TREATMENT OF TOXOPLASMOSIS WITH PYRIMETHAMINE (DARAPRIM) AND TRIPLE SULFONAMIDE
Authors: R F WETTINGFELD, J ROWE, D E EYLES
Journal: Annals of Internal Medicine (1956)

Case Reports1 March 1956TREATMENT OF TOXOPLASMOSIS WITH PYRIMETHAMINE (DARAPRIM) AND TRIPLE SULFONAMIDER. F. WETTINGFELD, M.D., JOHN ROWE, M.D., DON E. EYLES, SC.D.R. F. WETTINGFELD, M.D., JOHN ROWE, M.D., DON E. EYLES, SC.D.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-44-3-557 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptIn the short space of 16 years since toxoplasmosis was first recognized as a disease in human beings, great strides have been made in delineating the various clinical syndromes, pathology and diagnosis of the disease. A dynamic interest in all the clinical and investigative aspects of this disease continues to reduce the gaps in our knowledge. Of the unsolved clinical problems in toxoplasmosis, the need for effective therapy is one of the greatest. While extensive laboratory investigation has disclosed agents of modest efficacy, the paucity of cases, especially those recognized sufficiently early, has made clinical corroboration difficult.We recently observed...Bibliography1. Strom J: Toxoplasmosis due to laboratory infection in two adults, Acta med. Scandinav. 139: 244, 1951. CrossrefMedlineGoogle Scholar2. SabinWarren ABJ: Therapeutic effect of the sulfonamides on infection by an intracellular protozoan (toxoplasma), abstract, J. Bact. 41: 80 (Jan.) 1941. Google Scholar3. Cross JB: Diasone and Promin as therapeutic agents in experimental toxoplasmosis, Proc. Soc. Exper. Biol. and Med. 76: 548 (Mar.) 1951. CrossrefMedlineGoogle Scholar4. Frenkel JK: Host, strain, and treatment variations as factors in the pathogenesis of toxoplasmosis, Am. J. Trop. Med. and Hyg. 2: 390 (May) 1953. CrossrefMedlineGoogle Scholar5. EylesColeman DEN: The relative activity of the common sulfonamides against experimental toxoplasmosis in the mouse, Am. J. Trop. Med. and Hyg. 2: 54 (Jan.) 1953. CrossrefMedlineGoogle Scholar6. Knapp W: Über chemotherapeutische Versuche am Erreger der Toxoplasmose, Med. Welt 20: 554, 1951. MedlineGoogle Scholar7. Eichenwald H: Experimental toxoplasmosis. II. Effect of sulfadiazine and antiserum on congenital toxoplasmosis in mice, Proc. Soc. Exper. Biol. and Med. 71: 45 (Jan.) 1949. CrossrefMedlineGoogle Scholar8. EylesColeman DEN: Tests of 2,4-diaminopyrimidines on toxoplasmosis, Pub. Health Rep. 67: 249 (Mar.) 1952. CrossrefMedlineGoogle Scholar9. Summers WA: The chemotherapeutic efficacy of Daraprim in experimental toxoplasmosis, Am. J. Trop. Med. and Hyg. 2: 1037 (Nov.) 1953. CrossrefMedlineGoogle Scholar10. EylesColeman DEN: Synergistic effect of sulfadiazine and Daraprim against experimental toxoplasmosis in the mouse, Antibiotics and Chemotherapy 3: 483 (May) 1953. Google Scholar11. Cross JB: Diasone, Avlosulfon and Sulphetrone as therapeutic agents in experimental toxoplasmosis, Am. J. Trop. Med. and Hyg. 1: 593 (June) 1952. CrossrefMedlineGoogle Scholar12. Summers WA: The effect of oral administration of aureomycin, sulfathiazole, sulfamerazine and 4,4′-diaminodiphenylsulfone on toxoplasmosis in mice, Am. J. Trop. Med. 29: 889, 1949. CrossrefMedlineGoogle Scholar13. BioccaNobrega EP: Sôbre a quimioterapia da toxoplasmose, Arq. de biol. 30: 63, 1946. Google Scholar14. AugustineWeinmanMcAllister DLDJ: Rapid and sterilizing effect of penicillin sodium in experimental relapsing fever infections and its ineffectiveness in the treatment of trypanosomiasis (Trypanosoma lewisi) and toxoplasmosis, Science 99: 19, 1944. CrossrefMedlineGoogle Scholar15. CrossAnigstein JBL: Chemotherapeutic study of experimental toxoplasmosis—preliminary report, Texas Rep. Biol. and Med. 6: 260, 1948. MedlineGoogle Scholar16. EylesColeman DEN: Antibiotics in the treatment of toxoplasmosis, Am. J. Trop. Med. and Hyg. 2: 64 (Jan.) 1953. CrossrefMedlineGoogle Scholar17. EylesColeman DEN: Notes on the treatment of acute experimental toxoplasmosis of the mouse with chlortetracycline and tetracycline, Antibiotics and Chemotherapy 4: 988 (Sept.) 1954. Google Scholar18. EylesColeman DEN: The antitoxoplasmic activity of puromycin, Antibiotics and Chemotherapy 4: 649 (June) 1954. Google Scholar19. McCowenCallenderLawlisBrandt MCMEJFMC: The effects of erythromycin (Ilotycin, Lilly) against certain parasitic organisms, Am. J. Trop. Med. and Hyg. 2: 212 (Mar.) 1953. CrossrefMedlineGoogle Scholar20. Sabin AB: Toxoplasmic encephalitis in children, J. A. M. A. 116: 801, 1941. CrossrefGoogle Scholar21. KassAndrusAdamsTurnerFeldman EHSBRFCHA: Toxoplasmosis in the human adult, Arch. Int. Med. 89: 759, 1952. CrossrefGoogle Scholar22. BrennanBrownWarrenVranian AJTJG: A syndrome characterized by generalized cutaneous eruption, chorioretinitis, and eosinophilia, probably due to toxoplasma infection, Am. J. Med. 7: 431 (Sept.) 1949. CrossrefMedlineGoogle Scholar23. Robinson P: A case of toxoplasmosis with recovery, Ann. pædiat. 168: 134 (Mar.) 1947. MedlineGoogle Scholar24. PriorColeDoctonSaslawChamberlain JACRFLSDM: Toxoplasmosis. IV. Report of three cases with particular reference to asymptomatic toxoplasma parasitemia in a young woman, Arch. Int. Med. 92: 314 (Sept.) 1953. CrossrefGoogle Scholar25. CorpeningStembridgeRigdon TNVDRH: Toxoplasmosis in Texas. Report of a case with autopsy, Texas State J. Med. 48: 469 (July) 1952. MedlineGoogle Scholar26. JacobsFairBickerton LJRJH: Adult ocular toxoplasmosis. Report of a parasitologically proved case, Arch. Ophth. 52: 63 (July) 1954. CrossrefMedlineGoogle Scholar27. SextonEylesDillman RCDERL: Adult toxoplasmosis, Am. J. Med. 14: 366 (Mar.) 1953. CrossrefMedlineGoogle Scholar28. MeiraNobregaAmato Neto APV: Toxoplasmosis adquirida (forma febril exantematica). Consideracoes clinicas sobre um caso observado em adulto e diagnosticado pelas provas serologicas. Efeito terapeutico do chloramphenicol, Rev. Hosp. clín. 7: 265, 1952. Google Scholar29. RyanHartCulliganGunkelJacobsCook RWWMJJRDLMK: Diagnosis and treatment of toxoplasmic uveitis, Tr. Am. Acad. Ophth. 58: 867 (Nov.-Dec.) 1954. MedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Memphis, Tennessee*Received for publication January 7, 1955.From the United States Public Health Service Hospital, Memphis, Tennessee, and the Laboratory of Tropical Diseases, National Microbiological Institute, National Institutes of Health, Public Health Service, 874 Union Avenue, Memphis, Tennessee. Requests for reprints should be addressed to the last institution. 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POSER, M.D.Pericarditis and myocarditis caused by toxoplasma: Report of a case and review of the literatureAcquired ToxoplasmosisThe relationship between structure and biological activity: Some fundamental aspects 1 March 1956Volume 44, Issue 3Page: 557-564KeywordsClinical pathologyInoculationMedical servicesPrevention, policy, and public healthPyrimethamineResearch laboratoriesSulfonamideToxoplasmosisTropical diseases ePublished: 1 December 2008 Issue Published: 1 March 1956 PDF downloadLoading ...