tbuckley/cabot-search huggingface dataset:
Abstract 408: Hematogenous metastasis in ovarian cancer: Importance of the ErbB3/NRG axis.
Authors: Sunila Pradeep, Kim Wook, Masato Nishimura, Pradeep Raghavan, Chad Pecot, Gabriel Lopez, Isaiah Fidler, Anil Sood
Journal: Cancer Research (2013)

Abstract Background: Ovarian cancer is predominantly thought to metastasize by intraperitoneal spread. Here, we report unexpected findings related to hematogenous ovarian cancer metastasis with strong tropism for the omentum. Study methods and results: To investigate the potential patterns of metastasis from circulating ovarian cancer cells, we established a novel parabiosis model, where 2 mice are surgically fused to allow a common circulation. Using this model, we found that ovarian cancer cells can indeed metastasize hematogenously and predominantly localize to the omentum. Cells propagated from this model are called SKOV3-OM3. To understand potential mechanisms, we carried out integrated genomic and human Phospho RTK arrays, which pointed to ErbB3/NRG1 as a dominant activated pathway. NRG1 stimulated migration (40%) and invasion (60%) of SKOV3-OM3 cells. NRG1 stimulation consistently induced downstream signaling pathways such as PI3K-AKT axis and Src activation in the cells with predilection for omental metastasis. We also showed that EMT modulating genes (eg. Vimentin and E-cadherin) are regulated by ErbB3 and PI3K in SKOV3-OM3 cells. In parallel approaches to determine the requirement of the ErbB3/NRG1 pathway for hematogenous metastasis of ovarian cancer to the omentum, both immune-deficient and immune-competent models were used. Upon intracardiac (IC) injection of SKOV3-OM3 cells (nude mice) and IG10-OM2 cells (C57BL/6 mice), tumor development and metastasis was followed by weekly luciferase imaging; tumors were harvested for histopathology and downstream molecular analyses. ErbB3 silencing using siRNA incorporated in DOPC nanoliposomes resulted in substantially decreased tumor growth and metastasis compared with control siRNA in both models (P &amp;lt;0.001). ErbB3 silencing resulted in significant reduction of proliferation and increase in apoptosis for both experiments. These data indicate that ErbB3 plays a functionally significant role in omental metastasis. Conclusion: This study provides a new paradigm regarding ovarian cancer metastasis in that ovarian cancer cells have a parallel path of spread to the omentum hematogenously. As such, these findings have significant clinical implications. Citation Format: Sunila Pradeep, Kim Wook, Masato Nishimura, Pradeep Raghavan, Chad Pecot, Gabriel Lopez, Isaiah Fidler, Anil Sood. Hematogenous metastasis in ovarian cancer: Importance of the ErbB3/NRG axis. [abstract]. In: Proceedings of the 104th Annual Meeting of the American Association for Cancer Research; 2013 Apr 6-10; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2013;73(8 Suppl):Abstract nr 408. doi:10.1158/1538-7445.AM2013-408
Legal and Medical Insanity
Authors: C. J. d. V. Shortt
Journal: BMJ (1946)

Evaluations of health care–based screening programs for social risks often report that a relatively small proportion of patients screening positive for social risk factors are interested in receiving assistance from their health care teams to address them. The relatively low number of patients who desire assistance is relevant to the growing number of initiatives in US health care settings designed to collect data on and address patients’ social risks. We highlight multiple studies that have found differences between positive risks screens and desire for assistance. We explore possible explanations for those differences—focusing on the fallibility of screening tools as well as patient preferences, priorities, and lived experiences—and the potential implications for health equity.
A 71 year old man with right sided facial droop
Authors: S. Saheecha, M. Monaghan, J. Reiken, L. Millar
Journal: BMJ (2011)

A 71 year old man noticed a right sided facial droop while shaving in the morning. When a neighbour visited shortly afterwards he had difficulty expressing himself. She called for an ambulance and he was taken to the accident and emergency department.

He had a history of amputation above the right knee for peripheral vascular disease, emphysema, and myocardial infarction.

His drugs included ramipril, simvastatin, and omeprazole. He was an ex-smoker of 50 pack years and drank alcohol occasionally. He lived alone and was independent in a wheelchair.

His blood pressure was 116/76 mm Hg and his pulse regular at 74 beats/min. His chest was clear and heart sounds normal. Neurological examination showed dysarthria with both an expressive and mild receptive dysphasia. He had right sided facial weakness with sparing of the forehead. Limb muscle tone was normal; muscle power was 3/5 grading in the right upper limb and normal in the left upper limb, left lower limb, and right stump.

Chest radiography showed cardiomegaly and electrocardiography (ECG) showed sinus rhythm, with poor R wave progression and widespread Twave inversion in leads V4-6 and leads II, III, and avF. Urgent computed tomography of the head showed a left middle cerebral artery infarct. He was given thrombolytic treatment within three hours of the onset of his symptoms. In view of the substantial changes on ECG, urgent echocardiography was performed the day after admission (fig 1⇓).





### 1 What does the echocardiogram show and what is the likely underlying cause?

#### Short answer

The echocardiogram shows a large inferolateral left ventricular aneurysm with a large volume of thrombus (fig 2⇓). The aneurysm is …
Time Course of Aortic Valve Function and Root Dimensions After Subcoronary Ross Procedure for Bicuspid Versus Tricuspid Aortic Valve Disease
Authors: Claudia Schmidtke, Matthias Bechtel, Michael Hueppe, Hans-H. Sievers
Journal: Circulation (2001)

The freestanding aortic root, which is the currently preferred operative technique for pulmonary autografts, is reported to dilate and potentially promote aortic insufficiency, which has led to a controversial debate on the appropriate surgical technique, especially for congenital bicuspid aortic valve disease. Desirable data on the time course of valve function and root dimensions for the alternative subcoronary technique comparing bicuspid and tricuspid aortic valve disease are scarce.Echocardiographic examinations of 31 patients with congenital bicuspid aortic valve disease (group A; age 50.5+/-11.0 years) and 51 patients with acquired tricuspid aortic valve disease (group B; age 48.1+/-15.7 years) who were operated on between June 1994 and August 1998 were performed twice postoperatively. At first and second follow-up, respectively, maximum (mean) pressure gradients were 6.0+/-2.0 (3.6+/-1.0) and 5.1+/-2.1 (2.9+/-1.1) mm Hg in group A and 6.5+/-3.5 (3.9+/-1.9) and 5.0+/-1.7 (2.9+/-1.0) mm Hg in group B (P>0.05 between groups). In group A, grade 0 aortic insufficiency at first and second follow-up occurred in 8 and 7 patients, respectively, grade 0-I in 12 and 9 patients, grade I in 9 and 11 patients, grade I-II in 1 and 0 patients, and grade II in 1 and 4 patients; in group B, grade 0 aortic insufficiency occurred in 16 and 18 patients, grade 0-I in 16 and 8 patients, grade I in 17 and 21 patients, grade I-II in 0 and 1 patient, and grade II in 0 and 1 patient (P>0.05). Aortic insufficiency decreased in 10 patients (17%). However, there was an overall tendency for aortic insufficiency to increase over time (n=23, 38%), although it remained subclinical. Aortic root dimensions did not differ between groups and were constant during follow-up.This study provides some evidence that the function of the subcoronary pulmonary autograft in bicuspid aortic valve disease is excellent, with stable root dimensions, and is not different from that of tricuspid aortic valves at least up to 5.5 years postoperatively, which suggests the subcoronary technique should be reconsidered.
Collagen content in different areas of normal and hypertrophied rat myocardium
Authors: I. MEDUGORAC
Journal: Cardiovascular Research (1980)

Journal Article Collagen content in different areas of normal and hypertrophied rat myocardium Get access IVAN MEDUGORAC IVAN MEDUGORAC * From the Physiologisches Institut der Universitat Tübingen, D-7400 Tübingen, Germany * Address for reprints: Dr I Medugorac, Physiologisches Institut der Universität, Tübingen, Lehrstuhl II (Prof Jacob), Gmelinstr. 5, D-7400 Tübingen, Germany. Search for other works by this author on: Oxford Academic PubMed Google Scholar Cardiovascular Research, Volume 14, Issue 9, September 1980, Pages 551–554, https://doi.org/10.1093/cvr/14.9.551 Published: 01 September 1980
Ulceration of the Fraenum Linguae in Pertussis
Authors: R. Cory
Journal: BMJ (1878)

THE following case is recorded with the object of drawing attention to a source of poisoning not commonly known, namely, the presence of a soluble form of arsenic in many of the sheets sold under the name of "fly-papers".A boy of eight years was admitted to Charity Ward, St. Thomas's Hospital, at 7.15 P.M. on the 18th May last, unconscious, and( to all appearance suffering from belladonna-poisoning. It was asserted that the symptoms had come on at about 5 P.l.; and, as the friends had already suspected poisoning, three explanations were offered by them for the information of the hospital officials.I.At 10o.30 Ax.M., the child had been challenged by his sister to drink the water from a plate in which a fly-paper was soaking.Hie was said to have drunk some: an example which was not followed by his sister.2. The sister was attending at the Royal South London Ophthalmic Hospital, ind had been there supplied with a green lotion for application to the eyes.This lotion, according to the mother's statement, was kept in a cupboard, and inaccessible to the child.It had been placed in the cupboard at 4.30, on her return from the hospital.The child had been strictly forbidden to touch this lotion.3. The friends of the patient were inclined to think that some sweet- meats of which the child had partaken in the afternoon were the vehicles of the poison.The history and symptoms were collected by Mr. Walter Tyrrell and Mr. W. H. Battle, house-physicians in the hospital.It appeared that towards 5 P.M., shortly after he had eaten some of the sweets mentioned, his mouth became dry.This led him to drink a quantity of water, which made him no better.Presently he began to feel giddy and to fall about, not knowing where he was.He dared not sit, on account of a fte'ing that he should tumble off from the chair; and he felt secure only in the kneeling posture.lIe had no pain, no vomiting, no diarrhoea.He became incoherent in his talk for the first time at 5 P. m , and soon after that symptoms of reten- tion of urine attracted attention.As he was rapidly becoming help- less, he was led or carried to a medical man, and passed on by his assistant to the hospital.By this time, 7 P. M., he was quite unconscious of what was passing around, not showing the least recognition of his mother; and he could not walk or stand.The pupils were extremely dilated, and insensible to light.The ophthalmoscope was used without the slightest s'.gn of annoyance to the patient.No abnormity was detected within the
Modulation of contractility in human cardiac hypertrophy by myosin essential light chain isoforms
Authors: Marcus C. Schaub, Martin A. Hefti, Richard A. Zuellig, Ingo Morano
Journal: Cardiovascular Research (1998)

Cardiac hypertrophy is an adaptive response that normalizes wall stress and compensates for increased workload. It is accompanied by distinct qualitative and quantitative changes in the expression of protein isoforms concerning contractility, intracellular Ca2+-homeostasis and metabolism. Changes in the myosin subunit isoform expression improves contractility by an increase in force generation at a given Ca2+-concentration (increased Ca2+-sensitivity) and by improving the economy of the chemo-mechanical transduction process per amount of utilised ATP (increased duty ratio). In the human atrium this is achieved by partial replacement of the endogenous fast myosin by the ventricular slow-type heavy and light chains. In the hypertrophic human ventricle the slow-type β-myosin heavy chains remain unchanged, but the ectopic expression of the atrial myosin essential light chain (ALC1) partially replaces the endogenous ventricular isoform (VLC1). The ventricular contractile apparatus with myosin containing ALC1 is characterised by faster cross-bridge kinetics, a higher Ca2+-sensitivity of force generation and an increased duty ratio. The mechanism for cross-bridge modulation relies on the extended Ala–Pro-rich N-terminus of the essential light chains of which the first eleven residues interact with the C-terminus of actin. A change in charge in this region between ALC1 and VLC1 explains their functional difference. The intracellular Ca2+-handling may be impaired in heart failure, resulting in either higher or lower cytosolic Ca2+-levels. Thus the state of the cardiomyocyte determines whether this hypertrophic adaptation remains beneficial or becomes detrimental during failure. Also discussed are the effects on contractility of long-term changes in isoform expression of other sarcomeric proteins. Positive and negative modulation of contractility by short-term phosphorylation reactions at multiple sites in the myosin regulatory light chain, troponin-I, troponin-T, α-tropomyosin and myosin binding protein-C are considered in detail.
State Trends in Health Risk Factors and Receipt of Clinical Preventive Services Among US Adults During the 1990s
Authors: David E. Nelson
Journal: JAMA (2002)

Monitoring trends is essential for evaluating past activities and guiding current preventive health program and policy efforts. Although tracking progress toward national health goals is helpful, use of national estimates is limited because most preventive health care activities, policies, and other efforts occur at the state or community level. There may be important state trends that are obscured by national data.To estimate state-specific trends for 5 health risk factors and 6 clinical preventive services.Telephone surveys were conducted from 1991 through 2000 as part of the Behavioral Risk Factor Surveillance System.Randomly selected adults aged 18 years or older from 49 US states. Annual state sample sizes ranged from 1188 to 7543.Statistically significant changes (P<.01) in state prevalences of cigarette smoking, binge alcohol use, physical inactivity, obesity, safety belt use, and mammography; screening for cervical cancer, colorectal cancer, and cholesterol levels; and receipt of influenza and pneumococcal disease vaccination.There were statistically significant increases in safety belt use for 39 of 47 states and receipt of mammography in the past 2 years for women aged 40 years or older for 43 of 47 states. For persons aged 65 years or older, there were increases in receipt of influenza vaccination for 44 of 49 states and ever receiving pneumococcal vaccination for 48 of 49 states. State trends were mixed for binge alcohol use (increasing in 19 of 47 states and declining in 3), physical inactivity (increasing in 3 of 48 states and declining in 11), and cholesterol screening (increasing in 13 of 47 states and decreasing in 5). Obesity increased in all states and smoking increased in 14 of 47 states (declining only in Minnesota). Cervical cancer screening increased in 8 of 48 states and colorectal cancer screening increased in 13 of 49 states. New York experienced improvements for 8 of 11 measures, while 7 of 11 measures improved in Delaware, Kentucky, and Maryland; in contrast, Alaska experienced improvements for no measures and at least 4 of 11 measures worsened in Iowa, North Dakota, and South Dakota.Most states experienced increases in safety belt use, mammography, and adult vaccinations. Trends for smoking and binge alcohol use are disturbing, and obesity data support previous findings. Trend data are useful for targeting state preventive health efforts.
Suprofen and Acute Renal Failure
Authors: NINA S. DAVIS
Journal: Annals of Internal Medicine (1986)

ExcerptTo the editor: In healthy unstressed humans or animals, renal function is not significantly affected by nonsteroidal anti-inflammatory drugs (1, 2). When acute renal failure occurs after use of one of these drugs, it is generally attributed to inhibition of prostaglandin synthesis or, less often, to acute interstitial nephritis (2, 3). We report a case of acute renal failure that occurred in a healthy man after a single dose of suprofen, a new proprionic acid derivative (4).A 47-year-old general surgeon, previously in good health and on no medications, took one 200-mg capsule of suprofen for treatment of a headache....
Image analysis of remesothelialization following chemical wounding of cultured human peritoneal mesothelial cells: The role of hyaluronan synthesis
Authors: Takashi Horiuchi, Keiichi Miyamoto, Sunao Miyamoto, Mika Fujita, Nami Sano, Kyoko Minamiyama, Yuichirou Fujimura, Koichi Nagasawa, Chie Otsuka, Yuji Ohta
Journal: Kidney International (2003)
The Red Kerchief: Portrait of Mrs Monet
Authors: Thomas B. Cole
Journal: JAMA (2010)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The ADR Numbers Game Revisited
Authors: John C. Ballin
Journal: JAMA (1975)

The numbers game on adverse drug reactions (ADRs) apparently has not run its course. We continue to witness wild public statements of purported morbidity and mortality caused by ADRs. As has already been pointed out, ADRs are an inevitable consequence of medical practice.<sup>1</sup>The aim of good therapy, therefore, is to decrease ADRs to the irreducible minimum. Yet, many critics of the medical profession seem to imply that, given a system of closer surveillance of therapeutics, the ADR problem could be eliminated altogether. As every physician knows, this is nonsense. A basic tenet of good scientific problem-solving is to identify the problem, determine its extent, and then advocate remedial measures. That a problem of preventable ADRs exists cannot be denied; the literature abounds with references to the prescription of the wrong drug or dose, to unforeseen drug interactions, or simply to the administration of a drug when none was
Dissecting cellulitis of the scalp: response to isotretinoin
Authors: L. SCERRI, H.C. WILLIAMS, B.R. ALLEN
Journal: British Journal of Dermatology (1996)

We report three patients with dissecting cellulitis of the scalp. Prolonged treatment with oral isotretinoin was highly effective in all three patients. Furthermore, long-term post-treatment follow-up in two of the patients has shown a sustained therapeutic benefit.
Brucellosis and the British Tourist Industry.
Authors: E Williams
Journal: BMJ (1971)

45smaller area health authorities, but could not, and should not these be based on existing district general hospital areas?Both the general public and those providing medical services to them would do well to challenge the loss of local involvement implicit in this new paper.Management can only be truly effective when it involves those at the grass roots.At all events, let everyone think about the problem and do as we have done-pass on their opinions to the Secretary of State for Social Services and to the B.M.A., so that they may have a consolidated opinion on which to work.The Government is in a hurry, so think now, for as Samuel Richardson said "Advice comes too late when a thing is done."-Weare, etc.,
Targeting calcium transport in ischaemic heart disease
Authors: M.A. H. Talukder, J. L. Zweier, M. Periasamy
Journal: Cardiovascular Research (2009)

Ischaemic heart disease (IHD) is the leading cause of morbidity and mortality worldwide. While timely reperfusion of acutely ischaemic myocardium is essential for myocardial salvage, it leads to a unique type of injury known as 'myocardial ischaemia/reperfusion (I/R) injury'. Growing evidence suggests that a defect in myocardial Ca2+ transport system with cytosolic Ca2+ overload is a major contributor to myocardial I/R injury. Progress in molecular genetics and medicine in past years has clearly demonstrated that modulation of Ca2+ handling pathways in IHD could be cardioprotective. The potential benefits of these strategies in limiting I/R injury are vast, and the time is right for challenging in vivo systemic work both at pre-clinical and clinical levels.
Teaching the Art of Caring for Women
Authors: S. Leon Israel
Journal: JAMA (1965)

Thend obstetrics as a single specialty has taken place naturally. Their fusion became inevitable when midwifery matured into obstetrics and when increasing knowledge of physiology as well as of technical minutiae made pelvic surgery more reparative than extirpative. As a separate discipline gynecology-obstetrics applies the science and art of both medicine and surgery to ailments peculiar to women, particularly of those involving the reproductive organs. The early history of gynecology is a record of brilliant surgical achievements; its more recent nonsurgical affiliations have created a problem in graduate education. The issue is heightened because increasing specialization has tended to raise higher the wall between surgical and nonsurgical practices. But the gynecologist-obstetrician must tend both sides of the fence. The instruction imparted to a resident in gynecology-obstetrics is such that he is prepared to perform operative obstetrics as well as such surgical procedures as colpoplasty and pelvic laparotomy. These facets of
Ovarian failure after total body irradiation.
Authors: P M Cumber, J A Whittaker
Journal: BMJ (1990)

SIR,-The report of a stone fish "bite" by Drs T Llewellyn and A Fraser-Moodie' illustrates the result of having been "bitten" by a stone fish and makes recommendations for treatment.The stone fish, genus synancejidae, does not bite
New mutation in scrapie amyloid precursor gene (at codon 178) in Finnish Creutzfeldt-Jakob kindred
Authors: LevG. Goldfarb, Matti Haltia, Paul Brown, Ana Nieto, Jussi Kovanen, W. Richard Mccombie, Susan Trapp, D. Carleton Gajdusek
Journal: The Lancet (1991)