THE EFFECT OF SOME STEROIDS (TESTOSTERONE PROPIONATE, DESOXYCORTICOSTERONE ACETATE AND ASCORBIC ACID, AND 21-ACETOXY Δ-5-PREGNENOLONE, ARTISONE ACETATE, WYETH) IN RHEUMATOID ARTHRITIS
Authors: H M MARGOLIS, P S CAPLAN
Journal: Annals of Internal Medicine (1951)

Article1 January 1951THE EFFECT OF SOME STEROIDS (TESTOSTERONE PROPIONATE, DESOXYCORTICOSTERONE ACETATE AND ASCORBIC ACID, AND 21-ACETOXY Δ-5-PREGNENOLONE, ARTISONE ACETATE, WYETH) IN RHEUMATOID ARTHRITISH. M. MARGOLIS, M.D., F.A.C.P., PAUL S. CAPLAN, M.D.H. M. MARGOLIS, M.D., F.A.C.P.Search for more papers by this author, PAUL S. CAPLAN, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-34-1-61 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe striking observations reported by Hench, Kendall, Slocumb and Polley1 of the beneficial effect of daily administration of 17-hydroxy-11-dehydrocorticosterone (compound E, cortisone), and of pituitary adrenocorticotropic hormone (ACTH) in rheumatoid arthritis, have presented the brightest hope for alleviation of the manifestations of this serious disease. However, lack of sufficient knowledge of the long-range metabolic effects of these potent hormones and their present unavailability for general therapeutic use have stimulated an avid search for some related steroid which may duplicate or approach the effectiveness of the agents employed by Hench.Testosterone propionate is a steroid chemically related to cortisone. In large...Bibliography1. HenchKendallSlocumbPolley PSECCHHF: A hormone of the adrenal cortex (17-hydroxy-11-dehydrocorticosterone: compound E) and of pituitary adrenocorticotropic hormone on rheumatoid arthritis. Preliminary report, Proc. Staff Meet., Mayo Clin. 24: 181, 1949. MedlineGoogle Scholar2. AdairMellorsFarrowWoodardEscherUrban FERCJHHQGCJA: The use of estrogens and androgens in advanced mammary cancer, clinical and laboratory study of 105 female patients, J. A. M. A. 140: 1193, 1949. Watson, J. R., and Fetterman, G. H.: Testosterone propionate in the treatment of advanced carcinoma of the breast, Surg., Gynec. and Obst. 88: 702, 1949. CrossrefMedlineGoogle Scholar3. LewinWassen EE: Effect of combined injections of desoxycortone acetate and ascorbic acid on rheumatoid arthritis, Lancet 2: 993, 1949. CrossrefMedlineGoogle Scholar4. IshmaelHellbaumKuhnDuffy WKAJFM: The effects of certain steroid compounds on various manifestations of rheumatoid arthritis. A preliminary report, J. Oklahoma M. A. 42: 10, 1949. Google Scholar5. SelyeSylvesterHallLeblond HOCECP: Hormonal production of arthritis, J. A. M. A. 124: 201-207, 1944. CrossrefGoogle Scholar6. Unpublished data. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Pittsburgh, Pennsylvania*Received for publication June 17, 1950.From the Departments of Medicine, School of Medicine, University of Pittsburgh, St. Margaret Memorial and Montefiore Hospitals, and the John C. Oliver Memorial Research Foundation of St. Margaret Memorial Hospital.Aided by a grant from the Western Pennsylvania Chapter of the Arthritis and Rheumatism Foundation and the John C. Oliver Memorial Research Foundation of St. Margaret Memorial Hospital. 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SMYTH, M.D., F.A.C.P.Rheumatoid arthritis: A review of recent advances in our knowledge concerning pathology, diagnosis, and treatmentPolyarthritis Resulting from the Treatment of Addison's Disease by DesoxycorticostcroneVitamine und Vitaminkrankheiten 1 January 1951Volume 34, Issue 1Page: 61-71KeywordsAdrenocorticotropic hormoneArthritisHormonesHospital medicinePropionatesRheumatoid arthritisSteroidsTestosterone ePublished: 1 December 2008 Issue Published: 1 January 1951 PDF downloadLoading ...