tbuckley/cabot-search huggingface dataset:
ATTITUDE OF BRITISH MEDICAL ASSOCIATION ON EXTENSION OF SICKNESS INSURANCE
Authors: G. C. Anderson
Journal: JAMA (1935)

<h3>To the Editor:—</h3> Iagainst the statement which appears at the beginning of the London Letter in the issue of the issue ofThe Journal of the American Medical Associationfor March 30. The sentence to which I refer is as follows:"In 1930, when this party was in power, the British Medic thissociation brought forward a scheme for a state medical service for the whole populationt" Iwish to state emphatically that the British Medical Association has never brought forwa Medica such scheme. It is true that we have advised the extension of the present national health insurance system to include, first, the dependents of all the existing insured persons and others of a like economic statds;and, secondly, the provision of a consultant service and all necessary specialist and auxiliary forms of diagnosis and treatment, for this defined section of t and treat ent, never advocated the inclusion within the ambit of the national health insurance scheme of that
Protein contact dermatitis
Authors: B. Wüthrich
Journal: British Journal of Dermatology (1996)

Journal Article Protein contact dermatitis Get access B. Wüthrich B. Wüthrich Allergy Unit, Department of Dermatology, University Hospital, 8091 Zurich, Switzerland. Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 135, Issue 2, 1 August 1996, Pages 332–333, https://doi.org/10.1111/j.1365-2133.1996.tb01180.x Published: 01 August 1996
[454] TARGETED IDENTIFICATION OF IRON REGULATED GENES IN PATIENTS WITH HEMOCHROMATOSIS AND HEPATITIS C USING A CUSTOM-MADE WHOLE GENOME cDNA MICROARRAY
Authors: S. Hagist, U. Hebling, D. Kieslich, J. Mangin, H. Sultmann, A. Poustka, D. Schuppan, S. Mueller
Journal: Journal of Hepatology (2007)
Short period of administration of diethylstilbestrol in stuttering priapism in sickle cell anemia
Authors: Adama Dodji Gbadoé, Jean Kossi Assimadi, Yvon Akuété SéGbéna
Journal: American Journal of Hematology (2002)

Fig. 1.Clinical course of this patient with AATP.Each arrow denotes a transfusion
Reduced dopamine-beta-hydroxylase activity in Alzheimer's disease
Authors: A. J Cross, T. J Crow, E. K Perry, R. H Perry, G. Blessed, B. E Tomlinson
Journal: BMJ (1981)

The activity of the noradrenergic marker enzyme dopamine-beta-hydroxylase was measured in brains removed postmortem from control patients and patients with Alzheimer's disease. Enzyme activity was decreased in the frontal and temporal cortices and hippocampus in patients with Alzheimer's disease, but was within the normal range in patients with depression, multiinfarct dementia, and terminal coma.The decrease in enzyme activity in Alzheimer's disease may reflect an abnormality of cortical noradrenergic fibres in some patients with the disease.
Two thirds of deaths from asthma are preventable, confidential inquiry finds
Authors: I. Torjesen
Journal: BMJ (2014)

Two in three deaths from asthma could be prevented by better management of the condition including personal asthma plans for patients, timely reviews of asthma care, and the prescription of more appropriate drugs, says the first confidential inquiry into asthma by the Royal College of Physicians.1

The inquiry looked in depth at the circumstances surrounding 195 asthma deaths in the United Kingdom in the 12 months from February 2012. The reviewers identified primary care failings in the routine care of 70% of the deaths studied: in 59% of deaths asthma guidelines were not fully adhered to, and in 47% of deaths avoidable factors were evident in prescribing.

Mark Levy, a general practitioner and the Royal College of Physicians’ clinical lead for the National Review of Asthma Deaths, said, “We identified major avoidable factors in two thirds of those who died, so it is fair to say that at least two thirds of the deaths could have been avoided.”

Kay Boycott, chief executive of Asthma UK, said, “Parents of children with asthma will be especially horrified that the confidential enquiry showed that children …
Environmental factors in the first months of life and the possible relationship to later development of hypersensitivity
Authors: J. Rugtveit
Journal: Allergy (1990)

The results of skin prick test (SPT) with common aeroallergens (in 870 severely asthmatic children, average age at testing 8.1 years) were analysed and compared with the results of a questionnaire about pets and smoking habits in the children's homes during the first 6 months of life. The study indicates a possible correlation between early massive exposure to certain allergens (cat, timothy) and later development of hypersensitivity. No conclusion can be drawn about a possible role of tobacco-smoking.
Book Review Being Digital By Nicholas A. Negroponte. 243 pp. New York, Alfred A. Knopf, 1995. $22.50. 0-679-43919-6 Silicon Snake Oil: Second thoughts on the information highway By Clifford Stoll. 245 pp. New York, Doubleday, 1995. $22. 0-385-41993-7
Authors: Jerome P. Kassirer
Journal: New England Journal of Medicine (1995)
Regulation of β2-adrenergic receptors in keratinocytes: glucocorticoids increase steady-state levels of receptor mRNA in foetal rat keratinizing epidermal cells (FRSK cells)
Authors: H. TAKAHASHI, H. IIZUKA
Journal: British Journal of Dermatology (1991)

Glucocorticoids increase the β-adrenergic adenylate cyclase response of epidermal keratinocytes. Using FRSK cells, a cultured cell line of foetal rat keratinocytes, the regulatory mechanism of the β-adrenergic augmentation effect was investigated. Treatment with dexamethasone (1 × 10−6 M)increased by 1.5-fold the β-adrenergic adenylate cyclase response of FRSK cells. The effect was observed at 6 h incubation and remained for at least 48 h. The prostaglandin E-adenylate cyclase response was also increased 1.5-fold by glucocorticoid treatment. Neither the adenosine-adenylate cyclase response nor cholera toxin- or forskolin-induced cyclic AMP accumulations were altered. Northern blot hybridization showed that levels of the β2-adrenergic receptor mRNA increased within 3 h. while actin-, Gs-α, Gi-2α, Gi-3α mRNA levels were unchanged. Testosterone. 17β-oestradiol. and progesterone had no effect on either the β2-adrenergic adenylate cyclase response or the expression of β2-adrenergic receptor mRNA. The increase in the numbers of the β-adrenergic receptors was visualized by immunofluorescence with an antibody specific for the β2-adrenergic receptor. Our results indicate that glucocorticoids regulate the β2-adrenergic adenylate cyclase response of FRSK cells through the enhanced expression of the receptor.
Universal grammar and mental continuity: Two modern myths
Authors: Derek C. Penn, Keith J. Holyoak, Daniel J. Povinelli
Journal: Behavioral and Brain Sciences (2009)

Abstract In our opinion, the discontinuity between extant human and nonhuman minds is much broader and deeper than most researchers admit. We are happy to report that Evans &amp; Levinson's (E&amp;L's) target article strongly corroborates our unpopular hypothesis, and that the comparative evidence, in turn, bolsters E&amp;L's provocative argument. Both a Universal Grammar and the “mental continuity” between human and nonhuman minds turn out to be modern myths.
The Technique and Practice of Psychoanalysis
Authors: Leon J. Saul
Journal: JAMA (1967)

<b>Psychoanalytic Techniques: A Handbook for the Practicing Psychoanalyst,</b>edited by Benjamin B. Wolman, 596 pp, $15, New York and London: Basic Books, Inc., 1967. Psychotherapeutic techniques depend on the way the therapist understands the personality of each patient and what changes both patient and therapist strive for. The personality makeup of man may be simple in its broad essentials but is certainly complex in its details, and full of surprises. Freud opened up our understanding of it—he did not close it. Certainly no single school has all the answers, although this is the tone of much orthodox psychoanalytic writing as distinct from contributions that are free inquiries using all available knowledge. Dr. Greenson's book is based primarily on the theory of dammed-up libido, correct in itself but not expanded and enriched by the last 40 years of study which have seen such revolutionary progress in every other clinical and scientific
FACT VS. FICTION TOUCHING YELLOW FEVER INOCULATION, WITH A RECORD OF RESULTS WELL AUTHENTICATED.
Authors: J. McF. GASTON
Journal: JAMA (1890)

The discussion of the claims of inoculation with the attenuated virus of yellow fever for the prevention of this disease or the mitigation of the access, should it be developed, resolves itself now into a consideration of facts. No further argument in regard to the principle upon which inoculation is based seems requisite for the proper understanding of the data which have accumulated illustrating its results. The only question likely to be made is respecting the correctness of the statistics and the trustworthiness of the reporter. But observing the rules which ordinarily determine the value of evidence it will be seen that quite a number of witnesses corroborate the statements of the original experiments. If the observations made and recorded by different individuals at different times and different localities, coincide in the points which substantiate the efficacy of yellow fever inoculation, no reasoning as to the theory of propagation, can
Endoscopic Findings and Treatment of a Recurrent Adenocarcinoma with a Submucosal Tumor-Like Appearance in Short-Segment Barrett’s Esophagus
Authors: K. Yagi, Y. Aruga, A. Nakamura, A. Sekine
Journal: Endoscopy (2006)

We report here the case of a 78-year-old man who developed a recurrence of an adenocarcinoma, 15 months after initial endoscopic mucosal resection (EMR) of adenocarcinoma arising from short-segment Barrett’s esophagus. The recurrent adenocarcinoma had the appearance of a submucosal tumor and was found in an area of squamous epithelium. The new lesion was resected by EMR and the patient has had no further recurrences for 32 months. In the initial endoscopic examination, a red area of short-segment Barrett’s esophagus was detected (Figure [1]). The patient underwent examination by magnifying endoscopy and an irregularly round pit and abnormal capillaries were revealed as a cancerous area. The pathological diagnosis was adenocarcinoma. EMR was performed in February 2001. Histological investigation of the proximal edge of the tumor revealed slight submucosal invasion and squamous epithelium covering the carcinoma: the proximal margin of the resected tissue was defined as carcinoma-negative. The diameter of the cancer was 10 mm. Fifteen months after EMR, endoscopic examination revealed a submucosal tumor-like lesion with a nodular appearance in the area of squamous epithelium proximal to the original site of the tumor (Figure [2 a]). Two biopsy specimens taken from this area showed adenocarcinoma covered by squamous epithelium. This lesion was resected by EMR and was found to be a well-differentiated adenocarcinoma, 1.5 mm in diameter, located in the lamina propria and covered with squamous epithelium (Figure [2 b]). Endoscopic examination was repeated after the second EMR and no residual or recurrent lesion has been found at the latest follow-up examination in January 2005, 32 months after the second EMR. Recently, adenocarcinoma arising from Barrett’s esophagus has been treated by EMR [1] [2] [3] [4] [5]. Giovannini et al. [5] reported that out of 21 patients whose tumor resection by EMR was initially classified as complete, two patients later presented with local recurrence and underwent further treament by EMR. Follow-up endoscopic surveillance for tumor recurrence is necessary after initial EMR treament, because EMR has the potential to become a complete therapy in terms of long-term survival of patients with this disease.
Statins (HMG-CoA reductase inhibitors) reduce CD40 expression in human vascular cells
Authors: F Mulhaupt
Journal: Cardiovascular Research (2003)

Objective: HMG-CoA reductase inhibitors (statins) possess anti-inflammatory and immunomodulatory properties that are independent of their lipid-lowering action. As the CD40–CD40L signaling pathway is implicated in the modulation of inflammatory responses between vascular cells, involving adhesion molecules, pro-inflammatory cytokines, chemokines, we sought to investigate the potential role of statins in regulating the expression of CD40. Methods and Results: Using Western blot, flow cytometry and immunohistochemistry analyses, we observed that four different statins reduced IFN-γ-induced CD40 expression in human vascular cells (endothelial cells, smooth muscle cells, macrophages and fibroblasts). This effect was dose-dependent (from 5 μM to 80 nM) and reversed by addition of l-mevalonate. Activation of vascular cells by human recombinant CD40L, as measured by ELISA for IL-6, IL-8 and MCP-1, was strongly reduced when cells were treated with statins. Immunostaining of human carotid atherosclerotic lesions of patients subjected to statin treatment revealed less CD40 expression on a 'per vascular cell' basis compared to control patients. Although many pleiotropic effects of statins are mediated by nitric oxide synthase (NOS)- or peroxisome proliferator-activated receptor (PPAR)-dependent signaling pathways, we observed similar statin-induced reduction of CD40 expression using NOS inhibitors or different PPAR ligands. Conclusion: Statins decrease CD40 expression and CD40-related activation of vascular cells. These effects are partially reversed by the HMG-CoA reductase product l-mevalonate and are mediated by NOS- or PPAR-dependent pathways. Altogether, these findings provide mechanistic insight into the beneficial effects of statins on atherogenesis. They also provide a scientific rationale for the use of statins as immunomodulators after organ transplantation.
TREATMENT OF HAY FEVER.Read in the Section on Laryngology and Otology, at the Forty-fifth Annual Meeting of the American Medical Association, held at San Francisco, June 5-8, 1894.
Authors: A. C. WOLFE
Journal: JAMA (1894)

Bostock, himself a sufferer from hay fever, gave the first detailed account of this disease in 1819. In 1869 Helmholtz held that the symptoms were produced by vibrios existing in the nasal passage. In 1878, Blackley, by carefully conducted experiments, was led to believe that the pollen of grasses and flowers was the exciting cause of hay fever. In 1883, Roe advocated that hyperesthesia is associated with, or occasioned by a diseased condition, either latent or active, of the naso-pharyngeal mucous membrane. Harrison Allen attributed the disease to permanent or temporary obstruction to one or both chambers. McKenzie claimed that the disease is dependent upon some functional derangement of the nerve centers as its predisposing cause. Sajous advanced that the affection was due to an idiosyncrasy on the part of certain individuals to become affected by certain emanations and that hypertrophy of the nasal mucous membrane increased its irritability and
Abstract 4021: Breaking the dogma: AWT1 hypermethylation in myeloid leukemia despite high expression
Authors: Amy Guillaumet, Juan Sandoval, Manel Esteller, Jean-Pierre Issa, Reiner Sibert, David Monk
Journal: Cancer Research (2012)

Abstract Hematological malignancies are the sixth leading cause of cancer related death worldwide. The Wilms tumor 1 (WT1) gene is over-expressed in numerous cancers with respect to normal cells, and has either a tumor suppressor or oncogenic role depending on cellular context. WT1 has been shown to be detectable at low levels only in CD34+/CD38- hematological stem cells but is undetectable after differentiation. WT1 is reported to be an excellent marker for diagnosis and minimal residual disease in acute myeloid leukemia, but the underlying epigenetic alterations are unknown. Using 23 hematological cancer cell lines we confirm the high expression of WT1 and the transcripts derived the from alternative promoter regions (AWT1) in myeloid associated cancer cell lines. To determine if this expression profile is associated with lineage specific DNA methylation changes we performed bisulphite analysis across the loci. Surprisingly we observe hypermethylation of the AWT1 promoter region in despitehigh levels of expression. This hypermethylation is associated with the expected canonical histone modification signature, with high levels of H3K9me3 and low H3K4me3 or H3K9ac. Subsequent bisulphite pyrosequencing of the WT1 and AWT1 promoters in a 356 cytogenetically characterized hematological malignancies revealed that AWT1 was hypermethylated in 63% and WT1 in 8% of primary myeloid cancers at diagnosis, whereas only 26% and 27% where hypermethylated in primary lymphoid cancers. A subset of these patients were treated with decitabine (5-aza-2′-deoxycytidine), a DNA demethylation agent commonly used to treat myeloid leukemia and myeloproliferative disease. The AWT1 methylation state did not change during treatment suggesting that AWT1 methylation state does not correlate with drug response. Our data suggests that combining (A)WT1 expression and AWT1 methylation analyses will be a useful tool for diagnose and confirmation of myeloid-lineage malignancies. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 103rd Annual Meeting of the American Association for Cancer Research; 2012 Mar 31-Apr 4; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2012;72(8 Suppl):Abstract nr 4021. doi:1538-7445.AM2012-4021
Effect of Portacaval Shunt on Hypersplenism.
Authors: H. J. Tumen
Journal: Annals of Internal Medicine (1961)

s1 May 1961Effect of Portacaval Shunt on Hypersplenism.H. J. Tumen, M.D., F.A.C.P., B. H. Sullivan Jr., M.D., F.A.C.P.H. J. Tumen, M.D., F.A.C.P.Search for more papers by this author, B. H. Sullivan Jr., M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-54-5-1050_1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptPatients with cirrhosis may have a variety of hematologic disturbances. Some of these—anemia, neutropenia, and thrombocytopenia—are attributed to hypersplenism. This is secondary to portal hypertension, which may also lead to the formation of esophageal varices. It is important to determine whether the hematologic consequences of hypersplenism decrease following shunt procedures that lower portal pressure, and also to learn whether, when hypersplenism is marked, splenectomy is required in addition to a shunt operation.A study was made of the effect of end-to-side portacaval shunt upon the anemia, neutropenia, and thrombocytopenia of 25 patients with cirrhosis who required portal decompression because of... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 May 1961Volume 54, Issue 5Page: 1050-1050KeywordsAnemiaCirrhosisNeutropeniaPortal hypertensionSplenectomy ePublished: 1 December 2008 Issue Published: 1 May 1961 PDF downloadLoading ...
National Policy and Demonstration Projects
Authors: William A. Steiger
Journal: New England Journal of Medicine (1969)

It seems entirely logical that private philanthropic foundations with their limited (although sometimes extensive) funds would adopt the policy of supporting demonstration projects. Thus, the Commonwealth Fund would support comprehensive medicine teaching programs in five or so medical schools to demonstrate the feasibility and the utility of such programs to the other 80 odd schools. Although it is agreed that all medical students could benefit from this type of education, the Commonwealth Fund would not be expected to support such programs universally. Such demonstrations foster publications, speeches and interchange with numerous visitors that generate similar, usually self-supported, projects in other . . .
Invasive Dental Treatment and Risk for Vascular Events
Authors: Joseph D. Matthews
Journal: Annals of Internal Medicine (2011)

Letters15 March 2011Invasive Dental Treatment and Risk for Vascular EventsJoseph D. Matthews, DDS, MScJoseph D. Matthews, DDS, MScFrom Advanced Education in General Dentistry Residency Program, University of New Mexico School of Medicine, Albuquerque, NM 87131.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-154-6-201103150-00015 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:Minassian and colleagues' study (1) highlighted the difficulty of applying results from retrospective studies of claims data to clinical practice. The most important confounder that was not discussed by the authors is the proximity of tooth extraction to an odontogenic infection or other acute condition that would necessitate invasive dental treatment.Because the analysis was restricted to dental extractions, ascertaining the reason for the extraction in each case would have been important. Extraction is rarely elective and, in fact, is often delayed until an acute condition makes successful alternatives unlikely. One recent study (2) found that dental ...References1. Minassian C, D'Aiuto F, Hingorani AD, Smeeth L. Invasive dental treatment and risk for vascular events: a self-controlled case series. Ann Intern Med. 2010;153:499-506. [PMID: 20956706] LinkGoogle Scholar2. Aida J, Morita M, Akhter R, Aoyama H, Masui M, Ando Y. Relationships between patient characteristics and reasons for tooth extraction in Japan. Community Dent Health. 2009;26:104-9. [PMID: 19626742] MedlineGoogle Scholar Author, Article, and Disclosure InformationAffiliations: From Advanced Education in General Dentistry Residency Program, University of New Mexico School of Medicine, Albuquerque, NM 87131.Disclosures: None disclosed. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoInvasive Dental Treatment and Risk for Vascular Events Caroline Minassian , Francesco D'Aiuto , Aroon D. Hingorani , and Liam Smeeth Invasive Dental Treatment and Risk for Vascular Events Caroline Minassian , Liam Smeeth , Francesco D'Aiuto , and Aroon D. Hingorani Invasive Dental Treatment and Risk for Vascular Events Sok-Ja Janket , Kamal Jethwani , and Jukka H. Meurman Metrics Cited byRisk of Myocardial Infarction and Ischemic Stroke after Dental Treatments 15 March 2011Volume 154, Issue 6Page: 441KeywordsConflicts of interestPeriodontal diseasesRetrospective studiesVascular diseases ePublished: 15 March 2011 Issue Published: 15 March 2011 Copyright & PermissionsCopyright © 2011 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Doctors and Medicine in Early Renaissance Florence
Authors: John Muendel
Journal: JAMA (1986)

Katharine Park's study is essentially a social history of Florentine physicians during the late 14th and 15th centuries. The theory and practice of medicine are by no means ignored, but much more attention is given to the sociological position of physicians who were responding to the crisis caused by the Black Death following 1348. Utilizing an array of archival and published sources, the author shows that the medical practitioners of Florence were not a small, closed group attending only to the rich. On the contrary, they were a diverse body made up of university-educated physicians and surgeons, as well as surgeons and empirics who had no formal training, but learned only through apprenticeships and experience to treat an assortment of diseases in addition to ailments of the teeth, eyes, and bones, boils, and hernias. Highly specialized and therefore exhibiting a general lack of conflict among themselves, they catered to a