tbuckley/cabot-search huggingface dataset:
Myocardial metabolic, hemodynamic, and electrocardiographic significance of reversible thallium-201 abnormalities in hypertrophic cardiomyopathy.
Authors: R O Cannon, V Dilsizian, P T O'Gara, J E Udelson, W H Schenke, A Quyyumi, L Fananapazir, R O Bonow
Journal: Circulation (1991)

BACKGROUND Exercise-induced abnormalities during thallium-201 scintigraphy that normalize at rest frequently occur in patients with hypertrophic cardiomyopathy. However, it is not known whether these abnormalities are indicative of myocardial ischemia. METHODS AND RESULTS Fifty patients with hypertrophic cardiomyopathy underwent exercise 201Tl scintigraphy and, during the same week, measurement of myocardial lactate metabolism and hemodynamics during pacing stress. Thirty-seven patients (74%) had one or more 201Tl abnormalities that completely normalized after 3 hours of rest; 26 had regional myocardial 201Tl defects, and 26 had apparent left ventricular cavity dilatation with exercise, with 15 having coexistence of these abnormal findings. Of the 37 patients with reversible 201Tl abnormalities, 27 (73%) had metabolic evidence of myocardial ischemia during rapid atrial pacing (myocardial lactate extraction of 0 mmol/l or less) compared with four of 13 patients (31%) with normal 201Tl scans (p less than 0.01). Eleven patients had apparent cavity dilatation as their only 201Tl abnormality; their mean postpacing left ventricular end-diastolic pressure was significantly higher than that of the 13 patients with normal 201Tl studies (33 +/- 5 versus 21 +/- 10 mm Hg, p less than 0.001). There was no correlation between the angiographic presence of systolic septal or epicardial coronary arterial compression and the presence or distribution of 201Tl abnormalities. Patients with ischemic ST segment responses to exercise had an 80% prevalence rate of reversible 201Tl abnormalities and a 70% prevalence rate of pacing-induced ischemia. However, 69% of patients with nonischemic ST segment responses had reversible 201Tl abnormalities, and 55% had pacing-induced ischemia. CONCLUSIONS Reversible 201Tl abnormalities during exercise stress are markers of myocardial ischemia in hypertrophic cardiomyopathy and most likely identify relatively underperfused myocardium. In contrast, ST segment changes with exercise and systolic compression of coronary arteries on angiography are unreliable markers of inducible myocardial ischemia in hypertrophic cardiomyopathy. Apparent cavity dilatation during 201Tl scintigraphy may indicate ischemia-related changes in left ventricular filling, with elevation in diastolic pressures and endocardial compression.
Mitochondrial DNA copy number and future risk of B-cell lymphoma in a nested case-control study in the prospective EPIC cohort
Authors: Fatemeh Saberi Hosnijeh, Qing Lan, Nathaniel Rothman, Chin San Liu, Wen-Ling Cheng, Alexandra Nieters, Per Guldberg, Anne Tjønneland, Daniele Campa, Alessandro Martino, Heiner Boeing, Antonia Trichopoulou, Pagona Lagiou, Dimitrios Trichopoulos, Vittorio Krogh, Rosario Tumino, Salvatore Panico, Giovanna Masala, Elisabete Weiderpass, José María Huerta Castaño, Eva Ardanaz, Núria Sala, Miren Dorronsoro, J. Ramón Quirós, María-José Sánchez, Beatrice Melin, Ann Sofie Johansson, Johan Malm, Signe Borgquist, Petra H. Peeters, H. Bas Bueno-de-Mesquita, Nick Wareham, Kay-Tee Khaw, Ruth C. Travis, Paul Brennan, Afshan Siddiq, Elio Riboli, Paolo Vineis, Roel Vermeulen
Journal: Blood (2014)
H3N2 Flu Virus Infections Increase During Fair Season
Authors: Rebecca Voelker
Journal: JAMA (2012)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
MRSA and Clostridium difficile are falling
Authors: P. A. Riley
Journal: BMJ (2010)

In their editorial on the use of co-trimoxazole as prophylaxis after percutaneous endoscopic gastrostomy, Kurien and Sanders state that the incidence of meticillin resistant Staphylococcus aureus (MRSA) and Clostridium difficile is increasing.1 In England this is …
The pattern of genetic transmission of the leukocyte defect in fatal granulomatous disease of childhood
Authors: D. B. Windhorst, A. R. Page, B. Holmes, P. G. Quie, R. A. Good
Journal: Journal of Clinical Investigation (1968)

The leukocyte-phagocytic function test which was found to be abnormal in boys with fatal granulomatous disease of childhood has been found to be abnormal to an intermediate extent in their mothers. Nine of nine mothers were shown to be abnormal, whereas none of eight fathers and none of five healthy brothers exhibited a defect. 10 of 16 female siblings were abnormal to the same degree as their mothers, as were all three maternal grandmothers available for study. Assuming that this intermediate functional defect represents the heterozygous state, the nine family pedigrees are entirely compatible with the concept that the trait is transmitted on the X-chromosome.
Benefits and Costs of Home Palliative Care Compared With Usual Care for Patients With Advanced Illness and Their Family Caregivers
Authors: Barbara Gomes, Natalia Calanzani, Irene J. Higginson
Journal: JAMA (2014)

Are home palliative care services associated with benefits to patients with advanced illness and family caregivers, and are they cost-effective?Compared with usual care, home palliative care is associated with increased odds of dying at home and fewer symptoms for patients with advanced illness. It is not associated with changes in caregiver grief. Cost-effectiveness is inconclusive.
462 PREDICTION OF LIVER CIRRHOSIS RISK BY LONG-TERM CHANGES IN SERUM LEVELS OF HBV DNA AND ALANINE AMINOTRANSFERASE
Authors: C.-F. Chen, H.-I. Yang, H.-C. Chang, C.-L. Jen, U.H. Iloeje, J. Su, C.K. Hsiao, L.-Y. Wang, S.-L. You, S.-N. Lu, W.-C. Lee, C.-J. Chen
Journal: Journal of Hepatology (2012)
Angus Henry Luscombe
Authors: F E Luscombe, H C Macdonald
Journal: BMJ (2004)

Former general practitioner Wilmslow, Cheshire (b Devon 1926; q St Bartholomew's Hospital, London, 1955), d 4 May 2004.​2004.




Figure 1




Angus was called up in 1944 and commissioned into the Gordon Highlanders. He saw active service in France in 1945 and later as a counter-terrorist officer in Palestine. Leaving the army in 1948 he entered St Bartholomew's Hospital Medical School. Joining a general practice in Wilmslow in 1958, he developed one of the first multiskilled practices in Cheshire. Active in local medical management and politics he served as vice chairman of the Macclesfield Health Authority and treasurer of the local medical committee. He retired in 1989 but continued to lecture widely. He leaves a wife, Ann, and two children.
Antimicrobial vs Placebo Prophylaxis in Noncardiac Thoracic Surgery
Authors: Richard Truesdale
Journal: JAMA (1979)

A prospective, double-blind evaluation of the efficacy and safety of prophylactic cephalosporins was done in 57 patients undergoing noncardiac thoracic surgery. Twenty-eight received cephalosporin therapy, and 29 received placebo. Overall, the incidence of postoperative infections was the same; infections developed in five (17.8%) of the 28 patients in the cephalosporin group and in five (17.2%) of the 29 patients in the placebo group. Of the five deaths attributable to infection, three occurred in patients receiving placebo and two in patients receiving cephalosporin therapy. No differences were noted in WBC counts, fever, duration of hospitalization, hypersensitivity reactions, or abnormal liver functions. However, drug fever, phlebitis, and abnormal renal function occurred more often in the patients receiving cephalosporin therapy. (<i>JAMA</i>241:1254-1256, 1979)
Germany passes new transplant law
Authors: S. Goldbeck-Wood
Journal: BMJ (1997)

The German parliament has passed a new law on human organ transplantation which for the first time recognises brain stem death as being equivalent in law to death. The law was ratified last week by an unexpectedly large majority in a free vote. It allows consent for organ removal to be given by the donor's relatives, so long as they believe this to be …
Bend it like . . . ?
Authors: Des Spence
Journal: BMJ (2008)

After my turn to be bullied, teased, and dropped in a game of British bulldog we lined up to be picked for football. Like their professional counterparts, the boy captains puffed on cigarettes as they chose the team. The ritual humiliation for the short, tall, or fat was being the last to be picked. Being tall, I was shoved into position between the twin piles of jumpers with the short and fat boys my defence. The light plastic ball seemed to be possessed and …
Anthropomorphizing the CNS: Is it what or who you know?
Authors: Michael G. Wade, Jinhua Guan
Journal: Behavioral and Brain Sciences (1996)

Abstract The target article pays insufficient attention to (1) the difficulties that arise when the term “normal” is used to describe motor skill behavior, and (2) the need to resist ascribing motor control to an intelligent central nervous system. A complex systems perspective is proposed with attractor states and periodicity identified as markers of atypical coordination and control.
Thyroid autoantibodies, preterm birth, and miscarriage
Authors: R. Negro, A. Stagnaro-Green
Journal: BMJ (2011)

The association is clear, but the effects of levothyroxine treatment are uncertain

In the linked systematic review (doi:10.1136/bmj.d2616), Thangaratinam and colleagues assess the association of thyroid autoantibodies with miscarriage and preterm birth in biochemically euthyroid women and the effect of levothyroxine treatment on pregnancy outcomes.1

An association between thyroid antibodies and miscarriage was first reported in 1990.2 The finding was serendipitous—the prospective study was originally designed to evaluate the incidence and causes of postpartum thyroiditis. As the study progressed, the unexpected number of spontaneous miscarriages in euthyroid women with thyroid antibodies prompted the researchers to assess pregnancy outcome in the 552 women who were initially screened in the first trimester. The rate of miscarriage in thyroid antibody positive women was twice that seen in thyroid antibody negative women (17.0% v 8.4%; P=0.01). The increased rate of pregnancy loss was not related to differences in maternal age, cardiolipin antibody status, pregnancy history, or concentration of thyroid stimulating hormone. Similarly, the initial discovery of a significant association between thyroid antibodies and preterm delivery seems to have been by …
Impaired Insulin Signaling in Endothelial Cells Reduces Insulin-Induced Glucose Uptake by Skeletal Muscle
Authors: Tetsuya Kubota, Naoto Kubota, Hiroki Kumagai, Shinichi Yamaguchi, Hideki Kozono, Takehiro Takahashi, Mariko Inoue, Shinsuke Itoh, Iseki Takamoto, Takayoshi Sasako, Katsuyoshi Kumagai, Tomoko Kawai, Shinji Hashimoto, Tsuneo Kobayashi, Maki Sato, Kumpei Tokuyama, Satoshi Nishimura, Masaki Tsunoda, Tomohiro Ide, Koji Murakami, Tomomi Yamazaki, Osamu Ezaki, Koichi Kawamura, Hirotake Masuda, Masao Moroi, Kaoru Sugi, Yuichi Oike, Hiroaki Shimokawa, Nobuyuki Yanagihara, Masato Tsutsui, Yasuo Terauchi, Kazuyuki Tobe, Ryozo Nagai, Katsuo Kamata, Kenji Inoue, Tatsuhiko Kodama, Kohjiro Ueki, Takashi Kadowaki
Journal: Cell Metabolism (2011)
Exome sequencing reveals novel and recurrent mutations with clinical impact in blastic plasmacytoid dendritic cell neoplasm
Authors: J Menezes, F Acquadro, M Wiseman, G Gómez-López, R N Salgado, J G Talavera-Casañas, I Buño, J V Cervera, S Montes-Moreno, J M Hernández-Rivas, R Ayala, M J Calasanz, M J Larrayoz, L F Brichs, M Gonzalez-Vicent, D G Pisano, M A Piris, S Álvarez, J C Cigudosa
Journal: Leukemia (2013)
Hospital Admission Surveillance Programs
Authors: Bruce A. Flashner
Journal: JAMA (1972)

To the Editor.—  It would seem that Dr. Schubert would do better to review his own comments regarding CHAP and publish some critical evaluations of his data rather than resent the lack of our professional integrity. The Illinois program does not utilize a prior authorization method, relies solely on nurses for coordinators, and finally, has developed its own recording and evaluation system. Furthermore, the Illinois program also includes long-term care evaluation, hospital utilization committee review, and a highly developed evaluation model, elements apparently lacking from CHAP.  More important, however, is the size and methodology of the two programs. CHAP includes a few hospitals and under 100,000 patients. The Illinois program has to deal with the logistics of more than 250 hospitals and a recipient population of close to 1 million patients.  There is no question that CHAP may have been the first program of a foundation involved in utilization review.
Intercontinental spread of OXA-48 beta-lactamase-producing Enterobacteriaceae over a 11-year period, 2001 to 2011
Authors: A Potron, L Poirel, E Rondinaud, P Nordmann
Journal: Eurosurveillance (2013)

OXA-48 beta-lactamase producers are emerging as an important threat mostly in the Mediterranean area. We report here the molecular epidemiology of a collection of OXA-48 beta-lactamase-positive enterobacterial isolates (n=107) recovered from European and north-African countries between January 2001 and December 2011. This collection included 67 Klebsiella pneumoniae, 24 Escherichia coli and 10 Enterobacter cloacae. Using the EUCAST breakpoints, ninety-eight isolates (91.6%) were of intermediate susceptibility or resistant to ertapenem, whereas 66% remained susceptible to imipenem. Seventy-five per cent of the isolates co-produced an extended-spectrum beta-lactamase, most frequently CTX-M-15 (77.5%). Susceptibility testing to non-beta-lactam antibiotics showed that colistin, tigecycline, amikacin, and fosfomycin remain active against most of the isolates. Multilocus sequence typing indicated that the most common sequence types (ST) were ST101 and ST38 for K. pneumoniae and E. coli, respectively. The bla OXA-48 gene was located on a 62 kb IncL/M plasmid in 92.5% of the isolates, indicating that a single plasmid was mainly responsible for the spread of that gene. In addition, this study identified multiple cases of importation of OXA-48 beta-lactamase producers at least in Europe, and spread of OXA-48 beta-lactamase producers giving rise to an endemic situation, at least in France.
In vitro evaluation of hepatitis B virus polymerase mutations associated with famciclovir resistance
Authors: Xiaofeng Xiong, Huiling Yang, Christopher E. Westland, Ruiming Zou, Craig S. Gibbs
Journal: Hepatology (2000)

Several mutations (V521L, P525L, L528M, T532S, and V555I) in the gene for hepatitis B virus (HBV) polymerase have been identified in HBV isolated from patients that displayed break-through viremia during famciclovir treatment. To determine whether these mutations cause phenotypic resistance to famciclovir, we compared the inhibition constants (K(i)) of penciclovir triphosphate (PCVTP, the active metabolite of famciclovir) for recombinant wild-type and mutant HBV polymerases containing these mutations. In in vitro enzymatic assays, the V555I mutation displayed the most resistance (with K(i) increased by 6.2-fold) to PCVTP. The V521L and L528M mutations showed moderately decreased sensitivity to PCVTP (K(i) increased by >3-fold). We also analyzed the cross-resistance profiles of these variants for adefovir and lamivudine, two other antiviral agents that also inhibit DNA replication by HBV polymerase. All 5 famciclovir-associated mutations were sensitive to adefovir diphosphate (ADVDP) in in vitro enzymatic assays (<2.3-fold decreased sensitivity). The V521L, L528M, and T532S mutations were also sensitive to lamivudine triphosphate (LAMTP); however, the P525L and V555I mutations displayed moderately decreased sensitivity to LAMTP in enzymatic assays (3.6-fold decreased sensitivity). The lamivudine-resistant mutations M552I, M552V, and L528M+M552V, which were previously shown to display 8- to 25-fold resistance to LAMTP, were less resistant (< or = 3.1-fold) to PCVTP.
Long-term outcome after haploidentical stem cell transplant and infusion of T cells expressing the inducible caspase 9 safety transgene
Authors: Xiaoou Zhou, Antonio Di Stasi, Siok-Keen Tey, Robert A. Krance, Caridad Martinez, Kathryn S. Leung, April G. Durett, Meng-Fen Wu, Hao Liu, Ann M. Leen, Barbara Savoldo, Yu-Feng Lin, Bambi J. Grilley, Adrian P. Gee, David M. Spencer, Cliona M. Rooney, Helen E. Heslop, Malcolm K. Brenner, Gianpietro Dotti
Journal: Blood (2014)
Long-term Changes of Serum Cholesterol with Cholesterol-altering Drugs in Patients with Coronary Heart Disease
Authors: KATHERINE M. DETRE, LAWRENCE SHAW
Journal: Circulation (1974)

In a controlled secondary prevention trial of estrogen and cholesterol-lowering drugs on 570 veterans, all of whom had had one or more episodes of acute myocardial infarction, changes in serum cholesterol were followed for at least five years. The findings included the following: 1) Estrogen, 1.25 mg daily, had no appreciable effect on cholesterol level. 2) Aluminum nicotinate, 4 g/day, resulted in a 20% reduction in cholesterol level for about 2½ years after which levels slowly rose to a level 12% below the baseline level in good adherers; poor adherers had smaller ultimate changes. 3) Dextrothyroxine, 4 mg/day, had a sustained cholesterol-lowering effect of approximately 7% throughout the study. The above values were obtained after adjusting for an underlying upward trend in all cholesterol values during the five-year observation period. 4) Discontinuation of both aluminum nicotinate and dextrothyroxine resulted in a significant rise in cholesterol within three months. 5) The 6% rise in the cholesterol level found in the control group over five years of follow-up could be attributed to aging and laboratory drift. 6) Regression toward the mean rather than pharmacological effect accounted for the greater response to treatment of patients with high initial cholesterol.
A Case of Poisoning by "Faints"
Authors: J. Swain
Journal: BMJ (1891)

Has had pain in the lumbar region for three years.A tender spot present at the level of thle iliac crest.No prominenit spinlous processes.Ilas noticed a swelling in the thigh for the last fortnighit.Present condition: Smooth and rounded swelling on the inner side of the femoral vessels.August 7th.Aspirated, 6 ounces of pus removed, cavity in- jected with 1 ounice of iodoform solution.August 21st.Aspirated, 10 ounces of pus removed, again in-
Management of Heart Failure
Authors: David W. Baker, Robert Jones, Jim Hodges, Barry M. Massie, Marvin A. Konstam, Eric A. Rose
Journal: JAMA (1994)

<h3>Objective.</h3> —This article reviews the benefits and risks of coronary artery bypass grafting and angioplasty for patients with moderate or severe left ventricular systolic dysfunction and summarizes the recommendations of the expert panel for the Agency for Health Care Policy and Research Heart Failure Guideline. <h3>Data Sources.</h3> —Data were obtained from studies published in English and referenced in MEDLINE or EMBASE between 1966 and 1993. We used the search terms<i>heart failure, congestive; congestive heart failure; heart failure; cardiac failure</i>; and<i>dilated cardiomyopathy</i>in conjunction with the terms<i>coronary artery bypass grafting</i>and<i>angioplasty</i>. <h3>Study Selection.</h3> —All cohort studies and case series that provided separate outcomes data on a subgroup of patients with a left ventricular ejection fraction less than 0.40 were reviewed. <h3>Data Extraction and Synthesis.</h3> —Studies were reviewed for inclusion and exclusion criteria, survival, and functional status measures using a standardized form. Cohort studies were assessed on eight aspects of study quality using a defined list of study flaws. <h3>Conclusion.</h3> —Coronary artery bypass grafting improves 3-year survival by approximately 30% to 50% and physical functioning by approximately one New York Heart Association class in patients with moderate to severe left ventricular dysfunction and limiting angina. However, the operative mortality ranges from 5% to 30% depending on patients' ejection fractions and comorbidity. It is not clear whether patients whose predominant symptom is heart failure rather than angina benefit from bypass surgery or how much ischemia is required to justify surgical intervention. Clinical outcomes after angioplasty have not been adequately studied to determine the relative risks and benefits compared with bypass grafting. (<i>JAMA</i>. 1994;272:1528-1534)
THE ANGIO-SEAL EVOLUTION MULTICENTER REGISTRY: THE LEARNING CURVE ASSOCIATED WITH A NEW CLOSURE DEVICE
Authors: Robert J. Applegate, Zoltan Turi, Naveen Sachdev, Abdel Ahmed, Art Szyniszewski, Malcolm Foster, Antonis Pratsos, Timothy Shapiro, Steven J. Yakubov, David M. Shavelle
Journal: Journal of the American College of Cardiology (2010)
BETA CHAIN GENE OF FIBRINOGEN MODIFIES ATHEROSCLEROSIS: BEYOND THE EFFECT ON FIBRINOGEN LEVELS
Authors: Dimitris Tousoulis, Nikolaos Papageorgiou, Maria Kozanitou, Antigoni Miliou, Charalambos Antoniades, Costas Tsioufis, George Hatzis, Paraskevopoulos Theodore, Gerasimos Siasos, Ioannis Andreou, Zoi Pallantza, Christodoulos Stefanadis
Journal: Journal of the American College of Cardiology (2011)
25 Differenciation between the anti-allergic and anti-histaminic effects of loratadine (L) and astemizole (A) by skin tests
Authors: W. Skassa-Brociek, J. O'Quigley, R. Blizard, J. Cougnard, F.B. Michel, J. Bousquet
Journal: Journal of Allergy and Clinical Immunology (1988)
Cardiac rhythm abnormalities in patients presenting with transient non-focal neurological symptoms: a diagnostic grey area?
Authors: D P de Bono, C P Warlow, N M Hyman
Journal: BMJ (1982)

Eighty-nine patients attending neurology clinics with transient non-focal neurological symptoms were studied by routine electrocardiography and 24-hour monitoring of the electrocardiography and 24-hour monitoring of the electrocardiogram. In comparison with 109 control subjects there was no significant overall excess of arrhythmias (age-adjusted odds ratio 1.7, kappa2 = 2.67) except in the subgroup of patients under the age of 30 (odds ratio 11.6, p less than 0.05). Bradyarrhythmias, but not tachyarrhythmias, were significantly more common in the patients (odds ratio 7.4, p less than 0.001),. Since patients can rarely be studied while they are having symptoms a working diagnosis must be based on a balance of probabilities: arrhythmias in young patients, or bradyarrhythmias in any patient, are likely to be clinically relevant. Ambulatory electrocardiographic monitoring contributed to the diagnosis in at least 25 of the patients, Nevertheless, the extent to which further investigations are pursued, and the form of treatment ultimately adopted, must also be influenced by the frequency and severity of the patients9 symptoms.