tbuckley/cabot-search huggingface dataset:
628. An Oncolytic Adenovirus Armed with a GM-CSF Activating Designed Zinc-Finger Protein Transcription Factor: A Potential Cancer Vaccine Approach
Authors: Andreas Reik, Philip D. Gregory, Casey C. Case
Journal: Molecular Therapy (2004)

Granulocyte macrophage colony stimulating factor (GM-CSF) is a potent activator of the immune system shown to enhance anti-tumor immune responses. We are inserting engineered zinc-finger protein transcription factors (ZFP TFs) up-regulating the expression of GM-CSF, into selectively-replicating oncolytic viral vectors, such as ONYX-411, in order to render them capable of acting as in vivo  vaccines. In this system replication-dependent expression of the encoded ZFP TF transgene restricts expression to the appropriate cancer cells, while viral replication in these tumor cells results in local gene amplification and spread. GM-CSF secretion by infected tumor cells should stimulate an immune response against the tumor-specific antigens generated by the oncolytic action of the virus. This in turn is predicted to prime the immune system to direct the systemic elimination of tumor cells not reached by the armed therapeutic virus itself and thereby enhance its therapeutic efficiency.
UK Licenses Human Embryo Creation
Authors: Brian Vastag
Journal: JAMA (2003)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Hypercoagulability panel testing predicts thrombosis in neonates undergoing cardiac surgery
Authors: Sirisha Emani, David Zurakowski, Christopher W. Baird, Frank A. Pigula, Cameron Trenor, Sitaram M. Emani
Journal: American Journal of Hematology (2013)

Thrombosis contributes to morbidity and mortality in neonates following cardiac surgery. Alterations in hemostatic factors following cardiac surgery have been described, but there is no data correlating these changes with risk of thrombosis in neonates. The aim of this study is to predict thrombosis in neonates undergoing cardiac surgery by assessment of a panel of hypercoagulability markers. Neonates undergoing cardiac surgery were enrolled preoperatively and prospectively followed. Preoperative hypercoagulability panel testing included thrombin generation assay (TGA), immunoassays for antithrombin III, protein C, protein S, factor VIII, thrombin-activatable fibrinolytic inhibitor (TAFI), plasminogen activator inhibitor-1 (PAI-1), and cardiolipin antibody. Postoperative thrombosis was defined by clinical events (shunt thrombosis, limb ischemia, and stroke) or imaging (intravascular or intracardiac thrombus). Risk factors for thrombosis were assessed. One hundred neonates were enrolled in the study over a two-year period. The incidence of postoperative in-hospital thrombosis was 20%. The only significant clinical risk factor associated with thrombosis was the single ventricle physiology. Hypercoagulability factors associated with increased risk of thrombosis by univariate analysis were elevated PAI-1, TAFI, and TGA, and presence of anticardiolipin antibodies. Multivariable logistic regression analysis demonstrated that elevated PAI-1 (P = 0.015), TAFI (P = 0.028), and TGA (P = 0.007) were independent predictors of thrombosis. Hypercoagulability panel testing may help identify neonates at high risk for thrombosis following cardiac surgery. Future studies are warranted to determine if high risk patients benefit from targeted anticoagulation therapies.
Cost Effectiveness of Paclitaxel-Eluting Stents for Patients Undergoing Percutaneous Coronary Revascularization
Authors: Ameet Bakhai, Gregg W. Stone, Elizabeth Mahoney, Tara A. Lavelle, Chunxue Shi, Ronna H. Berezin, Betsy J. Lahue, Mary Ann Clark, Michael J. Lacey, Mary E. Russell, Stephen G. Ellis, James B. Hermiller, David A. Cox, David J. Cohen
Journal: Journal of the American College of Cardiology (2006)
Late Spring or Summer Hay-Fever in the District of Columbia and Vicinity
Authors: Grafton Tyler Brown
Journal: Annals of Internal Medicine (1927)

Article1 September 1927Late Spring or Summer Hay-Fever in the District of Columbia and VicinityGRAFTON TYLER BROWN, B.S., M.D., F.A.C.P.GRAFTON TYLER BROWN, B.S., M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-1-3-169 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThere are three distinct types of seasonal hay-fever in the District of Columbia and vicinity, namely: early spring, due to tree pollens; late spring or summer, the type under consideration; and the fall variety, due to the pollen of the ragweeds. From a careful analysis of the case records of all the seasonal hay-fever patients who consulted me during the past year, I would estimate that in the District of Columbia and vicinity, the late spring or summer cases are about eight times as frequent as the early spring type, but only half as frequent as the fall variety. About...References(1) BROWN GT: Bacterial Vaccines in Asthma, Am. J. M. Sc. 171:94 (Jan.) 1926. CrossrefGoogle Scholar(2) WALKER IC: Frequent Causes and the Treatment of Seasonal Hay-Fever, Arch. Int. Med. 28:71 (July) 1921. CrossrefGoogle Scholar(3) CLOCK RO: Comparative Value of the Methods of Preparing Pollen Antigen, J. Infect. Dis. 21:523 (Dec.) 1917. CrossrefGoogle Scholar(4) ARMSTRONGHARRISON CWT: A Study of Ragweed Pollen Extracts for Use in the Treatment of Ragweed Pollen Hypersensitiveness, Pub. Health Rep. 39:2422 (Sept. 19) 1924. CrossrefGoogle Scholar(5) NOON L: Lancet 180:1572, 1911. CrossrefGoogle Scholar(6) SCHEPPEGRELL W: Hayfever and Asthma, Lea & Febiger, 1922. Google Scholar(7) BROWN GT: The Co-Seasonal Treatment of Fall Hay-Fever: Report of Cases, Ann. Clin. Med. 3:494 (Jan.) 1925. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Washington, D.C.*Read before the American Therapeutic Society, May 14, 1927. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byAllergic Rhinitis. 1. Vasomotor Rhinitis. Historic Survey. Various Theories and Treatments 1 September 1927Volume 1, Issue 3Page: 169-178KeywordsFallsPollen ePublished: 1 December 2008 Issue Published: 1 September 1927 PDF downloadLoading ...
Paracetamol (acetaminophen) poisoning
Authors: P Routledge, J A Vale, D N Bateman, G D Johnston, A Jones, A Judd, S Thomas, G Volans, L F Prescott, A Proudfoot
Journal: BMJ (1998)

the Robin Hood index, a well validated measure of income differentials.Income differentials vary over time and from place to place, 7 suggesting that they are not just a fact of life.It could be argued that wide income differentials are an economic manifestation of people taking advantage of each other, and that it is the latter that causes premature mortality-through the emotional distress it generates.Solutions to apparently intractable public health problems like inequalities in health and unhealthy lifestyles may therefore lie in research into emotional wellbeing.A broad range of studies is needed to test the hypothesis that emotional distress creates susceptibility to physical illness and a further range is to research interventions which can prevent emotional distress and promote mental and social health.Two of the most promising approaches depend on a further body of research which shows that unresolved emotional distress in childhood is an important cause of emotional distress in adulthood. 13 14These approaches are parenting programmes and mental health promotion programmes in schools.The evidence showing that parenting programmes can both reverse emotional and behavioural problems 15 and prevent their emergence 16 is robust.Several school mental health promotion programmes have been subject to controlled trials which show a positive impact on emotional wellbeing. 17Through developing empathy and respect, both types of programmes improve self esteem in children and parents and increase their ability to give and receive social and emotional support.Long term follow up studies are needed to test the hypothesis that these programmes affect adult physical and mental health, but the epidemiological evidence suggesting that they could is strong.Successful implementation of the agenda defined in Our Healthier Nation will depend on research and development of such programmes.For this to happen doctors, and others who determine the allocation of NHS funds, will need to believe that emotional and social wellbeing are at least as important for health as physical wellbeing and invest both development and research funds accordingly.
Abstract 17935: Serum Parathyroid Hormone is Associated with Valvular Calcification but not with Aortic Root or Coronary Artery Calcification in Aortic Valve Stenosis
Authors: Lionel L Tastet, Romain Capoulade, Eric Larose, Mylène Shen, Marie-Annick Clavel, Abdellaziz Dahou, Marie Arsenault, Elisabeth Bédard, Jean G Dumesnil, Patrick Mathieu, Philippe Pibarot
Journal: Circulation (2014)

Introduction:  Several studies have suggested that key regulators of bone metabolism could be involved in pathophysiological pathways of aortic valve stenosis (AS). A recent study reported an association between increased parathyroid hormone (PTH) serum level and faster hemodynamic progression of AS.   Hypothesis:  The objective of this study was to assess the association between serum PTH levels and: aortic valve calcification (AVC), aorta root calcification (ARC), and coronary artery calcification (CAC) in patients with AS.   Methods:  Serum PTH levels were drawn in 144 patients with AS, prospectively recruited in the PROGRESSA study. Patients underwent a comprehensive Doppler echocardiography and a multidetector computed tomography (MDCT) within one month. AVC, ARC, and CAC were measured by MDCT.   Results:  The mean age was 67±12 years (75% male). Median serum PTH was 40.7 ng/L (IQR: 30.4 - 52.5 ng/L). Average peak aortic jet velocity (Vpeak) was 2.9±0.5 m/s and median AVC was 803 AU [IQR: 414 - 1377 AU]. There was a significant correlation between serum PTH levels and AVC (r = 0.18, p=0.03) but not with ARC (r = 0.05, p=0.48) or CAC (r = -0.13, p=0.10). After multivariate analysis adjusted for age, sex, Vpeak, hypertension and creatinine level, serum PTH levels remained independently associated with AVC (p=0.03).   Conclusions:  In patients with AS, increased serum levels of PTH are associated with higher AVC but not with ARC or CAC. These findings suggest that pathophysiological processes leading to ectopic calcification may be different in the aortic valve versus in the aorta or coronary arteries. Hyperparathyroidism may contribute to the mineralization of the aortic valve and could represent an interesting target of therapy in AS.
Computerized Physician Order Entry Systems and Medication Errors
Authors: Charles Safran, Don E Detmer
Journal: JAMA (2005)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Abstract 15835: Limiting Cardiac Ischemic Injury by Augmenting the MIF-AMPK Signaling Cascade with a Novel Class of MIF Receptor Agonists
Authors: Jingying Wang, Xiaoyan Yan, Eddie Yeung, Sunilkumar Gandavadi, Alissa A Hare, Xin Du, Lin Leng, William L Jorgensen, Ji Li, Richard Bucala
Journal: Circulation (2010)

Background: Macrophage migration inhibitory factor (MIF) is released by ischemic cardiomyocytes and exerts a protective effect by activating AMP-activated protein kinase (AMPK). While developing sm...
Correlations between epidermal growth factor receptor, her-2-neu and estrogen receptor in carcinoma breast-A study from cancer centre in India
Authors: R. Bhamrah, P. K. Julka, O. Nair, R. Parshad, S. Dattagupta, D. S. Bhamrah, R. Ralhan, S. Diwedi, G. K. Rath, G. Kumar
Journal: Journal of Clinical Oncology (2008)

22173 Background: The over expression of two members of the erbB oncogene family-the epidermal growth factor receptor protein (EGFR) and the Her-2 neu protein and estrogen receptor in breast cancer has been investigated by numerous authors. This study was performed on Indian patients to Correlate EGFR, Her-2-neu and ER in Breast Cancer. Methods: The expression of EGFR, Her-2-neu and ER in 210 specimens of breast cancer was detected by immunohistochemistry and EGFR expression was also clinico-pathologically corelated. Results: EGFR expression was positive in 41.4% of breast cancer. The expression of EGFR was positively correlated to pathological tumor size (p=0.001), Her-2 neu (p=0.000), Visceral metastasis (p=0.000) and Disease Free Survival (p=0.002) but inversely correlated to ER (p=0.000), and Overall survival (p=0.001). There was no correlation between EGFR and age, menopausal status, histology or lymph node status. Estrogen receptor was found to be positive in 66.2% and 28.6% were Her-2 neu positive. EGFR had positive correlation with Her-2 neu, p-value being highly significant (0.000). It had a negative correlation with ER, p-value 0.001.ER had a negative correlation with EGFR & Her-2 neu, p-value being 0.001 and 0.000 respectively. Her-2 neu had a positive correlation with EGFR, p-value being 0.000. It had a negative correlation with ER, p-value being 0.000. Her-2 neu receptor has a positive correlation with systemic recurrence (p value=0.001). Her-2 neu receptor has an inverse correlation with survival (p value=0.000). Estrogen receptor has an inverse correlation with systemic recurrence (p value=0.042). Estrogen receptor has a positive correlation with disease free survival (p value=0.033) Conclusions: The expression of EGFR and Her-2-neu in Breast Cancer is a bad prognostic marker and related to poor outcome. Future trials should aim at incorporating EGFR targeted therapies in order to improve the disease outcome, Her-2-neu targeted therapies are already in vogue. No significant financial relationships to disclose.
The Master of Destiny: A Biography of the Brain.
Authors: Frederick Tilney, Austen Fox Riggs
Journal: JAMA (1931)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
A novel intra-operative genetic predictive diagnosis for peritoneal recurrence in colorectal cancer patients
Authors: Hisae Iinuma, Toshiaki Watanabe, Keiji Matsuda, Toshiki Mimura, Keijirou Nozawa, Junko Tamura, Satoru Ohnaka, Toshinori Hayashi, Kota Okinaga, Tadahiro Takada
Journal: Clinical Cancer Research (2006)

A48   Background. Peritoneal recurrence after surgery is a serious concern in the prognosis of colorectal cancer patients. It is known that the conventional cytology of peritoneal washes lacks sensitivity and peritoneal recurrence can occur in cytology-negative patients. The aim of our study was to evaluate the usefulness of a novel rapid RNA amplification system with transcription-reverse transcription concerted reaction (TRC) to detect isolated tumor cells in peritoneal washes of colorectal cancer patients as an intra-operative genetic predictor of peritoneal recurrence. This study was a prospective cohort study and we compared the results of TRC with those of one-step real-time reverse transcription-polymerase chain reaction (RT-PCR) to clarify the characteristic qualities of TRC.Methods. A total of 161 cytology-negative colorectal cancer patients between 2001 and 2005 were included in this study. This study was approved by the institutional review board of our hospital and all patients provided written informed consent. At the beginning of the operation, peritoneal washes of Douglas cavity were collected from patients. One-half of each wash was used for cytopathology and the other half was used for molecular diagnosis. Total RNA was extracted from cells which were separated from washes, and TRC and one-step real-time RT-PCR of multiple marker genes (CEA, CK20, PBGD and GAPDH mRNA) were performed using a TRCRapid-160 and LightCycler, respectively. The clinical significance of the TRC was assessed by the peritoneal recurrence rate and overall survival.Results. The sensitivity and reproducibility of the TRC were equal to those of real-time RT-PCR. The rapidity and simplicity of the TRC were superior to those of one-step real-time RT-PCR. The detection time of marker gene by TRC was only 20 minutes compared with 70 minutes of real-time RT-PCR. Molecular detection of CEA and/or CK20 transcripts of the peritoneal washes by TRC showed a significant correlation to the depth of invasion, venous invasion, lymph node invasion, lymph node metastasis and stage. The peritoneal recurrence-free and overall survival rates of CEA and/or CK20 transcript-positive patients were significantly shorter than those of marker gene-negative patients. CEA and/or CK20 transcripts in peritoneal washes were independent prognostic factors of peritoneal recurrence-free survival and overall survival.Conclusion. For the intra-operative genetic predictive diagnosis of peritoneal recurrence, TRC may be more useful than real-time RT-PCR due to its rapidity and simplicity.
Statistically based splicing detection reveals neural enrichment and tissue-specific induction of circular RNA during human fetal development
Authors: Linda Szabo, Robert Morey, Nathan J. Palpant, Peter L. Wang, Nastaran Afari, Chuan Jiang, Mana M. Parast, Charles E. Murry, Louise C. Laurent, Julia Salzman
Journal: Genome biology (2015)

The pervasive expression of circular RNA is a recently discovered feature of gene expression in highly diverged eukaryotes, but the functions of most circular RNAs are still unknown. Computational methods to discover and quantify circular RNA are essential. Moreover, discovering biological contexts where circular RNAs are regulated will shed light on potential functional roles they may play.We present a new algorithm that increases the sensitivity and specificity of circular RNA detection by discovering and quantifying circular and linear RNA splicing events at both annotated and un-annotated exon boundaries, including intergenic regions of the genome, with high statistical confidence. Unlike approaches that rely on read count and exon homology to determine confidence in prediction of circular RNA expression, our algorithm uses a statistical approach. Using our algorithm, we unveiled striking induction of general and tissue-specific circular RNAs, including in the heart and lung, during human fetal development. We discover regions of the human fetal brain, such as the frontal cortex, with marked enrichment for genes where circular RNA isoforms are dominant.The vast majority of circular RNA production occurs at major spliceosome splice sites; however, we find the first examples of developmentally induced circular RNAs processed by the minor spliceosome, and an enriched propensity of minor spliceosome donors to splice into circular RNA at un-annotated, rather than annotated, exons. Together, these results suggest a potentially significant role for circular RNA in human development.
Abstract 20957: Paracrine and Functional Superiority of Human Cardiosphere-Derived Cells as Compared to Mesenchymal Stem Cells, Adipose-Derived Stem Cells or Bone Marrow Mononuclear Cells
Authors: Ke Cheng, Tao-Sheng Li, Konstantinos Malliaras, Baiming Sun, Noriko Matsushita, Linda Marban, Rachel Smith, Agnieszka Blusztajn, John Terrovitis, Eduardo Marban
Journal: Circulation (2010)