TREATMENT OF CARDIOVASCULAR SYPHILIS
Authors: H EISENBERG
Journal: Annals of Internal Medicine (1948)

Article1 July 1948TREATMENT OF CARDIOVASCULAR SYPHILISH. EISENBERG, M.D.H. EISENBERG, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-29-1-71 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptINTRODUCTIONCardiovascular syphilis is frequently a problem to the internist. Ten to 15 per cent of cases of recognized cardiovascular disease, Blumgart1has estimated, are due to syphilis. Statistical studies by Moore2and by Leiby and Callaway and their coworkers3indicate that there are approximately 240,000 patients with syphilitic cardiovascular disease in this country at any one time and between 20 and 30 thousand die annually from it. Since the time of Ehrlich, the treatment of this disease has been a controversial matter, and remains so today notwithstanding the widespread and effective use of penicillin in therapy of early syphilis....Bibliography1. BLUMGART HL: Detection and treatment of cardiovascular syphilis, New England Jr. Med., 1940, ccxxiii, 443. CrossrefGoogle Scholar2. MOOREDANGLADEREISINGER JEJHJC: Diagnosis of syphilitic aortitis uncomplicated by aortic regurgitation of aneurysm, Arch. Int. Med., 1932, xlix, 753. CrossrefGoogle Scholar3. LEIBYCALLAWAYFLEMING GMJLWL: Diagnosis and management of asymptomatic uncomplicated aortitis, North Carolina Med. Jr., 1940, i, 301. Google Scholar4. LONGCOPE WT: Syphilitic aortitis, its diagnosis and treatment, Arch. Int. Med., 1913, xi, 15. CrossrefGoogle Scholar5. WARTHIN AS: The lesions of latent syphilis, Southern Med. Jr., 1931, xxiv, 273. CrossrefGoogle Scholar6. LANGER E: Die Haufigkeit der luetischen Organveranderungen, insbesondere der Aortitis luetica, Munchen. med. Wchnschr., 1926, lxxiii, 1782. Google Scholar7. STOKES JH: Modern clinical syphilology, 1944, W. B. Saunders Co., Philadelphia, p. 900. Google Scholar8. LUCKÉREA BE: in STOKES J. H.: Modern clinical syphilology, 1944, W. B. Saunders Co., Philadelphia, p. 896. Google Scholar9. MOORE JE: See reference 2 above. Google Scholar10. BRUUSGAARD E: Summary of Bruusgaard's data as to ultimate outcome of untreated syphilis. From MOORE J. E.: Modern treatment of syphilis, 1943, Charles C. Thomas, Springfield, Ill., p. 38. Google Scholar11. COLEUSILTON HNLJ: Cooperative clinical group; studies in the treatment of syphilis, Ven. Dis. Inform., 1936, xvii, 95. Google Scholar12. TURNER TB: In STOKES J. H.: Modern clinical syphilology, 1944, W. B. Saunders Co., Philadelphia, p. 896. Google Scholar13. CARR JG: The gross pathology of the heart in cardiovascular syphilis, Am. Heart Jr., 1930, vi, 30. CrossrefGoogle Scholar14. BROOKS H: The treatment of cardiovascular syphilis, Warthin Anniversary Volume, Wehr, Ann Arbor, 1927, p. 117. Google Scholar15. STOKES JH: Modern clinical syphilology, 1944, W. B. Saunders Co., Philadelphia, p. 907. Google Scholar16. DRESSLER M: Cardiovascular syphilis; an approach to early clinical recognition and early treatment, Conn. State Med. Jr., 1945, ix, 848. Google Scholar17. MAYNARD EP: Diagnosis of cardiovascular syphilis, Brooklyn Hosp. Jr., 1940, ii, 69. Google Scholar18. WILSON R: Studies in syphilitic cardiovascular disease. I. Uncomplicated syphilitic aortitis; an asymptomatic condition, Am. Jr. Med. Sci., 1937, cxciv, 178. CrossrefGoogle Scholar19. : In STOKES J. H.: Modern clinical syphilology, 1944, W. B. Saunders Co., Philadelphia, p. 931. Google Scholar20. THOMPSONCORNEAUWHITE WPWJPD: The role of the treatment of syphilis in the prevention of cardiovascular involvement, Am. Heart Jr., 1939, xvii, 286. CrossrefGoogle Scholar21. Private communication to author. Google Scholar22. REID WD: The mechanism of the toxic action of arsphenamine on the heart, Jr. Am. Med. Assoc., 1925, lxxxiv, 883. CrossrefGoogle Scholar23. WILE UJ: The treatment of the syphilitic liver and heart, a therapeutic paradox, Am. Jr. Med. Sci., 1922, clxiv, 415. CrossrefGoogle Scholar24. SCHOTTMULLER H: On the treatment of syphilis of the aorta, Am. Jr. Syph., 1925, ix, 1. Google Scholar25. MOORE JE: The modern treatment of syphilis, 1943, Charles C. Thomas, Springfield, Illinois, p. 294. Google Scholar26. : The treatment of early syphilis with penicillin, Jr. Am. Med. Assoc., 1946, cxxxi, 265. Google Scholar27. MOORE JE: Penicillin in syphilis, 1947, Charles C. Thomas, Springfield, Illinois, p. 195. Google Scholar28. RUSSEKCUTLERFROMERZOHMAN HIJCSABL: Treatment of cardiovascular syphilis with penicillin, Ann. Int. Med., 1946, xxv, 957-959. Google Scholar29. DOLKARTSCHWEMLEIN RLGX: The treatment of cardiovascular syphilis with penicillin, Jr. Am. Med. Assoc., 1945, cxxix, 515-516. CrossrefGoogle Scholar30. Private communication from E. E. Peters to author. Google Scholar31. To be published. Google Scholar32. WILE UJ: Cardiovascular syphilis, Rapid Treatment Center Bulletins, 1945, ii, 12. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Chicago, Illinois*Read at the postgraduate course on cardiovascular disease, Northwestern University Medical School, Chicago, Illinois, as arranged by the American College of Physicians, April 23, 1947.†Surgeon (R), U. S. Public Health Service.Under the direction of Herman N. Bundesen, Senior Surgeon (R) (Inactive), U. S. Public Health Service; President, Chicago Board of Health. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byPrevention of heart failureKrankheiten der GefäßePenicillin Treatment of Cardiovascular Syphilis 1 July 1948Volume 29, Issue 1Page: 71-78KeywordsCardiovascular diseasesMedical servicesPenicillinSurgeonsSyphilis ePublished: 1 December 2008 Issue Published: 1 July 1948 PDF downloadLoading ...