tbuckley/cabot-search huggingface dataset:
P450Deadaptation change in cardiac function of laborers engaged in physical labor at high altitude after returning to lower altitude
Authors: Q Zhou
Journal: Cardiovascular Research (2014)

Objective: To assess the effects of physical laborers on cardiac function at high altitude and changes in cardiac function after returning to lower altitude. Methods: According to symptomatic scores on acute high altitude reaction (AHAR), 96 male officers and soldiers, who rapidly entered high altitude areas (3700m), and engaged in heavy physical work for 50 day s,were be scored and graded. Serum CK-MB and LDH-1 levels, Tei index, LVEF and LVFS were measured in the 96 servicemen at the 50th day of residing at high altitude, and the 2nd and 15th day after returning to 1500m,and the results were compared with that of 50 healthy controls residing at 1500m. Results: Among the 96 male servicemen, 71 developed AHAR,a nd 24 of them had severe AHAR, 47 mild to moderate AHAR, and the rest 25 had no AHAR. Serum CK-MB,LDH-1 and Tei index were higher significantly in AHAR group than in the no AHAR group. As far as the values of LVEF and LVFS were concerned. Correlation analysis showed that levels of CK-MB and LDH-1 of persons staying at 3700m for 50 days were positively correlated with Tei index, and negatively correlated with LVEF, and also negatively correlated with LVFS. serum CK-MB, LDH-1 and Tei index at 3700m for 50 days were significantly higher than those 2 days and 15 days after returning to 1500m and those in control group. Moreover, the values of LVEF and LVFS were significantly lower than those at 2 and 15 days after returning to 1500m and those in control group (P<0.01). Conclusion: Heavy physical work at high altitude could obviously impair cardiac function. The impairment may aggravate along with increase in severity of AHAR. However, cardiac function may be improved significantly after returning to low altitude for 2 days, and recover to normal status 15 days later.
Cockroach allergen in house dust
Authors: J. H. van Wijnen, A. P. Verhoeff, D. K. F. Mulder‐Folkerts, H. J. H. Brachel, C. Schou
Journal: Allergy (1997)

The cockroach allergen (Bla g 1) content was determined in the floor dust of 46 homes with recent cockroach extermination in Amsterdam, The Netherlands. IgE antibodies to Blattella germanica , house‐dust mite, cat dander, dog dander, and a mixture of molds were determined in venous blood samples of 46 children (4‐12 years) and one of their biologic parents (24‐54 years). Specific IgE to cockroach was also determined in a sample of the general population studied in a previous case‐control study, one group ( n =20) with and three groups ( n =76) without history of cockroach infestation of the home. Cockroach allergen was detected in floor dust from 44% of the homes, with levels up to 3899 ng Bla g 1/g. Seven of the 46 adults and only one of the 46 children studied had positive RAST to cockroach. Geometric mean cockroach allergen concentrations in living room and master bedroom of sensitized adults were similar to those of nonsensitized adults. In the groups of children without a history of cockroach infestation of the home, positive RAST against cockroach was observed in 16% of the children with respiratory symptoms, in 4% of the children without respiratory symptoms, and in 48% of the children with two or more positive RAST to other allergens. Of the 18 children with positive RAST against cockroach, only one had a history of cockroach infestation of the home and 16 (89%) had also positive RAST against house‐dust mite.
APOBEC3G promotes liver metastasis in an orthotopic mouse model of colorectal cancer and predicts human hepatic metastasis
Authors: Qingqing Ding, Chun-Ju Chang, Xiaoming Xie, Weiya Xia, Jer-Yen Yang, Shao-Chun Wang, Yan Wang, Jiahong Xia, Libo Chen, Changchun Cai, Huabin Li, Chia-Jui Yen, Hsu-Ping Kuo, Dung-Fang Lee, Jingyu Lang, Longfei Huo, Xiaoyun Cheng, Yun-Ju Chen, Chia-Wei Li, Long-Bin Jeng, Jennifer L. Hsu, Long-Yuan Li, Alai Tan, Steven A. Curley, Lee M. Ellis, Raymond N. DuBois, Mien-Chie Hung
Journal: Journal of Clinical Investigation (2011)

Colorectal cancer is the second leading cause of death from cancer in the United States. Metastases in the liver, the most common metastatic site for colorectal cancer, are found in one-third of the patients who die of colorectal cancer. Currently, the genes and molecular mechanisms that are functionally critical in modulating colorectal cancer hepatic metastasis remain unclear. Here, we report our studies using functional selection in an orthotopic mouse model of colorectal cancer to identify a set of genes that play an important role in mediating colorectal cancer liver metastasis. These genes included APOBEC3G, CD133, LIPC, and S100P. Clinically, we found these genes to be highly expressed in a cohort of human hepatic metastasis and their primary colorectal tumors, suggesting that it might be possible to use these genes to predict the likelihood of hepatic metastasis. We have further revealed what we believe to be a novel mechanism in which APOBEC3G promotes colorectal cancer hepatic metastasis through inhibition of miR-29-mediated suppression of MMP2. Together, our data elucidate key factors and mechanisms involved in colorectal cancer liver metastasis, which could be potential targets for diagnosis and treatment.
Uncertain Value of Urinary Sediments in the Diagnosis of Amyloidosis
Authors: Tsuranobu Shirahama, Martha Skinner, Alan S. Cohen, Merrill D. Benson
Journal: New England Journal of Medicine (1977)

IN their article on the appearance of amyloid fibrils in the urinary sediment of a patient with amyloidosis1 Derosena, Koss and Pirani emphasized its potential clinical, diagnostic and investigative value. This study was followed by several reports2 3 4 that in effect supported this view. Contrary to these reports and to our expectation, however, our own preliminary attempts to detect amyloid-related substances in urine by immunologic methods using antiserums to amyloid protein AA (the major and unique constituent of secondary amyloid)5 had failed. We therefore conducted a systematic study for the appearance of amyloid in urine sediments and of its clinical and . . .
Continuous versus intermittent nebulized terbutaline: plasma levels and effects.
Authors: F W Moler, C E Johnson, C Van Laanen, J M Palmisano, S Z Nasr, O Akingbola
Journal: American Journal of Respiratory and Critical Care Medicine (1995)

The purpose of this investigation was to compare continuous versus intermittent nebulization of a beta 2-agonist, terbutaline, to determine whether differences exist in plasma concentrations or adverse cardiovascular effects of the drug with these two techniques for its administration. Sixteen children 6 to 16 yr of age, admitted for acute asthma, were enrolled in this randomized double-blind clinical trial. Nebulization of 16 mg of terbutaline over an 8-h period was performed either continuously or intermittently, with a dose of 4 mg given over 20 min every 2 h. The peak plasma terbutaline concentration for the intermittent nebulization treatment (INT) group (5.1 +/- 2.1 ng/ml) occurred 1 h after the fourth inhalation treatment and was similar to the peak concentration for the continuous nebulization treatment (CNT) group, which was reached at the end of the 8 h period (4.7 +/- 2.3 ng/ml). The maximum heart rate increase for the INT group (19.6 +/- 18.3 bpm) occurred 1 h after the fourth dose and was similar to the peak observed in the CNT group (19.6 +/- 19.2 bpm), which occurred after 3 h. Similar increases in systolic and decreases in diastolic pressures were observed for the INT and CNT groups. No evidence of serious adverse myocardial complications was seen in either group, as evidenced by measurements of the MB fraction of creatine phosphokinase (CPK-MB) and Holter-monitor recordings. Continuous nebulization of the terbutaline produces similar plasma concentrations and cardiovascular physiologic responses as intermittent nebulization.(ABSTRACT TRUNCATED AT 250 WORDS)
Excess granulation tissue responses associated with isotretinoin therapy
Authors: D.B. ROBERTSON, E. KUBIAK, E.C. GOMEZ
Journal: British Journal of Dermatology (1984)

Multiple polypoid projections of granulation tissue developed in two patients receiving isotretinoin for acne. Histological study of the lesions revealed increased amounts of non-sulphated acid mucopolysaccharides in the ground substance of the granulation tissue stroma. Complete resolution occurred following curettage with or without chemical cautery. The role of isotretinoin in the development of these lesions is discussed.
Coffee, tea, and plasma cholesterol: the Jerusalem Lipid Research Clinic prevalence study.
Authors: J D Kark, Y Friedlander, N A Kaufmann, Y Stein
Journal: BMJ (1985)

The association of intake of coffee and tea, assessed by 24 hour dietary recall, with plasma cholesterol and its lipoprotein fractions was studied in a sample of 1007 men and 589 women aged 35-64 resident in Jerusalem. These cross sectional data showed a significant linear association (p less than 0.001) between consumption of coffee in men and plasma cholesterol and low density lipoprotein cholesterol concentrations. Men who drank five cups of coffee or more had plasma cholesterol concentrations about 0.5 mmol/l (20 mg/100 ml) higher than non-drinkers after controlling for age, ethnicity, body mass, education, season of year, smoking, tea drinking, and dietary intake of fat and carbohydrates. In women adjusted mean plasma cholesterol concentration was 0.34 mmol/l (13 mg/100 ml) higher in coffee drinkers grouped together (p less than 0.01). The test for a linear trend was not significant. The association in both sexes was largely with the low density lipoprotein cholesterol fraction. High density lipoprotein cholesterol concentrations were somewhat increased in women who drank coffee (p less than 0.01 for a linear trend) but not in men. Tea drinking was not associated with unadjusted plasma cholesterol concentrations in either sex. Male tea drinkers, but not female, had slightly higher adjusted plasma cholesterol concentrations than non-drinkers (0.15 mmol/l (6 mg/100 ml), p = 0.04). No dose response relation was evident. In this population, characterised by a low intake of saturated fatty acids and relatively low mean plasma cholesterol concentrations, coffee drinking may be a determinant of low density lipoprotein cholesterol concentrations.
EVALUATION OF PLAQUE MORPHOLOGY BY 64-SLICE COMPUTED TOMOGRAPHIC ANGIOGRAPHY COMPARED TO INTRAVASCULAR ULTRASOUND IN NON-OCCLUSIVE SEGMENTS OF CORONARY ARTERIES
Authors: Manoj Kesarwani, Taeyoung Choi, Lily Honoris, David M. Shavelle, Matthew J. Budoff
Journal: Journal of the American College of Cardiology (2010)
Abstract 1657: Genome-wide association study of lung cancer: Variation in TP63 gene confers the risk of lung adenocarcinoma
Authors: Yataro Daigo, Yusuke Nakamura
Journal: Cancer Research (2012)

Abstract Lung cancer is the most common cause of death from cancer worldwide, and its incidence is increasing in East Asian and Western countries. Lung cancer comprises various types of histology that are often divided into two main types, non-small cell lung cancer and small cell lung cancer. Each type has different pathophysiological and clinical features, suggesting that their mechanisms of carcinogenesis differ. Adencarcinoma accounts for about 50% of all histological types of lung cancer, and its incidence is increasing in East Asian and Western countries. Because most of the current genome-wide association studies (GWAS) on lung cancer have been conducted in European populations with a full range of different histological types of lung cancer, GWAS that focus on individual histological groups with archived clinicopathological features are required. To identify genetic factors that modify the risk of lung adenocarcinoma, we conducted a genome-wide association study in a Japanese cohort, with replication in two independent studies in Japanese and Korean individuals, in a total of 2,098 lung adenocarcinoma cases and 11,048 controls. The combined analyses identified two susceptibility loci for lung adenocarcinoma: TERT (rs2736100, combined P = 2.91 × 10(-11), odds ratio (OR) = 1.27) and TP63 (rs10937405, combined P = 7.26 × 10(-12), OR = 1.31). When we analyzed the combinational combined effect of TP63 and TERT, we found that these two susceptibility genes showed a synergistic effect on the risk of lung adenocarcinoma (OR = 4.26). Fine mapping and re-sequencing of the region containing TP63 showed that a SNP (rs4488809) in intron 1 of TP63 showed the most significant association. Our results suggest that genetic variation in TP63 may influence susceptibility to lung adenocarcinoma in East Asian populations. Further functional studies are necessary to clarify the mechanisms by which TP63 influences susceptibility to lung adenocarcinoma. We will also report additional studies of TP63 on other ethnic populations as well as other histological types of lung cancer that will provide detailed information on the genetic etiology and heterogeneity of lung cancer. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 103rd Annual Meeting of the American Association for Cancer Research; 2012 Mar 31-Apr 4; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2012;72(8 Suppl):Abstract nr 1657. doi:1538-7445.AM2012-1657
Kaposi sarcoma herpesvirus–induced cellular reprogramming contributes to the lymphatic endothelial gene expression in Kaposi sarcoma
Authors: Hsei-Wei Wang, Matthew W B Trotter, Dimitrios Lagos, Dimitra Bourboulia, Stephen Henderson, Taija Mäkinen, Stephen Elliman, Adrienne M Flanagan, Kari Alitalo, Chris Boshoff
Journal: Nature Genetics (2004)
German doctors "work to rule" in protest at government plans
Authors: A. Tuffs
Journal: BMJ (2003)

Many doctors in Germany are providing only minimum care to their patients, in protest against the government's announcement that the health insurance budget for doctors will not be raised this year.

General practitioners and specialists with practices outside hospital are not officially allowed to go on strike. But since German health minister Ulla Schmidt announced that the health insurance budget for doctors would not be raised this …
Prognostic Importance of Atrial Fibrillation in Implantable Cardioverter-Defibrillator Patients
Authors: C. Jan Willem Borleffs, Johannes B. van Rees, Guido H. van Welsenes, Enno T. van der Velde, Lieselot van Erven, Jeroen J. Bax, Martin J. Schalij
Journal: Journal of the American College of Cardiology (2010)
Review: Fiber supplementation improves symptoms in the irritable bowel syndrome
Authors: Michael S. Green, Robert G. Badgett
Journal: Annals of Internal Medicine (2014)

Source Citation Moayyedi P, Quigley EM, Lacy BE, et al. The effect of fiber supplementation on irritable bowel syndrome: a systematic review and meta-analysis. Am J Gastroenterol. 2014;109:1367-74. 25070054
A New Electrocardiographic Parameter in Scleroderma Patients with and Without Pulmonary Hypertension: Tp-E/Qtc Ratıo
Authors: Uğur Nadir Karakulak, Naresh Maharjan, Elifcan Aladağ, Levent Kılıç, Ali Akdoğan, Ergün Barış Kaya, Lale Tokgözoğlu
Journal: Journal of the American College of Cardiology (2013)
THE PHYSICIAN AND WORKMEN'S COMPENSATION
Authors: HENRY H. KESSLER
Journal: JAMA (1928)

The introduction of workmen's compensation legislation in the United States, in 1911, opened up a new field for medical and surgical thought and practice. Industrial medicine and surgery were already beginning to assume an important position in the field of general medicine and surgery, requiring, however, a broader application of those general principles that were part of the equipment of the average physician and surgeon. Foreign countries that had enjoyed the benefits of the progressive legislation for many years had had ample time in which to evolve an adequate method for the adjudication of the claims that arose from industrial accidents. It was to this experience that we turned in framing our legislation, and though there were many differences in both local and national problems, the fundamental principles were sufficiently similar to make their utilization practical. On the whole, this legislation can still be said to be in its infancy
Abstract A2: The importance of metabolic heterogeneity and its consequences on tumor invasion, metastatic growth, and treatment
Authors: Mark Robertson-Tessi, Robert J. Gillies, Robert A. Gatenby, Alexander R.A. Anderson
Journal: Cancer Research (2013)

Abstract Heterogeneity of both the tumor microenvironment and cellular phenotype plays a key role in guiding tumor behavior. Metabolism acts as a central integrator to mediate cellular response to the changing environment, linking the effects of hypoxia, acidosis, proliferation and necrosis. Using a hybrid multi-scale mathematical model of tumor growth in a vascularized tissue, we investigate the selection pressures exerted by the tumor microenvironment as the cancer progresses. A key focus is the metabolism of both normal and tumor cells, and how small changes in phenotype can lead to the development of more metabolically aggressive groups of cells. Development of a glycolytic phenotype due to microenvironmental selection pressures leads to acid-mediated invasion. Results from the model suggest that these aggressive cells have a dramatic advantage as a metastatic seed, compared to less aggressive seeds from the same primary. In addition, there are significant differences in metastatic growth rate depending on the soil, suggesting that prevention or treatment of metastases in different organs may require different strategies. Application of pH buffering therapy has been shown in mouse models to slow down or prevent both primary tumor and metastatic growth. This treatment has been simulated in the model, and the results show that the effect of the treatment is highly sensitive to the timing of application. Additional results suggest that diffusible cytotoxic treatments such as chemotherapy may increase the metabolic aggressiveness of a tumor post-treatment due to the altered selection pressure caused by the drug. Chemotherapy removes the metabolic stratification of the tumor and allows more aggressive cells to grow towards blood vessels and normal tissue. A third treatment we consider is the use of anti-angiogenic therapy, which foments the development of aggressive phenotypes due to degradation of the tumor microenvironment. The model highlights the role of metabolic heterogeneity and microenvironmental selection in driving tumor invasion and metastatic development. Citation Format: Mark Robertson-Tessi, Robert J. Gillies, Robert A. Gatenby, Alexander R.A. Anderson. The importance of metabolic heterogeneity and its consequences on tumor invasion, metastatic growth, and treatment. [abstract]. In: Proceedings of the AACR Special Conference on Tumor Invasion and Metastasis; Jan 20-23, 2013; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2013;73(3 Suppl):Abstract nr A2.
226 Sphingosin 1-phosphate (S1P) induces increase in intracellular CA and nitric oxide (NO) formation, but not protein kinase B (PKB)/AKT activation in rat liver sinusoidal endothelial cells: Possible mechanisms of S1P for sinusoidal protection against ethanol-induced injury
Authors: D ZHENG, T KITAMURA, K IKEJIMA, N ENOMOTO, S YAMASHINA, S TSUKADA, K KON, Y TAKEI, N SATO
Journal: Hepatology (2003)
Long-Range Connectivity Defines Behavioral Specificity of Amygdala Neurons
Authors: Verena Senn, Steffen B.E. Wolff, Cyril Herry, François Grenier, Ingrid Ehrlich, Jan Gründemann, Jonathan P. Fadok, Christian Müller, Johannes J. Letzkus, Andreas Lüthi
Journal: Neuron (2014)
Glycemic Control and Hypoglycemia: Is the Loser the Winner?
Authors: Gail Musen, Alan M. Jacobson, Christopher M. Ryan, Patricia A. Cleary, Barbara H. Waberski, Katie Weinger, William Dahms, Meg Bayless, Nancy Silvers, Judith Harth, Neil White
Journal: Diabetes Care (2009)

The editorial by Perlmuter et al. (1) in the October 2008 issue of Diabetes Care commented on the long-term effects of severe hypoglycemia and raised concerns about our study (2), which reported that within the cohort of subjects who entered the Diabetes Control and Complications Trial (DCCT) during adolescence, there was no relationship between subsequent episodes of severe hypoglycemia and cognitive performance measured ∼20 years after study entry. Below, we outline their five major concerns and provide supporting information.

One concern of Perlmuter et al. was the exclusion of potential participants from the DCCT if they had a history of severe hypoglycemia, thus limiting generalizability. However, a history of severe hypoglycemia was not an absolute exclusion criterion for participation in the DCCT. Indeed, 24% of the 175 participants had previously experienced 1–5 episodes of severe hypoglycemia with loss of consciousness before entry …
The function of tumour necrosis factor and receptors in models of multi-organ inflammation, rheumatoid arthritis, multiple sclerosis and inflammatory bowel disease
Authors: G. Kollias, E. Douni, G. Kassiotis, D. Kontoyiannis
Journal: Annals of the Rheumatic Diseases (1999)

There is now good evidence to demonstrate that aberrations in tumour necrosis factor (TNF) production in vivo may be either pathogenic or protective and several plausible mechanisms may explain these contrasting activities. According to the classic pro-inflammatory scenario, failure to regulate the production of TNF at a site of immunological injury may lead to chronic activation of innate immune cells and to chronic inflammatory responses, which may consequently lead to organ specific inflammatory pathology and tissue damage. However, more cryptic functions of this molecule may be considered to play a significant part in the development of TNF mediated pathologies. Direct interference of TNF with the differentiation, proliferation or death of specific pathogenic cell targets may be an alternative mechanism for disease initiation or progression. In addition to these activities, there is now considerable evidence to suggest that TNF may also directly promote or down regulate the adaptive immune response. A more complete understanding of the temporal and spatial context of TNF/TNF receptor (TNF-R) function and of the molecular and cellular pathways leading to the development of TNF/TNF-R mediated pathologies is necessary to fully comprehend relevant mechanisms of disease induction and progression in humans. In this paper, the potential pathogenic mechanisms exerted by TNF and receptors in models of multi-organ inflammation, rheumatoid arthritis, multiple sclerosis and inflammatory bowel disease are discussed. Elucidating the nature and level of contribution of these mechanisms in chronic inflammation and autoimmunity may lead to better regulatory and therapeutic applications.
Detection of hypertension. Blood pressure determination in outpatient clinics of medical school-affiliated training programs
Authors: W. J. Mroczek
Journal: JAMA (1975)

We evaluated past medical records and conducted a hypertension screening program in the outpatient clinic of a university hospital, a community hospital, and a city hospital, with the aid of specially trained high school students under the direction of a cardiovascular nurse. Fifty-one percent of the adult black outpatients had elevations of arterial blood pressure; one half of these patients were aware of a history of hypertension. Analysis of the clinic records showed that many patients who had made multiple visits to the clinic had never had a blood pressure recorded in their charts. If progress is to be made in the detection of hypertension, blood pressures must be routinely determined. This should be incorporated into all clinic routines, particularly in clinics staffed by physicians-in-training.