tbuckley/cabot-search huggingface dataset:
Abstract 3082: Exploring LIN28 mRNA targets in breast cancer cells
Authors: Jun Yang, Harriet H. Kinyamu, Trevor K. Archer
Journal: Cancer Research (2011)

Abstract LIN28 is a RNA binding protein and a pluripotency factor. It represses tumor suppressing microRNA let-7 and thus derepresses let-7 oncogene targets such as HMGA2, K-Ras and c-Myc. In addition, LIN28 binds and enhances translation of IGF-2 mRNA a known mitogen. Recent reports show that LIN28 overexpression promotes tumor cell migration and cellular transformation through repression of let-7, and that overexpression is associated with advanced stages of disease, including breast cancer. Despite the apparent critical role in cancer, the molecular function and mode of action of LIN28 is not yet elucidated. To further understand the function of LIN28, we explored LIN28 mRNA targets in breast cancer cells using RNA-protein immunoprecipitation (RIP-Chip) followed by RNA sequencing. Using RIP-Chip and RNA sequencing we have identified a number of novel LIN28 targets in MCF-7 breast cancer cells. Therapeutic drugs inhibiting LIN28 could be promising in treatment of cancer. Our experiments also demonstrate that MG132, a proteasome inhibitor, inhibits LIN28 expression and modulates expression of LIN28 mRNA targets in breast cancer cells. The mechanism by which LIN28 regulates its targets is unknown; however, a number of the new targets are important in cancer. Previous studies suggest that LIN28 acts through translational mechanisms. Studies are ongoing to reveal the mechanisms by which LIN28 regulates bound targets and how proteasome inhibitors impact this regulation. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 102nd Annual Meeting of the American Association for Cancer Research; 2011 Apr 2-6; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2011;71(8 Suppl):Abstract nr 3082. doi:10.1158/1538-7445.AM2011-3082
Vasectomy—A Note of Concern: Reprise
Authors: Hugh H. Hussey
Journal: JAMA (1981)

The title of my comments derives from Harold Lear's editorial, published inThe Journalalmost a decade ago.<sup>1</sup>Since Lear wrote, additional signs of concern have appeared, including the article in this issue by Walker and his colleagues (p 2315). In a carefully controlled study, Walker et al report causes for hospitalization of vasectomized men, compared with hospitalization for the same ailments in men who had not undergone vasectomy. Disorders of the genitourinary system constituted the only category in which hospitalization incidences were significantly greater in the vasectomized men than in the control population. However, the disorders included epididymitis and orchitis (well known though infrequent postvasectomy complications) and benign prostatic hypertrophy, redundant prepuce, phimosis, and other diseases of the male genitals. The authors wisely observe that the latter four conditions probably had been discovered when clients applied for vasectomy and that these conditions were not attributable to the operation
Comparison of real‐time microvascular abnormalities in pediatric and adult sickle cell anemia patients
Authors: Anthony T.W. Cheung, Joshua W. Miller, Sarah M. Craig, Patricia L. To, Xin Lin, Sandra L. Samarron, Peter C.Y. Chen, Theodore Zwerdling, Ted Wun, Chin‐Shang Li, Ralph Green
Journal: American Journal of Hematology (2010)

The conjunctival microcirculation in 14 pediatric and eight adult sickle cell anemia (SCA) patients was studied using computer-assisted intravital microscopy. The bulbar conjunctiva in SCA patients in both age groups exhibited a blanched/avascular appearance characterized by decreased vascularity. SCA patients from both age groups had many of the same abnormal morphometric [vessel diameter, vessel distribution, morphometry (shape), tortuosity, arteriole:venule (A:V) ratio, and hemosiderin deposits] and dynamic [vessel sludging/sludged flow, boxcar blood (trickled) flow, and abnormal flow velocity] abnormalities. A severity index (SI) was computed to quantify the degree of vasculopathy for comparison between groups. The severity of vasculopathy differed significantly between the pediatric and adult patients (SI: 4.2 ± 1.8 vs. 6.6 ± 2.4; P = 0.028), indicative of a lesser degree of overall severity in the pediatric patients. Specific abnormalities that were less prominent in the pediatric patients included abnormal vessel morphometry and tortuosity. Sludged flow, abnormal vessel distribution, abnormal A:V ratio, and boxcar flow appeared in high prevalence in both age groups. The results indicate that SCA microvascular abnormalities develop in childhood and the severity of vasculopathy likely progresses with age. Intervention and effective treatment/management modalities should target pediatric patients to ameliorate, slow down, or prevent progressive microvascular deterioration.
Adjuvant Therapy for Pancreatic Cancer
Authors: Al B. Benson
Journal: JAMA (2007)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Beta 2-adrenergic receptor and angiotensin II receptor modulation of sympathetic neurotransmission in human atria.
Authors: L C Rump, E Schwertfeger, U Schaible, G Fraedrich, P Schollmeyer
Journal: Circulation Research (1994)

The aim of the present study was to investigate beta-adrenergic receptor and angiotensin II (Ang II) receptor modulation of norepinephrine release in human atria. Slices of human atrial appendages were incubated with [3H]norepinephrine, superfused with Krebs-Henseleit solution, and electrically stimulated in superfusion chambers. Pretreatment of the tissue with 6-hydroxydopamine (1.2 mmol/L) before the [3H]norepinephrine incubation to destroy sympathetic nerves reduced the uptake of radioactivity and abolished the stimulation-induced (S-I) outflow of radioactivity. Furthermore, S-I outflow of radioactivity was prevented by the addition of tetrodotoxin (1 mumol/L) to and omission of extracellular Ca2+ from the superfusion solution. Separation of [3H]norepinephrine from its metabolites revealed that the S-I outflow of radioactivity was mainly composed of intact [3H]norepinephrine. Thus, the S-I outflow of radioactivity was taken as an index of norepinephrine release. Isoproterenol (0.001 to 0.1 mumol/L) dose-dependently enhanced the S-I outflow of radioactivity. The concentration-response curve of isoproterenol was shifted to the right by the selective beta 2-adrenergic receptor antagonist ICI 118551 (0.01 and 0.1 mumol/L) but not by the beta 1-adrenergic receptor-selective antagonist atenolol (0.3 and 30 mumol/L). Ang II (0.001 to 1.0 mumol/L) also dose-dependently enhanced S-I outflow of radioactivity. The facilitatory effect of Ang II was blocked by either the peptide Ang II receptor antagonist saralasin (1.0 mumol/L) or EXP 3174 (0.1 mumol/L), the in vitro active form of the nonpeptide Ang II receptor antagonist losartan. The cell-permeable cAMP analogue 8-bromo-cAMP (30 to 300 mumol/L) dose-dependently enhanced S-I outflow of radioactivity.(ABSTRACT TRUNCATED AT 250 WORDS)
"CANCER" BY WILLY MEYER
Authors: Willy Meyer
Journal: JAMA (1931)

<h3>To the Editor:</h3> —The review of my recent book on cancer (The Journal, April 11, p. 1255) is gratefully noted. A few lines below the middle, the review quotes the book as follows: "The medical treatment should have as its object the change of the alkalosis to acidosis" and then continues: "but how this is to be accomplished is not described." Regarding this statement, may I be permitted to call attention to chapter 37, p. 396, of the book, where the following occurs: "27. How to go about producing the acidosis has been elaborated in the several chapters of Part II of this book." The chapters referred to are numbers 31 to 36, and the means for producing acidosis therein examined by discussion and by casuistics are: artificially induced fever; Coley's fluid; hunger; medication by the administration of calcium internally and externally, parathyroid tablets, acid and colors.
Pulmonary Aspiration of Gastric Acid: Mendelson's Syndrome
Authors: Hugh Johnson
Journal: JAMA (1962)

ANYONE who has vomited peptic acid secretion is acutely aware of the irritating nature of the acid. It is not difficult to visualize the effect of aspiration of gastric secretion into the lungs during general anesthesia. The characteristic syndrome produced by the aspiration of liquid gastric contents as differentiated from the syndrome of obstruction caused by aspiration of solid material was observed and described accurately by Mendelson. Thus, it deservedly should bear his name. The syndrome simulates pulmonary edema and has its abrupt onset following the aspiration of the acid contents either during or shortly following general anesthesia. There is profuse, frothy, bloody sputum, cyanosis and signs of air hunger, tachycardia, and fever. X-ray films of the chest show irregular, soft, mottled densities in the involved lung areas. These are the findings as reported by Mendelson and corroborated by him in experimental animals following the aspiration of 20 cc. of
Insulin responses to glucose: evidence for a two pool system in man
Authors: D. Porte, A. A. Pupo
Journal: Journal of Clinical Investigation (1969)

Four rapid glucose injections of 5 g each were administered to normal young adult subjects before, during, and after an infusion of glucose. After the first glucose pulse, insulin responses measured immunologically reached a peak between 3 and 5 min and rapidly returned to base line. A short glucose infusion of 300 mg/min decreased the rapid insulin response to a second glucose pulse (- 58%), but after a longer infusion (20 hr) the acute insulin response to a third pulse was restored to normal. Stopping the infusion was followed by return of glucose and insulin levels to prestudy base line within 1 hr, but a fourth glucose pulse was followed by a supernormal acute insulin response (+ 200%). Other observations during these studies showed that a short glucose infusion of either 100 mg/min or 300 mg/min produced a parallel rise in glucose and insulin, but continuation of the infusion for 20 hr was associated with a "paradoxical" fall in glucose and continued rise in insulin. These observations are considered incompatible with a simple linear model often used to describe the relation between plasma glucose and serum insulin. Instead, a two pool system—one for acute insulin release, and the other a time-dependent compartment for long term insulin responses—is suggested.
Geometry of Left Ventricular Contraction in the Systolic Click Syndrome
Authors: A. JAMES LIEDTKE, JAMES H. GAULT, DAVID M. LEAMAN, MELVIN S. BLUMENTHAL
Journal: Circulation (1973)

Left ventricular (LV) shape change during systole was characterized in nine patients with typical clinical findings of the systolic click syndrome (SCS) by means of cineangiographic measurements of three segmental diameters of the LV cavity and of the mitral valve ring (MVR) and contrasted with findings in eight patients with normal LV function. In the latter group, shortening of the proximal, midventricular, and apical segment diameters was comparable, averaging 38.6, 40.3, and 46.8%, respectively; MVR shortening averaged 31.8%. The velocity of fiber shortening, estimated as mean circumferential fiber shortening rate (mean FSR), was also similar in the three segments (1.66, 1.84, and 2.09 circ/sec). In patients with SCS, the extent of shortening and mean FSR in the proximal ventricular segment were consistently reduced (average 22.2%, P &lt; 0.005; and 0.96 circ/sec, P &lt; 0.025 respectively), and the MVR exhibited either reduced extent of contraction (four patients) or was unchanged or increased in diameter during systole (five patients). However, shortening of the midventricular and apical segments was normal, averaging 37.5 and 40.5%, respectively, as was the mean FSR in these segments (averages 1.60 and 1.70 circ/sec). These findings are consistent with a primary disorder of the myocardium in SCS localized to the inflow region of the left ventricle.
ACNE VULGARIS FOLLOWING THE TAKING OF YEAST
Authors: H. H. Hazen
Journal: JAMA (1933)

To the Editor:  —Despite the marvelous accounts of the value of yeast, written by the advertising agents of the yeast companies and supported by the foreign legion of physicians, the relative percentage of acne cases among dermatoses has not decreased. In addition, at least half of the patients suffering from acne have previously tried yeast without any benefits to themselves. But that the administration of yeast may actually induce the appearance of acne vulgaris seems to have escaped attention. The report of the following three cases of acne is of some passing interest:  Case 1.  —A white man, aged 26, had suffered from a mild acne between the ages of 16 and 20 but had been entirely well for six years. Because of some indigestion he decided to take yeast, and after he had done so for three weeks there was no change in his gastro-intestinal condition and, in addition,
Do Life Events or Depression Exacerbate Inflammatory Bowel Disease?
Authors: Carol S. North, David H. Alpers, John E. Helzer, Edward L. Spitznagel, Ray E. Clouse
Journal: Annals of Internal Medicine (1991)

Objective: To determine whether depressed mood or life events are associated with an exacerbation of inflammatory bowel disease. Design: A prospective study of a consecutive sample of patients with relapsing inflammatory bowel disease, followed by monthly questionnaires and periodic office visits. Setting: A referral-based gastroenterology clinic at a medical school. Patients: A consecutive sample of 32 patients with inflammatory bowel disease who had had at least one relapse in a 2-year period after entry into the study. Measurements and Main Results: The Social Readjustment Rating Scale (measuring life events), the Beck Depression Inventory (a visual analog scale for depressed mood) and an inventory of intestinal symptoms were completed monthly by each subject with a 78% rate of compliance. A mean of 2.2 exacerbations was seen per subject during the study period. Life events were not temporally associated with changes in intestinal symptoms. Significant associations were found between intestinal symptoms and the two mood scales (P < 0.05 for each), but no directionality in symptom occurrence could be detected in a time-lagged analysis. The results were similar when the months preceding exacerbations of inflammatory bowel disease were analyzed separately. Conclusions: Although these findings suggest that mood changed concurrently with exacerbation of inflammatory bowel disease, no evidence indicated that stressful life events or depressed mood precipitated exacerbations in this study group.
Spirituality in Patient Care: Why, How, When, and What
Authors: Pat Fosarelli
Journal: JAMA (2008)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Allelic imbalance in CALR somatic mutagenesis
Authors: A S Harutyunyan, R Jäger, D Chen, T Berg, E Rumi, B Gisslinger, D Pietra, H Gisslinger, M Cazzola, R Kralovics
Journal: Leukemia (2015)

We cannot rule out the possibility of occult disease influencing some of our findings, particularly for indolent malignancies such as CLL.Indeed, we observed strong sCD23 associations for CLL/SLL diagnosed closer in time to phlebotomy, which may be at least partly disease induced, as circulating sCD23 in CLL patients has been associated with tumor burden. 14However, our sCD23 findings for the more aggressive DLBCL are consistent with etiologic effects, given the consistency in associations across follow-up periods and especially the strong risk present even among cases diagnosed 15-23 years after phlebotomy.The weaker NHL associations for sCD27 and sTNFR2 ⩾ 8 years postphlebotomy may reflect diseaseinduced effects, odds ratio attenuation due to a decline in representativeness of one-time analyte measurements as surrogates for usual levels, or both.The generalizability of these findings is questionable, given that the study population consisted entirely of male Finnish heavy smokers.However, similar NHL and subtype associations with sCD23 and sCD30 have previously been reported, although with fewer years of follow-up, in population-based cohorts that include women (including one all-female cohort) and non-smokers. 3,4,6 Our findings raise the possibility that serum sCD23 and sCD30 may hold promise as surrogate end points for cross-sectional studies of suspected B-cell-stimulative risk factors.It is also possible, although speculative, that these markers may have future clinical value in developing risk prediction models.In particular, given the strong association with the CLL/SLL risk observed for elevated sCD23 in serum collected ⩽ 15 years before diagnosis, there is a need to investigate whether the elevated levels of this marker are predictive of future progression to CLL among patients with monoclonal B-cell lymphocytosis, an asymptomatic precursor condition to this malignancy. 15Studies addressing these questions, particularly using serially collected specimens, are warranted.
Initiating angiotensin converting enzyme inhibitors in mild to moderate heart failure in general practice: randomised, placebo controlled trial
Authors: M. Lough, J. Cleland, J. Langan, A. Cowley, A. Wade
Journal: BMJ (1998)

study, in which the positive association between childhood energy intake and subsequent risk of cancer was also confined to cancers unrelated to smoking. 2 Most previous studies have either grouped all cancers together or looked only at individual cancers.However, consistent with our results, the physicians health study found a positive association of height with all malignant neoplasms but not with lung cancer. 5 In line with extensive animal experimental evidence, 1 therefore, our data and those from the Boyd Orr study 2 suggest that energy intake during growth may be an important determinant of later risk of developing cancer.Since height serves as only an indirect and comparatively weak proxy measure of dietary intake in childhood, the size of the association found in this study may reflect a much stronger underlying association with directly measured childhood energy intake.
Opacification and border delineation improvement in patients with suboptimal endocardial border definition in routine echocardiography: Results of the phase III albunex multicenter trial
Authors: Linda J. Crouse, Jorge Cheirif, Denise E. Hanly, Joseph A. Kisslo, Arthur J. Labovitz, Joel S. Raichlen, Ronald W. Schutz, Pravin M. Shah, Mikel D. Smith
Journal: Journal of the American College of Cardiology (1993)
Imatinib Mesylate as Add-on Therapy for Pulmonary Arterial Hypertension
Authors: Marius M. Hoeper, Robyn J. Barst, Robert C. Bourge, Jeremy Feldman, Adaani E. Frost, Nazzareno Galié, Miguel Angel Gómez-Sánchez, Friedrich Grimminger, Ekkehard Grünig, Paul M. Hassoun, Nicholas W. Morrell, Andrew J. Peacock, Toru Satoh, Gérald Simonneau, Victor F. Tapson, Fernando Torres, David Lawrence, Deborah A. Quinn, Hossein-Ardeschir Ghofrani
Journal: Circulation (2013)

By its inhibitory effect on platelet-derived growth factor signaling, imatinib could be efficacious in treating patients with pulmonary arterial hypertension (PAH).Imatinib in Pulmonary Arterial Hypertension, a Randomized, Efficacy Study (IMPRES), a randomized, double-blind, placebo-controlled 24-week trial, evaluated imatinib in patients with pulmonary vascular resistance ≥ 800 dyne·s·cm(-5) symptomatic on ≥ 2 PAH therapies. The primary outcome was change in 6-minute walk distance. Secondary outcomes included changes in hemodynamics, functional class, serum levels of N-terminal brain natriuretic peptide, and time to clinical worsening. After completion of the core study, patients could enter an open-label long-term extension study. Of 202 patients enrolled, 41% patients received 3 PAH therapies, with the remainder on 2 therapies. After 24 weeks, the mean placebo-corrected treatment effect on 6-minute walk distance was 32 m (95% confidence interval, 12-52; P=0.002), an effect maintained in the extension study in patients remaining on imatinib. Pulmonary vascular resistance decreased by 379 dyne·s·cm(-5) (95% confidence interval, -502 to - 255; P<0.001, between-group difference). Functional class, time to clinical worsening, and mortality did not differ between treatments. Serious adverse events and discontinuations were more frequent with imatinib than placebo (44% versus 30% and 33% versus 18%, respectively). Subdural hematoma occurred in 8 patients (2 in the core study, 6 in the extension) receiving imatinib and anticoagulation.Imatinib improved exercise capacity and hemodynamics in patients with advanced PAH, but serious adverse events and study drug discontinuations were common. Further studies are needed to investigate the long-term safety and efficacy of imatinib in patients with PAH.URL: http://www.clinicaltrials.gov. Unique identifier: NCT00902174 (core study); NCT01392495 (extension).
Idiopathic Retroperitoneal Fibrosis
Authors: Benedict R. Harrow
Journal: JAMA (1962)

The etiology of idiopathic retroperitoneal fibrosis is unknown. The condition manifests itself at first by vague abdominal discomfort. Diagnosis is important because a majority of these patients will recover by preserving renal function using ureteral lysis or occasionally by diversion procedures. Occlusion ureterograms are most important in evaluating the disease. Many other diseases can mimic idiopathic retroperitoneal fibrosis and can only be distinguished by generous biopsies taken at operation. One patient with idiopathic retroperitoneal fibrosis, a man aged 72, needed a second operation with intraperitoneal lysis of both ureters before an apparent cure resulted. A second patient, a woman aged 52, obtained a dramatic result following x-ray therapy. The variable and capricious course the disease may run requires frequent follow-up examinations over many years.