tbuckley/cabot-search huggingface dataset:
It’s Never Too Late
Authors: Colleen M Fitzgerald
Journal: JAMA (2011)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Abstract LB-399: Genome-wide expression analysis of subtypes of non-small cell lung carcinoma in highly degraded formalin-fixed paraffin-embedded tissue
Authors: Li Su, Zhaoxi Wang, Chen Wu, Lucian R. Chirieac, David C. Christiani
Journal: Cancer Research (2012)

Abstract Previous studies demonstrated that gene expression profiles from formalin-fixed paraffin-embedded (FFPE) tissues are largely comparable to fresh frozen matched tissue. This technology can assist in discovering biomarkers of lung cancer prognosis and progression by vastly increasing in the potential resources available for cancer research. In this study, we investigated the potential use of the Whole-Genome DASL HT Assay (Illumina, San Diego, CA) for global expression profiling in FFPE tissues obtained by surgical biopsy from patients with early stage non-small cell lung cancer (NSCLC). We obtained high-quality microarray data on 26 pairs of tumor/non-affected tissues, including 18 pairs of adenocarcinoma and 8 pairs of squamous carcinomas. Among genes differentially expressed between squamous carcinomas and adjacent non-affected lung tissue, we found that the AKR1C1 gene, encoding an aldo-keto reductases, was increased strongly in tumors (fold change: 3.0; p=0.02). This finding was consistent with previous reports that overexpression of AKR1C1 gene as an indicator of poor prognosis and chemoresistance in NSCLC. During pathway-based analysis using GeneGo database, we found that differentially expressed genes of adenocarcinoma were significantly enriched in the pathway of cytoskeleton remodeling_TGF, WNT and cytoskeletal remodeling; and differentially expressed genes of squamous carcinomas were significantly enriched in the pathway of Lung Neoplasms_Signal transduction. Our study demonstrates that with DASL expression profiling technology, genome-wide expression profiles can be successfully generated from FFPE lung tissues. Support: CA092824 and CA CA90578, and CA074386 from NCI Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 103rd Annual Meeting of the American Association for Cancer Research; 2012 Mar 31-Apr 4; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2012;72(8 Suppl):Abstract nr LB-399. doi:1538-7445.AM2012-LB-399
Charcot-Marie-Tooth Disease
Authors: Clyde W. Dawson, John B. Roberts
Journal: JAMA (1964)

Peroneal muscular atrophy (Charcot-Marie-Tooth disease) in nine children often demonstrated characteristic, if not diagnostic, clinical features. A positive family history was highly suggestive. Biopsy specimens from two patients were of no value. Electromyelographic studies were not characteristic, but motor nerve conduction velocity studies done on five patients were significant. Recent literature was correlated with the clinical pathological and electrodiagnostic studies done on these patients.
Lyme disease in the eighteenth century
Authors: N. Summerton
Journal: BMJ (1995)

Susan O'Connell indicated in her review that Lyme disease may have been present in Europe for over 100 years, although the term was not coined until the mid-1970s.1 In 1764 and 1771 the Reverend Dr John Walker visited the Hebrides to report on their economic potential. In the section on Jura he wrote, “Over the highlands in general there are fewer people to be observed either lame or decrepit than in any other country perhaps in Europe. But in the island of Jura, the cripples are remarkably numerous; owing to a very singular disease with which this island is peculiarly infected.

“This disease arises from a worm lodged under the skin, that penetrates with exquisite pain, the interior parts …
Present Status of Biplane Cineangiocardiography
Authors: Herbert L. Abrams
Journal: JAMA (1963)

Biplane cineangiocardiography has been performed with two 9-inch image intensifiers coupled at right angles to each other. The images on the output phosphors of the intensifiers are photographed by synchronized 35 mm motion picture cameras. Over 300 examinations have been undertaken in patients with clinical problems such as left-to-right shunts, right-to-left shunts, aortic valvular and subvalvular disease, mitral valvular disease, endocardial fibroelastosis, and many other congenital and acquired cardiac lesions. Biplane cine studies obviate the problem of chamber overlap, permit precise structure identification in two planes, and afford maximal information with a single dose of contrast agent. The method may now be considered a tested and feasible technique of exploring anatomic and physiologic changes in the cardiovascular system.
Perturbing the Organism: The Biology of Stressful Experience
Authors: Bruce S. McEwen
Journal: JAMA (1993)

"Stress" is a term everyone knows but no one can adequately define. "Stressful experience" is Herbert Weiner's very well-reasoned attempt to rename "stress" by emphasizing that it is an active process involving individual differences in the perception of, and behavioral and physiological response to, the challenges, in the Darwinian sense, of being alive. In this scholarly, readable, and generally very useful book, Weiner recounts the history of the concept of stress; defines what he means by "stressful experience"; and relates it to ill health and disease. He summarizes the experimental study of stressful experience through research on animals and describes in some detail advances in neuroscience and neuroendocrinology that have begun to elucidate some of the mediators of stressful experience in the brain and body, as well as the cellular mechanisms of their action. In a concluding chapter he summarizes new concepts derived from the study of mechanisms that illuminate
Experimental Curative Fluorescence-guided Surgery of Highly Invasive Glioblastoma Multiforme Selectively Labeled With a Killer-reporter Adenovirus
Authors: Shuya Yano, Shinji Miwa, Hiroyuki Kishimoto, Makoto Toneri, Yukihiko Hiroshima, Mako Yamamoto, Michael Bouvet, Yasuo Urata, Hiroshi Tazawa, Shunsuke Kagawa, Toshiyoshi Fujiwara, Robert M Hoffman
Journal: Molecular Therapy (2015)

Fluorescence-guided surgery (FGS) of cancer is an area of intense current interest. However, although benefits have been demonstrated with FGS, curative strategies need to be developed. Glioblastoma multiforme (GBM) is one of the most invasive of cancers and is not totally resectable using standard bright-light surgery (BLS) or current FGS strategies. We report here a curative strategy for FGS of GBM. In this study, telomerase-dependent adenovirus OBP-401 infection brightly and selectively labeled GBM with green fluorescent protein (GFP) for FGS in orthotopic nude mouse models. OBP-401-based FGS enabled curative resection of GBM without recurrence for at least 150 days, compared to less than 30 days with BLS.
Detection of serum hepatitis C virus RNA in HCV antibody-seropositive volunteer blood donors
Authors: Peter H. McGuinness, Alex G. Bishop, Alfred Lien, Brenton Wiley, Carolyn Parsons, Geoffrey W. McCaughan
Journal: Hepatology (1993)

Approximately 90% of subjects with chronic hepatitis resulting from hepatitis C virus infection have hepatitis C virus RNA in serum. However, the prevalence of hepatitis C virus RNA in serum from subjects with hepatitis C virus antibody associated with persistent normal liver biochemical values is unclear. Do these subjects have resolved or continuing infection with hepatitis C virus? The aim of this study was to examine whether subjects with hepatitis C virus antibody but normal ALT levels had evidence of ongoing infection. Our study population was divided into four groups. Groups 1, 2 and 3 comprised hepatitis C virus antibody-positive volunteer blood donors. Group 1 was made up of subjects found to be hepatitis C virus antibody-positive on enzyme-linked immunosorbent assay with persistent abnormal ALT levels (59 donors: 53 positive on recombinant immunoblot assay and 6 indeterminate). Group 2 members were hepatitis C virus antibody positive, with persistent normal ALT levels (50 donors: 39 positive on recombinant immunoblot assay and 11 indeterminate). Group 3 members were hepatitis C virus seropositive but negative on second-generation recombinant immunoblot assay (n = 48). Twenty patients (not blood donors) with chronic liver disease who were anti-hepatitis C virus seronegative were used as controls (group 4). Serum samples from all four groups were assayed for hepatitis C virus RNA on reverse transcription and a 40-cycle polymerase chain reaction with a combination of primers from the highly conserved 5'-noncoding and less-conserved third and fourth nonstructural regions. All assays were confirmed on hybridization with an internal probe.(ABSTRACT TRUNCATED AT 250 WORDS)
TECHNETIUM-99m LABELED MUROMONAB NR-LU-10(FAB) ANTIBODY IMAGING OF SMALL CELL AND NON-SMALL CELL BRONCHOGENIC CARCINOMAS
Authors: C VO, I SZAZ, P CHAMPION, D LISTER, T RIHELLA
Journal: Clinical Nuclear Medicine (1991)

S of the Society of Nuclear Medicine in Canada and Prairie Provinces Chapter, SNM Conjoint Meeting: PDF Only
Further recommendations for prescribing, reimbursement, technology development, and research in long-term oxygen therapy. Summary of the Fourth Oxygen Consensus Conference, Washington, D.C., October 15-16, 1993.
Authors: T L Petty, W J O'Donohue
Journal: American Journal of Respiratory and Critical Care Medicine (1994)

"Further recommendations for prescribing, reimbursement, technology development, and research in long-term oxygen therapy. Summary of the Fourth Oxygen Consensus Conference, Washington, D.C., October 15-16, 1993.." American journal of respiratory and critical care medicine, 150(3), pp. 875–877
House cats transmit human plague in US
Authors: F B Charatan
Journal: BMJ (1994)

House cats are a growing source of human plague in 13 southwestern states in the US, according to the federal Centers for Disease Control (CDC). There have been 362 cases of human plague reported since 1944, but at that time the disease was found in only three states - California, Arizona, and Mexico. Now cases have been reported from as far east as Texas and as far north as Montana.

Latest reports show 10 new cases last year. Seven of these were bubonic plague, two were due …
Copper, pH, and Hemodialysis
Authors: WILLIAM J. KLEIN
Journal: Annals of Internal Medicine (1971)

Letters and Comments1 January 1971Copper, pH, and HemodialysisWILLIAM J. KLEIN JR., M.D.WILLIAM J. KLEIN JR., M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-74-1-147_2 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: In the last paragraph of their recent article, "Copper-Induced Hemolytic Anemia," (Ann Intern Med73:409-412, 1970) Drs. Manzler and Schreiner state that markedly alkaline water in copper pipes could result from addition of copper to the water in those pipes. To the best of my knowledge even concentrated alkali is without effect on metallic copper, and cupric hydroxide, even if formed by an unusual mechanism, is insoluble.... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: WILLIAM J. KLEINJR., M.D.Affiliations: Department of Medicine Duke University Medical Center Durham, N. C. 27706 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byThe Controlled Use of Copper as an Antibacterial Agent in Respiratory Therapy Apparatus 1 January 1971Volume 74, Issue 1Page: 147-148KeywordsHemolytic anemia ePublished: 1 December 2008 Issue Published: 1 January 1971 PDF downloadLoading ...
Bacterial Phosphoproteomic Analysis Reveals the Correlation Between Protein Phosphorylation and Bacterial Pathogenicity
Authors: Ruiguang Ge, Weiran Shan
Journal: Genomics Proteomics & Bioinformatics (2011)

Abstract Increasing evidence shows that protein phosphorylation on serine, threonine and tyrosine residues is a major regulatory post-translational modification in the bacteria. This review focuses on the implications of bacterial phosphoproteome in bacterial pathogenicity and highlights recent development of methods in phosphoproteomics and the connectivity of the phosphorylation networks. Recent technical developments in the high accuracy mass spectrometry have dramatically transformed proteomics and made it possible the characterization of a few exhaustive site-specific bacterial phosphoproteomes. The high abundance of tyrosine phosphorylations in a few bacterial phosphoproteomes suggests their roles in the pathogenicity, especially in the case of pathogen–host interactions; the high abundance of multi-phosphorylation sites in bacterial phosphoprotein is a compensation of the relatively small phosphorylation size and an indicator of the delicate regulation of protein functions.
TCT-67 The First Establishment of Early Healing Profile, 9-month Neointimal Growth, and 24 Months Outcomes of the Dual Therapy Endothelial Progenitor Cell Capturing Sirolimus-eluting Stent as Assessed by Longitudinal Sequential Optical Coherence Tomography: The EGO-COMBO Study.
Authors: Stephen Wai Luen Lee, Simon C.C. Lam, Kelvin Ki Wan Chan, Shun Ling Kong, Chor Cheung Frankie Tam, Michael Ka Lam Wong, Anthony Yiu Tung Wong, Arthur See Yue Yung, Pak Hei Chan, P. Shea Catherine, Li-Wei Zhang, Raymond Hon Wah Chan, Michael Haude, Roxana Mehran, Akiko Maehara
Journal: Journal of the American College of Cardiology (2013)
Hydroxyurea-induced dermatomyositis-like eruption
Authors: P. SENET, S. ARACTINGI, M. PORNKUF, P. PERRIN, M. DUTERQUE
Journal: British Journal of Dermatology (1995)

Hydroxyurea is frequently used to treat myeloproliferative syndromes. Cutaneous lesions resembling those seen in dermatomyositis have rarely been reported in the course of treatment with hydroxyurea. We report six additional patients with this unusual adverse effect. All of the patients had a very typical and similar cutaneous eruption, with scaly, linear erythema on the dorsa of the hands. Leg ulceration occurred in two cases. Muscle involvement was never observed. One patient had unexplained lung disease. In all the others the disorder pursued a benign course, even when hydroxyurea was not withdrawn. Dermatomyositis-like lesions seem to be a not infrequent and characteristic adverse reaction to hydroxyurea. Investigations are not required, and the course is usually benign.
Cell‐specific location of Hfe: It is the 'cyte that matters
Authors: Darrell H. G. Crawford, Linda M. Fletcher, Gregory J. Anderson, Kris Kowdley, Geoffrey McCaughan, Christian Trautwein
Journal: Hepatology (2008)

Hereditary hemochromatosis (HH) is a prevalent, potentially fatal disorder of iron metabolism hallmarked by intestinal hyperabsorption of iron, hyperferremia, and hepatic iron overload. In both humans and mice, type 1 HH is associated with mutations in the broadly expressed HFE/Hfe gene. To identify where Hfe acts to prevent HH, we generated mice with tissue-specific Hfe ablations. This work demonstrates that local Hfe expression in hepatocytes serves to maintain physiological iron homeostasis, answering a long standing question in medicine and explaining earlier clinical observations.
TCT-110 First Experience With A Novel Anatomically Adapted Percutaneous Heart Valve For The Tricuspid Position
Authors: Desiree Pott, Margarita Malasa, Maximilian Kuetting, Ute Urban, Jan Roggenkamp, Ulrich Steinseifer, Nima Hatam, Rüdiger Autschbach, Jan Spillner, Andrea Amerini
Journal: Journal of the American College of Cardiology (2012)
Breaking Down the Barrier
Authors: Scott J. Harvey, Jeffrey H. Miner
Journal: Journal of the American Society of Nephrology (2007)

The glomerular capillary wall is thought to function as both a size- and charge-selective barrier. The concept of charge selectivity emerged from a series of now classic studies that used tracers such as dextran, peroxidase, and ferritin to evaluate the influence of molecular charge on glomerular
Joint public-private initiative aims to boost public health in India
Authors: Ganapati Mudur
Journal: BMJ (2006)

India will use a mixture of private donations and public funds to bolster education, training, and research in public health and stem what some doctors have called a steady deterioration of the national public health system.

The Public Health Foundation of India, launched in New Delhi last week, will build training capacity through five new public health schools, establish standards in public health education, and serve as a think tank for the government and the private sector.

The initiative has been welcomed by experts in public health and by health activists, who have long been concerned that medical care in …
p53-Induced Adipose Tissue Inflammation Is Critically Involved in the Development of Insulin Resistance in Heart Failure
Authors: Ippei Shimizu, Yohko Yoshida, Taro Katsuno, Kaoru Tateno, Sho Okada, Junji Moriya, Masataka Yokoyama, Aika Nojima, Takashi Ito, Rudolf Zechner, Issei Komuro, Yoshio Kobayashi, Tohru Minamino
Journal: Cell Metabolism (2012)
THE PRESENT STATUS OF THE PATHOLOGY OF MENTAL DISORDERS
Authors: ALBERT C. BUCKLEY
Journal: American Journal of Psychiatry (1921)

fact some workers were unwilling to accept Tuke's explanation for its presence, while Tuke considered it as due to "myelitic changes," that is, an increase of the white substance of Schwann.The most important advances began at the time when the attention of anatomists, physiologists and clinicians was directed to the subject of cerebral and spinal localization.Simultaneously in Great Britain
Reply to Giuseppe Procopio, Elena Verzoni and Filippo De Braud’s Letter to the Editor re: Camillo Porta, Emiliano Calvo, Miguel A. Climent, et al. Efficacy and Safety of Everolimus in Elderly Patients with Metastatic Renal Cell Carcinoma: An Exploratory Analysis of the Outcomes of Elderly Patients in the RECORD-1 Trial. Eur Urol 2012;61:826–33
Authors: Camillo Porta, Robert J. Motzer
Journal: European Urology (2012)
Medical Technology and Society: An Interdisciplinary Perspective
Authors: James M. Humber
Journal: JAMA (1991)

This book focuses on the economic and ethical issues associated with the development and use of medical technology. The text is intended for liberal arts undergraduates and all those interested in the problems posed by the use of modern medical technology. Because the text targets a general audience, it presupposes no specialized knowledge on the part of its readers. The book itself is divided into three parts. The first consists of three chapters and is intended to provide the reader with the basic tools necessary for analyzing the major technological, economic, and ethical issues associated with the evolution of America's health care provision system since the turn of the century. In chapter 1 the authors provide a synoptic overview of the development of medical practice and technology from earliest recorded history up until the present. Chapter 2 briefly explores the relationship between innovations in medical technology and changes in the
DO PATIENTS WITH CEREBRAL MALARIA HAVE CEREBRAL OEDEMA? A Computed Tomography Study
Authors: Sornchai Looareesuwan, NicholasJ. White, Pornthep Chanthavanich, BentE. Juel-Jensen, DavidA. Warrell, Pravan Sutharasamai, Kunthon Sundaravej, Danai Bunnag, Tranakchit Harinasuta
Journal: The Lancet (1983)
The Problem with Academic Medicine: Engineering Our Way into and out of the Mess
Authors: Jonathan Rees
Journal: PLoS Medicine (2005)

cademic medicine has tried to avoid the mess that has characterised much of clinical practice over the last quarter century. Instead its success has come from using techniques developed in biochemistry and molecular genetics, and applying them to disease. It has been a highly productive approach. For example, identiﬁ cation of the clinical syndrome AIDS, isolation of the causative agent, and development of diagnostic testing and effective therapy all happened in the space of a few years. Alongside such successes has come a redeﬁ nition of academic medicine. Medical research has become biomedical research; discovery ﬂ ows from bench to bedside and if it stutters, an injection of funds for more effective translation is required [2]. A plethora of organisms are sequenced, and all the genes in the mouse are to be “knocked out” [3]—all to serve the goal of improving human health, so we are told. Even the idea of clinical disciplines appears slightly passe, their traditional names a throwback to a less scientiﬁ c age—dermatology is now dermatological science, and neurology and psychiatry are now clinical neuroscience [4]. And if you are tempted at the end of the clinic—before you return to the sanctuary of the lab—to wonder about the mess of clinical medicine, to ask how it all ﬁ ts together, and to question the real outcomes of what you do, you run the risk of being put down. The put down goes like this: we do science; we do not question whether “Coke is better than Pepsi or approach A is better than approach B” [5]; we leave such choices to the consumer and the HMOs to decide upon. Back to the mice, and future tenure.