tbuckley/cabot-search huggingface dataset:
Two different cytochrome P450 enzymes are the adrenal antigens in autoimmune polyendocrine syndrome type I and Addison's disease.
Authors: O Winqvist, J Gustafsson, F Rorsman, F A Karlsson, O Kämpe
Journal: Journal of Clinical Investigation (1993)

Autoimmune polyendocrine syndrome type I (APS I) and idiopathic Addison's disease are both disorders with adrenal insufficiency but with differences in genetic background, clinical presentation, and extent of extraadrenal manifestations. In this study the major adrenal autoantigen identified with sera from patients with APS I was characterized by analyses using indirect immunofluorescence, Western blots of adrenal subcellular fractions and of recombinant proteins, immunoprecipitations of [35S]methionine-labeled lysates of a human steroid-producing cell line, and studies of enzymatic activity. Sera from patients with APS I, identifying cells in adrenal glands and testes involved in steroid synthesis, reacted in Western blots with a 53-kD antigen, which comigrated with the cytochrome P450 cholesterol side chain cleavage enzyme (SCC). The sera also immunoprecipitated this protein from lysates of radiolabeled adrenal cells. The enzymatic activity of SCC was inhibited by the APS I sera but not by control sera. Sera from patients with idiopathic Addison's disease did not react with the SCC. The results show that the autoimmune responses towards adrenal tissue in patients suffering from APS I and Addison's disease are remarkably selective and suggest that a determination of the antigen involved in a patient with autoimmune adrenal insufficiency will have diagnostic as well as prognostic implications.
Excitation-contraction coupling in rat myocardium: alterations with long term ethanol consumption
Authors: D. TEPPER, J. M CAPASSO, E. H SONNENBLICK
Journal: Cardiovascular Research (1986)

Journal Article Excitation-contraction coupling in rat myocardium: alterations with long term ethanol consumption Get access DAVID TEPPER, DAVID TEPPER From the Cardiovascular Research Center, Department of Medicine, Division of Cardiology, Albert Einstein College of Medicine, New York, USA Search for other works by this author on: Oxford Academic PubMed Google Scholar JOSEPH M CAPASSO, JOSEPH M CAPASSO From the Cardiovascular Research Center, Department of Medicine, Division of Cardiology, Albert Einstein College of Medicine, New York, USA Search for other works by this author on: Oxford Academic PubMed Google Scholar EDMUND H SONNENBLICK EDMUND H SONNENBLICK From the Cardiovascular Research Center, Department of Medicine, Division of Cardiology, Albert Einstein College of Medicine, New York, USA Search for other works by this author on: Oxford Academic PubMed Google Scholar Cardiovascular Research, Volume 20, Issue 5, May 1986, Pages 369–374, https://doi.org/10.1093/cvr/20.5.369 Published: 01 May 1986
Relationship between glomerular hyperfiltration and ACE insertion/deletion polymorphism in type 1 diabetic children and adolescents.
Authors: B Bouhanick, Y Gallois, S Hadjadj, F Boux de Casson, J M Limal, M Marre
Journal: Diabetes Care (1999)

OBJECTIVE: Glomerular hyperfiltration may predict diabetic nephropathy in type 1 diabetes, and some studies suggest that the ACE D allele is associated with diabetic nephropathy. The aim of this study was to examine a possible relationship between glomerular hyperfiltration and ACE insertion/deletion (I/D) polymorphism in type 1 diabetic children and adolescents. RESEARCH DESIGN AND METHODS: A cross-sectional study was conducted to examine the relationship between glomerular hyperfiltration and ACE (I/D) polymorphism in 76 type 1 diabetic children and adolescents without diabetic nephropathy (mean +/- SD: age 16 +/- 3 years; diabetes duration 7 +/- 4 years; age at diabetes onset 9 +/- 4 years; HbA1c 9.5 +/- 1.9%). Glomerular hyperfiltration (defined as a glomerular filtration rate [GFR] &amp;gt; or = 135 ml.min-1. 1.73 m-2 and by 51Cr-labeled EDTA plasma disappearance technique) and ACE I/D genotypes and plasma levels (enzyme-linked immunosorbent assay [ELISA] method) were determined. RESULTS: Of the patients, 29 (38%) displayed glomerular hyperfiltration. An association between glomerular hyperfiltration and ACE (I/D) polymorphism was observed (chi 2 = 7.09, P = 0.029) because of a reduced proportion of DD genotypes among patients with glomerular hyperfiltration (4 vs. 19; chi 2 = 6.03, P = 0.014) and not because of an excess of the II genotype (5 vs. 9; chi 2 = 0.04, P = 0.83). Age, diabetes duration, age at diabetes onset, and HbA1c were not different according to genotype. Patients with glomerular hyperfiltration had low plasma ACE levels, compared with those with normal glomerular filtration (457 +/- 157 vs. 553 +/- 186 micrograms/l; P = 0.027). CONCLUSIONS: These results suggest an unexpected association between glomerular hyperfiltration and ACE (I/D) polymorphism, characterized by a defect of the DD genotype among type 1 diabetic children and adolescents with glomerular hyperfiltration.
A molecular phylogeny of the bivalve mollusks
Authors: S. L. Adamkewicz, M. G. Harasewych, J. Blake, D. Saudek, C. J. Bult
Journal: Molecular Biology and Evolution (1997)

A phylogenetic reconstruction based on 506 nucleotides near the 5' end of the 18S subunit of ribosomal DNA (rDNA) in 2 gastropod, 3 chiton and 28 bivalve mollusks supported the monophyly and sister group relationship of the subclasses Heterodonta and Palaeoheterodonta but could not confidently establish either the monophyly or the phylogenetic relationships of the morphologically well defined subclasses Pteriomorphia, Protobranchia, and Anomalodesmata. When both gastropods and chitons were included in the analysis, one or the other invariably emerged within Bivalvia. Some evidence indicates that this apparent polyphyly may be the consequence of unequal rates of evolution and of rapid changes in the protobranch and anomalodesmatan lineages. The taxa usually included in Pteriomorpha emerge as a grade rather than a clade, although in a sequence that differs from morphologically based phylogenies.
Effects of Perhexiline on Coronary Hemodynamic and Myocardial Metabolic Responses to Tachycardia
Authors: CARL J. PEPINE, STEVEN J. SCHANG, CARL R. BEMILLER
Journal: Circulation (1974)

Coronary hemodynamic and myocardial metabolic responses before and after perhexiline administration were studied in 21 patients with coronary heart disease during pacing-induced angina pectoris. Perhexiline increased the threshold to tachycardia-induced angina pectoris in 16 of the 21 patients (HR 123 ± 3 to 134 ± 3 beats/min, P &lt; 0.01). Anaerobic myocardial lactate extraction was reduced by –6.1 ± 6.3 to 10.7 ± 4% after perhexiline, although lactate extraction declined in four patients and ST segment depression was not significantly changed. Myocardial oxygen extraction was enhanced, 64 ± 2 to 69 ± 2% ( P &lt; 0.05). Coronary flow as reflected by coronary sinus blood flow was not altered (165 ± 24 to 173 ± 26 cc/min) as left ventricular oxygen utilization was increased (18.9 ± 4 to 20.9 ± 4 ml/min, P &lt; 0.05). These findings are interpreted to indicate decreased myocardial ischemia in certain patients on perhexiline.
High Serum IgG4 Concentrations in Patients with Sclerosing Pancreatitis
Authors: Hideaki Hamano, Shigeyuki Kawa, Akira Horiuchi, Hiroshi Unno, Naoyuki Furuya, Taiji Akamatsu, Mana Fukushima, Toshio Nikaido, Kohzo Nakayama, Nobuteru Usuda, Kendo Kiyosawa
Journal: New England Journal of Medicine (2001)

Sclerosing pancreatitis is a unique form of pancreatitis that is characterized by irregular narrowing of the main pancreatic duct, lymphoplasmacytic inflammation of the pancreas, and hypergammaglobulinemia and that responds to glucocorticoid treatment. Preliminary studies suggested that serum IgG4 concentrations are elevated in this disease but not in other diseases of the pancreas or biliary tract.
THE RELATION OF HEMATIN TO PATHOLOGICAL PIGMENT FORMATION
Authors: Wade H. Brown
Journal: The Journal of Experimental Medicine (1911)

1. It has been shown that powdered hematin is exceedingly resistant to the metabolic action of tissue cells, and wherever injected it will remain for weeks with but slight and slowly progressing alteration. 2. The changes produced in hematin by tissue cells are identical with those changes resulting from the oxidation of hematin by hydrogen peroxid, forming a series of bodies of decreasing color intensity, which manifest an iron reaction in inverse proportion to their color. 3. These hemosideroid pigments are distinguished from true hemosiderin by the type of their iron reaction, by their solubility in dilute alkalies, and by their destructive oxidation by hydrogen peroxid. 4. Crystalline hematin injected into the tissues is subject to the same changes as powdered hematin. 3. Whereas powdered parahemosiderin is converted into hemosiderin by the tissue cells with comparative ease, powdered hematin shows no such conversion within forty-seven days, and as the only demonstrable change produced in hematin by the tissue cells does not result in the formation of either hemosiderin or hematoidin, the assumption that hematin is the progenitor of these pigments seems unwarranted.
PLASMA GALECTIN-3 ELEVATED IN PATIENTS WITH LONE PERSISTENT AND PAROXYSMAL ATRIAL FIBRILLATION AND ASSOCIATED WITH LEFT ATRIAL ENLARGEMENT
Authors: Xiao-Yan Wu, Rong Bai, Songnan Wen, Xin Du, Jianzeng Dong, Chang-Sheng Ma, Song-Nan Li
Journal: Journal of the American College of Cardiology (2014)
How Many Transplant Centers Do We Need?
Authors: Belding H. Scribner
Journal: JAMA (1973)

The publication of the 1973 kidney transplant registry report in this issue has very special importance because beginning last July 1, all of the costs of transplantation now are covered by Medicare. Among other things, the report indicates that approximately 1,300 transplants were performed in 1971. Although the 1972 figure undoubtedly will be higher, it will fall far short of the estimated 4,000 to 6,000 transplants that must be carried out annually to meet the projected need that is rapidly becoming apparent, since Medicare assumed a major funding responsibility for these patients. How should this need be met? Traditionally, American medicine has expanded its capability to meet a new health care need through self-generated programs sponsored either by individual physicians or local hospitals and clinics. In many expansion programs the free enterprise system continues to work well. However, in recent years this system has been getting American medicine deeper and
THE SPECIFICITY OF ALLERGIC REACTIONS
Authors: S. B. Salvin, R. F. Smith
Journal: The Journal of Experimental Medicine (1964)

Adult guinea pigs were made unresponsive to a heterologous protein (e.g. bovine gamma globulin, or BGG) or a hapten-protein conjugate (e.g. p-aminobenzoic acid-bovine gamma globulin, or PABAgammamiddot;BGG) by intraperitoneal injection of 80 mg cyclophosphamide and the specific antigen. This immunologic unresponsiveness developed to the specific antigen administered simultaneously with the cyclophosphamide, and not to any variants. Thus, animals unresponsive to PABAgammamiddot;BGG remained unresponsive to the original antigen on challenge with a variant, but formed delayed hypersensitivity and circulating antibody to the variant. The specificity of immunologic unresponsiveness, therefore, seems more closely related to the whole antigen molecule than does delayed hypersensitivity.
Diagnosis of invasive fungal infections by a real-time panfungal PCR assay in immunocompromised pediatric patients
Authors: C Landlinger, S Preuner, L Bašková, M van Grotel, N G Hartwig, M Dworzak, G Mann, A Attarbaschi, L Kager, C Peters, S Matthes-Martin, A Lawitschka, M M van den Heuvel-Eibrink, T Lion
Journal: Leukemia (2010)
Influenza vaccine effectiveness in Spain 2013/14: subtype-specific early estimates using the cycEVA study
Authors: S Jiménez-Jorge, F Pozo, S de Mateo, C Delgado-Sanz, I Casas, M García-Cenoz, J Castilla, R Sancho, L Etxebarriarteun-Aranzabal, C Quiñones, E Martínez, T Vega, A Garcia, J Giménez, J M Vanrell, D Castrillejo, A Larrauri
Journal: Eurosurveillance (2014)

Adjusted early estimates of the 2013/14 influenza vaccine effectiveness (VE) in Spain for all age groups was 35% (95% CI: ?9 to 62), 33% (95% CI: ?33 to 67) and 28% (95% CI: ?33 to 61) against any influenza virus type, A(H1N1)pdm09 and A(H3N2) viruses, respectively. For the population targeted for vaccination, the adjusted VE was 44% (95% CI: ?11 to 72), 36% (95% CI: ?64 to 75) and 42% (95% CI: ?29 to 74), respectively. These preliminary results in Spain suggest a suboptimal protective effect of the vaccine against circulating influenza viruses.
Activation of human B cells by phosphorothioate oligodeoxynucleotides.
Authors: H Liang, Y Nishioka, C F Reich, D S Pisetsky, P E Lipsky
Journal: Journal of Clinical Investigation (1996)

To investigate the potential of DNA to elicit immune responses in man, we examined the capacity of a variety of oligodeoxynucleotides (ODNs) to stimulate highly purified T cell-depleted human peripheral blood B cells. Among 47 ODNs of various sequences tested, 12 phosphorothioate oligodeoxynucleotides (sODNs) induced marked B cell proliferation and Ig production. IL-2 augmented both proliferation and production of IgM, IgG, and IgA, as well as IgM anti-DNA antibodies, but was not necessary for B cell stimulation. Similarly, T cells enhanced stimulation, but were not necessary for B cell activation. After stimulation with the active sODNs, more than 95% of B cells expressed CD25 and CD86. In addition, B cells stimulated with sODNs expressed all six of the major immunoglobulin VH gene families. These results indicate that the human B cell response to sODN is polyclonal. Active sODN coupled to Sepharose beads stimulated B cells as effectively as the free sODN, suggesting that stimulation resulted from engagement of surface receptors. These data indicate that sODNs can directly induce polyclonal activation of human B cells in a T cell-independent manner by engaging as yet unknown B cell surface receptors.
The Effect of a Recent Previous Visit to a Physician on Outcome After Childhood Bacterial Meningitis
Authors: Markku J. T. Kallio
Journal: JAMA (1994)

To assess the effect of a recent previous visit to a physician on the outcome of meningitis in children.Evaluation of data from children examined by a physician and sent home, either the previous day or 2 to 4 days before meningitis was diagnosed, and children whose meningitis was diagnosed at once. The patients were examined daily during hospitalization, neurologic examinations were repeated at 2 weeks and 3 and 6 months after discharge, and hearing was assessed 2 or more months after discharge.Eighteen pediatric hospitals in Finland from 1984 through 1991.A total of 325 children aged 3 months to 15 years with bacterial meningitis.Clinical and laboratory findings on admission, recovery during hospitalization, mortality, and neurologic abnormalities at 6 months of follow-up.In 74% of the patients, meningitis was diagnosed at once, 14% had visited a physician on the previous day, and 11% had seen a physician 2 to 4 days before diagnosis. The group seen 2 to 4 days earlier had a better level of consciousness, less frequent seizures, and more respiratory symptoms and otitis media than the other groups. The cerebrospinal fluid leukocyte count, white blood cell count, and erythrocyte sedimentation rate were highest and the cerebrospinal fluid glucose concentration was lowest in the children who had visited a physician 2 to 4 days earlier, although they also had lower cerebrospinal fluid protein and urine sodium and potassium levels. This group had the most rapid return to normal consciousness. There was no difference in the incidence of hearing impairment or neurologic sequelae. Even the mortality was virtually the same in the three groups: 4%, 4%, and 3% in the "same day," "previous day," and "2 to 4 days earlier" groups, respectively.Children who had visited a physician the previous day or 2 to 4 days before meningitis was diagnosed did not exhibit an increased frequency of hearing impairment, other neurologic abnormalities, or overall adverse outcome compared with children whose meningitis was diagnosed at once.
Ventricular Fibrillation
Authors: James N. Weiss, Peng-Sheng Chen, Zhilin Qu, Hrayr S. Karagueuzian, Alan Garfinkel
Journal: Circulation Research (2000)

Abstract —Combined experimental and theoretical developments have demonstrated that in addition to preexisting electrophysiological heterogeneities, cardiac electrical restitution properties contribute to breakup of reentrant wavefronts during cardiac fibrillation. Developing therapies that favorably alter electrical restitution properties have promise as a new paradigm for preventing fibrillation.
Liverpool CCG rethinks funding of homeopathy
Authors: Z. Kmietowicz
Journal: BMJ (2015)

Liverpool Clinical Commissioning Group has said that it is reconsidering whether to continue funding homeopathic treatments after a legal challenge from a pressure group that promotes rational thinking.

The Good Thinking Society, set up a year ago by the science writer Simon Singh, wrote to the group in February to highlight and challenge the group’s decision to approve spending on homeopathic treatments. The society said that it believed the decision to be unlawful and contrary to the best interests of local patients.

Commenting on the group’s agreement to reconsider its position on homeopathy, Singh said, “NHS spending is a major …
Soluble markers of inflammation are associated with Framingham scores in HIV-infected patients on suppressive antiretroviral therapy
Authors: María Guzmán-Fulgencio, Jose Medrano, Norma Rallón, Amaya Echeverria-Urabayen, Jose Miguel Benito, Clara Restrepo, Mónica García-Álvarez, Eugenia Vispo, Jesus San Roman, Carlos Sánchez-Piedra, Vicente Soriano, Salvador Resino
Journal: Journal of Infection (2011)
Sézary syndrome: Immunopathogenesis, literature review of therapeutic options, and recommendations for therapy by the United States Cutaneous Lymphoma Consortium (USCLC)
Authors: Elise A. Olsen, Alain H. Rook, John Zic, Youn Kim, Pierluigi Porcu, Christiane Querfeld, Gary Wood, Marie-France Demierre, Mark Pittelkow, Lynn D. Wilson, Lauren Pinter-Brown, Ranjana Advani, Sareeta Parker, Ellen J. Kim, Jacqueline M. Junkins-Hopkins, Francine Foss, Patrick Cacchio, Madeleine Duvic
Journal: Journal of the American Academy of Dermatology (2010)
Über die Bedeutung des Traumes in der Gruppentherapie
Authors: S. Betlheim
Journal: Psychotherapy and Psychosomatics (1958)

Research Articles| February 10 2010 Über die Bedeutung des Traumes in der Gruppentherapie Subject Area: Psychiatry and Psychology S. Betlheim S. Betlheim Aus der Neurologisch-Psychiatrischen Universitätsklinik, Zagreb Vorstand: Prof. Dr. R. Lopasic Search for other works by this author on: This Site PubMed Google Scholar Acta Psychotherapeutica et Psychosomatica (1958) 6 (1): 56–67. https://doi.org/10.1159/000285327 Article history Published Online: February 10 2010 Content Tools Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Facebook Twitter LinkedIn Email Tools Icon Tools Get Permissions Cite Icon Cite Search Site Citation S. Betlheim; Über die Bedeutung des Traumes in der Gruppentherapie. Acta Psychotherapeutica et Psychosomatica 1 January 1958; 6 (1): 56–67. https://doi.org/10.1159/000285327 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAll JournalsActa Psychotherapeutica et Psychosomatica Search Advanced Search Article PDF first page preview Close Modal This content is only available via PDF. 1958Copyright / Drug Dosage / DisclaimerCopyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher.Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. You do not currently have access to this content.
The spectrum of p53 mutations in colorectal adenomas differs from that in colorectal carcinomas
Authors: X. P. Hao, Ian Martin Frayling, J. G. Sgouros, M. Q. Du, T. C. Willcocks, I. C. Talbot, I. P. M. Tomlinson
Journal: Gut (2002)

<b>Background:</b> p53 mutations are frequently observed in colorectal carcinomas but they have also been found in colorectal adenomas, although considerably less frequently. <b>Aims:</b> To explore p53 mutations in benign tumours, we have screened 70 colorectal adenomas for allelic loss at, and point mutations in, TP53 by analysis of selected microdissected cell populations. <b>Results:</b> Sixteen (22.8%) adenomas were found to have allelic loss, of which 11 (15.7%) had p53 mutations. In adenomas with mild, moderate, or severe dysplasia, mutation or allelic loss occurred in 4.8%, 16.7%, and 52.6%, respectively (p&lt;0.001). Seven different mutations were found, all missense changes or inframe deletions: one (Thr150Arg) has not been found before while three (Gln144His, Gly245Arg, and Glu285Gln) have not been described previously in colorectal tumours. The other three mutations (Arg175Gly, ΔPro190, and Gly245Ser) have been found in colorectal carcinomas, the last commonly. Adenomas harboured a spectrum of p53 mutations which was significantly different from cancers as regards the position in the gene and a higher frequency of G→C/C→G changes. <b>Conclusions:</b> Combining our data on adenomas with data already published and in comparison with the spectrum of mutations in colorectal carcinomas, it is suggested that some p53 mutations have a weaker effect than others and are therefore more likely to be found in adenomas which have not progressed to carcinomas.
Case 30-1963
Authors: Allan L. Friedlich, Robert E. Scully
Journal: New England Journal of Medicine (1963)

Presentation of CaseA seventy-five-year-old housekeeper entered the hospital because of dyspnea and edema.The patient had had no complaints until eighteen months before entry, when she saw a physician because of edema of the legs, stasis ulcers and episodes of dyspnea. With digitalis, salt restriction, chlorothiazide and occasional injections of mercaptomerin (Thiomerin) there was transient clearing of the edema. The blood pressure at the onset of these symptoms was 200 systolic, 85 diastolic. The edema gradually reaccumulated, and a few weeks before admission orthopnea and paroxysmal nocturnal dyspnea developed. The urinary output decreased over a period of several weeks . . .