tbuckley/cabot-search huggingface dataset:
The White Way
Authors: Kristen M Quaranta
Journal: JAMA (2006)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
An L-type calcium-channel gene mutated in incomplete X-linked congenital stationary night blindness
Authors: Tim M. Strom, Gerald Nyakatura, Eckart Apfelstedt-Sylla, Heide Hellebrand, Birgit Lorenz, Bernhard H. F. Weber, Krisztina Wutz, Nadja Gutwillinger, Klaus Rüther, Bernd Drescher, Christian Sauer, Eberhart Zrenner, Thomas Meitinger, Andre Rosenthal, Alfons Meindl
Journal: Nature Genetics (1998)
Papilledema Outcomes from the Optical Coherence Tomography Substudy of the Idiopathic Intracranial Hypertension Treatment Trial
Authors: Peggy Auinger, Mary Durbin, Steven Feldon, Mona Garvin, Randy Kardon, John Keltner, Mark Kupersmith, Patrick Sibony, Kim Plumb, Jui-Kai Wang, John S. Werner
Journal: Ophthalmology (2015)
Stress and Women Physicians.
Authors: Marjorie A. Bowman, Deborah I. Allen
Journal: Annals of Internal Medicine (1986)

This second edition of Stress and Women Physicians has been completely updated to include new research material. It reflects the growing interest in what problems women face in the medical profession and how women cope with these problems. The authors have added interview material with commentaries and personal statements from practising women physicians and expanded the discussion in every chapter. They examine the alternatives to full-time medical practice and cover more thoroughly than before the social support that women professionals need and receive. This book gives practical advice to women physicians and should also be helpful for women contemplating a career in the medical profession.
HYPERPARATHYROIDISM, WITH FAILURE TO RECALCIFY AFTER REMOVAL OF PARATHYROID ADENOMA (A CASE REPORT)
Authors: Charles P. Voltz, Katharine Smull
Journal: Annals of Internal Medicine (1944)

Case Reports1 August 1944HYPERPARATHYROIDISM, WITH FAILURE TO RECALCIFY AFTER REMOVAL OF PARATHYROID ADENOMA (A CASE REPORT)CHARLES P. VOLTZ, M.D., KATHARINE SMULL, M.D.CHARLES P. VOLTZ, M.D.Search for more papers by this author, KATHARINE SMULL, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-21-2-329 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptHyperparathyroidism due to adenoma is usually followed by recalcification after removal of the tumor. The present report cites a case which was unusual in its failure to deposit calcium in the bones during a five year period after removal of the tumor, despite lack of evidence of a recurrence of hyperparathyroidism. The preoperative and immediate postoperative course of this patient was reported by Gutman and Parsons,1 and it will only briefly be outlined here.CASE REPORTThe patient, M. B., was a 54 year old Syrian spinster who was admitted to the Presbyterian Hospital in June 1937 with a 13...Bibliography1. GUTMANPARSONS ABWB: Hyperparathyroidism simulating or associated with Paget's disease; with three illustrative cases, ANN. INT. MED., 1938, xii, 13-31. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: New York, N. Y.*Received for publication July 27, 1942.From First Medical Division, Welfare Hospital, and Department of Medicine, Columbia University. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byFractures resulting from primary hyperparathyroidism 1 August 1944Volume 21, Issue 2Page: 329-332KeywordsAdenomasBoneCalciumHospital medicineHyperparathyroidismParathyroid tumors ePublished: 1 December 2008 Issue Published: 1 August 1944 PDF downloadLoading ...
A Mutual Anxiety
Authors: Caroline Wellbery
Journal: JAMA (2003)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
‘A detective look’ at hair biopsies from African-American patients
Authors: M. Miteva, A. Tosti
Journal: British Journal of Dermatology (2012)

A patient's ethnicity can be an important clue in the diagnosis of scarring alopecia as some disorders such as traction alopecia (TA) and central centrifugal cicatricial alopecia (CCCA) are more prevalent in or exclusive to African-Americans.To perform a retrospective review of 60 scalp biopsies from African-American patients including 25 cases of CCCA, 22 cases of TA, five cases of frontal fibrosing alopecia, three cases of discoid lupus erythematosus, three cases of hair breakage and two cases of alopecia areata.Serial horizontal and vertical sections were examined.Features characteristic of the African-American scalp include: golf club-shaped bulb, elliptical shape of the hair shaft, asymmetrical outer root sheath and paired grouping of hair follicles. Clues to the diagnosis of CCCA include: premature desquamation of the inner root sheath, goggles and naked hair shafts in fibrous streamers. Diagnosis of TA is suggested by preserved sebaceous glands along with follicular miniaturization and drop-out.The clues reported here aim to help the dermatopathologists to: recognize at a glance that they are dealing with a scalp biopsy from an African-American patient; make the most probable diagnosis by connecting the clues (even if only vertical sections are present); and understand the morphological basis for the susceptibility of the African hair to damage.
Assessment and Accountability
Authors: Arnold S. Relman
Journal: New England Journal of Medicine (1988)

Since the end of World War II the United States has seen two revolutions in its medical care system. It is now on the threshold of a third.The first of these began in the late 1940s and early1950s and continued through the 1960s. It can be described as the Era of Expansion and was characterized by rapid growth in hospital facilities and the number of physicians, new developments in science and technology, and the extension of insurance coverage to the majority of the population. Medical schools increased and produced an army of new specialists trained in the use . . .
Dutch illegal immigrants have poor health care
Authors: Tony Sheldon
Journal: BMJ (2001)

The health of illegal immigrants in the Netherlands is endangered by their dependence on access to a relatively small network of doctors who do not object to their illegal status but are often overworked, according to a survey by Nivel (the Netherlands Institute of Health Services Research).

The survey of more than 400 GPs, midwives, and hospital emergency care staff identified certain problems that were more common among illegal immigrants than in the general population as a whole. …
PD-1hiTIM-3+ T cells associate with and predict leukemia relapse in AML patients post allogeneic stem cell transplantation
Authors: Y Kong, J Zhang, D F Claxton, W C Ehmann, W B Rybka, L Zhu, H Zeng, T D Schell, H Zheng
Journal: Blood Cancer Journal (2015)

Abstract Prognosis of leukemia relapse post allogeneic stem cell transplantation (alloSCT) is poor and effective new treatments are urgently needed. T cells are pivotal in eradicating leukemia through a graft versus leukemia (GVL) effect and leukemia relapse is considered a failure of GVL. T-cell exhaustion is a state of T-cell dysfunction mediated by inhibitory molecules including programmed cell death protein 1 (PD-1) and T-cell immunoglobulin domain and mucin domain 3 (TIM-3). To evaluate whether T-cell exhaustion and inhibitory pathways are involved in leukemia relapse post alloSCT, we performed phenotypic and functional studies on T cells from peripheral blood of acute myeloid leukemia patients receiving alloSCT. Here we report that PD-1 hi TIM-3 + cells are strongly associated with leukemia relapse post transplantation. Consistent with exhaustion, PD-1 hi TIM-3 + T cells are functionally deficient manifested by reduced production of interleukin 2 (IL-2), tumor necrosis factor-α (TNF-α) and interferon-γ (IFN-γ). In addition, these cells demonstrate a phenotype consistent with exhausted antigen-experienced T cells by losing T N and T EMRA subsets. Importantly, increase of PD-1 hi TIM-3 + cells occurs before clinical diagnosis of leukemia relapse, suggesting their predictive value. Results of our study provide an early diagnostic approach and a therapeutic target for leukemia relapse post transplantation.
Abstract 18299: Are Omega-3 (Fish Oil) Supplements Proarrhythmic?
Authors: Chun Li, Sarmistha Mazumder, Ingrid M Bonilla, Quanhua He, Yoshinori Nishijima, George E Billman, Cynthia A Carnes
Journal: Circulation (2010)

Data from clinical trials evaluating the benefits of fish oil (omega-3 polyunsaturated fatty acids, ω-3 PUFA) supplements on sudden cardiac death have been variable; some studies reported reduced cardiac mortality while others reported either no benefit or increased adverse events. An explanation for these variable results remains to be determined. Methods: Post-MI dogs in which ventricular fibrillation could not be induced by acute ischemia during exercise (VF-) were assigned to ω-3 fatty acid ethyl esters (1–4 grams/day for 3 months, n=13) or matched corn oil supplements (n=11). Post-treatment, arrhythmia inducibility was re-evaluated with the exercise + ischemia test followed by left ventricular myocyte isolation. Perforated whole cell patch clamp recordings were used to elicit action potentials (T=35±0.5°C). Results: The exercise + ischemia test failed to induce arrhythmias in any placebo treated animal. In marked contrast, this test provoked VF in 4 of 13 ω-3 PUFA treated dogs; in addition 1 dog died...
二、高甘油三酯血症有何危害？如何治疗？
Authors: 徐成斌
Journal: BMJ (2007)

血清甘油三酯的分类：正常为〈150mg／dl（1．7mmol／L），临界升高150～199mg／dl，升高200～499mg／dl，极高≥500mg／dl。研究表明甘油三酯升高是动脉粥样硬化、冠心病及其他缺血性心血管病的一项独立危险因素。甘油三酯水平升高作为冠心病阳性相关的标志：①高甘油三酯血症为富含致动脉粥样硬化的甘油三酯脂蛋白（Triglyceride-rich lipoprotein，TRL）的标志。②富含甘油三酯脂蛋白是指乳糜微粒（CM）及极低密度脂蛋白（VLDL）含的致粥样硬化残粒。
Percival's Medical Ethics.
Authors: A. G. Nicholls
Journal: Annals of Internal Medicine (1975)

For those interested in natural history, this is an important book.The collecting of natural history specimens has been popular for centuries and for a variety of reasons.The disposal of the resulting collections by auction has taken place in this country since the late eighteenth century, and nearly 1,600 sales have been conducted.One of the important features of any sale is the catalogue prepared for it, for this may often be the only information we now have of a private collection.This, of course, is true for any type of auctioned material.Sothebys have had the excellent idea of listing all the sales of natural history items that have taken place in the British Isles.First there are fascinating essays describing the various auctions, of entomological, botanical, ornithological, oological, fossil, mineral and shell specimens, each written by an expert.Thereafter the sales, ranging from 22 March 1710 to 12-15 December 1972, are listed (pp.57-180).The source of the material, its nature, the auctioneer, and the whereabouts ofa catalogue are recorded, with interesting footnotes; there is an index of the names of the collections, the vendors and the collectors.This volume is, therefore, an invaluable source-book for workers in natural history.Its production is of a high order of excellence, with the thoughtful inclusion of a few blank terminal pages for the owner's notes and additions.Admittedly the labour would be greater, but would that someone could produce a similar record of book auction sales!
Abstract 1994: Cd44s is of functional importance for hepatocellular carcinoma (hcc) extra-hepatic metastases through activation of sdf-1a/cxcr4 axis
Authors: Wenwei Zhu, Lei Guo, Qinhai Ye
Journal: Cancer Research (2014)

Abstract Background: CD44 has been reported as a promoter of metastasis in several tumors, including HCC. In this study, we elucidated the critical role of CD44 in HCC metastasis, especially in distant metastasis as well as the underling mechanism. Methods: The expression of CXCR4, CD44 and their associated cellular signaling cascades, involving Akt and MAP Kinases, were determined by Western blotting. We also established CD44-deficient MHCC-97H cell lines by transfection with miRNA-CXCR4 plasmids and determined cell migration/invasion activity in a transwell assay.The prognostic value of CD44 and it's combination with CXCR4 was further evaluated. Results: HCC patients with higher CD44 have poor prognosis, including reduced disease-free and overall survival, and individuals with distinct metastasis have higher frequency expression of CD44. We found that expression of CD44 was positively related to metastatic potential of HCC cell lines, and modified cells with CD44high showed higher aggressiveness in vitro, and higher metastatic ability in vivo. Furthermore, the mechanism of CD44 improving the invasion activity of HCC cells was though the SDF-1a/CXCR4 axis. CD44 can activate the PI-3K/Akt pathway through binding HA, which can up-regulate the expression of CXCR4. CD44 combined with CXCR4 is a promising independent predictor of tumor recurrence and survival in hepatocellular carcinoma patients. CONCLUSIONS: CD44s is a potent predictor for extra-hapatic metastasis and overall survival of HCC patients. Our findings also provided evidence that the process of HA/CD44-induced CXCR4 expression is functional important for the invasiveness and metastasis of HCC. Therefore, the CD44-SDF-1α/CXCR4 system may be a new therapeutic target for treating HCC metastasis. Note: This abstract was not presented at the meeting. Citation Format: Wenwei Zhu, Lei Guo, Qinhai Ye. Cd44s is of functional importance for hepatocellular carcinoma (hcc) extra-hepatic metastases through activation of sdf-1a/cxcr4 axis. [abstract]. In: Proceedings of the 105th Annual Meeting of the American Association for Cancer Research; 2014 Apr 5-9; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2014;74(19 Suppl):Abstract nr 1994. doi:10.1158/1538-7445.AM2014-1994
Abstract 9971: Rock2 is the Predominant Rho Kinase Involved in Thrombin Receptor-Mediated Vascular Permeability
Authors: Cora M Beckers, Nebosja Knezevic, Mohammad Tauseef, Ramaswamy Krishnan, Kavitha Rajendran, Jurjan Aman, Jan van Bezu, Victor W., Dolly Mehta, Geerten P Van Nieuw Amerongen
Journal: Circulation (2011)

Objective Endothelial barrier function is critically regulated by Rho kinase. Basal Rho kinase activity is essential for barrier maintenance, but its enhanced activity induced by vascular permeability factors such as thrombin causes barrier dysfunction involving acto-myosin contractility. Here, we investigated the isoform-specific roles of Rho kinase (ROCK1 and ROCK2) in regulating endothelial (hyper-)permeability. Methods Endothelial hyperpermeability was induced in vitro by thrombin and was assessed by the passage of a tracer or by Electrical Cell-substrate Impedance Sensing (ECIS). In the intact lungs of untreated and ROCK1/2 siRNA-transducing mice vascular permeability was induced by TFLLRN, an agonist of the thrombin receptor PAR1 and was assessed by lung Evans blue dye extravasation and wet-dry weight ratios of isolated lungs. Contractile forces were mapped by traction force microscopy. Results Downregulation of ROCK2, but not ROCK1 expression attenuated PAR1-mediated hyperpermeability of endothelial monolayers and the pulmonary microvasculature. Simultaneous downregulation of both Rho kinase isoforms further reduced the hyperpermeability. Surprisingly, inhibition of ROCK2 did not affect the net thrombin-induced contractile force enhancements and the formation of thrombin-induced F-actin stress fibers, but lowered basal traction forces, enforcing the basal barrier function of the endothelium. Conclusions These data show that ROCK2, but not ROCK1 is the critical Rho kinase for thrombin-induced endothelial barrier disruption. Rather than mediating the evoked contractile force enhancements through the formation of stress fibers, ROCK2 activity is of vital importance for the basal isometric tone of the endothelium. Thus, selective pharmacological inhibition of basal traction forces could provide a novel approach to stabilize the endothelial barrier, and limit vascular leak during derailed inflammatory episodes.
Autotaxin controls breast cancer growth and metastasis in preclinical mouse models
Authors: Marion David, Blandine Deux, Claire-Marie Serre, Bendriss-Vermare Nathalie, Caux Christophe, Jean-Sebastien Saulnier-Blache, Philippe Clezardin, Olivier Peyruchaud
Journal: Cancer Research (2008)

344  Autotaxin (ATX, NPP-2) is a glycoprotein secreted at basal level in normal tissues. Increased ATX expression was reported in primary tumors of many cancers including breast cancers. ATX augments invasiveness of transformed cells and its level of expression correlated with invasion capacity of breast cancer cells. Recently, biological functions of ATX were linked to its lysophospholipase D activity which allows the formation of lysophosphatidic acid (LPA) from a precursor substrate, lysophophatidylcholine. Using preclinical animal models, we have recently showed that LPA is produced in vivo in the tumor microenvironment wherein it stimulates the growth of breast cancer cells and the progression of bone metastases. In this study, we address the role of ATX in vivo on breast cancer growth and metastasis. We first use a sub-clone (MDA-B02) cells of human breast cancer MDA-MB-231 cell line which has a high tropism to bone. These cells do not express ATX at steady state. Therefore, after transfection, we generated MDA-BO2/ATX cell lines which secreted active ATX. After intravenous injection to BALB/c nude mice, we observed that de novo expression of ATX in these cells induced a two-fold increase in the extent of osteolytic bone metastases. Furthermore, using a subcutaneous xenographt model, we observed that expression of ATX enhanced the growth of primary MDA-BO2/ATX tumors. In vitro, we observed that in the presence of LPC, ATX expression enhanced the proliferation and invasion of MDA-BO2/ATX cells compared to parental cells. Then, we used the 4T1 cell line that derived from a single mouse mammary tumor. These cells recapitulate the distinct steps of metastasis when engrafted into the mammary glands of syngenic normal BALB/c mice. We first observed that 4T1 cells express ATX. Therefore, using shRNAi strategy, we generated stable 4T1-siATX cell lines silenced for the expression of ATX. In vivo, we found that 4T1-siATX cells were markedly affected for their local invasiveness capacity and also for their ability to generate distant metastases to the lungs (80% decreased in numbers and areas of lung metastases). Overall, our results demonstrate that ATX controls tumor growth and metastatic dissemination of breast cancer cells. These data might impact the new growing development of anti-lysophospholipid therapeutic strategies for patients with breast cancers.
A question of confidence
Authors: Trevor Stammers
Journal: BMJ (2001)

She took so long in answering the door and was so breathless when she did so, that I immediately thought that Agnes should be in hospital. A brief chat and examination in her cramped sitting room confirmed that she was in severe left ventricular failure, which had been worsening for nearly a week. I had never met her before, and she was obviously distressed that my partner, who usually sees her, could not come.

“I think we should send for an ambulance to get you into hospital for a few days,” I ventured.

Her face froze with fear: “Oh, no. Hospitals are such awful places—noisy, dirty, and, of course, you read about so many mistakes being made and old …