CHRONIC LIVER DISEASE FOLLOWING INFECTIOUS HEPATITIS. II. CIRRHOSIS OF THE LIVER
Authors: Henry G. Kunkel, Daniel H. Labby
Journal: Annals of Internal Medicine (1950)

Article1 March 1950CHRONIC LIVER DISEASE FOLLOWING INFECTIOUS HEPATITIS. II. CIRRHOSIS OF THE LIVERHENRY G. KUNKEL, M.D., DANIEL H. LABBY, M.D.HENRY G. KUNKEL, M.D.Search for more papers by this author, DANIEL H. LABBY, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-32-3-433 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe relationship of acute infectious hepatitis to cirrhosis has become the subject of considerable discussion at the present time. Most investigators favor the view that cirrhosis may occasionally develop from infectious hepatitis. A lesion resembling the toxic or post-necrotic cirrhosis originally described by Mallory1has been recorded by several observers.2-5A characteristic feature of this type of "cirrhosis" is a coarsely nodular hyperplasia of liver cells. This picture is very different from the finely nodular liver seen in Laennec's cirrhosis. Lucké6has maintained that the apparent increase in fibrous tissue is really due to a compression of the reticulum fibers...Bibliography1. Mallory FB: Cirrhosis of the liver. Five different types of lesion from which it may arise, Bull. Johns Hopkins Hosp. 22: 69-75, 1911. Google Scholar2. Bergstrand H: Ueber die akute und chronische gelbe Leberatrophie. Mit besonderer Berücksichtigung ihres epidemischen Auftretens im Schweden im Jahre, 1927, 1930, Georg Thiem, Leipzig. Google Scholar3. JonesMinot CMGR: Infectious (catarrhal) jaundice. An attempt to establish a clinical entity, Boston M. and S. J. 189: 531-551, 1923. CrossrefGoogle Scholar4. Cullinan ER: Idiopathic jaundice (often recurrent) associated with subacute necrosis of the liver, St. Bartholomew's Hosp. Rep. 69: 55-142, 1936. Google Scholar5. PrattStengel JHA: Toxic cirrhosis resulting from acute liver atrophy, Am. J. M. Sc. 173: 1-11, 1927. CrossrefGoogle Scholar6. Lucké B: The pathology of fatal epidemic hepatitis, Am. J. Path. 20: 471-593, 1944. MedlineGoogle Scholar7. WatsonHoffbauer CJFW: The problem of prolonged hepatitis with particular reference to the cholangiolitic type and to the development of cholangiolitic cirrhosis of the liver, Ann. Int. Med. 25: 195-227, 1946. LinkGoogle Scholar8. Sherlock S: Post-hepatitis cirrhosis, Lancet 254: 817-822, 1948. CrossrefGoogle Scholar9. Eppinger H: Die Leberkrankheiten. Allgemeine und spezielle Pathologie und Therapie der Leber, 1937, Julius Springer, Wien. Google Scholar10. KrarupRoholm NBK: Development of cirrhosis of the liver after acute hepatitis elucidated by aspiration biopsy, Acta med. Scandinav. 108: 306-331, 1941. CrossrefGoogle Scholar11. AxenfeldBrass HK: Klinische und bioptische Untersuchungen über den sogenannten Ikterus catarrhalis, Frankf. Ztschr. f. Path. 57: 147-236, 1942. Google Scholar12. Rennie JB: Infective hepatitis, with special reference to prognosis, Am. J. M. Sc. 210: 18-29, 1945. CrossrefGoogle Scholar13. DibleMcMichaelSherlock JHJSP: Pathology of acute hepatitis: Aspiration biopsy studies of epidemic, arsenotherapy, and serum jaundice, Lancet 2: 402-408, 1943. CrossrefGoogle Scholar14. KunkelLabbyHoagland HGDHCL: Chronic liver disease following infectious hepatitis. I. Abnormal convalescence from initial attack, Ann. Int. Med. 27: 202-219, 1947. LinkGoogle Scholar15. BarkerCappsAllen MHRBRB: Chronic hepatitis in the Mediterranean theater, J. A. M. A. 129: 653-659, 1945. CrossrefGoogle Scholar16. Kunkel HG: Value and limitations of the thymol turbidity test as an index of liver disease, Am. J. Med. 4: 201-207, 1948. CrossrefMedlineGoogle Scholar17. LabbyShankKunkelHoagland DHREHGCL: Intravenous therapy of cirrhosis of the liver, J. A. M. A. 133: 1181-1190, 1947. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: *Received for publication October 25, 1948.From the Hospital of The Rockefeller Institute for Medical Research. 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