tbuckley/cabot-search huggingface dataset:
RELATIONSHIP PROBLEMS BETWEEN CORRECTIONAL AND PSYCHIATRIC STAFFS IN A PRISON HOSPITAL
Authors: RICHARD A. STAMM
Journal: American Journal of Psychiatry (1962)

This paper has tried to describe a dichotomous relationship between correctional and psychiatric staffs in a prison hospital. Our efforts have been directed towards understanding and fulfilling some of the needs we and correctional officers have while working together in such an institution. With resolution of some of these conflicts, we have moved toward a more integrated approach to the treatment of patients, under direction of the psychiatrist, in an administrative setup which starts out as being a more rigid dichotomy of responsibility.
Neutrophilic Agranulocytosis During Administration of Penicillamine
Authors: Jesué M. Corcos, Jaoquín Soler-Bechara, Klaus Mayer, Richard H. Freyberg, Robert Goldstein, Israeli Jaffe
Journal: JAMA (1964)

Neutrophilic agranulocytosis developed in two patients with rheumatoid arthritis within the first five weeks of administration of penicillamine (D-penicillamine). One patient died from sepsis, the other recovered after discontinuation of the drug which was resumed at a lower dose without resultant untoward effects. The characteristic hematological findings were compared with those occurring in the course of agranulocytosis caused by other unrelated drugs. In the light of the pathological and laboratory findings, a cytotoxic effect and not an immunologic mechanism was responsible for the neutrophilic agranulocytosis in the patients described. Previous therapy with adrenal corticosteroids in both patients, leading to adrenal cortical insufficiency, may have played a role in the development of the hematological [ill]oxicity.
NASAL GUIDE FOR THE STOMACH TUBE.
Authors: L. H. PRINCE
Journal: JAMA (1891)

The forcible feeding of the insane through the nose with the stomach tube is frequently a most tedious operation, and in many instances becomes an impossibility, and resort is finally had to the use of the mouth-gag, so as to allow of the introduction of the tube through the mouth. As the passing of the tube through the nose, in most cases, is greatly to be preferred, the following is offered as a simple and efficient method whereby the tube may, in nearly if not quite all cases, be quickly and easily passed through the nasal cavity and into the pharynx. The instrument used is very similar in appearance to a small-sized urethral sound. It should be about six inches in length over all, and not more than one-eighth of an inch in diameter from the handle to the extremity, the curvature beginning about an inch and one-quarter from the
Recurrent pseudo-scarlatina and allergy to pseudoephedrine hydrochloride
Authors: B.J. TAYLOR, M.B. DUFFILL
Journal: British Journal of Dermatology (1988)

A case of recurrent pseudo-scarlatina is described. Challenge with pseudoephedrine hydrochloride reproduced a typical attack but pseudoephedrine ingestion could not be related definitely to all episodes. Allergy to pseudoephedrine or codeine should be considered as a cause for recurrent scarlet fever-like eruptions.
Abstract P5-18-18: Lapatinib versus trastuzumab, or both, added to preoperative chemotherapy for breast cancer: A meta-analysis of randomized evidence
Authors: A Valachis, A Nearchou, P Lind
Journal: Cancer Research (2012)

Abstract Purpose: We compared the efficacy and safety of the addition of lapatinib versus trastuzumab, or the combination, to neoadjuvant chemotherapy in HER2-positive breast cancer. Methods: Potentially eligible trials were identified through PubMed and Cochrane Library searches and abstracts of major international conferences. The endpoints that we assessed were pathologic complete response (pCR) rate and toxicity. Pooled relative risks (RR) were estimated for each endpoint with fixed or random effects models, depending on between-studies heterogeneity. Results: Six trials were identified with 1494 eligible patients. The probability to achieve pCR was higher for the trastuzumab plus chemotherapy arm than lapatinib plus chemotherapy (RR 1.25, 95% Confidence Interval (CI): 1.08–1.43; p-value = 0.003) (6 trials; 1494 patients). Furthermore, the probability for pCR was significantly higher in the group given both lapatinib and trastuzumab than in the group given trastuzumab alone (RR 1.39, 95% CI: 1.20–1.63; p-value &amp;lt; 0.001) (4 trials; 779 patients). Diarrhea and dermatologic toxicities were statistically more frequent in patients receiving lapatinib than trastuzumab. The combination was associated with a higher rate of diarrhea than trastuzumab alone. No differences were observed regarding cardiac adverse events among patients receiving trastuzumab, lapatinib, or the combination. Conclusion: These data support the superiority of a dual-HER2 inhibition for the treatment of HER2-positive breast cancer in the neoadjuvant setting. The direct comparison of trastuzumab and lapatinib demonstrated that lapatinib is inferior in terms of pCR and toxicity. Citation Information: Cancer Res 2012;72(24 Suppl):Abstract nr P5-18-18.
Dame Janet's disappointments: It's not that easy to keep an eye on each other
Authors: William E Osmun
Journal: BMJ (2006)

EDITOR—Firstly, can we put Harold Shipman aside?1 2 What he did was horrible, but basing a system of revalidation on the actions of a psychopathic mass murderer is absurd. No matter what system is put in place, it will not stop the psychopath, just as all the fences in the world will not stop a suicide bomber.

The whole problem with …
Pleuro-pulmonary amoebiasis
Authors: B. T. Le Roux
Journal: Thorax (1969)

Experience with amoebic infestation of the pleural space and the lung in an area where amoebiasis is endemic is described. The manifestations of pleuro-pulmonary amoebiasis are outlined, and, for completeness, a note is added on pericardial amoebiasis and the technique of pericardiocentesis.
TCTAP A-136 Primary Versus Tenecteplase-facilitated Percutaneous Coronary Intervention with Routine Thrombus Aspiration and Closing Device in Patients with STEMI
Authors: Ji Young Park, Jiyoung Park, Sungkee Rye, Seunghwan Kim, Kyngtae Jung, Youjeong Choi
Journal: Journal of the American College of Cardiology (2014)
Is There a Role for β-Blockade in Septic Shock?
Authors: Michael R. Pinsky
Journal: JAMA (2013)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
ABC of healthy travel. Problems facing the traveller.
Authors: E Walker, G Williams
Journal: BMJ (1983)

The numbers of people travelling on "package tours" to Mediterranean countries have increased considerably, and trips to tropical areas such as East Africa or Asia are becoming more popular.In 1981 19m holidays were taken abroad by people living in Britain.Businesses, missionary societies, and "service overseas" schemes may have several hundreds of people overseas at any time, some on short trips, others staying for many years.Air travel has enabled people to visit relatives both for holidays and at short notice to help with family crises.All these groups go through the Ea> upheaval of leaving familiar surroundings and having to cope with unexpected circumstances.Their health may not be protected by services and legislation well established at home.Changes in food and water may bring unexpected problems, as may insects and insect borne diseases, especially in hot countries.Few have at their fingertips the current detailed knowledge needed to advise the traveller going to a particular country, and personal reminiscences may not always reflect current or common problems.A danger of generalising is that it may be forgotten, for example, that malaria is a risk in Turkey, poliomyelitis occurs in Europe, and hepatitis A virus occurs worldwide and is not destroyed by many methods of purifying drinking water.
Reforming research ethics committees
Authors: Richard E Ashcroft, Ainsley J Newson, Piers M W Benn
Journal: BMJ (2005)

For the first 25 years of their existence in the United Kingdom research ethics committees were left more or less in peace by the Department of Health. Since the publication of the “red book” in 1991,1 however, they have undergone a continual process of radical change, from the introduction of multicentre research ethics committees in 1997, through research governance, to various legislative reforms of research practice including the clinical trials regulations of 2004.2–4 Ethical review has been extended to more and more kinds and locations of research. At the same time, ethics committees have been subject to continuous criticism from researchers and public and private sector sponsors of research. Criticism from patients and the public has been less audible.
Effect of reperfusion late in the phase of reversible ischemic injury. Changes in cell volume, electrolytes, metabolites, and ultrastructure.
Authors: R B Jennings, J Schaper, M L Hill, C Steenbergen, K A Reimer
Journal: Circulation Research (1985)

The acute effects of reperfusion on myocardium reversibly damaged by 15 minutes of severe ischemia in vivo, were studied. Changes in the adenine nucleotide pool, cell volume regulation, myocardial calcium, and ultrastructure were studied at the end of 15 minutes of ischemia and after 0.5, 3.0, and 20 minutes of reflow. Before reperfusion, adenosine triphosphate and the adenylate pool decreased by 63% and 44% of control, respectively, and the adenylate charge was reduced to 0.65. After 3 minutes of reperfusion, the adenylate charge was restored to control by the rephosphorylation of adenosine mono- and diphosphate, but adenosine triphosphate was still reduced by 45%. Mild tissue edema was detected after 0.5 minute of reflow and persisted throughout 20 minutes of reperfusion. The increased tissue water was accompanied by a slight increase in sodium and a marked increase in tissue potassium. Although massive calcium accumulation develops when irreversibly injured tissue is reperfused, no calcium overload was detected during early reperfusion of reversibly injured myocytes. Reperfusion for 3 minutes exaggerated the mitochondrial swelling induced by 15 minutes of ischemia but after 20 minutes of reperfusion, myocardial ultrastructure was essentially normal except for rare swollen, or disrupted, mitochondria. Thus, the cellular abnormalities associated with brief periods of ischemia persist for variable periods of time after reperfusion of reversibly injured myocytes. First: although adenine nucleotide repletion occurs very slowly, the adenylate charge was restored after 3 minutes, indicating rapid resumption of mitochondrial adenosine triphosphate production. Second: calcium overload was not detected, but myocardial edema and increased potassium persisted throughout the 20 minutes of reperfusion. Third: the ultrastructural consequences of ischemia were nearly reversed after 20 minutes of reperfusion.
Chikungunya fever is transmitted locally in Europe for first time
Authors: Rory Watson
Journal: BMJ (2007)

Poor communication between primary care trusts and GPs is seriously compromising the safety of patients in England, a group of MPs said this week.In its latest report the House of Commons Committee of Public Accounts also warns that 96% of GPs are failing to report dangerous incidents to the National Patient Safety Agency.For its report, which examines the Department of Health's progress in implementing clinical governance in primary care, the committee had taken evidence from the chief executive of the NHS, the deputy chief medical officer, and the NHS's director general of commissioning.Committee chairman Edward Leigh said, "Too many primary care organisations are paying lip service to the principles of the Department of Health's clinical governance agenda.The lines of communication between the primary care trusts, on the one hand, and their GPs and other healthcare contractors, on the other, are defective."He added: "How can we be confident in the NHS's ability to share learning locally and nationally about what can go wrong in health care when only a tiny proportion of GPs-4%-routinely report patient safety events and incidents to the National Patient Safety Agency?"In response to a series of high profile problems in the 1990s, including the Shipman murders and events at the Bristol Royal Infirmary, the health department introduced its 10 year programme to boost patient safety.The centrepiece was the clinical governance system.The new report suggests, however, that clinical governance is not as well established in primary care as in secondary care.The committee says that this is due largely to the complexity of the role of primary care trusts in commissioning and providing care and to the independence of contractors delivering health care, particularly GPs.The Committee of Public Accounts' 47th report of the current session can be found at www. parliament.uk/pac.Primary� care pay�s only� "lip service" to clinical governance, MPs say� UK NEWS Regulator gives green light to research using human-animal embryos, p 531 WoRld NEWS US me�ical authorities are accuse� o�� ��ailing to act over �octors in �uantanamo, p 53� US me�ical authorities are accuse� o�� ��ailing to act over �octors in �uantanamo, p 53� , p 53� bmj.comNumber o�� bipolar �isor�er �iagnoses leaps among US young people Number o�� bipolar �isor�er �iagnoses leaps among US young people
Abstract 2326: S6K activation is essential for the development of follicular thyroid cancer.
Authors: Valeria Gabriela Antico Arciuch, Antonio Di Cristofano
Journal: Cancer Research (2013)

Abstract The PI3K signaling cascade is frequently activated in follicular and anaplastic thyroid tumors. Mice in which the PI3K pathway is constitutively activated through loss of Pten (PtenL/L;TPO-Cre mice) develop thyroid hyperplasia that progresses to thyroid follicular carcinoma. The wide range of downstream targets of this pathway raises the question of the relative role and relevance of its multiple effectors. This issue has important therapeutic implications, since it would be ideal to only target molecules directly involved in the transformation process, thus reducing the toxicity associated with wide-range inhibitors. PDK1 plays a central role in the PI3K cascade, acting as a master regulator of both AKT and S6K. Notably, PDK1 possesses a substrate docking site named “PIF pocket” that is required to phosphorylate and activate S6K but not AKT. In order to define the relative contribution of Akt and S6k to the development of thyroid lesions and to their progression to follicular carcinoma, we have generated a compound mouse strain in which, in addition to thyroid-specific Pten loss, the PIF-pocket site of Pdk1 can be conditionally disrupted by the L155E mutation, resulting in constitutive activation of Akt and mTor, but not of S6k. We have found that young double mutant mice display a significant reduction in thyroid size, compared to PtenL/L;TPO-Cre mice, and that such rescue is associated with a marked decrease in the thyrocytes proliferation rate. More strikingly, while 60% of Pten mutants develop adenomas and carcinomas by one year of age, none of the age-matched double mutant mice displays neoplastic lesions, indicating that Akt activation, in the absence of S6k activation, is completely unable to drive transformation. Furthermore, we have identified STAT3 as a molecule that is selectively activated downstream of S6k, and that is inactive in double mutants. Pharmacological STAT3 inhibition drastically reduces the proliferation rate of thyroid cancer cell lines, suggesting that STAT3 may be one key conduit of S6k oncogenic activity. Citation Format: Valeria Gabriela Antico Arciuch, Antonio Di Cristofano. S6K activation is essential for the development of follicular thyroid cancer. [abstract]. In: Proceedings of the 104th Annual Meeting of the American Association for Cancer Research; 2013 Apr 6-10; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2013;73(8 Suppl):Abstract nr 2326. doi:10.1158/1538-7445.AM2013-2326
Cachectin/tumor necrosis factor regulates hepatic acute-phase gene expression.
Authors: D H Perlmutter, C A Dinarello, P I Punsal, H R Colten
Journal: Journal of Clinical Investigation (1986)

The monokine, cachectin/tumor necrosis factor (TNF) differs from interleukin 1 (IL-1) in primary structure and in recognition by a distinct cellular receptor. It does, however, encode effector functions that are similar to those of IL-1 and characteristic of the host response to inflammation or tissue injury. Accordingly, we examined the possibility that recombinant-generated human TNF regulates hepatic acute-phase gene expression. In picomolar concentrations, TNF mediated reversible, dose- and time-dependent increases in biosynthesis of complement proteins factor B and C3, alpha 1 antichymotrypsin, and decreases in biosynthesis of albumin and transferrin in human hepatoma cell lines (Hep G2, Hep 3B). Biosynthesis of complement proteins C2 and C4, and alpha 1 proteinase inhibitor were not affected by TNF. TNF also increased factor B gene expression, but had no effect on C2 gene expression, in murine fibroblasts transfected with cosmid DNA bearing the human C2 and factor B genes. The effect of TNF on acute-phase protein expression (C3, factor B, albumin) was pre-translational as shown by changes in specific messenger RNA content.
Young Psychiatrist Administrators
Authors: E. MANSELL PATTISON
Journal: American Journal of Psychiatry (1974)

Administrative issues posed in public community organizations are significantly different from those encountered in mental hospitals and university administrative systems. Thus the development of community mental health delivery systems has created new roles for psychiatric administrators. A survey analysis often young psychiatrist administrators, conducted to assay attitudes and experiences encountered in community mental health administration, revealed that the emergent role of the clinician-executive poses significant problems in the synthesis of role functions and identity. There is a disjunction between professional acculturation and this emergent administrative role.
Dermatofibrosarcoma protuberans is a unique fibrohistiocytic tumour expressing CD34
Authors: SETSUYA AIBA, NOBUKO TABATA, HIROTADA ISHII, HARUO OOTANI, HACHIRO TAGAMI
Journal: British Journal of Dermatology (1992)

Dermatofibrosarcoma protuberans (DFSP) is a slow growing, locally invasive tumour whose differentiation from other fibrohistiocytic tumours sometimes poses serious diagnostic problems. We investigated CD34 expression immunohistologically in various fibrohistiocytic tumours including dermatofibroma, DFSP, malignant fibrous histiocytoma (MFH), infantile myofibromatosis, fibrosarcoma, hypertrophic scar and keloid. Among these, DFSP was unique in that tumour cells themselves expressed CD34, whereas in other tumours. CD34 expression was observed only on vascular endothelial cells amongst the tumour cells. Until now, there have been no reports of useful immunohistological markers for DFSP. CD34 expression by the tumour cells can be an extremely useful marker in establishing a definitive diagnosis of DFSP.
Computation, levels of abstraction, and the intrinsic character of experience
Authors: Jürgen Schröder
Journal: Behavioral and Brain Sciences (1999)

Palmer's color room argument is first contrasted with a different argument by Tim Maudlin against the sufficiency thesis of strong AI. This thesis turns out to be false and hence we need to determine the relevant supervenience base of phenomenal consciousness. That could be done by causal theories and intraindividual experiments. Finally, even if we cannot explain the intrinsic character of conscious states, we may be able to know what the experience of another person is like.
Intermittent dosing of fluticasone propionate cream for reducing the risk of relapse in atopic dermatitis patients
Authors: J. Hanifin, A.K. Gupta, R. Rajagopalan
Journal: British Journal of Dermatology (2002)

Journal Article Intermittent dosing of fluticasone propionate cream for reducing the risk of relapse in atopic dermatitis patients Get access J. Hanifin, J. Hanifin Oregon Health Sciences University, Portland OR, U.S.A Search for other works by this author on: Oxford Academic Google Scholar A.K. Gupta, A.K. Gupta University of Toronto, Toronto, Ontario, Canada Search for other works by this author on: Oxford Academic Google Scholar R. Rajagopalan R. Rajagopalan Glaxo Wellcome Inc., Research Triangle Park, and UNC Pharmacy School, Chapel Hill, NC, U.S.A Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 147, Issue 3, 1 September 2002, Pages 528–537, https://doi.org/10.1046/j.1365-2133.2002.05006.x Published: 01 September 2002 Article history Accepted: 08 April 2002 Published: 01 September 2002
Wavelet Analysis of DNA Walks on the Human and Chimpanzee MAGE/CSAG-Palindromes
Authors: Yanjiao Qi, Nengzhi Jin, Duiyuan Ai
Journal: Genomics Proteomics & Bioinformatics (2012)

Abstract The palindrome is one class of symmetrical duplications with reverse complementary characters, which is widely distributed in many organisms. Graphical representation of DNA sequence provides a simple way of viewing and comparing various genomic structures. Through 3-D DNA walk analysis, the similarity and differences in nucleotide composition, as well as the evolutionary relationship between human and chimpanzee MAGE/CSAG-palindromes, can be clearly revealed. Further wavelet analysis indicated that duplicated segments have irregular patterns compared to their surrounding sequences. However, sequence similarity analysis suggests that there is possible common ancestor between human and chimpanzee MAGE/CSAG-palindromes. Based on the specific distribution and orientation of the repeated sequences, a simple possible evolutionary model of the palindromes is suggested, which may help us to better understand the evolutionary course of the genes and the symmetrical sequences.