Primary Aplastic Anemia; A Discussion and Report of Two Cases
Authors: James B. Carey, Joseph H. Taylor
Journal: Annals of Internal Medicine (1931)

Article1 October 1931Primary Aplastic Anemia; A Discussion and Report of Two CasesJAMES B. CAREY, M.D., F.A.C.P., JOSEPH H. TAYLOR, M.D.JAMES B. CAREY, M.D., F.A.C.P.Search for more papers by this author, JOSEPH H. TAYLOR, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-5-4-471 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThere are various toxic and chemical agents, which may so affect the bone marrow that it is incapable of forming blood elements, and a condition of profound anemia may therefore occur. Infectious diseases, which progress to severe stages of toxicity or septicemia; benzol; trinitrotoluene; arsenic; roentgen rays and radium emanations can all affect the hematopoietic system in such a manner as to produce the clinical picture of an aplastic anemia. In certain chronic blood disorders and malignancy, there often occurs an exhaustive aplasia of the blood-forming tissues.Excluding all known etiologic factors, however, there remains the primary or idiopathic case....References1 EHRLICH P: Ueber einen Fall von Anämie mit Bemerkungen über regenerative Veränderungen des Knochenmarks, Charité Ann., 1888, viii, 300. Google Scholar2 PAPPENHEIM A.: Pathologie, Symptomatologie und Therapie der Anämien und hemorrhagischen Diathesen, Folia haemat., 1912, xiii (2), 75. Google Scholar3 SCHNEIDER JP: Idiopathic aplastic anemia, Am. Jr. Med. Sc., 1918, clvi, 799. CrossrefGoogle Scholar4 SHEARD A: Pernicious anemia and aplastic anemia, 1924, Wm. Wood & Co. Google Scholar5 WILLIAMS EC: Two cases of aplastic anemia, Lancet, 1921, ii, 74. CrossrefGoogle Scholar6 LEVI E: Case of aplastic anemia, Gazz. d'osp., 1921, xlii, 487. Google Scholar7 FONTAINE BW: Aplastic anemia: differential diagnosis of anemias due to hemolysis and due to hemopoietic degeneration, South. Med. Jr., 1923, xvi, 495. CrossrefGoogle Scholar8 DYKE SC: Some cases of aleukia or aplastic anemia associated with thrombopenia, Lancet, 1924, i, 1048. CrossrefGoogle Scholar9 FABERI M: Roentgen-ray treatment of aplastic anemia, Policlinico, 1924, xxxi, 1229. Google Scholar10 FLEMINGDAVIDSON RAJ: Aplastic anemia, Trans. Med.-Chir. Soc., Edinburgh, 1923, xxxviii, 41-45. Edinburgh Med. Jr., 1924, xxi, 41. Google Scholar11 FLEMINGDAVIDSON RAJ: Case of myelogenous leukemia and case of aplastic anemia, Brit. Med. Jr., 1922, ii, 1074. Google Scholar12 YOUNG FW: Aplastic anemia, Ill. Med. Jr., 1925, xlvii, 142. Google Scholar13 DENECKE G: Remarkable case of aplastic anemia, Deutsch. Arch. f. klin. Med., 1926, cl, 266. Google Scholar14 KINGSBURY JG: Primary aplastic anemia, Guy's Hosp. Rep., 1926, lxxvi, 85. Google Scholar15 CABOT R: Case 13101, An obscure anemia, Bost. Med. and Surg. Jr., 1927, cxcvi, 404. CrossrefGoogle Scholar16 STOTZIKGALPERIN NA: Aplastic anemia, Russk. Klin., 1927, vii, 716. Google Scholar17 FOURNIERGARRAROCCAMONESTIER JCAFJ: Case of aplastic anemia, Bull. et Mem. Soc. méd. d'hôsp. de Paris, 1928, lii, 190. Google Scholar18 VAN PAASSEN P: Case of aplastic anemia, Nederl. Tijdschr. v. Geneesk, 1928, ii, 3378. Google Scholar19 VAN PAASSEN P: Aplastic anemia, six cases, Nederl. Tijdschr. v. Geneesk, 1928, i, 2164. Google Scholar20 LOMBARD P: Anemie aplastique, Arch. Med. Belges, 1923, lxxxi, 331. Google Scholar21 CONNER HM: Acute aplastic anemia, report of case, Proc. Staff Mayo Clinic, 1928, iii, 139. Google Scholar22 MCGOWAN JP: Further contribution to subject of aplastic anemia, Proc. Roy. Soc. Med., 1928, xxi, 33. Google Scholar23 SABRAZESMICHELEAUMANDILLON JPG: Myélose globale aplastique avec monocytose; anemie grave progressive avec leucopenie, thrombopenie, diminution du nombre des grands monocytes, modifications profondes de la moelle osseuse sternale prelevée "intra vitam," Arch. d. mal. de coeur, 1928, xxi, 656. Google Scholar24 EDIE EB: Primary aplastic anemia, liver treatment without effect, Penn. Med. Jr., 1929, xxxii, 50. Google Scholar25 DUKE WW: Aplastic anemia, Jr. Am. Med. Assoc., 1928, xci, 720. CrossrefGoogle Scholar26 DUKE WW: The pathogenesis of purpura hemorrhagica with especial reference to the part played by blood platelets, Arch. Int. Med., 1912, x, 445. CrossrefGoogle Scholar27 DUKE WW: The relation of blood platelets to hemorrhagic disease, Jr. Am. Med. Assoc., 1910, lv, 1185. CrossrefGoogle Scholar28 SONNENFELD A: Zur Frage der aplastischen Anämie, Klin. Wchnschr., 1928. vii, 1585. CrossrefGoogle Scholar29 BECART A: Remarques sur l'anemie pernicieuse et l'anemie aplastique, Presse Med., 1927, xxxv, 1538. Google Scholar30 MURPHYMCEACHERN FDJM: Aplastic anemia, Wisc. Med. Jr., 1926, XXV, 431. Google Scholar31 MCELROY JB: Differentiation of aplastic anemia and essential thrombocytopenia; its importance from therapeutic standpoint, South Med. Jr., 1926, xix, 325. CrossrefGoogle Scholar32 MARSH HE: Aplastic anemia, Ann. Clin. Med., 1924, iii, 162. Google Scholar33 GORKE H: Das Verhalten der Milz und des Knochenmarks und die Aussichten der Splenectomie bei der aplastischen Anämie, Deutsch. Arch. f. klin. Med., 1923, cxxxvi, 143. Google Scholar34 FALCONERMORRIS EHLM: Clinical comparisons of aplastic anemia, idopathic purpura haemorrhagica and aleukemic leukemia based on studies of bone marrow, Med. Clin, N. Am., 1922, vi, 353. Google Scholar35 HIRSCHFIELD H: Ueber aplastische Anämie, Folia haemat., 1911, xii (1), 347. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Minneapolis, Minn.*From the Department of Medicine, The Nicollet Clinic. Read before the Minnesota Society of Internal Medicine, April 13, 1931.†Received for publication, April 14, 1931. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byRed-Cell Abnormalities and Haemolysis in Aplastic Anaemia 1 October 1931Volume 5, Issue 4Page: 471-477KeywordsAnemiaAplastic anemiaArsenicBloodBone marrowInfectious diseasesSepsisToxic agentsToxicity ePublished: 1 December 2008 Issue Published: 1 October 1931 PDF downloadLoading ...