tbuckley/cabot-search huggingface dataset:
Abstract 4426: Contemporary Below-the-Knee and Femoral-Popliteal Percutaneous Arterial Intervention: A Comparison of Procedural Outcomes and Predictors of Success - Insights From the Blue Cross Blue Shield of Michigan Cardiovascular Consortium (BMC2 -PVI)
Authors: Paul M Grossman, Christos Kasapis, Khan Munir, David Share, Stanley J Chetcuti, Timothy J Nypaver, Paul Bove, Herbert D Aronow, Hitinder S Gurm
Journal: Circulation (2009)

Background: Percutaneous vascular intervention (PVI) techniques for revascularization of symptomatic infra-inguinal peripheral arterial disease (PAD) are increasingly utilized as the preferred method of revascularization. However, the in-hospital outcomes and predictors of procedural success for both femoral-popliteal (FP) and below-the-knee (BTK) PVIs are unknown.  Methods: Data were analyzed from 10,099 consecutive PVI cases collected between 2003 through 2008 in a prospective, multi-center, multi-disciplinary regional database. Patients who underwent infra-inguinal PVI (FP or BTK) were included. Technical success was defined as completion of the PVI with   Results: A total of 5608 patients were included in the analysis, 4750 (84.7%) underwent FP PVI and 858 (15.3%) underwent BTK PVI. Patient and procedural characteristics are shown in Table 1. Patients undergoing BTK PVI were more likely to receive post-PVI transfusion (6.4% vs. 8.8, p  Conclusions: Contemporary infra-inguinal PVI is marked by high procedural success and low complication rates. Predictors of procedural failure in this cohort included advanced age, vessel calcification, total vessel occlusion and BTK disease. These data may help inform patients and clinicians when determining the optimal revascularization approach for severe infra-inguinal PAD.
Hospitals' major incident plans worked well
Authors: Roger Dobson
Journal: BMJ (1999)

London hospitals treated more than 100 casualties from the train crash that occurred near Paddington last week. The Chelsea and Westminster Hospital and St Mary's Hospital dealt with most of the cases, but Charing Cross, Central Middlesex, and University College Hospitals were also involved; paramedics treated over 130 people at the scene of the rail crash.

Major incident plans at both Chelsea and Westminster, and St Mary's …
Positive and negative regulation of granulocyte-macrophage colony- stimulating factor promoter activity by AML1-related transcription factor, PEBP2
Authors: A Takahashi, M Satake, Y Yamaguchi-Iwai, SC Bae, J Lu, M Maruyama, YW Zhang, H Oka, N Arai, K Arai
Journal: Blood (1995)
Multiplexed in situ analysis of protein expression to predict response to trastuzumab
Authors: Jena Giltnane, Annette Molinaro, Andrew Robinson, Dmitry Turbin, Karen Gelmon, David Huntsman, David Rimm
Journal: Cancer Research (2007)

5028   HER-2 belongs to a family of four Type I tyrosine kinase receptors, including EGFR, HER-3, and HER-4, that homo- and hetero-dimerize to activate distinct cellular programs. In breast cancer, this receptor family also demonstrates cross-talk with the hormone receptors for estrogen (ER) and progesterone (PR). Trastuzumab is an antibody-based targeted therapy effective in less than half of the patients that over express HER-2. We hypothesize that assessment of other HER2 family members and related markers could more specifically classify patients and define responders to the therapy. In this study, we quantitatively assessed the expression of ER, PR, and the four HER family proteins in four subcellular compartments using automated quantitative analysis (AQUA), a novel, immunofluorescence-based quantitative method of measuring protein expression in situ.  	Multiplexing was tested for both prognostic and predictive value. We used unsupervised hierarchical clustering to assess prognostic value in the archival Yale breast cohort (n=656). Six classes were identified, including a small class enriched for HER-2 expression. Disease specific survival of this class was compared to other HER-2 classification methods by Kaplan Meier analysis. The separation of classes by survival was optimal when multiple markers were considered, as the median survival for the HER-2 group dropped from 98 months in the IHC 3+ group, to 55 months for AQUA HER-2 positive, to 43 months for multiplexed clustering positive.  	To assess predictive value, individual, pair-wise, and multivariate logistic models were constructed with the data from expression of the six proteins in a trastuzumab-treated, retrospectively collected cohort (n=152) from the British Columbia Cancer Agency. Prediction error estimates for dichotomized outcome (complete/partial response vs. stable/progressive disease) were assessed with leave-one-out cross-validation and the corresponding intervals with bootstrap resampling. Using continuous AQUA scores, both low estrogen receptor expression (p=0.027) and high HER-2/neu (p=0.0007) expression were significantly associated with favorable clinical response. A multivariate model including ER, HER-2, EGFR, and HER4 had a misclassification estimate of 31.8% (95% CI 18.9%-44.7%), which was superior to any one protein, traditional IHC, or FISH for prediction of trastuzumab response.  	In summary, using AQUA, we found that combined analysis of ER, PR, and HER family members improved prognostic classification, and we developed a multivariate logistic model that optimized prediction for trastuzumab response in the metastatic setting. As trastuzumab treatment is extended to patients in the adjuvant setting, development of predictive methods such as these will be valuable to more accurately identify patients that will respond favorably to treatment.
非通常型心房粗動の根治により心不全症状が改善しtachycardia induced cardiomyopathyが考えられた一例
Authors: 荒川友晴, 内山達司, 可児篤, 渡辺英一, 杉浦厚司, 平光伸也, 森本紳一郎, 岩瀬正嗣, 菱田仁
Journal: Circulation (2002)
Classic and emergent forms of botulism: the current status in Italy
Authors: P Aureli, L Fenica, G Franciosa
Journal: Eurosurveillance (1999)

Botulism is a rare, severe, neuroparalytic disease. Four forms of botulism are described in humans: foodborne botulism and the more recently described wound botulism, infant botulism, and ‘infant-like’ botulism. The two last forms are sometimes grouped un
Dysregulation of distal cholesterol biosynthesis in association with relapse and advanced disease in CHC genotype 2 and 3 treated with sofosbuvir and ribavirin
Authors: Zobair M Younossi, Maria Stepanova, Michael Estep, Francesco Negro, Paul J Clark, Sharon Hunt, Qinghua Song, Matthew Paulson, Luisa M Stamm, Diana M Brainard, G Mani Subramanian, John G McHutchison, Keyur Patel
Journal: Journal of Hepatology (2015)
Abstract 19553: Changes of Plaque CT Densities Evaluated by MDCT Have Inverse Relationships with Changes of LDL/HDL Ratio and Triglyceride Levels
Authors: Tadashi Miyamoto, Sayaka Saijou, Mana Kawashima, Takuma Sawa, Takashi Kiyonaka, Taisuke Goto, Erika Yamamoto, Rei Fukuhara, Ryoji Taniguchi, Masanao Touma, Yukihito Sato, Yoshiki Takatsu, Hisayoshi Fujiwara
Journal: Circulation (2010)
Under Pressure
Authors: Michael E. Detsky, Meyer S. Balter, S. Kavita Sridhar, John Granton
Journal: New England Journal of Medicine (2010)

A 25-year-old woman presented to her local hospital with dyspnea. She described a 2-year history of progressive shortness of breath on exertion. Within the previous 3 days, her condition had deteriorated to the point that she was unable to leave her bedroom without having dyspnea.
Abstract 17741: Angiotensin II Enables Leukocyte/Endothelium Integrated Signaling Mechanisms That are Causative of Endothelial Dysfunction in Insulin Resistance
Authors: Rosario Scalia, Satoru Eguchi, Gavin Landesberg
Journal: Circulation (2011)

Recent studies have linked vascular AngII/AT1r signaling to the calcium-dependent protease µ-calpain. We have recently reported that activation of endothelial-expressed µ-calpain by AngII/AT1r signaling induces leukocyte-endothelium interactions in the post-capillary venules of the microcirculation. Accordingly, we hypothesized that: 1) AngII/calpain signaling impairs endothelium-dependent relaxation in the arterial system of the obese, insulin resistant Zucker Fatty (ZF) rat, and 2) neutrophil derived myeloperoxidase (MPO) synergizes with AngII/AT1r signaling to sustain calpain activation in the vascular wall of ZF rats. We used wire myography to study endothelium-dependent relaxation and vascular reactivity of the rat and mouse aorta. Aortic rings isolated from ZF rats exhibited reduced endothelium-dependent relaxation to ACh and increased contractility to Norepinephrine (p&lt;0.01 versus control Lean Zucker (ZL) rats). Incubation of aortic rings with either 1-µm AT1r blocker losartan or 10-µM calpain inhibitor ZLLal restored endothelium-dependent relaxation in aortic rings from ZF rats (p&lt;0.05 versus untreated ZF aortic rings). Furthermore, endothelium-dependent relaxation to ACh was preserved in µ-calpain deficient mice fed a high-fat diet for 12 consecutive weeks. Plasma and aortic levels of MPO were also elevated in ZF rats (p&lt;0.01 versus ZL rats) and reduced by losartan treatment (p&lt;0.05 versus untreated ZF rat). Ex vivo studies demonstrated that AngII acutely induces MPO release from control neutrophils, a phenomenon that was prevented by pre-incubation of neutrophils with 1-µM Losartan. Biochemical studies in rat aortic endothelial cells confirmed that MPO significantly synergizes AngII/AT1r-induced calpain activation. Taken together our data demonstrate that AngII/AT1r signaling impairs endothelium-dependent relaxation in the obese, insulin resistant organism by a mechanism that implicates neutrophil-derived MPO and endothelial expressed calpain. These data uncover: 1) a novel integrative mechanisms responsible for hypertension in obesity with insulin resistance and 2) new molecular targets of the pleiotropic actions of AT1r blocker on the blood-vascular system.
Abstract 1137: Switch From Nitric Oxide To Hydrogen Peroxide Mediated Dilation In Coronary Arterioles Of Obese Rats
Authors: Marta Focardi, Marina Ziche, Mario Marzilli
Journal: Circulation (2007)

Background. Obesity is associated with coronary endothelial dysfunction, an early marker of atherosclerosis; but impaired endothelial function in obese Zucker rats appears not to be mediated by NO production. Hypothesis: We tested the hypothesis that endothelial derived hyperpolarizing factor (EDHF) is responsible for endothelial dilation in obese rats. Methods: We used 4 groups of male Zucker rats: lean and obese on normal and low carb diets. Rats were fed ad libitum for 3 weeks; caloric intake and weight gain were similar. Coronary arterioles were cannulated and pressurized for diameter measurements. Vasodilation to acetylcholine (Ach) and flow was determined before and after incubation with L-NAME (10 μm), an inhibitor of NO synthase, plus the cyclooxygenase inhibitor indomethacin (Indo; 10 μm), after tetraethylammonium (TEA 1 mM), a non-selective K + channel antagonist, and after catalase, a H 2 O 2 scavenger (CAT; 500 U/ml). Results Acetylcholine-induced vasodilation was impaired in obese rats compared to lean (41%; n=5 vs 87%; n=3; p&lt;0.05) and did not change after L-NAME+Indo incubation in obese both on normal (47 ± 19%; n = 4 vs . 40 ± 13%; n = 4; p =ns) and low carb diet (51 ± 1%; n = 3 vs . 59 ± 6%; n = 3; p =ns). Flow-induced dilation was impaired in obese rats compared to lean (38%;n=5 vs 78%; n=2;p&lt;0.05) and this dilation was not affected by L-NAME+Indo incubation in obese both on normal (45±12%; n=4 vs 48±10% n=4; p =ns) and low carb diet (53±14%; n=3 vs 61±12% n=3; p =ns). Importantly, TEA incubation decreased Ach dilation both in obese on normal (41±11%; n=5 vs 13±7% n=5; p&lt; 0.05) and low carb diet (76±25%; n=3 vs 22±18% n=3; p&lt; 0.05). Similar results were obtained during flow-induced dilation in obese both on normal (37±17%; n=5 vs 14±7% n=5; p&lt; 0.05) and low carb diet (54±14%; n=3 vs 15±3% n=3; p&lt; 0.05). Catalase administration blocked both FID and Ach dilation in obese both on normal (FID 45±15% vs 5±3% n=3; p&lt; 0.05; Ach 39±14% vs 12±5% n=3; p&lt;0.05) and low carb diet (FID 52±19% vs 18±7% n=2; p&lt; 0.05; Ach 75±35% vs 15±2% n=2; p&lt; 0.05). Conclusions: Endothelial dependent vasodilation of coronary arterioles in obese Zucker rats is mediated by H 2 O 2 and increases in endothelial function in obese rats on a low carb diet is mediated by increased H 2 O 2 -induced dilation.
Abstract 1247: Heart Function is Transiently Sustained Despite a Near Loss of SERCA2 Protein in Cardiomyocyte-specific <i>Serca2</i> <sup>null</sup> Mice
Authors: Kristin B Andersson, Alexandra V Finsen, Ivar Sjaastad, Yibin Wang, Ju Chen, Jeffery D Molkentin, Kenneth R Chien, Ole M Sejersted, Geir Christensen
Journal: Circulation (2007)

The SERCA2 Ca 2+ ATPase is of central importance for refilling of the sarcoplasmic reticulum (SR) Ca 2+ store and cardiac contractility. Reduced SERCA2 function is associated with heart failure. We hypothesized that loss of SERCA2 would result in immediate severe myocardial contractile dysfunction and death. Transgenic mice were generated with a Cre-loxP strategy in which tamoxifen induces Serca2 ( Atp2a2 ) gene excision in the cardiomyocytes (SERCA2KO) of adult mice. In SERCA2KO mice, SERCA2 protein was rapidly reduced in left ventricular myocardium with a half-life &lt; 3 days. After 4 weeks, SERCA2 protein was reduced to &lt; 5% of control values. In isolated cardiomyocytes, SERCA2a, SERCA2b, SERCA1 and SERCA3 proteins were not detectable. Strikingly, SERCA2KO mice did not present clinical signs of circulatory failure at 4 weeks. Fractional shortening was preserved, and cardiac output was reduced to 80% of control values. The left atrial diameter, lung weight and left ventricular end-diastolic pressure (LVEDP) were slightly increased in SERCA2KO mice compared with controls, and the maximal rates of pressure development and decline in the left ventricle were affected with a prolongation of the ventricular relaxation time. After seven weeks, SERCA2KO mice developed severe congestive heart failure with dilated chambers, elevated LVEDP and pronounced increases in lung and atrial weights. Cardiac output was reduced to 70% of control values. There were no indications of major cardiomyocyte disarray in the myocardium at the 4 or 7 week timepoints. The abundance of Na + ,Ca 2+ exchanger, L-type Ca 2+ channel 1c and alpha2delta1 subunit proteins and Pmca1 mRNA were all increased at 4 and 7 weeks. The expression of calsequestrin protein and Ryr2 mRNA were unchanged. L-type Ca 2+ channel alpha2delta1 subunit and PMCA1 expression were further enhanced at 7 weeks in SERCA2KO mice. Thus, cardiac function is supported in SERCA2KO mice for several weeks despite the near absence of SERCA2 protein. Alterations in the expression of Ca 2+ transporting proteins suggest that Ca 2+ transients are generated over the plasma membrane rather than the SR. However, the adaptations induced by loss of SERCA2 are not sufficient for long-term support of heart function in adult mice.
C-reactive protein as a predictor of coronary events and coronary artery disease prevalence, extent, or severity by coronary CT angiography
Authors: Edward Hulten, Marcio S Bittencourt, Brian Ghosshajra, Khurram Nasir, Suhny Abbara, Quynh A Truong, Thomas J Brady, Udo Hoffmann, Ron Blankstein
Journal: Circulation (2012)

Background. The association of C-reactive protein (CRP) with coronary calcium score, coronary artery disease (CAD) assessed by invasive angiography, and adverse coronary events has been studied with widely variable results. CRP as a predictor of Coronary Computed Tomography Angiographic (CCTA) findings and their association with downstream outcomes has not been extensively evaluated. Methods. Retrospective cohort of all CCTA scans at two large tertiary hospitals within Partners Healthcare system (Boston, Massachusetts) from Sep 2004 to Oct 2011. We included all consecutive patients > 18 years old without known prior CAD who underwent CCTA and CRP assessment within 6 months. Diagnostic performance of CRP for prediction of any CAD, >50% and >70% stenosis, Segment Stenosis Score (SSS), Segment Involvement Score (SIS) was evaluated using sensitivity (Se), specificity (Sp), area under receiver operating characteristic curve (AUC), and likelihood ratios (-LR and +LR). Survival analysis using Cox proportional ha...
Abstract 10807: Thymoglobulin Induction may Confer Survival Benefit in Younger African-American Patients: Review of the United Network for Organ Sharing Database
Authors: Bernice Coleman, Jignesh Patel, Lawrence Czer, James Mirocha, Jon Kobashigawa
Journal: Circulation (2012)

Purpose: Disparity in heart transplant outcomes between African Americans and Caucasian American patients is known. These differences may due to genetic differences in the metabolism of immunosuppr...
Follistatin-Like 1 Is a Novel Secreted Muscle Protein That Confers Cardiovascular Protection
Authors: Noriyuki Ouchi
Journal: Circulation (2008)

Abstract 485 Noriyuki Ouchi, Yuichi Oshima, Kenneth Walsh, Boston Univ Sch of Med, Boston, MA Noriyuki Ouchi, 2008 Finalist and Presenting Author
Evidence of long-term gene flow and selection during domestication from analyses of Eurasian wild and domestic pig genomes
Authors: Laurent A F Frantz, Joshua G Schraiber, Ole Madsen, Hendrik-Jan Megens, Alex Cagan, Mirte Bosse, Yogesh Paudel, Richard P M A Crooijmans, Greger Larson, Martien A M Groenen
Journal: Nature Genetics (2015)
老年人使用镇静催眠药、抗抑郁剂和苯二氮（艹卓）类药物显著增加跌倒风险
Authors: Sirpa, Hartikainen, Eija, Lonnroos, 李涛, 于欣
Journal: BMJ (2010)

跌倒是一种常见的老年科综合征，在老年人中发生率较高，对生活质量和残疾有重大影响，多种因素导致发生跌倒的风险。药代动力学和药效学方面年龄相关性改变，以及健康逐渐衰退，使老年人尤其容易发生药物副作用，包括跌倒。如果危险因素可以容易地被识别、改变，并且最好能够被避免的话，那么这些危险因素在临床实践中的意义就最为重要。药物使用通常满足这些标准。
Diagnostic Performance of 64-Multidetector Row Coronary Computed Tomographic Angiography for Evaluation of Coronary Artery Stenosis in Individuals Without Known Coronary Artery Disease
Authors: Matthew J. Budoff, David Dowe, James G. Jollis, Michael Gitter, John Sutherland, Edward Halamert, Markus Scherer, Raye Bellinger, Arthur Martin, Robert Benton, Augustin Delago, James K. Min
Journal: Journal of the American College of Cardiology (2008)
Judy's Lullaby
Authors: Joyce A. Thomas
Journal: JAMA (2001)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Both Stat3-Activation and Stat3-Independent BCL2 Downregulation Are Important for Interleukin-6–Induced Apoptosis of 1A9-M Cells
Authors: Kenji Oritani, Yoshiaki Tomiyama, Paul W. Kincade, Keisuke Aoyama, Takafumi Yokota, Itaru Matsumura, Yuzuru Kanakura, Koichi Nakajima, Toshio Hirano, Yuji Matsuzawa
Journal: Blood (1999)
Pegylated Interferon-α2a and Ribavirin versus Pegylated Interferon-α2b and Ribavirin in Chronic Hepatitis C
Authors: Nicolas Flori, Natalie Funakoshi, Yohan Duny, Jean-Christophe Valats, Michael Bismuth, Dimitri Christophorou, Jean-Pierre Daurès, Pierre Blanc
Journal: Drugs (2013)
Abstract 14972: Chamber-specific Downregulation of β1 and Dopamine Receptors in Maladaptive Models of Right Ventricular Hypertrophy and Right Heart Failure
Authors: Kishan S Parikh, Lin Piao, Yong-Hu Fang, Peter T Toth, Stephen L Archer
Journal: Circulation (2011)

Introduction: The autonomic nervous system is activated in patients with right ventricular hypertrophy (RVH) related to pulmonary hypertension. We have preliminary evidence that dopamine is inferio...
Determinants Of Demethylation and Clinical Response In AML Patients Treated With SGI-110, a Novel Subcutaneous (SQ) Hypomethylating Agent (HMA) In a Phase 1 Study
Authors: Woonbok Chung, Pietro Taverna, John F Lyons, Yong Hao, Mohammad Azab, Hagop M. Kantarjian, Patricia Kropf, Jean-Pierre Issa
Journal: Blood (2013)
YY1 imprint status and role in ovarian carcinogenesis
Authors: Zhiqing Huang, Alison H. Gusberg, Regina S. Whitaker, Andrew Berchuck, Susan K. Murphy
Journal: Cancer Research (2006)

1572  Purpose. YIN-YANG 1 (YY1) encodes a zinc finger protein that exhibits diverse effects on cell function through its ability to both positively and negatively influence transcription of many other genes. YY1 is located ∼0.5 Mb centromeric to the imprinted cluster on human 14q32.2 but its imprint status has not been determined in humans. Our previous microarray analysis of advanced stage serous epithelial ovarian cancers indicated that YY1 is one of the most differentially expressed genes between short term (less then 3y) and long term (more than 7y) survivors, with elevated YY1 expression in the long term survivors (p = 0.00003; Clin. Cancer Res. 2005, 11:3686-3696). The purpose of this study was to determine whether YY1 is subject to genomic imprinting, whether it is deregulated by hypermethylation in epithelial ovarian cancers, and the potential role of YY1 in ovarian cancer cell growth. Procedures. Allelic expression of YY1 was determined by nucleotide sequencing of cDNA from heterozygous individuals. The methylation status of the YY1 promoter was analyzed using MS-PCR and bisulfite sequencing. Transient transfection of siRNA oligos was performed in quadruplicate to suppress YY1 expression in ovarian cell lines and was verified using quantitative real time RT-PCR. The effect of YY1 knockdown was measured using assays for cell proliferation and anchorage-independent growth. Results. Of 12 heterozygous tumor specimens, 11 exhibited biallelic expression of YY1 cDNA. YY1 was also expressed from both parental alleles in a panel of eight human fetal tissues. The YY1 promoter CpG island was unmethylated in 24 normal lymphocyte samples and 87 ovarian tumors, including 24 short term and 21 long term survivors. siRNA-mediated suppression of YY1 resulted in a 13% and 29% reduction in cell proliferation in the ovarian cancer cell lines, HEY (p = 0.02) and HEYA8 (p = 0.006), respectively, as compared to controls which received a non-silencing siRNA oligo. We also observed a substantial inhibition in anchorage independent growth, with HEY and HEYA8 cell lines exhibiting a 72% and 88% reduction in colony number, respectively. Conclusions. Our results indicate that YY1 is not imprinted in humans. Monoallelic YY1 expression observed in one cancer specimen may reflect loss of heterozygosity, since this region of 14q is a known target of LOH in ovarian cancers. Decreased YY1 expression in short term survivors is not due to promoter hypermethylation. The outcome of siRNA-mediated knockdown of YY1 in ovarian cancer cell lines suggests that YY1 is contributing to their oncogenic phenotype. Together, our results show that YY1 has an important role in ovarian carcinogenesis but further work will be required to delineate its apparently divergent functions in vitro and in vivo.