tbuckley/cabot-search huggingface dataset:
Studies of Platelets
Authors: Jack J. Rheingold, Edward Adelson, Arnold A. Lear
Journal: BMJ (1967)

Abstract : A technique was devised for obtaining a cohort of tagged young platelets in dogs. These studies reveal that dog platelets are randomly destroyed by the process of continuous in vivo coagulation. This process results in a half-life of 1.5 days. Dog platelets begin to die by aging when they reach 8 days, and no platelets survive beyond 12 days of age. However, in the normal dog less than two percent of the platelets survive theANDOM PROCESS OF DESTRUCTION FOR 8 DAYS SO THAT AGING PLAYS A NEGLIGIBLE ROLE IN DETERMINING PLATELET SURVIVAL. Neither warfarin nor heparin is able completely to stop the process of in vivo coagulation. Of the two, however, heparin appears to be more effective in dogs. A comparable study in humans reveals a similar random process of platelets destruction by continuous in vivo coagulation. The half-life of this process is 2.8 days. Senescence for human platelets begins on day 10 and is complete by day 15. Less than 3% of human platelets survive to day 10 and senescence. Heparin slows the random process of platelet destruction from the normal half-life of 2.8 days to a half-life of 7 days. (Author)
515. Mutation Independent Knockdown of Mutant mRNA by RNA Interference and Replacement by mRNA with Knockdown-Resistant Codons
Authors: Rajendra Kumar-Singh, Erin Binkley, Siobhan Cashman
Journal: Molecular Therapy (2004)

Purpose: Many dominant disorders present with a very heterogeneous mutation spectrum. Hence, it would be ideal to develop therapies that are mutation independent. RNA interference (RNAi) is a potentially powerful tool for the treatment of dominant diseases. More than 100 different mutations in the gene encoding rhodopsin cause a wide variety of diseases including autosomal dominant and recessive retinitis pigmentosa (RP), congenital stationary night blindness and retinitis punctata albescens. The purpose of this study was to explore the potential of RNAi to ameliorate dominant disease associated with mutations in rhodopsin.
A Treatise on the Science and Practice of Midwifery.
Authors: W. S. Playfair, Robert P. Harris
Journal: JAMA (1889)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Histopathological characterization of primary cutaneous melanoma using infrared microimaging: a proof-of-concept study
Authors: E. Ly, N. Cardot-Leccia, J.-P. Ortonne, M. Benchetrit, J.-F. Michiels, M. Manfait, O. Piot
Journal: British Journal of Dermatology (2010)

Journal Article Histopathological characterization of primary cutaneous melanoma using infrared microimaging: a proof‐of‐concept study Get access E. Ly, E. Ly Unité MéDIAN, CNRS UMR 6237 MEDyC, Université de Reims‐Champagne Ardenne, IFR 53, 51 rue Cognacq‐Jay, 51096 Reims Cedex, France Search for other works by this author on: Oxford Academic Google Scholar N. Cardot‐Leccia, N. Cardot‐Leccia Laboratoire Central d'Anatomie Pathologique, Hôpital Pasteur, CHU de Nice, 30 avenue de la Voie‐Romaine, 06000 Nice, France Search for other works by this author on: Oxford Academic Google Scholar J.‐P. Ortonne, J.‐P. Ortonne Service de Dermatologie, Hôpital de L'Archet 2, CHU de Nice, BP 3079, 06202 Nice Cedex 3, France Search for other works by this author on: Oxford Academic Google Scholar M. Benchetrit, M. Benchetrit Laboratoire Central d'Anatomie Pathologique, Hôpital Pasteur, CHU de Nice, 30 avenue de la Voie‐Romaine, 06000 Nice, France Search for other works by this author on: Oxford Academic Google Scholar J.‐F. Michiels, J.‐F. Michiels Laboratoire Central d'Anatomie Pathologique, Hôpital Pasteur, CHU de Nice, 30 avenue de la Voie‐Romaine, 06000 Nice, France Search for other works by this author on: Oxford Academic Google Scholar M. Manfait, M. Manfait Unité MéDIAN, CNRS UMR 6237 MEDyC, Université de Reims‐Champagne Ardenne, IFR 53, 51 rue Cognacq‐Jay, 51096 Reims Cedex, France Search for other works by this author on: Oxford Academic Google Scholar O. Piot O. Piot Unité MéDIAN, CNRS UMR 6237 MEDyC, Université de Reims‐Champagne Ardenne, IFR 53, 51 rue Cognacq‐Jay, 51096 Reims Cedex, France Olivier Piot. E‐mail:olivier.piot@univ‐reims.fr Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 162, Issue 6, 1 June 2010, Pages 1316–1323, https://doi.org/10.1111/j.1365-2133.2010.09762.x Published: 01 June 2010
Abstract 248: The Paradoxical Association Between Pulmonary Edema and Survival with Favorable Neurological Function After Cardiac Arrest
Authors: Guillaume Debaty, Tom P Aufderheide, Robert A Swor, Ralph J Frascone, Marvin A Wayne, Robert M Domeier, Michael L Olinger, Brian D Mahoney, Demetris Yannopoulos
Journal: Circulation (2014)

Introduction:  Pulmonary edema (PE) is a sign of heart failure. In a recent out-of-hospital cardiac arrest (OHCA) trial, the presence of PE was associated with increased survival with favorable neurological outcome (SFNO) [PE present (28/200 (14%) vs. no PE 119/1912 (6.2%), p   Methods:  Data related to the frequency of gasping and SFNO was available from 2007-2009 in the ResQTrial, a NIH-funded trial comparing S-CPR with ACD (ResQPUMP)+ITD(ResQPOD-16)( ACD+ITD manufacturer, Advanced Circulatory Systems, Roseville MN). PE was identified by prehospital fluid or secretions in the airway and/or roentgenographic evidence after hospital admission. SFNO was defined as a Modified Rankin Scale score ≤ 3 at hospital discharge.   Results:  PE was more frequent in gasping subjects [30/212 (14.2%)] vs. non-gasping subjects [144/1660 (8.7%)], p   Conclusions:  PE frequency in OHCA was associated with a >2 fold higher rate of survival to hospital discharge with good brain function during S-CPR and ACD+ITD. Increased PE was associated with increased gasping during ACD+ITD but not S-CPR. Higher gasping rates leading to lower intrathoracic pressures may underlie the unanticipated association between increased PE and SFNO with ACD+ITD but not with S-CPR.
Abstract 20127: Race and Insurance Status as Determinants of Prolonged Total Ischemic Time in ST Elevation Myocardial Infarction
Authors: Khaled I Khalaf, Stefano Sdringola, Prakash Balan, H V Anderson, James McCarthy, James Langabeer, Sangbum Choi, Richard W Smalling
Journal: Circulation (2014)

Introduction:  In STEMI, early reperfusion is imperative to preserve viability. The interval between steady ischemic symptom onset to first medical contact time (ST1) is a component of total ischemic time (IT) that has a large margin for improvement.   Hypothesis:  We hypothesized that ST1 is the main contributor to IT and can be influenced by specific patient demographics, characteristics and socio-economical status.   Methods:  We queried the database from an experienced urban-based STEMI accredited receiving center in Houston, TX from 2011 to 2014. We included only patients with STEMI who presented directly from the community to our hospital via EMS. IT was defined as the sum of ST1, first medical contact (FMC) to hospital arrival and arrival to first device activation (FDA) times. Patients transferred from outside facilities or without documented symptom onset, FMC or FDA times were excluded.   Results:  263 patients met the inclusion criteria: 52% White, 28% Black and 17% Hispanic. 48% had private insurance, 38% Medicare and 8% Medicaid. Mean ST1 was 117, FMC to arrival 49 and arrival to FDA 58 min. Mean ST1 comprised 41.7% of IT. Compared to other groups, the Black race was independently associated with the longest ST1 time at 156 ± 234 min (p = 0.05), Similarly, Medicaid insurance status showed the highest ST1 time at 283 ± 396 min (p    Conclusions:  1. Symptoms onset to first medical contact time (ST1) has the largest impact on total ischemic time in STEMI.  2. Black race and Medicaid insurance status are associated with a longer ST1 time.  3. Continued public education regarding prolonged myocardial ischemia is needed.
SLURP1 mutation-impaired T-cell activation in a family with mal de Meleda
Authors: J-W. Tjiu, P-J. Lin, W-H. Wu, Y-P. Cheng, H-C. Chiu, H-Y. Thong, B-L. Chiang, W-S. Yang, S-H. Jee
Journal: British Journal of Dermatology (2010)

Journal Article SLURP1 mutation‐impaired T‐cell activation in a family with mal de Meleda Get access J‐W. Tjiu, J‐W. Tjiu Department of Dermatology, National Taiwan University Hospital, Chung‐Shan South Road, Taipei 100, Taiwan Search for other works by this author on: Oxford Academic Google Scholar P‐J. Lin, P‐J. Lin Department of Dermatology, National Taiwan University Hospital, Chung‐Shan South Road, Taipei 100, Taiwan Search for other works by this author on: Oxford Academic Google Scholar W‐H. Wu, W‐H. Wu Department of Dermatology, National Taiwan University Hospital, Chung‐Shan South Road, Taipei 100, Taiwan Search for other works by this author on: Oxford Academic Google Scholar Y‐P. Cheng, Y‐P. Cheng Department of Dermatology, National Taiwan University Hospital, Chung‐Shan South Road, Taipei 100, Taiwan Search for other works by this author on: Oxford Academic Google Scholar H‐C. Chiu, H‐C. Chiu Department of Dermatology, National Taiwan University Hospital, Chung‐Shan South Road, Taipei 100, Taiwan Search for other works by this author on: Oxford Academic Google Scholar H‐Y. Thong, H‐Y. Thong Department of Dermatology, National Taiwan University Hospital, Chung‐Shan South Road, Taipei 100, Taiwan Search for other works by this author on: Oxford Academic Google Scholar B‐L. Chiang, B‐L. Chiang Graduate Institute of Clinical Medicine, National Taiwan University College of Medicine, Taipei, Taiwan Search for other works by this author on: Oxford Academic Google Scholar W‐S. Yang, W‐S. Yang Graduate Institute of Clinical Medicine, National Taiwan University College of Medicine, Taipei, Taiwan Search for other works by this author on: Oxford Academic Google Scholar S‐H. Jee S‐H. Jee Department of Dermatology, National Taiwan University Hospital, Chung‐Shan South Road, Taipei 100, Taiwan Correspondence: Shiou‐Hwa Jee. E‐mail: shiouhwa@gmail.com; shiouhwa@ntu.edu.tw Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 164, Issue 1, 1 January 2011, Pages 47–53, https://doi.org/10.1111/j.1365-2133.2010.10059.x Published: 01 January 2011
Mental Growth and Control.
Authors: Nathan Oppenheim
Journal: JAMA (1902)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Social policy more important for health than medicines, conference told
Authors: Tessa Richards
Journal: BMJ (1999)

Policies which improve people's social and physical environment should be pursued to promote public health in the next century, a group of international experts concluded at a meeting last week in London organised by the Office of Health Economics.

Spending more money on health care and measures to change individuals' behaviour is unlikely to have as much effect as investing in policies that promote sustainable development, protect the environment, promote equity, and tackle the social gradient in health.

Mortality in the United Kingdom has fallen steadily in the past 25 years, largely due to a continuing decline in deaths from infectious disease and ischaemic heart disease. Morbidity …
Cockroaches as models for neurobiology (applications in biomedical research, vols 1 and 2)edited by I. Huber, E. P. Masler and B. R. Rao, CRC Press, 1990. £120.00 (3 + 326 pages) ISBN 0 849 34839 0
Authors: P USHERWOOD
Journal: Trends in Neurosciences (1991)
New formula for GP prescribing budgets
Authors: A. Majeed
Journal: BMJ (2000)

General practice pp 284,288

In today's BMJ Rice and colleagues describe the derivation of a formula for allocating prescribing budgets to health authorities and primary care groups in England (p 284).1 The formula is based on the most comprehensive analysis of general practice prescribing costs so far and—despite criticisms such as those outlined by Baines et al on p 2882—is likely to be the best available for the foreseeable future. The new formula will be used to help set target allocations and has several important implications.

Firstly, the new formula represents a major change in the methods used to allocate NHS budgets. The various formulas currently used have four main components: a population count; weightings for age and sex;measures of health need; and a component for unavoidable factors. The most important is the population count. Traditionally the population counts have been the estimated resident population for each health authority. The new formula for prescribing budgets will use general practice lists …
Abstract 9915: A Less-Invasive and Quantitative Prediction for Periprocedural Myocardial Injuries During Elective Percutaneous Coronary Intervention by Detection of High-intensity Plaques on Non-contrast T1-weighted Magnetic Resonance Imaging
Authors: Yasuhide Asaumi, Teruo Noguchi, Yoshiaki Morita, Reiko Fijiwara, Tomoaki Kanaya, Taka-aki Matsuyama, Tomohiro Kawasaki, Masashi Fujino, Toshiyuki Nagai, Takafumi Yamane, Tadayoshi Miyagi, Hatsue Ishibashi-Ueda, Masahiro Higashi, Masaharu Ishihara, Hisao Ogawa, Satoshi Yasuda
Journal: Circulation (2014)

Background: Periprocedural myocardial injuries (pMI) are associated with immediate and long-term adverse outcomes due to distal embolization. Coronary high-intensity plaques (HIPs) detected on non-contrast T1-weighted imaging (T1WI) are associated with characteristics of vulnerable plaques, including positive remodeling, lower Hounsfield units on computed tomography, and ultrasound attenuation. We hypothesized that coronary HIPs may predict pMI during elective percutaneous coronary intervention (PCI). Methods: Fifty-seven consecutive patients with coronary artery disease underwent cardiac magnetic resonance (CMR) within 3 months prior to PCI to calculate the plaque-to-myocardium signal intensity ratio (PMR: Figure A). pMI was defined as cardiac troponin T elevation of more than 5 times the 99th percentile of the upper reference limit. Results: CMR studies were performed a median of 2 days (interquartile range (IQR), 1-24) before the PCI. Following PCI, 6 patients (11%) and 15 patients (27%), respectively,...
Abstract 11924: Phenotypes of Heart Failure Identified via Cluster Analysis Do Not Recapitulate Hemodynamic Profiles: Insights From the ESCAPE Trial
Authors: Tariq Ahmad, Allison Dunning, Phillip Schulte, Joseph Rogers, Christopher O’Connor, Michael Felker, Chetan Patel
Journal: Circulation (2014)

Background: Heart failure (HF) classification criteria do not adequately describe disease state. We used cluster analysis to identify distinct phenotypes of patients in the pulmonary artery catheter (PAC) arm of the ESCAPE trial, and examine association of clusters with hemodynamic profiles. Methods: Cluster analysis was performed on baseline clinical variables and PAC measurements in a cohort of 172 subjects from the ESCAPE trial, a randomized study examining PAC versus usual care in advanced systolic HF patients. ANOVA examined association between patient clusters and clinically determined hemodynamic profiles (warm/cold/wet/dry); association with clinical outcomes was assessed using Cox proportional hazards models. Results: Four HF clusters were identified with the following general characteristics: Cluster 1(n=75): Male Caucasians with ischemic cardiomyopathy, multiple comorbidities, lowest BNP levels; Cluster 2 (n=33): Females with non-ischemic cardiomyopathy, few comorbidities, most favorable hemodynamics; Cluster 3 (n=29): Young African American males with non-ischemic cardiomyopathy, most adverse hemodynamics and advanced disease; Cluster 4 (n=25): Older Caucasians with ischemic cardiomyopathy, concomitant renal insufficiency, and highest BNP levels. We noted no association between hemodynamic profiles and clusters (P=0.70). Cluster 4 patients had the highest risk of all adverse clinical outcomes, whereas cluster 2 had the lowest. Compared to patients in cluster 4, patients in other clusters had 45-70% lower risk of all-cause mortality. Conclusions: Using a novel approach that clusters patients according to similar clinical variables and PAC measures, we identified 4 clinically relevant phenotypes of HF patients, with no discernable relationship to hemodynamic profiles. Our analysis suggests that HF classification can be enhanced by simultaneous considerations of etiology, comorbid conditions, and biomarker levels.
Abstract 12061: Insights Into CT Contrast Uptake by Atheroma-Associated Macrophages in Hyperlipidemic Rabbits
Authors: Delia Danila, Vaishali Bagalkot, Patrick Kee
Journal: Circulation (2014)

Introduction: Visualization of macrophage activities and distribution may provide useful insight into plaque vulnerability.

Hypothesis: Uptake of phosphatidylserine (PS)-coated liposomes by macrophages in the arterial wall will generate contrast enhancement for CT imaging.

Methods: Efficient loading of liposomes was accomplished by a modified ethanol vaporization method. Pharmacokinetic parameters and tissue distribution of liposomes were evaluated in mice and New Zealand White (NZW) rabbits. Both Watanabe Hereditary Hyperlipidemic (WHHL) and balloon-denuded cholesterol-fed NZW rabbits were injected with control and PS-liposomes, and imaged 48 hours later with a flat-panel CT scanner. Image processing and reconstruction were performed to demonstrate contrast enhancement in the aorta. Immunohistochemical and immunofluorescence microscopy were used to characterize contrast uptake in relation to macrophage distribution.

Results: Iodixanol in liposomes ranged from 65 to 80 mg/ml. In vitro liposomal uptake by macrophages increased with increasing percentage of PS in the liposomes and cell viability was unaffected up to 20% PS. Liposomally encapsulated iodixanol prolonged blood pool enhancement up to 4h after injection and diverted its clearance to the reticuloendothelial system. Only the 100nm PS-liposomes generated specific aortic wall enhancement in association with atheroma. Histological examination revealed diffused non-specific retention of 100nm control liposomes and the absence of 200 nm control and PS-liposomes in the aortic wall. Only 100nm PS-liposomes specifically co-localized with plaque-associated macrophages in both rabbit models.

Conclusions: In vivo uptake of CT contrast by plaque-associated macrophages is dependent on liposome size and surface modifications. Molecular imaging of macrophage retention of CT contrast is feasible with sufficient payload in the liposomal carrier.

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The Indications for and the Results of Artificial Pneumothorax Treatment in Pulmonary Tuberculosis
Authors: J. Burns Amberson
Journal: Annals of Internal Medicine (1930)

Article1 October 1930The Indications for and the Results of Artificial Pneumothorax Treatment in Pulmonary TuberculosisJ. BURNS AMBERSON JR.J. BURNS AMBERSON JR.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-4-4-343 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptPulmonary tuberculosis, recognized and treated properly in its very early stages, especially before softening and excavation have occurred, is a very healable disease. The problem of treatment would be relatively simple if it could be instituted always in this early most favorable stage. But the fact is that at least seventy-five per cent of tuberculous patients are in the moderately advanced or far advanced stage of the disease before they are correctly diagnosed and persuaded that treatment is necessary. Actually, therefore, one of our chief responsibilities is the care of advanced cases.Once the minimal or early stage of pulmonary... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: †From the Loomis Sanatorium, Loomis, N. Y., and the Tuberculosis Division of Bellevue Hospital, New York City.*Read before the American College of Physicians at the Minneapolis Meeting, February 14, 1930, as part of a symposium on "The Surgery of Pulmonary Tuberculosis." Nextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byA STUDY CONCERNING CLINICAL AND ANATOMIC FEATURES OF RE-EXPANDED LUNGS WHICH HAD BEEN COLLAPSED BY PNEUMOTHORAX FOR VARIABLE PERIODS OF TIMESTANDARDS AND CRITERIA IN ARTIFICIAL PNEUMOTHORAX THERAPYKann man die Phrenicusexairese als Methode der Wahl bei einseitigen Kavernösen Prozessen bedingungslos empfehlen? (Geringgrdiger Prozentsatz von Kaernenschließungen. Magenbeschwerden und Miliartuberkulose als Komplikationen)THE PRESENT STATUS OF ONE HUNDRED PNEUMOTHORAX PATIENTS AFTER FROM ONE TO EIGHTEEN YEARS’ EXPANSION OF THE LUNG 1 October 1930Volume 4, Issue 4Page: 343-347KeywordsPulmonary diseasesSurgery ePublished: 1 December 2008 Issue Published: 1 October 1930 PDF downloadLoading ...