GLUCOSE AND CORTISONE-GLUCOSE TOLERANCE IN NORMAL AND "PREDIABETIC" HUMANS
Authors: T H LAMBERT, R B JOHNSON, G R PAUL
Journal: Annals of Internal Medicine (1961)

Article1 May 1961GLUCOSE AND CORTISONE-GLUCOSE TOLERANCE IN NORMAL AND "PREDIABETIC" HUMANSTHOMAS H. LAMBERT, M.D., F.A.C.P., ROY B. JOHNSON, M.A., GEOFFREY R. PAUL, M.D.THOMAS H. LAMBERT, M.D., F.A.C.P.Search for more papers by this author, ROY B. JOHNSON, M.A.Search for more papers by this author, GEOFFREY R. PAUL, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-54-5-916 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptDetection of the potential diabetic is a principal objective of clinicians and many investigators. The classical work of Fajans and Conn1-4 and the investigations of West5-6 have focused attention on the use of cortisone in diagnosis and prediction of diabetes mellitus.The purpose of the present study was to investigate and to evaluate both glucose tolerance and cortisone-glucose tolerance in otherwise normal individuals and in subjects with a hereditary background for diabetes.SUBJECTS AND PROCEDURESThree hundred active subjects including controls, diabetics, and relatives of diabetics were studied. The diabetic relatives were blood-related kin of known diabetics and were not...Bibliography1. Conn JW: ACTH diabetes in man. The end-organ response versus the adrenocortical response. J. Clin. Endocr. 10: 825, 1950. Google Scholar2. FajansConn SSJW: An approach to the prediction of diabetes mellitus by modification of the glucose tolerance test with cortisone. Diabetes 3: 296, 1954. CrossrefMedlineGoogle Scholar3. FajansConn SSJW: Further studies on a test for the "prediction" of diabetes mellitus. Clin. Res. Proc. 3: 122, 1955. Google Scholar4. Conn JW: The prediabetic state in man: definition, interpretation and implications. Diabetes 7: 347, 1958. CrossrefMedlineGoogle Scholar5. West KW: Comparison of hyperglycemic effects of glucocorticoids in human beings: the effect of heredity on responses to glucocorticoids. Diabetes 6: 168, 1957. CrossrefMedlineGoogle Scholar6. West KW: Personal communication, 1960. Google Scholar7. MoyerWomack JHCR: Glucose tolerance: 1. A comparison of 4 types of diagnostic tests in 103 control subjects and 26 patients with diabetes. Amer. J. Med. Sci. 219: 161, 1950. CrossrefMedlineGoogle Scholar8. MosenthalBarry HOE: Criteria for and interpretation of normal glucose tolerance tests. Ann. Intern. Med. 33: 1175, 1950. LinkGoogle Scholar9. Hoet JP: Carbohydrate metabolism during pregnancy. Diabetes 3: 1, 1954. CrossrefMedlineGoogle Scholar10. German JL: The glucose tolerance test after cortisone administration in obese and non-obese men. Diabetes 7: 261, 1958. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: La Jolla, California*Received for publication October 19, 1960.From the Scripps Clinic and Research Foundation, La Jolla, Calif.Read in part before The American College of Physicians' Southern California Regional Meeting, Coronado, Calif., February 6, 1960; and before the Section on Internal Medicine at the 35th Anniversary Congress of the Pan American Medical Association, Mexico City, May 5, 1960.†Present address: University of Sydney, Sydney, Australia.Requests for reprints should be addressed to Thomas H. Lambert, M.D., Scripps Clinic and Research Foundation, 476 Prospect Street, La Jolla, Calif. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byPrednisolone enhances β-cell function independently of ambient glycemic levels in type II diabetesDiabetes in the Offspring of Conjugal Diabetic ParentsDie Wirkungen der Corticosteroide auf den KohlenhydratstoffwechselDie Diagnostik des DiabetesTriamcinolone-augmented glucose tolerance in offspring of diabetic couplesCarbohydrate metabolism in pregnancyThe oral glucose tolerance test: A study of the influence of age on the response to the standard oral 50 g glucose loadClinical and Chemical Diabetes in Offspring of Diabetic CouplesREFERENCESThe Study of Carbohydrate MetabolismThe Cortisone-Glucose Tolerance Test The Influence of Age on PerformanceTHOMAS POZEFSKY, M.D., JOEL L. COLKER, M.D., HAROLD M. LANGS, M.D., REUBIN ANDRES, M.D.Effects of Steroids on the PancreasAFTERNOON GLUCOSE TOLERANCE TESTING: A KEY TO THE PATHOGENESIS, EARLY DIAGNOSIS AND PROGNOSIS OF DIABETOGENIC HYPERINSULINISM 1 May 1961Volume 54, Issue 5Page: 916-923KeywordsDiabetes mellitusGenetic predispositionGlucoseGlucose tolerance ePublished: 1 December 2008 Issue Published: 1 May 1961 PDF downloadLoading ...