tbuckley/cabot-search huggingface dataset:
Edge Restenosis After Implantation of High Activity <sup>32</sup> P Radioactive β-Emitting Stents
Authors: Remo Albiero, Takahiro Nishida, Milena Adamian, Antonio Amato, Marco Vaghetti, Nicola Corvaja, Carlo Di Mario, Antonio Colombo
Journal: Circulation (2000)

Background —A high restenosis rate has been reported at the edges (“edge restenosis”) of 32 P radioactive stents with an initial activity level of 3 to 12 μCi. This edge effect might be due to balloon injury and to a low dose of radiation at the stent margins. The aim of this study was to evaluate whether the implantation of 32 P radioactive stents with a higher activity level (12 to 21 μCi) combined with a nonaggressive stent implantation strategy could solve the problem of edge restenosis. Methods and Results —We compared the results of lesions treated with single radioactive BX stents with an activity of 12 to 21 μCi (group 2, n=54 lesions) with the results of lesions treated by single radioactive BX stents with an initial activity level of 3 to 12 μCi (group 1, n=42 lesions). There were no procedural events. At the 6-month follow-up, no myocardial infarctions, deaths, or stent thromboses had occurred. Intrastent binary restenosis was 0% in group 1 versus 4% in group 2 (n=2, both at the ostium of the right coronary artery, P =NS). Intrastent neointimal hyperplasia was significantly lower in group 2 than in group 1. The intralesion (intrastent plus peri-stent) restenosis rate was 38% in group 1 versus 30% in group 2 ( P =NS). Conclusions —Single 32 P radioactive stents with an initial activity level of 12 to 21 μCi reduced intrastent neointimal hyperplasia compared with stents of 3 to 12 μCi, but they did not solve the problem of edge restenosis, even if a nonaggressive stent implantation strategy was used.
Plasma B‐type natriuretic peptide and anti‐inflammatory cytokine interleukin‐10 levels predict adverse clinical outcome in chronic heart failure patients with depressive symptoms: a 1‐year follow‐up study
Authors: John T. Parissis, Dimitrios Farmakis, Maria Nikolaou, Dionysia Birmpa, Vassiliki Bistola, Ioannis Paraskevaidis, Ignatios Ikonomidis, Stavroula Gaitani, Koula Venetsanou, Gerasimos Filippatos, Dimitrios Th. Kremastinos
Journal: European Journal of Heart Failure (2009)
Extracellular DNA traps in bronchoalveolar fluid from a murine eosinophilic pulmonary response
Authors: A. A. Cunha, B. N. Porto, N. K. Nuñez, R. G. Souza, M. H. M. Vargas, J. S. Silveira, T. T. R. Souza, N. Jaeger, P. M. Pitrez
Journal: Allergy (2014)

Asthma is associated with a loss of the structural integrity of airway epithelium and dysfunction of the physical barrier, which protects airways from external harmful factors. Granulocyte activation causes the formation of extracellular traps, releasing web-like structures of DNA and proteins, being important to kill pathogens extracellularly. We investigated whether eosinophils infiltrating airways in an experimental model of asthma would induce eosinophil extracellular traps (EETs) in bronchoalveolar lavage fluid and lung tissue. We showed that an ovalbumin (OVA) asthma protocol presented a significant increase in eosinophil counts with increased extracellular DNA in bronchoalveolar lavage fluid as well as in lung tissue, confirming the presence of DNA traps colocalized with eosinophil peroxidase. EETs formation was reversed by DNase treatment. With these approaches, we demonstrated for the first time that OVA-challenged mice release extracellular DNA traps, which could aggravate pulmonary dysfunction.
Elevated ALCAM Shedding in Colorectal Cancer Correlates with Poor Patient Outcome
Authors: Amanda G. Hansen, Tanner J. Freeman, Shanna A. Arnold, Alina Starchenko, Celestial R. Jones-Paris, Michael A. Gilger, Mary K. Washington, Kang-Hsien Fan, Yu Shyr, Robert D. Beauchamp, Andries Zijlstra
Journal: Cancer Research (2013)

Molecular biomarkers of cancer are needed to assist histologic staging in the selection of treatment, outcome risk stratification, and patient prognosis. This is particularly important for patients with early-stage disease. We show that shedding of the extracellular domain of activated leukocyte cell adhesion molecule (ALCAM) is prognostic for outcome in patients with colorectal cancer (CRC). Previous reports on the prognostic value of ALCAM expression in CRC have been contradictory and inconclusive. This study clarifies the prognostic value of ALCAM by visualizing ectodomain shedding using a dual stain that detects both the extracellular and the intracellular domains in formalin-fixed tissue. Using this novel assay, 105 patients with primary CRCs and 12 normal mucosa samples were evaluated. ALCAM shedding, defined as detection of the intracellular domain in the absence of the corresponding extracellular domain, was significantly elevated in patients with CRC and correlated with reduced survival. Conversely, retention of intact ALCAM was associated with improved survival, thereby confirming that ALCAM shedding is associated with poor patient outcome. Importantly, analysis of patients with stage II CRC showed that disease-specific survival is significantly reduced for patients with elevated ALCAM shedding (P = 0.01; HR, 3.0), suggesting that ALCAM shedding can identify patients with early-stage disease at risk of rapid progression.
Facets of Gynaecology
Authors: W. I. C. Morris
Journal: BMJ (1966)

Complete penile amputation is a rare and poorly documented injury with severe physical and psychosocial implications. Our institution presents a case of successful penile replantation following 23 hours of ischaemia time in a 34-year-old man with a history of paranoid schizophrenia who sustained a complete penile amputation during an act of deliberate self-harm. To the best of our knowledge, this is the longest documented ischaemia time for a successful penile replant in literature. The patient was able to achieve a full erection as early as 6 weeks postoperatively. Skin necrosis was noted as a common complication and this was successfully managed with debridement and skin grafting. Penile amputation injuries should be managed in a specialist centre with urological and plastic surgeons with expertise in microsurgical reconstruction. Penile replantation should be attempted, even if ischaemia time is prolonged, despite lower success rates given the significance of the injury to an individual.
Plasma Fibrinogen in NIDDM: The Rotterdam Study
Authors: Rossen M Missov, Ronald P Stolk, Johanna G van der Bom, Albert Hofman, Michiel L Bots, Huibert A P Pols, Diederick E Grobbee
Journal: Diabetes Care (1996)

OBJECTIVE To compare plasma fibrinogen levels across groups of subjects with and without NIDDM with respect to diabetes therapy and to evaluate the influence of metabolic control and other selected factors. RESEARCH DESIGN AND METHODS In a cross-sectional study, plasma fibrinogen was measured in 2,971 elderly subjects aged 55 years and older (mean age 70.8 years). This was part of the baseline examination of the Rotterdam Study, a population-based study of chronic diseases in the elderly. RESULTS Plasma fibrinogen levels did not differ among subjects with and without NIDDM (2.84 vs. 2.81 g/l, P = 0.5). After adjustment for age, sex, smoking, BMI, and waist-to-hip ratio, the plasma fibrinogen levels were higher in subjects receiving insulin therapy. In those without diabetes (n = 2,640), with diabetes but not taking antidiabetes medication (n = 196), taking oral medication (n = 99), and taking insulin (n = 36), the age- and sex-adjusted fibrinogen levels were 2.82 (SE 0.01), 2.79 (0.05), 2.79 (0.07), and 3.23 (0.11) g/l, respectively (P &amp;lt; 0.005). Adjustment for leukocyte count or serum creatinine level did not affect the observed association, while adjustment for fructosamine decreased the differences. CONCLUSIONS Plasma fibrinogen levels are elevated in insulin-treated NIDDM patients, which may reflect worse metabolic control in this subgroup.
Abstract 1686: Identification of potential prostate cancer biomarkers associated with TMPRSS2-ERG fusion and PTEN deletions
Authors: Amal A. Almami
Journal: Cancer Research (2012)

Abstract Background: ERG gene rearrangements and PTEN genomic deletions have been shown to be associated with specific molecular subtype of prostate cancer (PCA). It has been also suggested that tumors showing those two genetic aberrations are associated with worse prognosis compared to tumors with none of those genetic aberrations. In this study, we investigated gene expression differences between those two classes of tumors to identify potential genetic targets and pathways Material and Methods: 6144 informative genes belonging to 59 HRPCA samples were previously studied using the DASL platform. We used Singular Value Decomposition (SVD), as an effective method for analyzing gene expression data based on their ERG and PTEN status. We used the normal prostate cell line RWPE-1 as well as different prostate cancer cell lines (LNCaP, VCaP, DU145 and PC-3) to validate the results of microarray expression profiling. We screened for the expression of the different proteins by means of real time PCR and western blot studies. Results: MMP1 and LEF1 protein expression was much higher in VCaP cells and almost absent in RWPE-1 cells while MEIS2, CHD5 and Syntenin were expressed differently between cell lines and were not specifically in VCaP which is only cell line that harbor the ERG fusion. Conclusion: In this preliminary study we show that MPP1 and LEF-1 might be associated with the TMPRSS2-ERG fusion since their expression was much higher in VCaP cell line compared to other cell lines. However, further studies are still needed to confirm these results in TMPRSS2-ERG knockdown VCaP cells. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 103rd Annual Meeting of the American Association for Cancer Research; 2012 Mar 31-Apr 4; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2012;72(8 Suppl):Abstract nr 1686. doi:1538-7445.AM2012-1686
Intraperitoneal Haemorrhage from Fibroids
Authors: P. K. Choudhuri
Journal: BMJ (1961)

JOURNAL 12 st.12 lb.(81.6 kg.) for years.Incidentally, I have played games beyond the normal ages: rugger up to 46, hockey to 63, and cricket to present age.My four children (two boys, two girls; boys seem to lag more than girls) have been the same.In some ways this was a great handicap at and beyond the end of school life when trying to compete for scholarships, etc.None of us got scholarships, but all finally got firsts or seconds in university finals.I have observed the same in children of three other long-lived families in which the parents or/and grandparents lived well into the eighties and nineties.I suggest that this might be a subject for research and comment in an editorial.
Hypertrichosis lanuginosa acquisita associated with pancreatic carcinoma
Authors: DAVID I. MCLEAN, JOHN C. MACAULAY
Journal: British Journal of Dermatology (1977)

A patient with hypertrichosis lanuginosa acquisita associated with pancreatic islet cell carcinoma, probably D cell type, is presented. The hypertrichosis antedated other evidence of malignancy.
Experts Debate Randon's Cancer Risks
Authors: T. Reynolds
Journal: JNCI Journal of the National Cancer Institute (1991)

Journal Article Experts Debate Randon's Cancer Risks Get access Tom Reynolds Tom Reynolds Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 83, Issue 12, 19 June 1991, Pages 810–812, https://doi.org/10.1093/jnci/83.12.810 Published: 19 June 1991
Passage of health bill into law is unlikely to help GPs "heaving under the pressure" of NHS changes
Authors: Z. Kmietowicz
Journal: BMJ (2012)

The passage of the Health and Social Care Bill into the statute books, which many believe will happen on 20 March, is unlikely to bring any relief from the chaos or confusion caused since it was published 18 months ago and won’t reduce pressure on GPs in England, say experts who have scrutinised the legislation.

Clare Gerada, chairwoman of the Royal College of General Practitioners, told the BMJ that the next few months will be spent “having to unpick what this complicated and conflicting legislation actually means.”

GPs have been “heaving under the pressure” to provide effective clinical care while many of their colleagues have been taken away from frontline care to set up clinical commissioning groups (CCGs) and develop new services, she said.

“There is still a lot of work that needs to be done regarding secondary legislation and the implementation of the bill, authorisation of CCGs, and giving expert advice to the national commissioning board,” she told the BMJ . “The only way forward is to release resources to help GPs spend more …
THE FIRST PERMANENT MOLAR
Authors: FREDERICK B. NOYES
Journal: JAMA (1922)

In 1887, Dr. Andrieu of Paris read a paper before the section on dental and oral surgery of the Ninth International Medical Congress, advocating the extraction of the first permanent molars. His argument was based on the fact that 75 per cent, of these teeth decay. Black and others who have collected statistics on this subject have agreed that caries occurs in these teeth in a much larger percentage than in any other tooth in the denture, and that more of them are lost from decay than any other tooth. Since the reading of Andrieu's paper, there have been constantly appearing articles advocating the wholesale removal of these teeth. In recent years, and even at the present time, this procedure has often been advocated for avoiding, or correcting, crowding and irregularity of the teeth. The purpose of this paper is to point out the fundamental fallacy in this procedure. It
PMO-179 Role of antivirals in acute hepatitis B infection; a 5-year experience at a liver transplant centre
Authors: V S Hegade, N Mohammed, M Aldersley, S Riyaz
Journal: Gut (2012)

<h3>Introduction</h3> Acute hepatitis B in adults is successfully cleared in more than 95% of immunocompetent patients. A small proportion of patients develop fulminant hepatitis. Few controlled trials<sup>1 2</sup> have evaluated the role of antivirals in patients with acute severe hepatitis B (AS-HBV). The aim of this study was to report our experience of AS-HBV management at a tertiary centre. <h3>Methods</h3> We retrospectively identified all patients between August 2006 and August 2011, referred to our centre with acute HBV infection (diagnosis based on recent onset of jaundice, detection of serum HBsAg and IgM HBcAb). 1-Year data following the diagnosis was collected using medical and electronic records. We identified all patients meeting at least one of the three criteria for AS-HBV<sup>1</sup> that is, INR ≥1.6, serum bilirubin ≥170 μmol/l and hepatic encephalopathy. Patients with other causes of acute liver injury such as alcohol and drugs were excluded. <h3>Results</h3> 98 patients with acute HBV were identified during the study period. Of these, 64 (65.3%) patients had milder episodes. Thirty-four patients (34.7%; mean age 32, 50% females) had evidence of AS-HBV. Out of these, 17 (50%) patients had a bilirubin ≥170 μmol/l and 3 (8.8%) patients had INR ≥1.6 while 14 (41%) patients had both. None of the AS-HBV patients had evidence of encephlopathy. All patients had normal ultrasound scans of the liver and negative non-invasive liver screen, at the time of diagnosis. Of the 34 patients with AS-HBV, 20 (59%) patients received treatment with antiviral drugs, 55% with newer agents (Entecavir or Tenofovir) and 45% with older agents (Lamivudine or Adefovir). None of the patients developed any side effects to antiviral drugs. The remaining 14 (41%) patients with AS- HBV received supportive care only. There were no deaths or need for liver transplantation in either group. <h3>Conclusion</h3> Acute hepatitis B usually runs a benign course but a proportion of patients can develop severe disease. Patients with acute severe hepatitis B may be safely treated with anti-viral drugs. Randomised controlled studies with newer antiviral agents are required to establish guidelines in treating patients with acute severe hepatitis B. <h3>Competing interests</h3> None declared. <h3>References</h3> 1. <b>Schmilovitz-Weiss H</b>, <i>et al.</i> Lamivudine treatment for acute severe hepatitis B: a pilot study. <i>Liver Int</i> 2004;<b>24</b>:547–51. 2. <b>Kumar M</b>, <i>et al.</i> A randomized controlled trial of lamivudine to treat acute hepatitis B. <i>Hepatology</i> 2007;<b>45</b>:97–101.
Roles for MicroRNAs, miR-93 and miR-130b, and Tumor Protein 53–Induced Nuclear Protein 1 Tumor Suppressor in Cell Growth Dysregulation by Human T-Cell Lymphotrophic Virus 1
Authors: Man Lung Yeung, Jun-ichirou Yasunaga, Yamina Bennasser, Nelson Dusetti, David Harris, Nafees Ahmad, Masao Matsuoka, Kuan-Teh Jeang
Journal: Cancer Research (2008)

Abstract A role for microRNAs (miRNA) in human T-cell leukemia virus 1 (HTLV-1)–mediated cellular transformation has not been described. Here, we profiled miRNA expression in HTLV-1–transformed human T-cell lines and primary peripheral blood mononuclear cells from adult T-cell leukemia patients. Analyses of 11 different profiles revealed six miRNAs that were consistently up-regulated. Two of the up-regulated miRNAs (miR-93 and miR-130b) target the 3′ untranslated region (3′UTR) of the mRNA for a tumor suppressor protein, tumor protein 53–induced nuclear protein 1 (TP53INP1). A low expression level of TP53INP1 protein was found in HTLV-1–transformed cells. Additionally, when antagomirs were used to knock down miR-93 and miR-130b in these cells, the expression of TP53INP1 was increased, suggesting that the latter is regulated inside cells by the former. A role for TP53INP1 in regulating cell growth was established by experiments that showed that enhanced TP53INP1 expression increased apoptosis. Collectively, the findings implicate a miR-93/miR-130b-TP53INP1 axis that affects the proliferation and survival of HTLV-1–infected/transformed cells. [Cancer Res 2008;68(21):8976–85]
THE SPECIFICITY OF SEROLOGICAL PRECIPITATION
Authors: Frank Lanni
Journal: The Journal of Experimental Medicine (1946)

Precipitative mixing experiments have been conducted with the aid of a turbidimeter and a darkfield microscope. The results of these experiments, correlated with observations of macroscopic features, indicate that serological precipitation is largely governed by a highly specific mechanism except in the terminal period, when the operation of non-specific forces becomes apparent. The findings are used as the basis for a new description of precipitation in terms of the formation and aggregation of elementary particles of specific precipitate, called seromicrons.
MULTIPLE CASES OF TONSILLECTOMY AND POLIOMYELITIS
Authors: Carl E. Krill
Journal: JAMA (1941)

The presence of poliomyelitis in epidemic form in various parts of the United States during this summer and fall, the obvious increase in the incidence of the bulbar type of the disease and the suspected association between tonsillectomies and bulbar types of paralysis make the present preliminary report of general interest. Five of six children, aged 11, 9, 8, 7 and 6 years, had a tonsillectomy and adenoidectomy on August 22. The operations were done under general anesthesia and under the strictest of aseptic precautions in a clinic, and the children went home the same day in good condition. Three of the children began to show symptoms of poliomyelitis on September 3. One child probably started to have symptoms on the 3d and another on the 5th of September. All the symptoms were referred to the gastrointestinal tract—anorexia, nausea and vomiting. Dysarthria and dysphagia developed in 3 of the children
RECURRENT DISLOCATION OF THE SHOULDER JOINT
Authors: T. TURNER THOMAS
Journal: JAMA (1925)

Recurrent dislocation of the shoulder joint has excited considerable discussion in this country in recent years, and in consequence there is much less tendency to discuss different causes and the different operations based on these causes. It may fairly be said that the nonoperative treatment, by braces, offers practically no relief, and that the operative treatment is confined almost entirely to methods of contracting the axillary portion of the capsule. The employment of a portion of the deltoid muscle as a flap passed under the humeral head as a sling support to prevent its escape from the socket has earned the right to be considered among the available methods of treatment. As much can hardly be said for dividing the muscles in the axillary folds to overcome their supposed effect in pulling the humeral head from its socket or glenoid cavity. The advocate of any particular view as to the
Ethics of Renal Biopsy
Authors: KENNETH M. FLOYD
Journal: Annals of Internal Medicine (1974)

Comments1 January 1974Ethics of Renal BiopsyKENNETH M. FLOYD, M.D., F.A.C.P.KENNETH M. FLOYD, M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-80-1-117 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: After reading the article by Dr. Sagel and colleagues (Ann Intern Med79:492-499, 1973), on glomerular lesions after group A streptococcal infections in children, I had to ask myself how far we as clinicians are permitted to go in the quest of scientific knowledge. Although one cannot question the intellectual integrity of the authors in seeking additional information about a disease entity, one can morally question exposing 20 asymptomatic children to the risks of percutaneous renal biopsy for no other reason than intellectual curiosity. How many of us reading this letter would be willing to have...References1. TRESEREHRENREICHORES GTR: Natural history of "apparently healed" acute poststreptococcal glomerulonephritis. Pediatrics 43:1005-1017, 1969 MedlineGoogle Scholar2. BALDWIN D: Natural history of poststreptococcal glomerulonephritis. Proceedings of the Fifth International Congress of Nephrology, Mexico City, Mexico, 1972 Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByThe outcome of percutaneous renal biopsy in children: an analysis of 120 consecutive casesRenal BiopsyInfectious diseases: fortieth and final annual review of significant publications. 1 January 1974Volume 80, Issue 1Page: 117-118KeywordsBiopsyChildrenLesionsRenal diseasesStreptococcal infections Issue Published: 1 January 1974 PDF DownloadLoading ...
Differential Diagnosis of Acute Meningitis
Authors: Alan Spanos
Journal: JAMA (1989)

We analyzed data from the records of 422 patients with acute bacterial or viral meningitis. A cerebrospinal fluid (CSF) glucose level less than 1.9 mmol/L, a CSF-blood glucose ratio less than 0.23, a CSF protein level greater than 2.2 g/L, more than 2000 x 10(6)/L CSF leukocytes, or more than 1180 x 10(6)/L CSF polymorphonuclear leukocytes were individual predictors of bacterial infection with 99% certainty or better. Although any one of these tests could rule in bacterial meningitis with high probability, none could rule it out. To better predict whether a patient has bacterial vs viral infection, we developed a logistic multiple regression model using CSF-blood glucose ratio, total polymorphonuclear leukocyte count in CSF, age, and month of onset. This proved highly reliable when validated in an independent test sample, with an area under receiver operating characteristic curve of 0.97. The model should allow physicians to differentiate between acute viral and acute bacterial meningitis with greater accuracy.