tbuckley/cabot-search huggingface dataset:
Mutant ADA2 in Vasculopathies
Authors: Jose Bras, Rita Guerreiro, Gustavo C Santo
Journal: New England Journal of Medicine (2014)

CRT-D between patients with ischemic cardiomyopathy with NYHA class I or class II and patients with nonischemic cardiomyopathy.Hazard ratios were similar in these groups (0.66, 0.65, and 0.57, respectively), which denoted a similar effect size.We do, however, agree with the correspondents that because of sample-size limitations, more prospective data are necessary to corroborate the beneficial effects of CRT-D among patients with asymptomatic ischemic cardiomyopathy.
On the “First International Symposium on the Developmental Aspects of Androgen Excess”1The reviews in this issue are based on presentations made at the First International Symposium on the Developmental Aspects of Androgen Excess Disorders, 14–15 June 1997, Minneapolis, MN, USA.1
Authors: Paul Saenger, Ricardo Azziz
Journal: Trends in Endocrinology and Metabolism (1998)
Disparities in Participation in Cancer Clinical Trials
Authors: Nina H Bjarnason
Journal: JAMA (2004)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Severe dermatitis, multiple allergies, and metabolic wasting syndrome caused by a novel mutation in the N-terminal plakin domain of desmoplakin
Authors: Maeve A. McAleer, Elizabeth Pohler, Frances J.D. Smith, Neil J. Wilson, Christian Cole, Stuart MacGowan, Jennifer L. Koetsier, Lisa M. Godsel, Robert M. Harmon, Robert Gruber, Debra Crumrine, Peter M. Elias, Michael McDermott, Karina Butler, Annemarie Broderick, Ofer Sarig, Eli Sprecher, Kathleen J. Green, W.H. Irwin McLean, Alan D. Irvine
Journal: Journal of Allergy and Clinical Immunology (2015)

Severe dermatitis, multiple allergies, and metabolic wasting (SAM) syndrome is a recently recognized syndrome caused by mutations in the desmoglein 1 gene (DSG1). To date, only 3 families have been reported.We studied a new case of SAM syndrome known to have no mutations in DSG1 to detail the clinical, histopathologic, immunofluorescent, and ultrastructural phenotype and to identify the underlying molecular mechanisms in this rare genodermatosis.Histopathologic, electron microscopy, and immunofluorescent studies were performed. Whole-exome sequencing data were interrogated for mutations in desmosomal and other skin structural genes, followed by Sanger sequencing of candidate genes in the patient and his parents.No mutations were identified in DSG1; however, a novel de novo heterozygous missense c.1757A>C mutation in the desmoplakin gene (DSP) was identified in the patient, predicting the amino acid substitution p.His586Pro in the desmoplakin polypeptide.SAM syndrome can be caused by mutations in both DSG1 and DSP. Knowledge of this genetic heterogeneity is important for both analysis of patients and genetic counseling of families. This condition and these observations reinforce the importance of heritable skin barrier defects, in this case desmosomal proteins, in the pathogenesis of atopic disease.
n–3 Fatty Acids and Cardiovascular Outcomes in Patients with Dysglycemia
Authors: Jackie Bosch, Hertzel C Gerstein, Gilles R Dagenais, Rafael Díaz, Leanne Dyal, Hyejung Jung, Aldo P Maggiono, Jeffrey Probstfield, Ambady Ramachandran, Matthew C Riddle, Lars E Rydén, Salim Yusuf, Véronique Kerlan
Journal: New England Journal of Medicine (2012)

The use of n-3 fatty acids may prevent cardiovascular events in patients with recent myocardial infarction or heart failure. Their effects in patients with (or at risk for) type 2 diabetes mellitus are unknown.In this double-blind study with a 2-by-2 factorial design, we randomly assigned 12,536 patients who were at high risk for cardiovascular events and had impaired fasting glucose, impaired glucose tolerance, or diabetes to receive a 1-g capsule containing at least 900 mg (90% or more) of ethyl esters of n-3 fatty acids or placebo daily and to receive either insulin glargine or standard care. The primary outcome was death from cardiovascular causes. The results of the comparison between n-3 fatty acids and placebo are reported here.During a median follow up of 6.2 years, the incidence of the primary outcome was not significantly decreased among patients receiving n-3 fatty acids, as compared with those receiving placebo (574 patients [9.1%] vs. 581 patients [9.3%]; hazard ratio, 0.98; 95% confidence interval [CI], 0.87 to 1.10; P=0.72). The use of n-3 fatty acids also had no significant effect on the rates of major vascular events (1034 patients [16.5%] vs. 1017 patients [16.3%]; hazard ratio, 1.01; 95% CI, 0.93 to 1.10; P=0.81), death from any cause (951 [15.1%] vs. 964 [15.4%]; hazard ratio, 0.98; 95% CI, 0.89 to 1.07; P=0.63), or death from arrhythmia (288 [4.6%] vs. 259 [4.1%]; hazard ratio, 1.10; 95% CI, 0.93 to 1.30; P=0.26). Triglyceride levels were reduced by 14.5 mg per deciliter (0.16 mmol per liter) more among patients receiving n-3 fatty acids than among those receiving placebo (P<0.001), without a significant effect on other lipids. Adverse effects were similar in the two groups.Daily supplementation with 1 g of n-3 fatty acids did not reduce the rate of cardiovascular events in patients at high risk for cardiovascular events. (Funded by Sanofi; ORIGIN ClinicalTrials.gov number, NCT00069784.).
College inquiry clears hospital's cardiology services
Authors: Gavin Foster
Journal: BMJ (2000)

A consultant physician suspended on full pay for the past year after he questioned the competence of fellow physicians is to leave his post.

The announcement that Dr Anthony Bainbridge is to pursue his career elsewhere came at a press briefing given last week by hospital managers at the Isle of Wight Healthcare NHS Trust.

Dr Bainbridge was suspended from his duties …
Phytoestrogens and Risk of Lung Cancer—Reply
Authors: Matthew B. Schabath, Margaret R. Spitz
Journal: JAMA (2006)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Quantification of Functional Mitral Regurgitation by Real-Time 3D Echocardiography
Authors: Nina Ajmone Marsan, Jos J.M. Westenberg, Claudia Ypenburg, Victoria Delgado, Rutger J. van Bommel, Stijntje D. Roes, Gaetano Nucifora, Rob J. van der Geest, Albert de Roos, Johan C. Reiber, Martin J. Schalij, Jeroen J. Bax
Journal: JACC. Cardiovascular imaging (2009)
Analysis of strain and regional variation in gene expression in mouse brain
Authors: Paul Pavlidis, William S Noble
Journal: Genome biology (2001)

We performed a statistical analysis of a previously published set of gene expression microarray data from six different brain regions in two mouse strains. In the previous analysis, 24 genes showing expression differences between the strains and about 240 genes with regional differences in expression were identified. Like many gene expression studies, that analysis relied primarily on ad hoc 'fold change' and 'absent/present' criteria to select genes. To determine whether statistically motivated methods would give a more sensitive and selective analysis of gene expression patterns in the brain, we decided to use analysis of variance (ANOVA) and feature selection methods designed to select genes showing strain- or region-dependent patterns of expression.Our analysis revealed many additional genes that might be involved in behavioral differences between the two mouse strains and functional differences between the six brain regions. Using conservative statistical criteria, we identified at least 63 genes showing strain variation and approximately 600 genes showing regional variation. Unlike ad hoc methods, ours have the additional benefit of ranking the genes by statistical score, permitting further analysis to focus on the most significant. Comparison of our results to the previous studies and to published reports on individual genes show that we achieved high sensitivity while preserving selectivity.Our results indicate that molecular differences between the strains and regions studied are larger than indicated previously. We conclude that for large complex datasets, ANOVA and feature selection, alone or in combination, are more powerful than methods based on fold-change thresholds and other ad hoc selection criteria.
Sexual Assaults Among University Students
Authors: Rebecca B. Reingold, Lawrence O. Gostin
Journal: JAMA (2015)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
ACCESSORY LOBES OF LIVER AND THEIR SIGNIFICANCE IN ROENTGEN DIAGNOSIS
Authors: H J KATZ, A J WILLIAMS
Journal: Annals of Internal Medicine (1952)

Case Reports1 March 1952ACCESSORY LOBES OF LIVER AND THEIR SIGNIFICANCE IN ROENTGEN DIAGNOSISHILLIARD J. KATZ, M.D., A. JUSTIN WILLIAMS, M.D.HILLIARD J. KATZ, M.D.Search for more papers by this author, A. JUSTIN WILLIAMS, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-36-3-880 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptAnomalous or accessory lobes arising from the right lobe of the liver are rare but, when present, give rise to diagnostic problems that must be solved. Only a small number of such cases have been reported. Roques and Sohier4and Hardisty et al.2presented individual cases in which deformity of the right dome of the diaphragm was found on routine x-ray examination of the chest. In each case the patient was asymptomatic. In each instance pneumoperitoneum revealed a smooth mass arising from the superior surface of the liver. One (Roques and Sohier) was diagnosed echinococcus cyst, the other (Hardisty et...Bibliography1. FriedmanSolis-CohenLevine PSLS: Accessory lobe of the liver and its significance in roentgen diagnosis, Am. J. Roentgenol. 57: 601 (May) 1947. Google Scholar2. HardistyKearneyBrooks NMEAFP: Report of a case of an anomalous lobe of the liver, Am. J. Roentgenol. 60: 486 (Oct.) 1948. Google Scholar3. KornblumStephenson KGW: Anomalous enlargement of the liver and a dissecting hematoma of the phrenic nerve, Am. J. Roentgenol. 24: 38-41, 1930. Google Scholar4. RoquesSohier PH: Lobe accessoire de la face convexe du foie, Ann. d'anat. path. 12: 953-959, 1935. Google Scholar5. Wagner A: Four cases of diaphragmatic intumescence, Acta radiol. 26: 239, 1945. CrossrefGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: San Francisco, California*Received for publication June 12, 1951. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byLiverTorsion of a hepatic lobe in the neonate — ultrasound findingsGutartige Primärtumoren der Bronchien und LungenDigestive SystemINTRATHORACIC ACCESSORY LOBE OF THE LIVER*S. A. KAUFMAN, M.D., IRVING M. MADOFF, M.D.PARTIAL EVENTRATION OF THE RIGHT DIAPHRAGM (CONGENITAL DIAPHRAGMATIC HERNIATION OF THE LIVER)*ALFRED VOGL, M.D., F.A.C.P., ALLAN SMALL, M.D. 1 March 1952Volume 36, Issue 3Page: 880-883KeywordsLiverThorax Issue Published: 1 March 1952 PDF downloadLoading ...
Abstract 1748: Novel Ig1 inhibitors of the Axl tyrosine kinase that block Gas6-inducible receptor activation
Authors: William J. Welsh, Vladyslav Kholodovych, Raymond Birge, Tom Comollo, Stanley Kimani, Kamal Singh
Journal: Cancer Research (2014)

Abstract Tyro-3, Axl, and Mer (abbreviated TAMs) are a family of three homologous receptor tyrosine kinases (RTKs) expressed predominantly on myeloid-derived hematopoietic cells and epithelial cells that function as inhibitory receptors that dampen inflammatory responses and maintain tissue tolerance. Both TAMs and their ligands (vitamin K activated proteins that consist of Gas6 and Protein S) are overexpressed in many human malignancies and expression is associated with more aggressive cancer staging, drug resistance, and poorer patient survival. Based on their clinical importance, there has been considerable effort to generate anti-TAM cancer therapeutics in the form of small molecule tyrosine kinase inhibitors, monoclonal antibodies, and soluble receptor traps that capture TAM ligands and prevent receptor activation. However, whereas several tyrosine kinase inhibitors have been reported, the high degree of sequence conservation in the TAM kinase domain is associated with lack of specificity and off target effects. To generate more selective inhibitors of TAMs, we have targeted the Ig1 domain of Axl, a ligand-binding region in the extracellular domain that gives TAMs their unique structural features. From the X-ray crystallographic structure of Gas6 in complex with the human Axl ectodomain (PDB 2c5d), two unique sites were targeted that include (i) the major binding pocket around Glu59 in Axl that interacts with Arg310 and Lys312 in Gas6, and (ii) the main hydrophobic interface between the Ig1 and the Lg1 that is required for Gas6-inducible dimerization. Virtual screening of the ZINC molecular data base was performed, and several drug-like compounds were selected based on ligand-Gas6 docking. We report on the characterization of two novel types of Axl inhibitors that include a triazolo pyridazine compound that targets the Ig1 binding pocket, and a 3-cyanocoumarin compound that targets the Ig1-Lg1 interface. Both compounds show activity on human Axl reporter lines, and therefore may represent a new class of Axl inhibitors with potential applications for anticancer therapy. Citation Format: William J. Welsh, Vladyslav Kholodovych, Raymond Birge, Tom Comollo, Stanley Kimani, Kamal Singh. Novel Ig1 inhibitors of the Axl tyrosine kinase that block Gas6-inducible receptor activation. [abstract]. In: Proceedings of the 105th Annual Meeting of the American Association for Cancer Research; 2014 Apr 5-9; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2014;74(19 Suppl):Abstract nr 1748. doi:10.1158/1538-7445.AM2014-1748
Modern Methods of Feeding in Infancy and Childhood.
Authors: H. P. Donald
Journal: JAMA (1926)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
RECURRENT BILATERAL SPONTANEOUS PNEUMOTHORAX TREATED WITH ARTIFICIAL HEMOTHORAX
Authors: L A GROSSMAN
Journal: Annals of Internal Medicine (1953)

Case Reports1 December 1953RECURRENT BILATERAL SPONTANEOUS PNEUMOTHORAX TREATED WITH ARTIFICIAL HEMOTHORAXLAURENCE A. GROSSMAN, M.D., F.A.C.P.LAURENCE A. GROSSMAN, M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-39-6-1303 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptSpontaneous pneumothorax of nontuberculous origin is frequently encountered. Often there is a single attack, from which the patient recovers uneventfully. Sometimes there are recurring attacks on the same or on the opposite side of the chest. Under such circumstances, treatment is indicated to prevent further recurrence if possible. Chemical irritation of the pleura to the end of obliterating the pleural cavity has been advocated. In 1906 Spengler1suggested the use of silver nitrate to induce adhesive pleuritis. In 1948 Brock2reported the successful treatment of several patients with recurrent pneumothorax by this method. Hypertonic glucose solution, gomenol-in-oil, talc and other...Bibliography1. Spengler L: Zur Chirurgie des Pneumothorax, Mitteilung über 10 eigene Fälle von geheiltem tuberculösem Pneumothorax: Verbunden in 6 Fällen mit gleichzeitiger Heilung der Lungentuberkulose, Beitr. z. klin. Chir. 49: 68-89, 1906 (quoted by Hennel and Steinberg). Google Scholar2. Brock RC: Recurrent and chronic spontaneous pneumothorax, Thorax 3: 88-111 (June) 1948. CrossrefMedlineGoogle Scholar3. Crenshaw GL: Treatment and surgical indications of non-tuberculous, non-traumatic spontaneous pneumothorax, Dis. of Chest 17: 369-387 (Apr.) 1950. CrossrefGoogle Scholar4. MeadeBlades RHBB: Surgical treatment of recurrent and chronic spontaneous pneumothorax of non-tuberculous origin, Am. Rev. Tuberc. 60: 683-698 (Dec.) 1949. MedlineGoogle Scholar5. WatsonRobertson EEC: Recurrent spontaneous pneumothorax. Report of three cases, Arch. Surg. 16: 431-438 (Jan.) 1928. CrossrefGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: LAURENCE A. GROSSMAN, M.D., F.A.C.P.Affiliations: Nashville, Tennessee*Received for publication August 10, 1953.From the Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byPleural Disease in Diffuse Cystic Lung DiseasesIntrathoracic fibrin glue for postoperative pleuropulmonary fistulaSurgical management of spontaneous pneumothorax by bleb ligation and pleural dry sponge abrasionSpontaneous Pneumothorax in Pulmonary EmphysemaSPONTANEOUS PNEUMOTHORAXPleurectomy for recurrent spontaneous pneumothoraxSpontaneous pneumothorax 1 December 1953Volume 39, Issue 6 Page: 1303-1307 Keywords Glucose Nitrates Talc Thorax ePublished: 1 December 2008 Issue Published: 1 December 1953 PDF downloadLoading ...
Timoma Tedavisi: Sistematik Bir Derleme ve Tedavi Kılavuzu
Authors: Conrad B. Falkson, MBChB, Andrea Bezjak, Gail Darling, Richard Gregg, Richard Malthaner, Donna E. Maziak, Mdcm, Edward Yu, Christopher A. Smith, Sheila McNair, Yee C. Ung, William K. Evans
Journal: Journal of Thoracic Oncology (2009)
PREVENTION OF THE HBsAg CARRIER STATE IN NEWBORN INFANTS OF MOTHERS WHO ARE CHRONIC CARRIERS OF HBsAg AND HBeAg BY ADMINISTRATION OF HEPATITIS-B VACCINE AND HEPATITIS-B IMMUNOGLOBULIN
Authors: VivianC.W Wong, HenkW Reesink, HenriettaM.H Ip, P Nco Lelie, EvelineE Reerink-Brongers, C.Y Yeung, H.K Ma
Journal: The Lancet (1984)