tbuckley/cabot-search huggingface dataset:
Co-trimoxazole and Azathioprine: A Safe Combination
Authors: C. L. Hall
Journal: BMJ (1974)

Ninety-four patients receiving immunosuppressive therapy with azathioprine and prednisone after human cadaver kidney transplantation developed urinary tract infections and were treated with co-trimoxazole or another antibiotic in a controlled randomized prospective trial. The incidence of leucopenia in the group treated with co-trimoxazole (10·6%) was not significantly different from that in the group treated with other antibiotics (23·6%). Leucopenia when it occurred did so soon after transplantation at a time when the function of the renal transplant was poor in relation to the dosage of azathioprine given. In all cases the temporary withdrawal of azathioprine relieved the leucopenia despite continuation of the co-trimoxazole treatment. This study did not provide any evidence that co-trimoxazole plus azathioprine was a more potent cause of leucopenia than azathioprine alone.
Development of pancreatic cancers during long-term follow-up of side-branch intraductal papillary mucinous neoplasms
Authors: Y. Sawai, K. Yamao, V. Bhatia, T. Chiba, N. Mizuno, A. Sawaki, K. Takahashi, M. Tajika, Y. Shimizu, Y. Yatabe, A. Yanagisawa
Journal: Endoscopy (2010)

Corrected by: Development of pancreatic cancers during long-term follow-up of side-branch intraductal papillary mucinous neoplasmsEndoscopy 2011; 43(01): 79-79DOI: 10.1055/s-0030-1256071
Resolution of Chronic Hepatitis B after Ritonavir Treatment in an HIV-Infected Patient
Authors: Maria Velasco, Aurora Morán, María Jesús Téllez
Journal: New England Journal of Medicine (1999)

To the Editor: Dr. Darouiche and colleagues (Jan.7 issue) 1 conclude that the use of central venous catheters impregnated with minocycline and rifampin is associated with a lower rate of catheter-related bloodstream infection than the use of catheters impregnated with chlorhexidine and silver sulfadiazine.They defined a catheter-related bloodstream infection by the isolation of the same organism from the vascular catheter and from peripheral blood in a patient with sepsis and no other apparent source of bloodstream infection.However, residual antimicrobial activity in the removed catheter sufficient to prevent growth from the cultured catheter segments would substantially reduce the apparent rate of catheter-related bloodstream infections (since a catheter-related bloodstream infection cannot occur on the basis of this definition if no growth is recorded from the cultured catheter segments).The authors found no significant difference between groups in the proportion of catheters removed for suspected infection (14 percent of minocycline-rifampin catheters and 13 percent of chlorhexidine-silver sulfadiazine catheters), the proportion receiving vancomycin (23 percent vs. 25 percent), or the mean duration of stay in the intensive care unit (8.7 vs. 8.6 days).Thus, could it be that use of minocycline-rifampin impregnation prevents growth from catheters in the microbiology laboratory but does not eliminate the clinical syndrome of catheter-related bloodstream infection?
Reforming British primary care (again)
Authors: T. Groves
Journal: BMJ (1999)

Editorials p 748, General practice p 772, Education and debate p 797, Letters p 803

On 1 April all general practitioners in England and Wales will have to start working collaboratively in large local groups to commission and, in some cases, purchase secondary care for the populations they serve. 1 2 To general practitioners and many others in the NHS this is hardly hot news: they have been preparing for this shift since early last year. But, given that the NHS, and primary care in particular, has changed its structure so many times in the past decade, we thought that some BMJ readers could do with a little explanation.

In the early 1990s the Conservative government tried to contain increasing demand and rising costs in the NHS by splitting the service into provider trusts (hospitals and community and mental health services) and purchasers (health authorities and some general practitioners, called fundholders).3 Because general practitioner fundholding …
Nasal Vaccination,<i>Escherichia coli</i>Enterotoxin, and Bell's Palsy
Authors: Robert B. Couch
Journal: New England Journal of Medicine (2004)

In 1997, a Swiss Company (Berna Biotech) received approval to market an inactivated influenza vaccine for parenteral administration that consists of the hemagglutinin and neuraminidase surface antigens of influenzavirus incorporated into liposomes. This virosome vaccine was subsequently used in the formulation of an influenzavirus vaccine for intranasal administration. To optimize both mucosal and systemic immune responses to the nasal vaccine, heat-labile Escherichia coli enterotoxin, one of the most powerful mucosal adjuvants known, was included in the formulation. The clinical studies showed that clinically significant antibody responses to influenzavirus were elicited by this vaccine, as evidenced in both nasopharyngeal secretions and . . .
XERODEEMA PIGMENTOSUM OF MILD TYPE
Authors: T. E. ANDERSON, M. BEGG
Journal: British Journal of Dermatology (1950)

Journal Article XERODEEMA PIGMENTOSUM OF MILD TYPE Get access T. E. ANDERSON, T. E. ANDERSON Search for other works by this author on: Oxford Academic Google Scholar M. BEGG M. BEGG Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology and Syphilis, Volume 62, Issue 10, 1 October 1950, Pages 402–407, https://doi.org/10.1111/j.1365-2133.1950.tb14345.x Published: 01 October 1950
Comparison of Parkinson Risk in Ashkenazi Jewish Patients With Gaucher Disease and<i>GBA</i>Heterozygotes
Authors: Roy N. Alcalay, Tama Dinur, Timothy Quinn, Karina Sakanaka, Oren Levy, Cheryl Waters, Stanley Fahn, Tsvyatko Dorovski, Wendy K. Chung, Michael Pauciulo, William Nichols, Huma Q. Rana, Manisha Balwani, Louise Bier, Deborah Elstein, Ari Zimran
Journal: JAMA Neurology (2014)

Information on age-specific risk for Parkinson disease (PD) in patients with Gaucher disease (GD) and glucocerebrosidase (GBA) heterozygotes is important for understanding the pathophysiology of the genetic association and for counseling these populations.
Wait Times and Diagnostic Pathways among Women with Invasive Breast Cancer in a Population-Based Publicly Funded Cancer Centre, British Columbia, Canada.
Authors: L. Martin, B. Banno, M. Joffres, F. Wong, C. Sherriff
Journal: Cancer Research (2009)

Abstract Rationale and background: The Fraser Valley Cancer Center serves a large geographic population of urban and rural areas. Selected data on wait times and diagnostic pathways are available for mammography screening programs in British Columbia (BC), but not for patients presenting with clinical abnormalities such as a palpable breast lump. Diagnostic pathways in BC are managed by primary care physicians and community surgeons. Anecdotal evidence from oncology services suggests large variation in wait times and pathways.Objective: To examine time intervals and pathways between the detection of a breast abnormality and formal assessment by medical or radiation oncology for adjuvant treatment.Methods: Retrospective chart review of all patients with a new diagnosis of breast cancer first seen at the Fraser Valley Cancer Center in 2002, linked with demographic and other registry data. Data collected included type, location, date of investigations, surgical procedures, diagnosis, treatment and stage. Exclusion criteria were patients initially diagnosed with metastatic breast cancer, patients with recurrent breast cancer, male breast cancer patients, patients diagnosed or previously treated outside BC. Microsoft Access and SAS 9.2 were used to enter and analyse data.Results: From a total of 513 women diagnosed in 2002 with invasive breast cancer, 422 women (82%), without metastases (age 30 to 97 yrs, median 59 yrs), presented with abnormal screen (45%), breast lump (47%) or other findings. These women had up to 7 different radiological breast investigations and up to 5 surgical interventions. About 5% had 5 or more breast investigations. Median time (days) from presentation to first surgery was 41 days and varied by location of first investigation. Time to surgery was highest among women who presented with abnormal screening mammogram (median 49 days). Median time from first surgery consultation to first surgery was lowest for women presenting with breast lumps (15 days).Conclusions: These data indicate wait times beyond national and international targets and identified wide variability and some inefficient, redundant or unnecessary steps. Recognition and analysis of abnormal pathways will guide changes in breast health service delivery. Citation Information: Cancer Res 2009;69(24 Suppl):Abstract nr 3083.
Is the cholera pandemic waning.
Authors: J N Davies
Journal: BMJ (1976)

reported to arrest haemorrhage from oesophageal varices in a proportion of cases for periods ranging from hours to months,' --6 but haemorrhage recurred in some patients when the cannula was removed.2 46The effectiveness of thoracic duct cannulation for bleeding oesophageal varices is still a controversial, matter.In spite of this, I think that the policy that should be adopted is to perform cannulation of the thoracic duct in patients not fit for major emergency operation.If this minor palliative procedure succeeds in preventing further bleeding the patient can be better prepared for a portacaval shunt operation that can be conducted a few days after his general condition has improved.
John Desmond Taylor
Authors: G. Koffman
Journal: BMJ (2014)

John Desmond Taylor studied medicine at Cambridge, where he rowed for Selwyn College, then at Guy’s, where he remembered attending the wards as a child with his father, a distinguished Guy’s-trained cardiac surgeon. This sparked his fascination for surgery, reinforced by a surgical house job with Ian McColl (later Lord McColl of Dulwich) and a cardiothoracic senior house officer post, also at Guy’s. John completed his training …
A NOTE ON THE PRODUCTION OF DIARRHOEA BY THE BACILLUS PRODIGIOSUS
Authors: L. C. Parkes
Journal: BMJ (1905)

Ito be expected in the fourth week of the disease.For this reason his diet was not improved, and he was sedulously watched.A sharp but short relapse occurred, at the end of which the urine passed increased from 30 to 40 cz. to 8o, g9, and even I10 oz , and an uninterrupted convalescence took place.In no case in which polyuria was noted have I known perforation to occur, and in no case has haemorrbage of any moment ever occurred after polyaria has been established, and, furthermore, the oceurrence of relapse is of the most extreme rarity when polyuria has once begun.
Amifostine does not prevent activation of TGFβ1 but induces smad 7 activation in megakaryocytes irradiated in vivo
Authors: Helena R.C. Segreto, Alice T. Ferreira, Edna T. Kimura, Marcello Franco, Mizue I. Egami, Maria Regina R. Silva, Roberto A. Segreto
Journal: American Journal of Hematology (2002)

Abstract Experiments were undertaken to assess the role of amifostine in the activation of latent TGFβ1 and in the smad proteins cascade (smad 2/3, smad4, smad7), focusing on megakaryocytes, in the bone marrow irradiated in vivo. Non‐irradiated megakaryocytes were negative for active TGFβ1. Immunopositivity to active TGFβ1 was detected in megakaryocytes 10 days after irradiation in amifostine‐ treated and untreated marrows. Smad 2/3 and smad 4 were strongly positive in the nucleus of megakaryocytes 10 days after irradiation. At the same time, a predominant hypocellular bone marrow with foci of hematopoiesis was observed with few megakaryocytes. An increase in the number of reticulin fibers was also seen. In amifostine‐treated marrows, smad 2/3 and smad4 were not detected in the nucleus but were positive in the cytoplasm of megakaryocytes 10 days after irradiation. Coincidentally, bone marrows were cellular with megakaryocytes. Smad7 immunoexpression was detected in the cytoplasm of megakaryocytes in the non‐irradiated, amifostine‐treated and in the irradiated, amifostine‐treated marrows. Data indicate that amifostine does not prevent latent TGFβ1 activation in irradiated megakaryocytes. While TGFβ1 signal transduction occurs in megakaryocytes in untreated bone marrows, it is inhibited in megakaryocytes in amifostine‐treated marrows due to the induction of smad 7 activation. This is the first report showing smad 7 activation by amifostine. Our results also suggest a role for TGFβ1 as an inhibitor of megakaryocytes in vivo. Am. J. Hematol. 71:143–151, 2002. © 2002 Wiley‐Liss, Inc.
Knee Replacement Underused, Says Panel
Authors: Brian Vastag
Journal: JAMA (2004)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Fresh Skin &amp; Old Scars
Authors: Joseph D. Freeman
Journal: Annals of Internal Medicine (2007)

Ad Libitum18 September 2007Fresh Skin & Old ScarsJoseph D. FreemanJoseph D. FreemanFrom the University of Washington School of Medicine, Seattle, WA 98105.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-147-6-200709180-00009 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail A small group of medical studentswho had seen too little a part of life,sat facinga homeless teenager who had seen too much:Hit when she shouldn't have,touched where she shouldn't have.She had cried for help when she was younger:an A student turned Fa friendly kid who started to pick playground fights.Yelled as loud as a little girl could,it's just that no one chose to listen.Or perhaps, no one was strong enough to hear.tattoos on her knuckles silently ... Author, Article, and Disclosure InformationAffiliations: From the University of Washington School of Medicine, Seattle, WA 98105.Current Author Address: Joseph D. Freeman, 4625 Yarrow Point Road, Bellevue, WA 98004. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 18 September 2007Volume 147, Issue 6Page: 399KeywordsAdolescentsScars ePublished: 18 September 2007 Issue Published: 18 September 2007 Copyright & PermissionsCopyright © 2007 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Using Geographic Information Systems for Exposure Assessment in Environmental Epidemiology Studies
Authors: John R. Nuckols, Mary H. Ward, Lars Jarup
Journal: Environmental Health Perspectives (2004)

Geographic information systems (GIS) are being used with increasing frequency in environmental epidemiology studies. Reported applications include locating the study population by geocoding addresses (assigning mapping coordinates), using proximity analysis of contaminant source as a surrogate for exposure, and integrating environmental monitoring data into the analysis of the health outcomes. Although most of these studies have been ecologic in design, some have used GIS in estimating environmental levels of a contaminant at the individual level and to design exposure metrics for use in epidemiologic studies. In this article we discuss fundamentals of three scientific disciplines instrumental to using GIS in exposure assessment for epidemiologic studies: geospatial science, environmental science, and epidemiology. We also explore how a GIS can be used to accomplish several steps in the exposure assessment process. These steps include defining the study population, identifying source and potential routes of exposure, estimating environmental levels of target contaminants, and estimating personal exposures. We present and discuss examples for the first three steps. We discuss potential use of GIS and global positioning systems (GPS) in the last step. On the basis of our findings, we conclude that the use of GIS in exposure assessment for environmental epidemiology studies is not only feasible but can enhance the understanding of the association between contaminants in our environment and disease.
Rhinovirus 16–induced IFN-α and IFN-β are deficient in bronchoalveolar lavage cells in asthmatic patients
Authors: Annemarie Sykes, Michael R. Edwards, Jonathan Macintyre, Ajerico del Rosario, Eteri Bakhsoliani, Maria-Belen Trujillo-Torralbo, Onn Min Kon, Patrick Mallia, Mark McHale, Sebastian L. Johnston
Journal: Journal of Allergy and Clinical Immunology (2012)
Concerted peptide trimming by human ERAP1 and ERAP2 aminopeptidase complexes in the endoplasmic reticulum
Authors: Loredana Saveanu, Oliver Carroll, Vivian Lindo, Margarita Del Val, Daniel Lopez, Yves Lepelletier, Fiona Greer, Lutz Schomburg, Doriana Fruci, Gabriele Niedermann, Peter M van Endert
Journal: Nature Immunology (2005)
Neuropathy in Acute Intermittent Porphyria.
Authors: Willibald Nagler
Journal: Annals of Internal Medicine (1972)

Meeting Abstracts1 May 1972Neuropathy in Acute Intermittent Porphyria.Willibald Nagler, M.D., F.A.C.P.Willibald Nagler, M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-76-5-878_4 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo define the nature of motor paralysis after an acute attack of intermittent porphyria, electrodiagnostic studies were performed in five patients. Fortnightly electromyographic studies, nerve-conduction velocity measurements, and biochemical tests were carried out from the acute onset of the paralysis to recovery. Nerve and muscle biopsies were performed in two patients. Ten to 14 days after the onset of the extensive paralysis an abundance of fibrillation potentials was found by needle electromyography. The appearance of polyphasic, large-amplitude, and long-duration potentials after 6 to 8 weeks was characteristic for neuronal regeneration. On each electromyographic examination, the coaxial needle electrode was inserted... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: New York, N.Y. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byNeurotoxic aspects of porphyrinopathies: Lead and succinylacetone 1 May 1972Volume 76, Issue 5Page: 878-878KeywordsAtrial fibrillationElectromyographyMuscle biopsiesNervesNeuropathyParalysisPorphyriaRegenerative medicine Issue Published: 1 May 1972 PDF downloadLoading ...
Houseofficer Proficiency in Urinalysis and Sputum Gram Stains
Authors: GARY GARBER
Journal: Annals of Internal Medicine (1984)

Letters and Corrections1 July 1984Houseofficer Proficiency in Urinalysis and Sputum Gram StainsGARY GARBER, M.D., MICHAEL FIORE, M.D., DAN L. GOLDENBERG, M.D.GARY GARBER, M.D.Search for more papers by this author, MICHAEL FIORE, M.D.Search for more papers by this author, DAN L. GOLDENBERG, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-101-1-139_1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: Proficiency in basic laboratory techniques and their interpretation is a skill that most physicians are expected to learn during residency training. No studies have examined the proficiency of medical housestaff in doing and interpreting routine laboratory procedures, although interpretation of commercial (Chem-strip; Ames Division, Miles Laboratories, Elkhart, Indiana) urinalyses as done by laboratory technicians has been compared with that of nurses, physicians, and medical students (1-3). Therefore, a pilot study to assess prospectively the proficiency of medical houseofficers at the Boston City Hospital in doing and interpreting routine tests was carried out during May 1983. The results...References1. Uroscopy by nought and crosses. Lancet. 1962;1:413. Google Scholar2. SIMPSONTHOMPSON ED. Routine urinalysis. Lancet. 1977;2:36. Google Scholar3. SHEPHARDPENBERTHYFRASER MLC. Urinalysis in an Australian teaching hospital. Med J Aust. 1982;1:300. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Boston University School of Medicine Boston City Hospital Boston, MA 02118 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 July 1984Volume 101, Issue 1Page: 139-139KeywordsPilot studiesResearch laboratoriesResidencySputumTechnicians Issue Published: 1 July 1984 PDF DownloadLoading ...
Stillbirth rates in the area around Windscale, 1949-81.
Authors: T Sorahan, J A Waterhouse
Journal: BMJ (1984)

much experimental work as stating ". . . it may still be premature to say with conviction that radiation as a cause of non-disjunction in- creases the frequency of 21-trisomy.However, it seems logical to avoid unnecessary exposure to mutagens that might add to the genetic burden of humans."
Does endoscopic treatment for early oesophageal cancers give equivalent oncological outcomes as compared with oesophagectomy? Best evidence topic (BET)
Authors: Athanasios Fovos, Omar Jarral, Nikos Panagiotopoulos, Thrasyvoulos Podas, Sameh Mikhail, Emmanouil Zacharakis
Journal: International Journal of Surgery (2012)
Isohemagglutinins of Graft Origin after ABO-Unmatched Liver Transplantation
Authors: Glenn Ramsey, Jacob Nusbacher, Thomas E. Starzl, Gwenn D. Lindsay
Journal: New England Journal of Medicine (1984)

THE increasing success of liver transplantation in recent years has provided an experimental model to study and document the hepatic synthesis of many plasma proteins.1 2 3 4 5 The normal hepatobiliary tract has not been regarded as a major source of antibody,6 , 7 aside from the enteric IgA secreted from plasma into the biliary tree.8 Liver transplantation affords the opportunity to study the production of antibody to red cells. Recipient ABO incompatibility to the donor (a mismatched transplant, e.g., a group A liver transplanted into a group B recipient), although not absolutely contraindicated in liver transplantation, is avoided when possible. However, ABO-unmatched transplants (defined . . .
Pancreatobiliary maljunction in Western adults
Authors: J. García-Cano
Journal: Endoscopy (2009)

I read with interest the recent report by Bechtler et al. [1] about a choledochal cyst type I A with drainage through the ventral duct in a patient with pancreas divisum. It is true that most biliary cysts are secondary to anomalous pancreatobiliary junction, also called pancreatobiliary maljunction (PBMJ). This abnormality (an extramural junction of the pancreatic and biliary ducts in the duodenum, apparently beyond the scope of intramural sphincter function), has been extensively reported in Eastern people [2], but, as we have stated previously [3], PBMJ is not only an Eastern disease and this diagnosis is increasingly being made in other populations [4]. It is important, as Bechtler et al. [1] remark, to give attention to the distal part of the common bile duct as it can show side branches like a pancreatic duct ([Fig. 1], [2]).