tbuckley/cabot-search huggingface dataset:
Abstract 4733: p62/sequestosome 1, a potent prognostic factor, enhance cell proliferation in human colorectal carcinoma
Authors: Shun Nakayama, Takashi Suzuki, Shinichi Yabuuchi, Kiyoshi Takagi, Yoshiaki Onodera, Yasuhiro Nakamura, Mika Watanabe, Fumiyoshi Fujishima, Hiroshi Yoshida, Takanori Morikawa, Hideaki Karasawa, Tomohiko Sase, Takeshi Naitoh, Yu Katayose, Shinichi Egawa, Michiaki Unno, Hironobu Sasano
Journal: Cancer Research (2014)

Abstract p62/sequestosome 1 (p62) is a multi-domain protein implicated in the selective degradation of ubiquitinated protein by autophagy, and it also functions as a scaffold protein in cell signaling pathways. p62 was recently reported to be accumulated in several types of human cancer cells, but the clinical significance and biological roles of p62 have remained largely unknown in colorectal carcinoma. p62 immunoreactivity was examined in 118 surgical specimens of human colorectal carcinomas using immunohistochemistry. p62 immunoreactivity was detected in about one third of the carcinoma cases, while it was negligible in the adjacent non-neoplastic epithelium. The immunohistochemical p62 status was significantly associated with synchronous liver metastasis in the carcinoma cases, and multivariate analysis further revealed the p62 status as an independent adverse prognostic factor for overall survival in the patients. We used 4 colon carcinoma cells in the in vitro studies to evaluate the functional roles of p62. The colon carcinoma cells transfected with p62-specific small interfering RNAs showed significantly decreased cell proliferation activities, and the colon carcinoma cells transfected with p62 expression plasmid showed significantly increased the cell proliferation activity. Results of in vitro studies indicated that p62 significantly promoted the cell proliferation of colorectal carcinoma cells, but the autophagic activity was not linked to the p62-mediated cell proliferation. These findings suggest that p62 promotes the proliferation of colon carcinoma cells mainly as a scaffold protein. The p62 status is a potent prognostic factor in human colorectal cancer patients, and could be an important specific therapeutic target of colorectal carcinoma that could improve the clinical outcome in the future. Citation Format: Shun Nakayama, Takashi Suzuki, Shinichi Yabuuchi, Kiyoshi Takagi, Yoshiaki Onodera, Yasuhiro Nakamura, Mika Watanabe, Fumiyoshi Fujishima, Hiroshi Yoshida, Takanori Morikawa, Hideaki Karasawa, Tomohiko Sase, Takeshi Naitoh, Yu Katayose, Shinichi Egawa, Michiaki Unno, Hironobu Sasano. p62/sequestosome 1, a potent prognostic factor, enhance cell proliferation in human colorectal carcinoma. [abstract]. In: Proceedings of the 105th Annual Meeting of the American Association for Cancer Research; 2014 Apr 5-9; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2014;74(19 Suppl):Abstract nr 4733. doi:10.1158/1538-7445.AM2014-4733
Salem F Al-Damluji
Authors: S. Al-Damluji
Journal: BMJ (2001)

Former professor of medicine Baghdad University Medical College, Iraq (b 1924; q Baghdad 1946; FRCP), died from adenocarcinoma of the lung on 16 September 2001.


He was awarded the MD for a thesis on the treatment of heavy metal poisoning. After studying internal medicine and respiratory diseases in the United States, he returned to Baghdad and became a leader in respiratory medicine. He was the founding president of the Iraqi Cardiothoracic Society. His contributions also included 



studies on patients exposed to methyl mercury poisoning during an outbreak in 1961, and, more extensively, in 1971. He and his colleagues showed that the clinical features were partially reversible in patients who survived the initial, catastrophic effects of poisoning. He was chairman of the Department of Medicine in the University of Baghdad (1971-5). He established, in cooperation with the Royal College of Physicians of London, courses that prepared postgraduate doctors for the MRCP examinations. He moved to the United Arab Emirates in 1980. Predeceased by his wife, he leaves three children.
A CASE OF FATAL HEMOLYSIS FOLLOWING DIRECT TRANSFUSION OF BLOOD BY ARTERIOVENOUS ANASTOMOSIS.
Authors: WILLIAM PEPPER
Journal: JAMA (1907)

reference to the card can be determined by trial in a few seconds, but it is also interesting to work out the problem mathematically and see how nearly theory will check up with practice.To determine the proper position of the reflector by caculation, a curve of equal illu- mination is plotted for the reflector, as proposed by Mr. E. C. White2 in a paper on "Application of Photometric Data to Indoor Illumination."Let us take the righthand side of the dotted curved line in Pig. 3. Pig. 4 is a polar coordinate curve in which the distance from the center represents the distance in feet at which an even illumination in foot candles would be produced by a reflector giving a photometric curve, such as is shown in Pig. 3. The plotting of such a curve is a simple matter when we have the photometric curve as a basis, since the equal illumination curve is determined by op the formula d = </•-where d equals the distance in feet of the surface illuminated from the source of Flg. 5.-Sketch showing reflector In position on wall in its re- lation to test type.the light, cp equals the candle power of the ray, and I equals the illumination in foot candles.If I is taken as a constant quantity, then d = y/ cp and the equal illumination curve represents simply the square root values of the photometric curve.Pig. 4 is plotted on a scale which gives the distances in feet from the lamp at which a uniform illumination of 3 foot candles, this
Abstract 2846: Pigment epithelium-derived factor (PEDF) functions as a brain metastasis suppressor of breast cancer
Authors: Daniel P. Fitzgerald, Diane Palmieri, Yongzhen Qian, Monika Deshpande, Pretti Subramanian, Christian Graves, Sean Davis, Paul Meltzer, Kevin Camphausen, Patricia S. Becerra, Patricia S. Steeg
Journal: Cancer Research (2011)

Abstract Brain metastases occur in 10-20% of metastatic breast cancer patients. The one year survival rate is approximately 20%. Brain metastasis is typically diagnosed late in breast cancer progression; however, studies suggest that the incidence of brain metastasis may be increasing under current chemotherapeutic regimens. We have investigated changes in gene expression associated with the acquisition of brain metastatic potential by breast cancer. A DNA microarray analysis comparing human brain metastases and a cohort of unlinked primary breast carcinomas identified Pigment Epithelium-Derived Factor (PEDF) as down-regulated in the brain metastases relative to the primary tumors (mean ∼14X lower by QPCR validation). The data suggest the hypothesis that PEDF may have a negative impact on brain metastatic progression. PEDF, a secreted factor, has been shown to act as a tumor suppressor, has strong anti-angiogenic activity, but supports the proliferation/viability/ differentiation of neural tissue. We hypothesize that the multiple roles of PEDF make it a potent agent which targets not only tumor cells, but also the microenvironment of the brain. In vitro experiments demonstrated that PEDF can promote death of breast cancer cells. Conversely, PEDF promoted neuronal survival, in vitro. In a xenograft model system (231BR, a brain-tropic derivative of human MDA-MB-231 breast cancer cells) PEDF overexpression inhibited formation of large brain metastases (∼2-fold, p=0.001) and reduced proliferation of PEDF-expressing breast cancer cells in mouse brain metastases (11% Ki67-positive, PEDF-positive vs. &amp;gt;56% Ki67-positive, PEDF-negative). In an intracranial implantation model, expression of PEDF by breast cancer cells lead to a rapid reduction in brain metastatic tumor volume. Histological examination suggests that PEDF reduces gliosis and protects neurons concomitant to suppression of metastatic growth. The data suggest the intriguing possibility that PEDF overexpression may concurrently inhibit brain metastasis of breast cancer cells but preserve neuronal function. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 102nd Annual Meeting of the American Association for Cancer Research; 2011 Apr 2-6; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2011;71(8 Suppl):Abstract nr 2846. doi:10.1158/1538-7445.AM2011-2846
Differential distribution of a PEGylated Fab' into inflamed versus normal tissue compared with an IgG in arthritis and colitis models
Authors: M Marenzana, A Eddleston, A Vugler, A Nesbitt
Journal: Annals of the Rheumatic Diseases (2010)

Purpose Certolizumab pegol (CZP), a PEGylated Fab′, has been shown to distribute to infl amed versus normal tissue at a ratio of 3.8 in a collagen-induced arthritis (CIA) mouse model, whereas adalimumab (ADA), an IgG, had a ratio of 1.9. 1 The objective of this study was to compare PEGylated Fab′ and IgG distribution by determining the consequence of tumour necrosis factor (TNF) binding on the distribution of these reagents in infl amed versus normal tissue in the CIA and DSS gut colitis models.Methods An anti-mouse TNF antibody with an affi nity for mouse TNF, similar to the anti-human reagents CZP and ADA, was used for this study.Both the PEGylated Fab′ and IgG2a versions of this antibody were labelled with one of two fl uorescent dyes: Alexa 680 (CIA model) and Alexa 790 (DSS model).The reagents were given intravenously at 2 mg/kg in the CIA model and subcutaneously at 10 mg/kg in the DSS model.In both models, control animals were similarly dosed.In the CIA model, paws were imaged in vivo at various time points up to 26 h post-administration using an IVIS imager.In the DSS model, the colons were removed after 24 h and imaged using the IVIS imager ex vivo by drawing a region of interest around the whole excised colon.Results Both the IgG and PEGylated Fab′ penetrated infl amed tissue more effectively than the non-infl amed tissue in both the CIA and DSS models.However, in both models the ratio of distribution in infl amed versus normal tissue was higher for the PEGylated Fab′ than the IgG.In the CIA model, the ratio was 2.3 for the PEGylated Fab′ vs 1.7 for the IgG after 1 h (p=01 by unpaired two-tailed t test); the ratio remained signifi cant at all time points tested out to 26 h.In the DSS model, the ratio was 3.1 vs 2.1, respectively, after 26 h (p=0.02).Conclusions PEGylated Fab′ had a higher infl amed to normal tissue ratio than the IgG in two different mouse models of infl ammation.This confi rms previous observations concerning the effect of PEG on the distribution of proteins and suggests that antigen binding does not greatly affect distribution.
Patient education is way to influence maternal requests for caesarean section
Authors: L. M. Irvine
Journal: BMJ (1999)

EDITOR—The issue of whether women who decide to have elective caesarean section should pay for it raises several important points That women request elective caesarean section for maternal rather that obstetric reasons has a considerable cost implication: at Watford General Hospital it accounted for at least 38% of all elective deliveries by caesarean section over one year.1 The reasons for such requests may in part be due to heightened public awareness and publications such as the General Medical Council's Duties of …
Risk of idiopathic cerebral haemorrhage in women on oral contraceptives with differing progestagen components
Authors: Susan S Jick, Marian W Myers, Hershel Jick
Journal: The Lancet (1999)

The risk of idiopathic cerebral haemorrhage in users of third-generation oral contraceptives compared with that of users of second-generation oral contraceptives was evaluated using data from the General Practice Research Database. We found no increased risk for third-generation oral contraceptives, compared with second-generation oral contraceptives.
Abstract 5660: Cell-free generation and characterization of ErbB2-nanoparticle conjugates.
Authors: Wei He, Matthew Saldana, Tiffany Scharadin, Candice Gellner, Yuanpei Li, Kit Lam, Kermit Carraway, Paul Henderson, Matthew Coleman
Journal: Cancer Research (2013)

Abstract We have developed a rapid process for cell-free production of full-length ErbB2, a receptor tyrosine kinase that contributes to the onset and progression of breast and other tumor types. The receptor is solubilized and stabilized via incorporation into nanolipoprotein particles (NLPs). NLPs are discoidal structures, approximately 20 nm in diameter, that arise from the self-assembly of apolipoproteins around a phospholipid bilayer that acts as a mimic of the cell membrane. The ErbB2-NLP complex was soluble and could be recognized by antibodies, such as Trastuzumab, that indicate the presence of correctly folded ErbB2 extracellular domains. Kinase function was confirmed using Lapatinib, which inhibited tyrosine autophosphorylation during cell-free synthesis. The cell-free synthesis and biochemical characterization data support the potential use of ErbB2-NLPs and related variants for novel biochemistry and drug screening studies. Citation Format: Wei He, Matthew Saldana, Tiffany Scharadin, Candice Gellner, Yuanpei Li, Kit Lam, Kermit Carraway, Paul Henderson, Matthew Coleman. Cell-free generation and characterization of ErbB2-nanoparticle conjugates. [abstract]. In: Proceedings of the 104th Annual Meeting of the American Association for Cancer Research; 2013 Apr 6-10; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2013;73(8 Suppl):Abstract nr 5660. doi:10.1158/1538-7445.AM2013-5660
Self-Reported Long Total Sleep Duration Is Associated With Metabolic Syndrome
Authors: Teresa Arora, Chao Qiang Jiang, G. Neil Thomas, Kin-bong Hubert Lam, Wei Sen Zhang, Kar Keung Cheng, Tai Hing Lam, Shahrad Taheri
Journal: Diabetes Care (2011)

To examine the association between total sleep duration and the prevalence of metabolic syndrome (MetSyn) in older Chinese.Cross-sectional analysis of baseline data from the Guangzhou Biobank Cohort Study (GBCS) was performed. Participants (n = 29,333) were aged ≥50 years. Risk of MetSyn and its components were identified for self-reported total sleep duration.Participants reporting long (≥9 h) and short (<6 h) total sleep duration had increased odds ratio (OR) of 1.18 (95% CI 1.07-1.30) and 1.14 (1.05-1.24) for the presence of MetSyn, respectively. The relationship remained in long sleepers (OR 1.21 [1.10-1.34]) but diminished in short sleepers (0.97 [0.88-1.06]) after full adjustment.Long sleep duration was associated with greater risk of MetSyn in older Chinese. Confirmation through longitudinal studies is needed. The mechanisms mediating the link between long sleep duration and MetSyn require further investigation.
1105-175 Incidence of malignant ventricular tachycardia in patients with prophylactic defibrillator implantation does not differ from event rates in patients treated for survived cardiac arrest
Authors: Ulrich Backenkohler, Ali Erdogan, Mary-Kay Steen-Muller, Klaus Nehmer, Wilhelm Stertmann, Bernd Waldecker, Harald Tillmanns
Journal: Journal of the American College of Cardiology (2004)
1013-110 Effects of Cocaine on Human Platelet Aggregation In Vivo
Authors: Christian M. Heesch, Brian H. Negus, Manfred Steiner, Richard W. Snyder, Donald D. Mclntire, Paul A. Grayburn, Joy Ashcraft, José A. Hernández, Eric J. Eichhorn
Journal: Journal of the American College of Cardiology (1995)
Reverse Targeting of Preventive Care due to Lack of Health Insurance
Authors: Steffie Woolhandler
Journal: JAMA (1988)

We analyzed patterns of receipt of preventive services among middle-aged women, with particular attention to health insurance coverage, based on data from the National Health Interview Survey. Lack of insurance was most prevalent among socioeconomically disadvantaged women at high risk for disease and was the strongest predictor of failure to receive screening tests. The relative risk of inadequate screening for uninsured compared with insured women was 1.60 (95% confidence interval [Cl], 1.40 to 1.83) for blood pressure checkups, 1.55 (95% Cl, 1.43 to 1.68) for cervical smears, 1.52 (95% Cl, 1.41 to 1.63) for glaucoma testing, and 1.42 (95% Cl, 1.33 to 1.51) for clinical breast examination. Controlling for demographic and health status variables did not diminish the effect of insurance coverage. We conclude that inadequate insurance coverage leads to "reverse targeting" of preventive care--that is, populations at highest risk are least likely to be screened. This compromises both the effectiveness and the cost-effectiveness of screening.
Receptors for Peptide Hormones
Authors: C. RONALD KAHN
Journal: Annals of Internal Medicine (1977)

The first step in the action of polypeptide hormones and many neurotransmitters is binding to receptor sites on the plasma membrane of the cell. These receptors are usually complex, high molecular weight proteins. Using a variety of receptor preparations and radioactively labeled hormones, radioreceptor assays for several hormones have been developed. These have allowed for assay of hormones for which no immunoassay exists. Such assays have shown increased levels of NSILA-s (an insulin-like peptide) in patients with nonpancreatic tumors and hypoglycemia. In disease states, the number or affinity of hormone receptors may be altered, leading to hormone resistant states such as the insulin resistance of obesity. A major factor regulating receptor concentration is the hormone itself. Several hormones seem to accelerate inactivation of their own receptors. Antibodies to membrane receptors are produced in at least three diseases and cause hormone resistance or mimic states of hormone excess.
Low-Osmolar Contrast Agents
Authors: William A. Anthony
Journal: JAMA (1989)

To the Editor.—  I have two observations concerning the article entitled  Introduction of Low-Osmolar Contrast Agents in Radiology by Mr Jacobson and Dr Rosenquist 1 in the September 16 issue ofThe Journaland the accompanying editorial 2 : The projected saving of $1 billion is based on using the contrast media in only 15% to 20% of the patients. I doubt very much that only 15% to 20% of the patients fall into the long list of high-risk patients on page 1588 of the article (ie, infants, elderly patients, diabetic patients, patients with a history of allergy, patients with asthma, patients with a history of reaction to previous contrast media, and patients with renal or cardiac disease). Particularly if you include patients with a history of allergy, you will place the vast majority of patients in the high-risk category, thereby reducing the saving considerably.  Second, the article and the
PTU-161 Endoscopic Bougie Dilatation Is Effective And Safe For Oes Ophageal And Pharyngeal Strictures: Outcomes Of A Large Case Series
Authors: MR Smith, B Drinkwater, M Widlak, NC Fisher
Journal: Gut (2014)

<h3>Introduction</h3> Endoscopic bougie dilatation is a traditional technique for managing oesophageal strictures. There are some safety concerns with this technique, but no corroborative evidence of this in controlled or uncontrolled studies to date. <h3>Methods</h3> We evaluated the outcomes and safety of endoscopic bougie dilatation at our centre, using the endoscopy database to identify all dilatations done by a single operator. Bougies were the preferred option for all dilatations. All cases from January 2007 to March 2013 were then reviewed by case note analysis. <h3>Results</h3> 146 patients were identified, who underwent a total of 346 bougie dilatations. Median age was 67 yrs (range 27–91). Indications for dilatation were: peptic stricture 80 (55%), malignant stricture 20 (14%), post-surgical stricture 12 (8%), pharyngeal pathology 25 (17%) and other 9 (6%). Pharyngeal pathology was predominantly post-radiotherapy strictures (64%) and neurological (20%). In cases of peptic stricture, 78/80 (98%) had a good symptomatic response to an initial course of dilatation (requiring 1 procedure only in 82%). Median end dilatation diameter was 17 mm (range 12–18). Recurrence requiring further dilatation occurred in 27 (34%), after a median of 8 months (range 3–47). In the remainder, median observed remission was 24 months (range 1–63). For pharyngeal pathology patients underwent a median of 2 dilatations (range 1–12). After initial dilatation, 12 (48%) achieved lasting benefit, 5 (20%) had no benefit and 8 (32%) benefited from periodic scheduled dilatations. Overall median follow up was 22 months (IQR 7- 48). Among the whole case series there were 6 (4%) unscheduled admissions, all self-limiting (dysphagia 2, food bolus 2, stent-related bleed 1, pain 1). There were no perforations. <h3>Conclusion</h3> This large case series supports the role of bougie dilatation as a safe and effective therapy for benign peptic strictures. With careful case selection it also appears a valuable, appropriate and safe option for a range of similar oesophageal and pharyngeal pathologies. <h3>Disclosure of Interest</h3> None Declared.
New Breath Test for Bile Acid Deconjugation
Authors: Alan F. Hofmann, Hans Fromm
Journal: New England Journal of Medicine (1971)

Bile acids are secreted from the liver as conjugates with glycine and taurine, and, in health, the majority of the bile acid pool is absorbed from the ileum without bacterial deconjugation. In conditions of stasis, when bacteria proliferate in the small intestine, or of ileal disease or resection, when bile acids are poorly absorbed and pass into the colon, increased deconjugation occurs. The article by Sherr et al. in this issue (page 656), as well as a recent report from our own group,1 describes a simple test for altered bile acid metabolism, which measures the extent of bile acid deconjugation. . . .
Death following Injection of Neostigmine
Authors: R. R. Macintosh
Journal: BMJ (1949)

including the viruses of lymphogranulo'ma inguinale, psittacosis, and primary atypical pneumonia, the rickettsias, the enteric, Brucella, and relapsing-fever organisms, as well as -a large number of others.It is therapeutically effective after being given orally, but as it rapidly disappears from the blood frequent doses or high intermittent doses seem required; therapeutic dosage appears free from toxic or undesirable side-effects on man (Ley et al., 1948).As in the present case, positive stool cultures may occasionally be found in typhoid after a course of chloro- mycetin, and sometimes relapses with positive blood cul- tures may occur.Such relapses seem to respond readily to further courses of the drug, and no evidence that the organism becomes resistant has yet been reported.