tbuckley/cabot-search huggingface dataset:
THE AUTOPLASTIC TRANSPLANTATION OF TISSUES INTO THE BONE MARROW CAVITY
Authors: Maurice N. Richter, Henry L. Jaffe
Journal: The Journal of Experimental Medicine (1928)

When the thymus is autoplastically transplanted into the marrow cavity of the tibia of a guinea pig, the transplant degenerates, regenerates, and finally atrophies. The degeneration and regeneration of the thymus when so transplanted are similar to the homologous changes occurring when it is autoplastically transplanted into the abdominal wall. For comparative study the material used in previously published work on transplantation into the abdominal wall was reviewed. A difference in the final result of transplantation of thymus in these two situations is observed. In the abdominal wall the thymus regenerates and persists apparently indefinitely. Abdominal wall thymus transplants more than a year old have been observed. In the bone marrow cavity, the regeneration, which is slower and less abundant, is followed by an atrophy of the gland, and finally its complete disappearance. This atrophy is, we believe, the result of the encasement of the thymus in a bony capsule. That the genetic character of the transplanted tissue has much to do with the success of the transplantation in the marrow, is evident from the fact that some other tissues regenerate without encapsulation, even though they may finally disappear. The blood clot about the thymus which fills the rest of the curetted cavity, is quickly vascularized and replaced by regenerated cellular bone marrow and newly formed bony trabeculæ. The difference in the fate of the thymus when transplanted in the abdominal wall and in the marrow, is probably due to difference in the reciprocal relations of the thymus to the tissue in those situations. From experience gained in the transplantation of other tissues into the marrow cavity, we have learned that encapsulation of the transplant does not occur with all tissues. The reaction of the marrow to transplanted thymus is similar to its reaction to any tissue foreign to it.
Auer rods or McCrae rods?
Authors: Barbara J. Bain
Journal: American Journal of Hematology (2011)

Auer rods are rod-shaped crystalline structures derived from the primary granules of myeloid cells. They are most characteristic of acute myeloid leukemia (AML) but are observed also in high grade myelodysplastic syndromes and myelodysplastic/myeloproliferative neoplasms (refractory anaemia with excess of blasts 2 and chronic myelomonocytic leukemia 2, according to the 2008 WHO classification). These cytoplasmic inclusions are named for John Auer (1875–1948) who described and illustrated them in 19061 in a patient admitted to the Johns Hopkins Hospital under the care of William Osler. Auer acknowledged that the observations in this patient had been mentioned previously, in the preceding year, in an article by Thomas McCrae who was also acknowledged for the clinical notes he provided for Auer's paper.2, 3 McCrae in his paper had mentioned the forthcoming more detailed description by Auer.2 It has been suggested that the designation McCrae–Auer rods would be appropriate.3 Interestingly both McCrae and Auer thought that the cells in which they observed the inclusions were lymphoblasts. Auer rods are of considerable diagnostic importance since they indicate both the lineage and the neoplastic nature of the condition observed. They are of greatest diagnostic significance in acute promyelocytic leukemias. Bundles of Auer rods (‘faggot cells’) are characteristic and, although not totally specific, are strongly suggestive of this diagnosis. Auer rods are also characteristic of AML with t(8;21)q22;q22) in which condition they are unusually long (Figure) and are often located in a visible Golgi zone; the blast cells usually contains only a single rod, but occasionally two are present. Auer rods are also detectable in other subtypes of AML, including AML associated with t(6;9)(q23;q34). They can thus be a feature of both good prognosis and bad prognosis subtypes of AML.
Analysis of multiple biomarkers shows that lymphoma-associated macrophage (LAM) content is an independent predictor of survival in follicular lymphoma (FL)
Authors: Pedro Farinha, Hamid Masoudi, Brian F. Skinnider, Karey Shumansky, John J. Spinelli, Karamjit Gill, Richard Klasa, Nicolas Voss, Joseph M. Connors, Randy D. Gascoyne
Journal: Blood (2005)
Intercellular IgA deposition in patients with clinical features of subcorneal pustular dermatosis
Authors: K. Iwatsuki, S. Imaizumi, M. Takagi, M. Takigawa, H. Tagami
Journal: British Journal of Dermatology (1988)

Journal Article Intercellular IgA deposition in patients with clinical features of subcorneal pustular dermatosis Get access K. Iwatsuki, K. Iwatsuki Department of Dermatology, Hamamatsu University School of Medicine, 3600, Handa‐cho, Hamamatsu, Japan Search for other works by this author on: Oxford Academic Google Scholar S. Imaizumi, S. Imaizumi Department of Dermatology, Hamamatsu University School of Medicine, 3600, Handa‐cho, Hamamatsu, Japan Search for other works by this author on: Oxford Academic Google Scholar M. Takagi, M. Takagi Department of Dermatology, Hamamatsu University School of Medicine, 3600, Handa‐cho, Hamamatsu, Japan Search for other works by this author on: Oxford Academic Google Scholar M. Takigawa, M. Takigawa Department of Dermatology, Hamamatsu University School of Medicine, 3600, Handa‐cho, Hamamatsu, Japan Search for other works by this author on: Oxford Academic Google Scholar H. Tagami H. Tagami Department of Dermatology, Tohoku University School of Medicine, i‐i, Seiryo‐cho, Sendai, Japan Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 119, Issue 4, 1 October 1988, Pages 545–547, https://doi.org/10.1111/j.1365-2133.1988.tb03261.x Published: 01 October 1988
SIGNIFICANCE OF CARDIAC TROPONIN T LEVELS IN SUPRAVENTRICULAR TACHYCARDIA
Authors: Junji Kawagoe, Takuroh Imamura, Keishi Kubo, Sumiharu Sakamoto, Erika Nagatomo, Yunosuke Matsuura, Takeshi Ideguchi, Toshihiro Tsuruda, Hisamitsu Onitsuka, Riichiro Kawamoto, Tetsunori Ishikawa, Toshiro Nagoshi, Haruhiko Date, Kazuo Kitamura
Journal: Journal of the American College of Cardiology (2010)
AMBULANCE FOR TRANSPORTATION OF PREMATURE INFANTS
Authors: Julius H. Hess
Journal: JAMA (1928)

A most important epoch in the life of the premature infant is that period between birth and the institution of some proper method for the prevention of thermal shock. It is the experience of all institutions receiving such infants that many of them are lost through carelessness in protecting them during the first hours after birth. The electrically heated bag here illustrated is constructed to meet conditions encountered in the home and during transportation of infants from distant points by train or automobile. It is designed as a part of the obstetric department equipment for general and special hospitals or other institutions likely to be called on for the temporary care of premature infants. The hand bag is of leather and steel construction, 24 inches long, 14 inches wide and 17 inches deep. An even temperature is maintained by electric heat with thermostatic control. A composite
Neuroleptic malignant syndrome: May be caused by other drugs..
Authors: P M Haddad
Journal: BMJ (1994)

there are few published data to support these claims.In a prospective randomised trial in 140 patients that compared laparoscopic and open appendicectomy Tate et al found no significant differences between the groups in pain score, analgesic requirement, hospital stay, or time to return to work.2The only significant finding was that the operating time was nearly twice as long in the laparoscopic group.In addition, conversion to an open operation was necessary in a fifth of the patients undergoing laparoscopy.Further prospective randomised trials are needed to establish the place of laparoscopic surgery.Without such data the current enthusiasm for laparoscopic surgery may be unfounded.
The Vietnam Veterans Agent Orange Relief Act
Authors: Eric G. Comstock
Journal: JAMA (1983)

<h3>To the Editor.—</h3> The power of inappropriate mass hysteria to mold public policy is illustrated by the Vietnam Veterans Agent Orange Relief Act, S-374, currently before the first session of the 98th Congress. The bill presumes causation when a disease that could be caused by exposure to phenoxyherbicides meets certain conditions, even though there is no record of evidence of the disease during the period of service. The bill provides that "The Administrator" shall determine the diseases according to credible medical opinion and shall determine what constitutes exposure. The offering of such legislation reflects the influence of a large constituency of veterans whose concerns have been inflamed by the mass media representation of dioxin toxicity. National television has described dioxin toxicity as so great that scientists from around the world flocked to study the accidental spill of dioxin in Seveso, Italy, in 1976. There was no mention that chloracne was
Nonconceptual content and the distinction between implicit and explicit knowledge
Authors: Ingar Brinck
Journal: Behavioral and Brain Sciences (1999)

The notion of nonconceptual content in Dienes &amp; Perner's theory is examined. A subject may be in a state with nonconceptual content without having the concepts that would be used to describe the state. Nonconceptual content does not seem to be a clear-cut case of either implicit or explicit knowledge. It underlies a kind of practical knowledge, which is not reducible to procedural knowledge, but is accessible to the subject and under voluntary control.
A recurrent mutation in MED12 leading to R961W causes Opitz-Kaveggia syndrome
Authors: Hiba Risheg, John M Graham, Robin D Clark, R Curtis Rogers, John M Opitz, John B Moeschler, Andreas P Peiffer, Melanie May, Sumy M Joseph, Julie R Jones, Roger E Stevenson, Charles E Schwartz, Michael J Friez
Journal: Nature Genetics (2007)
Pregnancy, Preeclampsia, and the Endothelial Cell
Authors: Thomas F. Ferris
Journal: New England Journal of Medicine (1991)

IN 1941, Soma Weiss, in the foreword to his and Lewis Dexter's book Preeclamptic and Eclamptic Toxemia of Pregnancy, wrote, "Investigations in various branches of the natural sciences, including medicine, have shown that the study of problems which fall on the borderline between diverse specialties has yielded worthwhile results."1 Weiss and Dexter speculated that preeclampsia was an endothelial-cell disease because of the marked edema of the hands and face. A review 50 years later of the ways in which the endothelial cell might be involved in preeclampsia reaffirms the wisdom of their view that pregnancy, a condition involving problems . . .
The effect of liquid fibre on gastric emptying in the rat and humans and the distribution of small intestinal contents in the rat.
Authors: J Tomlin, N Brown, A Ellis, A Carlsson, C Bogentoft, N W Read
Journal: Gut (1993)

A combination of the polysaccharide ethyl-hydroxyethyl-cellulose (EHEC) and the surfactant sodium-dodecylsulphate (SDS) has the extraordinary physical property of being liquid at room temperature but gelling firmly at 37 degrees C. It has been named 9liquid fibre9 and its effect on gastric emptying has been tested in rats and humans, as well as its effect on intestinal distribution in rats. Rats were gavaged with 5 ml of radiolabelled liquid fibre, SDS in water, or water control. Subgroups were killed after 25, 50, 100, 200, and 300 minutes, the gut removed, and the distribution of radioactivity measured scintigraphically. Liquid fibre gelled in the stomach and spread exponentially down the small intestine before 25 minutes. This distribution was maintained for 200 minutes after which the stomach began to empty again. In the human study, 10 healthy men drank 250 ml liquid fibre and placebo labelled with 1.85 MBq technetium tin colloid on separate occasions. Gastric emptying was measured by gamma-camera. Half emptying time significantly increased from 17.7 to 55.8 minutes (means, p &lt; 0.05). The time for 10% to empty (which includes any lag time) increased from 7.0 to 19.4 minutes (p &lt; 0.05). Average emptying rate decreased from 4.49%/min for placebo to 1.60%/min for liquid fibre (p &lt; 0.01). The dramatic delay in gastric emptying suggests liquid fibre may have clinical applications while its liquid formulation should improve acceptability.
Observations on THE TREATMENT OF PLEURITIC EFFUSIONS
Authors: T. Horder
Journal: BMJ (1929)

TiHE ch,oiee of thiis subject for discussion su ggests that there imay be differences in the routine teaclhing anid p1l.tice of some of us in regard to tliis-matter, or tllat there mnay be new iniethods that requtire ventilation anid (riticinsm.In the renmarks which follow I propose to deal very largely witlh tlle priniciples whiclh guiide me personally ill practice, rather thani present a suimimiary of all the know-ai variations upon customarv procedure.It will p)rob-a1l)lv b)e foulnd that I h1avte very little to say that is novel, hut what I sayN w-ill at alny rte serve as a basis for aniy ov-elties.that mav follow-in tile course of the discussion.-(kSil'e, in the fir-st place, to stress the fact that the -.u(cc.ssfulhandlinig of a case, of pleuritic effulion does rea lly rest upo;l principles, more' ,or less clearly definiable, lnd that the appropriate treatmenit of the effusion depenids oipon a (onsideratioii of several ffaetors:1. rhe cause of the iiifection.2. The nature of the effusion.3. Its size.4. Thie stage in thle disease process at which the patient has arrived.5. Thte associated conditioni of tl-e lunig. 6.The degree of illness of the patientt; 7. The contribution made by the effusion, as suchi, to the illness.The timne-honoured division of effusions in1to scrols-, or scro-fibrinous, and puruleiit is justified both Ofl clinjical and on1 bacteriological grounids, and bringgs into close asso- ciatioli the first and second of the above-nanied factors:
Impaired Autofeedback Regulation of Hypothalamic Norepinephrine Release in Experimental Uremia
Authors: Katrin Klein, Markus Daschner, Marcel Vogel, Jun Oh, Thomas J. Feuerstein, Franz Schaefer
Journal: Journal of the American Society of Nephrology (2005)

Chronic renal failure (CRF) is associated with multiple hypothalamic dysfunctions, including reduced secretion of gonadotropin-releasing hormone (GnRH). Because GnRH release is tightly controlled by sympathetic neuronal input, a possible alteration of local noradrenergic neurotransmission in experimental CRF was evaluated. Basal, stimulated, and autoinhibited norepinephrine (NE) release was assessed in hypothalamic and hippocampal tissue slices obtained from 5/6-nephrectomized and control rats. Autoinhibition-free NE release from brain slices, prelabeled with [3H]NE and superfused with physiologic buffer, was stimulated by six electrical pulses, 100 Hz (pseudo-one-pulse stimulation). Autoinhibited NE release was induced by 90 pulses at 3 Hz. The release of tritiated NE was measured upon addition of increasing concentrations of unlabeled NE to exogenously activate the inhibitory alpha2-autoreceptor. Although neither basal nor stimulated NE release differed between the groups, significantly lower pIC50 and Imax estimates of the concentration-response curves of exogenous NE on [3H]NE release were observed in CRF rats, suggesting a diminished autoinhibition of hypothalamic noradrenergic terminals in CRF. Western blotting of tissue homogenates disclosed a significantly reduced abundance of alpha2-autoreceptor protein in hypothalamic tissue from CRF rats. These abnormalities were selectively observed in the hypothalamus, whereas noradrenergic autoinhibition seemed unaltered in the hippocampus. The results suggest a diminished autoinhibition of hypothalamic NE release in CRF. Although impaired hypothalamic NE autoinhibition does not explain reduced GnRH secretion in CRF, it may be involved in the pathogenesis of sympathetic hyperactivity associated with this condition.
Abstract 4599: Apigenin intake suppresses IGF-I signaling in an autochthonous mouse model of prostate cancer
Authors: Sanjeev Shukla, Sanjay Gupta
Journal: Cancer Research (2011)

Abstract Insulin-like growth factor-I (IGF-I) and its receptor (IR) plays an important role in prostate cancer development and progression. IGF-I binds to the IGF-IR that transduces signals to the nucleus and mitochondria primarily via the mitogen-activated protein kinase (MAPK) and PI3K/Akt pathways facilitating increased cell survival and proliferation. Agents that are capable of inhibiting IGF-signaling pathway might be useful in the prevention and/or therapy of prostate cancer. Apigenin, a common dietary flavonoid abundantly present in fruits and vegetables has shown remarkable cancer preventive and cancer therapeutic effects. The mechanisms underlying the cancer-protective effect remains elusive. We determined the role of IGF-signaling and its downstream and other associated events by apigenin using TRAMP model. TRAMP represents males spontaneously develop prostatic adenocarcinoma that progresses through multiple stages and exhibits both histological and molecular features similar to that of human prostate cancer. TRAMP males exhibit an increase in the level of serum IGF-I, uPA and VEGF; p-Akt (Ser473), p-ERK1 (T202/Y204) and p-ERK2 (T185/Y187) in the dorso-lateral prostate of TRAMP mice in age-dependent manner, compared to non-transgenic littermates. Oral intake of apigenin at 20- and 50- microg/mouse/day (gavaged in 0.2 ml vehicle containing 0.5% methyl cellulose and 0.025% Tween 20) was provided for six days per week for 20 weeks; whereas the third group received vehicle only and served as control. Apigenin intake by TRAMP mice from 8-28 weeks of age exhibited marked reduction in tumor growth with no signs of metastasis and also resulted in a significant decrease in the wet weight of dorso-lateral and ventral lobes of the prostate and genitourinary apparatus. Apigenin intake exhibited a marked dose-dependent reduction in the levels of IGF-I along with significant increase in the levels of IGFBP-3 in the serum of TRAMP mice. The modulation of IGF-I/IGFBP3 was associated with suppression of p-ERK1 (T202/Y204) and p-ERK2 (T185/Y187) and p-Akt (Ser473) levels measured in the tissue lysates from the dorso-lateral prostates of these mice. Furthermore, apigenin intake resulted in marked inhibition of the target genes regulating angiogenesis and metastasis, notably VEGF, uPA, MMP-2 and -9 in the mouse serum. Taken together, this study provides evidence that in vivo growth inhibitory effects of apigenin involve inhibition of IGF-I signaling axis in prostate cancer and further support the development of apigenin as a promising anticancer agent. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 102nd Annual Meeting of the American Association for Cancer Research; 2011 Apr 2-6; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2011;71(8 Suppl):Abstract nr 4599. doi:10.1158/1538-7445.AM2011-4599
Premature Ventricular Depolarizations during Exercise
Authors: Hugh Calkins
Journal: New England Journal of Medicine (2000)

Exercise stress testing is a well-established procedure that has been in widespread clinical use for more than 30 years.1 The great majority of exercise stress tests are performed in patients with known or suspected coronary artery disease. Exercise stress testing is also commonly performed for screening in apparently healthy persons before the initiation of an exercise program. The results can be used to establish a diagnosis of coronary artery disease, to guide anti-ischemic therapy, and also to assess prognosis. An ischemic response to stress testing is a potent predictor of future coronary events, including death, in apparently healthy persons.2, . . .
Effects of Pharmacologically Induced Hypogonadism on Mood and Behavior in Healthy Young Women
Authors: Rivka Ben Dor, Veronica L. Harsh, Paige Fortinsky, Deloris E. Koziol, David R. Rubinow, Peter J. Schmidt
Journal: American Journal of Psychiatry (2013)

Objective The relationship between depression and estrogen withdrawal remains controversial. The authors examined the effects of gonadotropin-releasing hormone agonist-induced ovarian suppression on mood, sleep, sexual function, and nighttime hot flushes. They focused on whether participating women experienced clinically significant depressive symptoms and whether specific symptoms associated with hypogonadism (nighttime hot flushes and disturbed sleep) increased susceptibility to depression. Method Participants were 72 healthy premenopausal women, ages 19–52 years, with no current or past axis I psychiatric diagnosis or gynecological or other medical illness. After 2 months of baseline screening, women received monthly injections of leuprolide acetate (3.75 mg) for 2–3 months. Outcomes were measured using the Beck Depression Inventory (BDI) and a daily rating scale measuring the severity of several affective and behavioral symptoms. Data were analyzed by repeated-measures analysis of variance using PROC MIXED (for mixed models). Results BDI scores ≥10 were reported in four of the 72 women (5.6%). Relative to baseline, induced hypogonadism was associated with significantly decreased sexual interest, disturbed sleep, and more severe nighttime hot flushes, but no significant change in any mood-related symptom score. Hot flush severity was significantly correlated with disturbed sleep. Conclusions These data demonstrate that clinically significant depressive symptoms were rare accompaniments of short-term estradiol withdrawal and induced hypogonadism in healthy premenopausal women. Additionally, neither nighttime hot flushes nor disturbed sleep were sufficient to cause depressive symptoms in hypogonadal women.
Psychogenic Pain and Psychological Variables: a Psychometric Study
Authors: Manuel Valdés, Josep Treserra, Lluisa Garcia, Joan de Pablo, Tomás de Flores
Journal: Psychotherapy and Psychosomatics (1988)

A sample of 41 women suffering from psychogenic pain according to DSM-III diagnostic criteria were psychometrically studied, in order to ascertain if they showed specific psychological traits or mechanisms. Type A behavior, extraversion, neuroticism, psychoticism and dissimulation and hostility-aggressivity traits were the psychological variables studied both in the pain sample and in a matched control group. Psychogenic pain patients were significantly more neurotic and suspicious and less physically aggressive than healthy subjects and also scored significantly higher in dissimulation, which suggests a tendency to use defense mechanisms of denial.
FACTORS RELATED TO THE GROWTH OF PSITTACOSIS VIRUS (STRAIN 6BC)
Authors: Herbert R. Morgan
Journal: The Journal of Experimental Medicine (1952)

In various amounts and mixtures, adenine, guanine, xanthine, hypoxanthine, thymine, thymidine, cytidylic acid, and an enzymatic digest of desoxyribonucleic acid all failed to influence the inhibition by sulfadiazine of the growth of psittacosis virus (6BC) in embryonated eggs. A number of purine analogues, including benzimidazole, 2,6-diaminopurine, and 8-azaguanine, inhibited the growth of psittacosis virus (6BC) in tissue cultures at concentrations which had no obvious toxic effects on the host tissues. The virus inhibitory action of 2,6-diaminopurine was reversed by addition of adenine and that of 8-azaguanine by guanine. The growth of psittacosis virus (6BC) was inhibited by the pteridine compounds 2-ammo-4-hydroxy-6-formylpteridine and xanthopterin, while other related substances had little or no inhibitory activity. Xanthine reversed the inhibitory effects of 2-amino-4-hydroxy-6-formylpteridine. There was no correlation between the inhibitory activity of the pteridines on xanthine oxidase and multiplication of the virus.
APP locus duplication causes autosomal dominant early-onset Alzheimer disease with cerebral amyloid angiopathy
Authors: Anne Rovelet-Lecrux, Didier Hannequin, Gregory Raux, Nathalie Le Meur, Annie Laquerrière, Anne Vital, Cécile Dumanchin, Sébastien Feuillette, Alexis Brice, Martine Vercelletto, Frédéric Dubas, Thierry Frebourg, Dominique Campion
Journal: Nature Genetics (2005)