tbuckley/cabot-search huggingface dataset:
An Overview of Public Policy and Infectious Diseases
Authors: HENRY E. SIMMONS
Journal: Annals of Internal Medicine (1978)

Major problems face this nation's health care system; infectious disease and their management are a major and growing part of these problems. It is clear from available information that 40 years after the introduction of the sulfonamides, infection and its management remain an enormously important cause of morbidity and mortality. We are far from being in the "post-infectious-disease era." Unless society and the medical profession understand this and take vigorous remedial steps, our problems may intensify, despite the availability of a remarkable effective group of therapeutic agents.
Magnified endoscopic findings of gastric low-grade mucosa-associated lymphoid tissue lymphoma
Authors: H. Isomoto, S. Shikuwa, N. Yamaguchi, K. Miyazato, K. Ohnita, T. Hayashi, Y. Mizuta, M. Ito, S. Kohno
Journal: Endoscopy (2008)

We report magnified endoscopic findings of gastric low-grade mucosa-associated lymphoid tissue (MALT) lymphoma before and after anti-tumor therapies. Magnifying chromoendoscopy with crystal violet was carried out in nine patients with low-grade MALT lymphoma of the gastric corpus with Helicobacter plyori infection. A Wotherspoon histologic score of 5 was used as the criterion to make the histopathologic diagnosis. On conventional endoscopy, each patient was classified as having a superficial spreading type of the lymphoma, varying from gastritis to adenocarcinoma-like appearance. Anti-H. pylori treatment was successful in all cases. Complete regression was observed in six of the nine patients with MALT lymphoma and no regression was seen in three during the median follow-up of 12 months. Magnified endoscopic findings consisted exclusively of irregular and destroyed gastric pits in the lymphoma lesions. Histopathologic examination of targeted biopsies obtained from the affected mucosa with the abnormal pit pattern revealed the characteristic features of lymphoepithelial lesions and centrocyte-like cell infiltration. In six patients who underwent repeat magnifying endoscopy at 6 months or more after anti-tumor therapies (five with complete regression following anti-H. pylori therapy and one who had been treated with radiation), the abnormal pits appeared to have returned to normal. Magnifying endoscopy can reliably identify irregular and destructive pit patterns in the lymphoma lesions, and aid the prediction of histopathlogic regression.
Cervical Discography Defended
Authors: Ralph B. Cloward
Journal: JAMA (1975)

ABSTRACT To the Editor.— When Earl P. Holt, Jr., MD, published his first article on cervical discography (188:799, 1964), I chose to make no public comment because his conclusions were based on  poorly executed, improperly interpreted, nonscientific experiment. It was the hope of those of us who considered cervical discography  valuable diagnostic procedure that Holt's conclusions, and those of others who agree with him, would be disregarded.But in regard to Dr. Holt's most recent writing in The Journal on this subject (231:613, 1975), it was difficult for me to exercise restraint to comment on his attempt to strengthen his original conclusion that cervical discography has no diagnostic value. He now states that it should be abolished and demands a hard and fast moratorium on the procedure. In this report, ten years later than the first, Holt states that evidence has accumulated to uphold [his original] views. However, he
N-acetylcysteine Amide Augments the Therapeutic Effect of Neural Stem Cell-Based Antiglioma Oncolytic Virotherapy
Authors: Chung Kwon Kim, Atique U Ahmed, Brenda Auffinger, Ilya V Ulasov, Alex L Tobias, Kyung-Sub Moon, Maciej S Lesniak
Journal: Molecular Therapy (2013)

Current research has evaluated the intrinsic tumor-tropic properties of stem cell carriers for targeted anticancer therapy. Our laboratory has been extensively studying in the preclinical setting, the role of neural stem cells (NSCs) as delivery vehicles of CRAd-S-pk7, a gliomatropic oncolytic adenovirus (OV). However, the mediated toxicity of therapeutic payloads, such as oncolytic adenoviruses, toward cell carriers has significantly limited this targeted delivery approach. Following this rationale, in this study, we assessed the role of a novel antioxidant thiol, N-acetylcysteine amide (NACA), to prevent OV-mediated toxicity toward NSC carriers in an orthotropic glioma xenograft mouse model. Our results show that the combination of NACA and CRAd-S-pk7 not only increases the viability of these cell carriers by preventing reactive oxygen species (ROS)-induced apoptosis of NSCs, but also improves the production of viral progeny in HB1.F3.CD NSCs. In an intracranial xenograft mouse model, the combination treatment of NACA and NSCs loaded with CRAd-S-pk7 showed enhanced CRAd-S-pk7 production and distribution in malignant tissues, which improves the therapeutic efficacy of NSC-based targeted antiglioma oncolytic virotherapy. These data demonstrate that the combination of NACA and NSCs loaded with CRAd-S-pk7 may be a desirable strategy to improve the therapeutic efficacy of antiglioma oncolytic virotherapy. Current research has evaluated the intrinsic tumor-tropic properties of stem cell carriers for targeted anticancer therapy. Our laboratory has been extensively studying in the preclinical setting, the role of neural stem cells (NSCs) as delivery vehicles of CRAd-S-pk7, a gliomatropic oncolytic adenovirus (OV). However, the mediated toxicity of therapeutic payloads, such as oncolytic adenoviruses, toward cell carriers has significantly limited this targeted delivery approach. Following this rationale, in this study, we assessed the role of a novel antioxidant thiol, N-acetylcysteine amide (NACA), to prevent OV-mediated toxicity toward NSC carriers in an orthotropic glioma xenograft mouse model. Our results show that the combination of NACA and CRAd-S-pk7 not only increases the viability of these cell carriers by preventing reactive oxygen species (ROS)-induced apoptosis of NSCs, but also improves the production of viral progeny in HB1.F3.CD NSCs. In an intracranial xenograft mouse model, the combination treatment of NACA and NSCs loaded with CRAd-S-pk7 showed enhanced CRAd-S-pk7 production and distribution in malignant tissues, which improves the therapeutic efficacy of NSC-based targeted antiglioma oncolytic virotherapy. These data demonstrate that the combination of NACA and NSCs loaded with CRAd-S-pk7 may be a desirable strategy to improve the therapeutic efficacy of antiglioma oncolytic virotherapy.
Venous ulcers may be associated with gravitational eczema
Authors: C M Quartey-Papafio
Journal: BMJ (2002)

EDITOR—Chan et al report on several patients treated with four layer compression bandaging for venous ulceration who went on to develop toe and cleft ulceration.1 In south Lincolnshire, patients with venous ulcers have been treated with such bandaging in the community by district nurses since the late 1990s. Before then only selected patients were …
Human Immunodeficiency Virus Infection in Transplant Recipients
Authors: Christian Hiesse, B. Charpentier, D. Fries, G Simonneau, J. F. Delfraissy
Journal: Annals of Internal Medicine (1986)

Letters and Corrections1 August 1986Human Immunodeficiency Virus Infection in Transplant RecipientsCHRISTIAN HIESSE, M.D., B. CHARPENTIER, M.D., D. FRIES, M.D., G SIMONNEAU, M.D., J. F. DELFRAISSY, M.D.CHRISTIAN HIESSE, M.D.Search for more papers by this author, B. CHARPENTIER, M.D.Search for more papers by this author, D. FRIES, M.D.Search for more papers by this author, G SIMONNEAU, M.D.Search for more papers by this author, J. F. DELFRAISSY, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-105-2-301_1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: Recent reports have focused attention on recipients of kidney allografts or transfusions from donors infected with the human immunodeficiency virus (HIV; formerly known as HTLV-III/LAV) (1-4). The question remains as to whether immunosuppressive therapy in such patients alters the course of HIV infection and enhances the development of full-blown acquired immunodeficiency syndrome (AIDS).Since January 1984, 250 patients who received kidney transplants in our institution have been screened for anti-HIV antibodies by radioimmunoprecipitation assay (cysteine) at 6 months after transplantation. Since August 1985, all recipients (tested 1 day before transplantation), kidney donors, and blood-products donors have been...References1. PROMPTREISGRILLO CMF. Transmission of AIDS virus at renal transplantation. Lancet. 1985;2:672. CrossrefMedlineGoogle Scholar2. LANGBUISSONFOUCHER PAA. Unusual immune deficiency syndrome associated with LAV/HTLV-III infection in a transplant patient. Transplant Proc. 1986. (In press). Google Scholar3. MILGROMESQUENAZIFULLER MLL. Acquired immunodeficiency syndrome in a transplant patient. Transplant Proc. 1985;17:75-6. Google Scholar4. L'AGE-STEHRSCHWARTZOFFERMANN JAG. HTLV-III infection in kidney transplant recipients. Lancet. 1985;2:1361-6. CrossrefMedlineGoogle Scholar5. GLUCKMANKLATZMANN JD. Facteurs de risque de SIDA en néphrologie. Sémin Uro-Néphrol. 1986;112-22. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Hôpital Antoine Béclère; Clamart, France PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByEncephalitis Caused by Pathogens Transmitted through Organ Transplants, United States, 2002–2013Transfusion sanguine et transplantationEffects of cyclosporin on T-cell subsets in human immunodeficiency virus disease 1 August 1986Volume 105, Issue 2Page: 301-301KeywordsAIDSAntibodiesHIVHIV infectionsImmunosuppressivesRenal transplantationTransplantation Issue Published: 1 August 1986 PDF DownloadLoading ...
Two-Dimensional Speckle Tracking Echocardiography for Assessment of Early Cardiac Function after Treatment of Patients with Overt Hypothyroidism
Authors: Ercan Erdoğan, Mehmet Akkaya, Ahmet Bacaksız, Abdurrahman Tasal, Seref Kul, Osman Sonmez, Murat Turfan, Mehmet Akif Vatankulu, Emin Asoğlu, Emrah Sevgili, Mehmet Ergelen, Hüseyin Uyarel, Omer Göktekin
Journal: Journal of the American College of Cardiology (2013)
Late Vascular Response to Repeat Stenting for In-Stent Restenosis With and Without Radiation
Authors: Yoshihiro Morino, Thosaphol Limpijankit, Yasuhiro Honda, Alexandra J. Lansky, Ron Waksman, Heidi N. Bonneau, Paul G. Yock, Gary S. Mintz, Peter J. Fitzgerald
Journal: Circulation (2002)

Re-stenting of in-stent restenosis (ISR) improves acute angiographic results. Methods and Results- Volumetric intravascular ultrasound analysis was performed in 70 ISR lesions that received either placebo (n=36) or (192)Ir radiation (n=34). ISR lesions treated by re-stenting were divided into 3 groups: old stent not re-stented (A), old/new stent overlap (B), and new stent only (C). ISR lesions treated without re-stenting were categorized as D. In placebo patients, postintervention lumen volume index (LVI) was significantly greater in re-stented segments B and C than in non-re-stented segment A (P<0.05).At follow-up, however, LVI was similar in all 4 segments secondary to the increased intimal hyperplasia (IH) reaccumulation within the re-stented segments. In patients treated with (192)Ir radiation, LVI was maintained from baseline to follow-up only in non-re-stented segments A and D. Conversely, there was a significant decrease in LVI in re-stented segments B and C (P<0.05). Qualitatively, 79% of patients in the irradiated group had stent struts with undetectable neointimal versus only 27% in the placebo group (P<0.001). Coefficient of variation of IH reaccumulation was greater in re-stented segments of (192)Ir patients (B=57.3% and C=58.9%) than in re-stented segments in placebo patients (B=27.3% and C 26.8%) and non-re-stented segments in irradiated patients.Additional lumen gain from re-stenting ISR lesions is counteracted by exaggerated neointimal proliferation in placebo patients. Maximum effectiveness and safety of radiation can be achieved for ISR lesions when treated without re-stenting. Thus, regardless of supplementary intravascular brachytherapy, repeat stenting strategies provided little long-term advantage.
Serum Urate Concentrations Among University Professors
Authors: George W. Brooks
Journal: JAMA (1966)

The purpose of this study was to test the hypothesis that personal characteristics of drive, achievement, and leadership are positively associated with the level of uric acid in the serum. Among seven behavior scales which were developed, drive, achievement, and leadership correlated most highly with serum urate levels. The correlation coefficient between the total of all behavior scales and serum urate in 51 University of Michigan professors was r = 0.66, a very high order of relationship for such studies between behavior variables and physiological ones. The results of this study lend substantial support to the hypotheses that a tendency to gout is a tendency to the executive suite, and that serum uric acid is related to behavioral characteristics that lead to outstanding performance. There is now a need for pharmacological experiments to see if the concept of serum urate as an endogenous cortical stimulant can also be supported.
Adjunctive intracoronary infusion of antithrombin III during percutaneous transluminal coronary angioplasty. Results of a prospective, randomized trial.
Authors: V Schächinger, M Allert, W Kasper, H Just, W Vach, A M Zeiher
Journal: Circulation (1994)

BACKGROUND Heparin needs the plasma protein antithrombin III to function as an inhibitor of thrombin, and local antithrombin III deficiency might therefore limit the antithrombotic effectiveness of heparin during percutaneous transluminal coronary angioplasty. METHODS AND RESULTS In the present double-blind study, 615 consecutive patients undergoing percutaneous transluminal coronary angioplasty (PTCA), of a total of 713 stenoses, were prospectively randomized to receive a bolus injection of 15,000 U heparin followed by a continuous intracoronary infusion via the guiding catheter of either 250 U heparin per minute or 250 U heparin plus 25 U antithrombin III per minute during the procedure. Four clinical variables, 19 lesion-specific characteristics, and 16 procedure-related variables were evaluated. Procedural success was assessed by quantitative angiography; procedure-related ischemic complications were analyzed during in-hospital follow-up. Procedural success rates (&lt; 50% final diameter stenosis and no major ischemic complication) were similar, with 85% in the heparin group (n = 324 patients) and 83% in the heparin+antithrombin III group (n = 291 patients). Percent diameter stenosis after PTCA was 39 +/- 18% in the heparin group and 40 +/- 20% in the heparin+antithrombin III group (NS). There were no differences between the two groups with respect to PTCA-related acute vessel occlusion, angiographic evidence of intracoronary thrombus formation, post-procedure creatine kinase increase, Q-wave myocardial infarction, or emergency coronary artery bypass surgery. High-risk subgroup analysis revealed no beneficial effect of adjunctive intracoronary antithrombin III in any of the analyzed subgroups. In addition, although risk stratification according to the criteria of the American College of Cardiology/American Heart Association Task Force classification proved to be very useful for the entire study population, no beneficial effect of intracoronary antithrombin III infusion was observed in any of the different risk groups. CONCLUSIONS Compared with heparin alone, adjunctive intracoronary antithrombin III therapy does not appear to have any beneficial effect on procedural outcome as well as type and frequency of acute complications during PTCA even in subgroups of patients with a high risk for thrombotic complications. Thus, a local deficiency of antithrombin III does not play a major role for the failure of heparin to abolish thrombotic complications during PTCA.
Nonalcoholic fatty liver disease (NAFLD): Is it really a serious condition?
Authors: Julia Wattacheril, Naga Chalasani
Journal: Hepatology (2012)

OBJECTIVE: To evaluate the association between non-alcoholic fatty liver disease and all cause and cause specific mortality in a representative sample of the US general population. DESIGN: Prospective cohort study. SETTING: US Third National Health and Nutrition Examination Survey (NHANES III: 1988-94) with follow-up of mortality to 2006. PARTICIPANTS: 11,371 adults aged 20-74 participating in the Third National Health and Nutrition Examination Survey, with assessment of hepatic steatosis. MAIN OUTCOME MEASURE: Mortality from all causes, cardiovascular disease, cancer, and liver disease (up to 18 years of follow-up). RESULTS: The prevalence of non-alcoholic fatty liver disease with and without increased levels of liver enzymes in the population was 3.1% and 16.4%, respectively. Compared with participants without steatosis, those with non-alcoholic fatty liver disease but normal liver enzyme levels had multivariate adjusted hazard ratios for deaths from all causes of 0.92 (95% confidence interval 0.78 to 1.09), from cardiovascular disease of 0.86 (0.67 to 1.12), from cancer of 0.92 (0.67 to 1.27), and from liver disease of 0.64 (0.12 to 3.59). Compared with participants without steatosis, those with non-alcoholic fatty liver disease and increased liver enzyme levels had adjusted hazard ratios for deaths from all causes of 0.80 (0.52 to 1.22), from cardiovascular disease of 0.59 (0.29 to 1.20), from cancer of 0.53 (0.26 to 1.10), and from liver disease of 1.17 (0.15 to 8.93). CONCLUSIONS: Non-alcoholic fatty liver disease was not associated with an increased risk of death from all causes, cardiovascular disease, cancer, or liver disease.
Neurological deficit associated with Mycoplasma pneumoniae reversed by plasma exchange.
Authors: F E Cotter, D Bainbridge, A C Newland
Journal: BMJ (1983)

kPa (78 mm Hg), carbon dioxide pressure 3-3 kPa (25 mm Hg), bicarbonate concentration 14-0 mmol/l, and pH 7-4.She was admitted to the intensive care unit and within 12 hours had regained consciousness.Renal and hepatic function remained normal throughout the illness.When her home was searched a strong-smelling substance in a rum bottle was found.Toxicological analysis confirmed that this was not rum but butanone (methyl ethyl ketone).Gas-liquid chromatography showed butanone to be present in her plasma in high concentration (13-2 mmol/l (95 mg/100 ml)) and in her urine.The plasma lactate concentration in blood taken at the time of admission was also raised (14-3 mmol/l (129 mg/100 ml)).She made a complete and uneventful recovery and was discharged from hospital after one week.She denied having swallowed anything unusual.We can only presume that she had sought solace from her chickenpox rash but that the rum bottle had inadvertently been filled with butanone.
Temperature, air pollution, and hospitalization for cardiovascular diseases among elderly people in Denver.
Authors: Petra J M Koken, Warren T Piver, Frank Ye, Anne Elixhauser, Lola M Olsen, Christopher J Portier
Journal: Environmental Health Perspectives (2003)

Daily measures of maximum temperature, particulate matter less than or equal to 10 micro m in aerodynamic diameter (PM10), and gaseous pollution (ozone, nitrogen dioxide, sulfur dioxide, and carbon monoxide) were collected in Denver, Colorado, in July and August between 1993 and 1997. We then compared these exposures with concurrent data on the number of daily hospital admissions for cardiovascular diseases in men and women > 65 years of age. Generalized linear models, assuming a Poisson error structure for the selected cardiovascular disease hospital admissions, were constructed to evaluate the associations with air pollution and temperature. After adjusting the admission data for yearly trends, day-of-week effects, ambient maximum temperature, and dew point temperature, we studied the associations of the pollutants in single-pollutant models with lag times of 0-4 days. The results suggest that O3 is associated with an increase in the risk of hospitalization for acute myocardial infarction, coronary atherosclerosis, and pulmonary heart disease. SO2 appears to be related to increased hospital stays for cardiac dysrhythmias, and CO is significantly associated with congestive heart failure. No association was found between particulate matter or NO2 and any of the health outcomes. Males tend to have higher numbers of hospital admissions than do females for all of the selected cardiovascular diseases, except for congestive heart failure. Higher temperatures appear to be an important factor in increasing the frequency of hospitalization for acute myocardial infarction and congestive heart failure, and are associated with a decrease in the frequency of visits for coronary atherosclerosis and pulmonary heart disease.
Dose assessment analogies.
Authors: B Lindell
Journal: Environmental Health Perspectives (1978)

Assessments of radiation detriment are based on the absorbed dose in the organs and tissues of interest, assuming a linear, nonthreshold dose--response relationship for the induction of cancer or genetic effects at low doses. Similar assessments may be made for nonradioactive, mutagenic, or carcinogenic substances, in which case the time integral of the local tissue concentration of the substance may be the quantity which would correspond to the radiation dose. It can be shown that the assessment then involves calculations which are very similar to those made in the assessment of radiation detriment. It is suggested that an attempt should be made to make such assessments for nonradioactive pollutants, in order to provide a more appropriate basis for comparisons with radiation detriments. In the assessment of the detriment from inhaled substances, the overall collective intake commitment is simply the total amount of each substance ever to be inhaled, irrespective of when or where. This quantity might be assumed to be proportional to the total detriment in form of lung cancer.
Circulating immune complexes, serum immunoglobulins, and acute phase proteins in psoriasis and psoriatic arthritis.
Authors: M R Laurent, G S Panayi, P Shepherd
Journal: Annals of the Rheumatic Diseases (1981)

Raised levels of circulating immune complexes were found in the plasma of 47% of patients with psoriasis and in 58% of those with psoriatic arthritis. The mean levels were significantly raised when compared with normals, but there was no difference between the 2 patient groups. The levels of acute phase proteins (C-reactive protein, fibrinogen, alpha-1-antitrypsin, and the 9th component of complement) were normal in those patients with psoriasis but were significantly raised in patients with psoriatic arthritis. Serum immunoglobulin G and A levels were equally raised in both patient groups, immunoglobulin M being normal. C-reactive protein and fibrinogen gave the best correlation with the clinical index of disease activity.
Genetic Linkage Analysis of Autosomal Dominant Congenital Cataracts with Lens-specific DNA Probes and Polymorphic Phenotypic Markers
Authors: David J. Barrett, Robert S. Sparkes, Michael B. Gorin, Suraj P. Bhat, M. Anne Spence, Mary L. Marazita, J. Bronwyn Bateman
Journal: Ophthalmology (1988)