STUDIES OF B_12 Co^60 ABSORPTION IN MALABSORPTION SYNDROME: RESULTS BEFORE AND DURING SPECIFIC THERAPY
Authors: JOHN W.  FROST, MANFRED I.  GOLDWEIN, BARRE D.  KAUFMAN
Journal: Annals of Internal Medicine (1957)

Article1 August 1957STUDIES OF B12 Co60 ABSORPTION IN MALABSORPTION SYNDROME: RESULTS BEFORE AND DURING SPECIFIC THERAPYJOHN W. FROST, M.D., F.A.C.P., MANFRED I. GOLDWEIN, M.D., BARRE D. KAUFMAN, M.D.JOHN W. FROST, M.D., F.A.C.P.Search for more papers by this author, MANFRED I. GOLDWEIN, M.D.Search for more papers by this author, BARRE D. KAUFMAN, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-47-2-293 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptMalabsorption syndrome can be defined as a disorder resulting from a defect in the intestinal absorption of various substances, including protein, fat, vitamins and minerals. The syndrome is a manifestation of various gastrointestinal disorders, such as sprue, regional enteritis, intestinal strictures and anastomoses, hypogammaglobulinemia and pancreatic dysfunction. In patients with this disorder, variability in the extent of the absorptive defect is often encountered. Relapses and remissions are common.Since there are multiple absorptive defects in the syndrome, numerous tests have been utilized to measure defects in the absorption of fat, protein, carbohydrate and vitamins. The relative simplicity of the technics...Bibliography1. HeinleWelchScharfMeachamPrusoff RWADVGCWH: Studies of excretion (and absorption) of Co60 labelled vitamin B12 in pernicious anemia, Tr. A. Am. Physicians 65: 214, 1952. MedlineGoogle Scholar2. GlassBoydGellinStephanson GBLJGAL: Uptake of radioactive vitamin B12 by the liver in humans: tests for measurement of intestinal absorption of vitamin B12 and intrinsic factor activity, Arch. Biochem. 51: 251, 1954. CrossrefMedlineGoogle Scholar3. Schilling RF: A new test for intrinsic factor activity, J. Lab. and Clin. Med. 42: 946, 1953. Google Scholar4. BestWhiteLouisLemarzi WVWFJLR: Experiences with the Schilling test using Co60 labelled vitamin B12 in pernicious anemia, sprue, and other conditions, J. Lab. and Clin. Med. 44: 767, 1954. Google Scholar5. Glass GB: Intestinal absorption and hepatic uptake of vitamin B12 in diseases of the gastrointestinal tract, Gastroenterology 30: 37, 1956. CrossrefMedlineGoogle Scholar6. HalstedSwendseidLewisGasster JAMAPMM: Mechanisms involved in the development of vitamin B12 deficiency, Gastroenterology 30: 20, 1956. CrossrefGoogle Scholar7. DoscherholmenHagen APS: Absorption of Co60 labelled vitamin B12 in intestinal blind loop megaloblastic anemia, J. Lab. and Clin. Med. 44: 790, 1954. Google Scholar8. Glass GB: Differentiation of macrocytic anemias and detection of pernicious anemia and sprue in remission by accelerated measurement of hepatic uptake of radioactive Co60 B12 , International Society of Hematology, VI Congress, p. 251, 1956. Google Scholar9. Turnbull A: Experiences with labelled vitamin B12 , Proc. Roy. Soc. Med. 47: 42, 1954. Google Scholar10. HalstedLewisGasster JAPMM: Absorption of radioactive B12 in the syndrome of megaloblastic anemia associated with intestinal stricture or anastomosis, Am. J. Med. 20: 42, 1956. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Philadelphia, Pennsylvania*From the Symposium on Diseases of Intestinal Absorption, presented at the Thirty-eighth Annual Session of The American College of Physicians, Boston, Massachusetts, April 9, 1957.From the Hematology Clinic, Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania.†Fellow American Cancer Society.‡Captain (MC) U.S.A.F.Aided by a grant from Eli Lilly & Company, Indianapolis, Indiana.Requests for reprints should be addressed to John W. Frost, M.D., 3400 Spruce St., Philadelphia 4, Pa. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byVitamin B12 Absorption in Cystic FibrosisDie megaloblastischen AnämienCorticotrofina e cortiomdes em neurologia: avaliação critica dos resultados em 518 pacientes hospitalizadosCoeliac DiseaseEfeito da corticotropina sobre a absorção de vitamina B12 na mielose funicularPyridoxine-Responsive Anemia with NeuropathyEUGENE M. BEAUPRE, M.D., PATRICK M. GROWNEY, M.D.The Malabsorption Syndrome, with Special Reference to The Effects of Wheat GlutenMegaloblastic Anaemias of Gastrointestinal OriginRadio-Vitamin B12 in der klinischen DiagnostikVitamin B12 Absorption in Pyridoxine-Deficient RatsPathogenesis of Anemia in a Case of Nontropical SprueObservations on Vitamin B12 Absorption in Primary Pernicious Anemia during Administration of Adrenocortical SteroidsSymposium on problems of intestinal absorption 1 August 1957Volume 47, Issue 2Page: 293-299KeywordsCystic fibrosisEnteritisExcretionFatsHematology and oncologyHospitalsPancreasProteinsSteroid therapyVitamins ePublished: 1 December 2008 Issue Published: 1 August 1957 PDF downloadLoading ...