Allopurinol in the Treatment of Gout
Authors: R. Wayne Rundles, Earl N. Metz, H. R. Silberman
Journal: Annals of Internal Medicine (1966)

Article1 February 1966Allopurinol in the Treatment of GoutR. WAYNE RUNDLES, M.D., F.A.C.P., EARL N. METZ, M.D., H. R. SILBERMAN, M.D.R. WAYNE RUNDLES, M.D., F.A.C.P.Search for more papers by this author, EARL N. METZ, M.D.Search for more papers by this author, H. R. SILBERMAN, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-64-2-229 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptAllopurinol, 4-hydroxypyrazolo (3,4-d) pyrimidine (4-HPP),*recently introduced as a new type of agent useful in the treatment of gout, developed from studies undertaken to increase the therapeutic efficacy of 6-mercaptopurine (6-MP) and related thiopurines in leukemia. Since the biologically active form of 6-MP is its ribonucleotide (Figure 1) (1-4), all reactions leading to the removal of 6-MP from this anabolic pathway would decrease its activity. Studies on the metabolic fate of 6-MP in the mouse (5) and the human (6-9) have shown that the major catabolic pathway is oxidative. About 25 to 30% of the total dose of 6-MP is...References1. WAYPARKS JLRE: Enzymatic synthesis of 5′-phosphate nucleotides of purine analogues. J. Biol. Chem. 231: 467, 1958. CrossrefMedlineGoogle Scholar2. SALSERHUTCHINSONBALIS JSDJME: Studies on the mechanism of action of 6mercaptopurine in cell-free preparations. J. Biol. Chem. 235: 429, 1960. CrossrefMedlineGoogle Scholar3. PATERSON AR: Thiopurine nucleotide synthesis in a 6-MP-resistant subline of the Ehrlich ascites carcinoma and growth inhibition by certain antimetabolites. Canad. J. Biochem. 38: 1129, 1960. MedlineGoogle Scholar4. BROCKMAN RW: A mechanism of resistance to 6-mercaptopurine: metabolism of hypoxanthine and 6-mercaptopurine by sensitive and resistant neoplasms. Cancer Res. 20: 643, 1960. MedlineGoogle Scholar5. ELIONBIEBERHITCHINGS GBSGH: The fate of 6-mercaptopurine in mice. Ann. N. 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To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Durham, North CarolinaFrom the Hematology Laboratory, Duke Hospital, and the Department of Medicine, Duke University School of Medicine, Durham, N. C.This study was undertaken as an exploratory trial for the Southeastern Cancer Chemotherapy Cooperative Study Group. The work was supported in part by grant CY-3177 from the National Cancer Institute, Cancer Chemotherapy National Service Center, Bethesda, Md., and grant MO1-FR-30 from the National Institutes of Health supporting the Duke Medical Center Clinical Research Unit.Dr. Metz was a Trainee in Cancer Chemotherapy and Hematology supported by grant T4 CA 5042 from the National Cancer Institute.Requests for reprints should be addressed to R. Wayne Rundles, M.D., Department of Medicine, Duke University Medical Center, Durham, N. C. 27706.*Zyloprim®, Burroughs Wellcome 56-158. 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IRVIN, M.D.Allopurinol hypersensitivityDauertherapieUric Acid Metabolism in ManHypouricemiaThe influence of allopurinol on renal function in goutZur Beeinflussung der Purin- und Pyrimidinsynthese durch AllopurinolThe Leukemias and LymphomasLOCAL IMMUNITY AND ULCERATIVE COLITISALLOPURINOL AND BONE-MARROW DEPRESSIONEffects of Allopurinol and Oxipurinol on Pyrimidine Biosynthesis in ManContributo Allo Studio Della Litolisi Vescicale in Varie Condizioni SperimentaliMetabolic studies of purine metabolism in the pig during the oral administration of guanine and allopurinolEFFECTS OF CARBON, NITROGEN, AND ALLOPURINOL ON THE ABUNDANCE OF PARTICIPATE INCLUSIONS IN A MARINE DINOFLAGELLATE12The Spectrum of Myeloproliferative DisordersAplastic agranulocytosis after allopurinol therapyLa Terapia Medica Della Calcolosi Urica UrinariaHazard of Combining Allopurinol and ThiopurineTHE MANAGEMENT OF GOUTGranulomatous Hepatitis in a Patient Receiving AllopurinolALLOPURINOL AND OXIPURINOL: ALTERATION OF PURINE AND PYRIMIDINE METABOLISM IN CELL CULTUREL'Allopurinolo in Urologia Nota 2 A : La Calcolosi UricaThe effect of allopurinol on the excretion of oxypurines by the chickThe myeloproliferative disordersHyperuricemia Complicating Acute LeukemiaThe Dias Rounds Drug Information Analysis ServiceDisorder of purine metabolism due to partial deficiency of hypoxanthine-guanine phosphoribosyltransferaseVasculitis with allopurinol therapyNucleotide Biosynthesis from Preformed Purines in Mammalian Cells: Regulatory Mechanisms and Biological SignificancePhysiologic and Biochemical Basis for the Treatment of Gout and HyperuricemiaUric Acid Renal Lithiasis: Management by AllopurinolHypoxanthine-Guanine Phosphoribosyltransferase Deficiency in GoutWILLIAM N. 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SEEGMILLER, M.D.L'Allopurinolo in Urologia(*): Nota 1aUric acid nephrolithiasisRenal clearance of oxipurinol, the chief metabolite of allopurinolETIOLOGY AND TREATMENT OF GOUT-MODERN CONCEPTSChronic allopurinol administration and iron storage in miceSulla Prevenzione Delle Calcolosi Da Acido Urico Con AllopurinoloAn Enzymatic Basis for Variation in Response to AllopurinolKompetitive Enzymmechanismen bei der Therapie von Hämoblastosen mit AntimetabolitenHERPES SIMPLEX IN PEPTIC ULCERATION?ALLOPURINOL AND IRON STORAGEACADEMIC RADIOLOGY AND RECRUITMENTALLOPURINOL AND IRON METABOLISMTHE USE OF THE XANTHINE OXIDASE INHIBITOR, ALLOPURINOL, IN THE CONTROL OF HYPERURICAEMIA, GOUT AND URIC ACID CALCULIStudies of uric acid metabolism in glycogen storage disease associated with gouty arthritisAllopurinol Control of Hyperuricosuria: A New Concept in the Prevention of Uric Acid StonesASPIRIN AND PLATELET STICKINESSALLOPURINOL AND IRON METABOLISMRecent Advances in the Rheumatic DiseasesEPHRAIM P. ENGLEMAN, M.D., F.A.C.P., MARTIN A. SHEARN, M.D., F.A.C.P.Use of allopurinol in preventing hyperuricemia in leukemia and lymphomaMetabolic Changes Associated with Recovery from Vitamin B12 DeficiencyEFFECT OF A XANTHINE-OXIDASE INHIBITOR (ALLOPURINOL) ON RADIOIRON ABSORPTION IN MANTHE KIDNEY IN HEPATIC DISEASE AND IN GOUT: CLINICAL AND PATHOLOGIC ASPECTS 1 February 1966Volume 64, Issue 2Page: 229-258KeywordsAllopurinolArthritisCancer chemotherapyExcretionGoutHematology and oncologyHospital medicineResearch laboratoriesToxicityUric acid ePublished: 1 December 2008 Issue Published: 1 February 1966 Copyright & PermissionsCopyright ©, 1966, by The American College of PhysiciansPDF downloadLoading ...