tbuckley/cabot-search huggingface dataset:
Abstract 3696: Effect of dietary omega-3/omega-6 ratio on mammary carcinogenesis, circulating biomarkers and molecular regulators in rats
Authors: Zongjian Zhu, Weiqin Jiang, John N. McGinley, Andrea Manni, Karam El-Bayoumy, Henry J. Thompson
Journal: Cancer Research (2011)

Abstract Available evidence indicates that diets enriched in the ratio of n-3 to n-6 fatty acids have a broad range of health-related benefit; however, the epidemiological and preclinical data for breast cancer risk are mixed. The majority of animal carcinogenesis experiments have been done using diets that were high in the percent of dietary calories provided from fat (40 to 50%) and few studies have investigated the impact of the n-3/n-6 ratio despite the fact that considerable emphasis has been placed on this ratio in hypothesized mechanisms of action. The objective of this investigation was to determine the effect of a wide range of dietary n-3/n-6 ratios on mammary carcinogenesis, on plasma levels of cancer associated growth factors and cytokines and on molecular regulators in mammary carcinomas using a pre-clinical rat model for breast cancer. Female Sprague Dawley rats were injected with 1-methyl-1-nitrosourea (50 mg/kg) and 7 days thereafter randomized to groups (n=30/group) in which the n-3/n-6 ratio varied widely and diets were fed in the presence or absence of tamoxifen treatment. Rats were fed a modification of the AIN-93G diet formulation that contained 30% of dietary calories from fat (currently recommended in the US Dietary guidelines). It was observed that mammary cancer incidence, cancer multiplicity and tumor burden were reduced when the dietary ratio of n-3/n-6 was &amp;gt; 5:1. Cancer inhibition was observed in both the presence and absence of tamoxifen. The protective dietary n-3/n-6 ratio was associated with significant reductions in plasma IGF-1, insulin, and leptin and increased adiponectin compared to rats fed the control diet (n-3/n-6=1:1, p&amp;lt;0.05), effects that were not modified by tamoxifen treatment. Carcinomas induced in the protected animals were smaller in mass with altered levels of proteins in the PPAR-NFkB pathway. This work was supported by grant KG081632 from the Susan G. Komen Foundation. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 102nd Annual Meeting of the American Association for Cancer Research; 2011 Apr 2-6; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2011;71(8 Suppl):Abstract nr 3696. doi:10.1158/1538-7445.AM2011-3696
Effect of Hematocrit Concentration on Blood Glucose Value Determined on Glucometer II
Authors: Peter B Barreau, Joseph E Buttery
Journal: Diabetes Care (1988)

Nineteen patient blood samples each with modified hematocrit concentrations of approximately 20, 30, 40, 50, and 60%, were assayed for their glucose concentration by the Glucometer II. Blood removal from the test strip was by the one- and two-blot techniques. The reference method was the Yellow Springs Instruments (YSI) blood glucose analyzer. Glucometer II results were falsely high for the single blot (13-59%, mean 33%) and double blot (12-41%, mean 19%) at 20% hematocrit and falsely low at 60% hematocrit for the single blot (22-44%, mean 37%) and the double blot (26-49%, mean 43%). At 40-50% hematocrit, Glucometer II and YSI results agreed only for the one-blot technique.
Comparison of Contrast-Enhanced Color Doppler Imaging (CDI), Computed Tomography (CT), and Magnetic Resonance Imaging (MRI) for the Detection of Crossing Vessels in Patients with Ureteropelvic Junction Obstruction (UPJO)
Authors: Michael Mitterberger, Germar M. Pinggera, Richard Neururer, Reinhard Peschel, Daniela Colleselli, Friedrich Aigner, Johann Gradl, Georg Bartsch, Hannes Strasser, Leo Pallwein, Ferdinand Frauscher
Journal: European Urology (2007)
Non-Hodgkin's Lymphoma After Treatment of Hodgkin's Disease: Association with Epstein-Barr Virus
Authors: ALAN F. LIST
Journal: Annals of Internal Medicine (1986)

Non-Hodgkin's lymphoma occurs infrequently as a late complication of obscure cause after treatment of Hodgkin's disease. We investigated the possible role of Epstein-Barr virus in the pathogenesis of such secondary malignancies of B-cell lineage. Two patients, aged 25 and 43 years, developed high-grade non-Hodgkin's lymphomas 12 and 8 years after radiation therapy for Hodgkin's disease. Serologic profiles in these patients showed evidence of acute and past Epstein-Barr virus infections, respectively. Molecular hybridization analysis showed the presence of multiple cellular equivalents of virus genome in tumor specimens from each patient. Our findings suggest that Epstein-Barr virus may play an integral role in the pathogenesis of non-Hodgkin's lymphoma of B-cell lineage that develops after treatment of Hodgkin's disease.
It's Over, Debbie
Authors: Watson Kime
Journal: JAMA (1988)

<h3>To the Editor.</h3> —I am sure there are a lot of my colleagues who may be shocked by the article entitled "It's Over, Debbie,"<sup>1</sup>but it touches on one of the central reasons I became a physician. I applaud the courage of the author to write about his humaneness, and I applaud<i>JAMA</i>'s courage in publishing it.
Replacement of the Cervical Esophagus and Hypopharynx by a Revascularized Free Jejunal Autograft
Authors: Robert E. Roberts, F. M. Douglass
Journal: New England Journal of Medicine (1961)

IT is the purpose of this paper to present a case of successful replacement of the cervical esophagus and hypopharynx with a revascularized jejunal autograft in a patient with carcinoma of the hypopharynx.Cancer of the hypopharynx and cervical esophagus has remained a major challenge to surgeons. Radiation therapy has generally not given satisfactory results, and surgical extirpation continues as the most satisfactory approach to this difficult problem. Operations in this region are usually multistaged, requiring the use of pharyngotomes,1 whereas the one-stage resections requiring the use of a split-thickness graft often result in a high incidence of complications, usually . . .
Fluticasone Furoate Decreases Nasal Eosinophilic Inflammation by Inhibiting Both Cytokine Secretion From Nasal Mucosa Epithelial Cells Cytokine Secretion and Eosinophil Survival
Authors: Jordi Roca-Ferrer, Laura Pujols, Maria Perez, Mireya Fuentes, Francisco de Borja Callejas, Isam Alobid, Antonio Valero, Cesar Picado, Joaquim Mullol
Journal: Journal of Allergy and Clinical Immunology (2013)
Expression of the mitochondrial uncoupling protein gene from the aP2 gene promoter prevents genetic obesity.
Authors: J Kopecky, G Clarke, S Enerbäck, B Spiegelman, L P Kozak
Journal: Journal of Clinical Investigation (1995)

The brown fat-specific mitochondrial uncoupling protein (UCP) provides a mechanism for generating heat by uncoupling respiration and oxidative phosphorylation. It has been suggested that this system of thermogenesis can provide a defense against obesity. To test this idea, we created a transgenic mouse in which the fat-specific aP2 gene promoter directed Ucp expression in white fat and provided for the constitutive expression of Ucp in brown fat. Transgenic mice showed both Ucp mRNA and immunoreactive UCP in white fat at 2-10% the level normally measured in brown fat. A reduction in subcutaneous fat of aP2-Ucp C57BL/6J mice was observed at 3 mo of age. When the transgene was expressed in Avy genetically obese mice reductions in total body weight and subcutaneous fat stores were observed. Female transgenic Avy mice at 13 mo of age weighed 35 grams, a weight indistinguishable from nontransgenic C57BL/6J mice. Gonadal fat showed an increase in a novel adipocyte derivative that did not accumulate lipids and that constituted approximately 80% of the mass of the tissue in Avy transgenic. A major effect of aP2-Ucp in brown fat was to reduce endogenous gene expression by as much as 95%. The results suggest that UCP synthesized from the aP2 gene promoter is thermogenically active and capable of reducing fat stores.
Inadequate diagnosis and therapy of arterial hypertension as causes of left ventricular hypertrophy in uremic dialysis patients
Authors: Giuseppe Cannella, Ernesto Paoletti, Giambattista Ravera, Paolo Cassottana, Paolo Araghi, Donatella Mulas, Giancarlo Peloso, Roberto Delfino, Piergiorgio Messa
Journal: Kidney International (2000)
Actinomycosis Treated with Aureomycin
Authors: S. A. Seligman
Journal: BMJ (1954)

MEDICAL JOURNALbenefit, as it is often cumbersome, it obscures the field of operation, and it interferes with manipulation.With the use of a Hodge pessary to support the uterus in a normal position from below, through the vagina, damage is not done to the uterine fundus, the field of operation is left clear, and an assistant is hardly necessary.Further, if a pessary of correct size has been used for diagnostic purposes and has relieved the symptoms, it is reasonable to assume that it has maintained the uterus in the optimum position, and that a similar pessary should be in position during the operation.Without its use the uterus may be supported too loosely, in which case the operation may fail in its purpose, or the uterus may be supported too tightly, with the possible substitution of symptoms such as dragging or pain in the iliac fossae and groins.Either of these contingencies is not unknown.Viewed in this light, the Hodge pessary should serve a useful purpose in other operations for correction of retroversion, such as the Gilliam procedure.
Sex Differences in the Electrocardiogram
Authors: ERNST SIMONSON, HENRY BLACKBURN, THOMAS C. PUCHNER, PAULINE EISENBERG, FERNANDA RIBEIRO, MANUEL MEJA
Journal: Circulation (1960)

In 424 men and 142 women, clinically "healthy," ages 40 through 59 years, significant sex differences in electrocardiographic characteristics were found. The differences were minor in the limb-lead amplitudes (P, Q, R, S, T), but QRS and P-R duration was significantly shorter in women. Precordiallead amplitudes (R, S, T) were significantly smaller in women. Present normal standards derived from groups of men are not valid for women.
Detection of Renal Artery Stenosis from Oxygen Saturation and Tension of Renal Vein Blood.
Authors: Chi Kong Liu
Journal: Annals of Internal Medicine (1965)

s1 November 1965Detection of Renal Artery Stenosis from Oxygen Saturation and Tension of Renal Vein Blood.Chi Kong Liu, M.D., Walter P. Martin, M.D., F.A.C.P., Abraham T. K. Cockett, M.D., Truman Long, M.D.Chi Kong Liu, M.D.Search for more papers by this author, Walter P. Martin, M.D., F.A.C.P.Search for more papers by this author, Abraham T. K. Cockett, M.D.Search for more papers by this author, Truman Long, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-63-5-920_3 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe detection of unilateral renal artery stenosis, a potentially curable lesion, is of utmost importance. The use of excretory urography, radiorenography, split renal function tests, and aortography is frequently unsatisfactory. Modification of the above procedures and new techniques are constantly being sought. The reduction of oxygen saturation and tension of the renal vein blood may be of value in identifying the ischemic kidney with an obstructive lesion.Renal vein blood was collected anaerobically by renal vein catheterization or direct puncture. Oxygen saturation was analyzed by the Van Slyke method and tension by the Astrup Po2meter or calculated from the... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Los Angeles, California PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 November 1965Volume 63, Issue 5Page: 920-921KeywordsBloodCatheterizationKidneysLesionsOxygenPartial pressure of oxygenPyelographyRenal arteriesStenosisVeins Issue Published: 1 November 1965 PDF DownloadLoading ...
Biliary symptoms, gallbladder motility, and cholecystectomy
Authors: Antonio Colecchia, Davide Festi
Journal: Hepatology (2006)

We read with great interest the paper by Venneman et al.1 regarding the effect of Ursodeoxycholic acid (UDCA) on symptoms in patients with symptomatic gallstone disease (GS) awaiting elective cholecystectomy. The authors, performing a randomized, double-blind, placebo-controlled trial on the effects of UDCA in 177 symptomatic GS patients scheduled for cholecystectomy, did not find any differences in symptom outcome after 3 months between the UDCA group and the placebo group. The authors concluded that early cholecystectomy is warranted in symptomatic GS. The study protocol included gallbladder motility measurement and the determination as to whether baseline gallbladder motility could affect clinical outcome; no protective effect of impaired gallbladder emptying on biliary symptoms was documented. In fact, the likelihood of remaining colic-free was comparable in strong and weak contractors (31% vs. 33%, respectively). It is well known2, 3 that the choice of the most appropriate therapeutic strategy represents the crucial point in clinical decision-making for gallstone disease and in this sense, the paper by Venneman et al.1 represents an authoritative and important contribution. However, we believe that the indications for cholecystectomy need to be clearly defined, in order to reduce the frequency of inappropriate surgical interventions, as has recently been the case after the introduction and widespread diffusion of laparoscopic cholecystectomy.4 We agree that cholecystectomy represents the gold standard for strongly symptomatic GS, but not in all cases. In fact, available epidemiological studies have clearly documented that at least 35% of symptomatic GS patients do not experience further biliary pain,3 even if, up to now, no definitive predictive factor for biliary pain persistence/recurrence in symptomatic GS has been clearly identified.5 Recently, we performed a prospective study6 evaluating the prognostic meaning of different characteristics of GS, including gallbladder motility, and we documented that gallbladder motility behavior during the follow-up represents an effective predictive factor for symptom persistence/disappearence; in fact, symptomatic patients which progressively reduced gallbladder emptying had no more symptoms while those who did not change their gallbladder motility remained symptomatic. Consequently, periodic evaluation of gallbladder motility could represent a safe and reliable predictive tool in the follow-up of GS, being able to identify patients suitable for early surgery (highly symptomatic GS with persistence of efficient gallbladder motility) from those where a "wait and see" policy may be adopted (symptomatic GS with progressively deficient gallbladder motility). Antonio Colecchia M.D.*, Davide Festi M.D.*, * Department of Internal Medicine and Gastroenterology, University of Bologna, Bologna, Italy.
Cost-Benefit Ratio of Pretransplant Bilateral Nephrectomy
Authors: William M. Bennett
Journal: JAMA (1976)

The posttransplant courses of 27 chronic dialysis patients with 29 grafts who had undergone pretransplant bilateral nephrectomy were compared to those of 49 patients with 55 transplant who had no pretransplant surgery during the same time period. The latter had better survival and fewer rejection episodes (P less than .05). The six patients who died of bacterial sepsis after transplantation all had pretransplant surgery. The frequency of post transplant hypertension was similar in both groups. Apparently, pretransplant bilateral nephrectomy offers no advantage to the patient awaiting an allograft.
Safety of high dose dipyridamole echocardiography test: A multicenter study
Authors: Salvatore Pirelli, Leonardo Bolognese, Gian Paolo Chiriatti, Francesco Faletra, Gabrieila De Pieri, Fabio Lattanzi, Lauro Papi, Daniele Bernardi, Gianni Sarasso, Riccardo Bonelli, Eugenio Picano
Journal: Journal of the American College of Cardiology (1990)
Diagnostic Procedures in Pediatric Ophthalmology
Authors: Albert C. Snell
Journal: JAMA (1964)

The concept that the eye examination of a child requires a 325-page descriptive syllabus may give pause to the reader. Nonetheless, most of the sections of the volume edited by Apt are commendably concise, and are indeed limited to describing diagnostic procedures, with something about the findings inevitably (and usually fortunately) creeping in. A few of the chapters, such as those on uveitis, biomicroscopy, and electromyography, which are evidently included for the sake of completeness, deal with material which cannot be regarded as peculiar to patients of pediatric age. Perhaps this collection's greatest importance is its repetition of the fact that despite the difficulties involved, diagnostic methods should, can, and must be pursued knowledgeably and persistently in children. In the book edited by Holt, the preface and the content fail to make clear what it aims to accomplish. For the most part, the material seems to be directed to the
PD10-04: Exploration of the Relationship between Loss of PTEN and BRCA1 Expression in Triple Negative Breast Carcinoma.
Authors: N Jones, V Velasco, M Reault, V Dapremont, B Gastaldello, A Rouault, F Bonnet, M Debled, C Tunon de Lara, M Longy, G MacGrogan, N Sevenet
Journal: Cancer Research (2011)

Abstract Based on the mechanism of action of PARP inhibitors, BRCAness breast and ovarian cancers could be defined as the optimal group of tumours to target with such drugs. As the BRCAness phenotype is not fully defined at present, a surrogate phenotype of triple negative breast cancer (TNBC) has been proposed. Results of recent clinical trials involving PARP inhibitors in the context of TNBC do not demonstrate a significant improvement in overall survival or progression free survival, partly due to the inaccurate selection of certain tumours. Data from cell culture studies suggests that loss of PTEN expression could be a marker of PARP inhibitor sensitivity. Materials and Methods: A retrospective study of 160 TNBC resected at Institut Bergonie between 1989 and 2010 was undertaken. Inclusion criteria were: ER &amp; PR immunohistochemcial (IHC) negativity (&amp;lt;10% tumour cells positive), non-amplification of HER2 (IHC score 0, 1, or 2 with negative FISH analysis) and an invasive ductal carcinoma resected before chemotherapy. For some familial cases, germline BRCA1 mutation screening had been performed in a diagnostic setting and was accompanied by genetic counselling. PTEN IHC, point mutation and gross rearrangement screening, along with BRCA1 expression and promoter methylation analysis (through real-time PCR and bisulfite treatment, respectively) and 53BP1 IHC were undertaken on this series of TNBC. Results: Twenty percent of sporadic and familial TNBC demonstrated reduced BRCA1 expression with a greater than 7 fold reduction in expression. Almost half of tumours demonstrated a complete loss of PTEN expression as assessed by IHC, with a deleterious PTEN point mutation identified in 5% of cases. Although a slight correlation is observed between the complete loss of PTEN and a reduction in BRCA1 expression, a complete overlap of these two alterations was not observed; tumours with reduced BRCA1 expression do not always demonstrate complete negativity on PTEN IHC and certain tumours displaying complete negativity on PTEN IHC do not show a reduction in BRCA1 expression. Full immunohistochemical characterization of the tumour series (ER, PR, HER2, AR, CK5/6 &amp; EGFR) together with the results of PTEN, BRCA1 and 53BP1 analyses will be presented. Conclusion These results suggest that at present, loss of PTEN expression is not a suitable surrogate marker for tumours with reduced BRCA1 expression. This should be borne in mind for ancillary studies of clinical trials involving PARP inhibitors in the treatment of breast tumours and further investigation is warranted. Citation Information: Cancer Res 2011;71(24 Suppl):Abstract nr PD10-04.
Comparison of thoracic kyphosis in two groups of elite Greco-Roman and freestyle wrestlers and a group of non-athletic participants
Authors: R Rajabi, P Doherty, M Goodarzi, R Hemayattalab
Journal: British Journal of Sports Medicine (2007)

Background: Freestyle and Greco-Roman are two types of wrestling that place the spine of athletes in different positions. Theoretically, it can be argued that this can lead to adverse effects on the spine and might be an important factor associated with changes in the degree of kyphosis. Objectives: The aim of this study was to investigate whether the extent of thoracic kyphosis differs in two groups of elite wrestlers and a group of non-athletic participants. Methods: Sixty elite Iranian male wrestlers including 30 freestyle (mean (SD) age 23.5 (2.8) years, height 176 (7.1) cm and weight 77.8 (16.1) kg) and 30 Greco-Roman (age 23.9 (2.9) years, height 176 (4) cm and weight 80.1 (11.1) kg) wrestlers and 30 male non-athletes (age 23.3 (2.1) years, height 175 (8) cm and weight 75.2 (6.7) kg) were recruited. All wrestlers competed at international level with the Iranian national team or Iranian student national team. Each selected wrestler had to meet a minimum criterion of 5 years' wrestling. The degree of kyphosis was measured using a modified electrogoniometer. Results: Mean (SD) kyphosis was 30° (3.8), 24.3° (3.7) and 27.4° (3.2) for the freestyle, Greco-Roman style and non-athlete groups, respectively. A significant difference was found in mean kyphosis between all groups (p&lt;0.05) with freestyle being the highest and Greco-Roman the lowest. Conclusions: The degree of kyphosis was highest in freestyle wrestling, followed by non-athletes and then Greco-Roman wrestlers. The extent of kyphosis was not influenced by years of training or age of starting wrestling.
Chiropractic treatment is of limited benefit
Authors: S. Gottlieb
Journal: BMJ (1998)

Challenging the main reason that people decide to go to chiropractors, new research shows that spinal manipulations ease back pain no better than specialised physiotherapy and only slightly better than doing nothing at all.

The findings of the study, led by researchers from the University of Washington, are contrary to the growing acceptance of chiropractic spinal manipulation as a treatment for acute lower back pain. In recent years, federal health officials in the United States have endorsed such treatment, and many US insurance companies now pay for it.

The research tracked 321 patients diagnosed with back pain …
Remarks on Prognosis in Exophthalmic Goitre
Authors: R. T. Williamson
Journal: BMJ (1896)

Mortality..0Ozs. Drs.Grs.Suprapubic lithotomy 4 27 O. 5 5 0 34 2, or 50 per cent.Perineal lithotomy ... 14 424 2 5 23 30 4, or 28' Litholapaxy ... 31 52 2 5 2 10_ 3, or 91The average age of the litholapaxy cases was 52 years, ten years greater than that of the perineal lithotomy cases, and double that of the suprapubic cases.The average weight of stone in the suprapubic cases was, however, twice that of the other two varieties of operation; but the period under treat- ment after operation in the litholapaxy cases was only ten days, as compared with thirty and thirty-four days respec- tively in the lithotomy cases.Finally, the mortality, which in the suprapubic operation was 5o per cent.and in the peri- neal 28 per cent., was in the litholapaxy cases reduced to less than Io per cent.Now I am aware, of course, that 4 cases of suprapubic oper- ation do not constitute a sufficiently large number from which to draw any safe or trustworthy conclusion.But a glance at
Pulsed-dye laser versus conventional therapy in the treatment of warts: A prospective randomized trial
Authors: Kristi J. Robson, Nancy M. Cunningham, Kolleen L. Kruzan, Dipa S. Patel, Clarence D. Kreiter, Michael J. O’Donnell, Christopher J. Arpey
Journal: Journal of the American Academy of Dermatology (2000)