ESTROGEN REPLACEMENT THERAPY IN WOMEN WITH CORONARY ATHEROSCLEROSIS
Authors: R W ROBINSON, W D COHEN, N HIGANO
Journal: Annals of Internal Medicine (1958)

Article1 January 1958ESTROGEN REPLACEMENT THERAPY IN WOMEN WITH CORONARY ATHEROSCLEROSISROGER W. ROBINSON, M.D., WILLIAM D. COHEN, Ph.D., NORIO HIGANO, M.D.ROGER W. ROBINSON, M.D., WILLIAM D. COHEN, Ph.D., NORIO HIGANO, M.D.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-48-1-95 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptINTRODUCTIONCoronary heart disease is rarely encountered in premenopausal women.1, 2However, postmenopausally a sharp rise in the incidence of this disease has been reported in the sixth decade of life,3, 4and by the seventh decade the incidence approaches that of men. A fundamental biochemical alteration associated with the menopause is the substantial decrease of ovarian estrogen production, as measured by urinary estrogen levels.5Alterations of the serum lipids coincident with this low estrogen production have been reported. These include increases of serum cholesterol,6, 7of cholesterol-phospholipid ratio,8, 9and of β-/α-lipoprotein-cholesterol ratio.9The frequent association of these abnormalities...Bibliography1. GlendyLevineWhite RESAPD: Coronary disease in youth: comparison of 100 patients under 40 with 300 persons past 80, J. A. M. A. 109: 1775, 1937. CrossrefGoogle Scholar2. GertlerWhite MMPD: Coronary heart disease in young adults. A multidisciplinary study, 1954, Harvard University Press, Cambridge. Google Scholar3. JamesPostSmith TNHWFJ: Myocardial infarction in women, Ann. Int. Med. 43: 153, 1955. LinkGoogle Scholar4. WeinrebGermanRosenberg HLEB: A study of myocardial infarction in women, Ann. Int. Med. 46: 285, 1957. LinkGoogle Scholar5. PincusDorfmanRomanoffRubinBlochCarloFreeman GRILPBLEJH: Steroid metabolism in aging men and women, Recent Progress Hormone Research 11: 307, 1955. Google Scholar6. Dawber TR: Personal communication, 1957. Google Scholar7. 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WuestDryEdwards JHTJJE: The degree of coronary atherosclerosis in bilaterally oophorectomized women, Circulation 7: 801, 1953. CrossrefMedlineGoogle Scholar14. RivinDimitroff AUSP: The incidence and severity of atherosclerosis in estrogen-treated males, and in females with a hypoestrogenic or a hyperestrogenic state, Circulation 9: 533, 1954. CrossrefMedlineGoogle Scholar15. MarmorstonHoffmanSobelStarr JOHP: Urinary estrogen and serum protein-bound iodine levels in a group of post-menopausal women with and without myocardial infarction, Proceedings of Symposium on Arteriosclerosis, Minneapolis, Minnesota, 1955. Google Scholar16. Eilert ML: The effect of estrogens upon the partition of the serum lipids in female patients, Am. Heart J. 38: 472, 1949. Google Scholar17. DeLallaGofman OFJW: Ultracentrifugal analysis of serum lipoproteins, in Methods of biochemical analysis, 1954, Interscience Publishers, New York, p. 459. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: *From the Symposium on the Pathogenesis of Coronary Heart Disease, presented at the Thirty-eighth Annual Session of The American College of Physicians, Boston, Massachusetts, April 10, 1957.From the Medical Division and the Biochemical Research Laboratory, The Memorial Hospital, Worcester, Massachusetts.Supported by Research Grants H-1932 and H-2658, National Heart Institute, the Worcester District Chapter, Massachusetts Heart Association, and the William B. and Isabel H. Smith Fund.Requests for reprints should be addressed to Roger W. Robinson, M.D., Research Laboratory, The Memorial Hospital, 119 Belmont Street, Worcester 5, Massachusetts. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byWhen Practices, Promises, Profits, and Policies Outpace Hard Evidence: The Post-Menopausal Hormone DebateEffect of Long-term Hormone Replacement Therapy on Coronary Endothelial Function in Postmenopausal WomenHormone Replacement Therapy and Cardiovascular DiseasesEffect of estrogen and progesterone on metabolism of apoprotein B in baboonsA Prospective Study of Postmenopausal Estrogen Therapy and Coronary Heart DiseaseExogenous estrogens attenuate dietary hypercholesterolemia and atherosclerosis in the rabbitMyocardial Infarction and Estrogen Therapy in Post-Menopausal WomenSerumlipide im Cyclus der FrauChanges in serum lipids with atromid and chlorophenoxyisobutyric esterIncreased Incidence of Cardiovascular Disease in Castrated WomenApproaches to the Treatment of HypercholesteremiaSTANLEY S. BERGEN JR., M.D., THEODORE B. VAN ITALLIE, M.D., F.A.C.P.Long-term effects of high-dosage estrogen therapy in men with coronary heart diseaseOpposite Sex Hormones in CardiologyMyocardial Infarction—A Ten-year Experience in a Midwestern General HospitalC. T. ANASTASSIADIS, M.D., S. E. SIVERTSON, M.D.Long-term estrogen substitution and atherosclerosisEffects of Long-Term Administration of Estrogens on Serum Lipids of Postmenopausal WomenDie Coronarerkrankungen. Coronarinsuffizienz, Angina pectoris und HerzinfarktEffect of Prolonged Use of Estrogens on Circulating Lipids in Patients with Idiopathic Hyperlipemia or Idiopathic HypercholesteremiaEFFECTS OF SEX STEROIDS ON LIPIDSStudies with ManveneSerum Lipid and Estrogenic Effects of Manvene, a New Estrogen Analog 1 January 1958Volume 48, Issue 1Page: 95-101KeywordsCoronary heart diseaseEstrogensHeartHormonesLipidsMenopausePathogenesisResearch grantsResearch laboratoriesStable coronary artery disease ePublished: 1 December 2008 Issue Published: 1 January 1958 PDF downloadLoading ...