tbuckley/cabot-search huggingface dataset:
Human smooth muscle myosin heavy chain isoforms as molecular markers for vascular development and atherosclerosis.
Authors: M Aikawa, P N Sivam, M Kuro-o, K Kimura, K Nakahara, S Takewaki, M Ueda, H Yamaguchi, Y Yazaki, M Periasamy
Journal: Circulation Research (1993)

Smooth muscle myosin heavy chains (MHCs) exist in multiple isoforms. Rabbit smooth muscles contain at least three types of MHC isoforms: SM1 (204 kD), SM2 (200 kD), and SMemb (200 kD). SM1 and SM2 are specific to smooth muscles, but SMemb is a nonmuscle-type MHC abundantly expressed in the embryonic aorta. We recently reported that these three MHC isoforms are differentially expressed in rabbit during normal vascular development and in experimental arteriosclerosis and atherosclerosis. The purpose of this study was to clarify whether expression of human smooth muscle MHC isoforms is regulated in developing arteries and in atherosclerotic lesions. To accomplish this, we have isolated and characterized three cDNA clones from human smooth muscle: SMHC94 (SM1), SMHC93 (SM2), and HSME6 (SMemb). The expression of SM2 mRNA in the fetal aorta was significantly lower as compared with SM1 mRNA, but the ratio of SM2 to SM1 mRNA was increased after birth. SMemb mRNA in the aorta was decreased after birth but appeared to be increased in the aged. To further examine the MHC expression at the histological level, we have developed three antibodies against human SM1, SM2, and SMemb using the isoform-specific sequences of the carboxyl terminal end. Immunohistologically, SM1 was constitutively positive from the fetal stage to adulthood in the apparently normal media of the aorta and coronary arteries, whereas SM2 was negative in fetal arteries of the early gestational stage. In human, unlike rabbit, aorta or coronary arteries, SMemb was detected even in the adult. However, smaller-sized arteries, like the vasa vasorum of the aorta or intramyocardial coronary arterioles, were negative for SMemb. Diffuse intimal thickening in the major coronary arteries was found to be composed of smooth muscles, reacting equally to three antibodies for MHC isoforms, but reactivities with anti-SM2 antibody were reduced with aging. With progression of atherosclerosis, intimal smooth muscles diminished the expression of not only SM2 but also SM1, whereas alpha-smooth muscle actin was well preserved. We conclude from these results that smooth muscle MHC isoforms are important molecular markers for studying human vascular smooth muscle cell differentiation as well as the cellular mechanisms of atherosclerosis.
Scintigraphic Detection of Prosthetic Joint and Soft Tissue Sepsis Secondary to Tuberculosis
Authors: LOUIS S. ZEIGER, WILLIAM WATTERS, HENRY SHERK
Journal: Clinical Nuclear Medicine (1984)

In a 40–year–old Hispanic woman with pain and swelling in the left knee with a prosthesis, the combination of Ga–67 citrate and Tc–99m methylene diphosphonate (MDP) scans was used to indicate that there was a septic prosthetic joint. At surgery, the joint was infected and a foreign body was found. Cultures positive for tuberculosis were found also. The presence of an incongruent Ga–67 and Tc–99m (MDP) scan pattern suggests infection of the prosthetic joint, as in the following case.
Changing Use of Hospital Beds by the Elderly
Authors: R. W. Parnell, K. W. Cross, M. Wall
Journal: BMJ (1968)

Recent changes in the age structure of the mental hospital population in the Birmingham Region are first examined. The proportion of patients aged 65 and over of the total in residence has steadily increased and at the end of 1967 was 43%, and more than half the female patients are now in this age group.Admissions of elderly persons to both psychiatric and general hospitals have increased, and these hospitals have responded to the increased demand on their services by increasing bed-turnover rates. During 1967 on average one-fifth of all patients occupying beds for acute cases (excluding maternity) were 65 years of age or over.In the geriatric hospital service, on the other hand, accommodation per head of the population decreased between 1961 and 1967, as did the total annual number of admissions and the rate of turnover. This suggests that the geriatric service is overstretched and that it is under-organized, understaffed, or undercapitalized-possibly all three. The enforced expedient of admitting "excess" elderly patients to mental hospitals does not recommend itself.
Monoclonal gammopathy in extranodal marginal zone lymphoma (ENMZL) correlates with advanced disease and bone marrow involvement
Authors: Ekatherine Asatiani, Philip Cohen, Metin Ozdemirli, Craig M. Kessler, Blanche Mavromatis, Bruce D. Cheson
Journal: American Journal of Hematology (2004)

Monoclonal gammopathy is a well-recognized occurrence in splenic marginal zone lymphoma (MZL); however, its prevalence has never been reported in extranodal MZL (ENMZL). We present results of a retrospective analysis of 26 patients with newly diagnosed as well as previously treated ENMZL. Monoclonal gammopathy was detected in 7 out of 26 (27%) patients. All patients with a monoclonal gammopathy had stage IV disease, and most of them had involvement of lymph nodes and/or bone marrow (n = 6). Only 1 out of 7 patients with a monoclonal spike had stage IV disease diagnosed based on multifocal mucosal involvement. There was also a strong correlation between the involvement of bone marrow and the presence of a monoclonal spike (Fisher's exact test, P = 0.0007). Prevalence of monoclonal gammopathy is higher than previously recognized and indicates advanced disease. However, the prognostic significance of the presence of monoclonal gammopathy in this population is unknown.
Single-Agent Rituximab as First-Line and Maintenance Treatment for Patients With Chronic Lymphocytic Leukemia or Small Lymphocytic Lymphoma: A Phase II Trial of the Minnie Pearl Cancer Research Network
Authors: John D. Hainsworth, Sharlene Litchy, John H. Barton, Gerry Ann Houston, Robert C. Hermann, James E. Bradof, F. Anthony Greco
Journal: Journal of Clinical Oncology (2003)

Purpose: To assess the efficacy and toxicity of first-line single-agent rituximab, followed by re-treatment with rituximab at 6-month intervals, in previously untreated patients with chronic lymphocytic leukemia (CLL) or small lymphocytic lymphoma (SLL). Patients and Methods: Forty-four previously untreated patients with CLL/SLL received rituximab 375 mg/m 2 weekly for 4 consecutive weeks. All patients were required to have one or more indications for treatment. Patients with objective response or stable disease continued to receive identical 4-week rituximab courses at 6-month intervals, for a total of four courses. Results: The objective response rate after the first course of rituximab was 51% (4% complete responses). Twenty-eight patients received one or more additional courses of rituximab. At present, the overall response rate is 58%, with 9% complete responses. After a median follow-up of 20 months, the median progression-free survival (PFS) time was 18.6 months, and the 1- and 2-year PFS rates were 62% and 49%, respectively. Treatment was well tolerated, with only two episodes of grade 3 to 4 infusion-related toxicity. No cumulative toxicity or opportunistic infections occurred. Conclusion: Single-agent rituximab, used at a standard dose and schedule, is active in the first-line treatment of patients with CLL/SLL, producing substantially higher response rates than previously reported in relapsed or refractory patients (51% v 13%, respectively). Re-treatment with rituximab at 6-month intervals is well tolerated. The PFS time of 18.6 months in patients with CLL/SLL seems shorter than the 36- to 40-month median PFSs previously reported with first-line plus maintenance rituximab in patients with follicular lymphoma. Additional follow-up is required to fully assess the impact of this treatment strategy.
A PLEA FOR THE GENERAL ADOPTION OF THE AXIS-TRACTION FORCEPS.Read in the Section of Obstetrics and Diseases of Women at the Forty-first Annual Meeting of the American Medical Association, at Nashville, Tenn., May, 1890.
Authors: JOSEPH HOFFMAN
Journal: JAMA (1890)

In presenting any question concerning the forceps I am well aware that I am treading upon hackneyed ground. Without preface I shall hasten to the statement of my argument for the adoption of the axis-traction forceps. First of all, the use of the forceps is to be considered as an<i>obstetric procedure</i>, which before employment, is to be fully justified, both in the interests of the mother and of the child, entirely apart from the convenience or prejudice of the operator. The forceps are to be applied, neither because the mother demands them nor because they are a time-saving convenience for the obstetrician. Their use is strictly a logical one, and must be differentiated from every fallacy of apparent justification. The question has been asked, Can there be a too frequent use of the obstetric forceps? On the other hand, we hear continually of the "abuse" of the instrument. Now,
Training Programs in Medical Oncology
Authors: B.J. Kennedy, Paul Calabresi, Bayard Clarkson, Eugene Frenkel
Journal: Annals of Internal Medicine (1986)

Letters and Corrections1 February 1986Training Programs in Medical OncologyB.J. KENNEDY, M.D., PAUL CALABRESI, M.D., BAYARD CLARKSON, M.D., EUGENE FRENKEL, M.D.B.J. KENNEDY, M.D.Search for more papers by this author, PAUL CALABRESI, M.D.Search for more papers by this author, BAYARD CLARKSON, M.D.Search for more papers by this author, EUGENE FRENKEL, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-104-2-279_1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: The evolution of medical oncology has had a significant impact on cancer education, cancer research, and care of patients with cancer. Concern has been expressed regarding the potential overproduction of trained oncologists. Our survey has concluded that with 2975 oncologists already certified and with over 1000 trainees eligible for the 1985 and 1987 certifying examinations, by 1990 there will be no deficiency of oncologists. The American Society of Clinical Oncology has issued a position statement emphasizing that training in medical oncology should be of high quality, providing clinical investigation and career training for academic oncologists. To ensure... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Committee on Accreditation of Medical Oncology Training Programs American Society of Clinical Oncology Chicago, IL 60611 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByMedical oncology 1 February 1986Volume 104, Issue 2Page: 279-279KeywordsMedical educationPatients Issue Published: 1 February 1986 PDF DownloadLoading ...
Ganglion cell changes in experimental stenosis of the gut
Authors: R. J. Earlam
Journal: Gut (1971)

Teflon mesh was wrapped around the terminal ileum of dogs to cause a partial obstruction. Both smooth muscle layers became thickened in the gut proximal to the constriction, but the circular muscle was more hypertrophied than the longitudinal. The cells in Auerbach's plexus were stained by an indoxyl esterate technique in 100mu sections and counted. The number of ganglion cells related to muscle mass was decreased above the constriction. Although some ganglion cells increased in size there was no evidence of any increase in number.
REPORTS ON TYPHOID FEVER.
Authors: J. E. WOODBRIDGE
Journal: JAMA (1895)

I quote this letter from Dr. Balmer of Pennsylvania: "I have treated a number of cases of typhoid fever this summer, by your method, with remarkable success and will endeavor to copy the temperature charts and send them to you soon. I presented these cases and the method of treatment before our (the Jefferson County (Pa.) Medical Society, at the last meeting and I had introduced it previously orally in the society and to individual members. Dr. S. M. Free of DuBois, Pa., one of our members, is very enthusiastic, also Dr. J. J. Brewer of Clarington, Pa., who treated a number of patients by the method, at my suggestion." I very soon received a letter from Dr. S. M. Free of DuBois, dated December 26: "I have used your plan of treatment in a few cases of typhoid fever. It is the best I have ever employed. I have
FUNCTIONAL MITRAL REGURGITATION PERSISTENCE FOLLOWING ISOLATED AORTIC VALVE REPLACEMENT: THE ROLE OF PROSTHESIS-PATIENT MISMATCH
Authors: Emiliano Angeloni, Giovanni Melina, Philippe Pibarot, Umberto Benedetto, Elisabetta Giorni, Simone Refice, Riccardo Sinatra, John R. Pepper
Journal: Journal of the American College of Cardiology (2011)
Relapsing Polychondritis With Glomerulonephritis
Authors: James L. Ruhlen
Journal: JAMA (1981)

A 32-year-old man presented with relapsing polychondritis (RP) and microhematuria. A renal biopsy specimen disclosed focal segmental glomerulonephritis with occasional crescents. Immunofluorescent and electron micrographic studies suggested immune complex—mediated glomerular injury. Initially, life-threatening upper airway obstruction responded to high-dose corticosteroid therapy. Subsequently, progressive renal insufficiency and proteinuria caused by increasingly active glomerulonephritis were treated by adding cyclophosphamide, with sustained improvement. This case supports the concept that RP is an immunologically mediated disease and suggests that a regimen of prednisone and cyclophosphamide warrants consideration for use in cases of RP with glomerulonephritis. (<i>JAMA</i>1981;245:847-848)
Is Bias Inherent in HCFA-Sponsored Research?-Reply
Authors: Judith Garrard
Journal: JAMA (1991)

In Reply.  —We appreciate Rollings' concerns regarding the nature of the relationship between the HCFA and the HCFA Research Center at the University of Minnesota. This research project1was based on investigator-initiated research questions and methods on a topic of national health care policy. A high frequency of inadequate documentation to justify use of neuroleptics in patients in nursing homes was the major finding of this independent and unbiased scientific study. The staff of HCFA did not review or alter the manuscript before or after its submission for publication. The article includes a statement that the views expressed in our article are not necessarily those of the HCFA. Similarly, we take no responsibility for and do not necessarily agree with the statements made in the accompanying editorial.2We believe that the role of the AMA in meeting the needs of its physician members is aided, not precluded, by
Complement and the damaging effects of cardiopulmonary bypass.
Authors: S Westaby
Journal: Thorax (1983)

Complement and the damaging effects of cardiopulmonary bypass* "One of the most serious difficulties encountered in total body perfusion is the profound effect upon the lungs that may occur in certain patients.It is indeed discouraging to perform open cardiac corrective surgery, to have the patient remain in excellent condition throughout the procedure and for a day or two thereafter, finally succumbing to pulmonary insufficiency while the heart itself remains strong to the very end."F D DODRILI, Chicago, September 1957This statement opened the session on "postperfusion pulmonary dysfunction" at one of the first major international meetings devoted to the subject of cardiopulmonary bypass.Now, after 25 years of research and development in oxygenation and extracorporeal circulation, it is still apparent that adverse effects occur in every patient and continue to limit the scope of cardiac surgery as it could be practised today.In adult practice the full-blown clin- ical syndrome of haemorrhagic pulmonary oedema, fever, haemolysis, renal dysfunction, and abnormal bleeding is rarely seen.The typical patient leaves the intensive care unit after 12-24 hours and is ready for home in little more than a week.In the first three months of life, however, there is a considerable dif- ference in the results of cardiac surgery between patients who do and do not require cardiopulmonary bypass.'Thus it is still safer to construct a shunt in a small infant with tetralogy of Fallot than to perform complete correction.2There is no surgical reason for this and similar numbers of infants are ill in the two groups, but many deaths after total correction are attributable not to cardiac failure but to pulmonary problems, bleeding disorders, and other complications, which make us believe that the limi- tation to successful surgery is the "dose" of cardiopulmonary bypass.In fact, in the mid-1950s Lil- lehei and colleagues at the University of Minnesota
An Annual Epidemic of Acute Enteritis Associated with a High Incidence of Prolonged Malabsorption.
Authors: Thomas C. Jones
Journal: Annals of Internal Medicine (1969)

s1 May 1969An Annual Epidemic of Acute Enteritis Associated with a High Incidence of Prolonged Malabsorption.Thomas C. Jones, Gerald W. ParkerThomas C. JonesSearch for more papers by this author, Gerald W. ParkerSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-70-5-1068_1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptAn epidemic of acute nonbacterial gastroenteritis occurs annually at Clark Air Base causing significant morbidity among Americans living in the Philippines. It commences with the rainy season and affects 10 to 30% of the population. The cause remains unknown. During the epidemic in 1968, 190 patients with diarrhea were interviewed and evaluated for intestinal dysfunction. One hundred nineD-xylose tests, 25 lactose tolerance tests, 21 small-bowel series, and 18 peroral small-bowel biopsies were performed. Patients were observed for clinical signs of chronic enteritis or malabsorption. Two thirds of the patients tested with symptoms less than 14 days showedD-xylose malabsorption... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: USAF MC Republic of the Philippines PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 May 1969Volume 70, Issue 5Page: 1068-1068KeywordsBiopsyDiarrheaEnteritisGastroenteritisLactoseMorbidityPatientsXylose Issue Published: 1 May 1969 PDF DownloadLoading ...
Abuse of an Euphoretic Combination
Authors: C. A. Shamoian
Journal: JAMA (1969)

To the Editor:—  Glutethimide (Doriden), which is chemically related to thalidomide, has been prescribed widely for its sedative and hypnotic effects on psychiatric patients. This drug can cause toxic effects, addiction, and death from an overdosage; furthermore, its sudden cessation can cause withdrawal symptoms in an addict. Although glutethimide is usually used alone or occasionally with psychoactive drugs, to the best of our knowledge, a combination of codeine and glutethimide to induce and prolong euphoria has not been reported. The case reported here may illustrate incipient widespread abuse of a new euphoretic combination.  Report of a Case:—  A 24-year-old single, white man was admitted for glutethimide addiction and paranoid delusions. Abuse of drugs began at age 17 with 3 to 4 oz of cough medicine containing 180 to 240 mg of codeine (Robitussin A-C) daily for kicks. It was later supplemented with 1.5 to 2 gm of glutethimide to increase
OPERATIVE TREATMENT OF CERTAIN FRACTURES OF LONG BONES
Authors: JOHN J. MOORHEAD
Journal: JAMA (1923)

It is generally conceded that the "closed," or nonoperative, method of dealing with certain fractures is so unsatisfactory and uncertain that in selected cases "open" or operative reduction is justifiable. To avoid operating in that class of case in which closed reduction is impossible, resort is frequently made to skeletal traction by use of the tongs (calipers), a transfixion nail, or a metal band (stirrup). This procedure of skeletal traction is, strictly speaking, an "open" or operative method; but, because the procedure is relatively simple, requiring a small incision, it is finding increasing favor and is properly regarded as an intermediate method between "closed" and "open" reduction. For the purpose of selecting a type of treatment in my own services we have for some time divided all fractures into two general "types," either of which may be simple (closed) or compound (open). Type 1 is that group in which the
IL-17's tumor team
Authors: Amy Maxmen
Journal: The Journal of Experimental Medicine (2009)

In cancer, tumors may skew a cytokine tug-of-war to favor their own growth and survival, according to Wang et al. on [page 1457][1].

![Figure][2] 

Without IL-17, STAT3 levels drop, slowing tumor growth and spread (arrows).



The signature Th1 cytokine IFN-γ is a well-known tumor antagonist
Radioactivity in Man: Whole Body Counting and Effects of Internal Gamma Ray-Emitting Radioisotopes
Authors: Paul M. Meadows
Journal: JAMA (1966)

This book records a symposium on the problems of measuring lowlevel gamma isotopes. It will interest primarily those possessing or about to possess total-body gamma counters. That total-body counting has a great future is attested to by the presence of 129 expert contributors with 13 well-known chairmen.  The organization of the book is unusual with 11 forewords, one introduction, and five prefaces that cover 41 pages. The remaining 585 pages contain 43 separate articles with 12 discussions covering instrumentation, techniques, and calibration, together with 100 pages on body potassium, 90 pages on cobalt metabolism, and miscellaneous subjects such as iron metabolism and fission products. We can sympathize with the editors, trying to edit the tape of such lengthy proceedings, but we cannot understand the compulsion to print every last work uttered. If superfluous material were deleted, the book would be much better, and somewhat shorter.  Many interesting points on the
PRODUCTION IN MONKEYS OF COMPLEMENT-FIXING ANTIBODIES WITHOUT ACTIVE IMMUNITY BY INJECTION OF KILLED PLASMODIUM KNOWLESI
Authors: Monroe D. Eaton, L. T. Coggeshall
Journal: The Journal of Experimental Medicine (1939)

Injection into rhesus monkeys of Plasmodium knowlesi killed by heat, formalin, drying, or freezing and thawing stimulates the production of complement-fixing antibodies, but no demonstrable agglutinating or protective antibodies are formed. Possible differences in the immunity mechanisms concerned in active infection and in artificial immunization are discussed.
Serum paraoxonase activity and its relationship to diabetic complications in patients with non—insulin-dependent diabetes mellitus
Authors: Yukio Ikeda, Tadashi Suehiro, Mari Inoue, Yuh Nakauchi, Tatsuhito Morita, Kaoru Arii, Hiroyuki Ito, Yoshitaka Kumon, Kozo Hashimoto
Journal: Metabolism (1998)
Impact of early transcranial Doppler screening and intensive therapy on cerebral vasculopathy outcome in a newborn sickle cell anemia cohort
Authors: Françoise Bernaudin, Suzanne Verlhac, Cécile Arnaud, Annie Kamdem, Sylvie Chevret, Isabelle Hau, Lena Coïc, Emmanuella Leveillé, Elisabeth Lemarchand, Emmanuelle Lesprit, Isabelle Abadie, Nadia Medejel, Fouad Madhi, Sophie Lemerle, Sandra Biscardi, Josiane Bardakdjian, Frédéric Galactéros, Martine Torres, Mathieu Kuentz, Christelle Ferry, Gérard Socié, Philippe Reinert, Christophe Delacourt
Journal: Blood (2010)
Allelic methylation levels of the noncoding VTRNA2-1 located on chromosome 5q31.1 predict outcome in AML
Authors: Marianne Bach Treppendahl, Xiangning Qiu, Alexandra Søgaard, Xiaojing Yang, Cecilie Nandrup-Bus, Christoffer Hother, Mette Klarskov Andersen, Lars Kjeldsen, Lars Möllgaard, Eva Hellström-Lindberg, Johan Jendholm, Bo T. Porse, Peter A. Jones, Gangning Liang, Kirsten Grønbæk
Journal: Blood (2011)