SARCOIDOSIS WITH THROMBOCYTOPENIA: REPORT OF A CASE
Authors: M H EDWARDS, J A WAGNER, L A M KRAUSE
Journal: Annals of Internal Medicine (1952)

Case Reports1 October 1952SARCOIDOSIS WITH THROMBOCYTOPENIA: REPORT OF A CASEMARGARET HAY EDWARDS, M.D., JOHN A. WAGNER, M.D., LOUIS A. M. KRAUSE, M.D., F.A.C.P.MARGARET HAY EDWARDS, M.D.Search for more papers by this author, JOHN A. WAGNER, M.D.Search for more papers by this author, LOUIS A. M. KRAUSE, M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-37-4-803 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptAlthough involvement of the spleen in sarcoidosis is relatively common,1concomitant occurrence of splenic thrombocytopenia has not been widely noted. Recently, Partenheimer and Meredith2reported a case of splenomegaly and neutropenia occurring in sarcoidosis which was relieved by splenectomy, and referred to six additional cases in the literature. Dameshek,3in a review of hypersplenism, presented a case of splenic pancytopenia with nonhemolytic anemia secondary to the splenomegaly of sarcoidosis in which all the blood elements, including platelets, were depressed prior to splenectomy and elevated thereafter. Kunkel and Yesner4were able to collect from the literature seven cases of sarcoid granulomata...Bibliography1. Freiman DG: Medical progress: sarcoidosis, New England J. Med. 239: 664, 1948. CrossrefMedlineGoogle Scholar2. PartenheimerMeredith RCHC: Splenomegaly with hypersplenism due to sarcoidosis, New England J. Med. 243: 810, 1950. CrossrefMedlineGoogle Scholar3. DameshekEstren WS: Hypersplenism, M. Clin. North America 34: 127, 1950. Google Scholar4. KunkelYesner PR: Thrombocytopenic purpura associated with sarcoid granuloma of the spleen, Arch. Path. 50: 778, 1950. Google Scholar5. EhrlichSchwartz LSO: Splenomegaly in thrombocytopenic purpura, Am. J. M. Sc. 221: 158, 1951. CrossrefMedlineGoogle Scholar6. CattellWilson RBRO: Sarcoidosis of the spleen: report of two cases, Lahey Clin. Bull. 7: 66, 1951. MedlineGoogle Scholar7. Moolton SE: Studies on extractable factors in the spleen and other organic sources which influence the blood platelet count, J. Mt. Sinai Hosp. 12: 866, 1945. Google Scholar8. PlattZeller WROA: Possible effects of hypersplenic extracts on the hematopoietic organs of mice, Arch. Path. 51: 38 (Jan.) 1951. Google Scholar9. WrightDoanBouroncleZollinger CSCABARM: Direct splenic arterial and venous blood studies in the hypersplenic syndromes before and after epinephrine, Blood 6: 195 (March) 1951. CrossrefMedlineGoogle Scholar10. TrolandLee CEF: A preliminary report on a platelet-reducing substance in the spleen of thrombocytopenic purpura, Bull. Johns Hopkins Hosp. 62: 85, 1938. Google Scholar11. Thrombocytopen: Substance in the extract from the spleen of patients with idiopathic thrombocytopenic purpura that reduces the number of blood platelets, J. A. M. A. 111: 221, 1938. CrossrefGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: MARGARET HAY EDWARDS, M.D.; JOHN A. WAGNER, M.D.; LOUIS A. M. KRAUSE, M.D., F.A.C.P.Affiliations: Baltimore, Maryland*Received for publication August 15, 1951.From the Departments of Medicine and Pathology, Lutheran Hospital of Maryland, Baltimore, and the University of Maryland School of Medicine, Baltimore. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byThe Clinical Significance of the SpleenSarkoidose(20) Sarcoidosis and thrombocytopenic purpuraEtiology and therapy of thrombocytopenia associated with sarcoidosisSplenectomy for hematologic disordersBoeck's Sarcoid of the Ocular Fundus*Sarcoidosis of the SpleenSarcoidosis in ChildhoodTHE RIDDLE OF SARCOIDOSIS (HUTCHINSON-BOECK GRANULOMATOSIS)*WILLIAM S. MIDDLETON, M.D., M.A.C.P. 1 October 1952Volume 37, Issue 4 Page: 803-812 Keywords Anemia Blood Hospital medicine Neutropenia Platelets Sarcoidosis Spleen Splenectomy Splenomegaly ePublished: 1 December 2008 Issue Published: 1 October 1952 PDF downloadLoading ...