THE EFFECT OF CORTONE AND ACTH ON THE HISTOPATHOLOGIC LESIONS OF RHEUMATOID ARTHRITIS
Authors: B M NORCROSS, L M LOCKIE, A G CONSTANTINE, J H TALBOTT, R H STEIN
Journal: Annals of Internal Medicine (1952)

Article1 March 1952THE EFFECT OF CORTONE AND ACTH ON THE HISTOPATHOLOGIC LESIONS OF RHEUMATOID ARTHRITISBERNARD M. NORCROSS, M.D., F.A.C.P., L. MAXWELL LOCKIE, M.D., F.A.C.P., ANTHONY G. CONSTANTINE, M.D., JOHN H. TALBOTT, M.D., F.A.C.P., ROBERT H. STEIN, M.D.BERNARD M. NORCROSS, M.D., F.A.C.P.Search for more papers by this author, L. MAXWELL LOCKIE, M.D., F.A.C.P.Search for more papers by this author, ANTHONY G. CONSTANTINE, M.D.Search for more papers by this author, JOHN H. TALBOTT, M.D., F.A.C.P.Search for more papers by this author, ROBERT H. STEIN, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-36-3-751 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThis investigation was intended to demonstrate any effect of Cortone and ACTH upon the histopathologic lesions of rheumatoid arthritis. In 1945, Freund, Steiner and their associates1, 2described an inflammatory lesion of striated muscle in patients with rheumatoid arthritis. This lesion, consisting of a localized collection of lymphocytes, was widely distributed in the skeletal muscles, and was called "nodular polymyositis." The authors believed these lesions to be specific for rheumatoid arthritis, but other observers3-8have demonstrated the presence of similar changes in a variety of disease states and even in normal individuals. Two reports deserve special attention in this respect....Bibliography1. FreundSteinerLeichtentrittPrice HAGBAE: Nodular polymyositis in rheumatoid arthritis, Science 101: 202, 1945. CrossrefMedlineGoogle Scholar2. SteinerFreundLeichtentrittMaun GHABME: Lesions of skeletal muscles in rheumatoid arthritis; nodular polymyositis, Am. J. Path. 22: 103, 1946. Google Scholar3. Black-Schaffer B: Discussion of Steiner et al., Am. J. Path. 22: 647, 1946. Google Scholar4. ClawsonNobleLufkin BJJFNH: Nodular inflammatory and degenerative lesions of muscles from four hundred and fifty autopsies, Arch. Path. 43: 579, 1947. Google Scholar5. DeForestBuntingKenney GKHWE: Rheumatoid arthritis; diagnostic significance of focal cellular accumulations in skeletal muscles, Am. J. Med. 2: 40, 1947. CrossrefMedlineGoogle Scholar6. BunimSokoloffWilensMcEwen JJLSLC: Cellular aggregates in skeletal muscle of patients with rheumatic diseases other than rheumatoid arthritis, Abst., Ann. Rheum. Dis. 7: 251, 1948. MedlineGoogle Scholar7. SokoloffWilensBunimMcEwen LSLJJC: Diagnostic value of histologic lesions of striated muscle in rheumatoid arthritis, Am. J. M. Sc. 219: 174, 1950. CrossrefMedlineGoogle Scholar8. Ogryzlo MA: Chronic inflammatory lesions of skeletal muscle in rheumatoid arthritis and in other diseases, Arch. Path. 46: 301, 1948. Google Scholar9. RaganGrokoestBoots CAWRH: Effect of adrenocorticotrophic hormone (ACTH) on rheumatoid arthritis, Am. J. Med. 7: 741, 1949. CrossrefMedlineGoogle Scholar10. HenchKendallSlocumbPolley PSECCHHF: Effects of cortisone acetate and pituitary ACTH on rheumatoid arthritis, rheumatic fever, and certain other conditions, Arch. Int. Med. 85: 545, 1950. CrossrefGoogle Scholar11. BauerGiansiracusaRopes WJEMW: The natural course of rheumatoid arthritis and the changes induced by ACTH, Tr. A. Am. Physicians 63: 76, 1950. MedlineGoogle Scholar12. RaganHowesPlotzMeyerBlunt CELCMKJW: Effect of cortisone on production of granulation tissue in rabbit, Proc. Soc. Exper. Biol. and Med. 72: 718, 1949. CrossrefMedlineGoogle Scholar13. CreditorBevansMundyRagan MCMWLC: Effect of ACTH on wound healing in humans, Proc. Soc. Exper. Biol. and Med. 74: 245, 1950. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: *Received for publication June 1, 1951.From the University of Buffalo School of Medicine and the Buffalo General Hospital, Buffalo, New York.This study was aided by a grant from the Weed Foundation, Buffalo, New York.Portions of this paper were given at the annual meeting of the American Rheumatism Association, June 23, 1950, San Francisco, and also at the Western New York Regional Meeting of the American College of Physicians, October 14, 1950, Rochester, New York. Nextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byKurative ACTH-Wirkung bei chronischer Fremdserumkarditis des KaninchensDie Herz- und GefäßkrankheitenRHEUMATISM AND ARTHRITIS REVIEW OF AMERICAN AND ENGLISH LITERATURE OF RECENT YEARS (ELEVENTH RHEUMATISM REVIEW)* Part IIWILLIAM D. ROBINSON, M.D., F.A.C.P., JOSEPH J. BUNIM, M.D., F.A.C.P., WILLIAM S. CLARK, M.D., DARRELL C. CRAIN, M.D., F.A.C.P., EPHRAIM P. ENGLEMAN, M.D., F.A.C.P., DONALD C. GRAHAM, M.D., F.R.C.P. (C), MAX M. MONTGOMERY, M.D., F.A.C.P., BERNARD M. NORCROSS, M.D., F.A.C.P., CHARLES RAGAN, M.D., F.A.C.P., MARIAN W. ROPES, M.D., F.A.C.P., EDWARD F. ROSENBERG, M.D., F.A.C.P., CHARLEY J. SMYTH, M.D., F.A.C.P.Pulmonary lesions in “rheumatoid disease” with remarks on diffuse interstitial pulmonary fibrosisRheumatoid arthritis: A review of recent advances in our knowledge concerning pathology, diagnosis, and treatmentAetiology and pathogenesis of rheumatoid arthritisPhysiology of the Adrenal CortexINTERRUPTION BY TOPICAL CORTISONE OF LEUKOCYTIC CYCLES IN ACUTE INFLAMMATION IN MANFocal Infection in Relation to Health and Disease 1 March 1952Volume 36, Issue 3Page: 751-764KeywordsAdrenocorticotropic hormoneHospital medicineLesionsLymphocytesMusclesPolymyositisRheumatoid arthritisSkeletal muscles ePublished: 1 December 2008 Issue Published: 1 March 1952 Copyright & PermissionsCopyright, 1952, by The American College of PhysiciansPDF downloadLoading ...