tbuckley/cabot-search huggingface dataset:
Anti-inflammatory Intervention in Depression
Authors: Rebecca Anglin, Paul Moayyedi, Grigorios I. Leontiadis
Journal: JAMA Psychiatry (2015)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Psychiatry HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Psychiatry journal
Stimulants and Attention-Deficit/Hyperactivity Disorder—Reply
Authors: Timothy E. Wilens, Stephen V. Faraone, Joseph Biederman
Journal: JAMA (2004)

To the Editor: The Contempo Update on attention-deficit/ hyperactivity disorder (ADHD) by Dr Wilens and colleagues presented pharmacologic treatment options. However, in discussing the use of stimulant medications, the authors did not address risks of addiction, tolerance, or habituation. I would like to know if the authors think that these risks are significant enough to warrant having patients sign a treatment contract acknowledging the risks and the conditions of ongoing care. I would also be interested in whether they think patients receiving stimulant treatment should be evaluated monthly in the office prior to refills and, if not, what other refill mechanisms they would recommend.
Survival after diagnosis of AIDS: a prospective observational study of 2625 patients
Authors: A. Mocroft, M. Youle, J. Morcinek, C. A Sabin, B. Gazzard, A. N Phillips, M. Johnson
Journal: BMJ (1997)

<h3>Abstract</h3> <b>Objective:</b> To estimate median survival and changes in survival in patients diagnosed as having AIDS. <b>Design:</b> Prospective observational study. <b>Setting:</b> Clinics in two large London hospitals. <b>Subjects:</b> 2625 patients with AIDS seen between 1982 and July 1995. <b>Main outcome measures:</b> Survival, estimated using lifetable analyses, and factors associated with survival, identified from Cox proportional hazards models. <b>Results:</b> Median survival (20 months) was longer than previous estimates. The CD4 lymphocyte count at or before initial AIDS defining illness decreased significantly over time from 90x10<sup>6</sup>/l during 1987 or earlier to 40x10<sup>6</sup>/l during 1994 and 1995 (P&lt;0.0001). In the first three months after diagnosis, patients in whom AIDS was diagnosed after 1987 had a much lower risk of death (relative risk 0.44, 95% confidence interval 0.22 to 0.86; P=0.017) than patients diagnosed before 1987. When the diagnosis was based on oesophageal candidiasis or Kaposi9s sarcoma, patients had a lower risk of death than when the diagnosis was based on <i>Pneumocystis carinii</i> pneumonia (0.21 (0.07 to 0.59), P=0.0030 and 0.37 (0.16 to 0.83), P=0.016). Three months after AIDS diagnosis, the risk of death was similar in patients whose diagnosis was made after and before 1987 (1.02 (0.79 to 1.31), P=0.91). There were no differences in survival between patients diagnosed during 1988-90, 1991-3, or 1994-5. <b>Conclusions:</b> In later years, patients were much more likely to survive their initial illness, but long term survival has remained poor. The decrease in CD4 lymphocyte count at AIDS diagnosis indicates that patients are being diagnosed as having AIDS at ever more advanced stages of immunodeficiency. <h3>Key messages</h3> Estimates of the prognosis of AIDS patients help with allocation of resources and future research Historically, surveillance data have been used to estimate survival in large patient groups In an unselected group of 2625 patients with AIDS, median survival (20 months) was longer than previously estimated; the CD4 count at diagnosis decreased significantly over time After 1987, patients were much more likely to survive an initial AIDS defining illness, but long term prognosis remained poor There has been little change in prognosis since 1987; this may be due to AIDS being diagnosed at ever more advanced stages of immunodeficiency
Abstract 13456: Echocardiographic Estimation of Myocardial Scar by Segmental Longitudinal Strain in Patients with Ischemic Cardiomyopathy and Left Bundle Branch Block: Comparison with Quantitative Cardiac Magnetic Resonance Imaging Late Gadolinium Enhancement
Authors: Bhupendar Tayal, Niels Risum, Antonia Delgado-Montero, Allan Iversion, Thomas F Hansen, John Gorcsan, Peter Søgaard
Journal: Circulation (2014)

Introduction: Determination of myocardial scar is of great clinical importance in patients with ischemic cardiomyopathy (ICM) but conventional echocardiography methods are limited and left bundle branch block (LBBB) is problematic. The objective of this study was to utilize myocardial deformation imaging by two-dimensional (2D) speckle tracking echocardiography (STE) to estimate scar in patients with ICM and LBBB in comparison to quantitative assessment by cardiac magnetic resonance (CMR) late gadolinium enhancement (LGE). Methods: Transthoracic echocardiography was performed on 25 patients aged 74±8 years with ischemic cardiomyopathy (mean ejection fraction 28±8) and LBBB. Segmental longitudinal strain was measured by STE from three standard apical views with 6 segments per view. A 16 segment model was used with averaging of apical segments. Extent of segmental scar was quantified by contrast enhanced CMR and expressed in percentage of segmental LGE in all patients. Results: Feasibility for assessment of...
Mutations in PTPN11, encoding the protein tyrosine phosphatase SHP-2, cause Noonan syndrome
Authors: Marco Tartaglia, Ernest L. Mehler, Rosalie Goldberg, Giuseppe Zampino, Han G. Brunner, Hannie Kremer, Ineke van der Burgt, Andrew H. Crosby, Andra Ion, Steve Jeffery, Kamini Kalidas, Michael A. Patton, Raju S. Kucherlapati, Bruce D. Gelb
Journal: Nature Genetics (2001)
Abstract 4199: Riluzole modulates the production of exosomes in melanoma cells
Authors: Allison L. Isola, Yvonne Wen, James Goydos, Suzie Chen
Journal: Cancer Research (2014)

Abstract Exosomes are naturally occurring small membrane enclosed microvesicles generated constitutively and released by various cell types and more frequently released by tumor cells. It was postulated that exosomes may facilitate communication within the local microenvironment and the primary tumor, supporting melanoma cell dissemination and early events in metastasis. A gain-of-function mutation of a neuronal receptor, metabotropic glutamate receptor 1 (GRM1), when ectopically expressed in melanocytes, was sufficient to induce in vitro melanocytic transformation and spontaneous malignant melanoma development in vivo in a transgenic mouse model. Normal mouse melanocytes transformed with an expression vector containing GRM1 showed production and secretion of exosomes confirmed by electron microscopy, while the parental normal melanocytes showed no detectable presence of exosomes. In light of this data, It was hypothesized that over-expression of GRM1 in melanoma cells normally expressing a moderate amount of the protein, may promote elevated levels of exosome formation, while inhibitors to the receptor or limiting the levels of available ligand may suppress exosome production. Preliminary results demonstrated the working hypothesis is correct. Our earlier studies showed that inhibitors of the receptor modulated GRM1-mediated signaling events interfere with downstream effectors resulting in a decrease in both cell proliferation in vitro and tumor progression in vivo. It is not known if GRM1 acts directly, via its signaling cascade, or by another route, on exosome production regulation, this will be investigated. In addition to the pharmacological inhibitors we will also use a genetic approach with silencing RNA to modulate GRM1 expression levels. Citation Format: Allison L. Isola, Yvonne Wen, James Goydos, Suzie Chen. Riluzole modulates the production of exosomes in melanoma cells. [abstract]. In: Proceedings of the 105th Annual Meeting of the American Association for Cancer Research; 2014 Apr 5-9; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2014;74(19 Suppl):Abstract nr 4199. doi:10.1158/1538-7445.AM2014-4199
Abstract 15650: Nutritional Support With Medium Chain Fatty Acids During Extracorporeal Membrane Oxygenation in Infant Swine Model
Authors: Masaki Kajimoto, Dolena R Ledee, Nancy G Isern, Christine Des Rosiers, Michael A Portman
Journal: Circulation (2014)

Background: Extracorporeal membrane oxygenation (ECMO) is the most frequently used mechanical circulatory support in children with cardiopulmonary failure. Nutritional energy support as well as inotropic support is important to recover cardiac function during ECMO. Fatty acids (FAs) are major myocardial energy source for citric acid cycle (CAC). Medium-chain FAs (MCFAs) are easily uptaken into cell and mitochondria without membrane transporters. Our previous animal study suggested that MCFAs can potentially use for myocardial energy metabolism as the best accessible substrates during ECMO. Even-numbered MCFAs enter into CAC via acetyl-CoA, while odd-numbered MCFAs are anaplerotic for the CAC as propionyl-CoA in addition to acetyl-CoA. This study assessed whether odd- or even-numbered MCFAs product efficient energy during a short-term ECMO. Methods: Fifteen male Yorkshire pigs (26-45 days old) with 8-hour ECMO were received either normal saline, heptanoate (odd-numbered MCFA) or octanoate (even-numbered MCFA) at 2.3 μmol/kg body wt/min as MCFAs systemically during ECMO (n = 5 per group). The 13-Carbon ( 13 C) labeled substrates ([2- 13 C]lactate, [5,6,7- 13 C 3 ]heptanoate and [U- 13 C 6 ]leucine) as metabolic markers were infused into coronary artery for the final hour before left ventricular tissue extraction. Extracted left ventricular tissues were analyzed for the 13 C-labeled and absolute concentrations of metabolites by nuclear magnetic resonance and gas chromatography-mass spectrometry. Results: There were no adverse events in any groups during experiments. Octanoate produced markedly high citrate concentration, indicating the conjugation of CAC, and led to high [ATP]/[ADP] ratio compared with other groups (6.2 ± 0.6, 6.0 ± 0.6 and 7.8 ± 0.5 in normal saline, heptanoate and octanoate, P &lt; 0.05). Octanoate strongly increased the CAC metabolism through anaplerotic pathway from propionyl-CoA, but not heptanoate. Lactate oxidation and protein synthesis ratio from leucine were not different among 3 groups. Conclusions: Even-numbered MCFAs was superior energy source for CAC than odd-numbered MCFAs in normal heart supported with ECMO. These results support that nutritional therapy with even-numbered MCFAs facilitates weaning from ECMO.
Abstract 14416: Relationship between Society of Thoracic Surgeons Score and Logistic EuroSCORE Predicting the Mortality Risk in Patients Referred for Trans-Catheter Aortic Valve Implantation
Authors: Itsik Ben-Dor, Michael A. Gaglia, Manuel A. Gonzalez, Kohei Wakabayashi, Gabriel Maluenda, Asmir Syed, Mali Mahmoudi, Sera Collins, Loic Belle, Rebecca Torguson, Okubagzi Petros, Zhenyi Xue, William O. Suddath, Kenneth M. Kent, Joseph Lindsay, Lowell F. Satler, Augusto D. Pichard, Ron Waksman
Journal: Circulation (2010)
The Three-Fingered Cashier
Authors: Gary Stein
Journal: JAMA (2004)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Abstract 17625: Modeling the Long QT Syndrome with Human Induced Pluripotent Stem Cells
Authors: Ilanit Itzhaki, Leonid Maizels, Irit Huber, Limor Zwi, Amira Gepstein, Gil Arbel, Monther Boulos, Lior Gepstein
Journal: Circulation (2010)

The development of strategies to generate patient specific human induced pluripotent stem cells (hiPSCs) offers a new paradigm for modeling human disease and individualized drug testing. The congen...
Blocking TWEAK-Fn14 interaction inhibits hematopoietic stem cell transplantation-induced intestinal cell death and reduces GVHD
Authors: Martin Chopra, Andreas Brandl, Daniela Siegmund, Anja Mottok, Viktoria Schäfer, Marlene Biehl, Sabrina Kraus, Carina A. Bäuerlein, Miriam Ritz, Katharina Mattenheimer, Stefanie Schwinn, Axel Seher, Thomas Grabinger, Hermann Einsele, Andreas Rosenwald, Thomas Brunner, Andreas Beilhack, Harald Wajant
Journal: Blood (2015)
Cysteinyl‐leukotrienes contribute to sputum eosinophil chemotactic activity in asthmatics
Authors: L. Hemelaers, M. Henket, J. Sele, F. Bureau, R. Louis
Journal: Allergy (2005)

Background: Cysteinyl‐leukotrienes are lipid derived mediators involved in asthma. They are able to stimulate eosinophil chemotaxis in vitro. Induced sputum from asthmatics has been shown to contain eosinophil chemotactic activity. The purpose of our study was to evaluate the contribution of cysteinyl‐leukotrienes to sputum eosinophil chemotactic activity in asthmatics and to seek whether there might be differences between asthmatics free of inhaled corticosteroids vs those regularly receiving this treatment. Methods: Twenty‐two patients (11 corticosteroid free, mean FEV 1 99% predicted, 11 corticosteroid‐treated, mean FEV 1 77% predicted) recruited from our asthma clinic underwent a sputum induction. Sputum was processed according to standard procedure. Eosinophil chemotactic activity contained in the fluid phase was assessed using Boyden microchamber model and expressed as chemotaxis index (CI). Cysteinyl‐leukotrienes were measured in sputum supernatant by ELISA and their role in sputum eosionophil chemotactic activity was evaluated by using montelukast, a selective antagonist of a cys‐LT1 receptor. Results: Cysteinyl‐leukotrienes were well detectable in sputum supernatants from both steroid‐naive (247 ± 42 pg/ml) and steroid‐treated (228 ± 26 pg/ml) asthmatics. Sputum eosinophil chemotactic activity was indiscriminately present in both corticosteroid‐naive (CI: 2.61 ± 0.22) and corticosteroid‐treated (2.98 ± 0.35) asthmatics. Montelukast (100 μ M) significantly inhibited the eosinophil chemotactic activity in both groups achieving a mean inhibition of 54.2 ± 9.2% ( P &lt; 0.001) and 64.7 ± 7.8% ( P &lt; 0.001) in steroid‐naive and steroid‐treated asthmatics respectively. Conclusion: Cysteinyl‐leukotrienes actively participate in sputum eosinophil chemotactic activity found in asthmatics irrespective of whether they are or not under treatment with inhaled corticoids.
A cell-based model of pathological tau uptake and propagation
Authors: Ben Falcon, Rachel Angers, Michel Goedert
Journal: Molecular Neurodegeneration (2013)

Background Increasing cognitive impairment and neuronal loss correlate with the spread of tau inclusions through the brain. When present in large quantities, these inclusions contribute to Alzheimer’s disease and other neurodegenerative diseases termed tauopathies. [1]. More recently, experiments both in vitro and in vivo have observed that pathological tau can transfer between cells and transmit a misfolded state to cytosolic soluble tau [2]. We have developed a cell-based model to dissect the mechanisms behind the propagation of tau pathology and assess potential therapeutic strategies.
Reply
Authors: Katharina Mayer, Isabell Bernlochner, Siegmund Braun, Stefanie Schulz, Martin Orban, Tanja Morath, Lisena Cala, Petra Hoppmann, Heribert Schunkert, Karl-Ludwig Laugwitz, Adnan Kastrati, Dirk Sibbing
Journal: Journal of the American College of Cardiology (2015)
No clinical benefit of preoperative fluorescence diagnosis of basal cell carcinoma localized in the H-zone of the face
Authors: T. Wetzig, M. Kendler, J. Maschke, U. Paasch, J.C. Simon
Journal: British Journal of Dermatology (2010)

Basal cell carcinoma (BCC) is the most common malignant skin carcinoma. Fluorescence diagnosis (FD) has been suggested as a promising method for noninvasive detection of subclinical tumour cell dissemination in BCC.In this prospective study, we evaluated the clinical performance of a preoperative definition of the lateral borders of BCC by FD in comparison with its definition by purely clinical diagnosis (CD). The fluorescence intensity on the skin was recorded using a digital light-emitting diode-based fluorescence imaging system.Twenty-six patients with BCC (22 with nodular subtype) of the H-zone were included. The tumour area was determined 3 h after application of methyl aminolaevulinate by inspection and photographic documentation (CD) and FD. Subsequently, BCCs were excised according to the complete area defined by CD and FD with a security margin of 3 mm; surgical specimens were sectioned horizontally and subjected to meticulous histological mapping. The tumour areas as determined by FD, CD and histology were superimposed to map the entire lateral tumour margin.The tumour area could be visualized by FD in 24 of 26 patients. The mean tumour area as determined by FD was significantly smaller than the tumour area as determined by CD [80 mm(2) , 95% confidence interval (CI) 50-110 mm(2) vs. 101 mm(2) , 95% CI 76-125 mm(2) ; P < 0·012]. The superimposition of FD and histology showed in 10 of 26 patients a complete detection of the tumour margin by FD; thus sensitivity of FD was calculated as 38·5%. In only three of 26 patients FD revealed a tumour extent greater than determined by CD. Specificity of FD was calculated as 88·4%.On aggregate, this study suggests that preoperative FD of nodular BCC localized in the H-zone offers no additional benefit to define subclinical tumour infiltration compared with CD alone.
Identification of apolipoprotein C-1 as a novel prognostic serum marker of pancreatic cancer and its expression in cancer cells
Authors: Shigetsugu Takano, Hideyuki Yoshitomi, Kazuyuki Sogawa, Fumio Kimura, Hiroaki Shimizu, Hiroyuki Yoshidome, Masayuki Otsuka, Takeshi Tomonaga, Fumio Nomura, Masaru Miyazaki
Journal: Clinical Cancer Research (2006)

A55  Pancreatic cancer still remains one of the most lethal diseases with increasing incidence and establishment of new therapy is needed. The purpose of this study is to find novel serum factors involved in pancreatic cancer development, by protein profiling using surface-enhanced laser desorption ionization time-of-flight mass spectrometry (SELDI-TOF-MS) and ProteinChip analysis.For this purpose, we compared pre- and postoperative serum protein profiling obtained from patients with pancreatic cancer. Samples from twenty patients who underwent curative pancreatectomy were analyzed. Clusters of 85 peaks were differentially expressed in pre- and postoperative serum of pancreatic cancer patients, and proteins with 6630 Da and 6420 Da m/z peaks were candidates for pancreatic cancer-specific proteins as more abundantly expressed in preoperative serum than in postoperative serum (p
Surgical Diseases of the Pancreas.
Authors: John M. Howard
Journal: Annals of Internal Medicine (1961)

Foundations of clinical practice pre-operative approaches to pancreatic disease intraoperative diagnostic procedures special considerations acute pancreatitis chronic pain special forms of pancreatitis tumours of the exocrine pancreas clinical management of carcinoma of the exocrine pancreas other pancreatic tumours, clinical management adjacent tumours requiring pancreatic resection or related operations true cysts and cystic tumours of the pancreas the endocrine pancreas special problems.
Practical Management of the Elderly.
Authors: Anderson, W. Ferguson , Sir
Journal: Annals of Internal Medicine (1971)

Old age The preventive approach Problems in diagnosis Drug therapy Gastrointestinal diseases Heart disease Disorders of blood pressure Respiratory diseases Blood diseases Endocrine disease Diseases of the kidney and prostrate Diseases of the bladder and urinary incontinence Stroke Other common neurological disorders Mental disorders Musculoskeletal disorders Accidental hypothermia Nutrition Eye diseases Skin diseases Care of the dying Organization of a geriatric service. Appendixes : Services available for old people Training of physicians in geriatric medicine Useful addresses American drugs equivalent to those mentioned in text.
Where We Live
Authors: Issam Zineh
Journal: JAMA (2000)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal