STEVENS-JOHNSON SYNDROME, A VARIATION OF ERYTHEMA MULTIFORME EXSUDATIVUM (HEBRA): A REPORT OF TWO CASES
Authors: H S WENTZ, H H SEIPLE
Journal: Annals of Internal Medicine (1947)

Case Reports1 February 1947STEVENS-JOHNSON SYNDROME, A VARIATION OF ERYTHEMA MULTIFORME EXSUDATIVUM (HEBRA): A REPORT OF TWO CASESHENRY S. WENTZ, M.D., HARVEY H. SEIPLE, M.D., F.A.C.P.HENRY S. WENTZ, M.D.Search for more papers by this author, HARVEY H. SEIPLE, M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-26-2-277 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTwo cases are presented—the first a syndrome of ulceromembranous stomatitis, purulent conjunctivitis, urethritis, and signs of constitutional toxicity; the second an eruptive bullous type febrile disease associated with stomatitis and ophthalmia. Both cases conform to the picture described by Stevens and Johnson. Stevens and Johnson3 in 1922 felt that their syndrome of an eruptive febrile disease associated with stomatitis and purulent conjunctivitis was a distinct clinical entity. Controversy exists, however, as to whether the syndrome should be differentiated from erythema multiforme exsudativum.Fletcher and Harris1in 1945 and Keil2in 1940 have presented excellent historical reviews. Erythemas were first described...Bibliography1. FLETCHERHARRIS MWRC: Erythema exsudativum multiforme (Hebra)—bullous type, Jr. Pediat., 1945, xxvii, 465-478. CrossrefGoogle Scholar2. KEIL H: Erythema multiforme exsudativum (Hebra), a clinical entity associated with systemic features, Ann. Int. Med., 1940, xiv, 450. Google Scholar3. STEVENSJOHNSON AMFC: A new eruptive fever associated with stomatitis and ophthalmia: report of two cases in children, Am. Jr. Dis. Child., 1922, xxiv, 526-533. CrossrefGoogle Scholar4. KOKE MP: Conjunctivitis in erythema exsudativum multiforme, Arch. Ophth., 1941, xxv, 78-88. 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KOVE S: Stevens Johnson syndrome (eruptive fever with stomatitis and conjunctivitis), Am. Jr. Med. Sci., 1945, ccx, 611-623. CrossrefGoogle Scholar18. ERGER BD: Erythema multiforme pluriorificialis (Stevens Johnson disease), Mil. Surg., 1944, xcv, 308-312. Google Scholar19. MCCARTHY L: Histopathology of skin diseases, 1931, C. V. Mosby Co., St. Louis, p. 137. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Lancaster, Pennsylvania*Received for publication March 28, 1946. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byThe Nail in Dermatological DiseaseDiseases of the Nails in ChildrenBlindness, Anonychia, and Oral Mucosal Scarring as Sequelae of the Stevens-Johnson SyndromeDrugs as etiologic factors in the Stevens-Johnson syndromePain in the Extremities, Dysesthesia, PolyalgiaDas Stevens-Johnson-Syndrom.ERYTHEMA MULTIFORME EXUDATIVUM WITH MUCOUS MEMBRANE INVOLVEMENT: WITH A REPORT OF THREE CASESSTEVENS-JOHNSON SYNDROME TREATED WITH A.C.T.HThe Ocular Complications of Erythema Exudativum Multiforme*Further Studies of Stevens-Johnson's Disease*ERYTHEMA MULTIFORME EXUDATIVUM (THE STEVENS-JOHNSON SYNDROME)The diagnosis of pemphigus by its oral signsErythema multiforme exudativum:Stevens-Johnson syndromePneumonia and erythema multiforme exudativumAn unusual eruptive fever involving the skin and mucous membranesAn Eruptive Fever Involving the Skin and Mucous Membranes (Stevens–Johnson Disease) 1 February 1947Volume 26, Issue 2Page: 277-283KeywordsConjunctivitisErythemaToxicityUlcers ePublished: 1 December 2008 Issue Published: 1 February 1947 PDF downloadLoading ...