PRIMARY AND SECONDARY MYELOFIBROSIS (A CLINICAL AND PATHOLOGICAL STUDY OF THIRTEEN CASES OF FIBROSIS OF THE BONE MARROW)
Authors: Lowell A. Erf, Peter A. Herbut
Journal: Annals of Internal Medicine (1944)

Article1 November 1944PRIMARY AND SECONDARY MYELOFIBROSIS (A CLINICAL AND PATHOLOGICAL STUDY OF THIRTEEN CASES OF FIBROSIS OF THE BONE MARROW)LOWELL A. ERF, M.D., F.A.C.P., PETER A. HERBUT, M.D.LOWELL A. ERF, M.D., F.A.C.P.Search for more papers by this author, PETER A. HERBUT, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-21-5-863 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptMyelofibrosis means fibrosis of the bone marrow. The process may be either focal or generalized, primary or secondary, mild or severe, and may or may not be associated with various degrees of myelosclerosis (defined as an excessive proliferation of endosteal bone, known also as osteosclerosis) in any or all bones of the body. Among others, fibrosis of the bone marrow has been observed in the following conditions:A. Focal:I. Primary (idiopathic),1. Such a condition has not been described unless Albright's disease1 can be considered as such, or2. Monomelic medullary osteosclerosis2 (case 1, table 1).II. Secondary to...Bibliography1. ALBRIGHTBUTLERHAMPTONSMITH FAMAOP (a) : Syndrome characterized by osteitis fibrosa disseminata, areas of pigmentation and endocrine dysfunction with precocious puberty in females, New England Jr. Med., 1937, ccxvi, 727. (b) ALBRIGHT, F., SCOVILLE, B., and SULKOWITCH H. W.: Syndrome characterized by osteitis fibrosa disseminata, areas of pigmentation and a gonadal dysfunction, Endocrinology, 1938, xxii, 411. CrossrefGoogle Scholar2. HOROWITZ T: Monomelic medullary osteosclerosis, Radiology, 1941, xxxvi, 343. CrossrefGoogle Scholar3. TURNBULL HM: Studies in calcium and phosphorus metabolism in generalized diseases of bones, Proc. Roy. Soc. Med., 1935, xxviii, 1619. Google Scholar4. HERTZLER AE: Surgical pathology of the diseases of bones, 1931, J. B. Lippincott, Philadelphia. Google Scholar5. LAWFORD RL: The inflammatory and toxic diseases of bone, 1926, John Wright and Sons, London. Google Scholar6. FALCONERCOPE MACL: Fibrous dysplasia of bone with endocrine disorders and cutaneous pigmentation (Albright's disease), Quart. Jr. Med., 1942, xi, 112. Google Scholar7. CURTISFELLER LEAE: Hyperparathyroidism with calcinosis and secondary to renal disease, Ann. Int. Med., 1942, xvii, 1005. Google Scholar8. HUGGINSWIEGE CE: Effect on bone marrow of disruption of nutrient artery and vein, Ann. Surg., 1939, cx, 940. CrossrefGoogle Scholar9. KISTLER GH: Sequences of experimental infarction of the femur in rabbits, Arch. Surg., 1934, xxix, 589. CrossrefGoogle Scholar10. METTIERRUSK SRGY: Fibrosis of the bone marrow (myelofibrosis) associated with a leukemoid blood picture, Am. Jr. Path., 1937, xiii, 377. Google Scholar11. ROSENTHALERF NLA: Clinical observations on osteopetrosis and myelofibrosis, Arch. Int. Med., 1943, lxxi, 793. CrossrefGoogle Scholar12. HICKLING RA: Chronic non-leukemic myeloids, Quart. Jr. Med., 1937, vi, 253. Google Scholar13. PARKES-WEBER F: Generalized osteosclerosis, Jr. Path. and Bact., 1929, xxxii, 171. Google Scholar14. FAIRBANK HA: Increased and decreased density of bone with special reference to fibrosis of the marrow, Brit. Jr. Surg., 1939, xxvii, 1. CrossrefGoogle Scholar15. RUSKMILES GYWL: Osteosclerotic anemia secondary to epidermoid carcinoma, Am. Jr. Path., 1927, iii, 289. Google Scholar16. METTIER SR: Hematologic aspects of space consuming lesions of the bone marrow (myelophthisic anemia), Ann. Int. Med., 1940, xiv, 436. Google Scholar17. JARCHO S: Diffusely infiltrative carcinoma, Arch. Path., 1936, xxii, 674. Google Scholar18. THOMPSONILLYNE WPCA: Clinical and hematological picture resulting from bone marrow replacement, Med. Clin. North Am., 1940, xxiv, 841. CrossrefGoogle Scholar19. VAUGHNHARRISON JCV: Leuco-erythroblastic anemia and myelosclerosis, Jr. Path. and Bact., 1939, xlviii, 339. CrossrefGoogle Scholar20. HYNES M: Sternal puncture, Lancet, 1939, i, 1373. CrossrefGoogle Scholar21. VAUGHN JM: Leuco-erythroblastic anemia, Jr. Path. and Bact., 1936, xlii, 541. CrossrefGoogle Scholar22. DONHAUSERDE ROUVILLE JLWH: Multiple myeloma, with special reference to soft tissue metastases, Arch. Surg., 1941, xliii, 946. CrossrefGoogle Scholar23. HIRSCH EF: Generalized osteosclerosis with chronic polycythemia vera, Trans. Chicago Path. Soc., 1935, xiv, 204. Google Scholar24. PINKERTON H: Aleukemic leukemia and atypical leukemoid conditions, Arch. Path., 1929, vii, 567. Google Scholar25. ABRAMS HS: The osseous system in Hodgkin's disease, Ann. Surg., 1938, cviii, 296. CrossrefGoogle Scholar26. MENDELOFFROSENTHAL TJ: Leukoerythroblastic anemia with diffuse osteosclerosis, Ann. Int. Med., 1943, xix, 518. Google Scholar27. COOLEYWITWERLEE TBERP: Anemia in children, Am. Jr. Dis. Child., 1927, xxxiv, 347. CrossrefGoogle Scholar28. GALL EA: Benzene poisoning with bizarre extra-medullary hematopoiesis, Arch. Path., 1938, xxv, 315. Google Scholar29. LINSMANMCMURRAY JFCA: Fluoride osteosclerosis from drinking water, Radiology, 1943, xl, 474. CrossrefGoogle Scholar30. MARTLAND HS: The occurrence of malignancy in radioactive persons, Am. Jr. Cancer, 1931, xv, 2435. Google Scholar31. MULLIGAN RM: Effects of repeated small doses of roentgen rays on canine blood and bone marrow, Proc. Soc. Exper. Med. and Biol., 1941, xlviii, 607. CrossrefGoogle Scholar32. LEHNERDT F: Phosphorsklerose und Strontiumsklerose, Jahrb. f. Kinderh., 1910, lxxii, 394. Google Scholar33. GARDNERPFEIFFER WUCA: Influence of estrogens and androgens on the skeletal system, Physiol. Rev., 1943, xxiii, 139. CrossrefGoogle Scholar34. CASTRODALEBIERBAUMHELWIGMACBRYDE DOEBCM: Comparative studies of the effects of estradiol and stilbesterol upon the blood, liver and bone marrow, Endocrinology, 1941, xxix, 363. CrossrefGoogle Scholar35. MILLERORRPYBUS EWJWFC: The effect of estrone on the mouse skeleton, Jr. Path. and Bact., 1943, lv, 137. CrossrefGoogle Scholar36. BUNTING CH: Experimental anemias in the rabbit, Jr. Exper. Med., 1906, viii, 625. CrossrefGoogle Scholar37. FIRKETCAMPOS JES: Generalized megalocaryocytic reaction to saponin poisoning, Bull. Johns Hopkins Hosp., 1922, xxxiii, 271. Google Scholar38. NETTLESHIP A: Bone-marrow changes produced by specific antibodies, Am. Jr. Path., 1942, xviii, 689. Google Scholar39. SILBERBERGSILBERBERG MR: Comparison of effects of anterior pituitary hormone on skeletal tissues of young and mature guinea pigs, Am. Jr. Path., 1939, xv, 547. Google Scholar40. SILBERBERGSILBERBERG MR: Growth processes in cartilage and bone subsequent to gonadectomy and administration of anterior pituitary extract of cattle in immature male and female guinea pigs, Am. Jr. Path., 1939, xv, 55. Google Scholar41. SELYE H: On the stimulation of new bone-formation with parathyroid extract and irradiated ergosterol, Endocrinology, 1932, xvi, 545. Google Scholar42. MILLERTURNER FDL: The action of specific stimulators on the hematopoietic system, Am. Jr. Med. Sci., 1943, ccvi, 143. Google Scholar43. HEUCH G: Zwei Fälle von Leukämie mit eigenthümlichen Blut resp. Knockenmarksbefund, Virchow's Arch. f. path. Anat., 1879, lxxviii, 475. CrossrefGoogle Scholar44. DONHAUSER JL: The human spleen as a hematoplastic organ as exemplified in a case of splenomegaly with sclerosis of the bone marrow, Bull. Ayer Clin. Lab., 1908, v, 46. Google Scholar45. BALLINMORSE MPF: Myelophthisic splenomegaly, Jr. Am. Med. Assoc., 1927, lxxxix, 1671. CrossrefGoogle Scholar46. CHAPMAN EM: Osteosclerotic anemia, Am. Jr. Med. Sci., 1933, clxxxv, 171. CrossrefGoogle Scholar47. STEPHENSBREDECK DJJF: Aleukemic myelosis with osteosclerosis, Ann. Int. Med., 1933, vi, 1087. Google Scholar48. FRANK E: Aleukia haemorrhagica, Berl. klin. Wchnschr., 1915, lii, 961. Google Scholar49. VAUGHN J: The anaemias, 1934, Oxford University Press, London. Google Scholar50. MAGNER W: Textbook of hematology, 1936, Blakiston's Son and Co., Philadelphia, p. 166. Google Scholar51. TAYLORSMITH HERP: Marrow sclerosis associated with massive myeloid splenomegaly, Arch. Path., 1941, xxxi, 803. Google Scholar52. TUDHOPE GR: Splenomegaly with myeloid transformation, Jr. Path. and Bact., 1937, xliv, 99. CrossrefGoogle Scholar53. FALCONERRYRIE AWBJ: Report on a familial type of generalized osteosclerosis, Med. Press, 1937, cxcv, 12. Google Scholar54. JORDANSCOTT HEJK: A case of osteosclerosis with extensive extra-medullary hemopoiesis and a leukemic blood reaction, Arch. Path., 1941, xxxii, 895. Google Scholar55. MCMICHAELMCNEE JJW: Leuco-erythroblastosis, Edinburgh Med. Jr., 1936, xliii, 303. Google Scholar56. BISKINDBISKIND MSGR: Effect of vitamin B complex deficiency on inactivation of estrone in the liver, Endocrinology, 1942, xxxi, 109. CrossrefGoogle Scholar57. DOWNEYPALMERPOWELL HML: The origin of the megakaryocytes in the spleen and liver in a case of atypical myelosis, Folia haemat., 1930, xli, 55. Google Scholar58. SWENSONHOLZMAN PCGG: A discussion of generalized osteosclerosis with a report of an unusual case, Radiology, 1938, xxxi, 333. CrossrefGoogle Scholar59. KOENIGCULVER ECGJ: The value of roentgen therapy in carcinomatous metastases to bone, Radiology, 1943, xli, 38. CrossrefGoogle Scholar60. HUGGINS C: A summary of endocrine effects in advanced prostatic carcinoma, New York State Jr. Med., 1943, xliii, 519. Google Scholar61. JAFFE HL: Paget's disease of bone, Arch. Path., 1933, xv, 83. Google Scholar62. BELLEDSONHORNICK ALGNN: Characteristic bone and joint changes in compressed-air workers, Radiology, 1942, xxxviii, 698. CrossrefGoogle Scholar63. HUGGINSBLOCKSON CBH: Changes in outlying bone marrow accompanying a local increase of temperature within physiological limits, Jr. Exper. Med., 1935, lxiv, 253. Google Scholar64. TURNERMILLER DLFR: The preparation of concentrates of specific substances from urine and feces in leukemia, Jr. Biol. chem., 1943, cxlvii, 573. CrossrefGoogle Scholar65. SCHILLER W: Local myelopoiesis in myeloid leukemia, Am. Jr. Path., 1943, xix, 809. Google Scholar66. ERFJONES LAHW: Radio-phosphorus—an agent for the satisfactory treatment of polycythemia and its associated manifestations, Ann. Int. Med., 1943, xix, 587. Google Scholar67. RAKOFF AE: The diagnostic value of hormone assays, Med. Clin. North Am., 1942, xxvi, 1915. CrossrefGoogle Scholar68. ROSENTHAL N: A personal communication. Google Scholar69. CHURGWACHSTEIN JM: Osteosclerosis myelofibrosis and leukemia, Am. Jr. Med. Sci., 1944, ccvii, 141. CrossrefGoogle Scholar70. JACKSONPARKERLEMON HFHM: Agnogenic myeloid metaplasia of spleen; syndrome simulating other more definite hematologic disorders, New Eng. Jr. Med., 1940, ccxxii, 985. CrossrefGoogle Scholar71. STEINER PE: Multiple diffuse fibrosarcoma of bone, Am. Jr. Path., 1944, xx, 877. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Philadelphia, Pennsylvania*Presented at the Meeting of the Pathological Society at College of Physicians, Philadelphia, February 10, 1944. Received for publication March 11, 1944.From the Charlotte Drake Cardeza Foundation, the Department of Medicine and the Clinical Laboratories, Jefferson Medical College Hospital, Philadelphia. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByInfantile Myelofibrosis with Nephromegaly Secondary to Myeloid MetaplasiaAGNOGENIC MYELOFIBROSIS IN CHILDRENFamilial myelofibrosis.Eosinophilia, chloromas and a chromosome abnormality in a patient with a myeloproliferative syndromeReversal of myelofibrosis in advanced breast cancerAcute myelofibrosis and malignant hypercalcemiaMyelosclerosis in agnogenic myeloid metaplasiaMYELOID METAPLASIA IN DISSEMINATED VASCULAR DISEASEDas Myelofibrose-SyndromAndrogens and ErythropoiesisValue of the bone marrow biopsy in the diagnosis of metastatic carcinomaThe myeloproliferative disordersMetastatic carcinoma simulating agnogenic myeloid metaplasia and myelofibrosisBone changes in polycythaemia vera and myelosclerosisTransitions Among the Myeloproliferative DisordersROBERT M. GLASSER, M.D., RICHARD I. WALKER, M.D.AN AUTOPSY CASE OF PRIMARY OSTEOMYELOSCLEROSIS IN A 6-YEAR-OLD GIRLMyelofibrosis simulating acute leukaemia in a female infant with down’s syndromeTHE EFFECT OF TESTOSTERONE ON THE UPTAKE OF TRITIATED THYMIDINE BY THE BONE MARROW OF CHILDRENHaematological Changes in MalignancyMyelofibrosis and Myeloid LeukaemiaPolycythemiaStromal changes in leukaemic and related bone marrow proliferationsMyelofibrosis with Myeloid Metaplasia in Survivors of the Atomic Bomb in HiroshimaROBERT E. ANDERSON, M.D., TAKASHI HOSHINO, M.D., TSUTOMU YAMAMOTO, M.D.The Reticulin Content of Bone Marrow in Haematological DisordersStimulation of Erythropoiesis by Androgenic HormonesB. J. KENNEDY, M.D., F.A.C.P.Studies of the anemia of multiple myelomaAgnogenic Myeloid Metaplasia A Survey of Twenty-nine Cases and a Review of the LiteratureGEORGE S. NAKAI, M.D., CHARLES G. CRADDOCK, M.D., F.A.C.P., WILLIAM G. FIGUEROA, M.D.A Clinical and Pathological Study of Seventy Cases of MyelofibrosisJAMES A. PITCOCK, M.D., EDWARD H. REINHARD, M.D., F.A.C.P., BERTRAM W. JUSTUS, M.D., ROBERT S. MENDELSOHN, M.D.Differential Diagnosis of Massive Splenomegaly (Agnogenic Myeloid Metaplasia versus Chronic Granulocytic Leukemia)Red-Cell Production and Destruction in MyelosclerosisAPLASTIC ANEMIA: AN ANALYSIS OF 50 CASES*DANIEL N. MOHLER, M.D., BYRD S. LEAVELL, M.D., F.A.C.P.Increased Erythropoiesis Induced by Androgenic-Hormone TherapyDie Pathologie des Stoffwechsels der SchwermetalleAgnogenic myeloid metaplasiaMyelofibrosis and MyelosclerosisPrimary Myelofibrosis with Myeloid MetaplasiaMyelophthisic anemia in cancer of the breastDie Panmyelophthise und verwandte Zustände der KnochenmarksinsuffizienzHistological Studies of Carcinoma of the Prostate Treated by EstrogenHYPOPITUITARISM, HYPOGONADISM, AND ANÆMIA 1 November 1944Volume 21, Issue 5Page: 863-889KeywordsBoneBone marrowClinical laboratoriesFibrosisHospital medicine Issue Published: 1 November 1944 PDF DownloadLoading ...