THE CURVES OF THYROXINE DECAY IN MYXEDEMA AND OF IODINE RESPONSE IN THYROTOXICOSIS: THEIR SIMILARITY AND ITS POSSIBLE SIGNIFICANCE
Authors: J. H. Means, J. Lerman
Journal: Annals of Internal Medicine (1938)

Article1 December 1938THE CURVES OF THYROXINE DECAY IN MYXEDEMA AND OF IODINE RESPONSE IN THYROTOXICOSIS: THEIR SIMILARITY AND ITS POSSIBLE SIGNIFICANCEJ. H. MEANS, M.D., F.A.C.P., J. LERMAN, M.D.J. H. MEANS, M.D., F.A.C.P., J. LERMAN, M.D.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-12-6-811 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptIn 1924 Segall and Means1 published a curve which represented the average of the basal metabolic responses of a series of thyrotoxic patients to subtotal thyroidectomy, without the previous administration of iodine. They called this the detoxication curve. About a year later Starr, Segall and Means2 published a curve similarly obtained and constructed, representing the basal metabolic response of a similar series of thyrotoxic patients to the oral administration of iodine.†The impressive feature of these two curves was that, save for a post-operative hump on the thyroidectomy curve, the two were, in shape and rate of descent, close to...Bibliography1. SEGALLMEANS HNJH: The immediate effect of subtotal thyroidectomy in toxic goiter. Daily basal metabolism and pulse observations, Arch. Surg., 1924, viii, 176. CrossrefGoogle Scholar2. STARRSEGALLMEANS PHNJH: The effect of iodine in exophthalmic goiter, Arch. Int. Med., 1924, xxxiv, 355. CrossrefGoogle Scholar3. MEANS JH: The thyroid and its diseases, 1937, Lippincott, Philadelphia. Google Scholar4. MEANSTHOMPSONTHOMPSON JHWOPK: On the nature of the iodine reaction in exophthalmic goiter: With particular reference to the effect of iodine late in the course of the disease, Trans. Assoc. Am. Phys., 1928, xliii, 146. Google Scholar5. BOOTHBYSANDIFORD WMI: The quantitative estimate of the catalytic power of adrenalin and thyroxin as calorigenic agents and the relative rate of their decay, Jr. Biol. Chem., 1924, xlix, 41. Google Scholar6. BOOTHBYSANDIFORDSANDIFORDSLOSSE WMIKJ: The effect of thyroxin on the respiratory metabolism and nitrogenous metabolism of normal and myxedematous subjects, Trans. Assoc. Am. Phys., 1925, xl, 195. Google Scholar7. BOOTHBYBALDES WMEJ: Activation and decay curves of thyroxin, Proc. Staff Meet. Mayo Clinic, 1926, i, 166. Google Scholar8. BOOTHBYPLUMMER WMWA: Diseases of the thyroid gland, Chapter XV-A, 1937, Oxford Medicine, Oxford University Press. Google Scholar9. RABINOWITCH IM: On the action of thyroxin, Jr. Biol. Chem., 1924-25, lxii, 245. CrossrefGoogle Scholar10. MEANS JH: On the pathogenesis of Graves' disease, Proc. Staff Meet. Mayo Clinic, 1937, xii, 11. Google Scholar11. MEANSLERMAN JHJ: On the similarity of the thyroxine decay curve and iodine response curve in thyrotoxicosis and its possible significance, Trans. Assoc. Am. Phys., 1937, lii, 26. Google Scholar12. SALTERLERMAN WTJ: Genesis of thyroid protein, New England Jr. Med., 1937, ccxvi, 371. CrossrefGoogle Scholar13. LUNDECLOSSPEDERSEN GKOC: Untersuchungen über den Jodstoffwèchsel. III. Untersuchungen über den Blutjodspiegel bei den primären Thyreotoxikosen, Biochem. Ztschr., 1929, ccvi, 261. Google Scholar14. SALTERCRAIG WTFN: Vicarious metabolic response: The oxygen consumption of surviving tissues in plasma from hyperthyroid organisms, Jr. Clin. Invest., 1938, xvii, 502. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: J. H. MEANS, M.D., F.A.C.P.; J. LERMAN, M.D.Affiliations: Boston, Massachusetts*From the Thyroid Clinic of the Massachusetts General Hospital. Presented in abstract to the Association of American Physicians, Atlantic City, May 1937. Received for publication May 16, 1938.†For graphs, please see the original papers, or MEANS, J. H.: The thyroid and its diseases, 1937, Lippincott,3 figure 42.‡See original paper or MEANS, J. H.: The thyroid and its diseases, Lippincott,3 1937, figures 47, 48 and 49. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byThe ThyroidPostoperative thyreotoxische Krisen nach schilddr�senfernen EingriffenKrankheiten der SchilddrüseINDICATIONS AND CONTRAINDICATIONS FOR TREATMENT OF THYROID CANCER WITH RADIOACTIVE IODINE*WILLIAM H. BEIERWALTES, M.D.Jodstoffwechsel, Schilddr�se und HypophysenvorderlappenA clinical comparison of the effectiveness of 6-n-propylthiouracil and 2-thiouracil as antithyrotoxic agentsMorbus BasedowDisorders of the internal gland secretion in children 1 December 1938Volume 12, Issue 6Page: 811-820KeywordsGratitudeHospitalsOral administrationThyroidThyroidectomyThyroxine ePublished: 1 December 2008 Issue Published: 1 December 1938 PDF downloadLoading ...