tbuckley/cabot-search huggingface dataset:
FDA to review risks of antidepressants in adults
Authors: Jeanne Lenzer
Journal: BMJ (2004)

The US Food and Drug Administration (FDA) announced last week that it will examine whether antidepressants pose a similar risk of increased suicidal thoughts among adults as they do for children, by reanalysing data for adults.

“Our first priority with regard to the adult data is to finish our analysis of the adult completed …
Selected clinical highlights from the 2012 ERS congress in Vienna: Table 1–
Authors: Maurizio Marvisi, Felix J.F. Herth, Sebastian Ley, Venerino Poletti, Niels H. Chavannes, Martijn A. Spruit, Enrico Clini, Vincent Cottin
Journal: European Respiratory Journal (2012)

This article reviews a selection of scientific presentations at the 2012 European Respiratory Society Annual Congress in Vienna, Austria. The best abstracts from the groups of the Clinical Assembly (Clinical Problems, Rehabilitation and Chronic Care, Imaging, Interventional Pulmonology, Diffuse Parenchymal Lung Disease, and General Practice and Primary Care) are presented and discussed in the context of the most up-to-date literature. The reviewed topics especially deal with the areas of chronic obstructive pulmonary disease (acute exacerbations, comorbidities, prognosis and rehabilitation), the diagnosis and management of idiopathic pulmonary fibrosis, sarcoidosis, endobronchial techniques in emphysema, functional imaging and issues in respiratory medicine relevant for the primary care setting, including aspects related to end-of-life care and palliation.
Late Calls and Early Calls
Authors: J. Renwick
Journal: BMJ (1964)

I have in my possession a medical card, issued in 1914, the back of which makes interesting reading and, I feel, is worth quoting."The Committee require an injured person to comply with the following rules as to conduct."(a) He shall obey the instructions of the practitioner attending him." (b) He shall not conduct himself in a manner which is likely to retard his recovery." (c) He shall not make unreasonable demands upon the practitioner attending him." (d) He shall, whenever his condition permits, attend at the surgery of the practitioner attend- ing him on such days and at such hours as may be appointed by the practitioner." (e
Frieboes/Schönfeld Color Atlas of Dermatology
Authors: F. A. J. Kingery
Journal: JAMA (1967)

The great European physicians of 19th century dermatology have left us a legacy of the descriptive morphology of cutaneous disease which remains accurate today, after 100 years. Technically unable to provide adequate illustration, these men relied largely upon intricate verbal descriptions for the recording and classification of the various afflictions of the skin. Professor Kimmig and Dr. Jänner, in a complete revision of the<i>Frieboes/Schönfeld Color Atlas of Dermatology</i>, have used the photograph in the same way that their predecessors used words. The authors have collected colored prints which cover practically every facet of cutaneous medicine. To browse through this volume is a treat to the visually oriented physician, since the exquisite detail and realistic color reproduction afford a truly accurate record of the entities described. An atlas is particularly suited to the presentation of the morphology of cutaneous disease. The authors have organized their material well and have managed
DOES AGGRESSIVE STATIN THERAPY REDUCE CORONARY ATHEROSCLEROTIC PLAQUE LIPID CONTENT? RESULTS FROM: REDUCTION IN YELLOW PLAQUE BY AGGRESSIVE LIPID LOWERING THERAPY (YELLOW) TRIAL
Authors: Annapoorna Subhash Kini, Pedro Moreno, Jason Kovacic, Atul Limaye, Ziad Ali, Joseph Sweeny, Usman Baber, George Dangas, Samin Sharma
Journal: Journal of the American College of Cardiology (2012)
ACIP: Give Pertussis Vaccine During Every Pregnancy
Authors: Bridget M. Kuehn
Journal: JAMA (2012)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Oculomotor skill supports the development of object representations
Authors: Matthew Schlesinger, Dima Amso
Journal: Behavioral and Brain Sciences (2011)

Abstract Are infants' initial object representations innately specified? We examine the development of perceptual completion in infants by highlighting two issues. First, perceptual completion is supported by neural mechanisms that rely on experience with the environment. Second, we present behavioral and modeling data that demonstrate how perceptual completion can emerge as a consequence of changes in visual attention and oculomotor skill.
The contractile apparatus and mechanical properties of airway smooth muscle
Authors: S.J. Gunst, D.D. Tang
Journal: European Respiratory Journal (2000)

The functional properties of airway smooth muscle are fundamental to the properties of the airways in vivo. However, many of the distinctive characteristics of smooth muscle are not easily accounted for on the basis of molecular models developed to account for the properties of striated muscles. The specialized ultrastructural features and regulatory mechanisms present in smooth muscle are likely to form the basis for many of its characteristic properties. The molecular organization and structure of the contractile apparatus in smooth muscle is consistent with a model of force generation based on the relative sliding of adjacent actin and myosin filaments. In airway smooth muscle, actomyosin activation is initiated by the phosphorylation of the 20 kDa light chain of myosin; but there is conflicting evidence regarding the role of myosin light chain phosphorylation in tension maintenance. Tension generated by the contractile filaments is transmitted throughout the cell via a network of actin filaments anchored at dense plaques at the cell membrane, where force is transmitted to the extracellular matrix via transmembrane integrins. Proteins bound to actin and/or localized to actin filament anchorage sites may participate in regulating the shape of the smooth muscle cell and the organization of its contractile filament system. These proteins may also participate in signalling pathways that regulate the crossbridge activation and other functions of the actin cytoskeleton. The length-dependence of active force and the mechanical plasticity of airway smooth muscle may play an important role in determining airway responsiveness during lung volume changes in vivo. The molecular basis for the length-dependence of tension in smooth muscle differs from that in skeletal muscle, and may involve mechano-transduction mechanisms that modulate contractile filament activation and cytoskeletal organization in response to changes in muscle length. The reorganization of contractile filaments may also underlie the plasticity of the mechanical response of airway smooth muscle. Changes in the structural organization and signalling pathways of airway smooth muscle cells resulting form alterations in mechanical forces in the lung may be important factors in the development of pathophysiological conditions of chronic airway hyperresponsiveness.
Transient Increase in the Risk of Breast Cancer after Giving Birth
Authors: Mats Lambe, Chung-cheng Hsieh, Dimitrios Trichopoulos, Anders Ekbom, Maria Pavia, Hans-Olov Adami
Journal: New England Journal of Medicine (1994)

The effect of pregnancy on the risk of breast cancer is not clear. We tested the hypothesis that the risk of breast cancer increases transiently after pregnancy but then falls to a level below that of age-matched nulliparous women.
Fracture of the Lateral Tibia Plateau
Authors: Otto E. Aufranc
Journal: JAMA (1961)

Dr.F. W.Bora Jr.: A 58-year-old man was crossing the street when the bumper of a car struck the lateral aspect of his right leg just below the knee joint, forcing him to fall on his left side. He was brought immediately to the emergency ward of the Massachusetts General Hospital. Physical examination revealed a painful, moderately swollen right knee. He had full extension passively with flexion to 50°. Except for 10° of valgus which could be produced on valgus strain, no other instability was demonstrable in full extension. No valgus could be produced on similar testing of the left knee. No vascular or neurologic deficit was noted in the right lower extremity. X-ray films were taken which showed a fracture of the right lateral tibial condyle with depression of the joint surface (Fig. 1). The patient's general condition was good. He had had no significant diseases in his
Status epilepticus treated by intravenous infusions of thiopentone sodium.
Authors: A. S. Brown, J. M. Horton
Journal: BMJ (1967)

Status epileptkus is encountered relatively infrequently in neurosurgical practice. As would be expected, its greatest frequency is found in epileptic colonies and the realms of general practice. From time to time such patients may be referred to the anaesthetist and his advice sought. Because of the relative infrequency with which such patients are seen, treat ment is variable and not often reported. For that reason the experience of treating 117 such patients during the last 16 years is described.
Changing role of the consultant in mental handicap
Authors: D A Spencer
Journal: BMJ (1983)

produced death within an hour."Digitoxin is very rapidly absorbed, however, and peak concentrations are seen after about 30 minutes.After 130 mg digitoxin orally plasma concen- trations will approximate to the enormous concentration of 10 j1g/ml,2 which should rapidly lead to death.We have seen a patient die within one hour after 50 mg digoxin orally despite pacemaker implantation.Professor Bottiger also doubts that "Sir James Lubbock, in the mid-1930s would have been able to discover digitalis in the body tissues in a concentration of 2/10."That concentration corresponds to 2 jig/ml, which is of the same magnitude as the 10 uig/ml estimated above.The sensitivity limits for the assays of digitalis available in 1935 were 0 5-5 ,1g/ml,3 which indicates that the analy- tical gentleman would have been able to trace digitalis in the body of the old general.Dorothy Sayers's knowledge on digitalis toxicity seems to have been adequate.
The Prognostic Value of Ambulatory Blood Pressures
Authors: Dorthee Perloff
Journal: JAMA (1983)

We reviewed the course of 1,076 patients with essential hypertension whose condition had been initially evaluated with both ambulatory BP (ABP) and office BP (OBP) measurements. During the period of follow-up (mean, five years), fatal cardiovascular events occurred in 75 patients, and nonfatal events occurred in 153. Each patient was classified according to the difference between the mean observed ABP at entry and that predicted from the mean OBP at entry by means of an equation for the linear regression of ABP on OBP. Life-table analyses demonstrated a significantly greater estimated cumulative ten-year incidence of both fatal and nonfatal events among patients with higher than predicted ABPs than among those with lower than predicted ABPs. Because OBPs were comparable in the two groups, we conclude that ABP was an important determinant of clinical outcome.
Active and Passive Tetanus Immunization
Authors: L. Eckmann
Journal: New England Journal of Medicine (1964)

FORTY years after its discovery by the French veterinarian Ramon1 there are still controversial opinions and unexplored facts about the use of tetanus toxoid. Basic investigation of certain aspects is still lacking.For some of the main points a great deal of experience was gained during World War II. This experience proved the practically complete protection conferred by tetanus toxoid as well as its total harmlessness. In this paper some of the aspects still subject to controversy are discussed.Actual and Potential ImmunityI think it is agreed that the status of actual immunity is acquired a few days after . . .
The potential of mucoadhesive polymers in enhancing intestinal peptide drug absorption. III: Effects of chitosan-glutamate and carbomer on epithelial tight junctions in vitro
Authors: Gerrit Borchard, Henrik L. Lueβen, Albertus G. de Boer, J.Coos Verhoef, Claus-M. Lehr, Hans E. Junginger
Journal: Journal of Controlled Release (1996)
A CCR4 antagonist combined with vaccines induces antigen-specific CD8+ T cells and tumor immunity against self antigens
Authors: Helene Pere, Yves Montier, Jagadeesh Bayry, Francoise Quintin-Colonna, Nathalie Merillon, Estelle Dransart, Cecile Badoual, Alain Gey, Patrice Ravel, Elie Marcheteau, Frederic Batteux, Federico Sandoval, Olivier Adotevi, Christopher Chiu, Sylvie Garcia, Corinne Tanchot, Yu-Chun Lone, Luis Carlos Ferreira, Brad H. Nelson, Douglas Hanahan, Wolf Herman Fridman, Ludger Johannes, Eric Tartour
Journal: Blood (2011)
204 THE SEVERITY OF HEPATIC ISCHAEMIA-REPERFUSION INJURY IS ASSOCIATED WITH ACUTE KIDNEY INJURY FOLLOWING DONATION AFTER BRAIN DEATH LIVER TRANSPLANTATION
Authors: J.A. Leithead, M.J. Armstrong, C. Corbett, M. Andrew, C. Kothari, B.K. Gunson, P. Muiesan, J.W. Ferguson
Journal: Journal of Hepatology (2012)
Change in UK government must not mean widespread removal of GPs
Authors: Melvyn Jones
Journal: Journal of the Royal Society of Medicine (2010)

Maynard's deeply dispiriting article is effectively waving a white flag for the rollback of healthcare in the UK, for which there is no political mandate1. However, more importantly, I must contest one of the assertions that underpin his argument; that ‘nurse practitioners can provide what doctors provide’ which suggests substitution is a realistic policy. Maynard's phrase selectively quotes from complex evidence, using 30-year-old data, when contemporary systematic reviews raise concerns.2,3 The included studies were not powered to detect adverse events so do not measure safety.3 Similarly saying ‘Patients like them and they are cheaper’ is questionable; in that nurses may be costlier,4 as they have longer consultations (the prime driver of satisfaction but also costs),4 they use more investigations3 and do not reduce GP workload.5 Patients do like nurses for many aspects of their care but have a lower expectation from a nurse consultation6 and want to see a doctor when they have a medical problem.7

All this misses the point though; what patients want is continuity with their doctor, they have not voted to have that removed, presumably in Maynard's view the rhetoric of patient choice is now to be abandoned?

While nursing has a hugely important core role in primary care and nurses can and do undertake extended roles, there is no evidence that it is safe for wholesale substitution of nurses for doctors in primary care.
Adrenergic control of circulating lymphocyte subpopulations. Effects of congestive heart failure, dynamic exercise, and terbutaline treatment.
Authors: A S Maisel, K U Knowlton, P Fowler, A Rearden, M G Ziegler, H J Motulsky, P A Insel, M C Michel
Journal: Journal of Clinical Investigation (1990)

The current studies were undertaken to explore the relationship between enhanced sympathetic nervous activity and lymphocyte subset distribution in three settings: congestive heart failure, dynamic exercise, and beta-adrenergic agonist treatment. We compared the number and subset distribution of circulating lymphocytes in 36 patients with congestive heart failure and 31 age-matched control subjects. The number of circulating lymphocytes was lower in heart failure than in control. This was due to a reduction in Tsuppressor/cytotoxic and natural killer cells without significant alteration of Thelper cells. The extent of the alteration was similar in patients with idiopathic and ischemic heart failure, but the reduction was more pronounced in patients with New York Heart Association class III-IV than in class I-II. The plasma catecholamine elevation in heart failure was also independent of etiology but more pronounced in the more severely ill patients. We also assessed lymphocyte subsets after acute stimulation of sympathetic activity by dynamic exercise and after treatment with the beta-adrenergic agonist terbutaline. Dynamic exercise until exhaustion increased the number of circulating lymphocytes in healthy controls and heart failure patients in a subset-selective manner. By contrast, a 7-d treatment with terbutaline caused a reduction in the circulating number of lymphocytes in some subsets that was identical to that seen in heart failure patients. We conclude that prolonged sympathetic activity reduces the number of circulating lymphocytes by a beta-adrenergic mechanism. Such alterations might be involved in the pathophysiology of heart failure and other disease states involving increased activity of the sympathetic nervous system.
Consumption Time Is Not Prothrombin Time
Authors: Donald M. Dooley
Journal: JAMA (1964)

<h3>To the Editor:—</h3> We are very pleased that such a knowledgeable person as Dr. Udall would take such an interest in our communication. He is correct in that the term should have been "prothrombin time." The comments of Dr. Boyles are also appreciated.
Hepatic iron loading in mice increases cholesterol biosynthesis†
Authors: Ross M. Graham, Anita C. G. Chua, Kim W. Carter, Roheeth D. Delima, Daniel Johnstone, Carly E. Herbison, Martin J. Firth, Rebecca O'Leary, Elizabeth A. Milward, John K. Olynyk, Debbie Trinder
Journal: Hepatology (2010)

Iron and cholesterol are both essential metabolites in mammalian systems, and too much or too little of either can have serious clinical consequences. In addition, both have been associated with steatosis and its progression, contributing, inter alia, to an increase in hepatic oxidative stress. The interaction between iron and cholesterol is unclear, with no consistent evidence emerging with respect to changes in plasma cholesterol on the basis of iron status. We sought to clarify the role of iron in lipid metabolism by studying the effects of iron status on hepatic cholesterol synthesis in mice with differing iron status. Transcripts of seven enzymes in the cholesterol biosynthesis pathway were significantly up-regulated with increasing hepatic iron (R2 between 0.602 and 0.164), including those of the rate-limiting enzyme, 3-hydroxy-3-methylglutarate-coenzyme A reductase (Hmgcr; R2 = 0.362, P < 0.002). Hepatic cholesterol content correlated positively with hepatic iron (R2 = 0.255, P < 0.007). There was no significant relationship between plasma cholesterol and either hepatic cholesterol or iron (R2 = 0.101 and 0.014, respectively). Hepatic iron did not correlate with a number of known regulators of cholesterol synthesis, including sterol-regulatory element binding factor 2 (Srebf2; R2 = 0.015), suggesting that the increases seen in the cholesterol biosynthesis pathway are independent of Srebf2. Transcripts of genes involved in bile acid synthesis, transport, or regulation did not increase with increasing hepatic iron. Conclusion: This study suggests that hepatic iron loading increases liver cholesterol synthesis and provides a new and potentially important additional mechanism by which iron could contribute to the development of fatty liver disease or lipotoxicity. (HEPATOLOGY 2010;)
A genetic link between cold responses and flowering time through FVE in Arabidopsis thaliana
Authors: Hyoun-Joung Kim, Youbong Hyun, Jin-Young Park, Mi-Jin Park, Mi-Kyung Park, Myoung Duck Kim, Hye-Joung Kim, Mi Hyun Lee, Jihyun Moon, Ilha Lee, Jungmook Kim
Journal: Nature Genetics (2004)

Cold induces expression of a number of genes that encode proteins that enhance tolerance to freezing temperatures in plants. A cis-acting element responsive to cold and drought, the C-repeat/dehydration-responsive element (C/DRE), was identified in the Arabidopsis thaliana stress-inducible genes RD29A and COR15a and found in other cold-inducible genes in various plants. C/DRE-binding factor/DRE-binding protein (CBF/DREB) is an essential component of the cold-acclimation response, but the signaling pathways and networks are mostly unknown. Here we used targeted genetic approach to isolate A. thaliana mutants with altered cold-responsive gene expression (acg) and identify ACG1 as a negative regulator of the CBF/DREB pathway. acg1 flowered late and had elevated expression of FLOWERING LOCUS C (FLC), a repressor of flowering encoding a MADS-box protein. We showed that acg1 is a null allele of the autonomous pathway gene FVE. FVE encodes a homolog of the mammalian retinoblastoma-associated protein, a component of a histone deacetylase (HDAC) complex involved in transcriptional repression. We also showed that plants sense intermittent cold stress through FVE and delay flowering with increasing expression of FLC. Dual roles of FVE in regulating the flowering time and the cold response may have an evolutionary advantage for plants by increasing their survival rates.
Haemodialysis Cost Reduction by Artificial Kidney Storage: A Simple Effective Technique for Re-use of Coil Kidneys
Authors: R. P. Bell, J. E. Figueroa
Journal: BMJ (1970)

A simple method of storing and re-using coil dialysers was used in over 700 dialysers without serious complications but mantaining the efficiency of the dialyser. The method can reduce the expense of coil and tubing by as much as 70%, while the total cost of home or hospital dialysis can be reduced by as much as 15 to 25% even when the coil is re-used only once. Coils were re-used as many as 14 times, making the potential reduction in cost much larger. This technique deserves further evaluation in both hospital and home dialysis programmes.