tbuckley/cabot-search huggingface dataset:
Hotlines and Youth Culture Values
Authors: PAUL TOROP, KAREN TOROP
Journal: American Journal of Psychiatry (1972)

Hotlines represent a coalescence of the traditional and the counter-culture models of crisis intervention. Hotline staff members who are oriented toward counter-culture values tend to relate easily to callers in a nondirective, nonauthoritarian manner. But in their efforts to be accepting and informal, they have difficulty avoiding sadomasochistic entanglements with some chronic callers. Even though the younger volunteers tend not to be predisposed to seek professional supervision in learning to manage these difficulties, they are able to use such supervision effectively.
ICE BAG, MODIFIED, FOR USE AFTER TONSILLECTOMY
Authors: Albin M. Painter
Journal: JAMA (1925)

The advantage of this bag is that it keeps the ice over the tonsil area instead of allowing it to gravitate to the central part of the bag as is done in all other throat bags on the market. The illustration shows the shape of the bag in most general use, the name of which I am unable to learn. The central part is closed, keeping ice in the ends, thus necessitating the filling of the bag from both ends. The screw cap is dispensed with because it is not comfortable. Closure is the same as on the ice helmet, only the outer sleeve closes with glove snaps. It is absolutely leak proof and comfortable. It is held in place by tapes tied at the back of the neck. The bag is made by the Tyer Rubber Company, Andover, Mass. <h3>Term Expressing Resistance of Carriers to Superimposed</h3>
Non-specific “non-effects” of vaccination
Authors: Paul E M Fine
Journal: BMJ (2004)

<h3>Introduction</h3> There are 3.9 million people in the UK with diabetes. Sarcopenia, increased frailty and loss of independence are often unappreciated complications of diabetes. Resistance exercise shows promise in reducing these complications in older adult diabetes patients. The aim of this feasibility randomised controlled trial is to (1) characterise the physical function, cardiovascular health and the health and well-being of older adults with mild frailty with/without diabetes treated with insulin, (2) to understand the feasibility and acceptability of a 4-week resistance exercise training programme in improving these parameters for those with diabetes and (3) to test the feasibility of recruiting and randomising the diabetic participant group to a trial of resistance training. <h3>Methods and analysis</h3> Thirty adults aged ≥60 years with insulin-treated diabetes mellitus (type 1 or 2), and 30 without, all with mild frailty (3–4 on the Rockwood Frailty Scale) will be recruited. All will complete blood, cardiovascular and physical function testing. Only the diabetic group will then proceed into the trial itself. They will be randomised 1:1 to a 4-week semisupervised resistance training programme, designed to increase muscle mass and strength, or to usual care, defined as their regular physical activity, for 4 weeks. This group will then repeat testing. Primary outcomes include recruitment rate, attrition rate, intervention fidelity and acceptability, and adherence to the training programme. A subset of participants will be interviewed before and after the training programme to understand experiences of resistance training, impact on health and living with diabetes (where relevant) as they have aged. Analyses will include descriptive statistics and qualitative thematic analysis. <h3>Ethics and dissemination</h3> The North East-Newcastle and North Tyneside 2 Research Ethics Committee (20/NE/0178) approved the study. Outputs will include feasibility data to support funding applications for a future definitive trial, conference and patient and public involvement presentations, and peer-reviewed publications. <h3>Trial registration number</h3> ISRCTN13193281.
672 SCREENING OF OCCULT HBV INFECTION IN BLOOD DONORS IN HONG KONG USING NUCLEIC ACID TESTING
Authors: D.K.H. Wong, C.L. Lai, J. Fung, C.K. Lee, C.K. Lin, I.F.N. Hung, D. But, A. Hsu, P. Chan, T.K. Cheung, F. Fung, J.C.H. Yuen, J. Young, V. Ngai, M.F. Yuen
Journal: Journal of Hepatology (2008)
Clinical Features of Fluid Retention Complicating Treatment with Guanethidine
Authors: A. J. SMITH
Journal: Circulation (1965)

Forty-four (32.8 per cent) of 134 patients [see figure in the PDF file] treated continuously with guanethidine for a period of at least 12 months developed recognizable fluid retention. Previous edema may be a predisposing factor and fluid retention occurred more commonly in women. Neither of these factors offers a complete explanation of this side effect. No evidence has been found to suggest that fluid retention occurs preferentially in patients with renal or cardiac insufficiency. The findings are compatible with a universal fluidretaining influence of guanethidine presenting as a graded phenomenon.
<i>Chlamydia trachomatis</i>Proctitis
Authors: Thomas C. Quinn, Steven E. Goodell, Emmanuel Mkrtichian, Michael D. Schuffler, San Pin Wang, Walter E. Stamm, King K. Holmes
Journal: New England Journal of Medicine (1981)

One hundreds seventy-one homosexual men, 96 of whom had symptoms suggestive of proctitis and 75 of whom had no such symptoms, were consecutively enrolled in a study of the prevalence, clinical spectrum, and histopathology of Chlamydia trachomatis rectal infections. C. trachomatis was isolated from the rectums of 14 men. Three of the isolates, which had lymphogranuloma venereum (LGV) immunotypes, were recovered from three men with symptoms and signs of severe proctitis, two of whom had granulomatous inflammation that was observed at rectal biopsy and was initially suggestive of Crohn's disease. Eleven isolates, which had non-LGV immunotypes, were obtained from eight symptomatic and three asymptomatic men, all of whom had fecal leukocytes and mild abnormalities of the mucosa present at sigmoidoscopy, usually with mild nongranulomatous inflammatory changes that were seen on rectal biopsy. These observations suggest that the presence of LGV immunotypes of C. trachomatis in the rectum is associated with severe acute proctitis that mimics Crohn's disease of the rectum, whereas the non-LGV immunotypes are associated with a mild proctitis with or without symptoms.
The parathyroid is a target organ for FGF23 in rats
Authors: Iddo Z. Ben-Dov, Hillel Galitzer, Vardit Lavi-Moshayoff, Regina Goetz, Makoto Kuro-o, Moosa Mohammadi, Roy Sirkis, Tally Naveh-Many, Justin Silver
Journal: Journal of Clinical Investigation (2007)

Phosphate homeostasis is maintained by a counterbalance between efflux from the kidney and influx from intestine and bone. FGF23 is a bone-derived phosphaturic hormone that acts on the kidney to increase phosphate excretion and suppress biosynthesis of vitamin D. FGF23 signals with highest efficacy through several FGF receptors (FGFRs) bound by the transmembrane protein Klotho as a coreceptor. Since most tissues express FGFR, expression of Klotho determines FGF23 target organs. Here we identify the parathyroid as a target organ for FGF23 in rats. We show that the parathyroid gland expressed Klotho and 2 FGFRs. The administration of recombinant FGF23 led to an increase in parathyroid Klotho levels. In addition, FGF23 activated the MAPK pathway in the parathyroid through ERK1/2 phosphorylation and increased early growth response 1 mRNA levels. Using both rats and in vitro rat parathyroid cultures, we show that FGF23 suppressed both parathyroid hormone (PTH) secretion and PTH gene expression. The FGF23-induced decrease in PTH secretion was prevented by a MAPK inhibitor. These data indicate that FGF23 acts directly on the parathyroid through the MAPK pathway to decrease serum PTH. This bone-parathyroid endocrine axis adds a new dimension to the understanding of mineral homeostasis.
Tetracycline and Acne Vulgaris: A Clinical and Laboratory Investigation
Authors: W. J. Cunliffe, R. A. Forster, N. D. Greenwood, C. Hetherington, K. T. Holland, R. L. Holmes, S. Khan, C. D. Roberts, M. Williams, B. Williamson
Journal: BMJ (1973)

A satisfactory clinical response to long-term oral tetracycline treatment was associated with a mean serum tetracycline of 1.98 mug/ml. The surface lipid showed an increased triglyceride, decreased free fatty acids, and decreased cholesterol, and the amount of keratin within the pilosebaceous duct was reduced. At this dose level there was no quantitative decrease in the bacterial flora though there was a decrease in the fatty acids. We believe that the latter was due to a direct inhibition by tetracycline on extracellular lipases.
Enhanced angiogenesis mediated by vascular endothelial growth factor plasmid-loaded thermo-responsive amphiphilic polymer in a rat myocardial infarction model
Authors: Jin Sook Kwon, In Kyu Park, Ae Shin Cho, Sun Mi Shin, Moon Hwa Hong, Seo Yeon Jeong, Yong Sook Kim, Jung-Joon Min, Myung Ho Jeong, Won Jong Kim, Seongbong Jo, Suzie H. Pun, Jeong Gwan Cho, Jong Chun Park, Jung Chaee Kang, Youngkeun Ahn
Journal: Journal of Controlled Release (2009)
Clinical Features Associated with Mutations in the Chromosome 1 Open-Angle Glaucoma Gene (<i>GLC1A</i>)
Authors: Wallace L.M. Alward, John H. Fingert, Michael A. Coote, A. Tim Johnson, S. Fabian Lerner, Denise Junqua, Fiona J. Durcan, Paul J. McCartney, David A. Mackey, Val C. Sheffield, Edwin M. Stone
Journal: New England Journal of Medicine (1998)

A substantial proportion of cases of glaucoma have a genetic basis. Mutations causing glaucoma have been identified in the chromosome 1 open-angle glaucoma gene (GLC1A), which encodes a 57-kd protein known as myocilin. The normal role of this protein and the mechanism by which mutations cause glaucoma are not known.
Lack of Association Between Serum Immunoreactivity and <i>Chlamydia pneumoniae</i> Detection in the Human Aortic Wall
Authors: Massimo Porqueddu, Rita Spirito, Alessandro Parolari, Marco Zanobini, Giulio Pompilio, Gianluca Polvani, Francesco Alamanni, Davide Stangalini, Elena Tremoli, Paolo Biglioli
Journal: Circulation (2002)

Only a few studies have focused the attention on the relation between elevated anti-Chlamydia pneumoniae (CP) antibodies and the detection of CP in the arterial wall. The aim of our study is thus to investigate the relationship between immune response to CP and detection of CP in the aortic walls of patients with abdominal aortic aneurysm.A specimen of aortic wall was obtained from 102 consecutive patients who underwent abdominal aneurysm repair. The possible presence of CP was studied by polymerase chain reaction and confirmed by nonradioactive DNA hybridization. Antibody response to CP was studied (IgG, IgA titers). We found 33 patients (32.4%) with CP DNA+. No correlation between CP DNA detection and antibody titers was found (IgG P=0.52, IgA P=0.66). High correlation between IgG and IgA titer was observed (P<0.01). Endovascular presence of CP and antibody titers was not related to the age of the patient.CP antibody titers are not associated with the presence of CP in the aortic wall of patients with abdominal aortic aneurysm.
Simultaneous demonstration of the Philadelphia chromosome in T, B, and myeloid cells
Authors: Archie A. Mackinney, Steven S. Clark, Wayne Borcherding, Marco Fizzotti, Richard Hong
Journal: American Journal of Hematology (1993)

Abstract A patient presented with lymphoblastic lymphoma in lymph‐nodes and chronic myeloge‐nous leukemia (CML) in marrow and peripheral blood. All marrow and unstimulated peripheral blood cells contained the Philadelphia chromosome{t(9:22)}. Lymphoma cells were analyzed by flow cytometry and were identified as T cells (CD2+CD5+CD7+CD34+). All fresh lymphoma cells contained the t(9:22) translocation. Cultures of purified peripheral blood T and B cells and specifically stimulated NK cells revealed that 59% of the B cells, 10% of the NK cells, and none of the normal T cells contained the translocation. The lack of translocation in normal peripheral T cells is attributed to their long lifespan. No rearrangement of immunoglobulin or T cell receptor beta or gamma genes was found in either the leukemia or lymphoma cells. Analysis of the DNA from cryopreserved lymphoma biopsy showed clonal rearrangement within the common breakpoint cluster region of the bcr gene identical to the bcr rearrangement in DNA from leukemia blood cells. The data support the concept that T and B cells originate in the patient's totipotent stem cell from which the CML is also derived. © 1993 Wiley‐Liss, Inc.
Recurrent pericarditis: a rare complication of allergen immunotherapy
Authors: S. Quirce, M. Fernandez Rivas, E. Losada, B. de la Hoz, J. Fraj, E. Alvarez Cuesta
Journal: Allergy (1992)

We report on a 29‐year‐old woman suffering from hay fever due to grass and olive tree pollens. She developed recurrent pericarditis during her first course of immunotherapy with an alum‐adsorbed pollen extract. A causal relationship was established between the allergen injections and the acute pericarditis episodes on two consecutive occasions, which presented with blood eosinophilia. Blood cultures and serological tests for microorganisms were negative. There were no signs of autoimmune disease or systemic vasculitis. To the best of our knowledge, allergen immunotherapy‐induced pericarditis has not been previously reported.
Dukes's patient
Authors: Andrew Crowther
Journal: BMJ (2005)

rheumatoid arthritis has improved considerably in recent years, and joint replacement surgery, as with other joints, provides relief of pain for end stage disease. ConclusionsShoulder pain is a common and important musculoskeletal problem.Management should be multidisciplinary and include self help advice, analgesics, relative rest, and access to physiotherapy.Steroid injections have a marginal short term effect on pain.Poorer prognosis is associated with increasing age, female sex, severe or recurrent symptoms at presentation, and associated neck pain.Mild trauma or overuse before onset of pain, early presentation, and acute onset have a more favourable prognosis. 3 25w12 No evidence exists to show that early orthopaedic intervention improves the prognosis for most rotator cuff or glenohumeral disorders.Surgery should be considered when conservative measures fail.
THE RELATION OF HYPERGLYCEMIA TO THE RELATIVE BLOOD VOLUME, CHLORINE CONCENTRATION, AND CHLORINE DISTRIBUTION IN THE BLOOD OF DOGS
Authors: Lee Foshay
Journal: The Journal of Experimental Medicine (1925)

1. In normal dogs experimental hyperglycemia causes a prompt dilution of the circulating blood. This is evidenced by the increase in the relative volume of serum and the reduction of the erythrocyte counts. If the hyperglycemia is large, the viscosity of the blood is visibly diminished. 2. As the hyperglycemia increases there occurs a reduction of the serum chlorine concentration and an increase in the concentration of corpuscular chlorine. 3. Reduction of an artificial hyperglycemia restores the relative blood volumes to their normal status. The erythrocyte count rises to the normal and the corpuscular chlorine concentration is diminished. If the reduction is a large one, the viscosity of the blood is visibly increased. 4. The same types of conductivity-chloride discrepancy that occur in human blood are found in the blood of dogs. In addition, a third type is described. 5. Hyperglycemia does not cause the same changes in the volume of the average erythrocyte of the dog as it does in the case of human erythrocytes.
A unique case of sarcoidosis: coexistence of sarcoidal granuloma and histological changes consistent with dermatomyositis
Authors: A. Ito, T. Kazama, M. Ito
Journal: British Journal of Dermatology (2003)

Journal Article A unique case of sarcoidosis: coexistence of sarcoidal granuloma and histological changes consistent with dermatomyositis Get access A. Ito, A. Ito Department of Dermatology, Niigata University School of Medicine, 1‐757 Asahimachi‐dori, Niigata 951‐8510, Japan E‐mail: akko@med.niigata‐u.ac.jp Search for other works by this author on: Oxford Academic Google Scholar T. Kazama, T. Kazama Department of Dermatology, Niigata University School of Medicine, 1‐757 Asahimachi‐dori, Niigata 951‐8510, Japan E‐mail: akko@med.niigata‐u.ac.jp Search for other works by this author on: Oxford Academic Google Scholar M. Ito M. Ito Department of Dermatology, Niigata University School of Medicine, 1‐757 Asahimachi‐dori, Niigata 951‐8510, Japan E‐mail: akko@med.niigata‐u.ac.jp Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 149, Issue 2, 1 August 2003, Pages 430–432, https://doi.org/10.1046/j.1365-2133.2003.05448.x Published: 01 August 2003
Corticosteroid or corticotrophin therapy in Crohn's disease (regional enteritis)
Authors: W. T. Cooke, J. F. Fielding
Journal: Gut (1970)

Amongst 300 patients with Crohn's disease followed between 1944 and 1968, corticosteroids or corticotrophin was given to 124 patients, to 87 of them for more than 12 months. In the short-term assessment of 89 of these patients, 76% improved clinically within six months, but within 12 months 29% of these had relapsed. In the long term, the risk of operation each year for the patients treated with steroids was twice that of those not treated. There was a significantly increased mortality rate in the patients treated with steroids which in part was due to complications induced by this therapy for which no evidence of long-term benefit emerged from this study.
Abstract 2811: GPC1 promotes tumor growth and angiogenesis in a KrasG12D- Driven mouse model of pancreatic cancer
Authors: Chery A. Whipple, Murray Korc
Journal: Cancer Research (2011)

Abstract Pancreatic ductal adenocarcinoma (PDAC) is an extremely aggressive malignancy that is highly therapy-resistant and is the fourth leading cause of cancer-related deaths. The poor prognosis is due, in part, to late diagnosis in conjunction with a high frequency of activating Kras mutations, a loss of the tumor suppressor genes p16INK4A/p14ARF, as well as an over-abundance of heparin-binding growth factors (HBGFs) and their co-receptors. Glypican-1 (GPC1), a co-receptor required for efficient signaling by heparin-binding growth factors, is overexpressed in PDAC and plays a critical role in cell growth, metastasis, and angiogenesis of human and mouse cancer cells. While it is known that the loss of GPC1 results in decreased tumor growth and metastasis in orthotopic mouse models, GPC1's role in pancreatic tumor initiation, development, and progression is unknown. Accordingly, we generated a GPC1 null mouse that combines pancreas-specific Cre-mediated activation of oncogenic Kras (KrasG12D) and deletion of a conditional Ink4a/Arf tumor suppressor allele. Loss of GPC1 resulted in attenuated pancreatic tumor growth and invasiveness, as well as decreased angiogenesis, cancer cell proliferation, and mitogen activated protein kinase (MAPK) activation. These differences were first observed in 30 day old mice and were still highly significant in 65 day old mice. Moreover, pancreatic cancer cells isolated from the tumors of GPC1 null mice were not as invasive in response to fibroblast growth factor 2 (FGF2) as cancer cells isolated from wild-type mice. These data demonstrate in a genetic mouse model of PDAC that GPC1 does not contribute to pancreatic cancer initiation, but that even in the presence of two highly prevalent molecular alterations (oncogenic Kras and loss of p16) endogenous GPC1 contributes to PDAC progression by facilitating tumor growth, angiogenesis, and invasion. Our findings support the concept that GPC1 may be a therapeutic target in PDAC. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 102nd Annual Meeting of the American Association for Cancer Research; 2011 Apr 2-6; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2011;71(8 Suppl):Abstract nr 2811. doi:10.1158/1538-7445.AM2011-2811
Housing, health, and illness
Authors: D. S Pickup, S P Mookerjee
Journal: BMJ (1978)

myocardial infarction so that any arrhythmia that developed could be treated promptly.However, there is evidence that hospital care may actually cause some of the arrhythmias that then have to be treated.More than 20 years ago Dr Klaus Jarvinen' observed that a disproportionate number of patients dying in hospital after acute myocardial infarction did so during or shortly after ward rounds.That interaction with hospitals and staff can significantly affect a patient's heart rate and rhythm is also well documented.2Although no one would suggest that there is no place for specialised coronary care units it is tempting to speculate that they have to be so well equipped and expertly staffed to compensate for the arrhythmias precipitated by the fear and isolation experienced by a patient in hospital.A study comparing the incidence of arrhythmias after myocardial infarction at home and in hospital would be most interesting.
Past and future, human and nonhuman, semantic/procedural and episodic
Authors: James R. Hurford, Molly Flaherty, Giorgis Argyropoulos
Journal: Behavioral and Brain Sciences (2007)

Abstract The overlap of representations of past and future is not a completely new idea. Suddendorf &amp; Corballis (S&amp;C) usefully discuss the problems of testing the existence of such representations. Our taxonomy of memory differs from theirs, emphasizing the late evolutionary emergence of notions of time in memory.
Anaesthesia on board charity ship staves off burnout
Authors: K. D Thomson
Journal: BMJ (1995)

EDITOR,--Bryan Christie reports that the Princess Royal advocates that NHS staff should work in the developing world.1 I am a consultant anaesthetist who since 1991 has spent three weeks each year anaesthetising patients for ophthalmic and maxillofacial surgery on board the ship Anastasis off west Africa. My enlightened employers permit me to take this extra time away as …
Cochrane reviewers' response to Alper and colleagues' analysis of thrombolysis in acute ischaemic stroke
Authors: J. Wardlaw, E. Berge
Journal: BMJ (2015)

Alper and colleagues question the validity of the Cochrane review of thrombolytic treatment in stroke and our conclusion that treatment improves outcome if given up to 4.5 hours after stroke.1 They find the review confusing, but fail to acknowledge that the review includes 25 years’ worth of data from trials of several different thrombolytic drugs, not just alteplase. 

The review clearly distinguishes between “thrombolytic therapy” meaning all drugs considered …
Mechanisms of Protein Seeding in Neurodegenerative Diseases
Authors: Lary C. Walker, Marc I. Diamond, Karen E. Duff, Bradley T. Hyman
Journal: JAMA Neurology (2012)

Most age-associated neurodegenerative diseases involve the aggregation of specific proteins within the nervous system. In Alzheimer disease, the insidious pathogenic process begins many years before the symptoms emerge, and the lesions that characterize the disease—senile plaques and neurofibrillary tangles—ramify systematically through the brain. We review evidence that the β-amyloid and tau proteins, which aggregate to form senile plaques and neurofibrillary tangles, respectively, are induced to misfold and self-assemble by a process of templated conformational change that amplifies a toxic species. Recent data also indicate that the spread of these lesions from one site to another is mediated by the cellular uptake, transport, and release of endogenous seeds formed by the cognate proteins. This simple pathogenic principle suggests that the formation, trafficking, and metabolism of pathogenic protein seeds are promising therapeutic targets for Alzheimer disease and other neurodegenerative disorders.