Anti-Rhesus Antibodies, Immune Thrombocytopenia, and Human Immunodeficiency Virus Infection
Authors: Philippe Bierling, Georges Karianakis, Najib Duedari, Christian Desaint, Eric Oksenhendler, Bahman Habibi, Yves Brossard
Journal: Annals of Internal Medicine (1987)

Letters and Corrections1 May 1987Anti-Rhesus Antibodies, Immune Thrombocytopenia, and Human Immunodeficiency Virus InfectionPHILIPPE BIERLING, M.D., GEORGES KARIANAKIS, M.D., NAJIB DUEDARI, M.D., CHRISTIAN DESAINT, M.D., ERIC OKSENHENDLER, M.D., BAHMAN HABIBI, M.D., YVES BROSSARD, M.D.PHILIPPE BIERLING, M.D.Search for more papers by this author, GEORGES KARIANAKIS, M.D.Search for more papers by this author, NAJIB DUEDARI, M.D.Search for more papers by this author, CHRISTIAN DESAINT, M.D.Search for more papers by this author, ERIC OKSENHENDLER, M.D.Search for more papers by this author, BAHMAN HABIBI, M.D.Search for more papers by this author, YVES BROSSARD, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-106-5-773_3 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: Treatment with intravenous anti-D (rhesus) immunoglobulins has been reported to be effective and safe in patients with immune thrombocytopenia (1). The mechanism of this treatment remains controversial (1, 2). Due to the risk of using corticosteroids in carriers of the human immunodeficiency virus (HIV) (3, 4), a therapeutic trial using immunoglobulins for various rhesus antigens has been done in HIV carriers with immune thrombocytopenia and bleeding. We report the treatment results in two patients, showing that the platelet increment requires the interaction between erythrocyte antigens and their specific antibodies.A 27-year-old homosexual man (body weight, 65 kg)...References1. SALAMAMUELLER-ECKHARDTKIEFEL ACV. Effect of intravenous immunoglobulin in immune thrombocytopenia. Lancet. 1983;2:193-5. CrossrefMedlineGoogle Scholar2. CONTRERASMOLLISON MP. Anti-Rh(D) immunoglobulin for immune thrombocytopenic purpura. Lancet. 1986;2:49-50. CrossrefMedlineGoogle Scholar3. OKSENHENDLERBIERLINGCLAUVELFARCETRABIANSELIGMANN EPJJCM. Chronic auto-immune thrombocytopenic purpura in LAV seropositive patients: response to therapy [Abstract]. In: Proceedings of the Second International Conference on AIDS, Paris. 1986:47. Google Scholar4. SHAFEROFFITMACRISHORBARANCONAHOFFMAN RKNBLI. Possible risk of steroid administration in patients at risk for AIDS [Letter]. Lancet. 1985;1:934-5. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byABO blood groups and risk of human immunodeficiency virus infection: A systematic review and meta‐analysisIntravenous Immunoglobulin for Autoimmune Thrombocytopenic PurpuraIntravenous immunoglobulin and autoimmune thrombocytopenic purpura: 22 years onThe Treatment of Patients with Autoimmune Thrombocytopenia with Intravenous IgG-Anti-DReplyUse of Rh Antibodies in the Treatment of Autoimmune ThrombocytopeniaThe treatment of autoimmune thrombocytopaenic purpura with anti-D immunoglobulin: similar platelet responses in homozygous and heterozygous Rh(D) positive patientsEfficacité de l'azidothymidine sur la thrombopénie associée à l'infection par le virus HIVHuman immunodeficiency virus-associated autoimmune thrombocytopenic purpura: A review 1 May 1987Volume 106, Issue 5Page: 773-774KeywordsAntibodiesAntigensBody weightCorticosteroid therapyHIVHemorrhageHomosexualsIdiopathic thrombocytopenic purpuraPlateletsRhesus Issue Published: 1 May 1987 PDF downloadLoading ...