tbuckley/cabot-search huggingface dataset:
Specific factor Xa inhibition reduces restenosis after balloon angioplasty of atherosclerotic femoral arteries in rabbits.
Authors: M Ragosta, L W Gimple, S D Gertz, C T Dunwiddie, G P Vlasuk, H L Haber, E R Powers, W C Roberts, I J Sarembock
Journal: Circulation (1994)

BACKGROUND Balloon angioplasty of atherosclerotic arteries results in activation of the coagulation cascade. Several coagulation factors, including factor Xa and thrombin, are mitogenic for vascular smooth muscle cells in vitro and thus may play a role in restenosis after balloon angioplasty. Specific inhibition of factor Xa can be achieved with recombinant antistasin (rATS) or tick anticoagulant peptide (rTAP). We hypothesized that inhibition of Xa would limit restenosis after balloon angioplasty in an atherosclerotic rabbit model. METHODS AND RESULTS Focal femoral atherosclerosis was induced by air desiccation injury and a high-cholesterol diet in 38 New Zealand White rabbits. Recombinant antistasin (n = 20 arteries) or rTAP (n = 14 arteries) was administered by intravenous bolus at the time of balloon angioplasty and followed by a 2-hour infusion; controls (n = 21 arteries) received bolus heparin alone (150 U/kg). Therapeutic prolongation of the activated partial thromboplastin time occurred, and antithrombotic drug levels were achieved in all animals. Luminal diameter in millimeters by quantitative angiography did not differ between treatment groups before (1.1 +/- 0.2 for controls, 1.1 +/- 0.2 for rATS, and 1.1 +/- 0.3 for rTAP) or after balloon angioplasty (1.5 +/- 0.3 for controls, 1.4 +/- 0.2 for rATS, and 1.4 +/- 0.2 for rTAP). At 28 days, treatment with factor Xa inhibitors tended to result in arteries with larger luminal diameter than controls (1.2 +/- 0.3 for rATS, 1.2 +/- 0.3 for rTAP versus 1.0 +/- 0.3 for control, P = .09 by one-way ANOVA). Restenosis, defined as reduction in angiographic luminal diameter (in mm) from 2 hours after angioplasty to 28 days after angioplasty was less in the rATS group than in controls (-0.2 +/- 0.1 versus -0.5 +/- 0.4, P &lt; .001) and tended to be less in the rTAP group (-0.3 +/- 0.2 versus -0.5 +/- 0.4, P = .07). Quantitative histopathological analysis showed less percent cross-sectional area narrowing by plaque in both rATS- and rTAP-treated arteries compared with controls (42 +/- 21%, 47 +/- 18%, and 63 +/- 14%, respectively; P &lt; .01 by one-way ANOVA). CONCLUSIONS We conclude that a 2-hour infusion of rATS or rTAP reduced angiographic restenosis and resulted in less luminal cross-sectional narrowing by plaque compared with controls.
On Bedside Teaching
Authors: Clifford W. Zwillich
Journal: Annals of Internal Medicine (1997)

Letters15 July 1997On Bedside TeachingClifford W. Zwillich, MDClifford W. Zwillich, MDUniversity of Colorado Health Sciences Center; Denver, CO 80220Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-127-2-199707150-00041 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:As I read LaCombe's article on bedside teaching [1]. I reflected that the changes in medical economics may resurrect “the good old days.” We academic internists have never been busier and now need to continuously document our real impact on patient care. There is no better way to do this than to round daily with the housestaff, at which time they present new and follow-up patients-at the bedside. We learn and teach each other as we go while communicating at the bedside with patients and families on a daily basis. We encourage nurses to join us, and ...References1. LaCombe MA. On bedside teaching. Ann Intern Med. 1997; 126:217-20. Google Scholar Author, Article, and Disclosure InformationAuthors: Clifford W. Zwillich, MDAffiliations: University of Colorado Health Sciences Center; Denver, CO 80220 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 15 July 1997Volume 127, Issue 2 Page: 172 Keywords Inpatients Nurses Patients ePublished: 15 August 2000 Issue Published: 15 July 1997 Copyright & PermissionsCopyright © 1997 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Congenital Aneurysm of Aortic Root with Fistula to Left Ventricle
Authors: R. IRVIN MORGAN, JOHN H. MAZUR
Journal: Circulation (1963)

Clinical and autopsy findings in a case of a congenital aneurysm of the base of the aorta involving the right sinus of Valsalva and communicating with the left ventricle are presented. The mechanism of development and possible etiologic factors are discussed.
Remarks ON PARALYSIS OF THE MOVEMENTS OF THE TRUNK IN HEMIPLEGIA, AND THE MUSCLES WHICH ARE AFFECTED
Authors: C. E. Beevor
Journal: BMJ (1909)

THis paper is intended to show that in some cases of hemiplegia-let us say left-the trunk muscles of each side act weakly when they take part in left-sided move- ments, and the same muscles act normally when they take part in right-sided movements; also that the movements of the trunk requiring bilateral action of muscles are very little, or not at all, affected.The question isdiscussed of the change in representation of one and the same group of muscles from one hemisphere to the other accordingly as they act in right-sided or left-sided movements; and also the question of the representation of movements re- quiring bilateral action of muscles in one or both hemispheres.The condition of the muscles of the trunk in hemiplegia and the question whether the movements in which they take part are paralysed or not has always presented con- siderable difficulty.In this paper I propose to describe a case of hemiplegia in which certain movements of the trunk were defective, so that, amongst other defects, the patient fell towards the hemiplegic side in trying to sit up; to analyse the muscles which take part in these de- fective movements; to compare these voluntary move- ments with those produced by morbid conditions in man, and with those elicited by cortical electric stimulation in animals in reference to representation of the movements in one or both hemispheres; and to describe the methods of ascertaining these defective movements in man.The patient was under my care at the Great Northern Central Hospital.According to the notes of Mr. Clayton, the house-physician, he was aged 52, married, a confectioner, but twenty years ago was a soldier in India.He had had gonor- rhoea, but there was no history of syphilis and no history of alcoholism.He had a fall from a bicycle a week before the onset, which was sudden, without loss of consciousness, and he lost power in the left arm and leg.On admission, there was no facial paralysis, the ocular movements were normal, the tongue when protruded (deviated slightly to the right, but he had more difficulty in putting the tip against the left cheek than the right.There was complete loss of power in the left upper and lower limbs, and the joints in the left lower limb were rather rigid.Sensation over the whole of the left half of the body and face and the left limbs was diminished to tactile and
A Randomized Trial of Endoscopic Biliary Sphincterotomy Using Pure-Cut Versus Combined Cut and Coagulation Waveforms
Authors: I NORTON, B PETERSEN, J BOSCO, D NELSON, P MEIER, T BARON, S LANGE, C GOSTOUT, D LOEB, M LEVY
Journal: Clinical Gastroenterology and Hepatology (2005)
Echocardiographic estimation of ventricular hypoplasia in complete atrioventricular canal.
Authors: S Mehta, S Hirschfeld, T Riggs, J Liebman
Journal: Circulation (1979)

Echocardiograms from 10 patients with complete atrioventricular canal (CAVC) were compared with autopsy specimens to determine the capabilities of echocardiography in identifying patients with ventricular hypoplasia. On the basis of echographic ventricular size, patients could be divided into three groups: 1) "balanced" CAVC patients had both increased right and left ventricular end-diastolic dimensions (RVED and LVED) and an increased RVED/LVED ratio; 2) "dominant left ventricular" CAVC patients had an increased LVED and small or normal RVED and a diminished RVED/LVED ratio; 3) "dominant right ventricular" CAVC patients had an increased RVED, but small LVED, and increased RVED/LVED. There was complete agreement between echographic ventricular dominance and pathologic findings. This study demonstrates that echocardiography may be valuable in assessing ventricular dominance in the presence of CAVC.
The Variable Spectrum of Echocardiographic Manifestations of the Mitral Valve Prolapse Syndrome
Authors: ANTHONY N. DEMARIA, JAMES F. KING, HUGO G. BOGREN, JAMES E. LIES, DEAN T. MASON
Journal: Circulation (1974)

The variety of echographic features associated with the mitral valve prolapse syndrome (MVPS) is not yet completely understood. Therefore, ultrasound recordings were obtained in 33 patients in whom mitral prolapse had been documented by biplane left ventricular cineangiography. Echographic abnormailities of the mitral leaflets during systole were recorded in 26/27 MVPS patients and 6/6 with ruptured chordae tendineae. In MVPS, the midsystolic mitral buckling, emphasized in early echocardiographic studies, was observed in only 12 patients. In our study, the most common aberrancy was abnormal pansystolic mitral motion in 14 patients, which in 12 was similar to the pansystolic bowing observed in all six patients with torn chordae. An additional echographic abnormality in MVPS was localized mitral collapse throughout systole in 10/14 patients with pansystolic prolapse; this finding was the most striking defect noted in five, in two of whom it was the only disturbance. Phonocardiography in MVPS showed typical midsystolic click and/or late systolic murmur in only 15/26 patients of whom ten had midsystolic mitral buckling. A variety of systolic clicks and/or murmurs occurred in the 14 patients with generalized bowing and/or localized collapse throughout systole on echocardiography. Thus, the mitral echographic spectrum of MVPS is comprised of three different abnormal patterns of systolic prolapse: buckling in midsystole, pansystolic bowing, and pansystolic collapse. These echocardiographic disorders commonly occur in the absence of classical auscultatory findings in MVPS and the most frequent abnormality on ultrasound is pansystolic bowing of both mitral leaflets.
MYOCARDIAL SCAR DIFFERENCES IN PATIENTS WITH ISCHEMIC CARDIOMYOPATHY AND SPONTANEOUS POLYMORPHIC OR MONOMORPHIC EVENTS DURING LONG-TERM FOLLOW-UP AFTER ICD IMPLANTATION
Authors: Peter Bernhardt, Sascha Stiller, Daniel Walcher, Wolfgang Rottbauer
Journal: Journal of the American College of Cardiology (2011)
Biochemical Correction of Very Long–chain Acyl-CoA Dehydrogenase Deficiency Following Adeno-associated Virus Gene Therapy
Authors: J. Lawrence Merritt, Tien Nguyen, Jan Daniels, Dietrich Matern, David B. Schowalter
Journal: Molecular Therapy (2009)

We report the development of a gene replacement strategy for very long-chain acyl-CoA dehydrogenase (VLCAD) deficiency. VLCAD is a mitochondrial enzyme involved in fatty acid beta-oxidation, a key step in energy production during times of fasting or stress. Deficiency of VLCAD classically presents as hepatic dysfunction, hypoglycemia, cardiomyopathy, rhabdomyolysis, and/or sudden death. While dietary therapy for VLCAD deficiency has proven beneficial in preventing some symptoms, a risk of metabolic catastrophic decompensation remains throughout life during times of increased energy demand. We designed a recombinant adeno-associated virus (AAV) expressing the human VLCAD gene (AAV8-hVLCAD). To demonstrate its in vivo activity, AAV8-hVLCAD was administered via the tail vein to VLCAD-knockout mice. A reduction in accumulated serum long-chain acylcarnitines and increased fasting tolerance judged on blood glucose concentrations were observed as of 11 days postinjections through >100 days. Western analysis of liver, skeletal muscle, and heart extracts using PEP1 anti-hVLCAD antibody revealed short-term hVLCAD expression in the liver and muscle and longer-term expression in heart. This demonstrates the ability of human VLCAD to correct the biochemical phenotype of VLCAD-deficient mice.
Toxic Psychosis Due to Quinacrine and Chloroquine
Authors: Oscar L. Sapp
Journal: JAMA (1964)

PSYCHOSIS that occurs during quinacrine hydrochloride administration has long been recognized as an infrequent but important toxic manifestation of this drug. It has only recently been noted that a toxic psychosis can be produced by chloroquine phosphate. Two patients have been seen at North Carolina Memorial Hospital who developed a toxic psychosis following administration of these antimalarial agents. <h3>Report of Cases</h3><h3>Case 1.—</h3> A 28-year-old white male was seen on Aug 27, 1960, shortly after returning from a visit to the Soviet Union. He had developed diarrhea five weeks previously and was having 10 to 12 stools daily. Marked tenesmus was present but no blood was observed. Physical examination showed no abnormalities. However, sigmoidoscopy revealed that the rectal and sigmoid mucosa was hyperemic and edematous but without ulceration or friability. Stool cultures revealed no enteric pathogens, but microscopic examination showed an extremely heavy infestation of<i>Giardia lamblia</i>and<i>Trichomonas hominis</i>
Cardiovascular and Cerebrovascular Events in Patients Treated for Human Immunodeficiency Virus Infection
Authors: Samuel A. Bozzette, Christopher F. Ake, Henry K. Tam, Sophia W. Chang, Thomas A. Louis
Journal: New England Journal of Medicine (2003)

Metabolic abnormalities associated with human immunodeficiency virus (HIV) infection, including dysglycemia and hyperlipidemia, are increasingly prevalent, and there is concern about the possibility of an association with accelerated cardiovascular and cerebrovascular disease.
Conducting clinical research in the new NHS
Authors: E Rous
Journal: BMJ (1994)

skills will be applied in an increasingly sophisticated way to solve everyday clinical problems.The skills learnt will include critical appraisal, self directed leaming, and group working besides the theory and applications of epidemiology and biostatistics.As our medical school revises the later years of the undergraduate curriculum we look to our clinical colleagues to put the principles of evidence based medicine into practice so that we train a new generation of doctors who will be practising more of the science, as well as the art, of medicine and who will contribute to the knowledge based health service that Smith envisages.
Abstract 4381: Biochemical and histopathological evaluation of mice exposed to functionalized single-walled carbon nanotube
Authors: Anita K. Patlolla, Britney McGinnis, Paul Tchouwou
Journal: Cancer Research (2010)

Abstract Single walled carbon nanotubes (SWCNTs) with their unique physicochemical properties, have many potential new applications in medicine and industry such as sensors, implants or delivery systems. The biomedical application of single-walled carbon nanotubes requires a fundamental understanding of their fate and toxicological profile after administration. However, the toxicity of SWCNT is barely known when they are introduced into the blood circulation, which is especially vital for their biomedical applications. The aim of this study was to conduct biochemical analysis to determine the effect of purified/functionalized single-walled carbon nanotube (SWCNT) on the induction of reactive oxygen species (ROS), activities of specific liver enzymes such as aminotransferases (GOT/GPT), alkaline phosphatases (ALP), concentration of lipid hydro peroxide (LPO) and histopathology of liver, which may be useful as biomarkers of hepatotoxicity and oxidative stress. Three groups of five male mice each weighing approximately 30 + 2 g were injected intraperitoneally once a day for five days with doses of 0.25, 0.5, 0.75 mg/kg BW of functionalized SWCNT. A control group was also made of 5 mice. At the end of the experiment, samples were collected following standard protocols. Exposure to functionalized SWCNT was found to show an increase in the induction of ROS, activities of serum amino-transferases (GOT/GPT), alkaline phosphatases (ALP) and concentration of lipid hydro peroxide compared to control. Histopathological evaluation of liver showed a statistically significant effect in the liver tissue (hepatic fibrosis) compared to controls. The results demonstrate that purified functionalized SWCNT was able to induce hepatotoxicity and oxidative stress. Our result does not imply that CNTs should be banned from use but more in vivo studies with histopathological characterization should be designed in biological application. Keywords: Single walled carbon nanotube, reactive oxygen species, lipid hydroperoxide, serum aminotransferases, alkaline phosphatases, Swiss-Webster mice, histopathology, hepatotoxicity. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 101st Annual Meeting of the American Association for Cancer Research; 2010 Apr 17-21; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2010;70(8 Suppl):Abstract nr 4381.
Taller women are at greater risk of recurrent venous thromboembolism: The Iowa Women's Health Study
Authors: Pamela L. Lutsey, Aaron R. Folsom
Journal: American Journal of Hematology (2012)

Venous thromboembolism (VTE) recurs frequently. Greater height is associated with increased risk of incident VTE, but it is unclear whether height is related to risk of VTE recurrence. Recurrent VTE is associated with substantial morbidity and mortality, thus identifying individuals at greatest risk of experiencing a recurrent event, who may benefit from extended anticoagulant therapy, is vitally important. Using data from the Iowa Women,s Health Study, we explored whether greater height was associated with increased risk of VTE recurrence.Among 1,691 women who experienced an initial VTE event, 286(16.9%) experienced a recurrent event. Risk of recurrence was 76%(95% CI: 16% -186%) higher among women >66 inches [168 cm] tall relative to those ≤62 inches [158 cm] tall, after adjustment for age and waist circumference. Future research should evaluate whether body height improves clinical prediction of VTE recurrence risk.
Biologically based pesticide dose estimates for children in an agricultural community.
Authors: R A Fenske, J C Kissel, C Lu, D A Kalman, N J Simcox, E H Allen, M C Keifer
Journal: Environmental Health Perspectives (2000)

Current pesticide health risk assessments in the United States require the characterization of aggregate exposure and cumulative risk in the setting of food tolerances. Biologic monitoring can aggregate exposures from all sources and routes, and can integrate exposures for chemicals with a common mechanism of action. Its value was demonstrated in a recent study of organophosphorus (OP) pesticide exposure among 109 children in an agricultural community in Washington State; 91 of the children had parents working in agriculture. We estimated individual OP pesticide doses from urinary metabolite concentrations with a deterministic steady state model, and compared them to toxicologic reference values. We evaluated doses by assuming that metabolites were attributable entirely to either azinphos-methyl or phosmet, the two OP pesticides used most frequently in the region. Creatinine-adjusted average dose estimates during the 6- to 8-week spraying season ranged from 0 to 36 microg/kg/day. For children whose parents worked in agriculture as either orchard applicators or as fieldworkers, 56% of the doses estimated for the spray season exceeded the U.S. Environmental Protection Agency (EPA) chronic dietary reference dose, and 19% exceeded the World Health Organization acceptable daily intake values for azinphos-methyl. The corresponding values for children whose parents did not work in agriculture were 44 and 22%, respectively. The percentage of children exceeding the relevant reference values for phosmet was substantially lower (< 10%). Single-day dose estimates ranged from 0 to 72 microg/kg/day, and 26% of these exceeded the EPA acute reference dose for azinphos-methyl. We also generated dose estimates by adjustment for total daily urine volume, and these estimates were consistently higher than the creatinine-adjusted estimates. None of the dose estimates exceeded the empirically derived no-observable-adverse-effect levels for these compounds. The study took place in an agricultural region during a period of active spraying, so the dose estimates for this population should not be considered representative of exposures in the general population. The findings indicate that children living in agricultural regions represent an important subpopulation for public health evaluation, and that their exposures fall within a range of regulatory concern. They also demonstrate that biologically based exposure measures can provide data for health risk evaluations in such populations.
Nonvisualization of Sterile Surgical Incisions with lndium-111 Labeled Leukocytes
Authors: HANI ABDEL-NABI, GEORGE H. HINKLE, JOHN O. OLSEN
Journal: Clinical Nuclear Medicine (1985)

The localization of In-111 labeled leukocytes (WBCs) in recent surgical incisions was studied in 18 patients. In-111 WBC images correlated well with culture results and clinical findings. No accumulation of In-111 WBCs was detected at the site of noninfected incisions in nine patients. In-111 WBCs did accumulate at incision sites in nine patients with infected surgical incisions. These results indicate that In-111 WBC study can accurately distinguish between normal healing and infection of recent surgical incisions.
PECULIAR SYMPTOMS FOLLOWING A RADICAL OPERATION.
Authors: GEORGE F. COTT
Journal: JAMA (1905)

<h3>Patient.</h3> —Dr. N. C. H., Buffalo, N. Y., consulted me during her student years regarding a fetid discharge from the left ear. I found a large perforation in the drumhead and carious bone wherever the probe reached. She received local treatment four weeks, when the discharge stopped. After several years she called on me again, complaining of unbearable pain in the ear. She was then under the care of Dr. Buswell for myocarditis. She had a pronounced regurgitant murmur and often had severe pain in the region of the heart; this occasionally kept her awake until 4 or 5 o'clock in the morning, and when that did not trouble her the pain in the ear would take its place. I consulted Dr. Buswell and was advised that he would get her ready for operation. I put this off as long as possible, but, as the pain in the ear became