Streptokinase Lysis of Intraventricular Thrombus and Pulmonary Emboli with Resolution of Acquired Intracardiac Shunt
Authors: Mohandas M. Shenoy, Sandor A. Friedman, Santi Dhar, Peter Berman
Journal: Annals of Internal Medicine (1985)

Brief Reports1 July 1985Streptokinase Lysis of Intraventricular Thrombus and Pulmonary Emboli with Resolution of Acquired Intracardiac ShuntMOHANDAS M. SHENOY, M.D., SANDOR A. FRIEDMAN, M.D., SANTI DHAR, M.D., PETER BERMAN, M.D.MOHANDAS M. SHENOY, M.D.Search for more papers by this author, SANDOR A. FRIEDMAN, M.D.Search for more papers by this author, SANTI DHAR, M.D.Search for more papers by this author, PETER BERMAN, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-103-1-65 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptStreptokinase has been used successfully for several thromboembolic disorders. In the case reported here, intravenous infusion of streptokinase eliminated right-to-left intracardiac shunting in a patient with acute pulmonary embolism. This treatment simultaneously lysed a left ventricular thrombus. The shunting site and thrombolysis were shown echocardiographically.A 94-year-old man was hospitalized with acute dyspnea and left arm paralysis. His history included a myocardial infarction but no neurologic disease. Physical findings included a temperature of 36.8 °C; pulse, 75 beats/min; blood pressure, 90/50 mm Hg; central cyanosis, tachypnea, and jugular venous distension. Heart sounds were normal and lungs were clear. His left...References1. KOVACSHILLABERGBLESOVSKYGERBODE GDTAF. Pathogenesis of arterial hypoxemia in pulmonary embolism. Arch Surg. 1966;93:813-23. CrossrefMedlineGoogle Scholar2. MORTHYLASASSOGIBBS SAP. Acquired right-to-left intracardiac shunts, and severe hypoxemia. Crit Care Med. 1978;6:28-31. CrossrefMedlineGoogle Scholar3. WEINREICHBURKEPAULETTO DJF. Left ventricular mural thrombi complicating acute myocardial infarction: long-term follow-up with serial echocardiography. Ann Intern Med. 1984;100:789-94. LinkGoogle Scholar4. SIMPSONOBERMANKOUCHOUKOSROGERS MANW. Prevalence of mural thrombi and systemic embolization with left ventricular aneurysm: effect of anticoagulation therapy. Chest. 1980;77:463-9. CrossrefMedlineGoogle Scholar5. REEDERLENGYELTAJIKSEWARDSMITHDANIELSON GMAJHG. Mural thrombus in left ventricular aneurysm: incidence, role of angiography, and relation between anticoagulation and embolization. Mayo Clin Proc. 1981;56:77-81. MedlineGoogle Scholar6. KEATINGGROSSSCHLAMOWITZ ESR. Mural thrombi in myocardial infarctions: prospective evaluation by two-dimensional echocardiography. Am J Med. 1983;74:989-95. CrossrefMedlineGoogle Scholar7. EIGLERMAURERSHAH NGP. Effect of early systemic thrombolytic therapy on left ventricular mural thrombus formation in acute anterior myocardial infarction. Am J Cardiol. 1984;54:261-3. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: MOHANDAS M. SHENOY, M.D.; SANDOR A. FRIEDMAN, M.D.; SANTI DHAR, M.D.; PETER BERMAN, M.D. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byPulmonary Physiology during Pulmonary EmbolismThrombolytic therapy for noncoronary diseasesNatural history of left ventricular thrombi: Their appearance and resolution in the posthospitalization period of acute myocardial infarctionThrombolytic Therapy: Current StatusLysis of Venous, Pulmonary, Prosthetic Valvular, Arterial, and Ventricular Clots 1 July 1985Volume 103, Issue 1Page: 65-66KeywordsDyspneaHeartHeart rateLungsMyocardial infarctionParalysisPulmonary embolismTachypneaTemperatureThrombosis ePublished: 1 December 2008 Issue Published: 1 July 1985 PDF downloadLoading ...