tbuckley/cabot-search huggingface dataset:
Abstract 3445: The role of the truncated product of the neuregulin 4 gene in cancer and normal tissues
Authors: Markella J. Alatsatianos, Edith Blackburn, William Gullick
Journal: Cancer Research (2014)

Abstract The Epidermal Growth Factor Receptor (EGFR) family consists of a group of four transmembrane proteins, EGFR, the Human Epidermal Growth Factor 2 (HER2), HER3 and HER4 that are each involved in cell-signalling. They are activated by ligands, which include the neuregulin (NRG) family of proteins. These proteins are produced as various splice variants from four genes, NRG1-4. Although NRG1 has been extensively investigated, not much is known about the other neuregulins. Thus far, the NRG4 gene has been found to encode five proteins, NRG4 A1, NRG4 A2, NRG4 B1, NRG4 B2 and NRG4 B3. NRG4s B1-3 are truncated structures, which either prematurely terminate as in NRG4s B1 and B2, or have an additional 21 amino acids as in NRG4 B3. Little is known about the structure and function of the NRG4 B3. Previous studies have suggested that it has a different disulphide bond arrangement than that of the other EGF-like ligands. In this study, we have surveyed the expression of NRG4 B3 in breast, lung and colorectal cancers, and found that it is expressed at variable levels. Nuclear magnetic resonance spectroscopy of re-folded NRG4 B3 suggests it has a largely unfolded structure very different from the typical EGF-like molecules. It also has distinct properties in that it is a weak agonist for HER4 signaling and inhibits rather than promotes cell motility in various model systems. Taken together, this suggests that it may have a distinct role in normal and malignant tissues differing in properties to typical EGF-like proteins. Citation Format: Markella J. Alatsatianos, Edith Blackburn, William Gullick. The role of the truncated product of the neuregulin 4 gene in cancer and normal tissues. [abstract]. In: Proceedings of the 105th Annual Meeting of the American Association for Cancer Research; 2014 Apr 5-9; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2014;74(19 Suppl):Abstract nr 3445. doi:10.1158/1538-7445.AM2014-3445
Press: To diet for
Authors: R. MacDonald
Journal: BMJ (2001)

Are the media to blame for eating disorders?

The media may peddle images that make women unhappy with their bodies, but they are not responsible for eating disorders. That's the view of Kenneth Dunn, professor of psychological development at Sydney University. Professor Dunn told a debate at the Maudsley Hospital this month: “The media causes profound dissatisfaction in the female population but does not cause anorexia nervosa.”

Arguing for the motion “This house believes that the media is to blame for eating disorders” was Melanie Katzman, a consultant psychologist from New York, and William Bose, a spokesman …
Addendum: IgE+ memory B cells and plasma cells generated through a germinal-center pathway
Authors: Oezcan Talay, Donghong Yan, Hans D Brightbill, Elizabeth E M Straney, Meijuan Zhou, Ena Ladi, Wyne P Lee, Jackson G Egen, Cary D Austin, Min Xu, Lawren C Wu
Journal: Nature Immunology (2013)
Screening for Family and Intimate Partner Violence: Recommendation Statement
Authors: U. S. Preventive Services Task Force
Journal: Annals of Internal Medicine (2004)

This statement summarizes the U.S. Preventive Services Task Force (USPSTF) recommendations on screening for family and intimate partner violence, based on the USPSTF's examination of evidence specific to family and intimate partner violence, and updates the 1996 recommendations on this topic. In 1996, the USPSTF found insufficient evidence to recommend for or against the use of specific instruments to detect domestic violence (a grade C recommendation, according to 1996 grade definitions). The USPSTF now uses an explicit process in which the balance of benefits and harms is determined exclusively by the quality and magnitude of the evidence. As a result, current letter grades are based on different criteria from those in 1996. The complete information on which this statement is based, including evidence tables and references, is available in the accompanying article in this issue and in the summary of the evidence and systematic evidence review on the USPSTF Web site (www.preventiveservices.ahrq.gov) and through the National Guideline Clearinghouse (www.guideline.gov). The USPSTF recommendation, the accompanying summary article, and the complete systematic evidence review are available through the USPSTF Web site (www.preventiveservices.ahrq.gov). The summary article and the USPSTF recommendation statement are available in print through the Agency for Healthcare Research and Quality Publications Clearinghouse (telephone, 800-358-9295; e-mail, ahrqpubs@ahrq.gov). *For a list of the members of the U.S. Preventive Services Task Force, see the Appendix.
Abstract 18650: Ninjurin1, a Novel Regulatory Factor of Pericytes to Interact With Endothelial Cells, Mediates the Circulation Recovery in the Hind Limb Ischemia
Authors: Motoki Matsuki, Jun-ichi Kawabe, Tatsuya Aonuma, Maki Kabara, Atsushi Yamauchi, Kohei Shimamura, Akiho Minoshima, Naofumi Takehara, Yukihiro Saito, Naoyuki Hasebe
Journal: Circulation (2014)

Background: Microvascular maturation/stabilization is crucial phenomenon for patho-physiological situations such as ischemic diseases. Vascular maturation/stabilization is regulated through the interaction between pericytes (PCs) and endothelial cells (ECs). In order to clarify the mechanisms for vascular maturation/stabilization, we detected a novel factor, which is involved in the interaction between PCs and ECs using capillary-derived PCs cell lines, and examined the role of this factor on angiogenesis. Methods and Results: We have established immortalized capillary-derived PCs from temperature sensitive SV40T-antigen-harboring mice. After GFP-expressing PCs were co-incubated with/without the sprouting EC tubes in 3D-gel, GFP-positive cells were collected by FACS and applied to microarray analysis. Ninjurin1 (nerve injured protein; Ninj1) have been selected among several candidate genes, of which expression levels in PCs were changed after interaction with sprouting EC tubes. When expression of Ninj1 i...
Predicted spirometric values for Romanian adults – A preliminary study
Authors: Laura Lihatchi, Diana Ionita
Journal: European Respiratory Journal (2011)

Background:  No populational study was made in Romania to determine predicted spirometric values.   Aims:  To analyze spirometric data measured in healthy volunteer adults. To compare spirometric values with predicted values calculated using European equations (Eur Respir J, 1983).   Subjects and methods:  Spirometry was performed in conformity with ATS/ERS criteria (2005) in healthy, nonsmoker adults without thoracic deformities. The best values for FVC and FEV1 were analyzed and compared with the predicted values.   Results:  53 subjects (37 women) were enrolled, mean age 30.7 years (22-47).  FVC values were 6.9% larger than the predicted values in the whole group. For 39 subjects (73.6%) measured FVC values were outside the 95-105% interval of FVC predicted values, the majority of measured values being larger than the predicted values (in 33 subjects).  FEV1 values were 4.1% larger than the predicted values in the whole group. For 31 subjects (58.5%) measured FEV1 values were outside the 95-105% interval of FEV1 predicted values.   Conclusions:  A significant number of healthy adults have had spirometric values outside the confidence interval of predicted values (European equations in use). A larger study is needed in subjects with different ages and heights to verify the data obtained in our study. The opportunity of determining specific predicted values in a large populational study is discussed, considering the necessary resources.
Abstract 17471: 3D Contrast-enhanced Ultrasound (CEUS) Imaging of Carotid Artery Plaques and Intra-plaque Angiogenesis
Authors: Venu Gourineni, Sandeep Saha, Kunlin Cao, Jing Jin, Aaron M Dentinger, David M Mills, Dirk R Padfield, Kirk D Wallace, Vijaya Reddy, Boris M Shur, Frank Yamout, Walter McCarthy, Robert March, Chad Jacobs, Adele Liuzzo, Marshall Goldin, Dan Adam, Steven Feinstein
Journal: Circulation (2014)

Introduction: Vulnerable plaque is marked by increased intra-plaque vascularity, hemorrhage and is associated with cerebrovascular (CV) events. Current use of 2D CEUS carotid imaging does not provide a true volumetric representation of the intra-plaque angiogenesis. Therefore, this is the first clinical trial using 3D CEUS to assess intra-plaque angiogenesis, in patients with clinically significant plaques prior to carotid endarterectomy (CEA). Methods: Data were acquired on 11 patients that were asked to participate in this pilot study prior to CEA. All patients had MR and/or CT angiogram as part of their standard care and all carotid artery plaque specimens were collected and sent for histologic evaluation. CEUS volumes were acquired using a GE LOGIQ E9, RSP6-16 4D probe and Optison. In order to assess plaque vulnerability, semi-automatic image analysis algorithms were developed to segment the lumen, plaque, and intra-plaque vascularity. Measurements derived from 3D CEUS images were validated against CT, MR, and histology. Results: Preliminary results from 3 patients were analyzed and lumen volumes were segmented from all available modalities (figure shows CEUS example). Lumen measurements of the CCA, ICA, and ECA from 3D CEUS were compared to MR or CT. High correlation is shown in the figure for these patients (R 2 =0.95). Further analysis of the 3D CEUS images demonstrates that we can identify intra-plaque vascularity (see segmentation from one patient). These CEUS results estimated an average cross-sectional vascular density of 7-11% in the plaque, matching histology estimates of 10% from a single slice. Conclusion: These results demonstrate that it is feasible to use 3D CEUS for quantitative, volumetric imaging of the carotid artery and intra-plaque angiogenesis in patients scheduled for CEA. Future work will extend this analysis to all patients and make a quantitative comparison of intra-plaque vascular density from 3D CEUS vs. multiple histology slices.
Angiotensin-Converting Enzyme Genotypes and Risk for Myocardial Infarction in Women 11This study was supported in part by grants from the Deseret Foundation, LDS Hospital, Salt Lake City, Utah and the National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland.
Authors: Jeffrey L Anderson, John F Carlquist, Gretchen J King, Linda Morrison, Matthew J Thomson, Erwin H Ludwig, Joseph B Muhlestein, Tami L Bair, Richard H Ward
Journal: Journal of the American College of Cardiology (1998)
Sleeping Giants: Emerging Roles for the Fat Cadherins in Health and Disease
Authors: Elham Sadeqzadeh, Charles E. de Bock, Rick F. Thorne
Journal: Medicinal Research Reviews (2013)

The vertebrate Fat cadherins comprise a small gene family of four members, Fat1-Fat4, all closely related in structure to Drosophila ft and ft2. Over the past decade, knock-out mouse studies, genetic manipulation, and large sequencing projects has aided our understanding of the function of vertebrate Fat cadherins in tissue development and disease. The majority of studies of this family have focused on Fat1, with evidence now showing it can bind enable (ENA)/Vasodilator-stimulated phosphoprotein (VASP), β-catenin and Atrophin proteins to influence cell polarity and motility; HOMER-1 and HOMER-3 proteins to regulate actin accumulation in neuronal synapses; and scribble to influence the Hippo signaling pathway. Fat2 and Fat3 can regulate cell migration in a tissue specific manner and Fat4 appears to influence both planar cell polarity and Hippo signaling recapitulating the activity of Drosophila ft. Knowledge about the exact downstream signaling pathways activated by each family member remains in its infancy, but it is becoming clearer that they have tissue specific and redundant roles in development and may be lost or gained in cancer. In this review, we summarize the recent progress on understanding the role of the Fat cadherin family, integrating the current knowledge of molecular interactions and tissue distributions, together with the accumulating evidence of their changed expression in human disease. The latter is now beginning to promote interest in these molecules as both biomarkers and new targets for therapeutic intervention.
Die Behandlung der rheumatischen Krankheiten.
Authors: W. Fehlow, M. Hirsch, W. Kempf, Arnold Zimmer
Journal: JAMA (1930)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Abstract 17944: Effects of School-Based Interventions on Body Mass Index in Children and Adolescents: a Systematic Overview and Meta-analysis
Authors: Jiyoon J Park, Randa Bakhet, Danica Karl, Fei Yuan, Eva Lonn
Journal: Circulation (2014)

Background: Childhood obesity is a major public health threat. Various school-based interventions (SBIs) to prevent obesity through physical activity and/or dietary modifications were implemented. However, the effectiveness of such SBIs remains unproven. Therefore, we conducted a meta-analysis of randomized controlled trials (RCTs) of SBIs. Methods: We searched for RCTs of SBIs published since 1990. To be eligible studies had to have an RCT design, to include children aged 6-18 years and SBIs were defined as non-pharmacological and non-surgical interventions carried out in a school setting with a minimum duration of 12 weeks. The primary outcome was change in body mass index (BMI. For each study the difference in the mean change in BMI between the intervention and the control groups was computed. The summary estimate for the difference in mean change in BMI and the 95% confidence interval (CI) was computed using a weighted inverse variance approach and a random- effects model. The I 2 statistic was used to test for heterogeneity. Results: Of 504 studies identified, 41 involving 42 430 participants met the inclusion criteria. SBIs varied greatly between studies by type, duration and delivery. In 10 RCTs the SBI focused on physical activity, in 6 on dietary modifications and in 25 on both physical activity and dietary modifications. SBIs duration ranged from 12 weeks to 4 years. There was no significant difference in mean BMI change between the intervention and the control groups (mean difference = -0.281kg/m 2 ; 95% CI -0.584 to 0.022), although there was significant heterogeneity between the RCTs’ findings (Figure). We found also no consistent impact on other measures of adiposity, physical activity patterns, dietary intakes and psychosocial health and wellbeing. Conclusions: SBIs had no substantial impact on BMI in children aged 6-18 years. Further research is needed to identify effective interventions to prevent childhood obesity.
Abstract 30: Medi3622, a monoclonal antibody to ADAM17, inhibits tumor growth by inhibiting EGFR- and non-EGFR-mediated pathways
Authors: Darrin Sabol, Jonathan RiosDoria, Jon Chesebrough, David Stewart, Kevin Schifferli, Raymond Rothstein, Ching Ching Leow, Jenny Heidbrink-Thompson, Li Cheng, Qun Du, Linda Xu, Xiaofang Jin, Ravinder Tammali, Chanshou Gao, Jay Friedman, Brandy Wilkinson, Melissa Damschroder, Andrew Pierce, MunMun Patnaik, Rong Zeng, Yuling Wu, Susan Spitz, Gabriel Robbie, Lorin Roskos, Robert Hollingsworth, David Tice, Emil Michelotti
Journal: Cancer Research (2015)

Abstract ADAM17 is the primary sheddase for HER pathway ligands. We report the discovery of a potent and specific ADAM17 inhibitory antibody, MEDI3622, which induces tumor regression or stasis in many EGFR-dependent tumor models. The inhibitory activity of MEDI3622 correlated with EGFR activity both in a series of tumor models across several indications as well as in a focused set of head and neck patient derived xenograft models. Cynomolgus monkey and rat PK/PD assays showed MEDI3622 inhibited TNFα shedding. Toxicity observed in cynomolgus monkey and rat was similar to EGFR inhibitor-induced rash. However, the antitumor activity of MEDI3622 was superior to that of EGFR/HER pathway inhibitors in OE21 head and neck and COLO205 colorectal xenograft models suggesting additional activity outside of the EGFR pathway. Combination of MEDI3622 and cetuximab in the OE21 model was additive and eradicated tumors. Proteomics analysis revealed novel ADAM17 substrates which function outside of the HER pathways and may contribute towards the antitumor activity of the monoclonal antibody. Citation Format: Darrin Sabol, Jonathan RiosDoria, Jon Chesebrough, David Stewart, Kevin Schifferli, Raymond Rothstein, Ching Ching Leow, Jenny Heidbrink-Thompson, Li Cheng, Qun Du, Linda Xu, Xiaofang Jin, Ravinder Tammali, Chanshou Gao, Jay Friedman, Brandy Wilkinson, Melissa Damschroder, Andrew Pierce, MunMun Patnaik, Rong Zeng, Yuling Wu, Susan Spitz, Gabriel Robbie, Lorin Roskos, Robert Hollingsworth, David Tice, Emil Michelotti. Medi3622, a monoclonal antibody to ADAM17, inhibits tumor growth by inhibiting EGFR- and non-EGFR-mediated pathways. [abstract]. In: Proceedings of the 106th Annual Meeting of the American Association for Cancer Research; 2015 Apr 18-22; Philadelphia, PA. Philadelphia (PA): AACR; Cancer Res 2015;75(15 Suppl):Abstract nr 30. doi:10.1158/1538-7445.AM2015-30
THE RELATION OF MEDICAL ZOOLOGY TO PUBLIC HEALTH PROBLEMS
Authors: R. W. Hegner
Journal: JAMA (1920)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Sixth Meeting of the European Association for Cancer Research
Authors: Karoly Lapis, George Weber
Journal: JNCI Journal of the National Cancer Institute (1981)

Journal Article Sixth Meeting of the European Association for Cancer Research Get access JNCI: Journal of the National Cancer Institute, Volume 66, Issue 3, March 1981, Page 609, https://doi.org/10.1093/jnci/66.3.609-e Published: 01 March 1981
Histopathological Technic Including a Discussion of Botanical Microtechnic.
Authors: Aram A Krajian, R. B. H. Gradwohl
Journal: JAMA (1952)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Heart Rate Variability
Authors: Conny M. A. van Ravenswaaij-Arts
Journal: Annals of Internal Medicine (1993)

Purpose: To present an overview of the applicability of heart rate variability measurements in medicine. Data Sources: During a 4-year period all new papers concerning heart rate variability were collected. A selection of the most recent publications in the presented research area was used for this review. Data Synthesis: The amount of short- and long-term variability in heart rate reflects the vagal and sympathetic function of the autonomic nervous system, respectively. Therefore heart rate variability can be used as a monitoring tool in clinical conditions with altered autonomic nervous system function. In postinfarction and diabetic patients, low heart rate variability is associated with an increased risk for sudden cardiac death. A sympathovagal imbalance is also detectable with heart rate variability analysis in coronary artery disease and essential hypertension. Besides diabetic neuropathy, in many other neurologic disorders, such as brain damage, the Guillain-Barre syndrome, and uremic neuropathy, heart rate variability analysis can provide insight into which division of the autonomic nervous system is most affected. Heart rate variability can be influenced by various groups of drugs, but it can also shed light on the mode of action of drugs. The protective effect of cardiovascular drugs in postinfarction patients has been investigated. Conclusions: Heart rate variability analysis is easily applicable in adult medicine, but physiologic influences such as age must be considered. The most important application is the surveillance of postinfarction and diabetic patients to prevent sudden cardiac death. With heart rate variability analysis, individual therapy adjustments to achieve the most favorable sympathetic-parasympathetic balance might be possible in the future.
Platelet Factor 4 and Other CXC Chemokines Support the Survival of Normal Hematopoietic Cells and Reduce the Chemosensitivity of Cells to Cytotoxic Agents
Authors: Zhong Chao Han, Min Lu, Junmin Li, Mai Defard, Bernadette Boval, Nicole Schlegel, Jacques P. Caen
Journal: Blood (1997)