Increased Incidence of Acute Promyelocytic Leukemia in Patients with Ulcerative Colitis
Authors: JANET CUTTNER
Journal: Annals of Internal Medicine (1982)

Brief Reports1 December 1982Increased Incidence of Acute Promyelocytic Leukemia in Patients with Ulcerative ColitisJANET CUTTNER, M.D.JANET CUTTNER, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-97-6-864 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptUlcerative colitis is an inflammatory disease of unknown origin. Immune mechanisms are now considered important in the etiology of this disease (1-3). Recognized hematologic complications in this disorder include iron deficiency anemia related to bleeding, and Coombs' positive hemolytic anemia associated with the drug salicylazosulfapyridine (Azulfidine, Pharmacia Laboratories, Piscataway, New Jersey). Thrombocytosis and leukocytosis can occur in the active phase of the disease. We report six patients with a long-standing history of ulcerative colitis who developed acute leukemia; five cases of which were of a specific subtype, acute promyelocytic leukemia.From 1974 through 1981, 227 patients newly diagnosed as having...References1. PERLMANNHAMMARSTRÖMLANGERCRANTZGUSTAFSSON PSRB. Antigen from colon germ-free rats and antibodies in human ulcerative colitis. Ann NY Acad Sci. 1965;124:377-94. CrossrefMedlineGoogle Scholar2. KOFFLERMINKOWITZROTHMANGARLOCK DSWJ. Immunocytochemical studies in ulcerative colitis and regional ileitis. Am J Pathol. 1962;41:733-40. MedlineGoogle Scholar3. KRAUSEMICHAELSSONJUHLIN VGL. Skin reactivity and phagocytic function of neutrophil leukocytes in Crohn's disease and ulcerative colitis. Scand J Gastroenterol. 1978; 13:71-5. CrossrefMedlineGoogle Scholar4. FABRYSACHARJANOWITZ TDH. Acute myelogenous leukemia in patients with ulcerative colitis. J Clin Gastroenterol. 1980;2:225-7. CrossrefMedlineGoogle Scholar5. VALCIVIESORODRIGUEZDREWINKO MVB. Clinical and morphological correlations in acute promyelocytic leukemia. Med Pediatr Oncol. 1975;1:37-50. CrossrefMedlineGoogle Scholar6. JANOWITZ H. Ulcerative colitis. In: BEESON PB, MCDERMOTT W, WYNGAARDEN JB, eds. Cecil Textbook of Medicine. 15th ed. Philadelphia: W. B. Saunders Co.; 1979: 1568-76. CrossrefGoogle Scholar7. JONESSALEEN MA. Acute promyelocytic leukemia: a review of the literature. Am J Med. 1978;65:673-7. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: JANET CUTTNER, M.D.Affiliations: Polly Annenberg Levee Hematology Center The Mount Sinai Hospital New York, New York. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byClustered incidence of adult acute promyelocytic leukemia in the vicinity of BaltimoreMalignant Tumors Arising in Inflammatory Bowel DiseaseMalignant Tumors Arising in Inflammatory Bowel DiseaseHematological malignancies in chronic inflammatory bowel diseases: report of five cases and review of the literatureJuvenile myelomonocytic leukemia in a child with Crohn diseaseCrohn's Disease and Acute Lymphoblastic Leukemia in A Two-Year-Old ChildIncreased Risk of Cancer in Ulcerative Colitis: A Population-Based Cohort StudyKnochenmark und myelogene NeoplasienEndoscopic diagnosis of lower intestinal lesions of leukaemia and malignant lymphomaRisk Factors and Distinguishing Features of Cancer in IBDChronic Granulocytic Leukemia in a Patient with Ankylosing Spondylitis and Ulcerative Colitis: An Interesting AssociationThe Association of Inflammatory Bowel Disease and Leukemia—Coincidence or Not?A case of combined primary biliary cirrhosis, ulcerative colitis and chronic myelocytic leukemiaExtracolonic malignancies in inflammatory bowel diseaseDevelopment of acute myelocytic leukemia in patients with Crohn's diseaseColorectal and extracolonic malignancy in ulcerative colitisInflammatory bowel disease and leukemiaAssociation of inflammatory bowel disease (IBD) with indolent soft-tissue sarcomas: Report of two cases and review of literatureExtraintestinal cancers in inflammatory bowel diseaseInflammatory bowel diseases and their relationship to malignancyEvidence for a 15; 17 translocation in every patient with acute promyelocytic leukemiaAdult Acute Nonlymphocytic LeukemiaMalignant Tumors Arising in Inflammatory Bowel Disease 1 December 1982Volume 97, Issue 6Page: 864-865KeywordsDrugsEtiologyHematology and oncologyHemolytic anemiaHemorrhageIron deficiency anemiaLeukocytosisThrombocytosisUlcerative colitis ePublished: 1 December 2008 Issue Published: 1 December 1982 PDF downloadLoading ...