tbuckley/cabot-search huggingface dataset:
Abstract 1605: T-Type Calcium Current Activates Pro-Survival Signaling Pathways after Myocardial Infarction
Authors: Naser Jaleel, Hajime Kubo, Erhe Gao, Scott MacDonnell, Xiongwen Chen, Hiroyuki Nakayama, David Angert, Timothy Flynn, Remus Berretta, Hongyu Zhang, Walter Koch, Jeffery Molkentin, Steven Houser
Journal: Circulation (2008)

Ca 2+ influx through L-type Ca 2+ channels (I Ca,L ) is essential for cardiac contraction and for activation of a variety of Ca 2+ dependent signaling pathways. However, Ca 2+ can also enter cardiac myocytes through T-type Ca 2+ channels (TTCCs), which are found in the fetal heart and become re-expressed in adult ventricular myocytes (VMs) during cardiac pathology. While excess I Ca,L promotes VM death and dysfunction, the role of Ca 2+ influx through TTCCs (I Ca,T ) in cardiac stress responses is unknown and is the topic of this study. METHODS: Transgenic (TG) mice with inducible, cardiac-specific expression of α1G-TTCCs and control (CTR) mice were used. Myocardial infarction (MI) was induced by permanent ligation of the left anterior descending coronary artery. Mice were sacrificed at 1 week and 7 weeks post-MI. RESULTS: TG hearts had greater in vivo fractional shortening (FS) than CTR (TG: 39.6±3.2%, N=16 vs CTR: 32.2±1.2%, N=14; p&lt;0.05). VMs isolated from TG hearts showed peak I Ca,T of −32.8±3.0 pA/pF. I Ca,L was smaller in TG than in CTR VMs (−9.6±0.7 pA/pF vs −12.0±0.4 pA/pF, p&lt; 0.05). Compared to I Ca,L , I Ca,T triggered smaller Ca 2+ transients (1.5±0.1 vs 2.1±0.1, n=10; p&lt;0.01) and contractions (2.6±0.7% vs 8.7±1.2%, n=10; p&lt;0.01). Despite higher Ca 2+ influx than CTR hearts, TG hearts showed no cardiac histopathology or premature death, and TG hearts had higher levels of phosphorylated Akt (p&lt;0.05) and dephosphorylated NFAT (p&lt;0.05), which are known to be cytoprotective. After 1 week of MI, TG and CTR hearts displayed similar reductions in FS (25.3±1.7%, N=14 vs 25.7±1.8%, N=19) and increases in cardiac size (HW/BW, mg/g: 4.4±0.1, N=14 vs 4.5±0.3, N=19). However, TG hearts had smaller infarcts than CTR hearts (19.9±1.8%, N=7 vs 28.4±2.3%, N=6, p&lt;0.01). At 7 weeks post-MI, TG mice showed a higher survival rate than CTR mice (66.7% vs 47.6%). Also, at 7 weeks post-MI, TG hearts were larger than CTR (HW/BW: 10.4±1.0, N=12 vs 7.7±0.5, N=10; p&lt;0.05) and had similar FS to CTR hearts (28.7±2.7, N=8 vs 28.0±2.8) and isolated VM contractility (TG: 5.6±0.7%, n=15 vs CTR: 5.3±0.5%, n=14). CONCLUSION: Ca 2+ influx via TTCCs has small effects on cardiac contraction, but is associated with reduced infarct size and increased survival, suggesting that it induces cytoprotective signaling. This research has received full or partial funding support from the American Heart Association, AHA Great Rivers Affiliate (Delaware, Kentucky, Ohio, Pennsylvania &amp; West Virginia).
Abstract 17292: Long QT Syndrome Variant 3 Patient Derived Induced Pluripotent Stem Cells: Novel and Critical Platform for Drug Screening
Authors: Cecile Terrenoire, George K Wang, Gordon Keller, Darrell N Kotton, Robert S Kass
Journal: Circulation (2011)

Congenital LQTS is a heritable family of arrhythmias caused by mutations in 12 genes coding for ion channels or ion channel associated proteins. Variant 3 (LQT-3) is caused by mutations in SCN5A, the gene coding for the α subunit of the primary cardiac Na+ channel. Based primarily on studies in heterologous expression systems, a mutation-specific pharmacology has proven useful in which drugs such as Mexiletine that preferentially inhibit mutation-induced late Na+ channel current (INaL), have been shown to be effective as therapeutic agents in the treatment of LQT-3. Here we isolated cardiomyocytes derived from human induced pluripotent stem cells (hiPSC-CMs) produced by lentiviral reprograming of skin fibroblasts from three individuals in a LQT-3 family: a proband carrying a de novo SCN5A mutation (INa_F1473C) and the proband's parents who carried wild type (WT) Na+ channels. Whole-cell patch clamp recordings were used to characterize INa properties in the three subjects: INa_F1473C channels failed to completely inactivate during 100ms-depolarizing pulses (INaL) in the action potential plateau voltage range, and were characterized by steady state inactivation that was significantly shifted in the depolarizing direction compared with WT channels. These properties agree well with those determined previously of the same mutation in HEK293 cells and are consistent with mutation-induced QT interval prolongation in the proband. Based on HEK cell experiments, we previously reported that mutation-induced Na+ channel dysfunction was corrected by 50 µM Mexiletine, a result confirmed for the mutant channels expressed in hiPSC-CMs. However, we find that the same Mexiletine concentration significantly inhibits two off target channel currents ICaL and IKr, results that could not be obtained from heterologous expression studies. These results, establish the critical importance of hiPSC-CMs not only as mechanistic models of channelopathies such as LQTS, but as important and unique platforms for screening drugs, for both effectiveness in correcting mutation-induced dysfunction and also for target specificity.
Abstract 18097: Predictors of Non-adherence with Guidelines for Antithrombotic Treatment and Subsequent Prognosis in Patients with Atrial Fibrillation.
Authors: Laurent Fauchier, Laurent Gorin, Emilie Nonin, Anne Bernard, Bernard Charbonnier, Dominique Babuty
Journal: Circulation (2010)

In atrial fibrillation (AF), ‘non-adherence’ to guidelines for antithrombotic treatment and undertreatment are likely to be associated with a worse prognosis in declarative surveys. Our objective w...
Other scientific purposes, other methodological ways
Authors: Marie-Paule Lecoutre, Bruno Lecoutre
Journal: Behavioral and Brain Sciences (2001)

Hertwig and Ortmann have made a laudable effort to bring together experimental practices in economics and in psychology. Unfortunately, they ignore one of the primary objectives of psychological research, which is an analytic description of general cognitive processes. Among experimental practices in probability judgment tasks they discussed, we will focus hereafter on enactment of scripts and repetition of trials.
The Negative Impact of Incomplete Angiographic Revascularization on Clinical Outcomes and Its Association With Total Occlusions
Authors: Vasim Farooq, Patrick W. Serruys, Hector M. Garcia-Garcia, Yaojun Zhang, Christos V. Bourantas, David R. Holmes, Michael Mack, Ted Feldman, Marie-Claude Morice, Elisabeth Ståhle, Stefan James, Antonio Colombo, Roberto Diletti, Michail I. Papafaklis, Ton de Vries, Marie-angèle Morel, Gerrit Anne van Es, Friedrich W. Mohr, Keith D. Dawkins, Arie-Pieter Kappetein, Georgios Sianos, Eric Boersma
Journal: Journal of the American College of Cardiology (2012)
Inverse relationship of peripheral thyrotropin-stimulating hormone levels to brain activity in mood disorders
Authors: L B Marangell, T A Ketter, M S George, P J Pazzaglia, A M Callahan, P Parekh, P J Andreason, B Horwitz, P Herscovitch, R M Post
Journal: American Journal of Psychiatry (1997)

The author's goal was to investigate relationships between peripheral thyroid hormone levels and cerebral blood flow (CBF) and cerebral glucose metabolism in affectively ill patients.Medication-free inpatients with major depression or bipolar disorder were studied with oxygen-15 water and positron emission tomography (PET) to measure CBF (N = 19) or with [18F] fluorodeoxyglucose and PET to measure cerebral glucose metabolism (N = 29). Linear regression was used to correlate global CBF and cerebral glucose metabolism with serum thyrotropin-stimulating hormone (TSH), triiodothyronine (T3), thyroxine (T4), and free T4 concentrations. Statistical parametric mapping was used to correlate regional CBF and cerebral glucose metabolism with these thyroid indexes. Post hoc t tests were used to further explore the relationships between serum TSH and global CBF and cerebral glucose metabolism.Serum TSH was inversely related to both global and regional CBF and cerebral glucose metabolism. These relationships persisted in the cerebral glucose metabolism analysis and, to a lesser extent, in the CBF analysis after severity of depression had been controlled for. In contrast, no significant relationships were observed between T3, T4, or free T4 and global or regional CBF and cerebral glucose metabolism.These data suggest that peripheral TSH (putatively the best marker of thyroid status) is inversely related to global and regional CBF and cerebral glucose metabolism. These findings indicate relationships between thyroid and cerebral activity that could provide mechanistic hypotheses for thyroid contributions to primary and secondary mood disorders and the psychotropic effects of thyroid axis manipulations.
Sacred cows: Clinical governance
Authors: Neville W Goodman
Journal: BMJ (1998)

Every so often, and seemingly increasingly often, a new “Big Idea” reaches the NHS. The BMJ issue that celebrated the NHS’s 50th anniversary contained an essay by Gabriel Scally and Liam Donaldson about the latest: clinical governance.1 This Big Idea is different: unlike previous ones it has no intuitive meaning. Ironically, the word governance in the sense intended (“The manner in which something is governed or regulated; method of management, system of regulations”) is marked as obsolete in the Oxford English Dictionary,2 which gives a quote from 1660: “To enquire of the Foundation, Erection, and Governance of Hospitals.”
Grading quality of evidence and strength of recommendations
Authors: David Atkins, Dana Best, Peter A Briss, Martin Eccles, Yngve Falck-Ytter, Signe Flottorp, Gordon H Guyatt, Robin T Harbour, Margaret C Haugh, David Henry, Suzanne Hill, Roman Jaeschke, Gillian Leng, Alessandro Liberati, Nicola Magrini, James Mason, Philippa Middleton, Jacek Mrukowicz, Dianne O'Connell, Andrew D Oxman, Bob Phillips, Holger J Schünemann, Tessa  Tan-Torres Edejer, Helena Varonen, Gunn E Vist, John W Williams, Stephanie Zaza
Journal: BMJ (2004)

GRADE Working Group (oxman{at}online.no)Informed Choice Research Department, Norwegian Health Services Research Centre, PO Box 7004, St Olavs Plass, 0130 Oslo, NorwayCorrespondence to: Andrew D Oxman,Accepted 5 March 2004
Rise in Drug-Resistant Gonorrhea Cases
Authors: Joan Stephenson
Journal: JAMA (2004)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Abstract 11890: Defining the Role of p62 in Cardiac Hypertrophy and Pathology
Authors: Mannix Auger Messier, Khosrow Rezvani, Jeffrey Robbins, Scott Pattison
Journal: Circulation (2012)

Introduction: Accumulation of ubiquitinated proteins and aggregates are increasingly being recognized as playing major roles in cardiac disease and heart failure. Recent work suggests that a protein named p62 plays a regulatory role in the accumulation of ubiquitinated proteins and protein aggregates. Chronic hemodynamic stress causes cardiac hypertrophy and triggers a concomitant increase in p62 and ubiquitinated protein levels. Hypothesis: p62 expression contributes to proteotoxic accumulation and cardiac hypertrophy. Methods: An adenovirus was created to drive p62 expression in neonatal cardiomyocytes to study role of p62 in cardiac cell growth and proteotoxic accumulation. Trans-aortic constriction or sham surgeries were performed on wild-type and p62-deficient mice to test if p62 was necessary for pressure-overload induced hypertrophy and pathology. Results: Overexpression of p62 in cardiomyocytes significantly increased cardiomyocyte size and caused a corresponding increase in aggregate accumulation...
Cryptosporidium outbreak linked to interactive water feature, UK: importance of guidelines
Authors: M Jones, D Boccia, M Kealy, B Salkin, A Ferrero, G Nichols, J M Stuart
Journal: Eurosurveillance (2006)

A need for national guidelines relating to interactive water features was highlighted following three outbreaks of cryptosporidiosis in the United Kingdom, all of which were related to public water features. In August 2003 the Health Protection Agency South West of England was notified of an outbreak of cryptosporidiosis associated with an interactive water feature designed for water play within an adventure park. The water feature was implicated following samples with a high coliform count and the presence of faecal coliforms. A case was defined as any child (younger than 16 years of age) who had visited the park during August and who subsequently had gastrointestinal symptoms and a faecal sample positive for cryptosporidium. Seventy one children were identified in the cohort. This outbreak of cryptosporidiosis was characterised by a very high attack rate (89%), relatively severe in duration (median 8 days) and had a relatively high hospital admission (16% of cases). The epidemic curve was consistent with a point source of infection, which corresponded to the date 80% of the cohort visited the park. This outbreak has similarities to two other cryptosporidiosis outbreaks reported in England in 2003 that involved public water features. These outbreaks raise issues about the operation and maintenance of water-based recreational attractions that very often involve children. The paper reflects on the basic control measures that can be taken and highlights the need for guidelines, especially since such attractions are becoming increasingly common. The Pool Water Treatment Advisory Group in United Kingdom has now produced guidelines.
Creativity and mental illness
Authors: Zoltán Rihmer, Xénia Gonda, Annamária Rihmer
Journal: American Journal of Psychiatry (1995)

It has been known for a long time that people with salient social and artistic creativity suffer more frequently from psychiatric illnesses than the average population. In their review paper, the authors assess the Hungarian and international scientific literature regarding the association of creativity and psychopathology. They conclude that contrary to the concept prevailing in the first part of the 20th century about the strong association between schizophrenia and creativity, the results of empirical research now unambiguously suggest that prominent social and artistic creativity is associated primarily with affective, and more specifically with bipolar affective illnesses. In addition, we already know that as regards the development of creativity, it is not the given affective (depressive, manic, hypomanic) episode which is important, but the hyperthymic or cyclothymic temperament structure which also predisposes for affective illness.
Chemical structure of mutagens and carcinogens and the relationship with biological activity.
Authors: R Benigni
Journal: Journal of experimental & clinical cancer research (2004)

Chemical carcinogenicity has been the target of numerous attempts to create predictive models alternative to the animal ones, ranging from short-term biological assays (e.g. mutagenicity tests) to theoretical models. Among the theoretical models, the application of the science of Structure-Activity Relationships (SAR) has earned special prominence. SAR has been applied both in a qualitative way (for example as simple recognition of suspected sub-structures or Structural Alerts), and in a quantitative way (Quantitative SAR, QSAR) to build mathematical models linking the physical chemical or structural properties of the molecules to the toxicological endpoints. This paper summarizes the contribution that the two approaches can provide in different situations. It concludes that the study of the structure of the chemicals generates predictions with limited reliability for the individual chemicals, however it has been demonstrated to be an extremely powerful tool for priority setting relative to large samples of chemicals.
Complications of TUR of the Bladder Neck in the Female
Authors: B.N.S. Bhatnagar, R.W. Barnes
Journal: Endoscopy (1984)

Transurethral resection of the bladder neck in the female is unpopular because of complications and indifferent results. This retrospective study of 238 procedures (carried out over the period 1940-72) documents the various complications and shows that the fears generally held are exaggerated. Most complications are of moderate incidence and can be easily and satisfactorily managed. The incontinence rate (4.7% in this study) can be further reduced by selection of cases after careful urodynamic evaluation and avoiding certain types of cases. It is related more to the type of patient than to the procedure itself.
Tetrahydrobiopterin Rescues Mice Lacking Beta-3 Adrenergic Receptors From Adverse Cardiac Remodeling Following Pressure Overload
Authors: Jordan S Leyton-Mange, Xiaolin Niu, Ronghua Yang, An L Moens, Karen L Miller, Ashley B Hale, Djahida Bedja, Kathleen L Gabrielson, Keith M Channon, David A Kass, Lili A Barouch
Journal: Circulation (2009)
Interim Analysis Of An Ongoing PHASE II Trial Assessing Safety and Efficacy Of Lenalidomide Maintenance In Patients With Chemosensitive Relapse Of Diffuse Large B-CELL Lymphoma (DLBCL)
Authors: Silvia Govi, Marta Bruno Ventre, Francesco Zaja, Alice Di Rocco, Michele Spina, Daniele Vallisa, Lydia Scarfo', Marianna Chiozzotto, Rosanna Cuccurullo, Angelo Fama, Andrés J.M. Ferreri
Journal: Blood (2013)
Ovarian cancer treatment in black and white women: A comparison of clinico-pathologic factors and outcome
Authors: S. M. Temkin, E. Lengyel, A. Tergas, M. Terplan
Journal: Journal of Clinical Oncology (2008)

16531 Background: Racial disparities have been identified at all points along the cancer continuum. It is unclear how biology, social determinants, access, and health care systems interact and contribute to disparities. We evaluated patterns of care and outcomes among women with epithelial ovarian cancer treated at a single specialty academic center in order to focus on racial differences in treatment and survival among a group of women who because of the center where they were treated, should all have had equal access to state-of-the art medical care. Our hypothesis was that equal treatment would result in equal outcomes. Methods: Demographic and clinical- pathologic information from the University of Chicago Ovarian Cancer Database from 1992 until the present was analyzed. Continuous variables were analyzed with t tests and categorical variables were analyzed with chi square tests. Differences in survival between the two groups were represented using Kaplan-Meier methods and analyzed using log rank tests. Results: We identified 209 women with invasive ovarian cancer, 163 (78%) white and 46 (22%) black. There was no difference between the groups in terms of age or family history of gynecologic malignancy. Disease stage, histology, grading, preoperative and postoperative CA-125 levels were similar between the racial groups. There was no difference in rates of optimal debulking (<1 cm residual tumor) or platinum sensitivity. Survival analysis displayed no difference in time to recurrence or overall survival between black and white patients. For black women, the median overall survival was 37.2 months (95% Confidence Interval (CI): 22.5, 52.9) while it was 34.1 months (95% CI: 27.4, 42.6) for white women. Conclusions: There is no evidence of a racial difference in either treatment or survival for ovarian cancer patients in our single institution review. Single institution reviews are helpful in pinpointing the origin of racial disparities along the cancer continuum. If equal treatment results in equal outcomes, then sources of disparities must be sought in the unequal distribution and quality of healthcare in the United States. No significant financial relationships to disclose.
LARG at chromosome 11q23 has functional characteristics of a tumor suppressor in human breast cancer
Authors: Danny C.T. Ong, Christina Rudduck, Koei Chin, Wen-Lin Kuo, Daniel K.H. Lie, Constance L.M. Chua, Chow Yin Wong, Ga Sze Hong, Joe Gray, Ann S.G. Lee
Journal: Cancer Research (2008)

Deletion of 11q23-q24 is frequent in a diverse variety of malignancies, including breast and colorectal carcinoma, implicating the presence of a tumor suppressor gene at that chromosomal region. We show here that LARG, from 11q23, has functional characteristics of a tumor suppressor. We examined a 6-Mb region on 11q23 by high-resolution deletion mapping, utilizing both loss of heterozygosity (LOH) analysis and microarray comparative genomic hybridization (CGH). LARG (also called ARHGEF12), identified from the analyzed region, was underexpressed in 34% of primary breast carcinomas and 80% of breast cancer cell lines including the MCF-7 line. Multiplex ligation-dependent probe amplification on 30 primary breast cancers and six breast cancer cell lines showed that LARG had the highest frequency of deletion compared to the BCSC-1 and TSLC1 genes, two known candidate tumor suppressor genes from 11q. In vitro analysis of breast cancer cell lines that underexpress LARG showed that LARG could be reactivated by trichostatin A, a histone deacetylase inhibitor, but not by 5-Aza-2{prime}-deoxycytidine, a demethylating agent. Bisulfite sequencing and quantitative high-throughput analysis of DNA methylation confirmed the lack of CpG island methylation in LARG in breast cancer. Restoration of LARG expression in MCF-7 cells by stable transfection resulted in reduced proliferation and more » colony formation, suggesting that LARG has functional characteristics of a tumor suppressor gene. « less
Reduced turn-around time for Mycobacterium tuberculosis drug susceptibility testing with a proportional agar microplate assay
Authors: V.A.T. Nguyen, H.Q. Nguyen, T.T. Vu, N.A.T. Nguyen, C.M. Duong, T.H.T. Tran, H.V. Nguyen, D.A. Dang, A.-L. Bañuls
Journal: Clinical Microbiology and Infection (2015)
Abstract 15977: Associations of Cardiorespiratory Fitness With Markers of Thrombosis and Inflammation in the Coronary Artery Risk Development in Young Adults Study
Authors: Natalie S Evans, Donald M Lloyd-Jones, David Green, Laura A Colangelo, David R Jacobs, Na Zhu, Claude Bouchard, Cora E Lewis, Pamela J Schreiner, Stephen Sidney, Barbara Sternfeld, Mercedes R Carnethon
Journal: Circulation (2011)

Background: Cardiorespiratory fitness (CRF) is inversely associated with markers of thrombosis and inflammation in cross-sectional studies. To determine the temporal association between these cardi...
The Treatment of Perianal and Anal Condylomata Acuminata: A new Operative Technique
Authors: James P S Thomson, Roger H Grace
Journal: Journal of the Royal Society of Medicine (1978)

Seventy-five patients have been treated for condylomata acuminata by means of a new operative approach which results in the preservation of the maximum amount of normal tissue. The technique has proved to be simple to perform, it has minimal complications and causes the patient little in the way of discomfort. Three out of 4 patients treated have no significant recurrent wart formation.