Brucella melitensis Hepatitis: The Absence of Granulomas
Authors: EDWARD J. YOUNG
Journal: Annals of Internal Medicine (1979)

Brief Reports1 September 1979Brucella melitensis Hepatitis: The Absence of GranulomasEDWARD J. YOUNG, M.D.EDWARD J. YOUNG, M.D.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-91-3-414 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptAlthough granulomas are considered to be the characteristic finding in the liver in brucellosis (1), this association has only been well documented in the case of infection due to Brucella abortus (2-7). Almost no information has appeared in the English literature on the histologic changes in the liver during human infection with Brucella melitensis, a species known to produce more fulminant disease than B. abortus (4). We wish to call attention to the different histologic picture that characterizes hepatic involvement in infection due to B. melitensis.Seven patients seen between 1971 and 1978 with blood-culture-proven brucellosis who underwent percutaneous liver...References1. KLATSKIN G. Hepatitis associated with systemic infections. In: SCHIFF L, ed. Diseases of the Liver. 3rd ed. Philadelphia: J. B. Lippincott Co. 1969:607-8. Google Scholar2. FABYAN M. A contribution to the pathogenesis of Br. abortus, Bang, II. J Med Res. 1912;26:441-87. MedlineGoogle Scholar3. SPINKHOFFBAUERWALKERGREEN WWWR. Histopathology of the liver in human brucellosis. J Lab Clin Med. 1949;34:40-58. MedlineGoogle Scholar4. SPINK W. The Nature of Brucellosis. Minneapolis: University of Minnesota Press; 1956. Google Scholar5. KLATSKINYESNER GR. Hepatic manifestations of sarcoidosis and other granulomatous diseases. Yale J Biol Med. 1950;23:207-48. MedlineGoogle Scholar6. MCCOLLOUGHEISELE NC. Brucella hepatitis leading to cirrhosis of the liver. Arch Intern Med. 1951;88:793-802. CrossrefGoogle Scholar7. JOSKEFINCKH RE. Hepatic changes in human brucellosis. Med J Aust. 1955;1:266-9. CrossrefGoogle Scholar8. SHARP W. Pathology of undulant fever. Arch Pathol. 1934;18:72-108. Google Scholar9. SPRUNTMCBRYDE DA. Morbid anatomic changes in cases of brucella infection in man: with report of a necropsy. Arch Pathol. 1936;21:217-26. Google Scholar10. YOUNGSUVANNOPARRAT EU. Brucellosis outbreak attributed to ingestion of unpasteurized goat cheese: clinical features. Arch Intern Med. 1975;135:240-3. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. 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A clinical and pathological study of 40 casesThe Measurement of Serum Alkaline Phosphatase in Clinical MedicineBrucella HepatitisEDWARD J. YOUNG, M.D.Hepatic Granulomas in BrucellosisM. BRUGUERA, M.D., F. CERVANTES, M.D.Granulomas in Brucella melitensis InfectionHEIN G. M. JORDANS, M.D., KEES D. DE BRUIN, M.D.Comparison of Brucella abortus and Brucella melitensis infections of mice and their effect on acquired cellular resistance 1 September 1979Volume 91, Issue 3Page: 414-415KeywordsBrucellaBrucellosisGranulomasHepatitisInfectious diseasesInfectious hepatitisLiverLiver diseases Issue Published: 1 September 1979 PDF DownloadLoading ...