tbuckley/cabot-search huggingface dataset:
Abstract 4193: New Left Bundle Branch Block in ST-Elevation Myocardial Infarction Patients Undergoing Primary Percutaneous Coronary Intervention
Authors: Christopher J Solie, David M Larson, Frank Aguirre, Sue Duval, Amanda M Pfeiffer, Anushree Agarwal, Sushma Koneru, Scott W Sharkey, Timothy D Henry
Journal: Circulation (2009)
Cacosmia and neurobehavioral dysfunction associated with occupational exposure to mixtures of organic solvents
Authors: C M Ryan, L A Morrow, M Hodgson
Journal: American Journal of Psychiatry (1988)

This study examined the interrelationships among occupational exposure to mixtures of organic solvents, neurobehavioral functioning, and complaints of cacosmia. The latter was defined as nausea, headaches, and subjective distress in individuals exposed to neutral environmental odors. The authors administered a battery of cognitive tests to men with and without a history of solvent exposure and found exposed workers to be impaired across a wide range of cognitive domains. Multiple regression analyses of exposed workers demonstrated a highly significant relationship between a history of cacosmia and performance decrements on measures of learning and memory.
Abstract 4226: Elevated Levels of Lp(a) Predict Coronary Atherosclerosis as Detected by Coronary Artery Calcium Scanning with Computed Tomography
Authors: Kamran Akram, Manoefris Kasim, Szilard Voros
Journal: Circulation (2008)

INTRODUCTION Lipoprotein (a) [Lp(a)] has been established as an independent cardiac risk factor. There is considerable variation among different races and the association between Lp(a) and coronary artery calcium (CAC) is unknown in Asians. METHODS 104 patients (pts) from Jakarta, Indonesia underwent CAC scoring and measurements of various biomarkers including Lp(a) (DAIICHI Pure Chemicals, Japan). Lp(a) &gt;20mg/dl were defined as abnormal; CAC was expressed as Agatston score. Lp(a) values were not normally distributed and Kruskal-Wallis test and median values were used to test Lp(a) levels across CAC ranges (0, 1–100, 101– 400, &gt;400). ROC curve analysis tested the performance of Lp(a) to predict presence of any CAC. RESULTS 53/104 (51%) pts had an abnormal Lp(a) level. Clinical characteristics were similar between the two groups (60% male, 14% DM, 57% HTN, 30% smoker). Pts with abnormal Lp(a) had higher mean total cholesterol (220±48 vs. 199±147, p=0.01), LDL (147±40 vs. 130±38, p =0.02) and Lp(a) level (10.2±5.2 vs. 40.8±5.2, p=0.001) but similar HDL (46±10 vs. 45±9, p=NS) and triglyceride (154±113 vs. 145±95, p=NS) levels. Lp(a) was a good test in predicting presence of CAC as evidenced by an area under the curve (AUC)=0.7 with the optimal cut-point of &gt;17mg/dl (sensitivity 73%, specificity 73%, p&lt;0.001). Kruskal-Wallis analysis showed median Lp(a) levels to be significantly higher across rising CAC ranges: 0=41.5, 1–100=54.9, 101– 400=62.1, &gt;400=64 mg/dl (p=0.026). After adjusting for the above clinical characteristics and biochemical markers in a multivariate logistic regression model Lp(a) levels remained a significant predictor of CAC (p=0.007). CONCLUSION This is the first study to demonstrate a significant relationship between Lp(a) levels and presence of CAC in an Asian population.
Sexual risk behaviour and its determinants among men who have sex with men in Catalonia, Spain
Authors: C Folch, R Muñoz, K Zaragoza, J Casabona
Journal: Eurosurveillance (2009)

To evaluate the prevalence of sexual risk behaviours among men who have sex with men (MSM) in Catalonia and to identify sociodemographic, psychosocial, and behavioural factors associated with unprotected anal intercourse (UAI) with casual partners a convenience sample of 850 MSM was recruited in 2006. An anonymous questionnaire was used to explore risk behaviours during the previous 12 months. Logistic regression models were used to examine the variables associated with UAI. Mean age was 41 years and 20.4% were immigrants. Among those with casual partners (91.7% of all respondents), 31.4% had UAI. The multivariate analysis revealed that the likelihood of UAI was higher in men who were HIV-positive (OR: 1.77), used more than four drugs before sex (OR: 4.90 for +6), were not from Spain (OR: 2.10 for Latin American; OR: 1.86 for other immigrants), had more than 20 sexual partners (OR: 1.56), met casual sex partners on the Internet (OR:1.45) and presented a high level of internalised homophobia (OR: 2.40). HIV/STI prevention programmes for MSM in Catalonia should incorporate activities that strengthen self-esteem, take into account the impact of internalised homophobia, and adapt to the sociocultural reality of immigrants. Furthermore, these programmes should also address substance abuse and alert HIV-positive men about the risk of HIV re-infection and transmission of other STI.
Pupillary Responses to High-Irradiance Blue Light Correlate with Glaucoma Severity
Authors: Annadata V. Rukmini, Dan Milea, Mani Baskaran, Alicia C. How, Shamira A. Perera, Tin Aung, Joshua J. Gooley
Journal: Ophthalmology (2015)

To evaluate whether a chromatic pupillometry test can be used to detect impaired function of intrinsically photosensitive retinal ganglion cells (ipRGCs) in patients with primary open-angle glaucoma (POAG) and to determine if pupillary responses correlate with optic nerve damage and visual loss.Cross-sectional study.One hundred sixty-one healthy controls recruited from a community polyclinic (55 men; 151 ethnic Chinese) and 40 POAG patients recruited from a glaucoma clinic (22 men; 35 ethnic Chinese) 50 years of age or older.Subjects underwent monocular exposure to narrowband blue light (469 nm) or red light (631 nm) using a modified Ganzfeld dome. Each light stimulus was increased gradually over 2 minutes to activate sequentially the rods, cones, and ipRGCs that mediate the pupillary light reflex. Pupil diameter was recorded using an infrared pupillography system.Pupillary responses to blue light and red light were compared between control subjects and those with POAG by constructing dose-response curves across a wide range of corneal irradiances (7-14 log photons/cm(2) per second). In patients with POAG, pupillary responses were evaluated relative to standard automated perimetry testing (Humphrey Visual Field [HVF]; Carl Zeiss Meditec, Dublin, CA) and scanning laser ophthalmoscopy parameters (Heidelberg Retinal Tomography [HRT]; Heidelberg Engineering, Heidelberg, Germany).The pupillary light reflex was reduced in patients with POAG only at higher irradiance levels, corresponding to the range of activation of ipRGCs. Pupillary responses to high-irradiance blue light associated more strongly with disease severity compared with responses to red light, with a significant linear correlation observed between pupil diameter and HVF mean deviation (r = -0.44; P = 0.005) as well as HRT linear cup-to-disc ratio (r = 0.61; P < 0.001) and several other optic nerve head parameters.In glaucomatous eyes, reduced pupillary responses to high-irradiance blue light were associated with greater visual field loss and optic disc cupping. In POAG, a short chromatic pupillometry test that evaluates the function of ipRGCs can be used to estimate the degree of damage to retinal ganglion cells that mediate image-forming vision. This approach could prove useful in detecting glaucoma.
Impaired Perception of Dyspnea in Patients with Severe Asthma
Authors: JOHANNES C. C. M.in't VEEN, HERMELIJN H. SMITS, ANTONIA J. J. RAVENSBERG, PIETER S. HIEMSTRA, PETER J. STERK, ELISABETH H. BEL
Journal: American Journal of Respiratory and Critical Care Medicine (1998)

Poor dyspnea perception might be a risk factor for developing asthma exacerbations. We investigated whether severe asthmatics with recurrent exacerbations (brittle asthma) have different dyspnea perception and sputum cells compared with equally severe, but stable asthmatics, or patients with mild steroid-naive asthma. Fifteen brittle asthmatics (13 female, median age 28 yr [range, 20 to 47 yr]), 15 matched severe-stable asthmatics (14 female, median age 26 yr [range, 17 to 52 yr]), and 11 mild asthmatics (8 female, median age 25 yr [range, 19 to 43 yr]) underwent inhalation tests with methacholine (MCh), and hypertonic saline combined with sputum induction. Dyspnea was assessed by Borg and Visual Analogue Scale (VAS), plotted against the percent fall in FEV1, and expressed as the slope of the regression line (Slope-Borg and Slope-VAS). The brittle and stable asthmatics had poorer perception than patients with mild asthma (Slope-Borg [p = 0.036], Slope-VAS [p < 0.001] for MCh). In patients with brittle asthma the perception was less as compared with severe-stable asthma (Slope-Borg for MCh: p = 0.05). In the severe asthmatics there was an inverse correlation between sputum eosinophilia and Slope-Borg and Slope-VAS (R = − 0.55, p = 0.002 and R = − 0.37, p = 0.049), whereas this correlation was a positive one in the mild asthmatics (R = 0.79, p = 0.012 and R = 0.67, p = 0.05). In conclusion, patients with severe asthma, particularly those with recurrent exacerbations, have blunted perception of dyspnea, which is related to the degree of sputum eosinophilia. This suggests that increased sputum eosinophilia is an indicator of clinical instabililty, and that eosinophilic airways inflammation might affect dyspnea perception in severe asthma. in 't
Second and third primary tumors in early breast cancer patients
Authors: E. Morgenfeld, F. Tognelli, N. Gercovich, C. García Gerardi, S. Carnaval, E. Gil Deza, E. J. Rivarola, F. G. Gercovich
Journal: Journal of Clinical Oncology (2008)

11518 Background: Multiple cancers have lately called the attention of clinical oncologists involved in breast cancer care. The main reason for the follow-up of a patient with early breast cancer is to prevent complications and/or to detect a second curable primary cancer. The aim of this retrospective study is to describe the clinical features of second and third primary tumors in patients with early breast cancer (EBC) treated and followed at our Institution. Methods: The EBC pts who have developed a second cancer during the last 10 years were included in the present study. Patients with cervix cancer (in situ) and/or skin cancer other than melanoma were excluded. The second cancer was grouped as: “synchronic” when the diagnosis was made within 6 months of the first one and “metachronic” if the time elapsed was superior to it. Third cancers were analyzed as well. Results: Seventy-two pts with EBC presented a second primary cancer. Second cancer: breast (23), ovarian (9), colon (7), melanoma (5), endometrial (4), lung (4), others (20). The “synchronic” (n=12) and “metachronic” (n=60) groups represented 17% and 83% of the total, respectively. Six women (8%) presented a third primary cancer. Third cancer: breast (4), colon (1), myeloma (1). A total of 27 pts (37%) had direct relatives who also presented oncological diseases, 9 of which had been diagnosed with breast cancer. Conclusions: 1) In this cohort of early breast cancer pts, the most frequent second primary cancer was breast, followed by ovarian, colon and melanoma. 2) Most of the second primary cancers were diagnosed symptomatically (64%) and metachronically (83%). 3) Specific screening is the most important tool for diagnosing synchronic or metachronic colon and skin cancers in this population. No significant financial relationships to disclose.
Transforming growth factor beta-1 gene polymorphisms and course of asthma
Authors: Despo Ierodiakonou, Dirkje S. Postma, Gerard H. Koppelman, Jorrit Gerritsen, Wim Timens, H. Marike Boezen, Judith M. Vonk
Journal: European Respiratory Journal (2011)

TGFβ 1  is a cytokine with a potent role in asthma, in particular in airway remodeling. We investigated the role of  TGF  β   1   gene single nucleotide polymorphisms (SNPs) in the course of asthma.  Four haplotype tagging SNPs (rs7254679, rs4803455, rs1800469, rs10417924) were genotyped in 215 asthmatics with a 30-year follow up (population 1) and in 99 asthmatics who provided bronchial biopsies (population 2). Associations of SNPs with lung function, bronchial hyperresponsiveness (BHR i.e. PC 20 ≤16mg/ml), complete remission (pre bronchodilation FEV 1 % predicted ≥ 80% & absence of BHR, symptoms, medication), basement membrane (BM) thickness and number of submucosal vessels were investigated using linear or logistic regression. Associations of SNPs with FEV 1  decline were estimated using mixed effect models, and associations with area covered with smooth muscle and collagen were tested non parametrically.  Population 1: the G-allele of rs7254679 was associated with lower FEV 1  (b (95%CI)=-21.2ml (-40.8;-2.0) and VC (b=-29.8ml (-49.3;-10.4)), increased risk for BHR (OR (95%CI)=2.7 (1.02-6.5)) and less remission (OR=0.3 (0.09-0.99)) The A-allele of rs4803455 was associated with accelerated FEV 1  decline (b=-13.8ml/year (-20.9;-6.7)) and the T-allele of rs1800469 with less FEV 1  decline (b=7.2ml/year (0.8;13.7). Population 2: the G-allele of rs7254679 tended to be associated with increased BM thickness (b=0.7 (-0.1;1.4 p=0.09)).  This is the first study indicating that  TGF  β   1   SNPs play a role in the course of asthma. Further analysis of data of another 40 subjects with bronchial biopsies will allow us to investigate the associations between  TGF  β   1   SNPs and airway remodeling in asthma in more detail.
Association Between Bicuspid Aortic Valve Phenotype and Patterns of Valvular Dysfunction and Bicuspid Aortopathy
Authors: Joon-Won Kang, Hae Geun Song, Dong Hyun Yang, Seunghee Baek, Dae-Hee Kim, Jong-Min Song, Duk-Hyun Kang, Tae-Hwan Lim, Jae-Kwan Song
Journal: JACC. Cardiovascular imaging (2013)
Allergic rhinitis and the common cold – high cost to society
Authors: J. Hellgren, A. Cervin, S. Nordling, A. Bergman, L. O. Cardell
Journal: Allergy (2009)

The common cold and allergic rhinitis constitute a global health problem that affects social life, sleep, school and work performance and is likely to impose a substantial economic burden on society because of absence from work and reduced working capacity. This study assesses the loss of productivity as a result of both allergic rhinitis and the common cold in the Swedish working population.Four thousand questionnaires were sent to a randomized adult population, aged 18-65 years, in Sweden, stratified by gender and area of residence (metropolitan area vs rest of the country). The human capital approach was used to assign monetary value to lost productivity in terms of absenteeism (absence from work), presenteeism (reduced working capacity while at work) and caregiver absenteeism (absence from work to take care of a sick child).Thousand two hundred and thirteen individuals responded, response rate 32%. The mean productivity loss was estimated at 5.1 days or euro 653 per worker and year, yielding a total productivity loss in Sweden of euro 2.7 billion a year. Of the total costs, absenteeism (44%) was the dominant factor, followed by presenteeism (37%) and caregiver absenteeism (19%). Poisson regression analyses revealed that women, people in the 18-29 year age group, and respondents with 'doctor-diagnosed asthma' reported more lost days than the rest of the group.In Sweden, the cost of rhinitis is euro 2.7 billion a year in terms of lost productivity. A reduction in lost productivity of 1 day per individual and year would potentially save euro 528 million.
Clinical and economic impact of urinary tract infections caused by ESBL-producing Escherichia coli requiring hospitalization: A matched cohort study
Authors: E. Esteve-Palau, G. Solande, F. Sánchez, L. Sorlí, M. Montero, R. Güerri, J. Villar, S. Grau, J.P. Horcajada
Journal: Journal of Infection (2015)
Responsibility for Patient Care in Graduate Medical Education
Authors: Katie A. Greenzang, Jennifer C. Kesselheim
Journal: JAMA Pediatrics (2015)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Pediatrics HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Pediatrics journal
Glutathione Peroxidase-1 and Homocysteine for Cardiovascular Risk Prediction
Authors: Renate Schnabel, Karl J. Lackner, Hans J. Rupprecht, Christine Espinola-Klein, Michael Torzewski, Edith Lubos, Christoph Bickel, François Cambien, Laurence Tiret, Thomas Münzel, Stefan Blankenberg
Journal: Journal of the American College of Cardiology (2005)
Familial Resistance to Thyroid Hormone Associated with Decreased Transport Across the Plasma Membrane
Authors: Jacobo Wortsman, Bhartur N. Premachandra, Kelley Williams, Kenneth D. Burman, Ian D. Hay, Paul J. Davis
Journal: Annals of Internal Medicine (1983)

Resistance to thyroid hormone associated with a defect in hormone transport across the plasma membrane occurred in a 74-year-old eumetabolic woman. She had marked elevations in the serum levels of total thyroxine (T4), free T4, and reverse triiodothyronine (rT3). Levels of T3 were only minimally increased. The hyperthyroxinemia was thyrotrophin (TSH) dependent, but was not due to an alteration in the binding of T4 to serum proteins. Refractoriness to thyroxine was only partial, as indicated by the increase in the basal metabolic rate and suppression of the response of TSH to thyrotrophinreleasing hormore (TRH) after the administration of L-thyroxine, 600 µg daily, for 3 weeks. The basic abnormality involved a selective decrease of T4 plasma membrane transport shown by in-vitro studies of erythrocytes. Screening of family members showed similar biochemical abnormalities in two other relatives. In this familial syndrome characterized by eumetabolic hyperthyroxinemia, the alteration of thyroid hormone metabolism seems to involve primarily the partition of T4 between the intra- and extracellular spaces.
Preliminary Report Of The STIM2 Study: A Multicenter Stop Imatinib Trial For Chronic Phase Chronic Myeloid Leukemia De Novo Patients On Imatinib
Authors: Francois-Xavier Mahon, Franck E. Nicolini, Marie-Pierre Noël, Martine Escoffre, Aude Charbonnier, Delphine Rea, Viviane Dubruille, Bruno R. Varet, Laurence Legros, Agnès Guerci, Gabriel Etienne, Francois Guilhot, Stéphanie Dulucq, Philippe Rousselot, Joelle Guilhot
Journal: Blood (2013)
Preoperative (preop) chemosensitivity testing as predictor of treatment benefit in adjuvant stage III colon cancer (CC): Interim analysis of the PEPITA study.
Authors: Alain Hendlisz, Amélie Deleporte, Jean-Luc Van Laethem, Philippe Vergauwe, Marc Van Den Eynde, Guido Deboever, Jos Janssens, Gauthier Demolin, Stephane Holbrechts, Marylene Clausse, Joanna Vermeij, Lionel A. D'Hondt, Stéphanie Laurent, André Efira, Maria Gomez Galdon, Alexis Buggenhout, Marianne Paesmans, Camilo Garcia, Martine J. Piccart-Gebhart, Patrick Flamen
Journal: Journal of Clinical Oncology (2014)

385 Background: Adjuvant chemotherapy (CT) improves stage III CC outcome but is not effective for all patients (pts). PePiTA’s main hypothesis is that absence of metabolic response (MR) of the primary tumor after 1 preop CT course predicts absence of benefit from adjuvant CT (at 3-year DFS). This strategy's aim is to spare pts from useless toxicities, improve healthcare resource allocation, and guide translational research. This interim analysis was performed for safety and feasibility of MR assessment (MRA). Methods: Pts ≥ 18 years, with PS ≤ 1, diagnosed with CC considered for curative resection are eligible, after signed consent. Baseline PET is repeated after 1 CT cycle, followed by surgery. PET quality insurance and MRA are performed centrally and the result is blinded for investigators. Results: From 2010 to 2013, 114 pts—M/F (55%/45%), median age 66 (26-81), ECOG 0/1(92%/8%)—were included in 15 Belgian centers. 11 pts were excluded from analysis: 2 hyperglycemia at baseline PET; 2 withdrew consent; 6 PET-revealed stage IV CC; and 1 second cancer. Preop CT was associated with 5% grade (gr) 3-4 neutropenia, 1% gr 3 diarrhea, 1% gr 3 hypokaliemia, 1% peritonitis and 1% gr 3 thromboembolic events. Colectomies were performed in all pts after a median of 20 days (interquartile interval 18-21): 32 right (31%), 69 left (67%), and 2 procedures not detailed. Pathology showed stages 0 (1%), I (13%), II (34%), III (47%), IV (7%), without lymph node downstaging. Postoperative morbidity is 9% (95%CI 5-16%) and includes fistulas (4%), transient ischemic attack (1%), ileus (2%), and evisceration (1%), but no death. Technical or methodological reasons prevented MRA in 19/103 pts. Median SUVmax was 14.4 (4.9-47.8) at baseline, and 10.9 (0-39.3) on day 14. 2 pts presented with complete MR. For the others, median delta SUVmax was -22% (-60 to +31%). MR was observed in 60% of pts, and was absent in 40%, with equal distribution for stages II and III (p = 1.00). Conclusions: 1 course of CT is feasible before curative surgery for CC, without inducing excessive toxicity, delay or surgical morbidity. MRA indicated metabolic signs of chemoresistance in 40% of the primary tumors. Clinical trial information: NCT00994864.
Abstract 13226: Impact of Esomeprazole on Platelet Reactivity and Clinical Outcome According to CYP2C19 Genotype in Coronary Heart Disease Patients during Dual Antiplatelet Therapy
Authors: Seiji Hokimoto, Koichi Kaikita, Kazuko Nakaawa, Hisao Ogawa
Journal: Circulation (2014)

Background: Several studies have indicated that concomitant use of clopidogrel and a proton pump inhibitor (PPI) is associated with reduced antiplatelet efficacy of clopidogrel, and increased adverse clinical outcomes after stent placement in patients with ACS. The antiplatelet efficacy of clopidogrel depends on CYP2C19 polymorphism or the co-administration of some kind of PPI. The aim of this study was to investigate the effect of CYP2C19 polymorphism and co-therapy with esomeprazole on the antiplatelet efficacy of clopidogrel. Methods: CYP2C19 genotype and the residual platelet reactivity (RPR) were measured in 361 coronary heart disease patients (male, 73.4%; mean age, 69 years), and the risk of cardiovascular events over a 30-day follow-up was assessed to evaluate the impact of co-administration of esomeprazole during dual antiplatelet therapy with aspirin and clopidogrel. Results: The values of RPR did not differ between esomeprazole and non-esomeprazole groups (4389±1112 versus 4079±1355 AU·min, P=0...