tbuckley/cabot-search huggingface dataset:
Mandatory Reporting of Diseases and Conditions by Health Care Professionals and Laboratories
Authors: S Roush, G Birkhead, D Koo, A Cobb, D Fleming
Journal: JAMA (1999)

Surveillance is a key component of the core public health function of health assessment. Systematic reporting by health care professionals and laboratories, which may vary by state law, statute, or regulation, continues to provide essential data for assessing public health.To describe the state and territorial reporting requirements for diseases and conditions recommended for national public health surveillance.Between May and August 1997, the state and territorial epidemiologists from all 50 states, in addition to New York City, Puerto Rico, and Guam, completed questionnaires indicating which diseases and conditions were reportable by health care professionals and laboratories in their jurisdictions. The surveys were subsequently updated to reflect reporting requirements current as of January 1, 1999. The overall response rate for the survey was 100% for US states and 90% overall, including the territories.State and territorial reporting requirements for diseases and conditions of public health concern.Of the 58 diseases and conditions recommended for national reporting, 35 (60%) were reportable in greater than 90% of the states and territories, 15 (26%) were reportable in 75% to 90%, and 8 (14%) were reportable in less than 75%. Nineteen of the infectious diseases were reportable in all of the states and territories that responded.Required reporting varies substantially by state or territory. Health care professionals are integral to public health efforts at the local, state, and national levels.
Abstract P415: Multivitamin Use and the Risk of Cardiovascular Disease in Men
Authors: Susanne Rautiainen, Robert J Glynn, Julie E Buring, J. Michael Gaziano, Howard D Sesso
Journal: Circulation (2014)

Background: Although multivitamins are widely used by US adults, few prospective studies have investigated their association with the long- and short-term risk of cardiovascular disease (CVD). The aim of this study was to investigate how multivitamin use is associated with the risk of CVD in initially healthy men free of CVD at baseline. Methods: We studied 21,981 male physicians aged ≥40y from the Physicians Health Study I cohort who were free of CVD and cancer at baseline starting in 1982. All men provided a wide range of self-reported lifestyle and clinical factors plus intake of selected food and dietary supplements. Men were categorized at baseline as (1) no current use and (2) current use of multivitamins. Men were followed from baseline to the end of PHS I follow-up. Cox proportional hazards models were used to calculate multivariable-adjusted rate ratios (RR) (95% confidence intervals (CI)). Results: During an average of 13.7 y (total of 301,480 person-years) of follow-up, there were 1,269 incident cases of major CVD (defined as nonfatal myocardial infarction (MI), nonfatal stroke, and CVD death). In multivariable analyses, there were no statistically significant RRs (95% CIs) observed when comparing current multivitamin use versus no use for the risk of major CVD events (0.97 (0.79-1.04)), MI (0.94 (0.76-1.16), stroke (0.97 (0.77-1.23), or CVD death (1.02 (0.83-1.14)) but an inverse association was observed for cardiac revascularization (0.87 (0.75-1.00)). Conclusion: In this long-term prospective study among initially healthy men, baseline multivitamin use was not associated with the long-term risk of major CVD events.
The tumour suppressor p53 is frequently nonfunctional in Sézary syndrome
Authors: B. Lamprecht, S. Kreher, M. Möbs, W. Sterry, B. Dörken, M. Janz, C. Assaf, S. Mathas
Journal: British Journal of Dermatology (2012)

Primary cutaneous T-cell lymphomas (CTCLs) are a heterogeneous group with Sézary syndrome (SS) as one of the most aggressive variants. Recently, we identified a loss of E2A as a recurrent event in SS, which enhanced proliferation via upregulation of the proto-oncogene MYC. MYC-induced transformation usually requires deleterious alterations of key apoptotic genes including p53; however, p53 functionality and mutation status in SS are unclear.We investigated functionality of p53 signalling by pharmacological treatment with the MDM2 antagonist nutlin-3, which might result in p53 activation. Furthermore, we analysed the TP53 mutation status in CTCL cell lines and highly purified tumour cells from patients with SS by mRNA and DNA sequencing.We analysed the apoptosis induction due to nutlin-3 treatment in various SS cell lines and primary patient samples by annexin V/propidium iodide staining. Induction of p53 target genes was analysed by immunoblotting, and TP53 was sequenced at the mRNA and DNA level.We identified various TP53 mutations and an impaired p53 signalling in the vast majority of the investigated cell lines and primary SS cells.In accordance with the importance of MYC deregulation in SS, p53 signalling is frequently nonfunctional in SS. However, although most likely ineffective as exclusive treatment in SS, it remains possible that pharmacological p53 activation could be beneficial in combination with other approaches including classical chemotherapeutics.
Noninvasive Respiratory Monitoring.
Authors: Michael L. Nochomovitz, Neil S. Cherniack
Journal: Annals of Internal Medicine (1986)

This book contains 10 selections. Some of the titles are: Transcutaneous Monitoring of Respiratory Gases; Computed Tomography of the Chest; Measurement and Monitoring of Exhaled Carbon Dioxide; Oximetry; and Ultrasonic Evaluation of the Chest Wall and Pleura.
Abstract 1596: CXCL13 as a mediator of oncogenic PKCϵ in prostate cancer
Authors: Rachana Garg, Martin Abba, Marcelo G. Kazanietz
Journal: Cancer Research (2014)

Abstract Protein kinase C epsilon (PKCϵ), a member of the PKC family of phorbol ester/diacylglycerol receptors, has emerged as an oncogenic kinase and plays important role in cell survival, mitogenesis and invasion. PKCϵ is up-regulated in most epithelial cancers, including prostate cancer. We recently showed that transgenic PKCϵ overexpression in the mouse prostate under the control of probasin (PB) promoter leads to hyperplasia and prostatic intraepithelial neoplastic lesions but is insufficient to drive neoplastic changes. Strikingly, when we intercrossed the prostate-specific PKCϵ transgenic mice with mice haploinsufficient for Pten, a common genetic alteration in human prostate cancer, the resulting compound mutant mice (PB-PKCϵ;Pten+/- mice) developed fully invasive adenocarcinoma (unpublished observation). In the present study, to explore the mechanistic aspects of the observed cooperativity between PKCϵ overexpression and Pten deficiency, we stably overexpressed PKCϵ in mouse prostate epithelial lines that are either heterozygous (P8) or homozygous (CaP8) for Pten deletion. PKCϵ overexpression led to significant enhancement in cell proliferation as well as enhanced the levels of phospho-Akt, phospho-Erk and phospho-mTOR; these effects are more pronounced in CaP8 cells. Moreover, migration, invasion, clonogenic and soft agar colony formation assays revealed a striking synergism between PKCϵ overexpression and Pten loss. Furthermore, analysis of global gene expression by microarray revealed significant changes in gene related to EMT, adhesion, metabolism, and invasiveness following PKCϵ overexpression, Pten loss or both. In particular, a chemokine CXCL13 was found to be majorly up-regulated in CaP8-PKCϵ cells. Measurement of CXCL13 mRNA by qPCR or CXCL13 release to the conditioned medium (CM) by ELISA showed increased levels in PKCϵ overexpressing or Pten depleted cells, and these effects were synergistically enhanced in CaP8-PKCϵ cells. Remarkably, CM from CaP8-PKCϵ cells led to significant induction in growth and motility of P8 cells. Importantly, CXCL13 RNAi depletion reduced the proliferative and migratory capacity of CaP8-PKCϵ cells, thereby establishing the potential relevance of CXCL13 in the phenotypic effects of PKCϵ overexpression and Pten loss. Concurrently, the growth and motile activity of P8 cells were enhanced in response to exogenously added CXCL13. Overall, our results argue for the role of CXCL13 in mediating effects of oncogenic PKCϵ in prostate cancer. Citation Format: Rachana Garg, Martin Abba, Marcelo G. Kazanietz. CXCL13 as a mediator of oncogenic PKCϵ in prostate cancer. [abstract]. In: Proceedings of the 105th Annual Meeting of the American Association for Cancer Research; 2014 Apr 5-9; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2014;74(19 Suppl):Abstract nr 1596. doi:10.1158/1538-7445.AM2014-1596
Safety and efficacy of upfront plerixafor + G‐CSF versus placebo + G‐CSF for mobilization of CD34<sup>+</sup> hematopoietic progenitor cells in patients ≥60 and &lt;60 years of age with non‐Hodgkin's lymphoma or multiple myeloma
Authors: Ivana N. Micallef, Patrick J. Stiff, Edward A. Stadtmauer, Brian J. Bolwell, Auayporn P. Nademanee, Richard T. Maziarz, Angela M. Partisano, Sachin Marulkar, John F. DiPersio
Journal: American Journal of Hematology (2013)

The efficacy and safety of plerixafor + G-CSF in enhancing hematopoietic stem cell mobilization and collection has been demonstrated in two phase III studies involving patients with NHL or MM. In these pivotal studies, plerixafor + G-CSF significantly increased the proportion of patients achieving target stem cell yields, compared to placebo + G-CSF. In this analysis, we compare the efficacy and safety of plerixafor + G-CSF versus placebo + G-CSF in patients enrolled in the two phase III studies, stratified by age: ≥60 years of age and <60 years of age. The proportion of older patients who achieved target stem cell yields was significantly higher in the plerixafor group than in placebo group (NHL: 50.9 vs. 25.4%, P < 0.001; MM: 69.6 vs. 23.7%, P < 0.001). In this older cohort, the median times to neutrophil and to platelet engraftment following autologous stem cell transplant were comparable between the plerixafor and placebo groups. Similar efficacy findings were observed in the younger age group. The most common adverse events (all grades) reported among older patients in the plerixafor group included diarrhea (41.3%), nausea (38.9%), fatigue (30.2%), and injection-site reaction (29.4%). The frequency of adverse events was similar between the older and the younger age groups. Taken together, our subanalysis demonstrate that plerixafor + G-CSF can be safely and effectively used in adult patients of all ages, including those ≥60 years, to support optimal stem cell mobilization for autologous stem cell transplantation.
Johann Friedrich Meckel, the Younger (1781-1833)
Authors: Romina A Parquet
Journal: JAMA (1970)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
ABC of Sexually Transmitted Diseases
Authors: Michael W. Adler
Journal: Annals of Internal Medicine (1990)

In 1983?84 Michael Adler wrote a series of short articles on sexually transmitted disease, published by the British Medical Journal in one volume in 1984.The format of the second edition also comprises 18 chapters, but it is longer than the first edition by 13 pages.This is mainly attributable to a more comprehensive chapter on AIDS and to the chapter on psychosexual problems being reorganised and extended.To expect figures on how frequently a disease is occurring in 1989-90 would be unrealistic; thus, these are updated to no later than 1986-87.Many of the illustrations of disease are now in colour, but it is a pity that the line drawing of a two-glass urine test was not retained from the first edition since in the colour photograph the refractions from the glass can be misconstrued, and that the opportunity was not taken to improve the quality of the herpes virus and wart virus electron micrographs.The desirability of testing for Chlamydia trachomatis on men with acute NGU is questionable, particularly in cost-effective terms since treatment for chlamydia-negative and chlamydia-positive disease is the same.Vaginal discharge is an important condition commonly seen in STD clinics, but it would have been appropriate to single out bacterial vaginosis in the sec- tion on management and include it in the management chart on page 16, as has been done for candidia- sis and trichomoniasis.Sooner or later there will have to be standardisation of terminology: 'bacterial vaginosis' and 'anaerobic vaginosis' appear on the same page, these terms and 'vaginal bacteriosis' being synonyms for the outdated 'non-specific vaginitis'.
Selective inhibition of fibroblast activation protein protease based on dipeptide substrate specificity
Authors: Conrad Y. Edosada, Clifford Quan, Christian Wiesmann, Thuy Tran, Dan Sutherlin, Mark Reynolds, J. Michael Elliott, Helga Raab, Wayne Fairbrother, Beni Wolf
Journal: Cancer Research (2006)

Proc Amer Assoc Cancer Res, Volume 47, 2006

4375 

Fibroblast activation protein (FAP) is a transmembrane serine peptidase that belongs to the prolyl peptidase family. FAP has been implicated in cancer; however, its specific role remains elusive because inhibitors that distinguish FAP from other prolyl peptidases like dipeptidyl peptidase-4 (DPP-4) have not been developed. To identify peptide motifs for FAP-selective inhibitor design, we used P2-Pro1- and Acetyl (Ac)-P2-Pro1-dipeptide substrate libraries, where P2 was varied and substrate hydrolysis occurs between Pro1 and a fluorescent leaving group. With the P2-Pro1-library, FAP preferred Ile, Pro, or Arg at the P2 residue, however, DPP-4 showed broad reactivity against this library, precluding selectivity. By contrast, with the Ac-P2-Pro1-library, FAP cleaved only Ac-Gly-Pro while DPP-4 showed little reactivity with all substrates. FAP also cleaved formyl-, benzyloxycarbonyl- and biotinyl-Gly-Pro-substrates, which DPP-4 cleaved poorly, suggesting an N-acyl-Gly-Pro motif for inhibitor design. Therefore we synthesized and tested the compound Ac-Gly-prolineboronic acid (BoroPro), which inhibited FAP with a Ki of 23 ± 3 nM. This was ∼9-5400-fold lower than the Ki values for other prolyl peptidases including DPP-4, DPP-7, DPP-8, DPP-9, prolyl oligopeptidase and acyl peptide hydrolase. These results identify Ac-Gly-BoroPro as a FAP-selective inhibitor and suggest that N-acyl-Gly-Pro-based inhibitors will allow testing FAP as a therapeutic target.
Blockade of BCL-2 proteins efficiently induces apoptosis in progenitor cells of high-risk myelodysplastic syndromes patients
Authors: S Jilg, V Reidel, C Müller-Thomas, J König, J Schauwecker, U Höckendorf, C Huberle, O Gorka, B Schmidt, R Burgkart, J Ruland, H-J Kolb, C Peschel, R A J Oostendorp, K S Götze, P J Jost
Journal: Leukemia (2015)
Abstract 4355: Functional Status Is More Strongly Associated with Mortality in Cardiac Amyloid Compared to Echocardiographic Parameters
Authors: Bethany A Austin, Brendan Duffy, Rene Rodriguez, Carmela Tan, Randall C Starling, Milind Y Desai
Journal: Circulation (2008)

Cardiac amyloidosis (CA) is generally associated with a poor prognosis and significantly increased mortality. We sought to identify predictors of longer-term survival in patients with EMB documented CA. Forty-five consecutive EMB documented CA patients were studied from 1/98 –12/03. Age, gender, NYHA class, medications, presence of light chain amyloid and ECG voltage were recorded. Baseline left ventricular ejection fraction (LVEF), deceleration time (DT), diastology, LV mass, interventricular septal (IVS) thickness and myocardial performance index (MPI) [(isovolumic contraction time + isovolumic relaxation time)/ejection time] were recorded. Length of follow-up and all-cause mortality were recorded. Mean age was 66 ±10 years with 34 (76 %) men. NYHA class &gt; 2 and low voltage on ECG [S (V1) + R (V5) ≤12] were noted in 26 (58 %) and 12 (27 %) patients, respectively. Mean LVEF, IVS thickness and LV mass were 46 % ±13, 1.7 cm ±0.42 and 303 grams ±114, respectively. DT &lt;150 msec and MPI &gt; 0.6 were found in 19 (42 %) and 15 (33 %) patients, respectively. At median follow-up of 1.7 years, there were 25 (56%) deaths. On univariate Kaplan-Meier survival analysis, NYHA class &gt; 2, DT &lt;150 msec and lack of beta-blocker use were associated with increased mortality (log-rank statistic p-values &lt;0.001, &lt;0.05 and 0.01, respectively). Cox Proportional Hazard Survival Analysis is shown in the table . In patients with EMB-documented CA, s urvival is more strongly associated with NYHA functional class compared to ECG and echocardiographic variables, including DT and MPI. Evaluation of advanced imaging techniques such as cardiac magnetic resonance in predicting prognosis in these patients is warranted. Table: Cox Proportional Hazard Analysis of Various Clinical, Electrocardiographic and Echocardiographic Predictors of Mortality in Patients with Biopsy Proven Cardiac Amyloidosis
Transluminal Stent-Graft Placements for the Treatments of Acute Onset and Chronic Aortic Dissections
Authors: Takatsugu Shimono, Noriyuki Kato, Fuyuhiko Yasuda, Tomoaki Suzuki, Uhito Yuasa, Koji Onoda, Tadanori Hirano, Kan Takeda, Iaso Yada
Journal: Circulation (2002)

Transluminal stent-graft placement (TSGP) for aortic dissection is a relatively new procedure. We performed TSGPs to seal the primary entry site to treat and prevent complications of aortic dissection. The early to mid-term outcomes were analyzed.Thirty-seven patients with a primary intimal tear in descending aorta underwent TSPG. TSGP was performed in 16 acute onset dissections (AOD) with dissection-related complications instead of emergency surgery. Eight AOD without complications were treated to prevent aneurysmal enlargement. Thirteen chronic dissections were treated to prevent rupture. TSGP was technically successful in all cases. One patient with prehospital rupture died. The hospital mortality rate was of 2.7% overall, 6.3% in AOD with complications, 0% in AOD without complications and in chronic dissections. One persistent endoleak required open surgery, and 1 intimal tear was caused by the stent-graft, necessitating an additional TSGP. The primary success rate was 94.4% overall. After hospital discharge, no patient died or suffered aortic rupture during an average follow-up of 24.5 months. New intimal tears caused by the stent-grafts and a secondary endoleak developed in 3 AOD patients. One open procedure and 2 additional TSGPs were performed. Actuarial survival rate and cardiovascular event-free rate at 2 years are 97.3% and 78.3% overall, 93.8% and 48.0% in AOD with complications, 100% and 87.5% in AOD without complications, and both 100% in chronic dissections.TSGP is a reasonable treatment option for aortic dissection. However, delayed intimal tear formations caused by the stent-graft is a problem that requires further investigation.
NON-ICTERIC LEPTOSPIROSIS ICTEROHEMORRHAGIA (WEIL'S DISEASE) CONTRACTED WHILE BATHING
Authors: Perk Lee Davis, Margaret Shumway Davis
Journal: Annals of Internal Medicine (1942)

Case Reports1 March 1942NON-ICTERIC LEPTOSPIROSIS ICTEROHEMORRHAGIA (WEIL'S DISEASE) CONTRACTED WHILE BATHINGPERK LEE DAVIS, M.D., F.A.C.P., MARGARET SHUMWAY DAVIS, M.D.PERK LEE DAVIS, M.D., F.A.C.P.Search for more papers by this author, MARGARET SHUMWAY DAVIS, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-16-3-569 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptBecause the term Weil's disease is usually associated with a severe infection with jaundice and bleeding, it is possible that the correct diagnosis of cases without these features is seldom made. According to several opinions jaundice is said to be present in about 50 per cent of cases, but it is probable that if all mild cases were recognized the proportion would be much lower. Jaundice and bleeding are characteristic of the severe infections. Since a clinical diagnosis can not be made in the mild form, it is necessary to apply various biologic tests. It is important, of course, that...Bibliography1. HAVENSBUCHERREIMANN WPCJHA: Leptospirosis: a public health hazard, Jr. Am. Med. Assoc., 1941, cxvi, 289-291. CrossrefGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: *Received for publication March 24, 1941. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 March 1942Volume 16, Issue 3Page: 569-570KeywordsBiologicsHemorrhageInfectious diseasesLeptospirosis ePublished: 1 December 2008 Issue Published: 1 March 1942 PDF downloadLoading ...
Abstract 20058: Comparative Effectiveness of Standard Non-invasive Cardiac Imaging in Stable Outpatients: an Analysis of Downstream Testing, Interventions, and Outcomes
Authors: Andrew Foy, Guodong Liu, William R Davidson, Doug Leslie
Journal: Circulation (2014)

Introduction: We sought to determine the comparative effectiveness of different non-invasive cardiac testing strategies on downstream testing, interventions, and outcomes in stable, privately-insured outpatients.

Methods: Retrospective analysis of health insurance claims data for a national sample of privately insured patients over the years 2009-2011. Individuals who received exercise electrocardiography (ExECG), stress echocardiography (SE), myocardial perfusion scintigraphy (MPS), or coronary computed tomography angiography (CCTA) for the first time as an outpatient during the year 2010 were evaluated for cardiac catheterization, revascularization, repeat non-invasive testing, and hospitalizations for acute myocardial infarction (MI) over 360 days of follow-up. Baseline characteristics were collected in the 360 day period prior to the index test. Patients were excluded if they had an emergency department encounter for chest pain or hospitalization for MI within 3 months prior to the index test.

Results: A total of 528,202 patients at an average of 52 years of age were included in the final cohort. Compared with ExECG, the reference standard, SE was associated with a slightly higher rate of revascularization but lower rate of repeat non-invasive testing (Figure). MPS and CCTA were associated with significantly higher rates of cardiac catheterization, revascularization, and repeat non-invasive testing (Figure). Hospitalizations for MI did not significantly differ across index test groups.

Conclusions: ExECG and SE are associated with significantly lower rates of downstream catheterization, revascularization, and repeat non-invasive testing compared to MPS and CCTA without any difference in the rate of hospitalizations for MI. MPS and CCTA may lead to overdiagnosis and overtreatment of obstructive CAD in this patient population.

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Providing an in-home allergen control intervention*1A comparison of behavioral changes in inner-city homes of children with asthma
Authors: K.A. Callahan, C.S. Rand, M.M. Grant, J.M. Curtin-Brosnan, L.J. Swartz, G.B. Diette, P. Breysse, J.A. Krishnan, S. Kanchanaraksa, P.A. Eggleston
Journal: Journal of Allergy and Clinical Immunology (2004)