PROGRESSIVE EXOPHTHALMOS DEVELOPING 12 YEARS AFTER THYROIDECTOMY FOR DIFFUSE TOXIC GOITER
Authors: J J McHUGH, R C MELLINGER
Journal: Annals of Internal Medicine (1958)

Case Reports1 October 1958PROGRESSIVE EXOPHTHALMOS DEVELOPING 12 YEARS AFTER THYROIDECTOMY FOR DIFFUSE TOXIC GOITERJOHN J. MCHUGH, M.D., RAYMOND C. MELLINGER, M.D.JOHN J. MCHUGH, M.D.Search for more papers by this author, RAYMOND C. MELLINGER, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-49-4-955 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptEndocrine exophthalmos can occur with or without evident hyperthyroidism, or may develop only after therapeutically induced remission of the thyrotoxicosis. The cause of the disorder has not been completely explained, but a pituitary factor, either thyrotropin or a physiologically related substance, is thought to be involved in its pathogenesis. The unusual history is presented of a patient who developed severe infiltrative ophthalmopathy 12 years after thyroidectomy. The normal pituitary-thyroid relationship associated with the exophthalmos is a significant feature of the case study.CASE REPORTA 62 year old housewife was first examined at the Henry Ford Hospital in January, 1957,...Bibliography1. WijnbladhMossbergLiungman HJHS: On exophthalmos and its treatment, Acta endocrinol. 17: 442, 1954. MedlineGoogle Scholar2. Sloan LW: Ocular manifestations; systemic correlations, in The thyroid, edited by Werner, S. C., 1955, P. B. Hoeber, Inc., New York, p. 475. Google Scholar3. Greer MA: The effect on endogenous thyroid activity of feeding desiccated thyroid to normal human subjects, New England J. Med. 244: 385, 1951. CrossrefMedlineGoogle Scholar4. WernerHamiltonNemeth SCHM: Graves' disease: hyperthyroidism or hyperpituitarism?, J. Clin. Endocrinol. and Metabolism 12: 1561, 1952. CrossrefGoogle Scholar5. PerlmutterSlater MS: Use of thyroid hormone to differentiate between hyperthyroidism and euthyroidism, J. A. M. A. 158: 718, 1955. CrossrefMedlineGoogle Scholar6. WernerSpoonerHamilton SCMH: Further evidence that hyperthyroidism (Graves' disease) is not hyperpituitarism: effects of triiodothyronine and sodium iodide, J. Clin. Endocrinol. and Metabolism 15: 715, 1955. CrossrefGoogle Scholar7. WernerSpooner SCM: A new and simple test for hyperthyroidism employing 1-triiodothyronine and the twenty-four hour I131 uptake method, Bull. New York Acad. Med. 31: 137, 1955. MedlineGoogle Scholar8. Werner SC: Euthyroid patients with early eye signs of Graves' disease. Their response to 1-triiodothyronine and thyrotropin, Am. J. Med. 18: 608, 1955. CrossrefMedlineGoogle Scholar9. Werner SC: Response to triiodothyronine as index of persistence of disease in the thyroid remnant of patients in remission from hyperthyroidism, J. Clin. Investigation 35: 57, 1956. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Detroit, Michigan*Received for publication June 11, 1957.From the Department of Medicine of the Henry Ford Hospital, Detroit, Michigan.Requests for reprints should be addressed to Raymond C. Mellinger, M.D., Henry Ford Hospital, Detroit 2, Michigan. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 October 1958Volume 49, Issue 4Page: 955-958KeywordsEndocrine therapyHospital medicineHyperthyroidismLaboratory testsPathogenesisThyroidThyroid-stimulating hormoneThyroidectomy ePublished: 1 December 2008 Issue Published: 1 October 1958 PDF downloadLoading ...