ARSENICAL SENSITIVITY AND VITAMIN C
Authors: Mahlon H. Delp, C. J. Weber
Journal: Annals of Internal Medicine (1941)

Article1 November 1941ARSENICAL SENSITIVITY AND VITAMIN CMAHLON H. DELP, M.D., C. J. WEBER, M.D.MAHLON H. DELP, M.D.Search for more papers by this author, C. J. WEBER, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-15-5-890 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptWith the advent of arsenic as a spirochetocide, the physician found that one of his great problems in handling the syphilitic patient was that of avoiding, if possible, the toxic manifestations of this therapeutic agent, or of treating them if they appeared. Numerous improvements in arsenical preparations and improvements in the technic of their administration have not yet eliminated these problems. Toxic manifestations take many forms—from the milder gastrointestinal disturbances to the severe hemorrhagic encephalitis—with the intermediate complications of hepatitis, purpura, and arsenical dermatitis occurring all too frequently. In a large antisyphilitic clinic, constant and individual attention must be given...Bibliography1. CHAPMANMORRELL CWCA: Influence of vitamin C on the development of skin sensitivity to neoarsphenamine in the guinea pig, Proc. Soc. Exper. Biol. and Med., 1935, xxxii, 813-815. CrossrefGoogle Scholar2. SULZBERGEROSER MBBL: The influence of ascorbic acid of diet on sensitization of guinea pigs to neoarsphenamine, Proc. Soc. Exper. Biol. and Med., 1935, xxxii, 716-719. CrossrefGoogle Scholar3. CORMIA FE: Experimental arsphenamine dermatitis—the influence of vitamin C in the production of arsphenamine sensitiveness, Canad. Med. Assoc. Jr., 1937, xxxvi, 392-396. Google Scholar4. DAINOW I: Desensitization action of l-ascorbic acid, Ann. Dermat. and Syph., 1935, vi, 830. Google Scholar5. LANDFISCH S: Redoxon in prophylaxis of arsphenamine accidents, Polska. gas. lek., 1937, xvi, 575-577. Synthetic cevitamic acid—new auxiliary remedy in arsphenamine therapy, Jr. Am. Med. Assoc., 1937, cix, 834. Google Scholar6. LEVERTALBOTT WFJH: Role of vitamin C in various cutaneous diseases, Arch. Dermat. and Syph., 1940, xli, 657-663. CrossrefGoogle Scholar7. MINDLINBUTLER RLAM: Determination of ascorbic acid in plasma. Macromethod and micromethod, Jr. Biol. Chem., 1938, cxxii, 673-686. CrossrefGoogle Scholar8. FRIENDMARQUIS DGHH: Arsphenamine sensitivity and vitamin C, Am. Jr. Syph., Gonor. and Ven. Dis., 1938, xxii, 239-242. Google Scholar9. CROFTSNORF JDLD: Cevitamic acid deficiency frequency in a group of 100 unselected patients, Am. Jr. Med. Sci., 1939, cxcviii, 403-408. CrossrefGoogle Scholar10. FARMERABTARONS CJAFHC: Influence of arsenicals, bismuth and iron on plasma ascorbic acid level, Proc. Soc. Exper. Biol. and Med., 1940, xliv, 495-499. CrossrefGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Kansas City, Kansas*Received for publication December 5, 1940.From the Department of Internal Medicine and Hixon Laboratory for Medical Research, University of Kansas School of Medicine, Kansas City, Kansas. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byDer Bedarf an Vitamin C bei Bleiarbeitern 1 November 1941Volume 15, Issue 5Page: 890-898KeywordsArsenicHepatitisResearch laboratoriesVitamin C ePublished: 1 December 2008 Issue Published: 1 November 1941 PDF downloadLoading ...