tbuckley/cabot-search huggingface dataset:
Falsely Positive Wassermann and Kahn Reactions in Infective Hepatitis
Authors: J. H. Waelsch
Journal: BMJ (1946)

From the L.C.C. Group Laboratory, Archway Hospital) This case and its laboratory findings are reported to show that, so far as careful investigation can indicate, falsely positive Wassermann and Kahn reactions may occur during the course of infective hepatitis and disappear during recovery.The case was one of a large series met with while working on a routine scheme for investigating jaundice and liver enlargement without jaundice which included serological tests.The other cases in the series and their laboratory investigations will be dealt with in a further communication.Case RecordThe patient, an unmarried female aged 21, suffered from nausea, heartburn, and vomiting for six days before admission, when she began to be jaundiced.Her urine was dark and she was con- stipated.She had not felt well for the previous four weeks and did not go to work for three weeks before admission.Four months
277 The use of bovine polyethylene glycol-modified adenosine deaminase (PEG-ADA) in correcting the immunodeficiency in a child with severe combined immunodeficiency-adenosine deaminase deficiency (SCID-ADA[ − ])
Authors: AD Kobayashi, RH Kobayashi, RI Schiff, J Claassen, MS Hershfield
Journal: Journal of Allergy and Clinical Immunology (1988)
European Medicines Agency is attacked over proposal to allow technology assessment bodies to sell advice to drug industry
Authors: J. Wise
Journal: BMJ (2014)

The European Medicines Agency has been criticised over its plan to allow health technology assessment bodies to provide confidential advice to drug companies in exchange for fees. A coalition of medicine advocates denounced the practice, which they said was a clear conflict of interest.

The agency has provided scientific advice to the drug industry for a fee since 2005. A “basic fee” in 2014 for an initial request for scientific advice on safety and clinical development is €83 600 (£66 000; $113 170). In 2010 a pilot project started that allowed health technology assessment bodies to also give advice to drug companies when they were at an early stage of developing a drug. And in May this year the agency released for public consultation draft guidance to extend this parallel scientific advice.1 The consultation process ended on 14 July.

Health Action International Europe, the International Society of Drug Bulletins, the Medicines in Europe Forum, and the …
Terfenadine-Ketoconazole Interaction
Authors: Peter K. Honig, Dale C. Wortham, Kaveh Zamani, Dale P. Conner, James C. Mullin, Louis R. Cantilena
Journal: JAMA (1993)

To examine prospectively the effects of ketoconazole on the pharmacokinetics and electrocardiographic repolarization pharmacodynamics (corrected QT intervals) of terfenadine in men and women.Prospective cohort study with each subject serving as his or her own control.Outpatient cardiology clinic and inpatient telemetry unit for monitoring period.Six healthy volunteers (four men and two women, aged 24 to 35 years) not taking any prescription or over-the-counter medications.After achieving a steady state while taking terfenadine (60 mg every 12 hours for 7 days), daily concomitant oral ketoconazole (200 mg every 12 hours) was added to the subjects' regimen. Pharmacokinetic profiles were obtained while subjects were taking terfenadine alone and after the addition of ketoconazole. Electrocardiograms were obtained at baseline, after 1 week of taking terfenadine alone, and at the time of the second pharmacokinetic profile after the addition of ketoconazole to the regimen.Terfenadine and its acid metabolite serum concentrations and corrected QT intervals.All subjects had detectable levels of unmetabolized terfenadine after the addition of ketoconazole, which was associated with QT prolongation. Only two of the six subjects could complete the entire course of ketoconazole coadministration. Four subjects received a shortened duration of ketoconazole therapy because of significant electrocardiographic repolarization abnormalities. There was a significant change in the area under the curve of the acid metabolite of terfenadine after the addition of ketoconazole administration.Ketoconazole alters the metabolism of terfenadine in normal men and women and results in the accumulation of unmetabolized parent drug, which is associated with significant prolongation of the corrected QT interval. This drug combination should be avoided.
Authors reject interpretation linking autism and MMR vaccine
Authors: Susan Mayor
Journal: BMJ (2004)

Ten of the 13 authors of the research paper that first raised the possibility of a link between the measles, mumps, and rubella (MMR) vaccine and autism ( Lancet 1998;351:637-41), resulting in a major fall in the number of children being vaccinated in the United Kingdom, “retracted” this interpretation of their findings in a statement published last week ( Lancet 2004;363:750).

They said, “The main thrust of the paper was the first description of an unexpected intestinal lesion in the children reported … We wish to make it clear that in this paper no causal link was established between MMR vaccine and autism as the data were insufficient. However, the possibility of such a link was raised and consequent events have had major implications for public health. In view of this, we consider now is the appropriate time that we should together formally retract the interpretation placed upon these findings in the paper.”

Two of the original authors, Andrew Wakefield and Peter Harvey, did not sign the retraction, and the Lancet said that it hoped to publish their response soon. Another of the authors could not be contacted.

The study investigated 12 children who were referred …
Who Shall Enter?
Authors: Walter S. Wiggins
Journal: JAMA (1965)

<h3>To the Editor:—</h3> In response to the editorial of Nov 16, 1964 (<i>JAMA</i><b>190</b>:677) regarding the supply of applicants, may I say that there are some of us in medical education who look upon your statement that "good applicants will still be turned away" as a declaration of defeat. At least to date. Every American boy who is willing and able should be allowed his medical training. No attempt to limit anyone's professional ambitions on the basis of geographic or economic factors should be permitted. Under the present conditions we are denying our Hippocratic oath when we teach only 100 of the 170 applicants. Our obligation is not to the "public welfare" but to the entirety of humanity on this earth. The future of American medicine lies not in the present expediency of importing physicians but in the training of every able American for his role in the world.
ROLE OF EXERCISE HEMODYNAMICS IN UNMASKING OF DIASTOLIC DYSFUNCTION AMONG PATIENTS WITH PULMONARY HYPERTENSION
Authors: Elad Maor, Yoni Grossman, Ronen Balmor, Michael Segel, Paul Fefer, Sagit Ben-Zekry, Yonatan Buber, Elio DiSegni, Issahar Ben-Dov, Amit Segev
Journal: Journal of the American College of Cardiology (2014)
The in vivo performance of ferrocenyl tamoxifen lipid nanocapsules in xenografted triple negative breast cancer
Authors: Anne-Laure Lainé, Eric Adriaenssens, Anne Vessières, Gérard Jaouen, Cyril Corbet, Emilie Desruelles, Pascal Pigeon, Robert-Alain Toillon, Catherine Passirani
Journal: Biomaterials (2013)
Research suppressed for seven years by drug company
Authors: J. Wise
Journal: BMJ (1997)

A drug company suppressed research which showed that generic thyroid drugs were as effective as its own branded product for almost seven years, says the Journal of the American Medical Association .

A randomised four way crossover trial concluded that two brand name and two generic forms of thyroxine sodium (levothyroxine) were bioequivalent and interchangeable without loss of therapeutic efficacy in most patients for the treatment of hypothyroidism ( JAMA 1997;277:1205-18). The two brand name products were Synthroid–the most commonly used brand in the United States–and Levoxine (now renamed Levoxyl)–a newer, cheaper product similar in price to generic forms.

Thyroxine sodium is widely prescribed in the United States as the drug of choice for thyroid replacement treatment. The Food and Drug Administration (FDA) does not recognise thyroxine sodium products as bioequivalent, and generic substitution is not recommended. The authors of the study estimate that using generic or less expensive brand name products in the United States could save $356m (£223m) a year.



The research community is …
Isolated hypercalciuria with mutation in CLCN5: Relevance to idiopathic hypercalciuria
Authors: Steven J. Scheinman, Jeremy P.D. Cox, Sarah E. Lloyd, Simon H.S. Pearce, Page V. Salenger, Richard R. Hoopes, David A. Bushinsky, Oliver Wrong, John R. Asplin, Craig B. Langman, Anthony G.W. Norden, Rajesh V. Thakker
Journal: Kidney International (2000)
Biomarkers of liver cell death
Authors: Akiko Eguchi, Alexander Wree, Ariel E Feldstein
Journal: Journal of Hepatology (2014)

<h2>Summary</h2> Hepatocyte cell death during liver injury was classically viewed to occur by either programmed (apoptosis), or accidental, uncontrolled cell death (necrosis). Growing evidence from our increasing understanding of the biochemical and molecular mechanisms involved in cell demise has provided an expanding view of various modes of cell death that can be triggered during both acute and chronic liver damage such as necroptosis, pyroptosis, and autophagic cell death. The complexity of non-invasively assessing the predominant mode of cell death during a specific liver insult in either experimental <i>in vivo</i> models or in humans is highlighted by the fact that in many instances there is significant crosstalk and overlap between the different cell death pathways. Nevertheless, the realization that during cell demise triggered by a specific mode of cell death certain intracellular molecules such as proteins, newly generated protein fragments, or MicroRNAs are released from hepatocytes into the extracellular space and may appear in circulation have spurred a significant interest in the development of non-invasive markers to monitor liver cell death. This review focuses on some of the most promising markers, and their potential role in assessing the presence and severity of liver damage in humans.
Young Christian Girl
Authors: M. Therese Southgate
Journal: JAMA (2007)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Bronchorrhoea--separation of mucus and serum components in sol and gel phases.
Authors: M T Lopez-Vidriero, I Das, L Reid
Journal: Thorax (1979)

Bronchorrhoea sputum separates into two phases--sol and gel--at low speed centrifugation (5000 g), although higher speed (160 000 g) is required to obtain complete separation. Markers of mucus glycoprotein and serum transudate have been estimated in sputum, sol, and gel in five cases of bronchorrhoea associated with chronic bronchitis, asthma, or alveolar cell carcinoma. In all samples markers of both mucus glycoprotein and serum component were present in each phase. The concentration of serum markers was similar in both phases suggesting that it is to the serum that mucus glycoprotein is added. Since the volume of sol is greater, the total of serum components is higher in the sol than in the gel although, in total, a considerable amount was present in the gel. The fucose/sulphate ratio suggests that the glycoprotein in the sol is relatively more sulphated than is that of the gel, indicating that they may represent secretion from different cell types. The pattern of separation of two serum markers, IgA and transferrin, is different from that of albumin. Whether this is because they are locally produced or because they are selectively bound to mucus glycoprotein in the gel is not clear.
New Three-Dimensional Echocardiographic System Using Digital Radiofrequency Data—Visualization and Quantitative Analysis of Aortic Valve Dynamics With High Resolution
Authors: Michael Handke, Cosima Jahnke, Gudrun Heinrichs, Jörg Schlegel, Clemens Vos, Daniel Schmitt, Christoph Bode, Annette Geibel
Journal: Circulation (2003)

Common 3D systems have only limited spatial and temporal resolution (frame rate of 25 Hz). Thin structures such as cardiac valves are not imaged exactly; rapid movement patterns cannot be precisely recorded. The objective of the present project was to achieve radiofrequency (RF) data transmission to the 3D workstation to improve image resolution.A commercially available echocardiographic system (5-MHz transesophageal echocardiography probe) with an integrated raw data interface enables transmission of RF data (up to 40 megabytes per second). A 3D data set may contain up to 3 gigabytes, so that all of the high-resolution ultrasound information of the 2D image is available. Frame rates of up to 168 Hz result in temporal resolution 6 times that of standard 3D systems. The applicability of the system and the image quality were tested in 10 patients. The structure of the aortic valve and the dynamic changes were depicted by volume rendering. The changes in the orifice areas were measured in frame-by-frame planimetry. The mean number of frames recorded per cardiac cycle was 122+/-16. The improved structural resolution enabled a detailed imaging of the morphology of the aortic cusps. The rapid systolic movement patterns were recorded with up to 51 frames. The high number of frames enabled creation of precise area-time diagrams. Thus, the individual phases of aortic valve movement (rapid opening, slow valve closing, and rapid valve closing) could be analyzed quantitatively.A 3D system based on RF data enables high-resolution imaging of cardiac movement patterns. This offers new perspectives for qualitative and quantitative analyses, especially of cardiac valves.
Cancer and the Heart
Authors: Alvin Freiman
Journal: JAMA (1987)

This book has its roots in the rapidly developing subspecialty of oncologic cardiology. Some understanding of the scope and development of this field is useful in evaluating how well the book mirrors the subspecialty and serves the needs of potential readers. Patients with cancer have all of the cardiac problems seen in the general population and, in addition develop cardiac manifestations either due to the tumor itself or resulting from therapy. Newer diagnostic procedures have significantly advanced our ability to recognize these manifestations, but it is still frequently difficult to dissect out the oncologic effects. Initially, patients with cancer and cardiac problems were handled as a relatively small fraction of general clinical cardiology, and in many locations this still represents the standard pattern of care. Certain trends have contributed to the development of this field as a subspecialty and can be expected to continue. These factors have included first, the
Legionnaires' Disease Papers
Authors: JAY P. SANFORD
Journal: Annals of Internal Medicine (1979)

Letters1 September 1979Legionnaires' Disease PapersJAY P. SANFORD, M.D.JAY P. SANFORD, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-91-3-492_1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: My summary of the International Symposium on Legionnaires' Disease, which appeared in the 22 March 1979 issue of The New England Journal of Medicine, was an invited summary and was not intended in any way to suggest attribution of scientific priority to me. There are two aspects of this article I should like to clarify.Brenner, Steigerwalt, and McDade first described the taxonomy of Legionnaires' disease bacterium, for which they proposed the nameLegionella pneumophila. This name was proposed by them at the International Symposium on Legionnaires' Disease on 13 to 15 November 1978, and their paper...Reference1. BRENNERSTEIGERWALTMCDADE DAJ. Classification of the Legionnaires' disease bacterium: Legionella pneumophila, genus novum, species nova, of the family Legionellaceae, familia nova. Ann Intern Med. 1979; 90:656-8. LinkGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: School of Medicine Uniformed Services University of the Health Sciences Bethesda, MD 20014 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 September 1979Volume 91, Issue 3Page: 492-492KeywordsLegionella pneumophilaLegionellosis Issue Published: 1 September 1979 PDF DownloadLoading ...
Type D (Delta) Hepatitis
Authors: Francesco Caredda
Journal: JAMA (1989)

To  Editor.—  Dr Hoofnagle 1 recently presented in JAMA an excellent comprehensive review of  field of type D (delta) hepatitis. However, we believe that some new findings deserve consideration. The author states that  hepatitis occurs only in patients who have HBsAg [hepatitis B surface antigen] in serum and that the clinician should consider testing for anti-HDV [antibody to hepatitis delta virus] in any patient with acute or chronic hepatitis who is tested HBsAg positive. This statement is suggested by  fact that HDV is a defective virus unable to replicate without  concomitant hepatitis B virus infection and apparently was confirmed by  negative results obtained in patients with acute HBsAg-negative hepatitis. 2 Nevertheless,  interference of HDV infection on hepatitis B virus replication is a well-known phenomenon, and a few case reports have shown that HDV can be expressed in  absence of detectable HBsAg in
The Toll-like receptor 5 ligand flagellin promotes asthma by priming allergic responses to indoor allergens
Authors: Rhonda H Wilson, Shuichiro Maruoka, Gregory S Whitehead, Julie F Foley, Gordon P Flake, Michelle L Sever, Darryl C Zeldin, Monica Kraft, Stavros Garantziotis, Hideki Nakano, Donald N Cook
Journal: Nature Medicine (2012)
Fortnightly review: Plantar fasciitis
Authors: D. Singh, J. Angel, G. Bentley, S. G Trevino
Journal: BMJ (1997)

Plantar fasciitis is the most common cause of inferior heel pain (fig 1).Its aetiology is poorly understood by many, which has led to a confusion in terminology. 1 It is said to affect patients between the ages of 8 and 80, but is most common in middle aged women and younger, predominantly male, runners. 2 The role of the doctor in the management of plantar fasciitis is to make an appropriate diagnosis and to allow enough time for the condition to run its course, with the aid of supportive measures.If treatment is begun soon after the onset of symptoms, most patients can be cured within six weeks. 3 MethodsThis article is based largely on our experience and recent concepts that have changed our management of inferior heel pain.Reviews written by experts have
Postsurgical Mortality in Manitoba and New England
Authors: Leslie L. Roos
Journal: JAMA (1990)

Per capita hospital expenditures in the United States exceed those in Canada, but little research has examined differences in outcomes. We used insurance databases to compare postsurgical mortality for 11 specific surgical procedures, both before and after adjustment for case mix, among residents of New England and Manitoba who were over 65 years of age. For low- and moderate-risk procedures, 30-day mortality rates were similar in both regions, but 6-month mortality rates were lower in Manitoba. For the two high-risk procedures, concurrent coronary bypass/valve replacement and hip fracture repair, both 30-day and 6-month mortality rates were lower in New England. Although no consistent pattern favoring New England for cardiovascular surgery was found, the increased mortality following hip fracture in Manitoba was found for all types of repair and all age groups. We conclude that for low- and moderate-risk procedures, the higher hospital expenditures in New England were not associated with lower perioperative mortality rates.
Medical Radiation Physics.
Authors: William R. Hendee
Journal: Annals of Internal Medicine (1969)

According to the preface, this is intended as a textbook for a variety of readers, including resident physicians and beginning graduate students in medical physics. The number of chapters devoted to the different topics covered will give some indication of the relative importance the author assigns to each subject. The first three chapters are concerned with the structure of matter, radioactive decay, and interactions of particulate radiations, while the next four deal with the production of x rays, x-ray circuits and generators, and the fundamental interactions of x and gamma rays with matter. Dosimetry, radiation quality, interaction of radiations with body tissues, radiation fields, and other aspects of the physics of radiotherapy are discussed in Chapters 8-16. The following four chapters cover the physics of nuclear medicine, including radiation detectors, data analysis and handling, gamma-ray spectrometry, measurement of internal radioactivity, and clinical use of radioactive nuclides. Chapters 21 through 24 deal with the physics of diagnostic radiology, including intensifying screens, conventional and television fluoroscopy, cinefluorography, stereoscopic and subtraction radiography, microradiography, computers in diagnostic radiol-
SUCCESSFUL RESULTS OF INTRACARDIAC EPINEPHRIN INJECTION
Authors: D. L. Newton
Journal: JAMA (1923)

<h3>To the Editor:</h3> —At a confinement in the Sacred Heart Hospital to which I was called in consultation by Dr. J. M. Casey, May 13, I delivered the patient of twins. The first infant fared normally, but the other did not breathe, and after ten minutes of futile effort on our part, was believed dead by a sister, who baptized it. Thereupon I injected 2 minims of 1/1000 epinephrin solution into the heart. Within fifteen seconds the infant began to breathe, and in five minutes was lying beside its brother, both twins crying lustily. When I saw them next day, they were in perfect condition.
Infliximab treatment of severe genital ulcers associated with Behçet disease
Authors: Chikatoshi Kasugai, Daisuke Watanabe, Kimihiko Mizutani, Yuko Masuda, Masahiro Zako, Tomoyuki Mukai, Yasuhiko Tamada, Yoshinari Matsumoto
Journal: Journal of the American Academy of Dermatology (2009)