Correlation of Hepatitis C Virus Antibodies with Viremia
Authors: Heinz-Hubert Feucht
Journal: Annals of Internal Medicine (1997)

Letters15 April 1997Correlation of Hepatitis C Virus Antibodies with ViremiaHeinz-Hubert Feucht, MD, Bernhard Zollner, MD, and Rainer Laufs, MDHeinz-Hubert Feucht, MDUniversitats-Krankenhaus Eppendorf, 20246 Hamburg, GermanySearch for more papers by this author, Bernhard Zollner, MDUniversitats-Krankenhaus Eppendorf, 20246 Hamburg, GermanySearch for more papers by this author, and Rainer Laufs, MDUniversitats-Krankenhaus Eppendorf, 20246 Hamburg, GermanySearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-126-8-199704150-00031 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:Until now, it has been unclear how many patients with hepatitis C virus (HCV) antibodies have viremia and are thus infectious and how frequently spontaneous HCV elimination occurs [1-3]. In a retrospective study, we investigated serum samples of 2815 inpatients and outpatients with suspected liver disease from whom samples were obtained every 3 or 6 months for at least 2 years. Patients who received interferon therapy or were immunocompromised by other diseases were excluded. Serum samples were evaluated by HCV serologic testing and polymerase chain reaction (PCR) assay [4]. For serologic testing, HCV second-generation enzyme immunoassays were ...References1. Young KK, Archer JJ, Yokosuka O, Omata M, Resnick RM. Detection of hepatitis C virus RNA by a combined reverse transcription PCR assay: comparison with nested amplification and antibody testing. J Clin Microbiol. 1995; 33:654-7. Google Scholar2. Agnello V. Eradication of hepatitis C virus after interferon-α therapy [Letter]. Ann Intern Med. 1995; 122:474. Google Scholar3. Meisel H, Reip A, Faltus B, Lu M, Porst H, Wiese M, et al. Transmission of hepatitis C virus to children and husbands by women infected with contaminated anti-D immunoglobulin. Lancet. 1995; 345:1209-11. Google Scholar4. Feucht HH, Zollner B, Laufs R. Comparison of conventional autoradiography with a new DNA enzyme immunoassay for the detection of hepatitis C virus-polymerase chain reaction amplification products. J Virol Methods. 1995; 55:105-10. Google Scholar5. Feucht HH, Zollner B, Polywka S, Laufs R. Study on reliability of commercially available hepatitis C virus antibody tests. J Clin Microbiol. 1995; 33:620-4. Google Scholar Author, Article, and Disclosure InformationAffiliations: Universitats-Krankenhaus Eppendorf, 20246 Hamburg, Germany PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byStrategies for reliable diagnosis of hepatitis C infection: The need for a serological confirmatory assayHepatitis C, E, F, G, and Non-A-GSerological Determination of Hepatitis C Virus Subtypes 1a, 1b, 2a, 2b, 3a, and 4a by a Recombinant Immunoblot AssayGB virus C/hepatitis G virus infection in hemodialysis patients: Determination of seroprevalence by a four-antigen recombinant immunoblot assay 15 April 1997Volume 126, Issue 8Page: 666-667KeywordsAntibodiesHepatitis C virusInpatientsInterferonsLiver diseasesOutpatientsPolymerase chain reactionResearch laboratoriesRetrospective studiesViremia Issue Published: 15 April 1997 Copyright & PermissionsCopyright © 1997 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...