PURPURA AS A MANIFESTATION OF PENICILLIN SENSITIVITY
Authors: Leo H. Criep, Sheldon G. Cohen
Journal: Annals of Internal Medicine (1951)

Article1 May 1951PURPURA AS A MANIFESTATION OF PENICILLIN SENSITIVITYLEO H. CRIEP, M.D., SHELDON G. COHEN, M.D.LEO H. CRIEP, M.D.Search for more papers by this author, SHELDON G. COHEN, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-34-5-1219 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptINTRODUCTIONPurpura as a manifestation of penicillin sensitivity has been reported infrequently. Price1first reported a "punctate purpuric eruption" occurring in a patient receiving intramuscular penicillin, and noted that the eruption appeared for two days preceding the onset of urticaria, arthralgia, fever, and leukocytosis. Hinman, Warner and Li2reported the development of "giant ecchymoses" over the entire body, but most pronounced over the injection sites on the buttocks, in an 85 year old white male, seven days after a scarlatiniform and urticarial penicillin eruption had subsided. Anderson3described "an anaphylactic (intestinal) purpura associated with transient swelling of the joints and...Bibliography1. Price IC: Severe allergic reaction to intramuscular penicillin, Canad. M. A. J. 53: 485-486, 1945. MedlineGoogle Scholar2. HinmanWarnerLi ATGFJG: Delayed reaction following penicillin therapy, California Med. 65: 112-114, 1946. Google Scholar3. Anderson AB: Anaphylactic purpura following intramuscular therapy, M. J. Australia 34: 305-306, 1947. CrossrefGoogle Scholar4. DerzavisBeinstein JLJ: Hemorrhagic gangrenous exfoliative dermatitis following penicillin in oil and beeswax; combined immediate and delayed reactions, M. Ann. District of Columbia 17: 32-33, 1948. MedlineGoogle Scholar5. Brown EA: Reactions to penicillin, a review of the literature 1943-1948, Ann. Allergy 6: 725-746, 1948. Google Scholar6. PeckSiegalGlickKurtin SMSAWA: Clinical problems in penicillin sensitivity, J. A. M. A. 138: 631-640, 1948. CrossrefMedlineGoogle Scholar7. Sturgis CC: Hematology, 1948, Chas. C. Thomas, Springfield, Illinois, p. 419. Google Scholar8. PetersHorton GABT: Allergic purpura with especial reference to hypersensitiveness to cold, Proc. Staff Meet., Mayo Clin. 16: 631, 1941. Google Scholar9. YaterNicklas WMEW: Cold allergy; report of unusual case, Ann. Int. Med. 15: 743, 1941. LinkGoogle Scholar10. Feinberg SM: Allergy in practice, 1946, Year Book Publishers, Inc., Chicago, p. 772. Google Scholar11. Ibid. p. 346. Google Scholar12. Macht DI: Thromboplastic properties of penicillin and streptomycin, Science 105: 313-314, 1947. CrossrefMedlineGoogle Scholar13. MaldoskyHasselbrockCatino LFWJC: Studies in the mechanism of penicillin action. 1. Penicillin effects on blood coagulation, Science 102: 38, 1945. CrossrefMedlineGoogle Scholar14. FlemmingFish AVW: Influence of penicillin on the coagulation time of blood with a special reference to certain dental operations, Brit. M. J. 2: 242-243, 1947. MedlineGoogle Scholar15. Lewis JH: Effect of penicillin on blood coagulation, Proc. Soc. Exper. Biol. and Med. 63: 538, 1946. CrossrefMedlineGoogle Scholar16. Lewitus ZA: Prothrombinopenic effect of penicillin, Arch. Int. Med. 82: 625, 1948. CrossrefGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: *Received for publication May 10, 1949.From the Section on Allergy, Department of Medicine, School of Medicine, University of Pittsburgh, and the Veterans Administration Hospital, Aspinwall, Pennsylvania.Published with permission of the Chief Medical Director, Department of Medicine and Surgery, Veterans Administration, who assumes no responsibility for the opinion or conclusions drawn by the author. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byState-of-the-Art Review: Vascular Thrombohemorrhagic Disorders: Hereditary and AcquiredBIBLIOGRAPHYKrankheiten der GefäßeDer Einfluß von Vitamin P auf die experimentelle Penicillin-IntoxikationCardiovascular allergy due to penicillin, sulfadiazine, and bacterial sensitization 1 May 1951Volume 34, Issue 5Page: 1219-1223KeywordsAllergy and immunologyArthralgiaFeversHospital medicineInflammationLeukocytosisPenicillinSurgeryUrticaria Issue Published: 1 May 1951 PDF downloadLoading ...