IDIOPATHIC HYPOPARATHYROIDISM: REPORT OF A CASE
Authors: R W NAEF, E H ADLE
Journal: Annals of Internal Medicine (1959)

Case Reports1 February 1959IDIOPATHIC HYPOPARATHYROIDISM: REPORT OF A CASERICHARD W. NAEF, M.D., EMIR H. ADLE, M.D.RICHARD W. NAEF, M.D.Search for more papers by this author, EMIR H. ADLE, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-50-2-495 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptINTRODUCTIONIdiopathic hypoparathyroidism is a relatively rare disease. In 1952 Steinberg and Waldron1 collected 51 cases from the literature and added one of their own. They further reported that, out of 213,025 patients admitted to Queen's Hospital over a period of 15 years (1935-1950), only one was diagnosed as idiopathic hypoparathyroidism. Wise and Hart2 (1952) found only three such cases in a 10-year survey at the King's County Hospital, where the yearly admission rate is 62,000.Recent reviews of the clinical features of idiopathic hypoparathyroidism are found in the papers of Grant3(1953), Sugar4(1953), de Mowbray5(1953) and Robinson...Bibliography1. SteinbergWaldron HBR: Idiopathic hypoparathyroidism: an analysis of 52 cases, including report of a new case, Medicine 31: 133, 1952. CrossrefMedlineGoogle Scholar2. WiseHart BLJC: Idiopathic hypoparathyroidism and pseudohypoparathyroidism: observations on the electroencephalogram in hypocalcemia, Arch. Neurol. and Psychiat. 68: 78, 1952. CrossrefGoogle Scholar3. Grant DK: Papilledema and fits in hypoparathyroidism, Quart. J. Med. 22: 243, 1953. MedlineGoogle Scholar4. Sugar O: Central neurological complications of hypoparathyroidism, Arch. Neurol. and Psychiat. 70: 86, 1953. CrossrefMedlineGoogle Scholar5. de Mowbray RR: Discussion on the physiology and clinical disorders of the parathyroid glands: hypoparathyroidism, Proc. Roy. Soc. Med. 46: 296, 1953. MedlineGoogle Scholar6. RobinsonCarmichaelCumings PKEAJN: Idiopathic hypoparathyroidism. A study of three cases, Quart. J. Med. 23: 383, 1954. MedlineGoogle Scholar7. PerlmutterEllisonNorsaKantrowitz MRRLAR: Idiopathic hypoparathyroidism and Addison's disease, Am. J. Med. 21: 634, 1956. CrossrefMedlineGoogle Scholar8. WhitakerLandingEsselbornWilliams JABHVMRR: The syndrome of familial juvenile hypoadrenocorticism, hypoparathyroidism and superficial moniliasis, J. Clin. Endocrinol. 16: 1374, 1956. CrossrefGoogle Scholar9. Leonard MF: Chronic idiopathic hypoparathyroidism with superimposed Addison's disease in a child, J. Clin. Endocrinol. 6: 493, 1946. CrossrefGoogle Scholar10. Mortell EJ: Idiopathic hypoparathyroidism with mental deterioration: effect of treatment on intellectual function, J. Clin. Endocrinol. 6: 266, 1946. CrossrefGoogle Scholar11. Simpson JA: The neurological manifestations of idiopathic hypoparathyroidism, Brain 75: 76, 1952. CrossrefMedlineGoogle Scholar12. GottaOdoriz HJB: The electroencephalogram in hypoparathyroidism with tetany and epilepsy, J. Clin. Endocrinol. 8: 674, 1948. CrossrefGoogle Scholar13. Gotta H: Tetany and epilepsy, Arch. Neurol. and Psychiat. 66: 714, 1951. CrossrefGoogle Scholar14. GrieveSchamoth SL: Idiopathic hypoparathyroidism, South African M. J. 29: 232, 1955. MedlineGoogle Scholar15. Odorizdel CastilloManfredide la Balze JBEBJFFA: Parathyroid insufficiency and the human electroencephalogram, J. Clin. Endocrinol. 4: 493, 1944. CrossrefGoogle Scholar16. KlotzStroun HPJ: Les anomalies de l'électro-encephalogramme dans 85 cas de tétanie chronique, Semaine d. hôp. Paris 31: 431, 1955. MedlineGoogle Scholar17. SchulmanRatner JLH: Idiopathic hypoparathyroidism with bony demineralization and cardiac decompensation, Pediatrics 16: 848, 1955. MedlineGoogle Scholar18. GreeneSwanson JALW: Psychosis in hypoparathyroidism; with a report of five cases, Ann. Int. Med. 14: 1233, 1941. LinkGoogle Scholar19. Gsell O: Chronische idiopathische Tetanie (mit Psoriasis) (hypoparathyreoider Kretinismus), Deutsche med. Wchnschr. 75: 1117, 1950. CrossrefMedlineGoogle Scholar20. Burghardt E: Idiopathische, nichtarteriosklerotische, intrazerebrale Gefässverkalkung und hypoparathyreogene Kalkstoffwechselstörung, Wien. Ztschr. inn. Med. 34: 52, 1953. MedlineGoogle Scholar21. Pick A: Vorlaufige Mitteilung zur Pathologie der Tetanie, Neurol. Centralbl. 21: 578, 1902. Google Scholar22. Fahr T: Idiopathische Verkalkung der Hirngefasse, Zentralbl. f. allg. Path. u. path. Anat. 50: 129, 1930. Google Scholar23. WagnerSlagerTucker JAVTL: Hypoparathyroidism with cerebral calcification. I. Report of a case, Bull. School Med. Univ. Maryland 39: 102, 1954. MedlineGoogle Scholar24. EatonHaines LMSF: Parathyroid insufficiency with symmetrical cerebral calcification: report of three cases, in one of which the patient was treated with dihydrotachysterol, J. A. M. A. 113: 749, 1939. CrossrefGoogle Scholar25. EatonCampLove LMJDJG: Symmetrical cerebral calcification, particularly of the basal ganglia, demonstrable roentgenographically: calcification of the finer cerebral blood vessels, Arch. Neurol. and Psychiat. 41: 921, 1939. CrossrefGoogle Scholar26. JordanKelsall AAR: Observations on a case of idiopathic hypoparathyroidism, Arch. Int. Med. 87: 242, 1951. CrossrefGoogle Scholar27. WhiteMudd PDSG: Observation on the effect of various factors on the duration of the electrical systole of the heart as indicated by the length of the Q-T interval of the electrocardiogram, J. Clin. Investigation 7: 387, 1929. CrossrefMedlineGoogle Scholar28. BarkerJohnstonWilson PSFDFN: The duration of systole in hypocalcemia, Am. Heart J. 14: 82, 1937. CrossrefGoogle Scholar29. SussmanEdinburgh RMA: Chronic idiopathic hypoparathyroidism simulating cardiac asthma, New England J. Med. 256: 734, 1957. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: *Received for publication July 11, 1957.From the Department of Neurology, Department of Medicine and Division of Endocrine and Cancer Research, Jefferson Medical College and Hospital.Requests for reprints should be addressed to Richard W. Naef, M.D., Department of Neurology, The Jefferson Medical College of Philadelphia, 1025 Walnut Street, Philadelphia 7, Pennsylvania. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byNeurological and psychiatric manifestations in idiopathic hypoparathyroidism: response to treatment.Dystonic Reactions to Prochlorperazine in HypoparathyroidismIdiopathic Hypoparathyroidism Associated with HyperthyroidismJAMES R. DAHL, M.D., SAMUEL D. MCFADDEN, M.D., EUGENE EISENBERG, M.D.ReferencesOCULAR MANIFESTATIONS OF IDIOPATHIC HYPOPARATHYROIDISM 1 February 1959Volume 50, Issue 2Page: 495-505KeywordsCalciumComaElectrocardiographyHospital medicineHypocalcemiaHypoparathyroidismNeurologyPhosphatases ePublished: 1 December 2008 Issue Published: 1 February 1959 PDF downloadLoading ...