tbuckley/cabot-search huggingface dataset:
Intermittent, Repetitive Corticosteroid-Induced Upregulation of Platelet Levels After Adenovirus-Mediated Transfer to the Liver of a Chimeric Glucocorticoid-Responsive Promoter Controlling the Thrombopoietin cDNA
Authors: Ko Narumi, Motoyoshi Suzuki, Wenru Song, Malcolm A.S. Moore, Ronald G. Crystal
Journal: Blood (1998)
Viagra Approval Information on the Internet
Authors: Stuart L. Nightingale
Journal: JAMA (1998)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
A Prospective, Randomized Evaluation of Prophylactic Intraaortic Balloon Counterpulsation in High Risk Patients With Acute Myocardial Infarction Treated With Primary Angioplasty fn1fn1Funding for this study was provided in part by unrestricted grants from Advanced Cardiovascular Systems, Inc., Santa Clara, California; Mallinkrodt Medical, Inc., Saint Louis, Missouri; Datascope Corporation, Montvale, New Jersey; St. Jude Medical, Chelmsford, Massachusetts; and Siemens Corporation, Iselin, New …
Authors: Gregg W. Stone, Dominic Marsalese, Bruce R. Brodie, John J. Griffin, Bryan Donohue, Costantino Costantini, Carlos Balestrini, Thomas Wharton, Paolo Esente, Michael Spain, Jeffrey Moses, Masakiyo Nobuyoshi, Mike Ayres, Denise Jones, Denise Mason, Lorelei Grines, William W. O’Neill, Cindy L. Grines
Journal: Journal of the American College of Cardiology (1997)
Adherence to interdisciplinary pulmonary rehabilitation program at a public hospital in Buenos Aires, Argentina
Authors: Clarisa Boim, Miguel Storni, Marta Cortiñaz, Maria Fernanda Monti, Marina Khoury, Sandra Chiervo
Journal: European Respiratory Journal (2014)

Introduction: Participation in a Pulmonary Rehabilitation Program (PRP) has been demonstrated to improve dyspnea, functional capacity and quality of life in patients with chronic respiratory disease. However compliance with PRP has been low.

Objective: To identify variables associated with compliance in an outpatient PRP at a Hospital in Argentina and also to evaluate the impact of the rehabilitation on program compliant patients. Method: A retrospective analysis was performed on 388 patients who were assessed for admission to PRP. The first stage of the program, which we have called “skills acquisition” consisted of both supervised physical training and educational lectures, twice weekly for 16 weeks. Patients were reassessed after this stage. In the present study PRP compliance refers to patient completion of the total sessions and reassessment.

Results: 26.29% of the 388 patients complied with PRP. Multiple logistic regression analysis (Forward Stepwise; p<0.10 to be eligible for entry into the model) was conducted to identify factors associated with “program compliance”. The final model was as follows: having health insurance coverage (OR=3.99; CI90%=2.24-7.12), commute time less than 60minutes (OR=2.07; CI90%=1.37-3.11) and availability of funds (OR=2.11; CI90%=1.03-4.31). All patients that performed the six minute walking test and Chronic Respiratory Questionnaire demonstrated significant improvement at the reassessment.

Conclusion: The results warn about low compliance and their relationship with the socioeconomic variables.
Hypoxemic Episodes and Adverse Neurodevelopmental Outcome in Extremely Preterm Infants
Authors: Lex W. Doyle
Journal: JAMA (2015)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Abstract 18108: Effects of a Heart Failure Family Caregiver Intervention on Caregiver Strain and Outcomes
Authors: Sandra B Dunbar, Rebecca A Gary, Elizabeth Corwin, Andrew Miller, Melinda K Higgins, Javed Butler
Journal: Circulation (2014)

Background and Purpose: Family Caregivers (FCGs) of persons with heart failure (HF) report social, emotional and physical concerns and life changes due to caregiving. Few interventions have addressed the needs of FCGs. This study designed and tested psychoeducational (PsychEd) and psychoeducational plus exercise (PsychEd+EX) interventions against a usual care attention control (UCAC) group for effects on perceived HF FCG caregiver strain (CS) and life changes specifically resulting from providing care. Methods: FCGs of persons with HF (N=127, mean age 55.3 ± 11.5 years, 92% women, 58% African American) were randomized to one of the three groups with data collected at baseline prior to randomization and at 6 months. Both PsychEd and PsychEd+Ex groups attended four weekly sessions focused on HF caregiving and FCG needs, coping, problem-solving, resources, and social support. PsychEd+Ex also received exercise counseling and support through scripted monthly phone calls. UCAC attended one group focused on heal...
Quality Improvement Organizations and Hospital Care—Reply
Authors: Claire Snyder, Gerard Anderson
Journal: JAMA (2005)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Targeting the hedgehog pathway: From bench to clinic
Authors: Frederic de Sauvage
Journal: Clinical Cancer Research (2008)

PL04-02   The Hedgehog (Hh) pathway is an ancient signaling cascade that directs patterning in most animals and is crucial for proper development. While Hh signaling is very active during most stages in embryogenesis, it remains relatively quiet in adult life. However, aberrant reactivation of the pathway in adult tissue can lead to the development of cancer. Hh pathway activation in tumors such as basal cell carcinoma (BCC) and medulloblastoma is the result of inactivating mutations in PATCHED (PTCH) or activating SMOOTHENED (SMO) mutations. Furthermore, in other solid tumors, such as colon and pancreas, Hh ligand expression is upregulated in tumor cells and acts in a paracrine manner to activate the pathway in the surrounding tumor stroma. A consequence of Hh pathway activation is the transcriptional upregulation of unique target genes and the expression levels of these transcripts that could serve as potential pharmacodynamic and predictive biomarkers of pathway activity. Targeting the Hh pathway with small molecule antagonists therefore provides new therapeutic opportunities for the treatment of both tumor types. GDC-0449, a systemic Hedgehog (Hh) pathway antagonist, was tested in a first-in-human, first-in class, Phase I study with locally advanced, multifocal or metastatic BCC patients. Antitumor activity was observed in BCC patients enrolled, thereby confirming the importance of inhibiting aberrant Hh signaling in tumors with mutations in the Hh pathway.
Abstract 980: Small molecule inhibitor of miR-155, SMM155I, inhibits epithelial-mesenchymal transition and tumor growth in cancer cells overexpressing miR-155
Authors: Cheng-Xiong Xu, William Kong, Donghwa Kim, Edward Richards, Fei Yan, Yueling Li, Domenico Coppola, Jin Q. Cheng
Journal: Cancer Research (2014)

Abstract Accumulating studies have shown that miR-155 is frequently up-regulated in a various types of human malignancy. Expression of miR-155 induces epithelial-mesenchymal transition (EMT), transformation, tumor growth and metastasis as well as chemoresistance, whereas inhibition of miR-155 reverses these processes. Here we report the discovery of a small molecule miR-155 inhibitor, SMM155I, by screening the National Cancer Institute Diversity Set. SMM155I directly binds to miR-155 and inhibits miR-155 interaction with its targeted mRNAs without effect on expression of miR-155 and other miRs. The inhibition of miR-155 by SMM155I resulted in suppression of cell migration, invasion and EMT in human cancer cells that harbor elevated miR-155. Furthermore, SMM155I potently inhibited tumor growth in nude mice of human cancer cells in which miR-155 is aberrantly expressed but not of those cancer cells in which it is not. These findings provide strong evidence for pharmacologically targeting miR-155 for anticancer drug discovery. Citation Format: Cheng-Xiong Xu, William Kong, Donghwa Kim, Edward Richards, Fei Yan, Yueling Li, Domenico Coppola, Jin Q. Cheng. Small molecule inhibitor of miR-155, SMM155I, inhibits epithelial-mesenchymal transition and tumor growth in cancer cells overexpressing miR-155. [abstract]. In: Proceedings of the 105th Annual Meeting of the American Association for Cancer Research; 2014 Apr 5-9; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2014;74(19 Suppl):Abstract nr 980. doi:10.1158/1538-7445.AM2014-980
有人说“静养”比运动好，对吗？
Authors: 杨秉辉
Journal: BMJ (2010)

确曾有人提倡此说，并以龟为例，说明不运动亦能长寿。不过我以为这个比方是不对的，人岂能与龟相提并论。即便是灵长类的动物，亚马孙河的一种懒猴，终日在树上静伏不动，其寿命亦只数年而已。医学上之所谓“静养”，实在是指病人对疾病应有的一种态度，即生了病让医生治疗．病人安心养病。应该不是对正常人谋求健康而言的，不应错位。
Value of acceleration flows and regurgitant jet direction by color Doppler flow mapping in the evaluation of mitral valve prolapse.
Authors: K Yoshida, J Yoshikawa, Y Yamaura, T Hozumi, M Shakudo, T Akasaka, H Kato
Journal: Circulation (1990)

To clarify the role of color Doppler echocardiography in the evaluation of mitral valve prolapse, we studied 49 consecutive patients in whom the sites of mitral valve prolapse were confirmed at the time of operation. The study group consisted of 22 patients with anterior leaflet prolapse, 24 patients with posterior leaflet prolapse, and three patients with multiple scallop prolapse (one patient with both anterior leaflet and middle scallop prolapse, and two patients with both medial and lateral scallop prolapse). Two-dimensional echocardiographic diagnosis of anterior leaflet prolapse was correct in all patients. The diagnosis of posterior leaflet prolapse by two-dimensional echocardiography, however, was mistaken as anterior leaflet prolapse in 16 (13 patients with medial scallop prolapse and three patients with lateral scallop prolapse) of the 24 patients according to current diagnostic criteria for mitral valve prolapse. Eight patients with middle scallop prolapse were diagnosed correctly by two-dimensional echocardiography. Acceleration flows in the left ventricle were observed by color Doppler echocardiography in all 49 patients. The sites of acceleration flows detected by color Doppler echocardiography coincided with those of prolapse confirmed in all at the time of operation. There was a significant correlation between the maximum area of acceleration flow signals and severity of mitral regurgitation estimated by angiography. In the 13 patients with medial scallop prolapse and the three patients with lateral scallop prolapse, a regurgitant jet originated from a bulged portion of the posterior leaflet and was directed toward the opposite left atrial cavity to the bulged portion by short-axis images of color Doppler echocardiography.(ABSTRACT TRUNCATED AT 250 WORDS)
Congenital Anomalies of the Viscera: Their Embryological Basis.
Authors: John Lewis Bremer
Journal: Annals of Internal Medicine (1957)

Reviews 169 obstruction is not 'muscular' or tubular, but in the author's opinion is fibrous and annular or diaphragmatic.In 30-40 % of cases of Fallot's tetralogy there is valvar, not infundibular, obstruction although the infundibulum is reduced.In about 20 % infundibular and valvar obstruction co-exist.The opposition to acceptance that pulmonary valvar stenosis occurs quite frequently in Fallot's tetralogy is removed by Sir Russell's figures.The monograph is handsomely produced and profusely and clearly illustrated.It will be essential for thoracic surgeons, for morbid anatomists and not a few anatomists.Unlike Sir Arthur Keith's severe strictures upon the standard treatises of 1904 dealing with the function and diseases of the heart this excellent work does lie within the field of practical medicine and will be immensely useful to physician and physiologist alike.
Risk of death does not alter the efficacy of hydrocortisone therapy in a mouse E. coli pneumonia model
Authors: Yan Li, Xizhong Cui, Xuemei Li, Steven B. Solomon, Robert L. Danner, Steven M. Banks, Yvonne Fitz, Djillali Annane, Charles Natanson, Peter Q. Eichacker
Journal: Intensive Care Medicine (2007)
Treatment strategies and visual acuity outcomes in chronic postoperative propionibacterium acnes endophthalmitis
Authors: W.Lloyd Clark, Peter K Kaiser, Harry W Flynn, Armando Belfort, Darlene Miller, David M Meisler
Journal: Ophthalmology (1999)

To report the treatment strategies and visual acuity outcomes of chronic postoperative endophthalmitis caused by Propionibacterium acnes.Retrospective noncomparative case series.All patients presenting 8 or more weeks after cataract surgery with intraocular inflammation caused by culture-proven P. acnes infection and treated at two institutions from 1974 through 1996 were included.Patients underwent three different initial treatment strategies. The study did not have a defined treatment protocol, but all patients received intraocular antibiotics. Patients were not randomly assigned to the various treatment strategies.Final visual acuity and effectiveness of various treatment procedures either as initial or follow-up therapy were assessed.Using the 3 initial strategies, 36 patients were treated: (1) intraocular antibiotic injection alone (IOAB; n = 12); (2) pars plana vitrectomy and IOAB injection (PPV; n = 10); and (3) PPV with subtotal capsulectomy and IOAB injection (PPV-PC; n = 14). The number of patients with recurrent or persistent inflammation after one of the three initial treatment strategies were as follows: (1) IOAB alone, 12 (100%); (2) PPV, 5 (50%); and (3) PPV-PC, 2 (14%). None of the patients that underwent subsequent PPV, total capsular bag removal, IOAB injection, and either intraocular lens (IOL) exchange or removal had persistent or recurrent intraocular inflammation. Overall, final visual acuity was 20/40 or better in 18 patients (50%), and a total of 28 patients (78%) retained 20/400 or better vision. The mean follow-up after the last treatment was 2.9 years.In this series of chronic P. acnes endophthalmitis, initial treatment with IOAB injection alone or vitrectomy without capsulectomy was associated with high rates of recurrent or persistent intraocular inflammation. Pars plana vitrectomy, partial capsulectomy, and IOAB injection without IOL exchange was usually successful on long-term follow-up. In patients with recurrent intraocular inflammation, pars plana vitrectomy, total capsular bag removal, IOAB injection, and IOL exchange or removal was a uniformly successful strategy. In contrast to other types of postoperative endophthalmitis, IOL exchange can be considered in these patients after total capsular bag removal.
Four Figures on a Step
Authors: M. Therese Southgate
Journal: JAMA (2002)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
A memorable patient: In favour of the weed
Authors: C. Tyler
Journal: BMJ (2000)

Since the 1970s, Danish women in some age groups have experienced increasing numbers of deaths.This can be explained by the longstanding heavy use of tobacco.The risk of dying of causes attributed to tobacco is still highest among men, but it is the trend among women that is of most concern.Denmark is one of the few countries in which the estimated annual mortality from smoking is almost identical for men and women.No country has yet experienced the full impact of smoking on women's health, 5 but there is now strong evidence that when women have smoked cigarettes regularly for several decades the percentage of deaths attributable to tobacco approaches that of men. 4 This situation has almost been reached in Denmark, and the trend may be a forerunner of a development that has begun or will begin in other European countries.Danish life expectancy cannot be improved greatly without a substantial reduction in tobacco consumption.Furthermore, the present high proportion of smokers among adult Danes will continue to affect the mortality pattern far into this century.Clearly, if it were not for tobacco, Danish women would have experienced a considerable reduction in mortality.
Abstract 17360: Four Factors Explain Most of the Gender Disparity in Statin Therapy
Authors: Huabing Zhang, Jorge Plutzky, Maria Shubina, Alexander Turchin
Journal: Circulation (2014)

Despite well documented gender disparities in statin therapy, the reasons underlying these differences remain obscure. Applying natural language processing to a retrospective cohort of 24,338 patients with coronary artery disease (CAD) treated in primary care practices (PCP) affiliated with two academic medical centers between 01/01/2000 and 12/31/2011, we studied contribution of smoking, age, cardiologist evaluation and adverse statin reactions to gender differences in statin use. Two thirds of the patients were men (Table); 85.6% received statins during the study period and 69.7% had persistent statin therapy (active statin prescription at the last PCP visit). Women were less likely than men to have been treated with a statin but equally likely to have persistent statin therapy after statin initiation. Women were older, less likely to have ever smoked, less likely to have been seen by a cardiologist and more likely to have reported an adverse reaction to a statin. In multivariable analysis of all subjects, patients with history of smoking (OR 1.304), younger age (OR 1.016), or cardiologist evaluation (OR 1.797) were more likely (p &lt; 0.001 for all) to have persistent statin therapy. Direct estimations of the effect of the differences in joint distributions of the covariates between men and women showed the following contributions to gender differences in persistent statin therapy: age 51.7%, smoking 31.5%, cardiologist evaluation 24.2%, and adverse statin reactions 6.7%. Together, these four factors contributed 89.9% to the gender disparity in persistent statin therapy. In 24,000 patients in whom statin therapy was clearly indicated, several specific factors appear to underlie differences in statin therapy and it’s persistent use between men and women. Identifying such drivers may facilitate interventions and further research to overcome gender differences in applying proven interventions for cardiovascular risk reduction.
Saliva Cortisol and Exposure to Aircraft Noise in Six European Countries
Authors: Jenny Selander, Gösta Bluhm, Töres Theorell, Göran Pershagen, Wolfgang Babisch, Ingeburg Seiffert, Danny Houthuijs, Oscar Breugelmans, Federica Vigna-Taglianti, Maria Chiara Antoniotti, Emmanuel Velonakis, Elli Davou, Marie-Louise Dudley, Lars Järup
Journal: Environmental Health Perspectives (2009)

BackgroundSeveral studies show an association between exposure to aircraft or road traffic noise and cardiovascular effects, which may be mediated by a noise-induced release of stress hormones.ObjectiveOur objective was to assess saliva cortisol concentration in relation to exposure to aircraft noise.MethodA multicenter cross-sectional study, HYENA (Hypertension and Exposure to Noise near Airports), comprising 4,861 persons was carried out in six European countries. In a subgroup of 439 study participants, selected to enhance the contrast in exposure to aircraft noise, saliva cortisol was assessed three times (morning, lunch, and evening) during 1 day.ResultsWe observed an elevation of 6.07 nmol/L [95% confidence interval (CI), 2.32–9.81 nmol/L] in morning saliva cortisol level in women exposed to aircraft noise at an average 24-hr sound level (LAeq,24h) > 60 dB, compared with women exposed to LAeq,24h ≤ 50 dB, corresponding to an increase of 34%. Employment status appeared to modify the response. We found no association between noise exposure and saliva cortisol levels in men.ConclusionsOur results suggest that exposure to aircraft noise increases morning saliva cortisol levels in women, which could be of relevance for noise-related cardiovascular effects.