tbuckley/cabot-search huggingface dataset:
Abstract 2585: Resveratrol induces autophagy in prostate cancer cells and intervention suppresses the progression of PIN in animals
Authors: Guiming Li, Rita Ghosh, Paul Rivas, Robert Lee Reddick, Addanki Pratap Kumar
Journal: Cancer Research (2012)

Abstract Resveratrol (3,4′-trihydroxystilbene), a natural product is present in significant concentrations in red wine, peanuts, walnuts etc. Emerging evidence indicates that resveratrol exerts antitumorigenic activity in various tumor models including prostate. Although multiple biological effects on proliferation, apoptosis and activation of SIRT1 have been demonstrated to be associated with resveratrol-induced activities, the precise mechanism associated with resveratrol-induced SIRT1 activation and cancer cell growth inhibition remains unclear. In addition, whether resveratrol intervention suppresses the development and progression of PIN (Prostatic Intraepithelial Neoplasia) is unknown. In this study, we examined the role of SIRT1 and the underlying mechanism involved in resveratrol-mediated biological effects. Our results show that although resveratrol significantly inhibited proliferation of multiple prostate cell lines including RWPE-1, C42B, PC3 and DU145 at higher concentrations (&amp;gt; 50 µM); however, at lower concentrations (&amp;lt; 25 µM), resveratrol prompted cell proliferation. Interestingly androgen responsive LNCaP cells exhibited resistance to resveratrol-mediated inhibition of cell proliferation. Under these experimental conditions, we also observed significant increase in autophagy without remarkable increase in apoptosis. Given the role of Akt/mTOR signaling pathway as a negative regulator of autophagy, we investigated whether resveratrol induce autophagy via modulation of Akt/mTOR signaling. Our data indicate that resveratrol-induced autophagy was associated with decreased levels of mTORC1 activity and increased SIRT1 expression. Knockdown of SIRT1 enhanced prostate cell proliferation and attenuated resveratrol-induced autophagy. Using prostate specific PTEN−/− mice, we found that dietary administration of resveratrol reduced the incidence of high-grade PIN lesions significantly. These findings implicated an important role for mTORC1/SIRT1 signaling axis in mediating resveratrol-induced upregulation of autophagy and inhibition of apoptosis. [Supported by NIH CA137578 (APK)] Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 103rd Annual Meeting of the American Association for Cancer Research; 2012 Mar 31-Apr 4; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2012;72(8 Suppl):Abstract nr 2585. doi:1538-7445.AM2012-2585
Clinical Tetanus Despite a 'Protective' Level of Toxin-Neutralizing Antibody
Authors: Edward L. Passen
Journal: JAMA (1986)

TETANUS is a preventable disease. Although immunization guidelines<sup>1</sup>are generally very effective, tetanus has occurred in patients with prior immunization.<sup>2</sup>In most cases it was presumed that levels of toxin-neutralizing antibody were low. Although data on the protective level of neutralizing antibody in humans are extremely limited, animal data have been used to support the belief that 0.01 antitoxin unit/mL is protective.<sup>3,4</sup>This report describes a patient with a wound, followed by severe generalized tetanus, who was found at the onset of symptoms to have a neutralizing antibody level 16 times that considered protective. <h3>Report of a Case</h3> A 35-year-old man sustained a puncture wound in the plantar surface of his left foot. He was seen at a community hospital 35 hours later for increasing foot pain. There was no evidence of infection, and he was treated with tetanus toxoid, dicloxacillin, and acetaminophen. Approximately 38 hours after the
Suspected myocardial infarction and the GP
Authors: P Herbert
Journal: BMJ (1994)

Two papers in this week's journal amply demonstrate the failure of many general practitioners to follow the recommendations of the British Heart Foundation's working group on managing patients with myocardial infarction. Why do doctors and other health workers repeatedly fail to carry out what is widely understood to be best practice even when the scientific evidence is solid and guidelines have been established?1 Is it that doctors value their clinical freedom too much or that you cannot teach old dogs new tricks? Impassioned defences of clinical freedom, however, often mask dangerous and inefficient practice. Management based on findings from epidemiological studies and clinical trials is surely …
Intensive Respiratory Care Unit
Authors: Thomas L. Petty
Journal: JAMA (1975)

In ten years' experience in the respiratory care units serving both medical and surgical patients, 18,077 consecutive patients received ventilatory support for 24 hours or more. The overall survival rate including all patients was 75.2%. Survival rate has not changed appreciably during the past five years. The respiratory care unit provides technical assistance and consultation to primary physicians of the medical and surgical services. This system of intensive respiratory care is flexible and applicable to general hospitals that treat large numbers of patients with acute respiratory failure. (<i>JAMA</i>233:34-37, 1975)
Patient Satisfaction and Quality of Life in Psoriasis and Psoriatic Arthritis
Authors: Katherine M. Mercy, Kenneth B. Gordon, Amy S. Paller
Journal: JAMA (2014)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Comparing Severity and Outcomes for Seasonal and 2009 H1N1 Infections
Authors: Amesh A. Adalja
Journal: JAMA (2011)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Computerized Croupiers: The Las Vegas Lesson
Authors: Samuel Bigg
Journal: JAMA (1967)

<h3>To the Editor:—</h3> Will the diagnostic computer and the automatic electronic drug dispenser, interposing themselves between doctor and patient, upset the delicate doctor-patient relationship? Worse still, will they render the physician altogether obsolete? These and similar questions came to my mind, when at the clinical meeting in Las Vegas, I overheard croupiers bemoan the decimation in their ranks wrought by the recently introduced electronic blackjack devices. These veterans of the gaming tables made no secret of their fears, or of their unhappiness about the deteriorating croupier-player relationship. They felt that the machines took all the warmth out of the intimate dealer-sucker rapport. Should we not, perhaps, meet more often in Las Vegas to discuss our common problems with the worthier of the casinos?
The Effects of a Smoking Cessation Intervention on 14.5-Year Mortality
Authors: Milan C. Mathew
Journal: Annals of Internal Medicine (2005)

Letters18 October 2005The Effects of a Smoking Cessation Intervention on 14.5-Year MortalityMilan C. Mathew, MD, MPHMilan C. Mathew, MD, MPHFrom Memorial Hospital of Rhode Island and Brown University, Pawtucket, RI 02860.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-143-8-200510180-00017 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:I read with great interest the article by Anthonisen and colleagues (1) regarding the effects of a smoking cessation intervention on 14.5-year mortality in the Lung Health Study. The authors concluded that “smoking cessation intervention programs can have a substantial effect on subsequent mortality, even when successful in a minority of participants,” although the generalizability of the results was potentially limited to heavy smokers with preexisting airway obstruction. Mortality rates in the usual care group and the special intervention group did not differ significantly between participants with similar smoking habits. Therefore, the decrease in mortality is attributable ...Reference1. Anthonisen NR, Skeans MA, Wise RA, Manfreda J, Kanner RE, Connett JE, et al. The effects of a smoking cessation intervention on 14.5-year mortality: a randomized clinical trial. Ann Intern Med. 2005;142:233-9. [PMID: 15710956] LinkGoogle Scholar Author, Article, and Disclosure InformationAuthors: Milan C. Mathew, MD, MPHAffiliations: From Memorial Hospital of Rhode Island and Brown University, Pawtucket, RI 02860.Disclosures: None disclosed. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoThe Effects of a Smoking Cessation Intervention on 14.5-Year Mortality Nicholas R. Anthonisen , Melissa A. Skeans , Robert A. Wise , Jure Manfreda , Richard E. Kanner , and John E. Connett , for the Lung Health Study Research Group*The Effects of a Smoking Cessation Intervention on 14.5-Year Mortality Gregory J. Bombassei The Effects of a Smoking Cessation Intervention on 14.5-Year Mortality Nicholas R. Anthonisen Metrics 18 October 2005Volume 143, Issue 8Page: 614-615KeywordsConflicts of interestDeath ratesLungsNicotineSmoking habits ePublished: 18 October 2005 Issue Published: 18 October 2005 Copyright & PermissionsCopyright © 2005 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
INTERLEUKIN-1 BLOCKADE WITH ANAKINRA TO PREVENT ADVERSE CARDIAC REMODELING FOLLOWING ACUTE MYOCARDIAL INFARCTION: RESULTS OF THE VCU-ART2 PILOT STUDY
Authors: Antonio Abbate, Benjamin van Tassell, Giuseppe Biondi-Zoccai, Michael Kontos, John Grizzard, Claudia Oddi, Debra Spillman, Charlotte Roberts, Ryan Melchior, Nayef Abouzaki, George Mueller, Lenore Rosemary Rengel, Amit Varma, Michael Gambill, Raquel Appa Falcao, Norbert Voelkel, Charles Dinarello, George Vetrovec
Journal: Journal of the American College of Cardiology (2013)
Elevated Cytosolic Na <sup>+</sup> Decreases Mitochondrial Ca <sup>2+</sup> Uptake During Excitation-Contraction Coupling and Impairs Energetic Adaptation in Cardiac Myocytes
Authors: Christoph Maack, Sonia Cortassa, Miguel A. Aon, Anand N. Ganesan, Ting Liu, Brian O’Rourke
Journal: Circulation Research (2006)

Mitochondrial Ca 2+ ([Ca 2+ ] m ) regulates oxidative phosphorylation and thus contributes to energy supply and demand matching in cardiac myocytes. Mitochondria take up Ca 2+ via the Ca 2+ uniporter (MCU) and extrude it through the mitochondrial Na + /Ca 2+ exchanger (mNCE). It is controversial whether mitochondria take up Ca 2+ rapidly, on a beat-to-beat basis, or slowly, by temporally integrating cytosolic Ca 2+ ([Ca 2+ ] c ) transients. Furthermore, although mitochondrial Ca 2+ efflux is governed by mNCE, it is unknown whether elevated intracellular Na + ([Na + ] i ) affects mitochondrial Ca 2+ uptake and bioenergetics. To monitor [Ca 2+ ] m , mitochondria of guinea pig cardiac myocytes were loaded with rhod-2–acetoxymethyl ester (rhod-2 AM), and [Ca 2+ ] c was monitored with indo-1 after dialyzing rhod-2 out of the cytoplasm. [Ca 2+ ] c transients, elicited by voltage-clamp depolarizations, were accompanied by fast [Ca 2+ ] m transients, whose amplitude (Δ) correlated linearly with Δ[Ca 2+ ] c . Under β-adrenergic stimulation, [Ca 2+ ] m decay was ≈2.5-fold slower than that of [Ca 2+ ] c , leading to diastolic accumulation of [Ca 2+ ] m when amplitude or frequency of Δ[Ca 2+ ] c increased. The MCU blocker Ru360 reduced Δ[Ca 2+ ] m and increased Δ[Ca 2+ ] c , whereas the mNCE inhibitor CGP-37157 potentiated diastolic [Ca 2+ ] m accumulation. Elevating [Na + ] i from 5 to 15 mmol/L accelerated mitochondrial Ca 2+ decay, thus decreasing systolic and diastolic [Ca 2+ ] m . In response to gradual or abrupt changes of workload, reduced nicotinamide-adenine dinucleotide (NADH) levels were maintained at 5 mmol/L [Na + ] i , but at 15 mmol/L, the NADH pool was partially oxidized. The results indicate that (1) mitochondria take up Ca 2+ rapidly and contribute to fast buffering during a [Ca 2+ ] c transient; and (2) elevated [Na + ] i impairs mitochondrial Ca 2+ uptake, with consequent effects on energy supply and demand matching. The latter effect may have implications for cardiac diseases with elevated [Na + ] i .
Measure, Promote, and Reward Mobility to Prevent Falls in Older Patients
Authors: Samir K. Sinha, Allan S. Detsky
Journal: JAMA (2012)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The confusing case of NRG-1
Authors: S. D. Brandt, H. R. Sumnall, F. Measham, J. Cole
Journal: BMJ (2010)

Since the recent ban on mephedrone,1 2several alternative products have been introduced on internet websites. One of the most prominently discussed second generation products is Energy 1 (NRG-1), also advertised as naphyrone (naphthylpyrovalerone, O-2482), which originated from a group of compounds previously described in the medicinal chemistry …
CHEMISTRY OF THE THYROID GLAND
Authors: EDWARD C. KENDALL
Journal: JAMA (1924)

In 1895, Baumann discovered that iodin is a normal constituent of the thyroid gland. Ever since this discovery, the chemistry of the gland has centered around the iodin-containing compound. No compound isolated from the gland and not containing iodin has been shown to have physiologic activity similar to that of desiccated thyroid. The proteins of the gland have been fractioned by Oswald and others, and a globulin has been obtained which Oswald named thyreoglobulin. The iodin content of this product is slightly higher than that of the desiccated thyroid, and clinicians and physiologists agree that thyreoglobulin possesses the entire activity of the thyroid. Iodothyrin was obtained by Baumann by destroying the proteins with 10 per cent. sulphuric acid. A mixture of substances was obtained which contained about 9 per cent. of iodin, and while relieving hypothyroidism under some conditions, iodothyrin has not been regarded as the pure active constituent of
The distribution of calcium salt precipitates in the core, periphery and shell of cholesterol, black pigment and brown pigment gallstones
Authors: Howard S. Kaufman, Thomas H. Magnuson, Henry A. Pitt, Peter Frasca, Keith D. Lillemoe
Journal: Hepatology (1994)

Calcium bilirubinate, palmitate, carbonate and phosphate have been identified in the cores of cholesterol and pigment gallstones, suggesting a role for precipitated calcium salts in the early events of gallstone formation. Previous studies that compared the calcium salt contents of cholesterol and pigment stones required destruction of gallstone structure. We have used scanning electron microscopy with windowless energy-dispersive x-ray microanalysis to determine the prevalence of calcium salts in a series of cholesterol (n = 105), black pigment (n = 35) and brown pigment (n = 6) gallstones obtained from 146 consecutive patients undergoing cholecystectomy. These techniques provide specific identification of cholesterol and individual calcium salts as they occur within the core, periphery and shell of gallstones without destroying stone structure. Calcium precipitates more than 0.5 micron in diameter can be detected in a cholesterol background at a detection limit of 0.01% by weight. Calcium salts were detected in the centers of 88% of cholesterol and 100% of black (p < 0.05 vs. cholesterol) and brown pigment stones. Calcium bilirubinate was identified in the cores of 54% of cholesterol and in all pigment stones (p < 0.001 black pigment vs. cholesterol). Calcium palmitate was detected in all brown pigment stones, in 39% of cholesterol stones (p < 0.001 vs. brown pigment) and in 31% of black stones (p < 0.01 vs. brown pigment). Peripheral calcium salts were detected less in cholesterol (19%) than in black or brown stones (100%, p < 0.05). Fourteen percent of cholesterol and black pigment stones were surrounded by shells containing mostly calcium carbonate.(ABSTRACT TRUNCATED AT 250 WORDS)
Endogenous Tissue Factor Pathway Inhibitor Modulates Thrombus Formation in an In Vivo Model of Rabbit Carotid Artery Stenosis and Endothelial Injury
Authors: Massimo Ragni, Paolo Golino, Plinio Cirillo, Annalisa Scognamiglio, Orlando Piro, Nicolino Esposito, Carmine Battaglia, Filomena Botticella, Paola Ponticelli, Luigi Ramunno, Massimo Chiariello
Journal: Circulation (2000)

Tissue factor pathway inhibitor (TFPI) is the sole known inhibitor of the extrinsic coagulation pathway of physiological importance; however, its role in modulating thrombosis in vivo is still unclear.Intravascular thrombosis was initiated by placing an external constrictor around endothelially injured rabbit carotid arteries (n=10). Carotid blood flow velocity was measured by a Doppler flow probe. After placement of the constrictor, cyclic flow reductions (CFRs), due to recurrent thrombosis, developed at the site of stenosis. Transstenotic TFPI plasma activity was measured in blood samples before induction of CFRs and after 30, 60, and 180 minutes of CFRs. TFPI plasma activity distal to the site of thrombosis was significantly lower than the corresponding proximal values at 30, 60, and 180 minutes of CFRs. In addition, a progressive decrease in TFPI plasma activity was observed in both the proximal and the distal samples, indicating consumption of TFPI during thrombus formation. In 10 additional rabbits, CFRs were abolished by administration of aspirin (10 mg/kg). In the animals in which aspirin abolished CFRs, endogenous TFPI was depleted by a bolus of a polyclonal antibody against rabbit TFPI, and the effects on restoration of CFRs were monitored. In 5 of 6 animals in which aspirin abolished CFRs, depletion of endogenous TFPI activity caused full restoration of CFRs.The data of the present study support the involvement of endogenous TFPI in the process of thrombus formation in vivo and its active role in modulating arterial thrombosis.
Cap polyposis--an unusual cause of diarrhoea.
Authors: A P Campbell, C A Cobb, R W Chapman, M Kettlewell, P Hoang, B J Haot, D P Jewell
Journal: Gut (1993)

9Cap polyposis9 is a poorly recognised condition with distinct clinical, sigmoidoscopic, and pathological features that may be confused with other inflammatory conditions of the large intestine including pseudomembranous colitis and idiopathic chronic inflammatory bowel disease. The pathogenesis is unknown but on the basis of the characteristic histological appearances, which are similar to those seen in situations where mucosal prolapse is the underlying mechanism, it has been suggested that the latter may be an important aetiological factor. Two cases are described. Histological features in the first (presence of intramucosal elastin) and clinical features in the second (rectal prolapse) support the above hypothesis.
ACNE FROM IODIZED SALT
Authors: Bedford Shelmire
Journal: JAMA (1928)

Iodides and bromides have long been known to cause acneform eruptions in persons susceptible to these salts. The appearance of acne in a patient past the age of 25 immediately evokes from the dermatologist an interrogation concerning the use of these drugs. The more meticulous physician will also question his patients regarding the ingestion of iron and cod liver oil; the excessive use of cold creams and other oily cosmetics; their occupations (tar, oils, paraffin, chlorine), and the presence of diseased teeth and tonsils. In this day of fads, he should also inquire as to the ingestion of medicine taken for the prevention or treatment of goiter, such as chocolate tablets containing organic iodine, compound solution of iodine, pepto-iodine, calcidin and the many other proprietary "sure cures" for goiter. Several errors in diagnosis will prompt me, in the future, also to question my acne patients concerning the
Toward the answer, but still far to go
Authors: Toru Shimizu
Journal: Behavioral and Brain Sciences (2003)

The target article about the origin and evolution of the isocortex triggers questions about unresolved issues that still need to be dealt with, including: (1) the evolutionary scenario of the origin of the lateral isocortex, (2) the expansion of the dorsal pallium in nonmammals, and (3) the heterogeneity of the anterior dorsal ventricular ridge.