tbuckley/cabot-search huggingface dataset:
RESPIRATORY MANIFESTATIONS OF DORSAL SPINE RADICULITIS SIMULATING CARDIAC ASTHMA
Authors: D DAVIS
Journal: Annals of Internal Medicine (1950)

Article1 May 1950RESPIRATORY MANIFESTATIONS OF DORSAL SPINE RADICULITIS SIMULATING CARDIAC ASTHMADAVID DAVIS, M.D.DAVID DAVIS, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-32-5-954 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptIn a previous study attention was called to the syndrome of dorsal spine radiculitis with attacks of substernal and precordial pain simulating coronary occlusion.1It was shown that such attacks were frequently accompanied by a peculiar respiratory distress described most often as an inability to take a deep breath. This discomfort was noted not only during severe paroxysms of pain, but at times after chest pain had abated or ceased. In several instances, it could be induced together with chest pain by the application of pressure over the dorsal vertebrae, and a few patients found it more distressing than the...Bibliography1. Davis D: Spinal nerve root pain (radiculitis) simulating coronary occlusion: a common syndrome, Am. Heart J. 35: 70-80, 1948. CrossrefMedlineGoogle Scholar2. DavisRitvo DM: The clinical and roentgen findings in osteoarthritis of the cervicodorsal spine (radiculitis) simulating coronary artery disease, New England J. Med. 238: 857-866, 1948. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Boston, Massachusetts*Received for publication August 3, 1948. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byTrue Angina Pectoris Immediately After Cervical Disc Herniation Surgery for Preoperative Cervical Angina Symptoms: A Case ReportCervical Angina: A Literature Review on Its Diagnosis, Mechanism, and ManagementDifferent Surgical Strategy for Patients with Cervical Angina: A Potential Role of Luschka's Joint OsteophyteCervical Angina of High Cervical Disc HerniaCervical Angina caused by Unstable Cervical Spondylotic Myelopathy: A Case ReportCervical Angina Caused by Atlantoaxial InstabilityAtypische Angina pectorisDifferential diagnosis of chest painA COMMON TYPE OF VERTIGO RELIEVED BY TRACTION OF THE CERVICAL SPINE*DAVID DAVIS, M.D. 1 May 1950Volume 32, Issue 5Page: 954-959KeywordsAsthmaIschemiaSpineVertebrae ePublished: 1 December 2008 Issue Published: 1 May 1950 PDF downloadLoading ...
Newer Aspects in Paradentosis (Pyorrhea)
Authors: Hermann Becks
Journal: Annals of Internal Medicine (1932)

Article1 July 1932Newer Aspects in Paradentosis (Pyorrhea)HERMANN BECKS, M.D., D.D.S.HERMANN BECKS, M.D., D.D.S.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-6-1-65 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptOur conceptions of the true anatomic conditions in the region of the tooth supporting tissues or "paradentium" (Weski) have recently undergone a definite change through the work of contemporary histologists and clinicians (Boenheim, Citron, Gottlieb, Häupl, Lang, Loos, Weinmann, Weski).This change in our ideas brought about a renewed interest in the etiologic and pathogenetic questions in paradentosis in all countries. Today after twelve years have elapsed there are still questions of fundamental importance which are under debate, the solution of which may not be reached in any short space of time. These are mainly histologic details which, however, are... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: San Francisco, California*Presented at the San Francisco Meeting of the American College of Physicians, April 5, 1932. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byComparative roentgenographic and histologic study of human mandiblesPathogenic Importance of the Endocrine Glands in Parodontal DiseaseRelationship between Endocrine Dysfunction and Paradental Disease**Read before the Periodontic Section at the Sixty-Second Annual Convention of the California State Dental Association, Oakland, April 5, 1932. 1 July 1932Volume 6, Issue 1Page: 65-71KeywordsPathogens ePublished: 1 December 2008 Issue Published: 1 July 1932 PDF downloadLoading ...
Abstract 15660: Insulated Radiofrequency Ablation Catheter
Authors: Janice V Huang, William Sauer, Lijun Zheng, Waseem Barham, Duy T Nguyen
Journal: Circulation (2014)

Background:  Radiofrequency RF ablation utilizes low-voltage to deliver high frequency electrical energy to myocardial tissue to create permanent lesions. RF delivery systems are rudimentary in design and deliver energy at 360 degrees from the tip surface allowing for dissipation of energy. We propose a design modification to current radiofrequency ablation catheters by insulating a portion of the ablation catheter tip, which improves efficiency of RF delivery and requires less RF power.   Hypothesis:  An insulated portion of the ablation catheter will concentrate the flow of energy toward the non-insulated side, increasing temperature and lesion size compared with a standard catheter.   Methods:  Three catheter tips were insulated using silicone based material to cover half their surfaces. These included a 4mm, 8mm, and an open-irrigated tip catheter. The insulated catheter was compared to its standard counterpart. Energy was delivered to myocardial tissue submerged in a saline bath heated to 37°C at 20 watts (W) for 60 seconds. Measurements of lesion depth and temperatures at 3mm and 5mm depth were compared between the catheter types.   Results:  At 20W, lesion depths were significantly larger for the insulated 4mm, 8 mm, and irrigated tip catheters, compared to their counterpart (Table). Peak temperatures at 3 and 5 mm depths were significantly higher for the insulated 4mm, 8 mm, and irrigated tip catheters, compared to their counterpart (Table).   Conclusion:  By insulating the tip of an RF ablation, efficiency of RF delivery is increased, with larger lesion sizes and higher temperatures. Lower powers can be used with insulated catheters to create lesion depths similar to those seen with standard catheters at higher power.
Stool-Sniffing Science
Authors: Joan Stephenson
Journal: JAMA (2004)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
798. Intracarotid Delivery of Oncolytic Herpes Simplex Virus-1 G47Δ to Metastatic Breast Cancer in the Brain
Authors: Renbin Liu, Robert L. Martuza, Samuel D. Rabkin
Journal: Molecular Therapy (2004)

Breast cancer is the most frequently occurring malignant disease in women with a lifetime risk of 1:8 to 1:10 in the United States. Approximately 20% of breast cancer patients have brain metastases, which are the most important cause of the morbidity and mortality. The blood brain barrier (BBB) separates the brain's interstitial space from the blood and prevents the penetrance of circulating molecules and cells into the brain. This is a significant impediment to systemic delivery in the brain.
Interobserver Agreement About Cervical Cytologic and Histologic Diagnosis—Reply
Authors: Mark H. Stoler
Journal: JAMA (2001)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The membrane-cytoskeleton linker ezrin provides a survival advantage to metastatic osteosarcoma cells that reach in the lung
Authors: Sung-Hyeok Hong, Arnulfo Mendoza, Ling Ren, Chand Khanna
Journal: Cancer Research (2005)

Proc Amer Assoc Cancer Res, Volume 46, 2005

5678 

Despite successful control of the primary tumor and adjuvant chemotherapy, death from osteosarcoma (OSA) pulmonary metastases occurs in over 30% of patients within 5 years. Using a genomic approach we identified ezrin, a membrane-actin cytoskeleton linker protein, to be over-expressed and necessary for metastasis in the highly aggressive K7M2 murine OSA model. Studies in child-hood OSA patients suggested that high expression of ezrin was associated with a shortened disease free interval. By imaging single metastatic cells early in the process of experimental metastasis in mice, we demonstrated that ezrin expression was important as early as 6 hours after metastatic cells arrive in the lung. The suppression of ezrin in metastatic cells resulted in a marked reduction in the number of cells imaged within the lung compared to cells with high levels of ezrin. To determine if the early metastatic advantage provided by ezrin was the result of enhanced survival of cancer cells in the lung, we delivered fluorescent-labeled green (CMFDA) K7M2 OSA cells with high ezrin (K7M2-wild type (wt), pCIneo (neo) empty vector) and cells with suppressed ezrin (K7M2AS1.46 and K7M2AS 1.52) to mice by tail vein injection. Lungs were formalin fixed 1, 3, and 6 hours after tumor cell injection and then evaluated for apoptotic events using red fluorescent TUNEL immunohistochemical staining. Two-color analysis (green tumor cell: red apoptotic cell) of lung sections suggested that ezrin expression suppressed apoptosis in tumor cells early after arrival in the lung. The apoptotic rate for tumor cells within the lung 3 hours after experimental metastasis was low in cells with high ezrin (4.6 %, 12/263 (K7M2-wt; apoptotic cells/tumor cells) and 14.6 %, 18/123 (K7M2-neo)); whereas, in cells with suppressed ezrin the apoptotic rate was significantly higher (40.2 %, 39/97 (K7M2-AS1.46) and 31.3 %, 5/16 (K7M2-AS 1.52)) (p<0.001, Fischer’s exact t-test). Similar ezrin-associated differences in apoptotic rate were seen 6 hours after experimental metastasis; however, the detection of very small numbers of low ezrin expressing cells precluded detailed analysis. The localization of apoptotic and surviving cancer cells within the lung is currently being studied in these tissues by confocal microscopy. These data suggest that ezrin in part contributes to metastatic potential of cancer cells by enhancing their survival early after arrival in the lung. Ongoing efforts are underway to examine if previously defined ezrin dependent pathways are contributing to this early survival advantage.
Genome-wide methylation profile of nasal polyps: relation to aspirin hypersensitivity in asthmatics
Authors: H. S. Cheong, S.-M. Park, M.-O. Kim, J.-S. Park, J. Y. Lee, J. Y. Byun, B. L. Park, H. D. Shin, C.-S. Park
Journal: Allergy (2010)

To cite this article: Cheong HS, Park S-M, Kim M-O, Park J-S, Lee JY, Byun JY, Park BL, Shin HD, Park C-S. Genome-wide methylation profile of nasal polyps: relation to aspirin hypersensitivity in asthmatics. Allergy 2011; 66: 637–644. Abstract Background: In addition to the dysregulation of arachidonic acid metabolism in aspirin-intolerant asthma (AIA), aspirin acetylsalicylic acid (ASA) exerts effects on inflammation and immunity; however, many of these effects are unknown. Objective: The aim of the study was to evaluate the methylation status of whole genome in blood and polyp tissues with and without aspirin hypersensitivity. Methods: Genome-wide DNA methylation levels in nasal polyps and peripheral blood cells were examined by microarray analysis using five subjects with AIA and four subjects with aspirin-tolerant asthma (ATA). Results: In the nasal polyps of the patients with AIA, hypermethylation was detected at 332 loci in 296 genes, while hypomethylation was detected at 158 loci in 141 genes. Gene ontologic and pathway enrichment analyses revealed that genes involved in lymphocyte proliferation, cell proliferation, leukocyte activation, cytokine biosynthesis, cytokine secretion, immune responses, inflammation, and immunoglobulin binding were hypomethylated, while genes involved in ectoderm development, hemostasis, wound healing, calcium ion binding, and oxidoreductase activity were hypermethylated. In the arachidonate pathway, PGDS, ALOX5AP, and LTB4R were hypomethylated, whereas PTGES was hypermethylated. Conclusion: The nasal polyps of patients with AIA have characteristic methylation patterns affecting 337 genes. The genes and pathways identified in this study may be associated with the presence of aspirin hypersensitivity in asthmatics and are therefore attractive targets for future research.
Abstract P026: Gender Difference of the Association of Serum Polyunsaturated Fatty Acids With the Evolution of Hemodynamics
Authors: Chisa Matsumoto, Hirofumi Tomiyaa, Akira Yamashina
Journal: Circulation (2015)

Background: While abnormal hemodynamics and abnormal lipid profiles of polyunsaturated fatty acids (PUFAs) are noted as risk for cardiovascular disease, their association has not been fully clarified. Objective: We examined whether plasma PUFAs (Arachidonic acid (AA), Eicosapentaenoic acid (EPA), and Docosahexaenoic acid (DHA)) levels are associated with change of hemodynamics in healthy middle aged Japanese subjects. Design: 1,527 healthy Japanese subjects (316 women) were prospectively followed up for three years from 2008. Central blood pressure (CBP), brachial pulse wave velocity (baPWV), and radical augmentation index (rAI) were measured as marker of hemodynamics. CBP and rAI were measured by arterial applanation tonometry, and baPWV was measured using volume plethysmographic apparatus. Multivariate linear regression adjusted for established risk factors for raised blood pressure were performed to evaluate the association between each PUFAs and change of hemodynamics (CSBP, ba PWV, raAI) during 3year...
Abstract 17138: Intravenous Regadenoson with Aminophylline Reversal is Safe and Equivalent to Intracoronary Adenosine Infusion for Fractional Flow Reserve Measurements
Authors: John Lee, Sepehir Saberian, Christopher White, Tyrone Collins, John P Reilly, Steven Ramee, J S Jenkins, Louis Salvaggio, Dan Morin, Rajan Patel, Alexandre Benjo, Robert Bober
Journal: Circulation (2014)

Background: Small studies have shown that Adenosine is equivalent to Regadenoson when obtaining Fractional Flow Reserve (FFR) measurements. A larger study that also evaluates time and safety of aminophylline reversal was yet to be presented. Methods: After IRB approved consent was obtained, 46 consecutive patients with clinically indicated FFRs were enrolled between 4/2012 and 5/2014. Each patient had FFR measured with adenosine 140 mcg/kg/min IV then allowed to return to baseline. FFR was repeated with Regadenoson 140 mcg IV bolus than reversed with aminophylline 150 mg IV and time to baseline hemodynamics were measured. Tests were compared using linear regression. Reversal time recorded in seconds. Results: As demonstrated in Figure1 FFR results were similar with both agents, R2 = 0.935, p&lt;0.0001. Also, using the 0.80 cutoff, there was no divergence regarding studies significance. After aminophylline, hemodynamics returned to baseline in 112+/- 72 secs. There were no side-effects reported. Conclusion: The use of regadenoson for FFR measurements provides results consistent with the ones obtained with adenosine infusion. Aminophilline reversal for regadenoson was fast, well tolerated and safe. Regadenoson with aminophylline reversal may be considered as an alternative for FFR measurements.
Primary results of the Rapid Emergency Department Heart Failure Outpatient Trial (REDHOT)
Authors: Alan Maisel, Judd E. Hollander, David Guss, Peter McCullough, Richard Nowak, Gary Green, Mitchell Saltzberg, Stefanie R. Ellison, Meenakshi Awasthi Bhalla, Vikas Bhalla, Paul Clopton, Robert Jesse
Journal: Journal of the American College of Cardiology (2004)
Risk Factors for Malignant Ventricular Arrhythmias in Lamin A/C Mutation Carriers
Authors: Ingrid A.W. van Rijsingen, Eloisa Arbustini, Perry M. Elliott, Jens Mogensen, Johanna F. Hermans-van Ast, Anneke J. van der Kooi, J. Peter van Tintelen, Maarten P. van den Berg, Andrea Pilotto, Michele Pasotti, Sharon Jenkins, Camilla Rowland, Uzma Aslam, Arthur A.M. Wilde, Andreas Perrot, Sabine Pankuweit, Aeilko H. Zwinderman, Philippe Charron, Yigal M. Pinto
Journal: Journal of the American College of Cardiology (2012)
Abstract 13544: Myocardial Perfusion Reserve by Cardiac Magnetic Resonance Imaging is Related to Angina Stability in Women with Signs and Symptoms of Ischemia and No Obstructive Coronary Artery Disease: Results from the NHLBI-Sponsored Women's Ischemia Syndrome Evaluation Coronary Vascular Dysfunction (WISE-CVD) Study
Authors: Megha Agarwal, Puja Mehta, Tara Sedlak, Chrisandra Shufelt, B. Delia Johnson, Tanya S Kenkre, Margo Minissian, Leslee J Shaw, John W Petersen, Bruce Samuels, Babak Azarbal, R. David Anderson, Saibal Kar, Eileen M Handberg, Behzad Sharif, Debiao Li, Sheryl F Kelsey, Daniel S Berman, Louise E Thomson, Carl J Pepine, C. Noel Bairey-Merz
Journal: Circulation (2012)

Background: Cardiac magnetic resonance imaging (CMRI) is an emerging technique for evaluation of subjects with signs and symptoms of ischemia without obstructive coronary artery disease (CAD). CMRI...
Disparities in the Use of Breast-Conserving Therapy Among Patients With Early-Stage Breast Cancer
Authors: Meeghan Lautner, Heather Lin, Yu Shen, Catherine Parker, Henry Kuerer, Simona Shaitelman, Gildy Babiera, Isabelle Bedrosian
Journal: JAMA Surgery (2015)

Although breast-conserving therapy (BCT) is an accepted modality for treatment of early-stage breast cancer, many women continue to undergo mastectomy. Detailing the factors associated with choice of BCT may assist with overcoming barriers in the use of this treatment modality.To conduct a population-based examination of the factors that influence the use of BCT.Using the National Cancer Data Base, we examined the surgical choices of women with stage T1 or T2 breast cancer treated between 1998 and 2011. Logistic regression analysis conducted between September 19, 2013, and August 26, 2014, was used to assess the multivariate association between patient and facility variables and the probability of undergoing BCT.Factors associated with the use of BCT.A cohort of 727,927 women was identified in the National Cancer Data Base. Use of BCT, determined using odds ratio (OR) and 95% CI, was greater in patients aged 52 to 61 years compared with younger patients (1.14; 1.12-1.15) and in those with the highest educational level (1.16; 1.14-1.19). Rates of BCT were lower in patients without insurance compared with those with private insurance (0.75; 0.72-0.78) and in those with the lowest median income (0.92; 0.90-0.94). Academic cancer programs, US Northeast location, and residence within 27.8 km of a treatment facility were associated with greater BCT rates than were community cancer programs (1.13; 1.11-1.15), Southern location (1.50; 1.48-1.52), and residence farther from a treatment facility (1.25; 1.23-1.27). When comparing BCT use in 1998 with use in 2011, increases were seen across age groups (from 48.2% to 59.7%), in community cancer programs (48.4% in 1998 vs 58.8% in 2011), and in facilities located in the South (45.1% in 1998 vs 55.3% in 2011).Although the use of BCT has increased during the past 14 years, nonclinical factors, including socioeconomic demographics, insurance, and travel distance to the treatment facility, persist as key barriers to receipt of BCT. Interventions that address these barriers may facilitate further uptake of BCT.
Protein Kinase C alpha promotes tumor growth by initiating a feed-forward network involving miR15a and Cyclin E deregulation
Authors: Ezra Cohen, Hongyan Zhu, Leslie Martin, Mark Lingen, Joel Parker, Christine Chung, Marsha Rosner
Journal: Cancer Research (2008)

3586  Protein Kinase C alpha (PKCα) has been implicated in cancer but the mechanism is unknown. Here we show that PKCα inhibitors decrease proliferation in squamous cell carcinoma (SCC) cell lines and inhibit growth of xenografted SCC tumors. PKCα enhances cyclin E protein expression and cyclinE/cdk2 complex formation required for DNA synthesis through inhibition of the microRNA, miR15a. Tissue analysis reveals positive and negative correlations between PKCα and cyclin E or miR15a, respectively; PKCα is also associated with head and neck cancer progression and poor prognosis. These results identify PKCα as a key regulator of tumor growth via activation of a feed-forward network leading to enhanced protein translation followed by increased transcription of E2F target genes that sustain the proliferative signal.