INCREASING CLINICAL SIGNIFICANCE OF ALTERATIONS IN ENZYMES OF BODY FLUIDS
Authors: F WROBLEWSKI
Journal: Annals of Internal Medicine (1959)

Article1 January 1959INCREASING CLINICAL SIGNIFICANCE OF ALTERATIONS IN ENZYMES OF BODY FLUIDSFELIX WRÓBLEWSKI, M.D.FELIX WRÓBLEWSKI, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-50-1-62 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptINTRODUCTIONAn inestimable wealth of biochemical information dealing with the measurement, characterization and distribution of tissue enzymes has accrued over the years. These archives include studies of crystalline enzymes derived from liver, muscle and other animal tissues, enzyme activities of tissue homogenates, intracellular enzyme localization by histochemical technics, and enzymatic patterns in the cellular and other components of body fluids. Although for some time medical science has put to clinical use basic enzyme information dealing with alkaline and acid phosphatase,1, 2, 3amylase,4lipase4and thrombin,5recent years have seen an increasing tendency to translate fundamental enzyme knowledge into clinical...Bibliography1. GutmanSproulGutman EBEEAB: Significance of increased phosphatase activity of bone at the site of osteoplastic metastases secondary to carcinoma of the prostate gland, Am. J. Cancer 28: 485-495, 1936. CrossrefGoogle Scholar2. GutmanTysonGutman ABTLEB: Serum calcium, inorganic phosphorus and phosphatase activity; in hyperparathyroidism, Paget's disease, multiple myeloma, and neoplastic disease of bones, Arch. Int. Med. 57: 379-413, 1936. CrossrefGoogle Scholar3. Woodard HQ: Factors leading to elevations in serum acid glycerophosphatase, Cancer 5: 236-241, 1952. CrossrefMedlineGoogle Scholar4. SterkelKirsner RLJB: The laboratory diagnosis of pancreatic disease, Arch. Int. Med. 101: 114-129, 1958. 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Y.*Presented as a Morning Lecture at the Thirty-ninth Annual Session of The American College of Physicians, Atlantic City, New Jersey, May 2, 1958.From the Department of Medicine of Memorial Hospital, and the Division of Enzyme and Metabolic Studies of the Sloan-Kettering Institute of Memorial Center for Cancer and Allied Diseases, New York.Requests for reprints should be addressed to Felix Wróblewski, M.D., Memorial Center for Cancer and Allied Diseases, 444 East Sixty-eighth Street, New York 21, N. Y. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byEpstein-Barr VirusEpstein-Barr VirusEpstein-Barr VirusEpstein—Barr VirusCerebrospinal Fluid Enzymes in Neurological DiseaseCerebrospinal Fluid Markers of Central Nervous System Radiation and Chemotherapy DamageEpstein-Barr VirusEpstein-Barr VirusPersistence of Transaminase Abnormalities in Former Drug AddictsCHARLES E. CHERUBIN, M.D., F.A.C.P., SETH KANE, B.A., DANIEL R. 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VOSTI, M.D., HOWARD ROFFWARG, M.D.AMBULANCESISOENZYMESThe serum proteins in kwashiorkorIsoenzymes and Myocardial InfarctionThe Electrophoretically Distinct Forms of Mammalian Lactic DehydrogenaseEnzyme Determinations in Neurologic and Neuromuscular Diseases of Infancy and ChildhoodEditorialsEnzymes in Clinical MedicineEnzymes in Clinical MedicineSerum alkaline phosphatase activity in diseases of the skeletal and hepatobiliary systemsTHE USE OF IPRONIAZID IN THE TREATMENT OF DEPRESSIVE STATES 1 January 1959Volume 50, Issue 1Page: 62-93KeywordsAminotransferasesBody fluidsEnzymesHospital medicineLipasesLiverMetabolic disordersMusclesPhosphatasesTissue distribution ePublished: 1 December 2008 Issue Published: 1 January 1959 PDF downloadLoading ...