tbuckley/cabot-search huggingface dataset:
Screening for Prostate Cancer
Authors: Roger Chou, Jennifer M. Croswell
Journal: Annals of Internal Medicine (2012)

Letters3 April 2012Screening for Prostate CancerRoger Chou, MD and Jennifer M. Croswell, MD, MPHRoger Chou, MDFrom Oregon Health & Science University, Portland, OR 97239, and Agency for Healthcare Research and Quality, Rockville, MD 20850.Search for more papers by this author and Jennifer M. Croswell, MD, MPHFrom Oregon Health & Science University, Portland, OR 97239, and Agency for Healthcare Research and Quality, Rockville, MD 20850.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-156-7-201204030-00017 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail IN RESPONSE:We appreciate the interest in our review. We would like to clarify that the purpose of the review was to synthesize the evidence on benefits and harms of prostate cancer screening, not to make recommendations about screening. The article was not written by the USPSTF but was commissioned and used by the USPSTF to inform its separate draft recommendation.Dr. Carlsson and colleagues incorrectly state that the review's conclusions are based on the results of 2 published meta-analyses. In fact, our review reports and summarizes the results of the 2 major screening trials (ERSPC [1] and PLCO [2]) ...References1. Schröder FH, Hugosson J, Roobol MJ, Tammela TL, Ciatto S, Nelen V, et al; ERSPC Investigators. Screening and prostate-cancer mortality in a randomized European study. N Engl J Med. 2009;360:1320-8. [PMID: 19297566] CrossrefMedlineGoogle Scholar2. Andriole GL, Crawford ED, Grubb RL, Buys SS, Chia D, Church TR, et al; PLCO Project Team. Mortality results from a randomized prostate-cancer screening trial. N Engl J Med. 2009;360:1310-9. [PMID: 19297565] CrossrefMedlineGoogle Scholar Author, Article, and Disclosure InformationAffiliations: From Oregon Health & Science University, Portland, OR 97239, and Agency for Healthcare Research and Quality, Rockville, MD 20850.Disclosures: Disclosures can be viewed at www.acponline.org/authors/icmje/ConflictOfInterestForms.do?msNum=M11-1085. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoScreening for Prostate Cancer: A Review of the Evidence for the U.S. Preventive Services Task Force Roger Chou , Jennifer M. Croswell , Tracy Dana , Christina Bougatsos , Ian Blazina , Rongwei Fu , Ken Gleitsmann , Helen C. Koenig , Clarence Lam , Ashley Maltz , J. Bruin Rugge , and Kenneth Lin Screening for Prostate Cancer Sigrid Carlsson , Andrew Vickers , Hans Lilja , and Jonas Hugosson Screening for Prostate Cancer M'Liss A. Hudson Screening for Prostate Cancer Murray S. Feldstein Metrics 3 April 2012Volume 156, Issue 7Page: 540KeywordsCancer screeningCancer treatmentPopulation statisticsProstate cancerProstate diseasesQuality of lifeRadiation therapySurgery ePublished: 3 April 2012 Issue Published: 3 April 2012 Copyright & PermissionsCopyright © 2012 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
BAC array analysis of single disseminated tumor cells from bone marrow of breast cancer patients
Authors: Christine Fuhrmann, Oleg Schmidt-Kittler, Karina Petat-Dutter, Nikolas H. Stoecklein, Christian Vay, Kerstin Bockler, Christoph A. Klein
Journal: Cancer Research (2006)

Proc Amer Assoc Cancer Res, Volume 47, 2006

4194 

Death from cancer is often due to metastases arising from heterogeneous disseminated cancer cells that comprise therapy resistant cell clones. To overcome selection of variant cells by adjuvant therapies it is therefore necessary to search for and target common mutations shared by all disseminated cancer cells. Most likely only early mutations that occur prior to dissemination fulfill this postulate and are transmitted to all cells eventually found throughout the organism. In an attempt to define DNA changes shared among the progenitor cells of metastasis, we isolated and characterized single disseminated cancer cells from the bone marrow of breast cancer patients. To identify genomic regions affected by early DNA damage we therefore developed a protocol for array-based CGH of single cells. The novel technique should enable the detection of numerical imbalances in single cells and thereby increases cellular resolution of array / matrix-CGH at least 1.000 fold. Various methods of array preparation were compared with standard array-CGH. Additionally, oligo-arrays were tested and were not suited for single-cell DNA in our hands. While large amounts of unamplified DNA were suited for all standard arrays, chromosomal aberrations could not be retrieved when single-cell DNA was hybridized. We therefore developed an optimized protocol for BAC preparation, single-cell DNA-labeling, and hybridization and applied it successfully to single cells. We tested single normal cells from healthy donors, single leukocytes from patients with trisomy 21 and single disseminated tumor cells from bone marrow of breast cancer patients. While single normal cells displayed a normal karyotype, copy number ratios of 3:2 for chromosome 21 were readily detected in single leukocytes from a patient with trisomy 21. The novel 3K single cell BAC array with a resolution of 1Mb now enables whole-genome characterization of early progenitor cells of metachronic metastasis.
Abstract 3160: The Initial Slope of the VO2/VCO2 Curve (s1) in Cardiopulmonary Exercise Testing is the Strongest Predictor of Outcome in Patients with Chronic Post-Infarction Heart Failure
Authors: Joerg Honold, Lenka Geiger, Birgit Assmus, Ulrich Fischer-Rasokat, Volker Schaechinger, Ioakim Spyridopoulos
Journal: Circulation (2006)

Prognosis of chronic heart failure (HF) remains poor despite novel therapeutic strategies, making identification of parameters to detect patients (pts) at risk a major goal. We assessed 103 HF-pts ...
Eroding Amyloid Deposits
Authors: Joan Stephenson
Journal: JAMA (2002)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Blood cholesterol and vascular mortality by age, sex, and blood pressure: a meta-analysis of individual data from 61 prospective studies with 55 000 vascular deaths
Authors: Sarah Lewington, Gary Whitlock, Robert Clarke, Paul Sherliker, Jonathan Emberson, Jim Halsey, Nawab Qizilbash, Richard Peto, Rory Collins
Journal: The Lancet (2007)
Abstract 16848: Evolving Standards for Athlete ECG Interpretation Result in Declining Abnormal Rates
Authors: Joseph C Marek, Kathleen A Marek, Johneen Davis, Ziad Sinno, Frank Zimmerman
Journal: Circulation (2014)

Introduction: ECG screening of athletes is believed to be effective in addressing the issue of sudden cardiac death (SCD) in young athletes. One criticism against screening has been the concern for a high percentage of abnormal ECG findings recently reported to be as high as 21.8%. The prevalence of conditions believed to be responsible for SCD is 0.3-0.7%. Since 2007 there have been several modifications of interpretation standards. Hypothesis: We hypothesized that these changing standards in addition to increased experience reading screening ECGs would reduce the abnormal ECG rate in our screening program and bring it closer to the expected prevalence of SCD causing conditions. Methods: The Young Hearts for Life (YH4L) ECG screening program has been performing ECGs on young athletes in the Chicago region since 2006. Interpretation was limited to six cardiologists experienced in the interpretation of adolescent ECGs and possessing knowledge of the ECG changes that occur in conditions associated with SCD. Two of these cardiologists read 90% of the total ECGs during the study. As new standards and research for interpretation were published, they were incorporated into the YH4L screening protocol. The annual abnormal rate for screening ECGs was compiled from 2006-2014. Results: A total of 108,057 ECGs were performed from 2006-2014 on young athletes age 14-19. The abnormal ECG rate gradually declined as the new interpretation standards were employed (see graph). The highest abnormal ECG rate of 2.43% was seen in the early period of the screening program (2007) compared to the rate of 1.00% seen during the most recent ECG screening (2014). The abnormal ECG rate was reduced by 59% over the 8 year time period (p&lt;0.001). Conclusions: Greater experience and evolving standards for interpretation of screening ECGs in young athletes have resulted in a 59% reduction in abnormal rates found in the YH4L screening program. This rate is closer to expected prevalence of SCD causing conditions.
Could smoke-free end passive smoking in Istanbul, Turkey?
Authors: Elif Dagli, Pinar Ay, Efza Evrengil, Murat Güner
Journal: European Respiratory Journal (2014)

In Turkey smoking in all indoor workplaces and public places is banned since July 2009 with the law.Observations indicated that although the law was respected well during its first years of implementation, compliance rates declined thereafter.  The aim of this study is to determine the compliance to the smoke-free law in enclosed spaces of hospitality establishments in Istanbul.  This study was designed as a cross-sectional survey. 450 establishments were observed in 30 clusters. Restaurants and cafes constituted the majority of the observed establishments. Of all, 184 (40.9 %) establishments had open terraces and 159 (35.3%) had extensions with removable panels. Among all only 298 (66.2%) had no-smoking signs.  Consumption of cigarettes was directly observed in 155 (34.4%) of the establishments. Cigarette butts were detected in 89 (19.8%). Existence of ashtrays and ashtray substitutes were documented in 169 (37.6%) and 23 (5.1%) establishments, respectively. When ashtrays and cigarette butts were considered as violation, then the total rate of smoke-free violation increased to 49.5 %.  Smoke-free violations in enclosed spaces of hospitality establishments are alarmingly high. Violations are significantly higher at establishments featuring extensions with removable panels and ventilation systems, and at those which predominantly cater to younger clients, all indicating an organized trend of smoke-free violation. Unlike the common perception, service of alcoholic beverages does not increase rate of smoke-free violations.The number of fines issued are low and they do not deter establishments from violating the law.Existing methods of enforcement are inadequate in ensuring compliance with the law.
Comparison of preschool vision screening tests as administered by licensed eye care professionals in the vision in preschoolers study*1
Authors: Paulette Schmidt, Maureen Maguire, Velma Dobson, Graham Quinn, Elise Ciner, Lynn Cyert, Marjean Taylor Kulp, Bruce Moore, Deborah Orel-Bixler, Maryann Redford, Gui-shuang Ying
Journal: Ophthalmology (2004)
RAPID RESPONSES FROM BMJ.COM
Authors: John Rand Neuenschwander
Journal: BMJ (2003)

From BMJ USA 2003;April:219 

Editor—Physicians trust that all articles in reputable journals offer reliable statistics, verifiable conclusions, and stringent peer review. My esteem for the BMJ, and more recently, BMJ USA, ends with the publication of “Empty arms: the effect of the arms trade on mothers and …
CD Rom: The National Research Register
Authors: I. Roberts
Journal: BMJ (1998)

NHS Executive Update Software, available free from the NHS Executive Rating:![Graphic][1]</img>![Graphic][2]</img>![Graphic][3]</img>(![Graphic][4]</img>![Graphic][5]</img>![Graphic][6]</img>![Graphic][7]</img>for promise![Graphic][8]</img>![Graphic][9]</img>for product) The public pays for the NHS, and for the NHS research and development programme. This is more than adequate justification for making information on research projects taking place within the NHS publicly available. The National Research Register is a CD ROM containing five research databases: ( a ) a database of projects funded by the NHS Executive, ( b ) a database of trials funded by the Medical … [1]: /embed/inline-graphic-1.gif [2]: /embed/inline-graphic-2.gif [3]: /embed/inline-graphic-3.gif [4]: /embed/inline-graphic-4.gif [5]: /embed/inline-graphic-5.gif [6]: /embed/inline-graphic-6.gif [7]: /embed/inline-graphic-7.gif [8]: /embed/inline-graphic-8.gif [9]: /embed/inline-graphic-9.gif
Feeding the preterm infant
Authors: William McGuire, Ginny Henderson, Peter W Fowlie
Journal: BMJ (2004)

Providing appropriate nutrition for growth and development is a cornerstone of the care of preterm infants. Early postnatal nutrition during this critical period of brain growth may have a substantial impact on clinically important outcomes, including long term neurodevelopment.

Preterm infants, especially those who have been growth restricted in utero, have fewer nutrient reserves at birth than term infants. Additionally, preterm infants are subject to physiological and metabolic stresses that can affect their nutritional needs, such as respiratory distress or infection. An international consensus group has recommended nutritional requirements for preterm infants. These recommendations are based on data from intrauterine growth and nutrient balance studies and assume that the optimal rate of postnatal growth for preterm infants should be similar to that of normal fetuses of the same postconception age. In practice, however, these target levels of nutrient input are not always achieved and this may result in important nutritional deficits.

View this table:

Nutritional requirements for preterm infants*



Well infants of gestational age > 34 weeks are usually able to coordinate sucking, swallowing, and breathing, and so establish breast or bottle feeding. In less mature infants, oral feeding may not be safe or possible because of neurological immaturity or respiratory compromise. In these infants milk can be given as a continuous infusion or as an intermittent bolus through a fine feeding catheter passed via the nose or the mouth to the stomach.

### Necrotising enterocolitis

A major concern with the introduction of enteral feeds (especially to very preterm, growth restricted, or sick infants) is that the additional physiological strain on the immature gastrointestinal tract may predispose to the development of necrotising enterocolitis. The risk of necrotising …
Favorable Therapeutic Responses in Newly Diagnosed CML-CP Patients Induced by Dasatinib Are Reflected At the CD34+CD38+ Progenitor Cell but Not At the CD34+CD38− Stem Cell Level: Results From Randomized NordCML006 Study
Authors: Satu Mustjoki, Johan Richter, Gisela Barbany, Hans Ehrencrona, Ingunn Dybedal, Thoas Fioretos, Tobias Gedde-Dahl, Bjorn Gjertsen, Randi Hovland, Sari E Jalkanen, Dag Josefsen, Perttu Koskenvesa, Carin Lassen, Kirsi Latvala, Waleed Majeed, Claes Malm, Berit Markevärn, Ali Mosfegh, Lotta Ohm, Tor Olofsson, Ulla Olsson-Strömberg, Katrin Rapakko, Kari Remes, Jesper Stentoft, Leif Stenke, Merja Suominen, Sara Thunberg, Ole Weiss Bjerrum, Bengt Simonsson, Kimmo Porkka, Henrik Hjorth-Hansen
Journal: Blood (2011)
Teaching of fertility regulation in medical schools. Survey in the United States and Canada, 1964
Authors: C. Tietze
Journal: JAMA (1966)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Abstract 11927: Paracrine Engineering of Human Cardiac Stem Cells to Over-Express Stromal Cell-Derived Factor 1α Enhances Post-Ischemic Cardiac Repair
Authors: Everad L Tilokee, Nicholas Latham, Robyn Jackson, Audrey E Mayfield, Bin Ye, Bu-Khanh Lam, Marc Ruel, Erik J Suuronen, Duncan J Stewart, Darryl R Davis
Journal: Circulation (2014)

Introduction:  First generation cardiac stem cell (CSC) products provide indirect cardiac repair but variably produce key cardioprotective cytokines (such as stromal-cell derived factor 1α (SDF1α)) which opens the prospect of maximizing up-front paracrine-mediated repair.   Methods/Results:  The mesenchymal sub-population within human CSCs underwent lentiviral (lv) mediated gene transfer of SDF1α. Cytokine array profiling revealed that SDF1α over-expression prevented lv-mediated “loss of cytokines” through autocrine stimulation of the 47±4% CXCR4+ CSCs. SDF1α enhanced angiogenesis and stem cell recruitment while priming CSCs to readily adopt a cardiac identity. As compared to injection with unmodified CSCs, transplant of SDF1α transduced CSCs into NOD SCID mice improved myocardial function (4 week LVEF: 39±2 vs. 33±1%; p≤0.05) and angiogenesis (4±0.7 vs. 2±0.5 isolectin b4+ve vessels/field; p≤0.05) while reducing scarring (4.0±0.2 vs. 5.8±0.7%, p≤0.05). Infarct, infarct border and off-target regions demonstrated greater SDF1α content (7 days post injection: 51±12, 7±1 and 16±5 fold increased vs. unmodified CSCs, p≤0.05) which paralleled reductions in myocyte apoptosis (i.e., increased Bcl-2 to Bax ratio disparity) but did not influence long-term CSC engraftment or the fate of transplanted cells. BrdU pulsing revealed that transplantation of SDF1α transduced CSCs increased the generation of new myocytes (BrdU+/TnT+; 1.4±0.1 fold increase vs. unmodified CSCs; p=0.02). A murine sex mismatch bone marrow transplant model confirmed that transplant of unmodified CSCs did not increase recruitment of bone marrow cells (vs. PBS injection alone) while transplant of SDF1α transduced CSCs increased bone marrow cell recruitment by 2.3±0.5 and 1.5±0.3 fold at 7 (p≤0.05) and 14 (p=0.08) days after CSC injection as compared to transplant of unmodified CSCs.   Conclusions:  Paracrine engineering of human CSCs to over-express SDF1α enhances recruitment of endogenous stem cells, new myocyte/vessel formation and salvage of reversibly damaged myocardium to enhance cardiac repair after experimental MI.
Baseline Subclinical Atherosclerosis Burden and Distribution Are Associated With Frequency and Mode of Future Coronary Revascularization
Authors: Michael G. Silverman, James R. Harkness, Ron Blankstein, Matthew J. Budoff, Arthur S. Agatston, J. Jeffrey Carr, Joao A. Lima, Roger S. Blumenthal, Khurram Nasir, Michael J. Blaha
Journal: JACC. Cardiovascular imaging (2014)
An old problem
Authors: A Breck McKay, Daryl Wall
Journal: BMJ (2008)

Forgacs and Loganayagam described the problem of overprescribing proton pump inhibitors (PPIs).1 In June 2002 we wrote to many journals—and were ignored—about long term side effects being identified in general practice and surgery patients, with the then extensive, long term use of PPIs. At the time we shared an increasing number of patients with dependence on PPIs who experienced acute, severe gastritis and …
Development of a protocol to evaluate the quality of clinical influenza data collected by sentinel practitioners in Europe
Authors: J F Aguilera, W J Paget, J Van Der Velden
Journal: Eurosurveillance (2002)

EISS implemented an evaluation protocol to assess the quality of clinical data collected by sentinel networks for the surveillance of influenza. The protocol was applied in Belgium and in three regions in Spain where it resulted in recommendations to improve the national and regional surveillance networks.
Family functioning and major depression: an overview
Authors: G I Keitner, I W Miller
Journal: American Journal of Psychiatry (1990)

The authors review the evidence supporting the idea that the family plays a major role in the development and course of major depression. They find that the family pathology evident during an acute depressive episode continues after the patient's remission; that the course of depressive illness, relapse rates, and suicidal behavior are all affected by family functioning; and that children of depressed parents are at high risk for psychopathology. The authors explore unresolved issues regarding our understanding of the factors mediating the interaction between major depression and family functioning, concluding that there is evidence to support family and marital interventions, particularly in the treatment of depressed women.
Targeting NF-κB in Waldenstrom macroglobulinemia
Authors: Xavier Leleu, Jérôme Eeckhoute, Xiaoying Jia, Aldo M. Roccaro, Anne-Sophie Moreau, Mena Farag, Antonio Sacco, Hai T. Ngo, Judith Runnels, Molly R. Melhem, Nicolas Burwick, Abdelkareem Azab, Feda Azab, Zachary Hunter, Evdoxia Hatjiharissi, Daniel R. Carrasco, Steven P. Treon, Thomas E. Witzig, Teru Hideshima, Myles Brown, Kenneth C. Anderson, Irene M. Ghobrial
Journal: Blood (2008)
Prevention of acute kidney injury and protection of renal function in the intensive care unit
Authors: Michael Joannidis, Wilfred Druml, Lui G. Forni, A. B. Johan Groeneveld, Patrick Honore, Heleen M. Oudemans-van Straaten, Claudio Ronco, Marie R. C. Schetz, Arend Jan Woittiez
Journal: Intensive Care Medicine (2009)
Delayed Hypersensitivity Skin Testing of 150 Volunteers
Authors: P. Neuvonen, M. Salo, M. Viljanen, I. Helander
Journal: Allergy (1985)

We studied skin test reactivity to five commonly used antigens by testing 150 healthy adults. The delayed hypersensitivity (DH) skin test is widely used to assess the immune status of patients. The battery of antigens suitable for use may vary in different countries, but the reactivity to the antigens in our population did not differ remarkably from reports of other authors. The reactivity rates were: candida 32.7%, mumps 86%, streptokinase-streptodornase (SK-SD) 70%, trichophyton 0% and tuberculin 58.7%. Sixteen of the subjects were retested after 2 weeks. Only eight of them showed unchanged reactions to all five antigens. Specific IgG antibody concentrations measured by enzyme-linked immunosorbent assay (ELISA) against each of the five antigens in the serum of 42 subjects before and after testing showed great inter-individual variation. The antibody concentration did not correlate with the DH skin test results, but the testing itself increased the production of anti-mumps- and anti-SK-SD-antibodies.