Free-Base Cocaine Use Associated with Bronchiolitis Obliterans Organizing Pneumonia
Authors: RAJESH C. PATEL
Journal: Annals of Internal Medicine (1987)

Brief Reports1 August 1987Free-Base Cocaine Use Associated with Bronchiolitis Obliterans Organizing PneumoniaRAJESH C. PATEL, M.D., DEEPA DUTTA, M.D., STEVEN A. SCHONFELD, M.D.RAJESH C. PATEL, M.D.Search for more papers by this author, DEEPA DUTTA, M.D.Search for more papers by this author, STEVEN A. SCHONFELD, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-107-2-186 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptCocaine abuse is reaching epidemic proportions and its adverse health consequences are widespread (1). Although physiologic derangements have been shown in users of cocaine in "free-base" form (2, 3), to the best of our knowledge this case report is the first clinical and pathologic description of pulmonary toxicity associated with the use of free-base cocaine manifested as bronchiolitis obliterans organizing pneumonia.A previously healthy 32-year-old man with a 10-day history of nonproductive cough, fever, and dyspnea unresponsive to tetracycline and antitussives was hospitalized. He denied toxic exposures, homosexuality, or travel. He smoked a half pack of cigarettes per day for...References1. National surveillance of cocaine use and related health consequences. MMWR. 1982;31:265-73. MedlineGoogle Scholar2. WEISS R, GOLDENHEIM P, MIRIN S, HALES C, and MENDELSON J. Pulmonary dysfunction in cocaine smokers. Am J Psychiatry. 1981;138:1110-12. CrossrefMedlineGoogle Scholar3. ITKONEN J, SCHNOLL S, and GLASSROTH J. Pulmonary dysfunction in 'free-base' cocaine users. Arch Intern Med. 1984;144:2195-7. CrossrefMedlineGoogle Scholar4. LANGE W. Ueber eine eigenthumliche ErkrangKung der kleinen Bronchien und Bronchiolen. Dtsch Arch Klin Med. 1901;70:342-64. Google Scholar5. EPLER G, COLBY T, MCLOUD T, CARRINGTON C, and GAENSLER E. Bronchiolitis obliterans organizing pneumonia. N Engl J Med. 1985;312:152-8. CrossrefMedlineGoogle Scholar6. GOSINK B, FRIEDMAN P, and LEIBOW A. Bronchiolitis obliterans: roentgenologic-pathologic correlation. Am J Roentgenol Radium Ther Nucl Med. 1973;117:816-32. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: RAJESH C. PATEL, M.D.; DEEPA DUTTA, M.D.; STEVEN A. SCHONFELD, M.D.Affiliations: Sinai Hospital of Baltimore Baltimore, Maryland PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byRepublication de : Complications pulmonaires chez les consommateurs de cocaïneComplications pulmonaires chez les consommateurs de cocaïnePneumomédiastin et consommation de cocaïnePneumomédiastin en rapport avec la consommation de cocaïne : à propos d’un casPulmonary Effects of Cocaine UsePneumomédiastin et consommation de cocaïneCocaineHigh-Resolution Computed Tomographic Findings of Cocaine-Induced Pulmonary Disease: A State of the Art ReviewStimulants and the LungCocainePathologies respiratoires aiguës et subaiguës d’origine toxiqueCocaineForensic Lung PathologyImmunologic Lung Disease in the Critically IllLung DiseasePulmonary Complications from Cocaine and Cocaine-based Substances: Imaging ManifestationsPulmonary Complications of Illicit Drug UseAn overview of non-cardiac cocaine toxicityCocainePathology of Drug Abuse«Pulmón de crack»The pulmonary pathology of illicit drug and substance abusePulmonary effects of illicit drug useDrug-induced bronchiolitis obliterans organizing pneumoniaPulmonary alterations in cocaine usersThe pathophysiology of cocaine abuseLe bonheur est dans le préEvidence of Chronic Damage to the Pulmonary Microcirculation in Habitual Users of Alkaloidal (“Crack”) CocaineAirway effects of marijuana, cocaine, and other inhaled illicit agentsRecreational Drug Abuse and AsthmaThe role of recreational drugs in traumaDrug-Induced Respiratory DisordersCorticosteroids in Acute Respiratory FailureAnaesthetic implications of drug abuse in trauma patientsRECREATIONAL DRUGSPrinciples of management of the poisoned patientBronchiolitis Obliterans With Organizing Pneumonia and Cold Agglutinin Disease Associated With Phenytoin Hypersensitivity SyndromeCocaine: Pathophysiology and clinical toxicologyRespiratory toxicities from stimulant useEffects of ‘Crack’ Cocaine on Pulmonary Alveolar PermeabilityBronchiolitis obliterans in a patient with HIV infectionCyclophosphamide in severe steroid-resistant bronchiolitis obliterans organizing pneumoniaHIV IN ILLICIT DRUG USERSLung disease induced by drug addiction.Stimulant-Induced Pulmonary ToxicityBronchiolitis obliterans with organising pneumonia: outcome.Bronchiolitis obliterans organising pneumonia: a clinical and radiological reviewThe Pulmonary Complications of Crack CocaineTres formas no idiopáticas de bronquiolitis obliterante con neumonía en organizaciónCRYPTOGENIC ORGANIZING PNEUMONITISBronchiolitis Obliterans Organizing Pneumonia Caused by Plasmodium vivax MalariaRespiratory failure and eosinophilia in a young manCocaine: Medical ToxicityBronchiolitis Obliterans Organizing Pneumonia Associated with Systemic Lupus ErythematosusSmoked Cocaine: Patterns of Use and Pulmonary ConsequencesDrug-induced Pulmonary DiseaseBOOP in EuropeBronchiolitis Obliterans Organizing Pneumonia: Definition and Clinical FeaturesPulmonary Complications from Alveolar Accumulation of Carbonaceous Material in a Cocaine SmokerAcute Treatment of Alcohol and Cocaine EmergenciesRespiratory Complications of Cocaine AbusePulmonary Status of Habitual Cocaine SmokersInterstitial Pneumonitis Associated with “Crack” Cocaine AbuseIncreased Lung Permeability following Long-term Use of Free-base Cocaine (Crack)BOOP and COP.Barotrauma related to inhalational drug abusePulmonary Reactions from Illicit Substance AbuseA review of the respiratory effects of smoking cocainePulmonary Artery Medial Hypertrophy in Cocaine Users without Foreign Particle MicroembolizationIdiopathic Bronchiolitis Obliterans Organizing PneumoniaCocaine abuse: Historical, epidemiological, and clinical perspectives for pediatriciansBronchiolitis obliterans organising pneumonia in patients taking acebutolol or amiodarone.Bronchiolitis Obliterans and Airways Obstruction Associated with Graft-versus-Host DiseaseApproach to the Patient with Diffuse Lung Disease 1 August 1987Volume 107, Issue 2 Page: 186-187 Keywords Bronchiolitis Cocaine Dyspnea Fevers Homosexuality Pneumonia Respiratory physiology Tetracyclines Toxicity ePublished: 1 December 2008 Issue Published: 1 August 1987 PDF downloadLoading ...