Acquired Inhibitor of Blood Coagulation
Authors: MARTIN L. LEE
Journal: Annals of Internal Medicine (1962)

Case Reports1 June 1962Acquired Inhibitor of Blood CoagulationMARTIN L. LEE, M.D., GIOVANNI RACCUGLIA, M.D.MARTIN L. LEE, M.D.Search for more papers by this author, GIOVANNI RACCUGLIA, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-56-6-946 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptBlood clotting defects which first become manifest in advanced age and in absence of family history should be evaluated not only for quantitative deficiencies but also for qualitative derangements of the normal blood coagulation mechanism. Those disturbances of the coagulation mechanism which are not associated with deficiency are often said to be caused by "circulating anticoagulants" (1, 2). The mechanism of action of these "anticoagulants" has been ascribed to specific chemical (3) or immunological (4) inhibition of certain coagulation factors, to complexing of abnormal proteins with coagulation factors (5), or to "interference" of the extraneous substance with the coagulation reactions...References1. CONLEYHARTMANNMORSE CLRCWI: "Circulating anticoagulants": a technique for their detection and clinical studies. Bull. Johns Hopkins Hosp. 84: 255, 1949. MedlineGoogle Scholar2. HOUGIE C: Circulating anticoagulants. Brit. Med. Bull. 11: 16, 1955. CrossrefMedlineGoogle Scholar3. ALLENJACOBSON JGLO: Hyperheparinemia: cause of hemorrhagic syndrome associated with total body exposure to ionizing radiation. Science 105: 388, 1947. CrossrefMedlineGoogle Scholar4. NUSSEYDAWSON AMDW: Haemophilia-like disease due to an auto-antibody. Brit. Med. J. 5053: 1077, 1957. CrossrefGoogle Scholar5. 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Author, Article, and Disclosure InformationAffiliations: Ann Arbor, MichiganFrom the Thomas Henry Simpson Memorial Institute for Medical Research and the Department of Internal Medicine, University of Michigan Medical Center, Ann Arbor, Michigan.This work was supported by grants from the United States Public Health Service (H-3950) and from the Michigan Heart Association.Requests for reprints should be addressed to Giovanni Raccuglia, M.D., The University of Michigan, The Thomas Henry Simpson Memorial Institute for Medical Research, Ann Arbor, Michigan. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByFactor VIII Inhibitor: Acquired Haemostatic Defect in a Non-Haemophiliac Patient with Rheumatoid ArthritisCirculating anticoagulants to factor VIIIAntibody nature of an AHG (Factor VIII)inhibitorA circulating anticoagulant inhibiting antihaemophilic globulinHemmk�rper-H�mophilie als Schwangerschaftskomplikation 1 June 1962Volume 56, Issue 6Page: 946-956KeywordsAnticoagulantsArthritisBlood coagulationBlood plasmaCoagulation factorsHeartHyperglobulinemiaMedical servicesPlasma proteinsProteins Issue Published: 1 June 1962 PDF DownloadLoading ...