tbuckley/cabot-search huggingface dataset:
Study of the effect of lactational bone loss on blood lead concentrations in humans.
Authors: J D Osterloh, T J Kelly
Journal: Environmental Health Perspectives (1999)

Lactation and other clinical states of high bone turnover have been suggested to release lead (Pb) stored in bone into blood and tissues. Previous observations on the influences of lactation have been anecdotal, or at high blood Pb concentrations with varying past exposures, or complicated by postpartum fluid changes. A prospective observational study was performed to investigate possible changes in blood lead concentrations at multiple intervals during lactation for 6 months postpartum and to relate changes in blood lead concentrations to changes in bone density and other variables. Volunteer pregnant subjects (n = 58) were enrolled from a midwifery service at an academic public health hospital. Subjects were mostly Hispanic, recently immigrated, of low economic status, not receiving supplemental calcium, and had low blood Pb concentrations (2.35 +/- 2.05 microg/dl at enrollment). Bone density losses over 6 months for the group averaged -2.46 +/- 6.33% at the vertebral spine and -0.67 +/- 5.21% at the femoral neck. In predicting final bone density, apart from initial bone density only the total number of breast-feedings was a significant independent variable of the variables tested, accounting for an additional 12% of the variability. No changes in blood Pb concentrations were seen over the interval beyond 2 weeks postpartum (minimum detectable change was 0.4 microg/dl). There was no relation between the changes in bone density and changes in blood Pb or the integrated blood Pb over the 2-week to 6-month period. Normal (nonlactating) bone resorption rates contribute a large fraction of the Pb in blood during low-exposure circumstances. However, during lactation the increase in bone resorptive processes is probably relatively small with a larger decrease in deposition accounting for net bone loss, as suggested by other investigations. Thus, concomitant release of Pb from bones of lactating subjects with low blood lead concentrations on this background of high normal resorption was not large enough for detection.
Restricted immunoglobulin variable region gene usage by normal Ly-1 (CD5+) B cells that recognize phosphatidyl choline.
Authors: T J Mercolino, A L Locke, A Afshari, D Sasser, W W Travis, L W Arnold, G Haughton
Journal: The Journal of Experimental Medicine (1989)

5-15% of lymphocytes in the peritoneums of normal adult B10.H-2aH-4bp/Wts (2a4b) mice are CD5+ (Ly-1) B cells that recognize phosphatidyl choline (PtC), a phospholipid component of all mammalian cells. We produced a set of IgM-secreting hybridomas from the peritoneal cells of normal, adult 2a4b mice. We found that this set of hybridomas shows a similarly high frequency of antibodies specific for PtC (21 of 86) that also react with bromelain-treated mouse erythrocytes. Restriction fragment analysis of Ig gene rearrangements and analysis of expressed Ig idiotypes reveal that these cells use a restricted set of variable region genes to generate the PtC-specific antibodies. The Ig genes used by the PtC-specific hybridomas appear to be the same as those found in the PtC-specific Ly-1 B cell lymphomas, CH27 and CH34.
Drought in the Southeast: Lessons for Water Management
Authors: John Manuel
Journal: Environmental Health Perspectives (2008)

Prolonged drought has shut down recreational activity at Lake Allatoona in Acworth, Georgia, as shown in this 2 November 2007 photo. DroughtSoutheast inthe Lessons for Water Management L ong spared the persistent droughts that have plagued the western United States this century, the Southeast suddenly finds itself the most rain-starved region of the country.In the face of this threat, policy makers and utility companies are struggling to identify sensible, sustainable options for managing the region's water.Although there currently is no immediate public health threat posed by the Southeastern drought, it does point to a very real situation in regions around the world that struggle to maintain an adequate supply of potable water.According to the Intergovernmental Panel on Climate Change report Climate Change 2007: The Physical Science Basis, as global temperatures increase due to rising atmospheric concentrations of carbon dioxide, so does evaporation.That, combined with cyclical drought, could pose dire threats to water supplies.By one model, published in volume 78, issue 5 (2006) of the Journal of Hydrometeorology, if global warming-related precipitation changes continue apace, the percentage of the Earth's surface in severe drought could rise from the current 3% to 30% by 2100.The Southeastern drought has already had serious economic consequences, according to the National Drought Mitigation Center at the University of Nebraska, which estimates in its Winter 2008 DroughtScape newsletter that 2007 losses to major field crops including corn, wheat, soybeans, cotton, and hay totaled more than $1.3 billion.Cattle farmers, nursery and landscape businesses, and recreation and tourism also have been hard hit.Low lake levels have forced power companies such as the Tennessee Valley Authority (TVA) and Duke Energy in North Carolina to reduce electricity generation from cheap, renewable hydropower and substitute more expensive and polluting fossil fuels.By the same token, if cooling reservoir levels were to fall far enough, it could force the shutdown of nuclear power plants.
UVR radiometry of solar simulated radiation in experimental photocarcinogenesis studies
Authors: A.R. YOUNG, A.V.J. CHALLONER, I.A. MAGNUS, A. DAVIS
Journal: British Journal of Dermatology (1982)

Journal Article UVR radiometry of solar simulated radiation in experimental photocarcinogenesis studies Get access A.R. YOUNG, A.R. YOUNG Department of Photobiology, Institute of Dermatology, Homerton Grove, London E9 6BX Search for other works by this author on: Oxford Academic Google Scholar A.V.J. CHALLONER, A.V.J. CHALLONER Department of Photobiology, Institute of Dermatology, Homerton Grove, London E9 6BX Search for other works by this author on: Oxford Academic Google Scholar I.A. MAGNUS, I.A. MAGNUS Department of Photobiology, Institute of Dermatology, Homerton Grove, London E9 6BX Search for other works by this author on: Oxford Academic Google Scholar A. DAVIS A. DAVIS Propellants, Explosives and Rocket Motor Establishment, Powdermill Lane, Waltham Abbey, Essex EN9 1BP Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 106, Issue 1, 1 January 1982, Pages 43–52, https://doi.org/10.1111/j.1365-2133.1982.tb00900.x Published: 01 January 1982 Article history Accepted: 23 March 1981 Published: 01 January 1982
Endoscopic retrograde cholangiopancreatography through a gastric stoma using an ultrathin endoscope: a novel approach
Authors: A. Mori, N. Ohashi, T. Maruyama, H. Tatebe, K. Sakai, H. Inoue, S. Takegoshi, M. Okuno
Journal: Endoscopy (2007)

Because a transoral or transnasal approach is essential to the performance of endoscopic retrograde cholangiopancreatography (ERCP) [1], difficulties are often encountered in complicated cases when either approach is problematic, including in patients who have suffered a cerebrovascular accident. In such patients percutaneous endoscopic gastrostomy (PEG) has often previously been carried out for long-term nutritional management. Here we describe the successful performance of ERCP through the gastric stoma using an ultrathin forward-viewing endoscope (EG530N5; Fujinon-Toshiba, Tokyo, Japan).
The Meaning of Brain Death
Authors: Robert D. Truog, Franklin G. Miller
Journal: JAMA Internal Medicine (2014)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Internal Medicine HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Internal Medicine journal
SELECTION OF BREAST-CANCER PATIENTS FOR ADRENALECTOMY AND HYPOPHYSECTOMY
Authors: H.J.B. Atkins, R.D. Bulbrook, M.A. Falconer, F.C. Greenwood, J.L. Hayward, K.S. Maclean, P. Schurr, P. Armitage
Journal: The Lancet (1960)
Abstract 1371: Histone lysine trimethylation or acetylation in sporadic breast tumor and matched normal tissue
Authors: Dominique J. Gallon-Bernard, Gaëlle Judes, Aslihan Dagdemir, Maureen Echegut, Seher Karsli-Ceppioglu, Marjolaine Ngollo, Andre Lebert, Frederique Penault-Llorca, Yves-Jean Bignon
Journal: Cancer Research (2014)

Abstract Breast cancer is responsible of cancer mortality in women worldwide. The challenge in carcinogenesis is to predict tumor progression. Epigenetics open new perspectives in this field. It was demonstrated that epigenetic alterations are involved in cancer. DNA methylation or histone modifications can regulate gene transcription. Our goal was to determine the role of different histone marks, such as H3K27me3, H3K4ac and H3K9ac on the expression of a panel of genes involved in breast cancer: BRCA1, ERβ, EZH2, P300, SRC3, ERα and PGR. For this study, we used less than one hundred sporadic breast tumors and matched normal tissues. We performed chromatin immunoprecipitation and Q-PCR. After that, we checked the gene expression assaying RNA with RT-QPCR and proteins with Western blotting. Finally, we demonstrated that H3K4ac marks behaved like H3K27me3 repressive marks. The increase of H3K9ac marks resulted in the overexpression of ERα and P300 genes in the tumors. For the underexpressed genes BRCA1 and ERβ, we found that their repression did not pass through the repressive marks H3K27me3 nor H3K4ac but by other mechanisms perhaps DNA methylation. Then, we used variance analysis and studied interactions between the studied different marks and intrinsic subtypes of breast cancer according to St Gallen International Expert Consensus. Finally, we defined gene-mark couples in each subtypes. At the end, a decision tree was drawn and determined 4 genes (BRCA1, ERα, ERβ, and PGR) and 2 marks (H3K27me3 and H3K4ac) that separated subtypes in the present study. Citation Format: Dominique J. Gallon-Bernard, Gaëlle Judes, Aslihan Dagdemir, Maureen Echegut, Seher Karsli-Ceppioglu, Marjolaine Ngollo, Andre Lebert, Frederique Penault-Llorca, Yves-Jean Bignon. Histone lysine trimethylation or acetylation in sporadic breast tumor and matched normal tissue. [abstract]. In: Proceedings of the 105th Annual Meeting of the American Association for Cancer Research; 2014 Apr 5-9; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2014;74(19 Suppl):Abstract nr 1371. doi:10.1158/1538-7445.AM2014-1371
The Contribution of Psychiatry to Medical Practice
Authors: Robert W. Hyde
Journal: New England Journal of Medicine (1952)

I APPROACH my topic not from an objective point of view but subjectively, and by asking myself the following personal question: What have I learned in psychiatry that would have been useful had I known it in my five years of general practice in rural Vermont? Even here I could far more easily have spoken on the subject of what my medical practice has contributed to my knowledge of psychiatry. With this explanation I make a presentation that is predominantly anecdotal rather than the scientific document that might have been expected.In the diagnosis of the conventional psychiatric disorders that . . .
Thirty-Year Follow-up of an African American Family with Macular Dystrophy of the Retina, Locus 1 (North Carolina Macular Dystrophy)
Authors: Daniel F. Kiernan, Rohan J. Shah, Seenu M. Hariprasad, Michael A. Grassi, Kent W. Small, Joseph P. Kiernan, William F. Mieler
Journal: Ophthalmology (2011)
Mental Health Agenda Now Set for US Children
Authors: Mike Mitka
Journal: JAMA (2001)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
<i>Journal</i>Ventures That Flopped
Authors: F.J. Ingelfinger
Journal: New England Journal of Medicine (1976)

The ideas and information between the covers of a medical journal are the principal concerns of those who manage the publication, but managers also indulge in other worries, especially in what might be called technical traits. Included under this rubric are such features as a journal's physical characteristics, its literary style, its typography and its format. Over the years, management of the New England Journal of Medicine has manipulated this or that technical trait in an effort to improve appeal and usefulness. Some of these efforts were successful but others were dismal failures, signaled, as a rule, not by explicit . . .
Still moving toward environmental justice.
Authors: R Clay
Journal: Environmental Health Perspectives (1999)

Three years in the making, the Institute of Medicine report Toward Environmental Justice was funded by a consortium of agencies, including the NIEHS, the Centers for Disease Control and Prevention, the U.S. Environmental Protection Agency, and the U.S. Department of Energy. The independent review was authored by a 15-member committee that represented academia, public interest, medicine, law, and industry. The committee met with stakeholders, citizens, public officials, and industry representatives around the United States to assess the need for better research, education, and health policy related to environmental justice. The report investigates the situation of groups of individuals suspected of having disproportionately high levels of exposure to environmental stressors such as chemicals, biologics, allergenics, toxicants, light, noise, odors, and particulate matter. The report calls for more research to help identify and verify the environmental etiologies of diseases. It also recommends that citizens be recruited to participate in the design and execution of the research, and that communication during all phases of the research be open and reciprocal.
Arginine feeding modifies cyclosporine nephrotoxicity in rats.
Authors: L De Nicola, S C Thomson, L M Wead, M R Brown, F B Gabbai
Journal: Journal of Clinical Investigation (1993)

Glycine (G) infusion causes renal vasodilation mediated by nitric oxide (NO). Cyclosporine A (CsA) nephrotoxicity is characterized by preglomerular vasoconstriction and decreased efferent arteriolar tone probably related to reduced NO and angiotensin II, respectively. L-Arginine (ARG) is a precursor to NO. To test the hypothesis that chronic CsA decreases renal NO activity, we compared the glomerular hemodynamic response to glycine infusion in rats after 8 d of CsA (30 mg/kg per d s.c.), CsA and ARG (1.6 g/kg per d p.o.) (A/CsA), and in two groups of pair-fed controls (CON, A/CON). Single nephron GFR (SNGFR), single nephron plasma flow (SNPF), glomerular capillary hydrostatic pressure gradient (delta P), proximal tubular reabsorption (APR), and kidney tissue angiotensin II (AIIk) were measured before and during G. CsA was associated with baseline decrements in SNGFR, SNPF, delta P, and AIIk, and with a blunted hemodynamic response to G. In CON, ARG did not affect baseline hemodynamics or modify the response to G. In CsA, ARG decreased baseline preglomerular resistance and restored the glomerular hemodynamic response to G. G was associated with a significant increase in AIIk in both CON and CsA. These findings suggest that (a) CsA is associated with decreased AIIk, and (b) CsA may diminish NO activity within the kidney, and that this capacity may be partially restored by arginine feeding.
On the Weighted-Average Relationship Between Plasma Glucose and HbA1c
Authors: Yasuhiro Tahara
Journal: Diabetes Care (2006)

Dr. Trevino (1) has derived a mathematical formula for HbA1c (A1C) change in response to exponential plasma glucose decay. His analysis has shown a faster decay of A1C associated with a slower decay of plasma glucose and posed a question to the weighted-average relationship between plasma glucose and A1C, which we proposed in our previous study (2). Since his derived formula is very complicated and the detailed analytical method is not given, I cannot exactly reply to his question. However, I propose here a new physiological model, which deals with the …
Mutations in the deubiquitinase gene USP8 cause Cushing's disease
Authors: Martin Reincke, Silviu Sbiera, Akira Hayakawa, Marily Theodoropoulou, Andrea Osswald, Felix Beuschlein, Thomas Meitinger, Emi Mizuno-Yamasaki, Kohei Kawaguchi, Yasushi Saeki, Keiji Tanaka, Thomas Wieland, Elisabeth Graf, Wolfgang Saeger, Cristina L Ronchi, Bruno Allolio, Michael Buchfelder, Tim M Strom, Martin Fassnacht, Masayuki Komada
Journal: Nature Genetics (2014)
ARE VON WILLEBRAND FACTOR AND FACTOR 8 ASSOCIATED WITH CARDIOVASCULAR EVENTS INCLUDING HEART FAILURE IN NON-VALVULAR ATRIAL FIBRILLATION?
Authors: Emmanuelle Berthelot Garcias, Stephane Ederhy, Sylvie Lang, Louise Boyer-Chatenet, Ghislaine Dufaitre, Emanuele Di Angelantonio, Catherine Meuleman, Nabila Haddour, Fanny Douna, Franck Boccara, Ariel Cohen
Journal: Journal of the American College of Cardiology (2011)
Frictional Dermatitis of Onan
Authors: Joseph L. Jorizzo
Journal: JAMA (1983)

<h3>To the Editor.—</h3> We wish to report a heretofore unlabelled condition that we believe to be a not rare male affliction. Five men, aged 22 to 40 years, were seen at the dermatology clinic at the University of Texas Medical Branch, Galveston, over a four-month period in late 1982 with a distinctive penile dermatitis that we attributed to masturbation. In each case, patients complained of a pruritic penile eruption of one to three weeks' duration. Physical examinations disclosed subacute to chronic eczema on the penile corona and, in one patient, shaft. A linear distribution of lesions suggested an exogenous origin for the dermatitis. In more chronic cases, lichenification and hyperpigmentation were appreciated. Evaluation included exclusion by history of causes of penile allergic contact dermatitis,<sup>1</sup>potassium hydroxide preparation to exclude candidosis, Gram's stain to exclude bacterial infection, and a VDRL test. History and complete cutaneous examination did not support diagnoses
HFE mutations, hepatic iron, and fibrosis: Ethnic-specific association of NASH with C282Y but not with fibrotic severity
Authors: Shivakumar Chitturi, Martin Weltman, Geoffrey C. Farrell, David McDonald, Christopher Liddle, Dev Samarasinghe, Rita Lin, Shehan Abeygunasekera, Jacob George
Journal: Hepatology (2002)

There is conflicting evidence regarding inheritance of hemochromatosis gene (HFE) mutations and influence of hepatic iron deposition as cofactors for development of fibrosis in patients with nonalcoholic steatohepatitis (NASH). We studied hepatic iron content (Perls’ stain grade), frequency of HFE mutations, and serum iron indices in 93 patients with NASH from a multiethnic background; 59 (63%) were of Anglo-Celtic origin. Data on C282Y mutations were available for all 93 patients and on H63D for 69 patients. Respective controls were 206 (for C282Y, 141 [69%] of whom were Anglo-Celtic) and 180 (for H63D) blood donors. Hyperferritinemia was present in 38 patients (40%) with NASH, but transferrin saturation was increased (&gt;55%) in only 5 (5%). Liver biopsy specimens showed advanced fibrosis in 31 (33%) (cirrhosis in 20%). Altogether, 9 biopsy specimens (10%) showed increased iron: 7 (8%) with grade 2 and 2 (2%) with grade 3 iron staining. Only 1 biopsy specimen with increased iron showed advanced fibrosis. The frequency of C282Y heterozygosity was increased in Anglo-Celtic patients with NASH compared with ethnic blood donor controls (22% vs. 9.2%; P = .035); there were no C282Y homozygotes in the NASH cohort. Although there was a trend toward higher serum ferritin levels among C282Y heterozygotes with NASH, there were no differences in histologic grades of steatosis, inflammation, or fibrosis between individuals with and without C282Y. The frequencies of compound C282Y/H63D heterozygotes (n = 1) or H63D heterozygotes (n = 10) were not increased in NASH. Multivariate analysis identified female sex, diabetes mellitus, and more severe liver inflammation but not HFE mutations, serum ferritin, iron saturation, or hepatic iron staining as independent predictors of hepatic fibrosis. In conclusion, hepatic iron is not a factor linked to hepatic fibrogenesis in patients with NASH. HFE mutations do not confer an additional risk of hepatic fibrosis in this disorder.
Human Radiation Injury
Authors: Curtis W. Bakal
Journal: JAMA (2011)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal