SALT METABOLISM IN HYPERTENSION
Authors: J M WELLER, S W HOOBLER
Journal: Annals of Internal Medicine (1959)

Article1 January 1959SALT METABOLISM IN HYPERTENSIONJOHN M. WELLER, M.D., F.A.C.P., SIBLEY W. HOOBLER, M.D., F.A.C.P.JOHN M. WELLER, M.D., F.A.C.P., SIBLEY W. HOOBLER, M.D., F.A.C.P.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-50-1-106 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptIt is an established fact that sodium chloride metabolism is abnormal in essential hypertension. However, the exact role which the disordered salt metabolism plays in either the pathogenesis or the perpetuation of this disease is not clear. Both the distribution of sodium within the body and its elimination by the kidney are altered. It has been demonstrated that patients with essential hypertension have slightly elevated serum sodium concentrations.1, 2In some subjects there is an expansion of the total body sodium, and it has been postulated that this excess sodium is located intracellularly.3The arterial wall of both hypertensive patients...Bibliography1. HolleyElliottHolland HLHCCM: Serum sodium values in essential hypertension, Proc. Soc. Exper. Biol. and Med. 77: 561, 1951. CrossrefMedlineGoogle Scholar2. AlbertMoritaIseri DGFLT: Serum magnesium and plasma sodium levels in essential vascular hypertension, Circulation 17: 761, 1958. CrossrefMedlineGoogle Scholar3. Ross EJ: Total exchangeable sodium in hypertensive patients, Clin. Sc. 15: 81, 1956. MedlineGoogle Scholar4. TobianBinion LJT: Tissue cations and water in arterial hypertension, Circulation 5: 754, 1952. CrossrefMedlineGoogle Scholar5. TobianBinion LJ: Artery wall electrolytes in renal and DCA hypertension, J. Clin. Investigation 33: 1407, 1954. 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Author, Article, and Disclosure InformationAffiliations: Ann Arbor, Michigan*Presented at the Thirty-ninth Annual Session of The American College of Physicians, Atlantic City, New Jersey, April 29, 1958.From the Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, Michigan.†This work has been supported in part by grants from the Michigan Heart Association, American Heart Association, and the National Heart Institute, U. S. Department of Health, Education, and Welfare.Requests for reprints should be addressed to John M. Weller, M.D., Department of Internal Medicine, University Hospital, Ann Arbor, Michigan. 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SHAPIRO, M.D.Transmembrane gationic gradient and blood pressure regulation 1 January 1959Volume 50, Issue 1Page: 106-114KeywordsBlood plasmaExcretionHeartHypertensionKidneysNatriuretic peptidesPathogenesisSaltsSodiumSodium chloride ePublished: 1 December 2008 Issue Published: 1 January 1959 PDF downloadLoading ...