tbuckley/cabot-search huggingface dataset:
Lipoprotein and oxygen transport alterations in passive smoking preadolescent children. The MCV Twin Study.
Authors: W B Moskowitz, M Mosteller, R M Schieken, R Bossano, J K Hewitt, J N Bodurtha, J P Segrest
Journal: Circulation (1990)

We investigated the cardiovascular effects of lifelong passive cigarette smoke exposure in preadolescent children and examined the following questions: 1) Is systemic oxygen transport altered? 2) Are coronary heart disease risk factors adversely affected? We recruited 216 families from the MCV Twin Study; 105 had at least one smoking parent. Serum thiocyanate and cotinine levels were used as measures of smoke exposure in the children and thiocyanate was proportional to the number of parental cigarettes smoked each day (p = 0.0001). Paternal smoking had no effect on these measures. Whole blood 2,3-diphosphoglycerate was higher in smoke-exposed than unexposed children (p less than 0.01) and was related to the thiocyanate level (p less than 0.02). High density lipoprotein (HDL) cholesterol was lower in passive smoking children (p less than 0.05); the HDL2 subfraction was reduced in passive smoking boys, while the HDL3 subfraction was reduced in passive smoking girls. Significant adverse alterations in systemic oxygen transport and lipoprotein profiles are already present in preadolescent children exposed to long-term passive cigarette smoke, primarily from maternal smoke. Children with long-term exposure to passive smoke may be at elevated risk for the development of premature coronary heart disease.
By No Extraordinary Means: The Choice to Forgo Life-Sustaining Food and Water
Authors: Christine K. Cassell
Journal: JAMA (1987)

Nineteen eighty-six was the tenth anniversary of the landmark decision by the New Jersey Supreme Court regarding Karen Ann Quinlan's right to privacy. In this decision, the court decided that the then-22-year-old woman be removed from the mechanical ventilator that was thought to be sustaining her life and be allowed to die naturally. The decision was based on the extremely poor prognosis for any recovery of sapient function and on Karen's verbal remarks to her parents about the meaning of her quality of life. However, she did not die then, nor did she regain sapient life. She went on to live another eight years in a nursing home, curled in a fetal position, being nourished by a tube into her stomach. The part of her brain that controlled her breathing was clearly not as damaged as the physicians thought, and thus she did not require mechanical ventilation to support her
Real Life: My Mum is My Dad
Authors: Petra Boynton
Journal: BMJ (2004)

ITV 1, 1 August at 10 45 pm Rating: ![Graphic][1]</img>![Graphic][2]</img>![Graphic][3]</img> T ransgender issues have suddenly become very popular. Nadia, the favourite to win this year's Big Brother reality television show, is transsexual. Sky television recently broadcast There's Something About Miriam , where men competed to win the affections of Miriam, a pre-op transwoman (male to female transsexual), not realising that she had a penis. And last Saturday the Guardian newspaper ran a four-page investigative piece on the efficacy of gender reassignment surgery, claiming “public acceptance of transsexuals has grown in recent years.” But a presence in the public eye doesn't necessarily equal acceptance, and transsexuals continue to face hostility, harassment, and abuse. The whole premise of There's Something About Miriam was not a celebration of transgendered life. It was designed to elicit horror from the winning contestant discovering that his dream date had a penis. … [1]: /embed/inline-graphic-1.gif [2]: /embed/inline-graphic-2.gif [3]: /embed/inline-graphic-3.gif
Viaticals for Cancer Patients Gain Popularity in U.S.
Authors: K. Nagy
Journal: JNCI Journal of the National Cancer Institute (1995)

Journal Article Viaticals for Cancer Patients Gain Popularity in U.S. Get access Kate Nagy Kate Nagy Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 87, Issue 4, 15 February 1995, Pages 244–245, https://doi.org/10.1093/jnci/87.4.244 Published: 15 February 1995
Pancake Kidney Detected on Renal Scintigraphy
Authors: Rajnish Sharma, N Savita, K L. Chakravarty, Mita Dutta, Anupam Mondal
Journal: Clinical Nuclear Medicine (2006)

Pancake kidney is an extremely rare renal anomaly resulting from abnormal renal ascent and subsequent fusion. The authors describe a patient with pancake kidneys detected on a Tc-99m DTPA scan. The case reported depicts the scintigraphic findings in such a patient having a pancake kidney.
Dialysis for Psoriasis
Authors: Jonathan Halevy
Journal: JAMA (1979)

<h3>To the Editor.—</h3> Buselmeier et al (240:1270, 1978) have described a psoriatic patient who responded to dialytic therapy. They concluded that "the apparent success of dialysis in treatment of intractable psoriasis... may indicate application of this mode of therapy to psoriatic patients who do not have renal failure." Since the publication of their article, there have appeared in the literature additional reports of successful dialytic therapy in psoriatic patients with normal kidney function.<sup>1-4</sup>Impressed by this accumulating evidence of the possible efficacy of this mode of therapy, we undertook to apply it in three of our most refractory cases of psoriasis. These patients were subjected to 24-hour peritoneal dialysis (one-hour exchange), weekly for a total of ten weeks each. After one month of follow-up, we noted the following observations: There was an obvious improvement in all three patients, with 80% clearing of the skin lesions in one patient
Abstract LB-357: Identification of a new inhibitor of the Golgi system, targeting ADP-ribosylation Factor 1 (Arf1) with potential for cancer therapy
Authors: Yoshimi Ohashi, Hiroshi Iijima, Noriyuki Yamaotsu, Kanami Yamazaki, Shigeo Sato, Mutsumi Okamura, Kenji Sugimoto, Shingo Dan, Shuichi Hirono, Takao Yamori
Journal: Cancer Research (2012)

Abstract [Background] ADP-ribosylation factor 1 (Arf1) plays a major role in mediating vesicular transport. Brefeldin A (BFA), a known inhibitor of the Arf1-guanine nucleotide exchange factor (GEF) interaction, is highly cytotoxic. Therefore, interaction of Arf1 with ArfGEF is an attractive target for cancer treatment. However, BFA and its derivatives have not progressed beyond the pre-clinical stage of drug development because of their poor bioavailability. Here, we aimed to identify novel inhibitors of the Arf1-ArfGEF interaction that display potent antitumor activity in vivo but with a chemical structure distinct from that of BFA. [Results] We exploited a panel of 39 cell lines (termed JFCR39) coupled with a drug sensitivity data base and COMPARE algorithm, resulting in the identification of a possible novel Arf1-ArfGEF inhibitor, (2E,4E)-5-((1S,2S,4aR,6R,7S,8S,8aS)-7-hydroxy-2,6,8-trimethyl-1,2,4a,5,6,7,8,8a-octahydronaphthalen-1-yl)-2-methyl-N-(pyridin-3-ylmethyl)penta-2,4-dienamide (AMF-26), which differed structurally from BFA. By using a pulldown assay with GGA3-conjugated beads, we demonstrated that AMF-26 inhibited Arf1 activation. Subsequently, AMF-26 induced Golgi disruption, apoptosis, and cell growth inhibition. AMF-26 did not inhibit the phosphorylation of Akt and Erk. Computer modeling/molecular dynamics (MD) simulation suggested that AMF-26 bound to the contact surface of the Arf1-Sec7 domain where BFA bound. AMF-26 affected membrane traffic, including the cis-Golgi and trans-Golgi networks, and the endosomal systems. Furthermore, using AMF-26 and its derivatives, we demonstrated that there was a significant correlation between cell growth inhibition and Golgi disruption. In addition, orally administratedAMF-26(83mg/kgofbodyweight;5 days) induced complete regression of human breast cancer BSY-1 xenografts in vivo. [Conclusion] AMF-26 is a novel anticancer drug lead that inhibits the Golgi system, targeting Arf1 activation. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 103rd Annual Meeting of the American Association for Cancer Research; 2012 Mar 31-Apr 4; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2012;72(8 Suppl):Abstract nr LB-357. doi:1538-7445.AM2012-LB-357
Risks, Costs, and Benefits of Dietary Modification
Authors: Robert J. Rubin
Journal: Annals of Internal Medicine (1983)

Dialogue Summaries1 May 1983Risks, Costs, and Benefits of Dietary ModificationRobert J. Rubin, M.D.Robert J. Rubin, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-98-5-883_1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe participants in this session (mostly physicians, dieticians, and representatives from the food industry) focussed almost exclusively on the effects of sodium restriction on the hypertensive person. There was nearly unanimous agreement on the risks and costs of reduced salt intake, and discussion of this topic was brief. The asserted dangers, including delay in necessary pharmacotherapy and injury from a clinically significant sodium deficit, were thought to be unlikely consequences of reasonable dietary management.There was disagreement on the benefit of reducing dietary sodium. Most believed that reducing salt consumption alone would lower blood pressure in a substantial number of... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: Robert J. Rubin, M.D.Affiliations: US. Department of Health and Human Services PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 May 1983Volume 98, Issue 5_Part_2Page: 883-883KeywordsBlood pressureDrug therapyFoodSaltsSodium ePublished: 1 December 2008 Issue Published: 1 May 1983 PDF downloadLoading ...
The Symbol of Modern Medicine
Authors: Jamie Newman
Journal: Annals of Internal Medicine (2004)

Letters17 February 2004The Symbol of Modern MedicineJamie Newman, MDJamie Newman, MDFrom Mayo Clinic College of Medicine; Rochester, MN 55902.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-140-4-200402170-00024 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:I read with interest the article by Wilcox and Whitham (1) on the symbol of modern medicine. The question of one snake or two is interesting from a historical standpoint. However, the more important question is which should be the symbol of modern medicine. The answer is simple, after the 50th anniversary of Watson and Crick's great discovery (2): The symbol should be 2 snakes intertwined in a double helix.References1. Wilcox RA, Whitham EM. The symbol of modern medicine: why one snake is more than two. Ann Intern Med. 2003;138:673-7. [PMID: 12693891] LinkGoogle Scholar2. Judson HF. “The greatest surprise for everyone”—notes on the 50th anniversary of the double helix. N Engl J Med. 2003;348:1712-4. [PMID: 12711749] CrossrefMedlineGoogle Scholar Author, Article, and Disclosure InformationAuthors: Jamie Newman, MDAffiliations: From Mayo Clinic College of Medicine; Rochester, MN 55902. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoThe Symbol of Modern Medicine: Why One Snake Is More Than Two* Robert A. Wilcox and Emma M. Whitham The Symbol of Modern Medicine Robert A. Wilcox and Emma M. Whitham The Symbol of Modern Medicine Michael E. Toedt and Dominique M. Gooby Toedt The Symbol of Modern Medicine Neni Prasad The Symbol of Modern Medicine Adrian G. Letz The Symbol of Modern Medicine Drew Hause The Symbol of Modern Medicine Meyer D. Lifschitz The Symbol of Modern Medicine Sarkis J. Chobanian The Symbol of Modern Medicine David P. Steensma The Symbol of Modern Medicine Konstantinos Paparounas Metrics 17 February 2004Volume 140, Issue 4Page: 311 ePublished: 17 February 2004 Issue Published: 17 February 2004 Copyright & PermissionsCopyright © 2004 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
A prospective study of circulating adipokine levels and risk of multiple myeloma
Authors: Jonathan N. Hofmann, Linda M. Liao, Michael N. Pollak, Ye Wang, Ruth M. Pfeiffer, Dalsu Baris, Gabriella Andreotti, Qing Lan, Ola Landgren, Nathaniel Rothman, Mark P. Purdue
Journal: Blood (2012)
Fundholders' prescribing costs: the first five years
Authors: C. M Harris, G. Scrivener
Journal: BMJ (1996)

<h3>Abstract</h3> <b>Objectives</b>: To determine whether the first five waves of English fundholding practices have reduced their prescribing costs relative to non-fundholding practices, and the duration of any reduction achieved. <b>Design</b>: Analysis of item and cost data for all general practices in England in the six years from April 1990 to March 1996. The practices of each of the first five waves were identified at the Prescription Pricing Authority. <b>Setting</b>: All general practices in England. <b>Main outcome measures</b>: Changes and rates of change in net ingredient cost per prescribing unit, and changes in number of items per prescribing unit in fundholding practices, before and after fundholding, relative to continuing non-fundholders. <b>Results</b>: Absolute prescribing costs increased over the six years, by 66% in the continuing non-fundholders and by 56–59% for fundholders. Successive waves of fundholders showed a similar pattern of change: a small relative reduction in the pre-fundholding year, maximum relative reduction in the first year, and a declining relative reduction in the second and third years. After this, their increases in costs were largely similar to those of non-fundholders. The number of items dispensed remained stable over the six years in all groups. <b>Conclusions</b>: The real budgets operated by fundholders were associated with a reduction in costs of about 6% relative to continuing non-fundholders, and this saving seemed to be retained during the study. The relative reduction was small compared with the absolute increase seen in all groups and disappeared after the third year of fundholding. It was brought about by lowering the average cost per item rather than by giving fewer items. <h3>Key messages</h3> We analysed national data for all general practices in England over the six years from April 1990: the absolute cost per prescribing unit increased greatly in all practices, though to a slightly lesser degree in fundholders The relative reduction in costs of fundholders, compared with non- fundholders, began in the pre-fundholding year, reached about 6% altogether in the first three years of fundholding, and then ceased though the saving remained Reduction in costs was achieved by reduction in the average cost per item rather than by decrease in the number of items dispensed In financial terms fundholding has therefore had some success
Quantitative Angiocardiography in Ischemic Heart Disease
Authors: GLEN W. HAMILTON, JOHN A. MURRAY, J. WARD KENNEDY
Journal: Circulation (1972)

Appropriate surgical and medical management of the patient with ischemic heart disease depends upon a thorough assessment of the clinical and pathophysiologic derangements in left ventricular function. This study examined the spectrum of abnormalities in ventricular function found in 66 patients with documented coronary artery lesions. Catheterization and biplane angiocardiography were used to measure end-diastolic and end-systolic volume (EDV, ESV), systolic ejection fraction (SEF), ventricular mass (LVM), end-diastolic pressure (LVEDP), peak systolic and end-diastolic stress (PSS, EDS), and stroke work (SW). The pattern of ventricular contraction was assessed for hypokinesis, akinesis, and dyskinesis and graded according to severity. The SEF, SW, and contractile pattern were sensitive and interrelated indicators of left ventricular contractile dysfunction or fiber shortening. Measurements of ventricular filling or fiber lengthening (EDV, LVEDP, EDS) were related but less sensitive parameters of dysfunction. However, when contractile function was reduced to about one half of normal, there was an associated marked increase in EDV, EDS, and LVEDP. A wide spectrum of derangements was found ranging from virtually normal function in 18 patients with angina alone to severe dysfunction in 18 patients with myocardial infarction, mitral regurgitation, or heart failure. Abnormalities in ventricular function were uniformly associated with myocardial infarction. Angina alone was associated with minimal or no ventricular dysfunction. Most patients with mitral regurgitation and all patients with heart failure had severe ventricular dysfunction manifested by an increase in EDV, LVM, and PSS, a marked decrease in SEF and SW, and a severe abnormality in contractile pattern.
Human Genetics: A Problem-Based Approach
Authors: Joel Charrow
Journal: Annals of Internal Medicine (1997)

Medical Writings15 August 1997Human Genetics: A Problem-Based ApproachJoel Charrow, MDJoel Charrow, MDNorthwestern University Medical School, Chicago, IllinoisSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-127-4-199708150-00023 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail Human Genetics: A Problem-Based ApproachKorf BR. 363 pages, Boston: Blackwell Science; 1996. $39.95. ISBN 0865423539. Order phone 800-759-6102.Field of medicine: Human genetics.Format: Softcover book.Audience: Medical students and any reader familiar with basic principles of biochemistry, metabolism, and nucleic acid metabolism.Purpose: To serve as a companion textbook for a problem-based introductory course on human genetics.Content: This textbook is organized around specific problems and cases. Each chapter begins with a clinical case involving a specific genetic disorder. As each case is progressively disclosed, relevant topics are introduced and discussed, both in the context of the case ... Author, Article, and Disclosure InformationAffiliations: Northwestern University Medical School, Chicago, Illinois PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 15 August 1997Volume 127, Issue 4Page: 335KeywordsCancer geneticsChromosomal diseasesCongenital disordersGenetic diseasesHuman geneticsInborn errors of metabolismMolecular biologyMutationNucleic acidsPopulation genetics ePublished: 15 August 2000 Issue Published: 15 August 1997 Copyright & PermissionsCopyright © 1997 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Rewards of Teaching and Research
Authors: John Lister
Journal: New England Journal of Medicine (1969)

THE recurring economic problems of Britain have had an intensely depressing effect upon the whole nation, and one of the principles that has become generally accepted as a means of stabilizing the economy is the need for everyone to accept some discipline in the matter of income. It is not surprising, however, that the principle is readily acceptable in general but hard to accept in particular. No section of the community is likely to be content to receive what it considers to be an adverse or unfair decision of the Prices and Income Board, to which the majority of pay . . .
An Aseptic Hospital for Yellow Fever.
Authors: John Bartlett
Journal: JAMA (1897)

Chicago, Oct. 4, 1897. <h3>To the Editor:</h3> —During the epidemic of yellow fever in 1878, I suggested the plan of what might be called an aseptic hospital. The suggestion brought forth no fruit. It seems to me that the present is an opportune time to repeat my proposition. It is based on the assumption that the germ of the disease pervades the atmosphere and that, as a necessity, the patient is continually inspiring new quanta of the noxious toxin. The suggestion is to prepare a building for hospital purposes so that it shall be air-tight. Air enters it and leaves it through channels comparable to the ordinary furnace and ventilating pipes. This air has been heated to a degree judged to be sufficient to destroy the yellow fever germ and subsequently cooled to a proper temperature. It is forced into the building by an air blast, and it is withdrawn
From the National Institutes of Health
Authors: James B. Wyngaarden
Journal: JAMA (1988)

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Multi-tiered genomic analysis of head and neck cancer ties TP53 mutation to 3p loss
Authors: Andrew M Gross, Ryan K Orosco, John P Shen, Ann Marie Egloff, Hannah Carter, Matan Hofree, Michel Choueiri, Charles S Coffey, Scott M Lippman, D Neil Hayes, Ezra E Cohen, Jennifer R Grandis, Quyen T Nguyen, Trey Ideker
Journal: Nature Genetics (2014)