Low-Dose Thiazide and Bone Density
Authors: Hosam K. Kamel
Journal: Annals of Internal Medicine (2002)

Letters5 February 2002Low-Dose Thiazide and Bone DensityHosam K. Kamel, MDHosam K. Kamel, MDMedical College of WisconsinMilwaukee, WI 53295Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-136-3-200202050-00018 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:LaCroix and colleagues (1), in a 3-year randomized, controlled trial, demonstrated that low-dose hydrochlorothiazide increased bone density in elderly normotensive men and women. They subsequently recommended considering hydrochlorothiazide in osteoporosis prevention programs. I believe this recommendation is too general and deserves further clarification.The beneficial effect of hydrochlorothiazide on bone is probably related to its action on kidney tubules to promote calcium reabsorption. Urinary calcium excretion increases in postmenopausal women. This physiologic phenomenon, also known as postmenopausal renal calcium leak, has been attributed to reduced tubular reabsorption of calcium secondary to decreased estrogen effect on kidney tubules ...References1. LaCroix AZ, Ott SM, Ichikawa L, Scholes D, Barlow WE. Low-dose hydrochlorothiazide and preservation of bone mineral density in older adults. A randomized, double-blind, placebo-controlled trial. Ann Intern Med. 2000;133:516-26. [PMID: 11015164] LinkGoogle Scholar2. Nordin BE, Horowitz M, Need A, Morris HA. Renal leak of calcium in post-menopausal osteoporosis. Clin Endocrinol (Oxf). 1994;41:41-5. [PMID: 8050130] CrossrefMedlineGoogle Scholar3. Heaney RP, Recker RR, Ryan RA. Urinary calcium in perimenopausal women: normative values. Osteoporos Int. 1999;9:13-8. [PMID: 10367024] CrossrefMedlineGoogle Scholar4. McKane WR, Khosla S, Burritt MF, Kao PC, Wilson DM, Ory SJ, et al . Mechanism of renal calcium conservation with estrogen replacement therapy in women in early postmenopause—a clinical research center study. J Clin Endocrinol Metab. 1995;80:3458-64. [PMID: 8530583] MedlineGoogle Scholar5. . NIH Consensus conference. Optimal calcium intake. NIH Consensus Development Panel on Optimal Calcium Intake. JAMA. 1994;272:1942-8. [PMID: 7990248] CrossrefMedlineGoogle Scholar Author, Article, and Disclosure InformationAffiliations: Medical College of WisconsinMilwaukee, WI 53295 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoLow-Dose Hydrochlorothiazide and Preservation of Bone Mineral Density in Older Adults Andrea Z. LaCroix , Susan M. Ott , Laura Ichikawa , Delia Scholes , and William E. Barlow Low-Dose Thiazide and Bone Density Andrea Z. LaCroix and Susan M. Ott Metrics Cited byThe Effect of Thiazides on Bone Markers, Bone Mineral Density and FracturesLow fatness, reduced fat intake and adequate plasmatic concentrations of LDL-cholesterol are associated with high bone mineral density in women: a cross-sectional study with control groupThiazide Diuretics Directly Induce Osteoblast Differentiation and Mineralized Nodule Formation by Interacting with a Sodium Chloride Co-Transporter in BoneApplications of nuclear quadrupole resonance spectroscopy in drug developmentStructure-activity study of thiazides by magnetic resonance methods (NQR, NMR, EPR) and DFT calculationsCurrent Awareness 5 February 2002Volume 136, Issue 3Page: 252KeywordsBoneBone densityCalciumElderlyEstrogensExcretionHyperparathyroidismHypertensionKidneysOsteoporosis ePublished: 5 February 2002 Issue Published: 5 February 2002 Copyright & PermissionsCopyright © 2002 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...