tbuckley/cabot-search huggingface dataset:
Abstract P215: Associations of Yerba Mate Tea Drinking With Blood Lipids, Apolipoproteins, and C-Reactive Protein Among South American Adults
Authors: Natalia Elorriaga, Rosana Poggio, Laura Gutierrez, Vilma E Irazola, Maria D Defago, Gabriela Corrmick, Goodarz Danaei, Dariush Mozaffarian, Adolfo L Rubinstein
Journal: Circulation (2015)

Background: Yerba mate tea, made from tree leaves of Ilex paraguariensis, is a widely consumed beverage in South America. Animal studies have reported improvement in serum lipids parameters and reduction in cholesterol content and size of aortic lesions with consumption of ilex paraguariensis extracts, that contain potentially bioactive saponin, phenolic compounds and methilxanthines. Few studies have been conducted in humans, mostly pilot studies. Evidence on the association between mate tea consumption and lipid profile, Apolipoprotein (Apo) AI, Apo B and C-reactive protein (CRP) in humans are sparse. We assessed these associations among adults from Argentina, Chile and Uruguay. Methods: CESCAS I (Center of Excellence in Cardiovascular Health of South America Study I) study is an observational population-based prospective cohort study of 7,600 participants from general population of four cities in the three countries. We conducted a cross-sectional analysis in a randomly selected subsample of 988 subjects aged 35 to 74 years. Participants with previous cardiovascular events or receiving lipid-lowering agents were excluded. Mate consumption and other dietary habits were assessed using a previously validated 126-item food frequency questionnaire. Multivariable linear regression models were used to examine the associations between Apo AI, B, CRP, and other lipids by tertiles (T) of mate tea consumption. The models adjusted for age, smoking status, body mass index, physical activity, alcohol intake, ‘prudent’ or ‘Western’ diet-pattern scores (identified by principal component analysis), added sugar to the mate, and presence of diabetes. Results: The sample included 418 men and 570 women. The proportion of mate drinkers (at least once a month during last year) were 40% in Temuco (Chile), 84% in Canelones (Uruguay), 89% in Marcos Paz and 91% in Bariloche (Argentina). Median mate intake across tertiles was 0, 590 and 1875ml/day in men and 0, 625 and 1875ml/day in women, respectively. Higher mate consumption (T3 vs. T1) was independently associated with higher levels of Apo AI in both men (5.1mg/L, 95% CI, 0.1 to 10.1) and women (6.7mg/L, 95% CI, 1.5 to 11.9). In men higher mate consumption was also associated with lower levels of triglycerides (-49mg/dL, 95% CI, -11 to -86) and in women with slightly lower Apo B/AI ratio (-0.05, 95% CI, -0.001 to -0.06). Differences in total cholesterol, HDL cholesterol, LDL cholesterol, Apo B, and CRP were not statistically significant. Conclusions: Among generally healthy adults, higher consumption of mate during the past 12 months was associated with higher levels of APO-A1 in both men and women, and with lower triglycerides levels in men.
Diabetic endothelial dysfunction: the role of poly(ADP-ribose) polymerase activation
Authors: Francisco Garcia Soriano, László Virág, Prakash Jagtap, Éva Szabó, Jon G. Mabley, Lucas Liaudet, Anita Marton, Dale G. Hoyt, Kanneganti G. K. Murthy, Andrew L. Salzman, Garry J. Southan, Csaba Szabó
Journal: Nature Medicine (2001)
SURGICAL ASPECTS OF OCCLUSIVE DISEASE OF THE AORTA AND ILIAC ARTERIES
Authors: A W HUMPHRIES, V G DEWOLFE, F A LEFEVRE, R C BRITTON
Journal: Annals of Internal Medicine (1959)

Article1 October 1959SURGICAL ASPECTS OF OCCLUSIVE DISEASE OF THE AORTA AND ILIAC ARTERIESALFRED W. HUMPHRIES, M.D., VICTOR G. DEWOLFE, M.D., F.A.C.P., FAY A. LEFEVRE, M.D., F.A.C.P., R. C. BRITTON, M.D.ALFRED W. HUMPHRIES, M.D.Search for more papers by this author, VICTOR G. DEWOLFE, M.D., F.A.C.P.Search for more papers by this author, FAY A. LEFEVRE, M.D., F.A.C.P.Search for more papers by this author, R. C. BRITTON, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-51-4-686 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptIt is our purpose in this brief paper to present the current philosophy of the medicosurgical vascular team of the Cleveland Clinic regarding angioplastic procedures on the major peripheral vessels.Experience with 750 arterial grafts has led to certain criteria which we follow in selecting candidates for arterial surgery. Although these criteria are subject to modification at any time, they establish our philosophy concerning arterial grafts at the present time. Thrombo-endarterectomy is occasionally done, particularly for carotid and renal stenosis, but most patients operated upon for arterial disease at the Cleveland Clinic have received either a homograft or a Dacron... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Cleveland, Ohio*Received for publication July 2, 1959.Presented at the Fortieth Annual Session of The American College of Physicians, Chicago, Illinois, April 24, 1959.From the Department of Vascular Surgery and the Department of Cardiovascular Disease, The Cleveland Clinic Foundation and The Frank E. Bunts Educational Institute, Cleveland, Ohio.Requests for reprints should be addressed to Alfred W. Humphries, M.D., Frank E. Bunts Educational Institute, Cleveland Clinic Foundation, Cleveland, Ohio. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 October 1959Volume 51, Issue 4Page: 686-697KeywordsAnginaArteriesCardiovascular diseasesHomograftsIschemiaRenal diseasesStenosisSurgeryUlcersVascular surgery ePublished: 1 December 2008 Issue Published: 1 October 1959 PDF downloadLoading ...
Justice Department attempts to override Oregon's Death With Dignity Act
Authors: Charles Marwick
Journal: BMJ (2003)

This article originally appeared in BMJ USA 

In early November, when Attorney General John Ashcroft issued an order authorizing legal action against physicians who intentionally prescribe lethal drugs for terminally ill patients to assist in their suicide—thus effectively overruling Oregon's Death With Dignity Act—the outcry was predictable. Those opposed to physician-assisted suicide applauded; supporters of “death with dignity” were vocal in their criticism.

For example, Fred Richardson, board chairman of the Hemlock Society, wrote a letter to President George W Bush protesting the action. The Society's President, Faye Girsh, described the order as “an unfortunate step backward.” Subsequently, at a press conference, the Society charged that Ashcroft was denying hopelessly ill individuals “the option of a peaceful, dignified death.” The Hemlock Society, based in Denver, Colorado, is one of the largest activist groups promoting the concept of “death with dignity.”

Ashcroft's action, published in the November 9, 2001, Federal Register , is nationwide in its effect; however, its critics maintain that it is aimed squarely at Oregon's Death With Dignity Act. Under the …
X-linked neonatal diabetes mellitus, enteropathy and endocrinopathy syndrome is the human equivalent of mouse scurfy
Authors: Robert S. Wildin, Fred Ramsdell, Jane Peake, Francesca Faravelli, Jean-Laurent Casanova, Neil Buist, Ephrat Levy-Lahad, Massimo Mazzella, Olivier Goulet, Lucia Perroni, Franca Dagna Bricarelli, Geoffrey Byrne, Mark McEuen, Sean Proll, Mark Appleby, Mary E. Brunkow
Journal: Nature Genetics (2001)
Erratum to “BDNF gene-modified mesenchymal stem cells promote functional recovery and reduce infarct size in the rat middle cerebral artery occlusion model” [Molecular Therapy 9: 189–197 (2004), doi:10.1016/j.ymthe.2003.10.012]
Authors: Kazuhiko Kurozumi, Kiminori Nakamura, Takashi Tamiya, Yutaka Kawano, Masayoshi Kobune, Sachie Hirai, Hiroaki Uchida, Katsunori Sasaki, Yoshinori Ito, Kazunori Kato, Osamu Honmou, Kiyohiro Houkin, Isao Date, Hirofumi Hamada
Journal: Molecular Therapy (2004)

The publisher regrets that several corrections requested by the authors were not completed. On page 190, in Fig. 2A, the P value between DMEM and MSC-BDNF on Day 8 is incorrect. It should read “P = 0.0001.” On page 191, in Fig. 3A, the y-axis label should read “Infarction volume (%).” On page 194, right-hand column, lines 11 and 12 should read “…high levels of integrin αv [32] ….” On page 197, reference 43 should read “Koizumi, J., Yoshida, Y., Nakazawa, T., and Ooneda, G. (1986). Experimental studies of ischemic brain edema. 1. A new experimental model of cerebral embolism in rats in which recirculation can be induced in the ischemic area. Jpn. J. Stroke 8: 1–7.” BDNF Gene-Modified Mesenchymal Stem Cells Promote Functional Recovery and Reduce Infarct Size in the Rat Middle Cerebral Artery Occlusion ModelKurozumi et al.Molecular TherapyFebruary, 2004In BriefExamination of the clinical therapeutic efficacy of using bone marrow stromal cells, including mesenchymal stem cells (MSC), has recently been the focus of much investigation. MSC were reported to ameliorate functional deficits after stroke in rats, with some of this improvement possibly resulting from the action of cytokines secreted by these cells. To enhance such cytokine effects, we transfected telomerized human MSC with the BDNF gene using a fiber-mutant F/RGD adenovirus vector and investigated whether these cells contributed to improved functional recovery in a rat transient middle cerebral artery occlusion (MCAO) model. Full-Text PDF Open Archive
"Morning after" sun cream may prevent skin cancers
Authors: D. Josefson
Journal: BMJ (2001)

A topical cream with the potential to prevent skin cancers by reversing damage to DNA may one day be as widely available as sunscreen lotion.

It also promises to serve as a “morning after” solution, as it can be used to reverse damage on a molecular level after a person has been sunburnt — although a health expert in the UK has questioned whether this might encourage people to ignore health messages about safe sun exposure.

The cream uses a bacterial enzyme, T4 endonuclease, to identify, snip away, and repair fused pyrimidine base pairs in DNA, which frequently result from exposure to ultraviolet light. Their accumulation causes mutations that lead to premalignant skin lesions, such as actinic keratoses, and to tumours of …
Infliximab therapy induces increased polyclonality of CD4+CD25+ regulatory T cells in psoriasis
Authors: L. Diluvio, M.L. Romiti, F. Angelini, E. Campione, P. Rossi, J.C. Prinz, S. Chimenti, A. Lamioni
Journal: British Journal of Dermatology (2010)

Journal Article Infliximab therapy induces increased polyclonality of CD4+CD25+ regulatory T cells in psoriasis Get access L. Diluvio, L. Diluvio Departments of Dermatology Search for other works by this author on: Oxford Academic Google Scholar M.L. Romiti, M.L. Romiti Pediatrics, University of Rome 'Tor Vergata', 00133 Rome, Italy Search for other works by this author on: Oxford Academic Google Scholar F. Angelini, F. Angelini Pediatrics, University of Rome 'Tor Vergata', 00133 Rome, ItalyDivision of Immunology and Infectious Diseases, Children's Hospital Bambino Gesù, Rome, Italy Search for other works by this author on: Oxford Academic Google Scholar E. Campione, E. Campione Departments of Dermatology Search for other works by this author on: Oxford Academic Google Scholar P. Rossi, P. Rossi Pediatrics, University of Rome 'Tor Vergata', 00133 Rome, ItalyDivision of Immunology and Infectious Diseases, Children's Hospital Bambino Gesù, Rome, Italy Search for other works by this author on: Oxford Academic Google Scholar J.C. Prinz, J.C. Prinz Department of Dermatology, Ludwig‐Maximilians University of Munich, Munich, Germany Search for other works by this author on: Oxford Academic Google Scholar S. Chimenti, S. Chimenti Departments of Dermatology Search for other works by this author on: Oxford Academic Google Scholar A. Lamioni A. Lamioni Associazione Nazionale Microcitemie Italia (ANMI ONLUS), Rome, Italy E‐mail: lauradiluvio@yahoo.it Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 162, Issue 4, 1 April 2010, Pages 895–897, https://doi.org/10.1111/j.1365-2133.2010.09650.x Published: 01 April 2010
28. A Clinically Relevant Ex Vivo Toxicity Assay Using Human Liver Slices To Determine Specificity of Oncolytic Viruses
Authors: Roisin M. Dwyer, Elizabeth R. Bergert, Michael K. O'Connor, Sandra J. Gendler, John C. Morris
Journal: Molecular Therapy (2004)

The sodium iodide symporter (NIS) is a transmembrane glycoprotein responsible for the uptake of iodide into cells. Robust NIS expression in the thyroid gland provides for effective imaging and non-invasive treatment of thyroid disease using radioactive iodide. Gene therapy involving selective induction of NIS expression in other tumors offers the possibility of imaging and treating a variety of tumor types with radioactive iodide. We have recently reported in vitro, plasmid-mediated expression of NIS under the control of the MUC1 promoter in a variety of tumor cell lines. Since MUC1 is overexpressed in many tumor types, particularly breast cancer, this promoter provides the ability to selectively target tumor tissue. In this study, a replication-deficient adenoviral construct containing the MUC1-NIS insert was used to induce iodide uptake in breast cancer xenografts. Subcutaneous T47D breast cancer xenografts were established on both flanks of athymic nude mice. When they had reached an appropriate volume, intratumoral injections of Ad5/MUC1/NIS or control virus were administered. Mice were then given an intra-peritoneal injection of either 0.5mCi 123I (imaging) or 3mCi 131I (therapy). Scanning with a gamma camera revealed clear images of iodide uptake in the mouse stomach, thyroid and bladder, as well as at the site of the tumors injected with Ad5/MUC1/NIS. Tumors injected with the promoter-less Ad5/NIS did not take up iodide. Mice treated with 131I showed a marked regression in tumor size within one week of iodide administration, with tumor volume reduced by 50% within three weeks. Tumors that had been injected with control virus did not express NIS, and retained their original volume or increased in size. These preliminary in vivo experiments demonstrate that the Ad5/MUC1/NIS construct is capable of inducing robust NIS expression and iodide uptake in MUC1 positive breast tumor xenografts. This may have potential applications for the imaging and treatment of a variety of MUC1-positive tumor types.
Physicians on Twitter
Authors: Katherine C Chretien, Justin Azar, Terry Kind
Journal: JAMA (2011)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
South Africa legislates to extend private health insurance
Authors: Pat Sidley
Journal: BMJ (2000)

Private health care in South Africa is due for a radical overhaul as the new Medical Schemes Act comes into force. The new law—intended to change the face of medical insurance in the country—was passed at the end of 1998, but its regulations come into effect only this month.

A likely consequence of the act—and tougher economic circumstances—will be the more visible appearance of managed care in South African. With this in mind, the government has included regulations on managed care to avoid some of the pitfalls of the US system.

The new law has been designed to ensure that more …
Fluid Accumulation during Initial Stages of Ascites Tumor Growth
Authors: Robert L. Straube
Journal: Cancer Research (1958)

1.  The presence of Ehrlich ascites tumor cells in the peritoneal cavity of the mouse leads to an increased intraperitoneal accumulation of intravenously administered I131-labeled protein. This change can be demonstrated within 30 minutes after the inoculation of the tumor cells.

2.  The amount of labeled material accumulated is a function of the number of tumor cells inoculated, over the range of 2–20 × 106 cells. There is an increase of 0.25 per cent of total injected activity at 1 hour after inoculation for every 106 tumor cells.

3.  This accumulation is a local phenomenon, involving only the peritoneal cavity. Cell-free ascitic fluid alone does not induce such extra accumulation, nor do injected hepatic cells. A similar, but transient, effect can be induced by the nonspecific cellular irritant, Fuller's earth.

4.  Tumor cells lysed with distilled water are also incapable of this effect. It would seem, therefore, that the whole, and presumably living, tumor cell must be present to induce this accumulation.

5.  The presence of Ehrlich ascites tumor cells in the peritoneal cavity of the mouse leads to a small but significant retention there of I131-labeled serum protein after its intraperitoneal injection.

6.  Partial blockade of the lymphatics by carbon particles significantly increases the amount of labeled protein accumulated in the peritoneal cavity of normal mice, but does not increase the amount of activity accumulated by tumor-bearing animals.

7.  The liver lymphatics apparently do not contribute appreciably to the increased accumulation of labeled protein in the peritoneal cavity in the presence of ascites tumor cells; accumulation of label is within normal limits in tumor-bearing mice after removal of 70 per cent of the liver.

8.  The arguments for attributing ascitic fluid accumulation to lymphatic blockade and possible mechanisms for such blockade are discussed.
Abstract 13122: Prevalence and Predictors of Lapses in Care in Adults With Congenital Heart Disease (Health, Education And Access Research Trial, Heart-ACHD)
Authors: Michelle Gurvitz, Amy Verstappen, Anne Marie Valente, Craig Broberg, Stephen Cook, Karen Stout, Joseph Kay, Jennifer Ting, Karen Kuehl, Michael Earing, Gary Webb, Linda Houser, Alexander Opotowsky, Dionne Graham, Paul Khairy, Michael Landzberg
Journal: Circulation (2011)

Background: Adults with congenital heart disease (ACHD) are at risk for interruptions in care. We undertook a prospective multi-center study, a main objective of which was to quantify the prevalenc...
Abstract #LB-279: Differential impact of EpCAM on cancer invasion in barest and gastrointestinal cancers in association with altered AP-1 and C-myc transcriptional activity
Authors: Narendra Sankpal, Mike Willman, John Mayfield, Timothy Fleming, William Gillanders
Journal: Cancer Research (2009)

EpCAM is a cell-surface glycoprotein that is overexpressed in the majority of epithelial cancers. However, the functional role of EpCAM in the process of neoplastic transformation remains unclear. The literature is inconsistent, with in vitro studies demonstrating that EpCAM expression is associated with either increased or decreased invasion depending on the cancer type. Further, EpCAM expression in primary tumor specimens as measured by immunohistochemistry is associated with either favorable or unfavorable prognosis depending on the cancer type. To study the role of EpCAM in cancer invasion in more detail, we manipulated EpCAM expression in loss-of-function and gain-of-function studies and demonstrate that EpCAM expression is directly correlated with invasion in breast cancer cells, and inversely correlated with invasion in gastrointestinal cancer cells. In parallel studies using luciferase-based pathway reporter constructs, we demonstrate that EpCAM expression is differentially associated with AP-1, Myc, and NF-KB transcriptional activity (increased in breast cancer cells, and decreased in gastrointestinal cancer cells). Finally, gene expression profiling and confirmatory real-time RT-PCR analyses demonstrate concomitant and differential alterations in the transcriptional activity of a number of several known AP-1 and Myc target genes involved in cancer invasion including EGFR, ARPC1B, DNMT1 and MMP1. Taken together, these data are the first demonstration that EpCAM expression can influence AP-1 and NF-KB transcriptional activity, and strongly suggest that the differential impact of EpCAM on cancer invasion is mediated through these transcriptional factors. These data also have important implications for the application of molecular therapies that are currently under development targeting EpCAM in epithelial carcinomas.   Citation Information:  In: Proc Am Assoc Cancer Res; 2009 Apr 18-22; Denver, CO. Philadelphia (PA): AACR; 2009. Abstract nr LB-279.
Abstract 13878: Smooth Muscle-specific IGF-1 Receptor Deficiency Increases Atherosclerosis and Promotes Features of Unstable Plaque
Authors: Shaw-Yung Shai, Sergiy Sukhanov, Yusuke Higashi, Veronica J D’Ambra, Thomas C Woods, Patrice Delafontaine
Journal: Circulation (2014)

Insulin-like growth factor I (IGF-1) has pleiotropic effects, stimulating growth, differentiation, survival and anabolism, in multiple tissues and cell types including smooth muscle cells (SMC). Although IGF-1 is a SMC mitogen, we have previously shown that systemic IGF-1 infusion reduces atherosclerosis in Apoe-null mice. To determine the role of SMC IGF-1 receptor (IGF-1R) signaling in atherogenesis, we generated SMC-specific IGF-1R/Apoe-double knockout mice (22KO) by crossing floxed IGF-1R mice (FIR) with mice expressing Cre recombinase under control of the SM22α promoter. 22KO mice had >80% reduction in aortic IGF-1R expression vs. FIR mice, no change in serum IGF-1 levels (22KO: 325.99±24.24 ng/ml vs FIR: 348.11±18.79 ng/ml, P=NS), reduced body weight (15±3% decrease, p<0.05) and weight of SMC-rich organs (urinary bladder, 37±4% decrease; aorta, 18±2% decrease, p<0.05), thinner aortic wall media (40±5% decrease, p<0.05), reduced size of individual aortic SMC (23±3% decrease, P<0.05) without a change ...
Antiallergic drugs and the immune response
Authors: G. W. Canonica, G. Ciprandi
Journal: Allergy (1989)

Since the pharmacological treatment of allergic diseases is used in patients with alteration of the immune response due to atopy and possible concomitant infections, we have investigated the possible effects of such drugs as cromolyn, theophylline, ketotifen, oxatomide, astemizole, fenoterol, pirenzepine, and rosaprostol on the in vitro immune response, in order to obtain experimental data and, as a consequence, clinical conclusions. In a series of investigations by our group and other authors the following immunological parameters have been considered: T cell activation induced by different pathways (i.e. autologous stimulation, PHA, anti‐CD3, ‐CD2 and ‐CD28 monoclonal antibodies), and lymphokine production (i.e. IL‐1, IL‐2 and gamma‐IFN). For a more detailed experimental model the experiments have been performed both in bulk culture and by using T cell clones derived from the peripheral blood. The results show cromolyn to have an enhancing effect, theophylline and ketotifen a suppressing effect, whereas the remainder show no effect on the immune response. These data are considered and discussed from the aspect of their possible clinical relevance and also in light of the in vivo data previously reported.