Variants of Glucose 6-Phosphate Dehydrogenase
Authors: IAN H. PORTER
Journal: Annals of Internal Medicine (1968)

Editorial Notes1 January 1968Variants of Glucose 6-Phosphate DehydrogenaseIAN H. PORTER, M.B., B.S.IAN H. PORTER, M.B., B.S.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-68-1-250 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptGlucose 6-phosphate dehydrogenase (G6PD) is the enzyme that catalyzes the first step in the pentose phosphate shunt. This enzyme attracted much medical interest when it was discovered that "primaquine sensitivity" was due to deficiency of this enzyme (1). Excitement was heightened when it was found that G6PD deficiency is an X-linked genetic condition (2, 3) and that it is common in Negroes and whites of Mediterranean origin which suggests, as in the case of the sickle cell gene, that its presence may be of some advantage.When a genetic condition is examined closely it usually turns out to be heterogeneous....References1. CARSONFLANAGANICKESALVING PECLCEAS: Enzymatic deficiency in primaquine sensitive erythrocytes. Science 124: 484, 1956. CrossrefMedlineGoogle Scholar2. CHILDSKINKHAMBROWNEKIMBOTORBERT BWHEAELJW: A genetic study of a defect in glutathione metabolism of the erythrocyte. Bull. Hopkins Hosp. 102: 21, 1958. MedlineGoogle Scholar3. PORTERSCHULZEMCKUSICK IHJVA: Genetical linkage between the loci for glucose-6-phosphate dehydrogenase deficiency and colour-blindness in American Negroes. Ann. Hum. Genet. 26: 107, 1962. CrossrefMedlineGoogle Scholar4. KIRKMANSCHETTINIPICKARD HNFBM: Mediterranean variant of glucose-6-phosphate dehydrogenase. J. Lab. Clin. Med. 63: 726, 1964. Google Scholar5. STAMATOYANNOPOULOSPANAYOTOPOULOSPAPAYANNOPOULOU GAT: Mild glucose-6-phosphate dehydrogenase deficiency in Greek males. Lancet 2: 932, 1964. CrossrefMedlineGoogle Scholar6. STAMATOYANNOPOULOSPAPAYANNOPOULOUBAKOPOULOSMOTULSKY GTCAG: Detection of glucose-6-phosphate dehydrogenase deficient heterozygotes. Blood 29: 87, 1967. CrossrefMedlineGoogle Scholar7. MARKSBANKSGROSS PAJRT: Genetic heterogeneity of glucose-6-phosphate dehydrogenase deficiency. Nature (London) 194: 454, 1962. CrossrefGoogle Scholar8. BOYERPORTERWEILBACHER SHIHRG: Electrophoretic heterogeneity of glucose-6-phosphate dehydrogenase and its relationship to enzyme deficiency in man. Proc. Nat. Acad. Sci. USA 48: 1868, 1962. CrossrefMedlineGoogle Scholar9. KIRKMANROSENTHALSIMONCARSONBRINSON HNIMERPEAG: "Chicago I" variant of glucose-6-phosphate dehydrogenase in congenital hemolytic disease. J. Lab. Clin. Med. 63: 715, 1964. MedlineGoogle Scholar10. KIRKMANRILEY HNHD: Congenital nonspherocytic hemolytic anemia. Amer. J. Dis. Child. 102: 313, 1961. CrossrefMedlineGoogle Scholar11. KIRKMANHENDRICKSON HNEM: Sex-linked electrophoretic difference in glucose-6-phosphate dehydrogenase in different populations. Amer. J. Hum. Genet. 15: 241, 1963. MedlineGoogle Scholar12. STAMATOYANNOPOULOSYOSHIDABACOPOULOSMOTULSKY GACAG: Another variant of glucose-6-phosphate dehydrogenase. Science 157: 831, 1967. CrossrefMedlineGoogle Scholar13. KAPLANROSASERINGEHOEFFEL JCRPJC: The genetic polymorphism of red cell glucose-6-phosphate dehydrogenase in man. 1st study of a slow variant with a normal activity. Enzym. Biol. Clin. (Basel) 8: 321, 1967. CrossrefMedlineGoogle Scholar14. KAPLANROSASERINGEHOEFFEL JCRPJC: The genetic polymorphism of red cell glucose-6-phosphate dehydrogenase in man. IInd study of a new variant with a diminished activity: the "Kabyle" type. Ibid., p. 332. Google Scholar15. PORTERBOYERWATSON-WILLIAMSADAMSZEINBERGSINISCOLO IHSHEJAAM: Variation of glucose-6-phosphate dehydrogenase in different populations. Lancet 1: 895, 1964. CrossrefMedlineGoogle Scholar16. Nomenclature of glucose-6-phosphate dehydrogenase in man. Bull. WHO 36: 319, 1967. MedlineGoogle Scholar17. Nomenclature of glucose-6-phosphate dehydrogenase in man. Acta Genet. (Basel) 17: 545, 1967. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: IAN H. PORTER, M.B., B.S.Affiliations: Department of Pediatrics Albany Medical College Albany, N. Y. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byTechniques for the Separation of IsoenzymesEnzyme Multiplicity in the Glycolytic Pathway and the Pentose—Phosphate CycleTechniques for the Separation of IsoenzymesEnzyme Multiplicity in the Glycolytic Pathway and the Pentose—Phosphate Cycle 1 January 1968Volume 68, Issue 1Page: 250-252KeywordsDehydrogenasesEnzymesGeneticsGlucosePhosphatesPrimaquine ePublished: 1 December 2008 Issue Published: 1 January 1968 PDF downloadLoading ...