tbuckley/cabot-search huggingface dataset:
Abstract 1882: The expression phenotype of SNPs linked to the risk for prostate cancer
Authors: Xin Chen, Zhenyu Jia, Michael McClelland, Farah Rahmatpanah, Dan Mercola
Journal: Cancer Research (2014)

Abstract Numerous Genome Wide Association (GWA) studies of large populations have provided limited biomarkers for cancer and few linkages to phenotype. We investigated whether SNPs that are known to be associated with prostate cancer (PCa) affect expression in prostate stroma. The stroma of prostate tumors provides genetically homogenous tissue type with hundreds of tumor-dependent expression changes [1] which favors linkage identification. We surveyed published GWA studies covering a total of ∼90,000 patients and selected the most significant 35 susceptibility loci for further linkage analysis. We also selected 4030 transcripts previously associated with PCa diagnosis and prognosis. We then investigated 47 PCa cases using genetic variations in nontumor DNA (Illumina Human1M-Duov3_B snp arrays) and correlating the genotypes with RNA gene expression data from the same patients (U133 plus 2.0 arrays). A novel eQTL (Expression Quantitative Trait Loci) analysis was carried out by a modified BAYES method to analyze the associations between the risk variants and expressed transcripts jointly in a single model. The model assumed that a risk variant can be associated with multiple RNA expression changes and vice versa. We observed 47 significant linkages between 8 risk variants and 46 significant expression changes. The false discovery rates of two resampling studies are 0.03 and 0.05, respectively, which indicated the 47 linkages are significant. All linkages are “trans' linkages indicating remote effects of key SNPs on expressing genes. This is the first study to identify trans-linkages between multiple SNPs and multiple significant expression changes identified in cancer stroma. The linkages also associated with trends in clinical phenotypes. The strongest trend is between linkage rs9623117(C)-FOXD1 and biochemical relapse (p=0.01). The study reveals links between SNPs associated with PCa risk and transcription, which may identify the subset of patients where these genotypes may affect relevant phenotypes. [1] Jia et al., Cancer Research 2011; 71:2476-2487. Citation Format: Xin Chen, Zhenyu Jia, Michael McClelland, Farah Rahmatpanah, Dan Mercola. The expression phenotype of SNPs linked to the risk for prostate cancer. [abstract]. In: Proceedings of the 105th Annual Meeting of the American Association for Cancer Research; 2014 Apr 5-9; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2014;74(19 Suppl):Abstract nr 1882. doi:10.1158/1538-7445.AM2014-1882
Abstract 3292: Cardiac Dysfunction Induced By Chronic Restrain Stress Is Mediated By Opioid Receptors
Authors: Jinping Gao, Chu C Chua, Deling Yin, Hong Wang, Ronald C Hamdy, Balvin Chua
Journal: Circulation (2007)

Psychological and physical stressors are a major health problem in our society. The effect of chronic stress on myocardial function has not been assessed. Our hypothesis is that chronic stress induces cardiac dysfunction and that its effect is mediated by activation of opioid receptors (OPR). Six week-old male ICR mice were restrained for 12 h with no food and water. This was followed by 12 h of rest with food and water provided ad labium. Unstressed (control) mice were kept in the original cage and were not given food and water during the stress period of the experimental group. Left ventricular performance was analyzed in mice anesthetized with 2% isoflurane using an ARIA pressure-volume conductance system (Millar Instruments). Our studies demonstrated for the first time that cardiac function was significantly depressed in restrained mice, as evidenced by a significant decrease in body weight (9%), heart rate (21%), stroke volume (38%), cardiac output (52%), ejection fraction (27%) and preload recruitable stroke work (43%). Systolic function (control vs. stressed group) (P&lt;0.05), was 88 ± 2.2 vs. 68 ± 2.8 mmHg for end-systolic pressure, 6.1 ± 0.15 vs. 7.6 ± 0.15 μl for end-systolic volume, and 11,471 ± 913 vs. 5,860 ± 761 mmHg/s for +dP/dt. Diastolic function (control vs. stressed group) (P&lt;0.05), was 2.9 ± 0.3 vs. 5.0 ± 0.5 mmHg for end-diastolic pressure, 17.1 ± 0.4 vs. 14.4 ± 0.5 μl for end-diastolic volume, 7,678 ± 419 vs. 4,195 ± 358 mmHg/s for -dP/dt, and 7.1 ± 0.5 vs. 10.8 ± 1.1 ms for tau (time constant of isovolumic relaxation). Peripheral vascular resistance (Ea) increased from 7.7 ± 0.2 in the control group to 9.8 ± 0.7 mmHg/μ l in the stressed group (P&lt;0.05). Administration of an opioid antagonist naltrexone (8 mg/kg, i.p.) during each cycle of stress completely restored the cardiac function of stressed mice. Naltrexone alone had no effect on cardiac function in unstressed mice. These intriguing data suggest that opioid receptors are involved in the chronic stress-induced cardiac dysfunction and that treatment with an opioid antagonist can prevent this cardiac dysfunction.
GATA factor transgenes under GATA-1 locus control rescue germline GATA-1 mutant deficiencies
Authors: Satoru Takahashi, Ritsuko Shimizu, Naruyoshi Suwabe, Takashi Kuroha, Keigyou Yoh, Jun Ohta, Shigeko Nishimura, Kim-Chew Lim, James Douglas Engel, Masayuki Yamamoto
Journal: Blood (2000)
Glucocerebrosidase Gene Mutation and Preclinical Markers of Parkinson Disease
Authors: Antonella Macerollo
Journal: JAMA Neurology (2015)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Neurology HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Neurology journal
Ultrasound Assessment of Synovial Pathologic Features in Rheumatoid Arthritis Using Comprehensive Multiplane Images of the Second Metacarpophalangeal Joint: Identification of the Components That Are Reliable and Influential on the Global Assessment of the
Authors: Kei Ikeda, Yohei Seto, Akihiro Narita, Atsushi Kawakami, Yutaka Kawahito, Hiromu Ito, Isao Matsushita, Shigeru Ohno, Keiichiro Nishida, Takeshi Suzuki, Atsushi Kaneko, Michihiro Ogasawara, Jun Fukae, Mihoko Henmi, Takayuki Sumida, Tamotsu Kamishima, Takao Koike
Journal: Arthritis & Rheumatology (2013)

The aim of this pilot study was to provide groundwork that could be utilized to optimize the global ultrasound (US) assessment of the whole joint for synovial pathologic features in patients with rheumatoid arthritis (RA).US images of the second metacarpophalangeal joint in 8 predefined imaging planes, comprising regions that comprehensively capture the synovial pathologic features of the whole joint, were obtained from 30 patients with RA. Twelve experienced sonographers evaluated these images at the level of both the individual image and the whole joint, using a visual analog scale (VAS) to assess pathologic severity. Interrater reproducibility of the VAS scores was evaluated with intraclass correlation coefficients (ICCs), and factors that independently influenced the global assessment of the whole joint were identified using multiple linear regression analysis.A total of 14,276 VAS scores were analyzed. Interrater reproducibility of any eligible VAS assessment of synovial pathologic features was good (ICC 0.65). US assessment of synovial pathologic features in joints with mild inflammation was less reproducible than that in joints with severe inflammation. Although the most severely affected region in a joint did not always represent the average pathologic severity among the 8 regions, global assessment of the whole joint strongly correlated with assessment of the most severely affected region (P < 0.001). Importantly, the standard, midline imaging plane was not the most influential plane on the global assessment of the whole joint. Assessment of synovial fluid accumulation was not reproducible (ICCs 0.20-0.42) and did not substantially influence the global assessment of synovial inflammation (β = 0.06).The results of this study provide a unique data set that could be utilized to optimize the global US assessment of synovial pathologic features of the whole joint in patients with RA.
Grundriss und Atlas der speziellen Chirurgie.
Authors: Georg Sultan
Journal: JAMA (1910)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Regeneration of elastic fibers by three-dimensional culture on a collagen scaffold and the addition of latent TGF-β binding protein 4 to improve elastic matrix deposition
Authors: Rino Aya, Toshihiro Ishiko, Kazuo Noda, Satoko Yamawaki, Yuki Sakamoto, Kenji Tomihata, Yasuhiro Katayama, Katsuhiro Yoshikawa, Hiroshi Kubota, Tomoyuki Nakamura, Motoko Naitoh, Shigehiko Suzuki
Journal: Biomaterials (2015)

The objective of this study was to investigate the effects of latent TGF-β binding protein 4 (LTBP-4) on elastic fiber regeneration in three-dimensional cultures of human dermal fibroblasts (HDFs). Appropriate collagen scaffold for elastic fiber regeneration was also examined. Collagen sponges cross-linked at 120 °C and composed of small pores (25 μm on average) was favorable for elastic fiber regeneration by HDFs. Addition of LTBP-4, followed by culture for 21 days, accelerated elastic fiber accumulation within the scaffolds. Conditioned scaffolds containing either HDFs or LTBP-4-built mature elastic fibers were implanted between the dermis and the cutaneous muscle of mice. The combined use of HDFs and LTBP-4 resulted in thicker tissues containing elastic fibers. These results indicate that weakly cross-linked collagen sponges can be used as scaffolds for regenerating elastic fibers both in vitro and in vivo, and that the addition of LTBP-4 accelerates the deposition of both elastin and fibrillin-1, and increases cell proliferation. These techniques may be useful for generating cutaneous or cardiovascular tissue equivalents; furthermore, they may serve as a useful method for the three-dimensional analyses of drugs used to treat skin diseases or to examine the microstructure of elastin networks.
In brief
Authors: A Ferriman
Journal: BMJ (2001)

Sub-Saharan Africa is bound to become the biggest user of antiretroviral drugs in the world, so it has to start preparing to use them now, a conference of AIDS experts was told last week.

More than 25 million people in the region are HIV positive, out of a total of 36 million worldwide, yet only a few thousand are being treated with antiretroviral drugs. These drugs could turn AIDS in Africa into a treatable, though chronic, disease, as they have done in the United States, Europe, and Australia, the conference heard.

Dr Peter Mugyenyi, director of the Joint Clinical Research Centre in Kampala, Uganda, told the conference, hosted by the centre and convened by the Rockefeller Foundation, that there was “moral outrage” over the continued loss of prime life in Africa when effective drugs existed and were cheap to manufacture.

“Be conscious of the deadly high cost of delay, and act now,” Dr Mugyenyi said. “Three million people died last year alone, of which an estimated 2.4 million were Africans. That is the equivalent of the populations of Botswana and Swaziland put together,” he told the 200 participants, who were drawn from academia, technical agencies such as the World Health Organization (WHO) and the National Institutes of Health, donor foundations, and non-governmental organisations.

Dr Mugyenyi said that …
Abstract 18801: Intracardiac Mesenchymal Stem Cells Restore Endothelial Function in Heart Failure by Stimulating the Release of Endothelial Progenitor Cells
Authors: Courtney Premer, Arnon Blum, Michael Bellio, Ivonne H Schulman, Julio Sierra, Cindy Delgado, Barry Hurwitz, Darcy Difede, Meela Parker, Phillip Gonzalez, Joshua M Hare
Journal: Circulation (2014)

Background: While mesenchymal stem cells (MSCs) exert immunomodulatory and antifibrotic effects in humans, preclinical studies also indicate that these cells can interact with host precursor cells, so as to promote tissue and organ function renewal. In human heart failure, this effect could have both cardiac and systemic vascular implications. The mechanism(s) of action by which MSCs exert favorable cardiovascular effects in human heart failure remain controversial. As heart failure is associated with endothelial dysfunction, impaired neovascularization, and diminished endothelial progenitor cell (EPC) abundance, we tested the hypothesis that MSCs simulate circulating EPCs and flow-mediated vasodilation in patients with heart failure due to dilated cardiomyopathy. Methods: We quantified EPC-colony forming units (EPC-CFUs) from peripheral blood in patients (n=16) and healthy controls (n=6), and compared these to flow-mediated vasodilation (FMD) before and 3-months after intracardiac injection of MSCs. Pati...
The use of anthracycline at first‐line compared to alkylating agents or nucleoside analogs improves the outcome of salvage treatments after relapse in follicular lymphoma The REFOLL study by the Fondazione Italiana Linfomi
Authors: Giuseppe Rossi, Luigi Marcheselli, Alessandra Dondi, Chiara Bottelli, Alessandra Tucci, Stefano Luminari, Luca Arcaini, Michele Merli, Alessandro Pulsoni, Carola Boccomini, Benedetta Puccini, Moira Micheletti, Giovanni Martinelli, Andrea Rossi, Vittorio Ruggero Zilioli, Valentina Bozzoli, Monica Balzarotti, Silvia Bolis, Maria Giuseppina Cabras, Massimo Federico
Journal: American Journal of Hematology (2014)

Follicular lymphoma (FL) patients experience multiple remissions and relapses and commonly receive multiple treatment lines. A crucial question is whether anthracyclines should be used at first-line or whether they would be better "reserved" for relapse and whether FL outcome can be optimized by definite sequences of treatments. Randomized trials can be hardly designed to address this question. In this retrospective multi-institutional study, time-to-next-treatment after first relapse was analyzed in 510 patients who had received either alkylating agents- or anthracycline- or nucleoside analogs-based chemotherapy with/without rituximab at first-line and different second-line therapies. After a median of 42 months, median time-to-next-treatment after relapse was 41 months (CI95%:34-47 months). After adjustment for covariates, first-line anthracycline-based chemotherapy with/without rituximab was associated with better time-to-next-treatment after any salvage than alkylating agents-based chemotherapy with/without rituximab or nucleoside analogs-based chemotherapy with/without rituximab (HR:0.74, P = 0.027). The addition of rituximab to first-line chemotherapy had no significant impact (HR:1.22, P = 0.140). Autologs stem cell transplantation performed better than any other salvage treatment (HR:0.53, P < 0.001). First-line anthracycline-based chemotherapy significantly improved time-to-next-treatment even in patients receiving salvage autologs stem cell transplantation (P = 0.041). This study supports the concept that in FL previous treatments significantly impact on the outcome of subsequent therapies. The outcome of second-line treatments, either with salvage chemoimmunotherapy or with autologs stem cell transplantation, was better when an anthracycline-containing regimen was used at first-line.
Abstract 14058: Intramural Ventricular Septal Defects After Repair of Conotruncal Anomalies Are Associated With Postoperative Morbidity
Authors: Jyoti K Patel, Reena M Ghosh, Andrew C Glatz, Chitra Ravishankar, Christopher E Mascio, Thomas L Spray, Meryl S Cohen
Journal: Circulation (2014)

Introduction: Intramural ventricular septal defects (VSDs) are tunnel-like communications between a great artery and right ventricular free wall trabeculations that can occur after repair of conotruncal anomalies. We sought to assess the prevalence of residual intramural VSDs and their impact on postoperative course. Methods: We reviewed all patients at our institution who underwent biventricular repair of a conotruncal anomaly involving VSD baffle to a great artery from the left ventricle from 1/1/11 to 6/30/13. Perioperative echocardiographic images were reviewed for residual intramural or non-intramural VSDs. The primary outcome was a composite of ECMO use, cardiac transplantation, or mortality. Secondary outcomes included hospital length of stay (LOS) and need for repeat catheter-based or surgical VSD closure. Results: Of 158 total subjects, 92 (58%) were male and diagnoses were tetralogy of Fallot (n=111), d-transposition of the great arteries (14), truncus arteriosus (13) and other (20). Median age at surgery was 51 days (IQR 6,107). Residual VSD was present in 111 subjects; 29 (26%) had an intramural defect, and 82 (74%) had non-intramural defects (71 peripatch defects, 6 small muscular defects, and 5 with both). Of the non-intramural VSDs, 79 (96%) were hemodynamically insignificant lesions (&lt;2mm). Residual intramural VSDs were more likely than non-intramural VSDs to be greater than 2mm (48% vs 4%, p&lt;0.001). There was no difference in weight, age at operation, or type of conotruncal anomaly based on type of residual VSD. The primary composite outcome was more prevalent in subjects with residual intramural defects compared to non-intramural defects (5/29 [17%] vs 4/82 [5%], p = 0.05). In addition, subjects with residual intramural VSDs had longer LOS (24 days [IQR 13,67] vs 11 days [IQR 5,23], p=0.002). The rates of repeat catheter-based or surgical closure were low overall but higher in subjects with intramural VSDs (8/29 [28%] vs 5/82 [6%], p=0.005). Conclusions: Intramural VSDs are common after repair of conotruncal anomalies and tend to be larger than non-intramural VSDs. Although most subjects still have favorable outcome, intramural VSDs are associated with greater postoperative morbidity, longer LOS, and need for reintervention.
DIAGNOSIS AND SURGICAL TREATMENT OF MENIERE'S DISEASE (HYDROPS OF LABYRINTH)
Authors: Kenneth M. Day
Journal: Annals of Internal Medicine (1945)

Article1 July 1945DIAGNOSIS AND SURGICAL TREATMENT OF MENIERE'S DISEASE (HYDROPS OF LABYRINTH)KENNETH M. DAY, M.D.KENNETH M. DAY, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-23-1-41 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptIn 1861 Ménière first described the syndrome which bears his name. It is characterized by recurring attacks of vertigo accompanied by tinnitus, deafness and, sometimes, nausea and vomiting. Another term is "Ménière's symptom complex."There are a number of conditions in which the Ménière syndrome may be present, as for example, catarrhal or suppurative middle ear disturbances, allergy, hemorrhage or thrombosis of labyrinthine vessels, toxic neurolabyrinthitis, multiple sclerosis, neurosyphilis, arteriosclerosis of the cerebral vessels and neoplasms. However, there remains a large group of cases exhibiting the syndrome that show no evidence of vascular, inflammatory or neoplastic processes involving the labyrinth,...Bibliography1. CAWTHORNE JE: The treatment of Ménière's disease, Jr. Laryngol. and Otol., 1943, lviii, 363. CrossrefGoogle Scholar2. HALLPIKECAIRNS CSH: Observations on pathology of Ménière's syndrome, Jr. Laryngol. and Otol., 1938, liii, 625. CrossrefGoogle Scholar3. PORTMANN G: The saccus endolymphaticus and an operation for draining the same for the relief of vertigo, Jr. Laryngol., 1927, xlii, 809. CrossrefGoogle Scholar4. PUTNAM TJ: Treatment of recurrent vertigo by subtemporal destruction of the labyrinth, Arch. Otolaryngol., 1938, xxvii, 161. CrossrefGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Pittsburgh, Pennsylvania*Delivered before a Regional Meeting of the American College of Physicians, Pittsburgh, Pennsylvania, November 11, 1944. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byLIII Electrocoagulation of the Membranous LabyrinthMénière's disease 1 July 1945Volume 23, Issue 1Page: 41-47KeywordsAllergy and immunologyDeafnessEdemaHemorrhageMultiple sclerosisNauseaThrombosisTinnitusVertigoVomiting ePublished: 1 December 2008 Issue Published: 1 July 1945 PDF downloadLoading ...