tbuckley/cabot-search huggingface dataset:
Carcinogen Regulation-Reply
Authors: Richard J. Jones
Journal: JAMA (1982)

In Reply.—  Dr Baker and Ms Rest expound the view that has led to the elaborate testing programs and the extensive search for possible carcinogens by federal agencies in recent years. The council report on carcinogen regulation to which they refer challenges the wisdom of investing too many of our finite resources in what may be the technological version of a witch-hunt.  The council report did not imply that all laboratory testing was futile, but it did suggest that the danger of carcinogens in the environment and in the workplace has been exaggerated in some quarters, inasmuch as age-corrected cancer mortality statistics seem to be remaining fairly constant overall. Such laboratory tests as might be done for regulatory purposes should take into account the possible levels of exposure that people might experience in the workplace or in the environment. Now that we have such exquisitely sensitive measuring devices that trace
Identification of an Infected Left Ventricular Assist Device After Cardiac Transplant by Indium-111 WBC Scintigraphy
Authors: Christopher D. Roman, M Reza Habibian, William H. Martin
Journal: Clinical Nuclear Medicine (2004)

The purpose of this case report is to demonstrate the utility of multimodality imaging in the diagnosis of infection within a retained prosthetic device in the posttransplant setting.Autologous leukocytes were labeled in vitro with indium-111 oxine and were reinjected. Whole-body and SPECT images were acquired at 24 hours and correlated with contemporary CT images.Through the use of combined indium-labeled WBC scintigraphy and CT we were able to identify infection within retained left ventricular assist device tubing status postcardiac transplantation in a patient with a diagnosis of fever of unknown origin.Localization of possible infectious etiologies within the transplant population is of utmost concern. Multimodality imaging, often utilizing scintigraphic techniques, is recommended.
Transmission of Hepatitis B Virus to Classroom Contacts of Mentally Retarded Carriers
Authors: Brenda Breuer
Journal: JAMA (1985)

The risk of the spread of hepatitis B virus infection from deinstitutionalized, mentally retarded carriers to pupil and staff school contacts in the New York City public school system was measured serologically in a three-phase study from 1978 to 1982. In the third phase, undertaken in 1982, blood samples were drawn and questionnaires were completed on students and staff tested in either of the first two phases and on comparison groups with intermediate and no known school exposure to deinstitutionalized carriers. Univariate and logistic regression analyses revealed that staff and pupils with a history of classroom exposure to a hepatitis B virus carrier had significantly increased prevalences of hepatitis B virus infection (13.4%, odds ratio = 1.9; 9.3%, odds ratio = 2.5, respectively). Similarly, yearly seroconversion rates of 1.3% and 0.67% indicate that staff and, to a lesser extent, pupils are at increased risk of infection.
Cyanoacrylate Glue in Gastric Variceal Bleeding
Authors: S. Seewald, P. V. J. Sriram, M. Naga, M. B. Fennerty, J. Boyer, F. Oberti, N. Soehendra
Journal: Endoscopy (2002)

For more than 15 years, the tissue glue cyanoacrylate (n-butyl-2-cyanoacrylate) has been successfully used in Europe and many other countries, but not in the United States, for the treatment of bleeding gastric varices. The use of cyanoacrylate for the treatment of esophageal and gastric varices via the percutaneous transhepatic route, was first described by Lundequist et al. [1]. Endoscopic injection of the tissue glue for gastric variceal bleeding was first reported in 1986 [2]. Due to its excellent efficacy [3] [4] [5] [6] [7] [8] [9] [10] [11] [12] [13] [14] cyanoacrylate is considered to be the optimal initial therapy for gastric variceal bleeding by many clinicians worldwide, with the exception of the US. In Europe, cyanoacrylate has recently been approved for endoscopic use (Glubran®; GEM, Viareggio, Italy).
APOCRINE SWEAT GLAND CARCINOMA.
Authors: H. BAES, D. SUURMOND
Journal: British Journal of Dermatology (1970)

Journal Article APOCRINE SWEAT GLAND CARCINOMA: REPORT OF A CASE Get access H. BAES, H. BAES Department of Dermatology, University Hospital, Leiden, The Netherlands Search for other works by this author on: Oxford Academic Google Scholar D. SUURMOND D. SUURMOND Department of Dermatology, University Hospital, Leiden, The Netherlands Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 83, Issue 4, 1 October 1970, Pages 483–486, https://doi.org/10.1111/j.1365-2133.1970.tb15081.x Published: 01 October 1970 Article history Accepted: 14 May 1970 Published: 01 October 1970
DECLINED VISUAL ACUITY IS ASSOCIATED WITH VASCULAR DYSFUNCTION IN PATIENTS WITH DIABETES MELLITUS
Authors: Gerasimos Siasos, Nikolaos Gouliopoulos, Marilita Moschos, Evangelos Oikonomou, Georgia Siasou, Theodore Paraskevopoulos, Theodosia Konsola, Christina Kollia, Theodoros Zografos, Konstantinos Mourouzis, Marina Zaromitidou, Athanasios Papavassiliou, Christodoulos I Stefanadis, Dimitris Tousoulis
Journal: Journal of the American College of Cardiology (2015)
TYPHOID PERFORATIONS AND PERFORATIONS OF THE GALL BLADDER
Authors: G. E. Armstrong
Journal: BMJ (1910)

TYPHOID ErVOBATIONS.[OCf, 29, 191s II-l-Hernia through the Oe8oPhageal Orifice of the Diaphragm.As may be seen from Fig. 1, there was only one specimen in the series of 34 which showed a heriia at the oeso- phageal orifioe.This specimen is in the museum of Guy's Hospital, and shows the greater part of the stomach in the riht pleural cavity.Mr. Lawford Knaggs has described several cases; Mr. W. A. E. Waller has recently placed a remarkable one on record in a young man of 19; Dr. Barlay-Smith found the condition associated with great dilatation of the sigmoid colon.Mr. Rigby and the writer have recorded a case in which a partial hernia of the stomaoh through the oesophageal orifice was associated with enteroptosis.III.-Herniae through the Right Leaflet of the Diaphragm.As shown in Fig. 1, there were only two cases of hernia through the right leaflet-one in a child of 4 months, where a process of the liver, about the size of a cricket ball, occu- pied a sac formed from the expanded central tendon; and another, also in a child, where a prooess of the liver lay free in the floor of the right pleural cavity.There can be little doubt that both of these were congenital in origin and were produced by an abnormal development of the liver within the septum transversum of the embryo.Profesor Arthur Thomson has recorded a similar occurrence In the rabbit, the abnormal process of liver resembling an accessory heart.1V.-Hernia into the Pericardium.There were three cases of hernia into the pericardium through a perforation of the central tendon of the diaphragm.In the case of a man of 50 a process of omentum occupied the orifice; in a man of 47 a process of liver formed the extruded part.In neither of these cases was there a hernial sac, but in the third case, in a child at birth, the process of liver was enclosed in a sac formed by the central tendon.It is possible that the two cases in adults were the result of a former injury.Eider and Postlethwaite report a-case where the lobe of a malformed liver occupied a diverticulum of the right central tendon, the diverticulum reaching the level of the second rib.V.-Hernia through the Left Dome of the Diaphragm.Herniae through the left pleuro-peritoneal passage are four times more common than through the right, and the same statement holds true as regards the various forms of hernia which occur at the domes and sterno-costal parts of the diaphragm.As may be seen from Fig. 1, herniae occur at two sites on the left dome-an anterior or sterno-costal site, and a posterior or central site.In
F-18 FDG PET Demonstration of a Thyroid Metastasis in a Patient With Colon Cancer
Authors: Toshihiro Iguchi, Junji Matsuoka, Shuhei Sato, Yoshihiro Okumura, Masako Omori, Hirofumi Mifune, Shiro Akaki, Susumu Kanazawa
Journal: Clinical Nuclear Medicine (2007)

A 51-year-old man with a history of surgical removal of sigmoid colon cancer underwent F-18 fluorodeoxyglucose (FDG) positron emission tomography (PET) to search for distant metastases and/or local recurrence because the carcinoembryonic antigen level was elevated. F-18 FDG PET images showed increased focal FDG uptake in the left lobe of the thyroid. Computed tomography images showed thyroid tumor in the left lobe as well as F-18 FDG PET images. Thereafter he underwent thyroidectomy and the resected specimen was histopathlogically shown to have thyroid metastasis from colon cancer. F-18 FDG PET was useful to detect thyroid metastasis from colon cancer as well as the most frequently seen metastatic sites such as liver, lungs, and lymph nodes.
Beta-blockers in immediate treatment of myocardial infarction
Authors: D. Ramsdale, P. Sleight, S. Yusuf
Journal: BMJ (1980)

poststerilisation syndrome,"9 which I believe does exist.A combined approach by gynaecologists and general practitioners is likely to be most fruitful.The analysis of consulting patterns and referrals for gynaecological complaints in sterilised women, both before and after operation, and in controls is currently being explored in this practice.
THE PRECLINICAL STAGE OF HEART DISEASE
Authors: S. CALVIN SMITH
Journal: JAMA (1926)

On first thought it may seem that an attempt to establish a preclinical stage of heart disease is a refinement in diagnosis attainable only by a select few. Such is not the case. Sufficient evidence has accumulated since the days when hearts were, for the most part, studied at the bedside to show that organic heart defect is usually the result of several successive phases of development, quite comparable to the germinating grain of corn that evolves the blade, the stalk and eventually the ripened ear. Chronic myocarditis—for which a more appropriate name would often be progressive heart muscle inefficiency—is generally the ultimate end-result of accumulated heart protests which, at their inception, we once were wont to wave aside with a gesture of inconsequence.  EARLY SYMPTOMS MORE CONSTANT THAN EARLY SIGNS  Heart protests, in the beginning, are nearly always subjective symptoms alone, and the symptoms need not at all be
Frederick Chapman Robbins
Authors: Mark Henderson
Journal: The Lancet (2003)

Paediatrician, laboratory researcher, medical educator. Shared Nobel Prize in Physiology or Medicine in 1954 for developing tissue-culture technique that was used to grow poliovirus in a test tube, work that paved the way for the development of a vaccine to prevent poliovirus. Born Aug 25, 1916, in Auburn Alabama, USA; died on Aug 4, 2002, aged 86 years.
The Federal Government and Graduate Medical Education
Authors: Michael E. Whitcomb
Journal: New England Journal of Medicine (1984)

During the late 1970s, three important groups—the Association of American Medical Colleges Task Force on Graduate Medical Education, the Macy Foundation's Study Group on Graduate Medical Education, and the Graduate Medical Education National Advisory Council — conducted thoughtful studies of the future of graduate medical education in this country. Each group published its final report in 1980. Although no specific recommendations were offered on how the complex issues facing graduate medical education might be resolved, each group recognized that innovative approaches to graduate medical education might be required as a response to mounting social pressures affecting the health-care delivery system. . . .
781-1 The Weak Relation Between Blood Pressure and Left Ventricular Mass is Partially Explained by Additional Effects of Hemodynamic Volume Load and Myocardial Contractility: The Strong Heart Study
Authors: Richard B. Devereux, Mary J. Roman, Mary Paranicas, Michael O’Grady, Thomas K. Welty, Richard Fabsitz
Journal: Journal of the American College of Cardiology (1995)
New antiarrhythmic agents: a conceptually novel approach
Authors: Péter Mátyus, Tivadar Rettegi, András Varró, Julius Gy. Papp
Journal: Medicinal Research Reviews (2000)

Synthesis and biological evaluation of novel phenoxyalkyl amines exhibiting both class Ib and class III type electrophysiological properties are described. Two compounds showed excellent antiarrhythmic effects against reperfusion induced arrhythmias. © 2000 John Wiley & Sons, Inc. Med Res Rev, 20, No. 4, 294–303, 2000
Measurement of Blood Loss During Operation
Authors: W. Alsop, J. L. Emery, R. B. Zachary
Journal: BMJ (1963)

A wide range of tablets had been given to him by consultants and by me, without relief, and during a severe attack I gave him 25 mg. of " stemetil" (prochlorperazine) and 50 mg. of " phenergan " (promethazine) intramuscularly, as a result of which he slept and in due course awoke symptom-free.I then tried the combination of stemetil 5 mg., phenergan 10 mg., and " fentazin " (perphenazine) 4 mg.aa i t.d.s., and found that this kept him free from attacks.I should say that I had given each separately without result, but the trio made life tolerable for him, and he has been able for more than two years to conduct his considerable business responsibilities without the fears that formerly over- shadowed his life.It may appear to be "omnibus" medicine, but the fact is that it works, and has worked with other sufferers to whom I have, in the past two years, given the same treatment.The original patient, after some period of freedom, reduced the dosage to b.d., and even once daily, with the proviso that at the slightest sign of an attack full dosage would be resumed.I have asked M. & B. to try to make a single tablet for me, incorporating the three substances, but it appears that two manufacturers are involved, which makes this impracticable.-Iam, etc., Twickenham, Middlesex.
Drug Reaction Deaths
Authors: Fred E. Karch
Journal: JAMA (1974)

To the Editor.—  In their recent letter published inThe Journal, Talley and Laventurier (229:1043, 1974) claimed that a report from  1 confirmed an earlier article from the Boston Collaborative Drug Surveillance Program (BCDSP) (216:467, 1971) that reported deaths due to adverse drug reactions in 0.44% of hospitalized medical ward patients. Stetler, replying to the Talley and Laventurier letter in the same issue, pointed out that the 0.44% statistic was simply a restatement by the Israeli authors of the BCDSP's original figure.  However, the results actually reported in the Israeli article were that  drug-induced deaths were observed among the monitored patients in Israel (p 622). Thus, the report from  can in no sense be regarded as supporting the use of the 0.44% mortality statistic and, in fact, contradicts it.  In an area as important as the problem of adverse drug reactions, it is unfortunate when the limited
Dyserythropoiesis in iron‐deficiency anemia: Ultrastructural reassessment
Authors: Maria Rozman, Teresa Masat, Evarist Feliu, Ciril Rozman
Journal: American Journal of Hematology (1992)

Abstract Iron deficiency is usually included among the causes of acquired dyserythropoiesis. This concept was derived mainly from light microscopic studies. To reassess such a notion at ultrastructural level, a transmission electron microscopic evaluation of bone marrow was performed in seven patients with iron‐deficiency anemia. In contrast to the widely accepted concept, derived from light microscopic studies, only a small proportion (2–4%, not different from controls) of erythroblasts displayed some of the features of nuclear dyserythropoiesis. On the contrary, when examining the cytoplasm, we found a significantly increased number of void ropheocytotic vesicles in the majority of late erythroblasts as compared to controls (P &lt; 0.001). This feature may be considered as an ultrastructural marker of iron deficiency and is consistent with the present knowledge on transferrin‐mediated delivery of iron to the cell. © 1992 Wiley‐Liss, Inc.
Fractures of the Limbs: The Relationship Between Mechanisms and Treatment
Authors: John D. Hsu
Journal: JAMA (1982)

Dr Robert Soeur of Belgium has brought together an extremely impressive collection of fractures that he and Dr Robert Remy treated. The original text is translated by T. J. Fairbank, an English orthopedic surgeon of note and an author of orthopedic texts in his own right. There are profuse, overabundant illustrations, including many classic examples of extremity fractures that a practicing orthopedic or trauma surgeon would encounter. They are presented using numerous excellent serial roentgenograms and illustrations that cover the right-hand page, with explanations and clinical history on the left-hand page. There are eight chapters and 840 pages. The pages are large, 8×11 1/2 inches, and the entire volume weighs more than 7 lb. The opening statement of the preface—"This work is neither a treatise, nor a teaching manual...."—gives the nature of the presentation, reflecting "the results of many years of experience both in University Hospitals and in private practice."
Targeted Next-Generation Sequencing Identifies Pathogenic Variants in Familial Congenital Heart Disease
Authors: Gillian M. Blue, Edwin P. Kirk, Eleni Giannoulatou, Sally L. Dunwoodie, Joshua W.K. Ho, Desiree C.K. Hilton, Susan M. White, Gary F. Sholler, Richard P. Harvey, David S. Winlaw
Journal: Journal of the American College of Cardiology (2014)
Which Method used for the Assessment of Left Ventricule Ejection Fraction is more Correlated with the Left Ventricule Global Strain?
Authors: Süleyman Karakoyun, Mustafa Ozan Gürsoy, Kamuran Kalkan, Zakir Lazoğlu, Halil İbrahim Tanboğa, Tayyar Gökdeniz
Journal: Journal of the American College of Cardiology (2013)
523 Morphology, and stimulation-induced release of histamine and arachidonic acid metabolttes from mouse bone marrow-derived mast cells that from been coculitured with mouse fibroblasts
Authors: F. Levi-Schaffer, E.T. Dayton, K.F. Austen, A. Hein, J.P. Caulfield, P.M. Gravallese, F.T. Liu, R.L. Stevens
Journal: Journal of Allergy and Clinical Immunology (1988)
Can doctors be trained in a 48 hour working week?
Authors: A. Hartle, S. Gibb, A. Goddard
Journal: BMJ (2014)

<b>Andrew Hartle</b> and <b>Sarah Gibb</b> find no evidence that implementation of the European Working Time Directive has led to a decline in the quality of training. But <b>Andrew Goddard</b> thinks that 48 hours doesn't give sufficient time for some specialties and notes trainees' dissatisfaction
A rash in a patient with neutropenia
Authors: R. T. Woolf, T. Yeghen, H. d. P. Menage
Journal: BMJ (2012)

A 72 year old man with relapsed acute myeloid leukaemia developed a rash seven days after starting a combined chemotherapy regimen (fludarabine, cytarabine, granulocyte colony stimulating factor, and idarubicin). He first noticed a painful lesion on his left forefoot, and over the next seven days he developed similar lesions on the left lower limb (fig 1⇓), right thigh, and face. He was referred for a dermatological opinion on day 14.



He was pancytopenic, with undetectable neutrophils and lymphocytes. No prophylactic antibacterial or antifungal drugs had been given. On the fifth day after chemotherapy he had developed a fever with new consolidation on chest radiography. He had been started on empirical broad spectrum antibiotics (piperacillin-tazobactam and gentamicin, with the addition of teicoplanin on day 10 owing to meticillin resistant Staphylococcus aureus being cultured in sputum). Despite this, he remained febrile, with worsening inflammatory markers (C reactive protein 270 mg/L; reference range <5 mg/L; 1 mg/L=9.52 nmol/L) and was being managed in an isolation room. He was otherwise asymptomatic and remained stable from a cardiovascular point of view. Chest computed tomography on day 14 showed bilateral multifocal consolidation with faint peripheral halos.



### 1 How would you describe the morphology of the presenting rash?

#### Short answer

There are two annular macular erythematous lesions overlying the left knee. The largest is about 3 cm in diameter and has a dusky necrotic centre. The smaller 1 cm lesion also has a darker centre.

#### Long answer

Overlying the left knee there are two annular macular erythematous lesions. The largest measures about 3 cm in diameter and has a dusky necrotic centre. The smaller 1 cm lesion also has …
Abstract 4015: <i>The role of IL-6/STAT3 axis in the transformation of Epstein-Barr Virus (EBV) infected-immortalized nasopharyngeal epithelial cells</i>
Authors: GUITAO ZHANG
Journal: Cancer Research (2010)

Abstract The role of IL-6/STAT3 axis in the transformation of Epstein-Barr Virus (EBV) infected-immortalized nasopharyngeal epithelial cells. Zhang Guitao, Tsang Chi Man, Chen Honglin, Tsao Sai Wah. Nasopharyngeal carcinoma (NPC) is rare throughout most parts of the world but common in certain geographic area, such as Southern China including Hong Kong. The etiology is based on intricate interactions among environmental factors, genetic susceptibility and Epstein-Barr virus (EBV) infection. Elevated antibody titers to EBV antigens are regularly observed in NPC patients. However, little information is available concerning the role of EBV in the early stage of NPC carcinogenesis. Our laboratory has established and characterized immortalized nasopharyngeal epithelial cells lines as premalignant nasopharyngeal cell models to examine for the transformation property of EBV infection in early stage of NPC development. Our results show that EBV infection activates STAT3 in immortalized nasopharyngeal epithelial cells. We had previously reported that the EBV-encoded LMP1 could upregulate IL-6 secretion to activate STAT3 signaling. Interestingly, we observed that activation of STAT3 in EBV-infected immortalized nasopharyngeal epithelial cells is highly susceptible to the induction by inflammatory cytokines, notably IL-6. Using quantitative real-time PCR, up-regulation of LMP1 was observed after IL-6 treatment on a time course dependent manner. An analysis of IL-6 receptor (IL-6R) indicated that EBV-infected nasopharyngeal epithelial cells have elevated level of IL-6R expression compared with uninfected cells. Activation of STAT3 signaling in immortalized nasopharyngeal epithelial cells by expressing a flag-tagged constitutively active STAT3-C confers transformed properties to cells. Our results support a model that EBV infection may predispose the aberrant STAT3 signaling for inflammatory cytokines involving the activation of LMP1/IL-6/STAT3 axis in premalignant nasopharyngeal epithelial cells. Enhanced STAT3 activation in EBV-infected epithelial cells by stromal inflammatory cytokines could result in irregular-gene expressions and cell signaling essential for malignant transformation, which may represent a crucial function of EBV infection in the development of nasopharyngeal carcinoma. (This project is supported by The Research Grant Council (Hong Kong) and Area of Excellence on Nasopharyngeal Carcinoma Research Center (Hong Kong)). Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 101st Annual Meeting of the American Association for Cancer Research; 2010 Apr 17-21; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2010;70(8 Suppl):Abstract nr 4015.
The future of locality commissioning
Authors: N. Mays
Journal: BMJ (1997)

GP fundholding was introduced by the Conservative government to involve general practitioners in shaping local health services1: individual practices acted as agents for their patients, using their own budgets to bring about quality and efficiency improvements in hospital and community health services. A range of alternative, unofficial schemes has emerged at local level (non-fundholding, general practitioner led commissioning, and locality commissioning2 3 4) led by non-fundholders who want to help shape local health services but are sceptical about holding an individual practice budget. These schemes have received less attention than fundholding and its derivatives,5 6 but this issue of the BMJ includes a rare attempt to evaluate locality commissioning in Avon, where there seem to be modest benefits at a much lower cost than …