tbuckley/cabot-search huggingface dataset:
<i>BCR‐ABL1</i> kinase domain mutations: Methodology and clinical evaluation
Authors: Mary Alikian, Gareth Gerrard, Papagudi G. Subramanian, Katherine Mudge, Pierre Foskett, Jamshid Sorouri Khorashad, Ai Chiin Lim, David Marin, Dragana Milojkovic, Alistair Reid, Katy Rezvani, John Goldman, Jane Apperley, Letizia Foroni
Journal: American Journal of Hematology (2011)

The introduction of tyrosine kinase inhibitors (TKIs), starting with imatinib and followed by second and third generation TKIs, has significantly changed the clinical management of patients with chronic myeloid leukemia (CML). Despite their unprecedented clinical success, a proportion of patients fail to achieve complete cytogenetic remission by 12 months of treatment (primary resistance) while others experience progressive resistance after an initial response (secondary resistance). BCR-ABL1 kinase domain (KD) mutations have been detected in a proportion of patients at the time of treatment failure, and therefore their identification and monitoring plays an important role in therapeutic decisions particularly when switching TKIs. When monitoring KD mutations in a clinical laboratory, the choice of method should take into account turnaround time, cost, sensitivity, specificity, and ability to accurately quantify the size of the mutant clone. In this article, we describe in a "manual" style the methods most widely used in our laboratory to monitor KD mutations in patients with CML including direct sequencing, D-HPLC, and pyrosequencing. Advantages, disadvantages, interpretation of results, and their clinical applications are reviewed for each method.
Diagnosing Pinochet syndrome
Authors: Mary E Black
Journal: BMJ (2006)

<h3>Objective</h3> COVID-19 infection is suggested as one of the causes for hydrocephalus (HCP) of unknown etiology. COVID-19 infection may present with a range of neurologic symptoms given viral neurotropic and neuroinvasive properties. Postinfectious HCP is a severe complication as a potential sequela of COVID-19 infection. <h3>Methods</h3> We identified a patient with a history of recent COVID-19 infection who presented with chronic progressive headaches with nausea, vomiting, and blurry vision over 2 weeks. <h3>Results</h3> Neurologic examination showed bilateral papilledema. The head CT scan showed tetraventricular enlargement and marked fourth ventricular dilation. Cine MRI showed fourth ventricular turbulent CSF flow. The patient underwent external ventricular drain placement and exploratory suboccipital craniotomy, which revealed a subarachnoid web that was microsurgically resected. Reconstituted CSF flow resolved the patient9s symptoms and prevented complications. <h3>Discussion</h3> Fourth ventricular outlet obstruction is a rare cause of tetraventricular HCP. In most cases, it is associated with a history of inflammatory conditions or hemorrhage. In our case, a history of recent COVID-19 infection and normal imaging before COVID-19 make COVID-19 the most probable explanation for HCP. We suggest considering COVID-19 infection in the differential diagnosis of HCP of unclear etiology.
Plasma Protein Carbonyls and Breast Cancer Risk in Sisters Discordant for Breast Cancer from the New York Site of the Breast Cancer Family Registry
Authors: Jennifer Zipprich, Mary Beth Terry, Yuyan Liao, Meenakshi Agrawal, Irina Gurvich, Ruby Senie, Regina M. Santella
Journal: Cancer Research (2009)

Abstract Reactive oxygen species are important in the pathogenesis of many diseases, including breast cancer. Several population-based case-control studies have shown that various biomarkers of oxidative stress are associated with an increase in breast cancer risk. We selected sisters discordant for breast cancer (n = 645) from the New York site of the Breast Cancer Family Registry to explore factors that contribute to variation in plasma protein carbonyls, and to determine whether this biomarker is associated with an increase in breast cancer risk among those with a family history. Late age at menarche, hormone replacement therapy use, and Hispanic race were significantly associated with lower plasma protein carbonyl levels in unaffected sisters. Plasma protein carbonyls were associated with an increase in breast cancer risk [Q2 odds ratio (OR), 1.4; 95% confidence interval (CI), 0.8–2.7; Q3 OR, 2.4; 95% CI, 1.1–4.9; Q4 OR, 1.9; 95% CI, 0.8–4.2], although not in a dose-dependent manner. These data suggest that oxidative damage is a risk factor for breast cancer in high-risk women. [Cancer Res 2009;69(7):2966–72]
The role of Sirt1 in renal rejuvenation and resistance to stress
Authors: Karl A. Nath
Journal: Journal of Clinical Investigation (2010)

This issue of the JCI includes studies demonstrating that sirtuin 1 (Sirt1), a NAD+-dependent deacetylase, slows renal senescence and safeguards cells in the renal medulla. Kume et al. demonstrated that caloric restriction protected the aging kidney by preserving renal Sirt1 expression, the latter deacetylating forkhead box O3a (FOXO3a), inducing Bnip 3, and promoting mitochondrial autophagy. Sirt1 expression, as shown by He et al., enabled interstitial cells to withstand the oxidizing medullary environment and exerted antiapoptotic and antifibrotic effects in the obstructed kidney. Sirt1 is thus an important participant in renal cytoprotective responses to aging and stress.
Evaluating Clinical Management Decisions by Recent Graduates in the Era of High-Value, Cost-Conscious Care—Reply
Authors: Brenda E. Sirovich, Eric S. Holmboe, Rebecca S. Lipner
Journal: JAMA Internal Medicine (2015)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Internal Medicine HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Internal Medicine journal
Expression and Mutational Status of c-kit in Thymic Epithelial Tumors
Authors: Iacopo Petrini, Paolo A. Zucali, Hye Seung Lee, Marbin A. Pineda, Paul S. Meltzer, Beatriz Walter-Rodriguez, Massimo Roncalli, Armando Santoro, Yisong Wang, Giuseppe Giaccone
Journal: Journal of Thoracic Oncology (2010)
Nutritively Sweetened Beverage Consumption and Obesity
Authors: David B. Allison, Richard D. Mattes
Journal: JAMA (2009)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Contamination of the Blood Supply in the 1980s and 1990s
Authors: Ann Pozen
Journal: Annals of Internal Medicine (2003)

Letters7 January 2003Contamination of the Blood Supply in the 1980s and 1990sAnn Pozen, PsyDAnn Pozen, PsyDNational Association for Victims of Transfusion-Acquired AIDS, Bethesda, MD 20817 (Pozen)Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-138-1-200301070-00027 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:Weinberg and colleagues (1) correctly state that the United States was one of the last developed countries to compensate people with hemophilia who contracted HIV infection from contaminated blood products. The authors fail to mention that while the compensation policies of other countries include people who became infected with HIV from blood transfusions, the United States has provided no compensation to such persons. In addition, state laws protecting blood banks from liability have prevented people with transfusion-acquired HIV infection from filing suit.Weinberg and colleagues' Table 3 indicates that the United States has compensated people infected with ...Reference1. Weinberg PD, Hounshell J, Sherman LA, Godwin J, Ali S, Tomori C, . Legal, financial, and public health consequences of HIV contamination of blood and blood products in the 1980s and 1990s. Ann Intern Med. 2002;136:312-9. [PMID: 11848729] LinkGoogle Scholar Author, Article, and Disclosure InformationAffiliations: National Association for Victims of Transfusion-Acquired AIDS, Bethesda, MD 20817 (Pozen) PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoLegal, Financial, and Public Health Consequences of HIV Contamination of Blood and Blood Products in the 1980s and 1990s Peter D. Weinberg , Jennie Hounshell , Laurence A. Sherman , John Godwin , Shirin Ali , Cecilia Tomori , and Charles L. Bennett Metrics 7 January 2003Volume 138, Issue 1Page: 78-79KeywordsBloodBlood banksBlood transfusionHIVHIV infectionsHemophilia ePublished: 7 January 2003 Issue Published: 7 January 2003 CopyrightCopyright © 2003 by American College of Physicians. All Rights Reserved.PDF DownloadLoading ...
Montelukast attenuates the airway response to hypertonic saline in moderate-to-severe COPD
Authors: I.E. Zühlke, F. Kanniess, K. Richter, D. Nielsen-Gode, S. Böhme, R.A. Jörres, H. Magnussen
Journal: European Respiratory Journal (2003)

This study assessed the effect of the leukotriene receptor antagonist montelukast on hypertonic saline-induced airway obstruction. A total of 29 patients with chronic obstructive pulmonary disease (forced expiratory volume in one second (FEV 1 ), 42±4% predicted) received either 10 mg montelukast and 3 h later placebo via metered-dose inhaler (MDI) (M), or placebo and 3h later 200 µg salbutamol (S), or two doses of placebo (P), in a randomised order. Patients inhaled salbutamol 1 h after MDI and the challenge was performed 15 min later (3% saline, 5 min). Data are given as per cent changes versus baseline. Compared to P, S caused significant bronchodilation in FEV 1 (7.3%) and forced inspiratory volume in one second (FIV 1 ) (4.5%), and M in FIV 1 (1.5%). The saline-induced fall in FEV 1 was lower after M (−5.8%), compared with S (−10.3%) and P (−13.1%). FEV 1 (11.3%) and FIV 1 (7.6%) was improved over baseline after recovery by M but not P and S. Recovery times regarding FEV 1 (8.5 min) and FIV 1 (15.2 min) were shortest after M, respective values for S being 16.8 and 20.4 min, and for P 15.9 and 21.2 min. Effects were strongest in patients with low baseline FEV 1 and/or inhaled corticosteroids. Data from this study indicate beneficial effects of montelukast on hypertonic saline-induced airway responses in patients with chronic obstructive pulmonary disease, particularly those with severe disease. The major effect was an accelerated recovery leading to values above baseline.
Mixing Medicine and Morality
Authors: L. J. Witts
Journal: BMJ (1967)

MEDIBALOURNALthe clinical applications (though these are not neglected) but also in generous measure the fundamentals of these sciences.Thus, the first chapter deals at some length with the basic physiology of the heart, the mechanism of the coronary circulation, the control of blood pressure, the methods of assessing heart performance, and the inter- pretation of electrocardiographs.This is followed by sections dealing with the distur- bances of function resulting from heart diseases and those brought about by surgical attack on the heart.Other chapters deal similarly with the physiology of the respira- tory, alimentary, urinary, endocrine, and nervous systems, and with related questions of applied physiology.There are also chap- ters on genetics in relation to clinical medi- cine, on allergy and immunity, and on the physical and chemical basis of cancer chemo- therapy.Naturally, the fluid balance receives full attention, and there are good accounts of the physiology of haematopoiesis, of the metabolism of iron, of the serum proteins, and of defects of haemostasis.Altogether the book contains nearly a hun- dred sections by 130 contributors, the majority British surgeons, with some physi- cians and laboratory workers, and a small but distinguished group of surgeons from the United States and Canada.The writing is vigorous, succinct, and lucid and the general standard of presentation is uniformly high.
TO-DAY'S CRUSADE AGAINST CONSUMPTION.
Authors: ALBERT PHILIP FRANCINE
Journal: JAMA (1905)

Prophylaxis in pulmonary tuberculosis, that is, its prevention, is of such general interest and of such vital importance that the presentation of this subject in a public address needs no apology. People everywhere are alive to the preventable character of this disease, and never before has the interest in this phase of the subject been more widespread. Before taking up the subject proper of this paper, however, I wish to present some interesting figures from the United States Census Reports 11 and 12, and from certain German reports. In the year 1890, 102,199 people died of consumption in the United States; a proportion of over 12,000 per 100,000 deaths. In 1900, 111,059 people died of consumption; a proportion of over 10,000 per 100,000 deaths. It will be seen that over a hundred thousand lives are lost a year through this dread disease; or, to put it a little differently, one
Polyunsaturated fatty acids and colchicine in multiple sclerosis.
Authors: D F Horrobin, T Botez, M I Botez
Journal: BMJ (1979)

capsid antigen.The IgM titre was screened routinely at 1/8 but no further dilutions were assayed.The discrepancy in the titres re- ported from Manchester and Colindale on roughly contemporaneous samples can only be attributed to methodological differences.Antibodies to cytomegalovirus were de- tected in the laboratory of Professor Harold Stern, St George's Hospital Medical School, using complement fixation as stated in our article.Numerous attempts were made to isolate this virus from the patient's urine but without success.Because of limitations of space, we could only summarise the serological data in our article and we could not fully discuss the diagnostic possibilities.We agree that one cannot be dogmatic about the nature of this patient's illness.It is our belief that the most likely explanation is that she had a primary infection with EB virus to which she was unable to make an adequate immunological response.Indeed, the antibody titres to cyto- megalovirus may be attributable to cross- reaction of antibody between this virus and EB virus.'However, we agree that we cannot exclude the possibility that this patient had a double infection with both viruses and that the impaired response to EB virus reflects the immunosuppression induced by cytomegalovirus.
ADVERSE PLAQUE CHARACTERISTICS WITHIN NON-OBSTRUCTIVE AND INTERMEDIATE LESIONS BY CORONARY CT ANGIOGRAPHY ARE ASSOCIATED WITH LESION-SPECIFIC ISCHEMIA BY NONINVASIVE FRACTIONAL FLOW RESERVE DERIVED FROM CT: RESULTS FROM THE PROSPECTIVE MULTICENTER DEFACTO (DIAGNOSTIC ACCURACY OF FRACTIONAL FLOW RESERVE FROM ANATOMIC CT ANGIOGRAPHY) STUDY
Authors: Hyung Bok Park, Ryo Nakazato, Matthew Budoff, Jonathon Leipsic, Yuka Otaki, Daniel Berman, James Min
Journal: Journal of the American College of Cardiology (2013)
DIAGNOSIS and TREATMENT of SPASMODIC STRICTURE of the OESOPHAGUS
Authors: J. C. Russel
Journal: BMJ (1898)

The whistle was made of tin, and measured 4l3 inch in diameter.CASE II.Coin in iE3ophagus for Three Months.-R.E., a girl, aged 13, was admitted into hospital on February iith, com- plaining of pain and tenderness between the scapulie, with a history of having swallowed a penny three months previously.Three months previously she swallowed a penny accident- ally; it seemed to " stick" in her throat.She had been under medical treatment since for pain in the back.There was no difficulty whatever in swallowing either liquids or solids, the only symptoms complained o1 being pain and tenderness over the eighth dorsal spine.A skiagraph taken on Feb- ruary ioth revealed the penny situated just behind the 1~~~~F ig.2.-Skiagraph of penny in cesophagus.
Studies of the Hypothalamus and the Pitultary Gland: With Special Reference to the Effects of Transection of the Pituitary Stalk
Authors: William C. Gibson
Journal: JAMA (1976)

In a difficult field, the present volume offers a superb summary of the findings of two senior researchers who worked for 25 years at the Nuffield Institute for Medical Research at Oxford, and in the Department of Neuropathology at the University of London. The illustrations alone could carry the story, so exceptional are they. The work has the additional merit of dealing with normal and pathological states in a wide variety of animals as well as in humans. The techniques used to trace the two groups of portal vessels (not a single system as we once thought) are highly refined in the hands of two veterans schooled in the intricacies of vascular shunts. The cytological changes following interruption of the stalk are well documented, but a surprising thing is the wealth of regenerating nerve fibers to be found some time after the hypthalamo-hypophysial tract has been cut. A good bibliography
Characterization of a new monoclonal antibody to rat macrophages and Kupffer cells
Authors: Henry C. Bodenheimer, Ronald A. Faris, Colette Charland, Douglas C. Hixson
Journal: Hepatology (1988)

We have characterized the cell and tissue binding specificity of a newly generated monoclonal antibody, Mab Ku-1, which shows selective reactivity with rat macrophages and Kupffer cells. The hybridoma secreting Mab Ku-1 was constructed by fusion of 8653 myeloma cells with spleen cells isolated from a mouse immunized with nonparenchymal liver cells coated with antihepatocyte antibodies. When binding was assessed by indirect immunofluorescence on frozen sections from normal liver tissue, Mab Ku-1 showed strong reactivity with Kupffer cells but was unreactive with hepatocytes, endothelial cells, bile ducts or lymphocytes. Both resident and activated macrophages bound Mab Ku-1. Reactivity in other tissues was compatible with specificity for macrophages. In the gut, scattered cells in the lamina propria were positive, whereas epithelial cells were negative. Individual cells in the lung were reactive. In the spleen, cells in the red pulp peripheral to germinal centers bound antibody. Reactivity of Mab Ku-1 to isolated Kupffer cells correlated with endogenous peroxidase activity. Sodium dodecyl sulfate-polyacrylamide gel electrophoresis analysis of components immunoprecipitated by Mab Ku-1 from detergent lysates of Kupffer cells biosynthetically labeled with 35 S-cysteine and 35 S-methionine demonstrated that the reactive antigen was a peptide with an apparent molecular weight of 107 kD. This rat macrophage-reactive monoclonal antibody is a useful marker for identification of macrophage populations in tissue as well as in isolated cell populations.
Paraneoplastic pemphigus. A report of two cases associated with chronic B-cell lymphocytic leukaemia
Authors: A.V. Marzano, A. Grammatica, E. Cozzani, M. Terracina, E. Berti
Journal: British Journal of Dermatology (2001)

Paraneoplastic pemphigus (PNP) is an autoimmune blistering and erosive mucocutaneous disease associated with neoplasia. Clinical manifestations are polymorphous, and include erythema, bullae, erythema multiforme-like lesions and severe mucous membrane involvement. PNP manifesting as lichenoid dermatitis has recently been observed. We describe two Italian men with fatal PNP featuring typical PNP autoantigens associated with chronic B-cell lymphocytic leukaemia. The first patient presented with an extensive blistering eruption, several erythema multiforme-like lesions and severe mucosal involvement. The second patient presented with a lichenoid dermatitis, then developed bullae, and died with an erythrodermic and exfoliative dermatosis resembling pemphigus foliaceus. Our patients represent two Italian cases of well-documented PNP. In patient 2, the sequence of clinical presentations was unique, and strongly supports the hypothesis of epitope spreading through chronic lichenoid inflammation of the dermo-epidermal junction exposing new self antigens, leading to the humoral response characteristic of PNP.
Immunohistochemical Differentiation of Hepatitis D Virus Genotypes
Authors: Sheng-Chieh Hsu, Wan-Jr Syu, Ling-Tan Ting, Jaw-Ching Wu
Journal: Hepatology (2000)

Determination of hepatitis D virus (HDV) genotypes is epidemiologically and clinically important. Phylogenic analysis based on sequencing analysis of multiple HDV strains isolated from sera of patients is not convenient for mass screening in routine laboratories. This study was designed to develop genotype-specific antibodies against hepatitis delta antigen (HDAg) and to apply these antibodies for immunohistochemical differentiation of HDV genotypes in formalin-fixed, paraffin-embedded liver biopsies of patients. Divergence in the carboxyl-terminal 19 amino acids of the large HDAg between genotypes I and II is more than 70%. Peptides covering these residues were conjugated to keyhole limpet hemocyanin and were used for immunization. The generated antibodies were confirmed for their specificity by binding to type-specific HDAgs expressed in DNA-transfected Huh-7 hepatoma cells. Liver biopsies from 6 patients who had dominant genotype I HDV and 33 patients who had dominant genotype II HDV in sera were stained with these antibodies. The accuracy for these antibodies was 94.9%, and the agreement between dominant HDV genotypes in serum and dominant hepatic HDV genotypes based on HDAg staining was nearly perfect (kappa = 0.83). In summary, the carboxyl-terminal 19 amino acids of the large HDAg can be used as immunogens to generate genotype-specific antibodies. These antibodies were proven to be useful in immunohistochemical differentiation of HDV genotypes in liver biopsies.