tbuckley/cabot-search huggingface dataset:
935 Dedifferentiation of hepatocyte may proceed and prime the liver for hypercarcinogenic stage in the HBX transgenic mouse
Authors: S OKOSHI, Y TAKEDA, M YANO, K SUZUKI, Y AOYAGI
Journal: Hepatology (2003)

HIV infected individuals have poorer response to hepatitis B vaccine (HBV) compared to normal host. Intradermal administration (ID) facilitates the exposure of antigen to antigen-presenting cells compared to intramuscular administration (IM).HIV-infected children aged 1–18 years with CD4% ≥ 15% or 200 cells/mm3 who had negative HBs Ag, antiHBs, and antiHBc were randomized to receive 3-dose of HBV via ID (2 μg/dose) or IM (10 μg/dose) route at months 0, 2, and 6. AntiHBs titers were measured at months 2, 6 and 7 after first HBV. AntiHBs ≥ 10 mIU/mL was considered protective and AntiHBs > 100 mIU/mL was considered good response.Participants included 41 in ID and 39 in IM arms. 64% had completed 3-doses HBV during infancy. The mean (SD) of age, nadir CD4% and current CD4% were 12 (3.3) years, 10.6 (7.9)% and 28 (8.0)% respectively. 91% were on HAART and 84% had undetectable HIV-RNA.Proportion of children with protective antiHBs in ID vs. IM group were 19.5% vs. 25.6% at month 2, 56.1% vs. 76.9% at month 6, and 90.2% vs. 92.3% at month 7 (NS, all). The geometric mean (95% confidence interval) of antiHBs titer in ID vs. IM group were 112.5 (34.4–367.6) vs. 141.2 (49.4–404.1) mIU/mL at month 2 (p = 0.74), 70.4 (39.8–124.4) vs. 132.1 (79.4–219.8) mIU/mL at month 6 (p = 0.10), and 157.0 (103.0–239.3) vs. 458.9 (324.0–647.0) mIU/mL at month 7 (p < 0.001). However, only 56.1% of the ID arm had good response to HBV compared to 82.1% in the IM arm (p = 0.01). The predictors for being a good responder to HBV were IM administration [OR 4.0, 95%CI 1.4–11.8, p = 0.012] and body weight <35 kg at baseline [OR 3.8, 95%CI 1.3–10.8, p = 0.013]. No adverse events grade 3/4 occurred.In conclusion, HIV-infected children without severe immune suppression, both ID and IM routes of HBV resulted in similar rates of protective antibody titers. However, high antibody titers to HBV were more common with IM; therefore, IM administration is preferred.
Book Review Osteoporosis: Pathophysiology and Clinical Management (Contemporary Endocrinology.) Edited by Eric S. Orwoll and Michael Bliziotes. 615 pp., illustrated. Totowa, N.J., Humana Press, 2003. $135. 0-89603-933-1
Authors: Stavros C. Manolagas
Journal: New England Journal of Medicine (2003)
Buried Bumper Syndrome: Endoscopic Management Using a Balloon Dilator
Authors: P. Strock, J. Weber
Journal: Endoscopy (2005)

A nursing-home resident with a percutaneous endoscopic gastrostomy (PEG) feeding tube (Freka CH 15; Fresenius, Bad Homburg, Germany) presented with resistance to flow of feed. Mobilization of the tube proved impossible. Endoscopy with the patient under intravenous sedation confirmed the buried bumper syndrome, with the internal bolster being completely buried. Only the lumen of the internal tube remained partially visible (Fig. [1]). Attempts at extraction using endoscopic snare or forceps proved unsuccessful.
Putting content into a vehicle theory of consciousness
Authors: Gerard O'Brien, Jonathan Opie
Journal: Behavioral and Brain Sciences (1999)

The connectionist vehicle theory of phenomenal experience in the target article identifies consciousness with the brain's explicit representation of information in the form of stable patterns of neural activity. Commentators raise concerns about both the conceptual and empirical adequacy of this proposal. In the former regard, they worry about our reliance on vehicles, representation, stable patterns of activity, and identity. In the latter regard, their concerns range from the general plausibility of a vehicle theory to our specific attempts to deal with the dissociation studies. We address these concerns, and then finish by considering whether the vehicle theory we have defended has a coherent story to tell about the active, unified subject to whom conscious experiences belong.
Recovery of cardiac calcium release is controlled by sarcoplasmic reticulum refilling and ryanodine receptor sensitivity
Authors: Hena R. Ramay, Ona Z. Liu, Eric A. Sobie
Journal: Cardiovascular Research (2011)

In heart cells, the mechanisms underlying refractoriness of the elementary units of sarcoplasmic reticulum (SR) Ca2+ release, Ca2+ sparks, remain unclear. We investigated local recovery of SR Ca2+ release using experimental measurements and mathematical modelling. Repeated Ca2+ sparks were induced from individual clusters of ryanodine receptors (RyRs) in quiescent rat ventricular myocytes, and we examined how changes in RyR gating influenced the time-dependent recovery of Ca2+ spark amplitude and triggering probability. Repeated Ca2+ sparks from individual sites were analysed in the presence of 50 nM ryanodine with: (i) no additional agents (control); (ii) 50 µM caffeine to sensitize RyRs; (iii) 50 µM tetracaine to inhibit RyRs; or (iv) 100 nM isoproterenol to activate β-adrenergic receptors. Sensitization and inhibition of RyR clusters shortened and lengthened, respectively, the median interval between consecutive Ca2+ sparks (caffeine 239 ms; control 280 ms; tetracaine 453 ms). Recovery of Ca2+ spark amplitude, however, was exponential with a time constant of ∼100 ms in all cases. Isoproterenol both accelerated the recovery of Ca2+ spark amplitude (τ = 58 ms) and shortened the median interval between Ca2+ sparks (192 ms). The results were recapitulated by a mathematical model in which SR [Ca2+] depletion terminates Ca2+ sparks, but not by an alternative model based on limited depletion and Ca2+-dependent inactivation of RyRs. Together, the results strongly suggest that: (i) local SR refilling controls Ca2+ spark amplitude recovery; (ii) Ca2+ spark triggering depends on both refilling and RyR sensitivity; and (iii) β-adrenergic stimulation influences both processes.
Lysolecithin and acute coronary ligation in thie anaesthetised dog
Authors: R. A RIEMERSMA, B. MICHOROWSIW
Journal: Cardiovascular Research (1983)

Journal Article Lysolecithin and acute coronary ligation in thie anaesthetised dog Get access RUDOLPH A RIEMERSMA, RUDOLPH A RIEMERSMA * From the Cardiovascular Research Unit, University of Edinburgh, Edinburgh, Scotland *Correspondence to: Dr R A Riemersma, Cardiovascular Research Unit, Hugh Robson Building, George Square, Edinburgh, EH8 9XF, Scotland. Present address: Research-Teaching Centre, Academy of Medicine, 04-073 Warsawa, Poland. Search for other works by this author on: Oxford Academic PubMed Google Scholar BOGDAN MICHOROWSIW BOGDAN MICHOROWSIW † From the Cardiovascular Research Unit, University of Edinburgh, Edinburgh, Scotland *Correspondence to: Dr R A Riemersma, Cardiovascular Research Unit, Hugh Robson Building, George Square, Edinburgh, EH8 9XF, Scotland. Present address: Research-Teaching Centre, Academy of Medicine, 04-073 Warsawa, Poland. Search for other works by this author on: Oxford Academic PubMed Google Scholar Cardiovascular Research, Volume 17, Issue 9, September 1983, Pages 505–508, https://doi.org/10.1093/cvr/17.9.505 Published: 01 September 1983
Reliability of health information for the public on the world wide web: systematic survey of advice on managing fever in children at home
Authors: P. Impicciatore, C. Pandolfini, N. Casella, M. Bonati
Journal: BMJ (1997)

<h3>Abstract</h3> <b>Objective:</b> To assess the reliability of healthcare information on the world wide web and therefore how it may help lay people cope with common health problems. <b>Methods:</b> Systematic search by means of two search engines, Yahoo and Excite, of parent oriented web pages relating to home management of feverish children. Reliability of information on the web sites was checked by comparison with published guidelines. <b>Main outcome measures:</b> Minimum temperature of child that should be considered as fever, optimal sites for measuring temperature, pharmacological and physical treatment of fever, conditions that may warrant a doctor9s visit. <b>Results:</b> 41 web pages were retrieved and considered. 28 web pages gave a temperature above which a child is feverish; 26 pages indicated the optimal site for taking temperature, most recommending rectal measurement; 31 of the 34 pages that mentioned drug treatment recommended paracetamol as an antipyretic; 38 pages recommended non-drug measures, most commonly tepid sponging, dressing lightly, and increasing fluid intake; and 36 pages gave some indication of when a doctor should be called. Only four web pages adhered closely to the main recommendations in the guidelines. The largest deviations were in sponging procedures and how to take a child9s temperature, whereas there was a general agreement in the use of paracetamol. <b>Conclusions:</b> Only a few web sites provided complete and accurate information for this common and widely discussed condition. This suggests an urgent need to check public oriented healthcare information on the internet for accuracy, completeness, and consistency. <h3>Key messages</h3> Fever in children is a common problem, and accurate information on home management of feverish children could be useful for parents A systematic search on the world wide web for such parent oriented information retrieved 41 web pages, but only four adhered closely to published guidelines for home management of childhood fever These findings suggest the urgent need to check public oriented healthcare information on the internet for accuracy, completeness, and consistency Information on the internet should not be a substitute for routine care by family doctors
Experimental evidence for the use of CCR2 antagonists in the treatment of type 2 diabetes
Authors: Timothy J. Sullivan, Zhenhua Miao, Bin N. Zhao, Linda S. Ertl, Yu Wang, Antoni Krasinski, Matthew J. Walters, Jay P. Powers, Daniel J. Dairaghi, Trageen Baumgart, Lisa C. Seitz, Robert D. Berahovich, Thomas J. Schall, Juan C. Jaen
Journal: Metabolism (2013)
Adventitial Mast Cells Contribute to Pathogenesis in the Progression of Abdominal Aortic Aneurysm
Authors: Toshihiro Tsuruda, Johji Kato, Kinta Hatakeyama, Kazushi Kojima, Mitsuhiro Yano, Yoshikazu Yano, Kunihide Nakamura, Fukumi Nakamura-Uchiyama, Yoshibumi Matsushima, Takuroh Imamura, Toshio Onitsuka, Yujiro Asada, Yukifumi Nawa, Tanenao Eto, Kazuo Kitamura
Journal: Circulation Research (2008)

Abdominal aortic aneurysm (AAA) is histologically characterized by medial degeneration and various degrees of chronic adventitial inflammation, although the mechanisms for progression of aneurysm are poorly understood. In the present study, we carried out histological study of AAA tissues of patients, and interventional animal and cell culture experiments to investigate a role of mast cells in the pathogenesis of AAA. The number of mast cells was found to increase in the outer media or adventitia of human AAA, showing a positive correlation between the cell number and the AAA diameter. Aneurysmal dilatation of the aorta was seen in the control (+/+) rats following periaortic application of calcium chloride (CaCl2) treatment but not in the mast cell-deficient mutant Ws/Ws rats. The AAA formation was accompanied by accumulation of mast cells, T lymphocytes and by activated matrix metalloproteinase 9, reduced elastin levels and augmented angiogenesis in the aortic tissue, but these changes were much less in the Ws/Ws rats than in the controls. Similarly, mast cells were accumulated and activated at the adventitia of aneurysmal aorta in the apolipoprotein E-deficient mice. The pharmacological intervention with the tranilast, an inhibitor of mast cell degranulation, attenuated AAA development in these rodent models. In the cell culture experiment, a mast cell directly augmented matrix metalloproteinase 9 activity produced by the monocyte/macrophage. Collectively, these data suggest that adventitial mast cells play a critical role in the progression of AAA.
Abstract 2079: Antitumoral activity of INC280 against adult glioblastoma brain tumors xenografts.
Authors: Stephen T. Keir, Martin A. Roskoski, Sabrina Wagner, Ralph Tiedt, Darell D. Bigner, Henry S. Friedman
Journal: Cancer Research (2013)

Abstract INTRODUCTION: INC280 is an oral, highly selective c-Met receptor tyrosine kinase inhibitor. The hepatocyte growth factor (HGF)-c-Met pathway is one of the most frequently dysregulated pathways in human cancers. Aberrant HGF-c-Met signaling has been documented in a wide range of human malignancies. The c-Met pathway can be activated by abnormal HGF and c-Met expression levels, c-Met activating mutations and gene amplifications. At this time, INC280 is in development for the treatment of solid tumors with activation of the c-Met pathway. As a part of this study, we looked at the antitumoral activity of INC280 in adult glioblastoma (GBM) brain tumor xenografts with elevated levels of Met or HGF expression. METHODS: Met expression and copy number was determined by ELISA and qPCR, HGF mRNA by RT-qPCR. Adult GBM tumor xenografts were grown subcutaneously in athymic BALB/c mice. After tumor size reached 200-500 mm3 subcutaneously, groups of 10 mice were randomly treated with either drug vehicle/control or INC280 (10mg/kg BID) PO for 30 days. Tumor responses for subcutaneous xenografts were assessed by tumor growth delay and regression. RESULTS: Based on activation of the c-Met pathway, the following two xenograft lines were selected for treatment with INC280: D-09-0337 MG and D-09-0477 MG. As a single agent, INC280 demonstrated statistically significant (p&amp;lt;0.001) growth delays of 40.23 and 30.13 days in D-09-0337 MG and D-09-0477 MG, respectively. In addition, when treated with INC280, tumors implanted with D-09-0337 MG (10 out of 10) or D-09-0477 MG (4 out of 10) regressed. CONCLUSION: Our results demonstrate the therapeutic efficacy of the inhibition of a c-Met receptor tyrosine kinase in adult brain tumor xenografts with activation of the c-Met pathway. These results warrant further exploration of INC280 in clinical trials for the treatment of adult brain tumor patients with dysregulated proto-oncogene c-Met and its ligand HGF. Citation Format: Stephen T. Keir, Martin A. Roskoski, Sabrina Wagner, Ralph Tiedt, Darell D. Bigner, Henry S. Friedman. Antitumoral activity of INC280 against adult glioblastoma brain tumors xenografts. [abstract]. In: Proceedings of the 104th Annual Meeting of the American Association for Cancer Research; 2013 Apr 6-10; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2013;73(8 Suppl):Abstract nr 2079. doi:10.1158/1538-7445.AM2013-2079
Competition within the early B-cell compartment conditions B-cell reconstitution after hematopoietic stem cell transplantation in nonirradiated recipients
Authors: Allen Liu, Christian A J Vosshenrich, Chantal Lagresle-Peyrou, Michele Malassis-Seris, Christophe Hue, Alain Fischer, James P Di Santo, Marina Cavazzana-Calvo
Journal: Blood (2006)
Maternal-Fetal Disparity in HLA Class II Alloantigens and the Pregnancy-Induced Amelioration of Rheumatoid Arthritis
Authors: J. Lee Nelson, Kathleen A. Hughes, Anajane G. Smith, Brenda B. Nisperos, Ann M. Branchaud, John A. Hansen
Journal: New England Journal of Medicine (1993)

Rheumatoid arthritis frequently remits during pregnancy, for unknown reasons. Since an immune response to paternally inherited fetal HLA can occur during normal pregnancy and since rheumatoid arthritis is an autoimmune disorder with a known HLA class II antigen association, we tested the hypothesis that maternal-fetal disparity in HLA alloantigens might be associated with the pregnancy-induced remission of rheumatoid arthritis.
Acute Clopidogrel Use and Outcomes in Patients With Non–ST-Segment Elevation Acute Coronary Syndromes Undergoing Coronary Artery Bypass Surgery
Authors: Rajendra H. Mehta, Matthew T. Roe, Jyotsna Mulgund, E. Magnus Ohman, Christopher P. Cannon, W. Brian Gibler, Charles V. Pollack, Sidney C. Smith, T. Bruce Ferguson, Eric D. Peterson
Journal: Journal of the American College of Cardiology (2006)
Smoking and periductal mastitis.
Authors: N J Bundred, M S Dover, N Aluwihare, E B Faragher, J M Morrison
Journal: BMJ (1993)

Answers given by 51 asthmatic patients to questions about their use ofmetered dose inhalers No of Question Answer subjects When do you stop using your inhaler?When nothing comes out of inhaler 48 When inhaler floats 3 When do you ask for a repeat prescription When inhaler completely empty 9 ofyour inhaler?When inhaler nearly empty 28 When reserve inhaler started 14 Never without inhaler 15 Have you ever found yourself without an inhaler?J No consequences when without inhaler 3 If so, what were the consequences? 1 Became wheezy when without inhaler 25 Became very wheezy when without inhaler 8 Always 10 Do you always have inhalers in reserve?Usually 28 Often no 13 Would you carry on using this inhaler?*{Yes 51 No ~~~~~~~~~~~~0*Patient handed a salbutamol inhaler that was nearly empty.F (2, 67) = 5 022, p = 0 009).
Cowboys, Camels, and the First Amendment — The FDA's Restrictions on Tobacco Advertising
Authors: George J. Annas
Journal: New England Journal of Medicine (1996)

The Marlboro Man and Joe Camel have become public health enemies number one and two, and removing their familiar faces from the gaze of young people has become a goal of President Bill Clinton and his health care officials.1 The strategy of limiting the exposure of children to tobacco advertisements is based on the fact that almost all regular smokers begin smoking in their teens. This approach is politically possible because most Americans believe that tobacco companies should be prohibited from targeting children in their advertising.Shortly before the 1996 Democratic National Convention, the President announced that he had approved . . .
An Address ON THE DIFFERENTIAL DIAGNOSIS OF SURGICAL DYSPEPSIAS: Delivered before the Finchley Ward of the British Medical Association
Authors: A. J. Walton
Journal: BMJ (1912)

THE surgical lesions giving rise to dyspepsia are not only of relative frequency and of a serious nature, but are very prone to be mistaken for less important conditions; and since they are capable of being relieved only by adequate surgical treatment, I have considered that a discussion of the methods whereby an accurate diagnosis can be arrived at will be of practical interest.The clinical history will in these cases be of the greatest value, and, as Moynihan 11 48 has so clearly pointed out, it alone may be sufficient to indicate the nature and site of the lesion.I shall therefore first draw attentioni to the variations in the symptoms as they occur in gastric ulcer, early gastric carcinoma, duodenal ulcer, gall stones, and some cases of appendicitis, and shall then consider the physical signs which may be present at the same time.
Calcifediol in Chronic Renal Insufficiency-Reply
Authors: Steven L. Teitelbaum, Louis V. Avioli
Journal: JAMA (1976)

We appreciate the comments of Drs Coburn and Norman, particularly as regards the hypercalcemic potential of any analogue of vitamin D, illustrating the great care necessitated in using these compounds. We also concur that the superiority (if any) of one natural or synthetic analogue is yet to be proved, although there are little data in the report from Drs Coburn and Norman's group that 1,25-dihydroxycholecalciferol is effective in reversing the osteomalacic manifestations of uremic bone.<sup>1</sup> Drs Coburn and Norman, however, have missed the point of our report, which is to demonstrate the effectiveness of a vitamin D metabolite prior to 1-hydroxylation in the treatment of uremic osteodystrophy. In this regard, we take issue with the contention that interest in the use of vitamin D analogues in uremia center on bypassing "the necessity for 1-hydroxylation in the kidney." Experimental observations of beneficial effect on the uremic skeleton<sup>2</sup>
The Emergency Medical Services Systems Act of 1973
Authors: John Collins Harvey
Journal: New England Journal of Medicine (1975)

The provisions of this recently enacted national legislation1 are generally unknown to physicians and the public alike. The Act provides for grants2 for planning, initial establishment or expansion of existing systems for emergency medical services for a given geographic area. It also authorizes researches in emergency medical technics. The Act calls for local financial sharing of costs. It mandates participation by nonhealth professionals in the planning and formulation of operating policies, and requires continuing education in emergency medical services technics for all involved personnel; uniquely, it requires public education in the area of emergency medical care. Any system to be . . .
Ligamentous Laxity in Athletes-Reply
Authors: William A. Grana
Journal: JAMA (1979)

The questions raised are the essence of our own questions about this method of testing laxity of the joint. Can testing methods validated in a group of professional athletes be used for the same means in a more general population? In this case our results and those of others support the posture that these tests cannot be used to predict the risk of injury for athletes in secondary schools. To be generally applicable, these tests must be valid in other than the professional athlete—a very special breed of human being. This is precisely the reason we say: "It may be that the results from a group of professional football players cannot be extrapolated to other age groups or levels of performance." As to the value of the tests themselves in determining a loose or tight person, we have some reservation regarding the effect of warm-up and practice on
Serum concentrations of cortisone and cortisol in premature infants
Authors: Michiko Fujitaka, Kazuhiko Jinno, Nobuo Sakura, Kazuo Takata, Takemi Yamasaki, Junsou Inada, Takashi Sakano, Nobuko Horino, Kazuo Kidani, Kazuhiro Ueda
Journal: Metabolism (1997)
Leptin promotes the mobilization of vascular progenitor cells and neovascularization by NOX2-mediated activation of MMP9
Authors: Marco R. Schroeter, Susanne Stein, Nana-Maria Heida, Maren Leifheit-Nestler, I-Fen Cheng, Rajinikanth Gogiraju, Hans Christiansen, Lars S. Maier, Ajay M. Shah, Gerd Hasenfuss, Stavros Konstantinides, Katrin Schäfer
Journal: Cardiovascular Research (2011)

AimsBone marrow (BM) progenitors participate in new vessel formation and endothelial repair. The leptin receptor (ObR) is expressed on hematopoietic cells; however, the effects of leptin on BM progenitor cells and their angiogenic potential are unknown.
(23) Lichen amyloidosus
Authors: R.P. Warin
Journal: British Journal of Dermatology (1977)

Journal Article (23) Lichen amyloidosus Get access R.P. Warin R.P. Warin Bristol Royal Infirmary Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 97, Issue s15, 1 December 1977, Pages 57–58, https://doi.org/10.1111/j.1365-2133.1977.tb14331.x Published: 01 December 1977