ASSOCIATION OF MYASTHENIA GRAVIS AND HYPERTHYROIDISM, SHOWING RECIPROCAL RELATIONSHIP: REPORT OF A CASE AND REVIEW OF THE LITERATURE
Authors: Jacob John Robbins, Joseph S. Burkle
Journal: Annals of Internal Medicine (1960)

Case Reports1 April 1960ASSOCIATION OF MYASTHENIA GRAVIS AND HYPERTHYROIDISM, SHOWING RECIPROCAL RELATIONSHIP: REPORT OF A CASE AND REVIEW OF THE LITERATUREJACOB JOHN ROBBINS, JOSEPH S. BURKLEJACOB JOHN ROBBINSSearch for more papers by this author, JOSEPH S. BURKLESearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-52-4-890 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptMyasthenia, or muscle weakness, is not an uncommon symptom in toxic goiter, but the coexistence of myasthenia gravis and hyperthyroidism has rarely been reported. MacLean and Wilson,1adding one of their own, tabulate 11 cases previously reported. In view of the long duration of life in myasthenia gravis, and the frequency of hyperthyroidism, the concurrent appearance of the two conditions, on the basis of statistical probabilities alone, could be expected to be much higher than the literature suggests. However, Kane2states that, when patients with chronic thyrotoxic myopathy and exophthalmic ophthalmoplegia are eliminated, there are fewer than two dozen well...Bibliography1. MacLeanWilson BJA: See-saw relationship between hyperthyroidism and myasthenia gravis, Lancet 1: 950-953 (May 8) 1954. CrossrefGoogle Scholar2. Kane CA: Effect of certain endocrine glands on myasthenia gravis, Am. J. Med. 19: 729-733, 1955. CrossrefMedlineGoogle Scholar3. Thorner MW: Relation of myasthenia gravis to hyperthyroidism, Arch. Int. Med. 64: 330, 1939. CrossrefGoogle Scholar4. BauerBlahe FKWH: Treatment of hyperthyroidism with individually calculated doses of I131 , Arch. Int. Med. 99: 194-201, 1957. CrossrefGoogle Scholar5. ThornEder GWHA: Studies on chronic thyrotoxic myopathy, Am. J. Med. 1: 583, 1946. CrossrefMedlineGoogle Scholar6. BartelKingsley ECJW: Hyperthyroidism associated with myasthenia gravis, Lahey Clin. Bull. 6: 101-108 (Apr.) 1949. MedlineGoogle Scholar7. MillikanHaines CHSF: The thyroid gland in relation to neuromuscular disease, Arch. Int. Med. 92: 5-39, 1953. CrossrefGoogle Scholar8. Laurent PE: Acute thyrotoxic bulbar palsy, Lancet 1: 87, 1944. CrossrefGoogle Scholar9. Brain WR: Diseases of the nervous system, 1940, Oxford University Press, London. Google Scholar10. KowallisHainesPemberton GFSFJ: Goiter with associated myasthenia gravis, Arch. Int. Med. 69: 41-50, 1942. CrossrefGoogle Scholar11. LevyMeadowsGunnar GWRRM: The association of Graves' disease with myasthenia gravis, with a report of five cases, Ann. Int. Med. 35: 134-147, 1951. LinkGoogle Scholar12. PrasedLevi RJE: Thyrotoxic myopathy and myasthenia gravis, J. Clin. Endocrinol. and Metabolism 15: 476-480, 1955. CrossrefGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: *Received for publication September 14, 1959.From the Medical Department, U. S. Naval Hospital, St. Albans, N. Y.Opinions expressed are those of the writers, and are not to be construed as reflecting the views of the Naval Service.Requests for reprints should be addressed to Joseph S. Burkle, Captain (MC) USN, U. S. Naval Hospital, St. Albans, Long Island 25, N. Y. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byMyasthenia gravis: Overlap with ?polyendocrine? autoimmunityA Case Report of Myasthenia Gravis Coexistent with Thymic Tumor and HyperthyroidismDisorders of General FeelingsMyasthenia gravis in uncontrolled juvenile hyperthyroidismThyrotoxic crisis and transient myasthenia gravis in pregnancyAcute Tubular Necrosis Consequent to Encephalomyopathic Thyroid Crisis 1 April 1960Volume 52, Issue 4Page: 890-893KeywordsHyperthyroidismMusclesMyasthenia gravis ePublished: 1 December 2008 Issue Published: 1 April 1960 PDF downloadLoading ...