CONGENITAL SERUM PROTHROMBIN CONVERSION ACCELERATOR (SPCA) DEFICIENCY
Authors: H A DANN, H W FISHER, L BURNETT, D BRIGGS
Journal: Annals of Internal Medicine (1958)

Case Reports1 August 1958CONGENITAL SERUM PROTHROMBIN CONVERSION ACCELERATOR (SPCA) DEFICIENCYHERBERT A. DANN, M.D., HYMAN W. FISHER, M.D., LEE BURNETT, M.S., DONALD BRIGGS, M.D.HERBERT A. DANN, M.D.Search for more papers by this author, HYMAN W. FISHER, M.D.Search for more papers by this author, LEE BURNETT, M.S.Search for more papers by this author, DONALD BRIGGS, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-49-2-459 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptINTRODUCTIONIt became apparent a decade ago that the conversion of prothrombin to thrombin does not occur solely with the aid of thromboplastin and calcium. Ware and his colleagues1-4separated a protein fraction from bovine serum, serum AC-globulin, which they thought resulted from the interaction of thrombin with a relatively inert precursor, plasma AC-globulin. This increased the velocity and amount of thrombin formation in an isolated system containing prothrombin, thromboplastin and calcium. Owren5found a similar substance evolving during the coagulation process and called it factor VI. Alexander et al.6-9reported on a prothrombin conversion accelerator in serum, SPCA. Milstone10...Bibliography1. WareGuestSeegers AGMMWH: A factor in plasma which accelerates the activation of prothrombin, J. Biol. Chem. 169: 231, 1947. CrossrefMedlineGoogle Scholar2. WareMurphySeegers AGRCWH: The function of AC-globulin in blood clotting, Science 106: 618, 1947. CrossrefMedlineGoogle Scholar3. WareSeegers AGWH: Serum accelerator globulin: quantitative determination, purification and properties, Federation Proc. 7: 131, 1948. MedlineGoogle Scholar4. WareSeegers AGWH: Plasma accelerator globulin: partial purification, quantitative determination and properties, J. Biol. Chem. 172: 699, 1948. CrossrefMedlineGoogle Scholar5. 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AlexanderGoldstein BR: Coagulation defect in hepatic disorders: deficiency of prothrombin-conversion accessory substances, J. Clin. Investigation 29: 795, 1950. MedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: *Received for publication February 5, 1957.From the Department of Medicine of the New York University Post-Graduate Medical School, New York, N. Y.Requests for reprints should be addressed to Herbert A. Dann, M.D., 863 Park Avenue, New York 21, N. Y. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byFactor VII deficiencyCongenital "Hypoprothrombinemias": Deficiency of Factors II, VII, and XClinical aspects of congenital factor VII deficiencyCongenital deficiency of factor VII (hypoconvertinemia)Clotting Factor VII (Proconvertin): Synonymy, Properties, Clinical and Clinicolaboratory Aspects 1 August 1958Volume 49, Issue 2Page: 459-466KeywordsBlood plasmaCalciumPlasma proteinsSerum proteinsThrombin Issue Published: 1 August 1958 PDF downloadLoading ...