tbuckley/cabot-search huggingface dataset:
Abstract 20364: Successful Ablation of Ventricular Fibrillation in Malignant Bileaflet Mitral Valve Prolapse Syndrome
Authors: Faisal F Syed, Peter Noseworthy, Christopher McLeod, Suraj Kapa, Siva Mulpuru, Chenni Sriram, Bryan Cannon, Samuel Asirvatham, Michael Ackerman
Journal: Circulation (2014)

Introduction: Although the vast majority of mitral valve prolapse (MVP) is benign, women with bileaflet MVP (biMVP), complex ventricular ectopy (VE), and abnormal T waves may comprise the recently described malignant biMVP syndrome. The mechanism of ventricular arrhythmia is unknown. To further characterize the arrhythmic substrate, we reviewed our center’s ablation experience in 6 biMVP patients with prior cardiac arrest and recurrent ICD shocks for drug refractory ventricular fibrillation (VF). Methods and Results: Six women with biMVP (median age 31.5 [range 24.2 - 58.7] years, EF 65 [45 - 67]%, all ≤moderate mitral regurgitation) experienced 6 (3 - 25) appropriate ICD shocks over 4.8 (2.8 - 10.7) years and underwent index ablation between 2/2007 - 10/2013. All had multiple VE morphologies (median 7 [3 - 24]) with variable coupling intervals but with a predominant VE trigger for the VF. A median 2 (1 - 4) VE foci were ablated. Sites of successful ablation of VF-triggering and other dominant VE were left ventricular papillary muscles [PM] (1 anterior, 1 posterior, 1 both), fascicles (1 anterior, 1 posterior), or both (1 both PM and posterior fascicle). Outflow tract VE was also present and targeted (1 left, 1 right)i. Two underwent repeat ablation (288 and 312 days) for recurrent complex VE without shocks, with different foci to the index ablation (1 posterior fascicle, 1 both fascicles). The VF-triggering VE in all patients was confirmed as originating from within the left fascicular system, which in 3/6 was at a papillary muscle. Acute procedural success was seen in all with no complications to date. A VF storm occurred within 24 hours of ablation in a single patient. At follow-up of a mean 662 (47 - 2099) days, 1 patient received a single shock (p=0.03 vs. preablation). Symptomatic VE was reduced in all; while 3/6 continue Class 1c antiarrhythmics and 5/6 have beta blockade. Conclusion: Malignant biMVP syndrome is characterized by fascicular and papillary muscle PVCs that trigger ventricular fibrillation, yet in all patients, the VE is multifocal. Ablation of at least one focus appears to improve symptoms and reduce shocks.
Disturbances in Lipid and Lipoprotein Metabolism.
Authors: John M. Dietschy, Antonio M. Gotto, Joseph Andrew Ontko
Journal: Annals of Internal Medicine (1978)

The weaknesses are scanty and well localised.For instance, in one of the home team's contributions, claiming to show a reduction of gliadin toxicity by enzymic cleavage of a carbohydrate side chain, the key to the symbols in the figures is defective, nullifying detailed interpretation.The chief strength is that this is a faith- ful piece of reporting, conveying the atmosphere in the discussions as well as accurately presenting the papers.
BRCA2 Germline Mutations in Familial Pancreatic Carcinoma
Authors: S. A. Hahn, B. Greenhalf, I. Ellis, M. Sina-Frey, H. Rieder, B. Korte, B. Gerdes, R. Kress, A. Ziegler, J. A. Raeburn, D. Campra, R. Grutzmann, H. Rehder, M. Rothmund, W. Schmiegel, J. P. Neoptolemos, D. K. Bartsch
Journal: JNCI Journal of the National Cancer Institute (2003)

Background: Although as many as 10% of pancreatic cancer cases may have an inherited component, familial pancreatic cancer has not been linked to defects in any specific gene. Some studies have shown that families with germline mutations in the breast cancer susceptibility gene BRCA2 have an increased risk of breast and ovarian cancers, as well as a modestly increased risk of pancreatic cancer. To study these relationships in more detail, we examined whether BRCA2 germline mutations are associated with familial pancreatic cancer. Methods: We identified 26 European families in which at least two first-degree relatives had a histologically confirmed diagnosis of pancreatic ductal adenocarcinoma. We sequenced genomic DNA isolated from peripheral blood lymphocytes obtained from participating family members to identify germline mutations in BRCA2. Results: Three (12%, exact 95% confidence interval [CI] = 2% to 30%) families carried germline frameshift mutations in the BRCA2 gene that are predicted to result in a truncated BRCA2 protein. Two additional families harbored mutations previously designated as unclassified variants of BRCA2. Thus, 19% (exact 95% CI = 7% to 39%) of the families in our study had either a frameshift mutation or an unclassified variant of BRCA2. None of the families in our study met the criteria for familial breast or ovarian cancer. Conclusions: Our data support an important role for BRCA2 germline mutations in a subpopulation of families with familial pancreatic cancer. BRCA2 mutation analysis should be included in molecular genetic testing and counseling strategies in families with at least two first-degree relatives affected with ductal adenocarcinoma of the pancreas.
Ophthalmic Myology. A Systematic Treatise on the Ocular Muscles.
Authors: Giles Christopher Savage
Journal: JAMA (1902)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Low Grade Gliomas and Oligodendrogliomas in Adulthood
Authors: Derek R. Johnson, Kurt A. Jaeckle
Journal: Neuro-Oncology (2012)

Low grade gliomas (LGG) are slow-growing brain tumors that typically affect young adults. While treatable with surgery, radiation, and chemotherapy, LGG are not curable and carry a poorer prognosis than is generally recognized. We review the diagnosis, natural history, and treatment of LGG, with an emphasis on evidence-based management options as well as areas of ongoing research.
Abstract 1738: Lone Atrial Fibrillation: Long-Term Clinical and Echocardiographic Follow-up from the Canadian Registry of Atrial Fibrillation
Authors: Peter Leong-Sit, Karin H Humphries, May Lee, George J Klein, Robert Sheldon, Stuart J Connolly, Martin S Green, Mario Talajic, Paul Dorian, Charles R Kerr
Journal: Circulation (2007)

Background: The natural history of lone atrial fibrillation (AF) is unclear with conflicting data in the literature. We aimed to better describe the clinical outcomes and echocardiographic changes associated with lone AF. Methods: The Canadian Registry of Atrial Fibrillation (CARAF) enrolled 803 non-surgical and non-flutter patients with new onset AF between 1990 and 1996. At enrollment, patients were classified as lone AF (LAF) or not lone AF (Not LAF) based on structural heart disease or hyperthyroidism. Clinical data was prospectively collected with follow-up at 3 months, 1 year, then annually; echocardiograms were performed at enrollment and years 2, 4, and 7. Results: The LAF group (n=212) had a median age of 57 (1 st quartile 44, 3 rd quartile 67) while the Not LAF group (n=591) had a median age of 67 (59, 73), p&lt;0.0001. During the median follow-up of 8 years in the LAF group and 7 years in the Not LAF group, there was a significant difference in survival free from stroke or embolism favoring the LAF group (Figure ). At 8 years, the probability of remaining free of chronic AF was 78.8% vs 69.3% (p=0.02) and free of symptomatic or documented recurrence of AF was 40.1% vs 26.9% (p&lt;0.01) in the LAF vs Not LAF group. The LAF group had smaller LV diastolic and systolic dimensions by 5.5% and 10.2%, respectively, vs the Not LAF group (p&lt;0.0001). The LV mass was smaller at baseline by 21.1% (p&lt;0.0001) vs the Not LAF group, but increased at a greater rate (4.0% vs 0.9%/2 years, p&lt;0.0001). Conclusions: Lone AF, compared to non-lone AF, is associated with a lower rate of death, stroke or embolism, recurrence and progression to chronic AF. Interestingly, LV mass increased significantly only in the Lone AF group.
Yellow jacket allergy
Authors: S. Jeep, G. Reiprich, G. Kunkel
Journal: Allergy (1992)

The aim of the present study was to compare yellow jacket venom extracts from two different companies and to compare skin prick test (SPT) with intradermal test (IDT). IDT and SPT with yellow jacket venom (ALK and Pharmacia Reless®) were performed on 54 yellow jacket allergic patients and 44 symptom‐free volunteers. Venom was diluted to 300, 100, 10 and 1 μ/ml for SPT and 10 0 , 10 −1 , 10 −2 , 10 −3 and 10 −4 μ/ml for IDT, according to the manufacturers’instructions. Skin tests were performed on both forearms. Both extracts showed approximately the same relationship between sensitivity and specificity, but the Pharmacia Reless yellow jacket venom extract showed a 5–10 fold higher biological activity in both SPT and IDT. Thus yellow jacket venoms of ALK and Pharmacia Reless are not comparable in allergen activity at the same venom concentrations. Using extracts from the same company, SPT and IDT were comparable with regard to sensitivity and specificity at an allergen concentration 1000 times higher for SPT than for IDT.
CONTINUOUS FEVER OF INTESTINAL ORIGIN
Authors: B B CROHN, H YARNIS
Journal: Annals of Internal Medicine (1947)

Article1 June 1947CONTINUOUS FEVER OF INTESTINAL ORIGINBURRILL B. CROHN, M.D., F.A.C.P., HARRY YARNIS, M.D.BURRILL B. CROHN, M.D., F.A.C.P.Search for more papers by this author, HARRY YARNIS, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-26-6-858 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptNo phase of medicine is more fascinating, no problem in the clinical sciences more elusive than the picture of low-grade continuing fever that defies elucidation. Many interesting theses have been written upon this topic, among the most important and recent being those of Hamman and Wainwright1in 1936, Kintner and Rowntree2in 1934, and of Reimann3in 1936. In these various treatises one reads of possible causes of such fever, causes which are recognized in classical medicine, such as tuberculosis, syphilis, rheumatic fever, tularemia, brucellosis, pyogenic infections, bacterial endocarditis, Hodgkin's disease, new-growths, and fevers of psychogenic origin. In none of...Bibliography1. HAMMANWAINWRIGHT LCW: Diagnosis of obscure fever; diagnosis of unexplained long-continued low grade fever, Bull. Johns Hopkins Hosp., 1936, lxviii, 109-307. Google Scholar2. KINTNERROWNTREE ARLG: Long continued, low grade, idiopathic fever; analysis of 120 cases, Jr. Am. Med. Assoc., 1934, cii, 889. CrossrefGoogle Scholar3. REIMANN HA: Problem of long continued, low grade fever, Jr. Am. Med. Assoc., 1936, cvii, 1089-1094. CrossrefGoogle Scholar4. GRIFFIN WA: Possible explanation of symptoms of undulant fever, New England Jr. Med., 1930, ccii, 324. CrossrefGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: BURRILL B. CROHN, M.D., F.A.C.P.; HARRY YARNIS, M.D.Affiliations: New York, N. Y.*Received for publication June 1, 1946.From the Medical Services of the Mount Sinai Hospital, New York. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byFEVER WITHOUT SOURCE AND FEVER OF UNKNOWN ORIGINFever of unknown origin in childrenRegional enteritisSegmental (Ulcerative) ColitisDie Ileitis regionalisIsolated jejunal involvement in regional enteritis 1 June 1947Volume 26, Issue 6 Page: 858-862 Keywords Brucellosis Endocarditis Fevers Hodgkin lymphoma Infectious diseases Medical services Rheumatic fever Syphilis Tuberculosis Tularemia ePublished: 1 December 2008 Issue Published: 1 June 1947 PDF downloadLoading ...
Surface Tension Triggered Wetting and Point of Care Sensor Design
Authors: Eric J. Falde, Stefan T. Yohe, Mark W. Grinstaff
Journal: Advanced Healthcare Materials (2015)

Rapid, simple, and inexpensive point-of-care (POC) medical tests are of significant need around the world. The transition between nonwetting and wetted states is used to create instrument-free surface tension sensors for POC diagnosis, using a layered electrospun mesh with incorporated dye to change color upon wetting. As a service to our authors and readers, this journal provides supporting information supplied by the authors. Such materials are peer reviewed and may be re-organized for online delivery, but are not copy-edited or typeset. Technical support issues arising from supporting information (other than missing files) should be addressed to the authors. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
100,000,000 Guinea Pigs: Dangers in Everyday Foods, Drugs, and Cosmetics.
Authors: Arthur Kallet, F. J. Schlink
Journal: JAMA (1933)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Abstract 17466: Predictor of Long-term Atrial Fibrillation Recurrence Post Hybrid-MAZE Procedure: Five-Year Outcomes
Authors: Albert Chiu, Muhanad Al-Zubaidi, Kenith Fang, wilber Su
Journal: Circulation (2014)

Introduction:  Minimally invasive surgical (MIS) MAZE has an important role in the treatment of atrial fibrillation (AF). Intra-operative EP techniques during the MIS MAZE surgery enhance lesion efficacy, and are associated with acceptable safety and short-term success as previously described. This case series demonstrates persistent success rates at five year follow up from novel hybrid MIS MAZE.   Methods:  32 consecutive patients (mean age 68, mean left atrial size 6.6 cm) with symptomatic long-standing persistent AF underwent MIS MAZE with intraoperative electrophysiologic evaluation of acute lesion efficacy. Surgical pulmonary vein isolation and bi-atrial extended lesion sets were performed using the Aticure® system. Electrogram recording was performed by closely spaced electrode catheter placed epicardially by the surgeon at regions of interest as directed by the electrophysiologist. Post-ablation EP study and assessment of conduction block with differential pacing and arrhythmia induction were performed. Follow up was performed according to Heart Rhythm Society guidelines and then bi-annually after first year.   Results:  More than 84% of patients were able to maintain normal sinus rhythm at 1-year follow-up. At 5-year follow-up, 6 patients were lost to follow-up after 2 years, and 2 deaths unrelated to atrial fibrillation. Only 6 of 24 (18%) patients maintained normal sinus rhythm at five year. Of the 18 AF recurrences, LA size was 6.3cm. 16 of 18 patients have hypertension, 14 of 18 patients have diabetes, 12 of 18 have Class III congestive heart failure with an average EF of 38%, and 8 of 18 has obstructive sleep apnea. Of the 6 patients free from AF after 5 years, there was no congestive heart failure, sleep apnea, 2 of 6 has hypertension and 1 of 6 has diabetes.   Conclusions:  Extensive bi-atrial modification with hybrid MIS MAZE has improved short-term success rates when compared to ablation or surgical procedures alone with maintenance of normal sinus rhythm for the initial year. However, long-term freedom from atrial fibrillation is limited at 5 years. Avoidance and control of potential exacerbating factors may improve long-term outcome.
Abstract 1209: Interleukin-6 Reduces Myocardial Glucose Metabolism by Altering AMPK, Insulin Signaling, and PKC-𝛉 in Mice
Authors: Zhiyou Zhang, Hwi Jin Ko, Dae Young Jung, Zhexi Ma, Jason K Kim
Journal: Circulation (2007)

Increasing evidence implicates the role of inflammation in the pathogenesis of diabetes and complications. Inflammatory cytokines (IL-6, TNF-α) are elevated in obese diabetic subjects, and are shown to modulate glucose metabolism in peripheral organs. In this report, we examined the effects of IL-6 on cardiac metabolism and insulin action in vivo. Male C57BL/6 mice were intravenously treated with IL-6 (16 ng/hr) or saline (control) for 2 hrs, and [ 14 C]2-deoxyglucose was intravenously injected in awake mice to measure myocardial glucose metabolism (n=9~10). Hyperinsulinemic-euglycemic clamps (2.5 mU/kg/min insulin infusion) were also performed in IL-6 or saline-treated mice (n=4~5) to measure cardiac insulin action. Acute treatment with IL-6 caused a 25% increase in myocardial STAT3 activity and significantly reduced basal myocardial glucose metabolism (Fig. 1 ; * P&lt; 0.05). IL-6 treatment also reduced insulin-stimulated glucose uptake in heart, and these effects were associated with marked decreases in AMPK activity (Thr-phosphorylation of AMPK; Fig. 2 ) and IRS-1 tyrosine phosphorylation (Fig. 3 ). Acute IL-6 treatment increased myocardial expression of PKC-𝛉, which has been shown to mediate insulin resistance in peripheral organs (Fig. 4 ). These results indicate that IL-6 is a potent negative regulator of myocardial glucose metabolism and insulin action, and the underlying mechanism may involve IL-6 mediated activation of PKC-𝛉 and defects in AMPK and insulin signaling activity. Thus, our findings suggest a potential role of IL-6 in the pathogenesis of diabetic heart failure.
Second-Line Agents in the Treatment of Rheumatic Diseases
Authors: Jonathan S. Dixon, Daniel E. Furst
Journal: Annals of Internal Medicine (1992)

Part 1 Evaluation and use of second-line agents: distinction between NSAIDs, corticosteroids and second-line agents, J.P. Famaey variable disease and variable response to second-line agents, G. David Champion and Malcolm L. Handel problems in the design and interpretation of trials of second-line agents, Ken J. Bulpitt and Harold E. Paulus assessment procedures for monitoring second-line agents, Paul W. Thompson predictors of risk from the use of second-line agents in rheumatoid arthritis, Alan J. Silman decision making - the choice of second-line agents in the United States, Bonnie Hepburn decision making - the choice of second-line agents in Europe and the United Kingdom, T. Pullar decision making - the choice of second-line agents in Australia, P.M. Brooks et al comments on decision making - the choice of second-line agents, Daniel E. Furst. Part 2 Second-line agents in the treatment of rheumatoid arthritis: gold therapy - a choice in the 1990s, H.A. Capell and H. Torley penicillamine, J.K. van der Korst and A.O. Muijsers purine analogs, Robert J.R. McKendry antimalarials, R.I. Rynes sulfonamides, Deborah E. Bax methotrexate, D. Mathers and A.S. Russell cyclosprin, W.B. Harrison alkylating agents, P.J. Clements. Part 3 Second-line agents in the treatment of other arthritides: second-line agents in osteoarthritis, Peter Ghosh et al treatment of seronegative polyarthritis, V. Neumann and V. Wright second-line agents in systemic lupus erythematosus, Mary Betty Stevens and Carol M. Ziminski second-line treatment of crystal-induced synovitis, J.T. Scott second-line agents in the treatment of systemic vasculitis, A.S.M. Jawad and D.G.I. Scott. Part 4 Second-line agents in the future: combination chemotherapy for rheumatoid arthritis, P.T. Dawes and M.J. Davis trace element supplements for inflammatory disease, M.W. Whitehouse new immunosuppressive agents, immune modulators and other drugs, Alan J. Lewis and Richard P. Carlson.
Abstract 15100: Inhibition of P38 Mapk Improves Heart Function in Sustained Pressure-overload Induced Right Ventricular Hypertrophy and Failure
Authors: Baktybek Kojonazarov, Tatyana Novoyatleva, Zaneta Sabiska, Wiebke Janssen, Xia Tian, Himal Luitel, Philipp Kriechling, Julia Newman, Steven Evans, Friedrich Grimminger, Norbert Weissmann, Hossein Ardeschir Ghofrani, Werner Seeger, Ralph Theo Schermuly
Journal: Circulation (2014)

Introduction: The p38 mitogen-activated protein kinases (MAPK) considered as a key signaling pathway that responds to varied stresses, including those that contribute to heart failure. However, the role of p38 MAPK in pulmonary vascular and right ventricular remodeling is still need to be elucidated. Methods: The effects of p38 MAPK inhibitor PHA-00797804 (Pfizer, USA) investigated in mice subjected either to hypoxia-induced PH or to pulmonary artery banding (PAB). After 21 days, mice exposed to hypoxia were randomized and treated by vehicle or 5 mg/kg bw PHA-00797804 for 14 days. PAB mice were treated by vehicle or PHA-00797804 in a dose 5 mg/kg bw from day 7 to 21. The echocardiography, invasive hemodynamic measurement and hitomorphometry were performed. The myocardin-related transcription factor (MRTF) translocation and stress fibers formation were determined by immunofluorescence staining on isolated mouse cardiac fibroblasts. Results: The 38αMAPK inhibition significantly reversed pulmonary vascular remodeling and improved RV functions in hypoxia-induced PAH. However, to determine whether the effect in hypoxic mice was due to a direct impact of pharmacological interventions on RV or an indirect impact due to reduced pulmonary vascular resistance, we have investigated the effects of p38 MAPK inhibition in an established model of RVH and failure by PAB. The PHA-00797804 significantly increased cardiac output (p&lt;0.001), tricuspid annular plane systolic excursion (p&lt;0.001) and improved myocardial performance index (p&lt;0.001) in PAB mice. Improvement in RV functions was associated with strong antifibrotic effect of PHA-00797804. The p38 MAPK inhibition reduced collagen synthesis and myofibroblast differentiation via MRTF A dependent mechanism. Conclusion: Inhibition of p38 MAPK improved RV remodeling and function in experimental models of RV hypertrophy and failure.
Fatal Degenerative Neurologic Illnesses in Men Who Participated in Wild Game Feasts—Wisconsin, 2002
Authors: J. P. Davis, J. Kazmierczak, M. Wegner, R. Wierzba, P. Gambetti, L. Schonberger, R. Maddox, E. Belay, V. Hsu
Journal: JAMA (2003)

Fatal Degenerative Neurologic Illnesses in Men Who Participated in