tbuckley/cabot-search huggingface dataset:
Behaviour therapy in dermatological practice
Authors: LOUIS H. J. BAR, BEN R. M. KUYPERS
Journal: British Journal of Dermatology (1973)

Behaviour therapy provides important psychotherapeutic possibilities for the treatment of dermatological disorders. Compulsive scratching and trichotillomania can be treated by aversive conditioning, or by the token economy technique. The treatment of blushing is described: assertive training is useful for patients with symptomatic erythema and erythrophobia. Hyperhidrosis can be treated by assertive training and systematic desensitization.
Proton Pump Inhibitor Therapy and Hip Fracture Risk
Authors: Jordan L. Geller, John S. Adams
Journal: JAMA (2007)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
COMPARISON OF VESSEL RESPONSE TO SIROLIMUS- VS. PACLITAXEL-ELUTING STENT TREATMENTS FOR BARE METAL IN-STENT RESTENOSIS: A VOLUMETRIC INTRAVASCULAR ULTRASOUND ANALYSIS
Authors: Kenji Sakamoto, Katsuhisa Waseda, Teruyoshi Kume, Kenji Sakata, Osami Kawarada, Joo-Yong Hahn, Paul G. Yock, Peter J. Fitzgerald, Yasuhiro Honda
Journal: Journal of the American College of Cardiology (2011)
Electrocardiographic changes after streptokinase-induced recanalization in patients with acute left anterior descending artery obstruction.
Authors: H Blanke, F Scherff, K R Karsch, R A Levine, H Smith, P Rentrop
Journal: Circulation (1983)

ECG changes were assessed in 15 patients in whom intracoronary streptokinase recanalized a totally occluded left anterior descending artery during acute myocardial infarction. These results were compared retrospectively with those in 22 comparable conventionally treated patients who underwent catheterization during the acute stage of infarction. Before angiography no significant differences were found in the sum of ST elevation (sigma ST increase V1-V6), the sum of R waves (sigma RV1-V6), or the number of Q waves (nQV1-V6) in leads V1 through V6. sigma ST increase V1-V6 was significantly lower in the streptokinase group than in control patients at all times after angiography. sigma RV1-V6 declined and nQV1-V6 increased in both groups during the first 12 hr, but there was no further change in the control group, whereas in the streptokinase group a significant increase in sigma RV1-V6 and decrease in nQV1-V6 followed. There was a significant correlation between long-term electrocardiographic (sigma RV1-V6; nQV1-V6) and angiographic findings (ejection fraction, akinetic segment length). Thus, the Q wave regression and increase in sigma RV1-V6 after streptokinase suggest, in accordance with angiographic findings, that jeopardized myocardium was salvaged by reperfusion.
EXPERIMENTAL STUDIES ON THE ETIOLOGY OF TYPHUS FEVER
Authors: Peter K. Olitsky
Journal: The Journal of Experimental Medicine (1921)

The work reported in this paper relates to the bacteria which can be cultivated from the blood and spleen of guinea pigs at different stages of infection with the virus of typhus fever. The studies show that during the period of incubation and before the onset of fever no ordinary bacteria appear in the cultures, while on the 1st day of the febrile reaction different bacteria were found in 6 of 26 guinea pigs cultured; on the 2nd day, in 10 of 16; on the 3rd day, in 3 of 4; and on the 4th day in cultures of all of the 4 guinea pigs observed. The findings indicate that the virus of typhus fever is distinct from ordinary cultivable bacteria, and, as the disease set up by the virus progresses, the infected guinea pigs become subject to invasion by secondary or concurrent bacteria which thus induce a mixed infection. The bacteria which under the influence of the virus of typhus fever thus invade the body of the guinea pig are of several kinds, and vary not only among themselves, but also with the day of the fever on which the examination is made. Thus, on the 1st day of the fever Plotz' bacilli were recovered twice and anaerobic streptococci, proteus bacilli, aerobic diphtheroids, Gärtner type bacilli, and Staphylococcus aureus each once. On the 2nd day Plotz' bacilli were found four times, anaerobic streptococci three times, Gärtner type bacilli, aerobic diphtheroids, Bacillus welchii, aerobic Gram-positive diplobacilli, and Staphylococcus aureus each once. On the 3rd day Plotz' bacilli were recovered once, as were anaerobic streptococci and Grtner type bacilli. On the 4th day Staphylococcus aureus was found twice and Plotz' bacilli and Bacillus proteus each once. This variation in the kind of bacteria as well as the lack of predominance of one kind over another during the different stages of the febrile reaction in guinea pigs leads us to infer that they occur concurrently with the typhus virus. And since the more unusual of these organisms, the Plotz bacillus, the anaerobic streptococcus, the aerobic diphtheroid, and the diplobacillus are non-pathogenic for guinea pigs, while the more common bacteria such as the Gärtner type bacillus, Welch's bacillus, the proteus bacillus, and the staphylococci induce distinctive effects, and since all the bacteria could be suppressed without their reappearance in guinea pig passages of the virus containing them, we believe that they are independent and unrelated to the true virus of typhus fever.
Death and Epistaxes
Authors: John T. Flynn
Journal: JAMA (1969)

<h3>To the Editor:—</h3> Physicians think of clotted blood as a hazard largely in intravascular areas; they welcome clot formation when faced with internal or surface bleeding. The lowly epistaxis is passed over hurriedly but it can, unnoticed, quietly suffocate the patient. <h3>Report of Cases:—</h3> Emergency resuscitation after trauma to the head led to the discovery of a large blood clot overlying the larynx, with recovery of respiratory function following removal. Marked narrowing of tracheal and bronchial airways by a thick layer of clotted fibrin and blood was found at autopsy in a man who died in uremic coma. A similar massive clot was found in the posterior portion of the pharynx of a man who died in hepatic coma. Nasal packing for epistaxis resulted in the accumulation of a mass of clotted blood in the trachea and larynx with increasing respiratory distress. A large mass of
Warning Against Fraudulent Insurance Agent.
Authors: P. H. Burton
Journal: JAMA (1906)

Fargo, N. D., Oct. 6, 1906. <h3>To the Editor:</h3> —There is a man traveling about the country representing himself as an agent of the Columbian Life Insurance Company of Boston. He goes by the name of Bailey and other aliases; he sells stock and appoints agents. The officials of the company inform me that he has swindled a great many doctors and that they have had detectives on his trail, but have not been able to get him. He is a large man, weight 240 pounds, about 5 feet 11 inches tall, dimple in chin, gray or blue eyes, poses as a Mason and an Elk. I believe publicity inThe Journaland request for other journals to copy might save a good many doctors money and might be means of apprehending this criminal. [This case was the subject of a warning inThe Journal, May 12, 1906, page 1463.]
Reviews and Notes: Care for Frail Elders: Developing Community Solutions
Authors: Van J. Stitt
Journal: Annals of Internal Medicine (1993)

Literature of Medicine1 December 1993Reviews and Notes: Care for Frail Elders: Developing Community SolutionsVan J. Stitt, MDVan J. Stitt, MDDurham Regional Hospital, Durham, NC 27704.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-119-11-199312010-00028 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail Care for Frail Elders: Developing Community SolutionsWalter N. Leutz, John A. Capitman, Margaret MacAdam, and Ruby Abrahams. 300 pages. Westport, Connecticut: Auburn House; 1992. $45.00.Walter N. Leutz and colleagues have written an easy-to-read, timely book on a topic that has long deserved attention. The authors take a highly complex area and, like a master architect, lay a firm foundation and build, in a concise and comprehensible manner, a structure that a community can use to improve its care for the frail elderly. The book is written by human service providers for human service providers and managers who care for the ... Author, Article, and Disclosure InformationAffiliations: Durham Regional Hospital, Durham, NC 27704. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 December 1993Volume 119, Issue 11Page: 1153KeywordsElderly ePublished: 15 August 2000 Issue Published: 1 December 1993 Copyright & PermissionsCopyright © 1993 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
The Potter Electroturbinometer
Authors: STANLEY J. SARNOFF, ERIK BERGLUND
Journal: Circulation Research (1953)

The flowmeter described is a turbine which can be driven by the bloodstream. In the turbine is a magnet which induces a recordable signal in an adjacent coil. The flowmeter records pulsating flow as well as steady flow; it is insensitive to temperature and wide variations of blood viscosity. The pressure drop is rather high. The baseline and calibration are steady over long periods of time. The flowmeter has been successfully used for continuously recording the systemic output in the dog.
Biliary physiology and disease: Reflections of a physician-scientist
Authors: Gustav Paumgartner
Journal: Hepatology (2009)

A review is presented of Gustav Paumgartner's five decades of research and practice in hepatology focusing on biliary physiology and disease. It begins with studies of the excretory function of the liver including hepatic uptake of indocyanine green, bilirubin, and bile acids. The implications of these studies for diagnosis and understanding of liver diseases are pointed out. From there, the path of scientific research leads to investigations of hepatobiliary bile acid transport and the major mechanisms of bile formation. The therapeutic effects of the hydrophilic bile acid, ursodeoxycholic acid, have greatly stimulated these studies. Although ursodeoxycholic acid therapy for dissolution of cholesterol gallstones and some other nonsurgical treatments of gallstones were largely superseded by surgical techniques, ursodeoxycholic acid is currently considered the mainstay of therapy of some chronic cholestatic liver diseases, such as primary biliary cirrhosis. The major mechanisms of action of ursodeoxycholic acid therapy in cholestatic liver diseases are discussed. An attempt is made to illustrate how scientific research can lead to advances in medical practice that help patients. (HEPATOLOGY 2010:51:1095–1106.)
Insulinotropic action of secretin
Authors: R. J. Mahler, H. Weisberg
Journal: BMJ (1967)

Pyloric Stenosis in Turner's Syndrome SIR,-The prevalence of congenital hyper- trophic stenosis in the general population is estimated to be about 2 to 5 per 1,000 live births,'`and Carter was able to demonstrate that the sex ratio for this malformation amounted to 5:1, boys being more affected than girls.'Benson and King have drawn attention to a possibly high prevalence of this condition in patients with Turner's syn- drome.'We have investigated a series of 43 patients with Turner's syndrome and found two patients with congenital pyloric stenosis.'The diagnosis of Turner's syndrome in Case 1 was established at the age of 19 years on the following criteria:(1) Sexual infantilism with primary amenor- rhoea, infantile external and internal genitalia, and absence of breast development.
Abstract 1186: Identification of p53 regulatory microRNAs
Authors: Xin Zhang, Matthias Dobbelstein
Journal: Cancer Research (2011)

Abstract Purpose: microRNAs (miRNAs) play very important roles in gene regulation, by interfering with target mRNA stability and/or translation. A number of specific miRNAs have been identified to function as oncogenes or tumor suppressors. We originally found that miR-192/-215 constitute part of the p53 tumor suppressor network and can act as effectors and regulators of p53. In this project, we aim to identify more p53-regulatory miRNAs to gain deeper insight into p53 regulation. Experiments: We developed an immunofluorescence-based screen to identify p53-regulatory miRNAs. Briefly, U2OS cells, an osteosarcoma cell line with wild type p53, were transfected with a collection of miRNA expression plasmids. The cellular levels of p53 were then evaluated by subsequent immunofluorescence analysis via high content BD pathway. Results: From our screen, we identified the known p53-regulatory miRNA miR-125b (Le et al., 2009), that can reduce the levels of p53, which in turn validated our screen method. Several other candidates identified from this screen are undergoing study in the context of the p53 tumor suppressor pathway. These miRNAs might be novel therapeutic targets for diagnosis and treatment of human cancers. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 102nd Annual Meeting of the American Association for Cancer Research; 2011 Apr 2-6; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2011;71(8 Suppl):Abstract nr 1186. doi:10.1158/1538-7445.AM2011-1186
Physician Medical Identity Theft
Authors: Shantanu Agrawal, Peter Budetti
Journal: JAMA (2012)

IT TOOK SEVERAL MONTHS FOR ONE PHYSICIAN TO LEARN THAT she was a victim of medical identity theft. This realization occurred after patients reported that her name was on their Medicare Summary Notices although they had never seen her. A fraudulent clinical practice had enrolled in Medicareusinghernamewithoutherknowledge.Anotherphysician had retired from clinical practice but decided to work part-time. Nearly 2 years after sending out job applications, he was asked by Medicare to return more than $350 000 in overpayments made to a practice he had interviewed with but never joined. The Department of Treasury began to garnish his Social Security payments for unpaid debts. Investigation revealed that both stolen identities were part of a complex Medicare fraud scheme that victimized numerous physicians and resulted in the criminal conviction of 6 perpetrators. The physicians’ identities have been restored and their financial liabilities and enrollment records have been cleared, but this situation highlights the importance of understanding and preventing physician medical identity theft. Scope of the Issue Medical identity theft is the appropriation or misuse of a patient’s or physician’s unique medical identifying information to obtain or bill public or private payers for fraudulent medicalgoodsorservices.Forphysicians, this information includes theNationalProviderIdentifier(NPI),TaxIdentificationNumber (TIN), and medical licensure information. Recent data revealthatmorethan3600casesof(physicianandpatient)medical identity theft were reported to the Federal Trade Commission (FTC) in 2009, with more than 12 000 cases reported between 2007-2009. It is likely that substantial medical identity theft is unreported. FTC data also show that 32% of thefts are discovered more than 1 year after they occur. The Center for Program Integrity (CPI) at the Centers for MedicareM medical job
A spectrum of biophysical interaction modes between T cells and different antigen-presenting cells during priming in 3-D collagen and in vivo
Authors: Matthias Gunzer, Carsten Weishaupt, Anja Hillmer, Yasmin Basoglu, Peter Friedl, Kurt E. Dittmar, Waldemar Kolanus, Georg Varga, Stephan Grabbe
Journal: Blood (2004)
Solitary Cerebral Metastasis From Pulmonary Cancer Prolonged Survival After Surgery
Authors: Luciano M. Modesti
Journal: JAMA (1975)

THE OUTLOOK for patients with cerebral metastasis of bronchogenic carcinoma is highly unfavorable.<sup>1-2</sup>Patients who have not been operated on have an average life expectancy of three months after the onset of the cerebral symptoms,<sup>1</sup>and the operative mortality of cerebral metastases is as high as 38%.<sup>3</sup>In cases where surgery is apparently instrumental in prolonging life, the quality of survival may be poor.<sup>1</sup>These findings, coupled with the knowledge that cerebral metastases are often multiple,<sup>3-4</sup>have led some authors to conclude that surgery should not be considered the treatment of choice for cerebral metastasis of lung carcinoma.<sup>4</sup> On the other hand, innumerable cases of prolonged, good quality survival following surgery can be found in the literature.<sup>1-3,5</sup>Rarely, there are reports of apparent cures in which patients have lived five years or more beyond craniotomy. This communication reports just such a case. <h3>Report</h3>
Reflux Disease and Barrett's Esophagus
Authors: G. W. Falk, J. E. Richter
Journal: Endoscopy (1998)

Gastroesophageal reflux disease (GERD) is a common clinical problem. New information suggests that infection with Helicobacter pylori may protect patients from developing GERD and its complications. Endoscopy may be used by clinicians to tailor GERD therapy, but an empirical trial of a proton-pump inhibitor may be an alternative diagnostic approach. Studies continue to show that laparoscopic antireflux surgery is a cost-effective treatment option for patients requiring maintenance therapy with proton-pump inhibitors. However, the minimally invasive nature of the operation should not alter the indications for antireflux surgery, especially for patients with atypical symptoms. It remains unclear why some patients with GERD develop Barrett's esophagus, whereas others do not. Recent guidelines suggest that patients with long-standing GERD symptoms, especially white men over 50 years of age, should undergo endoscopy at least once to screen for Barrett's esophagus. Debate concerning short-segment Barrett's esophagus continues. Intestinal metaplasia at a normal-appearing gastroesophageal junction may be associated with intestinal metaplasia of the stomach and infection with H. pylori, whereas short tongues of intestinal metaplasia in the esophagus are associated with GERD. Cancer surveillance is indicated in short-segment Barrett's esophagus, as dysplasia may develop in these patients. Barrett's esophagus is the only known risk factor for the development of esophageal adenocarcinoma, but the incidence of adenocarcinoma may be lower than previously reported. New clinical guidelines for endoscopic surveillance suggest that the surveillance interval should be lengthened to every two years in patients without dysplasia. Newer treatment options, such as thermal ablation and photodynamic therapy, continue to show promise, but are not yet ready for routine clinical use.
Abstract P3-14-03: Pathological complete response after primary chemotherapy as a surrogate end point of treatment efficacy in breast cancer patients: A trial-based meta-analysis
Authors: V Amoroso, A Berruti, F Gallo, V Bertaglia, E Paloja, EL Simoncini, D Generali, A Bottini, P Bruzzi, MP Sormani
Journal: Cancer Research (2013)

Abstract Background: The relationship between pathological complete response (pCR) and improved long-term prognosis was first reported in the landmark NSABP B-18 and B-27 trials and then validated in large cohort studies and in meta-analyses. Whether pCR, as surrogate end point, should capture the full effect of neoadjuvant chemotherapy on survival is still unproven. To assess the role of pCR as surrogate of disease-free survival (DFS) and overall survival (OS) at a trial level, we performed a trial-based meta-regression of randomized studies comparing different neoadjuvant therapies with data on both pCR rates and outcome end points. Methods: The systematic search included electronic databases and proceeding of international meetings. No restriction regarding treatment types was set up except for endocrine therapy trials that were excluded. We did not include studies comparing neoadjuvant versus adjuvant chemotherapy. Relevant data were extracted from each selected trial: patients randomly assigned to treatment and analyzed per arm, tumor stage, type of chemotherapy and targeted therapy, cycles number, additional post-surgical treatments, number of patients achieving pCR and number of outcome events per arm. For each trial, the experimental and the control arm were defined. Treatment effects on DFS and OS were expressed as hazard ratios (HRs) and on pCR as odd ratios (ORs). A weighted regression analysis was performed on log-transformed treatment effect estimates to test the association between the treatment effects on the surrogate outcome and the treatment effects on the clinical outcome. Results: A final set of 28 trials, 57 arms and 29 contrasts for a total of 13,738 patients was included in the analysis. As one trial had 3 arms, it contributed two contrasts to the analysis. The regression of the logHR for DFS on the logOR for pCR, using the complete set of data, demonstrated a weak but significant association between the two effects (R2 = 0.16, p-value = 0.03). Sixteen% of the variability among the effects on DFS can be explained by the observed effects on pCR. The regression of the logHR for OS on the logOR for pCR demonstrated a weak association between the two effects (R2 = 0.15, p-value = 0.04). Conclusions: This trial-based meta-regression showed a possible role of pCR as surrogate end point for DFS and OS in breast cancer patients treated with neoadjuvant chemotherapy. The surrogacy of pCR warrants to be further evaluated in more homogeneous subsets of clinical trials in the neoadjuvant chemotherapy-based setting. Citation Information: Cancer Res 2013;73(24 Suppl): Abstract nr P3-14-03.
Adenovirus infections following allogeneic stem cell transplantation: incidence and outcome in relation to graft manipulation, immunosuppression, and immune recovery
Authors: Suparno Chakrabarti, Vivien Mautner, Husam Osman, Kathryn E. Collingham, Chris D. Fegan, Paul E. Klapper, Paul A. H. Moss, Donald W. Milligan
Journal: Blood (2002)