Medical Therapy for Reflux Esophagitis: 1986 and Beyond
Authors: DONALD O. CASTELL
Journal: Annals of Internal Medicine (1986)

Editorials1 January 1986Medical Therapy for Reflux Esophagitis: 1986 and BeyondDONALD O. CASTELL, M.D.DONALD O. CASTELL, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-104-1-112 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptChronic gastroesophageal reflux, primarily manifested by heartburn, has been estimated to produce daily symptoms in up to 10% of the U. S. population. In the past decade considerable investigative efforts have been applied toward greater understanding of the pathophysiology of this condition and therapy for it. This activity has been fruitful, producing a number of new therapies, some of which are now widely used and some of which have future potential. The medical treatment of reflux esophagitis in the mid-1970s consisted of a few modifications of the patient's lifestyle and the addition of antacids. These approaches, called phase 1 therapy...References1. BEHARSHEAHANBIANCANISPIROSTORER JDPHE. Medical and surgical management of reflux esophagitis: a 38-month report of a prospective clinical trial. N Engl J Med. 1975;293:263-8. CrossrefMedlineGoogle Scholar2. BEHARBRANDBROWN JDF. Cimetidine in the treatment of symptomatic gastroesophageal reflux: a double blind controlled trial. Gastroenterology. 1978;74(2 pt 2):441-8. CrossrefMedlineGoogle Scholar3. WESDORPDEKKERKLINKENBERG-KNOL IWE. Treatment of reflux oesophagitis with ranitidine. Gut. 1983;24:921-4. CrossrefMedlineGoogle Scholar4. FARRELLROLINGCASTELL RGD. Cholinergic therapy of chronic heartburn: a controlled trial. Ann Intern Med. 1974;80:573-6. LinkGoogle Scholar5. MCCALLUMIPPOLITICOONEYSTURDEVANT RACR. A controlled trial of metoclopramide in symptomatic gastroesophageal reflux. N Engl J Med. 1977;296:354-7. CrossrefMedlineGoogle Scholar6. CASTELL D. Medical therapy of reflux esophagitis [Editorial]. Ann Intern Med. 1980;93:926-7. LinkGoogle Scholar7. LIEBERMANKEEFFE DE. Treatment of severe reflux esophagitis with cimetidine and metoclopramide. Ann Intern Med. 1986;104:21-6. LinkGoogle Scholar8. BRIGHT-ASAREEL-BASSOUSSI PM. Cimetidine, metoclopramide, or placebo in the treatment of symptomatic gastroesophageal reflux. J Clin Gastroenterol. 1980;2:149-56. CrossrefMedlineGoogle Scholar9. TEMPLEBRADBYO'CONNOR JGF. Cimetidine and metoclopramide in oesophageal reflux disease. Br Med J [Clin Res]. 1983;286:1863-4. CrossrefMedlineGoogle Scholar10. SACOORLANDOLEVINSONBOZYMSKIJONESFRAKES LRSEJJ. Double-blind controlled trial of bethanechol and antacid versus placebo and antacid in the treatment of erosive esophagitis. Gastroenterology. 1982;82:1369-73. CrossrefMedlineGoogle Scholar11. SCHWEITZERBASSJOHNSONHARMON EBLJ. Sucralfate prevents experimental peptic esophagitis in rabbits. Gastroenterology. 1985;88:611-9. CrossrefMedlineGoogle Scholar12. KATZGEISINGERWUHASSANCASTELL PKWMD. Acid-induced esophagitis in cats: cytoprotection by sucralfate [Abstract]. Gastroenterology. 1985;88(5 pt 2):1438. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Bowman Gray School of Medicine of Wake Forest University Winston-Salem, North Carolina PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByInfluence of prucalopride on esophageal secondary peristalsis in reflux patients with ineffective motilityA Case Report on Soojeom-san plus Jeungmiyijin-tang for Treatment of Gastroesophageal Reflux Disease with Hiatal HerniaEffects of mosapride on secondary peristalsis in patients with ineffective esophageal motilityRelevance of mild ineffective oesophageal motility (IOM) and potential pharmacological reversibility of severe IOM in patients with gastro-oesophageal reflux diseaseNon–Rapid Eye Movement Sleep ParasomniasNREM SLEEP PARASOMNIASReflux Esophagitis: OverviewCurrent Diagnosis and Treatment of Gastroesophageal Reflux DiseaseAssessment of neural inhibition of the lower esophageal sphincter in cats with esophagitisPROKINETIC AGENTSComparison of Medical and Surgical Therapy for Complicated Gastroesophageal Reflux Disease in VeteransMaintenance therapy: Is there still a place for antireflux surgery?Prospective evaluation of omeprazole treatment in reflux oesophagitis refractory to H2-receptor antagonistsComparison of a Dimethicone/Antacid (Asilone Gel) with an Alginate/Antacid (Gaviscon Liquid) in the Management of Reflux OesophagitisEffects of cisapride on parameters of oesophageal motility and on the prolonged intraoesophageal pH test in infants with gastro-oesophageal reflux disease.Reflux EsophagitisPulmonary Manifestations of Gastrointestinal DiseaseProkinetic Agents: A Key in the Future of GastroenterologyReview article: a role for gastrointestinal prokinetic agents in the treatment of reflux oesophagitis?Sensitivity of the esophageal mucosa to pH in gastroesophageal reflux diseaseSensitivity of the Esophageal Mucosa to pH in Gastroesophageal Reflux DiseaseEsophageal Chest Pain: Current Controversies in Pathogenesis, Diagnosis, and TherapyJoel E. Richter, MD, Laurence A. Bradley, PhD, Donald O. Castell, MDHeartburnEfficacy of Sucralfate in Refractory Reflux Esophagitis:Results of a Pilot StudyCombined therapy with cisapride and cimetidine in severe reflux oesophagitis: a double blind controlled trial.Chest pain associated with esophageal diseaseReflux EsophagitisGastroesophageal Reflux: Experience of Gastrointestinal and Surgical UnitsSucralfate versus Placebo in Reflux Esophagitis: A Double-Blind Multicenter Study4 The medical therapy of reflux oesophagitisOnce-Daily Administration of Famotidine for Reflux EsophagitisTreatment of Severe Reflux EsophagitisJOEL E. RICHTER, M.D. 1 January 1986Volume 104, Issue 1Page: 112-114KeywordsForecastingGastroesophageal reflux disease Issue Published: 1 January 1986 PDF DownloadLoading ...