tbuckley/cabot-search huggingface dataset:
Masked bilateral superior oblique muscle paresis
Authors: Forrest J Ellis, Leah A Stein, David L Guyton
Journal: Ophthalmology (1998)

ObjectiveThis study aimed to determine a mechanism by which the masked bilateral superior oblique muscle paresis phenomenon may be explained.DesignA retrospective study of the authors' patients with the preoperative diagnosis of a unilateral superior oblique muscle paresis was performed. Patients in whom an apparent contralateral superior oblique muscle paresis developed after surgery (masked bilateral superior oblique muscle paresis) were compared with those patients in whom this condition did not develop.ParticipantsOne hundred eight patients participated.ResultsOf the 108 patients studied, 30 (27.7%) patients had signs of an apparent superior oblique muscle paresis develop in the contralateral eye after surgery. In comparing those patients in whom an apparent contralateral superior oblique muscle paresis did develop after surgery with those patients in whom this finding did not develop, no significant differences were found in the age at surgery; etiology (traumatic vs. nontraumatic); average hyperdeviations in primary gaze, ipsilateral and contralateral gazes, and ipsilateral and contralateral head tilts; average V pattern; inferior and superior oblique muscle function; extorsion on double Maddox rod testing; and objective fundus extorsion.ConclusionAnalysis of the authors' data showed that a surgical overcorrection of a unilateral superior oblique muscle paresis can masquerade as an apparent contralateral superior oblique muscle paresis. This is caused by a persistence of the head tilt and side gaze misalignment pattern from the original superior oblique muscle paresis.
The Relationship Between Egfr and Kras Mutation Status and Overall Survival (Os) in the Ncic Ctg Br.26 Randomized Trial of Dacomitinib (D) Versus Placebo (P) in Patients with Previously Treated Non Small Cell Lung Cancer (Nsclc)
Authors: P.M. Ellis, G. Liu, M. Millward, F. Perrone, F. Shepherd, L. Seymour, S. Sun, B. Cho, A. Morabito, M.R. Stockler, N.B. Leighl, C. Lee, R. Wierzbicki, A. Favaretto, M. Tsao, C.F. Wilson, I. Taylor, K. Ding, G. Goss, P.A. Bradbury
Journal: Annals of Oncology (2014)
Evaluation of Gianturco Coils for Closure of Large (≥3.5 mm) Patent Ductus Arteriosus 11All editorial decisions for this article, including selection of referees, were made by a Guest Editor. This policy applies to all articles with authors from the University of California San Francisco.
Authors: Carl Y. Owada, David F. Teitel, Phillip Moore
Journal: Journal of the American College of Cardiology (1997)
The lines of Blaschko: a review and reconsideration
Authors: ROBERT JACKSON
Journal: British Journal of Dermatology (1976)

Blaschko's lines are the pattern assumed by many different naevoid and acquired skin diseases on the human skin and mucosae. They were described and drawn by Blaschko 75 years ago. These lines are to be distinguished from other linear patterns such as Voight's lines, Langer's lines, and the lines of innervation of the spinal nerves. They do not follow any known nervous, vascular or l5rmphatic structures in the skin. The epidermis and its appendageal structures, the melanocytes, the vascular system, and the fatty hypoderm, all, separately or in combination, may be involved in the morpho-logical manifestations which follow Blaschko's lines. Many of the naevoid skin conditions are lifelong (e.g. linear sebaceous naevus, unilateral naevoid telangiectasia); many of the acquired skin diseases (e.g. lichen striatus, linear psoriasis) are of relatively short duration (e.g. 1–2 years). The cause of the distribution pattern is unknown. It is possibly a form of human'mosaicism' where certain specific cells or groups of cells react differently from other cells due to chromosomal abnormalities. The embryological explanation of Blaschko's lines is not at all clear. Other markers in addition to the skin findings are needed to determine the time and the nature of the change responsible for these lines. The main purpose of this article is to introduce the concept of Blaschko's lines into the medical, paramedical, and general biological fields of science. In this way, it is hoped that some inter-reaction can occur between those who regularly see Blaschko's lines and those who regularly see and study other chromosomal and embryological abnormalities.
Researchers Probe Anemia–Heart Failure Link
Authors: Mike Mitka
Journal: JAMA (2003)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Abstract 16235: The Impact of Atrial Fibrillation on Heart Failure With Preserved versus Reduced Ejection Fraction in the Middle East Region: Insights From the Gulf aCute heArt failuRe rEgistry (Gulf CARE)
Authors: Nidal A Asaad, Kadhim Sulaiman, Mohammed K Mohsen, Jassim Al-Suwaidi, Alawi Alsheikh-Ali, Dawood Darbar, Rajvir Singh, Khalid F AlHabib, Husam AlFaleh, Abdelfatah Elasfar, Ahmed Al-Motarreb, Prashanth Panduranga, Wael Almahmeed, Nooshin Bazargani, Mustafa Ridha, Bassam Bulbanat, Mohammed Al-Jarallah, Haitham Amin, Christian Bollensdorff, Amar M Salam, Magdi Yacoub
Journal: Circulation (2014)

Background: Atrial Fibrillation (AF) and heart failure (HF) are two common prevalent conditions that may present independent of each other or coexist. The impact of AF on mortality in patients with HF and reduced (HFrEF) or preserved ejection fraction (HFpEF) is unclear with conflicting results. Methods: We analyzed data from the Gulf acute HF registry, a prospective, multinational registry of patients admitted with acute HF in 47 hospitals in 7 Middle Eastern Arab Gulf countries (recruited between February 13, 2012 and November 13, 2012). We compared the 12-month mortality in patients with AF versus sinus rhythm (SR) in both types of HF (HFrEF and HFpEF). Results: Among 5005 patients admitted with HF, 835 patients (16.7%) had AF and 3964 (79.2 %) had no history of AF and were in SR. Remaining percentage included patients with rhythms other than AF or SR (e.g. junctional rhythm). After excluding patients with no available echocardiography and those with other rhythms, the number of patients in our study population was 4394 patients where 770 patients (17.5 %) were in the AF group ( 10.2% with HFrEF and 7.3% with HFpEF) and 3624 patients (82.5 %) were in the SR group (56.2% with HFrEF and 26.3% with HFpEF). The mortality at 12 month was significantly higher in the AF compared to SR group (21.1% vs. 16.3%; P = 0.001), even after covariate adjustment (odds ratio [OR] = 1.23, 95% C.I 1.01-1.5; P = 0.04). Furthermore, subgroup analysis revealed that AF was associated with a higher risk of 12 month mortality in patients with HFrEF (23.7% vs. 16.6%; P = 0.001) but not among patients with HFpEF (17.5% vs. 15.8%; P = 0.48), even after covariate adjustment (adjusted OR among patients with HFrEF = 1.40, 95% C.I. 1.10-1.80; P=0.009 while adjusted OR among patients with HFpEF = 0.93. 95% C.I.:0.65 - 1.32; P=0.67). Conclusion: AF is associated with significantly higher 12-month mortality among patients with HFrEF, but not among those with HFpEF, suggesting a stronger impact of AF in patients with systolic HF.
Studies on the proteins of rhabdomyosarcoma and normal muscle in mice; electrophoretic and biscometric measurements.
Authors: Miller Gl, Green Eu
Journal: Cancer Research (1950)

Summary  Exploratory electrophoretic and viscometric studies have been made of extracts of rhabdomyosarcoma and normal muscle of the mouse and of certain fractions obtained therefrom.  Electrophoretic measurements revealed seven major components in the tumor extracts and three major components in the muscle extracts. Mobility data indicated that none, except possibly one, of the major components of tumor is identical with any of those of normal muscle. Myosin preparations isolated from each type of tissue also differed in their mobilities. The possibility that some of the major components revealed by electrophoresis may represent groups of components was pointed out, and its significance was discussed.  The ribose-containing heavy material obtained from tumor tissue by centrifugation at 8,000  g  was studied electrophoretically and found to be quite homogeneous.  Viscometric studies of the myosin of tumor and of muscle revealed that the former was significantly less viscous than the latter. The ribose-containing heavy material was found to be still less viscous. These results were interpreted to indicate that molecules of tumor myosin were less asymmetric than those of normal muscle myosin, while particles of heavy material were still less asymmetric.
Polymyositis and Dermatomyositis: Combined Methotrexate and Corticosteroid Therapy
Authors: ALLAN L. METZGER
Journal: Annals of Internal Medicine (1974)

Twenty-two patients with polymyositis and dermatomyositis were treated with combined prednisone and intravenous methotrexate when moderate to high-dose cortisone alone was ineffective in controlling disease activity. Definite clinical improvement was noted in 17 or 77% of the patients. Those patients responding to therapy normalized their muscle enzymes (creatine Phosphokinase, CPK) after a mean period of 10 weeks; moreover, the onset of muscle strength improvement was noted at an average of 13 weeks. A "steroid-sparing" effect was noted in that the prednisone dose has been decreased from 47 mg/day (premethotrexate) to 12 mg/day at 15 months follow-up. Toxicity to methotrexate was minor and reversible. After an average treatment period of more than 1 year, and a total average dose of over 1 g methotrexate, clinical and laboratory hepatotoxicity was not found. Intravenous methotrexate is an important treatment for polymyositis and dermatomyositis.
Mitochondrial DNA damage as a biomarker for ultraviolet radiation exposure and oxidative stress
Authors: M.A. Birch-Machin, E.V. Russell, J.A. Latimer
Journal: British Journal of Dermatology (2013)

Journal Article Mitochondrial DNA damage as a biomarker for ultraviolet radiation exposure and oxidative stress Get access M.A. Birch‐Machin, M.A. Birch‐Machin Department of Dermatological Sciences, Institute of Cellular Medicine, Medical School, Newcastle University, Newcastle upon Tyne NE2 4HH, U.K Mark A. Birch‐Machin E‐mail: m.a.birch-machin@ncl.ac.uk Search for other works by this author on: Oxford Academic Google Scholar E.V. Russell, E.V. Russell Department of Dermatological Sciences, Institute of Cellular Medicine, Medical School, Newcastle University, Newcastle upon Tyne NE2 4HH, U.K Search for other works by this author on: Oxford Academic Google Scholar J.A. Latimer J.A. Latimer Department of Dermatological Sciences, Institute of Cellular Medicine, Medical School, Newcastle University, Newcastle upon Tyne NE2 4HH, U.K Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 169, Issue s2, 1 July 2013, Pages 9–14, https://doi.org/10.1111/bjd.12207 Published: 01 July 2013 Article history Accepted: 15 November 2012 Published: 01 July 2013
Normalization of auditory physiology by cigarette smoking in schizophrenic patients
Authors: L E Adler, L D Hoffer, A Wiser, R Freedman
Journal: American Journal of Psychiatry (1993)

Because many schizophrenic patients are heavy smokers, it has been suggested that nicotine normalizes some neuronal deficit involved in their illness. Schizophrenic subjects have various difficulties with maintenance of attention and selective processing of sensory information. One defect in sensory gating in schizophrenia has been characterized by recording auditory evoked potentials. Most normal subjects have a decrease in the evoked response to the second of two closely paired stimuli, whereas most schizophrenic subjects do not. The aim of this study was to determine whether smoking normalizes this deficit in auditory sensory gating in schizophrenia.Changes in auditory sensory gating in response to smoking cigarettes were studied in 10 smokers without psychiatric illness and 10 schizophrenic smokers. Both groups were asked to abstain from smoking from 11:00 p.m. until 8:00 a.m. the next morning, when their auditory evoked responses to pairs of clicks were recorded. The ability to gate sensory information is reflected in a decrease in the P50 wave amplitude in response to the second of the two stimuli. After baseline recordings, the subjects smoked as much as they wished, and then two postsmoking recordings were performed.The schizophrenic patients had a marked but brief improvement in P50 auditory gating immediately after smoking, whereas P50 gating for the normal smokers was slightly impaired.This study suggests that cigarette smoking can transiently normalize the impairment of auditory sensory gating in schizophrenic patients.
THE PRACTICAL USE OF HOBBIES IN THE PRACTICE OF MEDICINE
Authors: John R. Hamilton
Journal: Annals of Internal Medicine (1936)

Article1 February 1936THE PRACTICAL USE OF HOBBIES IN THE PRACTICE OF MEDICINEJOHN R. HAMILTON, M.D., F.A.C.P.JOHN R. HAMILTON, M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-9-8-1129 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptIt is my purpose in the following pages to discuss those conditions in which hobbies are a rational and necessary method of correction; and to point out that the discovery or development of hobbies for patients suffering from certain types of diseases should be more fully recognized as a definite and distinct type of treatment. Hobbies should be studied in regard to the form used, the type administered, the indications and contraindications, harmful effects, and other points of interest so that the results may be observed and controlled as in any other type of treatment.First let us establish a...References1. TAUSSIGMEYER CWTA: Book of hobbies, Minton, Balch, 1924. Google Scholar2. CALKINS EE: Care and feeding of hobby horses, Leisure League of America, 1934. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Nassawadox, Virginia*Received for publication December 26, 1934. (Presented before the Seaboard Medical Association of Virginia and North Carolina, Kinston, N. C., December 5, 1934.) PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 February 1936Volume 9, Issue 8Page: 1129-1133 Issue Published: 1 February 1936 PDF downloadLoading ...
The Osteoporotic Syndrome: Detection, Prevention, and Treatment.
Authors: Louis V. Avioli
Journal: Annals of Internal Medicine (1984)

Metabolic bone degeneration (osteoporosis) affects millions of people - primarily postmenopausal women - and is directly responsible for debilitating hip, vertebral, and limb fractures in the elderly. Incorporating advances made within just the past five years,  Osteoporotic Syndrome: Detection, Prevention, and Treatment serves as an up-to-date, practical guide to the major clinical aspects of osteoporosis. The text is liberally illustrated with detailed figures. As a resource for the clinician dealing with metabolic bone degeneration, this book represents an excellent source of information on the diagnosis and day-to-day management of osteoporosis. The topics covered include: therapy with vitamin D metabolites, sodium fluoride, thiazides, and isoflavones; biochemical markers of bone turnover; calcium, vitamin D, and bone metabolism; estrogens and tissue selective estrogens for prevention and treatment of osteoporosis; the effects of osteoporosis on orthopaedic surgery; the therapy of glucocorticoid bone disease; effects of aging on bone structure and metabolism; management of osteoporotic patients in our health care delivery system; the genetics of osteoporosis; bisphosphonate therapy for osteoporosis; calcitonin; bone mass measurement techniques in clinical practice; and, osteoporosis and the bone biopsy.
The American Text=book of Operative Dentistry.
Authors: Arthur Bertram Gabel
Journal: JAMA (1897)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
A Prospective Comparison of NMR-Measured LDL Particle Number, Apolipoprotein B100, and Standard Lipids with Incident CHD in 27,673 Initially Healthy Women
Authors: Samia Mora
Journal: Circulation (2007)

Abstract 3481 Samia Mora, Brigham And Womens Hosp, Boston, MA; James Otvos, LipoScience, Inc., Raleigh, NC; Julie E Buring, Brigham And Women’s Hospital, Boston, MA; Nader Rifai, Boston Children’s Hosp, Boston, MA; Paul M Ridker, Brigham And Women’s Hospital, Boston, MA Samia Mora, 2007 Finalist and Presenting Author
Abstract 17126: Comparison of Wave-free Ratio with Fractional Flow Reserve in Patients with Diabetes Mellitus and with Prior Myocardial Infarction
Authors: Tomoyuki Ikeda, Masafumi Ueno, Shinichirou Ikuta, Takashi Nakamura, Kazuhiro Kobuke, Yoshitaka Iwanaga, Syunichi Miyazaki
Journal: Circulation (2014)

Background: The instantaneous wave-free ratio (iFR) is adenosine-independent pressure-derived index, reported as a new method to evaluate coronary stenosis severity. Although previous studies reported the cut-off value of iFR was 0.86- 0.93, it is unclear whether or not it is applicable for the patients with diabetes mellitus (DM) and/or those with prior myocardial infraction (MI) in whom possible microvascular damage may exist. Purpose: To evaluate of usefulness of iFR, and determine optimal cut-off value of iFR in patients with DM and prior MI. Method: A total of 60 patients (80 stenosis) were assessed from November 2012 to December 2013. Of these, 25 patients (33stenosis; 41.2%) had DM and 23 (24 stenosis; 31.2%) had prior MI. Intracoronary pressure and flow velocity were measured distal to the stenosis at rest and during adenosine-mediated hyperemia. iFR was calculated and averaged using three heart beats,as a ratio of distal to proximal coronary pressures over the wave-free period in diastole. Result...
Abstract 4146: Polymorphisms of GSTT1, APE1 and MUTYh gene and the risk of oral squamous cell carcinoma
Authors: Chih-Hsiung Lai, Li-Ling Chiu, Huei-Tzu Chien, Saou-Hsing Liou, Shiang-Fu Huang, I-How Chen, Chun-Ta Liao, Ling-Ling Hsieh
Journal: Cancer Research (2014)

Abstract In Taiwan, oral cancer (including sub-sites in the oral cavity, oropharynx and hypopharynx) is the fourth most common cancer in men. According to the cancer registry report from the Ministry of Health and Welfare of the Executive Yuan, the annual age-adjusted incidence for oral cancer in males has shown a 1.55-fold increase in the past decade. Cigarette smoking, areca quid (AQ) chewing and alcohol drinking have been unveiled as the major risk factors. Previous studies have implicated that oxidative stress generated from cigarette smoking, AQ chewing and alcohol drinking contributed to oral cancer development. It is well known that GSTM1 and GSTT1 are involved in the detoxification of oxidative free radicals and nearly all oxidative DNA lesions are repaired via the DNA base excision repair (BER) pathway. To investigate the role of GSTM1, GSTT1 and BER genes (including OGG1, APE1, MUTYh, WRN and XRCC1) involved in OSCC risk in Taiwan, a comprehensive study on evaluation of polymorphisms of above genes was carried out in 1139 OSCC male cases and 1470 general males. A significant effect of AQ chewing or AQ chewing combined with cigarette smoking or alcohol drinking on the risk of OSCC was observed. GSTT1 null genotype was significantly associated with an increased risk of OSCC (odds ratio (OR), 2.10; 95% confidence interval (CI), 1.64-2.68, p = 0.000000003). After adjustment for cigarette smoking, AQ chewing and alcohol drinking, GSTT1 null-type variant was still significantly associated with an increased risk of OSCC (OR= 2.00; 95% CI, 1.42-2.81, p = 0.00007), while GSTM1 was not associated with OSCC risk. Polymorphisms of OGG1 Ser326Cys, APE1 Asp148Glu, APE1 T-656G, MUTYh Gln324His, WRN Cys1367Arg, and XRCC1 Arg399Gln were not associated with OSCC risk in general. However, stratification analysis indicated that polymorphisms of APE1 Asp148Glu and MUTYh Gln324His were associated with OSCC risk in individuals with cigarette smoking combined with AQ chewing. Furthermore, those individuals with either APE1 148 Asp/Asp or MUTYh 324 His/His genotype had an increased OSCC risks when compared to those with APE1 148 Glu and MUTYh 324 Gln allele (OR = 1.48; 95% CI, 1.13-1.95, p = 0.005). In conclusion, our results demonstrated that polymorphisms of genes involved in detoxification and BER of oxidative stress could influence the OSCC risk especially for those have history of cigarette smoking and AQ chewing. Citation Format: Chih-Hsiung Lai, Li-Ling Chiu, Huei-Tzu Chien, Saou-Hsing Liou, Shiang-Fu Huang, I-How Chen, Chun-Ta Liao, Ling-Ling Hsieh. Polymorphisms of GSTT1, APE1 and MUTYh gene and the risk of oral squamous cell carcinoma. [abstract]. In: Proceedings of the 105th Annual Meeting of the American Association for Cancer Research; 2014 Apr 5-9; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2014;74(19 Suppl):Abstract nr 4146. doi:10.1158/1538-7445.AM2014-4146
Mutations in SPINK5, encoding a serine protease inhibitor, cause Netherton syndrome
Authors: Stéphane Chavanas, Christine Bodemer, Ariane Rochat, Dominique Hamel-Teillac, Mohsin Ali, Alan D. Irvine, Jean-Louis Bonafé, John Wilkinson, Alain Taïeb, Yann Barrandon, John I. Harper, Yves de Prost, Alain Hovnanian
Journal: Nature Genetics (2000)