tbuckley/cabot-search huggingface dataset:
Advice that shaped my practice: Doctor who?
Authors: Charles Essex
Journal: BMJ (2006)

“Wear a badge and introduce yourself,” I was told on my first morning on the wards as a medical student. This was in the 1970s, which, we keep being reminded, were the Dark Ages of doctor-patient communication—unlike today when medical students and young doctors get training in communication skills. The doctor added, “You are going to ask some very personal questions and do some very intimate things. The least you can do is tell the patient who you are.”

Name badges used to have safety-pin fastenings, which made holes in your clothes or white coat. The modern clip-on badges avoid that. The disadvantage is that they can be clipped to belts or trouser pockets, where they can be read only by people of very short stature or with a severe scoliosis. Doctors and medical students seem to be the worst culprits in the NHS for wearing their badges in unreadable—and therefore unhelpful—places.

Here is a project for someone. Why do medical students and doctors wear name badges in places where they cannot be read? Do you think you look like a nerd having a name badge clipped to your tie or breast pocket? It looks cool wearing your name badge on your hip? Is it fear of being identified and held accountable for what you have said and done? Parents can tell me only that, “A young doctor on the ward said...” Doctor who?

At a recent outpatient appointment the consultant surgeon was superb. He introduced himself and wore a name badge where I could read it. When I was subsequently admitted for day surgery I was clerked in (twice) and had blood taken by two house officers and a medical student—graduates and an undergraduate, respectively, of a medical school which claims to emphasise communication skills. None introduced himself or herself, none wore a name badge in a place that I could read it easily.

I have never forgotten that advice on my first clinical day. Although my patients' parents know who I am because they get an appointment letter with my name, as consultant, on it, I always introduce myself (and anyone else who is present) when they enter the room. It has paid dividends in starting the consultation off on the right note. And I wear my name badge where people can read it.

Students and junior doctors know to do this at my clinics—or they learn within the first 30 seconds. The next time I see them, they have reverted to their badge-on-hip style. So what does that prove? You can lead a horse to water but you can't make it do synchronised swimming? A colleague suggested that junior doctors are like teenagers, and it is a phase they go through. Not in my clinics and not at my patients' expense. Patients entrust us with their lives. As a paediatrician, I am entrusted with parents' most treasured possession in the world. The least we can do is tell the parents who we are and wear a badge to remind them if they forget.
Abstract 12639: A New Prognostic Index for Acute Heart Failure and Non-arrhythmic Death in Subjects with a Cardiac Defibrillator and Ischemic Cardiomyopathy
Authors: Lanfranco Antonini, Cristina Mollica, Antonio Auriti, Vincenzo Pasceri, Christian Pristipino, Furio Colivicchi, Francesco Mele, Massimo Santini
Journal: Circulation (2011)

Subjects suffering from ischemic cardiomyopathy receiving a defibrillator (ICD) are still at high risk of heart failure and non-arrhythmic death. Predictors of increased risk are lacking in these p...
Abstract 360: Genetic Deletion of IL-6 Ameliorates Left Ventricular Dysfunction and Remodeling after a Reperfused Myocardial Infarction
Authors: Hisham Taher, Yiru Guo, Santosh K Sanganalmath, Smita Ranjan, Robert J Vincent, Wen-Jian Wu, Wei Tan, Xiaoping Zhu, Greg Hunt, Christine R James, Roberto Bolli, Buddhadeb Dawn
Journal: Circulation (2008)
Current Therapy. Latest Approved Methods of Treatment for the Practicing Physician.
Authors: Dwight L. Wilbur
Journal: Annals of Internal Medicine (1983)

This book represents an attempt to provide for the practitioner the latest method of treatment for a variety of diseases. A board of twelve consulting editors and over two hundred physicians have contributed to the book. The contents are divided into fourteen sections: Infectious diseases, diseases of the digestive system, diseases of metabolism and nutrition, diseases of the endocrine system, diseases of the urogenital tract, venereal diseases, diseases of allergy, diseases of the skin, diseases of the respiratory system, diseases of the cardiovascular system, diseases of the blood and spleen, diseases of the nervous system, obstetric and gynecologic diseases and diseases due to physical and chemical agents. The discussions are brief, with a minimum of wasted words. However, the essentials of the method of treatment proposed by the contributors are sufficiently complete for the reader to obtain a clear understanding of the therapeutic problem. This book does not present a
Abstract 5988: Can We Reduce the Use of DES without Compromising Efficacy? Results of a Strategy Combining a Simple Selection Process and the Use of Thin Strut Cobalt Chromium Bare Metal Stents
Authors: Pieter Stella, Hendrik Nathoe, Siyrous HoseyniGuyomi, Thierry Wildbergh, Huub W Meijburg, Pieter A Doevendans, Eric van Belle
Journal: Circulation (2008)

The introduction of drug eluting stents (DES) has been a breakthrough in the prevention of restenosis following PCI. However, the high rates of late stent thrombosis observed with these devices make alternative preventive strategies mandatory. The use of thin struts cobalt chromium (TSCC) bare metal stents has been associated with promising clinical results. We hypothesized that the use of a strategy combining a simple selection of clinical indications and the use of TSCC BM stents could achieve very low restenosis rates without compromising safety. From September 2005 to June 2006, among patients referred for a PCI procedure in our centre, we prospectively selected those in which at least one of the 2 inclusion criteria was met: de novo coronary lesion not exceeding 20 mm in length; vessel diameter more than 2.6 mm; and excluded those with diabetes mellitus unless vessel diameter &gt; 3.5 mm; to undergo implantation of TSCC bare metal stents. Twelve months follow-up was obtained in all patients. 511 patients; 30% of the total population referred for PCI; matched the selection criterions and were part of the study. Despite the selection process, the study population was at relatively high risk including 22% of patients with a history of MI, 50% with multivessel coronary artery disease and 59% undergoing PCI for an acute coronary syndrome. The procedural success rate was 99.6%. A single stent was implanted in 88% of patients. A peri-procedural myocardial infarction occurred in 7 (1.4 %) patients. Clinically driven TLR and TVR at 12 months were observed in 8 (1.6%) and 13 (2.5%) patients, respectively. Cumulative In stent-thrombosis at 1 and 12 months occurred in 4 (0.08%) and 6 (0.1%) patients, respectively. Our results demonstrate that a simple selection process, applying to 30% of a routine PCI population, combined with the use of TSCC bare metal stents can be associated with a very favourable long-term clinical outcome. The use of TSCC bare metal stents is an attractive alternative to DES in such a population.
Abstract 17124: Utility of Magnetocardiography for Evaluating Arrhythmogenic Right Ventricular Cardiomyopathy
Authors: Yoshitaka Kimura, Yuko Yamada, Hiroshi Takaki, Shuji Hashimoto, Ikutaro Nakajima, Koji Miyamoto, Hideo Okamura, Takashi Noda, Kazuhiro Satomi, Takeshi Aiba, Wataru Shimizu, Shirou Kamakura, Masaru Sugimachi
Journal: Circulation (2012)

Signal averaged ECG (SAECG) is an important tool for noninvasively detecting arrhythmogenic substrates in arrhythmogenic right ventricular cardiomyopathy (ARVC), however, its value is seriously lim...
Abstract 8880: Senescence Marker Protein 30 Inhibits Angiotensin II-induced Cardiac Remodeling
Authors: Tomofumi Misaka, Satoshi Suzuki, Makiko Miyata, Atsushi Kobayashi, Shu-ichi Saitoh, Yasuchika Takeishi
Journal: Circulation (2011)

Backgrounds: Aging is a major risk factor of cardiovascular diseases including heart failure. Senescence marker protein 30 (SMP30) is originally identified as an important aging marker protein, which the expression decreases androgen-independently with aging. SMP30 may act as an anti-aging factor in various organs, but the functional role of SMP30 in the heart has not been investigated. Purpose: We tested the hypothesis that SMP30 functions as cardio-protective by anti-aging effects in angiotensin II (Ang II) -induced cardiac remodeling. Methods and Results: SMP30 knockout mice (KO) and wild-type mice (WT) were subjected to continuous Ang II infusion (800 ng/kg/min). After 14 days, the extent of cardiac hypertrophy and myocardial fibrosis were significantly higher in SMP30 KO mice than in WT mice (P&lt;0.01, respectively). Echocardiography revealed that SMP30 KO mice had more severely impaired systolic and diastolic function with remarkably enlarged left ventricular dimension compared to WT mice (Table). Generation of reactive oxygen species related with activation of NADPH oxidase was greater in SMP30 KO mice than in WT mice (P&lt;0.01). The numbers of TUNEL positive nuclei were markedly increased in SMP30 KO mice compared to WT mice (P&lt;0.01). In addition, activation of signaling pathways leading to apoptosis such as increases in caspase-3 activity, Bax/Bcl-2 ratio and phosphorylation of c-Jun N-terminal kinase were observed in SMP30 KO mice compared with WT mice (P&lt;0.01, for each). The numbers of senescence-associated β-galactosidase-positive cardiomyocytes were increased via upregulation of p21 gene expression in SMP30 KO mice compared to WT mice (P&lt;0.01). Conclusions: This study demonstrates the first evidence that deficiency of SMP30 exacerbates Ang II-induced cardiac hypertrophy, dysfunction and remodeling. These findings suggest that SMP30 has a cardio-protective role as anti-aging factor by anti-oxidative and anti-apoptotic effects in the heart.
Accuracy of In Vivo Coronary Plaque Morphology Assessment
Authors: Kenya Nasu, Etsuo Tsuchikane, Osamu Katoh, D. Geoffrey Vince, Renu Virmani, Jean-François Surmely, Akira Murata, Yoshihiro Takeda, Tatsuya Ito, Mariko Ehara, Tetsuo Matsubara, Mitsuyasu Terashima, Takahiko Suzuki
Journal: Journal of the American College of Cardiology (2006)
Abstract 8302: Lidocaine Abolishes the Sympathetic and Blood Pressure Responses in Limb Venous Distension Reflex
Authors: Jian Cui, Patrick McQuillan, Lawrence I Sinoway
Journal: Circulation (2011)

Introduction- We have recently shown that saline infusion into the veins of an arterially occluded human forearm evokes a systemic response with an increase in muscle sympathetic nerve activity (MSNA) and blood pressure (BP). Hypothesis- Limb veins distension per se activates afferent nerves within (or close to) the vessel wall, and evokes a systemic sympathoexcitatory reflex. Methods- Thus, we examined MSNA and BP responses as albumin was infused into the venous circulation of an arterially occluded forearm. These MSNA and BP responses were compared with those seen with a saline infusion. Albumin preferentially remains within the vascular space whereas saline distributes within the entire limb extracellular space. BP (Finometer), heart rate, and MSNA (microneurography) were assessed in 14 young healthy subjects on 3 separate visits. In the saline trial, 5% forearm volume saline was infused into an arterially occluded arm. In the albumin trial (n=11), the same volume of albumin solution (5% concentration) was infused. In separate studies, 90 mg of lidocaine was added to the saline infusion (n=6). Results- MSNA and mean BP rose towards to the end of infusion in both saline and albumin trials. A larger (i.e. the peak response at the end of infusion: delta 14.3±2.7 vs. delta 8.5±1.3 bursts/min, P &lt;0.01) and a sustained (i.e. the 30-60 sec of post infusion: delta 15.0±3.0 vs. delta 5.9±2.4 bursts/min, P &lt;0.05) MSNA response was noted with albumin infusion as compared to saline infusion. The BP response with albumin infusion was also greater and sustained than saline infusion (all P &lt;0.05). The 90 mg of lidocaine added to the saline infusion abolished &gt;90% of the MSNA and BP responses. Discussion and Conclusion- These data suggest that vein distension is crucial to evoking the response seen. The lidocaine trial confirms that this venous distension evokes an autonomic reflex. We suggest that venous distension importantly contributes to autonomic and cardiovascular control in humans.
Rapid In Vivo Assay for Friend Polycythemia Virus 23
Authors: W. David Hankins, Sanford B. Krantz
Journal: JNCI Journal of the National Cancer Institute (1974)

Journal Article Rapid In Vivo Assay for Friend Polycythemia Virus Get access W. David Hankins, W. David Hankins Search for other works by this author on: Oxford Academic PubMed Google Scholar Sanford B. Krantz Sanford B. Krantz Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 52, Issue 4, April 1974, Pages 1223–1229, https://doi.org/10.1093/jnci/52.4.1223 Published: 01 April 1974 Article history Received: 26 September 1973 Accepted: 18 December 1973 Published: 01 April 1974
Abstract 11708: Increased CK Levels on High Dose Atorvastatin are Related to Decreases In Muscle Strength but do not Predict Myalgia
Authors: Donna Chelle V Morales, Beth Parker, Paul D Thompson
Journal: Circulation (2012)

Introduction Recent results from the randomized, double-blind Effect of Statins on Skeletal Muscle Performance (STOMP) study indicated that subjects treated with 80 mg atorvastatin for six months e...
Abstract 18129: Risk Factors of the Progression from Paroxysmal or Persistent to Permanent Atrial Fibrillation. Evaluation of the HATCH Score in a Cohort of Unselected Patients.
Authors: Laurent Fauchier, Emilie Nonin, Laurent Gorin, Anne Bernard, Bernard Charbonnier, Dominique Babuty
Journal: Circulation (2010)

Recently, the HATCH score has been proposed to identify patients with atrial fibrillation (AF) likely to progress to sustained forms of AF. It was also suggested that the score should be validated in another population of AF patients. Our objective was thus to evaluate the HATCH score in a large contemporary series of unselected AF patients in clinical practice and to identify other possible factors leading to permanent AF.   Methods:  All patients with AF seen in our institution between 2000 and 2007 were identified in a database and followed up for mortality. HATCH socre — acronym for hypertension, age >75, TIA or stroke (2 points), chronic obstructive pulmonary disease and heart failure (2 points) — was calculated for each patient.   Results:  Among 4058 patients with a follow-up > 30 days (age 71±14 years; 2523 men [62%]), 2167 had paroxysmal AF, 220 had persistent AF, and 1671 had permanent AF. During a follow-up of 946±767 days, 553 of them died. Permanent AF was associated with a higher risk of death compared to paroxysmal AF (relative risk=1.45, 95% CI 1.30–1.62) and persistent AF (relative risk=2.8, 95%CI 2.16–3.81) (both p   Conclusions:  In patients with paroxysmal or persistent AF, progression to permament AF is associated with a worse prognosis. The HATCH score seems an appropriate tool to identify the risk of evolution to permanent AF and may be improved if one also considers the presence of prosthetic heart valve or dilated cardiomyopathy. Considering the nature of these factors, one may conjecture that an early optimization of the treatment of heart failure may help to maintain sinus rhythm and may lead to a better survival.
Abstract 5536: Mechanisms Underlying Coronary Vasopsasm at Distal Arterial Segments of Sirolimus-Eluting Stent Implantation in a Porcine Model
Authors: Tetsuya Matoba, Kensuke Egashira, Seigo Masuda, Eiko Iwata, Miho Miyagawa, Kaku Nakano, Noriaki Tsukie, Kenji Sunagawa
Journal: Circulation (2008)

The use of sirolimus-eluting stent (SES) presents serious safety concerns including increased late stent thrombosis and coronary vasospasm that may cause coronary adverse events. Hence we assessed ...
Abstract 1928: Impaired Endocytosis of TRPM4 Channel Associated With Progressive Familial Heart Block Type I
Authors: Martin Kruse, Eric Schulze-Bahr, Valerie Corfield, Alf Beckmann, Birgit Stallmeyer, Guven Kurtbay, Iris Ohmert, Ellen Schulze-Bahr, Paul Brink, Olaf Pongs
Journal: Circulation (2009)

Progressive familial heart block type I (PFHBI) is a dominantly inherited cardiac bundle-branch disorder that has previously been mapped to chromosome 19q13. Here we show that a mutation in the gen...
Psychiatric syndromes linked to reproductive function in women: a review of current knowledge
Authors: M J Gitlin, R O Pasnau
Journal: American Journal of Psychiatry (1989)

Four psychiatric syndromes related to reproductive function in women have been identified: postpartum depression, premenstrual syndrome (PMS), post-hysterectomy depression, and involutional melancholia. The authors review what is known about these syndromes and conclude, first, that postpartum depression comprises three separate syndromes, the most severe of which is most likely a variant of primary affective disorder. Second, research into the syndromal nature, biology, and treatment of PMS is still in its infancy due to a variety of methodological difficulties. Third, the rate of depression among women during the involutional period or following hysterectomy for benign pathology is not higher than it is at other times.
Abstract 3709: Intravenous GP531, an Adenosine Regulating Agent, Improves Left Ventricular Function in Dogs With Chronic Heart Failure
Authors: Mengjun Wang, Itamar Ilsar, Ramesh C Gupta, Alice Jiang, Michael S Sabbah, Kaitlin Dye, Hani N Sabbah
Journal: Circulation (2009)

Background: Adenosine Regulating Agents (ARAs) are compounds that selectively increase local endogenous adenosine release during episodes of cellular stress in which ATP breakdown exceeds ATP synth...
Abstract 3114: Antiplatelet Therapy Use and the Risk of Venous Thromboembolic Events in the Double-Blind Raloxifene Use in The Heart (RUTH) Trial
Authors: Claire S Duvernoy, Adeline A Yeo, Mayme Wong, David A Cox, Hyungin M Kim
Journal: Circulation (2007)

Background: Raloxifene (RLX) use in postmenopausal women (PMW) with osteoporosis increases risk of venous thromboembolic events (VTE) 2-fold, compared to placebo (PL). Platelet activation is involved in the pathophysiology of arterial thromboses more than venous thromboses, but some data suggest that aspirin may reduce VTE risk associated with estrogen use. This analysis examines the effects of concomitant antiplatelet (AP) therapy on VTE risk in RLX-treated women. Methods: In RUTH, 10,101 PMW with coronary heart disease (CHD) or increased risk of CHD were randomized to either PL or RLX 60 mg/d and followed for a median 5.6 yr. Reports of clinical symptoms of VTE were supported by relevant diagnostic data and adjudicated. Concomitant use of AP agents (aspirin, clopidogrel, ticlopidine, dipyridamole) was allowed. Cox proportional hazard models, with use of warfarin, presence of fracture, and/or hospitalization as covariates, were used to estimate hazard ratios (HR) with 95% confidence intervals (CI). Results: Overall, RLX 60 mg/d use was associated with an increased VTE risk [HR 1.44 (95% CI 1.06 –1.95)] from PL. Most women (71%) reported using aspirin, and 14.2% reported using non-aspirin AP agents. VTE risk was similar (HR = 1.04, Table ) for women who used RLX alone versus those who used RLX with AP agents. The increase in VTE risk with RLX compared to PL was similar between women who used any AP prior to VTE and those who did not (interaction P=0.29). Women who used aspirin prior to VTE had a similar increased VTE risk with RLX from PL [HR 1.57(95% CI 1.00 –2.47)], compared to women who did not use aspirin [HR 1.34 (95% CI 0.89 –2.01)] (interaction P=0.62). Conclusion: In RUTH, PMW with CHD or at high risk of CHD treated with RLX had an increased risk of VTE compared to PL. Concomitant use of aspirin or non-aspirin AP agents with RLX therapy did not lower VTE risk from RLX alone.
Abstract P091: Temporal Trends in Incidence of Acute Myocardial Infarction and Revascularization in People With and Without Mental Illness
Authors: Lauren Bresee, Marcello Tonelli, Braden Manns, Brenda Hemmelgarn
Journal: Circulation (2012)

Objective: The objective of this study was to evaluate the temporal trends in the incidence of acute myocardial infarction (AMI) and receipt of revascularization procedures in people with and without mental illness. Hypothesis: Individuals with mental illness will have higher rates of AMI, and lower rates of revascularization compared to people without mental illness. Methods: We did a population-based study using provincial administrative data from April 1, 1998 until March 31, 2009. We identified individuals 20 years of age and older as having mental illness (psychotic disorder [PD] or mood disorder [MD]) based on physician billing claims and hospitalization data, and compared them to those without mental illness by this definition. We identified incident AMI using a validated algorithm applied to hospitalization data. We used procedure codes to identify receipt of cardiac catheterization, coronary artery bypass grafting (CABG), or percutaneous transluminal coronary angioplasty (PTCA) in those with incident AMI. Rates were age-adjusted using the 2001 Canadian census population to perform direct standardization. Relative change over time was calculated by comparing rates in 2009 to rates in 1998. Results: A total of 3,639,480 subjects were included, of whom 576,411 (15.8%) had a mood disorder only, 38,116 (1.0%) had a psychotic disorder only, and 72,430 (2.0%) had both a MD and PD. People with MD were more likely to be female, whereas those with PD were older, than the other mentally ill and non-mentally ill populations. Incidence of AMI was highest in people with PD (210 per 100,000 in 2009) and lowest in people without mental illness (160 per 100,000 in 2009), however, incidence of AMI decreased over time in all groups. Use of catheterization decreased over time in people with MD (19% relative decrease) and PD (25% relative decrease), while increasing in people without mental illness (10.8% relative increase). Use of PTCA increased in all groups except people with PD (21.1% relative decrease). Conclusions: Incidence of AMI decreased over time in people with and without mental illness, however, people with mental illness consistently had a higher incidence of AMI compared to individuals without mental illness. Use of catheterization and PTCA increased in people without mental illness while decreasing in people with PD over the study period.
Abstract 3951: Let-7/miR-98 Family Regulates the Expression of GLUT4 by Targeting MEF-2C in Metabolic Control of Cardiomyocytes
Authors: Naoya Sowa, Koh Ono, Takahiro Horie, Yoshitaka Iwanaga, Hitoo Nishi, Kazuya Nagao, Minako Kinoshita, Rieko Takanabe-Mori, Toru Kita, Takeshi Kimura, Koji Hasegawa
Journal: Circulation (2009)

MicroRNAs (miRNAs) are small, non-protein-coding RNAs that recognize target sequences of imperfect complementarity in cognate mRNAs and inhibit protein translation. Growing evidence indicates that ...