tbuckley/cabot-search huggingface dataset:
Radiation Therapy and Risk of Cardiovascular Disease—Reply
Authors: Nancy Price Mendenhall
Journal: JAMA (2004)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Molecular basis of altered red blood cell membrane properties in Southeast Asian ovalocytosis: role of the mutant band 3 protein in band 3 oligomerization and retention by the membrane skeleton
Authors: SC Liu, J Palek, SJ Yi, PE Nichols, LH Derick, SS Chiou, D Amato, JD Corbett, MR Cho, DE Golan
Journal: Blood (1995)
Adaptive immune responses in <i>Staphylococcus aureus</i> biofilm–associated chronic rhinosinusitis
Authors: A. Foreman, G. Holtappels, A. J. Psaltis, J. Jervis‐Bardy, J. Field, P. ‐J. Wormald, C. Bachert
Journal: Allergy (2011)

To cite this article: Foreman A., Holtappels G., Psaltis A.J., Jervis‐Bardy J., Field J., Wormald P.‐J., Bachert C. Adaptive immune responses in Staphylococcus aureus biofilm–associated chronic rhinosinusitis. Allergy 2011; 66 : 1449–1456. Abstract Background: The etiopathogenesis of chronic rhinosinusitis (CRS) is currently an area of intense debate. Recently, biofilms have been proposed as a potential environmental trigger in this disease. In particular, Staphylococcus aureus biofilms appear to be a predictor of severe disease recalcitrant to current treatment paradigms. However, direct causal links between biofilms and host immune activation are currently lacking. This study aimed to document both the adaptive immune responses that characterize S. aureus biofilm–associated CRS and the relative contributions of staphylococcal superantigens and S. aureus biofilms in the inflammatory make‐up of this disease. Methods: A total of 53 disease subjects and 15 controls were recruited. Sinonasal mucosa was collected for the determination of S. aureus and Haemophilus influenzae biofilms and presence of total and superantigen‐specific IgE and for the measurement of cytokines that characterize the T‐helper pathways. Results: Staphylococcus aureus biofilms and superantigens are significantly associated in CRS patients, suggesting the biofilm may be a nidus for superantigen‐eluting bacteria. The presence of S. aureus biofilms is associated with eosinophilic inflammation, across the spectrum of CRS, on the back of a T‐helper 2 skewing of the host’s adaptive immune response (elevated Eosinophilic Cationic Protein and IL‐5). This can be distinguished from the superantigenic effect resulting in the induction of IgE. Conclusion: This study provides novel evidence of a link between S. aureus biofilms and skewing of the T‐cell response toward the T‐helper 2 pathway that is independent of superantigen activities. Further research is required to confirm the cause–effect relationship of this association.
Abstract 14671: Myocardial Recovery After Initial Hospitalization for Heart Failure in Patients with Non-ischemic Cardiomyopathy
Authors: Jane E Wilcox, Adi C Andrei, Siddhartha Jonnalagadda, Donald M Lloyd-Jones
Journal: Circulation (2014)

Background: Recovery of myocardial function has been demonstrated in outpatients with heart failure (HF) due to non-ischemic cardiomyopathy (NICM), but little is known about the high-risk population of patients after hospitalization for HF (HHF). We sought to examine the proportion of patients with NICM who experience myocardial recovery after initial HHF and examine outcomes associated with recovery status. Methods: We identified patients with first HHF from NICM [reduced left ventricular ejection fraction (LVEF) ≤ 40%, not due to CAD, valvular disease, chemotherapy, infiltrative disease] using the Northwestern Medicine Enterprise Data Warehouse from January 1, 2000 to January 1, 2013. Myocardial recovery status was defined as: 1) myocardial recovery (absolute LVEF improvement ≥10%), 2) no change/ worsening of LVEF, and 3) no subsequent LVEF assessment. Multivariable-adjusted regression models were fitted to test the association between myocardial recovery status and all-cause mortality. Results: There w...
205. Histopathlogical and Physiological Impact on Monkey Intracranial Aneurysms Transfecting Transforming Growth Factor-Beta-1 Mediated by Adenovirus
Authors: Shigeki Ono, Tomoyuki Ogawa, Tomohito Hishikawa, Tomotsugu Ichikawa, Isao Date
Journal: Molecular Therapy (2004)

Introduction: Regarding intracranial aneurysms, unruptured aneurysms threat human life because they have potential to rupture and result in subarachnoid hemorrhage, which is one of the most serious brain attacks. In order to inhibit aneurysmal rupture experimentally, we investigate whether gene transfer of transforming growth factor-beta-1 (TGFbeta-1) to the intracranial aneurysms is effective method for occlusion of the aneurysmal lumen or not, using the monkey model. Materials and Methods:
Inability of p-Hydroxypropiophenone to Inhibit the Appearance of Spontaneous Hepatomas in the C3H Mouse
Authors: Tsuneo Baba
Journal: JNCI Journal of the National Cancer Institute (1960)

Journal Article Inability of p-Hydroxypropiophenone to Inhibit the Appearance of Spontaneous Hepatomas in the C3H Mouse Get access Tsuneo Baba Tsuneo Baba Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 24, Issue 3, March 1960, Pages 685–690, https://doi.org/10.1093/jnci/24.3.685 Published: 01 March 1960 Article history Received: 30 July 1959 Published: 01 March 1960
Abstract 16304: Aortic Valve Calcification on Cardiac Computed Tomography and All Cause Mortality
Authors: Michael J Blaha, Matthew J Budoff, Juan J Rivera, Raul D Santos, Atif N Khan, Leslee J Shaw, James K Min, Dan Berman, Paolo Raggi, John A Rumberger, Roger S Blumenthal, Khurram Nasir
Journal: Circulation (2010)
412. Cyclosporine Inhibits the Induction of GFP Specific Immune Responses after Transplantation of Lentivirally Transduced GFP Expressing Hematopoietic Stem Cells in Dogs
Authors: Karen Beagles, Laura Peterson, Tobias Neff, Hans-Peter Kiem
Journal: Molecular Therapy (2004)

Green fluorescent proteins have been widely used to monitor gene transfer and expression following lentiviral and oncoretroviral transduction of baboon and canine repopulating hematopoietic cells. Recent studies in our laboratory have shown a complete disappearance of GFP-containing cells following transplantation of lentivirally transduced repopulating cells in several baboons. The complete disappearance of genetically modified cells was shown to be mediated by a transgene specific immune response. We have also observed a complete disappearance of GFP marked cells following transplantation of lentivirally transduced hematopoietic cells in dogs. To identify a possible role the immune system may have in the disappearance of these cells, eight dogs were preconditioned with ablative irradiation and were transplanted with a lentiviral vector containing the GFP transgene. Blood samples were obtained twice a week for up to 800 days and the GFP transgene product was measured by flow cytometry in blood leukocytes. Six dogs showed stable GFP marking in blood leukocytes over 800 days demonstrating engraftment of transgene expressing cells. However, two dogs began to lose marking between 30 and 50 days post-transplant. To determine whether an immune response to GFP was responsible for the disappearance of gene modified cells in dogs that exhibited a decrease in GFP marking, peripheral blood leukocytes were isolated by a Ficoll gradient and stimulated in vitro for 5 days using GFP peptides. Immune responses were detected by measuring intracellular levels of TNFa using flow cytometry. Dogs that exhibited a decrease in GFP marking developed potent immune responses in vitro to the transgene product GFP as shown by an increase in GFP specific TNFa production (p<0.05) when compared to non-transplanted controls. To determine whether cyclosporine could prevent disappearance of GFP marked cells, six dogs were treated with cyclosporine following transplantation of lentivirally transduced hematopoietic cells. Dogs treated with cyclosporine post- transplant showed stable GFP marking in blood leukocytes over 800 days. However, two dogs that were not treated with cyclosporine exhibited a complete loss of GFP marking in blood leukocytes. Furthermore, potent immune responses were detected in dogs that had not received post-transplant cyclosporine treatment (n = 2; p<0.05). Our data suggest that cyclosporine prevents immunoactivation against transgene products following bone marrow transplantation using lentivirally modified cells as indicated by stable GFP marking. These findings should have important implications for the development of stem cell gene therapy protocols for patients with generic diseases.
Abstract 10053: Progression of Coronary Calcium and Incident Coronary Heart Disease Events: The Multi-Ethnic Study of Atherosclerosis (MESA)
Authors: Matthew J Budoff, Victor A Lopez, Khurram Nasir, Roger S Blumenthal, Robert C Detrano, Richard Kronmal, Diane Bild, Alan Guerci, Kiang Liu, Steven Shea, Moyses Szlko, Wendy Post, Joao A Lima, Alain Bertoni, Nathan D Wong
Journal: Circulation (2011)

Background: Coronary artery calcium (CAC) is a strong predictor of future coronary heart disease (CHD) events in asymptomatic adults; however, the incremental prognostic importance of CAC progressi...
GM-CSF enhances 3F8 monoclonal antibody-dependent cellular cytotoxicity against human melanoma and neuroblastoma
Authors: BH Kushner, NK Cheung
Journal: Blood (1989)

Abstract 3F8 is a murine monoclonal IgG3 antibody specific for the tumor- associated antigen ganglioside GD2. Previous in vitro studies suggest that tumor regressions observed in a phase I clinical trial of 3F8 may be attributable to complement activation by 3F8 and to 3F8-dependent cellular cytotoxicity (ADCC) with lymphocytes. We now describe 3F8- mediated ADCC of GD2-positive tumor targets (melanoma and neuroblastoma) with human granulocytes and report that recombinant human granulocyte-macrophage colony-stimulating factor (GM-CSF) enhanced this phenomenon. Cytotoxicity required binding of 3F8 to the low-affinity Fc receptor type III (CD16) on the granulocytes and was poor with tumor-binding monoclonal antibodies of other immunoglobulin (ie, non-IgG3) subclasses. GM-CSF (2 to 20 ng/mL) increased ADCC by 93% to 267% at limiting dilutions of 3F8 (1 microgram/mL). With most GD2- positive cell lines tested, this effect translated into a tenfold or greater augmentation in 3F8 efficiency at mediating ADCC. Comparable enhancement occurred whether GM-CSF was present in the ADCC assay or granulocytes were incubated with GM-CSF and washed before the assay. Nonoxidative mechanisms may be important for ADCC since 3F8 mediated ADCC with granulocytes from two children with chronic granulomatous disease; this cytotoxicity was also enhanced by GM-CSF. Since GM-CSF induces a neutrophilia in patients, our data suggest that this cytokine may have the potential of amplifying 3F8 antitumor activity in patients by increasing effector cell numbers and by priming granulocytes for greater cytotoxicity.
Ownership and Use of Tissue Specimens for Research
Authors: William J Catalona
Journal: JAMA (2005)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Cytophotometric Data on Fluorochromed Cervical Cells&lt;xref ref-type="fn" rid="FN1"&gt;2&lt;/xref&gt;
Authors: Marianna Masin, Francis Masin
Journal: JNCI Journal of the National Cancer Institute (1961)

A simplified fluorophotometric device for measuring the light emission of the whole-cell area of single isolated cells is described. Ehrlich ascites carcinoma cells stained with the basic fluorochrome acridine orange were used for a model experiment. The sensitivity of the used photomultiplier 1P21 for the green-yellow emitted by the nuclear area was about 4 times greater than that for the metachromatic red of the cytoplasmic and nucleolar ribonucleic acid. Galvanometer readings over concentric cell areas of varying diameters showed that nuclear emission was mainly responsible for the total recorded fluorescence intensity. Photometric data obtained on single fluorochromed cervical cells gave mean emission values approximately 2 times higher for abnormal than for corresponding normal cells. Emission values of abnormal cells were distinctly above the level of a dividing line at 36.2 emission units and were well separated from normal cells. The differential staining of nucleus and cytoplasm by a basic fluorochrome with well-delineated nucleo-cytoplasmic boundaries is of advantage for detection of cellular atypia by visual observation. In addition, cytophotometric data can yield valuable evidence in closer identification and separation of degrees of cellular abnormalities, especially where cytologic classification and tissue findings are not conclusive.
A concept of diffuse actinic arteritis.
Authors: JOHN P. O'BRIEN
Journal: British Journal of Dermatology (1978)

Actinic damage (actinic elastosis) affecting the internal elastic lamina appears to be the prime cause of 'age change' and arteritis of the temporal artery. Resorption and removal of altered elastin (elastolysis) is an integral part of the pathology of actinic damage. Actinic irradiation is probably responsible for the destruction and disappearance of a vast number of arterioles in elastotic skin. The intimate connection between temporal arteritis and polymyalgia rheumatica prompts the belief that the vascular and other internal malign components of the temporal arteritis/polymyalgia rheumatica syndrome might likewise be due, albeit indirectly, to the same actinic cause. Actinic elastotic damage at the body surface could have this effect by provoking a state of systemic elastolysis. Although ultraviolet (uv) light is often regarded as the sole cause of actinic elastosis, penetrating infrared (heat) irradiation may deserve a large or even a dominant share of the blame.
Late-breaking abstract: The bromodomain-containing protein 4: The epigenetic origin of the oncogenic signature in pulmonary hypertension
Authors: Mylene Vaillancourt, Jolyane Meloche, Pasquale Ferraro, Steeve Provencher, Sebastien Bonnet
Journal: European Respiratory Journal (2014)

Background: As in cancer, pulmonary arterial hypertension (PAH) is associated with sustained DNA damage accounting for a PARP-1-dependent downregulation of miR-204. By an unknown mechanism, miR-204 promotes the expression of several oncogenes implicated in PAH including Survivin, Bcl-2, Pim-1 and c-Myc. Once activated, by affecting the mitochondrial function through the transcription factor NFAT, they contribute to the pro-proliferative and anti-apoptotic phenotype of PAH-pulmonary arterial smooth muscle cells (PASMC). In cancer, studies demonstrated that the epigenetic reader Bromodomain-containing protein 4 (BRD4) increases transcription of multiple oncogenes sustaining cell proliferation. Interestingly, BRD4 is upregulated by DNA damage and is a predicted target of miR-204. We hypothesized that the PARP-1/miR-204-dependent upregulation of BRD4 triggers the oncogenes-dependent pro-proliferative and anti-apoptotic phenotype seen in PAH-PASMC.

Method/Results: BRD4 is upregulated in lungs, distal PAs and PASMC of PAH patients compared to healthy donors. This increase is miR-204 dependent, as miR-204 upregulation in PAH-PASMC decreases BRD4. BRD4 activation induces Bcl2, Survivin, c-Myc and Pim1 expression, leading to mitochondrial hyperpolarization (TMRM) and NFAT activation in PAH-PASMC, all of which were reversed upon molecular (siRNA) and pharmacological (JQ1 and I-BET) BRD4 inhibition. Finally, BRD4 inhibition reverses PAH-PASMC proliferation (Ki67) and resistance to apoptosis (TUNEL).

Conclusion: Our study suggests an important role for BRD4 in pulmonary hypertension and opens the door to new avenues of investigation and proposes BRD4 as putative treatment for PAH.
Vegetative pyoderma gangrenosum in chronic renal failure
Authors: M. Goto, O. Okamoto, S. Fujiwara, T. Yanagi, S. Komada, S. Yokoyama, S. Takayasu
Journal: British Journal of Dermatology (2002)

We report the case of a 58‐year‐old woman with painful recurrent erythematous lesions on both legs of 6 months' duration. The patient had been treated with haemodialysis for chronic renal failure for the previous 10 years. Physical examination revealed pea‐sized erythematous nodules with sinus formation and discharge of bloody pus, which yielded neither bacterial nor fungal cells in culture. These lesions healed leaving cribriform scars, after bed rest, topical disinfection and systemic and in some areas intralesional corticosteroids. Cases of pyoderma gangrenosum are usually classified as one of four clinical variants: ulcerative, pustular, bullous and vegetative. Our case might correspond to a vegetative form in view of the development of sinuses, neutrophilic abscesses and palisading granuloma, even though no ulceration was observed.
Book: Infectious Causes of Cancer: Targets of Intervention
Authors: D Trichopoulos
Journal: BMJ (2001)

Ed James J Goedert Humana Press, £87.05, pp 498 ISBN 0 89603 772 X

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The title of this book is subtly and unintentionally misleading. Its focus is on cancer of infectious origin rather than on the infectious causes of cancer. The book deals with mechanistic, largely molecular, pathogenetic processes with a view to therapeutic intervention rather than issues of causality with a view to prevention strategies. Nevertheless, the …

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Biological and therapeutic potential of membrane lipid modification in tumors.
Authors: Spector Aa, Burns Cp
Journal: Cancer Research (1987)

The membrane fatty acid composition of cancer cells can be modified either in culture or during growth in animals without disrupting basic membrane or cellular integrity. Only fatty acids are affected; no changes occur in membrane cholesterol, phospholipid, or protein content. There are changes in membrane physical properties and certain cellular functions, including carrier-mediated transport, receptor binding, ion channels, and eicosanoid production. Fatty acid modification also can enhance the sensitivity of the cells to hyperthermia and Adriamycin. This technique provides a new approach to understanding the membrane properties of neoplastic cells. Membrane fatty acid modification also may be of potential value as a therapeutic approach designed to augment the cytotoxicity of other antineoplastic therapies.
The book of health; a medical encyclopedia for everyone.
Authors: Randolph Lee Clark, Russell Walters Cumley
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Magazine: Magazine's HIV claim rekindles "gay plague" row
Authors: K. Howard
Journal: BMJ (2003)

The US glossy magazine Rolling Stone is best known for its coverage of the latest music and movies. But recently it tried its hand at a little HIV epidemiology, and found itself accused of sensationalism and virulent homophobia.

In a feature called “In search of death,” published in its February issue, the magazine suggested that a new craze is sweeping America. Thousands of gay men each year are apparently seeking out HIV positive partners in order to become infected. These men are known as “bug chasers.” The men who give them the virus are “gift givers.”

This was not the first story about bug chasing—in September 1997, for example, Newsweek ran a feature entitled “A deadly dance” that discussed the phenomenon. What was shocking about the Rolling Stone article was its assertion that an astonishing 25% of all new HIV infections in gay men was caused by bug chasing.

The article profiled one bug chaser called Carlos (a pseudonym), a 32 year old gay man living in New York, who has an intense desire to become infected …
Aortic Stenosis in the Elderly
Authors: Ruben L.J. Osnabrugge, Darren Mylotte, Stuart J. Head, Nicolas M. Van Mieghem, Vuyisile T. Nkomo, Corinne M. LeReun, Ad J.J.C. Bogers, Nicolo Piazza, A. Pieter Kappetein
Journal: Journal of the American College of Cardiology (2013)
Mutations in the gene encoding fibroblast growth factor 10 are associated with
Authors: Miriam Entesarian, Hans Matsson, Joakim Klar, Birgitta Bergendal, Lena Olson, Rieko Arakaki, Yoshio Hayashi, Hideyo Ohuchi, Babak Falahat, Anne Isine Bolstad, Roland Jonsson, Marie Wahren-Herlenius, Niklas Dahl
Journal: Nature Genetics (2005)