THE PROTHROMBIN RESPONSE TO LARGE DOSES OF SYNTHETIC VITAMIN K IN LIVER DISEASE
Authors: Shepard Shapiro, Richard K. Richards
Journal: Annals of Internal Medicine (1945)

Article1 June 1945THE PROTHROMBIN RESPONSE TO LARGE DOSES OF SYNTHETIC VITAMIN K IN LIVER DISEASESHEPARD SHAPIRO, M.D., RICHARD K. RICHARDS, M.D., F.A.C.P.SHEPARD SHAPIRO, M.D.Search for more papers by this author, RICHARD K. RICHARDS, M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-22-6-841 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe liver is a most versatile organ. Its activities include various types of cellular physiology, principally synthesis, storage, conjugation, catabolism and excretion. Although subject to humoral influence, the functions, nevertheless, appear to be devoid of interdependence. However, despite the "dissociation,"1 certain of the mechanisms exhibit with significant constancy a higher degree of susceptibility to pathologic change than the others. Recently, Drill and Ivy2 found abnormal retention of bromsulphalein to be the earliest detectable alteration in function following the production of liver damage in dogs by the administration of carbon tetrachloride.At the time the paper by Drill and Ivy2appeared...Bibliography1. IVYROTH ACJA: Why do a liver function test? Gastroenterology, 1943, i, 655. Google Scholar2. DRILLIVY VAAC: Comparative values of bromsulphalein, serum phosphatase, prothrombin time, and intravenous galactose test in detecting hepatic damage produced by carbon tetrachloride, Jr. Clin. Invest., 1944, xxiii, 209. CrossrefGoogle Scholar3. QUICK AJ: Hemorrhagic diseases, 1942, Charles C. Thomas, Springfield, Illinois. Google Scholar4. SHAPIROREDISHCAMPBELL SMJHA: Studies on prothrombin 11. The effects of a single small dose of Dicumarol, (3,3′Methylenebis [4-Hydroxycoumarin]) in liver disease, Am. Jr. Med. Sci., 1943, ccv, 808-812. CrossrefGoogle Scholar5. BRINKHAUSWARNER KMET: Effect of vitamin K on hypoprothrombinemia of experimental liver injury, Proc. Soc. Exper. Biol. and Med., 1943, xliv, 609. Google Scholar6. WHITEDEUTSCHMADDOCK FWES: A comparison of blood prothrombin levels with standard function tests in diseases of the liver, New England Jr. Med., 1942, ccxxvi, 327. CrossrefGoogle Scholar7. CAMPBELLSMITHROBERTSLINK HAWKWLKP: Studies on the hemorrhagic sweet clover disease; The bioassay of hemorrhagic concentrates following the prothrombin level in the plasma of rabbit blood, Jr. Biol. Chem., 1941, cxxxviii, 1. Google Scholar8. SHAPIROSHERWINREDISHCAMPBELL SBMJHA: Prothrombin estimation: a procedure and clinical interpretations, Proc. Soc. Exper. Biol. and Med., 1942, l, 85. CrossrefGoogle Scholar9. SHAPIROREDISHCAMPBELL SMJHA: The prothrombinopenic effect of salicylates in man, Proc. Soc. Exper. Biol. and Med., 1943, liii, 251. CrossrefGoogle Scholar10. ANDRUSLORD WDJW (a) : Differentiation of intrahepatic and extrahepatic jaundice, Arch. Int. Med., 1941, lxviii, 199. (b) POHLE, A. J., and STEWART, J. K.: Observations on the plasma prothrombin and the effects of vitamin K in patients with liver or biliary tract disease, Jr. Clin. Invest., 1940, xix, 365. Google Scholar11. ALLENJULIAN JGOC (a) : Clinical use of a synthetic substance resembling vitamin K (2-Methyl-1, 4,-Naphthoquinone), Arch. Surg., 1940, xl, 912. (b) ALLEN, J. G., and JULIAN, O. C.: Response of plasma prothrombin to vitamin K substitute therapy in cases of hepatic disease, Arch. Surg., 1940, xli, 1363. CrossrefGoogle Scholar12. SHAPIROROSSMOORE SVDH: A viscous protein obtained in large amount from the serum of a patient with multiple myeloma, Jr. Clin. Invest., 1943, xxii, 137. CrossrefGoogle Scholar13. BOLLMANBUTTSNELL JLHRAM: The influence of the liver on the utilization of vitamin K, Jr. Am. Med. Assoc., 1940, cxv, 1087. CrossrefGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: North Chicago, Illinois*Received for publication September 16, 1944.This is No. VIII of the series "Studies in Prothrombin."†Hykinone = Menadione - sodium bisulfite prepared by the Abbott Laboratories. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byVitamin KIDIOPATHIC HYPOPROTHROMBINEMIA*JEROME A. COVEY, M.D., JEROME L. COHEN, M.D., JEAN P. PAPPS, M.D.The effect of d-desoxyephedrine upon the prothrombin time 1 June 1945Volume 22, Issue 6Page: 841-851KeywordsCatabolismExcretionLiverLiver diseasesSodiumTetrachlorideVitamin K ePublished: 1 December 2008 Issue Published: 1 June 1945 PDF downloadLoading ...