tbuckley/cabot-search huggingface dataset:
Patient satisfaction with post-operative telephone calls after Mohs micrographic surgery: a New Zealand and U.K. experience
Authors: J. Hafiji, P. Salmon, W. Hussain
Journal: British Journal of Dermatology (2012)

Background Mohs micrographic surgery (MMS) is regarded as the gold standard for treating nonmelanoma skin cancers of the head and neck. Surgical interventions can generate anxiety for patients and efforts to minimize this may enhance their experience. Objectives To assess the perceived patient benefits of post‐operative telephone follow‐up (TFU) calls after MMS. Methods A prospective, controlled, questionnaire‐based assessment of patient satisfaction with TFU calls in patients undergoing MMS was conducted in two centres (New Zealand and U.K.) over a 4‐month period from June to September 2011. All individuals in the study group were telephoned on the evening of their surgery by the operating surgeon. Questionnaires were completed by all patients at the time of suture removal. Results The median Likert score on a 10‐point scale relating to patients’ perception of the TFU service was higher in the study group compared with the control group (10 vs. 9), with no correlation to closure type of the surgical defect. Overall patient satisfaction with the TFU service was high (94% New Zealand; 96% U.K.), and this was independent of the patient’s place of residence. There was no age or sex difference in the minority who did not find the TFU call helpful. The majority of patients felt the best time to call was the night of the surgery (89% New Zealand; 94% U.K.). All patients who had undergone MMS previously found the TFU call just as useful as the first time. The majority of patients (94% New Zealand; 96% U.K.) did not need to call the doctor post‐surgery, although 7% of patients in the control group rang the surgeon with issues that could have been readily dealt with by the TFU service. Comparatively, more patients from the U.K. felt their satisfaction would have been the same with a nurse‐led TFU call service compared with New Zealand (94% vs. 66%). A significant proportion of those who preferred to be called by the doctor underwent cutaneous flap closures. Patients felt that other specialities that perform surgical procedures under local anaesthetic should adopt a TFU service post‐surgery. Conclusions TFU calls post‐MMS are a cost‐effective, time‐efficient way of achieving high levels of patient satisfaction.
Natural variation in light sensitivity of Arabidopsis
Authors: Julin N. Maloof, Justin O. Borevitz, Tsegaye Dabi, Jason Lutes, Ramlah B. Nehring, Joanna L. Redfern, Gabriel T. Trainer, Jeanne M. Wilson, Tadao Asami, Charles C. Berry, Detlef Weigel, Joanne Chory
Journal: Nature Genetics (2001)
Israel's occupation of Palestinian territories has damaged health, charity report says
Authors: O. Dyer
Journal: BMJ (2003)

Israel's occupation of Gaza and the West Bank has damaged the health of the civilian population, a report from the charity Medecins du Monde has said. Since the beginning of the second Intifada in September 2000, the charity has noted a “general deterioration in the state of health of patients [seen] in medical centres, related to the limit of access to health care.”

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A clinic in Nablus after a search by Israeli

Credit: MEDECINS DU MONDE

The report places the …

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613. Display of Different Protein Scaffolds on Envelope Glycoprotein of Avian Leukosis Virus
Authors: Alexa Bieler, Alexandra Bernshausen, Sybille Staerk, Anka Grosso, Bernd Gaensbacher, Per Sonne Holm
Journal: Molecular Therapy (2004)

Malignant gliomas, the most common primary brain tumors, are refractory to current treatment and patients' median survival time is about 1 year. Malignant glioblastomas are often displaying a radiation-resistant and respectively a multidrug-resistant phenotype. The y-box protein YB-1 is highly abundant in gliomas and involved in determination of drug resistance.
A workshop that has changed my practice: Selling cheese---a beginner's guide
Authors: S. A Evans
Journal: BMJ (1998)

The application of counter current immunoelectrophoresis to the detection of Haemophilus influenzae capsular antigen in sputum is described. The method, technically simple, provided results within 30 minutes. H. influenzae capsular antigen was detected in 12% of patients and in 54.8% of the H. influenzae strains isolated. The test was not impaired by prior antibiotic therapy.
A Research Agenda for Malaria Eradication: Basic Science and Enabling Technologies
Journal: PLoS Medicine (2011)

Today's malaria control efforts are limited by our incomplete understanding of the biology of Plasmodium and of the complex relationships between human populations and the multiple species of mosquito and parasite. Research priorities include the development of in vitro culture systems for the complete life cycle of P. falciparum and P. vivax and the development of an appropriate liver culture system to study hepatic stages. In addition, genetic technologies for the manipulation of Plasmodium need to be improved, the entire parasite metabolome needs to be characterized to identify new druggable targets, and improved information systems for monitoring the changes in epidemiology, pathology, and host-parasite-vector interactions as a result of intensified control need to be established to bridge the gap between bench, preclinical, clinical, and population-based sciences.
Abstract 13967: Clinical Epidemiology of Heart Failure With Preserved Ejection Fraction (HFpEF) in Comparatively Young Patients (< 65 years of age)
Authors: Samuel W Joffe, Michael Zacharias, Elizabeth Konadu, Michael S Kiernan, Darleen Lessard, Jorge Yarzebski, Robert J Goldberg
Journal: Circulation (2013)

Background: HFpEF accounts for approximately half of all cases of HF. While HFpEF is primarily a disease of old age, its prevalence among younger patients is increasing, yet there is a paucity of d...
Cutaneous presentation of nasal/nasal type T/NK cell lymphoma: clinicopathological findings of four cases
Authors: None Miyamoto, None Yoshino, None Takehisa, None Hagari, None Mihara
Journal: British Journal of Dermatology (1998)

Epstein-Barr virus (EBV)-associated T/natural killer (NK) cell lymphoma mainly shows nasal lesions, and has recently been shown to be associated with cutaneous T-cell lymphoma (CTCL). The detailed features of CTCL nasal metastasis have yet to be elucidated. We report clinicopathological findings for four cases of cutaneous T/NK cell lymphoma with metastasis to the nose. The four patients presented progressive involvement of nasal lesions of CTCL, an aggressive course and poor outcome. Their pathological and immunohistological findings were consistent with peripheral T/NK cell neoplasm and, in three of four cases, EBER-1 were apparently detected in lymphoma cells by in situ hybridization, and two of four cases were also positive for TIA-1. The polymerase chain reaction (PCR) results showed the identical band from the skin and nasal lesions of the two patients. We also reviewed the cases of similar clinical course and attempted to elucidate clinical, pathological, immunological and genotypic features. The 10 reported cutaneous T/NK cell lymphomas with nasal metastasis revealed a poor prognosis (nine of 10 died at 3-108 months). Six cases of nine showed a positive reaction to EBV, and six cases revealed T-cell receptor beta or -gamma rearrangement. These findings suggest that most cutaneous T/NK cell lymphoma with nasal metastasis are similar to nasal T-cell lymphoma associated with EBV infection. This type of cutaneous T/NK cell lymphoma likely to involve nasal lesions and skin cases seemed to have a poor prognosis.
Abstract 73: Lipid Mediators as Novel Biomarkers and Surrogate Indicators of Neurologic Recovery after Cardiac Arrest in a Hypothermic Swine Model
Authors: Christopher J. White, Victor L. Marcheselli, Andreas Janata, Alexandra Schratter, Wolfgang Weihs, Keywan Bayegan, Richard V. Milani, Nicolas G. Bazan
Journal: Circulation (2006)

Background: Prognostic tools to predict neurologic outcome are essential so that relevant care can be given to patients awakening from coma, and futile intensive care be avoided in patients with severe hypoxic ischemic encephalopathy. There is a need for biomarkers as surrogate indicators of ischemic brain injury or recovery. We studied lipid mediators (Neuroprotectin D1, (NPD1), DHA, PGE-2, and PGD-2) that would reflect the status of anti-inflammatory signaling in endothelial cells and/or brain parenchyma. Methods: Swine who had return of spontaneous circulation (ROSC) after cardiac arrest, with CPR, and up to 3 shocks were randomized to receive 20 hours of hypothermia with Life Recovery Systems (LRS) Thermosuita,,¢ at 34A° C (n=6) or as normothermic controls (n = 8). Serial blood samples were obtained at intervals up to 48 hrs. Results: The time required to reach the target cooling temperature was 9.0 min. Normal neurologic function was regained in all 6 hypothermic animals but in only 1 of 8 normothe...
Rebound anxiety in anxious patients after abrupt withdrawal of benzodiazepine treatment
Authors: R Fontaine, G Chouinard, L Annable
Journal: American Journal of Psychiatry (1984)

In this double-blind, placebo-controlled study of 4 weeks of benzodiazepine treatment followed by 3 weeks of abrupt or gradual drug withdrawal, 16 patients whose benzodiazepine was withdrawn abruptly were worse (p less than .05) than 13 who had received placebo in terms of change in mean anxiety scores from the pretreatment level. The scores of seven patients (44%) whose benzodiazepine was withdrawn abruptly increased 10% or more on both the Hamilton Rating Scale for Anxiety and the Self Rating Symptom Scale. There were no cases of rebound anxiety in 14 patients whose benzodiazepine was withdrawn gradually; fewer cases of rebound anxiety were seen with a benzodiazepine that had a long half-life.
Abstract P360: Hypertension Treatment Rates And Health Worker Density: An Analysis Of Worldwide Data
Authors: Rajesh Vedanthan, Mondira Ray, Valentin Fuster, Ellen Magenheim
Journal: Circulation (2014)

Introduction: Hypertension is the leading global risk for mortality and its prevalence is increasing in many low- and middle-income countries. Hypertension treatment rates are low worldwide, potentially in part due to insufficient human resources. However, the relationship between health worker density and hypertension treatment rates is unknown. Objective: To conduct an econometric analysis of the relationship between health worker density and hypertension treatment rates worldwide. Methods: Hypertension treatment rates were collected from published reports between 1980 and 2010. Data on health worker (physician and nurse) density were obtained from the World Health Organization (WHO). Data for potential confounding variables--per capita gross domestic product, hospital bed density, burden of infectious diseases, land area and urban population--were obtained from WHO and World Bank databases. Potential interaction by per capita gross domestic product was evaluated. Multivariable logistic-logarithmic regression analysis was performed using Stata. Results: Full data were available from 146 countries spanning all World Bank income classification categories. Health worker density was significantly associated with hypertension treatment rate in the unadjusted model (beta = 0.23; p &lt; 0.005). In the fully adjusted model, the association remained positive but was not statistically significant (beta = 0.30; p = 0.078) (Figure). Hypertension treatment rates were more strongly related to physician than nurse density (beta = 0.21 vs 0.08; p = 0.10 vs 0.49). Conclusion: Hypertension treatment rates across the world appear to be related to health worker density, although the relationship does not achieve strict statistical significance. Our results suggest that a 10% increase in health worker density is associated with a 2-3% increase in hypertension treatment rate. Given the global burden of hypertension and other chronic diseases, WHO guidelines for health workforce staffing may need to be reconsidered.
In Memoriam: Monroe E. Wall (1916–2002)
Authors: Mansukh C. Wani
Journal: Cancer Research (2002)

Monroe E. Wall, Chief Scientist at the Research Triangle Institute in Research Triangle Park, NC, died on July 6, 2002 at age 85. Together, we discovered the anticancer compound Taxol, which helped revolutionize modern cancer treatment. By isolating and elucidating the structure of this novel,
Chronic Pulmonary Infections in Childhood
Authors: Allen K. Krause
Journal: Annals of Internal Medicine (1931)

Article1 May 1931Chronic Pulmonary Infections in ChildhoodALLEN K. KRAUSEALLEN K. KRAUSESearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-4-11-1424 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptFor years our withers have been wrung by an unremitting chorus of concern over the sad, yes, the desperate case of the child with tuberculosis. One with a fair memory need not ask for particulars. Most of us here whom age is beginning to beckon set out to practice medicine with the fixed idea that a tuberculous baby must die, a preconception that, to my knowledge, bore fruit in a pediatrician of repute preparing an aspiring and unsuspecting mother for the inevitable by solemnly, yet as gently as possible, informing her that her flourishing young heir of six months, off... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Tucson, Arizona*From the Desert Sanatorium and Institute of Research, Tucson, Arizona.†Presented at a meeting of the Southwestern Pediatric Society, Los Angeles, California, December 15, 1930. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byTuberculosis in children 1 May 1931Volume 4, Issue 11Page: 1424-1440KeywordsMemoryPediatric infectionsPulmonary diseases ePublished: 1 December 2008 Issue Published: 1 May 1931 PDF downloadLoading ...
Introduction to Physiological Chemistry.
Authors: Meyer Bodansky
Journal: JAMA (1930)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Association of Chronic Kidney Disease With the Spectrum of Ankle Brachial Index
Authors: Joachim H. Ix, Ronit Katz, Ian H. De Boer, Brian R. Kestenbaum, Matthew A. Allison, David S. Siscovick, Anne B. Newman, Mark J. Sarnak, Michael G. Shlipak, Michael H. Criqui
Journal: Journal of the American College of Cardiology (2009)
Randomised Trial of Two Intravenous Schedules of the Liposomal Topoisomerase I Inhibitor, OSI-211, in Women With Relapsed Epithelial Ovarian Cancer. A Trial of the National Cancer Institute of Canada Clinical Trials Group
Authors: GG Dark, AH Calvert, R Grimshaw, C Poole, K Swenerton, S Kaye, R Coleman, G Jayson, T Le, S Ellard, M Trudeau, P Vasey, M Hamilton, T Cameron, E Barrett, W Walsh, L McIntosh, E Eisenhauer
Journal: Journal of Clinical Oncology (2005)
Epigenetic inactivation of the hSPRY2 gene in human prostate cancer
Authors: Arthur B. McKie, David A. Douglas, Julia Graham, Sharon Olijslagers, Craig N. Robson, Hing Y. Leung
Journal: Cancer Research (2004)

Proc Amer Assoc Cancer Res, Volume 45, 2004

4179 

Fibroblast growth factors (FGFs) and their receptors are key modulators of normal prostate proliferation with their over-expression associated with aggressive prostate cancer (CaP) and less favourable survival outcome. Recent studies have highlighted the importance of negative regulation of growth factor signalling systems through mechanisms involving the ubiquitin ligase c-Cbl and inhibitory proteins such as Sprouty. Initial RT-PCR analysis confirmed human Spry2 expression in prostate cancer cell lines at low to moderate levels in LNCaP and DU145 with high levels in PC3 cells. Interestingly, invasive subclones of LNCaP and PC-3 (namely LN3, PC-3M, PC-3MPRO4 and PC-3MLN4) expressed Spry2 at significantly lower levels than their corresponding parental cells. Quantitative RT-PCR was carried out on a cohort of resected CaP and BPH specimens: high grade (poorly differentiated) CaP expressed Spry2 at significantly lower levels than both BPH and well differentiated tumours (p= 0.004). We therefore hypothesise that the observed reduced Spry2 expression is related to the process of prostate carcinogenesis. The hSPRY2 gene maps to the long arm of chromosome 13, the second most common site of genetic loss in CaP from multiple CGH and LOH studies. We therefore set out to investigate whether hSPRY2 is a likely target for gene inactivation. The existence of a large CpG island from -700 nt upstream of the putative transcription start through the first exon into the intronic sequence led us to investigate the possibility of epigenetic inactivation at this locus. Treatment of LNCaP and PC-3M cells with 5-aza-2’-deoxycytidine (Aza dCR) led to an increase in Spry2 expression from barely detectable levels to moderate levels. Using a combination of methylation specific PCR, COBRA and direct sequencing, we have observed extensive hypermethylation of the CpG island in 85% of moderate to high grade PCa cases (n=21). Seven control cases of benign prostatic hyperplasia (BPH) were however unmethylated. Furthermore, selected CaP tumors with reduced Spry2 expression in quantitative RT-PCR were shown to be extensively hypermethylated and control BPH specimens with high levels of Spry2 expression were unmethylated. Extensive SSCP analysis yielded little evidence of mutation within the hSPRY2 gene, however 42% Loss of Heterozygosity (LOH) was observed with close flanking markers (D13S1255 and D13S1277) extending distally to D13S266. In summary, we present evidence of hypermethylation as a key mechanism for the suppression of Spry2 expression, with concomitant hemizygosity at this locus providing a potential key event in promoting deregulated growth factor induced signalling in prostate carcinogenesis
Manual of Intensive Care Medicine.
Authors: Richard S. Irwin, James M. Rippe.
Journal: Annals of Internal Medicine (1984)

Completely rewritten and updated for the Fourth Edition, this Spiral[registered] Manual remains the leading quick-reference guide to both medical and surgical intensive care. The essential principles, protocols, and techniques from Irwin and Rippe's Intensive Care Medicine, Fifth Edition have been distilled into a portable, practical manual that is ideal for rapid bedside consultation. The user-friendly format features numerous tables, illustrations, and annotated references. This edition has completely revamped sections on cardiovascular problems and coronary care, surgical problems, shock and trauma, endocrine problems, and hematology, plus expanded coverage of gastroesophageal balloon tamponade, aspiration of joints, hepatic dysfunction, and noninvasive mechanical ventilation.
Susceptibility of Seven Inbred Strains and the F&lt;sub&gt;1&lt;/sub&gt; Hybrids to Estrogen-Induced Testicular Tumors and Occurrence of Spontaneous Testicular Tumors in Strain BALB/c Mice
Authors: Howard B. Andervont, Michael B. Shimkin, Harry Y. Canter
Journal: JNCI Journal of the National Cancer Institute (1960)

Journal Article Susceptibility of Seven Inbred Strains and the F1 Hybrids to Estrogen-Induced Testicular Tumors and Occurrence of Spontaneous Testicular Tumors in Strain BALB/c Mice Get access Howard B. Andervont, Howard B. Andervont Laboratory of Biology, and Biometry and Epidemiology Branch, National Cancer Institute,2Bethesda, Maryland Search for other works by this author on: Oxford Academic PubMed Google Scholar Michael B. Shimkin, Michael B. Shimkin Laboratory of Biology, and Biometry and Epidemiology Branch, National Cancer Institute,2Bethesda, Maryland Search for other works by this author on: Oxford Academic PubMed Google Scholar Harry Y. Canter Harry Y. Canter Laboratory of Biology, and Biometry and Epidemiology Branch, National Cancer Institute,2Bethesda, Maryland Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 25, Issue 5, November 1960, Pages 1069–1081, https://doi.org/10.1093/jnci/25.5.1069 Published: 01 November 1960 Article history Received: 09 May 1960 Published: 01 November 1960
UK seeks to prevent 50 000 winter deaths from “fuel poverty”
Authors: Judy Jones
Journal: BMJ (2001)

The UK government has launched a 10 year strategy to prevent deaths among old and vulnerable people as a result of fuel poverty. Some studies have suggested that as many as 50 000 people die annually because they cannot afford to heat their homes properly.

About 4.5 million people across the United Kingdom are expected to benefit from the £1.5bn ($2.25bn) a year programme. The main target is to ensure that by 2010 no vulnerable household—older people, families with young children, people with disabilities, and people with long term illness—need to risk ill health, or worse, because of a cold home.

In England five areas will be designated “warm zones” …
Inflammatory Markers and Incident Heart Failure Risk in Older Adults
Authors: Andreas Kalogeropoulos, Vasiliki Georgiopoulou, Bruce M. Psaty, Nicolas Rodondi, Andrew L. Smith, David G. Harrison, Yongmei Liu, Udo Hoffmann, Douglas C. Bauer, Anne B. Newman, Stephen B. Kritchevsky, Tamara B. Harris, Javed Butler
Journal: Journal of the American College of Cardiology (2010)
The Clinical Spectrum of Necrotizing Autoimmune Myopathy
Authors: Matthew N. Meriggioli
Journal: JAMA Neurology (2015)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Neurology HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Neurology journal