tbuckley/cabot-search huggingface dataset:
The relationship between anthropometric and physiological variables elite distance and middle distance runners of Iranian national team
Authors: Matinhomaee Hassan
Journal: British Journal of Sports Medicine (2010)

The purpose of this research is to define the relationship between anthropometric and physiological variables in elite distance and middle distance runners of Iranian national athletics team for the 3000 m performance. To do this, a sample of 30 elite runners with the mean age of 21.10±0.63 and mean height of 177.8±5.82 and mean weight of 64.26±7.07 were used. Characteristics of anthropometric and physiological and their relationship for the athletes were measured. The Pearson regression with (p≤0.05) was used for this analysis. From 41 variables 8 of them had a meaningful relationship with the performance of athletes which from these body fat mass (kg) and percentage of fat (%) had a positive and meaningful relationship with the performance and a negative and meaningful relationship between distribution of fat and performance. Between VO 2 max (ml/min/kg), anaerobic power, VO 2 max LT (ml/min) and the performance there was a negative and meaningful relationship. Between rest heart rate, breath rate and the performance there was a positive and meaningful relationship.
Bioethics, Public Moral Argument, and Social Responsibility
Authors: Marcel Levi
Journal: JAMA (2012)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Plastic Surgery: A Concise Guide to Clinical Practice
Authors: David W. Furnas
Journal: JAMA (1968)

Two leading plastic surgeons, William C. Grabb of the University of Michigan, and James W. Smith of New York Hospital-Cornell Medical Center, have edited plastic surgery's best bargain of the year. The 43 authors are mostly drawn from the Young Turks of plastic surgery (plus a few barely middle-aged Turks), internationally known for the topics they present. Every medical student and surgical resident should read part 1, the first tenth of the book, which is a lucidly illustrated, clearly worded guide to the art of cutting, stitching, and grafting skin. Homely lessons which surgeons usually learn from experience have been put into print: catgut sutures in the oral mucosa are notorious for coming untitled—use silk; when long wounds are closed by subcuticular monofilament sutures, pass the suture through the skin every 2 or 3 inches—or suture removal will be a tussle. Recently applied tools, such as wound adhesives and microporous
Inhibition of Syk with fostamatinib disodium has significant clinical activity in non-Hodgkin lymphoma and chronic lymphocytic leukemia
Authors: Jonathan W. Friedberg, Jeff Sharman, John Sweetenham, Patrick B. Johnston, Julie M. Vose, Ann LaCasce, Julia Schaefer-Cutillo, Sven De Vos, Rajni Sinha, John P. Leonard, Larry D. Cripe, Stephanie A. Gregory, Michael P. Sterba, Ann M. Lowe, Ronald Levy, Margaret A. Shipp
Journal: Blood (2009)
Found in the Street
Authors: Richard Bronson
Journal: JAMA (2014)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Acute circulatory support.
Authors: M J Barnard, S P Linter
Journal: BMJ (1993)

Numerous drugs can increase cardiac output, thereby improving tissue oxygen delivery, but often they do this at the expense of increasing myocardial oxygen demand. This may be critical when cardiac function is substantially impaired or ischaemia is the precipitating cause. Using polypharmacy to substantially improve cardiovascular status requires detailed knowledge of the pharmacodynamics and interactions of the available agents so that they may be tailored to the individual patient. In some settings combinations of inotropes and vasodilators may be desirable to minimise cardiac workload. In other instances vasopressors may be necessary to urgently restore a minimum perfusion pressure. This paper reviews the use of this group of drugs as well as the mechanical assist devices that may be used when drugs fail.
Dissecting Aneurysm in Pregnancy Associated with Aortic Insufficiency
Authors: Michael Hume, Gerald Krosnick
Journal: New England Journal of Medicine (1963)

THE various surgical technics now available for the management of dissecting aneurysm of the aorta have recently been summarized.1 Alertness and an aggressive approach in diagnosis and treatment will be rewarded with an increasingly favorable prognosis in the patients who do not succumb abruptly in the initial phase of the disease. Pregnancy is one of the conditions with which aortic medial necrosis and dissecting aneurysm are associated. Acute aortic insufficiency as a further complication of dissecting aneurysm in pregnancy is relatively uncommon, and the management of such a case, reported below, illustrates many of the technical difficulties that may be . . .
Effect of clomifene citrate plus metformin and clomifene citrate plus placebo on induction of ovulation in women with newly diagnosed polycystic ovary syndrome: randomised double blind clinical trial
Authors: Etelka Moll, Patrick M M Bossuyt, Johanna C Korevaar, Cornelis B Lambalk, Fulco van der Veen
Journal: BMJ (2006)

<h3>Abstract</h3> Development is largely driven by transitions between transcriptional programs. The initiation of transcription at appropriate sites in the genome is a key component of this and yet few rules governing selection are known. Here, we used cap analysis of gene expression (CAGE) to generate bp-resolution maps of transcription start sites (TSSs) across the genome of <i>Oikopleura dioica</i>, a member of the closest living relatives to vertebrates. Our TSS maps revealed promoter features in common with vertebrates, as well as striking differences, and uncovered key roles for core promoter elements in the regulation of development. During spermatogenesis there is a genome-wide shift in mode of transcription initiation characterized by a novel core promoter element. This element was associated with &gt; 70% of transcription in the testis, including the male-specific use of cryptic internal promoters within operons. In many cases this led to the exclusion of <i>trans</i>-splice sites, revealing a novel mechanism for regulating which mRNAs receive the spliced leader. During oogenesis the cell cycle regulator, E2F1, has been co-opted in regulating maternal transcription in endocycling nurse nuclei. In addition, maternal promoters lack the TATA-like element found in vertebrates and have broad, rather than sharp, architectures with ordered nucleosomes. Promoters of ribosomal protein genes lack the highly conserved TCT initiator. We also report an association between DNA methylation on transcribed gene bodies and the TATA-box, which indicates that this ancient promoter motif may play a role in selecting DNA for transcription-associated methylation in invertebrate genomes.
Enhancement of procainamide-induced rate-dependent conduction slowing by elevated myocardial extracellular potassium concentration in vivo.
Authors: W E Cascio, J R Foster, J W Buchanan, T A Johnson, L S Gettes
Journal: Circulation (1987)

Procainamide, a type 1A antiarrhythmic drug, blocks sodium channels and reduces the maximum rate of rise of the cardiac action potential (Vmax) in a rate-dependent fashion. In vitro, the magnitude of this rate-dependent reduction in Vmax is greater in tissue that is partially depolarized at rest than in tissue with a normal resting potential. Reductions in Vmax produced by drugs that block sodium channels are also directly related to the reductions in longitudinal conduction velocity of action potential propagation in papillary muscle preparations. We therefore sought to determine whether the rate-dependent conduction slowing induced by procainamide in the intact canine heart is enhanced in myocardial tissue abnormally depolarized by an elevated myocardial extracellular potassium concentration, [K+]o. QRS duration and epicardial activation times were measured as indexes of myocardial conduction. QRS duration and epicardial activation times were measured at control (4.0 mM) and at intermediate (6.5 mM) and high (9.2 mM) myocardial [K+]o in the presence or absence of a clinically relevant procainamide concentration (12.2 +/- 2.6 g/ml) at the longest obtainable interstimulus interval of 440 msec and at 330, 280, and 250 msec. Intermediate and high myocardial [K+]o alone induced rate-dependent conduction slowing as the frequency of stimulation increased (cycle length 440 msec to 330, 280, and 250 msec). In the presence of procainamide, rate-dependent conduction slowing was observed at all levels of myocardial [K+]o, and the amount of rate-dependent change in conduction time increased as the myocardial [K+]o was increased.(ABSTRACT TRUNCATED AT 250 WORDS)
Pneumoconiosis from Agricultural Dust Exposure among Young California Farmworkers
Authors: Marc B. Schenker, Kent E. Pinkerton, Diane Mitchell, Val Vallyathan, Brenda Elvine-Kreis, Francis H.Y. Green
Journal: Environmental Health Perspectives (2009)

BackgroundAgricultural workers are exposed to airborne pollutants, including organic and inorganic (mineral) dusts.ObjectivesLung autopsy specimens from consecutive coroner's cases of Hispanic males in Fresno County, California, (n = 112) were obtained to determine whether mineral dust exposure in agricultural work leads to pneumoconiosis.MethodsThe left lung was fixed by inflation. We evaluated airway and parenchymal pathology using standardized diagnostic criteria and semiquantitative grading schemata, including the grading of small airways for fibrosis and birefringent mineral dust particles. We analyzed lung dust burden on a subset of 37 lungs following bleach digestion, using scanning electron microscopy (SEM), X-ray spectrometry (XRS) and image analysis, and by X-ray diffraction for crystalline silica (CSi). Farmworkers comprised 51.5% and nonfarmworkers 48.5% of the samples.ResultsProximal airways demonstrated little mineral dust accumulation, but membranous and respiratory bronchioles had wall thickening, remodeling, and inflammation associated with carbonaceous and mineral dust deposition. These changes were independently associated with agricultural work, cigarette smoking, and increased age. Mineral dust small airways disease, pneumoconiosis (macules and nodules), and pathologic changes consistent with chronic bronchitis, emphysema, and interstitial fibrosis predominated in farmworkers compared with nonfarmworkers. CSi, determined gravimetrically, and aluminum silicate particles, determined by SEM/XRS, were increased in the lungs of farmworkers compared with nonfarmworkers and were significantly (p < 0.05) associated with small airway disease and pneumoconiosis.ConclusionMineral dust exposure is associated with increased small airway disease and pneumoconiosis among California farmworkers; however, the clinical significance and natural history of these changes remains to be determined.
Not Professor Forel's Assistant.
Authors: August Forel
Journal: JAMA (1904)

Chiguy, Switzerland, April 6, 1904. <h3>To the Editor:</h3> —From August, 1879, until March, 1898, I was the director of the Burghölzh Insane Asylum and professor of psychiatry at the University of Zurich, and I desire to make the following statement: Dr. Carl Bertuhringer, who designates himself a representative of the so-called Koenig Medicine Company of Chicago, and who incidentally represents himself as a former assistant to Professor Forel at the Burghölzh Asylum, was never my assistant and never an assistant at the Burghölzh Asylum. He did, indeed, study medicine in Zurich, and, like other students, studied psychiatry with me, and practiced in the clinic as a so-called<i>practikant</i>, as did other students. Under these circumstances I once permitted him to hypnotize one patient. But he was never either my asylum assistant or my private assistant, and hence has no right to publish himself as such. Another Dr. Bertuhringer (Dr. Hans
Passive smoking as a determinant of bronchial responsiveness in children.
Authors: F Forastiere, N Agabiti, G M Corbo, R Pistelli, V Dell'Orco, G Ciappi, C A Perucci
Journal: American Journal of Respiratory and Critical Care Medicine (1994)

The effect of passive smoking on the degree of nonspecific bronchial responsiveness (BR) in children was evaluated. In a cross-sectional survey of primary school children (7 to 11 yr) in Latium (Italy), a total of 1,215 methacholine challenge tests was performed. The children were divided into nonresponders (PC20 FEV1 > 64 mg/ml) and responders (PC20 FEV1 < or = 64 mg/ml), the latter including a subgroup of strong responders (PC20 FEV1 < or = 4.0 mg/ml). The role of passive smoking exposure was analyzed through logistic regression models. Higher odds ratios were found among girls (for strong responders: maternal smoking, OR 2.92; paternal smoking, OR 2.59); moreover, among girls there was a dose-response relationship with the number of cigarettes smoked by the mother. An effect modification was also detected for father's education and household crowding: maternal and paternal smoking were strong predictors of bronchial hyperresponsiveness in families in which the head was less educated and in overcrowded houses. The results were confirmed using a continuous index of BR (slope) and after adjustment for baseline airway caliber. We suggest that the effect of parental smoking on children's bronchial responsiveness is detectable when the conditions for a higher exposure level at home are met; females seem to be more susceptible.
Acute mesenteric ischaemia caused by Schistosoma mansoni infection.
Authors: S Anayi, N Al-Nasiri
Journal: BMJ (1987)

during an influenza epidemic.We have shown, however, that subunit vaccine is well tolerated by asthmatic patients and is immunogenic.We thank Miss Dee Smith and Mr A Freke for valuable laboratory help and Mrs Peters, Mrs Williams, and Mrs Cook for typing the manuscript.We are grateful to Duphar Laboratories Ltd for their help
CANDESARTAN ATTENUATES AGING-RELATED INCREASE IN VENTRICULAR, ATRIAL AND RENAL FIBROSIS AND REMODELING AFTER REPERFUSED MYOCARDIAL INFARCTION IN RATS
Authors: Bodh I. Jugdutt, Arivazhagan Palaniyappan, Halliday Idikio
Journal: Journal of the American College of Cardiology (2012)
WHAT CREDIT, IF ANY, SHALL BE GIVEN THE HOLDERS OF BACCALAUREATE DEGREES FOR ADMISSION TO ADVANCED STANDING IN MEDICAL SCHOOLS?
Authors: HENRY L. TAYLOR
Journal: JAMA (1904)

<h3>PRINCIPAL CAUSES FOR THE DISCUSSION.</h3> When beginning preparation on this paper I was surprised to find how closely the closing paragraph of my remarks before this Association last year applied to the theme of this year's discussion. The substance of this paragraph may properly begin the discussion of my topic: The allowance to be made graduates of colleges of liberal arts and science must receive careful attention. The independent colleges and medical schools suffer by the drifting of their students to the universities that can afford both lines of work and a combined course, saving one or two years of time. The presidents of independent colleges plead for subjects that they regard as essential to liberal culture—for example, psychology—while the deans of the independent medical schools plead for their share of the stronger students with the college training. All seem agreed, however, that the matriculate possessing the baccalaureate
Taxane-Based Chemotherapy for Node-Positive Breast Cancer — Take-Home Lessons
Authors: Matthew Ellis
Journal: New England Journal of Medicine (2010)

Over the past several decades, taxane-based chemotherapy regimens for breast cancer have evolved through a large number of randomized studies designed to detect modest improvements in patient outcome with changes in the dose, schedule, and agent or agents. Consequently, the choice of regimen remains confusing, even for the seasoned practitioner, let alone for a patient trying to make an informed decision. The National Surgical Adjuvant Breast and Bowel Project B-30 trial, reported on by Swain et al.1 in this issue of the Journal, is a good example of how clinical trials of chemotherapy in breast cancer are designed and performed. . . .
Abstract 4779: Circulating and tumor-infiltrating CD4+IL-17+ T-cells in mice bearing orthotopic and heterotopic prostate tumors
Authors: Tzong-Tyng Hung, Pamela J. Russell, Carl A. Power
Journal: Cancer Research (2010)

Abstract Helper T-cells expressing interleukin-17 are classified as TH17 cells, which are important in autoimmune disease and inflammatory responses. However, there are limited studies on their role and effects on cancer development and progression. Here we used a syngeneic murine model for prostate cancer, RM1(BM)-B4H7-Luc, to evaluate the proportion of TH17 cells in various organs (spleen, lymph nodes, prostate) and peripheral blood of tumour-bearing mice compared to normal mice. The number of tumour-infiltrating TH17 cells in tumours located at different sites (subcutaneous and prostate) were also compared. The proportion of TH17 cells in the peripheral blood of prostate tumour-bearing mice was significantly higher than in age-matched control mice (p&amp;lt;0.05) or mice bearing subcutaneous tumours (p&amp;lt;0.05). Additionally, an increase in the proportion of tumour-infiltrating CD4+ T cells expressing IL-17 was observed in both subcutaneous (9.28%) and prostate tumours (10.2%) compared to lymphoid organs (spleen and lymph node, &amp;lt;1%) from these mice, suggesting sequestration of these cells within the tumour. In addition, significantly higher numbers of TH17 cells were detected in prostate tumours compared to normal prostates (p=0.0357). Finally, the percentage TH17 in the peripheral blood of mice with prostate tumours correlated with the size of the tumour ((R2=0.84, p=0.0014). In conclusion, in our model, we show that TH17 cells are a significant proportion of tumour infiltrating T-cells and, as proposed in recent studies, they are likely to be involved in the anti-tumour immunity/tumour rejection. Importantly, the number of circulating TH17 cells correlates with tumour size for prostatic tumours, but not subcutaneous tumours. Thus, assessment of peripheral blood TH17 cells may be an effective tool for diagnosis/prognosis of prostate cancer. This relationship does not hold if subcutaneous models are used for preclinical studies. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 101st Annual Meeting of the American Association for Cancer Research; 2010 Apr 17-21; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2010;70(8 Suppl):Abstract nr 4779.
Reviews and Notes: Ethics: Ethics in Emergency Medicine
Authors: David L. Jackson
Journal: Annals of Internal Medicine (1996)

Literature of Medicine1 March 1996Reviews and Notes: Ethics: Ethics in Emergency MedicineDavid L. Jackson, MD, PhDDavid L. Jackson, MD, PhDAssurQual, Inc., Baltimore, MD 21230Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-124-5-199603010-00027 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail 2nd edition. KV Iverson, AB Sanders, and D Mathieu; eds. 519 pages. Tucson, AZ: Galen Pr; 1995. $39.95. ISBN 1-883620-14-7. Order phone 520-577-8363.Developing the knowledge and the abilities needed to apply ethical principles effectively in clinical decision making is a challenge that is underemphasized, both in medical education and in the hectic pace of clinical practice. These issues are even more difficult to address in settings in which the severity of illness increases the need for rapid decision making.The emergency department is a place where special problems in practical medical ethics are confronted daily. The second edition of ... Author, Article, and Disclosure InformationAffiliations: AssurQual, Inc., Baltimore, MD 21230 Previousarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 March 1996Volume 124, Issue 5Page: 538KeywordsBioethicsDecision makingEmergency departmentEmergency medicineForecastingHealth careLibrariesMedical educationMedical ethicsWilderness ePublished: 15 August 2000 Issue Published: 1 March 1996 Copyright & PermissionsCopyright © 1996 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
PLASMA LIPOPROTEIN METABOLISM IN PERFUSED RAT LIVERS. I. PROTEIN SYNTHESIS AND ENTRY INTO THE PLASMA*
Authors: David E. Haft, Paul S. Roheim, Abraham White, Howard A. Eder
Journal: Journal of Clinical Investigation (1962)

The rates of synthesis of high density (D 1.063 to 1.21) and low density (D < 1.063) lipoproteins by the isolated perfused rat liver were compared in experiments in which uniformly labeled L-lysine-C/sup 14/ was added (by continuous injection) to the perfusing blood, When livers of rats fed a stock diet were perfused with blood from fasted rats, the specific activity of the protein of the D < 1.063 fraction was about four times that of the D 1.063 to 1.21 fraction, although the former contained somewhat less than half of the total radioactivity incorporated into lipoprotein protein because of its low concentration in rat plasma. The specific activity of albumin separated by starch block electrophoresis was less than that of either lipoprotein fraction. Neither previous whole-body irradiation nor Prefeeding the liver donor with a cholesterol-olive oil regimen caused any significant change in the rates of incorporation of lysine into the major lipoprotein classes, although these treatments markedly influenced cholesterologenesis. When normal livers were perfused with blood from cholesterol-fed rats, there was a twofold increase in the amount of D < 1.063 lipoprotein recovered and a corresponding increase in the incorporation of labeled amino acid into this material. When amore » D < 1.019 fraction was separated, it was found that this fraction had a specific activity greatly exceeding that of both the D 1.019 to 1.063 and D 1.063 to 1.21 lipoproteins. (auth)« less