tbuckley/cabot-search huggingface dataset:
In Vivo Distribution of Adoptively Transferred Indium- 111- Labeled Tumor Infiltrating Lymphocytes and Peripheral Blood Lymphocytes in Patients With Metastatic Melanoma
Authors: K. D. Griffith, E. J. Read, J. A. Carrasquillo, C. S. Carter, J. C. Yang, B. Fisher, P. Aebersold, B. S. Packard, M. Y. Yu, S. A. Rosenberg
Journal: JNCI Journal of the National Cancer Institute (1989)

Journal Article In Vivo Distribution of Adoptively Transferred Indium- 111- Labeled Tumor Infiltrating Lymphocytes and Peripheral Blood Lymphocytes in Patients With Metastatic Melanoma Get access Kean D. Griffith, Kean D. Griffith Surgery Branch, National Cancer Institute, National Institutes of HealthBethesda, MD Search for other works by this author on: Oxford Academic PubMed Google Scholar Elizabeth J. Read, Elizabeth J. Read Department of Transfusion Medicine, National Cancer Institute, National Institutes of HealthBethesda, MD Search for other works by this author on: Oxford Academic PubMed Google Scholar Jorge A. Carrasquillo, Jorge A. Carrasquillo Department of Nuclear Medicine, National Cancer Institute, National Institutes of HealthBethesda, MD Search for other works by this author on: Oxford Academic PubMed Google Scholar Charles S. Carter, Charles S. Carter Department of Transfusion Medicine, National Cancer Institute, National Institutes of HealthBethesda, MD Search for other works by this author on: Oxford Academic PubMed Google Scholar James C. Yang, James C. Yang * Surgery Branch, National Cancer Institute, National Institutes of HealthBethesda, MD *Dr. James C. Yang, Bldg. 10, Rm, 2B37, National Institutes of Health, Bethesda, MD 20892. Search for other works by this author on: Oxford Academic PubMed Google Scholar Beth Fisher, Beth Fisher Surgery Branch, National Cancer Institute, National Institutes of HealthBethesda, MD Search for other works by this author on: Oxford Academic PubMed Google Scholar Paul Aebersold, Paul Aebersold Surgery Branch, National Cancer Institute, National Institutes of HealthBethesda, MD Search for other works by this author on: Oxford Academic PubMed Google Scholar Beverly S. Packard, Beverly S. Packard Surgery Branch, National Cancer Institute, National Institutes of HealthBethesda, MD Search for other works by this author on: Oxford Academic PubMed Google Scholar Monica Y. Yu, Monica Y. Yu Department of Transfusion Medicine, National Cancer Institute, National Institutes of HealthBethesda, MD Search for other works by this author on: Oxford Academic PubMed Google Scholar Steven A. Rosenberg Steven A. Rosenberg Surgery Branch, National Cancer Institute, National Institutes of HealthBethesda, MD Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 81, Issue 22, 15 November 1989, Pages 1709–1717, https://doi.org/10.1093/jnci/81.22.1709 Published: 15 November 1989 Article history Received: 12 July 1989 Revision received: 08 August 1989 Accepted: 12 September 1989 Published: 15 November 1989
17Inhibition of the ubiquitin ligase atrogin-1 impairs chmp2b turnover, blocks autophagy flux and causes cardiomyopathy
Authors: T Zaglia, G Milan, A Ruhs, M Franzoso, E Bertaggia, N Pianca, D Catalucci, M Kruger, M Mongillo, M Sandri
Journal: Cardiovascular Research (2014)

Purpose: Control of cardiomyocyte (CM) proteostasis operated by the ubiquitin/proteasome (UPS) and autophagy/lysosome systems is fundamental for heart adaptation to both physiologic and pathologic stresses. Reduced efficiency of either UPS or autophagy/lysosome system occurs during ageing and has been associated to cardiomyopathies. Atrogin-1 is a muscle specific ubiquitin ligase, targeting for degradation signalling proteins involved in cardiac hypertrophy. However, the role of Atrogin-1 in CM biology and its involvement in the molecular mechanism of cardiac dysfunction, are largely unexplored. Methods: We analyzed hearts from Atrogin-1 knock-out (KO) mice from 6 mo. onwards until death, and compared it to that of age- and sex-matched controls. Functional, immunofluorescence and electron microscopy analyses were performed. Markers of ER/SR stress and autophagy/lysosome systems were investigated by RTqPCR and WB. In vivo pulsed SILAC proteomics and bioinformatics, Co-IP, in vitro assays and in vivo viral silencing were performed to identify novel targets of Atrogin-1. Results: By using in vivo and in vitro assays we identified a novel target of Atrogin-1, the ESCRTIII protein CHMP2B, that plays a fundamental role in autophagy. Failure to degrade CHMP2B in Atrogin-1 KO mice caused autophagy impairment, accumulation of intracellular protein aggregates, activation of the unfolded protein response and subsequent CM apoptosis, all of which increased progressively during ageing. The alterations in cellular proteostasis resulted in cardiomyopathy with a restrictive pattern, characterized by myocardial remodelling with interstitial fibrosis, diastolic dysfunction (Edt, KO: 20.7±2.7 vs WT: 27.8±5.7, in msec), arrhythmias and secondary LA and ventricular remodelling, as well as CM hypertrophy (CM area, KO: 289.34±2.23 vs WT: 236.77±1.64, in μm2). Aged Atrogin-1 KO mice had reduced tolerance to treadmill exercise compared to controls, and shortened life span (KO: 17±1 vs WT: 24±1.2, in mo.). In vivo reduction of CHMP2B protein level in the KO mice restored normal autophagy and protected CMs from cell death resulting from CHMP2B proteotoxicity. Conclusions: Our data highlight the importance of regulated proteolysis in the heart and show that the loss of Atrogin-1 per se is sufficient to cause cardiac damage, which evolves into cardiomyopathy when protein quality control becomes less efficient, as occurring in aging. Such cardiomyopathy represents a novel model of proteotoxic myocardial remodelling and will be useful to determine the mechanism of impaired proteostasis to CM damage.
Association of features of atopy and diagnostic parameters in hymenoptera venom allergy*
Authors: B. Przybilla, J. Ring, B. Grieshammer
Journal: Allergy (1991)

In a total of 525 patients with hypersensitivity reactions to hymenoptera stings diagnostic parameters of hymenoptera venom (HV) allergy (severity of reactions, skin test threshold and RAST for bee and vespid venoms) were investigated for their relationship to the following indicators of atopy: positive history of atopic diseases, elevated (≤ 100 kU/1) total scrum IgE and positive prick test reactions to common inhalant allergens (CIA) (grass pollen, cat epithelium, house dust mite). There was a conclusive history of atopic disease in 25%, a total serum IgE ≥ 100 kU/1 in 48%, and at least one positive reaction to CIA in 53%. Total IgE ≥ 100 kU/l correlated with a higher frequency of RAST classes ≥ 2 ( P &lt; 0.01) and with less severe reactions to hymenoptera stings ( P &lt; 0.05). In the presence of at least one positive reaction to CIA, there were more frequently skin test thresholds ≤ 10 μg/ml ( P &lt; 0.05) and RAST classes ≥ 2 ( P &lt; 0.01) for HV than in CIA prick test negative individuals. There was no significant relationship between the other pairs of parameters evaluated. Thus, reactivity to HV in diagnostic tests is increased in the presence of certain indicators of atopy. This has to be considered in the interpretation of skin test and RAST results obtained with HV.
Maternal Smoking during Pregnancy and the Prevalence of Autism Spectrum Disorders, Using Data from the Autism and Developmental Disabilities Monitoring Network
Authors: Amy E. Kalkbrenner, Joe M. Braun, Maureen S. Durkin, Matthew J. Maenner, Christopher Cunniff, Li-Ching Lee, Sydney Pettygrove, Joyce S. Nicholas, Julie L. Daniels
Journal: Environmental Health Perspectives (2012)

Reported associations between gestational tobacco exposure and autism spectrum disorders (ASDs) have been inconsistent.We estimated the association between maternal smoking during pregnancy and ASDs among children 8 years of age.This population-based case-cohort study included 633,989 children, identified using publicly available birth certificate data, born in 1992, 1994, 1996, and 1998 from parts of 11 U.S. states subsequently under ASD surveillance. Of these children, 3,315 were identified as having an ASD by the active, records-based surveillance of the Autism and Developmental Disabilities Monitoring Network. We estimated prevalence ratios (PRs) of maternal smoking from birth certificate report and ASDs using logistic regression, adjusting for maternal education, race/ethnicity, marital status, and maternal age; separately examining higher- and lower-functioning case subgroups; and correcting for assumed under-ascertainment of autism by level of maternal education.About 13% of the source population and 11% of children with an ASD had a report of maternal smoking in pregnancy: adjusted PR (95% confidence interval) of 0.90 (0.80, 1.01). The association for the case subgroup autistic disorder (1,310 cases) was similar: 0.88 (0.72, 1.08), whereas that for ASD not otherwise specified (ASD-NOS) (375 cases) was positive, albeit including the null: 1.26 (0.91, 1.75). Unadjusted associations corrected for assumed under-ascertainment were 1.06 (0.98, 1.14) for all ASDs, 1.12 (0.97, 1.30) for autistic disorder, and 1.63 (1.30, 2.04) for ASD-NOS.After accounting for the potential of under-ascertainment bias, we found a null association between maternal smoking in pregnancy and ASDs, generally. The possibility of an association with a higher-functioning ASD subgroup was suggested, and warrants further study.
A critical assessment of the mechanism by which hyperoxia attenuates exercise-induced asthma.
Authors: A D Resnick, E C Deal, R H Ingram, E R McFadden
Journal: Journal of Clinical Investigation (1979)

Recent data demonstrate that the magnitude of the heat loss that occurs from the respiratory tract during exercise correlates with the degree of post-exertional obstruction that develops in asthmatics. Respiratory heat loss relates directly to the minute ventilation and heat capacity of the inspired gas and inversely to its water content and temperature. Because it has been shown that inhaling 100% oxygen during exercise blunts the obstructive response, we wondered if this effect could be accounted for by differing values of heat exchange with air and oxygen breathing. To examine this question, we studied 10 asthmatics by measuring multiple aspects of pulmonary mechanics before and after four bouts of exhausting leg work during which the subjects inhaled either air or oxygen conditioned to provide widely differing thermal burdens on their airways. Under all inspired gas conditions, oxygen breathing produced significantly less obstruction than air. Minute ventilation was also significantly less with oxygen as was the total heat lost. As the latter fell, so did the magnitude of the postexercise obstruction. When the differences in ventilation and respiratory heat loss between air and oxygen were eliminated by eucapnic hyperventilation, the differences in the obstructive responses also disappeared. Thus, the effects of hyperoxia on exercise-induced asthma can be accounteed for solely by alterations in heat exchange.
Distinct roles for protease-activated receptors 1 and 2 in vasomotor modulation in rat superior mesenteric artery
Authors: Atsufumi Kawabata, Satoko Kubo, Yumiko Nakaya, Tsuyoshi Ishiki, Ryotaro Kuroda, Fumiko Sekiguchi, Naoyuki Kawao, Hiroyuki Nishikawa
Journal: Cardiovascular Research (2004)

Protease-activated receptors (PARs) 1 and 2 are expressed in various blood vessels including rat aorta, modulating vascular tone. We investigated the roles of PAR-1 and PAR-2 in vasomotor modulation in rat superior mesenteric artery.Effects of the PAR-2-activating peptide Ser-Leu-Ile-Gly-Arg-Leu-amide (SLIGRL-amide) and the PAR-1-activating peptide Thr-Phe-Leu-Leu-Arg-amide (TFLLR-amide) on isometric tension were examined in isolated rat superior mesenteric artery or aorta. Both SLIGRL-amide and TFLLR-amide caused relaxation in the precontracted rat aortic rings. The latter peptide, but not the former, produced contraction in the resting rings. NG-nitro-L-arginine methyl ester (L-NAME), but not apamin/charybdotoxin known to block the endothelium-derived hyperpolarizing factor (EDHF) pathway, abolished the relaxation and facilitated the contraction. In the precontracted rat superior mesenteric artery, SLIGRL-amide, but not TFLLR-amide, elicited endothelium-dependent relaxation, which was only partially inhibited by L-NAME with and without indomethacin. The residual relaxation was abolished by apamin/charybdotoxin. Carbenoxolone, a gap junction inhibitor, significantly attenuated the SLIGRL-amide-evoked, EDHF-dependent relaxation, although neither 17-octadecynoic acid, a P450 epoxygenase inhibitor, nor catalase, a hydrogen peroxide scavenger, revealed inhibitory effects. The residual response resistant to carbenoxolone was unaffected by ouabain/BaCl2. In the resting artery, TFLLR-amide, but not SLIGRL-amide, produced only slight contraction, which was dramatically facilitated by combination of L-NAME and apamin/charybdotoxin or by removal of the endothelium.Our data suggest that, in rat superior mesenteric artery, endothelial PAR-2, upon activation, causes relaxation via both NO and EDHF pathways, and that activation of muscular PAR-1 exhibits potential contractile activity that is largely masked by NO and EDHFs pathways triggered by endothelial PAR-1. Gap junctions might be involved in the EDHF mechanisms in this artery.
Do tidal expiratory flow patterns reflect lung mechanics in infants?
Authors: P C Seddon, G M Davis, A L Coates
Journal: American Journal of Respiratory and Critical Care Medicine (1996)

It has been suggested that during tidal breathing, the time to maximal expiratory flow, as a proportion of total expiratory time (Tme/TE), can be used as an index of airways obstruction. However, the relationship of Tme/TE to lung mechanics in infants is unclear. We examined this relationship in 42 premature infants (21 intubated and 21 not intubated) by comparing direct measures of pulmonary mechanics (lung resistance, dynamic lung compliance, and lung impedance) with Tme/TE measured over the same sample of tidal breathing. Tme/TE was positively correlated with lung compliance, expressed as a percent of the predicted value, in both intubated (r = 0.69, p < 0.005) and nonintubated (r = 0.64, p < 0.02) infants. There was no significant association between Tme/TE and lung resistance, expressed as a percent of the predicted value, in intubated (r = 0.32) and nonintubated (r = 0.23) infants. Tme/TE also showed, in nonintubated infants, a positive association with lung impedance, expressed as a percent of the predicted value, on the basis of the predictive values for compliance and resistance at the infant's unique respiratory rate, but this was significant only because of the influence of compliance on Tme/TE. These findings suggest that, in infants, the relationship between pulmonary mechanics and Tme/TE is complex, with Tme/TE being influenced by the elastic rather than the flow-resistive properties of the lungs.
British public supports legal abortion for all
Authors: J. Wise
Journal: BMJ (1997)

Public support for abortion on demand has increased substantially over the past 20 years, according to a survey of 1888 adults across Britain.

View this table:

Percentage of respondents who approved or disapproved of abortion under different circumstances in 1997



The MORI survey carried out for the Birth Control Trust and the British Pregnancy Advisory Service …
Staging After Myocardial Infarction
Authors: RICHARD K. MAUTNER
Journal: Annals of Internal Medicine (1981)

Letters and Corrections1 October 1981Staging After Myocardial InfarctionRICHARD K. MAUTNER, M.D.RICHARD K. MAUTNER, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-95-4-514 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: The recent reports on early treadmill testing after myocardial infarction by Schwartz and associates (1) and Fuller and colleagues (2) are timely and of great interest. The prognastic value of a positive test is of major importance in the subsequent decision making on the need for coronary arteriography and for coronary artery bypass surgery. Unfortunately, however, of the 52 patients evaluated who had a negative treadmill test, 22 (44%) had multivessel coronary arterial disease. Similarly we have recently reported data from 13 select patients who had early symptom-limited treadmill testing and coronary arteriography after infarction and found...References1. SCHWARTZTURNERSHEFFIELD KJL. Limited exercise testing soon after myocardial infarction: correlation with early coronary and left ventricular angiography. Ann Intern Med. 1981;94:727-34. LinkGoogle Scholar2. FULLERRAIZNERVERANI CAM. Early post myocardial infarction treadmill stress testing: an accurate predictor of multivessel coronary disease and subsequent cardiac events. Ann Intern Med. 1981;94:734-9. LinkGoogle Scholar3. MAUTNERADAMSPHILLIPS RAJ. Early treadmill testing and coronary arteriography after myocardial infarction. South Med J. 1981;74:183-6. CrossrefMedlineGoogle Scholar4. MAUTNER R. Routine coronary arteriography in asymptomatic postinfarction patients. Chest. 1981;79:126-7. Letter. CrossrefMedlineGoogle Scholar5. TURNERROGERSMANTLERACKLEYRUSSELL JWJCR. Coronary angiography soon after myocardial infarction. Chest. 1979;77:58-64. CrossrefGoogle Scholar6. ROGERSSMITHOBERMAN WLA. Surgical vs nonsurgical management of patients after myocardial infarction. Circulation. 1980;62(Suppl I): I-67-74. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: New Orleans Veterans Administration Medical Center New Orleans, LA 70112 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byExercise Tests After Myocardial InfarctionASHOK K. AGARWAL, M.D. 1 October 1981Volume 95, Issue 4Page: 514-514KeywordsAngiographyCoronary arteriesDecision makingInfarctionMyocardial infarctionResearch designStable coronary artery diseaseSurgery Issue Published: 1 October 1981 PDF downloadLoading ...
Temporal trends in prognostic markers of HIV-1 virulence and transmissibility: an observational cohort study
Authors: Nikos Pantazis, Kholoud Porter, Dominique Costagliola, Andrea De Luca, Jade Ghosn, Marguerite Guiguet, Anne M Johnson, Anthony D Kelleher, Charles Morrison, Rodolphe Thiebaut, Linda Wittkop, Giota Touloumi
Journal: The Lancet HIV (2014)
Protocol-Based Computer Reminders, the Quality of Care and the Non-Perfectability of Man
Authors: Clement J. McDonald
Journal: New England Journal of Medicine (1976)

To determine whether clinical errors can be reduced by prospective computer suggestions about the management of simple clinical events, I studied the responses of nine physicians to computer suggestions generated by 390 protocols in a controlled crossover design. These protocols dealt primarily with conditions managed (e.g., elevated blood pressure) or caused (e.g., liver toxicity) by drugs. Physicians responded to 51 per cent of 327 events when given, and 22 per cent of 385 events when not given computer suggestions. Neither level of postgraduate training (first-year postgraduate or third-year post-graduate) nor the order in which physicians served as study and control subjects had statistically significant overall effect on the results. It appears that the prospective reminders do reduce errors, and that many of these errors are probably due to man's limitations as a data processor rather than to correctable human deficiencies.
Predictors of Early- and Late-Onset Supraventricular Tachyarrhythmias After Fontan Operation
Authors: Kritvikrom Durongpisitkul, Co-burn J. Porter, Frank Cetta, Kenneth P. Offord, Jeffrey M. Slezak, Francisco J. Puga, Hartzell V. Schaff, Gordon K. Danielson, David J. Driscoll
Journal: Circulation (1998)

Background —The objectives of our study were to determine the frequency of supraventricular tachyarrhythmias (SVTAs) among modifications of the Fontan operation and identify risk factors for developing SVTA. Methods and Results —The population consisted of all patients who had any modification of the Fontan operation at the Mayo Clinic between 1985 and 1993. Clinically significant SVTAs were those requiring initiation or change of antiarrhythmic treatment, and they were divided into early SVTAs (&lt;30 days after the operation) and late SVTAs (≥30 days after the operation). Clinical histories were reviewed, and health status questionnaires were sent. Four hundred ninety-nine patients had various modifications of the Fontan operation. Frequency of early SVTA was 15%. Risk factors identified by multivariate analysis for early SVTA were AV valve regurgitation, abnormal AV valve, and preoperative SVTA. Frequency of late SVTA was 6% by 1 year, 12% by 3 years, and 17% by 5 years. Risk factors for late SVTA were age at operation (&lt;3 or ≥10 years) and systemic AV valve replacement. By univariate and multivariate analysis, the type of Fontan operation was not a significant risk factor for late SVTA when all 6 modifications were considered. However, when we analyzed the frequency of late SVTA for the 2 recently used modifications, we found a lower frequency of late SVTA in patients with atriopulmonary connection with lateral tunnel compared with those with total cavopulmonary connection. Conclusions —Postoperative SVTA continues to be a significant problem. Risk factors for SVTA are AV valve regurgitation, abnormal AV valve, preoperative SVTA, and age at operation. Frequency of SVTA does not appear to be related to type of Fontan procedure except for slightly lower frequency in patients with atriopulmonary connection with lateral tunnel compared with those with total cavopulmonary connection.
Cooperation Between Government and Industry in Combating a Perceived Emerging Pandemic
Authors: Maurice R. Hilleman
Journal: JAMA (1996)

Influenza virus is the paradigm<sup>1</sup>for dealing with emerging and reemerging infections throughout the world. The disease can be prevented by vaccination if the vaccine composition is immunologically relevant to the virus causing the epidemic or pandemic. A swine influenza outbreak occurred at Fort Dix, NJ, in early February 1976<sup>2-4</sup>(Table 1). Type A influenza virus of swine zoonotic origin occasionally infects humans, but for the first time recorded, there was significant person-to-person spread in the outbreak. The unexpected spread was likely related to stress and the housing of military recruits in the confined space of barracks during their basic training. The question was whether this episode might predict a worldwide pandemic of influenza, like that of 1918-1919, in which its three waves killed 600 000 persons in the United States and was estimated to have cost approximately $100 billion. The 1918-1919 pandemic was caused by a human
Re: Annette Kuhn, Caroline Eggeman, Fiona Burkhard and Michael D. Mueller. Correction of Erosion after Suburethral Sling Insertion for Stress Incontinence: Results and Related Sexual Function. Eur Urol 2009;56:371–7
Authors: Maurizio Serati, Stefano Uccella, Stefano Salvatore
Journal: European Urology (2008)
The Collaterals of the Coronary Arteries in Normal and Pathologic Hearts
Authors: GIORGIO BAROLDI, ORESTE MANTERO, GIUSEPPE SCOMAZZONI
Journal: Circulation Research (1956)

The collateral vessels of normal and pathologic hearts were studied by making plastic casts of the coronary vessels. The normal heart possesses conspicuous coronary anastomoses. The localization, the development and to a certain extent, the incidence was studied. The maximum increase in collateral vessels was observed in cases of coronary narrowing; a less pronounced increase was found in conditions of chronic hypoxemia.