tbuckley/cabot-search huggingface dataset:
A healthy tension in translational research
Authors: Harry Dietz
Journal: Journal of Clinical Investigation (2014)

I would like to express my sincere appreciation to the American Society for Clinical Investigation and the Harrington Discovery Institute for the honor of being named the inaugural recipient of the Harrington Prize for Innovation in Medicine. I accept this distinction with a deep sense of gratitude and debt to my mentors, trainees, colleagues, collaborators, patients, and family. Moments of recognition such as this are rare, savored, and sustaining. They also invariably provoke personal reflection about what exactly is being recognized. If something innovative truly stands apart in my work, I have come to the conclusion that it relates less to the methods utilized to address questions and more to the questions I choose to ask, and when I ask them.
INTESTINAL PERFORATION IN TYPHOID FEVER; ITS DIAGNOSIS AND SURGICAL TREATMENT.
Authors: J. E. ALLABEN
Journal: JAMA (1907)

If it were necessary that one should make an apology for offering a contribution on this subject, I should say that it has been twenty-three years since Leyden first proposed the surgical treatment of this malady and Mikulicz did the first successful operation, giving to humanity the first ray of hope in a contest where death was well nigh inevitable. A year and a half ago I lost my own son from this accident. Had I made as careful a study of the diagnosis of perforation in typhoid before his illness as I have made since, I think his life might have been saved. And so I feel somewhat like the rich man, the story of whom is told in sacred history, who, languishing in eternal punishment, looked up to Lazarus in the bosom of Abraham and implored him, if he could not come to him and ease his suffering
Ventricular Fibrillation, Hypokalemia, and AMSA Therapy
Authors: JOSEPH A. FOLDES
Journal: Annals of Internal Medicine (1982)

Letters and Corrections1 January 1982Ventricular Fibrillation, Hypokalemia, and AMSA TherapyJOSEPH A. FOLDES, M.D., YORAM YAGIL, M.D., ABRAHAM KORNBERG, M.D.JOSEPH A. FOLDES, M.D.Search for more papers by this author, YORAM YAGIL, M.D.Search for more papers by this author, ABRAHAM KORNBERG, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-96-1-121_2 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: We read with interest the article on 4'-(9-acridinylamino) methanesulfon-m-Anisidide (AMSA) by Legha and associates (1). Although ventricular fibrillation was mentioned as a possible complication of using AMSA for acute adult leukemia, no practical conclusions were drawn on the cause or possible prevention of this complication. We recently treated a patient with acute lymphoblastic leukemia who developed ventricular fibrillation during AMSA therapy, in whom the arrhythmia was clearly related to concurrent hypokalemia. We believe this case may contribute to our understanding of the causal interrelation of AMSA, hypokalemia, and the occurrence of cardiac arrhythmia.A 28-year-old woman with...References1. LEGHAKEATINGZANDERMCCREDIEBODEYFREIREICH SMAKGE. 4'-(9-acridinylamino) methanesulfon-M-Anisidide (ASMA): a new drug effective in the treatment of adult acute leukemia. Ann Intern Med. 1980;93:17-21. LinkGoogle Scholar2. CABANILLASLEGHABODEYFREIREICH FSGE. Initial experience with AMSA as single agent treatment against malignant lymphoproliferative disorders. Blood. 1981;57:614-6. CrossrefMedlineGoogle Scholar3. ARLINSKLAROFFGEE ZRT. Phase I and II trial of AMSA in patients with acute leukemia. Cancer Res. 1980;40:3304-6. MedlineGoogle Scholar4. VON HOFFELSONPOLKCOLTMAN DDGC. Acute ventricular fibrillation and death during infusion of m-AMSA. Cancer Treat Rep. 1980;64:356-7. MedlineGoogle Scholar5. LEGHALATREILLEMCCREDIE SJK. Neurological and cardiac rhythm abnormalities associated with AMSA therapy. Cancer Treat Rep. 1979;63:2001-3. MedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Hadassah University Hospital-Mt. Scopus il-91240 Jerusalem Israel PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByOBSOLETE: Arrhythmias in Cancer and Cancer Treatment: A ReviewArrhythmias in Cancer and Cancer Treatment: A ReviewCardiotoxicity of Chemotherapeutic AgentsAmsacrine EvaluationTreatment of acute leukaemia with m-AMSA in combination with cytosine arabinosideAmsacrine: A reviewTHE EFFECTS OF m-AMSA ON RAT ISOLATED HEARTCardiotoxicity study of amsacrine in ratsElectrocardiogram abnormalities induced by amsacrine 1 January 1982Volume 96, Issue 1Page: 121-122KeywordsArrhythmiaPrecursor cellsVentricular fibrillation Issue Published: 1 January 1982 PDF DownloadLoading ...
A Punch-Card Laboratory Reporting System With a Cumulative Summary Format
Authors: John M. Walsh
Journal: JAMA (1969)

A laboratory reporting system has been developed in a 500-bed community hospital which processes approximately 40,000 tests a month. The patient's chemistry and hematology data are updated daily in a cumulative summary format. This daily summary updates and replaces previous summaries in that calendar week. The summary format proves particularly valuable for serial determinations. This review of the daily reports permits the pathologist closer control of laboratory data while giving him a more active role with the clinician in data interpretation. The system offers many of the advantages of automated laboratory data processing for hospitals already equipped with punch-card systems. Pick-up lists, laboratory work schedules, interim ward reports, charges, and statistical reports are also produced.
Maternal and Fetal Outcomes of Subsequent Pregnancies in Women with Peripartum Cardiomyopathy
Authors: Uri Elkayam, Padmini P. Tummala, Kalpana Rao, Mohammed W. Akhter, Ilyas S. Karaalp, Omar R. Wani, Afshan Hameed, Israel Gviazda, Avraham Shotan
Journal: New England Journal of Medicine (2001)

Peripartum cardiomyopathy is a rare and sometimes fatal form of heart failure. Little is known about the outcomes of subsequent pregnancies in women who have had the disorder.Through a survey of members of the American College of Cardiology, we identified 44 women who had had peripartum cardiomyopathy and had a total of 60 subsequent pregnancies. We then reviewed the medical records of these women and interviewed the women or their physicians.Among the first subsequent pregnancies in the 44 women, 28 occurred in women in whom left ventricular function had returned to normal (group 1) and 16 occurred in women with persistent left ventricular dysfunction (group 2). The pregnancies were associated with a reduction in the mean (+/-SD) left ventricular ejection fraction both in the total cohort (from 49+/-12 percent to 42+/-13 percent, P<0.001) and in each group separately (from 56+/-7 percent to 49+/-10 percent in group 1, P=0.002; and from 36+/-9 percent to 32+/-11 percent in group 2, P=0.08). During these pregnancies, a decrease of more than 20 percent in the left ventricular ejection fraction occurred in 21 percent of the women in group 1 and 25 percent of those in group 2, and symptoms of heart failure occurred in 21 percent of the women in group 1 and 44 percent of those in group 2. The mortality rate was 0 percent in group 1 and 19 percent in group 2 (P=0.06). In addition, the frequency of premature delivery was higher in group 2 (37 percent vs. 11 percent), as was that of therapeutic abortions (25 percent vs. 4 percent).Subsequent pregnancy in women with a history of peripartum cardiomyopathy is associated with a significant decrease in left ventricular function and can result in clinical deterioration and even death.
Salih Yassin Salih
Authors: I. Fahal
Journal: BMJ (2009)

Professor Salih Yassin Salih was a lifelong advocate of medical education, an inspiring teacher, a medical writer, and a humble person.

He was born in Omdurman on 27 September 1942, and educated at Omdurman schools and the faculty of medicine, University of Khartoum. He graduated in 1968 after a very distinguished undergraduate career. He held house appointments in Khartoum before becoming a research assistant in medicine in the University of Khartoum and a medical registrar at Khartoum civil hospital in September 1969. He then received a …
Human Cell Culture Rabies Vaccine
Authors: Tadeusz J. Wiktor
Journal: JAMA (1973)

A new tissue culture rabies vaccine was administered to 16 human volunteers, eight of whom had previously received other rabies vaccines. In the latter group there was an excellent booster antibody response. In the group with no previous vaccination, five of the eight subjects developed antibodies after one inoculation, and seven of the eight after two inoculations. Antibody titers after two inoculations were similar to those previously reported in the literature after 14 inoculations of duck embryo. Only minimal local reactions and no general reactions to the vaccine were noted.
Lack of arterial hypervascularity at contrast-enhanced ultrasound should not define the priority for diagnostic work-up of nodules &lt;2cm
Authors: Alejandro Forner, Ramón Vilana, Luis Bianchi, Carlos Rodríguez-Lope, María Reig, M. Ángeles García-Criado, Jordi Rimola, Manel Solé, Carmen Ayuso, Concepció Bru, Jordi Bruix
Journal: Journal of Hepatology (2014)
CAN CLOPIDOGREL LOADING (600MG) BE ADMINISTERED &lt;2 HOURS PRE-PCI IN PATIENTS PRESENTING WITH ACUTE CORONARY SYNDROMES?
Authors: Dmitriy N. Feldman, Luke K. Kim, Robert M. Minutello, Geoffrey Bergman, Issam Moussa, S. Chiu Wong
Journal: Journal of the American College of Cardiology (2010)
Insulin, Glucose, Insulin Resistance, and Incident Colorectal Cancer in Male Smokers
Authors: Paul J. Limburg, Rachael Z. Stolzenberg-Solomon, Robert A. Vierkant, Katherine Roberts, Thomas A. Sellers, Philip R. Taylor, Jarmo Virtamo, James R. Cerhan, Demetrius Albanes
Journal: Clinical Gastroenterology and Hepatology (2006)
Autophagy Regulates Phagocytosis by Modulating the Expression of Scavenger Receptors
Authors: Diana L. Bonilla, Abhisek Bhattacharya, Youbao Sha, Yi Xu, Qian Xiang, Arshad Kan, Chinnaswamy Jagannath, Masaaki Komatsu, N. Tony Eissa
Journal: Immunity (2013)
Erythropoietin — An Endogenous Retinal Survival Factor
Authors: S Patricia Becerra, Juan Amaral
Journal: New England Journal of Medicine (2002)

Apoptosis causes the death of photoreceptors in macular degeneration and retinitis pigmentosa and the death of retinal ganglion cells in glaucoma. Receptors for erythropoietin are present in both types of cells, and in mice, erythropoietin blocks light-induced apoptosis of these cells. Erythropoietin has potential as a treatment for degenerative retinal diseases.
India launches major programme to treat burn injuries
Authors: D. Sachan
Journal: BMJ (2014)

A committee of cabinet ministers in India has approved a fully fledged national programme for the prevention and management of burn injuries.

The government set up the programme as a pilot project in 2011 after years of lobbying by the National Academy of Burns India. The campaign was spearheaded by J L Gupta, the former head of the department of plastic surgery, burns, and maxillofacial surgery at Safdarjang Hospital in New Delhi. The national programme will be implemented over the remaining period of the government’s 12th five year plan (2012-17).

The academy has estimated that around seven …
The Anatomy of Bright's Disease
Authors: P. W. Swain
Journal: BMJ (1872)

THE BRITISH MEDICAL JOUR7NAL.une 22, I872.may therefore become so slow in the particular part as to allow of the formation of a small coagulum of fibrin or a thrombosis; there would then be complete obstruction, and consequently the greatest possible pressure would be brought to bear on the arterial wall, and result very probably in rupture.In this way not only may cerebral apoplexy be accounted for, but pulmonary apoplexy and apoplexies in the kidneys and spleen, or hemorrhagic infarctions, occurring in cases where no en- docardiac or valvular mischief has existed.The same explanation may be offered with respect to cedema of the integument and dropsy, as is given for cedema of the lungs.A characteristic of the cedema in Bright's disease is that it changes its position, now attacking one organ, now another.How is this?And why does the morbidly altered blood cause contraction of the minute arteries; is it by direct contact with the vessel, or is this the result of the action of the blood on the ganglionic cells of the nervous system ?These are interesting questions still requiring explanation.
Ultrasound in Evaluating Renal Masses
Authors: Philip B. Kivitz
Journal: JAMA (1976)

<h3>To the Editor.—</h3> The recent letter by Dr Judith Everett (235:2813, 1976) does not accurately reflect the use of diagnostic ultrasound for the evaluation of renal masses. It is generally accepted that homogeneous tumors, of which hypernephroma is one, may superficially mimic a cyst pattern. Subtle differences may be noted in "back wall" characteristics as well as internal structure. However, to discover the group of lesions that masquerade as cysts, aspiration is strongly recommended to alleviate the need for arteriography and surgery for benign cystic lesions. The aspirate should be sent for appropriate laboratory testing, including cytologic examination. At the time of aspiration, positive contrast may be instilled into the cyst and radiographic examination of the cyst wall contour performed as an added measure in doubtful cases. I feel it is unjust to condemn an entire modality on the basis of a single case. There was no mention made as
Differential pattern of CCR1 internalization in human eosinophils: prolonged internalization by CCL5 in contrast to CCL3
Authors: J. Elsner, Y. Dulkys, S. Gupta, S. E. Escher, W.‐G. Forssmann, A. Kapp, U. Forssmann
Journal: Allergy (2005)

Background: Whereas recent studies underlie the fundamental importance of the CC chemokine receptor 3 (CCR3) for the recruitment of eosinophils in allergic diseases, controversial data exist about the relevance of CCR1 on eosinophils. Therefore, the purpose of this study was to investigate the expression and regulation of CCR1 on eosinophils. Methods: Flow cytometric analysis of whole blood eosinophils and CD16‐negative selected eosinophils from healthy nonatopic donors and from patients with atopic disorders was performed and CCR1 receptor internalization and re‐expression were studied. Results: Flow cytometric analysis of whole blood eosinophils revealed that 17.8% of the donors expressed high levels of CCR1 (CCR1 high ) and 82.2% low levels of CCR1 (CCR1 low ). A significant down‐regulation of CCR1 was induced by 24 h preincubation of isolated eosinophils from CCR1 high donors either with IL‐3, CC chemokine ligand 3 (CCL3), CCL5, CCL7, or CCL13. Internalization experiments using eosinophils from CCR1 high donors revealed that CCL5 is more effective to induce CCR1 internalization than CCL3. Whereas CCR1 re‐expression after stimulation with CCL3 reached prestimulation levels (120 min: 81.3% relative CCR1 surface expression) CCL5 induced a prolonged CCR1 internalization (120 min: 15.7%). Conclusions: This study demonstrates a distinct pattern of CCR1 internalization and re‐expression in human eosinophils between CCL3 and CCL5, as CCL5 induces a prolonged CCR1 internalization and the basic value is not reached after 24 h. Since prolonged receptor internalization plays a central role in chemokine‐mediated inhibition of receptor function, CCR1 seems to be an attractive target on human eosinophils for chemokine receptor blockade besides CCR3.
Regulation of Neuronal Traits by a Novel Transcriptional Complex
Authors: Nurit Ballas, Elena Battaglioli, Fouad Atouf, Maria E. Andres, Josh Chenoweth, Mary E. Anderson, Corinna Burger, Mariko Moniwa, James R. Davie, William J. Bowers, Howard J. Federoff, David W. Rose, Michael G. Rosenfeld, Paul Brehm, Gail Mandel
Journal: Neuron (2001)
A COMMON GROUND FOR MEDICINE AND DENTISTRY.
Authors: FRANK L. PLATT
Journal: JAMA (1905)

The recognition of dentistry as a specialty of medicine by the American Medical Association and the International Medical Congresses, marks one of the happiest epochs in the history of both professions, for it has opened the way for a mutual understanding of conditions and study of theories beneficial to both, and destined to promote in no small degree the health and happiness of the human race. The goal of both professions is practically identical, embracing as it does, all honorable means for the relief of suffering and for the cure and prevention of disease. Within comparatively few years, the medical profession has made giant strides in preventing epidemics of plague, cholera, yellow fever and malaria, and is to-day waging a relentless war, and one which will ultimately be successful, against the greatest of all scourges, tuberculosis. Dentistry is no unworthy member of the great medical family, and many of its
Noninvasive Imaging of Therapeutic Gene Expression Using a Bidirectional Transcriptional Amplification Strategy
Authors: Sunetra Ray, Ramasamy Paulmurugan, Manish R Patel, Byeong C Ahn, Lily Wu, Michael Carey, Sanjiv S Gambhir
Journal: Molecular Therapy (2008)

Promoters that limit transgene expression to tumors play a vital role in cancer gene therapy. Although tumor specific, the human Survivin promoter (pSurv) elicits low levels of transcription. A bidirectional two-step transcriptional amplification (TSTA) system was designed to enhance expression of the therapeutic gene (TG) tumor necrosis factor-alpha-related apoptosis-inducing ligand (TRAIL or TR) and the reporter gene firefly luciferase (FL) from pSurv. An adenoviral vector carrying the enhanced targeting apparatus (Ad-pSurv-TR-G8-FL) was tested for efficiency and specificity of gene expression in cells and in living animals. Compared to the one-step systems (Ad-pSurv-FL or Ad-pSurv-TR), the bidirectional TSTA system showed tenfold higher expression of both the therapeutic and the reporter gene and their expression correlated in cells (R(2) = 0.99) and in animals (R(2) = 0.67). Noninvasive quantitative monitoring of magnitude and time variation of TRAIL gene expression was feasible by bioluminescence imaging of the transcriptionally linked FL gene in xenograft tumors following intratumoral adenoviral injection. Moreover, the TSTA adenovirus maintained promoter specificity in nontarget tissues following tail vein administration. These studies demonstrate the potential of the bidirectional TSTA system to achieve high levels of gene expression from a weak promoter, while preserving specificity and the ability to image expression of the TG noninvasively.
Biomaterials and Herniology
Authors: Stanley D. Berliner
Journal: JAMA (1984)

<h3>To the Editor.—</h3> The participants at the Conference on the Clinical Applications of Biomaterials held at the National Institutes of Health were "charged with addressing the area of greatest clinical need in which the state of the art today is feasible and practical."<sup>1</sup>Their report cited biomaterial applications in cardiovascular surgery, plastic surgery, orthopedics, neurosurgery, ophthalmology, otolaryngology, nephrology, and urology. There was no mention of mesh prostheses for groin and other abdominal wall hernias—a serious omission. Groin herniorrhaphy is the third most common primary operative procedure. Adult inguinal herniorrhaphy constitutes 15% of general surgical operations.<sup>2</sup>A proper hernial repair implies an anatomic reconstruction without tension so that collagen synthesis can reestablish a stable aponeurotic structure. In some cases the tissue quality is so poor or the hernial defect so large that a biomaterial is needed to bridge the gap. From January 1980 through September 1983, I found it
Opiate withdrawal and botulism: stigma delayed treatment
Authors: K. Marlowe
Journal: BMJ (2003)

EDITOR—Merrison et al reported a difficult diagnostic case of wound botulism, which led to the formulation of a helpful diagnostic table for distinguishing clinical features from Guillain-Barre syndrome, Miller-Fisher variant, and myasthenia gravis.1 I report a case of wound botulism in a long term heroin user showing that a history of substance misuse can cloud the picture even more than the clinical presentation.

A man with a 20 …
Proportion of US Adults Potentially Affected by the 2014 Hypertension Guideline
Authors: Ann Marie Navar-Boggan, Michael J. Pencina, Ken Williams, Allan D. Sniderman, Eric D. Peterson
Journal: JAMA (2014)

The new 2014 blood pressure (BP) guideline released by the panel members appointed to the Eighth Joint National Committee (JNC 8; 2014 BP guideline) proposed less restrictive BP targets for adults aged 60 years or older and for those with diabetes and chronic kidney disease. OBJECTIVETo estimate the proportion of US adults potentially affected by recent changes in recommendations for management of hypertension.DESIGN Cross-sectional, nationally representative survey.PARTICIPANTS Using data from the National Health and Nutrition Examination Survey between 2005 and 2010 (n = 16 372), we evaluated hypertension control and treatment recommendations for US adults.MAIN OUTCOMES AND MEASURES Proportion of adults estimated to meet guideline-based BP targets under the 2014 BP guideline and under the previous seventh Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure (JNC 7) guideline. RESULTSThe proportion of younger adults (18-59 years) with treatment-eligible hypertension under the JNC 7 guideline was 20.3% (95% CI, 19.1%-21.4%)and decreased to 19.2% (95% CI, 18.1%-20.4%)under the 2014 BP guideline.Larger declines were observed among older adults (Ն60 years), decreasing from 68.9% (95% CI, 66.9%-70.8%)under JNC 7 to 61.2% (95% CI, 59.3%-63.0%)under the 2014 BP guideline.The proportion of adults with treatment-eligible hypertension who met BP goals increased slightly for younger adults, from 41.2% (95% CI, 38.1%-44.3%)under JNC 7 to 47.5% (95% CI, 44.4%-50.6%)under the 2014 BP guideline, and more substantially for older adults, from 40.0% (95% CI, 37.8%-42.3%)under JNC 7 to 65.8% (95% CI, 63.7%-67.9%)under the 2014 BP guideline.Overall, 1.6% (95% CI, 1.3%-1.9%) of US adults aged 18-59 years and 27.6% (95% CI, 25.9%-29.3%) of adults aged 60 years or older were receiving BP-lowering medication and meeting more stringent JNC 7 targets.These patients may be eligible for less stringent or no BP therapy with the 2014 BP guideline.CONCLUSIONS AND RELEVANCE Compared with the JNC 7 guideline, the 2014 BP guideline from the panel members appointed to the JNC 8 was associated with a reduction in the proportion of US adults recommended for hypertension treatment and a substantial increase in the proportion of adults considered to have achieved goal BP, primarily in older adults.