tbuckley/cabot-search huggingface dataset:
The syringe skin hook: the history and evolution of the improvised skin hook
Authors: J.C.R. Bowling, J. Botting, E.V.J. Edmonds, N. Heaton, K.L. Agnew
Journal: British Journal of Dermatology (2004)

Journal Article The syringe skin hook: the history and evolution of the improvised skin hook Get access J.C.R. Bowling, J.C.R. Bowling Department of Dermatology, Chelsea & Westminster Hospital, 369 Fulham Road, London SW10 9NH, U.K. E‐mail: jonathan.bowling@chelwest.nhs.uk Search for other works by this author on: Oxford Academic Google Scholar J. Botting, J. Botting Department of Dermatology, Chelsea & Westminster Hospital, 369 Fulham Road, London SW10 9NH, U.K. E‐mail: jonathan.bowling@chelwest.nhs.uk Search for other works by this author on: Oxford Academic Google Scholar E.V.J. Edmonds, E.V.J. Edmonds Department of Dermatology, Chelsea & Westminster Hospital, 369 Fulham Road, London SW10 9NH, U.K. E‐mail: jonathan.bowling@chelwest.nhs.uk Search for other works by this author on: Oxford Academic Google Scholar N. Heaton, N. Heaton Department of Dermatology, Chelsea & Westminster Hospital, 369 Fulham Road, London SW10 9NH, U.K. E‐mail: jonathan.bowling@chelwest.nhs.uk Search for other works by this author on: Oxford Academic Google Scholar K.L. Agnew K.L. Agnew Department of Dermatology, Chelsea & Westminster Hospital, 369 Fulham Road, London SW10 9NH, U.K. E‐mail: jonathan.bowling@chelwest.nhs.uk Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 151, Issue 1, 1 July 2004, Page 244, https://doi.org/10.1111/j.1365-2133.2004.06052.x Published: 01 July 2004
Tumor Necrosis Factor and Interleuktn-1 in the Serum of Children with Severe Infectious Purpura
Authors: E Girardin, G E Grau, J M Dayer, P Roux-Lombard, P H Lambert
Journal: New England Journal of Medicine (1988)

Because of the possible involvement of cytokines in gram-negative septicemia, we investigated serum levels of tumor necrosis factor alpha, interleukin-1 beta, alpha interferon, and gamma interferon in children with gram-negative sepsis and purpura fulminans. We studied 55 patients (ages, 1 month to 19 years) with a clinical diagnosis of sepsis and purpuric lesions who were in shock or had three or more other biologic risk factors. The mortality rate was correlated with the number of risk factors present on admission to the hospital (P = 0.03). Tumor necrosis factor alpha was elevated in 91 percent of the 35 patients tested, interleukin-1 in 21 percent of the 33 patients tested, and gamma interferon in 19 percent of the 32 tested. Alpha interferon levels were within normal limits in the 32 patients tested. Serum levels of tumor necrosis factor alpha were positively correlated with the number of risk factors (P<0.05) and negatively correlated with blood fibrinogen levels (P = 0.01). Tumor necrosis factor alpha, interleukin-1, and gamma interferon were significantly higher in patients who died than in the survivors. Alpha interferon levels were similar in the two groups. Serum concentrations of both interleukin-1 and gamma interferon were correlated with concentrations of tumor necrosis factor alpha. These data provide evidence that serum levels of tumor necrosis factor alpha, interleukin-1, and gamma interferon correlate with the severity of meningococcemia in children. The findings may have implications for new therapeutic approaches. (N Engl J Med 1988; 319: 397–400.)
Biochemical and Immunologic Analysis of Hereditary Myeloperoxidase Deficiency
Authors: William M. Nauseef, Richard K. Root, Harry L. Malech
Journal: Journal of Clinical Investigation (1983)

Myeloperoxidase (MPO), a heme enzyme present in the azurophilic granules of human polymorphonuclear neutrophils (PMN), is important in the oxygen-dependent microbicidal activity of PMN. MPO deficiency, defined as the lack of PMN peroxidative activity, is a common genetic defect of human PMN. The purpose of our study was to characterize the structural basis for this loss of enzymatic activity, using protein biochemical and immunochemical techniques to examine PMN from three subjects with partial MPO deficiency and from five subjects with complete MPO deficiency.
Reproductive health of Arab young people
Authors: Jocelyn DeJong, Golda El-Khoury
Journal: BMJ (2006)

international non-governmental organisations providing emergency relief in Lebanon should work closely with local health providers to rebuild services and plan for longer term care.Working in partnership with local communities will help expand affordable health care coverage, encourage retention of the workforce, promote resiliency, and begin a healing process to a hugely traumatised and dispossessed population.
BRCA mutation in Chinese population: results from the Hong Kong hereditary and high risk breast cancer programme (HRBCP) and the Hong Kong hereditary and high risk breast cancer family registry.
Authors: A Kwong, CL Wong, ES Ma, DW West, JM Ford
Journal: Cancer Research (2009)

Abstract Abstract #3097 Background: Little is known about the frequency and spectrum of BRCA 1/2 mutations among Chinese population. Previous research suggests possible differences in the prevalence and penetrance of inherited mutations in these genes among Asians and the earlier presentation of breast cancer in Asian population may have more relevance to genetic causes. The access to genetic counseling and testing in Asia have been limited. The HRBCP (www.HRBCP.org) was established in 2007. This is first in Hong Kong and provides genetic testing, counseling and research on the spectrum of the disease in Asia and in particular Chinese population. The data from this programme will be entered in the newly established The Hong Kong Hereditary Breast Cancer Family Registry.&amp;#x2028; Methods: Probands who were diagnosed to have breast cancer age 50 or below, have a family history or personal history of breast and/or ovarian cancer, bilateral breast cancer, male breast cancer, triple negative breast carcinoma were recruited. Genetic counseling were given and consent for testing were obtained. Blood and tumor samples were collected. The entire coding regions of the extracted DNA/RNA and flanking introns of BRCA1 and 2 were screened for germline mutations using full gene sequencing and MLPA.&amp;#x2028; Results: A total of 119 Chinese have been sequenced and analysed. 21 (18%) deleterious mutations were identified of which 4 were novel mutations. 8 (38%) were BRCA 1 mutations and 13 (62%) were BRCA 2 mutations. 66.6% had first degree relatives with breast cancer. 49 (41.2%) were under the age of 40 years old of which 11 (22%) were found to carry a BRCA mutation. 7 (64%) of this younger age group with mutation have family history of breast cancer. For the other 4, 1 had triple negative cancer, 1 had a family history of ovarian cancer, 1 unknown and 1 with no risk except for young age. Of the 37 family members tested, 21 (57%) have BRCA mutations and only 9 of them have breast or ovarian cancers. 1 only had stomach cancer. 6 male family members were found to carry the BRCA mutation with no history of cancer.&amp;#x2028; Conclusions: Approximately 18% of the tested blood samples from clinically high risk Chinese women carry a deleterious mutation in BRCA1 or 2. In contrast to Caucasian data, there was a comparative higher rate of BRCA2 mutations. Further research on the spectrum of the mutations in Chinese and other Asian population will allow the tailor-making of an ethnic-based risk assessment model and also screening, prophylactic and preventative measures to be taken. Citation Information: Cancer Res 2009;69(2 Suppl):Abstract nr 3097.
Prediction of Biologic Aggressiveness in Human Meningiomas: A Cell Kinetic Study Using Bromodeoxy-uridine in Cells of Primary Explant Culture
Authors: K. Kharbanda, A. K. Karak, C. Sarkar, A. K. Dinda, M. Mathur, S. Roy
Journal: JNCI Journal of the National Cancer Institute (1992)

Journal Article Prediction of Biologic Aggressiveness in Human Meningiomas: A Cell Kinetic Study Using Bromodeoxy-uridine in Cells of Primary Explant Culture Get access Kusum Kharbanda, Kusum Kharbanda Department of Pathology, All India Institute of Medical SciencesAnsari Nagar, New Delhi, India Search for other works by this author on: Oxford Academic PubMed Google Scholar Asis K. Karak, Asis K. Karak Department of Pathology, All India Institute of Medical SciencesAnsari Nagar, New Delhi, India Search for other works by this author on: Oxford Academic PubMed Google Scholar Chitra Sarkar, Chitra Sarkar * Department of Pathology, All India Institute of Medical SciencesAnsari Nagar, New Delhi, India * Correspondence to: Chitra Sarkar, M.D., Department of Pathology, All India Institute of Medical Sciences, Ansari Nagar, New Delhi 110029, India. Search for other works by this author on: Oxford Academic PubMed Google Scholar Amit K. Dinda, Amit K. Dinda Department of Pathology, All India Institute of Medical SciencesAnsari Nagar, New Delhi, India Search for other works by this author on: Oxford Academic PubMed Google Scholar Meera Mathur, Meera Mathur Department of Pathology, All India Institute of Medical SciencesAnsari Nagar, New Delhi, India Search for other works by this author on: Oxford Academic PubMed Google Scholar S. Roy S. Roy Department of Pathology, All India Institute of Medical SciencesAnsari Nagar, New Delhi, India Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 84, Issue 3, 5 February 1992, Pages 194–196, https://doi.org/10.1093/jnci/84.3.194 Published: 05 February 1992 Article history Received: 30 May 1991 Revision received: 01 November 1991 Accepted: 13 November 1991 Published: 05 February 1992
Diabetogenic effect of oral diuretics.
Authors: J. G. Domenet
Journal: BMJ (1968)

Diabetogenic Effect of Oral Diuretics SIR,-The study by Drs.O. O. Andesen and I. Persson (29 June, p. 798) does not claim to help resolve the problem of the mechanism of the diabetogenic effect of cer- tain oral diuretics.It does present, however, a comparative study of two drugs, ethacrynic acid and chlorthalidone.The conclusion reached is that " Increased values in this test
Better training is needed to deal with increasing multimorbidity
Authors: N. Hawkes
Journal: BMJ (2012)

Patients with multiple health problems are the norm not the exception, and the NHS is not set up to treat them properly, concludes a study carried out in Scotland. Most healthcare, research and education focuses on single diseases while many patients have several, and a new strategy is needed. Financed by the Scottish government’s Chief Scientist Office and published in the Lancet , the study was led by Bruce Guthrie of Dundee University and Stewart Mercer and Graham Watt of Glasgow University. They used a dataset covering 314 medical practices in Scotland, representing 1.75 million patients, and extracted data on 40 morbidities, working out how many patients were diagnosed as having one, two, or more.

Although multiple morbidities are recognised as being more common among older people, the team found that there were more in absolute terms in those under …
P735Regulation of macrophage polarization by extracellular RNA: The role of sialoadhesin-1
Authors: H A Cabrera-Fuentes, S Galuska, S Meiler, Y Baumer, S Mccurdy, S Fischer, KT Preissner, W Boisvert
Journal: Cardiovascular Research (2014)

Macrophages respond to external stimuli with rapid changes in their expression of many inflammation-related genes to undergo polarization towards the M1 (pro-inflammatory) or M2 (anti-inflammatory) phenotype. This unique property of macrophages allows these cells to modulate chronic inflammatory processes such as atherogenesis. We have previously shown that extracellular RNA (eRNA) can exert prothrombotic and inflammatory properties in the vasculature as a cofactor in protease auto-activation and cytokine mobilization. Given the association of eRNA with macrophages within atherosclerotic lesions, we assessed whether eRNA generated by the macrophages themselves may induce inflammatory responses within macrophages, independent of Toll-like receptor signaling. Recombinant mouse macrophage CSF-driven bone marrow-derived macrophage (BMDM) differentiation was skewed towards the M1 phenotype by exposure of cells to eRNA. This resulted in the overexpression of inflammatory markers such as Tnf-α, Arg2, Il-1β, Il-6, or Ifn-Γ together with Il-12 and iNOS, whereas anti-inflammatory genes such as Il-10 and Il-4 together with Arg1 and macrophage mannose receptor-2 (Cd206) were significantly down-regulated by eRNA. Accordingly, the release of TNF-α and IL-6 proteins into the cell supernatant was significantly elevated by eRNA stimulation. Moreover, the capacity of granulocyte macrophage CSF-driven BMDM differentiation (already representing M1 phenotype) towards further M1 polarization in response to eRNA was moderate. Nevertheless, a significant down-regulation of M2 markers was found. Sialoadhesin-1 (SN-1) is a membrane-anchored basic protein, predominantly expressed on macrophages and involved in cellular interactions via recognition of sialylated glycoconjugates. Interestingly, exposure of SN-1-/- BMDM towards eRNA resulted in prominent down-regulation of pro-inflammatory cytokines together with M1 phenotype markers, while anti-inflammatory cytokines together with M2 phenotype mediators were significantly raised. In accordance with our proposal that eRNA serves as pro-inflammatory "alarm signal" during physiologically distressed conditions, these data may shed light on the role of eRNA and macrophages in chronic inflammatory environment such as atherosclerosis. The self-perpetuating process of atherosclerosis as a largely inflammation-driven pathology may be controlled by SN-1 expression on lesional macrophages as well as the injury-mediated release of eRNA as a master trigger in inflammation.
Series Elasticity in Heart Muscle
Authors: WILLIAM W. PARMLEY, EDMUND H. SONNENBLICK
Journal: Circulation Research (1967)

The series elasticity (SE) of cat papillary muscle was measured in 6 muscles by the isotonic quick-release method, with careful correction for the compliance of the equipment. The resultant SE curve was exponential in form with an extension of 4% to 5% of initial muscle length for a preload of 0.5 g and a developed tension of 10 g; this demonstrates a stiffer SE for cardiac muscle than has previously been reported. The quick-release SE extension curve was unaffected by inotropic interventions or changing the time of quick release, and was less compliant than the SE curves calculated by two different isotonic methods. These differences arise from the fact that contractile element velocity has a secondary rise during the transition from the isometric to isotonic phase of any afterloaded contraction. With increasing preload (and initial muscle length) the SE became stiffer, suggesting that a substantial part of it is in series with both the contractile and parallel elastic elements.
Physiological or pathological?
Authors: F. Marchetti, G. Tornese, A. Ventura
Journal: BMJ (2010)

The evidence for using off label drugs in children with gastro-oesophageal reflux is poor.1 However, the first step is to differentiate physiological gastro-oesophageal reflux from pathological gastro-oesophageal reflux disease. Many symptoms commonly attributed to the pathological disease (crying, regurgitation, feeding refusal, wheezing) may more appropriately be …
Tetramer-assisted identification and characterization of epitopes recognized by HLA A*2402–restricted Epstein-Barr virus–specific CD8+ T cells
Authors: Kiyotaka Kuzushima, Naomi Hayashi, Ayumi Kudoh, Yoshiki Akatsuka, Kunio Tsujimura, Yasuo Morishima, Tatsuya Tsurumi
Journal: Blood (2003)
BRCA Mutations and Ductal Carcinoma In SituBRCA
Authors: William D Foulkes, Nancy Hamel, Kathleen Klein Oros, Patricia N Tonin
Journal: JAMA (2005)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Deficient Nucleotide Excision Repair Capacity Enhances Human Prostate Cancer Risk
Authors: Jennifer J. Hu, M. Craig Hall, Lawrence Grossman, Mohammad Hedayati, David L. McCullough, Kurt Lohman, L. Douglas Case
Journal: Cancer Research (2004)

Abstract Prostate cancer (CaP) is the most commonly diagnosed non-skin cancer and the second leading cause of cancer death in American men. The etiology of CaP is not fully understood. Because most of the DNA adducts generated by some CaP-related carcinogens, including polycyclic aromatic hydrocarbons, heterocyclic amines, and pesticides, are removed by the nucleotide excision repair (NER) pathway, we pilot tested the hypothesis that CaP is associated with deficient NER capacity (NERC), measured by a plasmid-based host reactivation assay. Using cryopreserved lymphocytes collected in an ongoing, clinic-based case-control study, our results showed that the mean NERC was significantly lower (P = 0.03) in 140 cases (mean ± SD, 8.06 ± 5.17) than in 96 controls (9.64 ± 5.49). There was a significant association between below-median NERC and CaP risk: odds ratio (OR), 2.14; 95% confidence interval (CI), 1.19–3.86, after adjustment for age, race/ethnicity, smoking history, benign prostatic hyperplasia, and family history. This association was stronger in younger (&amp;lt;60 years of age) subjects (OR, 3.98; 95% CI, 1.13–14.02) compared with older (≥60) subjects (OR, 1.74; 95% CI, 0.90–3.37). When we stratified NERC values by quartiles of controls, there was a significant dose-dependent association between lower NERC and elevated CaP risk (p test for linear trend, 0.01). Compared with the highest quartile of NERC as the referent group, the adjusted ORs for the 75th, 50th, and 25th quartiles were: 1.09 (95% CI, 0.46–2.59); 1.81 (95% CI, 0.77–4.27); and 2.63 (95% CI, 1.17–5.95), respectively. This pilot study is the first direct evidence associating deficient NERC with human CaP risk.
A conversation with Paul Marks
Authors: Ushma S. Neill
Journal: Journal of Clinical Investigation (2012)

Paul Marks is recognized as a leader in the cancer field and as a world-class scientist, clinician, and administrator. He served as president and CEO of Memorial Sloan-Kettering Cancer Center (MSKCC) between 1980 and 1999 after serving as the dean (1970–1973) and vice president for Medical Sciences (1973–1980) of the Columbia University College of Physicians and Surgeons (P&S). Marks (Figure ​(Figure1)1) led the discovery, testing, and recent approval of SAHA (suberoylanilide hydroxamic acid), the treatment for cutaneous T-cell lymphoma. SAHA and other histone deacetylase (HDAC) inhibitors are now undergoing trials for a broad array of cancers. The full interview can be seen on the JCI website, http://www.jci.org/kiosk/cgm.
A PLEA FOR A CLINICAL PHYSIOLOGY
Authors: J. Mackenzie
Journal: BMJ (1924)

TuA B to check the production of this poisonous eniolic group, which ultimately oveirwllelms the body.IJnsulin, oni the other lhanid, stirikes at the Iroot of the nlisehief.But it remains true that any increase in the lhydrogen-iGn conieentration of the blood produces dyspnoea.It is
Antibody Depletion by Bortezomib through Blocking of Antigen Presentation
Authors: Se Jin Park, Hae Il Cheong, Jae Il Shin
Journal: New England Journal of Medicine (2013)

any disease-control effort.Global health governance must encourage multisectoral collaboration, including collaboration with the militaries of the world and especially in conflict zones.In fact, where this has occurred, there have been notable successes, including disaster relief, vaccine development, and influenza surveillance. 2
Assessing human exposure to phthalates using monoesters and their oxidized metabolites as biomarkers.
Authors: Dana B Barr, Manori J Silva, Kayoko Kato, John A Reidy, Nicole A Malek, Donald Hurtz, Melissa Sadowski, Larry L Needham, Antonia M Calafat
Journal: Environmental Health Perspectives (2003)

Phthalates are a group of industrial chemicals with many commercial uses, such as solvents, additives, and plasticizers. For example, di-(2-ethylhexyl) phthalate (DEHP) is added in varying amounts to certain plastics, such as polyvinyl chloride, to increase their flexibility. In humans, phthalates are metabolized to their respective monoesters, conjugated, and eliminated. However, despite the high production and use of DEHP, we have recently found that the urinary levels of the DEHP metabolite mono-(2-ethylhexyl) phthalate (MEHP) in 2,541 persons in the United States were lower than we anticipated, especially when compared with urinary metabolite levels of other commonly used phthalates. This finding raised questions about the sensitivity of this biomarker for assessing DEHP exposure. We explored the utility of two other DEHP metabolites, mono-(2-ethyl-5-oxohexyl) phthalate (MEOHP) and mono-(2-ethyl-5-hydroxyhexyl) phthalate (MEHHP), as additional DEHP biomarkers. These metabolites are formed by oxidative metabolism of MEHP. In urine from 62 people, both the range and the mean urinary levels of MEOHP and MEHHP were on average 4-fold higher than those of MEHP; the mean of the individual ratios of MEHHP/MEOHP, MEHHP/MEHP, and MEOHP/MEHP were 1.4, 8.2, and 5.9, respectively. These data suggest that MEOHP and MEHHP are more sensitive biomarkers of exposure to DEHP than is MEHP. These findings also suggest a predominant human metabolic route for DEHP hydrolysis to MEHP followed by oxidation of MEHP; they also imply that a similar mechanism may be relevant for other high-molecular-weight phthalates, such as di-n-octyl, di-isononyl, and di-isodecyl phthalates.
Localization of hepatitis B antigen in liver organ cultures.
Authors: A J Zuckerman, R G Bird
Journal: BMJ (1973)

miRnsH MEDICAL JouRNAL 26 MAY 1973 to intervene inmiediately in crisis situations, and worked out a shorter and more practical technique of interviewing than social workers are traditionally taught.I suspect that many more social workers would do the same if given the chance.At present most of them can only be contacted during office hours and then only if the clerk in the social services department office chooses to tell them that you phoned.The ideal would be local-authority attachment to particular prac- tices, but the next best thing would be re- imbursement of the social workeres salary.