tbuckley/cabot-search huggingface dataset:
Current State of Clinical Translation of Cardioprotective Agents for Acute Myocardial Infarction
Authors: Robert A. Kloner
Journal: Circulation Research (2013)

There is continued interest in the concept of limiting myocardial infarct size with adjunctive agents administered along with reperfusion injury; however, there remains considerable controversy in the literature. The purpose of this article is to review the medical literature on clinical trials performed during the past 3 years that have attempted to reduce myocardial infarct size by administration of adjunctive therapies along with reperfusion therapy. A PubMed-driven literature search revealed a host of clinical trials focusing on the following prominent types of therapies: endogenous conditioning (postconditioning and remote ischemic conditioning); rapid cooling; pharmacological therapy (cyclosporine, abciximab, clopidogrel, tirofiban, erythropoietin, thrombus aspiration, adenosine, glucose–insulin–potassium, statins, antidiabetic agents, FX06, iron chelation, and ranolazine). Although there remains some controversy, quite a few of these studies showed that adjunctive therapy further reduced myocardial infarct size when coupled with reperfusion. Antiplatelet agents are emerging as some of the newest agents that seem to have cardioprotective capabilities. Postconditioning has become a bit more controversial in the clinical literature; remote conditioning, early and rapid cooling, adenosine, and ranolazine are intriguing therapies deserving of larger studies. Certain agents and maneuvers, such as erythropoietin, protein kinase C δ inhibitors, iron chelation, and intra-aortic balloon counterpulsation, perhaps should be retired. The correct adjunctive therapy administered along with reperfusion has the capability of further reducing myocardial injury during ST-segment–elevation myocardial infarction.
Bladder Carcinoma and Phenacetin
Authors: THOMAS E. BURKART
Journal: Annals of Internal Medicine (1980)

Letters and Corrections1 January 1980Bladder Carcinoma and PhenacetinTHOMAS E. BURKART, M.D.THOMAS E. BURKART, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-92-1-131_1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: Dr. Plotz and associates describe in the August 1979 issue (1) the possible complication of bladder carcinoma resulting from use of cyclophosphamide. They describe two patients; one a patient with rheumatoid arthritis, the other a patient treated for lupus erythematosus. They strongly suggest that the carcinomas detected in these patients after treatment were secondary to cyclophosphamide.I do not question their concerns; I do feel however, that their investigation of possible causes was inadequate. Use of analgesics as prescribed by physicians or taken independently by these patients was not described. It is becoming recognized that there are...References1. PLOTZKLIPPELDECKER PJJ. Bladder complications in patients receiving cyclophosphamide for systemic lupus erythematosus or rheumatoid arthritis. Ann Intern Med. 1979;91:221-3. LinkGoogle Scholar2. GONWABUCKALEWCORBETT TVW. Analgesic nephropathy and urinary-tract carcinoma. Ann Intern Med. 1979;90:432-3. Editorial. LinkGoogle Scholar1. BENGTSSONJOHANSSONANGERVALL USL. Malignancies of the urinary tract and their relation to analgesic abuse. Kidney Int. 1978;13:107-13. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Pitt Internal & Renal Medicine Associates, Ltd. Greenville, NC 27834 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 January 1980Volume 92, Issue 1Page: 131-131KeywordsAnalgesicsBladderCyclophosphamideLupus erythematosusPatientsRheumatoid arthritis Issue Published: 1 January 1980 PDF DownloadLoading ...
Identification of hBD-3 in respiratory tract and serum: the increase in pneumonia
Authors: H. Ishimoto, H. Mukae, Y. Date, T. Shimbara, M. S. Mondal, J. Ashitani, T. Hiratsuka, S. Kubo, S. Kohno, M. Nakazato
Journal: European Respiratory Journal (2006)

Human β-defensin (hBD)-3, a 45 amino acid antimicrobial peptide, was originally isolated from human skin. hBD-3 mRNA has also been detected in the airways by RT-PCR. While hBD-3 may be involved in antimicrobial defences within the respiratory tract, the presence of hBD-3 peptide in the respiratory system has not yet been confirmed. The antimicrobial activity of the synthesised hBD-3 peptide was measured by a radial diffusion assay and a colony count assay. The present authors confirmed the presence of hBD-3 peptide in homogenates of human lung and serum using reverse-phase HPLC coupled with a highly sensitive RIA. The localisation of the hBD-3 peptide was investigated by immunohistochemistry. In addition, the serum concentrations of hBD-3 were measured by RIA. hBD-3 exhibited a strong antimicrobial activity, which was unaffected by increasing salt concentrations. Immunohistochemically, the current authors observed the expression of hBD-3 in bronchial and bronchiolar epithelial cells. The mean± sd serum concentration of hBD-3 in patients with bacterial pneumonia was 239.4±17.8 pg·mL −1 in the acute phase and, decreased to 159.3±20.1 pg·mL −1 after the completion of therapy. In conclusion, these findings will help elucidate the role of human β-defensin-3 in host immune responses and identify the pathophysiological significance of this molecule in respiratory infections.
Psychotherapy in Torsion Dystonia
Authors: Leon Tec
Journal: JAMA (1970)

ABSTRACT To the Editor:— In response to the communication by Eldridge et al, The Limited Role of Psychotherapy in Torsion Dystonia (210:705, 1969), I was very pleased to see myself quoted.The psychiatrist, after one visit, advised that our son's problem was not psychological but related to the nervous control of muscles. His words at that time were If we work at it we could also make it a psychological problem...I believe it is of great importance for psychiatrists to be aware of dystonia because a great deal of time, effort, and misery is associated with the delayed diagnosis. For example, a 15-year-old boy was in psychotherapy because his symptoms were considered hysterical. Even after I saw him in consultation and made a diagnosis of torsion dystonia, the family was not convinced. My immediate referral to Dr. Cooper was not followed, instead they wanted an additional neurological examination. This
Prospective evaluation of gene mutations and minimal residual disease in patients with core binding factor acute myeloid leukemia
Authors: Eric Jourdan, Nicolas Boissel, Sylvie Chevret, Eric Delabesse, Aline Renneville, Pascale Cornillet, Odile Blanchet, Jean-Michel Cayuela, Christian Recher, Emmanuel Raffoux, Jacques Delaunay, Arnaud Pigneux, Claude-Eric Bulabois, Céline Berthon, Cécile Pautas, Norbert Vey, Bruno Lioure, Xavier Thomas, Isabelle Luquet, Christine Terré, Philippe Guardiola, Marie C. Béné, Claude Preudhomme, Norbert Ifrah, Hervé Dombret
Journal: Blood (2013)
Further Report ON THE TREATMENT OF PERNICIOUS ANAEMIA BY SALVARSAN AND NEO-SALVARSAN
Authors: B. Bramwell
Journal: BMJ (1915)

MA1ARCH 6, 19I5 406 application of a sufficiently strollg alltiseptic d10es, uder favouIiable conldition1s as to timIie and the nature of tlhe wvound, materially aid in destroyingF thle infection anid pre- ventinlg its spread, tlhCn it seem1s cIlear that suLichi an app'icaticn shiould be made in all suitable cascs.
Phaeochromocytoma presenting as an acute abdomen: report of two cases.
Authors: D J Jones, P Durning
Journal: BMJ (1985)

Phaeochromocytomas are catecholamine secreting tumours, usually arising in the adrenal medulla.The most common clinical manifestation is hypertension, although many symptoms and signs have been described.'Presentation as an acute abdominal emergency is rare.We describe two such cases, which presented within three weeks of each other to a district general hospital.Case 1 A 55 year old man presented having suddenly developed severe, constant left sided abdominal pain and vomiting three hours earlier.He appeared profoundly shocked, with a sinus tachycardia of 160 beats/min and a blood pressure of 160/110 mm Hg.There was a large, tender, ballotable left sided abdominal mass.Results of investigations were: haemoglobin concentration 145 g/l, white cell count 253x109/l, serum amylase activity 4310 IU/1, and glucose concentration 9 9 mmol/l (178 mg/100 ml).Urgent ultrasound scan showed a large retroperitoneal mass with solid and cystic areas.The spleen and left kidney could not be distinguished.Intravenous urography showed a normal but laterally displaced left kidney and renal tract.He continued to appear profoundly shocked, and we proceeded to laparotomy, suspecting massive intra-abdominal haemorrhage.In the operating room he developed severe pulmonary oedema soon after induction of anaesthesia.Laparotomy disclosed a huge left sided retroperitoneal mass containing a haematoma.The pancreas was entirely normal.Further surgery was abandoned owing to the patient's poor condition.Intermittent positive pressure ventilation was continued postoperatively.His tachycardia had persisted at 160/min and blood pressure was stable at 160/90 mm Hg.There was profound peripheral vasoconstriction, which was not relieved by an infusion of sodium nitroprusside.A phaeochromocytoma was suspected and blood samples taken for estimation of catecholamine values.The patient died before the response to ct and blockers could be tested.At necropsy a 22 cm diameter haemorrhagic phaeochromocytoma of the left adrenal was found, weighing 2180 g.Death was due to acute left ventricular failure.The plasma noradrenaline concentration immediately before death was 1150 nmol/l (195 0 ng/ml) (normal 1-6 nmol/l; 0 17- 1-02 ng/ml).Case 2 A 77 year old woman presented with an eight hour history of severe constant pain in the right hypochondrium, vomiting, and rigors.She also complained of attacks of palpitations for two years.On examination she was obviously in pain; she was sweating but had no fever, pulse was 1 10/min and irregular with multiple extrasystoles, and blood pressure was 150/90 mm Hg.There was guarding and tenderness with rebound in the right hypochondrium.Results of investigations were in keeping with a diagnosis of acute
Significant Head Motion Can Cause Either Hypermetabolic or Hypometabolic Cerebral Activity on 18F-FDG PET/CT
Authors: Linh Thuy Ho, Vincent Ngo, Harvard Vuu, Richard Montion
Journal: Clinical Nuclear Medicine (2012)

We report 2 separate cases with significant head motion causing apparent hypometabolic and hypermetabolic cerebral activity on FDG PET/CT. Case 1 is a 57-year-old man with facial numbness status post chemotherapy for mantle cell lymphoma. Restaging attenuation-corrected PET showed increased left frontal region activity, whereas nonattenuation-corrected PET demonstrated evidence of patient motion with normal physiologic left frontal cortical activity. Case 2 is a 78-year-old man with history of malignant melanoma. Attenuation-corrected PET/CT demonstrated diffusely decreased activity in the left cerebral hemisphere, whereas nonattenuation-corrected PET showed significant head motion with intact cortical activity.
Adolescents in Crisis: Evaluation of a Questionnaire
Authors: ALVIN YUSIN, RUTH SINAY, KAZUO NIHIRA
Journal: American Journal of Psychiatry (1972)

This paper presents data from a crisis evaluation questionnaire administered to 50 adolescents admitted to the Los Angeles County-University of Southern California Medical Center. Analysis of the questionnaire delineated four crisis behaviors—suicidal, aggressive, psychotic, and psychotic-drug—as the reasons for hospitalization. Each behavioral group was evaluated in terms of life situation areas covered by the questionnaire. Analysis of results identified characteristic life situations for each group, which could be used to differentiate the four groups.
Vincristine and Platelet Function-Reply
Authors: Thomas D. Stevenson
Journal: JAMA (1982)

<h3>In Reply.—</h3> Drs Steinherz and Miller have questioned our failure to consider vincristine as an antiplatelet agent and the statement in our recent article that the action of<i>Vinca</i>alkaloid on platelet function is unknown. They cite their publication<sup>1</sup>as evidence for the in vivo antiplatelet effect of vincristine, which they suggest accounts for the therapeutic effect in TTP observed by us. They described an inhibition of second-phase platelet aggregation to epinephrine and ADP, but found collagen-induced aggregation unimpaired, in a "large percentage" of children receiving multidrug therapy, including vincristine, for leukemia and solid tumors. In their patients with leukemia, platelet function was abnormal before administration of vincristine. We do not interpret these data as proof of a significant antiplatelet effect of vincristine. In their article in the<i>British Journal of Haematology</i>,<sup>1</sup>the authors cautiously stated on page 447 that "the findings seem to be related to the
Endoscopic Ultrasound Doppler Probes for Velocity Measurements in Vessels in the Upper Gastrointestinal Tract using a Multifrequency Pulsed Doppler Meter
Authors: K. Matre, S. Ødegaard, T. Hausken
Journal: Endoscopy (1990)

To quantify flow velocity in vascular structures in the upper gastrointestinal tract, prototype ultrasound Doppler transducers having frequencies of 5 and 10 MHz were designed. Connected to an advanced pulse ultrasound Doppler meter via an isolation transformer for patient safety, these transducers enabled the recording of flow velocity in vessels within an surrounding the wall of the GI tract. This set up improves the endoscopic ultrasound Doppler method by extending the measurable depth-range by using two frequencies, permitting independent selection of measuring depth and sample volume length, and giving an output format which includes full spectral analysis, simultaneous ECG and capabilities of displaying two additional signals.
Seroconversion ameliorates liver function in patients with chronic active hepatitis B (CAH-B): Results from a randomized, controlled trial
Authors: J. Reichen, P.J. Malé, S. Chevilli, J.J. Gonvers, J. Altorfer, H. Biihler, D. Lavanchy, P.C. Frey
Journal: Journal of Hepatology (1990)
Waldenström's Macroglobulinemia
Authors: James W. Hampton
Journal: New England Journal of Medicine (1958)

IN 1944 Waldenström1 described a clinical syndrome characterized by a hemorrhagic diathesis, leukopenia and the presence of an abnormal protein of large molecular weight. He entitled the syndrome "incipient myelomatosis." Since his original description many studies have been concerned with the presence, chemical characteristics and implications of abnormal serum proteins in a variety of disorders. Particular interest has been attracted to the abnormal proteins observed during the course of multiple myeloma,2 leukemia, lymphomas and liver diseases. In the American literature, however, only a few cases have been reported that fit the syndrome now known as macroglobulinemia of Waldenström. The problem . . .
Authors' Response to Gowdy
Authors: Atle Fretheim, Andrew D Oxman
Journal: PLoS Medicine (2006)

Because of the nature of the analysis used in this study [1], no conclusion is possible.There are plenty of examples in the literature demonstrating the "ecological fallacy".Studies such as this have very little utility other than to generate hypotheses.I tend to think that this association is a marker for greater recognition and treatment for depression.However, it's a brave epidemiologist who would draw any conclusions at all from an ecological association such as this where the outcome is relatively rare.
Erythropoietin-dependent transformation of myelodysplastic syndrome to acute monoblastic leukemia
Authors: Udomsak Bunworasate, Hilal Arnouk, Hans Minderman, Kieran L. O'Loughlin, Sheila N. J. Sait, Maurice Barcos, Carleton C. Stewart, Maria R. Baer
Journal: Blood (2001)
Association Between &lt;EMPH TYPE="ITAL"&gt;BRCA1&lt;/EMPH&gt; Mutations and Ratio of Female to Male Births in Offspring of Families With Breast Cancer, Ovarian Cancer, or Both
Authors: Miguel de la Hoya
Journal: JAMA (2003)

Defects in X-chromosome inactivation distort sex ratio in mice. The BRCA1 gene is also involved in X-chromosome inactivation, suggesting the possibility that some sex-ratio distortion may be associated with BRCA1-related human cancer syndromes.To determine whether BRCA1 mutations are associated with distortion of the sex ratio of births in families with breast cancer, ovarian cancer, or both.Analysis of germline mutations in participants from Spain who had been screened for BRCA between 1998 and 2002.Sixty-eight families with at least 3 breast cancer cases or ovarian cancer cases, or both types of cancer in 2 generations (germline mutations: BRCA1, n = 17; BRCA2, n = 15; and BRCA unrelated, n = 36). An average of 4 relatives per family were tested for the corresponding BRCA mutation.Male and female births registered in breast and/or ovarian pedigrees tested for the presence of BRCA1 and BRCA2 germline mutations.Of BRCA1-related breast and/or ovarian cancer pedigrees, there was a 2-fold excess of female births (218 female vs 109 male births). Of BRCA2-related or BRCA-unrelated breast and/or ovarian cancer pedigrees, there was not an excess of female births (175 female/150 male and 344 female/315 male, respectively). Of 327 BRCA1 births, 218 (67%) were female births compared with 54% among BRCA2 pedigrees (175/327; P<.001) and 52% among BRCA-unrelated pedigrees (344/659; P<.001). Female births increased in the offspring of BRCA1 carriers compared with BRCA2 carriers (67% vs 52%; P =.004).In these families with breast and/or ovarian cancer, mutations in BRCA1 but not BRCA2 were associated with a sex ratio skewed against male births.
Immunotherapy with oligomannose‐coated liposomes ameliorates allergic symptoms in a murine food allergy model
Authors: Akiko Kawakita, Hisako Shirasaki, Motoko Yasutomi, Shuko Tokuriki, Mitsufumi Mayumi, Hironobu Naiki, Yusei Ohshima
Journal: Allergy (2012)

Abstract Background: Allergen‐specific immunotherapy has been anticipated to be a disease‐modifying therapy for food allergies. We previously reported that CD 8 + regulatory T cells may prevent antigen‐sensitized mice from developing allergic diarrhea. Because oligomannose‐coated liposomes ( OML ) have been shown to induce MHC class I ‐restricted CD 8 + T cell responses, we analyzed the adjuvant activities of OML for inducing regulatory CD 8 + T cells and mucosal tolerogenic responses in allergen‐sensitized mice. Methods: The BALB /c mice that were previously sensitized to ovalbumin ( OVA ) were intranasally immunized with OVA ‐encased in OML ( OVA ‐ OML ) or OVA ‐encased in non‐coated liposomes ( OVA ‐ NL ). We assessed allergic diarrhea induced by oral OVA administration, OVA ‐specific immunoglobulin production, and cytokine production in the intestines and mesenteric lymph nodes ( MLN s). Results: Intranasal immunization with OVA ‐ OML , but not OVA ‐ NL , suppressed the development of allergic diarrhea. This was associated with in vitro A g‐induced IL ‐10 production and the in vivo expansion of CD 8 + CD 28 − and CD 4 + CD 25 + F oxp3 + T cell populations among mesenteric lymph node mononuclear cells, and was significantly ablated by anti‐ SIGNR 1 or anti‐ CR 3 m A bs. Up‐regulation of serum OVA ‐specific I g E was suppressed, whereas OVA ‐specific I g G 1, I g G 2a, and soluble I g A production were enhanced by intranasal administration of OVA ‐ OML . Adoptive transfer of CD 8 + CD 28 − T cells but not CD 28 + CD 8 + T cells from the MLN s of OVA ‐ OML ‐treated mice ameliorated the development of diarrhea. Conclusion: These results suggest that intranasal immunization with A g‐encased OML may be an effective immunotherapy for food allergies, as it induces a subset of regulatory CD 8 + T cells as well as CD 4 + CD 25 + F oxp3 + T cell and modulates humoral immune responses in allergen‐sensitized mice.
THE COMBINATION OF SEATTLE HEART FAILURE MODEL AND SIX-MINUTE WALK TEST ELEVATES THE POWER TO IDENTIFY PATIENTS WITH CHRONIC HEART FAILURE AT HIGH RISK FOR CARDIAC DEATH: A 10-YEAR FOLLOW UP STUDY
Authors: Takahisa Yamada, Yuji Okuyama, Takashi Morita, Yoshio Furukawa, Koji Tanaka, Yusuke Iwasaki, Hiromichi Ueda, Takeshi Okada, Masato Kawasaki, Yuki Kuramoto, Hisashi Naito, Tadao Fujimoto, Masatake Fukunami
Journal: Journal of the American College of Cardiology (2011)
Generalized trichorrhexis nodosa
Authors: J.N. LEONARD, C.L. GUMMER, R.P.R. DAWBER
Journal: British Journal of Dermatology (1980)

A case of generalized trichorrhexis nodosa is described in a man. Electron histochemical studies showed abnormal staining consistent with a definite disorder in the formation of alpha-keratin chains within the globular matrix of the hair cortex with respect to cystine; keratin amino-acid analysis also revealed low cystine. This cortical change, together with multiple vacuoles found in the endocuticle, are evidently the intrinsic defeas which allow relatively trivial chemical and physical trauma to cause trichorrhexis nodosa.
Lung Perfusion Imaging in Tricuspid Atresia After Glenn and Fontan Repair
Authors: MAX A. STEVENS, BRADLEY J. KLEINSASSER, DENNIS J. CAVANAUGH, AIMEE S. BISH
Journal: Clinical Nuclear Medicine (1995)

A 21-year-old man with a history of tricuspid atresia was referred for ventilation perfusion lung imaging because of shortness of breath and hypoxia. He had a Blalock-Taussig shunt, a Waterston-Cooley shunt, a standard Glenn, and a Fontan procedure. A chest radiograph showed cardiomegaly and bilateral pleural effusions. The initial perfusion scan was performed with Tc-99m MAA injected through the right antecubltal vein. Activity was seen in the right lung only. A foot injection showed perfusion to the left upper lung only. Without previous knowledge of surgical intervention, a separate injection would not have been performed and the size of the defect would not have been accurately determined.
Utility of the Radioimmunoassay of Serum Thyrotrophin in Man
Authors: JEROME M. HERSHMAN
Journal: Annals of Internal Medicine (1971)

The normal human serum thyrotrophin (TSH) measured by a double antibody radioimmunoassay was 3.9 ± 2.0 (SD) µunits/ml. It was markedly elevated in 61 patients with primary hypothyroidism and undetectable in 10 with hypothyroidism secondary to hypopituitarism and in 23 hyperthyroid patients. There was no significant diurnal variation of serum TSH and no increase after cold exposure of adult men for 1 hr or after electroconvulsive, vasopressin, or glucagon therapy. The level was normal in patients with Cushing's syndrome and acromegaly and in pregnant women at term. The serum TSH of newborns exceeded the maternal level significantly and rose to very high values at 1 hr of age. Because of the stability of serum TSH levels in adults, an elevated level is good indication of primary hypothyroidism. Injection of synthetic thyrotrophin-releasing factor (500 to 1,000 µg) caused marked elevation of serum TSH; the response to 10 mg given orally was more prolonged. Synthetic thyrotrophin-releasing factor should be a useful agent for clinical assessment of pituitary TSH reserve.