tbuckley/cabot-search huggingface dataset:
Clinical use of blade atrial septostomy.
Authors: S C Park, W H Neches, J R Zuberbuhler, C C Lenox, R A Mathews, F J Fricker, R A Zoltun
Journal: Circulation (1978)

A cardiac catheter enclosing an extensible blade was used to enlarge the interatrial opening in seven patients. Two patients with transposition of the great arteries who had balloon atrial septostomy as newborns subsequently presented with clinical evidence of a restrictive interatrial opening at 1 and 4 months of age. Cardiac catheterization confirmed restenosis of the interatrial opening and inadequate intracardiac mixing. After blade atrial septostomy the systemic arterial oxygen saturation increased by 20% and 30%, respectively. Five patients with mitral atresia complex, ages 2 months-9 1/2 years, had a restrictive interatrial communication and severe pulmonary venous hypertension (mean left atrial pressures ranged from 20-38 mm Hg). Following blade atrial septostomy, the pressure gradient between the atria was almost completely abolished and prompt clinical improvement was observed in each patient. All patients tolerated the procedure without complications. Blade atrial septostomy was a safe, effective procedure for enlarging the interatrial communication in this limited series of patients with an interatrial septum too thick to permit adequate rupture by conventional balloon atrial septostomy.
Making revalidation credible
Authors: Mike Pringle
Journal: BMJ (2005)

W ho wants revalidation? For a start patients do. They need to know that the doctor they consult is fit for what he or she claims to do. They want to know that their diabetologist is fit to be a diabetologist, their urologist fit to operate, their general practitioner fit for general practice. The idea that we get a lifetime licence to practise one year after medical school seems incredible to the public.

I, and many other doctors, want revalidation. I want to be able to show that I continue to be good enough to be a doctor and to know that my colleagues are all fit to practise. I want to see an end to the undermining of our profession through unacceptable standards eventually revealed through patient complaints.

A system of revalidation must identify poor performers and achieve two outcomes—protecting the public and supporting professionalism. If I am to put in the effort to be revalidated I want it to be time well spent. If we are to create …
Impaction and Fracture of a Video Capsule in the Small Bowel Requiring Laparotomy for Removal of the Capsule Fragments
Authors: L. C. Fry, G. De Petris, J. M. Swain, D. E. Fleischer
Journal: Endoscopy (2005)

Capsule endoscopy has become an important diagnostic tool because of its high sensitivity and specificity for evaluation of the small-bowel mucosa. It is usually a safe procedure. The main complication has been retention of the video capsule in patients with unsuspected obstructive small-bowel disease. We describe a case of a 76-year-old man who underwent capsule endoscopy for the investigation of chronic abdominal pain. The patient returned several months after the procedure with recurrence of his symptoms. Investigations at that time showed that the capsule had been retained in a section of the distal ileum which showed stricture formation and that it had broken up into fragments. This is the first reported case of a fractured video capsule.
Conservation of locus-specific microsatellite variability across species: a comparison of two Drosophila sibling species, D. melanogaster and D. simulans
Authors: B. Harr, B. Zangerl, G. Brem, C. Schlotterer
Journal: Molecular Biology and Evolution (1998)

Fifteen microsatellite loci were studied in Drosophila melanogaster and Drosophila simulans, two closely related sibling species which split 2-3.5 MYA. Within-species variances in repeat number were found to differ up to 1,000-fold among individual microsatellite loci. A significant correlation of log variances between both species indicated a locus-specific mutation rate of microsatellites. Hence, locus-specific effects are apparently among the major forces influencing microsatellite variation and deserve more consideration in microsatellite analysis.
627 GI-5005 IMMUNOTHERAPY PLUS PEG-IFN/RIBAVIRIN VERSUS PEG-IFN/RIBAVIRIN IN GENOTYPE 1 CHRONIC HCV SUBJECTS; PRELIMINARY PHASE 2 EVR ANALYSES
Authors: E.J. Lawitz, T.D. Boyer, G.T. Everson, I.M. Jacobson, W. Lee, J.G. McHutchison, P.J. Pockros, M.L. Shiffman, J.M. Vierling, S. Cruickshank, T.C. Rodell, D. Apelian
Journal: Journal of Hepatology (2009)
Intra-articular steroids.
Authors: S Santavirta, A U Arstila, T Sorvari
Journal: BMJ (1978)

could be evaluated as even better.As the possibility for iatrogenic damage after intra- articular cortisone injections has been reported2-'i to be higher than was observed after intra-articular or especially intra- muscular glycosaminoglycan polysulphate therapy it seems justified to suggest this treatment in cases of painful knee joints after sports trauma and strenuous exercise.
NEURASTHENIA.Read before the St. Louis Medical Society, Jan. 20, 1894.
Authors: I. N. LOVE
Journal: JAMA (1894)

Since Beard's time, the well-posted physician, whether in the general field or a special line, has recognized neurasthenia "as a legitimate and well circumscribed morbid entity." Our own Dr. C. H. Hughes, of St. Louis, recognized the world over as a high authority upon neurological subjects, in a paper read before the Missouri State Medical Association fully twelve years ago, suggested as a name for the disease, general functional neurotrophia as preferaable to neurasthenia. He expressed the thought at the time that the disease was a more or less general failure of the normal nutrition appropriating power in the higher nerve centers, especially the psychical, leading to consequences short of appreciable structural change—a pure neurotrophia—which is only functional in its effects and confined, in expression, to an altered and lowered functionation in the nervous system itself. A synonym for the disease is nervous prostration, and the name which Beard himself
Supply Problem With Inactivated Poliovirus Vaccine Resolved
Authors: Stuart L. Nightingale
Journal: JAMA (1994)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
CASE OF INTESTINAL OBSTRUCTION SUCCESSFULLY TREATED BY THE PASSAGE OF AN ELASTIC TUBE
Authors: H. G. Trend
Journal: BMJ (1854)

eduction was discontinued As the symptom' were not v urgent, andasit was doubtful whether the obstruction wucaused by stngulated intestine, wresolved to wait until morning.Two gmins of calomel and one and a half of opium were ordered to be given every three hours, and cold applications to be constantly applied during the night.Oct. 14th.There was no evacuation.The other symptoms were the same, the tumour onrly being rather more tender.It was then decided to cut down to the ring, and, if necessary, to enlarge it.In a minute, I was enabled to place my finger in the ring, which very tightly embraced an omental pro- trusion.The stricture was divided; and immediately, from under the omental mass, was heard a gurgling sound, as if intestine was slipping back into the abdominal cavity.U0pon examining the sac, it was found to contain nothing but omentum, which had formed extensive and firm adhe- sion, and could not be returned.The patient expressed himself much relieved; and in the evening, although the bowels had not been moved, all pain and tenderness had disappeared.Oct. 15th.There had been no evacuation, but still no pain.Calomel and small doses of opium every three hours, and frequent injections, were given.Oct. 16th.No evacuation of the bowels had occurred; but the vomiting, which had abated after the operation, now returned with great violence.The injections were directed to be continued; and one drop of croton oil with three grains of jalap, in the form of a pill, was gi'Ven every three or four hours.Oct. 17th.There was no improvement; everything, both food and medicine, was rejected.Not seeing, much advantage in such a case from medicine, and fearing to excite inflamma- tion by persisting in the use of strong purgatives, we deter- mined in some degree to leave the case to nature, and merely ordered an occasional injection, and a drachm of sulphate of magnesia in infusion of roses three times a day.Oct. 18th.There was no change.Oct. 19th.At 9 A.M. the bowels were freely moved; and during the day he had several other motions.Oct. 20th.The patient was improving; but, sickness still continuing, a saline effervescing mixture was given.From this period to the 29th, he slowly improved; and, on that day, we fotud our patient down stairs, with a clean tongue, open bowels, and a moderately good appetite.RnEMArE1s.The above appears to be an interesting case.The result proved the propriety of the operation; but, even if no strictured intestine had been found, I think, under such circumstances, the operation would have becn justifiable.The obstruction was no doubt originally caused by a small
Combinatorial Roles of Olig2 and Neurogenin2 in the Coordinated Induction of Pan-Neuronal and Subtype-Specific Properties of Motoneurons
Authors: Rumiko Mizuguchi, Michiya Sugimori, Hirohide Takebayashi, Hidetaka Kosako, Motoshi Nagao, Shosei Yoshida, Yo-ichi Nabeshima, Kenji Shimamura, Masato Nakafuku
Journal: Neuron (2001)
Annular erythema: A possible association with primary Sjögren's syndrome
Authors: Noriko Teramoto, Ichiro Katayama, Harue Arai, Hikaru Eto, Kimio Kamimura, Mari Uetsuka, Shigeo Kondo, Kiyoshi Nishioka, Shigeo Nishiyama
Journal: Journal of the American Academy of Dermatology (1989)
Bicycle helmets: it's time to use them
Authors: F. P Rivara
Journal: BMJ (2000)

The evidence that they reduce head injuries is too strong to ignore 

Papers p 1055 

Bicycling is a worldwide activity. In both developed and developing countries it serves as an important means of transportation as well as an enjoyable recreational activity for adults and children. Thus, injuries related to bicycling are comparatively common, and head injuries account for one third of visits to emergency departments, up to two thirds of hospitalisations, and three quarters of deaths.1 Head injuries also carry a substantial risk of long term disability. Thus, preventing head injuries associated with this common, worldwide activity is important.

Safety helmets for bicycling have been available for at least 20 years. Although randomised controlled trials have become the gold standard for providing evidence of the effectiveness of clinical interventions, these trials are not feasible for examining whether helmets prevent head injuries. Given that the rate of head injury is about 20 injuries per 100 000 people, a randomised controlled trial would need to involve tens …
15-deoxy-δ12,14-prostaglandin J2 induces apoptosis in human myofibroblasts by a pathway unrelated to peroxysome-proliferator-activated receptors, involving reactive oxygen species
Authors: L. Li, J. Tao, J. Davaille, A. Mallat, J. Rieusset, H. Vidal, S. Lotersztajn
Journal: Journal of Hepatology (2001)
Low Doses of Bisphenol A and Diethylstilbestrol Impair Ca <sup>2+</sup> Signals in Pancreatic α-Cells through a Nonclassical Membrane Estrogen Receptor within Intact Islets of Langerhans
Authors: Paloma Alonso-Magdalena, Ouahiba Laribi, Ana B. Ropero, Esther Fuentes, Cristina Ripoll, Bernat Soria, Angel Nadal
Journal: Environmental Health Perspectives (2005)

Glucagon, secreted from pancreatic alpha-cells integrated within the islets of Langerhans, is involved in the regulation of glucose metabolism by enhancing the synthesis and mobilization of glucose in the liver. In addition, it has other extrahepatic effects ranging from lipolysis in adipose tissue to the control of satiety in the central nervous system. In this article, we show that the endocrine disruptors bisphenol A (BPA) and diethylstilbestrol (DES), at a concentration of 10(-9) M, suppressed low-glucose-induced intracellular calcium ion ([Ca2+]i) oscillations in alpha-cells, the signal that triggers glucagon secretion. This action has a rapid onset, and it is reproduced by the impermeable molecule estradiol (E2) conjugated to horseradish peroxidase (E-HRP). Competition studies using E-HRP binding in immunocytochemically identified alpha-cells indicate that 17beta-E2, BPA, and DES share a common membrane-binding site whose pharmacologic profile differs from the classical ER. The effects triggered by BPA, DES, and E2 are blocked by the G alpha i- and G alpha o-protein inhibitor pertussis toxin, by the guanylate cyclase-specific inhibitor 1H-[1,2,4]oxadiazolo[4,3-a]quinoxalin-1-one, and by the nitric oxide synthase inhibitor N-nitro-L-arginine methyl ester. The effects are reproduced by 8-bromo-guanosine 3',5'-cyclic monophosphate and suppressed in the presence of the cGMP-dependent protein kinase inhibitor KT-5823. The action of E2, BPA, and DES in pancreatic alpha-cells may explain some of the effects elicited by endocrine disruptors in the metabolism of glucose and lipid.
Parasite antigen-specific human T cell lines and clones. Major histocompatibility complex restriction and B cell helper function.
Authors: T B Nutman, E A Ottesen, A S Fauci, D J Volkman
Journal: Journal of Clinical Investigation (1984)

The development of T lymphocyte lines and clones of defined specificity has become an important method for investigating both T cell recognition of foreign antigens as well as T cell influence on B cells. In the present study, human antigen-specific T cell lines and clones have been derived from a patient with a naturally acquired filarial infection. These T cells are of the helper phenotype (Leu 1+, Leu 2-, Leu 3+) and are independent of exogenous interleukin-2. Furthermore, these T cells have been shown to require both antigen-presenting cells and antigen for optimal proliferation. Helper function mediated by these T cells as manifested by the in vitro induction of parasite-specific antibody was antigen-dose dependent, requiring much lower antigen concentrations than those necessary to induce blastogenesis. More importantly, there is an absolute requirement of the T cell line for HLA-DR histocompatible antigen-presenting cells; clones derived from this T cell line show a more specific DR-related restriction--to only one of the two parental DR haplotypes in antigen stimulated proliferative responses. Such parasite antigen specific human helper T cell lines and clones should prove useful in exploring the fine control of the host response to naturally acquired helminth infections. In addition, these long-term T cell lines and clones can provide a potent tool for examining not only the events involved in human T cell responses to parasite antigens, but also into the associated cellular and humoral factors necessary for the B cell responses which follow.
The polymeric immunoglobulin receptor is the major calmodulin-binding protein in an endosome fraction from rat liver enriched in recycling receptors
Authors: C Enrich, S Jäckle, R J Havel
Journal: Hepatology (1996)

Rat liver endosomes contain one major high–affinity calmodulin–binding protein (CaMBP) that now has been identified as the polymeric immunoglobulin receptor (pIgR). In isolated endosomes pIgR was enriched in the receptor–recycling compartment (RRC); lesser enrichment was found in ‘early' endosome (CURL) and much less in ‘late' endosome fractions (multivesicular bodies, MVB). The distribution of the major CaMBP, shown by Western blotting or by overlay with I125–calmodulin in the isolated fractions, was consistent with rapid accumulation of I125–immunoglobulin A (IgA) in RRC and CURL after intravenous injection into rats. The receptor was also found in sinusoidal plasma membranes but not in cell fractions containing apical (bile canalicular) or lateral plasma membrane domains of the hepatocyte. The interaction of pIgR with calmodulin was shown by direct binding assays and by affinity chromatography. Thus, calmodulin is the first cytoplasmic protein shown to interact with the pIgR. We postulate that calmodulin regulates pIgA trafficking in rat liver. In addition, the receptor recycling fraction emerges as an endosomal subcompartment involved in pIgA transport via pIgR.
Lung biopsy in the diagnosis of diffuse lung disease.
Authors: J G Scadding
Journal: BMJ (1970)

This lecture commemorates Arthur Tudor Edwards, one of the very small group of surgeons who, in the decade following the first world war, established the surgery of intrathoracic organs as a practicable procedure.For one year, 1932-3, I was house officer at the Brompton Hospital to him and his colleague, J. E. H. Roberts, the two leading thoracic surgeons in London.Seeking a possible link between the time when as a young man I was privileged to work for Tudor Edwards and my present interest in the nosology of broncho-pulinonary disease, I propose in this lecture to consider the contribution of surgical biopsy to the diagnosis of widespread lung disease.Extrinsic allergic alveolitis ... 1 Sarcoidosis ...15 Eosinophilic granuloma (histiocytosis X) 5 Malignant disease..4Prinmary emphysema... 1 Categorization doubtful... 8 Alveolar fibrosis (? extrinsic allergic, ?cryptogenic) 3 Necrobiotic nodules .. .4 No evidence of rheumatoid arthritis 3 Later developed rheumatoid arthritis 1 Honeycomb lung, unclassifiable .. . 1 Biopsy not contributory. . . 5 Final diagnosis (after further observation): Probable cryptogenic fibrosing alveolitis (1 with coal miner's pneumoconiosis) . . 3Gas transfer defect of undetermined cause: death from
INFECTED MYOMA COMPLICATING PREGNANCY: CAESAREAN SECTION FOLLOWED BY TOTAL ABDOMINAL HYSTERECTOMY
Authors: H. R. Spencer
Journal: BMJ (1925)

THE case here recorded is published to complete my series of Caesarean sections followed by hysterectomy for myoma.In this case the tumour could have been removed easily by myomectomy, but the infection of the tumour would have X rendered myomectomy or simple Caesarean section a dangerous operation.
Lupus erythematosus tumidus is a separate subtype of cutaneous lupus erythematosus
Authors: V. Schmitt, A.M. Meuth, S. Amler, E. Kuehn, M. Haust, G. Messer, V. Bekou, C. Sauerland, D. Metze, W. Köpcke, G. Bonsmann, A. Kuhn
Journal: British Journal of Dermatology (2009)

Journal Article Lupus erythematosus tumidus is a separate subtype of cutaneous lupus erythematosus Get access V. Schmitt, V. Schmitt Department of Dermatology Search for other works by this author on: Oxford Academic Google Scholar A.M. Meuth, A.M. Meuth Department of Dermatology Search for other works by this author on: Oxford Academic Google Scholar S. Amler, S. Amler Department of Medical Informatics and Biomathematics, University of Münster, 48149 Münster, Germany Search for other works by this author on: Oxford Academic Google Scholar E. Kuehn, E. Kuehn Department of Dermatology Search for other works by this author on: Oxford Academic Google Scholar M. Haust, M. Haust Department of Dermatology, University of Düsseldorf, Düsseldorf, Germany Search for other works by this author on: Oxford Academic Google Scholar G. Messer, G. Messer Department of Dermatology, Ludwig Maximilians University, Munich, Germany Search for other works by this author on: Oxford Academic Google Scholar V. Bekou, V. Bekou Department of Dermatology, Ludwig Maximilians University, Munich, Germany Search for other works by this author on: Oxford Academic Google Scholar C. Sauerland, C. Sauerland Department of Medical Informatics and Biomathematics, University of Münster, 48149 Münster, Germany Search for other works by this author on: Oxford Academic Google Scholar D. Metze, D. Metze Department of Dermatology Search for other works by this author on: Oxford Academic Google Scholar W. Köpcke, W. Köpcke Department of Medical Informatics and Biomathematics, University of Münster, 48149 Münster, Germany Search for other works by this author on: Oxford Academic Google Scholar ... Show more G. Bonsmann, G. Bonsmann Department of Dermatology Search for other works by this author on: Oxford Academic Google Scholar A. Kuhn A. Kuhn Department of Dermatology Annegret Kuhn. E‐mail: kuhnan@uni‐muenster.de Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 162, Issue 1, 1 January 2010, Pages 64–73, https://doi.org/10.1111/j.1365-2133.2009.09401.x Published: 01 January 2010
Necrotizing Vasculitis After Acute Serous Otitis Media
Authors: JOHN S. SERGENT
Journal: Annals of Internal Medicine (1974)

Seven adult patients developed widespread necrotizing vasculitis after acute serous otitis media. Clinically, these patients resembled other patients with vasculitis—neurological signs, renal disease, and systemic symptoms were the dominating clinical features. But significant hypertension, eosinophilia, and asthma were not seen in these patients, and none carried the hepatitis B antigen. Four of the seven patients developed acute episcleritis. Although the etiology is unclear, these clinical and epidemiological relations suggest that these patients form a distinct entity and that our concepts of necrotizing vasculitis should be broadened.
Hearing loss leading to impaired ability to communicate in residents of homes for the elderly.
Authors: J. K. Anand, I. Court
Journal: BMJ (1989)

Altogether 304 of 316 residents of eight homes in Peterborough were assessed informally by IC, a specialist teacher experimented in the rehabilitation of adults with acquired loss, in an attempt to identify and ameliorate hearing loss that leads to an impair ability to communicate
Treatment of Advanced Squamous Cell Carcinoma of the Skin with Isotretinoin
Authors: SCOTT M. LIPPMAN
Journal: Annals of Internal Medicine (1987)

To determine the efficacy of oral isotretinoin in refractory advanced squamous cell carcinoma of the skin.Case series trial.Tertiary care center at a university hospital.A consecutive collection of four patients with advanced squamous cell carcinoma of the skin who failed to respond to standard surgical or radiation therapy.Isotretinoin in gelatin capsules was given at a total daily dose of 1 mg/kg body weight in two divided doses for at least 4 weeks.Bidimensional tumor measurements at monthly intervals showed striking responses to isotretinoin in all four patients. Response durations ranged from 2 to more than 23 months. The drug produced reversible moderate mucocutaneous side effects and asymptomatic laboratory abnormalities.Impressive responses to isotretinoin occurred in our four patients and in six of ten other reported patients. Retinoic acid's mechanisms of action in cutaneous squamous cell carcinoma is not precisely known, but may involve the modulation of epidermal growth factor receptors and certain protein kinases. These in-vitro findings and the clinical data suggest that retinoids may be an effective and well-tolerated therapy for refractory advanced squamous cell carcinoma of the skin. The absence of any other effective systemic therapy indicates the need for continuing trials with retinoids in this disease.