tbuckley/cabot-search huggingface dataset:
<i>Brassica oleracea</i> pollen, a new source of occupational allergens
Authors: H. K. Hermanides, A. M. Laheÿ‐ de Boer, L. Zuidmeer, C. Guikers, R. van Ree, A. C. Knulst
Journal: Allergy (2006)

Background: Vegetable pollen is a rare source of occupational allergens. Occupational allergy has only been described in the case of paprika pollen and tomato pollen. We describe a new source of occupational pollen allergy. Aim: To study the incidence and the impact of broccoli and cauliflower pollen allergy in employees involved in classical plant breeding. Methods: Fifty‐four employees of five companies working with cauliflower ( Brassica oleracea botrytis ) and broccoli ( B. oleracea italica / cymosa ) pollen were eligible for complete evaluation. Allergy to cauliflower and broccoli pollen was evaluated by questionnaire and determination of sensitization by radioallergosorbent test (RAST) and skin‐prick tests (SPT). SPT and RAST were performed with a panel of commercial and homemade extracts from cauliflower and broccoli pollen. Results: Work‐related symptoms such as rhinitis, conjunctivitis, asthma and urticaria caused by B. oleracea pollen were reported by 44% of the participants (24/54), of whom all but one had positive SPT for cauliflower‐ and/or broccoli‐pollen/flower extracts and 58% (14/24) had positive RAST results. Symptoms had developed within the first 2 years in 33% of the patients. Six patients had to stop or change work. Conclusions: Brassica oleracea pollen is a new source of occupational allergen with strong allergenic potential leading to symptoms in almost half of the exposed employees.
Review: Spot protein–creatinine ratio has moderate diagnostic performance for proteinuria in pregnant women with hypertension
Authors: Christopher J. Robinson
Journal: Annals of Internal Medicine (2008)

Source Citation Côté AM, Brown MA, Lam E, et al. Diagnostic accuracy of urinary spot protein:creatinine ratio for proteinuria in hypertensive pregnant women: systematic review. BMJ. 2008;336:1003-6. 18403498
Itraconazole for the treatment of tinea pedis: A dosage of 400 mg/day given for 1 week is similar in efficacy to 100 or 200 mg/day given for 2 to 4 weeks
Authors: Aditya K. Gupta, Piet De Doncker, Annie Heremans, Paul Stoffels, Gérald E. Piérard, J. Decroix, M. Heenen, Hugo Degreef
Journal: Journal of the American Academy of Dermatology (1997)
Oligoclonal immunoglobulins and plasma cells in spinal fluid of patients with multiple sclerosis.
Authors: E J Thompson, P Kaufmann, R C Shortman, P Rudge, W I McDonald
Journal: BMJ (1979)

A new modification of polyacrylamide gel electrophoresis (PAGE) was applied to cerebrospinal fluid proteins from patients with multiple sclerosis (MS). The same spinal fluids were also examined by a cytological technique. Over 90% of patients with clinically definite or early probable or latent MS showed abnormal PAGE patterns in the form of oligoclonal gammaglobulin bands. Reactive (atypical, large) lymphocytes or typical plasma cells were found in some patients. In all such cases an oligoclonal pattern was present. The findings of oligoclonal bands provides valuable supporting evidence for the diagnosis of MS in the less definite clinical categories.
Dipyridamole-dobutamine echocardiography: A novel test for the detection of milder forms of coronary artery disease
Authors: Miodrag Ostojic, Eugenio Picano, Branko Beleslin, Ana Dordjevic-Dikic, Alessandro Distante, Jelena Stepanovic, Barbara Reisenhofer, Rade Babic, Sinisa Stojkovic, Milan Nedeljkovic, Goran Stankovic, Slavko Simeunovic, Vladimir Kanjuh
Journal: Journal of the American College of Cardiology (1994)
SOME NEW STUDIES OF THE OPIUM DISEASE.Read before the Philadelphia County Medical Society, January 27, 1892.
Authors: T. D. CROTIIERS
Journal: JAMA (1892)

As a preface, I wish to express my emphatic dissent against the common use of the word<i>habit</i>, in describing the opium disease. The popular meaning conveyed by this term is some state or condition voluntarily acquired and retained, with the certainty of being thrown off at any time at the will of the patient. This view assumes a knowledge of the physiology and psychology of the brain and its functions that is not yet attained. Hence the use of the word is incorrect, wrong, and contradicted by the facts in the clinical history of each case. It also conveys a false impression of the nature and origin of such cases, and is a word to which different meanings will always be given. No other word is more misleading and confusing, when applied to opium, alcohol, and other border-land neuroses. Beyond all question, the toxic use of opium and its
Bicentennial Cancer Mole
Authors: Menelaos A. Aliapoulios
Journal: JAMA (1976)

<h3>To the Editor.—</h3> The elegantly illustrated and informative article entitled "Early Detection of Primary Cutaneous Malignant Melanoma"<sup>1</sup>is currently being circulated by the Professional Education Committee of the American Cancer Society. The color atlas will doubtless be an invaluable tool for and guide to increasing the awareness and identification of malignant melanoma. Inasmuch as the distinguishing color characteristics of malignant melanoma are not black but shades of red, white, or blue or any combination of these, it might be particularly timely this year to refer to this lesion as the "bicentennial cancer mole," in deference to the tricolor coincidence. This notion evolved recently during a discussion of possible ways of increasing public awareness of this lesion that has an incidence of five cases per 100,000 per year and is infinitely more curable when discovered early.
WEB 2086 inhibits neutrophil dependent increases in coronary resistance in blood perfused rabbit heart
Authors: J R Tippins, J W Antoniw, M R Alison, B Garvey, A Maseri
Journal: Cardiovascular Research (1992)

The aim was to investigate the mechanism of the pressor action of the chemotactic peptide formyl-methionyl-leucyl-phenylalanine in the blood perfused Langendorff preparation of the isolated rabbit heart; and in particular to establish whether the response was dependent on the presence of neutrophils and whether the release of platelet activating factor contributed to the pressor effect.An isolated rabbit heart was perfused with blood from an anesthetised support rabbit. Formyl-methionyl-leucyl-phenylalanine was injected intra-arterially proximal to the isolated heart and measures of cardiac performance recorded. In some experiments the support animal was depleted of neutrophils by pretreatment with mechlorethamine while in others the specific platelet activating factor receptor antagonist WEB 2086 was given to the support animal before formyl-methionyl-leucyl-phenylalanine. Differential blood cell counts were determined throughout the course of each experiment. Each heart was examined histologically after the experiment.Formyl-methionyl-leucyl-phenylalanine caused a significant rise in perfusion pressure which was virtually abolished by leucocyte depletion of the support animal. The response could also be reduced by about 80% with intravenous WEB 2086. Histological examination of the perfused hearts showed that the number of accumulated neutrophils was very variable and not correlated with the rise in perfusion pressure. There was no significant difference between control hearts and those receiving WEB 2086.The results confirm previous reports that the response to formyl-methionyl-leucyl-phenylalanine is neutrophil dependent and show that this model of a blood perfused heart can be used successfully to examine the response to a leucocyte dependent stimulus. The results also suggest that the response to formyl-methionyl-leucyl-phenylalanine may not only be due to physical obstruction of the coronary circulation or "neutrophil plugging", but may also be due to the release of platelet activating factor.
Abstract 2097A: The role of Lipocalin-2 in colorectal cancer metastasis
Authors: Daniel Titus Hughes
Journal: Cancer Research (2014)

Abstract Colorectal cancer, the third leading cause of cancer deaths in America, has a poor clinical outcome once the disease has progressed to stage IV metastatic cancer. Five-year survivorship of stage IV is only 10%, but survivorship of stage I is drastically higher at 90%. Therefore, understanding the early stages of colorectal cancer metastasis is critical to develop therapeutic strategies for treating and preventing stage IV colorectal cancer. Using an orthotopic model for colorectal cancer metastasis, we have observed that our highly metastatic cell line produces a pre-metastatic upregulation of Lipocalin-2 both in circulation and in the liver. Overexpression of Lipocalin-2 in our highly metastatic cell line led to an overall reduction of circulating iron. Lipocalin-2 is upregulated in many primary tumors of epithelial origin, but the role of Lipocalin-2 in metastasis remains unclear. The full effects and implications of Lipocalin-2 in colorectal cancer metastasis remain to be elucidated. Citation Format: Daniel Titus Hughes. The role of Lipocalin-2 in colorectal cancer metastasis. [abstract]. In: Proceedings of the 105th Annual Meeting of the American Association for Cancer Research; 2014 Apr 5-9; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2014;74(19 Suppl):Abstract nr 2097A. doi:10.1158/1538-7445.AM2014-2097A
Carbenicillin Therapy for Pseudomonas Infections
Authors: Gerald P. Bodey
Journal: JAMA (1971)

Carbenicillin disodium was effective in the treatment of 91% (54) of 59 infections caused by<i>Pseudomonas</i>organisms. However, 7% (4) of the infections responded only partially, and 10% (6) relapsed when therapy was discontinued. The response rate and relapse rate did not correlate very closely with the results of in vitro sensitivity testing. Only 7% (4) of the strains of pseudomonas became resistant during carbenicillin therapy, and there has been no major increases in carbenicillin-resistant isolates at the University of Texas M. D. Anderson Hospital and Tumor Institute since the widespread usage of this antibiotic was begun. The frequency of pseudomonas as a cause of fatal infection in adults with leukemia has decreased from 31% to 8% (8 deaths) since carbenicillin has been introduced. Superinfection occurred in 17% (10) of the patients receiving this drug. Toxic effects were minimal and consisted mainly of transient elevations in serum glutamic oxaloacetic transaminase and serum glutamic pyruvic transaminase levels.
Do hot flashes explain the protective association between HRT and CAD in women: the NHLBI-sponsored WISE study
Authors: C.Noel Bairey-Merz, B.Delia Johnson, Vera Bittner, Barry L. Sharaf, Steven E. Reis, Nathaniel Reichek, William Rogers, Carl J. Pepine, George Sopko
Journal: Journal of the American College of Cardiology (2002)
The problem in setting research priorities: a layman's experience
Authors: L. Firkins
Journal: BMJ (2008)

I am a 59 year old former banker. Seven years ago I lost my 25 year old son, Ellis, to new variant Creutzfeldt-Jakob disease (CJD). Until that time I had no knowledge of or interest in clinical trials. It was because of my subsequent chairing of a CJD patients’ charity that I became involved with the world of clinical trials. This involvement took several forms:

Obviously, these were all new experiences for me. Until I learnt otherwise I took the consumer workshop—a one day event at which families and carers were brought together and asked to help set research priorities—to be normal practice. A report …
Oculo-Orogenital Syndrome — A Deficiency of Vitamins B<sub>2</sub>and B<sub>6</sub>
Authors: André Friedli, Jean-Hilaire Saurat
Journal: New England Journal of Medicine (2004)

A 48-year-old man presented with a six-month history of irritated mouth angles, irritated genital skin, and red, burning eyes. On physical examination, he had blepharoconjunctivitis (Panel A), angular stomatitis (Panel B), a bright red and atrophic tongue, and dermatitis of the pubic area (Panel C). Findings on the remainder of the examination were unremarkable. For several months, the patient had been consuming approximately 150 g of alcohol daily and large quantities of beef and pork, but hardly any cereals or vegetables. Ultrasonography showed an enlarged, fatty liver. On routine laboratory testing, the hemoglobin level was 16.4 g per deciliter, the . . .
CANCER OF STOMACH
Authors: John William Shuman
Journal: JAMA (1926)

Seldom is the opportunity given to check up on one's colleagues as closely and accurately as this case affords. The case is worth while reporting because of the lesion, the radical operation performed seventeen years prior to death, and the ease with which all facts pertaining were assembled. A man, aged 52, admitted in May, 1925, complained of loss of weight as a result of inability to take and assimilate food. From then until his death, November 23, repeated and detailed examinations failed to diagnose more than gastric malignancy. His history stated that part of the stomach was cut away and a new opening made by Dr. William Mayo, sixteen years previously. The patient had fair health until eight months before coming to the hospital. The roentgenogram showed a functioning gastro-enterostomy; about one third of the stomach, the cardiac end, could be seen. Hydrochloric acid was absent. Occult blood was
Monogenic control of variations in antipyrine metabolite formation. New polymorphism of hepatic drug oxidation.
Authors: M B Penno, E S Vesell
Journal: Journal of Clinical Investigation (1983)

To investigate mechanisms that control large variations among normal uninduced subjects in the elimination of the model compound antipyrine (AP) and other drugs, AP was administered to 144 subjects (83 unrelated adults and 61 members of 13 families). Thereafter, at regular intervals for 72 h, the urine of each subject was collected and concentrations of AP and its three main metabolites measured. From these urinary concentrations, rate constants for formation of each AP metabolite were calculated. Trimodal curves were observed when values for each AP rate constant were plotted in 83 unrelated subjects; probit plots of these values showed inflections at the two antimodes of each trimodal distribution. All members of our 13 families were assigned one of three phenotypes determined by where their AP metabolite rate constant placed them in the trimodal distributions derived from the 83 unrelated subjects. In each family, pedigree analysis to identify the mode of transmission of these three phenotypes was consistent with their monogenic control. These results provide evidence for a new polymorphism of drug oxidation in man.
Blood flow in ischaemic feet.
Authors: V C Roberts, S Sabri, L T Cotton
Journal: BMJ (1971)

and in chronic renal failure a satisfactory diuresis may be obtained.That no deafness was evident with the smaller dose suggests that the effect is dose dependent, not a sensitivity phenomenon.In view of its inconstancy from person to person, however, there clearly are other variables, such as patient idiosyncrasy or possibly degree of renal failure to consider.The phenomenon appears to be of a benign prognosis.-I am, etc.,
Folic acid-conjugated Silica-modified gold nanorods for X-ray/CT imaging-guided dual-mode radiation and photo-thermal therapy
Authors: Peng Huang, Le Bao, Chunlei Zhang, Jing Lin, Teng Luo, Dapeng Yang, Meng He, Zhiming Li, Guo Gao, Bing Gao, Shen Fu, Daxiang Cui
Journal: Biomaterials (2011)
Malaria: Host-Defense Mechanisms and Complications
Authors: FRANKLIN A. NEVA
Journal: Annals of Internal Medicine (1970)

The importance of specific diagnosis needs emphasis in relation to the increased prevalence of malaria at civilian medical facilities in the United States. In considering host-defense mechanisms the most striking feature of malaria is generalized stimulation of the reticuloendothelial system, including synthesis of humoral antibody. The activity of various components of the defense system may be responsible for some characteristic features of malaria as well as for certain complications. For example, the temporal relationship of maximum parasitemia, first appearance of humoral antibody, and transient fall in complement all suggest that the concomitant thrombocytopenia may be related to some immunologic mechanism. In less severe forms of simian or human malaria no evidence for a process of disseminated intravascular coagulation was found. Two case reports illustrate the complications of severe Plasmodium falciparum malaria—namely renal failure, cerebral malaria, and pulmonary edema or hemorrhage. The present status of chemotherapy of falciparum infections is reviewed.
Specificity of Treadmill Stress Test
Authors: MARTIN JEFFREY FRANK
Journal: Annals of Internal Medicine (1976)

Comments1 December 1976Specificity of Treadmill Stress TestMARTIN JEFFREY FRANK, M.D.MARTIN JEFFREY FRANK, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-85-6-826_1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: The recent paper by Goldschlager, Selzer, and Cohn, "Treadmill Stress Tests as Indicators of Presence and Severity of Coronary Artery Disease" (Ann Intern Med 85:277-286, 1976), provides much worthwhile information. However, the method for calculating specificity is disturbing. In the total of 141 "true negative" patients, there are 80 "healthy male volunteers" who did not undergo coronary arteriography. How can these patients be "truly negative" without angiographic confirmation? If these patients are not used for calculation of specificity, the figures of 93% (flat downsloping ST segments) and 82% (slowly upsloping ST segments included) will be significantly lower.... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Department of Cardiology Yater Clinic 1780 Massachusetts Ave., N.W. Washington, D.C. 20036 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 December 1976Volume 85, Issue 6Page: 826-826KeywordsAngiographySpecificityStable coronary artery disease Issue Published: 1 December 1976 PDF downloadLoading ...
Surgery in America: From the Colonial Era to the Twentieth Century
Authors: Irwin M. Siegel
Journal: JAMA (1984)

Medical histories tend to follow several formats. They are either biographical catalogues, historical narratives, or a loosely connected collection of essays or memoirs. Dr Earle has styled his anthology differently, presenting the story of American surgery, "in the words of those who practiced in the past and knew the surgery of their times." This second, expanded edition of his book includes, "selections from texts, lectures, or articles that shaped the practice and philosophy of American surgery." Items were chosen "that give a feeling both for surgery as it was practiced and for the time in which the piece was written." Each selection is prefaced by a biographical sketch. Sixty illustrations, including many portraits of the surgeon authors, complement the text, and exacting notes are provided for each chapter. The book begins with the first published description of a surgical procedure performed in an American colony (around 1640), "Abigail Eliot's Head
Densitometry of the Peripheral Skeleton to Detect Osteopenia-Reply
Authors: R. B. Mazess
Journal: JAMA (1986)

<h3>In Reply.—</h3> Dr Bilbrey alleges that there is evidence that the distal radius provides an early indication of osteopenia useful for diagnosis of osteoporosis. He presumes that this is due to a higher trabecular content at a "5-mm" radius site used in the Beta Diagnostics clinics. The 5-mm site is located at from 5% to 10% of theforearm length, where there is only 35% trabecular bone, not more than 50% as claimed.<sup>1</sup>The trabecular content is immaterial however, since even purely trabecular bone of the distal radius (1) is poorly correlated with that of the axial skeleton,<sup>2,3</sup>(2) has an onset of bone loss a decade after that in the spine and the femur, (3) has a low rate of aging bone loss,<sup>3,4</sup>and (4) does not respond to various therapies used for osteoporosis.<sup>5,6</sup> Peripheral measurements could be clinically useful if they predicted bone density
Reexpansion Pulmonary Edema after Treatment of Pneumothorax
Authors: Syed Mohammad Tariq, Tabinda Sadaf
Journal: New England Journal of Medicine (2006)

A 50-year-old smoker presented with acute-onset breathlessness and right-sided chest pain of four days' duration. There was no history of chest trauma. A posteroanterior chest radiograph (Panel A) demonstrated a right-sided pneumothorax. His symptoms improved immediately on placement of a chest tube. Two hours later, he again became breathless, and examination revealed extensive right-sided chest crackles. Chest radiography was repeated and showed a fully expanded right lung (Panel B), albeit with features of pulmonary edema. The arrowheads in Panel B show the position of the chest tube. The patient's condition improved after continuous positive airway pressure was delivered through a . . .
Promoting primary care: where to start?
Authors: R. D. Gillette
Journal: JAMA (1993)

To the Editor.  —Stimmel's 1 otherwise excellent Special Communication on primary care perpetuates the myth that the professional demands on primary physicians are inevitably more burdensome and their life-styles necessarily less desirable than those of other specialists. It is true that there is little need for night and weekend services in such limited fields as dermatology and pathology and that emergency physicians provide around-the-clock service by working in shifts. However, patients in most clinical specialties may require care at any hour of the day or night, and off-hours care is typically provided by residents, salaried hospital-based physicians, and members of physician groups taking call in rotation. These strategies are equally available to family physicians and other primary care specialists.  It is also untrue that primary physicians typically work longer hours than their colleagues in other disciplines. Available data indicate that the former fall in the middle of the range of