HYPOFIBRINOGENEMIA WITHOUT FIBRINOLYSIS ASSOCIATED WITH A LYMPHOMA AND CONTROLLED AFTER TREATMENT WITH CORTISONE AND NITROGEN MUSTARD
Authors: J E MIDDLEBROOK
Journal: Annals of Internal Medicine (1957)

Case Reports1 December 1957HYPOFIBRINOGENEMIA WITHOUT FIBRINOLYSIS ASSOCIATED WITH A LYMPHOMA AND CONTROLLED AFTER TREATMENT WITH CORTISONE AND NITROGEN MUSTARDJOHN E. MIDDLEBROOK, M.D.JOHN E. MIDDLEBROOK, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-47-6-1242 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptHypofibrinogenemia has been recognized more frequently in recent years. Congenital afibrinogenemia, a condition caused by a congenital defect in the enzyme system responsible for fibrinogen production, has been recognized for many years. Acquired afibrinogenemia has been observed as a complication of shock,1severe liver damage associated with a septic abortion and bacteremia,2pulmonary surgery,3severe tissue damage,4inadequate protein intake,5thrombotic thrombocytopenic purpura,6polycythemia,7and the various complications of pregnancy, including abruptio placentae, intra-uterine death, and amniotic fluid embolism.8, 9, 10Acquired hypofibrinogenemia has also been observed in association with various malignant growths, including carcinoma of the prostate,11, 12pancreas13,...Bibliography1. TagnonLevensonDavidsonTaylor HJSMCSFH: The occurrence of fibrinolysis in shock with observations on the prothrombin time and the plasma fibrinogen during hemorrhagic shock, Am. J. M. Sc. 211: 88, 1946. CrossrefMedlineGoogle Scholar2. ConleyRatnoffHartman CLODRC: Studies on afibrinogenemia: afibrinogenemia in a patient with septic abortion, acute yellow atrophy of the liver, and bacteremia due to E. coli , Bull. 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HodgkinsonLuzadnePifen CPJHPW: Hypofibrinogenemia and defects of coagulation, Obst. and Gynec. 5: 465, 1955. Google Scholar10. JacksonHartmanBusby DFRCT: Fibrinogenopenia complicating pregnancy, Obst. and Gynec. 5: 223 (Mar.) 1955. Google Scholar11. TagnonWhitmoreShulman HJWFNR: Fibrinolysis in metastatic cancer of the prostate, Cancer 5: 9, 1952. CrossrefMedlineGoogle Scholar12. TagnonWhitmoreSchulmanKravitz HJWFPSC: The significance of fibrinolysis occurring in patients with metastatic cancer of the prostate, Cancer 6: 63, 1953. CrossrefMedlineGoogle Scholar13. Ratnoff OD: Studies on a proteolytic enzyme in human plasma. VII. A fatal hemorrhagic state associated with excessive plasma proteolytic activity in a patient undergoing surgery for carcinoma of the head of the pancreas, J. Clin. Investigation 31: 521, 1952. CrossrefMedlineGoogle Scholar14. MackayMansellHertig DGHAT: Carcinoma of the body of the pancreas with fibrinogenopenia, Cancer 6: 862, 1953. CrossrefMedlineGoogle Scholar15. BennikeMullertz TS: Haemorrhagic diathesis associated with fibrinogenopenia and fibrinolysis, Acta haemat. 8: 147, 1952. CrossrefMedlineGoogle Scholar16. PisciottaSchulz AVEJ: Fibrinolytic purpura in acute leukemia, Am. J. Med. 19: 824, 1955. CrossrefMedlineGoogle Scholar17. CooperburgNeiman AAGA: Fibrinogenopenia and fibrinolysin in acute myelogenous leukemia, Ann. Int. Med. 42: 706, 1955. LinkGoogle Scholar18. GittinBonges DWH: Studies on the metabolism of fibrinogen in two patients with congenital afibrinogenemia, Blood 8: 679, 1953. CrossrefMedlineGoogle Scholar19. SoichenRichardsRose RRPB: The estimation of profibrinolysin, J. Lab. and Clin. Med. 43: 495, 1954. MedlineGoogle Scholar20. RatnoffConley ODCL: Studies on afibrinogenemia. II. The defibrinating effect on dog blood of intravenous injection of thromboplastic material, Bull. Johns Hopkins Hosp. 88: 414, 1951. MedlineGoogle Scholar21. ClifftonCrossi EECE: Fibrinolytic activity of human tumors as measured by the fibrin plate method, Cancer 8:1146 (Dec.) 1955. CrossrefMedlineGoogle Scholar22. StefaniniGendel MB: Influence of fibrinolysin on the survival "in vivo" of various coagulation factors and favorable influence of cortisone in fibrinolytic purpura, Proc. Am. Federation Clin. Research 1: 5, 1953. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Iowa City, Iowa*Received for publication December 29, 1956. (Presented at the VI Congress, International Society of Hematology, Boston, Massachusetts, August, 1956.)From the Veterans Administration Hospital and the Department of Medicine, State University of Iowa, College of Medicine.Requests for reprints should be addressed to John E. Middlebrook, M.D., 701 Physicians and Surgeons Building, Minneapolis, Minnesota. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byBilateral ophthalmic artery occlusion in a patient with aquired immunodeficiency syndrome and central nervous system lymphoma1 1The authors have no proprietary interest relative to any aspect of this report.De novo disseminated intravascular coagulation in angioimmunoblastic lymphadenopathy (AILD)Prothrombin, thrombin and prothrombin fragments in plasma of normal individuals and of patients with laboratory evidence of disseminated intravascular coagulationBLEEDING AND INTRAVASCULAR CLOTTING IN MALIGNANCY: A REVIEWChronic Intravascular Coagulation SyndromeCoexistent hypercoagulability and acute hypofibrinogenemia in a patient with prostatic carcinoma 1 December 1957Volume 47, Issue 6Page: 1242-1251KeywordsHematology and oncologyHemoglobinHemorrhageHospital medicineLiverLymphomaPregnancyProteinsPulmonary embolismResearch laboratories ePublished: 1 December 2008 Issue Published: 1 December 1957 PDF downloadLoading ...