tbuckley/cabot-search huggingface dataset:
Alcohol intake, smoking and illicit drug use in TB patients is under recorded by doctors
Authors: Katie Ward, Oliver Tavabie, Rachel Crane, Lynette Linkson, Paramita Palchaudhuri, Moerida Belton
Journal: European Respiratory Journal (2014)

Introduction : Use of alcohol, tobacco and illicit drugs influence the incidence and the outcome of TB. Taking a history of alcohol, tobacco and illicit drug use is an important part of patient assessment to help with patient care and service planning.Queen Elizabeth (QEH) is a hospital in Woolwich, London, serving a population of 500 000. 106 cases of TB were diagnosed in adults in 2013. Most present to QEH emergency department(ED)or TB clinic. Patients presenting via ED are admitted using a checklist with questions on alcohol, tobacco and illicit drug use. Clinic patient notes are made using free text. Method : Notes were requested for all cases of TB diagnosed 1 July to 31 Dec 2013 and reviewed to determine whether information on alcohol, tobacco and illicit drug use was recorded at the time of first presentation. Analyses were performed using SPSS.  Results : Notes were available for 41/55 cases(75%). Patients9 median age was 30; 28(68%) were male. 12(29%) had no record of alcohol intake, 10(24%) had no tobacco history; none had illicit drug use recorded. Further data in Figure 1  .  Discussion : Recording of alcohol, tobacco and illicit drug use was lacking; it tended to be better for men and those seen in ED. Failure to identify risk factors may impact on treatment and deny support to “at-risk” patients. Checklists can help ensure consistency and completeness. We plan to introduce a checklist to TB clinic and assess its impact.
Abstract 14205: Malondialdehyde-Modified Low-Density Lipoprotein to High-Density Lipoprotein Cholesterol Ratio Predicts Endothelial Dysfunction
Authors: Tomonori Sugiura, Yasuaki Dohi, Sumiyo Yamashita, Koji Yamamoto, Yoshimasa Wakamatsu, Satoru Tanaka, Yutaka Takeda, Nobuyuki Ohte, Genjiro Kimura
Journal: Circulation (2010)

Purpose: Endothelial dysfunction is a predictor of cardiovascular event as well as an initial step of atherosclerosis. Oxidative stress plays a major role in the process of endothelial damage and a...
An Afterlife in Reno
Authors: Floyd Skloot
Journal: JAMA (1998)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Down-regulation of L-type calcium channel and sarcoplasmic reticular Ca2+-ATPase mRNA in human atrial fibrillation without significant change in the mRNA of ryanodine receptor, calsequestrin and phospholamban
Authors: Ling-Ping Lai, Ming-Jai Su, Jiunn-Lee Lin, Fang-Yue Lin, Chang-Her Tsai, Yih-Sharng Chen, Shoei K.Stephen Huang, Yung-Zu Tseng, Wen-Pin Lien
Journal: Journal of the American College of Cardiology (1999)
The Role of Maintenance of Certification Programs in Governance and Professionalism
Authors: Paul S. Teirstein, Eric J. Topol
Journal: JAMA (2015)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Enlarged Thymus in a Patient With Dyspnea and Weight Loss
Authors: Wenyu Huang, Mark E. Molitch
Journal: JAMA (2015)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Abstract 13313: First Report of the New Point-of-Care TEG: a Multicenter Validation Study of the CORA® System
Authors: Paul A Gurbel, Kevin P Bliden, Amy L Monroe, Wendi L Slusser, Martin Gesheff, Christopher Franzese, Adina A Muresan, Norman E Brunner, G. Carlos, Peter R Delmenico, Eli Cohen, Gabriel Raviv, DeAnna L Haugen, Udaya S Tantry, Mark H Ereth
Journal: Circulation (2014)

Background: Thrombelastography (TEG) is an established but labor intensive method for assessing global hemostasis for the management of bleeding and thrombotic risk in surgical, cardiovascular, and trauma patients. We performed the initial validation study of the first true point-of-care TEG, the CORA® (COagulation Resonance Analyzer or TEG-6S system). CORA uses resonance-frequency viscoelasticity measurements and a disposable multi-channel microfluidic cartridge to assess hemostasis and response to antiplatelet therapy. Methods: TEG assays (n=5,100) were performed from the blood of healthy volunteers (n=160) and patients undergoing coronary revascularization (n=300) collected at 3 hospitals. Quality controls were also assayed. The performance of the TEG-6S system was compared with the conventional TEG 5000 system in accordance with Clinical Laboratory Standards Institute Guidelines. Results: Regression analysis demonstrated a strong correlation (R) between the two systems by all standard measures and a lower coefficient of variation (CV %) with the CORA system at all hospitals (Table). Receiver operating characteristic (ROC) curve analysis showed an excellent correlation between platelet mapping methods (AUC≥0.90, p&lt;0.001) and there was a substantial agreement for measuring antiplatelet response to aspirin (k=0.67, agreement=87%) and P2Y12 inhibitors (k=0.69, agreement=86%). Conclusion: The new point-of-care TEG-6S system is associated with improved precision, greater ease of use, and a strong correlation as compared to the conventional TEG 5000 system. The TEG-6S will facilitate future trials of personalized antiplatelet therapy and improve the assessment of bleeding and thrombotic risk in cardiovascular, surgical, and trauma patients.
Mechanistic Insights Into Posterior Mitral Leaflet Inter-Scallop Malcoaptation During Acute Ischemic Mitral Regurgitation
Authors: David T. Lai, Frederick A. Tibayan, Truls Myrmel, Tomasz A. Timek, Paul Dagum, George T. Daughters, David Liang, Neil B. Ingels, D. Craig Miller
Journal: Circulation (2002)

Three-dimensional dynamics of the 3 individual scallops within the posterior mitral leaflet during acute ischemic mitral regurgitations have not been previously measured.Radiopaque markers were sutured to the mitral annulus, papillary muscle tips, and leaflet edges in 13 sheep. Immediately postoperatively, under open-chest conditions, 3-D marker coordinates were obtained using high-speed biplane videofluoroscopy before and during echocardiographically verified acute ischemic mitral regurgitation produced by occlusion of the left circumflex coronary artery.During acute ischemic mitral regurgitation, at end systole, the anterolateral edge of the central scallop was displaced 0.8+/-0.9 mm laterally and 0.9+/-0.6 mm apically away from the anterolateral scallop; such displacement correlated with lateral displacement of the lateral annulus (R(2)=0.7, SEE=0.7 mm, P<0.001) and movement of the right lateral annulus away from the nonischemic anterior papillary tip (R(2)=0.6, SEE=0.8 mm, P=0.002), respectively. End-systolic displacement of the posteromedial edge of the central scallop was 1.4+/-0.9 mm anteriorly and 0.9+/-0.6 mm laterally away from the posteromedial scallop, corresponding to anterior displacement of the mid-lateral annulus (R(2)=0.5, SEE=1.0 mm, P<0.001).Malcoaptation of the scallops within the posterior leaflet during acute left ventricular ischemia is a novel observation. The primary geometric mechanism underlying scallop malcoaptation in acute ischemic mitral regurgitation was annular dilatation, which hindered leaflet coaptation by drawing the individual scallops apart. These findings support the use of annular reduction in the repair of ischemic mitral regurgitation and also suture closure of prominent subcommissures between posterior leaflet scallops.
Abstract 124: P21-activated protein kinase 1 high expression is a positive prognostic factor in human primary and metastatic pancreatic cancer
Authors: Shuqiang Yuan, Feng Wang, Han Juan, Hengying Pu, Zhiwei Zhou, Rui-hua Xu
Journal: Cancer Research (2015)

Abstract Background: P21-activated protein kinase 1 (PAK1), a main downstream effector of small Rho GTPases, is overexpressed in many malignancies. Its overexpression was associated with poor prognosis in some tumor types including breast cancer, gastric cancer, colorectal cancer and so on. However, the expression and clinical relevance of PAK1 expression in human pancreatic cancer remain unknown. Methods: The present study was designed to investigate the clinical and prognostic significance of PAK1 expression in pancreatic carcinoma. We examined the expression of PAK1 by immunohistochemistry in 72 primary pancreatic carcinoma samples and 20 liver metastatic samples. The relationships between PAK1 and clinicopathological parameters and prognosis in primary and metastatic pancreatic cancer were analyzed. Results: Among the total 92 cases, primary pancreatic cancer samples had significantly higher rate (38/72, 52.8%) of high PAK1 expression than liver metastatic samples (5/20, 25.0%) (p = 0.028). In 72 primary pancreatic cancer patients, high PAK1 expression was associated with younger age (p = 0.038) and moderately or well differentiated tumor (p = 0.007). Moreover, a positive relationship was found between high PAK1 expression and overall survival (OS) (p&amp;lt;0.005). Patients with high PAK1 expression had a better OS than those with low PAK1 expression. Univariate and multivariate analysis by Cox regression including PAK1 and other prognostic pathological markers demonstrated high PAK1 immunostaining as an independent prognostic factor for survival in pancreatic cancer patients (P&amp;lt;0.005). Conclusions: For the first time, we report that PAK1 is a novel prognostic marker for pathologically confirmed human pancreatic cancer. Reduced expression of p21-activated protein kinase 1 correlates with poor histological differentiation in pancreatic cancer. Note: This abstract was not presented at the meeting. Citation Format: Shuqiang Yuan, Feng Wang, Han Juan, Hengying Pu, Zhiwei Zhou, Rui-hua Xu. P21-activated protein kinase 1 high expression is a positive prognostic factor in human primary and metastatic pancreatic cancer. [abstract]. In: Proceedings of the 106th Annual Meeting of the American Association for Cancer Research; 2015 Apr 18-22; Philadelphia, PA. Philadelphia (PA): AACR; Cancer Res 2015;75(15 Suppl):Abstract nr 124. doi:10.1158/1538-7445.AM2015-124
Abstract #4692: Efficacy of IPI-504 \#8220;a novel inhibitor of heat shock protein 90\#8221; in a preclinical mouse model of gastrointestinal stromal tumor (GIST)
Authors: Giuseppe Floris, Maria Debiec-Rychter, Raf Sciot, Cristiana Stefan, Agnieszka Wozniak, Kathleen Machiels, Emmanuel Normant, Patrick Schöffski
Journal: Cancer Research (2009)

Background:  The inhibition of the chaperone heat shock protein 90 (Hsp90) by the Hsp90 inhibitor IPI-504 has emerged as an appealing strategy in the treatment of advanced GISTs. IPI-504 is an IV-administered water soluble Hsp90 inhibitor that has recently entered a phase III registration trial in GIST. In this study, we assessed the therapeutic potential of IPI-504 in imatinib-sensitive GIST xenografts, alone or in combination with imatinib.  Material and Methods:  Human GIST882 cells with a  KIT  exon 13 mutation were grafted bilaterally in 43 nude mice. Animals were randomized to four groups: A (n=13; control), B (n=18; IPI-504 100 mg/kg 3x/week p.o.), C (n=8; imatinib 50 mg/kg 2x/day p.o) and D (n=4; combination IPI-504/imatinib, same dose/schedule as above). Treatment lasted for 15 days. Histopathological assessment was done by HE however, the combination IPI-504 and imatinib produced a marked suppression of total KIT protein, which was accompanied by complete downregulation of the KIT signaling pathway. Loss of KIT protein expression in the combination arm was confirmed by immunostaining. Although KIT was not completely degraded with IPI-504 treatment, measurable effects on the phosphorylation levels of AKT, S6 and MAPK were observed.  Conclusions:  IPI-504 treatment has considerable effects on GIST xenografts resulting in tumor shrinkage, necrosis and myxoid degeneration. The combination of IPI-504 with a low dose of imatinib results in enhanced/additive anti-tumor activity in imatinib-sensitive GIST xenografts. These results provide a strong rationale for exploring IPI-504 in the clinical setting of GIST as single agent and in combination with tyrosine kinase inhibitors.     Citation Information:  In: Proc Am Assoc Cancer Res; 2009 Apr 18-22; Denver, CO. Philadelphia (PA): AACR; 2009. Abstract nr 4692.
Respiratory symptoms, lung function tests and airway responsiveness among automobile spray painters
Authors: Saso Stoleski, Jordan Minov, Jovanka Karadzinska-Bislimovska, Dragan Mijakoski
Journal: European Respiratory Journal (2014)

Objective:  To evaluate the frequency of respiratory symptoms, lung function test abnormalities and non specific bronchial hyperresponsiveness (BHR) among automobile spray painters.  Methods:  A cross sectional study was performed including 40 males (mean age= 39.6±9.2) employed as automobile spray painters (duration of exposure 14.8±6.4) and 40 male office workers as a control group (mean age=40.2±8.6) matched for age, smoking habits and socioeconomic status. Evaluation of examined subjects included completion of a questionnaire on respiratory symptoms in the last 12 months (cough, phlegm, dyspnea, wheezing, chest tightness, and nasal symptoms), spirometry and histamine challenge (PC20£8 mg/mL).  Results:  Automobile spray painters had a significantly higher prevalence of cough (32.1%), phlegm (17.3%), wheezing (12.5%), and nasal symptoms (9.7%) than the control group (p 1 , FEV 1 /FVC%, MEF 75 , MEF 50 , and MEF 25 ) were lower in automobile spray painters compared with the controls, but statistical significance was found only for MEF 25,  MEF 50 , and MEF 75  (p=0.04, p=0.02, and p=0.004; respectively). The prevalence of non specific BHR, defined by histamine PC20 less than 8 mg/mL, was higher in automobile spray painters but statistical significance was yet not reached (23.4%  vs.  13.8%).   Conclusion:  Our obtained results from the study suggest that occupational exposure among automobile spray painters is associated with a higher prevalence of respiratory and nasal symptoms, lung function impairment and higher prevalence of non specific airway responsiveness.
Physiology of the Gastrointestinal Tract.
Authors: Graeme Duthie, Angie Gardner
Journal: Annals of Internal Medicine (1987)

The Role of The Nurse Practitioner in Clinical Physiology. Iindications for Gastrointestinal Physiological Assessment. Pathophysical correlations in Upper Gastrointestinal Physiology. Manometry and pH of The upper Gastrointestinal Tract. Breath Testing and its Interpretation. Pathophysiological Correlations in Anorectal Conditions. Anorectal Physiology. Functional Radiology of The Gastrointestinal Tract. Anorectal Ultrasonography. Biofeedback and Anorectal Disease. Developing Methods in Physiological assessment.
Impact of bone marrow transplantation for symptomatic sickle cell disease: an interim report
Authors: Mark C. Walters, Rainer Storb, Melinda Patience, Wendy Leisenring, Terri Taylor, Jean E. Sanders, George E. Buchanan, Zora R. Rogers, Patricia Dinndorf, Sally C. Davies, Irene A G Roberts, Rosarita Dickerhoff, Andrew M. Yeager, Hsu Lewis, Joanne Kurtzberg, Kwaku Ohene-Frempong, Nancy Bunin, Francoise Bernaudin, Wing Yen Wong, J. Paul Scott, David Margolis, Elliott Vichinsky, Donna A. Wall, Allen S. Wayne, Charles Pegelow, Rupa Redding-Lallinger, Joseph Wiley, Martin Klemperer, William C. Mentzer, Franklin O. Smith, Keith M. Sullivan
Journal: Blood (2000)
Doctors face murder charges in Libya
Authors: Carl Kovac, Radko Khandjiev
Journal: BMJ (2001)

Sixteen doctors, nurses, and managers at the Al-Fateh Hospital in Benghazi, Libya, are standing trial in Tripoli. All are charged with subverting the country's healthcare system, and seven are charged with murder. The trial, which has been adjourned several times, is scheduled to resume next week.

According to an 11 count indictment issued by the People's Claim Bureau, seven of the defendants are charged with murdering 393 children at the Al-Fateh hospital in 1998 by injecting them with HIV. …
PU.1 inhibits GATA-1 function and erythroid differentiation by blocking GATA-1 DNA binding
Authors: Pu Zhang, Xiaobo Zhang, Atsushi Iwama, Channing Yu, Kent A. Smith, Beatrice U. Mueller, Salaija Narravula, Bruce E. Torbett, Stuart H. Orkin, Daniel G. Tenen
Journal: Blood (2000)
Prescription Opioid Duration of Action and the Risk of Unintentional Overdose—Reply
Authors: Matthew Miller, Catherine W. Barber, Sarah Leatherman
Journal: JAMA Internal Medicine (2015)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Internal Medicine HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Internal Medicine journal
The c-kit Ligand Stem Cell Factor and Anti-IgE Promote Expression of Monocyte Chemoattractant Protein-1 in Human Lung Mast Cells
Authors: Mehrdad Baghestanian, Roland Hofbauer, Hans P. Kiener, Hans C. Bankl, Friedrich Wimazal, Martin Willheim, Otto Scheiner, Wolfgang Füreder, Michael R. Müller, Dorian Bevec, Klaus Lechner, Peter Valent
Journal: Blood (1997)
Abstract 15957: A Simple Ablation Strategy Targeting Exclusively AF Triggers is Equally Effective for Paroxysmal and Persistent Atrial Fibrillation: Single Center Large Series
Authors: Kiyoshi Otomo, Kaname Takizawa, Naoto Inoue, Taiichiro Meguro
Journal: Circulation (2014)

Backgrounds: Recent studies reported that the ablation strategies including ganglionated plexi ablation, linear ablation and ablation of complex and fractionated electrograms and atrial fibrillation (AF) rotors in conjunction with pulmonary vein isolation (PVI) were superior to the conventional ablation strategy aimed to eliminate AF triggers in terms of post-ablation clinical outcomes. It is controversial whether addition of above-mentioned supplementary ablation to PVI improves post-ablation clinical outcomes in persistent AF (PeAF). Purposes: To test the post-ablation clinical outcomes of our ablation strategy exclusively targeting AF triggers in paroxysmal (PAF) and PeAF, and to compare the post-ablation clinical outcomes between PAF and PeAF in a single center large series. Methods: Consecutive 1183 patients (pts) (age: 64±11 years, LA diameter: 40±6mm) with PAF (988 pts (84%)) or PeAF (195 pts (16%), AF duration: 5±3 months (range: 1-11)) who received ablation procedures in our institution were included. Irrespective of AF types, the procedure consisted of encircling PVI (EPVI) and SVC isolation (SVCI) in all pts, and additional ablation targeting non-PV, non-SVC AF triggers if spontaneous AF initiation was observed by high dose (100-400μg/hr) isoproterenol (ISP) infusion and bolus administration of 40mg of adenosine triphosphate (ATP) during ISP infusion. Procedure end point was complete elimination of spontaneous AF initiation on by ISP infusion and ATP boluses. Results: Total of 1949 procedures were performed in all 1183 pts (1.3±0.5/pt, range: 1-4). EPVI and SVCI were successful in all pts. Non-PV, non-SVC AF triggers were identified in 50 pts (4%) and eliminated by focal ablation in 42 (84%). Kaplan-Meier analysis revealed similarly favorable recurrence-free survivals after the last ablation procedure without antiarrhythmic drugs (blanking period of 1 month) in both PAF and PeAF groups (945 (96%)/988 vs. 190 (97%)/195; p&gt;0.05, follow-up period: 414±245 days (median: 395)). Conclusions: This study exhibited that post-ablation recurrence-free survivals were similar between PAF and PeAF, even if only AF triggers were targeted. An ablation strategy targeting only AF triggers may be sufficient in both PAF and PeAF.