tbuckley/cabot-search huggingface dataset:
Omega-3 Fatty Acid Derivative May Help Treat Diabetes
Authors: Tracy Hampton
Journal: JAMA (2014)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Multiple widespread eruptive Spitz naevi
Authors: None Dawe, None Wainwright, None Evans, None Lowe
Journal: British Journal of Dermatology (1998)

A 19-year-old man presented with a widespread eruption of several hundred Spitz naevi. He is still developing new lesions, 4 years after the problem began. No treatment to date has been satisfactory. The literature on prognosis and treatment of this condition is reviewed.
Endoscopic Piecemeal Mucosal Resection Versus Endoscopic Submucosal Dissection for Superficial Esophageal Lesions Larger Than 15 mm
Authors: Quan-Lin Li, Ping-Hong Zhou, Li-Qing Yao, Mei-Dong Xu, Meng-Jiang He, Yi-Qun Zhang, Yun-Shi Zhong, Wei-Feng Chen, Li-Li Ma, Wen-Zheng Qin, Jian-Wei Hu, Ming-Yan Cai
Journal: Clinical Gastroenterology and Hepatology (2013)

Because neither en bloc resection nor assessment of the resection margin can be accomplished in endoscopic piecemeal mucosal resection (EPMR) for large esophageal lesions, the boundary of each snare potentially becomes an origin of recurrence. Endoscopic submucosal dissection (ESD) is now increasingly used for these tumors because of high curative resection rates. However, the technical difficulty of ESD has repeatedly been shown to be associated with higher complication rates. We aimed to evaluate the efficiency and feasibility of ESD compared with EPMR for esophageal superficial lesions ≥15 mm, including an analysis of risks factors for incomplete resection, local recurrence and severe complications in esophageal ESD.
Progress in Gastroenterology
Authors: Sumner C. Kraft
Journal: JAMA (1970)

This book capably reviews selected advances and modern concepts in gastroenterology. The initial 16 chapters are grouped into four sections on the gastrointestinal mucosa, gastric and pancreatic secretions, alimentary motility, and absorption and bacterial flora. The remaining 12 chapters (45% of the text) deal concisely with wide ranging clinical topics such as multiple endocrine adenomas, primary and secondary disaccharidase deficiencies, celiac disease, special problems of pediatric gastroenterology, and the role of the intensive-care unit in clinical gastroenterology. There are 53 contributors from seven countries and most are acknowledged authorities in their respective areas. The format is similar for each chapter, from an opening table of contents to a concluding statement of the shortcomings of available information and projections for the future. The presentations for the most part are well written and carefully edited. Referencing is extensive and up to date, there is a 17-page index, and the text is supplemented
Measles Immunization: New Recommendations
Authors: Saul Krugman
Journal: JAMA (1977)

Live, attenuated measles virus vaccine was licensed for use in the United States in 1963. During the past 13 years, more than 80 million children have been immunized. During the prevaccine era, major epidemics occurred in most cities at two- or threeyear intervals, and the number of reported cases in the United States was approximately 500,000 each year. The extensive use of measles vaccine during the past decade has had a profound effect on the epidemiology of the disease in this country. The number of reported cases has declined to levels of approximately 35,000 per year, a decrease exceeding 90%. In addition, there has been a corresponding reduction in the number of cases of encephalitis following measles cases, and major nationwide epidemics have not occurred. However, despite this encouraging trend, outbreaks of measles have been observed in adolescents as well as in young children during the past four or five
Protests about having to structure time off to enable the NHS to work at weekends as it does in the week may be hypocritical
Authors: K. J. H. Newman
Journal: BMJ (2013)

Yes, the NHS should work at weekends for urgent and emergency care, as Keogh says.1 Putting patients first means adapting work practices to achieve a better service for everyone, including ourselves and our families—we are all potential patients.

Would we want to wait in agony over a …
Alternative cross-priming through CCL17-CCR4-mediated attraction of CTLs toward NKT cell–licensed DCs
Authors: Verena Semmling, Veronika Lukacs-Kornek, Christoph A Thaiss, Thomas Quast, Katharina Hochheiser, Ulf Panzer, Jamie Rossjohn, Patrick Perlmutter, Jia Cao, Dale I Godfrey, Paul B Savage, Percy A Knolle, Waldemar Kolanus, Irmgard Förster, Christian Kurts
Journal: Nature Immunology (2010)
Health Insurance Reform and the Physician-Patient Relationship
Authors: Scott A. Kupor
Journal: JAMA (1993)

To the Editor.  —Parmet's physician-patient relationship 1 provides an interesting and informative glance at an often neglected issue surrounding health care reform. In the discussion of malpractice reform, Parmet makes two claims regarding malpractice suits under a national health insurance program: (1) the frequency of litigation will decline due in part to the fact that 10% of current damage awards are for medical expenses and (2) the severity of damage awards will decline due to elimination of the collateral source rule (total damages will be offset by covered medical expenses). As a result, Parmet writes, jurors are likely to reduce the damages awarded.  The results of studies conducted on collateral source rule elimination, however, temper the optimism of Parmet's conclusion. In a study of the effect of tort reforms on the size and frequency of malpractice claims, Danzon 2 reported that the elimination of the collateral source rule reduced the
Restrictive Left Ventricular Filling Pattern Does Not Result From Increased Left Atrial Pressure Alone
Authors: Satoshi Masutani, William C. Little, Hiroshi Hasegawa, Heng-Jie Cheng, Che-Ping Cheng
Journal: Circulation (2008)

Background— The restrictive filling pattern seen with severe heart failure (HF) may be due to diastolic dysfunction with elevated left ventricular (LV) diastolic pressure or may be merely a manifestation of an overfilled LV as a result of increased left atrial (LA) pressure. We investigated whether the LV restrictive filling pattern is due to elevated LA pressure alone. Methods and Results— We studied conscious dogs instrumented to measure LA pressure, LV pressure, and 3 LV diameters. LV filling dynamics were evaluated in 2 situations with similar elevations of LA pressure: in normal animals after rapid volume loading with dextran 500 mL and in animals with pacing-induced HF with restrictive filling. With HF, there was increased LV chamber stiffness and slow relaxation. Volume loading and HF had similar heart rates (129±19 versus 131±15 bpm) and LA pressure (22.1±5.8 versus 22.6±3.3 mm Hg). The peak early filling rate (E) was increased with both HF and volume loading. However, in HF, the peak mitral annular velocity (E′) was decreased and delayed, and the E deceleration time was shorter. In contrast, with volume loading, E′ was increased and not delayed. Conclusion— The restrictive filling pattern is distinguished from overfilling of a normal ventricle by a reduced and delayed E′ and a shortened E deceleration time that reflect slow relaxation and increased LV stiffness.
Dieting and Peroneal Nerve Palsy
Authors: Stanley F. Wainapel
Journal: JAMA (1978)

<h3>To the Editor.—</h3> The report by Sherman and Easton, "Dieting and Peroneal Nerve Palsy" (238:230-231, 1977), is of considerable interest, but the authors' data on nerve conduction velocity determination and electromyograms (EMGs) are incomplete and possibly inconclusive. In the five patients having these studies, common peroneal motor conduction values ranged from 40 to 52 m/s with a mean of 43.6 m/s, and EMGs showed denervation in only peroneal-innervated muscles. The normal values for motor conduction velocity of the common peroneal nerve reported in the literature are as follows: Thomas et al,<sup>1</sup>49.7±7.1 m/s; Yap and Hirota,<sup>2</sup>45.5±3.2 m/s; Lenman and Ritchie,<sup>3</sup>52.1 ± 4.9 m/s; and Lamontagne and Buchtal,<sup>4</sup>50.0±3.5 m/s. Thus, a value of 40 m/s (the lowest obtained in subjects with footdrop) is within 2 SD of the normal mean by two of the four previously mentioned standards. The electromyographic data presented by Sherman
MCHC in intravascular hemolysis
Authors: Sandra Buys, Catherine Craven
Journal: American Journal of Hematology (1990)

Letter to the Editor: MCHC in lntravascular HemolysisAnemias have been classified by the size and hemoglobin content or red cells.Of the red cell indices, the mean corpuscular volume (MCV) has proven to be the most useful in the classification of anemia.The mean corpuscular hemoglobin concentration (MCHC) generally parallels the MCV, being reduced in iron deficiency anemia and thalassemia, and is reported to be elevated only in spherocytic anemias and certain hemoglobinopathies [2,6].Elevations in the MCHC to greater than 50.0 g/dl were reported in two patients with acute intravascular hemolysis due to clostridial septicemia.This increase was likely spurious due to the presence of extracellular hemoglobin.Experimental data and other cases of hemolytic anemia support this hypothesis.Case 1: A 72-year-old male was admitted with fever and abdominal pain.The hemoglobin (HGB) was 15.3 gidl, red blood cell count (RBC) 4.96 X 10l2/L, hematocrit (HCT) 46.1%, MCV 93 fl, mean corpuscular hemoglobin (MCH) 30.8 pg, MCHC 33.2 g/dl, white cell count (WBC) 6.1 X 109/L, and platelet count (Plt) 139 X 109/L.Over the next few hours he began to bleed around the intravenous catheters, and the urine became dark.Repeat HGB was 7.8 g/dl, RBC 1.95 x 10l2/L, HCT 14.0%, MCV 71 fl, MCH 39.9 pg, MCHC 56.1 g/dl, WBC 15.6 X 109/L, Plt 48 X 109/L, prothrombin time (PT) 30.2 sec, and partial thromboplastin time (PTT) 63 sec.Blood cultures grew Clostridium perfringens.He became hypotensive and died.At autopsy, an acute clostridial hepatic abscess was detected.Case 2: A 76-year-old male was admitted with fever and abdominal pain.The HGB was 1 1.6 g/dl, RBC 2.9 X lO'*/L, HCT 23.0%, MCV 80 fl, MCH 40 pg, MCHC 50.1 g/dl, WBC 26.6 X 109/L, and Plt 37 x 109/L.He died with a cardiac arrest.At autopsy, acute cholecystitis and a clostridial hepatic abscess were identified.Blood cultures grew Clostridium perlfringens.
Primary Liver Tumors and Oral Contraceptives
Authors: Josef Vana
Journal: JAMA (1977)

Data on 378 (in females) and 165 (in males) cases of primary liver tumors reported by 477 hospitals in the United States during 1970 to 1975 show that in males, 91.5% of the tumors were malignant, and in females, 43.9% were malignant and 56.1% were benign. Of the 212 benign tumors in females, 96 were hepatic cell adenomas and 58 were focal nodular hyperplasias. A history of oral contraceptive use was found in nearly half of all women: 65% with benign tumors, 74% with hepatic cell adenomas, and 74% with focal nodular hyperplasias. Symptoms were more severe among users. No case of intraperitoneal bleeding was observed in nonusers. The findings confirm the suggested association between oral contraceptive use and hepatic cell adenomas and focal nodular hyperplasias. (<i>JAMA</i>238:2154-2158, 1977)
(32) Subcorneal pustulation
Authors: A. Taaffe, A. Knight
Journal: British Journal of Dermatology (1977)

Journal Article (32) Subcorneal pustulation Get access A. Taaffe, A. Taaffe University Hospital of Wales, Cardiff Search for other works by this author on: Oxford Academic Google Scholar A. Knight A. Knight University Hospital of Wales, Cardiff Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 97, Issue s15, 1 December 1977, Pages 69–70, https://doi.org/10.1111/j.1365-2133.1977.tb14340.x Published: 01 December 1977
Human epidermal Langerhans cells express the high affinity receptor for immunoglobulin E (Fc epsilon RI).
Authors: T Bieber, H de la Salle, A Wollenberg, J Hakimi, R Chizzonite, J Ring, D Hanau, C de la Salle
Journal: The Journal of Experimental Medicine (1992)

It has been suggested that epidermal Langerhans cells (LC) bearing immunoglobulin E (IgE) may be involved in the genesis of atopic disease. The identity of the IgE receptor(s) on LC remained unclear, although it represents a crucial point in understanding cellular events linked to the binding of allergens to LC via IgE. In this report, we demonstrate that epidermal LC express the high affinity receptor for the Fc fragment of IgE (Fc epsilon RI) which has, so far, only been described on mast cells and basophils. Epidermal LC react with antibodies specific for the alpha subunit of the tetrameric (alpha, beta, 2 gamma) Fc epsilon RI. Specific transcripts for Fc epsilon RI alpha and Fc epsilon RI gamma were detected in LC and correspond to those of human basophils and of the human basophil cell line KU812. Furthermore, human basophils, KU812 cells, and LC express the putative beta subunit. Thus human LC express the complete structure of Fc epsilon RI. This finding opens new perspectives in the putative functional role of this structure on antigen-presenting cells.
Left ventricular systolic and diastolic function in coronary artery disease: effects of revascularization on exercise-induced ischemia.
Authors: J D Carroll, O M Hess, H O Hirzel, M Turina, H P Krayenbuehl
Journal: Circulation (1985)

Left ventricular systolic and diastolic function were studied before and after surgical revascularization in a group of 24 patients with stable angina who all had an excellent clinical response to surgery. With use of micromanometer left ventricular pressure measurements and ventricular volumes, calculated from biplane cineangiograms, left ventricular function at rest and during exercise before and after surgery was compared. Before surgery all patients had exercise-induced ischemia with new asynergy, a fall in ejection fraction from 57% to 49% (p less than .001), and a rise in left ventricular end-diastolic pressure from 23 to 37 mm Hg (p less than .001). Postoperative exercise resulted in no new asynergy and ejection fraction rose from 59% to 61% (p less than .05). Left ventricular end-diastolic pressure still rose from 17 to 25 mm Hg (p less than .01). Left ventricular pressure decay during exercise was greatly improved after revascularization and allowed maintenance of reduced early diastolic pressures. The early diastolic pressure nadir before surgery rose from 9 to 21 mm Hg (p less than .001); the postoperative nadir was 5 mm Hg at rest and 6 mm Hg during exercise. All patients had an upward shift in the diastolic pressure-volume relationship during preoperative exercise. After revascularization there was no upward shift in some patients and a much smaller shift in others. The postoperative increase in left ventricular end-diastolic pressure was due to increased end-diastolic volume, not altered compliance. There was an increase in mean right atrial pressure during exercise either before (6 to 11 mm Hg) or after surgery (4 to 10 mm Hg). These increases were quite variable, suggesting no consistent role of pericardial restraint during exercise. Early diastolic peak filling rate during exercise was greater after surgery (1260 vs 950 ml/sec, p less than .001). In fact, during postoperative exercise early diastolic filling rates were greater than normal, reflecting the persistence of abnormally high atrial pressures for filling. As at preoperative study, late diastolic filling during exercise was restricted after revascularization when compared with that in a control group. Postoperatively patients undergoing bypass procedures with a good clinical result showed significantly improved left ventricular diastolic and systolic function. Persistent elevation of end-diastolic and atrial pressures and other abnormalities of diastolic function may reflect chronic structural changes and need to be taken into account when evaluating patients after bypass surgery.
Absorption Kinetics and Action Profiles After Sequential Subcutaneous Administration of Human Soluble and Lente Insulin Through one Needle
Authors: Henk J Bilo, Robert J Heine, Anneke C Sikkenk, Jan van der Meer, ED A van der Veen
Journal: Diabetes Care (1987)

The effects of sequential administration through one needle of human soluble and human lente insulin on plasma insulin levels and action profiles, assessed with glucose clamping, were studied in six healthy volunteers. Insulin kinetics after administration of human soluble insulin (0.22 IU/kg) alone were compared with those after sequential administration of 1) human soluble insulin followed by human lente insulin and 2) human lente insulin followed by human soluble insulin. Total insulin dose in both sequences was 0.55 IU/kg, 40% of which was short-acting insulin. Plasma insulin levels were not significantly different at any time point between 0 and 240 min after soluble insulin compared with either combination. Although insulin levels were slightly but significantly lower at 30 and 105 min after lente followed by soluble insulin compared with soluble followed by lente insulin, these differences probably reflect chance occurrences. Glucose requirements were not significantly different after either of the three administrations. We therefore conclude that the unwanted retarding effect after mixing of human soluble insulin with human lente insulin in the syringe on the onset of action of the soluble insulin can be prevented by sequential subcutaneous injection of these insulins with two syringes through one needle.
Immunity Against Zymotic Diseases.
Authors: CORBAN E. JUDD
Journal: JAMA (1901)

Topeka, Kans., April 18, 1901. <h3>To the Editor:</h3> —I have read, with appreciation, the article on "Immunity Against Zymotic Diseases," by Dr. J. W. Class, published inThe Journalof April 13, and have been much impressed by the author's lucid exposition of what is generally considered a perplexing theme. The rather unique theory advanced by the author particularly attracted my notice, because its essential features had all been presented and elaborated in a paper of similar import, read Feb. 18, 1901, before the Medical Science Club of Topeka, by Dr. O. P. Davis, of this city, the original of which is in my keeping as secretary of that organization. In this paper, Dr. Davis, after canvassing the various theories of immunity, and pointing out their insufficiency, arrives by a process of deductive reasoning at what seems to be a new and plausible theory embracing all that Dr. Class sets
Research Policy: Selectivity by the UGC: a taste of things to come
Authors: R. Smith
Journal: BMJ (1988)

In 1986 for the first time the grants that universities received from the University Grants Committee were related to ratings of the research effort of their various departments. Such selectivity was effectively forced on the UGC by the cuts in its budget. The mechanism used to grade the departments was only half explained, and the results were never published collectively. Yet the results of the gradings were collected together haphazardly by some groups and publications, and many departments thought that they had been misjudged. Many academics objected particularly to the fact that it was impossible to validate the exercise because the methods used were inadequately described. Smith, a geographer, has written:
Infectious CNS disease as a differential diagnosis in systemic rheumatic diseases: three case reports and a review of the literature
Authors: K Warnatz, H H Peter, M Schumacher, L Wiese, A Prasse, F Petschner, P Vaith, B Volk, S M Weiner
Journal: Annals of the Rheumatic Diseases (2002)

Immunosuppressive treatment of rheumatic diseases may be associated with several opportunistic infections of the brain. The differentiation between primary central nervous system (CNS) involvement and CNS infection may be difficult, leading to delayed diagnosis.To differentiate between CNS involvement and CNS infection in systemic rheumatic diseases.Three patients with either longstanding or suspected systemic rheumatic diseases (systemic lupus erythematodes, Wegener's granulomatosis, and cerebral vasculitis) who presented with various neuropsychiatric symptoms are described. All three patients were pretreated with different immunosuppressive drugs (leflunomide, methotrexate, cyclophosphamide) in combination with corticosteroids. Magnetic resonance imaging of the brain was suggestive of infectious disease, which was confirmed by cerebrospinal fluid analysis or stereotactic brain biopsy (progressive multifocal leucoencephalopathy (PML) in two and nocardiosis in one patient).More than 20 cases of PML or cerebral nocardiosis in patients receiving corticosteroids and cytotoxic drugs for rheumatic disease have been reported. The clinical aspects of opportunistic CNS infections and the role of brain imaging, cerebrospinal fluid analysis and stereotactic brain biopsy in the differential diagnosis are reviewed.
RADIATION EXPOSURE DURING TRANSCATHETER AORTIC VALVE IMPLANTATION (TAVI) PROCEDURES
Authors: Benoit Daneault, Stephen Balter, Susheel Kodali, Mathew Williams, Philippe Genereux, Marian Hawkey, Susan Schnell, Ajay Kirtane, Craig Smith, Jeffrey W. Moses, Martin B. Leon
Journal: Journal of the American College of Cardiology (2011)
Prevention of Aspiration of Gastric Contents during General Anesthesia
Authors: Samuel Gilman, Arthur L. Abrams
Journal: New England Journal of Medicine (1956)

ASPIRATION of gastric contents into the respiratory tract by the unconscious patient is a serious, and sometimes a fatal, hazard. In a series of 44,016 pregnancies studied at the New York Lying-in Hospital, Mendelson1 reported 66 cases of aspiration of gastric contents into the pulmonary tree. Hingson and Hellman,2 in 1951, analyzed 330 maternal deaths resulting from anesthesia and found aspiration of vomitus responsible for 155. The dangers of aspiration of stomach contents during general anesthesia have been documented by others.3 , 4 Although the hazard of aspiration of gastric contents from a stomach known to be full is well recognized, the . . .
Heparin induced extracorporeal IDL-precipitation (help) promotes regression (REG) in patients with familial hypercholesterolemia II (FH)
Authors: Helmut Gohlke, Kurt Braunagel, Hans-Peter Bestehorn, Uli Kettner, Elke Burggraf, Monika Bauer, Peter Betz, Helmut Roskamm
Journal: Journal of the American College of Cardiology (1991)