Studies on the Mechanism of the Pain of Peptic Ulcer
Authors: Fred M. Smith, W. D. Paul
Journal: Annals of Internal Medicine (1931)

Article1 July 1931Studies on the Mechanism of the Pain of Peptic UlcerFRED M. SMITH, M.D., F.A.C.P., W. D. PAUL, M.D.FRED M. SMITH, M.D., F.A.C.P.Search for more papers by this author, W. D. PAUL, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-5-1-14 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptVarious explanations have been given for the pain of peptic ulcer. In general, however, there are two prevailing conceptions. One is primarily concerned with the irritating action of the hydrochloric acid of the gastric juice on the exposed nerve endings in the ulcer. The other places the emphasis on the altered motor function as represented by spasm, particularly of the pylorus or pyloric sphincter, hyperperistalsis or a combination of these factors producing increased gastric tension.Talma1was one of the first to study the mechanism of gastric pain by the introduction of acid into the stomach. Bönninger,2Heinecke and von...References1 TALMA S: Zur Behandlung von Magenkrankheiten, Zeit. f. klin. Med., 1884, VIII, 407. Google Scholar2 BÖNNIGER M: Zur Diagnose des Ulcus Ventriculi, Berl. klin. Wchnschr., 1908, XLV, 396. Google Scholar3 HEINEKEVAN SELMS DM: De la sensibilité de l'estomac, Arch. des Mal. de l'Appar. dig., 1908, II, 467. Google Scholar4 SIPPY BW: Oxford Medicine, New York, Oxford Univ. Press, Vol. 3, Page 132. Google Scholar5 PALMER WL: The mechanism of pain in gastric and duodenal ulcer; production of pain by means of chemical irritants, Arch. Int. Med., 1926, XXXVIII, 694. CrossrefGoogle Scholar6 HURST AF: The sensibility of the alimentary canal, London, 1911. Google Scholar7 HURSTSTEWART AFMJ: Gastric and duodenal ulcer, New York, Oxford Univ. Press, 1929. Google Scholar8 RYLE JA: A clinical study of pain: with special reference to the pains of visceral disease, Brit. Med. Jour., 1928, I, 537. CrossrefGoogle Scholar9 CARLSON AJ: The control of hunger in health and disease, Chicago, 1906. Google Scholar10 GINSBURGTUMPOWSKYHAMBURGER HIWW: Newer interpretation of the gastric pain in chronic ulcer, J. A. M. A., 1916, LXVII, 990. CrossrefGoogle Scholar11 CARLSON AJ: Contributions to the physiology of the stomach, XLIV. The origin of the epigastric pains in cases of gastric and duodenal ulcer, Amer. Jour. Physiol., 1917, XLV, 81. CrossrefGoogle Scholar12 HARDT LL: Pain in active pathologic processes in stomach or duodenum; gastric and duodenal contractions as the direct cause. J. A. M. A., 1918, LXX, 837. CrossrefGoogle Scholar13 HARDT LL: Studies of the cause of pain in gastric and duodenal ulcers; peristalsis as direct cause of pain in gastric ulcers with achylia and in duodenal ulcers, Arch. Int. Med., 1922, XXIX, 684. CrossrefGoogle Scholar14 ORTMAYER M: Gastric motor activity in patients with peptic ulcer, Arch. Int. Med., 1925, XXXV, 423. CrossrefGoogle Scholar15 HOMANS J: The relation of pain in gastric and duodenal ulcer to muscular activity of the stomach, Amer. Jour. Med. Sci., 1919, CLVII, 74. CrossrefGoogle Scholar16 POULTON EP: An investigation of the cause and relief of pain in gastric ulcer, Lancet, 1921, CC, 263. CrossrefGoogle Scholar17 MACLEOD D: A note on pain in relation to duodenal ulcer, Lancet, 1929, CCXVII, 1358. CrossrefGoogle Scholar18 POULTON EP: On an experimental study of certain visceral sensations, Lancet, 1928, CCXV, 1223. Google Scholar19 REYNOLDSMCCLURE LCW: Motor phenomena occurring in normal stomachs, in presence of peptic ulcer and its pain, as observed fluoroscopically, Arch. Int. Med., 1922, XXIX, 1. CrossrefGoogle Scholar20 WILSONMALCOLM J: Duodenal ulcer: Observations on the behavior of stomach and duodenum in the presence of pain, Arch. Int. Med. 1928, XLI, 633. CrossrefGoogle Scholar21 SMITHPAULFOWLER FMWDWM: The mechanism of the epigastric distress associated with an irritable colon and chronic appendicitis, Arch. Int. Med. 1931, XLVII, 316. CrossrefGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Iowa City, Iowa*From the Department of Internal Medicine, State University of Iowa.†Delivered at the Baltimore Meeting of The American College of Physicians, March 23, 1931. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byPain in peptic ulcerMechanism of Pain in Peptic UlcerGrundlagen der gastrographischen MethodikThe value of a special pepsin-pancreatic preparation in the treatment of peptic ulcer and gastric hyperacidityPeptic Ulcer 1 July 1931Volume 5, Issue 1Page: 14-22KeywordsGastric ulcersHydrochloric acidNerve endingsPeptic ulcersStomach ePublished: 1 December 2008 Issue Published: 1 July 1931 PDF downloadLoading ...