tbuckley/cabot-search huggingface dataset:
Abstract 2245: Interventional Electrophysiology Studies And Ablation Therapy Under Real Time MRI Guidance - Early Detection Of Complications
Authors: Oliver Ritter, Peter Nordbeck, Florian Fidler, Marcus Warmuth, Karl-Heinz Hiller, Matthias Nahrendorf, Michelle Maxfield, Sabine Wurtz, Wolfgang Geistert, Jens Broscheit, Peter M Jakob, Wolfgang R Bauer
Journal: Circulation (2008)

Background: Cardiac magnetic resonance imaging (MRI) offers 3D real time imaging with unsurpassed soft tissue contrast without X-ray exposure. However, electrophysiological (EP) examinations of patients with rhythm disorders and ablation procedures are still not possible in the MRI environment. To minimize safety concerns and imaging artifacts, we aimed at developing a setup including catheters for interventional EP based on carbon technology. Methods and Results: The setup, which includes a steerable carbon catheter, was tested for safety, image distortion, pacing and sensing properties, and feasibility of ablation at 1.5 Tesla. MR imaging was performed in two different 1.5-T whole-body scanners. To assess unintentional heating of the catheters by radio frequency (RF) pulses of the MR scanner in vitro , a fluoroptic thermometry system was used to record heating at the catheter tip. In vivo tests for pacing and sensing properties and ablation therapy were performed in eight pigs. There was no significant heating of the carbon catheters while using short, repetitive RF pulses from the MR system. Since there was no image distortion when using the carbon catheters, exact targeting of the lesion sites was possible. During imaging, pacing of in vivo pig hearts and sensing the intra cardiac electrogram was possible without any artifacts. Several RF-ablation procedures, including AV node modulation were performed successfully in the scanner. Potential complications during ablation such as perforation of the RV free wall could be monitored in real time as well. Conclusion: Here we describe a newly developed EP technology for interventional electrophysiology based on carbon catheters. These catheters are suitable for electrophysiological diagnostic and ablation procedures. Their feasibility was demonstrated by performing safety EP studies and ablation therapy with carbon catheters in the MRI environment.
MYCN interacts with histone deacetylase to modulate target gene transcription
Authors: Tao Liu, Andrew Tee, Claudia Flemming, Murray D. Norris, Michelle Haber, Glenn M. Marshall
Journal: Cancer Research (2006)

Proc Amer Assoc Cancer Res, Volume 47, 2006

4336 

Oncogenic transcription factor MYCN modulates gene transcription and induces neuroblastoma initiation. Recruitment of histone deacetylase (HDAC) to DNA-bound transcription factors results in removal of acetyl groups from nucleosomal histones, tightening of nucleosomal integrity, and suppression of transcription, particularly of tumor suppressor genes. Reversely, dissociation of HDAC from transcription factors inactivates HDAC enzyme. We have carried out experiments to investigate whether MYCN interacts with HDAC to exert transcriptional regulation. cDNA microarray indicated that MYCN over-expression suppressed tissue transglutaminase (TGM2) gene expression by 40 folds in SHEP S1 MYCN stable transfectants, compared with SHEP EV empty vector control. This transcriptional regulation was further confirmed in tetracycline withdrawal-inducible MYCN-expressing SHEP cells (SHEP TET-OFF). The down-regulation of TGM2 and promotion of cell proliferation by MYCN in SHEP S1 cells was reversed by intervention with TSA, a specific inhibitor of HDAC. Small interfering RNA (siRNA) targeting TGM2 knocked out TGM2 gene expression, and promoted proliferation of SHEP EV, SHEP TET-OFF, but not SHEP S1 cells without TSA treatment. TGM2 siRNA also partly blocked TSA-induced SHEP S1 cell growth inhibition. HDAC enzymatic assay indicated that MYCN up-regulation correlated with increased HDAC enzymatic activity in the cells. Furthermore, competitive RT-PCR revealed that down-regulation of TGM2 correlated with advanced tumor stages, and Kaplan-Meiers analysis demonstrated that down-regulation of TGM2 predicted poor clinical prognosis in 31 neuroblastoma tissue samples from patients. In conclusion, MYCN interacts with HDAC to modulate target gene transcription, and to promote cell proliferation through down-regulation of TGM2.
Deficiency of Vitamin A in Students
Authors: S. Doraiswami, J. Yudkin
Journal: BMJ (1948)

BDI ¶rfj'SHRNALThis request was refused, and the experiments were there- fore terminated.The refusal was based upon the contention that unless preliminary experiments were undertaken to test the effects of optimum volu-me and concentration of H 11 upon M 63 and C 3H tumours the results would be valueless.After considerable thought had been given to this suggestion it was decided that no useful purpose would be served by undertaking dosage experiments.SummaryEvidence is presented that grafted Twort mammary carcinoma is not a satisfactory tumour upon which to test a chemotherapeutic substance for growth-inhibitory properties.This statement is based upon extensive attempts to propagate this tumour, which often does not take and has a high regression rate (Table I).No gro,wth-inhibiting effect of H 11 could be demonstrated in experiments in which grafted Twort carcinoma was the test tumour (Table II) nor in experiments in which a grafted spindle-cell sarcoma in homologous mice was tested (Table III).H 11 had no effect on the growth rate of spontaneous mammary cancer in inbred mice as compared with that of similar untreated tumours (Table IV).New tumours were not prevented from arising, and metastasis took place in spite of the treatment.Grateful acknowledgment is due to Dr. E. C. Armstrong and Dr. W. J. Martin: to the former for much
College inquiry finds evidence of “dysfunctional relationship”
Authors: Gavin Foster
Journal: BMJ (2000)

An inquiry by the Royal College of Physicians into treatment given to patients with heart disease on the Isle of Wight raised criticisms in more than a third of the 31 cases examined.

The inquiry was carried out after consultant physician Dr Anthony Bainbridge criticised the care given to cardiac patients by some of his colleagues. Dr Bainbridge was later suspended on full pay from his job.

Prolonged negotiations over his future, …
Risk factors for sporadic listeriosis in the Netherlands, 2008 to 2013
Authors: I H Friesema, S Kuiling, A van der Ende, M E Heck, L Spanjaard, W van Pelt
Journal: Eurosurveillance (2015)

Although the disease burden of listeriosis on population level is low, on individual level the impact is high, largely due to severe illness and a high case fatality. Identification of risk factors supports and specifies public health actions needed for prevention. We performed a case–control study to determine host- and food-related risk factors for non-perinatal listeriosis in the Netherlands. Patients with non-perinatal listeriosis reported between July 2008 and December 2013 were compared with controls from a periodic control survey who completed a questionnaire in the same period. Higher age, male sex, underlying disease, especially cancer and kidney disease, and use of immunosuppressive medicine were strong risk factors for acquiring non-perinatal listeriosis. Analysis of the food consumption in the group of cases and controls with underlying diseases did not reveal any high-risk food products. Information and advice should continue to be given to persons at risk of severe listeriosis. Univariate analyses indicate that patients using gastric acid inhibitors are at risk. It is worth adding these patients to the group of susceptible persons.
Enhanced cytotoxicity of CZ48, a lactone-stablized C20-propionate, by farnesyltransferase inhibitor in lung cancer cell lines
Authors: Diana S.-L. Chow, Dong Liang, Leah Cho, Sai-Ching J. Yeung, Beppino Giovanella
Journal: Cancer Research (2005)

Proc Amer Assoc Cancer Res, Volume 46, 2005

4942 

Objective. CZ48, a lactone-stablized camptothecin-C20-propionate, exerts S-phase specific cytotoxicity after its hydrolysis to camptothecin. Manumycin A (MA), a farnesyltransferase inhibitor, induces cell rest at G1 phase. This study was to test the hypothesis that the cytotoxic activity of CZ48 in lung cancer cell lines could be enhanced by MA through the combination of the distinct cell cycle-specific activities of the two agents. Methods. CZ48 was evaluated at 0.103-25 μM alone, or in combination with MA at 0.25-25 μM for cytotoxicity in five human non-small cell lung cancer cell (NSCLC) lines, H1734 (adenocarcinoma, p53 wild type), H522 (adenocarcinoma, p53 mutated), H460 (pleural effusion, p53 wild type), H358 (bronchioalveolar carcinoma, p53 null) and H2444 (epithelial NSCLC from non-smoker). Cells of 2x104/100 μl medium were inoculated in 96-well plates and incubated at 37oC for 24 hr. CZ48 with or without MA were added and incubated with the cells for 48 hr. The cell survival in each well was monitored by XTT assay. The cell line sensitivity to cytotoxicity of CZ48 was established by IC50 for each cell line. The enhancing effect of MA on the cytotoxicity of CZ48 was characterized for individual cell lines. Results. H1734 was most sensitive to CZ48 treatment with IC50 of 0.8 μM, followed by H358 of 15 μM. The remaining three lines, H2444, H522 and H460 were insensitive to CZ48 treatments with IC50 of > 25 μM. The IC50 of MA in these lines were 10, 10.5, 15, 4 and 6 μM, respectively. The cytotoxicity of CZ48 was significantly enhanced by MA. The IC50 values of CZ48 were reduced from 0. 8 to 0.3 μM with 3 μM of MA in H1734; and from 15 to 2.8, 0.9, 0.3 and 0.1 μM with 0.7, 1, 1.7 and 2 μM of MA, respectively, in H358. The IC50 in insensitive lines were substantially reduced from 25 μM to 0.3 μM with 10.5 μM of MA in H2444, 0.9 μM with 3 μM of MA in H522, and 0.3 μM with 3.5 μM of MA in H460. Conclusions. The combination of CZ48 with MA exerts significant enhanced cytotoxic effects on the five NSCLC lines with various etiology and p53 expressions, and warrants further in vivo evaluations.
Preferential loss of gut-homing α4β7 CD4+ T cells and their circulating functional subsets in acute HIV-1 infection
Authors: Xiaofan Lu, Zhen Li, Qunhui Li, Yanmei Jiao, Yunxia Ji, Hongwei Zhang, Zhuoming Liu, Wei Li, Hao Wu
Journal: Cellular and Molecular Immunology (2015)
Global regulations on diabetics treated with insulin and their operation of commercial motor vehicles
Authors: T. Songer, M. Marti, M. De Sereday, M. Cohen, Paul Zimmet, E. Schober, C. Vandewalle, P. Van Crombrugge, G. Krzentowski, L. Franco, L. Iochida, S. Ferreira, M. Vivolo, J. Ekoe, E. Carrasco, G. Lopez, J. Tuomilehto, C. Bartsocas, N. Papazoglou
Journal: BMJ (1993)
Abstract 963: Metabolic Syndrome is Characterized by Ventriculo-Arterial Mismatch with Disproportionate Increase of End-systolic Ventricular Stiffness
Authors: Vojtech Melenovsky, Paul D Chantler, Farzad Majidi, Luigi Ferucci, David A Kass, Edward G Lakatta, Samer S Najjar
Journal: Circulation (2007)

Objective: Ventricular end-systolic stiffness (Ees) reflects the contractile behavior of the left ventricle, geometry and mass. In subjects without heart disease, Ees is matched to arterial load (arterial elastance, Ea) so that ventriculo-vascular coupling is preserved and cardiac performance optimized. However, it remains unknown whether metabolic syndrome (MS) affects the coupling ratio (Ees/Ea). Methods : Ea and Ees were non-invasively estimated by single-beat methods based on resting echocardiography and blood pressure data from 176 participants (age 64±13 y, 51% females) in the Baltimore Longitudinal Study of Aging. Presence (+) or absence (−) of MS and the MS score were defined by ATP III-NCEP. Results: MS+ subjects had higher Ees/Ea ratio than MS - (2.1 vs. 1.9, p=0.02) due to higher Ees (3.1 vs. 2.6 mmHg/ml, p=0.002), even if adjusted to body size. Vascular load (Ea, 1.5 vs. 1.4 mmHg/ml, p=0.07), LV mass, age, gender were similar (p&gt;0.1) in both groups, but pulse pressure and relative LV wall thickness were higher in MS+. Ees/Ea and Ees correlated with MS score (r=0.18 and 0.27, p=0.02 and &lt;0.001) and plasma leptin level (r=0.31 and 0.20, p&lt;0.001 and 0.02). From individual MS components, Ees/Ea was most affected by waist circumferrence. Ees and Ees/Ea predicted attained peak VO 2 (r= − 0.33 and − 0.29, p&lt;0.001), being lower in MS+ (19±6 vs. 25±6 ml/kg/min, p&lt;0.001). Conclusions: In MS, ventricular end-systolic stiffening rises beyond that predicted by arterial load. Leptin and other endocrine factors related to central obesity may be implicated in disproportionate increase of Ees. Abnormal coupling and low systolic reserve likely contribute to exercise intolerance in MS.
Investigation of Tuberculosis in a High School — San Antonio, Texas, 2012
Authors: Tommy L. Camden, Dora Maruffo, Norma Santos, John J. Nava, Carlos Alcantara
Journal: MMWR Morbidity and Mortality Weekly Report (2015)

On February 21, 2012, the San Antonio Metropolitan Health District (SAMHD) Tuberculosis Clinic was notified that two students at Madison High School had laboratory-confirmed pulmonary tuberculosis (TB). During March-September 2012, public health officials from SAMHD collaborated with the school district to conduct an outbreak investigation that included performing tuberculin skin tests (TSTs) on high-risk contacts of active TB patients. To ensure compliance, all TSTs were performed at the school. Initial screening was conducted as soon as a contact was identified and was followed by a second TST ≥8 weeks after the patients with active TB were removed from the school. All positive TSTs were confirmed with an interferon gamma release assay (IGRA) (T-Spot.TB, Oxford Immunotec, Inc.) performed by SAMHD laboratory services. IGRA tests can provide additional evidence of infection to encourage acceptance and adherence of foreign-born patients who believe their positive TST is attributable to Bacille Calmette-Guerin vaccination and might also prompt greater acceptance of treatment for latent TB infection compared with a positive TST alone.
Randomized Comparison of DAT Versus ADE as Induction Chemotherapy in Children and Younger Adults With Acute Myeloid Leukemia. Results of the Medical Research Council's 10th AML Trial (MRC AML10)
Authors: Ian M. Hann, Richard F. Stevens, Anthony H. Goldstone, John K.H. Rees, Keith Wheatley, Richard G. Gray, Alan K. Burnett
Journal: Blood (1997)
Abstract 1047: Infusion of Reconstituted High Density Lipoproteins Into Humans Enhances the In Vitro Anti-Inflammatory Capacity of the High Density Lipoprotein Fraction.
Authors: Sanjay Patel, Brian Drew, Stephen Duffy, Shirley Nahkla, Kerry-Anne Rye, Philip Barter, David Celermajer, Bronwyn Kingwell
Journal: Circulation (2007)

Background: Intravenous infusions of reconstituted high density lipoproteins (rHDL) have been shown to promote regression of coronary atheroma. Here we investigate the effects of rHDL infusion on the anti-inflammatory capacity of the isolated HDL fraction. Methods: Eight fasting Type 2 Diabetics (mean age 52 ± 2 years) received IV saline or apolipoprotein A-I (apoA-I)/phosphatidylcholine complexes (rHDL) at an apoA-I dose of 80mg/kg, on separate occasions in random order. The HDL fraction was isolated from subjects at baseline, 4 &amp; 72hrs after infusion and assayed for chemical composition. The anti-inflammatory capacity of HDL preparations was assessed by incubation for 16hrs with human coronary artery endothelial cells. Cell expression of vascular cell adhesion molecule-1 (VCAM-1) and inter-cellular adhesion molecule (ICAM-1) 5 hrs after TNF-α stimulation was quantitated by flow cytometry. Results : Saline infusion had no effect on concentration or anti-inflammatory capacity of isolated HDL. rHDL infusion increased the concentration of HDL apoA-I (at baseline, 4h &amp; 72h, [apoA-I] = 966 ± 105, 2562 ± 330 &amp; 1701 ± 180 (ug/mL) respectively), as well as HDL cholesterol and HDL phospholipids. The addition of equivalent volumes of HDL (100uL) isolated at each time point inhibited VCAM-1 (Panel A) and ICAM-1 (Panel B) expression in proportion to the apoA-I concentration of the isolated HDL (p&lt;0.01 ANOVA across time points for both VCAM-1/ICAM-1 expression and apoA-I concentration) (see figure ). Conclusions: Infusion of rHDL in humans increases the concentration of HDL apoA-I. The anti-inflammatory capacity of isolated HDL is enhanced in proportion to its apoA-I concentration.
Peptide Receptor Radionuclide Therapy–Induced Hepatotoxicity in Patients With Metastatic Neuroendocrine Tumors
Authors: Brian P. Riff, Yu-Xiao Yang, Michael C. Soulen, Daniel A. Pryma, Bonita Bennett, Damian Wild, Guillaume Nicolas, Ursina R. Teitelbaum, David C. Metz
Journal: Clinical Nuclear Medicine (2015)

Background Treatment of metastatic gastroenteropancreatic neuroendocrine tumors (GEP-NETs) with peptide receptor radionuclide therapy (PRRT) is effective in retarding tumor growth. Renal dysfunction, anemia, and thrombocytopenia are well-described treatment-related toxicities. However, hepatotoxicity is not well recognized. Patients and Methods We performed a retrospective cohort study of consecutive patients with GEP-NETs seen in a tertiary NET clinic from January 2010 to September 2013 (n = 211) with the primary study cohort being patients with metastatic disease to the liver (n = 93). The study exposure was PRRT, and the primary outcome of interest was hepatotoxicity. Hepatotoxicity was defined as a grade 2 or greater injury according to the Common Terminology Criteria for Adverse Events version 3.0 of the National Cancer Institute. Results Seventeen (18%) of 93 patients with liver metastases received PRRT after radiographic confirmation of disease progression despite receipt of other traditional therapies. Peptide receptor radionuclide therapy patients were similar to the unexposed patient population in terms of sex, age, baseline laboratory values, prior treatment exposure, and duration of disease. In the unexposed group, 23 (30%) of 76 patients had hepatotoxicity related to traditional GEP-NET therapy. In the exposed group, 10 (59%) of 17 patients had an episode of hepatotoxicity. Ascites developed in 59% of the PRRT group versus 6.6% in the unexposed group (P < 0.001). The calculated relative risk of hepatotoxicity related to PRRT exposure in metastatic GEP-NET patients was 1.94 (95% confidence interval, 1.15–3.28). Conclusions Hepatotoxicity after PRRT for metastatic GEP-NET is more common than previously reported.
Abstract 79: The Predictive Value of NT-pro BNP in Cardiac Arrest Patients Treated with Mild Hypothermia
Authors: Jung HeeWee, Jeong HoPark, Chun SongYoun, Kyu NamPark, Seung PillChoi
Journal: Circulation (2012)

Background There has not been accurate, independent biomarker to reliably predict neurological outcome in cardiac arrest survivors. B-type natriuretic peptide (BNP) has both prognostic and diagnostic value in heart diseases, and many studies showed NT-pro BNP had more accurate than BNP. We speculated that NT-pro BNP measured after restoration of spontaneous circulation (ROSC) may predict patient outcome. Methods & Results A retrospective review of comatose survivors who were treated with mild therapeutic hypothermia after cardiac arrest due to cardiac origin to two tertiary general hospitals between June 2007 and May 2011 was performed. NT-pro BNP level was checked in 87 patients immediately after ROSC. 35 (40.0%) had a favorable neurological outcome (cerebral performance category 1, 2) and 53 (60.9%) showed survival discharge. The mean value of NT-pro BNP was 557.1±1327.9pg/ml and 5,541.7±9,758.9pg/ml in favorable and unfavorable outcome, respectively (p=0.001). The AUC for favorable neurological outcome...
Somatic Mutation Spectrum of Non–Small-Cell Lung Cancer in African Americans: A Pooled Analysis
Authors: Luiz H. Araujo, Philip E. Lammers, Velmalia Matthews-Smith, Rosana Eisenberg, Adriana Gonzalez, Ann G. Schwartz, Cynthia Timmers, Konstantin Shilo, Weiqiang Zhao, Thanemozhi G. Natarajan, Jianying Zhang, Ayse Selen Yilmaz, Tom Liu, Kevin Coombes, David P. Carbone
Journal: Journal of Thoracic Oncology (2015)
Adverse Effects of ACE Inhibitors
Authors: Theodore J. Chu
Journal: Annals of Internal Medicine (1993)

Letters15 February 1993Adverse Effects of ACE InhibitorsTheodore J. Chu, MD and Norman Chow, MDTheodore J. Chu, MDSearch for more papers by this author and Norman Chow, MDSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-118-4-199302150-00020 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:A wide range of adverse effects such as cough and angioneurotic edema [1] may result from the use of ACE inhibitors [2]. Rarely, angioedema has been reported to occur up to 3 years after initiation of therapy [3]. We describe a patient who took captopril for 7 years before onset.A 55-year-old woman who had taken captopril, 25 mg thrice daily, for hypertension since 21 August 1984 had two episodes of moderate tongue swelling in August and September 1991, respectively. On 14 October 1991, she awoke with a severely swollen tongue. Examination showed that she was drooling, ...References1. Israili ZH, Hall WD. Cough and angioneurotic edema associated with angiotensin-converting enzyme inhibitor therapy. Ann Intern Med. 1992; 117:234-42. Google Scholar2. Weber MA. Safety issues during antihypertensive treatment with angiotensin converting enzyme inhibitors. Am J Med. 1988; 84(Suppl 4A):16-23. Google Scholar3. Chin HL, Buchan DA. Severe angioedema after long-term use of an angiotensin-converting enzyme inhibitor (Letter). Ann Intern Med. 1990; 112:312-3. Google Scholar Author, Article, and Disclosure InformationAuthors: Theodore J. Chu, MD; Norman Chow, MD PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byAntihypertensive DrugsIncidence and Predictors of Angioedema in Elderly Hypertensive Patients at High Risk for Cardiovascular Disease: A Report From the Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial (ALLHAT)Adverse Dermatologic Effects of Cardiovascular Drug Therapy: Part IIAngiotensin-converting enzyme (ACE) inhibitors and angio-oedemaAngiotensin converting enzyme inhibitors and the otolaryngologistCaptopril 15 February 1993Volume 118, Issue 4 Page: 314-315 Keywords ACE inhibitors Drug therapy Edema Emergency department Epinephrine Esterases Food allergies Hypertension Inflammation Tongue ePublished: 15 August 2000 Issue Published: 15 February 1993 Copyright & PermissionsCopyright © 1993 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Bed Bugs
Authors: Carolyn J. Hildreth
Journal: JAMA (2009)

Bed BugsB ed bugs, Cimex lectularius, have been around for thousands of years.They are a human parasite (organism living in, with, or on another organism) from the insect family Cimicidae, which thrives in temperate and tropical regions worldwide.Bed bugs are exclusively hematophagous (they feed only on blood).They are small but visible to the naked eye, wingless, yellow to reddish brown in color, oval shaped, and have prominent eyes.They can hide in the cracks and crevices of mattresses, in box springs, on the backboards of beds, and behind loose wallpaper baseboards, and they can travel in furniture, luggage, clothing, and other personal belongings.The stigma commonly associated with bed bugs is mostly unwarranted because infestation is not necessarily attributable to lack of hygiene.International travel, immigration, and resistance to insecticides have contributed to a resurgence in reports of infestations with these insects in developed countries.Bed bugs are predominantly night feeders, attracted to warm-blooded animals, including humans.There is currently no scientific evidence that these blood-sucking insects spread diseases such as human immunodeficiency virus (HIV).The April 1, 2009, issue of JAMA includes an article about bed bugs.