tbuckley/cabot-search huggingface dataset:
Chronic generalized fibrotic skin lesions from disseminated leishmaniasis caused by <i>Leishmania martiniquensis</i> in two patients from northern Thailand infected with HIV
Authors: S. Chiewchanvit, N. Tovanabutra, N. Jariyapan, M.D. Bates, P. Mahanupab, M. Chuamanochan, A. Tantiworawit, P.A. Bates
Journal: British Journal of Dermatology (2015)

Leishmaniasis is a newly emerging infection in Thailand. Most of the previous human cases have presented with the clinical features of visceral leishmaniasis and were mainly found in southern Thailand. Here we report the first two patients from northern Thailand presenting with disseminated cutaneous leishmaniasis.To determine the nature of the infection of leishmaniasis and to identify the species of parasite responsible.Clinical investigations included the taking of biopsy samples and histology. Parasitological diagnosis was performed by establishment of Leishmania promastigote cultures, and identification was performed by DNA sequencing of four independent gene loci (ribosomal RNA internal transcribed spacer 1; large subunit of RNA polymerase II; heat shock protein 70; RPL23a intergenic sequence).Both patients were infected with HIV, and had multiple cutaneous lesions and accompanying visceral leishmaniasis. They had similar cutaneous manifestations characterized by chronic generalized fibrotic lesions, which were more prominent on traumatic areas. In both patients the parasite was identified as Leishmania martiniquensis. This is a recently described species that is distinct and only distantly related to the classical agents of cutaneous leishmaniasis in Asia (Leishmania major and Leishmania tropica) or of visceral leishmaniasis (Leishmania donovani and Leishmania infantum). Each patient responded well to therapy with intravenous amphotericin B followed by oral itraconazole.Leishmania martiniquensis is a cause of cutaneous leishmaniasis in Thailand.
Voluntary Medical Care Insurance in the United States
Authors: Lawson Wilkins
Journal: JAMA (1949)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Abstract 19411: Circulating Protein Z Levels, Variants in the Protein Z Gene and Unexplained Cerebral Infarction in Young and Middle-Aged Adults (The Thrombophilia in Cryptogenic stroke [THICK] Study)
Authors: Lili Zhang, Alan Z Segal, Roy L Silverstein, Linda M Gerber, Martin L Lesser, Richard B Devereux, Jorge R Kizer
Journal: Circulation (2014)

Background: Protein Z (PZ) is a vitamin K-dependent plasma protein that exhibits both pro- and anticoagulant properties. Both low and high PZ levels have been linked to ischemic stroke in different studies. PZ-lowering gene variants have in turn been found to be less common in ischemic stroke, suggesting that PZ deficiency may be protective, but the relationship remains unclear. Methods: We investigated PZ levels and PROZ gene variants in a prospective case-control study of prothrombotic risk factors for unexplained stroke in subjects ages 18 to 64. Cases consisted of patients referred to Weill Cornell Medical Center (2002 - 2012) for the first cerebral infarction whose etiology proved indeterminate (TOAST criteria). Controls included stroke-free volunteers from the area. Plasma PZ was measured in cases (≥2 months post-stroke) and controls. PZ polymorphisms G79A (rs3024735) and A13G (rs2273971) were genotyped. A combined genetic score (0-4) was created assuming additive effects. Results: A total of 679 su...
The Diagnostic Cascade of Incidental Findings
Authors: Linh T. Nguyen, Christopher T. Sullivan, Anil N. Makam
Journal: JAMA Internal Medicine (2015)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Internal Medicine HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Internal Medicine journal
Neural respiratory drive and arousal in patients with obstructive sleep apnea–hypopnea
Authors: Sichang Xiao, Yingxin Wu, Baiting He, Joerg Steier, John Moxham, Michael I. Polkey, Yuanming Luo
Journal: European Respiratory Journal (2014)

Background:  Repetitive arousals after apnea and hypopnea events in patients with obstructive sleep apnea have been hypothesized to be triggered by respiratory effort.   Objectives:  The purpose of the study is to determine whether the threshold of respiratory drive responsible for arousal for apnea is the same as that for hypopnea.   Methods:  Seventeen subjects (two females and fifteen males, mean age 53±11 years) with obstructive sleep apnea and hypopnea were studied by recording diaphragm EMG and esophageal pressure during overnight full polysomnography.   Results:  A total of 709 hyponea events and 986 apnea events were analyzed. There was wide variation in Pes at the end of both apnea and hypopnea events and the maximal Pes could be four times higher than the minimal Pes at the end of apnea within a subject. 15.5%±14.2% of hypopnea events and 9.5%±11.6% of apnea events during stage 2 were terminated without arousal. There was significant difference in EMGdi at the end of respiratory events between hypopnea and apnea [(25.3±14.2) % EMGmax. vs (21.7 ±13.2)%EMGmax, p 0.05)] and apnea events [(22.9±11.5) % EMGmax vs (22.1±12.6) % EMGmax, p>0.05].   Conclusions:  our data do not support the concept that there is threshold of respiratory drive which responsible for arousal to resume airflow.
Tazza and Cover: Allegory of Fortune
Authors: M. Therese Southgate
Journal: JAMA (1998)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Abstract P443: Move for Health: Pedometer Based Assessment for Physical Activity among Resident Physicians at a Busy New York City Hospital
Authors: Azhar A Supariwala, Shivkumar Agarwal, Poonam Pai, Swathi Sangli, Yathin Thammaiah, Manideep Duttuluri, Swathi Parvanetni, Sai Sreenija Dukkipati, Keerthana Paladugu, Randy Cohen, Seth Uretsky, Alan Rozanski
Journal: Circulation (2014)

Background: Regular physical activity (PA) improves mental health and decreases the incidence of coronary heart disease. Current guidelines recommend &gt;10,000 steps/day (s/d) as an appropriate PA target. We studied the self-perception of PA among the physicians and compared it with an objective measure using a pedometer. Methods: 85 internal medicine physicians,91% residents (age: 30±3.8 yrs; 57% Male) were enrolled in this study. Demographic and international physical activity questionnaire (IPAQ) were obtained. Participants were instructed to wear an Omron HJ-720 pedometer all day except during sleep to record average s/d over a 7 day period. The pedometer steps were not made visible to the participants. Physicians were stratified according to sedentary lifestyle [SL] (7500 s/d). Results: Mean daily steps were 6521 ± 2524 s/d. Only 8(9.4%) participants reached the recommended target of &gt;10,000 s/d. Mean daily steps at work (6AM to 5PM) were 4420±2242 s/d, which constituted 68% ± 24% of their daily PA. There were 26 (31%) subjects in the SL group (3551 ±1075 s/d), 27 (32%) LA group (6340 ± 819 s/d) and 32 (38%) in SA group (9086 ± 1243 s/d). Step count did not correlate with age, gender, BMI, foreign or American medical graduate, PGY status, or type of rotation (floors,ICU, electives). At the time of enrollment, 56% of physicians stated that they achieve “enough” PA. According to the IPAQ, 61% of physicians were in the high PA group. However, these PA levels did not correlate with objective pedometer measurements. SA group had higher work time PA (p&lt;0.001). All groups maintained the week day PA during the weekends. Conclusion: Despite the perception of being PA, most physicians in our study did not achieve the recommended daily steps/day. “Walking at work” is not enough to reach recommended PA targets. Future research is needed for successful strategies to create awareness and improve PA among physicians.
Responding to change
Authors: J. Bennett
Journal: BMJ (1997)

Job plans and team working are two ways in which consultants can manage the pressures that the changes of recent years have brought. The treasurer of the Royal College of Physicians, John Bennett, outlines the college's latest report 

What do you think about when someone suggests “structuring your career” or “planning for optimal performance in later years”? Don't tell me, your eyes glaze over as you contemplate the likelihood of getting through the next medical take, let alone the next 40 years.

That is precisely why the Royal College of Physicians recently took a long hard look at the way in which a medical career is structured, or more often not structured. Most doctors are far too busy to look at the issue in depth themselves so we decided we had to take this forward ourselves.

It has become increasingly obvious that the past five years at the coal face in the NHS have taken a heavier than usual toll on physicians, with committed doctors seemingly queuing up for early retirement at a time when stability above all things was needed. Many factors - loss of morale, increasing demands of patients, growth of managerial and administrative tasks, and the effects of Calman have made us realise what a pounding consultants have taken and ask whether we could do anything to make it better not worse.

When in doubt, set up a working party - but this time make it produce a no waffle, nitty gritty document that concentrates on the aspects of the work we do have control over - job plans, the set up of the medical team, and the issue of medical professionalism. Changes in all these areas that suit both physicians and their hospitals can help in long term planning of a career. More control will lead …
Abstract P392: Childhood Risk Factors and Adulthood Risk of Pregnancy-Induced Hypertension: The Bogalusa Heart Study
Authors: Shengxu Li, Xu Xiong, Camilo Fernandez, Wei Chen, Sathanur S Srinivasan, Gerald S Berenson
Journal: Circulation (2014)

Background: Hypertension in pregnancy is an important cause of both maternal and fetal morbidity and mortality. Whether hypertension in pregnancy has its risk factor(s) in childhood is not known. The objective of this study was to examine the association between childhood risk factors and hypertension in pregnancy later in life. Methods: A nested case-control analysis was performed based on the longitudinal Bogalusa Heart Study cohort (67% white and 33% black), with an average follow-up period of 26.2 years. Cases were defined as women who had hypertension during pregnancy and had normal blood pressure measurements after the pregnancy (n=82). Controls were defined as women with normal blood pressure without hypertension in pregnancy (n=454). Childhood risk factors included body mass index (BMI), systolic and diastolic blood pressure, high- and low-density lipoprotein cholesterols, and triglycerides. Univariable and multivariable logistic regression were used to estimate the odds ratio (OR) and 95% confidence interval (CI), with childhood risk factors standardized to age- and race-specific z-scores based on the total population of 5419 female subjects. Results: Cases and controls had comparable age in childhood (10.1 vs 9.8 years, P=0.53). Cases vs controls had higher BMI (19.1 vs 17.6 kg/m2, P&lt;0.001) and systolic blood pressure (101.8 vs 99.2 mm Hg, P=0.002) in childhood. In univariable analysis, significant childhood predictors for having hypertension in pregnancy included BMI (OR corresponding to 1 age- and race-specific standard deviation change =1.45, 95% CI: 1.15-1.83) and systolic blood pressure (1.48, 1.15-1.89). BMI and systolic blood pressure remained as significant predictors for having hypertension in pregnancy in multiple regression analysis (1.34, 1.03-1.75 and 1.33, 1.01-1.74, respectively). Conclusions: Childhood BMI and systolic blood pressure are significant predictors for having pregnancy-induced hypertension in adulthood, which underscores the importance of childhood risk factors assessment and early intervention.
Generic prescribing: time to regulate the market?
Authors: T Walley
Journal: BMJ (2000)

Successive governments have promoted the prescribing of drugs by generic rather than by proprietary name as a means of maintaining clinical quality while containing costs. The rate of generic prescribing is now 69%1 and is one of the measures used for assessing performance in primary care.2 The past year has seen a dramatic increase in the cost of generic medicines. As well as burdening the NHS with increased costs, these price rises threaten to undermine the development of primary care groups and suggest that the market for generic drugs can no longer remain unregulated.

Drugs prescribed generically may be dispensed as either a branded product (about 7%) or a lower cost non-branded one (62%). The price paid by the NHS to community pharmacists and dispensing doctors for most generically dispensed drugs is set out in the Drug Tariff 3 and based on prices charged by a range of suppliers. The market for generic medicines is not regulated, as it was thought that market forces would keep their prices down. In the past year there have been dramatic prices rises in many generic medicines and shortages of some important medicines, such as metformin. The reasons …
Coronary Angiography With Multislice Computed Tomography
Authors: Marc Dewey
Journal: JAMA (2005)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Tumor Microenvironment Remodeling by 4-Methylumbelliferone Boosts the Antitumor Effect of Combined Immunotherapy in Murine Colorectal Carcinoma
Authors: Mariana Malvicini, Esteban Fiore, Valentina Ghiaccio, Flavia Piccioni, Miguel Rizzo, Lucila Olmedo Bonadeo, Mariana García, Marcelo Rodríguez, Juan Bayo, Estanislao Peixoto, Catalina Atorrasagasti, Laura Alaniz, Jorge Aquino, Pablo Matar, Guillermo Mazzolini
Journal: Molecular Therapy (2015)

We have previously demonstrated that a low dose of cyclophosphamide (Cy) combined with gene therapy of interleukin-12 (AdIL-12) has a synergistic, although limited, antitumoral effect in mice with colorectal carcinoma. The main mechanism involved in the efficacy of Cy+AdIL-12 was the induction of a specific immune response mediated by cytotoxic T lymphocytes. Our current aims were to evaluate the effects of 4-methylumbelliferone (4Mu), a selective inhibitor of hyaluronan (HA) synthesis, on tumor microenvironment (TME) and to investigate how 4Mu affects the therapeutic efficacy of Cy+AdIL-12. The results showed that 4Mu significantly reduced the amount of tumoral HA leading to a significant decrease in tumor interstitial pressure (TIP). As a consequence, tumor perfusion was improved allowing an increased adenoviral transgene expression. In addition, treatment with 4Mu boosted the number of cytotoxic T lymphocytes that reach the tumor after adoptive transfer resulting in a potent inhibition of tumor growth. Importantly, we observed complete tumor regression in 75% of mice when 4Mu was administrated in combination with Cy+AdIL-12. The triple combination 4Mu+Cy+AdIL-12 also induced a shift toward antiangiogenic factors production in tumor milieu. Our results showed that TME remodeling is an interesting strategy to increase the efficacy of anticancer immunotherapies based on gene and/or cell therapy.
A Serum-Free Nutrient Solution Sustaining Rapid and Continuous Proliferation of Strain L (Earle) Mouse Cells&lt;xref ref-type="fn" rid="fn1"&gt;2&lt;/xref&gt;
Authors: Charity Waymouth
Journal: JNCI Journal of the National Cancer Institute (1956)

A Serum-Free Nutrient Solution Sustaining Rapid and Continuous Proliferation of Strain L (Earle) Mouse Cells Get access Charity Waymouth Charity Waymouth Roscoe B. Jackson Memorial Laboratory, Bar Harbor, Maine Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 17, Issue 3, September 1956, Pages 315–327, https://doi.org/10.1093/jnci/17.3.315 Published: 01 September 1956 Article history Received: 27 April 1956 Published: 01 September 1956
Abstract 16299: Rural-Urban Disparities in Emergency Medical Services Utilization for ST-Elevation Myocardial Infarction (STEMI)
Authors: Ross F Garberich, Rashmee Shah, David M Larson, Scott Sharkey, Jay H Traverse, Paul Sorajja, David Hildebrandt, Timothy D Henry
Journal: Circulation (2014)

Introduction: National guidelines recommend pre-hospital ambulance triage of ST-elevation myocardial infarction (STEMI) patients to PCI hospitals. Emergency medical services (EMS) continue to be underutilized. Methods: Using a comprehensive prospective regional STEMI program database, we evaluated demographic information and clinical outcomes of STEMI patients based on EMS utilization and the size of the community where the patient initially presented. Community sizes were defined as urban (PCI Center/Metropolitan core), small city (population 10,000 to 49,999), and rural (population < 10,000). Results: From March 2003 to August 2013, 3,854 consecutive STEMI patients presented to the tertiary PCI hospital within the regional STEMI system, including 960 (24.9%) admitted from the urban center, 1,737 (45.1%) transferred from a small city and 1,157 (30.0%) from a rural community. EMS utilization was significantly higher in the urban center compared to small and rural communities (Table 1). In all three commun...
Parkinson Disease Studies Yield Insights
Authors: M J Friedrich
Journal: JAMA (2005)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
465. Delivery of NF-κβ Decoy Related Oligodeoxynucleotides Reduces Pro-Inflammatory Cytokine Responses Associated with Plasmid DNA/Lipid Mediated Gene Transfer to Murine Lungs
Authors: Anusha Varathalingam, Ian A. Pringle, Seng H. Cheng, Deborah R. Gill, Stephen C. Hyde
Journal: Molecular Therapy (2004)