tbuckley/cabot-search huggingface dataset:
David James Mearns Anderson John Malcolm Barnes Deb Kumar Bose William ("Bill") Kerr Noble Brown Bidhan Chandra Chatterjee Marion Angela Crawford Margaret Anne Dickinson Sir John Rogers Ellis David Idris Harries James Henderson Levack John Sumner Stead David Stephen Peck
Authors: D J Poll, W O Roberts, A. Chaudhuri, C. K Brown, L R Payne, E O Lundholm, D. Slater, K. Dickinson, C. Ellis, G. Harries, I. Drever, M. Stead, R. Nunn
Journal: BMJ (1998)

# David James Mearns Anderson {#article-title-2}

Consultant obstetrician and gynaecologist Barnsley 1996-8 ( b Aberdeen 1956; q Aberdeen 1980; FRCSG, MRCOG), d 8 July 1998. He felt strongly that as his specialty was surgical appropriate experience in the wider aspects of intra-abdominal surgery, particularly urology, was necessary, and spent his early training in quite a few varied posts in Liverpool and Sheffield, followed by a general registrar rotation in Sheffield. At a research post in Aberdeen he developed a belief in evidence based practice, which led eventually to an MD. After this he spent four years as a consultant in North Carolina, having become disillusioned with what he saw as a less than meritocratic British medical system. At Barnsley he developed a one step outpatient service for postmenopausal bleeding, reducinthe waiting lists by their active management, and was involved in teaching. He was a bon vivant, who loved entertaining, and had an encyclopaedic knowledge of rhythm and blues. Latterly he was admitted as a member of the Society of Friends, a great solace to him. He leaves a wife, Melly, and a daughter.

# John Malcolm Barnes {#article-title-3}

Consultant orthopaedic surgeon Ysbyty Gwynedd Bangor, 1980-96 ( b 1943 to a father who was a professor of orthopaedic surgery; q Middlesex 1967; FRCS), died from carcinoma of the thyroid on Christmas Day 1997. Before taking up his consultant post he spent some time working in South Africa. A deft and decisive surgeon, he specialised in elbow replacement. Though bemused by the machinations of medical politics, he retained a strong sense of fair play. He was a keen sportsman, as spectator and participant, and mountaineer, climbing locally as well as in the Alps and the Karakorams. During his short retirement he took pride in his showpiece garden. His first marriage was dissolved and he leaves a second wife, Margaret, and two sons (one a surgeon) of his first …
Experts Describe Optimal Symptom Management for Hospice Patients
Authors: M J Friedrich
Journal: JAMA (1999)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Medical Complications During Pregnancy.
Authors: Gerard N. Burrow, Thomas F. Ferris
Journal: Annals of Internal Medicine (1970)

Chapter 1: Obstetric Management of the High-Risk Patient Chapter 2: Diabetes in Pregnancy Chapter 3: Hypertensive Disorders in Pregnancy Chapter 4: Hematologic Aspects of Pregnancy Chapter 5: Venous Thromboembolism During Pregnancy Chapter 6: Pregnancy and Cardiovascular Disease Chapter 7: Thyroid Diseases Chapter 8: Pituitary and Adrenal Disorders of Pregnancy Chapter 9: Calcium Homeostasis and Disorders of Calcium Metabolism During Pregnancy and Lactation Chapter 10: Clinical Genetics Chapter 11: Ethical Issues in Obstetrics Chapter 12: Emergency Management of the Obstetric Patient Chapter 13: Renal Diseases Chapter 14: Gastrointestinal Complications Chapter 15: Liver Diseases Chapter 16: Bacterial, Fungal, and Parasitic Disease Chapter 17: Viral Infections Chapter 18: Pulmonary Diseases Chapter 19: Neurologic Complications Chapter 20: Rheumatic Disease in Pregnancy Chapter 21: Immunology of Pregnancy Chapter 22: The Skin in Pregnancy Chapter 23: Neoplastic Diseases Chapter 24 : Psychiatric Complications Chapter 25: Substance Abuse
Abstract 12428: Evaluation of Symptomatic Carotid Plaques by Tissue Characterization Using Integrated Backscatter Ultrasound and Magnetic Resonance Imaging
Authors: Kiyofumi Yamada, Masanori Kawasaki, Shinichi Yoshimura, Yukiko Enomoto, Takahiko Asano, Shinya Minatoguchi, Toru Iwama
Journal: Circulation (2010)

Background: Unstable carotid plaques that consist of large lipid pool and intra-plaque hemorrhage are more likely to cause cerebral infarction. We previously developed an integrated backscatter (IB...
A comparison of two allergen challenge methods in asthmatics using inhaled corticosteroids
Authors: W.Y. Lee, T. Southworth, D. Singh
Journal: European Respiratory Journal (2013)

Rationale: The dosimeter and tidal breathing method are the two most common inhalational allergen challenge methods used in clinical trials.They have been used in inhaled corticosteroid (ICS) naive asthmatics only.

Aim: To compare these two methods in asthmatics taking ICS

Method: 14 asthmatics taking ICS<1000mcg BDP equivalent were recruited (mean age:40yrs,mean FEV1% pred:89.0%,mean ICS dose:396mcg).

Each patient had an allergen challenge using the dosimeter method first, then the tidal breathing method at least 2wks later.For the dosimeter method, the incremental dose challenge was used.FEV1 was measured 10hrs post allergen inhalation.Induced sputum was collected at baseline and 24hrs post allergen challenge.The early asthmatic response(EAR) is expressed as area under curve(AUC) percent change in FEV1 during first 2hrs(AUC0-2h) and maximum fall in FEV1 during this time.The late asthmatic response(LAR) is expressed as AUC percent change in FEV1 during 4-10hrs(AUC4-10h) and maximum fall in FEV1 during this time.

Result: There was no significant difference in the mean maximum fall in FEV1 during the EAR and LAR(p=0.74,p=0.95 respectively), or mean EAR AUC0-2h and LAR AUC4-10h between the two methods(p=0.95,p=0.86 respectively).Bland Altman analysis indicated good agreement between both methods.

There was a statistically significant rise in post allergen sputum eosinophil% count from baseline after the dosimeter and tidal breathing method(p=0.010,p=0.004 respectively).

Conclusion: The dosimeter and tidal breathing method show high degree of comparability and both methods induce an allergic inflammatory response in asthmatics on ICS.Both methods can be used in clinical trials to study drug effects.
Case-control study for risk factors for Q Fever in southwest England and Northern Ireland
Authors: H J Orr, H Christensen, B Smyth, D AB Dance, D Carrington, I Paul, J M Stuart
Journal: Eurosurveillance (2006)

Q fever (Coxiella burnetti) is thought to account for 1% (700 cases) of community acquired pneumonia in the United Kingdom each year, and can result in serious complications such as endocarditis. Although outbreaks have frequently been reported worldwide, the causes are often not clearly identified and there have been few studies of risk factors in sporadic cases. We conducted a matched case-control study. Cases of acute Q fever in people aged over 15 years in southwest England and Northern Ireland were identified from January 2002 to December 2004. Controls were matched for age, sex and the general practice at which they were registered. Questionnaires asking about contact with animals, and leisure and work activities, were posted to cases and controls. Questionnaires were completed by 39/50 (78%) of the cases and 90/180 (50%) of the controls. In the single variable analysis, occupational exposure to animals or animal products was the only risk factor associated with cases at the 5% level (P=0.05, odds ratio (OR) 3.4). Long term illness appeared to be significantly protective (P=0.03, OR 0.3). In multivariable analysis the strength of association between occupational exposure and illness remained high (OR 3.6, 95% confidence interval (CI) 0.9 to 14.8) and smoking emerged as a possible risk factor. This is the first case-control study to identify occupational exposure to animals or animal products as the most likely route of infection in sporadic cases as opposed to outbreaks.
418. Adaptation of the Wave Bioreactor to Baculoviral Production of AAV Vectors: Scale-Up Considerations
Authors: Haifeng Chen, Shangzhen Zhou, Glenn P. Pierce, Peter Colosi
Journal: Molecular Therapy (2004)

The AAV vector is one of the most promising delivery systems for gene therapy applications requiring long-term gene expression. AAV vectors have been used successfully to treat several animal models of human disease including hemophilia A and B, Parkinson's disease, glioma, and heart failure. Preclinical success with hemophilia B has led Avigen to initiate an ongoing clinical trail to evaluate the use of an AAV Factor IX vector for the treatment of severe hemophilia B. AAV vectors are most commonly produced by transient transfection of production plasmids into adherent 293 cells. While efficient at smaller scale, and sufficient to support clinical development, this method is not easily scaled and requires a high degree of operator skill. Several alternative production methods involving packaging cells lines combined with helper viruses have been evolved to address the problem of large scale AAV vector production, but to date, none of these methods have been demonstrated to be both efficient and scalable. Recently, Urabe et al. have developed a method where AAV vector production occurs in suspension cultured Sf9 cells after infection by baculoviral vectors containing AAV production genes. The system was reported to be highly productive at small scale with yields of up to 1e14 vector genomes (vg)/liter equivalent. By optimization of cell growth and infection parameters we have been able to routinely achieve production yields exceeding 1e14 vg/liter equivalent using a number of different AAV vector constructs. We have also adapted this system to the Wave bioreactor and reliably achieve yields exceeding 1e14 vg/liter at the ten liter scale using a fed batch procedure. We are now working to replicate these production yields using larger volumes. Vectors produced by this process appear equivalent to vectors produced by transfection in several in vitro assays. An in vivo comparison of Factor IX vectors is currently in progress.
Abstract B05: Targeting BRAF and CDK4 in BRAF mutant melanoma induces sustained tumor regression
Authors: Karen E. Sheppard, Cullinane Carleen, Laura Kirby, Kelly Waldeck, Richard Young, Claire Martin, Todd VanArsdale, Sophia Randolph, Grant A. McArthur
Journal: Cancer Research (2015)

Abstract Background: The p16-cyclinD-CDK4-RB1 pathway (CDK4 pathway) is deregulated in 90% of melanomas. The main outcome of CDK4 activation is the phosphorylation and thus, inhibition of RB1 leading to G1–S cell-cycle transition. In addition, CDK4 directly phosphorylates other proteins that promote cell-cycle progression and inhibit both cell senescence and apoptosis. The MAPK/ERK pathway is deregulated in 90% of melanoma and enhances CDK4 pathway signaling through increasing cyclin D1 expression. We have previously demonstrated in a panel of melanoma cell lines that the majority of cell lines were sensitive to a CDK4/6 inhibitor (Palbociclib) and consistent with the concept of CDK4 pathway-dependent oncogene addiction, cell lines with loss of functional p16INK4A were significantly more sensitive to Palbociclib than cells with wild-type p16INK4A. We hypothesized that dual targeting the MAPK/ERK and CDK4 pathways would lead to robust inhibition of the CDK4/Cyclin D complex and consequently induce greater tumor regression than single agent treatment. Results: In vitro, PLX4720, Palbociclib or their combination inhibited BRAF mutant melanoma cell line proliferation and clonogenic survival, however, only with the combination treatment group was a rapid sustained inhibition achieved. Enlarged flattened cells and a significant increase in SA-β-galactosidase staining indicated that the dual treatment resulted in robust cellular senescence. In a BRAFV600E mutant A375 xenograft model, Palbociclib and PLX4720 initially induced tumor regression and tumor stasis respectively, but resistance eventually developed. In contrast, in the combination treatment, tumors regressed and sustained inhibition of tumor growth was maintained. Preliminary biomarker studies indicate resistance to PLX4720 was due to reactivation MAPK/ERK pathway and resistance to Palbociclib to partial restoration of phosphorylated RB1. Conclusions: Combination therapy of MAPK/ERK pathway inhibitors with CDK4 inhibitors is likely to be an effective treatment for BRAF mutant melanoma and in addition delay resistance to single agent targeted therapy. Citation Format: Karen E. Sheppard, Cullinane Carleen, Laura Kirby, Kelly Waldeck, Richard Young, Claire Martin, Todd VanArsdale, Sophia Randolph, Grant A. McArthur. Targeting BRAF and CDK4 in BRAF mutant melanoma induces sustained tumor regression. [abstract]. In: Proceedings of the AACR Special Conference on Advances in Melanoma: From Biology to Therapy; Sep 20-23, 2014; Philadelphia, PA. Philadelphia (PA): AACR; Cancer Res 2015;75(14 Suppl):Abstract nr B05.
Physicians With Opioid Dependence
Authors: C F Ward
Journal: JAMA (2005)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
High prevalence of human herpesvirus type 8 infection in patients with pulmonary tuberculosis in Taiwan
Authors: C.-C. Su, C.-L. Lai, S.-M. Tsao, M.-N. Lin, T.-C. Hsieh, J.-J. Lu, T.-Y. Chu
Journal: Clinical Microbiology and Infection (2014)

Blood samples were collected from 101 untreated pulmonary tuberculosis (TB) patients and 101 age- and sex-matched healthy control subjects. TB patients had lower lymphocyte and a higher monocyte counts than control subjects (p <0.0001 for both). The seropositive rate of human herpesvirus (HHV) type 8 antibody was higher in patients (30/101) than in control subjects (15/101) (p = 0.01). Antibody titres in patients also exceeded those in control subjects (p 0.006). Lymphocyte and monocyte counts between seronegative and seropositive subjects were not different. Four patients were positive for HHV-8 DNA. The study revealed a significantly higher HHV-8 seroprevalence in untreated pulmonary TB patients than in general population.
Abstract 984: The role of TGF-alpha in the resistance to mesothelioma chemotherapy.
Authors: Sathya Neelature Sriramareddy, Fabian Vandermeers, Chrisostome Costa, Céline Mascaux, Arnaud Scherpereel, Philippe Delvenne, Pascale Hubert, Luc L. Willems
Journal: Cancer Research (2013)

Abstract Background. Malignant mesothelioma (MM) is a cancer of the pleura caused mainly by the inhalation of asbestos fibers. The impact of chemotherapy on the outcome of patients with MM is still unclear. We hypothesized that unresponsiveness to chemotherapy is due to inadequate gene expression in tumor cells. We have previously shown that inhibitors of histones deacetylases (such as valproate, VPA) significantly increases the efficacy of compounds used in chemotherapy (Vandermeers et al, 2010, Clinical Cancer Research 15: 2818). A recent clinical trial on relapsing MM patients has shown that VPA in combination with doxorubicin improves response rates and quality of life (Scherpereel et al, 2011, European Respiratory Journal 37:129). Results. To study the mechanisms associated with the response to chemotherapy, we compared two types of cell lines (M14K and H28) characterized by a difference in sensitivity to doxorubicin+VPA. Using Agilent microarrays and RT-qPCR, we observed that the basal expression level of TGFα was higher in "resistant" H28 compared to "sensitive" M14K cells. To evaluate the functional relevance of TGFα, we modulated its expression either by RNA interference or by transfection of a cDNA vector. A decrease of TGFα expression correlated with induction of apoptosis. Inversely, an inhibition of apoptosis occurred when TGFα was over-expressed. As TGFα is the ligand of EGFR, we tested the effect of gefitinib and erlotinib in combination with VPA+doxorubicin. Both EGFR inhibitors increased apoptosis induced by VPA+doxorubicin in H28 chemoresistant cells. Finally, the VPA+doxorubicin+erlotinib regimen prevented tumor growth in two mouse models (ZL34 in SCID and AB12 in Balb/c). Conclusions. Our data demonstrates that TGFα is involved in the chemoresistance to VPA+doxorubicin, a second-line regimen for MM. Although inefficient alone, tyrosine kinase inhibitors synergize to induce apoptosis in chemoresistant cells and prevent tumor growth in mouse models. Citation Format: Sathya Neelature Sriramareddy, Fabian Vandermeers, Chrisostome Costa, Céline Mascaux, Arnaud Scherpereel, Philippe Delvenne, Pascale Hubert, Luc L. Willems. The role of TGF-alpha in the resistance to mesothelioma chemotherapy. [abstract]. In: Proceedings of the 104th Annual Meeting of the American Association for Cancer Research; 2013 Apr 6-10; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2013;73(8 Suppl):Abstract nr 984. doi:10.1158/1538-7445.AM2013-984
Abstract 3985: Differential activation of unfolded protein response in metastatic vs. non-metastatic osteosarcoma cells following hypoxia and chemotherapeutic stress
Authors: Janine Faraj, Pooja Hingorani, Aparna R. Sertil
Journal: Cancer Research (2014)

Abstract Osteosarcoma (OS) is the most common primary tumor of bone and the second highest cause of cancer-related death in the pediatric age group. Despite significant advances in diagnosis and treatment for this cancer, the overall survival has remained static over the past 20 years. This is due to the fact that little is known about the basic science mechanisms of the pathology of human osteosarcoma as well as the mechanisms of inherent drug resistance of OS. In particular lesser still is known regarding the role of tumor microenvironment that govern growth and progression of osteosarcoma in vivo. Recent clinical reports have demonstrated a negative correlation between tumor hypoxia and overall survival in osteosarcoma patients. In addition to the upregulation of HIFs, it has been shown that hypoxia can trigger an adaptive response such as the unfolded protein response (UPR) that allows tumor cells to avoid therapy-induced death. Using in vitro experimental models of both the non-metastatic (SAOS-2) and metastatic (143-b) osteosarcoma cell lines, we now show that hypoxic signaling in these cells differentially activates a pro-survival mechanism via the up-regulation of the endoplasmic reticulum (ER) chaperone BiP and increased activation of the ER stress-activated eukaryotic translation initiator factor 2alpha kinase RNA-dependent protein kinase-like ER kinase (PERK) and ATF-6, markers of UPR allowing the cells to resist drug toxicity. Furthermore RNA interference and dominant-negative expression studies revealed that both ATF-6 and PERK signaling promote survival and drug resistance of OS cells, Our findings shed light on the unknown mechanisms underlying chemotherapeutic drug resistance in osteosarcoma patients. We propose that hypoxic induction of UPR protects OS cells from stress insults, such as chemotherapy. Our research may lead to novel therapies that seek out and destroy the chemoresistant OS cells within the hypoxic core of tumors, thereby preventing survival and metastasis, and ultimately improving the chances of survival amongst OS patients. Citation Format: Janine Faraj, Pooja Hingorani, Aparna R. Sertil. Differential activation of unfolded protein response in metastatic vs. non-metastatic osteosarcoma cells following hypoxia and chemotherapeutic stress. [abstract]. In: Proceedings of the 105th Annual Meeting of the American Association for Cancer Research; 2014 Apr 5-9; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2014;74(19 Suppl):Abstract nr 3985. doi:10.1158/1538-7445.AM2014-3985
Forthcoming theme issues and how we chose them
Authors: T. Delamothe
Journal: BMJ (2001)

Beginning with our theme issue marking the 50th anniversary of the Nuremberg doctors' trial in 1996 we have published 34 theme issues on a wide range of subjects.1 Sometimes these have arisen from an explicit decision to raise the profile of a particular topic; in other cases they seem to have assembled themselves from material that has been sent in unsolicited. Of the infinite number of topics that could have been chosen, the journal's editorial team has had the final say. When it comes to readers' needs we have known best.

Elsewhere in the journal we have been chiselling away at this notion of …