tbuckley/cabot-search huggingface dataset:
Five-Year Clinical and Angiographic Outcomes of a Randomized Comparison of Sirolimus-Eluting and Paclitaxel-Eluting Stents
Authors: Lorenz Räber, Lea Wohlwend, Mathias Wigger, Mario Togni, Simon Wandel, Peter Wenaweser, Stéphane Cook, Aris Moschovitis, Rolf Vogel, Bindu Kalesan, Christian Seiler, Franz Eberli, Thomas F. Lüscher, Bernhard Meier, Peter Jüni, Stephan Windecker
Journal: Circulation (2011)

Long-term comparative data of first-generation drug-eluting stents are scarce. We investigated clinical and angiographic outcomes of sirolimus-eluting (SES) and paclitaxel-eluting stents (PES) at 5 years as part of the Sirolimus-Eluting Versus Paclitaxel-Eluting Stents for Coronary Revascularization (SIRTAX) LATE study.A total of 1012 patients were randomly assigned to SES or PES. Repeat angiography was completed in 444 of 1012 patients (43.8%) at 5 years. Major adverse cardiac events occurred in 19.7% of SES- and 21.4% of PES-treated patients (hazard ratio, 0.89; 95% confidence interval, 0.68 to 1.17; P=0.39) at 5 years. There were no differences between SES and PES in terms of cardiac death (5.8% versus 5.7%; P=0.35), myocardial infarction (6.6% versus 6.9%; P=0.51), and target lesion revascularization (13.1% versus 15.1%; P=0.29). Between 1 and 5 years, the annual rate of target lesion revascularization was 2.0% (95% confidence interval, 1.4% to 2.6%) for SES and 1.4% (95% confidence interval, 0.9% to 2.0%) for PES. Among patients undergoing paired angiography at 8 months and 5 years, delayed lumen loss amounted to 0.37 ± 0.73 mm for SES and 0.29 ± 0.59 mm for PES (P=0.32). The overall rate of definite stent thrombosis was 4.6% for SES and 4.1% for PES (P=0.74), and very late definite stent thrombosis occurred at an annual rate of 0.65% (95% confidence interval, 0.40% to 0.90%).Long-term follow-up of first-generation drug-eluting stents shows no significant differences in clinical and angiographic outcomes between SES and PES. The continuous increase in late lumen loss in conjunction with the ongoing risk of very late stent thrombosis suggests that vascular healing remains incomplete up to 5 years after implantation of first-generation drug-eluting stents.
THE INFLUENCE THAT SERUM EXERTS UPON TRYPANOSOMES, WITH SPECIAL REFERENCE TO ITS USE FOR EXPERIMENTS IN VITRO WITH ATOXYL AND PARAMINO-PHENYLARSENOXYD
Authors: B. T. Terry
Journal: The Journal of Experimental Medicine (1915)

1. Serum of various animals preserves the motility of nagana trypanosomes better and longer than salt solution. 2. To act best in this way the serum should not be diluted more than 2 to 4 times. Undiluted serum is perhaps best. 3. Serum filtered through a Berkefeld filter, bottled aseptically, and kept in the ice box preserves this activating property apparently undiminished for many months. 4. Serum preserves the motility of trypanosomes better than "Sals physiologicum" of Merck, and better than the Ringer solutions of Meltzer and Carrel. 5. Serum preserves the normal morphology of trypanosomes better than the Ringer solutions tested. 6. The infectiousness of trypanosomes suspended in cattle serum was preserved at room temperature for at least 8 days. 7. The vitality of the trypanosomes in serum was seemingly better preserved at room temperature than at ice box temperature. 8. Serum incubated with atoxyl does not transform it into a toxic substance. 9. Serum does not bind paraminophenylarsenoxyd, for trypanosomes suspended in serum are often immobilized more quickly by paraminophenylarsenoxyd than trypanosomes suspended in salt solution. 10. Serum is suitable for suspending trypanosomes for certain experiments in vitro, and with proper precautions may be employed for transporting virus from laboratory to laboratory.
Metabolic Regulation of Heme Catabolism and Bilirubin Production. I. HORMONAL CONTROL OF HEPATIC HEME OXYGENASE ACTIVITY
Authors: Arne F. Bakken, M. Michael Thaler, Rudi Schmid
Journal: Journal of Clinical Investigation (1972)

Heme oxygenase (HO), the enzyme system catalyzing the conversion of heme to bilirubin, was studied in the liver and spleen of fed, fasted, and refed rats. Fasting up to 72 hr resulted in a threefold increase in hepatic HO activity, while starvation beyond this period led to a gradual decline in enzyme activity. Refeeding of rats fasted for 48 hr depressed hepatic HO activity to basal values within 24 hr. Splenic HO was unaffected by fasting and refeeding.
Abstract 3356: Temozolomide resistance in human glioblastoma is associated with marked increase in PDK1 and MGMT expression
Authors: William Lee, Kiran Kumar Velpula, Andrew J. Tsung
Journal: Cancer Research (2014)

Abstract Temozolomide has become the standard of care in glioblastoma (GBM) treatment, but a significant number of patients despite optimal treatment are met with recurrence. It is important to understand the molecular mechanisms underlying TMZ resistance for the development of better treatment strategies. In the present study, we evaluated the dynamic relationship between MGMT and resistance to TMZ. We generated a TMZ-resistant 5310R cell line by continuous treatment with 100 µM concentrations of TMZ (3 months) to parent 5310 cells. We tested the efficacy of TMZ on 5310R cells by FACS analysis. 5310R cells showed increased expression of MGMT when compared to parental controls. Also, we observed that the 5310R cells showed alterations in cell morphology, enhanced cell adhesion, increased migration and invasion capacities. Moreover, we observed PDK1, MGMT and EGFR expression to be up-regulated in 5310R cells compared to parental controls. Our previous data suggested that inhibition of PDK1 reverses the Warburg effect, and here we demonstrate that the acquired TMZ resistance in glioma may be associated with promotion of the malignant phenotype. Furthermore, we observed a significant correlation between PDK1, MGMT and EGFR expression in human GBM specimens using immunohistochemistry and Western blot analysis. As treatment with TMZ becomes more ubiquitous in GBM treatment, the significance of the resistant 5310R cell line and an understanding of the metabolic and epigenetic changes will become critical in the development of targeted and effective therapies. Citation Format: William Lee, Kiran Kumar Velpula, Andrew J. Tsung. Temozolomide resistance in human glioblastoma is associated with marked increase in PDK1 and MGMT expression. [abstract]. In: Proceedings of the 105th Annual Meeting of the American Association for Cancer Research; 2014 Apr 5-9; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2014;74(19 Suppl):Abstract nr 3356. doi:10.1158/1538-7445.AM2014-3356
Cutaneous GVHD is associated with the expansion of tissue-localized Th1 and not Th17 cells
Authors: Raewyn Broady, Jie Yu, Vickie Chow, Adisak Tantiworawit, Christine Kang, Kyra Berg, Magdalena Martinka, Mehran Ghoreishi, Jan Dutz, Megan K. Levings
Journal: Blood (2010)
Hepatitis C virus protein expression causes calcium-mediated mitochondrial bioenergetic dysfunction and nitro-oxidative stress
Authors: Claudia Piccoli, Rosella Scrima, Giovanni Quarato, Annamaria D'Aprile, Maria Ripoli, Lucia Lecce, Domenico Boffoli, Darius Moradpour, Nazzareno Capitanio
Journal: Hepatology (2007)

Hepatitis C virus (HCV) infection induces a state of oxidative stress that is more pronounced than that in many other inflammatory diseases. In this study we used well-characterized cell lines inducibly expressing the entire HCV open-reading frame to investigate the impact of viral protein expression on cell bioenergetics. It was shown that HCV protein expression has a profound effect on cell oxidative metabolism, with specific inhibition of complex I activity, depression of mitochondrial membrane potential and oxidative phosphorylation coupling efficiency, increased production of reactive oxygen and nitrogen species, as well as loss of the Pasteur effect. Importantly, all these effects were causally related to mitochondrial calcium overload, as inhibition of mitochondrial calcium uptake completely reversed the observed bioenergetic alterations.Expression of HCV proteins causes deregulation of mitochondrial calcium homeostasis. This event occurs upstream of further mitochondrial dysfunction, leading to alterations in the bioenergetic balance and nitro-oxidative stress. These observations provide new insights into the pathogenesis of hepatitis C and may offer new opportunities for therapeutic intervention.
Care at the End of Life
Authors: Laura C. Hanson, Marion Danis, James A. Tulsky
Journal: Annals of Internal Medicine (1997)

Letters1 October 1997Care at the End of LifeLaura C. Hanson, MD, MPH, Marion Danis, MD, and James A. Tulsky, MDLaura C. Hanson, MD, MPHUniversity of North Carolina; Chapel Hill, NC 27599Veterans Affairs Medical Center; Durham, NC 27705Search for more papers by this author, Marion Danis, MDUniversity of North Carolina; Chapel Hill, NC 27599Veterans Affairs Medical Center; Durham, NC 27705Search for more papers by this author, and James A. Tulsky, MDUniversity of North Carolina; Chapel Hill, NC 27599Veterans Affairs Medical Center; Durham, NC 27705Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-127-7-199710010-00021 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail IN RESPONSE:These letters highlight two of the most promising strategies for innovation in end-of-life care. Although mentioned in our discussion, improvements in communication skills and palliative care services deserve special emphasis.Gertner and colleagues discuss the limitations of advance directives that focus on specific treatment decisions. They encourage physicians to share more information on diagnosis and prognosis and to search out the patient's values and goals for treatment. In this manner, the content of advance planning discussions can move away from the technical details of treatment choices and focus on designing treatment to meet a patient's true needs. We ...References1. A controlled trial to improve care for seriously ill hospitalized patients. The study to understand prognoses and preferences for outcomes and risks of treatments (SUPPORT). The SUPPORT Principal Investigators. JAMA. 1995; 274:1591-8. Google Scholar2. Schneiderman LJ, Kromick R, Kaplan RM, Anderson JP, Langer RD. Effects of offering advance directives on medical treatments and costs. Ann Intern Med. 1992; 117:599-606. Google Scholar3. Hanson LC, Danis M, Garrett J. What is wrong with end of life care? Opinions of bereaved family. J Am Geriatr Soc. [In press]. Google Scholar Author, Article, and Disclosure InformationAuthors: Laura C. Hanson, MD, MPH; Marion Danis, MD; James A. Tulsky, MDAffiliations: University of North Carolina; Chapel Hill, NC 27599Veterans Affairs Medical Center; Durham, NC 27705 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 October 1997Volume 127, Issue 7Page: 574-575KeywordsEnd of life careHealth careNursing homesPalliative carePatientsResuscitation ePublished: 15 August 2000 Issue Published: 1 October 1997 Copyright & PermissionsCopyright © 1997 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
A possible paracrine hedgehog signalling pathway in neurofibromas from patients with neurofibromatosis type 1
Authors: H. Endo, A. Utani, F. Matsumoto, T. Kuroki, S. Yoshimoto, M. Ichinose, H. Shinkai
Journal: British Journal of Dermatology (2003)

Hedgehogs (Hhs) and their receptors are involved in organ development as well as in tumorigenesis observed in basal cell carcinoma. Among Hhs, Desert hedgehog secreted from Schwann cells mediates the formation of peripheral nerve sheaths. However, there has been no study on the role of Hhs and their receptors in tumorigenesis of neurofibromas in neurofibromatosis type 1 (NF1).To clarify the expression and localization of Hhs and their receptors in neurofibromas of NF1 patients.Expression of Hhs and their receptors was studied by immunohistochemistry using neurofibromas from NF1 patients and control normal skin samples.In neurofibromas, CD57-positive tumour cells with delicate elongated processes were positive for the receptor PTCH2. Perineurial cells of involved nerves within neurofibromas as well as those of normal cutaneous nerves expressed Indian hedgehog and Sonic hedgehog. Schwann cells of normal cutaneous nerves were positive for PTCH2.Our study suggests that a paracrine Hh signalling pathway may be involved in tumorigenesis of neurofibromas in NF1.
Estradiol Alters Cell Growth in Nonmalignant Colonocytes and Reduces the Formation of Preneoplastic Lesions in the Colon
Authors: Charles C. Weige, Kimberly F. Allred, Clinton D. Allred
Journal: Cancer Research (2009)

Numerous clinical and animal studies show that hormone replacement therapy reduces the risk of colon tumor formation. However, the majority of experiments have shown that estradiol (E(2)) does not inhibit the growth of malignantly transformed colon epithelia. As such, the presented studies focused on evaluating the effects of E(2) in noncancerous colonocytes. E(2) treatments (0-10 nmol/L) reduced cell growth and increased apoptotic activity in young adult mouse colonocytes (YAMC), a nonmalignant cell line, in a dose-responsive manner. These effects were lost in the YAMC-Ras cells, an isogenic cell line with a single malignant transformation. Cotreatment with an estrogen receptor (ER) antagonist inhibited the physiologic effects of E(2) in YAMC cells, suggesting that the response is ER mediated. To further study the effect of E(2) on colonic epithelia, we evaluated the development of preneoplastic lesions in ovariectomized wild-type (WT) and ERbeta knockout (ERbetaKO) mice treated with either vehicle or E(2). WT E(2)-treated animals exhibited significantly fewer aberrant crypt foci and increased apoptotic activity in colonic epithelia when compared with WT control mice or ERbetaKO animals receiving either treatment. For the first time, we showed that E(2) alters the growth of nontransformed colonocytes in vitro and that, through an ERbeta-mediated mechanism, E(2) influences the physiology of noncancerous colonocytes, resulting in fewer preneoplastic lesions. Collectively, these data show that the protective actions of E(2) occur primarily during the initiation/promotion stages of disease development and identify the hormone as an important chemoprotective agent.
Eight Rights of Safe Electronic Health Record Use
Authors: Dean F. Sittig
Journal: JAMA (2009)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
THE IMPACT OF GENETIC POLYMORPHISM T45G ON ADIPONECTIN GENE ON THE EXPRESSION OF ADIPOKINES IN ARTERIAL HYPERTENSION
Authors: Alexis S. Antonopoulos, Dimitris Tousoulis, Charalambos Antoniades, Antigoni Miliou, Nikolaos Koumallos, George Hatzis, Michael Dimosthenous, Constantinos Bakogiannis, Costas Tsioufis, Kostas Toutouzas
Journal: Journal of the American College of Cardiology (2010)
Exposure measurement error in time-series studies of air pollution: concepts and consequences.
Authors: S L Zeger, D Thomas, F Dominici, J M Samet, J Schwartz, D Dockery, A Cohen
Journal: Environmental Health Perspectives (2000)

Misclassification of exposure is a well-recognized inherent limitation of epidemiologic studies of disease and the environment. For many agents of interest, exposures take place over time and in multiple locations; accurately estimating the relevant exposures for an individual participant in epidemiologic studies is often daunting, particularly within the limits set by feasibility, participant burden, and cost. Researchers have taken steps to deal with the consequences of measurement error by limiting the degree of error through a study's design, estimating the degree of error using a nested validation study, and by adjusting for measurement error in statistical analyses. In this paper, we address measurement error in observational studies of air pollution and health. Because measurement error may have substantial implications for interpreting epidemiologic studies on air pollution, particularly the time-series analyses, we developed a systematic conceptual formulation of the problem of measurement error in epidemiologic studies of air pollution and then considered the consequences within this formulation. When possible, we used available relevant data to make simple estimates of measurement error effects. This paper provides an overview of measurement errors in linear regression, distinguishing two extremes of a continuum-Berkson from classical type errors, and the univariate from the multivariate predictor case. We then propose one conceptual framework for the evaluation of measurement errors in the log-linear regression used for time-series studies of particulate air pollution and mortality and identify three main components of error. We present new simple analyses of data on exposures of particulate matter < 10 microm in aerodynamic diameter from the Particle Total Exposure Assessment Methodology Study. Finally, we summarize open questions regarding measurement error and suggest the kind of additional data necessary to address them.
A British Medical Association Lecture on HEART ATTACKS
Authors: C. F. Coombs
Journal: BMJ (1928)

THE diversitv of phenomena attributed to cardiac origin will be apparent from the following list of diagnoses collected: duiring the-past three months ini cases labelled by the-patients themselves as heart attacks.First cdmes the -groiup of troubles not actually connected with the heart at all-gall-stones, epilepsy, aural vertigo, narco- lepsy.Secondly, there are disturbances of the heart without evidence of organic disease.Of tlhese-there are two chief varieties-premature *beats and -ex-tracardiac arrh-ythmiia, the latter manifesting itself oftenest as speeding, but sometimes as slowing, of the heart.Last-of all come the cardiac attacks proper, the symptoms of which are caused by organic disease of the heart.A-ngina pectoris, cardiac inifaretion, acute oedema of the lungs, and cardiac asthma all 'come within this group; so also-do mest cases of auricular flutter, so far as mv own experience has gone.The predominant symptoms may be roughly divided into twoo classes-the caidiac aind--the peripheral.The patient suspects his heart of being the-cause of his attaclks, either because he feels 'somlethingam-iss in the region in which he believes this organ to lie, or because of symptoms else- wlhere which common report has taught him to regard as cardiac in origin.Subjectivelv considered, these attacks may be discussed under four lheadings, according to the predominant symptoms.
Tinker, Leader, Surgeon, Guide
Authors: Robert E. McAfee
Journal: JAMA (1997)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
594 FACTORS ASSOCIATED WITH THE EXPRESSION OF THE SIGNAL TRANSDUCERS AND ACTIVATORS OF TRANSCRIPTION (STAT) IN CHRONIC HEPATITIS C
Authors: H. Miyaaki, T. Ichikawa, K. Nakao, S. Takeshita, H. Shibata, E. Ozawa, M. Akiyama, S. Miuma, M. Fujimoto, K. Eguchi
Journal: Journal of Hepatology (2008)
Epidermolysis Bullosa Oropharyngeal Severity (EBOS) score: A multicenter development and reliability assessment
Authors: Giulio Fortuna, Nita Chainani-Wu, Francina Lozada-Nur, Massimo Aria, Rodrigo Cepeda-Valdes, Annamaria Pollio, M. Peter Marinkovich, Adriana E. Martinez-Salazar, Michele D. Mignogna, Anna L. Bruckner, Julio Cesar Salas-Alanís
Journal: Journal of the American Academy of Dermatology (2012)
Abdominal Sacrocolpopexy with Burch Colposuspension to Reduce Urinary Stress Incontinence
Authors: Linda Brubaker, Geoffrey W. Cundiff, Paul Fine, Ingrid Nygaard, Holly E. Richter, Anthony G. Visco, Halina Zyczynski, Morton B. Brown, Anne M. Weber
Journal: New England Journal of Medicine (2006)

We designed this trial to assess whether the addition of standardized Burch colposuspension to abdominal sacrocolpopexy for the treatment of pelvic-organ prolapse decreases postoperative stress urinary incontinence in women without preoperative symptoms of stress incontinence.Women who did not report symptoms of stress incontinence and who chose to undergo sacrocolpopexy to treat prolapse were randomly assigned to concomitant Burch colposuspension or to no Burch colposuspension (control) and were evaluated in a blinded fashion three months after the surgery. The primary outcomes included measures of stress incontinence (symptoms, stress testing, or treatment) and measures of urge symptoms. Enrollment was stopped after the first interim analysis because of a significantly lower frequency of stress incontinence in the group that underwent the Burch colposuspension.Of 322 women who underwent randomization, 157 were assigned to Burch colposuspension and 165 to the control group. Three months after surgery, 33.6 percent of the women in the Burch group and 57.4 percent of the controls met one or more of the criteria for stress incontinence (P<0.001) [Corrected]. There was no significant difference between the Burch group and the control group in the frequency of urge incontinence (32.7 percent vs. 38.4 percent, P=0.48). After surgery, women in the control group were more likely to report bothersome symptoms of stress incontinence than those in the Burch group who had stress incontinence (24.5 percent vs. 6.1 percent, P<0.001).In women without stress incontinence who are undergoing abdominal sacrocolpopexy for prolapse, Burch colposuspension significantly reduced postoperative symptoms of stress incontinence without increasing other lower urinary tract symptoms.