tbuckley/cabot-search huggingface dataset:
Emetine Toxicity with Electrocardiographic Abnormalities
Authors: LESLIE J. CERA
Journal: Circulation (1956)

Seven case histories are presented illustrating various aspects of the noxious effects of emetine on the heart. T-wave changes, S-T segment deviations, and partial heart block are demonstrated. A case of frank myocardial infarction in a young man occurring during the administration of emetine is described. Finally, both persistence and lability of emetine-induced changes are illustrated.
Prevalence of Ventricular Aneurysm in Coronary Artery Disease. An Angiographic Appraisal.
Authors: Tsung O. Cheng
Journal: Annals of Internal Medicine (1970)

Meeting Abstracts1 May 1970Prevalence of Ventricular Aneurysm in Coronary Artery Disease. An Angiographic Appraisal.Tsung O. Cheng, M.D., F.A.C.P.Tsung O. Cheng, M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-72-5-785_3 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptCineventriculography in 100 consecutive patients with coronary artery disease subjected to simultaneous coronary cine arteriography showed the presence of ventricular aneurysm in 35. All but one had either compete obstruction of one major or severe narrowing of at least two or three important vessels demonstrated by selective coronary arteriography. The presence of a ventricular aneurysm could usually be suspected during coronary arteriography by the marked sparsity, or wide separation, or both, of the arterial branches in a given site. Mural thrombus was suggested by either a filling defect or a 'mackerel-sky' pattern. Radiological cardiomegaly was not always present; plain roentgenogram... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: Tsung O. Cheng, M.D., F.A.C.P.Affiliations: Brooklyn, N.Y. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byMurmurs in Coronary-Artery Disease 1 May 1970Volume 72, Issue 5Page: 785-785KeywordsAneurysmsAngiographyCoronary arteriesStable coronary artery diseaseThrombosis ePublished: 1 December 2008 Issue Published: 1 May 1970 PDF downloadLoading ...
China and Population Control-Reply
Authors: En Ma
Journal: JAMA (1989)

<h3>In Reply. —</h3> Dr Chen is correct about one part of the phonetic translation of one child, one family.<i>Du</i>, not<i>do</i>, is correct. However, in Mainland China, we call one child, one family du<i>sheng zi nu instead of yi jia yi hai</i>. In this instance,<i>du sheng zi nu</i>does not mean only son, only daughter because in this phrase<i>zi nu</i>means "child." Dr Dykers' explanation about the formula of the quality of life is well taken. As mentioned in his letter, to increase the quality of life, China's population must be controlled because of limited resources and technical capacities. Yet, population control would be needed even if China were a developed country. Population control is not only the problem of China and other developing countries, but also that of the whole world. By July 11, 1987, the earth's 5 billionth citizen was born. At the present
The Department of Health, Education, and Welfare
Authors: Vernon E. Wilson
Journal: JAMA (1974)

This is an excellent review of the Department of Health, Education, and Welfare (HEW) from the standpoint of an experienced administrator and should be required reading for any newly appointed administrative person within HEW as well as all health resources people in the field of public service who have substantial, direct dealings with that department. While I would not have selected the same way to describe the "five social revolutions" that the author uses, nevertheless, accepting those descriptions, the narrative is lucid, persuasive, and internally consistent. Its greatest contribution lies in the analysis of the impossibility of administering a government department in the same manner that one can and should administer an industrial institution. Mr. Miles' detailed understanding of the underlying principles reveals very clearly the benefit of his many years of experience within the government. Readers should be prepared, however, to understand the bias in personal conviction that the
Preventing Injuries, Disability, and Death at Work (Starting With Vehicles and Guns!)
Authors: Gilbert S. Omenn
Journal: JAMA (1982)

In this issue ofThe Journal(p 692), Baker and colleagues report a painstaking epidemiologic investigation of all 148 fatal work-related injuries for one year in the state of Maryland. The diverse causes and circumstances are specified in detail and on a scale far more comprehensible than the National Safety Council's national estimates of 13,000 deaths and more than 200 million lost workdays per year. Surprisingly, perhaps, the leading cause of death by far was motor vehicle accidents of many kinds, and the second leading cause was assault with guns. The majority of deaths involved hazards not addressed by most professional or regulatory efforts to improve occupational safety and health. People who drive on the job, pilots, farmers, and persons at high risk of being assaulted are outside the protection of the Occupational Safety and Health Act for all practical purposes. These results in one state reflect the nationwide shift
Traumatic Rupture of the Thoracic Aorta
Authors: James W. Pate
Journal: JAMA (1968)

During a 15-month period, six patients with acute traumatic rupture of the arch of the aorta were treated. This experience demonstrated that delay in recognition and repair is disastrous and that the only long-term survivors had early surgical repair. The lesion is far more common, particularly associated with automobile accidents, than is usually recognized. Frequently, no evidence of chest injury is present, but deceleration stresses appear to be common to all cases. When both mediastinal widening on chest roentgenograms and a history of decelerating accident are present, aortography is indicated. When complete rupture of the aorta is demonstrated, emergency surgical repair should follow.
Identified cases of acute hepatitis C from computerized laboratory database: A hospital-based epidemiological and clinical study
Authors: Chao-Hung Hung, Sheng-Nan Lu, Jing-Houng Wang, Shu-Fen Hung, Chien-Hung Chen, Tsung-Hui Hu, Chuan-Mo Lee, Chi-Sin Changchien
Journal: Journal of Infection (2008)
Serum alpha-glutathione S transferase in alcoholics: inverse corelation with the severity of liver fibrosis
Authors: Albert Tran, Pierre-Yves Jeander, Eugenia Marine-Barjoan, Patrick Hastier, Nicolas Demuth, Fabrice Longo, Marie-Christine Saint-Paul, Sylvia Benzaken, Patrick Rampal
Journal: Journal of Hepatology (2002)
Scene in Print: What About Your Engine?
Authors: M. V. GUMEDE
Journal: Annals of Internal Medicine (1972)

Letters, Comments, and Corrections1 November 1972Scene in Print: What About Your Engine?M. V. GUMEDE, M.B., B.CH.M. V. GUMEDE, M.B., B.CH.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-77-5-818_3 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptModes of living have changed. Urbanization, industrialization, resettlement schemes, westernization and detribalization have all combined to break down old, traditional norms and practices that governed the brewing and consumption of alcoholic beverages. Numerous concoctions have come onto the market.Isishimeyana, imfulamfula, intoyaphansi, 'Barberton', etc., are untraditional brews which are intended to ensure big returns at the shebeens. Their alcoholic content is not known. There is also a distillategaviniwhose alcohol content is estimated at 85%. During the last war when petrol was rationed some motorists are said to have enjoyed several miles of extra driving usinggavini. The beverages... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 November 1972Volume 77, Issue 5Page: 818-818KeywordsAlcoholic beveragesAlcoholicsAlcoholsBeverages Issue Published: 1 November 1972 PDF downloadLoading ...
COMPARISON OF THREE-YEAR CLINICAL OUTCOME WITH THE CRUSH VERSUS THE CULOTTE TECHNIQUE USING SIROLIMUS-ELUTING STENT IN CORONARY BIFURCATION LESION: FROM THE J-CYPHER REGISTRY
Authors: Toshihiro Tamura, Takeshi Kimura, Takeshi Morimoto, Kazushige Kadota, Yoshihisa Nakagawa, Kazuaki Mitsudo
Journal: Journal of the American College of Cardiology (2011)
Transcriptome-wide Discovery of microRNA Binding Sites in Human Brain
Authors: Ryan L. Boudreau, Peng Jiang, Brian L. Gilmore, Ryan M. Spengler, Rebecca Tirabassi, Jay A. Nelson, Christopher A. Ross, Yi Xing, Beverly L. Davidson
Journal: Neuron (2014)

Highlights•Ago2 HITS-CLIP reveals miRNAs and their transcriptomic binding sites in human brain•>1,800 Ago2 binding sites correspond to the top 20 most abundant human brain miRNAs•Conserved human and mouse brain Ago binding sites associate with synaptic functions•Ago2 binding sites overlap disease-relevant polymorphisms that alter miRNA seed pairingSummaryThe orchestration of brain function requires complex gene regulatory networks that are modulated, in part, by microRNAs (miRNAs). These noncoding RNAs associate with argonaute (Ago) proteins in order to direct posttranscriptional gene suppression via base pairing with target transcripts. In order to better understand how miRNAs contribute to human-specialized brain processes and neurological phenotypes, identifying their targets is of paramount importance. Here, we address the latter by profiling Ago2:RNA interactions using HITS-CLIP to generate a transcriptome-wide map of miRNA binding sites in human brain. We uncovered ∼7,000 stringent Ago2 binding sites that are highly enriched for conserved sequences corresponding to abundant brain miRNAs. This interactome points to functional miRNA:target pairs across >3,000 genes and represents a valuable resource for accelerating our understanding of miRNA functions in brain. We demonstrate the utility of this map for exploring clinically relevant miRNA binding sites that may facilitate the translation of genetic studies of complex neuropsychiatric diseases into therapeutics.
What's Wrong With the ERISA Vacuum?
Authors: Lawrence O. Gostin
Journal: JAMA (1993)

THROUGHOUT the political campaigns waged during 1992, health care for Americans was one of the major issues. Candidates repeatedly expressed concern for the 30 to 65 million individuals who are not insured or who have inadequate coverage for their health care needs.<sup>1</sup>Ironically, as the fall election campaigns were concluding, the Supreme Court of the United States was deliberating on whether to hear an appeal from a decision of the Fifth Circuit Court of Appeals<sup>2</sup>that may result in more individuals being cast into the ranks of the uninsured or inadequately insured. Just a few days after Americans elected a presidential candidate committed to providing universal health care, the Supreme Court—with two justices dissenting—decided not to accept an appeal,<sup>2,3</sup>by the executor of the estate of John McGann, from the lower court judgment, which allowed an employer to reduce health care benefits radically for one of its
Effects of antibodies to myosin light chain kinase on contractility and myosin phosphorylation in chemically permeabilized smooth muscle.
Authors: P De Lanerolle, J D Strauss, R Felsen, G E Doerman, R J Paul
Journal: Circulation Research (1991)

We have used an immunological approach to investigate the role of myosin light chain phosphorylation (MLC-Pi) in the control of contractility in smooth muscle. Our aim was to specifically inhibit myosin light chain kinase (MLCK) in the presence of physiologically activating levels of Ca2+ so that other putative Ca2(+)-dependent regulatory systems could be unmasked. Fab fragments were prepared by papain digestion of immunoglobulin G (IgG) molecules obtained from goats immunized with turkey gizzard MLCK. Anti-MLCK Fab was then purified by chromatography on an MLCK-Sepharose 4B column. These affinity-purified Fab fragments inhibit the activity of MLCK purified from turkey gizzard smooth muscle and interact monospecifically with MLCK in various mammalian smooth muscles as demonstrated by a Western blot analysis. The effect of these Fab fragments on the contractile properties was tested in guinea pig taenia coli made permeable (skinned) using Triton X-100. Skinned fibers, approximately 100 microns in diameter and 4 mm long, were mounted for isometric measurements and immersed in calcium-EGTA buffers. Fibers preincubated with anti-MLCK Fab in relaxing solution (Ca2+ less than 1 nM) for 75 minutes developed about 25% of the isometric force of a parallel control contraction when transferred to contracting solution (Ca2+ = 0.5 microM). When added to contracting solution at the peak of a contracture, anti-MLCK Fab elicited a relaxation that was complete in about 120 minutes despite the presence of Ca2+. No significant effect on isometric force was observed when fibers were incubated with another affinity-purified mouse Fab raised against the Fc region of human IgG (control Fab).(ABSTRACT TRUNCATED AT 250 WORDS)
Painful Teeth and Dysglycemia
Authors: W. M. Ringsdorf
Journal: JAMA (1975)

<h3>To the Editor.—</h3> Occasional published reference has been made concerning the relationship between diabetes mellitus (hyperglycemia) and percussion-induced pain or sensitivity of the teeth. However, these are few compared to the many publications dealing with oral manifestations of diabetes. As far as could be determined, no published attention has been given to the possible association of a sensitivity to percussion in teeth and overall carbohydrate metabolism (hyperglycemia, normoglycemia, and hypoglycemia). Considering these<i>three</i>aspects of glycemia, there appears to be a distinct relationship between tooth percussion pain and dysglycemia, both hyperglycemia and hypoglycemia. In an age- and sex-paired analysis of 18 subjects, a three-hour glucose tolerance test (100 gm of glucose) was run on nine subjects with and nine subjects without percussion-sensitive teeth. Although there was no statistically significant difference in the mean glucose values of these two groups, the variances were highly significant at every temporal point-fasting, one-half hour,
Scintigraphy of an Avulsion Injury of the Sartorius Insertion in the Pelvis
Authors: CLAYTON FRATER, HANS VAN DER WALL
Journal: Clinical Nuclear Medicine (2002)

FRATER, CLAYTON B.H.S.M., A.N.M.T.; VAN DER WALL, HANS M.B.B.S., Ph.D., F.R.A.C.P. Author Information
Identification and quantitation of asbestos in talc
Authors: Arthur N. Rohl, Arthur M. Langer
Journal: Environmental Health Perspectives (1974)

The currently used analytical methods for identification, characterization and quantitation of asbestos fiber in consumer talcum products include polarized light microscopy, x-ray diffraction analysis, transmission electron microscopy with selected area electron diffraction and electron microprobe techniques. Light microscope methods have severe limitations imposed by the ultimate size resolution of the light-optical system. Small particles go unresolved; those marginally resolved may possess optical properties different from those properties cited in the literature; most optical properties, e.g., indices of refraction, are difficult to measure on small particles. In addition to these difficulties, talc fibers often possess optical properties different from those of talc plates, which further confound analysis. Light microscopy is recommended for use only as a preliminary tool on limited, large-sized, samples. Transmission electron microscopy is a good standard technique for visualization of contaminant asbestos fibers. Together with selected area electron diffraction, talc fibers may be easily differentiated from amphibole asbestos fibers on the basis of both morphological and structural characterization. Chrysotile fibers are easily distinguished on this basis as well. The amphibole asbestos minerals require chemical characterization to differentiate among the different fiber types. Probe analysis is mandatory for such fibers. The major drawbacks to electron beam instrumentation for the mineralogical characterization of talcum products are the time and effort required for data acquisition. These techniques do not lend themselves to routine study. X-ray diffraction analysis, utilizing the step-scan method, offers a relatively rapid, quantitative technique for gross fiber analysis. Based on comparison with standard specimens the fiber content of talcs may be quantitatively determined. It is essential to employ a specimen preparation technique which yields homogeneously dispersed particles. Tremolite may be determined at levels as low as 0.10% by weight, chrysotile 0.25%, and anthophyllite at 2.0% by weight occurrence in talc. The variance of these values depends upon many factors, including the mass absorption coefficient of the fiber types as compared to talc and selected diagnostic reflections and their relative intensities. Each of the above techniques is described in detail. A method for routine analysis of consumer talcum products is suggested.
CD24hiCD27+ and plasmablast-like regulatory B cells in human chronic graft-versus-host disease
Authors: Adèle de Masson, Jean-David Bouaziz, Hélène Le Buanec, Marie Robin, Alix O’Meara, Nathalie Parquet, Michel Rybojad, Estelle Hau, Jean-Benoît Monfort, Mylène Branchtein, David Michonneau, Valérie Dessirier, Flore Sicre de Fontbrune, Anne Bergeron, Raphaël Itzykson, Nathalie Dhédin, Djaouida Bengoufa, Régis Peffault de Latour, Aliénor Xhaard, Martine Bagot, Armand Bensussan, Gérard Socié
Journal: Blood (2015)
Altered C-Fiber Function as an Indicator of Early Peripheral Neuropathy in Individuals With Impaired Glucose Tolerance
Authors: Alistair Q. Green, Singhan Krishnan, Francis M. Finucane, Gerry Rayman
Journal: Diabetes Care (2009)

OBJECTIVE This study explored the importance of glycemic burden compared with features of the metabolic syndrome in the pathogenesis of diabetic neuropathy by comparing C-fiber function in people with type 1 diabetes to that in people with impaired glucose tolerance (IGT). RESEARCH DESIGN AND METHODS The axon reflex–elicited flare areas (LDIflares) were measured with a laser Doppler imager (LDI) in age-, height-, and BMI-matched groups with IGT (n = 14) and type 1 diabetes (n = 16) and in healthy control subjects (n = 16). RESULTS The flare area was reduced in the IGT group compared with the control (2.78 ± 1.1 vs. 5.23 ± 1.7 cm2, P = 0.0001) and type 1 diabetic (5.16 ± 2.3 cm2, P = 0.002) groups, whereas the flare area was similar in the type 1 diabetic and control groups. CONCLUSIONS This technique suggests that small-fiber neuropathy is a feature of IGT. The absence of similar small-fiber neuropathy in those with longstanding type 1 diabetes suggests that glycemia may not be the major determinant of small-fiber neuropathy in IGT.
CARCINOMA OF THE CECUM: WHAT ARE THE CHANCES FOR CURE?
Authors: CLAUDE F. DIXON
Journal: JAMA (1934)

The question to which I wished to find an answer was whether a patient who has remained well for at least five years following resection of a segment of the colon because of carcinoma may be classified as cured. Considerable doubt may rightly exist as to whether or not this question is answerable. Some persons apparently are inherently susceptible to the development of malignant processes. Examples are the multiple carcinomas, each of a distinctly different type, occurring simultaneously or consecutively in the same patient. Malignant lesions of the colon, for the most part, are single (except those which apparently arise from malignant degeneration accompanying multiple polyposis). Radical removal is the most effective means of relief, and while the ultimate outcome in many cases is disastrous, encouragement in the surgical treatment of carcinoma of the large intestine is spurred on by those persons who, once victims of the disease, have remained
Bath vs. oral psoralen plus ultraviolet A: is one more effective than the other?
Authors: P. Wolf
Journal: British Journal of Dermatology (2013)

ORIGINAL ARTICLE, p 704 Although psoralen plus ultraviolet A (PUVA) was introduced more than 30 years ago as a highly effective treatment of psoriasis,1 2 there is a paucity of controlled studies. Indeed, it was not until recently that the efficacy of PUVA was confirmed in a placebo‐controlled study using the PASI 75 (75% or more improvement of Psoriasis Area and Severity Index) reduction rate as a new standard enabling better comparison with other antipsoriatic treatments. Berneburg et al.3 have now compared, in a randomized, multi‐centre study of five institutions, bath vs. oral PUVA and found equal efficacy. Both treatments significantly reduced the PASI as determined by an intention‐to‐treat analysis in the 74 patients enrolled. Within 6 weeks of treatment bath PUVA reduced the median PASI by 74% whereas oral PUVA diminished it by 62% (P = 0·389). These results are consistent with other recent reports on PUVA in psoriasis revealing PASI 75 in 60% and 69% of the patients, using nonresponder imputation4 or a modified worst‐case scenario analysis.5
Cardiovascular disease in the tropics. I. Rheumatic heart.
Authors: A G Shaper
Journal: BMJ (1972)

Throughout the "Suggestions for Consideration by the Council of the Royal College of Physicians of London," written by Dr. Gavin Milroy almost 100 years ago, runs a considerable concern with public health in the tropical countries then under British administration."I would express my strong desire that more diligent and continued attention may be paid than has yet been attempted in this country to the study of the accurate geography of disease ... which is often essential to the complete determina- tion of their true natural history."He respectfully left it to the council of the college to determine "whether it would be ad- visable to invite from time to time the co-operation of medical men from foreign lands ... able and willing to deliver their lectures in the English language," . . .and I am grateful to the council for having so determined.In these lectures I will present material on rheumatic heart disease and endomyocardial fibrosis, on blood pressure and hypertension, and on coronary heart disease.I make no apology for not discussing Chagas's disease of the heart, idiopathic arteritis, ventricular aneurysms, electrocardiographic abnor- malities, or any of the other fascinating problems peculiar to the tropics.I am concerned to show that the differences in natural history made evident from tropical experience give a per- spective on disease in our own community that we cannot pos- sibly obtain from studies limited to our own environment.This is the message of these lectures, which are concerned with public health and the prevention of cardiovascular disease both in the tropics and in the temperate regions.The word "tropical" calls to mind sleeping sickness, schisto- somiasis, and other diseases directly related to the environment.It also suggests exotic flora and fauna and unusual communities.