PRESSOR ACTIVITY OF DESOXYCORTICOSTERONE ACETATE IN NORMOTENSIVE AND HYPERTENSIVE SUBJECTS
Authors: G A PERERA, D W BLOOD
Journal: Annals of Internal Medicine (1947)

Article1 September 1947PRESSOR ACTIVITY OF DESOXYCORTICOSTERONE ACETATE IN NORMOTENSIVE AND HYPERTENSIVE SUBJECTSGEORGE A. PERERA, M.D., DAVID W. BLOOD, M.D.GEORGE A. PERERA, M.D., DAVID W. BLOOD, M.D.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-27-3-401 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptPrevious studies1 have demonstrated that the administration of desoxycorticosterone acetate (DCA) and sodium chloride to patients without hypertension or adrenal disease may be associated with an increase in blood pressure. Significant changes were not apparent until the second or third week of drug injection. Because of the possibility that the adrenal cortex might be concerned in the development or maintenance of hypertensive vascular disease in man,2, 3 the blood pressure response of hypertensive individuals to DCA was compared to that observed in subjects without hypertension.METHODSObservations were made on 10 normotensive subjects and 14 patients with uncomplicated hypertensive vascular...Bibliography1. PERERAKNOWLTONLOWELLLOEB GAAIARF: Effect of desoxycorticosterone acetate on the blood pressure of man, Jr. Am. Med. Assoc., 1944, cxxv, 1030-1035. CrossrefGoogle Scholar2. PERERA GA: The relationship of the adrenal cortex to hypertension: observations on the effect of hypoadrenalism on a patient with hypertensive vascular disease, Jr. Am. Med. Assoc., 1945, cxxix, 537-538. CrossrefGoogle Scholar3. PERERABLOOD GADW: Disturbance in salt and water metabolism in hypertension, Am. Jr. Med., 1946, i, 602-606. CrossrefGoogle Scholar4. CLINTONTHORN MGW: Effect of desoxycorticosterone acetate administration on plasma volume and electrolyte balance of normal human subjects, Bull. Johns Hopkins Hosp., 1943, lxxii, 255-264. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: New York, N. Y.*Received for publication March 18, 1947.From the Department of Medicine, Columbia University College of Physicians and Surgeons, and the Presbyterian Hospital and the Research Service, First (Columbia) Division, Goldwater Memorial Hospital.This study was made possible through the generosity of the Albert and Mary Lasker Foundation.†Desoxycorticosterone acetate (Doca) was supplied through the courtesy of Dr. L. A. Pirk of Roche-Organon, Inc., Nutley, New Jersey. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byHypertensive Disease Without HypertensionInterrelationships of Oral Contraceptives and HypertensionPhysiologie und Pathologie des Renin/Angiotensin-SystemsHypertonieHypertonieThe pathogenesis of essential hypertensionLebensaussichten von essentiellen Hypertonikern bei jahrelang eingehaltener salzfreier Di�tDie NebenniereDie koordinierte Rolle von Nerven, Hormonen und Elektrolyten in der Pathophysiologie des BlutdruckesPharmacologic Aspects of Adrenocortical Steroids and ACTH in ManORTHOSTATIC HYPOTENSION: REPORT OF A CASE REFRACTORY TO VASOCONSTRICTOR DRUGS; WITH OBSERVATIONS ON USE OF DESOXYCORTICOSTERONE, LNOREPINEPHRINE, ACTH AND VASOPRESSOR POTENTIATING SUBSTANCES*EDWIN A. CROST, M.D., HERZL FRIEDLANDER, M.D.Altered metabolic response prior to the development of hypertensive vascular diseaseDietotherapy in hypertensive diseaseNewer concepts of the role of sodium in diseasePathogenesis of hypertensionA Hypertensive Syndrome with Relative Adrenal Cortical OveractivityHypertensionThe Significance of Endocrine Factors on Renal Function and Blood Pressure as Revealed by a Case of Chromophobe Adenoma of the Pituitary1Physiology of the Adrenal CortexClinical and metabolic study of 11-dehydro-17-hydroxy-corticosterone acetate (Kendall Compound E) in hypertension, Addison's disease and diabetes mellitusRole of the neurohypophysis in the pathogenesis of hypertension and some allied disorders associated with agingMetabolic Changes in Man Following Adrenal and Pituitary Hormone AdministrationImmediate pressor effect of desoxycorticosterone acetate in arterial hypertensionPhysiology of essential hypertensionMechanisms of human hypertension 1 September 1947Volume 27, Issue 3Page: 401-404KeywordsAdrenal cortexBlood pressureDrugsHospital medicineHypertensionSodium chlorideSurgeonsVascular diseases ePublished: 1 December 2008 Issue Published: 1 September 1947 PDF downloadLoading ...