tbuckley/cabot-search huggingface dataset:
Abstract 13539: Physiological Basis of Discordance Between Coronary Flow Reserve and Hyperemic Microvascular Resistance to Evaluate Coronary Microvascular Dysfunction in Patients Without Atherosclerotic Obstruction
Authors: Kenshi Yamanaga, Kenichi Tsujita, Naohiro Komura, Kenji Sakamoto, Masanobu Ishii, Noriaki Tabata, Takashi Miyazaki, Tomonori Akasaka, Yuichiro Arima, Takamichi Ono, Sunao Kojima, Shinji Tayama, Koichi Kaikita, Seiji Hokimoto, Sunao Nakamura, Hisao Ogawa
Journal: Circulation (2014)

Introduction: Although coronary flow reserve (CFR) has been the only physiological way to evaluate the coronary microvascular (MV) function until recently, hyperemic MV resistance (hMR) have been developed as a newer modality measuring directly coronary MV function. Discordance between CFR and hMR may reflect various coronary hemodynamic situations. Hypothesis: Simultaneous measurement of CFR/hMR in pts without coronary obstruction could provide us deeper appreciation of hemodynamic functional alterations in coronary microvasculature. Methods: In 44 pts without coronary stenosis (diameter stenosis &gt;50%), CFR and hMR were measured utilizing a dual sensor (Doppler velocity and pressure)-equipped guidewire. To evaluate coronary MV hemodynamics, pts were categorized into four CFR/hMR quadrants using a cutoff values of CFR≥2.0 and hMR&lt;1.7 (median value of all study subjects) (Figure). Results: Discordance results between CFR/hMR was present in 39% of patients (17 of 44), with CFR≥2.0 and hMR≥1.7 in 30% (13 of 44) and CFR&lt;2.0 and hMR&lt;1.7 in 9% (4 of 44). There were significantly negative correlation between hMR and hyperemic average peak velocity (APV) (r=-0.73, p&lt;0.0001), CFR and baseline APV (r=-0.66, p&lt;0.001) despite no correlation between CFR and hyperemic APV (r=0.25, p=0.1). Baseline APV and hyperemic APV were significantly different among these groups (baseline APV; group 2 vs. group 3, 12.0±5.7 vs. 30.5±7.2, p=0.02, group 2 vs. group 4, 12.0±5.7 vs. 21.3±8.5, p=0.002, hyperemic APV; group 1 vs. group 4; 51.2±10.4 vs. 28.7±10.2, p&lt;0.0001, group 1 vs. group 2, 51.2±10.4 vs. 32.5±13.6, p=0.03). Four CFR/hMR quadrants thus represent 4 different types of coronary blood flow-perfusion pressure relationship (Figure). Conclusions: In pts without coronary obstruction, CFR was related to coronary autoregulation state and hMR to hyperemic state. Simultaneous CFR/hMR measurement might provide new physiological insight about coronary MV hemodynamics.
Clinical and Hemodynamic Outcomes up to 7 Years After Transcatheter Pulmonary Valve Replacement in the US Melody Valve Investigational Device Exemption Trial
Authors: John P. Cheatham, William E. Hellenbrand, Evan M. Zahn, Thomas K. Jones, Darren P. Berman, Julie A. Vincent, Doff B. McElhinney
Journal: Circulation (2015)

Background— Studies of transcatheter pulmonary valve (TPV) replacement with the Melody valve have demonstrated good short-term outcomes, but there are no published long-term follow-up data. Methods and Results— The US Investigational Device Exemption trial prospectively enrolled 171 pediatric and adult patients (median age, 19 years) with right ventricular outflow tract conduit obstruction or regurgitation. The 148 patients who received and were discharged with a TPV were followed up annually according to a standardized protocol. During a median follow-up of 4.5 years (range, 0.4–7 years), 32 patients underwent right ventricular outflow tract reintervention for obstruction (n=27, with stent fracture in 22), endocarditis (n=3, 2 with stenosis and 1 with pulmonary regurgitation), or right ventricular dysfunction (n=2). Eleven patients had the TPV explanted as an initial or second reintervention. Five-year freedom from reintervention and explantation was 76±4% and 92±3%, respectively. A conduit prestent and lower discharge right ventricular outflow tract gradient were associated with longer freedom from reintervention. In the 113 patients who were alive and reintervention free, the follow-up gradient (median, 4.5 years after implantation) was unchanged from early post-TPV replacement, and all but 1 patient had mild or less pulmonary regurgitation. Almost all patients were in New York Heart Association class I or II. More severely impaired baseline spirometry was associated with a lower likelihood of improvement in exercise function after TPV replacement. Conclusions— TPV replacement with the Melody valve provided good hemodynamic and clinical outcomes up to 7 years after implantation. Primary valve failure was rare. The main cause of TPV dysfunction was stenosis related to stent fracture, which was uncommon once prestenting became more widely adopted. Clinical Trial Registration— URL: http://www.clinicaltrials.gov . Unique identifier: NCT00740870.
Clinical analysis of 32 cases of biopsy-proven secondary organizing pneumonia following community-acquired pneumonia
Authors: Sung-Kyoung Kim, Chan Kwon Park, Ki Hoon Park, Ju Sang Kim, Joong Hyun Ahn, Soon Seog Kwon, Chi Hong Kim
Journal: European Respiratory Journal (2014)

Objective: To analysis the clinical characteristics of biopsy-proven secondary organizing pneumonia (SOP) during treatment for community-acquired pneumonia (CAP). Method: Among patients admitted with CAP as an initial diagnosis, 32 patients of biopsy-proven SOP during treatment were reviewed retrospectively. Results: There were 30 males and 2 females, with a mean age of 64.93±13.37 years. Initial computed tomography (CT) findings were as follows: lobar consolidation (n=12), patchy consolidation (n=10), mass-like consolidation (n=5), nodular consolidation (n=4), and bronchopneumonic infiltration (n=1). These lesions were combined with ground glass opacity (GGO) in 24 cases, including 8 cases of extensive GGO. All 5 cases of mass-like consolidation showed perilesional GGO. All patients showed good clinical course (defervescence, decreased WBC count and CRP level, and radiologic improvement) in early several days. However, there was no further radiologic improvement from hospital day (HD) 8.56±4.73 and, biopsy was performed on HD 9.52±4.54. Steroid was added on antibiotic therapy with pathologic confirmation, and follow-up X-ray showed gradual improvement. There was no relapse in follow-up X-ray on 3 months later after treatment completion. Conclusion: SOP should be included in differential diagnosis of no further improvement on serial radiologic follow-up despite of defervescence and decreased WBC count and CRP level during CAP treatment, especially if initial CT findings show consolidation combined with GGO or mass-like consolidation with perilesional GGO. For more clear clarification of SOP, further prospective study of large scale is required.
Worldwide Disparities in Surgical Care
Authors: M. J. Friedrich
Journal: JAMA (2015)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Copyright and Bedside Cognitive Testing
Authors: John C. Newman
Journal: JAMA Internal Medicine (2015)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Internal Medicine HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Internal Medicine journal
Salome With the Head of St John the Baptist
Authors: M. Therese Southgate
Journal: JAMA (1999)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The Effect of Cholecystectomy On Gastric Acidity
Authors: Howard R. Hartman, Andrew B. Rivers
Journal: Annals of Internal Medicine (1928)

Article1 February 1928The Effect of Cholecystectomy On Gastric AcidityHOWARD R. HARTMAN, M.D., ANDREW B. RIVERS, M.D.HOWARD R. HARTMAN, M.D.Search for more papers by this author, ANDREW B. RIVERS, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-1-8-558 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptMuch has been written concerning the influence of the various diseases of the gallbladder on gastric acidity, and it has usually been contended that there is a tendency to lowered acid values in such cases. There are many factors, both physiologic and pathologic, that influence gastric acidity. So true is this that at the Mayo Clinic we have come to regard only the extremes in acid values as significant, and even at these we are inclined to look askance. The physiologic variations may be wide, or certain transient unimportant pathologic processes exert a powerful influence on gastric acidity. Migraine frequently...Bibliography(1) FRIEDENWALD J: Presence of free hydrochloric acid in gastric contents in carcinoma of stomach. Jour. Am. Med. Assn., 1924, lxxxiii, 265-266. CrossrefGoogle Scholar(2) HARTMAN HR: The prevalence of free hydrochloric acid in cases of carcinoma of the stomach. Am. Jour. Med. Sc., 1922, clxiii, 186-190. CrossrefGoogle Scholar(3) MEYERIVYMCENERY JACET: The effect of cholecystectomy on gastric secretion. Arch. Int. Med., 1924, xxxiv, 129-135. CrossrefGoogle Scholar(4) ROST F: Translation by Reimann, S. P.; The pathological physiology of surgical diseases. Philadelphia, Blakiston's Son and Co., 1923, p. 136. Google Scholar(5) DE TAKATS G: Cholecystectomy for hyperacidity. Surg., Gynec. and Obst., 1925, xl, 221-223. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Division of Medicine Mayo Clinic Rochester, Minnesota*Submitted for publication January 25, 1928. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byKlinische und experimentelle Untersuchungen zur Proteolyse des operierten MagensPhysiologie und Pathologie der Galle 1 February 1928Volume 1, Issue 8Page: 558-562KeywordsCholecystectomyGallbladderMigraine ePublished: 1 December 2008 Issue Published: 1 February 1928 PDF downloadLoading ...
Abstract 3589: Warfarin Therapy, Anticoagulation Intensity and Outcomes in Older vs. Younger Patients with Atrial Fibrillation: The ATRIA Study
Authors: Alan S Go, Margaret C Fang, Yuchiao Chang, Leila H Borowsky, Niela K Pomernacki, Daniel E Singer
Journal: Circulation (2007)

Background. Warfarin is highly efficacious for stroke prevention in atrial fibrillation (AF) in selected randomized trial populations. However, controversy exists about its effectiveness and safety and the target INR range in the old and oldest old AF patients in usual clinical care. Methods. We examined anticoagulation-related outcomes associated with older vs. younger age among 13,559 patients with AF within Kaiser Permanente of Northern California between July 1996 and September 2003. Longitudinal warfarin use was characterized using a validated algorithm from filled prescriptions and INR tests found in pharmacy and lab databases. Anticoagulation intensity was characterized using linear interpolation from outpatient INR tests. Risk factors for stroke and bleeding were obtained from clinical and administrative databases. Thromboembolic (TE) and intracranial hemorrhage (ICH) events were identified from hospitalization databases and confirmed by chart review. Results. During 66,754 person-years of follow-up, a large fraction was contributed by older patients: &lt;60 (12.3%), 60 – 69 (18.5%), 70 –79 (37.8%), 80+ (31.4%) years. Older patients were more likely to be women and have a higher prevalence of stroke and bleeding risk factors. Among warfarin users, the proportion of time in therapeutic INR range was similar across age groups (64 – 66%, P=NS). We validated 1041 TE and 279 ICH events. Absolute event rates were higher with older age, but the relative effectiveness of warfarin for preventing TE increased and relative harm due to ICH decreased between ages 60 – 69 and 80+ years (Table ). In separate multivariable analyses, INR 2.0 –3.0 provided the optimal risk-benefit ratio for TE and ICH events across each age category. Conclusion. Among persons with nonvalvular AF, the net clinical benefit of warfarin was greater at older ages. INR 2.0 –3.0 is the optimal target anticoagulation range across the spectrum of age to maximize TE prevention at an acceptable risk of ICH.
Uptake and subcellular distribution of anti-neoplastic agents in wild and drug-resistant human neuroblastoma cells
Authors: Baojun Chang, Sandra H. Clark, Bernard L. Mirkin
Journal: Cancer Research (2006)

Proc Amer Assoc Cancer Res, Volume 47, 2006

617 

The onset of drug-resistance to specific cancer chemotherapeutic agents has been attributed to their increased export and decreased uptake by neoplastic cells. Alterations in nuclear transport and sequestration of anti-neoplastic drugs in subcellular organelles may also play an important role in this adaptive process. An increased expression of p-glycoprotein (P-gp), multi-drug resistance protein (MRP), and other ATP-dependent transport systems has been observed in many drug-resistant cells. This study compared the effect of verapamil on total cellular, nuclear and cytosolic uptake of C14-doxorubicin (C14-DOX), H3-etoposide (H3-ETOP) and C14-5-fluorouracil (C14-5-FU) in wild human neuroblastoma cells (SKNSH-W) and SKNSH cells made resistant to either 10-6M doxorubicin (-rDOX6), 10-5M etoposide (-rETOP5) or 10-4M 5-fluorouracil (-rFU4). Following a 24 hr incubation with verapamil (10-5M) to inhibit P-gp activity, the total cellular, nuclear and cytosolic uptake of C14-DOX was unaltered in SKNSH-W and -rFU4 cells, nor was any change in cytotoxic activity noted. In contrast, C14-DOX uptake by -rDOX6 and -rETOP5 cells were significantly increased by verapamil. These findings were positively correlated with greater cytotoxic effect and a decrease in the IC50 of DOX. Total cellular and cytosolic uptake of H3-ETOP in all drug-resistant cell lines was moderately but significantly increased by verapamil, and cytotoxic potency enhanced in -rDOX6 and -rETOP5 cells only. Nuclear uptake of H3-ETOP in -rDOX6 and -rFU4 cells was not increased by pretreatment with verapamil, but a significant elevation was noted in -rETOP5 cells. The uptake and cytotoxic activity of C14-5-FU in all resistant cell lines was not altered by verapamil. In conclusion, doxorubicin and etoposide, both substrates for P-gp, and 5-fluorouracil, which is not, differed significantly in total cellular, nuclear and cytosolic uptake kinetics and response to P-gp inhibitors. Drug uptake in wild and resistant tumor cells was agent-specific and correlated positively with cytotoxic activity.
Polymerization of the triphosphates of ara-C, 2’,2’-difluorodeoxycytidine and OSI-7836 (4’-thio-ara-C, S-ara-C) by human DNA polymerase α and DNA primase
Authors: Katherine A. Richardson, Tanya P. Vega, Chad L. Moore, John C. Rohloff, Blake Tomkinson, Raymond A. Bendele, Frank C. Richardson, Robert D. Kuchta
Journal: Cancer Research (2004)

Proc Amer Assoc Cancer Res, Volume 45, 2004

2973 

OSI-7836, a nucleoside analog in development for the treatment of solid tumors, may act by affecting DNA synthesis. These studies were undertaken to assess and compare the ability of human polymerase α (pol α) to incorporate ara-CTP, dFdCTP, or the triphosphate of OSI-7836 into DNA using either a synthetic DNA primer or an RNA primer generated by pol α primase. The ability to synthesize over these nucleoside lesions when they are in the DNA was also investigated. Pol α incorporated all three compounds into DNA. In general, these compounds increased the KM ‘s and decreased the VMAX ’s as compared to dCTP. Based on the calculated misinsertion frequencies, pol α would insert 1-OSI-7836TP for every 9-dCTP, 1 ara-CTP for every 24-dCTP and 1-dFdCTP for every 83-dCTP’s. All three triphosphates inhibited α primase synthesis following incorporation of the modified nucleoside, with OSI-7836 being the most potent. OSI-7836TP was a better substrate for α primase than ara-CTP, which in turn was superior to CTP (i.e. OSI-7836 > ara-CTP > CTP). In the coupled reaction in terms of inhibiting elongation, OSI-7836TP was superior to ara-CTP, which was also superior to dFdCTP (i.e.OSI-7836TP >> ara-CTP >> dFdCTP). In addition, ara-CTP and dFdCTP were both incorporated and elongated whereas OSI-7836TP was incorporated but led to chain termination. Pol α synthesized over ara-C, dFdC, or OSI-7836 when the lesion was present in a DNA template, but synthesis was altered in a lesion specific manner. When ara-C was present in the template, there was major pausing of translesion synthesis at the base just before the ara-C lesion. When dFdC was present in the DNA template, there was some pausing of translesion synthesis across from the dFdC lesion. When OSI-7836 was present in the DNA template, there was major pausing of translesion synthesis across from the OSI-7836 lesion. These studies showed that human pol α can polymerize ara-CTP, dFdCTP, and OSI-7836TP into DNA; that, in vitro , OSI-7836TP and ara-CTP are chain terminators, while dFdCTP is not; that OSI-7836-TP cannot be used by pol α primase in a coupled reaction with pol α; and that translesion synthesis is slowed when ara-C, dFdC, or OSI-7836 was present in the template DNA, in a lesion specific manner.
Abstract 955: Molecular Mechanisms of Ca <sup>2+</sup> and Mg <sup>2+</sup> Permeability and pH Sensitivity of the Bi-functional Channel Kinase TRPM7
Authors: Jianyang Du, Mingjiang Li, Jianmin Jiang, William Ratzan, Li-Ting Su, Loren Runnels, Lixia Yue
Journal: Circulation (2007)

The channel-kinase TRPM7 have recently been discovered to play important roles in Mg 2+ and Ca 2+ homeostasis, which is critical to both human health and cell viability. TRPM7 is highly expressed in both cardiac myocytes and fibroblasts. We recently found that both heterologous expressed TRPM7 currents and endogenous TRPM7-like currents in the heart are sensitive to changes of extracellular pH. Acidic pH significantly potentiates inward current of TRPM7. Given the importance of TRPM7 in Ca 2+ and Mg 2+ homeostasis and potential pathological role of TRPM7 under acidosis conditions, this study was designed to elucidate the molecular basis underlying TRPM7’s unique Mg 2+ and Ca 2+ permeability and pH sensitivity. We created a series of amino acid substitutions in the putative pore of TRPM7 to evaluate the origin of the channel’s divalent permeability and pH sensitivity. Two mutants of TRPM7, E1047Q and E1052Q, produced dramatic changes in channel properties. The I–V relations of E1052Q and E1047Q were significantly different from WT TRPM7, with the inward currents of 8- and 12-fold larger than that of TRPM7, respectively. The binding affinity of Ca 2+ and Mg 2+ was decreased by 50-to 140-fold in E1052Q and E1047Q, respectively. Ca 2+ and Mg 2+ currents in E1052Q were 70% smaller than those of TRPM7. Strikingly, E1047Q largely abolished Ca 2+ and Mg 2+ permeation, rendering TRPM7 a monovalent selective channel. In addition, the ability of protons to potentiate inward currents was lost in E 1047Q and largely diminished in E1052Q, indicating that E1047 and E1052Q are critical to TRPM7’s Ca 2+ and Mg 2+ permeability, and its pH sensitivity. Our results indicate that these two glutamate residues are key determinants of both channels’ divalent selectivity and pH sensitivity. These findings reveal the molecular mechanisms underpinning physiological/ pathological functions of TRPM7, and provide molecular insight of the pore architecture of the bi-functional channel kinase TRPM7.