STUDIES OF CHOLINESTERASE ACTIVITY. V. SERUM CHOLINESTERASE IN PATIENTS WITH CARCINOMA
Authors: H J WETSTONE, R V LAMOTTA, A BELLUCCI, R TENNANT, B V WHITE
Journal: Annals of Internal Medicine (1960)

Article1 January 1960STUDIES OF CHOLINESTERASE ACTIVITY. V. SERUM CHOLINESTERASE IN PATIENTS WITH CARCINOMAHOWARD J. WETSTONE, M.D., RUDOLPH V. LAMOTTA, M.D., ALDO BELLUCCI, M.D., ROBERT TENNANT, M.D., BENJAMIN V. WHITE, M.D., F.A.C.P.HOWARD J. WETSTONE, M.D.Search for more papers by this author, RUDOLPH V. LAMOTTA, M.D.Search for more papers by this author, ALDO BELLUCCI, M.D.Search for more papers by this author, ROBERT TENNANT, M.D.Search for more papers by this author, BENJAMIN V. WHITE, M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-52-1-102 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptAlthough several reports have described a depression of serum cholinesterase activity in patients with neoplastic disease, a clear correlation has not been established between the quantitative level of enzyme activity, the site of origin and degree of spread of the tumor, the function of the liver and the clinical status of the individual patient. In the absence of a satisfactory explanation of this phenomenon, further investigations of the metabolism of the enzyme in the tumor state seemed warranted.Serum cholinesterase (pseudocholinesterase) is manufactured by the liver1-5and found in serum, plasma, pancreas, brain and certain other body tissues.6-9It is...Bibliography1. 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Wetstone, M.D., 80 Seymour Street, Hartford, Connecticut. 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