tbuckley/cabot-search huggingface dataset:
National surveillance for hemophilia inhibitors in the United States: Summary report of an expert meeting
Authors: J. Michael Soucie, Connie H. Miller, Fiona M. Kelly, Diane Aschman, Donna DiMichele, Barbara A. Konkle, Roshni Kulkarni, Paul E. Monahan
Journal: American Journal of Hematology (2014)

On March 12, 2012, the Centers for Disease Control and Prevention (CDC) held a meeting of its partners in hemophilia treatment, community-based organizations, industry, and government to review data and discuss implementation issues relevant to planned United States (U.S.) national inhibitor surveillance. Issues discussed included the current status of inhibitor surveillance in the United Kingdom (UK) and the US, the results of a US inhibitor surveillance feasibility study, proposed national surveillance schemes, laboratory testing and reporting issues and potential opportunities for future inhibitor-related research. It was concluded that implementation of a national program of inhibitor surveillance using standardized testing through an established public health registry along with patient and care provider education and targeted research provide the best opportunity to inform efforts to develop and evaluate effective prevention strategies.
Medical School Curricula
Authors: Tracy Hampton
Journal: JAMA (2004)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Sleep Apnea Guidelines
Authors: Rebecca Voelker
Journal: JAMA (1999)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Abstract 19074: Relationship Between Hospital Procedure Volume and Complications Following Congenital Cardiac Catheterization: a Report from the IMPACT® Registry
Authors: Andrew C Glatz, Natalie M Jayaram, Michael L O’Byrne, Yan Li, Paul S Chan, Praneet K Sharma, Lisa Bergersen, John A Spertus
Journal: Circulation (2014)

Background: The association between institutional procedural volume and outcomes has been demonstrated for many procedures within the field of cardiology, but whether this relationship pertains to congenital cardiac catheterization is unknown. Methods: Using the IMPACT® (Improving Pediatric and Adult Congenital Treatment) Registry, we identified all catheterizations between 2011 and 2013 at 64 U.S. centers. Programs were categorized as small (&lt;150 cases/year), medium (150 to 300 cases/year), large (300-500 cases/ year), and very large (&gt;500 cases/ year). Hierarchical logistic regression, adjusted for patient and procedural characteristics, was used to determine the association between annual procedural volume and occurrence of a major adverse event (cardiac arrest; arrhythmia requiring permanent pacemaker; tamponade; air embolus; embolic stroke; device malposition, thrombus, or embolization; new requirement for dialysis; event requiring extracorporeal membrane oxygenation or left ventricular assist device; unplanned cardiac, vascular, or other surgery; or subsequent cardiac catheterization). Results: Among 64 hospitals, there were 19 small, 15 medium, 19 large, and 11 very large programs. Among 33,825 catheterizations, a major adverse event occurred in 711 (2.1%). In unadjusted analysis, major adverse events differed based upon annual volume, with a major adverse event occurring in 79 (2.8%) cases at small, 145 (2.3%) cases at medium, 234 (2.1%) cases at large, and 253 (1.9%) cases at very-large programs (p=0.01). After adjusting for patient and procedural risk factors, there was no association between annual procedure volume and occurrence of a major adverse event (odds ratio 0.96 [95% Confidence Interval=0.90, 1.04] per increase in annual volume of 100, p=0.32). There was no interaction between procedure-type risk group and volume on outcomes (p=0.49). Conclusions: Although the unadjusted risk of adverse events was lower in centers performing more catheterizations for congenital heart disease, this association between center volume and outcomes did not persist after adjustment for patient and procedural case-mix. The hospital sample size and low event rate may have limited our ability to detect significant differences.
Overcoming food allergy through acquired tolerance conferred by transfer of Tregs in a murine model
Authors: H. Yamashita, K. Takahashi, H. Tanaka, H. Nagai, N. Inagaki
Journal: Allergy (2011)

To cite this article: Yamashita H, Takahashi K, Tanaka H, Nagai H, Inagaki N. Overcoming food allergy through acquired tolerance conferred by transfer of Tregs in a murine model. Allergy 2012; 67 : 201–209. Abstract Background: The number of food allergy patients is increasing. Some children outgrow their food allergies through tolerance, whereas others remain susceptible throughout their lives. We aimed to contribute to food allergy therapeutics by understanding induction of oral tolerance in a murine food allergy model. Methods: We modified an existing murine food allergy model by using ovalbumin (OVA) to induce oral tolerance, either by pretreating mice with OVA or by transferring mesenteric lymph node (MLN) cells or T cells derived from mice treated with OVA. Results: Pretreatment with OVA prevented food allergy, with complete suppression of OVA‐specific immunoglobulin (Ig)E and IgA antibody production and interleukin (IL)‐4, IL‐10, and IL‐9 mRNA expression. The proportion of regulatory T cells (Tregs) in MLN cells and expression of transforming growth factor‐β mRNA increased. In the transfer model, anaphylaxis secondary to OVA intake was suppressed by transfer of whole MLN cells and Tregs from OVA‐treated mice. However, OVA‐specific IgE and IgA expressions were partially attenuated by transfer of antigen‐specific and nonspecific Tregs, but not by whole MLN cells from OVA‐treated mice. In the Treg transfer model, IL‐4 and IL‐10 mRNA expression decreased, but IL‐9 mRNA expression increased. Conclusion: We concluded that oral tolerance for food antigens is induced in two ways: (i) by initial exposure to antigen, or inherent tolerance, and (ii) by transfer of Tregs, or acquired tolerance. Because food allergies occur when inherent tolerance is absent, understanding of acquired tolerance is important for the development of therapies for food allergy.
Gastric Acid–Suppressive Agents and Risk of
Authors: Tjeerd-Pieter van Staa, Frank de Vries, Hubert G M Leufkens
Journal: JAMA (2006)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Abstract 202: The Use of Bispectral Index EEG Monitoring as a Screening Tool for the Reliable Detection of Epileptic Activity in Post--Cardiac Arrest Patients
Authors: Jolien Haesen, Lien Desteghe, Ingrid Meex, Cornelia Genbrugge, Jelle Demeestere, Ludovic Ernon, Jo Dens, Cathy De Deyne
Journal: Circulation (2014)

Background: Assessment of prognosis in post[[Unable to Display Character: &amp;#8211;]]cardiac arrest (CA) patients became very challenging since the introduction of therapeutic hypothermia (TH). Continuous EEG monitoring has been proposed to improve prognostication; however, its use is limited due to difficulties in readily interpretation. This emerges the need for a simple EEG montage. The bispectral index (BIS) monitor is a simplified EEG system, mainly calculating an index ranging from 0 (isoelectric EEG) to 100 (full consciousness) to provide information on hypnotic depth of anesthesia. The aim of the study was to validate the accuracy of simplified EEG monitoring in a CA - setting. Methods: BIS monitoring (BIS VISTA TM ) was applied to collect frontotemporal data in TH-treated CA patients. A standard 19 [[Unable to Display Character: &amp;#8211;]] channel EEG was performed after return to normothermia. Afterwards, small EEG frames coincident with the time of full EEG registration were extracted from the BIS monitor. We asked 2 neurologists to indicate the presence of status epilepticus (SE), cerebral inactivity (CI), burst suppression (BS) or a diffuse slowing pattern (DS). In addition, these samples were analyzed by 2 inexperienced physicians, who were asked to indicate the presence of SE. Results: Thirty simplified EEG samples were analyzed. According to standard EEG, 11 patients showed a DS pattern, 3 had CI, 6 showed BS and 10 had an SE. Neurologists interpreted all samples with a high accuracy (sensitivity: 82% and specificity: 92%). Only 1 SE was missed by one neurologist. Interobserver reliability was high (kappa=0.843). High correlations were found for the comparison of full and simplified EEG for both neurologists (r=0.809). Further, the 2 inexperienced physicians identified SE with a sensitivity of 85% and specificity of 98%. Conclusion: Simplified EEG monitoring, using BIS, resulted in high accuracy of a simple classification system in post [[Unable to Display Character: &amp;#8211;]] CA patients. Not only neurologists, but also treating physicians were capable to identify SE, which may play an important role in the early detection of SE. We suggest using BIS as a screening tool in post [[Unable to Display Character: &amp;#8211;]] CA patients to save valuable time in the detection of SE, without replacing the need of full EEG monitoring for confirmation.
The Icelandic Cancer Project – a population-wide approach to studying cancer
Authors: Thorunn Rafnar, Steinunn Thorlacius, Eirikur Steingrimsson, Mikkel H. Schierup, Jesper N. Madsen, Violeta Calian, Bjarki J. Eldon, Thorvaldur Jonsson, Jotun Hein, Snorri S. Thorgeirsson
Journal: Nature reviews. Cancer (2004)
Abstract 457: Expression, purification, and characterization of recombinant TAT-SALL4B protein
Authors: Mengru Yuan, Yongping Jiang, Wei Dai
Journal: Cancer Research (2014)

Abstract SALL4 is an important transcription factor that supports expansion of hematopoietic stem cells. Several recent studies reveal that SALL4 and SALL4B (a major isoform) are heavily modified by post-translational mechanisms and that these modifications are critical for their stability, subcellular localization, and transcriptional activities. Given the importance of SALL4 and SAL4B in supporting stem cell self-renewal and expansion, we optimized a large scale expression and purification process to obtain SALL4B. Sf9 insect cells were transduced with the recombinant baculovirus expressing human SALL4B fused with 6His residues and a TAT sequence in the N-terminus. Recombinant TAT-SALL4B was purified by nickel affinity chromatography under native conditions. Immuno-blotting confirmed that recombinant SALL4B was highly expressed and purified. As the first step to test the biological activity of purified TAT-SALL4B, we investigated whether TAT-SALL4B, directly supplemented to the culture medium, was capable of entering into cells through the protein transduction process. Immuno-fluorescence microscopy revealed that recombinant TAT-SALL4B specifically localized to the nucleus in a concentration- and time-dependent manner. To further test the transcriptional activity of TAT-SALL4B protein, dual luciferase reporter assay was performed, which showed that TAT-SALL4B protein was transcriptionally active.Our results suggest that TAT-SALL4B may provide a promising cellular factor for supporting ex vivo expansion of hematopoietic stem cells. Citation Format: Mengru Yuan, Yongping Jiang, Wei Dai. Expression, purification, and characterization of recombinant TAT-SALL4B protein. [abstract]. In: Proceedings of the 105th Annual Meeting of the American Association for Cancer Research; 2014 Apr 5-9; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2014;74(19 Suppl):Abstract nr 457. doi:10.1158/1538-7445.AM2014-457
TREATMENT OF LOBAR PNEUMONIA BY ARTIFICIAL PNEUMOTHORAX
Authors: Fred G. Holmes, Howell Randolph
Journal: Annals of Internal Medicine (1935)

ExcerptLobar pneumonia may be considered to be an infectious (usually pneumococcic) lobar atelectasis of the lung. The work of Coryllos and Birnbaum1 and others has strengthened this conception of the disease. Thepneumococcic infection of the bronchus causes the formation of a very tenacious fibrin-containing sputum which may readily narrow or completely occlude a large bronchus. With the occlusion of the main bronchus to a lobe, lobar atelectasis takes place, beginning at the periphery where the greatest number of alveoli are found, and progressing toward the hilus, while there follows a pneumococcic cellulitis proceeding peripherally from the hilus abetted by...
Abstract 18730: Effects of Maternal Prenatal Psychosocial Stress on Early Childhood Hemodynamic Responses: A Chinese Experience
Authors: Fenling Fan, Yuliang Zou, Hongyan Tian, Yushun Zhang, Junbo Zhang, Xiancang Ma, Ya Liu, Yan Meng, Yafei Yue, Kai Liu, Anthony Dart
Journal: Circulation (2014)

Introduction:  Prenatal psychosocial stress (PPS) manifesting, as anxiety (PA) and/or depression (PD), is common during human pregnancy. There are few studies in humans on long-term consequences of such stress on offspring, particularly for the cardiovascular system.   Hypothesis:  Maternal PPS in pregnancy altered the stress response of healthy full-term offspring during early childhood.   Methods:  216 Chinese pregnant women (71, 72 and 73 during the first, second and third trimesters, respectively) underwent validated structured questionnaire-based PPS and serum cortisol level assessments. Offspring, were subjected to a 10-minute-video stress challenge at ages 7-9 years; resting and post-stress heart rate (rHR,sHR )and blood pressure (rBP, sBP) were measured.   Results:  The children of mothers who had experienced PPS, particularly anxiety, exhibited greater stress hemodynamic responses independently of child gender or pregnant trimesters (Table1 ).  There were significant bivariate correlations between maternal cortisol and children’s resting and stress hemodynamic parameters (all P  Multiple regression analyses were undertaken, separately for each trimester, with children’s hemodynamic responses as the dependent variable and including levels of PA and PD (absent, mild, moderate and severe), maternal cortisol and gender as independent variables. Effects of PA were more consistent (all P   Conclusion:  The results suggest a long-term influence of PA on the cardiovascular response to stress of their offspring, which might contribute to later development of cardiovascular disease later as has been documented for other prenatal influences.
Intractable breathlessness in COPD – A suitable case for palliation?
Authors: Patrick White, Sara Booth, Sofia Georgopoulou, Wai Yee James, Scott Murray, John Moxham, Hilary Pinnock, Paul Seed, Cathy Shipman, Irene Higginson, Hannah Thornton, Helen Booth
Journal: European Respiratory Journal (2011)

Introduction: Breathlessness is the major symptom of concern for people with advanced COPD. Intractable breathlessness may be described as “sustained severe breathlessness in patients who have not obtained relief from conventional treatment”. This study set out to define the prevalence of intractable breathlessness in COPD and potential for its palliation.

Method: COPD patient records in south London practices were searched for ≥2 of: FEV1 ≤30% predicted, hospital admissions/exacerbations needing oral steroids, long term O2, and cor pulmonale. Participants were interviewed at home. Breathlessness was assessed using MRC Dyspnoea, mBorg, NRS, Dypsnoea-12 and Chronic Respiratory Questionnaire. Intractable breathlessness was defined using a combination of FEV1% predicted, CRQ-Dyspnoea, Dyspnoea-12 and the desire for more help. Treatment optimisation was offered where appropriate before reassessment of breathlessness.

Results: 5102 patients were identified in 72 practices, 2163 had spirometry-confirmed COPD. 260 (5%) were eligible and 146 (56%) took part. 65% reported breathlessness as their most important problem, 69% reported breathlessness everyday and 59% reported needing more help for breathlessness. 69% scored 4-5 on MRC Dyspnoea Scale. 63 (43%) were on sub-optimal treatment, 97% of whom received optimisation. Improvements in breathlessness weren't observed at re-assessment. 29 (20%) participants had intractable breathlessness; an estimated 2% of patients with confirmed COPD in the study population.

Conclusion: Intractable breathlessness affects around 1 in 50 COPD patients on practice registers. Increased recognition of this problem and provision of specialist palliative services for these patients is a priority.
Mutations in GJB6 cause nonsyndromic autosomal dominant deafness at DFNA3 locus
Authors: Anna Grifa, Carsten A. Wagner, Lucrezia D'Ambrosio, Salvatore Melchionda, Francesco Bernardi, Nuria Lopez-Bigas, Raquel Rabionet, Mariona Arbones, Matteo Della Monica, Xavier Estivill, Leopoldo Zelante, Florian Lang, Paolo Gasparini
Journal: Nature Genetics (1999)
Abstract 2503: Differential expression of cytoskeletal proteins in acute lymphoblastic leukemia in accordance with initial response to chemotherapy
Authors: Kee R. Kang, Eun Sil Park
Journal: Cancer Research (2014)

Abstract Precursor B lymphoblastic leukemia is a B-cell lineage neoplasm of lymphoblasts. The initial response to induction-chemotherapy is the most important prognostic factor in acute lymphoblastic leukemia (ALL) patients. Patients with rapid-early-response (RER, below 5% of blast in bone marrow at day-7 after induction-chemotherapy) have better event-free survival compared to slow-early-responders (SER, above 25% of blast). The drug sensitivity/resistance of leukemic blasts is mainly determined by specific genetic abnormalities, however, in more than 20% of ALL, the abnormalities remain unclassified, and the treatment outcome persist variable. This study aimed to find plausible biomarkers of drug sensitivity/resistance in ALL using proteomic analysis. We identified 28 up-regulated and 25 down-regulated proteins in SER_as compared to RER_by MALDI-TOF and mass spectrometry. Of these, 14-3-3 isoforms and cytoskeletal proteins were differentially expressed. Alpha tubulin and 14-3-3 gamma, down-regulated in RER were further verified by Western blot analysis. In further studies, the roles of these proteins in drug sensitivity/resistance are undergoing to elucidate as a potential biomarker for ALL therapy. Citation Format: Kee R. Kang, Eun Sil Park. Differential expression of cytoskeletal proteins in acute lymphoblastic leukemia in accordance with initial response to chemotherapy. [abstract]. In: Proceedings of the 105th Annual Meeting of the American Association for Cancer Research; 2014 Apr 5-9; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2014;74(19 Suppl):Abstract nr 2503. doi:10.1158/1538-7445.AM2014-2503
Tobacco Epidemiology and the Challenge of Multiple Etiologies
Authors: David S. Jones, Allan M. Brandt
Journal: JAMA (1998)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal