tbuckley/cabot-search huggingface dataset:
Association of Cytidine Deaminase and Xeroderma Pigmentosum Group D Polymorphisms with Response, Toxicity, and Survival in Cisplatin/Gemcitabine-Treated Advanced Non-small Cell Lung Cancer Patients
Authors: Vienna Ludovini, Irene Floriani, Lorenza Pistola, Vincenzo Minotti, Marialuisa Meacci, Rita Chiari, Daniela Garavaglia, Francesca Romana Tofanetti, Antonella Flacco, Annamaria Siggillino, Elisa Baldelli, Maurizio Tonato, Lucio Crinò
Journal: Journal of Thoracic Oncology (2011)
Hypnosis and Acupuncture
Authors: Robert T. London
Journal: JAMA (1974)

<h3>To the Editor.—</h3> Just as hypnosis and biofeedback show excellent results when part of an overall medical plan, so, too, can acupuncture. Dr. Herbert Spiegel of the College of Physicians and Surgeons, Columbia University, has developed a hypnotic induction profile that uses an eye-roll test to determine hypnotizability.<sup>1,2</sup>In this test, the capacity to roll the eyes upward is clinically measured on a scale of 0 to 4. Based on his extensive use of this eye-roll test, Dr. Spiegel estimates that approximately 74% of the population possesses some degree of hypnotizability. That is, they are in the 1 to 4 range. The 3s and 4s make up almost 40% of the population and many of these people are potential candidates for surgical anesthesia by hypnosis. Also, the ability of the "highs" to use suggestion is so great that many chronic organic diseases are better managed in conjunction with hypnosis
One year clinical efficacy and reverse cardiac remodelling in patients with severe mitral regurgitation and reduced ejection fraction after MitraClip<sup>©</sup> implantation
Authors: Sven T. Pleger, Marius Schulz‐Schönhagen, Nicolas Geis, Derliz Mereles, Emmanuel Chorianopoulos, Muliadi Antaredja, Markus Lewening, Hugo A. Katus, Raffi Bekeredjian
Journal: European Journal of Heart Failure (2013)
An important complication of Hancock mitral valve replacement in children.
Authors: L M Kutsche, P Oyer, N Shumway, D Baum
Journal: Circulation (1979)

Nine children ages 2--15 years have undergone mitral valve replacement (MVR) with Hancock porcine heterograft valves for severe mitral insufficiency. The etiology of the mitral valve disease was rheumatic in two patients, and congenital in seven. Porcine valve sizes ranged from 19--31 mm. Follow-up has been from 1.6 to 6.1 years (mean, 4.3 years). All nine children have had marked postoperative improvement, no thromboembolic complications despite no long-term anticoagulations, and no episodes of endocarditis. There have been no early or late deaths. Although six of the nine patients remain asymptomatic, three others developed severe fibrocalcific obstruction of the heterograft, requiring valve re-replacement at 3.5, 3.6, and 4.8 years following the initial valve replacement. This complication has not been previously reported in children. It is a factor that must be considered when deciding on MVR for children and their postoperative management.
Chronic fluoride intoxication.
Authors: T Vischer
Journal: Annals of the Rheumatic Diseases (1969)

HEBERDEN SOCIETYAAPP excretion in as much as they showed a number of features of "malignant rheumatoid arthritis" as described by de Seze (1965).There was no correlation, however, between the abnormally raised AAPP excretion and the rheumatoid factor titre or the erythrocyte sedimen- tation rate.After a 3-year clinical follow-up these same six patients had shown an unrelenting course of their disease, without notable remission, on conventional treatments such as aspirin to tolerance, low dose steroids (<10 mg.prednisone/day), and/or gold salts.This test may thus provide a biochemical basis for the clinical diagnosis of "malignant rheumatoid arthritis" and may turn out to be of prognostic value.
Quality of obstetric care provided for Asian immigrants in Leicestershire.
Authors: M Clarke, D G Clayton
Journal: BMJ (1983)

Between 1976 and 1981 some 939 perinatal deaths occurred to women living in Leicestershire, of which 128 (14%) were to Asian women. The qualifications of the general practitioners, the gestation at which women start antenatal care, and perinatal death were used as structural, process, and outcome measures for evaluating the services provided to Asian immigrants within this population. Perinatal deaths were divided into four groups: congenital malformation, macerated stillbirth, asphyxia in labour, and immaturity. Asian mothers had one and a half times the risk of perinatal mortality when social class, parity, height, legitimacy, and the general practitioner9s qualifications were taken into account. Asian and non-Asian mothers with general practitioners who were not on the obstetric list had more than twice the risk of a perinatal death when a similar adjustment was made. Recommendations include priority allocation of community midwives to practitioners not on the obstetric list, the establishment of postgraduate courses for such doctors, and the continued evaluation of the effect of such proposals on perinatal mortality.
Protection of Myocytes From Hypoxia-Reoxygenation Injury by Nitric Oxide Is Mediated by Modulation of Transforming Growth Factor-β <sub>1</sub>
Authors: J.L. Mehta, H.J. Chen, D.Y. Li
Journal: Circulation (2002)

Background — Reoxygenation injury is a result of several complex events, including release of reactive oxygen species, protein kinase C (PKC) activation, and altered expression of transforming growth factor-β 1 (TGF-β 1 ). Nitric oxide (NO) generally protects tissues from reperfusion injury. Methods and Results — We examined the modulation of TGF-β 1 expression and activity and PKC activation in cultured rat heart myocytes exposed to a brief period of hypoxia-reoxygenation (H-R) by NO donor 3-morpholino-sydnonimine (SIN-1). H-R resulted in an increased expression of total TGF-β 1 (mRNA and protein) but a decrease in the release of active TGF-β 1 . Myocyte PKC-α protein level was not altered by H-R, but its phosphorylation was augmented. Pretreatment of myocytes with SIN-1 diminished myocyte injury quantified as lactate dehydrogenase release. Simultaneously, release of active TGF-β 1 increased and total TGF-β 1 expression decreased (all P &lt;0.05 versus H-R alone). PKC-α phosphorylation increased further in cells treated with SIN-1. The effects of SIN-1 were blocked by the NO scavenger phenyl-tetramethyl-imidazoline-oxyl-oxide as well as by the PKC inhibitor staurosporine. To examine if another NO donor would have a similar effect, cardiomyocytes were treated with nitroglycerin before H-R. With nitroglycerin treatment, similar to SIN-1 treatment, myocyte injury was diminished, TGF-β 1 release increased, and total TGF-β 1 expression decreased. Conclusions — These observations suggest modulation of TGF-β 1 expression as a novel mechanism of salutary effect of NO donors. PKC-α activation may play an important role in the protective effect of NO against H-R injury.
Hiroshima and Ourselves
Authors: Robert Jay Lifton
Journal: JAMA (1985)

WE DO not quite know what to do with Hiroshima. The fact that it stands at all today, and is a thriving city, has to do with the very "small" weapon, compared with those in present nuclear arsenals, dropped on it in 1945. Yet we know that Hiroshima, and Nagasaki too, have much to teach us still. A few vignettes of my own encounters in Hiroshima may suggest the kind of knowledge that city can convey to us. The first lesson I learned in Hiroshima, psychologically speaking, was that no one had studied it. I had been naive enough to believe that some individual or group would have looked at the impact on survivors of a weapon everyone knew to have brought about a tragic turning point in human history. But although there had been considerable work on physical aftereffects, psychological consequences had been ignored. On subsequently reflecting on that
Topical nanocrystalline silver cream suppresses inflammatory cytokines and induces apoptosis of inflammatory cells in a murine model of allergic contact dermatitis
Authors: K.C. Bhol, P.J. Schechter
Journal: British Journal of Dermatology (2005)

Journal Article Topical nanocrystalline silver cream suppresses inflammatory cytokines and induces apoptosis of inflammatory cells in a murine model of allergic contact dermatitis Get access K.C. Bhol, K.C. Bhol NUCRYST Pharmaceuticals Inc., 50 Audubon Road, Suite B, Wakefield, MA 01880, U.S.A Kailash C. Bhol. E‐mail: kbhol@nucryst.com Search for other works by this author on: Oxford Academic Google Scholar P.J. Schechter P.J. Schechter NUCRYST Pharmaceuticals Inc., 50 Audubon Road, Suite B, Wakefield, MA 01880, U.S.A Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 152, Issue 6, 1 June 2005, Pages 1235–1242, https://doi.org/10.1111/j.1365-2133.2005.06575.x Published: 01 June 2005 Article history Accepted: 21 November 2004 Published: 01 June 2005
Examining Homicide's Contribution to Pregnancy-Associated Deaths
Authors: Victoria Frye
Journal: JAMA (2001)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Biomarker surrogates do not accurately predict sputum eosinophil and neutrophil percentages in asthmatic subjects
Authors: Annette T. Hastie, Wendy C. Moore, Huashi Li, Brian M. Rector, Victor E. Ortega, Rodolfo M. Pascual, Stephen P. Peters, Deborah A. Meyers, Eugene R. Bleecker
Journal: Journal of Allergy and Clinical Immunology (2013)
Reviews and Notes: Gastroenterology: The Esophagus
Authors: Richard A. Kozarek
Journal: Annals of Internal Medicine (1996)

Literature of Medicine1 April 1996Reviews and Notes: Gastroenterology: The EsophagusRichard A. Kozarek, MDRichard A. Kozarek, MDVirginia Mason Medical Center, Seattle, WA 98111Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-124-7-199604010-00026 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail 2nd edition. DO Castell. 812 pages. New York: Little, Brown; 1996. $199.95. ISBN 0-316-15842-9. Order phone 800-759-0190.Does this textbook teach you why opossums fail to reflux? No. Is it filled with cocktail party pearls about penguin, ostrich, or giraffe esophagi? No. Then who needs an 800-page tome on the esophagus? Who has time to read what 50 expert esophagologists have to say about a 20-cm transit tube? The wealth of information assembled by Donald Castell is a treasure trove for the interested: clinical and academic gastroenterologists, thoracic and general surgeons, and esophageal physiologists. It is not for the esophageal ... Author, Article, and Disclosure InformationAffiliations: Virginia Mason Medical Center, Seattle, WA 98111 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 April 1996Volume 124, Issue 7Page: 697-698KeywordsEsophagusFoodGastroenterology and hepatologyGastroesophageal reflux diseaseHistologyInfectious diseasesLarynxPharynxSurgeonsSwallowing ePublished: 15 August 2000 Issue Published: 1 April 1996 Copyright & PermissionsCopyright © 1996 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Cumulative effects of soccer heading are not fully known
Authors: R. S Naunheim
Journal: BMJ (2003)

EDITOR—McCrory says in his editorial that heading a soccer ball results in head accelerations of less than 10 g (or less than 1000 rad/s2), whereas the minimum values for the development of sports related concussions are 40-60 g (or 3500-5000 rad/s2),1 with a reference to an article published by our group.

To mix or equate linear acceleration measured in g (1 g = 9.8 m/s2) with angular acceleration …
Glucocorticoid receptors and depression.
Authors: L J Whalley, N Borthwick, D Copolov, H Dick, J E Christie, G Fink
Journal: BMJ (1986)

The number of glucocorticoid receptor sites in lymphocytes was estimated and plasma cortisol concentrations measured in 17 depressed patients, 12 patients with chronic schizophrenia, and 31 healthy control subjects. The number of receptor sites was significantly lower in the depressed patients than in either the controls or the patients with chronic schizophrenia, but there were no differences between the groups in the dissociation constants of the glucocorticoid receptors or the plasma cortisol concentrations. When two control subjects were studied intensively over 28 hours a slight diurnal variation in the number of glucocorticoid receptors was detected. The lower numbers of glucocorticoid receptors in the lymphocytes of depressed patients may explain why such patients, who often have hypercortisolaemia, do not show the clinical features of excess production of cortisol.
Does carbamazepine-induced reduction of plasma haloperidol levels worsen psychotic symptoms?
Authors: G W Arana, D C Goff, H Friedman, M Ornsteen, D J Greenblatt, B Black, R I Shader
Journal: American Journal of Psychiatry (1986)

Seven psychotic patients' plasma haloperidol levels, determined with gas-liquid chromatography, fell a mean of 60% when carbamazepine treatment was instituted. Two patients' levels became undetectable, and their symptoms worsened. Haloperidol level monitoring may be required for patients given both haloperidol and carbamazepine.
The Arsenic-Poisoning Epidemic of 1900
Authors: Henry S. Satterlee
Journal: New England Journal of Medicine (1960)

THE renowned epidemic of arsenic poisoning that occurred among beer drinkers of the Manchester-Salford—Liverpool district of England in the autumn of 1900 remains a historic instance of mass poisoning by mechanisms of special concern today. Two sources were incriminated, the one fairly obvious and easily discovered, and the other an obscure background factor that must have been operative but unrecognized for many years. This underlying factor might indeed have persisted indefinitely if the ingestion of arsenic at relatively asymptomatic levels had not been alarmingly aggravated by access of larger doses of the poison from the more obvious source.As long . . .
Abstract P3-06-14: Increase in the proportion of stage IV breast cancer amongst young women with newly diagnosed breast cancer, report from the National cancer data base, 1998-2009
Authors: K Yao, C Tomasz, C Pesce, D Huo, WJ David, WP David, W Edward
Journal: Cancer Research (2013)

Abstract Background: A recent SEER study showed a significant increase in the incidence of advanced breast cancer in women 25 to 39 years old. We hypothesized a similar trend amongst newly diagnosed breast cancer patients treated at Commission on Cancer Accredited Cancer Centers in the United States and that such increase is greatest among minority young women. Methods: We utilized data from the National Cancer Data Base to determine the proportion of patients &amp;lt;40 years old who were diagnosed with Stage IV disease from 1998-2009. Patient demographics (insurance, race, income) and tumor characteristics (size, node status, grade, estrogen receptor (ER), histology) were included to compare the risk factors associated with advanced disease between younger and older women. Statistical analyses were performed using both univariate and multivariable logistic regressions in SAS 9.3 (SAS Inc., Cary, NC). Results: A total of 1,955,190 women with newly diagnosed breast cancer were included. The proportion of young women (&amp;lt;40 years old) diagnosed with stage IV breast cancer has increased by 58% between 1998 and 2009 (Table 1). This increase in young women was significantly greater than other age groups with Stage IV disease: 40-54 years old (Δ = 9%), 55-69 (Δ = 13%) and &amp;gt;70 years old (Δ = 17%) (all p&amp;lt;0.001). Amongst women with stage IV disease, women &amp;lt;40 years old compared to women ≥40 years old were more likely to be nonwhite (29% vs. 19%, p&amp;lt;.0001), have grade III tumors (70% vs. 57%, p&amp;lt;.0001), have an estrogen receptor (ER) negative tumor (34% vs. 28%, p&amp;lt;.0001), and have a ductal carcinoma (85% vs. 78%, p&amp;lt;.0001). In the multivariable analysis, young women (&amp;lt;40 yr) remained at significantly greater risk of being diagnosed with stage IV disease (OR = 1.19, 95% CI 1.14-1.24, p&amp;lt;.0001) compared to women ≥40 years old after adjusting for income, race/ethnicity and tumor characteristics. While the proportion of women with stage IV disease has increased between 1998 and 2009, the increasing odds was significantly greater among young women (OR = 1.54) as compared to old women (OR = 1.17) in the risk adjusted multivariable models. Table 1. Trend in proportion of women diagnosed with Stage IV disease according to patient age, 1998 and 2009.Age19982009Age &amp;lt;401.973.12Age 40-541.471.61Age 55-691.591.81Age 70+1.802.11 Conclusions: The proportion of women with stage IV disease under 40 years old has increased significantly over the past decade and this trend was not seen in older age groups. Young minority women with ER negative tumors are at greatest risk to be diagnosed at a later stage. Citation Information: Cancer Res 2013;73(24 Suppl): Abstract nr P3-06-14.
Selective constraints on P-element evolution
Authors: D. J. Witherspoon
Journal: Molecular Biology and Evolution (1999)

P elements, like mariners, inhabit eukaryotic genomes and transpose via a DNA intermediate. Mutant and wild-type elements in the same genome should be transposed with equal probability by trans-acting transposase, and so no selection should counteract the accumulation of inactivating mutations in transposase genes. Thus, copies of mariner elements diverge within a host species under no selection (Robertson and Lampe 1995). It is unknown whether or not this pattern holds for P elements, which are unrelated to mariner elements but share the same life history. Publicly available P-element sequences were analyzed for evidence of conservative selection for the function of P-element-encoded proteins. Results were compared to predictions derived from several hypotheses that could explain selection, or the lack of it. P-element protein-coding sequences do evolve under conservative selection but apparently because of more than one selective force. Of the four exons in the P-element transposase, the first three (exons 0, 1, and 2) can be translated alone into a repressor of transposition, while the last (exon 3) is only expressed as part of the full-length transposase and probably serves a transposition-specific role. As full-length P-element copies diverge from each other within a host population, selection maintains exons 0-2 but apparently not exon 3. The selection acting on exons 0-2 may act at the host level for repression of transposition (since host level selection does act on orthologous truncated elements that contain only exons 0-2). Evidence of selection on exon 3 is only found in comparisons of more diverged elements from different species, suggesting that selection for transposition acts primarily at horizontal transfer events. Thus, horizontal transfer events may be the sole source of the selection that is crucial to the maintenance of autonomous P elements in the face of mutation (as suggested by Robertson and Lampe 1995). The predictions derived here suggest a strategy for collecting sequence data that could definitively answer these questions.
Ontological disunity and a realism worth having
Authors: Steve Clarke
Journal: Behavioral and Brain Sciences (2004)

Ross &amp; Spurrett (R&amp;S) appear convinced that the world must have a unified ontological structure. This conviction is difficult to reconcile with a commitment to mainstream realism, which involves allowing that the world may be ontologically disunified. R&amp;S should follow Kitcher by weakening their conception of unification so as to allow for the possibility of ontological disunity.
First Type I Diabetes Prevention Trials
Authors: Andrew A. Skolnick
Journal: JAMA (1997)

AT LEAST 4 clinical trials on 3 continents are now under way to determine whether insulin-dependent diabetes mellitus (IDDM) can be prevented in highrisk patients by stimulating an immunoprotective response. The phase I trials involve the administration of insulin nasally or orally, reported researchers at the Juvenile Diabetes Foundation International's (JDFI) 4th World Conference on Diabetes Research, in Athens, Greece. One of the trials, involving nasally administered insulin, was described by Leonard C. Harrison, MD, director of the Burnet Clinical Research Unit and professorial associate at the University of Melbourne School of Medicine, in Victoria, Australia. More than 30 children and young adults at high risk of developing the disease are enrolled in the double-blind, placebo-controlled, crossover trial in Australia. In the United States, the Diabetes Prevention Trial I, which involves orally administered insulin, is now under way, and there are at least 2 other ongoing trials in Europe and
Absorption of medium and long chain triglycerides: factors influencing their hydrolysis and transport.
Authors: N J Greenberger, J B Rodgers, K J Isselbacher
Journal: Journal of Clinical Investigation (1966)

Recent clinical observations have indicated that triglycerides containing medium chain fatty acids may be useful in decreasing steatorrhea associ- ated with malabsorptive states such as pancreatic insufficiency and extrahepatic biliary tract ob- struction (1, 2).This suggests that significant amounts of medium chain triglycerides may be ab- sorbed under conditions in which there are de- creased intraluminal concentrations of pancreatic enzymes or bile salts.However, few quantitative data are available regarding the intestinal hydroly- sis and the rate of absorption of medium chain tri- glycerides as compared to long chain triglycerides.We have compared the intestinal hydrolysis and absorption of a medium chain triglyceride (tri- octanoin) with those of a long chain triglyceride (tripalmitin) under a variety of experimental con- ditions.These studies were performed with iso- lated intestinal loops in the rat.The data obtained indicate that there are sig- nificant differences in the rates of hydrolysis and absorption of trioctanoin compared to tripalmitin.We also observed that with decreased intraluminal concentrations of bile salts and pancreatic enzymes there was, as expected, decreased absorption of both trioctanoin and tripalmitin.However, under
Unusual Lymphoma Manifestations
Authors: Hikaru Nakajima, Masayuki Oki, Kiyoshi Ando
Journal: Journal of Clinical Oncology (2004)

myocardial infiltration by tumor.A cardiac mass seen on echocardiography or magnetic resonance imaging suggests the diagnosis of cardiac lymphoma, and positive pericardial effusion cytology, endomyocardial biopsy, or direct biopsy via thoracotomy confirms the diagnosis.