tbuckley/cabot-search huggingface dataset:
Abstract P390: Insulin Resistance Determines Severity of Vascular Inflammation by 18-Fluorodeoxy Glucose PET-CT in Psoriasis
Authors: Balaji Natarajan, Taufiq Salahuddin, Jenny Dave, Martin Playford, Julia Doveikis, Peter Herscovitch, Nehal Mehta
Journal: Circulation (2015)

Introduction: Psoriasis (PSO), an inflammatory skin disease is associated with increased cardiovascular disease (CVD) risk. We have previously shown the presence of insulin resistance (IR) in psoriasis, however how this relates to subclinical vascular disease is unknown. Here, our aim was to determine whether IR relates to vascular inflammation (VI) measured by 18 FDG PET-CT in a well-phenotyped psoriasis cohort (NCT 01778569). Hypothesis: We assessed the hypothesis that an increase in IR is associated with greater VI. Methods: We performed 18 FDG PET-CT scans on 86 consecutive patients with psoriasis (Siemens Biograph). Target-to-background ratio (TBR) was used as the VI measure. Fasting plasma samples were collected and homeostatic model assessment of IR (HOMA-IR) was used to stratify the study group into normal (n=41) vs high (n=45) HOMA-IR groups using an accepted cut-off value (3.0). Lipid profile and lipoprotein characteristics were also obtained using NMR spectroscopy (Liposcience, USA). Results: Our study cohort was middle aged with mild to moderate PSO (Table 1). There was increased VI by TBR in this sample (mean 1.8±0.3) as compared to published values for CAD (mean 1.6±0.3). The high HOMA-IR group had greater skin involvement by psoriasis, an increased incidence of CVD risk factors and an atherogenic lipid profile on NMR spectroscopy when compared to the normal HOMA-IR group. There was greater VI in the high HOMA-IR group (Mean±SD: 1.91±0.3 vs 1.69±0.2, p&lt;0.001) which was robust to multivariate adjustment for age, gender, CVD risk factors and BMI (beta 0.38, p &lt;0.01). Finally, on likelihood ratio testing, we observed an incremental effect when HOMA-IR was added to a fully adjusted model with BMI as a covariate (chi 2 5.65, p = 0.02). Conclusion: Psoriasis increases VI by 18 FDG PET-CT, which is strongly related to the presence of IR beyond traditional CVD risk factors and BMI. This suggests that inflammatory IR may have direct impact on the development of vascular inflammation.
Respiratory symptoms correlate with pulmonary inflammation at a time of presumed stability in children with non-ambulant neurodisability
Authors: Ruth Trinick, Anthony M. Dalzell, Paul S. McNamara
Journal: European Respiratory Journal (2011)

Background: Children with non-ambulant neurodisability (ND) often have chronic respiratory symptoms which impact on quality of life and can result in multiple hospital admissions. Respiratory complications are a leading cause of death in this group.

Aims: Assess respiratory symptoms and broncho-alveolar lavage (BAL) inflammatory markers at a time of presumed stability.

Methods: Children with ND and healthy controls were recruited during elective surgical admission. A respiratory symptom score (LRSQ) was completed. BAL was taken at anaesthetic induction. Neutrophil count was recorded (% total cells). IL8 and TGFβ-1 were measured by ELISA. Data are expressed as median [IQR].

Results: 16 children with ND had higher LRSQ scores than 10 controls (21 [5-46] vs. 5 [0-7], p< 0.02). Children with ND had greater BAL neutrophilia (52% [31-71] vs. 4% [3-12], p<0.01) and higher IL8 (516 [0-2465] vs. 0 [0-232] pg/ml, p<0.05). Median TGFβ-1 did not differ (0 vs.0) but the range was markedly different (0-271 vs. 0-73 pg/ml). LRSQ score correlated with BAL neutrophilia (r +0.54, p<0.01), IL8 (r +0.409, p<0.01 and TGFβ-1 (r +0.43, p<0.01). No ND patients had seen a respiratory specialist, 8/16 had undergone video-fluoroscopy (7/8 +ve) and 2/16 took antibiotic prophylaxis.

Conclusions: Children with ND have a high burden of respiratory symptoms which correlate with chronic airway neutrophilia and raised inflammatory cytokines at times of presumed stability. A screening tool to identify those children who would benefit from a specialist respiratory review would be useful. Further research into the potential benefits of prophylactic therapy in this group is needed.
The National Government and Public Health.
Authors: James A. Tobey
Journal: JAMA (1926)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Elevation of serum epidermal growth factor and interleukin 1 receptor antagonist in active psoriasis vulgaris
Authors: K.S. Anderson, S. Petersson, J. Wong, E. Shubbar, N.N. Lokko, M. Carlström, C. Enerbäck
Journal: British Journal of Dermatology (2010)

Psoriatic plaques present a complex expression profile, including high levels of cytokines, chemokines and growth factors. Circulating cytokines have been suggested to reflect the activation status of the inflammatory process.To analyse 20 cytokines, chemokines and growth factors in 14 patients with psoriasis vulgaris at the start and during the course of ultraviolet B treatment.A multiplex cytokine assay was used.We identified increased serum levels of epidermal growth factor (EGF) (mean 323 vs. 36·6 pg mL⁻¹, P = 0·0001), interleukin (IL)-1 receptor antagonist (mean 39·1 vs. 14·6 pg mL⁻¹, P = 0·02) and tumour necrosis factor-α (mean 7·5 vs. 4·5 pg mL⁻¹, P = 0·04) at baseline in patients with psoriasis compared with matched controls. None of these cytokines was correlated to the severity of the disease (Psoriasis Area and Severity Index) or decreased with phototherapy, suggesting that sources other than lesional skin contribute to the production of these cytokines. Using cluster analysis, we observed coordinate upregulation of EGF, IL-6, macrophage inflammatory protein-1ß and vascular endothelial growth factor.The sustained high expression of inflammatory circulating cytokines is a potential mechanism linking psoriasis with its extracutaneous comorbidities.
Sequential administration of gemtuzubab ozogamicin (GO) and intensive chemotherapy for remission induction in previously untreated patients with AML over the age of 60: Interim results of the EORTC leukemia group AML-15A phase II trial
Authors: S Amadori, R Willemze, S Suciu, F Mandelli, D Selleslag, R Stauder, A Ho, C Denzlinger, G Leone, G Fillet, P Muus, J Feingold, F Beeldens, O Anak, T De Witte
Journal: Blood (2001)
Linkage refinement of Bazex-Dupré-Christol syndrome to an 11·4-Mb interval on chromosome Xq25-27.1
Authors: L.J.M.T. Parren, F. Abuzahra, T. Wagenvoort, F. Koene, M.A.M. Van Steensel, P.M. Steijlen, M. Van Geel, J. Frank
Journal: British Journal of Dermatology (2011)

Funding sources: M.A.M.v.S. is supported by the GROW School for Oncology and Developmental Biology and the Dutch Cancer Foundation KWF grant UM2009‐4352. Conflicts of interest: none declared. F.A. and L.J.M.T.P. contributed equally to this manuscript. Madam, Bazex–Dupré–Christol syndrome (BDCS) (OMIM 301845) is a hereditary tumour disorder that was first recognized in 1964 by Bazex et al.1 The disease is characterized by a triad of congenital hypotrichosis; early development of basal cell carcinomas (BCCs) from the first decade onwards; and follicular atrophoderma, most frequently localized on the dorsa of the hands and feet, extensor surfaces of the elbows and knees, and the face. Follicular atrophoderma presents as follicular funnels (so‐called 'ice‐pick marks') due to deep and lax follicular ostia.2 Further symptoms described in patients with BDCS comprise disseminated milia, hyperpigmentation of the forehead, localized hypohidrosis, and hair shaft abnormalities.3, 4 The diagnosis of this rare genodermatosis can be difficult because the clinical symptoms can develop at different ages, with intra‐ and interfamilial phenotypic variation.5 Usually, hypotrichosis is the earliest sign.6 Consequently, the disease has to be differentiated from other genetic disorders manifesting with congenital or early‐onset hair loss such as hypotrichosis simplex and hypohidrotic ectodermal dysplasia.7 Further differential diagnoses of BDCS on the one hand include hereditary tumour syndromes associated with early onset of BCCs such as Gorlin syndrome (OMIM 109400) and Rombo syndrome (OMIM 180730), and on the other hand rare ectodermal dysplasias with proneness to skin tumour development such as, for example, generalized basaloid follicular hamartoma syndrome (OMIM 605827), odonto‐onycho‐dermal dysplasia (OMIM 257980) and Schöpf–Schulz–Passarge syndrome (OMIM 224750).8
Predictors of Treatment Resistance and Relapse in Antineutrophil Cytoplasmic Antibody–Associated Vasculitis: A Study of 439 Cases in a Single Chinese Center
Authors: Zhi‐Ying Li, Dong‐Yuan Chang, Ming‐Hui Zhao, Min Chen
Journal: Arthritis & Rheumatology (2014)

Treatment resistance and relapse in antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) are major challenges for physicians. The aim of this study was to assess the risk factors for treatment resistance and relapse in a single-center cohort of Chinese patients with AAV.Four hundred thirty-nine consecutive patients with AAV were recruited for inclusion in this study. The value of various clinical and pathologic parameters for the prediction of treatment resistance and relapse was analyzed.Treatment resistance occurred in 47 (10.7%) of 439 patients and was independently associated with a higher serum creatinine level (odds ratio [OR] 1.087, 95% confidence interval [95% CI] 1.001-1.180, P = 0.047), a higher erythrocyte sedimentation rate (OR 1.009, 95% CI 1.001-1.018, P = 0.025), therapy with corticosteroids plus cyclophosphamide (OR 0.115, 95% CI 0.051-0.256, P = 0.000), and the presence of muscle pain (OR 0.249, 95% CI 0.083-0.747, P = 0.013). Relapse occurred in 128 (32.7%) of 392 patients in whom remission was achieved and was independently associated with lung involvement (hazard ratio [HR] 1.768, 95% CI 1.088-2.872, P = 0.021) and a lower serum creatinine level (HR 0.925, 95% CI 0.872-0.981, P = 0.009).In Chinese patients with AAV, lung involvement and lower serum creatinine levels were independently associated with an increased risk of relapse. Elevated serum creatinine levels were associated with treatment resistance.
Guidelines for Home- and Office-Based Blood Pressure Monitoring
Authors: Kazuomi Kario, Thomas Pickering
Journal: JAMA (2004)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Abstract 1598: Grainyhead-like 2 (GRHL2) regulates the expression of forkhead box transcription factor M1 (FoxM1) in human oral cancer cells and determines tumorigenicity
Authors: Wei Chen, Jin-Kyu Yi, Ki-Hyuk Shin, Reuben Kim, Shebli Mehrazarin, No-Hee Park, Mo K. Kang
Journal: Cancer Research (2014)

Abstract GRHL2 is a proto-oncogene that regulates epithelial proliferation and differentiation through transcriptional regulation of large number of target genes. The current study was performed to determine its role in oral carcinogenesis through regulation of forkhead box 1 (FoxM1), which is a known oncogene for many solid tumors. GRHL2 expression was highly elevated in oral squamous cell carcinoma (OSCC) tissues compared with normal oral epithelium (NHOM), and its protein expression is localized in the proliferative cells at the outer border of invasive islands of OSCC. In cultured OSCCs, GRHL2 and FoxM1 levels were both highly upregulated compared with normal human oral keratinocytes (NHOK), supporting their roles in oral carcinogenesis. When GRHL2 was knocked down in SCC4 cells by RNA interference, the cells have lost their proliferative capacity and colony formation when plated at low density. GRHL2 knockdown also resulted in marked loss of tumor spheroid formation, which is hallmark of cancer self-renewal. GRHL2 knockdown also led to loss of tumorigenic ability of cells upon xenograft transplantation in immunocompromised mice. GRHL2 appeared to determine the epithelial phenotype in OSCC cells. GRHL2 knockdown led to loss of E-cadherin and miR-200 family genes, which are epithelial markers. These data indicate that GRHL2 is required to maintain the transformed phenotype in OSCC. We also noted that GRHL2 knockdown led to drastic loss of FoxM1 expression, suggesting that GRHL2 may regulate FoxM1. To test this possibility, we performed in vivo binding assay by chromatin immunoprecipitation (ChIP), which showed GRHL2 binding at the proximal promoter of FoxM1. Luciferase reporter plasmid under FoxM1 promoter showed that GRHL2 directly regulates the gene promoter activity. FoxM1 knockdown resulted in loss of OSCC proliferation and tumor spheroid formation, while its overexpression conferred transformed phenotype in non-tumorigenic human oral keratinocytes (HOKs). Therefore, our data indicate that GRHL2 is required for the maintenance of transformed phenotype and that it plays a role in oral carcinogenesis through regulation of FoxM1. This study was supported in part by the grants from NIDCR/NIH (DE18295 and DE18959) and Jack Weichman Endowed Fund. Note: This abstract was not presented at the meeting. Citation Format: Wei Chen, Jin-Kyu Yi, Ki-Hyuk Shin, Reuben Kim, Shebli Mehrazarin, No-Hee Park, Mo K. Kang. Grainyhead-like 2 (GRHL2) regulates the expression of forkhead box transcription factor M1 (FoxM1) in human oral cancer cells and determines tumorigenicity. [abstract]. In: Proceedings of the 105th Annual Meeting of the American Association for Cancer Research; 2014 Apr 5-9; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2014;74(19 Suppl):Abstract nr 1598. doi:10.1158/1538-7445.AM2014-1598
A Health Education Procedure: For the Grades and Grade Teachers.
Authors: Kathleen Wilkinson Wootten
Journal: JAMA (1926)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Relationship between Optical Coherence Tomography–Measured Central Retinal Thickness and Visual Acuity in Diabetic Macular Edema
Authors: David J Browning, Adam R Glassman, Lloyd Paul Aiello, Roy W Beck, David M Brown, Donald S Fong, Neil M Bressler, Ronald P Danis, James L Kinyoun, Quan Dong Nguyen, Abdhish R Bhavsar, Justin Gottlieb, Dante J Pieramici, Michael E Rauser, Rajendra S Apte, Jennifer I Lim, Päivi H Miskala
Journal: Ophthalmology (2006)
Abstract 3533: ADAM9 regulates microRNAs expression for lung cancer metastasis
Authors: Yuh-Pyng Sher, Li-Ju Wang, Mong-Hsun Tsai, Ting-Ting Kuo, Eric Y. Chuang, Liang-Chuan Lai
Journal: Cancer Research (2014)

Abstract Lung cancer is the leading cause of cancer death worldwide, and brain metastasis is a major cause of morbidity and mortality in lung cancer. Currently, it is not clear which molecules or what mechanisms mediate lung cancer brain metastasis. To explore this question, we compared our established brain-metastatic lung cancer sublines with their parental cancer cells, and identified ADAM9 (a disintegrin and metalloprotease 9) was overexpressed in metastatic sublines. Knocking down ADAM9 expression in lung cancer cells also showed significant reduction of lung cancer brain metastasis in vitro and in vivo. Furthermore, using a genome-wide approach to screen ADAM9-related mRNAs and microRNAs involved in brain metastasis, we identified that CDH2, encoding N-cadherin, was up-regulated by ADAM9 in brain-metastatic lung cancer sublines, and the 3′UTR of CDH2 contains the predicted binding sites of several microRNAs that were down-regulated in ADAM9-overexpressed cancer cells. Luciferase assays and western blot analysis showed that CDH2 is a target gene of microRNAs. The up-regulation of microRNAs, in turn, reduced the expression of its target gene and further inhibited the migration ability of aggressive lung adenocarcinoma cells. This study revealed that ADAM9 activates CDH2 through the release of microRNA inhibition of CDH2 in lung adenocarcinoma and plays a role in lung cancer metastasis. Citation Format: Yuh-Pyng Sher, Li-Ju Wang, Mong-Hsun Tsai, Ting-Ting Kuo, Eric Y. Chuang, Liang-Chuan Lai. ADAM9 regulates microRNAs expression for lung cancer metastasis. [abstract]. In: Proceedings of the 105th Annual Meeting of the American Association for Cancer Research; 2014 Apr 5-9; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2014;74(19 Suppl):Abstract nr 3533. doi:10.1158/1538-7445.AM2014-3533
The unique challenges of managing depression in mid‐life women
Authors: LORRAINE DENNERSTEIN, CLAUDIO N. SOARES
Journal: World Psychiatry (2008)

Throughout most of their lives, women are at a greater risk of becoming depressed than men. Some evidence suggests that this heightened risk is associated with increased sensitivity to the hormonal changes that occur across the female reproductive lifecycle. For some women, the peri-menopause and early post-menopausal years may constitute a "window of vulnerability" during which challenging physical and emotional discomforts could result in significant impairment in functioning and poorer quality of life. A number of biological and environmental factors are independent predictors for depression in this population, including the presence of hot flashes, sleep disturbance, history of severe premenstrual syndrome or postpartum blues, ethnicity, history of stressful live events, past history of depression, body mass index and socioeconomic status. This paper explores the current knowledge on the complex associations between mood changes and aging in women. More specifically, the biological aspects of reproductive aging and their impact on mood, psychosocial factors, lifestyle, and overall health are reviewed. In addition, evidence-based hormonal and non-hormonal therapies for the management of depression and other complaints in midlife women are discussed. Ultimately, this article should help clinicians and health professionals to address a challenging clinical scenario: a preventive and effective strategy for the management of depression in the context of the menopausal transition and beyond.
Abstract 2841: Endothelial Selective NF-{kappa}B Inhibition Improves Survival and Preserves Host Defense Capacity in Bacterial Model of Sepsis
Authors: Jianqiang Ding, Xiaobing Ye, Shu F Liu
Journal: Circulation (2007)

NF-κB plays a predominant role in septic pathology and is a desired target for developing therapies for septic shock. However, NF-κB blockade impairs bacterial clearance capability (BCC), which is ...
Colorectal Liver Metastasis Resection Outcomes Defined by Molecular Biology
Authors: Des Winter
Journal: JAMA Surgery (2015)

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The Man Who Shocked the World: The Life and Legacy of Stanley Milgram
Authors: Thomas Blass
Journal: BMJ (2005)

Creator of the famous Obedience Experiments and originator of the six degrees of separation theory, Stanley Milgram transformed our understanding of human nature and continues to be one of the most important figures in psychology and beyond. In this sparkling biography, Thomas Blass captures the colorful personality and pioneering work of a visionary scientist who revealed the hidden workings of our social world. In this new paperback edition, he includes an afterword connecting Milgram's theories to torture, war crimes, and Abu Ghraib.