tbuckley/cabot-search huggingface dataset:
The effect of PUVA treatment on circulating lymphocytes
Authors: Roger Clayton, Helgi valdimarsson and, Lionel Fry
Journal: British Journal of Dermatology (1979)

Journal Article The effect of PUVA treatment on circulating lymphocytes Get access Roger Clayton, Roger Clayton Department of Dermatology and Clinical Immunology, St Mary's Hospital, London W2 1NY Search for other works by this author on: Oxford Academic Google Scholar Helgi valdimarsson And, Helgi valdimarsson And Department of Dermatology and Clinical Immunology, St Mary's Hospital, London W2 1NY Search for other works by this author on: Oxford Academic Google Scholar Lionel Fry Lionel Fry Department of Dermatology and Clinical Immunology, St Mary's Hospital, London W2 1NY Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 100, Issue 2, 1 February 1979, Pages 225–226, https://doi.org/10.1111/j.1365-2133.1979.tb05566.x Published: 01 February 1979
Review: Epidural corticosteroids reduce short- but not long-term leg pain and disability in sciatica
Authors: Roger Chou
Journal: Annals of Internal Medicine (2013)

Source Citation Pinto RZ, Maher CG, Ferreira ML, et al. Epidural corticosteroid injections in the management of sciatica: a systematic review and meta-analysis. Ann Intern Med. 2012;157:865-77. 23362516
Dipyridamole 201Tl Myocardial SPECT in the Assessment of a Patient With Myocardial Bridging and Concomitant Atherosclerotic Coronary Artery Disease
Authors: Ping-Ju Hsieh, Hung-Yi Su, Hung-Shun Lo, Meng-Ling Chen
Journal: Clinical Nuclear Medicine (2012)

Myocardial bridging (MB) is a common congenital condition in which a major coronary artery is covered by a bridge of muscle and narrows during systole. We present a patient with typical angina, severe MB of the left anterior descending artery and atherosclerotic coronary artery disease. In this case, dipyridamole 201Tl SPECT myocardial perfusion imaging, besides detecting coronary artery disease, provided supportive evidence that severe MB can cause myocardial ischemia and was useful for the assessment of the interventional outcome, as well as having played a key role in the clinical decision-making process.
CAUSES OF FAILURE IN THE TREATMENT OF VARICOSE VEINS
Authors: GÉZA de TAKÁTS
Journal: JAMA (1931)

Unprecedented interest is shown both by the medical profession and by the public in the subject of varicose veins. A few years ago it was necessary to advocate and argue the cause of injection treatment, particularly before surgeons. Today one may say that this form of treatment has become an accepted, standard procedure, widely used by the general practitioner and favored by the progressive surgeon, who is only too glad to relinquish or reduce the number of extensive operative procedures, with a disconcerting percentage of recurrences. Today it is no longer necessary to fight for the principle of injection treatment, but rather to emphasize the possible errors and mistakes that are frequently made in a type of procedure which is so easily accessible to both physician and patient. There is hardly anything more instructive than to go over the possible mistakes in diagnosis, the indications, and the errors in selecting
BFU-E colony growth in response to hydroxyurea: Correlation between in vitro and in vivo fetal hemoglobin induction
Authors: Yih-Ming Yang, Betty Pace, David Kitchens, Samir K. Ballas, Arvind Shah, B. Surendra Baliga
Journal: American Journal of Hematology (1997)

Patients with sickle-cell anemia treated with hydroxyurea may have significant reduction in frequency and severity of pain episodes. However, previous clinical trials show a variable response to hydroxyurea. Criteria which can be used to select patients who are likely to respond to hydroxyurea treatment would be useful. Our laboratory has previously demonstrated an inverse linear relationship between the total number of burst-forming unit-erythroid (BFU-E) colonies and fetal hemoglobin levels in sickle-cell patients treated with hydroxyurea. In the present report, an in vitro cell culture system was established to evaluate the effects of hydroxyurea on BFU-E colony growth and induction of fetal hemoglobin production. Five Hb SS patients who were not previously treated with hydroxyurea and three Hb SS patients who failed to respond to hydroxyurea treatment were included in the study. The results show that the number of BFU-E colonies is decreased from 153.7 to 7.2 per 3 × 105 mononuclear cells, whereas fetal hemoglobin levels were increased from 5.1 to 19.4% in the presence of hydroxyurea in vitro in cultured erythroid progenitors, which were derived from 5 patients before treatment. The number of BFU-E colonies decreased from 153.7 to 2.0 per 3 × 105 mononuclear cells in the in vitro cultures obtained from serial peripheral blood samples over a 9- to 20-week period of oral hydroxyurea therapy. A simultaneous rise in fetal hemoglobin level from 10.2 to 28.6% in the peripheral blood over the same period of hydroxyurea therapy was also observed. Our results demonstrate that the increase in fetal hemoglobin levels in cells treated with hydroxyurea in vitro is comparable to the rise of fetal hemoglobin production following hydroxyurea therapy in these patients. On the contrary, these findings were not observed in three previously non-responsive sickle-cell patients. These results suggest that the changes in number of BFU-E colonies and fetal hemoglobin levels after in vitro exposure to hydroxyurea may be a useful approach to select sickle-cell patients who will respond to hydroxyurea therapy. Am. J. Hematol. 56:252–258, 1997. © 1997 Wiley-Liss, Inc.
Occam's razor is a double-edged sword: Reduced interaction is not necessarily reduced power
Authors: D. H. Whalen
Journal: Behavioral and Brain Sciences (2000)

Although Norris, McQueen &amp; Cutler have provided convincing evidence that there is no need for contributions from the lexicon to phonetic processing, their simplification of the communication between levels comes at a cost to the processes themselves. Although their arrangement may ultimately prove correct, its validity is not due to a successful application of Occam's razor.
Pruritic urticarial papules and plaques of pregnancy (polymorphic eruption of pregnancy): two unusual cases
Authors: S.A. VAUGHAN JONES, M.G.S. DUNNILL, M.M. BLACK
Journal: British Journal of Dermatology (1996)

We report two unusually florid cases of polymorphic eruption of pregnancy (PEP) or pruritic urticarial papules and plaques of pregnancy, the first occurring in a triplet pregnancy, and the second with some clinical features more suggestive of pemphigoid gestationis (PG). The first case responded to treatment with moderately potent topical steroids while the second case required a short course of systemic steroids. Our first case is the only reported case of PEP occurring during a triplet pregnancy. We discuss the effect of multiple pregnancy on PEP and some distinguishing factors between PEP and PG.
Effect of D600, practolol, and alterations in magnesium on ionized calcium concentration-response relationships in the intact dog heart.
Authors: M R Bristow, J R Daniels, R S Kernoff, D C Harrison
Journal: Circulation Research (1977)

The effect of practolol, D600, and alterations in ionized magnesium concentration on the cardiovascular pharmacology of calcium was examined in vivo in the open-chest dog.In the presence of practolol the ionized calcium-dP/dt (first derivative of left ventricular pressure) concentration-response curve was shifted to the right, with a decreased slope and maximum.Practolol also shifted ionized calcium-S a T, (S wave to peak of T wave on ECG) relationships to the right but in a parallel fashion.Compound D600 produced a parallel shift to the right of ionized calcium-dP/dt relationships but only at maximal doses (0.80 mg/kg).In the presence of practolol, 2.5 mg/kg, D600 shifted ionized calcium-dP/dt relationships to the right at doses (0.8 and 0.25 mg/kg) that had no effect in the absence of practolol.Ionized calcium-dP/dt relationships were the same before and after chelation with EGTA, in contrast to results of the same experiment performed with sodium citrate as the complexing agent.In the intact canine heart, practolol appears to act as a noncompetitive antagonist, D600 as a competitive antagonist, and ionized magnesium as an antagonist of the effects of ionized calcium on dP/dt.D600 in doses of 0.25 mg/kg and 0.80 mg/kg produced hyperglycemia, and this effect was prevented by prior administration of practolol.IN A PREVIOUS study 1 we described a method for determining precise in vivo concentration-response relationships between ionized calcium (Ca 2+ ) and the mechanical and electrical activity of the heart.With this method Ca 2+ raised or lowered by infusions of calcium gluconate or sodium citrate and then directly measured by an ionspecific electrode. 2-3 With this technique Ca 2+ -dP/dt (first derivative of the left ventricular pressure rise) relationships are precise and reliable between 2 and 10 mg/100 ml, and four curves from measurements repeated over a 272-hour interval are superimposable.In our present study we have used this method to define pharmacological relationships between Ca 2+ and members of three classes of agents that are thought to alter the effects of Ca 2+ on the heart: alterations in the level of ionized magnesium (Mg 2+ ), /3-adrenergic blockade with practolol, and "calcium antagonism" with compound D600. MethodsThirty mongrel dogs weighing between 14 and 25 kg were used in this study.Materials and methods were
Ecology of Enteroviruses in the Western Arctic
Authors: Karl R. Reinhard
Journal: JAMA (1963)

Serological and virological data obtained by the author, as well as reports previously published by others, show that human enteroviral infections are prevalent, and probably endemic, throughout most of the western American Arctic region. Serological evidence indicates that polioviruses, particularly Type 2, have been endemic in the aboriginal population of Alaska for many years. Here the seasonal epidemiological patterns differ from those of more southern areas, and wintertime epidemics are frequent. It is likely that epidemics of cryptic enteroviral infections have been the rule in the native villages. In the towns and large cities, however, particularly in their nonaboriginal population, the patterns of immunity and infection are more like those of southern areas.
Effects of London helicopter emergency medical service on survival after trauma
Authors: J P Nicholl, J E Brazier, H A Snooks
Journal: BMJ (1995)

<h3>Abstract</h3> <b>Objective</b>: To assess the effect of the London helicopter emergency medical service on survival after trauma. <b>Design</b>: Prospective comparison of outcomes in cohorts of seriously injured patients attended by the helicopter and attended by London ambulance service land ambulances crewed by paramedics. <b>Setting</b>: Greater London. <b>Subjects</b>: 337 patients attended by helicopter and 466 patients attended by ambulance who sustained traumatic injuries and died, stayed in hospital three or more nights, or had other evidence of severe injury and who were taken to any one of 20 primary receiving hospitals. <b>Main outcome measure</b>: Survival at six months after the incident. <b>Results</b>:After differences in the nature and severity of the injuries in the two cohorts were accounted for the estimated survival rates were the same (relative risk of death with helicopter=1.0; 95% confidence interval 0.7 to 1.4). An analysis with trauma and injury severity scores (TRISS) found 16% more deaths than predicted in the helicopter cohort but only 2% more in the ambulance cohort. There was no evidence of a difference in survival for patients with head injury but a little evidence that patients with major trauma (injury severity score &gt;/=16) were more likely to survive if attended by the helicopter. An estimated 13 (−5 to 39) extra patients with major trauma could survive each year if attended by the helicopter. <b>Conclusion</b>: Any benefit in survival is restricted to patients with very severe injuries and amounts to an estimated one additional survivor of major trauma each month. Over all the helicopter caseload, however, there is no evidence that it improves the chance of survival in trauma.
Diagnosis of Congenital Rubella in Utero
Authors: Myron J. Levin, Michael N. Oxman, Marcie G. Moore, Joan B. Daniels, Kenneth Scheer
Journal: New England Journal of Medicine (1974)

RUBELLA infection of a susceptible pregnant woman is frequently transmitted to her fetus.1 During the first trimester of pregnancy, rubella infection of the fetus is associated with a high rate of severe sequelae.1 , 2 Even after the first trimester rubella infection may result in fetal damage.3 Consequently, when the diagnosis of rubella infection during pregnancy is confirmed, therapeutic abortion is usually considered. However, this diagnosis is often difficult to establish. Facilities for virus isolation are not readily available, and the serologic technics usually used4 require paired serum specimens, the first of which must be obtained before or shortly after infection. In . . .
Leukotriene D4 Induces IL-8 Gene Transcription through CysLT1 Receptor Signalling: Involvement of AP-1 and NF-kB Binding Elements and Cdc42 Small G-protein
Authors: C. Thompson, A. Cloutier, Y. Bossé, C. Le Gouill, P.P. McDonald, J. Stankova, M. Rola-Pleszczynski
Journal: Journal of Allergy and Clinical Immunology (2005)
EQUINE ANTIHAPTEN ANTIBODY
Authors: John H. Rockey
Journal: The Journal of Experimental Medicine (1967)

Eight antigenically unique immunoglobulins have been identified in purified equine anti-p-azophenyl-beta-lactoside (Lac) antibody isolated from a single horse. The Fc fragments of the gammaGa-, gammaGb-, gammaGc-, and -gammaA-globulins have been shown to possess unique antigenic determinants. Common gammaG- and gammaA-Fc fragment antigenic determinants, which were absent from the 10Sgamma(1)- and gammaM-globulins, have also been observed. All antibody populations share two antigenically distinct light (B, L) chain variants. The association of anti-Lac antibody with the hapten p-(p-dimethylamino-benzeneazo)-phenyl-beta-lactoside has been measured by equilibrium dialysis and by fluorescence quenching. A variation in the affinity of anti-Lac antibody for hapten has been observed. The affinity of antibody was unaltered by enzymatic removal of the Fc fragments by peptic digestion or dissociation of the two combining sites on the papain 3.5S Fab fragments, indicating that the observed heterogeneity of affinities was not a direct function of the heterogeneity in structure of the Fc fragments. Isolated heavy (A, H) chains of gammaA-anti-Lac antibody have been shown to have retamed affinity for Lac dye by equilibrium dialysis and by analytical ultracentrifugation, employing a combination of schlieren and absorption optics. The heavy (A, H) chains from two physically separable, antigenically distinct antibody populations, isolated from the same animal and having affinity for the same haptenic determinant, have been found to differ in their amino acid composition. Anti-Lac antibody light (B, L) chains have also been shown to be chemically heterogeneous, and contained populations of polypeptide chains possessing, and populations lacking methionine. The relevance of the observed structural heterogeneity of equine anti-Lac antibody to the problem of defining the mechanism of acquisition of immunological specificity is briefly discussed.
Transient paraproteinaemia in a patient with coeliac disease.
Authors: A S Pena, J V Nieuwkoop, H R Schuit, W T Hekkens, A J Haex
Journal: Gut (1976)

A case is reported of a 43 year old man who suffered from a grass pollen allergy and a malabsorption syndrome and in whom a paraproteinaemia was found. The grass pollen hypersensitivity was abolished by desensitization. The malabsorption syndrome was found to be due to coeliac disease--that is, a "flat" mucosa of the jejunum with an almost normal ileal mucosa--followed by clinical recovery and morphological improvement on a gluten-free diet. A short period of gluten reintroduction caused deterioration of the jejunum. The monoclonal immunoglobulin (IgG-gamma) diminished and disappeared in the course of three years. Although it has not been possible to demonstrate that this paraprotein had anti-gliadin activity, it is suggested that the constant stimulation of the gut reticuloendothelial system by gluten might bear some relation to the appearance of the paraproteinaemia.
Therapeutic value of drugs which modulate nitric oxide homeostasis
Authors: A. Vegh
Journal: Cardiovascular Research (1994)

Journal Article Therapeutic value of drugs which modulate nitric oxide homeostasis Get access Agnes Vegh Agnes Vegh Department of Pharmacology, Albert Szent-Gyorgyi Medical University, Szeged, Hungary Search for other works by this author on: Oxford Academic PubMed Google Scholar Cardiovascular Research, Volume 28, Issue 1, January 1994, Pages 140–141, https://doi.org/10.1093/cvr/28.1.140 Published: 01 January 1994
Chocolate and Blood Pressure in Elderly Individuals With Isolated Systolic Hypertension
Authors: D. Taubert
Journal: JAMA (2003)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Interim positron emission tomography scans in diffuse large B-cell lymphoma: an independent expert nuclear medicine evaluation of the Eastern Cooperative Oncology Group E3404 study
Authors: Sandra J. Horning, Malik E. Juweid, Heiko Schöder, Gregory Wiseman, Alex McMillan, Lode J. Swinnen, Ranjana Advani, Randy Gascoyne, Andrew Quon
Journal: Blood (2009)
Regulation of Vav Localization in Membrane Rafts by Adaptor Molecules Grb2 and BLNK
Authors: Sachiko Johmura, Masatsugu Oh-hora, Kazunori Inabe, Yumiko Nishikawa, Katsuhiko Hayashi, Elena Vigorito, Daisuke Kitamura, Martin Turner, Koh Shingu, Masaki Hikida, Tomohiro Kurosaki
Journal: Immunity (2003)
Doctors seek ruling on nuclear weapons
Authors: T Sheldon
Journal: BMJ (1994)

A bid to declare the use of nuclear weapons illegal on health grounds has been launched in the International Court of Justice in the Hague. The World Health Organisation has asked for a ruling after a controversial decision by last year's WHO Assembly that the action lay within its remit. The court is being asked to rule whether the use of nuclear weapons breaches the WHO's obligations under international law.

The case is likely to last a year after the deadline (10 June) for …
ON ORIENTAL STOICISM
Authors: JAMES CLARK MOLONEY
Journal: American Journal of Psychiatry (1946)

The unruffled mien of the Asiatic is legendary. When not attributed to constitutional factors, it is traditional for the Occidental to believe that the Oriental, deliberately blocks the natural egress of emotional energy. It is generally supposed that the flatness of affect is achieved through a studied and energetic suppression of feeling. Oriental unresponsiveness has been likened to the active stoicism of the Spartan youth, who unwincingly permitted a fox to eat out his entrails. Calmness under such circumstances demands the utmost in energy suppression. But energy is indestructible. Its normal egress blocked, it canalizes physiological pathways neither designed nor adapted to its use. The surge and impact charge strange tissues with severe and unexpected stresses. In time these stresses induce demonstrable structural changes. This dynamism embraces the most fundamental evocative of psychosomatic disease. Since the Okinawa Oriental is free from psychosomatic disease, one is forced to the conclusion that the Okinawan neither consciously suppresses nor unconsciously represses his emotional intent. Incredible as it may seem, he just doesn't react to situations which customarily disturb the Occidental. The Oriental is different.
Severe hypophosphataemia during recovery from acute respiratory acidosis.
Authors: T L Storm
Journal: BMJ (1984)

Three elderly patients with established chronic obstructive airways disease were admitted with a short history of increasing dyspnoea and tiredness and (in two cases) a deterioration in mental state. Acute respiratory acidosis was diagnosed and mechanical ventilation instituted. Two hours after beginning mechanical ventilation the mean arterial pH had risen to 7.40, but all patients showed a dramatic fall in the serum phosphate concentration (lowest value 0.3 mmol/l (0.9 mg/100 ml] accompanied by a low urinary excretion of phosphate. No patient could tolerate withdrawal of mechanical ventilation until the serum and urinary concentrations of phosphate had returned to normal. Recovery from acute respiratory acidosis should be added to the list of conditions associated with severe hypophosphataemia.
Angioneurotic Edema and Deficiency of C′1 Esterase Inhibitor in a 61-Year-Old Woman
Authors: SIGURDUR E. THORVALDSSON
Journal: Annals of Internal Medicine (1969)

Angioneurotic edema and symptoms of intestinal obstruction developed in a woman when she was 58 years old. Surgical exploration during an attack of abdominal pain showed a segment of jejunum that was edematous and thickened and had a narrowed lumen. Analysis of the patient's serum showed a reduction in C′4 activity and a marked deficiency of C′1 esterase inhibitor, the biochemical hallmarks of hereditary angioneurotic edema. There was no family history of angioneurotic edema. The patient later died from an attack of laryngeal edema. This case illustrates the need for analysis of serum for this deficiency in elderly patients with angioneurotic edema and abdominal pain even though the family history is negative.
Benign papular acantholytic non-dyskeraotic eruption: a new paraneoplastic syndrome?
Authors: Th. van Joost, V.D. Vuzevski, H.E. Menke
Journal: British Journal of Dermatology (1989)

Journal Article Benign papular acantholytic non‐dyskeraotic eruption: a new paraneoplastic syndrome? Get access Th. van Joost, Th. van Joost Department of Dermatology and Pathology, Erasmus University, Rotterdam, The Netherlands Search for other works by this author on: Oxford Academic Google Scholar V.D. Vuzevski, V.D. Vuzevski Department of Dermatology and Pathology, Erasmus University, Rotterdam, The Netherlands Search for other works by this author on: Oxford Academic Google Scholar H.E. Menke H.E. Menke Department of Dermatology, St Franciscus Hospital, Rotterdam, The Netherlands Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 121, Issue 1, 1 July 1989, Pages 147–148, https://doi.org/10.1111/j.1365-2133.1989.tb01416.x Published: 01 July 1989