tbuckley/cabot-search huggingface dataset:
Primitive Long-Term Culture Initiating Cells (LTC-ICs) in Granulocyte Colony-Stimulating Factor Mobilized Peripheral Blood Progenitor Cells Have Similar Potential for Ex Vivo Expansion as Primitive LTC-ICs in Steady State Bone Marrow
Authors: Felipe Prosper, Kirk Vanoverbeke, David Stroncek, Catherine M. Verfaillie
Journal: Blood (1997)
Epstein-Barr Virus-Immune Complexes in Postmortem Kidneys From African Patients With Burkitt's Lymphoma and American Patients With and Without Lymphoma
Authors: J. C. Sutherland, C. L. M. Olweny, P. H. Levine, M. R. Mardiney
Journal: JNCI Journal of the National Cancer Institute (1978)

Journal Article Epstein-Barr Virus-Immune Complexes in Postmortem Kidneys From African Patients With Burkitt's Lymphoma and American Patients With and Without Lymphoma Get access J. C. Sutherland, J. C. Sutherland Search for other works by this author on: Oxford Academic PubMed Google Scholar C. L. M. Olweny, C. L. M. Olweny Search for other works by this author on: Oxford Academic PubMed Google Scholar P. H. Levine, P. H. Levine Search for other works by this author on: Oxford Academic PubMed Google Scholar M. R. Mardiney, Jr. M. R. Mardiney, Jr. Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 60, Issue 5, May 1978, Pages 941–946, https://doi.org/10.1093/jnci/60.5.941 Published: 01 May 1978 Article history Received: 17 May 1977 Revision received: 25 October 1977 Accepted: 25 November 1977 Published: 01 May 1978
Cocarcinogenic Activity of Peroxy Compounds
Authors: Fred G. Bock, Huston K. Myers, Helen W. Fox
Journal: JNCI Journal of the National Cancer Institute (1975)

Peracetic acid was a potent tumor promoter and a weak complete carcinogen on the skin of female ICR Swiss mice. "Decomposed peracetic acid" was inactive as a tumor promoter, as were 3% [hydrogen peroxide and 5%] urea peroxide; 1% perbenzoic acid and m-chloroperbenzoic acid were active tumor prototers.
Evaluation of vitamin D in bronchial asthma and its correlation with lung function
Authors: Balakrishnan Menon, Gaki Nema, Charanjeet Kaur
Journal: European Respiratory Journal (2013)

BACKGROUND : 

Low levels of vitamin D (VitD) has been associated with poor asthma control and reduced lung function. Also higher VitD levels are associated with decreased airway hyperresponsiveness and decreased inflammatory markers.

AIMS : 

To evaluale VitD levels in asthmatics and to correlate it with lung function

METHODS : 

One hundred forty three new patients of asthma were recruited and classified as per GINA guidelines. Spirometry was performed and VitD (25 OH Cholecalceferol) was estimated by ELISA method. VitD was also estimated in 10 healthy volunteers for control purposes.

RESULTS : 

Of the 143 asthmatics, 34 were in mild persistent group, 74 were moderate persistent and 35 were in severe persistent group.

The mean value of VitD in asthmatics was 16.43±8.4ng/ml and in controls was 28.21+4.7ng/ml. The difference in means was found to be highly significant (p<0.01). The mean FVC in asthmatics was 3.26±0.8L. The FEV1 was 2.41±0.7L.

The mean VitD levels in mild persistent group was 18.68±8.3ng/ml, in moderate persistent group was 16.42±9.4ng/ml and in severe persistent group was 14.33±5.9ng/ml. The difference of means was significant (p<0.05).

Significant positive correlation was found between FEV1 and FVC (p<0.01) and between VitD and serum total IgE levels (p<0.05). However no significant correlation was obtained between VitD levels and FVC and FEV1.

CONCLUSION : 

Vitamin D levels were found to be low in both controls and patients of asthma. The difference in VitD levels between asthmatics and controls was highly significant. Also the difference in VitD levels between the different stages of asthma was significant. No significant correlation was obtained between VitD levels and lung function parameters.
Prediction of adult-onset schizophrenia from childhood home movies of the patients
Authors: E Walker, R J Lewine
Journal: American Journal of Psychiatry (1990)

In a preliminary study of developmental precursors of schizophrenia, home movies of adult-onset schizophrenic patients and their healthy siblings filmed during their childhood were viewed by judges who were blind to the psychiatric outcome of the subjects. The films began with the infancy of all subjects and extended through at least the first 5 years of their lives. Although none of the subjects had any psychiatric disorder in childhood, the preschizophrenic children were reliably identified by the viewers. This represents the first demonstration that preschizophrenic subjects can be distinguished from sibling control subjects within the first 8 years of life by observing their behavior.
A portable device for assessment of daytime sleepiness
Authors: Miaofang Liu, Yuanming Luo, Nanshan Zhong
Journal: European Respiratory Journal (2012)

Many studies have shown that sleepiness is a major cause of traffic accidents. Patients with obstructive sleep apnoea usually have daytime sleepiness. Epworth sleepiness scale has been used to subjectively assess daytime sleepiness in patients with OSA, but it was far from perfect. Osler test was a useful alternatively objective test for daytime sleepiness and has been used in clinical practice. However, Osler test was usually performed in hospital. It is important to develop an easy-to-use portable device to assess daytime sleepiness at home. We have recently developed a portable device based on the principles of Osler test. The purpose of the present study was to determine whether the onset of sleep detected by our portable device was the same as that detected by conventional polysomnography. Eight patients with OSA and eight normal subjects were studied. Sleep latency as judged by portable device was the same as that judged by conventional polysomnography and sleep latency measured from patients with OSA (18.1±9.1 minutes) was significantly shorter than that measured from normal subjects (> 40minutes), p  This work was funded by NSFC (Grant No. 81120108001).
Efficacy of short-course oral prednisolone in polymorphic light eruption: a randomized controlled trial
Authors: D.C. Patel, G.J. Bellaney, P.T. Seed, J.M. Mcgregor, J.L.M. Hawk
Journal: British Journal of Dermatology (2000)

Journal Article Efficacy of short‐course oral prednisolone in polymorphic light eruption: a randomized controlled trial Get access D.C. Patel, D.C. Patel Photobiology Unit, Department of Environmental Dermatology, St John's Institute of Dermatology, St Thomas' Hospital, London SE1 7EH, U.K. Search for other works by this author on: Oxford Academic Google Scholar G.J. Bellaney, G.J. Bellaney Photobiology Unit, Department of Environmental Dermatology, St John's Institute of Dermatology, St Thomas' Hospital, London SE1 7EH, U.K. Search for other works by this author on: Oxford Academic Google Scholar P.T. Seed, P.T. Seed Department of Public Health Sciences, Guy's, King's and St Thomas' School of Medicine, King's College London, London, U.K. Search for other works by this author on: Oxford Academic Google Scholar J.M. Mcgregor, J.M. Mcgregor Photobiology Unit, Department of Environmental Dermatology, St John's Institute of Dermatology, St Thomas' Hospital, London SE1 7EH, U.K. Search for other works by this author on: Oxford Academic Google Scholar J.L.M. Hawk J.L.M. Hawk Photobiology Unit, Department of Environmental Dermatology, St John's Institute of Dermatology, St Thomas' Hospital, London SE1 7EH, U.K. Professor J.L.M.Hawk . Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 143, Issue 4, 1 October 2000, Pages 828–831, https://doi.org/10.1046/j.1365-2133.2000.03840.x Published: 01 October 2000
Progress and remaining challenges for cancer control in Latin America and the Caribbean
Authors: Kathrin Strasser-Weippl, Yanin Chavarri-Guerra, Cynthia Villarreal-Garza, Brittany L Bychkovsky, Marcio Debiasi, Pedro E R Liedke, Enrique Soto-Perez-de-Celis, Don Dizon, Eduardo Cazap, Gilberto de Lima Lopes, Diego Touya, Joāo Soares Nunes, Jessica St Louis, Caroline Vail, Alexandra Bukowski, Pier Ramos-Elias, Karla Unger-Saldaña, Denise Froes Brandao, Mayra E Ferreyra, Silvana Luciani, Angelica Nogueira-Rodrigues, Aknar Freire de Carvalho Calabrich, Marcela G Del Carmen, Jose Alejandro Rauh-Hain, Kathleen Schmeler, Raúl Sala, Paul E Goss
Journal: The Lancet Oncology (2015)
Antitumor activity of MEK and PI3K inhibitors in malignant pleural mesothelioma
Authors: Seigo Miyoshi, Hironobu Hamada, Naohiko Hamaguchi, Hitoshi Katayama, Kazunori Irifune, Ryoji Ito, Tatsuhiko Miyazaki, Jitsuo Higaki
Journal: European Respiratory Journal (2011)

Background:  Malignant pleural mesothelioma (MPM) is an aggressive malignancy, and there is no approved targeted therapy for this disease.   Objective:  We investigated the role of mitogen-activated protein kinase kinase (MEK) inhibitor and phosphatidylinositol 3-kinase (PI3K) inhibitor as targeted therapies for MPM.   Method:  We examined the therapeutic efficacy of the MEK or PI3K inhibitor against human MPM cell line EHMES-10 both in vitro and orthotopically inoculated into severe combined immunodeficient (SCID) mice. In addition, the molecular mechanisms of these agents were confirmed  in vitro  and  in vivo  experiments.   Results:  MEK or PI3K inhibitor suppressed the growth of MPM model in dose dependent manner both  in vitro  and  in vivo  studies. In addition, combining MEK inhibitor with PI3K inhibitor resulted in an additive growth inhibitory effect. EHMES-10 cells showed increasing the G1 cell cycle arrest and apoptosis by treatment of MEK or PI3K inhibitor  in vitro . Western blot analysis  in vitro  and  in vivo  study showed increasing the p27 kip1  and cleaved PARP expression and decreasing the Cyclin E, CyclinD1 and procaspase 3 expressions. In addition, these agents decreased the expression of hypoxia-inducible factor 1α and vascular endothelial growth factor, which play an essential role in tumor angiogenesis and progression.   Conclusion:  Our results suggest that MEK or PI3K inhibitor is a promising therapeutic strategy, and also provide a basis for useful combination of MEK and PI3K inhibitors in patients with MPM.
Hyperinflation-Induced Lung Injury during Alveolar Flooding in Rats
Authors: DIDIER DREYFUSS, LAURENT MARTIN-LEFÈVRE, GEORGES SAUMON
Journal: American Journal of Respiratory and Critical Care Medicine (1999)

Mechanical nonuniformity of diseased lungs may predispose them to ventilator-induced lung injury (VILI) by overinflation of the more compliant, aerated zones. Perfluorocarbon (PFC) may reduce this nonuniformity by suppressing air-liquid interfaces. Saline (6.8 ml/kg) was instilled into the trachea to mimic alveolar edema and reduce aerated lung volume before mechanical ventilation (6, 16, 24, or 32 ml/kg tidal volume [VT]) for 10 min in rats. Flooding significantly aggravated VILI when VT was 24 or 32 ml/kg, with an increase in the distribution space of albumin in lungs (p < 0.001). Tracheal instillation of a low dose (3.3 ml/kg) of PFC (Liquivent) either before or after the instillation of saline considerably reduced VILI (p < 0.001). Saline instillation raised the lower inflection point of the respiratory system pressure-volume curve to values as high as 25 cm H2O, and produced a significant increase in end-inspiratory pressure (from 38 +/- 2.0 cm H2O to 61 +/- 2.4 cm H2O, for a VT of 32 ml/kg; p < 0.001). PFC significantly reduced the pressure at the lower inflection point and normalized end-inspiratory pressure. These decreases were correlated with a smaller albumin distribution space (p < 0.001). Animals in which PFC instillation failed to reduce the albumin space had pressures similar to those of animals given saline alone. In conclusion, the effectiveness of PFC instillation in reducing VILI may be predicted by the shape of the pressure-volume curve. These findings may help in designing safer clinical studies of mechanical ventilation and in reducing the cost of partial liquid ventilation by reducing doses of PFC.
Seasonal variations in sexual activity and their implications for sexual health promotion
Authors: K Wellings, W Macdowall, M Catchpole, J Goodrich
Journal: Journal of the Royal Society of Medicine (1999)

Although seasonal variations in births are observed in all human populations, the links between calendar events and sexual activity have received little attention in relation to health promotion and service provision. We have plotted various relevant data--routinely collected data for births within and outside of marriage, abortions, sexually transmitted infections, human immunodeficiency virus tests and condom sales figures--by calendar period. The trends point consistently to an increase in sexual activity and unsafe sex occurring at or around the Christmas period, and a longer but less pronounced subsidiary period of increased sexual activity and unsafe sex coinciding with the summer vacation. We conclude that seasonal patterns of sexual activity have implications for provision of sexual health services and for the timing and targeting of sexual health promotional interventions.
Extended-spectrum β-lactamase producing Klebsiella spp. in chicken meat and humans: a comparison of typing methods
Authors: I.T.M.A. Overdevest, M. Heck, K. van der Zwaluw, X. Huijsdens, M. van Santen, M. Rijnsburger, A. Eustace, L. Xu, P. Hawkey, P. Savelkoul, C. Vandenbroucke-Grauls, I. Willemsen, J. van der Ven, C. Verhulst, J.A.J.W. Kluytmans
Journal: Clinical Microbiology and Infection (2013)

Recently, chicken meat was identified as a plausible source of extended-spectrum β-lactamase (ESBL) -producing Escherichia coli in humans. We investigated the relatedness of ESBL-producing Klebsiella spp. in chicken meat and humans. Furthermore, we tested the performance of SpectraCell RA® (River Diagnostics), a new typing method based on Raman spectroscopy, in comparison with multilocus sequence typing (MLST) for Klebsiella pneumoniae. Twenty-seven phenotypically and genotypically confirmed ESBL-producing Klebsiella spp. isolates were typed with MLST and SpectraCell RA. The isolates derived from chicken meat, human rectal swabs and clinical blood cultures. In the 22 ESBL-producing K. pneumoniae isolates, CTX-M15 was the predominant genotype, found in five isolates of human origin and in one chicken meat isolate. With MLST, 16 different STs were found, including five new STs. Comparing the results of SpectraCell RA with MLST, we found a sensitivity of 70.0% and a specificity of 81.8% for the new SpectraCell RA typing method. Therefore, we conclude that SpectraCell RA is not a suitable typing method when evaluating relationships of ESBL-producing Klebsiella spp. at the population level. Although no clustering was found with isolates of chicken meat and human origin containing the same ESBL genes, MLST showed no clustering into distinctive clones of isolates from chicken meat and human origin. More studies are needed to elucidate the role of chicken meat in the rise of ESBL-producing Klebsiella spp. in humans.
Chromosome 1 Abnormalities: A Common Feature of Pediatric Solid Tumors&lt;xref ref-type="fn" rid="FN2"&gt;2&lt;/xref&gt;&lt;xref ref-type="fn" rid="FN3"&gt;3&lt;/xref&gt;
Authors: E C Douglass, A A Green, F A Hayes, E Etcubanas, M Horowitz, J A Wilimas
Journal: JNCI Journal of the National Cancer Institute (1985)

Abnormalities of chromosome 1 were found in 32 of 46 pediatric solid tumors including Ewing's sarcoma, Wilms' tumor, rhabdomyosarcoma, primitive neuroectodermal tumor, and hepatoblastoma. Trisomy of 1q was the most common abnormality, and breakpoints were most frequent in the region 1cen to 1p22. Abnormalities of chromosome 1 are not specific to any type of tumor. However, their frequent occurrence indicates that they may endow a clonal advantage in the development of cancer.
Flexible dosing schedules of panitumumab (ABX-EGF) in cancer patients
Authors: R. Arends, B. B. Yang, G. Schwab, P. Lockbaum, C. Funelas, L. Roskos
Journal: Journal of Clinical Oncology (2005)

3089 Background Panitumumab is a fully human monoclonal antibody directed against the EGFr. In a Phase 1 trial in patients with colorectal, NSCL, renal, prostate, pancreatic, or esophageal cancer, the optimum weekly dose was determined to be 2.5 mg/kg (Roskos et al, ASCO 2002, Abstract 362). To allow for more convenient dosing, every 2 week (Q2W) or every 3 week (Q3W) dosing intervals were evaluated in the same Phase 1 trial. Methods: PK data from weekly doses in the range of 0.1 mg/kg to 5 mg/kg were fitted by a 2-compartment model with elimination of panitumumab occurring simultaneously via a Michaelis-Menten pathway and a first-order linear pathway. This model was used to simulate Q2W and Q3W regimens achieving serum trough panitumumab concentrations around 50 μg/mL, as was measured for the steady-state trough levels at the 2.5 mg/kg weekly dose. The model predicted that the trough concentration after three doses of 6 mg/kg Q2W or 9 mg/kg Q3W would be 53 and 47 μg/mL respectively. Patients were enrolled in 6 mg/kg Q2W (n=17) and 9 mg/kg (n=23) cohorts, with intensive PK sampling after the first and the third doses. Results Preliminary results indicate mean (SE) trough concentrations for 6 mg/kg Q2W and 9 mg/kg Q3W regimens after 3 doses were 49 (4) and 45 (8) μg/mL, respectively, consistent with simulations. The inter-individual variability in PK was low in both cohorts at CV ≤ 20%. After a single dose the mean (SD) Cmax was 147 (25) and 227 (45) μg/mL for the Q2W and the Q3W regimen respectively and the mean (SD) AUClast was 853 (173) and 1627 (293) μg*day/mL for the Q2W and the Q3W regimens respectively. Both regimens were generally well tolerated with a safety profile comparable to 2.5 mg/kg weekly. Conclusion Panitumumab administered at 6 mg/kg Q2W or 9 mg/kg Q3W resulted in exposure and tolerability profiles comparable to 2.5 mg/kg weekly, demonstrating the ability to dose panitumumab flexibly for enhanced patient convenience. Panitumumab exhibited predictable PK, with low inter- and intra-patient variability. Author Disclosure Employment or Leadership Consultant or Advisory Role Stock Ownership Honoraria Research Funding Expert Testimony Other Remuneration Abgenix, Amgen Abgenix, Amgen
The Efficacy of Exposure Therapy for Anxiety-Related Disorders and Its Underlying Mechanisms: The Case of OCD and PTSD
Authors: Edna B. Foa, Carmen P. McLean
Journal: Annual Review of Clinical Psychology (2015)

In this review we describe the intricate interrelationship among basic research, conceptualization of psychopathology, treatment development, treatment outcome research, and treatment mechanism research and how the interactions among these areas of study further our knowledge about psychopathology and its treatment. In describing the work of Edna Foa and her colleagues in anxiety disorders, we demonstrate how emotional processing theory of anxiety-related disorders and their treatment using exposure therapy have generated hypotheses about the psychopathology of posttraumatic stress disorder and obsessive-compulsive anxiety disorder that have informed the development and refinement of specific treatment protocols for these disorders: prolonged exposure and exposure and response (ritual) prevention. Further, we have shown that the next step after the development of theoretically driven treatment protocols is to evaluate their efficacy. Once evidence for a treatment's efficacy has accumulated, studies of the mechanisms involved in the reduction of the targeted psychopathology are conducted, which in turn inform the theory and further refine the treatments. We conclude our review with a discussion of how the knowledge derived from Foa and colleagues' programmatic research together with knowledge emerging from basic research on extinction learning can inform future research on the psychopathology of anxiety disorders and their treatments.
Parent-Adolescent Communication About Contraception and Condom Use
Authors: Vincent Guilamo-Ramos, Jane J. Lee, James Jaccard
Journal: JAMA Pediatrics (2015)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Pediatrics HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Pediatrics journal
Molecular evidence for the inclusion of cetaceans within the order Artiodactyla.
Authors: D Graur, D G Higgins
Journal: Molecular Biology and Evolution (1994)

The transition in the cetaceans from terrestrial life to a fully aquatic existence is one of the most enduring evolutionary mysteries. Resolving the phylogenetic relationships between Cetacea and the other orders of eutherian mammals may provide us with important clues to the origin of whales and may help us date the evolutionary transition to aquatic life. Previous paleontological and molecular evidence has indicated that cetaceans and artiodactyls constitute a natural clade within subclass Eutheria. Our present phylogenetic analyses of protein and mitochondrial DNA sequence data indicate that cetaceans are not only intimately related to the artiodactyls; they are in fact deeply nested within the artiodactyl phylogenetic tree; i.e., they are more closely related to the members of one suborder of artiodactyls, the Ruminantia, than either ruminants or cetaceans are to members of the other two artiodactyl suborders: Suiformes and Tylopoda. On the basis of the rate of evolution of mitochondrial DNA sequences and using paleontological reference dates for calibration, we estimate that the whale lineage has branched off a protoruminant lineage < 50 Mya. By implication, the cetacean transition to aquatic life is inferred to be a relatively recent evolutionary event.
Lung cancer in women: What are particularities?
Authors: Rihab Bay, Soumaya Ben Saad, Hafaoua Daghfous, Hala Cherif, Fatma Tritar
Journal: European Respiratory Journal (2014)

Introduction:  Lung cancer (LC) is becoming more and more common in women where it presents significant differences at both clinical and therapeutic levels.  Objectives:  Evaluate clinical, therapeutic and prognostic features of LC in female patients.  Methods:  Our study include164 patients witch were treated for LC between 2006 and 2013: 29 women (G1) and 135 men (G2). These two groups (G1 and G2) were compared (age, past history, interventions, TNM stage and long term survival).  Results:  Mean age of patients was 62 years in the 2 groups. Smoking is significantly higher in G2 (97% vs 18,5%; p  Conclusion:  Because less comorbidities, better PS and better chemosensitivity female patients with LC have better prognosis.