THE PROVOCATIVE SEROLOGICAL REACTION IN LATE SYPHILIS: ITS RELATION TO TECHNICAL FACTORS
Authors: R W MAXWELL, V SCOTT
Journal: Annals of Internal Medicine (1952)

Article1 April 1952THE PROVOCATIVE SEROLOGICAL REACTION IN LATE SYPHILIS: ITS RELATION TO TECHNICAL FACTORSRICHARD W. MAXWELL, M.D., VIRGIL SCOTT, M.D.RICHARD W. MAXWELL, M.D.Search for more papers by this author, VIRGIL SCOTT, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-36-4-979 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptWith the simplification of treatment as the result of the demonstrated efficacy of penicillin, the major problem in clinical syphilis at the present time is the differentiation of positive serologic tests due to syphilis from those due to biologic false-positive reactions. The occurrence of "acute" or shortlived false-positive reactions following certain diseases and conditions such as malaria, infectious mononucleosis, viral pneumonia, smallpox vaccination and many others is well known. Ordinarily, false-positive reactions due to these causes revert spontaneously to negative in periods of days, weeks or, at most, a few months. In addition, it has long been suspected that "chronic"...Bibliography1. Kahn RL: Technique of standard Kahn test and of special Kahn procedures, 1946, University of Michigan Press, Ann Arbor. Google Scholar2. ScottReinSchambergMoore VCRILJE: The serologic differentiation of syphilitic and false positive sera, Am. J. Syph., Gonor. and Ven. Dis. 29: 505, 1945. Google Scholar3. EricksonEagle PTH: Spirochete complement-fixation reaction compared with the Eagle and Wassermann procedures, Ven. Dis. Inform. 21: 31, 1940. Google Scholar4. Pangborn MC: A new serologically active phospholipid from beef heart, Proc. Soc. Exper. Biol. and Med. 48: 484, 1941. CrossrefGoogle Scholar5. NeurathVolkinCraigErickson HEHWJO: Biologic false positive reactions in serologic tests for syphilis. V. 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Kampmeier RH: Essentials of syphilology, 1944, J. B. Lippincott Co., Philadelphia, pp. 40, 41. Google Scholar19. Kolmer JA: Clinical diagnosis by laboratory examinations, 2nd Ed., 1949, Appleton-Century-Crofts, Inc., New York, p. 551. Google Scholar20. DattnerThomas BEW: The management of neurosyphilis, Am. J. Syph., Gonor. and Ven. Dis. 26: 21, 1942. Google Scholar21. DattnerThomasDeMello BEWL: Criteria for the management of neurosyphilis, Am. J. Med. 10: 463, 1951. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: St. Louis, Missouri*Received for publication July 9, 1951.From the Departments of Internal Medicine and Preventive Medicine, Washington University, and the Syphilis Clinic of the Washington University Clinics. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byFurther Progress in Venereology 1 April 1952Volume 36, Issue 4Page: 979-991KeywordsBiologicsInfectious diseasesMalariaPenicillinPreventive medicineSyphilisViral diseasesViral pneumonia ePublished: 1 December 2008 Issue Published: 1 April 1952 PDF downloadLoading ...