Q FEVER—A REVIEW OF CURRENT KNOWLEDGE
Authors: R J HUEBNER, W L JELLISON, M D BECK
Journal: Annals of Internal Medicine (1949)

Article1 March 1949Q FEVER—A REVIEW OF CURRENT KNOWLEDGEROBERT J. HUEBNER, M.D., WILLIAM L. JELLISON, Ph.D., M. DORTHY BECK, M.A.ROBERT J. HUEBNER, M.D.Search for more papers by this author, WILLIAM L. JELLISON, Ph.D.Search for more papers by this author, M. DORTHY BECK, M.A.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-30-3-495 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptQ fever is an acute specific, often serious, and occasionally fatal rickettsial disease of man. It is characterized by a high fever, headache and malaise and is often misdiagnosed as influenza or atypical pneumonia. It is also a disease of animals and it is the animal reservoir of the disease which is thought to be the immediate source of most human infection. Although the causative agent of Q fever,Coxiella burneti(=Rickettsia burneti) has been known and studied since 1937, Q fever, until recently, was looked upon as little more than a medical curiosity of importance to certain communities...Bibliography1. TOPPINGSHEPARDIRONS NHCCJV(a) : Q fever in the United States. I. Epidemiologic studies of an outbreak among stock handlers and slaughterhouse workers, Jr. Am. Med. Assoc., 1947, cxxxiii, 813-815. (b) IRONS, J. V., and HOOPER, J. M.: Q fever in the United States. II. Clinical data on an outbreak among stock handlers and slaughterhouse workers, Jr. Am. Med. Assoc., 1947, cxxxiii, 815-818. (c) IRONS, J. V., MURPHY, J. N., JR., and WOLFE, D. M.: Q fever in the United States. III. Serologic observations in an outbreak among stock handlers and slaughterhouse workers, Jr. Am. Med. Assoc., 1947, cxxxiii, 819-820. (d) COX, H. R., TESAR, W. C., and IRONS, J. V.: Q fever in the United States. IV. Isolation and identification of rickettsias in an outbreak among stock handlers and slaughterhouse workers, Jr. Am. Med. Assoc., 1947, cxxxiii, 820-821. CrossrefGoogle Scholar2. SHEPARD CC: An outbreak of Q fever in a Chicago packing house, Am. Jr. Hyg., 1947, xlvi, 185-192. Google Scholar3. EKLUNDPARKERLACKMAN CMRRDB: A case of Q fever probably contracted by exposure to ticks in nature, Pub. Health Rep., 1947, lxii, 1413-1416. CrossrefGoogle Scholar4. SUSSMAN O: Unpublished data. Google Scholar5. YOUNG FW: Q fever in Artesia, Los Angeles County Health Index, May 17, 1948. Google Scholar6. SHEPARDHUEBNER CCRJ: Q fever in Los Angeles County. Description of some of its epidemiological features, Am. Jr. Pub. Health, June, 1948. CrossrefGoogle Scholar7. HUEBNERJELLISONBECKPARKERSHEPARD RJWLMDRRCC: Q fever studies in southern California. I. Recovery of Rickettsia burneti from raw milk, Pub. Health Rep., 1948, lxiii, 214-222. CrossrefGoogle Scholar8. BECKBELLHUEBNER MDJARJ: Unpublished data. Google Scholar9. HUEBNERJELLISONBECK RJWLMD: Unpublished data. Google Scholar10. DERRICK EH: "Q" fever, a new fever entity: Clinical features, diagnosis and laboratory investigations, Med. Jr. Australia, 1937, 281-299. CrossrefGoogle Scholar11. DERRICK EH: Rickettsia burneti—the cause of "Q" fever, Med. Jr. Australia, 1939, 14. CrossrefGoogle Scholar12. BURNETFREEMAN FMM: Experimental studies on the virus of "Q" fever, Med. Jr. Australia, 1937, 299-305. CrossrefGoogle Scholar13. DERRICKSMITHBROWN EHDJHE: Studies in the epidemiology of Q fever. 9. The rôle of the cow in the transmission of human infection, Australian Jr. Exper. Biol. and Med. Sci., 1942, xx, 105-110. CrossrefGoogle Scholar14. SMITHDERRICK DJEH(a) : Studies in the epidemiology of Q fever. 1. The isolation of six strains of Rickettsia burneti from the tick Haemaphysalis humerosa , Australian Jr. Exper. Biol. and Med. Sci., 1940, xviii, 1-8. (b) DERRICK, E. H., SMITH, D. J. W., BROWN, H. E., and FREEMAN, MAVIS: The rôle of the bandicoot in the epidemiology of "Q" fever: A preliminary study, Med. Jr. Australia, 1939, 150-155. Google Scholar15. DAVISCOX GEHR: A filter-passing infectious agent isolated from ticks. I. Isolation from Dermacentor andersoni, reactions in animals, and filtration experiments, Pub. Health Rep., 1938, liii, 2259-2267. CrossrefGoogle Scholar16. COX HR: Studies of a filter-passing infectious agent isolated from ticks. V. Further attempts to cultivate in cell-free media. Suggested classification, Pub. Health Rep., 1939, liv, 1822-1827. CrossrefGoogle Scholar17. DYER RE: A filter-passing infectious agent isolated from ticks. IV. Human infection, Pub. Health Rep., 1938, liii, 2277-2282. Google Scholar18. DYER RE: Similarity of Australian "Q" fever and a disease caused by an infectious agent isolated from ticks in Montana, Pub. Health Rep., 1939, liv, 1229-1237. CrossrefGoogle Scholar19. HORNIBROOKNELSON JWKR: An institutional outbreak of pneumonitis. I. Epidemiological and clinical studies, Pub. Health Rep., 1940, lv, 1936-1944. CrossrefGoogle Scholar20. DYERTOPPINGBENGTSON RENHIA: An institutional outbreak of pneumonitis. II. Isolation and identification of causative agent, Pub. Health Rep., 1940, lv, 1945-1954. Google Scholar21. HESDORFFERDUFFALO MBJA: American Q fever; report of a probable case, Jr. Am. Med. Assoc., 1941, cxvi, 1901-1902. CrossrefGoogle Scholar22. STRAUSSSULKIN ESE: Studies on Q fever: Complement-fixing antibodies in meat packers at Fort Worth, Texas, Proc. Soc. Exper. Biol. and Med., 1948, lxvii, 139-141. CrossrefGoogle Scholar23. ROBBINSGAULDWARNER FCRLFB: Q fever in the Mediterranean area; report of its occurrence in Allied troops. II. Epidemiology, Am. Jr. Hyg., 1946, xliv, 23-50. Google Scholar24. ZARAFONETIS CJ: Virus of "Balkan grippe." Memorandum to the Director, U. S. of America Typhus Commission, dated Feb. 15, 1945. Google Scholar25. CAMINOPETROS J: Q fever (Balkan Grippe). Abstracts of Fourth International Congress on Tropical Medicine and Malaria, Washington, D. C., May 10-18, 1948, pp. 33-34. Google Scholar26. DENNIG H: Q-Fieber (Balkan Grippe), Deutsch. med. Wchnschr., 1947, lxxii, 369-370. CrossrefGoogle Scholar27. IMHAUSER K: Über das Auftreten von Branchopneumonien im Sudostraum, Ztschr. f. klin. Med., 1943, cxlii, 486-495. Google Scholar28. COMBIESCOVASILIUDUMITRESCU DVN: Identification d'une nouvelle rickettsiose chez l'homme en Roumanie, Compt. rend. Soc. d. biol., 1947, cxli, 716-717. Google Scholar29. GSELL O: Rickettsia burneti pneumonias, the "Q" fever of Switzerland, Med. and Hyg., 1947, v, 317. Google Scholar30. CHENEYGEIB GWA: The identification of Q fever in Panama, Am. Jr. Hyg., 1946, xliv, 158-172. Google Scholar31. RODANICHE : Personal communication. Google Scholar32. HUEBNER RJ: Unpublished data. Google Scholar33. PARKER RR: Unpublished data. Google Scholar34. PARKERSTEINHAUS RREA: American and Australian Q fevers: Persistence of the infectious agents in guinea pig tissues after defervescence, Pub. Health Rep., 1943, lviii, 523-527. CrossrefGoogle Scholar35. BURNETFREEMANDERRICKSMITH FMMEHDJ: The search for immunological relationship between "Q" fever and other rickettsioses, Med. Jr. Australia, 1939, 51-54. CrossrefGoogle Scholar36. PHILIP CB: Comments on the name of the Q fever organism, Pub. Health Rep., 1948, lxiii, 58. CrossrefGoogle Scholar37. BURNETFREEMAN FMM: A comparative study of rickettsial strains from an infection of ticks in Montana (United States of America) and from "Q" fever, Med. Jr. Australia, 1939, 887-891. CrossrefGoogle Scholar38. BENGTSON IA: Immunological relationships between the rickettsiae of Australian and American "Q" fever, Pub. Health Rep., 1941, lvi, 272-281. CrossrefGoogle Scholar39. ROBBINSRUSTIGIANSNYDERSMADEL FCRMJJE: Q fever in the Mediterranean area; report of its occurrence in Allied troops. III. The etiological agent, Am. Jr. Hyg., 1946, xliv, 51-63. Google Scholar40. Commission on Acute Respiratory Diseases. Identification and characteristics of the Balkan grippe strain of Rickettsia burneti , Am. Jr. Hyg., 1946, xliv, 110-122. Google Scholar41. TOPPINGSHEPARDHUEBNER NHCCRJ: Q fever. Immunologic comparison of strains, Am. Jr. Hyg., 1946, xliv, 173-182. Google Scholar42. DERRICKBURNET EHFM: Q fever, Proc. Sixth Pac. Sci. Congress, 1939, v, 745-752. Google Scholar43. ROBBINSRAGAN FCCA: Q fever in the Mediterranean area; report of its occurrence in Allied troops. I. Clinical features of the disease, Am. Jr. Hyg., 1946, xliv, 6-22. Google Scholar44. FEINSTEINYESNERMARKS MRJL: Epidemics of Q fever among troops returning from Italy in the spring of 1945. I. Clinical aspects of the epidemics at Camp Patrick Henry, Virginia, Am. Jr. Hyg., 1946, xliv, 72-87. Google Scholar45. FINLANDLESSES MMF: Q fever: report of a case, New England Jr. Med., 1947, ccxxxvii, 255-257. CrossrefGoogle Scholar46. SPICKNALLHUEBNERFINGERBLOCKER CGRJJAWP: Report of an outbreak of Q fever at the National Institute of Health. I. Clinical features, Ann. Int. Med., 1947, xxvii, 28-40. Google Scholar47. BURNETFREEMAN FMMA: Note on a series of laboratory infections with the rickettsia of Q fever, Med. Jr. Australia, 1939, 11-12. CrossrefGoogle Scholar48. SMITHBROWNDERRICK DJHEEH: A further series of laboratory infections with the rickettsia of "Q" fever, Med. Jr. Australia, 1939, 13-14. CrossrefGoogle Scholar49. ROBBINSRUSTIGIAN FCR: Q fever in the Mediterranean area: report of its occurrence in Allied troops. IV. A laboratory outbreak, Am. Jr. Hyg., 1946, xliv, 67-71. Google Scholar50. Commission on Acute Respiratory Diseases. A laboratory outbreak of Q fever caused by the Balkan grippe strain of Rickettsia burneti , Am. Jr. Hyg., 1946, xliv, 123-157. Google Scholar51. LILLIEPERRINARMSTRONG RDTLC(a) : An institutional outbreak of pneumonitis. III. Histopathology in man and rhesus monkeys in the pneumonitis due to the virus of "Q" fever, Pub. Health Rep., 1941, lvi, 149-155. (b) PERRIN, T. L., and BENGTSON, I. A.: The histopathology of "Q" fever in mice, Pub. Health Rep., 1942, lvii, 790. (c) LILLIE R. D.: Pathologic histology in guinea pigs following intraperitoneal inoculation with the virus of "Q" fever, Pub. Health Rep., 1942, lvii, 296. CrossrefGoogle Scholar52. SPICKNALLHUEBNER CGRJ: Unpublished data. Google Scholar53. BENGTSON IA: Complement fixation in rickettsial diseases. Technique of the test, Pub. Health Rep., 1944, lix, 402-405. CrossrefGoogle Scholar54. HUEBNERTURNER RJH: Unpublished data. Google Scholar55. LENNETTEMEIKLEJOHNTHELEN EHGHM(a) : Treatment of Q fever in man with aureomycin, Ann. N. Y. Acad. Sci., 1948, li, 331-342. (b) HUEBNER, R. J., BELL, J. A., MCNEIL, N., and SHAW, E. W.: Unpublished data. (c) WONG, G. C., and COX, H. R.: Action of aureomycin against experimental and viral infections, Ann. N. Y. Acad. Sci., 1948, li, 290-305. (d) HUEBNER, R. J., HOTTLE, G. A., and ROBINSON, ELEANOR B.: Action of streptomycin in experimental infection with Q fever, Pub. Health Rep., 1948, lxiii, 357-362. (e) SPICKNALL, C. G., TERRY, L. L., and HUEBNER, R. J.: Treatment of Q fever with streptomycin—a case report, Am. Jr. Trop. Med., 1948, xxviii, 845-847. CrossrefGoogle Scholar56. SNYDERSMADELROBBINS MJJEFC: Vaccination against Q fever, Jr. Bact., 1947, liv, 77-78. Google Scholar57. SULKINSTRAUSS SEE: Studies on Q fever: Persistence of complement-fixing antibodies after naturally acquired infection, Proc. Soc. Exper. Biol. and Med., 1948, lxvii, 142-144. CrossrefGoogle Scholar58. HUEBNER RJ: Report of an outbreak of Q fever at the National Institute of Health. II. Epidemiological features, Am. Jr. Pub. Health, 1947, xxxvii, 431-440. CrossrefGoogle Scholar59. PARKERKOHLS RRGM: American Q fever: The occurrence of Rickettsia diaporica in Amblyomma americanum in eastern Texas, Pub. Health Rep., 1943, lviii, 1510-1511. CrossrefGoogle Scholar60. BLANCMARTINMAURICE GLAA: Sur une rickettsia isoles de tiques dans le sud marocain. Son identite probable avec R. burneti agent de la Q fever. Note. Comp. rend. Acad. d. sc., 1946, ccxxiii, 438-439. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: San Francisco, California*Received for publication October 14, 1948.†United States, Panama, Italy, Greece, Switzerland and Algeria.‡A Q Fever Laboratory was established at Hondo, California in September, 1947. Nextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byCoxiellaCoxiella burnetii (Q Fever)Q FeverQ Fever PneumoniaCoxiella burnetii (Q Fever)Dermatoses from ticksSexually Transmitted Q FeverThe radiological appearances of ‘Q’ fever pneumoniaAn Inflammatory Pseudotumor of the Lung in Q Fever PneumoniaThe atypical pneumoniasTHE COURSE OF INFECTION WITH COXIELLA BURNETIMEDICAL AND SURGICAL TREATMENT OF Q-FEVER ENDOCARDITISPathological, rickettsiological and immuno-fluorescence studies of a case of Q fever endocarditisIndependent-Action and Birth-Death Models in Experimental MicrobiologyQ-FieberSOME BIOCHEMICAL CHANGES IN THE GUINEA PIG DURING INFECTION WITH COXIELLA BURNETIISome Considerations of Mites and Ticks as Vectors of Human DiseaseSECTION OF BIOLOGY AND DIVISION OF MYCOLOGY: I. BIOCENOLOGIC PROBLEMS IN IMMUNOLOGY*Q FEVER: REPORT OF A CASE SIMULATING LYMPHOMA*HAROLD S. RAMOS, ROBERT E. HODGES, WILLIAM H. MERONEYHISTORICAL REVIEW OF THE LITERATURE ON Q FEVERQ fever I. Clinical features and laboratory diagnosisEpidemiologische Q-Fieberstudien in Württemberg-HohenzollernReversal of p -Aminobenzoic Acid Inhibition of Growth of Rickettsiae by p -Hydroxybenzoic Acid in Agar-Slant Tissue CultureKlinik der RickettsiosenKlinik der RickettsiosenQ-Fieber in S�dbadenSome recent advances and current problems in the field of rickettsial diseasesQ FeverQ FEVER IN GREAT BRITAIN CLINICAL ACCOUNT OF EIGHT CASESQ FEVER 1 March 1949Volume 30, Issue 3Page: 495-509KeywordsFeversHeadachesInfectious diseasesPneumoniaQ feverResearch laboratoriesRickettsia ePublished: 1 December 2008 Issue Published: 1 March 1949 Copyright & PermissionsCopyright, 1949, by The American College of PhysiciansPDF downloadLoading ...