AN ARTICLE CONTRIBUTED TO AN ANNIVERSARY VOLUME IN HONOR OF DOCTOR JOSEPH HERSEY PRATT
Authors: RAPHAEL ISAACS
Journal: Annals of Internal Medicine (1937)

Article1 October 1937AN ARTICLE CONTRIBUTED TO AN ANNIVERSARY VOLUME IN HONOR OF DOCTOR JOSEPH HERSEY PRATTLYMPHOSARCOMA CELL LEUKEMIA*RAPHAEL ISAACSRAPHAEL ISAACSSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-11-4-657 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptIt has been observed frequently that the blood of patients with lymphosarcoma may become leukemic. This syndrome has been characterized as leukosarcoma by Sternberg1or as lymphosarcoma terminating in lymphatic leukemia.2, 3, 4Flashman and Leopold5noted 107 cases of this type in the literature and described an additional case. On the basis of a lymphosarcoma presumably terminating in lymphatic leukemia, numerous speculations have been published concerning the relationship of these two conditions. A careful cytological study of the cell types in this form of leukemia has shown, however, that the cells are not lymphocytes, but lymphosarcoma cells, so that...References1. STERNBERG C: Ueber Leukosarcomatose, Wien. klin. Wchnschr., 1908, xxi, 475. Google Scholar2. WEBSTER LT: Lymphosarcoma, lymphatic leukemia, leukosarcoma, Hodgkin's disease, Johns Hopkins Hosp. Bull., 1920, xxi, 458-461. Google Scholar3. EVANSLEUCUTIA WAT: The neoplastic nature of lymphatic leukemia and its relation to lymphosarcoma, Am. Jr. Roentgenol., 1926, xv, 497-513. Google Scholar4. DOUBHARTMAN HPFW: Lymphocytic, myelocytic and monocytic neoplasms; roentgen diagnosis and treatment, Jr. Am. Med. Assoc., 1935, cv, 942-948. CrossrefGoogle Scholar5. FLASHMANLEOPOLD DHSS: Leukosarcoma; with report of a case beginning with a primary retroperitoneal lymphosarcoma and terminating with leukemia, Am. Jr. Med. Sci., 1929, clxxvii, 651-663. CrossrefGoogle Scholar6. WARTHIN AS: The genetic neoplastic relationships of Hodgkin's disease, aleukaemic and leukaemic lymphoblastoma, and mycosis fungoides, Ann. Surg., 1931, xciii, 153-161. CrossrefGoogle Scholar7. WISEMAN BK: Lymphopoiesis, lymphatic hyperplasia, and lymphemia: Fundamental observations concerning the pathologic physiology and interrelationships of lymphatic leukemia, leukosarcoma and lymphosarcoma, ANN. INT. MED., 1936, ix, 1303-1329. Google Scholar8. KREBSRASK-NIELSENWAGNER CHCA: The origin of lymphosarcomatosis and its relation to other forms of leucosis in white mice. Lymphomatosis infiltrans leucemica et aleucemica, Acta Radiologica, 1930, supp. X, Stockholm. Google Scholar9. ISAACS R: The physiologic histology of bone marrow. The mechanism of the development of blood cells and their liberation into the peripheral circulation, Folia haemat., 1930, xl, 395-405. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Ann Arbor, Michigan*Presented to the Michigan Academy of Science, Arts and Letters, March 8, 1935, and, in abstract, to the American Society of Experimental Pathology, Washington, March 25, 1936. (Arch. Path., 1936, xxii, 287.)From the Thomas Henry Simpson Memorial Institute for Medical Research, University of Michigan, Ann Arbor, Michigan. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byCellular Morphologic Analysis of Peripheral BloodHistorical aspects of chronic lymphocytic leukaemiaInvestigation of cell size and nuclear clefts as prognostic parameters in chronic lymphocytic leukemiaProlymphocytic transformation of chronic lymphocytic leukemia. A report of three cases and review of the literatureChronic Lymphocytic Leukemia Recent Advances in Biology and TreatmentROBERT PETER GALE, M.D., Ph.D., KENNETH A. 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CONCEPTS, DEFINITIONS AND CLASSIFICATIONSPathologieHodgkin's disease terminating in acute lymphosarcoma cell leukemia.A metabolic studyAMYLOIDOSIS COMPLICATING STILL'S DISEASECHROMOSOMAL CHANGES IN BALKAN NEPHROPATHYQUANTITATIVE ELECTRON MICROSCOPY OF NORMAL AND LEUKÆMIC LYMPHOCYTESDiscussionLymphosarcoma cell leukemia.A clinicopathologic studyCentral nervous system complications of leukemic conversion of the lymphomasChronic lymphocytic leukemia versus chronic lymphosarcoma cell leukemiaLymphosarcoma cell leukemiaA study of malignant lymphomas and leukemias.VII. Lymphogenous leukemia and lymphosarcoma involvement of the lymphatic and hemic bed, with reference to differentiating criteriaUnusual Varieties of LeukemiaLYMPHOSARCOMA: THE EFFECTS OF THERAPY AND SURVIVAL IN 1,269 PATIENTS IN A REVIEW OF 30 YEARS' EXPERIENCE*†SAUL A. ROSENBERG, M.D., HENRY D. DIAMOND, M.D., F.A.C.P., LLOYD F. CRAVER, M.D., F.A.C.P.Newer Aspects in the Diagnosis and Treatment of Lymphomas and LeukemiasTHE DEVELOPMENT OF ACUTE MYELOGENOUS LEUKEMIA IN A PATIENT WITH RETICULUM CELL LYMPHOMA*ERNEST BEUTLER, M.D.Die Panmyelophthise und verwandte Zustände der KnochenmarksinsuffizienzVisceral involvement in primary neoplastic diseases of the reticulo-endothelial systemACUTE PLASMA CELL LEUKEMIA*LEO M. MEYER, M.D., JACOB HALPERN, M.D., FAITH N. OGDEN, M.D.Leucemia and PregnancyErgebnisse der Leukoseforschung der letzten Jahre 1 October 1937Volume 11, Issue 4Page: 657-662KeywordsBloodLymphocytesLymphocytic leukemia Issue Published: 1 October 1937 PDF downloadLoading ...