PROTEIN BALANCE STUDIES IN PATIENTS WITH LIVER DAMAGE. II. THE RÔLE OF LIPOTROPIC AGENTS
Authors: L W KINSELL, G D MICHAELS
Journal: Annals of Internal Medicine (1948)

Article1 November 1948PROTEIN BALANCE STUDIES IN PATIENTS WITH LIVER DAMAGE. II. THE RÔLE OF LIPOTROPIC AGENTSLAURANCE W. KINSELL, M.D., F.A.C.P., GEORGE D. MICHAELS, Ph.D., HARRY C. BARTON, M.D., HARRY A. WEISS, M.D.LAURANCE W. KINSELL, M.D., F.A.C.P.Search for more papers by this author, GEORGE D. MICHAELS, Ph.D.Search for more papers by this author, HARRY C. BARTON, M.D.Search for more papers by this author, HARRY A. WEISS, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-29-5-881 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptDuring the decade 1932-1942 a considerable body of data accumulated, which completely revamped prior concepts of liver damage, in that nutritional factors assumed a rôle of increasing importance in pathogenesis; prophylaxis, and treatment. The experimental work which produced this revolution emanated from several groups of investigators.Best, Hershey and Huntsman1in 1932 showed that choline would prevent fatty liver, and in 1935 Best and Huntsman2noted that casein acted in a similar fashion when administered to rats on a high fat diet. In 1937 Tucker and Eckstein3demonstrated that methionine was largely, if not entirely, responsible for the "lipotropic" (i.e.,...Bibliography1. BESTHERSHEYHUNTSMAN CHJMME: The effect of lecithine on fat deposition in the liver of the normal rat, Jr. Physiol., 1932, lxxv, 56-66. CrossrefGoogle Scholar2. BESTHUNTSMAN CHME: The effect of choline on the liver fat of rats in various states of nutrition, Jr. Physiol., 1935, lxxxiii, 255-274. CrossrefGoogle Scholar3. TUCKERECKSTEIN HFHC: Effect of supplementary methionine and cystine on production of fatty livers by diet, Jr. Biol. Chem., 1937, cxxi, 479. CrossrefGoogle Scholar4. 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Author, Article, and Disclosure InformationAffiliations: Oakland, California*This paper was presented in part at the annual meeting of the Western Society for Clinical Research, which met in San Francisco on November 8, 1947. Received for publication March 18, 1948.This work has been performed under a grant from the Office of Naval Research.Acknowledgments are made to Dr. Cox, of the Mead-Johnson Company, for supplies of Amigen; to the Wyeth Company, for supplies of methionine, "Meonine"; to Anheuser-Busch, Inc., for supplies of yeast of high vitamin content; to the Eli Lilly Company, for supplies of alpha tocopherol.Division of Medicine, University of California School of Medicine; Department of Medicine, United States Naval Hospital: San Francisco and Oakland, California. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byOCCURRENCE OF ACCUMULATION OF FAT IN THE LIVER AND ITS RELATION TO EXCESS WEIGHT GAIN IN PATIENTS CONVALESCING FROM VIRAL HEPATITIS*ARTHUR R. COLWELL JR., M.D.ErnährungstherapieErnährungstherapieThe Treatment of Liver DiseaseThe Medical Management of Severe Liver DiseaseNutrition and Disease of the LiverTotal Solids, Fat and Nitrogen in the Feces: V. A Study of Patients With Primary Parenchymatous Hepatic DiseaseThe Nutritional Aspects of Liver Injury 1 November 1948Volume 29, Issue 5Page: 881-902KeywordsDietFatsFatty liverHospital medicineLiverMethionineNutritionPathogenesisProphylaxisProteins Issue Published: 1 November 1948 PDF downloadLoading ...