tbuckley/cabot-search huggingface dataset:
Abstract 3215: Left Ventricular Strain is Reduced in Remote Non-Diseased Myocardial Segments Following Myocardial Infarction in Patients With Type-2 Diabetes Mellitus
Authors: Allan M Seibert, James D Gladden, Michael Butler, Ravi Desai, Steven G Lloyd, Himanshu Gupta, Thomas S Denney, Raed A Aqel, Louis J Dell'Italia, Mustafa I Ahmed
Journal: Circulation (2009)
Abstract 13294: Evidence for Reduced Mortality in an Adult Cohort With Hypertrophic Cardiomyopathy
Authors: Ethan J Rowin, Martin S Maron, Susan A Casey, Mark S Link, Raymond H Chan, Evan Appelbaum, Ross F Garberich, John R Lesser, James E Udelson, Barry J Maron
Journal: Circulation (2013)

Background: Hypertrophic cardiomyopathy (HCM) has traditionally been regarded as a high risk disease, and the most common cause of sudden cardiac death (SCD) in the young. However, the overall mort...
Chagas disease in Switzerland: history and challenges
Authors: Y Jackson, F Chappuis
Journal: Eurosurveillance (2011)

Chagas disease, endemic in Latin America, is an emerging health problem in Europe affecting an estimated 80,000 persons. Around 60,000 Latin American migrants live in Switzerland, and cases of Chagas disease have been reported since 1979. As of June 2011, 258 cases have been diagnosed, mostly adults in the indeterminate phase of the chronic stage of the disease. Vertical transmission has been identified and there is a high potential for blood- and organ-borne transmission in the absence of systematic screening. Major challenges include (i) raising awareness among migrants and healthcare professionals, (ii) developing national protocols for screening and treatment targeting high-risk groups such as pregnant woman, newborns, migrants from highly endemic areas (e.g. Bolivia), and immunocompromised migrants, (iii) preventing blood- and organ-borne transmission by appropriate screening strategies, (iv) taking into account the social vulnerability of individuals at risk in the design and implementation of public health programmes, and (v) facilitating contacts with the communities at risk through outreach programmes, for example in churches and cultural groups.
Hepatic Resection for Colorectal Cancer Metastases
Authors: Charles R. Shumate
Journal: Liver Cancer (1998)

Achievement of long-term disease-free survival with surgical resection of metastases requires a single, predictable site of dissemination of the primary cancer. This situation occurs in a small but significant proportion of patients with recurrent colorectal carcinoma. In an ideal setting, treatment for primary or metastatic malignancy provides a high probability for complete response and a reasonable opportunity for long-term disease-free survival, it also has minimal side effects. Numerous methods have been advocated for the treatment of colorectal cancer liver metastases, but unfortunately none satisfies all of these criteria for an ideal treatment. Systemic chemotherapy, regional chemotherapy, cryotherapy, and surgical resection have advocates, but when multiple treatment methods are endorsed for the same problem it suggests that no one method is appropriate for all patients or that substantial treatment response is lacking.
CD44 Is Involved in Tumor Angiogenesis; an Activation Antigen on Human Endothelial Cells
Authors: Arjan W. Griffioen, Marieke J.H. Coenen, Cora A. Damen, Sandra M.M. Hellwig, David H.J. van Weering, Wim Vooys, Geert H. Blijham, Gerard Groenewegen
Journal: Blood (1997)
Abstract 3307: Tissue Specific Effects of the Transcription Factor Nuclear Factor Kappa B on Myocardial Ischemic Injury
Authors: Stefan Frantz, Charlotte Dienesch, Barbara Bayer, Manolis Pasparakis, Nikoletta Papadopoulou, Georg Ertl, Johann Bauersachs
Journal: Circulation (2009)

Nuclear factor kappa B (NF-κB) is a ubiquitous transcription factor activated by various stimuli implicated in ischemic injury including reactive oxygen species, hypoxia, and inflammatory cytokines. We demonstrated a detrimental role of NF-κB activation after myocardial infarction using mice with targeted deletion of the NF-κB subunit p50. However, the tissue specific role of NF-κB in cardiac ischemic injury has not been defined yet. Thus, we generated mice with cardiomyocyte restricted deletion of IKKγ(IκB-Kinase) by breeding floxed IKKγ with αMHC-Cre mice. IKK can phosphorylate the inhibitor of NF-κB IκB, a process necessary for NF-κB translocation to the nucleus. Thus, NF-κB activation is absent in IKK knockout (KO) mice. Offspring of αMHC-IKK-KO mice were vital with no cardiovascular phenotype. To study effects of the genotype on left ventricular remodeling wild type (WT) and MHC-IKK-KO mice underwent left coronary artery ligation followed by serial transthoracic echocardiography on day 1, 21, and 56 ...
Abstract 2821: Clinical and Echocardiographic Determinants of Left Ventricular Synchrony
Authors: Arnold Ng, Da T Tran, Mark Newman, Christine Allman, Jane Vidaic, Kim Touzel, Sidney T Lo, Andrew P Hopkins, Dominic Y Leung
Journal: Circulation (2007)

Background : Current research on predicting response to cardiac resynchronization therapy suggests quantification of left ventricular (LV) dyssynchrony. However, impact of age, gender and other variables on LV synchrony in healthy individuals is unknown. Methods : Echocardiography with color tissue Doppler was performed on 122 healthy volunteers (age 19 – 68 years, 64 men). LV systolic and diastolic synchrony were measured as the absolute basal lateral to septal wall delay (LSD) in peak myocardial Sm and Em velocities respectively. Systolic and diastolic synchrony were also measured as the standard deviation of time to 12 regional peak Sm (SDTs) and Em (SDTe) velocities. Mean Sm and Em velocities were calculated from 6 basal segments. Results : Mean QRS duration was 87 ± 12msec. Mean systolic LSD and SDTs were 57.5 ± 39.7msec and 37.1 ± 17.4msec respectively. Women had significantly higher systolic LSD (74.1 ± 40.2 vs 42.2 ± 32.8msec, p &lt; 0.001) and SDTs (44.5 ± 16.1 vs 30.2 ± 15.7msec, p &lt; 0.001) than men. SDTs was correlated with LV wall stress (r = 0.23, p = 0.01) and mean Sm (r = 0.40, p &lt; 0.001). Gender (p &lt; 0.001) and mean Sm (partial r = -0.31, p &lt; 0.001) independently predicted SDTs (multiple R = 0.51, p &lt; 0.001) whereas only gender independently predicted systolic LSD. Mean diastolic LSD and SDTe were 15.3 ± 15.6msec and 17.3 ± 6.7msec respectively. There were no gender differences in diastolic LSD or SDTe. Diastolic LSD was correlated with mean Em (r = -0.20, p = 0.03), isovolumic relaxation time (IVRT, r = 0.24, p = 0.01), mitral E/A ratio (r = -0.21, p = 0.02), pulmonary S/D ratio (r = 0.23, p = 0.01) and systolic blood pressure (r = 0.22, p = 0.02). Only IVRT independently predicted diastolic LSD. SDTe correlated with age (r = 0.42, p &lt; 0.001), mean Em (r = -0.73, p &lt;0.001), mitral E/A ratio (r =0.40, p &lt;0.001), pulmonary S/D ratio (r =0.42, p &lt;0.001), IVRT (r = 0.51, p &lt; 0.001), systolic blood pressure (r = 0.25, p = 0.005) and LV mass (r = 0.21, p = 0.019). Mean Em (partial r = -0.34, p &lt; 0.001) and IVRT (partial r = 0.31, p = 0.001) independently predicted SDTe (multiple R = 0.58, p &lt; 0.001). Conclusions : In healthy individuals, 1) women have higher systolic but not diastolic synchrony indices than men; 2) systolic function impacts on systolic synchrony, diastolic function impacts on diastolic synchrony.
Abstract 2449: Procedural results and Acute Complications in Stenting Native and Recurrent Coarctation of the Aorta: A Multi-Institutional Study
Authors: Satinder K Sandhu, Thomas Forbes, Zahid Amin, Evan M Zahn, David Nykanen, Moore Phillip
Journal: Circulation (2006)

Background: We report a multi-institutional experience with intravascular stenting for treatment of coarctation of the aorta. Methods and Results: Medical records from 17 institutions were reviewed...
Abstract 48: Incidence, Outcome and Characteristics of Cardiac Arrest at Schools
Authors: Tatsuya Nishiuchi, Yasuaki Hayashino, Shunichi Fukuhara, Taku Iwami, Tetsuhisa Kitamura, Yasuyuki Hayashi, Kentaro Kajino, Atsushi Hiraide, Yasumitsu Mizobata
Journal: Circulation (2011)

Background Although automated external defibrillators (AEDs) are widely prevalent in public places in Japan, the impact of implementing AEDs at schools remains unclear. Objectives To clarify the incidence, outcomes, and characteristics of out-of-hospital cardiac arrest (OHCA) at schools. Methods The Utstein Osaka Project is a population-based cohort study aimed at identifying the incidence and outcomes of OHCA in Osaka (population of 8.8 million), Japan. From the data collected according to the Utstein Recommendations, we extracted cases of OHCA at schools between Jan. 1, 2005 and Dec. 31, 2009. In this study, the term “school” included all educational institutions defined by the Japanese School Education Act. Primary outcome measures were one-month survival and good neurological outcome, as defined as Cerebral Performance Category 1 or 2. Results During the study period, 34 cases of non-traumatic OHCA occurred at schools among the total of 33,901 registered OHCA cases. Of these 34 cases, 14 (41%) patients achieved one-month survival and 11 patients (32%) had good neurological outcome. A total of 23 (68%) patients, which consisted of 10 students, 4 school officials, and 9 adults not affiliated with schools, presented ventricular fibrillation (VF) as the first monitored rhythm. Of the patients presenting with VF, 12 (52%) survived one month after cardiac arrest and 10 (43%) had good neurological outcome. Twelve of the patients had a history of cardiac disease, with seven collapsing during physical exercise. An additional five patients without a history of cardiac disease experienced OHCA with VF during exercise. Citizen rescuers applied AED pads to ten patients and administered electrical shocks to five patients, with three of these patients surviving without neurological deficits. Conclusions Approximately 70% of the OHCA patients at schools presented VF as the first monitored rhythm. Most were students or adults with either a past history of cardiac disease or who were performing physical exercise. The characteristics of OHCA cases revealed in this study should be taken into consideration when creating and implementing medical emergency response plans for cardiac arrest at schools in Japan.
Abstract 18759: Poor Quality of Life Predicts Adherence to a Weight-Loss Intervention in Overweight and Obese Patients With Heart Failure
Authors: Marjan Motie, Terry A Lennie, Lorraine S Evangelista
Journal: Circulation (2013)

Background: Poor quality of life (QOL) has a known association with cardiometabolic risk that is also correlated with weight, diet, physical activity, and smoking. However, the effect of QOL on adherence (i.e. completing the study protocol) to a dietary intervention in heart failure (HF) patients has not been studied. We investigated the relationship between QOL and adherence with completing a 3 month intensive weight loss intervention in a cohort of obese HF patients with metabolic complications and tested a model that included age, gender, race, baseline weight, functional status, and QOL on adherence. Methods: Data on QOL of overweight and obese patients with HF who participated in a larger clinical trial comparing a high protein and standard protein diet were collected at baseline and 3 months using the Minnesota Living with Heart Failure (MLHF) Questionnaire. Comparisons were made between participants who completed the 3 month dietary intervention (i.e. completers) and participants who did not (i.e. non-completers). Results: Forty-nine patients - mean age 59.1 ± 9.8; weight 248.8 ± 29.7 pounds; EF 37.3 ± 12.5%; peak VO2 12.5 ± 3.7 mg/kg/ml; 55% White; 20% Hispanics; 16% Blacks; 8% Asians - participated in the study; 34 (70%) completed the intensive phase of the dietary intervention. There were statistically significant differences in QOL scores between completers and non-completers (Table 1). There were no age or gender differences between completers and non-completers; Whites were less likely to complete the intervention compared to their counterparts (p = 0.046). In a model controlling for age, gender, race, baseline weight, and functional status, QOL explained an additional 19% of the variance in adherence. Conclusion: Our findings elucidate the need to integrate QOL assessments and strategies in clinical trials involving dietary interventions as potential key to enhancing adherence.
Abstract 14207: C-Reactive Protein and Lipid Levels to Predict the Risk of Coronary Heart Disease in Statin-Treated Stable Coronary Patients: Prospective Results From the Treating to New Targets (TNT) Study
Authors: Benoit J Arsenault, S. Matthijs Boekholdt, Prakash Deedwania, David A DeMicco, Weihang Bao, Gregory M Preston, David D Waters, John C LaRosa, Philip Barter, John J Kastelein
Journal: Circulation (2010)

Background: Studies have shown that, individuals with elevated C-reactive protein (CRP) levels may be at increased cardiovascular disease (CVD) risk independently of plasma levels of low-density lipoprotein cholesterol (LDL-C). In addition, several studies have shown that the apolipoprotein B/apolipoprotein A-I (apoB/apoA-I) ratio performs better than LDL-C in predicting cardiovascular risk. Whether CRP levels add to the predictive value of the apoB/apoA-I ratio in statin-treated patients with stable coronary heart disease (CHD) is unknown. Methods and Results: We performed a nested case-control study in the TNT (Treating to New Targets) study population, a randomized trial that compared the efficacy of high (80mg) vs. low (10mg) dose atorvastatin for the secondary prevention of CVD. Fasting levels of standard lipids and of CRP were obtained after an 8-week run-in period on atorvastatin 10 mg in 493 patients who experienced CVD during the 4.9 years of study follow-up and in 1013 treatment-matched controls...
Abstract 1949: The Protein Kinase MAP4K4 Is Activated in Failing Human Hearts and Mediates Cardiomyocyte Apoptosis in Experimental Models, in vitro and in vivo
Authors: Min Xie, Dou Zhang, Sam C Wang, Motoaki Sano, XiaoZhen Wang, Jennifer S Pocius, George E Taffet, Lloyd H Michael, Mark L Entman, Douglas L Mann, Tse-Hua Tan, Michael D Schneider
Journal: Circulation (2007)

Mitogen-activated protein kinases (MAPKs) have been implicated in cardiac muscle hypertrophy, apoptosis, and heart failure, but relatively little is known of the proximal MAP4Ks that might couple cardiac stress signals to downstream effector kinases. Previously we have shown that epitope-tagged MAP4K4 (hematopoietic progenitor kinase/germinal center kinase-like kinase, HGK) was activated by diverse apoptotic signals in cultured cardiomyocytes and transgenic mouse hearts. Here, we report results for the activation of MAP4K4 in the hearts of patients undergoing therapeutic transplantation, and for the functional consequences of disrupting endogenous MAP4K4 by RNA interference. Compared with 10 control donor hearts obtained at overlapping ages, MAP4K4 activity increased in all subjects with dilated (4.5-fold; N = 13), hypertrophic (4-fold; N = 5), ischemic (2.5-fold; N = 6) and adriamycin-induced cardiomyopathy (3-fold, N = 2; p &lt; 0.001 for all four groups). Activity of the MAP4K4 target, TGFbeta-activated kinase-1 (TAK1/MAP3K7), and the executioner caspase, caspase-3, increased concordantly in all subjects. In mouse myocardium, each of four biological signals for cardiomyocyte apoptosis induced the kinase activity of MAP4K4: biomechanical stress, ischemia/reperfusion injury, and gain-of-function mutations for TNFalpha and Gq. Analogous results were seen in cultured cardiomyocytes, using oxidative stress, ceramide and the cardiotoxic anti-cancer drug doxorubicin. Transgenic expression of MAP4K4 in myocardium produced little or no baseline phenotype, but markedly sensitized the myocardium to apoptosis caused by Gq. In culture, we proved that MAP4K4 induces apoptosis via TAK1, JNK, and the mitochondrial death pathway. As predicted, ceramide-induced and hydrogen peroxide-induced apoptosis was suppressed using RNA interference to silence expression of MAP4K4. Thus, MAP4K4 is activated in response to many specific cardiac death signals, and mediates cardiac apoptosis in vitro and in vivo. The prevalent activation of MAP4K4 in failing human hearts and the pro-death actions of the kinase suggest that MAP4K4 is a possible therapeutic target in the treatment of apoptotic cardiomyopathies.
Abstract 2571: Long-Term Endothelial Dysfunction after Coronary Artery Stenting with Drug-Eluting Stent Associated with Local Inflammatory Response
Authors: Tetsuzo Wakatsuki, Koji Yamaguchi, Toshiyuki Niki, Kenya Kusunose, Kunihiko Koshiba, Hirotsugu Yamada, Takeshi Soeki, Syusuke Yagi, Takashi Iwase, Masashi Akaike, Masataka Sata
Journal: Circulation (2008)

Endothelial function remains chronically abnormal after vascular injury associated with coronary intervention. The long-term effects of drug-eluting stent (DES) on endothelial function are not known. We evaluated the endothelial-dependent vasomotor function and local release of pentraxin3 (PTX3) as a local inflammatory marker in nonrestenotic coronary arteries more than six months following DES and bare metal stent (BMS) implantation. Fifty-two patients treated six months earlier with a coronary stenting for isolated proximal left anterior descending (LAD) stenosis, with no evidence of restenosis, were studied. Twenty patients had been stented with BMS, and 32 had been with DES. Changes in diameter at distal site of the stented LAD in response to intracoronary acetylcholine (Ach) infusions (1,3,10,30 μg/min) were assessed by quantitative angiography. At the completion of the protocol, a 2mg bolus of isosorbide dinitrate (ISDN) was injected into the LAD. We also measured serum PTX3 levels sampled in coronary sinus (CS) and sinus of Valsalva (V). Results: The two groups had similar risk factors for endothelial dysfunction. The mean percent change in the diameter of the stented LAD by Ach injection was significantly more in the DES group than in the BMS group (−38.9±6.1 vs. −19.2±6.7 %, p&lt;0.01). There was no significant difference in maximal dilation achieved by ISDN infusion between the two groups (34.6±6.6 vs. 31.2±4.6 %, NS). The translesional PTX3 gradient (CS-PTX3 minus V-PTX3) was higher in the DES group than in the BMS group (+0.11±0.05 vs. −0.01±0.05 ng/ml, p&lt;0.01). More severe endothelial dysfunction was observed long term after DES implantation as compared to BMS. These findings were associated with an increased local inflammatory response to DES stenting.
Abstract 9310: Gender and Outcomes Following Primary Prevention ICD Placement: Analysis of the NCDR ICD Registry
Authors: Andrea M Russo, Stacie L Daugherty, Frederick A Masoudi, Yongfei Wang, Joanne Mazzarelli, Jeptha Curtis, Rachel Lampert
Journal: Circulation (2012)

Background: Due to the small numbers of women enrolled in implantable cardioverter defibrillator (ICD) trials, outcome for women has not been well-described. This study compares intermediate-term outcomes in a large cohort of men and women receiving single or dual chamber ICDs for primary prevention. Methods: 38,912 initial implants (25% women) with single or dual chamber ICDs for primary prevention between 2006 and 2009 in the NCDR ICD Registry were identified. Baseline characteristics and outcomes, including complications, six-month heart failure (HF) readmission, and six-month mortality were compared between men and women using chi-square tests for categorical variables and unbalanced t-tests for continuous variables. Complications were considered within 30 or 90 days of implantation, including pneumothorax requiring chest tube, hematoma requiring transfusion or evacuation, tamponade, or death within 30 days, or mechanical complications with system revision, device-related infection, or post-index ICD within 90 days. The differences in outcomes between genders were also examined through multivariable logistic regression models adjusting for possible confounders. Results: Differences in baseline characteristics and drug therapy were noted between men and women (Table). Complications at 30 or 90 days, 6-month mortality, and 6-month HF readmission were significantly more frequent in women (p&lt;0.001 for all). Differences in complications or mortality (OR 1.40, 95% CI 1.27,1.54, p&lt;0.001), or HF readmission (OR 1.34, 95% CI 1.25, 1.44, p&lt;0.001) persisted after adjusting for differences in baseline characteristics and device type. Conclusions: Following ICD implantation for primary prevention indications, complication rates, six-month HF readmission rates, and six-month mortality rates are higher in women than men. Whether these gender differences in outcome impact the benefit of ICDs in women requires further investigation.
Abstract 354: Host Immune Factors and Donor Adult Stem Cells Mediate Myocardial Ischemia Repair
Authors: Jakub Tolar, Elizabeth Braunlin, Ron T McElmurry, Christopher J Lees, Megan Riddle, Abdul M Mansoor, Jianyi Zhang, Bruce R Blazar
Journal: Circulation (2008)

Cellular therapy with non-hematopoietic adult stem cells (ASC) has emerged as a novel strategy for treatment of myocardial infarction (MI). Cells from non-identical donors, however, are typically rejected by the immune system of recipient. To overcome this barrier to transplantation we induced MI by left coronary artery ligation followed by direct intramyocardial injection of ASC or saline in cohorts of syngeneic C57BL/6 (B6) immune competent versus B6 Rag/IL2Rγc (Rag/γc) T-, B- and natural killer-cell immune deficient mice. We made an unexpected observation that heart function was significantly improved in ASC-treated B6 mice, but not in ASC-treated Rag/γc mice; and that the beneficial effect of ASC was inversely correlated with ASC persistence (i.e., ACS were rejected by B6 mice but engrafted in Rag/γc mice). As the donor cells were rejected within several weeks by B6 animals we hypothesized that the host immune system and ASC provided trophic signals for cardiac repair early after injury. In search for anatomical correlation, we first assessed changes in capillary density. Four weeks after MI, significantly more capillaries (normalized to number of nuclei) were observed in the border zone of B6 animals treated with ASC versus saline (p = 0.01), and significantly fewer capillaries were found in the infarct zone when B6 animals (treated with ASC) were depleted of T-cells and NK-cells (p = 0.03). To gain mechanistic insight into the early events in the ASC-mediated repair, next we have assessed one week after MI ± ASC messenger RNA expression of genes known to be engaged in angiogenesis. In B6 mice the most prominent change in response to MI injury was 17-fold increased expression of tissue inhibitor of metalloproteinases 1. The ASC mediated response to MI injury was defined by increased expression of fibroblast growth factor 2, integrin αV, phophorylated form of vascular endothelial growth factor receptor 2 and endothelial-specific receptor tyrosine kinase (all p &lt; 0.01). These data are the first to define the paracrine tissue repair factors necessary to produce therapeutic benefit in response to donor ASC after MI. Importantly, our data also suggest that MI is not solely a heart lesion, but rather a systemic inflammatory condition controlled by host immune system. This research has received full or partial funding support from the American Heart Association, AHA National Center.