Digitalis: Digoxin Availability, Toxicity
Authors: GORDON M. TRENHOLME
Journal: Annals of Internal Medicine (1973)

Comments and Corrections1 December 1973Digitalis: Digoxin Availability, ToxicityGORDON M. TRENHOLME, M.D.GORDON M. TRENHOLME, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-79-6-908_2 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: In his article, "Digitalis Glycosides" (Ann Intern Med79:229-238, 1973) Dr. Doherty recommends adjustment of digitalis dosage in patients with thyroid disorders. He attributes the alteration in digitalis requirements in these patients to an altered end-organ responsiveness to digoxin. The data he presents in Figure 8 of his article, however, show significant differences in serum concentrations of tritiated digoxin in hypothyroid, hyperthyroid, and euthyroid patients given the same dose of digoxin. The differences in serum digoxin concentrations adequately explain the increased requirement for digoxin in hyperthyroid patients and the decreased requirement for digoxin in hypothyroid patients, without...Reference1. FORDOWENSCURD RJG: Kidney function in various thyroid states. J Clin Endocrinol Metab 21:548-553, 1961 CrossrefMedlineGoogle Scholar1. DOHERTYPERKINS JW: Digoxin metabolism in hypo- and hyperthyroidism. Studies with tritiated digoxin in thyroid disease. Ann Intern Med 64:489-507, 1966 LinkGoogle Scholar1. WAGNERCHRISTENSENSAKMAR JME: Equivalence lack in digoxin plasma levels. JAMA 224:199-204, 1973 CrossrefMedlineGoogle Scholar2. LINDENBAUMMELLOWBLACKSTONE JMM: Variation in biologic availability of digoxin from four preparations. N Engl J Med 285:1344-1347, 1971 CrossrefMedlineGoogle Scholar3. WOTMANBIGGERMANDEL SJI: Salivary electrolytes in the detection of digitalis toxicity. N Engl J Med 285:871-876, 1971 CrossrefMedlineGoogle Scholar4. SWANSONCACACECHUN MLG: Saliva calcium and potassium concentrations in the detection of digitalis toxicity. Circulation 47:736-743, 1973 CrossrefMedlineGoogle Scholar1. DOHERTY J: Digitalis assay by salivary electrolytes (editorial). N Engl J Med 285:1540-1541, 1971 CrossrefGoogle Scholar2. GOULDRAMANA REDDYGOMPRECHT LCR: Evaluation of digitalis toxicity by salivary electrolytes (letter). N Engl J Med 286:47, 1972 CrossrefMedlineGoogle Scholar3. FOGELMANLA MONTFINKLESTEIN AJS: Fallibility of plasma-digoxin in differentiating toxic from non-toxic patients. Lancet 2:727-729, 1971 CrossrefMedlineGoogle Scholar4. JOHNSONGREERMCCRERIE BH: Rate of dissolution of digoxin tablets as a predictor of absorption. Lan cet 1:1473-1475, 1973 CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: GORDON M. TRENHOLME, M.D.Affiliations: Walter Reed Army Institute of Research Duty Station: Laboratory for Tropical Diseases Joliet, Illinois PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 December 1973Volume 79, Issue 6Page: 908-910KeywordsAttentionGlycosidesThyroid diseasesToxicity ePublished: 1 December 2008 Issue Published: 1 December 1973 PDF downloadLoading ...