tbuckley/cabot-search huggingface dataset:
IgE antibodies in relation to prevalence and multimorbidity of eczema, asthma, and rhinitis from birth to adolescence
Authors: N. Ballardini, A. Bergström, C‐F. Wahlgren, M. van Hage, E. Hallner, I. Kull, E. Melén, J. M. Antó, J. Bousquet, M. Wickman
Journal: Allergy (2015)

Eczema, asthma, and rhinitis affect a large proportion of children, but their prevalence varies with age. IgE antibodies are also common in the pediatric population. However, the links between IgE, disease, and trajectories are unclear.To better understand the links between sensitization and disease, we studied IgE sensitization ever in relation to eczema, asthma, and rhinitis, in children followed up to 16 years of age.From the Swedish population-based birth cohort BAMSE, 2607 children were included. Parental reports from six time points between 1 and 16 years were used to identify children with eczema, asthma, and rhinitis. Blood was collected at 4, 8, and 16 years, and sensitization ever was defined as allergen-specific IgE ≥0.35 kUA /l to common food and/or inhalant allergens at any time point. Odds ratios for eczema, asthma, rhinitis, and multimorbidity in relation to sensitization ever were calculated using generalized estimating equations.Fifty-one percent were sensitized at least once up to 16 years. Almost a quarter of ever-sensitized children did not have any disease. After adjustment for potential confounders, sensitization ever was significantly associated with the following: (i) eczema throughout childhood, (ii) multimorbidity of eczema, asthma, and rhinitis from 1 to 16 years (OR for multimorbidity: 5.11, 95% CI: 3.99-6.55), (iii) asthma and rhinitis from 4 to 16 years of age.Specific IgE is strongly associated with eczema and allergic multimorbidity throughout childhood and with asthma and rhinitis from age 4 years. However, 23% of the children with IgE sensitization do not develop any disease in childhood.
Good Publication Practice for Communicating Company-Sponsored Medical Research: GPP3
Authors: Wendy P. Battisti, Elizabeth Wager, Lise Baltzer, Dan Bridges, Angela Cairns, Christopher I. Carswell, Leslie Citrome, James A. Gurr, LaVerne A. Mooney, B. Jane Moore, Teresa Peña, Carol H. Sanes-Miller, Keith Veitch, Karen L. Woolley, Yvonne E. Yarker
Journal: Annals of Internal Medicine (2015)

This updated Good Publication Practice (GPP) guideline, known as GPP3, builds on earlier versions and provides recommendations for individuals and organizations that contribute to the publication of research results sponsored or supported by pharmaceutical, medical device, diagnostics, and biotechnology companies. The recommendations are designed to help individuals and organizations maintain ethical and transparent publication practices and comply with legal and regulatory requirements. These recommendations cover publications in peer-reviewed journals and presentations (oral or poster) at scientific congresses. The International Society for Medical Publication Professionals invited more than 3000 professionals worldwide to apply for a position on the steering committee, or as a reviewer, for this guideline. The GPP2 authors reviewed all applications (n = 241) and assembled an 18-member steering committee that represented 7 countries and a diversity of publication professions and institutions. From the 174 selected reviewers, 94 sent comments on the second draft, which steering committee members incorporated after discussion and consensus. The resulting guideline includes new sections (Principles of Good Publication Practice for Company-Sponsored Medical Research, Data Sharing, Studies That Should Be Published, and Plagiarism), expands guidance on the International Committee of Medical Journal Editors' authorship criteria and common authorship issues, improves clarity on appropriate author payment and reimbursement, and expands information on the role of medical writers. By following good publication practices (including GPP3), individuals and organizations will show integrity; accountability; and responsibility for accurate, complete, and transparent reporting in their publications and presentations.
Differential Effects of Progenitor Cell Populations on Myocardial Neovascularization and Left Ventricular Remodeling after Myocardial Infarction
Authors: Christophe L Dubois, Xiashun Liu, Glenn Marsboom, Helene Depelteau, Peter Pokreisz, Witold Streb, Lertlak Chaothawee, Frederik Maes, Hilde Gillijns, Marijke Pellens, Desire Collen, Thierry VandenDriessche, Marinee Chua, Frans Van de Werf, Jan Bogaert, Stefan Janssens
Journal: Circulation (2008)

Background:  Cardiac progenitor cell transfer may improve myocardial repair after acute myocardial infarction (AMI), but responsible cell types and mechanisms remain uncertain.   Methods:  In a blinded, randomized, controlled study, we infused allogeneic porcine LentiGFP-infected mesenchymal stem cells (MSC, n=11, 10±2x10 6  CD29 – 44 –90 cells, capable of adipogenic and osteogenic differentiation), autologous late-outgrowth endothelial progenitor cells (EPC, n=10, 34±22x10 6  CD29 –31 cells, capable of tube formation) or vehicle (CON, n=10) in the CX artery 1 w after AMI induced by 90 min balloon occlusion. Hemodynamic and cine MRI measurements (dP/dt max/min  and ejection fraction, EF) were performed at 1w and 7w follow-up. We measured LV remodeling from end-diastolic and end-systolic volumes (EDV, ESV) and quantified infarct size and transmurality on late enhanced images. We evaluated the secretome of cultured EPC and MSC and compared changes in relative upslope (RU) of first-pass perfusion images and vascular density on postmortem sections from infarct core and border zones.   Results:  While systolic function (dP/dt max/min  and EF) at 7 w was similar between groups, LVEDV increased in MSC and CON pigs, but not in EPC pigs [+23.3 (25–75 th  percentile 1.7;27.9) and +26 ml/m 2  (17.9;31.9) vs +0.8 ml/m 2  (−10.1;18.8), resp,  P  2  (5.9;14.5) in MSC and CON, resp], vs −1.8 ml/m 2  (−13.5;0.7) in EPC ( P =0.06). After EPC transfer, infarct size decreased more in segments with >50% infarct transmurality ( P =0.01 vs MSC and CON). Myocardial perfusion increased more in EPC than in MSC and CON [RU +72% (−2;119) vs −2% (−28;84) and +25% (−33;236), resp], and was associated with greater vascular density in infarct border zones ( P =0.01) and with higher levels of pro-angiogenic growth factors, PLGF and FGF2 in EPC secretome (1730±1002 and 75±44 pg/10 6  cells resp vs 73±16 and 19±12 in MSC secretome,,n=5). No evidence of cell transdifferentiation was observed at 7w.   Conclusion:  Infusion of late-outgrowth EPCs after AMI limits negative LV remodeling but does not mediate cardiomyogenesis. EPC transfer may hold promise for heart failure prevention via paracrine matrix-modulating or pro-angiogenic effects.
Recommendations to Improve Cardiac Arrest Survival
Authors: Julie A. Jacob
Journal: JAMA (2015)

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Surveillance of susceptibility patterns among isolates from pulmonary intensive care units for four years in Turkey
Authors: Ibrahim Erayman, Mehmet Yavsan, Celalettin Korkmaz, Emine Karatas, Mustafa Tosun, Mustafa Göktepe, Kürsat Uzun
Journal: European Respiratory Journal (2014)

Hospital acquired infections were commonly caused by antimicrobial resistant pathogens, which can increase morbidity and mortality. In our study, we investigated the microbiological data of critically ill patients and surveillance of susceptibility patterns among isolates from pulmonary critical care units for four years to an appropriate choice of initial antibiotic treatment for hospital acquired infection in Turkey. In the ICU, endotracheal aspirates is collected twice per week as surveillance cultures. If fever is occured in critically ill patients, endotracheal aspirates, blood and urine collected for appropriate antibiotic therapy. Standard Centers for Diseases Control and Prevention (CDC)/National Nosocomial Infections Surveillance System definitions were used to identify nosocomial infections. Followed in the intensive care 57 of the 154 patients were women (37%) and 97 patients were men (63%). 221 pathogens were isolated from 298 BAL samples. 194 isolates were gram-negative bacilli (87.7%), 25 isolates were gram (+) pathogens (11.4%), and 2 (0.9%) isolates were Candida. Acinetobacter (n:80) and pseudomonas (n:71) were most isolated pathogens (78%). Acinetobacter and pseudomonas were most susceptible to Colistin (100%). In pulmonary ICU, gram negative pathogens were most isolates. Effective antibiotic should be according to gram negative pathogens as first choice in pulmonary ICU.
CIRCUMSCRIBED CORTICAL ATROPHY IN THE PRESENILE PSYCHOSES—PICK'S DISEASE
Authors: Charles Davison
Journal: American Journal of Psychiatry (1938)

Two cases of circumscribed cortical atrophy (Pick's disease) are described. The clinical differentiation of this affection from Alzheimer's disease and senile dementia is difficult. Histopathologically, there was atrophy of the left hemisphere in both instances; the temporal and the hippocampal convolutions showed the most extensive involvement. In the second case the atrophy also extended to the parietal convolutions. Practically all the cyto-architectural layers of the affected convolutions were distorted and the ganglion cells showed retrograde and other pathologic changes. In the second case the second and third cortical laminæ were more involved than the other layers. Of unusual interest in the first case were the atherosclerotic changes in the vessels of the left temporal lobe, the swelling and chromatolytic changes of the Purkinje cells of the cerebellum and of some of the nerve cells of the medulla oblongata. The various pathogenetic theories accounting for the production of this disorder are discussed.
Presence of a Mouse Mammary Tumor Virus-Related Antigen in Human Breast Carcinoma Cells and Its Absence From Normal Mammary Epithelial Cells2
Authors: Ning-Sun Yang, Charles M. McGrath, Philip Furmanski
Journal: JNCI Journal of the National Cancer Institute (1978)

Antigen(s) related to the major external glycoprotein (gp52) of mouse mammary tumor virus was detected in the human breast cancer cell line MCF-7. No such antigenic determinants were detectable in normal human mammary epithelial cells.
Rational combination treatment with histone deacetylase inhibitors and immunomodulatory drugs in multiple myeloma
Authors: T Hideshima, F Cottini, H Ohguchi, J Jakubikova, G Gorgun, N Mimura, Y-T Tai, N C Munshi, P G Richardson, K C Anderson
Journal: Blood Cancer Journal (2015)

Abstract Immunomodulatory drugs (IMiDs) thalidomide, lenalidomide (Len) and pomalidomide trigger anti-tumor activities in multiple myeloma (MM) by targetting cereblon and thereby impacting IZF1/3, c-Myc and IRF4. Histone deacetylase inhibitors (HDACi) also downregulate c-Myc. We therefore determined whether IMiDs with HDACi trigger significant MM cell growth inhibition by inhibiting or downregulating c-Myc. Combination treatment of Len with non-selective HDACi suberoylanilide hydroxamic acid or class-I HDAC-selective inhibitor MS275 induces synergic cytotoxicity, associated with downregulation of c-Myc. Unexpectedly, we observed that decreased levels of cereblon (CRBN), a primary target protein of IMiDs, was triggered by these agents. Indeed, sequential treatment of MM cells with MS275 followed by Len shows less efficacy than simultaneous treatment with this combination. Importantly ACY1215, an HDAC6 inhibitor with minimal effects on class-I HDACs, together with Len induces synergistic MM cytotoxicity without alteration of CRBN expression. Our results showed that only modest class-I HDAC inhibition is able to induce synergistic MM cytotoxicity in combination with Len. These studies may provide the framework for utilizing HDACi in combination with Len to both avoid CRBN downregulation and enhance anti-MM activities.
A prospective study of topical dimethyl sulfoxide for treating anthracycline extravasation.
Authors: I N Olver, J Aisner, A Hament, L Buchanan, J F Bishop, R S Kaplan
Journal: Journal of Clinical Oncology (1988)

Twenty patients with extravasation of anthracyclines were treated on a single-arm pilot study with topical 99% dimethyl sulfoxide (DMSO) and observed for 3 months with regular examinations and photographs. DMSO was applied to approximately twice the area affected by the extravasation and allowed to air dry. This was repeated every six hours for 14 days. The initial signs of extravasation included swelling in 17 patients, erythema in 15, and pain in 12. The median area of damage was 8.25 cm2 and a median of 25 minutes elapsed between extravasation and application of DMSO with one patient not treated until seven days postextravasation. Sixteen patients were observed for 3 months, two died of disease earlier after receiving 2 weeks of DMSO and three days of DMSO, respectively, and two were lost to follow-up having received one day and five days of DMSO. In no patient did extravasation progress to ulceration or require surgical intervention, suggesting with 95% confidence a true ulceration rate of between 1% and 17%. At 3 months there was no sign of residual damage in six patients, while a pigmented indurated area remained in ten. Two patients had a recall reaction with increased pain at the extravasation site when further intravenous (IV) doxorubicin was administered. The only toxicities of DMSO included a burning feeling on application subsequently associated with itch, erythema, and mild scaling. Blisters occurred in four patients. Six patients reported a characteristic breath odor associated with DMSO. Topical DMSO appears to be a safe and effective treatment for anthracycline extravasation.
Lipopolysaccharide-induced Alveolar Epithelial Permeability
Authors: XIAO YANG LI, KENNETH DONALDSON, WILLIAM MacNEE
Journal: American Journal of Respiratory and Critical Care Medicine (1998)

Intratracheal instillation of lipopolysaccharide (LPS) in the rat has been used as a model of acute lung inflammation. Among the early events in this process is a transient increase in airspace epithelial permeability which peaks 4 h after intratracheal instillation of LPS. The increased epithelial permeability is concomitant with the influx of neutrophils into the airspaces, peaking 8 h postinstillation. We have investigated the mechanism of this LPS-induced increase in epithelial permeability. The role of the neutrophil in LPS-induced epithelial permeability was assessed by pretreatment with neutrophil antibody to abolish neutrophil influx, which did not affect the increase in epithelial permeability. Because LPS instillation also induced increased tumor necrosis factor alpha (TNF-alpha) activity in bronchoalveolar lavage (BAL) fluid, and its release by cultured BAL leukocytes from treated animals, TNF-alpha antibody was coinstilled intratracheally with LPS in rats. TNF-alpha antibody eliminated TNF-alpha activity in BAL fluid, but had no effect on LPS-induced increased epithelial permeability. Increased levels of nitric oxide (NO), measured as nitrite, were also present in BAL fluid from LPS-treated rat lungs and LPS-elicited BAL leukocytes produced increased NO in culture. Treatment of rats with the specific NO synthase inhibitor L-NMMA significantly diminished the LPS-induced increased epithelial permeability. These data suggest that NO is involved in LPS-induced changes in epithelial integrity. However, other mechanisms should be evoked in addition to NO to explain completely the increased epithelial permeability produced by LPS.
Enhanced acute pulmonary inflammation and reduced fibrotic response in quartz-exposed p47phox-deficient mice
Authors: Catrin Albrecht, Damien van Berlo, Agnes Boots, Anton Wessels, Verena Wilhelmi, Agnes Scherbart, Kirsten Gerloff, Francois Huaux, Aalt Bast, Roel Schins
Journal: European Respiratory Journal (2011)

Previous studies have shown that quartz (crystalline silica) provides a useful tool to study experimental fibrosis in rodents. In the present study, we have investigated the involvement of phagocyte-derived reactive oxygen species (ROS) in quartz-induced inflammatory and fibrotic responses.  NADPH oxidase p47phox subunit deficient mice and their wild type counterparts were exposed to 100 mg/kg b.w. quartz via a single pharyngeal aspiration. After 24 hours markers of inflammation and oxidative stress were investigated in bronchoalveolar lavage fluid (BALF) and lung tissue. Quartz elicited a strong acute inflammatory response, characterised by a remarkably similar pulmonary influx of neutrophils in both strains. Interestingly, however, luminex multiplex analysis of BALF revealed stronger increases of interleukin (IL)-1β, IL-6, keratinocyte-derived chemokine (KC), monocyte chemoattractant protein-1 (MCP-1) and granulocyte colony stimulating factor (G-CSF) in the knockout mice compared to wild type animals. Differences in IL-4, IL-10, IL-13 and tumour necrosis factor-alpha (TNF-α) were not detectable. In contrast, pulmonary mRNA levels of the oxidative stress markers γ-glutamyl cysteine synthetase (γ-GCS) and heme oxygenase-1 (HO-1) were significantly enhanced only in the wild type mice in response to quartz-treatment. Three months after quartz treatment, significantly less fibrosis occurred in the lungs of knockout mice, as indicated by hydroxyproline content and Masson9s trichrome staining.  These data show that impairment of NADPH oxidase increases acute inflammatory responses, whereas it reduces oxidative stress and fibrosis in the lungs of quartz-exposed mice.
Early intervention in congenital cystic adenomatoid malformation (CCAM)
Authors: Hanna Dmenska, Dariusz Polnik, Ludmila Bacewicz, Piotr Kalicinski
Journal: European Respiratory Journal (2012)

The aim of the study is to present a group of pts with the final pathological diagnosis of CCAM operated on at our Institute between 2005 - 2011.   Materials and Methods : In total 22 pts underwent the operation (15 M, 7 F) at the gestational age 30-40 weeks (mean 37.9±1.6). 16 pts were born by Caesarean section. Birth weight was 1500g - 4880g (mean 3321g±503). The pts were asymptomatic, except 6, who presented respiratory distress syndrome. 19 pts diagnosed with CCAM prenatally between 20-33 gestational week (mean 23.5±2.6) were evaluated until delivery at tertiary care centres. This approach guaranteed an easy admission and immediate surgical treatment in our Institute. CT and angioCT were performed in all pts prior to operation to confirm diagnosis.   Results:  All pts underwent open lateral thoracotomy (18 pts/lobectomy, 4pts/ segmentectomy respectively). Age at intervention ranged 1-51 days (mean 10.6±7.2). CCAM localisation was: right lung lower lobe (7), left lung upper (6) and lower lobe (7). Generally no major postoperative complications were observed. Only 2 pts were reoperated for pneumothorax. Length of postoperative ventilation ranged 1-10 days (mean 2.1±1.1). Length of hospitalisation was 8-48 days (mean 19.4±6.5). All pts have been followed up at our Outpatients9 Clinic since operation. At present their ages range 0.3-6.4 yrs (mean 3.1±1.6). Development is normal. No increased number of respiratory infections is observed.   Conclusions:   1.Most CCAMs are diagnosed prenatally by means of routine USG analysis.  2.Early surgical treatment of CCAMs is safe and elective lobectomy appears to be very well tolerated.  3.Follow-up shows that early surgical intervention does not disturb development of those children.
Carbamazepine in manic-depressive illness: a new treatment
Authors: J C Ballenger, R M Post
Journal: American Journal of Psychiatry (1980)

The authors evaluated carbamazepine (Tegretol), a drug of choice for treatment of temporal lobe epilepsy, in a double-blind placebo-controlled trial in patients with manic-depressive illness. Seven of 9 manic patients had a partial to marked response; several also showed relapses when placebo was substituted and improvement when carbamazepine was reinstituted. Five of 13 depressed patients showed significant improvement in depression ratings; 3 additional patients experienced partial relapse when placebo was substituted. Carbamazepine might also have prophylactic as well as acute efficacy in patients with both phases of manic-depressive illness, including some patients who do not respond to lithium. Therapeutic effects were achieved with 600-1600 mg/day at blood levels of 8-12 microgram/ml with relatively few side effects. Carbamazepine may prove to be a useful additional treatment for affective illness.
Abstract 3022: Clopidogrel Improves Vascular Function and NT-proBNP Levels in Patients With Ischemic Cardiomyopathy
Authors: Volker Rudolph, Michael Klusmeier, Kai Mullerleile, Tanja K Rudolph, Anna Klinke, Kai Friedrichs, Denise Lau, Katalin Szoecs, Thomas Meinertz, Stephan Baldus
Journal: Circulation (2009)

Various in vitro and in vivo observations indicate vasoprotective actions of clopidogrel beyond its antiaggregatory effects. In this prospective, double-blind, randomized study we sought to evaluat...