Sugar Absorption Tests, with Special Reference to 3-0-Methyl-d-Glucose and d-Xylose
Authors: JOHN S. FORDTRAN
Journal: Annals of Internal Medicine (1962)

Article1 December 1962Sugar Absorption Tests, with Special Reference to 3-0-Methyl-d-Glucose and d-XyloseJOHN S. FORDTRAN, M.D., PETER H. CLODI, M.D., KONRAD H. SOERGEL, M.D., FRANZ J. INGELFINGER, M.D., F.A.C.PJOHN S. FORDTRAN, M.D., PETER H. CLODI, M.D., KONRAD H. SOERGEL, M.D., FRANZ J. INGELFINGER, M.D., F.A.C.PAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-57-6-883 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTests employing glucose have limited value in the diagnosis of malabsorption because factors other than absorption influence glucose blood levels following an oral dose of this sugar (1). The d-xylose absorption test, introduced by Helmer and Fouts (2), is less influenced by metabolic processes than is the glucose tolerance test, and it has been employed successfully by many workers (3-5). Although the d-xylose test has been useful in the diagnosis of sprue, results are variable with some other diseases (5, 6) and in elderly persons without intestinal disease (7). Furthermore, it has been shown recently that endocrine disorders may influence...References1. RAJANRAOPONNUSAMYBAKER KTPSISJ: The oral glucose-tolerance test in tropical malabsorption syndrome. Brit. Med. J. 1: 29, 1961. CrossrefMedlineGoogle Scholar2. HELMERFOUTS OMPJ: Gastro-intestinal studies. VII. Excretion of xylose in pernicious anemia. J. Clin. Invest. 16: 343, 1937. CrossrefMedlineGoogle Scholar3. FOURMAN LP: The absorption of xylose in steatorrhea. Clin. Sci. 6: 289, 1948. MedlineGoogle Scholar4. BENSONCULVERRAGLANDJONESDRUMMEYBOUGAS JAPJSCMGDE: The d-xylose absorption test in malabsorption syndromes. New Engl. J. Med., 256: 335, 1957. CrossrefMedlineGoogle Scholar5. CHRISTIANSENKURSNERABLAZA PAJBJ: D-xylose and its use in the diagnosis of malabsorptive states. Amer. J. Med. 27: 443, 1959. 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HYDEN S: A turbidometric method for the determination of higher polyethylene glycols in biologic materials. Ann. Roy. Agric. Coll. Sweden 22: 139, 1955. Google Scholar19. WYNGAARDENSEGALFOLEY JBSJB: Physiological disposition and metabolic fate of infused pentoses in man. J. Clin. Invest. 36: 1395, 1957. CrossrefMedlineGoogle Scholar20. FOLINBERGLUND OH: A colorimetric method for the determination of sugars in normal human urine. J. Biol. Chem. 51: 209, 1922. CrossrefGoogle Scholar21. HAMILTON RH: Studies on the Folin method of analysis for glucose in normal urine. J. Biol. Chem. 78: 63, 1928. CrossrefGoogle Scholar22. CRANE RK: Intestinal absorption of sugars. Physiol. Rev. 40: 789, 1960. CrossrefMedlineGoogle Scholar23. CSAKY TZ: Active intestinal transport of 3-0-methylglucose, in Proceedings of the Fourth International Congress of Biochemistry, ed. by Nickerson, W. J., Vienna, 1958, pp. 6-79. Google Scholar24. REYNELLSPRAY PCGH: The absorption of glucose by the intact rat. J. Physiol. (Lond.) 134: 531, 1956. CrossrefGoogle Scholar25. HUNTPATHAK JNJD: The osmotic effects of some simple molecules and ions on gastric emptying. J. Physiol. (Lond.) 154: 254, 1960. CrossrefGoogle Scholar26. HUNT JN: The osmotic control of gastric emptying. Gastroenterology 41: 49, 1961. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Boston, MassachusettsFrom the Evans Memorial and Massachusetts Memorial Hospitals and the Departments of Medicine, Boston University School of Medicine.Parts of this work were published as an abstract in Clin. Res. 9: 237, 1961.Dr. Clodi is an International Lederle Fellow.This investigation was supported by research grant A-3560 (C1) and by traineeship A-5025 (C5) from the Institute of Arthritis and Metabolic Diseases, National Institutes of Health.Requests for reprints should be addressed to John S. Fordtran, M.D., Southwestern Medical School, Department of Internal Medicine, Dallas, Texas. 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