Ibuprofen-Related Hypoglycemia in a Patient Receiving Sulfonylurea
Authors: Hirohito Sone, Akimitsu Takahashi, Nobuhiro Yamada
Journal: Annals of Internal Medicine (2001)

Letters20 February 2001Ibuprofen-Related Hypoglycemia in a Patient Receiving SulfonylureaHirohito Sone, MD, PhD, Akimitsu Takahashi, MD, and Nobuhiro Yamada, MD, PhDHirohito Sone, MD, PhDUniversity of Tsukuba; 305-8575 Tsukuba Ibaraki, Japan (Sone, Takahashi, Yamada), Akimitsu Takahashi, MDUniversity of Tsukuba; 305-8575 Tsukuba Ibaraki, Japan (Sone, Takahashi, Yamada), and Nobuhiro Yamada, MD, PhDUniversity of Tsukuba; 305-8575 Tsukuba Ibaraki, Japan (Sone, Takahashi, Yamada)Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-134-4-200102200-00027 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:Several agents, including aspirin, potentiate the effects of sulfonylureas and cause hypoglycemia (1). We describe a case of severe hypoglycemia induced by ibuprofen in a diabetic patient treated with a sulfonylurea.A 72-year-old man with a 20-year history of type 2 diabetes mellitus was receiving 2.5 mg of glibenclamide per day. His glycemic control had been stable, and he had not experienced any hypoglycemic episodes for several years. He developed a sore throat and arthralgia and took 150 mg of ibuprofen. Half an hour later, he developed severe nausea, sweating, and palpitations that were immediately relieved after ...References1. Davis SN, Granner DK. Insulin, oral hypoglycemic agents, and the pharmacology of the endocrine pancreas.. In: Hardman JG, Limbird LE, eds. Goodman and Gilman's Pharmacological Basis of Therapeutics. 9th ed. New York: McGraw-Hill; 1996:1487-518. Google Scholar2. Kubacka RT, Antal EJ, Juhl RP, Welshman IR. Effects of aspirin and ibuprofen on the pharmacokinetics and pharmacodynamics of glyburide in healthy subjects. Ann Pharmacother. 1996;30:20-6. [PMID: 0008773160] CrossrefMedlineGoogle Scholar3. Shah SJ, Bhandarkar SD, Satoskar RS. Drug interaction between chlorpropamide and non-steroidal anti-inflammatory drugs, ibuprofen and phenylbutazone. Int J Clin Pharmacol Ther Toxicol. 1984;22:470-2. [PMID: 0006500764] MedlineGoogle Scholar Author, Article, and Disclosure InformationAuthors: Hirohito Sone, MD, PhD; Akimitsu Takahashi, MD; Nobuhiro Yamada, MD, PhDAffiliations: University of Tsukuba; 305-8575 Tsukuba Ibaraki, Japan (Sone, Takahashi, Yamada) PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byCommon inpatient hypoglycemia phenotypes identified from an automated electronic health record–based prediction modelZafirlukast promotes insulin secretion by increasing calcium influx through L‐type calcium channelsTargeting inflammation using celecoxib with glimepiride in the treatment of obese type 2 diabetic Egyptian patientsIbuprofenSulfonylureasTherapie nozizeptiver Schmerzen bei Patienten mit Diabetes mellitusAnalgetika beim geriatrischen PatientenI Prostanoid Receptor–Mediated Inflammatory Pathway Promotes Hepatic Gluconeogenesis Through Activation of PKA and Inhibition of AKTIdentification of Drug-Induced Myocardial Infarction-Related Protein Targets through the Prediction of Drug–Target Interactions and Analysis of Biological ProcessesOutcomes of Community-Dwelling Adults without Diabetes Mellitus Who Require Ambulance Services for HypoglycemiaDrug-Induced HypoglycaemiaPolypharmazie und SchmerztherapieNON-STEROIDAL ANTI-INFLAMMATORY DRUGS (NSAIDs)INSULINS AND OTHER HYPOGLYCEMIC DRUGSSelective COX2 inhibition improves whole body and muscular insulin resistance in fructose-fed ratsNon-steroidal anti-inflammatory drugs increase insulin release from beta cells by inhibiting ATP-sensitive potassium channelsPrescribing to older ED patientsCyclooxygenase-2 (PTGS2) inhibitors augment the rate of hexose transport in L6 myotubes in an insulin- and AMPKα-independent mannerIbuprofenPolypharmacy and Possible Drug-Drug Interactions Among Diabetic Patients Receiving Home Health Care ServicesAnti-inflammatory and antipyretic analgesics and drugs used in goutIbuprofen 20 February 2001Volume 134, Issue 4Page: 344KeywordsAspirinBloodGlucoseHypoglycemiaHypoglycemicsIbuprofenPharmacokineticsPharyngitisRisk managementType 2 diabetes ePublished: 20 February 2001 Issue Published: 20 February 2001 Copyright & PermissionsCopyright © 2001 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...