A Variant Form of Hypergranular Promyelocytic Leukemia (M3)
Authors: J. M. BENNETT
Journal: Annals of Internal Medicine (1980)

Letters1 February 1980A Variant Form of Hypergranular Promyelocytic Leukemia (M3)J. M. BENNETT, M.D., D. CATOVSKY, M.D., M. T. DANIEL, M.D., G. FLANDRIN, M.D., D. A. G. GALTON, M.D., H. R. GRALNICK, M.D., C. SULTAN, M.D., HARVEY R. GRALNICK, M.D.J. M. BENNETT, M.D.Search for more papers by this author, D. CATOVSKY, M.D.Search for more papers by this author, M. T. DANIEL, M.D.Search for more papers by this author, G. FLANDRIN, M.D.Search for more papers by this author, D. A. G. GALTON, M.D.Search for more papers by this author, H. R. GRALNICK, M.D.Search for more papers by this author, C. SULTAN, M.D.Search for more papers by this author, HARVEY R. GRALNICK, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-92-2-261 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: In 1976 we published proposals for the morphologic classification of the acute leukemias with descriptions of each named entity (1). The description of hypergranular proleukemia (M3 in the classification) was as follows: [1] The great majority of cells are abnormal promyelocytes, with a characteristic pattern of heavy granulation. [2] The nucleus varies greatly in size and shape and is often reniform or bilobed. [3] The cytoplasm of most of the cells is completely occupied by closely packed or even coalescent large granules staining bright pink, red, or purple by Romanovsky dyes. In some cells the cytoplasm is...References1. BENNETT J, CATOVSKY C, DANIEL M, FLANDRIN G, GALTON D, GRALNICK H, and SULTAN C. Proposals for the classification of the acute leukaemias. Br J Haematol. 1976;33:451-8. CrossrefMedlineGoogle Scholar2. GALTON D, DACIE J, and PETO R. The relation between morphology and other features of acute myeloid leukaemia and their prognostic significance: report of the Medical Research Council's Working Party on leukaemia in adults. Br J Haematol. 1975;31(suppl):165-180. Google Scholar3. TESTA J, GOLOMB H, ROWLEY J, VARDIMAN J, and SWEET D. Hypergranular promyelocytic leukemia (APL): cytogenetic and ultrastructural specificity. Blood. 1978;52:272-80. CrossrefMedlineGoogle Scholar4. BERGER R, BERNHEIM A, DANIEL M, VALENSI F, FLANDRIN G, and BERNARD J. Translocation t (15;17), leucemie aigue promyelocytaire et non promyelocytaire. Nouv Rev Fr Hematol 1979;21:117-31. MedlineGoogle Scholar5. VAN DEN BERGHE H, LOUWAGIE A, BROECKAERT-VAN ORSHOVEN A, DAVID G, VERWILGHEN R, MICHAUX J, and SOKAL G. Chromosome abnormalities in acute promyelocytic leukemia (APL). Cancer. 1979;43:558-62. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: J. M. BENNETT, M.D.; D. CATOVSKY, M.D.; M. T. DANIEL, M.D.; G. FLANDRIN, M.D.; D. A. G. GALTON, M.D.; H. R. GRALNICK, M.D.; C. SULTAN, M.D.; HARVEY R. GRALNICK, M.D.Affiliations: Hematology Service Clinical Center National Institutes of Health Bethesda, MD 20505 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited bySimple, rapid and accurate molecular diagnosis of acute promyelocytic leukemia by loop mediated amplification technologyHistorical perspectives on myelodysplastic syndromesPML-RARα and Dnmt3a1 Cooperate in vivo to Promote Acute Promyelocytic LeukemiaDifferentiation syndrome in patients with acute promyelocytic leukemia treated with all-trans retinoic acid and anthracycline chemotherapy: characteristics, outcome, and prognostic factorsCauses and prognostic factors of remission induction failure in patients with acute promyelocytic leukemia treated with all-trans retinoic acid and idarubicinTreatment of Acute Promyelocytic Leukemia by RetinoidsTreatment concepts of acute promyelocytic leukemiaTreatment With All- Trans Retinoic Acid and Anthracycline Monochemotherapy for Children With Acute Promyelocytic Leukemia: A Multicenter Study by the PETHEMA GroupDifferentiation of Acute Myeloid Leukemia from B- and T-Lineage Acute Lymphoid Leukemias by Real-Time Quantitative Reverse Transcription-PCR of Lineage Marker mRNAsOutcome of Childhood Acute Promyelocytic Leukemia With All- Trans -Retinoic Acid and ChemotherapyThe epidemiology of acute promyelocytic leukaemiaMyelodysplastic syndrome after acute promyelocytic leukemia: the European APL group experienceTherapy-Related Acute Promyelocytic LeukemiaKaryotype instability between diagnosis and relapse in 117 patients with acute myeloid leukemia: implications for resistance against therapyAll trans retinoic acid in acute promyelocytic leukemiaTreatment of acute promyelocytic leukaemiaAcquired thrombophilic syndromesAll-trans retinoic acid and chemotherapy in the treatment of acute promyelocytic leukemiaAll-trans Retinoic Acid (ATRA) Differentiates Acute Promyelocytic Leukemia Cells Independently of P-Glycoprotein (P-gp) Related Multidrug ResistanceAdditional chromosomal abnormalities in patients with acute promyelocytic leukaemia (APL) do not confer poor prognosis: results of APL 93 trialDouble induction strategy including high dose cytarabine in combination with all-trans retinoic acid: effects in patients with newly diagnosed acute promyelocytic leukemiaAcute Promyelocytic Leukemia: From Morphology to Molecular LesionsMolecular Diagnosis in Pediatric Acute LeukemiasA Randomized Comparison of All Transretinoic Acid (ATRA) Followed by Chemotherapy and ATRA Plus Chemotherapy and the Role of Maintenance Therapy in Newly Diagnosed Acute Promyelocytic LeukemiaA Randomized Comparison of All Transretinoic Acid (ATRA) Followed by Chemotherapy and ATRA Plus Chemotherapy and the Role of Maintenance Therapy in Newly Diagnosed Acute Promyelocytic LeukemiaComprehensive review of adult acute myelogenous leukemia: Cytomorphological, enzyme cytochemical, flow cytometric immunophenotypic, and cytogenetic findingsRetinoids and Differentiation of Normal and Malignant Hematopoietic CellsALL- Trans Retinoic Acid and Hematopoietic Growth Factors Regulating the Growth and Differentiation of Blast Progenitors in Acute Promyelocytic Leukemia6 Treatment of acute promyelocytic leukaemiaClinical Aspects of Acute Promyelocytic Leukemia and Response to Retinoid TherapyNew Insights into the Pathogenesis of Coagulation Dysfunction in Acute Promyelocytic LeukemiaRetinoids in Cancer TreatmentChemotherapy of the LeukaemiasMicrogranular promyelocytic leukemia: A multiparameter examinationAcute promyelocytic leukemiaEvidence for a 15; 17 translocation in every patient with acute promyelocytic leukemiaAcute Myelogenous Leukemia: Current Status of Therapy in AdultsConsistent Chromosome Abnormalities in Human Leukemia and LymphomaUltrastructural characterization of de novo and secondary leukemiasControversies in the therapy of acute myelogenous leukemiaPrognostic significance of posttransfusion hepatitis and chromosomal abnormalities in adult acute nonlymphocytic leukemiaThe French-American-British Classification of the Acute Adult Myeloid Leukemias: Its Clinical RelevanceChromosome Abnormalities in Adult Acute Leukemia: Biologic and Therapeutic SignificanceSignificance of cytogenetic abnormalities in acute leukemiasAcute promyelocytic leukemia in children 1 February 1980Volume 92, Issue 2_Part_1Page: 261-261KeywordsCellsCytoplasm ePublished: 1 December 2008 Issue Published: 1 February 1980 PDF downloadLoading ...