VITAMIN D INTOXICATION DUE TO ERTRON: REPORT OF TWO CASES
Authors: C K DONEGAN, A L MESSER, E S ORGAIN
Journal: Annals of Internal Medicine (1949)

Case Reports1 February 1949VITAMIN D INTOXICATION DUE TO ERTRON: REPORT OF TWO CASESCHARLES K. DONEGAN, M.D., ADDISON L. MESSER, M.D., EDWARD S. ORGAIN, M.D., F.A.C.P.CHARLES K. DONEGAN, M.D.Search for more papers by this author, ADDISON L. MESSER, M.D.Search for more papers by this author, EDWARD S. ORGAIN, M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-30-2-429 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe deleterious effects of large doses of vitamin D, although well established, have not received sufficient emphasis in the therapy of those chronic conditions, notably arthritis, for which prolonged administration of the drug has been suggested.Danowski, Winkler, and Peters1reported two patients suffering from vitamin D intoxication, one of whom was taking vitamin D produced by the electrical activation of heat vaporized ergosterol. In both instances there was evidence of decreased renal function, and one patient exhibited soft tissue calcification. Freeman, Rhoads, and Yeager2described toxic symptoms due to hypervitaminosis D in two subjects taking Ertron. The important symptoms...Bibliography1. DANOWSKIWINKLERPETERS TSAWJP: Tissue calcification and renal failure produced by massive dose vitamin D therapy of arthritis, Ann. Int. Med., 1945, xxiii, 22-29. Google Scholar2. FREEMANRHOADSYEAGER SPSLB: Toxic manifestations associated with prolonged Ertron ingestion, Jr. Am. Med. Assoc., 1946, cxxx, 197-202. CrossrefGoogle Scholar3. BAUERFREYBERG JMRH: Vitamin D intoxication with metastatic calcification, Jr. Am. Med. Assoc., 1946, cxxx, 1208-1215. CrossrefGoogle Scholar4. KAUFMANBECKWISEMAN PRDRD: Vitamin D (Ertron) therapy in arthritis, Jr. Am. Med. Assoc., 1947, cxxxiv, 688-690. CrossrefGoogle Scholar5. MCCHESNEYMESSER EWF: The metabolism of calcium and phosphorus as influenced by various activated sterols, Am. Jr. Physiol., 1942, cxxxv, 577-586. CrossrefGoogle Scholar6. WATCHORN E: The absorption and excretion of calcium and phosphorus by rats receiving excessive doses of irradiated ergosterol, Biochem. Jr., 1930, xxiv, 631-640. CrossrefGoogle Scholar7. SHOHL AT: Physiology and pathology of vitamin D in The Vitamins, Am. Med. Assoc., Chapter xxiv, 459-474. Google Scholar8. GUTMANTYSONGUTMAN ABTLEB: Inorganic phosphorus, and phosphatase activity in hyper-parathyroidism, Paget's disease, multiple myeloma, and neoplastic disease of the bones, Arch. Int. Med., 1936, lvii, 379-413. CrossrefGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Durham, North Carolina*Received for publication August 28, 1947.From the Department of Medicine, Duke University School of Medicine and Duke Hospital, Durham, North Carolina. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byHypoparathyroidism with Hypophosphatemia A Clinical Paradox Due to Acquired Renal HyperphosphaturiaROBERT E. LORDON, JOHN J. MCPHAUL JR., DUNCAN A. MCINTOSHThe diagnostic spectrum of hypercalcemiaVITAMIN D INTOXICATION: REPORT OF TWO CASES TREATED WITH CORTISONE*JOHN V. VERNER JR., M.D., FRANK L. ENGEL, M.D., HARRY T. MCPHERSON, M.D.Some considerations pertaining to the proper use of supplementary vitaminsVitamin Supplementation in Health and Disease 1 February 1949Volume 30, Issue 2Page: 429-435KeywordsArthritisDrug administrationDrug therapyHospital medicineIntoxicationSoft tissuesVitamin D ePublished: 1 December 2008 Issue Published: 1 February 1949 PDF downloadLoading ...