tbuckley/cabot-search huggingface dataset:
The vulnerability and limitations of impact factor in evaluating quality
Authors: A. Agarwal, R. Agarwal
Journal: Journal of the Royal Society of Medicine (2007)

We enjoyed reading the article by Chew et al. (JRSM 2007; 100: 142-150).1 The article clearly highlights the vulnerability and limitations of impact factor in evaluating the quality of journals. A well-informed and careful use of this impact data is thus essential. Thompson Scientific agrees that there are limitations attached to impact factors, and emphasize that there is no substitute for informed peer review.2

Many scholars have suggested that Thompson should count citations only to original research articles, eliminating the problem of news, stories, editorials, reviews and other kind of material which can influence the citation rates falsely. In 2006, Bollen et al. proposed the PageRank algorithm used by Google to distinguish the quality of citations and hence improve impact factor calculations.3

There is a definite need for other methods for analyzing bibliographic material and assessing its quality. Instead of citations, as being used in calculating impact factor, one can ask the peer reviewers to rate an accepted article over a score of hundred at the time of its review. Since articles are usually evaluated on several quantitative and qualitative parameters—for example, originality, clarity, content, methodology, discussion—this score will give a fair idea of ‘quality’ of the article. Scores from two or more blind reviewers will increase the reliability of the score. The score thus calculated can be published along with the accepted article. Since the editorials, reviews, letters, etc., are not original articles, this score cannot be calculated for the same.
The response to prednisolone in atrophic gastritis: a possible effect on non-intrinsic factor-mediated vitamin B12 absorption
Authors: R. G. Strickland, J. M. Fisher, K. Lewin, K. B. Taylor
Journal: Gut (1973)

The administration of prednisolone did not affect absorption of vitamin B(12) and gastric secretion of intrinsic factor in nine subjects with normal gastric mucosa, or in five with chronic superficial gastritis. No gastric morphological changes were observed in either group. In contrast, four of seven patients with pernicious anaemia showed improvement in absorption of vitamin B(12) during prednisolone administration for periods of two to 10 months. No consistent changes in gastric mucosal morphology were noted. An additional five patients were studied intensively during one month of prednisolone administration. In three, absorption of vitamin B(12) was restored to within the normal range between eight and 13 days after the commencement of the drug. The improvement was not paralleled by enhancement of secretion of intrinsic factor or other vitamin B(12) binders. Suppression of intrinsic factor antibodies in serum and gastric juice did not occur consistently in those patients showing a functional response.
Secondary Amenorrhea After Hodgkin’s Lymphoma Is Influenced by Age at Treatment, Stage of Disease, Chemotherapy Regimen, and the Use of Oral Contraceptives During Therapy: A Report From the German Hodgkin’s Lymphoma Study Group
Authors: Karolin Behringer, Kai Breuer, Thorsten Reineke, Michael May, Lucia Nogova, Beate Klimm, Tatiana Schmitz, Ludwig Wildt, Volker Diehl, Andreas Engert
Journal: Journal of Clinical Oncology (2005)

Long-term survivors of successfully treated Hodgkin's lymphoma (HL) are at risk for late complications. Among these, infertility for female patients is of major importance. The subject of this analysis is to evaluate the menstrual status after HL therapy.From 1994 to 1998, the German Hodgkin's Lymphoma Study Group conducted clinical trials for early-, intermediate-, and advanced-stage HL (trials HD7 to HD9) involving a total of 3,186 patients. A survey was carried out to evaluate the menstrual status after therapy. The following factors were assessed concerning their influence on amenorrhea: age, treatment, stage, and the use of oral contraceptives during chemotherapy.A total of 405 women aged younger than 40 years answered the study questions. After a median follow-up of 3.2 years, 51.4% of the women receiving eight cycles of dose-escalated bleomycin, etoposide, doxorubicin, cyclophosphamide, vincristine, procarbazine, and prednisone (BEACOPP) had continuous amenorrhea. Amenorrhea was significantly more frequent after dose-escalated BEACOPP compared with doxorubicin, bleomycin, vinblastine, and dacarbazine; cyclophosphamide, vincristine, procarbazine, prednisone, doxorubicin, bleomycin, vinblastine, and dacarbazine; or standard BEACOPP (P = .0066). Amenorrhea after therapy was most pronounced in women with advanced-stage HL (P < .0001), in women older than 30 years at treatment (P = .0065), and in women who did not take oral contraceptives during chemotherapy (P = .0002).Most women who are treated for advanced-stage HL experience amenorrhea after therapy. Amenorrhea is significantly more frequent in women with advanced-stage HL receiving eight cycles of dose-escalated BEACOPP and in women older than 30 years at first treatment. Furthermore, the data show a statistical association between the use of oral contraceptives and return of menstrual cycle, which is subject to further investigation.
THE ABUSES AND USES OF VENESECTION IN THE PRACTICE OF MEDICINE.
Authors: ROBERT REYBURN
Journal: JAMA (1903)

Though for centuries venesection was considered one of the most valuable methods to be employed in the cure of disease, it has now fallen entirely out of use. The present generation of physicians, indeed, has seen so little of the practice of blood letting as a therapeutic agent that it is hard for them to realize how universally it was used even as late as the middle of the last century. At the time the writer commenced the study of medicine (about fifty years ago) the favorite text-book used by medical students was Watson's "Practice of Medicine." It was indeed a charming book, and one that for beauty of style and literary diction could not be surpassed. It was, however, in some respects a most discouraging book. Watson would give the most vivid pictures of the symptoms and progress of diseases and yet when it came to their treatment all
Changing lifelong habits of elderly people.
Authors: D. L. Cohen, S. Fowlie
Journal: BMJ (1992)

24 10O.'The difference between this figure and the estimate quoted in my editorial is attributable to the inclusion of additional charges for extended acute hospital care and different assumptions about the life expectancy of survivors (5 v 10 years).Even so, the cost of HA-lA still compares favourably with that of many other widely accepted medical mterventions.
He's Still Alive!
Authors: Ted Listokin
Journal: Annals of Internal Medicine (1994)

On Being a Doctor15 January 1994He's Still Alive!Ted Listokin, MDTed Listokin, MDNew York University Medical Center, New York, NY 10016.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-120-2-199401150-00009 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail Just as an exhausting on-call day is ending, with only enough energy to ponder the slumber that lies ahead, I hear the beeper go off. It is an outside line; the doctor from the intensive care unit answers.“His pressure has been dropping all afternoon,” he explains, “and on maximum vasopressors, I don't expect him to live through the night. You might want to come in now”.I am a bit shaken but not surprised, and, having prepared for this news, I race for the door, purging my mind of the day's events in anticipation of what is to come. ... Author, Article, and Disclosure InformationAuthors: Ted Listokin, MDAffiliations: New York University Medical Center, New York, NY 10016.Corresponding Author: Ted Listokin, MD, 333 East 30 Street, New York, NY 10016. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 15 January 1994Volume 120, Issue 2Page: 159-160KeywordsBlood pressureEmotionsHeartHeart rateIntensive care unitsNursesPneumoniaThoraxVentilatorsVital signs ePublished: 15 August 2000 Issue Published: 15 January 1994 Copyright & PermissionsCopyright © 1994 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Safety of Long-Acting Beta-Agonists — An Urgent Need to Clear the Air
Authors: Fernando D. Martinez
Journal: New England Journal of Medicine (2005)

Eleven years after the first long-acting beta-agonist, salmeterol, was approved for sale in the United States, the Food and Drug Administration (FDA) has issued a stern public health advisory alerting "health care professionals and patients that these medicines may increase the chance of severe asthma episodes, and death when those episodes occur" (www.fda.gov/cder/drug/advisory/LABA.htm). The announcement followed a July 2005 meeting of an FDA advisory committee on this topic. What are the consequences of this advisory for the treatment of asthma?Currently, inhaled corticosteroids are the most effective treatment for the symptoms of persistent asthma. However, in patients with severe disease, . . .
Spiro-Ergometry in Patients suffering from Bechterew's Disease
Authors: G. J. Van Weerden, S. A. Den Oudsten, A. L. De Groot, W. Van Der Veere
Journal: Annals of the Rheumatic Diseases (1960)

Rogan, Needham, and McDonald (1955) per- formed lung-function tests on patients suffering from Bechterew's disease; their studies did not, however, include measurements during exercise.Julian, Travis, and Bayles (1959) also performed lung-function tests at rest only, but they advocated investigations during strain.Renzetti, Nicholas, Dutton, and Jivoff (1960) mention the occurrence of hyperventilation of patients with Bechterew's disease during exercise, but they did not describe how the exercise was performed.The functional condition of an organ or organic system is best evaluated when this organ or system is submitted to a certain degree of strain.Spiro-ergometry has therefore been carried out in this clinic since 1954 in a group of patients suffering from Bechterew's disease, and the following questions were considered: (a) To what extent do patients with Bechterew's disease differ from normal subjects?(b) How should this difference be explained?(c) What is the prognosis for the patients?Material and Methods The group consisted of 29 male patients with typical Bechterew's disease.They showed no evidence of pulmonary or cardiac disease, as judged from their history and normal routine physical examination.The average age at the time of onset of symptoms was 31 years, and the average duration of disease was 121 years.The sacro-iliac joints showed ankylosis in seventeen, rosary formation in four, and sclerosis in seven.The Rose-Waaler sheep cell agglutination test was positive in two and negative in 26 cases, and was not done in one case.Spiro-ergometry was carried out with the aid of a bicycle-ergometer, the patient being connected with a spirograph.
The Influence of Resection and Aneuploidy on Mortality in Oral Leukoplakia
Authors: Jon Sudbø, Scott M. Lippman, J. Jack Lee, Li Mao, Wanja Kildal, Asle Sudbø, Simone Sagen, Magne Bryne, Adel El-Naggar, Björn Risberg, Jan F. Evensen, Albrecht Reith
Journal: New England Journal of Medicine (2004)

Although the standard treatment of oral leukoplakia ranges from watchful waiting to complete resection, the value of these approaches is unknown.
A Vacation Fit for a Coóaka
Authors: Nancy L. Greengold
Journal: JAMA (1993)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
What can we learn from highly developed special skills?
Authors: Michael Rutter
Journal: Behavioral and Brain Sciences (1998)

Skills cannot be divided into the innate and the acquired. Also, genetic effects may not come into play until well after early childhood, and evocative gene-environment correlations are to be expected. Special talents are common in autism and warrant more detailed study, but whether they have the same meaning as talents in nonautistic individuals is not known.
Prognostically relevant natural killer cell-mediated immunoediting in acute myeloid leukemia
Authors: Christopher J Chan, Daniel M Andrews, Mark J Smyth, Paul J Neeson, David S Ritchie
Journal: Journal for ImmunoTherapy of Cancer (2013)

Meeting abstracts Natural Killer (NK) cells contribute to the control of cancer through immunosurveillance and may influence phenotypic sculpting of cancer through immunoediting. NK cells may also contribute to the control of hematological malignancies such as acute myeloid leukemia (AML) following
Lower tidal volume strategy (≈3 ml/kg) combined with extracorporeal CO2 removal versus ‘conventional’ protective ventilation (6 ml/kg) in severe ARDS
Authors: Thomas Bein, Steffen Weber-Carstens, Anton Goldmann, Thomas Müller, Thomas Staudinger, Jörg Brederlau, Ralf Muellenbach, Rolf Dembinski, Bernhard M. Graf, Marlene Wewalka, Alois Philipp, Klaus-Dieter Wernecke, Matthias Lubnow, Arthur S. Slutsky
Journal: Intensive Care Medicine (2013)

Acute respiratory distress syndrome is characterized by damage to the lung caused by various insults, including ventilation itself, and tidal hyperinflation can lead to ventilator induced lung injury (VILI). We investigated the effects of a low tidal volume (V T) strategy (V T ≈ 3 ml/kg/predicted body weight [PBW]) using pumpless extracorporeal lung assist in established ARDS. Seventy-nine patients were enrolled after a ‘stabilization period’ (24 h with optimized therapy and high PEEP). They were randomly assigned to receive a low V T ventilation (≈3 ml/kg) combined with extracorporeal CO2 elimination, or to a ARDSNet strategy (≈6 ml/kg) without the extracorporeal device. The primary outcome was the 28-days and 60-days ventilator-free days (VFD). Secondary outcome parameters were respiratory mechanics, gas exchange, analgesic/sedation use, complications and hospital mortality. Ventilation with very low V T’s was easy to implement with extracorporeal CO2-removal. VFD’s within 60 days were not different between the study group (33.2 ± 20) and the control group (29.2 ± 21, p = 0.469), but in more hypoxemic patients (PaO2/FIO2 ≤150) a post hoc analysis demonstrated significant improved VFD-60 in study patients (40.9 ± 12.8) compared to control (28.2 ± 16.4, p = 0.033). The mortality rate was low (16.5 %) and did not differ between groups. The use of very low V T combined with extracorporeal CO2 removal has the potential to further reduce VILI compared with a ‘normal’ lung protective management. Whether this strategy will improve survival in ARDS patients remains to be determined (Clinical trials NCT 00538928).
Gene Expression of Adiponectin Receptors in Human Visceral and Subcutaneous Adipose Tissue Is Related to Insulin Resistance and Metabolic Parameters and Is Altered in Response to Physical Training
Authors: Matthias Blüher, Catherine J. Williams, Nora Klöting, Alex Hsi, Karen Ruschke, Andreas Oberbach, Mathias Fasshauer, Janin Berndt, Michael R. Schön, Alicja Wolk, Michael Stumvoll, Christos S. Mantzoros
Journal: Diabetes Care (2007)

Adiponectin receptors 1 and 2 (AdipoR1 and AdipoR2, respectively) mediate the effects of adiponectin on glucose and lipid metabolism in vivo. We examined whether AdipoR1 and/or AdipoR2 mRNA expression in human adipose tissue is fat-depot specific. We also studied whether their expression in visceral and subcutaneous fat depots is associated with metabolic parameters and whether their expression is regulated by intensive physical exercise.We determined metabolic parameters and assessed AdipoR1 and AdipoR2 mRNA expression using quantitative real-time PCR in adipose tissue in an observational study of 153 subjects and an interventional study of 60 subjects (20 each with normal glucose tolerance, impaired glucose tolerance, and type 2 diabetes) before and after intensive physical training for 4 weeks.AdipoR1 and AdipoR2 mRNA expression is not significantly different between omental and subcutaneous fat, but their expression is several-fold lower in adipose tissue than in muscle. AdipoR2 mRNA expression in visceral fat is highly correlated with its expression in subcutaneous fat. AdipoR2 mRNA expression in both visceral and subcutaneous fat is positively associated with circulating adiponectin and HDL levels but negatively associated with obesity as well as parameters of insulin resistance, glycemia, and other lipid levels before and after adjustment for fat mass. Physical training for 4 weeks resulted in increased AdipoR1 and AdipoR2 mRNA expression in subcutaneous fat.AdipoR2 mRNA expression in fat is negatively associated with insulin resistance and metabolic parameters independently of obesity and may mediate the improvement of insulin resistance in response to exercise.
Preemployment Drug Screening and Employment Outcome
Authors: Joel R. L. Ehrenkranz
Journal: JAMA (1991)

<h3>To the Editor. —</h3> In preemployment drug screening it is important to ensure against urine sample substitution. Documenting specimen authenticity is most frequently done by measuring urine temperature.<sup>1,2</sup> Zwerling et al<sup>3</sup>state that urine temperature measurements were performed as part of the procedure of collecting urine specimens. The authors claim that detection of substituted urine was a "rare event." However, the article does not specify how urine temperature was measured. This is important because most methods used to determine urine temperature in commercial drug testing are unable to discriminate fresh from substituted specimens.<sup>4</sup>The cutoff value of 32.8°C used by Zwerling et al has been shown to provide almost no discrimination between real and bogus specimens.<sup>5</sup>Such a lack of precision on the part of the authors could have led to a systematic misclassification of subjects due to a large number of falsenegative drug test results.
EXTRACARDIAC FONTAN COMPLETION WITH AUTOLOGOUS PERICARDIAL PEDICLE: FEASIBILITY AND OUTCOME IN CHILDREN LESS THAN 2 YEARS OF AGE
Authors: Brent M. Gordon, Tiffany Tse, Andrew Souza, Jennifer Newcombe, Noha Daher, Nahidh Hasaniya, Leonard Bailey, Anees Razzouk
Journal: Journal of the American College of Cardiology (2012)
Arteriolar narrowing as predictor of hypertension: Blood pressure and weight gain are better
Authors: Arnaud Chiolero
Journal: BMJ (2004)

EDITOR—Wong et al studied the association between retinal vessel diameters and risk of hypertension.1 Some points would have deserved discussion.

   ![][1]    ![][2] 

Narrowed (left) and normal (right) retinal arterioles

Firstly, evidence shows that blood pressure is one of the strongest predictors of the risk of progression towards hypertension. Thus, in the Framingham cohort study,2 subjects with a normal …

 [1]: /embed/graphic-1.gif
 [2]: /embed/graphic-2.gif
The developmental program of human dendritic cells is operated independently of conventional myeloid and lymphoid pathways
Authors: Fumihiko Ishikawa, Hiroaki Niiro, Tadafumi Iino, Shuro Yoshida, Noriyuki Saito, Shinya Onohara, Toshihiro Miyamoto, Hiroko Minagawa, Shin-ichiro Fujii, Leonard D. Shultz, Mine Harada, Koichi Akashi
Journal: Blood (2007)
Retinal Detachment and Fluoroquinolones
Authors: Rajesh C. Rao, Brian J. Dlouhy
Journal: JAMA (2012)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Journals JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Meta-analysis of endoscopic submucosal dissection versus endoscopic mucosal resection for tumors of the gastrointestinal tract
Authors: Y. Cao, C. Liao, A. Tan, Y. Gao, Z. Mo, F. Gao
Journal: Endoscopy (2009)

Background and study aims: Endoscopic submucosal dissection (ESD) has been developed to overcome the limitations of endoscopic mucosal resection (EMR). We aimed to compare the outcomes of these two methods.