TREATMENT OF PNEUMOCOCCAL MENINGITIS WITH SULFADIAZINE AND INTRATHECAL PENICILLIN G WITH RECOVERY
Authors: G S BARNET
Journal: Annals of Internal Medicine (1948)

Case Reports1 March 1948TREATMENT OF PNEUMOCOCCAL MENINGITIS WITH SULFADIAZINE AND INTRATHECAL PENICILLIN G WITH RECOVERYGARFIELD S. BARNET, M.D.GARFIELD S. BARNET, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-28-3-642 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptPrior to the advent of chemotherapy, pneumococcal meningitis carried mortality of almost 100 per cent.1, 7 Sulfonamides lowered this depressing figure to some extent.3 Recent minimum mortality figures representing the results of combined sulfonamide and penicillin therapy approximate 40 per cent.4The present case report was deemed worthwhile because of the following features:(1) The progression of meningitis during the administration of intramuscular and intravenous penicillin.(2) The exclusive use of crystalline penicillin G for intrathecal administration in concentrated solution without adverse reaction.CASE REPORTA 23 year old married colored laborer noted the onset of headache, fever, vomiting, and...Bibliography1. SIEGAL S: Transverse myelopathy following recovery from pneumococcic meningitis, Jr. Am. Med. Assoc., 1945, cxxix, 547-550. CrossrefGoogle Scholar2. JEPSONWHITTY RPCW: Treatment of pneumococcic meningitis, Lancet, 1946, i, 228-232. CrossrefGoogle Scholar3. BRAINERDBRADLEY HE: Treatment of bacterial meningitis with penicillin, sulfonamides, and sera, Calif. Med., 1947, lxvi, 57-61. Google Scholar4. ROMANSKY MJ: The current status of penicillin therapy, Vet. Admin. Tech. Bull., 10-25, 1947, 1-13. Google Scholar5. PRICEHODGES AHJH: The treatment of meningitis with penicillin injected intravenously and intramuscularly, New York State Med. Jr., 1944, xliv, 2012-2014. Google Scholar6. SMITHDUTHIECAIRNS HVESH: Chemotherapy of pneumococcal meningitis, Lancet, 1946, i, 185-193. CrossrefGoogle Scholar7. APPELBAUMNELSON EJ: Penicillin in the treatment of pneumococcic meningitis, Jr. Am. Med. Assoc., 1945, cxxviii, 778-781. CrossrefGoogle Scholar8. COOKEGOLDRING JVD: The concentration of penicillin in various body fluids during penicillin therapy, Jr. Am. Med. Assoc., 1945, cxxvii, 80-87. CrossrefGoogle Scholar9. SWEETDUMOFFDOWLINGLEPPER LKSEHFMH: The treatment of pneumococcic meningitis with penicillin, Jr. Am. Med. Assoc., 1945, cxxvii, 263-267. CrossrefGoogle Scholar10. JOHNSONWALKER HCEH: Intraventricular penicillin, Jr. Am. Med. Assoc., 1945, cxxvii, 217-219. CrossrefGoogle Scholar11. SWEENEYLESLIE JSJT: Pneumococcic meningitis successfully treated with penicillin and sulfadiazine, Ann. Int. Med., 1946, xxiv, 705-707. Google Scholar12. ROTMAN-KAVKAHIRSHDOWLING GHLHF: A comparative study of penicillins X and G and crystalline penicillin G, New Eng. Jr. Med., 1947, ccxxxvi, 314-318. CrossrefGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Aspinwall, Pennsylvania*Received for publication August 15, 1947.Published with permission of the Chief Medical Director, Department of Medicine and Surgery, Veterans Administration, who assumes no responsibility for the opinions expressed or conclusions drawn by the author.†Resident, Internal Medicine. The resident training program at the Veterans Administration Hospital, Aspinwall, Pa., is under the supervision of the Dean's Committee, School of Medicine, University of Pittsburgh. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byIntra-cerebrospinal fluid antibiotics to treat central nervous system infections: A review and update 1 March 1948Volume 28, Issue 3Page: 642-647KeywordsChemotherapyFeversHeadachesHospital medicineMeningitisMortalityPenicillinSulfonamideSurgeryVomiting Issue Published: 1 March 1948 PDF downloadLoading ...