tbuckley/cabot-search huggingface dataset:
Skin‐prick‐test‐induced anaphylaxis
Authors: E. Novembre, R. Bernardini, G. Bertini, G. Massai, A. Vierucci
Journal: Allergy (1995)

An anaphylactic reaction occurred in a 57‐year‐old man after a prick by prick test with fresh kiwi and in a 29‐year‐old man after prick tests with some species offish. Both patients had a history of anaphylaxis after ingestion of kiwi and fish, respectively. These cases suggest that, especially in patients with a history of anaphylaxis, all efforts should be made to minimize the risk of systemic reactions, and skin prick testing should be performed only in places equipped to treat anaphylaxis.
TCT-683 The Impact of Side Branch Predilatation on Procedural and Long-term Clinical Outcomes in Coronary Bifurcation Lesions Treated by Provisional Approach: Results from the COBIS (Coronary BIfurcation Stent) Registry
Authors: Pil Sang Song, Young Bin Song, Tae Jin Kim, Jae Kyun Kim, Dong-Kie Kim, Sang-Hoon Seol, Doo-Il Kim, Jeong Hoon Yang, Joo-Yong Hahn, Seung-Hyuk Choi, Jin-Ho Choi, Hyeon-Cheol Gwon
Journal: Journal of the American College of Cardiology (2012)
Quackery in West Virginia.
Authors: M. P. Goff
Journal: JAMA (1900)

Clarksburg, W. Va., Jan. 5, 1900. <h3>To the Editor:</h3> The physicians of this state are making a determined fight against all forms of quackery. We are not making any criticisms in regard to any system of medicine, but are desirous of requiring all who practice medicine to conform to the laws of our state. For the past two years we have had a great deal of trouble with osteopaths and "Christian Science" practitioners, inasmuch as they refuse to take the examination, claiming that they are not practicing medicine. The statute of our state is very plain, and we now have an indictment against these people which we are desirous of pushing to the bitter end. Will you or your readers send me any court decisions bearing directly or indirectly on matters of this and similar character? Should any be sent by express, please send via the United States Express Co.,
Dipyridamole-induced ST segment depression in hypertrophic cardiomyopathy is associated with a reduced coronary flow response
Authors: Paolo Camici, Giampaolo Chiriatti, Roberto Lorenzoni, Roberto Gistri, Piero Salvadori, Lucio Fusani, Lauro Papi, Eugenio Picano, Antonio L'Abbate
Journal: Journal of the American College of Cardiology (1991)
ENDOVASCULAR RECANALIZATION OF CENTRAL VEIN ACCESS TO ALLOW PACEMAKER/CARDIOVERTER-DEFIBRILLATOR IMPLANTATION
Authors: Gabriel Maluenda, Francis Bustos, Federico Viganego, Sameer Jamel, Paul Fiorilli, Nicholas Hanna, Itsik Ben-Dor, Michael Mahmoudi, Michael A. Gaglia, Kohei Wakabayashi, Rafael Romaguera, Rebecca Torguson, Susan O'Donoghue, William O. Suddath, Augusto D. Pichard, Lowell F. Satler, Ron Waksman, Nelson L. Bernardo
Journal: Journal of the American College of Cardiology (2011)
The Involvement of RNA in Protein Synthesis
Authors: Jonathan R. Warner, Ruy Soeiro
Journal: New England Journal of Medicine (1967)

Translation of mRNADirection of TranslationMessenger RNA possesses a chemical polarity in its structure. The phosphodiester linkage runs from 5' to 3' on the ribose moiety of adjacent nucleotides. When the message is translated into protein, in which direction is it read? Direct in vitro experiments bearing on this subject suggest that the reading is from the 5' to the 3′ end.It is known55 that in the synthesis of a protein, the NH2 terminal end is synthesized first. Accordingly, if a polynucleotide messenger of known base composition is used to direct in vitro protein synthesis, the NH . . .
SITOPHOBIA OF ENTERIC ORIGIN.
Authors: MAX EINHORN
Journal: JAMA (1901)

Sitophobia, meaning fear of food, is a condition which may last a long period of time and, if not successfully treated, may endanger life. It is therefore natural that this subject should command the full attention of the practitioner. When I first used the term sitophobia I was not aware that Guislain<sup>1</sup>had already employed the same word to designate the refusal of food which is so often encountered in cases of melancholia and in the insane. For this condition, however, the word introduced by Sollier<sup>2</sup>, namely, "sitieirgy," meaning refusing food, seems to be more appropriate. For, in the insane, the patients do not want to eat, not because they are afraid of the food, but for different reasons; either they are in a state of depression, unwilling to do anything, even eating, or they have suicidal ideas, or they have illusions that the food may be poisoned,
Induction of circulating myelin basic protein and proteolipid protein-specific transforming growth factor-beta1-secreting Th3 T cells by oral administration of myelin in multiple sclerosis patients.
Authors: H Fukaura, S C Kent, M J Pietrusewicz, S J Khoury, H L Weiner, D A Hafler
Journal: Journal of Clinical Investigation (1996)

Oral administration of antigen is a long recognized method of inducing systemic immune tolerance. In animals with experimental autoimmune disease, a major mechanism of oral tolerance triggered by oral administration of antigen involves the induction of regulatory T cells that mediate active suppression by secreting the cytokine TGF-beta 1. Multiple sclerosis (MS) is a presumed T cell-mediated Th1 type autoimmune disease. Here, we investigated whether in MS patients oral myelin treatment, containing both myelin basic protein (MBP) and proteolipid protein (PLP), induced antigen specific MBP or PLP reactive T cells that either secreted IL4, TGF-beta1, or alternatively did Th1 type sensitization occur as measured by IFN-gamma secretion. Specifically, 4,860 short-term T cell lines were generated to either MBP, PLP, or tetanus toxoid (TT) from 34 relapsing-remitting MS patients: 17 orally treated with bovine myelin daily for a minimum of 2 yr as compared to 17 nontreated patients. We found a marked increase in the relative frequencies of both MBP and PLP specific TGF-beta1-secreting T cell lines in the myelin treated MS patients as compared to non-treated MS patients (MBP P < 0.001, PLP P < 0.003). In contrast, no change in the frequency of MBP or PLP specific IFN-gamma or TT specific TGF-beta1 secreting T cells were observed. These results suggest that the oral administration of antigens generates antigen specific TGF-beta1 secreting Th3 cells of presumed mucosal origin that represent a distinct lineage of T cells. Since antigen-specific TGF-beta1 secreting cells localize to the target organ and then suppress inflammation in the local microenvironment, oral tolerization with self antigens may provide a therapeutic approach for the treatment of cell-mediated autoimmune disease which does not depend upon knowledge of the antigen specificity of the original T cell clone triggering the autoimmune cascade.
Regulation of glycogen phosphorylase activity in isolated human hepatocytes
Authors: Stefaan Keppens, Ann Vandekerckhove, Han Moshage, Sing Hiem Yap, Raymond Aerts, Henri de Wulf
Journal: Hepatology (1993)

Hepatocytes were isolated from human liver tissue by a two-step perfusion technique. They were treated with vasopressin, angiotensin, ATP and phenylephrine, which are known to be Ca 2+ -mediated glycogenolytic agents in rat liver tissue, and as a control, they were treated with the cyclic AMP-mediated hormones glucagon and isoproterenol. All agonists induce a timedependent activation of glycogen phosphorytase. Glucagon and isoproterenol induce a somewhat higher degree of phosphorylase activation compared with vasopressin, angiotensin, ATP and phenylephrine, which all increase inositol tris-phosphate levels and have no effect on the cyclic AMP levels. The total activity of glycogen phosphorylase ( a + b ), amounting to 30 to 35 mU/mg protein, is found to be much lower than that found in rat liver tissue. Because only minor differences could be found, we conclude that the regulation of glycogen phosphorylase in human liver tissue is basically the same as that found in rat liver tissue. (Hepatology 1993;17:610-614.)
Validation of real-time three-dimensional echocardiography for quantifying left ventricular volumes in the presence of a left ventricular aneurysm: in vitro and in vivo studies
Authors: Jian Xin Qin, Michael Jones, Takahiro Shiota, Neil L Greenberg, Hiroyuki Tsujino, Michael S Firstenberg, Pankaj C Gupta, Arthur D Zetts, Yong Xu, Jing Ping Sun, Lisa A Cardon, Jill A Odabashian, Scott D Flamm, Richard D White, Julio A Panza, James D Thomas
Journal: Journal of the American College of Cardiology (2000)
Adhesion of Activated Platelets to Endothelial Cells: Evidence for a GPIIbIIIa-dependent Bridging Mechanism and Novel Roles for Endothelial Intercellular Adhesion Molecule 1 (ICAM-1), αvβ3 Integrin, and GPIbα
Authors: Thomas Bombeli, Barbara R. Schwartz, John M. Harlan
Journal: The Journal of Experimental Medicine (1998)

Although it has been reported that activated platelets can adhere to intact endothelium, the receptors involved have not been fully characterized. Also, it is not clear whether activated platelets bind primarily to matrix proteins at sites of endothelial cell denudation or directly to endothelial cells. Thus, this study was designed to further clarify the mechanisms of activated platelet adhesion to endothelium. Unstimulated human umbilical vein endothelial cell (HUVEC) monolayers were incubated with washed, stained, and thrombin-activated human platelets. To exclude matrix involvement, HUVEC were harvested mechanically and platelet binding was measured by flow cytometry. Before the adhesion assay, platelets or HUVEC were treated with different receptor antagonists. Whereas blockade of platelet β1 integrins, GPIbα, GPIV, P-selectin, and platelet-endothelial cell adhesion molecule (PECAM)-1 did not reduce platelet adhesion to HUVEC, blockade of platelet GPIIbIIIa by antibodies or Arg-Gly-Asp (RGD) peptides markedly decreased adhesion. Moreover, when platelets were treated with blocking antibodies to GPIIbIIIa-binding adhesive proteins, including fibrinogen and fibronectin, and von Willebrand factor (vWF), platelet binding was also reduced markedly. Addition of fibrinogen, fibronectin, or vWF further increased platelet adhesion, indicating that both endogenous platelet-exposed and exogenous adhesive proteins can participate in the binding process. Evaluation of the HUVEC receptors revealed predominant involvement of intercellular adhesion molecule (ICAM)-1 and αvβ3 integrin. Blockade of these two receptors by antibodies decreased platelet binding significantly. Also, there was evidence that a component of platelet adhesion was mediated by endothelial GPIbα. Blockade of β1 integrins, E-selectin, P-selectin, PECAM-1, vascular cell adhesion molecule (VCAM)-1 and different matrix proteins on HUVEC did not affect platelet adhesion. In conclusion, we show that activated platelet binding to HUVEC monolayers is mediated by a GPIIbIIIa-dependent bridging mechanism involving platelet-bound adhesive proteins and the endothelial cell receptors ICAM-1, αvβ3 integrin, and, to a lesser extent, GPIbα.
Cimetidine Postmarket Outpatient Surveillance Program-Reply
Authors: Lawrence M. Gifford
Journal: JAMA (1981)

In Reply.—  We thank Mr Crawley and Drs Gardner and Lee for their comments on our article and appreciate the opportunity to respond.  We believe an unfortunate and ambiguous choice of working on our part is responsible for their concern over the statement  that occurred after stopping treatment were clearly unrelated to cimetidine. We did not mean to imply that because a death occurred after treatment with cimetidine (Tagamet), the drug could be exonerated from a relationship. As pointed out by Crawley and associates this would have negated an important aspect of the program. Actually, all deaths were carefully reviewed independently by two physicians, and it was only after this assessment that we were able to make the aforementioned statement. We apologize for the ambiguity.  We tabulated patients rather than events in figuring the incidence of adverse reactions, because there was usually a striking overlap between two events when
Funds Sought to Save Clinical Research from Endangered List
Authors: Cori Vanchieri
Journal: Annals of Internal Medicine (1997)

Currents15 September 1997Funds Sought to Save Clinical Research from Endangered ListCori VanchieriCori VanchieriSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-127-6-199709150-00031 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail With new data supporting the concern that competition in the health care marketplace and pressures to reduce costs are hampering clinical research, academic researchers, managed care leaders, pharmaceutical representatives, and patient advocates gathered at the Institute of Medicine in Washington, D.C., to debate the issues troubling clinical research and to discuss a new proposal to bring substantial funds to this enterprise.Although some participants blamed managed care for squeezing research budgets, others, like Herbert Pardes, MD, of Columbia University College of Physicians and Surgeons in New York, disagreed. “Managed care organizations aren't the problem. They are the messengers from society ... Author, Article, and Disclosure InformationAffiliations: PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 15 September 1997Volume 127, Issue 6Page: 500KeywordsHealth care sectorHealth insuranceMedicarePatient advocacyPatientsPeer reviewResearch laboratoriesRiversSurgeonsTaxes Issue Published: 15 September 1997 CopyrightCopyright © 1997 by American College of Physicians. All Rights Reserved.PDF DownloadLoading ...
SIZE OF THE NORMAL HEART
Authors: A. E. FOSSIER
Journal: JAMA (1924)

The determination of the size of the normal heart is of the greatest importance to cardiologists. The normal size of this organ is so variable and depends so greatly on the sex, age, height and weight of the individual, that it is necessary that a basis of its normality be established, as the slightest modification of its size may reveal an underlying pathologic condition, for what may be the size of a normal heart in some individuals may in others determine a disease condition. The radiologists have tried to establish a basis of cardiac normality, but because of so many unavoidable sources of error they have been to a large extent unsuccessful. The most patent errors in the delimitation of the heart area by means of the roentgen ray are: size and contour of the chest, position of the heart, exact centralization of the rays, accurate focusing, deformities of the
Cooperative Roles of CTLA-4 and Regulatory T Cells in Tolerance to an Islet Cell Antigen
Authors: Mark P. Eggena, Lucy S.K. Walker, Vijaya Nagabhushanam, Luke Barron, Anna Chodos, Abul K. Abbas
Journal: The Journal of Experimental Medicine (2004)

Adoptive transfer of ovalbumin (OVA)-specific T cells from the DO.11 TCR transgenic mouse on a Rag−/− background into mice expressing OVA in pancreatic islet cells induces acute insulitis and diabetes only if endogenous lymphocytes, including regulatory T cells, are removed. When wild-type OVA-specific/Rag−/− T cells, which are all CD25−, are transferred into islet antigen–expressing mice, peripheral immunization with OVA in adjuvant is needed to induce diabetes. In contrast, naive CTLA-4−/−/Rag−/− OVA-specific T cells (also CD25−) develop into Th1 effectors and induce disease upon recognition of the self-antigen alone. These results suggest that CTLA-4 functions to increase the activation threshold of autoreactive T cells, because in its absence self-antigen is sufficient to trigger autoimmunity without peripheral immunization. Further, CTLA-4 and regulatory T cells act cooperatively to maintain tolerance, indicating that the function of CTLA-4 is independent of regulatory cells, and deficiency of both is required to induce pathologic immune responses against the islet self-antigen.
Polymorphism in the 5′ Flanking Region of the Human Insulin Gene: A Genetic Marker for Non-Insulin-Dependent Diabetes
Authors: Peter S. Rotwein, John Chirgwin, Michael Province, William C. Knowler, David J. Pettitt, Barbara Cordell, Howard M. Goodman, M. Alan Permutt
Journal: New England Journal of Medicine (1983)

We sought to determine whether differences in the human insulin gene or its immediate flanking sequences could be found in diabetes. Peripheral leukocyte DNA from 217 unrelated persons, including blacks, whites, and Pima Indians, was analyzed by restriction-enzyme digestion, blotting to nitrocellulose filters, and hybridization to cloned [32P]insulin-gene probes. A region of length variation including deletions (0.1 to 0.2 kilobase pairs) or insertions (0.6 to 5.5 kb) of DNA was found only in the immediate 5' flanking region in 33 per cent of the genes examined. A 1.6-kb insertion accounted for 80 per cent of the polymorphism. This variant was found more often in subjects with non-insulin-dependent diabetes than in nondiabetics, regardless of race (P = 0.011). Length polymorphism in the 5' flanking region of the insulin gene may provide a genetic marker for non-insulin-dependent diabetes.
Clinical Crossroads: A 36-Year-Old Woman Recuperating From Stroke-Reply
Authors: Michael P. Alexander
Journal: JAMA (1997)

In Reply.  —Dr Palma's analysis of the acute phase of the illness of Mrs X is plausible. However, the clinical course of hemorrhagic transformation is common even in patients with ischemic infarction who do not receive rt-PA. There are 2 types of hemorrhage in ischemic brain, intraparenchymal hemorrhage and hemorrhagic transformation. There is recent evidence that rt-PA may not increase the risk of hemorrhagic transformation. 1 Mrs X had hemorrhagic transformation, but it is not certain that rt-PA was responsible, nor that the patchy hemorrhage worsened the outcome of the infarction.  Standard stroke scale assessments may have been applied in her case at the initial treating hospital. Information from that phase of her illness was not available to me. Standard assessment is essential in all patients with stroke, and particularly in those receiving rt-PA, thus, my emphasis on adherence to published guidelines that include such a requirement. 2   The emerging science of
Diffuse Interstitial Fibrosis: An Appraisal of Therapy.
Authors: Asher Marks
Journal: Annals of Internal Medicine (1965)

s1 November 1965Diffuse Interstitial Fibrosis: An Appraisal of Therapy.Asher Marks, M.D. (Associate)Asher Marks, M.D. (Associate)Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-63-5-918_3 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptFifteen years ago Austrian described a group of diseases comprising an "alveolar-capillary block" syndrome. Criteria for inclusion were: diffuse, finely dispersed radiographic lesions, essentially normal dynamic ventilatory function, and measured impairment of alveolar-capillary gas exchange. Although the concept of pure diffusion abnormalities has been recently challenged, increasing numbers of patients and diseases are described in which diffuse pulmonary interstitial abnormalities are associated with the enumerated abnormalities. At present well over 100 different disease entities have been described. A large segment of these patients is comprised of individuals with diffuse interstitial fibrosis of unknown etiology. Although the similar histologic appearance does... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Miami, Florida PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 November 1965Volume 63, Issue 5Page: 918-919KeywordsEtiologyFibrosisLesionsPulmonary diseases Issue Published: 1 November 1965 PDF downloadLoading ...
Effect of electrohydraulic and extracorporeal shock waves on gastrointestinal cancer cells and their response to cytotoxic agents.
Authors: A Warlters, D L Morris, A Cameron-Strange, W Lynch
Journal: Gut (1992)

Electrohydraulic and extracorporeal shock waves were used to treat the colorectal and gastric cancer cell lines LIM 2412 and MKN45. The effect on viability, cell proliferation, and the action of antitumour drugs was studied. Results showed that electrohydraulic and extracorporeal shock waves were cytotoxic to all cell lines and also caused considerable inhibition of cell proliferation. A significant additional reduction in cell viability was achieved by shock waves in cancer cells treated with methotrexate, 5-fluorouracil, and vincristine. These data indicate that shock waves may be worthy of further evaluation in the treatment of gastrointestinal cancers.
Letter from...Chicago. Buttering opsonins.
Authors: G Dunea
Journal: BMJ (1977)

FIG 13 Fibroma of plantar fascia.excision carries a high recurrence rate, and the histology is difficult to interpret as the nodules are cellular and may be reported as fibrosar- comata when needless amputation and irradiation may ensue. ConclusionLess than a century ago the type of surgery described above was considered beneath the dignity of the professional man and was relegated to barbers and bootmakers; indeed, this attitude persists in part today, for many delegate forefoot surgery to the most junior and inexperienced surgical house officers.When C H Mayo, one of the famous Mayo brothers who founded the Mayo Clinic, read his paper on hallux valgus in 1920,13 a colleague was so surprised that he commented that it was strange that so celebrated a surgeon should consider the treat- ment of bunion an important procedure.The adage that there is no such thing as minor surgery, only minor surgeons, is alas still true.
Effects of pharmacologically-induced hypertension on myocardial ischemia and coronary hemodynamics in patients with fixed coronary obstruction.
Authors: H S Loeb, A Saudye, R P Croke, J V Talano, M L Klodnycky, R M Gunnar
Journal: Circulation (1978)

Twenty patients with fixed coronary artery obstruction were studied during rapid atrial pacing and methoxamine infusion. During pacing to heart rates of 142 +/- 4 (mean +/- SEM) beats per minute coronary sinus flow increased from 108 +/- 8 to 187 +/- 15 cc/min and myocardial oxygen consumption increased by + 80 +/- 11%. During methoxamine infusion that raised arterial systolic pressure to 196 +/- 5 mm Hg, similar increases in coronary sinus flow (to 179 +/- 13 cc/min) and myocardial oxygen consumption (+ 77 +/- 12%) occurred. Chest pain and ischemic ST segment changes developed in 17 and 14 patients respectively during atrial pacing, an incidence significantly greater (P less than 0.05) than during infusion of methoxamine (6 and 3 patients). Myocardial lactate extraction which averaged 26 +/- 4% during control was decreased to 10 +/- 8% during pacing and to 24 +/- 7% during methoxamine; the difference between decreases was not significant. The data show that at similar increases in myocardial oxygen consumption stress of increased heart rate results in more myocardial ischemia than stress of increased afterload.
Multiple pleural biopsy with the Abrams needle.
Authors: I P Mungall, P N Cowen, N T Cooke, T C Roach, N J Cooke
Journal: Thorax (1980)

Multiple pleural biopsies (up to 10) were taken with the Abrams needle through a single aspiration site in 55 patients with pleural effusions. A definite positive or suggestive pleural biopsy diagnosis was made in 33 patients (60%). In 32 of the 33 patients the pathological abnormality was confined to only a proportion of the biopsies. Pleural biopsies were positive or suggestive in 26 out of 36 patients (72%) eventually shown to have tumour and seven out of eight patients (88%) with tuberculosis. Small pneumothoraces occurred in four patients and surgical emphysema in two.