the locally confined to the metastasized renal cell carcinoma. [abstract]. In: Proceedings of the 105th Annual Meeting of the American Association for Cancer Research; 2014 Apr 5-9; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2014;74(19 Suppl):Abstract nr 4373. doi:10.1158/1538-7445.AM2014-4373
Studies on an Enzyme in Human Serum Which Hydrolyzes Leucyl-β-Naphthylamide
Authors: William O'Connell, Richard J. Winzler
Journal: Cancer Research (1963)

A study of the activity of a serum enzyme or enzymes capable of hydrolyzing l-leucine-β-naphthylamide has shown that this enzyme (LNH) is not markedly elevated in patients with carcinoma of the breast and that the degree of progression of the disease bears no consistent relationship to the serum enzyme level. The enzyme was partially purified by chromatography on DEAE columns. The preparations so isolated were incapable of hydrolyzing other peptides at a significant rate. These data, along with variations in the ratios of leucine amino peptidase and LNH, indicate a degree of specificity for the enzyme which differentiates it from classical leucine amino peptidases.
Abstract 133: Electrical Insulating Gloves for Safe Hands-on Defibrillation Do Not Compromise the Quality of Chest Compressions
Authors: Jakob E Thomsen, Martin Harpsø, Graham W Petley, Svend Vittinghus, Charles D Deakin, Bo Løfgren
Journal: Circulation (2014)

Introduction: We have recently shown that Class 1 electrical insulating gloves are safe for hands-on defibrillation. Continuous chest compressions during defibrillation reduce the peri-shock pauses and increase the subsequent chance of successful defibrillation. In this study we have investigated the effect of these electrical insulation gloves on the quality of chest compressions, compared with normal clinical examination gloves. Methods: Emergency medical technicians trained in 2010 resuscitation guidelines delivered uninterrupted chest compressions for 6 min on a manikin, whilst wearing Class 1 electrical insulating gloves or clinical examination gloves. The order of gloves was randomized and each session of chest compressions was separated by at least 30 min to avoid fatigue. Data were collected from the manikin. Compression depth and compression rate were compared. Results: Data from 35 participants are shown in Figure 1. There was no statistically significant difference between Class 1 electrical insulating gloves in chest compression depth (median±range: 45 (28-61) vs 43 (28-61) p=0.69) and chest compression rate (113 (67-150) vs 113(72-145), p=0.87) when compared to clinical examination cloves. Conclusion: These preliminary data suggest that the use of Class 1 electrical insulation gloves does not reduce the quality of chest compressions during simulated CPR compared to clinical examination gloves.
Shuffling Mouse’s Genetic Deck May Illuminate Causes of Complex Diseases
Authors: Tracy Hampton
Journal: JAMA (2004)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
PET/CT in primary mediastinal large B-cell lymphoma responding to rituximab-CHOP: An analysis of 106 patients regarding prognostic significance and implications for subsequent radiotherapy
Authors: T P Vassilakopoulos, G A Pangalis, S Chatziioannou, S Papageorgiou, M K Angelopoulou, Z Galani, G Kourti, V Prassopoulos, T Leonidopoulou, E Terpos, M N Dimopoulou, S Sachanas, C Kalpadakis, P Konstantinidou, D Boutsis, E Stefanoudaki, L Kyriazopoulou, M P Siakantaris, M-C Kyrtsonis, E Variami, I Kotsianidis, A Symeonidis, E Michali, E Katodritou, G Kokkini, C Tsatalas, H Papadaki, M-A Dimopoulos, V Sotiropoulos, V Pappa, T Karmiris, J Meletis, J Apostolidis, I Datseris, P Panayiotidis, K Konstantopoulos, P Roussou, P Rondogianni
Journal: Leukemia (2015)