tbuckley/cabot-search huggingface dataset:
Abstract 1752: Age-Related Differences in Left Ventricular Structure and Function: The Multi-Ethnic Study of Atherosclerosis
Authors: Susan Cheng, Veronica R Fernandes, David A Bluemke, Joao A Lima
Journal: Circulation (2007)

Background: Age-related alterations in LV structure and function that may predispose to myocardial dysfunction are not completely understood. We examined the association between older age and indices of LV remodeling in asymptomatic participants of the Multi-Ethnic Study of Atherosclerosis. Methods: We used cardiac MRI to measure LV indices in 5004 participants free of CV disease (ages 45–84) and representing 4 racial/ethnic groups (non-Hispanic white, black, Hispanic, and Chinese); 1099 participants received additional strain analyses. We used linear regression to assess the association between age and LV indices while adjusting for multiple variables, including traditional CV risk factors. Results: Absolute LV mass decreased with age, but this effect was attenuated when mass was indexed to body size ( Table ). However, age was associated with markedly increased mass-to-volume (M/V) ratio (50 mg/mL per decade, p&lt;0.001); this was driven by a substantial reduction in LV end-diastolic volume with older age, a trend that remained significant after indexing volume to body size and adjusting for CV risk factors. Older age was also independently associated with increased ejection fraction but decreased stroke volume and, importantly, with reduced peak systolic strain and strain rate as well as decreased diastolic strain rate. Conclusion: Older age is associated with increased M/V ratio, driven not by increased LV mass but by decreased LV volumes. This age-related remodeling is independently associated with asymptomatic systolic and diastolic myocardial dysfunction and progressively reduced stroke volume in the face of maintained chamber systolic performance indexed by ejection fraction. These data indicate that aging itself confers alterations in LV structure and function that predispose to reduced cardiac output and limited circulatory reserve in the presence of preserved ejection fraction. Relation Between Age and Alterations in LV Structure and Function
Carers' characteristics could be risk factors
Authors: O. Zanetti, G. B Frisoni, A. Bianchetti, G. Tamanza, V. Cigoli, M. Trabucchi
Journal: BMJ (1996)

Depression in carers of elderly people living at home Alcohol misuse could be a factor EDIToR,-In their study of the prevalence of depression in carers of elderly people living at home, Gill Livingston and colleagues used diagnoses according to ICD-10.1However, there was no mention of the ICD-10 category F1O-F19, disorders due to psychoactive substance use.I suppose this was due to it not being sought rather than it not existing, as excessive drinking is widespread-28% of men and 11% of women in the general population drink more than the recommended "safe" levels.2My clinical experi- ence suggests that this population of carers may be at increased risk.About 15% of men and 5% of women over the age of 65 drink more than the recommended weekly safe drinking levels.In community based
Abstract 3428: Presence Of Renal Simple Cysts Is Associated With Increased Risk For Abdominal Aortic Aneurysm
Authors: Bong Gun Song, Shin Yi Jang, Yong Hwan Park, Sang Yeub Lee, Yeon Hyeon Choe, Young Soo Do, Dong Ik Kim, Young Wook Kim, Jidong Sung, Duk-Kyung Kim
Journal: Circulation (2007)

Background : An increased prevalence of abdominal aortic aneurysm (AAA) has been demonstrated in patients with emphysema or inguinal hernia. Therefore, it has been suggested that the cause of AAA is a degenerative disorder of the connective tissue that can not always be explained by means of atherosclerosis. We hypothesized that the presence of renal simple cysts, another possible manifestation of connective tissue weakness, is associated with the increased risk for AAA. We compared incidence of renal simple cyst between the group of patients with AAA and healthy control group. Methods : We reviewed 279 patients with AAA and 1397 healthy control group who underwent abdominal computed tomography as a routine health screening from 1994 to 2006 in Samsung Medical Center. AAA was defined as an aortic diameter equal to or greater than 40 mm. Comparisons between groups were made for established risk factors for AAA. Results : AAA group has significantly more diabetes, smoking, history of anti-hyperlipidemic medication, hypertension, metabolic syndrome, higher systolic blood pressure than control group (all p values &lt;0.0001). In the univariate analysis, prevalence of renal cysts ( p&lt; 0.0001), bilateral renal involvement of cysts ( p&lt; 0.0001), number of renal cysts ( p&lt; 0.0001), and sum of sizes of renal cysts ( p&lt; 0.0001) were significantly higher in AAA group as compared with control group. In the multivariate analysis, a person with renal cyst was more likely (OR: 4.379, CI: 3.402–5.636) to have AAA after adjustment for age, gender, smoking, hypertension, diabetes, HDL and LDL cholesterol. This relationship was similar for bilateral renal involvement of cysts, number of renal cysts, and sum of sizes of renal cysts. Neither a diameter nor an expansion rate of AAA was associated with the size of renal cysts. Conclusion: Patients with AAA have increased burden of renal simple cysts compared to healthy control group. The structural weakness predisposing for renal simple cysts may be associated with the initiation of AAA formation. Prospective study is needed to determine whether the presence of renal cysts can be considered as a risk factor of AAA.
Incontinentia Pigmenti
Authors: A. W. Franklin
Journal: BMJ (1952)

Thank you for your interest in spreading the word about The BMJ.NOTE: We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail. We do not capture any email address. Username * Your Email * Send To * You are going to email the following Incontinentia Pigmenti Your Personal Message CAPTCHA This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
Isolated Systolic Hypertension in Young and Middle-Aged Adults and 31-Year Risk for Cardiovascular Mortality
Authors: Yuichiro Yano, Jeremiah Stamler, Daniel B. Garside, Martha L. Daviglus, Stanley S. Franklin, Mercedes R. Carnethon, Kiang Liu, Philip Greenland, Donald M. Lloyd-Jones
Journal: Journal of the American College of Cardiology (2015)
Abstract 4951: Serum N-Terminal Pro-Brain Natriuretic Peptide Reflects the Grade of Congestive Heart Failure in Children
Authors: Masaya Sugimoto, Hiroki Kajino, Hiromi Manabe, Kazutomo Goh, Kenji Fujieda
Journal: Circulation (2008)

Background: The N-terminal pro-brain natriuretic peptide (NTproBNP) has a longer serum half-life than the brain natriuretic peptide (BNP), and it is reported to be advantageous in the accurate detection of congestive heart failure (CHF) in adults. However, it has not been sufficiently examined in children. Therefore, we investigated which of the 2 peptides is more beneficial and identified their cut-off levels at the CHF grades in children. Methods: Plasma BNP and serum NTproBNP levels were determined in 252 healthy children (median age, 3.5 years) and in 142 children with congenital heart disease (median age, 2.6 years). CHF severity was assessed by using the modified Ross score to classify the severity into 4 grades (I–IV). The BNP and NTproBNP levels were analyzed and compared with the CHF grade. Results: Both BNP and NTproBNP levels increased significantly with the CHF grades (Fig. 1 ). The change in the NTproBNP level was more remarkable in each CHF grade than in BNP. Furthermore, at CHF grades of II or higher, the area under the receiver operating characteristic curve was larger with NTproBNP than with BNP (Fig. 2 ). The cut-off levels of BNP and NTproBNP were 47.3 and 333.4 pg/mL, respectively, in CHF grade II and higher; 101.4 and 2415.5 pg/mL, respectively, in CHF grade III and higher; and 320.0 and 3617.0 pg/mL, respectively, in CHF grade IV. Conclusions: Our study clearly demonstrated that blood levels of BNP and NTproBNP reflected the severity of CHF in the children. Of these, NTproBNP showed better specificity and sensitivity for the evaluation of CHF severity in children. Therefore, we concluded that NTproBNP is beneficial as a biomarker for assessing CHF in children. This research has received full or partial funding support from the American Heart Association, AHA National Center. Fig. 1 Fig. 2
Association analyses identify 38 susceptibility loci for inflammatory bowel disease and highlight shared genetic risk across populations
Authors: Jimmy Z Liu, Suzanne van Sommeren, Hailiang Huang, Siew C Ng, Rudi Alberts, Atsushi Takahashi, Stephan Ripke, James C Lee, Luke Jostins, Tejas Shah, Shifteh Abedian, Jae Hee Cheon, Judy Cho, Naser E Daryani, Lude Franke, Yuta Fuyuno, Ailsa Hart, Ramesh C Juyal, Garima Juyal, Won Ho Kim, Andrew P Morris, Hossein Poustchi, William G Newman, Vandana Midha, Timothy R Orchard, Homayon Vahedi, Ajit Sood, Joseph J Y Sung, Reza Malekzadeh, Harm-Jan Westra, Keiko Yamazaki, Suk-Kyun Yang, Jeffrey C Barrett, Andre Franke, Behrooz Z Alizadeh, Miles Parkes, Thelma B K, Mark J Daly, Michiaki Kubo, Carl A Anderson, Rinse K Weersma
Journal: Nature Genetics (2015)
Simplified MIPI Is a Valid Prognostic Index In The Rituximab Era: Multicenter MCL Study In Japan
Authors: Dai Chihara, Naoko Asano, Tomohiro Kinoshita, Yoshinobu Maeda, Kosei Matsue, Ken Ohmachi, Masataka Okamoto, Ishikazu Mizuno, Toshiki Uchida, Hirokazu Nagai, Michinori Ogura, Ritsuro Suzuki
Journal: Blood (2013)
Focus: Brussels The union gets interested in ethics
Authors: R. Watson
Journal: BMJ (1997)

Scientific advances and the complexity of modern legislation are forcing the European Union to enter the unfamiliar territory of ethics.

Two unrelated developments are largely behind the change in attitude. The first is the progress made in animal cloning–in particular, the arrival of the world's most famous sheep, Dolly, at the Roslin Institute in Scotland earlier this year. The second is the attempt to establish pan-European legislation to ensure patent protection for biotechnological inventions.

Animal cloning, with its implications for humans, has convinced many union leaders of the need to establish clear rules that would …
Undiagnosed HIV infection in patients with viral hepatitis
Authors: Anna Maria Geretti, Sara Madge, Marcus Posner, Geoff Dusheiko, Michael Jacobs
Journal: BMJ (2008)

A third of HIV infected people in the UK are unaware of their infection.1 Many repeatedly access medical care but are not diagnosed until much later in their disease course.1 2 The chief medical officer recently called on doctors to improve recognition of undiagnosed HIV infection nationwide. One strategy is the adoption of routine opt-out HIV testing in settings where undiagnosed people may present.3 While patients’ acceptance may not be an important barrier,4 uncertainties …
Abstract 5130: Leptin Increases Perihematomal Inflammation in Experimental Hemorrhagic Stroke
Authors: Chi K Kim, Wi-Sun Ryu, Beom J Kim, Seung-Hoon Lee, Byung-Woo Yoon
Journal: Circulation (2009)

Background : Leptin, one of the most alleged adipokines, exerts its tissue-protective effect in ischemic injuries by reducing apoptosis through extracellular signal-regulated kinase pathway. In this context, it may be speculated that leptin also confer beneficial effect on hemorrhagic events. However, few studies have elaborated on the association between exogenous leptin and tissue damage in experimental hemorrhagic stroke model. Methods : After inducing intracerebral hemorrhage in mouse brain via the sterotaxic infusion of collagenase, 4mg/kg or 8mg/kg of recombinant leptin or vehicle (phosphate buffered saline) was administered intraperitoneally. Brain water content, reflecting peri-hematomal edema, and hemorrhage volume were measured at 72 hours after inducing hemorrhage. Inflammatory cells expressing myeloperoxidase (MPO) or OX6 were counted at 48 hours, and western blotting for Akt, pAkt, STAT3, pSTAT3, ERK and pERK was performed at 24 hours. Results : Compared to the vehicle injected mice, exogenous leptin increased brain water contents (80.07±0.29% in vehicle group, 80.74±0.32% in 4mg/kg leptin, and 81.48±0.18% in 8mg/kg leptin; rho=0.525 and p&lt;0.01). Based on this result, all the following experiments were performed with 8mg/kg of leptin. Leptin injection also augmented infiltration of MPO-stained cells (210±8 cells/mm 3 in leptin group and 133±8 cells/mm 3 in vehicle group; p&lt;0.05) and OX6-stained cells (129±13 cells/mm 3 in leptin group and 88±10 cell/mm 3 in vehicle group; p&lt;0.05). Mean hemorrhage volume was also increased in 8mg/kg leptin group (26.83±3.22 mm 3 in leptin group and 17.98±2.73 mm 3 in vehicle group; p&lt;0.05). The expression level of phosphorylated STAT3 was significantly elevated in mice with 8mg/kg leptin injection (p&lt;0.05), however, pAkt and pERK did not augmented by induced hyperleptinemia. Conclusion : Our study documented that peri-hematomal inflammation and hemorrhage volume were increased by exogenous leptin via STAT3 pathway. These results may indicate the potentially detrimental role of leptin on hemorrhagic stroke via augmentation of inflammatory response after tissue damage.
Abstract 15162: Plasma Levels of Circulating MicroRNAs Correlate with Coronary Plaque Burden as Assessed by Cardiac Computed Tomography
Authors: Johannes Rixe, Andreas Rolf, Stephan Fichtlscherer, Helge Moellmann, Holger M. Nef, Christoph Liebetrau, Sebastian Szardien, Andreas M. Zeiher, Stephan Achenbach, Christian W. Hamm, Stefanie Dimmeler
Journal: Circulation (2011)

Background:  MicroRNAs play a major role in angiogenesis. Though there is limited data on their clinical relevance, they potentially contribute to subclinical atherosclerosis. We investigated the correlation between coronary artery plaque burden assessed by Computed Tomography (CT) and plasma levels of endothelial miR-92a and miR-126 and smooth muscle miR-145 and miR-155 in patients without known coronary artery disease (CAD).   Methods:  33 patients (26 male, mean age 61±13y) underwent Dual Source-Computed Tomography for the exclusion of CAD. Plasma levels of miR-92a, miR-126, miR-145 and miR-155 were determined before scan, and miRNAs were quantified by real time-PCR. The levels were normalized to spiked c.elegans miRNA to control for the RNA extraction efficacy. CT data sets were quantified, classifying plaques by the predominantly present plaque type and by the number of plaques.   Results:  MiR-92a, miR-126 and inflammation-related miR-155 were not significantly different in patient subgroups. However, there was a trend towards higher levels of miR-92 in patients with calcified plaques. Levels of miR-145 were significantly regulated: MiR-145 levels were reduced in patients with coronary plaques (0.09±0.07, n=24) if compared to patients without (0.23±0.18, n=9, p=0.006). Lowest miR-145 levels were detected in patients with non-calcified and mixed plaques (0.05±0.04, n=6 and 0.07±0.06, n=10). Moreover, the number of coronary plaques negatively influenced miR-145 levels (p=0.02 for >1 plaque vs. no plaque, Figure).   Conclusion:  Coronary plaque identified by CT is associated with dysregulated levels of miRNAs. Endothelial and inflammation-derived miRNAs are not significantly changed, but miR-145, which regulates smooth muscle phenotypes, is reduced in subjects with atherosclerotic lesions. Since miR-145 is known to protect against atherosclerosis, the detection of suppressed miR-145 levels may help to identify vulnerable atherosclerotic lesions.
Abstract 253: Accuracy of Detecting Chest Compression Rate from the Thoracic Impedance Data Recorded Through Chest Pads
Authors: Reza Firoozabadi, Eric Helfenbein, Saeed Babaeizadeh
Journal: Circulation (2012)

Background To assist healthcare providers in performing quality CPR, devices such as Q-CPR TM measurement and feedback tool can be used with defibrillators. However, such devices are not always present, but almost every defibrillator records impedance signal through chest pads. Therefore, being able to detect the chest compression (CC) rate from the thoracic impedance signal in real-time can be valuable in practice. The real-time rate, for example, can be used to provide feedback to the rescuer or to remove compression artifact from ECG during CPR to shorten the time between last compression and the defibrillation shock. Objective To detect the chest compression rate from thoracic impedance signal and compare it to the true rate from compression signal. Methods Recordings of 175 out of hospital cardiac arrest (OHCA) patients older than 18 years were used. The database was collected using Laerdal HeartStart 4000 defibrillators in 6 ambulances in 3 European regions between March 2002 and October 2003 for prospective study of OHCA patients. The defibrillators had an extra chest pad mounted on the lower part of the sternum with an accelerometer and a pressure sensor to record the compression signal which by analyzing it the true compression rate was determined. The thoracic impedance signal from the chest pads was also recorded and analyzed to calculate the compression rate. Results At the end of each 10-second segment of the data the compression rate was calculated from the thoracic impedance and was compared to the true rate in the same interval. The difference between the true and calculated rate was 2±13 compression per minute (cpm). For 95% of the data segments the difference was lower than 20 cpm, and only 9% of the segments had a rate difference larger than 10 cpm. Conclusion In the absence of CPR measurement and feedback tools, it is possible to accurately detect the chest compression rate using only the thoracic impedance signal which is usually recorded through the defibrillator chest pads. This can potentially be used as a software-only CPR feedback tool to help improve the quality of CPR delivery. However, unlike devices such as Q-CPR TM , this method does not give any feedback on the compression depth or ventilation volume and rate.
循证医学带给我们什么？——开端良好，任重道远
Authors: Sharon, Straus, Giselle, Jones, 卫茂玲（译）, 刘鸣（校）
Journal: BMJ (2005)

循证医学（EBM）的发展是否促进了医学实践方式的转变，是否改善了医疗保健的质量？迄今为止，有什么证据来支持上述问题的答案呢？我们所收集的资料显示，答案并非直截了当，要确定循证医学运动的成功为时尚早。然而，我们希望通过这期杂志来回顾过去10余年EBM实践和教学的进展，并使大家关注那些正在努力实践的领域，从而引发一场争论。
Predictors of 30-day Mortality after Transcatheter Aortic Valve Implantation - Results from the Expanded Evaluation Registry with the 3rd Generation CoreValve ReValving System
Authors: N Piazza, R Lange, S Bleiziffer, E Grube, U Gerckens, S Windecker, P Wenaweser, H Sievert, D Moss, C Tamburino, G Ussia, A Ramondo, J Kovacs, O Luha, F Ettori, L Niccoli, AS Petronio, M de Carlo, L Verhees, A Cardeno, JC Laborde, PW Serruys, P de Jaegere
Journal: Circulation (2009)
Erratum: TET1 is a tumor suppressor of hematopoietic malignancy
Authors: Luisa Cimmino, Meelad M Dawlaty, Delphine Ndiaye-Lobry, Yoon Sing Yap, Sofia Bakogianni, Yiting Yu, Sanchari Bhattacharyya, Rita Shaknovich, Huimin Geng, Camille Lobry, Jasper Mullenders, Bryan King, Thomas Trimarchi, Beatriz Aranda-Orgilles, Cynthia Liu, Steven Shen, Amit K Verma, Rudolf Jaenisch, Iannis Aifantis
Journal: Nature Immunology (2015)
Religious beliefs and practices among 52 psychiatric inpatients in Minnesota
Authors: J Kroll, W Sheehan
Journal: American Journal of Psychiatry (1989)

The authors studied the religious beliefs, practices, and experiences of 52 psychiatric inpatients. The rate of belief in the major tenets of faith (God, the Devil, and an afterlife) was uniformly high and in accord with national and local public poll results. Patients with depressive and anxiety disorders tended to score lower than those with other diagnoses on a wide variety of indexes of religion. The authors conclude that religion is an important factor in most patients' lives and that individual inquiry and systematic research into this neglected area are both feasible and important.
Abstract 14239: Testing of Genetic Variants Influencing Heart Rate and Electrocardiographic Indices of Conduction and Repolarization for Modulation of Risk of Acute Ischemia-Related Ventricular Fibrillation
Authors: Raha Pazoki, Michael W Tanck, Jonas S de Jong, Lukas R Dekker, Arthur A Wilde, Connie R Bezzina
Journal: Circulation (2010)

Background: Sudden cardiac death is a leading mode of death in adults in the Western world. A large proportion of these deaths are caused by ventricular fibrillation (VF) during acute myocardial is...
Abstract 18582: Left Atrial Mechanics in Heart Failure With Preserved Ejection Fraction: Prognostic Utility of Left Atrial Strain and Tissue Doppler A’ Velocities
Authors: Benjamin H Freed, Frank G Aguilar, Kameswari Maganti, Michael A Burke, Sanjiv J Shah
Journal: Circulation (2013)

Background: Left atrial (LA) size and function are useful parameters for identifying patients with heart failure and preserved ejection fraction (HFpEF). In HFpEF patients, the prognostic utility of poor LA mechanics (reduced LA strain or reservoir function and/or tissue Doppler imaging [TDI] A’ velocities) has not been explored. We hypothesized that reduced LA strain and A’ velocities are independently associated with adverse outcomes. Methods: We prospectively evaluated LA mechanics in 86 patients with HFpEF. All patients underwent comprehensive echocardiography, including Doppler, TDI, and speckle-tracking analysis. The following measurements were made in all patients: TDI systolic (S’), early diastolic (E’), and late diastolic/atrial (A’) velocities as well as LV global longitudinal (LVGLS), RV free wall (RVFWS), and global longitudinal LA peak positive strain. Patients were followed every 3 months for the composite outcome of heart failure hospitalization, cardiovascular hospitalization, and death. Unadjusted and multivariable-adjusted Cox proportional hazards analyses were used to determine the prognostic utility of each parameter. Results: The mean age was 63±13 y, 71% female. Patients had objective evidence of HFpEF (LVEF 62±7%; PCWP 25±11 mmHg). Reduced LA peak positive strain and A’ velocities were both associated with adverse outcomes (Figure). LA peak positive strain: unadjusted HR=2.1 (95% CI 1.3-3.2; P=0.001); adjusted HR=1.8 (95% CI 1.1-3.0; P=0.015) after controlling for age, sex, LA volume index, atrial fibrillation, CAD, and GFR. A’ velocities: unadjusted HR 2.1 (95% CI 1.4-3.4; P=0.001); adjusted HR 2.3 (95% CI 1.4-4.0; P=0.002). None of the other parameters (E’, S’, LVGLS, or RVFWS) were significantly associated with adverse outcomes. Conclusions: LA reservoir function and TDI A’ velocities are independently associated with adverse outcomes in HFpEF patients.
Tracking Subclonal Mutations in IGHV-Mutated CLL with Progressive Disease
Authors: Matthew JJ Rose-Zerilli, Gibson Jane, Jun Wang, William J Tapper, Helen Parker, Anton Parker, Zadie Davis, Anne Catherine Gardiner, Jade Forster, Andrew J Steele, Renata Walewska, Helen McCarthy, Andrew Collins, David G Oscier, Jonathan C Strefford
Journal: Blood (2014)