tbuckley/cabot-search huggingface dataset:
Doctor, Your Next Patient Is the Rabbit in Room 7
Authors: Walter H. C. Burgdorf
Journal: JAMA Dermatology (2014)

29. Garbe C, Paul A, Kohler-Spath H, et al. Prospective evaluation of a follow-up schedule in cutaneous melanoma patients: recommendations for an effective follow-up strategy. J Clin Oncol. 2003;21(3):520-529. 30. Kricker A, Armstrong BK, Goumas C, et al; GEM Study Group. Survival for patients with single and multiple primary melanomas: the genes, environment, andmelanoma study. JAMA Dermatol. 2013;149(8):921-927.
Must they die.
Authors: W P Stamm
Journal: BMJ (1977)

immigrant children' give a rate of 2 66 per 1000 to be compared with a rate of 0-33 per 1000 from 86 notifications in 263 000 indigenous children.2Far from being lower, the incidence of tuberculosis is eight times higher.As for tuberculin sensitivity, the annual acceptance rate for BCG protection of new- born infants in hospital, so far as our records go, has only once exceeded 70 %.3Either the 96 % BCG acceptance rate for Scottish children in table V is a misprint or the group was unusually highly selected.The authors report that 11 % of "Scottish" children live at a density of over six persons per room, 380% over four persons per room,
Inhibition of the baroreceptor heart rate reflex by angiotensin II in normal man
Authors: P J E MACE, R D S WATSON, W SKAN, W A LITTLER
Journal: Cardiovascular Research (1985)

Journal Article Inhibition of the baroreceptor heart rate reflex by angiotensin II in normal man Get access P J E MACE, P J E MACE Search for other works by this author on: Oxford Academic PubMed Google Scholar R D S WATSON, R D S WATSON **Department of Cardiology, Dudley Road Hospital Search for other works by this author on: Oxford Academic PubMed Google Scholar W SKAN, W SKAN Search for other works by this author on: Oxford Academic PubMed Google Scholar W A LITTLER W A LITTLER Search for other works by this author on: Oxford Academic PubMed Google Scholar Cardiovascular Research, Volume 19, Issue 9, September 1985, Pages 525–527, https://doi.org/10.1093/cvr/19.9.525 Published: 01 September 1985
Global mortality from conditions with skin manifestations
Authors: Lindsay N. Boyers, Chante Karimkhani, Mohsen Naghavi, David Sherwood, David J. Margolis, Roderick J. Hay, Hywel C. Williams, Luigi Naldi, Luc E. Coffeng, Martin A. Weinstock, Cory A. Dunnick, Hannah Pederson, Theo Vos, Robert P. Dellavalle
Journal: Journal of the American Academy of Dermatology (2014)
Restoration of Endothelium-Dependent Vasodilation After Reperfusion Injury by Tetrahydrobiopterin
Authors: Christiane P. Tiefenbacher, William M. Chilian, Michael Mitchell, David V. DeFily
Journal: Circulation (1996)

Background A deficit in the endothelial production of nitric oxide (NO) is associated with the sequelae of reperfusion injury. Because endothelial NO synthesis depends on the cofactor tetrahydrobiopterin (BH4), we hypothesized that depletion of this cofactor underlies the reduction of endothelium-dependent dilation in reperfusion injury. Methods and Results After occlusion of the left anterior descending coronary artery of a pig for 60 minutes followed by 90 minutes of reperfusion (ischemia/reperfusion), hearts were removed and the arterioles were isolated, cannulated, pressurized, and placed on an inverted microscope stage. Dose responses to the endothelium-independent dilator sodium nitroprusside and the endothelium-dependent dilators serotonin, A23187, and substance P were obtained under control conditions, after incubation with sepiapterin (intracellularly converted to BH4) or synthetic BH4 6-methyltetrahydropterin (MH4), and again after their washout. After ischemia/reperfusion, sodium nitroprusside maximally dilated arterioles (99±3%), whereas relaxation to serotonin, A23187, and substance P was significantly reduced (19±9%, 44±9%, and 54±8%, respectively). During incubation with sepiapterin (1 μmol/L) or MH4 (10 μmol/L), endothelium-dependent dilation was significantly enhanced ( P &lt;.05), whereas the response to sodium nitroprusside was unaltered. After washout, the vasodilatory responses were not significantly different from the initial ischemia/reperfusion responses. Sepiapterin and MH4 did not affect vasodilatory responses in vessels obtained from nonischemic control hearts. As after ischemia/reperfusion, incubation of control vessels with 2,4-diamino-6-hydroxypyrimidine, an inhibitor of GTP cyclohydrolase I, decreased endothelium-dependent vasodilation, which was restored in the presence of sepiapterin or MH4. Conclusions These data indicate that exogenous administration of sepiapterin or MH4 restores the response to endothelium-dependent vasodilators in pig coronary arterioles after ischemia/reperfusion. We therefore conclude that ischemia/reperfusion alters the availability or production of BH4, which contributes to blunted endothelial nitroxidergic vasodilation.
The growth of vibrissa dermal papilla cells in vitro
Authors: C. JAHODA, R.F. OLIVER
Journal: British Journal of Dermatology (1981)

Journal Article The growth of vibrissa dermal papilla cells in vitro Get access C. JAHODA, C. JAHODA Department of Biological Sciences, University of Dundee, Dundee, Scotland Search for other works by this author on: Oxford Academic Google Scholar R.F. OLIVER R.F. OLIVER Department of Biological Sciences, University of Dundee, Dundee, Scotland Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 105, Issue 6, 1 December 1981, Pages 623–627, https://doi.org/10.1111/j.1365-2133.1981.tb00971.x Published: 01 December 1981 Article history Accepted: 04 February 1981 Published: 01 December 1981
1046-176 Preoperative hemodynamic status as a predictor of surgical mortality in acute type A aortic dissection patients: Insights from the International Registry of Acute Aortic Dissection (IRAD)
Authors: Santi Trimarchi, Rossella Fattori, Christoph A Nienaber, Jeanna V Cooper, Dean E Smith, Vincenzo Rampoldi, Giuseppe Sangiorgi, Truls Myrmel, Toru Suzuki, Jae K Oh, Eric M Isselbacher, Kim A Eagle
Journal: Journal of the American College of Cardiology (2004)
Acute type A, B, and non-A, non-B hepatitis in a hospital population in London: clinical and epidemiological features.
Authors: M Bamber, H C Thomas, B Bannister, S Sherlock
Journal: Gut (1983)

The aetiology of acute viral hepatitis in 172 patients admitted to an infectious diseases hospital in North London was: hepatitis A in 88 (51%), hepatitis B in 58 (34%), Epstein-Barr (EB) virus in four (2%) and non-A, non-B in 22 (13%). NANB hepatitis was a milder disease than that associated with the other viruses. It predominantly occurred in young men (77%). In half of the cases there was evidence of parenteral transmission. It was not transmitted by sexual contact.
Cholecystectomy in a Trial of Adjuvant Chemotherapy After Pancreatic Cancer Resection
Authors: Attila Dubecz, Jens Köhler, Hubert J. Stein
Journal: JAMA (2010)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Routine Laboratory Tests in Impaired Nursing Home Residents-Reply
Authors: David Kim
Journal: JAMA (1995)

In Reply.  —We thank Dr Richardson for his comments and second his caution regarding our study's implications. We also emphasize that our results do not support the casual notion that all assessments of the nursing home patient are useless. Management of complex elderly patients requires a high level of critical thinking and decision making, particularly concerning conventional tests used in the traditional medical model. Our study addressed only one of these traditional assessment tools, namely, the comprehensive laboratory test battery. We do not quite agree that these tests have been debunked. Rather, we believe our results enable clinicians to customize and fine-tune the use of these tests to individual patients.  Our overriding intention was to discourage automatic, unthinking laboratory testing and to encourage the more thoughtful approach of explicitly identifying one's purpose in ordering tests. As confirmed by our study, the value of testing varies among screening, monitoring, follow-up, and
Urinary electrolyte excretion, alcohol consumption, and blood pressure in the Scottish heart health study.
Authors: W. C. Smith, I. K. Crombie, R. T. Tavendale, S. K. Gulland, H. D. Tunstall-Pedoe
Journal: BMJ (1988)

As part of a study of risk factors for coronary heart disease 24 hour urine collections were obtained from 7354 men and women aged 40-59 selected at random from 22 districts throughout Scotland (Scottish heart health study). The mean of two standardised measurements of blood pressure was related to the reported consumption of alcohol and measurements of height, weight, pulse rate, and electrolyte excretion. Several significant correlations were found with both systolic and diastolic pressure, but only the coefficients for age, body mass index, and pulse rate were greater than 0.1. Alcohol consumption showed a weak positive correlation with blood pressure in men. Sodium excretion showed a weak positive correlation with blood pressure in both sexes, and potassium excretion showed weak negative correlations. In multiple regression analysis age, pulse rate, body mass index, alcohol consumption, and potassium excretion had significant independent effects but sodium excretion did not. Although measuring blood pressure twice on one occasion and 24 hour urinary sodium excretion only once may have weakened any potential correlation, the most likely explantation of these results is that the relation between sodium and blood pressure in the population is weak and that potassium and alcohol are of greater importance.
Does Magnesium Prevent Myocardial Infarction?-Reply
Authors: Joel Gore
Journal: JAMA (1993)

<h3>In Reply.</h3> —The combined results of the US and British physicians studies were reported by collaborators from those two studies. They stated, "It may be appropriate to consider their results together despite several substantial differences in design."<sup>1</sup> Mr Nugent's observation that the US study used Bufferin, whereas the British study used "pure" aspirin, is correct. Bufferin (325 mg) contains approximately 57 mg of magnesium, whereas pure aspirin does not contain magnesium (written communication, Robert J. Lipsy, PharmD, Arizona Poison and Drug Information Center, Tucson, Ariz, December 1992). It should be noted that the Recommended Daily Allowance for magnesium is 400 mg. Nugent's suggestion that the beneficial effect of aspirin in the US study was due to the small amount of magnesium contained in Bufferin seems unlikely. The vast majority of studies reporting a beneficial effect of aspirin in patients with coronary artery disease used pure aspirin without magnesium.
Fibrosis-induced reduction of endomyocardium in the rat after isoproterenol treatment.
Authors: J E Jalil, J S Janicki, R Pick, C Abrahams, K T Weber
Journal: Circulation Research (1989)

Isoproterenol treatment leads to endomyocardial fibrosis with muscle fibers encircled by fibrillar collagen. This study was undertaken in the rat to determine if muscle encased in collagen would subsequently become either necrotic or atrophic. For this purpose, we monitored the fibrillar nature of myocardial collagen, its alignment with muscle, and the morphology of the endomyocardium, together with the response in diastolic and systolic myocardial stiffness, immediately on completion (10 days) and 30 days after a course of subcutaneous isoproterenol (500 micrograms/kg/day). We found 1) left ventricular hypertrophy at 10 and 30 days with an increase in collagen volume fraction (p less than 0.01) that consisted of a meshwork of thick and thin collagen fibers that encircled endomyocardial muscle, 2) a variable reduction in endocardial muscle fiber diameter at 30 days with the greatest thinning seen in muscle encircled by fibrous tissue, and 3) an elevation (p less than 0.01) in the slope of the diastolic stress-strain relation at 10 and 30 days. The developed systolic stress-strain relation, which was elevated at 10 days (p less than 0.01), declined (p less than 0.05) with the reduction in endomyocardial muscle mass. Thus, endomyocardial muscle, encircled by fibrillar collagen, will atrophy over time, and this leads to a reduction in active stiffness. These findings may, in part, explain why progressive ventricular dysfunction accompanies chronic myocardial disease with endomyocardial fibrosis.
Dr. Paquin's Serum.
Authors: J. R. Lemen
Journal: JAMA (1897)

St. Louis, Sept. 6, 1897. <h3>To the Editor:</h3> —In theJournalof Aug. 21, 1897, Dr. Paul Paquin mentions my name as one of a number of physicians who "used serum and are still using it." There appeared in the<i>New York Medical Journal</i>, Sept. 1, 1895, a report by me of a case of tuberculosis, for which I recommended the use of Paquin's anti-tubercle serum. The patient recovered. The report of this case has been used extensively to advertise Dr. Paquin's serum. I made an extensive trial of the serum for some months after the recovery of this patient, but the results were either negative, or they appeared to be similar to those following the use of Koch's old tuberculin. As the serum was injurious and dangerous to my patients, I discontinued its administration. I do not, under any circumstances, wish to be considered as indorsing the Paquin anti-tubercle
Congenital Communications of the Right Pulmonary Veins with the Azygos Vein
Authors: HOWARD N. ANDERSON, WARREN G. GUNTHEROTH, LOREN C. WINTERSCHEID, K. ALVIN MERENDINO
Journal: Circulation (1964)

A case of total pulmonary venous drainage of the right lung into the azygos vein, surgically corrected, has been reported. There have been 10 previous cases of varying degrees of partial right, total right, to total (bilateral) pulmonary venous drainage into the azygos vein. The authors' case is the third to be diagnosed during life and apparently the first case to be successfully corrected. With one exception, all previously reported cases have occurred in females. A review of previous cases and surgical considerations in the authors' case have been presented.
Prevalence of XYY and XXY Karyotypes in 337 Nonretarded Young Offenders
Authors: Ernest B. Hook, Dong-Soo Kim
Journal: New England Journal of Medicine (1970)

IN view of the reports of XYY karyotypes in many adult males with criminal histories, a question of some social as well as genetic interest is the extent to which the XYY genotype is associated with antisocial behavior in children and adolescents. However, to date no systematic study of boys under the age of 16 has appeared.In an attempt to investigate this question a study of all inmates of two institutions for nonretarded (IQ over 70), nonpsychotic juvenile offenders was performed. In the state investigated, Institution A accepts all such boys under 13 referred there by the courts. Boys . . .
Psychiatric Aspects of Normal Pressure Hydrocephalus
Authors: Emanuel Rice
Journal: JAMA (1973)

Five patients had normal pressure hydrocephalus (NPH) within the context of a psychiatric dimension. The incidence of NPH is highest in the older age group. Psychiatric sequelae can be the predominant, as well as initial, clinical manifestation of this syndrome. Normal pressure hydrocephalus is an organic brain syndrome that is potentially reversible by a neurosurgical shunting procedure. The mental status of the patient and the necessity for the inclusion of NPH in the differential diagnosis are important.
Abstract 5636: Different characteristics of drug resistance in AML cell lines between a dual Flt3/CDK4 kinase inhibitor AMG 925 and Flt3 inhibitors.
Authors: Cong Li, Lingming Liang, Darrin Beaupre, Katie Newhall, Zhihong Li, Queenie Wang, Zhen Xia, Qiang Liu, Larry McGee, Dineli Wickramasinghe, Kang Dai
Journal: Cancer Research (2013)

Abstract Objectives: Flt3 inhibitors have shown clinical responses in Flt3 mutant acute myeloid leukemia (AML) but resistance develops rapidly. In order to improve the durability of clinical response of AMLFlt3 MUT, a small molecule inhibitor of Flt3 and CDK4/6 kinases, AMG 925, was developed. The primary purpose of this study is to compare the ability of AML cell lines to become resistant to AMG 925 and to other Flt3 inhibitors, and to elucidate the underlying molecular mechanisms. Methods: Drug resistant MOLM13 and Mv4-11 cell clones were isolated by prolonged exposure to increasing concentrations of AMG 925 and other Flt3 inhibitors. Cell proliferation was determined by CellTiter Glo. Protein expression levels were assessed by Western Blotting, IP Western Blotting and MSD assays. Flt3 mRNA levels were measured by RT-PCR. Results and Conclusions: Both MOLM13 and Mv4-11 cells developed resistance to all the inhibitors tested within 3-4 months. In contrast to AML cells resistant to other Flt3 inhibitors (IC50 increased by about 1000 fold), cells resistant to AMG 925 were only at much lower drug concentrations (IC50 increased by 3-5 fold). Mutations in the Flt3 kinase domains were found in cells resistant to the other Flt3 inhibitors but not in those resistant to AMG 925. P-Flt3 and P-STAT5 in AMG 925 resistant cells were less inhibited than in the sensitive parental cells, apparently as a result of an increased total Flt3 (2-3 fold) in the resistant cells. These results are consistent with the hypothesis that it is more challenging for AML cells to develop drug resistance against combined inhibition of Flt3 and CDK4/6 (AMG 925) than against inhibition of Flt3 alone. Citation Format: Cong Li, Lingming Liang, Darrin Beaupre, Katie Newhall, Zhihong Li, Queenie Wang, Zhen Xia, Qiang Liu, Larry McGee, Dineli Wickramasinghe, Kang Dai. Different characteristics of drug resistance in AML cell lines between a dual Flt3/CDK4 kinase inhibitor AMG 925 and Flt3 inhibitors. [abstract]. In: Proceedings of the 104th Annual Meeting of the American Association for Cancer Research; 2013 Apr 6-10; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2013;73(8 Suppl):Abstract nr 5636. doi:10.1158/1538-7445.AM2013-5636
Role of membrane glycoproteins in mediating trophic responses.
Authors: R Tauber, W Reutter, W Gerok
Journal: Gut (1987)

During growth and differentiation the plasma membrane has a key role not only in the reception and transmission of extracellular signals such as hormones and growth factors, but also in communicating cellular response to the cellular microenvironment. Cellular response to trophic stimuli includes alterations of cell shape and cell surface antigenicity, of cell-cell recognition and cellular adhesion, of cell matrix binding and the adaptation of cell surface receptors. The plasma membrane is therefore regarded as a 9central agency9 for the integration of a single cell into the complex system of a tissue or of an organism. The numerous functions of the plasma membrane are mainly mediated by membrane integrated glycoproteins or glycolipids both sharing the common feature of covalently bound oligosaccharide side chains. Specific alterations of oligosaccharide structure and metabolism associated with growth, differentiation and various pathologic conditions suggest a specific role for the oligosaccharide moieties in the regulation of cell surface functions (Table 1). This review intends to focus on the role of plasma membrane glycoproteins describing briefly principles of glycoprotein structure and function, and characteristics of their biosynthesis and degradation.
Safety and pharmacokinetics of dose-intensive imatinib mesylate plus temozolomide: Phase 1 trial in adults with malignant glioma
Authors: David A. Reardon, Annick Desjardins, James J. Vredenburgh, Sith Sathornsumetee, Jeremy N. Rich, Jennifer A. Quinn, Theodore F. Lagattuta, Merrill J. Egorin, Sridharan Gururangan, Roger McLendon, James E. Herndon, Allan H. Friedman, August J. Salvado, Henry S. Friedman
Journal: Neuro-Oncology (2008)

We determined the maximum tolerated dose (MTD) and dose-limiting toxicity (DLT) of imatinib mesylate, an inhibitor of the receptor tyrosine kinases platelet-derived growth factor receptor (PDGFR), the proto-oncogene product c-kit, and the fusion protein Bcr-Abl, when administered for 8 days in combination with temozolomide (TMZ) to malignant glioma (MG) patients. MG patients who had not failed prior TMZ were eligible to receive TMZ at a dose of 150-200 mg/m(2) per day on days 4-8 plus imatinib mesylate administered orally on days 1-8 of each 4-week cycle. Patients were stratified based on concurrent administration of CYP3A4-inducing antiepileptic drugs (EIAEDs). The imatinib dose was escalated in successive cohorts of patients independently for each stratum. Imatinib, at doses ranging from 400 mg to 1,200 mg, was administered with TMZ to 65 patients: 52 (80%) with glioblastoma multiforme (GBM) and 13 (20%) with grade III MG. At enrollment, 34 patients (52%) had stable disease, and 33 (48%) had progressive disease; 30 patients (46%) were on EIAEDs. The MTD of imatinib for patients concurrently receiving or not receiving EIAEDs was 1,000 mg. DLTs were hematologic, gastrointestinal, renal, and hepatic. Pharmacokinetic analyses revealed lowered exposures and enhanced clearance among patients on EIAEDs. Among GBM patients with stable disease at enrollment (n=28), the median progression-free and overall survival times were 41.7 and 56.1 weeks, respectively. Imatinib doses up to 1,000 mg/day for 8 consecutive days are well tolerated when combined with standard TMZ dosing for MG patients. A subsequent phase 2 study is required to further evaluate the efficacy of this regimen for this patient population.