OCHRONOSIS: REPORT OF TWO CASES
Authors: H P SMITH, H P SMITH
Journal: Annals of Internal Medicine (1955)

Case Reports1 January 1955OCHRONOSIS: REPORT OF TWO CASESHUGH P. SMITH, M.D., F.A.C.P., HUGH P. SMITH JR., M.D.HUGH P. SMITH, M.D., F.A.C.P.Search for more papers by this author, HUGH P. SMITH JR., M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-42-1-171 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptOchronosis is a rare but fascinating metabolic disorder which is sometimes startling for its discoloration of the cartilages, sclerae and other areas. In most well studied cases it seems to be secondary to alkaptonuria, which is usually congenital in origin, and ordinarily seems to be a Mendelian recessive trait, although in some families it has been transmitted as a dominant characteristic.1, 2In addition, there have been cases reported secondary to prolonged exposure to carbolic acid,3particularly when it was used as a continuous moist dressing for a chronic cutaneous ulcer. Since this custom has practically disappeared, nearly all cases...Bibliography1. HogbenWorrallZieve LRLI quoted by Hall, W. K., Hawkins, K. R., and Child, G. P.: The inheritance of alkaptonuria in a large American family, J. Hered. 41: 23-25 (Jan.) 1950. CrossrefGoogle Scholar2. MilchMilch HRA: Alkaptonuria, J. Internat. Coll. Surgeons 15: 669-685 (June) 1951. MedlineGoogle Scholar3. Beddard AP: Ochronosis associated with carboluria, Quart. J. Med. 3: 329-336 (July) 1910. Google Scholar4. SutroAnderson CJME: Alkaptonuric arthritis, Surgery 22: 120-124 (July) 1947. MedlineGoogle Scholar5. PomeranzFriedmanTunick MMLJIS: Roentgen findings in alkaptonuric ochronosis, Radiology 37: 295-303 (Sept.) 1941. CrossrefGoogle Scholar6. Pugh DG: Ochronosis, in Diagnostic roentgenology, ed. by Ross Golden, 1952, The Williams and Wilkins Co., Baltimore, pp. 553-555. Google Scholar7. CoodleyGreco ELAJ: Clinical aspects of ochronosis, with report of a case, Am. J. Med. 8: 816-822 (June) 1950. CrossrefGoogle Scholar8. GaldstonSteeleDobriner MJMK: Alcaptonuria and ochronosis, with a report of three patients and metabolic studies in two, Am. J. Med. 13: 432-452 (Oct.) 1952. CrossrefMedlineGoogle Scholar9. Young HH: Calculi of the prostate associated with ochronosis and alkaptonuria, J. Urol. 51: 48-58 (Jan.) 1944. CrossrefGoogle Scholar10. Bauer O, quoted by Young.9 Google Scholar11. MartinUnderdahlMathieson WJLODR: Alkaptonuria: report of 3 cases, Proc. Staff Meet., Mayo Clin. 27: 193-200 (May 7) 1952. MedlineGoogle Scholar12. Skinsnes OK: Generalized ochronosis: report of an instance in which it was misdiagnosed as melanosarcoma, with resultant enucleation of an eye, Arch. Path. 45: 552-558 (Apr.) 1948. Google Scholar13. Smith JW: Ochronosis of the sclera and cornea complicating alkaptonuria, review of the literature and report of four cases, J. A. M. A. 120: 1282-1288 (Dec. 19) 1942. CrossrefGoogle Scholar14. Fishberg EH: The instantaneous diagnosis of alkaptonuria on a single drop of urine, J. A. M. A. 199: 882 (July 11) 1942. CrossrefGoogle Scholar15. Eisenberg H: Alkaptonuria, ochronosis, arthritis and ruptured intervertebral disk, complicated by homologous serum reaction, Arch. Int. Med. 86: 79-86 (July) 1950. CrossrefGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Greenville, South Carolina*Received for publication March 31, 1954. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byDisorders of phenylalanine and tyrosine metabolismMutation spectrum of homogentisic acid oxidase ( HGD ) in alkaptonuriaHeritable Disorders of Connective TissueCoronary Artery Disease in ChildrenHereditary multiple exostoses with spinal cord compression.Etiology and prevention of coronary obstructive lesions in infancy and childhoodCardiac manifestations of ochronosisCardiac involvement in inherited disorders of metabolismUrolithiasis and prostatolithiasis in alcaptonuria with ochronosisRöntgendiagnostik der Muskeln, Sehnen und Bänder Pathologische Verdichtungen und Aufhellungen im WeichteilmantelAlkaptonuria and Ochronotic ArthropathyBiochemical, pathologic and clinical aspects of alcaptonuria, ochronosis and ochronotic arthropathyRHEUMATISM AND ARTHRITIS: REVIEW OF AMERICAN AND ENGLISH LITERATURE OF RECENT YEARS (TWELFTH RHEUMATISM REVIEW)* Part IICHARLEY J. SMYTH, M.D., F.A.C.P., JOSEPH J. BUNIM, M.D., F.A.C.P., WILLIAM S. CLARK, M.D., F.A.C.P., DARRELL C. CRAIN, M.D., F.A.C.P., FELIX E. DEMARTINI, M.D., IVAN F. DUFF, M.D., F.A.C.P., EPHRAIM P. ENGLEMAN, M.D., F.A.C.P., DONALD C. GRAHAM, M.D., F.R.C.P. (C), MAX M. MONTGOMERY, M.D., F.A.C.P., BERNARD M. NORCROSS, M.D., F.A.C.P., HOWARD F. POLLEY, MARIAN W. ROPES, M.D., F.A.C.P., EDWARD F. ROSENBERG, M.D., F.A.C.P.Alkaptonuria. Report of a family with seven cases appearing in four successive generations, with metabolic studies in one patient 1 January 1955Volume 42, Issue 1Page: 171-178KeywordsCartilageMetabolic disordersUlcers Issue Published: 1 January 1955 PDF downloadLoading ...