tbuckley/cabot-search huggingface dataset:
Hands That Held Other Hands
Authors: V M Kreng
Journal: JAMA (2000)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Virtual Reality Training for Carotid Stenting—Reply
Authors: Anthony G. Gallagher, Christopher U. Cates
Journal: JAMA (2005)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
CONSORT extension for reporting N-of-1 trials (CENT) 2015 Statement
Authors: S. Vohra, L. Shamseer, M. Sampson, C. Bukutu, C. H. Schmid, R. Tate, J. Nikles, D. R. Zucker, R. Kravitz, G. Guyatt, D. G. Altman, D. Moher
Journal: BMJ (2015)

N-of-1 trials provide a mechanism for making evidence based treatment decisions for an individual patient. They use key methodological elements of group clinical trials to evaluate treatment effectiveness in a single patient, for situations that cannot always accommodate large scale trials: rare diseases, comorbid conditions, or in patients using concurrent therapies. Improvement in the reporting and clarity of methods and findings in N-of-1 trials is essential for reader to gauge the validity of trials and to replicate successful findings. A CONSORT extension for N-of-1 trials (CENT 2015) provides guidance on the reporting of individual and series of N-of-1 trials. CENT provides additional guidance for 14 of the 25 items of the CONSORT 2010 checklist and recommends a diagram for depicting an individual N-of-1 trial and modifies the CONSORT flow diagram to address the flow of a series of N-of-1 trials. The rationale, development process, and CENT 2015 checklist and diagrams are reported in this document.
Health Care Needs Assessment: The Epidemiologically Based Needs Assessment Reviews
Authors: Andrew Stevens
Journal: BMJ (1994)

Vol 1: Prostate hernia cataract dementia psychiatric disorders alcohol drugs learning disabilities family planning community child health. Vol 2: Diabetes mellitus renal disease stroke lower respiratory disease coronary heart disease colorectal cancer lung cancer hip replacements' knee replacements cataract surgery hernia repair varicose veins.
Abstract A18: Genome-wide methylation profiling to identify potential epigenetic biomarkers associated with response to sunitinib in metastatic renal cell cancer patients (pts)
Authors: Jenny Kim, Mariette Labots, Henk Verheul, Michael Carducci, Shahnaz Begum, George Netto, Mohammad Hoque
Journal: Clinical Cancer Research (2015)

Abstract Background: Sunitiinib is a vascular endothelial growth factor receptor tyrosine kinase inhibitor (VEGFR TKI) that is widely used in the front line setting for the treatment of advanced renal cell cancer. As with other targeted agents, there is a significant heterogeneity in the clinical response to sunintib and a biomarker which would predict patients' response up front would be an invaluable tool in the clinical management of patients (pts) afflicted with this disease. In this regard, whole genome methylation array was performed between sunitinib responders and nonresponders to identify differentially methylated genes between these two subsets of pts. Methods: mRCC pts. who received sunitinib therapy with available frozen nephrectomy tissues and clinical data were identified. Responders (RES) were identified as patients with progression free survival (PFS)of &amp;gt;11 months (mos) and nonresponders (NRES) as those with PFS &amp;lt;3 mos. Whole genome methylation array was performed using Infinium Humanmethylation450 BeadChip Kit. The statistical analysis performed was based on one-way ANOVA and an empirical Bayes approach was used to moderate standard errors. The QC plots showed that all arrays were fine and successful. Results: Thirteen pts treated with sunitinib for mRCC with available frozen nephrectomy tissues as well as clinical data were identified. Five were selected for each RES and NRES cohort as described above. Three pts had PFS that ranged between 3-11 mos (INT). All pts. In RES had clear cell subtype. Two of the NRES group were of non-clear cell type. For RES vs. NRES, one genomic location, DENND2D, was significantly hypermethylated in the RES group with a false discovery rate (FDR) of &amp;lt;10%. For RES+INT vs NRES, DENND2D hypermethylation was also seen in the RES+INT group but 4 other genes (TTYH3, TRAPPC12, HLA-DRB6 and cg15042082) were shown to be hypermethylated in the NRES group, also with a FDR&amp;lt;10%. Conclusion: In this study, DENND2D was significantly hypermethylated in sunitinib RES vs. NRES in mRCC pts. Technical and clinical validation of DENND2D and the other 4 differentially methylated genes are planned as is immunohistochemistry study of DENND2D to evaluate downstream effects of methylation. Citation Format: Jenny Kim, Mariette Labots, Henk Verheul, Michael Carducci, Shahnaz Begum, George Netto, Mohammad Hoque. Genome-wide methylation profiling to identify potential epigenetic biomarkers associated with response to sunitinib in metastatic renal cell cancer patients (pts). [abstract]. In: Proceedings of the AACR Precision Medicine Series: Drug Sensitivity and Resistance: Improving Cancer Therapy; Jun 18-21, 2014; Orlando, FL. Philadelphia (PA): AACR; Clin Cancer Res 2015;21(4 Suppl): Abstract nr A18.
Abstract 20119: Incidence and Predictors of Left Ventricular Thrombus in ST Elevation Myocardial Infarction
Authors: Adam Driesman, Omar Hyder, Chris Lang, Jinnette Abbott
Journal: Circulation (2014)

Introduction: Anticoagulation with coumadin is often employed after anterior ST-segment elevation myocardial infarction (STEMI) complicated by left ventricular (LV) dysfunction to prevent LV thrombus and cardioembolic events. However, the combination of dual antiplatelet therapy used for coronary stents and coumadin has been repeatedly shown to have a high incidence of bleeding. The current guidelines give coumadin a class II recommendation and support an individualized approach to treatment. Hypothesis: Determining the incidence and predictors of LV thrombus in a contemporary STEMI population at high risk for LV thrombus may assist in clinical decision making. Methods: Anterior STEMI patients at our institution between 2006 and 2013 treated with primary percutaneous intervention (PCI) that had an echocardiogram performed within 1 week and an ejection fraction of less than 40% or less than 50% with anterior apical akinesis were retrospectively identified. 687 patients with anterior STEMI were screened and 310 met inclusion. Demographic, clinical, and angiographic data was extracted from the medical record. Patients were categorized in 2 groups according to echocardiographic findings (no LV thrombus or probable/definite LV thrombus). The groups were compared by chi squared or T-test where appropriate. Logistic regression analysis was performed. Results: The mean age of the study population was 61.8% and 71.5% were male. The incidence of LV thrombus was 15% (n=263 no thrombus; n=47 probable/definite thrombus). Patients with LV thrombus were less likely to have hyperlipidemia, and more likely to have post procedure TIMI 0-1 flow and no stent use compared to patient with no LV thrombus. After adjustment, variables associated with LV thrombus risk were cardiac arrest (OR 4.06, 1.3-12.7), unfractionated heparin post PCI (2.43, 1.16-5.1), and stent use (DES 0.22, .06-.77, BMS 0.23 .07-.75, compared to balloon angioplasty). Conclusions: The incidence of LV thrombus in at risk STEMI patients remains high in contemporary practice. Development of a clinical risk score is limited by the lack of a sufficient number of predictive variables. Further investigation is needed to determine the optimal anticoagulation strategy in these patients.
Abstract 5913: Effect of Exercise training on Myocardial Perfusion, Function and Dyssynchrony, in Heart Failure Patients: A Sub-Study of the HF-ACTION Trial
Authors: Salvador Borges-Neto, Ami E Iskandrian, David J Whellan, Christopher M O'Connor, Stephen J Ellis, Robert Pagnanelli, Sharon Settles, Andrew Kao, Khaled Abdul-Nour, William Kraus, Greg Ewald, Dalane Kitzman
Journal: Circulation (2008)
Electroconvulsive therapy in Massachusetts
Authors: M J Mills, D T Pearsall, J A Yesavage, C Salzman
Journal: American Journal of Psychiatry (1984)

A study of the use of electroconvulsive therapy in Massachusetts shows that between 1974 and 1980 ECT use decreased significantly in both public- and private-sector hospitals. This decline was particularly pronounced in public-sector hospitals. The average age of ECT-treated patients rose during the period; women received ECT more often than men; and bilateral ECT remained in more frequent use. Though ECT was most frequently prescribed for major depression, about 20% of those receiving it were diagnosed as having a dysthymic disorder. State regulation and advances in psychiatric treatment may partially explain the decrease in ECT use.
THE REDUNDANT DUODENUM: CLINICAL SIGNIFICANCE
Authors: Theodore H. Morrison, Maurice Feldman
Journal: Annals of Internal Medicine (1934)

Article1 March 1934THE REDUNDANT DUODENUM: CLINICAL SIGNIFICANCETHEODORE H. MORRISON, M.D., F.A.C.P., MAURICE FELDMAN, M.D.THEODORE H. MORRISON, M.D., F.A.C.P.Search for more papers by this author, MAURICE FELDMAN, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-7-9-1126 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptAlthough anomalies of the duodenum are occasionally observed in the routine roentgenological examination of the gastrointestinal tract, little attention has been paid to them clinically. With the development of roentgenologic technic in gastroenterology, more of these conditions are being discovered and as a consequence their clinical significance is becoming recognized. Abnormalities of the duodenum are frequently overlooked during an ordinary barium meal study principally on account of the fact that the examiner concentrates his attention on the first part of the duodenum or cap. It is quite probable that, were the entire duodenum studied with the same meticulous care, many...References1. FELDMAN M: Redundant duodenum, Am. Jr. Med. Sci., 1933, clxxxvi, 198-202. CrossrefGoogle Scholar2. CASTRONOVO E: Intorno ad alcune malformazioni congenite del duodeno considerate nei loro rapporti con la clinica, Radiol. med., 1927, xiv, 1077-1099. Google Scholar3. DUVALROUXBÉCLÈRE PJCH: The duodenum; medical, radiologic and surgical studies, 1928, C. V. Mosby Co., St. Louis, page 20. Google Scholar4. DALL'ACQUA V: Gli aspetti radiologici del duodeno mobile, Radiol. med., 1930, xvii, 781-802. Google Scholar5. KELLOGG EL: Abnormalities in the shape and position of the duodenum, Am. Jr. Surg., 1931, xii, 462-465. CrossrefGoogle Scholar6. QUÉNUJACQUELIN JC: Des déformations sus-mésocoliques en "M" du duodénum et de leurs stades évolutifs, 7 observations, Arch. d. mal. de l'app. digestif, 1932, xxii, 601-624. Google Scholar7. BRDICZKA JC: Abnorme Schleifenform der pars superior Duodeni und ihre differentialdiagnostische Bedeutung, Fortschr. a. d. Geb. d. Rontgenstrahlen, 1931, xliii, 222-225. Google Scholar8. TARTAGLI D: La morfologia duodenale sotto il rispetto anatomoradiologico, Radiol. med., 1931, xviii, 289-308. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Baltimore, Maryland*Read at the meeting of the American Gastro-Enterological Association in Washington, D. C., May 10, 1933.From the Gastro-Enterological Clinic of the Department of Medicine, University of Maryland, Baltimore, Md. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 March 1934Volume 7, Issue 9Page: 1126-1134KeywordsAttentionDuodenumGastroenterology and hepatologyGastrointestinal tract ePublished: 1 December 2008 Issue Published: 1 March 1934 PDF downloadLoading ...
Interventions for the pain of topical photodynamic therapy
Authors: R.S. Dawe
Journal: British Journal of Dermatology (2015)

ORIGINAL ARTICLE, p 192 Pain during the illumination phase of cutaneous topical photodynamic therapy (PDT) can be a problem. Most dermatologists occasionally see patients with lesions that would ideally be treated with PDT who decline because they have had PDT before and are unwilling to risk experiencing this type of pain again. PDT‐induced pain is only loosely associated with the amount of fluorescence. There must be factors other than variation in the amount of protoporphrin IX formed from the pro‐drug to explain why pain is a major problem for some and not for others. Although some factors, including skin area to be treated, diagnosis and site,1 2 are associated with amount of pain we still cannot predict for the individual whether pain will be an important problem or not. Various measures are often used to try to help with PDT‐induced pain, including distraction methods and forced cold air devices. Topical anaesthetics have not been shown to be helpful,3 4 nor has topical morphine helped.5 Large volumes of infiltrative local anaesthetic can be useful;6 7 ‘ordinary’ subcutaneous infiltrative anaesthetics have not been well studied. The rate of illumination is a factor, with portable illumination devices that allow doses to be given over longer times and the use of daylight, as a relatively low output source, causing less pain than conventional PDT.8 9
Abstract 11471: Peripheral Arterial Disease and Risk of Atrial Fibrillation and Stroke: The Multi-Ethnic Study of Atherosclerosis
Authors: Wesley T O’Neal, Jimmy T Efird, Saman Nazarian, Alvaro Alonso, Susan R Heckbert, Elsayed Z Soliman
Journal: Circulation (2014)

Introduction: Peripheral arterial disease (PAD) shares several risk factors with atrial fibrillation (AF) and persons with PAD have an increased risk of stroke. It is unclear if PAD is associated with an increased risk for AF and whether such an association explains the increased risk of stroke associated with PAD. Methods: We examined the association between PAD, as measured by the ankle-brachial index (ABI), and incident AF and incident stroke, separately, in 6,568 participants (mean age 62 ± 10; 53% women; 62% non-white) from the Multi-Ethnic Study of Atherosclerosis (MESA). ABI values &lt;1.0 or &gt;1.4 defined PAD in this analysis. Participants were free of baseline clinical cardiovascular disease and AF. AF was ascertained by review of hospital discharge records and from Medicare claims data until December 31, 2010. An independent adjudication committee ascertained stroke events. Cox regression was used to compute hazard ratios (HR) and 95% confidence intervals (95%CI) for the association between PAD and AF and stroke. Results: A total of 774 (12%) participants had baseline PAD. Over a median follow-up of 8.5 years, 301 (4.6%) participants developed AF and 140 (2.1%) developed stroke. In a model adjusted for socio-demographics, cardiovascular risk factors, and potential confounders, PAD was associated with an increased risk of AF (HR=1.5, 95%CI=1.1, 2.0). In a similar model, PAD was associated with incident stroke (HR=1.7, 95%CI=1.1, 2.5) and the magnitude of risk was not different after inclusion of AF as a time-dependent covariate (HR=1.7, 95%CI=1.1, 2.5). Similar results were obtained in subgroup analyses stratified by age, sex, and race/ethnicity. Conclusions: PAD is independently associated with an increased risk of AF and stroke in the MESA study. The relationship between PAD and stroke is not mediated by AF.
Abstract 19087: Endogenous and Exogenous Estrogen Exposure have Synergistic Effects on Mid-life Electrocardiographic PR Interval among Women: the Women’s Health Initiative Hormone Therapy Trial
Authors: Nisha I Parikh, Kristopher Kapphahn, Haley Hedlin, Jeffrey E Olgin, Matthew A Allison, Kelli K Ryckman, Marco V Perez, Molly E Waring, Barbara V Howard
Journal: Circulation (2014)

Introduction:  Prior data demonstrates that oophorectomized mice have shorter atrioventricular conduction/ PR and Atrio-His intervals compared to oophorectomized mice receiving exogenous estrogen. We hypothesized that endogenous estrogen exposure from cumulative pregnancies and reproductive period duration would relate to long-term differences in the PR interval and these effects would be modified by exogenous hormone therapy use and hysterectomy status (a proxy for unopposed estrogen usage in humans).   Methods:  We studied women free of prevalent cardiovascular disease in the Women’s Health Initiative Hormone Trial. We employed linear regression analysis to relate number of pregnancies and reproductive duration (time from menarche to menopause) with millisecond (ms) changes in PR interval on enrollment electrocardiogram. Multivariable models were adjusted for age, BMI, hypertension, diabetes, income, education, race, region of US, prior breastfeeding, antianxiety medications, antidepressants, lipid medication, and duration. Models were tested for effect modification by categories of prior hormone therapy use and hysterectomy.   Results:  Among 40,687 women [mean age 62.36 (SD:6.9) years], number of pregnancies was not related to increased PR interval (p value=0.12). Reproductive period duration was associated with PR interval (p   Conclusions:  Our findings suggest that a combination of endogenous and exogenous estrogen exposure have synergistic effects on PR interval in post-menopausal women.
Intelligence, Heredity, and Environment, by Ed Robert J Sternberg, Elena Grigorenko
Authors: S. W G Derbyshire
Journal: BMJ (1998)

Ed Robert J Sternberg, Elena Grigorenko Cambridge University Press, £24.95, pp 608 ISBN 0 521 46904 X

Few scientific discussions generate so much heat as those regarding intelligence. Argument rages as to whether there is a genetic influence over IQ and whether IQ is in turn related to intelligence. The similarity of IQ in twins reared apart certainly supports the view that genes have influence. Thomas Bouchard (chapter 5) reports five studies of identical twins who were reared apart and gives the weighted average correlation as 0.75, suggesting that a massive 75% of the variance in the twins' IQ can be related to their shared genes. Adoption studies suggest a more modest, but still hugely important, …
Teaching and Evaluating Students' Professionalism in US Medical Schools, 2002-2003RESEARCH LETTERS
Authors: Audiey Kao, Michelle Lim, Jeremy Spevick, Barbara Barzansky
Journal: JAMA (2003)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Abstract 13591: Durability of S.M.A.R.T. ControlTM Stent for Superficial Femoral Artery, J-SMART registry
Authors: Kenji Suzuki, Naoto Inoue, Taiichiro Meguro, Osamu Iida, Masaaki Uematsu, Shinsuke Nanto, Keisuke Hirano, Toshiya Muramatsu, Yoshimitsu Soga, Hiroyoshi Yokoi, Masakiyo Nobuyoshi
Journal: Circulation (2010)

Backgrounds: Stent deployment for superficial femoral artery (SFA) is still controversial. Although some published data reported efficacy of nitinol stent for long (≥10cm) SFA under appropriate med...