tbuckley/cabot-search huggingface dataset:
Depressed function of a ouabain-sensitive sodium-potassium pump in blood vessels from renal hypertensive dogs.
Authors: H W Overbeck, M B Pamnani, T Akera, T M Brody, F J Haddy
Journal: Circulation Research (1976)

Vasodilator responses to acute intra-arterial infusions of K+ are attenuated in dogs with chronic one-kidney perinephritic hypertension in rats with chronic two-kidney Goldblatt hypertension, and in men with essential hypertension. There is evidence that K+ evokes vasodilation by stimulating vascular smooth muscle membrane Na+-K+-activated adenosine triphosphatase, thereby increasing activity of the cellular Na+-K+ electrogenic pump. We therefore proposed that there may be an underlying decrease in the operation of this pump in vascular smooth muscle of hypertensives. The operation of the cellular Na+-K+ pump may be estimated by measurement of rubidium uptake. Thus, so further investigate our hypothesis, we measured 86Rb uptake in small mesenteric arteries and splanchnic veins from 12 dogs with chronic uncomplicated one-kidney perinephritic hypertension and from 12 normotensive control dogs. Vessels were excised under thiamylal anesthesia and incubated in cold medium (plasma or Krebs-Henseleit solution) for sodium loading and then the velocity of 86Rb uptake was estimated in the absence of or in the presence of ouabain, a specific inhibitor of the Na+-K+ pump. In neither arteries nor veins was there evidence for differences between hypertensives and normotensives in the ouabain-insensitive uptake of 86Rb. In contrast, the ouabain-sensitive 86Rb uptake was depressed by 42% in arteries (P less than 0.05) and by 49% in veins (P less than 0.01) from hypertensive dogs, if incubated in the dog's own plasma. These results indicate that the activity of a ouabain-sensitive Na+-K+ pump may be depressed in vascular tissue from dogs with chronic one-kidney perinephritic hypertension. Because the Na+-K+ pump in vascular smooth muscle is probably electrogenic, such an abnormality, by partially depolarizing the muscle cell membrane, would help to account for the elevated vascular resistance found in these dogs.
Malassezia sympodialis thioredoxin–specific T cells are highly cross-reactive to human thioredoxin in atopic dermatitis
Authors: Hari Balaji, Annice Heratizadeh, Katja Wichmann, Margarete Niebuhr, Reto Crameri, Annika Scheynius, Thomas Werfel
Journal: Journal of Allergy and Clinical Immunology (2011)
Sports doctors' resuscitation skills
Authors: Paul Schur
Journal: British Journal of Sports Medicine (2001)

Sports doctors' resuscitation skillsEDITOR,-I cannot resist the temptation to join the debate on sports doctors' resuscitation skills. 1 2 The study by Thompson et al 3 suggested that there is a perceived need among sports specialists for first aid skills.However, I received no response to my letter concerning this 4 which indirectly posed the question, "should doctors who attend aquatic sports be able to deal with a suspected cervical spine fracture and recover the casualty?"Obviously, that is the task of a lifeguard in the same way that first aid at non-aquatic events is the task for a first aider, but perhaps doctors should be competent first aiders and/or lifeguards.This was never in the medical school curriculum and perhaps that should change.At least, first aid training is part of sports medicine courses, but I would like to suggest that lifeguarding should also be included.I would also suggest that all doctors at aquatic events should hold the NPLQ, NBLQ, or at least bronze medallion and bronze cross of the RLSS or overseas equivalent.Should the organisers of any sports medicine course want advice on this, they should contact the RLSS at River House, High St, Broom, Alcester, Warwickshire B50 4HN, UK.I would be happy to help out but would make two stipulations: everyone on the course should feel obliged to join the RLSS and they should sponsor me for my next fund raising event for the RNLI.
Quantitative Leukocyte Iodination
Authors: Stephanie H. Pincus, Seymour J. Klebanoff
Journal: New England Journal of Medicine (1971)

Abstract The conversion of iodide to a trichloroacetic-acid-precipitable form by phagocytizing human leukocytes was employed as the basis for a quantitative leukocyte iodination test, lodination was markedly reduced in the leukocytes of three male patients with chronic granulomatous disease, one female patient with familial lipochrome histiocytosis, and one male patient with myeloperoxidase deficiency. Leukocytes from three mothers of male patients with chronic granulomatous disease had moderately decreased iodination, whereas those from two female patients with the syndrome of recurrent cold staphylococcal abscesses had normal iodination. Iodination by leukocytes from patients with chronic granulomatous disease or familial lipochrome histiocytosis was increased by the substitution of live for heat-killed hydrogen-peroxide-generating organisms as the ingested particles. The quantitative iodination test correlates to some degree with microbicidal activity, and is therefore recommended as a simple, useful p...
BIPOLAR RADIOFREQUENCY SURGICAL MAZE-ABLATION OF THE LEFT ATRIUM EFFECTIVELY TREATS PERSISTENT ATRIAL FIBRILLATION BUT DECREASES LEFT ATRIAL FUNCTION
Authors: Marieke Compier, Jerry Braun, Victoria Delgado, Katja Zeppenfeld, Robert Klautz, S.A.I.P. Trines, Martin Schalij
Journal: Journal of the American College of Cardiology (2012)
Effort Launched to Adapt HIV/AIDS Drugs for Children
Authors: Rebecca Voelker
Journal: JAMA (2011)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Human myofibroblastic hepatic stellate cells express Ca2+-activated K+ channels that modulate the effects of endothelin-1 and nitric oxide
Authors: Xavier Gasull, Ramón Bataller, Pere Ginès, Pau Sancho-Bru, Josep Marı́a Nicolás, Marı́a Nieves Görbig, Elisa Ferrer, Eva Badı́a, Arcadi Gual, Vicente Arroyo, Juan Rodés
Journal: Journal of Hepatology (2001)
Effects of Nifedipine in Achalasia and Patients With High-Amplitude Peristaltic Esophageal Contractions
Authors: Francisco J. Román
Journal: JAMA (1985)

To the Editor.—  In the Oct 5 issue ofThe Journal, Traube et al 1 reported the effects of nifedipine on esophageal motility in achalasia and in nutcracker esophagus. A decrease in lower esophageal sphincter (LES) pressure was noted in both disorders. However, nifedipine also decreased contraction amplitude of the esophageal body in nutcracker esophagus, but not in achalasia.  We have recently evaluated 14 patients with classic achalasia before and after the administration of nifedipine (20 mg, sublingually). We observed a decrease in LES pressure (basal pressure, 26.5 ±8.7 mm Hg) of 16%, 35%, and 40% at 15, 30, and 45 minutes, respectively, after the administration of the drug. There were no significant changes in contraction amplitude in the body of the esophagus. These observations are similar to those reported by Traube et al.  Why did nifedipine decrease the body contractions in nutcracker esophagus but not in achalasia? In achalasia,
Arterial stiffness and left ventricular geometry and function in hypertensive patients with electrocardiographic left ventricular hypertrophy: the LIFE study
Authors: Vittorio Palmieri, Jonathan N. Bella, Mary J. Roman, Eva Gerdts, Vasilios Papademetriou, Kristian Wachtell, Markku S. Nieminen, Björn Dahlöf, Richard B. Devereux
Journal: Journal of the American College of Cardiology (2002)
776-4 Intact cNOS-NO-cGMP Pathway in the Failing Human Heart
Authors: Chi-Ming Wei, John Lust, Zvonimir Katusic, Michihisa Jougasaki, Denise Heublein, Sharon Sandberg, Debra Lewis, Virginia Miller, Christopher McGregor, John Burnett
Journal: Journal of the American College of Cardiology (1995)
Evidence for sodium-dependent hypoxanthine uptake in isolated guinea pig ventricular myocytes: stimulation by extracellular Ni2+
Authors: P. S. Haddock
Journal: Cardiovascular Research (1995)

Concentrative transport systems for nucleobases have been identified in renal epithelial cells and jejunal tissue rings. However, the existence and role of nucleobase transport has yet to be described in the heart. The aims of this study were, therefore, to use isolated guinea pig myocytes to: (i) identify whether such a mechanism is present in the heart and (ii) characterise and compare its activity to that already described in other tissues.The Na(+)-dependent and Na(+)-independent uptake of [3H]hypoxanthine was quantified in ventricular myocytes. These were isolated from the hearts of adult guinea pigs using a collagenase-based enzymatic digestion technique. The specific incorporation of cellular radioactivity, in the presence and absence of extracellular sodium and other pharmacological agents, was determined by liquid scintillation counting.A system that accumulates hypoxanthine against a concentration gradient in the presence of extracellular sodium was identified. Furthermore, a sodium-independent component of hypoxanthine uptake was also characterised, a proportion (approximately 50%) of which was inhibited by adenine (3 mmol/l). In the absence of sodium and the presence of adenine, the remaining fraction of hypoxanthine uptake was assumed to occur via diffusion. The sodium-dependent uptake of hypoxanthine was saturable at 25 degrees C with a Km of 8.1 +/- 2.1 mumol/l and a Vmax of 50.1 +/- 5.2 pmol/mg protein/min. Dipyridamole inhibited sodium-dependent uptake but had no effect on sodium-independent flux. The Na(+)-independent system was saturable with a Km of 157.3 +/- 6.2 mumol/l and a Vmax of 233.6 +/- 5.6 pmol/mg protein/min. Extracellular Ni2+ stimulated sodium-dependent uptake in a concentration-dependent manner (0-100 mEq/l). Another divalent cation (Ba2+, 100 mEq/l) had no effect on the either Na(+)-dependent or the Na(+)-independent component.These data provide the first evidence for sodium-dependent nucleobase co-transport in guinea pig myocytes. The sensitivity of this transporter to Ni2+ has not been described previously and may provide a pharmacological tool to study this uptake mechanism further.
PIK3CA and KRAS mutations predict for response to everolimus therapy: now that’s RAD001
Authors: Morassa Mohseni, Ben Ho Park
Journal: Journal of Clinical Investigation (2010)

Targeted cancer therapeutics can be effective when patients are preselected to maximize the chance of response. Increasingly, molecular markers such as oncogenic DNA mutations are being exploited to help guide patient preselection. These DNA lesions can predict for either a positive or negative response to a given drug. Finding such predictive biomarkers is an ongoing challenge. New work by Di Nicolantonio and colleagues in this issue of the JCI demonstrates that PI3K catalytic alpha subunit (PIK3CA) mutations can sensitize cancer cells to the mammalian target of rapamycin (mTOR) inhibitor everolimus. In addition, they show that the concurrent presence of PIK3CA mutations and mutations in either KRAS or BRAF predict for resistance to this drug. These data suggest that mTOR inhibitors currently in use will be ineffective against cancers that have a mutation in either KRAS or BRAF despite having PI3K/AKT/mTOR pathway activation.
Testing with Antineutrophil Cytoplasmic Antibody To Diagnose Wegener Granulomatosis
Authors: Stephen D.H. Malnick
Journal: Annals of Internal Medicine (1996)

Letters1 October 1996Testing with Antineutrophil Cytoplasmic Antibody To Diagnose Wegener GranulomatosisStephen D.H. Malnick, MA, MSc, MBBS, Ella Evron, MD, and Zev M. Sthoeger, MDStephen D.H. Malnick, MA, MSc, MBBSKaplan Hospital, Rehovot 76100, IsraelSearch for more papers by this author, Ella Evron, MDKaplan Hospital, Rehovot 76100, IsraelSearch for more papers by this author, and Zev M. Sthoeger, MDKaplan Hospital, Rehovot 76100, IsraelSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-125-7-199610010-00019 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:The recent paper by Rao and colleagues [1] was most interesting. We wish to explain the low positive predictive value of 63% for a positive c-ANCA test that the authors noted.Approximately 2% of the world's population is estimated to have chronic hepatitis C virus (HCV) infection [2]. It is now apparent that several extrahepatic manifestations are linked to chronic HCV disease [3]. These include vasculitis and cryoglobulinemia, which may cause symptoms similar to those of Wegener granulomatosis. We recently found a high (43.8%) incidence of c-ANCA in a cohort of patients with chronic HCV disease [4] ...References1. Rao JK, Weinberger M, Oddone EZ, Allen NB, Landsman P, Feussner JR. The role of antineutrophil cytoplasmic antibody (c-ANCA) testing in the diagnosis of Wegener granulomatosis. A literature review and meta-analysis. Ann Intern Med. 1995; 123:925-32. Google Scholar2. Davis GL. Hepatitis C virus. In: Mandell GL, Douglas RG, Bennet JE, eds. Principles and Practice of Infectious Diseases: Update 10. New York: Churchill Livingstone; 1991:3-11. Google Scholar3. Gumber SC, Chopra S. Hepatitis C: a multifaceted disease. Review of extrahepatic manifestations. Ann Intern Med. 1995; 123:615-20. Google Scholar4. Malnick SD, Lurie Y, Fogel N, Cohen P, Geltner D, Bass DD, et al. Chronic HCV hepatitis is associated with a high incidence of anti-neutrophil cytoplasmic antibodies and anti-cardiolipin antibodies [Abstract]. Hepatology. 1995; 22:352A. Google Scholar Author, Article, and Disclosure InformationAuthors: Stephen D.H. Malnick, MA, MSc, MBBS; Ella Evron, MD; Zev M. Sthoeger, MDAffiliations: Kaplan Hospital, Rehovot 76100, Israel PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byCase 28-1998 1 October 1996Volume 125, Issue 7Page: 622KeywordsChronic hepatitis CChronic liver diseaseHospitalsInfectious hepatitisLiverPositive predictive valueVasculitisWegener granulomatosis ePublished: 15 August 2000 Issue Published: 1 October 1996 Copyright & PermissionsCopyright © 1996 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
SURVEY OF THE PHYSICAL CONDITION OF CHILDREN BETWEEN THE AGES OF THREE AND FIVE YEARS IN CARDIFF AND RHONDDA SCHOOLS: WITH SPECIAL REFERENCE TO THE FACTOR OF MALNUTRITION
Authors: A. G. Watkins
Journal: BMJ (1935)

This investigation was an attempt to examine school children in the Cardiff and Rhondda areas, under 5 years of age, with the idea of gauging their physical condition and of determining what effects (if any) malnutrition and life in a " distressed area " may have upon their health.As no inquiry of this nature had been made in these areas it was felt that an investigation following the lines of that done by Spence' in the Newcastle-on-Tyne area would be of valu-e.Spence examined two main groups of childr-en between 1 anld 5 years old, and termed them the " city children " and the " professional families class," using the latter as a control group.In the present inquiry groups have been taken from elementary schools in two different areas.The need for a control group was urgently felt, but in spite of every effort it was not found possible to secure for examination an adequate number of children between the ages of 3 and 5 years in Cardiff living under good conditions in the residential part of the city.The difficulty of obtaining such a control group is stressed, because I feel that with it the results would have been correspondingly more valuable.It has, however, been possible to contrast the findings in Cardiff and the Rhondda.The two areas differ socially and geographically.Cardiff, in the main, is a cosmo- politan city with a varied iandustrial life, while the Rhondda is mainly confined to the coal industry, and because of its high unemployment rate comes under the official designation of a "distressed area."Geographically Cardiff is flat and enervating; the Rhondda is hilly, and above the level of the houses is open hillside with bracing air.
Cloning of the American cockroach Cr-PII allergens: Evidence for the existence of cross-reactive allergens between species☆☆☆★★★
Authors: Chii-Huei Wu, Nancy M. Wang, Mey-Fann Lee, Chiou-Yiing Kao, Shue-Fen Luo
Journal: Journal of Allergy and Clinical Immunology (1998)
Water Manganese Exposure and Children’s Intellectual Function in Araihazar, Bangladesh
Authors: Gail A. Wasserman, Xinhua Liu, Faruque Parvez, Habibul Ahsan, Diane Levy, Pam Factor-Litvak, Jennie Kline, Alexander van Geen, Vesna Slavkovich, Nancy J. LoIacono, Zhongqi Cheng, Yan Zheng, Joseph H. Graziano
Journal: Environmental Health Perspectives (2005)

Exposure to manganese via inhalation has long been known to elicit neurotoxicity in adults, but little is known about possible consequences of exposure via drinking water. In this study, we report results of a cross-sectional investigation of intellectual function in 142 10-year-old children in Araihazar, Bangladesh, who had been consuming tube-well water with an average concentration of 793 μg Mn/L and 3 μg arsenic/L. Children and mothers came to our field clinic, where children received a medical examination in which weight, height, and head circumference were measured. Children's intellectual function was assessed on tests drawn from the Wechsler Intelligence Scale for Children, version III, by summing weighted items across domains to create Verbal, Performance, and Full-Scale raw scores. Children provided urine specimens for measuring urinary As and creatinine and were asked to provide blood samples for measuring blood lead, As, Mn, and hemoglobin concentrations. After adjustment for sociodemographic covariates, water Mn was associated with reduced Full-Scale, Performance, and Verbal raw scores, in a dose–response fashion; the low level of As in water had no effect. In the United States, roughly 6% of domestic household wells have Mn concentrations that exceed 300 μg Mn/L, the current U.S. Environmental Protection Agency lifetime health advisory level. We conclude that in both Bangladesh and the United States, some children are at risk for Mn-induced neurotoxicity.
Commentaries on the IK1 blockade controversy (March Issue) From D Escande
Authors: D. Escande
Journal: Cardiovascular Research (1994)

Commentaries on the IK1 blockade controversy (March Issue) From D Escande Get access Denis Escande Denis Escande Laboratoire de Physiologie Cellulaire, URA CNRS 112 I, UniversitC Paris XI-Orsay, France. Search for other works by this author on: Oxford Academic PubMed Google Scholar Cardiovascular Research, Volume 28, Issue 7, July 1994, Pages 1117–1118, https://doi.org/10.1093/cvr/28.7.1118a Published: 01 July 1994
A doctor in the Great War--an interview with Sir Geoffrey Marshall.
Authors: G Marshall
Journal: BMJ (1982)

this year Sir Geoffrey Marshall was the oldest surviving physician at Guy's Hospital, where he qualified in 1911.He was born in 1887 on 23 April, St George's Day.Not that he cared much for St George, who, as he told me on his 89th birthday, was, according to Gibbon, a corrupt butcher who supplied poor-quality
Organoaxial Gastric Volvulus Detected by Meckel Scan
Authors: GEORGE BURKE, MARIA GISELA MERCADO-DEANE, EDWARD M. BURTON
Journal: Clinical Nuclear Medicine (1994)

A case of chronic gastric organoaxial volvulus, gastroesophageal reflux, esophagitis, and chronic anemia is presented. Reflux esophagitis and chronic anemia have not been reported previously as clinical signs associated with gastric volvulus in a child. A Meckel's scan is used to diagnose the displaced stomach.
Correction: An Error in a UCLA Conference on Immune Interventions
Authors: BRIAN R. SMITH
Journal: Annals of Internal Medicine (1987)

Letters and Corrections1 May 1987Correction: An Error in a UCLA Conference on Immune InterventionsBRIAN R. SMITH, M.D.BRIAN R. SMITH, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-106-5-783_2 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: A typographical error occurred in the article, "Immune Interventions in Disease," the UCLA Conference moderated by Dr. John Fahey (1). In Table 3, our data from a clinical trial of ex-vivo bone marrow T-cell depletion using an anti-CD5 monoclonal antibody and complement to abrogate graft versus host disease is presented. The data was taken from an abstract on the differential outcome of histocompatible versus histoincompatible Leu-1 depleted bone marrow transplants (2). Under "HLA-identical transplants" the data is presented as "Patients = 17; Graft Rejection = 1/6; Graft-versus-Host Disease = 2/15." As presented originally, the actual graft rejection...References1. FAHEYSARNAGALESEEGER JGRR. Immune interventions in disease. Ann Intern Med. 1987;106:257-74. LinkGoogle Scholar2. SMITHBURAKOFFWEINSTEIN BSH. Differential outcome of histocompatible versus histoincompatible Leu-1 depleted bone marrow transplants [Abstract]. Blood. 1986;68(suppl 1):292a. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 May 1987Volume 106, Issue 5Page: 783-783KeywordsBone marrowClinical trialsMonoclonal antibodies ePublished: 1 December 2008 Issue Published: 1 May 1987 PDF downloadLoading ...
Uteroglobin deficient mice---a novel animal model for IgA nephropathy?
Authors: S POURIA
Journal: Gut (2000)

The molecular mechanism(s) of immunoglobulin A (IgA) nephropathy, the most common primary renal glomerular disease worldwide, is unknown.Its pathologic features include hematuria, high levels of circulating IgA-fibronectin (Fn) complexes, and glomerular deposition of IgA, complement C3, Fn and collagen.We report here that two independent mouse models (gene knockout and antisense transgenic), both manifesting deficiency of an anti-inflammatory protein, uteroglobin (UG), develop almost all of the pathologic features of human IgA nephropathy.We further demonstrate that Fn-UG heteromerization, reported to prevent abnormal glomerular deposition of Fn and collagen, also abrogates both the formation of IgA-Fn complexes and their binding to glomerular cells.Moreover, UG prevents glomerular accumulation of exogenous IgA in UG-null mice.These results define an essential role for UG in preventing mouse IgA nephropathy and warrant further studies to determine if a similar mechanism(s) underlies the human disease.