tbuckley/cabot-search huggingface dataset:
Abstract 4505: Presentation To Non-PCI Center Is Major Modifiable Factor Associated With Delayed Door-to-balloon Time In HORIZONS-AMI
Authors: James C Blankenship, Thomas D Scott, Kimberly A Skelding, Peter B Berger, Helen Parise, Bruce R Brodie, Bernard Witzenberger, Giulio Gaugliumi, Jan Z Peruga, Alexandra J Lansky, Roxana Mehran, Gregg W Stone
Journal: Circulation (2008)

Introduction: Many pts with STEMI receive reperfusion later than recommended by current guidelines. Hypothesis: Factors associated with delayed door-to-balloon times (D2B) can identified; some may be modifiable. Methods: In the HORIZONS-AMI study, 3602 pts within 12 hours of onset of STEMI undergoing primary PCI were prospectively enrolled. Times were recorded for onset of symptoms, arrival at PCI center, arrival in catheterization laboratory, and first balloon inflation. Pts transferred from a non-PCI center to a PCI center were considered separately from pts presenting initially to a PCI center. Logistic regression using 29 demographic/historic variables and 6 pre-PCI adverse events (arrhythmias, CPR, hypotension, respiratory failure) identified factors associated with (1) first door-to-balloon time &gt; 90 minutes, and (2) for each time interval, the highest quintile. Results: Complete time data was available for 2639 pts. Of 1848 pts presenting directly to a PCI center, 55% had D2B &lt; 90 minutes. Of 781 pts transferred from a non-PCI center to a PCI center, 12% had D2B&lt; 90 minutes. Presentation to a non-PCI center was the strongest predictor of D2B &gt; 90 minutes (OR 9.1 compared to presentation to a PCI center, p &lt; .0001). Other predictors of D2B &gt; 90 minutes included history of congestive heart failure (OR 2.1, p = 0.0133), diabetes (OR 1.45, p = 0.002), prior MI (OR 1.43, p = 0.046), and baseline diuretic use (OR 1.36, p = 0.042), but not pre-PCI adverse events. Demographic factors correlated only weakly with delays in milestones between presentation and balloon inflation. Median D2B was similar for US (91 minutes) versus non-US pts (101 minutes, p = NS). After arrival at the cath lab, balloon inflation was delayed 1 hour (p &lt; 0.001) in pts with prior CABG compared to pts without prior CABG. Conclusions: In HORIZONS-AMI, D2B &lt; 90 minutes was achieved in only one half of pts presenting to a PCI center and one tenth of pts presenting to a non-PCI center. The only potentially modifiable factor observed in this study was presentation to a non-PCI center. This data highlights the need for ambulance triage of pts with chest pain to bypass non-interventional centers and deliver pts directly to primary PCI centers of excellence.
Abstract 13557: Tolvaptan Improves Water Retention in Children Especially with Single Ventricle Physiology
Authors: Mikiko Shimizu, Tetsuko Ishii, Sadamitsu Yanagi, Yoshihiko Kurita, Satoshi Yasukochi, Masaki Nii, Shinichi Ohtsuki, Toshio Nakanishi
Journal: Circulation (2013)

Background: Tolvaptan, V2 receptor antagonist, is a new diuretics which has been shown to be effective in adult heart failure (HF) and hyponatulamia. However, little is known about safety and effic...
Effects of dopamine agonists in tardive dyskinesia
Authors: R. C. Smith, C. A. Tamminga, J. Haraszti, G. N. Pandey, J. M. Davis
Journal: American Journal of Psychiatry (1977)

The authors used a combined behavioral and neuroendocrinological strategy to investigate the relevance of abnormalities in the brain dopaminergic systems to the pathophysiology of tardive dyskinesia by assessing the effects of apomorphine, a directly acting dopamine agonist, and d-amphetamine, an indirectly acting dopamine agonist, in patients with tardive dyskinesia. Administration of I.V. d-amphetamine increased dyskinetic movements in most patients with tardive dyskinesia, a finding consistent with the dopaminergic hypothesis. Contrary to predictions based on animal models, apomorphine did not increase dyskinetic movements in these patients but instead substantially reduced dyskinesia in some patients. Patients with tardive dyskinesia did not have a greater drop in serum prolactin or a greater rise in serum growth hormone after apomorphine than normal or chronic schizophrenic subjects without tardive dyskinesia.
Abstract 16558: Endothelial Cell Transfusion Protects Against Chronic Kidney Disease-Induced Endothelial Dysfunction in Nephrectomized Rats
Authors: Fadi G Hage, Robert Hilgers, Peng Li, Zhengqin Yang, Suzanne Oparil, Yiu-Fai Cehn
Journal: Circulation (2011)

Introduction: Chronic kidney disease (CKD) is associated with increased cardiovascular morbidity and mortality. We studied whether transfusion of endothelial cells (ECs) 6 wks after 5/6 nephrectomy...
Comparative Notes on Rotheln, Measles, and Scarlatina
Authors: C. H. Brown
Journal: BMJ (1887)

In'the second group of fifteen women, in whom there had been one pregnancy within a short time of marriage, we assume, of course, that at the time of marriage their probreative machinery was intact.In all but two of these cases the story of pelVic peritonitis following their only labour placed them clearly in tho group in which puerperal mis- chief had to be regarded as the cause.In the exceptional two the author, believed that he failed to get the history rather from the stupidity of the patients than from an absence of the facts.A third 'group was readily 'formed 'of fourteen women whose fecundity was not limited to one child.In this group were found the most acute and severe cases.At least eight of these women suffered from sub-acute, or even acute gonorrhoeal salpingitis of comparatively recent origin, the average titne which had elapsed between the last pregnancy and the operation being three years.On the other hand in the,six other women in this grnop in whom the author could get no such history (or doubtfully in two of them) fourteen years had, on the average, elapsed between their last confinement land the date of the operation.These facts had a strikirtg pathological significance.Thb characteristics of the diA1 d-&pp6ndages in the second group bf cases were strikingly different frdi.'those of the cases of long stand.ing, and' there could be.no doubt' that the changes known in other organs in the various stages of the inflammatory process were exemplifled here.In the acute or early stAge the appendages were intensely congested and swollen, and were very friable.'In fact, it was a matter of difficulty to remove' them entire.In the old standing cases the organs were con- tracted and atrophied, and few, if any, traces of normal follicles could be discovered in the cirrhotic and 'densely adherent ovaries.At this stage the tubes generally contained rer,y little fluid, and their contents
Abstract 16417: Bone Marrow Transplants From NOX2-Deficient Mice To WT Mice Protect Against Diabetes-Induced Vascular Endothelial Dysfunction Through Decreased Arginase Activity
Authors: lin yao, Zhimin Xu, Modesto Rojas, Ruth B Caldwell, Robert W Caldwell
Journal: Circulation (2011)

Increased arginase activity has been implicated in diabetes-induced vascular dysfunction by reducing L-arginine bioavailability and nitric oxide production. Our lab previously reported that inhibit...
Abstract 12272: Ultrasound Mediated Renal Sympathetic Denervation
Authors: Todd J Brinton, Tom Anderson, Jimin Zhang, Michael E Gertner
Journal: Circulation (2011)

The renal sympathetic nerves have been identified as a major contributor to the complex physiology of hypertension in both experimental models and humans. Renal Sympathetic Denervation (RSD) has be...
Abstract 14911: The Impact of LV Dilatation on Mortality in Heart Failure with Preserved Ejection Fraction: Implications for Current Heart Failure Guidelines
Authors: Gillian Whalley, Katrina Poppe, Nikki Earle, Christophe Tribouilloy, Mark Kearney, Luigi Tarantini, Stella Macin, Mattie Lenzen, Antoni Bayes-Genis, Isreal Gotzman, Martin Cowie, Robert Doughty
Journal: Circulation (2010)

Background: Patients (pts) with heart failure (HF) may present with either preserved (>50%) or low ejection fraction (HF-PEF or HF-lowEF). This is a prognostically important differentiation: a larg...
The UCLA-University of Utah epidemiologic survey of autism: recurrence risk estimates and genetic counseling
Authors: E R Ritvo, L B Jorde, A Mason-Brothers, B J Freeman, C Pingree, M B Jones, W M McMahon, P B Petersen, W R Jenson, A Mo
Journal: American Journal of Psychiatry (1989)

The authors recently reported, in this journal, an epidemiologic survey of autism in Utah. Twenty (9.7%) of the 207 families ascertained had more than one autistic child. Analyses of these data revealed that autism is 215 times more frequent among the siblings of autistic patients than in the general population. The overall recurrence risk estimate (the chance that each sibling born after an autistic child will develop autism) is 8.6%. If the first autistic child is a male the recurrence risk estimate is 7%, and if a female 14.5%. These new recurrence risk estimates should be made available to all individuals who have autistic children and are interested in family planning.
Ferroquine and artesunate in African adults and children with Plasmodium falciparum malaria: a phase 2, multicentre, randomised, double-blind, dose-ranging, non-inferiority study
Authors: Jana Held, Christian Supan, Carmen L O Salazar, Halidou Tinto, Léa N Bonkian, Alain Nahum, Bancole Moulero, Ali Sié, Boubacar Coulibaly, Sodiomon B Sirima, Mohamadou Siribie, Nekoye Otsyula, Lucas Otieno, Ahmed M Abdallah, Robert Kimutai, Marielle Bouyou-Akotet, Maryvonne Kombila, Kimiko Koiwai, Cathy Cantalloube, Chantal Din-Bell, Elhadj Djeriou, John Waitumbi, Benjamin Mordmüller, Daniel Ter-Minassian, Bertrand Lell, Peter G Kremsner
Journal: The Lancet Infectious Diseases (2015)
Abstract 1792: Multiple Biomarker Utilization for Detection of Myocardial Infarction Based on Presentation Sample in Patients with Symptoms Suggestive of Acute Coronary Syndrome
Authors: Fred S Apple, Stephen W Smith, Lesly A Pearce, MaryAnn M Murakami
Journal: Circulation (2007)

OBJECTIVES: To determine if multiple biomarkers representative of numerous pathophysiologic pathways increase diagnostic accuracy for early detection of myocardial infarction (MI) in patients presenting with symptoms of acute coronary syndrome (ACS). BACKGROUND: Cardiac troponin has been accepted as the preferred biomarker for detecting myocardial injury and acute myocardial infarction. METHODS: Seven biomarkers (myeloperoxidase (MPO), soluble CD40 ligand (CD40L), placental growth factor (PIGF), metalloproteinase-9 (MMP-9), high sensitive C-reactive protein (hsCRP), cardiac troponin I (cTnI), N-terminal pro-B-type natriuretic peptide (NT-proBNP)) were measured on admission plasma specimens and estimated glomerular filtration rate (eGFR) calculated in 457 patients presenting with symptoms suggestive of ACS. Median time from symptom onset to presentation was 3.1 hours. Twenty-five (5.4%) patients were diagnosed with acute MI (ICD 410.×1 code). Clinical sensitivities and specificities of each biomarker for AMI were determined based on 99 th percentile reference values. Forward and backward stepwise logistic regression modeling techniques were used to identify biomarkers independently predictive of AMI. RESULTS: Clinical sensitivity of the biomarkers ranged from 20% to 96% with specificity ranging from 19% to 89%. Highest clinical sensitivity was MMP-9 but specificity was only 19%. cTnI demonstrated a clinical sensitivity of 72% and specificity of 89% with false negatives occurring in 7 patients and false positives in 49. In multivariate models, cTnI (p &lt; 0.001) and either hsCRP (p = 0.009) or MMP-9 (p = 0.03) and cTnI were independently predictive of AMI. hsCRP or MMP-9 increased specificity to 95% or 94% respectively but reduced sensitivity to 56% and 68% respectively relative to cTnI alone. CONCLUSION: Our findings support utilization of cTnI alone, rather than a multi-biomarker approach, when using an analytically robust assay based on the 99 th percentile reference value decision cutoff, as the most clinically accurate biomarker for the early diagnosis of AMI.
Abstract 5564: Circulating Endothelial Progenitor Cells Co-Expressing an Osteobastic Phenotype Are Increased in Patients With Severe Calcific Aortic Valve Stenosis
Authors: Mario Goessl, Ulrike I Moedder, Lilach O Lerman, Maurice E Sarano, Sundeep Khosla, Amir Lerman
Journal: Circulation (2009)

Objective To test the hypothesis that the numbers of circulating endothelial progenitor cells (EPC) co-expressing an osteogenic phenotype (EPC-OC) are increased in patients with clinically severe calcific aortic valve stenosis (AoC). Background AoC is one of the most common valvular heart diseases. Recent studies have shifted the old paradigm of AoC being a passive, degenerative process to an active biological process associated with an osteoblast-like phenotype. We have recently identified circulating EPC-OC which are significantly increased in patients with severe coronary artery disease (CAD). Methods and Results Of 38 patients, 14 underwent aortic valve replacement due to AoC with only mild angiographic CAD. Patients with normal aortic valves and coronary arteries (n=12) or severe CAD without aortic valve disease (n=12) served as controls (Table ). Peripheral blood mononuclear cells were analyzed using flow cytometry following staining for EPC markers (CD133, CD34, KDR) and the osteoblastic marker, osteocalcin (OC). Patients with AoC had significantly higher fractions of OC co-expression on EPC of different maturity than normal patients, similar to patients with CAD (Figure ). Conclusions Circulating EPC co-expressing an osteoblastic phenotype are increased and may potentially play a role in the active process of aortic valve calcification. Table. Clinical Data.
Abstract 16137: Chronic Baroreflex Activation Reduces Sympathetic Tone and Improves Clinical Outcomes in Reduced-Ejection Fraction Heart Failure
Authors: Edoardo Gronda, Gino Seravalle, Gianmaria Brambilla, Giuseppe Costantino, Tiziana Staine, Andrea Moneta, Andrea Casini, Elvia Capritti, Adel Alsheraei, Eric Lovett, Guido Grassi
Journal: Circulation (2013)

Introduction:  Heart failure mortality rate rises with increasing levels of sympathetic tone. Hyperadrenergic state directly mediates HF symptoms through vaso-/veno-constriction and fluid retention. Baroreflex activation therapy (BAT) reduces plasma norepinephrine and mortality while improving cardiovascular function in animal models of HF.   Hypothesis:  To determine if BAT, as administered by the Barostim  neo  system, improves clinical presentation and outcomes of patients with reduced-ejection fraction HF (HFrEF).   Methods:  HFrEF patients with the following characteristics were eligible to enroll in an open-label feasibility study: NYHA Class III, LVEF ≤ 40%, optimized medical therapy stable ≥ 4 weeks, 6-minute walk distance 150-450 m and no active treatment with cardiac resynchronization. Therapeutic effect was measured by hospitalization rate and surrogate variables including muscle sympathetic nerve activity (MSNA), walk distance, NYHA Class and the Minnesota living with HF questionnaire.   Results:  Eleven patients (10 Caucasian, 3 female) were implanted. MSNA, NYHA Class, quality of life, and hall walk distance contemporaneously improved (table). Medical therapy burden declined. Blood pressure, renal function and weight were stable. Of 9 patients who completed 6 months of follow-up, cardiovascular hospitalizations were reduced by 75% compared to the 6 months prior to implant (from 8 to 2), while average duration of hospitalization decreased 59% (from 9.75 to 4 days).   Conclusions:  BAT reduces hospitalization and improves clinical presentation in HFrEF. Concomitant reduction of sympathetic tone suggests a causal association. Larger prospective trials should verify this relationship and examine the impact of BAT on other key outcomes. Randomized trials of BAT in HFrEF are ongoing in North America and Europe.
Carotid Artery Revascularization in High-Surgical-Risk Patients Using the Carotid WALLSTENT and FilterWire EX/EZ
Authors: Sriram S. Iyer, Christopher J. White, L. Nelson Hopkins, Barry T. Katzen, Robert Safian, Mark H. Wholey, William A. Gray, Rocco Ciocca, William B. Bachinsky, Gary Ansel, James D. Joye, Mary E. Russell
Journal: Journal of the American College of Cardiology (2008)
Association of Annular Calcification and Aortic Valve Sclerosis With Brain Findings on Magnetic Resonance Imaging in Community Dwelling Older Adults
Authors: Carlos J. Rodriguez, Traci M. Bartz, W.T. Longstreth, Jorge R. Kizer, Eddy Barasch, Donald M. Lloyd-Jones, John S. Gottdiener
Journal: Journal of the American College of Cardiology (2011)
Use of the Research Diagnostic Criteria and the Schedule for Affective Disorders and Schizophrenia to study affective disorders
Authors: Jean Endicott, Robert L. Spitzer
Journal: American Journal of Psychiatry (1979)

In a pilot study of 150 manic or depressive patients, the authors used the Research Diagnostic Criteria (RDC) and the Schedule for Affective Disorders and schizophrenia (SADS) to perform preliminary analysis of symptom pictures of the index episode of different diagnostic groups, joint diagnostic classification of the different subtypes of major depressive disorder, and differential outcome by diagnostic groups. The results suggest that schizophrenic symptoms in affective disorders do have diagnostic and prognostic significance, that the term "psychotic depression" should be limited to impaired reality testing without reference to degree of incapacitation, that situational-nonsituational and endogenous-nonendogenous classifications are separate depressive subtypes, and that it may not be true that patients with endogenous major depressive disorder have a better prognosis than patients with nonendogenous depression.
Abstract 1292: Validation study on quantitative analysis method of interrelationships between immune cells and prostate epithelial and cancer cells
Authors: Gero Kramer, Lukas Kenner, Thomas Szekeres, Shahrokh Shariat, Sarah Schwarz
Journal: Cancer Research (2015)

Abstract Context based image analysis of immunohistochemically stained sections has become a topic after several studies have demonstrated that T-cell infiltration is important for survival and of prognostic value. Software algorithms for CD3 detection, epithelial gland detection and location analysis were validated using CD3 stained prostate biopsies. Prostate biopsies (n = 96, 38 with and 58 without tumor areas) were stained with anti-CD3-antibody (DAKO) and hematoxylin and were scanned. For validation, epithelial cell (EC) structures were manually annotated in StrataQuest 5.0 (TissueGnostics) using virtual biopsies. Automated enumeration of CD3 positive cells was controlled visually. For image processing, StrataQuests Easy Gland detection algorithm (SQ-GD) was used as provided. Briefly, hematoxylin shade was used for EC nuclei detection. EC structures were segmented using nuclei compactness and area. EC density was used to detect glands. To determine the relationships, distance transform from EC was added as virtual channel. EC proximity for CD3 distribution analysis were grouped into (i) within EC, (ii) 0-20 μm, (iii) 20-40 μm, (iv) 40-60 μm or (v) more from the EC border. Comparison of automated EC detection by SQ-GD with manually annotated EC showed a significant correlation of both methods (Pearson r = 0.74) although SQ-GD detects significantly more EC. The reason for that was that SQ-GD had to be adjusted so that missing EC areas were below 5%. CD3+/mm2 In ECCD3+/mm2 in 0 to 20μm EC proximityCD3+/mm2 in 20 to 40μm EC proximityCD3+/mm2 in 40 to 60μm EC proximityCD3+/mm2 in more than 60μm EC proximitymanualautomanualautomanualAutomanualautomanualautoTumor300±230390±213244±131148±126231±131191±138202±134168±151159±128128±184Non tumor416±586430±240270±209147±127243±168180±143240±143171±140172±128124±277Correlation0.8230.7380.7100.8020.815 In conclusion, SQ-GD algorithm detects EC in more than 95% of EC-glands and tumor areas. EC, tumor EC and CD3+ cells detection was highly sensitive to staining artifacts at biopsy borders and to tissue folding, both of which had to be manually excluded. Interestingly, we observed no differences between the biopsies negative for prostate cancer and the positive ones. It is noteworthy that the T-cell numbers gradually decrease in correlation with the distance to the epithelium suggesting a certain immunogenicity of EC. Note: This abstract was not presented at the meeting. Citation Format: Gero Kramer, Lukas Kenner, Thomas Szekeres, Shahrokh Shariat, Sarah Schwarz. Validation study on quantitative analysis method of interrelationships between immune cells and prostate epithelial and cancer cells. [abstract]. In: Proceedings of the 106th Annual Meeting of the American Association for Cancer Research; 2015 Apr 18-22; Philadelphia, PA. Philadelphia (PA): AACR; Cancer Res 2015;75(15 Suppl):Abstract nr 1292. doi:10.1158/1538-7445.AM2015-1292
MicroRNA Regulation of the Pathological Angiogenic Response
Authors: David Cheresh
Journal: Circulation (2011)

During development, pro- and anti-angiogenic factors orchestrate a complex, dynamic process to allow initial sprouting and invasion, subsequent pruning and remodeling, and finally maturation and survival of blood vessels. However, in pathological conditions such as cancer, diabetic retinopathy, macular degeneration or inflammation the same angiogenic signaling pathways are misregulated and exploited, typically resulting in poorly organized vessels with leaky and tortuous properties. In the last decade, a new class of small non-coding RNA molecules termed microRNAs (miRs) have emerged as key regulators of several cellular processes including angiogenesis. We recently profiled microRNAs that were regulated upon growth factor activation of human endothelial cells and identified miR-132 as a regulator of pathological neovascularization. We found that miR-132 was highly expressed in activated blood vessels, but was undetectable in normal endothelium. Ectopic expression of miR-132 in endothelial cells increased their proliferation and tube-forming capacity, whereas intraocular injection of an antagomir targeting miR-132, reduced postnatal retinal vascular development in mice. We identified p120RasGAP as a miR-132 target and showed that miR-132 and p120RasGAP are expressed reciprocally during pathological angiogenesis. Our observations in several in vitro and in vivo models suggest that miR-132 acts as an angiogenic switch by suppressing endothelial p120RasGAP expression, leading to Ras activation and the induction of neovascularization, whereas the application of anti–miR-132 inhibits neovascularization by maintaining vessels in the resting state. In contrast to miR-132, a highly upregulated miR during angiogenesis, we have identified miR-34 as one of the most downregulated microRNAs in response to growth factors. Conversely, miR-34a is highly upregulated during endothelial stress responses. Our observations suggest that miR-34a functions as an ‘apoptomiR’ mediating endothelial cell death during stress by regulating the Notch pathway. Taken together, our data suggests a broad regulatory network of pro and anti-angiogenic microRNAs that target defined pathways to co-ordinate vascular responses in development and disease.