Factors Associated With Lack of Viral Suppression at Delivery
Authors: Anna Calzi, Francesca Bisio, Daniele Roberto Giacobbe
Journal: Annals of Internal Medicine (2015)

Letters16 June 2015Factors Associated With Lack of Viral Suppression at DeliveryAnna Calzi, MD, Francesca Bisio, MD, PhD, and Daniele Roberto Giacobbe, MDAnna Calzi, MDFrom Clinica Malattie Infettive, IRCCS Azienda Ospedaliera Universitaria San Martino-IST, Università di Genova, Genova, Italy.Search for more papers by this author, Francesca Bisio, MD, PhDFrom Clinica Malattie Infettive, IRCCS Azienda Ospedaliera Universitaria San Martino-IST, Università di Genova, Genova, Italy.Search for more papers by this author, and Daniele Roberto Giacobbe, MDFrom Clinica Malattie Infettive, IRCCS Azienda Ospedaliera Universitaria San Martino-IST, Università di Genova, Genova, Italy.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/L15-0178 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:Katz and colleagues (1) assessed the predictors of detectable HIV viral load (VL) at delivery among treatment-naive women initiating highly active antiretroviral therapy (HAART) during pregnancy. One factor associated with lack of viral suppression at delivery was a high pretreatment VL, especially among women who initiated HAART in the third trimester (1). We compared these results—obtained in the Western hemisphere—with our experience in a resource-limited country (2) where even more treatment-naive women initiate HAART late during pregnancy, thus possibly accounting for high rates of detectable VL at delivery.From 2009 to 2012, we enrolled 802 HIV-positive pregnant ...References1. Katz IT, Leister E, Kacanek D, Hughes MD, Bardeguez A, Livingston E, et al. Factors associated with lack of viral suppression at delivery among highly active antiretroviral therapy-naive women with HIV: a cohort study. Ann Intern Med. 2015;162:90-9. [PMID: 25599347] doi:10.7326/M13-2005 LinkGoogle Scholar2. Bisio F, Masini G, Blasi Vacca E, Calzi A, Cardinale F, Bruzzone B, et al; Kento-Mwana group. Effectiveness of a project to prevent HIV vertical transmission in the Republic of Congo. J Antimicrob Chemother. 2013;68:1862-71. [PMID: 23587655] doi:10.1093/jac/dkt102 CrossrefMedlineGoogle Scholar3. Kuhn L, Kasonde P, Sinkala M, Kankasa C, Semrau K, Scott N, et al. Does severity of HIV disease in HIV-infected mothers affect mortality and morbidity among their uninfected infants? Clin Infect Dis. 2005;41:1654-61. [PMID: 16267740] CrossrefMedlineGoogle Scholar Author, Article, and Disclosure InformationAuthors: Anna Calzi, MD; Francesca Bisio, MD, PhD; Daniele Roberto Giacobbe, MDAffiliations: From Clinica Malattie Infettive, IRCCS Azienda Ospedaliera Universitaria San Martino-IST, Università di Genova, Genova, Italy.Disclosures: Authors have disclosed no conflicts of interest. Forms can be viewed at www.acponline.org/authors/icmje/ConflictOf InterestForms.do?msNum=L15-0178. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoFactors Associated With Lack of Viral Suppression at Delivery Among Highly Active Antiretroviral Therapy–Naive Women With HIV Ingrid T. Katz , Erin Leister , Deborah Kacanek , Michael D. Hughes , Arlene Bardeguez , Elizabeth Livingston , Alice Stek , David E. Shapiro , and Ruth Tuomala Factors Associated With Lack of Viral Suppression at Delivery Ingrid T. Katz , David E. Shapiro , and Ruth Tuomala Metrics 16 June 2015Volume 162, Issue 12Page: 874KeywordsConflicts of interestDisclosureFactor analysisHighly active antiretroviral therapyHIVInfantsOdds ratioPregnancyTreatment guidelinesViral load ePublished: 16 June 2015 Issue Published: 16 June 2015 Copyright & PermissionsCopyright © 2015 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...