tbuckley/cabot-search huggingface dataset:
Risk factors for sensitization to furred pets
Authors: W. Popp, H. Rauscher, K. Serti, T. Wanke, H. Zwick
Journal: Allergy (1990)

The risk factors for sensitization to pets was investigated in 169 male pupils. A recent or former contact with cats, dogs, and guinea pigs in own home was reported in 52 (30.8%), 42 (24.9%), and 20 (11.8%) study subjects, respectively. Clinically manifested allergy was found in two probands to cats and in two others to guinea pigs, three of them had formerly had pets and one proband with allergic rhinitis to cats had never had any pet. Sensitization to animals and aeroallergens was investigated with Phadezym-RAST. Only owners of cats had a higher incidence of cat sensitization than probands without direct contact (26.9% versus 10.3%, P less than 0.01). No statistically significant difference in sensitization to dogs and guinea pigs was found in groups with and without these pets. A strong correlation existed between sensitization to pets and other aeroallergens (house dust mite: P less than 0.025, birch pollen: P less than 0.0001, mugwort: P less than 0.0001, and grass pollens: P less than 0.0001). No association was found between sensitization to pets and smoking history, bronchial hyperreactivity to methacholine or radiological findings of the paranasal sinus.
Randomization in Clinical Trials
Authors: William J. Zimmer, J. Trig Brown, Mark Linzer
Journal: Annals of Internal Medicine (1987)

Letters and Corrections1 November 1987Randomization in Clinical TrialsWILLIAM J. ZIMMER, M.D., J. TRIG BROWN, M.D., MARK LINZER, M.D.WILLIAM J. ZIMMER, M.D.Search for more papers by this author, J. TRIG BROWN, M.D.Search for more papers by this author, MARK LINZER, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-107-5-790_1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: Stamm and associates (1) address an issue of considerable clinical importance. We write to ask for clarification of their use of the term "exclusion," which has direct impact on the analysis and conclusions of their study.Randomization in clinical trials is a method to reduce bias when assigning patients to different treatment regimens (2). To preserve this benefit, strict attention must be paid to preserving the integrity of the groups after randomization. Ideally, subjects not eligible for the protocol are excluded before randomization; this is not always possible in practice. In this report some of the inclusion...References1. STAMM W, MCKEVITT M, and COUNTS G. Acute renal infection in women: treatment with trimethoprim-sulfamethoxazole or ampicillin for two or six weeks. Ann Intern Med. 1987;106:341-5. LinkGoogle Scholar2. FRIEDMAN L, FURBERG C, and DEMETS D. Issues in data analysis. In: Fundamentals of Clinical Trials. Boston: John Wright PSG Inc.; 1982:156-65. Google Scholar3. PETO R, PIKE M, and ARMITAGE P. Design and analysis of randomized clinical trials requiring prolonged observation of each patient: I. Introduction and design. Br J Cancer. 1976;34:585-612. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: WILLIAM J. ZIMMER, M.D.; J. TRIG BROWN, M.D.; MARK LINZER, M.D.Affiliations: Duke University Medical Center Durham, NC 27710 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byClinical Trials in Orthopaedics Research. Part III. Overcoming Operational Challenges in the Design and Conduct of Randomized Clinical Trials in Orthopaedic Surgery 1 November 1987Volume 107, Issue 5Page: 790-790KeywordsClinical trialsPatients ePublished: 1 December 2008 Issue Published: 1 November 1987 PDF downloadLoading ...
MicroRNA 92a-2*: A Biomarker Predictive for Chemoresistance and Prognostic for Survival in Patients with Small Cell Lung Cancer
Authors: Aarati R. Ranade, David Cherba, Shravan Sridhar, Patrick Richardson, Craig Webb, Anoor Paripati, Brad Bowles, Glen J. Weiss
Journal: Journal of Thoracic Oncology (2010)
Cancer death rate falls steadily in England over past decade
Authors: J. Wise
Journal: BMJ (2014)

The death rate from cancer among people aged under 75 fell by 14.7% across England from 2003 to 2013, NHS Outcomes Framework data have shown. However, regional data showed rises in some areas of the country.

The figures, published by the Health and Social Care Information Centre,1 showed that cancer is still the biggest killer of people under 75. A total of 63 458 deaths from cancer occurred in England’s under 75s in 2003, falling to 62 132 in 2013. In every 100 000 people …
Nutrition in Clinical Surgery
Authors: Donald J. Ferguson
Journal: JAMA (1986)

In depleted patients who need elective surgery, the correction of a nutritional deficiency is essential to minimize the risk of complications or death. Surgeons need a handbook to which they can turn for practical and reliable guidance in this important task. Deitel and his 64 coauthors give us a comprehensive and up-to-date tool for this purpose. There are two main sections. The first, on principles and techniques, includes details of enteral and parenteral catheterization, tables of normal values for assessment of nutritional status, model forms for medical records, and the outline of a computer program dealing with body composition, nutritional evaluation, and treatment. The contents of commercially available liquid diets and vitamin supplements are tabulated. Dudrick's essays on nutritional assessment and on home parenteral nutrition are, as would be expected from this pioneer, complete and authoritative. Pediatric patients are discussed in a separate chapter. A policy of presenting each chapter
Cardiac Hydatid Cyst Mimicking Malignancy
Authors: Sabire Yilmaz, Meftune Ozhan, Sait Sager, Metin Halac, Kerim Sonmezoglu, Ilhami Uslu
Journal: Clinical Nuclear Medicine (2011)

A 50-year-old man presented with chest pain symptoms for 7 years. He did not report any other complaints. The diagnostic tests including physical examination, routine laboratory tests, chest x-ray, and electrocardiography were reported as normal. Cardiac MRI, however, revealed a 64 × 66 mm mass lesion in the left myocardium. He was referred to our unit for further tests. A PET/CT was carried out which demonstrated a minimally increased fluorodeoxyglucose uptake at the peripheral margins of the mass, which deemed to be suspicious for malignancy. The patient underwent a thoracotomy and the cardiac mass was excised. Histopathologic examination reported this lesion as a hydatid cyst.
THE HANDITOME: A SIMPLE DEVICE FOR CUTTING SECTIONS
Authors: Hamilton Cooke
Journal: JAMA (1928)

To facilitate the cutting of sections without the use of a microtome, I have devised a simple instrument which is called a handitome. In principle the handitome is a clamp 11 cm. long and 2.5 cm. high, except 2 cm. from the jaw where the height is 1 cm. The clamp is held together by a screw and a spring which are placed 5 cm. from the tip of the jaw. The distal 0.5 cm. of the left jaw and 1 cm. of the right jaw are bent so that, when the clamp is open 0.5 cm., the right and left bend are in line and form a right angle with the straight arms (fig. 1). The essential requirements which must be observed in the construction of the handitome are that the angles must be sharp and the lateral flares be on a straight line when the jaws are
The risk of advanced heart block in surgical patients with right bundle branch block and left axis deviation.
Authors: J O Pastore, P M Yurchak, K M Janis, J D Murphy, L M Zir
Journal: Circulation (1978)

The risk of advanced atrioventricular block during anesthesia was studied prosepctively in 44 patients with right bundle branch block and left axis deviation who underwent a total of 52 operations over a 14 month period. All patients had continuous electrocardiographic monitoring throughout anesthesia induction, operation, and surgical recovery. Of the 52 operative procedures, 24 were done under general anesthesia, 11 under spinal, and 17 under local. The preoperative cardiac rhythms were atrial fibrillation in two patients, atrial tachycardia with block in one patient, atrial flutter in one patient, and sinus rhythm in the remaining patients. Temporary pacemakers were inserted preoperatively in six patients, usually because of PR interval prolongation on the preoperative electrocardiogram. There was only one episode of transient complete heart block in 51 of the 52 operative procedures. In two of the six patients with temporary pacemakers, significant pacer-related ventricular irritability occurred. This study indicates that temporary pacemaker insertion is rarely required in patients with chronic right bundle branch block and left axis deviation who require noncardiac surgery.
TCT-144 Randomized Comparison Study Assessing the Impact of Cilostazol on Heart Rate and Arrhythmias by 24-hour Ambulatory Holter Electrocardiographic Monitoring after Drug-Eluting Stent Implantation in Coronary Artery Disease
Authors: Beom-June Kwon, Sang-Hyun Ihm, Hee-Yeol Kim, Su-Hyun Lee, Ki-Bae Seung, Ho-Joong Youn
Journal: Journal of the American College of Cardiology (2013)
German science minister tries to rescue Lubeck university hospital from closure
Authors: A. Tuffs
Journal: BMJ (2010)

Students, academics, and politicians have criticised the state government of Schleswig-Holstein, in northern Germany, over its plans to close the university hospital and medical faculty in Lubeck.

From autumn 2011 no new medical students will be accepted by the university, and current students will be transferred to the university hospital in Kiel, about 60 km away. The state hopes to save €24m (£20m; $30m) a year with the …
Vasodilators in senile dementia.
Authors: W P Maclay
Journal: BMJ (1979)

general condition improved rapidly from that time.However, the oedema continued to extend across his chest wall and his left arm and, more worry- ingly, up into his neck; and at one point we began to consider the possibility that tracheostomy would be required.Happily this did not prove necessary, but it was not until 4 August that the oedema began to recede, and on 13 August when the boy was discharged from hospital supervision there was still some residual swelling of his right arm.
Do Diuretics Cause Heart Disease?
Authors: Edward D. Freis
Journal: Annals of Internal Medicine (1995)

Letters1 December 1995Do Diuretics Cause Heart Disease?Edward D. Freis, MDEdward D. Freis, MDVeterans Affairs Medical Center; Washington, DC 20422Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-123-11-199512010-00018 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail IN RESPONSE:Most of the evidence presented by Drs. Shivkumar and Narins concerns potassium depletion produced by dietary restriction or by low potassium perfusates of tissues rather than depletion produced by administration of diuretics. Results obtained by such methods may not be relevant to hypokalemia produced by thiazide diuretics. For example, I am not aware of any definite evidence that either short- or long-term administration of diuretics leads to damaged renal function or structure or that either leads to muscle weakness or paralysis.The reference to the possibility that diuretic-induced hypokalemia may cause a reduction in phase-4 depolarization is inappropriate. ...References1. Holland OB, Nixon JV, Kubnert L. Diuretic-induced ventricular ectopic activity. Am J Med. 1981; 770:767-8. Google Scholar2. Freis ED. The efficacy and safety of diuretics in treating hypertension. Ann Intern Med. 1995; 122:223-6. Google Scholar3. Papademetriou V, Fletcher R, Khatri IM, Freis ED. Diuretics induced hypokalemia in uncomplicated systolic hypertension: effect of plasma potassium correction on cardiac arrhythmias. Am J Cardiol. 1983; 52:1358-60. Google Scholar Author, Article, and Disclosure InformationAuthors: Edward D. Freis, MDAffiliations: Veterans Affairs Medical Center; Washington, DC 20422 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 December 1995Volume 123, Issue 11 Page: 891-892 Keywords Action potentials Arrhythmia Cardiovascular therapy Depolarization Diuretics Electrocardiography Hypertension Muscles Paralysis Potassium ePublished: 15 August 2000 Issue Published: 1 December 1995 Copyright & PermissionsCopyright © 1995 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Psychomaintenance Aspects of Alexithymia: Relationship to Medical Outcome Variables in a Chronic Respiratory Illness Population
Authors: James H. Kleiger, Jerald F. Dirks
Journal: Psychotherapy and Psychosomatics (1980)

MMPI alexithymia scores and MMPI panic-fear personality scores were calculated for 202 adult asthmatic patients. Both sets of scores were shown to be related to the number of days rehospitalized. In addition, patients who scored high on both the alexithymia and panic-fear personality scales were judged by their attending physicians as being more severelly ill than other patients. Both of these relationships were independent of the objective severity of the patient's asthma as indexed by longitudinal pulmonary functions. The study highlights the fact that alexithymia and panic-fear are two dimensions which may contribute to medical intractability in chronic asthma.
'Both sides need to keep the relationship going'
Authors: R. Persaud
Journal: BMJ (2003)

The doctor-patient relationship has never fully recovered from Freud. Before the advent of psychoanalysis, patients went to doctors, who administered a treatment—perhaps a tablet or a procedure. The relationship between physicians and client was not the primary issue; it was merely a mechanism that facilitated delivery of the treatment. After the Freudian revolution, the relationship between doctor and patient could itself become the prescription.

Is it now a doctor's remit to provide the kind of positive supportive relationship that is difficult to find elsewhere? Even if doctors were willing to shoulder this project, the public should beware. Harold Shipman was, after all, by many accounts, popular with his patients.

In Freudian analysis much of the work of the “doctor” is to think hard and analyse the nature of the relationship that develops with the client. The doctor even has to relentlessly question his or her personal emotional reaction to the patient, and analyse that, partly to ensure the doctor-patient relationship can survive the physician's own neuroses. This relationship thing is getting …
The first year of life: development surveillance at 8 months.
Authors: H B Valman
Journal: BMJ (1980)

The mother should be asked whether she has any problems and whether the infant has had any illnesses since the last examination.She is also asked whether the infant is making sounds and the details of his diet, in particular whether he is chewing solids.As at 6 weeks, the infant's alertness and interest are checked.His head circumference and weight should be measured and plotted on the growth chart.
Safety profile of boceprevir and telaprevir in chronic hepatitis C: Real world experience from HCV-TARGET
Authors: Stuart C. Gordon, Andrew J. Muir, Joseph K. Lim, Brian Pearlman, Curtis K. Argo, Ananthakrishnan Ramani, Benedict Maliakkal, Imtiaz Alam, Thomas G. Stewart, Monika Vainorius, Joy Peter, David R. Nelson, Michael W. Fried, K. Rajender Reddy
Journal: Journal of Hepatology (2014)
Effect of mutations in Pneumocystis carinii dihydropteroate synthase gene on outcome of P carinii pneumonia in patients with HIV-1: a prospective study
Authors: Thomas R Navin, Charles B Beard, Laurence Huang, Carlos del Rio, Sherline Lee, Norman J Pieniazek, Jane L Carter, Thuy Le, Allen Hightower, David Rimland
Journal: The Lancet (2001)
Assessment of international differences in 30-day event of death and reinfarction amongst patients with acute coronary syndromes: insights from GUSTO IV ACS
Authors: William K. Midodzi, Wei-Ching Chang, Yuling Fu, Eric Boersma, J. Cooper, Elliot Barnathan, Maarten L. Simoons, Lars Wallentin, E.Magnus Ohman, Paul W. Armstrong
Journal: Journal of the American College of Cardiology (2002)
Calcium accumulating and ATPase activity of cardiac sarcoplasmic reticulum before and after birth
Authors: W. G. NAYLER, E. FASSOLD
Journal: Cardiovascular Research (1977)

The possibility that the cardiac SR undergoes developmental changes at about the time of birth, and that these changes affect its ability to accumulate Ca2+ and to hydrolyse ATP has been studied. SR-rich microsomal fractions were prepared from heart muscle excised from foetal guinea pigs and rabbits 1 day before their anticipated date of birth, and from 1 day old and adult animals. For control purposes microsomes were also prepared from the relevant maternal stock animals. One day before birth the cardiac microsomes of the foetal but not of the maternal animals exhibited a decreased ability to accumulate Ca2+ by uptake but not by the binding process, and a decreased ability to hydrolyse ATP. This reduction in ATPase activity involved both the Ca2+-de-pendent and the Ca2+-independent ATPase enzymes. One day after birth the Ca2+-accumulating activity of the neonatal microsomes had increased, that of the rabbit via an increase in Ca2+ uptake and that of the guinea pig by an increase in Ca2+ binding. These changes were accompanied by an increase in the activity of the Ca2+-dependent ATPase. The results are interpreted to mean that the cardiac SR changes at about the time of birth, and that although the pattern of these changes may be species specific they result in an increase in the Ca2+-accumulating activity of the SR.
Man wins battle to keep receiving life support
Authors: Owen Dyer
Journal: BMJ (2004)

A terminally ill man who feared doctors might one day stop feeding him has won a landmark judgment ensuring that his wish for life supporting treatment will be respected.

Leslie Burke, aged 44, from Lancaster has degenerative cerebellar ataxia and is likely to lose the ability to communicate. He sought judicial review of the General Medical Council's 2002 guidance on withholding and withdrawing life prolonging treatment, arguing that it breached articles 2 and 3 of the European convention on human rights—the right to life and the right to be spared inhuman and degrading treatment. …
Genome-Wide Screen Identifies Genes Whose Inactivation Confer Resistance to Cisplatin in<i>Saccharomyces cerevisiae</i>
Authors: Ruea-Yea Huang, Martha Eddy, Marija Vujcic, David Kowalski
Journal: Cancer Research (2005)

Abstract To identify novel genes that mediate cellular resistance to cisplatin, we have screened the collection of Saccharomyces cerevisiae deletion strains. We have found reproducibly 22 genes/open reading frames (ORF), which when deleted, confer resistance to cisplatin at a concentration that is lethal to wild-type cells. Complementation of individual deletion strains with the corresponding wild-type gene abolished cisplatin resistance, confirming that specific gene deletions caused the resistance. Twenty of the genes/ORFs identified have not been previously linked to cisplatin resistance and belong to several distinct functional groups. Major functional groups encode proteins involved in nucleotide metabolism, mRNA catabolism, RNA-polymerase-II–dependent gene regulation and vacuolar transport systems. In addition, proteins that function in ubiquitination, sphingolipid biogenesis, cyclic AMP–dependent signaling, DNA repair, and genome stability are also associated with cisplatin resistance. More than half of the identified genes are known to have sequences or functional homology to mammalian counterparts. Some deletion strains are cross-resistant to selected cytotoxic agents whereas hypersensitive to others. The sensitivity of certain resistant strains to other cytotoxic agents suggests that our findings may point to particular drug combinations that can overcome resistance caused by inactivation of specific genes.
PRIMARY SARCOMA OF THE LUNG.
Authors: A. F. BOCK
Journal: JAMA (1889)

On the 13th of September, 1888, I was called to see Bertha F., æt. 5, of German parentage. Family history exceptionally good, parents strong and healthy. Patient had four sisters and one brother, all healthy. Grandparents still living with the exception of the maternal grandmother, who died about two years ago of chronic senile gangrene. According to the mother's tstaement the child had been ill since about July 20 last, when she was taken with a high fever (105°) and complained of severe pain in her left side; which continued with more or less severity until she died. As the fever yielded to quinine it was no doubt of malarial origin. While under my observation there was no increase of temperature, no cough nor expectoration. The right half of the body was constantly bathed in perspiration, the left always dry. There was very little desire for food, but no difficulty
Reversible Pseudo-Pelger Anomaly Related to Sulfisoxazole Therapy
Authors: Jerrold M. Kaplan, O'Neill Barrett
Journal: New England Journal of Medicine (1967)

The Pelger-Huët anomaly of granulocytic leukocytes is a benign hereditary disorder1 characterized by poor segmentation and condensation of nuclear chromatin.2 In the heterozygous state the vast majority of nuclei are rodlike or bilobed; in the rare homozygous condition, there is a complete lack of nuclear segmentation, all the nuclei showing a round or slightly indented appearance.3 Morphologic changes resembling the Pelger-Huët anomaly (acquired pseudo-Pelger anomaly) have been described in several myeloproliferative diseases.4 This report deals with a case of acquired pseudo-Pelger anomaly in association with drug fever and rash secondary to the administration of sulfisoxazole (Gantrisin).Case ReportA 27-year-old . . .
Transpapillary Biopsies and Brush Cytology from the Common Bile Duct
Authors: L. Aabakken, R. Kåresen, A. Serck-Hanssen, M. Osnes
Journal: Endoscopy (1986)

This study comprises 29 patients with a stricture of the common bile duct of unknown etiology, in whom an attempt was made endoscopically to take a biopsy from the ductal wall, in order to establish the diagnosis. Biopsies were obtained from all patients. Follow-up permitted definite diagnosis in 17 patients, from surgery or biopsy. The endoscopic biopsy diagnosis (malignant/benign) proved to be correct in 10 patients, falsely negative in 4. Two were "uncertain malignant" and 1 "not representative". No false positives were seen. Brush cytology provided no additional information. No complications due to the procedure were seen. The results imply that the procedure might be helpful in the evaluation of these patients.