THE PERIPHERAL VASCULAR LESIONS OF LUPUS ERYTHEMATOSUS
Authors: E W LOWMAN, C H SLOCUMB
Journal: Annals of Internal Medicine (1952)

Article1 May 1952THE PERIPHERAL VASCULAR LESIONS OF LUPUS ERYTHEMATOSUSEDWARD W. LOWMAN, M.D., CHARLES H. SLOCUMB, M.D.EDWARD W. LOWMAN, M.D.Search for more papers by this author, CHARLES H. SLOCUMB, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-36-5-1206 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptSince the initial report in 1935 by Baehr and associates1of the diffuse peripheral vascular involvement in lupus erythematosus, much histologic investigation has been directed toward clarifying the nature and extent of this process. Initially it was the impression of these investigators that it was primarily a process of endothelial proliferation associated with narrowing and occlusion of small vessels. Subsequently, in 1941, Klemperer and his group of workers2clarified this misconception, and introduced the concept of fibrinous degeneration. It was proposed that in lupus erythematosus, collagen diffusely underwent a degenerative change as a result of an "X" stimulus, and, because...Bibliography1. BaehrKlempererSchifrin GPA: A diffuse disease of the peripheral circulation usually associated with lupus erythematosus and endocarditis, Tr. A. Am. Physicians 50: 139-155, 1935. Google Scholar2. KlempererPollackBaehr PADG: Pathology of disseminated lupus erythematosus, Arch. Path. 32: 569-631 (Oct.) 1941. Google Scholar3. Slocumb CH: Arthralgia and arthritis of lupus erythematosus, Proc. Staff Meet., Mayo Clin. 15: 683-686 (Oct. 23) 1940. Google Scholar4. MontgomeryMcCreight HWG: Disseminate lupus erythematosus, Arch. Dermat. and Syph. 60: 356-372 (Sept.) 1949. CrossrefGoogle Scholar5. FriedbergGrossWallach CKLK: Nonbacterial thrombotic endocarditis associated with prolonged fever, arthritis, inflammation of serous membranes and widespread vascular lesions, Arch. Int. Med. 58: 662-684 (Oct.) 1936. CrossrefGoogle Scholar6. Case Records of the Massachusetts General Hospital: Case 27301, New England J. Med. 225: 151-155 (July 24) 1941. CrossrefGoogle Scholar7. GinzlerFox AMTT: Disseminated lupus erythematosus: a cutaneous manifestation of a systemic disease (Libman-Sacks); report of a case, Arch. Int. Med. 65: 26-50 (Jan.) 1940. CrossrefGoogle Scholar8. CluxtonKrause HELA: Acute lupus erythematosus disseminatus, Ann. Int. Med. 19: 843-872 (Dec.) 1943. LinkGoogle Scholar9. ClawsonNobleLufkin BJJFNH: Nodular inflammatory and degenerative lesions of muscles from four hundred and fifty autopsies, Arch. Path. 43: 579-589 (June) 1947. Google Scholar10. BunimSokoloffBienWilensZiffMcEwen JJLEJSLMC: Histologic and chemical changes in skeletal muscle of patients with rheumatic and nonrheumatic disease (Abstr.), Official Program of Seventh International Congress on Rheumatic Diseases, 1949. Google Scholar11. Correa DG: Pathology of disseminated lupus erythematosus with special reference to vascular changes. Thesis, University of Minnesota Graduate School, 1946. Google Scholar12. SilvermanPowell JJVE: Peripheral vascular changes in dermatomyositis, Am. Heart J. 30: 441-446 (Nov.) 1945. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Rochester, Minnesota*Received for publication May 2, 1951.Abridgement of thesis submitted by Dr. Lowman to the Faculty of the Graduate School of the University of Minnesota in partial fulfillment of the requirements for the degree of Master of Science in Medicine.†Microscopic studies of tissue were done in the laboratory of Dr. James W. Kernohan and under his supervision.‡Fellow in Medicine, Mayo Foundation. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited bySystemic lupus erythematosus presenting as chronic serositis with no demonstrable antinuclear antibodiesATYPICAL COLLAGEN DISEASE: Polymyositis, Prominent Hematoxylin Body Formation and Some Manifestations of Progressive Systemic SclerosisAvascular necrosis of bone in systemic lupus erythematosusPeripheral Vascular Syndromes Associated with Systemic Lupus ErythematosusDONATO ALARCÓN-SEGOVIA, M.D., PHILIP J. OSMUNDSON, M.D., F.A.C.P.Lupus erythematosus and avascular bone necrosis: A clinical study of three cases and review of the literatureKrankheiten der GefäßeRHEUMATISM AND ARTHRITIS REVIEW OF AMERICAN AND ENGLISH LITERATURE OF RECENT YEARS (ELEVENTH RHEUMATISM REVIEW)* Part IIWILLIAM D. ROBINSON, M.D., F.A.C.P., JOSEPH J. BUNIM, M.D., F.A.C.P., WILLIAM S. CLARK, M.D., DARRELL C. CRAIN, M.D., F.A.C.P., EPHRAIM P. ENGLEMAN, M.D., F.A.C.P., DONALD C. GRAHAM, M.D., F.R.C.P. (C), MAX M. MONTGOMERY, M.D., F.A.C.P., BERNARD M. NORCROSS, M.D., F.A.C.P., CHARLES RAGAN, M.D., F.A.C.P., MARIAN W. ROPES, M.D., F.A.C.P., EDWARD F. ROSENBERG, M.D., F.A.C.P., CHARLEY J. SMYTH, M.D., F.A.C.P.Der viscerale Lupus erythematosus (Kaposi-Libman-Sacks-Syndrom)Collagen DiseasesTHE EFFECT OF THE L. E. CELL TEST ON THE CLINICAL PICTURE OF SYSTEMIC LUPUS ERYTHEMATOSUS*EDMUND L. DUBOIS, M.D. 1 May 1952Volume 36, Issue 5Page: 1206-1216KeywordsGraduate medical educationLesionsLupus erythematosusResearch laboratories ePublished: 1 December 2008 Issue Published: 1 May 1952 PDF downloadLoading ...