tbuckley/cabot-search huggingface dataset:
EPISODIC STOMACH CANCER
Authors: I L STOLOFF, T J LATTIMORE
Journal: Annals of Internal Medicine (1955)

Case Reports1 June 1955EPISODIC STOMACH CANCERIRWIN L. STOLOFF, M.D., THOMAS J. LATTIMORE, M.D.IRWIN L. STOLOFF, M.D.Search for more papers by this author, THOMAS J. LATTIMORE, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-42-6-1284 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptIn this era of poor prognosis for stomach cancer we felt it would be encouraging to report the history of a patient who survived three separate stomach resections, each for carcinoma of the stomach. Little has been uncovered in this particular case which gives any insight into the mysteries of cancer; yet we feel that a collection of such peculiar case histories, in which a patient develops multiple tumors of an organ, may yield a common denominator in unraveling the riddle of individual susceptibility to cancer and individual resistance to such tumors once they appear.The case seems worth reporting...Bibliography1. MortonMorton JJJH: Cancer as a chronic disease, Ann. Surg. 137: 683-703 (May) 1953. CrossrefMedlineGoogle Scholar2. KeithOdel NMHM: Outlook for patients with glomerulonephritis, J. A. M. A. 153: 1240-1245 (Dec. 5) 1953. CrossrefMedlineGoogle Scholar3. Wangensteen OH: Cancer of esophagus and stomach, 1951, Monograph of American Cancer Society, New York. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Baltimore, Maryland*Received for publication May 19, 1954.From the Departments of Medicine and Surgery, Baltimore City Hospitals, Baltimore, Maryland. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byIs ‘second look surgery’ justified in suspected recurrences of cancer of the stomach?Carcinoma Twice in the Same StomachHOST-TUMOR ANTAGONISM. XI. RECAPITULATION OF VARIOUS ASPECTS: PRACTICAL APPLICATIONS OF THIS KNOWLEDGE TO THE CARE OF PATIENTS† 1 June 1955Volume 42, Issue 6Page: 1284-1288KeywordsHospital medicineStomachSurgery ePublished: 1 December 2008 Issue Published: 1 June 1955 PDF downloadLoading ...
Why the Americans With Disabilities Act Matters for Genetics
Authors: Ellen Wright Clayton
Journal: JAMA (2015)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Immunologic Aspects of Granulomatous and Interstitial Lung Diseases
Authors: Charles E. Reed
Journal: JAMA (1982)

HYPERSENSITIVITY pneumonitis, also known as extrinsic allergic alveolitis, is a hypersensitivity reaction involving the lung interstitium and terminal bronchioles due to hypersensitivity to antigenic organic dusts. These dusts are most often encountered in occupations or hobbies (see Table 11-1). <h3>HYPERSENSITIVITY PNEUMONITIS—EXTRINSIC ALLERGIC PNEUMONITIS</h3><h3>Prevalence and Etiology</h3> The true prevalence of the disease is unknown. Farmer's lung, pigeon breeder's disease, and disease from contaminated air-conditioning systems are most frequently encountered in the United States. About 8% of dairy farmers have serum precipitins to thermophilic organisms and about 4% have farmer's lung. About 6% to 10% of persons who raise pigeons for a hobby become ill. In some industries up to 10% of exposed individuals have been affected by contaminated air conditioners. Since not everyone exposed equally to these dusts manifests the disease, there are obviously host factors that predispose to this illness, but these have not been defined. <h3>Symptoms and Signs</h3>
Icelandic gene database will uphold patients' rights
Authors: R. Haraldsdottir
Journal: BMJ (1999)

EDITOR—Berger's news story on the Icelandic gene database1 gives an inaccurate and biased account of a complex issue.

The proposed database will not exclude biotechnology companies or pharmaceutical companies from access to data on Icelandic patients, nor are exclusive rights given to one company to develop new drugs or to test candidate drugs. These studies will continue to be allowed as long …
Researchers Seek Roots of Pedophilia
Authors: Lynne Lamberg
Journal: JAMA (2005)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
772. Convective Flow Increases Lipoplex Delivery Rate to In Vitro Cellular Monolayers
Authors: Steven S. Harris, Todd D. Giorgio
Journal: Molecular Therapy (2005)

The mass transport characteristics of cationic, nonviral liposome-DNA plasmid complexes (lipoplexes) were evaluated over a range of fluid shear stresses. The typical case of stagnant flow transfection was expanded to include controlled fluid convection provided by constant flow through a parallel plate flow chamber. Equations describing the transport of lipoplex by sedimentation and convection were derived from theory and solved numerically. Instantaneous lipoplex surface flux and total lipoplex surface delivery during a 72-hour transfection were estimated for two shear stress levels and for static conditions. Theory predicted that lipoplex is delivered to the cell surface more than 12-fold to 19-fold faster through the addition of convection, at least for physiologic shear stresses of 2.3 to 9.7 dynes/cm2, respectively. These calculations were tested experimentally using a cell line (ECV-304) transfected with fluorescently labeled plasmid DNA formulated into a lipoplex. Transfections were conducted during cellular exposure the same known, uniform levels of fluid shear stress presumed in theoretical calculations. Lipoplex delivery was increased by more than 9-fold at 2.3 dynes/cm2 compared to the static case as assessed by flow cytometric measurement. Lipoplex delivery was modestly reduced at the highest fluid shear stress, to 6-fold of the static case, consistent with the disruption of lipoplex-cell binding mediated by hydrodynamic forces. The complicated relationship between fluid convection and lipoplex delivery has important implications for nonviral gene therapy.
Abstract MP05: Mid-Life Vitamin D Levels are Not Associated with Cognition and Dementia Risk in Whites and Blacks: the Atherosclerosis Risk in Communities (ARIC) Study
Authors: Andrea L Schneider, Pamela L Lutsey, Alvaro Alonso, Rebecca F Gottesman, A R Sharrett, Kathryn A Carson, Wendy S Post, David S Knopman, Thomas H Mosley, Erin D Michos
Journal: Circulation (2014)

Introduction: Recent studies, mainly performed in elderly whites, suggest that vitamin D, measured by 25-hydroxyvitamin D [25(OH)D], is important for cognition. Less is known about the association of 25(OH)D measured in mid-life with cognition and dementia risk in whites and blacks. Hypothesis: We hypothesized that lower concentrations of 25(OH)D would be associated cross-sectionally with lower cognitive test scores and prospectively with greater decline in cognitive test scores and with increased risk of dementia. Methods: We conducted cross-sectional (1993-1995), change (1993-1995 to 2004-2006), and prospective (follow-up through 2010) analyses of 1,652 participants in the ARIC Brain Ancillary Study with measured 25(OH)D (1993-1995). 25(OH)D was analyzed in race-specific tertiles and continuously. Cognition was measured by 3 tests: Delayed Word Recall (DWR), Digit Symbol Substitution (DSS), and Word Fluency (WF). Dementia was defined by hospitalization ICD-9 codes. Adjusted race-stratified linear regression and Cox proportional hazards models were used. Results: Mean age of participants was 62 years, 60% were female, and 48% were black. Mean 25(OH)D was higher in whites than blacks (25.5 versus 17.3 ng/ml, p&lt;0.05). Over a median of 16.6 years, there were 145 incident hospitalized dementia cases. In prospective analyses, lower levels of 25(OH)D trended towards an association with increased dementia risk in whites and in blacks, but these results were not statistically significant (lowest versus highest tertile: whites, HR: 1.32 [95% CI: 0.69, 2.55]; blacks, HR: 1.53 [95% CI: 0.84, 2.79]) (Figure). Conclusion: In contrast to prior studies performed in elderly populations, our study did not find significant associations between lower levels of 25(OH)D in mid-life with lower cognitive test scores at baseline, change in score over time, or increased dementia risk.
Screening for Cancer: Advice for High-Value Care From the American College of Physicians
Authors: Timothy J. Wilt, Russell P. Harris, Amir Qaseem
Journal: Annals of Internal Medicine (2015)

Background Cancer screening is one approach to reducing cancer-related morbidity and mortality rates. Screening strategies vary in intensity. Higher-intensity strategies are not necessarily higher value. High-value strategies provide a degree of benefits that clearly justifies the harms and costs incurred; low-value screening provides limited or no benefits to justify the harms and costs. When cancer screening leads to benefits, an optimal intensity of screening maximizes value. Some aspects of screening practices, especially overuse and underuse, are low value. Methods Screening strategies for asymptomatic, average-risk adults for 5 common types of cancer were evaluated by reviewing clinical guidelines and evidence syntheses from the American College of Physicians (ACP), U.S. Preventive Services Task Force, American Academy of Family Physicians, American Cancer Society, American Congress of Obstetricians and Gynecologists, American Gastroenterological Association, and American Urological Association. "High value" was defined as the lowest screening intensity threshold at which organizations agree about screening recommendations for each type of cancer and "low value" as agreement about not recommending overly intensive screening strategies. This information is supplemented with additional findings from randomized, controlled trials; modeling studies; and studies of costs or resource use, including information found in the National Cancer Institute's Physician Data Query and UpToDate. Conclusion The ACP provides high-value care screening advice for 5 common types of cancer; the specifics are outlined in this article. The ACP strongly encourages clinicians to adopt a cancer screening strategy that focuses on reaching all eligible persons with these high-value screening options while reducing overly intensive, low-value screening.
Abstract 20383: The Impact of Flow Measurement After Mitral Paravalvular Leak Closure and Survival
Authors: Mohammad Sarraf, Peter M Pollak, Joseph F Malouf, Vuisile T Nkomo, Allison K Cabalka, Rick A Nishimura, Charanjit S Rihal
Journal: Circulation (2014)

Introduction: Mitral paravalvular leak (PVL) occurs in 7-17% of patients after mitral valve surgery. The percutaneous closure of these defects has become a novel treatment to prevent repeat operations. Hypothesis: We hypothesize flow dynamics correlate with clinical outcomes of patients undergoing percutaneous mitral PVL closure. Methods: We retrospectively studied 148 patients who underwent percutaneous PVL closure between 2004 and 2014 at Mayo Clinic. We measured the continuous wave (CW) Doppler time velocity integral (TVI), E velocity (as a surrogate for V wave) across the mitral valve and left ventricular ejection fraction (LVEF) by transthoracic echocardiogram within 7 days before and after PVL closure. We identified patients as non-responders if there was moderate to severe residual mitral regurgitation. t-Test was used for continuous variables and Fisher exact test was used mortality. Results: Overall, the mean CW TVI was markedly reduced by PVL closure (93±14 vs. 58±5cm, p&lt;0.02). The E velocity also decreased after closure (3.1±0.4 vs. 1.9±0.1m/sec, p&lt;0.04). LVEF, however, was reduced after PVL closure (62%±2 vs. 53%±1.5, p&lt;0.02). Among non-responders (34/148 patients), there was no significant difference between the CW and E velocity before and after the procedure (CW TVI: 96±16 vs. 83+13cm, E velocity: 2.5±0.5 vs. 2.3±0.3m/sec, p=NS). The estimated 5-year mortality of patients with no or mild residual mitral regurgitation was markedly lower compared to non-responders, 43% vs 71%, p&lt;0.05. Conclusions: The flow dynamics across the mitral valve immediately after PVL closure may correlate with long term clinical outcomes. Real time assessment of flow by transesophageal echocardiogram can be used to guide the extent of PVL closure required to change the long term clinical outcomes. Further validation and prospective studies are required.
Development of a quantitative enzyme immunoassay for measurement of PAR as a pharmacodynamic biomarker of PARP activity
Authors: Robert J. Kinders, Joann Palma, Xuesong Liu, Milagros Colon-Lopez, Yan Luo, Luiz E. Rodriguez, Yan Shi, Ran Guan, Shimin Wei, Jennifer Low, Anthony Murgo, Oxana Pickerel, Shivaani Kumar, Martin Gutierrez, Larry Rubinstein, Sherry Yang, Jay Ji, Gurmeet Kaur, Ralph Parchment, Tiziano DiPaolo, Jerry Collins, Melinda Hollingshead, Joseph Tomaszewski, James Doroshow, Vincent Giranda
Journal: Clinical Cancer Research (2006)

A5   A biochemical marker for activity of a target enzyme could provide an important readout of target inhibition and be a useful parameter in determining dosing regimens of a candidate clinical agent. Our team from Abbott Pharmaceuticals and the NCI-Frederick laboratories has developed and cross-validated a quantitative immunoassay for PAR (poly ADP-ribose polymerase) to monitor activity of PARP (PAR polymerase) as a biomarker of pharmacodynamic activity of the experimental agent ABT-888, a selective inhibitor of PARP1 and PARP2. The validated assay is a two-site enzyme chemiluminescence immunoassay employing commercially-obtained antibodies to PAR, and pure PAR as a standard. Assay dynamic range is 31 to 2000 pg/ml PAR, with an LLQ of approximately 15 pg/ml PAR. The standard curve is linear throughout the range (adjusted R 2  typically better than 0.98). The assay uses High, Midrange and Low controls produced from the human melanoma line Colo 829. Specimen handling was optimized for both PBMCs and tumor needle biopsies (18 ga), and harmonized for use with the same standards and controls. Specimens could be subjected to at least 3 freeze-thaw cycles without a detectable loss of antigen binding. Assay precision was determined at both Abbott and the NCI-Frederick, to be better than 20% (estimated total imprecision at Abbott, 7% or less). Accuracy, as assessed by spike recovery of pure PAR into PBMC lysates, was 100% +/- 20%. Assay dilution linearity was established for the Colo829 controls, although deviations from linearity are observed in some tumor homogenates, and assay conditions are controlled to compensate for that lack of linearity. The validated assay was used to measure PAR levels in PBMCs of healthy donors, and in animal models after administration of a single dose of ABT-888. This assay will be used in real time to measure PAR in PBMCs and tumor biopsies in a Phase 0 clinical trial at the NCI.Funded by NCI Contract N01-CO-12400.
Early Intensification of Intrathecal Chemotherapy Virtually Eliminates Central Nervous System Relapse in Children With Acute Lymphoblastic Leukemia
Authors: Ching-Hon Pui, Hazem H. Mahmoud, Gaston K. Rivera, Michael L. Hancock, John T. Sandlund, Frederick G. Behm, David R. Head, Mary V. Relling, Raul C. Ribeiro, Jeffrey E. Rubnitz, Larry E. Kun, William E. Evans
Journal: Blood (1998)
GLI2 as a marker of hedgehog‐responsive cells
Authors: Candice Alexandra Grzelak, Nicholas David Sigglekow, Geoffrey William McCaughan
Journal: Hepatology (2014)

Potential conflict of interest: Nothing to report. To the Editor: The article by Guy et al.1 nicely illustrated improved nonalcoholic steatohepatitis (NASH) patient outcomes correlated with a decrease in Sonic Hedgehog (SHH+) cell numbers. Further, the number of GLI2+ SOX9+ liver progenitor cells also tended to decrease.1 We are excited by these data, which suggest that an association between a decrease in exposure to SHH ligand reduces the intensity of the ductular reaction. However, we would like to address the limitations of using only GLI2 as a marker of Hedgehog (Hh)‐responsive cells. The canonical Hh pathway signal is transduced following Hh ligand binding to its receptor, Patched1 (PTCH1), leading to the derepression and activation of Smoothened (SMO). The result is stabilization of GLI proteins (GLI1, GLI2, GLI3) into transcriptional activators, and Hh target gene expression. In vertebrates, transduction of Hh ligand signal into a GLI‐mediated transcriptional response occurs following SMO translocation into the primary cilium (Pc).2 This is pertinent to consider, as GLI‐mediated transcriptional responses can be driven independently of the Hh/PTCH1/Pc/SMO‐cascade.3 Therefore, although GLI expression is an indicator that cells may be canonically responding to Hh ligand, to definitively identify an Hh‐responsive cell in a panel of markers is required. This is what we have used within our own study.4 Using a combination of Pc, SMO, and GLI2 expression, we were able to confirm the importance of canonical Hh signals within the liver progenitor population (EpCAM+ Pc+ SMO+ GLI2+) in the thioacetamide mouse liver injury model. However, we also showed that there were a number of other GLI2+ cell populations including myofibroblasts, leukocytes, and hepatocytes in chronic liver injury that were Pc–.4 Furthermore, in Fig. 3E of Guy et al.,1 there seems to be widespread hepatocyte GLI2 staining posttreatment. This is highly suggestive that not all GLI‐mediated transcriptional responses are driven canonically in liver disease. Indeed, it is well recognized that SMO‐independent GLI transcription can occur by way of growth factors such as transforming growth factor beta (TGF&bgr);, EGF, HGF, and FGF in other systems,3 and the widespread hepatocyte staining in improved liver injury may represent the hepatocyte response to “repair/regenerative”‐orientated growth factors. Thus, we would encourage the use of a panel of phenotypic markers including Pc, GLI, and SMO before claiming to identify “canonical Hh‐responsive” cells in vivo.
Depressive relapses and incomplete recovery from index episode
Authors: Carlo Faravelli, Alessandra Ambonetti, Stefano Pallanti, Adolfo Pazzagli
Journal: American Journal of Psychiatry (1986)

Of 101 patients suffering from primary unipolar depression who were followed up for at least 1 year after recovery from the index episode, 51 relapsed into a new depressive episode within the year of recovery. Only those variables related to the period immediately after discharge distinguished nonrelapsers from relapsers; relapsers showed higher levels of residual symptoms, inferior social adaptation, a more pathological mean personality profile, and lower tricyclic plasma levels, despite similar dosage. The data are consistent with the hypothesis of an incomplete recovery from the index episode as a risk factor for relapse within 1 year.
HIV/STI co-infection among men who have sex with men in Spain
Authors: A Diaz, M L Junquera, V Esteban, B Martínez, I Pueyo, J Suárez, J  M Ureña, J A Varela, M Vall, J del Romero, I Sanz, J Belda, J Boronat, P Gómez, F Gual, C Colomo, J López de Munain, J Balaguer, M C Landa, M E Lezaun, M C Cámara, E Fernández, F  J Bru, I Alastrue, J R Ordoñana, C de Armas, M A Azpiri, L Gomez, J Trullén, M Diez, None on behalf of STI Study Group and EPI-VIH Group
Journal: Eurosurveillance (2009)

In Spain, neither the HIV nor the STI national surveillance systems collect information on HIV/STI co-infection. However, there are two networks based on HIV/STI clinics which gather this data. We describe HIV prevalence in men who have sex with men (MSM) diagnosed with infectious syphilis and/or gonorrhoea in 15 STI clinics; and concurrent diagnoses of STI in MSM newly diagnosed with HIV in 19 HIV/STI clinics. In total, 572 MSM were diagnosed with infectious syphilis and 580 with gonorrhoea during 2005-2007. HIV prevalence among syphilis and gonorrhoea cases was 29.8% and 15.2% respectively. In the multivariate analysis, HIV/syphilis co-infection was associated with being Latin American; having a history of STI; reporting exclusively anal intercourse; and having sex with casual or several types of partners. HIV and gonorrhoea co-infection was associated with age older than 45 years; having no education or only primary education completed; and having a history of STI. In total, 1,462 HIV infections were newly diagnosed among MSM during 2003-2007. Of these, 31.0% were diagnosed with other STI at the same time. Factors associated with STI co-infection among new HIV cases in MSM were being Latin American; and having sex with casual partners or with both steady and casual partners. In Spain, a considerable proportion of MSM are co-infected with HIV and STI.
Multiple Forms of Angiostatin Induce Apoptosis in Endothelial Cells
Authors: Rudolf Lucas, L. Holmgren, Irène Garcia, B. Jimenez, Stefano Jacopo Mandriota, F. Borlat, B. K. Sim, Z. Wu, G. E. Grau, Y. Shing, G. A. Soff, N. Bouck, Michael Sean Pepper
Journal: Blood (1998)
Reflections on Relevance: The Fields of Psychosomatics and Psychotherapy in 2006
Authors: Richard Balon
Journal: Psychotherapy and Psychosomatics (2007)

This article reviews several areas of new and interesting development in the fields of psychosomatics and psychotherapy published in the literature during 2006. These areas are: (1) cardiovascular illness and its interplay with depression; (2) risks and predisposing factors in the areas of mental illness and physical illness; (3) new developments in chronic fatigue syndrome, and (4) new or newly explored/modified (psycho)therapies, especially cognitive-behavioral therapy. In addition, an important area of conflict of interest in psychiatry in particular and in biomedical science in general is discussed, as this issue has reached prominence in the biomedical literature.