STUDIES IN PERNICIOUS ANEMIA: AN INQUIRY INTO THE RÔLE OF PEPSIN
Authors: Samuel Morrison
Journal: Annals of Internal Medicine (1940)

Article1 August 1940STUDIES IN PERNICIOUS ANEMIA: AN INQUIRY INTO THE RÔLE OF PEPSINSAMUEL MORRISON, M.D., F.A.C.P.SAMUEL MORRISON, M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-14-2-242 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptIn a paper on the mechanism of therapy in pernicious anemia, Greenspon1 suggested that an "extrinsic factor" as conceived by Castle was unnecessary and that an antianemic principle protected from the inactivating effect of pepsin, such as beef (or other source of "extrinsic factor") was solely essential. This suggestion coincided with our belief that antipernicious anemia potency may be attributed to the fundus as well as to other portions of the stomach, and that this potency is ordinarily neutralized by the action of pepsin, a product primarily of the fundus. Greenspon's contention if confirmed will strongly support our belief.It...References1. GREENSPON EA: The nature of the antipernicious anemia principle in stomach, Jr. Am. Med. Assoc., 1936, cvi, 266. CrossrefGoogle Scholar2. MEULENGRACHT E: The glands of the stomach in relation to pernicious anemia; with special reference to the glands in the pyloric region, Proc. Roy. Soc. Med., 1935, xxviii, 37. Google Scholar3. UNGLEYMOFFETT CCR: Observations on Castle's intrinsic factor in pernicious anemia, Lancet, 1936, ccxxx, 1232. CrossrefGoogle Scholar4. HANESHANSEN-PRÜSSEDWARDS FMOCSW: The feeding of modified gastric juice in pernicious anemia, Jr. Am. Med. Assoc., 1936, cvi, 2058. CrossrefGoogle Scholar5. FITZ-HUGHCRESKOFF TAS: Experiments with "depepsinized" human gastric juice in the treatment of pernicious anemia, Am. Jr. Med. Sci., 1936, cxcii, 168. CrossrefGoogle Scholar6. CASTLEHAM WBTH: Observations on the etiologic relationship of achylia gastrica to pernicious anemia, Jr. Am. Med. Assoc., 1936, cvii, 1456. CrossrefGoogle Scholar7. LIM RK: A method for recording gastric secretion in acute experiments on normal animals, Quart. Jr. Exper. Physiol., 1922-23, xiii, 71. The question of a gastric hormone, Quart. Jr. Exper. Physiol., 1922-23, xiii, 79. CrossrefGoogle Scholar8. HENNINGBRUGSCH NH: Ueber die Verteilung des antianämischen Faktors in der Magenschleimhaut, Deutsch. med. Wchnschr., 1931, lvii, 757. CrossrefGoogle Scholar9. GUTZEITHERRMANN KJ: The effect of stomach substance on pernicious anemia (natural gastric juice, pyloric and fundic mucosa, wall of the small intestine), München. med. Wchnschr., 1931, lxxviii, 266. Google Scholar10. HENNINGSTIEGER NG: Die Behandlung der perniziösen Anämie mit Magenschleimhautpräparaten, Klin. Wchnschr., 1930, ix, 2145. CrossrefGoogle Scholar11. HENNING N: Ueber den Ursprung des Antiperniziosa-Prinzips, Med. Welt, 1934, viii, 1145. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Baltimore, Maryland*Received for publication June 23, 1937.In pursuing these studies I have had the cooperation of Dr. Holmes of the University Hospital, Drs. Edwards and Myers of the Church Home and Infirmary, Drs. Rainy, Wyrens and DeSautelle of the City Hospitals, Dr. Freeman of the Mercy Hospital and Dr. Levi of St. Joseph's Hospital, Baltimore. Thanks are also due to Dr. Anderson, Director of the Squibb Laboratories, for his willingness to prepare and supply the depepsinized preparations used in these studies.The expenses of this investigation were defrayed in part by a grant from the Julius Friedenwald Research Fund of the University of Maryland, School of Medicine. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 August 1940Volume 14, Issue 2Page: 242-254KeywordsAnemiaPepsinsPernicious anemiaResearch fundingStomach ePublished: 1 December 2008 Issue Published: 1 August 1940 PDF downloadLoading ...