Infiltrative Ophthalmopathy and Primary Hypothyroidism
Authors: ROBERT A. FOX
Journal: Annals of Internal Medicine (1967)

Case Studies1 August 1967Infiltrative Ophthalmopathy and Primary HypothyroidismROBERT A. FOX, M.D., THEODORE B. SCHWARTZ, M.D., F.A.C.P.ROBERT A. FOX, M.D.Search for more papers by this author, THEODORE B. SCHWARTZ, M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-67-2-377 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptExophthalmos and associated eye changes are classically linked with hyperthyroidism in the form of Graves' disease, and the ophthalmopathy may persist or progress in severity even though the euthyroid state is restored or hypothyroidism supervenes. In recent years it has become evident that infiltrative ophthalmopathy may occur in euthyroid individuals in whom there is no evidence of prior hyperthyroidism (1-4). This report is presented primarily to draw attention to the fact that infiltrative ophthalmopathy may also appear in hypothyroid individuals without a previous history of hyperthyroidism.CASE REPORTPatient B. T. (PSLH 795904) is a 40-year-old white housewife who was...References1. WERNER SC: Euthyroid patients with early eye signs of Graves' disease. Ann. Intern. Med. 18: 608, 1955. Google Scholar2. PINCHERAPINCHERASTANBURY AMGJB: Thyrotropin and long-acting thyroid stimulator assays in thyroid disease. J. Clin. Endocr. 25: 189, 1965. CrossrefGoogle Scholar3. LIDDLEHEYSSELMCKENZIE GWRMJM: Graves' disease without hyperthyroidism. Amer. J. Med. 39: 845, 1965. CrossrefMedlineGoogle Scholar4. EVERSMANSKILLERNSENHAUSER JJPGDA: Hashimoto's thyroiditis and Graves' disease with exophthalmos without hyperthyroidism. Cleveland Clin. Quart. 33: 179, 1966. CrossrefGoogle Scholar5. MCKENZIE JM: The bioassay of thyrotropin in serum. Endrocrinology 63: 372, 1958. CrossrefMedlineGoogle Scholar6. 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MASONWALSH REFB: Exophthalmos in hypothyroidism due to Hashimoto's thyroiditis. Bull. Hopkins Hosp. 112: 323, 1963. Google Scholar13. BEALLSOLOMON GNDH: Inhibition of long-acting thyroid stimulator by thyroid particulate fractions. J. Clin. Invest. 45: 552, 1966. CrossrefMedlineGoogle Scholar14. LONG JC: Surgical management of the tropias of thyroid exophthalmos. Arch. Ophthal. (Chicago) 75: 634, 1966. CrossrefMedlineGoogle Scholar15. WYSEMCCONAHEYWOOLNERSCHOLZKEARNS EPWMLBDATP: Ophthalmopathy without hyperthyroidism in patients with histologic Hashimoto's thyroiditis (abstract). American Thyroid Association, Program of the 1966 meeting, Oct. 13-15, p. 46. Google Scholar16. BUCHANANALEXANDERCROOKSKOUTRASWAYNEANDERSONGOUDIE WWWDJDAEJJRRB: Association of thyrotoxicosis and autoimmune thyroiditis. Brit. Med. J. 1: 843, 1961. CrossrefMedlineGoogle Scholar17. GRIBETZTALBOTCRAWFORD DNBJD: Goiter due to lymphocytic thyroiditis (Hashimoto's struma). Its occurrence in preadolescent and adolescent girls. New Eng. J. Med. 250: 555, 1954. CrossrefMedlineGoogle Scholar18. RIVLINMELMONSJOERDSMA RSKLA: An oral tyrosine tolerance test in thyrotoxicosis and myxedema. New Eng. J. Med. 272: 1143, 1965. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: ROBERT A. FOX, M.D.; THEODORE B. SCHWARTZ, M.D., F.A.C.P.Affiliations: Chicago, IllinoisFrom the Section of Endocrinology and Metabolism, Presbyterian-St. Luke's Hospital, and the Department of Medicine, University of Illinois College of Medicine, Chicago, Ill.Requests for reprints should be addressed to Theodore B. Schwartz, M.D., Presbyterian-St. Luke's Hospital, 1753 Congress Pkwy., Chicago, Ill. 60612. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byA Case of Hypothyroid Graves' Disease Following External Radiation Therapy to the Cervical RegionSevere Thyroid Eye Disease Associated with Primary Hypothyroidism and Thyroid-Associated DermopathyMetastatic septic endophthalmitis complicating pyogenic liver abscess caused by Klebsiella pneumoniaeREPLYThe Incidence of Graves' Ophthalmopathy in Olmsted County, MinnesotaHypothyroidismImprovement of infiltrative ophthalmopathy in parallel with decrease of thyroid-stimulating antibody (TSAb) activity in two patients with hypothyroid Graves’ disease4 Autoimmunity and hypothyroidismImmunohistochemical and Ultrastructural Studies on the Exenterated Orbital Tissues of a Patient with Graves' DiseaseOphthalmopathy and Thyroid DisordersHypothyroid Graves' diseaseManagement of the eye manifestations of thyroid diseaseStudies on the Pathogenesis of Graves’ Ophthalmopathy (with Some Related Observations Regarding Therapy)HYPOTHYROIDISM IN PROGRESSIVE OPHTHALMOPATHY OF GRAVES‘ DISEASELymphocytic Thyroiditis and Thyrotoxicosis 1 August 1967Volume 67, Issue 2Page: 377-380KeywordsEndocrinologyEye diseasesHospital medicineHyperthyroidismHypothyroidism ePublished: 1 December 2008 Issue Published: 1 August 1967 PDF downloadLoading ...