tbuckley/cabot-search huggingface dataset:
Excimer laser therapy (308 nm) for mycosis fungoides palmaris et plantaris: a skin-directed and anatomically feasible treatment
Authors: S.P. Jin, Y.K. Jeon, K.H. Cho, J.H. Chung
Journal: British Journal of Dermatology (2010)

British Journal of DermatologyVolume 163, Issue 3 p. 651-653 Excimer laser therapy (308 nm) for mycosis fungoides palmaris et plantaris: a skin-directed and anatomically feasible treatment S.P. Jin, S.P. Jin Departments of Dermatology andSearch for more papers by this authorY.K. Jeon, Y.K. Jeon Pathology, Seoul National University College of Medicine, Seoul National University Hospital, 28 Yeongeon-dong, Jongno-gu, Seoul, South KoreaSearch for more papers by this authorK.H. Cho, K.H. Cho Departments of Dermatology andSearch for more papers by this authorJ.H. Chung, J.H. Chung Departments of Dermatology andSearch for more papers by this author S.P. Jin, S.P. Jin Departments of Dermatology andSearch for more papers by this authorY.K. Jeon, Y.K. Jeon Pathology, Seoul National University College of Medicine, Seoul National University Hospital, 28 Yeongeon-dong, Jongno-gu, Seoul, South KoreaSearch for more papers by this authorK.H. Cho, K.H. Cho Departments of Dermatology andSearch for more papers by this authorJ.H. Chung, J.H. Chung Departments of Dermatology andSearch for more papers by this author First published: 19 August 2010 https://doi.org/10.1111/j.1365-2133.2010.09793.xCitations: 13 Correspondence: Jin Ho Chung E-mail: jhchung@snu.ac.kr Conflicts of interest: none declared. Read the full textAboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinked InRedditWechat Citing Literature Volume163, Issue3September 2010Pages 651-653 RelatedInformation
962. Hypoxia- and Radiation-Activated Cre/loxP Molecular Switch Vectors for Gene Therapy of Solid Tumors
Authors: Olga Greco, Brian Marples, Michael C. Joiner, George D. Wilson, Simon D. Scott
Journal: Molecular Therapy (2004)

Rationale: Tumor hypoxia is a well-known negative prognostic factor for most solid tumors. Nevertheless, hypoxia represents a physiological difference that can be targeted for selective cancer gene therapy. In this study, hypoxia-mediated gene therapy was combined with ionizing radiation. We have shown that gene promoters containing hypoxia regulatory elements (HREs) from the Erythropoietin (Epo) gene and CArG elements from the Early Growth Response 1 (Egr1) gene are activated by hypoxia and/or radiation, ensuring therapeutic gene expression within the tumor mass. To achieve tight and specific gene regulation and produce high and sustained levels of the therapeutic gene herpes simplex virus thymidine kinase (HSVtk), an amplification system based on Cre/loxP recombination was devised. In this 'molecular switch', control of transgene expression is transferred from the inducible promoter to the strong constitutive cytomegalovirus immediate early (CMV IE) promoter.
Framework for teaching and learning informed shared decision making Commentary: Competencies for informed shared decision making Commentary: Proposals based on too many assumptions
Authors: A. Towle, W. Godolphin, T. Greenhalgh, J. Gambrill
Journal: BMJ (1999)

leaflets for patients, Smith emphasised the time it takes to produce clear, unambiguous material that patients will use. 20In addition to following validated quality criteria, writers should take patients' information needs into account and be aware of how people will read what they have written. 21 22This will require involving patients in developing and testing materials. 10Before embarking on this lengthy process, however, a first step is to check if high quality information already exists.
Abstract 14035: Autophagy is Regulated by mir-106b in the Heart
Authors: Christian Kuhn, Lisa Boeck, Susanne Hille, Franziska Dierck, Thomas Eschenhagen, Norbert Frey
Journal: Circulation (2014)

Autophagy is a lysosome-dependent degradation mechanism. In the heart the autophagic flux is induced by starvation and by specific cardiac disorders ranging from pressure overload to myocardial infarction. Recently, microRNAs have been implicated in the control of cardiac autophagy. We found a significant induction of miR-106b in the heart of mice that had been starved for 48h (1.6±0.2-fold, n=11, p&lt;0.05). Moreover, miR-106b is upregulated in cardiac tissue of patients with dilated cardiomyopathy (14.4±4.4-fold, n=3, p&lt;0.05). Interestingly, miR-106b is induced in failing hearts of MLP knockout mice (11.5±2.6 fold, n=5, p&lt;0.05), an established DCM model, as well. Using four different target predictions algorithms (DIANA microT v4.0, miRDB, microRNA.org, TargetScan) we reduced the number of potential targets of miR-106b. Among the genes we found Fyco1. Fyco1 is predominantly expressed in striated muscle and interacts with LC3, a key player in autophagy. We have shown before that Fyco1 is sufficient to induce autophagy in cardiomyocytes. Conversely, Fyco1 deficient mice are protected from increased autophagy by starvation or transverse aortic constriction, but suffer from contractile dysfunction after cardiac stress. Using the mirSVR tool we identified two potential binding sites in the 3’-UTR of murine Fyco1. We inserted each of the predicted binding sites into a luciferase gene based reporter system. Overexpression of miR-106b with either one of the predicted binding sites caused a significant loss of luciferase activity compared to cells that overexpressed a control microRNA or carried a mutated binding site. Interestingly, a fragment that included both target sites reduced the luciferase activity to the same extent (-32%, p&lt;0.001). Overexpression of miR-106b in neonatal rat cardiomyocytes (NRCM) caused a reduction of Fyco1 protein by 72%. Consistently, the overexpression of miR-106b in NRCM prevented the induction of autophagy measured by LC3-II levels after glucose deprivation for 24h. Taken together our data identify a miR-106b/FYCO1-dependent pathway regulating autophagy in the heart. It will be interesting to see whether experimental manipulation of this axis may alter the progression of cardiomyopathy and heart failure.
Abstract P057: Heterogeneity in Blood Pressure and Lipid Trajectories throughout Childhood: Project HeartBeat!
Authors: Norrina B Allen, D. Michael Hallman, Holly Gooding, Laura Rasmussen-Torvik, Christina Shay, Lyn Steffen, Darwin R Labarthe
Journal: Circulation (2014)

Background: Previous studies have examined blood pressure (BP) and lipid changes through childhood and adolescence using population averages. We hypothesized that trajectories for these are heterogeneous, with sub-groups of the population showing different patterns in BP and lipid changes through childhood and adolescence. Methods: This study includes 678 children in Project HeartBeat!. Children were ages 8, 11, or 14 at baseline in 1991 and were examined every 4 mos for up to 4 yrs (mean number of exams, 8). At each exam, lifestyle, anthropometric and laboratory data was collected. Group-based modeling (PROC TRAJ) was used to identify trajectories in systolic BP (SBP), fifth phase diastolic BP (DBP5), total cholesterol (Chol), HDL Chol, LDL Chol and triglycerides as a function of age. The optimal number of race- and sex-adjusted trajectories was determined using the Bayesian Information Criterion and clinical expertise. Results: Among 678 children (49% female; 75% nonblack), 314 were enrolled at age 8, 197 at age 11, and 167 at age 14. Four distinct BP trajectories were identified (figure panels A-B). For SBP the low, low-intermediate, high-intermediate and high groups contained 16.4%, 36.3%, 34.5% and 12.7% of the sample, respectively; for DBP5, they contained 9.5%, 34.2%, 41.0%, and 15.3%. Three trajectories were identified for lipids (panels C-F). The low, intermediate, and high groups included 43.9%, 49.0% and 7.0% of the sample for total Chol, respectively. Corresponding figures were 33.4%, 49.3%, and 17.2% for HDL; 33.5%, 53.9%, and 12.7% for LDL; and 75.3%, 20.3%, and 4.5% for triglycerides, respectively. Girls were less likely (39% vs 61%) to be in the highest SBP groups as compared to the lowest. Blacks were more likely to be in the higher risk trajectories for DBP5 and HDL (p&lt;0.01). Conclusion: Significant heterogeneity exists in BP and lipid trajectories throughout childhood. Finding predictors of the low and high trajectory classes may help target interventions to preserve low risk and manage high risk for future CVD.
Evaluation of the role of MRI in staging rectal cancer within the multidisciplinary team setting
Authors: S. Burton, I. Daniels, G. Brown, M. Stellakis, I. Chau, I. R. Swift, D. Tait, A. Norman, D. Cunningham
Journal: Journal of Clinical Oncology (2004)

3611 Background: The multidisciplinary team (MDT) functions to implement an agreed preoperative treatment strategy for rectal cancer; however, its benefits are unproven. In rectal cancer, presence of tumor at the circumferential margin (R1/R2) is a strong predictor of local recurrence and poor survival with published R1/R2 resection rates of 15–25%. We assessed preoperative MDT discussion of MRI scans and impact of strategy on R1/R2 resection rates in all rectal cancer patients treated between January 1999 and December 2002. Methods: Preoperative MDT discussion of MRI appearances categorized disease as: 1. Favorable: T3 <5mm extramural spread, <4 suspicious nodes, safe potential resection margin –for primary surgery. 2. Locally advanced: T3 >5mm or 4 or more suspicious nodes or tumor involving the potential mesorectal resection margin - for preoperative chemoradiotherapy. 3. Palliative: irresectable metastatic disease on CT scan - for palliative treatment. Local spread and presence of tumor at the resection margins was assessed on histology. Results: There were 301 patients with rectal cancer. Of these, only 34(11%) were classified as palliative. In 67/301 patients, the referring team chose not to undertake MDT discussion of MRI findings prior to primary surgery. The remaining 200 patients had preoperative discussion of MRI. 106/200 showed favorable disease on MRI and underwent primary total mesorectal excision surgery. The remaining 94 patients had locally advanced disease (64/94 had potential resection margin involved by tumour) and received preoperative chemoradiotherapy prior to surgery. The R1/R2 resection rate for those patients undergoing primary surgery for MRI defined favorable disease was 2/106 (2%) compared with 16/67 (24%) in those without MDT discussion of MRI. The overall R1/R2 resection rate for 200 patients with MDT discussion was 17/200 (8.5%), significantly less than the R1/R2 rates in those not undergoing MDT discussion of MRI (p<0.001) and significantly less than published standards. Conclusions: MDT discussion of preoperative MRI with implementation of a selective preoperative strategy significantly reduces R1/R2 resections. No significant financial relationships to disclose.
Pandemic influenza A(H1N1) 2009 breakthrough infections and estimates of vaccine effectiveness in Germany 2009-2010
Authors: O Wichmann, P Stöcker, G Poggensee, D Altmann, D Walter, W Hellenbrand, G Krause, T Eckmanns
Journal: Eurosurveillance (2010)

During the 2009 influenza pandemic, a monovalent AS03-adjuvanted vaccine was almost exclusively used in Germany for immunisation against the 2009 pandemic influenza A(H1N1) virus. One-dose vaccination was recommended for all age groups. We applied the screening method for the rapid assessment of vaccine effectiveness (VE) based on reported data of vaccinated and unvaccinated pandemic influenza cases and vaccination coverage estimates. Preliminary results demonstrate excellent VE in persons aged 14-59 years (96.8%; 95% confidence interval (CI): 95.2-97.9) and moderately high VE in those 60 years or older (83.3%; 95% CI: 71.0-90.5).
von Willebrand factor fibers promote cancer-associated platelet aggregation in malignant melanoma of mice and humans
Authors: Alexander T. Bauer, Jan Suckau, Kathrin Frank, Anna Desch, Lukas Goertz, Andreas H. Wagner, Markus Hecker, Tobias Goerge, Ludmila Umansky, Philipp Beckhove, Jochen Utikal, Christian Gorzelanny, Nancy Diaz-Valdes, Viktor Umansky, Stefan W. Schneider
Journal: Blood (2015)
In HIV Vaccine Efforts, New Strategies and Patience Are Needed in Equal Measure
Authors: Joan Stephenson
Journal: JAMA (2002)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Abstract 12559: Rapid Atrial Pacing Augments Fibrinogen Expression With Activation of IL-6/STAT3 Signaling Pathway in the Rat Liver
Authors: Takanori Yaegashi, Takeshi Kato, Soichiro Usui, Naomi Kanamori, Hiroshi Furusho, Hiroshi Ootsuji, Shinichiro Takashima, Hisayoshi Murai, Shuichi Kaneko, Masayuki Takamura
Journal: Circulation (2014)

Introduction: Atrial fibrillation (AF) activates coagulation system leading to hypercoagulation of the blood. However, it is still unknown whether rapid atrial excitation per se affects gene expression remotely in the liver, the major source of coagulation factors and other prothrombotic molecules. Methods and Results: The AF model was created by rapid atrial pacing at the frequency of 1200 bpm in anesthetized 10-week-old Sprague-Dawley rats. The livers and peripheral blood cells were collected and analyzed after the pacing of 12 hours. Sham-operated rats underwent the identical procedure without electrical stimulation. DNA microarray revealed marked changes in hepatic gene expression after 12 hours atrial pacing. Hierarchical clustering with 13871 filtered genes or genes related to coagulation including fibrinogen, demonstrated clusters for the pacing or sham. The quantitative RT-PCR focused on prothrombotic molecules revealed that rapid atrial pacing significantly augmented the hepatic mRNA expressions of fibrinogen α, β, γ-chain, prothrombin, antithrombin-III, plasminogen, and coagulation factor X. The increase of fibrinogen protein in the liver was also confirmed by Western blotting (Figure A). We further investigated the mechanism of enhanced fibrinogen production and identified increased IL-6 mRNA expression in the peripheral blood cells by rapid atrial pacing (Figure B). IL-6 was also prominent in CD11b positive cells infiltrated in the liver, and possibly promoted STAT3 phosphorylation in the nuclei of hepatocytes (Figure C). Conclusions: The rapid atrial excitation mimicking paroxysmal AF altered the hepatic gene expressions of prothrombotic molecules. Increased fibrinogen expression in the liver was accompanied by activation of IL-6/STAT3 signaling pathway in the peripheral blood and the liver. These findings might imply the cardio-hepatic interaction in AF and provide new insight into the prevention of AF-related thromboembolism.
Abstract 04: Incident Heart Failure and Longitudinal Cognitive Trajectories in the Cardiovascular Health Study
Authors: Christa Schank, Natalie J Blades, Sarwat I Chaudhry, John A Dodson, W T Longstreth, Susan R Heckbert, Bruce M Psaty, Alice M Arnold, Sascha Dublin, Colleen M Sitlani, Julius M Gardin, Stephen M Thielke, Michael Nanna, Rebecca F Gottesman, Anne B Newman, Evan L Thacker
Journal: Circulation (2015)

OBJECTIVE: To determine whether older adults who develop incident heart failure (HF) experience faster cognitive decline than those without HF. METHODS: We analyzed longitudinal cognitive test data from the Cardiovascular Health Study, a community-based study of adults aged 65 years and older. Participants in this analysis did not have HF or history of stroke at baseline and were censored when they experienced incident clinical stroke. Incident HF was identified by self-report of physician-diagnosed HF and confirmed by adjudicated review of inpatient and outpatient medical records and medication use. Outcomes were mean score and rate of decline in mean score on the 100-point Modified Mini-Mental State Examination (3MSE), administered annually up to nine times from 1990 to 1998. A linear mixed effects model was used to model the relationship of cognitive decline with HF and age, adjusted for demographics, health behaviors, and comorbid conditions including hypertension and diabetes. RESULTS: Analyses included 5,211 participants with mean age 74 years at baseline, of whom 545 (10.5%) developed incident HF over a median follow-up of 7.8 years. Mean 3MSE score was lower at the time of HF diagnosis compared with no HF, and declined faster after incident HF compared with no HF. For example, at age 80, covariate-adjusted predicted mean 3MSE score was 88.6 points (95% CI: 88.3, 89.0) in participants without HF, but 87.6 points (95% CI: 87.3, 87.9) in those with newly diagnosed HF. Predicted five-year decline in mean 3MSE score from age 80 to age 85 was 5.9 points (95% CI: 5.7, 6.0) in participants without HF, but 10.0 points (95% CI: 8.6, 11.3) in those diagnosed with incident HF at age 80. Faster decline in 3MSE score after HF diagnosis was seen at all ages studied. The figure shows predicted mean 3MSE score trajectories without HF (solid line) and after HF diagnosed at ages 70, 75, 80, and 85 (dashed lines), with 95% CI shaded. CONCLUSIONS: Older adults diagnosed with incident HF experience faster average cognitive decline than those without HF.
Abstract 718: Systemic delivery of therapeutic siRNA by multifunctional mesoporous silica-based nanocarrier inhibits lung cancer growth and metastasis
Authors: Yijie Chen, Hongchen Gu, Weiliang Xia
Journal: Cancer Research (2014)

Abstract RNAi-based therapy by targeting dysregulated genes has shown great promise in biomedical research but still newer versions of effective and safe delivery systems are required. In this study, we developed a novel siRNA delivery vector based on our magnetic mesoporous silica nanoparticles (M-MSNs) platform. This nanocarrier was constructed by loading siRNAs into the mesopores of M-MSNs, followed by polyethylenimine (PEI) capping, PEGylation and fusogenic peptide KALA modification. The resultant functionalized delivery system exhibited prolonged half-life in bloodstream, enhanced cell membrane translocation and endosomal escapablity, and favorable tissue biocompatibility and biosafety. Systemic application of vascular endothelial growth factor (VEGF) siRNA via this nanocarrier resulted in remarkable tumor suppression, both in subdermal and orthotopic lung cancer models, while tumor metastasis was also significantly reduced, overall leading to improved survival. In addition, the magnetic core of the particles and the functionalized fluorescence markers conveniently enabled in vivo imaging of target tissues. Taken together, this M-MSNs-based siRNA delivery vehicle has shown very favorable applicability for cancer therapy. Citation Format: Yijie Chen, Hongchen Gu, Weiliang Xia. Systemic delivery of therapeutic siRNA by multifunctional mesoporous silica-based nanocarrier inhibits lung cancer growth and metastasis. [abstract]. In: Proceedings of the 105th Annual Meeting of the American Association for Cancer Research; 2014 Apr 5-9; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2014;74(19 Suppl):Abstract nr 718. doi:10.1158/1538-7445.AM2014-718
Expression of HOXC4, HOXC5, and HOXC6 in human lymphoid cell lines, leukemias, and benign and malignant lymphoid tissue
Authors: J Bijl, JW van Oostveen, M Kreike, E Rieger, LM van der Raaij-Helmer, JM Walboomers, G Corte, E Boncinelli, AJ van den Brule, CJ Meijer
Journal: Blood (1996)
Volunteering Overseas Gives Physicians a Measure of Adventure and Altruism
Authors: Mike Mitka
Journal: JAMA (2005)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal