tbuckley/cabot-search huggingface dataset:
ASIAN INFLUENZA IN THE UNITED STATES
Authors: A D LANGMUIR
Journal: Annals of Internal Medicine (1958)

Article1 September 1958ASIAN INFLUENZA IN THE UNITED STATESALEXANDER D. LANGMUIR, M.D.ALEXANDER D. LANGMUIR, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-49-3-483 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe worldwide pandemic of Asian strain influenza during 1957 was the most dramatic epidemiologic phenomenon since the pandemics of influenza in 1918 and in 1889-1890. The accuracy of the predictions, the duration of the advanced warnings and the scope of the effort to control it in this country are unique in the history of organized medicine and public health.In this presentation, I would like (1) to discuss briefly the remarkable character of the predictions that were made; (2) to describe the course of the epidemic in this country, including the wave of mortality in the winter and spring of... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Atlanta, Georgia*From the Symposium on Influenza, presented at the Thirty-ninth Annual Session of The American College of Physicians, Atlantic City, New Jersey, April 28, 1958.From the Communicable Disease Center, Public Health Service, U. S. Department of Health, Education, and Welfare, Atlanta, Georgia.Requests for reprints should be addressed to Alexander D. Langmuir, M.D., Chief, Epidemiology Branch, Communicable Disease Center, Bureau of States Services, 50 Seventh Street, Northeast, Atlanta 23, Georgia. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byInfluenza PandemicsPublic Health and Medical Responses to the 1957-58 Influenza PandemicMyxovirenDeaths from Asian influenza associated with pregnancyAsian Influenza — Retrospect and Prospect 1 September 1958Volume 49, Issue 3Page: 483-492KeywordsAntigensEpidemiologyHistory of medicineMedical servicesMortalityPrevention, policy, and public health ePublished: 1 December 2008 Issue Published: 1 September 1958 Copyright & PermissionsCopyright ©, 1958, by The American College of PhysiciansPDF downloadLoading ...
Abstract 17022: Non-High Density Lipoprotein Cholesterol in Incident and Progression of Coronary Artery Calcium
Authors: Vikas Veeranna, Sandip Zalawadiya, Ashutosh Niraj, Krithi Ramesh, Sidakpal Panaich, Naga Kommuri, Luis Afonso
Journal: Circulation (2011)

Background Non-High density lipoprotein cholesterol (non-HDLc) is an independent predictor of cardiovascular (CVD) risk, with elevated levels signifying an increased risk beyond low density lipoprotein (LDL) . We sought to evaluate the association between non-HDL c and development (incident) and progression of coronary artery calcium (CAC) in multi-ethnic asymptomatic individuals. Methods The study cohort was derived from the limited access dataset of the Multi Ethnic Study of Atherosclerosis obtained from the National Heart Lung and Blood Institute. The cohorts for incident CAC as well as CAC progression included 2778 subjects with a median follow-up of 2.4 ± 0.8 years. Multivariable regression analysis was performed to derive the association between non-HDL c and incident CAC and non-HDLc and progression of CAC. Results In population without CAC at baseline, non-HDL c, especially &gt; 200mg/dl, was an independent predictor of incident CAC in the overall population and in both the genders beyond the traditional risk factors including for age, sex, race, systolic blood pressure, anti-hypertension medications use, smoking status, diabetes, lipid lowering therapy use, follow-up duration and waist-hip ratio. (Table 1) Similarly, in those with CAC at baseline, non-HDLc levels &gt;200mg/dl was associated with significant CAC progression in overall population and in both the genders upon similar adjustments.(Table 2) Conclusion Non-HDLc, especially &gt;200mg/dl, is associated with increased risk of incident CAC as well as progression of CAC in a multi-ethnic cohort of individuals without any CVD. Non-HDLc provides a second measure of atherogenic risk ad progression beyond LDL.
Knowledge That the Myelodysplastic Syndromes (MDS) Are a Type of Cancer Does Not Influence Patient Perception of Treatment Discontinuation
Authors: Aaron T. Gerds, Betsy Dennison, Joan Latsko, Alice Houk, Stephanie Chisolm, John M. Huber, Richard M. Stone, Jaroslaw P. Maciejewski, Rami S Komrokji, Guillermo Garcia-Manero, David P. Steensma, Mikkael A. Sekeres
Journal: Blood (2014)
Mitochondrial Dysfunction as an Arrhythmogenic Substrate
Authors: David Montaigne, Xavier Marechal, Philippe Lefebvre, Thomas Modine, Georges Fayad, Helene Dehondt, Christopher Hurt, Augustin Coisne, Mohamed Koussa, Isabelle Remy-Jouet, Farid Zerimech, Eric Boulanger, Dominique Lacroix, Bart Staels, Remi Neviere
Journal: Journal of the American College of Cardiology (2013)
Influenza Activity— United States and Worldwide, April-October 2000
Authors: A. Hay, A. Hampson, M. Tashiro, S. Lea, C. Burgoon, M. Gaglani, G. Herschler, D. Haught, L. Dobin, D. Berkman, N. Pascoe, J. Morgan, M. A. Patterson, D. Romnes, D. Bergmire-Sweat
Journal: JAMA (2000)
History, Alternative Medicine
Authors: Freddie Ann Hoffman
Journal: JAMA (2005)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Fast-Growing Gastric Inflammatory Pseudotumor: A Rare Manifestation of Peptic Ulcer Disease
Authors: O. Al-Taie, H. Mörk, M. Jenett, D. Klein, J. Müller, M. Scheurlen
Journal: Endoscopy (2002)

Inflammatory pseudotumors (synonymous with inflammatory fibrous polyps) are benign lesions which must be differentiated from other stroma tumors such as leiomyomas or sarcomas. In the stomach, inflammatory pseudotumors are rare.
Somatostatin-Like Immunoreactivity in Rat Blood
Authors: M. Berelowitz, S. Kronheim, B. Pimstone, B. Shapiro
Journal: Journal of Clinical Investigation (1978)

Somatostatin-like immunoreactivity (SLI) has been demonstrated by radioimmunoassay (RIA) in rat serum using an antiserum specific for somatostatin and cross-reacting maximally with the biologically important area on the peptide. The RIA has a sensitivity of 35 pg/ml. SLI dilutes in parallel with synthetic somatostatin standard in the RIA and shows characteristics similar to synthetic somatostatin on Sephadex G-25 (f) gel chromatography eluting largely as a single peak with 1 M acetic acid. Significant regional differences in serum SLI are present. A positive gradient was found in paired samples from aorta (mean+/-SEM, 0.304+/-0.024 ng/ml) and portal vein (0.495+/-0.047 ng/ml) consistent with the known presence of somatostatin in gut and pancreas, and a negative gradient was noted between paired samples from portal vein (0.523+/-0.076 ng/ml) and hepatic vein (0.290+/-0.048 ng/ml) indicating hepatic clearance. No significant differences were demonstrated between aorta and confluence of cerebral venous sinuses or between aorta and inferior vena cava (IVC). After intragastric glucose, a significant and marked elevation of portal SLI was observed, maximal at 5 min (0.416+/-0.137 vs. 1.55+/-0.30 ng/ml at 5 min). A significant biphasic elevation of portal SLI also occurred after intravenous glucose. After both routes of glucose administration, the patterns of portal SLI followed closely those of portal glucose and insulin. By contrast, IVC SLI failed to reflect these changes.Thus, SLI in the rat shows chromatographic similarity with synthetic somatostatin. Regional differences in serum levels are marked; the highest concentrations being found in the portal venous effluent of pancreas and gut. Furthermore, glucose causes elevation of portal SLI in a pattern similar to portal insulin and glucose and without concomitant elevation in IVC. This differential elevation of SLI after glucose is consistent with a hormonal action within the portal system as a direct effect of somatostatin on the liver has previously been demonstrated. In addition, the liver is important in the clearance of portal SLI, possibly to prevent extraportal effects in response to gut and pancreatic stimulation. Finally, it is clear that regional sampling of serum for SLI measurement may be critical in the investigation of the putative physiological roles for somatostatin.
Longitudinal assessment of symptoms of depression, agitation, and psychosis in 181 patients with Alzheimer's disease
Authors: M L Levy, J L Cummings, L A Fairbanks, D Bravi, M Calvani, A Carta
Journal: American Journal of Psychiatry (1996)

The goal of this study was to define the recurrence or continuation of neuropsychiatric symptoms in patients with Alzheimer's disease who were observed serially for a 1-year period.One hundred eighty-one patients with probable Alzheimer's disease were assessed five times at 3-month intervals with a standardized neuropsychiatric rating instrument.Recurrence rates of neuropsychiatric symptoms during the 1-year period were 85% for depression, 93% for agitation, and 95% for psychosis. Symptom frequency at any point in time underestimated the cumulative 1-year frequency. Recurrence rates were significantly greater among patients who had multiple symptoms. Women exhibited more symptoms than men. Patients in the oldest age group (76-87 years) had more psychosis, less depression and agitation, and slower cognitive decline. Psychosis was associated with more rapid cognitive decline, and agitation was associated with more rapid functional deterioration.These results indicate that once psychiatric symptoms are present in patients with Alzheimer's disease, they frequently recur. These symptoms vary with age, sex, and rate of illness progression.
Abstract 13072: Bone Marrow Reconstitution Restores Cardiac-Resident Stem Cells and Enhances Cardiac Repair after Infarction
Authors: Shu-Hong Li, Zhuo Sun, Keith R Brunt, Richard D Weisel, Ren-Ke Li
Journal: Circulation (2011)

Introduction: The adult heart retains a small population of progenitor cells that are essential for cardiac regeneration after injury. In aged individuals, these cells are diminished and dysfunctional, which may contribute to progressive heart failure. The derivation of these cardiac progenitors is debated, and methods to restore their number and function are required. We assessed the hypothesis that bone marrow (BM) rejuvenation can restore cardiac progenitor cells, which augment myocardial repair after injury. Methods: Old female mice (22 months) were lethally irradiated and infused with 5×106 fresh BM cells from either young (2 months) or old male GFP mice to produce two groups of chimeras (n=60/group). Following an 8-week recovery, chimeric mice were again subjected to lethal irradiation followed by infusion of BM cells, but this time from old female donors. Some mice received whole-body irradiation (n=25); however, in some mice, the heart was protected from irradiation with a carefully positioned lea...
Abstract 2558: The mechanistic study on the effect of platinum-based chemotherapy efficacy imposed by EGFR-TKI regulated ERCC1 in non-small cell lung cancer (NSCLC)
Authors: Hio Teng Cheong, Connie Wun Chun Hui, Fei Xu, Tony Shu Kam Mok, Chi Hang Wong
Journal: Cancer Research (2015)

Abstract Platinum-based chemotherapy is conventionally the first line treatment for EGFR wild type patients while EGFR-TKI is the standard for patients with mutation. Subgroup biomarker studies conducted in FASTACT-2 (Wu et al Lancet Oncology 2013) indicated that patients with positive ERCC1 attained longer overall survival and progression free survival under intercalated chemotherapy and EGFR-TKI, in comparison with solely chemotherapy. EGFR-TKI is postulated to down-regulate ERCC1 expression in EGFR wild type NSCLC cells, hence enhancing the Chemo efficacy. The study aims to investigate the missing link between EGFR and ERCC1 in the perspective of mechanistic means. In vitro and in vivo studies were devised to examine the impact imposed on ERCC1 by EGFR-TKI. H1993 cells underwent a 72-hour EGFR-TKI treatment and transient siRNA transfection for ERCC1 suppression. Cell viability assay was employed for detecting the cisplatin sensitivity of the transfected cells. Xenograft tumor models were established with a 2-week treatment of oral erlotinib on animals, using western blot and IHC to study the ERCC1 expression. Human EGFR Phosphorylation Membrane Array was used to study the EGFR phosphorylation pattern involved in ERCC1 level alterations and its downstream pathways were further analyzed with western blot. ERCC1 expression level is not correlated with EGFR-TKI sensitivity. Nonetheless, ERCC1 level gradually decreased along the 72-hour exposure of EGFR-TKI. The cells’ sensitivity towards cisplatin was raised upon ERCC1 knock-down with its IC50 reduced from 14.67μM to 0.16μM. Furthermore, TKI showed a significant reduction in ERCC1 level with IHC staining after treatment yet no sequel on the tumor volume of the xenografts. On the mechanistic side, 6 out of 17 EGFR phosphorylation sites were found compelling in respond to variations on ERCC1 level. We discovered that the MAPK/ERK and JNK pathways were the potential candidates that regulated EGFR associated ERCC1 expression. In summary, the data manifested that EGFR-TKI may reduce ERCC1 expression and latently enhance sensitivity towards cisplatin. MAPK/ERK and JNK pathways may contribute in ERCC1 regulation. With the preliminary screening results, it warrants further investigation to validate the underlying mechanism for the regulation of ERCC1 expression level. Citation Format: Hio Teng Cheong, Connie Wun Chun Hui, Fei Xu, Tony Shu Kam Mok, Chi Hang Wong. The mechanistic study on the effect of platinum-based chemotherapy efficacy imposed by EGFR-TKI regulated ERCC1 in non-small cell lung cancer (NSCLC). [abstract]. In: Proceedings of the 106th Annual Meeting of the American Association for Cancer Research; 2015 Apr 18-22; Philadelphia, PA. Philadelphia (PA): AACR; Cancer Res 2015;75(15 Suppl):Abstract nr 2558. doi:10.1158/1538-7445.AM2015-2558
Alzheimer's disease and its Lewy body variant: a clinical analysis of postmortem verified cases
Authors: M F Weiner, R C Risser, C M Cullum, L Honig, C White, S Speciale, R N Rosenberg
Journal: American Journal of Psychiatry (1996)

The authors compared clinical findings of Alzheimer's disease and the so-called Lewy body variant of Alzheimer's disease.Available data were analyzed on the clinical features of 58 patients with Alzheimer's disease and 24 patients with the Lewy body variant of Alzheimer's disease who underwent postmortem examination.The proportion of men was significantly larger in the Lewy body variant group than in the Alzheimer's disease group (66.7% versus 34.5%), and, concordantly, the Lewy body variant group was slightly taller. The prevalence of hallucinations and delusions was significantly higher in Lewy body variant subjects than the Alzheimer's disease subjects, but there were no significant differences between the two groups in educational attainment, family history of dementia, age at onset, duration of illness, cognitive impairment, overall severity of illness, or neuropsychological findings. Patients with the Lewy body variant of Alzheimer's disease tended to experience more frequent extrapyramidal side effects of neuroleptics than did the patients with Alzheimer's disease, but for patients in the two groups who were not exposed to neuroleptics, there was little difference in frequency of extrapyramidal side effects. CSF concentration of homovanillic acid (HVA) was significantly lower in the Lewy body variant patients, even when correction was made for height.The Lewy body variant of Alzheimer's disease may be suspected in elderly male dementia patients who otherwise meet criteria for Alzheimer's disease but who manifest significant psychiatric symptoms and neuroleptic-induced extrapy-ramidal side effects and have low levels of CSF HVA.
Anaesthesia and Analgesia in Labour
Authors: R Mitchell
Journal: JAMA (1935)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Occupation and Risk of Non-Hodgkin Lymphoma and Its Subtypes: A Pooled Analysis from the InterLymph Consortium
Authors: Andrea ‘t Mannetje, Anneclaire J. De Roos, Paolo Boffetta, Roel Vermeulen, Geza Benke, Lin Fritschi, Paul Brennan, Lenka Foretova, Marc Maynadié, Nikolaus Becker, Alexandra Nieters, Anthony Staines, Marcello Campagna, Brian Chiu, Jacqueline Clavel, Silvia de Sanjose, Patricia Hartge, Elizabeth A. Holly, Paige Bracci, Martha S. Linet, Alain Monnereau, Laurent Orsi, Mark P. Purdue, Nathaniel Rothman, Qing Lan, Eleanor Kane, Adele Seniori Costantini, Lucia Miligi, John J. Spinelli, Tongzhang Zheng, Pierluigi Cocco, Anne Kricker
Journal: Environmental Health Perspectives (2015)

Various occupations have been associated with an elevated risk of non-Hodgkin lymphoma (NHL), but results have been inconsistent across studies. We investigated occupational risk of NHL and of four common NHL subtypes with particular focus on occupations of a priori interest. We conducted a pooled analysis of 10,046 cases and 12,025 controls from 10 NHL studies participating in the InterLymph Consortium. We harmonized the occupational coding using the 1968 International Standard Classification of Occupations (ISCO-1968) and grouped occupations previously associated with NHL into 25 a priori groups. Odds ratios (ORs) adjusted for center, age, and sex were determined for NHL overall and for the following four subtypes: diffuse large B-cell lymphoma (DLBCL), follicular lymphoma (FL), chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL), and peripheral T-cell lymphoma (PTCL). We confirmed previously reported positive associations between NHL and farming occupations [field crop/vegetable farm workers OR = 1.26; 95% confidence interval (CI): 1.05, 1.51; general farm workers OR = 1.19; 95% CI: 1.03, 1.37]; we also confirmed associations of NHL with specific occupations such as women's hairdressers (OR = 1.34; 95% CI: 1.02, 1.74), charworkers/cleaners (OR = 1.17; 95% CI: 1.01, 1.36), spray-painters (OR = 2.07; 95% CI: 1.30, 3.29), electrical wiremen (OR = 1.24; 95% CI: 1.00, 1.54), and carpenters (OR = 1.42; 95% CI: 1.04, 1.93). We observed subtype-specific associations for DLBCL and CLL/SLL in women's hairdressers and for DLBCL and PTCL in textile workers. Our pooled analysis of 10 international studies adds to evidence suggesting that farming, hairdressing, and textile industry-related exposures may contribute to NHL risk. Associations with women's hairdresser and textile occupations may be specific for certain NHL subtypes. 't Mannetje A, De Roos AJ, Boffetta P, Vermeulen R, Benke G, Fritschi L, Brennan P, Foretova L, Maynadié M, Becker N, Nieters A, Staines A, Campagna M, Chiu B, Clavel J, de Sanjose S, Hartge P, Holly EA, Bracci P, Linet MS, Monnereau A, Orsi L, Purdue MP, Rothman N, Lan Q, Kane E, Seniori Costantini A, Miligi L, Spinelli JJ, Zheng T, Cocco P, Kricker A. 2016. Occupation and risk of non-Hodgkin lymphoma and its subtypes: a pooled analysis from the InterLymph Consortium. Environ Health Perspect 124:396-405; http://dx.doi.org/10.1289/ehp.1409294.
Abstract 3770: Stroke Risk Score in Patients with Acute Coronary Syndromes. The Global Registry of Acute Coronary Events
Authors: Andrzej Budaj, Katarzyna Flasinska, Enrique P Gurfinkel, Joel M Gore, Jose Lopez-Sendon, David Brieger, Brian M Kennelly, Gordon FitzGerald, Keith A Fox
Journal: Circulation (2007)
Sex-Related Differences of Coronary Atherosclerosis Regression Following Maximally Intensive Statin Therapy
Authors: Rishi Puri, Steven E Nissen, Mingyuan Shao, Christie M Ballantyne, Phillip J Barter, M John Chapman, Raimund Erbel, Peter Libby, Joel S Raichlen, Kiyoko Uno, Yu Kataoka, Stephen J Nicholls
Journal: JACC. Cardiovascular imaging (2014)