tbuckley/cabot-search huggingface dataset:
Cyclooxygenase Inhibitors and Cardiovascular Risk
Authors: Frank Andersohn, Samy Suissa, Edeltraut Garbe
Journal: JAMA (2003)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Mortality Associated With Systemic Lupus Erythematosus in France Assessed by Multiple‐Cause‐of‐Death Analysis
Authors: Guillemette Thomas, Julien Mancini, Noémie Jourde‐Chiche, Gabrielle Sarlon, Zahir Amoura, Jean‐Robert Harlé, Eric Jougla, Laurent Chiche
Journal: Arthritis & Rheumatology (2014)

To assess the mortality profile of systemic lupus erythematosus (SLE) patients in France using multiple-cause-of-death analysis.Data were collected between 2000 and 2009 in the French Epidemiological Center for the Medical Causes of Death database, and death certificates issued upon the death of an adult for whom SLE was an underlying cause of death (UCD) or a non-underlying cause of death (NUCD) were evaluated using multiple-cause-of-death analysis. Sex, age, sex ratio, standardized mortality rates, as well as frequency of the various causes of death were assessed, at both a national and a regional level. For the main causes of death, the observed number of deaths in relation to the expected number of deaths (O:E ratio) (standardized for age and sex) was calculated.During the study period, 1,593 deaths related to SLE were identified. The mean ± SD age at death was 63.5 ± 18.4 years and the sex ratio (female:male) was 3.5. The mean standardized mortality rate was 3.2 per 1 million people (range 2.7-4.1). When SLE was the UCD (n = 637), the main NUCDs were cardiovascular diseases (49.5%), infectious diseases (24.5%), and renal failure (23.2%). When SLE was an NUCD (n = 956), the most common UCDs were cardiovascular diseases (35.7%), neoplasms (13.9%), and infectious diseases (10.3%). The overall O:E ratio was >1 for infectious and cardiovascular diseases and renal failure (especially among people <40 years of age for the latter 2 causes), but was <1 for neoplasms.Cardiovascular disease is the leading cause of death associated with SLE in France.
Treatable causes of sudden death: not really “treatable” or not really the cause?**Editorials published in the Journal of the American College of Cardiologyreflect the views of the authors and do not necessarily represent the views of JACCor the American College of Cardiology.
Authors: Sami Viskin, Amir Halkin, Jeffrey E. Olgin
Journal: Journal of the American College of Cardiology (2001)
NIH Director Elias A. Zerhouni, MD, Reflects on Agency's Challenges, Priorities
Authors: Catherine D. DeAngelis
Journal: JAMA (2003)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
SUBACUTE BACTERIAL ENDOCARDITIS, STREPTOCOCCUS VIRIDANS, WITH MESENTERIC THROMBOSIS AND RECOVERY
Authors: M I LOWANCE, E C JONES
Journal: Annals of Internal Medicine (1946)

Excerpt CASE REPORT Present Illlness. The patient was a 25 year old white male, admitted to the hospital June 19, 1944, with a history of illness for the preceding five to six months. He stated tha...
Abstract 7: Vasopressin and Restrictive Fluid Resuscitation Improves Survival from Hemorrhagic Shock After Liver Laceration in Swine
Authors: Herbert K Whitehouse, Alvin Baetiong, Jeejabai Radhakrishnan, Raúl J Gazmuri
Journal: Circulation (2014)

Background: Previous studies in swine models of hemorrhagic shock (HS) designed by us to assess interventions that could be applied in the battlefield showed that vasopressin (VP) infusion promotes hemodynamic stability and markedly improves survival. In these studies, however, blood was removed through a cannula lacking the tissue injury and uncontrolled nature of trauma-associated HS. We report here the effects of VP infusion and restrictive fluid resuscitation during HS in a model of liver laceration (LL) that incorporates the effects of uncontrolled bleeding and tissue injury. Methods: Forty male domestic pigs (32.3 to 40.3 kg) had the left lateral liver lobe lacerated using a sharpened steel, X-shaped 5 cm blade clamp, resembling a gunshot wound. Thirty-two animals received a second LL in the same lobe 7.5 minutes later and 24 animals received a third LL in the left medial lobe at 15 minutes from the first LL. Animals were randomized 1:1:1:1 to receive VP, normal saline (NS), VP and NS, or neither VP...
Recombinational DNA double-strand breaks in mice precede synapsis
Authors: Shantha K. Mahadevaiah, James M.A. Turner, Frédéric Baudat, Emmy P. Rogakou, Peter de Boer, Josefa Blanco-Rodríguez, Maria Jasin, Scott Keeney, William M. Bonner, Paul S. Burgoyne
Journal: Nature Genetics (2001)
Polymer Injection Therapy to Reverse Remodel the Papillary Muscles: Efficacy in Reducing Mitral Regurgitation in a Chronic Ischemic Model
Authors: Jorge Solis-Martin
Journal: Circulation (2008)

Abstract 1104 Jorge Solis-Martin, Benjamin Johnson, J.Luis Guerrero, Mark Handschumacher, Suzanne Sullivan, Massachusetts General Hosp, Boston, MA; G.J.C Braithwaite, Cambridge Polymer, INC, Boston, MA; O.k. Muratoglu, G.j Vlahakes, Robert A Levine, Judy Hung, Massachusetts General Hosp, Boston, MA Jorge Solis-Martin, 2008 Finalist and Presenting Author
Abstract 15314: Differential Association of Polymorphic Genetic Variants With Non-Pulmonary Vein Triggers in Patients With Non-Paroxysmal Atrial Fibrillation: Results From a Prospective Study (DECAF)
Authors: Sanghamitra Mohanty, Amelia W Hall, Prasant Mohanty, Chintan Trivedi, Luigi Di Biase, Rong Bai, Amin Al-Ahmad, Rodney Horton, John D Burkhardt, Javier Sanchez, Jason Zagrodzky, Shane Bailey, Joseph G Gallinghouse, Patrick Hranitzky, Vishwanath R Iyer, Andrea Natale
Journal: Circulation (2014)

Introduction: Earlier evidences support the origin of ectopic beats from non-pulmonary vein (non-PV) areas that initiate and maintain AF and elimination of these triggers is known to provide better arrhythmia-free survival. Of the different types, non-paroxysmal AF (NPAF) are more prevalently associated with non-PV drivers. Although emerging data on myocytes-fibroblast interactions provide some insight into the pathophysiology of non-PV triggers, the exact mechanism of origin of these ectopic foci is still unknown. Therefore, we examined the association of several AF-specific genetic variants with prevalence of non-PV triggers in NPAF patients undergoing catheter ablation. Methods: Four hundred AF patients (67% male, 62±12 year, left atrial size 45.3±7 mm, 64% non-paroxysmal) undergoing catheter ablation were prospectively enrolled at our center. DNA extraction and genotyping for 16 AF-associated SNPS from collected blood samples were performed using Qiagen QiaAMP 96 well blood kit and TaqMan assay respectively. Three hundred seventy-two DNA samples were available for genotyping. Multivariate logistic regression analysis (adjusted covariates: age, gender, LA size, hypertension and diabetes) was used for assessing predictive role of individual SNP; and logistic kernel-machine approach was applied to test the cumulative effect of multiple SNPs as a group with non-PV triggers. Result: In the non-paroxysmal AF population, significant allelic association was detected between non-PV triggers and rs6599230 (OR 0.57 [95% CI 0.31-0.88], p=0.042) and rs1448817 (OR 1.82 [95%CI 1.12-3.40], p=0.034). Interestingly, rs6599230 suggested a protective effect with 43% risk reduction while rs1448817 was an independent predictor of higher risk of developing non-PV triggers. Conclusion: Our results identified predictive association of two genetic variants, rs6599230 and rs1448817, with non-PV triggers in non-paroxysmal AF patients. Interestingly, the association was distinctive. The SNP, rs6599230 located in close proximity to SCN5A gene, was found to have a protective effect against development of arrhythmogenic triggers in the extra-PV sites whereas rs1448817 on chromosome 4q25 increased the risks of having non-PV triggers.
Abstract LB-298: The multiple-myeloma associated snoRNA, ACA11 increases oxidative stress and cell proliferation
Authors: Nitin Mahajan, Leonard B. Maggi, Michael H. Tomasson, Jason D. Weber
Journal: Cancer Research (2015)

Abstract Multiple myeloma (MM) is an incurable malignancy of antibody secreting plasma B cells. The t(4;14) translocation is detected in 20% of MM and is associated with shortened patient survival. Although the t(4;14) is known to up regulate the MMSET proteins, its role in MM remains unclear. Previously, we identified a novel orphan box H/ACA class small nucleolar RNA (snoRNA), that is located within intron 19 of MMSET, and is expressed in MM cells harboring the t(4;14) translocation. H/ACA small RNAs are an evolutionarily conserved class of abundant noncoding RNAs (ncRNA) involved in a diverse range of processes including posttranslational modifications of functional RNAs, preribosomal RNA processing, and telomere maintenance, yet their contribution to human disease remains largely unexplored. In this study, t(4:14) positive and negative MM patient tumor cells were analyzed by RNA sequencing. This revealed a unique signature of up regulated genes involved in mitochondrial respiration and oxidative stress. Our hypothesis is ACA11 plays critical role in MM cell proliferation and cell transformation by increasing oxidative stress. We found that acute ACA11 overexpression leads to the increased oxidative stress in primary splenic B-cells, established myeloma cell lines, as well as embryonic fibroblasts. In particular, cells overexpressing ACA11 showed enhanced proliferation, significantly larger colony sizes in soft agar assays, and elevated ERK1/2 phosphorylation, a downstream consequence of oxidative stress. In addition, we found that the transcription factor nuclear factor erythroid-derived 2-related factor 2 (Nrf2), which regulates anti-oxidant signaling, dissociated from Keap1 and translocated to the nucleus, but failed to activate anti-oxidant downstream targets in ACA11 overexpressing cells. Furthermore, ACA11 up regulated TXNIP, which encodes an inhibitor of ROS scavenger thioredoxin. In conclusion, we propose that acute overexpression of ACA11 up regulates TXNIP and suppresses the ability of Nrf2 to induce target anti-oxidants genes, resulting in increased oxidative stress and cell proliferation. These changes may be critical events in the development and/or progression of multiple myeloma. Citation Format: Nitin Mahajan, Leonard B. Maggi, Michael H. Tomasson, Jason D. Weber. The multiple-myeloma associated snoRNA, ACA11 increases oxidative stress and cell proliferation. [abstract]. In: Proceedings of the 106th Annual Meeting of the American Association for Cancer Research; 2015 Apr 18-22; Philadelphia, PA. Philadelphia (PA): AACR; Cancer Res 2015;75(15 Suppl):Abstract nr LB-298. doi:10.1158/1538-7445.AM2015-LB-298
Botzaris Surprises the Turkish Camp and Falls Fatally Wounded
Authors: M. Therese Southgate
Journal: JAMA (2001)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Selected Topics on Genital Anomalies and Related Subjects.
Authors: M. Nabil Rashad, W. R. M. Morton
Journal: Annals of Internal Medicine (1970)

This volume is the third in a series designed to present scientific developments of clinical importance to the  practitioner and general scholar. Comprised of ten chapters of varied profundity, sophistication, and clinical utility, the book covers clinical interview, neuro-ophthalmologic examination, cerebrospinal fluid, brain biopsy, echoencephalography, and several roentgenographic topics. Nearly two thirds the book is devoted to the latter two. Janeway's description of aortocranial angiography provides lucid and complete instructions for those interested in undertaking this procedure. It might have emphasized some of the medical conditions necessary to assure the patient's safety (eg, the integrity of the clotting mechanism). The review of cerebral isotope scanning by Maynard and Janeway is informative and comprehensive. A rather general chapter devoted to ordering x-ray films can hardly be regarded as directed to the neurological practitioner. It might have been more useful had clinical examples been cited and illustrative flow sheets designed to guide the choice of roentgenographic study, beginning with plain films and pro¬ ceeding through contrast studies. The applicability of each special procedure, the precautions to be tak¬
Abstract 561: A natural copy number variant in the GAEC1 oncogene is associated with breast cancer susceptibility
Authors: Vinod Gopalan, Robert A. Smith, Suja Pillai, Lyn R. Griffiths, Alfred K-Y Lam
Journal: Cancer Research (2014)

Abstract The recently discovered GAEC1 oncogene, located at 7q22, has been found to be amplified in esophageal and colorectal cancers and is associated with altered clinical characteristics in those diseases. Amplification studies in these cancers showed variation in copy number in normal tissues, indicating a potential natural copy number variant (CNV) of GAEC1. In this research, the presence of such a CNV and its association with sporadic breast cancer development was tested in a population of 190 Caucasian women with breast cancer and a population of age, sex and ethnicity matched controls. Data produced by qPCR confirmed the presence of a CNV for GAEC1 in both cancer and control populations, with three common copy number types and several uncommon values, representing up to a 64-fold difference in GAEC1 copies. In addition, Chi-square analysis of copy number types indicated that increased GAEC1 copy number is associated with cancer development. This includes analysis using only the common copy number types (p=0.05) as well as considering all genotypes on a High/Low gene dosage basis (p=0.03). Overall risk for breast cancer was found to be slightly increased in high dose individuals (OR 1.552 (95% CI 1.035-2.338)). These results indicate that GAEC1 may be an important gene in the development of breast cancer, and that examination of its copy number in patient DNA may be a useful addition to genetic risk markers in sporadic cases. Citation Format: Vinod Gopalan, Robert A. Smith, Suja Pillai, Lyn R. Griffiths, Alfred K-Y Lam. A natural copy number variant in the GAEC1 oncogene is associated with breast cancer susceptibility. [abstract]. In: Proceedings of the 105th Annual Meeting of the American Association for Cancer Research; 2014 Apr 5-9; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2014;74(19 Suppl):Abstract nr 561. doi:10.1158/1538-7445.AM2014-561
Hours, sleep, teamwork, and stress
Authors: J. Firth-Cozens, F. Moss
Journal: BMJ (1998)

For every complex problem there is a simple solution … and it's wrong H L Mencken    

Many studies show that the quality of patient care can be severely affected by the stress levels of clinical staff, particularly doctors.1 We know too that doctors suffer high levels of stress and depression,2 more so than other workers.3 Strategies aimed at resolving the working difficulties of British doctors in training have been concerned primarily with the long, often excessive, hours worked. Following tough central directives and hard work by local task forces, many doctors now work fewer hours than five years ago. Has this reduced stress levels—or is there more to be done?

Hours of work are easy to measure and as a strategy of stress reduction reducing them has an attractive logic. However, very little evidence confirms a relation between the number of hours worked and the level of stress or depression experienced.1 Moreover, other factors cause junior doctors greater stress than hours alone—for example, difficult relationships with senior doctors.4 Not surprisingly therefore recent studies show stress levels to be …
Abstract 13219: Prognostic Value of Direct Bilirubin in Acute Decompensated Heart Failure
Authors: Atsushi Okada, Yasuo Sugano, Toshiyuki Nagai, Takafumi Yamane, Tatsuhiro Shibata, Kenji Nakamura, Naotsugu Iwakami, Daigo Chinen, Yasuhide Asaumi, Takeshi Aiba, Teruo Noguchi, Masaharu Ishihara, Kengo Kusano, Hisao Ogawa, Satoshi Yasuda, Toshihisa Anzai
Journal: Circulation (2014)

Background:  Where total bilirubin is known as a strong prognostic predictor in chronic heart failure, prognostic role of bilirubin fractionation in acute decompensated heart failure (ADHF) is unknown. Increased serum direct bilirubin (DB) is known to occur by cholestasis or acute liver injury. The present study was conducted to investigate the impact of bilirubin fractionation on mortality in patients with ADHF from the prospective registry of our institution.   Method:  We studied 307 consecutive patients admitted for ADHF from January 2013 to January 2014. All patients had initial bilirubin values available, taken within 24 hours from admission. Patients’ basic characteristics data including sex, age, past medical history, medications, blood tests, and echocardiography were analyzed. Additionally, hemodynamic parameters in 37 patients who underwent initial right heart catheterization were analyzed. All-cause mortality was set as a primary endpoint in this study.   Results:  Of the 307 patients (75.5±12.0 years, 197 male), 21 patients (7%) died during a mean follow up period of 231 days. There were no significant differences in age, sex, use of ACEI/ARB/beta-blockers between patients with adverse event and those without. DB level was significantly higher in the event group (0.5±0.3 vs. 0.3±0.3 IU/l, p=0.02). Kaplan-Meier survival curves demonstrated that abnormal DB level of >0.4 IU/L was associated with significantly poorer clinical outcome in ADHF patients (p=0.007), whereas abnormal indirect bilirubin level of >0.8IU/L was not (p=0.74). Cox proportional hazards regression analysis showed that DB level is an independent predictor of all-cause mortality (HR=24.6, p=0.04) among variables including age, sex, serum Na concentration, plasma BNP, and left ventricular ejection fraction. In addition, patients with elevated DB had higher central venous pressure (16±10 vs. 7±5mmHg, p=0.001) and tended to have lower cardiac index (1.8±0.7 vs. 2.2±0.7 L/min/m2, p=0.12).   Conclusion:  Abnormal DB level is a novel and powerful predictor of all-cause mortality in ADHF. Systemic venous congestion due to right heart failure may cause cholestasis and acute liver injury, resulting in elevation of serum DB level.
Panorama of Eight Views of Kanazawa Under the Full Moon
Authors: M. Therese Southgate
Journal: JAMA (1999)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal