tbuckley/cabot-search huggingface dataset:
Abstract 1337: Traditional Chinese Medicine Prevent Delirium and Save the Cost in Cardiovascular Patients in the Intensive Care Unit
Authors: Jun Matsumoto, Hiroaki Ushikoshi, Shusaku Miyata, Chiharu Yokoyama, Takatomo Watanabe, Tomonori Kawaguchi, Toshiaki Takeyama, Takahide Nawa, Shinsuke Ojio, Shinji Ogura, Shinya Minatoguchi
Journal: Circulation (2009)
Caveolin‐1 Deficiency May Predispose African Americans to Systemic Sclerosis–Related Interstitial Lung Disease
Authors: Charles Reese, Beth Perry, Jonathan Heywood, Michael Bonner, Richard P. Visconti, Rebecca Lee, Corey M. Hatfield, Richard M. Silver, Stanley Hoffman, Elena Tourkina
Journal: Arthritis & Rheumatology (2014)

Interstitial lung disease (ILD) is the leading cause of death in patients with systemic sclerosis (SSc; scleroderma). Although SSc-related ILD is more common and severe in African Americans than in Caucasians, little is known about factors underlying this significant health disparity. The aim of this study was to examine the role that low expression of caveolin-1 might play in susceptibility to ILD among African Americans.Assays of monocyte migration toward stromal cell-derived factor 1 (SDF-1) were performed using monocytes from Caucasian and African American healthy donors and patients with SSc. For fibrocyte differentiation studies, total peripheral blood mononuclear cells were incubated on fibronectin-coated plates. Protein expression was evaluated by immunohistochemistry and Western blotting.Monocytes from healthy African American donors and those from patients with SSc had low caveolin-1 levels, enhanced migration toward the CXCR4 ligand SDF-1, and enhanced differentiation to fibrocytes. Enhanced migration and differentiation of monocytes from African Americans and patients with SSc appeared to be attributable to the lack of caveolin-1, because restoring caveolin-1 function using a caveolin-1 scaffolding domain peptide inhibited these processes. Although they differed from monocytes from Caucasians, monocytes from both African Americans and patients with SSc were not identical, because SSc monocytes showed major increases from baseline in ERK, JNK, p38, and Smad2/3 activation, while monocytes from African Americans showed only limited ERK activation and no activation of JNK, p38, or Smad2/3. In contrast, SDF-1 exposure caused no additional ERK activation in SSc monocytes but did cause significant additional activation in monocytes from African Americans.African Americans may be predisposed to SSc-related ILD due to low baseline caveolin-1 levels in their monocytes, potentially affecting signaling, migration, and fibrocyte differentiation. The monocytes of African Americans may lack caveolin-1 due to high levels of transforming growth factor β in their blood.
A multicenter, phase II study of maintenance azacitidine in older patients with acute myeloid leukemia in complete remission after induction chemotherapy
Authors: Patrick T. Griffin, Rami S. Komrokji, Carlos M. De Castro, David A. Rizzieri, Magda Melchert, Alan F. List, Jeffrey E. Lancet
Journal: American Journal of Hematology (2015)

Older patients with acute myeloid leukemia (AML) have poor outcomes, with median durations of complete remission lasting less than 1 year. Increased toxicity in older patients limits the delivery of standard consolidation therapies, such as allogeneic stem cell transplant or high‐dose cytarabine. Azacitidine, a nucleoside analog/DNA methyltransferase inhibitor, has demonstrated significant activity and favorable tolerability in patients unable to tolerate intensive induction chemotherapy; however, the role of azacitidine in the maintenance setting has not been fully evaluated. We undertook a pilot study of low‐dose subcutaneous azacitidine [50 mg/(m 2 day)] for 5 days every 4 weeks) in AML patients ≥60 years of age in first remission following standard induction therapy. The primary objective was to determine the 1‐year disease‐free survival (DFS); secondary objectives were to determine safety and tolerability. We enrolled 24 patients (median age 68, range 62–81 years), the majority of whom received anthracycline‐cytarabine induction regimens. From the time of first complete remission, the estimated 1‐year DFS was 50% and the median overall survival was 20.4 months. Thrombocytopenia and neutropenia were the most common grade 3/4 toxicities (50 and 58%, respectively). In our study population, maintenance therapy with subcutaneous azacitidine was safe and well tolerated. Am. J. Hematol. 90:796–799, 2015. © 2015 Wiley Periodicals, Inc.
Exercise Programs for Cancer-Related Fatigue: Evidence and Clinical Guidelines
Authors: Margaret L. McNeely, Kerry S. Courneya
Journal: Journal of the National Comprehensive Cancer Network (2010)

This article provides an overview of the research literature and clinical recommendations on aerobic and resistance exercise programs for managing cancer-related fatigue (CRF). Current research evidence suggests that exercise improves CRF, with more recent evidence suggesting greater benefits when exercise programs are administered in the survivorship phase than in the active treatment phase. Moreover, positive changes in fitness from aerobic exercise programs have been shown to mediate the effects of exercise on CRF. Resistance exercise programs show promise in ameliorating CRF, especially in patients with prostate cancer, and should be considered a potential component of the exercise program. Future trials should examine the potential mechanisms through which exercise influences symptoms of CRF and the effect of exercise on CRF in the long-term. More research is needed evaluating exercise programs for cancer survivors with CRF, especially those with moderate-to-severe CRF.
Diagnosis, management and outcome of Candida endocarditis
Authors: A. Lefort, L. Chartier, B. Sendid, M. Wolff, J.-L. Mainardi, I. Podglajen, M. Desnos-Ollivier, A. Fontanet, S. Bretagne, O. Lortholary
Journal: Clinical Microbiology and Infection (2012)
Highlighting risk of diseases is most effective in changing attitudes to vaccines, US study finds:
Authors: Susan Mayor
Journal: BMJ (2015)

Giving people information about the dangers posed by communicable diseases is more persuasive at convincing sceptics of the benefits of vaccination than trying to counter misconceptions about vaccine risks, a US study has shown.

The study, published in the Proceedings of the National Academy of Sciences ,1 asked 315 people recruited through a crowd sourcing website—Amazon Mechanical Turk, which pays people for completing tasks—to fill in a questionnaire testing their attitude to vaccination and other health issues.

The next day the participants were …
Psychiatric Consultations in Clinical Haematology
Authors: M G Clarke, R M Hutchinson, J K Wood
Journal: Journal of the Royal Society of Medicine (1982)

A psychiatrist's role in the management of patients with malignant blood disorders being treated by clinical haematologists is described. Twenty-seven patients were seen, the majority (21) for an initial assessment only, and many (21) within three months of diagnosis or their death. Seventeen were referred for assessment of abnormal mood or behaviour and the others for a variety of problems which affected their management. A small group (4) had organic psychosyndromes; the majority (15) were suffering from understandable adjustment reactions, with another 5 having morbid neurotic or depressive reactions. Family and hospital factors were important and a description of these is included in an account of the consultation process.
Long-term effects of secukinumab on MRI findings in relation to clinical efficacy in subjects with active ankylosing spondylitis: an observational study
Authors: Xenofon Baraliakos, Babul Borah, Juergen Braun, Dominique Baeten, Didier Laurent, Joachim Sieper, Paul Emery, Iain B McInnes, Jacob M van Laar, Paul Wordsworth, Juergen Wollenhaupt, Herbert Kellner, Laurence Colin, Francois Vandenhende, Kath Radford, Wolfgang Hueber
Journal: Annals of the Rheumatic Diseases (2015)

<h3>Introduction</h3> A 28-week study suggested efficacy of the anti-interleukin-17A monoclonal antibody secukinumab in active ankylosing spondylitis (AS). MRI-assessed inflammation was reduced at weeks 6, 28. <h3>Objective</h3> To analyse the longer-term effects of secukinumab on MRI inflammatory and non-inflammatory spinal lesions in relation to its clinical efficacy in subjects with active AS. <h3>Methods</h3> Spinal MRI results (baseline, week 94) for 13 subjects with AS initially treated with secukinumab 2×10 mg/kg intravenously (n=10) or placebo (n=3) and receiving a secukinumab maintenance dose of 3 mg/kg IV every 4 weeks up to week 94 were evaluated by the Berlin score; inflammatory/non-inflammatory (fatty) changes were assessed at vertebral edges (VEs). Results were compared with clinical outcomes. <h3>Results</h3> Most of the 13 subjects assessed at week 94 had sustained clinical responses: 8 (62%) achieved Assessment of SpondyloArthritis international Society 20% (ASAS20), including 6 (46%) achieving ASAS40 responses, corresponding to 75% and 83% reductions in the Berlin score, respectively. In the 10 subjects treated with secukinumab throughout the study period, 79/91 (87%) inflammatory VEs at baseline resolved by week 94; new fatty lesions occurred in 39/796 (4.9%) of VEs; 87/124 (70%) VEs with fatty lesions at baseline remained unchanged; 30% were no longer visible. <h3>Conclusions</h3> In this pilot study, secukinumab treatment up to 2 years yielded sustained clinical improvement accompanied by regression of spinal inflammation. The impact of secukinumab on the development of fatty changes and bone formation in AS will be assessed in larger trials. <h3>Trial registration number</h3> This study is registered with ClinicalTrials.gov, number NCT00809159.
Abstract 14456: Utility of Three-Dimensional Speckle Tracking Radial Strain for Identifying Patients with Cardiac Sarcoidosis
Authors: Takayuki Tsuji, Hidekazu Tanaka, Tatsuya Miyoshi, Mana Hiraishi, Akihiro Kaneko, Keiko Ryo, Yuko Fukuda, Kazuhiro Tatsumi, Kensuke Matsumoto, Hiroya Kawai, Ken-ichi Hirata
Journal: Circulation (2011)

Background: Since cardiac sarcoidosis (CS) caused substantial morbidity and sudden death, early diagnosis and appropriate management for patients with CS are important. Echocardiography was conside...
Quantitative Immunoelectrophoretic Analysis of Rat Allergen Extracts
Authors: Andrew F. Walls, Joan L. Longbottom
Journal: Allergy (1983)

Many constituents of rat fur, urine and saliva were identified as being allergenic using crossed radio‐immunoelectrophoresis with sera from 14 patients who had asthma and rhinitis on exposure to rats. There was considerable diversity in the spectra of components recognised by individual patients, though the majority reacted with immunoprecipitate 4. In all three extacts this represents a similar component, which was originally characterised as a urinary prealbumin. Most of the allergenic components of urine and saliva have also been detected in the fur extract. Some of the minor allergens are those antigens which appear to be unique to urine, saliva or the skin, suggesting that sensitisation to rats can result from exposure to allergenic material from all three of these sources.
Measuring the Effectiveness of Mammography
Authors: Wendy Y. Chen
Journal: JAMA Oncology (2015)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Oncology HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Oncology journal
A novel translocation (x;4)(p22.1;q32) in a child with malignant Schwannoma
Authors: A. M. Cappellano, M. T. Grande, S. N. Oliveira, L. J. G. Zambaldi, M. Araujo, F. A. Freitas, I. A. Cardinalli, S. R. Brandalise, S. S. Aguiar
Journal: Journal of Clinical Oncology (2004)

8572 Background: Malignant Schwannoma is a rare entity that represents 2% of the peripheral nerve sheath tumors. It usually arises from limbs, paravertebral areas or head and neck.It has an aggressive biological behavior with local infiltration and hematogeneous metastases. Multiple cytogenetics aberrations and structural anomalies have been demonstrated by some authors. A novel unreported translocation t(X;4)(p22.1;q32) in a 6 years old boy with malignant paravertebral Schwannoma, without prior exposure to radiotherapy or chemotherapy was diagnosed and demonstrated. Methods: Fresh tumor was minced and digested with Trypsin-EDTA 1:250 for 15 minutes at 37oC. The suspended material was seeded into culture flasks with RPMI medium, 20% fetal calf serum and antibiotics and incubated in 5% CO2 at 37oC. When mitotic activity was identified the cells were harvested and also the tumor within 11 days. Cells were treated with Colquicine 16uL/mL for 3 hours. A hypotonic solution of KCl 0,075M was used for 15 minutes at 37oC. The total of 20 G-banded metaphases cells were analyzed, according to ISCN nomenclature. Results: All the twenty investigated metaphases demonstrated a balanced translocation (X;4)(p22.1;q32) as a single aberration. Although additional molecular breakpoint characterization at 4q32 and Xp22.1 is necessary, a PDGF-C (Platelet-derived Growth Factor C) and FIGF (c-fos-induced growth factor) genes were localized, respectively, in these regions and their involvement seems plausible. Conclusion: Cloning and characterization of the breakpoint region of this tumor may contribute to the discovery of new genes that are important in this rare disease. No significant financial relationships to disclose.
Abstract 3768: Thyroid Function and Mortality in the Sudden Cardiac Death in Heart Failure Trial
Authors: Judith E Mitchell, Anne S Hellkamp, Jill Anderson, George Johnson, Judy Battle, Jeanne E Poole, Daniel B Mark, Kerry L Lee, Gust H Bardy
Journal: Circulation (2006)

Thyroid hormone homeostasis is vital to the optimal functioning of the cardiovascular system. However, conflicting data exist regarding the degree of increased risk associated with thyroid abnormal...
Abstract 11366: Outcomes of Children Supported with the Berlin Heart EXCOR Pediatric VAD: Impact of Patient Characteristics at Implant on Mortality
Authors: Christopher Almond, David Morales, Holger Buchholz, Mark Turrentine, Michiaki Imamura, Patricia Massicotte, James Tweddell, Eric Devaney, Lori Jordan, Kirk Kanter, William Holman, Gordon Cohen, James St. Louis, Khanh Nguyen, Chitra Ravishankar, Henry Walters, Brian Reemsten, Peter Wearden, Olaf Reinhartz, Kristine Guleserian, Max Mitchell, Mark Bleiweis, Charles Canter, Tilman Humpl
Journal: Circulation (2011)

BACKGROUND: Recent data suggests that selected children may benefit from bridge-to-heart transplant support with the Berlin Heart EXCOR Pediatric ventricular assist (VAD). Outcomes of children rece...
Human anthrax in India may be linked to vulture decline
Authors: Ganapati Mudur
Journal: BMJ (2001)

Human anthrax in India may be linked to the decline of vultures. Wildlife scientists in India suspect that a reported resurgence in anthrax among humans in some parts of the country may be linked to a sharp, unprecedented drop in India's population of vultures. Government epidemiologists say, however, that no evidence exists yet for such a link.

Animal anthrax remains endemic in India because inadequate vaccination and lack of cooperation from farmers has kept livestock susceptible to the infection. But the incidence of human …
Hyperfractionated Radiation Therapy With or Without Concurrent Low-Dose Daily Cisplatin in Locally Advanced Squamous Cell Carcinoma of the Head and Neck: A Prospective Randomized Trial
Authors: Branislav Jeremic, Yuta Shibamoto, Biljana Milicic, Nebojsa Nikolic, Aleksandar Dagovic, Jasna Aleksandrovic, Zeljko Vaskovic, Ljiljana Tadic
Journal: Journal of Clinical Oncology (2000)

PURPOSE: To investigate whether the addition of cisplatin (CDDP) to hyperfractionation (Hfx) radiation therapy (RT) offers an advantage over the same Hfx RT given alone in locally advanced (stages III and IV) squamous cell carcinoma of the head and neck. PATIENTS AND METHODS: One hundred thirty patients were randomized to receive either Hfx RT alone to a tumor dose of 77 Gy in 70 fractions in 35 treatment days over 7 weeks (group I, n = 65) or the same Hfx RT and concurrent low-dose (6 mg/m 2 ) daily CDDP (group II, n = 65). RESULTS: Hfx RT/chemotherapy offered significantly higher survival rates than Hfx RT alone (68% v 49% at 2 years and 46% v 25% at 5 years; P = .0075). It also offered higher progression-free survival (46% v 25% at 5 years; P = .0068), higher locoregional progression-free survival (LRPFS) (50% v 36% at 5 years; P = .041), and higher distant metastasis-free survival (DMFS) (86% v 57% at 5 years; P = .0013). However, there was no difference between the two treatment groups in the incidence of either acute or late high-grade RT-induced toxicity. Hematologic high-grade toxicity was more frequent in group II patients. CONCLUSION: As compared with Hfx RT alone, Hfx RT and concurrent low-dose daily CDDP offered a survival advantage, as well as improved LRPFS and DMFS.
Long‐Term Safety of Subcutaneous Abatacept in Rheumatoid Arthritis: Integrated Analysis of Clinical Trial Data Representing More Than Four Years of Treatment
Authors: Rieke Alten, Jeffrey Kaine, Edward Keystone, Peter Nash, Ingrid Delaet, Mark C. Genovese
Journal: Arthritis & Rheumatology (2014)

To investigate the safety of long-term subcutaneous (SC) abatacept treatment using integrated clinical trial data obtained in patients with rheumatoid arthritis refractory to traditional disease-modifying antirheumatic drugs.Data from the double-blind and open-label phases of 5 clinical trials of SC abatacept were pooled. The overall and 6-month incidence rates were calculated as events per 100 patient-years of exposure.This analysis included 1,879 patients with 4,214.6 patient-years of exposure to SC abatacept. The mean ± SD length of exposure was 27.3 ± 9.1 months. The reported incidence rate of serious infections was 1.79 (95% confidence interval [95% CI] 1.42-2.24); the most frequent infections were pneumonia (incidence rate 0.36 [95% CI 0.22-0.59]), urinary tract infection (incidence rate 0.14 [95% CI 0.06-0.32]), and gastroenteritis (incidence rate 0.10 [95% CI 0.04-0.25]). Tuberculosis occurred rarely (incidence rate 0.09 [95% CI 0.04-0.25]). The reported incidence rate of malignancies was 1.32 (95% CI 1.01-1.72), and the most common was solid organ malignancy (incidence rate 0.69 [95% CI 0.48-0.99]). The incidence rate of autoimmune events was 1.37 (95% CI 1.06-1.78), and the most frequent events were psoriasis (incidence rate 0.33 [95% CI 0.20-0.56]) and Sjögren's syndrome (incidence rate 0.24 [95% CI 0.13-0.44]). The reported incidence rate of local injection site reactions was 1.72 (95% CI 1.36-2.17); these events occurred primarily during the first 6 months of treatment, and almost all were of mild or moderate intensity. The incidence rates of serious infections, malignancies, autoimmune events, and injection site reactions did not increase over time.Long-term treatment with SC abatacept was associated with low incidence rates of serious infections, malignancies, and autoimmune events and was well tolerated, with infrequent injection site reactions. These findings are consistent with those related to treatment with intravenous abatacept. Long-term treatment with SC abatacept did not lead to new safety signals over time.
Abstract 4167: Prognostic Importance of Nutritional Status in Patients with Chronic Heart Failure
Authors: Nobuyuki Shiba, Tomohiro Tada, Mika Matsuki, Yutaka Kagaya, Hiroaki Shimokawa
Journal: Circulation (2006)

Background: Nutritional abnormalities are common among patients with chronic heart failure (CHF). However, little is known regarding clinical implication to evaluate the nutritional status in CHF patients. In this study, we examined the prognostic impact of nutrition-related factors, including serum albumin level (ALB), total lymphocyte count (TLC), and body mass index (BMI) in patients with CHF. Methods: We prospectively enrolled 280 stable patients with stage-C/D CHF since February 2000. Kaplan-Meier analyses and multivariate Cox regression analyses were performed to evaluate the association between the mortality and the nutrition-related factors mentioned above. Covariables used in the multivariate models were ALB, TLC, BMI, hemoglobin concentration, left ventricular ejection fraction, etiology of CHF, serum creatinine level, and age at the entry. Results: The mean age of the study population was 61.2±14.9 years and the mean follow-up period was 2.4±1.5 years. Kaplan-Meier analyses showed that the incidences of all-cause mortality were significantly higher in patients with lower ALB, lower TLC, or lower BMI as compared those without the nutritional abnormalities (Figure ). Multivariate analyses revealed that higher TLC was an independent significant predictor of freedom from cardiac-cause death (HR 0.9993, p=0.016) and higher ALB was significantly associated with increased survival (HR 0.563, p=0.03). Conclusions: The evaluation of nutritional status may be a powerful and cost-effective tool in predicting the mortality of patients with CHF. Further research is necessary to evaluate the importance of nutritional improvement in such patients.
Biomarker profiles of BALF in ALI/ARDS due to pandemic (H1N1) 2009 influenza
Authors: Toshimichi Horiuchi, Toshiki Yokoyama, Nobumitsu Kobayashi, Yosuke Wada, Hiroshi Yamamoto, Keishi Kubo
Journal: European Respiratory Journal (2011)

Background:  The outbreak of the 2009 pandemic influenza A (H1N1) virus was identified as a Pandemic. However, the clinical and epidemiologic characteristics of the novel influenza were not sufficiently elucidated.   Methods:  Patients who were hospitalized because of the novel influenza infection were enrolled in the study between August 2009 and December 2009 at Shinshu University Hospital. Furthermore, the patients with acute lung injury (ALI)/acute respiratory distress syndrome (ARDS) due to influenza A infection were collected. The patients9 condition, laboratory data, the respiratory management, and oxygenation were analyzed. Bronchoalveolar lavage (BAL) was performed on admission.   Results:  Nine patients were hospitalized and treated with anti-viral therapy such as oseltamivir. Five of 9 patients showed ALI/ARDS. Three of the 5 patients were treated with mechanical ventilation. Only one patient died in the intensive care unit because of the refractory hypoxemia due to the deterioration of a co-infection. BAL was performed in 3 patients and all of them showed alveolar hemorrhage. The IL-6, IL-8, KL-6, SP-D, thrombomodulin and HMGB-1 levels in BAL fluid were elevated higher than the serum. The serum concentration of KL-6 and SP-D were elevated on day 3 and 7 in the dead patient only.   Conclusion:  This study showed lung injury due to 2009 pandemic influenza A (H1N1) virus was formed by the direct ALI/ARDS without a cytokine storm. This suggested that the influenza virus directly injured the lung.