Spurious Serum Creatinine Elevations in Ketoacidosis
Authors: MARK E. MOLITCH
Journal: Annals of Internal Medicine (1980)

Brief Reports1 August 1980Spurious Serum Creatinine Elevations in KetoacidosisMARK E. MOLITCH, M.D., ELISE RODMAN, M.D., CARL A. HIRSCH, M.D., ELI DUBINSKY, M.D.MARK E. MOLITCH, M.D., ELISE RODMAN, M.D., CARL A. HIRSCH, M.D., ELI DUBINSKY, M.D.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-93-2-280 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptDiabetic ketoacidosis is usually accompanied by dehydration resulting in prerenal azotemia, in which the levels of blood urea nitrogen are elevated out of proportion to those of the serum creatinine (1).In contrast, one patient who had been admitted to our hospital in diabetic ketoacidosis a number of times consistently displayed serum creatinine levels repeatedly elevated out of proportion to her blood urea nitrogen levels but had normal renal function between episodes of ketoacidosis. Investigation showed the elevated creatinine levels to be due to the artifactual interference of acetoacetate in the automated measurement of serum creatinine, a fact not widely...References1. DOSSETOR J. Creatininemia versus uremia: the relative significance of blood urea nitrogen and serum creatinine concentration in azotemia. Ann Intern Med. 1966;65:1287-99. LinkGoogle Scholar2. Technicon Autoanalyzer Methodology (N method file N-11 b). Tarrytown, New York: Technicon Corporation; 1969. Google Scholar3. Beckman Creatinine Analyzer 2 Operating Manual (Beckman Instructions 015555443). Fullerton, California: Beckman Instruments, Inc. ; 1977. Google Scholar4. STOTEN A. A micromethod for creatinine using resin to remove interfering substances. J Med Lab Technol. 1968;25:240-7. Google Scholar5. WATKINS P. The effect of ketone bodies on the determination of creatinine. Clin Chim Acta. 1967;18:191-6. CrossrefMedlineGoogle Scholar6. FABINYERTINGSHAUSEN DG. Automated reaction-rate method for determination of serum creatinine with the CentrifiChem. Clin Chem. 1971;17:696-700. CrossrefMedlineGoogle Scholar7. LARSEN K. Creatinine assay by a reaction kinetic principle. Clin Chim Acta. 1972;41:209-17. CrossrefMedlineGoogle Scholar8. LUSTGARTENWENK JR. Simple, rapid, kinetic method for serum creatinine measurement. Clin Chem. 1972;18:1419-22. CrossrefMedlineGoogle Scholar9. ROMEO J. Evaluation of kinetic method for creatinine. Lab Med. 1975;6:15-8. CrossrefGoogle Scholar10. SOLDINHENDERSONHILL SLJ. The effect of bilirubin and ketones on reaction rate methods for the measurement of creatinine. Clin Biochem. 1978;11:82-6. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. 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