tbuckley/cabot-search huggingface dataset:
“Double jeopardy”: twin problems associated with an esophageal self-expanding metal stent
Authors: S. Menon, L. Mathew, A. Munasinghe, J. Butterworth
Journal: Endoscopy (2008)

A 63-year-old man underwent placement of a self-expanding metal stent (SEMS) for palliation across a malignant esophageal stricture due to adenocarcinoma of the lower esophagus. He also underwent palliative chemotherapy with good radiological regression of the original tumor. He presented with dyspeptic symptoms 3 months after stent placement, and a gastroscopy revealed the stent to be lying free in the stomach ([Fig. 1]). An attempt was not made to retrieve the stent at the time. He presented again 2 weeks later with abdominal pain and vomiting. An abdominal radiograph revealed features of small-bowel obstruction with two fragments of the stent seen at different levels in the small bowel ([Fig. 2]). A computed tomography scan of the abdomen confirmed this finding ([Fig. 3]). The distal fragment was identified to be lying in the distal ileum, with the proximal fragment in the distal jejunum/proximal ileum. Laparotomy revealed that the stent had indeed fractured into two fragments and that the distal end of the stent lay embedded in the ileal wall with a localized perforation ([Fig. 4]). A limited ileal resection and end-to-end anastomosis was performed. The patient had an uneventful recovery.
Morbidity Following Radiological Procedures
Authors: G. Ansell
Journal: BMJ (1966)

Hg, the pulse remaining about 60 per minute throughout.At this stage he fell asleep.Although his blood-pressure continued to rise slowly, it did not regain the pre-operative figure for 36 hours.Eleven days later (15 days after discontinuing phenelzine) and following the same premedication, his retinal detachment was operated on, this time without any hypo- tensive episodes.Though the patient was also taking perphenazine for an equal time, it is considered that the phenelzine, with its known action in potentiating other drugs, was the agent responsible.-Iam, etc.,
DIVERTICULITIS OF THE SIGMOID
Authors: W. J. Mayo
Journal: BMJ (1929)

ALRJTUspart of the bowel in which there are diverticula?Doubtless many others will alise.Diverticulitis is a complaint that can be controlled if it is recogn-ized eally, though if allowed to take its course unchecked-it becomes disabling; and dangerous.It behoves us, therefore, as practitioners, to make ourselves as familiar as w%ve can w%ith th-e disease.anid especially w-ith the early stages.It is hoped that suclh a discussion as-that I have thle honour to openi n-ow nmay dco somethilg more to fore- war-n and forearm the profession at large against its onset.APPENDIX I.At iRuthin Castle the colon had been observed with a barium meal or enema in 3,208 patieints; 313 (roughly 10 per cent.) of these were the subjects of diverticulosis, and in 70 the disease.had progressed to the stage of diverticulitis.Of these 70 patients, 54 were men and 16 women.The average age was 56; 21, rather less than one-third, of them were obese.There was an association of the disease with septic teeth, lumbar spondylitis, lumbago, sciatica, and apparently herpes of the nerves arising from the dorsal and fiirst lunmbar segments.Cancer was present in 4 cases-2 of the rectum and 2 of the sigmoid.This lent no particular support to the view that diverticulitis was a frequent cause of cancer.(Operations done on the advice of a physician at a convenient time were not dangerous.Of 5 so treated in this series there was no mortality, and the complaint was relieved in all.The heavv mortality quoted in the literature-12 to 25 per cent.-inclutded those cases which had been unrecognized and un- treated.Out of the 70 cases, 14 were now dead; 2 of these died from diverticulitis.One had vesical fistula and abscess; this patient had continued to take paraffin, but had omitted douching for three years.The other one died after a perforation.Twelve had died from other diseases.Fifty-two patients were kniown to have kept well as regards the bowel; of f5 there was no news.Lantern slides were shown illustrating the development from diverticulosis to diverticulitis and results of treatment in diverticulitis.APPENDIX II.The nomenclature of this disease is cumbrous.I have con- sulted various authorities, including those who adhere to the B.N. A. nomenclature and those who do not.Whilst most condemn the terms we use and look for better ones, by others I am griven to understand that the reform of medical terms is a domain where angels fear to tread.This angelic timidity is perhaps one reason which has led me to use all the old names.I may, however, mention that the Greek word ad caos (Latin saccus.)is, I am assured, as respectable etymologically as the word diverticulum, or more so.From it could be derived Eniglish words: sac, saccous or saccal, saccosis, saccitis, pre- saccal state.Dr. Cuthbert Morton pointed out to me that the use of these terms instead of diverticulum, divert iculous or diverticular, diverticulosis, diverticulitis, and prediver ticul ar state would have saved nearly half a column in a recent article which occupied eleven columns of the Lancet.
Hailey-Hailey disease: exacerbation by scabies
Authors: R. Gerdsen, C. Hartl, S. Christ, M. Uerlich, R. Bauer, T. Bieber
Journal: British Journal of Dermatology (2001)

Sir, Familial benign chronic pemphigus was first described by Hailey and Hailey in 1939.1 The disease is dominantly inherited and is characterized clinically by vesiculopustules, crusted erosions or expanding circinate plaques typically appearing at the sides of the neck, axillae, groins or perineum.2 The underlying gene defect has been localized to chromosome 3 (3q21) with mutations in the gene ATP2C1 encoding a novel Ca2+ pump.3 A 58‐year‐old woman was referred to our clinic with pruritic skin lesions on her trunk and limbs. She had been diagnosed as having Hailey–Hailey disease 10 years earlier, with recurrent erosive skin lesions predominantly in intertriginous areas. She had previously been treated with topical steroids and radiotherapy to both inguinal areas. In addition, she had received several courses of oral glucocorticosteroids, which had caused insulin‐dependent diabetes mellitus. Following a worsening of her condition in the 6 months prior to presentation, she had been treated with up to 40 mg of methylprednisolone daily.
Predictors of Long-Term Survival After Coronary Artery Bypass Grafting Surgery
Authors: David M. Shahian, Sean M. O'Brien, Shubin Sheng, Frederick L. Grover, John E. Mayer, Jeffrey P. Jacobs, Jocelyn M. Weiss, Elizabeth R. DeLong, Eric D. Peterson, William S. Weintraub, Maria V. Grau-Sepulveda, Lloyd W. Klein, Richard E. Shaw, Kirk N. Garratt, Issam D. Moussa, Cynthia M. Shewan, George D. Dangas, Fred H. Edwards
Journal: Circulation (2012)

Most survival prediction models for coronary artery bypass grafting surgery are limited to in-hospital or 30-day end points. We estimate a long-term survival model using data from the Society of Thoracic Surgeons Adult Cardiac Surgery Database and Centers for Medicare and Medicaid Services.The final study cohort included 348 341 isolated coronary artery bypass grafting patients aged ≥65 years, discharged between January 1, 2002, and December 31, 2007, from 917 Society of Thoracic Surgeons-participating hospitals, randomly divided into training (n=174 506) and validation (n=173 835) samples. Through linkage with Centers for Medicare and Medicaid Services claims data, we ascertained vital status from date of surgery through December 31, 2008 (1- to 6-year follow-up). Because the proportional hazards assumption was violated, we fit 4 Cox regression models conditional on being alive at the beginning of the following intervals: 0 to 30 days, 31 to 180 days, 181 days to 2 years, and >2 years. Kaplan-Meier-estimated mortality was 3.2% at 30 days, 6.4% at 180 days, 8.1% at 1 year, and 23.3% at 3 years of follow-up. Harrell's C statistic for predicting overall survival time was 0.732. Some risk factors (eg, emergency status, shock, reoperation) were strong predictors of short-term outcome but, for early survivors, became nonsignificant within 2 years. The adverse impact of some other risk factors (eg, dialysis-dependent renal failure, insulin-dependent diabetes mellitus) continued to increase.Using clinical registry data and longitudinal claims data, we developed a long-term survival prediction model for isolated coronary artery bypass grafting. This provides valuable information for shared decision making, comparative effectiveness research, quality improvement, and provider profiling.
THE ACID MUCOPOLYSACCHARIDE AND 5-HYDROXYTRYPTAMINE CONTENT OF HUMAN THROMBOCYTES IN RHEUMATOID ARTHRITIC AND NONARTHRITIC INDIVIDUALS*
Authors: Grace P. Kerby, S. M. Taylor
Journal: Journal of Clinical Investigation (1959)

1 As in previous investigations (2), three groups of patients were studied.The groups were as previously defined and consisted essentially of Group A with no evidence of inflammatory disease, Group B with significant but nonrheumatoid inflammatory processes and Group C with unequivocal active rheumatoid arthritis.
Preliminary pneumoperitoneum facilitates transgastric access into the peritoneal cavity for natural orifice transluminal endoscopic surgery: A pilot study in a live porcine model
Authors: C.-W. Ko, E. Shin, J. Buscaglia, J. Clarke, P. Magno, S. Giday, S. Chung, P. Cotton, C. Gostout, R. Hawes, P. Pasricha, A. Kalloo, S. Kantsevoy
Journal: Endoscopy (2007)

Safe entrance into the peritoneal cavity through the gastric wall is paramount for the successful clinical introduction of natural orifice transluminal endoscopic surgery (NOTES). The aim of the study was to develop alternative safe transgastric access to the peritoneal cavity.We performed 11 survival experiments on 50-kg pigs. In sterile conditions, the abdominal wall was punctured with a Veress needle. The peritoneal cavity was insufflated with 2 L carbon dioxide (CO (2)). A sterile endoscope was introduced into the stomach through a sterile overtube; the gastric wall was punctured with a needle-knife; after balloon dilation of the puncture site, the endoscope was advanced into the peritoneal cavity. Peritoneoscopy with biopsies from abdominal wall, liver and omentum, was performed. The endoscope was withdrawn into the stomach. The animals were kept alive for 2 weeks and repeat endoscopy was followed by necropsy.The pneumoperitoneum, easily created with the Veress needle, lifted the abdominal wall and made a CO (2)-filled space between the stomach and adjacent organs, facilitating gastric wall puncture and advancement of the endoscope into the peritoneal cavity. There were no hemodynamic changes or immediate or delayed complications related to pneumoperitoneum, transgastric access, or intraperitoneal manipulations. Follow-up endoscopy and necropsy revealed no problems or complications inside the stomach or peritoneal cavity.Creation of a preliminary pneumoperitoneum with a Veress needle facilitates gastric wall puncture and entrance into the peritoneal cavity without injury to adjacent organs, and can improve the safety of NOTES.
Right ventricular outflow tract assessment by cross-sectional echocardiography in tetralogy of Fallot.
Authors: R L Caldwell, A E Weyman, R A Hurwitz, D A Girod, H Feigenbaum
Journal: Circulation (1979)

Cross-sectional echocardiographic (CSE) studies were obtained in 29 children with tetralogy of Fallot. In this study we evaluated the capability of CSE to record the right ventricular outflow tract (RVOT) and compared the severity of infundibular obstruction determined by CSE with cineangiographic (cine) determinations. In addition, we examined capabilities of CSE and M-mode echocardiography (M-mode) to record the diagnostic features of tetralogy of Fallot, including RVOT obstruction, aortic overriding, ventricular septal defect, and presence of the pulmonary valve. An excellent correlation (r = 0.925) was found for the combined pre- and post-repair patients studied by CSE vs cine, while the correlation (r = 0.805) for M-mode was not as good. The difference was even more striking for the unrepaired patients, in which the correlation (r = 0.746) for CSE was much better than for M-mode (r = 0.374). In the unrepaired patients, CSE allowed easier detection of the ventricular septal defect than M-mode (95% for CSE vs 76% for M-mode). The pulmonary valve was recorded in 90% by CSE, but in only 26% by M-mode. Aortic overriding was recorded in all unrepaired patients both by CSE and M-mode. These data indicate that CSE is better than M-mode for recording the RVOT dimensions, ventricular septal defect, and the pulmonary valve in unrepaired patients with tetralogy of Fallot.
Incidence of Pancreatic Cancer-Reply
Authors: R.S. Lin
Journal: JAMA (1981)

In Reply.—  Although secular changes in the incidence of cancer are often difficult to document in view of the paucity of relevant statistics, the available data suggest that pancreatic cancer increased rather steadily between the second and sixth decades of this century. Using US mortality data, Devesa and Silverman 1 observed substantial increases in pancreatic cancer death rates among both whites and nonwhites between 1935 and 1971. Krain 2 calculated a threefold increase in pancreatic cancer mortality between 1920 and 1965 in the United States and a number of other countries. Data as yet unpublished from the vital records of the state of Maryland indicate that the death rate from pancreatic cancer among our citizens increased during the interval between 1965 and 1979.  A comparison of statistics derived from the second and third National Cancer Surveys also disclosed increases in the incidence of pancreatic cancer among males and females of
Rheumatology and Immunology
Authors: Burton J. Grossman
Journal: JAMA (1980)

The list of contributors to this handsome 8 1/2×11-in volume reads like a<i>Who's Who</i>of the leading authorities in rheumatology and immunology. The text is well supplied with tables, charts, photomicrographs, roentgenograms, and schematic drawings complementing well-written, well-researched presentations on a wide range of subjects in the fields of rheumatology and immunology. The rheumatology section provides a systematic approach to the basic subject matter with major headings on regional structure and function, diagnostic procedures, differential approach to major rheumatic syndromes, and specific articular and connective-tissue diseases. The immunology section is divided into the following categories: concepts and diagnostic procedures, differential approach to major immunologic syndromes, and specific immunologic diseases. Each subsection, within the major sections, is written by an authority or authorities in the specific field and provides a small number of the basic references on the subject. A fine example of the clarity and excellent organization of material
Clinically localised prostate cancer
Authors: Timothy J Wilt, Ian M Thompson
Journal: BMJ (2006)

Prostate cancer is the most commonly diagnosed cancer in United Kingdom men.w1 In 2002 it was diagnosed in 32 000 men, and more than 10 000 deaths were attributed to it. Its incidence increased with the introduction of the prostate specific antigen (PSA) blood test, and disease specific mortality has declined. This review provides evidence about risk factors, prevention, detection, natural course, and treatment, with a focus on clinically localised disease, to guide primary care doctors. #### Summary points #### Data sources and selection criteria
Ultraviolet A1 (340-400 nm) phototherapy for cutaneous T-cell lymphoma
Authors: Heidi Plettenberg, Helger Stege, Mossaad Megahed, Thomas Ruzicka, Yuko Hosokawa, Takuo Tsuji, Akimichi Morita, Jean Krutmann
Journal: Journal of the American Academy of Dermatology (1999)
A Transgenic-Mouse Model of Amyotrophic Lateral Sclerosis
Authors: R H Brown
Journal: New England Journal of Medicine (1994)

Few diseases are as debilitating and inevitably lethal as amyotrophic lateral sclerosis (ALS). The disease typically strikes adults in midlife, causing paralysis and death within five years. The cause of most cases remains unknown, and the disease is untreatable. About 10 percent of patients have an inherited form of the disease. In 1993 a multicenter study reported that some cases of familial ALS arise because of mutations in the gene encoding the cytosolic form of the enzyme copper-zinc superoxide dismutase (SOD1).1 This enzyme detoxifies the superoxide anion, a ubiquitous byproduct of aerobic metabolism. As a free radical (free to diffuse . . .
An acne free naevus
Authors: M.B. Hodgins, W.J. Cunliffe
Journal: British Journal of Dermatology (1977)

Journal Article An acne free naevus Get access M.B. Hodgins, M.B. Hodgins Search for other works by this author on: Oxford Academic Google Scholar W.J. Cunliffe W.J. Cunliffe Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 97, Issue 5, 1 May 1977, Pages 580–581, https://doi.org/10.1111/j.1365-2133.1977.tb14142.x Published: 01 May 1977
Macroamylasemia
Authors: J. Edward Berk, Hirokuni Kizu, Peter Wilding, Ronald L. Searcy
Journal: New England Journal of Medicine (1967)

THE clinical conditions generally considered when serum amylase is found to be elevated are those that either increase the amount of amylase entering the plasma or alter renal function and thereby impair urinary excretion of the enzyme.1 In 1964 Wilding, Cooke and Nicholson2 demonstrated that elevated amylolytic activity could also result from the formation of an amylase-globulin complex that was too large to be readily excreted by the kidneys. This communication is concerned with observations made in 3 patients with persistent hyperamylasemia of previously unexplained cause. In each of these patients the major portion of the serum amylase was shown . . .
Characteristics of Adults in the Hepatitis B Research Network in North America Reflect Their Country of Origin and Hepatitis B Virus Genotype
Authors: Marc G. Ghany, Robert Perrillo, Ruosha Li, Steven H. Belle, Harry L.A. Janssen, Norah A. Terrault, Margaret C. Shuhart, Daryl T.-Y. Lau, W. Ray Kim, Michael W. Fried, Richard K. Sterling, Adrian M. Di Bisceglie, Steven-Huy B. Han, Lilia Milkova Ganova-Raeva, Kyong-Mi Chang, Anna Suk-Fong Lok, Raymond T. Chung, Lewis R. Roberts, Coleman I. Smith, Mauricio Lisker-Melman, David K. Wong, Joshua Juan, Jordan Feld, Colina Yim, Jenny Heathcoate, William M. Lee, Son Do, Tram T. Tran, Mandana Khalili, Stewart L. Cooper, Robert J. Fontana, Naoky Tsai, Keyur Patel, Donna Evon, Robert C. Carithers, Kris V. Kowdley, Chia C. Wang, T. Jake Liang, Jang-June Park, Abdus Wahed, David Kleiner, Nezam Afdhal, Asad Javaid, Jianghe Niu, Johanna Han, Imad Nasser, Alisha C. Stahler, Linda Stadheim, Mohamed Hassan, Debra L. King, Rosemary A. Nagy, Danie La, Lucie Liu, Stacey Minshall, Sheila Bass, Samuel French, Velma Peacock, Ashley Ungermann, Claudia Ayala, Emma Olson, Ivy Lau, Veronika Podolskaya, Nata DeVole, Barbara McKenna, Kelly Oberhelman, Sravanthi Kaza, Cassandra Rodd, Leslie Huddleston, Peter Poerzgen, Jama M. Darling, A. Sidney Barritt, Tiffany Marsh, Vikki Metheny, Danielle Cardona, Velimir A. Luketic, Paula G. Smith, Charlotte Hofmann, Terri Mathisen, Susan Strom, Jody Mooney, Lupita Cardona-Gonzalez, Nancy Fryzek, Elenita Rivera, Nevitt Morris, Vanessa Haynes-Williams, Mary E. Valiga, Keith Torrey, Danielle Levine, James Keith, Michael Betts, Luis J. Montaner, Chong-Gee Teo, Yury Khudyakov, Lili T. Punkova, Yona Cloonan, Michelle Danielson, Tamara Haller, Geoffrey Johnson, Stephanie Kelley, Sharon Lawlor, Ruosha Li, Manuel Lombardero, Joan M. MacGregor, Andrew Pelesko, Donna Stoliker, Barbara Walters, Ella Zadorozny
Journal: Clinical Gastroenterology and Hepatology (2014)
CHEMICAL, CLINICAL, AND IMMUNOLOGICAL STUDIES ON THE PRODUCTS OF HUMAN PLASMA FRACTIONATION. XI. THE USE OF CONCENTRATED NORMAL HUMAN SERUM GAMMA GLOBULIN (HUMAN IMMUNE SERUM GLOBULIN) IN THE PROPHYLAXIS AND TREATMENT OF MEASLES 12
Authors: J. Stokes, E. P. Maris, S. S. Gellis
Journal: Journal of Clinical Investigation (1944)

tion II, were used.Sufficient data for valid conclusions were obtained with Fraction II.With strict criteria of age, time of exposure, and amount of globulin, curves demonstrating the percentage of no measles of two age groups over a range of dosage were developed.The striking value of Fraction II of human globulin for protection against and attenuation of measles was evident.For size of dosage and ease of injec- tion, gamma globulin Fraction II surpasses other types of human immune bodies.B. TREATMENT
Two Cases of Valvular Thrombosis Secondary to Heparin-Induced Thrombocytopenia Managed Without Surgery
Authors: Sylvie Ricome, S. Provenchere, B. Aubier, N. Ajzenberg, L. Lepage, M.P. Dilly, G. Dufour, P. Montravers, D. Longrois
Journal: Circulation (2011)
Psychiatric morbidity in men one week after first acute myocardial infarction.
Authors: G G Lloyd, R H Cawley
Journal: BMJ (1978)

One week after a first myocardial infarction 35 out of 100 consecutive men patients aged under 65 were found by standardised clinical interview to have psychiatric morbidity. In 16 the morbidity had been evident before the infarct, and these patients showed a wider range of psychopathology than those whose symptoms had been precipitated by the infarct. The results suggest that psychiatric morbidity in patients with heart disease is not necessarily a result of the disease process. Thus characterising psychiatric morbidity and identifying the patients' individual needs are important if rehabilitation is to be effective.
Death Certificate Completion by Physicians-Reply
Authors: Steven D. Stellman
Journal: JAMA (1996)

<h3>In Reply.</h3> —We agree with Dr Hoffer that any properly trained physician should be able to complete a death certificate correctly, but our data demonstrate that "proper training" should be formalized within the medical school curriculum. There are many opportunities in the medical school setting in which death certification should be emphasized. These include teaching rounds, clinical pathology conferences, and, as Hoffer suggests, autopsy. Whenever a death is discussed in any of these settings, the appropriate completion of the death certificate for the case should be part of the discussion. We also endorse Dr Hanzlick's suggestions for measures to improve the ability of physicians to certify deaths correctly. If various licensing boards and other examinations include technical questions about certification procedures, physicians in training would have to acquire the skills needed to complete the certificate properly by reading and absorbing the available literature. However, rather than targeting physicians who might be more