tbuckley/cabot-search huggingface dataset:
Abstract 18277: Role of the miR-204/miR-145 Communication in the Etiology of Pulmonary Arterial Hypertension
Authors: Audrey Courboulin, Marjorie Barrier, Sébastien Bonnet
Journal: Circulation (2011)

Introduction: Pulmonary arterial hypertension (PAH) is characterized by distal pulmonary arteries remodeling secondary to the proliferation and resistance to apoptosis of the pulmonary artery smooth muscle (PASMC). We recently described that this phenotype is associated with 7 aberrantly expressed miRNAs in PAH-PASMC. We showed that miR-204 was the most downregulated and accounts for the activation of the neoplasic axis STAT3/Pim1/NFAT, inducing PASMC proliferation and resistance to apoptosis. Because miR-204 downregulation precedes the development of PAH in chronic hypoxic mice and monocrotaline rats, we tested whether its downregulation accounts for the deregulation of the 6 others affected miRNAs in PAH. As miR-145 is implicated in systemic vascular remodeling and is the one of the most upregulated miRNA in PAH we focused our research on the regulation of miR-145 by miR-204. Methods/Results: Using lungs biopsies from 8 PAH and 8 control patients we confirmed the downregulation of miR-204 and the upregulation of miR-145 in PAH. Moreover, both miR-204 downregulation and miR-145 upregulation correlate with PAH severity. These findings were confirmed in both lungs and distal PAs of 5-MCT and 5 Sugen/Hypoxia/Normoxia rats compare to 5 control rats in which severity was assessed by CT-scan angiogram. Time to event analysis in both monocrotaline (1; 2; 3 and 4 weeks post MCT injection) and Sugen (8 and 15 weeks post Sugen) rats showed that miR-204 downregulation precedes miR-145 upregulation. In vitro using cultured human PASMC from 5 control and 3 PAH patients we showed that miR-204 upregulation in PAH-PASMC decreases miR-145; while miR-204 downregulation in control PASMC increases miR-145. Finally, in vivo nebulized MCT rats with miR-204 mimic had significantly less miR-145 compared to rats nebulized with mimic negative control. Conclusion: We demonstrated for the first time in PAH that one miRNA (miR-204) can regulate the expression of other miRNA such as miR-145. Because miR-204 downregulation precede miR-145 upregulation and PAH development, miR-204 could be considered as an early molecular marker of PAH and might represent the molecular origin of this lethal disease.
Effect of race on outcomes after allogeneic hematopoietic cell transplantation for severe aplastic anemia
Authors: Michael J. Eckrich, Kwang‐Woo Ahn, Richard E. Champlin, Peter Coccia, Kamar Godder, John Horan, David Margolis, H.Joachim Deeg, Mary Eapen
Journal: American Journal of Hematology (2013)

We compared outcomes after hematopoietic cell transplantation in patients of African American (n = 84) and Caucasian (n = 215) descent with severe aplastic anemia. African Americans and Caucasians were matched for age, donor–recipient human leukocyte antigen match, graft type, and transplantation year. The median follow‐up of surviving patients was 5 years. In multivariate analysis, overall mortality risks were higher for African Americans compared to Caucasians (relative risk 1.73, P = 0.01). The 5‐year probabilities of overall survival adjusted for interval from diagnosis to transplantation, and performance score was 58% for African Americans and 73% for Caucasians. The day‐100 cumulative incidence of grade III–IV, but not grade II–IV acute graft‐versus‐host disease (GVHD), was higher in African Americans compared to Caucasians (29% vs. 13%, P = 0.006). Although the 5‐year cumulative incidence of chronic GVHD was not significantly different between the racial groups, African Americans were more likely to have extensive chronic GVHD compared to Caucasians (72% vs. 49%, P = 0.06). Survival differences between Caucasians and African Americans can be attributed to multiple factors. Our data suggest that some of the observed survival differences between Caucasians and African Americans may be explained by higher rates of acute GVHD and severity of chronic GVHD. Am. J. Hematol. 89:125–129, 2014. © 2013 Wiley Periodicals, Inc.
Allogeneic mesenchymal stem cells prevent allergic airway inflammation by inducing murine regulatory T cells
Authors: H. Kavanagh, B. P. Mahon
Journal: Allergy (2010)

To cite this article: Kavanagh H, Mahon BP. Allogeneic mesenchymal stem cells prevent allergic airway inflammation by inducing murine regulatory T cells. Allergy 2011; 66 : 523–531. Abstract Background: Adult bone marrow‐derived mesenchymal stem cells (MSC) possess potent immune modulatory effects which support their possible use as a therapy for immune‐mediated disease. MSC induce regulatory T cells (T reg ) in vitro although the in vivo relevance of this is not clear. Objective: This study addressed the hypothesis that adult bone marrow derived‐MSC would prevent the pathology associated with allergen‐driven airway inflammation, and sought to define the effector mechanism. Methods: The influence of allogeneic MSC was examined in a model system where T reg induction is essential to prevent pathology. This was tested using a combination of a model of ovalbumin‐driven inflammation with allogeneic MSC cell therapy. Results: Systemic administration of allogeneic MSC protected the airways from allergen‐induced pathology, reducing airway inflammation and allergen‐specific IgE. MSC were not globally suppressive but induced CD4 + FoxP3 + T cells and modulated cell‐mediated responses at a local and systemic level, decreasing IL‐4 but increasing IL‐10 in bronchial fluid and from allergen re‐stimulated splenocytes. Moderate dose cyclophosphamide protocols were used to differentially ablate T reg responses; under these conditions the major beneficial effect of MSC therapy was lost, suggesting induction of T reg as the key mechanism of action by MSC in this model. In spite of the elimination of T reg , a significant reduction in airway eosinophilia persisted in those treated with MSC. Conclusion: These data demonstrate that MSC induce T reg in vivo and reduce allergen‐driven pathology. Multiple T reg dependent and independent mechanisms of therapeutic action are employed by MSC.
222. Self-Inactivating Retroviral Vectors for Gene Therapy of SCID-X1
Authors: SI Thornhill, E Grassman, M Ulaganathan, SN Waddington, SJ Howe, H Van Der Loo, A Schambach, C Kinnon, C Baum, D Williams, AJ Thrasher
Journal: Molecular Therapy (2008)
Is a strategy of intended incomplete percutaneous transluminal coronary angioplasty revascularization acceptable in nondiabetic patients who are candidates for coronary artery bypass graft surgery?
Authors: Martial G Bourassa, Kevin E Kip, Alice K Jacobs, Robert H Jones, George Sopko, Allan D Rosen, Barry L Sharaf, Leonard Schwartz, Bernard R Chaitman, Edwin L Alderman, David R Holmes, Gary S Roubin, Katherine M Detre, Robert L Frye
Journal: Journal of the American College of Cardiology (1999)
STUDIES ON THE CIRCULATION IN MAN
Authors: G. N. Stewart
Journal: The Journal of Experimental Medicine (1913)

1. In the cases of anemia studied (pernicious anemia, chlorosis, and secondary anemia) the blood flow in the hand is smaller than the normal flow. 2. Accepting Plesch's result, that the minute volume of the heart is increased in the anemias, the diminution in the hand flow is interpreted as a sign of a vasoconstriction in peripheral parts, which facilitates the increased flow through the lungs. 3. The deficiency in the hand flow is less in the chlorotic group than in the other cases of anemia. The explanation suggested is that the increased total volume of the blood in chlorosis permits the normal amount of hemoglobin to circulate through the lungs without a marked increase in the peripheral vasoconstriction. 4. The view that the diminution in the cutaneous blood flow in anemia is a necessary compensatory arrangement for increasing the flow through the lungs affords a natural explanation of the beneficial effect in many cutaneous disorders of general measures, especially those aimed at improving the quality of the blood. 5. In a case of bradycardia with a pulse rate permanently below 40 during rest in a sitting position, the hand flow was normal.
Breathing pattern and asymmetry of the rib cage in patients with hemiplegia after stroke: Comparison of breath-stacking technique and incentive spirometry
Authors: Catarina Rattes, Helga Muniz, Shirley Campos, Caio Morais, Andrea Aliverti, Thigo Gonçalves, Daniella Brandão, Guilherme Fregonezi, Armele Dornelas de Andrade
Journal: European Respiratory Journal (2014)

Background:  In hemiplegia after stroke the functionality of the respiratory system may be compromised by the presence of a restrictive breathing pattern.  Objectives:  Compare the effect of two techniques of lung expansion on the volumes of the rib cage, respiratory pattern, velocity of shortening of the diaphragm (Vdi) and volumetric differences between the hemithorax of hemiplegic subjects.  Methods:  A randomized clinical trial of crossover study was conducted with 10 volunteers, divided into two groups: incentive spirometry (GIE) and breath stacking (GBS). The subjects were evaluated by optoelectronic plethysmography in two moments: during quiet breathing and during the execution of five maneuvers of each technique.  Results:  We observed an increase in the total volume of the rib cage and its compartments during implementation of the techniques in the two groups (GBS = 278% and GIE = 313%) with greater volume contribution of the non hemiplegic side in the GIE (p l0.05). There was an increase in the respiratory cycle (GBS = 380% and GIE = 211%), (GBS = 786% and GIE = 360%), expiratory time (GBS = 109% and GIE = 105%) e and the relationship inspiratory time/ total time (GBS = 66% and GIE = 48%) in both groups (pl0.05). The Vdi was lower (p l0.05) in GBS.  Conclusions:  The results suggest that the BS technique reduces the asymmetry of the rib cage and optimizes the performance of the respiratory system during maintenance of lung volumes compared to the technique of incentive spirometry in subjects with hemiplegia following stroke.
Mumps epidemic in orthodox religious low-vaccination communities in the Netherlands and Canada, 2007 to 2009
Authors: C C Wielders, R S van Binnendijk, B E Snijders, G A Tipples, J Cremer, E Fanoy, S Dolman, W L Ruijs, H J Boot, H E de Melker, S J Hahné
Journal: Eurosurveillance (2011)

We assessed the epidemiological characteristics of a mumps virus epidemic (genotype D) that occurred in the Netherlands between August 2007 and May 2009 and its association with a subsequent mumps outbreak in Canada. In the Netherlands, five data sources were used: notifications (only mandatory since the end of 2008) (56 cases), laboratory confirmation data (177 cases), a sentinel general practitioner (GP) database (275 cases), hospitalisation data (29 cases) and weekly virological reports (96 cases). The median age of cases in the notification, laboratory and GP databases ranged from 13 to 15 years. The proportion of cases that were unvaccinated ranged from 65% to 85% in the notification, laboratory and GP databases. Having orthodox Protestant beliefs was the main reason for not being vaccinated. In Canada, a mumps virus strain indistinguishable from the Dutch epidemic strain was detected between February and October 2008 in an orthodox Protestant community with historical and family links to the affected community in the Netherlands, suggesting that spread to Canada had occurred. Prevention and control of vaccine-preventable diseases among population subgroups with low vaccination coverage remains a priority.
Dystonia: a disorder often misdiagnosed as a conversion reaction
Authors: Ronald P. Lesser, Stanley Fahn
Journal: American Journal of Psychiatry (1978)

The authors studied the records of 84 patients who had idiopathic torsion dystonia. Thirty-seven cases had originally been misdiagnosed as primarily psychiatric illness. Only 1 patient presented with dystonic movements that were clearly part of a more general psychiatric disorder. The authors believe her to be the first reported patient whose dystonia is undeniably of psychogenic origin.
A memorable patient: A vital lesson
Authors: G. Moore
Journal: BMJ (2002)

In the late 1940s, during the months before my final exams, an item pinned on the hospital notice board announced a lecture to be given by an eminent chest physician. He was a popular consultant, and audience places on such occasions were at a premium. I cleared my day for that event.

A packed auditorium greeted him. He began dramatically by speculating that only once in his long career could he claim to have saved a patient's life—a notion that challenged the …
A Distinct Signature of Natural Killer Cell KIR Gene Frequencies In Secondary AML Compared with De Novo AML and Normal Controls
Authors: Kate Stringaris, A. John Barrett, Robert Hills, David C Linch, Rosemary Gale, Christopher Allen, Paula Garland, Ruhena Sargent, Hugues de Lavallade, Abdullah Alsuliman, Ahmad Khoder, Ian H Gabriel, Takuya Sekine, Alan Burnett, Katayoun Rezvani, Jane F. Apperley
Journal: Blood (2010)
The Link Between Sauna Bathing and Mortality May Be Noncausal—Reply
Authors: Tanjaniina Laukkanen, Hassan Khan, Francesco Zaccardi
Journal: JAMA Internal Medicine (2015)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Internal Medicine HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Internal Medicine journal
Abstract 12251: Enrollment Challenges in Cardiovascular Surgical Trials: Experience of the Cardiothoracic Surgical Trials Network
Authors: Robert E Michler, A. M Gillinov, Louis P Perrault, Deborah D Ascheim, Gorav Ailawadi, Peter K Smith, Michael K Parides, Pierre Voisine, Pierre Page, Wendy C Taddei-Peters, Mary Lou Mayer, Timothy J Gardner, Irving L Kron
Journal: Circulation (2011)

Objective: The clinical research enterprise is plagued by widespread failure to meet recruitment goals in trials, and surgical trials are especially challenged. This study identifies barriers to en...
Abstract 14431: Global Loss of Id3 Leads to Increased Atherosclerosis in Western-Fed LDL Receptor Knockout Mice and Decreased Aortic B Lymphocyte Density on Optical Imaging
Authors: Michael J Lipinski, Stephanie N Oldham, Marcus D Skaflen, Kirsti A Campbell, Kimberly A Kelly, Coleen A McNamara
Journal: Circulation (2010)
Long-term Effect of Arteriovenous-fistulas (avf) Closure On Echocardiographic Parameters in Renal-transplant (tp) Patients - a Prospective-study
Authors: O. Devuvst, Michel Jadoul, Yves Pirson, D. Raphaël, Jean-Paul Squifflet, C. Vanypersele
Journal: Journal of the American Society of Nephrology (1994)
Serotonin Receptor Antagonists Have an In Vitro and In Vivo Anti-Myeloma Effect That Is Mainly Mediated by Caspase Dependent Apoptosis.
Authors: Enrique M. Ocio, Teru Hideshima, Hiroshi Yasui, Kiziltepe Tanyel, Hirosi Ikeda, Yutaka Okawa, Sonia Vallet, Janice Jin, Kenji Ishitsuka, Noopur Raje, Laurence Catley, Kenneth C. Anderson
Journal: Blood (2006)
Rickettsia spp. infection in Rhipicephalus sanguineus ticks in a Brazilian spotted fever endemic rural area in Rio de Janeiro state, Brazil
Authors: T. Rozental, A.R.M. Favacho, J.D. Barreira, R.C. Oliveira, R. Gomes, D.N.P. Almeida, E.R.S. Lemos
Journal: Clinical Microbiology and Infection (2008)
Abstract 20601: Proteomics Analysis of Extracellular Matrix Degradation in Human Abdominal Aortic Aneurysms
Authors: Athanasios Didangelos, Kaushik Mandal, Xiaoke Yin, Angelika Saje, Marjan Jahangiri, Manuel Mayr
Journal: Circulation (2010)

Background: Although proteomics has been previously applied to vascular tissues, none of these studies has specifically targeted the vascular extracellular environment. Methods and Results: We deve...
Brain response to protein undernutrition
Authors: Peter R. Dallman, Robert A. Spirito
Journal: Journal of Clinical Investigation (1972)

This study was designed to determine how the brain, in contrast to most other tissues, maintains an almost normal protein content during a period of dietary protein deficiency. Administration of leucine-(3)H to rats was started during a period of early development (6-18 days) which is characterized by disproportionately rapid brain growth; later (24-33 days) leucine-(14)C was administered, when brain growth diminishes but total body weight gain continues to be rapid. At 35 days of age the ratio of (3)H:(14)C in cerebrum, cerebellum, and brain stem protein averaged between 1.63 and 1.82. In skeletal muscle, liver, myocardium, and intestinal mucosa the mean (3)H:(14)C was 1.07 or less. Then, a diet containing either 26% or 3.4% protein was administered. In animals fed the 26% protein diet, (3)H:(14)C in the three brain segments remained essentially unchanged over a 42 day period. In contrast, in the 3.4% protein group (3)H:(14)C in brain decreased to values approaching those of other tissues in the body: cerebrum, 1.18; cerebellum, 1.20; and brain stem, 1.16. The results suggest that conservation of brain protein is not due entirely to the long life-span of its cellular components or to efficient reutilization of the products of protein catabolism but through utilization of amino acids from degradation of protein elsewhere in the body.
Statins as the new aspirin
Authors: U. Ravnskov
Journal: BMJ (2002)

Successful leadership requires range of stylesEditor-Treasure's views and comments after the NHS Confederation's leadership conference make interesting reading. 1 The leadership style of consultants covers a broad spectrum that could be described as ranging from "huggy touchy feely" all the way up to "Attila the Hun meets Genghis Khan."A similar spectrum exists in managers.The British government's own Cabinet Office expert report on public service leadership indicates that successful leaders need to adopt a range of styles depending on the situation. 2That may include having to resort at times to coercive, browbeating styles.Many consultants would perhaps choose to operate in the lower or middle range of the style spectrum.At times when managers do not listen to consultants' reasonable concerns about the delivery of safe, effective, high quality services there may be no option but reluctantly to wheel out Attila and Genghis to protect both patients and consultants.Treasure is very fortunate to be in a specialty that is comparatively rich in resources and having its concerns addressed by major
The Consult Guys - Shoot From the Hip? Surgery With Aortic Stenosis
Authors: Geno J. Merli, Howard H. Weitz
Journal: Annals of Internal Medicine (2015)

Web Exclusives18 August 2015The Consult Guys - Shoot From the Hip? Surgery With Aortic StenosisFREEGeno J. Merli, MD and Howard H. Weitz, MDGeno J. Merli, MDSearch for more papers by this author and Howard H. Weitz, MDSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/G15-3008 SectionsSupplemental MaterialAboutVisual Abstract ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail The Consult Guys bring a new perspective to the art and science of medicine with lively discussion and analysis of real-world cases and situations.For more videos from and information on The Consult Guys, visit www.annals.org/ConsultGuys. Comments0 CommentsSign In to Submit A Comment Author, Article, and Disclosure InformationAffiliations: Disclosures: Geno J. Merli, MD, reports the following: Research grants/contracts: Bristol-Myers Squibb, Janssen, Portola; Consultancies: Bristol-Myers Squibb, Janssen. Howard H. Weitz, MD, reports that he has no financial relationships or interests to disclose.Editors' Disclosures: Christine Laine, MD, MPH, Editor in Chief, reports that she has no financial relationships or interests to disclose. Darren B. Taichman, MD, PhD, Executive Deputy Editor, reports that he has no financial relationships or interests to disclose. Cynthia D. Mulrow, MD, MSc, Senior Deputy Editor, reports that she has no relationships or interests to disclose. Deborah Cotton, MD, MPH, Deputy Editor, reports that she has no financial relationships or interest to disclose. Jaya K. Rao, MD, MHS, Deputy Editor, reports that she has stock holdings/options in Eli Lilly and Pfizer. Sankey V. Williams, MD, Deputy Editor, reports that he has no financial relationships or interests to disclose. Catharine B. Stack, PhD, MS, Deputy Editor for Statistics, reports that she has stock holdings in Pfizer. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 18 August 2015Volume 163, Issue 4Page: CG1KeywordsDisclosureHipResearch grantsResearch reporting guidelinesStenosisSurgery ePublished: 18 August 2015 Issue Published: 18 August 2015 Copyright & PermissionsCopyright © 2015 by American College of Physicians. All Rights Reserved.Loading ...
Population Trends in Percutaneous Coronary Intervention
Authors: Marieke L. Fokkema, Stefan K. James, Per Albertsson, Axel Akerblom, Fredrik Calais, Peter Eriksson, Jens Jensen, Tage Nilsson, Bart J. de Smet, Iwar Sjögren, Björn Thorvinger, Bo Lagerqvist
Journal: Journal of the American College of Cardiology (2013)
Evaluation of different patterns of high frequency spinal cord stimulation (HF-SCS) to activate the inspiratory muscles
Authors: Krzysztof Kowalski, Anthony DiMarco
Journal: European Respiratory Journal (2011)

Background:  HF-SCS is a novel method of inspiratory muscle activation and may be a useful method to support artificial ventilation. In this study, the effects of different patterns of HF-SCS on inspiratory muscle activation were compared to spontaneous breathing (SB).   Methods:  In 3 anesthetized dogs, single motor unit (SMU) activity of the diaphragm (D) and parasternal muscles (P) were assessed during SB and HF-SCS at the T2 level with ramp and non-ramp stimulation by measuring a) time of onset (To) and b) time to peak firing frequency (TTP) of SMUs. To and TTP were determined relative to the onset of inspiratory flow and expressed as a percentage of inspiratory time (Ti).   Results:  During SB, mean onset of D and P were8.0±1.1 and 14.2±2.0%Ti, respectively. During non-ramp HF-SCS, To was 1.7±0.7 and 2.4±0.3%Ti for D and P, respectively (p  Mean peak firing frequencies of D and P during both HF-SCS and SB were not different. During SB, TTP was 74.0±8.7 and 71.5±6.9%Ti for D and P. During non-ramp HF-SCS, TTP was 10.6±3.1 and 15.8±3.5%Ti, for D and P (p   Conclusion:  Activation of the inspiratory motoneuron pools via HF-SCS is responsive to different patterns of electrical stimulation. Ramp HF-SCS compared to non-ramp HF-SCS results in a more physiologic method of inspiratory muscle activation.  Support: NIH-NINDS (R01NS064157).   Disclosure:  Dr.DiMarco has a significant financial interest in Synapse BioMedical, Inc, a manufacturer of diaphragm pacing systems.