tbuckley/cabot-search huggingface dataset:
UV-induced pyrimidine dimers and rosacea
Authors: Enrico Nunzi, Alfredo Rebora, Jan J. Cornelis, Rudy H. Cormane
Journal: British Journal of Dermatology (1981)

Journal Article UV‐induced pyrimidine dimers and rosacea Get access Enrico Nunzi, Enrico Nunzi Clinica Dermatologica II, Universita di Genova, Genova, Italy Search for other works by this author on: Oxford Academic Google Scholar Alfredo Rebora, Alfredo Rebora Clinica Dermatologica II, Universita di Genova, Genova, Italy Search for other works by this author on: Oxford Academic Google Scholar Jan J. Cornelis, Jan J. Cornelis Departement de Biologie Moleculaire, Université Libre de Bruxelles, Rhode St Genèse, Belgium Search for other works by this author on: Oxford Academic Google Scholar Rudy H. Cormane Rudy H. Cormane Department of Dermatology, University of Amsterdam, Amsterdam, The Netherlands Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 104, Issue 6, 1 June 1981, Page 711, https://doi.org/10.1111/j.1365-2133.1981.tb00761.x Published: 01 June 1981
Cancer Centers Survive Latest California Earthquake
Authors: T. Parkins
Journal: JNCI Journal of the National Cancer Institute (1994)

Journal Article Cancer Centers Survive Latest California Earthquake Get access Troy Parkins Troy Parkins Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 86, Issue 4, 16 February 1994, Pages 263–264, https://doi.org/10.1093/jnci/86.4.263 Published: 16 February 1994
Double-blind controlled crossover high-dose study of Azaribine in psoriasis*
Authors: WILLIAM A. CRUTCHER, SAMUEL L. MOSCHELLA
Journal: British Journal of Dermatology (1975)

Azaribine used in high doses of 200 mg/kg a day is an effective agent in inducing temporary remissions in patients with severe psoriasis but potentially serious neurotoxicity may occur. Therapy should be initiated at lower doses of 125 mg/kg a day and advanced carefully only if clinical response does not ensue at the lower level.
AN INTESTINAL SUTURE.
Authors: RAYMOND CUSTER TURCK
Journal: JAMA (1900)

The "ideal" intestinal suture is one which will combine simplicity, strength, rapidity of insertion, and absolute insurance from leakage. Without going exhaustively into the relative merits or demerits of the various sutures now in vogue, I would like, however, to mention a few points regarding the one probably most widely in use at present, i. e., the Halsted suture. In Diagram 1 are shown Halsted sutures inserted, but not tied. When the knot is tied the serous surfaces of the bowel are approximated, and cut edges inverted, but, not only do the sutures draw longitudinally on being tied, and thus draw the wound together, but at the same time they draw laterally, as indicated by the arrow-heads. This latitudinal tension tends to draw the sides of the sutures together, but at the same time draws the sutures away, each from the other, leaving weak points as indicated in Diagram 2.
Arsenic and Visceral Cancer
Authors: B. F. Russell
Journal: BMJ (1963)

v-ning years, and a more realistic ap- praisal of the drug's toxicity might be that of H. Beckman,8 who stated of meprobamate, " Since this drug has been used in enormous quantities around the world, being sold over the counter with- out prescription in some countries, it must be considered among the least toxic of agents because so few really serious reac- tions have been reported."-Iam, etc.,
Accidental Drowning of Toddlers in Buckets-Reply
Authors: Mary I. Jumbelic
Journal: JAMA (1990)

<h3>In Reply.—</h3> We agree with Dr Helmuth's astute observation that livor mortis is present on the back of the infant in the photograph in our article. Lividity was not seen at the time the infant was found in the bucket but developed after the body was placed in a supine position overnight. The photograph was taken the day after death to demonstrate the circumstances at the time of the infant's death. It also illustrates how these 5-gallon containers do not tip over with the infant inside, even when empty. As forensic pathologists, we are always suspicious of deaths in children, even in the context of apparent accidents. We investigate the circumstances of death and perform thorough autopsies. All of the infants in our study died of accidental drowning, with no evidence of homicide. We appreciate the comments of Dr Hyma and agree that these 5-gallon containers represent an unsuspected
BETA-ARRESTINS REGULATE SIGNALING BY BONE MORPHOGENETIC PROTEIN TYPE II RECEPTOR IN PULMONARY ARTERIAL HYPERTENSION
Authors: Sudarshan Rajagopal, Jeff Kovacs, Cristian Badea, G. Allan Johnson, Howard A. Rockman, Claude A. Piantadosi, Robert J. Lefkowitz
Journal: Journal of the American College of Cardiology (2011)
Detection of apoptotic caspase activation in sera from patients with chronic HCV infection is associated with fibrotic liver injury
Authors: Heike Bantel, Andreas Lügering, Jan Heidemann, Xandra Volkmann, Christopher Poremba, Christian P. Strassburg, Michael Peter Manns, Klaus Schulze-Osthoff
Journal: Hepatology (2004)

Chronic hepatitis C virus (HCV) infection is characterized by inflammatory liver damage and is associated with a high risk of development of cirrhosis and hepatocellular carcinoma. Although histological examination of liver biopsies is currently the gold standard for the detection of early liver damage, there is a strong need for better noninvasive methods. We recently demonstrated that the proapoptotic activation of caspases is considerably enhanced in histological sections from HCV-infected liver tissue, suggesting an important role of apoptosis in liver damage. Here, we investigated whether caspase activation is detectable also in sera from patients with chronic HCV infection. Using a novel enzyme-linked immunosorbent assay that selectively recognizes a proteolytic neoepitope of the caspase substrate cytokeratin-18, we demonstrate that caspase activity is markedly increased in the sera of HCV patients. Interestingly, while 27% of patients with chronic HCV infection showed normal aminotransferase levels despite inflammatory and fibrotic liver damage, more than 50% of those patients exhibited already elevated serum caspase activity. Moreover, 30% of patients with normal aminotransferase but elevated caspase activity revealed higher stages of fibrosis. In conclusion , compared with conventional surrogate markers such as aminotransferases, detection of caspase activity in serum might be a more sensitive method of detecting early liver injury. Thus, measurement of caspase activity might provide a novel diagnostic tool, especially for patients with normal aminotransferases but otherwise undiagnosed histologically active hepatitis and progressive fibrosis. (Hepatology 2004;40:1078-1087.)
New government is to introduce universal primary care for Ireland
Authors: M. Houston
Journal: BMJ (2011)

In a substantial change to health policy, a newly elected Irish government has said it will implement a universal single tier health service by 2016. It said the move will guarantee access to medical care based on clinical need rather than an ability to pay.

Currently some 40% of the population receive free GP care with the remainder paying privately to see a doctor and for prescription medicines. Although free hospital care is available to all, in practice lengthening waiting times meant many people took out health insurance, which bought them quicker access to private hospital investigations and procedures. …
Aids for Determining Magnitude and Direction of Electric Axes of the Electrocardiogram
Authors: CHARLES E. JACKSON, TRAVIS WINSOR
Journal: Circulation (1950)

Tables are presented which serve to facilitate the determination of magnitudes and directions of the electrical axes of various waves and segments of the electrocardiogram (P, QRS, RS-T, T and G). The tables may be used with the standard or unipolar limb leads. Normal values for the magnitudes and directions of certain vectors are presented.
Cross-tolerance: A Pathway for Inducing Tolerance to Peripheral Tissue Antigens
Authors: William R. Heath, Christian Kurts, Jacques F.A.P. Miller, Francis R. Carbone
Journal: The Journal of Experimental Medicine (1998)

Tlymphocytes develop within the thymus, where they are positively selected for self-restriction and purged of cells exhibiting strong reactivity to self-antigens presented within this microenvironment. Mature lymphocytes then enter the peripheral lymphoid pool, where they recirculate between the
Treating Sternal Wound Infections After Cardiac Surgery With an Implantable Gentamicin-Collagen Sponge
Authors: Tim Corn
Journal: JAMA (2010)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Post-Partum Psychosis: Which Women Are at Highest Risk?
Authors: Phillipa J Hay
Journal: PLoS Medicine (2009)

A range of psychological disorders occur in women in the post-partum period. These include “the blues”, which occurs in the first days after birth and which is very common and self-limiting; severe psychoses often associated with mania or bipolar illness, occurring in the first weeks after birth [1]; and mild to moderate depression, occurring weeks to months after birth.
False-Positive Radionuclide Hepatobiliary Imaging Following Cystic Duct Stone Removal
Authors: RONALD J. ZAGORIA, ROBERT J. COWAN, RAYMOND B. DYER, MARCOS HERRERA
Journal: Clinical Nuclear Medicine (1989)

The authors report a case in which a radionuclide hepatobiliary image was falsely indicative of cystic duct obstruction in a patient with an Indwelling cholecystostomy tube and an externalized gallbladder-duodenal stent. Cystic duct patency was demonstrated radiographlcally shortiy before and after the radlonuclide study. The authors recommend that cystic duct obstruction indicated by a radionuclide hepaloblliary image be confirmed by another means if a cholecystostomy tube is present, or If the patient recently has undergone percutaneous gallbladder or cystic duct manipulations.
Pressure Ulcers in the Nursing Home
Authors: David M. Smith
Journal: Annals of Internal Medicine (1995)

Objective: To review the literature on the causes, epidemiology, prevention, and treatment of pressure ulcers in nursing homes and to summarize this information for clinicians caring for nursing home residents. Data Sources: A MEDLINE search of English-language articles published between 1980 and October 1994 using the terms decubitus ulcer and elderly. References from identified articles were also examined. Study Selection: Articles were excluded if the title indicated that patients were not nursing home residents (unless data from nursing homes were limited or unavailable), that patients were not elderly, or that the ulcers were related to peripheral vascular disease or neuropathy. Data Extraction: Selected studies either contained original data or were meta-analyses. Prevalence studies were required to have an identifiable denominator; risk factor and incidence studies were required to have an identifiable cohort and a specified duration of follow-up. Preference was given to risk factors identified through multivariate analyses. Studies of preventive and therapeutic interventions were required to have an identifiable control group; preference was given to randomized, controlled trials. Data Synthesis: Seventeen percent to 35% of patients have pressure ulcers at the time of admission to a nursing home, and the prevalence of pressure ulcers among nursing home residents ranges from 7% to 23%. Among high-risk patients, the incidence of pressure ulcers is estimated to be 14/1000 patient-days. Residents at higher risk for developing ulcers are those who have limited ability to reposition themselves, can-not sense the need to reposition, have fecal incontinence, or cannot feed themselves. Occlusive dressings are as effective and less costly than traditional wet-to-dry saline dressings for treating earlier stages of pressure ulcers. There is no consensus on the use of specialized beds in the nursing home for promoting the healing of advanced-stage ulcers or for reducing the incidence of ulcers in high-risk patients. Specific interventions should not detract from careful, total assessment and management of the patient. Conclusions: Pressure ulcers in the nursing home are common problems associated with significant morbidity and mortality. Because resident characteristics can identify residents likely to develop ulcers, preventive measures can be implemented early. Therapy for advanced stages of pressure ulcers is expensive and prolonged. Involvement of the physician with the multidisciplinary nursing home team is essential for prevention and therapy.
Benign familial tremor treated with primidone.
Authors: M D O'Brien, A R Upton, P A Toseland
Journal: BMJ (1981)

Primidone given to a patient for epilepsy produced an unexpected reduction in benign familial tremor. Over the next eight years the drug was therefore tried in a prospective study of 20 other patients with benign familial tremor alone. Of these, six could not tolerate the drug because of vertigo and nausea but 12 obtained a good response, which in some cases was dramatic. Investigations in two patients suggested that the effect was mediated predominantly by derived phenylethylmalonamide, though primidone had some effect, since tremor recurred slightly on withdrawing the drug despite a constant or rising blood phenylethylmalonamide concentration. Primidone is highly effective in benign familial tremor. More patients with the condition are intolerant of the drug than are usually found with epilepsy.
Phase 2 prolongation, in the absence of instability and triangulation, antagonizes class III proarrhythmia
Authors: L Hondeghem
Journal: Cardiovascular Research (2001)

Objective: To evaluate whether prolongation of the plateau of the action potential duration, in the absence of instability and triangulation, can reverse the proarrhythmia elicited by a class III antiarrhythmic agent. Methods: The effects of almokalant, erythromycin and their combination, on cardiac electrophysiological parameters (action potential duration (APD), instability, triangulation and ectopics) were evaluated in isolated hearts from female albino rabbits. In this study, proarrhythmia was estimated quantitatively by number of ectopic beats. Results: Erythromycin lengthened the APD primarily by a prolongation of the plateau, while having only minor effects upon phase 3 repolarization. The prolongation did not induce much instability, triangulation or reverse use dependence and, as expected, erythromycin did not induce significant proarrhythmia. Almokalant also lengthened APD, but it did not lengthen the plateau; instead, it prolonged phase 3 repolarization. The prolongation markedly triangulated the action potential, elicited much instability and marked reverse use dependence. This combination of effects induced very marked proarrhythmia. When almokalant and erythromycin were combined, their effects upon APD appeared additive: both the plateau and the repolarization phase were prolonged. However, the larger prolongation of APD did not lead to more proarrhythmia; this suggests that a prolongation of APD is not proarrhythmic per se. On the contrary, proarrhythmia as a function of APD prolongation was reduced in the presence of erythromycin (P<0.05). Conclusion: Instability plus triangulation consistently lead to serious proarrhythmia especially when combined with reverse use dependence, but prolongation of APD in itself is not necessarily proarrhythmic. In fact, APD prolongation in the absence of instability and triangulation can be antiarrhythmic.
Re: Christan Walter, Bilal Al-Nawas, Knut A. Grötz, et al. Prevalence and Risk Factors of Bisphosphonate-Associated Osteonecrosis of the Jaw in Prostate Cancer Patients with Advanced Disease Treated with Zoledronate. Eur Urol 2008;54:1066–72
Authors: Alfredo Berruti, Cinzia Ortega, Vittorio Fusco
Journal: European Urology (2008)
Association of transplant center and physician factors on mortality after hematopoietic stem cell transplantation in the United States
Authors: Fausto R. Loberiza, Mei-Jie Zhang, Stephanie J. Lee, John P. Klein, Charles F. LeMaistre, Derek S. Serna, Mary Eapen, Christopher N. Bredeson, Mary M. Horowitz, J. Douglas Rizzo
Journal: Blood (2004)
'Molecular level' view gives immune system clues
Authors: Charles Marwick
Journal: JAMA (1985)

As investigators, seeking clues to the causes of the acquired immunodeficiency syndrome (AIDS), have delved ever deeper into arcane aspects of the immunopathology involved, many of them have been struck by an apparent paradox: How can there be such a selective defect in AIDS and yet at the same time be such a broad spectrum of heterogeneous abnormalities? Speaking at the International Conference on AIDS in Atlanta, the head of a group of pioneer investigators into the immunology of AIDS, Anthony S. Fauci, MD, of the National Institutes of Health, Bethesda, Md, posed this question to his audience. In the process of answering it, he provided a look at some new findings on the abnormal functioning of the immune system in AIDS. Fauci is director of the National Institute of Allergy and Infectious Diseases. Despite his administrative responsibilities, which he assumed last November, Fauci spends a considerable portion of his
Cancer of the urogenital tract: bladder cancer. Combined radiotherapy and surgical treatment
Authors: W. F. Whitmore
Journal: JAMA (1969)

All reported experiences with the treatment of malignant bladder tumors indicate a sufficiently high incidence of therapeutic failure to justify, if not to demand, exploration of alternative methods offering a logical prospect of improvement. Since surgical treatment alone and radiation therapy alone have controlled some bladder cancers, it is empirically consistent to believe that the combination of these two modalities might prove more effective than either alone, and planned combinations of these two treatment methods provide one logical area for clinical trial. Clinical studies with combined irradiation and surgical intervention in the treatment of cancers of the head and neck, breast, lung, esophagus, and colon and rectum have suggested possible advantages of such combined therapy. Furthermore, occasional reports have suggested advantages of the use of interstitial irradiation or external irradiation combined with various forms of surgical excision for the treatment of selected patients with bladder cancer. Finally, laboratory studies of
Reiter's syndrome: long-term follow-up in relation to development of ankylosing spondylitis.
Authors: A E Good
Journal: Annals of the Rheumatic Diseases (1979)

This paper will be a brief revisit to an old study of Reiter's syndrome (RS) and ankylosing spondylitis (AS)133' 134 with an attempt to bring the series up to date.AS is defined here as back pain, persistent limi- tation of lumbrosacral mobility in all three planes, and grade 3 or 4 bilateral sacroiliitis (so-called New York criteria).Definite RS is defined as peripheral arthritis plus two or more of urethritis, muco- cutaneous involvement, and conjunctivitis or iritis.Probable RS is peripheral arthritis and one mani- festation, comprising urethritis in almost all cases.Normal 50 I
Evidence based policy for illicit drugs
Authors: E. Wood
Journal: BMJ (2010)

An ethical obligation for those working in the field of drug addiction

Systematic reviews have shown that methadone maintenance treatment significantly reduces heroin use compared with other treatments,1 and it also reduces HIV risk behaviour among injecting drug users.2 Not surprisingly, it is on the World Health Organization’s list of essential medicines.3 In the linked prospective cohort study (doi:10.1136/bmj.c3172) Kimber and colleagues describe the effect of opiate substitution treatment on mortality and time to long term injection cessation.4

The study, which is based on observational data from a single primary care facility in Edinburgh, found that longer duration on opiate substitution treatment (primarily methadone) was associated with reduced mortality, but that it was also associated with a lower likelihood of injection cessation. Although the association with improved survival might be expected on the basis of past research,1 2 the negative association between opiate substitution treatment and injection cessation is curious. Despite the limitations of the study, which Kimber and colleagues acknowledge, the study overall supports the already extensive evidence base for using methadone as a first line treatment for opioid …
Reduced hepatic stellate cell expression of kruppel-like factor 6 tumor suppressor isoforms amplifies fibrosis during acute and chronic rodent liver injury
Authors: Zahra Ghiassi-Nejad, Virginia Hernandez-Gea, Christopher Woodrell, Ursula E. Lang, Katja Dumic, Allison Kwong, Scott L. Friedman
Journal: Hepatology (2012)

Kruppel-like factor 6 (KLF6), a zinc finger transcription factor and tumor suppressor, is induced as an immediate-early gene during hepatic stellate cell (HSC) activation. The paradoxical induction of a tumor suppressor in HSCs during proliferation led us to explore the biology of wildtype KLF6 (KLF6(WT) ) and its antagonistic, alternatively spliced isoform KLF6(SV1) in cultured HSCs and animal models. The animal models generated include a global heterozygous KLF6 mouse (Klf6+/-), and transgenic mice expressing either hKLF6(WT) or hKLF6(SV1) under the control of the Collagen α2 (I) promoter to drive HSC-specific gene expression following injury. The rat Klf6 transcript has multiple splice forms that are homologous to those of the human KLF6 gene. Following a transient increase, all rat Klf6 isoforms decreased in response to acute carbon tetrachloride (CCl(4)) liver injury and culture-induced activation. After acute CCl(4), Klf6+/- mice developed significantly increased fibrosis and enhanced fibrogenic messenger RNA (mRNA) and protein expression. In contrast, HSC-specific transgenic mice overexpressing KLF6(WT) or KLF6(SV1) developed significantly diminished fibrosis with reduced expression of fibrogenic genes. Chromatin IP and quantitative reverse-transcription polymerase chain reaction in mouse HSCs overexpressing KLF6(WT) demonstrated KLF6(WT) binding to GC boxes in promoters of Colα1 (I), Colα2 (I), and beta-platelet-derived growth factor receptor (β-Pdgfr) with reduced gene expression, consistent with transcriptional repression by KLF6. Stellate cells overexpressing either KLF6(WT) or KLF6(SV1) were more susceptible to apoptotic stress based on poly (ADP-ribose) polymerase (PARP) cleavage.KLF6 reduces fibrogenic activity of HSCs by way of two distinct mechanisms, direct transcriptional repression of target fibrogenic genes and increased apoptosis of activated HSCs. These results suggest that following its initial induction, sustained down-regulation of KLF6 in liver injury may allow de-repression of fibrogenic genes and decreased stellate cell clearance by inhibiting apoptosis.