tbuckley/cabot-search huggingface dataset:
Abstract 3098: ERCC1 gene copy number variations in resected non-small cell lung cancer
Authors: Luc Friboulet, Ken A. Olaussen, Alexander Valent, Ximing Tang, Tao Tang, Yuanyuan Li, Carmen Behrens, Philippe Vielh, Angélique Robin, Aïcha Goubar, Pierre Validire, Ignacio Wistuba, Jean-Charles Soria
Journal: Cancer Research (2012)

Abstract Introduction: ERCC1 allows removal of branched DNA structures at essential steps in DNA repair pathways such as Nucleotide Excision Repair (NER), Fanconia-dependent Interstrand Cross-Link Repair (ICL-R), long-patch base excision repair (BER), and Single Strand Annealing (SSA). ERCC1 expression is a prognostic and predictive biomarker of chemotherapy effect in NSCLC. The most frequent method to determine ERCC1 status is the evaluation of gene expression (IHC or RT-PCR). Here, we studied the prevalence of ERCC1 copy number variation (CNV) using FISH. Methods: FISH was performed with Poseidon™ dual color probe set, ERCC1 (19q13) and ZNF443 (19p13) on a panel of 17 NSCLC cell lines and 324 FFPE tumor samples from resected NSCLC patients (103 from IGR, Villejuif, France, 221 from MDACC, Houston, USA). Gene amplification (GA) and high polysomy (HP) were defined following actual consensus rules for EGFR assessment. Results: ERCC1 copy number was increased (&amp;gt;2) in a large majority of cell lines (13/17) of which three displayed gene amplification (GA) (H2342, CN=5; H1299, CN&amp;gt;12; HOP62, CN&amp;gt;15). In human samples, overall ERCC1 gene abnormalities were detected in 65 cases (20.1%) including 31 GA (6.9%, the majority with clusters) and 34 HP (13.7%, more frequent in squamous cell carcinomas). In patients with ERCC1 expression status available (immunohistochemistry) we found a non-significant trend for higher ERCC1 expression in HP patients compared to GA and low CNV patients (P=0.06). Despite a 3-fold increase in IC50 of cisplatin in cell lines with ERCC1 gene amplification compared to normal cells (with no CNV) the ERCC1 FISH status seemed unable to predict chemosensitivity in resected NSCLC patients. In patients not treated with chemotherapy, DFS was significantly longer in patients with normal ERCC1 FISH status of the tumor compared to patients with ERCC1 gene amplification (P=0.02). Conclusion: ERCC1 copy number variation is a frequent event in NSCLC and could reflect genomic instability, but the clinical relevance of this observation needs further investigation. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 103rd Annual Meeting of the American Association for Cancer Research; 2012 Mar 31-Apr 4; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2012;72(8 Suppl):Abstract nr 3098. doi:1538-7445.AM2012-3098
TUMORS OF THE PARATHYROID GLAND
Authors: CLARENCE G. TOLAND
Journal: JAMA (1931)

During recent years the parathyroid glands have come into rather special prominence owing to their apparent functional connection with calcium metabolism and tetany. In consequence, parathyroid tumors, instead of being pathologic curiosities, have assumed a more important clinical rôle. I have recently observed two cases of these fairly rare tumors, but before giving the details I will give a short synopsis of the present clinical aspects of the parathyroids and their pathology. The parathyroids were first accurately described in 1880 by Sandström,<sup>1</sup>who apparently, however, held the view that they were undeveloped embryonic thyroid tissue. In 1898, Gley<sup>2</sup>showed that tetany following parathyroidectomy did not occur unless the external parathyroids were removed, although they were still considered as part of the thyroid gland. The parathyroids may be intrathyroid or extrathyroid. According to Guleke<sup>3</sup>the human parathyroid may occur in three types: (1) the compact type, as seen
DATURA POISONING IN THE FEDERATED MALAY STATES
Authors: J. D. Gimlette
Journal: BMJ (1903)

agL '137 morbid.cutaneous manifestations is probably more complez than appears on the surface.As in the production of all disease, various factors are at work, some of which are at present unknown.Recent study of the blood and of im- munity points the way, I think, in the direction of a solution.28Behrend's view that drug eruptions may be the result of the production of toxins in the body is probably correct in some cases.It receives support from the fact that eruptions may occur some time after the exhibition of the drug.The rashes due to antitoxins may be mentioned in this connexion.The sweat-excretory view was put forward long ago by Trousseau.29Other hypothe3es are that drug eruptions depend on changes in the tissues themselves or in their vessels.Others rely on the peripheral nerves, on the vasomotor centres, on trophic nerve influence.As to the last named physiologists state there is no proof of the existence of such.Howbeit, it can be safely said at the present juncture that the intimate mechanism of drug eruptions is not known.Normally, the tissues are bathed in sodium chloride, but may not the use of bromides and iodides lead to rashes by substituting bromine and iodine for the chlorine?I will conclude with the practical application of a knowledge of drug eruptions.I have already insisted on the part played by zoster in the Manchester epidemic.Sir William Gowers relates an interesting instance bearing on this point.30In a case of peripheral neuritis in a young Indian civil servant, arsenical pigmentation gave the clue to his disorder.It was ultimately found that there had been a prolonged attempt to poison the patient, iti India.A curious fact, too, was that about the commencement of his illness, which had been diagnosed as intermittent fever, he had had an attack of shingles.I need hardly tell you that in India arsenic is largQly used as a poison, and the same custom apparently prevails in other Eastern apd semi-Eastern countries.3'
Molecular Mechanisms Implicated In The Sensitization And Tolerance: Olive Pollen Model
Authors: B. Cárdaba, M. Aguerri, F. Florido, E. Martín, J. Quiralte, J. Delgado, A. Miranda, J. López, R. García, S. Gallardo, P. Palomino, C. Lahoz
Journal: Journal of Allergy and Clinical Immunology (2010)
Anesthesia for Colonoscopy: Too Much of a Good Thing?
Authors: Karen J. Wernli, John M. Inadomi
Journal: JAMA Internal Medicine (2013)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Internal Medicine HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Internal Medicine journal
PEANUTS AS FOOD
Authors: B. F. Williamson
Journal: JAMA (1918)

<h3>To the Editor:</h3> —I have read with a great deal of interest the food articles appearing inThe Journalin Current Comment. March 23, special reference was made to peanuts, and on page 1004, April 6, to the yield of food per acre. This comment referred especially to corn, and stated that 35 bushels of corn per acre produce 150 pounds of protein and more than 3,000,000 units of energy. Further reference was made to the soy bean. The peanut is unusually interesting for several reasons: First, it produces an average of 1,000 pounds of nuts per acre, containing 2,000,000 units of energy and approximately 220 pounds of protein. If the peanuts are properly handled, they will produce about 500 pounds of peanut flour, which contains 44 per cent. of protein and 7.5 per cent, of fat. This peanut flour blends readily with all flour and flour substitutes as well
Methotrexate Therapy for Psoriasis-Reply
Authors: Eugene M. Farber
Journal: JAMA (1988)

<h3>In Reply.—</h3> Drs Shupack and Webster<sup>1</sup>have made a contribution by calling to our attention that the use of methotrexate for psoriasis is a two-edged sword. We know the benefits of this treatment, but it is important to bear in mind its risks. The two additional case reports of methotrexate-associated pancytopenia underscore the concern for proper assessment of renal function along with periodic hematologic and hepatic evaluations of patients receiving long-term methotrexate therapy. These reports support Drs Shupack and Webster's admonition for avoidance of the drug in patients with renal insufficiency or hematologic instability and for discontinuation of methotrexate use when concomitant drug therapy may affect renal function by drug interaction. In the patient reported by Drs Grigg and Hare, her fatal pancytopenia was considered multifactorial in nature. Increased drug levels of methotrexate resulted partly from impaired excretion due to altered fluid intake and dehydration, in addition to displacement
Are Clinical Trials Cost-effective?
Authors: David Adcock
Journal: JAMA (1990)

To the Editor.—  In the useful article on the cost-effectiveness of clinical trials, 1 the reader is left with the impression that clinical trials are a good investment, even though only a few, selected trials were studied. The author is careful to point out that this was not a random selection of trials, but that's the problem, it should have been.  Presumably, there are clinical trials that do not result in the development of a useful health care intervention (and also do not prevent the use of ineffective medical care activities). These studies also have costs, possibly quite large. How are these costs to be handled? Should they be considered indirect costs of the trials that produce useful results? A cost-effectiveness study of clinical trials would be more convincing if it were done on a randomly selected group of trials?
Sleep apnea is associated with bronchial inflammation and continuous positive airway pressure–induced airway hyperresponsiveness
Authors: Gilles Devouassoux, Patrick Lévy, Eliane Rossini, Isabelle Pin, Michèle Fior-Gozlan, Mireille Henry, Daniel Seigneurin, Jean-Louis Pépin
Journal: Journal of Allergy and Clinical Immunology (2007)
Serum IgE levels, atopy, and asthma in young adults: results from a longitudinal cohort study
Authors: J. K. Peat, B. G. Toelle, J. Dermand, R. Berg, W. J. Britton, A. J. Woolcock
Journal: Allergy (1996)

To explore the natural history of asthma and its relation to allergic responses, we examined the relation between total serum IgE in early adulthood and a history of respiratory symptoms, airway hyperresponsiveness (AHR), and atopy during childhood. We studied 180 subjects aged 18-20 years who had been studied since the age of 8-10 years. We measured wheeze in the previous year by questionnaire, AHR by histamine inhalation test, atopy by skin prick tests, and serum IgE levels by immunoassay. Subjects with AHR in early adulthood had higher IgE levels (mean 257.0 IU/ml) than subjects with past AHR (mean 93.3 IU/ml) or with lifelong normal responsiveness (mean 67.6 IU/ml) (P < 0.001). Subjects who had symptoms had higher IgE levels (mean 125.9 IU/ml) than those who were lifelong asymptomatic (mean 63.1 IU/ml) (P < 0.001). Recent wheeze, AHR, and allergic sensitization all had a positive relation to serum IgE, but IgE was not more predictive of AHR than skin prick tests. The finding that young adults who are sensitized to common allergens are highly likely to have AHR even in the absence of symptoms is further evidence of the fundamental role of IgE-mediated responses in the natural history of AHR throughout childhood and into adulthood.
Self management of asthma: Authors' reply
Authors: I. Charlton, G. Charlton, J. Broomfield, M. Mullee
Journal: BMJ (1991)

in sleep onset latency between placebo (median 11, range 2-49 mins) and salmeterol 50 .sgtwice daily (13, 5-53 mins).In fact the major determinant of the observed decrease in wakefulness and drowsiness between salmeterol 50 ig twice daily and placebo was a reduction in intervening wake- fulness throughout the night.Mr Sarin and colleagues suggest that the effect of salmeterol 100 Fg twice daily on sleep quality was little different from that of salmeterol 50 [sg twice
Lack of agreement between the plasma lipid-based criteria and apoprotein B for the diagnosis of familial combined hyperlipidemia in members of familial combined hyperlipidemia kindreds
Authors: Juan Pablo del Rincon Jarero, Carlos A. Aguilar-Salinas, Luz E. Guill[eacute]n-Pineda, Francisco J. G[oacute]mez P[eacute]rez, Juan A. Rull
Journal: Metabolism (2002)
Dichloroacetate Reduces Diaphragmatic Lactate Formation But Impairs Respiratory Performance
Authors: RUSS CIUFO, ANTHONY DIMARCO, DANIEL STOFAN, DAVID NETHERY, GERALD SUPINSKI
Journal: American Journal of Respiratory and Critical Care Medicine (2001)

Previous studies have found that administration of dichloroacetate (DCA), an agent that reduces lactic acid generation, increases limb muscle endurance. The purpose of the present study was to determine if this agent also improves respiratory muscle performance. To examine this issue, we determined the effect of DCA administration on the response to application of a large inspiratory resistive load (32,000 cm H2O / L / s) in unanesthetized decerebrate rats. Studies were carried out in four groups of animals: saline unloaded, DCA unloaded, saline loaded, and DCA loaded. DCA was administered as 100 mg / kg, given intravenously over 30 min, prior to respiratory loading. We found that diaphragm lactate levels were higher in saline-treated loaded animals than in unloaded controls and that DCA administration prevented loading-induced increases in diaphragm lactate (p < 0.001). DCA-treated animals tolerated loading poorly, however, with a more rapid reduction in diaphragm pressure generation and a shorter time to respiratory arrest (42 ± 3 min) than for saline-treated animals (57 ± 3 min, p < 0.01). These data indicate that DCA administration decreases the tolerance to loaded breathing despite reductions in diaphragm lactate concentrations. We speculate that suppression of lactate formation by DCA may impair metabolic regulation within the diaphragm during resistive loaded breathing.
Oxidant effects on epithelial Na,K-ATPase gene expression and promoter function.
Authors: C H Wendt, R Sharma, R Bair, H Towle, D H Ingbar
Journal: Environmental Health Perspectives (1998)

The lung epithelium resorbs alveolar fluid through combined action of sodium channels and the sodium pump, Na,K-ATPase. The lung often is exposed to hyperoxia in disease states and hyperoxia generates a mixture of reactive oxygen species. In vivo and in vitro exposure of rat lung and alveolar type II cells, respectively, increases gene expression of both alpha-1 and beta-1 subunits of the sodium pump. In contrast to the primary type II cells, several type II cell lines did not increase sodium pump gene expression with hyperoxia, but the renal tubular epithelial MDCK cell line did. Using promoter-receptor constructs transfected into MDCK cells, hyperoxia did not markedly increase transcription of the alpha-1 subunit but doubled transcription of the beta-1 subunit gene. Using 5'-deletion constructs, the region required for the beta-1 increase was localized to a 40-base pair region from -44/-84. The hyperoxic responsiveness of this region was confirmed using constructs with one or two copies of this region placed in minimal promoter-luciferase reporters. This 5' promoter region contains a consensus binding sequence for SP-1, a basal transcription factor but not for binding of other known transcription factors. Thus, hyperoxia induces Na,K-ATPase beta-1 promoter transcription, likely acting through a novel mechanism.
1095-202 Can we predict sudden death after atrial repair for transposition of the great arteries?
Authors: Janneke A Kammeraad, Seshadri Balaji, Carolien H van Deurzen, Margreet T Bink-Boelkens, Jaapn Ottenkamp, Willem A Helbing, Jan Lam, Martha A Sobotka-Plojhar, Otto Daniels, Narayanswami Sreeram
Journal: Journal of the American College of Cardiology (2004)
Regulation of Second Messengers Associated with Airway Smooth Muscle Contraction and Relaxation
Authors: HAKON HAKONARSON, MICHAEL M. GRUNSTEIN
Journal: American Journal of Respiratory and Critical Care Medicine (1998)

Section:ChooseTop of pageAbstract <<CHARACTERISTICS OF G PROT...STRUCTURAL AND FUNCTIONAL...G PROTEIN–COUPLED EFFECTO...DESENSITIZATION OF G PROT...REGULATION OF SECOND MESS...REGULATION OF INS(1,4,5)P...BETA-ADRENOCEPTOR REGULAT...ALTERED TRANSMEMBRANE SIG...ReferencesCITING ARTICLES
Abstract 1271: Alcohol intake and breast cancer in the European Prospective investigation into Cancer and Nutrition (EPIC) study
Authors: Isabelle Romieu, Chiara Scoccianti, Veronique Chajes, Jordi De Batlle, Sabina Rinaldi
Journal: Cancer Research (2014)

Abstract Context: Alcohol intake has been positively associated to breast cancer among both pre and postmenopausal women; however results are inconclusive with regards to tumor hormonal receptor status, and potential modifying factors such as age at start drinking, and dietary fiber. Objective: To investigate the relation between alcohol intake and the risk of breast cancer using data from the European Prospective Investigation into Cancer and Nutrition (EPIC). Design, Setting, and Participants: Prospective observational study of 334,850 women mostly aged 35-70 years at baseline enrolled in the ten countries of the EPIC study and followed up for 11.0 years on average. Information on alcohol intake at baseline and average lifetime alcohol intake were calculated from country-specific dietary and lifestyle questionnaires. Main Outcome Measures: Hazard ratios (HR) of developing invasive breast cancer according to hormonal receptor status. Results: During 3,670,439 person-years, 11,576 incident breast cancer cases were diagnosed. Increasing alcohol intake was significantly related to breast cancer risk, for each 10g/day increase in alcohol intake the HR increased by 4.2% (95% CI, 2.7% -5.8%). Taking 0 to 5g/day as reference, alcohol intake of &amp;gt;5 to 15 g/day was related to a 5.9% increase of breast cancer risk (95% CI, 1% -11%). A significant increasing trend was observed between alcohol intake for ER+/PR+, ER-/PR-, HER2- and ER-/PR-/HER2-tumors. The risk of breast cancer appeared stronger among women who started drinking prior to first full-time pregnancy and among drinkers (&amp;gt;15g/day) with low intake of fiber. Conclusions: Our results confirm the association between alcohol intake and breast cancer risk, and suggest that some other risk factors such as fiber intake, may modulate this association. Women should be advised to control their alcohol intake, and increase their intake of fiber. Citation Format: Isabelle Romieu, Chiara Scoccianti, Veronique Chajes, Jordi De Batlle, Sabina Rinaldi. Alcohol intake and breast cancer in the European Prospective investigation into Cancer and Nutrition (EPIC) study. [abstract]. In: Proceedings of the 105th Annual Meeting of the American Association for Cancer Research; 2014 Apr 5-9; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2014;74(19 Suppl):Abstract nr 1271. doi:10.1158/1538-7445.AM2014-1271
Disease Risk Factors Identified Through Shared Genetic Architecture and Electronic Medical Records
Authors: Li Li, David J. Ruau, Chirag J. Patel, Susan C. Weber, Rong Chen, Nicholas P. Tatonetti, Joel T. Dudley, Atul J. Butte
Journal: Science Translational Medicine (2014)

Twenty-six traits were associated with diseases through similarities in genetic variation and validated from electronic medical records.
Fallibility of Urine Drug Screens in Monitoring Methadone Programs
Authors: Edward Gottheil
Journal: JAMA (1976)

Urine specimens containing five different drugs, each at three levels of concentration with zero to five drugs in a specimen, were sent to two "approved" laboratories. In only 46.9% and 13.8%, respectively, were all drugs present correctly identified and no false-positive results reported. With some allowances, the results improved to 53.8% and 49.4%. If these tests are to be continued then (1) the fallibility of these tests should be known by all treatment personnel, (2) laboratories should be licensed rather than merely approved, and (3) maintenance of the license should be made contingent on passing "blind" proficiency tests.
Folate Balance in Dietary-Induced Megaloblastic Anemia
Authors: Edward R. Eichner, H. Irving Pierce, Robert S. Hillman
Journal: New England Journal of Medicine (1971)

In alcoholic subjects megaloblastic hemopoiesis rapidly develops during dietary deprivation and ethanol ingestion. To study the interaction of poor diet, depleted body folate stores and ethanol, two subjects in whom megaloblastic hemopoiesis previously developed within three weeks on a deficient diet combined with ethanol were restudied on a low-folate diet alone. The sequence of hematologic changes differed from that previously described. The curve for serum folate depletion was biphasic; the first phase reflected decreased dietary folate, and the second phase reflected folate store depletion. Not until the serum folate reached a plateau did bone-marrow changes occur. Peripheral blood abnormalities did not appear until after the marrow was megaloblastic for one to two weeks. In this study, megaloblastic hemopoiesis appeared in five to 10 weeks, as compared to 19 weeks in Herbert's classic study. Although ethanol seems to accelerate megaloblastic change, this study confirms the critical role of folate stores in determining the onset of tissue folate deficiency on an inadequate diet.
Causes and Consequences of Chorioamnionitis
Authors: Richard L. Naeye
Journal: New England Journal of Medicine (1975)

Acute inflammations of the fetal membranes (chorioamnionitis) and umbilical cord (funisitis) often have no adverse effects on the mother or fetus, but in some cases they are associated with congenital pneumonia, early onset of labor and clinical evidence of maternal infection. Pathogenic bacteria are easily cultured from many patients, but in others the chorioamnionitis has appeared to be sterile, leading to speculation that meconium or other noninfectious agents might be responsible for the inflammation. Recent studies have generated new evidence that bacteria are usually responsible for the disorder. Lauweryns has found that a number of bacteria produce the lesions whereas . . .
Serratia marcescens Bacteremia From Contaminated Pressure Transducers
Authors: Leigh G. Donowitz
Journal: JAMA (1979)

Primary<i>Serratia marcescens</i>bacteremia developed in 17 patients in an intensive care unit after exposure to pressure monitoring devices. A study showed that all of the transducer heads were contaminated with<i>S marcescens</i>, and prospective culturing of 110 pressure monitoring lines disclosed a 24% rate of contamination with the same organism. Hand contamination occurs at the time the equipment is initially assembled; in five of eight trials, transmission was shown experimentally to occur by direct inoculation of open ports. Routine disinfection of the transducer heads with glutaraldehyde not only effectively decontaminated all pressure monitoring lines in use, but also controlled the outbreak. (<i>JAMA</i>242:1749-1751, 1979)