Metabolically Healthy Overweight and Obesity
Authors: Juhee Cho, Yoosoo Chang, Seungho Ryu
Journal: Annals of Internal Medicine (2014)

Letters1 April 2014Metabolically Healthy Overweight and ObesityJuhee Cho, PhD, Yoosoo Chang, MD, and Seungho Ryu, MD, PhDJuhee Cho, PhDFrom Sungkyunkwan University, Seoul, South Korea; and Kangbuk Samsung Hospital, Sunkgyunkwan University School of Medicine, Seoul, Korea.Search for more papers by this author, Yoosoo Chang, MDFrom Sungkyunkwan University, Seoul, South Korea; and Kangbuk Samsung Hospital, Sunkgyunkwan University School of Medicine, Seoul, Korea.Search for more papers by this author, and Seungho Ryu, MD, PhDFrom Sungkyunkwan University, Seoul, South Korea; and Kangbuk Samsung Hospital, Sunkgyunkwan University School of Medicine, Seoul, Korea.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/L14-5007-5 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITORWe were surprised that Kramer and colleagues (1) used crude, unadjusted data from individual studies for their pooled estimates. In the Discussion, the authors acknowledge this limitation and indicate that smoking and physical activity could confound the observed associations. Although we agree with this statement, the authors do not mention that age and sex are also important confounders that deeply influence BMI and the rate of mortality and cardiovascular disease.The effects of confounding by all of these factors can be substantial, and we believe that evaluation of the association between BMI and mortality or cardiovascular disease ...References1. Kramer CK, Zinman B, Retnakaran R. Are metabolically healthy overweight and obesity benign conditions?: A systematic review and meta-analysis. Ann Intern Med. 2013;159:758-69. [PMID: 24297192] LinkGoogle Scholar2. Berlin JA, Santanna J, Schmid CH, Szczech LA, Feldman HI; Anti-Lymphocyte Antibody Induction Therapy Study Group. Individual patient- versus group-level data meta-regressions for the investigation of treatment effect modifiers: ecological bias rears its ugly head. Stat Med. 2002;21:371-87. [PMID: 11813224] CrossrefMedlineGoogle Scholar Author, Article, and Disclosure InformationAffiliations: From Sungkyunkwan University, Seoul, South Korea; and Kangbuk Samsung Hospital, Sunkgyunkwan University School of Medicine, Seoul, Korea.Disclosures: None disclosed. Forms can be viewed at www.acponline.org/authors/icmje/ConflictOfInterestForms.do?msNum=L14-0022. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoAre Metabolically Healthy Overweight and Obesity Benign Conditions? Caroline K. Kramer , Bernard Zinman , and Ravi Retnakaran Metabolically Healthy Overweight and Obesity Jean-Philippe Chaput and Arya M. Sharma Metabolically Healthy Overweight and Obesity Dorit Samocha-Bonet , Antony D. Karelis , and Rémi Rabasa-Lhoret Metabolically Healthy Overweight and Obesity Nathalie Esser , André J. Scheen , and Nicolas Paquot Metabolically Healthy Overweight and Obesity Gerson T. Lesser Metabolically Healthy Overweight and Obesity Katherine M. Flegal Metabolically Healthy Overweight and Obesity Caroline K. Kramer , Bernard Zinman , and Ravi Retnakaran Metabolically Healthy Overweight and Obesity Dorit Samocha-Bonet , Antony D. Karelis , and Rémi Rabasa-Lhoret Metabolically Healthy Overweight and Obesity Nathalie Esser , André J. Scheen , and Nicolas Paquot Metabolically Healthy Overweight and Obesity Gerson T. Lesser Metabolically Healthy Overweight and Obesity Katherine M. Flegal Metabolically Healthy Overweight and Obesity Caroline K. Kramer , Bernard Zinman , and Ravi Retnakaran Metabolically Healthy Overweight and Obesity Jean-Philippe Chaput and Arya M. Sharma Metrics Cited byRisk related cardiovascular changes in metabolically healthy obese adolescents 1 April 2014Volume 160, Issue 7Page: 515KeywordsBody mass indexCardiovascular diseasesConflicts of interestExerciseObesityOverweight ePublished: 1 April 2014 Issue Published: 1 April 2014 Copyright & PermissionsCopyright © 2014 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...