tbuckley/cabot-search huggingface dataset:
Clinical efficacy of cardiac resynchronization therapy using left ventricular pacing in heart failure patients stratified by severity of ventricular conduction delay
Authors: Angelo Auricchio, Christoph Stellbrink, Christian Butter, Stefan Sack, Jürgen Vogt, Anand Ramdat Misier, Dirk Böcker, Michael Block, Johannes H Kirkels, Andrew Kramer, Etienne Huvelle
Journal: Journal of the American College of Cardiology (2003)
Meaningful Use of Health Information Technology in U.S. Hospitals
Authors: Catherine M. DesRoches, Sara J. Rosenbaum
Journal: New England Journal of Medicine (2010)

Meaningful Use of Health Information Technology in U.S. Hospitals Provisions of the American Recovery and Reinvestment Act included payments for the 0;meaningful use1; of certified electronic health record technology. In this survey of health information technology in acute care hospitals, a minority of hospitals had the necessary systems to achieve meaningful use.
PWE-124 Colesevelam use and efficacy for bile acid malabsorption
Authors: O Orekoya, J McLaughlin, E Leitao, W Johns, P Paine
Journal: Gut (2012)

<h3>Introduction</h3> Bile acid malabsorption (BAM) is a common cause of chronic diarrhoea that can be diagnosed by the SeHCAT test and treated with bile acid sequestrants (BAS). Colestyramine, the most commonly used BAS, is often poorly tolerated due to side effects including nausea, vomiting, flatulence and abdominal pain. Colesevelam, has recently been advocated, as a second line BAS therapy in patients who poorly tolerate colestyramine.<sup>1</sup> The purpose of this retrospective study was to determine the current use and efficacy of colesevelam in bile acid malabsorption. <h3>Methods</h3> Case records were reviewed over a 6-year period for patients found to have a positive SeHCAT test (defined as retention ≤8%). The age and sex, indication for SeHCAT test, use of BAS and clinical response were noted. <h3>Results</h3> SeHCAT tests were performed in 264 patients, of which a positive SeHCAT was found in 104 (39%). Data on use and response to BAS were found in 73. The majority (n=68) were given colestyramine as first line treatment with only five receiving colesevelam first line. Symptom improvement with colestyramine occurred in 41/68 (60%). 27/68 (40%) failed colestyramine therapy of which 2/3 were due to poor tolerance. 12 of these were then offered second line therapy with colesevelam. 42% of the 12 patients (n=5) who were given colesevelam after failing to respond to or tolerate colestyramine had a positive response to colesevelam second line. None of the patients reported poor tolerance to colesvelam. Overall BAS response was slightly higher among male patients (76% success in males vs 60% success in females) but there were no differences between different age groups. <h3>Conclusion</h3> This retrospective study indicates a good response rate and good tolerance to colesevelam in colestyramine non-responders; however its use as second line therapy was low for reasons that are unclear. Further study is needed to establish whether colesevelam might have better efficacy than colestyramine as first line therapy and to raise awareness of its availability. <h3>Competing interests</h3> None declared. <h3>Reference</h3> 1. <b>Wedlake L</b>, A9Hern R, Russell D, <i>et al</i>. Systematic review: the prevalence of idiopathic bile acid malabsorption as diagnosed by SeHCAT scanning in patients with diarrhoea-predominant irritable bowel syndrome. <i>Aliment Pharmacol Ther</i> 2009;<b>30</b>:707–17.
Regulation of Blood Flow to the Aortic Media in Dogs
Authors: Donald D. Heistad, Melvin L. Marcus, Edward G. Law, Mark L. Armstrong, James C. Ehrhardt, Francois M. Abboud
Journal: Journal of Clinical Investigation (1978)

Morphologic observations suggest that the inner layers of the thoracic aorta in man and dog are avascular and the outer layers have vasa vasorum. It appears that vasa vasorum are essential in the thoracic aorta because their interruption produces medial necrosis. These experiments provide the first measurements of blood flow through aortic vasa vasorum and examine physiologic regulation of that flow.
Carbamazepine and false positive dexamethasone suppression tests for Cushing's syndrome
Authors: Ronald C W Ma, Wing Bun Chan, Wing Yee So, Peter C Y Tong, Juliana C N Chan, Chun Chung Chow
Journal: BMJ (2005)

tery for low resource settings, including further research on developing simple, acceptable, and low cost approaches for sterilisation and reuse of cautery tips.The experts also discussed programmatic research, including prospective evaluations of different techniques, studies to determine the feasibility of implementing and training providers on various techniques, and research to identify practical differences between the techniques and perhaps to make recommendations for providers depending on the number of vasectomies done in a particular clinical setting.Future research should clarify the appropriate use of cautery and fascial interposition in low resource settings.We thank John M Pile of EngenderHealth, Tim Black of Marie Stopes International, and Michel Labrecque of Laval University for careful review of this document.We also thank the clinicians who participated in the vasectomy studies we cited and the participants in both expert consultations on vasectomy, whose leadership and vision were invaluable in developing the points of consensus shared here.
Scientists Examine Benefits, Risks of Treating Preschoolers With ADHD Drugs
Authors: Bridget M. Kuehn
Journal: JAMA (2007)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Primary Thymic Mucosa-Associated Lymphoid Tissue Lymphoma: Diagnostic Tips
Authors: Kimihiro Shimizu, Junji Yoshida, Seiichi Kakegawa, Jun Astumi, Kyoichi Kaira, Kiyohiro Oshima, Tomomi Miyanaga, Mitsuhiro Kamiyoshihara, Kanji Nagai, Izumi Takeyoshi
Journal: Journal of Thoracic Oncology (2010)
Central Precocious Puberty Caused by Mutations in the Imprinted Gene <i>MKRN3</i>
Authors: Ana Paula Abreu, Andrew Dauber, Delanie B. Macedo, Sekoni D. Noel, Vinicius N. Brito, John C. Gill, Priscilla Cukier, Iain R. Thompson, Victor M. Navarro, Priscila C. Gagliardi, Tânia Rodrigues, Cristiane Kochi, Carlos Alberto Longui, Dominique Beckers, Francis de Zegher, Luciana R. Montenegro, Berenice B. Mendonca, Rona S. Carroll, Joel N. Hirschhorn, Ana Claudia Latronico, Ursula B. Kaiser
Journal: New England Journal of Medicine (2013)

The onset of puberty is first detected as an increase in pulsatile secretion of gonadotropin-releasing hormone (GnRH). Early activation of the hypothalamic–pituitary–gonadal axis results in central precocious puberty. The timing of pubertal development is driven in part by genetic factors, but only a few, rare molecular defects associated with central precocious puberty have been identified.
Serial measurement of the N‐terminal pro‐brain natriuretic peptide (NT‐proBNP) predicts poor outcome in a patient with congenitally corrected transposition of the great arteries (ccTGA)
Authors: Tanja M. Raedle‐Hurst, Meryem Hosse, Hashim Abdul‐Khaliq
Journal: European Journal of Heart Failure (2010)
Significance of Thyroid Transcription Factor 1 Expression in Patients with Nonsquamous Nsclc Treated with Pemetrexed Based Chemotherapy
Authors: X. Mielgo, A. Velastegui Ordoñez, R. Martínez Cabañes, A.C. Rosero, L. Ruiz-Giménez, J.C. Cámara, S. Hernando, A. Hurtado, C. Olier
Journal: Annals of Oncology (2015)
Delayed diagnosis: longer and improved GP training and more GPs are the answer
Authors: D. Pereira Gray, P. Evans, E. White, A. Harding, P. Langley
Journal: BMJ (2014)

Hawkes describes how NHS gatekeeping delays diagnosis.1 A serious problem exists in all health systems in quickly diagnosing serious rare diseases. UK NHS cancer outcomes are worse than in some continental countries. GP delay in diagnosis is a serious problem, but so is post-referral delay, relatively fewer x ray machines, and fewer specialist treatments available—both drugs and radiotherapy.

England has 28% fewer …
Chylous ascites following retroperitoneal lymphadenectomy in gynecologic malignancies: Incidence, risk factors and management
Authors: Ulas Solmaz, Volkan Turan, Emre Mat, Murat Levent Dereli, Atalay Ekin, Nuri Peker, Gokhan Tosun, Askin Dogan, Mehmet Gokcu, Muzaffer Sanci
Journal: International Journal of Surgery (2015)
Ephedrine is Not Phenylephrine
Authors: Timothy B. Gilbert
Journal: New England Journal of Medicine (1998)

To the Editor: In his review of Dermatology in Emergency Care (Feb. 12 issue),1 Dr. Greaves incorrectly uses the generic name ephedrine for a 2 percent phenylephrine spray used to treat a localized mucosal reaction. Phenylephrine hydrochloride is an α-adrenergic agonist that is useful for topical as well as intravenous vasoconstriction. It is commonly dispensed (in the United States, at least) as a 1 percent concentration. Ephedrine, a generic, indirect-acting sympathomimetic agent, is ubiquitous in perioperative care. It is dispensed in 5 percent ampules that are generally diluted before use. These drugs are therefore not equivalent.
Serotonergic mechanisms responsible for levodopa-induced dyskinesias in Parkinson’s disease patients
Authors: Marios Politis, Kit Wu, Clare Loane, David J. Brooks, Lorenzo Kiferle, Federico E. Turkheimer, Peter Bain, Sophie Molloy, Paola Piccini
Journal: Journal of Clinical Investigation (2014)

Levodopa-induced dyskinesias (LIDs) are the most common and disabling adverse motor effect of therapy in Parkinson's disease (PD) patients. In this study, we investigated serotonergic mechanisms in LIDs development in PD patients using 11C-DASB PET to evaluate serotonin terminal function and 11C-raclopride PET to evaluate dopamine release. PD patients with LIDs showed relative preservation of serotonergic terminals throughout their disease. Identical levodopa doses induced markedly higher striatal synaptic dopamine concentrations in PD patients with LIDs compared with PD patients with stable responses to levodopa. Oral administration of the serotonin receptor type 1A agonist buspirone prior to levodopa reduced levodopa-evoked striatal synaptic dopamine increases and attenuated LIDs. PD patients with LIDs that exhibited greater decreases in synaptic dopamine after buspirone pretreatment had higher levels of serotonergic terminal functional integrity. Buspirone-associated modulation of dopamine levels was greater in PD patients with mild LIDs compared with those with more severe LIDs. These findings indicate that striatal serotonergic terminals contribute to LIDs pathophysiology via aberrant processing of exogenous levodopa and release of dopamine as false neurotransmitter in the denervated striatum of PD patients with LIDs. Our results also support the development of selective serotonin receptor type 1A agonists for use as antidyskinetic agents in PD.
Significance of Fibrillatory Waves and the P Terminal Force in Idiopathic Atrial Fibrillation
Authors: ROBERT H. PETER
Journal: Annals of Internal Medicine (1968)

The amplitude of the fibrillatory waves and the magnitude of the P terminal force in lead V1 of the electrocardiogram were examined in 30 patients without evident organic heart disease who were diagnosed as having idiopathic atrial fibrillation. Twenty-six patients (86%) had both fine fibrillatory waves and a subsequently normal P terminal force. None of the patients in the series had fibrillatory or P wave abnormalities of the magnitude seen in the majority of patients with known heart disease of the types associated with left atrial hypertrophy. It is concluded that either a fine fibrillatory wave or a normal P terminal force mitigates against the presence of left atrial hypertrophy.
Tumor necrosis factor-β gene Nco I polymorphism decreases insulin resistance in Japanese men
Authors: Tetsuo Hayakawa, Yukihiro Nagai, Masayuki Taniguchi, Haruhisa Yamashita, Toshinari Takamura, Toshio Abe, Gakuji Nomura, Ken-ichi Kobayashi
Journal: Metabolism (2000)
Careers advice for doctors
Authors: D. Carnall, R. Smith
Journal: BMJ (1996)

Although unemployment among doctors is rare, many doctors express dissatisfaction with their work. This mismatch between expectation and reality may in part be due to doctors not receiving adequate advice on their careers. This week we launch a new section in the BMJ designed to respond to this lack. Career Focus, as the new section is known, will be published each week in the classified advertising supplements and will help keep doctors abreast of the many possible avenues that their working lives may follow.

The one thing we know for sure about the NHS of the future is that it will be different from now. Last month the British Association of Medical Managers (BAMM) gathered together a team of hospital doctors and managers to play …
High-throughput sequencing screen reveals novel, transforming RAS mutations in myeloid leukemia patients
Authors: Jeffrey W. Tyner, Heidi Erickson, Michael W. N. Deininger, Stephanie G. Willis, Christopher A. Eide, Ross L. Levine, Michael C. Heinrich, Norbert Gattermann, D. Gary Gilliland, Brian J. Druker, Marc M. Loriaux
Journal: Blood (2008)
Global life expectancy rises
Authors: J. Wise
Journal: BMJ (1998)

The World Health Organisation has painted an optimistic picture of life in the 21st century—in industrialised countries people are going to be healthier and live longer. But although improvements have been seen in developing countries, 21 million still face premature death this year.

The World Health Report 1998 says that worldwide, premature deaths (defined as occurring before the age …
Current Topics in Medical Mycology
Authors: Donald G. Ahearn
Journal: JAMA (1986)

This is the first volume of an annual series intended to summarize current topics in medical mycology. The volumes are to include reviews, summaries of current advancements, and future directions and mechanisms. The first volume contains 12 chapters. The subjects are mycoses in the acquired immunodeficiency syndrome, yeast cell walls, animal models for candidiasis, dermatophyte antigens and cell-mediated immunity in dermatophytosis, natural cell-mediated resistance against<i>Cryptococcus neoformans</i>, biotyping of medically important fungi, protein and mannan polysaccharide antigens, epidemiology of dermatophytes,<i>Paracoccidioides brasiliensis</i>cell-wall glucans' pathogenicity and dimorphism, zinc in<i>Candida</i>dimorphism, killer yeasts, and the action of antifungal azole derivatives. The volume contains a helpful subject index, and each chapter has an extensive list of references with complete citations. All chapters include some references up to 1983 through 1984. The volume is well edited and well illustrated with diagrams and high-quality light and electron photomicrographs. There is some redundancy. The
Private hospitals to boost public service capacity in Ireland
Authors: Muiris Houston
Journal: BMJ (2005)

Ireland is to get 1000 additional hospital beds for public health service patients by building private hospitals on public hospital sites. The move is designed to partially fill an acknowledged 3000 bed deficit in the public hospital system, and Mary Harney, the minister for health, said that private investors would receive tax incentives to build the new hospitals.

Ireland has a mixed public and private heath system, with 30% of the 4 million population entitled to free health …
Induction of Estradiol Metabolism by Dietary Indole-3-carbinol in Humans
Authors: J. J. Michnovicz, H. L. Bradlow
Journal: JNCI Journal of the National Cancer Institute (1990)

Journal Article Induction of Estradiol Metabolism by Dietary Indole-3-carbinol in Humans Get access Jon J. Michnovicz, Jon J. Michnovicz * The Rockefeller University, New York, NY,and The Institute for Human Research, New York, NY. *Correspondence to: Jon J. Michnovicz, M.D., Ph.D., The Institute for Hormone Research, 55 E. 34th St., New York, NY 10016. Search for other works by this author on: Oxford Academic PubMed Google Scholar H. Leon Bradlow H. Leon Bradlow The Rockefeller University, New York, NY,and The Institute for Human Research, New York, NY. Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 82, Issue 11, 6 June 1990, Pages 947–949, https://doi.org/10.1093/jnci/82.11.947 Published: 06 June 1990 Article history Received: 08 January 1990 Revision received: 06 March 1990 Accepted: 13 March 1990 Published: 06 June 1990
Sleep and Psychiatric Disorders in Children and Adolescents
Authors: Dennis Rosen
Journal: JAMA (2009)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Congress Passes Bill to Ban Discrimination Based on Individuals’ Genetic Makeup
Authors: Tracy Hampton
Journal: JAMA (2008)

IN A MOVE TO PROTECT INDIVIDUALS from health insurance or employment discrimination based on their genetic information, both the House and Senate have overwhelmingly passed the Genetic Information Nondiscrimination Act (GINA). The protections provided by the act are meant to encourage US individuals to obtain genetic testing as part of their medical care without fear of discrimination. The progress of GINA’s passage can be tracked at http://www.genome.gov /24519851. At press time, President Bush, who was among those who urged Congress to pass such legislation, was expected to sign the bill into law. “We want medical research to go forward without an individual fearing of personal discrimination,” Bush said during a roundtable discussion at the National Institutes of Health (NIH) last year.
Barium Intravasation Into Portal Venous System During Barium Enema Examination
Authors: Anthony F. Salvo
Journal: JAMA (1976)

BARIUM enema examination has had a very low complication rate, approximately two in 10,000 studies. During a 20-year period at the Columbia Presbyterian Hospital (New York), Seaman and Wells<sup>1</sup>found only 13 examples of perforation of the colon during barium enema examination. We have recently encountered a unique complication of the barium enema, one that has been reported only once before, to our knowledge, ie, intravasation of barium into the portal venous system. This occurred during a barium enema examination of a patient with ulcerative colitis. <h3>Report of a Case</h3> A 36-year-old woman had had upper gastrointestinal bleeding, thought to be from a duodenal ulcer, in 1970 and 1972; both episodes were controlled medically. The patient had a history of chronic alcoholism. Approximately one month before admission, she experienced weakness, anorexia, and nausea, and passed several black stools. She had also lost 4.5 kg (10 lb) during this month.
Diagnosing Streptococcal Pharyngitis in Patients Taking Antibiotics
Authors: Philip Brunell
Journal: JAMA (1997)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal