tbuckley/cabot-search huggingface dataset:
Mutations in the Hereditary Hemochromatosis Gene Are Not Associated With the Increased Body Iron Stores Observed in Overweight and Obese Women With Polycystic Ovary Syndrome
Authors: José I. Botella-Carretero, Manuel Luque-Ramírez, Francisco Álvarez-Blasco, José L. San Millán, Héctor F. Escobar-Morreale
Journal: Diabetes Care (2006)

We recently reported (1) that serum ferritin levels are increased in overweight and obese women with polycystic ovary syndrome (PCOS) independently of inflammation. This finding suggested increased body iron stores in these women, raising the possibility that genes related to iron metabolism are altered in PCOS.

Classic hereditary hemochromatosis is an autosomal recessive disorder caused by mutations in the HFE gene, resulting in increased intestinal iron absorption and iron accumulation in several organs. In the study by Sanchez et al. (2), >80% of the Spanish patients with hereditary hemochromatosis were homozygous for the HFE C282Y mutation or compound heterozygotes for the HFE C282Y and …
Role of childhood infection in the sequelae of<i>H. pylori</i>disease
Authors: Paul R Harris, Lesley E Smythies, Phillip D Smith, Guillermo I Perez-Perez
Journal: Gut Microbes (2013)

The persistence of Helicobacter pylori infection plays a fundamental role in the development of H. pylori-associated complications. Since the majority of infected persons acquire the bacteria during early childhood, an examination of the immunobiology of H. pylori infection in children compared with that of adults may help identify host factors that contribute to persistent infection. Therefore, we begin our review of the role of persistence in H. pylori disease with an assessment of the clinical features of H. pylori infection in children. We next review the bacterial factors that promote colonization and evasion of host defense mechanisms. We then focus our attention on the early host immunological factors that promote persistence of the infection and its complications in humans and mouse models. We also highlight topics in which further research is needed. An examination of how immunological factors cause divergent manifestations of H. pylori infection in children compared with adults may provide new insight for therapeutic modification or prevention of persistent H. pylori infection and its complications.
Association of Symptoms of Type 2 Diabetic Patients With Severity of Disease, Obesity, and Blood Pressure
Authors: Christopher J Bulpitt, Alison J Palmer, Clare Battersby, Astrid E Fletcher
Journal: Diabetes Care (1998)

The symptoms of 430 type 2 diabetic patients were determined by a self-administered questionnaire before entry into the U.K. Prospective Diabetes Study.Entry into the trial followed 2 months of dietary treatment for newly diagnosed patients with type 2 diabetes. Forty symptoms with five levels of severity were included in the questionnaire. A complaint rate was computed as the sum of symptom scores divided by the number of symptom questions answered.The complaint rate was independently and positively related to BMI, fasting plasma glucose (FPG), and being a woman. Three symptoms--presence of dry mouth (P < 0.001), thirst (P < 0.01), and stomach pain (P = 0.02)--were related to FPG independent of sex, age, BMI, or blood pressure. Only dry mouth was related to HbA1c (P = 0.05). Complaints of shortness of breath, swollen ankles, headaches, heartburn, sweating, wheezing, nocturia, thirst, and diarrhea increased with BMI independently of other variables. A complaint of cold extremities decreased with BMI. Heartburn, weakness of limbs, and hot flushes were positively related to blood pressure, and unsteadiness was negatively related.The symptoms reported by patients with type 2 diabetes increased with FPG and markedly with BMI. The symptoms associated with obesity have been underestimated in the past.
Russell G. Witwer, MD
Authors: Phil Gunby
Journal: JAMA (1993)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Single-component self-assembled RNAi nanoparticles functionalized with tumor-targeting iNGR delivering abundant siRNA for efficient glioma therapy
Authors: Sai An, Xutao Jiang, Jiashu Shi, Xi He, Jianfeng Li, Yubo Guo, Yu Zhang, Haojun Ma, Yifei Lu, Chen Jiang
Journal: Biomaterials (2015)
Letter: Amitriptyline and imipramine poisoning in children.
Authors: R J Postlethwaite, D A Price
Journal: BMJ (1974)

Some intrauterine devices are easily seen on a plain x-ray.The Dalkon Shield, however, has a lower level of radio-ovacity, and unless certain x-ray techniques are used the device may be difficult or impossible to see.The radio-opacity is achieved by the addition of barium sulphate, which has the undesirable effect of rendering the device more brittle To enable the Dalkon Shield to be bent during insertion through the cervical canal it must be as thin and as pliable as possible, and the concentration of barium sul,phate is therefore kept lower than in other devices.Three techniques for the radiographic location of the Dalkon Shield are suggested for the average-sized patient: (1) "Regular" technique: machine setting 200 mA, 76 kV, 3/5 sec.(2) "Soft-tissue" technique A: machine setting 200 mA, 76 kV, 1/2 sec.(3) "Soft-tissue" technique B: machine setting 200 mA, 70 kV, 2/5-1/2 sec.We would recommend the use of one of the above radiological techniaues should radio- graphic location of a Dalkon Shield be required.-Weare, etc.,
Lung tissue volume estimated by simultaneous radiographic and helium dilution methods.
Authors: J D Armstrong, E H Gluck, R O Crapo, H A Jones, J M Hughes
Journal: Thorax (1982)

The pulmonary total tissue volume (blood, extravascular water, and dry tissue volume) was measured by finding the difference between the radiographic displacement volume of the thorax (RDVT) and the lung gas volume. Simultaneous determinations of RDVT and gas volume were made in 10 healthy subjects sitting upright. RDVT was determined from posteroanterior and lateral chest radiographs, a computerised modification of the Barnhard method being used; and gas volume was measured by helium dilution with each radiographic exposure. At functional residual capacity pulmonary total tissue volume was 843 +/- 110 ml (1 SD). The density of the lung (ml tissue per ml tissue and gas) was 0.19 +/- 0.03 (1 SD). This method, different in principle from indicator-dilution and acetylene rebreathing studies, provides measurements of total tissue volume.
Chronic Kidney Disease Causes Defects in Signaling through the Insulin Receptor Substrate/Phosphatidylinositol 3-Kinase/Akt Pathway
Authors: James L. Bailey, Bin Zheng, Zhaoyong Hu, S. Russ Price, William E. Mitch
Journal: Journal of the American Society of Nephrology (2006)

Complications of chronic kidney disease (CKD) include depressed responses to insulin/IGF-1 and accelerated muscle proteolysis as a result of activation of caspase-3 and the ubiquitin-proteasome system. Experimentally, proteolysis in muscle cells occurs when there is suppression of phosphatidylinositol 3-kinase (PI3-K) activity. Postreceptor signaling through the insulin receptor substrate (IRS)/PI3-K/Akt pathway was evaluated in muscles of acidotic, CKD and pair-fed control rats under physiologic conditions and in response to a dose of insulin that quickly stimulated the pathway. Basal IRS-1–associated PI3-K activity was suppressed by CKD; IRS-2–associated PI3-K activity was increased. The basal level of activated Akt in CKD muscles also was low, indicating that the higher IRS-2–associated PI3-K activity did not compensate for the reduced IRS-1–associated PI3-K activity. Insulin treatment overcame this abnormality. The low IRS-1–associated PI3-K activity in muscle was not due to a decrease in IRS-1 protein, but there was a higher amount of the PI3-K p85 subunit protein without a concomitant increase in the p110 catalytic subunit, offering a potential explanation for the lower IRS-1–associated PI3-K activity. Eliminating the acidosis of CKD partially corrected the decrease in basal IRS-1–associated PI3-K activity and protein degradation in muscle. It is concluded that in CKD, acidosis and an increase in the PI3-K p85 subunit are mechanisms that contribute to suppression of PI3-K activity in muscle, and this leads to accelerated muscle proteolysis.
The Bactericidal Values of Some Widely Advertised Antiseptics.
Authors: E. G. Swift
Journal: JAMA (1907)

Detroit, July 10, 1907. <h3>To the Editor:</h3> —InThe Journalof the American Medical Association, June 29, there appears an article with the above title by F. H. Verhoeff, M.D., and Edward Keith Ellis, M.D., Boston. In our opinion the article is unscientific; it gives a false impression as to the value of the antiseptics tested and places the manufacturers of these antiseptics in a false light. The only conclusion that a reader of the article, not versed in the testing of antiseptics, could draw would be that the manufacturers have made false claims for their preparations. Had the title of the article been: "The Bactericidal Values of Some Widely Advertised Antiseptics Under Certain Conditions," less fault could have been found with it. It is a matter of common knowledge to those who have given thought to the testing of antiseptics and germicides that under certain conditions they are relatively
Seasonal allergic rhinitis and depot injection of a corticosteroid
Authors: P. Borum, H. Grønborg, N. Mygind
Journal: Allergy (1987)

It was the aim of this investigation to study the efficacy of a corticosteroid given as a depot injection in seasonal allergic rhinitis, the efficacy profile with regard to specific symptoms, and whether the injection is best given early in the season or later at the peak of the pollen count. An injection of 80 mg methylprednisolone showed a marked effect on nasal blockage lasting more than 4 weeks, and a moderate effect on eye symptoms, while the effect on nasal hypersecretion and sneezing could not be demonstrated. It is concluded that systemic corticosteroids may be indicated in severe hay fever, when symptoms, especially blockage, occur in spite of other types of therapy. If the physician prefers to give the corticosteroid as a depot injection, it is preferably given in the first half of the season when the pollen count is increasing.
PWE-074 How Often do we Discontinue Maintenance Infliximab Due to Clinical Remission In Crohn’S Disease?
Authors: J P Seenan, J Munro, S Laird, J W Winter, D R Gaya, J Morris
Journal: Gut (2013)

<h3>Introduction</h3> Biologics are increasingly used in the management of Crohn’s disease (CD). NICE guidelines advise reassessing CD patients after 12 months of treatment with infliximab and discontinuing therapy for patients in stable clinical remission. Evidence suggests that sustained remission may be achieved in up to 50–60% of these patients on withdrawal of treatment. However, it is recognised that decisions regarding continuing treatment must be individualised and take into account previous disease behaviour. We sought to determine how often in clinical practise maintenance infliximab was discontinued due to clinical remission. <h3>Methods</h3> All patients treated with infliximab for CD between September 2006 and December 2012 were identified from our inflammatory bowel disease (IBD) database. Dates of initiation and termination of treatment were recorded along with the reason for discontinuation. Patients continuing on infliximab were analysed in more detail. Patient demographics, past medical history, Montreal classification, baseline investigations, Harvey-Bradshaw index (HBI) and faecal calprotectin (FC) levels were recorded. <h3>Results</h3> 114 patients were identified. 11 patients transferred care and were excluded. 91/103 (88.3%) received maintenance (&gt;6 weeks) treatment. 47.3% had discontinued treatment while 52.7% remained on treatment. The median length of treatment was 73 (range 8–329) weeks. Only 23.3% (10/43) discontinued infliximab due to clinical remision with 34.9% (15/43) stopping because of complications and 39.5% (17/43) due to loss of response, surgery or death. The median course of treatment for those continuing on infliximab was 101 (range 8–329) weeks. 37 patients (21 female, mean age 40 years) were on maintenance infliximab treatment for over 1 year. 73% of these patients were on combined treatment with an immunomodulator and 37.8% (14/37) had required dose escalation or a reduction in dose interval. In patients continuing treatment for over 1 year, the median FC was 184µg/g (range 30–9000) with a median reduction in FC level post-treatment of 416µg/g (range –3000–7086) and a median HBI of 4 (range 0–16). 57.1% could be defined as being in clinical remission with HBI &lt; 5. <h3>Conclusion</h3> In our large cohort of CD patients, few patients discontinued infliximab due to clinical remission. In those continuing infliximab for over 1 year the median FC was low, suggesting good control of inflammation, and the majority of patients were in clinical remission as defined by a HBI &lt; 5. These results support the efficacy of infliximab as maintenance therapy in CD but suggest that despite evidence of clinical remission the majority of patients continue therapy. <h3>Disclosure of Interest</h3> None Declared.
Critical Issues in US Health Care
Authors: Joshua Sharfstein, Phil B. Fontanarosa, Howard Bauchner
Journal: JAMA (2013)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
AUTOLOGOUS SKELETAL-MYOBLAST-SHEET TRANSPLANTATION IMPROVED PORCINE CARDIAC FUNCTION WITHOUT INCREASING RISK OF ARRHYTHMIA
Authors: Yutaka Terajima, Tatsuya Shimizu, Shinpei Tsuruyama, Hidekazu Sekine, Nobuhisa Hagiwara, Teruo Okano
Journal: Journal of the American College of Cardiology (2012)
Phonocardiographic Diagnosis of Ball Variance in Aortic Valve Prostheses.
Authors: J. C. Hylen
Journal: Annals of Internal Medicine (1968)

s1 May 1968Phonocardiographic Diagnosis of Ball Variance in Aortic Valve Prostheses.J. C. Hylen, M.D., P. Q. Hull, M.D., A. W. Ames, M.D., F. E. Kloster, M.D., R. H. Herr, M.D.J. C. Hylen, M.D.Search for more papers by this author, P. Q. Hull, M.D.Search for more papers by this author, A. W. Ames, M.D.Search for more papers by this author, F. E. Kloster, M.D.Search for more papers by this author, R. H. Herr, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-68-5-1156_2 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptPhysical and chemical alterations in the silastic poppets of Starr-Edwards aortic valve prostheses or ball variance have been observed in over 15% of 270 patients. Swelling, grooving, eccentricity, and fragmentation can lead to acute malfunction and death if not corrected. Clinical diagnosis of ball variance has rested heavily on finding a loss, decrease, or varying intensity of the aortic opening sound by auscultation and phonocardiography, as most patients are asymptomatic. The present study established diagnostic criteria for ball variance to allow accurate antemortem diagnosis and early reoperation. Phonocardiograms (PCG) were recorded on 15 patients with ball variance subsequently verified at... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: J. C. Hylen, M.D.; P. Q. Hull, M.D.; A. W. Ames, M.D.; F. E. Kloster, M.D.; R. H. Herr, M.D.Affiliations: Portland, Oregon PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 May 1968Volume 68, Issue 5Page: 1156-1156KeywordsAortic valveAuscultationInflammation ePublished: 1 December 2008 Issue Published: 1 May 1968 PDF downloadLoading ...
Human Brucellosis Caused by<i>Brucella canis</i>
Authors: Sarah S. Polt, William E. Dismukes, Andrew Flint, Joanna Schaefer
Journal: Annals of Internal Medicine (1982)

Human infection by Brucella canis is not often recognized due to a lack of serious consideration of the disease as a diagnostic possibility. Another factor is the limited availability of specific serologic tests needed in the absence of cross-reactivity between antibodies to B. canis and other Brucella pathogenic to humans. In addition, the organism may not be isolated from blood culture, particularly after antibiotic therapy. We report clinical and laboratory features of four patients with serologically diagnosed B. canis infection and point out the importance of specific serologic testing for B. canis when brucellosis is a diagnostic possibility.
Baby boomers go bust
Authors: Des Spence
Journal: BMJ (2012)

Spawned of large families, they have an inbuilt social support system. Defined by silly, long beards, love ins, 10 minute long rock tracks, rayon, wholemeal bread, vegetarians, social mobility, communes, radical left wing politics (reserved only for middle class members), and final salary pension schemes. These are the spoilt baby boomers. Born after the war till 1965 they are a large demographic bulge. They bought houses for a few shells and beads, which are now worth millions. Baby boomers hold 80% of the country’s wealth.1 They enjoyed professional freedom, …
Extensive human papillomavirus-related disease (bowenoid papulosis, Bowen's disease, and squamous cell carcinoma) in a patient with hairy cell leukemia: Clinical and immunologic evaluation after an interferon alfa trial
Authors: C. Lebbe, M. Rybojad, S. Ochonisky, J.M. Miclea, O. Verola, Florence Cordoliani, Glynis Ablon, P. Morel
Journal: Journal of the American Academy of Dermatology (1993)
Ian Donald: A Memoir
Authors: Geoffrey Chamberlain
Journal: Journal of the Royal Society of Medicine (2005)

Many books could be written about the great character Ian Donald of Glasgow. One could be an account of the origins of ultrasound, how Donald developed the science from undersea submarine detection to equipment which revolutionized firstly obstetrics and then other medical fields. Another book could be about his passion for caring for patients and the meticulous care he gave them through his life; Donald was selfish for all he believed in, and fought valiantly for it. Others could write of the strongly held Christian faith of the man and how it ruled his culture and attitudes to contraception and abortion and the battles this led him into. This short volume is a panegyric by two of his apostles which, like the centre of a Venn diagram, takes in all areas of Donald's life.

All who worked with Ian Donald were affected by him. The late James Willocks and Wallis Barr have faithfully followed the Donald story chronologically. Early formative years are considered only briefly. Donald's medical career is then laid out with natural emphasis on the Glasgow years and his part in the teaching and research side of that university. His work in the design and construction of the Queen Mother's Hospital is traced; that building remains his monument. About a quarter of the book is quite rightly devoted to ultrasound, Donald's great legacy. This account reads well, for the authors were there through the formative years. A larger and more detailed biography of this hero of Scottish medicine is needed, but until it comes the memoir is an excellent libra brevis.
Phase III two by two factorial comparison of doxorubicin and cyclophosphamide followed by a taxan <i>vs.</i> a taxan alone, and paclitaxel <i>vs.</i> docetaxel in operable node positive breast cancer – results of the first interim analysis of NSASBC02 trial.
Authors: T Watanabe, M Kuranami, K Inoue, N Masuda, K Aogi, S Oono, H Iwata, H Mukai, S Tanaka, T Yamaguchi, Y Ohashi
Journal: Cancer Research (2009)

Abstract Abstract #4103 Background: Evidence suggests that anthracycline-containing regimens can be excluded in some patients(pts) with operable breast cancer. It is also suggested that docetaxel (D) is more effective than paclitaxel (P) in metastatic breast cancer (BC) pts.&amp;#x2028; Methods: Eligibility included axillary lymph node positive BC age less than 70 years old. Pts were randomized to receive either AC(doxorubicin 60 mg/m2 and cyclophosphamide 600 mg/m2) every(q) 3 weeks(wks) x 4 followed by P 175 mg/m2 q3 wks x 4 (ACP), same AC followed by D 75 mg/m2 q3 wks x 4(ACD), P 175 mg/m2 q3 wks x 8 (PTX) or D 75 mg/m2 q3 wks x 8(DTX). Comparison included taxane (ACP+PTX vs. ACD+DTX) and with AC or without AC (ACP+ACD vs. PTX+DTX). The primary endpoint was disease free survival (DFS) and the secondary endpoints included overall survival, adverse events(AE) and quality of life (QOL). The trial was powered to prove the non-inferiority of regimens without AC to those with AC(threshold hazard ratio 1.321) in terms of DFS.&amp;#x2028; Results: A total of 1,060 eligible pts were accrued from 84 centers between Dec. 2000 and Mar.2006. 270 DFS events and 106 deaths after a median follow-up of 46.5 months were observed. The hazard ratio (HR) of DFS between ACD+DTX and ACP+PTX was 0.81(95% Confidence Interval (CI); 0.64-1.03) (p=0.08). The HR of DFS between PTX+DTX and ACP+ACD was 1.26 (95% CI; 0.99-1.60) ( p=0.67) in all eligible pts but was 1.85 (95% CI; 1.11-3.07)(p=0.017) in pts with HER2 overexpressing BC and 1.11(95% CI; 0.85-1.46)( p=0.44) in pts with HER2 non-overexpressing BC. AEs of grade 3 or 4 were observed in the lowest incidence in PTX arm and edema was observed in 11% of pts in DTX arm(p=0.01), neutropenic fever was more frequent in D cotaining arms(Table1). Conclusions: DFS was better in the arms containing D than in the arnms with P. AC improved DFS in the subset of pts with HER2 overexpressing BC but not in non-selected population. Higher incidence of severe AEs was observed in the arms containing D than in arms with P.&amp;#x2028; &amp;#x2028; Citation Information: Cancer Res 2009;69(2 Suppl):Abstract nr 4103.