EVIDENCES FOR CLINICAL MAGNESIUM DEFICIENCY
Authors: E B FLINK, R McCOLLISTER, A S PRASAD, J C MELBY, R P DOE
Journal: Annals of Internal Medicine (1957)

Article1 November 1957EVIDENCES FOR CLINICAL MAGNESIUM DEFICIENCYEDMUND B. FLINK, M.D., F.A.C.P., ROBERT MCCOLLISTER, M.D., ANANDA S. PRASAD, M.D., JAMES C. MELBY, M.D., RICHARD P. DOE, M.D.EDMUND B. FLINK, M.D., F.A.C.P., ROBERT MCCOLLISTER, M.D., ANANDA S. PRASAD, M.D., JAMES C. MELBY, M.D., RICHARD P. DOE, M.D.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-47-5-956 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptWe shall attempt to present evidence that magnesium deficiency is a clinical problem, that it presents distinctive clinical features, and that it is not uncommon. A brief review of some of the facts about magnesium will be made and then evidence from the clinical course of patients, balance studies and correlation of findings will be presented.An adult human body weighing 70 kg. contains about 21.0 gm. of magnesium, according to Shohl,1and about 29 gm., according to Widdowson, McCance and Spray2and Duckworth and Warnock.3This discrepancy can be accounted for chiefly by differences in the skeletal content. Calculations...Bibliography1. Shohl AT: Mineral metabolism, 1939, Reinhold Publishing Co., New York, pp. 19, 20. Google Scholar2. WiddowsonMcCanceSpray EMRACM: The chemical composition of the human body, Clin. Sc. 10: 113-125, 1951. MedlineGoogle Scholar3. DuckworthWarnock JGM: The magnesium requirements of man in relation to calcium requirements, with observations on the adequacy of diets in common use, Nutrition Abstr. and Rev. 12: 167-183, 1942. Google Scholar4. GilderRedoBarrChild HSFDCG: Water distribution in normal subjects and in patients with Laennec's cirrhosis, J. Clin. Investigation 33: 555-564, 1954. CrossrefMedlineGoogle Scholar5. CotloveHollidaySchwartzWallace EMARWM: Effect of electrolyte depletion and acid-base disturbance on muscle cations, Am. J. Physiol. 167: 665-675, 1951. CrossrefMedlineGoogle Scholar6. Engbaek L: Pharmacological actions of magnesium ions, Pharmacol. Rev. 4: 396-410, 1952. MedlineGoogle Scholar7. SmithWinklerHoff PKAWHE: The pharmacological actions of parenterally administered magnesium salts, Anesthesiology 3: 323, 1942. CrossrefGoogle Scholar8. WhiteHandlerSmithStetten APELD: Principles of biochemistry, 1954, McGraw-Hill Book Co., New York. Google Scholar9. KruseOrentMcCollum HDEREV: Studies on magnesium deficiency in animals. I. Symptomatology resulting from magnesium deprivation, J. Biol. Chem. 96: 519-539, 1932. CrossrefGoogle Scholar10. TuftsGreenberg EVDM(a) : The biochemistry of magnesium deficiency. I. Chemical changes resulting from magnesium deprivation, J. Biol. Chem. 122: 693-714, 1938. (b) Tufts, E. V., and Greenberg, D. M.: The biochemistry of magnesium deficiency. II. The minimum magnesium requirement for growth, gestation and lactation and the effect of the dietary calcium level thereon, J. Biol. Chem. 122: 715-726, 1938. CrossrefGoogle Scholar11. Sjollema B: Nutritional and metabolic disorders in cattle, Nutrition Abstr. and Rev. 1: 621-632, 1932. Google Scholar12. FlinkStutzmanAndersonKonigFraser EBFLARTR: Magnesium deficiency after prolonged parenteral fluid administration and after chronic alcoholism complicated by delirium tremens, J. Lab. and Clin. Med. 43: 169-183, 1954. MedlineGoogle Scholar13. Flink EB: Magnesium deficiency syndrome in man, J. A. M. A. 160: 1406-1409, 1956. MedlineGoogle Scholar14. ColbyFrye RWCM(a) : A. Effect of feeding various levels of calcium, potassium and magnesium to rats, Am. J. Physiol. 166: 209, 1951. (b) Colby, R. W., and Frye, C. M.: B. Effect of feeding high levels of protein and calcium in rat rations on magnesium deficiency syndrome, Am. J. Physiol. 166: 408-412, 1951. CrossrefMedlineGoogle Scholar15. LowenhauptSchulmanGreenberg EMPDM: Basic histologic lesions of magnesium deficiency in rat, Arch. Path. 49: 427-433, 1950. Google Scholar16. Bird FH: Magnesium deficiency in chick: clinical and neuropathologic findings, J. Nutrition 39: 13-29, 1949. CrossrefMedlineGoogle Scholar17. BarronBrownPearson GPSOPB: Histologic manifestations of magnesium deficiency in rat and rabbit, Proc. Soc. Exper. Biol. and Med. 70: 220-223, 1949. CrossrefMedlineGoogle Scholar18. Neubuerger KT: The changing neuropathologic picture of chronic alcoholism, Arch. Path. 63: 1-6, 1957. Google Scholar19. SchraderPrickettSalmon GACOWD: Symptomatology and pathology of potassium and magnesium deficiency in rat, J. Nutrition 14: 85-109, 1937. CrossrefGoogle Scholar20. MooreHallmanScholl LAETLB: Cardiovascular and other lesions in calves fed diets low in magnesium, Arch. Path. 26: 820-838, 1939. Google Scholar21. BlaxterRookMacDonald KLJAAM: Experimental magnesium deficiency in calves. 1. Clinical and pathological observations, J. Comp. Path. and Therap. 64: 157-175, 1954. CrossrefGoogle Scholar22. WatchornMcCance ERA: Subacute magnesium deficiency in rats, Biochem. J. 31: 1379-1390, 1937. CrossrefMedlineGoogle Scholar23. DuckworthGodden JW: The lability of skeletal magnesium reserves. The influence of rates of bone growth, Biochem. J. 35: 816-823, 1941. CrossrefMedlineGoogle Scholar24. DuckworthGodden JW: The replenishment of depleted skeletal reserves of magnesium, Biochem. J. 37: 595-598, 1943. CrossrefMedlineGoogle Scholar25. KleiberBoelterGreenberg MMDDM: Fasting catabolism and food utilization of magnesium deficient rats, J. Nutrition 21: 363-372, 1941. CrossrefGoogle Scholar26. Garner RJ: Colorimetric determination of magnesium in plasma or serum by means of titan yellow, Biochem. J. 40: 828-831, 1946. CrossrefMedlineGoogle Scholar27. FitzgeraldFourman MGP: An experimental study of magnesium deficiency in man, Clin. Sc. 15: 635-647, 1956. MedlineGoogle Scholar28. ButlerTalbotBurnettStanburyMacLachlan AMNBCHJBE: Metabolic studies in diabetic coma, Tr. A. Am. Physicians 60: 102-109, 1947. MedlineGoogle Scholar29. NabarroSpencerStowers JDAGJM: Metabolic studies in severe diabetic ketosis, Quart. J. Med. 21: 225-248, 1952. MedlineGoogle Scholar30. MartinWertman HEM: Serum potassium, magnesium, and calcium levels in diabetic acidosis, J. Clin. Investigation 26: 217-228, 1947. CrossrefMedlineGoogle Scholar31. DuckworthGoddenWarnock JWGM: The effect of acute magnesium deficiency on bone formation in rats, Biochem. J. 34: 97-108, 1940. CrossrefMedlineGoogle Scholar32. GreenbergTufts DMEV: The nature of magnesium deficiency, Am. J. Physiol. 121: 416-423, 1938. CrossrefGoogle Scholar33. HirschfelderHaury ADVG: Clinical manifestations of high and low plasma magnesium, J. A. M. A. 102: 1138-1141, 1934. CrossrefGoogle Scholar34. Miller JF: Tetany due to deficiency in magnesium, Am. J. Dis. Child. 67: 117-119, 1944. CrossrefGoogle Scholar35. SuterKlingman CWO: Neurologic manifestations of magnesium depletion states, Neurology 5: 691-699, 1955. CrossrefMedlineGoogle Scholar36. LeveyAbbottKriegerDavis SWEHJH: Metabolic alterations in surgical patients. VIII. Studies involving iron and magnesium metabolism in patients with gastrointestinal drainage, J. Lab. and Clin. Med. 47: 437-443, 1956. MedlineGoogle Scholar37. MaderIseri IJLT: Spontaneous hypopotassemia, hypomagnesemia, alkalosis and tetany due to hypersecretion of a corticosterone-like mineralocorticoid, Am. J. Med. 19: 976-988, 1955. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: EDMUND B. FLINK, M.D., F.A.C.P.; ROBERT MCCOLLISTER, M.D.; ANANDA S. PRASAD, M.D.; JAMES C. MELBY, M.D.; RICHARD P. DOE, M.D.Affiliations: Minneapolis, Minnesota*Presented at the Thirty-eighth Annual Session of The American College of Physicians, Boston, Massachusetts, April 12, 1957.From the Medical Service of the Veterans Hospital, Minneapolis, Minnesota, and the Department of Internal Medicine, The University of Minnesota.Requests for reprints should be addressed to Edmund B. Flink, Veterans Hospital, Minneapolis 14, Minn. 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