THE PATHOGENESIS OF LEPTOSPIRAL JAUNDICE
Authors: F. Ramos-Morales, R. S. Díaz-Rivera, A. A. Cintrón-Rivera, José A. Rullán, A. S. Benenson, Josefina Acosta-Matienzo
Journal: Annals of Internal Medicine (1959)

Article1 November 1959THE PATHOGENESIS OF LEPTOSPIRAL JAUNDICEF. RAMOS-MORALES, M.D., R. S. DÍAZ-RIVERA, M.D., F.A.C.P., A. A. CINTRÓN-RIVERA, M.D., JOSÉ A. RULLÁN, M.D., A. S. BENENSON, JOSEFINA ACOSTA-MATIENZO, M.S.F. RAMOS-MORALES, M.D.Search for more papers by this author, R. S. DÍAZ-RIVERA, M.D., F.A.C.P.Search for more papers by this author, A. A. CINTRÓN-RIVERA, M.D.Search for more papers by this author, JOSÉ A. RULLÁN, M.D.Search for more papers by this author, A. S. BENENSONSearch for more papers by this author, JOSEFINA ACOSTA-MATIENZO, M.S.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-51-5-861 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptAlthough the pathogenesis of jaundice in leptospirosis (Weil's disease) has been the subject of a great deal of speculation, it has been most frequently attributed to hemolysis and intrahepatic biliary obstruction. Many textbooks either tacitly avoid the subject or conclude, reflecting the general opinion, that the exact pathogenesis of jaundice in this disease is unknown.1The scarce material in the American medical literature does not reflect the complete clinical picture of the disease, since most of the patients studied presented intense jaundice and were severely ill.2-4Medical reports from Europe, frequently based on a large number of cases, lack laboratory...Bibliography1. Harrison TR (a) : Principles of internal medicine, 1954, The Blakiston Co., New York. (b) Strong, R. P.: Stitt's diagnosis, prevention and treatment of tropical diseases, 1944, The Blakiston Co., Philadelphia. Google Scholar2. Bertucci EA: Leptospirosis, Am. J. M. Sc. 209: 86, 1945. CrossrefGoogle Scholar3. AshePratt-ThomasKumpe WFHRCW: Weil's disease, Medicine 20: 145, 1941. CrossrefGoogle Scholar4. Senekjie HA: The clinical manifestations of leptospirosis in Louisiana, J. A. M. A. 126: 5, 1944. CrossrefGoogle Scholar5. 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Wintrobe MM: Clinical hematology, 1956, Lea and Febiger, Philadelphia. Google Scholar29. Wells RS: Observation on the blood sucking activities of the hookworm, A. caninum , J. Parasitol. 17: 167, 1931. CrossrefGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: San Juan,*Received for publication September 12, 1958.From the Department of Medicine, the Clinical Research Laboratory of the University of Puerto Rico School of Medicine, the San Juan City Hospital, and the Tropical Research Laboratory, U. S. Army, San Juan, Puerto Rico. This work was supported in part by Contract No. DA-49-007-MD-493, Office of the Surgeon General, Department of the Army, Washington, D. C.†Director, Division of Immunology, Walter Reed Institute of Research, Washington, D. C.Requests for reprints should be addressed to Francisco Ramos-Morales, M.D., Department of Medicine, School of Medicine, San Juan,Puerto Rico. 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