tbuckley/cabot-search huggingface dataset:
Does the energy expenditure of patients with COPD reflect their time spent walking and intensity of walking in daily life
Authors: Thaís Sant'Anna, Carlos Augusto Camillo, Renato Vitorasso, Anaisa Cortez Vercese, Victoria Cristina Escobar, Nidia Aparecida Hernandes, Fabio Pitta
Journal: European Respiratory Journal (2012)

Introduction: The level of physical activity in daily life (PADL) is frequently expressed by energy expenditure (EE) measurement. However, patients with chronic obstructive pulmonary disease (COPD) often present high EE due to increased work of breathing, systemic inflammation and other factors. Thus, EE might not be a good outcome to characterize PADL in this population. Aim: To verify the influence of time spent walking, movement intensity and other PADL variables on EE of patients with moderate to severe COPD. Methods: The PADL of 53 patients (35men, 66±9yrs, FEV1 38±15%pred) was evaluated by two activity monitors (DynaPort MiniMod and SenseWear). The DynaPort mainly registers time spent walking (TW), standing, sitting, lying (TL), and movement intensity during walking (MI). The SenseWear mainly registers total energy expenditure (TEE) and active energy expenditure (AEE). Patients wore both motion sensors in daily life during two consecutive weekdays (12hs/day). Results: Only TW (r=0.41) and TL (r= -0.31) significantly explained TEE (r2=0.40, p
CIRCUMSCRIBED AND ISOLATED BRONCHIECTASIS
Authors: John Chapman, John A. Wiggins
Journal: Annals of Internal Medicine (1941)

Article1 May 1941CIRCUMSCRIBED AND ISOLATED BRONCHIECTASISJOHN CHAPMAN, A.M., M.D., JOHN A. WIGGINS, M.D.JOHN CHAPMAN, A.M., M.D.Search for more papers by this author, JOHN A. WIGGINS, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-14-11-2047 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptBronchiectasis is generally thought of as a widespread and diffuse disease involving the greater part of a lobe, or perhaps several lobes. We have been unable to find references to limited or circumscribed dilatations in American literature and know of but two cases which have been reported in foreign publications.2 These two cases showed, one a dilatation involving the axillary branch of the right lower lobe and the other a dilated pectoral branch of the right upper bronchus. Both were of a saccular variety. It was not stated whether or not the contralateral side had been injected.In searching the...Bibliography1. AMBERSON JB: Personal communication. Google Scholar2. HALL AS: Two examples of localized bronchiectasis, Tubercle, 1938, 278. CrossrefGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Sanatorium, Texas*Received for publication November 9, 1939. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byLOCALIZED BRONCHIECTASIS SIMULATING PULMONARY NEOPLASMS*BENJAMIN SCHWARTZ, M.D., HARRY L. KATZ, M.D.Bronchiectasis and its surgical considerations 1 May 1941Volume 14, Issue 11Page: 2047-2057KeywordsBronchiectasis ePublished: 1 December 2008 Issue Published: 1 May 1941 PDF downloadLoading ...
BAX protein is not expressed by basal cell carcinomas
Authors: None Rossen, None Karabulut Thorup, None Hou-Jensen, None Krag Jacobsen
Journal: British Journal of Dermatology (1998)

BAX and related proteins encoded by the BCL2 gene family are involved in the regulation of apoptosis. BAX is an apoptosis‐promoting protein. The slow growth of basal cell carcinoma (BCC) has so far been explained by a high apoptotic activity. We investigated immunohistochemically 27 BCCs for expression of the apoptosis‐promoting BAX protein. BCC did not express detectable amounts of BAX immunohistochemically. The results indicate that apoptosis in BCC does not involve BAX protein. We propose that the apoptotic pathway in BCC is regulated by either less common members of the BCL2 gene family or bypasses the regulation of the BCL2 gene family.
Comparison of ex vivo optical coherence tomography with conventional frozen-section histology for visualizing basal cell carcinoma during Mohs micrographic surgery
Authors: D. Cunha, T. Richardson, N. Sheth, G. Orchard, A. Coleman, R. Mallipeddi
Journal: British Journal of Dermatology (2011)

Mohs micrographic surgery offers high cure rates of nonmelanoma skin cancers with optimal sparing of normal tissue. However, it is generally more time-consuming and labour-intensive than traditional surgery. Optical coherence tomography (OCT) is an emergent technology that has the potential to diagnose basal cell carcinoma (BCC) in vivo.To compare the efficiency and accuracy of ex vivo OCT with frozen-section histology for identifying BCC in Mohs surgery.Thirty-eight patients were enrolled. After the stages were taken, images were captured with an OCT microscope and subsequently processed for standard frozen sections.In total, 75 sections were scanned and the mean time to produce one OCT image was 7 min. In four of 26 positive haematoxylin-eosin sections and 23 of 49 negative sections, there was a good correlation with OCT images. The sensitivity and specificity were 19% and 56%, respectively.It is possible to identify BCC with ex vivo OCT and this is more rapidly obtained than with haematoxylin-eosin frozen sections. However, tumour visualization in OCT was disappointing. Practical benefit may be obtained by optimizing this technology and combining it with other new diagnostic tools.
New Rule Proposed for Home Drug Abuse Test Kits
Authors: Stuart L. Nightingale
Journal: JAMA (1998)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
A Mother's Voice
Authors: F Nenner
Journal: JAMA (1999)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Abstract 15173: Left Atrial Wall Deformation Assessed by 3-Dimensional Speckle Tracking Imaging is a Useful Method in Assessing Left Ventricular Filling Pressure
Authors: Kazuaki Wakami, Shohei Kikuchi, Noriyuki Ikehara, Toshihiko Goto, Tomonori Sugiura, Hidekatsu Fukuta, Tomomitsu Tani, Nobuyuki Ohte
Journal: Circulation (2014)

In the subset with the ratio of early mitral inflow velocity (E) to early mitral annulus velocity (e’), that is the E/e’ ratio, ranged from 8 to 15, the E/e’ has been considered not to be able to precisely assess left ventricular (LV) filling pressure. Several previous studies have reported that elevated left atrial (LA) pressure deteriorates LA wall distensibility. Three-dimensional speckle tracking imaging (3D-STI) technique enables us to assess LA wall area strain (AS). Accordingly, we investigated whether the elevated LV filling pressure could be predicted by measuring the LA-AS. Methods: Study subjects were 69 patients with sinus rhythm who underwent diagnostic cardiac catheterization and 3D-STI (ArtidaTM, Toshiba) on the same day. Twenty-two of them had prior myocardial infarction, while the remaining 47 had no localized LV wall motion abnormality. The temporal changes of global LA-AS were drawn offline using an echo image analyzer (Ultra-ExtendTM, Toshiba). Both the peak LA-AS value at LV end-systo...
Other Election Health Matters
Authors: Mike Mitka
Journal: JAMA (2004)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Abstract 4787: Half of Patients with Severe Symptomatic Aortic Stenosis Do Not Undergo Aortic Valve Replacement
Authors: Sarah K Gualano, Derrick Siao, Steven E Girard, Claire Duvernoy, Benjamin D McCallister, David S Bach
Journal: Circulation (2008)

Although aortic stenosis (AS) is common, little data exist about the rate of aortic valve replacement (AVR) in patients with severe symptomatic AS. Many patients with severe symptomatic AS do not undergo AVR. Echocardiography databases for 3 large tertiary centers were searched for patients in 2005 with severe AS (mean gradient ≥ 40 mmHg, valve area of &lt; 1.0 cm 2 , or overall clinical assessment of severe AS). Records were reviewed for symptoms, referral, surgical AVR, and outcome. Operative risk was calculated using the logistic EuroSCORE. Four hundred thirteen patients had an echocardiogram with severe AS; 44 were excluded based on additional testing or inadequate medical records. Of the remaining 368 patients, 188 (51%) underwent AVR, and 191 (49%) and were un-operated. Of 191 un-operated patients, 126 (66%, 34% of total) had symptoms consistent with AS, 182 (95%) were referred to cardiology, but 75 of 126 (60%) un-operated symptomatic patients were not referred for surgical assessment. Among un-operated symptomatic patients, operative risk was &lt; 5% in 31 (25%) and &lt; 10% in 59 (47%). The prevalence of un-operated patients was similar between institutions. Decisions not to operate most commonly were based on co-morbidities, patient preference, symptoms due to other conditions, and unrecognized AS. With an average follow-up of 13.9 ± 9.8 months, 52 of 191 (27%) un-operated patients died. Half of patients with severe symptomatic AS do not undergo AVR, with similar findings in multiple tertiary care environments. Some patients with severe symptomatic AS may be inappropriately denied access to potentially life-saving therapy.
Regulation of vasculogenesis and angiogenesis by EphB/ephrin-B2 signaling between endothelial cells and surrounding mesenchymal cells
Authors: Yuichi Oike, Yasuhiro Ito, Koichi Hamada, Xiu-Qin Zhang, Keishi Miyata, Fumio Arai, Tomohisa Inada, Kimi Araki, Naomi Nakagata, Motohiro Takeya, Yaz Y. Kisanuki, Masashi Yanagisawa, Nicholas W. Gale, Toshio Suda
Journal: Blood (2002)
519. Minimally Invasive Strategies for Administration of Genetically-Modified Glia to the Contused Spinal Cord
Authors: Raquel M. Walton, Deborah J. Watson, John H. Wolfe
Journal: Molecular Therapy (2004)

MPS VII is a lysosomal storage disease caused by β-glucuronidase (GUSB) deficiency. Multiple organ failure and mental retardation succeed the accumulation of undegraded glycosaminoglycans in cellular lysosomes. Treatment of the neurologic component is challenging because GUSB does not usually cross the blood-brain barrier. One strategy to reverse lysosomal storage throughout the CNS is to engraft multiple cellular sources of enzyme in the developing brain. Neural progenitor cells (NPCs) show potential as therapeutic gene delivery vehicles in the CNS. They are self-renewing and multipotent with the capacity to differentiate into both neurons and glia. Enzyme secreted from these cells can be taken up by neighboring cells, creating overlapping “spheres of correction” throughout the neuraxis. Murine NPCs have successfully been used to reverse CNS lysosomal storage lesions in murine models of MPS VII. However, it is uncertain whether this success can translate to a child's brain that is architecturally more complex and 1000-fold larger. The existence of a canine model of MPS VII affords the opportunity to test the therapeutic potential of NPCs in a brain that is structurally similar to a human child's and is only 10-fold smaller in scale.
Antihistamine‐resistant urticaria factitia successfully treated with anti‐immunoglobulin E therapy
Authors: K. Krause, E. Ardelean, B. Keßler, M. Magerl, M. Metz, F. Siebenhaar, K. Weller, M. Worm, T. Zuberbier, M. Maurer
Journal: Allergy (2010)
Abstract 20318: Elevated Levels of Lipoprotein(a) Are Causally Associated With Chronic Kidney Disease
Authors: Jennie Lin, Wei Zhao, Daniel J Rader, Muredach Reilly, Danish Saleheen
Journal: Circulation (2014)

Introduction: It remains unknown whether circulating Lipoprotein(a) [Lp(a)] levels and isoform size of apolipoprotein(a) [apo(a)] bound to Lp(a) are causally relevant to CKD. Methods: We conducted measurements for Lp(a) levels and apo(a) isoform size in 10,765 participants enrolled in the Pakistan Risk of Myocardial Infarction Study (PROMIS). 1,420 participants were diagnosed to have CKD based on estimated glomerular filtration rate (eGFR) less than 60 mL/min/1.73 m2. Lp(a) levels were measured using a high-sensitivity immunoturbidimetric assay, whereas apo(a) isoform size was measured using a validated qPCR assay that assesses CNV repeats in the exon-4 of the LPA gene. We compared the Odds Ratio (OR) for CKD conferred by observed increases in Lp(a) levels with equivalent differences caused by genetic variation due to rs10455872, a variant known to regulate Lp(a) levels. Data on 72,369 participants were available for rs10455872 in association with CKD through combined analyses of PROMIS and the CKDGEN con...
Abstract P168: Vitamin D Status does not influence Bone Density in Africans
Authors: Caroline K Thoreson, Michelle Y O'Connor, Madia Ricks, Stephanie T Chung, James C Reynolds, Anne E Sumner
Journal: Circulation (2014)

Without regard to race, the Institute of Medicine states that to protect bone health vitamin D, measured as 25(OH)D, should be &gt;20 ng/mL while levels of 12-19 ng/mL are inadequate and levels of &lt;12 ng/mL are deficient. However, even when 25(OH)D levels are low, bone mineral density (BMD) is not compromised in African-Americans. The relationship of 25(OH)D levels to BMD in Africans is unknown. Therefore 78 African immigrants to the United States (77% male, median age 35y, age range 22-63y (95% CI: 36, 40)) had 25(OH)D levels and dual-energy X-ray absorptiometry (DXA) scans. Distribution of 25(OH)D levels by quartile was determined (Fig. 1). The distribution of whole body BMD across quartiles of 25(OH)D was assessed (Fig. 2). Median 25(0H)D levels was 21 ng/mL (95% CI: 20, 23) with 47% having 25(OH)D&lt;20 ng/mL and 8% having 25(OH)D &lt;12 ng/mL. BMD did not change across quartiles of 25(OH)D (Fig. 2). Spearman correlation between BMD and 25(OH)D was r =0.1, P=0.5. As there was no relationship between vitamin D levels and BMD, low 25(OH)D levels are not a predictor of low bone density in Africans.
Health professions and risk of sporadic Creutzfeldt–Jakob disease, 1965 to 2010
Authors: E Alcalde-Cabero, J Almazán-Isla, J P Brandel, M Breithaupt, J Catarino, S Collins, J Haybäck, R Höftberger, E Kahana, G G Kovacs, A Ladogana, E Mitrova, A Molesworth, Y Nakamura, M Pocchiari, M Popovic, M Ruiz-Tovar, A L Taratuto, C van Duijn, M Yamada, R G Will, I Zerr, J de Pedro Cuesta
Journal: Eurosurveillance (2012)

Binary file ES_Abstracts_Final_ECDC.txt matches
The Gift Relationship: From Human Blood to Social Policy, by Richard M Titmuss Man and Wife: Richard and Kay Titmuss My Parents' Early Years, by Ann Oakley
Authors: R. Porter
Journal: BMJ (1997)

Richard M Titmuss Original edition with new chapters, eds Ann Oakley, John Ashton LSE Books, £14.99, pp 345 ISBN 0 7530 12014

Ann Oakley Flamingo, £7.99, pp 288 ISBN 0 00 655013 4

With the eclipse of the politics of state socialism, Richard Titmuss has ceased to be a household name. But, for the postwar generation, he was one of the intellectual pillars of the welfare state, combining mastery of the statistics of poverty, inequality, and ill health with an impassioned philosophy of social justice. The Gift Relationship (1970), his last major work and now available once more in a welcome updated reprint, is vintage Titmuss: the model of the British National Blood Transfusion Service is commended not merely because giving rather than selling blood fosters social altruism but because (as his abundant figures show)it also makes for an …
Abstract 763: Resistance to cabazitaxel is associated with <i>ABCB1</i>/P-glycoprotein activation, alterations in β-tubulin content and dynamics, reduced BRCA1, and a mesenchymal phenotype in MCF-7 human breast cancer variants
Authors: George E. Duran, Yan C. Wang, E Brian Francisco, Francisco J. Martinez, Branimir I. Sikic
Journal: Cancer Research (2014)

Abstract In order to identify determinants of cellular response to this new taxane, we derived a resistant variant from the MCF-7 human breast cancer cell line by stepwise selection in cabazitaxel. The 33-fold resistance to cabazitaxel in this variant, MCF-7/CTAX, was associated with ABCB1/P-glycoprotein (P-gp) activation, but also 3-fold residual resistance to taxanes after modulation with the P-gp inhibitor PSC-833, 2 μM. Another variant was established by co-selecting in the presence of PSC-833 (MCF-7/CTAX-P). This variant was negative for ABCB1 transcripts and accumulated parental levels of rhodamine-123, BODIPY-labeled paclitaxel and [3H]-docetaxel, indicating that the taxane resistance (9-fold) observed in this cell line is not mediated by transporters. However, we observed a 34% reduction in bound fluorescent-labeled paclitaxel in MCF-7/CTAX-P relative to parental controls by flow cytometry. These cells are hypersensitive to depolymerizing agents (vincas and colchicine) indicating a change in tubulin dynamic instability, and we observed reduced baseline tubulin polymer in untreated MCF-7/CTAX-P cells, and impaired tubulin polymerization in response to taxane exposure (cabazitaxel or docetaxel) relative to MCF-7 parental cells. Quantitative PCR and immunoblotting confirmed elevated levels of the class III (TUBB3) β-tubulin isotype in both MCF-7/CTAX and MCF-7/CTAX-P. Reduced BRCA1 content was observed in both MCF-7 variants, which could affect taxane response via the regulation of the mitotic spindle checkpoint. Gene silencing with specific siRNAs confirmed that reduced TUBB3 sensitizes cells to cabazitaxel, and reduced BRCA1 results in taxane resistance. In addition, altered epithelial-mesenchymal transition markers (elevated Vimentin, reduced E-cadherin) are associated with cabazitaxel resistance in these MCF-7 variants. In summary, cabazitaxel resistance mechanisms include MDR (although at a lower level than paclitaxel and docetaxel), and alterations in microtubule dynamicity, as manifested by higher expression of TUBB3, decreased BRCA1, and by the induction of EMT. Citation Format: George E. Duran, Yan C. Wang, E Brian Francisco, Francisco J. Martinez, Branimir I. Sikic. Resistance to cabazitaxel is associated with ABCB1/P-glycoprotein activation, alterations in β-tubulin content and dynamics, reduced BRCA1, and a mesenchymal phenotype in MCF-7 human breast cancer variants. [abstract]. In: Proceedings of the 105th Annual Meeting of the American Association for Cancer Research; 2014 Apr 5-9; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2014;74(19 Suppl):Abstract nr 763. doi:10.1158/1538-7445.AM2014-763
La Pia de Tolommei
Authors: M. Therese Southgate
Journal: JAMA (2003)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal