tbuckley/cabot-search huggingface dataset:
Shiitake dermatitis: the first case reported from a European country
Authors: R.K.H. Mak, S.H. Wakelin
Journal: British Journal of Dermatology (2006)

Conflicts of interest: none declared. Sir, A 37‐year‐old man had a 1‐year history of an intermittent, intensely pruritic rash. He presented during one of these episodes with a florid linear eruption on the torso. On first inspection this resembled dermographism, but individual lesions consisted of linear groups of erythematous papules in a flagellate pattern (Fig. 1). These had started on the trunk and spread peripherally to involve his limbs, the dorsa of the hands and the face. There were no mucosal abnormalities and he was not dermographic. He had an interest in oriental cookery, and on direct questioning he affirmed that he had eaten 'handfuls' of raw shiitake mushrooms 2 days before the onset of this rash and before previous episodes. The rash resolved spontaneously within a week, and routine blood tests including eosinophil count and erythrocyte sedimentation rate were normal. Based on the history and characteristic rash, we made a clinical diagnosis of shiitake dermatitis. This was confirmed by a positive oral challenge test, with typical linear pruritic lesions developing within 24 h of consuming raw mushrooms.
A RURAL COMMUNITY SOLVES ITS MEDICAL PROBLEM
Authors: Harold M. Camp
Journal: JAMA (1928)

To the Editor:  —This little story may be of interest to you, especially now that there is a real shortage of physicians in the rural communities. A small town in an adjoining county has been without a physician for the past two years. The community tried to induce a physician to locate there without success. Finally, the banker, the merchants, the minister, and a few others organized themselves as a committee to procure a physician. The bank owned a small residence with an adjoining office for a physician, and they offered to furnish this to a reputable physician, and allow him to pay for it on a monthly payment plan.  The committee called on me recently for assistance, and I at once recommended that a classified advertisement be sent toThe Journaltelling what they had to offer. The advertisement appeared in two issues. As a result, thirty-nine replies were
Iκ-B Kinase-2 Inhibitor Blocks Inflammation in Human Airway Smooth Muscle and a Rat Model of Asthma
Authors: Mark A. Birrell, Elizabeth Hardaker, Sissie Wong, Kerryn McCluskie, Matthew Catley, Jorge De Alba, Robert Newton, Saleem Haj-Yahia, K. Tao Pun, Clarissa J. Watts, Robert J. Shaw, Tony J. Savage, Maria G. Belvisi
Journal: American Journal of Respiratory and Critical Care Medicine (2005)

Nuclear factor (NF)-kappaB is a transcription factor known to regulate the expression of many inflammatory genes, including cytokines, chemokines, and adhesion molecules. NF-kappaB is held inactive in the cytoplasm, bound to I-kappaB. The removal of I-kappaB, via the actions of inhibitor of kappaB (I-kappaB) kinase-2 (IKK-2), allows NF-kappaB to enter the nucleus.To determine the impact of inhibiting IKK-2 on in vitro and in vivo models of airway inflammation.The effect of inhibiting IKK-2 was assessed in stimulated, cultured, primary human airway smooth muscle cells and an antigen-driven rat model of lung inflammation.The release of cytokines from cultured cells and inflammatory cytokine expression and cellular burden in the lung were determined.Two structurally distinct molecules and dominant negative technology demonstrated that inhibition of IKK-2 activity completely blocked cytokine release from cultured cells, whereas the two glucocorticoid comparators had limited impact on granulocyte colony-stimulating factor, interleukin 8, and eotaxin release. In addition, in an in vivo antigen-driven model of airway inflammation, the IKK-2 inhibitor blocked NF-kappaB nuclear translocation, which was associated with a reduction in inflammatory cytokine gene and protein expression, airway eosinophilia, and late asthmatic reaction, similar in magnitude to that obtained with budesonide.This study demonstrates that inhibiting IKK-2 results in a general reduction of the inflammatory response in vitro and in vivo. Compounds of this class could have therapeutic utility in the treatment of asthma and may, in certain respects, possess a beneficial efficacy profile compared with that of a steroid.
Families' Self-interest and the Cadaver's Organs
Authors: Edmund D. Pellegrino
Journal: JAMA (1991)

In a commentary in this issue of JAMA ("Life or death: the issue of payment in cadaveric organ donation"), T.G. Peters proposes a policy of paying a death benefit of $1000 to motivate the next-of-kin to consent to organ retrieval from deceased family members. Pellegrino, while sympathetic with Peters' commitment to increase the supply of donor organs and save lives, rejects the death benefit policy. He argues that Peters' proposal is based on a faulty interpretation of altruism, seriously undermines the consent process, and has too many ethical liabilities to be accepted as a policy or an experiment.
Thrombocytopenia with Decreased Megakaryocytes
Authors: DAVID B. STOLL
Journal: Annals of Internal Medicine (1981)

The presenting clinical pictures and courses of seven patients with thrombocytopenia, decreased megakaryocytes in the marrow, and minimal changes in other hematopoietic cell lines are described. Little information exists in the literature on such patients. Initial bone marrow aspiration and biopsy in all patients showed decreased megakaryocytes with an otherwise normal marrow. Erythrocyte mean corpuscular volume was elevated in five of seven patients. Bone marrow karyotypes of six of the seven patients were normal. Chromium-51 platelet survival studies with platelet sizing, done in five of the seven patients, showed normal results. In two patients the course progressed to aplastic anemia. One of these died 9 months after presentation, and one responded dramatically to lithium. One patient developed preleukemia and died. The other four patients have remained thrombocytopenic but clinically stable. No useful therapy was identified. The differential diagnosis of such patients should include idiopathic thrombocytopenic purpura with misinterpretation of morphologic findings, hereditary and acquired aplastic anemia, preleukemia, and systemic lupus erythematosus.
"All for health and health for all": a study of basic health care in Peru.
Authors: D Mansfield, A Morris
Journal: BMJ (1981)

The stratification of society is reflected in the health services in Peru.  Private medical care is excellent but the state health service is overcrowded too far for poor people to travel to and underfinanced.  The military government began a program of hospital construction in provincial towns and the Se Ci Gra program in which newly graduated doctors have to work for a year or 2 in whatever part of the country they are sent.  Increasing the number of doctors and hospitals fails to prevent disease.  Teaching the population good sanitary and nutritional practices would be a better way to help the health of the poor in rural areas.  International agencies such as the World Health Organization (WHO) supervise vaccinations and outbreaks of malign tertian malaria.  One health service emphasising education of the people is organized by 4 Benedictine monks in San Juan de Lurigancho a barrio in Lima.  Volunteer women from the parish receive training in essential health care child care nutrition and hygiene.  In the village of Lechemayo the medical auxilliary diagnoses sickness dispenses drugs vaccinates the villagers teaches schoolchildren and advises women about raising their children.  The medical auxilliarys training is much less than a doctors and his clinic lacks facilities for prolonged or intensive care.  The clinic however is an adjunct of a hospital in the larger village of San Francisco where preventive medicine is practiced.
<i>House and Street</i>
Authors: Thomas B. Cole
Journal: JAMA (2015)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Increased Expression of the E3 Ubiquitin Ligase RNF5 Is Associated with Decreased Survival in Breast Cancer
Authors: Kenneth D. Bromberg, Harriet M. Kluger, Agnes Delaunay, Sabiha Abbas, Kyle A. DiVito, Stan Krajewski, Ze'ev Ronai
Journal: Cancer Research (2007)

The selective ubiquitination of proteins by ubiquitin E3 ligases plays an important regulatory role in control of cell differentiation, growth, and transformation and their dysregulation is often associated with pathologic outcomes, including tumorigenesis. RNF5 is an E3 ubiquitin ligase that has been implicated in motility and endoplasmic reticulum stress response. Here, we show that RNF5 expression is up-regulated in breast cancer tumors and related cell lines. Elevated expression of RNF5 was seen in breast cancer cell lines that became more sensitive to cytochalasin D- and paclitaxel-induced apoptosis following its knockdown with specific short interfering RNA. Inhibition of RNF5 expression markedly decreased cell proliferation and caused a reorganization of the actin cytoskeleton in response to stress in MCF-7 but not in p53 mutant breast cancer cells, suggesting a p53-dependent function. Significantly, high levels of RNF5 were associated with decreased survival in human breast cancer specimens. Similarly, RNF5 levels were higher in metastatic melanoma specimens and in melanoma, leukemia, ovarian, and renal tumor-derived cell lines, suggesting that increased RNF5 expression may be a common event during tumor progression. These results indicate that RNF5 is a novel regulator of breast cancer progression through its effect on actin cytoskeletal alterations, which also affect sensitivity of breast cancer cells to cytoskeletal targeting antineoplastic agents.
THE SANITARY OFFICER AND COUNTY HEALTH WORK
Authors: E. L. BISHOP
Journal: JAMA (1926)

Public health work, whether dealing with environmental sanitation or personal hygiene, is essentially concerned with personal service and must therefore find the solution of its problems in personal and community relationships. Rural health work has two basic differences from urban health work. Personal relationships in rural health work are more intimate, the health worker being subjected to much closer scrutiny than is the case with urban workers. The second difference is concerned with finance. In the first place, the assessed valuation of rural areas is lower than is the case with cities, and, in addition, appropriating bodies of rural governments have not yet begun the appropriation of very large sums per capita for the protection and promotion of the public health. In a study of eighty-eight full-time county health organizations in operation throughout 1925, and serving nearly four million people, it has been shown that the total budgets represented a
A Convection-Diffusion Model of Indicator Transport through an Organ
Authors: WILLIAM PERL, FRANCIS P. CHINARD
Journal: Circulation Research (1968)

A model for interpretation of extravascular indicator dilution experiments is proposed, in which the indicator is assumed to enter the blood-tissue exchange region through vascular sources, to equilibrate instantaneously and locally between blood and tissue at the capillary-cell level, and, while maintaining this local equilibration, to be transported to vascular sinks by simultaneous diffusion and convection at a more macroscopic distance level. The model has the mathematical form of the time-dependent Fick diffusion equation to which a convection term was added. The model contains as opposite limiting cases the washout-type models and a recently proposed delayed wave model of the indicator dilution process. The various features of the extravascular indicator outflow pattern-appearance time, modal time, semi-log downslope, and dispersion about the mean-are described in terms of two parameters: (1) a diffusion parameter, square of source-to-sink distance divided by diffusion coefficient of the indicator in the tissue; (2) a convection parameter, the blood flow divided by steady-state solubility volume of distribution of the indicator in the tissue. In contrast to the preceding opposite limiting cases, the present model accounts plausibly for extravascular indicator experiments in dog kidney.
Diagnosis of Chest Pain
Authors: Peter T. Kuo
Journal: JAMA (1989)

<h3>Practical Management of Ischaemic Heart Disease, by Graham Jackson (Practical Problems in Medicine), 230 pp, with illus, $55, London, Martin Dunitz; Dobbs Ferry, NY, Sheridan House Inc, distributor, 1988,</h3> In<i>Diagnosis of Chest Pain</i>Dr Albert J. Miller encourages physicians to synthesize available information on their patients suffering from various types of chest pain for an initial working diagnosis. One can change the diagnosis with the flow of the patient's clinical and laboratory findings. Miller attempts to cover a wide range of chest pain syndromes. Under each topic he selectively reviews certain earlier reports and adds his own opinion to them. He emphasizes obtaining a good case history and careful physical examination before assessing confirmatory laboratory studies to establish the final diagnosis. Chest pain syndrome is discussed in terms of somatic, visceral, referred, and emotional types and factors. Under the "more frequent causes of chest pain," the main emphasis is
Genetics and Biosynthesis of Complement Proteins
Authors: Harvey R. Colten, Chester A. Alper, Fred S. Rosen
Journal: New England Journal of Medicine (1981)

THE complement system consists of over 20 individual plasma proteins that interact in a highly specific manner to generate elements of the inflammatory response.1 2 3 A large number of genetic polymorphisms and deficiency states of complement proteins have been recognized during the past decade.4 These observations prompted further study of the biosynthesis of complement proteins, and these studies, in turn, have led to a partial understanding of the molecular basis of the genetic control of the complement system. Moreover, clinical studies of patients with a deficiency in complement have established its central role in four different host-defense mechanisms: the generation of . . .
Value of Premixed Nitrous-oxide-and-oxygen Mixtures in the Relief of Post-operative Pain
Authors: G. D. Parbrook, B. R. Kennedy
Journal: BMJ (1964)

11 After II If At All Middle-class Eldest.. 96 6 6 11 1 8-8 Other .6-4 9.3 10-3 9.5 Manual working class <(Eldest .18 6 10-7 1615 23-1 LOther*.. 7.3 9.9 11.1 14-6 x524781; n=3; 02>P>0-1.4. The last aspect of behaviour to be considered is delin- quency.We know of all children who are brought before the courts between the ages of 8 and 17.The proportions are closely similar for those having measles before the age of 6 (4.9% delinquent) and for those having measles later or not at all (4.7% delinquent),3 so that there is no evidence that early measles is associated with troublesome behaviour in later school life. SummaryThe National Survey of Health and Development provides information about the history of measles, and the educational progress and emotional stability of 3,729 children who were followed up over a period of 15 years.There is no suggestion from this survey that children who have measles are impaired in their later educational progress.Those who get measles early, before the age of 2, do rather worse in tests of mental ability and school performance than the rest of the children, but this is sufficiently explained by their adverse home circum- stances.
Adverse Cardiovascular Events Arising From Atherosclerotic Lesions With and Without Angiographic Disease Progression
Authors: Elias A. Sanidas, Gary S. Mintz, Akiko Maehara, Ecaterina Cristea, Bertil Wennerblom, Andres Iñiguez, Jean Fajadet, Martin Fahy, Ovidiu Dressler, Giora Weisz, Barry Templin, Zhen Zhang, Alexandra J. Lansky, Bernard de Bruyne, Patrick Serruys, Gregg W. Stone
Journal: JACC. Cardiovascular imaging (2012)
Ketamine’s Success
Authors: Tracy Hampton
Journal: JAMA (2010)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Azithromycin in Chlamydial Urethritis
Authors: Raymond B. Johnson
Journal: JAMA (1993)

<h3>To the Editor.</h3> —A single 1-g dose of azithromycin has recently demonstrated effectiveness in treating uncomplicated genital chlamydial infection.<sup>1</sup>As such, azithromycin represents a major advance in the treatment of chlamydial infection and may improve our efforts to limit the spread of this important pathogen. In view of the proven efficacy of the 1-g regimen, we examined whether a lower dose (500 mg) might be as effective in treating chlamydial infection. A lower dose would cost less and might be associated with fewer side effects. Since the mean tissue concentration after a 500-mg dose of azithromycin ranges between 1 and 9 mg/kg, with levels remaining above 1 mg/kg for 2 to 3 days,<sup>2</sup>the expected tissue levels exceed the 90% minimum inhibitory concentration of<i>Chlamydia trachomatis</i>(0.25 mg/L) for at least several days.<sup>3</sup> Eleven men with nongonococcal urethritis, characterized by urethral discharge, microscopic leukocytosis, and positive rapid
NFI-A directs the fate of hematopoietic progenitors to the erythroid or granulocytic lineage and controls β-globin and G-CSF receptor expression
Authors: Linda Marie Starnes, Antonio Sorrentino, Elvira Pelosi, Monica Ballarino, Ornella Morsilli, Mauro Biffoni, Simona Santoro, Nadia Felli, Germana Castelli, Maria Laura De Marchis, Gianfranco Mastroberardino, Marco Gabbianelli, Alessandro Fatica, Irene Bozzoni, Clara Nervi, Cesare Peschle
Journal: Blood (2009)
The Pathogenesis of Autoimmune Thyroid Disease
Authors: Robert D. Utiger
Journal: New England Journal of Medicine (1991)

Autoimmune diseases are characterized by the persistent activation of immunologic effector mechanisms that alter the function and integrity of individual cells and organs. This process of abnormal self-reactivity may be initiated by environmental agents, and it probably becomes sustained because of some abnormality causing persistent T-lymphocyte activation that overrides normal tolerance of self-antigens.1 The clinical manifestations of the resulting disease may reflect tissue abnormalities due to antibody-mediated or cell-mediated immunity, or both.The clinical spectrum of autoimmune thyroid disease is very broad. Affected persons may have hyperthyroidism or hypothyroidism or may be euthyroid, with or without ophthalmopathy or goiter. The . . .
Enzymes of galactose metabolism in human hair roots
Authors: C.H.M.M. BRUYN, C. HAYMAKERS, A. WENSING, T. L.OEI, P. HOSLI
Journal: British Journal of Dermatology (1977)

Micro-methods, making use of radioactive substrates, are described for the quantitative estimation of galactokinase and galactose-1-phosphate uridyl transferase activities in lysates of hair roots obtained from the human scalp. Enzyme assays can be carried out with fractions of one hair root. Both enzymes have been investigated with regard to stability, pH optimum and Michaelis-Menten constants. Along with similarities there were also certain differences as compared to galactokinase and galactose-1-phosphate uridyl transferase activities in other human tissues. The findings were used to optimise and standardise a radiochemical micro-assay for both enzymes in human hair root lysates, applicable to carrier detection studies in galactosaemia, an inborn error of carbohydrate metabolism. Because they can easily be obtained, hair roots are a very suitable biopsy material for both fundamental and diagnostic investigations of these enzymes.
Geographic information systems: their use in environmental epidemiologic research.
Authors: M F Vine, D Degnan, C Hanchette
Journal: Environmental Health Perspectives (1997)

Advances in geographic information system (GIS) technology, developed by geographers, provide new opportunities for environmental epidemiologists to study associations between environmental exposures and the spatial distribution of disease. A GIS is a powerful computer mapping and analysis technology capable of integrating large quantities of geographic (spatial) data as well as linking geographic with nongeographic data (e.g., demographic information, environmental exposure levels). In this paper we provide an overview of some of the capabilities and limitations of GIS technology; we illustrate, through practical examples, the use of several functions of a GIS including automated address matching, distance functions, buffer analysis, spatial query, and polygon overlay; we discuss methods and limitations of address geocoding, often central to the use of a GIS in environmental epidemiologic research; and we suggest ways to facilitate its use in future studies. Collaborative efforts between epidemiologists, biostatisticians, environmental scientists, GIS specialists, and medical geographers are needed to realize the full potential of GIS technology in environmental health research and may lead to innovative solutions to complex questions.
Immunosuppressive Treatment of Idiopathic Pulmonary Hemosiderosis
Authors: Richard B. Byrd
Journal: JAMA (1973)

A young man with life-threatening idiopathic pulmonary hemosiderosis of three years'duration experienced prompt and lasting remission of his disease with the institution of immunosuppressive therapy. The response of this patient and three others reported in the literature indicates the need for further trial of this mode of therapy in this serious disease.