tbuckley/cabot-search huggingface dataset:
Abstract 15: Increasing Compression Rate and Depth Positively Correlate with End-Tidal Carbon Dioxide During Actual CPR Performance
Authors: Kelsey Sheak, Douglas J Wiebe, Saeed Babaeizadeh, Trevor C Yuen, Dana Zive, Pamela C Owens, Dana P Edelson, Mohamud Daya, Ahamed H Idris, Benjamin S Abella, Marion Leary
Journal: Circulation (2014)

Background: Current resuscitation guidelines suggest the use of continuous capnography to monitor the effectiveness of CPR. While laboratory data support this concept, little published clinical data exist to support this recommendation. The quantitative relationship between chest compression (CC) delivery and capnographic measurement (specifically, end-tidal CO 2 (ETCO 2 )) is poorly understood, and has important implications for CPR quality assessment. Objectives: We hypothesized that increasing rate and depth of CC will be associated in real-time with increasing ETCO 2 during both in-hospital cardiac arrest (IHCA) and out-of-hospital cardiac arrest (OHCA). Methods: In a multicenter cohort study, we captured time synchronized ETCO 2 and CPR quality data from resuscitation events at 4 sites between 04/2006 [[Unable to Display Character: &amp;#8211;]] 05/2013 using CPR-sensing defibrillators (Philips Mrx-QCPR). ETCO 2 and CC rate and depth were averaged over 15-sec epochs. A linear regression analysis was performed to evaluate the relationship between CCs and ETCO 2 . Results: 29,028 epochs were processed for analysis from 583 arrest events (227 IHCA, 356 OHCA). Average age of the entire cohort was 63.7±17.1 and 213 (37%) were female. ROSC was achieved in 42% of IHCA patients and 27% of OHCA patients. CC rate range was 95-125 per min, CC depth range was 31-59 mm and ventilation rate range was 4-48 per min. CC rate was not significantly associated with ETCO 2 . CC depth was significantly associated with increased ETCO 2 . For every 10 mm increase in depth, ETCO 2 increased by 1.4 mmHg (p&lt;.001). Ventilation rate was inversely related to higher ETCO 2 . For every 10 breaths per min increase in ventilation rate, ETCO 2 was decreased by 3.0 mmHg (p&lt;.001) (see table). Conclusions: ETCO 2 during CPR directly correlated with CC depth, supporting the possible role of capnography as an approach to monitor the quality of CPR delivery. Confounding by ventilation rate may be an important consideration for future work.
Abstract 3999: Characterization of the limiting steps in the melanoma metastatic cascade
Authors: Elena Piskounova, Sean Morrison
Journal: Cancer Research (2014)

Abstract Metastasis is a complex multistep process: cancer cells have to detach from the bulk of the primary tumor, intravasate into the blood, survive anoikis and high shear forces in the blood stream while existing as single cells, extravasate into a distal site, and finally proliferate to form metastatic nodules. Each of these steps requires distinctive capabilities, which must either be intrinsic or gained. We have used a melanoma xenograft model to define three major limiting steps of the metastatic cascade: intravasation into the blood, survival in circulation/extravasation into organs, and proliferation at distal sites. In our model, melanoma tumors that have previously been shown to efficiently metastasize to distal organs when grown subcutaneously (efficient metastasizers), are also capable of overcoming each of these three bottlenecks of metastasis. On the contrary, cells that are not able to metastasize when grown subcutaneously (inefficient metastasizers), are also inefficient at each of these limiting steps. This suggests that there are significant intrinsic differences between these two classes of tumors that determine the capacity of melanoma cells to grow at each step of the metastatic cascade. To gain mechanistic insight into these differences, we have analyzed genomic mutations, gene expression and metabolomic profiles, comparing human melanomas with varying metastatic potential. Using our xenograft model we are currently investigating the role of select pathways in driving melanoma metastasis, which will ultimately lead to improved therapeutic options for patients with aggressive cancers. Citation Format: Elena Piskounova, Sean Morrison. Characterization of the limiting steps in the melanoma metastatic cascade. [abstract]. In: Proceedings of the 105th Annual Meeting of the American Association for Cancer Research; 2014 Apr 5-9; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2014;74(19 Suppl):Abstract nr 3999. doi:10.1158/1538-7445.AM2014-3999
Quantitative immunology of immune hemolytic anemia
Authors: Wendell F. Rosse
Journal: Journal of Clinical Investigation (1971)

The fixation of the first component of complement (C[unk]1) by rabbit and goat anti-IgG antibodies reacting with auto- or isoimmune antibodies attached to red cells has been investigated. Two molecules of the rabbit IgG anti-IgG were required to fix a single molecule of C[unk]1, whereas only one molecule of goat IgM anti-IgG was required. The relationship between the number of auto- or isoimmune antibody molecules attached to the red cells and the amount of C[unk]1 fixed by anti-IgG was determined by the concentration of anti-IgG. A concentration of anti-IgG was found such that the number of molecules of C[unk]1 fixed was directly proportional to the concentration of auto- or isoimmune antibody. By this method a sensitive, reproducible minimum estimate of the amount of cell-bound and serum antibody could be made.
LAT regulates γδ T cell homeostasis and differentiation
Authors: Selene Nuñez-Cruz, Enrique Aguado, Sylvie Richelme, Bruno Chetaille, Anne-Marie Mura, Mireille Richelme, Laurent Pouyet, Evelyne Jouvin-Marche, Luc Xerri, Bernard Malissen, Marie Malissen
Journal: Nature Immunology (2003)
Abstract 19124: Influence of Right Ventricular Pacing on Left Ventricular Early Diastolic Radial Lengthening and Left Atrial Conduit Function
Authors: Chikage Kihara, Kazuya Murata, Takeo Tanaka, Yasuaki Wada, Kosuke Uchida, Shinichi Okuda, Takehisa Susa, Masunori Matsuzaki
Journal: Circulation (2010)
IMMUNOLOGICAL STUDIES ON BRONCHIAL SECRETION
Authors: ERNESTO MENDES
Journal: Allergy (1975)

Rabbit anti-human bronchial secretion serum yielded, by double gel-diffusion, 5 precipitation bands with the homologous antigen. This anti-bronchial secretion serum reacting with 150 human sera (86 from patients with asthma, 17 from patients with tuberculosis, 25 from patients with other diseases and 22 normal sera) showed 1 to 3 precipitation bands in 136 sera, 4 precipitation bands in 13 sera and 5 precipitation lines in 1 serum. Precipitation bands with identity reactions were obtained when the anti-sputum sera reacted simultaneously with human sera and bronchial secretion. Identity reactions were also obtained when the anti-bronchial secretion serum absorbed with normal human sera reacted with bronchial secretion and human sera from six patients and one normal individual. The number of precipitation bands in some sera was not the same after 1 or 2 years. Based on these immunological data, the physiological concept of expectoration, according to which part of the bronchial secretion may be absorbed, was discussed.
Family Medical Care. A Report on the Family Health Maintenance Demonstration.
Authors: Marc Vincent
Journal: Annals of Internal Medicine (1963)

Dr. Silver has condensed in a book rich with facts amid details the origins, developments and results of this "Family Health Demonstration." The demonstration was set up in an attempt to find a way of giving to the patient the personal attention that he expects to receive from an individual practitioner and the higher level of technical excellence that might be possible in group practice. The author outlines the main characteristics of the present day life of the urban American family and shows what can be the role of the physician in regard to these facts.
Abstract 755: Repression of tumor survival pathways by novel and selective inhibitors of MNK1 and MNK2 kinases in glioblastoma and colorectal cancer
Authors: Tomasz Rzymski, Malgorzata Szajewska-Skuta, Adrian Zarebski, Kamil Sitarz, Lukasz Sapala, Malgorzata Zurawska, Magdalena Salwinska, Renata Windak, Ewa Trebacz, Joanna Daniel-Wojcik, Radoslaw Obuchowicz, Bozena Winnik, Ewelina Wincza, Urszula Kulesza, Katarzyna Kucwaj-Borysz, Mariusz Milik, Agnieszka Dreas, Krzysztof Brzozka
Journal: Cancer Research (2014)

Abstract Herewith, we report development of small molecule inhibitors of MNK1 and MNK2 kinases and their cellular activity. MNK1 and 2 are MAP kinase-interacting kinases that are activated by RAS and MAPK signaling pathways and are involved in regulation of translation. Both kinases phosphorylate translation initiation factor eIF4e on a conserved serine 209 residue. eIF4E can contribute to the oncogenic transformation both in vitro and in vivo and is highly expressed in various tumor types. Interestingly, mice that lack both MNK1 and MNK2 do not have any apparent phenotype, which is promising for the therapeutic window of MNK1/2 inhibitors. SEL201 is a series of small molecule inhibitors which inhibit activity of both MNK1 and MNK2 in a low nM range. Selected compounds were tested on the kinome panels and indicated MNK1 and MNK2 as primary kinase targets. SEL201 compounds caused dose dependent inhibition of phosphorylation of eIF4e at Ser209 in various cancer cell lines at concentrations &amp;lt;100nM, which were lower when compared with other reported MNK1/2 inhibitors such as Cercosporamid and CGP57380. Consistently, potent inhibition of eIF4e Ser209 was observed also in vivo after oral administration of the inhibitors in xenograft models. High potency, selectivity and favorable ADME/PK profile indicates that SEL201 inhibitors would be useful tools in probing molecular consequences of eIF4e Ser209 inhibition in cancer cells alone and in combination with other inhibitors targeting PI3K/mTOR or RAS/MEK pathway. SEL201 in vitro and in vivo activities on viability and metastasis will be presented in cellular and in vivo models of colorectal cancer and glioblastoma. SEL201 series is further developed as a promising anticancer therapy with potentially wide therapeutic window. Citation Format: Tomasz Rzymski, Malgorzata Szajewska-Skuta, Adrian Zarebski, Kamil Sitarz, Lukasz Sapala, Malgorzata Zurawska, Magdalena Salwinska, Renata Windak, Ewa Trebacz, Joanna Daniel-Wojcik, Radoslaw Obuchowicz, Bozena Winnik, Ewelina Wincza, Urszula Kulesza, Katarzyna Kucwaj-Borysz, Mariusz Milik, Agnieszka Dreas, Krzysztof Brzozka. Repression of tumor survival pathways by novel and selective inhibitors of MNK1 and MNK2 kinases in glioblastoma and colorectal cancer. [abstract]. In: Proceedings of the 105th Annual Meeting of the American Association for Cancer Research; 2014 Apr 5-9; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2014;74(19 Suppl):Abstract nr 755. doi:10.1158/1538-7445.AM2014-755
A memorable patient: A record follow up
Authors: N C Mond
Journal: BMJ (2001)

On 5 September 1944 when I was a medical officer at the 59th British Military Hospital, then in Fano on the Adriatic coast of Italy, a nun from a small Roman Catholic hospital came to ask for help. A 16 year old girl had been rescued after spending several hours trapped in the rubble of her home in Gemmano, a small town about 20 miles away; it had been virtually destroyed by bombing. Now, after this length of time, I can't remember whether it …
Basic Human Neuroanatomy. An Introductory Atlas.
Authors: Craig Watson
Journal: Annals of Internal Medicine (1975)

its broad ligaments and their contents, and close-ups of the anal canal.To avoid increasing the size and price of the book, the radiographs and living anatomy could well be omitted.Radiographs of high quality are easily obtained nowadays, and living anatomy is much too important a subject to be treated cursorily.As it stands, the atlas will have a special appeal for teachers and for graduates who do not have access to dissected material.It should certainly be in every medical library.Students will want a copy for evening perusal in company with a textbook, if they can cope with the inevitably high cost.
Implications of Disclosing Individual Results of Clinical Research—Reply
Authors: David I. Shalowitz, Franklin G. Miller
Journal: JAMA (2006)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The Role of Interleukin-10 (IL-10) in IL-15–Mediated T-Cell Responses
Authors: Dieter Körholz, Ursula Banning, Halvard Bönig, Markus Grewe, Marion Schneider, Christine Mauz-Körholz, Anne Klein-Vehne, Jean Krutmann, Stephan Burdach
Journal: Blood (1997)
THE PATIENT AND THE PHYSICIAN
Authors: J PARKINSON
Journal: Annals of Internal Medicine (1951)

Article1 August 1951THE PATIENT AND THE PHYSICIANJOHN PARKINSON, M.D., F.R.C.P., F.A.C.P. (honorary)JOHN PARKINSON, M.D., F.R.C.P., F.A.C.P. (honorary)Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-35-2-307 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptPatients will take precedence over physicians in my address, as in natural and chronologic order they do. There would be no physicians if there were no patients, and it is evident that the two groups do not see themselves as the others see them; so it is well to recognize the difference in their outlook. It will be a personal aspect which is presented to you, and my field in medicine, though large, has been circumscribed, so that I have less claim than some to the full title of physician. That cannot be so true today, when you have generously... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: London, England*Convocation Address, Thirty-second Annual Session, American College of Physicians, St. Louis, Mo., April 11, 1951. Nextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited bySir John Parkinson (1885–1976)Once on Top, Now on Tap: American Physicians View their Relationships with Patients, 1920–1970The Psychosomatic Approach in the Practice of MedicineIatrogenic anxietyEthics and practice of placebo therapyIATROGENIC HEART DISEASE*HARRY B. WEINBERG, M.D., F.A.C.P. 1 August 1951Volume 35, Issue 2Page: 307-314 ePublished: 1 December 2008 Issue Published: 1 August 1951 Copyright & PermissionsCopyright, 1951, by The American College of PhysiciansPDF downloadLoading ...
Abstract #5682: Beta4 integrin promotes osteosarcoma metastasis and interacts with ezrin
Authors: Xiaolin Wan, Su Young Kim, Arnulfo Mendoza, Joseph Briggs, Choh Yeung, Hua Zhang, Crystal Mackall, Wan-Ju Li, Rocky Tuan, Andrea Deyrup, Chand Khanna, Lee Helman
Journal: Cancer Research (2009)

AACR Annual Meeting-- Apr 18-22, 2009; Denver, CO

Abstract The development of pulmonary metastasis is the major cause of death in osteosarcoma, and its molecular basis is poorly understood. In this study, we show that \#946;4 integrin is highly expressed in human osteosarcoma cell lines and tumor samples. Furthermore, highly metastatic MNNG-HOS cells have increased levels of \#946;4 integrin. Suppression of \#946;4 integrin expression by shRNA and disruption of \#946;4 integrin function by transfection of dominant negative \#946;4 integrin was sufficient to revert this highly metastatic phenotype in the MNNG-HOS model without significantly affecting primary tumor growth. These findings suggest a role for \#946;4 integrin expression in the metastatic phenotype in human osteosarcoma cells. In addition, we identified a previously uncharacterized interaction between \#946;4 integrin and ezrin, a membrane-cytoskeletal linker protein that is implicated in the metastatic behavior of osteosarcoma. The \#946;4 integrin-ezrin interaction appears to be critical for maintenance of \#946;4 integrin expression at both the RNA and protein levels. These data begin to integrate ezrin and \#946;4 integrin expression into a model of action for the mechanism of ostesarcoma metastases. Together, these findings demonstrate that \#946;4 integrin is highly expressed in human osteosarcoma cell lines and tumor samples and promotes tumor metastases. Thus, \#946;4 integrin blockade may represent a rational approach to inhibit metastatic disease in osteosarcoma.

Citation Information: In: Proc Am Assoc Cancer Res; 2009 Apr 18-22; Denver, CO. Philadelphia (PA): AACR; 2009. Abstract nr 5682.
Mitral Annulus Flattens in Ischemic Mitral Regurgitation: Geometric Differences Between Inferior and Anterior Myocardial Infarction
Authors: Nozomi Watanabe, Yasuo Ogasawara, Yasuko Yamaura, Nozomi Wada, Takahiro Kawamoto, Eiji Toyota, Takashi Akasaka, Kiyoshi Yoshida
Journal: Circulation (2005)

Background— New surgical strategies to restore the saddle shape of the mitral annulus are expected to increase annuloplasty effectiveness. Preoperative and postoperative configuration of the curved annulus, however, is difficult to quantify with 2-dimensional echocardiography. We sought to investigate the geometric deformity in the mitral annulus in ischemic mitral regurgitation (MR), comparing inferior and anterior myocardial infarction (MI) with the use of a custom quantitation software system with transthoracic 3-dimensional echocardiography. Methods and Results— We performed real-time 3-dimensional echocardiography in 23 patients with ischemic MR attributable to inferior MI or anterior MI and in 10 controls. Three-dimensional data were cropped into 18 radial planes, and we manually marked the annulus in mid systole. Three-dimensional annular images were reconstructed, and annular circumferences, areas, and heights were quantified. Annulus was significantly more dilated and flattened in ischemic MR than in controls and was further deformed in anterior MI as compared with inferior MI (control: circumference 9.9±0.7 cm, area 9.6±0.5 cm 2 , height 5.0±0.7 mm; inferior MI: circumference 11.5±1.2 cm [ P &lt;0.01 compared with control], area 11.4±2.0 cm 2 [ P &lt;0.05 compared with control], height 3.5±1.6 mm [ P &lt;0.05 compared with control]; anterior MI: circumference 14.2±2.4 cm [ P &lt;0.0001 compared with control, P &lt;0.05 compared with inferior MI], area 13.7±2.8 cm 2 ] P &lt;0.01 compared with control, P &lt;0.05 compared with inferior MI], height 1.7±1.5 mm [ P &lt;0.0001 compared with control, P &lt;0.05 compared with inferior MI]). Conclusions— Mitral annulus flattens in ischemic MR. Deformity of the mitral annulus was greater in anterior MI group than in the inferior MI group.
Drugs in Pregnancy and Lactation. A Reference Guide to Fetal and Neonatal Risk.
Authors: Gerald G. Briggs, Roger K. Freeman, Sumner J. Yaffe
Journal: Annals of Internal Medicine (1983)

ContentsForeword Roger K. Freeman, MD ... viiPreface Gerald G. Briggs, BPharm, FCCP ... ixIntroduction Sumner J. Yaffe, MD... xvInstructions for Use of the Reference Guide...xixMonographs ... 1-1615Appendix...1616Index...1633
Lag time to adverse events after radical prostatectomy and curative radiotherapy.
Authors: Camilla Thellenberg-Karlsson, Jon Fridriksson, Yasin Folkvaljon, Per Nilsson, David Robinson, Ingela Franck Lissbrant, Behdar Ehdaie, James Andrew Eastham, Anders Widmark, Pär Stattin
Journal: Journal of Clinical Oncology (2015)

49 Background: Men who are curatively treated with radiotherapy (RT) or radical prostatectomy (RP) for localized prostate cancer have long life expectancy but data on long term complications to treatment are scarce. Methods: In the nationwide, population-based Prostate Cancer data Base Sweden (PCBaSe), we identified men who underwent RT or RP between 1997 and 2012. Date of radiotherapy and dose of radiation were reassessed in an audit. For each case five controls from the background population, matched for age and county of residence, had been identified. The National Patient Register was used to identify diagnoses and surgical procedures indicating a complication to treatment, such as urinary incontinence, lower urinary tract symptoms and gastrointestinal symptoms, up to twelve years after treatment. The incidence rate ratio of complications for men who received RT and RP relative to their matched controls was calculated and relative risks (RR) were calculated for RT vs RP adjusted for treatment year, age, Charlson comorbidity index, educational level, PSA-level, clinical T stage and biopsy Gleason score. Results: In total, 37,420 men met the study criteria, of whom 12,534 had undergone RT and 24,886 had undergone RP. There were 186,624 matched controls. The risk of receiving any of the analyzed diagnoses or surgeries at 12 years after treatment was higher after RT; RT vs RP RR 1.20 (95%CI 1.08-1.34) and RT vs RP RR 1.49, (95% CI 1.36-1.64) for the diagnoses and surgical procedures respectively. At 3 years the risk of receiving any of the analyzed diagnoses was comparable between the treatments; RT vs RP RR 1.02 (95% CI 0.91-1.16) but the risk of undergoing any of the analyzed surgical procedures remained higher after RT during the entire study period. Men who underwent RP had a higher risk of being diagnosed or treated for urinary incontinence; RT vs RP RR 0.09 (95% CI 0.04-0.19) and RR 0.04 (95% CI 0.01-0.11) for the selected diagnoses and surgical procedures respectively. Conclusions: Complications after RP mostly occurred within the first 3 years after surgery whereas complications after RT were more frequent at a later date after treatment.