tbuckley/cabot-search huggingface dataset:
Prognostic Importance of Ventricular Arrhythmia in Patients Treated With Percutaneous Coronary Intervention
Authors: Tullio Palmerini, Stefano De Servi, Angelo Branzi
Journal: JAMA (2009)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Extrapulmonary Activity During Perfusion Lung Imaging with Tc-99m MAA
Authors: BETTY JO A. MILLS, ARTHUR Z. KRASNOW, B DAVID COLLIER, ROBERT S. HELLMAN, ALI T. ISITMAN
Journal: Clinical Nuclear Medicine (1990)

Ventilation and perfusion lung of a patient with suspected arterial and venous emboli was consistent with a high probability for pulmonary embolism. Unusual extrapulmonary activity was also seen, raising concern for the presence of a right to left cardiac shunt or pulmonary arteriovenous communication.
PREVENTION OF PNEUMOCOCCAL PNEUMONIA BY IMMUNIZATION WITH SPECIFIC CAPSULAR POLYSACCHARIDES
Authors: Colin M. MacLeod, Richard G. Hodges, Michael Heidelberger, William G. Bernhard
Journal: The Journal of Experimental Medicine (1945)

1. Immunization of man with 0.03 to 0.06 mg. of each of the capsular polysaccharides of pneumococcus types I, II, V, and VII, given in a single subcutaneous injection, has been shown to be effective in preventing pneumonia caused by these types but not that due to heterologous types. 2. Immunity appears within a period of 2 weeks following injection of the polysaccharides. Its duration was not determined, although 6 months can be set as a minimum. 3. Immunization of alternate subjects in the population reduced greatly the incidence of pneumonia in the non-immunized. 4. The carrier rate for pneumococcus types I, II, V, and VII was lowered significantly in the immunized group as compared with the controls. It is suggested that an over-all reduction in the incidence of carriers was responsible for the lowered rates for pneumococcal pneumonia in the non-immunized group.
How's your form of address going matey! Orright?
Authors: H. Dudley, L. Baker
Journal: BMJ (1988)

azufre, and Portuguese xofre.Only in English is the ph resolutely maintained in the written language of both scientific and biblical texts.In English alchemy sulphur became widely known as one of the primary components of the universe: that which could be transmuted from solid through liquid, fire and gas, then back to solid, remaining chemically unaltered.Gower in his alchemical text of 1390 listed sulphur as "the thridde of the fowre fundamental spirits," and Chaucer held it to be one of the four primary elements, the others being "mercure" (quicksilver), "ammoniac," and "orpiment" (arsenic trisulphide).A little later, in 1627, Bacon wrote in his Natural Historie:There bee two great families of things; you may terme them by severall names; sulphureous and murcuriall, which are the chymists words.
Occlusive Auricular Thrombi
Authors: JOHN L. READ, RENO R. PORTER, SIMON RUSSI, JOSEPH R. KRIZ
Journal: Circulation (1955)

The literature on occlusive thrombi of the auricles has been reviewed in order to identify the symptom complex attributed to this condition. The clinicopathological findings are presented in four new cases which fit this symptom complex. Two cases are notable in that one is that of a ball thrombus occurring in the absence of mitral stenosis and another the first reported case of pedunculated thrombus of the right auricle.
Angels and/on Pins
Authors: K. Garth Huston
Journal: JAMA (1965)

To the Editor:—  Your editorial of Feb 8, 1965, How Many Angels on the Point of a Pin, ( JAMA  191 : 493-494) reminds me of a verse by the English neurologist, Lord Russel Brain. It was elegantly printed in a collection of his poetry entitled Poems and Verses in a small edition of 100 copies by the wellknown English printer Will Carter at his Rampant Lions Press, in 1961.  It is as follows:  PIN-UP GIRL  The old divines, when tired of reckoning sin. Counted the angels standing on a pin. The modern woman with her high-heeled shoe Shows us an angel balancing on two.
Normotensive Women With Type 2 Diabetes and Microalbuminuria Are at High Risk for Macrovascular Disease
Authors: Adrienne A.M. Zandbergen, Eric J. Sijbrands, Steven W. Lamberts, Aart H. Bootsma
Journal: Diabetes Care (2006)

The excess risk of macrovascular disease and death associated with diabetes seems higher in women than in men. The pathogenesis for this risk difference has not been fully elucidated. We investigated whether female sex was associated with macrovascular disease and death, independently of known risk factors related to type 2 diabetes, nephropathy, or retinopathy in normotensive patients with type 2 diabetes and microalbuminuria.We conducted a prospective, prolonged follow-up study of a subgroup of 67 diabetic patients (46 men and 21 women) without established cardiovascular disease who participated in a larger clinical trial. Data were collected on current and past health, medication use, blood pressure, renal function, and HbA(1c) during the follow-up period of 4.7 +/- 0.8 (means +/- SE) years. The end point was a composite of death, cardiovascular disease, cerebrovascular events, and peripheral artery disease.Of the women, eight (38.1%) met the end point compared with six (13.4%) of the men (P = 0.02 for difference in event-free survival). The hazard ratio of women relative to men was 3.19 (95% CI 1.11-9.21), which further increased after adjusting for age, systolic blood pressure, BMI, smoking, total-to-HDL cholesterol ratio, urinary albumin excretion, and retinopathy.In our study population of normotensive patients with type 2 diabetes and microalbuminuria, female sex was associated with increased risk of fatal and nonfatal cardiovascular disease, independent of the classical cardiovascular risk factors, the severity of nephropathy or presence of retinopathy, or health care utilization.
Van Gogh's Vision
Authors: Thomas Courtney Lee
Journal: JAMA (1981)

Vincent van Gogh, the Dutch postimpressionist painter, died in 1890. He was an uncommon man. Automutilation, depression, insanity, and suicide are part of his medical history. During the last few years of his life, his paintings were characterized by halos and the color yellow. Critics have ascribed these aberrations to innumerable causes, including chronic solar injury, glaucoma, and cataracts. Van Gogh may have been under the influence of digitalis intoxication and its side effects: xanthopsia and coronas. This hypothesis is based on his twice having painted his physician holding a foxglove plant; that this medicine was used in the latter part of the 19th century in the treatment of epilepsy; and that the toxic effects of digitalis may have, in part, dictated the artist's technique.
COMPARISON OF COMPUTER-DERIVED PERSONALITY PROFILE AND PROJECTIVE PSYCHOLOGICAL TEST FINDINGS
Authors: BERNARD C. GLUECK, MARVIN REZNIKOFF
Journal: American Journal of Psychiatry (1965)

A computer program of MMPI interpretations originally developed for general practitioners working in a clinic setting was modified to some extent for use with a psychiatric inpatient population. This particular program, designed for a 1401 computer, is composed of 60 statements referring to specific MMPI scales, and a number of "modifier" statements combining information from two or more scales in configural fashion. Each of the statements referring to one particular scale reflects a low, normal, mild, moderate or marked "degree of elevation" of that scale. The computer program prints the MMPI profile as well as the interpretive statements. The computer interpretive statements were contrasted with findings from batteries of projective tests administered to the same patients. The psychologists administering and interpreting the projective instruments rated each of the computer statements appearing in a patient's MMPI record on a 6-point agreement-disagreement continuum. The psychologists judged the computer interpretations to be consistent with their projective test findings a far greater number of times than would be expected by chance. The highest agreement was with computer interpretations derived from the L and Hy scales, while the lowest occurred in reference to the Pd and Pt scales. The library of computer statements was noted to be most compatible with impressions from projective tests when describing the meaning of more elevated MMPI scores. Disagreement was most prevalent in the interpretive categories attempting to cover the low and normal degrees of elevation of MMPI scale scores. Diagnosis did not appear to enter into the amount of agreement obtained. Within the group of 5 psychologist-raters participating in the study, the least experienced tended to agree most with the computer statements. In general these results indicate that computer interpretations of MMPI records yield meaningful psychological information about psychiatric patients, with an economy of professional time, and a sharp reduction in cost.
Mesodermal Pten inactivation leads to alveolar capillary dysplasia-like phenotype
Authors: Caterina Tiozzo, Gianni Carraro, Denise Al Alam, Sheryl Baptista, Soula Danopoulos, Aimin Li, Maria Lavarreda-Pearce, Changgong Li, Stijn De Langhe, Belinda Chan, Zea Borok, Saverio Bellusci, Parviz Minoo
Journal: Journal of Clinical Investigation (2012)

Alveolar capillary dysplasia (ACD) is a congenital, lethal disorder of the pulmonary vasculature. Phosphatase and tensin homologue deleted from chromosome 10 (Pten) encodes a lipid phosphatase controlling key cellular functions, including stem/progenitor cell proliferation and differentiation; however, the role of PTEN in mesodermal lung cell lineage formation remains unexamined. To determine the role of mesodermal PTEN in the ontogeny of various mesenchymal cell lineages during lung development, we specifically deleted Pten in early embryonic lung mesenchyme in mice. Pups lacking Pten died at birth, with evidence of failure in blood oxygenation. Analysis at the cellular level showed defects in angioblast differentiation to endothelial cells and an accompanying accumulation of the angioblast cell population that was associated with disorganized capillary beds. We also found decreased expression of Forkhead box protein F1 (Foxf1), a gene associated with the ACD human phenotype. Analysis of human samples for ACD revealed a significant decrease in PTEN and increased activated protein kinase B (AKT). These studies demonstrate that mesodermal PTEN has a key role in controlling the amplification of angioblasts as well as their differentiation into endothelial cells, thereby directing the establishment of a functional gas exchange interface. Additionally, these mice could serve as a murine model of ACD.
405. Comparison Study of Structural Determinants for AAV Liver Transduction by Domain Swapping between AAV-2 and AAV-8 Capsids
Authors: Xuan Shen, Hui Xu, Zan Huang, Theresa A. Storm, Mark A. Kay
Journal: Molecular Therapy (2005)

Use of different AAV serotypes has become a major interest in the application of recombinant AAV vectors in human gene therapy. Compared to the most extensively studied AAV-2, alternative AAV serotypes can provide additional benefits, such as enhanced transduction efficiency, higher affinity for desired targets, and evasion of immune response in repeated vector administrations. Recently AAV-8 has become a promising candidate for liver-targeted gene delivery due to its capability of unrestricted high-level transgene expression in liver. Comparison between pseudotyped AAV-2/2 and AAV-2/8 vectors indicated that the potential determinants for their contrasting liver transduction efficiencies are located within the capsids.
Ovarian Haemorrhage from Ruptured Blood Cyst
Authors: G. Chambers
Journal: BMJ (1927)

WHEN the patient whose case is here described first came undei observation he presented a smooth, soft, uniiform, resilieat swelling, aln inch anid a half in diameter, situated betwcei the right internlal malleolus and the heel.The hollows at the sides of the tendo Achillis were filled up, anid there was some fullness along the outer side of the foot.
Familial Nephrogenic Diabetes Insipidus in a Female: A Study of the Effect of Hydrochlorathiazide.
Authors: Robert M. Wilson
Journal: Annals of Internal Medicine (1964)

s1 February 1964Familial Nephrogenic Diabetes Insipidus in a Female: A Study of the Effect of Hydrochlorathiazide.Robert M. Wilson, M.D., John W. Boylan, M.D., F.A.C.P., Thomas S. Bumbalo, M.D.Robert M. Wilson, M.D.Search for more papers by this author, John W. Boylan, M.D., F.A.C.P.Search for more papers by this author, Thomas S. Bumbalo, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-60-2-337_2 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptA 13-year-old Negro girl with familial nephrogenic diabetes insipidus was treated with hydrochlorathiazide.Polyuria and polydypsia had been present since infancy, and her father and paternal grandmother had the same symptoms. Physical examination showed a normal 155-lb girl. Daily urine volumes averaged 9 liters. Urinary osmolity ranged from 60 to 100 mOsm/liter. Volume and osmolality were unaffected by pitressin or the infusion of hypertonic saline. Water deprivation decreased urine volume with only slight increase in concentration.Following a control period hydrochlorathiazide (50 mg, twice daily) caused a significant decrease in urine volume, free water clearance (CH2O) and creatinine clearance (Ccr).... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: Robert M. Wilson, M.D.; John W. Boylan, M.D., F.A.C.P.; Thomas S. Bumbalo, M.D.Affiliations: Buffalo, New York PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byDiabetes insipidus, nephrogenic type, complicating pregnancy: A case report 1 February 1964Volume 60, Issue 2_Part_1Page: 337-337KeywordsAttentionCreatinineUrineVasopressin ePublished: 1 December 2008 Issue Published: 1 February 1964 PDF downloadLoading ...
LYMPHOID HYPERTROPHY IN THE PHARYNGEAL VAULT.Read in the Section of Loryngology and Otology, at the Forty-first Annual Meeting of the American Medical Association, held at Nashville, Tenn., May, 1890.
Authors: JONATHAN WRIGHT
Journal: JAMA (1890)

It is seventeen years since Meyer, of Copenhagen, first wrote his paper on adenoid growths in the naso-pharynx. Since then the importance of the subject has grown constantly more apparent in explaining not only a set of symptoms directly dependent upon their presence, but in the understanding of a series of sequelae and of subsequent local changes. Since then also there has been such an abundance of papers more or less complete that there is little left to be said except in a discussion of details.  The subject is, however, of such importance that some points in regard to it bear repetition. One of these, which has not been dwelt on so much in this country as abroad, is the pathological anatomy and the ultimate change of the lymphoid tissue. There are few who have had the opportunity of examining the post mortem appearances of either the healthy or the
Preferential Visualization of the Inferior Vena Cava in the Dynamic Hepatic Flow Study of the Superior Vena Cava Syndrome
Authors: Hee Kyung Lee
Journal: Clinical Nuclear Medicine (1977)

A case of superior vena cava syndrome was studied with 99mTc sulfur colloid dynamic and static scintiscanning. The dynamic flow study revealed relatively early visualization of the inferior vena cava while the superior vena cava and collaterals were not visualized. The static image did not reveal a clear cut focal “hot spot” although it showed somewhat relatively increased activity in the central area.
Prospective Comparison of 99mTc-GH SPECT/CT and 18F-FDOPA PET/CT for Detection of Recurrent Glioma
Authors: Sellam Karunanithi, Guru Pada Bandopadhyaya, Punit Sharma, Abhishek Kumar, Suhas Singla, Arun Malhotra, Deepak Kumar Gupta, Chandrasekhar Bal
Journal: Clinical Nuclear Medicine (2013)

Objective This study aimed to evaluate and compare the role of 99mTc-GH SPECT/CT and 18F-FDOPA PET/CT for diagnosing recurrence in patients with glioma. Methods Thirty patients with histopathologically proven glioma (glioblastoma multiforme, 14; grade III, 6; grade II, 8; and grade I, 2), who presented with clinical and/or imaging suspicion of recurrence were prospectively evaluated. They were primarily treated with surgery and radiotherapy with or without chemotherapy. Each patient underwent 99mTc-GH SPECT/CT and 18F-FDOPA PET/CT within a span of 15 days. Images were evaluated qualitatively and quantitatively by 2 experienced nuclear medicine physicians in consensus. Histopathology and/or clinical/imaging follow-up were used as reference standard. Results Based on reference standard, 22 patients were positive and 8 were negative for recurrence. 99mTc-GH SPECT/CT was positive for recurrence in 22 and negative in 8 patients. 18F-FDOPA PET/CT scan was positive for recurrence in 23 and negative in 7 patients. Sensitivity, specificity, and accuracy were 86.4%, 62.5%, and 80% for 99mTc-GH SPECT/CT and 100%, 87.5%, and 96% for 18F-FDOPA PET/CT, respectively. No significant difference was found between 99mTc-GH SPECT/CT and 18F-FDOPA PET/CT overall (P = 1.00), as well as for low-grade (P = 0.250) or high-grade tumors (P = 0.50). Significant correlation was noted between tumor-brain of 99mTc-GH with both tumor-striatum (r = 0.371; P = 0.044) and tumor-cerebellum ratio of 18F-FDOPA (r = 0.369; P = 0.045). Conclusions For detection of recurrence in glioma patients, 99mTc-GH SPECT/CT is not inferior to 18F-FDOPA PET/CT and can be used as a low-cost alternative.
A 25-Year-Old Woman With Bipolar Disorder
Authors: Gary S. Sachs
Journal: JAMA (2001)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Feast and Famine
Authors: James E. Novak, Lynda A. Szczech
Journal: Journal of the American Society of Nephrology (2007)

In this issue of JASN , Smith et al. [1][1] demonstrate an association between chronic kidney disease (CKD) and mortality in a cohort of patients hospitalized with acute myocardial infarction (AMI). Nearly 120,000 elderly patients with AMI (mean age 76 ± 7 yr) were followed for 10 yr, and all-cause
Consortium-Based Science: The NIEHS’s Multipronged, Collaborative Approach to Assessing the Health Effects of Bisphenol A
Authors: Linda S. Birnbaum, John R. Bucher, Gwen W. Collman, Darryl C. Zeldin, Anne F. Johnson, Thaddeus T. Schug, Jerrold J. Heindel
Journal: Environmental Health Perspectives (2012)

Bisphenol A (BPA) is a high production volume chemical used to make polycarbonate plastic and is found in many consumer products. Some studies using animal models have suggested that BPA exposures may have adverse health effects. However, research gaps have precluded a full understanding of the effects of BPA in humans and engendered controversies surrounding the chemical's potential toxicity.
Liver Imaging in Hemochromatosis Secondary to Multiple Blood Transfusions
Authors: RICHARD T. TRACKLER
Journal: Clinical Nuclear Medicine (1977)

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