tbuckley/cabot-search huggingface dataset:
Analysis of the VCX3A, VCX2 and VCX3B genes shows that VCX3A gene deletion is not sufficient to result in mental retardation in X-linked ichthyosis
Authors: S.A. Cuevas-Covarrubias, L.M. González-Huerta
Journal: British Journal of Dermatology (2007)

Background X-linked ichthyosis (XLI), an inborn error of metabolism, is due to steroid sulphatase (STS) deficiency. Most patients with XLI harbour complete deletion of the STS gene and flanking sequences. The presence of low copy number repeats on either side of the STS gene seems to have a major role in the high frequency of these deletions. Some patients with XLI with terminal deletions of Xp22.3 involving marker DXS1139 and the STS gene show mental retardation (MR); VCX3A is the only gene located on this critical region. Objectives To analyse the VCX3A, VCX, VCX2 and VCX3B genes in 80 unrelated Mexican patients with XLI with normal intelligence. Methods STS activity was measured in the leucocytes using 7-[3H]-dehydroepiandrosterone sulphate as a substrate. Amplification of the regions from telomeric DXS89 to centromeric DXS1134 including both extremes of the STS and the VCX3A, VCX, VCX2 and VCX3B genes was performed using polymerase chain reaction. Results No STS activity was detected in the patients with XLI (0·00 pmol mg−1 protein h−1). We observed two different deletion patterns: the first group included 62 patients with deletion of VCX3A and VCX genes. The second group included 18 patients with breakpoints at several regions on either side of the STS gene not including the VCX3A gene. Conclusions These data indicate that more complex mechanisms, apart from possible VCX3A gene participation, are occurring in the genesis of MR in XLI, at least in the sample of Mexican patients analysed.
Hybrid-Versus-Parental Strain Reaction. I. Comparative Mortality in Allogeneic and Parental Strain Male and Female Mice
Authors: Delta E. Uphoff
Journal: JNCI Journal of the National Cancer Institute (1975)

Lethally irradiated male and female hybrids, parental strains, and the third party strain A mice were inoculated with reciprocal hybrid marrow from donors of the same sex. A graft-versus-host reaction was produced against H-Y antigens of reciprocal hybrids. Although the late mortality in inbred strain males was generally greater than that of females, without further tests this difference was not automatically attributable to an X or a Y chromosome disparity. Hybrids did not recognize the qualitative difference in antigenicity of their reciprocals, but they were able to recognize the quantitatively greater antigenicity of their parental strains, and a hybrid-versus-parental strain reaction occurred. The graft-versus-host reaction in the third party strain A mice was significantly more severe than that produced by hybrid marrow in their reciprocal hybrid recipients, but significantly less severe than that produced in the parental strains. The relationship between antigenicity and responsiveness was such that the severity of the graft-versus-host reactions masked the maternal influences observed with other reciprocal hybrids.
<i>Yukon</i>
Authors: Jeanette M. Smith
Journal: JAMA (2015)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Pharmacological Treatment of Neuropsychiatric Symptoms of Dementia
Authors: Martin Steinberg, Constantine Lyketsos
Journal: JAMA (2005)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Abstract 2659: The MedImmune ADC platform: Building highly potent and specific cancer drugs
Authors: Robert E. Hollingsworth, Adeela Kamal, Philip W. Howard, John A. Hartley, David Tice, Changshou Gao, Nazzareno Dimasi, Haihong Zhong, Jay Harper, Zhan Xiao, Dorin Toader, Chris Martin, Herren Wu, Norman Greenberg, Bahija Jallal
Journal: Cancer Research (2014)

Abstract MedImmune has made a major commitment to developing antibody-drug conjugates for cancer. Our ADC initiative builds on our previous experience with this area and with other armed antibody technologies, which have generated several drugs currently undergoing clinical development. We have leveraged our expertise in antibody engineering to develop new antibody constructs for ADC development, including variants that facilitate site-specific conjugation of the payload to the antibody. This technology circumvents problems associated with random payload conjugation, resulting in a more homogeneous drug product as well as improving the stability and potency of the ADC. We have developed new, potent payloads, teaming up with Spirogen to apply their expertise in the pyrrolobenzodiazapine (PBD) dimer payload technology. The PBD payloads are versatile and potent, allowing use of multiple types of linkers and adjustment of potency to very high levels (picomolar IC50 range). The mechanism of action of the PBDs is different from other commonly used ADC payloads, inducing DNA damage that may evade DNA repair mechanisms and killing both bulk cancer cells and cancer stem cells. We have also developed other, novel ADC payloads. Our ADC target discovery approach permits rapid identification and validation of targets specifically suited for this technology. This includes the early generation and use of tool ADCs for target evaluation. We are applying this state-of-the-art ADC platform to advancing multiple projects as a major component of our oncology drug development strategy. Citation Format: Robert E. Hollingsworth, Adeela Kamal, Philip W. Howard, John A. Hartley, David Tice, Changshou Gao, Nazzareno Dimasi, Haihong Zhong, Jay Harper, Zhan Xiao, Dorin Toader, Chris Martin, Herren Wu, Norman Greenberg, Bahija Jallal. The MedImmune ADC platform: Building highly potent and specific cancer drugs. [abstract]. In: Proceedings of the 105th Annual Meeting of the American Association for Cancer Research; 2014 Apr 5-9; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2014;74(19 Suppl):Abstract nr 2659. doi:10.1158/1538-7445.AM2014-2659
Accuracy of β -D-glucan for the diagnosis of Pneumocystis jirovecii pneumonia: a meta-analysis
Authors: D.E. Karageorgopoulos, J.-M. Qu, I.P. Korbila, Y.-G. Zhu, V.A. Vasileiou, M.E. Falagas
Journal: Clinical Microbiology and Infection (2011)
Culture of Fear: Risk Taking and the Morality of Low Expectation, by Frank Furedi
Authors: S. W G Derbyshire
Journal: BMJ (1997)

Frank Furedi Cassell, £11.95, pp 184 ISBN 0 304 33751 X

I am not allowed to examine a female patient alone for fear that I may molest her or that she may falsely claim molestation. My colleagues seem not to understand why I get annoyed by this regulation. I try to explain that I do not want to live in a world where doctors are assumed rapists and patients assumed liars. Invariably, a patronising smile and murmurings about “navet” dispatch my vain efforts. Late 20th century society has become so obsessed with depravity, danger, and destruction that it is now common sense to assume only the worst will happen. Culture of Fear documents the origins of this outlook and its corrosive impact on human relations.



Fig 1 
Radioisotope scan of parathyroid adenoma in the left …
Abstract 10255: Cardiac Fibroblasts Regulate Adult Cardiomyocyte Excitation Contraction Coupling by Soluble Mediators in Co-Culture
Authors: James E Cartledge, Lucy A Clark, Micheal Ibrahim, Urszula Siedlecka, Manoraj Navaratnarajah, Magdi H Yacoub, Patrizia Camelliti, Cesare M Terracciano, Adrian H Chester
Journal: Circulation (2011)

Cardiac fibroblasts (CF) are essential constituents of the normal heart and important players in the pathogenesis of heart disease. Using a system which only allows paracrine communication, we test...
Abstract P192: Healthy Eating Index and Metabolically Healthy Obesity in U.S. Adolescents and Adults
Authors: Sarah M Camhi, E. W Evans, Laura L Hayman, Alice H Lichtenstein, Aviva Must
Journal: Circulation (2014)

Purpose: Studies of dietary intake between metabolically healthy obese (MHO) and metabolically abnormal obese (MAO) cardiometabolic profiles have been limited to macronutrient and micronutrient composition in postmenopausal women. Thus, the purpose of this study is to determine whether diet quality, measured by total and component Healthy Eating Index 2005 (HEI-2005), is different between MHO and MAO in a nationally representative sample. Methods: Data from two National Health and Nutrition Examination Surveys (2007-2008; 2010-2011) were used to identify 133 obese (≥85th BMI %tile) adolescents 12-18 years, and 1164 obese (≥30kg/m2) adults 19-85 years. Adolescents and adults were classified as MAO if they had ≥2 cardiometabolic risk factors (adults: blood pressure ≥130/85 mmHg; triglycerides ≥150 mg/dL, HDL-C men &lt;40, women &lt;50 mg/dL; glucose ≥100 mg/dL; or on relevant medications; adolescents: triglycerides ≥150 mg/dL; HDL-C &lt;40/50 mg/dL for boys/girls; blood pressure ≥90th %tile for age, gender, and height; glucose ≥100 mg/dL or on relevant medications), or MHO if they had &lt;2 cardiometabolic risk factors. HEI-2005 scores were calculated from in-person 24-hour recall. Age group (12-18 years n=133, 19-44 years n=491; 45-85 years n=673) general linear regression models were used to determine whether total and component HEI-2005 scores differed between MHO and MAO after controlling for age, race, gender, NHANES wave, BMI and moderate to vigorous physical activity. Results: MHO adolescents (n=45; 72%) had better quality diets as indicated by a higher total HEI-2005 score compared with MAO (MHO vs. MAO, mean ± SE; p-value for difference: 55.2 ± 1.2 vs. 47.8 ± 2.6; p=0.005), higher milk scores (5.2 ± 0.4 vs. 3.5 ± 0.7; p=0.03), and higher scores from calories from solid fats, alcohol beverages, and added sugars (SoFAAS) (15.5 ± 0.7 vs. 11.6 ± 1.0, p=0.007). The SoFAAS component score is reverse coded where a higher score indicates better adherence to diet recommendations (&lt;20%). Adults 19-44 years with MHO profiles (n=229, 46%) had higher HEI-2005 scores compared with MAO (54.0 ± 1.0 vs. 51.3 ± 0.8; p=0.008) and higher whole grain scores (0.9 ± 0.1 vs. 0.4 ± 0.07, p=0.003). No significant differences between MHO (n=127; 23%) vs. MAO in HEI-2005 scores or its component scores were observed in adults 45-85 years of age. Conclusion: MAO and MHO cardiometabolic profiles are characterized by differences in HEI-2005 total and component scores, though these differ by age group. Results suggest potential intervention targets which may improve cardiometabolic risk within obesity.
Assessment of Consumer Knowledge of New Sunscreen Labels
Authors: Betty Y. Kong, Sarah L. Sheu, Roopal V. Kundu
Journal: JAMA Dermatology (2015)

Assessment of Consumer Knowledge of New Sunscreen LabelsUV-A radiation is associated with accelerated skin aging, while UV-B exposure is associated with sunburns. 1Exposure to both types of radiation is a major risk factor for the development of skin cancer. 1 By protecting the skin from UV light, sunscreen protects against these negative sequelae of sun exposure. 2-4In 2011, the US Food and Drug Administration announced new regulations for sunscreen labels to emphasize the importance of protection against both UV-A and UV-B radiation, now known as broad-spectrum protection. 5,6In this survey study, we assessed consumer comprehension of sunscreen labels and knowledge of general sun protective behaviors.
Abstract 13243: Diminished Daily Fluctuation of Heart Rate Variability in Patients with Chronic Kidney Disease
Authors: Hisaki Makimoto, Katsuhito Fujiu, Kohei Shimizu, Eisuke Amiya, Kazuo Asada, Toshiya Kojima, Masao Daimon, Christian Meyer, Issei Komuro
Journal: Circulation (2014)

Introduction: Autonomic dysfunction is well known in patients with chronic kidney disease (CKD) and linked with cardiac death. In spite of a high incidence of morning death in CKD patients, circadian fluctuation in parasympathetic activation have not been studied in CKD. Hypothesis: We assessed the hypothesis that the cardiac autonomic circadian fluctuation is impaired in patients with CKD. Methods: The study population consisted of consecutive 101 patients (54 males, 70±10 years old) with CKD who underwent 24-hour Holter monitor. As a control group, 134 age and sex matched cases (66 males, 68±10 years old) without CKD who also underwent Holter monitor were recruited. Patients with diabetes orβ-blocker therapy were excluded. The high frequency component (HF), which reflected parasympathetic activity, and the low frequency to high frequency ratio (L/H ratio), which reflected, in part, sympathetic activity, were evaluated. To evaluate the contribution of CKD and other parameters to the cardiac autonomic fluctuation, the night (6PM-6AM) to day (6AM-6PM) ratio of HF and L/H ratio were analyzed utilizing a regression analysis. Results: The L/H ratio showed no significant difference during the night between the two groups, in contrast to the significant difference during the daytime. Patients with CKD showed significantly lower HF during the night as compared to control cases (P&lt;0.05), although the daytime HF was not significantly different between the groups (Figure). Multivariate regression analysis demonstrated that CKD was independently associated with a lower night-to-day ratio of the HF and a higher night-to-day ratio of the L/H ration, even with the adjustment of age and comorbid hypertension. Conclusions: Our findings suggest that cardiac autonomic fluctuation is impaired in CKD patients. Whether a deterioration of autonomic activation might explain the high incidence of morning death in CKD patients needs to be clarified in future studies.
Clinical efficacy of three common treatments in acute otitis externa in primary care: randomised controlled trial
Authors: Frank A M van Balen, W Martijn Smit, Nicolaas P A Zuithoff, Theo J M Verheij
Journal: BMJ (2003)

<h3>Abstract</h3> <b>Objective</b> To compare the clinical efficacy of ear drops containing acetic acid, corticosteroid and acetic acid, and steroid and antibiotic in acute otitis externa in primary care. <b>Design</b> Randomised controlled trial. <b>Setting</b> 79 general practices, Netherlands. <b>Participants</b> 213 adults with acute otitis externa. <b>Main outcome measures</b> Primary outcome: duration of symptoms (days) according to patient diaries. Secondary outcome: cure rate according to general practitioner completed questionnaires and recurrence of symptoms between days 21 and 42. <b>Results</b> Symptoms lasted for a median of 8.0 days (95% confidence interval 7.0 to 9.0) in the acetic acid group, 7.0 days (5.8 to 8.3) in the steroid and acetic acid group, and 6.0 days (5.1 to 6.9) in the steroid and antibiotic group. The overall cure rates at seven, 14, and 21 days were 38%, 68%, and 75%, respectively. Compared with the acetic acid group, significantly more patients were cured in the steroid and acetic acid group and steroid and antibiotic group at day 14 (odds ratio 2.4, 1.1 to 5.3, and 3.5, 1.6 to 7.7, respectively) and day 21 (5.3, 2.0 to 13.7, and 3.9, 1.7 to 9.1, respectively). Recurrence of symptoms between days 21 and 42 occurred in 29% (50/172) of patients and was seen significantly less in the steroid and acetic acid group (0.3, 0.1 to 0.7) and steroid and antibiotic group (0.4, 0.2 to 1.0) than in the acetic acid group. <b>Conclusions</b> Ear drops containing corticosteroids are more effective than acetic acid ear drops in the treatment of acute otitis externa in primary care. Steroid and acetic acid or steroid and antibiotic ear drops are equally effective.
RELIEF OF PAIN IN ACUTE MYOCARDIAL INFARCTION BY PROCAINE BLOCK OF THE SYMPATHETIC NERVE SUPPLY
Authors: C A FISH, E G GRANTHAM
Journal: Annals of Internal Medicine (1952)

Case Reports1 January 1952RELIEF OF PAIN IN ACUTE MYOCARDIAL INFARCTION BY PROCAINE BLOCK OF THE SYMPATHETIC NERVE SUPPLYCARLOS A. FISH, M.D., F.A.C.P., EVERETT G. GRANTHAM, M.D.CARLOS A. FISH, M.D., F.A.C.P.Search for more papers by this author, EVERETT G. GRANTHAM, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-36-1-172 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptMandl in 1925 was the first to use procaine block for the relief of cardiac pain. Swetlow2in 1926 introduced the use of alcohol for longer lasting relief by a chemical block. In America this procedure was perfected and popularized by White.3Alcohol blocks, sympathectomy and rhizotomy are accepted procedures in general use today for the relief of angina pectoris. We have been unable, however, to find in the literature any reference to the use of sympathetic block for the relief of the pain in acute myocardial infarction. The dramatic relief of pain in a patient with acute coronary occlusion...Bibliography1. Mandl F: Die Wirkung der paravertebral Injektion bei Angina pectoris, Arch. f. klin. Chir. 136: 495, 1925. Google Scholar2. Swetlow GI: Paravertebral alcohol block in cardiac pain, Am. Heart J. 1: 393, 1926. CrossrefGoogle Scholar3. White JC: Technique of paravertebral alcoholic injection methods and safeguards in its use in the treatment of angina pectoris, Surg., Gynec. and Obst. 71: 334, 1940. Google Scholar4. Heinbecker P: Heart pain, J. Thoracic Surg. 10: 44, 1940. CrossrefGoogle Scholar5. Lindgren I: Angina pectoris—a clinical study with special reference to neurosurgical treatment, Acta med. Scandinav., 1950 (Supplementum CCXLIII) (243). Google Scholar6. WhiteSmithwick JCRH: The autonomic nervous system, 1941, The Macmillan Company, New York. Google Scholar7. KatzJochim LNK: Observations on the innervation of the coronary vessels of the dog, Am. J. Physiol. 126: 395, 1939. CrossrefGoogle Scholar8. LericheFontaine RR: Quoted by Katz and Jochim.7 Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Louisville, Kentucky*Received for publication November 24, 1950.From the Departments of Internal Medicine and Surgery of the University of Louisville School of Medicine. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited bySYSTEMIC SHOCK OF CARDIOPULMONARY ORIGINDie Coronarerkrankungen. Coronarinsuffizienz, Angina pectoris und Herzinfarkt 1 January 1952Volume 36, Issue 1Page: 172-177KeywordsAcute myocardial infarctionAlcoholsAnginaNervesSurgerySympathectomy ePublished: 1 December 2008 Issue Published: 1 January 1952 PDF downloadLoading ...
The Fallacy of the Weighed Diet in the Treatment of Diabetes Mellitus
Authors: Helmuth Ulrich
Journal: Annals of Internal Medicine (1932)

Article1 June 1932The Fallacy of the Weighed Diet in the Treatment of Diabetes MellitusHELMUTH ULRICH, M.D., F.A.C.P.HELMUTH ULRICH, M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-5-12-1487 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe weighing of food is regarded as a great hardship by nearly all sufferers from diabetes mellitus, and I have become convinced that it is a burden they should not be required to bear. Hairsplitting figures concerning carbohydrate, protein and fat may make a fine appearance in a published article, but it is unlikely that they ever represent the actual conditions that obtain in the patient's kitchen. I am sure that the weighing of food is practiced much less than it is preached.Weighed diets are prescribed because they are supposed to make possible an accurate computation of the nutritive...References1 ATWATERBRYANT WOAP: The chemical composition of American food materials, U. S. Dept. of Agricult. Bull. No. 28, 1906. Google Scholar2 CHATFIELDMCLAUGHLIN CLI: Proximate composition of fresh fruits, U. S. Dept. of Agricult. Circ. No. 50 (Dec.) 1928. Google Scholar3 JOSLIN EP: The treatment of diabetes mellitus, third edition, p. 737; 1923, Lea, Febiger & Co., Philadelphia and New York. Google Scholar4 CAMPBELLPORTER WRMT: A guide for diabetics, 1926, Williams and Wilkins Co., Baltimore. Google Scholar5 HUDDLESON MP: Food for the diabetic, 1924, The Macmillan Co., New York. Google Scholar6 SANSUM WD: The treatment of diabetes mellitus with higher carbohydrate diets, 1929, Harper and Bros., New York. Google Scholar7 NEWBURGHMARSH LHPL: The use of a high fat diet in the treatment of diabetes mellitus, Arch. Int. Med., 1920, xxvi, 647. CrossrefGoogle Scholar8 RABINOWITCH IM: Experiences with a high carbohydrate-low calorie diet for the treatment of diabetes mellitus, Canad. Med. Assoc. Jr., 1930, xxiii, 489. Google Scholar9 ALLEN FM: Methods and results of diabetic treatment, New Eng. Med. Jr., 1930, cciii, 1133. CrossrefGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Boston, Massachusetts*From the Evans Memorial for Clinical Research and Preventive Medicine, Boston University School of Medicine, and The Massachusetts Memorial Hospitals, Boston.†Received for publication, October 20, 1931. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 June 1932Volume 5, Issue 12Page: 1487-1491KeywordsCarbohydratesDiabetes mellitusDietFatsFoodHospital medicinePreventive medicineProteins ePublished: 1 December 2008 Issue Published: 1 June 1932 PDF downloadLoading ...