tbuckley/cabot-search huggingface dataset:
Trends in Cardiovascular Complications of Diabetes—Reply
Authors: Caroline S. Fox, Paul D. Sorlie, Peter J. Savage
Journal: JAMA (2005)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
University sues scientist for £400000 for undeclared fees
Authors: Clare Dyer
Journal: BMJ (2000)

Simon Fishel, one of Britain's leading infertility experts, is being sued for£400000 ($640000) by his former employers, Nottingham University, which alleges that he earned substantial “secret profits” from treating private patients abroad using university staff and facilities.

The case, in its second week of trial in the High Court in London, has implications for academic staff who top up their salaries by doing private work.

Legal costs are thought to have reached £500000 before the case reached trial, and Dr Fishel, who has taken out a second mortgage on his …
Hospitals take short term measures to meet targets
Authors: Susan Mayor
Journal: BMJ (2003)

Two thirds of accident and emergency (A&E) departments in England put in place temporary measures during a recent monitoring week so that they appeared to meet the government's waiting time target of four hours, a BMA survey has found.

Preliminary results from the first 100 A&E consultants from a total of 500 who were sent a questionnaire showed that more than half (56%) had used temporary medical and nursing agency staff to reduce patient waiting times during the monitoring week. One in four consultants (25%) reported that their departments had allowed staff to work double or extended shifts at this time.

Nearly one in six (14%) survey respondents said that routine surgery had been cancelled …
Impact of Major Adverse Cardiac Events and Major Bleeding on Overall Mortality in Patients with Acute Myocardial Infarction: Results from the HORIZONS-AMI Trial
Authors: H Parise, R Mehran, B Witzenbichler, G Guagliumi, JZ Peruga, BR Brodie, D Dudek, R Kornowski, F Hartmann, BJ Gersh, SJ Pocock, G Dangas, SC Wong, A Kirtane, AJ Lansky, GW Stone
Journal: Circulation (2008)
Two Distinct Mechanisms of Antitumor Activity Mediated by the Combination of Interleukin 2 and Monoclonal Antibodies
Authors: Vuist Wm, van Buitenen F, Hekman A, Melief Cj
Journal: Cancer Research (1990)

Previously we described a human B-lymphoma xenotransplantation model in which the immunotherapeutic activity of monoclonal antibodies (mAbs), directed against human B-cell antigens, can be studied. An anti-CD19 mAb of IgG2a subclass was therapeutically active by itself in this model, and its efficacy was increased by simultaneous administration of recombinant interleukin 2 (rIL-2). Immunotherapy with IgG1 or IgG2b isotype variants of an anti-CD19 mAb was ineffective if given alone. We now show that the combination of these ineffective isotype variants with rIL-2 results in significant antitumor effects, although IgG2a anti-CD19 mAb in combination with rIL-2 was therapeutically more active. In vitro studies of the effector mechanisms possibly involved in these treatment modalities indicate that the antitumor activity of IgG1 or IgG2b anti-CD19 mAbs in combination with rIL-2 may be mediated by rIL-2-induced antibody-dependent cellular cytotoxic activity of lymphocytes. The antitumor effect of IgG2a anti-CD19 mAb in combination with rIL-2 may be mediated not only by rIL-2-induced antibody-dependent cellular cytotoxic activity of lymphocytes but also by IgG2a-restricted antitumor activity of monocytes/macrophages. These results may explain the greater in vivo efficacy of treatment with rIL-2 and IgG2a subclass mAb versus treatment with rIL-2 and IgG1 or IgG2b subclass mAbs.
Regular review: Treatment of chronic hepatitis
Authors: P. J Gow, D. Mutimer
Journal: BMJ (2001)

Viral hepatitis is the major cause of chronic liver disease worldwide. An estimated 300 million people are carriers of the hepatitis B virus, and 120 million are infected with hepatitis C. Untreated, these infections may progress to cirrhosis, liver failure, and hepatoma. Public health measures to limit new infection, including immunisation against hepatitis B and screening of blood products for hepatitis B and C viruses, have now been implemented in most developed countries and are being implemented in many developing counties.

This review focuses on the treatment of chronic hepatitis B and C, which has undergone dramatic improvement in the past few years.

#### Summary points

Lamivudine is a safe effective antiviral drug for treating chronic hepatitis B virus infection

Lamivudine is most effective in patients with substantially elevated transaminase concentrations and those with advanced cirrhosis

Lamivudine treatment is hampered by the frequent development of resistance; in the near future combinations of antiviral agents may become standard treatment

Ribavirin in combination with interferon is effective for selected patients with chronic hepatitis C virus infection

Overall, about 30-40% of all patients can expect to be cured by this treatment, and in selected subgroups of patients cure rates of 80-90% can be achieved

Treatment with interferon alfa (as part of combination therapy) reduces the risk of developing hepatocellular carcinoma and may partially reverse hepatic fibrosis

The information used in the preparation of this article was based on a Medline search to identify key papers in addition to searching abstracts from the meetings of the American Association for the Study of Liver Disease and European Association for the Study of the Liver between 1997 and 2001. Search terms included hepatitis B virus, hepatitis C virus, treatment, lamivudine, tribavirin (ribavirin), interferon, pegylated interferon, and combination therapy.

Of the world's 300 million people with chronic hepatitis B, most …
Combinatorial polymer matrices enhance in vitro maturation of human induced pluripotent stem cell-derived cardiomyocytes
Authors: Young Wook Chun, Daniel A Balikov, Tromondae K Feaster, Charles H Williams, Calvin C Sheng, Jung-Bok Lee, Timothy C Boire, M Diana Neely, Leon M Bellan, Kevin C Ess, Aaron B Bowman, Hak-Joon Sung, Charles C Hong
Journal: Biomaterials (2015)
Vascular Pericytes Sustain Hematopoietic Stem Cells
Authors: Mirko Corselli, Chintan Parekh, Elisa Giovanna Angela Montelatici, Arineh Sahghian, Wenyuan Wang, Shundi Ge, Jessica Scholes, Felicia Codrea, Lorenza Lazzari, Gay M. Crooks, Bruno Peault
Journal: Blood (2011)
Abstract 5636: Major Depression is Associated with Decreased Coronary Flow Reserve Detected by Positron Emission Tomography
Authors: Viola Vaccarino, J D Bremner, John Votaw, Tracy Faber, Emir Veledar, Nancy V Murrah, Linda Jones, Jun Dai, Jinying Zhao, Shaoyong Su, Jack Goldberg
Journal: Circulation (2008)

Introduction. Major depressive disorder (MDD) is associated with coronary heart disease, but the underlying mechanisms are unclear. Coronary flow reserve (CFR) in response to adenosine is an index of coronary microvascular dysfunction which predisposes to myocardial ischemia. We examined the relationship between MDD and CFR in a genetically informative sample. Methods. We studied 141 twin pairs drawn from the Vietnam Era Twin Registry who were born between 1946 and 1956 (mean age 54). For all twins, a lifetime history of MDD was determined with the Structured Clinical Interview for Psychiatry Disorders; 53 pairs were discordant for MDD and 88 pairs were free of MDD. Standard cardiovascular risk factors were obtained by interview and examination. We performed myocardial perfusion imaging and blood flow quantitation with [13N] ammonia positron emission tomography at rest and after adenosine stress. A perfusion defect score summed the number and severity of defects across 20 myocardial regions. CFR was measured as the ratio of maximum flow to baseline flow at rest. Mixed-effect and GEE models were used to conduct matched-pair analyses. Results. There was no difference in the distribution of abnormal scans, in summed rest or stress defect scores, and in heart rate/blood pressure responses to adenosine between twins with and without MDD. Among the DZ twin pairs discordant for MDD, the mean CFR was lower in twins with MDD than their brothers without MDD (2.36 ± 0.66 vs 2.75 ± 0.90; p=0.03); no significant difference in mean CFR was found in MZ discordant pairs (2.90±0.78 vs 2.64±0.64, p=0.13). The zygosity by MDD interaction was significant (p=0.01). Results did not change substantially after adjusting for cardiovascular disease risk factors and antidepressant use (adjusted interaction p=0.007). There were no differences in myocardial perfusion comparing twins in discordant pairs with twins in healthy pairs. Conclusions. MDD is associated with lower CFR in spite of no differences in visible perfusion defects, suggesting microvascular dysfunction. This association is largely due to shared genetic liability between depression and CFR, suggesting a common underlying pathophysiological process linking depression and coronary microvascular dysfunction. This research has received full or partial funding support from the American Heart Association, AHA National Center.
Lack of macrophage fatty-acid–binding protein aP2 protects mice deficient in apolipoprotein E against atherosclerosis
Authors: Liza Makowski, Jeffrey B. Boord, Kazuhisa Maeda, Vladimir R. Babaev, K. Teoman Uysal, Maureen A. Morgan, Rex A. Parker, Jill Suttles, Sergio Fazio, Gökhan S. Hotamisligil, MacRae F. Linton
Journal: Nature Medicine (2001)
Color Atlas of Pediatric Dermatology.
Authors: Samuel Weinberg, Neil S. Prose, Leonard Kristal
Journal: Annals of Internal Medicine (1975)

Benign neonatal dermatoses milia, milaria and pustular and acneiform disorders bacterial infections spirochetal, protozoal and mycobacterial diseases viral and Rickettsial diseases fungal infections bites and infestations allergic, eczematous, irritant and light-related dermatoses papulosquamous, lichenoid and perforating disorders nutritional and metabolic disorders genodermatoses ichthyoses and disorders of keratinization urticarial, purpuric and vascular reactions bullous, pustular and ulcerating diseases cutaneous manifestations of systemic diseases cutaneous manifestations of HIV infection disorders of the dermis (infiltrates, atropies and nodules) drug eruptions panniculopathies vascular and lymphatic dysplasias neoplastic diseases adenexal dysplasias benign and malignant pigmented lesions miscellaneous pigmentary disorders artifacts disorders of nails and hair miscellaneous anomalies.
90. Evaluation of Novel Gene Transfer Vectors Derived from Infectious Molecular Clones of Primate AAVs
Authors: Xiaoyang Zhou, Guangping Gao, Roland A. Owens, Roberto Calcedo, James M. Wilson
Journal: Molecular Therapy (2004)

We recently isolated and characterized a diverse array of novel primate AAVs from human and nonhuman primate (NHP) tissues through either PCR-based molecular rescue of proviral sequences or direct rescue and cloning of infectious virus genomes from tissues or primary cell cultures. In the present study, we focus on evaluating gene transfer vectors derived from infectious molecular clones of novel primate AAVs. Our study revealed that, in comparison with recombinant AAV2 genomes, packaging efficiency of recombinant AAV8 and AAVrh.39 genomes was significantly reduced, when trans-plasmids carrying both rep and cap genes from AAV8 and AAV rh.39, respectively, and Adhu5 helper plasmid were used for triple transfection of 293 cells. We speculated that incompatibility between replication and packaging of those novel primate vectors and helper gene functions from Adhu5 could be one of the causes for the deficiency. Identification and optimization of appropriate helper adenovirus with most likely a simian origin could be one of the strategies to overcome the packaging difficulty.
Exercise during pregnancy may increase birth weight
Authors: Scott Gottlieb
Journal: BMJ (2001)

Women who start a moderate exercise programme during early pregnancy may improve their likelihood of giving birth to a healthy baby, according to the results of a new study.

Dr James Clapp, professor of reproductive biology at Case Western Reserve University in Cleveland, Ohio, and colleagues studied 46 women who were not exercising regularly and were 8 weeks pregnant. The women were randomly asked to undertake either moderate weight bearing exercise three to five times a week (n=22) or no exercise for the …
EXPERIENCES WITH BALLISTOCARDIOGRAPHY
Authors: I D FAGIN, K E McINTYRE
Journal: Annals of Internal Medicine (1955)

Article1 May 1955EXPERIENCES WITH BALLISTOCARDIOGRAPHYI. DONALD FAGIN, M.D., F.A.C.P., KENNETH E. MCINTYRE, M.D.I. DONALD FAGIN, M.D., F.A.C.P.Search for more papers by this author, KENNETH E. MCINTYRE, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-42-5-995 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptINTRODUCTIONFor the last three years we have been interested in evaluating direct body ballistocardiography as an aid in office and clinic cardiology. The literature on ballistocardiography now includes three monographs and close to 400 articles. Current interest in this field is due in great measure to the studies of Dr. Isaac Starr, of Philadelphia, and the interested reader is referred to his latest paper1 and to the monographs2-4 for further study and bibliography.The ballistocardiogram is a means of recording the motions imparted to the body by contractions of the heart and by impacts and decelerations of the blood...Bibliography1. Starr I: Essay on the ballistocardiogram, J. A. M. A. 155: 1413-1425, 1954. CrossrefMedlineGoogle Scholar2. DockMandelbaumMandelbaum WHRA: Ballistocardiography, 1953, The C. V. Mosby Company, St. Louis. Google Scholar3. BrowndeLallaEpsteinHoffman HRVMAMJ: Clinical ballistocardiography, 1952, The Macmillan Company, New York. Google Scholar4. Braunstein JR: The ballistocardiogram: a dynamic record of the heart beat, American Lecture Series, No. 143, 1953, Charles C Thomas, Publisher, Springfield, Illinois. Google Scholar5. Gubner R: Selective synchronous recording of the ballistocardiogram and electrocardiogram on a single channel, Circulation 4: 239, 1951. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Detroit, Michigan*Received for publication October 22, 1954.From the Medical Service of the Mount Carmel Mercy Hospital (I. D. F.), and The Health Institute (K. E. M.), Detroit, Michigan. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byCorrelation of the ballistocardiogram with the coronary angiogram and electrocardiogram in ischemic heart diseaseThe Usefulness and Reliability of the Dock Ballistocardiograph in Clinical MedicineRICHARD L. FULTON, M.D., F.A.C.P., NORMAN O. ROTHERMICH, M.D., F.A.C.P., WALDEMAR BERGEN, M.D.Die Coronarerkrankungen. Coronarinsuffizienz, Angina pectoris und HerzinfarktThe effect of sedation on the abnormal ballistocardiogram of fatigue 1 May 1955Volume 42, Issue 5Page: 995-1000KeywordsBloodHeartMedical services ePublished: 1 December 2008 Issue Published: 1 May 1955 PDF downloadLoading ...
Transcatheter closure of muscular ventricular septal defects with the amplatzer ventricular septal defect occluder: initial clinical applications in children11The Amplatzer VSD occluders were provided by AGA, Medical Corporation, Golden Valley, Minnesota. There were no sources of financial support.
Authors: Basil (Vasilios) D Thanopoulos, George S Tsaousis, Georgia N Konstadopoulou, Armine G Zarayelyan
Journal: Journal of the American College of Cardiology (1999)
Prediction of Complications Following Partial Nephrectomy: Implications for Ablative Techniques Candidates
Authors: Alessandro Larcher, Nicola Fossati, Zhe Tian, Katharina Boehm, Malek Meskawi, Roger Valdivieso, Vincent Trudeau, Paolo Dell’Oglio, Nicolò Buffi, Francesco Montorsi, Giorgio Guazzoni, Maxine Sun, Pierre I. Karakiewicz
Journal: European Urology (2015)
"Boutique medicine" in the US
Authors: L. Newman
Journal: BMJ (2002)

EDITOR—In Charatan's news piece on “boutique medicine” in the United States he sketched out a problem that is a symptom of a healthcare system in trouble.1 As a medical writer and observer of American health care, I would say that the problem is even more worrying than Charatan described. Now we have a system that is faltering not only for the uninsured and underinsured but for the fully insured too. I worry that this problem might go unrecognised unless research and advocacy embarrass Congress to intervene.

Recently, a fully insured friend of mine was referred for a cardiology consultation. When he arrived at the doctor's surgery for a stress test he was told that the practice no longer took his insurance. He had his examination, as one last favour from the doctor, who warned him …
GALL-BLADDER DISEASE IN ELDERLY PATIENTS
Authors: Julius Rosenthal
Journal: Annals of Internal Medicine (1944)

Article1 June 1944GALL-BLADDER DISEASE IN ELDERLY PATIENTSJULIUS ROSENTHAL, M.D.JULIUS ROSENTHAL, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-20-6-933 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe finding of gall-bladder disease in the course of autopsies on patients of advanced age is more than an occasional occurrence. The figures given by different authors vary. According to Kaufmann,1gall-stones were found in 10.9 per cent of 10,025 autopsies in Basle, two-thirds of them being women. Mentzner,2of the Mayo Clinic, found pathological evidence of gall-bladder disease in 62 per cent of the patients over 21 years of age operated upon there, 21.7 per cent of all autopsied adults having gall-stones. Crump,3on the basis of 1,000 autopsies performed in Vienna on patients, 80 per cent of whom...Bibliography1. KAUFMANN E: Gall stone disease, Cholelithiasis, Pathology II, 984-997. Google Scholar2. MENTZNER SH: Clinical and pathological study of cholecystitis and cholelithiasis, Surg., Gynec., and Obst., 1926, xlii, 782-793. Google Scholar3. CRUMP C: Incidence of gall stones and gall bladder disease, Surg., Gynec., and Obst., 1931, liii, 447-455. Google Scholar4. BURTON JA: Cholelithiasis: a summary, Glasgow Med. Jr., 1934, cxxi, 14-23. Google Scholar5. MOYNIHAN BG: An address on symptoms of gall bladder disease, British Med. Jr., 1908, ii, 1599. Google Scholar6. MAYO WJ: "Innocent" gall stones, a myth, Jr. Am. Med. Assoc., 1911, lvi, 1021-1024. CrossrefGoogle Scholar7. ROWLANDS RP: Bradshaw lecture on the surgery of the gall bladder and bile ducts. A review, Lancet, 1929, ii, 1075. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: New York, N. Y.*Received for publication November 27, 1942.From the Departments of Pathology of Central and Neurological Hospitals and Welfare Hospital, Welfare Island, New York City. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byEffects of aging on laboratory animals: I. Light and scanning electron microscopy of dog gallbladderOccult CholecystitisTHE LIVER, BILIARY TRACT AND PANCREAS IN THE AGED: AN ANATOMIC AND LABORATORY EVALUATION†Nutrition in geriatrics-psychological and somatic aspects 1 June 1944Volume 20, Issue 6Page: 933-939KeywordsAutopsyElderly ePublished: 1 December 2008 Issue Published: 1 June 1944 PDF downloadLoading ...
ICBP90, a novel human CCAAT binding protein, involved in the regulation of topoisomerase IIalpha expression.
Authors: Raphaël Hopfner, Marc Mousli, Jean-Marc Jeltsch, Angélique Voulgaris, Yves Lutz, Cristi Marin, Jean-Pierre Bellocq, Pierre Oudet, Christian Bronner
Journal: Cancer Research (2000)

The one-hybrid system with an inverted CCAAT box as the DNA target sequence was used to identify proteins acting on key DNA sequences of the promoter of the topoisomerase IIalpha gene. Screening of cDNA libraries from the leukemia Jurkat cell line and from the adult human thymus resulted in the isolation of a novel protein of 793 amino acids (89,758 Da). This protein has in vitro CCAAT binding properties and has been called ICBP90. Adult thymus, fetal thymus, fetal liver, and bone marrow, known as active tissues in terms of cell proliferation, are the tissues richest in ICBP90 mRNA. In contrast, highly differentiated tissues and cells such as the central nervous system and peripheral leukocytes are free of ICBP90 mRNA. Western blotting experiments showed a simultaneous expression of topoisomerase IIalpha and ICBP90 in proliferating human lung fibroblasts. Simultaneous expression of both proteins has also been observed in HeLa cells, but in both proliferating and confluent cells. Overexpression of ICBP90 in COS-1-transfected cells induced an enhanced expression of endogenous topoisomerase IIalpha. Immunohistochemistry experiments showed that topoisomerase IIalpha and ICBP90 were coexpressed in proliferating areas of paraffin-embedded human appendix tissues and in high-grade breast carcinoma tissues. We have identified ICBP90, which is a novel CCAAT binding protein, and our results suggest that it may be involved in topoisomerase IIalpha expression. ICBP90 may also be useful as a new proliferation marker for cancer tissues.