THE ACTION OF PARAHYDROXYPHENYLISOPROPYLAMINE (PAREDRINE) ON THE HEART; A CLINICAL STUDY OF A NEW EPINEPHRINE-LIKE COMPOUND
Authors: Morris H. Nathanson
Journal: Annals of Internal Medicine (1939)

Article1 May 1939THE ACTION OF PARAHYDROXYPHENYLISOPROPYLAMINE (PAREDRINE) ON THE HEART; A CLINICAL STUDY OF A NEW EPINEPHRINE-LIKE COMPOUNDMORRIS H. NATHANSON, M.D., F.A.C.P.MORRIS H. NATHANSON, M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-12-11-1855 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptIt is well established that epinephrine is the most valuable therapeutic agent in the prevention and treatment of cardiac standstill. More recently the more stable compound, ephedrine, has been used in the treatment of the Adams-Stokes syndrome. The action of this drug in increasing ventricular excitability is variable and at times minimal, so that consistent results are not obtained and many therapeutic failures have been reported. In previous studies on the effect of drugs on the cardiac standstill induced by pressure on the carotid sinus,1it was found that the standstill could be prevented by a large group of substances...Bibliography1. NATHANSON MH: Effect of drugs on cardiac standstill induced by pressure on the carotid sinus, Arch. Int. Med., 1933, li, 387. Further observations on the effect of drugs on induced cardiac standstill, Ibid., 1934, liv, 111. CrossrefGoogle Scholar2. ALLESPRINZMETAL GAM: The comparative physiological actions of the dl-B-phenylisopropylamines, Jr. Pharm. and Exper. Therap., 1933, xlviii, 161. Google Scholar3. ABBOTTHENRY WOCM: Paredrine, a clinical investigation of a sympathomimetic drug, Am. Jr. Med. Sci., 1937, clxliii, 661. CrossrefGoogle Scholar4. CULLISTRIBE WEEM: Distribution of nerves in the heart, Jr. Physiol., 1913, xlvi, 141. CrossrefGoogle Scholar5. ROUTIER D: Action de l'adrenaline sur le coeur bloqué due chien, Compt.-rend. Soc. de biol., 1915, lxxviii, 375. Google Scholar6. DANIELOPOLUDANULESCU DV: Action de l'adrenaline dans la dissociation auriculo-ventriculaire incomplete, Compt.-rend. Soc. de biol., 1916, lxxix, 105. Google Scholar7. HARDOYHOUSSAY PJBA: Note sur l'action de l'adrenaline dans la dissociation auriculo-ventriculaire, Jr. de physiol. et de path. gén., 1917, xvii, 605. Google Scholar8. PHEARPARKINSON AGJ: Adrenalin in the Adams-Stokes syndrome, Lancet, 1922, ccii, 933. CrossrefGoogle Scholar9. PARKINSONBAIN JCW: The adrenalin treatment of Adams-Stokes disease, Lancet, 1924, ccvii, 311. CrossrefGoogle Scholar10. FEIL H: The use of epinephrin in the Stokes-Adams syndrome, Jr. Am. Med. Assoc., 1923, lxxx, 26. CrossrefGoogle Scholar11. BARTOSBURSTEIN EJ: Can variations in ventricular systole be determined from electrocardiogram deflections? Jr. Lab. and Clin. Med., 1924, ix, 217. Google Scholar12. KATZHAMBURGERLEV LNWWM: The diagnostic value of epinephrine in angina pectoris, Am. Heart Jr., 1932, vii, 371. CrossrefGoogle Scholar13. NATHANSON MH: The pathology and pharmacology of cardiac syncope and sudden death, Arch. Int. Med., 1936, lvii, 658. Google Scholar14. MILLESSMITH GPW: Effects of epinephrine on the heart, Am. Heart Jr., 1937, xiv, 198. CrossrefGoogle Scholar15. DOUGLASGELFANDSHOOKHOFF AHBC: Production by epinephrine of S-T changes in the electrocardiogram of the cat, similar to those of coronary occlusion, Am. Heart Jr., 1937, xiv, 211. CrossrefGoogle Scholar16. WEISSBAKER SJP: The carotid sinus in health and disease, Medicine, 1933, xii, 297. CrossrefGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Los Angeles, California*Received for publication December 21, 1937.From the Department of Medicine, University of Southern California and the Medical Service, Los Angeles County General Hospital. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byStokes-Adams DiseaseOn the Treatment of Heart Block with Adrenergic Substances1The interaction of sympathomimetic pressor amines: Inversion of the vonedrine pressor action by paredrineUntersuchungen über den Einfluß des vegetativen Nervensystems auf das ElektrokardiogrammStudies of the variation in circulatory and respiratory responses to carotid sinus stimulation in manThe cardiovascular effects of paredrineA study of the analeptic value of certain drugs in the treatment of quinidine depression 1 May 1939Volume 12, Issue 11Page: 1855-1869KeywordsDrugsEpinephrineHeartHospital medicineLongitudinal studiesMedical services ePublished: 1 December 2008 Issue Published: 1 May 1939 PDF downloadLoading ...