THE USE OF DILATIN IN THE TREATMENT OF EPILEPSY
Authors: O. P. Kimball, T. N. Horan
Journal: Annals of Internal Medicine (1939)

Article1 November 1939THE USE OF DILATIN IN THE TREATMENT OF EPILEPSYO. P. KIMBALL, M.D., F.A.C.P., T. N. HORAN, M.D., F.A.C.P.O. P. KIMBALL, M.D., F.A.C.P.Search for more papers by this author, T. N. HORAN, M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-13-5-787 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe drug diphenyl-hydantoin has been known for several years but it was so nearly insoluble that it was considered practically useless. In 1937 the sodium salt of this compound was prepared in the Parke-Davis Laboratories and this drug (sodium-diphenyl-hydantoinate) was studied for anticonvulsant properties by Merritt and Putnum of Boston.1Because of its promise as an anticonvulsant, thorough pharmacological studies were made. Animal experimentation showed it to be practically non-toxic and to have little or no hypnotic effect. The method of excretion and end products could not be determined. From observation it was believed that there was no tendency toward...References1. MERRITTPUTNUM HHTJ: Sodium diphenyl-hydantoinate in the treatment of convulsive disorders, Jr. Am. Med. Assoc., 1938, cxi, 1068. CrossrefGoogle Scholar2. KIMBALL OP: The treatment of epilepsy with sodium diphenyl-hydantoinate, Jr. Am. Med. Assoc., 1939, cxii, 1244. CrossrefGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: *Received for publication May 11, 1939. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byTopical phenytoin effects on palatal wound healingOutcomes of topical phenytoin in the management of traumatic woundsPalliative Wound CarePhenytoin repositioned in wound healing: clinical experience spanning 60 yearsPhenytoin: a step by step insight into its multiple mechanisms of action—80 years of mechanistic studies in neuropharmacologyTRPA1 Channels Mediate Human Gingival Fibroblast Response to PhenytoinTopical phenytoin for treating pressure ulcersA Comparative Study of Honey and Phenytoin Dressings for Chronic WoundsASSESSMENT OF EFFICACY OF TOPICAL PHENYTOIN SODIUM DRESSING AS COMPARED TO CONVENTIONAL MOIST DRESSING IN THE MANAGEMENT OF LEG ULCERSTrophic skin ulceration in leprosy: evaluation of the efficacy of topical phenytoin sodium zinc oxide pasteProperties of Wound Healing Activities of Rosemary ExtractThe use of topical phenytoin for healing of chronic venous ulcerationsEvaluation of Wound Healing Effect of Topical Phenytoin on Excisional Wound in Albino RatsA Visit to the Borderland of Neurology and PsychiatryTopical Phenytoin Treatment in Bimaxillary Osteomyelitis Secondary to Infantile Osteopetrosis: Report of a CaseGlycosaminoglycans in Enlarged Gingiva Induced by NifedipineRole of phenytoin in healing of large abscess cavitiesEffect of Sodium Diphenylhydantoin on Skin Wound Healing in RatsChanges in extracellular matrix macromolecules in human gingiva after treatment with drugs inducing gingival overgrowthIncidence and severity of phenytoin-induced gingival overgrowth in epileptic patients in General Medical PracticeEffect of cell donor age on the synthetic properties of fibroblasts obtained from phenytoin-induced gingival hyperplasiaPresentations of acute phenytoin overdoseA defect in fibroblasts from an unidentified syndrome with gingival hyperplasia as the predominant featureNecrotizing vasculitis associated with diphenylhydantoin: Two fatal casesQuantitative histopathologic assessment of developing phenytoin-induced gingival overgrowth in the catEffects of phenytoin on [3H]diazepam binding in dissociated primary cortical cell cultureAntihistaminic Therapy for Gingival Hyperplasia Due to DilantinSuicidal Dilantin (Sodium Diphenylhydantoin) PoisoningDilantin SensitivityGingival Biopsy: A New Technic for Diagnosis of Generalized AmyloidosisCase report: Progressive malocclusion associated with dilantin therapyAnalysis of Oral Reactions to Dilantin-SodiumThe treatment of epilepsy with sodium diphenyl hydantoinateThe Modern Treatment of Epilepsy 1 November 1939Volume 13, Issue 5Page: 787-793KeywordsAnticonvulsantsDrugsEpilepsyExcretionSaltsSodium ePublished: 1 December 2008 Issue Published: 1 November 1939 PDF downloadLoading ...