tbuckley/cabot-search huggingface dataset:
Mortality probability in victims of fire trauma: revised equation to include inhalation injury.
Authors: C J Clark, W H Reid, W H Gilmour, D Campbell
Journal: BMJ (1986)

There are no clear guidelines on the early diagnosis of injury due to inhalation of smoke. A clinical scoring system in the form of a previously prepared questionnaire may be used in the accident and emergency department by staff who are inexperienced in the management of inhalation injury. By quantifying injury due to smoke inhalation, its contribution to mortality in a large group of fire victims was established and a revised mortality probability equation derived using age, percentage surface area of the burn, and extent of inhalation injury. This mortality probability equation may be used to divide patients into risk categories for early intensive care management and allows the comparison of mortality data between accident and emergency units receiving varying numbers of patients with injuries due to burns and smoke inhalation.
Lansley says he "can entertain any amount of change in the bill"
Authors: S. Welsh
Journal: BMJ (2011)

The secretary of state for health Andrew Lansley has said he “can entertain any amount of change in the bill if it is in the best interests of patients.”

Speaking at an NHS Leadership and Management Summit at the King’s Fund on 18 May Mr Lansley said he was open to ideas to make changes to the Health and Social Care Bill, currently “paused” in its legislative path for the government to gather opinions on how the bill should be amended.

Mr Lansley was responding to a report by the King’s Fund, which urges the government to …
Where there's will, there's a way
Authors: R. Lede
Journal: BMJ (1999)

<h3>Abstract</h3> Acute myeloid leukemia (AML) is a heterogeneous malignancy of the bone marrow associated with poor outcomes and limited treatment options available to patients. Recent developments have demonstrated that patient stratification based on disease classification (e.g. somatic mutations) allows for selective treatment regimens and greatly improved outcomes. AML patients can also be stratified based upon the heterogeneous immunophenotype of surface antigen expression on leukemic blasts and stem cells. Here we present data identifying a sub-population of AML patients showing expression of both CD33 and CD7 on their tumour cells, using mass cytometry. This combination of antigens is disease-specific, and is not expressed on healthy haematopoietic cells in patients. We developed a bispecific antibody–drug conjugate (ADC) targeting both CD7 and CD33 and demonstrate that these bispecific ADCs are cytotoxic to AML cells <i>in vitro.</i> Importantly, the anti-CD33/CD7 bispecific ADCs are more selective than single-antigen targeting ADCs and safely discriminate tumour from healthy cells (either myeloid or lymphoid). These anti-CD33/CD7 bispecific ADCs are well tolerated and selectively target AML cells in pre-clinical <i>in vivo</i> studies in mice. This study presents the first proof-of-principle for targeting specific and unique combinations of surface antigens on tumour cells with potential to overcome observed toxicities with current ADCs.
Can the new “electronic highway” for the NHS have a smooth launch?
Authors: Geoff Watts
Journal: BMJ (2004)

The NHS in England is getting serious about information technology. It has to. Size, organisational complexity, and burgeoning knowledge are all driving in the same direction: a new “electronic highway” linking all parts of the NHS. The new system will provide “seamless care for patients through GPs, hospitals, and community health services.” That, at any rate, is the hope.

Typically for Britain, many innovations in NHS computing have been the brain children of talented enthusiasts. The GP, the registrar, or the manager who could see a better way of referring patients, retrieving their records, or juggling available bed space have all made their mark. But the day of the amateur geek, however inspired, is over. …
Successful removal of pathogenic autoantibodies in pemphigus by immunoadsorption with a tryptophan-linked polyvinylalcohol adsorber
Authors: M. LUftl, A. Stauber, A. Mainka, R. Klingel, G. Schuler, M. Hertl
Journal: British Journal of Dermatology (2003)

Journal Article Successful removal of pathogenic autoantibodies in pemphigus by immunoadsorption with a tryptophan‐linked polyvinylalcohol adsorber Get access M. LÜftl, M. LÜftl Department of Dermatology, University Hospital of Erlangen, Hartmannstr. 14, D‐91052 Erlangen, Germany Search for other works by this author on: Oxford Academic Google Scholar A. Stauber, A. Stauber Department of Dermatology, University Hospital of Erlangen, Hartmannstr. 14, D‐91052 Erlangen, Germany Search for other works by this author on: Oxford Academic Google Scholar A. Mainka, A. Mainka Department of Dermatology, University Hospital of Erlangen, Hartmannstr. 14, D‐91052 Erlangen, Germany Search for other works by this author on: Oxford Academic Google Scholar R. Klingel, R. Klingel Apheresis Research Institute, Cologne, Germany Search for other works by this author on: Oxford Academic Google Scholar G. Schuler, G. Schuler Department of Dermatology, University Hospital of Erlangen, Hartmannstr. 14, D‐91052 Erlangen, Germany Search for other works by this author on: Oxford Academic Google Scholar M. Hertl M. Hertl Department of Dermatology, University Hospital of Erlangen, Hartmannstr. 14, D‐91052 Erlangen, Germany M.Hertl, M.D. E‐mail: michael.hertl@derma.imed.uni‐erlangen.de Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 149, Issue 3, 1 September 2003, Pages 598–605, https://doi.org/10.1046/j.1365-2133.2003.05513.x Published: 01 September 2003 Article history Accepted: 01 January 2003 Published: 01 September 2003
Radiofrequency ablation for the endoscopic eradication of esophageal squamous high grade intraepithelial neoplasia and mucosal squamous cell carcinoma
Authors: F. van Vilsteren, L. Alvarez Herrero, R. Pouw, F. ten Kate, M. Visser, C. Seldenrijk, M. van Berge Henegouwen, B. Weusten, J. Bergman
Journal: Endoscopy (2011)

See also: Commentaire de travail de F. G. I. van Vilsteren et al., pp. 282Endoscopy 2011; 43(04): 462-462DOI: 10.1055/s-0031-1291792
Myocardial Blood Flow and Oxygen Uptake During Acute Red Cell Volume Increments
Authors: Timothy J. Regan, Martin J. Frank, Patrick H. Lehan, James G. Galante, Harper K. Hellems
Journal: Circulation Research (1963)

The role of red cell mass in the regulation of coronary blood flow and myocardial oxygen consumption has been examined after acute transfusion of sedimented red cells. Patients with substantial blood-loss anemia had a lower than normal left ventricular oxygen uptake, despite a high myocardial blood flow at rest. A 50% rise of hematocrit reduced coronary flow markedly. Although systemic arterial pressure, cardiac output, and left heart work rose, myocardial oxygen consumption was unchanged. Red cell transfusion of normovolemic dogs resulted in a decrease of both myocardial flow and oxygen uptake associated with an elevation of time-tension index and left ventricular work, accelerated isometric contraction and prolonged systole. There was no evidence of ischemia or change of left ventricular hemodynamic parameters that would account for the reduced myocardial blood flow and oxygen uptake. These findings, in the presence of an increased oxygen carrying capacity and extraction, would appear to be related principally to enhanced blood viscosity.
Nasal oxygen during endoscopy.
Authors: J Rosenberg
Journal: Gut (1993)

The role of IL-4, a key Th2 cytokine, in promoting or inhibiting active Heymann nephritis (HN) was examined. HN is induced by immunization with Fx1A in CFA, and proteinuria in HN is associated with subepithelial IgG and C3 deposition and infiltration of CD8<sup>+</sup> T-cytotoxic 1 (Tc1) cells and macrophages into glomeruli, as well as induction of Abs to Crry. Treatment with rIL-4 from the time of Fx1A/CFA immunization stimulated an earlier IgG1 response to Fx1A, induced anti-Crry Abs, and up-regulated IL-4 mRNA in lymphoid tissue, but did not alter proteinuria. Treatment with MRCOx-81, an IL-4-blocking mAb, resulted in greater proteinuria, which suggests endogenous IL-4 regulated the autoimmune response. Delay of rIL-4 treatment until 4 wk post-Fx1A/CFA immunization and just before the onset of proteinuria prevented the development of proteinuria and reduced Tc1 cell infiltrate in glomeruli. Delayed treatment with IL-4 had no effect on titer or isotype of Abs to Fx1A or on Ig, C3, and C9 accumulation in glomeruli. Treatment with rIL-13, a cytokine that alters macrophage function such as rIL-4, but has no direct effect on T or B cell function, reduced glomerular macrophage infiltrate, but did not prevent proteinuria or CD8<sup>+</sup> T cell infiltrate. Anti-Crry Abs were paradoxically only induced with rIL-4 therapy, not in HN controls with proteinuria. It was concluded that the rIL-4 effect was probably by inhibition of Tc1 cells, which normally mediate the glomerular injury that results in proteinuria.
Electrogram patterns predictive of successful catheter ablation of accessory pathways. Value of unipolar recording mode.
Authors: M Haïssaguerre, J F Dartigues, J F Warin, P Le Metayer, P Montserrat, R Salamon
Journal: Circulation (1991)

Transcatheter electrical ablation has been used in the treatment of arrhythmias, and most experience has been obtained by ablating the normal atrioventricular conduction system. Less information is available on ablation of atrioventricular accessory pathways.Catheter ablation of overt accessory pathways was attempted in 135 patients with 142 distinct pathways, including 21 right parietal or anteroseptal, 47 posteroseptal, and 74 left lateral pathways. We sought to identify the type and value of electrophysiological parameters associated with successful ablation outcome. For this purpose, the unipolar recording mode was used in addition to bipolar anterograde and retrograde parameters. With a mean follow-up of 16 +/- 6 (mean +/- SD) months, fulguration was successful in eliminating preexcitation in 129 patients (96%), including all seven with two distinct accessory pathways. The first ablation attempt was successful in 110 patients, and two or more attempts were performed in 25 patients. Bipolar electrograms associated with success of fulguration showed a shorter atrioventricular conduction time (40 +/- 13 versus 53 +/- 17 msec, p less than 0.0001) and an earlier main ventricular deflection relative to delta wave onset (-1.7 +/- 10 versus 5 +/- 7 msec, p less than 0.001) than electrograms associated with unsuccessful outcome. The only parameter dealing with retrograde conduction (i.e., ventriculoatrial conduction time during reciprocating tachycardia) was not predictive (86 +/- 17 versus 93 +/- 17 msec). Neither was the atrial to ventricular electrogram amplitude ratio. Two unipolar parameters were found to be predictive of successful outcome: 1) The three different patterns PQS, P-QS, P-rS of unipolar waves recorded at the annulus were associated with respective success rates of 97%, 78%, and 55% (p less than 0.001). 2) Intrinsic deflection timing occurred -4 +/- 8 and 6 +/- 7 msec relative to delta wave onset in successful attempts and in failures, respectively (p less than 0.001). Logistic regression analysis revealed a single independent factor predictive of success, the unipolar pattern (p = 0.03), with an odds ratio of 7:1 (PQS pattern versus P-rS pattern). In the group of 18 patients who underwent a first unsuccessful but second successful attempt, comparison of electrograms revealed no difference in the ventriculoatrial conduction time but a significant improvement in anterograde parameters and unipolar pattern distribution.Some distinctive electrogram patterns concerning anterograde conduction are associated with success of accessory pathway fulguration. The unfiltered unipolar recording mode (PQS pattern) contributes significantly to optimizing the accuracy of accessory pathway localization.
Inhibition of Tumor Necrosis Factor α for Refractory Asthma
Authors: Serpil C. Erzurum
Journal: New England Journal of Medicine (2006)

Tumor necrosis factor (TNF), originally discovered and named on the basis of its tumor regression activity, is an important cytokine that regulates the pathogenetic mechanisms of chronic inflammatory diseases.1,2 The translation of research findings to patient care resulted in the first successful cytokine-specific targeted therapies, the TNF inhibitors. Currently available inhibitors include the monoclonal antibodies against TNF-α, infliximab and adalimumab, and the soluble TNF receptor fused to human IgG, etanercept.1,2 Agents that block TNF-α suppress inflammation, slow disease progression, and in some cases, induce remission in patients with rheumatoid arthritis, ankylosing spondylitis, psoriasis, and Crohn's disease.2 In this . . .
PTEN Loss Does Not Predict for Response to RAD001 (Everolimus) in a Glioblastoma Orthotopic Xenograft Test Panel
Authors: Lin Yang, Michelle J. Clarke, Brett L. Carlson, Ann C. Mladek, Mark A. Schroeder, Paul Decker, Wenting Wu, Gaspar J. Kitange, Patrick T. Grogan, Jennie M. Goble, Joon Uhm, Evanthia Galanis, Caterina Giannini, Heidi A. Lane, C. David James, Jann N. Sarkaria
Journal: Clinical Cancer Research (2008)

Abstract Purpose: Hyperactivation of the phosphatidylinositol 3-kinase/Akt signaling through disruption of PTEN function is common in glioblastoma multiforme, and these genetic changes are predicted to enhance sensitivity to mammalian target of rapamycin (mTOR) inhibitors such as RAD001 (everolimus). Experimental Design: To test whether PTEN loss could be used as a predictive marker for mTOR inhibitor sensitivity, the response of 17 serially transplantable glioblastoma multiforme xenografts was evaluated in an orthotopic therapy evaluation model. Of these 17 xenograft lines, 7 have either genomic deletion or mutation of PTEN. Results: Consistent with activation of Akt signaling, there was a good correlation between loss of PTEN function and elevated levels of Akt phosphorylation. However, of the 7 lines with disrupted PTEN function, only 1 tumor line (GBM10) was significantly sensitive to RAD001 therapy (25% prolongation in median survival), whereas 1 of 10 xenograft lines with wild-type PTEN was significantly sensitive to RAD001 (GS22; 34% prolongation in survival). Relative to placebo, 5 days of RAD001 treatment was associated with a marked 66% reduction in the MIB1 proliferation index in the sensitive GBM10 line (deleted PTEN) compared with a 25% and 7% reduction in MIB1 labeling index in the insensitive GBM14 (mutant PTEN) and GBM15 (wild-type PTEN) lines, respectively. Consistent with a cytostatic antitumor effect, bioluminescent imaging of luciferase-transduced intracranial GBM10 xenografts showed slowed tumor growth without significant tumor regression during RAD001 therapy. Conclusion: These data suggest that loss of PTEN function is insufficient to adequately predict responsiveness to mTOR inhibitors in glioblastoma multiforme.
Life Expectancy After Response to Chemotherapy of Gastrointestinal Cancer.
Authors: Sherwyn E. Warren
Journal: Annals of Internal Medicine (1965)

s1 November 1965Life Expectancy After Response to Chemotherapy of Gastrointestinal Cancer.Sherwyn E. Warren, M.D., John Van Prohaska, M.D., Joseph B. Kirsner, M.D.Sherwyn E. Warren, M.D.Search for more papers by this author, John Van Prohaska, M.D.Search for more papers by this author, Joseph B. Kirsner, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-63-5-917_2 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe clinical course of 55 patients with metastatic adenocarcinoma of the gastrointestinal tract treated with FU or FUDR was evaluated. Of these, the neoplasm arose in the stomach in 18, colon in 17, and pancreas in 20. An attempt was made to assess length of survival in patients who achieved remission.Of the 18 patients with primary stomach carcinoma, 11 derived no objective benefit from chemotherapy, and in 3 preterminal patients, complications of chemotherapy contributed to their deaths. Seven patients responded to chemotherapy, as evidenced by significant (> 50%) decrease in tumor size, and clinical improvement. Of the seven patients,... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Chicago, Illinois PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByA one-stage synthesis of adenine from formamide and phosphorus oxychloride 1 November 1965Volume 63, Issue 5Page: 917-917KeywordsAdenocarcinomaCancer chemotherapyChemotherapyColonGastrointestinal cancersGastrointestinal tractLife expectancyPancreasStomach Issue Published: 1 November 1965 PDF DownloadLoading ...
Treatment of severe psoriasis with etretin (RO 10-1670)
Authors: A. LASSUS, J.-M. GEIGER, M. NYBLOM, T. VIRRANKOSKI, M. KAARTAMAA, L. INGERVO
Journal: British Journal of Dermatology (1987)

Eighty patients with severe psoriasis were treated in a double-blind fashion with either an initial dose of 10 mg, 25 mg or 50 mg of etretin daily or with placebo. Follow-up examinations were carried out monthly and the efficacy of treatment was evaluated by using the PASI score. Adverse effects of the treatment were recorded monthly; liver enzymes, cholesterol and triglycerides were measured. After 2 months of treatment the maintenance dose was reduced in some of the patients either because of complete remission or adverse effects. After 2 months treatment, groups receiving 25 mg/day and 50 mg/day showed significantly lower PASI scores than the placebo group. The 10 mg/day group showed a response intermediate between the 25 mg and 50 mg groups and the placebo group. Thus, the optimal initial dose seems to be approximately 25 mg/day and the maintenance dose somewhat lower. Six months after the start of treatment there were no significant differences between the four groups; the last follow-up examination took place during the summer and some of the patients probably experienced spontaneous improvement. Although clinical adverse effects were frequent in all groups, severe side effects, namely hair loss and paronychia, occurred frequently only among patients treated with an initial dose of 50 mg of etretin daily. The effect of treatment on liver enzymes, cholesterol and triglycerides was minimal.
Revised Staging: Is It Really Better, or Do We Not Know?
Authors: Iris D. Nagtegaal, Philip Quirke
Journal: Journal of Clinical Oncology (2010)

In TNM4, tumor deposits were not mentioned; depending on the pathologist and his or her interpretation of the rules of spread, this could be classified as either stage I or II.†Morphology suggests extramural vascular invasion, which did not affect T stage in TNM4.
Case 15-1973
Authors: Richard C. Cabot, Benjamin Castleman, Robert E. Scully, Betty U. McNeely, Gordon T. Moore, Gerald Nash
Journal: New England Journal of Medicine (1973)

Presentation of CaseA 24-year-old man was admitted to the hospital because of dyspnea.At the age of one year he underwent a right nephrectomy because of hydronephrosis associated with bilateral duplication of the collecting systems, with anomalous vessels. Repeated urinary-tract infections occurred and were treated with sulfonamides, and the renal function deteriorated progressively. Six years before admission hypertension was found. Three years later chronic hemodialysis was begun. Thirteen months before entry a left nephrectomy was performed because of hypertension with papilledema. Six months before admission he underwent transplantation of a cadaveric kidney. For several months thereafter prednisone and azathioprine . . .
Abnormal cervical smears: are we in for an epidemic?
Authors: M R Wolfendale, S King, M M Usherwood
Journal: BMJ (1983)

A retrospective study was conducted to examine the pattern of a disturbing increase in abnormal cervical smears in one health district. Past records over fifteen years (1965-79) were analysed to produce pick up rates according to age, screening state, severity of lesion, and area of residence. Main findings included an increased pick up rate in unscreened (5.8 to 12.9/1000 smears) and screened (0.9 to 3.6/1000 smears) women. The order of increase was proportionately much higher in women under 40 years. The only significant epidemiological variable in the catchment area was a substantial population increase, overweighted by the younger age groups. The principal conclusion of the study was that the increased pick up rates of abnormal cervical smears in the district reflected a true increase in the incidence of premalignant lesions of the cervix. Screening efforts aided by computerisation should be examined nationwide in order to reach high risk groups and thus try to prevent an increase in carcinoma of the cervix.
Hepatitis C Research Tool
Authors: Tracy Hampton
Journal: JAMA (2008)

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