GASTRIC SECRETION AS INFLUENCED BY RAUWOLFIA ALKALOIDS
Authors: E M SCHNEIDER, M L CLARK
Journal: Annals of Internal Medicine (1957)

Article1 October 1957GASTRIC SECRETION AS INFLUENCED BY RAUWOLFIA ALKALOIDSEDWARD M. SCHNEIDER, M.D., MERVIN L. CLARK, M.D.EDWARD M. SCHNEIDER, M.D.Search for more papers by this author, MERVIN L. CLARK, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-47-4-640 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptRauwolfia and its various alkaloids have been recommended in the treatment of gastrointestinal syndromes because of their tranquilizing effects. But their stimulating effects on gastric secretion have made it difficult to determine the indications for their use.I. Studies with Intravenous Reserpine: The methods used in these studies have been previously reported.1, 2 Briefly, all subjects were studied after an overnight fast. A Levin tube was placed in the stomach and in every instancebaseline determinations of gastric acid were made over a 30- to 90-minute period prior to the administration of any agent, placebo or otherwise.a. Figure 1...Bibliography1. ClarkSchneider MLEM: The effect of intravenous reserpine on gastric acidity in man, Gastroenterology 29: 877, 1956. CrossrefGoogle Scholar2. SchneiderClark EMML: Hyperchlorhydria induced by intravenous reserpine: response to various therapeutic agents, Am. J. Digest. Dis. 1: 22, 1956. CrossrefMedlineGoogle Scholar3. AllenBarkerHinesKraleShickGiffordEstes EVNWEAWFRMRWJE: Medical treatment of essential hypertension, Proc. Staff Meet., Mayo Clin. 29: 459, 1954. MedlineGoogle Scholar4. BarrettRutledgeRogie WERAB: The action of Serpasil on gastrointestinal motility and secretion, Federation Proc. (Part I) 13: 334, 1954. Google Scholar5. MoorePierceDennison RBWFAD: The story of reserpine, J. Indiana M. A. 47: 853, 1954. Google Scholar6. Bein HJ: Zur Pharmakologie des Reserpin, eines neuen Alkaloids aus Rauwolfia serpentina Benth, Experentia 9: 107, 1953. CrossrefMedlineGoogle Scholar7. Wilkins RW: Clinical usage of Rauwolfia alkaloids including reserpine (Serpasil), Ann. New York Acad. Sc. 59: 36, 1954. CrossrefMedlineGoogle Scholar8. Winsor T: Human pharmacology of reserpine, Ann. New York Acad. Sc. 59: 61, 1954. CrossrefMedlineGoogle Scholar9. KirsnerFord JBH: The effect of reserpine upon basal gastric secretion in man, Arch. Int. Med. 99: 390, 1957. CrossrefGoogle Scholar10. PletscherShoreBrodie APABB: Serotonin release as a possible mechanism of reserpine action, Science 122: 374, 1955. CrossrefMedlineGoogle Scholar11. ShoreSilverBrodie PASLBB: Interaction of reserpine, serotonin, and lysergic acid diethylamide in brain, Science 122: 374, 1955. CrossrefMedlineGoogle Scholar12. BorgesBessman FJSP: Serotonin, Editorial, Ann. Int. Med. 46: 425, 1957. LinkGoogle Scholar13. HussarBruno AEE: Acute duodenal ulcer associated with reserpine therapy, Gastroenterology 31: 500, 1956. CrossrefMedlineGoogle Scholar14. DillonSwain DJM: Gastrointestinal hemorrhage as a complication of reserpine administration: report of two cases, Am. J. Psychiat. 113: 462, 1956. CrossrefMedlineGoogle Scholar15. WoffordCummins JDAJ: Hemorrhage from duodenal ulcer during the administration of reserpine, New England J. Med. 255: 1193, 1956. CrossrefMedlineGoogle Scholar16. Bucher GR: Uropepsin: a review of the literature and report of some experimental findings, Gastroenterology 8: 627, 1947. MedlineGoogle Scholar17. Anson ML: The estimation of pepsin and trypsin, papain and cathepsin with hemoglobin, J. Gen. Physiol. 22: 79, 1939. CrossrefGoogle Scholar18. GoodmanSandovalHalsted RDEJA: Observations on some of the technical and clinical factors influencing the determination of uropepsin excretion in man, J. Lab. and Clin. Med. 40: 872, 1952. MedlineGoogle Scholar19. CumminsBalfour JFDC: Effect of Rauwolfia alkaloids on the excretion of uropepsin in the human, J. A. M. A. 161: 864, 1956. CrossrefMedlineGoogle Scholar20. HagansDoeringAshleyClarkWolf JACRFWMLS: The therapeutic experiment: observations on the meaning of controls on biologic variation resulting from the treatment situation, J. Lab. and Clin. Med. 49: 282, 1957. MedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: *From the Symposium on Gastroduodenal Ulcer, presented at the Thirty-eighth Annual Session of The American College of Physicians, Boston, Massachusetts, April 11, 1957.From the Department of Medicine, University of Oklahoma School of Medicine, and the Veterans Administration Hospital, Oklahoma City, Oklahoma.Requests for reprints should be addressed to Edward M. Schneider, M.D., Miners Memorial Hospital, McDowell, Kentucky. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byClinical Pharmacology of Antihypertensive Drugs in ChildrenMechanisms of action of reserpine on gastric secretion of acidSecretion in the Heidenhain pouch of the rat stimulated by reserpineOn the Mechanism for the Stimulating Action of Reserpine on Acid Secretion in Gastric Fistula CatsGastric Acid Secretion in Gastric Fistula Cats during Reserpine Treatment 1Ulcerogenic drugs and technicsBiochemische, funktionelle und morphologische Organveränderungen durch Beeinflussung des 5-Hydroxytryptamin-StoffwechselsUlcerogenic drugsIatrogenic Diseases of the Gastrointestinal TractEffect of inhibited ACTH secretion on reserpine-induced hyperchlorhydriaDas PlaceboproblemThe TranquilizersComparative effects of atropine and Pro-Banthine on the stimulated human stomach 1 October 1957Volume 47, Issue 4Page: 640-650KeywordsAlkaloidsDuodenal ulcersExcretionGastroenterology and hepatologyHospital medicineHydrochloric acidPeptic ulcersReserpineStomach Issue Published: 1 October 1957 PDF downloadLoading ...