tbuckley/cabot-search huggingface dataset:
Urine Telomerase and Bladder Cancer Detection
Authors: Brian C.-S. Liu
Journal: JAMA (2006)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
National Health Insurance: The Need for Reasoned Analysis
Authors: Anne R. Somers
Journal: New England Journal of Medicine (1971)

Some form of national health insurance for the United States appears inevitable. This is inherent in the supply-and-demand factors affecting the availability and cost of health care. Every new advance in the science and technology of medicine and every new increment that is added to the life expectancy of the American people or to their health expectations mean that more care will be sought and given and that a higher proportion of family and national income will be spent for this purpose. Some device for spreading this mounting cost over the entire population, in as equitable a manner as possible, . . .
An Abdominal Catastrophe Which Did Not Take Place
Authors: G. E. Parker
Journal: BMJ (1941)

WAR DIFFICULTIES IN DIABETIC DIETSBRITISH 119 be tried as a test diet: if it fails and insulin is necessary, then more carbohydrate-15 or more blacks (150+ grammes C.)-should be given in a definite arrangement to balance the insulin and the protein and fat (some 10 red portions) eaten at the various meals as desired and as most convenient.Now that protein supplies are scarce the insulin patient is fortunate in being able to increase his carbohydrate if he cannot obtain his pre-war amounts of protein and fat in quantities sufficient to safeguard weight and energy and prevent hunger.This may require a slight increase in insulin, but not in every case.If, therefore, he cannot get all his previous protein and fat, his health need not suffer if he uses more carbohydrate, and insulin when necessary.A prescription of 15 to 20 blacks and only 6 to 10 reds will usually keep him in vigorous health.
Passive smoking and cardiorespiratory health in Scotland: Authors' reply
Authors: D. J Hole, C. R Gillis, V. M Hawthorne
Journal: BMJ (1990)

accumulated 153 deaths from lung cancer and many thousands of deaths from ischaemic heart disease in non-smokers.The effect of passive smoking on lung cancer has been looked into.6It is a pity that its effect on ischaemic heart disease has not.
Independent samples t test
Authors: P. Sedgwick
Journal: BMJ (2010)

A new programme of goal oriented visits from a rheumatologist was devised for patients in primary care with osteoarthritis of the knee.1 The new programme was assessed using a randomised controlled trial to ascertain whether it provided benefits in terms of weight management and physical activity. The control treatment was usual care. A total of 154 patients were randomised to the new programme (three goal oriented standardised consultations) and 182 to usual care. At four months, the mean weight loss for patients who received standardised consultations was on average greater than for those receiving usual care (mean 1.11 (SD 2.49) kg v 0.37 (SD 2.39) kg; P=0.007). The two groups were statistically compared using a two sided, independent samples t test with a 0.05 (5%) critical level of significance ( t =2.77, degrees of freedom=334). Which of the following statements, if any, are true?
Cardiac mass in glucocorticoid-hypertensive rats with and without circulating adrenaline
Authors: J. F BURRIS, B. WAEBER, H. R BRUNNER
Journal: Cardiovascular Research (1985)

There is evidence that catecholamines may promote the development of cardiac hypertrophy in hypertension. To test the hypothesis that adrenaline directly determines left ventricular mass, normotensive Wistar rats were made adrenaline-deficient by adrenalectomy and hypertensive by administration of glucocorticoid. Blood pressure, heart rate, and body weight of the adrenalectomised group were not significantly different from a glucocorticoid treated control group with intact adrenals. Heart weight was significantly lower in the adrenalectomised rats, but this difference disappeared when heart weight was adjusted for body weight. It appears therefore that the presence or absence of adrenaline does not significantly affect cardiac mass in the presence of hypertension in this animal model.
Caring for the Burned: Life and Death in a Hospital Burn Center
Authors: Norman R. Bernstein
Journal: JAMA (1986)

James M. Mannon, PhD, has produced a precise and focused sociological exposition of the operation of a burn unit. It was achieved after careful observation of the activities on such a ward and many weeks and months of interviewing physicians, nurses, physical therapists, and social workers, as well as patients and their relatives. He intended to learn as much as he could about the "social world of burn recovery... from the viewpoint of the participants," and he has generally achieved this goal. There is little of the dramatic in his writing. His attitude toward the caretakers is rather critical. For example, Mannon feels that patients in pain could complain only in limited ways that did not annoy other patients or disrupt the functioning or professional calm of the staff. He also gives illustrations of staff members threatening patients to induce them to comply with treatment with remarks like, "Eat or
OCCURRENCE OF DELAYED HYPERSENSITIVITY DURING THE DEVELOPMENT OF ARTHUS TYPE HYPERSENSITIVITY
Authors: S. B. Salvin
Journal: The Journal of Experimental Medicine (1958)

Guinea pigs were injected in the footpads with either purified diphtheria toxoid or recrystallized egg albumin in Freund adjuvant without mycobacteria. Each guinea pig was then skin-tested only once with the specific antigen and bled for antibody determination. After injection of the sensitizing antigen, a latent period occurred during which neither sensitivity nor circulating antibody could be detected. A period of delayed sensitivity followed wherein circulating antibody could not be discerned and which could be transferred by lymph node cells. Ultimately, the Arthus type sensitivity developed, accompanied by circulating antibody. The duration and severity of reactions to homologous antigens during the last 2 phases varied with the antigen and with the dose. An increase in the sensitizing dose decreased the duration of the delayed type of allergy, a decrease in the dose prolonged the delayed type. Inclusion of mycobacterium in the sensitizing inoculum tended to introduce delayed sensitivity earlier and delay the onset of Arthus type sensitivity. When specific precipitate in antibody excess was included with the toxoid in the sensitizing dose, the onset of the Arthus phase was hastened. When lymph nodes from a large number of sensitized donors were removed during the latter part of the latent period, recipients of the cells showed a delayed type sensitivity.
Functional significance of renal prostacyclin and thromboxane A2 production in patients with systemic lupus erythematosus.
Authors: C Patrono, G Ciabattoni, G Remuzzi, E Gotti, S Bombardieri, O Di Munno, G Tartarelli, G A Cinotti, B M Simonetti, A Pierucci
Journal: Journal of Clinical Investigation (1985)

We have examined the urinary excretion of stable immunoreactive eicosanoids in 23 female patients with systemic lupus erythematosus (SLE), 16 patients with chronic glomerular disease (CGD), and 20 healthy women. SLE patients had significantly higher urinary thromboxane B2 (TXB2) and prostaglandin (PG) E2 excretion and significantly lower 6-keto-PGF1 alpha than did healthy women. In contrast, CGD patients only differed from controls for having reduced 6-keto-PGF1 alpha excretion. The group of SLE patients with active renal lesions differed significantly from the group with inactive lesions for having a lower creatinine clearance and urinary 6-keto-PGF1 alpha and higher urinary TXB2. Higher urinary TXB2 excretion was associated with comparable platelet TXB2 production in whole blood, undetectable TXB2 in peripheral venous blood, and unchanged urinary excretion of 2,3-dinor-TXB2. A significant inverse correlation was found between urinary TXB2 and creatinine clearance rate (CCr). In contrast, the urinary excretion of 6-keto-PGF1 alpha showed a significant linear correlation with both CCr and para-aminohippurate clearance rate (CPAH). In four SLE and seven CGD patients, inhibition of renal cyclooxygenase activity by ibuprofen was associated with a significant reduction in urinary 6-keto-PGF1 alpha and TXB2 and in both CCr and CPAH. However, the average decrease in both clearances was 50% lower in SLE patients than in CGD patients, when fractionated by the reduction in urinary 6-keto-PGF1 alpha or PGE2 excretion. We conclude that the intrarenal synthesis of PGI2 and TXA2 is specifically altered in SLE. Such biochemical alterations are associated with changes in glomerular hemodynamics and may play a role in the progression of SLE nephropathy.
Abstract 738: Re-irradiation for recurrent malignant glioma by boron neutron capture therapy
Authors: Shinji Kawabata, Shin-Ichi Miyatake, Ryo Hiramatsu, Toshihiko Kuroiwa, Koji Ono
Journal: Cancer Research (2012)

Abstract OBJECTIVE: Boron neutron capture therapy (BNCT) is based upon the nuclear reaction that occur when non-radioactive boron-10 (10B) is irradiated with low energy neutrons to produce high energy a particles (10B[n, alpha] 7Li). In order for BNCT to be successful, a sufficient amount of 10B and neutrons must be delivered to the tumor. We have applied tumor selective particle radiation known as boron neutron capture therapy (BNCT) to malignant brain tumors. As there has been no standard treatment for recurrent gliomas so far, it has been difficult to evaluate the results of BNCT for recurrent malignant gliomas. Here we introduce the survival benefit of BNCT for recurrent malignant glioma patients, with special reference to new RPA classification recurrent malignant gliomas advocated by New Approaches to Brain Tumor Therapy CNS Consortium (NABTT, JCO 2007). METHODS: Since 2002, we have treated 27 cases of recurrent malignant gliomas with BNCT. All cases had been treated by standard treatment including radiotherapy mainly by XRT prior to BNCT. After BNCT, patients were followed by MRI and F-BPA (amino acid)-PET. Cause of death was estimated by these modalities. Also overall survival was evaluated with special reference to RPA classes advocated by NABTT as above. RESULTS: All cases showed radiographical improvement at once. The median survival time (MST) of BNCT-treated recurrent gliomas was 10 months, while that of total NABTT cases (N=333) was 7 months. MST of NABTT RPA classes were 25.7, 17.2, 3.8, 10.4, 5.6, 6.4 and 4.9 months for classes 1 to 7, respectively. The MST of BNCT-treated cases were 33, 24, 10, 9, 9, 12 and 11, for classes 1 to 7, respectively. BNCT showed good survival benefit especially for the most poor prognostic group (RPA class 3+7) from 4.4 months (NABTT) to 9.6 months. Conclusion: BNCT could prolong the survival of patients with recurrent gliomas not only for the good prognosis group but also for the poor prognosis group. Some of the prognostic factors of malignant glioma, such as KPS, tumor location, extent of surgery, are not independent factor each other. BNCT seems to have the survival benefits for such situations due to its tumor cell selectivity. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 103rd Annual Meeting of the American Association for Cancer Research; 2012 Mar 31-Apr 4; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2012;72(8 Suppl):Abstract nr 738. doi:1538-7445.AM2012-738
Case of Sudden Death Occurring during the Inhalation of Ether
Authors: G. M. Lowe
Journal: BMJ (1877)

years since.The fact that we cannot keep an edition of any standard work on surgery for more than a few years proves this.Antiseptic surgery itself has a history of but a few years, ophthalmic surgery is completely revolutionised; the laryDgoscope is of recent date; the most recent discovery in the treatment of spinal disease is hardly one year old; gynaecological surgery is, comparatively speaking, a new science.You may recollect my advocacy of the general substitution of ether for chloroform in this city hardly a year past: these and a thousand other "innovations" are easily recalled to mind when we are reflecting on the progress of a modern surgery.[After a few remarks on the necessity of a proper supply of appli- ances in hospitals, and a reference to the assistance which good nurses afforded to the clinical teacher, Dr. Jones addressed the students present, giving them advice as to their conduct in the hospital ward and tLe operating theatre.]
Interference in the Effect of Dexamethasone by Diphenylhydantoin
Authors: Emile E. Werk, Young Choi, Leon Sholiton, Charles Olinger, Naeem Haque
Journal: New England Journal of Medicine (1969)

INTERACTION between drugs is recognized, currently, as a serious problem in clinical medicine. High on the list of possibilities are interferences between steroid hormonal compounds and various drugs because of the known similarities in their metabolism.1 We first became aware of an inhibitory effect of diphenylhydantoin (DPH) on the action of dexamethasone several years ago during studies in which DPH was evaluated therapeutically for Cushing's syndrome.2 Initially, the interaction was considered unique in this condition, and subsequent observations in other patients demonstrated only a slight interference in the excretion of urinary 17-hydroxycorticosteroids (17-OHCS) during standard dexamethasone suppression tests. More recently, . . .
Some experience in an area health authority child health clinic.
Authors: R S Illingworth
Journal: BMJ (1979)

Three years9 experience as a doctor taking two clinics a week in an area health authority child health clinic was reviewed. A wide range of clinical conditions was seen, including: problems associated with feeding in breast- and bottle-fed infants; minor developmental abnormalities (mental, behavioural, and physical); surgical and orthopaedic conditions requiring treatment; medical conditions, mainly respiratory and alimentary infections, skin conditions, and problems of over-treatment for minor ailments; and minor genetic abnormalities. Mothers asked for advice on a wide range of topics, risks and benefits of immunisation being the most common. The clinic doctor needs a wide experience in paediatrics to deal with such problems. It is suggested that all lecturers in child health and paediatric and senior registrars should take one clinic a week for six months, and all medical students should attend some clinics as part of their paediatric training. Health visitors have an important role in helping the clinic doctor, but their training should be more realistic and appropriate facilities should be provided to keep them up to date in their work.
Histamine-2 Receptor Blockers and Delirium
Authors: P. V. Nickell
Journal: Annals of Internal Medicine (1991)

Letters15 October 1991Histamine-2 Receptor Blockers and DeliriumP. V. Nickell, MDP. V. Nickell, MDSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-115-8-658_1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editors:I read with interest the article by Cantu and Korek (1) in which they reviewed the literature on central nervous system reactions to histamine-2 receptor (H2) blockers. As the chief of a psychiatry consultation service in a university teaching hospital, I have seen at least five cases of delirium (as defined by the DSM-II-R [2]) associated with H2 blocker use. In all five cases, however, the medication was being given intravenously. Thus, I was surprised that the authors did not address the route of administration in their discussion of risk factors. A MEDLINE literature search yielded no...References1. CantuKorek TJ. Central nervous system reactions to histamine-2 receptor blockers. Ann Intern Med. 1991;114:1027-34. LinkGoogle Scholar2. SpitzerWilliams RJ eds. Diagnostic and Statistical Manual of Mental Disorders. 3d ed. Washington, D.C.: The American Psychiatric Association; 1987:103. Google Scholar1. CantúKorek TJ. Central nervous system reactions to histamine-2 receptor blockers. Ann Intern Med. 1991;114:1027-34. LinkGoogle Scholar2. CerraSchentagMcMillenKarawandeFitzgeraldLeising FJMSGM. Mental status, the intensive care unit and cimetidine. Ann Surg. 1982;196:565-70. CrossrefMedlineGoogle Scholar3. HughesReedSerjeant JWC. Mental confusion associated with ranitidine [Letter]. Med J Aust. 1983;2:12-3. CrossrefMedlineGoogle Scholar4. Silverstone P. Ranitidine and confusion [Letter]. Lancet. 1984;1:1071. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: West Virginia University School of Medicine Morgantown, WV 26506 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byRanitidine-lnduced Bradycardia in a Patient With DextrocardiaRanitidine-Induced Bradycardia in a Patient With DextrocardiaGastrointestinal drugs 15 October 1991Volume 115, Issue 8Page: 658-658KeywordsCentral nervous systemDeliriumMedical risk factorsRoutes of administration Issue Published: 15 October 1991 PDF downloadLoading ...
“The assumption of separate senses”: Pervasive? Perhaps – Persuasive? Hardly!
Authors: Beatrix Vereijken, H.T. A (John) Whiting
Journal: Behavioral and Brain Sciences (2001)

We show that Stoffregen & Bardy's arguments against the assumption of separately functioning senses have more historical antecedents than they give credit for, and that multimodal functioning – primitive in perceptual and brain development – does not require this assumption. What is needed is evidence that biological organisms are indeed detecting and acting upon information in a multimodal (or global) array.
Improving the quality of the cannabis debate: defining the different domains
Authors: J. Strang
Journal: BMJ (2000)

The policy debate on cannabis has moved back into prominence in Britain and elsewhere after reports of increases in use during the early 1990s1 and renewed claims about the therapeutic value of marijuana. 2 3 Rational debate has often been obstructed because the media present a forced choice between two sets of views. One of these constructed views is that cannabis is harmless when used recreationally, is therapeutically useful, and hence should be legalised. The other is that recreational use is harmful to health and that cannabis should continue to be prohibited for recreational or therapeutic purposes.4

This oversimplification of the cannabis debate has prevented a more considered examination of eight conceptually separate issues (box). We believe that a competent consideration of these issues would contribute to a more informed debate about the appropriate public policies that could be adopted towards cannabis use for recreational or therapeutic purposes.

#### Summary points

Cannabis use is increasing steadily in many countries and is most prevalent among young people

The value of the debate on cannabis is seriously diminished by heated contributions that obstruct rational consideration of important public health and policy issues

The different domains of the debate should be considered in isolation at first to allow a more objective analysis of the evidence

Substantial public investment in research into the different areas is a prerequisite of rational consideration of public policies

More than 60 different cannabinoids and over 400 active components have been identified in samples of cannabis.2 However, our interest and concerns about associated harms could be much more focused. Should we be especially concerned about the use of new cannabis preparations with higher concentrations of tetrahydrocannabinol? Does using cannabis that has a higher tetrahydrocannabinol content result in a higher intake of tetrahydrocannabinol or do smokers consciously or subconsciously titrate …
Preclinical and clinical efficacy of XPO1/CRM1 inhibition by the karyopherin inhibitor KPT-330 in Ph+ leukemias
Authors: Christopher J. Walker, Joshua J. Oaks, Ramasamy Santhanam, Paolo Neviani, Jason G. Harb, Gregory Ferenchak, Justin J. Ellis, Yosef Landesman, Ann-Kathrin Eisfeld, Nash Y. Gabrail, Carrie L. Smith, Michael A. Caligiuri, Peter Hokland, Denis Claude Roy, Alistair Reid, Dragana Milojkovic, John M. Goldman, Jane Apperley, Ramiro Garzon, Guido Marcucci, Sharon Shacham, Michael G. Kauffman, Danilo Perrotti
Journal: Blood (2013)
Death Due to Overheated Dialysate During Dialysis
Authors: ROBERT W. FORTNER
Journal: Annals of Internal Medicine (1970)

A patient died during hemodialysis with the Travenol recirculating single-pass dialyzer after exposure of extracorporeal blood to overheated dialysate. A thermostat failure appears to have been the cause of this dialysis accident. Modifications in the dialysis procedure are presented for prevention of this complication.
Depression of the Epigastric and Hypochondriac Regions on Deep Inspiration not always Indicative of Diaphragmatic Paralysis
Authors: T. Harris
Journal: BMJ (1892)

DIAPHRAGMATIC PARALYSIS.quently no shortening, in fact sometimes slight lengthening.In excision, on the other hand, the results as regards shorten- ing are very bad, especially in the knee-joint; hence in children excision of the knee is almost absolutely contrain- dicated.This also holds good as regards other joints, though no doubt to a less extent.Even after excision of the hip, more especially where the trochanter is interfered with very serious shortening sometimes occurs, and I see a case from time to time where excision of the hip was performed in a boy 4a years old, and where eleven years later there was 11 inches of shortening.It has been stated, as regards the knee, that if intraepiphysial excision is performed the inter- ference wita growth is not great, and Hoffa advocates this operation strongly.His experience is, however, almost unique, and there seems no doubt that in many cases of intraepiphysial excision serious interference with growth results.