tbuckley/cabot-search huggingface dataset:
Design options and methodological fallacies in the studies of reproductive failures.
Authors: J Olsen, T Skov
Journal: Environmental Health Perspectives (1993)

Reproductive failures are at first sight well suited for epidemiologic research. The time of pregnancy is closely monitored, and failures such as spontaneous abortions and subfecundity are rather frequent. Although epidemiologists' interest in the field has been growing, there is still disappointingly little new information of relevance for prevention. A number of methodologic shortcomings may explain this. A large part of disease classification is not well suited for etiologic research, reduced fertility has diminished the populations at risk, close medical monitoring tends to mask causal links, and many scientific problems related to this area bring limitations to the research field. Still, much more could be learned from a systematic use of epidemiologic knowledge, existing registers, and the joint effort between different research groups.
The Human Complement System in Health and Disease.
Authors: B P. MORGAN
Journal: Annals of the Rheumatic Diseases (1998)

<h3>Abstract</h3> Following the emergence of SARS-CoV-2 in China in late 2019 a number of variants have emerged, with two of these – Alpha and Delta – subsequently growing to global prevalence. One characteristic of these variants are changes within the Spike protein, in particular the receptor binding domain (RBD). From a public health perspective these changes have important implications for increased transmissibility and immune escape; however, their presence could also modify the intrinsic host-range of the virus. Using viral pseudotyping we examined whether the variants of concern (VOCs) Alpha, Beta, Gamma and Delta have differing host ACE2 receptor usage patterns, focusing on a range of relevant mammalian ACE2 proteins. All four VOCs were able to overcome a previous restriction for mouse ACE2, with demonstrable differences also seen for individual VOCs with rat, ferret or civet ACE2 receptors, changes which we subsequently attribute to N501Y and E484K substitutions within the Spike RBD.
Eliminating Rubella From the United States-Reply
Authors: Walter A. Orenstein
Journal: JAMA (1986)

In Reply.—  We are gratified that Dr Kindrachuk made the efforts he did to try to ensure mothers of children were immune to rubella. We would like to clarify some points that should facilitate assessing the immunity status of mothers and offering vaccine.  Several courses of action are available to physicians in well-baby clinics to determine immunity to rubella and to offer vaccine. Acceptable evidence of rubella immunity should be considered either documentation of receipt of rubella vaccine on or after the first birthday or documentation of a serological test demonstrating rubellaspecific antibodies. 1 Women lacking such evidence can be vaccinated without serological screening (the preferred course), screened by serological tests and offered vaccine at a later date if the test indicates susceptibility, or referred to their own physician for evaluation. All alternatives are acceptable but vaccinating without screening saves the patient the cost of the serological test and avoids
Dementia incidence and mortality in middle-income countries, and associations with indicators of cognitive reserve: a 10/66 Dementia Research Group population-based cohort study
Authors: Martin Prince, Daisy Acosta, Cleusa P Ferri, Mariella Guerra, Yueqin Huang, Juan J Llibre Rodriguez, Aquiles Salas, Ana Luisa Sosa, Joseph D Williams, Michael E Dewey, Isaac Acosta, Amuthavalli T Jotheeswaran, Zhaorui Liu
Journal: The Lancet (2012)
The Good and Long Life
Authors: C. E. Miller
Journal: JAMA (1971)

ABSTRACT To the Editor.— If a layman (who thinks of himself as a professional in his own field, but is not an MD) may comment to the physician readers of your journal, I noted with considerable interest the article in MEDICAL NEWS (214:1636, 1970) which stated that men who attend church regularly do not have heart attacks, whereas backsliders and infrequent worshippers drop like flies.Assuming that irrelevant correlations have now been given the weight of scientific fact, I am moved to point out that I have proved the healthiest age for physicians to be between 95 and 99 years.From the obituary pages of the Nov 30 issue of THE JOURNAL, I did some scientifically accurate calculations and determined that the average age of death for 58 randomly selected physicians reported therein was 66.57 years. Following is a breakdown of the number who died in each of several scientifically
Care of dying patients in hospital
Authors: M Mills, H T O Davies, W A Macrae
Journal: BMJ (1994)

<h3>Abstract</h3> <b>Objective</b> : To study the process of care of dying patients in general hospitals. <b>Design</b> : Non-participant observer (MM) carried out regular periods of continuous comprehensive observation in wards where there were dying patients, recording the quantity and quality of care given. Observations were made in 1983. <b>Setting</b> : 13 wards (six surgical, six medical, and one specialist unit) in four large teaching hospitals (bed capacity 504-796) in west of Scotland. <b>Subjects</b> : 50 dying patients (29 female, 21 male) with mean age of 66 (range 40-89); 29 were dying from cancer and 21 from non-malignant disease. <b>Results</b> : Final period of hospitalisation ranged from 6 hours to 24 weeks. More than half of all patients retained consciousness until shortly before death. Basic interventions to maintain patients9 comfort were often not provided: oral hygiene was often poor, thirst remained unquenched, and little assistance was given to encourage eating. Contact between nurses and the dying patients was minimal;20distancing and isolation of patients by most medical and nursing staff were evident; this isolation increased as death approached. <b>Conclusions</b> : Care of many of the dying patients observed in these hospitals was poor. We need to identify and implement practical steps to facilitate high quality care of the dying. Much can be learned from the hospice movement, but such knowledge and skills must be replicated in all settings.
Myosin light chains release in acute myocardial infarction: non-invasive estimation of infarct size
Authors: H. A KATUS, K. W DIEDERICH, M. UELLNER, A. REMPPIS, G. SCHULER, W. KUBLER
Journal: Cardiovascular Research (1988)

Journal Article Myosin light chains release in acute myocardial infarction: non-invasive estimation of infarct size Get access HUGO A KATUS, HUGO A KATUS From the Department of Internal Medicine III (Cardiology), University of Heidelberg, Heidelberg, Federal Republic of Germany Search for other works by this author on: Oxford Academic PubMed Google Scholar KLAUS W DIEDERICH, KLAUS W DIEDERICH From the Department of Internal Medicine III (Cardiology), University of Heidelberg, Heidelberg, Federal Republic of Germany Search for other works by this author on: Oxford Academic PubMed Google Scholar MARTIN UELLNER, MARTIN UELLNER From the Department of Internal Medicine III (Cardiology), University of Heidelberg, Heidelberg, Federal Republic of Germany Search for other works by this author on: Oxford Academic PubMed Google Scholar ANDREW REMPPIS, ANDREW REMPPIS From the Department of Internal Medicine III (Cardiology), University of Heidelberg, Heidelberg, Federal Republic of Germany Search for other works by this author on: Oxford Academic PubMed Google Scholar GERHARD SCHULER, GERHARD SCHULER From the Department of Internal Medicine III (Cardiology), University of Heidelberg, Heidelberg, Federal Republic of Germany Search for other works by this author on: Oxford Academic PubMed Google Scholar WOLFGANG KÜBLER WOLFGANG KÜBLER From the Department of Internal Medicine III (Cardiology), University of Heidelberg, Heidelberg, Federal Republic of Germany Search for other works by this author on: Oxford Academic PubMed Google Scholar Cardiovascular Research, Volume 22, Issue 7, July 1988, Pages 456–463, https://doi.org/10.1093/cvr/22.7.456 Published: 01 July 1988 Article history Received: 20 October 1987 Accepted: 02 March 1988 Published: 01 July 1988
EFFECT OF A STANDARDIZED BODY MASS INDEX- AND HEART RATE-BASED PROTOCOL ON RADIATION DOSE AND DIAGNOSTIC ACCURACY OF CORONARY COMPUTED TOMOGRAPHIC ANGIOGRAPHY: A PROSPECTIVE MULTICENTER STUDY
Authors: Troy LaBounty, Jonathon Leipsic, G.B. John Mancini, Brett Heilbron, Smita Patel, Ella A. Kazerooni, Fay Y. Lin, Adam Saltzman, Giora Weisz, Jonathan W. Weinsaft, Jin-Ho Choi, Nina Koduru, James K. Min
Journal: Journal of the American College of Cardiology (2010)
P190Deficiency of non-endothelial eNOS causes hypertension in mice
Authors: T Suvorava, J Stegbauer, M Thieme, S Pick, C Rump, JW Fischer, T Hohlfeld, G Kojda
Journal: Cardiovascular Research (2014)

Purpose: Despite irrefutable role of endothelial nitric oxide synthase (eNOS) in vascular smooth muscle tone, its contribution to the regulation of blood pressure has been proven mainly either by the global eNOS-deficiency or by the use of unspecific NOS-inhibitors. To distinguish the relevance of endothelial and non-endothelial eNOS, we generated a novel double transgenic mouse model lacking eNOS in all organs except the vascular endothelium. The aim of the study was to evaluate the contribution of non-endothelial eNOS to the regulation of blood pressure (BP).
Tobacco Toll in China
Authors: Rebecca Voelker
Journal: JAMA (1999)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
1088-123 Cancion cardiac recovery system: Hemodynamic and renal effects
Authors: Michael R Zile, Ron Oren, Adrian Van Bakel, Paul Mohacsi, Michael Bohm, Bernd Hammer, Sinisa Gradinac, Jerzy Sadowski, Krzysztof Bartus, Andre Wasler, Marvin A Konstam
Journal: Journal of the American College of Cardiology (2004)
Sympathectomy inhibits the vasoactive effects of nicotine in conscious rats
Authors: G Marano
Journal: Cardiovascular Research (1999)

The mechanisms underlying the pressor response to nicotine are incompletely understood. Although sympatho-adrenergic activation plays a major role, the relative contribution of adrenal vs. neurally released catecholamines and the possible role of non-adrenergic factors (e.g. vasopressin release) is not established.We examined the cardiovascular responses to graded i.v. injections of nicotine (1 to 100 micrograms kg-1) in conscious Wistar-Kyoto rats under control conditions and (i) after chemical sympathectomy by 6-hydroxydopamine, which destroys sympathetic endings but spares the adrenal medulla; (ii) after an alpha-adrenergic blockade by phenoxybenzamine; (iii) after a V1 vasopressin receptor blockade by a specific antagonist.In control rats, nicotine caused a dose-dependent tachycardiac and pressor response. Both responses were abolished by sympathectomy, whereas the alpha-blockade left the tachycardiac response unaffected but inhibited the pressor response: the V1 vasopressin receptor blockade had no effect on either the tachycardiac or pressor response.We conclude that in the conscious rat; (1) the pressor response to nicotine mainly depends on peripheral alpha-adrenergically-mediated vasoconstriction; (2) the vasomotor effect is caused by neural rather than adrenomedullary catecholamine release; (3) the nicotine-induced increase in heart rate (and presumably cardiac output) is per se unable to raise blood pressure, and (4) the nicotine-induced release of vasopressin plays no significant role in the pressor response.
ANTICARDIAC ANTIBODIES IN ACUTE RHEUMATIC FEVER AND CHRONIC RHEUMATIC HEART DISEASE - ANALYSIS FROM INDIAN AND RUSSIAN PATIENTS
Authors: Bernhard Maisch, Daniela Tontsch, Thorsten G. Loof, Gursharan S. Chhatwal, Anil Grover, Volker Ruppert, Sabine Pankuweit
Journal: Journal of the American College of Cardiology (2010)
Examination for Posterior Subcapsular Cataracts
Authors: Dan M. Gordon
Journal: JAMA (1961)

IN MAY, 1960, the rheumatologists of this group were contacted by Black and Bunim concerning their study then in progress, which revealed a 39 per cent incidence of posterior subcapsular cataracts (hereafter called PSC) in 47 patients with rheumatoid arthritis who had been treated with corticosteroids for two years or longer. It was suggested that as many patients with rheumatoid arthritis as possible who had received prolonged corticosteroid therapy by us be examined for PSC. <h3>Subjects and Procedures</h3> Because the dangers involved in attempting to draw conclusions from a small series were realized, and because we did not want to risk the possibility of chance occurrence, an intensive program was instituted. One phase of this program was to examine under the slit lamp as many corticosteroidtreated rheumatoid arthritics as possible in preparation for the discussion of the report by Black and co-workers.<sup>1</sup>The second phase of the program
FDA May Get Welcome New Funds in Its Budget
Authors: Charles Marwick
Journal: JAMA (1999)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Risk assessment in adult acute lymphoblastic leukaemia before early haemopoietic stem cell transplantation with a geno-identical donor: an easy clinical prognostic score to identify patients who benefit most from allogeneic haemopoietic stem cell transplantation
Authors: N-C Gorin, M Labopin, E Polge, C Cordonnier, J P Jouet, M Michallet, D Blaise, J Reiffers, B Rio, N Milpied, F Frassoni
Journal: Leukemia (2003)
The Oxford classification of IgA nephropathy: pathology definitions, correlations, and reproducibility
Authors: Ian S.D. Roberts, H. Terence Cook, Stéphan Troyanov, Charles E. Alpers, Alessandro Amore, Jonathan Barratt, Francois Berthoux, Stephen Bonsib, Jan A. Bruijn, Daniel C. Cattran, Rosanna Coppo, Vivette D'Agati, Giuseppe D'Amico, Steven Emancipator, Francesco Emma, John Feehally, Franco Ferrario, Fernando C. Fervenza, Sandrine Florquin, Agnes Fogo, Colin C. Geddes, Hermann-Josef Groene, Mark Haas, Andrew M. Herzenberg, Prue A. Hill, Ronald J. Hogg, Stephen I. Hsu, J. Charles Jennette, Kensuke Joh, Bruce A. Julian, Tetsuya Kawamura, Fernand M. Lai, Lei-Shi Li, Philip K.T. Li, Zhi-Hong Liu, Bruce Mackinnon, Sergio Mezzano, F. Paolo Schena, Yasuhiko Tomino, Patrick D. Walker, Haiyan Wang, Jan J. Weening, Nori Yoshikawa, Hong Zhang
Journal: Kidney International (2009)
Suicide in the Elderly: A Practitioner's Guide to Diagnosis and Mental Health Intervention
Authors: T. L. Brink
Journal: JAMA (1986)

There are few gaps and overlaps in this edited work. The chapters fit together to form a comprehensive review of the information and techniques relevant to the study, assessment, and management of suicidal risk in later life. Only the introduction and first chapter are concerned with demographic data. The latter also uses case material to profile those at risk, such as the divorced, alcoholic white male. The remainder of the nearly dozen chapters are generally practical for the clinician: assessment (depression, well-being, and suicidal risk), prevention (psychotherapy, stress management, and societal changes), and management (psychotropics, support groups, reminiscence, and creative therapies such as art, music, movement, etc). Both the editor and the chapter authors have performed their tasks admirably. The content is mostly state of the art, comprehensive, and useful. The review of geriatric psychotherapy and psychopharmacology is succinct without being skimpy. The reviews of the literature cite the major
Targeting mitogen-activated protein kinase kinase with the inhibitor PD0325901 decreases hepatocellular carcinoma growth in vitro and in mouse model systems
Authors: Matthew Hennig, Michele T. Yip‐Schneider, Sabrina Wentz, Huangbing Wu, S. K. Hekmatyar, Patrick Klein, Navin Bansal, C. Max Schmidt
Journal: Hepatology (2009)

Hepatocellular carcinoma (HCC) is a common cause of death from solid organ malignancy worldwide. Extracellular signal-regulated/mitogen-activated protein kinase kinase (MEK) signaling is a critical growth regulatory pathway in HCC. Targeting MEK with a novel small molecule inhibitor, PD0325901, may inhibit HCC tumorigenesis. PD0325901 (0.01-100 nM) inhibited growth and MEK activity in vitro in immortalized murine transforming growth factor alpha (TGF-α) transgenic hepatocyte (TAMH) cells, derived from the livers of TGF-α transgenic mice. Treatment of athymic mice bearing TAMH flank tumors with vehicle or PD0325901 (20 mg/kg) revealed a significant reduction of MEK activity ex vivo 24 hours after a single PD0325901 dose. The growth rate of TAMH flank tumors over 16 days was reduced threefold in the treatment arm (1113 ± 269% versus 3077 ± 483%, P < 0.01). PD0325901 exhibited similar inhibitory effects in HepG2 and Hep3B human HCC cells in vitro and in Hep3B flank tumors in vivo. To confirm this in a developmental model, MT-42 (CD-1) TGF-α mice were treated with vehicle or PD0325901 (20 mg/kg) for 5 weeks. Gross HCC was detected in 47% and 13.3% of the control and treatment mice, respectively. Tumor growth suppression by PD0325901 relative to vehicle was also shown by magnetic resonance imaging. These studies provide compelling preclinical evidence that targeting MEK in human clinical trials may be promising for the treatment of HCC. (HEPATOLOGY 2010.)
Pulmonary Legionnaires' Disease Without Pneumonia
Authors: Fredy P. Roland
Journal: JAMA (1981)

To the Editor.—  Storch et al (1981; 245:587), evaluating the chest roentgenograms in sporadic cases of Legionnaires' disease diagnosed by serological findings, commented that the roentgenograms would be indistinguishable from those showing pneumococcal pneumonia. They obtained only 18 of 100 sets of roentgenograms they sought, explaining that the patients whose physicians sent them (18) may have been different from those whose physicians did not. Maybe some of the roentgenograms not sent were normal. Tsai et al, 1 describing the Philadelphia epidemic, mentioned mild respiratory illness without radiographic evidence of  in 28 patients. Many persons exposed to Legionella may not acquire the severe pneumonia associated with epidemic and sporadic cases.  Report of a Case.—  We report the case of a 34-year-old female technologist who felt sick one day. Two days later she had a temperature of 38 °C with a sore throat, chills, and a dry cough. Physical examination showed
Treatment of ulcerative colitis in the cottontop tamarin using antibody to tumour necrosis factor alpha.
Authors: P E Watkins, B F Warren, S Stephens, P Ward, R Foulkes
Journal: Gut (1997)

BACKGROUND: The aetiology and pathophysiology of ulcerative colitis remains unclear; however, there is increasing recognition of the critical role of inflammatory cytokines in the pathogenesis of this disease. Among these, tumour necrosis factor alpha (TNF alpha) seems to play an important role. AIM: To study the effects of an engineered human monoclonal antibody to TNF alpha (CDP571) in the treatment of idiopathic ulcerative colitis in the cottontop tamarin. METHODS: Six cottontop tamarins with confirmed ulcerative colitis received repeated doses of CDP571. Progression of disease was assessed by measuring both body weight and rectal biopsy pathology. RESULTS: All animals showed a rapid improvement in clinical condition and rectal biopsy pathology that was maintained following completion of the therapy. CONCLUSION: These studies indicate the efficacy of selective antibody therapy to TNF alpha for the treatment of ulcerative colitis in a primate and suggest that similar therapy in human could be of value.