CHRONIC MENINGOCOCCEMIA COMPLICATED BY ACUTE ENDOCARDITIS
Authors: Robert B. Nye, Charles W. Semisch, Louis Merves
Journal: Annals of Internal Medicine (1942)

Case Reports1 June 1942CHRONIC MENINGOCOCCEMIA COMPLICATED BY ACUTE ENDOCARDITISROBERT B. NYE, M.D., F.A.C.P., CHARLES W. SEMISCH III, M.D., LOUIS MERVES, M.D.ROBERT B. NYE, M.D., F.A.C.P.Search for more papers by this author, CHARLES W. SEMISCH III, M.D.Search for more papers by this author, LOUIS MERVES, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-16-6-1245 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe etiological agent of epidemic cerebrospinal meningitis, the meningococcus, was first described in 1887 by Weichselbaum. Gwyn1demonstrated the meningococcus in the blood stream. W. W. Herrick, who has had a very extensive experience with meningococcic infections, divided the infection into three stages, viz: (1) local invasion of the upper respiratory tract, (2) invasion of the blood stream, (3) metastatic localization. It is the consensus of opinion at present2that in the pathogenesis of epidemic cerebrospinal meningitis, the pathway of infection is via blood stream rather than by direct extension from the nasopharynx, and that the process may terminate at...Bibliography1. GWYN NB: A case of general infection by the Diplococcus intracellularis of Weichselbaum, Bull. Johns Hopkins Hosp., 1899, x, 112-113. Google Scholar2. TOPLEYWILSON WWGS: Principles of bacteriology and immunity, 2nd Edition, 1936, William Wood and Co., Baltimore, page 1127. Google Scholar3. SOLOMON H: Über Meningokokkenseptikämie, Berl. klin. Wchnschr., 1902, xxxix, 1045. Google Scholar4. CARBONELLCAMPBELL AE: Prolonged meningococcemia, Arch. Int. Med., 1938, lxi, 646. CrossrefGoogle Scholar5. APPELBAUM E: Chronic meningococcus septicemia, Am. Jr. Med. Sci., 1937, cxciii, 96. CrossrefGoogle Scholar6. KRUSENELKINS FHEC: Fever therapy for gonococcemia and meningococcemia with associated endocarditis, Proc. Staff Meet. Mayo Clin., 1937, xii, 324. Google Scholar7. WILLIUSEATON FALM: Clinic on meningococcemia with vegetative mitral endocarditis (subacute bacterial endocarditis); with findings at postmortem examination, Proc. Staff Meet. Mayo Clin., 1937, xii, 762. Google Scholar8. HEINLE RW: Meningococcic septicemia, Arch. Int. Med., 1939, lxiii, 575. CrossrefGoogle Scholar9. BINNSCLANCY FJJ: Chronic meningococcemia promptly cured by sulfanilamide, Am. Jr. Dis. Child., 1939, lvii, 404. Google Scholar10. GOUNDRYPHALEN FWTH: Meningococcemia without meningitis, New York State Jr. Med., 1937, xxxvii, 491. Google Scholar11. ROSENBLUTHSTETTEN MBD: Meningococcus septicemia treated by fever therapy, New York State Jr. Med., 1938, xxxviii, 1078. Google Scholar12. ZENDELGREENBERG JFD: Meningococcemia, treatment with sulfanilamide and prontosil, New York State Jr. Med., 1937, xxxvii, 1744. Google Scholar13. TOPYOUNG FHDC: Continued fever, meningococcemia, Jr. Michigan State Med. Soc., 1938, xxxvii, 528. Google Scholar14. SCHWENTKERGELMANLONG FSPH: The treatment of meningococcic meningitis with sulfanilamide, Jr. Am. Med. Assoc., 1937, cviii, 1407. CrossrefGoogle Scholar15. HENNELLWEINER HHJ: Report of a case of chronic meningococcemia, Med. Jr. and Rec., 1930, cxxxi, 292. Google Scholar16. LONGBLISS PE: Clinical use of sulfanilamide and sulfapyridine and allied compounds, 1939, page 188, Macmillan Co., New York. Google Scholar17. HERRICK WW: Meningococcic sepsis, Cecil's Text Book of Medicine, Fourth Edition, 1937, W. B. Saunders Co., Philadelphia, page 199. Google Scholar18. DIMSON SB: Chronic meningococcal septicemia treated with 2-(p-Aminobenzene-sulphonamido) pyridine, Lancet, 1938, ii, 424. CrossrefGoogle Scholar19. HOBSONMCQUAIDE FGHG: Treatment of meningococcal meningitis with 2-Sulphanilyl-Amidopyridine (M & B 693), Lancet, 1938, ii, 1213. CrossrefGoogle Scholar20. BRANHAMROSENTHAL SESW: Sulfanilamide, serum, and combined drug and serum in the therapy of experimental meningococcic and pneumococcic infections in mice, Pub. Health Rep., 1937, lii, 685. CrossrefGoogle Scholar21. WAGHELSTEIN JM: Sulfanilamide in the treatment of 106 patients with meningococcic infections, Jr. Am. Med. Assoc., 1938, cxi, 2172. CrossrefGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Philadelphia, Pennsylvania*Received for publication August 2, 1940.From the Department of Therapeutics, Jefferson Medical College Hospital. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byChronic meningococcemiaSubacute bacterial endocarditis of nonstreptococcic etiology 1 June 1942Volume 16, Issue 6Page: 1245-1252KeywordsBacteremiaBloodMeningitisMeningococcal diseaseMeningococcemiaNeisseria meningitidisPathogenesisRespiratory systemRiversUpper respiratory tract infections ePublished: 1 December 2008 Issue Published: 1 June 1942 PDF downloadLoading ...