RENAL MANIFESTATIONS OF SYSTEMIC LUPUS ERYTHEMATOSUS; A CLINICAL AND PATHOLOGIC STUDY OF 90 CASES
Authors: Louis J. Suffer, A. Louis Southren, H. E. Weiner, R. L. Wolf
Journal: Annals of Internal Medicine (1961)

Article1 February 1961RENAL MANIFESTATIONS OF SYSTEMIC LUPUS ERYTHEMATOSUS; A CLINICAL AND PATHOLOGIC STUDY OF 90 CASESLOUIS J. SUFFER, M.D., F.A.C.P., A. LOUIS SOUTHREN, M.D., H. E. WEINER, M.D., R. L. WOLF, M.D.LOUIS J. SUFFER, M.D., F.A.C.P.Search for more papers by this author, A. LOUIS SOUTHREN, M.D.Search for more papers by this author, H. E. WEINER, M.D.Search for more papers by this author, R. L. WOLF, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-54-2-215 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe present report is concerned with a study of the renal manifestations in 90 patients with systemic lupus erythematosus who were seen at the Mount Sinai Hospital from 1949 to 1959. The role of various factors in the pathogenesis of the renal disease is examined. Consideration is given to a correlation between the clinical and laboratory evidence of renal damage and the histologic study of kidney tissue. An attempt has been made to determine the value of corticotropin and the glucogenic steroids in the management of the renal complications. Only those cases are included which demonstrated characteristic clinical and laboratory...Bibliography1. DavisGutridge MWGH: Disseminated lupus erythematosus in identical twin sisters, associated with diabetes mellitus in one case. J. Missouri State Med. Ass. 48: 446, 1951. Google Scholar2. Soffer LJ: The therapy of systemic lupus erythematosus. J. Mt. Sinai Hosp. 26: 297, 1959. MedlineGoogle Scholar3. RaceSanger RRR: Blood groups in man. 2d ed., pp. 358-359, Charles C Thomas, Springfield, Illinois, 1954. Google Scholar4. KuhnsBauerlein WJTC: Exchange transfusions in hemolytic anemia complicating disseminated lupus erythematosus. Arch. Intern. Med. 92: 284, 1953. CrossrefGoogle Scholar5. McCombsPatterson RPJF: Factors influencing the course and prognosis of systemic lupus erythematosus. New Engl. J. Med. 260: 1195, 1959. CrossrefMedlineGoogle Scholar6. SofferBader LJR: Corticotropin and cortisone in acute disseminated lupus erythematosus: results of long-term use. J. A. M. A. 149: 1002, 1952 CrossrefMedlineGoogle Scholar7. SofferLudermannBrill LJHHG: Effect of corticotropin and adrenal steroids on the management of acute disseminated lupus erythematosus. Ann. N. Y. Acad. Sci. 61: 418, 1955. CrossrefMedlineGoogle Scholar8. MuehrckeKarkPiraniPollak RCRMCLVE: Lupus nephritis: a clinical and pathologic study based on renal biopsies. Medicine 36: 1, 1957. MedlineGoogle Scholar9. DoughertyBagenstross GWAH: Syndrome characterized by glomerulonephritis and arthritis, Libman-Sachs disease with predominantly renal involvement. Arch. Intern. Med. 85: 900, 1950. CrossrefGoogle Scholar10. BermanSchreiner LBGE: Clinical and pathologic spectrum of the nephrotic syndrome. Amer. J. Med. 24: 249, 1958. CrossrefMedlineGoogle Scholar11. JessarLamont-HoversRagan RARWC: Natural history of lupus erythematosus disseminatus. Ann. Intern. Med. 38: 717, 1953. LinkGoogle Scholar12. KlempererGueftLeeLeuchtenbergerPollister PBSLCAW: Cytochemical changes of acute lupus erythematosus. Arch. Path. 49: 503, 1950. Google Scholar13. SofferOrr LJRH: Editorial statement in Symposium: Newer hydrocortisone analogues. Metabolism 7: part 2, 383, 1958. MedlineGoogle Scholar14. PollackPiraniKarkMuehrcke VECLRMRC: Effect of large doses of prednisone on renal lesions of lupus glomerulonephritis. Clin. Res. 7: 285, 1959. Google Scholar15. Holman H: Systemic lupus erythematosus. J. Pediat. 56: 109, 1960. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: New York, N. Y.*Received for publication June 16, 1960.From the Endocrine Research Laboratory and Clinic of the Department of Medicine of the Mount Sinai Hospital, New York, N. Y.†Aided by Grant A-921 from the National Institutes of Health.‡Present address: The Jewish Hospital of Brooklyn, Brooklyn, N. Y.We are indebted to the Schering Corporation for the generous supply of Meticortelone and Meticorten; to the Upjohn Company for Medrol; to Wyeth Laboratories for Bicillin; and to the Lederle Laboratories for gamma globulin.Requests for reprints should be addressed to Louis J. Soffer, M.D., Attending Physician and Head of Endocrinology, Mount Sinai Hospital, Fifth Avenue and One Hundredth St., New York 29, New York. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byThe American college of rheumatology response criteria for proliferative and membranous renal disease in systemic lupus erythematosus clinical trialsThe Value of Electron Microscopy in the Diagnosis and Clinical Management of Lupus NephritisOutcome of silent lupus nephritisBilateral Kidney Disease and HypertensionTreatment of systemic lupus erythematosus: which options do we have for therapy regimens?Prevention of Renal FailureThe treatment of lupus nephritisSystemic lupus erythematosus without clinical renal abnormalities: renal biopsy findings and clinical course.Natural History of Hypertension in Renal Parenchymal DiseaseMortality in lupus nephritisLupus NephritisCyclophosphamide or Azathioprine in Lupus Glomerulonephritis A Controlled Trial: Results at 28 MonthsJOHN L. DECKER, M.D., F.A.C.P., JOHN H. KLIPPEL, M.D., PAUL H. PLOTZ, M.D., ALFRED D. STEINBERG, M.D.The heart in systemic lupus erythematosus and the changes induced in it by corticosteroid therapyA double-blind controlled trial comparing cyclophosphamide, azathioprine and placebo in the treatment of lupus glomerulonephritisRenal histology and clinical course of systemic lupus erythematosusMorphologie und Lokalisation der H�matoxylink�rperchen bei LupusnephritisPsychopathology in systemic lupus erythematosus. II. Relation to clinical observations, corticosteroid administration, and cerebrospinal fluid C4The distribution and character of glomerular deposits in systemic lupus erythematosusActive Lupus Glomerulitis and Hematoxylin Bodies with Normal UrinalysisCyclophosphamide in Lupus Nephritis: A Controlled TrialALFRED D. STEINBERG, M.D., H. BENFER KALTREIDER, M.D., PARKER J. STAPLES, M.D., EDWARD J. GOETZL, M.D., NORMAN TALAL, M.D., JOHN L. DECKER, M.D., F.A.C.P.S.L.E.-LIKE REACTION AFTER PHENYLBUTAZONENEPHROTIC SYNDROME WITH LYMPHOMADiagnosis and Treatment of Lupus NephritisThe Clinical Course of the Proliferative and Membranous Forms of Lupus NephritisDAVID S. BALDWIN, M.D., JEROME LOWENSTEIN, M.D., NAOMI F. ROTHFIELD, M.D., GLORIA GALLO, M.D., ROBERT T. MCCLUSKEY, M.D.Zur Klinik und Prognose der Nierenmanifestationen bei Lupus erythematodesAlternate-Day Steroid Therapy in Lupus NephritisGEORGE L. ACKERMAN, M.D., F.A.C.P.Doppelseitige hämatogene NierenerkrankungenThe Prognosis of Lupus Nephritis Role of Clinical-Pathologic CorrelationsBURTON ZWEIMAN, M.D., F.A.C.P., JOAN KORNBLUM, M.D., JOHN CORNOG, M.D., EUGENE A. HILDRETH, M.D., F.A.C.P.The Hematological Aspects of a Case of Systemic Lupus ErythematosusNephrotisches Syndrom einschließlich renal bedingter ÖdemeNiere bei Tumoren, Blutkrankheiten und ParaproteinämienLupus NephritisDiagnosis and Treatment of Lupus NephritisThe Kidney in Systemic Lupus ErythematosusSteroid therapy of systemic lupus erythematosus based on immunologic considerationsGENERALIZED ARTERIAL AND ARTERIOLAR VASCULITIS WITH MARKED PLASMACYTOSIS AND HYPERGAMMAGLOBULINEMIA: REPORT OF AN AUTOPSY CASE†The Kidney Function in Patients with Rheumatoid Arthritis in Relation to the Commencement of the Disease (VI)Rheumatism and Arthritis Review of American and English Literature of Recent Years (Sixteenth Rheumatism Review)CHARLEY J. SMYTH, M.D., F.A.C.P., ROGER L. BLACK, M.D., CHARLES CHRISTIAN, M.D., MACK L. CLAYTON, M.D., F.A.C.S., DONALD F. HILL, M.D., F.A.C.P., JOSEPH LEE HOLLANDER, M.D., F.A.C.P., WILLIAM M. MIKKELSEN, M.D., F.A.C.P., MAX M. MONTGOMERY, M.D., F.A.C.P., CARL M. PEARSON, M.D., F.A.C.P., HUGH A. SMYTHE, M.D., F.R.C.P. (C), L. EMMERSON WARD, M.D., F.A.C.P., HOWARD J. WEINBERGER, M.D., F.A.C.P.Alterations in the histopathology of systemic lupus erythematosus with steroid therapySystemic lupus erythematosusNormocholesterolemic nephrotic syndrome of systemic lupus erythematosusThe Kidney Function in Patients with Rheumatoid Arthritis in Relation to the Commencement of the Disease (VI)Renal Disease in Systemic Lupus ErythematosusVasoactive polypeptidesSystemic Lupus Erythematosus and Pregnancy 1 February 1961Volume 54, Issue 2Page: 215-228KeywordsClinical laboratoriesExcretionHospital medicineKidneysLupus erythematosusRenal diseasesRenal systemResearch laboratoriesSteroidsStreptococcal infections ePublished: 1 December 2008 Issue Published: 1 February 1961 PDF downloadLoading ...