EXPERIMENTAL LAENNEC TYPE OF CIRRHOSIS IN MONKEYS
Authors: George F. Wilgram
Journal: Annals of Internal Medicine (1959)

Article1 December 1959EXPERIMENTAL LAENNEC TYPE OF CIRRHOSIS IN MONKEYSGEORGE F. WILGRAMGEORGE F. WILGRAMSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-51-6-1134 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptDespite extensive research, no proved concept of the etiology of Laennec's cirrhosis has yet been established. Cirrhosis has been produced experimentally by different means in several species (mice, rats, guinea pigs, rabbits, dogs).1-21However, some pathologists have contended that the resulting lesions lack certain criteria that permit the diagnosis of Laennec's cirrhosis and would not allow any application to man. It was therefore felt that an experimental reproduction of Laennec's cirrhosis in primates might shed some light on this complex problem in man. Little work has been done so far on primates. After numerous failures using various abnormal diets on...Bibliography1. EdwardsDalton JEAJ: Induction of cirrhosis of the liver and of hepatomas in mice with carbon-tetrachloride, J. Nat. Cancer Inst. 3: 19, 1942. Google Scholar2. GyoergyGoldblatt PH: Experimental production of dietary liver injury (necrosis, cirrhosis) in rats, Proc. Soc. Exper. Biol. and Med. 46: 492, 1941. CrossrefGoogle Scholar3. GyoergyGoldblatt PH: Observations on the conditions of dietary hepatic injury (necrosis, cirrhosis) in rats, J. Exper. Med. 75: 375, 1942. Google Scholar4. GyoergyGoldblatt PH: Further observations on the production and prevention of dietary hepatic injury (necrosis, cirrhosis) in rats, J. Exper. Med. 89: 245, 1949. CrossrefMedlineGoogle Scholar5. Webster G: Cirrhosis of the liver among rats receiving diets poor in protein and rich in fat, J. Clin. Investigation 21: 385, 1942. CrossrefMedlineGoogle Scholar6. BlumbergGrady HHS: Production of cirrhosis of the liver in rats by feeding low protein, high fat diets, Arch. Path. 34: 1035, 1942. Google Scholar7. EndicottDaftSebrell KMFSWH: Dietary cirrhosis without ceroid in rats, Proc. Soc. Exper. Biol. and Med. 57: 330, 1944. CrossrefGoogle Scholar8. AshburnEndicottDaftLillie LLKMFSRD: Non-portal distribution of trabeculae in dietary cirrhosis of rats and guinea pigs, Am. J. Path. 23: 159, 1947. MedlineGoogle Scholar9. GlynnHimsworthLinden LEHPH: The experimental production and development of diffuse hepatic fibrosis (portal cirrhosis), Brit. J. Exper. Path. 70: 185, 1948. Google Scholar10. Hartroft WS: The significance of fatty cysts in cirrhosis, Arch. Path. 55: 63, 1953. Google Scholar11. Daft FS: Liver cirrhosis and some dietary factors affecting their development, Ann. New York Acad. Sc. 57: 623, 1954. CrossrefMedlineGoogle Scholar12. PatekPloughBevans AJICM: Relative effects of protein and lipotropic substances in the treatment of nutritional cirrhosis in rats, Ann. New York Acad. Sc. 57: 772, 1954. CrossrefMedlineGoogle Scholar13. Hartroft WS: The sequence of pathologic events in the development of experimental fatty livers and cirrhosis, Ann. New York Acad. Sc. 57: 633, 1954. CrossrefMedlineGoogle Scholar14. WhiteCongdonDavidAlly JCCPWMS: Cirrhosis of the liver in rats following total body x-irradiation, J. Nat. Cancer Inst. 15: 1155, 1955. MedlineGoogle Scholar15. Connor CL: Some effects of chronic alcohol poisoning in rabbits, Arch. Path. 30: 165, 1940. Google Scholar16. RichHamilton ARJD: The experimental production of cirrhosis of the liver by means of a diet deficiency, Bull. Johns Hopkins Hosp. 66: 185, 1940. Google Scholar17. ConnorChaikoff CLIL: Production of cirrhosis in fatty livers with alcohol, Proc. Soc. Exper. Biol. and Med. 39: 356, 1938. CrossrefGoogle Scholar18. ChaikoffConnorBiskind ILCLGR: Fatty infiltration and cirrhosis of the liver in depancreatized dogs maintained with insulin, Am. J. Path. 14: 101, 1938. MedlineGoogle Scholar19. ChaikoffConnor ILCL: Production of cirrhosis of the liver of the normal liver dog by high fat diets, Proc. Soc. Exper. Biol. and Med. 43: 638, 1940. CrossrefGoogle Scholar20. LamsonWing PDR: Early cirrhosis of liver produced in dogs by carbon-tetrachloride, J. Pharmacol. and Exper. Therap. 29: 191, 1926. Google Scholar21. Holman RL: Cirrhosis of the liver in "donor" dogs fed a high fat diet and subjected to repeated bleedings, J. Exper. Med. 81: 399, 1945. CrossrefMedlineGoogle Scholar22. WilgramLucasBest GFCCCH: Kwashiorkor type of fatty liver in primates, J. Exper. Med. 108: 361, 1958. CrossrefMedlineGoogle Scholar23. Report of the board for classification and nomenclature of cirrhosis of the liver, Fifth Pan-American Conference of Gastroenterology, Havana, Cuba, January 20, 1956, Gastroenterology 31: 213, 1956. Google Scholar24. EdwardsMallory JEGK: Mallory's phosphotungstic acid haematoxylin stain for alcoholic hyalin, Bull. Internat. A. M. Mus. 30: 130, 1949. Google Scholar25. Stare FJ: Personal communication, June, 1958. Google Scholar26. Wilgram GF: Unpublished data, 1956-1958. Google Scholar27. Klatskin JD: The role of alcohol in the pathogenesis of cirrhosis, Yale J. Biol. and Med. 26: 23, 1953. MedlineGoogle Scholar28. Dible JH: Fatty change, cirrhosis and liver cancer in Great Britain, Acta Unio internat, contra cancrum 13: 545, 1957. Google Scholar29. Moore RA: Cirrhosis of the liver; causes, in A textbook of pathology, 1952, W. B. Saunders Company, Philadelphia, p. 608. Google Scholar30. Moon VH: Experimental cirrhosis in relation to human cirrhosis, Arch. Path. 18: 381, 1934. Google Scholar31. Vorlaender KO: Ueber den Nachweis komplementbindender Antikoerper bei Nieren und Lebererkrankungen, Ztschr. f. d. ges. exper. Med. 118: 352, 1952. CrossrefMedlineGoogle Scholar32. EatonMurphyHanford MDWDVL: Heterogenic antibodies in acute hepatitis, J. Exper. Med. 79: 539, 1944. CrossrefMedlineGoogle Scholar33. BjorneboeKragLundquist MPF: Complement fixation in hepatitis with some lipids from liver tissue, Acta path. et microbiol. Scandinav. 25: 175, 1948. CrossrefMedlineGoogle Scholar34. ScheiffarthBerg FG: Erfahrungen mit der Kollodium Prezipitinreaktion zum Nachweis von Autoantikoerpern, Klin. Wchnschr. 28: 349, 1950. CrossrefMedlineGoogle Scholar35. GajdusekMackay DCIR: An auto-immune reaction against human tissue antigens in certain acute and chronic diseases, Arch. Int. Med. 101: 9, 1958. CrossrefGoogle Scholar36. Vorlaender KO: Neuere Ergebnisse zum Autoimmunisierungsproblem, Verhandl. deutsch. Gesellsch. inn. Med., Kong. 60: 242, 1954. CrossrefGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Boston, Massachusetts*Received for publication July 7, 1959.Presented at the Fortieth Annual Session of The American College of Physicians, Chicago, Illinois, April 22, 1959.From the Ben May Laboratory for Cancer Research, University of Chicago, and Banting and Best Department of Medical Research, University of Toronto, Canada.Requests for reprints should be addressed to George F. Wilgram, M.D., Harvard University Department of Dermatology, Massachusetts General Hospital, Boston 14, Massachusetts. 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Research carried out by the author has been supported by grants from the National Institutes of Health, Bethesda, Maryland.Methionine-responsive Liver Damage in Young Pigs Fed a Diet Low in Protein and Vitamin EMalnutrition and liver disease—An overemphasized relationshipSome Aspects of the Ultrastructural Pathology of the LiverObservations on Patients with Laennec's Cirrhosis Receiving Alcohol While on Controlled DietsESAT ERENOGLU, M.D., JUAN G. EDREIRA, M.D., ARTHUR J. PATEK JR., M.D.Dietary Factors in the Pathogenesis and Treatment of Cirrhosis of the LiverThe liver and Its Diseases 1 December 1959Volume 51, Issue 6Page: 1134-1158KeywordsCirrhosisGuinea pigsHypertensionLesionsNutritionPathologistsProteinsRabbitsRegenerative medicineResearch laboratories ePublished: 1 December 2008 Issue Published: 1 December 1959 PDF downloadLoading ...