THE PROTHROMBINOPENIC EFFECT OF MASSIVE SALICYLATE THERAPY IN ACUTE RHEUMATIC FEVER
Authors: G C OWEN, H A BRADFORD
Journal: Annals of Internal Medicine (1946)

Article1 July 1946THE PROTHROMBINOPENIC EFFECT OF MASSIVE SALICYLATE THERAPY IN ACUTE RHEUMATIC FEVERGEORGE C. OWEN, M.D., F.A.C.P., HENRY A. BRADFORD, M.D., F.A.C.P.GEORGE C. OWEN, M.D., F.A.C.P.Search for more papers by this author, HENRY A. BRADFORD, M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-25-1-97 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptFollowing the appearance of Coburn's report1 advocating large doses of salicylates in rheumatic fever, interest in the problem of salicylate intoxication has increased and warnings have been sounded regarding the dangers of salicylate therapy.2, 3 Stress has been laid upon hemorrhage as one of the most striking of these complications, and case reports are cited of deaths from hemorrhage, but prothrombin levels were not determined in any of the fatal cases reported.4, 5Quick questioned the rôle of salicylate hypoprothrombinemia in the production of fatal hemorrhage, on the grounds that no evidence had been offered that prothrombin levels could be...Bibliography1. COBURN AF: Salicylate therapy in rheumatic fever, Bull. Johns Hopkins Hosp., 1943, lxxiii, 435. Google Scholar2. Editorial: Is aspirin a dangerous drug? Jr. Am. Med. Assoc., 1944, cxxiv, 777. Google Scholar3. Editorial: Hazards in the salicylate treatment of rheumatic fever, Jr. Am. Med. Assoc., 1945, cxxvii, 460. Google Scholar4. ASHWORTHMCKEMIE CTJF: Hemorrhagic complications with death probably from salicylate therapy, Jr. Am. Med. Assoc., 1944, cxxvi, 806. CrossrefGoogle Scholar5. TROLLMENTEN MMML: Salicylate poisoning, Am. Jr. Dis. Child., 1945, lxix, 37. CrossrefGoogle Scholar6. QUICK AJ: Correspondence, Jr. Am. Med. Assoc., 1944, cxxvi, 1167. CrossrefGoogle Scholar7. FASHENAWALKER GJJN: Salicylate intoxication: studies on the effects of sodium salicylate on prothrombin time and alkali reserve, Am. Jr. Dis. Child., 1944, lxviii, 369. Google Scholar8. MAGATH TB: Technic of the prothrombin time, Am. Jr. Clin. Path., 1939, ix (Tech. suppl.) 187. CrossrefGoogle Scholar9. SHAPIROREDISHCAMPBELL SMHHA: Studies on prothrombin. IV. The prothrombinopenic effect of salicylates in man, Proc. Soc. Exper. Biol. and Med., 1943, liii, 251. CrossrefGoogle Scholar10. LINKOVERMANSULLIVANHUEBNERSCHEEL KPRSWRCFLD: Studies on the hemorrhagic sweet clover disease. XI. Hypoprothrombinemia in the rat induced by salicylic acid, Jr. Biol. Chem., 1943, cxlvii, 463. CrossrefGoogle Scholar11. STAHMANNHUEBNERLINK MACFKP: Studies on the hemorrhagic sweet clover disease. V. Identification and synthesis of the hemorrhagic agent, Jr. Biol. Chem., 1941, cxxxviii, 513. CrossrefGoogle Scholar12. HUEBNERLINK CFKP: Ibid., 1941, cxxxviii, 529. Google Scholar13. MEYERHOWARD OOB: Production of hypoprothrombinemia and hypocoagulability of the blood with salicylates, Proc. Soc. Exper. Biol. and Med., 1943, liii, 234. CrossrefGoogle Scholar14. RAPOPORTWINGGUEST SMGM: Hypoprothrombinemia after salicylate administration in man and rabbits, Proc. Soc. Exper. Biol. and Med., 1943, liii, 40. CrossrefGoogle Scholar15. COOMBSWARRENHIGLEY FSHACS: Toxicity of salicylates, Jr. Lab. and Clin. Med., 1945, xxx, 378. Google Scholar16 BUTTLEAKESOLLEYGRIFFITHHUNTINGTONMONTGOMERY HRWHRFGCRWH: Rheumatic fever, Jr. Am. Med. Assoc., 1945, cxxviii, 1195. CrossrefGoogle Scholar17. SHAPIRO S: Studies on prothrombin. VI. The effect of synthetic vitamin K on the prothrombinopenia induced by salicylates in man, Jr. Am. Med. Assoc., 1944, cxxv, 546. CrossrefGoogle Scholar18. KAPNICKSTEWARTLYONS IJDC: Plasma prothrombin and liver function during sulphonamide therapy, New England Jr. Med., 1942, ccxxvii, 944. CrossrefGoogle Scholar19. CLAUSENJAGER FWBV: Relation of the plasma salicylate level to the degree of hypoprothrombinemia, Jr. Lab. and Clin. Med., 1946, xxxi, 428. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: *Received for publication October 15, 1945. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byCoagulopathy and bleeding associated with salicylate toxicitySalicylate poisoning: An evidence-based consensus guideline for out-of-hospital managementSALICYLATE-INDUCED HYPOPROTHROMBINEMIACertain Environmental Conditions and Hematological DisordersAnticoagulants in the Management of Various Thromboembolic DiseasesAn Evaluation of Reported Poisonings by Acetylsalicylic AcidDrugs in the Treatment of Rheumatic DisordersPlasma-Volume Determinations in Rheumatic Subjects during Oral Salicylate TherapyHematologyThe Necessity and Possibility of giving Detoxified Large Oral Doses of Salicylates in the Treatment of Rheumatic Fever in Order to Prevent or Cure the Inflammatory Stage of CarditisRecent Advances in Hematology 1 July 1946Volume 25, Issue 1Page: 97-102KeywordsHemorrhageHemorrhagic feversHyperthermiaIntoxicationRheumatic feverSalicylates ePublished: 1 December 2008 Issue Published: 1 July 1946 PDF downloadLoading ...