Testosterone Metabolism in Idiopathic Hirsutism
Authors: JOHN J. DELLER
Journal: Annals of Internal Medicine (1965)

Article1 September 1965Testosterone Metabolism in Idiopathic HirsutismJOHN J. DELLER JR., LAURENCE C. WEGIENKA, M.D., NICHOLAS F. CONTE, JORGE M. ROSNER, M.D., PETER H. FORSHAM, M.D.JOHN J. DELLER JR.Search for more papers by this author, LAURENCE C. WEGIENKA, M.D.Search for more papers by this author, NICHOLAS F. CONTESearch for more papers by this author, JORGE M. ROSNER, M.D.Search for more papers by this author, PETER H. FORSHAM, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-63-3-369 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe recent development of methods for measuring testosterone in both the blood and the urine (1-6) has made possible a new approach to the problem of diagnosis in idiopathic hirsutism. This paper describes studies in 35 cases of hirsutism of various causes, including some that must still be classified as "idiopathic," and 15 appropriate control cases. The dynamics of testosterone metabolism were studied in these women during stimulation and suppression of the adrenals and ovaries. In addition to testosterone, urinary 17-hydroxycorticosteroids (17-OHCS), 17-ketosteroids (17-KS), creatinine, and pregnanetriol were measured. The value of urinary testosterone studies in the evaluation of idiopathic...References1. CAMACHOMIGEON ALCJ: Isolation, identification and quantitation of testosterone in the urine of normal adults and in patients with endocrine disorders. J. Clin. Endocr. 23: 301, 1963. CrossrefGoogle Scholar2. VERMEULENVERPLANCKE AJC: A simple method for the determination of urinary testosterone excretion in human urine. Steroids 2: 453, 1963. CrossrefGoogle Scholar3. 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Author, Article, and Disclosure InformationAffiliations: From the Metabolic Research Unit and Department of Medicine, University of California School of Medicine, San Francisco, Calif.These studies were done in the General Clinical Research Center under University of California grant FR-79 from the Division of Research Facilities and Resources, U. S. Public Health Service, and were supported by grants from The Upjohn Company, Kalamazoo, Mich., and Lange Medical Publications, Los Altos, Calif.Requests for reprints should be addressed to Peter H. Forsham, M.D., Metabolic Research Unit, University of California School of Medicine, San Francisco, Calif. 94122. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByEndokrine Aspekte des HochdrucksEvidence for adrenal and/or ovarian dysfunction as a possible etiology of idiopathic hirsutismEndocrine Aspects of HypertensionEndokrine Aspekte des HochdrucksThe Hirsute Person: A CommentaryHirsutism: A Review of the Genetic and Experimental AspectsAndrogen production and metabolism in normal and virilized womenPlasma testosterone stimulation-suppression dynamics in hirsute womenHirsutismUrinary testosterone fractionsHyperfunctioning Adrenocortical DiseasesStudies of female hirsutism 1 September 1965Volume 63, Issue 3Page: 369-376KeywordsBloodCreatinineExcretionMedical servicesOvariesResearch facilitiesTestosteroneUrine Issue Published: 1 September 1965 PDF DownloadLoading ...