tbuckley/cabot-search huggingface dataset:
Treatment of pityriasis rubra pilaris with ustekinumab
Authors: J. Wohlrab, B. Kreft
Journal: British Journal of Dermatology (2010)

Journal Article Treatment of pityriasis rubra pilaris with ustekinumab Get access J. Wohlrab, J. Wohlrab Department of Dermatology and Venereology, Martin‐Luther‐University Halle‐Wittenberg, Ernst‐Kromayer‐Strasse 5, D‐06097 Halle (Saale), Germany E‐mail: johannes.wohlrab@medizin.uni‐halle.de Search for other works by this author on: Oxford Academic Google Scholar B. Kreft B. Kreft Department of Dermatology and Venereology, Martin‐Luther‐University Halle‐Wittenberg, Ernst‐Kromayer‐Strasse 5, D‐06097 Halle (Saale), Germany E‐mail: johannes.wohlrab@medizin.uni‐halle.de Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 163, Issue 3, 1 September 2010, Pages 655–656, https://doi.org/10.1111/j.1365-2133.2010.09855.x Published: 01 September 2010
Gas chromatography/mass spectroscopy based metabolic profiling reveals different metabolite patterns in normal non tumorigenic and tumorigenic human uroepithelial cells cultures
Authors: Kishore Pasikanti, Ho Chi, Chan Eric Chun Yong
Journal: Clinical Cancer Research (2007)

AACR Centennial Conference: Translational Cancer Medicine-- Nov 4-8, 2007; Singapore

B50 

Metabonomics, as one of the ‘-omics’ technologies involving modern analytical tools and chemometrics analysis, is used to characterize the biochemical pattern of endogenous metabolic composition in biological samples. In this study we show the application of GC/MS-based metabonomics to investigate the metabolic profiles of non tumorigenic human uroepithelial cells (HUC) and tumorigenic human uroepithelial cells (THUC) cultures. We have used a metabolite profiling approach to test the hypothesis that metabonomic signatures of primary metabolites can be used to characterize molecular changes.    A 200 µL of cell culture media was used for analysis. Sample preparation involved protein precipitation using ice cold ethanol. An aliquot of the mixture was separated, dried, trimethylsilyl (TMS) derivatized and 0.5µL of the derivatized extract was injected into the GC/MS system by split injection (1:5).    Metabonomic profiling of HUC and THUC samples in combination with pattern recognition techniques was performed to evaluate the changes in metabolome. Principal component analysis (PCA) followed by partial least-squares-discriminant analysis (PLS-DA) revealed differences between metabolite profiles of HUC and THUC cell cultures. All variables were mean-centred and pareto-scaled. This model contained two components, showing the performance statistics of R2X =0.585, R2Y = 0.938 and Q2Y (cumulative) = 0.642.    We conclude that metabonomics is a promising approach in addition to functional genomics and proteomics for analyses of molecular changes in malignant tumors.
A double-blind, randomized, placebo-controlled trial of topical tacrolimus 0·1% vs. clobetasol propionate 0·05% in childhood vitiligo
Authors: N. Ho, E. Pope, M. Weinstein, S. Greenberg, C. Webster, B.R. Krafchik
Journal: British Journal of Dermatology (2011)

Background Both clobetasol propionate 0·05% (CP 0·05%) and tacrolimus 0·1% (T 0·1%) ointments have been shown to be efficacious and safe in treating vitiligo in the paediatric population. Objectives To assess efficacy and safety of these two therapies compared with each other and with placebo. Methods In this prospective study, children aged 2–16 years with vitiligo, stratified into 'facial' (n =55) and 'nonfacial' (n =45) groups, were randomized into three arms: CP 0·05% ointment (n =30), T 0·1% ointment (n =31) and placebo (n =29) for 6 months. Successful repigmentation, defined as > 50% improvement, was evaluated by comparing photographs taken at baseline and at 2, 4 and 6 months. Results In the facial group, 58% of the CP 0·05% group responded successfully compared with 58% of the T 0·1% group, and in the nonfacial group, 39% of the CP 0·05% group responded compared with 23% of the T 0·1% group (P >0·05). There was a significant difference in response between the CP 0·05% group vs. placebo (P <0·0001) and the T 0·1% group vs. placebo (P =0·0004). Spontaneous repigmentation was evaluated as 2·4%. No significant clinical adverse events were noted in any group. Conclusions Both CP 0·05% and T 0·1% ointments offer similar benefit in paediatric vitiligo, both facial and nonfacial. The facial lesions responded faster than the nonfacial ones.
Foreign-Body Tumors of Mice: Strain and Sex Differences in Latency and Incidence2
Authors: lnge Brand, Lance C. Buoen, K. Gerhard Brand
Journal: JNCI Journal of the National Cancer Institute (1977)

Sarcomas were induced by sc implantation of unplasticized polyvinylchloride acetate films in female and male mice of strains AKR/J, BALB/cJ, BALB/cWat, CBA/H and CBA/H-T6, C3H/HeJ, C57BL/10ScSn, C57BL/6J-bgj, C57BL/cdJ, DBA/-1J l/LnJ, LP/J, SJL/J, X/Gf, 129/J, and hybrids (CBA/H-T6 X AKR/J)F1, (C57BL/10ScSn x CBA/H or CBA/H-T6)F1, (C57BL/6J-bgj x C57BL/6J)F1. The strains and sexes showed marked differences in incidence and mean latency of resulting tumors. Crucial information was provided for the selection of appropriate mouse strains for the study of interrelationships between genotypes, defined somatic properties, and the multifactorial process of foreign-body tumorigenesis.
Chaperones for genital examination
Authors: M. Croft, J. Morrow, S. Randall, A. Webb, M. Kishen
Journal: BMJ (1999)

Editor—Bignell states in his editorial that “it is difficult not to proceed with a clinically indicated examination if the patient declines a chaperone, providing the physician feels comfortable in this situation.”1 I would say that this reads in much the same way as “it is difficult not to proceed with sexual intercourse if the man declines to use a condom, providing the woman feels comfortable in this situation.” The analogy is valid, I believe, as sexually transmitted disease (including HIV infection and unwanted pregnancy) carries much the same mortality as allegations of sexual assault, to patient and doctor respectively, however comfortable they may feel at the time.
Frequency and impact of interstitial lung disease on clinical state and mortality in systemic scleroderma
Authors: Wafa Chebbi, Sophia Ayed, Nadia Boudawara, Leila Boussoffara, Sylvia Mahjoub, Mohamed Habib Sfar, Jalel Knani
Journal: European Respiratory Journal (2012)

Background:  Interstitial lung disease (ILD) is a frequent complication and a leading cause of morbidity and mortality in Systemic Scleroderma (SSc).  The aim of our study was to determine the frequency of ILD in a cohort of Tunisian SSc and to assess the influence of this association on clinical, biological features and outcome of SSc.   Methods:  A retrospective study included 30 consecutive patients with SSc who fulfilled the American Rheumatism Association9s criteria. Patients were divided in two groups according to the occurrence (group 1) or not (group 2) of ILD. We compared the epidemiological, clinical, laboratory features and outcomes between the two groups. The data were compared by the Chi squared correct by fisher exact test and student test.   Results:  Thirteen patients (43, 3%) developed ILD. The patients were 12 women and one men, aged between 15 and 71 years (mean: 47.1 years) with the duration of the disease ranging from 4 to 348 months (mean: 81.7 months).  The most common presenting complaints are dyspnoea on exertion in 76.9% and dry cough in 46.1%. The ILD was asymptomatic in 3 cases (23%).  The comparison of the two groups showed that digital pitting, inflammatory syndrome and anti-Scl70 antibodies were significantly more common in the group 1. No differences were noted concerning sex ratio, mean age at SSc onset and delay of diagnosis. However, mortality rate was significantly higher in patients with ILD (46.1% vs 6.2%, p=0,025).   Conclusion:  Our study confirms that ILD is a common manifestation of SSc, mainly encountered in patients with anti-SCL 70 antibodies and associated with poor prognosis.
What is the Clinical Effectiveness of Erythropoiesis Stimulating Agents for the Treatment of Cancer Treatment-Induced Anaemia?
Authors: L. Crathorne, N. Huxley, M. Haasova, T. Snowsill, T. Jones-Hughes, M. Hoyle, S. Briscoe, H. Coelho, L. Long, A. Medina-Lara, R. Mujica-Mota, M. Napier, C. Hyde
Journal: Annals of Oncology (2014)
An Invasive or Conservative Strategy in Patients With Diabetes Mellitus and Non–ST-Segment Elevation Acute Coronary Syndromes
Authors: Michelle L. O'Donoghue, Ajay Vaidya, Rizwan Afsal, Joakim Alfredsson, William E. Boden, Eugene Braunwald, Christopher P. Cannon, Tim C. Clayton, Robbert J. de Winter, Keith A.A. Fox, Bo Lagerqvist, Peter A. McCullough, Sabina A. Murphy, Rudolf Spacek, Eva Swahn, Fons Windhausen, Marc S. Sabatine
Journal: Journal of the American College of Cardiology (2012)
Prevention of Paralysis and Suppression of Lymphoma in Wild Mice by Passive Immunization to Congenially Transmitted Murine Leukemia Virus23
Authors: Murray B. Gardner, John D. Estes, John Casagrande, Suraiya Rasheed
Journal: JNCI Journal of the National Cancer Institute (1980)

Journal Article Prevention of Paralysis and Suppression of Lymphoma in Wild Mice by Passive Immunization to Congenially Transmitted Murine Leukemia Virus Get access Murray B. Gardner, Murray B. Gardner 4Department of Pathology, School of Medicine, University of Southern California, Los Angeles, Calif. 90033. Search for other works by this author on: Oxford Academic PubMed Google Scholar John D. Estes, John D. Estes 4Department of Pathology, School of Medicine, University of Southern California, Los Angeles, Calif. 90033. Search for other works by this author on: Oxford Academic PubMed Google Scholar John Casagrande, John Casagrande 5Department of Community and Family Medicine, School of Medicine, University of Southern California. Search for other works by this author on: Oxford Academic PubMed Google Scholar Suraiya Rasheed Suraiya Rasheed 4Department of Pathology, School of Medicine, University of Southern California, Los Angeles, Calif. 90033. 6We thank Ms. Teresa Zavala, Ms. Mary Dougherty, and Mr. Craig McAllister for excellent technical assistance; Dr. Malcolm Pike for statistical analyses; and Ms. Ann Dawson for preparation of the manuscript. Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 64, Issue 2, February 1980, Pages 359–364, https://doi.org/10.1093/jnci/64.2.359 Published: 01 February 1980 Article history Received: 17 April 1979 Accepted: 23 July 1979 Published: 01 February 1980
Uterine Neoplasms, Version 1.2014
Authors: Wui-Jin Koh, Benjamin E. Greer, Nadeem R. Abu-Rustum, Sachin M. Apte, Susana M. Campos, John Chan, Kathleen R. Cho, David Cohn, Marta Ann Crispens, Nefertiti DuPont, Patricia J. Eifel, Amanda Nickles Fader, Christine M. Fisher, David K. Gaffney, Suzanne George, Ernest Han, Warner K. Huh, John R. Lurain, Lainie Martin, David Mutch, Steven W. Remmenga, R. Kevin Reynolds, William Small, Nelson Teng, Todd Tillmanns, Fidel A. Valea, Nicole McMillian, Miranda Hughes
Journal: Journal of the National Comprehensive Cancer Network (2014)

Adenocarcinoma of the endometrium (also known as endometrial cancer or more broadly as uterine cancer or carcinoma of the uterine corpus) is the most common malignancy of the female genital tract in the United States. An estimated 49,560 new uterine cancer cases will occur in 2013, with 8190 deaths resulting from the disease. Uterine sarcomas (stromal/mesenchymal tumors) are uncommon malignancies, accounting for approximately 3% of all uterine cancers. The NCCN Guidelines for Uterine Neoplasms describe malignant epithelial carcinomas and uterine sarcomas; each of these major categories contains specific histologic groups that require different management. This excerpt of these guidelines focuses on early-stage disease.
An Online Educational Facility for Medical Oncology Trainees: www.vmotg.org
Authors: Michael Jefford, Kelly-Anne Phillips, Martin H.N. Tattersall
Journal: Journal of Clinical Oncology (2001)

To design, implement, and evaluate a comprehensive educational Web site for medical oncology trainees.The Web site was designed with three main areas (termed Journal Club, Key Papers, and Oncology Links) and compiled from articles presented at the Victorian Medical Oncology Trainees' Group journal club from the preceding 3 years. The Key Papers section was then reviewed by 30 academic medical oncologists. The site was advertised by mail and at the Annual Meeting of the Medical Oncology Group of Australia. Evaluation was by mail survey.The Web site, which may be accessed at www.vmotg.org, comprises more than 170 pages and 30,000 words of text. Journal club sessions are summarized with presented articles linked to abstracts from PubMed. Key Papers lists from five to 25 pivotal articles in each of 35 categories. Oncology Links is an extensive list of links in 10 categories including organizations, journals, and practice guidelines. Twenty-six of 45 trainees and 82 of 190 oncologists responded to the survey. Eighty-one percent of these trainees and 28% of oncologists have used the Web site. Ninety-six percent consider the Web site easy to use and "a useful medical oncology resource." All trainees rated the site good to excellent in terms of relevance and 94% considered the site beneficial to their education.The Web site www.vmotg.org is a relevant and useful educational resource for Australian medical oncology trainees and oncologists. As far as the authors are aware, this is the only educational site specifically for medical oncology trainees throughout the world. It may be a valuable oncology education resource for trainees in other countries, particularly those in isolated areas.
Traffic-Related Air Pollution and Dementia Incidence in Northern Sweden: A Longitudinal Study
Authors: Anna Oudin, Bertil Forsberg, Annelie Nordin Adolfsson, Nina Lind, Lars Modig, Maria Nordin, Steven Nordin, Rolf Adolfsson, Lars-Göran Nilsson
Journal: Environmental Health Perspectives (2015)

BackgroundExposure to ambient air pollution is suspected to cause cognitive effects, but a prospective cohort is needed to study exposure to air pollution at the home address and the incidence of dementia.ObjectivesWe aimed to assess the association between long-term exposure to traffic-related air pollution and dementia incidence in a major city in northern Sweden.MethodsData on dementia incidence over a 15-year period were obtained from the longitudinal Betula study. Traffic air pollution exposure was assessed using a land-use regression model with a spatial resolution of 50 m × 50 m. Annual mean nitrogen oxide levels at the residential address of the participants at baseline (the start of follow-up) were used as markers for long-term exposure to air pollution.ResultsOut of 1,806 participants at baseline, 191 were diagnosed with Alzheimer’s disease during follow-up, and 111 were diagnosed with vascular dementia. Participants in the group with the highest exposure were more likely than those in the group with the lowest exposure to be diagnosed with dementia (Alzheimer’s disease or vascular dementia), with a hazard ratio (HR) of 1.43 (95% CI: 0.998, 2.05 for the highest vs. the lowest quartile). The estimates were similar for Alzheimer’s disease (HR 1.38) and vascular dementia (HR 1.47). The HR for dementia associated with the third quartile versus the lowest quartile was 1.48 (95% CI: 1.03, 2.11). A subanalysis that excluded a younger sample that had been retested after only 5 years of follow-up suggested stronger associations with exposure than were present in the full cohort (HR = 1.71; 95% CI: 1.08, 2.73 for the highest vs. the lowest quartile).ConclusionsIf the associations we observed are causal, then air pollution from traffic might be an important risk factor for vascular dementia and Alzheimer’s disease.CitationOudin A, Forsberg B, Nordin Adolfsson A, Lind N, Modig L, Nordin M, Nordin S, Adolfsson R, Nilsson LG. 2016. Traffic-related air pollution and dementia incidence in northern Sweden: a longitudinal study. Environ Health Perspect 124:306–312; http://dx.doi.org/10.1289/ehp.1408322
A comparison of the efficacy of Cetirizine and terfenadine
Authors: L. Andri, G. E. Senna, C. Betteli, S. Givanni, G. Andri, C. Lombardi, P. Mezzelani
Journal: Allergy (1993)

In a 20‐d, double‐blind, randomized, parallel study, the efficacy of cetirizine and terfenadine was compared in 30 patients with chronic idiopathic urticaria. Subjects were randomly divided into two 15‐patient groups. The first group was given cetirizine (10 mg once daily); the second terfenadine (60 mg twice daily). Cetirizine proved to be more effective than terfenadine in controlling urticaria symptoms. In fact, the score of the investigators' overall assessment was signifieantly lower in the cetirizine‐treated group than in the terfenadine‐treated group. Moreover, patient evaluation by a visual analog scale and symptoms assessed on a 4‐point scale showed a better improvement in the cetirizine group. The number and severity of side‐effects were similar in both treatment groups.
The prognostic value of CEA, βHCG, AFP, CA125, CA19-9 and C-erb B-2, (βHCG immunohistochemistry in advanced colorectal cancer
Authors: A. Webb, P. Scott-Mackie, D. Cunningham, A. Norman, J. Andreyev, M. O’Brien, J. Bensted
Journal: Annals of Oncology (1995)
Association between CT and spirometric changes in azithromycin treatment of chronic lung allograft dysfunction
Authors: Robin Vos, Pim de Jong, Stijn Verleden, Dirk Van Raemdonck, Lieven Dupont, Walter De Wever, Johny Verschakelen, Geert Verleden
Journal: European Respiratory Journal (2011)

Introduction: We investigated the association between CT and spirometric changes in chronic lung allograft dysfunction (CLAD) treated with azithromycin (AZI).

Methods: A cohort of 107 patients with CLAD treated with AZI, was retrospectively analyzed for inspiration and end-exhalation thin-section CT findings, as well as spirometry, before and after 3 to 12 m of therapy. CTs were scored by a single observer blinded for the spirometric data. CT and spirometric changes during treatment were correlated using Spearman rank test.

Results: A total of 100 patients had combined CT and spirometric data available at the start and after a median of 6.9 (4.7-11.4) m of treatment. Overall, all evaluated CT changes significantly correlated with the observed spirometric changes, except for MIF 50% (table/figure 1). Correlations between changes in specific CT features (i.e. consolidation and air trapping) and FVC or FEV1/FVC suggest that routine testing for restrictive pulmonary disease may be indicated in CLAD.

![Figure][1] 



![Figure][1] 



Conclusions: AZI treatment of CLAD results in various spirometric changes which are associated with changes in underlying CT abnormalities.

 [1]: pending:yes
Guinea Pig Leukemia L&lt;sub&gt;2&lt;/sub&gt;C: Characterization of Chromosomes and Attempts to Demonstrate Antigenicity
Authors: Harold T. Wepsic, Berton Zbar, Jacqueline Whang-Peng, Tibor Borsos, Herbert J. Rapp
Journal: JNCI Journal of the National Cancer Institute (1970)

The antigenicity of a transplantable strain-2 guinea pig leukemia was evaluated by transplantation protection tests. Pretreatment of animals with intradermal injections of sublethal doses of living leukemic cells did not consistently provide immunity to a subsequent challenge with living leukemic cells. The chromosomal constitution of the leukemia was studied in strain-2 and Hartley male and female guinea pigs. The chromosomal constitution of the leukemic cells was the same in animals of both sexes and strains. These biologic characteristics of guinea pig leukemia L2C are consistent with those of a long-transplanted, nonviral tumor.
The Nlrp3 Inflammasome Suppresses Colorectal Cancer Metastatic Growth in the Liver by Promoting Natural Killer Cell Tumoricidal Activity
Authors: Jeremy Dupaul-Chicoine, Azadeh Arabzadeh, Maryse Dagenais, Todd Douglas, Claudia Champagne, Alexandre Morizot, Ian Gaël Rodrigue-Gervais, Valérie Breton, Sara L Colpitts, Nicole Beauchemin, Maya Saleh
Journal: Immunity (2015)
Evolving Treatment Options for Locally Advanced Unresectable Pancreatic Ductal Adenocarcinoma
Authors: Pelin Cinar, Andrew H. Ko
Journal: Journal of the National Comprehensive Cancer Network (2014)

The best treatment strategy for patients with locally advanced unresectable pancreatic ductal adenocarcinoma (PDAC) remains the subject of considerable debate. This report presents a case of a 58-year-old woman with locally advanced unresectable PDAC who was treated with sequential FOLFIRINOX for 8 cycles followed by chemoradiation, and continues to show durable disease control 18 months later. The respective roles of systemic therapy and chemoradiation for locally advanced PDAC are discussed, including optimal sequencing of these modalities, recent improvements in chemotherapy, and the question of whether radiotherapy improves survival outcomes in this disease context.
Child Abuse: Pathological Syndrome of Family Interaction
Authors: ARTHUR H. GREEN, RICHARD W. GAINES, ALICE SANDGRUND
Journal: American Journal of Psychiatry (1974)

The authors observed patterns of family interaction frequently encountered in 60 cases of child abuse. The maltreatment syndrome is described as the end result of three potentiating factors: the abuse-prone personality of the parent; characteristics of the child that make him vulnerable for scapegoating; and current environmental stress. Role reversal was a prominent feature in the psychodynamic makeup of these families. The parents tended to endow the child with negative characteristics derived from their own experience with rejecting parents.
Abstract 133: Novel Transgenic Mouse Lines for Identification of Cardiomyocyte Nuclei and Visualization of Their Cell Cycle Status In-vitro and In-vivo
Authors: Alexandra Raulf, Hannes Horder, Caroline Geisen, Sabine Grünberg, Patricia Freitag, Bernd K Fleischmann, Michael Hesse
Journal: Circulation Research (2014)

The typical remodelling process after cardiac injury is scarring and compensatory hypertrophy. The limited regeneration potential of the adult heart is due to the post-mitotic status of cardiomyocytes (CMs), which are mostly binucleated. Nevertheless, there is evidence for CM turnover in the adult heart, but its extent is still under debate. One technical limitation of quantitations is the unequivocal identification of CMs and of CM cell division. In order to enable a clear identification of CM nuclei in-vivo, we have developed a transgenic mouse line in which a fusion protein of the human histone 2B and the red fluorescence protein mCherry is specifically and persistently expressed in CM nuclei (αMHC-H2B-mCh). The fluorescence label allowed the investigation of CM percentages in native tissue slices, which properly reflect the cellular composition of the heart. We focused on regional (atrium versus left and right ventricle, apical versus basal slices) and developmental-stage dependent changes in the percentage of CM nuclei and binuclearity. We therefore analyzed time-points before/during and after terminal differentiation of CMs (postnatal day 3 (P3), P7 and 9 weeks). In addition, we also investigated endoreduplication and acytokinetic mitosis using time lapse microscopy in postnatal CMs to better understand cell biological mechanisms leading to terminal differentiation. As currently huge efforts are invested for the search of substances that increase the regeneration potential of the heart, we established a novel screening assay for cell-cycle modifying substances in isolated, postnatal CMs. We crossed the αMHC-H2B-mCh with the CAG-eGFPanillin mouse line, which marks cell-cycle activity with a high resolution of M-phase. Analysis of binuclearity and of different eGFPanillin subcellular localizations will be helpful to understand, whether CMs complete cytokinesis. As a proof of principle we investigated the effects of cell cycle activating micro RNAs199 and 590. Thus, our double transgenic mouse line will be useful to examine the plasticity of mono- and binuclear CMs and to unravel cell biological mechanisms leading to terminal differentiation of CMs.