tbuckley/cabot-search huggingface dataset:
Lymphocytic Hypophysitis of Pregnancy Resulting in Hypopituitarism: A Distinct Clinicopathologic Entity
Authors: SYLVIA L. ASA
Journal: Annals of Internal Medicine (1981)

Two patients presented with abnormalities suggestive of pituitary adenoma; one during pregnancy and one in the postpartum period. However, pathologic examination of the pituitary showed extensive destruction by a lymphoplasmacytic infiltrate; no tumor was identified. Both patients developed hypopituitarism. We know of eight additional cases of lymphocytic hypophysitis, seven of which have been reported in the literature. In only three cases, including the two reported here, the diagnosis was established by biopsy. In each of those cases, the entity mimicked a pituitary tumor. This is the first report of electron microscopy of this lesion and the ultrastructural features support the previously suggested autoimmune etiology. The lesion has been described only in women and seven of ten patients were pregnant or postpartum at the onset. This fact and previously reported experimental evidence, including the identification of anti-prolactin cell antibodies, support our suggestion that lymphocytic hypophysitis associated with pregnancy represents a distinct clinicopathologic entity.
STRANGULATED HERNIA: SOME PRACTICAL REMARKS CONCERNING ITS DIAGNOSIS AND ITS PROPER MANAGEMENT.
Authors: PARKER SYMS
Journal: JAMA (1900)

Strangulated hernia presents too important a subject to be comprehensively set forth in a brief essay, therefore the scope of this paper has been limited to the entirely practical and clinical features. No attempt has been made to minutely describe the pathic anatomy of the condition, nor to review the theories of the etiology of strangulation of a hernia. Broad rules have been treated as being invariable; the exceptions have not been dwelt on. An incarcerated hernia is one in which the contents of the bowel involved are so included as to prevent their passage or escape, but in which the blood circulation is not materially impeded. A strangulated hernia, on the other hand, is one in which the constriction is sufficient to shut off the blood circulation of the part involved. For the practical purposes of this paper it may be stated that strangulation of a hernia depends on
Public Pressure Ends 'Bundled' Drug Program, But How Much Cost Will Drop Remains Unclear
Authors: Paul Cotton
Journal: JAMA (1991)

ANTITRUST SUITS and acts of Congress have pressured the Sandoz Pharmaceuticals Corp of East Hanover, NJ, into "unbundling" its powerful schizophrenia drug clozapine (Clozaril). The change "should make this breakthrough therapy far more widely available," says David Winter, MD, vice president for scientific and external affairs at Sandoz. Whether clozapine will get to the majority of patients who could benefit but now cannot afford it is still unclear. Despite its ability to turn some institutionalized patients into productive citizens, only about 7000 people in the United States are taking it. The "no blood, no drug" rule remains, requiring weekly blood tests for agranulocytosis, a potentially fatal side effect seen in up to 2% of patients. But these tests and distribution of the drug will no longer be done solely by Caremark Homecare Inc of Lincolnshire, Ill. Many state Medicaid programs do not cover clozapine because the bundled, Caremark package costs
Effect of radiofrequency ablation for the local recurrent lesion of hepatocellular carcinoma after non-surgical treatment
Authors: Koichi Haruyama, Akiko Saito, Hideki Nozawa, Kenji Hanada, Masami Kikuzato, Hiroaki Okuda, Naoaki Hayashi, Satoshi Katagiri, Hideo Katuragawa, Ken Takasaki
Journal: Journal of Hepatology (2002)
Relationship between Summertime Ambient Ozone Levels and Emergency Department Visits for Asthma in Central New Jersey
Authors: Clifford P. Weisel, Ronald P. Cody, Paul J. Lioy
Journal: Environmental Health Perspectives (1995)

The 5-year retrospective study of the association between temperature and emergency department (ED) visits for asthma with mean ambient ozone levels between 10:00 and 15:00 was conducted in central New Jersey during the summer months.An association was identified in each of the years (1986)(1987)(1988)(1989)(1990).Between 8 and 34% of the total variance in ED visits for asthma was explained by the two environmental variables in the step-wise multiple regression analysis.ED visits occurred 28% more frequently when the mean ozone levels were >0.06 ppm than when they were < 0.06 ppm.This result was statistically significant in a covariance analysis.An evaluation of the effects of ozone on asthmatics reported in the literature was completed to determine if, as proposed by Bates, the results from different types of studies were coherent among the health metrics.A consistency in the magnitude of reported effects and the time lag between exposure and response for four different health indices (symptom reports, decrements in expiratory flow, ED visits, and hospital admissions) was identified and indicates a coherence between ozone and respiratory response to ozone exposure.This supports a proposition that ozone adversely affects asthmatics at levels below the current U.S. standard.
A "Mill" Graduate in Indiana.
Authors: J. O. Malsbury
Journal: JAMA (1897)

Peru, Ind., Feb. 8, 1897. <h3>To the Editor:</h3> —I see in theJournalof February 6, a reference to the Illinois Health University, now Independent Medical College, of which one J. Armstrong is president, secretary, treasurer, etc. We have had here a little experience with one or more of his graduates, one Dr. Elmor (?) who struck our town last summer, with long hair, a good supply of cheek, but little money and glowing advertisements, prepared as he thought to bluff everything in sight; but for once he overlooked his hand. We made him lie down, shut up, and get out, as we have all other advertising quacks of similar qualifications, coming to our town. If you will send J. Armstrong and his college down to Peru, we will turn his college into a hospital and make him the leading patient. My idea about his college is to suppress his graduates,
Chronic eosinophilic pneumonia associated with cutaneous T-cell lymphoma
Authors: Boaz Hirshberg, Mordechai R. Kramer, Michal Lotem, Vivian Barak, Larisa Shustin, Gail Amir, Dina Ben-Yehuda, Arie Ben-Yehuda
Journal: American Journal of Hematology (1999)

Cutaneous T-cell lymphomas (CTCL) are diseases characterized by cutaneous infiltrates of malignant clonally expanded T cells. CTCL cells exhibit a cytokine profile consistent with T helper-2 type (TH2) cells. Eosinophilic pneumonias are individual syndromes characterized by eosinophilic pulmonary infiltrates and commonly peripheral blood eosinophilia. CTCL and chronic eosinophilic pneumonia are rare clinical entities. We report a patient with the association of CTCL and chronic eosinophilic pneumonia. To understand the mechanism leading to the eosinophilia, we examined the patient's cytokine profile. This was consistent with a high TH2 activity. Her interleukin (IL) 5, 6, and 10 levels were extremely high, while her IL-2 and interferon-γ (IFN-γ) levels (TH1 profile) were low. We believe that eosinophilic pneumonia in this patient is probably secondary to high TH2 cytokine levels induced by tumor cells. We suggest that eosinophilic pneumonia should be considered as a possible diagnosis in patients with CTCL who have respiratory complaints. Am. J. Hematol. 60:143–147, 1999. © 1999 Wiley-Liss, Inc.
Breakdown of proteoglycan and collagen induced in pig articular cartilage in organ culture.
Authors: J T Dingle, P Horsfield, H B Fell, M E Barratt
Journal: Annals of the Rheumatic Diseases (1975)

Explants of articular cartilage from young pigs were maintained in organ culture for 10--16 days, and degradation of matrix was induced by retinol or complement-sufficient antiserum. The percentage breakdown of proteoglycan and collagen (as hydroxyproline release) was measured. The response of the cartilage depended on whether or not the explants were cut so as to include some of the invading marrow ('invasion zone'). In media containing retinol, cartilage lost up to three-quarters of its proteoglycan whether the invasion zone was present or not, but very little of its collagen unless this region was included. In the presence of complement-sufficient anti-serum, however, cartilage without the invasion zone was virtually unaffected, but both proteoglycan and hydroxyproline were released when invasion zone was included; here proteoglycan release began almost immediately, but there was a time-lag of 6--8 days before a substantial amount of hydroxyproline appeared in the medium. Histological examination of sample explants from the experiments supported the biochemical findings. The possible significance of the results in relation to rheumatoid arthritis is discussed.
Mary Ann Christina Adams
Authors: Henry Maas
Journal: BMJ (2007)

Mary Ann Christina Adams, who died on 17 September aged 98, was a greatly respected and much loved general practitioner whose career spanned the decades from the 1930s to the 1980s. 

Born in 1908 and educated in Felixstowe, she trained and practised in London. After some years working with Joan Malleson she started her own practice …
STUDIES ON BARTONELLA MURIS ANEMIA
Authors: J. Marmorston-Gottesman, David Perla
Journal: The Journal of Experimental Medicine (1931)

In Bartonella muris carrier stock certain changes are observed in the lymphoblastic and reticular and endothelial elements after splenectomy and recovery from the anemia. These changes appear 3 to 5 months after splenectomy and are associated with immunity to further infection with Bartonella muris. The changes consist primarily of hyperplasia of hemolymph tissue, hyperplasia of reticular and endothelial elements of lymph nodes, the formation of lymphoblastic foci periportally in the liver and peribronchially and perivascularly in the lung, regeneration of all elements of the thymus and marked hyperplasia of all elements of the bone marrow (increased hematopoiesis).
On a 'Residual-Air-Pump' for Emphysema
Authors: H. Dobell
Journal: BMJ (1872)

Feb. io, i872potash of Class No. iII or effete material; as, while in muscular tissue these two substances occur precisely in the right proportions to form pyrophosphate of potash (a very remarkable and interesting result), no such proportion is found to exist between the two corresponding sub- stances in pulmonary tissue, which is clearly shown thus.Mluscular Tissue.Pulmonary Tissue.Theory.Phosphoric acid.. (o.563) 42.4* (0.058) II.4 43 ) Pyroph. of Potash.(0.764) 57.6 (0.45J) 88.6 575 potash.100.0 100.0 100 * The proportions per cent. of phosphoric acid and potash effete in the four analyses of muscular tissue were as follows:
Swiss experience of managed care
Authors: T. V Perneger, J.-F. Etter
Journal: BMJ (1997)

Editor—Chris Ham's editorial on managed care in Europe ignores the Swiss experience.1 Traditionally, Swiss citizens could see any doctor they wanted, paid the doctor on a fee for service basis, and were reimbursed by the health insurance company to which they belonged. In 1990, in an attempt to curb healthcare expenditure, the federal government authorised “health insurance contracts with limited choice of doctor” (which means health maintenance organisations minus the political marketing wrapping), and this option remained in the new Law on Health Insurance, adopted …
Mepolizumab, a Humanized Monoclonal Antibody to IL-5, for Severe Eosinophilic Esophagitis in Adults: A Randomized, Placebo-Controlled Double-Blind Trial
Authors: A STRAUMANN, S CONUS, H KITA, G KEPHART, C BUSSMANN, C BEGLINGER, J PATEL, M BYRNE, H SIMON
Journal: Journal of Allergy and Clinical Immunology (2008)
Sjögren's Syndrome in Systemic Lupus Erythematosus
Authors: DONATO ALARCÓN-SEGOVIA
Journal: Annals of Internal Medicine (1974)

Sicca features of Sjögren's syndrome were investigated in 50 unselected, consecutive patients with systemic lupus erythematosus by questioning, clinical examination, Schirmer's tests, rose bengal staining tests, secretory parotid sialography, scintillation scanning of salivary glands with 99mTc-pertechnetate, radionuclide salivary excretion studies, and histologic study of minor salivary glands of the lip. Twenty-three patients complained of sicca symptoms; of these, 16 had ocular symptoms and xerostomia. Twenty-seven patients had apparently enlarged submandibular or parotid glands. Forty-nine of the 50 patients had abnormalities in at least 2 test results. The other patient had an abnormal sialography. The minor salivary glands of the lip were altered in 47 patients. The 3 patients with normal biopsies had abnormal sialographies or scintiscans, or both. The clinical or subclinical evidence of Sjögren's syndrome in practically all patients with lupus erythematosus may have important theoretical implications regarding the role, whether passive or active, of the lacrimal and salivary glands in autoimmunity.
Benjamin Rush's Lectures on the Mind
Authors: Guenter B. Risse
Journal: JAMA (1981)

The editors have furnished readers with a complete version of Benjamin Rush's lectures on the mind. These classes were delivered by Rush at the University of Pennsylvania between 1791 and his death in 1813. They formed part of the so-called<i>Institutes of Medicine</i>, an exposition of medical principles articulating both the human physiology and pathology that governed health and disease. The volume is provided with a general introduction containing a brief biographical sketch of Rush, the man and teacher, followed by an essay on the 18th-century<i>Institutes of Medicine</i>tradition and their relationship to psychology. While including mental faculties and operations in these lectures, Rush recognized the impossibility of explaining them neurophysiologically. According to the editors, he was a follower of David Hartley (1705-1757), the English philosopher and physician who founded associational psychology. A perceptive commentary on the unity and peculiarity of Rush's thought that embraced Christianity, republicanism, morality, and
Mosaic-Patterned and Scalloped Duodenal Mucosa in Whipple's Disease
Authors: Franco Armelao, Federica Portolan, Roberto Togni
Journal: Clinical Gastroenterology and Hepatology (2008)

A 67-year-old woman was admitted to the hospital for evaluation of a 2-year history of a 30-kg unintentional weight loss, fatigue, arthralgia, nonbloody diarrhea, and iron-deficiency anemia. She denied abdominal pain, fever, or vomiting. Her hemoglobin level was 9.0 g/dL with mean corpuscular volume of 66 fL; the erythrocyte sedimentation rate was 100 and serum albumin levels were 2.9 g/dL. Endomysial and tissue transglutaminase antibodies were negative and total immunoglobulin A levels were normal. She underwent esophagogastroduodenoscopy that revealed subtle mucosal changes; mosaic-patterned duodenal mucosa with mucosal grooves and minimal scalloped folds was observed (Figure A); small-bowel specimens showed villous atrophy and infiltration of macrophages into lamina propria containing intracellular periodic acid-Schiff–positive granules (Figure B and inset). Computerized tomography showed multiple enlarged subcentimeter mesenteric lymph nodes. Trimethoprim/sulfamethoxazole was started and resulted in weight gain and resolution of her symptoms after 6 months of treatment. Malabsorption can be caused by a wide variety of small intestinal mucosal diseases. Although celiac disease is the most common cause of chronic malabsorption in Western countries and subtle endoscopic mucosal changes might suggest celiac disease in our patient, Whipple's disease may show these endoscopic features, too.1Shah V.H. Rotterdam H. Kotler D.P. et al.All that scallops is not celiac disease.Gastrointest Endosc. 2000; 51: 717-720Abstract Full Text Full Text PDF PubMed Scopus (113) Google Scholar Small-bowel histology is probably the most crucial part of the diagnostic process.2Babbin B.A. Crawford K. Sitaraman S.V. et al.Malabsorption work-up: utility of small bowel biopsy.Clin Gastroenterol Hepatol. 2006; 4: 1193-1998Abstract Full Text Full Text PDF PubMed Scopus (19) Google Scholar
The Surgical Treatment of Cerebrovascular Disease
Authors: Robert G. Ojemann
Journal: New England Journal of Medicine (1966)

THE past decade has witnessed a remarkable evolution in the surgical treatment of cerebrovascular disease. This has been accomplished by a combination of important developments, which have included the refinement of diagnostic cerebral angiography, improvement of surgical technics, discovery of drugs for effective control of cerebral edema and better understanding of clinical and pathologic processes.The purpose of this progress report is to present the current status of surgical evaluation and treatment for each major category of cerebrovascular disease so that those not regularly exposed to the neurologic and neurosurgical specialties may better understand the benefits now offered. Emphasis is . . .
Use of Placebo in a Trial of Thalidomide for Pediatric Crohn Disease
Authors: Wael El-Matary
Journal: JAMA (2014)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Treatment of In-Stent Restenosis With Excimer Laser Coronary Angioplasty Versus Rotational Atherectomy
Authors: Roxana Mehran, George Dangas, Gary S. Mintz, Ron Waksman, Alexandre Abizaid, Lowell F. Satler, Augusto D. Pichard, Kenneth M. Kent, Alexandra J. Lansky, Gregg W. Stone, Martin B. Leon
Journal: Circulation (2000)

Background —Atheroablation yields improved clinical results for balloon angioplasty (percutaneous transluminal coronary angioplasty, PTCA) in the treatment of diffuse in-stent restenosis (ISR). Methods and Results —We compared the mechanisms and clinical results of excimer laser coronary angioplasty (ELCA) versus rotational atherectomy (RA), both followed by adjunct PTCA; 119 patients (158 ISR lesions) were treated with ELCA+PTCA and 130 patients (161 ISR lesions) were treated with RA+PTCA. Quantitative coronary angiographic and planar intravascular ultrasound (IVUS) measurements were performed routinely. In addition, volumetric IVUS analysis to compare the mechanisms of lumen enlargement was performed in 28 patients with 30 lesions (16 ELCA+PTCA, 14 RA+PTCA). There were no significant between-group differences in preintervention or final postintervention quantitative coronary angiographic or planar IVUS measurements of luminal dimensions. Angiographic success and major in-hospital complications with the 2 techniques were also similar. Volumetric IVUS analysis showed significantly greater reduction in intimal hyperplasia volume after RA than after ELCA (43±14 versus 19±10 mm 3 , P &lt;0.001) because of a significantly higher ablation efficiency (90±10% versus 76±12%, P =0.004). However, both interventional strategies had similar long-term clinical outcome; 1-year target lesion revascularization rate was 26% with ELCA+PTCA versus 28% with RA+PTCA ( P =NS). Conclusions —Despite certain differences in the mechanisms of lumen enlargement, both ELCA+PTCA and RA+PTCA can be used to treat diffuse ISR with similar clinical results.
Organising a practice. Converting to practice premises.
Authors: M J Farmer
Journal: BMJ (1982)

Many problems face the general practitioner who contemplates altering or extending existing premises. The premises may be specially purchased by a practice for use as a surgery and thus arc substantially altered to suit requirements, or those already in use as a surgery but in need of extension, modification, or refurbishment. Many general practitioners still practise from inadequate premises, which have become too small and congested owing to extended patient lists, a growing number of staff who have to cope with bureaucracy, and expanding partnerships, and these combine with changes and new attitudes to the practice of modem medicine. Thus the practice team needs to reappraise their working conditions with a view to seriously considering a building programme, helped financially by the  rent  Having made the decision to pursue a building programme, the first consideration must be a consultation with the local family practitioner administrator. Many administrators and their senior officers have considerable experience of surgery develop? ment and of the cost rent scheme set out in the Red Hook. They will advise the practice on the location and suitability of the proposed surgery. The staff of the regional medical officer are also available for informal discussions at this stage. Hy having these early consultations, the practice should at least obtain some assurance that sub)ect to submitting suitable plans and areas for the FPC to approve the project has potential. At this stage the practice team must draw up a working brief by discussing their requirements and creating a design philosophy and a series of parameters suitable to modern practice. It is important that the brief is an assessment of up-to-date methods of practice and not just a r?gurgitation of existing methods, which are probably the reasons for considering a building programme. The brief should look critically at some of the following: the organisation of consulting suites/examination rooms; facilities for trainees; treatment areas; storage of records; appointment system; reception areas waiting room; office areas office administration; computerisation of information and records; staff accommodation; special staff commitments; and as many aspects of good medical practice as can be feasibly included in the scheme.
Effects of Cimetidine on the Elimination and Actions of Ethanol
Authors: John Feely
Journal: JAMA (1982)

The influence of cimetidine hydrochloride (300 mg four times daily for seven days) on plasma ethanol concentrations and the subjective assessment of intoxication after a single oral dose of ethanol (0.8 g/kg) were investigated in a randomized double-blind placebo controlled study in six volunteers. Compared with the placebo, cimetidine produced a small increase in both the peak plasma ethanol level (from 146 +/- 5.2 to 163 +/- 7.6 mg/dL, mean +/- SEM) and th area under the ethanol concentration time curve (from 717 +/- 17 to 771 +/- 44 mg/dLXhr). In addition, using a visual analogue scale, subjects rated themselves more intoxicated at their peak of intoxication while receiving cimetidine. These results suggest that cimetidine has a small effect on the handling of ethanol in humans.