CORAMINE (NIKETHAMIDE) IN BARBITURATE POISONING: COMPARISON WITH PICROTOXIN; PRELIMINARY REPORT
Authors: J C WATTS, J RUTHBERG
Journal: Annals of Internal Medicine (1948)

Article1 December 1948CORAMINE (NIKETHAMIDE) IN BARBITURATE POISONING: COMPARISON WITH PICROTOXIN; PRELIMINARY REPORTJOSEPH C. WATTS, M.D., F.A.C.P., JACK RUTHBERG, M.D.JOSEPH C. WATTS, M.D., F.A.C.P., JACK RUTHBERG, M.D.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-29-6-1104 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptRecently a marked increase in the number of cases of poisoning due to barbituric acid derivatives has made an effective antidote or analeptic a matter of paramount importance. The drugs of the barbiturate group have been readily available to the laity, and newspaper publicity, instead of helping the situation, appears actually to have increased the number of cases of attempted suicide from these drugs.Various antidotes for human barbiturate poisoning have been in use for years. Picrotoxin and coramine (as coriamyrtin) were used as early as 1891-1892.1Arnett2administered picrotoxin in 1933 after Maloney, Fitch and Tatum3had demonstrated its...Bibliography1. KOPPEN M: Pikrotoxin and Coriamyrtin als Collapsmittel, Arch. Path. u. Pharmakol., 1891-1892, xxix, 327. Google Scholar2. ARNETT JH: Ephedrine and picrotoxin used successfully in amytal poisoning, Jr. Am. Med. Assoc., 1933, c, 1597. Google Scholar3. MALONEYFITCHTATUM AHRHAL: Picrotoxin as antidote in acute poisoning by the shorter acting barbiturates, Jr. Pharmacol. and Exper. Therap., 1931, xli, 465-482. Google Scholar4. KOPPANYILINEGARDILLE TCRJM: Studies on barbiturates; analysis of the barbiturate-picrotoxin antagonism, Jr. Pharmacol. and Exper. Therap., 1936, lviii, 199-228. Google Scholar5. BURDICKROVENSTINE DLEA: Picrotoxin in barbiturate poisoning, Ann. Int. Med., 1945, xxvii, 819-826. Google Scholar6. UHLMAN F: Über Coramin, Ztschr. f. d. ges. exper. Med., 1924, xliii, 556. CrossrefGoogle Scholar7. GUTH K: Über Coramin, München. med. Wchnschr., 1925, lxxii, 562. Google Scholar8. SCHUBELGEHLEN KW: Vergleicharde Untersuchargen ober atmungserregerde. Pharmaka am morphin vergiftelen Kaninchen, Arch. f. exper. Path., 1928, cxxxiii, 295. CrossrefGoogle Scholar9. KENNEDY WP: Effective counteraction of avertin narcosis, Lancet, 1932, i, 1143. CrossrefGoogle Scholar10. WOOD PM: Coramine in denarcotization and resuscitation. Preliminary report, Am. Jr. Surg., 1933, xxii, 86. CrossrefGoogle Scholar11. LEVIKRINSKY AACM: The effect of coramine in postpartum patients under the analgesic influence of barbituric acid drugs, New Eng. Jr. Med., 1936, ccxiv, 362. CrossrefGoogle Scholar12. SCHUBE PG: Study in use of coramine in dealing with the effects of barbituric acid derivative, New Eng. Jr. Med., 1936, ccxiv, 926-929. CrossrefGoogle Scholar13. FRATTEN PG: Analepti, coramine, Policlinico, 1940, xxvi, 1413-1415. Google Scholar14. HARRISGORDONGRAYBARTON HJOARLG: Apparent sensitivity to amigen, Jr. Am. Med. Assoc., 1946, cxxxii, 682-683. Google Scholar15. ANDROP S: Picrotoxin in barbiturate poisoning, Psychiat. Quart., 1944, xviii, 13. CrossrefGoogle Scholar16. FREIREICHLANDSBERG AWJW: Amphetamine (benzedrine) sulphate for acute barbiturate poisoning, Jr. Am. Med. Assoc., 1946, cxxxi, 661-663. CrossrefGoogle Scholar17. RICHARDS RW: Barbiturates and their action, Brit. Med. Jr., 1934, i, 331. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: JOSEPH C. WATTS, M.D., F.A.C.P.; JACK RUTHBERG, M.D.Affiliations: New York, N. Y.*Received for publication February 19, 1947.From the Department of Medicine, Queens General Hospital, New York City. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byPicrotoxinBarbiturate Poisoning 1 December 1948Volume 29, Issue 6Page: 1104-1114KeywordsAntidotesDrugsHospital medicineSuicide ePublished: 1 December 2008 Issue Published: 1 December 1948 PDF downloadLoading ...