The Rôle of Bacteria in Allergy, with Special Reference to Asthma
Authors: R. L. Benson
Journal: Annals of Internal Medicine (1933)

Article1 March 1933The Rôle of Bacteria in Allergy, with Special Reference to AsthmaR. L. BENSON, A.M., M.D., F.A.C.P.R. L. BENSON, A.M., M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-6-9-1136 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptAs early as the beginning of the present century the late Victor C. Vaughan1already had an adequate understanding of the problems of bacterial sensitization. This eminent biochemist maintained that bacteria, although morphologically simple in structure, are correspondingly complicated in their chemistry and comprise in particular a group of highly complex proteins. His insight into the minute chemistry of bacteria is further evidenced by his account of one or more carbohydrate components which he regarded as intimately linked with the large nucleoprotein molecules. He concluded that these constituents could readily be split apart by dilute acid or alkali, but better...References1 VAUGHAN VC: The bacterial toxins, Trans. Assoc. Am. Phys., 1901, xvi, 217; A study of bacterial cells, ibid., 1902, xvii, 243; Protein split products, 1913, Lea and Febiger, Philadelphia, p. 17. Google Scholar2 DIBLE JH: Recent advances in bacteriology, 1932, P. Blakiston's Son and Co., Philadelphia. Google Scholar3 DOCHEZAVERY AROT: Elaboration of specific soluble substance, Jr. Exper. Med., 1917, xxvi, 477. CrossrefGoogle Scholar4 ZINSSERPARKER HJT: Bacterial hypersusceptibility, Jr. Exper. Med., 1923, xxxvii, 275-302. CrossrefGoogle Scholar5 TOENNIESSEN E: I. Untersuchungen über die Kapsel (Kummihülle) der pathogenen Bakterien. II. Die chemische Beschaffenheit der Kapsel und ihr dadurch bedingtes Verhalten gegenüber der Fixierung und Färbung, Centralbl. f. Bakteriol., Abt. 1, Orig., 1921, lxxxv, 225-237, cit. by DIBLE, loc. cit. Google Scholar6 MUELLERTOMCSIK JHJ: Chemical nature of residue antigen prepared from yeast, Jr. Exper. Med., 1924, xl, 343-352. CrossrefGoogle Scholar7 LANCEFIELD RC: Immunological relationship of Streptococcus viridans and certain of its chemical fractions, serological reactions obtained with antibacterial sera, Jr. Exper. Med., 1925, xlii, 377-395. CrossrefGoogle Scholar8 HITCHCOCK CH: Classification of hemolytic streptococci by precipitin reaction, Jr. Exper. Med., 1924, xl, 445-452. CrossrefGoogle Scholar9 PRZESMYCKI F: Specific "residue antigens" of different types of meningococci, Jr. Infect. Dis., 1924, xxxv, 537-539. CrossrefGoogle Scholar10 PICK : cited by ZINSSER and PARKER, loc. cit. Google Scholar11 SABIN AB: On presence in antipneumococcus serum of type-specific protective antibody not neutralized by homologous specific soluble substance, Jr. Exper. Med., 1931, liii, 93-107. CrossrefGoogle Scholar12 ENDERS JF: Type specific substance distinct from specific carbohydrate in pneumococcus Type I, Jr. Exper. Med., 1930, lii, 235-252. CrossrefGoogle Scholar13 MILLER JL: Typhoid, Ill. Med. Jr., 1916, xxix, 8. Foreign proteins, Jr. Am. Med. Assoc., 1916, lxvi, 1756. The effect of foreign protein therapy in lobar pneumonia, Jr. Am. Med. Assoc., 1920, lxxiv, 1598. Google Scholar14 COCAWALZERTHOMMEN AFMAA: Asthma and hay fever, 1931, Charles C. Thomas, Springfield, Ill. Google Scholar15 TOPLEYWILSON WWGS: Principles of bacteriology and immunity, 1929, ii, Wood and Co., New York. Google Scholar16 PILOT I: Skin reactions with Staphylococcus aureus , Jr. Allergy, 1931, iii, 86. Google Scholar17 POTTENGER FM: Similarities and differences in bacterial and non-bacterial allergy, Jr. Allergy, 1920, i, 235-244. Google Scholar18 STORM VAN LEEUWENMAYTUM AJCK: Bacteriologic study on the etiology of bronchial asthma, Proc. Staff Meetings, Mayo Clinic, 1931, vi, 259. (Cited in Jr. Allergy, 1931, ii, 516). Google Scholar19 FRIEDBERGER : cited by VAUGHAN, Protein split products, 1913, Lea and Febiger, Philadelphia and New York. Google Scholar20 HARKAVY J: Spasm-producing substance in sputum of patients with bronchial asthma, Arch. Int. Med., 1930, xlv, 641-646. CrossrefGoogle Scholar21 KOESSLERHANKESHEPPARD KKMTMS: Production of histamine, tyramine, bronchospastic and arteriospastic substances in blood broth by pure cultures of microörganisms, Jr. Infect. Dis., 1928, xliii, 363-377. CrossrefGoogle Scholar22 ARTHUS M: Injections répétées de sérum de cheval chez le lapin, Compt, rend. de la Soc. biol., Par., 1903, lv, 817-820, (Cited by VAUGHAN, loc. cit.) Google Scholar23 SHWARTZMAN G: Phenomenon of local skin reactivity to bacterial filtrates; passive immunity to reacting factors, Jr. Exper. Med. 1931, liv, 1-10; (also see COCA, loc. cit., p. 87). CrossrefGoogle Scholar24 DICKDICK GFGH: Experimental scarlet fever, Jr. Am. Med. Assoc., 1923, lxxxi, 1166-1167; Skin test for susceptibility to scarlet fever, Jr. Am. Med. Assoc., 1924, lxxxii, 265-266; Etiology of scarlet fever, Jr. Am. Med. Assoc., 1924, lxxxii, 301-302; Scarlet fever toxin in preventive immunization, Jr. Am. Med. Assoc., 1924, lxxxii, 544-545; Method of recognizing scarlet fever streptococci by means of specific toxin production, Jr. Am. Med. Assoc., 1925, lxxxiv, 802-803. CrossrefGoogle Scholar25 TOUART MD: Autogenous vaccine skin tests, Jr. Allergy, 1929, i, 85-86. Google Scholar26 ZINSSER H: Significance of bacterial allergy in infectious diseases, Bull. N.Y. Acad. Med., 2nd series, 1928, iv, 351-383. Google Scholar27 ZINSSERTAMIYA HT: Studies on antigenic substance of bacterial cell, Jr. Exper. Med., 1925, xlii, 311-321. CrossrefGoogle Scholar28 BENSON RL: A hopeful view of asthma, Northwest Med., 1932, xxxi, 153-160. Google Scholar29 THOMAS WS: Asthma, its diagnosis and treatment, Paul B. Hoeber, Inc., New York. Google Scholar30 HAIBE A: L'asthme bronchique et son traitement, Ann. Soc. scient. de Bruxelles, 1930, l, 16-64; also Rev. belge. sc. med., 1931, iii, 564-612. Google Scholar31 WRIGHT AE: Studies on immunization, 1909, Constable and Co., London. Google Scholar32 WALKER IC: Treatment of bronchial asthma, Arch. Int. Med., 1919, xxiii, 220; and others. CrossrefGoogle Scholar33 AVERYHEIDELBERGER OTM: Immunological relationships of cell constituents of pneumococcus, Jr. Exper. Med., 1925, xlii, 367-376. CrossrefGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Portland, Oregon*Read before the Sixteenth Annual Clinical Session of the American College of Physicians, San Francisco, April 5, 1932. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byBACTERIAL VACCINES IN THE TREATMENT OF BRONCHIAL ASTHMAAsthma bronchialeBakterien als Ursache allergischer Asthmaanfälle (Versuche mit Keimen aus der Klebsiella-Gruppe)LXXVII A Bronchologist's Experiences with Infectious AsthmaTreatment of hyperplastic sinusitisLXXXII The Allergic Factor in Chronic Bronchopulmonary InfectionsStudies in bacterial allergyStudies in bacterial allergyAllergic relations of normal and abnormal floras of the intestine 1 March 1933Volume 6, Issue 9Page: 1136-1152KeywordsAllergy and immunologyAsthmaBacteriaCarbohydratesProtein structure ePublished: 1 December 2008 Issue Published: 1 March 1933 PDF downloadLoading ...