THE TOXICITY OF 2-HYDROXYSTILBAMIDINE: PROBABLE FATAL TOXIC REACTION DURING TREATMENT OF BLASTOMYCOSIS
Authors: J W OBERMAN, E F GILBERT
Journal: Annals of Internal Medicine (1958)

Case Reports1 June 1958THE TOXICITY OF 2-HYDROXYSTILBAMIDINE: PROBABLE FATAL TOXIC REACTION DURING TREATMENT OF BLASTOMYCOSISJ. WILLIAM OBERMAN, M.D., ENID F. GILBERT, M.D.J. WILLIAM OBERMAN, M.D.Search for more papers by this author, ENID F. GILBERT, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-48-6-1401 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptFollowing the original report of Schoenbach et al.1of the successful therapy of a case of systemic North American blastomycosis treated with the aromatic diamidine, stilbamidine, numerous publications have attested to the efficacy of this drug in the treatment of blastomycosis and other mycotic infections.2-10Due, however, to the high incidence of trigeminal neuropathy in patients receiving stilbamidine, it is frequently necessary to discontinue the drug before a full therapeutic effect is attained.2, 5, 11-13More recently, other reports of the successful use of a stilbamidine derivative, 2-hydroxystilbamidine, in the therapy of these diseases have appeared.5, 10, 14-17No serious...Bibliography1. 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New York Acad. Med. 26: 269, 1950. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: *Received for publication October 16, 1956.From The Departments of Pediatrics and Pathology, The Children's Hospital of The District of Columbia, Washington, D. C.Requests for reprints should be addressed to J. William Oberman, M. D., Children's Hospital of the District of Columbia, 2125 Thirteenth Street, Northwest, Washington 9, D. C. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byIntracranial injection of Fluoro-Gold results in the degeneration of local but not retrogradely labeled neuronsHydroxystilbamidineBlastomycosis in children: A review of the literatureTHE AROMATIC DIAMIDINESBlastomycosis in childhood: treatment with amphotericin B and a review of the literatureHeart muscle diseaseSynergism between specific immune globulin and antibiotics in therapy of experimental blastomycosisDie Antimykotica 1 June 1958Volume 48, Issue 6Page: 1401-1414KeywordsAutopsy pathologyBlastomycosisChildrenDrug therapyNauseaNeuropathyPediatric infectionsPediatricsSystemic diseasesToxicity ePublished: 1 December 2008 Issue Published: 1 June 1958 PDF downloadLoading ...