tbuckley/cabot-search huggingface dataset:
Abstract 2688: The expression of lung resistance protein (LRP) in patient ascites predicts platinum resistance in advanced epithelial ovarian carcinoma
Authors: Lacey R. McNally, Peter J. Frederick, Kerri S. Bevis, Jeffrey C. Sellers, Debbie L. Della Manna, J Michael Straughn, Cecil R. Stockard, William E. Grizzle, Donald J. Buchsbaum
Journal: Cancer Research (2010)

Abstract The human lung resistance protein (LRP) is a multidrug resistance protein that has been shown to be overexpressed in numerous chemotherapy resistance models. The precise role of LRP in platinum-resistant epithelial ovarian cancer (EOC) has yet to be fully elucidated. In this study, we sought to determine LRP expression in the tumor cells of ovarian cancer patient ascites of chemotherapy-naïve patients with advanced EOC. After IRB approval was obtained, patient ascites was collected and evaluated for platinum sensitivity, and LRP expression using western blot and immunohistochemistry (IHC). Both patient ascites and primary tumor were treated with 50 uM carboplatin for 48h and cell viability was analyzed. LRP, activated Caspase 3, and tunnel were analyzed using IHC on samples treated with 50uM carboplatin and untreated. A total of 27 patients with advanced-stage EOC undergoing primary cytoreductive surgery at the University of Alabama at Birmingham were consented for the study. Ten patient ascites samples were deemed adequate for analysis. Of these, 3/10 (30%) had increased LRP levels in ascites samples demonstrated by strong IHC staining with capping and confirmed by western blot. These patient samples were platinum resistant as verified by cytotoxicity analysis. Two ascites specimens (20%) lacked LRP expression by IHC and western blot and demonstrated platinum sensitivity on cytotoxicity. Five ascites specimens (50%) displayed intermediate LRP staining and platinum cytotoxicity. Tumor cells in ascites treated with carboplatin had an inverse correlation of LRP staining and activated Caspase 3. There is a strong correlation between LRP expression in the ascites of patients with advanced EOC and platinum resistance in this ex vivo model. This protein may therefore predict poor prognosis disease unlikely to respond to adjuvant platinum therapy. Specifically targeting the LRP in a clinical model may reverse carboplatin resistance. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 101st Annual Meeting of the American Association for Cancer Research; 2010 Apr 17-21; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2010;70(8 Suppl):Abstract nr 2688.
1142-178 The G1675A gene polymorphism of the angiotensin II type 2-receptor gene influences cardiac structural response to antihypertensive therapy
Authors: Markus P Schneider, Arnfried U Klingbell, Karl F Hilgers, Malte Ludwig, Rainer Kolloch, Klaus O Slumpe, Roland E Schmieder
Journal: Journal of the American College of Cardiology (2004)
Intrinsic Cardiac Nerve Activity and Paroxysmal Atrial Tachyarrhythmia in Ambulatory Dogs
Authors: Eue-Keun Choi, Mark J. Shen, Seongwook Han, Daehyeok Kim, Samuel Hwang, Sameh Sayfo, Gianfranco Piccirillo, Kyle Frick, Michael C. Fishbein, Chun Hwang, Shien-Fong Lin, Peng-Sheng Chen
Journal: Circulation (2010)

Background— Little is known about the relationship between intrinsic cardiac nerve activity (ICNA) and spontaneous arrhythmias in ambulatory animals. Methods and Results— We implanted radiotransmitters to record extrinsic cardiac nerve activity (ECNA; including stellate ganglion nerve activity and vagal nerve activity) and ICNA (including superior left ganglionated plexi nerve activity and ligament of Marshall nerve activity) in 6 ambulatory dogs. Intermittent rapid left atrial pacing was performed to induce paroxysmal atrial fibrillation or atrial tachycardia. The vast majority (94%) of ligament of Marshall nerve activity were preceded by or coactivated with ECNA (stellate ganglion nerve activity or vagal nerve activity), whereas 6% of episodes were activated alone without concomitant stellate ganglion nerve activity or vagal nerve activity. Paroxysmal atrial fibrillation and atrial tachycardia were invariably (100%) preceded (&lt;5 seconds) by ICNA. Most paroxysmal atrial tachycardia events (89%) were preceded by ICNA and sympathovagal coactivation, whereas 11% were preceded by ICNA and stellate ganglion nerve activity–only activation. Most paroxysmal atrial fibrillation events were preceded only by ICNA (72%); the remaining 28% were preceded by ECNA and ICNA together. Complex fractionated atrial electrograms were observed during ICNA discharges that preceded the onset of paroxysmal atrial tachycardia and atrial fibrillation. Immunostaining confirmed the presence of both adrenergic and cholinergic nerve at ICNA sites. Conclusions— There is a significant temporal relationship between ECNA and ICNA. However, ICNA can also activate alone. All paroxysmal atrial tachycardia and atrial fibrillation episodes were invariably preceded by ICNA. These findings suggest that ICNA (either alone or in collaboration with ECNA) is an invariable trigger of paroxysmal atrial tachyarrhythmias. ICNA might contaminate local atrial electrograms, resulting in complex fractionated atrial electrogram–like activity.
Biomarker monitoring of a population residing near uranium mining activities.
Authors: W W Au, R G Lane, M S Legator, E B Whorton, G S Wilkinson, G J Gabehart
Journal: Environmental Health Perspectives (1995)

We investigated whether residents residing near uranium mining operations (target population), who are potentially exposed to toxicants from mining waste, have increased genotoxic effects compared with people residing elsewhere (reference population). Population surveys were conducted, and 24 target and 24 reference residents were selected. The selected subjects and controls were matched on age and gender and they were nonsmokers. Blood samples were collected for laboratory studies. The standard cytogenetic assay was used to determine chromosome aberration frequencies, and the challenge assay was used to investigate DNA repair responses. We found that individuals who resided near uranium mining operations had a higher mean frequency of cells with chromosome aberrations and higher deletion frequency but lower dicentric frequency than the reference group, although the difference was not statistically significant. After cells were challenged by exposure to gamma-rays, the target population had a significantly higher frequency of cells with chromosome aberrations and deletion frequency than the reference group. The latter observation is indicative of abnormal DNA repair response in the target population.
Estrogen-Progesterone Therapy for Bleeding Gastrointestinal Telangiectasias in Chronic Renal Failure
Authors: Mark H. Bronner, Marion B. Pate, John T. Cunningham, William H. Marsh
Journal: Annals of Internal Medicine (1986)

Gastrointestinal telangiectasias cause hemorrhage in patients with chronic renal failure. Therapies using vasoconstrictors, endoscopic application of heat, and surgery have had limited efficacy. Because several reports have suggested that estrogen or estrogen-progesterone therapy may control mucosal bleeding from telangiectasias in patients with hereditary hemorrhagic telangiectasia, we treated seven patients with chronic renal failure and bleeding gastrointestinal telangiectasias with systemic estrogen or estrogen-progesterone in an uncontrolled trial. Bleeding ceased in all patients. Blood transfusion requirements decreased from a mean of 1.2 U/month before treatment to 0.21 U/month after treatment. No significant side effects were noted. Results of this trial indicate the need for controlled investigations of this type of hormonal therapy.
A RANDOMIZED CLINICAL TRIAL OF REGIONAL CEREBRAL PERFUSION VERSUS DEEP HYPOTHERMIC CIRCULATORY ARREST: FIVE-YEAR FOLLOW-UP FOR NEURODEVELOPMENTAL OUTCOMES IN CHILDREN WITH FUNCTIONAL SINGLE VENTRICLE
Authors: Melissa Smith-Parrish, Sunkyung Yu, Janet Donohue, Richard Ohye, Edward Bove, Mary Best, Caren Goldberg
Journal: Journal of the American College of Cardiology (2013)
Targeting Liposomal Chemotherapy via Both Tumor Cell–Specific and Tumor Vasculature–Specific Ligands Potentiates Therapeutic Efficacy
Authors: Fabio Pastorino, Chiara Brignole, Daniela Di Paolo, Bice Nico, Annalisa Pezzolo, Danilo Marimpietri, Gabriella Pagnan, Federica Piccardi, Michele Cilli, Renato Longhi, Domenico Ribatti, Angelo Corti, Theresa M. Allen, Mirco Ponzoni
Journal: Cancer Research (2006)

Neuroblastoma, the most common solid tumor of infancy derived from the sympathetic nervous system, continues to present a formidable clinical challenge. Sterically stabilized immunoliposomes (SIL) have been shown to enhance the selective localization of entrapped drugs to solid tumors, with improvements in therapeutic indices. We showed that SIL loaded with doxorubicin (DXR) and targeted to the disialoganglioside receptor GD(2) [aGD(2)-SIL(DXR)] led to a selective inhibition of the metastatic growth of experimental models of human neuroblastoma. By coupling NGR peptides that target the angiogenic endothelial cell marker aminopeptidase N to the surface of DXR-loaded liposomes [NGR-SL(DXR)], we obtained tumor regression, pronounced destruction of the tumor vasculature, and prolonged survival of orthotopic neuroblastoma xenografts. Here, we showed good liposome stability, long circulation times, and enhanced time-dependent tumor accumulation of both the carrier and the drug. Antivascular effects against animal models of lung and ovarian cancer were shown for formulations of NGR-SL(DXR). In the chick embryo chorioallantoic assay, NGR-SL(DXR) substantially reduced the angiogenic potential of various neuroblastoma xenografts, with synergistic inhibition observed for the combination of NGR-SL(DXR) with aGD(2)-SIL(DXR). A significant improvement in antitumor effects was seen in neuroblastoma-bearing animal models when treated with the combined formulations compared with control mice or mice treated with either tumor- or vascular-targeted liposomal formulations, administered separately. The combined treatment resulted in a dramatic inhibition of tumor endothelial cell density. Long-term survivors were obtained only in animals treated with the combined tumor- and vascular-targeted formulations, confirming the pivotal role of combination therapies in treating aggressive metastatic neuroblastoma.
FAMILIAL CONTINUAL SKIN PEELING
Authors: AMAL K. KURBAN, HENRY A. AZAR
Journal: British Journal of Dermatology (1969)

Journal Article FAMILIAL CONTINUAL SKIN PEELING Get access AMAL K. KURBAN, AMAL K. KURBAN From the Division of Dermatology, Department of Internal Medicine, American University of Beirut and American University Hospital, Beirut, Lebanon Requests for reprints should be addressed to Dr. Amal K. Kurban, Division of Dermatology American University Hospital, Beirut, Lebanon. Search for other works by this author on: Oxford Academic Google Scholar HENRY A. AZAR HENRY A. AZAR From the Division of Dermatology, Department of Internal Medicine, American University of Beirut and American University Hospital, Beirut, Lebanon Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 81, Issue 3, 1 March 1969, Pages 191–195, https://doi.org/10.1111/j.1365-2133.1969.tb16005.x Published: 01 March 1969 Article history Accepted: 04 August 1968 Published: 01 March 1969
EXTRA-CARDIAC VASCULAR DISEASE IS ASSOCIATED WITH WORSE FIVE-YEAR CLINICAL OUTCOMES BUT NOT WITH VEIN GRAFT FAILURE AFTER CORONARY ARTERY BYPASS GRAFT SURGERY: INSIGHTS FROM THE PREVENT-IV TRIAL
Authors: Ralf E. Harskamp, John Alexander, Phillip Schulte, Schuyler Jones, Judson Williams, Michael Mack, Eric Peterson, C. Michael Gibson, Robert Califf, Nicholas Kouchoukos, T. Ferguson, Robbert de Winter, Renato Lopes
Journal: Journal of the American College of Cardiology (2013)
Expression of Apolipoprotein A-I in Rabbit Carotid Endothelium Protects Against Atherosclerosis
Authors: Rowan Flynn, Kun Qian, Chongren Tang, Nagadhara Dronadula, Joshua M Buckler, Bo Jiang, Shan Wen, Helén L Dichek, David A Dichek
Journal: Molecular Therapy (2011)

Expression of atheroprotective genes in the blood vessel wall is potentially an effective means of preventing or reversing atherosclerosis. Development of this approach has been hampered by lack of a suitable gene-transfer vector. We used a helper-dependent adenoviral (HDAd) vector to test whether expression of apolipoprotein A-I (apoA-I) in the artery wall could retard the development of atherosclerosis in hyperlipidemic rabbits. Carotid arteries were infused with an HDAd expressing rabbit apoA-I or a "null" HDAd and harvested 2 and 4 weeks later. ApoA-I mRNA and protein were detected only in HDAdApoAI arteries. Lesion size, lipid and macrophage content, and adhesion molecule expression were similar in both groups at 2 weeks. Between 2 and 4 weeks, most of these measures of atherosclerosis increased in HDAdNull arteries, but were stable or decreased in HDAdApoAI arteries (P ≤ 0.04 for all end points in 4-week HDAdApoAI versus HDAdNull arteries). A longer-term study in chow-fed rabbits revealed persistence of HDAd vector DNA and apoA-I expression for ≥48 weeks, with stable vector DNA content and apoA-I expression from 4 to 48 weeks. Expression of apoA-I in arterial endothelium significantly retards atherosclerosis. HDAd provides prolonged, stable expression of a therapeutic transgene in the artery wall.
DETECTION AND TREATMENT WITH EMETINE BISMUTH IODIDE OF AMOEBIC DYSENTERY CARRIERS AMONG CASES OF IRRITABLE HEART
Authors: M. W. Jepps, J. C. Meakins
Journal: BMJ (1917)

1 drop = 1c,, n. t The blood and antiseptic were miixed, inctubated twenty-four hours and then the suspension of staphylococci added.ln these experi-
Response of the human intestine to high volume infusion.
Authors: C Steadman, P Kerlin
Journal: Gut (1994)

The motor patterns and luminal capacity of the human intestine should affect symptoms and resorption during pathological, massive small intestinal flow. Little is known of human intestinal motility in this situation. This study aimed at mimicking secretory diarrhoea (experimentally) in healthy volunteers by intrajejunal infusion of a non-absorbable iso-osmotic solution at 20 ml/min. During the infusion intraluminal jejunal pressures and small intestinal transit times were measured. The infusion initially caused jejunal contractile activity similar to that of the fed state but this was replaced by discrete clusters of contractions (DCCs) after 29.1 ((SEM) 8.2) minutes. DCCs each lasted 38 ((SEM) 0.8 seconds) and were associated with colicky abdominal discomfort. Later, after 1400-1800 ml had been infused, distal jejunal pressure waves fell to 10 mm Hg or less. Frequent fasting DCCs predicted earlier onset and more frequent DCCs during the infusion. Thus, the rate and volume of flow during simulated secretory diarrhoea determine the pattern of the small bowel pressure profile; eventually, a volume load is reached in which the small bowel acts as a poorly segmenting conduit resulting in very fast transit rates.
Heterozygotes for <i>HFE</i> mutations have no increased risk of advanced alcoholic liver disease
Authors: J Grove, A K Daly, A D Burt, M Guzail, O F W James, M F Bassendine, C P Day
Journal: Gut (1998)

Background —Iron overload is common in the livers of alcoholics and may play a role in disease pathogenesis. An MHC like gene, HFE, has recently been identified that is mutated in most patients with hereditary haemochromatosis (C282Y in 90% and H63D in 45% of the remainder). Aim —To examine the hypothesis that these mutations determine hepatic iron status in alcoholics and play a role in predisposition to advanced alcoholic liver disease. Methods —The HFE gene was genotyped in 257 patients with alcoholic liver disease and 117 locally matched healthy volunteers. In addition, iron staining was scored (0–4) on biopsy specimens from fibrotic/cirrhotic patients with and without HFE mutations matched for age and sex. Results —Some 15.7% of fibrotic/cirrhotic patients were C282Y heterozygotes compared with 13.7% of controls (p = 0.77). One control and three patients were C282Y homozygotes. Of chromosomes without the C282Y mutation, 68/442 (15.4%) of patients’ chromosomes carried the H63D mutation compared with 36/216 (16.6%) of control chromosomes (p = 0.91). Significant (&gt;grade 1) hepatocyte iron staining was seen in 6/23 C282Y heterozygotes and 4/26 H63D heterozygotes compared with 4/23 controls. Conclusions —Possession of a single copy of either of the two HFE mutations influences neither liver iron content nor the risk of fibrotic disease in alcoholics.
Response to Letters Regarding Article, “Duration of Cardiopulmonary Resuscitation and Illness Category Impact Survival and Neurologic Outcomes for In-Hospital Pediatric Cardiac Arrests”
Authors: Major Renée I. Matos, R. Scott Watson, Vinay M. Nadkarni, Hsin-Hui Huang, Robert A. Berg, Peter A. Meaney, Christopher L. Carroll, Richard J. Berens, Amy Praestgaard, Lisa Weissfeld, Philip C. Spinella
Journal: Circulation (2013)
A FEW RECENT CASES BEARING UPON THE QUESTION OF OPERATIVE INTERFERENCE IN ABDOMINAL AILMENTS.
Authors: DONALD MACLEAN
Journal: JAMA (1896)

In the following brief paper my main object is of furnish the text for a discussion, by this Section, to one of the most anxious and difficult problems in practical surgery, namely the question of interference or non-interference in cases of abdominal ailment, traumatic or otherwise. A few recent cases in my practice, together with one or two pathologic specimens, which I wish to present for your consideration, will I trust furnish a reasonable excuse for my occupying a few minutes of the time of this important and busy section of theAmerican Medical Association. So much has been said and written about laparotomy for diagnostic and curative puposes in numerous abdominal conditions that further argument on the subject may seem, to some, to be superfluous. But over and above the great crucial question of operative interference it is generally admitted that individual cases of disease or injury possess a
Primary Care for Women-Reply
Authors: Jack W. Pearson
Journal: JAMA (1975)

<h3>In Reply.—</h3> Dr Alper's letter evidences to me two areas of confusion that are common to many of us in the recent and remarkable interest revolving about "the primary physician" and "primary medical care." The first is a matter of definition. In my mind, the<i>primary physician</i>is the doctor that the patient relates to and first contacts with problems that she (or he) perceives as related to ill health. This physician represents her initial contact with health services, assesses her condition, and coordinates her subsequent course whether it requires only primary care, which he can accomplish, or other levels of care by referral to appropriate providers. On the other hand (as implied in the term),<i>primary care</i>represents that level of medical care that any qualified physician should be capable of rendering and that will be adequate for the vast majority of a patient's needs and complaints. As observed
A Randomized Controlled Trial of a Low-Molecular-Weight Heparin (Enoxaparin) to Prevent Deep-Vein Thrombosis in Patients Undergoing Elective Hip Surgery
Authors: Alexander G.G. Turpie, Mark N. Levine, Jack Hirsh, Cedric J. Carter, Richard M. Jay, Peter J. Powers, Maureen Andrew, Russell D. Hull, Michael Gent
Journal: New England Journal of Medicine (1986)

There is experimental evidence that low-molecular-weight fractions of heparin are as effective as the standard form but cause less bleeding. We therefore performed a double-blind, randomized trial comparing PK10169 low-molecular-weight heparin with placebo for the prevention of venous thrombosis in patients undergoing elective hip surgery. Prophylactic treatment with a fixed dose was begun postoperatively and continued for 14 days. Fifty patients in each treatment group underwent surveillance with [125l]fibrinogen leg scanning and impedance plethysmography. In the first 24 patients, venography was performed only if either surveillance test was positive. Because the rate of venous thrombosis detected in those patients was unexpectedly low, venography was requested in the remaining 76 patients, even if the screening tests were negative. In this latter group, venous thrombosis occurred in 4 patients (10.8 percent) given PK10169 heparin and 20 patients (51.3 percent) given placebo (P = 0.0002); the corresponding rates for proximal-vein thrombosis were 5.4 percent and 23.1 percent, respectively (P = 0.029). In the entire group of 100 patients, venous thrombosis occurred in 12 percent of those given PK10169 heparin and 42 percent of those given placebo (P = 0.0007), and the corresponding rates for proximal-vein thrombi were 4 percent and 20 percent, respectively (P = 0.014). The observed hemorrhagic rate was 4 percent in each treatment group. We conclude that prophylaxis with fixed-dose PK10169 heparin is effective and safe for patients undergoing elective hip replacement. (N Engl J Med 1986; 315:925–9.)
Reduction of non-steroidal anti-inflammatory drug induced gastric injury and leucocyte endothelial adhesion by octreotide.
Authors: J M Scheiman, A Tillner, T Pohl, A Oldenburg, S Angermuller, E Gorlach, G Engel, K H Usadel, K Kusterer
Journal: Gut (1997)

Non-steroidal anti-inflammatory drugs (NSAIDs) induce gastric ulcers.To assess whether the somatostatin analogue octreotide prevents NSAID induced mucosal gastrointestinal damage in both animals and humans. The effect of octreotide on neutrophil adhesion to the endothelium was also evaluated.Male Sprague-Dawley rats were pretreated either with saline (0.3 ml subcutaneously) or octreotide (0.001-1 ng/kg subcutaneously). After 30 minutes gastric ulcers were induced by the intragastric application of NSAIDs (20 mg/kg indomethacin, 200 mg/kg aspirin, 200 mg/kg ibuprofen, or 50 mg/kg diclofenac). Four hours later the rats were killed and gastric mucosal lesions were assessed by computed planimetry. To determine whether octreotide could prevent indomethacin induced injury in humans, 20 healthy volunteers were evaluated in a double blind, placebo controlled study.Octreotide prevented NSAID induced gastric mucosal lesions (p < 0.05). The dose response curve was U shaped and the most effective dose was 0.1 ng/kg. Leucocyte adherence in submucosal venules of the stomach was evaluated by in vivo microscopy. Octreotide (0.1 ng/kg subcutaneously) prevented indomethacin (20 mg/kg intragastric) induced leucocyte adherence in gastric submucosal venules (p < 0.05). Healthy human volunteers received 50 mg indomethacin orally thrice a day concomitantly with either an identical placebo or 0.01 microgram, 0.1 microgram, or 1 microgram octreotide subcutaneously thrice a day for three days. Injury was assessed by endoscopy. There was a negative correlation between the octreotide dose and injury score (p < 0.03 for gastric injury, p < 0.001 for duodenal injury).Octreotide protects the stomach from NSAID induced gastric injury, probably via its ability to reduce NSAID induced neutrophilic adhesion to the microvasculature. Octreotide also ameliorated indomethacin induced gastric and duodenal injury in humans.
Mitotic Control of Cancer Stem Cells
Authors: Monica Venere, Tyler E. Miller, Jeremy N. Rich
Journal: Cancer Discovery (2013)

Abstract Summary: Cancer stem cells are self-renewing, tumorigenic cells at the apex of tumor hierarchies, and postulated to be quiescent in many tumor types. This issue of Cancer Discovery highlights a study that links the presentation of kinetochores within mitosis to an essential requirement for BUB1B/BubR1, broadening our understanding of the cell-cycle machinery in cancer stem cells. Cancer Discov; 3(2); 141–4. ©2013 AACR. See related article by Ding et al., p. 198