tbuckley/cabot-search huggingface dataset:
Confinement of premature impulses in functional compartments of regions of the A-V conducting system
Authors: R. J. MYERBURG, H. GELBAND, B. F. HOFFMAN
Journal: Cardiovascular Research (1973)

Journal Article Confinement of premature impulses in functional compartments of regions of the A-V conducting system Get access ROBERT J. MYERBURG, ROBERT J. MYERBURG 2 From the Department of Pharmacology, College of Physicians and Surgeons, Columbia University, New York, New York; and the Veterans Administration Hospital, and the Department of Medicine, Physiology, and Pediatrics, University of Miami School of Medicine, Miami, Florida, U.S.A. 2Present addresses: Veterans Administration Hospital and University of Miami School of Medicine, Miami, Florida, 33125; U.S.A. Search for other works by this author on: Oxford Academic PubMed Google Scholar HENRY GELBAND, HENRY GELBAND 2 From the Department of Pharmacology, College of Physicians and Surgeons, Columbia University, New York, New York; and the Veterans Administration Hospital, and the Department of Medicine, Physiology, and Pediatrics, University of Miami School of Medicine, Miami, Florida, U.S.A. 2Present addresses: Veterans Administration Hospital and University of Miami School of Medicine, Miami, Florida, 33125; U.S.A. Search for other works by this author on: Oxford Academic PubMed Google Scholar BRIAN F. HOFFMAN BRIAN F. HOFFMAN From the Department of Pharmacology, College of Physicians and Surgeons, Columbia University, New York, New York; and the Veterans Administration Hospital, and the Department of Medicine, Physiology, and Pediatrics, University of Miami School of Medicine, Miami, Florida, U.S.A. Search for other works by this author on: Oxford Academic PubMed Google Scholar Cardiovascular Research, Volume 7, Issue 1, January 1973, Pages 69–81, https://doi.org/10.1093/cvr/7.1.69 Published: 01 January 1973
Christopher Berkeley ("Kit") Wynn Parry
Authors: A. Gulland
Journal: BMJ (2015)

Rheumatologist who specialised in hand injuries and performing arts medicine



When as a young medical graduate Kit Wynn Parry found out that the Royal Air Force was looking for recruits for the new specialty of physical medicine, he jumped at the chance. As a student during the second world war he had missed out on active service and, like many of his peers, was keen to serve.

The specialty emerged during the war to enable pilots—who were expensive to train and in short supply—to quickly return to active service after injury. Physical medicine, later known as rehabilitation, was new and exciting, “a young man’s specialty,” as Wynn Parry described it.1

Wynn Parry had started to specialise in rheumatology at John Radcliffe Hospital in Oxford, where he had worked for Herbert Seddon, professor of orthopaedic surgery. Seddon had done some early work classifying nerve injuries, their treatment, and neuropathic pain.

Wynn Parry developed this interest when he joined the combined services rehabilitation units at Headley Court and Chessington in Surrey in 1948. He became an expert on treatment of hand injuries—largely self taught as there was nothing in the medical literature. He soon remedied this with his first …
Prediction of Atrial Fibrillation via Atrial Electromechanical Interval After Coronary Artery Bypass Grafting
Authors: Farideh Roshanali, Mohammad Hossein Mandegar, Mohammad Ali Yousefnia, Hussein Rayatzadeh, Farshid Alaeddini, Farshad Amouzadeh
Journal: Circulation (2007)

We assessed the validity of the atrial electromechanical interval, measured by transthoracic tissue Doppler echocardiography, in determining patients at risk of post-coronary artery bypass graft atrial fibrillation (AF).This prospective study recruited 355 patients in sinus rhythm who were candidates for coronary artery bypass grafting. The patients underwent a preoperative transthoracic echocardiography with a tissue Doppler evaluation and were monitored with continuous ECG telemetry during their hospital stay. Sixty-eight patients had postoperative AF (19.2%), with the incident occurring 2.3+/-0.7 days after surgery. The median length of hospitalization was 7.0 days for the AF patients and 6.0 days for the non-AF patients (P<0.0001). The subjects with postoperative AF differed from the sinus rhythm patients in that the former had a lower ejection fraction (40.4+/-8.5% versus 48.4+/-9.4%), a reduced maximal A-wave transmitral Doppler flow velocity (44.3+/-4.6 versus 53.3+/-10.9 cm/s), an increased total atrial volume (68.7+/-12.6 versus 55.3+/-11.8 mL), and a prolonged atrial electromechanical interval (141.9+/-13.4 versus 100.3+/-10.3 ms, respectively; P<0.0001 for all). In addition, the AF patients were older than the sinus rhythm group (66.0+/-8.0 versus 59.8+/-8.5 years). The atrial electromechanical interval was the best independent discriminator of the history of AF. We defined a cutoff point for the atrial electromechanical interval and chose 120 milliseconds for categorization, which yielded 100% sensitivity and 94.8% specificity for the prediction of AF.The atrial electromechanical interval by transthoracic tissue Doppler echocardiography could be a valuable method for identifying patients vulnerable to post-coronary artery bypass graft AF.
Under half of senior house officers in Anglia in 1997 were United Kingdom graduates
Authors: J. Biggs
Journal: BMJ (1998)

Editor—The senior house officer grade in Britain has seen the effects of the new deal on junior doctors' hours and conditions, recent rapid expansion,1 problems in recruitment, and an imbalance of people and places.2 To find out the present make up of the grade, the Anglian postgraduate dean's database of 3 July 1997 was analysed.

Of 682 trainees in post, 469 held nationality or residence status …
Bone SPECT and Three-Dimensional Surface Display with Tc-99m MDP in Ameloblastoma
Authors: JUNJI ISHIMURA, MINORU FUKUCHI
Journal: Clinical Nuclear Medicine (1990)

Bone scintigraphy with Tc-99m MDP was performed for preoperative evaluation of a patient with a ballooning deformity of the right mandible caused by a large ameloblastoma. Bone SPECT and three-dimensional surface display performed sterioscopically showed the deformity more clearly than did routine planar imaging.
Statin Exposure Is Associated with Decreased Asthma-related Emergency Department Visits and Oral Corticosteroid Use
Authors: Sze Man Tse, Lingling Li, Melissa G. Butler, Vicki Fung, Elyse O. Kharbanda, Emma K. Larkin, William M. Vollmer, Irina Miroshnik, Donna Rusinak, Scott T. Weiss, Tracy Lieu, Ann Chen Wu
Journal: American Journal of Respiratory and Critical Care Medicine (2013)

Rationale: Statins, or HMG-CoA reductase inhibitors, may aid in the treatment of asthma through their pleiotropic antiinflammatory effects.Objectives: To examine the effect of statin therapy on asthma-related exacerbations using a large population-based cohort.Methods: Statin users aged 31 years or greater with asthma were identified from the Population-Based Effectiveness in Asthma and Lung population, which includes data from five health plans. Statin exposure and asthma exacerbations were assessed over a 24-month observation period. Statin users with a statin medication possession ratio greater than or equal to 80% were matched to non–statin users by age, baseline asthma therapy, site of enrollment, season at baseline, and propensity score, which was calculated based on patient demographics and Deyo-Charlson conditions. Asthma exacerbations were defined as two or more oral corticosteroid dispensings, asthma-related emergency department visits, or asthma-related hospitalizations. The association between statin exposure and each of the three outcome measures was assessed using conditional logistic regression.Measurements and Main Results: Of the 14,566 statin users, 8,349 statin users were matched to a nonuser. After adjusting for Deyo-Charlson conditions that remained unbalanced after matching, among statin users, statin exposure was associated with decreased odds of having asthma-related emergency department visits (odds ratio [OR], 0.64; 95% confidence interval [CI], 0.53–0.77; P < 0.0001) and two or more oral corticosteroid dispensings (OR, 0.90; 95% CI, 0.81–0.99; P = 0.04). There were no differences in asthma-related hospitalizations (OR, 0.91; 95% CI, 0.66–1.24; P = 0.52).Conclusions: Among statin users with asthma, statin exposure was associated with decreased odds of asthma-related emergency department visits and oral corticosteroid dispensings.
Minimum left ventricular pressure during beta-adrenergic stimulation in human subjects. Evidence for elastic recoil and diastolic "suction" in the normal heart.
Authors: J E Udelson, S L Bacharach, R O Cannon, R O Bonow
Journal: Circulation (1990)

The influence of elastic recoil and restoring forces on diastolic left ventricular pressure decay and minimum left ventricular pressures has been demonstrated in animal models but has not been studied in the human heart. To investigate this issue in the normal human left ventricle, we studied eight patients with chest pain and normal coronary arteries with simultaneous measurement of left ventricular volume (by radionuclide angiography) and pressure (by micromanometer catheter) and coronary sinus blood flow. Electrocardiographic-gated data were obtained in the basal state, during rapid atrial pacing, and during isoproterenol infusion to a similar heart rate. Compared with pacing, isoproterenol increased ejection fraction and reduced end-systolic volume (p less than 0.005), end-systolic pressure (p less than 0.005), and the half-time of pressure decline after peak negative dP/dt (T1/2) (p less than 0.001). Negative diastolic pressure developed in seven of eight patients during isoproterenol (range, -0.5 to -2.4 mm Hg) but in only one of eight during pacing (-0.2 mm Hg). These reduced diastolic pressures during isoproterenol were accompanied by increased stroke volume (reflecting increased transmitral flow) and diminished pulmonary wedge pressure (reflecting left atrial pressure). The magnitude of reduction in minimum diastolic pressure during pacing and isoproterenol was related to the change in end-systolic volume (r = 0.79, p less than 0.001), ejection fraction (r = -0.74, p less than 0.001), T1/2 (r = -0.57, p less than 0.02), and coronary sinus flow (r = 0.73, p less than 0.005). Stronger correlations were observed in analyzing changes during isoproterenol alone.(ABSTRACT TRUNCATED AT 250 WORDS)
Salivary electrolytes in digitalis toxicity
Authors: S. Vaisrub
Journal: JAMA (1973)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Why Short-Term Psychotherapy for Borderlines?
Authors: Miguel A. Leibovich
Journal: Psychotherapy and Psychosomatics (1983)

This paper outlines general concepts for the utilization of short-term integrative psychotherapy for borderline personalities. It attempts to understand the rationale underlying the application of this therapeutic technique. In arriving at this understanding, consideration should be given to: (1) the technical aspects specific to the briefer procedures such as: time, acceptability, expectations, therapist's activity, focused approach, therapist as a real person, emphasis on patient's determination, withdrawal and regression, and (2) the particular symptomatic and characterological manifestations of this patient population such as: autonomy, relationships, structure and controls, choice, engulfment drives, fantasied universe, reality and ego functions.
Autonomic imbalance and immune activation in chronic heart failure — Pathophysiological links
Authors: E JANKOWSKA, P PONIKOWSKI, M PIEPOLI, W BANASIAK, S ANKER, P POOLEWILSON
Journal: Cardiovascular Research (2006)

Activation of the immune system and derangement of cardiorespiratory neural control are established elements of the complex pathophysiology of chronic heart failure (CHF). The magnitude of these abnormalities relates to disease progression and mortality. Less clear is the origin of these derangements and the sequence of triggering mechanisms in the course of the natural history of CHF. To date, immune activation and autonomic imbalance have been considered independently; we hypothesise they are closely related. Damaged heart muscle through autonomic afferents triggers functional and structural changes in the central nervous system, in part related to inflammatory processes. The altered function of the autonomic centres is expressed as a reduction of central parasympathetic tone. Diminished cholinergic signalling (mainly nicotinergic) activates inflammation and stimulates immune response. These two phenomena predict prognosis and represent therapeutic targets in the syndrome of CHF.
ROS regulation of microdomain Ca2+ signalling at the dyads
Authors: Huiliang Zhang, Ana M. Gomez, Xianhua Wang, Yuan Yan, Ming Zheng, Heping Cheng
Journal: Cardiovascular Research (2013)

Reactive oxygen species (ROS) are emerging as centre-stage players in cardiac functional regulation. ROS and Ca2+ signals converge at dyads, the structural and functional units of cardiac excitation–contraction coupling. These two prominent signalling systems are intertwined with ROS modulation of the entire Ca2+-signalling network, and vice versa. While constitutively generated homoeostatic ROS are important in setting the redox potential of the intracellular milieu, dynamic signalling ROS shape microdomain and global Ca2+ signals on both the beat-to-beat and greater time scales. However, ROS effects are complex and subtle, characterized by multiphasic and bidirectional Ca2+ responses; and sustained oxidative stress may lead to compromised contractility and arrhythmogenicity. These new understandings should be leveraged to harness ROS for their beneficial roles while avoiding deleterious effects in the heart.
Elevated Levels of C-Reactive Protein at Discharge in Patients With Unstable Angina Predict Recurrent Instability
Authors: Luigi M. Biasucci, Giovanna Liuzzo, Rita L. Grillo, Giuseppina Caligiuri, Antonio G. Rebuzzi, Antonino Buffon, Francesco Summaria, Francesca Ginnetti, Giovanni Fadda, Attilio Maseri
Journal: Circulation (1999)

Background —In a group of patients admitted for unstable angina, we investigated whether C-reactive protein (CRP) plasma levels remain elevated at discharge and whether persistent elevation is associated with recurrence of instability. Methods and Results —We measured plasma levels of CRP, serum amyloid A protein (SAA), fibrinogen, total cholesterol, and Helicobacter pylori and Chlamydia pneumoniae antibody titers in 53 patients admitted to our coronary care unit for Braunwald class IIIB unstable angina. Blood samples were taken on admission, at discharge, and after 3 months. Patients were followed for 1 year. At discharge, CRP was elevated (&gt;3 mg/L) in 49% of patients; of these, 42% had elevated levels on admission and at 3 months. Only 15% of patients with discharge levels of CRP &lt;3 mg/L but 69% of those with elevated CRP ( P &lt;0.001) were readmitted because of recurrence of instability or new myocardial infarction. New phases of instability occurred in 13% of patients in the lower tertile of CRP (≤2.5 mg/L), in 42% of those in the intermediate tertile (2.6 to 8.6 mg/L), and in 67% of those in the upper tertile (≥8.7 mg/L, P &lt;0.001). The prognostic value of SAA was similar to that of CRP; that of fibrinogen was not significant. Chlamydia pneumoniae but not Helicobacter pylori antibody titers significantly correlated with CRP plasma levels. Conclusions —In unstable angina, CRP may remain elevated for at ≥3 months after the waning of symptoms and is associated with recurrent instability. Elevation of acute-phase reactants in unstable angina could represent a hallmark of subclinical persistent instability or of susceptibility to recurrent instability and, at least in some patients, could be related to chronic Chlamydia pneumoniae infection.
Potential Impact of Postoperative Early Complications on the Timing of Adjuvant Chemotherapy in Patients Undergoing Radical Cystectomy: A High-Volume Tertiary Cancer Center Experience
Authors: S. Machele Donat, Ahmad Shabsigh, Caroline Savage, Angel M. Cronin, Bernard H. Bochner, Guido Dalbagni, Harry W. Herr, Matthew I. Milowsky
Journal: European Urology (2008)
AID expression identifies interfollicular large B cells as putative precursors of mature B-cell malignancies
Authors: Gerhard Moldenhauer, Sergey W. Popov, Beate Wotschke, Silke Brüderlein, Petra Riedl, Nicolas Fissolo, Reinhold Schirmbeck, Olga Ritz, Peter Möller, Frank Leithäuser
Journal: Blood (2005)
Papaverine and regional myocardial function
Authors: W. Schlack, S. Schafer, V. Thamer
Journal: Cardiovascular Research (1994)

Journal Article Papaverine and regional myocardial function Get access Wolfgang Schlack, Wolfgang Schlack Search for other works by this author on: Oxford Academic PubMed Google Scholar Stefan Schafer, Stefan Schafer *Department of Cardiology, Heinrich-Heine-Universitat, Diisseldorf, Germany. Search for other works by this author on: Oxford Academic PubMed Google Scholar Volker Thamer Volker Thamer Search for other works by this author on: Oxford Academic PubMed Google Scholar Cardiovascular Research, Volume 28, Issue 3, March 1994, Page 434, https://doi.org/10.1093/cvr/28.3.434 Published: 01 March 1994
Chylothorax and Chyloperitoneum
Authors: Thai Yen Ly, Robert A. Fowler
Journal: New England Journal of Medicine (2006)

A 76-year-old man underwent elective repair of an abdominal aortic aneurysm, and in the subsequent eight weeks, exertional dyspnea, orthopnea, and abdominal pain developed. On physical examination, the patient was afebrile, and his vital signs were normal. There was a dull percussion note and decreased breath sounds over the right lower lung field. The abdomen was protuberant and diffusely tender. The serum triglyceride level was 1.21 mmol per liter (normal, <1.70 mmol per liter). A chest radiograph demonstrated a right pleural effusion (Panel A). Computed tomography of the abdomen revealed gross ascites containing particulate matter but no other abnormalities. Subsequent . . .
Roentgen Appearance of the Hand in Diffuse Disease
Authors: Joseph E. Whitley
Journal: JAMA (1975)

The roentgenographic image of the hand and wrist is capable of portraying bone and soft tissue in exquisite detail with a relatively low expense and radiation hazard. The proper analysis of this image can substantiate or primarily lead to the diagnosis of many inborn and acquired diseases. This text is proffered as a comprehensive reference and guide to diseases that have diffuse involvement visible in roentgenograms of the hand. Localized diseases are excluded.  Four hundred thirty-eight pages of the book are narrative. Each entity is succinctly defined, the clinical and roentgenographic features are detailed, and pertinent references are included. A brief discussion of pathogenesis and/or differential diagnosis is frequently included.  The remaining 212 pages are an atlas of roentgenographic reproductions of the hand and wrist with descriptive legends. Not only the typical roentgenographic appearance of a disease is portrayed, but frequently, a spectrum of appearances in different age groups, and
Myocardial Blood Flow and Oxygen Consumption in Man Early After Valve Replacement
Authors: JAMES D. WISHEART, JOSEPH P. ARCHIE, JOHN W. KIRKLIN, WILLIAM G. TRACY
Journal: Circulation (1974)

Twenty-one patients without demonstrable coronary artery disease have been studied in the first 48 hours after aortic or mitral valve replacement to determine the possible contribution of abnormalities of left ventricular myocardial blood flow and oxygen consumption to the impaired cardiac performance which is sometimes evident in such patients. In the 14 patients making an uneventful recovery (group A), the mean value for left ventricular coronary blood flow (Kety-Schmidt method) in each study period was between 105.9 and 111.2 ml·min –1 ·100 g –1 , and myocardial oxygen consumption between 11.1 and 12.7 ml·min –1 ·100 g –1 , both being higher than in normal resting man. Oxygen extraction was 59 to 69%, and coronary sinus oxygen tension 23 to 29 mm Hg. Lactate extraction was normal. Five patients (group B) required pharmacologic support because of low cardiac output; all had undergone mitral valve replacement. In them, left ventricular coronary blood flow and oxygen consumption were the same as in group A; however, oxygen extraction was greater (68 to 79%), coronary sinus oxygen tension lower (22 to 24 mm Hg) and lactate extraction lower. Patients in group A who underwent mitral replacement (N = 4) had systemic and coronary hemodynamics and metabolism that were as satisfactory as those undergoing aortic replacement, except that left atrial pressure was higher in the first study period. When heart rate was increased from 100 to 128 beats/minute by pacing in five patients in group A, and in two additional patients, myocardial oxygen consumption increased significantly, but in four patients coronary blood flow failed to increase, oxygen extraction increased, and coronary sinus oxygen levels decreased. We conclude that in patients such as those we studied, low cardiac output postoperatively is not the result of low total left ventricular coronary blood flow or myocardial oxygen supply, but may occur in some of these patients at this time from low or absent coronary reserve and added stresses such as those from tachycardia may be met only with the potentially detrimental mechanism of increasing oxygen extraction and reducing coronary venous and myocardial oxygen levels.
TCT-114 Impact of Left Ventricular Function on Outcomes of Transcatheter Aortic Valve Replacement and Medical Therapy in Inoperable Patients with Aortic Stenosis: Insights from the Placement of Aortic Transcatheter Valves (PARTNER) Trial (Cohort B)
Authors: Sammy Elmariah, Igor F. Palacios, Tom McAndrew, Ignacio Inglessis, Joshua N. Baker, Gus J. Vlahakes, Maureen A. Daher, Susheel Kodali, Martin Leon, Lars Svensson, Philippe Pibarot, Pamela Douglas, Ajay J. Kirtane, Jonathan J. Passeri
Journal: Journal of the American College of Cardiology (2013)