tbuckley/cabot-search huggingface dataset:
47 CD39 EXPRESSION ON A SUBSET OF BONE MARROW DERIVED CD133+CD45+ STEM CELLS FACILITATES THEIR MOBILIZATION AND PROMOTES LIVER REGENERATION
Authors: M. Schmelzle, C. Duhme, W. Junger, S.D. Salhanick, Y. Chen, E. Csizmadia, M. Nowak, J. Schulte am Esch, W.T. Knoefel, S.C. Robson
Journal: Journal of Hepatology (2011)
Therapeutic opportunities for cell cycle re-entry and cardiac regeneration
Authors: K REGULA, M RZESZUTEK, D BAETZ, C SENEVIRATNE, L KIRSHENBAUM
Journal: Cardiovascular Research (2004)

Over the last two decades, considerable effort has been made to better understand putative regulators and molecular switches that govern the cell cycle in attempts to reactivate cell cycle progression of cardiac muscle. Rapid advancements on the field of stem cycle biology including evidence of cardiac progenitors within the adult myocardium itself and reports of cardiomyocyte DNA synthesis, which each suggest that the adult myocardium may in fact have the capacity for de novo myocyte regeneration. Augmenting cardiomyocyte number by targeting specific cell cycle regulatory genes or by stimulating cardiac progenitor cells to differentiate into cardiac muscle may be of therapeutic value in repopulating the adult myocardium with functionally active cells in patients with end-stage heart failure. Advancements in the area of cardiomyocyte cell cycle control and regeneration and their therapeutic potential are discussed.
Opposes Making Dentists Semi-Physicians.
Authors: H. E. Dunlop
Journal: JAMA (1902)

Chicago, Ill., June 21, 1902. <h3>To the Editor:</h3> —Dr. Peck's plan to teach physical diagnosis to dentists seems to me a highly superfluous one. To gradually make the 40,000 dentists in this country semi-doctors is to add to the already much overcrowded medical profession an additional burden. The doctor seems to forget that a man who is not licensed to practice medicine has no business to do so, and if making a physical diagnosis and then advising the patient along such lines is not practice of medicine, what is it? He forgets, too, that while the dentist in such instances gets remunerated for his part of the work the doctor is thrown out of his legitimate fee. Nearly every patient who goes to a dentist is the patient of some physician, and it would be the height of discourtesy, to say nothing of the lack of necessity in 99/100 of
OC-067 Enhanced Perception Of Proximal Gastro-oesophageal Reflux: Impaired Mucosal Integrity Or Distinct Sensory Innervation?
Authors: P Woodland, C Lee, R Aktar, E Mthunzi, LA Blackshaw, SL Preston, D Sifrim
Journal: Gut (2014)

<h3>Introduction</h3> In patients with GORD, including refractory disease, reflux events reaching the proximal oesophagus are more likely to be perceived than those only reaching the distal oesophagus. There is also experimental data suggesting an increased sensitivity of the proximal oesophagus relative to the distal. As such, the proximal oesophagus is likely to be highly significant in the pathogenesis of GORD symptoms. Reasons for this proximal oesophageal sensitivity are not clear, but may include reflux volume, impairment in mucosal integrity or changes in sensory innervation. It has recently been shown that distal mucosal integrity (its ability to perform a protective barrier function) is more vulnerable to acid exposure in GORD than in controls. The integrity of the proximal oesophagus has not been tested. To our knowledge, there are no studies evaluating mucosal afferent innervation of the distal and proximal oesophagus. We <b>aimed</b> to compare mucosal integrity and afferent nerve distribution in the proximal and distal oesophagus in patients with heartburn without oesophagitis. <h3>Methods</h3> In 23 patients with heartburn and 10 healthy volunteers baseline proximal and distal oesophageal impedance was measured <i>in vivo</i>. Oesophageal mucosal biopsies from the distal and proximal oesophagus were taken and baseline transepithelial electrical resistance (TER) was measured in Ussing chambers. Biopsies were examined immunohistochemically for presence and location of calcitonin gene-related peptide (CGRP) immunoreactive nerve fibres. <h3>Results</h3> Baseline impedance was higher in the proximal than in the distal oesophagus in healthy volunteers (2935 ± 204 Ω vs. 2234 ± 290 Ω, p &lt; 0.05) and in patients (2949 ± 183Ω vs.1945 ± 235Ω, p &lt; 0.001). However, baseline TER was not significantly different between proximal and distal oesophagus, or between patients with heartburn and healthy volunteers. Mucosal CGRP-immunoreactive nerves were located more superficially in the proximal oesophagus compared to the distal oesophagus in healthy controls (12.3 ± 0.9 vs. 23.8 ± 1.2 cells from lumen, p &lt; 0.001) and in patients (5.7 ± 0.7 vs. 22.2 ± 2.7 cells from lumen, p &lt; 0.0001). Moreover, these nerves were located closer to the lumen in patients with heartburn compared to asymptomatic controls (5.7 ± 0.7 vs. 12.3 ± 0.9, p &lt; 0.001). <h3>Conclusion</h3> The baseline mucosal integrity of the proximal oesophagus is not more impaired than that of the distal, nor is it more impaired in patients with heartburn symptoms versus healthy controls. Increased sensitivity of the proximal oesophagus in GORD may instead be associated with a more superficial location of mucosal afferent nerves. Topical protection of the proximal oesophageal mucosa is a potential treatment strategy to reduce this sensitivity. <h3>Disclosure of Interest</h3> None Declared.
THE REPLACEMENT OF STREPTOMYCIN-RESISTANT COLIFORM BACTERIA IN THE STOOLS BY STREPTOMYCIN-SENSITIVE VARIANTS DURING AND FOLLOWING THE CESSATION OF STREPTOMYCIN THERAPY 12
Authors: Morton Hamburger, Jerome R. Berman
Journal: Journal of Clinical Investigation (1950)

Thouglh the appearanice of streptomycini-resist- ant bacteria during the course of streptomycin therapy has been abundantly demonstrated (1), less attention has been paid to the ultimate fate of these resistant formiis.Our attention was drawn to this problem during an investigation of the development of streptomycin-resistant variants among the normally commllensal but potentially pathogenic flora of the body.Though streptomycin-resistant coliformii bacilli are almost uni- formly absent from the stools of human beings who have not receive(d streptomycin.they frequently appear during the intramiuscular administration of streptomycin for certain types of tuber- culosis (2) and during its oral a(Idmiinistration for various purposes.Our investigationis lhave shown that in mnany cases the normally "senisitive" coliformiis were replace(d during treatmenit by resistant strains of the same species.However, when streptomycin was discontinued, and in special instances, even before the (Irug was (lisconitinued, sensitive coliforms began to reappear an(d finally crow(le(l out the resistant variants altogetlher.It is the purpose of this paper to presenit the dlata dealing with this replacemiient of resistant by sensitive strains. AI ET H ODS A. Selection of caIsesThe 11 patients studied were hospitalized oni the medi- cal wards of the Cincinnati General Hospital.They in- cluded two cases of miliary tuberculosis, seven cases of tuberculous peritonitis, and two cases of typhoid fever.
Review overemphasises benefits and downplays serious harms
Authors: V. Musini, B. Mintzes, A. Tejani, J. M. Wright
Journal: BMJ (2012)

We recently conducted a systematic review of bisphosphonates in postmenopausal women with osteoporosis. Our critical appraisal of evidence from 33 randomised controlled trials (25 375 women) of at least one year’s duration reached different conclusions from those of Poole and Compston.1 2

The goal of treatment is prevention of fragility fractures. Effects on bone mineral …
Structure-activity relationships among dithiocarbamate antidotes for acute cadmium chloride intoxication.
Authors: S G Jones, M M Jones
Journal: Environmental Health Perspectives (1984)

Eight sodium dithiocarbamates (NaS2CNR1R2) have been examined as antidotes for acute cadmium intoxication. While all of them possess an ability to increase survival when given to mice 2 hr after a lethal (greater than 99%) intraperitoneal injection of 10 mg/kg of CdCl2 X 2.5H2O, their effects on the organ distribution of cadmium vary considerably. It has been possible to show that the accumulation of cadmium in the brain and kidney as well as the survival rates can be correlated with a numerical measure of the polarity of the groups R1 and R2. Each factor has a different dependence on the polarity, but it is possible to construct a composite factor for antidotal efficacy which incorporates survival rate, brain cadmium levels and kidney cadmium levels. The factor constructed here exhibits an optimal value approximately in the middle of the polarity range studied. Compounds which have R1 = -CH2CH1OH and R2 = -CH2CH2OH, or -CH3 or -C2H5 appear to be the most effective antidotes of the compounds examined.
SOCIAL SCIENCE PROBLEMS OF INEBRIETY.Read before the Social Science Association, Saratoga, N. Y.
Authors: T. D. CROTHERS
Journal: JAMA (1892)

Notwithstanding all the advances of civilization and intelligence, and the increasing temperance agitation, and effort, the drink evil, or inebriety, is one of the most threatening ominous perils to all social progress and development of to-day. Some idea of its extent may be obtained from the following statistics. In 1890 over half a million persons were arrested in this country charged with being drunk and disorderly, crazed from the effects of alcohol. Nearly twenty per cent, had committed crime of petty character while under the influence of spirits. These facts furnish some approximate estimate of the extent of inebriety in this country. It is reasonable to infer that if half a million inebriates have come under police surveillance in one year, at least a third of this number using alcohol to excess, have escaped legal notice. The statement that there are fully a million persons in this country who are,
Proposed Mental Health Bill may breach human rights, says Law Society
Authors: Clare Dyer
Journal: BMJ (2004)

Proposals in the draft Mental Health Bill to forcibly treat people with mental health problems in the community could breach patients' human rights, the Law Society warned last week.

The warning came as the society, representing solicitors in England and Wales, gave evidence to the parliamentary committee scrutinising the draft bill.

The bill would allow compulsory treatment to be imposed on patients living in the community as well as those in hospital.

Mental health staff could also impose conditions banning patients from engaging in “specified conduct,” such …
Uncommon Presentations of Non-Hodgkin’s Lymphoma
Authors: Mario Chenal, Hernan Molina, Vinicio Mendez, John Poole, Carlos Parellada
Journal: Journal of Clinical Oncology (2003)

Article Tools DIAGNOSIS IN ONCOLOGY Article Tools OPTIONS & TOOLS Export Citation Track Citation Add To Favorites Rights & Permissions COMPANION ARTICLES No companion articles ARTICLE CITATION DOI: 10.1200/JCO.2003.03.014 Journal of Clinical Oncology - published online before print September 21, 2016 PMID: 12560451 Uncommon Presentations of Non-Hodgkin’s Lymphoma Case 2. Non-Hodgkin’s Lymphoma of the Ileocecal Region Mario ChenalxMario ChenalSearch for articles by this author , Hernan MolinaxHernan MolinaSearch for articles by this author , Vinicio MendezxVinicio MendezSearch for articles by this author , John PoolexJohn PooleSearch for articles by this author , Carlos ParelladaxCarlos ParelladaSearch for articles by this author Show More Hospital General San Juan de Dios, Ciudad Guatemala, Guatemala https://doi.org/10.1200/JCO.2003.03.014 First Page Full Text PDF Figures and Tables © 2003 by American Society of Clinical Oncology
A Health Policy Agenda Proposal for Including the Poor
Authors: James R. Tallon
Journal: JAMA (1989)

Medicaid, the nation's major program to provide health care to low-income persons, is failing to meet the health care needs of the poor. Even though the number of poor persons without access to health insurance has grown over the past decade, 11 million persons with incomes below the federal poverty level were without any health insurance in 1988, and over 50% of the poor did not qualify for Medicaid. Although a patchwork of charity care and publicly funded health provision systems is available to some individuals in some communities, this incomplete system does not ensure access to comprehensive and consistent care for all who need it. A 1986 survey discovered that 19 million Americans encountered difficulty in obtaining health care because of financial reasons, and an estimated 1 million persons were denied care because they were unable to afford it. The failure of the program to provide comprehensive access for
Bone loss in patients treated with pulses of methylprednisolone is not negligible: a short term prospective observational study
Authors: G Haugeberg
Journal: Annals of the Rheumatic Diseases (2004)

<b>Objective:</b> To examine the influence of intravenous pulsed methylprednisolone (MP) on bone mass. <b>Methods:</b> 38 patients (30 women) with various rheumatic disorders requiring intravenous MP pulse treatment were examined at baseline and after 6 months with dual energy <i>x </i>ray absorptiometry (DXA), measuring hip and lumbar spine bone mineral density (BMD). Demographic and clinical data were collected. <b>Results:</b> Demographics showed: mean (SD) age 48.4 (16.3) years, body mass index 24.9 (5.1) kg/m<sup>2</sup>, and median (range) disease duration 3.2 (0.1–40.0) years. During follow up patients received a mean cumulative MP dose of 3.0 (1.6) g given as 5.7 (2.0) pulses over a median period of 5.7 (2.3–33.7) months. 34/38 (89%) patients were also pulsed with cyclophosphamide, 20 (53%) were taking oral corticosteroids, and 8 (21%) were using either bisphosphonates or oestrogen. At the end of the study mean BMD was reduced by −2.2% at the femoral neck, −1.1% at the total hip, and −1.0% at the spine L2-4. In subgroups BMD increased in patients treated with bisphosphonates or oestrogen (femoral neck +1.6%, total hip +3.2%, spine L2-4 +4.5%), whereas BMD decreased at all sites in patients not treated with antirersorptive treatment, both for users (femoral neck −4.4%, total hip −2.4%, spine L2-4 –2.1%) and non-users of concomitant oral prednisolone (femoral neck −1.7%, total hip –1.9%, spine L2-4 –2.6%). <b>Conclusion:</b> Treatment with intravenous pulses of MP leads to a high rate of bone loss. Prevention of bone loss in these patients with bisphosphonates and oestrogens should be considered.
Controlled Trial of Inhaled Budesonide in Patients with Cystic Fibrosis and Chronic Bronchopulmonary<i>Pseudomonas aeruginosa</i>Infection
Authors: HANS BISGAARD, SVEND STENVANG PEDERSEN, KIM GJERUM NIELSEN, MARIANNE SKOV, EVA MOSFELDT LAURSEN, GITTE KRONBORG, CLAUS MICHAEL REIMERT, NIELS H ØIBY, CHRISTIAN KOCH
Journal: American Journal of Respiratory and Critical Care Medicine (1997)

The efficacy and safety of anti-inflammatory treatment with inhaled glucocorticosteroids in patients with cystic fibrosis (CF) and complicating chronic Pseudomonas aeruginosa (P.a.) lung infection was studied in a placebo-controlled, parallel, double-blind single center trial. Active treatment consisted of budesonide dry powder, 800 μ g twice daily, delivered from a Turbuhaler®. The study period covered two successive 3-mo intervals between elective courses of intravenous anti-Pseudomonas antibiotics. Fifty-five patients entered the study, with a mean age of 20 yr and a mean FEV1 of 63% of predicted. Analysis of all patients entered, irrespective of trial adherence ("intention to treat"), showed a decrease in FEV1 in the first period of − 0.032 L in patients on budesonide versus − 0.187 L in patients on placebo (p = 0.08). The corresponding figures for the patients adhering to the protocol during the first period were − 0.017 L versus − 0.198 L (p < 0.05, confidence interval of the difference: − 0.035 to + 0.327 L). For all patients entered, as well as for patients adhering to the trial, there was always a trend in favor of budesonide, as judged by changes in FEV1 and FVC in both 3-mo periods. None of the patients had asthma, but the patients on budesonide had a mean improvement in histamine reactivity of + 1.15 dose steps over the entire 6-mo period, as opposed to + 0.017 dose steps in patients on placebo (p < 0.05). There was also a significant (p = 0.01) correlation between pre-trial histamine reactivity and the change in FEV1 in the first period in patients on budesonide. We conclude that inhaled glucocorticosteroids can be of short-term benefit in patients with CF and chronic P.a. infection and that those patients most likely to benefit from this treatment are patients with hyperreactive airways. Prolonged studies in larger number of patients are necessary to determine the long-term efficacy of this treatment.
TRIORTHOCRESYL PHOSPHATE AND POLYNEURITIS
Authors: M. I. Smith
Journal: JAMA (1934)

<h3>To the Editor:—</h3> In a paper on Neuritis by Cobb and Coggeshall inThe Journal, November 24, the subject of triorthocresyl phosphate polyneuritis is discussed. The following references are cited by the authors for this type of neuritis on page 1615: Vonderahe, A. R.: Pathologic Changes in Paralysis Caused by Drinking Jamaica Ginger, Arch. Neurol. &amp; Psychiat. 25:29 (Jan.) 1931. Merritt, H. H., and Moore, M.: New England J. Med. 203:4 (July) 1930. Mella, Hugo: A Preliminary Report on the Treatment of Paralysis Agitans, Arch. Neurol. &amp; Psychiat. 7: 137 (Jan.) 1922. Smith, M. I., and Elvove, Elias: Pub. Health Rep. 45: 1703 (July 25) 1930. The reference to Mella's paper is obviously an oversight or typographic error, for this report deals with arsenic and not triorthocresyl phosphate, which, so far as I have been able to ascertain, was not known to medical science until 1930. Neither Vonderahe nor Merritt
THE PREVENTION OF TYPHOID FEVER.
Authors: RUFUS I. COLE
Journal: JAMA (1904)

To infected water have been attributed the approximately 200,000 cases of typhoid fever which occur each year in this country. But it is the old story of the innocent blamed while the guilty escape. It required almost three centuries of fighting, from Francisco Redi to Pasteur, before the theory of spontaneous generation could be overthrown. To-day, though the proof is certain that only from one case of typhoid is another begotten, we close our eyes to the truth, and go on acting as though water were the source of all typhoid infection. To stamp out typhoid fever, in the absence of any specific treatment, requires (1) the recognition of all cases, and (2) the destruction of all typhoid bacilli as they leave the patient. The process need not even be so complete;<i>most</i>may be substituted for<i>all</i>. Though the water supply contain as much sewage as Chicago River, or
Incomplete Border Sign of Extrapleural Masses
Authors: Richard Ellis
Journal: JAMA (1977)

WHEN an extrapleural mass is seen partially<i>en face</i>, it may simulate a pulmonary parenchymal lesion. However, the presence of an incomplete border is a clue to the true nature of the mass.<sup>1</sup> <h3>Report of a Case</h3> A routine chest x-ray film (posteroanterior view) of a 21-year-old man showed a large lesion in the left midlung field with an incomplete border sign laterally, indicating an extrapleural mass (Fig 1). The oblique view showed typical signs of an extrapleural mass (Fig 2). The presence of destructive changes in the fourth rib confirmed its extrapleural location. This lesion appeared to arise from the fourth rib at the costochondral junction. The preoperative diagnosis was a chondrosarcoma of the rib; this was confirmed at surgery. The tumor was completely removed en bloc, along with the third and fifth ribs. The surgical defect was closed with Teflon mesh, and the patient made an uneventful
Value of Exploratory "Scanning" in the Echocardiographic Diagnosis of Ruptured Chordae Tendineae
Authors: T. D. GILES, G. E. BURCH, E. C. MARTINEZ
Journal: Circulation (1974)

Echocardiographic diagnosis of rupture of the chordae tendineae to the anterior and posterior leaflets of the mitral valve may be difficult to make. Two patients, one with rupture of chordae tendineae to the posterior leaflet and the other with rupture of chordae tendineae to the anterior leaflet of the mitral valve, are reported to illustrate the use of an exploratory "continuous scanning" technique to facilitate and verify the echocardiographic diagnosis of these disorders. The elimination of confusing echocardiograms is emphasized.
RECENT EXPERIENCE OF SURGERY OF THE KIDNEY.
Authors: H. O. WALKER
Journal: JAMA (1896)

The paucity of literature upon renal surgery has prompted me to report three cases in which four operations were performed, representing nearly all the operative procedures that are now done upon the kidney. <h3>Case 1.</h3> Sacculated kidney with suppuration and nephrolithiasis, nephro-lithotomy and subsequent nephrectomy.—Aug. 4, 1896, J. R., age 29 years, was referred to me by Dr. E. M. Houghton for operation, with a history as follows: When 6 or 7 years of age he remembers having experienced severe pain in the region of the left kidney, which lasted for a day or two. These attacks occurred afterward at intervals of from one to three months; at one time he had none for nearly a year. He did not experience any disturbance of the bladder until he was about 12 or 14 years of age. This combination of pain in the region of the kidney and the bladder continued,
Personal paper: Risk of diabetic nephropathy in potential living related kidney donors
Authors: D Simmons, M Searle
Journal: BMJ (1998)

Diabetic nephropathy is the leading cause of end stage renal failure in New Zealand.1 Cadaveric organs are in short supply here, as elsewhere, and we need to consider living related donation. Kidneys from living related donors also provide a better graft and improved survival of transplant patients. However, donors from ethnic groups who have a high incidence of end stage renal failure because of diabetes and glomerulonephritis are also at increased risk of developing diabetes.2 This risk is compounded by environmental factors such as obesity. In New Zealand the ethics of living related donation within the diabetic family are being questioned.

Renal transplantation is preferred to dialysis in diabetic patients who are fit enough for surgery. It is associated with an improved quality of life, lower morbidity and mortality, reduced long term costs, and greater incremental benefit in diabetic patients compared with patients without diabetes.3 The main reason for not transplanting kidneys into suitable candidates is the low availability of compatible organs for transplantation. Some ethnic groups object to donating body parts after death for cultural and spiritual reasons. The resulting underrepresentation of these ethnic groups in the donor pool further reduces the likelihood that patients with end stage renal failure from these ethnic groups will receive an organ. Organ donation from living relatives is therefore particularly encouraged in these groups.

Diabetes and the development of nephropathy once diabetes has occurred are familial and cluster in families. 4 5 It is therefore important to be able to advise a potential donor of his or her personal risk of developing end stage renal failure.

Apart from …