tbuckley/cabot-search huggingface dataset:
Abstract P4-05-02: Overexpression of the chemokine receptor CCR2 in the breast epithelium is associated with progression of DCIS
Authors: Benford Mafuvadze, Wei Bin Fang, Nikki Cheng
Journal: Cancer Research (2015)

Abstract Ductal carcinoma in situ (DCIS) is the most common type of non-invasive breast cancer diagnosed in women and an immediate precursor to invasive ductal carcinoma (IDC). It is largely unclear why some cases of DCIS progress to IDC, while others remain non-invasive. Current cyto- and histopathological approaches do not accurately predict disease progression, resulting in patients being under-treated or over-treated for DCIS. Our long-term goals are to identify key factors that lead to IDC that will enable the development of a molecular based approach to predict the risk of IDC, and a more tailored approach to treat DCIS. The CCL2/CCR2 chemokine pathway is best known for regulating macrophage recruitment to late stage breast tumors. In recent studies, we found that CCR2 and its binding ligand CCL2 were overexpressed in breast ductal carcinomas, correlating with tumor grade and poor patient prognosis. To further investigate the significance of CCR2 and CCL2, we performed flow cytometry analysis of breast epithelial cell lines, and found that increased CCR2 overexpression but not CCL2, was associated with invasive potential of the cell lines. CCL2 was found to be increased in stromal cells, particularly in cancer associated fibroblasts. Using a mammary intra-ductal injection model, we further examined for expression patterns of CCR2 and CCL2 in DCIS lesions derived from DCIS.com and Sum225 cells. Increased CCR2 was detected in DCIS.com lesions, which progressed to IDC within 10 weeks of injection, while CCR2 expression was found to be lowly expressed in non-invasive Sum225 lesions. CCL2 was detected in the stroma of both DCIS.com and Sum225 lesions. Overexpression of CCR2 in cultured non-invasive 67NR mammary carcinoma cells enhanced cell survival and increased wound closure. CCL2 treatment further enhanced cell survival and wound closure of CCR2 overexpressing 67NR cells. Knockdown of CCR2 in DCIS.com cells in 3D Matrigel: collagen cultures inhibited cellular invasion into the matrix. These studies indicate that CCR2 overexpression in ductal carcinoma cells, enhances intracellular signaling, and contributes to development of IDC. These data suggest that targeting the CCR2 pathway may be promising strategy for prevention or treatment of IDC. Citation Format: Benford Mafuvadze, Wei Bin Fang, Nikki Cheng. Overexpression of the chemokine receptor CCR2 in the breast epithelium is associated with progression of DCIS [abstract]. In: Proceedings of the Thirty-Seventh Annual CTRC-AACR San Antonio Breast Cancer Symposium: 2014 Dec 9-13; San Antonio, TX. Philadelphia (PA): AACR; Cancer Res 2015;75(9 Suppl):Abstract nr P4-05-02.
THE NATURE OF PELLAGRA: A CRITIQUE
Authors: James S. Mclester
Journal: Annals of Internal Medicine (1934)

Article1 October 1934THE NATURE OF PELLAGRA: A CRITIQUEJAMES S. MCLESTER, F.A.C.P.JAMES S. MCLESTER, F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-8-4-475 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptIn the first few years of the present century there suddenly appeared in the Alabama Insane Hospital a new disease of unknown nature, the salient characteristics of which were a violent dermatitis of the exposed parts, sore mouth, profuse diarrhea, grave nervous disturbances, and high mortality. The disorder was recognized finally by Searcy, a member of the resident staff, as identical with the pellagra described in the European literature. The rapid spread throughout the Southeastern states of this new and highly fatal disease excited general interest, and concerted efforts were made to determine its cause. Notable among these, but almost...Reference1. SILERGARRISONMCNEAL JFPEWJ: A statistical study of the relation of pellagra to use of certain foods and to location of domicile in six selected industrial communities, Arch. Int. Med., 1924, xiv, 293-373. CrossrefGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Birmingham, Alabama*Received for publication June 1, 1934. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byHautveränderungen bei Störungen des VitaminstoffwechselsNicotinsäuremangel und die PellagrafrageUeber Pellagra:I. Mitteilung 1 October 1934Volume 8, Issue 4Page: 475-482KeywordsDiarrheaDysenteryMortalityMouth ePublished: 1 December 2008 Issue Published: 1 October 1934 PDF downloadLoading ...
Tissue-based Genomics Augments Post-prostatectomy Risk Stratification in a Natural History Cohort of Intermediate- and High-Risk Men
Authors: Ashley E. Ross, Michael H. Johnson, Kasra Yousefi, Elai Davicioni, George J. Netto, Luigi Marchionni, Helen L. Fedor, Stephanie Glavaris, Voleak Choeurng, Christine Buerki, Nicholas Erho, Lucia L. Lam, Elizabeth B. Humphreys, Sheila Faraj, Stephania M. Bezerra, Misop Han, Alan W. Partin, Bruce J. Trock, Edward M. Schaeffer
Journal: European Urology (2015)
Definitions of Medical Injuries
Authors: Mark F Schiowitz
Journal: JAMA (2004)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Abstract P280: Home versus Hospital-Based Exercise Training and Associated Improvements in Functional Capacity and Quality of Life in Post-event Coronary Artery Disease Patients: An Indo-Iranian Multi-center Randomized Controlled Trial
Authors: Mohammad H Hadadzadeh, Arun G Maiya, Bijan Shad, Fardin Mirbolouk, R. PadmaKumar, Shirish S Borkar, Tom Devasia, Vivek G Raman, SreeKumar Nair, Vasudev Guddattu
Journal: Circulation (2015)

Introduction: Despite of decades of conception of Cardiac Rehabilitation (CR) programs, there is paucity on structure and effectiveness of Home-based exercise training (HmExTr) as a part of CR on functional capacity (FC) and quality of life (QOL) in post-event CAD patients. Hypothesis: Authors assessed the hypothesis that individualized HmExTr could be as effective as Hospital-based training (HsExTr) to improve FC and QOL in post-event CAD patients. Methods: Upon Ethical Committee approval from all centers, 660 post-event CAD patients (post-CABG, PTCA and post-MI on conservative treatment) were screened in a single blinded randomized controlled trial. Low and moderate risk patients (age of 35 to 75 years old) with written informed consent were included in the study. Recruited subjects (N=180) were randomly (concealed envelope method) allocated into three groups. HsExTr (n=60) underwent exercise training three times per week in hospital. HmExTr (n=60) underwent individualized HmExTr monitored every two wee...
Abstract 9483: High Mobility Group Box 1 Promotes Angiogenesis From Bone Marrow-Derived Endothelial Progenitor Cells After Myocardial Infarction
Authors: Yuichi Nakamura, Satoshi Suzuki, Takeshi Shimizu, Makiko Miyata, Tetsuro Shishido, Kazuhiko Ikeda, Shu-ichi Saitoh, Isao Kubota, Yasuchika Takeishi
Journal: Circulation (2014)

Background: High mobility group box 1 (HMGB1) is a DNA-binding protein secreted into extracellular space from necrotic cells and acts as a cytokine. We have reported that HMGB1 attenuates cardiac damage and restores cardiac function by enhancing angiogenesis after myocardial infarction (MI). We examined the role of HMGB1 in angiogenesis from bone marrow (BM) -derived cells in the heart, using transgenic mice with cardiac-specific overexpression of HMGB1 (HMGB1-TG). Methods and Results: HMGB1-TG mice and wild-type littermate (WT) mice were lethally irradiated and injected with BM cells from green fluorescent protein (GFP) mice through the tail vein. Two weeks after BM transplantation, the left anterior descending artery was ligated to create MI. In flow cytometry analysis, GFP-positive cells were identified as donor BM cells-derived endothelial progenitor cells (EPC) if they were positive for both CD34 and CD144 in granulocyte differentiation antigen-1-negative fraction. Circulating EPC mobilized from BM was increased at 1 week after MI in HMGB1-TG mice compared with WT mice (41.9% vs. 24.5%, P &lt; 0.01). Histological examination showed the size of MI was smaller in HMGB1-TG mice than in WT mice (42.9% vs. 59.1%, P &lt; 0.01) at 4 weeks after MI. In myocardial immunofluorescence staining, GFP and CD31 double-positive cells were BM-derived cells engrafted within myocardial tissue as vascular endothelial cells of new capillaries or arterioles. The ratio of these double positive cells to all cardiac cells was significantly higher in the HMGB1-TG mice than in the WT mice (8.3% vs. 2.9%, P &lt; 0.01). Enzyme-linked immunosorbent assay revealed that the levels of cardiac vascular endothelial growth factor at 1 week after MI were higher in HMGB1-TG mice than in WT mice (642.1 vs. 390.7 pg/dl, P &lt; 0.05). Conclusions: The present study demonstrated the direct in vivo evidence that HMGB1 promoted angiogenesis and reduced MI size by enhancing mobilization and differentiation of BM cells to EPC, migration to the border zone of MI, and engraftment as vascular endothelial cells of new capillaries or arterioles in the infarcted heart.
Abstract 13882: Impact of Ischemic Mitral Regurgitation on Long-Term Prognosis in Patients With Acute Myocardial Infarction After Primary Percutaneous Coronary Intervention
Authors: Kitae Kim, Shuichiro Kaji, Takeshi Kitai, Atsushi Kobori, Natsuhiko Ehara, Makoto Kinoshita, Tomoko Tani, Yutaka Furukawa
Journal: Circulation (2014)

Introduction: Ischemic mitral regurgitation (IMR) portends a poor prognosis during long-term follow-up and has been identified as an independent predictor of heart failure (HF) and reduced long-term survival. Despite the poor prognosis with chronic IMR, few studies report the impact of IMR on long-term prognosis in patients with acute myocardial infarction (AMI) who underwent primary percutaneous coronary intervention (PCI). Methods: We studied 674 consecutive patients with AMI from 2000 to 2006 who underwent emergent coronary angiography and primary PCI, and who were assessed by transthoracic echocardiography during index hospitalization. Primary outcomes were cardiac death and the development of HF during follow-up. Results: The mean age of the study patients was 65±12 years and 534 patients (79%) were men. Sixty patients (9%) had moderate or severe MR before hospital discharge. Patients with moderate or severe MR were older, more frequently non-smoker, and more likely to have Killip class ≥2, lower ejection fraction, larger left ventricular end-diastolic volume, compared with patients with no or mild MR. During the mean follow-up period of 5.7±3.6 years, 35 cardiac deaths and 53 episodes of HF occurred. Kaplan-Meier analysis revealed that patients with moderate or severe MR had significantly increased risk for cardiac death (P&lt;0.001), and HF (P&lt;0.001), compared with patients with no or mild MR. Multivariate analysis revealed that moderate or severe MR was the significant predictor of the development of cardiac death (P&lt;0.001), and the development of HF (P=0.006), independently of age, gender, history of MI, Killip class ≥2, initial TIMI flow≤1, peak CPK level, ejection fraction. Conclusions: Moderate or severe IMR detected early after AMI was independently associated with adverse cardiac events during long-term follow-up in patients with AMI after primary PCI.
Historical perspectives on theories of periodontal disease etiology
Authors: Philippe Hujoel, Lívia Guimarães Zina, Joana Cunha‐Cruz, Rodrigo Lopez
Journal: Periodontology 2000 (2011)

Abstract Our understanding of the causes of periodontal disease have two major competing paradigms: one that focuses on ‘local’ etiologic factors and one that focuses on remote ‘host‐level’ factors. We provide a historical overview of local and remote cause hypotheses and discuss some key reasons why the local cause hypothesis has become dominant.
Antibiotic Prescribing for Lower Respiratory Tract Infection—Reply
Authors: Paul Little
Journal: JAMA (2005)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Ein Vergleich der auslösenden Konfliktsituationen bei Asthma bronchiole und Lungentuberkulose
Authors: H.H. Studt
Journal: Psychotherapy and Psychosomatics (1971)

Having outlined the type of conflict situation which initiates symptoms in asthma and pulmonary tuberculosis, the author analyses the situation in respect of 86 cases of each of the two illnesses in terms of conflict type and sex of the patient. Men fall ill significantly more often as a result of conflicts in the area of 'occupation and profession', women in the area of 'love, sex and reproduction' (p < 0.001). Tuberculous patients, in turn, are significantly more often affected by certain 'love' conflicts than asthmatics (p < 0.001–0.009), and asthmatics by deaths (p < 0.005). In both cases, this is more pronounced in women. In the discussion, attention is drawn to the significance of these results for diagnosis and psychotherapy.
Quantitative proteomics for identification of membrane proteins as biomarkers for pancreatic cancer
Authors: Troels Z. Kristiansen, Mads Gronborg, H. C. Harsha, Michael G. Goggins, Anirban Maitra, Akhilesh Pandey
Journal: Cancer Research (2006)

Proc Amer Assoc Cancer Res, Volume 47, 2006

4456 

Pancreatic ductal adenocarcinoma is the fourth leading cause of cancer death in the United States. Detection of pancreatic cancer at an early stage offers the best hope for cure. However, currently available tumor markers for the detection of pancreatic cancer in clinical practice lack the sensitivity and specificity required for detection of potentially curable lesions. To discover novel pancreatic cancer biomarkers, we used a quantitative proteomic approach called Stable Isotope Labeling with Amino acids in Cell culture, or SILAC, to identify differentially expressed membrane proteins. Specifically, we examined the relative changes in membrane protein abundance between a non-neoplastic pancreatic ductal cell line (HPDE) and a pancreatic cancer-derived cell line (Panc-1). Our rationale was that the membrane proteins that are overexpressed in Panc-1 could serve as potential biomarkers and therapeutic targets. Overall, we were able to quantify changes in abundance of 220 proteins between these two cell lines. Some of the proteins identified in this screen as overexpressed in pancreatic-cancer-derived cells were already known to be involved in cancers. For example, one of the proteins identified in this study, EphA2, promotes tumorigenesis and is known to be overexpressed in several cancers. However, the large majority of the overexpressed proteins has not previously been implicated in pancreatic cancer and includes myeloid-associated differentiation marker, transmembrane protein 43 and a hypothetical transmembrane protein containing LRR domains. Thus, quantitative proteomics can be used as a screening tool for identification of differentially expressed proteins as potential biomarkers which can be further tested using other techniques such as immunohistochemistry for use in early detection of cancers.
Efficacy and safety of secukinumab in the treatment of moderate-to-severe plaque psoriasis: a randomized, double-blind, placebo-controlled phase II dose-ranging study
Authors: K.A. Papp, R.G. Langley, B. Sigurgeirsson, M. Abe, D.R. Baker, P. Konno, S. Haemmerle, H.J. Thurston, C. Papavassilis, H.B. Richards
Journal: British Journal of Dermatology (2012)

Summary Background Conventional systemic therapies for plaque psoriasis have not fully met the needs of patients, and although current biologic treatments are generally well tolerated, concerns exist with respect to long-term safety. Interleukin (IL)-17A is believed to be an important effector cytokine in the pathogenesis of psoriasis and is produced by Th17 cells, a class of helper T cells that act outside the established Th1/Th2 paradigm for regulation of innate and adaptive immunity. Objectives To assess the efficacy and safety of different doses of secukinumab, a fully human anti-IL-17A IgG1κ monoclonal antibody, in patients with moderate-to-severe plaque psoriasis. Methods Patients (n = 125) were randomized 1 : 1 : 1 : 1 : 1 to receive subcutaneous doses of placebo (n = 22) or secukinumab [1 × 25 mg (n = 29), 3 × 25 mg (n = 26), 3 × 75 mg (n = 21) or 3 × 150 mg (n = 27)] at weeks 0, 4 and 8. After the 12-week treatment period, patients entered a follow-up period of 24 weeks. The primary efficacy outcome was at least 75% improvement from baseline in the Psoriasis Area and Severity Index score (PASI 75); secondary outcomes included the Investigator’s Global Assessment (IGA) and PASI 90 and 50 response rates. Results After 12 weeks of treatment, secukinumab 3 × 150 mg and 3 × 75 mg resulted in significantly higher PASI 75 response rates vs. placebo (82% and 57% vs. 9%; P &amp;lt; 0·001 and P = 0·002, respectively). Higher PASI 75 response rates compared with placebo were maintained throughout the follow-up period with these dosages [week 36, 26% (n = 7) and 19% (n = 4) vs. 4% (n = 1), respectively], with a gradual decline of PASI 75 response over time after the dosing period. IGA response rates were significantly higher in the 3 × 150 mg group vs. placebo at week 12 (48% vs. 9%; P = 0·005) and were consistently higher for the 3 × 150 mg and 3 × 75 mg groups vs. placebo at all time points from week 4 onward. The PASI 90 response rate was significantly higher in the 3 × 150 mg group vs. placebo (52% vs. 5%) at week 12 and remained higher during the follow-up period. Secukinumab was well tolerated. Two cases of neutropenia (≤ grade 2) were reported in the 3 × 150 mg cohort. Conclusions Treatment with subcutaneous secukinumab 3 × 75 mg and 3 × 150 mg met the primary outcome of PASI 75 response achievement after 12 weeks, demonstrating efficacy in moderate-to-severe psoriasis.
930. Muscle Stem Cells Deliver Dystrophin and Adopt a Cardiac Phenotype through Both Differentiation and Fusion in the Dystrophic (mdx) Heart
Authors: Thomas R. Payne, Hideki Oshima, Tetsuro Sakai, Yiqun Ling, Burhan Gharabeih, James H. Cummins, Johnny Huard
Journal: Molecular Therapy (2004)

A reduction or absence of dystrophin protein in the heart will cause cardiac muscle degeneration and the progressive development of cardiomyopathy. In this study, we investigated the ability of a population of murine skeletal muscle–derived stem cells (MDSCs) to deliver dystrophin and acquire a cardiac phenotype after transplantation into the dystrophic (mdx) murine heart. The injected MDSCs engrafted and partially restored dystrophin expression within the dystrophic (mdx) myocardium for up to 12 weeks after implantation. In these hearts, approximately 3-5% of the donor-labeled cells expressed a cardiac phenotype, and more than half of these cells displayed a hybrid cardiac and skeletal muscle phenotype at 2, 4, 8 and 12 weeks after implantation. The majority of the donor cells expressing a cardiac phenotype were located along the periphery of the graft or within the host myocardium. Transplantation of female MDSCs into male recipient hearts revealed that the injected cells acquired a cardiac phenotype through both differentiation and fusion with host cardiomyocytes. The formation of fibrotic tissue within the injection site may have inhibited further acquisition of a cardiac phenotype by the implanted MDSCs. The results presented here support the potential use of MDSCs to advance muscle cell–based therapies for cardiac repair.
Use of Biomonitoring Data to Evaluate Methyl Eugenol Exposure
Authors: Steven H. Robison, Dana B. Barr
Journal: Environmental Health Perspectives (2006)

Methyl eugenol is a naturally occurring material found in a variety of food sources, including spices, oils, and nutritionally important foods such as bananas and oranges. Given its natural occurrence, a broad cross-section of the population is likely exposed. The availability of biomonitoring and toxicology data offers an opportunity to examine how biomonitoring data can be integrated into risk assessment. Methyl eugenol has been used as a biomarker of exposure. An analytical method to detect methyl eugenol in human blood samples is well characterized but not readily available. Human studies indicate that methyl eugenol is short-lived in the body, and despite the high potential for exposure through the diet and environment, human blood levels are relatively low. The toxicology studies in animals demonstrate that relatively high-bolus doses administered orally result in hepatic neoplasms. However, an understanding is lacking regarding how this effect relates to the exposures that result when food containing methyl eugenol is consumed. Overall, the level of methyl eugenol detected in biomonitoring studies indicates that human exposure is several orders of magnitude lower than the lowest dose used in the bioassay. Furthermore, there are no known health effects in humans that result from typical dietary exposure to methyl eugenol.