Oral Antimicrobial Therapy for Osteomyelitis
Authors: Layne O. Gentry
Journal: Annals of Internal Medicine (1991)

Editorials1 June 1991Oral Antimicrobial Therapy for OsteomyelitisLayne O. Gentry, MDLayne O. Gentry, MDAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-114-11-986 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptDuring the past several years, antimicrobial agents have been developed that can be administered orally, are active against the spectrum of organisms that cause osteomyelitis, and are relatively nontoxic when administered over a prolonged period. The most important among these agents are the oral fluoroquinolones, which include ciprofloxacin and ofloxacin in the United States and Pefloxacin in Europe. These agents penetrate bone at sufficient concentrations to inhibit most strains of Staphylococcus aureus, Enterobacteriaceae, and Pseudomonas aeruginosa (1).Chronic, or recurrent, osteomyelitis has been principally caused by staphylococci. Carefully conducted trials in 1968 and 1976 have shown that high-dose oral penicillin...References1. Neu H. Use of fluoroquinolone antimicrobial agents by cardiovascular and cardiopulmonary surgeons. Tex Heart Inst J. 1990; 17:12-21. MedlineGoogle Scholar2. Bell S. Further observations on the value of oral penicillins in chronic staphylococcal osteomyelitis. Med J Aust. 1976;2:591-3. CrossrefMedlineGoogle Scholar3. Gentry L. Antimicrobial therapy for osteomyelitis. Inf Dis Clin North Am. 1990;4:485-99. CrossrefMedlineGoogle Scholar4. Gentry L. Antibiotic therapy for osteomyelitis. Orthop Clin North Am. 1991;[In press]. MedlineGoogle Scholar5. GentryRodriguez-Gomez LG. Oral ciprofloxacin compared with parenteral antibiotics in the treatment of osteomyelitis. Antimicrob Agents Chemother. 1990;34:40-3. CrossrefMedlineGoogle Scholar6. PetersonLissackCanter LLK. Therapy of lower extremity infections with ciprofloxacin in patients with diabetes mellitus, peripheral vascular disease, or both. Am J Med. 1989;86:801-7. CrossrefMedlineGoogle Scholar7. GentryRodriguez-Gomez LG. Ofloxacin versus parenteral therapy for chronic osteomyelitis. Antimicrob Agents Chemother. 1991;35:[In press]. Google Scholar8. TruckisHooperWolfson MDJ. Emerging resistance to fluoroquinolones in staphylococci: an alert [Editorial]. Ann Intern Med. 1991;114:424-6. LinkGoogle Scholar9. Gentry L. Outpatient management of osteomyelitis in a DRG era. In: Pankey GA. Outpatient Antimicrobial Therapy. Oxford Health Care Inc; 1989:81-8. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: St. Luke's Episcopal Hospital Houston, TX 77030 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byQuinolonesTreatment of Osteomyelitis and Septic ArthritisReview of the Quinolone FamilyQuinolonesCombination of Quinupristin-Dalfopristin (Synercid) and Rifampin Is Highly Synergistic in Experimental Staphylococcus aureus Joint Prosthesis InfectionRandomized Prospective Controlled Trial of Recombinant Granulocyte Colony-Stimulating Factor as Adjunctive Therapy for Limb-Threatening Diabetic Foot InfectionFLUOROQUINOLONESThe QuinolonesREACTIVATION OF OSTEOMYELITIS CAUSED BY STAPHYLOCOCCUS AUREUS AFTER 50 YEARSAntimicrobial AgentsOUTPATIENT PARENTERAL ANTIMICROBIAL THERAPY FOR OSTEOMYELITISEfficacy of Teicoplanin and Autoradiographic Diffusion Pattern of [ 14 C]Teicoplanin in Experimental Staphylococcus aureus Infection of Joint ProsthesesToe amputation in the diabetic patientManagement of osteomyelitisOsteomyelitisThérapeutique des infections à Staphylococcus aureus sensible à la méticilline (SAMS)Bacterial osteomyelitis in adults: Evolving considerations in diagnosis and treatmentEfficacy of sparfloxacin and autoradiographic diffusion pattern of [14C]Sparfloxacin in experimental Staphylococcus aureus joint prosthesis infectionOfloxacin: Why the Increased Popularity?The role of new antibiotics for the treatment of infections in the emergency departmentOpportunities for i.v. to oral switch in the management of infections: the role of quinolonesOsteomyelitisEfficacy of Oral Fleroxacin in Bone and Joint InfectionsOral Quinolone Treatment for OsteomyelitisHenry M. Blumberg, MD 1 June 1991Volume 114, Issue 11Page: 986-987KeywordsAntimicrobialsAttentionBoneEnterobacteriaceaeInfectious diseasesOsteomyelitisPenicillinPseudomonas aeruginosaStaphylococcus aureus Issue Published: 1 June 1991 PDF downloadLoading ...