tbuckley/cabot-search huggingface dataset:
Dose dependence of immunological response to sublingual immunotherapy
Authors: F. Marcucci, L. Sensi, G. Di Cara, C. Incorvaia, F. Frati
Journal: Allergy (2005)

Background: Sublingual‐swallow immunotherapy (SLIT) is an accepted treatment for allergic rhinitis but its optimal dosage is scantly investigated. We studied the dose dependence of clinical efficacy and immunological response to SLIT by administering two different dosages of the same allergen in rhinitic children monosensitized to grass pollen. Methods: Seventy‐one patients with comparable age and symptoms were randomized to receive SLIT by the same grass pollen extract from Stallergénes (Antony, France), 40 of them with the 100 IR and 31 with the 300 IR extract. All patients recorded diary cards for symptoms, medications and side‐effects of the treatment, and had measurements of specific IgE and IgG4 in serum by the CAP System FEIA (Pharmacia, Uppsala, Sweden) and in nasal secretion by an in situ incubation method with the same reagents of CAP System FEIA. Results: Symptom/medication scores during the pollen season were significantly higher in patients treated with the lower dosage compared with those treated with the 300 IR dosage. Side‐effects occurred with a comparable rate (25.8% vs 27.5%) in the two groups. Serum‐specific IgE and IgG4 had no significant changes after 3 months of SLIT in both groups, while a significant seasonal increase of nasal IgE ( P = 0.015) and IgG4 ( P = 0.019) was found only in patients treated with the lower dosage. Conclusions: A rise of specific IgG4 and a blunting of seasonal increase of specific IgE in serum was repeatedly reported during subcutaneous immunotherapy (SCIT) with pollen extracts. Our findings show such blunting of specific nasal IgE along with a low symptom/medication score in patients treated with SLIT with the higher dosage, but not a concomitant rise of specific nasal IgG4. This suggests a local immunological effect of SLIT, different from systemic mechanisms of SCIT.
Pregnancy in the marfan syndrome.
Authors: P Beighton
Journal: BMJ (1982)

The early stages of many neurodegenerative diseases and age-related degeneration are characterized by neurite damage and compromised synaptic function that precede neuronal cell death. We investigated the signaling mechanisms underlying neurite degeneration using cortical neuron cultures. Inhibition of heme synthesis caused neurite damage, without neuronal death, and was mediated by reduced NMDA receptor (NMDAR) expression and phosphorylation. The signaling toward the degenerative phenotype involved suppression of the extracellular signal-regulated kinase 1/2 (ERK1/2) pathway, and electrophysiological recording showed that the neurodegeneration is accompanied by reduced NMDAR current and Ca<sup>2+</sup> influx, as well as reduced voltage-gated sodium currents, consistent with compromised neurite integrity. Rescue from the degenerative phenotype by heme replacement was dependent on restoration of NR2B subunit phosphorylation and expression of NMDAR currents with higher Ca<sup>2+</sup> permeability, consistent with triggering prosurvival ERK1/2 signaling to maintain and extend neurites. This study demonstrated a new mechanism of neurodegeneration in which impaired heme synthesis led to NMDAR signaling dysfunction, suppression of the prosurvival ERK1/2 pathway, and progressive fragmentation of neuronal projections.
Pathology of Tumours of the Oral Tissues
Authors: Daniel M. Laskin
Journal: JAMA (1965)

The combination of developing teeth, intramembranous bone formation, and mucous membranes subjected to a variety of irritants, makes the oral cavity the site of a significant number of unique pathological conditions. In this book the author has elaborated upon an important aspect of oral pathology, namely, the tumors. He approaches the subject broadly, however, so that it also includes a number of non-neoplastic oral lesions that must be considered in differential diagnosis. The material is presented in several main sections: tumors of the dental tissues, tumors of debatable dental origin, primary nondental tumors, metastatic tumors of the oral tissues, salivary gland tumors, and dysplasias of bone. The various sections are subdivided into chapters, each dealing with a particular type of tumor or related group of tumors. There is also a brief section dealing with the embryology and histology of the oral tissues for readers without any specialized knowledge of these
CerS2 Haploinsufficiency Inhibits β-Oxidation and Confers Susceptibility to Diet-Induced Steatohepatitis and Insulin Resistance
Authors: Suryaprakash Raichur, Siew Tein Wang, Puck Wee Chan, Ying Li, Jianhong Ching, Bhagirath Chaurasia, Shaillay Dogra, Miina K. Öhman, Kosuke Takeda, Shigeki Sugii, Yael Pewzner-Jung, Anthony H. Futerman, Scott A. Summers
Journal: Cell Metabolism (2014)
Cerebral Dominance: The Biological Foundations
Authors: Sidney Schulman
Journal: JAMA (1985)

This relatively small book, containing 14 chapters by recognized authorities, a good index, and ample references, fulfills the usual purpose of a published symposium—to furnish in one convenient volume an overview of the status of an area of inquiry and a key to its literature. Yet, this book is quite different from the usual. It is characterized by an exploratory, tentative tone and a diversity of material that lead one at first to wonder what precisely is the scope of cerebral dominance. Both characteristics are explained by the fact that the subject is not so much an area of investigation in the ordinary sense as it is a certain general theme, to which the historically grounded title does not do justice, although it is hard to think of another that would. The theme is this—the symmetrical halves of the forebrain, possibly in all vertebrates, are not functionally symmetrical—it makes sense,
Personal Use of Alternative Medicine Therapies by Health Science Center Faculty
Authors: Mary Ann Burg
Journal: JAMA (1998)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Alanine Aminotransferase Levels in Blood Donors
Authors: JOSEPH D. SWEENEY
Journal: Annals of Internal Medicine (1987)

Letters and Corrections1 December 1987Alanine Aminotransferase Levels in Blood DonorsJOSEPH D. SWEENEY, M.D., FRANK R. ORSINI, PH.D., JOHN E. FITZPATRICK, M.D.JOSEPH D. SWEENEY, M.D.Search for more papers by this author, FRANK R. ORSINI, PH.D.Search for more papers by this author, JOHN E. FITZPATRICK, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-107-6-945_2 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: Friedman and coworkers (1) have addressed an issue of concern to blood bankers regarding the approach to the blood donor with isolated or intermittent elevations of alanine aminotransferase (ALT). In a group of frequent plateletpheresis donors, many of whom donate over 20 times per year, we examined the records of 46 donors, each of whom had donated on at least eight occasions over a 6-month period. This group consisted of 34 men and 12 women (a total of 428 ALT measurements). For each donor we calculated a mean ALT level and found a relationship between the mean...Reference1. FRIEDMANDIENSTAGWATKINS LJE. Evaluation of blood donors with elevated serum alanine aminotransferase levels. Ann Intern Med. 1987;107:137-44. LinkGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: JOSEPH D. SWEENEY, M.D.; FRANK R. ORSINI, PH.D.; JOHN E. FITZPATRICK, M.D.Affiliations: Roswell Park Memorial Institute Buffalo, NY 14263 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byPrevalence and Consistency of ALT Elevation in Plasmapheresis Donors: Implications for the Assessment of Blood Product Infectivity 1 December 1987Volume 107, Issue 6Page: 945-945KeywordsAlanine aminotransferaseBlood banksBlood donors ePublished: 1 December 2008 Issue Published: 1 December 1987 PDF downloadLoading ...
Joseph Sripalan Williams Jaya-Ratnam
Authors: D K Selvadurai
Journal: BMJ (2002)

Former consultant in accident and emergency medicine Tameside General Hospital, Ashton-under-Lyne (b Sri Lanka 1936; q Ceylon 1967; FRCS), d 9 June 2002.

After qualifying in Colombo, Joe practised in Ceylon until 1972. He then emigrated to England, where he trained in surgery and specialised in accident and emergency medicine. He worked as a registrar in Lincoln and Leicester and as a senior registrar in Middlesbrough before taking up his consultant post in Ashton-under-Lyne. Joe was an active member of his local church, where his singing talents and natural leadership were greatly appreciated. He leaves a wife, Sajo; and two children.
Preparation of ceramic microspheres for in situ radiotherapy of deep-seated cancer
Authors: Masakasu Kawashita, Ryo Shineha, Hyun-Min Kim, Tadashi Kokubo, Yoshiaki Inoue, Norio Araki, Yasushi Nagata, Masahiro Hiraoka, Yoshiki Sawada
Journal: Biomaterials (2003)
Polycythemia Vera Among Participants of a Nuclear Weapons Test
Authors: Edward W. Webster
Journal: JAMA (1987)

To the Editor.—  The report by Caldwell et al1of excess polycythemia vera among veterans who were present at the Smoky nuclear weapons test in Nevada in 1957 notes that at least two and possibly four cases of polycythemia vera were found, whereas 0.2 cases would be expected based on the Baltimore incidence rates reported by Modan.2The preceding letter by Sobell et al suggests that 0.82 cases would be expected based on Rochester, Minn, statistics. Thus, the SMR ranges from 2.44 to 10 for the two certain cases and from 4.88 to 20 for all four cases.  The radiation doses reported by Caldwell et al averaged 271 mrem (2.71 mSv) for the two certain cases and 604 mrem (6.04 mSv) for all four cases. The doubling dose (the dose that doubles the normal incidence of a medical condition) can be readily calculated from these doses. Assuming a
Expression and immune response to hepatitis C virus core DNA-based vaccine constructs
Authors: K Tokushige, T Wakita, C Pachuk, D Moradpour, D B Weiner, V R Zurawski, J R Wands
Journal: Hepatology (1996)

Hepatitis C virus (HCV) is a major worldwide cause of acute and chronic hepatitis, cirrhosis, and hepatocellular carcinoma. The development of vaccines against HCV have been complicated by the high variability of the envelope region, and it is likely that the cellular immune responses to viral structural proteins may be important for eradicating persistent viral infection. Recently, it was reported that the injection into muscle cells of plasmids encoding viral genes resulted in the generation of strong cellular immune responses. We constructed vectors that express the highly conserved HCV core gene. In this regard, the pHCV 2–2 construct contained the entire HCV core region and pHCV 4–2 contained both the 5′ noncoding region and the core gene. Cellular expression of HCV core protein was assessed following transfection into human and murine cell lines, and higher intracellular levels of the 21–kd core protein were observed with pHCV 2–2. These HCV core DNA constructs were used to immunize BALB/c mice and produced low–level anti–HCV core humoral immune responses. To assess cytotoxic T–lymphocyte (CTL) activity generated in vivo , a cloned syngeneic SP2/O myeloma cell line constitutively expressing HCV core protein was established and inoculated into BALB/c mice to produce growth of plasmacytomas. Strong CTL activity was generated because the tumor size and weight in pHCV 2–2–immunized mice were remarkably reduced compared with mice injected with mock DNA. Spontaneous CTL activity was also exhibited by splenocytes in an in vitro cytotoxicity assay. These investigations demonstrate that plasmid constructs expressing HCV core protein generate strong CTL activity, as assessed both in vivo and in vitro , and are promising candidates as antiviral agents.
Campylobacter enteritis associated with consumption of unpasteurised milk.
Authors: D A Robinson, W J Edgar, G L Gibson, A A Matchett, L Robertson
Journal: BMJ (1979)

In October and November 1978 two outbreaks of enteritis occurred in the north of England. Symptoms lasted two to over eight days but in no case necessitated admission to hospital. Faecal specimens from most of the patients were found to contain thermophilic Campylobacter sp. Inquiry disclosed that all patients had consumed unpasteurised milk from local farms. Examination of rectal swabs from the cattle concerned and milk socks yielded strains of Campylobacter sp indistinguishable from those isolated from the patients. It was therefore concluded that, since campylobacters are not known to be excreted in milk, faecal contamination of the milk had probably occurred and had led to these outbreaks. Evidence suggests that thermophilic Campylobacter sp is an occasional contaminant of milk. So long as unpasteurised milk continues to be distributed further outbreaks will probably occur.
Echocardiographic features of patients with and without residual defects after Mustard's procedure for transposition of the great vessels.
Authors: K Thompson, G A Serwer
Journal: Circulation (1981)

The usefulness of echocardiography in evaluating patients who have undergone Mustard's pro- cedure for d-transposition of the great vessels was investigated by examining the M-mode studies and cardiac catheterization data of 20 patients at least 1 year after operation.The patients were separated into two groups using the findings at cardiac catheterization.The 12 patients in group 1 were asymptomatic, were not taking cardiac medications and were free of significant residual hemodynamic defects.Echocardiographically, left ventricular diastolic dimension (LVDD) and posterior wall size (PW) were smaller than normal in these children, whereas right ventricular diastolic dimension (RVDD) and anterior wall thickness (AW) were greater than normal.The percent fractional shortening of the left ventricle (%FS) was elevated.Systemic venous atrial-to-pulmonary venous atrial dimension ratios (SVA/PVA) fell into a narrow range regardless of patient size (mean 1.00 ± 0.06) (SD).All patients in group 1 had diastolic flutter of both atrioventricular valves and ab- normal septal motion.. Two patients had systolic flutter of the pulmonary valve and nine had systolic anterior motion of the mitral valve.The eight patients in group 2 had significant residuai defects.In all five patients with baffle obstruction of systemic venous return and in the patient with baffle obstruction of pulmonary venous return, SVA/PVA was well outside group 1 limits..RVDD was above group 1 limits in one patient with RV dysfunction andAtwo with tricuspid insufficiency.Pulmonary artery diameter, LVDD, and PW were above the respective group 1 ranges in two patients with elevated pulmonary artery pressure, while pulmonary artery diameter was below.group 1 limits in the patient with pulmonic stenosis.All group 2 patients were easily distinguishable from group 1 patients by at least one variable.Thus, while marked echocardiographic differences exist between group 1 and normal patients, patients with residual defects after the Mustard procedure can be readily identified, indicating a useful role for echocardiography in the postoperative management of patients with transposition of the great vessels.
Figures show more Americans do not have insurance
Authors: Janice Hopkins Tanne
Journal: BMJ (2004)

More Americans than ever before—45 million—lack health insurance, and more are now living in poverty, show figures from the US Census Bureau last week.

The data, which are based on a comparison between 2002 and 2003, show that for the first time since 1995 women's average income fell and also that the ratio of women's earnings to men's earnings fell. And the number of people living below the poverty level in the United States (based on an annual income of $18 810 (£10 500; €15 600) or less for a family of four) increased from 34.6 million to 35.9 million.

The …
Prognostic Value of PET Myocardial Perfusion Imaging in Obese Patients
Authors: Benjamin J.W. Chow, Sharmila Dorbala, Marcelo F. Di Carli, Michael E. Merhige, Brent A. Williams, Emir Veledar, James K. Min, Michael J. Pencina, Yeung Yam, Li Chen, Sai Priya Anand, Terrence D. Ruddy, Daniel S. Berman, Leslee J. Shaw, Rob S. Beanlands
Journal: JACC. Cardiovascular imaging (2014)
Experimental strategies for research on multiple chemical sensitivity.
Authors: B Weiss
Journal: Environmental Health Perspectives (1997)

Skepticism about the validity of the multiple chemical sensitivity (MCS) syndrome stems in part from the lack of supporting experimental data. Performing the relevant experiments requires investigators to take account of broad variations in sensitivity and the need to establish reproducibility. The research approach best suited for MCS studies is the single-subject design. In contrast with conventional group designs, such designs emphasize repeated observations on individual subjects. Repeated observations of this kind constitute a time series in which successive measurements are serially or autocorrelated. One statistical method that bypasses the serial correlation problem is randomization tests. Explicit time series analyses take account of this aspect and can correct for it to determine the impact of an intervention such as a chemical exposure.
T cell source of type 1 cytokines determines illness patterns in respiratory syncytial virus-infected mice.
Authors: Y W Tang, B S Graham
Journal: Journal of Clinical Investigation (1997)

Manipulation of the cytokine microenvironment at the time of vaccination can influence immune responses to remote challenge, providing a strategy to study the molecular pathogenesis of respiratory syncytial virus (RSV) vaccine-enhanced disease in the mouse model. Although treatment with antibody against IL-4 or recombinant IL-12 (rIL-12) at the time of formalin-inactivated RSV vaccination induced a similar shift in the pattern of cytokine mRNA expression upon live virus challenge, anti-IL-4 treated mice had increased CD8+ cytotoxic T lymphocyte activity and reduced illness compared with rIL-12-treated mice. To define effector mechanisms responsible for these patterns, CD4+ and/or CD8+ T lymphocytes were selectively depleted in vivo at the time of RSV challenge. In rIL-12-treated mice, CD4+ lymphocytes made the largest contribution to IFN-gamma mRNA, RSV clearance, and illness, while in anti-IL-4 treated mice, CD8+ lymphocytes were the major effector. The effector responsible for virus clearance also mediated illness, suggesting that efficiency of virus clearance determined disease expression. These results demonstrate that the phenotype of effector cells involved in the immune response to virus challenge may be a more important determinant of disease than patterns of cytokine expression classically assigned to Th1 and Th2 lymphocytes.
Left and Right Ventricular Filling Pressures in Clinical Shock.
Authors: Jay N. Cohn
Journal: Annals of Internal Medicine (1968)

s1 May 1968Left and Right Ventricular Filling Pressures in Clinical Shock.Jay N. Cohn, M.D., F.A.C.P., Ibrahim M. Khatri, M.D., Felix E. Tristani, M.D.Jay N. Cohn, M.D., F.A.C.P., Ibrahim M. Khatri, M.D., Felix E. Tristani, M.D.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-68-5-1153_1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptCentral venous pressure is used clinically as an index of myocardial function in shock, but the relationship between right and left heart filling pressures in this situation has not been analyzed. Simultaneous measurements of right atrial (RAP) and left ventricular end diastolic (LVEDP) pressures were performed at the bedside of 18 patients with shock (9, acute myocardial infarction; 6, sepsis; 2, pulmonary embolism; 1, hepatic failure).In acute myocardial infarction LVEDP ranged from 14 to 30 mm Hg (average, 21 mm Hg) and was always at least twice the RAP (range, 3 to 14 mm Hg, average, 8.7 mm Hg).... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Washington, D. C. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByLeft Ventricular Function in Acute Myocardial Infarction and its Clinical SignificanceLeft ventricular failure in acute myocardial infarctionHypovolemia in Shock Due to Acute Myocardial Infarction 1 May 1968Volume 68, Issue 5Page: 1153-1153KeywordsAcute myocardial infarctionHeartPatient advocacyPulmonary embolismSepsisShock Issue Published: 1 May 1968 PDF DownloadLoading ...
Adoptive immunotherapy with engineered T cells expressing and HLA-A2 restricted affinity-enhanced TCR for LAGE-1 and NY-ESO-1 in patients with multiple myeloma following auto-SCT
Authors: Aaron P Rapoport, Edward A Stadtmauer, Dan T Vogl, Brendan Weiss, Gwendolyn K Binder-Scholl, Dominic P Smethurst, Jeffrey Finklestein, Irina Kulikovskaya, Minnal Gupta, Joanna E Brewer, Alan D Bennett, Andrew B Gerry, Nick J Pumphrey, Helen K Tayton-Martin, Lilliam Ribeiro, Ashraf Z Badros, Saul Yanovich, Gorgun Akpek, Naseem Kerr, Sunita Philip, Sandra Westphal, Levine L Bruce, Bent K Jakobsen, Carl H June, Michael Kalos
Journal: Journal for ImmunoTherapy of Cancer (2013)

Meeting abstracts We report on a 26 patient phase I/II clinical trial ([NCT01352286][1]) to investigate the safety, feasibility and anti-tumor activity of T cells engineered to express an affinity-enhanced TCR that recognizes the NY-ESO-1/LAGE-1 peptide complex HLA-A*0201-SLLMWITQC. Patients with
Elderly patients; their medical care before and after operation.
Authors: W. Gordon
Journal: JAMA (1963)

<b>Geriatric surgical emergencies.</b>By John E. Jesseph and Henry N. Harkins. 447 p. $16. Little, Brown &amp; Co., 34 Beacon St, Boston 6, 1963 Most important in the diagnosis of abnormality is awareness that it may be present. Kenneth Hazell, an English consultant gerontologist, constantly reminds the reader of the physiological derangements likely to be present in the elderly. Many are not obvious, but can be revealed frequently by meticulous clinical examination and certain laboratory investigations. Since functional reserve in the older patient is small or unpredictable, every effort should be made to restore normal conditions before an operation and, by close observation, to diagnose any postoperative complication very soon after its onset. How to attain these objects is told clearly and precisely in Hazell's practical book. The sections on the kidney are particularly valuable. <i>Geriatric Surgical Emergencies</i>is a more comprehensive book, written by several contributors. Physiological disturbances and