Acute Hepatitis A Virus Infection Without IgM Antibodies to Hepatitis A Virus
Authors: Catherine Chakvetadze, Vincent Mallet, Laure Gaussec, Laurent Hannoun, Stanislas Pol
Journal: Annals of Internal Medicine (2011)

Letters5 April 2011Acute Hepatitis A Virus Infection Without IgM Antibodies to Hepatitis A VirusCatherine Chakvetadze, MD, Vincent Mallet, MD, PhD, Laure Gaussec, MD, Laurent Hannoun, MD, and Stanislas Pol, MD, PhDCatherine Chakvetadze, MDFrom Assistance Publique-Hôpitaux de Paris, Groupe Hospitalier Cochin Saint-Vincent de Paul, 75014 Paris, France; Institut Cochin, Université Paris Descartes, Centre National de la Recherche Scientifique, Institut National de la Santé et de la Recherche Médicale, Assistance Publique-Hôpitaux de Paris, Groupe Hospitalier Cochin Saint-Vincent de Paul, 75014 Paris, France; and Assistance Publique-Hôpitaux de Paris, Groupe Hospitalier Pitié Salpêrière, 75014 Paris, France.Search for more papers by this author, Vincent Mallet, MD, PhDFrom Assistance Publique-Hôpitaux de Paris, Groupe Hospitalier Cochin Saint-Vincent de Paul, 75014 Paris, France; Institut Cochin, Université Paris Descartes, Centre National de la Recherche Scientifique, Institut National de la Santé et de la Recherche Médicale, Assistance Publique-Hôpitaux de Paris, Groupe Hospitalier Cochin Saint-Vincent de Paul, 75014 Paris, France; and Assistance Publique-Hôpitaux de Paris, Groupe Hospitalier Pitié Salpêrière, 75014 Paris, France.Search for more papers by this author, Laure Gaussec, MDFrom Assistance Publique-Hôpitaux de Paris, Groupe Hospitalier Cochin Saint-Vincent de Paul, 75014 Paris, France; Institut Cochin, Université Paris Descartes, Centre National de la Recherche Scientifique, Institut National de la Santé et de la Recherche Médicale, Assistance Publique-Hôpitaux de Paris, Groupe Hospitalier Cochin Saint-Vincent de Paul, 75014 Paris, France; and Assistance Publique-Hôpitaux de Paris, Groupe Hospitalier Pitié Salpêrière, 75014 Paris, France.Search for more papers by this author, Laurent Hannoun, MDFrom Assistance Publique-Hôpitaux de Paris, Groupe Hospitalier Cochin Saint-Vincent de Paul, 75014 Paris, France; Institut Cochin, Université Paris Descartes, Centre National de la Recherche Scientifique, Institut National de la Santé et de la Recherche Médicale, Assistance Publique-Hôpitaux de Paris, Groupe Hospitalier Cochin Saint-Vincent de Paul, 75014 Paris, France; and Assistance Publique-Hôpitaux de Paris, Groupe Hospitalier Pitié Salpêrière, 75014 Paris, France.Search for more papers by this author, and Stanislas Pol, MD, PhDFrom Assistance Publique-Hôpitaux de Paris, Groupe Hospitalier Cochin Saint-Vincent de Paul, 75014 Paris, France; Institut Cochin, Université Paris Descartes, Centre National de la Recherche Scientifique, Institut National de la Santé et de la Recherche Médicale, Assistance Publique-Hôpitaux de Paris, Groupe Hospitalier Cochin Saint-Vincent de Paul, 75014 Paris, France; and Assistance Publique-Hôpitaux de Paris, Groupe Hospitalier Pitié Salpêrière, 75014 Paris, France.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-154-7-201104050-00017 SectionsSupplemental MaterialAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail This article has been corrected. The original version (PDF) is appended to this article as a supplement.Background: Hepatitis A virus (HAV) is the leading cause of acute viral hepatitis in industrialized countries. Diagnosis of acute HAV infection is usually based on detection of anti-HAV IgM antibodies, which are present in more than 99% of affected persons at the onset of illness (1).Objective: To describe a case of acute HAV infection in a patient without anti-HAV IgM antibodies.Case Report: A 32-year-old woman with no history of liver disease was hospitalized for deterioration of liver function. Her medical history ...References1. Lemon SM. Type A viral hepatitis: epidemiology, diagnosis, and prevention. Clin Chem. 1997;43:1494-9. [PMID: 9265900] CrossrefMedlineGoogle Scholar2. de Paula VS, Villar LM, Morais LM, Lewis-Ximenez LL, Niel C, Gaspar AM. Detection of hepatitis A virus RNA in serum during the window period of infection. J Clin Virol. 2004;29:254-9. [PMID: 15018853] CrossrefMedlineGoogle Scholar3. Chamie G, Bonacini M, Bangsberg DR, Stapleton JT, Hall C, Overton ET, et al. Factors associated with seronegative chronic hepatitis C virus infection in HIV infection. Clin Infect Dis. 2007;44:577-83. [PMID: 17243063] CrossrefMedlineGoogle Scholar4. van der Kolk LE, Baars JW, Prins MH, van Oers MH. Rituximab treatment results in impaired secondary humoral immune responsiveness. Blood. 2002;100:2257-9. [PMID: 12200395] CrossrefMedlineGoogle Scholar5. Bingham CO, Looney RJ, Deodhar A, Halsey N, Greenwald M, Codding C, et al. Immunization responses in rheumatoid arthritis patients treated with rituximab: results from a controlled clinical trial. Arthritis Rheum. 2010;62:64-74. [PMID: 20039397] CrossrefMedlineGoogle Scholar Author, Article, and Disclosure InformationAuthors: Catherine Chakvetadze, MD; Vincent Mallet, MD, PhD; Laure Gaussec, MD; Laurent Hannoun, MD; Stanislas Pol, MD, PhDAffiliations: From Assistance Publique-Hôpitaux de Paris, Groupe Hospitalier Cochin Saint-Vincent de Paul, 75014 Paris, France; Institut Cochin, Université Paris Descartes, Centre National de la Recherche Scientifique, Institut National de la Santé et de la Recherche Médicale, Assistance Publique-Hôpitaux de Paris, Groupe Hospitalier Cochin Saint-Vincent de Paul, 75014 Paris, France; and Assistance Publique-Hôpitaux de Paris, Groupe Hospitalier Pitié Salpêrière, 75014 Paris, France.Acknowledgment: The authors thank Anaïs Vallet-Pichard, MD; Hélène Fontaine, MD; Philippe Sogni, MD, PhD; Rachel Jonson, MD;Hélène Brisson, MD; and Anne Marie Roque, MD, PhD.Grant Support: This study did not receive external funding.Disclosures: Dr. Mallet: Board membership: Merck; Consultancy: Gilead Science; Payment for lectures, including service on speakers' bureaus: Roche, Bristol-Myers Squibb, Gilead Science, Merck; Patents (planned, pending, or issued): INSERM.Reproducible Research Statement:Study protocol and statistical code: Not available. Data set: Available from Dr. Mallet (e-mail, vincent.[email protected]aphp.fr) after establishing written agreement with the authors. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoCorrection: Acute Hepatitis A Virus Infection Without IgM Antibodies Metrics Cited bySynthesis of carbon dots with antiphage activity using caffeic acidA novel fluorescence molecularly imprinted sensor for Japanese encephalitis virus detection based on metal organic frameworks and passivation-enhanced selectivityMolecular imprinting resonance light scattering nanoprobes based on pH-responsive metal-organic framework for determination of hepatitis A virusThe serological markers of acute infection with hepatitis A, B, C, D, E and G viruses revisitedManagement of viral hepatitis in patients with haematological malignancy and in patients undergoing haemopoietic stem cell transplantation: recommendations of the 5th European Conference on Infections in Leukaemia (ECIL-5)Hepatobiliary Infections After Solid Organ or Hematopoietic Cell TransplantationSerological markers of autoimmunity in children with hepatitis AWindow period of anti-hepatitis A virus immunoglobulin M antibodies in diagnosing acute hepatitis AMultiple Factors Contribute to Positive Results for Hepatitis A Virus Immunoglobulin M AntibodyCorrection: Acute Hepatitis A Virus Infection Without IgM Antibodies 5 April 2011Volume 154, Issue 7Page: 507-508KeywordsAntibodiesBloodCellsHepatitis A virusImmune responseLiver fibrosisRNAResearch laboratoriesRheumatoid arthritisVaccines ePublished: 5 April 2011 Issue Published: 5 April 2011 Copyright & PermissionsCopyright © 2011 by American College of Physicians. 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