DIRECT MEASUREMENTS OF THE EFFECTS OF BROMIDES, SODIUM AMYTAL AND OF CAFFEINE IN MAN
Authors: Edmund Jacobson
Journal: Annals of Internal Medicine (1944)

Article1 September 1944DIRECT MEASUREMENTS OF THE EFFECTS OF BROMIDES, SODIUM AMYTAL AND OF CAFFEINE IN MANEDMUND JACOBSON, PH.D., M.D., F.A.C.P.EDMUND JACOBSON, PH.D., M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-21-3-455 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptMany publications appear each year concerning the influence of stimulants and sedatives in animals and in man. Investigations have afforded much indirect evidence of the action of such agents on the nervous and muscular systems. However, direct quantitative measurements of functional states in the intact organism following the administration of pharmacological substances have never been attempted, doubtless because of lack of suitable instruments. The possibility of such investigation has finally been opened by advances in electrophysiology in the last decade. Most convenient for the present investigation, which I believe marks a first step in this special field, is apparatus capable...Bibliography1. JACOBSON E: (a) The direct measurement of nervous and muscular states with the integrating neurovoltmeter (action-potential integrator), Am. Jr. Psychiat., 1940, xcvii, 513; (b) An integrating voltmeter for the study of nerve and muscle potentials, Rev. Sci. Instr., 1940, xi, 415; (c) Recording action-potentials without photography, Am. Jr. Psychol., 1941, liv, 266. CrossrefGoogle Scholar2. WESTPHAL C: Ueber einige Bewegungs-Erscheinungen an gelähmten Gliedern, Arch. f. Psychiat., 1875, v, 803; ERB, W.: Ueber Sehnenreflexe bei Gesunden und bei Rückenmarkskranken, Arch. f. Psychiat., 1875, v, 792; MITCHELL S. W. LEWIS M. J.: The tendon-jerk and muscle-jerk in disease and especially in posterior sclerosis, Trans. Assoc. Am. 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CrossrefGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Chicago, Illinois*Received for publication October 13, 1943.From the Laboratory for Clinical Physiology, Chicago.Read in abstract before the Section of Pharmacology at the Boston Meeting of The Federation of American Societies for Experimental Biology, April 4, 1942. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byElectrophysiology of Mental Activities and Introduction to The Psychological Process of ThinkingCEREBELLAR SYNDROME FOLLOWING SODIUM AMYTAL 1 September 1944Volume 21, Issue 3Page: 455-468KeywordsCaffeineClinical laboratoriesElectrophysiological techniquesNervous systemPharmacologyResearch laboratoriesSedativesSodium ePublished: 1 December 2008 Issue Published: 1 September 1944 PDF downloadLoading ...