EXPERIMENTAL STUDIES ON HEPARIN AND ITS INFLUENCE ON TOXICITY OF DIGITALOIDS, CONGO RED, COBRA VENOM AND OTHER DRUGS
Authors: David I. Macht
Journal: Annals of Internal Medicine (1943)

Article1 May 1943EXPERIMENTAL STUDIES ON HEPARIN AND ITS INFLUENCE ON TOXICITY OF DIGITALOIDS, CONGO RED, COBRA VENOM AND OTHER DRUGSDAVID I. MACHT, M.D., F.A.C.P.DAVID I. MACHT, M.D., F.A.C.P.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-18-5-772 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptINTRODUCTIONAt first engaging the attention primarily of physiologists and hematologists, the study1, 2, 3of heparin was soon taken up also by biochemists, who of recent years have succeeded largely in unraveling its complicated chemical structure. More recently, heparin has acquired a practical significance through the work of clinical investigators who discerned its potentialities as a therapeutic agent. Indeed, Howell and McDonald4had suggested such clinical applications of heparin, but its actual value in medical practice was not demonstrated until the painstaking investigations of American, Canadian and Swedish scientists were well under way. It is far beyond the scope...Bibliography1. MCLEAN J: The thromboplastic action of cephalin, Am. Jr. Physiol., 1916, xli, 250-257. CrossrefGoogle Scholar2. HOWELL WH: The coagulation of blood, Harvey Lectures, 1916-1917 volume, Series XII, 272-323. Google Scholar3. HOWELLHOLT WHE: Two new factors in blood coagulation, heparin and thrombosis, Am. Jr. Physiol., 1918, xlvii, 328-341. CrossrefGoogle Scholar4. HOWELLMCDONALD WHCH: Note on effect of repeated intravascular injections of heparin, Bull. Johns Hopkins Hosp., 1930, xlvi, 365-368. Google Scholar5. JORPES JE: Heparin, its chemistry, physiology and application in medicine, 1939, Oxford University Press, London. Google Scholar6. 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To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Baltimore, Maryland*Received for publication December 22, 1942.Read before the Section on Pathology and Physiology of the American Medical Association at Atlantic City, June 11, 1942.†Director, Pharmacological Research Laboratory, Hynson, Westcott & Dunning, Inc., Baltimore, Maryland. 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