THE LONG-TERM USE OF THE ORAL DIURETIC 3-CHLORO-MERCURI-2-METHOXY-PROPYLUREA (NEOHYDRIN) IN AMBULATORY PATIENTS
Authors: J M EVANS, R A MASSUMI
Journal: Annals of Internal Medicine (1956)

Article1 January 1956THE LONG-TERM USE OF THE ORAL DIURETIC 3-CHLORO-MERCURI-2-METHOXY-PROPYLUREA (NEOHYDRIN) IN AMBULATORY PATIENTSJOHN M. EVANS, M.D., RASHID A. MASSUMI, M.D.JOHN M. EVANS, M.D.Search for more papers by this author, RASHID A. MASSUMI, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-44-1-124 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptSodium and water retention continues to be the core problem in the management of congestive heart failure. Current practices of diuretic therapy with mercury compounds have vastly improved the management of this problem. However, the necessity of using mercury by injection imposes the limitations of inconvenience, expense and limited acceptability by the patient. In addition, there is an appreciable incidence of side effects, varying in severity from local irritation to the rare death from hypersensitivity or cardiac arrhythmia.1-8The continuing search for a satisfactory oral dosage form recently resulted in the development of 3-chloro-mercuri-2-methoxy-propylurea, Neohydrin.†9This is a crystalline non-ionic...Bibliography1. DeGraffLehman ACRA: Acute toxicity of mercurial diuretics, J. A. M. A. 119: 998, 1942. CrossrefGoogle Scholar2. DeGraffNadler ACJE: Review of toxic manifestations of mercurial diuretics in man, J. A. M. A. 119: 1006, 1942. CrossrefGoogle Scholar3. BarkerLindbergThomas MHHAME: Sudden death and mercurial diuretics, J. A. M. A. 119: 1001, 1942. CrossrefGoogle Scholar4. BrownFriedfeldKissinModellSussman GLMWRM: Deaths immediately following intravenous administration of Mercupurin, J. A. M. A. 119: 1004, 1942. CrossrefGoogle Scholar5. Kaufman RE: Immediate fatalities after intravenous mercurial diuretics, Ann. Int. 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DonovanMaurielloLeevy FJDACM: Neohydrin: a new oral mercurial diuretic, Internat. Rec. Med. 166: 410, 1953. Google Scholar23. DohertyBeardSadik JEOWH: The management of congestive heart failure with an oral mercurial diuretic, Am. Pract. and Digest. Treat. 5: 749, 1954. MedlineGoogle Scholar24. Vogl A: Loc. cit., p. 125. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Washington, D. C.*Received for publication June 1, 1955.From The Department of Medicine, The George Washington University School of Medicine, Washington, D. C.†Supplied through the courtesy of the Lakeside Laboratories, Inc., Milwaukee, Wisconsin. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byTHE DEVELOPMENT OF THE NEPHROTIC SYNDROME DURING THE COURSE OF CONGESTIVE HEART FAILURE: CASE REPORT AND REVIEW OF THE LITERATURE*JOHN M. THAYER, M.D., F.A.C.P., WILLIAM J. GLECKLER, M.D., F.A.C.P., ROBERT O. HOLMES, M.D.Therapie der HerzinsuffizienzDiamox (acetazoleamide) as an oral diuretic in ambulatory cardiac patientsTHE ROLE OF MAINTENANCE MERCURIALS IN THE MANAGEMENT OF CHRONIC CONGESTIVE HEART FAILURETHE OUTPATIENT MANAGEMENT OF THE CARDIAC PATIENT WITH MERCURIAL DIURETICSDiuretic Drugs in Congestive Heart FailureABSTRACTS OF CARDIOLOGY 1 January 1956Volume 44, Issue 1Page: 124-132KeywordsArrhythmiaAscitesDiureticsEdemaGastroenterology and hepatologyHeart failureHygieneHypersensitivitySodiumUrea ePublished: 1 December 2008 Issue Published: 1 January 1956 PDF downloadLoading ...