HYPNOTIC EFFECTS OF AN ANTIHISTAMINE—METHAPYRILENE HYDROCHLORIDE
Authors: B STRAUS, J EISENBERG, J GENNIS
Journal: Annals of Internal Medicine (1955)

Article1 March 1955HYPNOTIC EFFECTS OF AN ANTIHISTAMINE—METHAPYRILENE HYDROCHLORIDEBERNARD STRAUS, M.D., F.A.C.P., JULIUS EISENBERG, M.D., JOSEPH GENNIS, M.D., F.A.C.P.BERNARD STRAUS, M.D., F.A.C.P., JULIUS EISENBERG, M.D., JOSEPH GENNIS, M.D., F.A.C.P.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-42-3-574 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptIt is widely recognized that one of the important side effects of the antihistamines as a class is their sedative action; it has also been considered the most characteristic.1Controlled studies of their hypnotic (sleep-inducing) effect, however, are lacking. This side effect may be either desirable or objectionable, depending on the situation in which the drug is employed. It was obvious that such a side effect might be used to good advantage as a primary action, i.e., the use of antihistamines as hypnotics. This would seem to be of some value, since the toxicity of this class of compounds is...Bibliography1. FeinbergMalkielFeinberg SMSAR: The antihistamines, 1950, Year Book Publishers, Chicago. Google Scholar2. LandisZubin CJ: The alleged sedative effect of thonzylamine hydrochloride (Neohetramine), J. Lab. and Clin. Med. 38: 873-880, 1951. MedlineGoogle Scholar3. FeinbergBernstein SMTB: Histamine antagonists. VIII. N-a-Pyridyl)-N-(-Thienal)-N',N-Dimethylethylenediamine, a new anti-histaminic compound. Experimental and clinical experiences, J. Lab. and Clin. Med. 32: 1370-1373, 1947. MedlineGoogle Scholar4. FriedlaenderFriedlaender ASS: Antihistaminic, antianaphylactic and antiallergic activity of N-(a-Pyridyl)-N-(a-Thenyl)-N',N'-Dimethylethylenediamine hydrochloride, Am. J. M. Sc. 215: 530-533, 1948. CrossrefMedlineGoogle Scholar5. KierlandPotter RRT: An evaluation of thenylene hydrochloride (N,N-Dimethyl-N'-(Alpha-Pyridyl)-N'-(Alpha-Thenyl) ethylenediamine hydrochloride), Am. J. M. Sc. 216: 20-23, 1948. CrossrefMedlineGoogle Scholar6. Beecher HK: Experimental pharmacology and measurement of the subjective response, Science 116: 157-162, 1952. CrossrefMedlineGoogle Scholar7. O'DeaLiss AEM: Suicidal poisoning by methapyrilene hydrochloride with documentation by paper chromatography, New England J. Med. 249: 566, 1953. CrossrefMedlineGoogle Scholar8. RivesWardHicks HFBBML: A fatal reaction to methapyrilene (thenylene), J. A. M. A. 140: 1022, 1949. CrossrefMedlineGoogle Scholar9. Osgood EE: Report to Council on Pharmacy and Chemistry, Hypoplastic anemias and related syndromes caused by drug idiosyncrasy, J. A. M. A. 152: 816-818, 1953. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: New York, N. Y.*Received for publication April 27, 1954.From the Medical Service, Veterans Administration Hospital, Bronx, N. Y. This study was aided by a grant from the Food and Drug Administration. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byPlacebo and the Power to HealPlacebo and the Power to HealEffects of α-fluoromethylhistidine on sleep-waking parameters in ratsHypnotic Activity of Diphenhydramine, Methapyrilene, and PlaceboAntihistaminics as Central Nervous System DepressantsPrövning av dixyrazin som hypnotikum till geriatriska patienter: En dubbel-blind "cross-over" studie med dixyrazin, nitrazepam och placeboA Comparative Study of Excedrin p.m . and PlaceboObjective and Subjective Measurement of a Hypnotic, Trichlorethyl PhosphateProblems in the measurement of sleep with particular reference to the development of a motility bedPatterns of Insomnia in Depressive Illness: A Subjective EvaluationTesting of Hypnotics Under Water LoadEtude typologique du placebo-r�acteurAn experimental study of the placebo response under three different situations of painThiophene Compounds of Biological InterestSEDATIVE AND SOMNIFACIENT EFFECTS OF METHAPYRILENE-NIACINATE: COMPARISON WITH METHAPYRILENE HYDROCHLORIDE IN 53 CASESSedatives and HypnoticsTHE EFFECTS OF MEPROBAMATE AND PENTOBARBITONE SODIUM ON SLEEP AND MOTILITY DURING SLEEP: A CONTROLLED TRIAL WITH PSYCHIATRIC PATIENTSTHE ESTIMATION OF MOTILITY DURING REST OR SLEEPResponse to Drugs and PsychiatryAcross-the-counter hypnotics: Boon, Hazard, or Fraud?A study of hypnotic drugs in patients with chronic diseasesComparative Efficacy of Hypnotics: A Self-Controlled, Self-Recorded Clinical Trial in Neurotic PatientsSECOND-AIDANTI-HISTAMINES AS HYPNOTICS 1 March 1955Volume 42, Issue 3Page: 574-582KeywordsAdverse reactionsAntihistaminesFood and Drug AdministrationMedical servicesSedativesStatistical dataToxicity ePublished: 1 December 2008 Issue Published: 1 March 1955 PDF downloadLoading ...