tbuckley/cabot-search huggingface dataset:
Case of Gunshot Wound of Abdomen
Authors: R. K. A. van Someren, J. D. Laycock
Journal: BMJ (1945)

MBRTICAJOURN5Lequal parts of sulphathiazole and boric acid powder.Hollender (1943) recommends sulphanilamide, provided it be mixed with boric acid powder, for if used alone it forms an obstructing cork.The choice between sulphanilamide and sulphathiazole depends on the bacteriological nature of the dischargesulphathiazole being used in the presence of a staphylococcic or pneumococcic infection, and sulphanilamide in the presence of a streptococcic infection.The first and second treatments described have allowed many recruits to pass into the Forces.
Peritoneoscintigraphy Using Tc-99m MAA for Diagnosis of Diaphragmatic Disruptions in Trauma Patients
Authors: FERNANDO CESANI, JEFFERY A. ZUCKERMANN, VIJAY B. PATANGE, ELMA G. BRISCOE
Journal: Clinical Nuclear Medicine (1996)

The diagnosis of diaphragmatic disruptions secondary to blunt trauma is difficult because the patients are usually asymptomatic. Delay in recognition of this injury can be life threatening. The presence of previous pulmonary pathology makes the diagnosis even more difficult to establish. In this report, a diaphragmatic tear was diagnosed using intraperitoneal instillation of Tc-99m MAA.
Should Specialist Endoscopists Perform All Complicated Endoscopies?
Authors: D. W. Lee, C. M. Poon, K. H. Chan, A. C. Chan
Journal: Endoscopy (2002)

Dear Sir,We have read with great interest the paper by Dafnis et al. [1] regarding the impact of endoscopist experience and learning curves on colonoscopy completion rates. The authors analyzed the completion and complication rates of 5494 colonoscopies in a Swedish county with a population of 258 000 over a period of 17 years. Although the overall completion rate was 75 %, the authors confirmed the importance of experience and intensity of workload in achieving a better completion rate.
Sequential Methods Applied to the Study of Prochlorperazine
Authors: P. Sainsbury, C. J. Lucas
Journal: BMJ (1959)

It is suggested that atherosclerosis may be the primary cause of change in the subclavian artery previously ascribed to external pressure.The importance of aortography to demonstrate the branches of the aortic arch in the thoracic outlet syndrome is emphasized.I am particularly indebted to Dr.
Case 33-1962
Authors: William V. McDermott, Austin L. Vickery
Journal: New England Journal of Medicine (1962)

Presentation of CaseA sixty-eight-year-old woman was referred to the hospital because of abdominal discomfort and splenomegaly.Two months before entry the patient passed a black stool on each of two successive days, but was asymptomatic. One month later she began to experience increasing discomfort in the left side of the abdomen, with intermittent distention, flatulence and eructation. No diarrhea or constipation occurred. She entered another hospital, where anemia, hepatosplenomegaly, guaiac-positive stools and diverticulosis of the sigmoid colon were recorded; an upper gastrointestinal series was normal.While recovering from an episode of "grippe" nineteen years previously the patient noticed a . . .
The rise of food poverty in the UK
Authors: D. Taylor-Robinson, E. Rougeaux, D. Harrison, M. Whitehead, B. Barr, A. Pearce
Journal: BMJ (2013)

Garcia Rada highlights the rise in child poverty and child malnutrition in Catalonia, Spain, since the economic crisis.1 But closer to home, the number of malnutrition related admissions to hospital in England has doubled since 2008-09 (figure⇓).2 



Admissions related to malnutrition and number of people using food banks …
Molecular characteristics of pediatric patients with sickle cell anemia and stroke
Authors: Sharada A. Sarnaik, Samir K. Ballas
Journal: American Journal of Hematology (2001)

Abstract Cerebrovascular accidents (CVA) are serious complications of sickle cell anemia (SS) in children. Factors that predispose children to this complication are not well established. In an effort to elucidate the risk factors associated with CVA in SS, we have determined the α‐globin genotype and the β S haplotype of children with this complication. Among 700 children with SS followed at Children's Hospital of Michigan, 41 (6%) are on chronic transfusions because of stroke due to cerebral infarction. The mean age of patients with CVA at the time of stroke was 5.6 ± 3.2 years (mean ± SD). The male/female ratio was 2/3. Only 8 of 41 patients (19.5%) had one α‐gene deletion, compared to the reported prevalence of 30% in African‐Americans. None of the patients had two α‐gene deletions, and two (5%) had five α‐genes. These findings are different than those in our adult patients with SS, where the prevalence of −α/−α and ααα/αα is 4% and &lt;2%, respectively. Ten different β S ‐haplotypes were detected in the patients studied. The majority of the patients (31%) were doubly heterozygous for the Ben/CAR haplotypes followed by Ben/Ben, Ben/Sen, and CAR/CAR haplotypes, respectively. The prevalence of these haplotypes, with the exception of the CAR/CAR haplotype, was higher in females than males. All the patients with CAR/CAR haplotype were males, had four α‐genes, and ranked third in prevalence. Three patients were heterozygous for the Cameron haplotype. The Cameron and atypical haplotypes were more prevalent than reported in patients with SS at large. The data suggest that CVA in children seems to occur more frequently in females and in patients with certain β S haplotype. α‐Gene deletion seems to offer a protective effect against this complication. Neonates with four or more α‐genes whose β S haplotype is Ben/CAR, atypical, or CAR/CAR seem to be at a higher risk for CAV than other patients. A prospective study on a larger group of patients with or without CVA may clarify this issue. Am. J. Hematol. 67:179–182, 2001. © 2001 Wiley‐Liss, Inc.
Principles and Practice of Radiation Oncology
Authors: Walter C. Gunn
Journal: JAMA (1992)

Ionizing radiations have been used to treat cancer patients for almost a century now. At first they were used by all types of physicians and physicists and various practitioners, and results were reported in anecdotal fashion. In the early years of this century, information was accumulated slowly and painfully, as experience taught us what patients could and could not tolerate. The concept of protracted fractionation, which now is universally recognized as the chief scientific basis of this clinical specialty, was introduced by Coutard in France in the 1920s. Regaud, in Paris, had documented that an intense single dose of radiation delivered to the scrotum of the ram was insufficient to necrotize the skin of that sensitive organ but was sufficient to sterilize the animal, while a much smaller daily dose, delivered in a series of daily fractions, not only led to complete sterility but had no permanent effect on the
Prevention of nosocomial pneumonia in intubated patients: Respective role of mechanical subglottic secretions drainage and stress ulcer prophylaxis
Authors: Ph. Mahul, C. Auboyer, R. Jospe, A. Ros, C. Guerin, Z. El Khouri, M. Galliez, A. Dumont, O. Gaudin
Journal: Intensive Care Medicine (1992)
Expression of CD14 and Toll-like receptor 2 in farmers' and nonfarmers' children
Authors: Roger P Lauener, Thomas Birchler, Jill Adamski, Charlotte Braun-Fahrländer, Albrecht Bufe, Udo Herz, Erika von Mutius, Dennis Nowak, Josef Riedler, Marco Waser, Felix H Sennhauser
Journal: The Lancet (2002)
Subcorneal colocalization of the small heat shock protein, hsp27, with keratins and proteins of the cornified cell envelope
Authors: C. Jonak, G. Klosner, C. Kokesch, D. FOdinger, H. HOnigsmann, F. Trautinger
Journal: British Journal of Dermatology (2002)

Background hsp27 is a member of the small heat shock protein family. Its expression in epidermal keratinocytes in situ and in tissue culture correlates with differentiation. Experimental evidence points to the fact that hsp27 is a molecular chaperone and is involved in the regulation of cell growth and differentiation. Objectives To investigate whether epidermal hsp27 through its chaperone function plays a role in the assembly of keratin filaments and the cornified cell envelope. Methods We performed double staining immunofluorescence and immunogold microscopy on normal human skin (n = 15). We analysed the colocalization of hsp27 with actin, keratins and proteins of the cornified cell envelope (loricrin, filaggrin, transglutaminase 1). Results Actin staining did not reveal detectable colocalization with hsp27. For keratins, transglutaminase, loricrin and filaggrin colocalization was found in more than 60% of the samples. Colocalization was confined to a narrow subcorneal layer with varying patterns of expression. Electron microscopy revealed that loricrin and filaggrin colocalize with hsp27 indirectly through binding to intermediate filaments. Conclusions These results provide morphological evidence that in normal human skin hsp27 might act as a chaperone of cornification. Investigations of the molecular hsp27 interactions with the proteins of the cornified cell envelope are necessary to gain further insight into terminal keratinocyte differentiation and disorders of keratinization.
Antistenosis Approaches Revisited, or Rating the Artery Openers Anew
Authors: Marsha F. Goldsmith
Journal: JAMA (1991)

CLEARING OUT the recurrent underbrush of fatty debris in the arterial jungle is the goal of cardiologic explorers today. Despite the nearly routine restoration of blood flow through once-clogged coronary vessels that "balloon angioplasty" makes possible, restenosis continues to be a problem. Following attack by blasting, cutting, scraping, melting, and other efforts, the plaque comes back. At the 64th annual Scientific Sessions of the American Heart Association (AHA), held in Anaheim, Calif, many presentations dealt with the safety and efficacy of alternative devices designed during the past few years to remove fatty deposits or prop open arterial walls after percutaneous transluminal coronary angioplasty (PTCA). Sometimes the new methods are tried first. In either case, success has not been great. <h3>Experimental Now, Clinical in '92?</h3> The major devices include specialized balloon and laser catheters, mechanical atherectomy or ablation devices, and metallic and bioabsorbable stents. With one exception (the Atherocath, which has
Panel Clarifies NSAID Benefits and Risks
Authors: Mike Mitka
Journal: JAMA (2006)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Comparison of Polarized and Depolarized Arrest in the Isolated Rat Heart for Long-term Preservation
Authors: A. K. Snabaitis, M. J. Shattock, D. J. Chambers
Journal: Circulation (1997)

Background Hypothermic hyperkalemic cardioplegic solutions are currently used for donor heart preservation. Hyperkalemia-induced depolarization of the resting membrane potential (E m ) may predispose the heart to Na + and Ca 2+ loading via voltage-dependent “window currents,” thereby exacerbating injury and limiting the safe storage duration. Alternatively, maintaining the resting E m with a polarizing solution may reduce ionic movements and improve postischemic recovery; we investigated this concept with the reversible sodium channel blocker tetrodotoxin (TTX) to determine (1) whether polarized arrest was more efficacious than depolarized arrest during hypothermic long-term myocardial preservation and (2) whether TTX induces and maintains polarized arrest. Methods and Results The isolated crystalloid-perfused working rat heart preparation was used in this study. Preliminary studies determined an optimal TTX concentration of 22 μmol/L and an optimal storage temperature of 7.5°C. To compare depolarized and polarized arrest, hearts were arrested with either Krebs-Henseleit (KH) buffer (control), KH buffer containing 16 mmol/L K + , or KH buffer containing 22 μmol/L TTX and then stored at 7.5°C for 5 hours. Postischemic recovery of aortic flow was 13±4%, 38±2%, and 48±3%* (* P &lt;.05 versus control and 16 mmol/L K + ), respectively. When conventional 3 mol/L KCl-filled intracellular microelectrodes were used, E m gradually depolarized during control unprotected ischemia to ≈−55 mV before reperfusion, whereas arrest with 16 mmol/L K + caused rapid depolarization to ≈−50 mV, where it remained throughout the 5-hour storage period. In contrast, in 22 μmol/L TTX-arrested hearts, E m remained more polarized, at ≈−70 mV, for the entire ischemic period. Conclusions Blockade of cardiac sodium channels by TTX during ischemia maintained polarized arrest, which was more protective than depolarized arrest, possibly because of reduced ionic imbalance.
Relationship between the MIC of vancomycin and clinical outcome in patients with MRSA nosocomial pneumonia
Authors: Eun Young Choi, Jin Won Huh, Chae-Man Lim, Younsuck Koh, Sung-Han Kim, Sang-Ho Choi, Yang Soo Kim, Mi-Na Kim, Sang-Bum Hong
Journal: Intensive Care Medicine (2011)
Narcotic Drug Addiction as Regulated by a State Department of Health
Authors: Thomas S. Blair
Journal: JAMA (2019)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Antihypertensive Action of Diazoxide
Authors: D. E. Hutcheon, K. S. Barthalmus
Journal: BMJ (1962)

In a study of its cardiovascular actions, Rubin et al (1961) reported that diazoxide produced a fall in blood pressure in renal hypertensive dogs and metacorticoid hypertensive rats without increasing sodium excretion. On isolated aortic strip preparations, this new benzothiadiazine was shown to inhibit contractions induced by noradrenaline, 5-hydroxytryptamine, and angiotensin. Previous studies have indicated that the blood-pressure of hypertensive patients treated with chlorothiazide may fall in the absence of a natriuretic response (Hollander et al, 1959). The present study was therefore designed to examine the effects of diazoxide on the blood-pressure and renal electrolyte excretion patterns of hypertensive patients to determine whether the antihypertensive and diuretic properties of the benzothiadiazines could be separated. Changes in water and electrolyte metabolism in relation to blood-pressure responses were studied. Two of the cases were also treated with trichlor methiazide to observe the effects of combining diazoxide with a thiazide diuretic.
Do Breast Implants Cause Systemic Disease? -- Science in the Courtroom
Authors: Marcia Angell
Journal: New England Journal of Medicine (1994)

In this issue of the Journal, Gabriel and colleagues report that they were unable to find an increased risk of certain disorders -- principally connective-tissue diseases -- in women who had breast implants1. Until now there has been almost no reliable evidence bearing on the subject2. Yet, despite the paucity of evidence, much of the public believes that breast implants cause connective-tissue diseases, and judges and juries have awarded large settlements to women in this belief. Why has the hypothesis that breast implants cause these diseases been so readily accepted with so little evidence to support it? And . . .
561 Safety and pharmacokinetics of the now nucleoside polymerase inhibitor, HCV-796: Results of a randomized, double-blind, placebo-controlled, ascending single-dose study in healthy subjects
Authors: P. Chandra, D. Raible, L. Moyer, D. Harper, J. Speth, S. Villano, R. Fruncillo
Journal: Journal of Hepatology (2006)
Cholesterol crystal embolisation to the alimentary tract.
Authors: W Moolenaar, C B Lamers
Journal: Gut (1996)

The features of cholesterol crystal embolisation (CCE) to the alimentary tract were studied by retrospective analysis of the clinical and pathological data of 96 patients (70 men, 26 women, mean age 73.8 (58-95) years) with this diagnosis in the Dutch national pathology information system (Pathologisch Anatomisch Landelijk Geautomatiseerd Archief (PALGA)) from 1973-92. In the 96 patients, 130 CCE sites were found throughout the alimentary tract, mostly in the colon (42.3%). Most patients had a history of atherosclerotic disease and presented with abdominal pain, diarrhoea, or gastrointestinal bleeding, sometimes after surgical or radiological vascular procedures. A number were taking oral anticoagulant treatment. The diagnosis of CCE had been considered before the histological diagnosis in only 11 patients. In the remaining cases, ischaemic colitis, tumour, and inflammatory bowel disease were suggested in the differential diagnosis. A premortem diagnosis of CCE was made in 70.8% of the cases. In 24 of the 35 necropsy examinations, CCE seemed to be directly or indirectly related to the cause of death. It is concluded that in this unselected, homogenous group of patients, CCE sites were most frequently found in the colon. They generally presented with abdominal pain, diarrhoea, and gastrointestinal blood loss. CCE often mimicked common gastrointestinal disease, leading to incorrect diagnosis.
Marrow Transplantation for Acute Nonlymphoblastic Leukemia in First Remission
Authors: E. Donnall Thomas, C. Dean Buckner, Reginald A. Clift, Alexander Fefer, F. Leonard Johnson, Paul E. Neiman, George E. Sale, Jean E. Sanders, Jack W. Singer, Howard Shulman, Rainer Storb, Paul L. Weiden
Journal: New England Journal of Medicine (1979)

MARROW transplantation provides the opportunity for aggressive antileukemic therapy without regard to marrow toxicity.1 We have reported the application of this approach combined with intensive chemoradiotherapy in patients with several classes of leukemia; these patients had received the maximum benefit of combination chemotherapy and were considered to be in the end stages of the disease.2 Marrow donors were either identical twins or HLA-identical siblings. Six of 16 recipients of syngeneic marrow and 14 of 110 recipients of allogeneic marrow are still in remission after four to nine years.3 , 4 The allogeneic recipients included 54 patients with acute nonlymphoblastic leukemia, six of . . .
Long-term memories, features, and novelty
Authors: James K. Kroger
Journal: Behavioral and Brain Sciences (2003)

Ruchkin et al. make a strong claim about the neural substrates of active information. Some qualifications on that conclusion are: (1) Long-term memories and neural substrates activated for perception of information are not the same thing; (2) humans are capable of retaining novel information in working memory, which is not long-term memory; (3) the content of working memory, a dynamically bound representation, is a quantity above and beyond the long-term memories activated, or the activity in perceptual substrates.
Natural History of Patients Hospitalized for Management of Cirrhotic Ascites
Authors: Ramon Planas, Silvia Montoliu, Belen Ballesté, Monica Rivera, Mireia Miquel, Helena Masnou, Jose Antonio Galeras, María D. Giménez, Justiniano Santos, Isabel Cirera, Rosa María Morillas, Susanna Coll, Ricard Solà
Journal: Clinical Gastroenterology and Hepatology (2006)
Calibration of densitometers for indicator dye dilution
Authors: E. C. RUSH, J. M. NEUTZE, E. A. HARRIS
Journal: Cardiovascular Research (1977)

A systematic investigation was undertaken to determine which factors affect the calibration of a Gilford monochromatic densitometer used for recording indicator-dilution curves with indocyanine green. Calibration was not influenced by variation of withdrawal speeds from 6.4 to 20.6 cm3/min but varied with differing sampling systems. Variation in haemoglobin from 10 to 17.5 g-dl-1 or in haematocrit from 30 to 60% did not affect calibration. Calibration lines showed both curvature and hysteresis. The opitcal properties of indocyanine green were not affected by storage of diluted dye in the dark for 24 hours but were altered by the presence of contrast media used in angiography. No systematic error resulted from the substitution of stored ACD blood for patient's blood in calibration although random error was increased. Recommendations based on these findings are made for a simple calibration technique which avoids systematic error.