tbuckley/cabot-search huggingface dataset:
Quantitative Chemical Analysis. Adapted for Use in the Laboratories of Colleges and Schools.
Authors: Frank Clowes, J. Bernard Coleman
Journal: JAMA (1903)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Snail Genetic Variation Associated With Resistance to Schistosomiasis
Authors: Tracy Hampton
Journal: JAMA (2015)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Infectious Diseases of the Female Genital Tract
Authors: Richard L. Sweet, Ronald S. Gibbs
Journal: Annals of Internal Medicine (1991)

The volume and quality of both basic research and clinic investigation of female genital tract infections have increased significantly in the past 2 decades.  Included among the major changes in studies of reproductive microbiology have been:  an interest in the pathophysiology of infectious processes; the realization that many infections are polymicrobic in nature; recognition of the importance of virus mycoplasma chlamydia and anaerobic micro-organisms; elucidation of a role for newly developed organisms such as Mobiluncus and papillomavirus; the use of quantitative microbiology in reproductive tract investigations; development of a better diagnostic techniques for the identification of micro-organisms and diseases; and a revolution in the availability of antimicrobial agents and in antibiotic treatment strategies.  This comprehensive volume was prepared as a resource for clinicians who provide health care to women in the area of infectious diseases.  Topics of the books 20 chapters include:  clinical microbiology of the female genital tract use of the microbiology laboratory in infectious diseases sexually transmitted diseases pelvic inflammatory disease toxic shock syndrome infectious vulvovaginitis genital mycoplasmas chlamydial infections mixed anaerobic-aerobic pelvic infection postabortal infection and septic shock wound and episiotomy infections pelvic abscess perinatal infections parasitic diseases in pregnancy premature rupture of the membranes intrauterine infection in late pregnancy postpartum infections urinary tract infection antimicrobial agents and antibiotic prophylaxis in obstetrics and gynecology.  The authors objective in preparing this book was to provide physicians with the diagnostic and therapeutic knowledge necessary to prevent the significant morbidity and occasional mortality that occurs secondary to infections in reproductive medicine.
Stop That Smoke!
Authors: Henry Obermeyer
Journal: JAMA (1933)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Abstract 17132: Risk Factors for Anthracycline And/or Herceptin-induced Left Ventricular Systolic Dysfunction
Authors: Yasmin S Hamirani, Ali El Sayed, Patrick Dillon, Andrew Wong, Pooja Mehra, Christopher M Kramer, Michael Salerno
Journal: Circulation (2014)

Introduction: Anthracyclines (ANT) and Herceptin (HER) are known to cause left ventricular (LV) systolic dysfunction and congestive heart failure (CHF). We aimed to identify the clinical risk factors associated with reduced LV function caused by one or both agents. Methods: We retrospectively examined our electronic records for patients that received ANT and/or HER from 2000-2013 and identified 3253 patients. 2704 were excluded for lack of a follow-up EF assessment (2699) or development of CAD (5) after the start of chemotherapy. Of the remaining 216 patients, 27 (12.5%) had a drop in EF after chemotherapy of &gt;10% to below 50% and 185 (86.6%) did not. Kruskal Wallis test and Fisher exact test were utilized to estimate the difference between groups, and logistic regression model was used to predict a fall in EF. Results: More patients with a fall in EF had hypertension (HTN), hyperlipidemia (HL) and CAD (Table). A higher % of patients with a fall in EF received both HER and ANT as compared to ANT alone (36% vs 9.5% p=0.001). Higher use of liposomal doxorubicin was seen in the group with no reduction in EF. The median (IQR) time difference (days) between start of chemotherapy and reduced EF was 213 (76-761) and the doxorubicin dose in this group was 240 (128.5-254) mg/m2. On multivariate analysis hypertension and use of Herceptin remained independent predictors of EF fall. Conclusion: HTN, HL, CAD and concomitant HER use were univariate predictors of EF decline, while only HTN and HER were independent multivariate predictors. Given the prevalence of reduced EF at follow-up, late assessment of EF is indicated to avoid missing chemotherapy-induced cardiotoxicity.
CD 24 expression in cancer of the pancreas.
Authors: Naheed Alam, Thaer Khoury, Jihnhee Yu, Milind Javle
Journal: Cancer Research (2007)

AACR Annual Meeting-- Apr 14-18, 2007; Los Angeles, CA

4387 

Background : CD 24 is a glycosyl phosphatidyl inositol (GPI )-anchored membrane protein that enhances the metastatic potential of malignant cells. It was identified as a ligand of p-selectin, an adhesion receptor on activated endothelial cells and platelets and was associated with poor prognosis and survival in various solid tumors. However, data regarding the role of CD 24 in pancreatic adenocarcinoma is lacking. Our study evaluated CD 24 expression in pancreatic adenocarcinoma and correlated the same to clinicopathological data and survival.

Methods : Between 1993 and 2002, 37 consecutive pancreatic adenocarcinoma patients, surgically treated at Roswell Park Cancer Institute were included. Demographic data, clinical stage, pathology, treatment administered and survival were obtained from medical records in accordance with IRB approval protocol. Immunohistochemical staining was performed on paraffin-embedded sections. CD 24 clone ML5 was provided by BD Pharmingen.. All slides were reviewed by surgical pathologist (TK); histoscores were read as percentage cells positive x staining intensity. Kendall's tau and Pearson correlation tests were employed to investigate the association between the biomarkers and prognostic data. Survival figures of cases with low (= median) and high scores (> median) for each biomarker were compared using the log rank test and the Kaplan-Meier method.

Results: There were 19 males and 18 females. The median age was 65 years (range 38-84). Grade was well differentiated in 2, moderately differentiated in 19 and poorly differentiated in 16. CD 24 was commonly expressed in pancreatic adenocarcinoma (81% of cases). Median survival for patients with low CD 24 was 18 months (95% CI:13 -24) and those with high CD 24 was 11 months (95% CI: 6 - not-estimated) (p=0.7204). Stage was 1 in 9 and 3 in 28. Twenty had Whipple resection, 4 had total pancreatectomy, others (n=13) underwent partial pancreatectomy. Nine had positive margins. Histology: all cases had adenocarcinoma.

Conclusion : CD 24 expression in pancreatic adenocarcinoma is common. Further studies are needed to explain its role in prognosis and use as a therapeutic target.
Abstract 15411: Estrogen Receptor β Mediates Sex Differences in the Proteomic Response of the Heart to Pressure Overload
Authors: Georgios Kararigas, Daniela Fliegner, Stefanie Forler, Oliver Klein, Carola Schubert, Joachim Klose, Vera Regitz-Zagrosek
Journal: Circulation (2014)

Sex differences in the response of the heart to pressure overload (PO) have pointed to estrogen receptor (ER) β, which may be cardioprotective. However, the underlying mechanisms are incompletely defined. In a proteomic analysis of PO-induced hypertrophy, we hypothesized significant sex differences mediated by ERβ. Two-month-old C57BL6 male (M) and female (F) wild-type (WT) and ERβ knockout (BERKO) mice were subjected to transverse aortic constriction (TAC) or sham surgery (n = 4/group). The proteome of left ventricular samples was separated by high-resolution 2-dimensional polyacrylamide gel electrophoresis followed by mass spectrometry. The proteomic data were analyzed with empirical Bayesian-based linear models using R/Bioconductor. Nine weeks after TAC, heart-weight-to-tibia-length ratio was significantly higher in WT M (TAC vs. sham 128%; P < 0.05) than in WT F (TAC vs. sham 54%; P < 0.05) mice (interaction P < 0.001), while this difference in BERKO mice between M (TAC vs. sham 53%; P < 0.05) and F (...
Antinuclear antibodies associate with loss of response to antitumour necrosis factor-α therapy in psoriasis: a retrospective, observational study
Authors: A.E. Pink, A. Fonia, M.H. Allen, C.H. Smith, J.N.W.N. Barker
Journal: British Journal of Dermatology (2009)

Journal Article Antinuclear antibodies associate with loss of response to antitumour necrosis factor‐α therapy in psoriasis: a retrospective, observational study Get access A.E. Pink, A.E. Pink St John's Institute of Dermatology, Guy's and St Thomas' NHS Foundation Trust and Division of Genetics and Molecular Medicine, King's College London, 9th Floor Guy's Tower, Great Maze Pond, London SE1 9RT, U.K. Search for other works by this author on: Oxford Academic Google Scholar A. Fonia, A. Fonia St John's Institute of Dermatology, Guy's and St Thomas' NHS Foundation Trust and Division of Genetics and Molecular Medicine, King's College London, 9th Floor Guy's Tower, Great Maze Pond, London SE1 9RT, U.K. Search for other works by this author on: Oxford Academic Google Scholar M.H. Allen, M.H. Allen St John's Institute of Dermatology, Guy's and St Thomas' NHS Foundation Trust and Division of Genetics and Molecular Medicine, King's College London, 9th Floor Guy's Tower, Great Maze Pond, London SE1 9RT, U.K. Search for other works by this author on: Oxford Academic Google Scholar C.H. Smith, C.H. Smith St John's Institute of Dermatology, Guy's and St Thomas' NHS Foundation Trust and Division of Genetics and Molecular Medicine, King's College London, 9th Floor Guy's Tower, Great Maze Pond, London SE1 9RT, U.K. Search for other works by this author on: Oxford Academic Google Scholar J.N.W.N. Barker J.N.W.N. Barker St John's Institute of Dermatology, Guy's and St Thomas' NHS Foundation Trust and Division of Genetics and Molecular Medicine, King's College London, 9th Floor Guy's Tower, Great Maze Pond, London SE1 9RT, U.K. Jonathan Barker. E‐mail: jonathan.barker@kcl.ac.uk Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 162, Issue 4, 1 April 2010, Pages 780–785, https://doi.org/10.1111/j.1365-2133.2009.09563.x Published: 01 April 2010
Abstract 18656: Boronated Antioxidant Prodrug (BRAP) as a Novel Hydrogen Peroxide-activatable Therapy for Ischemia-reperfusion Injury
Authors: Dongwon Lee, Soochan Bae, Seunggyu Park, Dahee Jeong, Minhyung Park, Mohammed A Samad, Qingen Ke, Peter M Kang
Journal: Circulation (2014)

Generation of high level of H2O2 is the main culprit in the pathogenesis of ischemia/reperfusion (I/R) injury. We generated boronated anti-oxidant prodrug (BRAP), designed to initially react specifically in presence of high level of H2O2 through boronic ester bond, which allows it to be targeted to oxidative stress site. This reaction results in effective scavenging of H2O2 and it releases hydroxybenzyl alcohol, which has intrinsic antioxidant and anti-inflammatory properties. BRAP significantly reduced ROS generation and elevation of inflammation markers after LPS treatment in vitro. BRAP also protected H2O2-induced cell death in adult cardiomyocytes. To explore beneficial effects of BRAP in cardiac I/R injury, cardiac function was evaluated 2 wks after I/R in mice. Pressure volume loop analysis showed that I/R resulted in a significant reduction of cardiac output and stroke work. However, daily intraperitoneal administration of BRAP (1.5 mg/kg) effectively attenuated I/R-induced cardiac dysfunction. Echocardiography also showed that BRAP increased ejection fraction and fractional shortening compared with vehicle I/R mice. Dihydroethidium staining showed BRAP significantly decreased ROS generation after I/R. In addition, BRAP decreased elevation of proinflammatory cytokines compared with vehicle I/R mice. Moreover, BRAP effectively blocked apoptosis with reduction of caspase-3 activation and TUNEL-positive cells. Since oral delivery is the most common and preferred method for long-term drug administration and BRAP is stable in acidic environment, we examined the effectiveness of oral delivery of BRAP in renal I/R injury. The elevation of serum creatinine level as a marker of renal function 24 hr after I/R was significantly reduced by oral delivery of BRAP. BRAP effectively scavenged ROS overproduction and blocked inflammation and apoptosis after I/R in kidney. In the safety profile of BRAP, there were no renal or liver functional abnormalities and no significant histological evidence of accumulated toxicity in various organs associated with administration of high dose of BRAP for 7 days. Therefore, BRAP can be used in targeted therapy for I/R injury with its protective effect of blocking oxidative stress, inflammation, and apoptosis.
Cancer: Principles and Practice of Oncology.
Authors: Vincent T. DeVita, Samuel Hellman, Steven A. Rosenberg
Journal: Annals of Internal Medicine (1991)

Part I: Molecular Biology of Cancer Molecular Methods in Oncology Section 1. Amplification Techniques Section 2. RNA Interference Section 3. cDNA arrays Section 4. Tissue arrays Section 5. Cytogenetics Section 6. Bioinformatics Genomics and Proteomics Molecular Targets in Oncology Section 1. Signal transduction systems Section 2. Cell cycle Section 3. Apoptosis Section 4. Telomerase Invasion and Metastases Angiogenesis Cancer Immunology Part II: Principles of Oncology Etiology of Cancer: Viruses Section 1. RNA Viruses Section 2. DNA Viruses Etiology of Cancer: Chemical Factors Etiology of Cancer: Tobacco Etiology of Cancer: Physical Factors Epidemiology of Cancer Section 1. Epidemiologic Methods Section 2. Cancer Statistics Principles of Surgical Oncology Section 1. General Issues Section 2. Laparascopic Surgery Principles of Radiation Oncology Principles of Medical Oncology Pharmacology of Cancer Chemotherapy Section 2. Pharmocokinetics Section 3. Pharmacogenomics Section 4. Alkylating Agents Section 5. Cisplatin and its Analogues Section 6. Antimetabolites Section 7. Topoisomerase Interactive Agents Section 8. Antimicrotubule Agents Section 9. Miscellaneous Chemotherapeutic Agents Pharmacology of Cancer Biotherapeutics Section 1. Interferon Section 2. Interleukin 2 Section 3. Histone deacetylase inhibitors as differentiation agents Section 4. Monoclonal Antibodies Pharmacology of Endocrine Manipulation Design and Analysis of Clinical Trials Part III: Practice of Oncology Cancer Prevention: Preventing Tobacco-Related Cancers Cancer Prevention: Diet and Chemopreventive Agents Section 1. Dietary fat Section 2. Dietary Fiber Section 3. Dietary fruits and vegetables: naturally occurring anticarcinogens Section 4. Retinoids, carotenoids and micronutrients Section 5. Dietary Carcinogens Section 6. Cyclo-oxygenase inhibitors Section 7. Physical Activity and Body Weight Cancer Prevention: Role of Surgery in Cancer Prevention Cancer Screening Advanced Molecular Diagnostics Advanced Imaging Methods Section 1. Functional and Metabolic Imaging Section 2. Interventional Radiology Cancer Diagnosis: Endoscopy Section 1. Gastrointestinal endoscopy Section 2. Respiratory Tract Cancer of the Head and Neck Section 1. Molecular Biology of Head and Neck Tumors Section 2. Treatment of Head and Neck Cancers Section 3. Rehabilitation after Treatment for Head Cancer of the Lung Section 1. Molecular Biology of Lung Cancer Section 2. Non-small Cell Lung Cancer Section 3. Small Cell Lung Cancer Neoplasms of the Mediastinum Cancers of the Gastrointestinal Tract
The Mental Status Exam
Authors: Daniel M. Becker
Journal: JAMA (2000)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Work stress and low sense of coherence is associated with type 2 diabetes in middle-aged Swedish women : Diabetes Care
Authors: E. E. Agardh, A. Ahlbom, T. Andersson, S. Efendic, V. Grill, J. Hallqvist, A. Norman, C. G. Ostenson
Journal: Diabetes Care (2003)

Work stress and low sense of coherence is associated with type 2 diabetes in middle-aged Swedish women : Diabetes Care
Identification of the NUP98-PHF23 fusion gene in pediatric cytogenetically normal acute myeloid leukemia by whole-transcriptome sequencing
Authors: Marco Togni, Riccardo Masetti, Martina Pigazzi, Annalisa Astolfi, Daniele Zama, Valentina Indio, Salvatore Serravalle, Elena Manara, Valeria Bisio, Carmelo Rizzari, Giuseppe Basso, Andrea Pession, Franco Locatelli
Journal: Journal of Hematology & Oncology (2015)

The genomic landscape of children with acute myeloid leukemia (AML) who do not carry any cytogenetic abnormality (CN-AML) is particularly heterogeneous and challenging, being characterized by different clinical outcomes. To provide new genetic insights into this AML subset, we analyzed through RNA-seq 13 pediatric CN-AML cases, corroborating our findings in an independent cohort of 168 AML patients enrolled in the AIEOP AML 2002/01 study. We identified a chimeric transcript involving NUP98 and PHF23, resulting from a cryptic t(11;17)(p15;p13) translocation, demonstrating, for the first time, that NUP98-PHF23 is a novel recurrent (2.6%) abnormality in pediatric CN-AML.
Brief Report: On a Regulatory System of the Adenine Level in the Plasma Connected with Red Cell Maturation and its Effect on the Adenine Nucleotides of the Circulating Erythrocyte. Lack of Relation Between ATP-Level and Life Span of the Erythrocyte
Authors: I. SYLLM-RAPOPORT, G. JACOBASCH, S. PREHN, S. RAPOPORT
Journal: Blood (1969)
538. Functional Correction of A-T Cells by ATM Gene Expression Mediated by HSV Amplicon Vector after the Ionizing Radiation or under Oxidative Stress Condition
Authors: Ryan Manuszak, Rodney Shackelford, Charles J. Link, Suming Wang
Journal: Molecular Therapy (2004)

Ataxia-telangiectasia (A-T) is a progressive degenerative autosomal recessive disease characterized by ataxia, telangiectases, immune dysfunction, cancer predisposition, and sensitivity to ionzing radiation. Presently, there is no treatment to slow the clinical progression of A-T, or improve A-T cell function. Therefore individuals with A-T receive supportive treatment only. For this reason, gene therapy, particularly for the organs effected in A-T (i.e. the cerebellum and hematopoietic cells), is being considered as a therapeutic measure for treating A-T patients. Previously, we employed a Herpes simplex viral (HSV) amplicon vector (pTO-ATM) to transfer the ATM gene into both the ATM-deficient AT22 cell line and into rat brains, and demonstrated functional expression of the ATM gene. In this study, we will present the functional restoration of the normal phenotype, as ATM gene transfer resulted in increased resistance to oxidative stress and ionizing radiation in cultured primary A-T cells, as measured by the colony forming-efficiency assay. These studies should lay important groundwork for furthering gene therapy approaches for A-T patients.