Urinary Solute Excretion as an Index of Renal Homograft Rejection
Authors: DAVID A. OGDEN
Journal: Annals of Internal Medicine (1966)

Article1 April 1966Urinary Solute Excretion as an Index of Renal Homograft RejectionDAVID A. OGDEN, M.D., JOSEPH H. HOLMES, M.D., F.A.C.P.DAVID A. OGDEN, M.D.Search for more papers by this author, JOSEPH H. HOLMES, M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-64-4-806 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptInitial technical success is usually achieved in human renal transplantation. Subsequent survival of the homograft and of the patient requires successful control of graft rejection. Early recognition of transplant rejection is requisite to successful reversal of rejection.Renal homograft rejection may be clinically manifest by fever, exacerbation of hypertension, tenderness at the transplant site, weight gain, edema, malaise, mental depression, anorexia, and arthralgia (1-4). Oliguria accompanied by proteinuria (2), lymphocytes in the urine sediment (3), and urinary enzyme alterations (5) may occur. A secondary increase in blood urea nitrogen (BUN) and serum creatinine associated with a decrease in creatinine clearance...References1. MURRAYMERRILLHARRISONWILSONDAMMIN JEJPJHREGJ: Prolonged survival of human-kidney homografts by immunosuppressive drug therapy. New Eng. J. Med. 268: 1315, 1963. CrossrefMedlineGoogle Scholar2. STARZLMARCHIOROWADDELL TETLWR: The reversal of rejection in human renal homografts with subsequent development of homograft tolerance. Surg. Gynec. Obstet. 117: 385, 1963. MedlineGoogle Scholar3. HUMEMAGEEKAUFFMANRITTENBURYPROUT DMJHHMMSGR: Renal homotransplantation in man in modified recipients. Ann. Surg. 158: 608, 1963. CrossrefMedlineGoogle Scholar4. STARZLMARCHIOROPORTERMOORERIFKINDWADDELL TETLKACADWR: Renal homotransplantation: late function and complications. Ann. Intern. Med. 61: 470, 1964. LinkGoogle Scholar5. 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Medicine (Balt.) 40: 347, 1961. CrossrefMedlineGoogle Scholar23. DAVIDSONLEVINSKYBERLINER DCNGRW: Maintenance of potassium excretion despite reduction of glomerular filtration during sodium diuresis. J. Clin. Invest. 37: 548, 1958. CrossrefMedlineGoogle Scholar24. WESSON LG: Glomerular and tubular factors in the renal excretion of sodium chloride. Medicine (Balt.) 36: 281, 1957. CrossrefMedlineGoogle Scholar26. STARZLMARCHIOROHOLMESWADDELL TETLJHWR: The incidence, cause, and significance of immediate and delayed oliguria or anuria after human renal transplantation. Surg. Gynec. Obstet. 118: 819, 1964. MedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: DAVID A. OGDEN, M.D.; JOSEPH H. HOLMES, M.D., F.A.C.P.Affiliations: Denver, ColoradoFrom the Department of Medicine, Denver Veterans Administration Hospital, and the University of Colorado Medical Center, Denver, Colo.Requests for reprints should be addressed to David A. Ogden, M.D., Chief, Renal Section, Veterans Administration Hospital, 1055 Clermont St., Denver, Colo. 80220. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byMechanism, Pathophysiology, Diagnosis, and Management of Renal Transplant RejectionRelative Density of Urine: Methods and Clinical SignificanceDiagnostic value of urinary N-acetyl-β-d-glucosaminidase, its isoenzymes and the fractional excretion of sodium following renal transplantationMeasurement of Urine Electrolytes: Clinical Significance and MethodsFractional excretion of sodium after renal transplantationEtiology and diagnosis of early post-transplantation oliguriaImmunologic Tests for RejectionDiagnosis of Allograft RejectionProteinuria After Human Renal Transplantation: II. A Functional Identification of Two Types of Rejection CrisisThe pathophysiology of renal allograft rejection: A collective reviewTransplantationPLASMA RENIN ACTIVITY AFTER ALLOGENIC KIDNEY TRANSPLANTATION IN MANRenal Transplantation108. Analyse verschiedener Untersuchungsmethoden auf ihre Brauchbarkeit zur Frühdiagnose akuter Abstoßungskrisen von LeichennierentransplantateTHE DIAGNOSIS OF REJECTION OF RENAL ALLOTRANSPLANTS IN MANAnalyse verschiedener Untersuchungsmethoden auf ihre Brauchbarkeit zur Frühdiagnose akuter Abstoßungskrisen von LeichennierentransplantatenChronic renal homograft functionDie renal-vasculäre HypertonieSerum Erythropoietin After Renal HomotransplantationPETER H. ABBRECHT, M.D., PH.D., JAMES A. GREENE JR., M.D. 1 April 1966Volume 64, Issue 4Page: 806-816KeywordsAttentionBlood urea nitrogenCreatinineExcretionHomograftsHospital medicineRenal transplantationTransplantationUrineWeight gain ePublished: 1 December 2008 Issue Published: 1 April 1966 PDF downloadLoading ...