tbuckley/cabot-search huggingface dataset:
Infectious Mononucleosis and Leukemia
Authors: Stuart M. Copperman
Journal: JAMA (1982)

To the Editor.—  Regarding the association of infectious mononucleosis and acute leukemia (1981;246:1783), readers might be interested in this case report of a girl in whom a bone marrow examination was done during the onset of a severe case of infectious mononucleosis one year before acute myeloblastic leukemia developed.  Report of a Case.—  A 14-year-old girl was seen for an acute onset of a febrile illness associated with severe fatigue. On examination, she was noted to be extremely pale. She had exudative tonsillitis, generalized glandular enlargement, and a spleen that was palpable 3 cm below the costal margin. She experienced severe epistaxis that day and had right periorbital ecchymosis. The hemoglobin level was 10 g/dL. The hemoglobin level determined two weeks previously during a routine annual examination was 13 g/dL. A bone marrow examination was performed and revealed typical findings of infectious mononucleosis.  The patient had an uneventful recovery during
A Prospective Study of Benign Breast Disease and the Risk of Breast Cancer
Authors: Stephanie J. London
Journal: JAMA (1992)

<h3>Objective.</h3> —To examine the relation between proliferative benign breast disease with and without atypical hyperplasia and the subsequent risk of breast cancer. <h3>Design.</h3> —Case-control study nested within a prospective cohort study. Median follow-up after breast biopsy was 8 years (25th to 75th percentile, 5 to 14 years). <h3>Participants.</h3> —Selected from a prospective cohort of 121 700 US registered nurses followed up from 1976 to 1986. Cases were women with breast cancer who had a prior biopsy for benign breast disease. Controls were randomly selected and matched on year of biopsy and year of birth from among women in the cohort who had a benign breast biopsy but who did not develop breast cancer. Included in the analysis were 121 cases and 488 controls. <h3>Main Outcome Measure.</h3> —Development of breast cancer. <h3>Results.</h3> —Slides from the first benign breast biopsy were reviewed by two breast pathologists blinded to the outcome. The multiply adjusted relative risks (RRs) for breast cancer, relative to women with no proliferative disease, were 1.6 for proliferative disease without atypia (95% confidence interval [Cl], 1.0 to 2.5) and 3.7 for atypical hyperplasia (95% Cl, 2.1 to 6.8). Breast cancer risk was more strongly associated with atypical hyperplasia among premenopausal women (RR = 5.9; 95% Cl, 2.9 to 13.2) than postmenopausal women (RR = 2.3; 95% Cl, 0.9 to 5.9), but the association of breast cancer risk with proliferative disease without atypia did not differ across menopausal status. <h3>Conclusion.</h3> —These results confirm the marked increase in breast cancer risk among women with atypical hyperplasia, particularly in premenopausal women, and suggest that these women should be encouraged to undergo frequent breast cancer screening. (<i>JAMA</i>. 1992;267:941-944)
P30 Feasibility of a New Out-Patient Breathlessness Support Service
Authors: CC Reilly, C Bausewein, C Jolley, J Kelly, H Bellas, P Mandan, C Panell, S De Wolf-Linder, E Brink, C De Biase, J Moxham, I J Higginson
Journal: Thorax (2012)

<h3>Background</h3> Breathlessness is a common and devastating symptom affecting many patients with advanced malignant and non-malignant disease. Management comprises non-pharmacological and pharmacological interventions best delivered by a multidisciplinary group. <h3>Aim</h3> To describe the feasibility of a study testing a newly established Breathlessness Support Service (BSS) at King’s College Hospital, London. <h3>Methods</h3> An innovative BSS with palliative care and respiratory medicine (consultant, nurse, physiotherapy, occupational therapy, and social work) input is offered since October 2010 to patients with refractory breathlessness due to advanced malignant and non-malignant disease. Patients are seen twice in the clinic and offered a home visit by physiotherapy and occupational therapy. The new service is evaluated in a phase 3 fast track randomised controlled trial (RCT) comparing immediate or delayed (after 6 weeks) access to BSS. <h3>Results</h3> Between October 2010 and June 2012, 191 patients have been referred to our study, of which 88 patients have consented to partake in the study (48/88 male; median age 68 y (range 40–84 y); 62/88 carer present; COPD 45, Cancer 17, ILD 18, heart failure 6, Asthma 1, other 1). Of these 88 patients, 60 patients have completed the study (primary endpoint at 6 weeks), with 11 patients awaiting their 6 week assessment. The current attrition rate for the primary endpoint of the study (6 weeks) is approximately 19%, much less than 40% we originally anticipated. 40 have completed the 12 week follow up home visit (secondary endpoint), with 12 patients awaiting their 12 week assessment. The current attrition rate for the secondary end point is 34%, reflective of the complexity of retaining palliative care patients in a RCT. The BSS is well received by patients. Main organisational problems relate to transport to the BSS and patients being unwell to attend the second clinic visit. <h3>Conclusion</h3> Referral to the study is similar to what we expected with the number of patients consenting (46%) to partake similar to that reported in the pulmonary rehabilitation literature. Once in the trial, attrition is low. Overall, the BSS seems to be feasible.
Periodontal manifestations of collagen vascular disorders
Authors: Theresa S. Gonzales, Gary C. Coleman
Journal: Periodontology 2000 (1999)

Chronic degeneration of connective tissue components can be produced by a variety of autoimmune mechanisms. The designations connective tissue disease and collagen-vascular disease are commonly used to describe such conditions when a patient exhibits chronic, immune-mediated deterioration of connective tissue structures in a systemic distribution. Recognized conditions that fit this definition include rheumatoid arthritis, lupus erythematosus, progressive systemic sclerosis, CREST syndrome, and mixed connective tissue disease. Several characteristic oral manifestations of these conditions are recognized. Xerostomia associated with any of these conditions in addition to dryness of the eyes is the definition of secondary Sjögren's syndrome. Fibrosis of facial skin and the resulting limited jaw opening are diagnostic features of progressive systemic sclerosis. Several periodontal manifestations are associated with these connective tissue disorders. Dramatic periodontal ligament space widening that is associated with some cases of progressive systemic sclerosis has been appreciated for more than five decades. However, it has been more recently reported that the majority of progressive systemic sclerosis patients exhibit at least subtle generalized periodontal ligament widening when intraoral radiographs are carefully evaluated. This finding is, however, of limited periodontal significance because the teeth are typically not mobile. Comparisons of periodontitis indices such as pocket depth between healthy subjects and patients with progressive systemic sclerosis do not reveal significant differences (21). In addition, recent evidence suggests a tendency for more severe or progressive manifestations of periodontitis as a consequence of xerostomia that may result from these diseases.
Clinical Approach to Infection in the Compromised Host
Authors: John Z. Montgomerie
Journal: JAMA (1982)

This book covers the important area of infection in the immunocompromised host in a clinical approach to the problem, and it is a major step forward. The subject matter is broad and ill defined, but the editors have selected well. The main emphasis has been placed on infections associated with immunosuppressive drugs, oncology, leukemia, and renal and marrow transplantation. Infections in the immunocompromised host are rapidly developing areas, and the authors have not avoided controversy. There was the obvious conflict in a text of this type as to whether to organize chapters by organ system, infectious disease, or type of compromise, and some reduplication is expected. There is, however, very little, and the chapters are well written, well referenced, and up to date. In addition to infectious disease specialists, a wide range of physicians are interested in the infections of the immunocompromised host, and this book will be widely read.
Fits and Faints
Authors: Gerald F. Tremblay
Journal: JAMA (1991)

A toddler bumps her head, becomes pale, and silently slumps to the floor. When her mother picks her up, the child stiffens, then jerks a few times. A retarded teenaged boy with the diagnosis of refractory epilepsy comes to the emergency department after another one of his "seizures." In the hospital the doctor sees him hold his breath, collapse, and have a brief convulsion. A young woman complains of strange feelings that are occasionally followed by a brief convulsion. Careful interviewing reveals the attacks are often triggered by a startling event, such as a ringing alarm clock. The above vignettes illustrate problems that fall loosely into the category of "seizures." Since the word implies epileptic seizure to American physicians, a less misleading term would be "spells." None of the above people had epilepsy as the primary cause of their spells. The first had pallid infantile syncope, the second self-induced anoxic
Gene transfer targeting interstitial fibroblasts by the artificial viral envelope-type hemagglutinating virus of Japan liposome method
Authors: Michiko Tsujie, Yoshitaka Isaka, Yutaka Ando, Yoshitaka Akagi, Yasufumi Kaneda, Naohiko Ueda, Enyu Imai, Masatsugu Hori
Journal: Kidney International (2000)
Robert Allardyce Main
Authors: M I White
Journal: BMJ (2003)

Former consultant dermatologist Aberdeen (b 1926; q St Andrews 1949; FRCP), died from Parkinson's disease on 4 April 2003.​2003.




Figure 1




After house jobs and national service in the Royal Air Force, Robert worked in dermatology in Dundee. His lifelong interest in pigmentary disorders developed when he spent a year at Boston Medical School, United States. He then continued work on melanophores at the Welsh National School of Medicine. He gained further clinical experience in Canada and Dundee before his appointment as consultant in 1962. In 1975 he was appointed honorary clinical reader in dermatology, University of Aberdeen. He leaves a wife, Kay; two children; and two grandchildren.
INTERACTION BETWEEN OLEATE AND THE LIPOPROTEINS OF HUMAN SERUM
Authors: Robert S. Gordon
Journal: Journal of Clinical Investigation (1955)

Since the pioneer observations of Hahn (1), who noted that heparin injection caused the disappearance of visible lipemia, and of Anderson and Fawcett (2), who showed that this effect was due not to heparin itself but to a   which appeared in plasma after heparin injection, there has been considerable interest in the biochemical and physiological aspects of this phenomenon, often called the  reaction. A variety of effects over and above the mere disappearance of turbidity has been attributed to clearing factor action. Evidence presented by several independent groups of investigators (3-7) would appear to establish the fact that in the presence of clearing factor, triglycerides are hydrolyzed in in vitro systems with the liberation of glycerol and free fatty acids. This conclusion is further confirmed by a considerable amount of data from this laboratory which are, as yet, unpublished (8). The lipolytic reaction may be broadly formulated
Comparison between ibuterol hydrochloride and terbutaline in asthma.
Authors: B Arner, P O Magnusson
Journal: BMJ (1976)

The bronchodilating effect, circulatory effects, and subjective side effects of ibuterol hydrochloride, the di-isobutyric acid ester of terbutaline, at two dose levels (2 and 4 mg) were compared with those of 5 mg terbutaline sulphate in a double-blind cross-over study on 12 patients with asthma. Both drugs were given by mouth. The 2-mg dose of ibuterol had the same bronchodilating effect during the first three hours as 5 mg terbutaline. The 4-mg dose, however, produced a significantly greater increase in the peak expiratory flow rate between the 30th and 120th minutes than terbutaline. No significant changes in heart rate or pulse amplitude were noted, and there was no difference in the incidence of subjective side effects between ibuterol at either dose level and terbutaline.
Gas gangrene after burns.
Authors: H H Eastcott
Journal: BMJ (1979)

When he finished reading the paper he tore it into small pieces and started throwing the pieces out of the window.The second man said, "What are you doing that for ?" and the first man answered, "I do it to keep down the elephants."Whereupon the second man said, "There aren't any elephants" and the first replied, "Effective, isn't it ?"
The Last Word on Using Grids
Authors: Andrew B. Weinberger
Journal: Annals of Internal Medicine (1994)

Letters15 February 1994The Last Word on Using GridsAndrew B. Weinberger, MDAndrew B. Weinberger, MDSt. Elizabeth Hospital; Elizabeth, NJ 07207Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-120-4-199402150-00027 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:I was delighted with the letter [1] concerning “grids” used to chart laboratory results, until I reached the last two sentences, in which a uniform grid style is proposed. These notations are often indecipherable or confusing. Because no labels exist, grids require much more time to interpret than does a simple listing of values. People use the grids in their own ways, resulting in numbers that have no intrinsic meaning to many who use the chart. These markings will make even less sense in the future.I believe that Spaulding and Silverblatt are correct in their analysis ...REFERENCE1. Spaulding A, Silverblatt FJ. Using grids to document laboratory results (Letter). Ann Intern Med. 1993; 119:863. Google Scholar Author, Article, and Disclosure InformationAffiliations: St. Elizabeth Hospital; Elizabeth, NJ 07207 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 15 February 1994Volume 120, Issue 4Page: 347KeywordsChartsForecastingResearch laboratories Issue Published: 15 February 1994 Copyright & PermissionsCopyright © 1994 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Multicentre research ethics committees: has the cure been worse than the disease?
Authors: K G M M Alberti
Journal: BMJ (2000)

Papers pp 1179, 1182, 1183 Personal view p 1217 

I first wrote about the byzantine labyrinth that surrounded obtaining ethics committees' approval for multicentre studies in England in 1995, as well as mentioning other unsatisfactory aspects of local research ethics committees.1 At that time a working party of the chief medical officer suggested the establishment of multicentre research ethics committees on a regional basis to take care of multicentre studies. These were established in 1997.2 So is it now simpler to obtain approval for multicentre studies? Are decisions reached more speedily? Are local research ethics committees restricting their comments on multicentre studies to local problems?Or has yet another layer of bureaucracy been added, making the process even more labyrinthine?

In the past two years frustrated research workers have regularly told me that the new system is a disaster. Early feedback suggested that local research ethics committees were finding their subordinate role difficult. These committees have always jealously guarded their independence. The early problems led to further guidance from the Department of Health and NHS Executive on the precise responsibility …
Effect of Chlorothiazide on Response of Renal Vascular Bed to Vasoactive Substances
Authors: Jay Y. Gillenwater, Jerry B. Scott, Edward D. Frohlich
Journal: Circulation Research (1962)

In the anesthetized dog, administration of an isosmotic solution of chlorothiazide into the renal artery failed to affect renal vascular resistance but did acutely attenuate the constriction produced by intra-arterial injection of l -epinephrine, levarterenol, and Val-5-angiotensin II and potentiated the dilation produced by intra-arterial injection of MgCl 2 .
Role of interleukin 2, interleukin 4, and alpha, beta, and gamma interferon in stimulating macrophage antibody-dependent tumoricidal activity.
Authors: P Ralph, I Nakoinz, D Rennick
Journal: The Journal of Experimental Medicine (1988)

Pretreatment of murine peritoneal exudate macrophages with 1-5 U/ml rIFN-gamma or rIL-2, or higher concentrations of IFN-alpha or IFN-beta greatly stimulated ADCC to Rl lymphoma targets. The assay was direct counting of viable target cells after 9 and 24 h using an E/T ratio of 5:1. 2d of pretreatment was optimal for enhancing ADCC. rIL-4 was inactive and IL-4-depleted Con A-induced spleen lymphokine retained its ADCC-stimulating activity. Antibody to IFN-gamma blocked the ADCC-promoting effect of the lymphokine, suggesting a major role for this factor.
Carbon Monoxide and Cardiovascular Disease
Authors: Edward M. Dwyer, Gerard M. Turino
Journal: New England Journal of Medicine (1989)

Lethal exposure to carbon monoxide occurs all too frequently in fires, industrial accidents, and suicides. During the past two decades, however, evidence has been mounting that exposure to small amounts of carbon monoxide in the atmosphere has physiologic and clinical consequences, particularly for the cardiovascular system.The paper by Allred et al.1 in this issue of the Journal demonstrates some limitation of exercise capacity in patients with known coronary artery disease who were exposed to carbon monoxide, as reflected by shortening of the length of time to anginal pain and ST-segment depression. This well-planned multicenter study confirms and extends previously . . .
Insulin Sensitivity and Insulin Secretion Determined by Homeostasis Model Assessment and Risk of Diabetes in a Multiethnic Cohort of Women: the Women’s Health Initiative Observational Study
Authors: Edward J. Boyko, Dianna Magliano, Jonathan E. Shaw
Journal: Diabetes Care (2007)

We read with interest the article (1) on the risk of incident diabetes in the Women’s Health Initiative Observational Study (WHI-OS) in relation to homeostasis model assessment (HOMA) of insulin resistance (HOMA-IR) and β-cell function (HOMA-B). In this letter, we raise a number of issues that we believe require further clarification.

The aim of Song et al.’s study was “to prospectively examine the relations of HOMA … with diabetes risk” (1). Why, then, are 766 women with a fasting glucose at baseline ≥126 mg/dl included in the analysis? Although these women were excluded from other analyses, it is unclear why they …
Gastric glomus tumor: report of one case and review
Authors: F. Orellana, C. Onetto, P. Balbontín, D. Videla, L. Manriquez, R. Plass, R. Araya, R. Sepúlveda, R. Saenz, H. Ríos
Journal: Endoscopy (2011)

A healthy 26-year-old woman presented with a year of intermittent epigastric pain but no other symptoms. Upper gastrointestinal endoscopy showed, on the anterior wall of the gastric body, a submucosal, elevated, well-defined lesion measuring 3 cm in diameter, with normal overlying mucosa ([Fig. 1]).
Characterization of left ventricular mechanical function during arrhythmias by two-dimensional echocardiography. II. Location of the site of onset of premature ventricular systoles
Authors: Marco A.R. Torres, Eliot Corday, Samuel Meerbaum, Tatsuo Sakamaki, Thomas Peter, Takahisa Uchiyama
Journal: Journal of the American College of Cardiology (1983)
Medical devices regulation needs to be overhauled, says cardiologist
Authors: J. Wise
Journal: BMJ (2011)

The standards of evidence required for licensing medical devices should be the same as for drugs, Peter Wilmshurst told a Royal College of Surgeons meeting this week.

Dr Wilmshurst, a consultant cardiologist at the Royal Shrewsbury Hospital, gave his personal perspective on the need for an overhaul of medical devices regulation after his defence of three defamation claims.

The US medical device company NMT Medical sued Dr Wilmshurst after he spoke of his concerns about the migraine intervention with STARFlex technology (MIST) trial, in which he was the principal cardiologist ( BMJ 2008;337:a2412, doi:10.1136/bmj.a2412). The defamation claims recently ended after almost four years when the company went into liquidation.

“I believe concerns about litigation have prevented some doctors from reporting adverse events,” Dr Wilmshurst told the meeting, called “New techniques and new technologies: ethics …
177 5′-Methylthioadenosine modulates the inflammatory response to bacterial lipopolysaccharide
Authors: H. Hevia, M. Varela-Rey, F.J. Corrales, C. Berasain, M.L. Martinez-Chantar, M.U. Latasa, S.C. Lu, J.M. Mato, E.R. Garcia-Trevijano, M.A. Avila
Journal: Journal of Hepatology (2004)
Is the size of the human corpus callosum influenced by sex hormones?
Authors: Elizabeth Hampson
Journal: Behavioral and Brain Sciences (1998)

Fitch &amp; Denenberg have shown that manipulations of ovarian and testicular hormones early in development can influence the adult size of the corpus callosum in the rat. The human corpus callosum is highly variable in size and shape, but data are only now beginning to emerge on whether sex steroids influence callosal differentiation in humans. I describe recent data from our own laboratory and suggest avenues for future research.
Guideline vs. practice in procollagen-3-aminopeptide monitoring
Authors: G. Parkins, G. Wylie
Journal: British Journal of Dermatology (2014)

Journal Article Guideline vs. practice in procollagen‐3‐aminopeptide monitoring Get access G. Parkins, G. Parkins Alan Lyell Centre for Dermatology Department of Dermatology Southern General Hospital 1345 Govan Road Glasgow G51 4TF U.K Search for other works by this author on: Oxford Academic Google Scholar G. Wylie G. Wylie Alan Lyell Centre for Dermatology Department of Dermatology Southern General Hospital 1345 Govan Road Glasgow G51 4TF U.K Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 171, Issue 6, 1 December 2014, Pages 1599–1600, https://doi.org/10.1111/bjd.13184 Published: 01 December 2014
Group B streptococci in the female genital tract.
Authors: R G Finch, G L French, I Phillips
Journal: BMJ (1976)

Vaginal carriage rates of group B streptococci among 250 women attending a clinic for sexually transmitted diseases, 123 attending family planning clinics, and 110 in labour wages were 36.0%, 17-1% and 6.4% respectively. The presence of group B streptococci was not associated with a vaginal discharge or the use of oral contraceptives in the non-pregnant women, or with the isolation of Neisseria gonorrhoeae or Trichomonas vaginalis from the women attending the clinic for sexually transmitted diseases. Serotyping showed a predominance of types II and III in non-pregnant women and an overall incidence of non-typable strains of 14.8%. There was no relationship between serotype and antibacterial susceptibility.
Human cytomegalovirus-encoded UL33 and UL78 heteromerize with host CCR5 and CXCR4 impairing their HIV coreceptor activity
Authors: Kenjiro Tadagaki, Daniela Tudor, Florence Gbahou, Pia Tschische, Maria Waldhoer, Morgane Bomsel, Ralf Jockers, Maud Kamal
Journal: Blood (2012)