tbuckley/cabot-search huggingface dataset:
The Effects of Oxygen Breathing in Patients with Acute Myocardial Infarction
Authors: G. L. Foster, G. G. Casten, T. J. Reeves
Journal: Cardiovascular Research (1969)

Journal Article The Effects of Oxygen Breathing in Patients with Acute Myocardial Infarction Get access Glenn L. Foster, Glenn L. Foster From the Department of Medicine, Division of Cardiology, Medical College of Alabama, Birmingham, Alabama, U.S.A. Search for other works by this author on: Oxford Academic PubMed Google Scholar Gus G. Casten, Gus G. Casten From the Department of Medicine, Division of Cardiology, Medical College of Alabama, Birmingham, Alabama, U.S.A. Search for other works by this author on: Oxford Academic PubMed Google Scholar T. J. Reeves, T. J. Reeves From the Department of Medicine, Division of Cardiology, Medical College of Alabama, Birmingham, Alabama, U.S.A. Search for other works by this author on: Oxford Academic PubMed Google Scholar with Statistical Analysis by David C. Hurst with Statistical Analysis by David C. Hurst Search for other works by this author on: Oxford Academic PubMed Google Scholar Cardiovascular Research, Volume 3, Issue 2, April 1969, Pages 179–189, https://doi.org/10.1093/cvr/3.2.179 Published: 01 April 1969 Article history Received: 10 June 1968 Published: 01 April 1969
The Prevalence of Occult Gastrointestinal Bleeding in Celiac Sprue
Authors: Kenneth D. Fine
Journal: New England Journal of Medicine (1996)

Iron deficiency complicating celiac sprue is usually attributed to the malabsorption of dietary iron or the loss of iron from the intestinal mucosa. There has been little investigation of the role of intestinal loss of blood in patients with this condition. The purpose of this study was to determine the prevalence of occult gastrointestinal bleeding in patients with celiac sprue.
15th International Congress On Occupational Health
Authors: FRANCIS J. HARVEY
Journal: JAMA (1966)

<h3>To the Editor:</h3> This congress, which is held every three years, took place in Vienna, Sept 19 to 24, 1966. The site was the famous University of Vienna, which celebrated its sixth centennial in 1965. The opening session was held in the Aula, the huge yard of the university. In its center stands the symbol of the Alma Mater, and the galleries contain the busts of the renowned Austrian physicians Billroth, Oppolzer, Skoda, Nothnagel, and Wagner-Jauregg. Franz Jonas, the president of Austria, opened the congress. Dr. Breitenecker, the president of the congress, stressed the growing importance of occupational health. More than 2,500 physicians from 54 countries were in attendance and the congress proceedings alone fill not less than 12 volumes. The remarkable number of participants from Japan is explained by the selection of Tokyo as the site of the next International Congress on Occupational Health in 1969. Three languages were
The Role of Hormone Receptors in the Action of Adrenal Steroids
Authors: D Feldman
Journal: Annual Review of Medicine (1975)

Extensive investigation indicates that all steroid hormones appear to have similar subcellular mechanisms of action. This recognition of a general pattern has led to a unified hypothesis of steroid action and has facilitated efforts to elucidate the underlying mechanisms. Although differences may exist in the details of their ac­ tion, and each steroid possesses unique properties, a generally accepted sequence of events applicable to all steroid hormones has been postulated: (a) binding of the hormone to cytoplasmic receptors in target cells and subsequent translocation of this steroid-receptor complex to a nuclear acceptor site, (b) activation of the genome by an as yet unknown mechanism leading to increased RNA synthesis and resulting in the induction of new protein, and (c) mediation of the biological effects of the hormone by the induced protein. The present discussion will be limited to recent developments involving adrenal steroids and will concentrate on the first phase of the above sequence-the role of the receptor. Reviews of various aspects of steroid action have been published recently (1-5).
A Cost-Effective Analysis of the U.S. Varicella Zoster Virus (VZV) Vaccination Program with Consideration for Delayed Onset of Asthma Following Vzv Infection
Authors: Jared B. Ditkowsky, Stephan Kohlhoff, Jonathan Silverberg, Tamar A. Smith-Norowitz
Journal: Journal of Allergy and Clinical Immunology (2015)
Identification of Enterococci
Authors: George Demko
Journal: JAMA (1975)

<h3>To the Editor.—</h3> The report by Neefe et al on<i>Streptococcus mutans</i>endocarditis (230:1298-1299,1974) refers to two media employed for the differentiation of enterococci,<i>S faecalis</i>broth and Enterococcosel broth, and indicates that some strains of<i>S mutans</i>can also grow in these media. In addition to these two broths, several other media are available for the differentiation of group D streptococci or enterococci. As indicated in the Table, each of these media is unique in the amount of either bile or esculinpresent. In addition, all of the media except Bile Esculin Agar also contain sodium azide. Since these three ingredients are the major selective and differential components of the media, it is important to keep these differences in mind when using these media in any identification scheme. In a much larger survey than that of Neefe et al, Facklam and his colleagues<sup>1</sup>have evaluated various alternative biochemical
Hepatic growth hormone receptor, insulin-like growth factor I, and insulin-like growth factor-binding protein messenger RNA expression in pediatric liver disease
Authors: R I Holt, P A Crossey, J S Jones, A J Baker, B Portmann, J P Miell
Journal: Hepatology (1997)

Major changes in serum levels of insulin-like growth factor I (IGF-I) and IGF-binding proteins (IGFBPs) occur in children with end-stage liver disease in association with changes in body composition. We hypothesized that these changes would be associated with changes in hepatic messenger RNA (mRNA) expression. Eleven children with end-stage extrahepatic biliary atresia and 11 controls (liver donors) were studied. Serum samples were obtained from the children with biliary atresia immediately before orthotopic liver transplantation. Serum IGF- I, IGFBP-1, and IGFBP-2 levels were measured by radioimmunoassay, and IGFBP-3 by immunoradiometric assay. In both groups, growth hormone receptor mRNA expression was examined by quantitative reverse transcription-polymerase chain reaction, IGF-I mRNA expression by ribonuclease protection assay, and IGFBP-1 to -4 mRNA expression by Northern analysis. Growth hormone receptor and IGF-I mRNA levels were reduced 1.7-fold ( P = .003) and 9.6-fold ( P = .0001) in biliary atresia compared with levels in controls. Despite increased serum IGFBP-1 levels and reduced IGFBP-3 levels in biliary atresia, there was no change in either IGFBP-1 or IGFBP-3 mRNA expression. In contrast, serum levels and mRNA expression of IGFBP-2 were increased 1.6-fold ( P = .003) and twofold ( P = .0001), respectively, compared with controls. Gene expression did not correlate with liver dysfunction or body composition. Changes in growth hormone receptor and IGF-I mRNA expression may account for the reduction in serum IGF-I found in pediatric liver disease. In contrast, the marked alteration in circulating IGFBP levels was not accompanied by changes in hepatic IGFBP gene expression, suggesting that posttranslational mechanisms may be important.
Relapsing Coombs-negative haemolytic anaemia in pregnancy with haemolytic disease in the newborn.
Authors: A Eldor, S Yatziv, C Hershko
Journal: BMJ (1975)

Relapsing Coombs-negative haemolytic anaemia in pregnancy with haemolytic disease in the newborn A rare form of acquired haemolytic anaemia is Coombs-negative haemolytic disease restricted to the period of pregnancy.'-3Unlike previously reported cases, in our patient transient haemolytic disease developed in the infant also, lending support to the assumption of an autoimmune mechanism. Case reportThe patient was first examined because of anaemia in March 1959 at the age of 25 in the 8th month of pregnancy.Anaemia had also been present during her first pregnancy, but no further investigations were done.During the third month of the second pregnancy weakness, palpitations, and exertional dyspnoea developed.She was pale.The liver and spleen were not
Distinct contracted conformations of the <i>Tcra/Tcrd</i> locus during <i>Tcra</i> and <i>Tcrd</i> recombination
Authors: Han-Yu Shih, Michael S. Krangel
Journal: The Journal of Experimental Medicine (2010)

Studies have suggested that antigen receptor loci adopt contracted conformations to promote long-distance interactions between gene segments during V(D)J recombination. The Tcra/Tcrd locus is unique because it undergoes highly divergent Tcrd and Tcra recombination programs in CD4−CD8− double negative (DN) and CD4+CD8+ double positive (DP) thymocytes, respectively. Using three-dimensional fluorescence in situ hybridization, we asked whether these divergent recombination programs are supported by distinct conformational states of the Tcra/Tcrd locus. We found that the 3′ portion of the locus is contracted in DN and DP thymocytes but not in B cells. Remarkably, the 5′ portion of the locus is contracted in DN thymocytes but is decontracted in DP thymocytes. We propose that the fully contracted conformation in DN thymocytes allows Tcrd rearrangements involving Vδ gene segments distributed over 1 Mb, whereas the unique 3′-contracted, 5′-decontracted conformation in DP thymocytes biases initial Tcra rearrangements to the most 3′ of the available Vα gene segments. This would maintain a large pool of distal 5′ Vα gene segments for subsequent rounds of recombination. Thus, distinct contracted conformations of the Tcra/Tcrd locus may facilitate a transition from a Tcrd to a Tcra mode of recombination during thymocyte development.
Guidelines of care for androgenetic alopecia
Authors: Lynn A. Drake, Scott M. Dinehart, Evan R. Farmer, Robert W. Goltz, Gloria F. Graham, Maria K. Hordinsky, Charles W. Lewis, David M. Pariser, Stephen B. Webster, Duane C. Whitaker, Barbara Butler, Barbara J. Lowery, Vera H. Price, Howard Baden, Richard L. DeVillez, Elise Olsen, Jerome L. Shupack
Journal: Journal of the American Academy of Dermatology (1996)
Torturers, horror films, and the aesthetic legacy of predation
Authors: Lionel Tiger
Journal: Behavioral and Brain Sciences (2006)

A Rousseauist bias towards the study of human aggression has treated it as a regrettable anomaly rather than a volatile reflection of important forces in human evolution. Intrepidly, Nell displays the arc of connection between predation in humans and other animals and the neurophysiological factors that underlie chronic interest in accident, death, and harsh force.
SCINTIGRAPHIC ASSESSMENT OF LEUKOCYTE INFILTRATION OF FLUID COLLECTION IN PATIENTS WITH ACUTE PANCREATITIS USING TECHNETIUM 99m HEXAMETHYL PROPYLENE AMINE OXIME (Tc-99m-HMPAO) AS A LEUKOCYTE LABEL
Authors: S. A. Ali, F. Cesani, E. Walser
Journal: Clinical Nuclear Medicine (1995)
Molecular and Functional Characterization of Novel Glycerol-3-Phosphate Dehydrogenase 1–Like Gene ( <i>GPD1-L</i> ) Mutations in Sudden Infant Death Syndrome
Authors: David W. Van Norstrand, Carmen R. Valdivia, David J. Tester, Kazuo Ueda, Barry London, Jonathan C. Makielski, Michael J. Ackerman
Journal: Circulation (2007)

Autopsy-negative sudden unexplained death, including sudden infant death syndrome, can be caused by cardiac channelopathies such as Brugada syndrome (BrS). Type 1 BrS, caused by mutations in the SCN5A-encoded sodium channel, accounts for approximately 20% of BrS. Recently, a novel mutation in the glycerol-3-phosphate dehydrogenase 1-like gene (GPD1-L) disrupted trafficking of SCN5A in a multigenerational family with BrS. We hypothesized that mutations in GPD1-L may be responsible for some cases of sudden unexplained death/sudden infant death syndrome.Using denaturing high-performance liquid chromatography and direct DNA sequencing, we performed comprehensive open-reading frame/splice site mutational analysis of GPD1-L on genomic DNA extracted from necropsy tissue of 83 unrelated cases of sudden unexplained death (26 females, 57 males; average age, 14.6+/-10.7 years; range, 1 month to 48 years). A putative, sudden unexplained death-associated GPD1-L missense mutation, E83K, was discovered in a 3-month-old white boy. Further mutational analysis was then performed on genomic DNA derived from a population-based cohort of 221 anonymous cases of sudden infant death syndrome (84 females, 137 males; average age, 3+/-2 months; range, 3 days to 12 months), revealing 2 additional mutations, I124V and R273C, in a 5-week-old white girl and a 1-month-old white boy, respectively. All mutations occurred in highly conserved residues and were absent in 600 reference alleles. Compared with wild-type GPD1-L, GPD1-L mutations coexpressed with SCN5A in heterologous HEK cells produced a significantly reduced sodium current (P<0.01). Adenovirus-mediated gene transfer of the E83K-GPD1-L mutation into neonatal mouse myocytes markedly attenuated the sodium current (P<0.01). These decreases in current density are consistent with sodium channel loss-of-function diseases like BrS.The present study is the first to report mutations in GPD1-L as a pathogenic cause for a small subset of sudden infant death syndrome via a secondary loss-of-function mechanism whereby perturbations in GPD1-L precipitate a marked decrease in the peak sodium current and a potentially lethal BrS-like proarrhythmic substrate.
RECENT ADVANCES IN ACTINOTHERAPY.
Authors: WILLIAM S. GOTTHEIL
Journal: JAMA (1904)

Young as is the treatment of disease by the various forms of radiant energy, there is already confusion in its terminology, and it will not be out of place to begin this review with the statement that the term "actino-therapy" is now the accepted designation for the method that employs the violet and ultraviolet spectral rays. The<i>x</i>-ray treatment is known as "radiotherapy," while "phototherapy" is employed for all kinds of light treatment collectively. There is need for insistence on exactitude in the employment of these terms, and even some of those who especially occupy themselves with photo-therapeutics are open to criticism in this regard. Thus Freund entitles the authoritative work that he has just published<i>"Grundriss der Gesammten Radiotherapie,"</i>'including therein not only the Röntgen treatment, but also that by high-frequency currents, Becquerel rays, visible and ultraviolet light rays, and even heat rays. The latter
Investigating the Utility of Circulating-Free Tumour-Derived Dna (CTDNA) in Plasma for the Detection of Epidermal Growth Factor Receptor (EGFR) Mutation Status in European and Japanese Patients (PTS) with Advanced Non-Small-Cell Lung Cancer (ANSCLC): Assess Study
Authors: M. Reck, K. Hagiwara, B. Han, S. Tjulandin, C. Grohe, T. Yokoi, A. Morabito, R. McCormack, M. Ratcliffe, N. Normanno
Journal: Annals of Oncology (2015)
Benign Duodenocolic Fistula
Authors: Gregory J. Gallivan
Journal: JAMA (1969)

To the Editor:.—  Benign duodenocolic fistula is infrequent. Most follow carcinoma of the transverse colon. The first fully documented benign case was that of Sanderson in 1963. 1 Starzl et al reviewed 24 cases from English, French, and Italian journals. A previous review uncovered an additional 29 cases documented between 1893 and 1967. 3 Fully one sixth of all cases have had the point of origin in a duodenal diverticulum.  Report of a Case:—  A 76-year-old white man was hospitalized on May 6, 1966, with bloody diarrhea and syncope. Barium enema examination revealed a fistulous tract extending from the duodenum into a cavity communicating with the transverse colon. A preherniorrhaphy barium enema in September 1965 had revealed only colonic diverticulosis on the left side.  The patient was readmitted June 30, 1966, with a temperature of 39.5 C, diarrhea, feculent vomiting, and pain in the abdomen. Blood cultures revealed nonhemolytic streptococcus,
Response to Letters Regarding Article, “Free Fatty Acid Depletion Acutely Decreases Cardiac Work and Efficiency in Cardiomyopathic Heart Failure”
Authors: Helena Tuunanen, Alexandru Naum, Kjell Någren, Pirjo Nuutila, Patricia Iozzo, Heikki Ukkonen, Juhani Knuuti, Erik Engblom, K.E. Juhani Airaksinen, Birger Hesse, Lionel H. Opie
Journal: Circulation (2007)
Selective anergy of V beta 8+ T cells in human immunodeficiency virus-infected individuals.
Authors: G Dadaglio, S Garcia, L Montagnier, M L Gougeon
Journal: The Journal of Experimental Medicine (1994)

We have analyzed the V beta usage by CD4+ and CD8+ T cells from human immunodeficiency virus (HIV)-infected individuals in response to an in vitro stimulation with the superantigenic erythrogenic toxin A (ETA) of Streptococcus pyogenes. ETA amplifies specifically CD4+ and CD8+ T cells from control donors expressing the V beta 8 and the V beta 12 elements. When peripheral T cells from asymptomatic HIV-infected individuals were stimulated with ETA, there was a complete lack of activation of the V beta 8+ T cell subset, whereas the V beta 12+ T cell subset responded normally to the superantigen. This V beta-specific anergy, which was also observed in response to staphylococcal enterotoxin E (SEE), affected both CD4+ and CD8+ T cells and represented an intrinsic functional defect rather than a specific lack of response to bacterial superantigens since it was also observed after a stimulation with V beta 8 monoclonal antibodies. The V beta 8 anergic T cells did not express interleukin 2 receptors (IL-2Rs) and failed to proliferate in response to exogenous IL-2 or IL-4, suggesting that this anergy was not a reversible process, at least by the use of these cytokines. The unresponsiveness of the V beta 8 T cell subset is frequent since it was found in 56% of the patients studied, and comparison of the clinical status of responder vs. anergic patients indicated that the only known common factor between them was HIV infection. In addition, it is noteworthy that the anergy of the V beta 8 subset may be a very early phenomenon since it was found in a patient at Centers for Disease Control stage I of the disease. These data provide evidence that a dominant superantigen may be involved in the course of HIV infection and that the contribution of HIV has to be considered.
Suppression of foreign body granuloma by recombinant interferon.
Authors: A Nethersell, K Sikora, T Wheeler, P Conn
Journal: BMJ (1984)

Une observation. Granulomes dus a des corps etrangers (talc) apparaissant 8 ans apres chirurgie pour tumeur carcinoide du poumon. Le traitement par interferon amene une regression importante de ces granulomes, sans modifier les metastases de tumeur carcinoide dans d'autres organes
Identification of a thermolabile component of the human neutrophil NADPH oxidase. A model for chronic granulomatous disease caused by deficiency of the p67-phox cytosolic component.
Authors: R W Erickson, S E Malawista, M C Garrett, G Van Blaricom, T L Leto, J T Curnutte
Journal: Journal of Clinical Investigation (1992)

Mild heating of human neutrophils inactivates the respiratory burst oxidase, producing a defect in superoxide production and bacterial killing comparable to that seen in patients afflicted with chronic granulomatous disease (CGD). We have now investigated the mechanism and specificity of this inactivation by examining the effect of mild heating on the known oxidase components: the membrane-bound subunits of the cytochrome b558 (gp91-phox and p22-phox) and the two cytosolic oxidase factors (p47-phox and p67-phox). Heating (46 degrees C for 7.5 min) caused intact neutrophils to lose greater than 85% of their capacity to produce superoxide, a defect which was localized to the cytosolic, but not the membrane, fraction. Complementation studies with CGD cytosols deficient in either p47-phox or p67-phox suggested that the defective component of heat-inactivated cytosol was p67-phox. This was confirmed by experiments showing that recombinant p67-phox, but not p47-phox, exhibited lability at 46 degrees C and completely reconstituted oxidase activity of heat-treated cytosol. These studies indicate that mild heating of either intact neutrophils or normal neutrophil cytosol results in a selective inactivation of p67-phox, providing a model oxidase system for the extremely rare p67-phox-deficient form of CGD.
RECENT ADVANCES IN THE STUDY OF MEASLES AND MEASLES VACCINATION
Authors: Harris D. Riley
Journal: JAMA (1960)

Measles (rubeola), in addition to being one of the most infective, is one of the most serious of the common diseases of childhood. While antimicrobial agents have played an important role in decreasing the severity of secondary infections and passive immunization with gamma globulin has been of unquestioned benefit, the morbidity and mortality from measles is still quite high. In the United States in 1958, 552 deaths were attributed to measles, and total mortality from measles now exceeds that of poliomyelitis. The incidence of secondary bacterial complications of measles is reported as 15 per cent and 18.5 per cent in two separate studies of non-hospitalized children. In addition to the mortality and morbidity of measles, it has been estimated that 1 child in 1,000 with measles develops encephalitis and approximately one-third of these either die or exhibit permanent neurological residuals. The deleterious effect of measles on pulmonary tuberculosis, cystic fibrosis
Current Status of Capsule Endosccopy - Summaries from the 4<sup>th</sup>International Conference on Capsule Endoscopy (ICCE 2005)
Authors: T. Rösch
Journal: Endoscopy (2005)

We are glad to present a series of papers in which capsule experts and enthusiasts present their integrated view of indications and clinical situations in which capsule endoscopy will or should have a role. The following papers are based on the 4th International Conference on Capsule Endoscopy, a symposium organized and sponsored by Given Imaging, and present the consensus opinion among the authors and not that of an endoscopic society such as ESGE or others. Nevertheless, these papers are meant to provide an interesting overview of the current status of capsule endoscopy and will hopefully serve to stimulate further research.