THE QUANTITATIVE SEROLOGIC TEST FOR SYPHILIS; ITS VARIABILITY, USEFULNESS IN ROUTINE DIAGNOSIS, AND POSSIBLE SIGNIFICANCE; A STUDY OF 1665 CASES
Authors: Joseph Earle Moore, Harry Eagle
Journal: Annals of Internal Medicine (1941)

Article1 April 1941THE QUANTITATIVE SEROLOGIC TEST FOR SYPHILIS; ITS VARIABILITY, USEFULNESS IN ROUTINE DIAGNOSIS, AND POSSIBLE SIGNIFICANCE; A STUDY OF 1665 CASESJOSEPH EARLE MOORE, M.D., HARRY EAGLE, M.D.JOSEPH EARLE MOORE, M.D.Search for more papers by this author, HARRY EAGLE, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-14-10-1802 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe complement fixation reaction for the diagnosis of syphilis was introduced by Wassermann, Neisser, and Bruck in 1906; and the foundation of modern flocculation technics was laid by Michaelis in 1907. These originators used a fixed amount of patient's serum, a qualitative procedure still used in most serodiagnostic laboratories. The amounts of patient's serum used in the standard qualitative diagnostic tests commonly employed in the United States are shown in table 1. Because of the widely different typesof "antigen" suspension used in these tests, and because the serum: antigen ratio rather than the absolute amount of serum is the...Bibliography1. See first footnote, table 1. Google Scholar2. BOAS H: Die Wassermannsche Reaktion bei aktiven und inaktiven Sera, Berl. klin. Wchnschr., 1909, xlvi, 400. Google Scholar3. EAGLE H: Laboratory diagnosis of syphilis, 1937, C. V. Mosby Co., St. Louis, Mo., p. 86. Google Scholar4. NOGUCHI H: Die quantitative Seite der Serodiagnostik der Syphilis, Ztschr. f. Immunitätsforsch. u. exper. Therap., 1911, ix, 6. Google Scholar5. GEHRMANNWESENERROMAN AJAM: The prognostic and diagnostic value and interpretation of the quantitative Wassermann reaction, Ill. Med. Jr., 1921, xxxix, 212. Google Scholar6. 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Inform., 1939, xx, 255. Google Scholar19. CROSBYCAMPBELL ELAM: The quantitatively titered serologic test in early syphilis and its response to treatment, Am. Jr. Syph., Gonor., and Ven. Dis., 1941. (In press.) Google Scholar20. KEMPCHESNEYPOOLE JEAMOK: The Wassermann test in normal and syphilitic rabbits, Bull. Johns Hopkins Hosp., 1926, xxxix, 132. Google Scholar21. MOOREKEMP JEJE: The Wassermann reaction in treated early syphilis, Bull. Johns Hopkins Hosp., 1926, xxxix, 36. Google Scholar22. MOOREHARDYROBINSONEAGLE JESMHMH: The response of the quantitatively titered Wassermann test in early syphilis to treatment with five different arsenical drugs, Am. Jr. Syph., Gonor. and Ven. Dis., 1926, xx, 503. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Baltimore, Maryland*Received for publication October 5, 1940.From the Syphilis Division of the Medical Clinic of the Johns Hopkins University and Hospital, and the United States Public Health Service. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byAssociation between neurosyphilis and diabetes mellitus: Resurgence of an old problem 神经梅毒与糖尿病的关系：“旧事”再现REVIEW: Neurosyphilis: A Historical Perspective and ReviewKlassische Serologie der SyphilisDie Mittelbaren und Sekundären Folgeerscheinungen der Antigen-Antikörper-ReaktionenTHE USES AND LIMITATIONS OF THE SERUM TESTS FOR SYPHILIS 1 April 1941Volume 14, Issue 10Page: 1802-1814KeywordsAntigensHospitalsMedical servicesSyphilis ePublished: 1 December 2008 Issue Published: 1 April 1941 PDF downloadLoading ...