TREATMENT OF DIABETES MELLITUS WITH PROTAMINE INSULIN: IS A PERSISTENT GLYCOSURIA HARMFUL? A METABOLIC STUDY OF A SEVERE CASE
Authors: Edward Tolstoi, Thomas P. Almy, Vincent Toscani
Journal: Annals of Internal Medicine (1942)

Article1 May 1942TREATMENT OF DIABETES MELLITUS WITH PROTAMINE INSULIN: IS A PERSISTENT GLYCOSURIA HARMFUL? A METABOLIC STUDY OF A SEVERE CASEEDWARD TOLSTOI, M.D., THOMAS P. ALMY, M.D., VINCENT TOSCANI, B.S.EDWARD TOLSTOI, M.D.Search for more papers by this author, THOMAS P. ALMY, M.D.Search for more papers by this author, VINCENT TOSCANI, B.S.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-16-5-893 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTwo years ago, we presented our criteria for the satisfactory treatment of diabetes mellitus with protamine insulin. Briefly, we preferred (a) one injection a day, and (b) we were guided by the patient's weight, (c) his freedom from symptoms, (d) his freedom from ketonuria, and (e) the absence of insulin reactions. The experimental and clinical evidence upon which this treatment was based has been published in detail elsewhere.1 It was our experience that the most reliable protection the patient had from the hypoglycemic syndrome was a glycosuria. We, therefore, included among our criteria the desirability of a glycosuria.Our attitude...Bibliography1. TOLSTOIWEBER EFC: Protamine zinc insulin: a metabolic study, Arch. Int. Med., 1939, lxiv, 91. TOLSTOI, E., and WEBER, F. C., JR.: Protamine zinc insulin: a clinical study, Arch. Int. Med., 1940, lxvi, 670. CrossrefGoogle Scholar2. Correspondence, Jr. Am. Med. Assoc., 1940, cxv, 1038. CrossrefGoogle Scholar3. Editorial: Protamine insulin and diet in diabetes mellitus, ANN. INT. MED., 1938, xi, 2048. Google Scholar4. JOSLIN EP: Diabetes and protamine insulin, Mil. Surg., 1938, lxxxii, 1. WHITE, P.: Protamine insulin in the treatment of juvenile diabetes, South. Med. Jr., 1938, xxxi, 15. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: New York, N. Y.*Received for publication April 25, 1941.From the Department of Medicine, Cornell University Medical College, and the Russell Sage Institute of Pathology in affiliation with the New York Hospital, New York. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byCarbohydrate restriction for diabetes: rediscovering centuries-old wisdomTREATMENT OF DIABETES WITH “FREE DIET” DURING THE PAST TEN YEARSHigh carbohydrate diet in the treatment of diabetes mellitusCarbohydrate consumption and diabetesDiabetesDiabetes Mellitus in Early Infancy, Treated without Dietary RestrictionsA liberal regimen of treatment of diabetesNewer concepts in the treatment of diabetes mellitus with protamine insulinTreatment of diabetes mellitus without regard to hyperglycemia and glycosuria 1 May 1942Volume 16, Issue 5Page: 893-903KeywordsDiabetes mellitusHospital medicineHypoglycemicsInsulinProtamines ePublished: 1 December 2008 Issue Published: 1 May 1942 PDF downloadLoading ...