tbuckley/cabot-search huggingface dataset:
Cell-autonomous role of TGFβ and IL-2 receptors in CD4+ and CD8+ inducible regulatory T-cell generation during GVHD
Authors: Norifumi Sawamukai, Atsushi Satake, Amanda M. Schmidt, Ian T. Lamborn, Priti Ojha, Yoshiya Tanaka, Taku Kambayashi
Journal: Blood (2012)
TCT-551 Prophylactic Use of Intracoronary Nicardipine in Conjunction with Distal Protection Devices During Vein Graft Intervention: Synergistic Effect of Combining Drugs and Devices
Authors: Michael Gannon, Harnish Chawla, David Fischman, Nicholas Ruggerio, Paul Walinsky, Babu Jasti, David Ogilby, Suzanne Adams, Michael Savage
Journal: Journal of the American College of Cardiology (2012)
Foot-and-mouth disease in man.
Authors: R Armstrong, J Davie, R S Hedger
Journal: BMJ (1967)

Whether the changes of the Achilles tendon reflexogram in thyroid disorders and in diabetes mellitus are related to the adrenaline system requires further investigation. SUMMARYIn five normal subjects the Achilles tendon reflex time was prolonged by intravenous glucose and shortened by intravenous insulin administration.The effect of insulin was abolished when it was given after the application of propranolol.
Ostial location of target lesion and smaller post-treatment minimal luminal diameter are predictors of failure following Sr-90 beta irradiation for instant restenosis
Authors: Francis Q. Almeda, David Y. Chua, Sandeep Nathan, Susie Kim, Peter M. Meyer, Stephen T. Thew, Jeffrey Snell, Gary L. Schaer
Journal: Journal of the American College of Cardiology (2002)
Abstract 5374: Sulforaphane reactivates the expression of Nrf2 through CpGs demethylation in TRAMP C1 cells.
Authors: Chengyue Zhang, Zheng-Yuan Su, Tin Oo Khor, Ah-Ng Kong
Journal: Cancer Research (2013)

Abstract Prostate cancer is one of the most deadly malignancies among men in the United States. Recent evidence suggests epigenetic alteration is involved during the development and progression of prostate cancer. Previously we have demonstrated that Nrf2, a key regulator of cellular antioxidant defense systems, was epigenetically silenced in TRAMP prostate cancers, as well as tumorigenic TRAMP C1 cells. Sulforaphane (SFN), an isothiocyanate rich in cruciferous vegetables, has been shown to be a potent cancer prevention agent for years. The aim of this study is to investigate the potential of SFN to reactivate the expression of Nrf2 in TRAMP C1 cells via epigenetic modifications. Bisulfite genomic sequencing (BGS) showed that treatment of SFN resulted in demethylation of the first 5 CpGs in the promoter region of Nrf2 gene. Methylation DNA immunoprecipitation (MeDIP) analysis revealed that SFN significantly reduced the anti-mecyt antibody binding to the first 5 CpGs of the Nrf2 promoter, corresponding to the BGS results. Reversion of the methylation status was found to be associated with re-expression of Nrf2 and its downstream NQO-1 at the mRNA and protein levels. Further analysis showed that SFN treatment decreased the expression of DNA methyltransferases (DNMTs), particularly DNMT1 and DNMT3a. Though SFN treatment showed differential effects on the protein expression of various HDACs, it increased the global level of active chromatin marker acetyl-H3. Taken together, our study suggests that SFN may exert its chemoprevention effect through epigenetic regulation modification of Nrf2 gene with subsequent induction of its downstream anti-oxidative stress pathway. Citation Format: Chengyue Zhang, Zheng-Yuan Su, Tin Oo Khor, Ah-Ng Kong. Sulforaphane reactivates the expression of Nrf2 through CpGs demethylation in TRAMP C1 cells. [abstract]. In: Proceedings of the 104th Annual Meeting of the American Association for Cancer Research; 2013 Apr 6-10; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2013;73(8 Suppl):Abstract nr 5374. doi:10.1158/1538-7445.AM2013-5374
Belgian parents are sentenced to prison for not vaccinating children
Authors: Ned Stafford
Journal: BMJ (2008)

Two sets of parents in Belgium who refused to have their children vaccinated against polio, which is compulsory under Belgian law, were convicted earlier this month. Each parent was fined €5500 (£4100; $8000) and sentenced to five months in prison.

In an interview with the BMJ the presiding judge, Bart Meganck of the Court of First Instance in the Flemish city of Dendermonde, said that the parents failed to appear for the 4 February court date. He therefore convicted them on the basis of police reports. He suspended the prison sentences pending whether or not …
A CASE OF LUPUS DISSEMINATUS (POST-EXANTHEMATIC MILIARY TUBERCULOSIS CUTIS).
Authors: HALFDAN SUNDT
Journal: British Journal of Dermatology (1925)

Journal Article A CASE OF LUPUS DISSEMINATUS (POST‐EXANTHEMATIC MILIARY TUBERCULOSIS CUTIS). Get access HALFDAN SUNDT, M.D. HALFDAN SUNDT, M.D. Kysthospital, Fredriksvern, Norway Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology and Syphilis, Volume 37, Issue 7, 1 July 1925, Pages 316–324, https://doi.org/10.1111/j.1365-2133.1925.tb10005.x Published: 01 July 1925
Mast Cell Counts
Authors: RICHARD G. PATTON
Journal: Annals of Internal Medicine (1979)

Letters and Correction1 January 1979Mast Cell CountsRICHARD G. PATTON, M.D.RICHARD G. PATTON, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-90-1-131_1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: I have read with interest the paper by Yoo, Lessin, and Jensen (Ann Intern Med88:753-757, 1978) that reports an attempt to quantitate the degree of bone marrow mast cell proliferation in various hematologic disorders. This was accomplished by a semiquantitative counting technique using a calibrated optical micrometre to examine bone marrow aspiration smears. Although this method appears to be reproducible for bone marrow aspiration smears, I question its validity for quantitation of bone marrow mast cell proliferation. It has been previously reported (1) in a subjective evaluation that bone marrow clot sections are far superior to...Reference1. JOHNSTONE J: The appearance and significance of tissue mast cells in human bone marrow. J Clin Pathol 7:275-279, 1954 CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: RICHARD G. PATTON, M.D. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byBasophils in peripheral blood and bone marrow 1 January 1979Volume 90, Issue 1Page: 131-131KeywordsBone marrowCell proliferationMast cells ePublished: 1 December 2008 Issue Published: 1 January 1979 PDF downloadLoading ...
High‐dose chemoradiotherapy with syngeneic bone marrow transplantation for multiple myeloma: A case report and literature review
Authors: Steven N. Wolff, Thomas L. McCurley, Leonard Giannone
Journal: American Journal of Hematology (1987)

Abstract We had the opportunity to treat a patient with progressive heavily pretreated multiple myeloma with high‐dose chemoradiotherapy with hematopoietic rescue by syngeneic bone marrow transplantation. The patient was a 53‐year‐old male who had previously received melphalan, prednisone, 1,3‐bis (2‐chloroethyl)‐l‐nitrosourea (BCNU), vincristine, and standard radiation therapy. At the time of bone marrow transplantation, he had increasing bone pain, increasing M‐protein (IgG kappa), and a bone marrow diagnostic of myeloma. The transplant regimen consisted of cyclophosphamide, 60 mg/kg intravenously for 2 days, and total body irradiation—1,200 rads given as 200‐rad fractions, twice daily for three days. The transplant course was complicated by confusion, herpes simplex mucositis, fever, and two episodes of idiopathic diffuse interstitial pneumonia. Over the next 2 years the patient did well and was in immunologic and bone marrow complete remission. Unfortunately, 3 years after treatment, the myeloma relapsed with detectable M‐protein. Three and one‐half years after transplant, clinical relapse occurred with bone pain and lytic lesions necessitating additional radiation and chemotherapy. Salvage therapy has produced clinical improvement and the patient is alive almost 4 years from transplant and almost 7 years from diagnosis. Although intense chemoradiotherapy did not cure this patient, substantial control of a refractory tumor was observed. This case, together with other cases of intense therapy for myeloma which are reviewed in this paper, support the concept of high‐dose therapy and should foster further investigation of high‐dose therapy.
Comparing the microbiota of the cystic fibrosis lung and human gut
Authors: Geraint B. Rogers, Mary Carroll, Lukas Hoffman, Alan Walker, David Fine, Kenneth Bruce
Journal: Gut Microbes (2010)

In recent articles (Rogers et al., 2009, Rogers et al., 2010), we discussed a fundamental shift in the way in which polymicrobial infections can be viewed. In these articles, we used chronic bacterial infections of the lower airways, and specifically those that occur in cystic fibrosis (CF) patients, as a model system. These infections are of course critical in clinical terms for these patients; respiratory failure due to a combination of these chronic infections with the host immune response that they elicit remains the leading cause of mortality in CF. Given the importance of maintaining lung health in these patients, the CF airways are the focus of a wide range of scientific and clinical studies. In particular, research momentum has built in relation to identifying the microbes present in the CF lung. Already, many important insights have been gained through the application of increasingly sophisticated culture-independent analytical methodologies to identify all microbial nucleic acids (Bittar et al., 2008, Ecker et al., 2008, Rogers et al., 2004, Sibley et al., 2008b) and those from viable or metabolically active microbes (Rogers et al., 2005, Rogers et al., 2008) in the CF lung. In doing so, the data generated have revealed microbial assemblages of far greater diversity and in turn complexity than has previously been recognised in this context. These studies, which have served to highlight the inadequacy of traditional culture-based diagnostic microbiology to fully characterise such infections (Rogers et al., 2009), have also led to a significant shift in our view of what the word "infection" represents for these and other chronic diseases, with potentially important implications for their optimal treatment. In this article we contrast the information we and others have accrued from chronic lung infections with data generated from studies examining the microbial communities present in the gut. In doing so we highlight parallels between these two contexts and discuss how these commonalities can inform clinical thinking.
Teenagers want schools to give them more information about sex
Authors: J. Wise
Journal: BMJ (2015)

More young people in Britain than ever are getting their information about sex from school, two papers published in BMJ Open have found. However, most people—men in particular—thought that they were not getting all the information they needed.

The research, funded by the Medical Research Council and the Wellcome Trust, showed that men and women who learned about sexual matters at school experienced first sexual intercourse at a later age than those who got their information from other sources such as …
Postgraduate Medical Education — What Is a Consultant? — Beatlemania
Authors: John Lister
Journal: New England Journal of Medicine (1964)

THE upgrading of the peripheral hospitals has been one of the most significant achievements of the National Health Service, and these hospitals are now staffed by specialists and consultants who have undergone a period of training just as long and vigorous as that undertaken by their colleagues working in the teaching hospitals.Furthermore, the wealth and variety of clinical material available in the periphery is often greater than that in the teaching centers, where the development of special units has tended to lead to a high degree of selection of patients. Many teaching hospitals have therefore established associations with regional . . .
Proliferating tricholemmal tumour with lymph node metastases
Authors: M. ARICÓ, E.LA ROCCA, G. NOTO, G. PRAVATÁ, V. RODOLICO
Journal: British Journal of Dermatology (1989)

Journal Article Proliferating tricholemmal tumour with lymph node metastases Get access M. ARICÓ, M. ARICÓ Experimental Dermatology Unit, University of Palermo, Policlinico Giaccone, Palermo, Italy Mario Aricó, Sezione di Dermatologia Sperimentale, Universitá di Palermo, via del Vespro 129, 1‐90127 Palermo, Italy. Search for other works by this author on: Oxford Academic Google Scholar E.LA ROCCA, E.LA ROCCA Experimental Dermatology Unit, University of Palermo, Policlinico Giaccone, Palermo, Italy Search for other works by this author on: Oxford Academic Google Scholar G. NOTO, G. NOTO Experimental Dermatology Unit, University of Palermo, Policlinico Giaccone, Palermo, Italy Search for other works by this author on: Oxford Academic Google Scholar G. PRAVATÁ, G. PRAVATÁ Experimental Dermatology Unit, University of Palermo, Policlinico Giaccone, Palermo, Italy Search for other works by this author on: Oxford Academic Google Scholar V. RODOLICO V. RODOLICO Department of Pathology, University of Palermo, Policlinico Giaccone, Palermo, Italy Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 121, Issue 6, 1 December 1989, Pages 793–797, https://doi.org/10.1111/j.1365-2133.1989.tb08224.x Published: 01 December 1989
Small G-protein Rnd3/RhoE is expressed in brain cancer and affects glioma morphology, motility and invasion
Authors: Abdelhamid Liacini, Donna Sanger, Peter Forsyth
Journal: Journal for ImmunoTherapy of Cancer (2014)

Meeting abstracts Malignant astrocytomas are highly invasive neoplasms infiltrating diffusely into regions of normal brain. Migration or invasion of tumor cells into normal tissue is a principal cause of mortality and is thought to be a multi-factorial process, consisting of cell interaction with
A MCP1 fusokine with CCR2-specific tumoricidal activity
Authors: Moutih Rafei, Jiusheng Deng, Marie-Noëlle Boivin, Patrick Williams, Shannon M Matulis, Shala Yuan, Elena Birman, Kathy Forner, Liangping Yuan, Craig Castellino, Lawrence H Boise, Tobey J MacDonald, Jacques Galipeau
Journal: Molecular Cancer (2011)

Abstract Background The CCL2 chemokine is involved in promoting cancer angiogenesis, proliferation and metastasis by malignancies that express CCR2 receptor. Thus the CCL2/CCR2 axis is an attractive molecular target for anticancer drug development. Methods We have generated a novel fusion protein using GMCSF and an N-terminal truncated version of MCP1/CCL2 (6-76) [hereafter GMME1] and investigated its utility as a CCR2-specific tumoricidal agent. Results We found that distinct to full length CCL2 or its N-truncated derivative (CCL2 5-76), GMME1 bound to CCR2 on mouse lymphoma EG7, human multiple myeloma cell line U266, or murine and human medulloblastoma cell lines, and led to their death by apoptosis. We demonstrated that GMME1 specifically blocked CCR2-associated STAT3 phosphorylation and up-regulated pro-apoptotic BAX. Furthermore, GMME1 significantly inhibited EG7 tumor growth in C57BL/6 mice, and induced apoptosis of primary myeloma cells from patients. Conclusion Our data demonstrate that GMME1 is a fusokine with a potent, CCR2 receptor-mediated pro-apoptotic effect on tumor cells and could be exploited as a novel biological therapy for CCR2 + malignancies including lymphoid and central nervous system malignancies.
Effects of levamisole on normal and abnormal leukocyte locomotion.
Authors: D G Wright, C H Kirkpatrick, J I Gallin
Journal: Journal of Clinical Investigation (1977)

The anti-helminthic drug levamisole hydrochloride has been reported to stimulate immune responses in humans and experimental animals. We have investigated levamisole effects on human leukocyte locomotion in vitro in studies of neutrophils and mononuclear cells from normal adults, from patients with Chediak-Higashi disease and from patients with the syndrome of hyperimmunoglobulin E, recurrent pyogenic infections, and defective leukocyte chemotaxis. Directed migration (chemotaxis) of neutrophils and mononuclear cells from normal adults and from the hyperimmunoglobulin E syndrome patients, but not from Chediak-Higashi patients, were stimulated by levamisole at concentrations of 0.01-1.0 micronM, with stimulation observed most consistently at 0.1 micronM. These concentrations of drug also increased cyclic GMP levels in mononuclear cells and enhanced hexose monophosphate shunt activity in neutrophils, but did not alter chemotactic factor-induced changes in the surface charge of neutrophils. Other concentrations of levamisole did not affect leukocyte locomotion except for a high concentration (5.0 mM) which stimulated both random and directed leukocyte migration. When patients with the hyperimmunoglobulin E syndrome took levamisole by mouth, the abnormal chemotactic responses of their neutrophils were significantly improved towards normal. These studies are the first to show pharmacologic improvement of in vitro leukocyte locomotion in patients in whom recurrent infections have been attributed to a defect of this leukocyte function.
Transformation of refractory anemia with excess of blasts into acute myelogenous leukemia with Ph‐negative chronic myelogenous leukemia‐like characteristics
Authors: Kunihiko Yamauchi, Shigeru Arimori, Tadami Nagao
Journal: American Journal of Hematology (1990)

Abstract We report a 56 year old patient with acute myelogenous leukemia (FAB classification: M2), in whom the number of mature myeloid cells similar to those seen in Ph‐negative chronic myelogenous leukemia increased markedly 2 months after the diagnosis of refractory anemia with excess of blasts (RAEB). This is a rare case of leukemic evolution as a terminal event of RAEB.
A systematic review of placebo-controlled randomized clinical trials of treatments used in oral lichen planus
Authors: J.M. Zakrzewska, E.S-Y. Chan, M.H. Thornhill
Journal: British Journal of Dermatology (2005)

Journal Article A systematic review of placebo‐controlled randomized clinical trials of treatments used in oral lichen planus Get access J.M. Zakrzewska, J.M. Zakrzewska Department of Oral Medicine, Barts and the London, Queen Mary's School of Medicine and Dentistry, Turner Street, London E1 2AD, U.K. *Division of Evidence‐based Medicine, NMRC Clinical Trials and Epidemiology Research Unit, 10 College Road, Singapore 169851, Republic of Singapore †Department of Dental Diagnostic Science, The University of Texas Health Science Centre, Mail Code 7919, 7703 Floyd Curl Drive, San Antonio, Texas 78229‐3900, U.S.A Prof Joanna M.Zakrzewska. E‐mail: j.m.zakrzewka@qmul.ac.uk Search for other works by this author on: Oxford Academic Google Scholar E.S‐Y. Chan, E.S‐Y. Chan Department of Oral Medicine, Barts and the London, Queen Mary's School of Medicine and Dentistry, Turner Street, London E1 2AD, U.K. *Division of Evidence‐based Medicine, NMRC Clinical Trials and Epidemiology Research Unit, 10 College Road, Singapore 169851, Republic of Singapore †Department of Dental Diagnostic Science, The University of Texas Health Science Centre, Mail Code 7919, 7703 Floyd Curl Drive, San Antonio, Texas 78229‐3900, U.S.A Search for other works by this author on: Oxford Academic Google Scholar M.H. Thornhill M.H. Thornhill Department of Oral Medicine, Barts and the London, Queen Mary's School of Medicine and Dentistry, Turner Street, London E1 2AD, U.K. *Division of Evidence‐based Medicine, NMRC Clinical Trials and Epidemiology Research Unit, 10 College Road, Singapore 169851, Republic of Singapore †Department of Dental Diagnostic Science, The University of Texas Health Science Centre, Mail Code 7919, 7703 Floyd Curl Drive, San Antonio, Texas 78229‐3900, U.S.A Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 153, Issue 2, 1 August 2005, Pages 336–341, https://doi.org/10.1111/j.1365-2133.2005.06493.x Published: 01 August 2005 Article history Accepted: 02 September 2004 Published: 01 August 2005
Pasteurella multocida Septicemia
Authors: Aaron A. Stein
Journal: JAMA (1983)

<i>Pasteurella multocida</i>most commonly infects patients with animal contacts. Life-threatening systemic disease is distinctly uncommon in otherwise healthy persons and usually occurs in patients with chronic predisposing disease. Two cases of sepsis occurred in a cancer hospital, and we surmise that specific predisposing factors existed in our patients as in prior reported cases of sepsis in patients without cancer. These factors include animal contact, open wounds, and, most important, advanced hepatic disease. (<i>JAMA</i>1983;249:508-509)
498 EFFECT OF PROPHYLAXIS FOR VENOUS THROMBOEMBOLISM AFTER LIVER RESECTION IN CIRRHOTIC PATIENTS
Authors: M. Vivarelli, M. Zanello, C. Zanfi, A. Cucchetti, M. Ravaioli, M. Del Gaudio, M. Cescon, A. Lauro, E. Montanari, G.L. Grazi, A.D. Pinna
Journal: Journal of Hepatology (2010)
Histiocytic Lymphoma: Response to Chemotherapy
Authors: J.D. BITRAN
Journal: Annals of Internal Medicine (1982)

Letters and Corrections1 October 1982Histiocytic Lymphoma: Response to ChemotherapyJ.D. BITRAN, M.D., D.L. SWEET, M.D., J. VARDIMAN, M.D., H.M. GOLOMB, M.D., J.E. ULTMANN, M.D.J.D. BITRAN, M.D.Search for more papers by this author, D.L. SWEET, M.D.Search for more papers by this author, J. VARDIMAN, M.D.Search for more papers by this author, H.M. GOLOMB, M.D.Search for more papers by this author, J.E. ULTMANN, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-97-4-617_3 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: Advanced diffuse histiocytic lymphoma is curable when treated with combination chemotherapy (1). There is a small risk (13%) of recurrent lymphoma within the first 36 months in patients with a complete response to chemotherapy. Usually, reinstitution of the initial chemotherapeutic regimen may control recurrent lymphoma. Although patients with nodular lymphoma (follicular center lymphoma) may show conversion to a diffuse histologic form (3), conversion of diffuse histiocytic lymphoma to a nodular histologic form has not been reported.In 1980, we reported the results of treatment with the cyclophosphamide, vincristine, methotrexate with leucovorin rescue, and cytarabine (COMLA) regimen in...References1. SWEETGOLOMBULTMANN DHJ. Cyclophosphamide, vincristine, methotrexate with leucovorin rescue, and cytarabine (COMLA) combination sequential chemotherapy for advanced diffuse histiocytic lymphoma. Ann Intern Med. 1980;92:785-90. LinkGoogle Scholar2. HOPPE R. Histologic variation in non-Hodgkins' lymphomas: commentary. Can Treat Rep. 1981;65:935-9. MedlineGoogle Scholar3. LEYSERVARIAKOJISMINTZVARDIMANULTMANN SDUJJ. Multiple histologic subtypes of non-Hodgkins' lymphoma: clinical and pathologic features. Cancer. 1981;48:2063-9. CrossrefMedlineGoogle Scholar4. KRIKORIANBURKEROSENBERG JJS. Occurrence of non-Hodgkins' lymphoma after therapy for Hodgkins' disease. N Engl J Med. 1979;300:452-8. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: University of Chicago Pritzker School of Medicine Michael Reese Medical Center Albert M. Billings Hospital Chicago, IL 60616 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 October 1982Volume 97, Issue 4Page: 617-618KeywordsChemotherapyCombination chemotherapyCyclophosphamideDiffuse large B-cell lymphomaLymphomaMethotrexate Issue Published: 1 October 1982 PDF downloadLoading ...