Pernicious Anemia as a Deficiency Disease
Authors: Randolph West
Journal: Annals of Internal Medicine (1929)

Article1 August 1929Pernicious Anemia as a Deficiency DiseaseRANDOLPH WESTRANDOLPH WESTSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-3-2-132 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptIn discussing the nature of Pernicious Anemia, we wish to confine ourselves strictly to the idiopathic anemia described by Addison and later by Biermer, and differentiate it as sharply as possible from other anemias with similar blood pictures.In Addisonian Anemia three organ systems are dominantly affected, the gastro-intestinal tract, the blood, and the central nervous system.The lesions in the gastrointestinal tract are glossitis, and an achylia gastrica associated with an atrophy of the gastric mucosa. Both pepsin and HCl are lacking in the gastric secretions, and injections of histamine do not lead to any secretion of acid as...References1 LEVINELADD : Pernicious anemia. Johns Hopkins Hospital Bulletins, 1921, XXXII, 254. Google Scholar2 HURST : Lancet, 1925, I, 255. Google Scholar3 WILKINSON : Cited by FEBER and NYFELDT. Anämie und Intestinaltractus. Ergebnisse der gesamten Medizin, 1928, XI, 273. Google Scholar4 HARTMAN : Blood changes in a gastrectomized patient simulating those in pernicious anemia. Am. J. Med. Sc., 1921, August. CrossrefGoogle Scholar5 MOYNIHAN : A case of complete gastrectomy. Lancet, 1911, XI, 430. CrossrefGoogle Scholar6 MULLERGOODECASTLEROSE : Relation of cholesterol and lecithin to remission in pernicious anemia. Proc. Soc. Exp. Biol. and Med., XXV, 567, 1927. Google Scholar7 PEABODY : Am. J. Path., 1927, III, 197. Google Scholar8 MINOTCOHNMURPHYLAWSON : The treatment of pernicious anaemia with liver extract. Effects upon the productions of immature and mature red blood corpuscles. Am. J. Med. Sci., 1928, CLXXV, 599. CrossrefGoogle Scholar9 COLLIER : Oxford Medicine. Google Scholar10 DRAPER : Human Constitution (Saunders, Phila.), 1924. Google Scholar11 COHNMINOTALLESSALTER : The nature of the material in liver effective in pernicious anemia. II. J. Biol. Chem., 1928, LXXVII, 325. CrossrefGoogle Scholar12 WESTNICHOLS Liver Fractions in Pernicious Anemia: , J. A. M. A., 1928, XCI, 867. CrossrefGoogle Scholar13 MCCANNELDER : Effect of liver ash on blood regeneration in pernicious anemia. Proc. Soc. Exp. Biol. and Med., 25, 747. Google Scholar14 CASTLELOCKE : Observations on the etiological relationship of achylia gastrica to pernicious anemia. Read at the meeting of the American Society for Clinical Investigation, Washington, April, 1928. Google Scholar15 MORTONKAHNTORREY : A pernicious anemia-like blood condition produced in monkeys with bacterium Welchii toxin. Proceedings of the Society for Experimental Biology and Medicine, 1925, XXIII, 8. Google Scholar16 ASHFORD : Evaluation of liver extract in treatment of anemias of sprue. J.A.M.A., 1928, XCI, 242. CrossrefGoogle Scholar17 SYDERHELM : Die Behandlung der perniziözen Anämie. Verhandlungen der Deutschen Gessellschaft für Innere Medizin, 1928, 315. CrossrefGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Medical Clinic Columbia University Presbyterian Hospital New York*Read before the American College of Physicians, Boston, April 8, 1929. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byChemistry of Anti-Pernicious Anemia Substances of LiverPhysiologie und Pathologie des Antiperniciosaprinzips 1 August 1929Volume 3, Issue 2Page: 132-136KeywordsBloodCentral nervous systemGastric mucosaGastroenterology and hepatologyGastrointestinal tractHistamineHydrochloric acidLesionsPepsinsPernicious anemia Issue Published: 1 August 1929 PDF downloadLoading ...