EXFOLIATIVE DERMATITIS FOLLOWING PENICILLIN THERAPY
Authors: D. E. Nolan, George W. Pedigo
Journal: Annals of Internal Medicine (1946)

Case Reports1 October 1946EXFOLIATIVE DERMATITIS FOLLOWING PENICILLIN THERAPYD. E. NOLAN, GEORGE W. PEDIGO JR.D. E. NOLANSearch for more papers by this author, GEORGE W. PEDIGO JR.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-25-4-725 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptOn reviewing the literature we have found no reports of exfoliative dermatitis due to penicillin therapy, hence this report.Reactions to penicillin, however, are not infrequent and are generally not serious. Kolodny and Denhoff1in their study of 124 young men receiving penicillin therapy divided their reactions into the "immediate," those appearing within 24 hours, and the "delayed" which usually occur between seven and 14 days after the initiation of treatment. They report an incidence of 16 per cent "immediate" reactions, characterized by generalized rash, edema, gastrointestinal symptoms and "id" reactions. Seven per cent of all patients developed "delayed" reactions...Bibliography1. KOLODNYDENHOFF MWE: Reactions in penicillin therapy, Jr. Am. Med. Assoc., 1946, cxxx, 1058-1061. CrossrefGoogle Scholar2. FLINNMCGEEFEATHERTONKERN LBLCWPDO: Skin lesions attending the use of penicillin, Delaware State Med. Jr., 1945, xvii, 133. Google Scholar3. LYONS C: Penicillin therapy of surgical infections in the U. S. Army, Jr. Am. Med. Assoc., 1945, cxxiii, 1007. Google Scholar4. PYLERATTNER HDH: Contact dermatitis from penicillin, Jr. Am. Med. Assoc., 1944, cxxv, 903. CrossrefGoogle Scholar5. BINKLEYBROCKMOLE GWA: Dermatitis from penicillin, Arch. Dermat. and Syph., 1944, l, 326. CrossrefGoogle Scholar6. BARKER AN: Allergic reactions to penicillin, Lancet, 1945, i, 177. CrossrefGoogle Scholar7. GRAVESCARPENTERUNANGST WNCCRW: Recurrent vesicular eruptions appearing during administration of penicillin, Arch. Dermat. and Syph., 1944, l, 6. CrossrefGoogle Scholar8. SULLENS WE: Simulating serum sickness reaction to penicillin, U. S. Naval Med. Bull., 1945, xlv, 752. Google Scholar9. PRICE IC: Severe allergic reactions to intramuscular penicillin, Canad. Med. Assoc. Jr., 1945, liii, 485. Google Scholar10. CORMINAJACOBSENSMITH FELYEL: Reactions to penicillin, Bull. U. S. Army Med. Dept., 1945, lv, 694. Google Scholar11. CRIEP LH: Allergy to penicillin, Jr. Am. Med. Assoc., 1944, cxxvi, 429. CrossrefGoogle Scholar12. PRICEMCNAIRYWHITE DEDJEL: Severe asthma; delayed sensitization to penicillin, Jr. Am. Med. Assoc., 1945, cxxviii, 183. CrossrefGoogle Scholar13. HAILEYMILLARD HEEB: Foreign protein reaction from penicillin, U. S. Nav. Med. Bull., 1945, xliv, 207. Google Scholar14. CRISP LH: Allery, Jr. Am. Med. Assoc., 1944, cxxvi, 429. Google Scholar15. MORRISDOWNING GEJG: Bullous dermatitis, Jr. Am. Med. Assoc., 1945, cxxvii, 711. CrossrefGoogle Scholar16. MEADSHARRISFINLAND MHWM: Treatment of pneumococcic pneumonia with penicillin, New England Jr. Med., 1945, ccxxxii, 747-755. CrossrefGoogle Scholar17. WELCHROSTENBERG HA: Hypersensitivity of the tuberculin type to crystalline penicillin sodium, Jr. Am. Med. Assoc., 1944, cxxvi, 10. CrossrefGoogle Scholar18. CHOWMCKEE BFCM: Interaction between crystalline penicillin and human plasma proteins, Science, 1945, ci, 67. CrossrefGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: *Received for publication April 30, 1946.From the Medical Service, Veterans Administration Center, Dayton, Ohio.Published with the permission of the Chief Medical Director of the Veterans Administration who assumes no responsibility for the opinions expressed or conclusions drawn by the authors. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byComplications of antibiotic therapySyphilis 1 October 1946Volume 25, Issue 4Page: 725-728KeywordsEdemaMedical servicesPenicillinRashes Issue Published: 1 October 1946 PDF downloadLoading ...