Hypertension and Diabetes
Authors: Henry J. John
Journal: Annals of Internal Medicine (1932)

Article1 June 1932Hypertension and DiabetesHENRY J. JOHN, M.D., F.A.C.P.HENRY J. JOHN, M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-5-12-1462 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThat the blood pressure rises as a result of increase in weight in non-diabetic individuals has been shown by various authors.2, 14, 15, 16, 17, 18, 41 One striking example of this relationship is shown in the data reported by Hartman and Ghrist2 of the Mayo Clinic, who in 1922 analyzed a series of 2,042 consecutive cases of this type which were seen there. The males and females were practically equally divided. The summary of this study may be expressed by the following:Observations by Terry17and Rose18showed that in patients presenting hypertension with obesity, merely the reduction of...References1 RISEMANWEISS JES: The age and sex incidence of arterial hypertension, Am. Heart Jr., 1929, v, 172-190. CrossrefGoogle Scholar2 HARTMANGHRIST HRDG: Blood pressure and weight, Arch. Int. Med., 1929, xliv, 877-881. CrossrefGoogle Scholar3 MOHLER HK: Hypertension and hyperglycemia, Jr. Am. Med. Assoc., 1925, lxxxiv, 243-245. CrossrefGoogle Scholar4 WIECHMANN E: Die Entstehungsbedingungen der Zuckerkrankheit, Münch. med. Wchnsch., 1929, lxxvi, 98-101. Google Scholar5 ADAMS S: A study of the blood pressure of patients with diabetes mellitus, Am. Jr. Med. Sci., 1929, clxxvii, 195-201. CrossrefGoogle Scholar6 KOOPMAN J: Blood pressure and sugar metabolism, Endocrinology, 1924, viii, 340-346. CrossrefGoogle Scholar7 HITZENBERGER K: Über den Blutdruck bei Diabetes mellitus, Wien. Arch. f. inn. Med., 1921, ii, 461. Google Scholar8 KYLIN E: Hypertonie und Zuckerkrankheit, Zentralbl. f. inn. Med., 1921, xlii, 873-877. Google Scholar9 KATZ-KLEIN F: Diabetes und Hypertonie, Med. Klinik, 1924, ii, 1808-1811. Google Scholar10 PETERSON RF: The relation of hypertension and arteriosclerosis to diabetes mellitus. (Unpublished thesis, cited by Adams,5 1929.) Google Scholar11 KRAMER DW: Hypertension and diabetes, Am. Jr. Med. Sci., 1928, clxxvi, 23-31. CrossrefGoogle Scholar12 ROSENBLOOM J: Blood pressure studies in one hundred and forty cases of diabetes mellitus, Jr. Lab. and Clin. Med., 1922, vii, 392-399. Google Scholar13 ELLIOTT AR: A clinical study of blood pressure variations in diabetes and their bearing on the cardiac complications, Jr. Am. Med. Assoc., 1907, xlix, 27-30. CrossrefGoogle Scholar14 FABER HK: A formula expressing a general relationship between pressure and body weight, Proc. Soc. Exper. Biol. Med., 1927, xxv, 77-80. CrossrefGoogle Scholar15 SYMONDS B: The blood pressure of healthy men and women, Jr. Am. Med. Assoc., 1923, lxxx, 232-236. CrossrefGoogle Scholar16 HUBER EG: Systolic blood pressure of healthy adults in relation to body weight, Jr. Am. Med. Assoc., 1927, lxxxviii, 1554-1557. CrossrefGoogle Scholar17 TERRY AH: Obesity and hypertension, Jr. Am. Med. Assoc., 1923, lxxxi, 1283-1284. CrossrefGoogle Scholar18 ROSE RH: Weight reduction and its remarkable effect on high blood pressure, New York Med. Jr., 1922, cxv, 752-755. Google Scholar19 JOHN HJ: The relation of weight to diabetes, Endocrinology, 1930, xiv, 282-287. CrossrefGoogle Scholar20 LARSEN V: [Diabetes and hypertension], Ugesk. f. Laeger, 1929, xci, 695. Google Scholar21 MARAÑON G: Hipertensión y diabetes, Arch. cardiol. y hemat., 1922, iii, 125-131. Google Scholar22 HIRZENBERGERRICHTER-QUITTNER KM: Ein Beitrag zum Stoffwechsel bei der vaskulären Hypertonie, Wien. Arch. f. inn. Med., 1921, ii, 189-232. Google Scholar23 KYLIN E: High blood pressure and diabetes, Hygeia, 1922, lxxxiv, 49-56. Google Scholar24 JOSLIN EP: Arteriosclerosis and diabetes, Ann. Clin. Med., 1927, v, 1061-1141. Google Scholar25 THOMAS E: Researches expérimentales touchant l'influence de la cholestérine sur le développement de l'hypertension artérielle, Arch. d. mal. du coeur, 1926, xix, 641-646. Google Scholar26 LETULLELABBÉHEITZ MMJ: De la calcification des artères chez les diabetiques, Arch. d. mal. du coeur, 1927, xx, 577-597. Google Scholar27 FABER A: [Arteriosclerosis; calcification of vessels in man and animals], Ugesk. f. Laeger, 1926, lxxxviii, 433-438. Google Scholar28 EDITORIAL: Blood peptids and arterial hypertension, Jr. Am. Med. Assoc., 1927, lxxxix, 970. Google Scholar29 SHAPIRO S: Relation of certain glands of internal secretion to development of arteriosclerosis, Endocrinology, 1927, xi, 279-289. CrossrefGoogle Scholar30 EDITORIAL: The pathogenesis of hypertension; a new theory, Jr. Am. Med. Assoc., 1926, lxxxvii, 248. Google Scholar31 STRISOWER R: Insulin und Blutdruck, Wien. Arch. f. inn. Med., 1927, xiv. 429-434. Google Scholar32 HAHN L: [Diphasic action of insulin on blood pressure], Klin. Wchnschr., 1926, v, 1429. CrossrefGoogle Scholar33 BREMSHOLTEN AC: [Rise of blood pressure in certain so-called hyperglycemic cases after insulin injections], Bibliot. f. Laeger, 1929, clxxxi, 463-482. Google Scholar34 HERRICK WW: Hyperglycemia and hypertension, Jr. Am. Med. Assoc., 1923, lxxxi, 1942-1944. CrossrefGoogle Scholar35 KAHN M: Angina pectoris of diabetes, Jr. Am. Med. Assoc., 1921, lxxvi, 570. Google Scholar36 HÄRLE F: Hypertonie und Blutzucker, Ztschr. f. klin. Med., 1921, xcii, 124-133. Google Scholar37 WIECHMANN E: Hypertension und Blutzucker, Deutsch, Arch. f. klin. Med., 1928, clxi, 92-110. Google Scholar38 BORDLEYBAKER JBM: A consideration of arteriosclerosis of the cerebral vessels and the pathogenesis of hypertension, Bull. Johns Hopkins Hosp., 1926, xxxix, 229-264. Google Scholar39 ANREPSTARLING GVEH: Central and reflex regulation of circulation, Proc. Roy. Soc., 1924-1925, xcvii, Ser. B, 463-487. Google Scholar40 STARLING EH: The physiologic factors in hyperplasia, Brit. Med. Jr., 1925, ii, 1163-1165. Google Scholar41 GIBBES JH: Analysis of one hundred cases of hypertension, South. Med. Jr., 1926, xix, 413-416. CrossrefGoogle Scholar42 BARACH JH: Essential vascular hypertension, Jr. Am. Med. Assoc., 1922, lxxix, 2140-2143. CrossrefGoogle Scholar43 THOM BP: Syphilis and high blood pressure, Med. Rec., 1922, ci, 89-93. Google Scholar44 DAVIS NS: Arterial hypertension; its relationship to chronic intestinal disorders, Med. Clin. N. Am., 1923, vii, 547-553. Google Scholar45 NEWBURGHCLARKSON LHS: Renal injury produced in rabbits on diets containing meat, Arch. Int Med., 1923, xxxii, 850-869. CrossrefGoogle Scholar46 NUZUMOSBORNESANSUM FRMWD: Experimental production of hypertension, Arch. Int. Med., 1925, xxxv, 492-499. CrossrefGoogle Scholar47 MCCOLLUMPOLVOGTSIMMONDS SVLMN: Production of kidney lesions in rats by diets defective only in that they contain excessive amounts of proteins, Bull. Johns Hopkins Hosp., 1923, xxxiv, 168-172. Google Scholar48 MAJOR RH: Cause and treatment of arterial hypertension, Jr. Kansas Med. Soc., 1925, xxv, 177-179. Google Scholar49 MAJOR RH: Excretion of guanidine bases in two cases of arterial hypertension with reduction in blood pressure, Bull. Johns Hopkins Hosp., 1925, xxxvi, 357-360. Google Scholar50 MAJOR RH: Effects of hepatic extract on high blood pressure, Jr. Am. Med. Assoc., 1925, lxxxv, 251-253. CrossrefGoogle Scholar51 MACDONALD WJ: Extractives of liver possessing blood pressure reducing properties, Canad. Med. Assoc. Jr., 1925, xv, 697-701. Google Scholar52 JAMESLAUGHTON AANB: Control of blood pressure with liver extracts, Canad. Med. Assoc. Jr., 1925, xv, 701-702. Google Scholar53 OLIVERSCHÄFER GEA: On the physiological action of extracts of pituitary body and certain other glandular organs, Jr. Physiol., 1895, xviii, 277-279. CrossrefGoogle Scholar54 EDITORIAL: Lowering the blood pressure with liver extract, Jr. Am. Med. Assoc., 1925, lxxxv, 194-195. Google Scholar55 MAJOR RH: Relationship between certain products of metabolism and arterial hypertension, Jr. Am. Med. Assoc., 1924, lxxxiii, 81-84. CrossrefGoogle Scholar56 DALEDIXON HHWE: The action of pressure amines produced by putrefaction, Jr. Physiol., 1909, xxxix, 25-44. CrossrefGoogle Scholar57 BARGERDALE GHB: B-imitazolylethylamine, a depressor constituent of intestinal mucosa, Jr. Physiol., 1910-1911, xli, 499-503. Google Scholar58 HARVEY WH: Auto-intoxication and experimental nephritis in rabbits, Jr. Path. and Bact., 1912, xvi, 95-105. Google Scholar59 CLARK A: The clinical application of ergotamine (tyramine), Jr. Biochem., 1910, v, 236-242. Google Scholar60 WESTPHAL K: Untersuchungen zur Frage der Entstehungsbedingungen des genuinien arteriellen Hochdruckes. Ztsch. f. klin. Med., 1925, ci, 545-557. Google Scholar61 REID WD: Arterial hypertension, Boston Med. and Surg. Jr., 1925, cxcii, 883-890. CrossrefGoogle Scholar62 KYLIN E: Über die Einwirkung der Ca und K-ionen auf Pituitrin-Blutzucker-Reaktion, Klin. Wschnschr., 1925, iv, 2068. CrossrefGoogle Scholar63 POSTSTIEGLITZ WEEJ: Hypertension; clinical aspects of etiology and therapy, Am. Jr. Med. Sci., 1926, clxxi, 648-654. CrossrefGoogle Scholar64 SCHMIDTMANN M: Experimentelle Studien zur Pathogenese der Arteriosclerose, Virchow's Arch. f. path. Anat., 1922, ccxxxvii, 1-21. CrossrefGoogle Scholar65 ANITSCHKOW N: Über die experimentelle Atherosklerose der Aorta beim Meerschweinchen, Beitr. z. path. Anat. u, allg. Path., 1922, lxx, 265-281. Google Scholar66 MÖNCKEBERG JC: Arteriosklerose, Klin. Wchnschr., 1924, iii, 1473-1478. CrossrefGoogle Scholar67 SCHÖNHEIMER R: Über die experimentelle Cholesterin krankheit der Kaninchen, Virchows Arch. f. path. Anat., 1924, ccxlix, 1-42. CrossrefGoogle Scholar68 NUZUMSEEGARLGARLANDOSBORNE FRBRM: Arteriosclerosis and increased blood pressure, Arch. Int. Med., 1926, xxxvii, 733-744. CrossrefGoogle Scholar69 FRANK E: 1. Bestehen Beziehungen zwischen chromaffinem Hypertonie des Menschen? 2. Ein kritischer Beitrag zu der Lehre von der physio-pathologisch. 3. Bedeutung des Adrenalins, Deutsch. Arch. f. klin. Med., 1911, ciii, 397-412. Google Scholar70 O'HARE JP: Glucose tolerance test in chronic vascular hypertension, Am. Jr. Med. Sci., 1920, clx, 366. CrossrefGoogle Scholar71 HERRICK WW: Hypertension and hyperglycemia, Jr. Am. Med. Assoc., 1923, lxxxi, 1942-1944. CrossrefGoogle Scholar72 MOHLER HK: Hypertension and hyperglycemia; observations on a series of 46 cases, Jr. Am. Med. Assoc., 1925, lxxxiv, 243-245. CrossrefGoogle Scholar73 MEYERSKILLIAN VCJA: Studies in animal diastasis; the increased diastatic activity of the blood in diabetes and nephritis, Jr. Biol. Chem., 1917, xxix, 179-189. Google Scholar74 TACHAU H: Eine neue Methode der Bestimmung des Blutzuckergehaltes, Deutsch. Arch. f. klin. Med., 1911, cii, 597-605. Google Scholar75 PEISER F: Über den hypertonischen Diabetes, Klin. Wchnschr., 1927, vi, 1419-1423. CrossrefGoogle Scholar76 NEUBAUER E: Über Hyperglykämie bei Hochdrucknephritis und die Beziehungen zwischen Glykämie und Glykosurie beim Diabetes mellitus, Biochem. Ztschr., 1910, xxv, 284-295. Google Scholar77 PEARCEKEITH : Personal communication. Google Scholar78 VON NOORDENISAAC CHS: Die Zuckerkrankheit und ihre Behandlung, 1927. Julius Springer, Berlin. CrossrefGoogle Scholar79 MARAÑON G: Über Hypertonie und Zuckerkrankheit, Zentralbl. f. inn. Med., 1922, xliii, 169-176. Google Scholar80 HITZENBERGER K: Über den Blutdruck bei Diabetes mellitus, Wien. Arch. f. inn. Med., 1921, ii, 461-466. Google Scholar81 JOSLIN EP: The treatment of diabetes mellitus, 1928, Lea and Febiger, Philadelphia. Google Scholar82 JANEWAY TC: Important contributions to clinical medicine during the past thirty years from the studies of human blood pressure, Johns Hopkins Hosp. Bull., 1915, xxvi, 341-350. Google Scholar83 ELLIOTT AR: A clinical study of blood pressure variations in diabetes and their bearing on the cardiac complications, Jr. Am. Med. Assoc., 1907, xlix, 27-30. CrossrefGoogle Scholar84 HOPPE-SEYLER G: Beitrag zur Kenntniss der Beziehungen der Erkrankung des Pancreas und seiner Gefässe zum Diabetes mellitus, Deutsch. Arch. f. klin. Med., 1894, lii, 171-177. Über chronische Veränderungen des Pankreas bei Arteriosklerose und ihre Beziehung zum Diabetes mellitus, Deutsch. Arch. f. klin. Med., 1904, lxxxi, 119-162. Google Scholar85 HERXHEIMER G: Pankreas, Handbuch d. inn. Sekretion, ed. M. Hirsch, 1927, Curt Kabitzsch, Leipzig, i, 25-122. Google Scholar86 BILLIGHEIMER E: Über die Wirkungsweise der probatorischen Adrenalininjektion, Deutsch. Arch. f. klin. Med., 1921, cxxxvi, 1-32. Google Scholar87 KAHLER H: Zur Frage der Hyperglykämie bei Krankheitszuständen mit Hochdruck, Wien. Arch. f. inn. Med., 1922, iv, 129-148. Google Scholar88 PETRÉN : Cited by von Noorden and Isaac (l. c. 78). Google Scholar89 PEISER F: Über die Blutzuckerübertrittsschwelle bei Hypertonikern mit und ohne Diabetes, Ztschr. f. klin. Med., 1927, cvi, 290-309. Google Scholar90 VOEGELIN H: Über die Beziehung der Hypertonie zur Hyperglykämie, Deutsch. Arch. f. klin. Med., 1927, clvi, 178-181. Google Scholar91 WIECHMANN E: Zur Frage der Permeabilität der roten Blutkorperchen für Traubenzucker unter Besonderen Berücksichtigung des Diabetes, Ztschr. f. d. ges. exper. Med., 1924, xli, 462-492. CrossrefGoogle Scholar92 RYSER H: Der Blutzucker während der Schwangerschaft, der Geburt, im Wochenbett und bei den Schwangerschaftstoxikosen, Deutsch. Arch. f. klin. Med., 1916, cxviii, 408-461. Google Scholar93 GETTLERBACKER AOW: Chemical and physical analysis of blood in thirty normal cases, Jr. Biol. Chem., 1916, xxv, 211-222. CrossrefGoogle Scholar94 EPSTEINASCHNER AAPW: The effect of surgical procedures on the blood sugar content, Jr. Biol. Chem., 1916, xxv, 151-162. CrossrefGoogle Scholar95 STAUB H: Untersuchungen über den Zuckerstoffwechsel des Menschen, Ztschr. f. klin. Med., 1921, xci, 44-60. Google Scholar96 WIECHMANN E: Hypertension und Blutzucker, Deutsch. Arch. f. klin. Med., 1928, clxi, 92-110. Google Scholar97 FAHR T: Experimentelle Beiträge zur Frage des Pankreas-diabetes, Verhandl. d. deutsch, path. Gellesch., 1913, xvi, 289-294. Google Scholar98 ASCHOFF L: (Cited by Herxheimer, l. c. 85.) Google Scholar99 SEYFARTH C: Neue Beiträge zur Kenntnis der Langerhans'schen Inseln im menschlichen Pankreas und ihre Beziehung zum Diabetes mellitus, 1920, G. Fischer, Jena. Google Scholar100 FRAENKEL M: Die Bedeutung der Langerhans'schen Inseln in ihrer Stellung zum übrigen Pankreas-gewebe und ihre Beziehung zum Diabetes, Würzb. Abhandl. a. d. Gesamtgeb. d. prak. Med., 1908, viii, 269-290. Google Scholar101 JOHN HJ: A study of 1,100 glucose tolerance tests, Med. Jr. and Rec., 1930, cxxxi, 287-292, 351-354, 398-402. Google Scholar102 RIESMAN D: Hypertension in women, Jr. Am. Med. Assoc., 1919, lxxiii, 330. CrossrefGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Cleveland, Ohio*Received for publication, September 10, 1931.†From The Cleveland Clinic, Cleveland, Ohio. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byGestational diabetes mellitus among African-American womenEpidemiology of Hypertension and Diabetes MellitusThe ethnic prevalence of hypertension in a diabetic clinicPulse pressure—I. Level and associated factors in four Chicago epidemiologic studiesPulse pressure—II. Factors associated with follow-up values in three Chicago epidemiologic studiesMultivariate analysis of the relationship of six variables to blood pressure: Findings from Chicago Community Surveys, 1965–1971VASCULAR DISEASE IN A DIABETIC CLINICTHE RELATION OF HYPERPLASTIC ARTERIOSCLEROSIS TO DIABETES MELLITUS*ELI MOSCHCOWITZ, M.D.Acceptability of Vegetables in an Army Mess1Erbbiologie und Erbpathologie des KreislaufapparatesErbbiologie und Erbpathologie des Kreislaufapparates 1 June 1932Volume 5, Issue 12Page: 1462-1486KeywordsBlood pressureHypertensionObesityResearch design ePublished: 1 December 2008 Issue Published: 1 June 1932 PDF downloadLoading ...