tbuckley/cabot-search huggingface dataset:
Abstract 13941: Combined Assessment of Right Ventricular Function and Reverse Remodeling as Prognostic Marker after Administration of Medical Treatment for Pulmonary Hypertension
Authors: Hiroyuki Sano, Hidekazu Tanaka, Yoshiki Motoji, Yuko Fukuda, Kumiko Dokuni, Yutaka Hatani, Keiko Hatazawa, Hiroki Matsuzoe, Hiromi Toki, Hiroyuki Shimoura, Junichi Ooka, Takuma Sawa, Yasuhide Mochizuki, Kazuhiro Tatsumi, Kensuke Matsumoto, Noriaki Emoto, Ken-ichi Hirata
Journal: Circulation (2014)

Background: Right ventricular (RV) dysfunction plays an important role in disease progression and prognosis of patients with pulmonary hypertension (PH). However, the association of RV reverse remodeling with long-term outcomes remains unclear. Our objective was thus to test the hypothesis that mid-term RV reverse remodeling after adding PH-specific drugs was linked to long-term outcomes in patients with PH. Methods: We studied 45 PH patients with resting mean pulmonary artery pressure (mPAP) of 35±10mmHg. PH patients with chronic thromboembolic pulmonary hypertension and left-sided heart failure including pulmonary capillary wedge pressure of &gt;15mmHg were excluded. Echocardiography was performed at enrollment and mid-term of 5.7±4.1 months after adding PH-specific drugs. RV function was calculated by averaging the three regional peak speckle-tracking longitudinal strains from RV free-wall (RV-free). RV remodeling was assessed in terms of the RV area, which was traced planimetrically at the end-systole (RVESA) from RV-focused apical 4-chamber views. Mid-term RV reverse remodeling was defined as a relative decrease in RVESA of at least 15%. Long-term event-free survival was then tracked for 5 years. Results: Patients with mid-term RV reverse remodeling experienced favorable long-term outcomes than those without mid-term RV reverse remodeling (log-rank p&lt;0.01). The incremental benefit using sequential Cox models in the prediction of long-term outcomes showed that a model based on clinical variables including mPAP and pulmonary vascular resistance (PVR) was improved by addition of RV-free (p=0.03), and further improved by addition of the parameter of mid-term RV reverse-remodeling (p=0.01). Conclusion: Mid-term RV reverse remodeling after adding PH-specific drugs was associated with long-term outcomes, and this combined approach may well have clinical implications for better management of PH patients.
Evaluation of primary prevention initiatives for skin cancer: a review from a U.K. perspective
Authors: J. Melia, L. Pendry, J.R. Eiser, C. Harland, S. Moss
Journal: British Journal of Dermatology (2000)

To ensure effective primary prevention of skin cancer, aimed at changing behaviour in the sun, and ultimately at reducing the incidence and mortality rates from skin cancer, sufficient information needs to be known about the relationship between sun exposure and skin cancer, the effectiveness of sun protection measures, and the acceptability and uptake of protective measures by the general public. This review specifically addresses the quality and outcome of studies designed to evaluate the impact of primary prevention initiatives in the U.K. Four main areas of concern are highlighted: (i) teenage behaviour in the sun is difficult to change; (ii) fashion, in part, dictates adult and adolescent behaviour in the sun; (iii) there are practical problems related to response rates, follow-up and interpretation of self-reported behaviour; and (iv) a strategy for primary prevention in the U.K. may be falsely based on the experience and results of Australian and American programmes. Standardized methods for monitoring general population behaviour are needed in the U.K. Evaluation of interventions targeting specific groups, especially parents and young children, and the relative costs of different strategies should be reported. Primary prevention messages and strategies should be adapted to the type of ultraviolet radiation exposure experienced, and the overall low risk of melanoma, while addressing controversies on the health effects of sun exposure and sun screens.
The Safety of Prescription Drugs
Authors: Joshua M. Sharfstein, Aaron S. Kesselheim
Journal: JAMA (2015)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Amino-Terminal Pro-Brain Natriuretic Peptide, Renal Function, and Outcomes in Acute Heart Failure
Authors: Roland R.J. van Kimmenade, James L. Januzzi, Aaron L. Baggish, John G. Lainchbury, Antoni Bayes-Genis, A. Mark Richards, Yigal M. Pinto
Journal: Journal of the American College of Cardiology (2006)
Abstract 16159: The Biomarker Tissue Inhibitor of Metalloproteinase-1 (TIMP-1) is a Stronger Independent Predictor of All-Cause Mortality Than Other Established Biomarkers in the AGES-Reykjavik Study
Authors: Gina LaRocca, Anders Greve, Thor Aspelund, Gudny Eiriksdottir, Lenore J Launer, Tamara B Harris, Vilmundur Gudnason, Andrew E Arai
Journal: Circulation (2014)

Objectives:  Biomarkers matrix metalloproteinase-9 (MMP-9), and tissue inhibitor of metalloproteinase-1 (TIMP-1), relate to remodeling of the extracellular matrix. The imbalance of these proteins leads to tissue destruction, proteolysis, synthesis of cytokines, and inflammation. We therefore, hypothesized that MMP-9 and TIMP-1 would predict all-cause mortality independent of other well-established biomarkers in the AGES-Reykjavik Study (Age Gene/Environment Susceptibility- Reykjavik Study).   Methods:  Participants in this study represent 5491 of the 5,764 community-dwelling men and women characterized by the AGES-Reykjavik Study and followed by the Icelandic Heart Association since 1967. We measured MMP-9 and TIMP-1 using an ELISA assay in citrate plasma, creatinine for estimated glomerular filtration rate (eGFR), and serum high sensitivity C-reactive protein (hs-CRP). Multivariable Cox regression was used to evaluate rate ratios for all-cause mortality according to 50th, 75th and 95th percentiles of TIMP-1. Chi-square values were used to compare the relative prognostic strength between TIMP-1 and other covariates to all-cause mortality.   Results:  At the time of blood sampling, the mean age was 77 years (range 66-98); 42% were male; hypertension was treated in 64%, diabetes was present in 13%, and 12% were active smokers. Of the participants, 34% died (N=1871) with a median follow-up of 8 years. Among all covariates independently associated with all-cause mortality, the overall effect of TIMP-1 percentiles emerged as the strongest covariate after age (Table 1). Fully adjusted, the upper 5th percentile of TIMP-1 remained at a nearly 3-fold increased risk of dying as compared to the lowest 50th percentile (HR 2.5 (2.2 - 3.0), p   Conclusion:  TIMP-1 is independently associated with increased risk of all-cause mortality in older community dwelling subjects and was the strongest biomarker of any studied.
PLC-β1, activated via mGluRs, mediates activity-dependent differentiation in cerebral cortex
Authors: Anthony J. Hannan, Colin Blakemore, Alla Katsnelson, Tania Vitalis, Kimberly M. Huber, Mark Bear, John Roder, Daesoo Kim, Hee-Sup Shin, Peter C. Kind
Journal: Nature Neuroscience (2001)
Primer on Laser Angioplasty
Authors: Robert Ginsburg, Herbert J. Geschwind
Journal: Annals of Internal Medicine (1989)

Focusing on the use of percutaneous excimer laser coronary angioplasty, this book provides a basic foundation in lasers and their application to cardiovascular disease for physicians who have little familiarity or limited experience with laser therapy. This second edition also gives information and suggests concepts to simulate solutions to unsolved clinical problems.
A Role for Ceramide in AdGFPFasLTET Gene Therapy
Authors: James S. Norris, David H. Holman, Ahmed M. El-Zawahry, David A. Schwartz, Alicja Bielawska, Lina M. Obeid, Yusuf A. Hannun, Jian-Yun Dong
Journal: Molecular Therapy (2004)

Top of pageAbstract
The application of gene therapy to cancer has many options in the choice of therapeutic genes but delivery of a corrective signal to every cell in the cancer is impossible. Thus, studies on improving the delivery of therapeutic genes or how to amplify the therapeutic response to gene therapy are urgently needed. In the DU145 model of prostate cancer, resistance to induction of apoptosis via Fas receptor signaling is due to overexpression of apoptotic resistance genes including cFLIPs [Hyer et al., Can Biol. and Ther. 1(4): 405–410, 2002]. We have also determined that expression of a FasL-GFP fusion gene overcomes resistance in infected cells [Hyer et al., Mol. Ther. 2(4):348–358, 2000] and kills the cell apoptotically. During this process apoptotic vesicles that signal through Fas to induce apoptosis are also produced and can be demonstrated to exert bystander activity [Hyer et al., Can. Gene Ther. 10(4):330–339, 2003]. DU145 cells overexpress apoptotic resistance genes and acid ceramidase (i.e. lowers ceramide levels), which we have shown (unpublished) produces a FasL resistant phenotype and reduces the bystander effects. This led us to examine the role of ceramide elevation in the bystander process by using small molecule ceramidase inhibitors. We have now demonstrated that acid ceramidase inhibitors, are highly efficient at activating cell death in DU145 cells in vitro using nontoxic doses in combination with AdGFPFasL virus at MOIs achievable in vivo. Administration of inhibitors activates proteasome function and transiently elevates ceramide. Mitochondrial depolarization also is observed. In vivo experiments using 75mg/kg of acid ceramidase inhibitor and AdGFPFasL provides real support for this combined gene therapy/small molecule therapy approach. We will present selected data at the meeting that explain, in part, the mechanisms of this combined therapy.
The sexual health of boys and men
Authors: M. A Bellis
Journal: BMJ (2000)

This article discusses the importance of commercial advertisements in promoting sexual health of boys and men by creating a condom culture in the UK.  It was noted that in the UK sexually transmitted infections (STIs) in young people are increasing and there are about 90000 teenage conceptions a year being recorded. The report can be considered as an impact of limited success in health promotion; however using commercial advertisements to promote particular condom brands could have prevented the problem. Although education and health bodies have already made condoms more available to young people and developed an understanding of their health benefits but without a cultural move making condom use popular the problem will continue to exist.  Moreover the restrictions placed on advertising condom are a significant factor that led to the problem.  Therefore pragmatic revisions to existing rules on the commercial advertising should be done in order to help reduce STIs and unwanted pregnancies.
757. Enhancement of Gene Expression by a Recombinant Adeno-Associated Virus by Various Chemical Treatments
Authors: Sung Jin Kim, Young Ran Nam, Chul-Hyen Joo, Jin Woo Chang, Yoo-Kyum Kim, Heuiran Lee
Journal: Molecular Therapy (2004)

A recombinant adeno-associated virus (rAAV) has drawn attention as a novel gene delivery system with the advantage of long-term and efficient gene expression, particularly in neuronal and skeletal muscle cells. However, transduction efficiency (TE) by rAAV is still low, which may explain its limited application, even in neuronal cells in vitro. To overcome this drawback of rAAV system, we attempted to enhance the transduction efficacy using many different kinds of chemicals, mostly modulating DNA synthesis, cell cycle or rAAV receptor expression. To investigate the effects of various chemical treatments on TE, we infected several human cancer cells lines (cervical Hela, colon HCT 116, breast MCF-7, hepatocellular carcinoma SK-Hep1, and glioma U 251 cancer cells) with rAAV-expressing b-galactosidase. We then examined the degree of x-gal staining 48 h after post-infection. Total 7 chemicals were employed to enhance TE by rAAV of Trichostatin A as an inducer of rAAV receptor expression, Aphidicolin and Hydroxyurea as a DNA damaging agent, Etopocide and Camptothecin as a DNA synthesis blocker, MG-132 as a proteosome inhibitor, and Tyrphostin-1 as a EGFR inhibitor. Hydorxyurea increased TE by 25- or 5-fold in Hela or HCT 116 cells, respectively. MG-132 increased TE by 8.5-fold in SK-Hep1 cells. Co-treatment of MG-132 and camptothecin enhanced TE by 12-fold in Hela cells. The combined treatment of hydroxyurea and tyrphostin-1 also enhanced the transduction efficiency by 12-fold in Hela cells. Finally, MTT assay consistently implied that the cytotoxicity was not observed in any concentrations of each chemical used in this study.
Drilling holes in the heart helps angina
Authors: Deborah Josefson
Journal: BMJ (2000)

Transmyocardial revascularisation, a controversial procedure in which a laser is used to drill tiny holes into the heart, provides symptomatic relief from refractory angina but does not improve cardiovascular function or reduce adverse ischaemic events, according to a new report (Journal of the American College of Cardiology 2000:35:1170-7).

The procedure, in which a laser is used to drill 30-50 holes into a beating ventricle, received provisional approval for refractory angina by the Food and Drug Administration in May 1998. About 5000 patients worldwide have undergone the procedure.

It was developed to provide an alternative route for blood to reach ischaemic myocardium. Typically, …
Abstract 17049: Obesity and Prognosis in Patients with Acute Cerebrovascular Accident
Authors: Sami Hayek, Nabil Zeineh, David Lasorda, Raef Hajjali
Journal: Circulation (2014)

Introduction: Limited data exist concerning the impact of obesity on prognosis in patients with acute cerebrovascular accident (CVA). Some of the published data suggest a paradoxically better outcome in obese patients with CVA while others have failed to find such an association and this relation remains unclear. Hypothesis: We examined the impact of obesity on in-hospital mortality in patients presenting with acute ischemic CVA in a large sample representative of the US population. Methods: The Nationwide Inpatient Sample, part of the Healthcare Cost and Utilization Project, is the largest publicly available inpatient database designed to provide information on characteristics and outcomes of patients discharged from United States community hospitals. Using the Nationwide Inpatient Sample, we identified 455006 adult patient discharges, with a primary discharge diagnosis of ischemic stroke or TIA. Among those, 31723 had a diagnosis of obesity. Results: Patients with obesity were in general younger (63 yrs. vs. 72 yrs. p&lt;0.001), with a higher proportion of females (57% vs. 52%, p&lt;0.001), and a higher frequency of hypertension (71% vs. 66%, p&lt;0.001), and diabetes mellitus (55% vs. 30%, p&lt;0.001. Obese patients were less likely to have atrial fibrillation (13% vs. 18%, p&lt; 0.001). The in-hospital mortality rate for patients with acute CVA and obesity was 1.8%, compared to 3.2% in patients without obesity (p&lt;0.001). After adjusting for pertinent clinical variables using logistic regression analysis, obesity remained an independent predictor of lower in-hospital mortality (p&lt;0.001, OR 0.82[0.75-0.89]). Conclusions: In patients presenting with acute cerebrovascular accident, obesity is associated with lower in-hospital mortality.
Interactions between the effects of a 4-week NO2 and carbon nanoparticle exposure with allergen sensitization on bronchial responsiveness in Brown Norway rat
Authors: Skander Layachi, Françoise Rogerieux, Christelle Gamez, Kelly Blazy, Franck Robidel, Anthony Lecomte, Ghislaine Lacroix, Sam Bayat
Journal: European Respiratory Journal (2011)

Goals: The aim of this study was to assess the effect of combinations of allergen sensitization, NO2 and carbon nanoparticle (CNP) exposure on airway reactivity (AR).

Methods: Brown-Norway rats were divided into the following groups: Control, CNP (FW2: O13nm, 0,5mg/kg) instilled intratracheally x3 at 7-day intervals, ovalbumine-sensitised (OVA), and CNP+OVA. Equal groups of animals were exposed either to air or to NO2, 10 ppm, 5h/d, 5d/wk for 4 weeks. 24h after exposure, airway resistance (Raw) was measured using forced oscillation technique (FOT) at baseline and after intravenous infusion of methacholine (MCH) (5-10 and 15 μg/kg/min (γ)). Bronchoalveolar lavage fluid (BALF) cell counts were obtained.

Results: See Table 1.

View this table:

Table 1





Conclusions: NO2 exposure and allergen sensitization caused a synergistic increase in AR. However, CNP exposure during the sensitization process decreased this effect. The observed interactions may be due to different inflammatory mechanisms induced by CNP and NO2.
Selection on stability across ecological scales
Authors: Jonathan J. Borrelli, Stefano Allesina, Priyanga Amarasekare, Roger Arditi, Ivan Chase, John Damuth, Robert D. Holt, Dmitrii O. Logofet, Mark Novak, Rudolf P. Rohr, Axel G. Rossberg, Matthew Spencer, J. Khai Tran, Lev R. Ginzburg
Journal: Trends in Ecology & Evolution (2015)
Efficacy and safety of cyclic pyranopterin monophosphate substitution in severe molybdenum cofactor deficiency type A: a prospective cohort study
Authors: Bernd C Schwahn, Francjan J Van Spronsen, Abdel A Belaidi, Stephen Bowhay, John Christodoulou, Terry G Derks, Julia B Hennermann, Elisabeth Jameson, Kai König, Tracy L McGregor, Esperanza Font-Montgomery, José A Santamaria-Araujo, Saikat Santra, Mamta Vaidya, Anne Vierzig, Evangeline Wassmer, Ilona Weis, Flora Y Wong, Alex Veldman, Günter Schwarz
Journal: The Lancet (2015)
Safety and Cost Effectiveness of a 10 × 109/L Trigger for Prophylactic Platelet Transfusions Compared With the Traditional 20 × 109/L Trigger: A Prospective Comparative Trial in 105 Patients With Acute Myeloid Leukemia
Authors: Hannes Wandt, Markus Frank, Gerhard Ehninger, Christiane Schneider, Norbert Brack, Ali Daoud, Irene Fackler-Schwalbe, Jürgen Fischer, Ringfried Gäckle, Thomas Geer, Peter Harms, Birgit Löffler, Siegfried Öhl, Burkhard Otremba, Monika Raab, Petra Schönrock-Nabulsi, Gerhard Strobel, Rolf Winter, Hartmut Link
Journal: Blood (1998)
SRSF2 Mutations Contribute to Myelodysplasia by Mutant-Specific Effects on Exon Recognition
Authors: Eunhee Kim, Janine O. Ilagan, Yang Liang, Gerrit M. Daubner, Stanley C.-W. Lee, Aravind Ramakrishnan, Yue Li, Young Rock Chung, Jean-Baptiste Micol, Michele E. Murphy, Hana Cho, Min-Kyung Kim, Ahmad S. Zebari, Shlomzion Aumann, Christopher Y. Park, Silvia Buonamici, Peter G. Smith, H. Joachim Deeg, Camille Lobry, Iannis Aifantis, Yorgo Modis, Frederic H.-T. Allain, Stephanie Halene, Robert K. Bradley, Omar Abdel-Wahab
Journal: Cancer Cell (2015)
Safety of Newer Antiepileptic Drugs
Authors: Judith A. Racoosin, James F. Knudsen
Journal: JAMA (2004)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Structure-based Design of Peptides with High Affinity and Specificity to HER2 Positive Tumors
Authors: Lingling Geng, Zihua Wang, Xiaoliang Yang, Dan Li, Wenxi Lian, Zhichu Xiang, Weizhi Wang, Xiangli Bu, Wenjia Lai, Zhiyuan Hu, Qiaojun Fang
Journal: Theranostics (2015)

To identify peptides with high affinity and specificity against human epidermal growth factor receptor 2 (HER2), a series of peptides were designed based on the structure of HER2 and its Z(HER2:342) affibody.By using a combination protocol of molecular dynamics modeling, MM/GBSA binding free energy calculations, and binding free energy decomposition analysis, two novel peptides with 27 residues, pep27 and pep27-24M, were successfully obtained.Immunocytochemistry and flow cytometry analysis verified that both peptides can specifically bind to the extracellular domain of HER2 protein at cellular level.The Surface Plasmon Resonance imaging (SPRi) analysis showed that dissociation constants (K D ) of these two peptides were around 300 nmol/L.Furthermore, fluorescence imaging of peptides against nude mice xenografted with SKBR3 cells indicated that both peptides have strong affinity and high specificity to HER2 positive tumors.
587. Further Advances in Immuno-Gene Therapy Against Human Papillomavirus by Adeno-Associated Virus Gene Transfer into Dendritic Cells
Authors: Yong Liu, Maurizio Chiriva-Internati, Hong You, Jawahar L. Mehta, Paul L. Hermonat
Journal: Molecular Therapy (2004)

Recent studies demonstrate that recombinant adeno-associated virus (rAAV)-based antigen-loading of dendritic cells (DC) generates significant and rapid (one stimulation/one week) cytotoxic T lymphocyte (CTL) responses in vitro against viral and self antigens. To further improve this already potent technique we compared co-infection of an AAV/antigen vector, AAV/HPV-E6/Neo, with a rAAV vector carrying one of four cytokines. These included interleukin (IL)-2, interferon (IFN) gamma, granulocyte macrophage-colony stimulating factor (GM-CSF) and IL-7. Previously we have shown that the delivery of the GM-CSF gene into DC resulted in secretion of this transgene cytokine. Furthermore the freshly secreted cytokine had a 100–1000 fold higher biological activity on a per weight basis compared to recombinant commercial exogenously added cytokine. Here, in a head-to-head comparison the delivery of the IL-7 gene appeared superior to IL-2 and IFN-gamma for improving CTL response. In a second comparison the infection of DC by IL-7 was compared to the direct infection of T cells. In a head-to-head comparison the direct delivery/infection of IL-7 into the T cell population generated significantly higher levels of killing of E7-positive target cells. These data suggest that the use of cytokine genes can improve CTL response and also suggests that a number of further procedural improvements can be made.