tbuckley/cabot-search huggingface dataset:
Ion Channels and Insulin Secretion
Authors: Arun S Rajan, Lydia Aguilar-Bryan, Daniel A Nelson, Gordon C Yaney, Walter H Hsu, Diana L Kunze, A E Boyd
Journal: Diabetes Care (1990)

We review the role of ion channels in regulating insulin secretion from pancreatic β-cells. By controlling ion permeability, ion channels at the membrane play a major role in regulating both electrical activity and signal transduction in the β-cell. A proximal step in the cascade of events required for stimulus-secretion coupling is the closure of ATP-sensitive K+ channels, resulting in cell depolarization. Of particular relevance is the finding that this channel is directly regulated by a metabolite of glucose, which is the primary insulin secretagogue. In addition, this channel, or a closely associated protein, contains the sulfonylurea-binding site. Another K+ channel, the Ca2+-activated K+ channel, may be involved in cell repolarization to create homeostasis. Voltage-dependent Ca2+ channels are activated by cell depolarization and regulate Ca2+ influx into the cell. By controlling cytosolic free-Ca2+ levels ([Ca2+]i), these channels play an important role in transducing the initial stimulus to the effector systems that modulate insulin secretion. The link between a rise in [Ca2+[(and the terminal event of exocytosis is the least-understood aspect of stimulus-secretion coupling. However, phosphorylation studies have identified substrate proteins that may correspond to those involved in smooth muscle contraction, suggesting an analogy in the processes of stimulus secretion and excitation contraction. The advent of new methodology, particulary the patch-clamp technique, has fostered a more detailed characterization of the β-cell ion channels. Furthermore, biochemical and molecular approaches developed for the structural analysis of ion channels in other tissues can now be applied to the isolation and characterization of the β-cell ion channels. This is of particular significance because there appear to be tissue-specific variations in the different types of ion channels. Given the importance of ion channels in cell physiology, a knowledge of the structure and properties of these channels in the β-cell is required for understanding the abnormalities of insulin secretion that occur in non-insulin-dependent diabetes mellitus. Ultimately, these studies should also provide new therapeutic approaches to the treatment of this disease.
Auscultatory Recognition of Aneurysm of the Membranous Ventricular Septum Associated with Small Ventricular Septal Defect
Authors: DANIEL R. PIERONI, BARBARA B. BELL, L. JEROME KROVETZ, P. JACOB VARGHESE, RICHARD D. ROWE
Journal: Circulation (1971)

The clinical diagnosis of aneurysmal formation of the membranous ventricular septum associated with a small ventricular defect has been made previously only by means of angiocardiography. Active movement of the aneurysm during cineangiocardiography suggested the possibility of a corresponding auscultatory event. When careful auscultatory and phonocardiographic examinations were performed on 21 patients previously documented as having a small membranous ventricular defect with an associated aneurysm, a distinct early systolic sound was heard in 17 (81%). This sound was "clicky" in quality, confined to a narrow area along the lower left sternal edge, and best heard in expiration. It occurred during the upstroke of the carotid arterial tracing and followed the Q wave by 100 to 130 msec. On the basis of experience with other patients the development of this early systolic sound in a patient with a small ventricular septal defect suggests the diagnosis of associated septal aneurysm, but such a sequence requires confirmation by serial angiocardiography. Aneurysmal formation may be a prelude to spontaneous closure of the septal defect in which case auscultation of an early systolic sound should not only prove to be a valuable diagnostic sign for the clinician but may also be of considerable prognostic significance for the patient.
Do you believe in God?
Authors: K. Barraclough
Journal: BMJ (1999)

As he left the consulting room he turned.

“Do you believe in God?” he asked.

He was a man in his 40s with two young children and prostate cancer.

I don't think that I answered.

He didn't, he said.

The terminal care went well until the end. But he was young, and his bodily systems did not fade gracefully as with older patients. He was restless and inadequately sedated at the end, probably through my inexperience.

He …
Abstract 365: Genetic Variants in ALOX5 and ALOX5AP are Associated with Reduced Response to Aspirin in African American Families with Premature Coronary Artery Disease
Authors: J. E Herrera-Galeano, Nauder Faraday, Lisa R Yanek, Taryn F Moy, Diane M Becker, Lewis C Becker
Journal: Circulation (2007)

Background: ALOX5 (arachidonate 5-lipoxygenase) and ALOX5AP (arachidonate 5-lipoxygenase activating protein) are involved in the production of leukotrienes, which may interact with cyclo-oxygenase to alter the formation of thromboxane. Reduced suppression of thromboxane production by aspirin (ASA) was associated with worse cardiovascular outcomes in the HOPE study. We therefore examined whether genetic variants in ALOX5 or ALOX5AP could modify the effect of ASA on thromboxane production. Methods: We measured urinary 11-dehydro-thromboxane B2 (UTX) levels after 2 weeks of ASA, 81 mg/day, in 1546 healthy individuals from 2-generational families with premature coronary heart disease (CHD) (n=573 African Americans from 120 families; n = 973 whites from 202 families). We genotyped 18 SNPs in ALOX5 and 10 SNPs in ALOX5AP with about 4 kb density. FBAT software was used to determine whether any SNPs were associated with the upper quartile of UTX (the least ASA suppression). The analysis was adjusted for known risk factors such as smoking, high blood pressure, sex, age, obesity, fibrinogen, diabetes and cholesterol. Results: We obtained significant associations between SNPs in both genes and the upper quartile of UTX in African Americans, but not in whites (Table ). The SNPs were not in linkage disequilibrium except for rs7896431 and rs901681 (r 2 =0.80) in African Americans. Conclusion: Both the ALOX5 and ALOX5AP genes have polymorphisms associated in African Americans with less suppression of UTX by ASA. The response to ASA may be affected by an interaction between the leukotriene and thromboxane pathways. Association of SNPs and the upper quartile of UTX
Value of the plasma protein and hemoglobin concentration in the diagnosis of pulmonary edema in scorpion sting patients
Authors: Mabrouk Bahloul, Mounir Bouaziz, Hassen Dammak, Chokri Ben Hamida, Hichem Ksibi, Noureddine Rekik, Hedi Chelly, Jean Teboul, Hatem Kallel
Journal: Intensive Care Medicine (2002)
Atypical Sickle Cell Anemia
Authors: Richard C. Gause
Journal: JAMA (1963)

Four patients presenting unusual manifestations of sickle cell anemia were studied. Clinical variants were age, habitus, and pregnancy. In some cases, these features were so atypical as to suggest disease entities other than sickle cell anemia and obscure the diagnosis. The recognition of a wider clinical spectrum for occasional patients with this disease seems justified.
Shortened Telomeres in Circulating Leukocytes of Patients with Chronic Obstructive Pulmonary Disease
Authors: Laurent Savale, Ari Chaouat, Sylvie Bastuji-Garin, Elisabeth Marcos, Laurent Boyer, Bernard Maitre, Mourad Sarni, Bruno Housset, Emmanuel Weitzenblum, Mireille Matrat, Philippe Le Corvoisier, Dominique Rideau, Jorge Boczkowski, Jean-Luc Dubois-Randé, Christos Chouaid, Serge Adnot
Journal: American Journal of Respiratory and Critical Care Medicine (2009)

Telomere length is considered a marker for biological aging. Chronic obstructive pulmonary disease (COPD) may be associated with premature aging.To test the hypothesis that patients with COPD experience accelerated telomere shortening and that inflammation is linked to this process.We measured telomere length, using a quantitative polymerase chain reaction-based method, and plasma levels of various cytokines in 136 patients with COPD, 113 age- and sex-matched smokers, and 42 nonsmokers with normal lung function.Median (range) telomere length ratio was significantly lower in patients with COPD (0.57 [0.23-1.18]) than in control smokers (0.79 [0.34-1.58]) or nonsmokers (0.85 [0.38-1.55]) (P < 0.001). The difference remained highly significant when using logistic regression analysis adjusted for age, sex, and tobacco exposure. Both females and males with COPD had shorter telomere length than same-sex control subjects. Telomere length was related to age in patients and control subjects but was shorter in patients than in control subjects in all age groups. No relationship was found between telomere length and tobacco exposure in patients or control subjects, with no difference between control smokers and nonsmokers. In patients with COPD, telomere length was related to PaO2 (P < 0.001) and PaCO2 (P < 0.001) but not to lung function parameters or the BODE Index. Patients with COPD also had elevated plasma levels of various cytokines, interleukin-6 correlating negatively with telomere length (P < 0.001).Given that in vivo telomere length reflects cellular turnover and exposure to oxidative and inflammatory damage, our data support accelerated aging in COPD.
MODIFIED ESMARCH ANESTHESIA MASK FOR EYE SURGERY.
Authors: PAUL DeWITT
Journal: JAMA (1907)

The need for a special anesthesia mask for operations on and about the eye has occurred to me often. The regular Esmarch inhaler is too much in the way of the operator when used in the usual manner with the handle between the eyes and does not fit the face when reversed. Recently I made the modifications shown in the cuts and have used it with the greatest satisfaction to both operator and anesthetist. A bridge for the nose (Fig. 1, A), which crosses just above the tip of the nose, leaves a clear operative field. The frame has a downward convexity (Fig. 2, B to C) of about three-fourths of an inch. This fits snugly the sides of the face, preventing pressure on the nose and closing in the spaces at the corners of the mouth, thus doing away with the folded towel often wound around the ordinary Esmarch
Abstract 3302: Roles of cortical and subventricular GFAP+ astrocytes in initiation of astrocytomas
Authors: Ralf S. Schmid, Ryan E. Bash, Andrea M. Werneke, C. Ryan Miller
Journal: Cancer Research (2012)

Abstract Astrocytomas, including glioblastomas (GBM), are characterized by cellular, molecular, and morphological heterogeneity, which raises the question from which cells astrocytomas originate. Research with many different types of cancer has established that tumor initiating cells share molecular characteristics and gene expression signatures with stem cells; however, the origin of glioma initiating cells and their relationship to adult neural stem cells remains unclear. Using conditional, inducible genetically-engineered mouse models (GEMM) with inactivated RB (GFAP-driven transgenic expression of N-terminal SV40 large T mutant (T121), T) and/or PTEN (P) and/or constitutively activated KRAS (R, KRAS(G12D)), we show that tumorigenesis was initiated in both parenchymal GFAP+ astrocytes as well as GFAP+ NSC/progenitor cells in the subventricular zone (SVZ) within two weeks of induction in adult mice. The induced GFAP+ cells proliferated (measured by EDU incorporation) and expressed multiple neural stem cell (NSC) markers such as Sox2, nestin and CD133, which persisted in developing astrocytomas over several months. Primary cortical astrocytes from TRP-/- mice cultured in vitro under NSC conditions displayed self-renewal and multi-lineage differentiation potential and expressed multiple NSC markers. When stereotactically injected in the diencephalon of syngeneic recipient mice, astrocytomas formed within 3 weeks, which histopathologically and genetically resembled human glioblastoma and proved to be fatal with a median survival of 25 days. To further evaluate the relationship between adult neural stem/progenitor cells in the SVZ and astrocytoma initiating cells, we crossed TRP GEMM with knock-in Sox2-GFP reporter mice to purify TRP neural stem cells from the SVZ. These cells were then stereotactically injected into the diencephalon of syngeneic recipient mice. Allograft cells, identified by GFP expression, were found proliferating around the injection site several weeks after injection, suggestive of developing astrocytomas. Some cells also migrated along white matter tracks and infiltrated the stem cell niche in the subventricular zone. These results suggest that GFAP+ NSC within the SVZ, and potentially GFAP+ astrocytes elsewhere in the neuraxis, may serve as the cell-of-origin for diffuse astrocytomas in the adult murine brain. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 103rd Annual Meeting of the American Association for Cancer Research; 2012 Mar 31-Apr 4; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2012;72(8 Suppl):Abstract nr 3302. doi:1538-7445.AM2012-3302
Onychomatrixoma. Filamentous tufted tumour in the matrix of a funnel-shaped nail: a new entity (report of three cases)
Authors: R Baran, André Kint
Journal: British Journal of Dermatology (1992)

Identical lesions of the nails were observed in three patients. The main signs were a yellow colouration along the entire length of the nail plate with splinter haemorrhages in its proximal portion, a tendency towards transverse overcurvature of the affected nails, and exposure of a matrix tumour after the nail had been avulsed and the proximal nail fold turned back. The nails signs were striking enough to lead to the clinical suspicion of a filamentous tufted tumour in the matrix of a funnel-shaped nail, an entity not previously described.
Increased Sacroiliac Joint Uptake after Lumbar Fusion and/or Laminectomy
Authors: CETIN ONSEL, B DAVID COLLIER, KEMAL METIN KIR, SANFORD J. LARSON, GLENN A. MEYER, ARTHUR Z. KRASNOW, ALI T. ISITMAN, ROBERT S. HELLMAN, GUILLERMO F. CARRERA
Journal: Clinical Nuclear Medicine (1992)

Of 753 adult patients undergoing SPECT and planar bone scintigraphy for the evaluation of low back pain, 43 (6%) showed either unilateral or bilateral increased sacroiliac joint (SIJ) uptake. Five of the 58 abnormal joints were only identified with SPECT (9%), whereas 20 of the 58 abnormal joints were much more convincingly demonstrated by SPECT (34%). Fifteen of the 43 patients with increased SIJ uptake had undergone prior lumbar laminectomy and/or spinal fusion. Such spinal surgery can increase impact loading on the SIJ, leading to mechanical overload and sacroiliitis. Degenerative joint disease, trauma, or other benign pathology accounted for the remaining patients with increased SIJ uptake. The authors conclude that for patients with a history of lumbar spinal fusion and/or laminectomy, increased SIJ uptake usually is caused by altered spinal mechanics rather than malignancy or infection.
Ermüdungserscheinungen in der psychoanalytischen Behandlungssituation
Authors: T.F. Hau
Journal: Psychotherapy and Psychosomatics (1966)

Research Articles| February 11 2010 Ermüdungserscheinungen in der psychoanalytischen Behandlungssituation Subject Area: Psychiatry and Psychology T.F. Hau T.F. Hau Freiburg i Br. Search for other works by this author on: This Site PubMed Google Scholar Psychother Psychosom (1966) 14 (4): 323–328. https://doi.org/10.1159/000285837 Article history Published Online: February 11 2010 Content Tools Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Facebook Twitter LinkedIn Email Tools Icon Tools Get Permissions Cite Icon Cite Search Site Citation T.F. Hau; Ermüdungserscheinungen in der psychoanalytischen Behandlungssituation. Psychother Psychosom 1 April 1966; 14 (4): 323–328. https://doi.org/10.1159/000285837 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAll JournalsPsychotherapy and Psychosomatics Search Advanced Search Article PDF first page preview Close Modal This content is only available via PDF. 1966Copyright / Drug Dosage / DisclaimerCopyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher.Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. You do not currently have access to this content.
Livestock movement and emerging zoonotic disease outbreaks: applying ecological, network, and sociocultural theories to assess the risk of Middle East respiratory syndrome from camel trade in Ethiopia and Egypt
Authors: A Roess, L Carruth, M Mann, I Kabbash, S Melaku, M Atia, M Mohamed, S Bansal, S Lahm, Y Terefe, M Salman
Journal: The Lancet Global Health (2015)

Emerging infectious diseases are associated with complex linkages within the broader ecosystem. Studying infectious disease among hosts (animals and humans), outside of the context of their environment, ignores the complexity in which hosts interact. We aimed to formulate a framework to study the effect of large livestock movement on the ecology of emerging zoonotic infectious disease in low-income and middle-income countries. Ultimately such a framework could identify points of intervention in livestock movement chains to reduce the risk of emerging diseases. As a test case, we use camel movement and Middle East respiratory syndrome coronavirus (MERS-CoV). We reviewed grey and peer-reviewed literature on camel husbandry and interviewed key stakeholders in Egypt and Ethiopia involved in public health research, animal husbandry, the camel trade, veterinary services for camels, and physicians. A multidisciplinary team consisting of wildlife biologists, anthropologists, epidemiologists, veterinarians, geographers, modellers, virologists, and health-care professionals from the USA, Egypt, and Ethiopia was assembled to propose the framework. A framework has been developed which highlights the associations between the complex linkages within the broader ecosystem: environment (flora, climate, pollution), animals (distribution and density of animals, interaction between humans, domesticated and wildlife animals), and human behavioural systems (socio-cultural and economic structures around animal husbandry and hunting, connectivity including market trade systems). While there is an emphasis on interdisciplinary cooperation in the area of one health, this type of work has several challenges. A history of interdisciplinary work in zoonotic infectious disease is limited, in part, because of the lack of undergraduate and graduate curricula that provide training. Additionally the large teams required to conduct truly interdisciplinary work require sustained funding and such opportunities are rare. None.
Present status and perspectives of cell-based therapies for liver diseases
Authors: Andreas Nussler, Sarah Konig, Michael Ott, Etienne Sokal, Bruno Christ, Wolfgang Thasler, Marc Brulport, Geredn Gabelein, Wiebke Schormann, Maren Schulze, Ewa Ellis, Matthias Kraemer, Frank Nocken, Wolfgang Fleig, Michael Manns, Steven C. Strom, Jan G. Hengstler
Journal: Journal of Hepatology (2006)
Adult-Onset Still Disease: Evaluation With Serial F-18 Fluorodeoxyglucose Positron Emission Tomography
Authors: Evelyn Vranken, Jan Versijpt, Linsey Winne, Eric M. Veys, Ham Hamphrey
Journal: Clinical Nuclear Medicine (2005)

Adult-onset Still disease (AOSD) is a rare inflammatory disease characterized by a combination of symptoms such as spiking fever (≥39°C), arthralgias and/or arthritis, cutaneous rash, sore throat, lymph node enlargement, neutrophilic leucocytosis, and disturbed liver metabolism. Before arriving at the diagnosis of AOSD, other systemic disorders such as rheumatic or infectious diseases, vasculitis, and neoplastic disorders have to be excluded. As such, a diagnostic process with conventional imaging and/or F-18 fluorodeoxyglucose positron emission tomography (FDG PET) may be indicated. In this report, we describe serial FDG PET imaging findings in a patient with systemic complaints and diagnosed with AOSD.
1043-49 Current percutaneous transluminal coronary angioplasty practice and clinical outcomes in the Netherlands: The real world
Authors: Pascalle S Monraats, Willem R.P Agema, Aeilko H Zwinderman, Robbert J de Winter, Rene A Tio, Pieter A.F.M Doevendans, Harry J.G.M Crijns, Moniek P.M de Maat, Douwe E Atsma, Arnoud van der Laarse, Ernst E van der Wall, J Wouter Jukema
Journal: Journal of the American College of Cardiology (2004)
Involvement of double-stranded RNA-dependent protein kinase and antisense viral RNA in the constitutive NFκB activation in adult T-cell leukemia/lymphoma cells
Authors: S Kinpara, S Ito, T Takahata, Y Saitoh, A Hasegawa, M Kijiyama, A Utsunomiya, M Masuda, Y Miyazaki, M Matsuoka, M Nakamura, S Yamaoka, T Masuda, M Kannagi
Journal: Leukemia (2014)
Age-Specific Incidence of Alzheimer's Disease in a Community Population
Authors: Liesi E. Hebert
Journal: JAMA (1995)

<h3>Objective.</h3> —To determine age-specific incidence rates of clinically diagnosed Alzheimer's disease. <h3>Design.</h3> —Cohort, followed a mean of 4.3 years. <h3>Setting.</h3> —East Boston, Mass. <h3>Participants.</h3> —Of 2313 persons aged 65 years and older who were initially free of Alzheimer's disease, 1601 participated in the ascertainment of incident disease (80% of survivors), 409 declined participation, and 303 died before the end of the follow-up period. A stratified sample of 642 persons received detailed clinical evaluation. <h3>Outcome Measure.</h3> —Diagnosis of new probable Alzheimer's disease through structured clinical evaluation including neurologic, neuropsychological, and psychiatric examination. Community incidence rates were computed by 5-year age groups, adjusted for gender, single year of age, length of follow-up interval, and sampling design. <h3>Results.</h3> —The estimated annual incidence of Alzheimer's disease in the population was 0.6% (95% confidence interval [Cl], 0.3% to 0.9%) for persons aged 65 to 69 years, 1.0% (95% Cl, 0.6% to 1.4%) for persons aged 70 to 74 years, 2.0% (95% Cl, 1.3% to 2.7%) for persons aged 75 to 79 years, 3.3% (95% Cl, 2.2% to 4.4%) for persons aged 80 to 84 years, and 8.4% (95% Cl, 3.7% to 13.1%) for persons aged 85 years and older. <h3>Conclusions.</h3> —The incidence of Alzheimer's disease is substantial and is approximately 14 times higher among persons older than 85 years compared with those between 65 and 69 years of age. (<i>JAMA</i>. 1995;273:1354-1359)