Pyridoxine and Amiodarone-Induced Photosensitivity
Authors: JOHN P. MULROW
Journal: Annals of Internal Medicine (1985)

Brief Reports1 July 1985Pyridoxine and Amiodarone-Induced PhotosensitivityJOHN P. MULROW, M.D., CYNTHIA D. MULROW, M.D., M.Sc., WILLIAM J. McKENNA, M.D.JOHN P. MULROW, M.D.Search for more papers by this author, CYNTHIA D. MULROW, M.D., M.Sc.Search for more papers by this author, WILLIAM J. McKENNA, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-103-1-68 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptAmiodarone is an effective antiarrhythmic agent (1-5) but its use is often limited by unwanted effects (6). Photosensitivity develops in as many as 75% of white patients and is severe in more than 30% (7). No known clinical features identify susceptible patients, and recommended therapies such as sunscreens have not proved effective.Pyridoxine was recently reported to suppress amiodarone-induced photosensitivity in three patients (8), but in-vitro studies (9) suggest pyridoxine enhances rather than suppresses amiodarone phototoxicity. Potential adverse effects indicate the need for thorough evaluation. We did a randomized, double-blind, placebo-controlled trial to evaluate the efficacy of pyridoxine in preventing...References1. ZIPESPRYSTOWSKYHEGER DEJ. Amiodarone: electrophysiologic actions, pharmacokinetics and clinical effects. J Am Coll Cardiol. 1984;3:1059-71. CrossrefMedlineGoogle Scholar2. HAFFAJEELOVEALPERTASDOURIANSLOAN CJJGK. Efficacy and safety of long-term amiodarone in treatment of cardiac arrhythmias: dosage experience. Am Heart J. 1983;106:935-43. CrossrefMedlineGoogle Scholar3. MARCUSFONTAINEFRANKGROSGOGEAT FGRY. Clinical pharmacology and therapeutic applications of the antiarrhythmic agent amiodarone. Am Heart J 1981;101:480-93. CrossrefMedlineGoogle Scholar4. MCKENNAROWLANDKRIKLER WED. Amiodarone: the experience of the past decade. Br Med J [Clin Res]. 1983;287:1654-6. CrossrefMedlineGoogle Scholar5. ROTMENSCHBELHASSENSWANSON HBB. Steady-state serum amiodarone concentrations: relationships with antiarrhythmic efficacy and toxicity. Ann Intern Med. 1984;101:462-8. LinkGoogle Scholar6. HARRISMCKENNAROWLANDKRIKLER LWED. Side effects and possible contraindications of amiodarone use. Am Heart J. 1983;106(4 pt 2):916-23. CrossrefMedlineGoogle Scholar7. CHALMERSMUSTONSRINIVASBENNETT RHVD. High incidence of amiodarone-induced photosensitivity in north-west England. Br Med J [Clin Res]. 1982;285:341. CrossrefMedlineGoogle Scholar8. KAUFMANN G. Pyridoxine against amiodarone-induced photosensitivity [Letter]. Lancet. 1984;1:51-2. CrossrefMedlineGoogle Scholar9. GUERCIOLINIDEL FAVEROCANNISTRARO RAS. Amiodarone-induced photosensitivity and pyridoxine [Letter]. Lancet 1984;1:962. CrossrefMedlineGoogle Scholar10. SCHWARTZFLAMANTLELLOUCH DRJ. Clinical Trials. London: Academic Press; 1980:245. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Hammersmith Hospital London England PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byRelief of the photosensitivity of erythropoietic protoporphyria by pyridoxineA general overview of amiodarone toxicity: Its prevention, detection, and managementInteractions of Vitamin B6 (Pyridoxine) and XenobioticsAmiodaroneCardiac glycosides and drugs used in dysrhythmiasSafety of pyridoxine — A review of human and animal studies 1 July 1985Volume 103, Issue 1Page: 68-69KeywordsAttentionBlood plasmaCardiovascular diseasesDrugsPatientsPyridoxine Issue Published: 1 July 1985 PDF downloadLoading ...