tbuckley/cabot-search huggingface dataset:
Phosphoinositide Metabolism and Hormone Action*
Authors: ROBERT V. FARESE
Journal: Endocrine Reviews (1983)

PHOSPHATIDYLINOSITOL (PI), polyphosphoinositides (PPI), and other phospholipids in the phosphatidate-inositide cycle comprise only approximately 10% of total cellular phospholipids, but their turnover and chemical properties enable the inositides and related phospholipids to serve as important intracellular mediators in hormone and neurotransmitter action. Awareness of the rapidity of PI turnover dates back nearly 30 years to the pioneering work of the Hokins (1–3), who first observed this “phospholipid effect” during secretagogue action in the pancreas. During the past decade, there has been a flurry of investigative effort to further characterize and understand the biological significance of PI turnover; as a result, many hormones and neurotransmitters have been found to influence PI metabolism, new mechanisms for increasing PI turnover have been elucidated, and new insights have been developed concerning the role of PI turnover in a number of biological responses. Although the role of PI metabolism in hormone and neurotransmitter action has been the subject of several recent reviews (4–9), the present review will contrast several of the more important mechanisms that underlie changes in inositide turnover, and focus on one mechanism that has recently come to light from studies of ACTH action.
Mitral Cerclage Annuloplasty, A Novel Transcatheter Treatment for Secondary Mitral Valve Regurgitation
Authors: June-Hong Kim, Ozgur Kocaturk, Cengizhan Ozturk, Anthony Z. Faranesh, Merdim Sonmez, Smita Sampath, Christina E. Saikus, Ann H. Kim, Venkatesh K. Raman, J. Andrew Derbyshire, William H. Schenke, Victor J. Wright, Colin Berry, Elliot R. McVeigh, Robert J. Lederman
Journal: Journal of the American College of Cardiology (2009)
Primary Kaposi's Sarcoma of the Head and Neck
Authors: Douglas R. Gnepp, Wayne Chandler, Vincent Hyams
Journal: Annals of Internal Medicine (1984)

Kaposi's sarcoma is a cutaneous neoplasm commonly arising in the extremities, and rarely in the mucosa or skin of the head and neck. We discuss nine cases of Kaposi's sarcoma arising in the head and neck region, retrieved from the files of the Armed Forces Institute of Pathology, together with 74 cases from the literature. The commonest mucosal locations include the conjunctiva, palate, tongue, tonsils, and gums; common cutaneous sites are the eyelids, nose, ears, and face. Prognosis, sex distribution, and susceptible population groups for the head and neck tumor are similar to those for the commoner peripheral cutaneous form. Seventy percent of patients were 50 years or older; 15% of tumors occurred in children under 16 years. Children under 16 years were more likely to have initial head and neck involvement. In our series, 7 of 11 tumors in children initially involved the conjunctiva or skin of the eyelid. Recently the incidence of Kaposi's sarcoma has been increasing in patients with acquired immunodeficiency syndrome. The age of incidence for this group is lower; more tumors occur on the upper body, skin, and mucosal surfaces of the head and neck; and the prognosis is poorer than in traditional cases of Kaposi's sarcoma.
Bromocriptine and Hallucinations
Authors: PATRICIA L. HARRIS
Journal: Annals of Internal Medicine (1984)

Letters and Corrections1 July 1984Bromocriptine and HallucinationsPATRICIA L. HARRIS, PHARM. D.PATRICIA L. HARRIS, PHARM. D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-101-1-149_1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: Vance and associates (1) state in their review on bromocriptine, "Hallucinations have been associated with bromocriptine treatment in patients with Parkinson's disease but are not seen in patients receiving it for endocrine indications." Although the vast majority of hallucinations occur in patients receiving bromocriptine in high doses for Parkinson's disease, several cases have been reported recently in which bromocriptine induced hallucinations in patients receiving it for endocrine indications.Parkes (2) has stated that neuropsychiatric symptoms (including hallucinations) occur in 1% to 2% of patients with hormonal disorders who are treated with bromocriptine, usually in a dosage range...References1. VANCEEVANSTHORNER MWM. Bromocriptine. Ann Intern Med. 1984;100:78-91. LinkGoogle Scholar2. PARKES D. Bromocriptine. N Engl J Med. 1979;301:873-8. CrossrefMedlineGoogle Scholar3. EINARSONTURCHET TE. Psychotic reaction to low-dose bromocriptine. Clin Pharm. 1983;2:273-4. MedlineGoogle Scholar4. EINARSONTURCHET TE. Follow-up on bromocriptine-induced psychosis [Letter]. Clin Pharm. 1983;2:512. MedlineGoogle Scholar5. FRYEPARISERKIMO'SHAUGHNESSY PSMR. Bromocriptine associated with symptom exacerbation during neuroleptic treatment of schizoaffective schizophrenia. J Clin Psychiatry. 1982;43:252-3. MedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: National Institutes of Health Bethesda, MD 20205 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byHallucinations: diagnosis, neurobiology and clinical management 1 July 1984Volume 101, Issue 1Page: 149-149KeywordsHallucinationsParkinson diseasePatients Issue Published: 1 July 1984 PDF downloadLoading ...
Methotrexate and Inflammatory Bowel Disease
Authors: Samuel Meyers
Journal: Annals of Internal Medicine (1989)

Letters and Corrections15 May 1989Methotrexate and Inflammatory Bowel DiseaseSamuel Meyers, MDSamuel Meyers, MDSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-110-10-845_1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the Editor: The experience of Kozarek and colleagues (1) with methotrexate in the therapy of inflammatory bowel disease is novel and should be pursued. However, a preliminary uncontrolled report including only a few patients is not acceptable. The types of patients studied were variable and the other components of their therapy were not standardized. Certainly the enthusiasm of the investigators and the knowledge that the patients were being studied with a new drug must have influenced the outcome. This possibility is especially true in inflammatory bowel disease which is so difficult to measure.It has been previously shown (2)...References1. KozarekPattersonGelfandBotomanBallWilske RDMVTK. Methotrexate induces clinical and histologic remission in patients with refractory inflammatory bowel disease. Ann Intern Med. 1989;110:353-6. LinkGoogle Scholar2. MeyersJanowitz SH. The "natural history" of ulcerative colitis: an analysis of the placebo response. J Clin Gastroenterol. 1989;11:33-7. CrossrefMedlineGoogle Scholar3. MeyersJanowitz SH. "Natural history" of Crohn's disease. An analytic review of the placebo lesson. Gastroenterology. 1984;87:1189-92. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Mount Sinai Medical Center New York, NY 10029-6574 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 15 May 1989Volume 110, Issue 10Page: 845-845KeywordsDrugsInflammatory bowel diseaseMethotrexate Issue Published: 15 May 1989 PDF DownloadLoading ...
Soluble adhesion molecule P-selectin, von Willebrand factor and fibrinogen in acute stroke: Evidence for early endothelial and haemorheological dysfunction — the West Birmingham stroke project
Authors: Gregory Y.H. Lip, John Zarifis, Andrew Blann, Safat Faroopi, Gian Sagar, Gareth Beevers
Journal: Journal of the American College of Cardiology (1996)
John Dudley Harte
Authors: David Harte
Journal: BMJ (2004)

General practitioner Bedford 1954-79 (b 1916; q St Mary's, Paddington, 1952; FFOM RCP, FRCGP, FRIPHH), d 16 January 2004.

John Dudley Harte studied medicine after wartime service in the Royal Engineers. Before the second world war he had been an insurance claims assessor, and this gave him particular interests in occupational health and also in the relationship between law and medicine. After a number of occupational health appointments he was awarded a research grant to set up a pioneering occupational health department for staff at Bedford Hospital—the first such service, which provided a model for others in the United Kingdom. In 1960 he became an assistant deputy coroner for Bedfordshire and on retiring from general practice and his occupational health appointments he was HM coroner for Bedfordshire. He leaves a wife, Christine, and four children.
Paul Hex Venn
Authors: John Surtees, Peter Nash, Bill Watson, Brian Steer
Journal: BMJ (2008)

Born at Clifton, near Bristol, into a farming family, Paul Hex Venn always had an ambition to be an engineer, but his Australian mother wanted him to train to be a doctor so he said, “I will, but after I qualify I will be an engineer.” While continuing his postgraduate training in London he met the noted anaesthetist Harry Middleton, who encouraged him to take up anaesthesia, where he discovered a love of anaesthetic techniques.

He had a …
Relation between Erythropoiesis and Bone Metabolism in Thalassemia
Authors: Pensri Pootrakul, Suwanna Hungsprenges, Suthat Fucharoen, David Baylink, Emily Thompson, Eugenia English, Minako Lee, James Burnell, Clement Finch
Journal: New England Journal of Medicine (1981)

THE anemia associated with thalassemia provokes a compensatory hyperplasia of the erythroid marrow, which in turn is associated with severe skeletal abnormalities. This study involved two previously splenectomized subjects with anemia and ineffective erythropoiesis. After basal measurements, the two patients were given transfusions to reduce erythropoietin stimulation of the erythroid marrow. This treatment provided an opportunity to evaluate the effect of suppression of erythropoiesis on bone metabolism.Ferrokinetic measurements and studies of erythropoiesis in marrow specimens indicated that rates were more than 10 times normal before transfusion. The bones were osteopenic, with decreased mineralized bone as well as increased osteoid. . . .
Childhood respiratory infection and adult chronic bronchitis in England and Wales
Authors: P. N Lee
Journal: BMJ (1987)

that of Dr Toon and colleagues, show a much higher isolation rate of organisms (table).We found no difference in contraceptive habit or smoking habit between these groups.We agree that many of these isolates can be regarded as normal lower genital tract commensals, but we regard Chlamydia trachomatis, Trichomonas vagi- nalis, and gardnerella as pathogenic organisms.Recent data from Dundee' and Gateshead2 indicate that many women with mildly atypical findings on cervical cytology have cervical intra- epithelial neoplasia requiring treatment.Never- theless, colposcopic facilities are not infinite and it should be remembered that some women with inflammatory smears will have a microbiological infection, which may respond to simple anti- microbial therapy without the need for colposcopic examination.
Recurrent Conjugal Neuralgia Caused by Herpesvirus Hominis Type 2
Authors: Daniel R. Hinthorn
Journal: JAMA (1976)

Leg neuralgia is usually caused by nerve root irritation, and is seldom considered of viral origin. Two married couples had recurrent leg pain in a dermatome distribution. In each episode, after one to three days of neuralgia, herpetic vesicles appear on or near the genitalia. Herpesvirus hominis (HVH) was isolated from vesicles or cervix in three patients and was serologically identified as herpesvirus hominis type 2. Prolonged follow-up has not shown progression of the syndrome or any permanent neurologic damage. Treatment with topical neutral red and photoinactivation has not only reduced local lesion healing time and frequency of attacks, but it has also given prompt relief of neuralgia. (<i>JAMA</i>236:587-588, 1976)
Current Practice of Artificial Insemination by Donor in the United States
Authors: Martin Curie-Cohen, Lesleigh Luttrell, Sander Shapiro
Journal: New England Journal of Medicine (1979)

Abstract Of 711 physicians likely to perform artificial insemination by donor surveyed to determine their current practices, 471 responded, of whom 379 reported that they performed this procedure. They accounted for approximately 3576 births by this means in 1977. In addition to treating infertility, 26 per cent of these physicians used the procedure to prevent transmission of a genetic disease, and 10 per cent used it for single women. Donors of semen were primarily from universities, were only superficially screened for genetic diseases, and were then matched phenotypically to the recipient's husband. Most recipients were inseminated twice per cycle. Only 17 per cent of physicians used the same donor for a given recipient, and 32 per cent used multiple donors within a single cycle. Only 37 per cent kept records on children, and only 30 per cent on donors. The identity of donors usually was carefully guarded to ensure privacy and to avoid legal complications. (N Engl J Med 300:585–590, 1979)
CONTROL OF VENEREAL DISEASE
Authors: Melville Silverberg
Journal: JAMA (1923)

<h3>To the Editor:</h3> —InThe Journal, July 14, appears an editorial on the control of venereal disease. As far as this relates to gonorrhea, there is one important phase which hitherto has lacked the consideration which its relation to the problem has warranted. I refer to the treatment of the all too common acute uncomplicated anterior urethritis in the male. Considering how widespread gonorrhea is, that it is socially deplorable, morally objectionable and economically wasteful in times of peace, and that in times of war it is a serious menace to the success of military enterprise, one wonders at the almost complete absence of any earnest attempt to improve the generally accepted methods of treatment, which are far from efficient. Syphilis has attained scientific approval, and has thereby achieved some dignity; gonorrhea has not, and perhaps for this reason fails to evoke enthusiasm among those whose mental gifts and bent
Effect of Isoproterenol, <i>l</i> -Norepinephrine, and Intraaortic Counterpulsation on Hemodynamics and Myocardial Metabolism in Shock following Acute Myocardial Infarction
Authors: HILTRUD MUELLER, STEPHEN M. AYRES, STANLEY GIANNELLI, E. FOSTER CONKLIN, JAMES T. MAZZARA, WILLIAM J. GRACE
Journal: Circulation (1972)

The effects of isoproterenol, l -norepinephrine, and intraaortic counterpulsation on hemodynamics and myocardial metabolism were evaluated in shock due to acute myocardial infarction. Before treatment, the cardiac index was markedly reduced, averaging 1.35 liters/min/m 2 . Mean aortic pressures ranged from 40 to 65 mm Hg. Decreases in coronary blood flow (mean, 68 ml/100 g/min) and in myocardial oxygen consumption (mean, 8.11 ml/100 g/min) were associated with abnormally high myocardial oxygen extractions (mean, 78%) and with lactate production (mean, 9%). Isoproterenol increased cardiac index 63% and heart rate 26%. Coronary blood flow rose an average of 12 ml/100 g/min in the face of decreased diastolic aortic pressure. Rate of myocardial lactate production increased. l -Norepinephrine increased mean aortic pressure and coronary blood flow an average of 21 mm Hg and 27 ml/100 g/min. Mean myocardial oxygen consumption rose 2.24 ml/100 g/min. While myocardial lactate production shifted to extraction (mean, 12%), myocardial oxygen extraction remained abnormally high (mean, 73%). Cardiac index did not change. Intraaortic counterpulsation increased mean aortic pressure and coronary blood flow an average of 15 mm Hg and 23 ml/100 g/min. Myocardial oxygen consumption remained essentially unchanged. Both myocardial lactate and oxygen extraction improved toward normal values (15 and 61%). Cardiac index increased an average of 0.45 liters/min/m 2 . Hemodynamics and myocardial metabolism then were markedly abnormal in shock due to acute myocardial infarction. Isoproterenol improved cardiac performance but myocardial oxygenation deteriorated. Therefore isoproterenol does not seem to be helpful in coronary shock. 1 -Norepinephrine improved myocardial perfusion and oxygenation, but did not change cardiac output. It appears to be the vasoactive agent of choice in the initial treatment of coronary shock. Intraaortic counterpulsation changed myocardial metabolism toward normal and improved systemic perfusion. Mortality remained unchanged however during the three different therapeutic interventions emphasizing the importance of early recognition of the shock state and of further aggressive diagnostic and therapeutic management.
Inductive reasoning and semantic cognition: More than just different names for the same thing?
Authors: Aidan Feeney, Aimee K. Crisp, Catherine J. Wilburn
Journal: Behavioral and Brain Sciences (2008)

Abstract We describe evidence that certain inductive phenomena are associated with IQ, that different inductive phenomena emerge at different ages, and that the effects of causal knowledge on induction are decreased under conditions of memory load. On the basis of this evidence we argue that there is more to inductive reasoning than semantic cognition.
Deaths from asthma.
Authors: I. W. Grant, W. P. Kennedy, D. N. Malone
Journal: BMJ (1968)

revealed a characteristic alteration of the ganglion cells with many intracytoplasmic membranous structures which are possibly phospholipids (see Figure ).The close morpho- logical resemblance between these inclusions and those described in amaurotic familial idiocy is apparent when comparing the elec- tronmicrograph of a human cerebral ganglion Electronmicrograph of rat ganglion cell from a chloroquine-treated hooded rat (100 mg./kg.daily for 12 months).The cytoplasm contains many membranous structures.cell in Tay-Sachs disease' with our own ob- servation.The striking similarity between the two entities at both the macroscopic and ultrastructural levels suggests the possibility of common features in the pathogenesis of these specific lesions.-Weare, etc.,
Points from Letters: A National Health Authority
Authors: I. T. Patrick
Journal: BMJ (1975)

Ketoprofen, one of the many propionic acid derivatives flooding the market, is the subject of another substantial promotional programme only 12 months after the first. . ..Pharmaceutical companies, it seems, are playing into the hands of "Bennery" witlh such blatant "burning" of profits.. The public can hardly be expected to support the call for more money for the N.H.S. when it seems the medical profession is doing little to discourage such wasteful practices....
TCTAP A-082 Optical Frequency Domain Imaging Guidance for Coronary Stent Implantation in Comparison with Intra Ultrasound Guidance
Authors: Tomoko Kobayashi, Satoru Sasaki, Munemitsu Otagaki, Hideaki Takahashi, Yoshifui Hano, Masahiro Mizobuchi, Atsushi Funatsu
Journal: Journal of the American College of Cardiology (2014)
CASE OF CEREBRAL NEOPLASM SIMULATING DEMENTIA PARALYTICA, WITH OPERATION AND COMPLETE NEUROLOGIC AND MENTAL RECOVERY
Authors: Charles Rosenheck
Journal: JAMA (1923)

That intracranial growths are often responsible for varied psychotic disturbances is well known to neuropsychiatrists. These mental changes may vary from mild alterations to grave psychic defects. Nor is the location of the tumor mass indicative or diagnostic of the psychosis which may be part of the clinical picture. In other words, it would be absurd to attempt localization of an intracranial mass on the evidence furnished by the psychic alterations. One has to depend entirely on the disturbances in neurologic functions for localizing data. Some modifications of these recognized observations may be made, however, in growths involving the frontal lobes. In this area, a fairly well defined psychotic picture unfolds itself, so that, in association with other neurologic signs, one may safely venture a positive localizing diagnosis. The case here reported presented the neurologic signs and the psychiatric picture in a manner so vivid and clear cut that the
Ablation of phospholamban and sarcolipin results in cardiac hypertrophy and decreased cardiac contractility
Authors: Mayilvahanan Shanmugam, Shumin Gao, Chull Hong, Nadezhda Fefelova, Martha C. Nowycky, Lai-Hua Xie, Muthu Periasamy, Gopal J. Babu
Journal: Cardiovascular Research (2010)

Improving the sarco(endo)plasmic reticulum (SR) Ca2+-ATPase (SERCA) function has clinical implications in treating heart failure. The present study aimed to determine the effect of constitutive activation of the SERCA pump on cardiac contractility in normal mice and during pressure-overload-induced cardiac hypertrophy. The SERCA pump was constitutively activated in both atrial and ventricular chambers of the mouse heart by ablating its key regulators, phospholamban (PLN) and sarcolipin (SLN). The double-knockout (dKO) mice for PLN and SLN showed increased SERCA pump activity, Ca2+ transients and SR Ca2+ load, and developed cardiac hypertrophy. Echocardiographic measurements showed that the basal cardiac function was not affected in the young dKO mice. However, the cardiac function worsened upon ageing and when subjected to pressure overload. Our studies suggest that the constitutive activation of the SERCA pump is detrimental to cardiac function. Our findings also emphasize the need for dynamic regulation of the SERCA pump by PLN and/or SLN to maintain cardiac contractility in normal conditions and during pathophysiological states.
Improving fitness and reducing obesity in preschool children
Authors: S. Duncan
Journal: BMJ (2011)

Multidimensional interventions can be effective in migrant populations

We are now in the midst of a global obesity epidemic that extends into early childhood; the World Health Organization estimated in 2010 that more than 42 million children under the age of 5 were overweight.1 Excess fat gain during this crucial developmental period can lay the groundwork for adverse psychological, social, and health outcomes.2 During the preschool years children approach an “adiposity rebound”—a rise in body mass index that occurs between 3-7 years—the timing of which determines the probability of developing obesity later in life.3 Of particular concern is the comparatively high prevalence of overweight and obesity among children from migrant communities and socially disadvantaged backgrounds.4 5 Finding ways to reduce the burden of obesity in these high risk populations is a key priority in many counties. In the linked randomised trial (doi:10.1136/bmj.d6195), Puder and colleagues assess the effect of a multidimensional lifestyle intervention on aerobic fitness and adiposity in predominantly migrant preschool children.6

Poor aerobic fitness has been suggested as an important contributor to obesity in …