tbuckley/cabot-search huggingface dataset:
A decline in myometrial nitric oxide synthase expression is associated with labor and delivery.
Authors: R K Bansal, P C Goldsmith, Y He, C J Zaloudek, J L Ecker, R K Riemer
Journal: Journal of Clinical Investigation (1997)

The mechanisms that maintain relative uterine quiescence during pregnancy remain largely unknown. A possible role for nitric oxide has recently emerged, however, the expression of nitric oxide synthase within human myometrium at midgestation, a time when the uterus is normally quiescent, has not been investigated. The purpose of this study was to identify cell types in human myometrium that contain inducible nitric oxide synthase (iNOS), and to examine changes in its expression during pregnancy and labor. We found that iNOS is expressed in smooth muscle cells of pregnant myometrium. Expression of iNOS was highest in myometrium of preterm not-in-labor patients. At term, iNOS expression fell by 75%, and was barely detectable in preterm in-labor or term in-labor specimens. There was no staining in the myocytes of nonpregnant myometrium. Western blotting also revealed a similar pattern of changes in iNOS expression. In summary, iNOS expression in the myocytes of human myometrium is increased greatly during pregnancy, and declines towards term or with labor. Significantly, preterm inlabor patients also had a large decline in iNOS expression. These data suggest that changes in myometrial iNOS expression may participate in the regulation of uterine activity during human pregnancy.
Case 49-1991
Authors: R.T. Osteen, A.E. Rosenberg
Journal: New England Journal of Medicine (1991)

Presentation of CaseA 46-year-old man was admitted to the hospital because of leg swelling and a mass in the popliteal fossa.The patient was well until eight months earlier, when he fell while skiing and forced his right knee into a position of full flexion; he immediately felt a snap and experienced pain. He was able to ski down the mountain, but he remained inactive for the next several days, with improvement in the pain. During the next two months he believed that he had recovered completely.Five and a half months before admission, after a transatlantic flight, spontaneous . . .
Effect of angiotensin II on noradrenaline release in the human forearm
Authors: S. R Goldsmith, T. S Rector, A. J Bank, M. Garr, S. H Kubo
Journal: Cardiovascular Research (1994)

The aim was to test the hypothesis that in normal humans angiotensin II would stimulate local release of noradrenaline under basal conditions or during a sympathetic stimulus provided by lower body negative pressure (LBNP).Nine healthy volunteers received intra-arterial infusions of angiotensin II, 5 ng.min-1, into the non-dominant forearm. Forearm blood flow (strain gauge plethysmography) and regional noradrenaline spillover (using the tracer methodology of Esler) were measured during angiotensin II alone, LBNP alone, and LBNP plus angiotensin II.Angiotensin II and LBNP decreased forearm blood flow comparably: from 3.1(SD 1.5) to 2.4 (0.9) ml.100 g-1.min-1 during angiotensin II, p < 0.05; and from 3.3(1.5) to 2.5(1.0) ml.100 g-1.min-1 during LBNP, p < 0.05 (p = NS, A-II v LBNP). Angiotensin II had no effect on forearm venous noradrenaline or regional noradrenaline spillover. LBNP increased venous noradrenaline outflow from the forearm, from 1.6(0.40) to 2.1(0.6) nmol.min-1 (p < 0.05), while regional noradrenaline spillover tended to increase, rising from 1.5(0.8) to 2.0(1.0) nmol.100 ml-1.min-1. Angiotensin II did not enhance forearm blood flow or noradrenaline responses to LBNP.In the human forearm, mildly vasoconstrictor infusions of angiotensin II do not increase local release of noradrenaline, either alone or during mild LBNP. At least under these conditions, angiotensin II would not appear to be a potent influence on local sympathetic activity.
Observations on the Radionuclide Assessment of Peritoneovenous Shunt Patency
Authors: L ROSENTHALL, A ARZOUMANIAN, L G HAMPSON, H SHENNIB
Journal: Clinical Nuclear Medicine (1984)

ROSENTHALL, L M.D.; ARZOUMANIAN, A M.D.; HAMPSON, L G M.D.; SHENNIB, H M.D. Author Information
701-4 Factors Associated with Late Angiographic Outcome After Intravascular Ultrasound Guided Palmaz-Schatz Coronary Stent Implantation: A Multivariate Analysis
Authors: Patrick Hall, Shigeru Nakamura, Luigi Maiello, Simonetta Blenglno, Giovanni Martini, Leo Finci, Antonio Colombo
Journal: Journal of the American College of Cardiology (1995)
Expression from Second-Generation Feline Immunodeficiency Virus Vectors Is Impaired in Human Hematopoietic Cells
Authors: M PRICE, S CASE, D CARBONARO, X YU, D PETERSEN, K SABO, M CURRAN, B ENGEL, H MARGARIAN, J ABKOWITZ
Journal: Molecular Therapy (2002)

Vectors based on the feline immunodeficiency virus (FIV) have been developed as an alternative to those based on another lentivirus, human immunodeficiency virus-1 (HIV-1), because of theoretical safety advantages. We compared the efficiency of gene transfer and expression in human and feline hematopoietic progenitors using second-generation HIV-1 and FIV-based vectors. Vector pairs were tested using either human cytomegalovirus or murine phospho-glycerate kinase (PGK) internal promoters and were pseudotyped with the vesicular stomatitis virus G protein (VSV-G). Vector proviral copy numbers were similar in human and feline hematopoietic primary cells and cell lines transduced by HIV-1 or FIV vectors, demonstrating that both vectors are able to transfer genes efficiently to these cell types. HIV-1 vectors were well expressed in human primary hematopoietic cells and cell lines. However, transgene expression from FIV vectors was almost undetectable in human hematopoietic cells. In contrast, the FIV vector was expressed well in primary hematopoietic feline cells and human non-hematopoietic cells, demonstrating that low transgene expression from the FIV vector is a phenomenon specific to human hematopoietic cells. Northern blot analysis demonstrated decreased vector transcript levels in human CEM cells transduced with FIV relative to cells transduced with HIV-1, despite high vector copy numbers. No evidence of vector transcript instability was seen in studies of transduced CEM cells treated with actinomycin D. We conclude that FIV vectors can transfer genes into human hematopoietic cells as effectively as HIV-1 vectors, but that unknown elements in the current FIV backbone inhibit expression from FIV vectors in human hematopoietic cells.
Resistance to Urinary Tract Infection
Authors: Catharina Svanborg
Journal: New England Journal of Medicine (1993)

The healthy urinary tract is usually able to resist bacterial infection. However, urinary tract infections may occur in all age groups. The frequency is greater in women than in men, who are predominantly affected as children and in old age. A certain proportion of those with a first urinary tract infection will have recurrent infections. The mechanisms of host resistance, or rather the defects that might explain the increased susceptibility of certain persons to urinary tract infection, have been sought by analysis of the infection-prone groups. Conditions that impair urinary flow are known to predispose patients to infection. These include . . .
Adjunctive interferon-alpha-2c in stage IIIB/IV small-cell lung cancer: a phase III trial
Authors: C Prior, S Oroszy, W Oberaigner, E Schenk, F Kummer, K Aigner, H Hausmaninger, C Peschel, H Huber
Journal: European Respiratory Journal (1997)

Preliminary studies have shown bioactivity of interferons (IFNs) in the treatment of small-cell lung cancer (SCLC). The aim of the present study was to determine whether, in patients with advanced SCLC, a combination of recombinant IFN-alpha-2c and standard induction chemotherapy would improve response rates and survival at acceptable toxicity. Of the 85 patients recruited by 11 centres in Austria, 77 were evaluable for response after induction therapy; of these, 43 were randomized to receive the combined treatment (three cycles each of cyclophosphamide/vincristine/doxorubicin and cisplatin/etoposide plus subcutaneous IFN-alpha-2c), and 34 received chemotherapy alone. After the induction phase, patients in the IFN arm had higher rates of complete (30 vs 15%) and partial remission (42 vs 29%) than those who received chemotherapy alone. Accordingly, there was a lower rate of progressive disease in the interferon arm (21 vs 44%; p &lt; 0.05). Whilst there were no significant differences in time to progression (7.6 vs 5.4 months) patients in the IFN arm survived longer than those in the chemotherapy arm (p &lt; 0.02). Six of the patients treated with IFN (14%) survived for more than 2 yrs, whereas none in the chemotherapy arm did. We conclude that the addition of interferon-alpha-2c to induction chemotherapy may improve response rates and survival in advanced small-cell lung cancer.
Closer to an Effective Ebola Vaccine
Authors: M.J. Friedrich
Journal: JAMA (2015)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Myocyte mitotic division in the aging mammalian rat heart.
Authors: P Anversa, D Fitzpatrick, S Argani, J M Capasso
Journal: Circulation Research (1991)

To determine whether myocyte mitotic division occurs in the adult mammalian heart and whether this cellular process is affected by aging, we measured the percentage of myocyte nuclei showing metaphase chromosomes in myocytes isolated from the left and right ventricles of rats at 8-12, 19-24, and 28-32 months after birth. Metaphase chromosomes were found at all ages in both ventricles. However, from 8-12 to 28-32 months, the fraction of nuclei exhibiting metaphase chromosomes increased 6.3-fold and 2.3-fold in the left and right ventricles, respectively. Thus, myocyte cellular hyperplasia is present in the adult and aging myocardium as a compensatory mechanism to regenerate tissue mass and recover function, which are lost with the progression of life and senescence.
Fever and Rash in a 7-Month-Old Infant
Authors: Sarah J. Adams, Mina Y. Kingsbery, Sameera Husain, Maria C. Garzon
Journal: JAMA Pediatrics (2013)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Pediatrics HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Pediatrics journal
Relationship of Stroke to Other Cardiovascular Disease
Authors: GARY D. FRIEDMAN, DONALD B. LOVELAND, S. PAUL EHRLICH
Journal: Circulation (1968)

The frequencies of prior cardiovascular abnormalities were compared in 117 stroke patients and 234 control subjects. All were residents of a retirement community who had been examined initially and followed in the local medical clinic before the strokes occurred. Cases and controls were matched for age, sex, length of residence, and blood pressure. Prior coronary, rheumatic, and hypertensive heart disease were all more frequent in cases than in controls, as were cardiac enlargement, congestive heart failure, and digitalis therapy. There was a stronger association of stroke with atrial fibrillation than with other cardiac abnormalities, suggesting that atrial fibrillation in the elderly is an important precursor of stroke and should not be regarded lightly. Aortic calcification and intermittent claudication were also more frequent among the stroke cases than the controls. Since the blood pressures of cases and controls were matched, the association of both cardiac disease and noncerebral atherosclerosis with stroke is independent of blood pressure and is not attributable to the fact that hypertension predisposes to all of these conditions.
Respiratory Dysfunction in Systemic Lupus Erythematosus: An Unrecognized Abnormality.
Authors: Harold A. Lyons
Journal: Annals of Internal Medicine (1964)

s1 April 1964Respiratory Dysfunction in Systemic Lupus Erythematosus: An Unrecognized Abnormality.Harold A. Lyons, M.D., F.A.C.P., Chin-Tang Huang, M.D. (Associate), Gordon R. Hennigar, M.D.Harold A. Lyons, M.D., F.A.C.P.Search for more papers by this author, Chin-Tang Huang, M.D. (Associate)Search for more papers by this author, Gordon R. Hennigar, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-60-4-740_2 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptAlthough studies of organ involvement of systemic lupus erythematosus have been reported and are well known, these studies have been directed to kidney, joints, liver, and heart; little attention has been called to the pulmonary system. The radiologic abnormalities noted on chest films have received adequate description, but respiratory function has not been investigated.Twenty-two unselected patients with systemic lupus erythematosus, whose diagnosis was established, were subjected to investigation of their respiratory function. The findings were related to the duration of the disease, the presence of respiratory symptoms or radiological abnormalities, and the administration of steroid therapy.Determinations showed reduced... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: Harold A. Lyons, M.D., F.A.C.P.; Chin-Tang Huang, M.D. (Associate); Gordon R. Hennigar, M.D.Affiliations: Brooklyn, New York PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 April 1964Volume 60, Issue 4Page: 740-741KeywordsHeartKidneysLiverLongitudinal studiesLupus erythematosusPulmonary diseasesSteroid therapyThorax ePublished: 1 December 2008 Issue Published: 1 April 1964 PDF downloadLoading ...
LyralR is an important sensitizer in patients sensitive to fragrances
Authors: P.J. Frosch, J.D. Johansen, T. Menne, S.C. Rastogi, M. Bruze, K.E. Andersen, J.P. Lepoittevin, E. Gimenez Arnau, C. Pirker, A. Goossens, I.R. White
Journal: British Journal of Dermatology (1999)

Journal Article Lyral® is an important sensitizer in patients sensitive to fragrances Get access P.J. Frosch, P.J. Frosch Departments of Dermatology, Städtische Kliniken Dortmund and University of Witten/Herdecke, Beurhausstraße 40, 44123 Dortmund, Germany Prof. P.J.Frosch. E‐mail: stkd.hautklinik@dokom.net Search for other works by this author on: Oxford Academic Google Scholar J.D. Johansen, J.D. Johansen Gentofte Hospital, University of Copenhagen, Denmark Search for other works by this author on: Oxford Academic Google Scholar T. Menné, T. Menné Gentofte Hospital, University of Copenhagen, Denmark Search for other works by this author on: Oxford Academic Google Scholar S.C. Rastogi, S.C. Rastogi Department of Environmental Chemistry, National Environmental Research Institute, Roskilde, Denmark Search for other works by this author on: Oxford Academic Google Scholar M. Bruze, M. Bruze Department of Occupational and Environmental Dermatology, University Hospital, Malmö, Sweden Search for other works by this author on: Oxford Academic Google Scholar K.E. Andersen, K.E. Andersen Department of Dermatology, Odense University Hospital, Denmark Search for other works by this author on: Oxford Academic Google Scholar J.P. Lepoittevin, J.P. Lepoittevin Laboratoire de Dermatochimie, Université Louis Pasteur, Strasbourg, France Search for other works by this author on: Oxford Academic Google Scholar E. Giménez Arnau, E. Giménez Arnau Laboratoire de Dermatochimie, Université Louis Pasteur, Strasbourg, France Search for other works by this author on: Oxford Academic Google Scholar C. Pirker, C. Pirker Departments of Dermatology, Städtische Kliniken Dortmund and University of Witten/Herdecke, Beurhausstraße 40, 44123 Dortmund, Germany Search for other works by this author on: Oxford Academic Google Scholar A. Goossens, A. Goossens University of Leuven, Leuven, Belgium Search for other works by this author on: Oxford Academic Google Scholar ... Show more I.R. White I.R. White St John's Institute of Dermatology, St Thomas' Hospital, London SE1 7EH, U.K. Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 141, Issue 6, 1 December 1999, Pages 1076–1083, https://doi.org/10.1046/j.1365-2133.1999.03208.x Published: 01 December 1999
Lower your career sights, deputy chief medical officer advises future students
Authors: Lynn Eaton
Journal: BMJ (2007)

Medical students in the United Kingdom will need to scale down their career expectations in future, the deputy chief medical officer has warned, in the light of this year's problems in allocating junior doctors' training.

Speaking after an off the record press briefing on Monday, Martin Marshall told the BMJ that this year's job allocation process—including the flawed Medical Application Training Service (MTAS)—would have an impact on people's expectations when they consider a career in medicine in future because it has highlighted the tough competition for certain specialties.

“This has brought these issues to the fore,” he said. “I think it will change some expectations. But if that means we'll have more graduates applying for …
1113-155 Direct quantification of left ventricular volume by real-time three-dimensional echocardiography: Validation by cardiac magnetic resonance imaging
Authors: Enrico G Caiani, Lissa Sugeng, Cristiana Corsi, Peter MacEneaney, Lynn Weinert, Rick Koch, Roberto Battani, Keith A Collins, Victor Mor-Avi, Roberto M Lang
Journal: Journal of the American College of Cardiology (2004)
A Textbook of Epilepsy
Authors: John S. Garvin
Journal: JAMA (1977)

The editors of this book have done an excellent job. They present in one readable volume the most important modern information on epilepsy in a multidisciplinary approach. All of the contributors are British except for two from the United States. The entire volume is devoted to the patient with epilepsy and the problems, including medical, psychological, social, educational, and rehabilitative, that arise from the unpredictable nature of his attacks. It is emphasized that there are many questions regarding epilepsy about which we are still ignorant. After an introduction the first chapter is by a family physician who describes well the problems that occur for both the patient and the family when seizures occur. Another chapter describes in detail the clinical description of seizures, as well as various etiologies and prognoses, and gives a classification used throughout the book, but also has an appendix with the international classification. One entire chapter,
Improving Ambulatory Patient Safety
Authors: Matthew K. Wynia, David C. Classen
Journal: JAMA (2011)

THE 1999 INSTITUTE OF MEDICINE REPORT TO ERR IS Human: Building a Safer Health System launched the modern patient safety movement by estimating a large number of yearly error-related deaths among hospitalized patients in the United States. But 12 years later, there are no reliable data on how many patients in the United States are injured or die each year because of errors in ambulatory settings. The number may be substantial; 52% of paid medical malpractice claims in 2009 were for events in the outpatient setting, and two-thirds of these claims involved major injury or death. More than 10 years ago, a group of experts convened by the Agency for Healthcare Research and Quality (AHRQ) reported that “medical error and injury are substantial in ambulatory care, [but] there has been little systematic research specifically aimed at patient safety questions in ambulatory care.” To jump-start a new research agenda, the conferees made 11 specific recommendations. Virtually none have been implemented.
The Management of Cerebrovascular Disease
Authors: Fletcher McDowell
Journal: JAMA (1966)

The author, Dr. John Marshall, points out the enormous recent increase in the amount of published information on cerebrovascular disease. He is able, in this small volume, to summarize admirably the important advances in the pathophysiology and management of stroke.  He utilizes the current classification of cerebrovascular accidents, which includes the completed stroke, the evolving stroke, and the transient ischemic attack. The clinical section deals, in detail, with these three varieties and with the physical findings which may be used to distinguish among them. Particular attention is paid to the transient ischemic attack, for this provides warning of cerebrovascular disease before permanent neurological damage has occurred.  The present concepts of the pathophysiology of stroke are well discussed in the section on pathology, written by Drs. T. Crawford and M. R. Crompton. They give an excellent review of the neurovascular pathology of the three major subtypes.  Dr. Marshall, emphasizing that cerebral