tbuckley/cabot-search huggingface dataset:
Glucocorticoids plus<i>N</i>-Acetylcysteine in Severe Alcoholic Hepatitis
Authors: Eric Nguyen-Khac, Thierry Thevenot, Marie-Astrid Piquet, Saïd Benferhat, Odile Goria, Denis Chatelain, Blaise Tramier, François Dewaele, Salah Ghrib, Marika Rudler, Nicolas Carbonell, Hervé Tossou, Abdeslam Bental, Brigitte Bernard-Chabert, Jean-Louis Dupas
Journal: New England Journal of Medicine (2011)

Mortality among patients with severe acute alcoholic hepatitis is high, even among those treated with glucocorticoids. We investigated whether combination therapy with glucocorticoids plus N-acetylcysteine would improve survival.
Treatment of Raynaud's phenomenon by fibrinolytic enhancement.
Authors: P E Jarrett, M Morland, N L Browse
Journal: BMJ (1978)

Twenty patients with advanced Raynaud's phenomenon, in 14 of whom it was secondary to scleroderma, were treated with stanozolol, an anabolic steroid that enhances natural fibrinolysis. All showed an increase in hand blood flow and a reduction in symptoms during treatment. This response may have been caused by the lysis of fibrin deposited in the digital arteries and the reduction of plasma viscosity. Stanozolol is a useful addition to the treatment of patients with advanced Raynaud's phenomenon who have trophic changes.
Rheumatoid and LE Factors and Their Significance.
Authors: Morris Ziff
Journal: Annals of Internal Medicine (1964)

s1 February 1964Rheumatoid and LE Factors and Their Significance.Morris Ziff, M.D., F.A.C.P.Morris Ziff, M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-60-2-329_2 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptRheumatoid and lupus erythematosus factors are discussed in relation to their occurrence, their possible antibody nature, their significance with regard to possible auto-immune mechanism, role in pathogenesis, prognosis as well as other aspects of rheumatoid arthritis and lupus erythematosus. Epidemiological studies of the rheumatoid factor are reviewed, and their significance in regard to an underlying immunogenetic defect in the connective tissue disease group will be discussed.... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Dallas, Texas PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 February 1964Volume 60, Issue 2_Part_1Page: 329-329KeywordsConnective tissue diseasesLupus erythematosusPathogenesisRheumatoid arthritis ePublished: 1 December 2008 Issue Published: 1 February 1964 PDF downloadLoading ...
Calcium-Channel Blockers and Breast Cancer
Authors: Patricia F. Coogan
Journal: JAMA Internal Medicine (2013)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Internal Medicine HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Internal Medicine journal
Let Ruth into palliative medicine
Authors: Chi-Keong Ong
Journal: BMJ (2006)

the remainder, 189 (51%) patients could not be approached for practical reasons and 111 (30%) refused to discuss resuscitation.The table shows the reasons why patients could not be approached and the reasons for declining.Of the 74 patients who read the leaflet, 65 (88%) reported having little or no prior knowledge, 70 (95%) understood it, 56 (76%) preferred that resuscitation decisions were discussed with them, and 55 (74%) did not mind discussing resuscitation within 24 hours of admission and overall showed a decline in their anxiety score.
Infectious delivery of a 135-kb LDLR genomic locus leads to regulated complementation of low-density lipoprotein receptor deficiency in human cells
Authors: Richard Wade-Martins, Yoshinaga Saeki, E Antonio Chiocca
Journal: Molecular Therapy (2003)

The ability to deliver efficiently a complete genomic DNA locus to human and rodent cells will likely find widespread application in functional genomic studies and novel gene therapy protocols. In contrast to a cDNA expression cassette, the use of a complete genomic DNA locus delivers a transgene intact with its native promoter, the exons, all the intervening introns, and the regulatory regions. The presence of flanking, noncoding genomic DNA sequences could prove critical for prolonged and appropriate gene expression. We have recently developed a technology for the rapid conversion of bacterial artificial chromosome (BAC) clones into high-capacity herpes simplex virus-based amplicon vectors. Here, we express the human low-density lipoprotein receptor (LDLR), mutated in familial hypercholesterolemia (FH), from a 135-kb BAC insert. The infectious LDLR genomic locus vectors were shown to express at physiologically appropriate levels in three contexts. First, the LDLR locus was expressed appropriately in the ldl−/−a7 Chinese hamster ovary (CHO) cell line immediately following infectious delivery; second, the locus was maintained within a replicating episomal vector and expressed at broadly physiological levels in CHO cells for 3 months following infectious delivery; and third, the locus was efficiently expressed in human fibroblasts derived from FH patients. Finally, we show that the infectious LDLR locus retains classical expression regulation by sterol levels in human cells. This long-term expression and physiological regulation of LDLR prepares the way for in vivo functional studies of infectious delivery of BAC inserts.
α-Lipoic Acid and Insulin Autoimmune Syndrome
Authors: Yoshihiko Ishida, Takeshi Ohara, Yoko Okuno, Tatsuo Ito, Yushi Hirota, Kensuke Furukawa, Kazuhiko Sakaguchi, Wataru Ogawa, Masato Kasuga
Journal: Diabetes Care (2007)

Insulin autoimmune syndrome, a relatively rare cause of hypoglycemia, is characterized by the production of autoantibodies to insulin in individuals who have not previously been injected with this hormone (1). Drug-induced autoimmunity appears to be important in the pathogenesis of this syndrome, given that ∼50% of affected individuals have taken certain drugs, most of which (such as methimazole, α-mercaptopropionyl glycine, or glutathione) contain the sulfydryl group, before its onset (1). We now report a case of insulin autoimmune syndrome likely induced by α-lipoic acid (ALA), a reduced form of which contains the sulfydryl group (2).

A 32-year-old Japanese woman visited Ishida Clinic on 1 June 2005 because of a feeling of weariness before lunch and dinner. This symptom, which first occurred on 23 May 2005, was relieved by ingestion of the meal. The patient had been well until the onset of the preprandial weariness, had never been injected with insulin, and had no family history of metabolic, hormonal, or autoimmune diseases. Her weight was 60 kg and height 155.4 cm.

The patient's plasma glucose levels during a 75-g oral glucose tolerance test (OGTT) (59, 154, 207, and 227 mg/dl at 0, 30, 60, and 120 min after glucose ingestion, respectively) performed on 3 June 2005 were consistent with a diagnosis of diabetes, whereas her A1C level was low (4.5%). Serum …
Twentieth-Century Attitudes toward Health and Their Effect on Medicine
Authors: E. Gartly Jaco
Journal: New England Journal of Medicine (1963)

AMERICANS today are spending more, using more and apparently expecting more from their physicians, their hospitals and their clinics than ever before in history. The increased demand by the American public for medical care in general has affected every phase of the entire health and medical-care complex, as indicated by the following trends: gradual rise in the proportion of total income spent on medical care; more prepayment coverage for health care in an increasing variety of plans; demand for more health information by the general public and from more informed sources in addition to attending physicians; the growth of group . . .
Factors affecting the binding of lectins to normal human skin
Authors: CAROLYN M. BELL, CHRISTINE J. SKERROW*
Journal: British Journal of Dermatology (1984)

Factors affecting the binding of a wide range of lectins to normal human skin were examined in order to evaluate current discrepancies in the literature. The profile of specific binding characteristic for each lectin was found to be variously influenced by the source of conjugate, tissue‐processing method, the effectiveness of saccharide inhibitors, and by individual and minor body site variations. Most significantly, the use of routine histological processing not only greatly reduced binding intensity overall but also altered the binding pattern.
Thyroid hormone stimulates NO production via activation of the PI3K/Akt pathway in vascular myocytes
Authors: M. A. Carrillo-Sepulveda, G. S. Ceravolo, Z. B. Fortes, M. H. Carvalho, R. C. Tostes, F. R. Laurindo, R. C. Webb, M. L. M. Barreto-Chaves
Journal: Cardiovascular Research (2009)

Thyroid hormone (TH) rapidly relaxes vascular smooth muscle cells (VSMCs). However, the mechanisms involved in this effect remain unclear. We hypothesize that TH-induced rapid vascular relaxation is mediated by VSMC-derived nitric oxide (NO) production and is associated with the phosphatidylinositol 3-kinase/protein kinase B (PI3K/Akt) signalling pathway.NO levels were determined using a NO-specific fluorescent dye (DAF-2) and nitrite (NO2-) levels. Expression of NO synthase (NOS) isoforms and proteins of the PI3K/Akt pathway was determined by both western blotting and immunocytochemistry. Myosin light chain (MLC) phosphorylation levels were also investigated by western blotting. Exposure of cultured VSMCs from rat thoracic aortas to triiodothyronine (T3) resulted in a significant decrease of MLC phosphorylation levels. T3 also induced a rapid increase in Akt phosphorylation and increased NO production in a dose-dependent manner (0.001-1 microM). VSMCs stimulated with T3 for 30 min showed an increase in the expression of all three NOS isoforms and augmented NO production, effects that were prevented by inhibitors of PI3K. Vascular reactivity studies showed that vessels treated with T3 displayed a decreased response to phenylephrine, which was reversed by NOS inhibition. These data suggest that T3 treatment induces greater generation of NO both in aorta and VSMCs and that this phenomenon is endothelium independent. In addition, these findings show for the first time that the PI3K/Akt signalling pathway is involved in T3-induced NO production by VSMCs, which occurs with expressive participation of inducible and neuronal NOS.Our data strongly indicate that T3 causes NO-dependent rapid relaxation of VSMC and that this effect is mediated by the PI3K/Akt signalling pathway.
Differential prognostic effect of systolic blood pressure on mortality according to left‐ventricular function in patients with acute heart failure
Authors: Julio Núñez, Eduardo Núñez, Gregg C. Fonarow, Juan Sanchis, Vicent Bodí, Vicente Bertomeu‐González, Gema Miñana, Pilar Merlos, Vicente Bertomeu‐Martínez, Josep Redón, Francisco J. Chorro, Angel Llàcer
Journal: European Journal of Heart Failure (2009)
The M&amp;M Game
Authors: Marjorie Schulman
Journal: JAMA (2014)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Over the counter treatment for candidiasis.
Authors: S. Mitchell, C. Bradbeer
Journal: BMJ (1992)

tumours -all in children aged over 10 years.Two children died of cardiovascular lesions, and four patients died of pulmonary lymphangiomyomatosis, all of whom were aged over 40.The remaining deaths were from status epilepticus.16 The implication of these findings is that clinicians need to be more aware of the adult complications of tuberous sclerosis, since in its milder forms the condition seems to be more widespread than was once thought.
Formula for a New Foam
Authors: Lance Frazer
Journal: Environmental Health Perspectives (2004)

As the 2010 phaseout date for chlorofluorocarbons draws nearer, materials engineers are working to find replacements for these ozone-depleting chemicals in the production of plastics and other products. One team of engineers is focusing on a combination of two low-cost and environmentally benign substances--supercritical carbon dioxide and clay nanoparticles--to meet these needs. The result is a strong yet lightweight alternative that retains all the beneficial qualities of solid plastic.
Cathepsin-L contributes to cardiac repair and remodelling post-infarction
Authors: Mei Sun, Manyin Chen, Youan Liu, Masahiro Fukuoka, Kim Zhou, Guohua Li, Fayez Dawood, Anthony Gramolini, Peter P. Liu
Journal: Cardiovascular Research (2010)

Cathepsin-L (CTSL) is a member of the lysozomal cysteine protease family, which participates in remodelling of various tissues. Herein, we sought to examine the potential regulation of CTSL in cardiac remodelling post-infarction.Experimental myocardial infarction (MI) was created in CTSL-deficient (Ctsl(-/-)) mice (B6 × FSB/GnEi a/a Ctsl(fs)/J) and wild-type littermates (Ctsl(+/+)) by left coronary artery ligation. At days 3, 7, 14, and 28 post-MI, we monitored survival rate and evaluated cardiac function, morphology, and molecular endpoints of repair and remodelling. Survival was 56% in Ctsl(-/-) mice in contrast to 80% (P < 0.05) in Ctsl(+/+) mice post-MI by day 28. The Ctsl(-/-) mice exhibited greater scar dilatation, wall thinning, and worse cardiac dysfunction when compared with Ctsl(+/+) mice. Cardiac matrix metallopeptidase-9 (MMP-9) activity was also diminished, and c-kit-positive cells, natural killer cells, fibrocytes, and monocytes mobilized to peripheral blood and deposited to the infarcted myocardium were significantly decreased in Ctsl(-/-) mice. Furthermore, the local inflammatory response, and granulocyte-colony stimulating factor, stem cell factor (SCF), and stromal cell-derived factor-1 (SDF-1α) expression, as well as cell proliferation, revascularization, and myofibroblast deposition were significantly decreased in Ctsl(-/-) mice compared with Ctsl(+/+) mice.Our data indicate that CTSL regulates cardiac repair and remodelling post-MI through a mechanism with multiple pathways.
THE INTERRELATIONS OF SERUM LIPIDS IN NORMAL PERSONS 1
Authors: John P. Peters, Evelyn B. Man
Journal: Journal of Clinical Investigation (1943)

All observers (1 to 5) agree that the concentrations of lipid constituents in the serum of nor- mal individuals vary greatly.In fact, the degree of variability is so great that no significance can be attached to a single observation unless it is extremely abnormal.On the other hand, there is evidence that the degree of variability of certain lipid components-for example, cholesterol-in a given normal person, is far more restricted (4 to 7).Furthermore, the relative proportions of certain of the constituents-for example, the ratio of free to total cholesterol-are quite constant, not only in a given individual, but also in the population at large (4, 8).A large series of measurements of serum lipids from normal persons and patients has, therefore, been analyzed, in an effort to discover criteria which may permit more accurate evaluation of such measurements in pathologic or disturbed physiologic states. MATERIAL AND METHODSThe material consists of a large number of measure- ments of lipids in sera, collected during the last 10 years, from normal persons and patients with various diseases.The subjects were all in the postabsorptive state.The clinical material was derived chiefly from the medical and psychiatric services of the New Haven Hospital and Dispensary.The analytical methods of Man, Gildea, Peters, and Bogdanovitch (9 to 13) were employed.In a large proportion of the determinations, cholesterol, total fatty acid, and lipid phosphorus were measured; in a number, however, lipid phosphorus was omitted.In a few in- stances, both free and total cholesterol were determined; and in a still smaller fraction, iodine numbers were also included.For the last, the procedure of Yasuda (14) was employed. CALCULATIONSThroughout the tables and text, the concentration of each component is expressed in terms related to the method of analysis employed: cholesterol in mgm.per cent, lipid phosphorus in mgm.per cent of phosphorus, and
BACKWARD DISLOCATION OF THE CARPAL SEMILUNAR (OS LUNATUM)
Authors: Wilton H. Robinson
Journal: JAMA (1925)

Forward dislocation of the carpal semilunar is a fairly common condition usually caused by an injury involving violent overextension of the hand. Backward dislocation, as shown in the accompanying illustration, is not frequent. The patient fell from a height, June 10, 1924, and as he alighted he flung out his right arm violently to save himself. He is quite positive that the injury did not take place by reason of contact of the hand with the ground. An effort was made within a few minutes after the accident to reduce the apparent displacement, and it was thought that reduction had been effected. Six weeks later, the hand was still disabled; there was slight swelling, bluish discoloration, and a bony prominence over the back of the wrist; flexion of the hand on the arm was possible, but extension was possible only by passive movement; there was considerable pain. The condition disclosed
Chief rabbi rules against donor cards and organ donation after brain stem death
Authors: J. Wise
Journal: BMJ (2011)

The United Kingdom’s chief rabbi, Jonathan Sacks, has issued an edict that carrying donor cards is unacceptable and that the current organ donor system is incompatible with Jewish law.

The ruling comes after years of debate among rabbinical authorities over the definition of death and when an organ may be removed for transplant purposes. The new statement from the chief rabbi and his rabbinical court, the London Beth Din, says that organs may be removed for transplantation only at the point of cardiorespiratory failure, rather than at brain stem death.

The latest figures for 2010 show that 66% of donations came from donors after brain death and 34% from donors after cardiovascular death, NHS Blood and Transplant said.

The BMA warned that …
Expanding Utilization of Intensity-Modulated Radiotherapy for Prostate Cancer: Soaring Costs, Dubious Benefits
Authors: Matthew R. Cooperberg
Journal: JAMA Internal Medicine (2013)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Internal Medicine HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Internal Medicine journal
Small papilla: another risk factor for post-sphincterotomy perforation
Authors: M. Matsushita, K. Uchida, A. Nishio, H. Takakuwa, K. Okazaki
Journal: Endoscopy (2008)

We read with interest the article by García-Cano et al [1] on retroperitoneal perforation caused by precut endoscopic sphincterotomy for biliary access in a patient with a Billroth II gastrectomy. Because of failed standard cannulation, biliary access was gained after needle knife precut sphincterotomy. After the procedure, the presence of a large volume of retroperitoneal air was suspected from plain radiography, and was confirmed by computed tomography (CT). During surgery, only a pinpoint perforation was noted, and tubal drainage without closure of the perforation was done resulting in uneventful recovery. The authors suspected that the precut procedure and the reversed endoscopic view of the papilla in Billroth II anatomy had led to the perforation. We have encountered perforation after a standard endoscopic sphincterotomy in a patient with a small papilla and normal gastric anatomy. Although a large volume of retroperitoneal air was present, conservative management was successful.
Tesco backs minimum price for alcohol to curb excessive drinking
Authors: C. Hicks
Journal: BMJ (2010)

The supermarket chain Tesco has said it would support minimum pricing for alcohol, after a poll of its customers which found that nearly 70% thought excessive drinking was one of the most serious issues facing the country. The new coalition government, however, seems to have dismissed the idea on the grounds that at present it is not “evidence based.”

In an article in the Daily Telegraph (May 21), Tesco’s chief executive Sir Terry Leahy said he welcomed the plan to ban the sale of alcohol below cost, outlined in the coalition government’s five year policy programme.

“I pledge that we will support Government-led action to make this happen across the UK,” he wrote. But he went further by pledging to “support any future discussions on a minimum price for alcohol.”

In a statement the …