MUSTARD CHEMOTHERAPY IN OVARIAN CARCINOMA
Authors: E V COONRAD, R W RUNDLES
Journal: Annals of Internal Medicine (1959)

Article1 June 1959MUSTARD CHEMOTHERAPY IN OVARIAN CARCINOMAEVELYN V. COONRAD, R. W. RUNDLES, F.A.C.P.EVELYN V. COONRADSearch for more papers by this author, R. W. RUNDLES, F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-50-6-1449 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptOvarian carcinoma is the third most common malignancy arising from the female genital tract, and the one least amenable to successful treatment.1, 2The tumor is notoriously "silent." Its discovery at an early stage is difficult, even in women who have frequent, routine pelvic examinations. Papanicolaou cytologic studies ordinarily give no clue as to its presence, and symptoms are unusual until invasion of the retroperitoneal pelvic tissues, bladder or bowel wall or intraperitoneal spread has occurred. At operation, viable tumor cells have been found in peritoneal washings in the great majority of patients, including many of those without visible metastases.3,...Bibliography1. Randall JH: Treatment of ovarian carcinoma, Obst. and Gynec. 5: 445, 1955. Google Scholar2. Taylor HC: Treatment of carcinoma of the ovary—surgical aspects, Proceedings of the Third National Cancer Conference, 1956, J. B. Lippincott Company, Philadelphia, pp. 693-698. Google Scholar3. KeettelElkins WCHB: Experience with radioactive colloidal gold in the treatment of ovarian carcinoma, Am. J. Obst. and Gynec. 71: 553, 1956. CrossrefMedlineGoogle Scholar4. Elkins HB: Radiation in the treatment of carcinoma of the ovary, Proceedings of the Third National Cancer Conference, 1956, J. B. Lippincott Company, Philadelphia, pp. 699-702. Google Scholar5. RandallGerhardt CLPR: The probability of the occurrence of the more common types of gynecologic malignancy, Am. J. Obst. and Gynec. 68: 1378, 1954. MedlineGoogle Scholar6. KrohnJaffeIzenstark LHLJL: Postoperative radiation therapy for ovarian cancer, Obst. and Gynec. 9: 111, 1957. Google Scholar7. RundlesBarton RWWB: Triethylene melamine in the treatment of neoplastic disease, Blood 7: 483, 1952. CrossrefMedlineGoogle Scholar8. SykesRundlesPierceKarnofsky MPRWVKDA: Triethylene melamine in the management of far advanced ovarian cancer, Surg., Gynec. and Obst. 101: 133, 1955. MedlineGoogle Scholar9. HendersonBean DNJL: Results of treatment of primary ovarian malignancy, Am. J. Obst. and Gynec. 73: 657, 1957. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Durham, North Carolina*Received for publication March 3, 1958.From the Department of Medicine, Duke University School of Medicine, and the Hematology Laboratory, Duke Hospital.†The expenses of this study were defrayed in part from the Anita Bell Ritter Memorial Fund. We are indebted to Dr. James M. Ruegsegger, of the Lederle Laboratories, for generous supplies of TEM, and to Dr. Donald S. Searle, Burroughs Wellcome & Company, for supplies of Chlorambucil (Leukeran).Requests for reprints should be addressed to the authors, Department of Medicine, Duke University School of Medicine, Durham, North Carolina. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byMeigs to modern times: The evolution of debulking surgery in advanced ovarian cancerManagement of Ovarian CarcinomaEffect of Thio-TEPA on Advanced Ovarian CancerMechlorethamineALKYLATING AGENTSManagement of Advanced Ovarian CarcinomaCHLORAMBUCIL IN THE TREATMENT OF PRIMARY ADENOCARCINOMA OF THE OVARYNitrogen Mustards and Related Alkylating AgentsChemotherapy in genital cancer: systemic therapy and regional perfusionChemotherapy in patients with gynecologic cancerPalliation in gynecologic cancerClinical evaluation of cancer chemotherapy with 5-fluorouracilAdvances in cancer chemotherapy 1 June 1959Volume 50, Issue 6Page: 1449-1461KeywordsAdenocarcinomaBladderCellsChemotherapyGenital anatomyHematology and oncologyHospital medicineObstetrics and gynecologyResearch laboratories ePublished: 1 December 2008 Issue Published: 1 June 1959 PDF downloadLoading ...