Family Occurrences of Ulcerative Colitis, Regional Enteritis, and Ileocolitis
Authors: JOSEPH B. KIRSNER
Journal: Annals of Internal Medicine (1963)

Article1 August 1963Family Occurrences of Ulcerative Colitis, Regional Enteritis, and IleocolitisJOSEPH B. KIRSNER, M.D., F.A.C.P., JEAN A. SPENCER, M.D.JOSEPH B. KIRSNER, M.D., F.A.C.P., JEAN A. SPENCER, M.D.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-59-2-133 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptDespite the genetic heterogeneity of man, surveys of disease among population groups and families are important in the search for possible etiologic mechanisms in obscure diseases. Whereas ulcerative colitis and regional enteritis hitherto had been regarded as characteristically limited to one member of a family, recent observations suggest a more than casual family incidence of these diseases.Spriggs (1) in 1934, noted ulcerative colitis in 2 brothers and a sister. Moltke (2) recorded 5 families with multiple instances of the disease (mother, daughter, 2; brother, sister, 2; and father, daughter, one). Jackman and Bargen (3) in 1942, described occurrences in...References1. SPRIGGS EI: Chronic ulceration of the colon. Quart. J. Med. 27: 549, 1934. CrossrefGoogle Scholar2a. MOLTKE O: Familial occurrences of non-specific suppurative coloproctitis. Acta. Med. Scand., Supp. 77, 78: 426, 1936. Google Scholar2b. MOLTKE O: Ueber das Familiar Auftreten der Chronischen Suppurative Koloproctitis. Klin. Wschr. 15: 124, 1936. CrossrefGoogle Scholar3. JACKMANBARGEN RFJA: Familial occurrence of chronic ulcerative colitis. Amer. J. Dig. Dis. 9: 147, 1942. CrossrefGoogle Scholar4. SLOANBARGENGAGE WPJARP: Life histories of patients with chronic ulcerative colitis: a review of 2,000 cases. Gastroenterology 16: 25, 1950. CrossrefMedlineGoogle Scholar5. PAULSON ME: "Nonspecific or indeterminate colitis," in Diseases of the Digestive System, Lea & Febiger, Philadelphia, 1953, p. 783. Google Scholar6. KIRSNERPALMER JBWL: Clinical course of non-specific ulcerative colitis. JAMA 137: 922, 1948. CrossrefMedlineGoogle Scholar7. PARISHÉRAUD JM: Familial hemorrhagic rectocolitis. Arch. Mal. Appar. Dig. 50: 370, 1961. MedlineGoogle Scholar8. BARKER WF: Familial history of patients with ulcerative colitis. Amer. J. Surg. 103: 25, 1962. CrossrefGoogle Scholar9. HOUGHTONNAISH EAJM: Familial ulcerative colitis and ileitis. Gastroenterologia 88: 65, 1958. CrossrefGoogle Scholar10. BACON HE: Ulcerative colitis. J. B. Lippincott Co., Philadelphia, 1958. Google Scholar11. SCHLESINGERPLATT BJ: Ulcerative colitis in childhood and a follow up study. Proc. Royal Soc. Med. 51: 733, 1958. CrossrefMedlineGoogle Scholar12. CORNESSTREHER JSM: Primary Crohn's disease of the colon and rectum. Gut 2: 189, 1961. CrossrefMedlineGoogle Scholar13. WIGLEYMACLAURIN RDBP: A study of ulcerative colitis in New Zealand, showing a low incidence in maoris. Brit. Med. J. 2: 228, 1962. CrossrefMedlineGoogle Scholar14. CROHN BB: Personal communication. December, 1962. Google Scholar15. BARGEN JA: Personal communication. December, 1962. Google Scholar16 HAMMERLEMMANS MAM: Familial colitis gravis. Nederl. T. Geneesk. 80: 5131, 1936. Google Scholar17. FEDER IA: Chronic ulcerative colitis. An analysis of 88 cases. Amer. J. Dig. Dis. 5: 239, 1938. CrossrefGoogle Scholar18. JULIEN-MARIE L: Rectocolite Hemmorhagique Chez un Enfant. Carostese Familial de l'Affection. Arch. Mal. Appar. Dig. 31: 76, 1942. Google Scholar19. PAULLEY JW: Ulcerative colitis. Gastroenterology 16: 566, 1950. CrossrefMedlineGoogle Scholar20. TIDRICK RT Personal communication, 1962. Google Scholar21. LYONSPOSTLETHWAIT CRRW: Chronic ulcerative colitis in twins. Gastroenterology 10: 545, 1948. MedlineGoogle Scholar22. WEBB LR: The occurrence of ulcerative colitis in twin males. Gastroenterology 15: 523, 1950. CrossrefMedlineGoogle Scholar23. CROHNYARNIS BBH: Regional ileitis. Grune & Stratton, New York, 1958. Google Scholar24. STEIGMANNSHAPIRO FS: Familial regional enteritis. Gastroenterology 40: 215, 1961. CrossrefGoogle Scholar25. SHERLOCKBELLSTEINBERGALMY PBMHTP: Familial occurrences of regional enteritis. Presented at the Annual Meeting American Gastroenterological Association, April, 1962. Google Scholar26. FREYSZHAEMMERLIKARTAGENER HAM: Ileitis regionalis bei einem Weiblichen Zwillingspaar. Gastroenterologia 89: 75, 1958. CrossrefMedlineGoogle Scholar27. LEWISOHN R: Segmental enteritis. Surg. Gynec. Obstet. 66: 215, 1938. Google Scholar28. BROWNSCHEIFFLEY PWCH: Chronic regional enteritis occurring in three siblings. Amer. J. Dig. Dis. 6: 257, 1939. CrossrefGoogle Scholar29. BOCKUS HL: "Chronic stenosing regional enteritis and enterocolitis." in Gastroenterology, Vol. 2, W. B. Saunders Company, Philadelphia, 1946. p. 1620. Google Scholar30. KIRSNEROWENSHUMPHREYS JBFMEM: Regional enteritis in father and son. Gastroenterology 10: 883, 1948. MedlineGoogle Scholar31. REICH H, cited by J. B. Kirsner (30). Google Scholar32. ARMITAGEWILSON GM: Crohn's disease: survey of literature and report on thirty-four cases. Brit. J. Surg. 38: 182, 1950. CrossrefMedlineGoogle Scholar33. EDWARDS HC: Recent Advances in Surgery, 4th ed. J. & A. Churchill, Ltd. London, 1954. Google Scholar34. EUDELVIGNIE FR: Les Formes Caecales de la Maladie de Crohn. Presse Méd. 63: 1846, 1955. MedlineGoogle Scholar35. HEARDJOHN GEEL: Medical memorandum; regional ileitis in mother and son. Brit. Med. J. 2: 85, 1956. CrossrefMedlineGoogle Scholar36. METZGERFROBESE HNAS: Terminal ileitis in a fifteen year old boy and in the mother nineteen years previously. Gastroenterology 31: 439, 1956. CrossrefMedlineGoogle Scholar37. NIEDERLE MB: Regional ileitis in monozygous female twins. Arch. Mal. Appar. Dig. 50: 1245, 1961. MedlineGoogle Scholar38. FELSENWOLARSKY JW: Familial incidence of ulcerative colitis and ileitis. Gastroenterogy 28: 412, 1955. CrossrefMedlineGoogle Scholar39. MELROSE AG: The geographical incidence of chronic ulcerative colitis in Britain. Gastroenterology 29: 1055, 1955. CrossrefMedlineGoogle Scholar40. MELROSE AG: Observations on the European incidence of chronic ulcerative colitis. Gastroenterologia 86: 626, 1956. CrossrefMedlineGoogle Scholar41. WINSTONEHENDERSONBROOKE WEAJBN: Blood groups and secretor status in ulcerative colitis. Lancet 2: 64, 1960. CrossrefMedlineGoogle Scholar42. SMITHTRUELOVE RSSC: Blood groups and secretor status in ulcerative colitis. Brit. Med. J. 1: 870, 1961. CrossrefMedlineGoogle Scholar43. BOYDHEISLEROROWAN WCME: Rh blood groups in ulcerative colitis. Nature (London) 190: 1123, 1961. CrossrefGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: From the Department of Medicine, University of Chicago, Chicago, Illinois.This study was supported in part by grant A-2133 from the National Institute of Arthritis and Metabolic Diseases, National Institutes of Health, Bethesda, Maryland.Presented in part at the Midwest regional meeting of the American College of Physicians, October 20, 1962, and at the Chicago Society of Internal Medicine, January 28, 1963.Requests for reprints should be addressed to Joseph B. Kirsner, M.D., Department of Medicine, University of Chicago, Chicago, Illinois. 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KIRSNER, M.D., PH.D. 1 August 1963Volume 59, Issue 2Page: 133-144KeywordsArthritisColitisEnteritisGenetic diseasesMetabolic disordersPopulation geneticsUlcerative colitis Issue Published: 1 August 1963 CopyrightCopyright ©, 1963, by The American College of PhysiciansPDF DownloadLoading ...