tbuckley/cabot-search huggingface dataset:
Fatigue and plasma tryptophan levels in patients on chronic hemodialysis
Authors: Maurizio Bossola, Luigi Tazza
Journal: Kidney International (2015)

To the Editor: Mutsaers et al.1Mutsaers H.A. Masereeuw R. Olinga P. Altered tryptophan metabolism and CKD-associated fatigue.Kidney Int. 2014; 86: 1061-1062Abstract Full Text Full Text PDF PubMed Scopus (11) Google Scholar have recently suggested that there is a direct link between tryptophan metabolism and the circadian rhythm in patients with chronic kidney disease (CKD) and that altered tryptophan metabolism as etiology for CKD-associated fatigue warrants further investigation. We have recently measured, by liquid chromatography with fluorometric detection previously described,2Bossola M. Scribano D. Colacicco L. et al.Anorexia and plasma levels of free tryptophan, branched chain amino acids, and ghrelin in hemodialysis patients.J Ren Nutr. 2009; 19: 248-255Abstract Full Text Full Text PDF PubMed Scopus (21) Google Scholar plasma free tryptophan (FTRP) levels, large neutral amino-acid (LNAA) levels, and the FTRP/LNAA ratio in 50 patients on chronic hemodialysis and correlated with fatigue assessed through the SF-36 Vitality subscale.3Mingardi G. Cornalba L. Cortinovis E. et al.Health-related quality of life in dialysis patients: a report from an Italian study using the SF-36 Health Survey: DIA-QOL Group.Nephrol Dial Transplant. 1999; 14: 1503-1510Crossref PubMed Scopus (172) Google Scholar Patients were divided into two groups, fatigued (SF-36 Vitality subscale score ≤50) and not-fatigued (SF-36 Vitality subscale score ≤50).4Collado-Hidalgo A. Bower J.E. Ganz P.A. et al.Inflammatory biomarkers for persistent fatigue in breast cancer survivors.Clin Cancer Res. 2008; 12: 2759-2766Crossref Scopus (307) Google Scholar The two groups were similar for age, sex, primary cause of end-stage renal disease, body mass index, dialytic age, serum albumin, creatinine, and urea. As shown in the Table 1, the two groups did not differ significantly for the plasma levels of FTRP, LNAA, and FTRP/LNAA ratio. In addition, the correlation between fatigue and FTRP (correlation coefficient: -0.001; P=0.999), LNAA (-0.072; P=0.606), and FTRP/LNAA ratio (0.035; P=0804) was not statistically significant.Table 1Fatigue and plasma levels of FTRP and other LNAA in fatigue and not-fatigued patients (large neutral amino-acids)Fatigued (n=25)Not-fatigued (n=25)PFTRP (nmol/ml)15.2±7.714.6±12.60.839LNAA (nmol/ml)529±163533±1070.918FTRP/LNAA0.029±0.0140.026±0.0210.551Abbreviations: FTRP, plasma free tryptophan; LNAA, large neutral amino-acids.It seems that there is no correlation between fatigue and plasma tryptophan levels in patients on chronic hemodialysis. Open table in a new tab Abbreviations: FTRP, plasma free tryptophan; LNAA, large neutral amino-acids. It seems that there is no correlation between fatigue and plasma tryptophan levels in patients on chronic hemodialysis.
Appropriate Care of a Swollen Joint—Reply
Authors: Abi Vijenthira, Amanda E. Goldberg, Brian M. Wong
Journal: JAMA Internal Medicine (2015)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Internal Medicine HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Internal Medicine journal
Porphyria cutanea tarda and glucose metabolism alterations: reply from authors
Authors: C. Muñoz-Santos, A. Guilabert, C. Herrero
Journal: British Journal of Dermatology (2011)

Journal Article Porphyria cutanea tarda and glucose metabolism alterations: reply from authors Get access C. Muñoz‐Santos, C. Muñoz‐Santos Department of Dermatology, Hospital Clinic Universitat de Barcelona 170 Villarroel 08036 Barcelona, Spain E‐mail: carlosmunozsantos@gmail.com Search for other works by this author on: Oxford Academic Google Scholar A. Guilabert, A. Guilabert Department of Dermatology, Hospital Clinic Universitat de Barcelona 170 Villarroel 08036 Barcelona, Spain E‐mail: carlosmunozsantos@gmail.com Search for other works by this author on: Oxford Academic Google Scholar C. Herrero C. Herrero Department of Dermatology, Hospital Clinic Universitat de Barcelona 170 Villarroel 08036 Barcelona, Spain E‐mail: carlosmunozsantos@gmail.com Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 165, Issue 6, 1 December 2011, Pages 1363–1364, https://doi.org/10.1111/j.1365-2133.2011.10619.x Published: 01 December 2011
Autoimmunity Resulting From Cytokine Treatment Predicts Long-Term Survival in Patients With Metastatic Renal Cell Cancer
Authors: Anke Franzke, Dietrich Peest, Michael Probst-Kepper, Jan Buer, Gabriele I. Kirchner, Georg Brabant, Hartmut Kirchner, Arnold Ganser, Jens Atzpodien
Journal: Journal of Clinical Oncology (1999)

PURPOSE: In patients undergoing cytokine therapy, systemically applied interleukin-2 (IL-2) and/or interferon-alpha (IFN-α) have been reported to induce thyroid dysfunction as well as thyroid autoantibodies. We analyzed the correlation of thyroid autoimmunity with HLA phenotype, various other autoimmune parameters, and patient survival. PATIENTS AND METHODS: For this purpose, antithyroglobulin autoantibodies, antimicrosomal thyroid autoantibodies, thyroglobulin receptor autoantibodies, thyroid dysfunction, and multiple clinical parameters were determined in 329 unselected patients with metastatic renal cell cancer before and after systemic IL-2 and IFN-α2 therapy. For statistical analysis, we used both univariate and multivariate Cox proportional hazards models and the two-tailed Fisher's exact test. RESULTS: Antithyroglobulin autoantibodies and antimicrosomal thyroid autoantibodies were detected in 60 patients (18%); positive autoantibody titers of various other autoimmune parameters were statistically unrelated. The presence of thyroid autoantibodies was correlated with prolonged survival (P &lt; .0001). There was a statistically significant difference in frequencies of HLA-Cw7 expression between thyroid autoantibody-positive and -negative patients (P ≤ .05), and the Cw7 expression was associated with prolonged overall survival (P = .009). CONCLUSION: The evaluation of thyroid autoantibodies during cytokine therapy could be a useful prognostic marker for patients with renal cell carcinoma who benefit from cytokine treatment. IL-2– and IFN-α2-induced tumor control and prolonged survival may require breaking of immunologic tolerance against self-antigens.
Second cancer risk in hairy cell leukemia: analysis of 350 patients.
Authors: R Kurzrock, S S Strom, E Estey, S O'Brien, M J Keating, H Jiang, T Adams, M Talpaz
Journal: Journal of Clinical Oncology (1997)

PURPOSE The discovery of effective therapy for hairy cell leukemia (HCL) has increased the relevance of long-term outcome. We have therefore examined the incidence of second cancers. PATIENTS AND METHODS Data on 350 HCL patients was obtained from the M.D. Anderson Cancer Center Cancer Registry's computerized data base and from chart review. Standardized incidence ratios (SIRs) and standardized mortality ratios (SMRs) (observed/expected [O/E]) were calculated with the expected number determined using age, sex, and calendar-year-specific rates from the Connecticut Tumor Registry and from national mortality data, respectively. RESULTS The median age of the patients was 50 years and the median follow-up duration was 6 years. Twenty-six patients developed a second cancer at least 6 months after the HCL diagnosis (O/E ratio, 1.34; P = .08). There was no excess of malignancy among patients treated with interferon alfa (IFN-alpha; P = .27), 2-chlorodeoxyadenosine (2CDA; P = .37), or deoxycoformycin (DCF; P = .7). However, an excess of myeloma-related neoplasms (O/E, 13.04; P &lt; .001) and lymphomas (O/E, 8.7; P = .03) was observed. Survival from the advent of systemic therapy for HCL was better than before this time (P = .0009). Nevertheless, mortality remained excessive (O/E, 6.17; P &lt; .001), mainly because of HCL-related infections and secondary malignancy. CONCLUSION Among 350 patients with HCL, there was an increase in the number of second cancers; however, it did not reach statistical significance and was not associated with therapy. The incidence of lymphoid neoplasms was significantly higher than expected. Survival since the advent of effective systemic therapy was excellent, although excess mortality was still observed.
Serum vitamin D, physical activity and the obstructive sleep apnea syndrome
Authors: Conor P. Kerley, Liam J. Cormican, John L. Faul, Ashling McGown, Katrina Hutchinson
Journal: European Respiratory Journal (2012)

Introduction: Obstructive sleep apnea syndrome (OSAS) and vitamin D deficiency (VDD) are common conditions associated with excess adiposity and physical inactivity. Data on OSA, VDD and physical activity is lacking.  Aims & objectives: We hypothesized that OSAS patients might have low levels of vitamin D and that this may be related to physical activity and body composition.  Methods: Untreated subjects recently diagnosed with OSAS by nocturnal polysomnography gave informed consent. Weight, height and neck circumference were measured using standard protocols. The Diasorin assay was used to quantify 25-hydroxy-vitamin D (25OH)D) levels. The SenseWear® armband (SWA) was used to assess free-living physical activity.  Results: 37 individuals (25 male, 12 female; mean age = 52; mean BMI = 36.3kg/m2) completed the evaluation. No participant had sufficient vitamin D (>80nmol/L). Subjects with severe OSA had higher body mass index (BMI) (p  90% wear time). Mean steps/day = 7,110 (6,710–25,454). Mean sedentary time = 21h7m (16h2m-23h32m).  Conclusions: Among this sample, activity levels were low and adiposity was high. Lifestyle intervention should be encouraged for all overweight, sedentary OSAS cases. Consideration of hypovitaminosis D among OSAS cases is warranted, though its clinical significance is as of yet unclear.  References:  1. Hollis BW. J Nutr. 2005 Feb;135(2):317-22.  2. Dawson-Hughes B et al. Osteoporos Int. 2005 Jul;16(7):713-6.
Glycoprotein Degradation in the Blind Loop Syndrome
Authors: Roberto Prizont
Journal: Journal of Clinical Investigation (1981)

Contents obtained from jejunum of normal controls, self-emptying and self-filling blind loop rats were analyzed for the presence of glycoprotein-degrading glycosidases. The blind loop syndrome was documented by the increased fat excretion and slower growth rate of self-filling blind loop rats 6 wk after surgery. With p-nitrophenylglycosides as substrate, the specific activity of α-N-acetylgalactosaminidase, a potential blood group A destroying glycosidase, was 0.90±0.40 mU/mg of protein. This level was 23-fold higher than the specific activity of normal controls. In partially purified self-filling blind loop contents, the activity of α-N-acetylgalactosaminidase was 9- to 70-fold higher than activities of self-emptying and normal controls. Antibiotic treatment with chloromycetin and polymyxin decreased 24-fold the glycosidase levels in self-filling blind loops. In experiments with natural substrate, the blood group A titer of a20,000g supernate from normal jejunal homogenates decreased 128-fold after 24-h incubation with blind loop contents. Normal contents failed to diminish the blood group reactivity of the natural substrate. Furthermore, blind loop contents markedly decreased the blood group A titer of isolated brush borders. Incubation between blind loop bacteria and mucosal homogenates or isolated brush borders labeled with d-[U-14C]glucosamine revealed increased production of labeled ether extractable organic acids. Likewise, intraperitoneal injection of d-[U-14C]glucosamine into self-filling blind loop rats resulted in incorporation of the label into luminal short chain fatty acids. These results suggest that glycosidases may provide a mechanism by which blind loop bacteria obtain sugars from intestinal glycoproteins. The released sugars are used and converted by bacteria into energy and organic acids. This use of the host's glycoproteins would allow blind loop bacteria to grow and survive within the lumen independent of exogenous sources.
Consistency of sternal percussion performed manually and with mechanical thumper
Authors: AB Bohadana, SS Kraman
Journal: European Respiratory Journal (1992)

Auscultatory percussion is a technique that is potentially useful to study the acoustic behaviour of the chest. However, finger percussion, as used in this technique, has not been previously assessed for consistency. We calculated the intrasubject variability and short-term reproducibility of this technique in 10 healthy subjects. We examined several indices of the output sound of two series of sternal percussion manoeuvres performed one hour apart by the same examiner. The results were compared to those obtained during sternal percussion performed by a mechanical thumper. Consistency for both finger and thumper percussion varied from 4.8-20.6 (coefficients of variation) for various acoustic indices. For thumper percussion, the average results were not significantly different from those of finger percussion. We conclude that finger percussion of the sternum is sufficiently consistent to be used as a tool to investigate the acoustic behaviour of the chest.
Clinicopathological prognostic factors in operated for pulmonary carcinoid tumor patients
Authors: Dora Marinova, Yanina Slavova, Plamen Titorenkov, Dimitar Kostadinov, Maja Tafradjiiska, Eluar Goranov, Danail Petrov
Journal: European Respiratory Journal (2014)

Aim:to study the prognostic significance of N-status,pTNM stage,EGFR (Epidermal Growth Factor Receptor), mTOR(phosphorilated on Ser2442)(mamalian Target Of Rapamycin) protein expression and p70S6 kinase(phosphorilated on Ser411)expression in operated for pulmonary carcinoid tumor patients.  Material and methods:Surgically resected specimen (men n=35;women n=42, mean age 48.5±13) from 64typical carcinoid(TC) and 13atypical carcinoid(AtC) patients were studied. The N-status(N0 n=68;N1/2 n=9),pTNM stage(I n=57; II n=13;III n=7) and immunohistochemical expression of EGFR (positive n=16/negative n=61), mTOR(positive n=34/negative n=43) and p70S6(>90% n=61/≤90% n=16)were evaluated.Statistical methods used:Kaplan-Meier,Wilcoxon,Cox regression analyses.  Results:The 5 year survival for TCs was 88% and for AtCs–74%.The difference in mean survival time between TCs (125 months) and AtCs (72 months) was not significant(p=0.24).11% of the TCs were in N1/2 status and 15% of the AtCs were in N1/2 status. The 5 year survival for N0 was 89% and for N1/2–63% (p=0.085).The mean survival time was significantly longer in N0 status(N0-129 months,N1/2-87,p=0.005),in I and II pTNM status(I/II-125 months,III-38,p=0.005),in cases negative forEGFR (negative-128 months,positive-84,p=0.030), and in cases positive for mTOR (p=0.035). The Cox analysis confirmed the prognostic significance of N status(Hazard ratio[HR]5.25;p=0.012),pTNM stage(HR 14.14;p=0.019)and EGFR expression(HR 3.78;p=0.047).  Conclusions:N0-status,pTNM I/II stage, lack of EGFRexpression and positive mTOR expression may represent favorable prognostic factors in pulmonary carcinoid tumors.
The Power of Advanced Capability and Informed Policy
Authors: Todd E. Rasmussen
Journal: JAMA Surgery (2015)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Surgery HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Surgery journal
Phase I Multicentre Tax-Torc Trial of the Dual Mtorc1/2 Inhibitor Azd2014 (A) Plus Weekly Paclitaxel (P) in Patients (Pts) with Solid Tumours (Crukd/12/013)
Authors: B. Basu, D. Roda-Perez, H.H. Wong, N. Sathiyayogan, M. Parmar, A. Turner, K. Swales, S. Stimpson, E. Hall, M. Hategan, J. Garcia-Corbacho, T.A. Yap, L.R. Molife, B. Jimenez, S. Banerjee, S.B. Kaye, J.S. De Bono, U. Banerji
Journal: Annals of Oncology (2014)
The cultivable human oral gluten-degrading microbiome and its potential implications in coeliac disease and gluten sensitivity
Authors: M. Fernandez-Feo, G. Wei, G. Blumenkranz, F.E. Dewhirst, D. Schuppan, F.G. Oppenheim, E.J. Helmerhorst
Journal: Clinical Microbiology and Infection (2013)

Coeliac disease is characterized by intestinal inflammation caused by gluten, proteins which are widely contained in the Western diet. Mammalian digestive enzymes are only partly capable of cleaving gluten, and fragments remain that induce toxic responses in patients with coeliac disease. We found that the oral microbiome is a novel and rich source of gluten-degrading organisms. Here we report on the isolation and characterization of the cultivable resident oral microbes that are capable of cleaving gluten, with special emphasis on the immunogenic domains. Bacteria were obtained by a selective culturing approach and enzyme activities were characterized by: (i) hydrolysis of paranitroanilide-derivatized gliadin-derived tripeptide substrates; (ii) gliadin degradation in-gel (gliadin zymography); (iii) gliadin degradation in solution; (iv) proteolysis of the highly immunogenic α-gliadin-derived 33-mer peptide. For selected strains pH activity profiles were determined. The culturing strategy yielded 87 aerobic and 63 anaerobic strains. Species with activity in at least two of the four assays were typed as: Rothia mucilaginosa HOT-681, Rothia aeria HOT-188, Actinomyces odontolyticus HOT-701, Streptococcus mitis HOT-677, Streptococcus sp. HOT-071, Neisseria mucosa HOT-682 and Capnocytophaga sputigena HOT-775, with Rothia species being active in all four assays. Cleavage specificities and substrate preferences differed among the strains identified. The approximate molecular weights of the enzymes were ~75 kD (Rothia spp.), ~60 kD (A. odontolyticus) and ~150 kD (Streptococcus spp.). In conclusion, this study identified new gluten-degrading microorganisms in the upper gastrointestinal tract. A cocktail of the most active oral bacteria, or their isolated enzymes, may offer promising new treatment modalities for coeliac disease.
The effect of anticholinergic and beta-agonist pretreatment on bronchoconstriction induced by N-formyl-methionyl-leucyl-phenylalanine
Authors: MJ Peters, AB Breslin, N Berend
Journal: European Respiratory Journal (1989)

N-Formyl-methionyl-leucyl-phenylalanine (FMLP), an acylated tripeptide bacterial neutrophil chemotactic factor, has been shown to be a bronchoconstrictor by inhalation in man in vivo. It thus has a putative role in the generation of bronchoconstriction associated with bacterial bronchial infection. We have investigated the effect of pretreatment with the anticholinergic agent, ipratropium bromide (IB), and the beta 2-agonist, fenoterol (F), on FMLP-induced bronchoconstriction. Ten non-asthmatic subjects aged 21-28 yrs performed dose-response curves to nebulized FMLP on 3 study days after pretreatment with saline, F or IB. Amongst the 8 subjects who bronchoconstricted by 20% to FMLP there was a significant increase in the provocative concentration causing a 20% fall in forced expiratory volume in one second (FEV1) (PC20FMLP) after both IB and F. F was significantly better than IB. When comparison was made using absolute fall in FEV1 and including all 10 subjects the same results were found. Partial inhibition of FMLP-induced bronchoconstriction by IB suggests that part of the effect of FMLP is vagally mediated. We suggest that F is acting via modulation of FMLP-induced rises in intracellular free calcium.
The Feasibility of Folfox Therapy on Non-Hemodialysis Days for Hemodialysis Patients with Colorectal Cancer
Authors: Taichi Murai, Michio Nakamura, Taku Shigesawa, Yuta Koike, Yomo Fujita, Ayana Endo, Yuji Ono, Toshihiko Kudo, Atsushi Nagasaka, Shuji Nishikawa
Journal: Annals of Oncology (2014)
William Mackie Buchanan
Authors: N. B. R. F. S. Orr
Journal: BMJ (2015)

William Mackie Buchanan (“Bill”) had just embarked on his first ship in Glasgow, as a navigating cadet, when war was declared in 1939. He would survive his ship sinking, off Cape Town, in a collision owing to fog; a later vessel was the last to leave Rangoon immediately before Japanese occupation. After the war he studied medicine in Glasgow and joined the …
Airway resistance during the methacholine challenge test: Comparison between impulse oscillometry and plethysmographic technique
Authors: Egidio Beretta, Francesco Tana, Andrea Aliverti, Luca Novelli, Gabriele Simone Grasso, Giuseppe Miserocchi
Journal: European Respiratory Journal (2011)

Background: Plethysmographic airway resistance (Raw) does not allow identification of bronchoconstriction sites. Conversely, respiratory system resistance (Rrs) measured by impulse oscillometry (IOS) can distinguish between changes in peripheral and central airways mechanics (< 5Hz for peripheral and 5-20 Hz for central airways).We wish to compare Raw to Rrs in response to methacholine challange (MCh).

Methods: 18 subjects underwent saline aerosol bolus (baseline) followed by increasing methacholine doses inhalation. At each dose, Raw and Rrs were measured respectively by body plethysmography and IOS. The measurements were repeated until reaching PD20 (estimated from FEV1) or the maximal dose (2400 μg). We considered subjects with PD20 < 800γ.

Results: Raw increased in all subjects during MCh. In 67% of subjects (group 1) Rrs increased at 1Hz only, while in 33% (group 2) an increase in Rrs was found at all frequencies. In group 1, unlike in group 2, the goodness of the regression between Rrs and Raw (as from R2) was highest at 1Hz, waning progressively with increasing impulse frequency.

View this table:

Rrs vs Raw





Conclusions: Measurements of Rrs in the range 1-20 Hz allow to identify different sites for MCh response. The significant correlation between Rrs at 1Hz and Raw in group 1 suggests that variation in Raw mostly reflects changes in small airways mechanics. In group 2 the significance of the regressions between Rrs at all frequencies and Raw suggests that changes in airways mechanics of various calipers impact on plethysmographic measurements.