AN ANAPHYLACTIC REACTION TO SODIUM DEHYDROCHOLATE (DECHOLIN)
Authors: J P ELLIOTT, R VIDRINE, A M GOLDMAN
Journal: Annals of Internal Medicine (1960)

Case Reports1 December 1960AN ANAPHYLACTIC REACTION TO SODIUM DEHYDROCHOLATE (DECHOLIN)JOHN P. ELLIOTT JR., M.D., RANSOM VIDRINE, M.D., ALLAN M. GOLDMAN, M.D., F.A.C.PJOHN P. ELLIOTT JR., M.D., RANSOM VIDRINE, M.D., ALLAN M. GOLDMAN, M.D., F.A.C.PAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-53-6-1228 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptDecholin is a sodium salt of dehydrocholic acid, an oxidative product of cholic acid, which is derived from the natural bile salts.Since Winternitz introduced the use of Decholin in the measurement of circulation time in 1931, its usefulness has been both substantial and well documented.10, 5, 9 It is recommended not only for determination of circulation time, but for treatment of penicillin reactions, as a diuretic, and for its hydrochlororetic action in cholangitis and postoperative cholecystectomies.It is considered to be the least toxic of all the bile salts in man,1, 12although a 2% solution will stop the...Bibliography1. Horrall OH: Bile, its toxicity and relation to disease, 1938, University of Chicago Press, Chicago. CrossrefGoogle Scholar2. Winternitz MC: Toxic reactions to sodium dehydrocholate, Lancet 1: 295-296 (Feb. 26) 1944. CrossrefGoogle Scholar3. BowerMengle JOHA: Additive effect of calcium and digitalis; warning with report of two deaths, J. A. M. A. 106: 1151-1153 (Apr. 4) 1936. CrossrefGoogle Scholar4. Leys DG: Toxic reactions to sodium dehydrocholate, Brit. M. J. 1: 198 (Feb. 5) 1944. CrossrefGoogle Scholar5. Norman J: Reactions to Decholin in circulation time determinations, Am. Heart J. 34: 740-742 (Nov.) 1947. CrossrefMedlineGoogle Scholar6. CogginsSkinnerBurrell RPJMZL: Anaphylactoid reaction to sodium dehydrocholate; case report, New England J. Med. 249: 154-155 (July 23) 1953. CrossrefMedlineGoogle Scholar7. ArmaninoScott LPWS: Anaphylactic shock following intravenous thiamine chloride; report of a case, California Med. 72: 178-179 (Mar.) 1950. MedlineGoogle Scholar8. Suckle E: Allergic reaction to Decholin used in circulation test, California Med. 72: 119-120 (Feb.) 1950. MedlineGoogle Scholar9. Hitzig WM: Value of circulation times, Mod. Concepts Cardiovas. Dis. 16: (Aug.) 1947. Google Scholar10. TarrOppenheimerSager LBSR: The circulation time in various clinical conditions determined by the use of sodium dehydrocholate, Am. Heart J. 8: 766-786 (Aug.) 1933. CrossrefGoogle Scholar11. GrodinsBermanIvy FSALAC: Observations on toxicities and choleretic activities of certain bile salts, J. Lab. and Clin. Med. 27: 181-186 (Nov.) 1941. Google Scholar12. Owen G: Sodium Decholin treatment of penicillin reaction, South. M. J. 48: 846-848 (Aug.) 1955. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: JOHN P. ELLIOTTJR., M.D.; RANSOM VIDRINE, M.D.; ALLAN M. GOLDMAN, M.D., F.A.C.PAffiliations: New Orleans, Louisiana*Received for publication January 25, 1960.From the Department of Medicine, Touro Infirmary, New Orleans, Louisiana.Requests for reprints should be addressed to Allan M. Goldman, M.D., 203 Medical Arts Building, New Orleans, Louisiana. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byANAPHYLACTIC REACTIONS FROM SHELLFISHAnaphylaxis 1 December 1960Volume 53, Issue 6Page: 1228-1232KeywordsAllergy and immunologyAmnesiaAnaphylaxisBileCholecystectomyDiureticsEpileptic seizuresPenicillinSaltsSodium ePublished: 1 December 2008 Issue Published: 1 December 1960 PDF downloadLoading ...