A NEW AND ECONOMICAL DESICCATING PROCESS PARTICULARLY SUITABLE FOR THE PREPARATION OF CONCENTRATED PLASMA OR SERUM FOR INTRAVENOUS USE: THE ADTEVAC PROCESS
Authors: Joseph M. Hill, David C. Pfeiffer
Journal: Annals of Internal Medicine (1940)

Article1 August 1940A NEW AND ECONOMICAL DESICCATING PROCESS PARTICULARLY SUITABLE FOR THE PREPARATION OF CONCENTRATED PLASMA OR SERUM FOR INTRAVENOUS USE: THE ADTEVAC PROCESSJOSEPH M. HILL, M.D., DAVID C. PFEIFFER, M.E.JOSEPH M. HILL, M.D.Search for more papers by this author, DAVID C. PFEIFFER, M.E.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-14-2-201 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptA practical and inexpensive desiccation process is vital to the development of the widespread use of plasma and serum (ordinary or convalescent) because it solves two main problems in this field. First, storage difficulties practically cease to exist. While it is true that liquid serum may be stored, even without refrigeration as emphasized recently by Levinson,1there is no margin of safety. Contamination with but one bacterium could quickly spoil this excellent culture medium if stored without refrigeration. Also at room temperatures, the antibodies, prothrombin and other valuable biological properties rapidly deteriorate. By contrast, serum stored in the dry so-called...Bibliography1. LEVINSONNEUWELTNECHELESE SOFH: Human serum as a blood substitute in the treatment of hemorrhage and shock, Jr. Am. Med. Assoc., 1940, cxiv, 455-461. Google Scholar2. KOLMERRICHTERLYNCH JACEER: Lyophile complement fixation test for syphilis, Am. Jr. Clin. Path., 1938, viii, 522-528. CrossrefGoogle Scholar3. SHAKELL FF: An improved method of desiccation with some applications to biological problems, Am. Jr. Physiol., 1909, xxiv, 325-340. CrossrefGoogle Scholar4. ELSERTHOMASSTEFFEN WJBAGI: Desiccation of sera and other biological products (including microörganisms) in the frozen state with preservation of original qualities of products so treated, Jr. Immunol., 1935, xxviii, 433-473. 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GREAVESADAIR RIME: High-vacuum condensation drying of proteins from frozen state, Jr. Hyg., 1939, xxxix, 413-445. Google Scholar17. BAUERPICKELS JHEG: Apparatus for freezing and drying virus in large quantities under uniform conditions, Jr. Exper. Med., 1940, lxxi, 83-88. CrossrefGoogle Scholar18. LEDNUM JM: Theory of adsorption. Read before Industrial Gas Section, sixteenth annual convention and exhibition of Am. Gas Assoc., Atlantic City, N. J., (Oct. 30), 1934. Google Scholar19. LEVINSON SO: Personal communication. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Dallas, Texas*Read at the annual meeting of the Texas Club of Internal Medicine, Dallas, February 16, 1940.From the Department of Pathology, Hospital Laboratory Division, Baylor University College of Medicine. Nextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byThe plasma proteins and their fractionationPreservation of Bacteria by LyophilizationThe plasma proteins and their fractionationThe plasma proteins and their fractionationThe Plasma Proteins and Their FractionationThe Use of Desiccated Plasma in UrologyÜber die entgiftende Therapie im KindesalterSHORT ABSTRACTS OF SOME OTHER ADVANCES IN PEDIATRICSON THE NATURE OF THE SACCHAROID FRACTION OF HUMAN BLOOD 1 August 1940Volume 14, Issue 2Page: 201-214KeywordsAntibodiesBlood plasmaHospital medicinePathology and laboratory medicineResearch laboratoriesSafetyTemperature ePublished: 1 December 2008 Issue Published: 1 August 1940 Copyright & PermissionsCopyright, 1940, by The American College of PhysiciansPDF downloadLoading ...