tbuckley/cabot-search huggingface dataset:
Nodal Staging Score: A Tool to Assess Adequate Staging of Node-Negative Colon Cancer
Authors: Mithat Gönen, Deborah Schrag, Martin R. Weiser
Journal: Journal of Clinical Oncology (2009)

Adequate nodal staging of colon cancer has been defined as pathologic examination of at least 12 lymph nodes. We sought to refine this definition by quantifying the likelihood that a pathologically node-negative patient has, indeed, no positive nodes.Patients with stage I-III adenocarcinoma of the colon between 1994 and 2005 and had at least one lymph node pathologically examined were identified from the Surveillance, Epidemiology and End Results (SEER) database (n = 131,953). We estimated the sensitivity of the pathologic staging of locoregional spread using a beta-binomial model and developed the nodal staging score (NSS), which is the probability that a patient is correctly staged as node negative. NSS is a function of T stage and the number of examined nodes.The probability of missing a positive node that is in fact truly present is 29.7% if five nodes are examined, 20.0% if eight are examined, and drops to 13.6% for 12 nodes are examined. An NSS of 90% can be achieved by examining a single node for T1 and four nodes for T2 tumors. To maintain similar levels of NSS for T3, 13 nodes need to be examined and for T4 lesions, 21 nodes need to be examined. Graphical and tabular tools are provided to facilitate calculation of NSS and treatment decision making in practice.The minimum number of examined nodes for adequate staging depends on the T stage. The score we developed indicates the adequacy of nodal staging for patients with no positive nodes and can assist clinical decision making in the patient without nodal metastasis.
Multiple vitamin K-dependent coagulation zymogens promote adenovirus-mediated gene delivery to hepatocytes
Authors: Alan L. Parker, Simon N. Waddington, Campbell G. Nicol, Dmitry M. Shayakhmetov, Suzanne M. Buckley, Laura Denby, Geoffrey Kemball-Cook, Shaoheng Ni, Andre Lieber, John H. McVey, Stuart A. Nicklin, Andrew H. Baker
Journal: Blood (2006)
Echocardiographic Evaluation of Mitral Valve Structure and Function in Patients Followed for at Least 6 Months After Percutaneous Balloon Mitral Valvuloplasty
Authors: Vivian M. Abascal, Gerard T. Wilkins, Christopher Y. Choong, James D. Thomas, Igor F. Palacios, Peter C. Block, Arthur E. Weyman
Journal: Journal of the American College of Cardiology (1988)
Detailed clinical and angiographic analysis of transluminal extraction coronary atherectomy for complex lesions in native coronary arteries
Authors: Robert D. Safian, Melissa A. May, Anne Lichtenberg, Theodore L. Schreiber, Gregory Pavlides, Thomas B. Meany, Cindy L. Grines, William W. O'Neill
Journal: Journal of the American College of Cardiology (1995)
Points: Diagnosing the devastating
Authors: J M S Pearce
Journal: BMJ (1985)

reiterated my comment' on the treatment of cysticercosis with metriphonate and by means of radioimmunotherapy.Some other advances should be mentioned.In addition to praziquantel2-4 the anthelmninthic flubendazole has recently been used in the management of neurocysticercosis, with apparent success.5 Injection of quinine sulphate in distilled water into subcutaneous cysticerci has also been reported to destroy the bladderworms, thus obviating the need for their surgical excision.6
The Bell Tolls for a Constitutional Right to Physician-Assisted Suicide
Authors: George J. Annas
Journal: New England Journal of Medicine (1997)

For Whom the Bell Tolls, Ernest Hemingway's novel about the Spanish Civil War, ends with its American hero, Robert Jordan, mortally wounded and trying to decide whether to commit suicide with a machine gun or risk capture by trying to retain consciousness long enough to cover the retreat of his comrades. Confronting his impending death, Jordan thinks, “Dying is only bad when it takes a long time and hurts so much that it humiliates you.” Hemingway, one of the most American of American writers, committed suicide with a shotgun. Most suicides in the United States are committed with guns, . . .
Toxic Shock Syndrome and Estrogen Therapy
Authors: Philip L. Hooper
Journal: Annals of Internal Medicine (1989)

Letters and Corrections1 August 1989Toxic Shock Syndrome and Estrogen TherapyPhilip L. Hooper, MDPhilip L. Hooper, MDAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-111-3-263_2 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the Editor: Estrogen administration may play a role in the treatment of the toxic shock syndrome. I recently treated a woman with the toxic shock syndrome who did not respond to conventional therapy until her menstrual period was stopped with an injection of estrogen.A 34 year-old white woman presented with a 3-day history of myalgias, diarrhea, nausea, vomiting, and weakness. Her menstrual period had started 4 days before admission; she used a hyperabsorbent tampon and changed it every 8 hours. Her blood pressure was 60/0 and temperature was 39.5 0C. She had diffuse lower abdominal pain, tender cervix...Reference1. Feldman D. Evidence for the presence of steroid hormone receptors in fungi. In: Ringold G, ed. Steroid Hormone Action. New York: Alan R. Liss; 1988:169-76. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByCOVID-19 and heme oxygenase: novel insight into the disease and potential therapiesMenstrual toxic shock syndrome: case report and systematic review of the literature 1 August 1989Volume 111, Issue 3Page: 263-264KeywordsAbdominal painBlood pressureCervixDiarrheaEstrogensMyalgiaNauseaTemperatureToxic shock syndromeVomiting Issue Published: 1 August 1989 PDF DownloadLoading ...
TRAINING IN PSYCHOTHERAPY: THE USE OF MARRIAGE COUNSELING IN A UNIVERSITY TEACHING CLINIC
Authors: KENNETH E. APPEL, HILDA M. GOODWIN, HOWARD P. WOOD, EDWARD L. ASKREN
Journal: American Journal of Psychiatry (1961)

From the example it is seen that favorable therapeutic results took place without going into multiple details concerning orality and intensive personality analysis. To illustrate these techniques as they were used in a marriage counseling case, the significant details of a serious interpersonal conflict precipitated when the husband rejected his obese wife, have been presented. Both partners were seen individually and jointly by one therapist. The therapist focused on the day-to-day experience, eliciting the patient's feelings about reality situations which involved relationships to each other, parents and in-laws. Interpretations were kept to a minimum and were expressed simply, without technical terms. Ego strengths were supported. Ventilation of hostility was kept within tolerable limits. Solutions to difficulties evolved without going into genetics, details of personality structure, or the analysis of oral eroticism involved in obesity. The frame of reference was generally confined to present reality only occasionally moving into the past. The level of communication was interpersonal with occasional intrapersonal accents. The downward causal "spirals" of hostility, alienation, guilt and inadequacy were replaced with upward "spirals" of acceptance, increasing confidence, self-assertion and self-esteem through the corrective emotional experience with the therapist. This presentation does not imply that detailed microscopic analysis and intensive psychotherapy should not be employed in some cases and the psychiatric residents familiarized with them. Psychotherapy is an inadequately conceptualized subject. It is difficult to teach. Learning should involve a variety of techniques. Residents need experience in experimental enrichment as well as in conventional patterns of psychotherapy. To answer partially this need, training for residents has been provided in the Marriage Counseling Clinic of the Division of Family Study of the University of Pennsylvania.
Cathepsin L is required for endothelial progenitor cell–induced neovascularization
Authors: Carmen Urbich, Christopher Heeschen, Alexandra Aicher, Ken-ichiro Sasaki, Thomas Bruhl, Mohammad R Farhadi, Peter Vajkoczy, Wolf K Hofmann, Christoph Peters, Len A Pennacchio, Nasreddin D Abolmaali, Emmanouil Chavakis, Thomas Reinheckel, Andreas M Zeiher, Stefanie Dimmeler
Journal: Nature Medicine (2005)
Erratum: Corrigendum: Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis
Authors: Benjamin F Voight, Laura J Scott, Valgerdur Steinthorsdottir, Andrew P Morris, Christian Dina, Ryan P Welch, Eleftheria Zeggini, Cornelia Huth, Yurii S Aulchenko, Gudmar Thorleifsson, Laura J McCulloch, Teresa Ferreira, Harald Grallert, Najaf Amin, Guanming Wu, Cristen J Willer, Soumya Raychaudhuri, Steve A McCarroll, Claudia Langenberg, Oliver M Hofmann, Josée Dupuis, Lu Qi, Ayellet V Segrè, Mandy van Hoek, Pau Navarro, Kristin Ardlie, Beverley Balkau, Rafn Benediktsson, Amanda J Bennett, Roza Blagieva, Eric Boerwinkle, Lori L Bonnycastle, Kristina Bengtsson Boström, Bert Bravenboer, Suzannah Bumpstead, Noisël P Burtt, Guillaume Charpentier, Peter S Chines, Marilyn Cornelis, David J Couper, Gabe Crawford, Alex S F Doney, Katherine S Elliott, Amanda L Elliott, Michael R Erdos, Caroline S Fox, Christopher S Franklin, Martha Ganser, Christian Gieger, Niels Grarup, Todd Green, Simon Griffin, Christopher J Groves, Candace Guiducci, Samy Hadjadj, Neelam Hassanali, Christian Herder, Bo Isomaa, Anne U Jackson, Paul R V Johnson, Torben Jørgensen, Wen H L Kao, Norman Klopp, Augustine Kong, Peter Kraft, Johanna Kuusisto, Torsten Lauritzen, Man Li, Aloysius Lieverse, Cecilia M Lindgren, Valeriya Lyssenko, Michel Marre, Thomas Meitinger, Kristian Midthjell, Mario A Morken, Narisu Narisu, Peter Nilsson, Katharine R Owen, Felicity Payne, John R B Perry, Ann-Kristin Petersen, Carl Platou, Christine Proença, Inga Prokopenko, Wolfgang Rathmann, N William Rayner, Neil R Robertson, Ghislain Rocheleau, Michael Roden, Michael J Sampson, Richa Saxena, Beverley M Shields, Peter Shrader, Gunnar Sigurdsson, Thomas Sparsø, Klaus Strassburger, Heather M Stringham, Qi Sun, Amy J Swift, Barbara Thorand, Jean Tichet, Tiinamaija Tuomi, Rob M van Dam, Timon W van Haeften, Thijs van Herpt, Jana V van Vliet-Ostaptchouk, G Bragi Walters, Michael N Weedon, Cisca Wijmenga, Jacqueline Witteman, Richard N Bergman, Stephane Cauchi, Francis S Collins, Anna L Gloyn, Ulf Gyllensten, Torben Hansen, Winston A Hide, Graham A Hitman, Albert Hofman, David J Hunter, Kristian Hveem, Markku Laakso, Karen L Mohlke, Andrew D Morris, Colin N A Palmer, Peter P Pramstaller, Igor Rudan, Eric Sijbrands, Lincoln D Stein, Jaakko Tuomilehto, Andre Uitterlinden, Mark Walker, Nicholas J Wareham, Richard M Watanabe, Gonçalo R Abecasis, Bernhard O Boehm, Harry Campbell, Mark J Daly, Andrew T Hattersley, Frank B Hu, James B Meigs, James S Pankow, Oluf Pedersen, H-Erich Wichmann, Inês Barroso, Jose C Florez, Timothy M Frayling, Leif Groop, Rob Sladek, Unnur Thorsteinsdottir, James F Wilson, Thomas Illig, Philippe Froguel, Cornelia M van Duijn, Kari Stefansson, David Altshuler, Michael Boehnke, Mark I McCarthy
Journal: Nature Genetics (2011)
P1-02-09: Epigenetics-Regulated microRNAs Related with Epithelial-Mesenchymal Transition of Breast Cancer Cells.
Authors: F Sato, T Ito, S Tsuchiya, N Kawaguchi-Sakita, K Shimizu, G Tsujimoto, M Toi
Journal: Cancer Research (2011)

Abstract Background: Epithelial-mesenchymal transition (EMT) is a program in which biological cells change morphologically and functionally from an epithelial phenotype to a mesenchymal phenotype. The EMT is involved in the process of cancer metastasis. On the other hand, accumulated evidence showed epigenetics and microRNA plays important roles in breast cancer. However, to date, biological networks between epigenetics and microRNAs regarding EMT remains largely unclear. Thus, the aim of this study is to identify epigenetics-regulated microRNAs related with EMT of breast cancer. Materials / Methods and Results: MicroRNA expression profiles of 11 breast cancer cell lines (8 epithelial-phenotype (E-type) cells and 3 mesenchymal-phenotype (M-type) cells) were obtained by microarray method. Unsupervised clustering analysis showed that E- and M-type breast cancer cells had different microRNA expression profiles. On the other hand, we obtained a genomewide methylation status of these breast cancer cell lines by a MeDIP-seq method. An integrated in silico analysis identified microRNAs which microRNA and DNA methylation were inversely correlated. All of miR-200b/a/429 cluster members were listed in top5 differentially expressed miRs between E-and M-type cells, and also in top 5 epigenetics-regulated microRNAs. In the further study, we focused upon the miR-200b/a/429 cluster. A COBRA assay revealed that promoter regions of miR-200b/a/429 cluster in M-type breast cancer cells were more frequently methylated than that in E-type cells (65.1% vs 6.8%, p&amp;lt;0.0001, respectively). The methylation levels were inversely associated with miR-200b/a/429 cluster expression (Taqman assay, p&amp;lt;0.01). In addition, demethylating treatment using 5-aza-dC unmasked miR-200b/a/429 expression in M-typed breast cancer cell lines. Taken together, the finding indicated that the expression of miR-200b/a/429 cluster is epigenetically regulated. Next, we investigated an effect of the miR-200b/a/429 cluster upon cell motility as a function of the EMT. A transfection of exogenous miR-200b/429 inhibited 24% of cell migration ability (Transwell assay). Utilizing microRNA target prediction algorithm, we identified fibronectin as a target gene of miR-200b/429. Utilizing several prediction algorithms for microRNA target genes, we identified fibronectin as a target gene of miR-200b/429. A luciferase-based reporter assay demonstrated that miR-200b/429 were directly associated with fibronectin-3'UTR and repressed 21% (p&amp;lt;0.0001) of the reporter gene expression post-transcriptionally. Conclusion: The promoter hypermethylation of miR-200b cluster is associated with epithelial-mesenchymal transition, and stimulates cell motility by upregulating fibronectin expression in mesenchymal-phenotype breast cancer cells. Citation Information: Cancer Res 2011;71(24 Suppl):Abstract nr P1-02-09.
Pericardial-Fluid Complement
Authors: DON GOLDENBERG
Journal: Annals of Internal Medicine (1973)

Comments and Corrections1 May 1973Pericardial-Fluid ComplementDON GOLDENBERG, M.D.DON GOLDENBERG, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-78-5-786_1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: The article "Rheumatoid Pericarditis" in the December 1972 issue (pp. 837-844) mentions that hemolytic complement (CH50) was measured simultaneously in serum and pericardial fluid of two patients, with CH50 levels in the pericardial fluid being 22% and 33%, respectively, of the serum levels. The analogy between corresponding values of synovial fluid CH50 and pericardial fluid CH50 with simultaneous serum CH50 was made, and it was stated that CH50 level may be of diagnostic aid in rheumatoid pericardial fluid as well as synovial fluid.Recently we evaluated the pericardial fluid from a 24-year-old women who met the ARA...References1. COHEN A, REYNOLDS W, and FRANKLIN E: Preliminary criteria for the classification of systemic lupus erythematosus. Bull Rheum Dis 21:643-648, 1971 Google Scholar2. GOLDENBERG D, LEFF G, and GRAYZEL A: Pericardial tamponade as a presenting feature of systemic lupus erythematosus. Unpublished Google Scholar3. PINCUS T, SCHUR P, and ROSE J: Measurement of serum DNA-binding activity in systemic lupus erythematosus. N Engl J Med 281:701-705, 1969 CrossrefMedlineGoogle Scholar4. HUNDER G, MCDUFFIE F, and HEPPER N: Pleural fluid complement in systemic lupus erythematosus and rheumatoid arthritis. Ann Intern Med 76:357-363, 1972 LinkGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: DON GOLDENBERG, M.D.Affiliations: Department of Rheumatology Boston University Hospital Boston, Massachusetts PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byChance, genetics, and the heterogeneity of disease and pathogenesis in systemic lupus erythematosusQuantitation of Complement Proteins in Rheumatic DiseaseComplement in Pericardial Fluid of Lupus Erythematosus Studies in Two PatientsGENE G. HUNDER, M.D., F.A.C.P., BERNARD JAMES MULLEN, M.D., FREDERIC C. MCDUFFIE, M.D., F.A.C.P. 1 May 1973Volume 78, Issue 5Page: 786-786KeywordsSynovial fluid ePublished: 1 December 2008 Issue Published: 1 May 1973 PDF downloadLoading ...
Grand Challenges: Integrating Mental Health Care into the Non-Communicable Disease Agenda
Authors: Victoria K. Ngo, Adolfo Rubinstein, Vijay Ganju, Pamela Kanellis, Nasser Loza, Cristina Rabadan-Diehl, Abdallah S. Daar
Journal: PLoS Medicine (2013)

In the third article of a five-part series providing a global perspective on integrating mental health, Victoria Ngo and colleagues discuss the benefits and requirements of collaborative care models, where non-communicable disease and mental health care are integrated and provided in the primary care setting. Please see later in the article for the Editors' Summary
Impact of Diabetes on the Risk Stratification Using Stress Single-Photon Emission Computed Tomography Myocardial Perfusion Imaging in Patients With Symptoms Suggestive of Coronary Artery Disease
Authors: Satyendra Giri, Leslee J. Shaw, Dakshina R. Murthy, Mark I. Travin, D. Douglas Miller, Rory Hachamovitch, Salvadore Borges-Neto, Daniel S. Berman, David D. Waters, Gary V. Heller
Journal: Circulation (2002)

Background — Coronary artery disease can develop prematurely and is the leading cause of death among diabetics, making noninvasive risk stratification desirable. Methods and Results — Patients with symptoms of coronary artery disease who were undergoing stress myocardial perfusion imaging (MPI) from 5 centers were prospectively followed (2.5±1.5 years) for the subsequent occurrence of cardiac death, myocardial infarction (MI), and revascularization. Stress MPI results were categorized as normal or abnormal (fixed or ischemic defects and 1, 2, or 3 vessel distribution). Of 4755 patients, 929 (19.5%) were diabetic. Patients with diabetes, despite an increased revascularization rate, had 80 cardiac events (8.6%; 39 deaths and 41 MIs) compared with 172 cardiac events (4.5%; 69 deaths and 103 MIs) in the nondiabetic cohort ( P &lt;0.0001). Abnormal stress MPI was an independent predictor of cardiac death and MI in both populations. Diabetics with ischemic defects had an increased number of cardiac events ( P &lt;0.001), with the highest MI rates (17.1%) observed with 3-vessel ischemia. Similarly, a multivessel fixed defect was associated with the highest rate of cardiac death (13.6%) among diabetics. The unadjusted cardiac survival rate was lower for diabetic patients (91% versus 97%, P &lt;0.001), but it became comparable once adjusted for the pretest clinical risk and stress MPI results. In multivariable Cox analysis, both ischemic and fixed MPI defects independently predicted cardiac death alone or cardiac death/MI. Diabetic women had the worst outcome for any given extent of myocardial ischemia. Conclusions — In this large cohort of diabetics undergoing stress MPI, the presence and the extent of abnormal stress MPI independently predicted subsequent cardiac events. Using stress MPI in conjunction with clinical information can provide risk stratification of diabetic patients.
Flu costs the US $90bn a year, report shows
Authors: Roger Dobson
Journal: BMJ (2007)

Wiltshire police investigating unspecified allegations against a paediatrician at Southampton General Hospital are seeking expert medical evidence outside the UK.The case concerns a paediatrician who was involved in the care of a child whose mother was later charged with murder.Marianne Williams, then 22, was charged in 2004 with the murder of her 15 month old son, Joshua Taylor, whom she was alleged to have poisoned with salt.She was found not guilty in October last year after a six week trial at Winchester Crown Court.Wiltshire police officers are also under investigation for their role in the case.The Independent Police Complaints Commission said that it was "midway through" an investigation into a complaint about the conduct of the criminal investigation.Six officers had been served with official notice of the inquiry, although "this in no way implies guilt or wrongdoing on the part of any officer," the commission said.Detective Superintendent James Vaughan, the officer leading the Wiltshire force's inquiry into the allegations against the doctor, confirmed that Wiltshire Police would not be seeking medical advice in the case from any British doctors-a claim posted on the website forum Mothers Against Munchausen Allegations."In order to maintain the confidence of Joshua's family, and to identify an independent specialist who has had no connection with this or any other similar sets of circumstances in the United Kingdom, it has been necessary to seek assistance from overseas," Detective Superintendent Vaughan said.This was, he insisted, "not a reflection on the Wiltshire police's confidence in the United Kingdom experts."However, the Royal College of Paediatrics and Child Health said it was "confident that we have eminent experts in the UK who can offer an independent and authoritative opinion." Police look abroad for salt case expertUK NEWS Remedy UK loses court case, p1134
Follicular dendritic cell sarcoma mimicking diffuse large cell lymphoma: A case report
Authors: Rafael Fonseca, Ayalew Tefferi, John G. Strickler
Journal: American Journal of Hematology (1997)

Follicular dendritic cell sarcomas (FDCSs) are rare tumors arising from follicular dendritic cells in lymphoid tissue. Fewer than 20 cases have been described in the English-language literature. We describe the second case of an FDCS with primary liver involvement. The initial diagnosis was lymphoma, and appropriate treatment was prescribed. After the initial treatment failed, additional biopsy samples were obtained. Standard pathologic analysis and immunophenotyping for a panel of monoclonal antibodies were performed on formalin-fixed paraffin-embedded tissue and frozen sections. The pathologic findings were consistent with FDCS, and the specimens showed some of the characteristic pathologic features suggestive of this tumor, including multinucleation and a spindle pleomorphic morphology. The tumor cells were positive for S-100 protein, CD45, CD14, and vimentin. Because of its morphological characteristics, FDCS can be confused with other neoplastic entities, such as lymphomas and other solid tumors. Am. J. Hematol. 55:148–155, 1997. © 1997 Wiley-Liss, Inc.