THE SYNDROME OF PRECOCIOUS PUBERTY, FIBROCYSTIC BONE DISEASE AND PIGMENTATION OF THE SKIN: ELEVEN YEARS' OBSERVATION OF A CASE
Authors: Bernard M. Scholder
Journal: Annals of Internal Medicine (1945)

Case Reports1 January 1945THE SYNDROME OF PRECOCIOUS PUBERTY, FIBROCYSTIC BONE DISEASE AND PIGMENTATION OF THE SKIN: ELEVEN YEARS' OBSERVATION OF A CASEBERNARD M. SCHOLDERBERNARD M. SCHOLDERAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-22-1-105 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptIn 1922 Weil1 first described the syndrome of precocious puberty, fibrocystic bone disease and pigmentation of the skin. Since then there have been reports of some 18 cases.2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14 These are presented in table 1. Although the syndrome is interesting because it is uncommon and bizarre, its chief appeal arises from attempts to explain the various phenomena in the light of present day knowledge of neuro-endocrine mechanisms.The patient to be presented has been under constant medical scrutiny since the onset of symptoms at the age of three, and...Bibliography1. WEIL : Pubertas praecox und Knochenbrüchigkeit, Klin. Wchnschr., 1922, i, 2114. Google Scholar2. GAUPP V: Pubertas praecox bei Osteodystrophia fibrosa, Monatschr. f. Kinderh., 1932, liii, 312. Google Scholar3. FREEDMAN HJ: Disturbances of function of the suprarenal glands in children, Am. Jr. Dis. Child., 1932, xliv, 1285. Google Scholar4. STALMANN A: Nerven-, Haut-, und Knochenveränderungen bei der Neurofibromatosis Recklinghausen und ihre entstehungsgeschichtlichen Zusammenhänge, Virchow's Arch. f. path. Anat., 1933, cclxxxix, 96. CrossrefGoogle Scholar5. SNAPPERPARISEL IC: Xanthomatosis generalisata ossium, Quart. Jr. Med., 1933, ii, 407. Google Scholar6. GOLDHAMMER K: Osteodystrophia fibrosa unilateralis (kombiniert mit Pubertas praecox und mit gleichseitigen osteosklerotischen Veränderungen des Schädels), Fortsch. a. d. Geb. d. Röntgenstrahlen, 1934, xlix, 456. Google Scholar7. MCCUNEBRUCH DJH: Osteodystrophia fibrosa, Am. Jr. Dis. Child., 1937, liv, 806. CrossrefGoogle Scholar8. ALBRIGHTBUTLERHAMPTONSMITH FAMAOP: Syndrome characterized by osteitis fibrosa disseminata, areas of pigmentation and endocrine dysfunction, with precocious puberty in females, New Eng. Jr. Med., 1937, ccxvi, 727. CrossrefGoogle Scholar9. MONDORDUCROQUETLEGERLAURENCE HRLG: Sur un cas d'ostéite fibrokystique unilatérale avec pigmentation et puberté précoce, Rev. gén. de clin. et de thérap., 1938, lii, 823-824. Google Scholar10. SUMMERFELDTBROWN PA: Osteodystrophia fibrosa, Am. Jr. Dis. Child., 1939, lvii, 90-101. Google Scholar11. ROBSONTODD KJW: Fibrocystic bone disease with skin pigmentation and endocrine dysfunction, Lancet, 1939, i, 372-380. Google Scholar12. BRAID F: Osseous dystrophy following icterus gravis neonatorum. Generalized osteitis fibrosa with areas of pigmentation of skin and precocious puberty in female, Arch. Dis. Child., 1939, xiv, 181-202. CrossrefGoogle Scholar13. DIEZ J: La osteitis fibrosa diseminada con puberbad precoz y pigmentaciones cutaneas (sindrome de Albright), Prensa med. argent., 1939, xxvi, 1870-1897. Google Scholar14. DOCKERTYMEYERDINGWALLACE MBHWGT: Albright's syndrome (fibrous dysplasia of bones with cutaneous pigmentation in both sexes and gonadal dysfunction in females), Proc. Staff Meet. Mayo Clin., 1944, xix, 81-88. Google Scholar15. LICHTWITZ L: Functional pathology, 1941, Grune and Stratton, New York. Google Scholar16. STERNBERGJOSEPH WHV: Osteodystrophia fibrosa combined with precocious puberty and exophthalmic goiter, Am. Jr. Dis. Child., 1942, lxiii, 748-783. CrossrefGoogle Scholar17. NOVAK E: The constitutional type of female precocious puberty with a report of 9 cases, Am. Jr. Obst. and Gynec., 1944, xlvii, 20-42. CrossrefGoogle Scholar18. WEINBERGERGRANT LMFC: Precocious puberty and tumors of the hypothalamus. Report of a case and review of the literature with a physiologic explanation of the precocious sexual syndrome, Arch. Int. Med., 1941, lxvii, 762-792. CrossrefGoogle Scholar19. BINGGLOBUSSIMON JFJHHJ: Pubertas praecox: a survey of the reported cases and verified anatomical findings, with particular reference to tumors of the pineal body, Jr. Mount Sinai Hosp., 1938, iv, 935. Google Scholar20. SMITHDORTZBACH PEC: The first appearance in the anterior pituitary of the developing pig fetus of detectable amounts of the hormones stimulating ovarian maturity and general body growth, Anat. Rec., 1929, xliii, 277. CrossrefGoogle Scholar21. FORDGUILD FRH: Precocious puberty following measles encephalomyelitis and epidemic encephalitis, Bull. Johns Hopkins Hosp., 1937, lx, 192. Google Scholar22. BESTTAYLOR CHNB: The physiological basis of medical practice, 1943, Williams and Wilkins, Baltimore. Google Scholar23. BREMER JL: Osteitis fibrosa localisata, Arch. Path., 1941, xxxii, 200-210. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: M.C. U.S.N.R. Mount Vernon, New York*Received for publication July 11, 1944.The opinions and assertions contained herein are those of the writer and are not to be construed as official or reflecting the views of the Navy Department or of the Naval Service at large. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byHormonale Osteopathien im ErwachsenenalterHormonale Osteopathien im ErwachsenenalterFibrosarcoma complicating polyostotic fibrous dysplasiaOsteopathienDie Röntgendiagnostik der SchädelbasisDie Röntgendiagnostik der SchädelbasisUNILATERAL DYSPLASIA OF BONE IN AN ELDERLY WOMANSonstige Erkrankungen der Schädelknochen von gewisser neurochirurgischer BedeutungDie Keimdrüsen und ihre KrankheitenPolyostotische fibröse DysplasiePrecocious sexual development 1 January 1945Volume 22, Issue 1Page: 105-118KeywordsBoneGratitudePuberty Issue Published: 1 January 1945 PDF downloadLoading ...