ON THE TOXICITY OF THE MERCURIAL DIURETICS: OBSERVATIONS ON EIGHTEEN CASES WITH SUGGESTIONS FOR THE PREVENTION OF TOXIC REACTIONS
Authors: S BEN-ASHER
Journal: Annals of Internal Medicine (1946)

Article1 October 1946ON THE TOXICITY OF THE MERCURIAL DIURETICS: OBSERVATIONS ON EIGHTEEN CASES WITH SUGGESTIONS FOR THE PREVENTION OF TOXIC REACTIONSSOLOMON BEN-ASHER, M.D.SOLOMON BEN-ASHER, M.D.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-25-4-711 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptSince the introduction of novarsurol as a diuretic by Saxl and Heilig1 in 1923, dehydration by means of the mercurial has played an important rôle in the treatment of congestive heart failure. Within recent years, however, instances of fatal and non-fatal reactions have been described in the literature. These reactions, though they occur infrequently, cause a great deal of apprehension when one has to resort to the use of the drug.The literature on the toxic reactions to the mercurial diuretics published prior to 1942 has been adequately reviewed by DeGraff and Nadler.2In 1944, Wexler and Ellis3reported two...Bibliography1. SAXLHEILIG PR: Ueber die diuretische Wirkung von Novarsurol und anderen Quecksilberinjektionen, Wien. klin. Wchnschr., 1920, xxxiii, 943. Google Scholar2. DEGRAFFNADLER ACJE: A review of the toxic manifestations of mercurial diuretics in man, Jr. Am. Med. Assoc., 1942, cxix, 1006. CrossrefGoogle Scholar3. WEXLERELLIS JLB: Toxic reactions to the intravenous injection of mercurial diuretics, Am. Heart Jr., 1944, xxvii, 86. CrossrefGoogle Scholar4. VOLINILEVITTMARTIN IFROR: Sudden death following mercurial diuresis, Jr. Am. Med. Assoc., 1945, cxxviii, 12. CrossrefGoogle Scholar5. BEN-ASHER S: Fatal reaction following the intravenous injection of mercupurin, Jr. Med. 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(Series 4) 1941, i, 221-226. Google Scholar20. LYONSAVERYJACOBSON RHNLSD: Effect of dehydration, produced by mercupurin, on the plasma volume of normal persons, Am. Heart Jr., 1944, xxviii, 247. CrossrefGoogle Scholar21. DEGRAFFLEHMAN ACRA: The acute toxicity of mercurial diuretics, Jr. Am. Med. Assoc., 1942, cxix, 998-1001. CrossrefGoogle Scholar22. EICHHORST H: Toxämische Delirien bei Herzkranken, Deutsch. med. Wchnschr., 1898, xxiv, 389. CrossrefGoogle Scholar23. SRNETZ K: Vorsicht mit Salyrgan bei schwerer Herzschwäche, München. med. Wchnschr., 1934, lxxxi, 1891. Google Scholar24. JOHNSTON RL: Cardiac depression by mercurial diuretics, Jr. Lab. and Clin. Med., 1941, xxix, 303-307. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Jersey City, N. J.*Received for publication December 14, 1945.From the medical departments of the Medical Center, the Fairmount Hospital, and the Greenville Hospital, Jersey City. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byQuecksilberhaltige DiureticaManaging Unmanageable EdemaEffectiveness of an Oral, Nonmercurial DiureticClinical Evaluation of a New Oral Nonmercurial DiureticTHE LONG-TERM USE OF THE ORAL DIURETIC 3-CHLORO-MERCURI-2-METHOXY-PROPYLUREA (NEOHYDRIN) IN AMBULATORY PATIENTS*JOHN M. EVANS, M.D., RASHID A. MASSUMI, M.D.MetalleMetalleEffects of mercurial diuresis in patients with ascites due to cirrhosisCONGESTIVE HEART FAILURE AND HYPONATREMIA: UNTOWARD EFFECTS OF MERCURIAL DIURESIS*DAVID CITRON, M.D., BERNARD BERCU, M.D., RICHARD LEMMER, M.D., EDWARD MASSIE, M.D., F.A.C.P.CLINICAL EXPERIENCES WITH A NEW MERCURIAL DIURETIC FOR SUBCUTANEOUS ADMINISTRATION*JOSEPH B. VANDER VEER, M.D., F.A.C.P., P. T. KUO, M.D., DAVID S. MARSHALL II, M.D.NEUTROPENIA IN A PATIENT TREATED WITH A MERCURIAL DIURETIC AND ITS RESPONSE TO BAL*CHARLES E. BENDER, M.D., ROBERT J. HOXSEY, M.D., QUIN B. DEMARSH, M.D.Pathogenesis and Treatment of Salt and Water Retention in Congestive Failure 1 October 1946Volume 25, Issue 4Page: 711-724KeywordsDiureticsDrugsHeart failureToxicity ePublished: 1 December 2008 Issue Published: 1 October 1946 PDF downloadLoading ...