tbuckley/cabot-search huggingface dataset:
A Rhinovirus Outbreak among Residents of a Long-Term Care Facility
Authors: Tina G. Wald
Journal: Annals of Internal Medicine (1995)

Objective: To describe the epidemiology of and clinical findings associated with a rhinovirus outbreak that occurred among institutionalized elderly persons. Design: Retrospective review of medical records and nursing surveillance reports. Setting: A 685-bed, long-term care facility for veterans and their spouses. Patients: 33 persons from whom rhinovirus was cultured. Measurements: Throat and nasopharyngeal virus culture; review of medical records to determine underlying diseases, signs and symptoms of respiratory illness, illness duration, and interventions during illness; and review of nursing surveillance reports to determine room locations of ill persons. Results: Between 14 August and 2 September 1993, the number of respiratory illnesses increased. Throat and nasopharyngeal virus cultures were taken from 67 ill residents; 33 cultures yielded rhinovirus, and no other respiratory virus was isolated. Geographic clustering of persons infected with rhinovirus was observed. Of those persons with rhinovirus infections, 100% had upper respiratory symptoms, 34% had gastrointestinal symptoms, 71% had systemic symptoms, 66% had lower respiratory symptoms (including productive cough), and 52% had new abnormalities on lung auscultation. The 17 persons with rhinovirus infection who had chronic obstructive pulmonary disease had more severe illnesses: Five (29%) required glucocorticoid or bronchodilator therapy for illness-associated bronchospasm; 2 required transfer out of the facility; 1 developed a radiographically documented infiltrate; and 1 died of respiratory failure. Conclusions: Rhinovirus may cause epidemic, clinically important respiratory illness in nursing home residents. A large proportion of residents may become ill, and infection may be severe in persons with underlying lung disease.
GRAFT-VERSUS-HOST REACTION COMPLICATING HL-A MATCHED BONE-MARROW TRANSPLANTATION
Authors: RobertG Graw, GeoffreyP Herzig, G.Nicholas Rogentine, RonaldA Yankee, BrigidG Leventhal, Jacqueline Whang-Peng, RogerH Halterman, Gerhard Krüger, Costan Berard, EdwardS Henderson
Journal: The Lancet (1970)
An unusual form of primary systemic amyloidosis: amyloid elastosis: report of a case treated by haematopoietic cell transplantation
Authors: G. Vecchietti, I. Masouye, D. Salomon, C. Dozier, J-H. Saurat, C. Helg, L. Borradori
Journal: British Journal of Dermatology (2003)

Journal Article An unusual form of primary systemic amyloidosis: amyloid elastosis: report of a case treated by haematopoietic cell transplantation Get access G. Vecchietti, G. Vecchietti Departments of Dermatology Search for other works by this author on: Oxford Academic Google Scholar I. Masouyé, I. Masouyé Departments of Dermatology Search for other works by this author on: Oxford Academic Google Scholar D. Salomon, D. Salomon Departments of Dermatology Search for other works by this author on: Oxford Academic Google Scholar C. Dozier, C. Dozier Neurology and Search for other works by this author on: Oxford Academic Google Scholar J‐H. Saurat, J‐H. Saurat Departments of Dermatology Search for other works by this author on: Oxford Academic Google Scholar C. Helg, C. Helg Oncology, University Hospital, Rue Micheli‐du‐Crest 24, CH‐1211 Geneva 14, Switzerland Search for other works by this author on: Oxford Academic Google Scholar L. Borradori L. Borradori Departments of Dermatology Luca Borradori. E‐mail: Luca.Borradori@hcuge.ch Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 148, Issue 1, 1 January 2003, Pages 154–159, https://doi.org/10.1046/j.1365-2133.2003.05036.x Published: 01 January 2003 Article history Accepted: 10 June 2002 Published: 01 January 2003
Clonality and genomic heterogeneity in HCC and putative precursor nodular lesions
Authors: Alberto Quaglia, Cristoph Laurent, Salvatore Girlando, Jitendra Saini, Paolo Dalla Palma, Romano Colombari, Paulette Bioulac-Sage, Charles Balabaud, Brian Davidson, Roberto Togni, Amar Paul Dhillon
Journal: Journal of Hepatology (2002)
International Trends of Therapy and Research in Psychosomatic Medicine
Authors: H. Warnes, J. Blustein
Journal: Psychotherapy and Psychosomatics (1987)

Against the background of the holistic concept of illness trends of psychosomatic therapy and research are identified in major countries. Different countries tend to concentrate on different aspects of research or praxis based largely on their compatibility with cultural or social assumptions of illness. The psychotherapies, behavioral medicine, social therapies and biological approaches are underscored in a given country and even within the same country competing therapies strive for hegemony. Problems and limitations of the reductionistic versus the holistic approaches in psychosomatic research are highlighted.
Acquired pure megakaryocytic aplasia report of two cases with long-term responses to antithymocyte globulin and cyclosporine
Authors: Joseph W. Leach, Khader K. Hussein, James N. George
Journal: American Journal of Hematology (1999)

Acquired pure megakaryocytic aplasia is a rare disorder defined by severe thrombocytopenia with no other hematologic abnormalities and absent, or severely decreased marrow megakaryocytes. The etiology may be immune suppression of megakaryocyte development. Two patients are described who both responded rapidly to a combination of antithymocyte globulin and cyclosporine and who remain in remission 13–20 months after discontinuation of cyclosporine. This regimen is well described for treatment of aplastic anemia and may also be effective for acquired pure megakaryocytic aplasia. Am. J. Hematol. 62:115–117, 1999. © 1999 Wiley-Liss, Inc.
PAin SoluTions In the Emergency Setting (PASTIES)--patient controlled analgesia versus routine care in emergency department patients with non-traumatic abdominal pain: randomised trial
Authors: J. E. Smith, M. Rockett, S. Creanor, R. Squire, C. Hayward, P. Ewings, A. Barton, C. Pritchard, V. Eyre, L. Cocking, J. Benger
Journal: BMJ (2015)

<b>Objective</b> To determine whether patient controlled analgesia (PCA) is better than routine care in providing effective analgesia for patients presenting to emergency departments with moderate to severe non-traumatic abdominal pain. <b>Design</b> Pragmatic, multicentre, parallel group, randomised controlled trial <b>Setting</b> Five English hospitals. <b>Participants</b> 200 adults (66% (n=130) female), aged 18 to 75 years, who presented to the emergency department requiring intravenous opioid analgesia for the treatment of moderate to severe non-traumatic abdominal pain and were expected to be admitted to hospital for at least 12 hours. <b>Interventions</b> Patient controlled analgesia or nurse titrated analgesia (treatment as usual). <b>Main outcome measures</b> The primary outcome was total pain experienced over the 12 hour study period, derived by standardised area under the curve (scaled from 0 to 100) of each participant's hourly pain scores, captured using a visual analogue scale. Pre-specified secondary outcomes included total morphine use, percentage of study period in moderate or severe pain, percentage of study period asleep, length of hospital stay, and satisfaction with pain management. <b>Results</b> 196 participants were included in the primary analyses (99 allocated to PCA and 97 to treatment as usual). Mean total pain experienced was 35.3 (SD 25.8) in the PCA group compared with 47.3 (24.7) in the treatment as usual group. The adjusted between group difference was 6.3 (95% confidence interval 0.7 to 11.9). Participants in the PCA group received significantly more morphine (mean 36.1 (SD 22.4) <i>v</i> 23.6 (13.1) mg; mean difference 12.3 (95% confidence interval 7.2 to 17.4) mg), spent less of the study period in moderate or severe pain (32.6% <i>v</i> 46.9%; mean difference 14.5% (5.6% to 23.5%)), and were more likely to be perfectly or very satisfied with the management of their pain (83% (73/88) <i>v</i> 66% (57/87); adjusted odds ratio 2.56 (1.25 to 5.23)) in comparison with participants in the treatment as usual group. <b>Conclusions</b> Significant reductions in pain can be achieved by PCA compared with treatment as usual in patients presenting to the emergency department with non-traumatic abdominal pain. <b>Trial registration</b> European Clinical Trials Database EudraCT2011-000194-31; Current Controlled Trials ISRCTN25343280.
Vulvitis circumscripta plasmacellularis (Zoon's vulvitis) associated with autoimmune polyglandular endocrine failure
Authors: T.G. SALOPEK, K. SIMINOSKI
Journal: British Journal of Dermatology (1996)

Vulvitis circumscripta plasmacellularis (Zoon's vulvitis) is a distinct clinicopathological entity which presents as a shiny, atrophic. crylhematous plaque of the vulva. It is an idiopathic condition with characteristic clinical and histok)glcal lindings thai generally occur in isolation of otber medical disorders. We report a id‐year‐old woman with ulvitis circumscripta piasmacellularis associated with polyglandular endocrine failure and circulating iiutoimmune antibodies. The association between Zoon's vulvitis and these autoimmune conditions raises the possibility tbat Zoon's vulvitis may be an autoimmune disorder.
Byssinosis and Chronic Bronchitis Among Cotton Textile Workers
Authors: JAMES A. MERCHANT
Journal: Annals of Internal Medicine (1972)

A survey of a modern cotton-synthetic blend mill was conducted to determine the prevalence and distribution of byssinosis, the effects of smoking, aging, and cotton-dust exposure on the frequency and severity of byssinosis, chronic bronchitis, and dyspnea (defined by index ratings), and whether total-dust samples would indicate byssinosis risk. Twenty percent of those working in preparation areas, 2% of those in yarn processing areas, and 6% of all employees were diagnosed as byssinotic. Among men, the byssinosis index increased with smoking and the bronchitis index increased with smoking plus dust exposure. Byssinotic workers were found to have more chronic bronchitis and dyspnea than matched control workers. It is concluded that byssinosis and chronic bronchitis are both influenced by cotton-dust exposure and cigarette smoking. Total-dust samples, in this plant, gave no indication of byssinosis risk.
Bevacizumab-Associated Osteonecrosis of the Wrist and Knee in Three Pediatric Patients With Recurrent CNS Tumors
Authors: Jason Fangusaro, Sridharan Gururangan, Regina I. Jakacki, Sue C. Kaste, Stewart Goldman, Ian F. Pollack, James M. Boyett, Larry E. Kun
Journal: Journal of Clinical Oncology (2012)
Characterization of a Hyperdynamic Murine Model of Resuscitated Sepsis Using Echocardiography
Authors: STEVEN M. HOLLENBERG, ANDREW DUMASIUS, CORDUS EASINGTON, SUSAN A. COLILLA, ALEX NEUMANN, JOSEPH E. PARRILLO
Journal: American Journal of Respiratory and Critical Care Medicine (2001)

A small animal model of sepsis that reproduces the vasodilation, hypotension, increased cardiac output, and response to treatment seen in patients with septic shock would be useful for studies of pathophysiology and treatment, but no current models replicate all of these features. Mice were made septic by cecal ligation and puncture and resuscitated with fluids and antibiotics every 6 h. Blood pressure was measured in anesthetized mice with manometric catheters, and echocardiography was performed in these animals every 6 h. Survival in treated septic mice was improved compared with untreated mice (44% versus 0%, p < 0.01). In control mice, heart rate (HR, 420 ± 31 beats/min), mean arterial pressure (Pa, 100 ± 8 mm Hg), stroke volume (SV, 26 ± 4 μ l), and cardiac output (12.5 ± 6.6 ml/min) were unchanged over 48 h. In septic mice Pa was significantly decreased (102 ± 14 to 65 ± 19 mm Hg, p < 0.02), starting at 12 h. HR and cardiac output increased significantly (HR, 407 ± 70 to 524 ± 76 beats/min, cardiac output, 11.6 ± 2.0 to 17.1 ± 1.5 ml/min, p < 0.01). SV (24 ± 5 μ l) remained constant. This fluid-resuscitated, antibiotic-treated model replicates the mortality, hypotension, and hyperdynamic state seen in clinical sepsis. Precise determination of serial hemodynamics in this model may be useful to elucidate pathophysiologic mechanisms and to evaluate new therapies for septic shock.Keywords: sepsis; hemodynamics; echocardiography; fluid resuscitation; animal model
The Safety of Adult Male Circumcision in HIV-Infected and Uninfected Men in Rakai, Uganda
Authors: Godfrey Kigozi, Ronald H Gray, Maria J Wawer, David Serwadda, Frederick Makumbi, Stephen Watya, Fred Nalugoda, Noah Kiwanuka, Lawrence H Moulton, Michael Z Chen, Nelson K Sewankambo, Fred Wabwire-Mangen, Melanie C Bacon, Renee Ridzon, Pius Opendi, Victor Sempijja, Absolom Settuba, Denis Buwembo, Valerian Kiggundu, Margaret Anyokorit, James Nkale, Nehemia Kighoma, Blake Charvat
Journal: PLoS Medicine (2008)

The objective of the study was to compare rates of adverse events (AEs) related to male circumcision (MC) in HIV-positive and HIV-negative men in order to provide guidance for MC programs that may provide services to HIV-infected and uninfected men.A total of 2,326 HIV-negative and 420 HIV-positive men (World Health Organization [WHO] stage I or II and CD4 counts > 350 cells/mm3) were circumcised in two separate but procedurally identical trials of MC for HIV and/or sexually transmitted infection prevention in rural Rakai, Uganda. Participants were followed at 1-2 d and 5-9 d, and at 4-6 wk, to assess surgery-related AEs, wound healing, and resumption of intercourse. AE risks and wound healing were compared in HIV-positive and HIV-negative men. Adjusted odds ratios (AdjORs) were estimated by multiple logistic regression, adjusting for baseline characteristics and postoperative resumption of sex. At enrollment, HIV-positive men were older, more likely to be married, reported more sexual partners, less condom use, and higher rates of sexually transmitted disease symptoms than HIV-negative men. Risks of moderate or severe AEs were 3.1/100 and 3.5/100 in HIV-positive and HIV-negative participants, respectively (AdjOR 0.91, 95% confidence interval [CI] 0.47-1.74). Infections were the most common AEs (2.6/100 in HIV-positive versus 3.0/100 in HIV-negative men). Risks of other complications were similar in the two groups. The proportion with completed healing by 6 wk postsurgery was 92.7% in HIV-positive men and 95.8% in HIV-negative men (p = 0.007). AEs were more common in men who resumed intercourse before wound healing compared to those who waited (AdjOR 1.56, 95% CI 1.05-2.33).Overall, the safety of MC was comparable in asymptomatic HIV-positive and HIV-negative men, although healing was somewhat slower among the HIV infected. All men should be strongly counseled to refrain from intercourse until full wound healing is achieved.http://www.ClinicalTrials.gov; for HIV-negative men #NCT00425984 and for HIV-positive men, #NCT000124878.
THE EFFECT OF NIGHTTIME BLOOD PRESSURE VARIABILITY ON LEFT VENTRICULAR HYPERTROPHY AND CAROTID INTIMA MEDIA THICKNESS IN PATIENTS WITH NSTEMI
Authors: Shunsuke Kataoka, Kozo Okada, Masaomi Gohbara, Noriaki Iwahashi, Kengo Tsukahara, Yoshio Tahara, Kiyoshi Hibi, Masami Kosuge, Toshiaki Ebina, Satoshi Umemura, Kazuo Kimura
Journal: Journal of the American College of Cardiology (2013)
Demonstration of defective C3-receptor-mediated clearance by the reticuloendothelial system in patients with acquired immunodeficiency syndrome.
Authors: B S Bender, J F Bohnsack, S H Sourlis, M M Frank, T C Quinn
Journal: Journal of Clinical Investigation (1987)

The function of macrophage C3 receptors was assessed in vivo by measuring the clearance of C3-sensitized autologous erythrocytes in seven acquired immunodeficiency syndrome (AIDS) patients, eight healthy homosexual men, eight healthy heterosexual men, and four infected controls. Healthy heterosexual men had an initial clearance of 50.1 +/- 2.0% of the inoculum, with a release of a small portion of these cells (10.9 +/- 1.3%) into the circulation. Healthy homosexual men had a greater initial clearance of 66.0 +/- 4.2% (P less than 0.01) followed by a similar release (14.0 +/- 3.3%). AIDS patients had an initial clearance of 60.6 +/- 7.5% but had a relatively large release of cells (25.6 +/- 3.2%) (P less than 0.005 vs. heterosexuals; P less than 0.05 vs. homosexuals), suggesting a failure of macrophage phagocytosis. Infected controls had an initial clearance of 59.4 +/- 4.9%, with a release of 19.6 +/- 3.8% (P = NS vs. AIDS). These data, in addition to Fc-receptor dysfunction, demonstrate a global reticuloendothelial system dysfunction in AIDS patients. This may contribute to their frequent infections with opportunistic pathogens and inappropriate immune responses against these microorganisms.
Cardiac 7-transmembrane-spanning domain receptor portfolios: diversify, diversify, diversify
Authors: S. B. Liggett
Journal: Journal of Clinical Investigation (2006)

Enhanced signaling in myocytes by the G protein Gq has been implicated in cardiac hypertrophy and the transition to heart failure. α1-Adrenergic receptors (α1-ARs) are members of the 7-transmembrane-spanning domain (7-TM) receptor family and signal via interaction with Gq in the heart. The specific effects of a loss of α1-AR signaling in the heart are explored by O’Connell et al. in this issue of the JCI (see the related article beginning on page 1005). Paradoxically, gene ablation of the α1A and α1B subtypes in mice results in a maladaptive form of reactive cardiac hypertrophy from pressure overload, with a predisposition to heart failure. Thus signaling to the α1-AR (compared with signaling from other receptors such as angiotensin receptors, which also couple to Gq) appears to be specifically required for a normal hypertrophic response. This represents another example of how receptors that share common G proteins have diversified, developing unique signaling programs. These findings may have particular clinical relevance because of the widespread use of α1-AR antagonists in the treatment of hypertension and symptomatic prostate enlargement.
Scrotal Edema: Beyond Omega
Authors: LORENZO D. MASSEY
Journal: Annals of Internal Medicine (1972)

Letters, Comments, and Corrections1 February 1972Scrotal Edema: Beyond OmegaLORENZO D. MASSEY, M.D.LORENZO D. MASSEY, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-76-2-334_2 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: I have noted with interest the report by Dr. Conn, in the June 1971 issue (p. 943-945), on developing scrotal edema in cirrhotic patients with ascites after abdominal paracentesis, as well as the letters, in the September and November issues, on paracentesis with small needles in carefully prepared patients.In July 1971 I had a patient with such scrotal edema with abducted legs after paracentesis of the abdomen for the ascites, which was caused by metastatic carcinoma from a lesion of the descending colon. I concluded that the scrotal swelling, following shortly after the abdominal paracentesis, was...References1. CONN H: Unilateral edema and jaundice following portacaval anastomosis. Ann Intern Med. In press Google Scholar2. MARKSWEIL JF: Conn's sudden labial edema. Ann Intern Med 75:810, 1971 LinkGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Osceola Memorial Hospital Osceola, Ark. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byUnilateral Edema and Jaundice After Portacaval AnastomosisHAROLD O. CONN 1 February 1972Volume 76, Issue 2Page: 334-335KeywordsAscitesColonEdemaInflammationLesions Issue Published: 1 February 1972 PDF downloadLoading ...
Physician Education and Cost Containment
Authors: Stephen B. Soumerai
Journal: JAMA (1985)

<h3>To the Editor.—</h3> The conclusion by Schroeder et al<sup>1</sup>in their recent article that "in the absence of other cost containing incentives, physician education alone is not an effective hospital cost containment strategy" seems overstated on the basis of their negative findings from a single nonrandomized study. In the prescribing area, for example, our recent randomized controlled trial (n=435 physicians) of targeted, one-on-one educational "detailing" resulted in substantial savings and reductions in unnecessary drug use in the Medicaid sector alone.<sup>2</sup>These effects occurred in the absence of either financial incentives or data feedback. We are now completing a formal benefit-cost analysis of these findings, which indicates that with suitable targeting of high-cost physicians, program savings far exceed program costs. Schaffner et al<sup>3</sup>have similarly shown success in improving the precision and cost-effectiveness of physicians' clinical decision making. In a broader context, the review of 247 continuing medical
Case 27-1966
Authors: Lot B. Page, Paul Kimmelstiel
Journal: New England Journal of Medicine (1966)

Presentation of Case First admission. A twenty-seven-year-old woman was admitted to the hospital because of hypertension.At the age of seven years she had received x-irradiation to the thymus gland. Fourteen years before entry, at the time of an appendectomy, the blood pressure was 115 systolic, 70 diastolic, and a specimen of urine gave a trace test for protein but was otherwise normal. Two years later the menarche occurred and was followed by severe metrorrhagia that did not respond to hormonal therapy. Six years before admission she entered the hospital because of gallstones. The blood pressure was 170 systolic, . . .