THE SERUM PROTEINS IN RHEUMATOID ARTHRITIS
Authors: A D WALLIS
Journal: Annals of Internal Medicine (1950)

Article1 January 1950THE SERUM PROTEINS IN RHEUMATOID ARTHRITISALLAN D. WALLIS, M.D.ALLAN D. WALLIS, M.D.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-32-1-63 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptOne of the unexplained aspects of rheumatoid (atrophic) arthritis is its effect on the proteins of the blood. Using sulfate fractionation, Davis1 found that severe rheumatoid arthritis is regularly accompanied by a decrease in the plasma albumin and an increase in the plasma globulin, particularly the euglobulin fraction. The albumin-globulin (A-G) ratio was correspondingly lowered, as follows:normal range 1.81-2.35 (average 2.12)rheumatoid arthritis:severe 0.69-1.07 (average 0.90)moderate 1.11-1.83 (average 1.47)"arrested" 1.24-1.95 (average 1.52)Significant changes were not found in the total protein. A similar trend was observed by Scull, Bach and Pemberton,2 using serum.Subsequently, several groups...Bibliography1. Davis JS: Protein studies in atrophic (rheumatoid) and hypertrophic arthritis, J. Lab. and Clin. Med. 21: 478-489, 1936. Google Scholar2. ScullBachPemberton CWTFR: Serum proteins in rheumatoid disease, Ann. Int. Med. 12: 1463-1472, 1939. LinkGoogle Scholar3. Tiselius A: Electrophoretic analysis and the constitution of native fluids, Harvey Lectures 35: 37-70, 1939-40. Google Scholar4. van der ScheerWyckoff JRW: An electrophoretic study of tetanus antitoxin sera, Proc. Soc. Exper. Biol. and Med. 43: 427-428, 1940. CrossrefGoogle Scholar5. van der ScheerWyckoffClarke JRWFH: The electrophoretic analysis of several hyperimmune horse sera, J. Immunol. 39: 65-71, 1940. Google Scholar6. van der ScheerWyckoffClarke JRWFH: The electrophoretic analysis of tetanal antitoxic horse sera, J. Immunol. 40: 173-177, 1941. Google Scholar7. 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PETERSDORF, M.D.Aetiology and pathogenesis of rheumatoid arthritisFILTER PAPER ELECTROPHORESIS OF SERUM PROTEINS IN CLINICAL PRACTICERHEUMATISM AND ARTHRITIS REVIEW OF AMERICAN AND ENGLISH LITERATURE OF RECENT YEARS (TENTH RHEUMATISM REVIEW)* Part IIWILLIAM D. ROBINSON, M.D., F.A.C.P., EDWARD W. BOLAND, M.D., F.A.C.P., JOSEPH J. BUNIM, M.D., F.A.C.P., DARRELL C. CRAIN, M.D., F.A.C.P., EPHRAIM P. ENGLEMAN, M.D., F.A.C.P., WALLACE GRAHAM, M.D., F.R.C.P. (C), L. MAXWELL LOCKIE, M.D., F.A.C.P., MAX M. MONTGOMERY, M.D., F.A.C.P., CHARLES RAGAN, M.D., F.A.C.P., MARIAN W. ROPES, M.D., F.A.C.P., EDWARD F. ROSENBERG, M.D., F.A.C.P., CHARLEY J. SMYTH, M.D.Weitere Untesuchungen �ber die Dysprotein�mie beim Rheumatismus verus und verwandten KrankheitenDie Elektrophorese bei inneren KrankheitenDie Elektrophorese in der PädiatrieThe serum proteins in rheumatic diseasesPlasma and Serum Proteins in Chronic Rheumatic DiseasesA Theory of the Pathogenesis of Rheumatoid ArthritisSOME OBSERVATIONS ON THE EOSINOPHILH. J. L. M. 1 January 1950Volume 32, Issue 1Page: 63-71KeywordsBloodBlood plasmaChemical analysisChemical fractionationGlobulinsProteinsRheumatoid arthritisSerum proteinsSulfatesSurgery ePublished: 1 December 2008 Issue Published: 1 January 1950 PDF downloadLoading ...