tbuckley/cabot-search huggingface dataset:
Rheumatic Fever: Clinical Manifestations, Etiology, and Treatment
Authors: David Riesman, James Craig Small
Journal: Annals of Internal Medicine (1929)

Article1 January 1929Rheumatic Fever: Clinical Manifestations, Etiology, and TreatmentDAVID RIESMAN, M.D., Sc.D., JAMES CRAIG SMALL, M.D., Sc.D.DAVID RIESMAN, M.D., Sc.D.Search for more papers by this author, JAMES CRAIG SMALL, M.D., Sc.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-2-7-637 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptWe desire to discuss rheumatic fever under three aspects:I. Clinical Manifestations.II. Etiology.III. Treatment.1. The clinical manifestations subsumed under the name of rheumatism are exceedingly numerous. Wiesel (Med. Klin. 1923, xix, 163), found a total of eighty different pathological conditions included under the term rheumatism; we shall limit ourselves to ten, as follows:1. Articular rheumatism or better acute rheumatic fever.2. Some forms of tonsillitis and pharyngitis.3. Chorea minor.4. Cerebral rheumatism or rheumatic hyperpyrexia.5. Certain types of heart disease.6. Certain forms of muscular pains; growing pains in children; some forms of neuritis.... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Philadelphia*Read at the meeting of the American Association of Physicians in Washington, May 1928. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 January 1929Volume 2, Issue 7Page: 637-644KeywordsCardiovascular therapyChildrenEtiologyPharyngitisRheumatic fever ePublished: 1 December 2008 Issue Published: 1 January 1929 PDF downloadLoading ...
Shiga toxin 2a and Enteroaggregative<i>Escherichia coli</i>– a deadly combination
Authors: Nadia Boisen, Angela R Melton-Celsa, Flemming Scheutz, Alison D O'Brien, James P Nataro
Journal: Gut Microbes (2015)

In 2011, a Shiga toxin (Stx) type 2a-producing enteroaggregative E. coli (EAEC) strain of serotype O104:H4 caused a large lethal outbreak in Northern Europe. Until recently, the pathogenic mechanisms explaining the high virulence of the strain have remained unclear. Our laboratories have shown that EAEC genes encoded on the pAA virulence plasmid, particularly the AggR-regulated AAF/I fimbriae, enhance inflammation and enable the outbreak strain to both adhere to epithelial cells and translocate Stx2a across the intestinal epithelium, possibly explaining the high incidence of the life threatening post-diarrheal sequelae of hemolytic uremic syndrome. Epidemiologic evidence supports a model of EAEC pathogenesis comprising the concerted action of multiple virulence factors along with induction of inflammation. Here, we suggest a model for the pathogenesis of the O104:H4 outbreak strain that includes contributions from EAEC alone, but incorporating additional injury induced by Stx2a.
Late Winter Storm
Authors: Judith Strasser
Journal: JAMA (2001)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Effects of medical therapy on outcome assessment using exercise thallium-201 single photon emission computed tomography imaging
Authors: Pierre Y Marie, Nicolas Danchin, Fabrice Branly, Michaël Angioı̈, Alain Grentzinger, Jean M Virion, Benoit Brouant, Pierre Olivier, Gilles Karcher, Yves Juillière, Faı̈ez Zannad, Alain Bertrand
Journal: Journal of the American College of Cardiology (1999)
A new non-linear normalization method for reducing variability in DNA microarray experiments
Authors: Christopher Workman, Lars Juhl Jensen, Hanne Jarmer, Randy Berka, Laurent Gautier, Henrik Bjørn Nielser, Hans-Henrik Saxild, Claus Nielsen, Søren Brunak, Steen Knudsen
Journal: Genome biology (2002)

Microarray data are subject to multiple sources of variation, of which biological sources are of interest whereas most others are only confounding. Recent work has identified systematic sources of variation that are intensity-dependent and non-linear in nature. Systematic sources of variation are not limited to the differing properties of the cyanine dyes Cy(5) and Cy(3) as observed in cDNA arrays, but are the general case for both oligonucleotide microarray (Affymetrix GeneChips) and cDNA microarray data. Current normalization techniques are most often linear and therefore not capable of fully correcting for these effects.We present here a simple and robust non-linear method for normalization using array signal distribution analysis and cubic splines. These methods compared favorably to normalization using robust local-linear regression (lowess). The application of these methods to oligonucleotide arrays reduced the relative error between replicates by 5-10% compared with a standard global normalization method. Application to cDNA arrays showed improvements over the standard method and over Cy(3)-Cy(5) normalization based on dye-swap replication. In addition, a set of known differentially regulated genes was ranked higher by the t-test. In either cDNA or Affymetrix technology, signal-dependent bias was more than ten times greater than the observed print-tip or spatial effects.Intensity-dependent normalization is important for both high-density oligonucleotide array and cDNA array data. Both the regression and spline-based methods described here performed better than existing linear methods when assessed on the variability of replicate arrays. Dye-swap normalization was less effective at Cy(3)-Cy(5) normalization than either regression or spline-based methods alone.
The Bureau of Prohibition: Its History, Activities and Organization.
Authors: Laurence Frederick Schmeckebier
Journal: JAMA (1929)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
An evaluation of the Bender-Gestalt test.
Authors: Alexander Tolor, Herbert C. Schulberg, Lauretta Bender
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
VEGF-C signaling pathways through VEGFR-2 and VEGFR-3 in vasculoangiogenesis and hematopoiesis
Authors: Koichi Hamada, Yuichi Oike, Nobuyuki Takakura, Yasuhiro Ito, Lotta Jussila, Daniel J. Dumont, Kari Alitalo, Toshio Suda
Journal: Blood (2000)
Powdered Alcohol Products
Authors: Timothy S. Naimi, James F. Mosher
Journal: JAMA (2015)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
57. Persistent PEDF Expression Following Intravitreal Administration of High-Capacity Adenovectors
Authors: Sundeep G. Keswani, Anna B. Katz, Elliot B. Kozin, Phillip W. Zoltic, Timothy M. Cromblehome
Journal: Molecular Therapy (2004)

Introduction. Intrauterine growth restriction (IUGR) due to the placental insufficiency is associated with a high morbidity and mortality for which there is no effective therapy. Various growth factors have been suggested to be essential for normal placental function and fetal growth. Among these is insulin like growth factor-1 (IGF-1) which in transgenic knockout mice has proven to result in IUGR. Exogenous IGF-1 protein administration has been ineffective in correcting IUGR. We hypothesize that intraplacental gene transfer will result in sustained high levels of transgene expression and may be more effective in correcting IUGR. In order to test our hypothesis we employed a naturally occurring model of placental insufficiency in the New Zealand Rabbit using intraplacental gene transfer of IGF-1 to correct IUGR due to placental insufficiency.
The use of a murine model of brain death for mechanistic studies on treatment for donor lung injury
Authors: Shana Wauters, Laura Lopopolo, Eric Verbeken, Caroline Meers, Johannes van Loon, Geert Verleden, Dirk Van Raemdonck
Journal: European Respiratory Journal (2011)

Introduction:  Only 15-25% of brain death (BD) donors match the ideal donor criteria for lung transplantation. The mechanisms of BD-related lung injury are not fully understood justifying further research.   Materials and methods:  Brain death in mice was induced by rapid inflation of a subdural balloon catheter.Animals were randomly divided into 4 groups ( n =3 each): 2h sham [S2], 2h BD [BD2], 4h sham [S4], 4h BD [BD4]. Heart rate (HR), mean arterial pressure (MAP) and cortical activity (EEG) were continuously monitored.At the end of the experiment,bronchoalveolar lavage (BAL) was performed and biopsies were collected for histological analysis.   Results:  In both BD groups,the Cushing reflex was characterized by a rapid increase in MAP from induction (85.0mmHg±26.0) to hypertensive peak (121.6mmHg±16.8), with normalization of MAP 10 min after BD confirmation (88.6mmHg±17.0).After BD,HR increased significantly (from 322.8bpm±75.3 to 405.0bpm±75.0) and remained high during the rest of the experiment. In the sham groups,HR and MAP remained constant after balloon insertion. A higher number in BAL neutrophils were seen in [BD4](28.6%±12) compared to [BD2](3.0%±3.0),[S2](1.4%±1.2),and [S4](1.8%±1.6).More neutrophilic infiltration, interstitial oedema and congestion were seen on histology in [BD4](2.7,2.7,and 2.3;respectively) compared to [BD2](1,2,and 2;respectively) and sham (0,0,and 0;respectively).   Conclusion:  The creation of a BD model in mice to study lung injury was successful facilitating further mechanistic studies to attenuate lung injury at immunological level using knock-out animals. A 4-hour period after BD is needed to observe significant inflammatory changes in BAL and lung histology.
Abstract 16515: Detection of Luminal Stenosis by 320-slice CT in Coronary Arteries with Cross Sectional Area Less Than 4mm2 Confirmed by Intravascular Ultrasound Compared with Conventional Coronary Angiogram
Authors: Masae Uehara, Nobusada Funabashi, Yoshio Kobayashi, Hiroyuki Takaoka, Issei Komuro
Journal: Circulation (2010)
Updates in the Treatment of Bone Cancer
Authors: J. Sybil Biermann
Journal: Journal of the National Comprehensive Cancer Network (2013)

Although extremely rare, primary bone cancers are often curable with proper treatment. Effective management of primary bone tumors hinges on the involvement of a multidisciplinary team of physicians with expertise in this area, both in the realms of diagnosis and treatment. In her presentation at the NCCN 18th Annual Conference, Dr. J. Sybil Biermann reviewed the changes to the 2013 NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines) for bone cancer, featuring the introduction of new sections on giant cell tumor of bone (GCTB) and chordoma. The benefits of denosumab for the benign GCTB and the unique challenges associated with the malignant chordoma are also explored.
The Chemical Action of Ultraviolet Rays
Authors: Carleton Ellis, Alfred A. Wells, Francis F. Heyroth
Journal: JAMA (1941)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Semaphorin 4D Contributes to Rheumatoid Arthritis by Inducing Inflammatory Cytokine Production: Pathogenic and Therapeutic Implications
Authors: Yuji Yoshida, Atsushi Ogata, Sujin Kang, Kousuke Ebina, Kenrin Shi, Satoshi Nojima, Tetsuya Kimura, Daisuke Ito, Keiko Morimoto, Masayuki Nishide, Takashi Hosokawa, Toru Hirano, Yoshihito Shima, Masashi Narazaki, Hideki Tsuboi, Yukihiko Saeki, Tetsuya Tomita, Toshio Tanaka, Atsushi Kumanogoh
Journal: Arthritis & Rheumatology (2015)

Semaphorin 4D (Sema4D)/CD100 has pleiotropic roles in immune activation, angiogenesis, bone metabolism, and neural development. We undertook this study to investigate the role of Sema4D in rheumatoid arthritis (RA).Soluble Sema4D (sSema4D) levels in serum and synovial fluid were analyzed by enzyme-linked immunosorbent assay. Cell surface expression and transcripts of Sema4D were analyzed in peripheral blood cells from RA patients, and immunohistochemical staining of Sema4D was performed in RA synovium. Generation of sSema4D was evaluated in an ADAMTS-4-treated monocytic cell line (THP-1 cells). The efficacy of anti-Sema4D antibody was evaluated in mice with collagen-induced arthritis (CIA).Levels of sSema4D were elevated in both serum and synovial fluid from RA patients, and disease activity markers were correlated with serum sSema4D levels. Sema4D-expressing cells also accumulated in RA synovium. Cell surface levels of Sema4D on CD3+ and CD14+ cells from RA patients were reduced, although levels of Sema4D transcripts were unchanged. In addition, ADAMTS-4 cleaved cell surface Sema4D to generate sSema4D in THP-1 cells. Soluble Sema4D induced tumor necrosis factor α (TNFα) and interleukin-6 (IL-6) production from CD14+ monocytes. IL-6 and TNFα induced ADAMTS-4 expression in synovial cells. Treatment with an anti-Sema4D antibody suppressed arthritis and reduced proinflammatory cytokine production in CIA.A positive feedback loop involving sSema4D/IL-6 and TNFα/ADAMTS-4 may contribute to the pathogenesis of RA. The inhibition of arthritis by anti-Sema4D antibody suggests that Sema4D represents a potential therapeutic target for RA.
Interleukin-4-induced transcriptional activation by Stat6 involves multiple serine/threonine kinase pathways and serine phosphorylation of Stat6
Authors: Marko Pesu, Kati Takaluoma, Saara Aittomäki, Anssi Lagerstedt, Kalle Saksela, Panu E. Kovanen, Olli Silvennoinen
Journal: Blood (2000)
351. Enhanced Therapeutic Efficacy of a Cytokine Expressing Oncolytic Herpes Simplex Virus Against Prostate Cancer
Authors: Susan Varghese, Samuel D. Rabkin, Wenzheng Wang, Robert L. Martuza
Journal: Molecular Therapy (2004)

Oncolytic herpes viruses that are currently in the forefront of novel therapeutic strategies exhibit a bimodal antitumoral effect, with direct cytolytic activity and an in situ vaccination effect, whereby virus destruction of tumors activate the host to mount a specific antitumoral immune response. This latter effect is especially relevant considering that many cancers, including, cancer of the prostate, have developed sophisticated mechanisms to evade the host immune system. Thus, strategies to boost the sub-optimal host antitumoral immune response through the exogenous delivery of immunomodulatory cytokines concomitantly during tumor destruction are worth exploring.
Cockroach sensitization mitigates allergic rhinoconjunctivitis symptom severity in patients allergic to house dust mites and pollen
Authors: Weijing He, Fabio Jimenez, Hernan Martinez, Nathan L. Harper, Muthu Saravanan Manoharan, Andrew Carrillo, Puraskar Ingale, Ya-Guang Liu, Seema S. Ahuja, Robert A. Clark, Cynthia G. Rather, Daniel A. Ramirez, Charles P. Andrews, Robert L. Jacobs, Sunil K. Ahuja
Journal: Journal of Allergy and Clinical Immunology (2015)
Differential Regulation of c-myc and Transforming Growth Factor-α Messenger RNA Expression in Poorly Differentiated and Well-Differentiated Colon Carcinoma Cells during the Establishment of a Quiescent State
Authors: Kathleen M. Mulder
Journal: Cancer Research (1991)

A previous report from this laboratory indicated that a transformed fibroblast cell line up-regulated c- myc by as much as 14-fold as cultures approached saturating densities, whereas the untransformed counterparts displayed little alteration in c- myc expression (Cancer Res., 49: 2320, 1989). The results suggested a mechanism for the growth advantage of the transformed cells at postconfluent densities. Similarly, the present results indicate that regulation of c- myc expression during establishment of a quiescent state markedly differed in poorly differentiated versus well-differentiated human colon carcinoma cells. While c- myc expression increased 2- to 3-fold during this period in the poorly differentiated cells, expression levels for this protooncogene showed little variation in the well-differentiated cells. There was, however, no correlation between degree of differentiation and c- myc mRNA levels in growing cultures ( i.e. , cells in late log phase).

Another proliferation-associated mRNA, transforming growth factor α (TGF-α), was also differentially regulated in the two groups of colon carcinoma cells as cultures approached quiescence. Further, addition of exogenous growth-stimulatory factors (epidermal growth factor plus insulin plus transferrin) to quiescent, well-differentiated cells resulted in an up-regulation of TGF-α mRNA levels by 9-fold over a 24-h period. In contrast, poorly differentiated cells displayed little alteration in TGF-α mRNA levels under similar conditions. The results suggest that inappropriate kinetic regulation of c- myc and TGF-α mRNAs at quiescence may be related to the growth factor independence of the poorly differentiated colon carcinoma cells. Furthermore, altered temporal regulation of c- myc and TGF-α expression appears to be more relevant to differentiation status in human colon carcinoma cells than are absolute expression levels.
The Dawn of Modern Medicine. An account of the Revival of the Science and Art of Medicine Which Took Place in Western Europe During the Latter Half of the Eighteenth Century and the First Part of the Nineteenth.
Authors: Albert Henry Buck
Journal: JAMA (1920)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal