tbuckley/cabot-search huggingface dataset:
Abstract 15421: Central Hemodynamic Response to Oral Glucose Loading Are Blunted in Patients with Impaired Glucose Tolerance or Diabetes
Authors: Tadanao Higaki, Satoshi Kurisu, Noriaki Watanabe, Hiroki Ikenaga, Takashi Shimonaga, Takatoshi Iwasaki, Ken Ishibashi, Yukihiro Fukuda, Yasuki Kihara
Journal: Circulation (2014)

Introduction: Impaired glucose tolerance (IGT) as well as diabetes is associated with the development of cardiovascular disease. We tested the hypothesis that central hemodynamic responses to oral glucose loading were different according to the status of glucose tolerance. Methods: This study enrolled 89 patients with known or suspected coronary artery disease who underwent 75g oral glucose tolerance test (OGTT). Augmentation index (AIx) and central systolic blood pressure (cSBP) were measured using radial applanation tonometry (Omron, HEM 9000-AI) at fasting, and 1, 2 hours after oral glucose loading. Results: In overall patients, oral glucose loading increased pulse rate (60.0 ± 10.4 to 64.7 ± 11.9 bpm, p&lt;0.001), and decreased AIx normalized to a heart rate of 75 bpm (AIx@75) (81.6 ± 13.9 to 74.5 ± 14.1 %, p&lt;0.001) and cSBP (114.7 ± 22.2 to 108.6 ± 21.3 mmHg, p&lt;0.001) at 2h. OGTT identified normal glucose tolerance (NGT) in 40 patients, IGT in 36 patients and diabetes in 13 patients. Decrease in AIx@75 during OGTT was blunted in IGT as well as diabetes patients compared to NGT patients. Decrease in cSBP during OGTT was blunted in IGT patients than NGT patients, and no significant decrease was found in diabetes patients. Conclusions: Our data suggested that central hemodynamic responses to oral glucose loading were blunted in patients with impaired glucose tolerance or diabetes. This blunted fluctuation might be associated with adverse outcome in patients with IGT or diabetes through persistently high levels of AIx and cSBP.
Banning Suspect Supplements
Authors: Tracy Hampton
Journal: JAMA (2004)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Estimation of Purkinje trees from electro-anatomical mapping of the left ventricle using minimal cost geodesics
Authors: Rubén Cárdenes, Rafael Sebastian, David Soto-Iglesias, Antonio Berruezo, Oscar Camara
Journal: Medical Image Analysis (2015)

The electrical activation of the heart is a complex physiological process that is essential for the understanding of several cardiac dysfunctions, such as ventricular tachycardia (VT). Nowadays, patient-specific activation times on ventricular chambers can be estimated from electro-anatomical maps, providing crucial information to clinicians for guiding cardiac radio-frequency ablation treatment. However, some relevant electrical pathways such as those of the Purkinje system are very difficult to interpret from these maps due to sparsity of data and the limited spatial resolution of the system. We present here a novel method to estimate these fast electrical pathways from the local activations maps (LATs) obtained from electro-anatomical maps. The location of Purkinje-myocardial junctions (PMJs) is estimated considering them as critical points of a distance map defined by the activation maps, and then minimal cost geodesic paths are computed on the ventricular surface between the detected junctions. Experiments to validate the proposed method have been carried out in simplified and realistic simulated data, showing good performance on recovering the main characteristics of simulated Purkinje networks (e.g. PMJs). A feasibility study with real cases of fascicular VT was also performed, showing promising results.
Abstract 10905: A Simple Clinical Prognostication Score Can Predict the Long-Term Prognoses of the Patients with Out-Of-Hospital Cardiac Arrests in Relatively Younger Age
Authors: Shoko Ishikawa, Shinichi Niwano, Ryuta Imaki, Ichiro Takeuchi, Wataru Irie, Kazui Soma, Katsuyoshi Kurihara, Tohru Izumi
Journal: Circulation (2011)

Background: Sudden cardiac death is a serious problem in public health and it affects >110,000 people /year in Japan. However, overall survival rate of out-of-hospital cardiac arrests (OHCAs) is still low (6.3%) and predicting factors of OHCAs are unclear. We retrospectively analyzed the clinical factors of patients with OHCAs to evaluate the prognostication score for prediction of the long-term prognoses by dividing their age. Methods and Results: We analyzed 750 consecutive patients of OHCAs with internal cause (July/2008-June/2010). They were divided into 2 groups by the age of 70 (<70 [n=293], ≥70 [n=457]) and the clinical parameters were compared between survivors and non-survivors. In the age of <70, 1 month survivors and patients with good neurological outcome were 34 and 25. The multivariable analysis exhibited 9 independent predicting factors;1) public space where the cardiac arrests were happened (odds rate [OR]:8.0, 95%confidence interval[CI]:1.7-50.2), 2) bystander cardiopulmonary resuscitatio...
Abstract 13248: DPP-4 Inhibition Reduces Atherosclerosis by Priming Monocytes into Alternative M2 Macrophages
Authors: Christoph Brenner, Wolfgang M Franz, Sarah Kuehlenthal, Kira Kuschnerus, Friederike Remm, Hans D Theiss, Ulf Landmesser, Nicolle Krankel
Journal: Circulation (2014)

Introduction: Major parts of the population in the western world are suffering from atherosclerotic diseases like coronary and peripheral artery disease or stroke. Interventional and pharmacological therapies at present focus on the treatment of vascular stenoses, secondary prophylaxis or reduction of cardiovascular risk factors. Hypothesis: In this project, we want to establish the pharmacological inhibition of DPP4 as a new therapeutic concept focussing on macrophage polarization during development of atherosclerosis. Methods: Non-diabetic ApoE-/- mice were treated with normal diet or high fat diet for three months to induce arterial atherosclerotic lesion formation. The descending aorta was stained using Oil-Red-O to quantify atherosclerotic lesions. In parallel mice were treated with Sitagliptin or placebo. Macrophage subtype content (M1, M2) in the aortic wall was quantified using FACS. Results: Mice on high fat diet treated with Sitagliptin showed a dramatic reduction in atherosclerotic lesion formation in contrast to placebo treated animals. Regarding total macrophage content in the vascular wall we could not detect a difference between the treatment groups. However, the number of protective M2 macrophages was more than tripled in the gliptin-treated animals. Moreover, the number of mural M2 macrophages inversely correlated with the aortic plaque burden. In further analyses we could demonstrate that Sitagliptin favoured macrophage polarization to alternatively activated M2 macrophages via the CXCR4-signaling pathway. Conclusions: We demonstrated that long-term Sitagliptin treatment in ApoE-/- animals on high fat diet can successfully inhibit atherosclerotic lesion formation via induction of macrophage polarization to the protective M2 phenotype. Due to the promising results of this study we are currently planning to transfer the underlying therapeutical concept into a randomized clinical trial.
STANDARDS OF PRACTICE OF INTERNAL MEDICINE: METHODS OF JUDGING ITS QUALITY IN HOSPITALS
Authors: A R COLWELL, G K FENN
Journal: Annals of Internal Medicine (1959)

Editorial1 October 1959STANDARDS OF PRACTICE OF INTERNAL MEDICINE: METHODS OF JUDGING ITS QUALITY IN HOSPITALSARTHUR R. COLWELL SR., M.D., GEORGE KARL FENN, M.D.ARTHUR R. COLWELL SR., M.D.Search for more papers by this author, GEORGE KARL FENN, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-51-4-821 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptGeneral interest in evaluating the quality of medical performance in the hospitals of this country has increased significantly during the last decade or so. Among the reasons for this are a fourfold increase in the number of hospital admissions during the last 30 years (table 1), growing initiative by various medical organizations, and availability of federal funds for hospital construction and research project grants.Appraisal of the quality of medical practice must be done by physicians, of course. With increasing specialization each group must judge (or develop methods for others to judge) the performance of their colleagues. The pioneering efforts...1 FellowsZinkBarnwellFauberPeck WWLAJBJECP: Report of the Committee on Measurement of the Quality of Medical Care, Department of Medicine and Surgery, Veterans Administration, Washington 25, D. C., April, 1959. Google Scholar2 Blankenhorn MA: Editorial: Standards of practice of internal medicine and methods of assessing the quality of practice in hospitals, Ann. Int. Med. 47: 367-374 (Aug.) 1957. LinkGoogle Scholar3 Fenn GK: Editorial: Progress report, Committee for the Study of Hospital Standards in Medicine, Ann. Int. Med. 49: 959-965 (Oct.) 1958. LinkGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: 122 S. Michigan Ave. Chicago c/o Dr. Fenn*Report of the Committee for the Study of Hospital Standards in Medicine, supported by grant W-79 to the American College of Physicians by the Division of Hospital and Medical Facilities, National Institutes of Health, U.S.P.H.S. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byThe quality of medical care: Techniques and investigation in the outpatient clinic 1 October 1959Volume 51, Issue 4Page: 821-832KeywordsHospital medicineResearch grants ePublished: 1 December 2008 Issue Published: 1 October 1959 PDF downloadLoading ...
Symptomatic Efficacy of Etanercept and Its Effects on Objective Signs of Inflammation in Early Nonradiographic Axial Spondyloarthritis: A Multicenter, Randomized, Double‐Blind, Placebo‐Controlled Trial
Authors: Maxime Dougados, Désirée van der Heijde, Joachim Sieper, Jürgen Braun, Walter P. Maksymowych, Gustavo Citera, Corinne Miceli‐Richard, James Cheng‐Chung Wei, Ron Pedersen, Randi Bonin, Mahboob U. Rahman, Isabelle Logeart, Joseph Wajdula, Andrew S. Koenig, Bonnie Vlahos, Daniel Alvarez, Jack F. Bukowski
Journal: Arthritis & Rheumatology (2014)

To assess the efficacy of etanercept in the treatment of early active nonsteroidal antiinflammatory drug (NSAID)-refractory nonradiographic axial spondyloarthritis (SpA).The study population consisted of patients who met the Assessment of SpondyloArthritis international Society (ASAS) classification criteria for axial SpA but not the modified New York radiographic criteria for ankylosing spondylitis (as assessed by a radiologist at the central trial site), had a symptom duration of >3 months but <5 years, had a score of ≥4 on the Bath Ankylosing Spondylitis Disease Activity Index, and had been treated unsuccessfully with ≥2 NSAIDs. Patients were randomized to receive etanercept 50 mg/week or placebo and continued background NSAID treatment for 12 weeks (double-blind study); during the subsequent open-label period, all patients received etanercept 50 mg/week. The primary study end point was meeting the ASAS criteria for 40% improvement (ASAS40) at week 12. Magnetic resonance imaging (MRI) of the sacroiliac joints and spine was performed at baseline and week 12.One hundred six patients were randomized to the etanercept group and 109 to the placebo group. Of the 215 patients, the mean ± SD age at baseline was 32.0 ± 7.8 years, 154 (72%) were HLA-B27 positive, and 174 (81%) had MRI-confirmed sacroiliitis. At 12 weeks, the proportion of patients with improvement according to the ASAS40 was significantly higher in the etanercept group than in the placebo group (34 of 105 [32%] versus 17 of 108 [16%]; P = 0.006). Patients who received etanercept exhibited a greater reduction in MRI-based scores for sacroiliac joint inflammation (-46.9% versus -10.9%; P < 0.001) and spinal inflammation (-45.4% versus -33.4%; P = 0.04) compared with placebo-treated patients at week 12. Post hoc analyses suggested a possible association between higher baseline C-reactive protein levels or MRI sacroiliac joint inflammation scores and higher rates of ASAS40 response to etanercept. At week 24, patients in the placebo group who had switched to etanercept at 12 weeks exhibited improvement similar to that observed in patients who had received etanercept for 24 weeks.In patients with nonradiographic axial SpA, etanercept treatment was associated with rapid, significant improvement in symptomatic disease activity, function, and systemic and skeletal inflammation over 12 weeks; clinical/functional improvement was sustained over 24 weeks.
1055. Anterograde Delivery of Gene Product by rAAV5 Vectors
Authors: Kevin D. Foust, Ronald J. Mandel, Paul J. Reier, Terence R. Flotte
Journal: Molecular Therapy (2004)

Neurodegenerative diseases such as Spinal Muscular Atrophy (SMA) and Amyotrophic Lateral Sclerosis (ALS) are characterized by a loss of the lower motor neurons in the spinal cord. Gene therapy is a possible treatment for these diseases. One promising approach is the use of multiple injections of recombinant adeno-associated virus to deliver secreted trophic factors to spinal motor neurons (Kaspar, et al 2003). However the relationship between the upper and lower motor neurons can potentially be utilized to deliver trophic factors to large areas of the spinal cord via a single intracerebral injection. In this study we have demonstrated an alternative approach and have capitalized on the anterograde transport of rAAV derived proteins. A single injection of rAAV5 GFP into the red nucleus of normal mice produced GFP positive fibers in the cortex as well as cervical, thoracic and lumbar levels of the spinal cord. GFP positive axonal projections appeared in both the ventral and lateral rubrospinal tracts with high efficiency. Transgene expression was observed for six weeks after injection. Based on these results, delivery of a transgene encoding a secreted trophic factor such as IGF1 or GDNF to a large portion of the spinal cord may be possible after bilateral injections into the red nucleus. Future directions include delivery of rAAV5 GDNF or IGF1 to the red nucleus of normal and diseased animals to measure protein levels along the spinal cord and investigate the therapeutic effect of this novel gene delivery route.
983. Human Derived Dual Reporter/Suicide Gene System for Simultaneous Pet Imaging of Independent Molecular-Biological Processes In Vivo
Authors: Vilia Tourkova, Malgorzata Dabrovska, Michael Doubrovin, Inna Serganova, Jelena Vider, Tatiana Beresten, Shangive Cai, Ronald Finn, Juri Gelovani Tjuvajev, Vladimir Ponomarev
Journal: Molecular Therapy (2004)
Abstract 13037: Tenascin-c Modulates Inflammatory Response and Aggravate Ventricular Remodeling After Myocardial Infarction in Mice Model
Authors: Taizo Kimura, Akira Sato, Kazuko Tajiri, Wang Zeng, Satoshi Sakai, Toshimichi Yoshida, Michiaki Hiroe, Kyoko I Yoshida, Kazutaka Aonuma
Journal: Circulation (2014)

Tenascin-C (TN-C), an extracellular matrix glycoprotein, transiently appeared in myocardial tissue after acute myocardial infarction (AMI). We have previously reported that AMI patients with higher serum TN-C levels had worse long-term prognosis, suggesting TN-C may play important roles during the development of ventricular remodeling. However, the biological function of TN-C in ventricular remodeling is not fully understood. In this study, using TN-C knock-out(KO) mice, we investigated the effects of TN-C on LV remodeling and the biological function of TN-C during the acute phase of inflammatory responses after myocardial infarction. The 8 to 10 weeks old male wild type (WT) and TN-C knock-out (KO) mice were divided into 4 groups of WT+Sham, KO+Sham, WT+MI and KO+MI. Mice 12 weeks post-MI, the survival rate of both WT+MI (48.3%,14 of 29 mice) and KO+MI (55.6%,15 of 27 mice) groups had no significant difference. However, TN-C KO group had the better cardiac function than WT had (LVEF, 19.02±6.31% vs 10.63±4.43%; p&lt;0.001). Interstitial fibrosis at border area was significantly increased in the WT +MI group to compare with that of KO+MI, whereas the extent of fibrosis in the remote area revealed no significant difference between the two groups. By RT-PCR analysis, WT+MI group showed significantly higher expression of atrial natriuretic peptide at the border including infarcted areas than that of KO+MI at chronic MI phase. At acute phase, fluorescence activated cell sorting analysis showed that ratio of CD45+, CD11b+, Ly6c high pro-inflammatory monocyte were significantly decreased, whereas CD45+, F4/80+, CD206+, anti-inflammatory M2 macrophage were significantly increased in KO+MI compared with WT+MI group 7 days after MI. RT-PCR analysis showed that the expression of IL-10, an anti-inflammatory cytokine, was significantly higher in KO+MI than WT+MI. These findings suggest, TN-C aggravates the deterioration of LV function due to MI partly by modulating inflammation at acute phase.
A foodborne outbreak of Salmonella Bareilly in the United Kingdom, 2010
Authors: P Cleary, L Browning, J Coia, J Cowden, A Fox, J Kearney, C Lane, H Mather, C Quigley, Q Syed, D Tubin-Delic, Collective on behalf of the outbreak control team
Journal: Eurosurveillance (2010)

We report the preliminary findings of the investigation of an outbreak of foodborne Salmonella Bareilly. Between August and November 2010, there were 231 laboratory-confirmed reports of S. Bareilly in the United Kingdom. A case–control study showed that consumption of bean sprouts was significantly associated with illness. The investigation concluded that raising public awareness to ensure the correct preparation of raw bean sprouts during cooking was the principal means of preventing further cases.
Abstract 18478: Deletion of E2f1 Promotes Bone-marrow Progenitor Cell Differentiation and Ischemic Cardiac Repair
Authors: Shiyue Xu, Tianjiao Sun, Jun Tao, Gangjian Qin
Journal: Circulation (2014)

Background:  We have previously shown that knockout of E2F1 in mice enhances angiogenesis following induction of hind limb ischemia. Recent studies suggest that suppression of E2F1 enhances oxidative phosphorylation in a variety of cell types. Since an increase in oxidative phosphorylation in stem/progenitor cells is often associated with cell differentiation, we hypothesize that E2F1-deficiency may promote bone marrow (BM) progenitor cell differentiation thereby impact on ischemic cardiac repair.   Methods and Results:  We cultured bone marrow (BM) Lin- progenitor cells under hypoxic and normxic conditions for 24 h, then measured the expression of metabolism associated genes and evaluated cell proliferation and differentiation. We also performed adoptive BM transplantation to reconstitute BM of WT mice with E2F1-/- or WT BM, followed by surgical induction of myocardial infarction (MI), to compare the role of BM E2F1 in the cardiac repair in vivo. Notably, we found that the expression levels of pyruvate dehydrogenase kinase (PDK)-4 and PDK2, two critical inhibitors of mitochondrial oxidative phosphorylation, in the E2F1-/- BM Lin- progenitor cells is markedly lower than those in WT cells (P   Conclusions:  Genetic deletion of E2F1 in the BM progenitor cells enhances oxidative metabolism that may result in enhanced differentiation towards endothelial lineage and increased proliferation in the ischemic/hypoxic tissue environment. Therefore, inhibition of E2F1 in BM progenitor cells may improve the recovery from cardiac ischemic injury.
Cross sectional study of symptom attribution and recognition of depression and anxiety in primary care Commentary: There must be limits to the medicalisation of human distress
Authors: D. Kessler, K. Lloyd, G. Lewis, D. P. Gray, I. Heath
Journal: BMJ (1999)

# Cross sectional study of symptom attribution and recognition of depression and anxiety in primary care {#article-title-2} Objectives : To examine the effect of patients' causal attributions of common somatic symptoms on recognition by general practitioners of cases of depression and anxiety and to test the hypothesis that normalising attributions make recognition less likely. Design : Cross sectional survey. Setting : One general practice of eight doctors in Bristol. Subjects : 305 general practice attenders. Main outcome measure : The rate of detection by general practitioners of cases of depression and anxiety as defined by the general health questionnaire. Results : Consecutive attenders completed the general health questionnaire and the symptom interpretation questionnaire, which scores style of symptom attribution along the dimensions of psychologising, somatising, and normalising. General practitioners detected depression or anxiety in 56 (36%; 95% confidence interval 28% to 44%) of the 157 patients who scored highly on the general health questionnaire. Subjects with a normalising attributional style were less likely to be detected as cases; doctors did not make any psychological diagnosis in 46 (85%; 73% to 93%) of 54 patients who had high questionnaire and high normalising scores. Those with a psychologising style were more likely to be detected; doctors did not detect 21 (38%; 25% to 52%) of 55 patients who had high questionnaire and high psychologising scores. The somatisation scale was not associated with low detection rates. This pattern of results persisted after adjustment for age, sex, general health questionnaire score, and general practitioner. Conclusions : Normalising attributions minimise symptoms and are non-pathological in character. The normalising attributional style is predominant in general practice attenders and is an important cause of low rates of detection of depression and anxiety. # Commentary: There must be limits to the medicalisation of human distress {#article-title-17}
A new von Willebrand factor (vWF) defect in a patient with factor VIII (FVIII) deficiency but with normal levels and multimeric patterns of both plasma and platelet vWF. Characterization of abnormal vWF/FVIII interaction
Authors: C Mazurier, J Dieval, S Jorieux, J Delobel, M Goudemand
Journal: Blood (1990)