Nonoliguric Renal Failure and Enflurane
Authors: Michael N. Hartnett, Will Lane, William M. Bennett
Journal: Annals of Internal Medicine (1974)

Letters1 October 1974Nonoliguric Renal Failure and EnfluraneMICHAEL N. HARTNETT, M.D., WILL LANE, M.D., WILLIAM M. BENNETT, M.D.MICHAEL N. HARTNETT, M.D.Search for more papers by this author, WILL LANE, M.D.Search for more papers by this author, WILLIAM M. BENNETT, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-81-4-560 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: Nonoliguric failure is a well-documented complication of anesthesia with the fluorinated hydrocarbon methoxyflurane (1, 2). This nephrotoxicity is related to the dose of inorganic fluoride (2). Although the metabolism of enflurane (Ethrane®*), yields less inorganic fluoride, enflurane has caused renal dysfunction in animals (3). A recent report implicated enflurane in deterioration of renal function in a transplant patient undergoing surgery (4). The following case report may represent a second occurrence and is being communicated to alert internists to potential nephrotoxicity of this anesthetic.A 42-year-old woman was admitted for elective ankle fusion. Known medical problems included chronic...References1. CRANDELLPAPPASMACDONALD WSA: Nephrotoxicity associated with methoxyflurane anesthesia. Anesthesiology 27:591-607, 1966 CrossrefMedlineGoogle Scholar2. COUSINSMAZZE MR: Methoxyflurane nephrotoxicity. A study of dose response in man. JAMA 225:1611-1616, 1973 CrossrefMedlineGoogle Scholar3. BARRCOUSINSMAZZE GMR: A comparison of the renal effects and metabolism of enflurane and methoxyflurane in Fischer 344 rats. J Pharmacol Exp Ther 188:257-264, 1974 MedlineGoogle Scholar4. LOEHNINGMAZZE RR: Possible nephrotoxicity from enflurane in a patient with severe renal disease. Anesthesiology 40:203-205, 1974 CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Division of Nephrology Department of Medicine University of Oregon Medical School Portland, Oregon 97201*Ohio Medical Products, Madison, Wisconsin. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byANESTHESIA FOR RENAL TRANSPLANTATIONEAnaesthesia and Major Surgery in Patients with Renal FailureInhalation anaesthesiaRenal Injury from Chemotherapeutic AgentsAlfentanil as an adjuvant of balanced anaesthesia for tonsillectomy in adultsToxicity of Volatile Anaesthetic AgentsAnaesthesia for patients with chronic renal diseaseDifferent Forms of Ischemic/ Toxic Acute Renal Failure in HumansAnaesthesia and the KidneyAnaesthesia for the Patient with Impaired Renal FunctionEnflurane Hepatotoxicity A Clinicopathologic Study of 24 CasesJAMES H. LEWIS, M.D., HYMAN J. ZIMMERMAN, M.D., KAMAL G. ISHAK, M.D., FLORABEL G. MULLICK, M.D.Die Wirkung von Inhalationsanaesthetika auf die NierenfunktionEffects of Inhalation Anaesthetics on Renal Function A Brief Review with Special Reference to Renal Handling of Fluoride IonsEffects of Inhalation Anaesthetics on Renal Function A Brief Review with Special Reference to Renal Handling of Fluoride IonsVOLATILE ANAESTHETIC METABOLISM AND ACUTE TOXICITYEffects of Renal Function on Serum Fluoride Level in Dogs During and After Enflurane AnesthesiaEnflurane Anesthesia in Living Donor Renal TransplantationSynthesis of deuterated and tritiated derivatives of enfluraneENFLURANE IN CLINICAL PRACTICENeurolept Anaesthesia for the Renal Transplant OperationInvestigation of the mechanism of defluorination of enflurane in rat liver microsomes with specifically deuterated derivativesRenal Function and Fluoride Formation and Excretion During Enflurane AnaesthesiaEffects of Enflurane Anesthesia on the Function of Ischemically Damaged KidneysEnflurane Nephrotoxicity and Pre-Existing Renal DysfunctionGlomerular Filtration Rate during Enflurane Anaesthesia 1 October 1974Volume 81, Issue 4Page: 560-560KeywordsAnesthesiaAnestheticsAnklesHydrocarbonsRenal failureSurgery ePublished: 1 December 2008 Issue Published: 1 October 1974 PDF downloadLoading ...