Large Doses of Prednisone and Prednisolone in the Treatment of Malignant Lymphoproliferative Disorders
Authors: R A KYLE, C E McPARLAND, W DAMESHEK
Journal: Annals of Internal Medicine (1962)

Article1 November 1962Large Doses of Prednisone and Prednisolone in the Treatment of Malignant Lymphoproliferative DisordersROBERT A. KYLE, M.D., CLIFTON E. MCPARLAND, M.D., WILLIAM DAMESHEK, M.D., F.A.C.P.ROBERT A. KYLE, M.D.Search for more papers by this author, CLIFTON E. MCPARLAND, M.D.Search for more papers by this author, WILLIAM DAMESHEK, M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-57-5-717 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTreatment of the generalized chronic malignant lymphoproliferative disorders*is not standardized at all. In asymptomatic chronic lymphocytic leukemia, the best treatment is often no treatment. In the "aggressive" cases of chronic lymphocytic leukemia (1) and in generalized or disseminated lymphosarcomatosis, one of several therapeutic programs may be preferred. These include treatment with roentgen rays, nitrogen mustard, or one of the other alkylating agents [triethylene melamine (TEM), chlorambucil (Leukeran), or cyclophosphamide (Cytoxan)]; and corticosteroids. Each form of therapy has its adherents, and each may be said to have a special value in some phases of the patient's illness. In the last...References1. DAMESHEKGUNZ WF: Leukemia, Grune & Stratton, Inc., New York, 1958, p. 179. Google Scholar2. DAMESHEK W: A method for the simultaneous enumeration of blood platelets and reticulocytes: with consideration of the normal blood platelet count in men and in women. Arch. Intern. Med. 50: 579, 1932. CrossrefGoogle Scholar3. MCFARLANDDAMESHEK WW: Biopsy of bone marrow with the Vim-Silverman needle. JAMA 166: 1464, 1958. CrossrefMedlineGoogle Scholar4. WELLSKENDALL BBEC: A qualitative difference in the effect of compounds separated from the adrenal cortex on distribution of electrolytes and on atrophy of the adrenal and thymus glands of rats. Proc. Mayo Clin. 15: 133, 1940. Google Scholar5. DOUGHERTYWHITE TFA: Effect of pituitary adrenotropic hormone on lymphoid tissue. Proc. Soc. Exp. Biol. Med. 53: 132, 1943. CrossrefGoogle Scholar6. DOUGHERTYWHITE TFA: Influence of adrenal cortical secretion on blood elements. Science 98: 367, 1943. CrossrefMedlineGoogle Scholar7. DOUGHERTYWHITE TFA: Influence of hormones on lymphoid tissue structure and function: the role of the pituitary adrenotrophic hormone in the regulation of the lymphocytes and other cellular elements of the blood. Endocrinology 35: 1, 1944. CrossrefGoogle Scholar8. HEILMANKENDALL FREC: The influence of 11-dehydro-17-hydroxycorticosterone (compound E) on the growth of a malignant tumor in the mouse. Endocrinology 34: 416, 1944. CrossrefGoogle Scholar9. MURPHYSTURM JBE: The effect of adrenal cortical and pituitary adrenotropic hormones on transplanted leukemia in rats. Science 99: 303, 1944. CrossrefMedlineGoogle Scholar10. LAWSPEIRS LWR: Response of spontaneous lymphoid leukemias in mice to injection of adrenal cortical extracts. Proc. Soc. Exp. Biol. Med. 66: 226, 1947. CrossrefMedlineGoogle Scholar11. PEARSONELIELRAWSONDOBRINERRHOADS OHLPRWKCP: ACTH- and cortisone-induced regression of lymphoid tumors in man: a preliminary report. Cancer 2: 943, 1949. CrossrefMedlineGoogle Scholar12. PEARSONELIEL OHLP: Use of pituitary adrenocorticotropic hormone (ACTH) and cortisone in lymphomas and leukemias. JAMA 144: 1349, 1950. CrossrefMedlineGoogle Scholar13. ROSENTHALSAUNDERSSCHWARTZZANNOSSANTIAGODAMESHEK MCRHLILEPW: The use of adrenocorticotropic hormone and cortisone in the treatment of leukemia and leukosarcoma. Blood 6: 804, 1951. CrossrefMedlineGoogle Scholar14. NABARROSTEWARTWALKER JDJSG: Clinical and metabolic effects of prednisone. Lancet 2: 993, 1955. CrossrefGoogle Scholar15. SPURRHAYES CLDM: Treatment of various hematologic disorders: use of triamcinolone. Amer. Practit. 10: 2113, 1959. Google Scholar16. HILLMARSHALLFALCO JMGJDJ: Massive prednisone and prednisolone therapy in leukemia and lymphomas in the adult. J. Amer. Geriat. Soc. 4: 627, 1956. CrossrefMedlineGoogle Scholar17. RANNEYGELLHORN HMA: The effect of massive prednisone and prednisolone therapy on acute leukemia and malignant lymphomas. Amer. J. Med. 22: 405, 1957. CrossrefMedlineGoogle Scholar18. DUBOIS-FERRIÈRE H: Possibilitiés et limites du traitement des lymphomes malins par la prednisone à doses massives. Praxis 47: 85, 1958. MedlineGoogle Scholar19. SUSSMAN LN: Large-dose prednisone therapy of hematologic diseases. New York J. Med. 58: 2950, 1958. MedlineGoogle Scholar20. YUNISHARRINGTON AAWJ: Clinical use of methyl-prednisolone in certain hematologic disorders. Metabolism 7: 543, 1958. MedlineGoogle Scholar21. RENNER D: Die Behandlung eines Falles von Lymphosarkomatose mit hohen Dosen von Nebennierenrindensteroiden. Wien. Med. Wschr. 108: 261, 1958. Google Scholar22. GROSSLUDWIG RH: Hochdosierte Prednisonund Prednisolonbehandlung bei Blutkrankheiten. Klin. Wschr. 34: 1117, 1956. CrossrefMedlineGoogle Scholar23. DAMESHEK W: The use of corticosteroids in hematological therapy. Ann. N. Y. Acad. Sci. 82: 924, 1959. CrossrefMedlineGoogle Scholar24. FREYMANNVANDERBURRELLMARLER JGJBSBEA: Corticosteroid therapy of chronic lymphocytic leukaemia: a study of erythrocyte survival and leukocyte dynamics. Acta Un. Int. Cancr. 16: 849, 1960. MedlineGoogle Scholar25. FREYMANNVANDERMARLERMEYER JGJBEDG: Prolonged corticosteroid therapy of chronic lymphocytic leukaemia and the closely allied malignant lymphomas. Brit. J. Haemat. 6: 303, 1960. CrossrefMedlineGoogle Scholar26. SHAWBOGGSSILBERMANFREI RKDRHRE: A study of prednisone therapy in chronic lymphocytic leukemia. Blood 17: 182, 1961. CrossrefGoogle Scholar27. GALTONWILTSHAWSZURDACIE DAELJV: The use of chlorambucil and steroids in the treatment of chronic lymphocytic leukaemia. Brit. J. Haemat. 7: 73, 1961. CrossrefMedlineGoogle Scholar28. RUNDLESCOONRADARENDS RWEVT: Serum proteins in leukemia. Amer. J. Med. 16: 842, 1954. CrossrefMedlineGoogle Scholar29. KAPLANNAGAREDA HSCS: On the possibility of cure of malignant lymphoid tumors. I. Treatment of autochthonous lymphoid tumors in C57BL mice with massive doses of lymphocytolytic agents. Blood 18: 166, 1961. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Boston, MassachusettsFrom the Blood Research Laboratory, Pratt Diagnostic Clinic, New England Center Hospital, and the Department of Medicine, Tufts University School of Medicine, Boston, Massachusetts.Dr. Kyle carried out this work while under the tenure of United States Public Health Service Fellowship HF-11-525.Requests for reprints should be addressed to Mayo Clinic, Rochester, Minnesota.*Malignant lymphoproliferative disorders include chronic lymphocytic leukemia and lymphosarcomas, but exclude Hodgkin's disease and reticulum cell sarcoma. 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KRANT, M.D.Weekly High-Dosage Glucocorticosteroid Treatment of Lymphocytic Leukemias and LymphomasNewer Anticancer Agents“Spontaneous” remission in chronic lymphatic leukemia? 1 November 1962Volume 57, Issue 5Page: 717-731KeywordsChronic lymphocytic leukemiaDiagnostic medicineHospital medicineLymphoproliferative disorderOsteoporosisPneumoniaResearch laboratoriesSarcomaSepsisSteroid therapy ePublished: 1 December 2008 Issue Published: 1 November 1962 PDF downloadLoading ...