HISTOPLASMOSIS: REPORT OF A CASE
Authors: Robert H. Williams, William J. Cromartie
Journal: Annals of Internal Medicine (1940)

Case Reports1 May 1940HISTOPLASMOSIS: REPORT OF A CASEROBERT H. WILLIAMS, M.D., WILLIAM J. CROMARTIE, M.D.ROBERT H. WILLIAMS, M.D.Search for more papers by this author, WILLIAM J. CROMARTIE, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-13-11-2166 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe fungus infection now known as histoplasmosis, and its causative agent, the Histoplasma capsulatum, were first described by Darling in 1906 and 1908.1, 2 He reported three cases. Since then, single cases of histoplasmosis have been reported by Riley and Watson,3 Phelps and Mallory,4 Crumrine and Kessell,5 and Dodd and Tompkins.6The disease is manifested clinically by moderate fever, emaciation, splenomegaly, hepatomegaly, enlargement of lymph nodes, leukopenia and slight anemia. In only one of the seven cases recorded was an accurate diagnosis made antemortem. Dodd and Tompkins recognized the parasite in the large mononuclear cells (monocytes) of the blood of...Bibliography1. DARLING ST: A protozoon general infection producing pseudotubercles in the lungs and focal necrosis in the liver, spleen and lymph nodes, Jr. Am. Med. Assoc., 1906, xlvi, 1283. CrossrefGoogle Scholar2. DARLING ST: Histoplasmosis: A fatal infectious disease resembling Kala-Azar found among natives of Tropical America, Arch. Int. Med., 1908, ii, 107. CrossrefGoogle Scholar3. RILEYWATSON WACJ: Histoplasmosis of Darling, with report of a case originating in Minnesota, Am. Jr. Trop. Med., 1926, vi, 271. CrossrefGoogle Scholar4. PHELPSMALLORY BMFB: Toxic cirrhosis and primary liver cell carcinoma complicated by histoplasmosis of the lung, United Fruit Company, Medical Department, Fifteenth Annual Report, pp. 115-122, 1926. Google Scholar5. CRUMRINEKESSELL RMJF: Histoplasmosis (Darling) without splenomegaly, Am. Jr. Trop. Med., 1931, xi, 435. CrossrefGoogle Scholar6. DODDTOMPKINS KEH: A case of histoplasmosis of Darling in an infant, Am. Jr. Trop. Med., 1934, xiv, 127. CrossrefGoogle Scholar7. ROCHA-LIMA HD: Beitrag zur Kenntnis der Blastomykosen. Lymphangitis epizootica und Histoplasmosis, Centralbl. f. Bakt., Abt. I, Orig., 1912, lxvii, 233. Google Scholar8. DEMONBREUN WA: The cultivation and cultural characteristics of Darling's Histoplasma capsulatum , Am. Jr. Trop. Med., 1934, xiv, 93. CrossrefGoogle Scholar9. CIFERRIREDAELLI RP: Histoplasma capsulatum Darling, the agent of "Histoplasmosis": Systematic position and characteristics, Jr. Trop. Med. and Hyg., 1934, xxxvii, 278. Google Scholar10. DEMONBREUN WA: The dog as a natural host for Histoplasma capsulatum , Am. Jr. Trop. Med., 1939, xix, 565. CrossrefGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Nashville, Tennessee*Received for publication June 10, 1939.From the Department of Medicine and the Department of Pathology, Vanderbilt University School of Medicine, Nashville, Tennessee. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byHistoplasmosis in immunosuppressed patientsHistoplasmosisUNUSUAL ETIOLOGIES OF PORTAL SYSTEM HYPERTENSION (TORULOSIS, PHLEBOSCLEROSIS AND RETROPERITONEAL CHRONIC INFLAMMATION)*MATTHEW TAUBENHAUS, M.D., F.A.C.P., ORMAND C. JULIAN, M.D., F.A.C.S., JAKUB SCHLICHTER, M.D., MARGARET LITTMAN, M.D.Die MykosenOral Manifestations of HistoplasmosisHistoplasmosis 1 May 1940Volume 13, Issue 11Page: 2166-2171KeywordsAnemiaBlood cellsCellsFeversHepatomegalyHistoplasma capsulatumHistoplasmosisLymph nodesMonocytesSplenomegaly ePublished: 1 December 2008 Issue Published: 1 May 1940 PDF downloadLoading ...