THE CLINICAL SIGNIFICANCE OF THE LOW OR "FLAT" ORAL GLUCOSE TOLERANCE CURVE
Authors: Michael J. Lepore
Journal: Annals of Internal Medicine (1941)

Article1 May 1941THE CLINICAL SIGNIFICANCE OF THE LOW OR "FLAT" ORAL GLUCOSE TOLERANCE CURVEMICHAEL J. LEPOREMICHAEL J. LEPORESearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-14-11-2008 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptDuring the course of a study of sprue and allied deficiency states,1 low or "flat" oral glucose tolerance curves were observed very frequently in the affected individuals. This was not a novel observation, for other observers had had the same experience, and furthermore, had suggested that this finding serve as a diagnostic aid in the recognition of sprue.2, 3A review of the pertinent literature revealed considerable difference of opinion on the interpretation of the low oral glucose tolerance curve.2, 4, 5, 6It was felt that before relying too greatly upon the contour of the curve as a diagnostic...Bibliography1. LEPORE MJ: To be published. Google Scholar2. THAYSEN TE: Nontropical sprue, 1932, Oxford Univ. Press, London. Google Scholar3. HANESMCBRYDE FMA: Identity of sprue, nontropical sprue and celiac disease, Arch. Int. Med., 1936, lviii, 1-16. CrossrefGoogle Scholar4. MARTINSCICLOUNOFF EF: L'interet clinique des courbes basses d'hyperglycemie provoquee, Presse méd., 1939, xlvii, 503-506. Google Scholar5. VERZAR F: Absorption from the intestine, 1936, Longmans, Green and Co., London, New York. Google Scholar6. CRAWFORD T: Causation of low blood-sugar curve in coeliac disease, Quart. Jr. Med., 1939, viii, 251-260. Google Scholar7. FOLINWU OH: System of blood analysis; simplified and improved method for determination of sugar, Jr. Biol. Chem., 1920, xli, 367-374. CrossrefGoogle Scholar8. WERNER S: To be published. Google Scholar9. SWEENEY JS: Dietary factors that influence the dextrose tolerance test; preliminary study, Arch. Int. Med., 1927, xl, 818-830. CrossrefGoogle Scholar10. HIMSWORTH HP: Dietetic factor determining glucose tolerance and sensitivity to insulin of healthy men, Clin. Sci., 1935, ii, 67-94. Google Scholar11. SOSKINLEVINEHELLER SRRE: Carbohydrate utilization in hypophysectomized dog, Proc. Soc. Exper. Biol. and Med., 1938, xxxviii, 6-8. CrossrefGoogle Scholar12. ALTHAUSENSTOCKHOLM TLM: Influence of thyroid gland on absorption in digestive tract, Am. Jr. Physiol., 1938, cxxiii, 577-588. CrossrefGoogle Scholar13. DORST SE: Chronic hypoglycemia; problem in carbohydrate metabolism, Am. Jr. Med. Sci., 1938, cxcvi, 688-698. CrossrefGoogle Scholar14. GROEN J: Absorption of glucose from small intestine in deficiency disease, New England Jr. Med., 1938, ccxviii, 247-253. CrossrefGoogle Scholar15. LONGCOPE WT: Hypoglycemia in scleroderma; metabolism in eight cases with reference to function of glands of internal secretion, Jr. Am. Med. Assoc., 1928, xc, 1-7. Google Scholar16. ROSENOWJAGUTTIS G: Blood sugar in Addison's disease, Klin. Wchnschr., 1922, i, 358-360. CrossrefGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: New York, N. Y.*Received for publication February 24, 1940.From the Department of Medicine, College of Physicians and Surgeons, Columbia University and the Presbyterian Hospital, New York.With the technical assistance of Rhoda H. Bower. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byFlat Oral Glucose Tolerance Test During Pregnancy: Maternal Characteristics and Risk for Adverse OutcomesSignificance of the Flat Oral Glucose Tolerance TestOutbreaks of sprue during the Burma CampaignSprue 1 May 1941Volume 14, Issue 11Page: 2008-2013KeywordsHospital medicineOral glucose tolerance testSurgeons ePublished: 1 December 2008 Issue Published: 1 May 1941 PDF downloadLoading ...