tbuckley/cabot-search huggingface dataset:
2008 Outbreak of Salmonella Saintpaul Infections Associated with Raw Produce
Authors: Casey Barton Behravesh, Rajal K. Mody, Jessica Jungk, Linda Gaul, John T. Redd, Sanny Chen, Shaun Cosgrove, Erin Hedican, David Sweat, Lina Chávez-Hauser, Sandra L. Snow, Heather Hanson, Thai-An Nguyen, Samir V. Sodha, Amy L. Boore, Elizabeth Russo, Matthew Mikoleit, Lisa Theobald, Peter Gerner-Smidt, Robert M. Hoekstra, Frederick J. Angulo, David L. Swerdlow, Robert V. Tauxe, Patricia M. Griffin, Ian T. Williams
Journal: New England Journal of Medicine (2011)

Raw produce is an increasingly recognized vehicle for salmonellosis. We investigated a nationwide outbreak that occurred in the United States in 2008.We defined a case as diarrhea in a person with laboratory-confirmed infection with the outbreak strain of Salmonella enterica serotype Saintpaul. Epidemiologic, traceback, and environmental studies were conducted.Among the 1500 case subjects, 21% were hospitalized, and 2 died. In three case-control studies of cases not linked to restaurant clusters, illness was significantly associated with eating raw tomatoes (matched odds ratio, 5.6; 95% confidence interval [CI], 1.6 to 30.3); eating at a Mexican-style restaurant (matched odds ratio, 4.6; 95% CI, 2.1 to ∞) and eating pico de gallo salsa (matched odds ratio, 4.0; 95% CI, 1.5 to 17.8), corn tortillas (matched odds ratio, 2.3; 95% CI, 1.2 to 5.0), or salsa (matched odds ratio, 2.1; 95% CI, 1.1 to 3.9); and having a raw jalapeño pepper in the household (matched odds ratio, 2.9; 95% CI, 1.2 to 7.6). In nine analyses of clusters associated with restaurants or events, jalapeño peppers were implicated in all three clusters with implicated ingredients, and jalapeño or serrano peppers were an ingredient in an implicated item in the other three clusters. Raw tomatoes were an ingredient in an implicated item in three clusters. The outbreak strain was identified in jalapeño peppers collected in Texas and in agricultural water and serrano peppers on a Mexican farm. Tomato tracebacks did not converge on a source.Although an epidemiologic association with raw tomatoes was identified early in this investigation, subsequent epidemiologic and microbiologic evidence implicated jalapeño and serrano peppers. This outbreak highlights the importance of preventing raw-produce contamination.
Transcriptional Modification by a CASK-Interacting Nucleosome Assembly Protein
Authors: Guey-Shin Wang, Chen-Jei Hong, Tsen-Yann Yen, Hsin-Yi Huang, Yvonne Ou, Tzyy-Nan Huang, Wei-Gang Jung, Ting-Yu Kuo, Morgan Sheng, Ting-Fang Wang, Yi-Ping Hsueh
Journal: Neuron (2004)
Renal Cell Carcinoma and Erythropoietin
Authors: Cem Sungur
Journal: Annals of Internal Medicine (1995)

Letters1 November 1995Renal Cell Carcinoma and ErythropoietinCem Sungur, MDCem Sungur, MDBayindir Medical Center; Ankara, TurkeySearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-123-9-199511010-00022 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:I read the interesting report by Rubins [1] about his patient with metastatic renal cell carcinoma who responded to human recombinant erythropoietin. The underlying mechanisms of the association between renal cell carcinoma and erythropoietin are still unknown. I describe a patient who developed a local recurrence of renal cell carcinoma while receiving human recombinant erythropoietin.A 51-year-old man had left radical nephrectomy for renal cell carcinoma. The disease recurred 2 years later in his right kidney, and a partial nephrectomy was done. The patient was admitted to a hemodialysis unit, where he received dialysis three times per ...References1. Rubins J. Metastatic renal cell carcinoma: response to treatment with human recombinant erythropoietin. Ann Intern Med. 1995; 122:676-7. Google Scholar Author, Article, and Disclosure InformationAuthors: Cem Sungur, MDAffiliations: Bayindir Medical Center; Ankara, Turkey PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byFunctional significance of erythropoietin in renal cell carcinomaErythropoietin is a JAK2 and ERK1/2 effector that can promote renal tumor cell proliferation under hypoxic conditionsImmuntherapie des metastasierten Nierenzellkarzinoms mit Interleukin-2, Interferon-α2a und Erythropoetin-β 1 November 1995Volume 123, Issue 9Page: 732-733KeywordsAdrenal glandsAdrenalectomyBehaviorErythropoietinImmunosuppressivesMedical dialysisNephrectomyRenal cell carcinomaRenal diseasesRenal failure ePublished: 15 August 2000 Issue Published: 1 November 1995 Copyright & PermissionsCopyright © 1995 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Comparison of the Hemodynamic Effects of Mercurial Diuretics and Digitalis in Congestive Heart Failure
Authors: BERTHA RADER, WARREN W. SMITH, ADOLPH R. BERGER, LUDWIG W. EICHNA
Journal: Circulation (1964)

The non-xanthine-containing mercurial diuretic mercaptomerin (Thiomerin), a noncardiotonic agent, was given repeatedly to 14 patients with congestive heart failure until all edema fluid had been eliminated. There resulted relief of subjective symptoms and removal of the characteristic physical signs of circulatory congestion to the point where subjects were considered in "cardiac compensation"; reduction of the elevated intracardiac pressures, in the right atrium, right ventricle, and pulmonary artery; variable changes in cardiac function (cardiac output) and cardiocirculatory (arterial-mixed venous oxygen difference) function, with improvement toward normal in half of the patients and no change in the other half. In subjects in whom full mercurial diuresis alone improved the cardiac and cardiocirculatory functions, subsequent digitalization produced no further improvement in these functions. These patients were in a first or second episode of cardiac decompensation. In subjects in whom full diuresis alone did not alter the cardiac and cardiocirculatory dynamics, subsequent digitalization produced an increase in cardiac output and a decrease in A-V oxygen difference toward normal values. These subjects usually had had one or several previous episodes of congestive failure. When there was persistent chronic congestive heart failure, neither mercurial diuretic nor digitalis therapy altered the low cardiac output or the high A-V oxygen difference. Removal of the edema and vascular congestion by diuresis alone nevertheless produced subjective improvement. In those patients in whom an increase in cardiac output occurred as the mercurial diuretic eliminated edema and lowered the elevated intracardiac pressures, the response may be considered consistent with Starling's law of the heart in man in congestive heart failure. The data clearly make the point that it is the circulatory congestion that produces the symptoms and the physical signs traditionally considered characteristic of congestive heart failure. Removal of the circulatory congestion, however accomplished, relieves the symptoms and physical signs of congestive heart failure, regardless of whether or not cardiac function is improved toward the normal. Circulatory congestion does not necessarily indicate, nor correlate with, the status of cardiac function.
A Novel Protein, Densin, Expressed by Glomerular Podocytes
Authors: Heikki Ahola, Eija Heikkila[Combining Diaeresis], Eva A[Combining Ring Above]stro[Combining Diaeresis]m, Masaki Inagaki, Ichiro Izawa, Hermann Pavensta[Combining Diaeresis]dt, Dontscho Kerjaschki, Harry Holtho[Combining Diaeresis]fer
Journal: Journal of the American Society of Nephrology (2003)

With the recent molecular findings, the podocyte is emerging as a key cell type involved in glomerular damage, but protein complexes involved remain poorly understood. To systematically search for additional podocyte molecules interacting with nephrin, a key structural molecule of the interpodocyte filtration slit, precipitation of glomerular lysates was set out with anti-nephrin antibodies to identify members of the nephrin-associated protein complex. Proteins of the precipitate were subsequently identified with MALDI-TOF mass analysis. One of the proteins thus obtained showed identity with densin, a protein originally purified from rat forebrain postsynaptic density fraction and so far shown to be highly brain-specific. The expression of densin appeared distinctly in the glomerulus and cultured podocytes by RT-PCR. Immunoblotting studies revealed a specific band of 185 kD in brain and cultured podocytes; in human glomerulus, densin appeared as a 210-kD band. By immunocytochemistry, densin localizes in glomeruli in a podocyte-like pattern. Electron microscopic studies revealed densin localization in the slit diaphragm area. Due to its known involvement in the synaptic organization, maintenance of cell shape and polarity in nerve cells, together with its demonstrated interactions with α-actinin-4, densin may share the same functions in podocytes by associating with the nephrin interacting protein complex at the slit diaphragm. E-mail: harry.holthofer@helsinki.fi Received August 21, 2002. Accepted April 13, 2003.
HYPOXIA-INDUCIBLE FACTOR 1-ALPHA REGULATES ATHEROSCLEROSIS VIA MACROPHAGE ACTIVATION AND METABOLIC PATHWAYS
Authors: Parmanand Singh, Ahmed Tawakol, Esad Vucic, Hamed Emami, Zahi Fayad, Jagat Narula, James Rudd, Alex Morss, Jeffrey Swanson, Sara Fontanez, Paqui Traves, Alberto Tejedor, Maria Pimentel-Santillana, Marina Mojena, Mara Fernndez-Velasco, Lisardo Bosca
Journal: Journal of the American College of Cardiology (2014)
Expression of prostaglandin E2 receptor subtypes on cells in sputum from patients with asthma and controls: Effect of allergen inhalational challenge
Authors: Sun Ying, Brian J. O'Connor, Qiu Meng, Natalie Woodman, Steven Greenaway, Helen Wong, Kirsty Mallett, Tak H. Lee, Chris Corrigan
Journal: Journal of Allergy and Clinical Immunology (2004)
Tumorlets in Familial History of Bronchopulmonary Carcinoid
Authors: Ugo De Giorgi, Francesca Fanini, Dino Amadori, Alessandra Cancellieri, Giammaria Fiorentini, Venerino Poletti, Luisa Barzon, Giulia Masi
Journal: Journal of Thoracic Oncology (2011)
Abstract 2867: A novel WT1-derived peptide induces cellular senescence and inhibits tumor growth in a human melanoma cell line and xenograft model
Authors: Mariana Hiromi Massaoka, Alisson Leonardo Matsuo, Felipe Valença Pereira, Carlos Rogerio Figueiredo, Jorge Augusto Scutti, Natália Girola, Luiz Rodolpho Travassos
Journal: Cancer Research (2012)

Abstract Malignant melanoma is the most aggressive and deadly type of skin cancer. The Wilms tumor protein 1 (WT1) is a transcription factor that has been associated with melanoma oncogenesis and proliferation, hence could be a target of tumor control procedures. A lysine-arginine rich peptide (WT1 pTj) based on WT1 C-terminal zinc finger domain was synthesized and tested for anti-proliferative effects on human and murine melanoma cell lines (A2058 and B16F10-Nex2, respectively), including inhibition of cell growth and colony formation, cell cycle arrest and induction of cell senescence. Internalization of WT1 pTj into A2058 cells was established by confocal microscopy, using biotinylated peptide and staining by streptoavidin-FITC. An effect on p53 activity was measured by a luciferase reporter assay. Competitive ELISA assay was performed to verify whether the peptide interferes with p53-WT1 interaction. In vivo, athymic nude mice and C57Bl/6 were inoculated with A2058 and B16F10-Nex2 cells, respectively, and treated for 5 consecutive days with C-amidated WT1 pTj. Here, we show that WT1 pTj decreased, in a dose and time dependent manner, the number of melanoma viable cells. The anti-proliferative activity of WT1 pTj was linked to an irreversible G1 cell cycle arrest and induction of senescence as suggested by positive staining for beta-galactosidase. Treatment with WT1 pTj reduced the total number of soft-agar colonies by A2058 melanoma cells. The peptide entered the cell within 15 minutes and was diffusely distributed throughout the cell, including the nucleus. Moreover, WT1 pTj enhanced p53 activity and competed with WT1 protein for binding to p53. In vivo, WT1 pTj reduced the number of lung nodules in the B16F10-Nex2 syngeneic model of metastatic melanoma and prolonged survival of mice in the A2058 subcutaneous xenograft model. In conclusion, WT1 pTj peptide entered cancer cells and promoted antitumor activity in vitro and in vivo. The data support the hypothesis that WT1 pTj may prevent important interactions between WT1 protein and its partners via a zinc finger motif, inhibiting melanoma development. Therefore, WT1 pTj is a promising agent against WT1-expressing malignancies (e.g. MCF-7 but not SK-BR-3 breast cancer or normal human fibroblasts; and also HL60 acute myeloid leukemia). WT1 pTj may act also as a trojan carrier peptide for potential drug delivery. Supported by FAPESP grant 2010/51423-0 and the Brazilian National Research Council (CNPq) Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 103rd Annual Meeting of the American Association for Cancer Research; 2012 Mar 31-Apr 4; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2012;72(8 Suppl):Abstract nr 2867. doi:1538-7445.AM2012-2867
TCT-374 Morphological Characteristics Of Coronary Artery Spasm Sites In Vasospastic Angina: An Optical Coherence Tomography Study
Authors: Eun-Seok Shin, Soe Hee Ann, Gillian K. Balbir Singh, Kyung Hun Lim, Hyuck-Jun Yoon, Seung-Ho Hur, Ae-Young Her, Bon-Kwon Koo, Takashi Akasaka
Journal: Journal of the American College of Cardiology (2014)
Artificial Pacemakers
Authors: KINSMAN E. WRIGHT, HENRY D. MCINTOSH
Journal: Circulation (1973)

The development of artificial pacemakers for the electrical control of the cardiac rhythm has greatly enhanced the physician's ability to treat cardiac dysrhythmias. Pacemakers have been useful in treating Stokes-Adams syndrome and symptomatic bradyeardias; they have helped control the occurrence of tachyarrhythmias and have played an important role in the management of arrhythmias accompanying myocardial infarctions. With their more frequent use, pacemakers have contributed to our knowledge of underlying conduction and natural pacemaker disorders. As new indications for artificial pacemaking have been elucidated, more complex pulse generators have been developed, and newer technics found for their insertion. In spite of recent development the pulse generators in general use have a limited useful lifetime. This paper reviews the indications for pacemaker insertion that are commonly employed. In addition, an approach to the problem of pulse generator replacement is presented.
Assessment of right ventricular contractile state with the conductance catheter technique in the pig
Authors: Marc L Dickstein, Osvaldo Yano, Henry M Spotnitz, Daniel Burkhoff
Journal: Cardiovascular Research (1995)

Since the conductance catheter method has facilitated evaluation of left ventricular contractile state in both laboratory and clinical studies, the aim of this study was to determine whether the technique is similarly useful for the right ventricle.A series of right ventricular pressure-volume loops was obtained in seven open chest pigs during transient vena caval occlusion using a 12-electrode conductance catheter. End systolic pressure-volume relationships, stroke work-end diastolic volume relationships, and dP/dt-end diastolic volume relationships were compared at control and during infusion of dobutamine and esmolol.Right ventricular pressure-volume loops generated with the conductance catheter were of a shape consistent with those previously reported by other volume measurement techniques, and responded to changes in inotropic state in a predictable fashion. Dobutamine shifted the three contractile relationships leftward, whereas esmolol shifted them rightward. Comparisons of stroke volume derived with the conductance catheter and with a pulmonary artery flow probe demonstrated the ability of the conductance technique to measure relative volume changes.The conductance catheter provides a continuous measure of right ventricular volume that was used to detect changes in right ventricular contractile state in pigs. This represents a promising and much needed method for the evaluation of right ventricular function.
THE NATURE AND THE SPECIFICITY OF MONONUCLEAR CELLS IN EXPERIMENTAL AUTOIMMUNE INFLAMMATIONS AND THE MECHANISMS LEADING TO THEIR ACCUMULATION
Authors: Ole Werdelin, Robert T. McCluskey
Journal: The Journal of Experimental Medicine (1971)

The nature and specificity of the mononuclear cells in passively transferred autoimmune encephalomyelitis and adrenalitis were studied. The recipients were prepared by production of a small heat lesion in the target tissue 5 days before transfer. Within 24 hr after transfer of lymph node cells from donors sensitized with the corresponding tissue antigen, a dense mononuclear cell infiltrate developed around the lesion. When lymph node cells labeled in vitro with (3)H-thymidine or (3)H-adenosine were transferred, a significant number of labeled lymphocytes was found in the infiltrate at 24 or 48 hr. Lymphocytes labeled with (3)H-thymidine showed a greater tendency to accumulate than cells labeled with (3)H-adenosine, indicating that newly formed lymphocytes were more prone to enter the reaction than older cells. Labeled lymphocytes and macrophages of recipient origin and labeled lymphocytes from donors stimulated with B. pertussis were also shown to accumulate around the heat lesion provided the reaction had been initiated by transfer of unlabeled lymphocytes from donors sensitized to the appropriate tissue-specific antigen. In recipients which were given lymph node cells from two groups of donors, sensitized either to spinal cord or to adrenal antigens, with cells from only one group of donors labeled, equal percentages of labeled cells were found around each lesion. Thus, no evidence of preferential accumulation of specifically sensitized lymphocytes was obtained. In recipients which received whole body irradiation on the day of production of the heat lesions, 5 days before transfer of lymph node cells from appropriately sensitized donors, neither monocytes nor lymphocytes accumulated around the lesion. However, if the tibial bone marrow was shielded or if bone marrow cells were given to the recipients shortly after irradiation, inflammation developed as in normal recipients. In recipients which were irradiated 24 hr after the transfer of unlabeled lymph node cells from donors sensitized to the appropriate tissue antigen and then given labeled lymph node cells from B. pertussis-stimulated donors, labeled lymphocytes were found in the reaction 24 hr later. This accumulation occurred although virtually all the lymphocytes present in the lesion at 24 hr after the first transfer were destroyed by the irradiation. The results are interpreted as follows. The autoimmune reaction is initiated by the arrival at the site of a few specifically sensitized lymphocytes, probably on a random basis. After contact with antigen, factors are produced and released which cause the influx of monocytes and of lymphocytes, in particular newly formed ones, of various specificities. There is no preferential accumulation of specifically sensitized cells. The influx of lymphocytes appears to require the presence of monocytes or macrophages in the reaction.
A Targeted Infection Prevention Intervention in Nursing Home Residents With Indwelling Devices
Authors: Lona Mody, Sarah L. Krein, Sanjay K. Saint, Lillian C. Min, Ana Montoya, Bonnie Lansing, Sara E. McNamara, Kathleen Symons, Jay Fisch, Evonne Koo, Ruth Anne Rye, Andrzej Galecki, Mohammed U. Kabeto, James T. Fitzgerald, Russell N. Olmsted, Carol A. Kauffman, Suzanne F. Bradley
Journal: JAMA Internal Medicine (2015)

Indwelling devices (eg, urinary catheters and feeding tubes) are often used in nursing homes (NHs). Inadequate care of residents with these devices contributes to high rates of multidrug-resistant organisms (MDROs) and device-related infections in NHs.To test whether a multimodal targeted infection program (TIP) reduces the prevalence of MDROs and incident device-related infections.Randomized clinical trial at 12 community-based NHs from May 2010 to April 2013. Participants were high-risk NH residents with urinary catheters, feeding tubes, or both.Multimodal, including preemptive barrier precautions, active surveillance for MDROs and infections, and NH staff education.The primary outcome was the prevalence density rate of MDROs, defined as the total number of MDROs isolated per visit averaged over the duration of a resident's participation. Secondary outcomes included new MDRO acquisitions and new clinically defined device-associated infections. Data were analyzed using a mixed-effects multilevel Poisson regression model (primary outcome) and a Cox proportional hazards model (secondary outcome), adjusting for facility-level clustering and resident-level variables.In total, 418 NH residents with indwelling devices were enrolled, with 34,174 device-days and 6557 anatomic sites sampled. Intervention NHs had a decrease in the overall MDRO prevalence density (rate ratio, 0.77; 95% CI, 0.62-0.94). The rate of new methicillin-resistant Staphylococcus aureus acquisitions was lower in the intervention group than in the control group (rate ratio, 0.78; 95% CI, 0.64-0.96). Hazard ratios for the first and all (including recurrent) clinically defined catheter-associated urinary tract infections were 0.54 (95% CI, 0.30-0.97) and 0.69 (95% CI, 0.49-0.99), respectively, in the intervention group and the control group. There were no reductions in new vancomycin-resistant enterococci or resistant gram-negative bacilli acquisitions or in new feeding tube-associated pneumonias or skin and soft-tissue infections.Our multimodal TIP intervention reduced the overall MDRO prevalence density, new methicillin-resistant S aureus acquisitions, and clinically defined catheter-associated urinary tract infection rates in high-risk NH residents with indwelling devices. Further studies are needed to evaluate the cost-effectiveness of this approach as well as its effects on the reduction of MDRO transmission to other residents, on the environment, and on referring hospitals.clinicaltrials.gov Identifier: NCT01062841.
Improvement in autonomic activity after percutaneous transluminal coronary angioplasty: Assessment by heart rate variability
Authors: Timothy Larkin, Dan Fintel, Sheridan Meyers, Bassam Moushmoush, Caryn Cochran, Paulette Niemyski, John Schaad, Jerry Weiss, Sheng-yong Huang, Donald Singer
Journal: Journal of the American College of Cardiology (1991)
Concurrent visualization of trafficking, expansion, and activation of T lymphocytes and T-cell precursors in vivo
Authors: Il-Kang Na, John C. Markley, Jennifer J. Tsai, Nury L. Yim, Bradley J. Beattie, Alexander D. Klose, Amanda M. Holland, Arnab Ghosh, Uttam K. Rao, Matthias T. Stephan, Inna Serganova, Elmer B. Santos, Renier J. Brentjens, Ronald G. Blasberg, Michel Sadelain, Marcel R. M. van den Brink
Journal: Blood (2010)