Chlorthalidone Versus Hydrochlorothiazide
Authors: Robert G. Badgett
Journal: Annals of Internal Medicine (2013)

Letters18 June 2013Chlorthalidone Versus HydrochlorothiazideRobert G. Badgett, MDRobert G. Badgett, MDFrom Kansas University School of Medicine–Wichita, Wichita, Kansas.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-158-12-201306180-00016 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:I appreciate that Dhalla and colleagues (1) have revisited a long-standing conflict in the management of hypertension. However, I have several concerns about their analysis. First, the relative importance of the primary and secondary outcomes is not clear. The primary outcome is stated as death or hospitalization “for” a major cardiac event. The secondary outcome is hospitalization “with” an electrolyte abnormality.The primary outcome is important and clear, but can the authors provide more detail about the secondary outcome? For example, if a patient is hospitalized for appendicitis and the admitting physician lists hypokalemia as a secondary ...References1. Dhalla IA, Gomes T, Yao Z, Nagge J, Persaud N, Hellings C, et al. Chlorthalidone versus hydrochlorothiazide for the treatment of hypertension in older adults: a population-based cohort study. Ann Intern Med. 2013;158:447-55. [PMID: 23552325] LinkGoogle Scholar2. Juurlink DN, Mamdani MM, Lee DS, Kopp A, Austin PC, Laupacis A, et al. Rates of hyperkalemia after publication of the Randomized Aldactone Evaluation Study. N Engl J Med. 2004;351:543-51. [PMID: 15295047] CrossrefMedlineGoogle Scholar3. Goldfarb DS. Hyperkalemia after the publication of RALES [Letter]. N Engl J Med. 2004;351:2448-50. [PMID: 15575065] CrossrefMedlineGoogle Scholar Author, Article, and Disclosure InformationAuthors: Robert G. Badgett, MDAffiliations: From Kansas University School of Medicine–Wichita, Wichita, Kansas.Disclosures: None disclosed. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoChlorthalidone Versus Hydrochlorothiazide for the Treatment of Hypertension in Older Adults Irfan A. Dhalla , Tara Gomes , Zhan Yao , Jeff Nagge , Navindra Persaud , Chelsea Hellings , Muhammad M. Mamdani , and David N. Juurlink Chlorthalidone Versus Hydrochlorothiazide Alberto Donzelli Chlorthalidone Versus Hydrochlorothiazide Paula T. Einhorn , William C. Cushman , Paul K. Whelton , and Chlorthalidone Versus Hydrochlorothiazide Irfan A. Dhalla , Muhammad M. Mamdani , and David N. Juurlink Chlorthalidone Versus Hydrochlorothiazide George C. Roush , Theodore R. Holford , and Achuta K. Guddati Chlorthalidone Versus Hydrochlorothiazide James J. DiNicolantonio , James H. O'Keefe , and Carl J. Lavie Metrics Cited byChlorthalidone Versus Hydrochlorothiazide in Hypertension Treatment: Do We Have the Evidence to Decide? 18 June 2013Volume 158, Issue 12Page: 921KeywordsAppendicitisConflicts of interestDiureticsDrugsHospitalizationsHypertensionPotassium ePublished: 18 June 2013 Issue Published: 18 June 2013 Copyright & PermissionsCopyright © 2013 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...