THE TREATMENT OF ANGINA PECTORIS WITH PURE CRYSTALLINE KHELLIN
Authors: R C SCOTT, V J SEIWERT
Journal: Annals of Internal Medicine (1952)

Article1 May 1952THE TREATMENT OF ANGINA PECTORIS WITH PURE CRYSTALLINE KHELLINRALPH C. SCOTT, M.D., VINCENT J. SEIWERT, M.D.RALPH C. SCOTT, M.D.Search for more papers by this author, VINCENT J. SEIWERT, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-36-5-1190 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptINTRODUCTIONThe use of khellin in the treatment of angina pectoris has been the subject of numerous reports.1-8 The results have varied from those who reported 90 per cent improvement1 to those who found it to be no better than a placebo.4 Some possible causes for these discrepancies include spontaneous changes in the disease process, different methods of evaluating the results, and variations in the size of the dose of khellin used by the different workers.In a previous report,8we found only four of 20 patients studied who showed a definite reduction in the number of their anginal attacks...Bibliography1. AnrepKenawyBarsoum GVMRGS: The coronary vasodilatory action of khellin, Am. Heart J. 37: 531, 1949. CrossrefMedlineGoogle Scholar2. Ayad H: Khellin in angina pectoris, Lancet 1: 305, 1948. CrossrefGoogle Scholar3. RosenmanFishmanKaplanLevinKatz RHAPSRHGLN: Observations on the clinical use of visammin (khellin), J. A. M. A. 143: 160, 1950. CrossrefMedlineGoogle Scholar4. GreinerGoldCattellTravellBakstRinzlerBenzaminWarshawBobbKwitModellRothendlerMesseloffKramer THMJHSHZHLJALNTWHHCRML: A method for the evaluation of the effects of drugs on cardiac pain in patients with angina of effort: a study of khellin (visammin), Am. J. Med. 9: 143, 1950. CrossrefMedlineGoogle Scholar5. ArmbrustLevine CASA: The treatment of angina pectoris with a preparation of khellin (Ammi visnaga), Am. J. M. Sc. 220: 127, 1950. CrossrefMedlineGoogle Scholar6. OsherKatzWagner HLKHDJ: Khellin in the treatment of angina pectoris, New England J. Med. 244: 315, 1951. CrossrefMedlineGoogle Scholar7. DewarGrimson HATA: Further experience with khellin in angina of effort, Brit. Heart J. 13: 348, 1951. CrossrefMedlineGoogle Scholar8. ScottIglauerGreenKaufmanBermanMcGuire RCARSJWBJ: Studies on the effect of oral and parenteral administration of visammin (khellin) in patients with angina pectoris, Circulation 3: 80, 1951. CrossrefMedlineGoogle Scholar9. ScottSeiwertFowlerMcGuire RCVJNOJ: Studies on the use of dioxyline phosphate in the treatment of angina pectoris. Accepted for publication. Google Scholar10. Master AM: The two-step exercise electrocardiogram: a test for coronary insufficiency, Ann. Int. Med. 32: 842, 1950. LinkGoogle Scholar11. FreedbergRisemanSpiegl ASJEED: Objective evidence of efficacy of medicinal therapy in angina pectoris, Am. Heart J. 22: 494, 1941. CrossrefGoogle Scholar12. Riseman JE: The treatment of angina pectoris: a summary of 10 years' objective study, New England J. Med. 229: 670, 1943. CrossrefGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: *Received for publication November 24, 1951.From the Cardiac Laboratory, Cincinnati General Hospital, and the Department of Internal Medicine, College of Medicine, University of Cincinnati, Cincinnati, Ohio.This study was aided in part by a grant from Lloyd Brothers, Inc., Cincinnati, Ohio.†Khellin, 2 methyl 5, 8-dimethoxy-furano-chromome, is the presently accepted generic name of the Council on Pharmacy and Chemistry. This compound was previously designated as visammin.‡Trainee of the National Heart Institute.§Smith, Kline, and French Laboratories, Philadelphia, Pennsylvania.**The khellin used in the present study was supplied as Khelloyd, a pure crystalline form of khellin, by Lloyd Brothers, Inc., Cincinnati, Ohio, through the courtesy of Dr. L. J. Klotz. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byBibliographyDie Coronarerkrankungen. Coronarinsuffizienz, Angina pectoris und HerzinfarktDas PlaceboproblemMedikamente, die auf das kardiovaskuläre System wirkenMedikamente, die auf das kardiovaskuläre System wirkenDrug evaluation in angina pectoris: Khellin, heparin, PeritrateAMMI VISNAGASUPERIOR VENA CAVAL OCCLUSIONTreatment of Angina PectorisEffect of heparin in effort anginaTHE TREATMENT OF ANGINA PECTORIS WITH KHELLIN*PART IIJAMES J. CONN, M.D., R. W. KISSANE, M.D., F.A.C.P., RUTH A. KOON, M.D., F.A.C.P., THOMAS E. CLARK, M.D. 1 May 1952Volume 36, Issue 5Page: 1190-1197KeywordsAnginaHeartHospital medicineLongitudinal studiesResearch laboratories ePublished: 1 December 2008 Issue Published: 1 May 1952 PDF downloadLoading ...