tbuckley/cabot-search huggingface dataset:
Abstract P265: Association of Dietary Fatty Acid Intake with Serum High-density Lipoprotein Particle Concentration
Authors: Maryam Zaid, Katsuyuki Miura, Akira Fujiyoshi, Akira Okayama, Hideaki Nakagawa, Kiyomi Sakata, Shigeyuki Saito, Nagako Okuda, Katsushi Yoshita, Sohel Choudhury, Beatriz Rodriguez, Kamal Masaki, Bradley Willcox, Naoko Miyagawa, Jeremiah Stamler, Hirotsugu Ueshima
Journal: Circulation (2014)

Background: Studies have found that HDL particle (HDL-P) concentration is inversely associated with risk of CVD, independent of HDL cholesterol (HDL-C). Dietary factors (such as fatty acid intake) have been found to affect levels of HDL-C and influence risk of CVD. However, little is known about the associations of dietary fatty acid with serum HDL-P levels. Hypothesis: We hypothesized that dietary fatty acid associations with HDL-P are independent of HDL-C in men. Methods: Data were from 463 male participants in the 1996-98 cross-sectional INTERLIPID Study, ages 40-59 years, randomly selected from five populations; four in Japan (n=386) and one in Hawaii (n=77). Fatty acid intake was estimated from the mean of four in-depth 24-hour dietary recalls (% kcal per day). Individuals were excluded due to missing data on HDL-P or HDL-C and use of lipid lowering medication. Serum HDL-P was measured using nuclear magnetic resonance and HDL-C was measured using standard methods. Multiple linear regression models were used to assess the association between dietary fatty acid and each of the lipid measures. Results: In men, HDL-P and HDL-C were moderately correlated (r = 0.52, p&lt;0.001). In Model 1 (Table), adjusted for age, country, alcohol intake, BMI, diabetes, hypertension, smoking status, and physical activity, most dietary fatty acids were significantly (p&lt;0.05) associated with HDL-P and HDL-C levels. In Model 2, further adjusted for HDL-C, almost all fatty acids maintained a significant association with HDL-P. In contrast, most associations of fatty acids and HDL-C ceased to be significant after adjustment for HDL-P. Total SFA and omega-3 PUFA remained associated with HDL-C. Conclusion: HDL-P was significantly associated with fatty acid intake, independent of HDL-C. Associations of dietary fatty acid intake and HDL-C level were weaker and generally not independent of HDL-P in men.
Abstract 4057: Modulation of actin binding proteins by docosahexaenoic acid reduces cancer cell migration
Authors: Mehboob Ali, Alexander Long, Kathryn M. Heyob, Asha Srinivasan, Lynette K. Rogers
Journal: Cancer Research (2014)

Abstract Cancer is the leading cause of death worldwide and all age groups, including children, are at risk for cancer associated death. Disease progression and metastasis are major contributors to cancer-associated morbidity and mortality. Increased cell migration rate is characteristic of tumor progression and metastasis. Actin binding proteins regulate cytoskeletal remodeling at the leading edges of cancer cells, facilitate invasive organelle (invadopodia) formation, and promote higher migration rates. Docosahexaenoic acid (DHA), a poly unsaturated fatty acid, has been shown to inhibit the cancer cell metastatic phenotype. Here, we test the hypothesis that changes in actin binding proteins regulate cancer cell migration and that supplementing cells with DHA will prevent these changes. Non-cancer (MLE12) and cancer (A549, HCT116 and MCF7) cells were treated with 8-Br-cAMP and/or DHA. F-actin content was measured using confocal microscopy. Cell migration was estimated by wound assay and transwell apparatus. Actin binding proteins, profilin, cofilin, vimentin and gelsolin, were identified and quantified using confocal microscopy and western blot to evaluate wound edges and actin co- munoprecipitate, respectively. F-actin content and cell migration were increased by cAMP in association with changes in profilin, cofilin, vimentin and gelsolin levels. DHA treatment suppressed the increase in actin content and cell migration in cancer cells but not in non-cancer cells in association with altered levels of actin binding proteins. We postulate that DHA specifically inhibits cancer cell migration via alterations in actin binding proteins indicating a therapeutic potential against cancer cell metastasis. The changes in actin binding proteins could serve as biomarkers for cancer progression and as innovative therapeutic targets. Citation Format: Mehboob Ali, Alexander Long, Kathryn M. Heyob, Asha Srinivasan, Lynette K. Rogers. Modulation of actin binding proteins by docosahexaenoic acid reduces cancer cell migration. [abstract]. In: Proceedings of the 105th Annual Meeting of the American Association for Cancer Research; 2014 Apr 5-9; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2014;74(19 Suppl):Abstract nr 4057. doi:10.1158/1538-7445.AM2014-4057
Abstract 18895: Utility of Remote Monitoring Using a Mobile Phone in Patients with Heart Failure: the REMOTE-HF-1 Study
Authors: Marcus Stahlberg, Satish C Govind, Nicole M Orr, Aasha S Gopal, Justine S Lachmann, R Bhagirath, S S Ramesh, Lars H Lund, Frieder Braunschweig
Journal: Circulation (2014)

Objective: To investigate the clinical feasibility (technical feasibility and patient-/clinician adherence) of remote telemonitoring, using a mobile phone, in an international and diverse HF population. Methods: HF patients from five centers in the USA, India and Sweden were equipped with a blood pressure apparatus, digital weight scale and a mobile phone device with custom made software for remote telemonitoring (Vitalbeat®). Patients were asked to record and transmit daily information on body weight, blood pressure and pulse rate as well as symptoms and adherence to medical therapy for 90 days. The primary endpoint, for assessment of general feasibility was defined as % of days with a combination of successful data transmission from patients and data read by clinicians. Acceptable clinical feasibility was a priori set as ≥ 66% of days meeting the primary endpoint. A survey was used to assess patients’ opinions about the remote monitoring system. Data was analyzed according to Intention to treat. Results: 46 HF patients were included (India=20, USA=13, Sweden=13; 59±16yrs; 84% male; NYHA-class 2.4±0.8) and followed for a total of 4410 days. The primary endpoint occurred in 3178 days (77%) and 34/46 patients (74%) exceeded the cut-off ≥ 66% of days meeting endpoint criteria. In the majority of patients (n=28; 61 %) the primary endpoint was met ≥ 90% of the days, and in 6 patients (13%) 66-89% of the days.Twelve patients (26%) opted to drop out of the study prematurely or were hospitalized for HF related causes. Compared to patients with acceptable clinical feasibility (≥ 66%), patients with less than acceptable feasibility (&lt; 66%) were older (72±12 vs. 56±15 yrs, p=0.003) and more likely to be followed at a center in USA or Sweden (p=0.02 vs. Indian centers). The monitoring system was described as user friendly by 91 % of patients. Conclusion: This study shows that remote telemonitoring using a mobile phone is clinically feasible in an international and diverse heart failure population. However, monitoring was less feasible in elderly patients and depended on the geographic location. Further studies are warranted to assess whether clinical feasibility can improve with improved software/hardware design and/or patient selection.
The minimal important difference of the pulmonary functional status and dyspnea questionnaire – Modified version in patients with COPD
Authors: Eloisa Regueiro, Chris Burtin, Daniel Langer, Hans Van Remoortel, Paul Baten, Valéria Pires Di Lorenzo, Dirceu Costa, Wim Janssens, Marc Decramer, Rik Gosselink, Thierry Troosters
Journal: European Respiratory Journal (2011)

Background:  The modified version of the Pulmonary Functional Status and Dyspnea Questionnaire (PFSDQ-M) is commonly used in COPD to obtain information about their symptoms and functional status. It has been shown to be responsive to change following pulmonary rehabilitation. The minimal important difference (MID) of the PFSDQ has never been established.   Aim:  To establish the MID of PFSDQ-M using different approaches.   Methods:  416 patients with COPD (FEV1 42±15%pred) completed the PFSDQ-M before and after a 3-month pulmonary rehabilitation program (ΔCRDQ +16±12points, Δ6MWD +45±89m, both p≤0.001). The correlation between the ΔPFSDQ-M and the anchors ΔCRDQ and Δ6MWD was calculated. When r ≥ 0.3 linear regression analyses were performed to predict the MID from these anchors (i.e. establish the ΔPFSDQ corresponding with 10points ΔCRDQ, 2.5points ΔCRDQdys, 30m Δ6MWD). We also applied the distribution-based Cohen9s effect size technique to confirm the MID.   Results:  Anchor and distribution - based methods estimates are summarized in Table 1.   Conclusion:  The MID of the PFSDQ-M ranged from - 3 to -6 points in patients with moderate to very severe COPD. The estimate was similar with both statistical techniques.  ER is a fellow of CAPES 1445/10-3
Stimulation of pp60Src activity limits nitric oxide signaling through increases in asymmetric dimethylarginine
Authors: Stephen Black, Christine Gross, Saurabh Aggarwal, Ruslan Rafikov, John Catravas, Mary-Louise Meadows, Mary Shaw, Sanjiv Kumar
Journal: European Respiratory Journal (2014)

We have shown that a decrease in dimethylaminohydrolase type 2 (DDAH2) activity and an increase in asymmetric dimethylarginine (ADMA) results in nitric oxide synthase derived oxidative/nitrative stress and that this contributes to acute lung injury (ALI) in mice exposed to lipopolysaccharide (LPS). The mechanism by which DDAH2 is regulated is unknown and was the focus of this study. pp60Src is a member of the Src-family protein tyrosine kinases. In pulmonary arterial endothelial cells (PAEC) and the mouse lung, LPS increased ADMA-mediated NOS-derived superoxide and this correlated with an increase in pp60Src activation and DDAH2 inhibition. LPS also increased the interaction of pp60Src with DDAH2 resulting in increased DDAH2 tyrosine phosphorylation. In PAEC, the over-expression of a dominant negative mutant of pp60Src (K295MSrc) prevented the LPS dependent decrease in DDAH2 activity and the resulting increase in ADMA levels and attenuated the ability of LPS to stimulate NOS-derived superoxide and peroxynitrite generation. Further, the over-expression of a constitutively active pp60Src (Y527FSrc) either in PAEC or the mouse endothelium was sufficient to inhibit DDAH2 activity and increase ADMA levels. Y527FSrc over-expression also increased NOS-derived superoxide and peroxynitrite generation. Mutating the single tyrosine (Y) residue of DDAH II located at aa207 to phenylalanine (Y207FDDAH2) produced an enzyme that was resistant to pp60Src dependent inhibition. Together our data suggest that in ALI, the effects of LPS on DDAH/ADMA signaling and downstream NOS-derived oxidative stress are dependent on the pp60Src-mediated tyrosine phosphorylation of DDAH II at Y207.
Abstract P251: Weight Change is Associated With Risk of Cardiovascular Mortality Among Singapore Chinese
Authors: Woon-Puay Koh, Jian-min Yuan, An Pan
Journal: Circulation (2015)

Introduction: While epidemiologic studies have established overweight and obesity as risk factors of cardiovascular disease (CVD) mortality, findings on the relationship of change in body weight with CVD mortality are inconsistent. Hypothesis: We assessed the hypothesis that weight change was related to CVD mortality among middle-aged to elderly Chinese in Singapore. Methods: We used prospective data from the Singapore Chinese Health Study, a population-based cohort of 63,257 Chinese men and women aged 45-74 years at recruitment (1993-1998). After 5.7 [standard deviation (SD) 1.4] years, we conducted a follow-up interview (1999-2004) among 52,322 surviving subjects in the cohort. Body weight and height were self-reported among 42,328 participants at both baseline and follow-up interviews. Weight change was computed by percentage difference in weight at both assessments relative to weight at baseline, and categorized as moderate-to-large loss (≥10%), small loss (5.1 to 9.9%), stable (±5%), small gain (5.1-9.9%), and moderate-to-large gain (≥10%). Cox proportional hazards regression model was applied to estimate hazard ratio (HR) after controlling for age, gender, dialect group, dietary pattern, smoking status, alcohol consumption, physical activity, hours of sleep and history of diabetes and hypertension. Results: A total of 1,805 CVD deaths were identified during the follow-up until December 31, 2013 [follow-up duration of 11.5 (SD 2.9) years]. Compared to participants with stable weight, those with moderate-to-large weight loss had a 42% higher risk of CVD mortality (HR: 1.42; 95% CI: 1.25-1.61), while those with moderate-to-large weight gain had a 19% higher risk (HR: 1.19; 95% CI: 1.02-1.37). The HR (95% CI) for stroke mortality was 1.77 (1.44-2.18) for moderate-to-large weight loss, and 1.42 (1.12-1.80) for moderate-to-large weight gain. Conversely, for coronary heart diseases (CHD) mortality, only moderate-to-large weight loss was associated with an increased risk (HR: 1.24; 95% CI: 1.05-1.47). The associations were not different by gender or age-group. When stratified by BMI at baseline using 23 kg/m 2 as cutoff for overweight, moderate-to-large weight loss was associated with increased risks of CHD and stroke mortality in both BMI groups. In contrast, moderate-to-large weight gain was only associated with increased risk of stroke mortality but not with CHD mortality in both BMI groups. Conclusions: In conclusion, this study suggested that both moderate-to-large weight loss and weight gain significantly increased risk of CVD mortality among middle-aged to elderly Chinese. This study emphasizes the importance of maintaining stable body weight in middle-aged and elderly populations.
Nonequivalent nuclear location of immunoglobulin alleles in B lymphocytes
Authors: Jane A. Skok, Karen E. Brown, Veronique Azuara, Marie-Laure Caparros, Jonathan Baxter, Katalin Takacs, Niall Dillon, David Gray, Robert P. Perry, Matthias Merkenschlager, Amanda G. Fisher
Journal: Nature Immunology (2001)
Enhanced Rho-Kinase Activity in Circulating Neutrophils of Patients With Vasospastic Angina
Authors: Yoku Kikuchi, Satoshi Yasuda, Kentaro Aizawa, Ryuji Tsuburaya, Yoshitaka Ito, Morihiko Takeda, Masaharu Nakayama, Kenta Ito, Jun Takahashi, Hiroaki Shimokawa
Journal: Journal of the American College of Cardiology (2011)
Metagenomic systems biology and metabolic modeling of the human microbiome
Authors: Roie Levy, Elhanan Borenstein
Journal: Gut Microbes (2014)

The human microbiome is a key contributor to health and development. Yet little is known about the ecological forces that are at play in defining the composition of such host-associated communities. Metagenomics-based studies have uncovered clear patterns of community structure but are often incapable of distinguishing alternative structuring paradigms. In a recent study, we integrated metagenomic analysis with a systems biology approach, using a reverse ecology framework to model numerous human microbiota species and to infer metabolic interactions between species. Comparing predicted interactions with species composition data revealed that the assembly of the human microbiome is dominated at the community level by habitat filtering. Furthermore, we demonstrated that this habitat filtering cannot be accounted for by known host phenotypes or by the metabolic versatility of the various species. Here we provide a summary of our findings and offer a brief perspective on related studies and on future approaches utilizing this metagenomic systems biology framework.
PULMONARY ACTINOMYCOSIS DUE TO ACTINOMYCES GRAMINIS
Authors: John P. Lynch, Rebecca A. Holt
Journal: Annals of Internal Medicine (1945)

Case Reports1 July 1945PULMONARY ACTINOMYCOSIS DUE TO ACTINOMYCES GRAMINISJOHN P. LYNCH, M.D., REBECCA A. HOLT, M.A.JOHN P. LYNCH, M.D., REBECCA A. HOLT, M.A.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-23-1-91 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe term, actinomycosis, is now applied by Topley and Wilson8to two groups of diseases of man and animals in which Actinomyces-like organisms are encountered. In the first group, the proliferation of an anaerobic organism asActinomyces bovisgives the appearance of colonies which have a ray structure in pus or tissues and often are described as "sulphur granules" orDrusen. In the second group are included all aerobic filamentous branching organisms which form a felted mycelium without any radial arrangement and without granule formation. Two type species are:Actinomyces graminiswhich is non-acid-fast and forms no granules in tissues;...Bibliography1. BIGGART JH: Actinomycosis graminis, Bull. Johns Hopkins Hosp., 1934, liv, 165-173. Google Scholar2. BOLLINGER O: Ueber eine neue Pilzkrankheit beim Rinde, Centralbl. f. d. med. Wissensch., 1877, xv, 481. Google Scholar3. BOSTROEM E: Untersuchungen ueber die Aktinomykose des Menschen, Beitr. z. path. Anat. u. z. allg. Path., 1891, ix, 1. Google Scholar4. CUTLERGROSS ECRE: Actinomycosis of the lung and pleura, Am. Rev. Tuberc., 1940, xli, 358-367. Google Scholar5. HOLT RA: Unreported case. Google Scholar6. SCHNEIDERFINUCANE LVDL: Pulmonary actinomycosis complicated by pneumothorax treatment, Dis. Chest, 1941, vii, 229-235. CrossrefGoogle Scholar7. SMITH RT: Actinomycosis of liver and lungs, Am. Jr. Surg., 1943, lx, 438-442. CrossrefGoogle Scholar8. TOPLEYWILSON WWGS: The principles of bacteriology and immunity, 2nd Ed., 1936, Wm. Wood & Co., Baltimore, Chap. LIV, Actinomycosis, actinobacillosis, and related diseases, pp. 989-999. Google Scholar9. ZEITLINLICHENSTEIN HBW: Actinomycotic abscess of brain, Arch. Path., 1937, xxiii, 58-66. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Richmond, Virginia*Received for publication April 29, 1944.From the Department of Medicine, McGuire Clinic, St. Luke's Hospital, and the Department of Bacteriology and Parasitology, Medical College of Virginia, Richmond, Virginia. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byDie Pilzerkrankungen der LungeSpezieller TeilNocardiosisAerobic Actinomyces SepticemiaCardiac Actinomycosis 1 July 1945Volume 23, Issue 1Page: 91-99KeywordsActinomycesActinomycosisBacteriologyHospital medicineParasitology ePublished: 1 December 2008 Issue Published: 1 July 1945 PDF downloadLoading ...
PROGNOSIS IN TUBERCULOSIS
Authors: F. M. Pottenger
Journal: Annals of Internal Medicine (1937)

Article1 September 1937PROGNOSIS IN TUBERCULOSISF. M. POTTENGER, M.D., F.A.C.P.F. M. POTTENGER, M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-11-3-474 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptINTRODUCTORYWhen one considers the prognosis of tuberculosis in its widest implications he is obliged to extend his discussion to every phase of the tuberculosis problem and consider every factor which influences bacillary growth and activity or modifies individual resistance. The outcome of the disease is influenced by the virulence and numbers of infecting bacilli; the type of the disease and its severity; the constitutional peculiarities of the patient; his general reacting powers; his condition at the time when infection occurs; the character of the tissues which are involved; the nature of the lesion; the time when the diagnosis is... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Monrovia, California*Read at the St. Louis meeting of the American College of Physicians, April 20, 1937. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 September 1937Volume 11, Issue 3Page: 474-483KeywordsInfectious diseasesLesions ePublished: 1 December 2008 Issue Published: 1 September 1937 PDF downloadLoading ...
A European collaborative study of cyclophosphamide, bortezomib, and dexamethasone in upfront treatment of systemic AL amyloidosis
Authors: Giovanni Palladini, Sajitha Sachchithanantham, Paolo Milani, Julian Gillmore, Andrea Foli, Helen Lachmann, Marco Basset, Philip Hawkins, Giampaolo Merlini, Ashutosh D. Wechalekar
Journal: Blood (2015)
Impact of aspirin and statins on long‐term survival in patients hospitalized with acute myocardial infarction complicated by heart failure: an analysis of 1706 patients
Authors: Christian Lewinter, John M. Bland, Simon Crouch, John G.F. Cleland, Patrick Doherty, Martin M. LeWinter, Lars Køber, Alistair S. Hall, Christopher P. Gale
Journal: European Journal of Heart Failure (2013)
Increased serum levels of soluble receptors for tumor necrosis factor in cancer patients.
Authors: Dan Aderka, Hartmut Engelmann, Vered Hornik, Yehuda Skornick, Yoram Levo, David Wallach, Gil Kushtai
Journal: Cancer Research (1991)

Soluble forms of the two molecular species of the cell surface receptors for tumor necrosis factor (TNF) have been detected in normal urine. Using enzyme-linked immunosorbent assays for these soluble receptors, we determined their levels in the sera of 40 healthy subjects and 59 patients with solid tumors. The mean +/- SD concentrations of both the soluble type I (p55) and type II (p75) receptors were significantly higher in the cancer patients than in the healthy controls: 1.96 +/- 1.19 versus 0.79 +/- 0.19 ng/ml (P less than 0.001) and 6.43 +/- 4.8 versus 3.2 +/- 0.6 ng/ml (P less than 0.001), respectively. The incidence and the extent of the increase correlated with the staging of disease. Sera of the cancer patients had a marked inhibitory effect on the in vitro cytocidal activity of TNF. This inhibition was proportional to the content of soluble TNF receptors and could be fully abolished by the addition to the sera of specific antibodies against the receptors. Among the cancer patients, the incidence of increase in the concentrations of soluble TNF receptors (about 70%) greatly exceeded that of the serum carcinoembryonic antigen (about 26%), a commonly used cancer marker. The origin of the serum soluble TNF receptors in cancer patients and the physiological implications of their effect on TNF function remain to be elucidated.
Reducing the Risk for Transfusion-transmitted Cytomegalovirus Infection
Authors: Merlin H. Sayers, Kenneth C. Anderson, Lawrence T. Goodnough, Sanford R. Kurtz, Thomas A. Lane, Patricia Pisciotto, Leslie E. Silberstein
Journal: Annals of Internal Medicine (1992)

To define the groups of patients at risk for transfusion-transmitted cytomegalovirus infection and to define the methods to reduce this risk.English-language publications on transfusion medicine.Studies were selected that described cytomegalovirus infection in transfusion-dependent patients. Special attention was paid to reports that included observations about the prevalence and clinical manifestations of cytomegalovirus infection and recommendations for the prevention of infection.Some patients with impaired immune responses who have never been exposed to cytomegalovirus are at risk for transfusion-transmitted cytomegalovirus infection. This infection, which is associated with substantial morbidity and mortality, can be avoided by additional screening of blood donors or by special processing of components for transfusion.Transfusion products that are unlikely to transmit cytomegalovirus infection can be prepared by filtration to remove leukocytes or can be obtained by selecting donors who are seronegative for antibodies to cytomegalovirus. These products are indicated for certain groups of immunosuppressed patients, including pregnant women who are cytomegalovirus seronegative, premature infants of low birth weight who are born to cytomegalovirus-seronegative mothers, cytomegalovirus-seronegative recipients of allogeneic bone marrow transplants from cytomegalovirus-seronegative donors, and cytomegalovirus-seronegative patients with the acquired immunodeficiency syndrome (AIDS).