THE RELATION OF THYROIDAL HORMONE LEVEL TO EPINEPHRINE RESPONSE: A DIAGNOSTIC TEST FOR HYPERTHYROIDISM
Authors: J F MURRAY, J J KELLY
Journal: Annals of Internal Medicine (1959)

Article1 August 1959THE RELATION OF THYROIDAL HORMONE LEVEL TO EPINEPHRINE RESPONSE: A DIAGNOSTIC TEST FOR HYPERTHYROIDISMJOHN F. MURRAY, M.D., JOHN J. KELLY JR., M.D.JOHN F. MURRAY, M.D.Search for more papers by this author, JOHN J. KELLY JR., M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-51-2-309 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptAt the beginning of the present century a keen interest developed in the physiologic properties of the recently discovered hormones of the adrenal medulla and thyroid. In 1908 Eppinger, Falta and Rudinger1suggested that the thyroid hormone potentiated the physiologic effects of epinephrine. In 1918 Goetsch,2reviewing diagnostic methods for hyperthyroidism, drew attention to this early report, and to more recent ones by Cannon and Cattell3and Levy,4which were concerned with the interrelationships of the adrenal medulla, the sympathetic nervous system and the thyroid. So impressed was Goetsch by the increased sensitivity of the thyrotoxic subject to epinephrine that...Bibliography1. EppingerFaltaRudinger HWC: Ueber die Wechselwirkungen der Drüsen mit innerer Sekretion, Ztschr. f. klin. Med. 66: 1, 1908. Google Scholar2. Goetsch E: Newer methods in the diagnosis of thyroid disorders: pathological and clinical, New York State J. Med. 18: 259, 1918. Google Scholar3. CannonCattell WBM: Studies on the conditions of activity in endocrine glands. III. The influence of the adrenal secretion on the thyroid, Am. J. Physiol. 41: 74, 1916. CrossrefGoogle Scholar4. Levy RL: Studies on the conditions of activity in endocrine glands. IV. 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WernerSpooner SCM: A new and simple test for hyperthyroidism employing l-triiodothyronine and the 24 hour I131 uptake method, Bull. New York Acad. Med. 31: 137, 1955. MedlineGoogle Scholar30. Werner SC: Euthyroid patients with early eye signs of Graves' disease, Am. J. Med. 18: 608, 1955. CrossrefMedlineGoogle Scholar31. ZieveSkanseSchulta LBAL: Comparative value of the basal metabolic rate, chemical protein-bound iodine, and radioactive iodine excretion or uptake in the diagnosis of borderline hyperthyroidism when used individually or in combination, J. Lab. and Clin. Med. 45: 281, 1955. MedlineGoogle Scholar32. GoetschRitzmann EAJ: Thyroid disorders. VI. The suprarenal factor in reactions to thyroidectomy, Arch. Surg. 29: 492, 1934. CrossrefGoogle Scholar33. RosenblumHahnLevine HRGSA: Epinephrine: its effect on the cardiac mechanism in experimental hyperthyroidism and hypothyroidism, Arch. Int. Med. 51: 279, 1933. CrossrefGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Brooklyn, N. Y.*Received for publication November 17, 1958.From the Department of Medicine, State University of New York Downstate Medical Center, Brooklyn, N. Y.This work was supported by Grant H-1250 (C) from the Department of Health, Education, and Welfare, U. S. Public Health Service, National Institutes of Health, Bethesda, Maryland.†Present address: Department of Medicine, University of California Medical Center, Los Angeles 24, California.Requests for reprints should be addressed to John J. Kelly, Jr., M.D., Associate Professor of Medicine, State University of New York, Downstate Medical Center, 450 Clarkson Avenue, Brooklyn 3, N. Y. 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