THE CLINICAL USE OF CRYSTALLINE INSULIN
Authors: Samuel S. Altshuler
Journal: Annals of Internal Medicine (1937)

Article1 December 1937THE CLINICAL USE OF CRYSTALLINE INSULINSAMUEL S. ALTSHULER, M.D., F.A.C.P.SAMUEL S. ALTSHULER, M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-11-6-901 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptSince the discovery of insulin by Banting and Best,1 unremitting effort has been put forth toward the improvement of the product. One of the lines of endeavor has been to make insulin purer by crystallization.Insulin was first crystallized by Abel2, 3, 4in 1926. He prepared it from highly purified commercial preparations. Howard and DeLawder5were the first to determine whether this crystalline insulin could be used therapeutically in human beings for the treatment of diabetes mellitus. Four diabetic patients were carefully regulated on diets and standard insulin; then crystalline insulin was substituted for standard in equivalent doses. They...Bibliography1. BANTINGBEST FGCH: The internal secretions of the pancreas, Jr. Lab. and Clin. Med., 1921, vii, 251-266. Google Scholar2. ABELGEILING JJEM: Researches on insulin; is insulin an unstable sulphur compound? Jr. Pharm. and Exper. Therap., 1925, xxv, 423-448. Google Scholar3. ABEL JJ: Crystalline insulin, Proc. Natl. Acad. Sci., 1926, xii, 132-136. CrossrefGoogle Scholar4. ABELGEILINGROUILLIERBELLWINTERSTEINER JJEMCAFKO: Crystalline insulin, Jr. Pharm. and Exper. Therap., 1927, xxxl, 65-85. Google Scholar5. HOWARDDELAWDER JEA: Crystalline insulin in the treatment of diabetes mellitus, Johns Hopkins Hosp. Bull., 1933, lii, 173-178. Google Scholar6. ALTSHULERLEISER SSR: Clinical experience with an improved crystalline insulin, Jr. Am. Med. Assoc., 1936, cvii, 1626-1629. CrossrefGoogle Scholar7. FREUNDADLER HAS: Effects of standard, protamine and crystalline insulin on blood sugar levels, Jr. Am. Med. Assoc., 1936, cvii, 573-577. CrossrefGoogle Scholar8. MAINSMCMULLEN MPCJ: The clinical investigation of an improved crystalline insulin, Jr. Am. Med. Assoc., 1936, cvii, 959-962. CrossrefGoogle Scholar9. BARACH J: Crystalline insulin, ANN. INT. MED., 1937, x, 1335-1344. Google Scholar10. TUFT L: Insulin hypersensitiveness; immunologic considerations and case reports, Am. Jr. Med. Sci., 1928, clxxvi, 707-720. CrossrefGoogle Scholar11. ALLANSCHERER FNLR: Insulin allergy, Proc. Staff Meetings Mayo Clinic, 1932, vii, 204-207. Google Scholar12. BURGER M: Über die physiologische und klinische Bedeutung der primaren Insulinhyperglykämie, Verhandl. d. deutsche Ges. f. inn. Med. Kong., 1929, xli, 508-509. Google Scholar13. BURGERKRAMER MH: Über den Hepatischen Angriffspunkt des Insulins, Ztschr. f. d. ges. exper. Med., 1929, lxv, 487-497. CrossrefGoogle Scholar14. BURGER M: Die physiologische Bedeutung der primaren Insulinhyperglykämie, (abstract) Am. Jr. Physiol., 1929, xc, 302-303. Google Scholar15. BURGER M: Die klinische Bedeutung der initialen Insulinhyperglykämie, Klin. Wchnschr., 1930, ix, 104-108. CrossrefGoogle Scholar16. BURGER M: Die klinische Bedeutung des hyperglykämisierenden Prinzips im Pankreas (der sogenannten initialen Insulinhyperglykämie), Klin. Wchnschr., 1931, x, 351-354. CrossrefGoogle Scholar17. BURGERKRAMER MH: Über den muskulären Angriffspunkt des Insulins, Ztschr. f. d. ges. exper. Med., 1928, lxi, 449-464. CrossrefGoogle Scholar18. BURGERKRAMER MH: Primäre Hyperglykämie und Glykogenverarmung der Leber als Folge intraportaler Insulininjektion nach Untersuchungen am Hund, Ztschr. f. d. ges. exper. Med., 1929, lxvii, 441-450. CrossrefGoogle Scholar19. BURGERKRAMER MH: Die primäre initiale Insulinhyperglykämie nach Nebennierenexstirpation, Ztschr. f. d. ges. exper. Med., lxix, 57-63. Google Scholar20. BURGERKRAMER MH: Über die durch Muskelarbeit hervorgerufene Steigerung der Insulininwirkung auf den Blutzuckergehalt beim normalen und gestörten Kohlehydratstoffwechsel und ihre praktische und theoretische Bedeutung, Klin. Wchnschr., 1928, vii, 745-750. CrossrefGoogle Scholar21. BURGERKRAMER NH: Über die Wirkungsverschiedenheit technischer Insuline und kristallisierter Präparate bezüglich der primären Insulinhyperglykämie, Arch. f. exper. Path. u. Pharm., 1930, clvi, 1-17. Google Scholar22. GEILINGDELAWDER EMA: Studies on crystalline insulin: does insulin cause initial hyperglycemia? Jr. Pharm. and Exper. Therap., 1930, xxxix, 369-385. Google Scholar23. TANGLTHAN HF: Über eine aus Pankreas gewonnene blutzuckererhöhende Substanz, Biochem. Ztschr., 1933, cclxvi, 448-451. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Eloise, Michigan*Read at the St. Louis meeting of the American College of Physicians, April 22, 1937. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byAnalysis of the Accessory Factors in the Causation of Dermal Reactions to InsulinInsulin-Allergie und Insulin-ResistenzPROCEEDINGS OF THE TWENTYFIRST SCANDINAVIAN CONGRESS FOR INTERNAL MEDICINEGeneralized allergic reactions to insulinClinical Experience With Crystalline Insulin 1 December 1937Volume 11, Issue 6Page: 901-906KeywordsDiabetes mellitusDietInsulin Issue Published: 1 December 1937 PDF downloadLoading ...