tbuckley/cabot-search huggingface dataset:
Effects of physical training on exercise blood flow and enzymatic activity in skeletal muscle
Authors: E. Varnauskas, P. Bjorntorp, M. Fahlen, I. Prerovsky, J. Stenberg
Journal: Cardiovascular Research (1970)

Journal Article Effects of physical training on exercise blood flow and enzymatic activity in skeletal muscle Get access E. Varnauskas, E. Varnauskas From the Division of Cardiology, Medical Department I, Sahlgrenska Sjukhuset, University of Gothenburg, Gothenburg, Sweden Search for other works by this author on: Oxford Academic PubMed Google Scholar P. Björntorp, P. Björntorp From the Division of Cardiology, Medical Department I, Sahlgrenska Sjukhuset, University of Gothenburg, Gothenburg, Sweden Search for other works by this author on: Oxford Academic PubMed Google Scholar M. Fahlén, M. Fahlén From the Division of Cardiology, Medical Department I, Sahlgrenska Sjukhuset, University of Gothenburg, Gothenburg, Sweden Search for other works by this author on: Oxford Academic PubMed Google Scholar I. Přerovský, I. Přerovský 2 From the Division of Cardiology, Medical Department I, Sahlgrenska Sjukhuset, University of Gothenburg, Gothenburg, Sweden 2Present address: Cardiovascular Research Institute, Prague, Czechoslovakia. Search for other works by this author on: Oxford Academic PubMed Google Scholar J. Stenberg J. Stenberg From the Division of Cardiology, Medical Department I, Sahlgrenska Sjukhuset, University of Gothenburg, Gothenburg, Sweden Search for other works by this author on: Oxford Academic PubMed Google Scholar Cardiovascular Research, Volume 4, Issue 4, October 1970, Pages 418–422, https://doi.org/10.1093/cvr/4.4.418 Published: 01 October 1970 Article history Accepted: 19 January 1970 Published: 01 October 1970
Hysteria, hysterectomy, and anti-NMDA receptor encephalitis: a modern perspective on an infamous chapter in medicine
Authors: T. A. Pollak
Journal: BMJ (2013)

The presumed relationship between the female reproductive organs and states of insanity casts a dark shadow over the history of medicine. It perhaps reached its grim apotheosis in the late 1800s, when gynaecologists conducted hysterectomies, oophorectomies, and clitoridectomies for all manner of nervous diseases.

As all students of psychiatry are taught, “hysteria” shares its origin with the Greek word for womb, and it was with dysfunction of the reproductive organs that the origins of the peculiar emotional states and bizarre …
A Protective Anti-Inflammatory Phenotype in High-Risk Individuals Who Do Not Develop Coronary Artery Disease
Authors: Torbjørn Holm, Thor Ueland, Bente Halvorsen, Aina Hognestad, Anne G.V. Holm, Ragnhild Wergeland, Lars Gullestad, Pål Aukrust, John Kjekshus
Journal: Journal of the American College of Cardiology (2006)
Abstract 141: Identification of a gene silenced in rat mammary carcinomas by combination of DNA methylation microarray and chemical genomic screening
Authors: Naoko Hattori, Eriko Okochi-Takada, Satoshi Yamashita, Naoko Watanabe, Toshikazu Ushijima
Journal: Cancer Research (2010)

Abstract Aberrant DNA methylation is deeply involved in the development and progression of human breast cancers, but its inducers and molecular mechanisms are still unclear. To reveal such inducers and analyze molecular mechanisms of methylation induction, animal models are indispensable. However, genes methylation-silenced in the animal models of breast cancer are unknown, and identification of inducers and analysis of mechanisms are hampered. Here, to identify genes methylation-silenced in rat primary mammary carcinomas, we took a combined approach of methylated DNA immunoprecipitation (MeDIP)-CpG island (CGI) microarray and chemical genomic screening. MeDIP-CGI microarray analysis of a carcinoma cell line induced by 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) revealed that, among 4,680 promoter CGIs analyzed, 664 were methylated in the cell line. Sixty-two of the 664 genes were re-expressed by treatment of the cell line with 5-aza-2’-deoxycytidine and trichostatin A. An unmethylated status in normal mammary glands was confirmed for 31 of the 62 genes by MeDIP-CGI microarray analyses of a pool of 4 normal mammary glands. Among 13 primary mammary carcinomas induced by PhIP, five of the 31 genes were methylated in one carcinoma or more. Among 12 primary carcinomas induced by 7,12-dimethylbenz[a]anthracene, methylation of all the five genes was also observed. RT-PCR analysis revealed that one of the five genes had high expression in normal mammary glands, but low expression in carcinomas, showing that this gene was methylation-silenced in rat primary mammary carcinomas. In humans, the gene was expressed in mammary epithelial cells that had unmethylated DNA, and was down-regulated in three cancer cell lines that had methylated DNA. The gene was methylated in about 9% of 80 primary human breast cancers, and it was suggested that aberrant DNA methylation of this gene was a common event between rat and human breast cancers. This is the first study of genome-wide DNA methylation analysis using rat mammary carcinomas, and the methylation-silenced gene, along with the other methylated genes, is expected to be useful as a marker in identifying inducers of aberrant DNA methylation and analyzing its molecular mechanisms. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 101st Annual Meeting of the American Association for Cancer Research; 2010 Apr 17-21; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2010;70(8 Suppl):Abstract nr 141.
Human Influenza: Aspects of the Immune Response to Vaccination
Authors: Julius A. Kasel, Roger D. Rossen, Robert V. Fulk, David S. Fedson, Robert B. Couch, Paul Brown
Journal: Annals of Internal Medicine (1969)

The studies presented in this Conference illustrate some of the newer aspects of the immune response to infection with influenza virus and vaccination with inactivated vaccines. The predominant immunoglobulin in respiratory secretions is an 11S IgA dimer that is distinguishable from serum IgA. Intranasal immunization with inactivated vaccines resulted in higher titers and greater duration of antibody in respiratory secretions than did subcutaneous vaccination. In addition, if given in adequate dosages, vaccination by this method resulted in significant levels of humoral antibody in most vaccinees. The degree of both serum and nasal antibody responses was shown to be related to the age and prior immunologic experience of the vaccinated individual. Initial studies from challenge experiments suggested that intranasal vaccination was as effective as subcutaneous vaccination in reducing infection.
EARLY DIAGNOSIS AND TREATMENT OF CONGENITAL DISLOCATION OF THE HIP
Authors: JOSEPH A. FREIBERG
Journal: JAMA (1934)

The early diagnosis of congenital dislocation of the hip is not difficult, even in the hands of physicians inexperienced in orthopedic surgery. It is true that in the normally adipose child it is rather difficult to palpate the femoral head, whether it is dislocated or not. On the other hand, there are several signs that should suggest some abnormality about the hip joint and warrant a roentgen examination. After a roentgen examination has been made there should be no question whatever concerning the diagnosis. In discussing the early diagnosis of dislocation of the hip, the etiologic factors must be considered first. Of the many hypothetic explanations as to why a hip should be dislocated at the time of birth, none seem entirely satisfactory. Excluding the factor of trauma, because of the frequent existence of the deformity in children born of multiparas following normal delivery, an anatomic explanation must be found.
Effect of weight reduction in moderately overweight patients on recorded ambulatory blood pressure and free cytosolic platelet calcium.
Authors: U Scherrer, J Nussberger, S Torriani, B Waeber, R Darioli, J R Hofstetter, H R Brunner
Journal: Circulation (1991)

Although platelet cytosolic calcium has been shown to decrease during pharmacological treatment of hypertension, there is no evidence that cytosolic calcium also falls during a nonpharmacological reduction in blood pressure. To provide such evidence, we examined prospectively the relation between platelet cytosolic calcium and ambulatory blood pressure during weight reduction in moderately overweight (body mass index [BMI] greater than 25), mildly hypertensive individuals. The experimental group (responders: BMI reduction greater than 5%) consisted of 19 patients who lost 8.5 +/- 2.9 kg (mean +/- SD, p less than 0.05) during a 10-week hypocaloric diet, whereas the control group (nonresponders: BMI reduction less than 5%) consisted of 12 patients who showed no relevant change in body weight (-2.0 +/- 1.3 kg) during the same period of time. The moderate weight loss of the responders decreased blood pressure by 14/5 mm Hg (p less than 0.05), as measured by ambulatory monitoring, which renders a placebo effect unlikely. This nonpharmacological reduction in blood pressure was accompanied by a proportional 11% decrease (p less than 0.05) in platelet cytosolic calcium and also by significant (p less than 0.05) decreases in plasma catecholamines and serum cholesterol. These findings establish the concept of a nonpharmacological reduction in free cytosolic platelet calcium in humans and add further evidence suggesting a link between intracellular calcium homeostasis and blood pressure regulation.
The R620W polymorphism in PTPN22 confers general susceptibility for the development of alopecia areata
Authors: R.C. Betz, K. König, A. Flaquer, S. Redler, S. Eigelshoven, A.-K. Kortüm, S. Hanneken, A. Hillmer, T. Tüting, J. Lambert, J. De Weert, R. Kruse, G. Lutz, B. Blaumeiser, M.M. Nöthen
Journal: British Journal of Dermatology (2007)

Background The functional R620W (c.1858C>T) variant of the protein tyrosine phosphatase nonreceptor 22 gene (PTPN22) has been associated with a variety of autoimmune disorders. A recent study has suggested that R620W also contributes to the severe form of alopecia areata (AA). Objectives We sought to replicate the finding of an association between PTPN22 and severe AA. In addition, we wanted to study the effect of PTPN22 on the general risk to develop AA and on other subtypes of AA (mild AA, early/late age at onset, positive/negative family history). Methods The R620W variant was genotyped in a large case–control sample of Belgian–German origin with 435 patients and 628 controls. Results Significant results were obtained for the overall collective of patients with AA (P =0·007). Subdividing the sample according to severity of AA, family history and age at onset, we detected lowest P‐values for patients with the severe form of AA (Pcorr = 0·036), with a positive family history (Pcorr = 0·042) and with an age at onset ≤ 20 years (Pcorr = 0·048). Conclusions Our results suggest the R620W variant of PTPN22 as a general risk factor in AA with the strongest effect observed among patients with a severe type of AA, a positive family history or an early onset of disease.
Group Advises Clinicians to Routinely Screen Women for Sexual Assault History
Authors: B. M. Kuehn
Journal: JAMA (2011)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Abstract P1-01-03: Comparison of sentinel lymph node biopsy guided by the multi-modal method of indocyanine green fluorescence, radioisotope and blue dye versus the radioisotope in breast cancer; A randomized phase II trial
Authors: S-Y Jung, S-K Kim, SW Kim, S Lee, J Lee, I-s Shin, Y Kwon, E Lee
Journal: Cancer Research (2012)

Abstract Background: Sentinel lymph node (SLN) biopsy is a standard surgery for axillary staging of early breast cancer. This study aimed to evaluate the identification rate and surgery time of SLN biopsy with the multi-modal method using the mixture of indocyanine green (ICG) fluorescence, RI and blue dye as a new method, in comparison with the RI, in clinically node negative breast cancer patients. Materials and methods: In this phase-II randomized study, 86 patients with clinically node negative breast cancer were randomized to receive periareolar injection of the mixture including ICG fluorescence, RI and blue dye or the only RI for SLN biopsy. We compared the identification rate, the number of SLN, and detections time of SLN biopsy between these two groups. Results: The mean age of the multimodal group and the only RI group was 48.2 years and 51.0 years (p = 0.12), respectively. There were no differences of histopathologic factors including tumor size, node positivity, hormone receptor positivity and HER2 positivity between two groups. Sentinel lymph nodes were identified in all patients of both groups (100% in the multimodal group vs 100% in the RI group). The average number of SLN in the mixture group was more than that of the RI group (3.4 ±1.37 vs 2.3 ± 1.04; p &amp;lt; 0.001). The time to excise the first SLN was similar in each group (6.5 ± 5.16 min vs 8.0 ± 4.35 min; p = 0.13). In multimodal group, percutaneous lymphatic drainage was visualized by fluorescent imaging in 90.7% (39 of 43 patients) and all of the first SLN were detected by both ICG fluorescent and RI. After operation, there was no complication including skin staining or necrosis. Conclusions: This study is the first randomize trial which compared the multimodal method using the mixture of ICG fluorescence, RI and blue dye and the conventional RI method for SLN biopsy. The multimodal method is an available method for SLN biopsy, which allows percutaneous visualization of lymphatic vessels and intraoperative lymph node detection. Citation Information: Cancer Res 2012;72(24 Suppl):Abstract nr P1-01-03.
Hypoxia Suppresses Symptom Perception in Asthma
Authors: Danny J. Eckert, Peter G. Catcheside, Janet H. Smith, Peter A. Frith, R. Doug McEvoy
Journal: American Journal of Respiratory and Critical Care Medicine (2004)

Any factor that inhibits the ability of an individual with asthma to recognize their symptoms appropriately may contribute to treatment delay, "near miss" events, and death during acute severe asthma. The purpose of this study was to investigate the effects of two common features of acute severe asthma--hypoxia and hypercapnia--on respiratory sensation. Sixteen individuals with stable asthma were exposed to three gas conditions (34 minutes each): isocapnic hypoxia (arterial blood O2 saturation of approximately 80%), hypercapnia (increase in end-tidal CO2 of approximately 5-10 Torr), or isocapnic normoxia on 3 separate days. The perceived magnitude of externally applied resistive loads, measured during each gas condition, was reduced throughout hypoxia compared with normoxia, and there was a trend for a progressive decline during hypercapnia. Within the 15-minutes postgas inhalation period, methacholine-induced symptoms of difficult breathing, chest tightness, and breathlessness, measured using modified Borg scales, were 25-30% lower after hypoxia compared with normoxia but were not reduced after hypercapnia. We conclude that 30 minutes of sustained hypoxia and possibly hypercapnia impair sensations of respiratory load and that the effects of hypoxia persist for at least 10 minutes after returning to normoxia.
Interferons: Potential Problems
Authors: Alastair E. Cribb
Journal: JAMA (1992)

<h3>To the Editor.</h3> —The recent review of the interferons by Baron et al<sup>1</sup>provides an excellent summation of their mechanisms of action and clinical applications. We would like to point out a potential adverse drug interaction that may be associated with interferon therapy in some individuals on concurrent medications. It has been known since 1976 that interferon-inducing agents can suppress cytochrome P-450—dependent drug metabolism in rodents.<sup>2</sup>Subsequently, the induction of interferon during viral infections was implicated in the development of theophylline toxicity in human asthmatics.<sup>3,4</sup>Interferon depresses antipyrine and theophylline clearance in humans,<sup>5,6</sup>and it has recently been confirmed by the use of hepatic biopsy that the decreased clearance of some drugs seen during interferon therapy is due to the suppression of hepatic cytochrome P-450—dependent drug metabolism.<sup>7</sup> The extent to which drug metabolism is depressed in response to interferon varies widely between individuals.<sup>7</sup>It
Prediction of Respiratory-Distress Syndrome by Shake Test on Newborn Gastric Aspirate
Authors: Jerry J. Evans
Journal: New England Journal of Medicine (1975)

NEWBORN intensive-care units have made great strides in treatment of premature infants with respiratory-distress syndrome. Although many such infants can adequately be handled by pediatricians in intermediate-care nurseries, transfer of certain infants with severe respiratory-distress syndrome to special-care nurseries is sometimes delayed, in the hope that they will run the classic self-limited course. Since survival of these infants is partially dependent on early application of appropriate and sophisticated care, it would be helpful to have a simple test to distinguish which babies are deficient in pulmonary surfactant. These babies could then be transferred to the regional intensive-care unit very soon . . .
New Approach to Myasthenia Gravis
Authors: Marsha F. Goldsmith
Journal: JAMA (2001)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Alcoholism in industry
Authors: P. Thurber
Journal: JAMA (1971)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Balloon dilation of mitral stenosis in adult patients: Postmortem and percutaneous mitral valvuloplasty studies
Authors: Raymond G. McKay, James E. Lock, Robert D. Safian, Patricia C. Come, Daniel J. Diver, Donald S. Baim, Aaron D. Berman, Sanford E. Warren, Valerie E. Mandell, Henry D. Royal, William Grossman
Journal: Journal of the American College of Cardiology (1987)
Change at JAMA
Authors: F. J. Ingelfinger
Journal: New England Journal of Medicine (1973)

A case of septic induced abortion in a 15-year-old girl referred to the hospital as a pediatric patient with the provisional diagnosis of meningococcemia is reported. The patient was admitted in shock, cyanotic, and vasoconstricted. Pertinent comments by the nurses that the patient admitted coitus 12 to 14 weeks previously and followed by amenorrhea, were apparently ignored. The 1st gynecologic consultant was called after the patient experienced severe cramps and passage of part of a placenta. He recommended intravenous oxytocin and curettage, but this advice was not followed because the hospital pharmacy did not stock oxytocin and because the administration would not permit curettage on a child. Dilation and curettage was performed after transfer to a general hospital. The patient died 6 weeks after admission, and the pathologist's final summary noted that extensive pneumonia together with organizing thrombi suggest that the patient may have thrown septic emboli very early in the course of her disease. It is concluded that errors and omissions were disastrous, but even more reprehensible was the failure of residents to credit nurses' notes or follow consultants' recommendations which clearly pointed all along to the correct diagnosis. Finally, when the patient aborted in bed, the urgency of intervention was not recognized and the time which was her last chance for survival was lost.
INTRODUCTION OF COCCIDIOIDAL GRANULOMA INTO CHICAGO
Authors: EDWIN F. HIRSCH
Journal: JAMA (1923)

Coccidioidal granuloma, a disease in many ways resembling blastomycosis and tuberculosis, but entirely distinct from them, results from infection withCoccidioides immitis, a mold of theAscomycetesgroup. Since the first report of this disease by Wernicke1and Posadas2from Buenos Aires in 1892, which to date seems to be the only instance mentioned outside North America, there have been recorded about fifty additional cases, most of them from California. Rixford and Gilchrist3in 1896 reported the first two cases from California, and regarded as protozoon parasites the spherical-shaped organisms present in the tissues, the confusion having been introduced by Wernicke and Posadas in the original descriptions of the disease. Ophuls and Moffitt,4in 1900, however, demonstrated by cultures of organisms taken from lesions that the causal agent is a mold. Excellent summaries of the disease have been made from time to time by Hektoen,5