HYPERTHYROIDISM—AN EVALUATION OF TREATMENT WITH ANTITHYROID DRUGS FOLLOWED BY SUBTOTAL THYROIDECTOMY
Authors: E C BARTELS
Journal: Annals of Internal Medicine (1952)

Article1 December 1952HYPERTHYROIDISM—AN EVALUATION OF TREATMENT WITH ANTITHYROID DRUGS FOLLOWED BY SUBTOTAL THYROIDECTOMYELMER C. BARTELS, M.D., F.A.C.P.ELMER C. BARTELS, M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-37-6-1123 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptSince soon after the discovery of the new antithyroid drugs it appeared that these substances did not have specific curative properties for definitive treatment of hyperthyroidism, we began to use them as preoperative agents. Therefore, most of our patients with hyperthyroidism received one of these agents until a euthyroid state was established and then a radical subtotal thyroidectomy was done. This began a new era in the surgical management of hyperthyroidism.In the past eight and one-half years, 2,400 patients with hyperthyroidism have been treated by this plan. The experience with this sizable group of patients and a careful follow-up...Bibliography1. ColwellSandoLang ARDESJ: Propylthiouracil-induced agranulocytosis, toxic hepatitis, and death, J. A. M. A. 148: 639-641 (Feb. 23) 1952. Livingstone, H. J., and Livingstone, S. F.: Agranulocytosis and hepatocellular jaundice; toxic reactions following propylthiouracil therapy, J. A. M. A. 135: 422-425 (Oct. 18) 1947. Juliar, B., and Harris, T. L.: Fatal agranulocytosis occurring during propylthiouracil therapy; report of a case, J. A. M. A. 139: 646 (Mar. 5) 1949. Beebe, R. T., Propp, S., McClintock, J. C., and Versaci, A.: Fatal agranulocytosis during treatment of toxic goiter with propylthiouracil, Ann. Int. Med. 34: 1035-1040 (Apr.) 1951. CrossrefMedlineGoogle Scholar2. 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HallmanBondy BLPK: Experience with methimazole (Tapazole) in the treatment of hyperthyroidism, Am. J. Med. 11: 724-729 (Dec.) 1951. CrossrefMedlineGoogle Scholar9. Bell GO: Hyperthyroidism, pregnancy and thiouracil drugs, J. A. M. A. 144: 1243-1246 (Dec. 9) 1950. CrossrefMedlineGoogle Scholar10. Astwood EB: The use of antithyroid drugs during pregnancy, J. Clin. Endocrinol. 11: 1045-1056 (Oct.) 1951. CrossrefGoogle Scholar11. DaileyBenson MERC: Hyperthyroidism in pregnancy, Surg., Gynec. and Obst. 94: 103-109 (Jan.) 1952. MedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Boston, Massachusetts*From the Symposium on Thyroid Disease presented at the Thirty-third Annual Session of the American College of Physicians, Cleveland, Ohio, April 23, 1952.From the Department of Internal Medicine of the Lahey Clinic, Boston. 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ROSENBERG, M.D.Zur klinischen Chemie der HypothyreosenUntoward hematologic responses to the antithyroid compoundsAGRANULOCYTOSISTREATMENT OF THYROTOXICOSIS WITH 'NEO MERCAZOLE' (2-CARBETHOXYTHIO-1-METHYLGLYOXALINE) 1 December 1952Volume 37, Issue 6Page: 1123-1134KeywordsDrug discoveryDrugsHyperthyroidismThyroid diseasesThyroidectomy ePublished: 1 December 2008 Issue Published: 1 December 1952 Copyright & PermissionsCopyright, 1952, by The American College of PhysiciansPDF downloadLoading ...