tbuckley/cabot-search huggingface dataset:
Prevalence and characteristics of meticillin-resistant Staphylococcus aureus in humans in contact with farm animals, in livestock, and in food of animal origin, Switzerland, 2009
Authors: H Huber, S Koller, N Giezendanner, R Stephan, C Zweifel
Journal: Eurosurveillance (2010)

A total of 2,662 samples, collected from March to September 2009 in Switzerland, were tested for the presence of meticillin-resistant Staphylococcus aureus (MRSA). The collection comprised nasal swabs from 148 pig farmers, 133 veterinarians, 179 slaughterhouse employees, 800 pigs, 300 calves, 400 cattle, 100 pooled neck skin swabs from chicken carcasses, and 460 food samples of animal origin. Moreover, 142 S. aureus strains, isolated from bovine mastitis milk, were included in the study. Twenty samples (&lt;1%; four veterinarians, 10 pigs, three calves, one young bull, and two mastitis milk samples) tested positive for MRSA. Genotyping of the MRSA strains was performed by multilocus sequence typing, spa- and SCCmec-typing, and revealed ST398 (n=18), ST8 (n=1), ST 1 (n=1), spa types t011 (n=7), t034 (n=11), t064 (n=1), t127 (n=1), and SCCmec types IV (n=4) and V (n=16). The 20 MRSA strains were subjected to antibiotic susceptibility testing and pulsed-field gel electrophoresis using the restriction enzyme EagI. Supplementary PCR reactions were performed to investigate the presence of Panton-Valentine leukocidin and staphylococcal enterotoxins A to D.
Distal spleno-renal shunt versus endoscopic sclerotherapy in the prevention of variceal rebleeding
Authors: Gian Paolo Spina, J. Michael Henderson, Layton F. Rikkers, Josep Teres, Andrew K. Burroughs, Harold O. Conn, Luigi Pagliaro, Roberto Santambrogio, Antonio Ascione, Josep M. Bordas, W. Scott Brooks, Kenneth M. Buchi, David A. Burnett, Robert A. Cormier, John T. Galambos, Michael H. Kutner, William J. Millikan, Enrico Opocher, Andrea Pisani, Stanley P. Riepe, Josep Visa, W. Dean Warren
Journal: Journal of Hepatology (1992)
Abstract P2-13-14: Does therapeutic mammoplasty reduce mastectomy rates?
Authors: Jennifer Pollard, Pang Wong, James Mansell, Juliette Murray, Alison Lannigan, Julie Doughty, Laszlo Romics, Sheila Stallard, Christopher Wilson
Journal: Cancer Research (2015)

Abstract Introduction: Therapeutic mammoplasty (TM) is increasing in popularity as a method for enhancing breast conserving surgery. Studies have shown it’s oncologically safe, whilst improving cosmetic outcome1,2,3. Therapeutic mammoplasty has been gaining popularity in West of Scotland over the past five years. Initially it was thought this may reduce requirement for mastectomy and immediate reconstruction. We have recorded type of surgery patients would have required had they not been suitable for TM, looking at changing demographic of surgical workload. Methods: Prospective data collected about patients undergoing TM in West of Scotland since 2011 in Victoria Infirmary, Western Infirmary and in NHS Lanarkshire. We reviewed clinical indications for TM, surgical alternative, Body Mass Index (BMI) and smoker status. Results: Seventy-nine patients were identified. In 67 cases, alternative surgical option of mastectomy or standard conservation was recorded. Mean BMI was 29. 41% of patients had contralateral surgery for symmetry at the same time. In 28 cases (35%) TM avoided need for mastectomy. In 39 cases (49%) it was felt that cosmetic result would be improved by TM compared with standard conservation. During the study period, rates of mastectomy with immediate reconstruction as a proportion of total number of treated cancers have remained similar. Conclusions: Whilst introduction of therapeutic mammoplasty in our region has improved options offered to patients and likely cosmetic outcomes, it has not had a major impact in reducing mastectomy rates or demand for immediate reconstruction. It has probably increased surgical workload of plastic surgeons as these cases are often performed as joint procedures. References: 1. Iwuchukwu OC, Harvey JR, Dordea M, Critchley AC, Drew PJ. The role of oncoplastic therapeutic mammoplasty in breast cancer surgery – A review. Surgical Oncology. 2012;21:133-141 2. McCulley SJ, Macmillan RD. Planning and use of therapeutic mammoplasty – Nottingham approach. British Journal of Plastic Surgery. 2005;58:889-901 3. Clough K, Lewis J, Couturand B, Fitoussi A, Nos C, Falcou M. Oncoplastic techniques allow extensive resections for breast-conserving therapy of breast carcinomas. Annals of Surgery. 2003;237(1):26-34. Citation Format: Jennifer Pollard, Pang Wong, James Mansell, Juliette Murray, Alison Lannigan, Julie Doughty, Laszlo Romics, Sheila Stallard, Christopher Wilson. Does therapeutic mammoplasty reduce mastectomy rates? [abstract]. In: Proceedings of the Thirty-Seventh Annual CTRC-AACR San Antonio Breast Cancer Symposium: 2014 Dec 9-13; San Antonio, TX. Philadelphia (PA): AACR; Cancer Res 2015;75(9 Suppl):Abstract nr P2-13-14.
Portrait of Thomas Bulwer
Authors: M Therese Southgate
Journal: JAMA (2006)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The role of HIWI in stem cell maintenance and sarcomagenesis.
Authors: S. Siddiqi, M. Terry, I. Matushansky
Journal: Journal of Clinical Oncology (2011)

e20500 Background: PIWI proteins comprise a highly conserved protein family that promote genomic integrity during early development via small RNA-mediated gene silencing and DNA methylation-mediated inhibition of transposon migration. Surprisingly, the human ortholog of Piwi - HIWI, is highly expressed at the mRNA level in soft tissue sarcomas (and other cancers) and is associated with poor clinical outcomes. However, the reason that high Hiwi levels would be associated with cancer promotion rather than genomic stability remains unknown. Methods: We have employed immunohistochemistry, PCR and western blotting techniques. Results: Our studies reveal that Hiwi expression inversely correlates with tumor grade/differentiation (i.e., expressed universally in poorly differentiated, high grade sarcomas). Exogenous over-expression of HIWI in mesenchymal stem cells (MSCs) prevents their in vitro maturation and transforms MSCs into undifferentiated sarcomas in a xenograft model. Functionally, over-expression of Hiwi in MSCs lowers transposon expression levels, increases global DNA methylation levels, and results in promoter hypermethylation and gene dowregulation of many tumor suppressor genes; all of which is reversible via treatment with DNA demethylating agents. Finally, inducible downregulation of endogenous Hiwi in a Hiwi-expressing undifferentiated sarcoma cell line inhibits its growth. Conclusions: These studies identify a novel oncogenic role for Hiwi and support a model in which HIWI mediates tumorigenesis via global silencing of multiple tumor suppressors through DNA methylation of their promoter regions. These studies also provide a rationale for the use of epigenetic agents in Hiwi-expressing cancers.
Abstract 16743: Sauna Bathing, Sudden Cardiac Death and Cause-Specific Cardiovascular Mortality
Authors: Tanjaniina Laukkanen, Hassan Khan, Francesco Zaccardi, Jari A Laukkanen
Journal: Circulation (2014)

Introduction: Warm sauna bathing is associated with a better hemodynamic function; however, the association of sauna bathing with fatal cardiovascular outcomes is not known Hypothesis: The frequency and duration of sauna bathing may be related to the risk of sudden cardiac death (SCD), fatal coronary heart disease (CHD) and cardiovascular disease (CVD) events. Methods: This study is based on 2323 (42 to 60 years) participants from the Kuopio Ischemic Heart Disease risk factor study, which is a population-based sample of men from Eastern Finland. During median follow-up of 20.7 years (interquartile range 18.1-22.6 years), a total of 197 SCDs, 282 fatal CHD and 407 CVD events occurred. Results: Frequency, duration, and temperature of sauna bathing were assessed at baseline; 1060 participants reported using sauna once weekly, 1054; 2-3 times per week and 201; 4-7 per week, respectively. After adjustment for conventional CVD risk factors, compared to men reporting 1 sauna per week the hazard ratio (HR) of SCD was 0.87 (95% confidence interval, CI 0.64 to 1.18) for 2-3 sauna/week and 0.46 (95% CI 0.23 to 0.89) for 4-7 sauna/week (p=0.036 for linear trend). Compared to men using sauna 19 minutes per session (highest third) (p=0.002 for linear trend). Similar results were found for the associations between frequency or duration of sauna bathing with fatal CHD or CVD events. Conclusions: The frequency and duration of sauna are associated with a substantial reduced risk of SCD, CHD and CVD mortality. Further studies are warranted to define the potential mechanism behind these associations.
Risks and Benefits of Severe Caloric Restriction
Authors: Jun James Mao
Journal: JAMA (2004)

Georg Schett, MD georg_schett@yahoo.com Kurt Redlich, MD Peter Pietschmann, MD Josef Smolen, MD University of Vienna Vienna, Austria Stefan Kiechl, MD Johann Willeit, MD Innsbruck University Clinic Innsbruck, Austria Friedrich Oberhollenzer, MD Siegfried Weger, MD Georg Egger, MD Agnes Mayr, MD Josef Jocher, MD Bruneck Hospital Bruneck, Italy Qingbo Xu, MD St George’s Hospital Medical School London, England Steven Teitelbaum, MD Washington University School of Medicine St Louis, Mo
The 30‐day metric in acute heart failure revisited: data from <scp>IN‐HF</scp> Outcome, an Italian nationwide cardiology registry
Authors: Giuseppe Di Tano, Renata De Maria, Lucio Gonzini, Nadia Aspromonte, Andrea Di Lenarda, Mauro Feola, Marco Marini, Massimo Milli, Gianfranco Misuraca, Andrea Mortara, Fabrizio Oliva, Giovanni Pulignano, Giulia Russo, Michele Senni, Luigi Tavazzi
Journal: European Journal of Heart Failure (2015)
Pulmonary rehabilitation: Are the effects similar in populations from different countries?
Authors: Carlos Augusto Camillo, Chris Burtin, Daniel Langer, Vinicius Cavalheri, Nidia Aparecida Hernandes, Ercy Mara Cipulo Ramos, Vanessa Probst, Fabio Pitta, Rik Gosselink, Thierry Troosters
Journal: European Respiratory Journal (2011)

Background: There are no studies investigating whether differences in socioeconomic, ethnic or climate characteristics could interfere with outcomes of pulmonary rehabilitation (PR) programs.

Objective: To compare the training effects of similar exercise training programs applied to two groups of patients with chronic obstructive pulmonary disease (COPD) living in different world regions: one from Western Europe (Belgium) and another from South America (Brazil).

Methods: 564 patients with moderate to severe COPD (45 in Brazil and 519 in Belgium) underwent similar high-intensity outpatient PR programs. Baseline values and their respective post-training changes of pulmonary function, exercise capacity, physical activities in daily life, respiratory muscle force, health-related quality of life (HRQoL) and functional status were compared between centers.

Results: Patients were matched for age, BMI and FEV1. Baseline differences were found in the 6-minute walking test (67±12%pred in Brazil vs 57±20%pred in Belgium; p<0,01), expiratory muscle force (96±28cmH2O in Brazil vs 143±48cmH2O in Belgium; p<0,01) and functional status (all domains had better scores in Brazil in the Modified Pulmonary Functional Status and Dyspnea questionnaire; p<0,01). After 3 months of training, only the dyspnea domain of the Chronic Respiratory Disease questionnaire showed significant difference between centers (0,50 [-2 – 5] in Brazil vs 5 [2 – 8] in Belgium; p<0,01).

Conclusions: Similar PR programs applied in populations from different countries yield similar improvements in exercise capacity, respiratory muscle function, functional status and most HRQoL outcomes. Dyspnea was more enhanced in Belgian patients.
Children Who Run on All Fours and Other Animal-Like Behaviors in the Human Child.
Authors: Aleš Hrdlička
Journal: JAMA (1931)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Laser in situ keratomileusis intraoperative complications using one type of microkeratome11No author has any type of financial interest that is related to this article, including stock or ownership of a business entity connected to a product described in this article, paid consulting for the company or competing companies, or patent rights to a drug or piece of equipment. Authors or their family do not own or have potential rights to more than 1% of the company or competing company and have no …
Authors: Ioannis G Pallikaris, Vikentia J Katsanevaki, Sophia I Panagopoulou
Journal: Ophthalmology (2002)
ARTIFICIAL PNEUMOTHORAX THERAPY
Authors: Wm. C. Pollock
Journal: Annals of Internal Medicine (1935)

Article1 April 1935ARTIFICIAL PNEUMOTHORAX THERAPYWM. C. POLLOCK, M.D., F.A.C.P.WM. C. POLLOCK, M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-8-10-1302 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe most extensively used and the most successful procedure of compression therapy in the treatment of pulmonary tuberculosis is artificial pneumothorax. Other procedures of compression or collapse therapy should be used when pneumothorax is impossible, unsuccessful, or when indicated as an adjunct to the compression and relaxation obtained by pneumothorax induction.When the tuberculous involvement is apparently limited to one lung and is of a character considered of sufficient clinical significance, unilateral pneumothorax is indicated. When this character of involvement exists in both lungs, bilateral pneumothorax is indicated.In treating a large group of cases by this type of therapy,... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Denver, Colorado*Published by permission of The Surgeon General, U. S. Army.Read before the Rocky Mountain Tuberculosis Conference, Colorado Springs, September 18 to 19, 1934.From the Medical Service, Fitzsimons General Hospital. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 April 1935Volume 8, Issue 10Page: 1302-1308KeywordsLungsMedical servicesSurgeons ePublished: 1 December 2008 Issue Published: 1 April 1935 PDF downloadLoading ...
Transactions of the American Surgical Association.
Authors: H. E. Clutterbuck
Journal: JAMA (1893)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
154. Relationship between the Expression of Membrane Receptors (CAR, Integrin αvβ3 and Integrin αvβ5 ) and Adenoviral Transduction Efficiency
Authors: Hiroyuki Inoue, Terumasa Hisano, Yukoh Nakazaki, Gaku Sakaguchi, Ryo Kurita, Koichi Takayama, Yoichi Nakanishi, Kenzaburo Tani
Journal: Molecular Therapy (2005)

Recent reports demonstrated that GM-CSF (Granulocyte Macrophage colony-Stimulating Factor)-transduced tumor vaccines (GVAX) had substantial antitumor activity in preclinical cancer models and partially in clinical situations because of their chemotactical attraction and activation of dendritic cells. To produce GVAX efficiently, recombinant type 5 E1 deleted adenovirus encoding human GM-CSF is one of the most promising vectors (AdenoGVAX). Adenoviral gene transduction is currently considered to be mediated by CAR (Coxsackie-Adenovirus Receptor), integrin|[alpha]|v|[beta]|3 and integrin|[alpha]|v|[beta]|5. Although previous reports showed that CAR and the integrin groups could alternatively be used for adenoviral transduction in limited cells, systematical data focusing on the relationship between the expression of membrane receptors (CAR, integrin |[alpha]|v|[beta]|3 and integrin |[alpha]|v|[beta]|5) and adenoviral transduction efficiency has not been reported. As high GM-CSF production is considered to be required to obtain clinical effects, prediction of GM-CSF production from AdenoGVAX transduced tumor cells is critical to perform the clinical trial efficiently. In this study, we reported the relationship between the expression of membrane receptors and adenoviral mediated GM-CSF production rate in renal cell carcinoma (RCC) cells and non small lung carcinoma (NSCLC) cells.
Coordinate regulation of residual bone marrow function by paracrine trafficking of AML exosomes
Authors: J Huan, N I Hornick, N A Goloviznina, A N Kamimae- Lanning, L L David, P A Wilmarth, T Mori, J R Chevillet, A Narla, C T Roberts, M M Loriaux, B H Chang, P Kurre
Journal: Leukemia (2015)
Subacute Bacterial Endocarditis Following the Extraction of Teeth: Report of a Case
Authors: Mitchell Bernstein
Journal: Annals of Internal Medicine (1932)

Article1 March 1932Subacute Bacterial Endocarditis Following the Extraction of Teeth: Report of a CaseMITCHELL BERNSTEIN, M.D., F.A.C.P.MITCHELL BERNSTEIN, M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-5-9-1138 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptSubacute bacterial endocarditis may be overlooked, or it may be masked as another disease, as in the case to be reported, for some weeks, before the true nature of the disease is recognized. Moreover, the importance of being mindful of this disease in every case of illness associated with continued fever, cannot be over emphasized.Jules B., aged 25, a law student, complained on January 15, 1931, of having a slight fever every afternoon, night sweats of moderate severity and weakness.His family history was essentially negative. During childhood he had measles, mumps, diphtheria and chorea. In addition, he had... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Philadelphia, Pa.*From the service of Dr. Thomas McCrae, Jefferson Medical College Hospital, Philadelphia, Pa.†Submitted for publication, July 1, 1931. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byOral Disease Burden in Patients Undergoing Prosthetic Heart Valve ImplantationPrevention of Infective EndocarditisChanging methods of preventing infective endocarditis following dental procedures: 1943 to 1993The Use of Antibiotics for the Prevention of Bacteremia Following Oral SurgeryBacteremias of dental origin. II. A study of the factors influencing occurrence and detectionEffect of penicillin on the bacteremia following dental extractionDental Surgery as a Prophylactic in Subacute Bacterial EndocarditisSubacute bacterial endocarditis and dental proceduresThe effects of oral surgery on the course of patients with diseases of the heartProphylactic Use of Sulfapyridine in Patients Susceptible to Subacute Bacterial Endocarditis following Dental Surgical ProceduresSubacute Bacterial Endocarditis and Dental ExtractionThe pathogenesis of bacterial endocarditisStreptococcus Viridans: Bacteriemia Following Extraction of the TeethThe Dentist and Modern Concepts of Heart DiseaseRelationship Between Dental and Cardiovascular DiseaseSystemic Conditions Associated with Oral Focal Infections***Read before Section on Oral Surgery, Exodontia and Anesthesia, at the Seventy-Fourth Annual Session of the American Dental Association, Buffalo, N. Y., Sept. 14, 1932. 1 March 1932Volume 5, Issue 9Page: 1138-1144KeywordsBacterial diseasesDiphtheriaEndocarditisFeversMeaslesMumpsSweat Issue Published: 1 March 1932 PDF downloadLoading ...