PSEUDOMEMBRANOUS ENTEROCOLITIS AND ANTIBIOTICS
Authors: C R NEWMAN
Journal: Annals of Internal Medicine (1956)

Article1 September 1956PSEUDOMEMBRANOUS ENTEROCOLITIS AND ANTIBIOTICSC. R. NEWMAN, M.D., F.A.C.P.C. R. NEWMAN, M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-45-3-409 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptINTRODUCTIONPseudomembranous inflammation of the intestine has been recognized for over a century. During the last several years there has been an apparent increase in its incidence. Disagreement has existed regarding the role of antibiotics in the etiology of this condition. Some authors claim relatively no increase as the result of widespread use of antibiotics, whereas others take the opposite view. Recent experiences, however, which indicate the etiologic importance of antibiotic-resistant staphylococci have produced a greater alertness and suspicion by physicians generally, and more antemortem diagnoses are being made. The precise role of the antibiotics has not been definitely established,...Bibliography1. Coates J: A manual of pathology, 1883, Henry C. Lea's Son and Co., Philadelphia, Pa. Google Scholar2. Lazarus-Barlow WS: A manual of general pathology, 1898, P. Blakiston's Son and Co., Philadelphia, Pa. Google Scholar3. Kaufman E: Pathology for students and practitioners, Vol. I, 1929, P. Blakiston's Son and Co., Philadelphia, Pa. Google Scholar4. McCallum WG: A textbook of pathology, 6th Ed., 1938, W. B. Saunders Co., Philadelphia, Pa. Google Scholar5. McCutcheon M: Pathology, edited by Anderson, W. A. D., 1948, The C. V. Mosby Co., St. Louis, Mo. Google Scholar6. Cappell DF: Muir's Textbook of pathology, 6th Ed., 1951, The Williams and Wilkins Co., Baltimore, Md. Google Scholar7. PennerBernheim AAI: Acute postoperative enterocolitis, Arch. Path. 27: 966, 1931. Google Scholar8. PennerDruckerman ALJ: Enterocolitis as a postoperative complication and its significance, Gastroenterology 11: 478, 1948. MedlineGoogle Scholar9. ProhaskaGovostisTaubenhaus JVMCM: Postoperative pseudomembranous enterocolitis, successful treatment with corticotropin (ACTH), J. A. M. A. 154: 320, 1954. CrossrefMedlineGoogle Scholar10. KlecknerBargenBaggenstoss MSJAAH: Pseudomembranous enterocolitis: clinicopathological study of fourteen cases in which the disease was not preceded by an operation, Gastroenterology 21: 212, 1952. CrossrefMedlineGoogle Scholar11. PettetBaggenstossDearingJudd JDAHWHES: Postoperative pseudomembranous enterocolitis, Surg., Gynec. and Obst. 98: 546, 1954. MedlineGoogle Scholar12. PettetBaggenstossJuddDearing JDAHESWH: Generalized postoperative pseudomembranous enterocolitis, Proc. Staff Meet., Mayo Clin. 29: 342, 1954. MedlineGoogle Scholar13. ReinerSchlesingerMiller LMJGM: Pseudomembranous enterocolitis following Aureomycin and chloramphenicol, Arch. Path. 54: 39, 1952. MedlineGoogle Scholar14. WeinsteinGoldfieldChang LMT: Infections occurring during chemotherapy; a study of their frequency, type, and predisposing factors, New England J. Med. 251: 247, 1954. CrossrefMedlineGoogle Scholar15. Garrod LP: The reactions of bacteria to chemotherapeutic drugs, Brit. M. J. 1: 205, 1951. CrossrefMedlineGoogle Scholar16. FinlandWeinstein ML: Complications induced by antimicrobial agents, New England J. Med. 248: 220, 1953. CrossrefMedlineGoogle Scholar17. Kligman AM: Are fungus infections increasing as a result of antibiotic therapy? J. A. M. A. 149: 979, 1952. CrossrefMedlineGoogle Scholar18. Harris HJ: Aureomycin and chloramphenicol in brucellosis with special reference to side effects, J. A. M. A. 142: 161, 1950. CrossrefMedlineGoogle Scholar19. MerlissHoffman RRA: Steatorrhea following the use of antibiotics, New England J. Med. 245: 328, 1951. CrossrefMedlineGoogle Scholar20. LohBaker WPEE: Alteration in the fecal flora of man following oral Aureomycin or Terramycin, Boston M. Quart. 4: 87, 1953. Google Scholar21. Rantz LA: Consequences of the widespread use of antibiotics, California Med. 81: 1, 1954. MedlineGoogle Scholar22. Thomson E: The dangers of antibiotics, M. J. Australia 1: 870, 1952. CrossrefMedlineGoogle Scholar23. Smith DT: The disturbance of the normal bacterial ecology by the administration of antibiotics with development of new clinical syndromes, Ann. Int. Med. 37: 1135, 1952. LinkGoogle Scholar24. TerrellMaynard RAd: Anorectal side effects of antibiotic therapy, J. A. M. A. 156: 217, 1954. CrossrefMedlineGoogle Scholar25. Manheim SD: Anorectal complications of Aureomycin, Terramycin, and Chloromycetin therapy, New York State J. Med. 51: 2759, 1951. MedlineGoogle Scholar26. Herrell WE: A consideration of the newer antibiotics, Am. J. Surg. 82: 638, 1951. CrossrefMedlineGoogle Scholar27. JacksonHaightKassWomackGockeFinland GGTHEHCRTMM: Terramycin therapy of pneumonia: clinical and bacteriological studies in 91 cases, Ann. Int. Med. 35: 1175, 1951. LinkGoogle Scholar28. AhernKirby JJWM: Lack of interference of Aureomycin with penicillin in treatment of pneumococcic pneumonia, Arch. Int. Med. 91: 197, 1953. CrossrefGoogle Scholar29. Newhauser I: Successful treatment of intestinal moniliasis with fatty-acid resin complex, Arch. Int. Med. 93: 53, 1954. CrossrefGoogle Scholar30. Di CaprioRantz JMLA: Effects of Terramycin on bacterial flora of the bowel in man, Arch. Int. Med. 86: 649, 1950. CrossrefGoogle Scholar31. DearingHeilman WHFR: Micrococcic (staphylococcic) enteritis as a complication of antibiotic therapy; its response to erythromycin, Proc. Staff Meet., Mayo Clin. 28: 121, 1953. MedlineGoogle Scholar32. Prissick FH: Antibiotic resistant staphylococci and related infections, Am. J. M. Sc. 225: 299, 1953. MedlineGoogle Scholar33. Welch H: Antibiotic resistant staphylococci, Antibiotics and Chemotherapy 3: 561, 1953. Google Scholar34. FairlieKendall CWRE: Fatal staphylococcus enteritis following penicillin and streptomycin therapy, J. A. M. A. 155: 90, 1953. CrossrefGoogle Scholar35. Kramer IR: Fatal staphylococcal enteritis developing during streptomycin therapy by mouth, Lancet 2: 646, 1948. CrossrefMedlineGoogle Scholar36. FinlandHaight MTH: Antibiotic resistance of pathogenic staphylococci, Arch. Int. Med. 91: 143, 1953. CrossrefGoogle Scholar37. Spink WW: Staphylococcic infections and the problem of antibiotic resistant staphylococci, Arch. Int. Med. 94: 167, 1954. CrossrefGoogle Scholar38. FinlandGrigsbyHaight MMETH: Efficacy and toxicity of oxytetracycline (Terramycin) and chlortetracycline (Aureomycin): with special reference to use of doses of 250 mgs. every four to six hours and to occurrence of staphylococcic diarrhea, Arch Int. Med. 93: 23, 1954. CrossrefGoogle Scholar39. Editorial: Antibiotics, staphylococcal enteritis, and pseudomembranous colitis, New England J. Med. 249: 37, 1953. CrossrefMedlineGoogle Scholar40. Yow EM: Development of proteus and pseudomonas infections during antibiotic therapy, J. A. M. A. 149: 1184, 1952. CrossrefMedlineGoogle Scholar41. TerplanPaineShefferEganLansky KJRJRH: Fulminating gastroenterocolitis caused by staphylococci; its apparent connection with antibiotic medication, Gastroenterology 24: 476, 1953. CrossrefMedlineGoogle Scholar42. BrownWinstonSommers WJRSC: Membranous staphylococcal enteritis after antibiotic therapy; report of two cases, Am. J. Digest. Dis. 20: 73, 1953. CrossrefMedlineGoogle Scholar43. HilsabeckDixon JRCF: The treatment of acute postoperative pseudomembranous colitis, Am. J. Surg. 84: 114, 1952. CrossrefMedlineGoogle Scholar44. ChristiansonDacquistoDobbs CSMPWH: Micrococcic (staphylococcic) enteritis: recovery following shock, Gastroenterology 26: 645, 1954. CrossrefMedlineGoogle Scholar45. NyhusBurke REEC: Pseudomembranous enterocolitis; medical treatment with recovery, Proc. Staff Meet., Mayo Clin. 29: 513, 1954. MedlineGoogle Scholar46. MartinNicholsWellmanGeraci WJDRWEJE: Changes in sensitivity of Micrococcus pyogenes to erythromycin over a period of two years, Proc. Staff Meet., Mayo Clin. 29: 379, 1954. MedlineGoogle Scholar47. HerrellNicholsMartin WEDRWJ: Erythromycin for infections due to Micrococcus pyogenes , J. A. M. A. 152: 1601, 1953. CrossrefMedlineGoogle Scholar48. Schneierson SS: Changes in bacterial sensitivity to Aureomycin and chloramphenicol in the course of the past three years, J. Lab. and Clin. Med. 40: 48, 1952. MedlineGoogle Scholar49. HaightFinland THM: Laboratory and clinical studies with erythromycin, New England J. Med. 247: 227, 1952. CrossrefMedlineGoogle Scholar50. Finney JM: Gastroenterostomy for cicatrizing ulcer of the pylorus, Bull. Johns Hopkins Hosp. 4: 53, 1893. Google Scholar51. Finland M: Antibiotics and staphylococci (Editorial), Antibiotic Med. 1: 3, 1955. Google Scholar52. Color atlas of pathology, U. S. Naval Medical School, Vol. I, 1950, Lippincott Co., Philadelphia. Google Scholar53. Cole LR: Recovery of Aureomycin from the gastrointestinal tract following intravenous administration, J. Lab. and Clin. Med. 41: 670, 1953. MedlineGoogle Scholar54. Wood GB: A treatise on the practice of medicine, Vol. I, 1849, Gregg, Elliott and Co., Philadelphia, Pa. Google Scholar55. Watson T: Lectures on the principles and practice of physic, 1858, Blanchard and Lea, Philadelphia, Pa. Google Scholar56. Aitken W: The science and practice of medicine, Vols. I and II, 1868, Lindsay and Blakiston, Philadelphia, Pa. Google Scholar57. Hartshorne H: A system of medicine, edited by Reynolds, J. R., Vol. III, 1880, Henry C. Lea's Son and Co., Philadelphia, Pa. Google Scholar58. DearingNeedham WHGM: The effect of oral administration of neomycin and oxytetracycline (Terramycin) on the intestinal bacterial flora in man, Proc. Staff Meet., Mayo Clin. 28: 507, 1953. MedlineGoogle Scholar59. DearingNeedham WHGM: The effect of oral administration of neomycin on the intestinal bacterial flora in man, Proc. Staff Meet., Mayo Clin. 28: 512, 1953. Google Scholar60. Beckman H: Comments on treatment, Wisconsin M. J. 53: 219, 1954. Google Scholar61. MartinNicholsGeraci WJDRJE: The present status of erythromycin, Proc. Staff Meet., Mayo Clin. 28: 609, 1953. MedlineGoogle Scholar62. Finland M: Antibiotic resistant micrococcic infections, J. A. M. A. 158: 188, 1955. CrossrefMedlineGoogle Scholar63. SurgallaDack MJGM: Enterotoxin produced from cases of enteritis after antibiotic therapy, J. A. M. A. 158: 649, 1955. CrossrefMedlineGoogle Scholar64. JonassenFierstCincotti OTSMJJ: Management of postoperative pseudomembranous enterocolitis with shock, New England J. Med. 252: 792, 1955. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Racine, Wisconsin*Received for publication October 7, 1955.Requests for reprints should be addressed to C. R. Newman, M.D., 810 Main Street, Racine, Wisconsin. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byColitis and diarrhoea: A problem with antibiotic therapyClindamycin in the treatment of soft tissue infections: A review of 15 019 patientsAcute necrotizing (pseudomembranous) enterocolitisSurgical Aspects of TherapyPseudomembranous enterocolitisClindamycin Associated DiarrheaDiarrhoea and Colitis Associated with Antibiotic Treatment: A Report of 16 casesSpectrum of Acute Diarrhea in a General HospitalSome histological aspects of behavior of epidermoid carcinoma in situ and related lesions of the uterine cervix.A long-term prospective studyTHE BOWEL IN SHOCK THE ROLE OF MESENTERIC ARTERIAL DISEASE AS A CAUSE OF DEATH IN THE ELDERLYDie Enterocolitis acuta als postoperative KomplikationErythromycinShock in infectious diseasesPseudomembranous EnterocolitisAcute Staphylococcal Enterocolitis Complicating Oral Neomycin Therapy in CirrhosisDangers of intestinal antisepsisIatrogenic Diseases of the Gastrointestinal TractEnterocolitis acuta pseudomembranacea, eine postoperative ZweiterkrankungThe Microbiology of the Oral CavityFortschritte und Probleme in der Dünndarmpathologie 1 September 1956Volume 45, Issue 3Page: 409-444KeywordsAntibioticsEnterocolitisEtiologyInflammationPathologistsSuperinfections ePublished: 1 December 2008 Issue Published: 1 September 1956 PDF downloadLoading ...