THE RÔLE OF THE UPPER SMALL INTESTINE IN THE CONTROL OF GASTRIC SECRETION; THE EFFECT OF NEUTRAL FAT, FATTY ACID, AND SOAPS; THE PHASE OF GASTRIC SECRETION INFLUENCED AND THE RELATIVE IMPORTANCE OF THE PSYCHIC AND CHEMICAL PHASES
Authors: Harry Shay, J. Gershon-Cohen, Samuel S. Fels
Journal: Annals of Internal Medicine (1939)

Article1 August 1939THE RÔLE OF THE UPPER SMALL INTESTINE IN THE CONTROL OF GASTRIC SECRETION; THE EFFECT OF NEUTRAL FAT, FATTY ACID, AND SOAPS; THE PHASE OF GASTRIC SECRETION INFLUENCED AND THE RELATIVE IMPORTANCE OF THE PSYCHIC AND CHEMICAL PHASESHARRY SHAY, M.D., J. GERSHON-COHEN, M.D., D.SCI. (MED.), SAMUEL S. FELS, LL.D.HARRY SHAY, M.D., J. GERSHON-COHEN, M.D., D.SCI. (MED.), SAMUEL S. FELS, LL.D.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-13-2-294 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe prohibition in Leviticus†: "Ye shall eat no manner of fat, of ox, or of sheep, or of goat," might mean that the ancients were aware of the retardation of gastric digestion by fats. Certainly Aristotle, in his Problemata,‡ discussed the effect of fat upon digestion in the stomach with an assurance that indicated much observation and thought.In 1886 Ewald and Boas1demonstrated that fat in the upper digestive tract decreased gastric activity. Beaumont,2too, had previously stressed the difficulty of digestion of oily foods. From Pavlov's laboratory, however, came the first experiments proving that fat diminished gastric secretion....Bibliography1. EWALDBOAS CAJ: Beiträge zur Physiologie und Pathologie der Verdauung, Arch. Path. u. Anat., 1886, civ, 271. CrossrefGoogle Scholar2. BEAUMONT W: Experiments and observations on gastric juice in man, 1883, Plattsburg. Google Scholar3. KHIGINE P: Activité sécrétoire de l'estomac du chien, Arch. d. sci. biol., 1894-1895, iii, 461. Google Scholar4. LOBASSOFF JO: Sur l'excitabilité sécrétoire spécifique de la muqueuse du canal digestif, Arch. d. sci. biol., 1897, v, 425. Google Scholar5. LECONTE P: Fonctions gastro-intestinales, La Cellule, 1900, xvii, 285. Google Scholar6. SOKOLOV A: Analysis of the secretory action of the stomach of the dog, 1904, Thesis, St. Petersburg (In Russian). Google Scholar7. LONNQVIST B: Beiträge zur Kenntnis der Magensaftabsonderung, Skand. Arch. f. Physiol., 1906, xviii, 194. CrossrefGoogle Scholar8. KAUDERSPORGES FO: Der Einfluss des Duodenalinhaltes auf die Magensekretion, Wien. klin. Wchnschr., 1922, xxxv, 838. Google Scholar9. ROBERTS WM: Some observations on the action of belladonna and neutral fats on the acidity of the stomach contents, Quart. Jr. Med., 1925-1926, xix, 74. CrossrefGoogle Scholar10. ROBERTS WM: The effect of oils on gastric secretion and motility, Quart. Jr. Med., 1931, xxiv, 133. CrossrefGoogle Scholar11. SHAYGERSHON-COHEN HJ: Experimental studies in gastric physiology. II. A study of pyloric control. The rôles of acid and alkali, Surg., Gynec. and Obst., 1934, lviii, 935. Google Scholar12. 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IVYMCILVAIN ACGB: The excitation of gastric secretion by application of substances to the duodenal and jejunal mucosa, Am. Jr. Physiol., 1923-1924, lxvii, 124. CrossrefGoogle Scholar20. SHAYKATZSCHLOSS HABEM: Experimental studies in gastric physiology. I. Evaluation of the rôle of duodenal regurgitation in the control of gastric acidity in man (Boldyreff Theory), Arch. Int. Med., 1932, l, 605. CrossrefGoogle Scholar21. MACLAGAN NF: Statistical analysis of 389 fractional test meals, with special reference to duodenal regurgitation, Quart. Jr. Med., 1934, iii, 321. Google Scholar22. TEORELL T: Untersuchungen über die Magensaftsekretion, Skand. Arch. f. Physiol., 1933, lxvi, 225. CrossrefGoogle Scholar23. HOLLANDER F: Personal communication. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Philadelphia, Pennsylvania*Received for publication October 10, 1938.From the Samuel S. Fels Fund and Gastro-Intestinal Division, Medical Service 1, Mt. Sinai Hospital.†Leviticus 7: 23.‡"How," asks Aristotle, "does the stomach come to digest fat meat slowly?" "Because," he answers, "it swims in the stomach. The best digestion takes place at the bottom of the stomach, where the fat does not descend. Those who eat fat meat are sleepy, because their digestion is hindered." 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