tbuckley/cabot-search huggingface dataset:
Abstract 17894: Factors Associated with Cardiac Rehabilitation Attendance in Patients with Coronary Heart Disease in Europe: Results from EUROASPIRE III Survey
Authors: Kornelia Kotseva, Dirk De Bacquer, David Wood
Journal: Circulation (2011)

Objective: To describe patient characteristics and lifestyle and risk factor management in coronary patients participating in cardiac rehabilitation programme (CRP) compared to those who do not. Methods: The EUROASPIRE III survey was conducted in 2006-2007 in 76 centres from 22 European countries. Consecutive patients aged ≤ 80 years with the following diagnoses - coronary artery bypass grafting (CABG), percutaneous coronary intervention (PCI), acute myocardial infarction, and acute myocardial ischaemia- were identified from hospital records and interviewed and examined at least 6 months after their coronary event. Results: A total of 13,935 medical records were reviewed and 8,966 patients interviewed (participation rate 73%). Overall, 44.8% of patients were advised to participate in a CRP and 81.4% of these patients attended at least one session; (36.5% of the whole study population). There were wide variations between countries and diagnostic categories, ranging from 0% in Greece to 85.4% in Lithuania, and from 15.9% in the Ischaemia group to 68.1% in the CABG group. Characteristics associated with participation in a CRP included younger age, male sex, higher educational level, CABG as a recruiting index event and a history of previous PCI or angina pectoris. Those who were smokers at the time of their coronary event were less likely to attend a CRP. Patients participated in a CRP had significantly lower prevalence of smoking, better control of total cholesterol and LDL-cholesterol and higher use of beta-blockers, ACE inhibitors/ARBs and lipid-lowering drugs. There was no association between participation in a CRP, the prevalence of obesity and glucose and blood pressure control. Conclusions: Only one third of all coronary patients reported attending a CRP. Although the control of smoking, cholesterol and the use of cardioprotective medication was better in those who attended a CPR many patients had not achieved the lifestyle and risk factor targets. There is an urgent need of comprehensive, multidisciplinary rehabilitation programmes addressing all aspects of the lifestyle, other risk factors and therapeutic management and a health care system which invests in prevention.
Abstract 1532: Rare Genetic Variant in the hH1 cDNA Clone, R1027Q, Dramatically Alters the Cellular Electrophysiological Phenotype Ascribed to the Common Polymorphism, H558R, and a Brugada Syndrome Mutation, R1512W: Implications for Functional Studies
Authors: Bi-Hua Tan, Michael J Ackerman, Jonathan C Makielski
Journal: Circulation (2008)

Background: Previous studies in the SCN5A- encoded Na channel showed that amino acid substitutions at one position affected function of a Na channel containing a pathogenic mutation elsewhere. The first and most commonly used SCN5A cDNA clone (hH1) is the minor alternatively spliced transcript with an extra glutamine at position 1077 (Q1077), and also differs from the Na channel found in nearly all humans by virtue of a rare amino acid substitution (R1027Q). We hypothesized that R1027Q in previous studies using hH1 may have increased expression levels of the Brugada syndrome (BrS)-associated mutation (R1512W) and the common polymorphism (H558R). Methods: We generated mutations in the alternatively-spliced SCN5A transcript containing Q1077 (as in the hH1 clone) as the wild type (WT) channel to generate channels with the following amino acid substitutions in addition to Q1077ins: H558R, H558R/R1027Q, R1512W, and R1027Q/R1512W. These channels were expressed in HEK-293 cells and current densities measured by whole cell voltage clamp. Results: The current density for H558R was reduced dramatically (−7±2 pA/pF) whereas H558R/R1027Q exhibited normal current density (−297±56 pA/pF) comparable to WT (−310±52 pA/pF). The BrS mutation, R1512W-hH1, was characterized originally as having only subtle inactivation defects but normal current density. However, when we expressed R1512W in the patient’s true WT background (i.e. without R1027Q), the current density was attenuated significantly (−79±19 pA/pF) whereas the double mutant (R1027Q/R1512W) which replicated R1512W-hH1 showed nearly normal density (−180±21 pA/pF, −253±35 pA/pF for hH1, n=10–25 cells). Conclusions: R1027Q, the rare genetic variant present in the hH1 cDNA clone, rescues expression of Na current for channels with H558R and the BrS1-associated mutation, R1512W. Using the hH1 clone which contains R1027Q as background (as is the case for nearly all previous studies of SCN5A mutations) may yield erroneous conclusions regarding the functional impact assigned to putative pathogenic mutations. It may be critical to study mutations in either true WT clones or in the patient’s own genetic background. This research has received full or partial funding support from the American Heart Association, AHA Midwest Affiliate (Illinois, Indiana, Iowa, Kansas, Michigan, Minnesota, Missouri, Nebraska, North Dakota, South Dakota &amp; Wisconsin).
Towards the Ideal Technique of Adult Liver-transplantation - Piggyback Implantation With Latero-lateral Cavo-cavoplasty (pblt-cc) and Without Use of Venovenous Bypass (vvb)
Authors: Jp. Lerut, Olga Ciccarelli, Marc De Kock, Pierre-François Laterre, G. Molle, M. Donataccio, Reynaert, Jean-Bernard Otte
Journal: Hepatology (1994)
Factors with impact on the agreement between different readers in the interpretation of dobutamine stress echocardiograms
Authors: R. Hoffmann, D. Poldermans, H. Lethen, P. Fioretti, P. Van Der Meer, H. Tries, R. Ciani, A. Katz, R. Erbel, P. Hanrath, T. H. Marwick
Journal: Journal of the American College of Cardiology (2001)
Long-term outcome in congenitally corrected transposition of the great arteries
Authors: Thomas P Graham, Yvonne D Bernard, Beverly G Mellen, David Celermajer, Helmut Baumgartner, Frank Cetta, Heidi M Connolly, William R Davidson, Mikael Dellborg, Elyse Foster, Welton M Gersony, Ira H Gessner, Roger A Hurwitz, Harald Kaemmerer, John D Kugler, Daniel J Murphy, Jacqueline A Noonan, Cynthia Morris, Joseph K Perloff, Stephen P Sanders, James L Sutherland
Journal: Journal of the American College of Cardiology (2000)
Financial incentives do not pave the road to good experimentation
Authors: Tilmann Betsch, Susanne Haberstroh
Journal: Behavioral and Brain Sciences (2001)

Hertwig and Ortmann suggest paying participants contingent upon performance in order to increase the thoroughness they devote to a decision task. We argue that monetary incentives can yield a number of unintended effects including distortions of the subjective representation of the task and impaired performance. Therefore, we conclude that performance-contingent payment should not be generally employed in judgment and decision research.
Abstract 9540: Time-Course of Cardiac Improvement During Mechanical Unloading Predicts Outcome After Weaning From Ventricular Assist Devices
Authors: Michael Dandel, Yuguo Weng, Henryk Siniawski, Hans B Lehmkuhl, Thorsten Drews, Thomas Krabatsch, Evgenij Potapov, Christoph Knosalla, Roland Hetzer
Journal: Circulation (2011)

Background: Detection of cardiac improvement which allows long-term transplant-free outcome after weaning from ventricular assist devices (VADs) is a major goal. In patients with normalization of left ventricular (LV) diameters during unloading, the pre-explantation “off-pump” LVEF allows the distinction between patients with and without the potential to remain stable after weaning. However, some patients with LVEF &gt; 45% before VAD removal show early recurrence of heart failure (HF). We assessed this aspect and aimed to find out if unstable improvement can already be recognized before VAD removal. Methods: Among 94 patients weaned from VADs since 1995, a homogenous group of 46 patients with non-ischemic chronic cardiomyopathy (CCM) was selected for the evaluation of ECHO data obtained during serial “off-pump” trials before VAD explantation. Results: In the evaluated patients, post-weaning 10-year survival without HF recurrence reached 66.0 ± 7.6%. In patients with LV end-diastolic diameter (LVEDD) ≤ 55mm and LVEF ≥ 45% at the time of VAD removal, pre-explantation stability of LVEF and/or LVEDD (no or less than 10% alteration in comparison to the best of all off-pump values until VAD removal) showed a 94.1% predictive value for cardiac stability during the first 5 post-weaning years. Pre-explantation alterations of LVEF with &gt; 10% of best “off-pump” values or a decrease of &gt; 10% of the LV end-diastolic relative wall thickness (RWT) during the final off-pump trials in patients with pre-explantation LVEF of between 45% and 50% showed predictive values of 87.5% and 83.3%, respectively, for HF recurrence during the first 3 post-weaning years. The stability of LV systolic wall motion peak velocity (Sm) during off-pump trials and between the detection of maximum cardiac improvement and time of VAD removal also appeared predictive for 5 year post-weaning stability. Patients needing &gt; 6 months for LVEF improvement to ≥ 45% showed 79.1% probability for HF recurrence during the first 3 years. Conclusions: The pre-explantation time-course of LVEF, LVEDD, RWT and Sm is predictive for the long-term post-weaning stability of unloading-induced cardiac recovery. Assessment of these parameters during serial off-pump trials can improve weaning decisions in CCM patients.
Abstract 2863: Use of an Endoscopic Laser Balloon for Epicardial Mapping and Ablation in a Swine Model
Authors: Edward P Gerstenfeld, John Michele
Journal: Circulation (2009)

Background: Epicardial (epi) mapping and ablation has numerous challenges, including poor catheter epi contact and the potential to damage epi vasculature and the phrenic nerve. The Cardiofocus end...
Infusion of Cytotoxic T Cells for the Prevention and Treatment of Epstein-Barr Virus–Induced Lymphoma in Allogeneic Transplant Recipients
Authors: Cliona M. Rooney, Colton A. Smith, Catherine Y.C. Ng, Susan K. Loftin, John W. Sixbey, Yanjun Gan, Deo-Kumar Srivastava, Laura C. Bowman, Robert A. Krance, Malcolm K. Brenner, Helen E. Heslop
Journal: Blood (1998)
A variant CD30 protein lacking extracellular and transmembrane domains is induced in HL-60 by tetradecanoylphorbol acetate and is expressed in alveolar macrophages
Authors: R Horie, K Ito, M Tatewaki, M Nagai, S Aizawa, M Higashihara, T Ishida, J Inoue, H Takizawa, T Watanabe
Journal: Blood (1996)
The value of lymphocytosis in bronchoalveolar lavage in the differential diagnosis between idiopathic pulmonary fibrosis and chronic hypersensitivity pneumonitis
Authors: Ana Villar, Ferran Morell, Javier de Gracia, Mario Culebras
Journal: European Respiratory Journal (2011)

Introduction:  Bronchoalveolar lavage (BAL) is a minimally invasive, well-tolerated bronchoscopy procedure which plays an important role in the diagnosis of interstitial lung disease (ILD). We assessed the value of lymphocytosis in BAL fluid for the differential diagnosis.   Material and methods:  Prospective study of all the 318 patients with ILD through 2004-2010. During the diagnostic process, cytological and immuno-histochemistry studies of BAL fluid were performed.   Results:  We studied 318 patients with ILD (57 FPI, 92 NH, 45 Sarcoidosis). BAL was performed in 230 patients (72%), obtaining median lymphocyte percentages of 8%, 20% and 25% in IPF, HP and Sarcoidosis respectively. Lymphocyte counts were >60% in non IPF patients, 5% of HP and in 2% of Sarcoidosis patients; were >30% in non IPF, 18% HP and 29% Sarcoidosis, and >20% in 5% IPF, 32% HP and 33% Sarcoidosis.  In a study focused exclusively on chronic NH occurring with IPF criteria (ATS/ERS criteria) (n=60), three presented lymphocytosis >20% but were ultimately diagnosed with HP. Lymphocytosis >15% was found in 5/11 (45%) IPF and 3+3/11 (55%) of patients with final diagnoses HP. Lymphocytosis between 10-15% was present in 8/14 (57%) IPF and 6/14 (43%) HP. No significant differences were found in the cellular profile between IPF and HP.   Conclusions:  Lymphocytosis >20% is also a characteristic of HP and Sarcoidosis, since is very rarely found in IPF (5% in our series). In chronic HP the absence of lymphocytosis in BAL >20% does not rule out the diagnosis (35% diagnosed with HP in our series).  This abstract is funded in part by Fis 1001577
Anti-thymocyte globulin (ATG) in fludarabine phosphate-based nonmyeloablative stem cell transplantation: A national dose-finding study.
Authors: D. Bron, Augustin Ferrant, P. Zachee, Johan Maertens, Chantal Doyen, L. Noens, K. Theunissen, W. Schroyens, D. Selleslag, H. Demuynck, R. Schots, P. Martiat, A De Meuter, M. Boogaerts
Journal: Blood (2003)
Abstract 15525: CER-001, a Synthetic HDL-Mimetic, Safely Mobilizes Cholesterol in Healthy Dyslipidemic Volunteers
Authors: Constance H Keyserling, Thomas L Hunt, Heather M Klepp, Robert A Scott, Ronald Barbaras, Anna Schwendeman, Narendra Lalwani, Jean-Louis Dasseux
Journal: Circulation (2011)

Background: CER-001 is a synthetic HDL, comprised of recombinant human ApoA-I complexed with phospholipids and designed to mimic the beneficial properties of natural, nascent pre-s HDL. These benef...
Abstract 3030: Differential Regulation of Valvular Interstitial Cell Dysfunction by Extracellular Matrix Components
Authors: Karien J Rodriguez, Kristyn S Masters
Journal: Circulation (2007)

Calcification is the leading cause of bioprosthetic and native aortic valve failure, but relatively little is known regarding the factors that contribute to the progression of valvular calcification. Because extracellular matrix (ECM) disarray is often observed in explanted diseased valves, we have investigated the role of individual ECM components in the in vitro calcification of valvular interstitial cells (VICs). The transformation of VICs to an osteoblast-like phenotype was quantified in VICs cultured on different types of ECM coatings. The results show that the number and size of calcific nodules formed in VIC cultures, as well as the expression of mineralization markers alkaline phosphatase (ALP) and CBFa1, were highly dependent upon the composition of the culture surface. In fact, VICs cultured on certain ECM components, namely collagen (Coll) and fibronectin (FN), were resistant to calcification, even upon treatment with potent mineralization-inducing growth factors, such as transforming growth factor beta1 (TGFb1). Meanwhile, VIC cultures on fibrin (FB), laminin, and heparin not only had a high number of calcified nodules (p&lt;0.001 vs. Coll, FN), but also elevated levels of ALP and CBFa1 (p&lt;0.02), and the number of nodules on these ‘pro-calcific’ coatings significantly increased upon treatment with exogenous TGFb1 (p&lt;0.05). To explain the ECM-dependence of calcification, the endogenous production of a pro-mineralization factor (TGFb1) was assessed in VICs on anti-calcific (Coll) and pro-calcific (FB) substrates. Quantification of TGFb1 mRNA revealed that VICs on Coll surfaces expressed a significantly lower amount of TGFb1 mRNA than VICs on FB (p&lt;0.01). Furthermore, treatment with a neutralizing antibody to TGFb1 decreased TGFb1 mRNA expression by VICs on Coll in comparison to VICs on FB or polystyrene controls (p&lt;0.02). Thus, we have discovered a strong correlation between VIC calcification and ECM composition. Our findings show that the ECM plays an important role in controlling TGFb1 expression and subsequent calcification of VICs, which may significantly impact the design of biomaterials for valve tissue engineering, understanding of valvular disease, and the development of preventative treatments for valve calcification.
Vaccinations against respiratory tract infections at Hajj
Authors: A.S. Alqahtani, H. Rashid, A.E. Heywood
Journal: Clinical Microbiology and Infection (2014)

The transmission of respiratory tract infections (RTIs) is very high among the Hajj congregation in Mecca, Saudi Arabia. Despite recommendations for vaccinations, pilgrims remain at increased risk of RTIs. In this paper we systematically reviewed available studies assessing the uptake and effectiveness of vaccinations against RTIs among Hajj pilgrims and enumerated important demographic factors, if described, associated with vaccine uptake. Of the 42 included studies, 29 reported on the uptake and effectiveness of influenza vaccine among pilgrims, eight studies reported the uptake of other vaccines, notably pneumococcal, diphtheria and bacillus Calmette–Guérin vaccines, and the remaining five studies described both influenza and non-influenza vaccines. The uptake of seasonal influenza vaccine ranged from 0.7% to 100% across the study populations, with coverage highest in the elderly and those with pre-existing co-morbidities. The effectiveness of influenza vaccine was variable across studies but was significantly effective against laboratory-confirmed influenza (risk ratio 0.56; 95% CI 0.41–0.75; p <0.001) in pooled metadata from six studies. Uptake of diphtheria and pneumococcal vaccines was low, and the only study reporting pertussis among Hajj pilgrims found the presence of pre-Hajj immunity to be significantly protective against disease. Despite favourable evidence of effectiveness, our review shows variable uptake of vaccines across a number of studies with few data available on the uptake of non-influenza vaccines. Mixed-method studies are needed to gauge knowledge, attitudes and practices of Hajj pilgrims regarding vaccination, and randomized controlled trials are required to confirm the efficacy of vaccines and improve uptake in this vulnerable travelling population.
Absorption, Plasma Transport, and Cellular Retention of Cobalamin Analogues in the Rabbit
Authors: J. Fred Kolhouse, Robert H. Allen
Journal: Journal of Clinical Investigation (1977)

Analogues of cobalamin (Cbl; vitamin B12) are prevalent in nature as a result of bacterial synthesis, and are of additional interest because of their potential use as antimetabolites and chemotherapeutic agents. We have synthesized 14 Cbl analogues containing 57Co and have compared their gastrointestinal absorption, plasma transport, and cellular retention to that of [58Co]Cbl in rabbits.
31P-nuclear magnetic resonance evidence of abnormal skeletal muscle metabolism in patients with chronic lung disease and congestive heart failure
Authors: H Tada, H Kato, T Misawa, F Sasaki, S Hayashi, H Takahashi, Y Kutsumi, T Ishizaki, T Nakai, S Miyabo
Journal: European Respiratory Journal (1992)

The development of 31P-nuclear magnetic resonance (NMR) has enabled direct and non-invasive measurements of muscle metabolism. Serial measurements of the phosphocreatine/inorganic phosphate (PCr/Pi) ratio, which is closely related to the adenosine triphosphate/adenosine diphosphate (ATP/ADP) ratio and pH during and after forearm exercise were performed in 11 patients with chronic lung disease (CLD), nine patients with chronic heart failure (CHF) and eight control subjects. As compared with control subjects, the PCr/Pi ratio in the patients with CLD or CHF was lower during the recovery period and significantly lower at three and 4 min exercise. The pH values after exercise were lower in patients with CLD or CHF compared to control subjects. The PCr/Pi ratio at 4 min after exercise in the patients with CLD or CHF did not correlate with parameters of cardiac function or arterial and mixed venous oxygen tension. The arterial oxygen content and output in patients with CLD and CHF were significantly lower than that of control subjects. Nutritional parameters were not statistically different among the three groups. These observations suggest that metabolic abnormalities may be present in the skeletal muscles of patients with CLD and CHF that are not due to under-nutrition. These may result from reduced arterial oxygen output and, partially, from physical detraining.
Salvage chemotherapy with vinblastine, ifosfamide, and cisplatin in recurrent seminoma.
Authors: K D Miller, P J Loehrer, R Gonin, L H Einhorn
Journal: Journal of Clinical Oncology (1997)

PURPOSE Salvage therapy for disseminated germ cell tumors of all histologic subtypes with vinblastine, ifosfamide, and cisplatin (VeIP) will cure approximately 25% of patients. The purpose of this study was to evaluate the activity of VeIP in patients with recurrent seminoma. PATIENTS AND METHODS We conducted a retrospective review of 24 patients with recurrent seminoma who were treated at Indiana University with VeIP as second-line chemotherapy. All patients had received cisplatin-containing regimens as primary chemotherapy and seven had also received prior pelvic radiotherapy. All patients received four courses of VeIP. RESULTS The minimum follow-up duration was 2 years (range, 2 to 9.1), with a median follow-up time of 7 years. Twenty of 24 patients (83%) achieved a complete remission (CR) following VeIP alone. One additional patient was rendered disease-free (NED) with the resection of residual carcinoma. Eight patients have relapsed. Four of six patients with extragonadal primary tumors and two of four who failed to achieve CR with initial chemotherapy are continuously NED with VeIP. Overall, 13 of 24 (54%) are long-term survivors with VeIP salvage chemotherapy. CONCLUSION VeIP has significant curative potential in patients with recurrent seminoma and appears to produce a higher CR rate and more long-term survivors than is achieved in patients with nonseminomatous disease.
Expression profiling in hypoxic non-small cell lung cancer explants reveals a four-gene hypoxia signature
Authors: Katharina Leithner, Christoph Wohlkoenig, Elvira Stacher, Jörg Lindenmann, Freyja-Maria Smolle-Jüttner, Helmut H. Popper, Andelko Hrzenjak, Andrea Olschewski, Horst Olschewski
Journal: European Respiratory Journal (2011)

Background: Hypoxia is frequent in solid cancers like lung cancer and contributes to chemotherapy resistance. To identify patients with hypoxic tumors would be of advantage. Direct oxygen measurements are of limited use, thus, feasible hypoxia markers are needed.

Material and Methods: A novel ex-vivo model was established using fragmented non-small cell lung cancer (NSCLC) specimens cultured three days under hypoxia (1% oxygen) or normoxia. cDNA microarrays were perfomed on hypoxic and normoxic fragments derived from ten patients (five adenocarcinomas, five squamous cell carcinomas). Correction for multiple testing was performed using FDR5.

Results: Histomorphology and viability/apoptosis tests confirmed the viability of the fragments. HIF-1α immunostaining and expression of carbonic anhydrase IX mRNA were increased in hypoxia. Microarray analysis revealed 129 regulated genes with at least two-fold expression change in hypoxia compared to normoxia. Hypoxia-induced gene expression was histology-dependent, only four genes were significantly regulated in both subtypes.

![Figure][1] 



Conclusions: Our novel ex-vivo model is suitable to study hypoxic adaptation in lung cancer. Its advantage is the use of real tumor tissue maintained under different oxygen concentrations. cDNA expression profiling revealed a four-gene hypoxia signature that might be useful in therapies aiming to restore tumor perfusion and oxygenation.

 [1]: pending:yes
Abstract 1992: STEMI Receiving Centers Reduce Door to Balloon Times in Los Angeles County
Authors: Franklin D Pratt, Marc Eckstein, Elizabeth M Cooper, Tue Nguyen, William J Koenig, William J French
Journal: Circulation (2007)

INTRODUCTION: Pre-hospital electrocardiograms (Pre-ECG) performed by paramedics and first call responders have the potential to markedly reduce Door to Balloon Times for patients having an ST segme...