tbuckley/cabot-search huggingface dataset:
BAX protein expression and clinical outcome in epithelial ovarian cancer.
Authors: Y T Tai, S Lee, E Niloff, C Weisman, T Strobel, S A Cannistra
Journal: Journal of Clinical Oncology (1998)

PURPOSE Expression of the pro-apoptotic protein BAX sensitizes ovarian cancer cell lines to paclitaxel in vitro by enhancing the pathway of programmed cell death. The present study was performed to determine the relationship between BAX expression and clinical outcome in 45 patients with newly diagnosed ovarian cancer. METHODS BAX protein expression was analyzed by immunohistochemistry, and its relationship with clinical outcome was determined. Assessment of BAX mRNA transcript levels and mutational analysis of the BAX coding region were also performed. RESULTS BAX protein was expressed at high levels (defined as &gt; or = 50% of tumor cells positive) in tumor tissue from 60% of newly diagnosed patients. All patients whose tumors expressed high levels of BAX achieved a complete response (CR) to first-line chemotherapy that contained paclitaxel plus a platinum analogue, compared with 57% of patients in the low-BAX group (P = .036). After a median follow-up of 1.9 years, the median disease-free survival (DFS) of patients in the high-BAX group has not been reached, compared with a median DFS of 1.1 years for low-BAX expressors (P = .0061). BAX retained independent prognostic significance in multivariate analysis when corrected for stage and histology. BAX mRNA transcripts were easily detected in samples with low BAX protein expression, and no BAX mutations were identified. CONCLUSION The correlation between high BAX levels and improved clinical outcome suggests that an intact apoptotic pathway is an important determinant of chemoresponsiveness in ovarian cancer patients who receive paclitaxel.
Molecular and biological factors in the prognosis of non-small cell lung cancer
Authors: SD Kanters, JW Lammers, EE Voest
Journal: European Respiratory Journal (1995)

For patients with non-small cell lung cancer the tumour/node/metastasis (TNM) staging system and other conventional prognostic factors fail to predict the outcome of treatment and survival accurately. New prognostic factors are urgently needed to improve understanding of the biological behaviour of the different subtypes of non-small cell lung cancer and to recognize patients with a good or poor prognosis. This review will focus on molecular and biological factors published in the English language literature between 1988 and 1994. To be included in this survey, the predictive value of a specific prognostic factor had to be confirmed by multivariate analysis in at least two different studies. Blood group antigen expression, ras oncogenes, microvessel density, and factors reflecting the proliferative state of the tumour may be important determinants of outcome of treatment. The search for new determinants of prognosis has provided insight in the complex tumour biology of non-small cell lung cancer and indicated possible targets for tumour therapy. Several promising prognostic factors have now been recognized. To validate these factors, prospective studies of a large patient population are needed. This ultimately serves the recognition of subsets of patients who may benefit from adjuvant therapy.
Zero-Flow Pressures and Pressure-Flow Relationships during Single Long Diastoles in the Canine Coronary Bed before and during Maximum Vasodilation
Authors: Francis J. Klocke, Irwin R. Weinstein, James F. Klocke, Avery K. Ellis, David R. Kraus, Robert E. Mates, John M. Canty, Ran D. Anbar, Roslyn R. Romanowski, Kenneth W. Wallmeyer, Martin P. Echt
Journal: Journal of Clinical Investigation (1981)

The proposal that diastolic coronary flow is regulated by an intramyocardial "back-pressure" that substantially exceeds coronary venous and ventricular diastolic pressures has been examined in an open-chest canine preparation in which instantaneous left circumflex pressure and flow could be followed to cessation of inflow during prolonged diastoles. Despite correlation coefficients consistently >0.90, pressure-flow data during individual diastoles were concave to the flow axis before and during pharmacologically induced maximum coronary vasodilation. Data were better fitted (P < 0.01) by second-order equations than by linear equations in >90% of cases. Second-order pressure-axis intercepts (Pf=0)1 averaged 29±7 (SD) mm Hg before vasodilation and 15±2 mm Hg during vasodilation; left and right atrial pressures were always substantially lower (8±3 and 5±2 mm Hg before vasodilation and 8±2 and 4±1 mm Hg during dilation). Values of Pf=0 before vasodilation varied directly with levels of coronary inflow pressure. A modification of the experimental preparation in which diastolic circumflex pressure could be kept constant was used to evaluate the suggestion that Pf=0 measured during long diastoles are misleadingly high because of capacitive effects within the coronary circulation as inflow pressure decreases. Decreases in Pf=0 attributable to capacitive effects averaged only 5.9±3.0 mm Hg before vasodilation and were smaller during dilation. We conclude that Pf=0 is a quantitatively important determinant of coronary driving pressure and flow, resulting from both factors related to, and independent of, vasomotor tone. Adjustments of flow during changing physiological situations may involve significant changes in Pf=0 as well as in coronary resistance.
Effects of long-term breastfeeding and parental asthma condition on the prevalence and severity of asthma, rhinitis and eczema in schoolchildren from the United Arab Emirates
Authors: Mohammed Shamssain, Saeed Abdulla, Aya Lafta
Journal: European Respiratory Journal (2014)

There are few studies on the effects of long-term breast feeding and parental asthma condition on the prevalence and severity of asthma, rhinitis and eczema in schoolchildren. We studied 4026 schoolchildren from the UAE. We used the Arabic version of ISAAC questionnaire (the International Study of Asthma and Allergies in Childhood). The prevalence rates of ever rhinitis, ever eczema and ever asthma were 31.7%, 12.0% and 9.5%, respectively. Boys had significantly higher prevalence rates of rhinitis and asthma than girls ( 34.8% and 12.2% vs 29.4% and 7.4%, respectively). Girls had higher prevalence of eczema than boys (12.6% vs 11.2%). Children who breastfed for less than one year had significantly higher prevalence rates of asthma and rhinitis compared to those who breastfed more than one year (20.8% vs 15.0% and 20.7% vs 17.0%,respectively. The prevalence of ever asthma in children exposed to passive smoking was significantly higher than non-exposed children. High prevalence of asthma (43.3%) was found in children from both asthmatic parents compared to children from parents without asthma (7.9%). The prevalence of asthma in the present study was lower than the results obtain in 1994. The present study shows that breastfeeding more than 12 months has protective effect against asthma and allergic rhinitis. Therefore parent should be encouraged to breastfeed their children for at least 12 months. The present study confirms an improvement in asthma management in the UAE and doctors follow the international asthma management guidelines.
Cancer Stem Cells: Basic Concepts and Therapeutic Implications
Authors: Dany Nassar, Cédric Blanpain
Journal: Annual Review of Pathology Mechanisms of Disease (2016)

Different mechanisms contribute to intratumor heterogeneity, including genetic mutations, the microenvironment, and the existence of subpopulations of cancer cells with increased renewal capacity and the ability to recapitulate the heterogeneity found in primary tumors, which are referred to as cancer stem cells (CSCs). In this review, we discuss how the concept of CSCs has been defined, what assays are currently used to define the functional properties of CSCs, what intrinsic and extrinsic mechanisms regulate CSC functions, how plastic CSCs are, and the importance of epithelial-to-mesenchymal transition in conferring CSC properties. Finally, we discuss the mechanisms by which CSCs may resist medical therapy and contribute to tumor relapse.
Leukemia-Associated Antigens Detected by Heterologous Antisera 2
Authors: Alberto Durantez, Jacob Zighelboim, Robert Peter Gale
Journal: JNCI Journal of the National Cancer Institute (1976)

Journal Article Leukemia-Associated Antigens Detected by Heterologous Antisera Get access Alberto Durantez, Alberto Durantez Search for other works by this author on: Oxford Academic PubMed Google Scholar Jacob Zighelboim, Jacob Zighelboim Search for other works by this author on: Oxford Academic PubMed Google Scholar Robert Peter Gale Robert Peter Gale Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 56, Issue 6, June 1976, Pages 1217–1219, https://doi.org/10.1093/jnci/56.6.1217 Published: 01 June 1976 Article history Received: 15 September 1975 Accepted: 11 December 1975 Published: 01 June 1976
Validity of the fractional exhaled nitric oxide (FENO) for identification of bronchial hyperresponsiveness in a pulmonary function laboratory
Authors: Jorge Chancafe-Morgan, Yolanda Ramos-Quispe, Rosa Gomez-García, Julio Vargas-Espinal, Luis Puente-Maestú
Journal: European Respiratory Journal (2013)

Objective: To evaluate the validity of the Fractional Exhaled Nitric Oxide test (FENO) for identification of bronchial hyperresponsiveness.

Methods: We conducted a prospective, consecutive, observational study. Subjects who underwent a FENO and methacholine test (MT) for BH suspicion were included. The MT was the gold standard test. We assessed the cut-off point 35 ppb for a positive FENO result. We obtained the FENO sensitivity (S), specificity (E), positive predictive value (PPV) and negative predictive value (NPV). The data were analyzed with the SPSS 15 statistical program.

Results: A total of 30 subjects were included. The mean age was 44,2 years (SD 16,7) and 10 (33 %) were male. The mean FENO value was 33,6 (SD 18,7). Of them, 12 (40%) had a positive MT and 12 (40%) a positive FENO result. The S, E, PPV and NPV were 75%, 83,3%, 75% and 83,3 %.

Conclusions: According to our data, FENO seems to have a fairly good profile to predict MT results.
Effectiveness of a hospital-wide selective screening programme for methicillin-resistant Staphylococcus aureus (MRSA) carriers at hospital admission to prevent hospital-acquired MRSA infections
Authors: M.H. Wernitz, S. Swidsinski, K. Weist, D. Sohr, W. Witte, K-P. Franke, D. Roloff, H. Rüden, S.K. Veit
Journal: Clinical Microbiology and Infection (2005)
Consultants' workload in outpatient clinics
Authors: A. P Volans
Journal: BMJ (1995)

HSV-2 infection is a global, serious public health problem affecting over 530 million people. ACAM529, a vaccine candidate targeting genital herpes infections, is an HSV-2 virus rendered incapable of replication, through deletion of the genes UL5 and UL29. Blockage of viral DNA replication is expected to prevent true late gene expression, yet this vaccine successfully protected animals against infection and lethal challenge in preclinical studies (Delagrave et al., 2012, PLoS One, 7(10): e46714). Here we present the IgG responses against viral glycoproteins elicited by ACAM529 vaccination. We compare the ability of ACAM529 to generate IgG responses to gG and gD, two leaky late (γ1) HSV-2 antigens, and gC a true late antigen (γ2).
Efficacy and safety of thalidomide for the treatment of severe recurrent epistaxis in hereditary haemorrhagic telangiectasia: results of a non-randomised, single-centre, phase 2 study
Authors: Rosangela Invernizzi, Federica Quaglia, Catherine Klersy, Fabio Pagella, Federica Ornati, Francesco Chu, Elina Matti, Giuseppe Spinozzi, Sara Plumitallo, Pierangela Grignani, Carla Olivieri, Raffaella Bastia, Francesca Bellistri, Cesare Danesino, Marco Benazzo, Carlo L Balduini
Journal: The Lancet Haematology (2015)
Polyurethane: Stable Cell Phenotype Requires Plasticity: Polymer Supported Directed Differentiation Reveals a Unique Gene Signature Predicting Stable Hepatocyte Performance (Adv. Healthcare Mater. 12/2015)
Authors: Baltasar Lucendo Villarin, Kate Cameron, Dagmara Szkolnicka, Hassan Rashidi, Nicola Bates, Susan J. Kimber, Oliver Flint, Stuart J. Forbes, John P. Iredale, Mark Bradley, David C. Hay
Journal: Advanced Healthcare Materials (2015)

One major obstacle to the routine deployment of stem cell-derived cells is their instability in culture. On page 1820 David C. Hay and co-workers describe the use of a synthetic polymer surface. The image shows stem cell-derived hepatocytes replated on this polyurethane surface. Importantly the cells express Zonal Occludin (green stain) at the cell surface, which indicates that the cells display elements of polarization. The blue stain is DAPI, which demarks the nucleus.
Expression of PU.1 and autophagy of the macrophages treated with graphene oxide and their reductives
Authors: In Won Park, Jae Woo Jung, Jae Chol Choi, Jae Yeol Kim, Byoung Whui Choi, Chang Seok Park, Kyung Soon Choi, Joo Hyun Park, Soo Young Kim, Jong Wook Shin
Journal: European Respiratory Journal (2013)

Background: The graphene which is an allotrope of carbon has the honeycombing structure of one-atom-thick planar sheets. It can be produced by chemical vaporization device. For its unique chemicophysical properties, it is one of vast utilized material in 21th century in modern electronic, informatice technologies including medical device. Thus biohazards of graphene must be evaluated for industry people. We studied defining the graphene induced effects on immunologic function through investigation of PU.1, Autophagy of macrophages treated with graphene oxide and their reductives. Materials and Methods: Raw264.7 cells were cultured in DMEM(Dulbecco’s Modified Eagle’s Medium) with 10% fetal bovine serum. Graphene oxide(GO), reduced GO, sodium dodecyl amine GO and hydrazine amine GO. MTT was performed for cell proliferation assay. Western blots were done for expression of PU.1 and LC3B-I/LC3B-II. Results: R-GO, SDS-GO, DA-GO inhibited the proliferation of Raw264.7 cells but not GO in 24, 48 and 72 hours of treating duration. Those inhibition showed concentration-dependent manner. PU.1 expression was decreased with treatment of 4 forms of GO. Autophagy checked by conversion from LC3B-I to LC3B-II was induced by all the forms of GO. Conclusion: GO and its derivatives can inhibit proliferation and induce autophagy of macrophages. They also suppress expression of PU.1. Further evaluation for association between PU.1 and autophagy may be necessary.

Acknowledgement: This research was supported by Mid-career Research Program (2011-0028752) through the National Research Foundation of Korea (NRF) funded by the Ministry of Education, Science and Technology.
Tumor Induction in Squirrel Monkeys by the ST Strain of Feline Sarcoma Virus&lt;xref ref-type="fn" rid="FN1"&gt;2&lt;/xref&gt;
Authors: H Rabin, G H Theilen, P S Sarma, D L Dungworth, W A Nelson-Rees, R W Cooper
Journal: JNCI Journal of the National Cancer Institute (1972)

Journal Article Tumor Induction in Squirrel Monkeys by the ST Strain of Feline Sarcoma Virus Get access Harvey Rabin, Harvey Rabin Search for other works by this author on: Oxford Academic PubMed Google Scholar Gordon H. Theilen, Gordon H. Theilen Search for other works by this author on: Oxford Academic PubMed Google Scholar Padman S. Sarma, Padman S. Sarma Search for other works by this author on: Oxford Academic PubMed Google Scholar Donald L. Dungworth, Donald L. Dungworth Search for other works by this author on: Oxford Academic PubMed Google Scholar Walter A. Nelson-Rees, Walter A. Nelson-Rees Search for other works by this author on: Oxford Academic PubMed Google Scholar Robert W. Cooper Robert W. Cooper Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 49, Issue 2, August 1972, Pages 441–450, https://doi.org/10.1093/jnci/49.2.441 Published: 01 August 1972 Article history Received: 21 January 1972 Accepted: 31 March 1972 Published: 01 August 1972
Treatment strategies for coronary in-stent restenosis: systematic review and hierarchical Bayesian network meta-analysis of 24 randomised trials and 4880 patients
Authors: Daniele Giacoppo, Giuseppe Gargiulo, Patrizia Aruta, Piera Capranzano, Corrado Tamburino, Davide Capodanno
Journal: BMJ (2015)

<b>Study question</b> What is the most safe and effective interventional treatment for coronary in-stent restenosis? <b>Methods</b> In a hierarchical Bayesian network meta-analysis, PubMed, Embase, Scopus, Cochrane Library, Web of Science, ScienceDirect, and major scientific websites were screened up to 10 August 2015. Randomised controlled trials of patients with any type of coronary in-stent restenosis (either of bare metal stents or drug eluting stents; and either first or recurrent instances) were included. Trials including multiple treatments at the same time in the same group or comparing variants of the same intervention were excluded. Primary endpoints were target lesion revascularisation and late lumen loss, both at six to 12 months. The main analysis was complemented by network subanalyses, standard pairwise comparisons, and subgroup and sensitivity analyses. <b>Study answer and limitations</b> Twenty four trials (4880 patients), including seven interventional treatments, were identified. Compared with plain balloons, bare metal stents, brachytherapy, rotational atherectomy, and cutting balloons, drug coated balloons and drug eluting stents were associated with a reduced risk of target lesion revascularisation and major adverse cardiac events, and with reduced late lumen loss. Treatment ranking indicated that drug eluting stents had the highest probability (61.4%) of being the most effective for target lesion vascularisation; drug coated balloons were similarly indicated as the most effective treatment for late lumen loss (probability 70.3%). The comparative efficacy of drug coated balloons and drug eluting stents was similar for target lesion revascularisation (summary odds ratio 1.10, 95% credible interval 0.59 to 2.01) and late lumen loss reduction (mean difference in minimum lumen diameter 0.04 mm, 95% credible interval −0.20 to 0.10). Risks of death, myocardial infarction, and stent thrombosis were comparable across all treatments, but these analyses were limited by a low number of events. Trials had heterogeneity regarding investigation periods, baseline characteristics, and endpoint reporting, with a lack of information at long term follow-up. Direct and indirect evidence was also inconsistent for the comparison between drug eluting stents and drug coated balloons. <b>What this study adds</b> Compared with other currently available interventional treatments for coronary in-stent restenosis, drug coated balloons and drug eluting stents are associated with superior clinical and angiographic outcomes, with a similar comparative efficacy. <b>Funding, competing interests, data sharing</b> This study received no external funding. The authors declare no competing interests. No additional data available.
Complex Autism Spectrum Disorders and Cutting-Edge Molecular Diagnostic Tests
Authors: Judith H. Miles
Journal: JAMA (2015)

Kristiina Tammimies, PhD; Christian R. Marshall, PhD; Susan Walker, PhD; Gaganjot Kaur, MRes; Bhooma Thiruvahindrapuram, MSc; Anath C. Lionel, PhD; Ryan K. C. Yuen, PhD; Mohammed Uddin, PhD; Wendy Roberts, MD; Rosanna Weksberg, MD-PhD; Marc Woodbury-Smith, MD-PhD; Lonnie Zwaigenbaum, MD; Evdokia Anagnostou, MD; Zhuozhi Wang, PhD; John Wei, PhD; Jennifer L. Howe; Matthew J. Gazzellone, MSc; Lynette Lau, MSc; Wilson W. L. Sung, MSc; Kathy Whitten; Cathy Vardy, MD; Victoria Crosbie, MD; Brian Tsang, BSc; Lia D’Abate, BSc; Winnie W. L. Tong; Sandra Luscombe, MD; Tyna Doyle, MD; Melissa T. Carter, MD; Peter Szatmari, MD; Susan Stuckless, PhD; Daniele Merico, PhD; Dimitri J. Stavropoulos, PhD; Stephen W. Scherer, PhD; Bridget A. Fernandez, MD
Influence of Ehrlich Ascites Carcinoma on Repopulating Ability of Mouse Bone Marrow Cells&lt;xref ref-type="fn" rid="FN1"&gt;2&lt;/xref&gt;
Authors: Enrico Clerici, Paolo Mocarelli, Maria Luisa Villa, Nicola Natale
Journal: JNCI Journal of the National Cancer Institute (1971)

In one experiment, adult mice inoculated intraperitoneally with Ehrlich ascites carcinoma cells and then exposed to sublethal X irradiation developed significantly fewer “endogenous” spleen colonies than X-irradiated controls not inoculated with tumor cells. In another experiment, results were similar when bone marrow cells from tumor-bearing mice were injected intravenously into lethally X-irradiated mice to produce “exogenous” spleen colonies. In both experiments, the inoculum of Ehrlich ascites carcinoma cells necessary to reduce significantly the frequency of hematopoietic stem cells was found to be 8.5 × 105 cells-the number of tumor cells that inhibits the immune reactivity of host mice. These findings are consistent with our working hypothesis that the immunologic hyporeactivity of tumor-bearing animals is mediated through a functional defect of primitive bone marrow cells. Such a mechanism of action, similar to that recently proposed for Friend leukemia virus and for the chemical carcinogen 7,12-dimethylbenzlalanthracene, suggests a common pathway for the immunosuppression caused by malignant tumors.
Ataque de nervios and panic disorder
Authors: M R Liebowitz, E Salmán, C M Jusino, R Garfinkel, L Street, D L Cárdenas, J Silvestre, A J Fyer, J L Carrasco, S Davies
Journal: American Journal of Psychiatry (1994)

Ataque de nervios ("attack of nerves") is an illness category used frequently by Hispanic individuals to describe one or more particular symptom complexes. A review of the literature on ataque suggested some overlap with panic disorder. This study investigated the overlap with panic disorder as well as other DSM-III-R axis I disorders.Hispanic subjects seeking treatment at an anxiety disorders clinic (N = 156) were assessed with a specially designed questionnaire for self-report of ataque de nervios and panic symptoms and with structured or semistructured psychiatric interviews for axis I disorders.Seventy percent of the subjects reported at least one ataque de nervios; 80% of these were female, whereas 57% of the group without these attacks were female. There were no differences in DSM-III-R diagnoses between the groups with and without ataque de nervios. Ataque was frequently associated with one or more anxiety and affective disorders, including panic disorder, generalized anxiety disorder, recurrent major depression, and anxiety not otherwise specified. Of the 45 subjects with both ataque de nervios and primary panic disorder, 80% appeared to have labeled panic disorder as ataque. Ataque de nervios was associated with panic symptoms even in subjects without panic disorder, but the self-reporting of ataque conveyed additional clinical information about the subjects with panic disorder. Ataque de nervios was similar in frequency and symptoms among subjects of Dominican and Puerto Rican origin.Ataque de nervios overlaps with panic disorder but is a more inclusive construct. Further study of its interrelation with axis I disorders is needed.