OBSERVATIONS UPON THE EXPERIMENTAL AND CLINICAL USE OF SULFAPYRIDINE. III. THE MECHANISM OF RECOVERY FROM PNEUMOCOCCAL PNEUMONIA IN PATIENTS TREATED WITH SULFAPYRIDINE
Authors: W. Barry Wood, Perrin H. Long
Journal: Annals of Internal Medicine (1939)

Article1 October 1939OBSERVATIONS UPON THE EXPERIMENTAL AND CLINICAL USE OF SULFAPYRIDINE. III. THE MECHANISM OF RECOVERY FROM PNEUMOCOCCAL PNEUMONIA IN PATIENTS TREATED WITH SULFAPYRIDINEW. BARRY WOOD JR., M.D., PERRIN H. LONG, M.D.W. BARRY WOOD JR., M.D., PERRIN H. LONG, M.D.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-13-4-612 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptIt has been established by a number of investigators1, 2, 3, 4, 5that sulfapyridine exercises a bacteriostatic effect upon pneumococci in vitro. Fleming1has shown that the growth of pneumococci in human whole blood is inhibited by sulfapyridine, but that in the absence of leukocytes the organisms are not destroyed. When leukocytes are present in the blood-sulfapyridine preparations, the growth of pneumococci is not only inhibited, but in many instances the blood is rendered sterile, probably as a result of the combined action of the sulfapyridine and the natural antibacterial substances in the serum. If type-specific pneumococcal antiserum is...Bibliography1. FLEMING A: The antibacterial action in vitro of 2(p-aminobenzenesulphonamido) pyridine on pneumococci and streptococci, Lancet, 1938, ii, 74. CrossrefGoogle Scholar2. BLISSLONG EAPH: Comparison of bacteriostatic effects of sulfanilamide and sulfapyridine (2 sulfanilyl aminopyridine) on bacteria in broth cultures, Proc. Soc. Exper. Biol. and Med., 1938, xxxix, 483. CrossrefGoogle Scholar3. LONGBLISSFEINSTONE PHEAWH: The effect of sulfapyridine, sulfanilamide and related compounds in bacterial infections, Pennsylvania Med. Jr., 1939, xlii, 483. Google Scholar4. LONGBLISS PHEA: The relation of strain resistance to the chemotherapeutic effects of sulfapyridine in experimental infections in mice, ANN. INT. MED., 1939, xiii, 232. Google Scholar5. MCINTOSHWHITBY JLE: The mode of action of the drugs of the sulphonamide group, Lancet, 1939, i, 413. Google Scholar6. LONG PH: Unpublished observations. Google Scholar7. EVANSGAISFORD GMWF: Treatment of pneumonia with 2(p-aminobenzenesulphonamido) pyridine, Lancet, 1938, ii, 14. CrossrefGoogle Scholar8. AGRANATDREOSTIORDMAN ALAOD: Treatment of pneumonia with 2(p-aminobenzenesulphonamido) pyridine (M. & B. 693), Lancet, 1939, i, 309. CrossrefGoogle Scholar9. ALSTED G: Type III pneumococcal pneumonia, effect of M. & B. 693, Lancet, 1939, i, 869. CrossrefGoogle Scholar10. LONGWOOD PHWB: The treatment of pneumococcal pneumonia with sulfapyridine, ANN. INT. MED., 1939, xxiii, 487-529. Google Scholar11. ROBERTSONGRAESERCOGGESHALLHARRISON OHJBLTMA: Relation of circulating antipneumococcal immune substances to the course of lobar pneumonia. II. Acquired immune substances, Jr. Clin. Invest., 1934, xiii, 633. CrossrefGoogle Scholar12. FRANCIS T: The value of the skin test with type-specific capsular polysaccharide in the serum treatment of type I pneumococcus pneumonia, Jr. Exper. Med., 1933, lvii, 617. CrossrefGoogle Scholar13. MACLEODHOAGLANDBEESON CMCLPB: The use of the skin test with type-specific polysaccharide in the control of serum dosage in pneumococcal pneumonia, Jr. Clin. Invest., 1938, xvii, 739. CrossrefGoogle Scholar14. WOOD WB: The control of the dosage of antiserum in the treatment of pneumococcic pneumonia. I. A study of the mechanism of the skin reaction to type-specific polysaccharide. II. The clinical application of Dr. Francis' skin test. To be published. Google Scholar15. SIAROBERTSONWOOCHEER RHOHSTSN: The occurrence of antipneumococcus substances in the blood serum in lobar pneumonia, Proc. Soc. Exper. Biol. and Med., 1925, xxii, 406. CrossrefGoogle Scholar16. LORDNESCHE FTGE: Antibody and agglutinin in pneumococcus pneumonia, Jr. Exper. Med., 1929, l, 449. CrossrefGoogle Scholar17. LANGLEYMACHAYSTANT GJWL: Studies in pneumonia with special reference to agglutinins, Quart. Jr. Med., 1936, v, 251. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Baltimore, Maryland*Received for publication July 1, 1939.From the Biological Division, The Department of Medicine, The Johns Hopkins University, Baltimore, Maryland.This investigation was supported by a grant from The Chemical Foundation, Inc., of New York City. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byNanotechnology as a Novel Approach in Combating Microbes Providing an Alternative to AntibioticsMicrobes and MetchnikoffSurface Phagocytosis—Its Relation to the Mechanism of Recovery in Pneumococcal PneumoniaThe Treatment of Pulmonary Infections with Sulfanilamide, Sulfapyridine, and Sulfathiazole 1 October 1939Volume 13, Issue 4Page: 612-617KeywordsBloodExercisePneumonia ePublished: 1 December 2008 Issue Published: 1 October 1939 PDF downloadLoading ...