MAJOR BLEEDING RESULTING FROM A SINGLE DOSE OF DICUMAROL
Authors: John J. Butler, David F. James
Journal: Annals of Internal Medicine (1950)

Case Reports1 April 1950MAJOR BLEEDING RESULTING FROM A SINGLE DOSE OF DICUMAROLJOHN J. BUTLER, M.D., DAVID F. JAMES, M.D.JOHN J. BUTLER, M.D., DAVID F. JAMES, M.D.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-32-4-731 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptMultiple doses of Dicumarol have frequently been reported to cause major bleeding episodes. On the other hand, it has been often emphasized1, 2 that large single doses of Dicumarol given to normal animals and human beings cause marked prolongation of the prothrombin time but do not cause bleeding.Herein is reported a case of major bleeding following a single dose of 300 mg. of Dicumarol in a patient with poor kidney function.CASE REPORTA 31 year old colored female was admitted to Grady Hospital on April 22, 1948, with the chief complaint of abdominal pain. Her illness had begun...Bibliography1. OvermanStahmannSullivanHeubnerCampbellLink RSMAWRCFHHKP: Studies on the hemorrhagic sweet clover disease. VII. The effect of 3,3-methylenebis (4-hydroxycoumarin) on the prothrombin time of the plasma of various animals, J. Biol. Chem. 142: 941-955, 1942. CrossrefGoogle Scholar2. Link KP: The Harvey Lecture, 1943-44, p. 162. Google Scholar3. DavidsonMcDonald CSH: The effect of vitamin K1 oxide on hypoprothrombinemia induced by Dicumarol, New England J. Med. 229: 353-355, 1943. CrossrefGoogle Scholar4. JamesBennettScheinbergButler DFILPJJ: Clinical studies on Dicumarol hypoprothrombinemia and vitamin K preparations. I. The superiority of vitamin K1 oxide over menadione bisulfite and synkavite in reversing Dicumarol hypoprothrombinemia, Arch. Int. Med. 83: 632-652, 1949. CrossrefGoogle Scholar5. ShumackerAbramsonLamper HBDIHH: The use of anticoagulants in the surgery of aneurysms and arteriovenous fistulas with particular reference to Dicumarol, Surgery 22: 910-918, 1947. MedlineGoogle Scholar6. StatsBullowa DJG: Effect of a single dose of 3,3′-methylenebis (4-hydroxycoumarin) upon blood coagulation in humans, Proc. Soc. Exper. Biol. and Med. 50: 66-70, 1942. CrossrefGoogle Scholar7. WrightPrandoni ISA: The dicumarin 3,3′ methylenebis (4-hydroxycoumarin), its pharmacologic and therapeutic action in man, J. A. M. A. 120: 1015-1021, 1943. CrossrefGoogle Scholar8. RichardsSteggerda RKFR: Dicumarol 3,3′ methylenebis (4-hydroxycoumarin) in rats with impaired kidney function, Proc. Soc. Exper. Biol. and Med. 52: 358-360, 1943. CrossrefGoogle Scholar9. BollmanPreston JLFW: The effects of experimental administration of dicumarin, 3,3′ methylenebis (4-hydroxycoumarin), J. A. M. A. 52: 1021-1025, 1943. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Emory University Georgia*Received for publication June 25, 1949.From the Department of Medicine, Emory University Medical School, Emory University Hospital, Atlanta, Georgia. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byIntracerebral Hemorrhagic Expansion Occurs in Patients Using Non–Vitamin K Antagonist Oral Anticoagulants Comparable with Patients Using WarfarinMajor bleeding in outpatients treated with warfarin: incidence and prediction by factors known at the start of outpatient therapyEditorialDie thromboembolische KrankheitIntravenous emulsified vitamin K1 in the treatment of coumarin-induced hypoprothrombinemia 1 April 1950Volume 32, Issue 4Page: 731-735KeywordsAbdominal painHemorrhageHospital medicineKidneysProthrombin time Issue Published: 1 April 1950 PDF downloadLoading ...