tbuckley/cabot-search huggingface dataset:
First clinical experience of contrast enhanced digital mammography (CEDM) for the detection of breast carcinomas.
Authors: C Dromain, C Balleyguier, A Tardivon, F Rimareix, S Delaloge
Journal: Cancer Research (2009)

Abstract Abstract #5001 Purpose: CEDM is a recent development of digital mammography using the intra-venous injection of an iodinated contrast agent in conjunction with a mammography examination. The objective of this paper is to present two techniques developed to perform CEDM examinations, the preliminary clinical experiences and potential clinical applications of this new breast imaging procedure.&amp;#x2028; Material and methods: Between 2005 and 2008, 140 consenting women with suspicious findings on mammography and or ultrasonography underwent CEDM using modified full-field digital mammography systems (GE Healthcare, Chalfont St-Giles, UK). A temporal subtraction sequence with acquisition of high-energy images before and after contrast medium injection was used for the first 20 patients. A dual energy technique with acquisition of a pair of low and high-energy images only after contrast medium injection was used for the other 120 patients.&amp;#x2028; Results: CEDM, either using temporal or dual energy technique, improved the probability of malignancy and the BIRADS assessment compared to conventional mammography alone. The temporal subtraction technique offered the possibility to analyze the kinetic curve of enhancement of breast lesions, similar to breast MRI. Dual energy technique did not provide information about the kinetic of tumor enhancement but allowed the acquisition of multiples views of the same breast or bilateral examination and was less sensitive to patient motion than temporal CEDM. The potential clinical applications are the determination of the extent of disease, the assessment of recurrent disease, the clarification of mammographically equivocal lesions, the detection of occult lesions on standard mammography, particularly in dense breast, and the monitoring of the response to chemotherapy.&amp;#x2028; &amp;#x2028; &amp;#x2028; &amp;#x2028; Conclusion: Initial clinical experience has shown the ability of CEDM to map the distribution of neovasculature induced by cancer using mammography. CEDM should result in a simple way to enhance the detection and the characterization of breast lesions and to provide some prognostic factors of breast carcinomas. Citation Information: Cancer Res 2009;69(2 Suppl):Abstract nr 5001.
The Swan-Ganz Catheter in an Intensive Care Unit
Authors: Francis X. Riedo, Thomas G. Cooney
Journal: Annals of Internal Medicine (1986)

Letters and Corrections1 March 1986The Swan-Ganz Catheter in an Intensive Care UnitFRANCIS X. RIEDO, M.D., THOMAS G. COONEY, M.D.FRANCIS X. RIEDO, M.D.Search for more papers by this author, THOMAS G. COONEY, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-104-3-446_2 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: The recent article on the use of the Swan-Ganz catheter (1) prompted us to review our experience in a medical intensive care unit.Over the course of a 6-month period, one of us supervised the placement of 22 pulmonary artery catheters in 18 patients. Fourteen of those patients (77%) died before leaving the hospital. The mean time to death after placement of the catheter was 5.5 days (range, 0 to 17). The mean age was 59.5 years (range, 37 to 71) for patients who survived and 62.5 years (range, 24 to 87) for those who died. Although...Reference1. ROBIN E. The cult of the Swan-Ganz catheter: overuse and abuse of pulmonary flow catheters. Ann Intern Med. 1985;103:445-9. LinkGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: FRANCIS X. RIEDO, M.D.; THOMAS G. COONEY, M.D.Affiliations: Oregon Health Sciences University Veterans Administration Medical Center Portland, OR 97207 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byThe Swan-Ganz Catheter: A decade of hemodynamic monitoring 1 March 1986Volume 104, Issue 3Page: 446-447KeywordsCathetersIntensive care unitsMedical intensive care unitsPulmonary artery catheters ePublished: 1 December 2008 Issue Published: 1 March 1986 PDF downloadLoading ...
Psychiatry Residents as College Teachers: An Evaluation of a Training for Teaching Program
Authors: ALAN M. LAZERSON
Journal: American Journal of Psychiatry (1973)

Questionnaire evaluation of a recently developed training experience within an overall program designed to prepare psychiatry residents to become better teachers revealed that the project was popular with students, resident teachers, and the college administration. Of the 60 students polled, over 80 percent rated their instructor and their course as above average or better. Eighty-five percent of the responding students felt that they had learned a great deal, and the residents reported that it was also an excellent learning experience for them.
Familial Hypochromic Anaemia with Hyperferricaemia
Authors: A. O. B. Redmond, J. H. Robertson, M. G. Nelson
Journal: BMJ (1963)

MEDIJIyRNAL 89and in the rejection of foreign protein will be required before these features can be explained. SummaryAn attempt was made to demonstrate a relationship between the biochemical, immunological, and clinical features of myeloma.Of the immunological responses tested, the isoagglutinin titre and the antibody response to T.A.B. vaccine were fairly uniformly impaired in the myeloma patients, as compared with controls.No gross depression of response was found on Mantoux-testing, and prolongation of homograft survival could not be proved.Survival of transfused incompatible red cells was markedly increased in two of the myeloma patients.Definite immunological defects were therefore shown to be present in myeloma, but this apparently may occur at any stage in the disease and cannot be correlated with the clinical or biochemical features.The presence of isolated immunological defects at all stages of the disease has been described only in various types of hypogammaglobulinaemia, and it seems likely that in myeloma there is a deficiency of func- tioning globulin, despite the excess of abnormal protein usually present.More knowledge of the factors responsible for the various immune responses tested will be required before the individual features can be explained.We thank Mr. J. Tough and Dr. H.
ON THE DIAGNOSIS OF TUMORS OF THE ANTERIOR MEDIASTINUM.
Authors: JAMES C. WILSON
Journal: JAMA (1884)

Read in the Section on Practice of Medicine and Materia Medica, of Am. Med. Association, May, 1884. It would be difficult to find in the adult human body a region of less intrinsic interest than that space between spaces known to the anatomists as the Anterior Mediastinum. It is narrow and of little depth; at its superior part a small interval is left between the two layers of pleura which bound it; behind the second piece of the sternum, the pleuræ of opposite sides come into contact and it amounts merely to a thin septum; while lower down it is inclined to the left, and widened out into an angular space of some breadth by the recedence of the margin of the left pleura from the sternum (Quain). It is bounded in front by the triangularis sterni muscle, behind by the pericardium, laterally by the reflected borders of the costal
SURFACE MARKERS ON HUMAN B AND T LYMPHOCYTES
Authors: Mikael Jondal, George Klein
Journal: The Journal of Experimental Medicine (1973)

Human peripheral lymphocytes were investigated for receptors binding Epstein-Barr virus (EBV) because of the regular association of this virus with infectious mononucleosis and Burkitt's lymphoma. This was done by a cytoadherence technique where virus-producing cells, displaying fresh viral determinants in their cytoplasmatic membrane, were mixed with lymphocytes. Unfractionated lymphocytes were found to adhere to these cells in contrast to column-purified T lymphocytes. The specificity of the binding was confirmed by blocking experiments that showed that sera containing high titers of antibodies directed against the virus could partially inhibit the adherence in contrast to low-titer sera. It is concluded that B lymphocytes, in contrast to T lymphocytes, have receptors for EBV. In a second line of experiments it was found that established human lymphoblastoid lines that carry the EBV genome had receptors characteristic for B lymphocytes and did not form T-lymphocyte rosettes. In contrast, a line of known T-lymphocyte origin that did not carry the EBV genome had receptors characteristic for T lymphocytes. EBV-transformed simian lymphoblastoid lines had surface markers indicating a B-lymphocyte origin in contrast to HVS-transformed simian lines that lacked surface immunoglobulin but carried receptors for sheep red blood cells.
Empathy and the Literary Imagination
Authors: Thomas S. Artim
Journal: Annals of Internal Medicine (2003)

Letters15 July 2003Empathy and the Literary ImaginationThomas S. Artim, MDThomas S. Artim, MDOrchard Park, NY 14127 (Artim)Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-139-2-200307150-00017-w1 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:I have evidence supporting Dr. Schneiderman's proposition that the literary imagination and empathy are linked (1). As a medical student, I encountered a caring, thoughtful, and astute attending in nephrology who quickly realized, despite my assertions to the contrary, that I had little interest or talent in renal diseases. He quickly guided our discussions to something of mutual interestbooks. Our favorite authors were the same: Conrad, Maugham, Dreiser. We talked vibrantly on rounds for days until I asked him what he was reading now. I was stunned to hear he had time to read only medicine. He ...References1. Schneiderman LJ. Empathy and the literary imagination. Ann Intern Med. 2002;137:627-9. [PMID: 12353969] LinkGoogle Scholar2. The Modern Library. 100 Best Novels of the Twentieth Century. New York: Modern Library; 1998. Google Scholar3. Wright R. Native Son. Chicago: Perennial Classics; 1998. Google Scholar4. Lowry M. Under the Volcano. New York: Plume; 1971. Google Scholar5. Kesey K. One Flew over the Cuckoo's Nest. New York: Penguin; 1976:8. Google Scholar Author, Article, and Disclosure InformationAffiliations: Orchard Park, NY 14127 (Artim) PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoEmpathy and the Literary Imagination Lawrence J. Schneiderman Metrics Cited byPhysician Empathy and Compassion for Inmate-Patients in the Correctional Health Care Setting 15 July 2003Volume 139, Issue 2Page: W-57KeywordsAdolescentsAlcoholsEnzymesEvidence based medicineLiverNephrologyPatient advocacyRenal diseases ePublished: 15 July 2003 Issue Published: 15 July 2003 Copyright & PermissionsCopyright © 2003 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Patients get access to evidence based, online health information
Authors: A. Ferriman
Journal: BMJ (2002)

Patients this week got online access to two evidence based sources of healthcare information: the Cochrane Library, published by Update Software, and Clinical Evidence , published by the BMJ Publishing Group.

The step was due to be announced at the International eHealth Association's annual conference in London this week. Public access to the sources is through the National electronic Library …
Insulin secretory defect plays a major role in the development of diabetes in patients with distal pancreatectomy
Authors: Byung-Wan Lee, Hahn-Wook Kang, Jin-Seok Heo, Seong-Ho Choi, Sang-Yong Kim, Yong-Ki Min, Jae-Hoon Chung, Moon-Kyu Lee, Myung-Shik Lee, Kwang-Won Kim
Journal: Metabolism (2005)
Medical Evaluation of Patients Undergoing Electroconvulsive Therapy
Authors: Anjala V. Tess, Gerald W. Smetana
Journal: New England Journal of Medicine (2009)

In evaluating patients before electroconvulsive therapy (ECT), especially those with conditions such as hypertension, coronary artery disease, and congestive heart failure, the medical consultant should undertake risk stratification, assess management of coexisting conditions, and use strategies to reduce the risk of such post-ECT complications as prolonged blood-pressure elevation, myocardial ischemia, and headache.
Multidetector-Row Computed Tomography in Suspected Pulmonary Embolism
Authors: Arnaud Perrier, Pierre-Marie Roy, Olivier Sanchez, Grégoire Le Gal, Guy Meyer, Anne-Laurence Gourdier, Alain Furber, Marie-Pierre Revel, Nigel Howarth, Alain Davido, Henri Bounameaux
Journal: New England Journal of Medicine (2005)

Single-detector-row computed tomography (CT) has a low sensitivity for pulmonary embolism and must be combined with venous-compression ultrasonography of the lower limbs. We evaluated whether the use of D-dimer measurement and multidetector-row CT, without lower-limb ultrasonography, might safely rule out pulmonary embolism.We included 756 consecutive patients with clinically suspected pulmonary embolism from the emergency departments of three teaching hospitals and managed their cases according to a standardized sequential diagnostic strategy. All patients were followed for three months.Pulmonary embolism was detected in 194 of the 756 patients (26 percent). Among the 82 patients with a high clinical probability of pulmonary embolism, multidetector-row CT showed pulmonary embolism in 78, and 1 patient had proximal deep venous thrombosis and a CT scan that was negative for pulmonary embolism. Of the 674 patients without a high probability of pulmonary embolism, 232 (34 percent) had a negative D-dimer assay and an uneventful follow-up; CT showed pulmonary embolism in 109 patients. CT and ultrasonography were negative in 318 patients, of whom 3 had a definite thromboembolic event and 2 died of possible pulmonary embolism during follow-up (three-month risk of thromboembolism, 1.7 percent; 95 percent confidence interval, 0.7 to 3.9). Two patients had proximal deep venous thrombosis and a negative CT scan (risk, 0.6 percent; 95 percent confidence interval, 0.2 to 2.2). The overall three-month risk of thromboembolism in patients without pulmonary embolism would have been 1.5 percent (95 percent confidence interval, 0.8 to 3.0) if the D-dimer assay and multidetector-row CT had been the only tests used to rule out pulmonary embolism and ultrasonography had not been performed.Our data indicate the potential clinical use of a diagnostic strategy for ruling out pulmonary embolism on the basis of D-dimer testing and multidetector-row CT without lower-limb ultrasonography. A larger outcome study is needed before this approach can be adopted.
Contribution of TIR domain-containing adapter inducing IFN-β-mediated IL-18 release to LPS-induced liver injury in mice
Authors: Michiko Imamura, Hiroko Tsutsui, Koubun Yasuda, Ryosuke Uchiyama, Shizue Yumikura-Futatsugi, Keiko Mitani, Shuhei Hayashi, Shizuo Akira, Shun-ichiro Taniguchi, Nico Van Rooijen, Jurg Tschopp, Tetsuya Yamamoto, Jiro Fujimoto, Kenji Nakanishi
Journal: Journal of Hepatology (2009)
Paclitaxel is incorporated by mesenchymal stromal cells and released in exosomes that inhibit in vitro tumor growth: A new approach for drug delivery
Authors: Luisa Pascucci, Valentina Coccè, Arianna Bonomi, Diletta Ami, Piero Ceccarelli, Emilio Ciusani, Lucia Viganò, Alberta Locatelli, Francesca Sisto, Silvia Maria Doglia, Eugenio Parati, Maria Ester Bernardo, Maurizio Muraca, Giulio Alessandri, Gianpietro Bondiolotti, Augusto Pessina
Journal: Journal of Controlled Release (2014)
Ciné or Vérité?
Authors: Melanie S. Langley
Journal: JAMA (1985)

Nine forty-five. I sighed, glancing at the clock in the emergency room. Typical, I thought, missing the only television program of the fall season that I really had wanted to see. The ironic injustice of it all! The patients who came to our clinic were so different from those I knew in my hometown or in the fancy big-city hospital at my medical school. I thought the documentary about sexually abused children might have helped this naive intern to know these kids when they showed up at our clinic. No such luck tonight, though—best to finish the paperwork now, so I could join the residents downstairs for a sandwich. The triage nurse suddenly grabbed my arm, her face pale. I thought: "This woman makes it possible for the interns to survive the emergency department. If<i>she's</i>upset, it's a code. I know it. A code, and I don't know what
A CASE OF SECONDARY HYPERNEPHROMA OF THE IRIS AND CILIARY BODY.
Authors: BURTON CHANCE
Journal: JAMA (1907)

The man whose history is here detailed came under my observation first in the wards of the Germantown Hospital on Oct. 11, 1905. He had had hemorrhoids, and Dr. C. A. Whiting had operated recently for the removal of them. The house surgeon, Dr. Markle, called my attention to the man because of there being, as he supposed, a growth in the left eye. At the time I made my examination the patient was in what he deemed his usual good health and suffered only from his rectal disease. In the month past he had been annoyed by obscuration of his sight, especially of the left eye, though that eye was neither painful nor tender. I discovered on his body, beneath the skin, over the region of the costocartilaginous junctions on the thorax, several nodular enlargements. These masses were movable and reminded me of the enlargements of the cervical glands
Ischemic Myopathy in Uremic Hyperparathyroidism
Authors: William W. Goodhue
Journal: JAMA (1972)

Proximal, painful myopathy during life and complicating hyperparathyroidism secondary to chronic renal failure has been documented histologically only once previously. This patient's unusual, noninflammatory myopathy, with focal calcium deposits, was due to ischemia caused by luminal stenosis in arterioles with circumferential medial calcification and concentric fibrous intimal proliferation.
Laparoscopic Surgical Treatment of Duodenal Ulcer Disease
Authors: J. Mouiel, N. Katkhouda, L. Iovine
Journal: Endoscopy (1995)

Laparoscopic surgical treatment of duodenal ulcer disease is as safe and efficient as in open surgery and the usefulness of fibrin sealing had been demonstrated in elective cases and in emergency. In elective cases posterior truncal vagotomy and seromyotomy according the Taylor's procedure were used in 62 patients resistant to medical treatment and noncompliant to maintenance drugs. In all cases seromyotomy was closed by an overlap running suture secured by application of fibrin sealant. In emergency cases a laparoscopic approach was performed for perforated ulcer in 28 patients: after complete peritoneal toilet and closure of the perforation with an omental flap fibrin sealing completed the approximation of tissues. The follow-up was uneventful in 27 patients, and one death observed in an ASA III patient converted to open surgery due to duodenal wall lesions and delay of operation. In laparoscopic surgery the use of fibrin sealing is helpful and efficient to complete hemostasis and secure sutures.
T Cell Receptor Signals Enhance Susceptibility to Fas-mediated Apoptosis
Authors: Brian Wong, Joseph Arron, Yongwon Choi
Journal: The Journal of Experimental Medicine (1997)

Fas(CD95) and its ligand (FasL) interaction plays a pivotal role in T cell receptor (TCR)-mediated apoptosis. However, the susceptibility of T cells to Fas-mediated apoptosis is tightly regulated during immune responses, a regulation which is thought to maintain the antigen-specificity of T cell apoptosis. Here we show that TCR stimulation enhances the induction of Fas-mediated apoptosis. In addition, using a mutant T cell hybridoma with impaired FasL expression, we show that the synergy provided by TCR stimulation can be mimicked by activators of PKC but not calcium influx. This effect cannot be inhibited by actinomycin D, suggesting that TCR stimulation leads to the alteration in preexisting signaling molecules to enhance Fas-mediated apoptosis. Our results therefore provide a mechanism of how Fas-FasL interactions lead to T cell death in an antigen-specific manner via repetitive antigen stimulation.
Doctors must stay within their competence when giving evidence
Authors: Clare Dyer
Journal: BMJ (2007)

Doctors acting as expert witnesses in court must ensure that they stay within the limits of their professional competence, says draft guidance from the UK General Medical Council. 

The guidance follows controversy over the role of the retired paediatrician Roy Meadow in giving misleading statistical evidence in the case of Sally Clark, a solicitor convicted of murdering her two baby sons and later freed on appeal. 

Professor Meadow gave evidence that proved to be wrong at Mrs Clark's trial in 1999 about the risk of two cot deaths in a family like hers even …
Evaluating Outcomes and Costs in Perioperative Care
Authors: Mark D. Neuman, Lee A. Fleisher
Journal: JAMA Surgery (2013)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Surgery HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Surgery journal
Renal and Hepatic Scintigraphy in Paroxysmal Nocturnal Hemoglobinuria (PNH)
Authors: DOUGLAS L. WILANSKY, LORNE SIDENBERG, LAURIE SILVERBERG
Journal: Clinical Nuclear Medicine (1985)

Scintigraphic findings in paroxysmal nocturnal hemoglobinuria (PNH) have been presented. To summarize, a focal hot spot on liver imaging was better seen on the IDA scan, showing resolution following a satisfactory portacaval anastomosis. PNH is another cause of hot kidneys on bone imaging.
SOME COMPARATIVE RESULTS IN CITIES AND IN COUNTIES AS HEALTH UNITS
Authors: A. J. WARREN
Journal: JAMA (1922)

The incorporated city as a unit of civil organization for the protection of the public health has so thoroughly justified its existence, efforts and expenditures that the question of the propriety of such an organization is no longer debatable. The evidence is all on the affirmative side. Unfortunately, the county as a unit of organized civil efforts for the protection of the health of the people living in the rural communities and small towns is not so universally accepted. That the county as a unit has been neglected in the past is illustrated by the fact that the first position of full-time county health officer in this country was not established until 1911.<sup>1</sup>That the problem is still being treated with indifference is evidenced by the fact that of the 3,065 counties or equivalent divisions of the continental United States, only 161, or 5.2 per cent., were on Jan.