COMBINED HYPERSENSITIVITY REACTION TO SODIUM PARA-AMINOSALICYLATE AND ASSOCIATED ANTIBACTERIAL DRUG CONCURRENTLY ADMINISTERED
Authors: A A COHEN, S H LAWRENCE
Journal: Annals of Internal Medicine (1957)

Article1 May 1957COMBINED HYPERSENSITIVITY REACTION TO SODIUM PARA-AMINOSALICYLATE AND ASSOCIATED ANTIBACTERIAL DRUG CONCURRENTLY ADMINISTEREDAARON A. COHEN, M.D., S. H. LAWRENCE, M.D.AARON A. COHEN, M.D.Search for more papers by this author, S. H. LAWRENCE, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-46-5-893 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptIn the present-day management of tuberculosis, treatment with various combinations of streptomycin, isoniazid and para-aminosalicylic acid salts,† is standard practice. As is well known, each of these drugs may produce hypersensitivity reactions. It is not well known, however, that an allergic response may occur during treatment with a combination of two of these agents which is triggered by both. Two such unusual cases occurred recently at this institution, manifesting a peculiar reaction previously attributed to PAS alone. A third case presented the same uncommon response while on combined therapy, but was subsequently considered to be sensitive only to PAS.A...Bibliography1. Moore JE: Modern treatment of syphilis, 2nd Ed., 1941, Charles C. Thomas, Springfield, Ill. Google Scholar2. StokesBeermanIngraham JHHNR: Modern clinical syphilology, 3rd Ed., 1944, W. B. Saunders Co., Philadelphia, Pa. Google Scholar3. WarringHowlett FCKS: Allergic reactions to para-aminosalicylic acid, Am. Rev. Tuberc. 65: 235, 1952. MedlineGoogle Scholar4. JefferyBorrieMacDonald BPN: Acquired hypersensitivity to sodium PAS, streptomycin, and penicillin, Brit. M. J. 2: 647, 1952. CrossrefMedlineGoogle Scholar5. Crofton JW: Desensitization to streptomycin and PAS, Brit. M. J. 2: 1014, 1953. CrossrefMedlineGoogle Scholar6. 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PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byDrug-Induced FeverTuberculosis and the blood — A special relationship?Cytologic and Histologic Aspects of Toxically Induced Liver ReactionsTHE HISTOPATHOLOGY OF DRUG-INDUCED LIVER DISEASEHypersensitivity to para-aminosalicylic acidHepatitis Due to p-Aminosalicylic Acid HypersensitivityIcterus and Febrile Reactions in Response to Isonicotinic Acid Hydrazine 1 May 1957Volume 46, Issue 5 Page: 893-906 Keywords Antigens Drugs Hypersensitivity Isoniazid Neutropenia Periodic acid Schiff Potassium Salts Sodium Streptomycin ePublished: 1 December 2008 Issue Published: 1 May 1957 PDF downloadLoading ...