THALASSEMIA IN "NON-MEDITERRANEAN" FAMILIES
Authors: William Mcfarland, Howard A. Pearson
Journal: Annals of Internal Medicine (1960)

Article1 September 1960THALASSEMIA IN "NON-MEDITERRANEAN" FAMILIESWILLIAM MCFARLAND, HOWARD A. PEARSONWILLIAM MCFARLANDSearch for more papers by this author, HOWARD A. PEARSONSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-53-3-510 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptIn 1925 and 1927 Cooley and Lee1, 2 described an anemia peculiar to individuals of Greek or Italian origin. Subsequently, the disease has been so thoroughly studied and documented that thalassemia is one of the first diagnostic considerations in an individual of "Mediterranean background" who presents with hypochromic anemia. However, the disease is rarely entertained as a diagnostic possibility in the absence of such an ethnic background, in spite of the fact that there have been numerous reports of the disease in other racial groups in almost all parts of the world.One reason for hesitancy to diagnose thalassemia in...Bibliography1. CooleyLee TBP: A series of cases of splenomegaly in children, with anemia and peculiar bone changes, Tr. Am. Pediat. Soc. 37: 29, 1925. Google Scholar2. CooleyWitwerLee TBERP: Anemia in children with splenomegaly and peculiar changes in bones: report of cases, Am. J. Dis. Child. 34: 347, 1927. CrossrefGoogle Scholar3. Dacie JV: The haemolytic anemias, 1954, Grune and Stratton, New York, p. 536. Google Scholar4. MossMellon MLMG: Colorimetric determinations of iron with 2, 21 bipyridyl and with 2, 21 211 terpyridyl, Indust. and Eng. Chem., Anal. Ed. 14: 862, 1942. CrossrefGoogle Scholar5. SingerChernoffSinger KAIL: Studies on abnormal hemoglobins. I. Their demonstration in sickle cell anemia and other hematologic disorders by means of alkali denaturation, Blood 6: 413, 1951. CrossrefMedlineGoogle Scholar6. PearsonMcFarland HAW: Starch block electrophoresis of hemoglobin, U. S. Armed Forces M. J. 10: 693, 1959. MedlineGoogle Scholar7. MitchellSpencerKing TGRPER: The use of radioisotopes in diagnostic hematologic procedures. III. Simultaneous Cr51 and Fe59 studies, Am. J. Clin. Path. 28: 461, 1957. CrossrefMedlineGoogle Scholar8. Neel JV: The detection of the genetic carriers of hereditary disease, Am. J. Human Genet. 1: 19, 1949. MedlineGoogle Scholar9. SmithSissonFloydSiegel CHTRWHS: Serum iron and iron-binding capacity of the serum in children with severe Mediterranean (Cooley's) anemia, Pediatrics 5: 799, 1950. MedlineGoogle Scholar10. GeraldDiamond PSLK: The diagnosis of thalassemia trait by starch block electrophoresis of the hemoglobin, Blood 13: 61, 1958. CrossrefMedlineGoogle Scholar11. PearsonMcFarland HAW: Erythrokinetics in thalassemia trait, J. Lab. and Clin. Med., in press. Google Scholar12. SturgeonFinch PCA: Erythrokinetics in Cooley's anemia, Blood 12: 64, 1957. CrossrefMedlineGoogle Scholar13. KunkelWallenius HGG: New hemoglobin in normal adult blood, Science 122: 288, 1955. CrossrefMedlineGoogle Scholar14. RhinesmithSchroederPauling HSWAL: A quantitative study of the hydrolysis of human dinitrophenyl (DNP) globin: the number and kind of polypeptide chains in normal adult human hemoglobin, J. Am. Chem. Soc. 79: 4682, 1957. CrossrefGoogle Scholar15. ItanoSinger HASJ: On dissociation and recombination of human adult hemoglobins A, S and C, Proc. Nat. Acad. Sc. 44: 522, 1958. CrossrefMedlineGoogle Scholar16. ItanoRobinson HAE: Properties and inheritance of haemoglobin by asymmetric recombination, Nature, London 184: 1468, 1959. CrossrefMedlineGoogle Scholar17. IngramStretton VMAO: Genetic basis of the thalassaemia diseases, Nature, London 184: 1903, 1959. CrossrefMedlineGoogle Scholar18. Cooley TB: Hereditary factors in the blood dyscrasias (President's address), Am. J. Dis. Child. 62: 1, 1941. CrossrefGoogle Scholar19. Allison AC: Protection afforded by sickle-cell trait against subtertian malarial infection, Brit. M. J. 1: 290, 1954. CrossrefMedlineGoogle Scholar20. MinnichNa-NakornChongchareonsukKochaseni VSSS: Mediterranean anemia. A study of thirty-two cases in Thailand, Blood 9:1, 1954. CrossrefMedlineGoogle Scholar21. SiddooSiddooChaseMorgan-DeanPerry JKSKWHLWH: Thalassemia in Sikhs, Blood 11: 197, 1956. CrossrefMedlineGoogle Scholar22. MatothShamirFreundlich YZE: Thalassemia in Jews from Kurdistan, Blood 10: 176, 1955. CrossrefMedlineGoogle Scholar23. Third, fourth and fifth reports of the Committee for Clarification of the Nomenclature of Cells and Diseases of the Blood and Blood-forming Organs, Am. J. Clin. Path. 20: 562, 1950. CrossrefMedlineGoogle Scholar24. Dameshek W: "Thalassemia," or what's in a name, Editorial, Blood 10: 293, 1955. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Bethesda, Maryland*Received for publication May 17, 1960.Presented at the Forty-first Annual Session of The American College of Physicians, San Francisco, California, April 7, 1960.From the U. S. Naval Hospital, National Naval Medical Center, Bethesda, Maryland.Requests for reprints should be addressed to William McFarland, M.D., U. S. Naval Hospital, Bethesda 14, Maryland. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byProlonged Survival in Homozygous High A2-Type Beta ThalassaemiaALPHA- AND BETA-THALASSEMIA IN THAILANDHAEMOGLOBIN J BALTIMORE INTERACTING WITH BETA‐THALASSAEMIA IN AN AUSTRALIAN FAMILYTHALASSAEMIA MINOR IN AUSTRALIANS OF NORTHERN EUROPEAN EXTRACTION: A REPORT OF FIVE FAMILIESThalassemia Intermedia: Genetic and Biochemical ConsiderationsTHALASSÆMIA IN PEOPLE OF BRITISH STOCKThalassaemia in ScotsNewer Concepts in the Genetics of the ThalassemiasMedical genetics 1960 1 September 1960Volume 53, Issue 3Page: 510-522KeywordsAnemiaBeta-thalassemiaHemoglobinThalassemia ePublished: 1 December 2008 Issue Published: 1 September 1960 PDF downloadLoading ...