tbuckley/cabot-search huggingface dataset:
Clinicopathologic Analysis of Multiple (Five or More) Atypical Adenomatous Hyperplasias (AAHs) of the Lung: Evidence for the AAH-Adenocarcinoma Sequence
Authors: Akiko Miyagi Maeshima, Naobumi Tochigi, Akihiko Yoshida, Hisao Asamura, Koji Tsuta, Hitoshi Tsuda
Journal: Journal of Thoracic Oncology (2010)
Managing gynaecological emergencies with laparoscopy.
Authors: A. L. Magos, R. Baumann, A. C. Turnbull
Journal: BMJ (1989)

A consecutive series of 49 women (50 procedures), whose conditions were haemodynamically stable, presenting with acute lower abdominal pain, pelvic tenderness, and either a urine concentration of greater than 50 U/l beta human chorionic gonadotrophin or a pelvic mass shown by ultrasonography were treated with operative laparoscopy under video monitoring (videopelviscopy) as an alternative to laparotomy. Ectopic pregnancy, ovarian and non-ovarian cysts, pelvic adhesions, endometriosis, and fibroids were found, for which salpingotomy, salpingectomy and salpingo-oophorectomy, cystectomy, adhesiolysis, thermocoagulation, and myomectomy were carried out by laparoscopy. In one patient pelviscopy was repeated because of persistent tubal pregnancy after the fimbria was expressed. Laparotomies were carried out on three patients because treatment was not possible by laparoscopy and on a further patient two days after adhesiolysis had been attempted. These were the only serious complications. For the 46 cases (45 patients) in which operative laparoscopy was successful the mean stay in hospital was 1.9 days after operation, and this group of patients returned to normal activities and to work after an average of 2.3 and 2.6 weeks respectively. Most gynaecological emergencies that are managed by laparotomy can be treated by laparoscopy and benefit both patients and the health service.
A CASE OF DERMATITIS FROM 9-BROMO-FLUORENE AND A PECULIAR REACTION TO A PATCH-TEST.
Authors: Alfred Cavendish
Journal: British Journal of Dermatology (1940)

Journal Article A CASE OF DERMATITIS FROM 9‐BROMO‐FLUORENE AND A PECULIAR REACTION TO A PATCH‐TEST. Get access Alfred Cavendish, M.B., B.S.Lond. Alfred Cavendish, M.B., B.S.Lond. Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology and Syphilis, Volume 52, Issue 5, 1 May 1940, Pages 155–164, https://doi.org/10.1111/j.1365-2133.1940.tb10860.x Published: 01 May 1940
Effects of Raloxifene on Serum Lipids and Coagulation Factors in Healthy Postmenopausal Women
Authors: Brian W. Walsh
Journal: JAMA (1998)

Context.-Raloxifene is a selective estrogen receptor modulator that has estrogen-agonistic effects on bone and estrogen-antagonistic effects on breast and uterus.Objective.-Toidentify the effects of raloxifene on markers of cardiovascular risk in postmenopausal women, and to compare them with those induced by hormone replacement therapy (HRT).Design.-Double-blind, randomized, parallel trial.Setting.-Eight sites in the United States.Participants.-390healthy postmenopausal women recruited by advertisement.Intervention.-Participants were randomized to receive 1 of 4 treatments: raloxifene, 60 mg/d; raloxifene, 120 mg/d; HRT (conjugated equine estrogen, 0.625 mg/d, and medroxyprogesterone acetate, 2.5 mg/d); or placebo.Main Outcome Measures.-Changeand percent change from baseline of lipid levels and coagulation parameters after 3 months and 6 months of treatment.Results.-At the last visit completed, compared with placebo, both dosages of raloxifene significantly lowered low-density lipoprotein cholesterol (LDL-C) by 12% (P Ͻ .001),similar to the 14% reduction with HRT (P Ͻ .001).Both dosages of raloxifene significantly lowered lipoprotein(a) by 7% to 8% (P Ͻ .001),less than the 19% decrease with HRT (P Ͻ .001).Raloxifene increased high-density lipoprotein-2 cholesterol (HDL 2 -C) by 15% to 17% (P Ͻ .05),less than the 33% increase with HRT (P Ͻ .001).Raloxifene did not significantly change high-density lipoprotein cholesterol (HDL-C), triglycerides, or plasminogen activator inhibitor-1 (PAI-1); whereas HRT increased HDL-C by 11% and triglycerides by 20%, and decreased PAI-1 by 29% (for all, P Ͻ .001).Raloxifene significantly lowered fibrinogen by 12% to 14% (P Ͻ .001),unlike HRT, which had no effect.Neither treatment changed fibrinopeptide A or prothrombin fragment 1 and 2.Conclusions.-Raloxifenefavorably alters biochemical markers of cardiovascular risk by decreasing LDL-C, fibrinogen, and lipoprotein(a), and by increasing HDL 2 -C without raising triglycerides.In contrast to HRT, raloxifene had no effect on HDL-C and PAI-1, and a lesser effect on HDL 2 -C and lipoprotein(a).Further clinical trials are necessary to determine whether these favorable biochemical effects are associated with protection against cardiovascular disease.
The anti-IL-17A antibody secukinumab does not attenuate ozone-induced airway neutrophilia in healthy volunteers
Authors: Anne Kirsten, Henrik Watz, Frauke Pedersen, Olaf Holz, Rachel Smith, Gerard Bruin, Stephan Koehne-Voss, Helgo Magnussen, David A. Waltz
Journal: European Respiratory Journal (2012)

The anti-IL-17A antibody secukinumab does not attenuate ozone
Hyperglycemia and Renal Function
Authors: MICHAEL N. GOTTLIEB
Journal: Annals of Internal Medicine (1976)

Comments1 March 1976Hyperglycemia and Renal FunctionMICHAEL N. GOTTLIEB, M.D.MICHAEL N. GOTTLIEB, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-84-3-339_1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: Matas and associates (1) describe the adverse effect of hyperglycemia on renal function. They could not ascribe the change in serum creatinine reported to an artifact in the method of serum creatinine determination and alternatively proposed that there was reversible physiologic injury to the kidney as a consequence of hyperosmolality. I too have seen this phenomenon but have ascribed this to prerenal azotemia as a consequence of dehydration secondary to osmotic diuresis (2). It would be interesting to note the relative changes in the weights of patients of Matas and colleagues with reversion of glucose and creatinine...References1. MATAS A, SIMMONS R, and GOETZ F: Increased serum creatinine resulting from hyperglycemia, mimicking transplant rejection. Ann Intern Med 83:519-520, 1975 LinkGoogle Scholar2. KLEEMAN C and LIBERMAN B: Diabetic acidosis and coma, in Clinical Disorders of Fluid and Electrolyte Metabolism, 2nd ed., edited by MAXWELL MH, KLEEMAN CR. New York, McGraw-Hill, 1972, p. 974 Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: MICHAEL N. GOTTLIEB, M.D.Affiliations: Department of Medicine Peter Bent Brigham Hospital 721 Huntington Avenue Boston, Massachusetts 02115 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 March 1976Volume 84, Issue 3Page: 339-339KeywordsCreatinineGlucoseHyperglycemiaRenal failure ePublished: 1 December 2008 Issue Published: 1 March 1976 PDF downloadLoading ...
Identification of Patients with Cholesterol or Pigment Gallstones by Discriminant Analysis of Radiographic Features
Authors: S. M. Dolgin, J. S. Schwartz, H. Y. Kressel, R. D. Soloway, W. T. Miller, B. W. Trotman, A. S. Soloway, L. I. Good
Journal: New England Journal of Medicine (1981)

In a search for a way to distinguish cholesterol gallstones from pigment gallstones by oral cholecystography, we evaluated 56 patients with surgically confirmed cholelithiasis. Only buoyancy was highly predictive of gallstone composition: all 14 patients with floating stones had cholesterol stones (P less than 0.01), but only one third of the patients with cholesterol stones had stone buoyancy. Using a function derived by stepwise discriminant analysis, we separated patients with cholesterol stones from those with pigment stones. The predictive accuracy was significantly improved: sensitivity was 95 per cent (37 of 39 patients with cholesterol stones), specificity was 82 per cent (14 of 17 patients with pigment stones), and efficiency was 91 per cent (51 of 56 total patients). The resultant function, applied prospectively to 17 additional cases, classified all of them correctly. In patients with cholelithiasis and gallbladders visualized on oral cholecystography, discriminant analysis can improve the prediction of gallstone composition and the subsequent selection of medial or surgical therapy.
The Utility of Cardiac Biomarkers, Tissue Velocity and Strain Imaging, and Cardiac Magnetic Resonance Imaging in Predicting Early Left Ventricular Dysfunction in Patients With Human Epidermal Growth Factor Receptor II–Positive Breast Cancer Treated With Adjuvant Trastuzumab Therapy
Authors: Nazanin Fallah-Rad, Jonathan R. Walker, Anthony Wassef, Matthew Lytwyn, Sheena Bohonis, Tielan Fang, Ganhong Tian, Iain D.C. Kirkpatrick, Pawan K. Singal, Marianne Krahn, Debjani Grenier, Davinder S. Jassal
Journal: Journal of the American College of Cardiology (2011)
Murine mucopolysaccharidosis type VII: long term therapeutic effects of enzyme replacement and enzyme replacement followed by bone marrow transplantation.
Authors: M S Sands, C Vogler, A Torrey, B Levy, B Gwynn, J Grubb, W S Sly, E H Birkenmeier
Journal: Journal of Clinical Investigation (1997)

We demonstrated previously that short term administration of recombinant beta-glucuronidase to newborn mice with mucopolysaccharidosis type VII reduced lysosomal storage in many tissues. Lysosomal storage accumulated gradually after cessation of enzyme replacement therapy. Mice alive at 1 yr of age had decreased bone deformities and less lysosomal storage in cortical neurons. Here we compare the effects of long term enzyme replacement initiated either at birth or at 6 wk of age, and of enzyme administration initiated at birth followed by syngeneic bone marrow transplantation (BMT) at 5 wk of age. Several mice from each treatment group lived to at least 1 yr of age. Liver and spleen samples had beta-glucuronidase levels ranging from 2.4 to 19.8% of normal and showed a parallel decrease in lysosomal storage. The combination of enzyme replacement therapy followed by BMT reduced lysosomal distension in meninges, corneal fibroblasts, and bone when compared with treatment with enzyme alone. Mice treated at birth had less lysosomal storage in some neurons of the brain and the skeletal dysplasia was less severe when compared to mice whose treatment was delayed until 6 wk of age. We conclude that both enzyme replacement alone and early enzyme replacement followed by BMT have long term positive effects on murine mucopolysaccharidosis type VII. In addition, treatment started at birth is far more effective than treatment initiated in young adults.
NICE gives go ahead to intrabeam radiotherapy for breast cancer
Authors: H. Mooney
Journal: BMJ (2014)

Intrabeam radiotherapy, a single dose treatment used during surgery for patients with breast cancer, has been given the go ahead for use in the NHS in England.

The National Institute for Health and Care Excellence (NICE) has issued draft guidance stating that the treatment should be considered for people with early stage breast cancer.1 Intrabeam radiotherapy can be given as a single dose radiotherapy during breast cancer surgery and would eliminate the need for patients to make additional trips to hospital for treatment.

Carole Longson, NICE’s director of health …
Potential Preventability of First Attacks of Acute Rheumatic Fever in Children
Authors: Burton J. Grossman, Jeremiah Stamler
Journal: JAMA (1963)

The authors studied 110 consecutive cases of children hospitalized for a first attack of rheumatic fever. In each case a judgment was made as to the adequacy of the preceding treatment in the light of recommendations made by the American Heart Association. In 94 of the 110 cases there had been an infection within 5 weeks before the onset of rheumatic fever. The patient had been seen by a physician in 62 cases, throat cultures had been made in 17, and antibiotics had been given in 50. In only 10 patients was the preceding therapy deemed adequate. Residual cardiac involvement was noted in 54 of the 110 at the time of discharge from the hospital. It was estimated that about 84% of these cases of rheumatic fever had been preventable.
Pharmacological aspects of anticancer drug-induced emesis with emphasis on serotonin release and vagal nerve activity
Authors: Masaru Minami, Toru Endo, Masahiko Hirafuji, Naoya Hamaue, Yanxia Liu, Tsutomu Hiroshige, Masahiro Nemoto, Hideya Saito, Mitsuhiro Yoshioka
Journal: Pharmacology & Therapeutics (2003)
Complement binding by two developmental stages of Leishmania major promastigotes varying in expression of a surface lipophosphoglycan.
Authors: S M Puentes, D L Sacks, R P da Silva, K A Joiner
Journal: The Journal of Experimental Medicine (1988)

The binding of complement by two developmentally distinct stages of Leishmania major has been studied. Noninfective log phase growth (LOG) promastigotes (serum sensitive) activate complement with deposition of covalently bound C3b onto the surface of the parasite. Infective, peanut agglutinin (PNA-) metacyclic stage promastigotes (serum resistant) also bear mainly C3b after incubation in serum, but a major portion of deposited C3 is present as a 110 X 10(3) mol wt C3 fragment. Whereas deposition of C3b on LOG promastigotes is mediated through the alternative pathway. PNA- parasites are unable to activate the alternative pathway in nonimmune serum. C3 is released from the parasite surface by proteolytic cleavage, at a rate which is nearly threefold greater for LOG than for PNA- promastigotes. Immunoprecipitation experiments show that the developmentally regulated lipophosphoglycan is a major C3 acceptor on both LOG and PNA- parasites. These experiments, which are the first to compare the form and processing of complement on infective and noninfective promastigotes of Leishmania, provide a framework for further definition of the differential C3 receptor-dependent uptake and survival of these parasites within mononuclear phagocytes.
Maternal vaginal microflora during pregnancy and the risk of asthma hospitalization and use of antiasthma medication in early childhood
Authors: Christine Stabell Benn, Poul Thorsen, Jørgen Skov Jensen, Birgitte Boysen Kjær, Hans Bisgaard, Morten Andersen, Klaus Rostgaard, Bengt Björkstén, Mads Melbye
Journal: Journal of Allergy and Clinical Immunology (2002)
3p22.1 and 10q22.3 Deletions Detected by Fluorescence In Situ Hybridization (FISH): A Potential New Tool for Early Detection of Non-small Cell Lung Cancer (NSCLC)
Authors: Sai Yendamuri, Ara A. Vaporciyan, Tanweer Zaidi, Lei Feng, Ricardo Fernandez, Nebiyou B. Bekele, Wayne L. Hofstetter, Feng Jiang, Reza J. Mehran, David C. Rice, Margaret R. Spitz, Stephen G. Swisher, Garrett L. Walsh, Jack A. Roth, Ruth L. Katz
Journal: Journal of Thoracic Oncology (2008)
A CASE OF CONGENITAL SYPHILIS COMPLICATED BY A MIXED INFECTION WITH THE STAPHYLOCOCCUS AND STREPTOCOCCUS PYOGENES.
Authors: H. GIDEON WELLS
Journal: JAMA (1897)

On April 29, the body of a child was brought to the laboratory of Rush Medical College for examination. The autopsy was performed immediately, before postmortem changes could have possibly occurred. The child was born in the practice of Dr. A. B. Strong, who furnishes the following history: The mother was 20 years of age, a primipara, with a good personal and family history. She had been married one year. The labor was an uneventful one, a vertex presentation. The child was alive when born, but died after gasping a few times. The father was 23 years old and denied any specific history, as did the mother, and presented no suspicious scars. Dr. Strong, his interest in the case having been aroused by the condition of the child, conducted a careful investigation into the history of the parents, but was unable to obtain the slightest evidence of a primary specific
Utility of endoscopic ultrasound and fine needle aspiration in the diagnosis of pancreatic neuroendocrine tumours
Authors: J. S. Leeds, M. M. Nayar, V. Wadehra, K. E. Oppong
Journal: Gut (2011)

<h3>Introduction</h3> Endoscopic ultrasound (EUS) is used to stage and sample lesions throughout the gastrointestinal tract and is very helpful in assessing pancreatic masses. Neuroendocrine tumours (NETs) of the pancreas account for 1–2% of mass lesions but require differentiation from carcinomas as the management and prognosis are different. We aimed to assess the utility of EUS and fine needle aspiration cytology (FNA) in the diagnosis of NETs in our unit. <h3>Methods</h3> Patients are prospectively added to the EUS FNA database when attending for EUS and the period April 2003–April 2010 was examined. All resected lesions were examined for EUS and FNA findings and patient age and gender, lesion site, EUS characteristics and FNA findings were recorded. Sensitivity, specificity, positive and negative predictive value and accuracy were calculated. <h3>Results</h3> 829 EUS FNA procedures (793 patients) were for a solid lesion of which 237 had definitive histology. 34 (4.3%) patients (mean age 59.7years, 19 males) had a NET with the majority (31/34) being found in the head of the pancreas. All lesions were amenable to FNA but 10/34 lesions yielded inadequate material for cytological analysis (all of which were prior to in room cytological support). The number of passes in adequate samples was higher than in inadequate samples (median 3 vs 2, p=0.058). The sensitivity, specificity, positive, predictive value, negative predictive value and accuracy of EUS and FNA for detecting pancreatic NETs were 0.71, 0.99, 0.77, 0.99 and 0.95 respectively. <h3>Conclusion</h3> EUS and FNA is a helpful modality for assessing and sampling potential pancreatic NETs with a positive sample correlating highly with histology. The low sensitivity in the present study may be related to inadequate samples which could be improved by increasing the number of passes into the lesion and in room cytological support.
A mouse model for cystic biliary dysgenesis in autosomal recessive polycystic kidney disease (ARPKD)
Authors: Markus Moser, Sonja Matthiesen, Jutta Kirfel, Hubert Schorle, Carsten Bergmann, Jan Senderek, Sabine Rudnik‐Schöneborn, Klaus Zerres, Reinhard Buettner
Journal: Hepatology (2005)

Autosomal recessive polycystic kidney disease (ARPKD) is an important cause of liver- and renal-related morbidity and mortality in childhood. Recently, PKHD1, the gene encoding the transmembrane protein polyductin, was shown to be mutated in ARPKD patients. We here describe the first mouse strain, generated by targeted mutation of Pkhd1. Due to exon skipping, Pkhd1ex40 mice express a modified Pkhd1 transcript and develop severe malformations of intrahepatic bile ducts. Cholangiocytes maintain a proliferative phenotype and continuously synthesize TGF-β1. Subsequently, mesenchymal cells within the hepatic portal tracts continue to synthesize collagen, resulting in progressive portal fibrosis and portal hypertension. Fibrosis did not involve the hepatic lobules, and we did not observe any pathological changes in morphology or function of hepatocytes. Surprisingly and in contrast to human ARPKD individuals, Pkhd1ex40 mice develop morphologically and functionally normal kidneys. In conclusion,our data indicate that subsequent to formation of the embryonic ductal plate, dysgenesis of terminally differentiated bile ducts occurs in response to the Pkhd1ex40 mutation. The role of polyductin in liver and kidney may be functionally divergent, because protein domains essential for bile duct development do not affect nephrogenesis in our mouse model. Supplementary material for this article can be found on the HEPATOLOGY website (http://www.interscience.wiley.com/jpages/0270-9139/suppmat/index.html). (HEPATOLOGY 2005.)
Granulomatous arthritis in Crohn's disease
Authors: C. Lindstrom, H. Wramsby, G. Ostberg
Journal: Gut (1972)

A case is described of non-necrotizing, epithelioid cell granulomatous synovitis of the ankle of a 22-year-old man with Crohn9s disease. It appears to be the first published example of granulomatous arthritis in association with Crohn9s disease.
Effectiveness of Bystander CPR
Authors: Max Harry Weil, Wanchun Tang, Gad Amith, Marko Noc
Journal: JAMA (1996)

<h3>To the Editor.</h3> —We applaud the effort by Dr Gallagher and colleagues<sup>1</sup>to extend their earlier study on the disappointing outcomes of out-of-hospital cardiac arrest in New York City<sup>2</sup>to evaluate the effectiveness of bystander-initiated cardiopulmonary resuscitation (CPR) in that large urban setting. We also acknowledge that outcome is likely to be contingent on the effectiveness with which precordial compression is performed, although there is evidence that rescue breathing is of much less importance in their patient subset of sudden (nonasphyxial) deaths.<sup>3-6</sup> The authors evaluated the capability of emergency medical technicians to make objective judgments on the effectiveness of the interventions rendered by bystanders. Their evaluation was based on CPR trials on mannequins. Yet, this did not serve as a control on post hoc observer bias. The medical rescue personnel were both observers and providers. They provided professional life support and were witnesses to the outcome of
Experts predict big rise in dengue fever in South East Asia
Authors: J. Parry
Journal: BMJ (2003)

Countries in South East Asia, where dengue fever is endemic, are bracing themselves for an expected sharp rise in cases next year, experts at the World Health Organization have reported.

Not enough effort is going into vector control (the main vector being the mosquito), because most donor organisations are putting their money into the development of a vaccine, the experts say.

The disease is also spreading beyond its traditional boundaries. More than 450 cases were reported this year in Cairns and Townsville, Australia, the biggest outbreak the region has seen. Hong Kong had its first major outbreak last year, with 44 cases. And in 2001 there were 1394 cases in neighbouring Macau, which has only ever had one case before, in 1996.

Because infected humans can transmit dengue to susceptible mosquitoes, population movement is bringing the …
Uvular Angioedema (Quincke's Disease)
Authors: Andrew Kestler, Linda Keyes
Journal: New England Journal of Medicine (2003)

A 19-year-old man without a history of asthma or allergies presented to the emergency department with difficulty in breathing. He had snorted and smoked cocaine three hours before presentation, after which tightness of the throat developed, along with throat pain and difficulty in swallowing. On examination, the patient was drooling and spoke with a muffled voice. On admission, his vital signs revealed mild tachycardia and tachypnea, without hypoxemia on pulse oximetry. His uvula was markedly edematous (2 cm in diameter) without erythema. There was no stridor or wheeze. The symptoms improved over a period of five hours after treatment with . . .