CARBARSONE TOXICITY: A REVIEW OF THE LITERATURE AND REPORT OF 45 CASES
Authors: Ryle A. Radke, Waddy G. Baroody
Journal: Annals of Internal Medicine (1957)

Article1 September 1957CARBARSONE TOXICITY: A REVIEW OF THE LITERATURE AND REPORT OF 45 CASESRYLE A. RADKE, WADDY G. BAROODYRYLE A. RADKESearch for more papers by this author, WADDY G. BAROODYSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-47-3-418 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptInorganic arsenic has been employed empirically in therapeutics for centuries. Modern use of the drug dates from the researches of Paul Ehrlich into syphilotherapy, during which time he synthesized and tested the treponemicidal effect of organic arsenicals, including stovarsol and carbarsone. Marchoux1 demonstrated stovarsol to be amebicidal. Carbarsone (4-car-baminophenyl-arsonic acid) was shown to be amebicidal by Reed,2 since which time it has been employed extensively in antiamebic therapy. Reports of toxicity to this compound have been remarkably few, in sharp contrast to inorganic arsenic and the organic compounds formerly widely employed in syphilotherapy.In reviewing the literature of carbarsone toxicity...Bibliography1. Marchoux E: Action of Stovarsol on intestinal parasitism, Paris méd. 2: 421-426, 1924. Google Scholar2. Reed AC: Animal parasites of man and their control, Science 72: 611, 1930. CrossrefMedlineGoogle Scholar3. Smithies F, quoted in Council in Pharmacy and Chemistry, Carbarsone, J. A. M. A. 103: 258-259, 1934. Google Scholar4. Radke RA: Studies in chronic amebiasis. II. Evaluation of treatment technics, Gastroenterology 25: 1-10 (Sept.) 1953. CrossrefMedlineGoogle Scholar5. Von HagenCarlBrockman KONENW: Cerebral symptoms resulting from overdose of carbarsone, Bull. Los Angeles Neurol. Soc. 12: 148, 1947. MedlineGoogle Scholar6. AndersonReed HHAC: Untoward effects of antiamebic drugs, Am. J. Trop. Med. 14: 269, 1934. CrossrefGoogle Scholar7. Epstein E: Toxicity to carbarsone, J. A. M. A. 106: 769, 1936. CrossrefGoogle Scholar8. Nelson RS: Hepatitis due to carbarsone, J. A. M. A. 160: 764-766, 1956. MedlineGoogle Scholar9. HangerGutman FMAB: Post-arsphenamine jaundice apparently due to obstruction of intra-hepatic biliary tract, J. A. M. A. 115: 263, 1940. CrossrefGoogle Scholar10. CalamariGenn JAS: Personal communication. Google Scholar11. KrainerBlackMcGillRao LDARJNV: Report on investigation of arsenical encephalopathy in Indian troops from General Headquarters (India) Medical Research Organization, 1943-1945, Manager, Government of India Press, New Delhi, 1948. Google Scholar12. Radke RA: Hepatitis in the military situation, M. Bull. U. S. Army Far East 2: 7-11 (Jan.) 1954. MedlineGoogle Scholar13. AlbrightGordon ECES: Present status of the problem of amebiasis, Arch. Int. Med. 79: 253-271, 1947. CrossrefGoogle Scholar14. ElsomRogersWood KAAMFC: Amebiasis in an Army general hospital in India, Gastroenterology 8: 135, 1947. MedlineGoogle Scholar15. KnightTarun AADW: A search for liver damage in anti-amebic treatment with diodoquin, vioform and carbarsone, Am. J. Trop. Med. 1: 727, 1952. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: *Received for publication November 21, 1956.From the Department of Medicine, Fitzsimons Army Hospital, Denver, Colorado.Presented at the Northwest Regional Meeting of The American College of Physicians, November 16, 1956.Requests for reprints should be addressed to Colonel Ryle A. Radke, MC (Ret.), 3202 Colby Avenue, Everett, Washington. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byThe Treatment of Intestinal Protozoan InfectionsAntiprotozoicaAmoebiasisNERVOUS SYSTEM REACTIONS TO DRUGSEXPERIMENTAL TOXIC INJURY OF THE LIVERCLINICAL AND LABORATORY MANIFESTATIONS OF HEPATOTOXICITYIntrahepatic cholestasis following administration of chlorpropamideDRUG-INDUCED HEPATIC INJURY*HANS POPPER, M.D., F.A.C.P., FENTON SCHAFFNER, M.D., F.A.C.P. 1 September 1957Volume 47, Issue 3Page: 418-427KeywordsArsenicDiarrheaDrug synthesisDrugsHospital medicineNauseaPharmacologyResearch laboratoriesToxicityUnited States pharmacopeia ePublished: 1 December 2008 Issue Published: 1 September 1957 PDF downloadLoading ...