tbuckley/cabot-search huggingface dataset:
Corneal Arc Full Circle
Authors: RICHARD C. KEECH
Journal: Annals of Internal Medicine (1968)

Letters and Comments1 June 1968Corneal Arc Full CircleRICHARD C. KEECHRICHARD C. KEECHSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-68-6-1369_1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the Editor: I have read with interest the article "Arcus Not So Senilis," which appeared in the ANNALS OF INTERNAL MEDICINE in February 1968, and the letters of comment in the April 1968 number.Deposits of lipoid material in the periphery of the cornea near the sclera frequently form incomplete circles, and therefore may properly be called arcs. Both of the examples of arcus senilis in Adams' Physical Diagnosis, 14th edition, p. 89, are of this sort. And a circle might be considered an arc with 360 deg of curvature.I vote for the terms "arcus corneae" and "corneal...Reference1. WILKINSON CF, HAND EA, and FLIEGELMAN MT: Essential familial hypercholesterolemia. Ann. Intern. Med. 29: 671, 1948. LinkGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: RICHARD C. KEECH PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 June 1968Volume 68, Issue 6 Page: 1369-1369 Keywords Cornea ePublished: 1 December 2008 Issue Published: 1 June 1968 PDF downloadLoading ...
Determination of sulfur trioxide in engine exhaust.
Authors: D R Arnold
Journal: Environmental Health Perspectives (1975)

Sulfur trioxide in the exhaust gas of an internal combustion engine is removed and concentrated by absorption in a solution of 80% isopropyl alcohol, which quantitatively absorbs it and inhibits the oxidation of any sulfur dioxide which may be absorbed. The absorbed sulfur trioxide (sulfuric acid) is determined by an absorption titration by using barium chloride as the titrant and thorin as the indicator. The sulfur dioxide content of the exhaust is measured continuously by means of a DuPont Model 411 ultraviolet photoanalyzer.
European LeukemiaNet criteria for failure or suboptimal response reliably identify patients with CML in early chronic phase treated with imatinib whose eventual outcome is poor
Authors: David Marin, Dragana Milojkovic, Eduardo Olavarria, Jamshid S. Khorashad, Hugues de Lavallade, Alistair G. Reid, Letizia Foroni, Katayoun Rezvani, Marco Bua, Francesco Dazzi, Jiri Pavlu, Matthias Klammer, Jaspal S. Kaeda, John M. Goldman, Jane F. Apperley
Journal: Blood (2008)
David Southall: anatomy of a wrecked career
Authors: C. Dyer
Journal: BMJ (2012)

After 14 years in the rifle sights of the General Medical Council, the paediatrician David Southall has now had the final case against him dropped. <b>Clare Dyer</b> unpicks how he was failed by the regulatory system and what steps have been taken to make sure no other doctor has to go through such an ordeal
Hepatic carbonic anhydrase inhibition by diuretic drugs
Authors: Thomas H. Maren
Journal: Hepatology (1987)

1. In isolated perfused rat liver, urea synthesis is rapid and reversibly inhibited not only by the well-known carbonic anhydrase inhibitors acetazolamide, methazolamide and ethoxzolamide, but also by diuretics, like xipamide, mefruside, chlortalidone, and chlorothiazide. Furosemide was without effect. 2. Similar to findings with isolated perfused rat liver, acetazolamide inhibits urea synthesis from ammonium ions in normal and cirrhotic human liver slices. 3. Inhibition of urea synthesis by xipamide and acetazolamide is accompanied by a 70% decrease of the cellular citrulline content and the tissue levels of 2-oxoglutarate and citrate, suggesting a block of urea synthesis at a step prior to citrulline formation. 4. At a constant extracellular pH (7.4), inhibition of urea synthesis by xipamide, mefruside and acetazolamide was overcome by increasing the extracellular concentrations of HCO 3 − and CO 2 to above twice the normal values. This shows that inhibition of urea synthesis by these diuretics is not due to an unspecific inhibition of one of the urea cycle enzymes but is due to an inhibition of mitochondrial carbonic anhydrase and therefore due to an impaired HCO 3 − provision for mitochondrial carbamoylphosphate synthesis. 5. It is concluded that the activity of mitochondrial carbonic anhydrase is required for urea synthesis also in human liver and that several diuretics impair urea synthesis by inhibition of mitochondrial carbonic anhydrase. The pathophysiological significance of these data is discussed with respect to the development of diuretics-induced hyperammonemia and alkalosis in liver disease.
INDIUM-111 LEUKOCYTE SCANNING AS AN AID IN THE DIAGNOSIS OF INFLAMMATORY BOWEL DISEASE
Authors: Philip F. Cohen, Peter Hicken, W. John Zohrab, Don Lyster
Journal: Clinical Nuclear Medicine (1984)

Fourteen patients suspected of having inflammatory bowel disease at Lion's Gate Hospital were studied with radiologic tests and fiberoptic endoscopy. Additionally all patients were studied with Indium-111 labelled leukocytes, which has been proposed as a useful tracer for the diagnosis of inflammatory bowel disease. Eleven of fourteen patients who were biopsied positive for either Crohn's disease or colitis were also positive utilizing the Indium-111 leukocyte technique. Five patients were negative with the Indium-111 leukocyte study and were felt either by biopsy or clinically to be negative for inflammatory bowel disease. A quantitative index of leukocyte accumulation in diseased bowel segments was derived using temporal subtraction of two hour from twenty-four hour Indium-111 images. Using this index, there was good separation of IBD patients from negative controls. This technique appears useful in assessing the severity of inflammatory bowel disease and provides the first objective means to our knowledge of quantitating the inflammatory changes in Crohn's or ulcerative colitis.
Combined treatment of solar urticaria with plasmapheresis and PUVA
Authors: M.J. HUDSON-PEACOCK, P.M. FARR, B.L. DIFFEY, T.H.J. GOODSHIP
Journal: British Journal of Dermatology (1993)

We describe a patient suffering from severe solar urticaria, unresponsive to conventional treatments, in whom a circulating photoallergen was demonstrated, and who subsequently responded to treatment with a combination of plasmapheresis and PUVA.
Mary Putnam Jacobi
Authors: Paul J. Davis
Journal: New England Journal of Medicine (1965)

MARY Corinna Putnam Jacobi was born in 1842, the eldest daughter of a New York publisher, G. P. Putnam. She was the first female student accepted by l'École de Médecine (1868) and the first female physician in the New York Academy of Medicine. Elizabeth Garrett and Ann Preston were contemporaries, and Sophia Jex-Blake was a correspondent. Dr. Jacobi was regarded as the most accomplished woman physician of her era, described by Sir William Osler as having "a Paris medical degree and a training in scientific medicine unusual at that date even among men."1 She was also an author of romantic . . .
Epidemiology of Childhood Type I Diabetes in Sudan, 1987–1990
Authors: Abdelaziz Elamin, Mohamed I A Omer, Kamel Zein, Torsten Tuvemo
Journal: Diabetes Care (1992)

OBJECTIVE To determine the incidence of type I diabetes in children 0–14 yr of age in Khartoum, Sudan. RESEARCH DESIGN AND METHODS Prospective registration of newly diagnosed patients in a hospital-based registry with independent validation of completeness of case ascertainment. Eligible patients were Sudanese children &amp;lt; 15 yr of age, who developed type I diabetes during the period 1 January 1987 through 31 December 1990, and who were living in Khartoum city at the time of diagnosis. The denominator is the stable childhood population of Khartoum city, as estimated by the National Bureau of Statistics. RESULTS In 4 yr, 239 cases were notified in the primary source and 268 in the secondary source. Some 196 patients were registered in both sources. Using the capture-recapture method to correct for underascertainment, the estimated total number of cases was 327, and the overall degree of ascertainment was 95%. The incidence of type I diabetes in children 0–14 yr of age increased from 5.9/105) in 1987 to 10.1/105) in 1990 (P &amp;lt; 0.001). Girls exhibited slightly higher incidence rates than boys in the 10–14-yr age-group throughout the 4 yr, but the differences were not statistically significant. The age distribution at onset was bimodal with a clear peak at age 12 yr in girls and age 14 yr in boys and another smaller peak at age 7 yr in both sexes. The number of new cases was markedly higher in the cooler months of the year, with a peak in January and a nadir in June (P &amp;lt; 0.01). This trend was consistent over the period of observation. CONCLUSIONS Childhood diabetes is increasing in Sudan. Our incidence figures are higher than those reported from other Arab countries and is similar to reports from France and Italy.
In England starving your child would amount to "criminal neglect"
Authors: J. Murphy
Journal: BMJ (1996)

From a legal perspective, Mok and Nelson's article touches on three interesting questions all of which, regrettably, the authors fail fully to address. First, there is the issue of whether children can be compelled to eat against either their own wishes or those of their parents. Secondly, the authors address on the question of whether parents who starve their children are engaging in a form of “child abuse.” Finally, their article provokes, but fails to engage in, discussion of a key question concerning the impact of international conventions on domestic laws.

In relation to the first matter, the authors are apt to mislead when they claim that the 1989 Children Act states the rights of children to make an informed decision in medical intervention that concerns them. The 1989 act does no more than confer a …
Cerebrospinal fluid levels of matrix metalloproteinase-9 and tissue inhibitor of metalloproteinase-1 in subacute sclerosing panencephalitis
Authors: Takashi Ichiyama, Takeshi Matsushige, Peter Siba, Dagwin Suarkia, Toshiaki Takasu, Kenji Miki, Susumu Furukawa
Journal: Journal of Infection (2008)
Screening for Melanoma and Skin Cancer
Authors: Faye D. Arundell
Journal: JAMA (1986)

<h3>To the Editor.—</h3> A recent critique of screening procedures at health fairs by Donald M. Berwick, MD,<sup>1</sup>in the Sept 20, 1985, issue has been interpreted by the lay press as a negative review of health fairs (<i>Chicago Sun-Times</i>, Sept 20, 1985). It would be unfortunate to have negative reviews overshadow effective and efficient screening programs. Screening for hypertension and colorectal cancer was found by Berwick to be "soundly linked with a plausible chain of events leading from early detection to improved health." The criteria for screening to be effective and efficient were met, at least in part, by blood pressure and fecal occult blood testing. Screening for melanoma and skin cancer, although not reviewed by Berwick, also meets his criteria, which are as follows: (1) The disease must be widespread and unlikely to be detected without screening. (2) Screening must have a low error rate and be low
Prognostic Effect of Sesrum 25 Hydroxyvitamin D Levels in Breast Cancer Patients.
Authors: H. Kim, W. Lim, B. Son, M. Kim, K. Jeong, S. Kim, J. Ahn, G. Gong, H. Kim, C. Yeom, S. Ahn
Journal: Cancer Research (2009)

Abstract BackgroundThere is increasing evidence that vitamin D has been linked to breast cancer risk, but prognosis effect are unknown. We investigated the possible association between vitamin D and breast cancer prognosis by comparing serum vitamin D levelMethodsFrom June to December 2006, serum 25 OHD were measured in 310 Korean women with breast cancer at the Asan Medical Center. Clinical, Pathologic, and dietary data were accessed to examine prognostic effects of serum 25 OHDResultsMean age was 48.7 years, mean serum 25OHD was 31.4±16.1ng/ml. 25OHD levels were deficient(&amp;lt;20ng/ml) in 24.2%, insufficient (20-29ng/ml) in 30.6%, and sufficient(30-150ng/ml) in 24.0%. Mean follow up was 30 months: 31 had recurrences. Women with deficient 25 OHD levels had an increased risk of recurrence(HR=2.93;95% CI=1.27 to 6.77) compared with those with sufficient levels. 25OHD levels were inversely associated with prognosis of hormone receptor positive tumors, but not with hormone receptor negative tumors(HR=5.73 95CI=1.82 to 18.06 for hormone receptor positive tumor, HR=1.142, 95%CI =0.33 to 3.92 for hormone receptor negative tumor). The association remained after individual adjustment for age, tumor size, nodal status, estrogen receptor status (HR=4.13 95%CI=1.77 to 9.61) .ConclusionVitamin D deficiency may be associated with poor outcomes in hormone receptor positive breast cancer patients. Citation Information: Cancer Res 2009;69(24 Suppl):Abstract nr 1052.
Difficulties in Assessing Dementia
Authors: JOHN JOSEPH LA PUMA
Journal: Annals of Internal Medicine (1985)

Letters and Corrections1 September 1985Difficulties in Assessing DementiaJOHN JOSEPH LA PUMA, M.D.JOHN JOSEPH LA PUMA, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-103-3-470_1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: I have just completed an internal medicine residency in an institution where the ravages of old age are often uncomfortably apparent to health care workers. Severely demented patients are among the most difficult to take care of. Their problems are many and their likelihood of recovery small. As physicians, we often feel helpless with them. How to be humane to these patients raises complex problems.Dr. Rango's (1) thoughtful article tries to help us be humane. In it, he sets forth criteria for limiting the medical care given to demented patients. Rango describes the "absence of the...Reference1. RANGO N. The nursing home resident with dementia; clinical care, ethics, and policy implications. Ann Intern Med. 1985; 102:835-41. LinkGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: JOHN JOSEPH LA PUMA, M.D.Affiliations: The University of Chicago Chicago, IL 60637 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 September 1985Volume 103, Issue 3 Page: 470-470 Keywords Dementia Health care providers Residency ePublished: 1 December 2008 Issue Published: 1 September 1985 PDF downloadLoading ...
ACUTE LYMPHOCYTIC LEUKAEMIA: RECOVERY AFTER INTRAMUSCULAR INJECTIONS OF HOG SPLEEN
Authors: R. M. Pearce
Journal: BMJ (1930)

BRITISRI have been told bw miany that a blood tiansfusioll should not be givenl to a patient witli pernicious ailaemia whlo is runninlg a high temi)erat e, but I have repeatedly gi-ven -500 c.rnl. of blood to patients witlh a temperature of. 1020F., anid'so far I lhave Iiot la(l a severe reaction either in cases where both donor anid recil)ient were of the same gioup), or where the donolr belonged to Gr-oup IV andl the patient was of another group.In most cases of pernicious anaemia, anid in all cases where l)atients have a temperature, I give liquor arseinicalis
CATHETER-DELIVERABLE HYDROGEL DERIVED FROM DECELLULARIZED VENTRICULAR EXTRACELLULAR MATRIX INCREASES CARDIOMYOCYTE SURVIVAL AND PRESERVES CARDIAC FUNCTION POST-MYOCARDIAL INFARCTION
Authors: Karen L. Christman, Jennifer M. Singelyn, Michael Salvatore, Pamela J. Schup-Magoffin, Diane P. Hu, Todd Johnson, Kendra Bartels, Anthony N. DeMaria, Nabil Dib
Journal: Journal of the American College of Cardiology (2011)
87 Prediction of liver fibrosis in non-alcoholic steatohepatitis (NASH): Risk factors and diagnostic potential of liver elasticity using fibroscan
Authors: V. de Ledinghen, M. Beaugrand, T.B. Kelleher, J. Foucher, L. Castera, M. Ziol, N. Ganne, M. Lai, N.H. Afdhal
Journal: Journal of Hepatology (2006)
Long-term outcome of Rheumatoid Arthritis defined according to the 2010-classification criteria
Authors: L E Burgers, J A B van Nies, L Y Ho, D P C de Rooy, T W J Huizinga, A H M van der Helm-van Mil
Journal: Annals of the Rheumatic Diseases (2013)

The 2010 American College of Rheumatology/European League Against Rheumatism (ACR/EULAR) criteria for rheumatoid arthritis (RA) have been thoroughly studied for the test characteristics but it is unclear whether '2010 RA' has a different phenotype than '1987 RA' when assessing the severity of the disease course. Therefore this study compared two long-term disease outcomes.1502 early arthritis patients that had no other diagnoses than RA or undifferentiated arthritis (UA) were studied on fulfilling the 1987 ACR criteria, 2010 criteria or both. The severity of joint damage was studied with yearly radiographs over 7 years. Achieving disease-modifying anti-rheumatic drug (DMARD)-free sustained remission was assessed over 10-years follow-up. Multivariate normal regression and Cox-proportional hazard regression were used, adjusting for age, gender and treatment.550 patients fulfilled the 1987 criteria, 788 patients the 2010 criteria and 489 both criteria sets. Patients fulfilling the 2010 criteria developed less severe radiological joint damage (p=0.023) and achieved DMARD-free sustained remission more often (HR=1.18 (0.93-1.50)) than patients fulfilling the 1987 criteria, though the latter was not statistically significant. All 1987+2010- patients were anti-citrullinated peptide antibody (ACPA)-negative. When also applying the radiologic criterion of the 2010-criteria, half of the 1987+2010- patients became 2010 criteria positive, but results on the long-term outcome remained similar.'2010 RA' has a milder disease course than '1987 RA'. This may have important implications for basic scientific studies and clinical trials in RA.
A Novel Abundant Family of Retroposed Elements (DAS-SINEs) in the Nine-Banded Armadillo (Dasypus novemcinctus)
Authors: G. Churakov
Journal: Molecular Biology and Evolution (2004)

About half of the mammalian genome is composed of retroposons. Long interspersed elements (LINEs) and short interspersed elements (SINEs) are the most abundant repetitive elements and account for about 21% and 13% of the human genome, respectively. SINEs have been detected in all major mammalian lineages, except for the South American order Xenarthra, also termed Edentata (armadillos, anteaters, and sloths). Investigating this order, we discovered a novel high-copy-number family of tRNA derived SINEs in the nine-banded armadillo Dasypus novemcinctus, a species that successfully crossed the Central American land bridge to North America in the Pliocene. A specific computer algorithm was developed, and we detected and extracted 687 specific SINEs from databases. Termed DAS-SINEs, we further divided them into six distinct subfamilies. We extracted tRNA(Ala)-derived monomers, two types of dimers, and three subfamilies of chimeric fusion products of a tRNA(Ala) domain and an approximately 180-nt sequence of thus far unidentified origin. Comparisons of secondary structures of the DAS-SINEs' tRNA domains suggest selective pressure to maintain a tRNA-like D-arm structure in the respective founder RNAs, as shown by compensatory mutations. By analysis of subfamily-specific genetic variability, comparison of the proportion of direct repeats, and analysis of self-integrations as well as key events of dimerization and deletions or insertions, we were able to delineate the evolutionary history of the DAS-SINE subfamilies.
Spectrum of Asthma in Children--II, Allergic Components
Authors: K. N. McNichol, H. E. Williams
Journal: BMJ (1973)

The incidence of a variety of clinical and immunological features of an allergic state was studied at 7, 10, and 14 years of age in a group of children suffering from one of four grades of asthma, ranging from mild subclinical to severe unremitting, and compared with the incidence in a control group of non-asthmatic children. The incidence of all features of allergy was significantly higher in the asthmatics but no one feature unequivocally distinguished the asthmatics from the controls. Almost all the asthmatics showed several features of the allergic state at 14 years of age. A cluster of allergic features was a differentiating characteristic of the asthmatics, and the children with the most allergic manifestations were usually the children with the most severe and persistent asthma. The first appearance of and subsequent variation in some of the allergic manifestations often did not correspond to the clinical course of the asthma.Though many manifestations of asthma can be understood on an allergic basis the mechanism by which emotional disturbance, exercise, viral infections, and non-allergenic stimuli precipitate attacks of asthma and the relation of these factors to allergy are unknown.
Next generation RNA‐sequencing in prognostic subsets of chronic lymphocytic leukemia
Authors: Larry Mansouri, Rebeqa Gunnarsson, Lesley‐Ann Sutton, Adam Ameur, Sean D Hooper, Markus Mayrhofer, Gunnar Juliusson, Anders Isaksson, Ulf Gyllensten, Richard Rosenquist
Journal: American Journal of Hematology (2012)

Advances in next-generation RNA-sequencing have revealed the complexity of transcriptomes by allowing both coding and noncoding(nc)RNAs to be analyzed. However, limited data exist regarding the whole transcriptional landscape of chronic lymphocytic leukemia(CLL). In this pilot-study, we evaluated RNA-sequencing in CLL by comparing two subsets which carry almost identical or "stereotyped" B-cell receptors with distinct clinical outcome, that is the poor-prognostic subset #1 (n 5 4) and the more favorable-prognostic subset #4(n 5 4). Our analysis revealed that 156 genes (e.g. LPL, WNT9A) and 76 ncRNAs, (e.g. SNORD48, SNORD115) were differentially expressed between the subsets. This technology also enabled us to identify numerous subset-specific splice variants (n 5 406), which were predominantly expressed in subset #1, including a splice-isoform of MSI2 with a novel start exon. A further important application of RNA-sequencing was for mutation detection and revealed 16–30 missense mutations per sample; notably many of these changes were found in genes with a strong potential for involvement in CLL pathogenesis, e.g., ATM and NOTCH2.This study not only demonstrates the effectiveness of RNA-sequencing for identifying mutations, quantifying gene expression and detecting splicing events, but also highlights the potential such global approaches have to significantly advance our understanding of the molecular mechanisms behind CLL development.
In-flight Deaths During Commercial Air Travel
Authors: Richard O. Cummins, Peter J. C. Chapman, Douglas A. Chamberlain, Jessica A. Schubach, Paul E. Litwin
Journal: JAMA (1988)

Do passenger deaths occur during commercial air travel? If so, how often and from what causes? We reviewed information reported to the International Air Transport Association on in-flight deaths that occurred during commercial air travel for the eight years between 1977 and 1984. Of the 120 airlines in the International Air Transport Association, 42 carriers reported deaths during these eight years. A total of 577 in-flight deaths were recorded, for a reported average of 72 deaths per year. Deaths occurred at average rates of 0.31 per million passengers, 125 per billion passenger-kilometers, and 25.1 per million departures. The majority of those who died were men (66%, 382/577) and middle-aged (mean age, 53.8 years). Most of the individuals (77%, 399/515) reported no health problems prior to travel. Physicians aboard the aircraft offered medical assistance for 43% (247/577) of the deaths. More than half of the deaths (56%, 326/577) seemed to be related to cardiac problems. Sudden unexpected cardiac death was the cause of death in 63% (253/399) of the apparently healthy people and seems to be the major cause of death during air travel. These observations support the initiation of programs to train cabin personnel in the skills of basic cardiopulmonary resuscitation and in the use of automatic external defibrillators.