tbuckley/cabot-search huggingface dataset:
Drug points: Metabolic decompensation in pump users due to lispro insulin precipitation
Authors: H. A Wolpert
Journal: BMJ (2002)

52.0% of women in the medium and high severity categories, respectively. CommentsLegalisation of abortion in South Africa immediately decreased morbidity but the magnitude was not substantial, possibly because morbidity was already lower than in many countries.The lack of change may reflect additional covert induced abortion activity, perhaps through the use of misoprostol in unregistered settings.There has been a trend towards lower technology.While more manual vacuum aspiration and less general anaesthetic and blood transfusion is commendable, antibiotic use and pain relief seem inadequate.The trend towards lower technology partially reflects success of training programmes for induced abortion; however, our findings suggest that further structured training in the use of manual vacuum aspiration with paracervical block and appropriate use of antibiotics and misoprostol would be beneficial.
The Lumbar Spine and Back Pain.
Authors: Malcolm I. V. Jayson
Journal: Annals of Internal Medicine (1976)

Evolution of the Lumbar Spine and Back Pain. Age-Related and Degenerative Pathology of Interverterbral Discs and Apophyseal Joints. Basic Neurophysiological Mechanisms of Pain and Pain Therapy. The Sources of Low Back Pain. Pathogenesis of Nerve Root Damage. Vascular Damage Fibrosis and Chronic Inflammation in Low Back Pain and Sciatica. Biochemistry Studies of the Intervertebral Disc. Biomechanical Studies in Cadaveric Spines. Lumbar Mechanics as Revealed By Lumbar Intradiscal Pressure Measurements. Measurement of Spinal Movement and Function. Radiological Investigation of Mechanical Back Pain. Magnetic Resonance Imaging. Syndromes of Back Pain and Their Classification. Facet Joint Syndrome. Isolated Disc Resorption. Spinal Stenosis of the Central and Root Canal. Lumbar Spine Instability. Tumours of the Lumbar Spine. Spinal Deformities. Conservative Treatment of Back Pain. Back Schools. Surgery. An Overview. The Failed Back. Chemonucleolysis. Understanding the Patient with Backache. Psychological Treatment. Psychiatric Factors in Back Pain. The Functional Restoration Programme for Postoperative and Chronic Low Back Pain Patient. Epidemiology of Low Back Pain. Prevention of Back Pain in Industry. Osteoporosis and Metabolic Bone Disease. Pain and Tender Points: Fibrositis, Fibromyalgia, And Related Syndromes. Back Pain in Children. Index
Abstract 9213: Risk of Gastrointestinal Conditions Among Patients with Atrial Fibrillation
Authors: François Laliberté, Yuliya Moore, Katherine Dea, Joyce C LaMori, Samir H Mody, JaCinda L Jones, Michelle D Arledge, C V Damaraju, Mei Sheng Duh, Jeff R Schein, Patrick Lefebvre
Journal: Circulation (2011)

Objective: There are limited data suggesting that gastrointestinal (GI) conditions are common in patients with atrial fibrillation (AF). However, AF patients are generally older, and, many agents utilized by patients with AF are known to increase the risk of GI events. The objective of this study was to describe the risk of GI events among patients with AF. Design: An analysis of insurance healthcare claims from the Thomson Reuters MarketScan ® database was conducted. Over the period from 2005 to 2009, all subjects aged ≥18 years as of the date of first AF diagnosis, with ≥180 days of continuous insurance coverage prior to the index AF and no GI event within 180 days of the index AF were selected. GI events were identified from claims with a primary or secondary diagnosis code for any GI condition and for the subset of GI conditions consistent with dyspepsia (upper abdominal pain, abdominal pain, abdominal discomfort and dyspepsia). The risk of GI events was assessed with incidence rates (IRs) (new GI cases / patient-years of observation). Subgroup analyses were performed with respect to gender, age and CHADS 2 score. Results: A total of 413,168 patients with AF and no GI event in the 180-day baseline period were identified. The mean (median; SD) age of all patients with AF was 67.7 years (69; 15); 43% were female. During follow-up (mean of 563 days), IRs of any GI event and dyspepsia for patients with AF but no GI symptoms at baseline were 38.8 and 14.7 events per 100 patient-years. Corresponding IRs of any GI events for female and male were 43.6 and 35.5; for patients in the age groups below 65, 65-74, 75-84 and ≥85 years IRs were 32.3, 38.9, 44.6 and 52.7; for patients with CHADS 2 score of 0, 1-2, 3-4 and 5-6 IRs were 30.3, 41.6, 56.9 and 74.5, respectively. At baseline, 257,357 patients (62%) had at least one medication dispensed which may cause GI tolerability issues. Conclusions: In this large claims database, AF was associated with a high IR of GI events. A rising trend in IR was observed with increasing age and CHADS 2 score. Higher propensity for GI events (such as dyspepsia) and agents that selectively cause higher symptomatic GI rates may relate to poor medication adherence in AF patients. Therefore, prescribers should take subgroup characteristics of this population into consideration.
Prevalence and clinical impact of <scp>QRS</scp> duration in patients with low‐flow/low‐gradient aortic stenosis due to left ventricular systolic dysfunction
Authors: Frédéric A. Sebag, Nicolas Lellouche, Najia Chaachoui, Jean‐Luc Dubois‐Rande, Pascal Gueret, Jean‐Luc Monin
Journal: European Journal of Heart Failure (2014)
A memorable interview: Experience not required
Authors: J. S M Zorab
Journal: BMJ (2000)

It was 1957, and I had just completed my preregistration year. The plan was for me to join my eldest brother in general practice, but he insisted that I first did a six month obstetric post. I applied for various posts and was interviewed here and there, all without success. In due course I applied and was interviewed for a post at what was then Paddington General Hospital in the Harrow Road. I …
Abstract 11089: Constitutive SIRT1 Overexpression Impairs Mitochondrial Function in Mice
Authors: Tsuneaki Kawashima, Yasutaka Inuzuka, Junji Okuda, Takao Kato, Shinichiro Niizuma, Yodo Tamaki, Michiko Narazaki, Tetsuya Matsuda, Souichi Adachi, Genzou Takemura, Toru Kita, Takeshi Kimura, Tetsuo Shioi
Journal: Circulation (2010)
Epidemiology of panic disorder in African-Americans
Authors: E Horwath, J Johnson, C D Hornig
Journal: American Journal of Psychiatry (1993)

The authors investigated the prevalence and clinical characteristics of panic disorder among African-Americans and whites in a community study.A total of 4,287 African-American and 12,142 white subjects were interviewed at five sites as part of the Epidemiologic Catchment Area study. Panic disorder and other diagnoses were made using the National Institute of Mental Health Diagnostic Interview Schedule and DSM-III criteria.The lifetime prevalence of panic disorder was 1.2% among African-Americans and 1.4% among whites, a nonsignificant difference. Comparisons between African-Americans and whites on age at onset, years with panic disorder, and suicide attempts revealed no significant differences. Rates of individual panic symptoms in African-American and white subjects with panic disorder were similar, although African-Americans reported a higher mean number of symptoms during their worst episode. Among subjects with comorbid panic disorder, African-Americans and whites had similar rates of major depression, alcohol abuse, drug abuse, obsessive-compulsive disorder, agoraphobia, somatization disorder, and schizophrenia. Patterns of treatment seeking among African-American and white panic subjects were similar, with the exception that African-Americans were significantly less likely to seek help from a mental health professional in private practice.On the basis of these findings, the authors conclude that panic disorder in the community is similar among African-Americans and whites with respect to lifetime prevalence, age at onset, years of disorder, symptom distribution, suicide attempts, and comorbidity with other psychiatric disorders. Differences in the diagnosis and treatment of panic disorder by race are not due to differences in the prevalence or nature of the disorder.
Abstract 3991: Increased expression of cancer stem cells markers (CD44, CD90 and CD133) contributes to disease progression and reduced survival in hepatoblastoma patients from Egypt: four years survival data
Authors: Abdel-Rahman N. Zekri, Abeer A. Bahnassy, Mohamed Fawzy, Mohamed El-Wakil, Ahmed Abdel-Sayed, Marwa E. Sheta
Journal: Cancer Research (2014)

Abstract Background: Hepatoblastoma (HB) is an embryonal tumor of the liver that occurs in infants and young children. Complete surgical resection and cisplatin-containing chemotherapy are crucial for cure in HB. Cancer stem cells (CSCs) constitute a newly identified subpopulation, which may differentiate into heterogeneous progenies of malignant cells. The aim of this study is to assess the prognostic and predictive values of CSCs markers (CD133, CD90 and CD44) in a cohort of HB patients from Egypt. Methods: Disease status was evaluated for 43 HB patients at the main checkpoints of therapy and during follow-up. Protein and RNA expressions of CD44, CD 90 and CD 133 were assessed by immunohistochemistry and quantitative real time (qPCR). Results: OS for all patients at 4 years was 58.2. OS significantly correlated with disease stages (stage I&amp;II versus III&amp;IV 81.9% and 30%, p&amp;lt;0.001); tumor response (p&amp;lt;0.001); CD44, CD 90, CD 133 expression (p&amp;lt;0.001) versus treatment modality (total surgical resection versus incomplete or no resection, 83.8% versus 25.2 %; p&amp;lt;0.001). Reduced DFS was associated with CD44 and CD133 expression (p&amp;lt;0.001) only. Conclusion: Complete surgical resection and systemic chemotherapy significantly improve outcome in HB with a significantly higher survival rates among patients with early stage disease. Expression of CSCs markers (CD133, 44, and 90) can predict poor outcome in HB patients with reduced OS and DFS rates. However further studies are required to confirm their prognostic and potential targeted therapy value. Citation Format: Abdel-Rahman N. Zekri, Abeer A. Bahnassy, Mohamed Fawzy, Mohamed El-Wakil, Ahmed Abdel-Sayed, Marwa E. Sheta. Increased expression of cancer stem cells markers (CD44, CD90 and CD133) contributes to disease progression and reduced survival in hepatoblastoma patients from Egypt: four years survival data. [abstract]. In: Proceedings of the 105th Annual Meeting of the American Association for Cancer Research; 2014 Apr 5-9; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2014;74(19 Suppl):Abstract nr 3991. doi:10.1158/1538-7445.AM2014-3991
Prognostic Value of Cardiac Troponin T After Noncardiac Surgery: 6-Month Follow-Up Data 11All editorial decisions for this article, including selection of referees, were made by a Guest Editor. This policy applies to all articles with authors from the University of California San Francisco.
Authors: Francisco Lopez-Jimenez, Lee Goldman, David B Sacks, Eric J Thomas, Paula A Johnson, E.Francis Cook, Thomas H Lee
Journal: Journal of the American College of Cardiology (1997)
Comparison of Sulfur Hexafluoride Microbubble (SonoVue)-Enhanced Myocardial Contrast Echocardiography With Gated Single-Photon Emission Computed Tomography for Detection of Significant Coronary Artery Disease
Authors: Roxy Senior, Antonella Moreo, Nicola Gaibazzi, Luciano Agati, Klaus Tiemann, Bharati Shivalkar, Stephan von Bardeleben, Leonarda Galiuto, Hervé Lardoux, Giuseppe Trocino, Ignasi Carrió, Dominique Le Guludec, Gianmario Sambuceti, Harald Becher, Paolo Colonna, Folkert ten Cate, Ezio Bramucci, Ariel Cohen, Gianpaolo Bezante, Costantina Aggeli, Jaroslaw D. Kasprzak
Journal: Journal of the American College of Cardiology (2013)
Tuberculosis in the EU and EEA/EFTA countries - what is the latest data telling us?
Authors: V Hollo, A Amato-Gauci, C Ködmön, D Manissero
Journal: Eurosurveillance (2009)

Since 1 January 2008, the European Centre for Disease Prevention and Control (ECDC) and the World Health Organization Regional Office for Europe (WHO/Europe) jointly coordinate the tuberculosis (TB) surveillance activities in Europe. The data collected provides an opportunity for a comprehensive analysis of the TB situation. We aimed at analysing the EU and EEA/EFTA data to identify general TB trends and to provoke some discussion regarding the challenges and needs for monitoring the epidemic.
THE LEUKOCYTE COUNT IN PRIMARY ATYPICAL PNEUMONIA OF UNDETERMINED ETIOLOGY
Authors: Ovid O. Meyer, Ethel W. Thewlis
Journal: Annals of Internal Medicine (1944)

ExcerptBronchopneumonia of the type now commonly considered to be virus pneumonia was seen as long ago as 1872,1but present day attention was directed to it by much later reports, chiefly those of Gallagher,2Bowen,3Reimann,4Kneeland and Smetana,5and Longcope.6In recent years, probably because of greatly increased incidence and, to a lesser extent, proper recognition of this condition and the more positive exclusion of pneumonias of other types by detailed bacteriologic study, these atypical pneumonias have been very frequently observed. In the past six years more than a hundred reports relating to this condition have appeared in the...
A Memory Rising
Authors: Charles R. Feldstein
Journal: JAMA (2003)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Journals JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2024 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Silent Myocardial Ischemia and Infarction.
Authors: Peter F. Cohn
Journal: Annals of Internal Medicine (1986)

would be needed to do the re- search if the funds were avail- able.The book ends with the con- clusion that universal medical and hospital insurance is a pre- requisite to a broad range of accessible and affordable LTC services, a conclusion that makes the transfer of Canadian LTC ex- perience to the United States a difficult task.
Abstract 13375: Quantitative Analysis of Narrow QRS Peaks Predicts Ventricular Arrhythmic Events in Patients With Hypertrophic Cardiomyopathy
Authors: Adrian M Suszko, Karthik Viswanathan, Danna A Spears, Nicholas M Jackson, Gavin E Jones, Harry Rakowski, Anna Woo, Mamta Khurana, Vijay S Chauhan
Journal: Circulation (2014)

Introduction: Localized regions of delayed conduction can promote re-entrant ventricular arrhythmias (VA). We hypothesized that narrow peaks in the QRS complex (QRSp), which may represent regions of conduction delay, would be associated with sustained VA in patients with hypertrophic cardiomyopathy (HCM). Methods: We prospectively enrolled 100 patients (51±15 yrs, 63 male) with HCM who had received primary (n=96) or secondary prevention ICDs (n=4). Major HCM clinical risk factors (RF) were assessed pre ICD implantation. High resolution (1kHz sampling) digital 12 lead ECGs were recorded continuously for 3 minutes during intrinsic rhythm. Using custom software, QRSp for each precordial lead (Vnp) was defined by automatically detecting the number of positive peaks of ≤25ms duration within the QRS complex. VA was defined as cardiac arrest or appropriate ICD therapy in followup. Results: Over a median followup of 41 (20-97) months after ICD implantation, VA were observed in 21% of patients. Comparing +VA vs -V...
Syphilitic Aortitis in Retrospect
Authors: William S. Middleton
Journal: Annals of Internal Medicine (1931)

Article1 September 1931Syphilitic Aortitis in RetrospectWILLIAM S. MIDDLETON, M.D., F.A.C.P.WILLIAM S. MIDDLETON, M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-5-3-294 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe bedside-necropsy correlation of disease was in a considerable measure responsible for the dawn of modern clinical medicine in the late eighteenth and the early nineteenth centuries. In a majority of instances such studies can admittedly reveal only the irretrievable end products of disease; yet from such determinations it has not infrequently been possible to explain the clinical manifestations of a given entity and to discern its consecutive steps to the fatal termination. In more recent years other allied sciences have lent their impetus to the advance of clinical medicine; but the clinico-pathologic orientation still constitutes one of the most...References1 SCOTT RW: Syphilitic aortic insufficiency, Arch. Int. Med., 1924, xxxiv, 645. CrossrefGoogle Scholar2 SCOTT RW: Latent syphilis as a cause of heart disease, Ann. Clin. Med., 1927, v, 1028. Google Scholar3 SAPHIRSCOTT ORW: The involvement of the aortic valve in syphilitic aortitis, Am. Jr. Path., 1927, iii, 527. Google Scholar4 SAPHIRSCOTT ORW: Observations on 107 cases of syphilitic aortitis, with special reference to the aortic valve area, the myocardium and branches of the aorta, Am. Heart Jr., 1930, vi, 56. CrossrefGoogle Scholar5 SCOTT RW: Symptoms and clinical course of syphilitic aortic insufficiency, Am. Heart Jr., 1930, vi, 86. CrossrefGoogle Scholar6 MARTLAND HS: Syphilis of the aorta and heart, Am. Heart Jr., 1930, vi, 1. CrossrefGoogle Scholar7 WILLIUS FA: A study of the course of syphilitic cardiovascular disease, Am. Heart Jr., 1930, vi, 113. CrossrefGoogle Scholar8 TRIPIER R: Etudes Anatomo-Cliniques, Coeur-Vaisseaux-Poumons, 1909, Paris. Google Scholar9 WARTHIN AS: The new pathology of syphilis. The Harvey Lecture, 1917. Google Scholar10 HOOVER CF: Aortitis syphilitica, Jr. Am. Med. Assoc., 1920, lxxiv, 226. CrossrefGoogle Scholar11 KURTZEYSTER CMJA: Fluoroscopic studies of the heart and aorta in acquired and congenital syphilis, Am. Heart Jr., 1930, vi, 67. CrossrefGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Madison, Wisconsin*From the Department of Medicine, University of Wisconsin.†Received for publication February 26, 1931. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 September 1931Volume 5, Issue 3Page: 294-306 Issue Published: 1 September 1931 PDF downloadLoading ...
A memorable patient: "Just my nerves"
Authors: J. D Hubbard
Journal: BMJ (2001)

Several years ago, before I permanently abandoned the clinic for the laboratory, I attended an elderly lady in the emergency department. She presented with “chest pain,” always a guarantee of early attention, but this chest pain was due to a band of haemorrhagic skin vesicles over the distribution of the fifth right intercostal nerve. They were exquisitely …
Abstract 4346: One-year Outcomes After Implantation of Everolimus-eluting for Diabetic Patients With de-Novo Coronary Artery Stenoses: Insights From RESEARCH, T-SEARCH and X-SEARCH Registries
Authors: Yoshinobu Onuma, Nicolo Piazza, Chrysafios Girasis, Giovanna Sarno, Hector Garcia-Garcia, Jin-Ming Cheng, Ron van Domburg, Patrick Serruys
Journal: Circulation (2009)

Objective: Everolimus-eluting stents (EES) have been shown to be more effective than Paclicaxel-eluting stent (PES) in the context of randomized trials with selected patients. However, the comparat...
Folic Acid Reminder
Authors: Mike Mitka
Journal: JAMA (2001)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Body Mechanics and Health.
Authors: Joel Ernest Goldthwait
Journal: JAMA (1923)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal