tbuckley/cabot-search huggingface dataset:
Autologous Mesenchymal Stem Cells Foster Revascularization of Ischemic Limbs in Systemic Sclerosis
Authors: Serena Guiducci, Francesco Porta, Riccardo Saccardi, Stefano Guidi, Lidia Ibba-Manneschi, Mirko Manetti, Benedetta Mazzanti, Simone Dal Pozzo, Anna Franca Milia, Silvia Bellando-Randone, Irene Miniati, Ginevra Fiori, Rossana Fontana, Laura Amanzi, Francesca Braschi, Alberto Bosi, Marco Matucci-Cerinic
Journal: Annals of Internal Medicine (2010)

Background: Mesenchymal stem cells can differentiate into endothelial cells and participate in angiogenesis in adults. In experimental models of acute myocardial infarction, mesenchymal stem cells led to the recovery of cardiac function through the formation of a new vascular network. Objective: To describe treatment with intravenous infusions of expanded autologous mesenchymal stem cells in 1 patient with critical limb ischemia due to systemic sclerosis. Design: Case report. Setting: The rheumatology unit at the University of Florence, Florence, Italy. Patient: A woman, aged 34 years, with systemic sclerosis who developed acute gangrene of the upper and lower limbs. Intervention: 3 intravenous pulses of expanded autologous mesenchymal stem cells. Measurements: Angiography, skin histopathology, and immunohistochemistry. Results: Areas of necrotic skin were reduced after the first mesenchymal stem-cell infusion. After the third infusion, angiography showed revascularization of the patient's extremities. Skin section analysis revealed cell clusters with tubelike structures, and angiogenic factors were strongly expressed. Limitation: Causality cannot be established by a single case. Conclusion: In patients with systemic sclerosis who have severe peripheral ischemia, intravenous infusion of expanded autologous mesenchymal stem cells may foster the recovery of the vascular network, restore blood flow, and reduce skin necrosis. Primary Funding Source: Fondazione Cassa di Risparmio di Pistoia e Pescia (partial funding).
New suspension procedures aim to cut NHS disciplinary bill
Authors: Zosia Kmietowicz
Journal: BMJ (2005)

Disciplinary procedures for NHS doctors and dentists are being speeded up in a bid to cut the multimillion pound salary bill for suspended staff.

Under new rules that come into effect on 1 June, cases of suspension from NHS posts in England will have to be resolved in 13 weeks—19 weeks less than the present target time of 32 weeks. In addition, the right of consultants on the …
Early and 1-Year Clinical Outcome of Patients’ Evolving Non–Q-Wave Versus Q-Wave Myocardial Infarction After Thrombolysis
Authors: Frank V. Aguirre, Liwa T. Younis, Bernard R. Chaitman, Allan M. Ross, Robert P. McMahon, Morton J. Kern, Peter B. Berger, George Sopko, William J. Rogers, Leslee Shaw, Genell Knatterud, Eugene Braunwald
Journal: Circulation (1995)

Background There are few data comparing clinical outcome and potential indications for routine post–myocardial infarction cardiac catheterization and revascularization of patients who sustain a non–Q-wave versus Q-wave infarct after thrombolytic therapy. Methods and Results A secondary analysis of 2634 patients enrolled in the TIMI II trial with a first myocardial infarction was performed to determine 6-week and 1-year cardiac event rates and identify clinical and angiographic differences between the 1867 patients (70.9%) who evolved a Q-wave infarct and the 767 patients (29.1%) who sustained a non–Q-wave infarct after treatment with intravenous thrombolytic therapy. Male sex (85.3% versus 75.6%; P &lt;.001) and anterior wall infarcts (53.8% versus 43.7%; P &lt;.001) were more frequent in the Q-wave versus the non–Q-wave group. During recombinant tissue-type plasminogen activator (rTPA) infusion, a greater percentage of non–Q-wave patients (37.3% versus 23.5%; P =.001) had normalization of initial ST-segment elevation. Infarct-related artery patency (TIMI flow grade 2 or 3) ( P =.02), complete infarct-related artery reperfusion (TIMI 3 flow grade) ( P &lt;.001), and the percentage of patients with a predischarge resting left ventricular ejection fraction &gt;55% ( P &lt;.001) were greater in the non–Q-wave group. New congestive heart failure during hospitalization developed more frequently in Q-wave patients (18.9% versus 11.6%; P &lt;.001). After 42 days, the occurrences of reinfarction ( P =.76), death ( P =.76), and combined death or reinfarction ( P =.43) were similar in patients assigned to the invasive or conservative postlytic management strategy, regardless of infarct type. One-year mortality was 3.4% versus 4.4% for non–Q-wave versus Q-wave infarct type, respectively ( P =.25). Conclusions Angiographic and clinical differences were observed between patients who present with initial ST-segment elevation and evolve early non–Q-wave versus Q-wave myocardial infarcts after treatment with rTPA, heparin, and aspirin. Early mortality and adverse clinical cardiac events in these patients are not significantly different after a conservative compared with an invasive treatment strategy, regardless of whether the infarct type is non–Q wave or Q wave.
Potential and Pitfalls of e-Cigarettes—Reply
Authors: David B. Abrams
Journal: JAMA (2014)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Validation of the second-generation Olympus colonoscopy simulator for skills assessment
Authors: A. Haycock, P. Bassett, J. Bladen, S. Thomas-Gibson
Journal: Endoscopy (2009)

Simulators have potential value in providing objective evidence of technical skill for procedures within medicine. The aim of this study was to determine face and construct validity for the Olympus colonoscopy simulator and to establish which assessment measures map to clinical benchmarks of expertise.Thirty-four participants were recruited: 10 novices with no prior colonoscopy experience, 13 intermediate (trainee) endoscopists with fewer than 1000 previous colonoscopies, and 11 experienced endoscopists with more than 1000 previous colonoscopies. All participants completed three standardized cases on the simulator and experts gave feedback regarding the realism of the simulator. Forty metrics recorded automatically by the simulator were analyzed for their ability to distinguish between the groups.The simulator discriminated participants by experience level for 22 different parameters. Completion rates were lower for novices than for trainees and experts (37 % vs. 79 % and 88 % respectively, P < 0.001) and both novices and trainees took significantly longer to reach all major landmarks than the experts. Several technical aspects of competency were discriminatory; pushing with an embedded tip ( P = 0.03), correct use of the variable stiffness function ( P = 0.004), number of sigmoid N-loops ( P = 0.02); size of sigmoid N-loops ( P = 0.01), and time to remove alpha loops ( P = 0.004). Out of 10, experts rated the realism of movement at 6.4, force feedback at 6.6, looping at 6.6, and loop resolution at 6.8.The Olympus colonoscopy simulator has good face validity and excellent construct validity. It provides an objective assessment of colonoscopic skill on multiple measures and benchmarks have been set to allow its use as both a formative and a summative assessment tool.
Medical Research for Hire: The Political Economy of Pharmaceutical Clinical Trials
Authors: Michael Goodyear
Journal: JAMA (2009)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Theodore Inslee Jones
Authors: G. Stewart
Journal: BMJ (2011)

Theodore Inslee Jones (“Ted”) made his first visit to Scotland in 1941 as a pilot in 422 Night Fighter Squadron of the US Army Air Force. He returned to the United States to qualify in medicine at Cornell University and then to become a fellow of the American College of Surgeons, with appointments as an associate professor at the Medical School in Rochester, New York, and visiting surgeon at two teaching hospitals, and a private practice. He married Ann Kramer and had five children, four boys and a girl, and now four grandchildren.

Their vigorous and prosperous life style in New York State included sailing and rural pursuits. It was surprising when, from this enviable base and with Ann’s agreement, Ted decided to fulfil an earlier ambition dating from his wartime experience in Scotland to seek a simpler, more natural life as a general practitioner in a friendly community with his boat moored near by and a cottage hospital to maintain his link with surgery. So, in 1973, he set sail with three companions in his 35 foot yawl ARIES (a milestone in longitude) and crossed the Atlantic from Long Island to Falmouth in 33 days. His family followed by air, and they rented an apartment in Townhead Terrace, Paisley, Renfrewshire, a …
Advanced-Practice Nursing -- Good Medicine for Physicians?
Authors: M O Mundinger
Journal: New England Journal of Medicine (1994)

Health care reform has engendered many debates. One that has captured the attention of physicians, nurses, and policy makers is the relation, and perhaps the competition, between physicians and advanced-practice nurses. Advanced-practice nurses are registered nurses with specialty training, usually at the master's-degree level, in primary care (i.e., nurse practitioners and nurse-midwives) or acute care of inpatients (i.e., clinical nurse specialists). The practice of nurse practitioners has been evaluated since 1965, when the role was developed by Henry Silver, M.D., and Loretta Ford, R.N. When measures of diagnostic certainty, management competence, or comprehensiveness, quality, and cost are used, virtually every . . .
Internal Drainage of Pseudocyst of Pancreas
Authors: Allan J. Ryan, Thomas P. Murdock
Journal: New England Journal of Medicine (1953)

SINCE the first report of a successful anastomosis of a pseudocyst of the pancreas to the jejunum by Hahn1 in 1927, this procedure has apparently become the treatment of choice for many surgeons. Only Meyer,2 both of whose patients died of infection after operation, and Zieman3 (1949) express discouragement.The first successful applications of the Roux-Y principle to the operation of cystjejunostomy were reported almost simultaneously in 1948 by Gurwitz and Hurwitz,4 Migliaccio and Laurelli5 and Griesmann.6 Since then, according to Moore and Schumacher,7 there have been 9 additional cases in which the Roux-Y limb was successfully used, making a . . .
Hepatoerythropoietic porphyria: a missense mutation in the UROD gene is associated with mild disease and an unusual porphyrin excretion pattern
Authors: D.K.B. Armstrong, P.C. Sharpe, C.R. Chambers, S.D. Whatley, A.G. Roberts, G.H. Elder
Journal: British Journal of Dermatology (2004)

Journal Article Hepatoerythropoietic porphyria: a missense mutation in the UROD gene is associated with mild disease and an unusual porphyrin excretion pattern Get access D.K.B. Armstrong, D.K.B. Armstrong Departments of Dermatology and Clinical Biochemistry, Craigavon Area Hospital, Craigavon, Co Armagh, U.K Search for other works by this author on: Oxford Academic Google Scholar P.C. Sharpe, P.C. Sharpe Departments of Dermatology and Clinical Biochemistry, Craigavon Area Hospital, Craigavon, Co Armagh, U.K Search for other works by this author on: Oxford Academic Google Scholar C.R. Chambers, C.R. Chambers Departments of Dermatology and Clinical Biochemistry, Craigavon Area Hospital, Craigavon, Co Armagh, U.K Search for other works by this author on: Oxford Academic Google Scholar S.D. Whatley, S.D. Whatley Department of Medical Biochemistry and Immunology, University Hospital of Wales and University of Wales College of Medicine, Heath Park, Cardiff CF14 4XN, U.K Search for other works by this author on: Oxford Academic Google Scholar A.G. Roberts, A.G. Roberts Department of Medical Biochemistry and Immunology, University Hospital of Wales and University of Wales College of Medicine, Heath Park, Cardiff CF14 4XN, U.K Search for other works by this author on: Oxford Academic Google Scholar G.H. Elder G.H. Elder Department of Medical Biochemistry and Immunology, University Hospital of Wales and University of Wales College of Medicine, Heath Park, Cardiff CF14 4XN, U.K G. H. Elder. E‐mail: ghelder@trillium.fsworld.ac.uk Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 151, Issue 4, 1 October 2004, Pages 920–923, https://doi.org/10.1111/j.1365-2133.2004.06101.x Published: 01 October 2004 Article history Accepted: 16 February 2004 Published: 01 October 2004
An exo-cell assay for examining real-time γ-secretase activity and inhibition
Authors: Christopher C Shelton, Yuan Tian, Mark G Frattini, Yue-Ming Li
Journal: Molecular Neurodegeneration (2009)

gamma-Secretase is an aspartyl protease that cleaves multiple substrates that are involved in broad biological processes ranging from stem cell development to neurodegeneration. The investigation of gamma-secretase has been limited by currently available assays that require genetic or biochemical manipulation in the form of substrate transfection or membrane preparation. Here we report an exo-cell assay that is capable of characterizing gamma-secretase activity in any cellular system without limitation. Using a highly active, recombinant substrate this assay can quickly and easily ascertain the status of gamma-secretase activity in cell systems and patient samples. We have applied this method to determine the activity of gamma-secretase in primary cell samples where transfection and/or membrane isolation are not viable options. Importantly, it allows for the detection of real time gamma-secretase activity after inhibitor or drug treatment. The application of this assay to determine the role of gamma-secretase in physiological and pathological conditions will greatly facilitate our characterization of this complex protease and help in the development and evaluation of gamma-secretase-targeted therapies in Alzheimer's disease or a variety of neoplasms.
The ryanodine receptor channel as a molecular motif in atrial fibrillation: pathophysiological and therapeutic implications
Authors: D. Dobrev, N. Voigt, X. H. T. Wehrens
Journal: Cardiovascular Research (2010)

Atrial fibrillation (AF) is the most common cardiac arrhythmia and is associated with substantial morbidity and mortality. It causes profound changes in sarcoplasmic reticulum (SR) Ca2+ homeostasis, including ryanodine receptor channel dysfunction and diastolic SR Ca2+ leak, which might contribute to both decreased contractile function and increased propensity to atrial arrhythmias. In this review, we will focus on the molecular basis of ryanodine receptor channel dysfunction and enhanced diastolic SR Ca2+ leak in AF. The potential relevance of increased incidence of spontaneous SR Ca2+ release for both AF induction and/or maintenance and the development of novel mechanism-based therapeutic approaches will be discussed.
Symptoms in Vietnam Veterans Exposed to Agent Orange
Authors: Gilbert Bogen
Journal: JAMA (1979)

<h3>To the Editor.—</h3> Agent Orange is an herbicide containing equal parts of 2,4-dichlorophenoxyacetic acid and 2,4,5-trichlorophenoxyacetic acid. It was used extensively in Vietnam as a defoliant. A toxic contaminant is dioxin, 2,3,7,8 tetrachlorodibenzo-<i>p</i>-dioxin. A ten-month study of 78 Vietnam veterans who claimed exposure to Agent Orange yielded many findings: 85% of the men experienced a rash that was resistant to treatment. Using immunofluorescence in one patient, a skin biopsy specimen showed intraepithelial and intercellular IgA, IgG, and IgM. In 53% of the patients, the rash was aggravated by sunlight. Joint pain occurred in 71%, stiffness in 59%, and swelling in 45%. Hypersomnolence occurred in 44% of the men and extreme fatigue in 80%. Sinus bradycardia and premature ventricular contractions were not infrequent. Persistent neurological complaints were tingling (55%), numbness (60%), dizziness (69%), headache (35%), and autonomic dyscontrol (18%). Severe psychiatric manifestations were depression (73%), suicidal attempts (8%), and
Asthma in Children
Authors: Francis M. Rackemann, Mary C. Edwards
Journal: New England Journal of Medicine (1952)

CONTINUED studies of asthma in children enable us to evaluate a concept previously stated, that "When asthma begins before age 30, the cause is allergy unless proved otherwise; but when asthma begins after age 40, the cause is not allergy unless proved otherwise."1 A long-term follow-up study of asthma in children should result in a better understanding of clinical allergy.There are many questions to be answered. "How often do children outgrow their asthma?" and "What will happen to my child?" are the routine questions, but others are important also. Do the original cause and type of the asthma affect . . .
EARLY PCI AFTER THROMBOLYSIS VERSUS STANDARD THERAPY IN STEMI PATIENTS: A CUMULATIVE META-ANALYSIS
Authors: Federico Piscione, Warren J. Cantor, Francisco Fernandez-Aviles, Sigrun Halvorsen, Michel Le-May, Paul W. Armstrong, Scheller Bruno, Shaun G. Goodman, Konstantinos Dimopoulos, Francesco Borgia, Carlo Di Mario
Journal: Journal of the American College of Cardiology (2010)
Use by general practitioners of obstetric beds in a consultant unit: a further report.
Authors: K L Oldershaw, J M Brudenell
Journal: BMJ (1975)

Of 1,700 women booked for delivery by general practitioner obstetricians in a consultant unit, 1,399 had uncomplicated deliveries and the co-operation between practitioner and consultant was an obvious advantage for the 257 who were transferred completely to consultant care during pregnancy, labour, or puerperium. The scheme, which started in 1964, has enabled general practitioners to continue to give complete obstetric care to their patients. The number of participating practitioners has, however, declined from 80 to 16 indicating that many preferred to concentrate on antenatal work.
Immediate effects of diastolic loading variations on the left ventricular inotropic state in open chest dogs
Authors: P. SCHIERECK, P. J M KIL, E. L DE BEER
Journal: Cardiovascular Research (1986)

The influence of left ventricular filling and variations in end diastolic volume on cardiac performance was studied in the intact dog heart. Left ventricular filling volumes and stroke volumes were calculated on a beat to beat basis from measurements of natural mitral inflow and aortic outflow obtained by electromagnetic flow sensors. Instantaneous controlled modifications of end diastolic volume were performed through a cannula situated in the left ventricle and connected to a pump system outside the dog. This system enabled controlled increases or decreases of the end diastolic volume at any prechosen moment during the diastolic pause. Absolute volume variations in end diastolic volume and end systolic volumes could be calculated by combining the integrated flow signals from different consecutive beats. Left ventricular performance was evaluated in terms of end systolic volume and end systolic pressure variations. When the diastolic volume was abruptly increased by the pump system, natural mitral inflow decreased but end diastolic volume increased. The effect on diastolic pressure was dependent on the variation in filling rate, the amplitude of the infusion, the moment at which the infusion was started, and the diastolic pressure at the start of the infusion. Also stroke volume, maximal systolic pressure (PMAX), end systolic pressure, and end diastolic volume increased. The increased systolic performance was attributed to the increased end diastolic volume as expected according to Starling's law. When end diastolic volume was rapidly decreased during diastole by the pump, natural filling volumes increased to compensate for the volume loss by the pump. End diastolic volume was, however, smaller indicating that full compensation was not achieved. Evaluation of ventricular performance in terms of end systolic pressure and end systolic volume showed a decreased end systolic pressure and increased end systolic volume compared with the control values. The effect of a pump withdrawal was 1.62(0.38) times larger than could be explained on the basis of Starling's law. After the infusion of adrenaline the intrinsic depression disappeared and the influence of the volume withdrawal on cardiac performance was as expected from the Starling mechanism.