Cephalothin in Serious Bacterial Infection
Authors: S L Merrill, A Davis, B Smolens, S M Finegold
Journal: Annals of Internal Medicine (1966)

Article1 January 1966Cephalothin in Serious Bacterial InfectionSTEVEN L. MERRILL, M.D., ALVIN DAVIS, M.D., BERNARD SMOLENS, M.D., SYDNEY M. FINEGOLD, M.D., F.A.C.P.STEVEN L. MERRILL, M.D.Search for more papers by this author, ALVIN DAVIS, M.D.Search for more papers by this author, BERNARD SMOLENS, M.D.Search for more papers by this author, SYDNEY M. FINEGOLD, M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-64-1-1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptCephalothin*, 7-(thiophene-2-acetamido)-cephalosporanic acid, a semisynthetic derivative of cephalosporin C, became available for clinical trial in the United States in 1962. Its history, chemistry, and early clinical use have been the subject of several recent reports (1-9).It has been shown to be effective against penicillinase-producing staphylococci, certain other gram-positive cocci, and certain gram-negative bacilli. Some workers have speculated that there would not be cross-allergenicity between cephalothin and the penicillins, and cephalothin has been administered to patients known to be allergic to penicillin G without apparent untoward effect (5, 7, 9). Skin-reactive and hemagglutinating antibody studies in animals have...References1. FLUXRILEYBRACKEN MHDEC: Treatment of 100 infants and children with cephalothin. Antimicrobial Agents and Chemotherapy. Braun-Brumfield, Ann Arbor, 1963, p. 254. Google Scholar2. HEITLERISENBERGKARELITZACSDRILLER MSHDSHM: Clinical and laboratory experience and evaluation of cephalothin in pediatric patients. Ibid., p. 261. Google Scholar3. HERRELLBALOWSBECKER WEAJ: Some experimental and clinical studies on cephalothin. Clin. Pharmacol. Ther. 4: 709, 1963. CrossrefMedlineGoogle Scholar4. PHILSONCLANCYALEXANDER JRCFJD: Cephalothin therapy in bacterial infections. Antimicrobial Agents and Chemotherapy. Braun-Brumfield, Ann Arbor, 1963, p. 267. Google Scholar5. SIDELLBURDICKBRODIEBULGERKIRBY SREJRJWM: New antistaphylococcal antibiotics. Comparative in vitro and in vivo activity of cephalothin, nafcillin, cloxacillin, oxacillin, and methicillin. Arch. Intern. Med. (Chicago) 112: 21, 1963. CrossrefMedlineGoogle Scholar6. WALTERSROMANSKYJOHNSON EWMJAC: Cephalothin—laboratory and clinical studies in 109 patients. Antimicrobial Agents and Chemotherapy. Braun-Brumfield, Ann Arbor, 1963, p. 247. Google Scholar7. GRIFFITHBLACK RSHR: Cephalothin—a new antibiotic. Preliminary clinical and laboratory studies. JAMA 189: 823, 1964. CrossrefMedlineGoogle Scholar8. 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ALLENROBERTSKIRBY JDCEWM: Staphylococcal septicemia treated with methicillin. Report of twenty-two cases. New Eng. J. Med. 266: 111, 1962. CrossrefMedlineGoogle Scholar15. SABATHPOSTICFINLAND LDBM: Methicillin treatment of severe staphylococcal disease. Observations in 146 cases. New Eng. J. Med. 267: 1049, 1962. CrossrefMedlineGoogle Scholar16. KLEINFINLAND JOM: The new penicillins. New Eng. J. Med. 269: 1019, 1074, 1129, 1963. CrossrefMedlineGoogle Scholar17. EICKHOFFKISLAKFINLAND TCJWM: Clinical evaluation of nafcillin in patients with severe staphylococcal disease. New Eng. J. Med. 272: 699, 1965. CrossrefGoogle Scholar18. ANDERSONPETERSDORF KNRG: Cephalosporin C and cephalothin in gram-negative infections. Antimicrobial Agents and Chemotherapy. Braun-Brumfield, Ann Arbor, 1962, p. 724. Google Scholar19. HOLLOWAYSCOTT WJEG: Clinical experience with cephalothin in treatment of severe infections. Antimicrobial Agents and Chemotherapy. Braun-Brumfield, Ann Arbor, 1964, p. 215. Google Scholar20. DAVISSELIGMANHEWITTFINEGOLD ASJWLSM: Neutropenic reaction to cephalothin therapy. Antimicrobial Agents and Chemotherapy. Braun-Brumfield, Ann. Arbor, 1963, p. 272. Google Scholar21. HEWITTFINEGOLDMONZON WLSMOT: Untoward side effects associated with methicillin therapy. Antimicrobial Agents and Chemotherapy. Braun-Brumfield, Ann Arbor, 1961, p. 765. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: From the Medical Service of the Wadsworth Veterans Administration Hospital and the Department of Medicine of the UCLA Center for the Health Sciences, Los Angeles, Calif.This study was supported in part by a grant from Eli Lilly and Company, Indianapolis, Ind.Portions of this study were presented before the Golden Anniversary Session of the American College of Physicians, March 23, 1965, Chicago, Ill.Requests for reprints should be addressed to Sydney M. Finegold, M.D., Wadsworth Veterans Administration Hospital, Wilshire and Sawtelle Blvds., Los Angeles, Calif. 90073*Kindly supplied by R. S. Griffith, M.D., of Eli Lilly and Company as Compound 38253, and subsequently as Keflin®. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byAntimicrobial Therapy for the Elderly PatientPenicillins and CephalosporinsStaphylococcus aureus bacteremic syndromes: Diagnostic and therapeutic updateCephalothin Induced Neutropenia during the Treatment of Bacterial EndocarditisQuantitation of Antibiotics by High-Pressure Liquid Chromatography: CephalothinImmunology of the AntibioticsBacteriological Study on Effects of Beta-Lactam Group Antibiotics in High ConcentrationsCephalothin and Cephaloridine Therapy for Bacterial Meningitis An EvaluationLARRY S. FISHER, M.D., ANTHONY W. CHOW, M.D., F.R.C.P.(C), THOMAS T. YOSHIKAWA, M.D., LUCIEN B. GUZE, M.D., F.A.C.P.The Cephalosporin Group of AntibioticsMyeloidStructural changes in the hypothalamo-hypophyseal neurosecretory system and endocrine glands produced by amphetamine in animals with experimental atherosclerosisDevelopment of Meningitis During Cephalothin TherapyRICHARD J. MANGI, M.D., RONALD S. KUNDARGI, M.B., B.S., RICHARD QUINTILIANI, M.D., VINCENT T. ANDRIOLE, M.D., F.A.C.P.Use of sodium cephalothin in the management of lung gangreneWichtige Nebenwirkungen von AntibioticaCephalosporinsThe New Penicillins and CephalosporinsAntimicrobial therapy in theory and practice. I. Clinical pharmacologyAspectos gerais das septicemias e bacteriemias estafilocócicas no adultoTreatment of Bacterial Endocarditis with CephalothinThe Cephalosporin AntibioticsTreatment of Bacterial Endocarditis in Patients with Penicillin HypersensitivityGEORGE R. GREEN, M.D., GUSTAVUS A. PETERS, M.D., F.A.C.P., JOSEPH E. GERACI, M.D., F.A.C.P.Antimicrobial therapy in patients sensitive to penicillin 1 January 1966Volume 64, Issue 1Page: 1-12KeywordsClinical chemistryClinical trialsHospital medicineMedical servicesPenicillinPneumoniaStaphylococcal infectionStaphylococcus aureusSuperinfectionsVeteran care ePublished: 1 December 2008 Issue Published: 1 January 1966 Copyright & PermissionsCopyright ©, 1966, by The American College of PhysiciansPDF downloadLoading ...