tbuckley/cabot-search huggingface dataset:
Retracted: Equilibrative nucleoside transporter (ENT)-1-dependent elevation of extracellular adenosine protects the liver during ischemia and reperfusion
Authors: Michael A. Zimmerman, Eunyoung Tak, Stefan F. Ehrentraut, Maria Kaplan, Antasia Giebler, Tingting Weng, Doo-Sup Choi, Michael R. Blackburn, Igal Kam, Holger K. Eltzschig, Almut Grenz
Journal: Hepatology (2013)

Ischemia and reperfusion-elicited tissue injury contributes to morbidity and mortality of hepatic surgery and during liver transplantation. Previous studies implicated extracellular adenosine signaling in liver protection. Based on the notion that extracellular adenosine signaling is terminated by uptake from the extracellular towards the intracellular compartment by way of equilibrative nucleoside transporters (ENTs), we hypothesized a functional role of ENTs in liver protection from ischemia. During orthotopic liver transplantation in humans, we observed higher expressional levels of ENT1 than ENT2, in conjunction with repression of ENT1 and ENT2 transcript and protein levels following warm ischemia and reperfusion. Treatment with the pharmacologic ENT inhibitor dipyridamole revealed elevations of hepatic adenosine levels and robust liver protection in a murine model of liver ischemia and reperfusion. Studies in gene-targeted mice for Ent1 or Ent2 demonstrated selective protection from liver injury in Ent1(-/-) mice. Treatment with selective adenosine receptor antagonists indicated a contribution of Adora2b receptor signaling in ENT-dependent liver protection.These findings implicate ENT1 in liver protection from ischemia and reperfusion injury and suggest ENT inhibitors may be of benefit in the prevention or treatment of ischemic liver injury.
Differential phosphoprotein profiling by PA-GeLC-MS/MS to define cellular responses to targeted therapies
Authors: Stephen Kron, Kolbrun Kristjansdottir, Ding Wu, Samuel Volchenboum, David Angulo, Don Wolfgeher
Journal: Clinical Cancer Research (2008)

B43  Molecularly targeted cancer therapies such as antibodies and small molecule signal transduction inhibitors have proved extraordinary value both as single agents and adjuncts to conventional cytotoxic therapy. As examples, hormonal blockade slows progression of breast and prostate cancer while kinase inhibitors have found wide use in treating leukemias and solid tumors. Yet, few agents demonstrate the efficacy and/or safety to reach Phase III trials or clinical use, reflecting off-target effects, patient-to-patient variability and other factors.   Clearly, better assays for diagnosis, prediction and monitoring are needed. While simple biomarkers have proved inadequate, molecular signatures that predict tumor sensitivity and report on efficacy or resistance remain to be developed. Multiplexed analysis of gene expression is robust, but targets may be far upstream of transcription. A proteomic approach focused on analysis of signal transduction is an attractive alternative. We have recently developed a straightforward method for definition of global phosphoprotein profiles that may help answer the challenge. Our methodology, dubbed PA-GeLC-MS/MS, involves phosphoprotein affinity purification, separation by SDS-PAGE, LC-MS/MS and informatic analysis. We exploit stable isotope labeling to differentiate phosphoprotein abundance in pairs of samples, allowing direct comparison of controls with cells treated with targeted agents. We have implemented novel informatic tools to exploit high mass accuracy and isotopic labels that enhance speed and reproducibility of protein identification and quantitation.   To validate our approach, we performed phosphoprotein proteome profiling of K562 Ph1+ chronic myelogenous leukemia cells before and after treatment with the Bcr-Abl tyrosine kinase inhibitor imatinib. Phosphoprotein affinity purification led to enrichment of both tyrosine and serine/threonine phosphorylated proteins. LC-MS/MS analysis identified nearly 2000 proteins from a single gel lane with high confidence. Abundance analysis revealed many proteins differentially regulated by imatinib, including several known Bcr-Abl substrates. Toward applying this approach to circulating CML cells, we will compare imatinib with the second generation agents dasatinib and nilotinib and develop signatures for imatinib resistance. Following a similar path, to reveal markers of tamoxifen sensitivity and resistance, we are profiling breast cancer cell lines based on phosphoprotein enrichment of cytoplasmic proteins. We intend to define signatures of cellular signaling that distinguish malignancies and report effects of targeted agents, with the ultimate goal of developing high-throughput assays compatible with drug discovery and clinical testing.
CHEMICAL STUDIES OF THE BLOOD IN HIGH INTESTINAL OBSTRUCTION 1
Authors: George Martin Guest, William DeWitt Andrus
Journal: Journal of Clinical Investigation (1932)

This paper presents an investigation of the effects of experimental high intestinal obstruction in dogs, with particular emphasis on changes observable in the distribution of phosphorus in the blood.The experi- ments were undertaken as a part of a series of studies of phosphorus distribution in the blood of man and experimental animals in a variety of pathologic conditions.In dogs, marked changes of the distribution of phosphorus were observed following pyloric and mid-duodenal obstruc- tion; an attempt is here made to correlate these changes with the varia- tions in the blood electrolytes commonly observed in intestinal obstruc- tion.
Lymphogranuloma Venereum Among Men Who Have Sex with Men --- Netherlands, 2003--2004
Authors: M.J.W. van de Laar, H.M. Götz, O. Zwart, W.I. van der Meijden, J.M. Ossewaarde, H.B. Thio, J.S.A. Fennema, M. Spaargaren, H.J.C. de Vries, S.M. Berman, J.R. Papp, K.A. Workowski
Journal: MMWR Morbidity and Mortality Weekly Report (2004)

Lymphogranuloma venereum (LGV) is a systemic, sexually transmitted disease (STD) caused by a variety of the bacterium Chlamydia trachomatis that rarely occurs in the United States and other industrialized countries; the prevalence of LGV is greatest in Africa, Southeast Asia, Central and South America, and Caribbean countries. However, in the Netherlands, which typically has fewer than five cases a year, as of September 2004, a total of 92 cases of LGV had been confirmed during the preceding 17 months among men who have sex with men (MSM). The first 13 cases, diagnosed during April-November 2003, were reported by local health authorities in Rotterdam in December 2003. An alert was sent to the Early Warning and Reporting System of the European Union and to the European Surveillance of Sexually Transmitted Infections Network (ESSTI). In April 2004, a report was made to CDC, and state and local health departments were alerted. Of the 92 cases confirmed in the Netherlands, 30 occurred during 2003 and 62 during 2004. This report describes the ongoing investigation of the LGV outbreak. Health-care providers should be vigilant for LGV, especially among MSM exposed to persons from Europe, and prepared to diagnose the disease and provide appropriate treatment to patients and their exposed sex partners
Abstract 09: A Community-Based Exercise Intervention Transitions Metabolically Abnormal Obese Adults to a Metabolically Healthy Obese Phenotype
Authors: Lance C Dalleck, Tara B Richardson, Gary P Van Guilder
Journal: Circulation (2014)

Introduction: It has been estimated that 32% of obese adults in the US are metabolically healthy. This subset of individuals, referred to as metabolically healthy but obese (MHO), appear to be more resistant to the adverse cardiometabolic consequences faced by their metabolically abnormal obese (MAO) counterparts. Cross-sectional observations indicate that increased physical activity and higher fitness contribute to the protective metabolic characteristics in this subset of obese individuals. However, to date no study has investigated whether a community-based exercise intervention designed to increase exercise volume and fitness can transition MAO adults to a MHO phenotype. Identifying the therapeutic dose of exercise required to convert a MAO person to metabolically healthy would yield important clinical information for the primary prevention of cardiovascular disease. Hypothesis: We assessed the following hypotheses: (1) community-based exercise training would transition MAO adults to metabolically healthy, and (2) the odds of successful transition to a metabolically healthy phenotype would be larger for obese individuals who [[Unable to Display Character: &amp;#8211;]] (a) performed the highest volume of exercise, and (b) experienced the greatest increase in fitness. Methods: Three-hundred thirty-two healthy adults (190 women, 142 men; aged 28-88 years) engaged in a supervised 14-week community-based exercise program designed to favorably modify cardiovascular disease risk factors. Components of the metabolic syndrome (National Cholesterol Education Program ATP III criteria) were measured before and after the exercise program. Obese (BMI ≥ 30 kg·m 2 ) adults who met 2-4 criteria for metabolic syndrome were classified as metabolically abnormal. Metabolically healthy was defined if obese adults met 0 to 1 criteria for metabolic syndrome. Results: Baseline point prevalence of MAO was 20.5% (N = 68). There was a significant reduction (p&lt;0.05) in point prevalence of MAO to 12.3% by post program as 27/68 individuals (40%) transitioned to MHO. Compared to the lowest quartiles of relative energy expenditure and change in fitness, participants in the highest quartiles were 21.8 (95% CI 4.4[[Unable to Display Character: &amp;#8211;]]108.0; p&lt;0.05) and 8.2 (95% CI 3.1[[Unable to Display Character: &amp;#8211;]]21.6; p&lt;0.05) times more likely to transition from MAO to MHO, respectively. Conclusions: These findings indicate that supervised community exercise can transition MAO adults to a MHO phenotype. MAO adults who engaged in higher volumes of exercise and those who demonstrated greater improvements in fitness were significantly more likely to become metabolically healthy. Importantly, the unfavourable metabolic characteristics of obesity are not irreversible. Community exercise should be considered an effective model for the primary prevention of cardiovascular disease in MAO adults.
Abstract 18833: Annulus Preservation Strategy Improves Late Outcomes in Tetralogy of Fallot: An Anatomical Equivalency Study
Authors: Prisca Pondorfer, Tae-Jin Yun, Michael Cheung, David Ashburn, Cedric Manlhiot, Brian McCrindle, Luc Mertens, Lars Grosse-Wortmann, Andrew Redington, Glen Van Arsdell
Journal: Circulation (2014)

Introduction: Late outcome of repaired TOF is driven by the impact of residual lesions. We shifted strategy from liberal transannular patch (TAP) use to aggressive valve and annulus preservation (AP) hypothesizing that for equivalent anatomy, AP would leave a mixed stenosis regurgitation lesion that would lead to a healthier right ventricle (RV). Methods: Between 1996 and 2002, 185 children underwent TOF repair (median age 7.7 m). A regression equation for predicting annulus preservation, in the AP group, was derived from preoperative anatomic parameters and applied to all. Patients were identified (n=107) that could have had either AP or TAP on the basis of anatomical equivalency (subgroup validation with propensity matching) with 52 having a TAP and 55 having AP. These are the primary study group. Results: Cardiac MRI at mean age 13.1±2.3 yrs (TAP n=28, AP n=23) showed AP was associated with significantly lower indexed RV end diastolic vol (AP: 120±29; TAP: 181±35 mL - Fig. 1), RV end systolic vol (AP: 57±23; TAP: 95±25 mL), RV stroke volume (AP: 64±15; TAP: 86±15 mL), MPA regurgitant fraction (AP: 28±11; TAP: 45±9 %), all p&lt;0.0001, and LV mass (AP: 46±6; TAP: 54±8 gm/m2); p=0.001). Echo RVOT gradient was no different (AP 31 Vs TAP 25 mmHg (p=ns). MRI LVEF (AP: 57±4; TAP: 55±4 %; P=0.031) and RVEF (AP: 54±7; TAP: 48±6 %; p=0.004) was higher after AP. Freedom from surgical reintervention at 15 years was 89.3% (TAP) and 71.7% (AP , P=0.048) (Fig.2) with early reoperation for RVOTO predominating in AP and late pulmonary valve replacement most frequent in TAP. VO2 max for all AP vs TAP was higher in AP (p&lt;0.05). Conclusion: This is the first long-term follow-up study demonstrating that, for equivalent anatomy, an aggressive AP strategy leads to a lower reoperative incidence, less pulmonary insufficiency, smaller indexed RV volumes and better LV function as compared to a standard TAP. Surgical strategy directly impacts ventricular health and should be reflected in practice.
Will Evidence-Based Practice Help Span Gulf Between Medicine and Law?
Authors: C Marwick
Journal: JAMA (2000)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Plastic Surgery of the Nose Including Reconstruction of War Injuries and of Deformities from Neoplastic, Traumatic, Radiation, Congenital, and Other Causes
Authors: James Barrett Brown, Frank McDowell
Journal: JAMA (1952)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
In vitro differentiation of leukemic cells to eosinophils in the presence of interleukin-5 in two cases of acute myeloid leukemia with the translocation (8;21)(q22;q22)
Authors: H Ema, K Kitano, T Suda, Y Sato, K Muroi, M Ohta, M Yoshida, S Sakamoto, M Eguchi, Y Miura
Journal: Blood (1990)
Erratum: Corrigendum: Epigenetic modulation of the renal β-adrenergic–WNK4 pathway in salt-sensitive hypertension
Authors: ShengYu Mu, Tatsuo Shimosawa, Sayoko Ogura, Hong Wang, Yuzaburo Uetake, Fumiko Kawakami-Mori, Takeshi Marumo, Yutaka Yatomi, David S Geller, Hirotoshi Tanaka, Toshiro Fujita
Journal: Nature Medicine (2011)
Myeloid Growth Factors Promote Resistance to Mycobacterial Infection by Curtailing Granuloma Necrosis through Macrophage Replenishment
Authors: Antonio J. Pagán, Chao-Tsung Yang, James Cameron, Laura E. Swaim, Felix Ellett, Graham J. Lieschke, Lalita Ramakrishnan
Journal: Cell Host & Microbe (2015)

The mycobacterial ESX-1 virulence locus accelerates macrophage recruitment to the forming tuberculous granuloma. Newly recruited macrophages phagocytose previously infected apoptotic macrophages to become new bacterial growth niches. Granuloma macrophages can then necrose, releasing mycobacteria into the extracellular milieu, which potentiates their growth even further. Using zebrafish with genetic or pharmacologically induced macrophage deficiencies, we find that global macrophage deficits increase susceptibility to mycobacterial infection by accelerating granuloma necrosis. This is because reduction in the macrophage supply below a critical threshold decreases granuloma macrophage replenishment to the point where apoptotic infected macrophages, failing to get engulfed, necrose. Reducing macrophage demand by removing bacterial ESX-1 offsets the susceptibility of macrophage deficits. Conversely, increasing macrophage supply in wild-type fish by overexpressing myeloid growth factors induces resistance by curtailing necrosis. These findings may explain the susceptibility of humans with mononuclear cytopenias to mycobacterial infections and highlight the therapeutic potential of myeloid growth factors in tuberculosis.
Abstract 13275: The Intermountain Risk Score is a Robust Predictor of Mortality in Patients With Chronic Kidney Disease
Authors: Allen C Rassa, Benjamin D Horne, Raymond McCubrey, Tami L Bair, Joseph B Muhlestein, Donald Morris, Jeffrey L Anderson
Journal: Circulation (2014)

Introduction: Chronic kidney disease (CKD) is a common disorder associated with increased cardiovascular mortality. The Intermountain Risk Score (IMRS) is an electronic risk calculator that utilizes the complete blood count (CBC), basic metabolic panel (BMP), age and sex to predict all-cause mortality. We tested whether IMRS predicts mortality in CKD patients (pts) and is additive to CKD staging. We also tested whether serum phosphate (PO4) or urinary albumin (U-alb)/creatinine (Cr) ratio adds predictive value. Methods: From October 2005 to May 2013, pts with CKD classes IIIa-V seen in the Intermountain Healthcare system with concurrent BMP and CBC tests were followed for survival at 1y (N=3,872) and 5y (N=3,727). Survival analyses were performed for pre-defined IMRS low-, medium- and high-risk groups for combined and separate CKD stages, and for PO4 and U-alb/Cr. Receiver operator characteristic curves were used to generate c-statistics. Results: For pts across the spectrum of CKD, mortality was significantly increased with medium- and high-risk compared to low-risk IMRS categories (1y medium-risk hazard ratio [HR]=4.60 [95% CI: 2.97, 7.12], 1y high-risk: HR=17.6, [11.46, 27.14]; and 5y medium-risk HR=2.5 [1.9, 3.2], 5y high-risk: HR=6.87 [5.44, 8.68], P &lt; 0.001 for all). When adjusted for CKD stage, IMRS remained predictive (1y: HR=3.85 [2.47, 5.99] for medium-risk, HR=12.66 [8.11, 19.76] for high-risk; and 5y: HR=2.30 [1.80, 2.95] for medium-risk, HR=5.55 [4.36, 7.06] for high-risk, P &lt; 0.001 for all). IMRS predicted 1y mortality more efficiently (c=0.735 [se 0.013]) than CKD stage (c=0.660 [se 0.013]); while combining IMRS and CKD stage increased the c-statistic to c=0.759 (se 0.014). PO4 predicted mortality (HR=1.23 [1.15-1.31]) but added only slightly to the IMRS 1y predictive ability (c=0.741 [se 0.016]). U-alb/Cr was not independently associated with mortality (HR=1.01 [0.99-1.01]). Conclusion: IMRS is a strong predictor of mortality in patients with CKD and is robustly complementary to CKD stage in refining risk stratification. Given the universal electronic availability and low cost of CBC and BMP, IMRS may represent a major advance in CKD risk assessment and management.
A carbamazepine trial in chronic, treatment-refractory schizophrenia
Authors: J Sramek, J Herrera, J Costa, C Heh, T Tran-Johnson, G Simpson
Journal: American Journal of Psychiatry (1988)

Carbamazepine was given to 12 chronic, treatment-refractory schizophrenic patients for 5 weeks. No overall change was found, but four patients significantly improved while eight worsened. Given the paucity of successful treatments for refractory schizophrenia, further study of carbamazepine appears warranted.
Placing Malpractice in Perspective
Authors: Nathan Hershey
Journal: Annals of Internal Medicine (1972)

Editorials1 July 1972Placing Malpractice in PerspectiveNATHAN HERSHEYNATHAN HERSHEYSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-77-1-146 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptArticles in the popular press ( 1 ), some of which refer to a "malpractice crisis," have brought the issues of medical malpractice to many consumers of health services. Their reactions to such articles* (some of which are inaccurate and misleading) are almost certainly different from those of most physicians. Consumers may conclude that there is a "malpractice crisis" in the eyes of the medical profession and the insurance industry, precisely because patients who bring legal actions today against physicians are more successful in obtaining awards or settlements than in the past.Consumers read of courts recognizing new legal rules...References1. HALBERTSTAM M: The doctor's new dilemma—"will I be sued?" N.Y. Times Magazine, p. 8, 14 February 1971 Google Scholar2. The malpractice threat: a study of defensive medicine. Duke Law Journal 5:939-993, 1971 Google Scholar3. HERSHEY N: The defensive practice of medicine. Myth or reality. Milbank Mem Fund Q 50:69-97, 1972 CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Department of Public Health Practice Graduate School of Public Health University of Pittsburgh Pittsburgh, Pa.*Television, films, and books also inform (and misinform) the public concerning medical malpractice. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 July 1972Volume 77, Issue 1Page: 146-148KeywordsMedical services ePublished: 1 December 2008 Issue Published: 1 July 1972 PDF downloadLoading ...
Clinical importance of minimal residual disease in childhood acute lymphoblastic leukemia
Authors: Elaine Coustan-Smith, Jose Sancho, Michael L. Hancock, James M. Boyett, Frederick G. Behm, Susana C. Raimondi, John T. Sandlund, Gaston K. Rivera, Jeffrey E. Rubnitz, Raul C. Ribeiro, Ching-Hon Pui, Dario Campana
Journal: Blood (2000)