tbuckley/cabot-search huggingface dataset:
Abstract 483: Serine phosphorylation of vasodilator-stimulated phosphoprotein defines the malignant cell phenotype in colon cancer
Authors: Mehboob Ali, Giovanni M. Pitari
Journal: Cancer Research (2012)

Abstract Metastasis is the principal pathological process underlying mortality for colorectal cancer, the third deadly cancer worldwide. During tumor invasion, cancer cells assume a mesenchymal morphology that confers migratory and proliferative advantages. One of the mechanisms regulating malignant cell shape is the activity of the vasodilator-stimulated phosphoprotein (VASP) on the actin cytoskeleton. Here, human colon carcinoma cells were treated with cell permeant analogs of cAMP or cGMP, to preferentially induce VASP Ser157 (pVASP-Ser157) or Ser239 (pVASP-Ser239) phosphorylation, and examined by confocal microscopy, western blotting and colony formation. Confirming previous results, cancer dynamic membrane regions formed by the actin cytoskeleton were differentially modulated by VASP Ser phosphorylation. However, treatments with cAMP, which promoted a mesenchymal cell phenotype, reduced E-cadherin at tumor cell-cell junctions and enhanced vimentin and vinculin levels. In contrast cGMP induced an opposite cell morphology with increased E-cadherin-rich cell-cell contacts and decreased cellular vimentin and vinculin. Moreover, the cAMP-dependent phenotype increased the cancer cell ability to form tumor colonies, while cGMP compromised that metastatic potential. Importantly, cyclic nucleotide effects were mediated by selective VASP Ser phosphorylation, because VASP phosphomutants at Ser157 and Ser239 blocked cAMP or cGMP actions, respectively. Together, these findings suggest that in colon cancer cells pVASP-Ser157 and pVASP-Ser239 are critical determinants of the malignant phenotype, which define the function of actin cytoskeletal regulators, invasive cell morphology and tumorigenic potential. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 103rd Annual Meeting of the American Association for Cancer Research; 2012 Mar 31-Apr 4; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2012;72(8 Suppl):Abstract nr 483. doi:1538-7445.AM2012-483
Plasma levels of adrenomedullin, a newly identified hypotensive peptide, in patients with hypertension and renal failure.
Authors: T Ishimitsu, T Nishikimi, Y Saito, K Kitamura, T Eto, K Kangawa, H Matsuo, T Omae, H Matsuoka
Journal: Journal of Clinical Investigation (1994)

Adrenomedullin is a potent hypotensive peptide newly discovered in pheochromocytoma tissue by monitoring its elevating activity on platelet cAMP. We measured plasma concentration of adrenomedullin in patients with essential hypertension and chronic renal failure. As compared with normal subjects, plasma adrenomedullin was increased by 26% (P < 0.05) in hypertensives without organ damage and by 45% (P < 0.005) in those with organ damage. The increase in plasma adrenomedullin was more prominent in renal failure than in hypertension. Renal failure patients with plasma creatinine of 1.5-3, 3-6, and > 6 mg/dl had higher plasma adrenomedullin levels than healthy subjects by 78% (P < 0.05), 131% (P < 0.001), and 214% (P < 0.001), respectively. Moreover, adrenomedullin showed intimate correlations with norepinephrine, atrial natriuretic peptide, and cAMP in plasma (r = 0.625, P < 0.001; r = 0.656, P < 0.001; and r = 0.462, P < 0.001; respectively). Thus, plasma adrenomedullin is supposed to increase in association with changes in sympathetic nervous activity and body fluid volume in hypertension and renal failure. Considering its potent vasodilator effect, adrenomedullin may be involved in the defense mechanism preserving the integrity of the cardiovascular system in these disorders.
An Evaluation of the ‘Coping with Depression Course’ for Relapse Prevention with Unipolar Depressed Patients
Authors: Christine Kuehner
Journal: Psychotherapy and Psychosomatics (2005)

&lt;i&gt;Background:&lt;/i&gt; Patients with treated episodes of depression are at high risk of relapse and recurrence. This study describes the clinical course of patients who had received cognitive-behavioral group intervention for relapse prevention. &lt;i&gt;Method:&lt;/i&gt; Forty-four remitted unipolar depressed patients with recently treated episodes of illness participated in a 16-week group program, the ‘Coping with Depression Course’ (CWD). The majority of patients had suffered from multiple episodes of depression and nearly half of them were only partially remitted when they started the program. Assessments took place throughout the intervention and 17–23 months after the pretest. Descriptive analyses included proportions of reliable and clinically significant improvements, and cumulative relapse rates were estimated using survival analysis. &lt;i&gt;Results:&lt;/i&gt; At posttest, residual depression and dysfunctional attitudes had significantly decreased. Improvements were similar in patients with and those without parallel antidepressant medication. Two thirds of patients starting within a dysfunctional depression range showed a clinically significant improvement at the end of the intervention. The estimated cumulative relapse rates at 6, 12, 17, and 23 months after pretest were 13.6, 30.0, 37.0 and 44.9%. &lt;i&gt;Conclusions:&lt;/i&gt; Participants appeared to be protected from relapse during active intervention, but a substantial proportion suffered relapses in the postintervention period. Further research into the CWD is needed within the framework of randomized controlled trials.
The Practical Importance of Well Established Facts in Therapeutics.
Authors: J. H. Stallard
Journal: JAMA (1895)

<h3>To the Editor:</h3> —In order to explain the undeniably miraculous effects of the large dose of alcohol by which on the Alps I was restored from a condition of profound general prostration to one of ability and health, Dr. Davis is obliged to ignore his so-called established facts as regards depression of the nervous system, the diminution of muscular force and the alteration of blood consequent on defective oxygenation and retarded metabolism, and to be driven back on its supposed anesthetic action on the partially sensitive vagus and the insensitive vasomotor nerves. He thinks a dose of chloroform or ether would have produced the same effect. I do not think so. With chloroform I should have been put to sleep never to awaken again. If my vagus and vasomotor system required a sedative it must have been supplied by healthy blood, for as soon as the circulation was restored and
Cellular mechanisms mediating rat renal microvascular constriction by angiotensin II.
Authors: T Takenaka, H Suzuki, K Fujiwara, Y Kanno, Y Ohno, K Hayashi, T Nagahama, T Saruta
Journal: Journal of Clinical Investigation (1997)

To assess cellular mechanisms mediating afferent (AA) and efferent arteriolar (EA) constriction by angiotensin II (AngII), experiments were performed using isolated perfused hydronephrotic kidneys. In the first series of studies, AngII (0.3 nM) constricted AAs and EAs by 29+/-3 (n = 8, P < 0.01) and 27+/-3% (n = 8, P < 0.01), respectively. Subsequent addition of nifedipine restored AA but not EA diameter. Manganese (8 mM) reversed EA constriction by 65+/-9% (P < 0.01). In the second group, the addition of N-ethylmaleimide (10 microM), a Gi/Go protein antagonist, abolished AngII- induced EA (n = 6) but not AA constriction (n = 6). In the third series of experiments, treatment with 2-nitro-4-carboxyphenyl-N, N-diphenyl-carbamate (200 microM), a phospholipase C inhibitor, blocked both AA and EA constriction by AngII (n = 6 for each). In the fourth group, thapsigargin (1 microM) prevented AngII-induced AA constriction (n = 8) and attenuated EA constriction (8+/-2% decrease in EA diameter at 0.3 nM AngII, n = 8, P < 0.05). Subsequent addition of manganese (8 mM) reversed EA constriction. Our data provide evidence that in AAs, AngII stimulates phospholipase C with subsequent calcium mobilization that is required to activate voltage-dependent calcium channels. Our results suggest that AngII constricts EAs by activating phospholipase C via the Gi protein family, thereby eliciting both calcium mobilization and calcium entry.
Iron-deficiency Anaemia
Authors: M. E. Lampard
Journal: BMJ (1956)

We report the results of a five year survey of FRAXA and FRAXE mutations among boys aged 5 to 18 with special educational needs (SEN) related to learning disability. We tested their mothers using the X chromosome not transmitted to the son as a control chromosome, and the X chromosome inherited by the son to provide information on stability of transmission. We tested 3738 boys and 2968 mothers and found 20 FRAXA and one FRAXE full mutations among the boys and none among the mothers. This gives an estimated prevalence of full mutations in males of 1 in 5530 for FRAXA and 1 in 23 423 for FRAXE. We found an excess of intermediate and premutation alleles for both FRAXA and FRAXE. For FRAXA this was significant at the 0.001 level but the excess for FRAXE was significant only at the 0.03 level. We conclude that the excess of intermediate and premutation sized alleles for FRAXA may well be a contributing factor to the boys9 mental impairment, while that for FRAXE may be a chance finding. We studied approximately 3000 transmissions from mother to son and found five instabilities of FRAXA in the common or intermediate range and three instabilities of FRAXE in the intermediate range. Thus instabilities in trinucleotide repeat size for FRAXA and FRAXE are rare, especially among alleles in the common size range.
Immune Responses in Myeloma
Authors: A. L. Linton, M. G. Dunnigan, J. A. Thomson
Journal: BMJ (1963)

changes, which resembled patchy pneumonic consolidation.The jugular venous pressure was not raised.Spontaneous recovery once occurred from pulmonary oedema which developed after the excision of a glioma.Although common at necropsy and often severe, pulmonary oedema in subjects dying with intracranial lesions did not kill those who might otherwise have survived.The intracranial condition appeared irrecoverable in each case.I am grateful to Mr. Wylie McKissock for the opportunity to make this study; to Professor A.
Direct maxacalcitol injection into hyperplastic parathyroids improves skeletal changes in secondary hyperparathyroidism
Authors: K. Shiizaki, I. Hatamura, S. Negi, T. Sakaguchi, F. Saji, K. Kunimoto, M. Okamoto, I. Imazeki, Y. Muragaki, T. Akizawa
Journal: Kidney International (2006)
Intraperitoneal calcium for resistant symptomatic hypocalcaemia after parathyroidectomy in chronic renal failure
Authors: T J Thompson, T J Neale
Journal: BMJ (1988)

Un malade de 25 ans, atteint de nephrite, traite par hemodialyse depuis 1978 puis par dialyse peritoneale depuis 1982 subit une parathyroidectomie subtotale qui ameliore rapidement l'etat des os et calme le prurit mais provoque une hypocalcemie necessitant un traitement par perfusions puis par injections intraperitoneales de chlorure de calcium
WATER: ENOUGH, MORE, OR LESS
Authors: Harris A. Houghton
Journal: JAMA (1926)

<h3>To the Editor:</h3> —I desire to make some supplementary remarks on an editorial which appeared inThe Journal, June 19, entitled, "Water: Enough, More, or Less." The editorial is correct so far as it goes. Some experiences that I have had with a low-water diet lead me to believe that it is not always harmless, and that simply to institute such a regimen without thought of the etiology of the edema would in many instances prejudice the recovery of the patient. It is admitted that inability to concentrate urine is a compensatory activity in true suburemia, i. e., when the urea concentration of the plasma is high, and that the continued welfare of the patient calls for the use of comparatively large quantities of water for the diuretic effect. This situation often occurs in moderate edemas. A low water diet under such circumstances is contraindicated, even for the purpose of
Newly Described Features Resulting From High-Magnification Dermoscopy of Tinea Capitis
Authors: Francesco Lacarrubba, Anna Elisa Verzì, Giuseppe Micali
Journal: JAMA Dermatology (2014)

Recent studies have reported "comma hairs" as a typical dermoscopic feature of tinea capitis observed at low magnification (×10). The aim of this study was to evaluate the dermoscopic aspects of tinea capitis at high magnification (×150) and its diagnostic role.Five children (2 boys and 3 girls; aged 4-10 years) with multiple scaly patches of alopecia underwent scalp dermoscopy, direct microscopic examinations, and mycological cultures of skin scrapings. Using low magnification (×30), typical comma hairs, "Morse code-like" hairs, and "zigzag" hairs were observed. When using high magnification (×150), additional features were horizontal white bands that appear as empty bands that are likely related to localized areas of fungal infection. These horizontal white bands are usually multiple and may cause the hair to bend and break. We also identified a new dermoscopic feature consisting of translucent, easily deformable hairs that look weakened and transparent and show unusual bends; they are likely the result of a massive fungal invasion involving the whole hair shaft. Direct microscopic examination showed fungal infection and results of mycological culture were positive for Microsporum canis in all cases.The identification of new findings using higher-magnification dermoscopy may enhance the diagnosis of tinea capitis and be of help to better understand some pathogenetic mechanisms.
Multiple-puncture Vaccination with Freeze-dried B.C.G. Vaccine in Schoolchildren
Authors: M. I. Griffiths, T. W. Brindle, E. H. Gordon, T. Holme, B. Jones
Journal: BMJ (1961)

MENTAL HOSPITAL INS AND OUTSDementia has now replaced schizophrenia as the commonest cause of a stay in hospital of more than two years.The decrease in the number of schizophrenic illnesses becoming chronic may well lead to a fall in the total patient population of 30% over the next 20 years.If, in addition, changes in national policy are effective, mental hospitals may perhaps be reduced to one-quarter of their present size.I am indebted to the medical superintendents and other staff of 38 hospitals for help in tracing the progress of 124 transferred patients; and to Dr. J. A. Scott, Medical Officer of Health for London, and to the Town Clerk of Lewisham for help in calculating the population at risk.
Curing HIV-associated pulmonary arterial hypertension: Figure 1–
Authors: C. Tcherakian, E. Rivaud, D. Zucman, A-C. Metivier, L-J. Couderc
Journal: European Respiratory Journal (2012)

To the Editors:

Pulmonary arterial hypertension (PAH) results from chronic obstruction of small pulmonary arteries, leading to right ventricular failure and ultimately death. PAH is a severe complication, known to be related to HIV infection [1]. The frequency of PAH in HIV patients is strikingly higher than in the general population and the fourth-leading cause of PAH in the French registry [2]. The incidence of PAH related to HIV (PAH-HIV) has not decreased over time, despite efficient anti-retroviral therapy (ART) [3].

Since its description in 1987, PAH-HIV has been well characterised and multiple therapeutic strategies have been proposed, but no full recovery has yet been published. Here, …
The Neurogenic Vasoconstrictor Effect of Digitalis on Coronary Vascular Resistance
Authors: Nason P. Hamlin, James T. Willerson, Hasan Garan, William John Powell
Journal: Journal of Clinical Investigation (1974)

The coronary vasoconstrictor properties of digitals were evaluated in 61 anesthetized, openchest dogs after coronary sinus cannulation and under conditions of a constant heart rate (atrioventricular pacing) and near-constant blood pressure. The contribution of alpha adrenergic receptor stimulation to the digitalis-induced increase in coronary vascular resistance (CVR) was examined. With Na pentobarbital anesthesia (16 dogs), intravenous acetylstrophanthidin (0.5 mg) caused a significant (P<0.05) rise in CVR from 1 through 9 min after injection. The peak increase was +11±2% SE of the control of 1.8±0.2 mm Hg/cm3/min. The mean time to peak effect was 3 min, and to recovery was 21 min. Prior alpha adrenergic receptor blockade with phenoxybenzamine in 11 animals reduced (P<0.05) the acetylstrophanthidin-induced peak of CVR and substantially decreased (P<0.05) the time to recovery (5 min). Intravenous digoxin (1.0 mg) with Na pentobarbital anesthesia (five dogs) had no significant effect on CVR. However, with chloralose and urethane anesthesia (nine dogs) the same dose of digoxin produced a significant rise in CVR from 3 through 30 min. The peak increase was +20±3% of control (1.4±0.1 mm Hg/cm3/min). One-third the dose of intravenous digoxin (0.35 mg) produced a 9.5±1.0% increase in CVR (five additional dogs). Myocardial oxygen consumption did not change significantly in nine dogs after intravenous digoxin. In 10 additional dogs pretreated with phenoxy-benzamine and in 7 dogs pretreated with mecamylamine, the increase in CVR did not occur after 1.0 mg of intravenous digoxin. Thus there is a coronary vasoconstrictor effect of intravenous acetylstrophanthidin and digoxin, of rapid onset, which is mediated through alpha adrenergic receptor stimulation.
CHARACTERISTICS OF NEOINTIMAL HYPERPLASIA COMPARED WITH DES AND BMS IN EARLY- AND LATE-PHASE ANALYSIS OF OPTICAL COHERENCE TOMOGRAPHY
Authors: Kenji Goto, Hideo Takebayashi, Hideki Nishiyama, Yasukazu Fujiwara, Yuetsu Kikuta, Katsumasa Sato, Sunao Kodama, Masahito Taniguchi, Shigeki Hiramatsu, Seiichi Haruta
Journal: Journal of the American College of Cardiology (2011)
Occupational Lung Disease
Authors: W. K. C. MORGAN
Journal: Annals of Internal Medicine (1983)

Letters and Corrections1 July 1983Occupational Lung DiseaseW. K. C. MORGAN, M.D.W. K. C. MORGAN, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-99-1-124 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: I feel a reply to Dr. Keogh's letter in the April issue (1) is necessary. He complains that the present system of awarding compensation to the disabled worker is unfair; I agree. I still believe in liberty and justice for all, and nothing is more distressing than to see how claimants with possible asbestosis are treated. The moment workmen's compensation is mentioned, Blue Cross and Blue Shield immediately withdraw their cover. This action invariably means the workers have to pay for investigations themselves and even when their claim is sustained they often wait 2 or more years...References1. KEOGH J. Occupational lung disease and compensation [Letter]. Ann Intern Med. 1983;98:553. LinkGoogle Scholar2. WAGNERSLEGGSMARCHAND JCP. Diffuse mesothelioma and asbestos exposure in the North Western Cape Province. Br J Ind Med. 1960;17:260-71. MedlineGoogle Scholar3. DOLL R. The mortality from lung cancer in asbestos workers. Br J Ind Med. 1955;12:81-6. MedlineGoogle Scholar4. BERENSON A. Compensation for occupational lung disease [Letter]. Ann Intern Med. 1983;98:409. LinkGoogle Scholar1. BROWN T. Occupational lung disease and compensation [Letter]. Ann Intern Med. 1983;98:553. LinkGoogle Scholar2. SHOR G. Occupational lung disease and compensation [Letter]. Ann Intern Med. 1983;98:553-4. LinkGoogle Scholar3. RICHMAN S. Why change? A look at the current system of disability determination and workers' compensation for occupational lung disease. Ann Intern Med. 1982;97:908-14. LinkGoogle Scholar4. . An Interim Report to the Congress on Occupational Disease. Washington, D.C.: U. S. Government Printing Office; 1980. Google Scholar5. MAISONPIERRE A. Can the compensation system cope with occupational disease? In: THEBERGE LJ, HOLLENSHEAD NH, MUTH RJ, WYERMAN JK, WUERTHNER JJ JR, eds. Proceedings of the Conference on Workers' Compensation and Workplace Liability. Washington, D.C.: National Legal Center for the Public Interest; 1981:326-39. Google Scholar6. BARTHHUNT PW. Workers Compensation and Work-Related Illness and Disease. Cambridge, Massachusetts: The MIT Press; 1980:268. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: University Hospital 339 Windermere Road; London, Ontario Canada N6A 5A5 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 July 1983Volume 99, Issue 1Page: 124-125KeywordsLungs Issue Published: 1 July 1983 PDF DownloadLoading ...
An in vivo study of the total occlusion method for the analysis of forward and backward pressure waves
Authors: D. L. NEWMAN, S. E. GREENWALD, N. L. R. BOWDEN
Journal: Cardiovascular Research (1979)

The arterial pressure wave, Pm, is composed of a forward travelling wave, Pf, and a backward travelling wave, Pb, resulting from partial reflection of PI at the peripheral beds. The magnitude of Pb depends on the degree of vasoconstriction. Total occlusion of the vessel distal to the pressure measurement site results in a wave which is equal to 2Pf. Subtraction of the derived Pf wave from Pm gives Pb, provided there is no re-reflection of Pb by proximal discontinuities. To test the validity of this total occlusion method for the determination of the components of Pm, measurements were carried out in an anaesthetised dog and the results compared with the method of Westerhof et al., (1972). The measurements were made at three arterial sites: 1. in the aorta just proximal to the junction of the renal artery; 2. at the termination of the aorta; and 3. in the femoral artery. The magnitude of Pb was varied by the infusion of vasoactive drugs. There was good agreement between the two methods at site 1 but at the other two sites the agreement was less good. It is shown that this is the result of re-reflection of the backward travelling waves produced by the occlusion at the aortic termination and the renal artery junction.
Hospital clinical records.
Authors: A Nicol, J Sheppard
Journal: BMJ (1985)

from the pharmacy budget, using donor recruitment staff, or running a simple cash box system and asking recipients to contribute.In France central donor banks have been established, and samples are distributed to AID centres.sThe French system has the advantage that uniform standards may be applied, hazards monitored, and the number of pregnancies from any one donor restricted.In France one donor could not give samples to two different hospitals-as could happen in some of the larger British cities.There is no evidence of damage to the deoxyribonucleic acid or of teratogenicity from the use of donor or frozen donor semen"the main risk to the recipient seems to be transmissible disease.At present donated samples cannot be guaranteed to be free from venereal disease, for with current resources it is not practicable to test each sample.This would be another advantage of a centralised recruitment centre.Couples may now be told, then, that the rates of concep- tion from AID approach those from natural conception.Now that prognostic factors have been identified some couples may be selected for "do it yourself," low cost AID schemes so that medical efforts may be concentrated on those who fail and those who have poor prognostic factors.The place of AID in the management of male infertility may, however, require reappraisal if the preliminary results of in vitro fertilisation for male infertility are confirmed from life table methods of analysis.