OBSERVATIONS ON THE TREATMENT OF GRAVES' DISEASE WITH THIOURACIL
Authors: DAVID P.  BARR, EPHRAIM  SHORR
Journal: Annals of Internal Medicine (1945)

Article1 November 1945OBSERVATIONS ON THE TREATMENT OF GRAVES' DISEASE WITH THIOURACILDAVID P. BARR, M.D., F.A.C.P., EPHRAIM SHORR, M.D.DAVID P. BARR, M.D., F.A.C.P.Search for more papers by this author, EPHRAIM SHORR, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-23-5-754 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptOver two years have elapsed since Astwood1first reported his observations on the use of thiouracil in a patient with thyrotoxicosis. It is now well known that the drug has a remarkable effect in preventing the formation of thyroid hormone and that its clinical use may cause striking improvement in the symptoms of Graves' disease. Unfortunately experience has also shown that the drug possesses some serious toxic properties and especially a tendency to cause granulocytopenia or even fatal agranulocytosis. It is not yet established whether it is safe for general use, whether under any circumstances its use constitutes a permanent...Bibliography1. ASTWOOD EB: Treatment of hyperthyroidism with thiourea and thiouracil, Jr. Am. Med. Assoc., 1943, cxxii, 78. CrossrefGoogle Scholar2. KENNEDY TH: Thioureas as goitrigenic substances, Nature, 1942, cl, 233. CrossrefGoogle Scholar3. MACKENZIEMACKENZIE CJJB: Effect of sulfonamides and thiourea on the thyroid gland and basal metabolism, Endocrinology, 1943, xxxii, 185. CrossrefGoogle Scholar4. WILLIAMSCLUTE RHHM: Thiouracil in the treatment of thyrotoxicosis, New England Jr. Med., 1944, ccxxx, 657. CrossrefGoogle Scholar5. SOLEY MH: Exophthalmos in patients with various types of goiter, Arch. Int. Med., 1942, lxx, 206. CrossrefGoogle Scholar6. RICH AR: Role of hypersensitivity in periarteritis nodosa as indicated by 7 cases developing during serum sickness and sulfonamide therapy, Bull. Johns Hopkins Hosp., 1942, lxxi, 123. Google Scholar7. SLOANSHORR MHE: Metabolic effects of thiouracil in Graves' disease, Science, 1944, xcix, 305. CrossrefGoogle Scholar8. ASTWOOD EB: Thiouracil treatment in hyperthyroidism, Jr. Clin. Endocrinol., 1944, iv, 229. CrossrefGoogle Scholar9. GOLDSMITHGORDENCHARIPPEN EDASHA: An analysis of the effects of continued thiourea treatment in pregnancy and on the development of the offspring in the rat, Am. Jr. Obst. and Gynec., 1945, xlix, 197. CrossrefGoogle Scholar10. EATON JC: Treatment of thyrotoxicosis with thiouracil, Lancet, 1945, i, 171. CrossrefGoogle Scholar11. PRESTONTHOMPSON JWWO: Persistence and recurrence of toxic goiter following subtotal thyroidectomy, Arch. Int. Med., 1942, lxix, 1019. CrossrefGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: New York, N. Y.*Received for publication August 6, 1945.From the Department of Medicine, Cornell University Medical College; and the New York Hospital. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byThe Chronology of Graves' Ophthalmopathy in an Incidence CohortEndocrine ExophthalmosREFERENCESTHE VALUE OF LEUCOCYTE-COUNTS IN THIOURACIL MEDICATIONPharmakologie der Schilddr�sent�tigkeitDrug allergyPersistence of Remissions of Thyrotoxicosis after Cessation of Thiouracil TherapyThiouracil: Remission or relapse of hyperthyroidism after discontinuing its useTreatment of Hyperthyroidism with Methylthiouracil.THIOURACIL DERIVATIVES AND PREGNANCY1The Biology of Antithyroid AgentsTHIOURACILDENTAL RESEARCH UNIT FOR LONDONClinical Use of Thiouracil 1 November 1945Volume 23, Issue 5Page: 754-778KeywordsDrugsHospital medicineThyroid hormones ePublished: 1 December 2008 Issue Published: 1 November 1945 PDF downloadLoading ...