Hypovolemic Shock and Hypotension as a Complication in the Nephrotic Syndrome
Authors: HIROSHI YAMAUCHI
Journal: Annals of Internal Medicine (1964)

Article1 February 1964Hypovolemic Shock and Hypotension as a Complication in the Nephrotic SyndromeReport of Ten CasesHIROSHI YAMAUCHI, M.D., JAMES HOPPER JR., M.D.HIROSHI YAMAUCHI, M.D.Search for more papers by this author, JAMES HOPPER JR., M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-60-2-242 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptClinical descriptions of circulatory insufficiency in the nephrotic syndrome are few despite the established observation that a reduction in blood volume is found in this disease state (1-15). According to Squire (13), total blood volume in patients with the nephrotic syndrome may be decreased to 70 to 80 per cent of normal. Acute decreases in blood volume of this magnitude in other clinical situations have often been associated with shock or hypotension (16-21).Between 1944 and 1960, we have seen the occurrence of shock or hypotension in 10 adult patients with the nephrotic syndrome. The patients were studied during periods...References1. PLESCH J: Hämodynamische Studien. Z. Exp. Path. Ther. 6: 380, 1909. CrossrefGoogle Scholar2. LINDERLUNDSGAARDVAN SLYKESTILLMAN GCCDDE: Changes in the volume of plasma and absolute amount of plasma proteins in nephritis. J. Exp. Med. 39: 921, 1924. CrossrefMedlineGoogle Scholar3. BROWNROWNTREE GELG: The volume and composition of the blood, and the changes incident to diuresis, in cases of edema. Arch. Intern. Med. (Chicago) 35: 129, 1925. CrossrefGoogle Scholar4. DARROW DC: The blood volume in cases of nephritis with edema and low serum protein concentration. Proc. Soc. Exp. Biol. Med. 23: 740, 1926. CrossrefGoogle Scholar5. 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Author, Article, and Disclosure InformationAuthors: HIROSHI YAMAUCHI, M.D.; JAMES HOPPERJR., M.D.Affiliations: San Francisco, CaliforniaFrom the Department of Medicine, University of California School of Medicine, San Francisco, California.This work was supported by grant H-1271 from the United States Public Health Service, Bethesda, Maryland, and by funds allocated by the Committee on Research of the University of California School of Medicine, San Francisco, California.Requests for reprints should be addressed to Editorial Office (Yl), Department of Medicine, University of California Medical Center, San Francisco 22, California.Dr. Yamauchi is a Captain in the Medical Corps of the United States Air Force, and the opinions expressed are those of the authors and in no way reflect the official views of the United States Air Force. 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