STUDIES IN DISORDERS OF MUSCLE. II. CLINICAL MANIFESTATIONS AND INHERITANCE OF FACIOSCAPULOHUMERAL DYSTROPHY IN A LARGE FAMILY
Authors: F H TYLER, F E STEPHENS
Journal: Annals of Internal Medicine (1950)

Article1 April 1950STUDIES IN DISORDERS OF MUSCLE. II. CLINICAL MANIFESTATIONS AND INHERITANCE OF FACIOSCAPULOHUMERAL DYSTROPHY IN A LARGE FAMILYFRANK H. TYLER, M.D., F. E. STEPHENS, Ph.D.FRANK H. TYLER, M.D., F. E. STEPHENS, Ph.D.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-32-4-640 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptINTRODUCTIONA study has been made of a large kindred†of which many members are known to have weakness and muscular atrophy. The individual family groups of this kindred are large and in some cases are of polygamous origin. This has presented an unusual opportunity for the study of the abnormality in a large group of patients, all of whom derived the trait from the same source; and to see the trait as it occurred at different ages and in different degrees of expression. A clinical description of the disease is presented as well as the pattern of its inheritance....Bibliography1. Alway RH: Prevalence of heart disease in high school students in Salt Lake City, Reported at American Public Health Association, Boston, Mass., November, 1948. Google Scholar2. LandouzyDéjerine LJ: De la myopathie atrophique progressive, Rev. méd. franç. 5: 81, 1885; 5: 253, 1885; 6: 977, 1886. Google Scholar3. EulenbergCohn AT: Inheritance of facioscapulohumeral dystrophy, Neurol. Centralbl. 30: 963, 1911. Google Scholar4. Weitz W: Über die Vererung bei der Muskeldystrophie, Deutsch. Ztschr. f. Nervenheilk. 72: 143, 1921. CrossrefGoogle Scholar5. Niwa C: Proc. Imp. Acad. Japan 5: 287, 1929. CrossrefGoogle Scholar6. MinkowskiSidler MA: Klinische und genealogische Untersuchungen, Arch. Julius Klaus-Stiff 3: 239, 1928. Google Scholar7. Robinson AA: Familial myopathy, M. J. and Rec. 121: 76, 1925. Google Scholar8. Unpublished data. Google Scholar9. TylerWintrobe FHMM: Studies in disease of muscle. I. The problem of progressive muscular dystrophy, Ann. Int. Med. 32: 72-79, 1950. LinkGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: *Received for publication June 21, 1949.From the Laboratory for the Study of Hereditary and Metabolic Disorders and the Departments of Medicine and Biology, University of Utah.This study was supported in part by a grant from the United States Public Health Service.†"Kindred" is used here in the genetic sense and refers to all persons descended from a single individual. "Family" is used in a more restricted sense and refers to a group of siblings and their parents. 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STEPHENS, Ph.D.The Incidence and Heredity of Muscular Dystrophy 1 April 1950Volume 32, Issue 4Page: 640-660KeywordsAtrophyGeneticsMedical servicesMetabolic disordersMusclesResearch laboratories ePublished: 1 December 2008 Issue Published: 1 April 1950 PDF downloadLoading ...