TOXICOLOGY AND ASSAY OF METHYLENE BLUE
Authors: David I. Macht, Wilton C. Harden
Journal: Annals of Internal Medicine (1933)

Article1 December 1933TOXICOLOGY AND ASSAY OF METHYLENE BLUEDAVID I. MACHT, M.D., F.A.C.P., WILTON C. HARDEN, PH.D.DAVID I. MACHT, M.D., F.A.C.P.Search for more papers by this author, WILTON C. HARDEN, PH.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-7-6-738 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptINTRODUCTIONMethylthionine chloride, or methylene blue, is recognized by the United States Pharmacopoeia but its administration has hitherto been only by mouth. Recently, however, considerable publicity has been given its intravenous use in cases of cyanide and carbon monoxide poisoning. This therapeutic application of the dye has been the direct result of the most interesting laboratory investigations of Matilda M. Brooks1,2,3,4 and clinical reports of J. C. Geiger.5,6The value of methylene blue in the treatment of cyanide poisoning has been described by earlier writers. Thus, Sahlin7demonstrated its antidotal action in 1926, and Eddy8,9also found that methylene blue...References1. BROOKS MM: Effect of methylene blue on CN and CO poisoning (preliminary report), Proc. Soc. Exper. Biol. and Med., 1932, xxix, 1228-1229. CrossrefGoogle Scholar2. BROOKS MM: Effect of methylene blue on HCN and CO poisoning, Am. Jr. Physiol., 1932, cii, 145-147. CrossrefGoogle Scholar3. BROOKS MM: Methylene blue as antidote to CO poisoning (preliminary report), Proc. Soc. Exper. Biol. and Med., 1933, xxx, 493-494. CrossrefGoogle Scholar4. BROOKS MM: Methylene blue as antidote to CO poisoning, Am. Jr. Physiol., 1933, civ, 139-141. CrossrefGoogle Scholar5. GEIGER JC: Cyanide poisoning in San Francisco, Jr. Am. Med. Assoc., 1932, xcix, 1944-1945. CrossrefGoogle Scholar6. GEIGER JC: Methylene blue solutions in treatment of carbon monoxide poisoning, Jr. Am. Med. 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Author, Article, and Disclosure InformationAffiliations: Baltimore, Maryland*Received for publication July 5, 1933.From the Chemical and Pharmacological Research Laboratories, Hynson, Westcott and Dunning, Inc., Baltimore, Maryland. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byMethylene blue as an inhibitor of superoxide generation by xanthine oxidaseThe crystallization and dissolution of sodium urateMethylene blue induced cyanosis and acutehemolytic anemia complicating the treatment of methemoglobinemiaMethämoglobinbildende GifteUntersuchungen über die Wirkung einiger Redoxyfarbstoffe bei Zuständen gestörter AtmungExperimentelle Studien zur Behandlung der Vergiftung durch Blausäure-Einatmung 1 December 1933Volume 7, Issue 6Page: 738-745KeywordsCarbon monoxideMethylene blueMouthResearch laboratoriesToxicology Issue Published: 1 December 1933 PDF downloadLoading ...