FURTHER OBSERVATIONS ON RAPID HYPOSENSITIZATION
Authors: G. L. Waldbott, M. S. Ascher
Journal: Annals of Internal Medicine (1937)

Article1 April 1937FURTHER OBSERVATIONS ON RAPID HYPOSENSITIZATIONG. L. WALDBOTT, M.D., F.A.C.P., M. S. ASCHER, M.D.G. L. WALDBOTT, M.D., F.A.C.P.Search for more papers by this author, M. S. ASCHER, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-10-10-1556 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptRecent textbooks on allergy make only little mention of rapid hyposensitization † treatment and only a few clinicians have given this method serious consideration. The method of administering small increasing doses of antigen at short intervals was first introduced by Besredka1 for the avoidance of serum reactions after he had observed that in animals the re-injection of a sublethal dose of antigen resulted in a temporary state of anti-anaphylaxis and that during this state larger doses of antigen could be more readily tolerated.In 1930 Freeman2adopted this method of treatment for the relief of patients with hay-fever and asthma....Bibliography1. BESREDKA A: De la vaccination anti-anaphylactique, Compt. rend. Soc. de biol., 1908, lxv, 479. Google Scholar2. FREEMAN J: "Rush" inoculation, Lancet, 1930, i, 744. CrossrefGoogle Scholar3. TUFT L: Fatalities following the reinjection of foreign serum, Am. Jr. Med. Sci., 1928, clxxv, 325. BLANKENHORN, M. A.: Anaphylactic shock and failure of desensitization, Jr. Am. Med. Assoc., 1925, lxxxv, 325. CrossrefGoogle Scholar4. WALDBOTTASCHER GLMS: Rapid hyposensitization, Jr. Allergy, 1934, vi, 93. CrossrefGoogle Scholar5. VAUGHAN WT: An improved co-seasonal treatment, Jr. Allergy, 1932, iii, 542. PHILLIPS, E. W.: Intradermal pollen therapy during the attack, Jr. Allergy, 1933, v, 29. CrossrefGoogle Scholar6. WALDBOTTASCHER GLMS: The rôle of accidental puncture of veins in the production of allergic shock, ANN. INT. MED., 1936, ix, 1232-1239. Google Scholar7. RACKEMANNWAGNER FMHC: Specific desensitization of skin sites in actively sensitive persons, Jr. Allergy, 1936, vii, 542-551. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Detroit, Michigan*Received for publication January 25, 1937.†The term "hyposensitization" is used by some in order to indicate that "complete" desensitization, as in an anaphylactic animal, is impossible in man. We do not believe that such a distinction is possible since in man no one has ever given, for the purpose of desensitization, doses corresponding even approximately to those given to an anaphylactic animal per kilogram of body weight. However, we shall adhere to the common nomenclature to avoid confusion. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited bySPECIFIC HYPOSENSITIZATION OF PATIENTS WITH PENICILLIN ALLERGYRecent developments in asthma and hay feverThe optimal doses in pollen therapy 1 April 1937Volume 10, Issue 10Page: 1556-1564KeywordsAllergy and immunologyAntigensAsthmaBody weight ePublished: 1 December 2008 Issue Published: 1 April 1937 PDF downloadLoading ...