Studies of the Pathogenesis of Human Hypertension
Authors: JACQUES GENEST
Journal: Annals of Internal Medicine (1961)

Article1 July 1961Studies of the Pathogenesis of Human HypertensionThe Adrenal Cortex and Renal Pressor MechanismJACQUES GENEST, M.D., F.R.C.P., (C)F.A.C.P., P. BIRON, M.D., E. KOIW, PHYS. ENG., W. NOWACZYNSKI, D.SC., R. BOUCHER, PH.D., M. CHRÉTIEN, M.D.JACQUES GENEST, M.D., F.R.C.P., (C)F.A.C.P., P. BIRON, M.D., E. KOIW, PHYS. ENG., W. NOWACZYNSKI, D.SC., R. BOUCHER, PH.D., M. CHRÉTIEN, M.D.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-55-1-12 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptAt the meeting of The American College of Physicians in Los Angeles in 1956 we reported our preliminary findings of a significantly greater urinary aldosterone excretion in patients with severe essential and malignant hypertension than in normal subjects. This study was based on a biological determination of a purified aldosterone fraction obtained after two successive chromatographic purifications of the crude, neutral extract of acidified urine (1). These studies of the relationship of adrenocortical hormones to hypertensive disease have been continued and, by using a more specific physicochemical method for the isolation and determination of urinary aldosterone, have been extended to...References1. GENESTLEMIEUXDAVIGNONKOIWNOWACZYNSKISTEYERMARK JGAEWP: Human arterial hypertension: a state of mild, chronic hyperaldosteronism? Science 123: 503, 1956. CrossrefMedlineGoogle Scholar2. GENESTKOIWNOWACZYNSKILEBOEUF JEWG: Further studies on urinary aldosterone in human arterial hypertension. Proc. Soc. Exp. Biol. Med. 97: 676, 1958. CrossrefMedlineGoogle Scholar3. GENESTKOIWNOWACZYNSKISANDOR JEWT: Study of a large urinary steroid spectrum in normal subjects and hypertensive patients. Acta Endocr. 35: 413, 1960. 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CHRÉTIEN, M.D.Affiliations: Montréal,Received for publication April 24, 1961.From the Clinical Research Department, Hôtel-Dieu de Montréal, 3840 Rue St-Urbain, Montréal 18, Canada.Presented at the Forty-second Annual Session of The American College of Physicians, May 8-12, 1961, Bal Harbour, Fla.This work was supported by grants of the Ministries of Health (Federal-Provincial Plan), the Medical Research Council of Canada, the Life Insurance Medical Research Fund of New York, and the Ciba Pharmaceutical Co., Montréal.Dr. Chrétien is a Research Fellow of the Medical Research Council, Ottawa, Canada.Requests for reprints should be addressed to Jacques Genest, M.D., Director, Clinical Research Dept., Hôtel-Dieu de Montréal, 3840 Rue St-Urbain, Montréal 18, Can. 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