OBSERVATION ON THE GENESIS OF CRISES IN SICKLE CELL ANEMIA
Authors: J C PATERSON, C C SPRAGUE
Journal: Annals of Internal Medicine (1959)

Case Reports1 June 1959OBSERVATION ON THE GENESIS OF CRISES IN SICKLE CELL ANEMIAJ. C. S. PATERSON, C. C. SPRAGUEJ. C. S. PATERSONSearch for more papers by this author, C. C. SPRAGUESearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-50-6-1502 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe periodic crises which punctuate the natural course of sickle cell anemia were separated by Singer and his colleagues17in 1950 into the following categories: (a) the "aplastic" crisis, (b) the "hyperhemolytic" crisis, and (c) "the aplastic-hyperhemolytic" crisis, in which there is both an abeyance of the delivery of cells from the marrow and an increase in the rate of hemolysis of the circulating red cells. This hematologic classification has been generally accepted, but with more emphasis put upon the "thrombotic," "infarctive" or "symptomatic" crisis, an episode of fever and pain, without any significant change in the hemoglobin level.9, 19,...Bibliography1. AndersonBusby GWT: Sickle cell anemia and pregnancy, Am. J. Obst. and Gynec. 58: 75, 1949. CrossrefMedlineGoogle Scholar2. Barcroft J: The respiratory function of the blood. Part II. Haemoglobin, 2nd Ed., 1928, Cambridge University Press, London. Google Scholar3. BauerFisher JLJ: Sickle cell disease with special regard to its nonanemic variety, Arch. Surg. 47: 553, 1943. CrossrefGoogle Scholar4. BeachamBeacham WDDW: Sickle-cell disease and pregnancy, Am. J. Obst. and Gynec. 60: 1217, 1950. CrossrefMedlineGoogle Scholar5. ConleyMartinRecinos JRMBA: Sickle cell anemia. Special report, Clin. Proc. Child. Hosp. 6: 101, 1950. Google Scholar6. Connell JH: Cerebral necrosis in sickle cell disease, J. A. M. A. 118: 893, 1942. 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Watson RJ: The hereditary anemias, Bull. New York Acad. Med. 30: 106, 1954. MedlineGoogle Scholar20. WatsonLichtmanShapiro RJHCHD: Splenomegaly in sickle cell anemia, Am. J. Med. 20: 196, 1956. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: New Orleans, Louisiana*Received for publication October 22, 1957.From the Department of Medicine, Tulane University Medical School, New Orleans, Louisiana.†This observation was made in the course of studies undertaken in connection with an award to Dr. G. E. Burch, Chairman of the Department of Medicine, by the John Simon Guggenheim Memorial Foundation for studies of sickle cell anemia and of methods for its treatment.Requests for reprints should be addressed to J. C. S. Paterson, M.D., Department Tropical Medicine and Public Health, The Tulane University of Louisiana, 1430 Tulane Avenue, New Orleans 12, Louisiana. 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