tbuckley/cabot-search huggingface dataset:
The clinical outcomes and efficacy of a nurse practitioner led colonoscopy surveillance service
Authors: U. Duffy, N. Haslam, S. Sarkar
Journal: Gut (2011)

<h3>Introduction</h3> Colonoscopy surveillance has always provided service challenges with regards to appropriateness, validation, waiting times and listing for most endoscopy departments in the UK. However, following the NPSA safety alert (NPSA/2009/RRR012) for bowel cleansing agents, the service was required to be more diligent in the assessment of surveillance patients who require interval colonoscopies according to the BSG guidance for surveillance, (Revised guidelines May 2010). In order to overcome the above issues, we introduced a new Nurse Practitioner led Colonoscopy Surveillance Service. <h3>Aim</h3> To determine the clinical outcomes and efficacy of this new service. <h3>Methods</h3> Over a 4 month period, all patients due to attend for surveillance colonoscopy referrals were reviewed by a Nurse Practitioner. Estimated -GFR was checked in the at risk patients prior to the nurse led clinic (telephone or normal) before their scheduled colonoscopy. Only following their review were the patients listed. The outcomes were documented on an Access Database and audited. <h3>Results</h3> 210 patients were reviewed of which 12 patients (6%) had deceased at the time of their recall. Of the remaining 198, the median age was 68 years, &amp; ASA score 2. In the patients with eGFR recorded (n=158), 13% had a low eGFR (&lt;60). In total 12% diabetic, 6% on anticoagulants/clopidogrel, 1.5% had advanced liver disease, 1.5% with implantable cardiac devices and 1.5% required special consent or was on oral iron. In total medical management was influenced by the consultation in 32% of cases. Overall 37% of patients did not require their scheduled colonoscopy as they were either deceased or discharged back to either their referring consultant or GP. With the current colonoscopy traffic, the PCT savings surmounted to £37 128. Of those listed, 25% required the procedure at a later date and in only 42% of cases were there agreement with the initial listings. <h3>Conclusion</h3> The Nurse practitioner led clinic help achieve 100% NPSA guidance compliance. It has been invaluable in medical management of patients prior to colonoscopy thus improving patient safety and quality of care. With 37% of patients not requiring their procedure and patients surveillance interval prolonged in ¼, this offers substantial (1) savings to the PCT of potentially over £110 000 per annum and (2) improvement in colonoscopy capacity.
A platelet alpha granule membrane protein that is associated with the plasma membrane after activation. Characterization and subcellular localization of platelet activation-dependent granule-external membrane protein.
Authors: C L Berman, E L Yeo, J D Wencel-Drake, B C Furie, M H Ginsberg, B Furie
Journal: Journal of Clinical Investigation (1986)

We have identified and purified a platelet integral membrane protein (140,000 mol wt), using the KC4 monoclonal antibody specific for activated platelets, that is internal in resting platelets but exposed on activated platelets (Hsu-Lin S.-C., C.L. Berman, B.C. Furie, D. August, and B. Furie, 1984, J. Biol. Chem. 259: 9121-9126.). The expression of the protein on the platelet surface is secretion-dependent. This protein has been named platelet activation-dependent granule-external membrane (PADGEM) protein. PADGEM protein is distinct from the surface glycoproteins of resting platelets, but identical to the S12 antigen, GMP-140. Using immunofluorescent staining, resting platelets failed to stain for PADGEM protein with the KC4 antibody, but after permeabilization showed a punctate staining of the cell interior. Thrombin-stimulated intact platelets stained with a peripheral rim pattern thus demonstrating the translocation of PADGEM protein from an internal location to the cell surface. PADGEM protein expression on the platelet surface at varying thrombin concentrations correlated with alpha granule release, as measured by the secretion of platelet factor 4. Further evidence for an alpha granule localization of PADGEM protein was provided by nitrogen cavitation of resting platelets followed by metrizamide density gradient centrifugation; PADGEM protein codistributed with platelet factor 4. Using immunoelectron microscopy, the protein was localized to the alpha granule in frozen ultrathin sections of resting platelets labeled using rabbit anti-PADGEM protein antibodies, whereas in thrombin-activated platelets, the plasma membrane was labeled. These studies indicate that PADGEM protein is a component of the alpha granule membrane of resting platelets and is incorporated into the plasma membrane upon activation and secretion.
986 INSULIN RESISTANCE MAY BETTER IDENTIFY FIBROSIS IN NON-ALCOHOLIC FATTY LIVER DISEASE (NAFLD) THAN SERUM ADIPOCYTOKINES
Authors: A. Chwist, M. Hartleb, T. Kacperek-Hartleb, M. Kajor, M. Kukla, K. wirska-Korczala
Journal: Journal of Hepatology (2009)
Government sets up new service to tackle long term sickness absence
Authors: I. Torjesen
Journal: BMJ (2013)

The government is setting up an independent assessment and advisory service to help move people off long term sickness benefits and back to work.

The occupational health advice service will provide employers and GPs with access to independent occupational health advice and will offer help to employees who have been signed off as sick to get back into work. GPs will be able to refer a patient to the service at any time, and employers will be able to refer a staff member who has been on sick leave for at least four weeks. …
In vitro allergic bronchoconstriction in the brown Norway rat.
Authors: R J Dandurand, C G Wang, S Laberge, J G Martin, D H Eidelman
Journal: American Journal of Respiratory and Critical Care Medicine (1994)

The ovalbumin (OA)-sensitized Brown Norway rat (BN) demonstrates early-response (ER) and late-response (LR) allergic bronchoconstriction. To determine whether these responses could be replicated in vitro, we studied lung explants from 8-wk-old male BN rats (wt: 239 +/- 28 g), of which 19 were sensitized to OA (test) and 16 served as controls. Two weeks after sensitization, the animals' lungs were removed, filled with a 1% (wt/vol) agarose-containing solution at 37 degrees C, and cooled to 4 degrees C. Transverse slices (0.5 to 1.0 mm thick) were cut and cultured overnight. Airways were visualized with an inverted microscope and baseline images were obtained with a video camera. To study the ER, 40 airways from 15 test rats and 29 airways from 10 control rats were challenged with 2 micrograms OA and imaged each minute for 10 min. To study the LR, 40 airways from 12 test rats and 44 airways from 12 control rats were challenged with 2 micrograms OA and imaged each hour for 8 h. The maximal response (MR) for each airway was defined as the percent of airway closure. The ER and LR were both defined as an MR > or = mean + 2 SD of the controls. An ER occurred in 38 of 40 test and 2 of 29 control airways (mean MR: 42 +/- 24% versus 4 +/- 3%, p < 0.001), and was completely blocked by methysergide pretreatment in 13 airways.(ABSTRACT TRUNCATED AT 250 WORDS)
The Antihistaminic Drugs in the Treatment of the Common Cold
Authors: Francis C. Lowell, Irving W. Schiller, John E. Alman, Clifton F. Mountain
Journal: New England Journal of Medicine (1951)

A NUMBER of attempts have been made to determine whether various members of the antihistaminic group of drugs are effective in the treatment of the common cold. Among the studies reported to date, some appear to have demonstrated a beneficial or curative influence of one or more of these drugs in the common cold,1 2 3 4 5 6 whereas others have failed to present any evidence that these drugs exert a favorable effect.7 8 9 Until conclusive evidence is brought to bear on this problem, further attempts to determine the effect of the antihistaminic drugs on the common cold appear necessary.The problem is beset by . . .
Measurement of IgG4 in bile: a new approach for the diagnosis of IgG4-associated cholangiopathy
Authors: K. Vosskuhl, A. Negm, T. Framke, T. Weismüller, M. Manns, H. Wedemeyer, R. Plentz, J. Wedemeyer, T. Lankisch
Journal: Endoscopy (2011)

<b>Background and study aims:</b> Immunoglobulin G4 (IgG4)-associated cholangitis (IAC) is difficult to diagnose because on cholangiography the associated biliary tract strictures cannot be differentiated from cholangiocarcinoma or primary sclerosing cholangitis (PSC). Serum IgG4 levels show a low sensitivity and specificity and are unreliable, particularly in patients with related diseases such as PSC. As IAC takes place at the biliary epithelium, we hypothesized that IgG4 measurement in bile may have higher sensitivity compared with serum. <b>Methods:</b> Bile and serum samples were collected during cholangiography in 67 patients, including 23 patients with PSC, 25 with cholangiocarcinoma, 14 with choledocholithiasis, and five with IAC. IgG4 was measured in both bile and serum. <b>Results:</b> Bile IgG4 levels were markedly elevated in patients with IAC compared with patients with other biliary disorders. Whereas elevated serum IgG4 levels were found both in patients with PSC and IAC, biliary IgG4 levels were only increased in patients with IAC. <b>Conclusions:</b> The study demonstrates that bile IgG4 measurement is possible and may help to distinguish IAC from other diseases.
Neuroprotection reduces the risk of peri-procedural major strokes and death in octogenarians
Authors: Christina Brennan, Gary S. Roubin, Sriram S. Iyer, Sara Mgaieth, Pallavi Kumar, Nadim Al-Mubarak, Roxana Mehran, George Dangas, Martin B. Leon, Jiri J. Vitek, Gishel New
Journal: Journal of the American College of Cardiology (2002)
Hypersensitivity pneumonitis due to an ultrasonic humidifier
Authors: J. A. Alvarez‐Fernández, S. Quirce, J. L. Calleja, M. Cuevas, E. Losada
Journal: Allergy (1998)

We describe a woman with hypersensitivity pneumonitis that was related to using a home ultrasonic humidifier. A micronodular infiltrate was seen in her chest radiograph. The inhalation challenge test was performed with the humidifier, and she exhibited a positive response. The cultures of the humidifier water grew Candida albicans, Rhodotorula spp., and Aspergillus spp. The test for precipitating antibodies against the humidifier water gave a positive response, and specific IgG, IgM, and IgA antibodies against extracts of A. fumigattis, C. albicans, and Rhodotorula spp. were demonstrated in the patient's serum by ELISA. A strong, dose‐dependent inhibition of Rhodotorula IgG‐ELISA by humidifier water was observed, suggesting that Rhodotorula might be the cause of hypersensitivity pneumonitis in this patient.
Helicobacter pylori does not play a part in the dyspeptic complaints of rheumatology patients receiving long term treatment with non-steroidal anti-inflammatory drugs
Authors: X Calvet
Journal: Annals of the Rheumatic Diseases (2002)

The presence of dyspeptic symptoms is a common finding in patients treated with non-steroidal anti-inflammatory drugs (NSAIDs). Some studies seem to support the involvement of Helicobacter pylori infection in the dyspeptic symptoms reported by these patients, and suggest that eradication may be useful.To determine the variables related to dyspepsia in rheumatology patients requiring NSAID treatment, assessing in particular the role of Helicobacter pylori infection.One hundred and eighty six consecutive patients with a rheumatological disorder requiring NSAID treatment (68 male, 118 female; mean (SD) age 55 (15) years) were included in a cross sectional study; dyspeptic symptoms were measured by a previously validated scale. Helicobacter pylori infection was determined by serology. Variables related to the severity of symptoms and the need for antisecretory drugs were determined by multivariate analysis.No relation was found between Helicobacter pylori infection and dyspepsia or any of its surrogate markers (antisecretory drug use or NSAID intolerance). Female sex and treatment with antisecretory drugs were found to be independent predictors for the appearance and severity of dyspeptic symptoms. The only independent predictive variables of the requirement for antisecretory drugs were age, previous ulcer disease, taking NSAIDs with a medium or high anti-inflammatory potential, and the symptoms score.Helicobacter pylori infection does not seem to play any part in the gastric symptoms of patients treated long term with NSAIDs.
Scorecard Medicine—Measuring Process and Outcome
Authors: Robert H. Brook
Journal: Annals of Internal Medicine (1994)

Letters1 June 1994Scorecard Medicine—Measuring Process and OutcomeRobert H. Brook, MD, ScDRobert H. Brook, MD, ScDUniversity of California, Los Angeles, Center for the Health Sciences; Los Angeles, CA 90024Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-120-11-199406010-00019 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail IN RESPONSE:I agree with Dr. Clement that, unless publicly released data on quality are accurate, untoward events may occur. In particular, physicians who perceive that outcome-based systems do not adequately adjust for sickness at the time of treatment may stop caring for sick patients to improve their performance profiles. One solution is to build severity adjustment models that “overadjust” for sickness (that is, give physicians who care for sicker patients extra credit in terms of expected mortality).Patients' habits that affect outcome, such as smoking [1], weight [2], and even exercise, can be measured and included as adjustors in ...References1. Stewart AL, Brook RH, Kane RL. Conceptualization and Measurement of Health Habits for Adults in the Health Insurance Study. Vol. I, Smoking. Santa Monica, CA: RAND; 1979. R-2374/1-HEW. Google Scholar2. Stewart AL, Brook RH, Kane RL. Conceptualization and Measurement of Health Habits for Adults in the Health Insurance Study. Vol. II, Overweight. Santa Monica, CA: RAND; 1980. R-2374/2-HEW. Google Scholar3. Murata PJ, McGlynn EA, Siu AL, et al. Quality measures for prenatal care. A comparison of care in six health plans. Arch Fam Med. 1994; 3:41-9. Google Scholar4. Bernstein SJ, McGlynn EA, Siu AL, Roth CP, Sherwood MJ, Keesey JW, et al. The appropriateness of hysterectomy. A comparison of care in seven health plans. Health Maintenance Organization of Quality of Care Consortium. JAMA. 1993; 269:2398-402. Google Scholar5. Carlisle DM, Siu AL, Keeler EB, McGlynn EA, Kahn KL, Rubenstein LV, et al. HMO vs fee-for-service care of older persons with acute myocardial infarction. Am J Public Health. 1992; 82:1626-30. Google Scholar Author, Article, and Disclosure InformationAffiliations: University of California, Los Angeles, Center for the Health Sciences; Los Angeles, CA 90024 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 June 1994Volume 120, Issue 11Page: 971-972KeywordsHealth care qualityHealth insuranceHerniaHysterectomyMortalityMyocardial infarctionPatientsPneumoniaSurgeonsVaccines ePublished: 15 August 2000 Issue Published: 1 June 1994 Copyright & PermissionsCopyright © 1994 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Scombroid fish poisoning. Outbreak traced to commercially canned tuna fish
Authors: M. H. Merson
Journal: JAMA (1974)

In February 1973, scombroid fish poisoning occurred in 232 persons who had eaten from either of two lots of commercially canned tuna. Cases occurred in four states, with no reported hospitalizations or deaths. Patients became ill about 45 minutes after eating the fish; symptoms lasted about eight hours. Contaminated fish contained histamine levels of 68 to 280 mg/100 gm of fish muscle. (<i>JAMA</i>228:1268-1269, 1974)
The effect of strawberries in a cholesterol-lowering dietary portfolio
Authors: David J.A. Jenkins, Tri H. Nguyen, Cyril W.C. Kendall, Dorothea A. Faulkner, Balachandran Bashyam, In Joo Kim, Chris Ireland, Darshna Patel, Edward Vidgen, Andrea R. Josse, Howard D. Sesso, Britt Burton-Freeman, Robert G. Josse, Lawrence A. Leiter, William Singer
Journal: Metabolism (2008)
Aurora B is dispensable for megakaryocyte polyploidization, but contributes to the endomitotic process
Authors: Larissa Lordier, Yunhua Chang, Abdelali Jalil, Frédéric Aurade, Loïc Garçon, Yann Lécluse, Frédéric Larbret, Toshiyuki Kawashima, Toshio Kitamura, Jérôme Larghero, Najet Debili, William Vainchenker
Journal: Blood (2010)
Expanded 2-Year Follow-up of Ranibizumab Plus Prompt or Deferred Laser or Triamcinolone Plus Prompt Laser for Diabetic Macular Edema
Authors: Michael J. Elman, Neil M. Bressler, Haijing Qin, Roy W. Beck, Frederick L. Ferris, Scott M. Friedman, Adam R. Glassman, Ingrid U. Scott, Cynthia R. Stockdale, Jennifer K. Sun
Journal: Ophthalmology (2011)
Newly Identified Events in the RE-LY Trial
Authors: Stuart J. Connolly, Michael D. Ezekowitz, Salim Yusuf, Paul A. Reilly, Lars Wallentin
Journal: New England Journal of Medicine (2010)

To the Editor: We wish to update our article about the Randomized Evaluation of Long-Term Anticoagulation Therapy (RE-LY) trial (Sept. 17, 2009, issue).1 After the database was locked on August 15, 2009, we identified several additional primary efficacy and safety outcome events during routine clinical site closure visits. These events included two systemic embolic events and nine major hemorrhages. Subsequently, after discussions with the Food and Drug Administration, the primary and secondary efficacy and safety data were checked for consistency, and the study database was reevaluated for possible underreporting of events. To achieve this, all free text, outcomes, and adverse . . .
Teaching Problem-Solving — How Are We Doing?
Authors: Jerome P. Kassirer
Journal: New England Journal of Medicine (1995)

The Clinical Problem-Solving exercise in this issue of the Journal, entitled “Costly Errors,”1 contains many valuable lessons about the diagnosis and treatment of autoimmune hemolytic anemia — lessons learned from a regrettable and flawed approach to a patient with this disorder. Because we have been criticized in the past for describing cases of substandard medical care in this series,26 it seems timely to explain why we have chosen certain cases for the series and to offer some suggestions about how to teach and learn the principles of diagnosis.For decades no attempt was made to teach diagnosis as a . . .
From budgets to babies
Authors: J. Warden
Journal: BMJ (1988)

<h3>Introduction</h3> The prevalence of attention deficit hyperactivity disorder (ADHD) within the Children and Young People Secure Estate (CYPSE) is much higher than seen in the general population. To make a diagnosis of ADHD, clinicians draw on information from multiple sources, including parents and teachers. However, obtaining these is particularly difficult for young people in the secure estate. There is increasing evidence in the community that QbTest is able to assist in the accurate and earlier diagnosis of ADHD. The objective of this study is to assess the feasibility and acceptability of QbTest in the assessment of ADHD within the CYPSE. <h3>Methods and analysis</h3> A single-centre parallel group feasibility randomised controlled trial will be conducted. Sixty young people within the CYPSE identified as displaying possible symptoms of ADHD will be randomised to the intervention arm (n=30; QbTest plus usual care) or control arm (n=30; usual care). Primary analyses will be descriptive and a process evaluation will be conducted to assess the contexts involved in implementing the intervention. Interviews will be conducted to explore acceptability and thematic analysis will be used to analyse the data. <h3>Ethics and dissemination</h3> This study was approved by National Health Service Wales research ethics committee 3 (18/WA/0347) on 15 February 2019. The findings will be published in peer-reviewed journals, presented at relevant conferences and disseminated to the public via summaries cocreated with our patient and public involvement group. <h3>Trial registration number</h3> ISRCTN17402196
Effect of aspirin on nasal resistance to airflow.
Authors: A S Jones, J M Lancer, A A Moir, J C Stevens
Journal: BMJ (1985)

The effect of aspirin on nasal resistance to airflow was investigated by rhinomanometry in 25 healthy subjects before and after ingestion of aspirin or vitamin C in a double blind crossover trial. Aspirin caused a significant increase in nasal resistance compared with vitamin C. The effect of aspirin may be due to its inhibition of the synthesis of prostaglandins.
Domperidone Should Not Be Considered a No-Risk Alternative to Cisapride in the Treatment of Gastrointestinal Motility Disorders
Authors: Benoit Drolet, Guy Rousseau, Pascal Daleau, René Cardinal, Jacques Turgeon
Journal: Circulation (2000)

Background —Several cases of QT prolongation and ventricular tachyarrhythmia have been reported with domperidone, a gastrokinetic and antiemetic agent available worldwide but still under investigation in the United States. Although electrolyte disturbances such as hypokalemia could account for some of these events, we hypothesized that domperidone may have unsuspected electrophysiological effects predisposing some patients to proarrhythmia. Methods and Results —Studies were undertaken in 9 isolated guinea pig hearts, which demonstrated reverse use–dependent prolongation of cardiac repolarization by 100 nmol/L domperidone. Action potential duration increased 27% from baseline with domperidone (from 114±3 to 145±2 ms) during pacing at a cycle length of 250 ms, and a 9% increase (from 97±2 to 106±3 ms) was seen with pacing at a cycle length of 150 ms. Experiments in human ether-a-go-go–related gene (HERG)-transfected Chinese hamster ovary cells (n=32) demonstrated a concentration-dependent block of the rapid component (I Kr ) of the delayed rectifier potassium current. The tail current decreased by 50% at 162 nmol/L domperidone. Conclusions —Domperidone possesses cardiac electrophysiological effects similar to those of cisapride and class III antiarrhythmic drugs. These effects are observed at clinically relevant concentrations of the drug. Therefore, domperidone should not be considered a no-risk alternative to cisapride, a drug that was recently withdrawn from the US market.
Aspirin and Aspirin Products
Authors: Hugh H. Hussey
Journal: JAMA (1974)

An earlier editorial inThe Journal, "Aspirin Can Be Dangerous" (228:609, 1974), called attention to the risk of administering aspirin or aspirin-containing compounds to patients with a hemorrhagic diathesis, especially hemophilia, or to patients with a propensity for or a history of peptic ulcer. That editorial was based in part on a report by Binder et al<sup>1</sup>who demonstrated that the bleeding time is not prolonged after oral administration of propoxyphene hydrochloride (Darvon), 64 mg; choline salicylate (Arthropan), 870 mg; pentazocine hydrochloride (Talwin), 50 mg; prednisone, 30 mg; and codeine, 30 mg. The authors concluded that these five drugs could be used safely for their analgesic or anti-inflammatory action in hemophilia. In the course of their report, Binder and his co-workers listed more than 60 aspirin-containing drug products, many of which do not hint by their brand names that they contain aspirin and can be purchased without a prescription.