tbuckley/cabot-search huggingface dataset:
938. Myocardial Administration of Adenoviral Vector Encoding VEGF Induces Severe Pleural and Pericardial Effusion in Rat
Authors: Yoshinori Ito, Masayoshi Kobune, Takeshi Uzuka, Jinghua Huang, Yukiko Honma, Hironari Dehari, Hikaru Ueno, Hirofumi Hamada
Journal: Molecular Therapy (2004)

Background: Clinical trials for severe coronary ischemia and critical limb ischemia using vascular endothelial growth factor (VEGF) gene have been on going for several years. However, the indication of VEGF therapy for ischemic heart disease is only limited to chronic ischemia, and acute myocardial infarction (AMI) is exception for this therapy at present. High levels of circulating VEGF were reported to arise following AMI in a short period after the ischemic event and surmised that it protects the blood vessels from apoptosis, modulates vasomotor response, and supports vessel formation in the ischemic area, and to contribute to quick recovery from the ischemic state. In this regard, we attempted adenoviral VEGF gene therapy for rat myocardial infarction model. However, we found the increase mortality of animals receiving adenoviral VEGF. Therefore, we re-evaluated the adverse effect of myocardial administration of adenoviral vector encoding VEGF in AMI rat.
Practical Handbook of the Pathology of the Skin: An Introduction to the Histology, Pathology, Bacteriology and Mycology of the Skin With Special Reference to Technique
Authors: J. M. H. Macleod, I. Muende
Journal: JAMA (1941)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Relationship of aggressive behavior to other neuropsychiatric symptoms in patients with Alzheimer's disease
Authors: D Aarsland, J L Cummings, G Yenner, B Miller
Journal: American Journal of Psychiatry (1996)

This study explored the relationship between aggressive behavior and other neuropsychiatric symptoms in patients with Alzheimer's disease.Consecutively assessed outpatients with probable or possible Alzheimer's disease (N = 75) were assessed with the Behavioral Pathology in Alzheimer's Disease Rating Scale and the Hamilton Depression Rating Scale.Twenty-five patients (33%) had verbal outbursts and 13 patients (17%) engaged in physical aggression in the month prior to assessment. Aggressive patients and nonaggressive patients did not differ regarding age, education, gender, level of depression, or severity of dementia. In the entire group, dysphoria was found in 33%, delusional ideation in 39%, and hallucinations in 16%. Aggressive behavior was more frequent among patients with hallucinations than among those without. Scores on hallucinations and activity disturbance predicted 12% of the variance in total aggressive behavior. When data from patients taking psychotropic medication were excluded from the analysis, hallucination and delusion scores predicted 22% of the variance in the aggression score. Physical aggression was associated with activity disturbance and hallucinations, and verbal aggression was associated with delusional ideation. No other clinical correlates of aggression were identified.Aggressive behavior is a frequent behavioral symptom in Alzheimer's disease. About one-fourth of the variance in aggression could be attributed to psychosis.
Asbestos Exposure and Neoplasia
Authors: I. J. Selikoff, J. Churg, E. C. Hammond
Journal: CA A Cancer Journal for Clinicians (1984)

Building trades insulation workers have relatively light, intermittent exposure to asbestos. Of 632 insulation workers, who entered the trade before 1943 and were traced through 1962, 45 died of cancer of the lung or pleura, whereas only 6.6 such deaths were expected. Three of the pleural tumors were mesotheliomas; there was also one peritoneal mesothelioma. Four mesotheliomas in a total of 255 deaths is an exceedingly high incidence for such a rare tumor. In addition, an unexpectedly large number of men died of cancer of the stomach, colon, or rectum (29 compared with 9.4 expected). Other cancers were not increased; 20.5 were expected, and 21 occurred. Twelve men died of asbestosis.
A comparison of panic disorder and generalized anxiety disorder
Authors: Dorothy J. Anderson, Russell Noyes, Raymond R. Crowe
Journal: American Journal of Psychiatry (1984)

Subjects from a family study who had panic disorder and generalized anxiety disorder were compared on the pattern of their symptoms, age and type of onset, personality characteristics, course of illness, and outcome. Subjects with generalized anxiety disorder were shown to have fewer autonomic symptoms and an earlier, more gradual onset. Their illness was also observed to have a more chronic course and a more favorable outcome, although these differences were not statistically significant. The validity of generalized anxiety disorder and panic disorder as discrete diagnostic entities is supported.
A systematic review of worldwide incidence of nonmelanoma skin cancer
Authors: A. Lomas, J. Leonardi‐Bee, F. Bath‐Hextall
Journal: British Journal of Dermatology (2012)

Background Nonmelanoma skin cancer (NMSC) is the most common cancer affecting white‐skinned individuals and the incidence is increasing worldwide. Objectives This systematic review brings together 75 studies conducted over the past half century to look at geographical variations and trends worldwide in NMSC, and specifically incidence data are compared with recent U.K. cancer registry data. Methods Following the development of a comprehensive search strategy, an assessment tool was adapted to look at the methodological quality of the eligible studies. Results Most of the studies focused on white populations in Europe, the U.S.A. and Australia; however, limited data were available for other skin types in regions such as Africa. Worldwide the incidence for NMSC varies widely with the highest rates in Australia [> 1000/100 000 person‐years for basal cell carcinoma (BCC)] and the lowest rates in parts of Africa (< 1/100 000 person‐years for BCC). The average incidence rates in England were 76·21/100 000 person‐years and 22·65/100 000 person‐years for BCC and squamous cell carcinoma (SCC), respectively, with highest rates in the South‐West of England (121·29/100 000 person‐years for BCC and 33·02/100 000 person‐years for SCC) and lowest rates by far in London (0·24/100 000 person‐years for BCC and 14·98/100 000 person‐years for SCC). The incidence rates in the U.K. appear to be increasing at a greater rate when compared with the rest of Europe. Conclusions NMSC is an increasing problem for health care services worldwide. This review highlights a requirement for prevention studies in this area and the issues surrounding incomplete NMSC registration. Registration standards of NMSC should be improved to the level of other invasive disease.
A region on chromosome 3 is linked to dizygotic twinning
Authors: Andreas Busjahn, Hans Knoblauch, Hans-Dieter Faulhaber, Atakan Aydin, Regina Uhlmann, Jaakko Tuomilehto, Jaakko Kaprio, Piotr Jedrusik, Andrzej Januszewicz, Jan Strelau, Herbert Schuster, Friedrich C. Luft, Bertram Müller-Myhsok
Journal: Nature Genetics (2000)
Ruxolitinib In Myelofibrosis (MF) Patients Through Compassionate Use Program (CUP). Argentinian Experience
Authors: Mauricio A Alzate, María J Mela Osorio, Paula Barreyro, Alicia Inés Enrico, Ana García de Labanca, Pedro Negri, Ana Inés Varela, Adriana Vitriu, Daniel Bär, Ricardo Benzadón, Rubén Burgos, Lucía Celebrín, Jose Manuel Ceresetto, Ariel Corzo, Isolda Fernández, María Gabriela Flores, Ana Victoria Galeazzi, Emilio A Lanari Zubiaur, Felisa C. Molinas, Sergio M Orlando, Miguel A Pavlovsky, Guillermina Remaggi, Dardo Alberto Riveros, Silvia Rudoy, Gustavo Taborda, Julio César Sánchez Avalos, Federico Sackmann, Raquel M Bengió
Journal: Blood (2013)
Extracellular matrix proteins protect small cell lung cancer cells against apoptosis: A mechanism for small cell lung cancer growth and drug resistance in vivo
Authors: Tariq Sethi, Robert C. Rintoul, Sarah M. Moore, Alison C. MacKinnon, Donald Salter, Chin Choo, Edwin R. Chilvers, Ian Dransfield, Seamas C. Donnelly, Robert Strieter, Christopher Haslett
Journal: Nature Medicine (1999)
Pathophysiology: Altered Regulatory Mechanisms in Disease.
Authors: Edward D. Frohlich
Journal: Annals of Internal Medicine (1985)

Book reviews abnormal whereas they are probably artefactual.The appearance of an in- nervated motor end-plate in 'denervated' muscle (plate 65) is puzzling.The bibliography is useful and includes references to work on experimental animal as well as human muscle.Although this book will not help the reader to understand the significance of the abnormalities illus- trated and makes no attempt to explain their pathogenesis it should be of interest to those involved in the study of muscle.
Does pathological response after transarterial chemoembolization for hepatocellular carcinoma in cirrhotic patients with cirrhosis predict outcome after liver resection or transplantation?
Authors: Marc-Antoine Allard, Mylène Sebagh, Aldrick Ruiz, Catherine Guettier, Bernard Paule, Eric Vibert, Antonio Sa Cunha, Daniel Cherqui, Didier Samuel, Henri Bismuth, Denis Castaing, René Adam
Journal: Journal of Hepatology (2015)
Abstract 157: Lapatinib induces IL-6 expression via MAPK pathway in triple-negative breast cancer cells
Authors: Yu-Chun Hsiao, Yun-Ju Chen, Chih-Hsin Tang, Wei-Chien Huang
Journal: Cancer Research (2014)

Abstract Lapatinib, the dual epidermal growth factor receptor (EGFR) and HER2 tyrosine kinase inhibitor (TKI), have been tested in triple negative breast cancer (TNBC) patients in several clinical studies. However, limited clinic benefit was observed, and the metastatic ability of TNBC cells was even unexpectedly enhanced by these anti-cancer drugs in our previous studies. In this study, we found that induction of interleukin-6 (IL-6) expression was induced in lapatinib-treated cells to contribute to their increased ability of migration. Treatment of cells with the IL-6 antibody abolished the lapatinib-induced cell migration. In response to lapatinib treatment, Raf-1, Mitogen-activated protein kinases (MAPK), c-Jun N-terminal kinases (JNK), p38 mitogen activated protein kinase (p38 or p38-MAPK), and activator protein 1 (AP-1) signaling pathways were activated to mediated the induction of IL-6 level. Furthermore, downregulation of miR-7 was found to result in the lapatinib-induced activation of Raf-1signaling pathway and IL-6 expression. Taken together, our results indicated that lapatinib enhanced the migratory ability of TNBC by increasing IL-6 expression via the Raf-1, MAPK, JNK, p38, and AP-1 pathways. Citation Format: Yu-Chun Hsiao, Yun-Ju Chen, Chih-Hsin Tang, Wei-Chien Huang. Lapatinib induces IL-6 expression via MAPK pathway in triple-negative breast cancer cells. [abstract]. In: Proceedings of the 105th Annual Meeting of the American Association for Cancer Research; 2014 Apr 5-9; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2014;74(19 Suppl):Abstract nr 157. doi:10.1158/1538-7445.AM2014-157
Molecular characterization of dermatophytes of the <i>Trichophyton mentagrophytes</i> complex found in Taiwan with emphasis on their correlation with clinical observations
Authors: P.-L. Sun, H.-M. Hsieh, Y.-M. Ju, S.-H. Jee
Journal: British Journal of Dermatology (2010)

Fungi of the Trichophyton mentagrophytes complex are important pathogenic dermatophytes capable of causing various human skin infections. There are many species and varieties involved in this complex. Due to morphological similarity and existing intermediate forms and variants, unequivocally separating these dermatophytes is not always straightforward, and sampling appropriate isolates for research is often troublesome. Communicating epidemiological statistics of these dermatophytes is greatly impeded because taxonomic schemes adopted by different research groups are inconsistent and hardly comparable.To analyse the molecular types existing within isolates of the T. mentagrophytes complex in Taiwan and evaluate the applicability of the current taxonomy on these isolates.Forty-eight isolates of the T. mentagrophytes complex were obtained from humans and animals (rabbit, guinea pig and hedgehog) in Taiwan. Sequences of ITS1-5.8S-ITS2 and b-tubulin gene regions of each isolate were used for molecular typing.Among the 48 isolates, 43 belonged to the T. interdigitale clade, including 21 of the anthropophilic strain and 22 of the zoophilic strain, and five belonged to the T. erinacei clade. No isolates of the T. mentagrophytes genotype were found.The isolates previously identified as T. mentagrophytes should be relabelled as T. interdigitale according to current taxonomy. Because the taxonomy is quite different from what it used to be, confusion in the nomenclature of the T. mentagrophytes complex is to be expected. The applicability of the current taxonomic concept may require further evaluation.
Abstract 1821: HER3 activation by MET contributes to trastuzumab resistance in HER2-positive breast cancer
Authors: Kenji Hashimoto, Valentine Macaulay, Anthony Kong
Journal: Cancer Research (2014)

Abstract Background: Trastuzumab is a standard therapy for HER2-positive breast cancer patients. Majority of the patients treated with trastuzumab in metastatic disease experience relapse. MET has been reported as one possible candidate of trastuzumab resistance however, detailed mechanism is unclear. Methods: Using panel of HER2-positive cell lines, pHER3 level was assessed with trastuzumab treatment by western blot. Co-immunoprecipitation and siRNA knockdown were used to assess the interaction between HER3 and MET. Results: Phospho-HER3 as well as pAKT levels were decreased after trastuzumab treatment in trastuzumab sensitive cell lines, while there were no deactivation in the resistant cell lines. In the primary trastuzumab resistant cell lines, 5 of 6 cells expressed MET while only one of 4 cells expressed MET in the sensitive cell lines. BT474 cells were found to have increased MET level when the cells acquired resistance to trastuzumab. HCC1954 cells, MET overexpressing and primary trastuzumab cell line, were sensitized to trastuzumab when MET was knocked down. MET knockdown led to a decrease of phosphor-HER3 level in HCC1954, BT474, and BT474 trastuzumab resistant (BT-TR) cells. The paraffin-embedded tumor samples from BT474 xenograft treated with trastuzumab and HER2-positive breast cancer patients will be stained for MET expression to assess its prognostic and predictive values sin HER2 positive breast cancer. Conclusion: MET may play a key role in maintaining HER3 phosphorylation during trastuzumab treatment and resistance in HER2 positive breast cancer. Citation Format: Kenji Hashimoto, Valentine Macaulay, Anthony Kong. HER3 activation by MET contributes to trastuzumab resistance in HER2-positive breast cancer. [abstract]. In: Proceedings of the 105th Annual Meeting of the American Association for Cancer Research; 2014 Apr 5-9; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2014;74(19 Suppl):Abstract nr 1821. doi:10.1158/1538-7445.AM2014-1821
Abstract P165: Leverage-assisted Active Compression-decompression Cardiopulmonary Resuscitation: Comparison of Physical Demands with Manual Active Compression-decompression and Standard Cardiopulmonary Resuscitation
Authors: Chiao-Hao Lee, Ssu-Yuan Chen, Matthew Huei-Ming Ma, Yeou-Bin Guu, Yu-Mei Chen, Yu-Tsung Chen, Huang-Fu Yeh, Jin-Shin Lai, Shyr-Chyr Chen, Wen-Jone Chen, Wei-Tien Chang
Journal: Circulation (2008)

Background: Active compression-decompression (ACD) cardiopulmonary resuscitation (CPR) can potentially improve CPR hemodynamics and survival outcomes. However, its application is limited by technical difficulty and increased physical demands. We therefore develop a leverage-assisted ACD (L-ACD) CPR device aiming at labor-saving, efficiency and ease of performance. Methods: Using a backboard-braced leverage adjunct, we connected the ACD suction cup to one end of the lever, with downward compression and upward decompression controlled by alternative downward pushing of both lever bars. The physiological parameters of the rescuers were compared between L-ACD CPR and traditional manual ACD and standard CPR. The participants first received a maximal exercise test, and then performed 6 min of each type of CPR on 3 separate days. The rate and magnitudes of compression and decompression were in accordance with the AHA guidelines, and were real-time monitored to ensure CPR quality. Physiological parameters includi...
Abstract 12171: Biomarkers and Echocardiographic Predictors of Myocardial Dysfunction in Patients With Hypertension
Authors: Agata Bielecka-Dabrowa, Marta Michalska-Kasiczak, Anna Gluba, Jacek Rysz, Maciej Banach
Journal: Circulation (2014)

Introduction: The aim of the study was to clarify the basis of exertional dyspnea in patients with hypertension with well-controlled blood pressure and normal ejection fraction (EF). Methods: 99 patients with hypertension of mean age 63±11 years: group A - 22 patients without symptoms; group B - 27 patients with exertional dyspnea; group C - 50 patients with overt heart failure (HF). Patients in groups A and B had normal resting echocardiography.Patients underwent echocardiography at rest and during submaximal exercise on a bicycle ergometer; cardiotrophin-1, cystatin C (CysC), syndecan-4, collagen III N-terminal propeptide (PIIINP), transforming growth factor beta (TGF-beta), tumor necrosis factor alpha (TNF-alpha), interleukin 1 receptor, type I (IL1R1), galectin-3 and N-terminal pro-brain natriuretic peptide (NT-proBNP) were measured. Results: In test group B the level of PIIINP was higher than in group A (2.9±0.94 vs 1.27±1.03 ng/ml; p=0.0001). Patients in groups A and B were characterized by lower levels of cardiotrophin-1, syndecan-4, NT-proBNP, and CysC than in group C. The concentration of TGF-beta was lower in group C than in A and B (p=0.000). Groups A and B had comparable echocardiographic findings at rest except isovolumic relaxation time, which was higher in group B (104.87±19 vs 89.4±26 ms; p=0.03). In exertional echocardiography the patients from group B compared with group A had lower E’ and S’ according to tissue Doppler imaging(12.83±1 vs 14.94±3, p=0.02; 9.35±2 vs 10.98±2; p=0.01) and E/E’ ratio was increased in the symptomatic group as compared to controls (6.99±1 vs 5.91±1; p=0.03). A late diastolic mitral annular velocity (A') increase was observed in group A and a reduction in group B with a significant difference in [[Unable to Display Character: &amp;#8710;]]A’ between these two groups (-0.62±2.46 vs 1.22±3.41; p=0.04). Conclusions: PIIINP might be the first early biomarker for the development of HF in patients with hypertension. Patients with normal resting echocardiography can present exercise intolerance and breathlessness associated with reduced left atrial function, worse left ventricular relaxation and impaired function of the longitudinal fibers of myocardium on exercise. Exertional echocardiography may indicate patients with incipient HF with preserved EF.
LVH in AV disease.
Authors: J Ferlinz
Journal: Circulation (1976)

A recent article by Trenouth et al. (Circulation 53: 644, 1976) is a significant contribution to our understanding of the patho- physiology of the chronic aortic valvular disease accompanied by left ventricular hypertrophy (LVH).Unfortunately, a number of statements and assumptions have been made by the authors which
Diabetic Retinopathy Mechanism Probed
Authors: Mike Mitka
Journal: JAMA (2005)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal