tbuckley/cabot-search huggingface dataset:
Refusing to provide a prenatal test: can it ever be ethical?
Authors: Paul D Kelly
Journal: BMJ (2006)

Physical activity to prevent obesity in young children Negative outcome or protocol problem?Editor-Although the article by Reilly et al on physical activity to prevent obesity in young children emphasises that adherence to protocol was good, 1 an interview with Reilly on the Today programme (7.20 am, 6 October 2006) cited the difficulty in getting children to increase their activity as much as required-that is, not a negative outcome, but a problem in achieving sufficient increase to make the intervention effective.Which was the case?
Removing Substances from Blood by Affinity Chromatography
Authors: Paul H. Plotz, Paul D. Berk, Bruce F. Scharschmidt, Joyce Kay Gordon, John Vergalla
Journal: Journal of Clinical Investigation (1974)

Substances such as bilirubin that bind tightly to plasma proteins cannot readily be removed from blood. We describe here the use of affinity chromatography as a new approach to the removal of proteinbound metabolites and toxins from blood. Agarose beads were coupled via cyanogen bromide to human serum albumin so as to contain 30-50 mg of albumin/g wet wt. Such beads, when exposed to plasma from a patient with congenital nonhemolytic jaundice labeled with [(14)C]-bilirubin, bound more than 150 mug bilirubin/g of beads. The binding was saturable, concentration-dependent, relatively independent of flow rate, and reversible by elution with plasma, albumin, or 50% (vol/vol) ethanol. The beads could be repeatedly reused without loss of efficiency after ethanol elution and long storage in the cold. Salicylate, cortisol, and taurocholate, which bind weakly to albumin, were retarded by the beads but eluted with neutral buffer. Thyroxine, taurolithocholate, chenodeoxycholate, and digitoxin bound tightly but were eluted with 50% ethanol. Digoxin did not bind at all. When whole blood was passed over agarose-albumin beads, bilirubin was removed, calcium and magnesium fell slightly, but red cells, white cells, platelets, clotting factors, and a variety of electrolytes and proteins were substantially unchanged. Agarose-albumin beads may be useful for removing protein-bound substances from the blood of patients with liver failure, intoxication with protein-bound drugs, or specific metabolic deficits. Furthermore, it may be possible to make useful adsorbents by attaching other proteins to agarose or other polymer beads.
Cutaneous Manifestations of Systemic Disease
Authors: Udo J. Wile
Journal: Annals of Internal Medicine (1932)

Article1 March 1932Cutaneous Manifestations of Systemic DiseaseUDO J. WILE, M.D.UDO J. WILE, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-5-9-1103 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptMore than a half a century has elapsed since cutaneous medicine became established as a recognized special field. The development of specialties in general has come about rather slowly, receiving initiative from the great epochs of modern medical science, notably the rational pathology of the Virchow school and the application to the theory and practice of medicine of the principles of modern bacteriology and immunity.Dermatology may be said in some respects to have had an unfortunate and precipitous birth. It did not develop gradually but was rather abruptly established as a result of the classification of dermatoses based upon... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Ann Arbor, Michigan*Studies and Contributions of the Department of Dermatology and Syphilology, University of Michigan Medical School, service of Dr. Udo J. Wile.†Read at a Stated Meeting of the New York Academy of Medicine, December 3, 1931. Received for publication, December 30, 1931. Nextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byCutaneous MedicineCongenital leucemia 1 March 1932Volume 5, Issue 9Page: 1103-1112KeywordsBacteriologyBirthDermatologyImmunitySkin diseases ePublished: 1 December 2008 Issue Published: 1 March 1932 PDF downloadLoading ...
Abstract 11330: Layer Specific Quanti[[Unable to Display Character: &#64257;]]cation of Myocardial Deformation by Strain Echocardiography May Detect Micro Vascular Obstruction and Hemorrhage in Patients With Acute Myocardial Infarction After Reperfusion
Authors: Xing Sheng Yang, Zhiqing Qiao, Jing Ping Sun, Hang Zhao, Heng Ge, Xuedong Shen, Zheng Li, Changhua Wei, Jun Pu, Ben He, Cheuk-Man Yu
Journal: Circulation (2014)

Background: The myocardial reperfusion injury can paradoxically reduce the beneficial effects of myocardial reperfusion. We sought to detect the reperfusion injury using parameters of layer-specific myocardial deformation in patients with acute myocardial infarction (MI) after intervention therapy. Methods: Two-D speckle tracking echocardiography (2DSTE) was performed in 81 patients (mean age 57±9 years, 76 men) with acute MI after primary percutaneous coronary intervention (PCI). The peak systolic myocardial segmental layer longitudinal (LS) and circumferential (CS) strains were assessed by 2DSTE using an 18-segment model of left ventricle. The micro vascular obstruction (MVO) and intramyocardial haemorrhage (IMH) were determined by contrast-enhanced cardiac magnetic resonance imaging(ceCMR). Results: There were 422/1,458 segments with transmural necrosis in 81 patients. There were 58 patients with MVO and 46 patients with IMH. The amplitudes of myocardial layers LS and CS were significantly decreased in...
Book: Cannabis and Cognitive Functioning
Authors: P. Wilson
Journal: BMJ (1998)

Nadia Solowij Cambridge University Press, £50, pp 290 ISBN 0 521 59114 7 Rating:![Graphic][1]</img>![Graphic][2]</img>![Graphic][3]</img> People who have enjoyed using cannabis describe feelings of mild euphoria, pleasant alterations of perception, relaxation, and increased sociability. Others may experience anxiety, panic, or even psychotic reactions. Cannabis intoxication can produce measurable impairments in concentration and short term memory, difficulties in goal directed activity, slowed reaction times, and altered perceptions of the passage of time. Despite public interest, and consequent generous research funding, evidence for persistent cognitive dysfunction has so far proved elusive. It … [1]: /embed/inline-graphic-1.gif [2]: /embed/inline-graphic-2.gif [3]: /embed/inline-graphic-3.gif
儿童为什么有慢性腹痛,长大后如何?人群队列研究
Authors: Matthew, Hotopf, Siobhan, Carr, Richard, Mayou, Michae, lWadsworth, Simon, Wessely, 王维民
Journal: BMJ (1998)

目的:验证假说——腹痛儿童的父母易焦虑,这些儿童的家庭中躯体疾病发生率较高,他们长大后很多都出现医学上不能解释的症状和精神障碍。设计:人群出生后的队列研究。对照:普通人群。对象:国家监测健康与发育医学研究委员会(MRC)的参
Acute Respiratory Distress Syndrome: A Comprehensive Clinical Approach
Authors: Darryl Y. Sue
Journal: Annals of Internal Medicine (2000)

Medical Writings: Book Notes15 February 2000Acute Respiratory Distress Syndrome: A Comprehensive Clinical ApproachDarryl Y. Sue, MDDarryl Y. Sue, MDHarbor-UCLA Medical Center, Torrance, California. (Sue)Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-132-4-200002150-00027 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail Russell JA, Walley KR, eds. 356 pages. Cambridge, UK: Cambridge Univ Pr; 1999. $49.95. ISBN 0521654106. Order phone 800-872-7423.Field of medicine: Critical care medicine.Format: Softcover book.Audience: Internists, intensivists, and hospitalists who manage critically ill patients; students; and residents.Purpose: To provide a comprehensive clinically oriented handbook on the acute respiratory distress syndrome (ARDS) that includes the pathophysiologic and epidemiologic background needed to improve clinical management.Content: The book focuses on the impact of recent clinical and basic science information and the importance of better understanding the underlying pathophysiology of the lungs, cardiovascular system, and other nonrespiratory systems. ... Author, Article, and Disclosure InformationAffiliations: Harbor-UCLA Medical Center, Torrance, California. (Sue) PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 15 February 2000Volume 132, Issue 4Page: 332KeywordsAcute respiratory distress syndromeCritical careLungsNosocomial infectionsRespiratory systemRespiratory system proceduresSoftware toolsThoraxVentilatorsWeaning ePublished: 15 August 2000 Issue Published: 15 February 2000 Copyright & PermissionsCopyright © 2000 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Exhibition: Artists for Medecins du Monde
Authors: R. Harling
Journal: BMJ (1999)

Hart Gallery, London, 25 May to 1 June. Moving to Munich and Milan

Medecins du Monde provides health care to the victims of war, natural disasters, or political repression, treating both physical wounds and psychological trauma. International volunteers, including about 700 medical staff, carry out relief programmes all over the world. They are also involved in domestic projects, providing health care for socially disadvantaged people in France. As an independent organisation funded largely through charitable donations, Medecins du Monde is able to help “forgotten populations” who have often been overlooked by the media and “official” sources of humanitarian aid.



© Mimmo Paladino, Sans titre



Relief programmes include emergency projects to bring immediate aid, rehabilitation projects to help restore sanitary conditions, and long term projects to mitigate the effects of …
Hem Asit Hem de Zayıf Asidik Gastroözofageal Reflü Tanısında Birleşik Çok Kanallı Lümen İçi Empedans ve Özofagus pH Testinin Tek Başına pH ile Karşılaştırılması
Authors: Amine Hila, Amit Agrawal, ve Donald O. Castell
Journal: Clinical Gastroenterology and Hepatology (2007)
Reliability of EP3OS symptom criteria and nasal endoscopy in the assessment of chronic rhinosinusitis – a GA<sup>2</sup>LEN study
Authors: P. Tomassen, R. B. Newson, R. Hoffmans, J. Lötvall, L. O. Cardell, M. Gunnbjörnsdóttir, T. Thilsing, P. Matricardi, U. Krämer, J. S. Makowska, G. Brozek, M. Gjomarkaj, P. Howarth, C. Loureiro, E. Toskala, W. Fokkens, C. Bachert, P. Burney, D. Jarvis
Journal: Allergy (2010)

To cite this article: Tomassen P, Newson RB, Hoffmans R, Lötvall J, Cardell LO, Gunnbjörnsdóttir M, Thilsing T, Matricardi P, Krämer U, Makowska JS, Brozek G, Gjomarkaj M, Howarth P, Loureiro C, Toskala E, Fokkens W, Bachert C, Burney P, Jarvis D. Reliability of EP3OS symptom criteria and nasal endoscopy in the assessment of chronic rhinosinusitis – a GA 2 LEN study. Allergy 2011; 66 : 556–561. Abstract Background: The European Position Paper on Rhinosinusitis and Nasal Polyps (EP3OS) incorporates symptomatic, endoscopic, and radiologic criteria in the clinical diagnosis of chronic rhinosinusitis (CRS), while in epidemiological studies, the definition is based on symptoms only. We aimed to assess the reliability and validity of a symptom‐based definition of CRS using data from the GA 2 LEN European survey. Methods: On two separate occasions, 1700 subjects from 11 centers provided information on symptoms of CRS, allergic rhinitis, and asthma. CRS was defined by the epidemiological EP3OS symptom criteria. The difference in prevalence of CRS between two study points, the standardized absolute repeatability, and the chance‐corrected repeatability (kappa) were determined. In two centers, 342 participants underwent nasal endoscopy. The association of symptom‐based CRS with endoscopy and self‐reported doctor‐diagnosed CRS was assessed. Results: There was a decrease in prevalence of CRS between the two study phases, and this was consistent across all centers (−3.0%, 95% CI: −5.0 to −1.0%, I 2 = 0). There was fair to moderate agreement between the two occasions (kappa = 39.6). Symptom‐based CRS was significantly associated with positive endoscopy in nonallergic subjects, and with self‐reported doctor‐diagnosed CRS in all subjects, irrespective of the presence of allergic rhinitis. Conclusion: Our findings suggest that a symptom‐based definition of CRS, according to the epidemiological part of the EP3OS criteria, has a moderate reliability over time, is stable between study centers, is not influenced by the presence of allergic rhinitis, and is suitable for the assessment of geographic variation in prevalence of CRS.
Exophthalmos in Cushing's Syndrome
Authors: D. C. Morgan, A. S. Mason
Journal: BMJ (1958)

DiscussionThe nephrotic syndrome in children is a fluctuating condition.It is characterized by episodes of exacerbation of proteinuria and oedema.Some children remit spon- taneously, losing oedema and proteinuria permanently.Others continue to pass protein, without impairment of renal function, for long periods.A small proportion die of renal and cardiac failure or other causes.Absence of proteinuria for many months does not preclude a relapse.This makes it impossible to evaluate the results of treatment over short periods.In two of our cases moderate doses of cortisone and prednisone did not affect the proteinuria, while a course of prednisolone produced a marked reduction.As Arneil (1956) and Lennard-Jones (1957) have also shown, predni- solone is the only form of treatment that consistently reduces or abolishes proteinuria in children.Proteinuria may recur many months after successful prednisolone treat- ment-as occurred in two of our children; however, these children responded to a further course.It is suggested that prolonged treatment with small doses of prednisolonefor example, 5 mg. on alternate days-may prevent relapse. SummarySix cases of the nephrotic syndrome in children have been treated with large doses of prednisolone and followed for periods of up to 18 months.Five cases lost their proteinuria, and three of these are protein-free at 6, 15, and 18 months after treatment.Two developed proteinuria and oedema after 3 and 15 months.Both were treated again with a course of prednisolone, with disappearance of oedema and reduction in proteinuria.One further case has continued to pass a decreased amount of protein, which was further decreased after another course of prednisolone.ADDENDUM, A ugust, 1958.-SinceOctober, 1957, three of ten children-D.C., S. T., and T. J.-have had no relapses.P. M. and L. L., when last seen, some months ago, were also well.K. G. has had two more relapses ; each has responded to further short courses of prednisolone (0.5 g. in two weeks).Two other cases have been treated and fol- lowed up for nine and six months respectively.Each re- sponded to the initial course, and was kept on a maintenance dose.One of these had to be readmitted six months after bis initial course, but responded to a short course of pred- nisolone (0.5 g. in two weeks).The latter remains well, but continues to have proteinuria, despite maintenance therapy.
“Braking” the Cycle of Resistance in Endocrine Therapy for Breast Cancer
Authors: Angela DeMichele, Lewis A. Chodosh
Journal: Clinical Cancer Research (2015)

Endocrine resistance leads to recurrence and death from breast cancer. Animal models of endocrine resistance enable preclinical identification of efficacious therapeutic combinations and further our understanding of resistance. This strategy provides new insights into optimally targeting interactions between estrogen receptor (ESR-1) activity and the cell cycle by CDK4/6 inhibitors. See related article by Wardell et al., p. 5121.
IOM Points to Need for More Research, Regulation in Alternative Medicine
Authors: Rebecca Voelker
Journal: JAMA (2005)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
THE ACCELERATION AND INHIBITION OF MIGRATION OF HUMAN LEUCOCYTES IN VITRO BY PLASMA PROTEIN FRACTIONS
Authors: Melvin M. Ketchel, Cutting B. Favour
Journal: The Journal of Experimental Medicine (1955)

A new method is described for the quantitative study of leucocyte migration. Blood drawn into a capillary tube is centrifuged, forming a buffy coat. The migration of the leucocytes from the buffy coat into the plasma is measured by means of an ocular micrometer. While there is a great deal of variation from one normal individual to another in the migration rates of leucocytes those of each individual show relatively little variation in migration from day to day (Table I). In all cases of illness studied, the average migration rates fall within the normal range, but there was a wider variation in the day to day migration rate than obtains in normal healthy individuals (Tables II and III). From experiments in which the cells with typically "slow" and "fast" migration rates were tested in both the "slow" and "fast" plasmas, it could be concluded that while the cells invariably have some influence on the migration rate, the major factors influencing leucocyte migration reside in the plasma (Table V). Experiments in which the plasma proteins were fractionated according to the method of Lever et al. indicated the presence of a system of proteins which regulate leucocyte migration. A heat-labile (56 degrees C. for 30 minutes) component of fraction II was able to accelerate leucocyte migration, while fraction III acted as an inhibitor (Tables IX and X).
Patients' perceptions of entitlement to time in general practice consultations for depression: qualitative study * Commentary: Managing time appropriately in primary care
Authors: K. Pollock
Journal: BMJ (2002)

# Patients' perceptions of entitlement to time in general practice consultations for depression: qualitative study {#article-title-2} Objective :: To investigate patients' perceptions of entitlement to time in general practice consultations for depression. Design :: Qualitative study based on interviews with patients with mild to moderate depression. Setting :: Eight general practices in the West Midlands and the regional membership of the Depression Alliance. Participants :: 32 general practice patients and 30 respondents from the Depression Alliance. Results: : An intense sense of time pressure and a self imposed rationing of time in consultations were key concerns among the interviewees. Anxiety about time affected patients' freedom to talk about their problems. Patients took upon themselves part of the responsibility for managing time in the consultation to relieve the burden they perceived their doctors to be working under. Respondents' accounts often showed a mismatch between their own sense of time entitlement and the doctors' capacity to respond flexibly and constructively in offering extended consultation time when this was necessary. Patients valued time to talk and would often have liked more, but they did not necessarily associate length of consultation with quality. The impression doctors gave in handling time in consultations sent strong messages about legitimising the patients' illness and their decision to consult. Conclusions :: Patients' self imposed restraint in taking up doctors' time has important consequences for the recognition and treatment of depression. Doctors need to have a greater awareness of patients' anxieties about time and should move to allay such anxieties by pre-emptive reassurance and reinforcing patients' sense of entitlement to time. Far from acting as "consumers," patients voluntarily assume responsibility for conserving scarce resources in a health service that they regard as a collective rather than a personal resource. # Commentary: Managing time appropriately in primary care {#article-title-24}
Biomass smoke extract increases fibronectin and perlecan release from human lung fibroblasts
Authors: Brian Oliver, Janette Burgess, Judy Black, David Krimmer
Journal: European Respiratory Journal (2011)

Introduction: Approximately 50% of deaths from chronic obstructive pulmonary disease (COPD) in developing countries have resulted from repeated exposure to burning biomass, such as is used in household cooking. Biomass induced COPD has been reported to be associated with a more fibrotic phenotype than cigarette smoke induced COPD. We aimed to investigate if biomass smoke induced extracellular matrix (ECM) protein production from primary human lung cells in vitro.

Methods: Primary human lung fibroblasts were stimulated for up to 72 hours with increasing concentrations of biomass smoke extract (BME) or cigarette smoke extract (CSE) as a comparison. Cells were lysed and deposition of ECM proteins were assessed using ELISA. Activation of intracellular signaling molecules was analysed using western blotting. Release of interleukin (IL)-8 into the supernatant was analysed using capture ELISA. Cell viability was assessed using manual cell counts and a commercially available MTT assay.

Results: Deposition of the ECM proteins perlecan and fibronectin was upregulated by both 5% CSE and 1% BME. 1%, 5%, 10% and 20% BME and 5% CSE significantly upregulated the phosphorylation of ERK1 and ERK2 following 30 minutes exposure and these remained elevated to 24 hours exposure. Release of IL-8 in the supernatant was increased by 5% CSE and 1% BME. Exposure to concentrations of BME >10% caused significant decreases in cell viability.

Conclusion: BME has similar effects to CSE in vitro and has the capacity to directly induce fibrosis by upregulating production of ECM proteins. The mechanisms by which both biomass and cigarette smoke exposure cause lung damage may be similar.