tbuckley/cabot-search huggingface dataset:
The influence of cultural and educational factors on the validity of symptom and diagnosis questions for atopic eczema
Authors: None KRÄmer, None SchÄfer, None Behrendt, None Ring
Journal: British Journal of Dermatology (1998)

Valid questions for atopic eczema are necessary to identify risk factors in epidemiological studies. We have examined the influence of cultural and educational factors on the validity of some questions on atopic eczema used in the International Study of Asthma and Allergies in Childhood by using data from a cross-sectional study on 1511 children aged 6 years from East and West Germany. We tested three questions in relation to a point prevalence of atopic eczema as recorded by a dermatologist: (i) has a physician ever diagnosed eczema in your child? (ii) Has your child ever had an itchy rash which came and went for at least 6 months? (iii) Has your child ever had 'neurodermatitis' (atopic eczema, endogenous eczema)? The point prevalence of atopic eczema on the day of investigation was 11.1% (134 of 1217). According to the questionnaire, 15.7% of the children had had physician-diagnosed eczema, 14.1% had had neurodermatitis and 11.3% had had an itchy rash for > 6 months. Fifty-one per cent of parents who had a child with atopic eczema on the day of investigation said that their child had had an itchy rash which came and went for at least 6 months. This sensitivity value is less than that found in another community survey conducted in the U.K., suggesting that the German wording of the question seems to mean something more severe to the parents than the English one. The education of the parents had an influence on the validity of the three questions: parents with < 10 years of schooling often answered symptom and diagnosis questions less positively. Parents with academic degrees, contrary to expectation, did not answer most precisely, this being especially true for the symptom questions. The association between symptom questions and clinical diagnosis was higher in West than in East Germany. We compared lifetime eczema symptoms and diagnosis with a point prevalence clinical diagnosis. In the absence of knowledge of how extraneous factors measured in this paper can affect diseases chronicity, it is difficult to say with certainty that such factors affect the validity of symptom and diagnosis questions on atopic eczema. Our study suggests that more studies are needed to examine the influence of social class, education and location on the validity of symptom questionnaires for atopic eczema. Until then, we recommend that information about such variables should be gathered routinely.
Abstract 305: Remote Ischemic Postconditioning Alone and Combined with Therapeutic Hypothermia Improve Neurological Outcomes After Cardiopulmonary Resuscitation in a Porcine Model
Authors: Jiefeng Xu, Sen Ye, Zilong Li, Moli Wang, Zhengquan Wang, Guofeng Chen, Wanchun Tang
Journal: Circulation (2014)

Introduction: The degree of post-resuscitation cerebral injury is an important determinant on the outcomes for CA victims.We previously demonstrated remote ischemic pre- and post-conditioning equally attenuated post-CPR cerebral dysfunction in a rat model. Here we investigated the effects of remote ischemic post-conditioning (RIpostC) alone and combined with therapeutic hypothermia (TH) on the neurological outcomes after CPR. Hypothesis: RIpostC would improve post-CPR neurological function and cerebral injury, which would be enhanced by its combination with TH. Methods: Twenty-one male domestic pigs weighing 37 ± 2 kg were subjected to 10 mins of untreated VF followed by 5 mins of CPR. The animals were randomized to RIpostC, RIpostC+TH or control. Coincident with the start of CPR, RIpostC was induced by four cycles of 5 mins of limb ischemia followed by 5 mins of reperfusion. At 5 mins after resuscitation, TH was implemented by surface cooling to reach a temperature of 32-34 °C until 4 hrs post-resuscitation, followed by a rewarming rate of 1°C/h for 4 hrs. The resuscitated animals were observed for 72 hrs. Results: Six of the seven animals in each group were successfully resuscitated. Significantly better neurological function was observed in the RIpostC group than in the control group. Surprisingly the combined RIpostC and TH further improved post-CPR neurological function, which was significantly better than that in the RIpostC and control groups. There was less cerebral injury in the animals that received RIpostC alone and combined with TH; which was significantly better at 48 and 72 hrs post-resuscitation when compared to the control group. Furthermore, significantly less cerebral injury was measured at 72 hrs in the combination group than in the RIpostC group (Table). Conclusion: In a porcine model of CA, RIpostC significantly improved post-resuscitation neurological function and cerebral injury. Its combination with TH further enhanced its protective effects
Still Life With Queen
Authors: M. Therese Southgate
Journal: JAMA (2001)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Abstract P003: Distribution of Ideal Cardiovascular Health Metrics in US and Non-US populations: A Meta-Analysis of Proportions
Authors: Adnan Younus, Ehimen Aneni, Oluseye Ogunmoroti, Omar Jamal, Shozab Ali, Sameer Shaharyar, Muhammad Aziz, Rehan Malik, Rameez Ahmad, Chukwuemeka Osondu, Lara Roberson, Janisse Post, Theodore Feldman, Wasim Maziak, Arthur S Agatston, Emir Veledar, Khurram Nasir
Journal: Circulation (2015)

Introduction: With the development of new health metrics to define ideal cardiovascular health (CVH), several studies have examined the distribution of the American Heart Association (AHA) 2020 ideal CVH metrics both within and outside the United States (US). In this meta-analysis of proportions, we synthesized available data on ideal CVH metrics distribution in US cohorts and compared them with non-US populations. Methods: A MEDLINE database search was conducted using relevant free text terms such as “life’s simple 7”, “AHA 2020”, “American Heart Association 2020” and “ideal cardiovascular health” between January 2000 and October 2014. Studies were included in the meta-analysis if the proportions achieving ideal for 0, 1, 2, 3, 4, 5 or ≥6 ideal CVH metrics were known or could be estimated. A meta-analysis of proportions was conducted for US and non-US studies using a random effect model (REM). REM models were chosen because of the significant heterogeneity among studies. Results: Overall the pooled data consisted of 10 US cohorts with a total population of 94,761 participants and 6 non-US cohorts with a total of 130,242 participants. The table shows the pooled prevalence of ideal CVH factors in this population. Overall the pooled estimates of US cohorts showed 15% had 0-1 ideal CVH metrics (inter-study range: 7-22%), while 3% (inter-study range: 1-10%) had 6-7 ideal CVH metrics. This is comparable to 12% (inter-study range 1-17%) and 2% (inter-study range: 1-12%) for 0-1 and 6-7 ideal CVH metrics in the non-US studies. Conclusion: The proportion of persons achieving 6 or more ideal CVH metrics in both US and non-US cohorts is very low and the distribution of CVH metrics is similar in both US and non-US populations. Considering the strong association with worse outcomes, a coordinated global effort at improving CVH should be considered a priority.
Abstract 18072: Effect of Pregnancy on Structural Valve Deterioration of Bioprosthetic Valves: a Systematic Review and Meta-analysis
Authors: Jerson Munoz-Mendoza, Veronica A Pinto Miranda, Leonardo J Tamariz, Cesar E Mendoza
Journal: Circulation (2014)

Background: In the 1980s case series suggested that pregnancy may hasten structural valve deterioration (SVD) of bioprosthesis; however, later studies have had discordant results. We conducted a meta-analysis to determine if SVD is more common in women who become pregnant after bioprosthesis implantation and identify predictors of this association.

Methods: Using the search terms “structural valve deterioration”, “structural valve degeneration”, and “pregnancy”, MEDLINE, EMBASE, CINAHL, and Cochrane Library databases were reviewed from inception till October 2013. Cohort and case control studies assessing SVD in women of childbearing age with bioprosthesis were included. We calculated the relative risk (RR) and 95% confidence interval (CI) of having SVD by pregnancy status using the DerSimonian-Laird method. Meta-regression examined the RR of SVD by age, number of pregnancies and time from valve replacement to delivery.

Results: Our search strategy yielded 23 articles; 7 studies met our selection criteria, including a total of 856 patients. Group 1 consisted of 234 women who had been pregnant and Group 2 of 622 who had not. The RR of having SVD of Group 1 was 1.73; 95% CI 1.22-2.43; p<0.01 (Figure). None of the factors evaluated in meta-regression were statistically significant, however less pregnancies and less time from replacement to delivery had a trend towards significance.

Conclusion: Pregnancy does increase the risk of SVD. Pregnancy in women with bioprosthesis is carried out with increased risk of morbidity related to the implanted valve.

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Abstract 3722: Multimodality Cardiovascular Imaging Detects Improvment Of Subclinical Microvascular Dysfunction With Continuous Positive Airway Pressure Therapy In Obstructive Sleep Apnea Patients: A Prospective, Randomized, Double-blinded Study
Authors: Chandra Katikireddy, Patricia Nguyen, Christine Won, Chia-Yu Cardell, Deborah Nichols, Eileen Leary, Michael McConnell, Tyson H Holmes, Clete A Kushida, Phillip Yang
Journal: Circulation (2007)

Background: Several observational studies suggest that obstructive sleep apnea (OSA) is associated with an increased risk of cardiovascular disease. However, there is little data on early subclinical development of cardiovascular disease in OSA patients. Hypothesis: We tested the hypothesis that continuous positive airway pressure (CPAP) improves subclinical cardiovascular disease in OSA patients. Methods: Sixteen consecutive patients diagnosed with moderate to severe OSA were recruited into a double-blinded, prospective study. Multimodality cardiovascular imaging (CVI) studies (cardiac MRI, echocardiography, and vascular ultrasound) were performed to assess LV mass, LV and RV ejection fraction (EF), adenosine stress myocardial perfusion reserve (MPR), nitroglycerin mediated coronary vasoreactivity, and flow-mediated vasodilatation (FMD) of the brachial artery. Patients were randomized to either CPAP or sham CPAP therapy and monitored for compliance during the entire period of treatment. After 3 months of therapy, they underwent follow-up CVI studies to assess development of subclinical cardiovascular disease. Results: MPR significantly improved (p=0.02) in patients with CPAP therapy compared to those without. Similarly, FMD of brachial artery improved significantly (p=0.04) following CPAP therapy. No significant differences were observed in LV mass (p=0.31), LV EF (p=0.17), RV EF (p=0.09), LV diastolic function (E/A) (p=0.67), and coronary vasoreactivity (p=0.25) between the two groups. Conclusions: Impairment of endothelial dependent FMD, and MPR, surrogate markers of microvascualr function, has been shown to be the subclinical cardiovascular effects in OSA patients. Our findings suggest that CPAP therapy may prevent the progression of subclinical cardiovascular disease in OSA patients.
Epidemiological and virological characteristics of symptomatic acute hepatitis E in Greater Cairo, Egypt
Authors: E. Delarocque-Astagneau, F. Abravanel, A. Moshen, L. Le Fouler, R.R. Gad, M. El-Daly, E.M. Ibrahim, S. El-Aidy, T. Lashin, M. El-Hoseiny, J. Izopet, M.K. Mohamed, A. Fontanet, M. Abdel Hamid
Journal: Clinical Microbiology and Infection (2011)
Correlation between vitamin D, parathormone, creatinine and functional capacity of patients with end stage renal disease
Authors: América Fracini, Hugo Abensur, Renata Hasue, Silvia João, Carolina Fu
Journal: European Respiratory Journal (2013)

Background: It is not clear how functional capacity status is related to serum concentrations of vitamin D, creatinine or parathormone on patients in haemodialysis. Objective: To correlate serum vitamin D, parathormone and creatinine levels with functional capacity on subjects with chronic kidney failure on haemodyalisis treatment.  Methods: 15 patients in stage 5 of chronic kidney disease in haemodialysis for more than 3 months, 3 times a week, were assessed through Health Assessment Questionnaire, Six minute walk test (6MWT), Sit-to-stand test, handgrip power measurement and body mass index (BMI). Serum vitamin D, parathormone and creatinine levels were obtained in the same day of the functional tests (before first session of haemodialysis of the week). Data was analyzed with SPSS® Statistics software. We used descriptive analysis and Spearman test to correlate vitamin D, parathormone (PTH) and creatinine levels to functional capacity tests.  Results: Six men and nine women with 44,3±17,1 years and BMI 25,0±7,0. Statistical significance correlation was found between BMI and PTH (p value 0,006), 6MWT and PTH (p value 0,034). No other relations were found between functional capacity tests and serum concentrations of vitamin D, creatinine and PTH.  Conclusions: High levels of PTH serum concentration seem to have more influence on functional and physical capacity than other isolated substrates and therefore, it is an important factor to consider on clinical practice in order to predict functionality loss in patient with kidney failure.
Experts Point to Lessons Learned From Controversy Over Rofecoxib Safety
Authors: Tracy Hampton
Journal: JAMA (2005)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Abstract 12371: The Association Between Urinary Calculi and Increased Future Cardiovascular Events
Authors: Chien-Yi Hsu, Po-Hsun Huang, Hsin-Bang Leu, Jaw-Wen Chen, Shing-Jong Lin
Journal: Circulation (2014)

Introduction: Although accumulating evidence suggests urinary calculi may increase the risk of cardiovascular disease (CVD), the number of longitudinal studies linking urolithiasis to cardiovascular events is limited.

Hypothesis: We investigated the association between urinary calculi and the risk of development of myocardial infarction (MI) and/or stroke in a nationwide, population-based cohort database in Taiwan.

Methods: Our analyses were conducted using information from a random sample of 1 million people enrolled in the nationally representative Taiwan National Health Insurance Research Database. A total of 81,546 subjects aged 18 years or above, including 40,773 subjects diagnosed with urinary calculi during the study period and a propensity score-matched 40,773 subjects without urinary calculi were enrolled in our study.

Results: During a 10-year follow-up period, 501 MI events (0.61%) and 1,295 stroke events (1.59%) were identified. By comparison, the urinary calculi group had a higher incidence rate of MI occurrence (11.79 vs 8.94 per 104 person-years) and stroke (31.41 vs 22.45 per 104 person-years). Cox proportional hazard regression model analysis showed that development of urinary calculi was independently associated with higher risk of developing future MI (HR, 1.31; 95% CI, 1.09-1.56, p=0.003), stroke (HR, 1.39; 95% CI, 1.24-1.55, p<0.001), and total cardiovascular events (HR, 1.38; 95% CI, 1.25-1.51, p<0.001).

Conclusions: Urinary calculi were associated with an increased risk of future cardiovascular events.
Extracorporeal photochemotherapy in long-term treatment of early stage cutaneous T-cell lymphoma
Authors: P. Rubegni, G. De aloe, M. Fimiani
Journal: British Journal of Dermatology (2000)

Journal Article Extracorporeal photochemotherapy in long‐term treatment of early stage cutaneous T‐cell lymphoma Get access P. Rubegni, P. Rubegni Department of Dermatology, University of Siena, Italy (Istituto di Scienze Dermatologiche, Universit† degli Studi di Siena, Policlinico 'Le Scotte', Viale Bracci, 53100‐Siena, Italy) Correspondence: Dr Pietro RubegniE‐mail: rubegni@unisi.it Search for other works by this author on: Oxford Academic Google Scholar G. De aloe, G. De aloe Department of Dermatology, University of Siena, Italy (Istituto di Scienze Dermatologiche, Universit† degli Studi di Siena, Policlinico 'Le Scotte', Viale Bracci, 53100‐Siena, Italy) Correspondence: Dr Pietro RubegniE‐mail: rubegni@unisi.it Search for other works by this author on: Oxford Academic Google Scholar M. Fimiani M. Fimiani Department of Dermatology, University of Siena, Italy (Istituto di Scienze Dermatologiche, Universit† degli Studi di Siena, Policlinico 'Le Scotte', Viale Bracci, 53100‐Siena, Italy) Correspondence: Dr Pietro RubegniE‐mail: rubegni@unisi.it Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 143, Issue 4, 1 October 2000, Pages 894–896, https://doi.org/10.1046/j.1365-2133.2000.03857.x Published: 01 October 2000
DRUG REACTIONS XV.
Authors: John Almeyda, David Barnardo, Harvey Baker
Journal: British Journal of Dermatology (1971)

Journal Article DRUG REACTIONS XV: Methotrexate, Psoriasis and the Liver Get access John Almeyda, John Almeyda The London Hospital, London, E.1 Search for other works by this author on: Oxford Academic Google Scholar David Barnardo, David Barnardo The London Hospital, London, E.1 Search for other works by this author on: Oxford Academic Google Scholar Harvey Baker Harvey Baker The London Hospital, London, E.1 Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 85, Issue 3, 1 September 1971, Pages 302–305, https://doi.org/10.1111/j.1365-2133.1971.tb07237.x Published: 01 September 1971
The DNA repair gene MBD4 (MED1) is mutated in human carcinomas with microsatellite instability
Authors: Antonio Riccio, Lauri A. Aaltonen, Andrew K. Godwin, Anu Loukola, Antonio Percesepe, Reijo Salovaara, Valeria Masciullo, Maurizio Genuardi, Maria Paravatou-Petsotas, Daniel E. Bassi, Bruce A. Ruggeri, Andres J.P. Klein-Szanto, Joseph R. Testa, Giovanni Neri, Alfonso Bellacosa
Journal: Nature Genetics (1999)
Abstract 16784: Doxycycline Modulates Cardiomyocyte Remodeling in Light Chain-Induced Cardiac Amyloidosis
Authors: Richard M Wilson, David C Seldin, Flora Sam
Journal: Circulation (2014)

Cardiac amyloidosis due to clonal immunoglobulin light chain (AL) is a potentially fatal disease. The mechanism(s) of cardiac dysfunction and myocardial damage caused by amyloid fibrils deposition represents the least understood aspect of amyloid pathology. Once diagnosed with heart failure (HF), the median survival of AL cardiac amyloidosis (ALCMP) patients is &lt;6months if left untreated. However, only a minority of ALCMP patients are eligible for definitive therapy which includes autologous stem cell transplant and high dose melphalan. Despite this most patients continue to have evidence of HF and marked LVH on echocardiogram without regression even when this aggressive regimen is successful. Extracellular matrix turnover is implicated in the pathogenesis of ALCMP. Increased matrix metalloproteinase (MMP) activity may contribute to ALCMP. Doxycycline (DOX), an MMP inhibitor, reduces fibril formation and aggregates in murine models of AL and TTR amyloidosis. Autophagy plays a role in adverse cardiac remodeling, but it is unknown if LC deposition causes cardiomyocyte autophagy. We sought to test the hypothesis that DOX modulates LC-induced cardiac dysfunction and whether autophagy is part of the pathogenesis of the disease. Isolated adult rat cardiomyocytes were exposed to AL-LC (20μg/mL) or control LC (20μg/mL). MMP activities, proteins and intracellular signaling molecule expressions were measured. AL-LC increased MMP-2 (28±8%) and MMP-9 (25±6% P&lt;0.05 for both) activities. U0126, a MEK/ERK inhibitor, blocked these increases, suggesting that the MAPK pathway is involved. DOX also decreased MMP-9 (-35±6%) and MMP-2 (-35±6% P&lt;0.001 for both) activities vs AL-LC alone. AL-LC increased LC3II:LC3I protein expression ratio by 112±11% and ROS-regulated ATG4B expression by 156±13% (P&lt;0.05 vs control for both). DOX decreased AL-LC induced LC3II:LC3I ratio by 42±8% (P=0.05) but did not significantly modulate ATG4B expression vs AL-LC. Thus, AL-LC induces autophagy and MMP-2 and MMP-9 activities in cardiomyocytes, which is modulated by DOX via a MEK/ERK pathway. Since ATG4B is not involved it may be independent of ROS. These pathways may provide potential targets for future therapeutic interventions for this near fatal form of cardiomyopathy.