THE THERAPEUTIC RESPONSE OF TUBERCULOUS NEGROES WITH THE SICKLE CELL TRAIT
Authors: W WEISS
Journal: Annals of Internal Medicine (1953)

Article1 March 1953THE THERAPEUTIC RESPONSE OF TUBERCULOUS NEGROES WITH THE SICKLE CELL TRAITWILLIAM WEISS, M.D.WILLIAM WEISS, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-38-3-523 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTuberculosis in the Negro race is more often acute and more often leads to death than in the white race. This is true even when environmental factors are similar in both races.1 Therefore, constitutional factors must be important in the Negro's reaction to tuberculous infection.These constitutional factors are not easily defined and their influence is not readily measured in most cases. However, the sickling phenomenon, which is almost peculiar to the Negro, requires only a simple test to uncover its presence. Since blood supply is important in inflammatory diseases such as tuberculosis, it seems reasonable that sickling of red...Bibliography1. West JB: An inquiry into the importance of the racial factor in the epidemiology of tuberculosis, Supplement to Am. Rev. Tuberc. 41: 114, 1940. Google Scholar2. WeissWaife WSO: Tuberculosis and sickle cell anemia, Am. Rev. Tuberc. 65: 735, 1952. MedlineGoogle Scholar3. LangeMinnichMoore RDVCV: Effect of oxygen tension and of pH on the sickling and mechanical fragility of erythrocytes from patients with sickle cell anemia and the sickle cell trait, J. Lab. and Clin. Med. 37: 789, 1951. MedlineGoogle Scholar4. Wintrobe MM: Clinical hematology, 1942, Lea and Febiger, Philadelphia, p. 467. Google Scholar5. Sturgis CC: Hematology, 1948, C. C. Thomas, Springfield, Ill., p. 329. Google Scholar6. Margolies MP: The incidence of sickling, Am. J. M. Sc. 221: 270, 1951. CrossrefMedlineGoogle Scholar7. WeissStecher WW: Tuberculosis and the sickle cell trait, Arch. Int. Med 89: 914, 1952. CrossrefGoogle Scholar8. GreenConley TWCL: Occurrence of symptoms of sickle cell disease in the absence of persistent anemia, Ann. Int. Med. 34: 849, 1951. LinkGoogle Scholar9. BauerFisher JLJ: Sickle cell disease with special regard to its nonanemic variety, Arch. Surg. 47: 553, 1943. CrossrefGoogle Scholar10. Sullivan BH: Danger of airplane flight to persons with sicklemia, Ann. Int. Med. 32: 338, 1950. LinkGoogle Scholar11. ThompsonWagnerMacLeod RKJACM: Sickle cell disease: report of a case with cerebral manifestations in the absence of anemia, Ann. Int. Med. 29: 921, 1948. LinkGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Philadelphia, Pennsylvania*Presented in part at the Fourteenth Annual Round-up of Eastern Pennsylvanians, American College of Physicians, Philadelphia, January 25, 1952. Received for publication August 5, 1952.From the Department of Chronic Diseases of the Chest, Philadelphia General Hospital, and the Woman's Medical College of Pennsylvania. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byHemopoietic SystemNOTES ON SICKLE-CELL POLYMOKPHISM. 1 March 1953Volume 38, Issue 3Page: 523-527KeywordsBloodRacial and ethnic issuesThorax ePublished: 1 December 2008 Issue Published: 1 March 1953 PDF downloadLoading ...