tbuckley/cabot-search huggingface dataset:
Abstract 3662: Tumor-derived interleukin-1 promotes lymphangiogenesis and lymph node metastasis through activation of M2-type macrophages by lung cancer cells
Authors: Kosuke Watari, Tomohiro Shibata, Akihiko Kawahara, Yuichi Murakami, Hiroshi Nabeshima, Ai Shinoda, Koichi Azuma, Hiroto Izumi, Masayoshi Kage, Michihiko Kuwano, Mayumi Ono
Journal: Cancer Research (2014)

Abstract Widespread metastases including lymph node have often led to the failure of cancer patient treatments. Lymph node metastasis is closely associated with lymphangiogenesis and poor prognosis in lung cancer. Identifying the molecules involved in these processes could help to advance therapeutic strategies for lung cancer patients. We have asked how cancer cells acquire malignant characteristics including lymph node metastasis and lymphangiogenesis, and also how such highly malignant tumor could be therapeutically overcome. Human malignancies are often initiated and promoted by inflammation, in close association with angiogenesis and lymphangiogenesis, while the recruitment of macrophages and neutrophils to the tumor microenvironment activates cells to support cancer progression. Interleukin (IL-1), a representative inflammatory cytokine, is often expressed in human malignancies including lung cancers with poor prognosis. In this study we examined how IL-1 promotes lymph node metastasis and lymphangiogenesis by lung cancer cell lines expressing higher IL-lα. In our present study, we observed following experimental results. [1] Tumor growth, lymph node metastasis, lymphangiogenesis and enhanced infiltration of neutrophils and macrophage were all markedly augmented by the highly metastatic cancer cells. [2] In the highly metastatic tumors, we observed higher expression of IL-1α, IL-1β and CXC chemokines by cancer cells, and also that of VEGF-A and VEGF-C by tumor-associated macrophages, respectively. These tumor-associated macrophages were found to be mainly of the M2 type. [3] Treatment with an IL-1R antagonist (IL-1Ra) significantly blocked expression of CXC chemokines by cancer cells, and also expression of VEGFs by macrophages when co-cultured with cancer cells in vitro. [4] Administration of IL-1Ra significantly suppressed tumor growth, lymph node metastasis and lymphangiogenesis, accompanying by significantly decreased infiltration of M2-type macrophage in the highly metastatic tumors. Together, targeting IL-1/IL-1R signaling pathway and/or M2-type macrophages could be expected to provide useful therapeutic strategy against lymph node metastasis by inflammatory malignant cancer cells. Citation Format: Kosuke Watari, Tomohiro Shibata, Akihiko Kawahara, Yuichi Murakami, Hiroshi Nabeshima, Ai Shinoda, Koichi Azuma, Hiroto Izumi, Masayoshi Kage, Michihiko Kuwano, Mayumi Ono. Tumor-derived interleukin-1 promotes lymphangiogenesis and lymph node metastasis through activation of M2-type macrophages by lung cancer cells. [abstract]. In: Proceedings of the 105th Annual Meeting of the American Association for Cancer Research; 2014 Apr 5-9; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2014;74(19 Suppl):Abstract nr 3662. doi:10.1158/1538-7445.AM2014-3662
PNEUMOCOCCIC ARTHRITIS: REPORT OF A CASE TREATED WITH PENICILLIN
Authors: Henry L. Feffer, Harold L. Hirsh
Journal: Annals of Internal Medicine (1946)

Case Reports1 November 1946PNEUMOCOCCIC ARTHRITIS: REPORT OF A CASE TREATED WITH PENICILLINHENRY L. FEFFER, HAROLD L. HIRSH, M.D.HENRY L. FEFFERSearch for more papers by this author, HAROLD L. HIRSH, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-25-5-845 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptRecently Boger1 reported a case of "primary" or "cryptogenic" pneumococcic arthritis cured with sulfadiazine orally and intra-articularly. Boger reviewed the literature and collected 227 cases of pneumococcic arthritis of which 34 were considered "primary." Of these, only four cases were adequately described and can be definitely called "primary" pneumococcic arthritis. We are reporting a case of "primary" pneumococcic arthritis treated with penicillin.CASE REPORTC. D., a negro laborer, aged 29, was admitted to the Gallinger Municipal Hospital on January 5, 1944, with the complaint of pain and swelling of the left knee for five days. At that time, upon...Bibliography1. BOGER WP: Pneumococcic arthritis. Report of case of so-called primary pneumococcic arthritis, Jr. Am. Med. Assoc., 1944, cxxvi, 1062. CrossrefGoogle Scholar2. PLISSONBROUSSE : Arthrite purulente primitive à pneumocoques du genou chez l'adulte, Lyon chir., 1920, xvii, 705. Google Scholar3. CHANTEMESSEMOCAIGNECHIPAULT : Cited by Plisson and Brousse.2 Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Washington, D. C.*Received for publication March 23, 1946.From the George Washington Medical Division and the Orthopedic Service, Gallinger Municipal Hospital, and the Department of Medicine, George Washington University.†This study was done prior to Dr. Feffer's entrance into the Armed Forces. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byRHEUMATISM AND ARTHRITIS REVIEW OF AMERICAN AND ENGLISH LITERATURE OF RECENT YEARS (TENTH RHEUMATISM REVIEW)* Part IIWILLIAM D. ROBINSON, M.D., F.A.C.P., EDWARD W. BOLAND, M.D., F.A.C.P., JOSEPH J. BUNIM, M.D., F.A.C.P., DARRELL C. CRAIN, M.D., F.A.C.P., EPHRAIM P. ENGLEMAN, M.D., F.A.C.P., WALLACE GRAHAM, M.D., F.R.C.P. (C), L. MAXWELL LOCKIE, M.D., F.A.C.P., MAX M. MONTGOMERY, M.D., F.A.C.P., CHARLES RAGAN, M.D., F.A.C.P., MARIAN W. ROPES, M.D., F.A.C.P., EDWARD F. ROSENBERG, M.D., F.A.C.P., CHARLEY J. SMYTH, M.D. 1 November 1946Volume 25, Issue 5Page: 845-846KeywordsArmed forcesArthritisHospital medicineInflammationKneesOrthopedicsPenicillin ePublished: 1 December 2008 Issue Published: 1 November 1946 PDF downloadLoading ...
Effects of preoperative inspiratory muscle training (IMT) in obese women undergoing open bariatric surgery: Respiratory muscle strength
Authors: Marcela Barbalho-Moulim, Dirceu Costa, Gustavo Miguel, Flavio Campos, Eli Maria Forti
Journal: European Respiratory Journal (2011)

Introduction: Patients undergoing open bariatric surgery have an impaired lung function in the postoperative period. Aiming to attenuate these negative effects, the preoperative IMT may be an alternative.  Objective: To determine whether preoperative IMT is able to attenuate the impact of surgical trauma on the respiratory muscle strength in obese women undergoing open bariatric surgery.  Methods: This study is a randomized controlled trial. Thirty-two obese women (35.44±8.75 years and 41.78±3.84 kg/m2), undergoing elective open bariatric surgery were randomly assigned to receive preoperative inspiratory muscle training (IMT group) (n=15) or usual care (UC group) (n=17) 2-4 weeks before the surgery. The respiratory muscle strength was carried out by using measurement the Maximal Inspiratory and Expiratory Pressures – MIP and MEP. The patients were assessed before training, before surgery and 1 day after surgery.  Results: After training, there was an increase in the MIP only in the IMT group (IMT= 93.33±23.80 to 120±20.35 vs UC= 92.94±18.63 to 91.76±20.38 cmH2O - p  Conclusion: The preoperative IMT increased the inspiratory muscle strength (MIP) and attenuated the negative postoperative effects of open bariatric surgery in obese women for this variable, though not influencing the MEP.
Testosterone: A Novel Therapeutic Approach in Chronic Heart Failure?⁎⁎Editorials published in the Journal of the American College of Cardiologyreflect the views of the authors and do not necessarily represent the views of JACCor the American College of Cardiology.
Authors: Pål Aukrust, Thor Ueland, Lars Gullestad, Arne Yndestad
Journal: Journal of the American College of Cardiology (2009)
Postoperative Radiation for Women with Cancer of the Breast and Positive Axillary Lymph Nodes
Authors: Mortimer B. Lipsett
Journal: New England Journal of Medicine (1981)

IT is unfortunate that arguments about the continuing use of postoperative radiation therapy in women with breast cancer and positive findings in the axillary nodes have not been widely discussed in this country. The controversy has generally been confined to specialty journals. A report of a recent National Cancer Institute consensus-development conference on the treatment of primary breast cancer delicately avoided the issue, and a recent review1 of the state of knowledge of cancer of the breast presented many pertinent data but yielded no conclusions about the value of postoperative radiation. However, a group of physicians at the National Cancer . . .
The Adoration of the Magi
Authors: M. Therese Southgate
Journal: JAMA (2000)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The Alimentary Canal of the Medical Student, Radiographic Studies
Authors: T. Wingate Todd
Journal: Annals of Internal Medicine (1927)

Article1 December 1927The Alimentary Canal of the Medical Student, Radiographic StudiesT. WINGATE TODDT. WINGATE TODDSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-1-6-420 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe emotions which express themselves through the alimentary tract have not yet been thoroughly studied. Some slight attention was given them during the later part of the Great War when we discovered many men who had literally no stomach for fighting. Further, insufficient attention has been paid to the mechanism and appearances of the normal tract, and we need to revise the technique of our routine examinations. There is nowadays, for example, no lack of power in our X-ray apparatus causing us to demand a starved stomach and purged bowel to enable us to see through a patient.The willing... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Cleveland, Ohio*Abstract of address presented to the College of Physicians, Cleveland, Ohio, February, 1927. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 December 1927Volume 1, Issue 6Page: 420-421KeywordsEmotionsStomach ePublished: 1 December 2008 Issue Published: 1 December 1927 PDF downloadLoading ...
Long persistent bcr-abl positive transcript detected by polymerase chain reaction after marrow transplant for chronic myelogenous leukemia without clinical relapse: a study of 64 patients
Authors: K Miyamura, T Tahara, M Tanimoto, Y Morishita, K Kawashima, Y Morishima, H Saito, S Tsuzuki, K Takeyama, Y Kodera
Journal: Blood (1993)
Global Issues on the Agenda at the World Health Assembly
Authors: H D Banta
Journal: JAMA (2001)

During the World Health Assembly in May 2001 some of the high-priority issues are discussed including HIV/AIDS the WHO policy on medicines leprosy and recommendations for infant and young child feeding.  In particular the worldwide HIV/AIDS pandemic and the Global Fund to fight specific diseases in developing countries were subjects of particular interest.  In terms of policy on drugs the main point under discussion was to ensure that public health issues are taken into account as countries develop patent legislation.  The secondary issue was the revised drug strategy.  A special briefing was also conducted pointing to great progress in controlling leprosy.  Moreover the main issue in infant and young feeding tackled during the meeting is the promotion and support of breast-feeding.
After reading Su Shih’s elegy for his friend
Authors: Charles M. Israel
Journal: JAMA (2005)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Reprogramming Epigenetic Changes Blunts p66Shc-induced Vascular Dysfunction In Experimental and Human Obesity: Insights for Mechanisms-Based Therapeutic Strategies
Authors: F Paneni, S Costantino, G Capretti, A Virdis, S Chiandotto, Bianca Rocca, T Luescher, S Taddei, M Volpe, F. Cosentino
Journal: Circulation (2013)

Introduction: Epigenetic signatures may represent key modulators of oxidative stress in patients with obesity. The mitochondrial adaptor p66Shc is a major source of reactive oxygen species (ROS) in...
THE CLINICAL INTERPRETATION OF INSULIN INDUCED KETONURIA
Authors: Norman W. Drey
Journal: Annals of Internal Medicine (1945)

Article1 June 1945THE CLINICAL INTERPRETATION OF INSULIN INDUCED KETONURIANORMAN W. DREYNORMAN W. DREYSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-22-6-811 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTransient ketonuria in association with aglycosuria observed in insulin treated diabetics presents an apparent paradox. Such an observation was not uncommon at the time protamine zinc insulin was becoming popular. As pointed out by Mirsky1 the older theories concerning ketogenesis are still invoked whenever a clinical problem involving ketonuria is found. The standard texts on diabetes mellitus dwell lightly upon the newer concepts concerning ketogenesis. The significance of insulin induced ketonuria, therefore, is frequently misunderstood and the condition is treated by additional insulin.In 1935 Somogyi2observed the "causal connection between hypoglycemia and ketosis." Since this time he has expanded...Bibliography1. MIRSKY IA: The etiology of diabetic acidosis, Jr. Am. Med. Assoc., 1942, cxviii, 690. CrossrefGoogle Scholar2. SOMOGYI M: Effects of insulin upon the production of ketone bodies, Jr. Biol. Chem., 1941, cxli, 219. CrossrefGoogle Scholar3. SOMOGYIWEICHSELBAUM MTE: Ketone sparing effect of insulin, Jr. Biol. Chem., 1942, cxlv, 567. CrossrefGoogle Scholar4. SOMOGYI M: Effects of glucose feedings upon the ketonemia in healthy man, Jr. Biol. Chem., 1942, cxlv, 575. CrossrefGoogle Scholar5. SOMOGYI M: A rapid method for the estimation of urine sugar, Jr. Lab. and Clin. Med., 1941, xxvi, 1220. Google Scholar6. COLLIP JG: Proc. Am. Soc. Biol. Chem., Jr. Biol. Chem., 1923, lv, 38, quoted by Somogyi.2 Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: M.C. A.U.S. Brigham City, Utah*Received for publication October 7, 1944. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byExperimental Alteration of the Sugar and Ketone Levels of the Blood of Ruminants in Relation to Ketosis 1 June 1945Volume 22, Issue 6Page: 811-818KeywordsDiabetes mellitusGratitudeHypoglycemiaInsulinMedical servicesProtaminesZinc ePublished: 1 December 2008 Issue Published: 1 June 1945 PDF downloadLoading ...
Optical Molecular Imaging for in vivo Detection of Dysplasia
Authors: Rebecca Richards-Kortum
Journal: Clinical Cancer Research (2006)

PL-21   Cancer is a major public health problem. Currently, the clinical classification of cancer and its precursors is based on phenotypic markers, such as nuclear to cytoplasmic ratio and extent of invasion, which are then used to select therapy. In the last decade, enormous progress has been made to understand the molecular events that accompany carcinogenesis. There is an important need to image the molecular features of cancer  in vivo . Progress toward a molecular characterization of cancer would have important clinical benefits, including (1) detecting cancer earlier based on molecular characterization, (2) predicting the risk of precancerous lesion progression, (3) detecting margins in the operating room in real time, (4) selecting molecular therapy rationally and (5) monitoring response to therapy in real time at a molecular level. Our group is working to develop optically active contrast agents that can be applied topically to areas of tissue at risk to monitor the three-dimensional profile of the targeted biomarkers as well as morphologic and architectural biomarkers such as nuclear to cytoplasmic ratio. At the same time, we are developing MEMS-based inexpensive, portable optical systems to image the morphologic and molecular signatures of neoplasia noninvasively in real time. These real-time, portable, inexpensive systems can provide tools to characterize the molecular features of cancer  in vivo . We believe these contrast agents and imaging systems will have broad applicability to detect and monitor many types of cancer.
The Iowa 500: affective disorder in relatives of manic and depressed patients
Authors: G Winokur, M T Tsuang, R R Crowe
Journal: American Journal of Psychiatry (1982)

About 10% of hospitalized unipolar depressed patients ultimately became bipolar. Using a blind protocol to assess data from patient (N = 485) and first-degree relative (N = 2,803) interviews and hospital records, the authors found that bipolar probands and unipolar probands had more affective illness in their families than did control subjects. Although more relatives of bipolar probands than of unipolar probands had bipolar illness, the difference in risk for affective illness between relatives of bipolar probands and of unipolar probands was not significant. In general there were more female than male depressed relatives, bit the equal numbers of men and women among bipolar relatives suggest heterogeneity of illness within the families of bipolar probands.
Abstract 16389: Beyond Depression: Benefits of Cognitive Behavioral Therapy in Cardiac Surgery Patients
Authors: Lynn Doering, Belinda Chen, Jo-Ann Eastwood, Anthony McGuire, Rebecca Cross-Bodán, Michael Irwin
Journal: Circulation (2014)

Introduction:  Depression after cardiac surgery (CS) is associated with increased pain and decreased sleep quality. We have shown that nurse-delivered cognitive behavioral therapy (CBT) for depression is effective, but the effect of depression-focused CBT on other post-CS outcomes is unknown. The purpose of this study was to determine if CBT for depression influenced postoperative pain, sleep, perceived control, and social support.   Methods:  After screening positive for clinical depression, 53 post-CS patients (mean age = 64 ± 10 years, 83% male, 28% single) were randomized to usual care (UC) or 8 weeks of CBT by trained nurses. At baseline and post-intervention, patients completed questionnaires for depressive symptoms (Beck Depression Inventory), pain (Brief Pain Inventory), sleep (Pittsburgh Sleep Quality Index), perceived control (Cardiac Attitude Scale-Revised) and social support (Perceived Social Support Scale). Change over time was evaluated by repeated ANOVA controlling for baseline values. Patient characteristics likely to influence CBT outcomes were evaluated by linear regression.   Results:  Compared to UC, the CBT group showed greater increase in perceived control and reduction in pain interference (Figure), with a trend toward improvement in social support (time x group interaction , p = .11). Improved perceived control was significantly associated with younger age (Std Beta [SB] = -.28, p = .04) and improved sleep quality (SB = -.52, p    Conclusions:  This study demonstrates that a depression-focused CBT intervention yields benefits in other common postoperative problems. Future studies should investigate the potential of CBT as a broad therapeutic tool in this high risk population.