Hemolytic Anemia Due to a Defective Teflon Aortic Valve Prosthesis
Authors: EDWARD D. VINER
Journal: Annals of Internal Medicine (1965)

Case Studies1 August 1965Hemolytic Anemia Due to a Defective Teflon Aortic Valve ProsthesisEDWARD D. VINER, M.D., JOHN W. FROST, M.D., F.A.C.P.EDWARD D. VINER, M.D., JOHN W. FROST, M.D., F.A.C.P.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-63-2-295 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptAs the techniques of cardiac surgery have been refined, with the use of various new heart-lung machines and intracardiac prostheses and with the ultimate possibility of a successful artificial heart, increasing attention has been focused on the effect of these devices on the circulating erythrocytes. Transient anemia, one of the manifestations of the "postperfusion" syndrome described by Kreel and associates (1) and Wheeler, Turner, and Scannell (2), is now frequently recognized. After several months, these patients have no evidence of a residual hemolytic process.In sharp contrast are seven reported cases of severe, prolonged intravascular hemolysis after the repair with...References1. KREELZAROFFCANTERKRASNABARNOFSKY ILIJWIID: A syndrome following total body perfusion. Surg. Gynec. Obstet. 111: 317, 1960. MedlineGoogle Scholar2. WHEELERTURNERSCANNELL EOJDJG: Fever, splenomegaly and atypical lymphocytes—a syndrome observed after cardiac surgery utilizing a pump oxygenator. New Eng. J. Med. 266: 454, 1962. CrossrefMedlineGoogle Scholar3. SAYEDDACIEHANDLEYCLELAND HMJVSMWP: Hemolytic anemia of mechanical origin after open heart surgery. Thorax 16: 356, 1961. CrossrefMedlineGoogle Scholar4. VERDONFORRESTERCROSBY TARHWH: Hemolytic anemia after open-heart repair of ostium-primum defects. New Eng. J. Med. 269: 444, 1963. CrossrefMedlineGoogle Scholar5. SIGLERFORMANZINKHAMNEILL ATENWHCA: Severe intravascular hemolysis following surgical repair of endocardial cushion defects. Amer. J. Med. 35: 467, 1963. CrossrefMedlineGoogle Scholar6. SANYLPOLESKYHUMEBROWN SKHFMMJ: Spontaneous partial remission of postoperative hemolytic anemia in a case with ostium primum defect. Circulation 30: 803, 1964. CrossrefMedlineGoogle Scholar7. REEDDUNN WAM: Fatal hemolysis following ball valve replacement of the aortic valve. J. Thorac. Cardiov. Surg. 48: 436, 1964. CrossrefMedlineGoogle Scholar8. BRODEURSUTHERLANDKOLERKIMSEYGRISWOLD MTDWRDJAHE: Red cell survival in patients with aortic valvular disease and ball valve prostheses. Abstracts of the Thirty-seventh Scientific Session of the American Heart Association. Circulation 30 (Supplement 3): 55, 1964. MedlineGoogle Scholar9. STEVENSONBAKER TDHJ: Hemolytic anemia following insertion of Starr-Edwards valve prosthesis. Lancet 2: 982, 1964. CrossrefMedlineGoogle Scholar10. MARSH GW: Intravascular hemolytic anemia after aortic volve replacement. Ibid., p. 986. Google Scholar11. PIROFSKYSUTHERLANDSTARRGRISWOLD BDWAHE: Hemolytic anemia complicating aortic-valve surgery: an autoimmune syndrome. New Eng. J. Med. 272: 235, 1964. CrossrefGoogle Scholar12. BRAINDACIEHOURIHANE MCJVDO: Microangiopathic hemolytic anemia: the possible role of vascular lesions in pathogenesis. Brit. J. Haemat. 8: 358, 1962. CrossrefMedlineGoogle Scholar13. LOCKDORMANDY SPKM: Red cell fragmentation syndrome—a condition of multiple etiology? Lancet 1: 1020, 1961. CrossrefMedlineGoogle Scholar14. FERBERSKIRKLIN EWJW: Studies of hemolysis with a plastic sheet bubble oxygenator. J. Thorac. Surg. 36: 23, 1958. CrossrefMedlineGoogle Scholar15. HIROSEGOLDSTEINBAILEY TRCP: Hemolysis of blood due to exposure to different types of plastic tubing and the influence of ethylene-oxide sterilization. J. Thorac. Cardiov Surg. 45: 245, 1963. CrossrefMedlineGoogle Scholar16. KEITHGINNWILLIAMSCAMPBELL HBEGRGS: Massive hemolysis in extracorporeal circulation. J. Thorac. Cardiov. Surg. 41: 404, 1961. CrossrefMedlineGoogle Scholar17. KUSSEROWKENDALL BKLW: In vitro changes in the corpuscular elements of blood flowing in tubular conduits. Trans. Amer. Soc. Artif. Intern. Organs 9: 262, 1963. MedlineGoogle Scholar18. NUNNBARILAATWOOD DBTGEL: Hemolysis studies on three types of artificial heart pump valves. Ibid., p. 253. Google Scholar19. OSBORNCOHNHAITRUSSISALELHARKINSGERBODE JJKMMAGF: Hemolysis during perfusion. Sources and means of reduction. J. Thorac. Cardiov. Surg. 43: 459, 1962. CrossrefMedlineGoogle Scholar20. PO-TUN FOKSCHUBOTHE FH: Studies on various factors influencing mechanical hemolysis of human erythrocytes. Brit. J. Haemat. 6: 355, 1960. CrossrefMedlineGoogle Scholar21. STEWARTSTURRIDGE JWMF: Hemolysis caused by tubing in extracorporeal circulation. Lancet 1: 340, 1959. CrossrefMedlineGoogle Scholar22. WESOLOWSKIFRIESSAWYER SCCPN: The production and significance of turbulence in hemic systems. Trans. Amer. Soc. Artif. Organs 8: 11, 1962. CrossrefMedlineGoogle Scholar23. STOHLMANSARNOFFCASENESS ESJRBAT: Hemolytic syndrome following the insertion of a lucite ball valve prosthesis intro the cardiovascular system. Circulation 13: 586, 1956. CrossrefMedlineGoogle Scholar24. DECESARERATHHUFNAGEL WCC: Hemolytic anemia of mechanical origin with aortic-valve prosthesis. New Eng. J. Med. 272: 1045, 1965. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Philadelphia, PennsylvaniaFrom the Hematology Section of the Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pa.Dr. Viner is a Daland Fellow for Research in Clinical Medicine of the American Philosophical Society, and Trainee in Hematology under training grant T1-Am-5228 of the U.S. Public Health Service.Requests for reprints should be addressed to Edward D. Viner, M.D., Pennsylvania Hospital, 8th and Delancy Sts., Philadelphia, Pa. 19107. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByInvestigation of poikilocytic normochromic normocytic anemiaFactors influencing hemolysis in valve prosthesisIntravascular Hemolysis and Consumption Coagulop- Athy in Defective Aortic Valve Prosthesis. Transient, Beneficial Effect of Heparin and Recovery Following Successful Replacement of ValveSuccessful replacement of aortic and mitral valves with ball valve prostheses in a patient with rheumatic heart disease and SC hemoglobinopathyHemolysis associated with plastics?A histopathologic study with polyurethaneHemolysis after heterograft and prosthetic valve replacementIntravascular hemolysis associated with coarctation of the aortaMECHANICAL HEMOLYSIS IN AORTIC VALVULAR DISEASE AND AORTIC BALL-VALVE PROSTHESISPROSTHETIC HEART VALVE REPLACEMENTMechanical hemolysis in patients with valvular heart disease and valve prosthesisChronic haemolysis occurring in patients following cardiac surgery.Serum Lactate Dehydrogenase Elevation in Ambulatory Cardiac PatientsHerzklappenfehler und HämolyseAortic Valve Disease and Hemolytic AnemiaDAVID W. WESTRING, M.D.Severe Mechanical Hemolytic Anemia Due to Valvular Heart Disease Without ProsthesisSAUL ZIPEROVICH, M.D., H. W. PALEY, M.D.LEIOMYOSARCOMA OF THE INFERIOR VENA CAVARenal Siderosis Morphology, Etiology, Pathogenesis and Differential Diagnosis 1 August 1965Volume 63, Issue 2Page: 295-301KeywordsAnemiaAortic valveCardiac surgeryCorticosteroid therapyHematology and oncologyHemolytic anemiaMedical servicesThoracic surgery Issue Published: 1 August 1965 PDF DownloadLoading ...