tbuckley/cabot-search huggingface dataset:
When Shingles Wanes But Pain Does Not
Authors: Tracy Hampton
Journal: JAMA (2005)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Abstract 2986: Did Early Hazard of PCI Offset Late Benefit in the Occluded Artery Trial (OAT)?
Authors: Christopher E Buller, James M Rankin, Jean Renkin, Ronald G Carere, Vladimir Dzavik, Witold Ruzyllo, Sandra A Forman, Pawel E Buszman, G. B. John Mancini, Pedro F Abreu, Gervasio A Lamas, Judith S Hochman
Journal: Circulation (2007)

Background: The Occluded Artery Trial (OAT) showed no reduction in death, MI or class IV CHF with routine PCI in occluded infarct-related coronary arteries in stable patients identified up to 28 days post MI. PCI of non-acute coronary occlusions can be complex and hazardous. We report the magnitude and nature of PCI-related early hazard in OAT and its contribution to overall trial results. Methods: All 1101 PCI and 1100 medical therapy (MED) assigned patients were examined by intention-to-treat. Pre-specified events (death, MI, class III or IV HF) and procedural complications during the first 48 hours after OAT enrollment (including at least 24 hours post protocol-driven PCI) were analyzed, and the OAT primary composite outcome (death, adjudicated MI, or new class IV HF) was examined at 5 and 30 days, and 60 months. Results: Events or complications within 48 hours of enrollment occurred in 55 PCI patients (5.0%) versus 29 MED patients (2.6%) (p=0.01). PCI patients experienced more class III or IV HF events (5 vs. 2), coronary perforation (4 vs. 1), ventricular arrhythmias (6 vs. 2), CNS complications (3 vs. 2), major hemorrhage (8 vs. 1), and vascular complications (5 vs. 1). Cardiac rupture occurred in 4 patients; 2 in each arm. Events/complications were deemed PCI-related by sites in 35 of 55 patients, and by central review in 30 of 55. Attribution by sites and central review were generally concordant and indicate that the observed events excess was causally related to PCI procedures. Conclusion: While there was no excess mortality in the PCI-treated group, events and complications during the first 48 hours were significantly more common in OAT patients assigned PCI than in those assigned MED. This early procedural hazard, however, was small in magnitude and was not followed by convergence of event rates through 60 months. We conclude the absence of net benefit for routine PCI in OAT cannot be explained by early hazard offsetting late benefit. Primary Outcome Life Table Event Rates: 48 hrs, 5 and 30 days, and 60 months
Abstract 420: Stearoyl-coa Desaturase-1 Protects Against Saturated Fatty Acids-Induced Osteogenic Differentiation and Apoptosis of Vascular Smooth Muscle Cells
Authors: Hiroki Matsui, Tomoyuki Yokoyama, Kenichi Sekiguchi, Yousuke Gotoh, Tatsuya Iso, Masashi Arai, Masahiko Kurabayashi
Journal: Circulation (2008)
Abstract 17730: Aberrant Endothelial FGF Signaling Due to Disruption of MicroRNAs 424/503 in Pulmonary Arterial Hypertension
Authors: Jongmin Kim, Yoko Kojima, Yujung Kang, Micheala Aldred, Danielle McLean, Suzy Comhair, Serpil Erzurum, Hyung J Chun
Journal: Circulation (2011)

Pulmonary arterial hypertension (PAH) is a disease characterized by the vascular remodeling of the pulmonary arterioles, including formation of plexiform and concentric lesions comprised of proliferative endothelial cells. We recently found that disruption of the G protein-coupled receptor signaling axis comprised of the ligand apelin and the receptor APJ leads to significant worsening of hypoxia induced pulmonary hypertension (PH) in mice, and found that the pathway is also perturbed in clinical PAH. To characterize novel downstream endothelial targets which may be utilized by apelin-APJ signaling to protect against the vascular remodeling processes in PAH, we carried out a microRNA (miRNA) array analysis of pulmonary artery endothelial cells (PAECs) subjected to knockdown of apelin, APJ, or both. We identified two miRNAs (miR-424 and miR-503) that are highly expressed in PAECs, but are significantly downregulated in the context of apelin/APJ knockdown. Remarkably, we found marked decrease in levels of miR-424 and miR-503 in the experimental monocrotaline (MCT) rat model of PH, as well as in PAECs isolated from a subset of patients with clinically diagnosed PAH. Our in vitro functional studies demonstrated that both miR-424 and miR-503 exert anti-proliferative, anti-angiogenic effects, via a mechanism that targets two key components of the fibroblast growth factor (FGF) signaling pathway, namely FGF2 and FGFR1. Consequently, we found marked increase in protein levels of FGF2 and FGFR1 in PAECs from PAH patients, as well as lungs of rats with MCT induced PH. Lastly, we found that restoration of miR-424/503 expression in the MCT induced model of PH by intranasal lentiviral delivery can significantly decrease FGF2 and FGFR1 expression and ameliorate the severity of the disease as demonstrated by decreased right ventricular systolic pressure (38 vs. 24.3 mmHg, p&lt;0.001, n=5-8/group) and RV/LV+septum weight ratio (0.52 vs. 0.43, p&lt;0.05). We conclude that miR-424/503 play a critical role in maintaining pulmonary vascular homeostasis, and that disruption of their expression serves a critical contribution to the aberrant endothelial proliferation that is a hallmark of PAH.
Abstract 9011: Randomized Trial of Fondaparinux versus Heparin to Prevent Graft Failure After Coronary Artery Bypass Grafting: The Fonda CABG Pilot Study
Authors: Jack C Sun, Andre Lamy, Kevin H Teoh, Tej Sheth, David Landry, Hyejung Jung, Salim Yusuf, John W Eikelboom
Journal: Circulation (2010)
Abstract P98: Impact of Hemodynamic State in Mild Hypothermia Therapy after Cardiac Arrest
Authors: Shinichi Shirai, Kenji Ando, Koyu Sakai, Yoshimitsu Soga, Katsuhiro Kondo, Masahiko Goya, Masashi Iwabuchi, Hiroyoshi Yokoi, Hitoshi Yasumoto, Hideyuki Nosaka, Masakiyo Nobuyoshi
Journal: Circulation (2008)
Abstract 4788: Long-Term Survival of the Very Elderly Undergoing Aortic Valve Surgery
Authors: Donald S Likosky, Lawrence J Dacey, Yvon R Baribeau, Bruce J Leavitt, Anthony W DiScipio, Felix Hernandez, Richard P Cochran, Reed D Quinn, Robert E Helm, David C Charlesworth, Robert A Clough, David J Malenka, Elaine M Olmstead, Cathy S Ross, Gerald T O’Connor
Journal: Circulation (2008)

Increasing numbers of the very elderly are undergoing aortic valve procedures. We describe the short and long-term survivorship for this cohort. We conducted a cohort study of 8,796 consecutive patients undergoing aortic valve surgery without (48.0%; AVR) or with (52.0%) concomitant coronary artery bypass graft (CABG) surgery (AVR-CABG) between November 10, 1987 through June 30, 2006. Patient records were linked to the Social Security Administration’s Death Master File. Survivorship was stratified by age strata and concomitant CABG surgery. During 44,,435 person years of follow-up, there were 3,236 deaths. Among AVR, there were 3,939 patients &lt;80 yrs, 463 patients 80 – 84 yrs, and 174 patients 85 + yrs (29 patients ≥90 yrs). Among AVR-CABG patients, there were 3,312 patients &lt;80 yrs, 656 patients 80 – 84 yrs, and 252 patients 85+ yrs (22 patients ≥90 yrs). Increasing age among patients undergoing isolated AVR was associated with female gender, more vascular disease and congestive heart failure, procedural urgency, while less diabetes. Increasing age among AVR-CABG patients was associated with female gender, left main stenosis, procedural urgency, more congestive heart failure, while less diabetes and lower ejection fraction. Median survivorship was better for patients undergoing AVR: 11.8 yrs (&lt;80 yrs), 6.7 yrs (80 – 84 yrs), 6.1 yrs (85+yrs) than patients undergoing AVR-CABG: 9.3 yrs (&lt;80 yrs), 6.3 yrs (80 – 84 yrs), and 5.6 yrs (85+ yrs), though this effect diminished with age. Octogenarians undergoing aortic valve surgery have a surprisingly favorable survivorship, with more than half of these patients still alive 6 years after their procedure. Concomitant CABG surgery diminishes this survivorship only slightly. Percent of Patients Surviving by Age Group, Procedure and Time Period
Abstract 13970: Association of Wall Shear Stress with Atherosclerotic Plaque Burden and Composition: A Radiofrequency Intravascular Ultrasound Evaluation in Patients with Coronary Artery Disease
Authors: Parham Eshtehardi, Michael C McDaniel, Jin Suo, Saurabh S Dhawan, Lucas H Timmins, Jose N Binongo, Lucas Golub, Sandeep Krishnan, R Wayne Alexander, W Robert Taylor, Arshed A Quyyumi, Don P Giddens, Habib Samady
Journal: Circulation (2011)

Introduction: Very limited data exist regarding the interplay between coronary wall shear stress (WSS), plaque burden and plaque composition in patients with CAD.Hypothesis: We hypothesized that hi...
Milk Consumption and the Growth of School Children. Report on an Investigation in Lanarkshire Schools.
Authors: G. Leighton, P. L. Mckinlay
Journal: JAMA (1931)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Abstract 16546: Prostaglandin I2 Induced Pulmonary Artery Smooth Muscle Cells Apoptosis via Upregulation of Fas Ligand in Idiopathic Pulmonary Arterial Hypertension
Authors: Satoshi Akagi, Kazufumi Nakamura, Hiromi Matsubara, Aiko Ogawa, Kengo Kusano, Hiroshi Ito
Journal: Circulation (2010)
Abstract 5506: Warfarin Effectiveness and Stroke Rate in Ambulatory Patients With Non-valvular Atrial Fibrillation Managed in Community-based Primary Care Practices
Authors: Edward Ewen, Daniel J Elliott, Teresa A Simon, Shyamkrishnan Ramdas, Joseph Jackson, William S Weintraub
Journal: Circulation (2009)

Background: Despite the known efficacy of warfarin for the prevention of stroke in non-valvular atrial fibrillation (NVAF), its effectiveness in primary care practice is less clear. This study examined the use of warfarin, the time in therapeutic range, and the incidence rate of first-time stroke in NVAF patients in a community-based primary care population. Methods: We performed a retrospective evaluation of patients with NVAF from 1998–2009 in a large health system with a shared electronic medical record. The presence of NVAF, warfarin use, INR values, and stroke events were collected through a review of office and hospital records, laboratory values, and medication use. Exposure was categorized into four categories: no warfarin, warfarin with INR &lt; 2, warfarin with INR 2–3, and warfarin with INR &gt; 3. Person-time in days was computed for each category and incidence rates for stroke by warfarin exposure were computed. Results : A total of 840 NVAF patients qualified; with a mean age of 71 years, 49% female, and 14% African-American. Of these, 511 were exposed to warfarin, of whom 207 (40.5%) had complete INR records available. During 885 person-years of follow-up for these 207 patients, warfarin was continued through only 48.9% (432 person-yrs.). The INR was maintained at or above therapeutic range for 60.3% (260 person-yrs.) of the time for patients on warfarin. There were 18 strokes in the 207 with complete INR values, of which 11 (61%) occurred while off anticoagulation. Effective anticoagulation was associated with lower stroke rates (see table ). Conclusion: In this community-based setting, of the patients with complete INR records, effective warfarin use was associated with a 37.5% reduction in stroke risk; however, in these patients anticoagulation was attempted less than 50% of the time and therapeutic range achieved less than 25% of this time. Our data suggest further inquiry is needed into the reasons for failing to achieve adequate anticoagulation in actual practice. Stroke Rates by Treatment and Effectiveness*
Microvascularized fibular graft for mandibular reconstruction: detection of viability by bone scintigraphy and SPECT.
Authors: ISABEL HERVAS, L. MIGUEL FLORIA, PILAR BELLO, MA CARMEN BAQUERO, ROSA PEREZ, JOSE BAREA, AM IGLESIAS, ANTONIO MATEO
Journal: Clinical Nuclear Medicine (2001)

Bone allografts are often used in reconstructive mandibular surgery, generally after extensive oncologic resection, post-traumatic pseudoarthrosis, or osteomyelitis. Vascularized fibular bone grafts have advantages compared with other bone grafts in the restoration of the contour and function of defective mandibles. Bone scintigraphy is often used to assess bone revascularization, because positive uptake of Tc-99m hydroxy methylene diphosphonate (HDP) reflects patent anastomoses and viability of the grafted bone. Mandibular reconstruction with a free fibular flap was performed in 11 patients. Bone scintigraphy and SPECT were applied in the follow-up of eight patients. The grafts were assessed semi-quantitatively using a six-grade scoring system based on a comparison of tracer uptake in the graft and in the calvarium. Complications were observed in one graft. Planar scintigrams showed a tracer uptake greater than grade 5 in grafts with an uncomplicated course. SPECT was performed in addition to planar imaging in two patients who had greater graft uptake. A lack of tracer uptake was observed in the failed graft. Bone scintigraphy performed within the first week after the mandibular reconstruction is a useful tool to monitor the viability and early complications of microvascularized fibular grafts and plays an important role in the decision-making process during repeated surgical exploration. SPECT is more sensitive than planar imaging for assessing graft viability.
Stem Cell Pressure
Authors: Brian Vastag
Journal: JAMA (2004)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Abstract 21188: Differential Roles of NOX1/NOXO1 and NOX2/p47phox Complexes in Endothelial Responses to Laminar and Oscillatory Shear Stress
Authors: Ling Gao, Hua Cai
Journal: Circulation (2010)

Introduction: Whereas laminar shear stress (LSS) is vasoprotective, oscillatory shear stress (OSS) is atherogenic. Their potentially differential effects on vascular NAD(P)H oxidase (NOX) complexes...
Abstract 5892: Therapy For Device-determined Ventricular Arrhythmias Decrease As Biventricular Pacing Percentage Increases In Heart Failure Patients
Authors: Bruce A Koplan, Andrew J Kaplan, Paul W Jones, Milan Seth, Shelly A Christman
Journal: Circulation (2008)

Introduction: CRT-D improves cardiac function and quality of life, and decreases HF hospitalization and death for many patients. However, impact on therapy delivered for ventricular arrhythmias is less clear. Methods: Device-determined VT and VF episodes with therapy (n = 1835) from CRT-D patients in two trials (CRT RENEWAL &amp; REFLEX; n = 1698) were analyzed in a post hoc fashion. Patients were divided into lifetime biventricular (BiV) pacing percentage quartiles. Zero-inflated Poisson regression models were used to evaluate impact of pacing on VT/VF incidence and frequency, adjusting for baseline covariates including lifetime ATR mode switch percentage. Results: Patient characteristics: 69 ± 11 years, 73% male, 68% CAD. Dividing patients in quartiles resulted in the following pacing breakdown: 0–92% (n = 445), 93–97% (n = 445), 98–99% (n = 482), and 100% (n = 326). There were no differences in gender, NYHA, or history of diabetes, MI, CAD or hypertension among the groups. Patients paced 0–92% and 93–97% had similar VT/VF therapy incidence (24.72% vs. 24.27%) and frequency (17.05% vs. 16.00%). Patients paced 98–99% had lower VT/VF therapy incidence (15.15%) than patients paced ≤ 97% (p &lt; 0.001) but similar frequency after adjusting for incidence. Patients paced 100% had similar VT/VF therapy incidence (13.80%) and frequency (6.45%) to patients paced 98–99%. The figure shows the time to first therapy for VT/VF. Conclusions: For CRT-D patients in this analysis, incidence and frequency of therapy delivered for VT/VF is significantly decreased when lifetime BiV pacing percentage is above 97%.
Care models for discharged psychiatric patients
Authors: S P Sashidharan, M. Smyth, P. Tyrer, P. Harrison-Read, T. Johnson
Journal: BMJ (1998)

Editor—Tyrer et al’s conclusion that aftercare for psychiatric patients with severe mental illness by community teams has a similar outcome to that by hospitals is surprising until one appreciates the rudimentary form of community intervention that they used in the study.1 The two methods of follow up they compared seem to have many similarities, except that the community follow up was provided by a team based outside the hospital. This is not really community treatment—two styles of intervention were compared that were not distinct in terms of the care and treatment given to the patients. This may be why Tyrer et al found no substantial difference in outcome between the two approaches. Tyrer himself has recently described this kind of community treatment as profligate and little short of disastrous.2

Community based care is superior to conventional care in cost benefit terms if the treatment is similar to assertive community treatment.3,4 Tyrer et al, however, analysed a type of community treatment that can hardly be distinguished from conventional hospital based follow up. Their conclusion that community based teams for severely mentally ill patients offer no advantage is misleading unless the type of care offered in the community is a diluted version of approaches that are being implemented elsewhere with considerable clinical benefits.5

Tyrer et al’s observation that the costs of mental health care in the outer London area exceed those in inner London—which has more beds—is not surprising. As there is no comprehensive and integrated system of community care there will inevitably be a continued reliance on hospital beds. When an area does not have enough hospital beds there will be a demand for extracontractual referrals elsewhere, and the costs are bound to rise. This is surely a result of an absence of community care, which contributes to the pressures of escalating costs in relation to inpatient care. The lack of alternatives for crisis situations in both study areas that Tyrer et al describe is evident from the finding that 74% of the community group and 87% of the hospital group required readmission to hospital within 12 months. The need to develop alternative strategies to routine admission—for example, home treatment— is pressing. If there is no integrated community care programme the costs associated with mental health care will increase. An approach without a specialised focus to the management of severe mental illness in the community offers few advantages, a finding that is already well established and even described as dubious practice.3
Abstract 16067: c-Myb Levels Regulate Flk1+ Progenitors and Subsequent Smooth Muscle Differentiation From Mouse Embryonic Stem Cells.
Authors: Masayoshi Ishida, Omar El-Mounayri, Steven Kattman, Hiroshi Sakamoto, Minetaro Ogawa, Gordon Keller, Mansoor Husain
Journal: Circulation (2010)

Background: c-myb encodes the transcription factor c-Myb, which is involved in hematopoiesis (HP) and vascular smooth muscle cell (SMC) proliferation. However, a mechanism for why c-myb knockout (KO) mouse embryonic stem cells (ESC) cannot form contractile SMC in embryoid bodies (EB), but form contracting cardiomyocytes (CM) with greater efficiency than wild-type (WT) ESC, was not known. Flk1 and PDGFRα are surface markers used to identify early progenitors. Here we report on the regulated expression and role of c-Myb during SMC differentiation from specific progenitors. Methods & Results: Western blot revealed high levels of c-Myb on d0-2 of differentiation in WT EB, with rapid and complete loss of c-Myb on d2.5-3, and re-expression on d4−6. Loss of c-Myb on d2.5-3 was not associated with changes in c-myb mRNA, but was completely blocked by the proteosome inhibitor MG132. ESC-derived cardiovascular progenitors induced by Activin-A and BMP4 underwent flow cytometry for Flk1 and PDGFRα. By d3.75, the appea...
Abstract 20778: Inducible Myocardial Ischemia Predicts Future Acute Coronary Syndromes in Healthy Individuals with a Family History of Premature Coronary Artery Disease
Authors: Brian G Kral, Diane M Becker, Dhananjay Vaidya, Lisa R Yanek, Taryn F Moy, Lewis C Becker
Journal: Circulation (2010)

Background: Exercise-induced ischemia on myocardial perfusion imaging is associated with an increased risk of coronary artery disease (CAD) events in individuals referred for symptoms and/or with k...
Abstract 4665: CASPER: Study Design and Preliminary Results in Probands from the Cardiac Arrest Survivors with Preserved Ejection Fraction Registry
Authors: Andrew D Krahn, David H Birnie, Jeffrey S Healey, Christopher S Simpson, Jean Champagne, Martin Gardner, Shubhyan Sanatani, Vijay Chauhan, Michael H Gollob
Journal: Circulation (2008)