tbuckley/cabot-search huggingface dataset:
THE EAR IN "STUNT" FLYING
Authors: LEWIS FISHER
Journal: JAMA (1918)

Crashes that occur during "stunt" flying are usually the result of something having gone wrong with the pilot. Hence, it is a pertinent matter for medical investigation. Just what this something is, is not always clear. Poor judgment, a sense of bravado, carelessness, "stunting" at low altitudes, and sudden faintness are among the reasons generally offered in explanation of these accidents. Direct testimony of the pilot is not always available, since many of the crashes result fatally. Neither are pilots who have crashed and survived always able to give a clear and concise account or analysis of the causes of the accident. Underlying them all, however, there runs a story of momentary loss of faculties, resulting in a manipulation of controls without deliberate judgment. Most accounts of crashes read, "The pilot went into a tail spin and failed to come out." The story of Lieut. J. M. M. is quite
Idiopathic tumefactive chronic pancreatitis: Clinical profile, histology, and natural history after resection
Authors: Dhiraj Yadav, Kenji Notahara, Thomas C. Smyrk, Jonathan E. Clain, Randall K. Pearson, Michael B. Farnell, Suresh T. Chari
Journal: Clinical Gastroenterology and Hepatology (2003)
Rates of Major Depressive Disorder and Clinical Outcomes Following Traumatic Brain Injury
Authors: Charles H. Bombardier, Jesse R. Fann, Nancy R. Temkin, Peter C. Esselman, Jason Barber, Sureyya S. Dikmen
Journal: JAMA (2010)

<h3>Context</h3>Uncertainties exist about the rates, predictors, and outcomes of major depressive disorder (MDD) among individuals with traumatic brain injury (TBI).<h3>Objective</h3>To describe MDD-related rates, predictors, outcomes, and treatment during the first year after TBI.<h3>Design</h3>Cohort from June 2001 through March 2005 followed up by structured telephone interviews at months 1 through 6, 8, 10, and 12 (data collection ending February 2006).<h3>Setting</h3>Harborview Medical Center, a level I trauma center in Seattle, Washington.<h3>Participants</h3>Five hundred fifty-nine consecutively hospitalized adults with complicated mild to severe TBI.<h3>Main Outcome Measures</h3>The Patient Health Questionnaire (PHQ) depression and anxiety modules were administered at each assessment and the European Quality of Life measure was given at 12 months.<h3>Results</h3>Two hundred ninety-seven of 559 patients (53.1%) met criteria for MDD at least once in the follow-up period. Point prevalences ranged between 31% at 1 month and 21% at 6 months. In a multivariate model, risk of MDD after TBI was associated with MDD at the time of injury (risk ratio [RR], 1.62; 95% confidence interval [CI], 1.37-1.91), history of MDD prior to injury (but not at the time of injury) (RR, 1.54; 95% CI, 1.31-1.82), age (RR, 0.61; 95% CI, 0.44-0.83 for ≥60 years vs 18-29 years), and lifetime alcohol dependence (RR, 1.34; 95% CI, 1.14-1.57). Those with MDD were more likely to report comorbid anxiety disorders after TBI than those without MDD (60% vs 7%; RR, 8.77; 95% CI, 5.56-13.83). Only 44% of those with MDD received antidepressants or counseling. After adjusting for predictors of MDD, persons with MDD reported lower quality of life at 1 year compared with the nondepressed group.<h3>Conclusions</h3>Among a cohort of patients hospitalized for TBI, 53.1% met criteria for MDD during the first year after TBI. Major depressive disorder was associated with history of MDD and was an independent predictor of poorer health-related quality of life.
CONSTRUCTIVE HEALTH ACTIVITIES IN PUBLIC SCHOOLS
Authors: JOHN SUNDWALL
Journal: JAMA (1923)

<h3>IMPORTANCE OF SCHOOL HEALTH ACTIVITIES</h3> The most far-reaching results to be anticipated in our nation-wide health movement will come from effective health activities in our schools—in our grade schools, high schools and universities. Especially is this true for our public schools. The impressions of childhood and the habits formed in early life are tenacious. Ingrain in our boys and girls health habits; correct physical conditions which are actual or potential handicaps; give them, by means of appropriate, wisely planned and graded instruction throughout their school period, an understanding of the fundamental principles of health promotion and disease prevention; instil in them a keen and impelling appreciation of the fact that the maintenance of sound, active, vigorous and harmoniously developed bodies is a moral obligation they owe to themselves, to their friends, to society and to their country; acquaint them with the methods and facilities at our command for promoting health
Transient dysaesthesiae and persistent leucocytosis after clioquinol therapy.
Authors: S I Terry
Journal: BMJ (1971)

drome 26%' of cases where the haemoglobin was reported had polycythaemia, and 15% of cases diagnosed as androgenic tumours had a raised haemoglobin.The low cholesterol levels seen in this patient may be explained by the high androsterone levels.Androsterone when given intramuscularly has been shown to cause a sharp fall of plasma cholesterol (Mills, 1964), but the mechanism by which this occurs is unknown.The amenorrhoea associated with adrenal tumours is due to suppression of FSH, but it is interest- ing to note that the LH levels were exceedingly high. References
House of Clocks
Authors: Ted McMahon
Journal: JAMA (2009)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Concurrent hepatic adenomatoid tumor and hepatic hemangioma: a case report
Authors: Ji-Beom Kim, Eunsil Yu, Ju-Hyun Shim, Gi-Won Song, Gwang Un Kim, Young-Joo Jin, Ho-Seop Park
Journal: Clinical and Molecular Hepatology (2012)

A 45-year-old male with alleged asymptomatic hepatic hemangioma of 4 years duration had right upper-quadrant pain and was referred to a tertiary hospital. Computed tomography and magnetic resonance imaging scans revealed a hypervascular mass of about 7 cm containing intratumoral multilobulated cysts. A preoperative liver biopsy was performed, but this failed to provide a definitive diagnosis. The patient underwent a partial hepatectomy of segments IV and VIII. The histologic findings revealed multifocal proliferation of flattened or cuboidal epithelioid cells and a highly vascular edematous stroma. Immunohistochemistry findings demonstrated that the epithelioid tumor cells were positive for cytokeratin (AE1/AE3), vimentin, calretinin, and cytokeratin 5/6, and were focally positive for CD10, and negative for WT1 and CD34, all of which support their mesothelial origin. Immunohistochemistry for a mesothelial marker should be performed for determining the presence of an adenomatoid tumor when benign epithelioid cells are seen. Keywords: Adenomatoid tumor; Liver; Hemangioma
THE MOTOR MECHANISM OF THE GALLBLADDER
Authors: ASHER WINKELSTEIN
Journal: JAMA (1923)

The Meltzer-Lyon test for disease of the biliary tract has aroused a renewed interest in the motor mechanism of the gallbladder. Despite the large amount of research devoted to it, this phase of the physiology of the gallbladder remains quite obscure. I was convinced of this during some experimental studies on the excretion of foreign-body dyestuffs in the gastro-intestinal tract which I carried on in Professor Bickel's biologic laboratory in the University of Berlin.  It was found that the secretion in the bile of a subcutaneously injected dyestuff, specifically indigocarmin, was entirely ended in from eight to fifteen hours in a complete gallbladder fistula dog (i. e., one with the ductus choledochus ligated), while in a normal dog, not operated on, indigocarmin-colored bile remained in the gallbladder from four to five days. At the end of two weeks, the bile in the gallbladder was found uncolored by the dye. (The
Qualitative and quantitative contributions of the T cell receptor zeta chain to mature T cell apoptosis.
Authors: B Combadière, M Freedman, L Chen, E W Shores, P Love, M J Lenardo
Journal: The Journal of Experimental Medicine (1996)

Engagement of the T cell receptor (TCR) of mature T lymphocytes can lead either to activation/proliferation responses or programmed cell death. To understand the molecular regulation of these two fundamentally different outcomes of TCR signaling, we investigated the participation of various components of the TCR-CD3 complex. We found that the TCR-zeta chain, while not absolutely required, was especially effective at promoting mature T cell apoptosis compared with the CD3 epsilon, gamma, or delta chains. We also carried out mutagenesis to address the role of the immunoreceptor tyrosine-based activation motifs (ITAMs) that are the principal signaling components found three times in the TCR-zeta chain and once in each of the CD3 epsilon, gamma, or delta chains. We found that the ability of the TCR-zeta chain to promote apoptosis results both from a quantitative effect of the presence of multiple ITAMs as well as qualitatively different contributions made by individual ITAMs. Apoptosis induced by single chain chimeras revealed that the first zeta ITAM stimulated greater apoptosis than the third zeta ITAM, and the second zeta ITAM was unable to trigger apoptosis. Because microheterogeneity in the amino acid sequence of the various ITAM motifs found in the TCR-zeta and CD3 chains predicts interactions with distinct src-homology-2-domain signaling proteins, our results suggest the possibility that individual ITAM motifs might play unique roles in TCR responses by engaging specific signaling pathways.
INTRAPERITONEAL LOSS OF A DIALYSIS CATHETER
Authors: MARTIN F. STEIN
Journal: Annals of Internal Medicine (1969)

Letters and Comments1 October 1969INTRAPERITONEAL LOSS OF A DIALYSIS CATHETERMARTIN F. STEIN JR., M.D.MARTIN F. STEIN JR., M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-71-4-869 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the Editor: This letter was prompted by the unexpected postmortem finding of a dialysis catheter within the peritoneal cavity of a dialysis patient. The catheter had been in this site for 16 months without causing symptoms or complications. This report may be of value in the management of future similar cases.A 65-year-old woman was admitted to the hospital on September 20, 1967, for treatment of uremia. She had small kidneys and a creatinine clearance of 4.5 ml/min.The first peritoneal dialysis was begun on October 9, 1967, by insertion of an Abbott peritoneal dialysis catheter through a paracentesis...References1. WESTONROBERTS REM: Clinical use of a stylet catheter for peritoneal dialysis. Arch. Intern. Med. (Chicago) 115: 659, 1965. CrossrefMedlineGoogle Scholar2. SMITHCHAMBERLAIN EKMJ: Complication of peritoneal dialysis (correspondence). Brit. Med. J. 1: 126, 1965. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Hemodialysis Division St. Joseph's Hospital Yonkers, N. Y. 10701 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byPeritoneal Dialysis Access and Exit-Site Care Including Surgical AspectsPeritoneal dialysis access and exit-site care including surgical aspectsPeritoneal Catheter Placement and ManagementPeritoneal dialysis access and exit site carePeritoneal Dialysis AccessComplications of peritoneal dialysis other than peritonitisPeritoneal CathetersComplications of Peritoneal Dialysis Other Than PeritonitisPeritoneal DialysisLaparoscopic Retrieval of Dialysis CatheterCONSTANTIN COPE, M.D., F.A.C.P., MARK S. KRAMER, M.D. 1 October 1969Volume 71, Issue 4Page: 869-870KeywordsCathetersCreatinineForecastingKidneysMedical dialysisPeritoneal dialysis ePublished: 1 December 2008 Issue Published: 1 October 1969 PDF downloadLoading ...
Effects of single ethanol administration on hepatic ornithine decarboxylase induction and polyamine metabolism
Authors: Takashi Tanaka, Yoshihiro Sukegawa, Shuhei Nishiguchi, Tetsuo Kuroki, Kenzo Kobayashi, Isao Matsui-Yuasa, Shuzo Otani, Takashi Toda, Takeyuki Monna
Journal: Hepatology (1991)

The effects of a single ethanol administration on ornithine decarboxylase induction, polyamine metabolism and DNA synthesis in rat liver after partial hepatectomy were studied. Ethanol given 1 hr before partial hepatectomy at the dose of 2, 3 or 5 gm/kg body wt inhibited the increase in ornithine decarboxylase activity and that in the putrescine level in the liver 4 hr after partial hepatectomy. The hepatectomy increased the amount of ornithine decarboxylase messenger RNA expressed, and this amount was unaffected by ethanol administration. Further, ethanol did not accelerate the degradation of ornithine decarboxylase 4 hr after partial hepatectomy, indicating that the inhibition of ornithine decarboxylase activity caused by ethanol was not caused by a decrease in the ornithine decarboxylase messenger RNA level or by the acceleration of ODC degradation. The single dose of ethanol inhibited [ 3 H]thymidine incorporation into the hepatic DNA 24 hr after partial hepatectomy. The suppression of [ 3 H]thymidine incorporation was partially reversed by the administration of putrescine. These results suggested that ethanol inhibits the increase in ornithine decarboxylase activity after transcription, suppressing the accumulation of putrescine, which prevents DNA synthesis in response to hepatectomy. (Hepatology 1991;14:696-700.)
Prominence of Patients' Insurance Status in Clinical Crossroads
Authors: Robert J. Amdur
Journal: JAMA (1998)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
A phase 1 study evaluating the safety and tolerability of otlertuzumab, an anti-CD37 mono-specific ADAPTIR therapeutic protein in chronic lymphocytic leukemia
Authors: John C. Byrd, John M. Pagel, Farrukh T. Awan, Andres Forero, Ian W. Flinn, Delva P. Deauna-Limayo, Stephen E. Spurgeon, Leslie A. Andritsos, Ajay K. Gopal, John P. Leonard, Amy J. Eisenfeld, Jeannette E. Bannink, Scott C. Stromatt, Richard R. Furman
Journal: Blood (2014)
ESTABLISHING THE LINKS BETWEEN THE SOLUBLE RECEPTOR FOR ADVANCED GLYCATION END PRODUCTS, ASYMMETRIC DIMETHYLARGININE AND LOW-GRADE INFLAMMATION IN ESSENTIAL HYPERTENSION
Authors: Konstantinos P. Tsioufis, Kyriakos Dimitriadis, Costas Thomopoulos, Dimitris Syrseloudis, Antigoni Miliou, Kostas Toutouzas, Elli Stefanadi, Dimitris Tousoulis, Christodoulos Stefanadis
Journal: Journal of the American College of Cardiology (2010)
Medical Management of the Regional Musculoskeletal Diseases: Backache, Neck Pain, Disorders of the Upper and Lower Extremities
Authors: George E. Ehrlich
Journal: JAMA (1985)

The subtitle of this book explains its compass. Arthritis is not excluded, as the section on the hand and wrist obviously has to pay attention to osteoarthritic lesions and rheumatoid arthritis. Arthritis is not the focus of the book, however; soft-tissue lesions are.  The ubiquitous backache naturally leads the way. A major public health problem, it will afflict at least seven of every ten of our population. It has a multiplicity of causes and has been treated with standard measures and some that are either suspect or controversial, including many that have never been subjected to controlled study. Manipulation is discussed intelligently, as are chemonucleolysis and many other procedures, culminating in the way the author approaches backache.  As Dr Hadler rightly indicts, low back pain stands as a reproach to clinical investigation. It is the leading cause of absenteeism from industry... responsible for an extraordinary percentage of compensable injuries and
Chimpanzees are not proto-hominins and early human mothers may not have foraged alone
Authors: Agustín Fuentes
Journal: Behavioral and Brain Sciences (2004)

Modeling the evolution of human behavior, including language, is a complex but important undertaking. The over-reliance on chimpanzees as models to assess basal hominin patterns and the implicit assumption that hominin mothers did not have significant assistance in caring for young weaken this model for the emergence of language from mother-infant vocal interactions.
The Fastnet Race 1979.
Authors: B O'Donnell
Journal: BMJ (1980)

We now have in Ireland what we least need: a new group of bores. They will be known as Fastnet bores. I have a vision of my son, then aged 15, propping up the club bar in 50 years' time with a foot firmly on the rail and a gin and tonic in his hand and telling them You don't know what it was like?it was hell out there. The Fastnet race in 1979 showed that sailing is not an absolutely safe sport. The 1979 race was the 18th biennial race since 1925 and up to then there had only been one race death. Some 302 boats started; their length varied between 30 and 80 feet (9 and 24 m), but the great majority were between 30 and 44 feet (9 and 13 m) long. We were in our 37-foot (11 m) pro duction cruiser/racer Sundowner. We were not one of the 85 who finished but one of the 194 who retired. Twenty-three boats were abandoned, and of these five were lost. Fifteen people died. Nobody died in a boat that was sunk. A total of 173 people were taken aboard other boats or rescued by helicopter.
Marijuana and Paraquat
Authors: Carlton E. Turner
Journal: JAMA (1978)

To the Editor.—  Because of the news coverage of paraquat and marijuana, we wish to (1) report some data on Cannabis sativa L contaminated with the herbicide paraquat (1,1′dimethyl-4,4′ -dipyridilium dichloride) and (2) present some facts regarding marijuana with or without paraquat that will be useful to the medical science community.  In late 1975 Mexico initiated a program to eradicate cannabis by spraying illicit fields with aqueous paraquat. 1 In theory this was subsequently to reduce the flow of crude drugs from cannabis. This program was intensified in 1976. It is estimated that 36 million Americans have tried marijuana 2 ; thus, any agent used chemically to control cannabis is important to a large segment of our society and medical scientists.  In September 1977 we were requested by the National Institute of Drug Abuse (NIDA) to screen confiscated Mexican cannabis for paraquat. To this end, 100 samples of kilogram bricks of cannabis
Acyl-CoA:Cholesterol Acyltransferase Inhibition Reduces Atherosclerosis in Apolipoprotein E–Deficient Mice
Authors: Jun Kusunoki, Dipal K. Hansoty, Katsumi Aragane, John T. Fallon, Juan J. Badimon, Edward A. Fisher
Journal: Circulation (2001)

Background —Acyl-CoA:cholesterol acyltransferase (ACAT) converts cholesterol to cholesteryl esters. The form of ACAT in macrophages, ACAT1, contributes to foam cell formation in the arterial wall and the development of atherosclerosis. Recent studies in a mouse model of atherosclerosis (the apolipoprotein E [apoE]–deficient mouse), however, have suggested that complete deficiency of ACAT1 activity is not antiatherogenic, in part because of toxicity resulting from adverse effects on tissue cholesterol homeostasis. We have tested whether partial inhibition of ACAT1 and ACAT2 (expressed in liver and intestine) activities reduces atherosclerosis development in apoE-deficient mice and avoids toxicity. Methods and Results —ApoE-deficient mice were maintained for 17 weeks on a Western-type diet without (control) or with the ACAT inhibitor F-1394 (effective against ACAT1 and ACAT2) at doses of either 300 (low) or 900 (high) mg/kg. Intimal lesion area at the aortic sinus in controls was 0.69±0.06 mm 2 . F-1394 treatment significantly decreased lesional area by 39% (low) or 45% (high). F-1394 treatment also reduced lesional immunostaining for macrophages by 61% (low) or 83% (high). En face analysis showed that surface lipid staining in control aortas was 20.0±2.8%; F-1394 treatment reduced this by 46% (low) or 62% (high). There were no obvious signs of systemic or vessel wall toxicity associated with F-1394 treatment. Conclusions —Partial ACAT inhibition by F-1394 had antiatherogenic effects in apoE-deficient mice that were achieved without obvious toxicity. Partial ACAT inhibition may have therapeutic potential in the clinical treatment of atherosclerosis.
Propranolol for acute migraine.
Authors: R Tokola, E Hokkanen
Journal: BMJ (1978)

unwittingly vaccinated over the past 10 years unprotected against polio?If so, shall we have to reimmunise all these children previously given oral polio vaccine, and if not why all the present fuss ?To jab or not to jab-that is the question.Could we please havc some answers?
Women doctors are better communicators
Authors: J. H. Tanne
Journal: BMJ (2002)

Women doctors in the United States spend more time with their patients, talk with them more, establish more emotional rapport, and involve patients more in their treatment than male doctors, says a meta-analysis by researchers at Johns Hopkins Bloomberg School of Public Health in Baltimore and Northeastern University in Boston.

“The most important consequence of the difference is what it inspires in patients responding back to the doctor,” said lead author Dr Debra Roter a public health specialist at Johns Hopkins. “They are …