tbuckley/cabot-search huggingface dataset:
Peculiarities of the hormonal status and the clinical course of bronchial asthma developed in the perimenopausal period
Authors: Tetyana Chursinova
Journal: European Respiratory Journal (2014)

The aim of this research was to study the clinical course and hormonal status of women with bronchial asthma (BA) which first-time onset in perimenopausal (peri-MP) period.

Methods. The I gr. included 18 women with BA, developed in the peri-MP period, aged from 46 to 54 yrs (mean age 50,94±0,59 yrs). In gr. II included 24 perimenopausal women with asthma, which developed in the reproductive period, age from 44 to 55 yrs (mean age 49,38 ± 0,57 yrs).

Physical examination, serum levels of follicle-stimulating (FSG), luteinizing hormones (LG), estradiol and progesterone were performed.

Results. 

In 4 (22%) patients of I gr. had severe persistent asthma, 12 (67%) women had moderate persistent asthma, and mild persistent asthma was diagnosed only in 2 patients (11%). Comorbidity analysis in patients of I gr. determined that in 11 (61%) patients asthma was associated with allergic rhinitis, in 8 (44%) patients – with sinusitis, obesity I st. was detected in 10 patients (56%) and body mass index (BMI) was ranged from 30.7 to 34.8 kg/m2 (mean 32,57±0,41 kg/m2), in 2 patients (11%) had hypertension. In patients of I gr. had determined a significant decrease of estradiol (p=0.001) and progesterone (p=0.029) compared with hormone concentrations in patients of II gr. There were no significant differences in levels of FSH, LG (p>0,05) between patients of both groups.

Conclusion. Bronchial asthma which developed in the perimenopausal period was characterized by severe and moderate course, patients requiring long-term corticosteroid therapy. Hormonal status of patients was characterized by decreasing levels of estradiol and progesterone, these disorders require correction.
Distribution and Antibody-Induced Redistribution of a Mammary Tumor Virus-Induced and a Normal Antigen on the Surface of Mouse Leukemia Cells2
Authors: J. Hilgers, W. J. van Blitterswijk, W. S. Bont, G. J. Theuns, R. Nusse, J. Haverman, P. Emmelot
Journal: JNCI Journal of the National Cancer Institute (1975)

Journal Article Distribution and Antibody-Induced Redistribution of a Mammary Tumor Virus-Induced and a Normal Antigen on the Surface of Mouse Leukemia Cells Get access J. Hilgers, J. Hilgers Search for other works by this author on: Oxford Academic PubMed Google Scholar W. J. van Blitterswijk, W. J. van Blitterswijk Search for other works by this author on: Oxford Academic PubMed Google Scholar W. S. Bont, W. S. Bont Search for other works by this author on: Oxford Academic PubMed Google Scholar G. J. Theuns, G. J. Theuns Search for other works by this author on: Oxford Academic PubMed Google Scholar R. Nusse, R. Nusse Search for other works by this author on: Oxford Academic PubMed Google Scholar J. Haverman, J. Haverman Search for other works by this author on: Oxford Academic PubMed Google Scholar P. Emmelot P. Emmelot Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 54, Issue 6, June 1975, Pages 1335–1342, https://doi.org/10.1093/jnci/54.6.1335 Published: 01 June 1975 Article history Received: 04 March 1974 Revision received: 18 October 1974 Accepted: 14 February 1975 Published: 01 June 1975
The National Bladder Cancer Study: Employment in the Chemical Industry&lt;xref ref-type="fn" rid="FN2"&gt;2&lt;/xref&gt;
Authors: S H Zahm, P Hartge, R Hoover
Journal: JNCI Journal of the National Cancer Institute (1987)

The relationship between bladder cancer and employment in the chemical industry was assessed in a study of 2,982 incident cases and 5,782 population controls. There were 190 cases and 369 controls who had ever been employed in the chemical industry [odds ratio (OR) = 1.0; 95% confidence interval (CI)=0.8, 1.2]. Employment in the production of organic chemicals was associated with a 1.3-fold increased risk among men (95% CI=0.8, 2.1). Risk increased with duration of employment, reaching an OR of 2.4 for 20 or more years (chi for trend = 1.57; P=.06). Women who had worked in the plastics industry had a 3.3-fold increased bladder cancer risk. Within the plastics and rubber industry, increased risks for bladder cancer were found for men in mixing, filtering, grinding, and other dusty operations (OR=4.6; 95% CI = 1.0, 20.4) and men in heat-associated operations (OR=2.8; 95% CI=0.5, 15.3). A 1.4-fold risk among men in agricultural chemicals was attributable to risks in the pesticides subdivision (OR=2.3; 95% CI=0.6, 8.2). Men performing dusty operations (i.e., mixing, filtering, sifting, grinding, and crushing) in any industry had an OR of 1.4 (95% CI=0.8, 2.7). Despite the large number of study subjects, few statistically significant findings were observed and should be evaluated with consideration of the large number of comparisons made in the analysis. The statistical power of case-control studies to detect risks associated with particular occupational exposures is limited by the small proportion of the population employed in any specific occupation or industry.
National Study of Health and Growth: Effect of change in design with reference to efficiency of mixed longitudinal studies for measuring trends
Authors: S Chinn, R J Rona
Journal: Journal of the Royal Society of Medicine (1987)

The National Study of Health and Growth (NSHG) is a surveillance system which monitors the growth of primary school children in England and Scotland, set up in 1972 following changes in the school milk and welfare system. However, the study contained few children from inner city areas or ethnic minorities. In 1982 its design was changed from one in which the same areas were surveyed every year, to two separate systems with areas surveyed every two years, one set of areas corresponding to those in the original study, and the other set consisting of inner city and ethnic minority areas. The precision of the estimates of trends in height and weight for each system was smaller than that of the original system, but by less than 50%, so that an overall gain in information was achieved. Studies of mixed longitudinal design are shown also to be generally, but not always, less efficient for estimating trends than independent cross-sectional surveys obtaining the same number of measurements.
Diagnostic biopsy before Mohs micrographic surgery, frequency of change in diagnosis and impact on management
Authors: S. Verykiou, T.J. Oliphant, R. Rahim, A. Husain, C.M. Lawrence, J.A. Langtry
Journal: British Journal of Dermatology (2015)

Journal Article Diagnostic biopsy before Mohs micrographic surgery, frequency of change in diagnosis and impact on management Get access S. Verykiou, S. Verykiou Dermatology Department Royal Victoria Infirmary Newcastle upon Tyne NE1 4LP U.K Search for other works by this author on: Oxford Academic Google Scholar T.J. Oliphant, T.J. Oliphant Dermatology Department Royal Victoria Infirmary Newcastle upon Tyne NE1 4LP U.K Search for other works by this author on: Oxford Academic Google Scholar R. Rahim, R. Rahim Dermatology Department Royal Victoria Infirmary Newcastle upon Tyne NE1 4LP U.K Search for other works by this author on: Oxford Academic Google Scholar A. Husain, A. Husain Histopathology Department Royal Victoria Infirmary Newcastle upon Tyne NE1 4LP U.K Search for other works by this author on: Oxford Academic Google Scholar C.M. Lawrence, C.M. Lawrence Dermatology Department Royal Victoria Infirmary Newcastle upon Tyne NE1 4LP U.K Search for other works by this author on: Oxford Academic Google Scholar J.A. Langtry J.A. Langtry Dermatology Department Royal Victoria Infirmary Newcastle upon Tyne NE1 4LP U.K Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 174, Issue 3, 1 March 2016, Pages 649–651, https://doi.org/10.1111/bjd.14186 Published: 01 March 2016
Potentially curative surgery of colon cancer: patterns of failure and survival.
Authors: B D Minsky, C Mies, T A Rich, A Recht, J T Chaffey
Journal: Journal of Clinical Oncology (1988)

In an effort to determine the patterns of failure and survival of colon cancer, a retrospective review of 294 patients who underwent potentially curative surgery at the New England Deaconess Hospital (NEDH) was performed. For the entire group, the 5-year crude survival rate was 68% and the actuarial rate was 80%. Survival decreased with increasing bowel wall penetration by tumor and the presence of lymph node metastasis. Although survival varied with the tumor site, none of the differences was statistically significant. Other variables, including the grade of adenocarcinoma, size, and the type of surgery had a significant impact on survival. Patterns of failure, expressed as the actuarial incidence of first diagnosed failure at 5 years, were examined by stage and site. There was a trend toward increased failure with increasing bowel wall penetration by tumor and the presence of lymph node metastasis. Abdominal failure, either as the only site or as a component of failure, was the most common type of failure. When compared by site, patients with cecal carcinoma had a significantly lower incidence of local and distant failure than patients with disease in other selected sites. No differences in patterns of failure were seen in patients with carcinomas in the mobile sections of the colon compared with those who had disease arising in the nonmobile sections of the colon. These data may be useful in identifying those patients who might benefit most from adjuvant therapy.
The role of transbronchial needle aspiration in the diagnosis of peripheral lung masses or nodules
Authors: K Katis, E Inglesos, E Zachariadis, P Palamidas, I Paraskevopoulos, G Sideris, E Tamvakopoulou, F Apostolopoulou, A Rasidakis
Journal: European Respiratory Journal (1995)

The purpose of this study was to evaluate the role of transbronchial needle aspiration (TBNA) in the diagnosis of peripheral lung lesions. We attempted to perform TBNA in 37 patients referred to our hospital for diagnostic evaluation of radiographically evident peripheral masses (23 cases) or nodules (14 cases). None of them had bronchoscopic evidence of endobronchial lesion. The aspirations were performed under fluoroscopic guidance, through a fibreoptic bronchoscope, employing a 21-gauge, 1.3 cm aspirating needle. They were preceded by bronchial brushing and followed by transbronchial biopsy (TBB) of the peripheral lesion. In two cases, the apical nodules were not accessible by any of these procedures. Bronchial washings were also collected immediately after each procedure (brush, TBNA and TBB). TBNA was diagnostic in 23 of 37 patients (62%) rendering the TBNA yield considerably higher than washing (24%), brushing (27%) or TBB (38%). The addition of TBNA to the combination of TBB, brushing and washing, significantly increased the yield of fibreoptic bronchoscopy in our series from 46% to 70%. No significant complications, such as pneumothorax or major bleeding, occurred either with TBNA or TBB. In conclusion, our findings suggest that transbronchial needle aspiration is a safe procedure, that can improve the diagnostic yield of bronchoscopy in the diagnosis of peripheral lung masses or nodules.
The Coping Behavior of Nazi Concentration Camp Survivors
Authors: JOEL E. DIMSDALE
Journal: American Journal of Psychiatry (1974)

This study of coping strategies reports on interviews with 19 survivors of Nazi concentration camps. The subjects, relatively healthy survivors who were not severely psychiatrically disabled, were interviewed in Jerusalem and the San Francisco Bay area. The author presents a classification of coping strategies in extreme stress situations and discusses the long-term effectiveness of certain of these strategies.
4-Methylumbelliferone inhibits tumour cell growth and the activation of stromal hyaluronan synthesis by melanoma cell-derived factors
Authors: M. Edward, J.A. Quinn, S.M. Pasonen-Seppänen, B.A. McCann, R.H. Tammi
Journal: British Journal of Dermatology (2010)

Background There is a close correlation between tumour progression and hyaluronan production, either by tumour cells or by stromal cells that are stimulated by tumour-derived factors. Inhibition of tumour stimulation of fibroblast hyaluronan may suppress tumour growth and invasion. Objectives To examine the effect of the hyaluronan synthesis inhibitor 4-methylumbelliferone (4-MU) on the growth of and hyaluronan synthesis by fibroblasts and C8161 and MV3 melanoma cell lines, invasion, and inhibition of tumour cell-derived factor activation of fibroblasts. Methods Effects of 4-MU on growth and hyaluronan synthesis by fibroblasts and melanoma cells were examined in monolayer culture and fibroblast-contracted collagen lattices, and their effects on the growth and invasion of tumour cells into collagen lattices were also studied. Results 4-MU caused a dose-dependent growth inhibition of fibroblast and melanoma cells with maximum inhibition at 0·5 mmol L−1 4-MU. At this dose, 4-MU inhibited 3H-glucosamine incorporation into fibroblast glycosaminoglycans by 52%, and hyaluronan synthesis by 64%. The relative inhibition was more pronounced when fibroblasts were stimulated with C8161 melanoma cell-conditioned medium. 4-MU reduced the level of hyaluronan in fibroblast-contracted collagen lattices, and inhibited both the growth on and invasion into the lattices by melanoma cells. This growth inhibition appears to be predominantly independent of inhibition of hyaluronan synthesis. The effect on growth inhibition was reversible, and 4-MU had no effect on apoptosis. Conclusions 4-MU is a potent inhibitor of hyaluronan synthesis, induction of stromal hyaluronan accumulation by tumour cells, and fibroblast and melanoma cell proliferation, and results suggest that 4-MU may have potential as a tumour cell anti-invasive and antiproliferative agent.
Cytotoxic Agents Designed To Be Selective for Liver Cancer2
Authors: A. Bukhari, T. A. Connors, A. M. Gilsenan, W. C. J. Ross, M. J. Tisdale, G. P. Warwick, D. E. V. Wilman
Journal: JNCI Journal of the National Cancer Institute (1973)

A series of azobenzene compounds was prepared containing an alkylating group chemically unreactive because of the deactivating influence of the azo linkage. Members of the series containing a carboxyl group ortho to the azo linkage were readily reduced by rat-liver azo reductase. In some compounds the metabolite formed on reduction was highly cytotoxic but only had a short half life (41 seconds). Such chemicals might be useful in the treatment of liver cancer. The administered alkylating agent was unreactive and nontoxic but was converted in the liver to a toxic metabolite. Because of the rapid hydrolysis of the metabolite, the effects of such compounds may be largely confined to the liver and be less damaging to bone marrow than conventional alkylating agents.
Epidermal growth factor receptor (EGFR) activation is required for TGFβ1-induced epithelial-mesenchymal transition (EMT) in idiopathic pulmonary fibrosis (IPF)
Authors: Hoda Tawel, William Coward, Karl Deacon, Linhua Pang
Journal: European Respiratory Journal (2013)

Introduction: One of the possible sources of myofibroblasts accumulation in IPF is the trans-differentiation of the injured alveolar epithelial cells to myofibroblasts through EMT process. Studies so far suggest that TGFβ1 and EGFR signalling cascades are activated during lung fibrosis. We hypothesized that TGFb1 signalling requires EGFR activation to induce EMT during lung fibrosis.

Material and methods: To address the role of EGFR cascades in TGFβ1-induced EMT, immortalized human bronchial epithelial cells (iHBECs) were treated with or without TGFβ1 (2ng/ml), different concentrations of EGF and EGFR tyrosine kinase inhibitor (AG1478) for 3 days. Expression of the epithelial marker E-cadherin and the mesenchymal marker α-smooth muscle actin (αSMA) was examined by flow cytometry, Western blot and, immunocytochemistry staining. EGFR and Smad2 phosphorylation was measured by Western blot.

Results: Stimulation of iHBECs with TGFβ1 down-regulated E-cadherin expression and increased α-SMA expression. Treatment of the iHBECs with EGF also induced EMT in a concentration-dependent manner and potentiated TGFβ1-induced EMT. Inhibition of EGFR with 2µM AG1478 reduced TGFβ1-induced Smad2 phosphorylation and EMT. TGFβ1 stimulation also induced EGFR expression and phosphorylation which was prevented by AG1478. The data suggests an important role of EGFR activation in TGFβ1-induced EMT. Conclusions: The study has demonstrated that iHBECs undergo EMT in response to TGFβ1 stimulation signified by E-cadherin down-regulation and expression of αSMA and that EGFR signalling is required in TGFβ1-induced EMT.
Identification of viral species in asthma patients with and without aspirin hypersensitivity
Authors: Krzysztof Wójcik, Natalia Celejewska-Wójcik, Krzysztof Pyrc, Anna Golda, Grazyna Bochenek, Lucyna Mastalerz, Marek Sanak
Journal: European Respiratory Journal (2013)

We have shown previously that even in patients with well-controlled asthma the presence of HRV can be detected in bronchial tissue. This phenomenon is more common in aspirin-exacerbated respiratory disease (AERD) but less frequent in subjects without asthma.  We suspected that presence of chronic viral infection can sustain inflammation and may be responsible for bronchial symptoms. In the current study we aimed to screen for and identify viruses present in the airways of asthmatic subjects. The study groups comprised of 50 AERD and 50 asthmatics tolerant to aspirin. The control group consisted of 40 healthy subjects.  Biological specimens included induced sputum, nasal washings and bronchoalveolar lavages. The samples were examined for the presence of several viruses (HCoV-229E, -NL63, -HKU1, influenza A, B, parainfluenza 1, 2, 3, bocavirus, RSV, adenovirus, echovirus 9) using a validated (RT)-PCR technique. In cases where there no known pathogen is found, the material will be tested using VIDISCA and HexaPrime method in order to search for new pathogens.  Our results revealed that in samples from subjects with severe asthma, even in the period without exacerbations, the number of detectable various viral species was increased, as compared to patients with mild-to moderate asthma. We also found more viral species in nasal washings than in induced sputum collected from the same patient. In order to reliably determine the impact of viral infection on the course of the disease a prospective study is ongoing to acquire specimen several times on an annual basis and during exacerbations.  Acknowledgement: PSPB-072/2010 from Switzerland through the Swiss Contribution to the enlarged European Union.
Salmeterol-induced vertigo
Authors: A Lopez-Guillen, L Marques, MT Lopez-Llorente, E Pastor, A Figueras
Journal: European Respiratory Journal (1994)

Dizziness, together with hypotension and faintness, are well-known adverse drug reactions of salbutamol that have been related to its cardiovascular effects. However, we could find no published reference to vertigo in patients taking salmeterol, in the absence of cardiovascular alterations. We present the case of a woman who experienced four independent episodes of vertigo lasting 36 h each, following four inhalations of salmeterol several months apart. The close temporal relationship between the inhalation of salmeterol and the onset of symptoms, as well as the positive re-exposures, reinforce this alleged association.
A Molecular Portrait of High-Grade Ductal Carcinoma <i>In Situ</i>
Authors: Martin C. Abba, Ting Gong, Yue Lu, Jaeho Lee, Yi Zhong, Ezequiel Lacunza, Matias Butti, Yoko Takata, Sally Gaddis, Jianjun Shen, Marcos R. Estecio, Aysegul A. Sahin, C. Marcelo Aldaz
Journal: Cancer Research (2015)

Ductal carcinoma in situ (DCIS) is a noninvasive precursor lesion to invasive breast carcinoma. We still have no understanding on why only some DCIS lesions evolve to invasive cancer whereas others appear not to do so during the life span of the patient. Here, we performed full exome (tumor vs. matching normal), transcriptome, and methylome analysis of 30 pure high-grade DCIS (HG-DCIS) and 10 normal breast epithelial samples. Sixty-two percent of HG-DCIS cases displayed mutations affecting cancer driver genes or potential drivers. Mutations were observed affecting PIK3CA (21% of cases), TP53 (17%), GATA3 (7%), MLL3 (7%) and single cases of mutations affecting CDH1, MAP2K4, TBX3, NF1, ATM, and ARID1A. Significantly, 83% of lesions displayed numerous large chromosomal copy number alterations, suggesting they might precede selection of cancer driver mutations. Integrated pathway-based modeling analysis of RNA-seq data allowed us to identify two DCIS subgroups (DCIS-C1 and DCIS-C2) based on their tumor-intrinsic subtypes, proliferative, immune scores, and in the activity of specific signaling pathways. The more aggressive DCIS-C1 (highly proliferative, basal-like, or ERBB2(+)) displayed signatures characteristic of activated Treg cells (CD4(+)/CD25(+)/FOXP3(+)) and CTLA4(+)/CD86(+) complexes indicative of a tumor-associated immunosuppressive phenotype. Strikingly, all lesions showed evidence of TP53 pathway inactivation. Similarly, ncRNA and methylation profiles reproduce changes observed postinvasion. Among the most significant findings, we observed upregulation of lncRNA HOTAIR in DCIS-C1 lesions and hypermethylation of HOXA5 and SOX genes. We conclude that most HG-DCIS lesions, in spite of representing a preinvasive stage of tumor progression, displayed molecular profiles indistinguishable from invasive breast cancer.
ANGIO-LUPOID OF BROCQ AND PAUTRIER.
Authors: G. AUCKLAND
Journal: British Journal of Dermatology (1950)

Journal Article ANGIO‐LUPOID OF BROCQ AND PAUTRIER: Report of Two Cases Get access G. AUCKLAND, M.B., B.S. G. AUCKLAND, M.B., B.S. Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology and Syphilis, Volume 62, Issue 2, 1 February 1950, Pages 78–82, https://doi.org/10.1111/j.1365-2133.1950.tb10943.x Published: 01 February 1950
Antimicrobial peptide cathelicidin (LL- 37) and human β-defensin 2 in bronchoalveolar lavage fluid of children with pulmonary tuberculosis
Authors: Erkan Cakir, Emel Torun, Ahmet Hakan Gedik, Tarik Umutoglu, Esin Cetin Aktas, Ufuk Topuz, Gunnur Deniz
Journal: European Respiratory Journal (2014)

BACKGROUND:  The antimicrobial peptides cathelicidin LL- 37 /hCAP-18 and human β-defensins (hBD) are the key factors in innate immune responses of the respiratory tract. The aim of this study was to determine the concentrations of LL- 37 and hBD- 2 in BAL fluid of pediatric patients with pulmonary tuberculosis (TB) compared to healthy children.   METHODS:  We measured the concentrations of these peptides using an immunosorbent assays (ELISAs).   RESULTS:  Fourty TB patients and 40 healthy control were enrolled to the study. The mean (±SD) BAL LL- 37 level of the TB group was significantly increased than the control group (0.95±1.33 ng/mL and 0.35±0.51 ng/mL, p=0.01, t=2.54)[Figure 1]. The hBD- 2 level was higher in TB group compared with healthy controls but not reached to a statistically significant level (0.30±0.58 ng/mL and 0.14±0.30 ng/mL, p=0.11) [Figure 2].   CONCLUSIONS:  Our data suggest that LL- 37 and hBD-2 may play an important role in the pathogenesis of TB in children. To our knowledge, this is the first report showing BAL LL- 37 and hBD-2 concentration in children with pulmonary TB.