HYPERSENSITIVITY TO FOLIC ACID
Authors: D C MITCHELL, R W VILTER, C F VILTER
Journal: Annals of Internal Medicine (1949)

Case Reports1 December 1949HYPERSENSITIVITY TO FOLIC ACIDDANA C. MITCHELL, M.D., R. W. VILTER, M.D., F.A.C.P., C. F. VILTER, M.D.DANA C. MITCHELL, M.D.Search for more papers by this author, R. W. VILTER, M.D., F.A.C.P.Search for more papers by this author, C. F. VILTER, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-31-6-1102 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptSynthetic folic acid (pteroyl glutamic acid) has been used extensively in clinical investigation since November 1945 following reports of its effectiveness in the anemia of pernicious anemia, sprue and nutritional macrocytic anemia.1, 4It has been available for general use during the past years and although it has been helpful in controlling the anemia of persons with pernicious anemia who developed hypersensitivity reactions to liver extract, it has failed to prevent the neurologic complications of pernicious anemia.5Up to the time of writing hypersensitivity reactions to folic acid have not been noted though some persons who have received between 50...Bibliography1. DARBYJONES WJE: The treatment of sprue with synthetic Lactobacillus casei factor (folic acid, vitamin M), Proc. Soc. Exper. Biol. and Med., 1945, lx, 259. CrossrefGoogle Scholar2. DAVIDSONGIRDWOOD LSRH: Folic acid as a therapeutic agent, British Med. Jr., 1947, i, 587. CrossrefGoogle Scholar3. DOAN CA: Folic acid (synthetic L. casei factor), an essential panhematopoietic stimulus. Experimental and clinical studies, Am. Jr. Med. Sci., 1946, ccxii, 257. CrossrefGoogle Scholar4. SPIESVILTERKOCHCALDWELL TDCFMBMH: Observations in the antianemic properties of synthetic folic acid, South. Med. Jr., 1945, xxxviii, 707. CrossrefGoogle Scholar5. VILTERVILTERSPIES CFRWTD: The treatment of pernicious and related anemias with synthetic folic acid. I. Observations on the maintenance of a normal hematologic status and on the occurrence of combined system disease at the end of one year, Jr. Lab. and Clin. Med., 1947, xxxii, 262. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Cincinnati, Ohio*Received for publication August 18, 1947.From the Department of Internal Medicine, College of Medicine, University of Cincinnati, Cincinnati, Ohio. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byCHRONIC URTICARIA CAUSED BY FOLIC ACIDFolic acid-induced anaphylaxis showing cross-reactivity with methotrexate: a case report and review of the literatureDrug–Nutrient Interactions Involving FolateFolic acid in pregnancy and fetal outcomesAnaphylactic reaction to folic acid verified by provocational testingIn vitro demonstration of IgE antibody to folate-albumin in anaphylaxis from folic acidCorrespondenceSafety of Megavitamin TherapyVitaminsVitamin Excess and ToxicityALLERGY TO FOLIC ACIDHypersensitivity to Folic Acid in a Case of ErythroblastomatosisTHERAPY IN THE MEGALOBLASTIC ANAEMIAS OF PREGNANCYLARYNGEAL SPASMREACTIONS AFTER VITAMIN-B INJECTION 1 December 1949Volume 31, Issue 6Page: 1102-1105KeywordsFolic acidHypersensitivityLiverNutritionPernicious anemia ePublished: 1 December 2008 Issue Published: 1 December 1949 PDF downloadLoading ...