tbuckley/cabot-search huggingface dataset:
Abstract 70: Attitudes, Training Experiences and Professional Expectations Among School Teachers Toward Cardiopulmonary Resuscitation Training in Secondary Schools: A National Survey
Authors: Carolina Malta Hansen, Line Zinckernagel, Tine Tjørnhøj-Thomsen, Annette K Ersbøll, Mads Wissenberg, Peter Weeke, Freddy K Lippert, Gunnar Gislason, Lars Køber, Christian Torp-Pedersen, Fredrik Folke
Journal: Circulation (2014)

Introduction:  In 2005, Cardiopulmonary resuscitation (CPR) training became mandatory by the end of Junior High school (8th grade; 14-15 years) in Denmark, as recommended by the American Heart Association. It is unknown whether consistent CPR training has been implemented.   Methods:  Cross-sectional study of all 8th grade homeroom teachers in randomly selected private and public schools (47.9% of all eligible schools). A questionnaire was constructed and pilot tested based on qualitative interviews and the theory of planned behavior and sent to 1382 teachers. Multivariable logistic regression and generalized estimating equation were used to identify factors associated with completed CPR training.   Results:  Of 667 (48.3%) respondents, 25.2% were male and the median age was 43 years. The minority of 8th grade classes had received training in CPR (28.5%; 95% CI, 25.1%-32.1%) or CPR and AED use (10.2%; 95% CI, 8.0%-12.8%) or were planning to complete training by the end of 8th grade (11.4%; 95% CI, 8.7-14.6). While few respondents (14.1%; 95% CI, 11.4%-17.1%) were aware that CPR training is mandatory, the majority supported mandatory training in CPR (88.0%; 95% CI, 85.2%-90.4%) and AED use (78.2%; 95% CI, 74.8%-81.4%). Most respondents felt unprepared to train students in CPR (86.8%; 95% CI, 83.9%-89.3%), and would prefer external instructors undertook training (71.7%; 95% CI, 68.1%-75.1%). The most important correlates of CPR training were knowledge of it being mandatory, presence of a CPR training coordinator and feeling prepared to train students in CPR (Figure 1).   Conclusion:  Despite being mandatory in all Danish schools since 2005, the minority of students has received or will receive CPR training by the end of 8th grade. The main barriers were feeling unprepared to train students in CPR, lack of knowledge that it is mandatory and a CPR training coordinator at the school.
Lichenoid drug eruption to terazosin
Authors: M.J.A. Koh, P.P. Seah, Y.K. Tay, K. Mancer
Journal: British Journal of Dermatology (2007)

Journal Article Lichenoid drug eruption to terazosin Get access M.J.A. Koh, M.J.A. Koh Changi General Hospital – Dermatology, 2 Simei Street 3 529889, Singapore E‐mail: docmark@pacific.net.sg Search for other works by this author on: Oxford Academic Google Scholar P.P. Seah, P.P. Seah Changi General Hospital – Dermatology, 2 Simei Street 3 529889, Singapore E‐mail: docmark@pacific.net.sg Search for other works by this author on: Oxford Academic Google Scholar Y.K. Tay, Y.K. Tay Changi General Hospital – Dermatology, 2 Simei Street 3 529889, Singapore E‐mail: docmark@pacific.net.sg Search for other works by this author on: Oxford Academic Google Scholar K. Mancer K. Mancer Changi General Hospital – Dermatology, 2 Simei Street 3 529889, Singapore E‐mail: docmark@pacific.net.sg Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 158, Issue 2, 1 February 2008, Pages 426–427, https://doi.org/10.1111/j.1365-2133.2007.08331.x Published: 01 February 2008
Complexes of IL-2/anti IL-2 mAb are able to significantly increase expansion and CD25 expression of activated CD8+ T-lymphocytes
Authors: Jakub Tomala, Marek Kovar, Jiri Strohalm, Tomas Etrych, Blanka Rihova
Journal: Clinical Cancer Research (2007)

AACR Centennial Conference: Translational Cancer Medicine-- Nov 4-8, 2007; Singapore

C17 

Application of anti IL-2 mAb in vivo has been until recently understood as a removal of an active IL-2 from the system. However, it has been clearly shown (Boyman, Kovar, 2006) that such treatment is not always functioning as a depleting process. Moreover, such approach augments proliferation of CD8+ cells simply by increasing the biological activity of preexisting IL-2 through formation of immune complexes. According to mAb used, complexes of recombinant IL-2 and mAb show variable effects on certain cell populations, thus by usage of these immunocomplexes boosting or inhibiting immune response could be achieved.    Our objective was to determine the influence of IL-2 immunocomplexes on main anti-tumor population, CD8+ T- lymphocytes and curative potential on different tumor cell lines in vivo.    We have used purified CFSE labeled CD8+ OT-1 cells for adoptive transfer into B6/SLJ congenic mice with appropriate stimulation with peptide (SIINFEKL) and treatment with different forms of IL-2. We have measured clonal expansion, proliferation and expression of surface markers. Furthermore, we have studied prophylactic effect of these complexes, alone or in combination with other cytokines, on various cancer cell lines in vivo. Our findings suggest such approach is very promising and could prove as potent therapeutical tool in treatment of cancer.    Although this approach is very potent and effective, eradicating of large tumors by these immunocomplexes alone seem to be very difficult and ineffective. Thus, we propose to use combined treatment with polymeric HPMA-doxorubicin conjugates (Rihova, 2005), which have been shown previously to possess strong anti-tumor activity. The rationale here is that chemotherapy is able to eradicate most of the tumor cells while immunotherapy can deal with elimination of small proportion of remaining tumor cells, i.e. to treat minimal residual disease (MRD).
To Make the Patient Ready for Anesthesia: Medical Care of the Surgical Patient.
Authors: Leroy D. Vandam
Journal: Annals of Internal Medicine (1981)

REVIEWSwhat the objectives are.It might have been valuable, however, to have stressed the importance of bacteriologic examination of synovial fluid removed at the time of intraarticular corticosteroid therapy in patients with rheumatoid arthritis in whom there are one or two joints with inflammation out of proportion to other involved joints.As an introduction to the general approaches to diag- nosis and treatment of musculoskeletal disorders, this book should be useful and interesting for generail and primary care internal medicine physicians, medical and family practice residents, medical students and primary care nurses.
Familial gastrointestinal stromal tumours with germline mutation of the KIT gene
Authors: Toshirou Nishida, Seiichi Hirota, Masahiko Taniguchi, Koji Hashimoto, Koji Isozaki, Harumi Nakamura, Yuzuru Kanakura, Tomoyuki Tanaka, Arimichi Takabayashi, Hikaru Matsuda, Yukihiko Kitamura
Journal: Nature Genetics (1998)
Thrombolytic Therapy vs Angioplasty in Acute Myocardial InfarctionThrombolytic Therapy vs Angioplasty in Acute Myocardial Infarction
Authors: Aynna Yee, Arash Gabayan, Enrique V. Carbajal
Journal: JAMA (2002)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Ingestion of topical steroid triggering pustular psoriasis?
Authors: S.D. Orpin, J. Hafiji, H.M. Goodyear, A. Salim
Journal: British Journal of Dermatology (2005)

Conflicts of interest: none declared. Sir, A 7‐year‐old girl was admitted as an emergency under the care of the paediatricians, with painful erythroderma, systemic upset and pyrexia of up to 40 °C. She had a history of special educational needs and hyperactive behaviour, and had previously been treated for psoriasis by her general practitioner (GP), although she had not needed to use any topical therapy for 6 months. There was a strong family history of psoriasis, with both her mother and her maternal grandmother affected. Seven days prior to admission she had ingested more than half of a 100‐g tube of clobetasone butyrate (Eumovate®; GlaxoSmithKline, Uxbridge, U.K) belonging to her mother. Forty‐eight hours after this she began to develop redness and scaling initially on the face and subsequently on the lower limbs. When the GP was consulted the following day pustules were noted, and oral flucloxacillin suspension 125 mg four times daily was commenced along with topical Aqueous Cream. Despite these measures the rash became more widespread, resulting in admission.
Mutations in TNFRSF11A, affecting the signal peptide of RANK, cause familial expansile osteolysis
Authors: Anne E. Hughes, Stuart H. Ralston, John Marken, Christine Bell, Heather MacPherson, Richard G.H. Wallace, Wim van Hul, Michael P. Whyte, Kyoshi Nakatsuka, Louis Hovy, Dirk M. Anderson
Journal: Nature Genetics (2000)
Mitral and Tricuspid Annular Velocities in Constrictive Pericarditis and Restrictive Cardiomyopathy
Authors: Joon Hyouk Choi, Jin-Oh Choi, Dong Ryeol Ryu, Sang-Chol Lee, Seung Woo Park, Yeon Hyeon Choe, Jae K. Oh
Journal: JACC. Cardiovascular imaging (2011)
Abstract 4018: Development and analytical validation of a novel real-time multiplex RT-qPCR assay for the simultaneous quantification of ER, PR, HER-2 and EGFR mRNA expression in circulating tumor cells of breast cancer patients
Authors: Areti D. Strati, Evi S. Lianidou
Journal: Cancer Research (2014)

Abstract Introduction: Circulating Tumor Cells (CTCs) represent an important biological link in the spread of breast cancer from primary to metastatic disease. CTCs have already been established as strong predictors of prognosis in patients with metastatic breast cancer. Triple-negative breast cancers have a more aggressive clinical outcome than other forms of breast cancer. The aim of our work was to develop a quantitative real-time multiplex RT-qPCR assay for studying the expression of ER, PR, HER-2 and EGFR in CTC of breast cancer patients. Materials and Methods: A quadruplex quantitative real time RT-qPCR assay for ER, PR, HER-2 and EGFR was developed based on the de novo in-silico design of eight primers and four dual hybridization probes. All primers and probes were designed to avoid cross-reactions and primer dimer formation and to match the assay conditions, such as amplicon sizes, and melting temperatures. The specificity of all primer and hybridization probe sequences was first tested by homology searches in the nucleotide database (NCBI, nucleotide BLAST). Each probe set included a 3′-fluorescein (F) donor probe and a 5′- LC acceptor probe that was different for each gene set: ER at 610nm, PR at 640nm, HER-2 at 670nm, EGFR at 705nm. A color compensation test was performed by using pure dye spectra so that spectral overlap between dyes was corrected. The LightCycler 2.0 platform, (Roche, Diagnostics) was used since it allows detection of six multiple reporter dyes in the same capillary. The assay was designed, so that only 1 μL of cDNA is used and the total reaction volume is 10 μL. Results: The assay sensitivity was evaluated by performing spiking experiments. For this reason known numbers of MCF7 and SKBR-3 cells, as well as external quantification calibrators ranging from 105 copies/μL to 10 copies/μL, were used. The specificity was evaluated by carefully designed cross reaction studies, performed for each gene target in the presence of all other targets. Our assay, under optimized conditions has shown a very high specificity for each analyte. Conclusions: We report for the first time a highly sensitive, specific and reproducible quantitative multiplex real-time RT-qPCR assay for the simultaneous quantification of ER, PR, HER-2 and EGFR. The assay is currently validated in CTC isolated from a large number of breast cancer patients. Citation Format: Areti D. Strati, Evi S. Lianidou. Development and analytical validation of a novel real-time multiplex RT-qPCR assay for the simultaneous quantification of ER, PR, HER-2 and EGFR mRNA expression in circulating tumor cells of breast cancer patients. [abstract]. In: Proceedings of the 105th Annual Meeting of the American Association for Cancer Research; 2014 Apr 5-9; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2014;74(19 Suppl):Abstract nr 4018. doi:10.1158/1538-7445.AM2014-4018
Abstract 3584: Analysis of colorectal intratumoral genetic heterogeneity by high efficiency and rapid deep targeted sequencing
Authors: Erik S. Hopmans, Hojoon Lee, Laura Miotke, Rowza Tur Rumma, Sue Grimes, John M. Bell, Hanlee P. Ji
Journal: Cancer Research (2014)

Abstract Metastasis is the most frequent cause of morbidity and mortality in cancer. Metastatic disease lethality is often the result of cancer progression despite treatment. Therapeutic resistance is seen nearly in all cases of metastatic cancer. Genetic studies relying on deep sequencing have shown that many cancers are genetically heterogeneous as a result of diverse clonal populations with delineating and unique set of mutations. Several studies suggest that resistance mutations are present in tumors before the start of treatment and via evolution, clonal populations expand under therapeutic selection. However, these minor allelic mutations that define clonal populations are not typically detectable with typical sequencing coverage (20-50X) employed in whole genome approaches. Relying on an innovative programmable targeting method that enables us to rapidly configure nearly any region of the human genome and efficiently sequence cancer genomes, we are determining the extent of intratumoral genetic heterogeneity and clonal diversity in colorectal cancer. Our study involves over 120 patients with available clinical data and a subset of matched tumors indicative of tumor progression (e.g. tumor-normal, premalignant-malignant, malignant-metastasis). Via an integrative analysis of TCGA, COSMIC and other genomic data sets of colorectal cancer, we identified the top ranking 53 cancer genes prone to mutation and associated with advanced colorectal cancer by. These top genes are found in known cancer pathways such as the WNT and RAS/RAF pathway and we are analyzing the exons of these genes for mutations, insertions and deletions with a sequencing depth of at least 1000x. Preliminary results have shown that we can readily reach sequencing depths of 7000x with our automated targeting approach and that a minimal sequencing depth of 1000x will enable detection of aberrations present in the sample below 1%. Samples are being analyzed for the overall level of heterogeneity and correlation of clonal mutations to clinical outcome. For optimal personalized treatment of cancer patients, the analysis of intratumoral genetic heterogeneity may be useful in predicting treatment response and metastatic potential of any given primary colorectal cancer. Citation Format: Erik S. Hopmans, Hojoon Lee, Laura Miotke, Rowza Tur Rumma, Sue Grimes, John M. Bell, Hanlee P. Ji. Analysis of colorectal intratumoral genetic heterogeneity by high efficiency and rapid deep targeted sequencing. [abstract]. In: Proceedings of the 105th Annual Meeting of the American Association for Cancer Research; 2014 Apr 5-9; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2014;74(19 Suppl):Abstract nr 3584. doi:10.1158/1538-7445.AM2014-3584
Mucosal AIDS vaccine reduces disease and viral load in gut reservoir and blood after mucosal infection of macaques
Authors: Igor M. Belyakov, Zdenek Hel, Brian Kelsall, Vladimir A. Kuznetsov, Jeffrey D. Ahlers, Janos Nacsa, David I. Watkins, Todd M. Allen, Alessandro Sette, John Altman, Ruth Woodward, Phillip D. Markham, John D. Clements, Genoveffa Franchini, Warren Strober, Jay A. Berzofsky
Journal: Nature Medicine (2001)
How to diagnose restrictive ventilatory defect by spirometry, and reduce the number of lung volumes measurements?
Authors: Stefan Wesolowski, Piotr Boros
Journal: European Respiratory Journal (2011)

Diagnosis of restrictive ventilatory defect by a low FVC on spirometry is not accurate, even in non-obstructive patients. On the other hand TLC measurements are time-consuming and expensive. So it would be convenient to be able to predict or rule out the possibility of restrictive defect by spirometry and reduce the number of unnecessary TLC measurements.   Aim of the study:  We have looked for a FVC value above which reduced TLC is very unlikely, and other FVC value below which it is highly probable.   Material:  Consisted of pulmonary test results obtained from adult patients, who had undergone spirometry and lung volumes measurements at the same visit.   Results:  From the whole 6538 test results, 4898 patients (53.2% females, 46.8% males; mean age 47,5±14,9 years) without airway obstruction were included into analysis. Restrictive ventilatory defect (TLC    Conclusions:  Spirometry allows accurately rule out volume restriction in patients with FVC ≥95% of pred., and predict restrictive defect in patients with FVC
Abstract 19799: The Addition of Galectin-3 Significantly Improves Upon the Ability of Discharge BNP to Predict 60 Day Readmission for Acute Decompensated Heart Failure
Authors: Sangita Sudharshan, Eric Novak, Maximillian Rosario, Mitchell G Scott, Edward M Geltman
Journal: Circulation (2014)

Introduction:  Acute decompensated heart failure (ADHF) is a major reason for repeated hospitalizations. Identifying those patients with HF at risk for readmission is critical so that preventative interventions can be implemented. Biomarkers such as BNP and galectin-3 (Gal-3) assessed at discharge may potentially be useful, though their role in predicting short-term readmission is not well defined in literature.   Methods:  We enrolled and had follow up data for 91 participants admitted to our facility between 4/2013 and 1/2014 with a primary diagnosis of ADHF. Gal-3 and BNP were obtained within 48 hours prior to hospital discharge after management for ADHF. Gal-3 was assessed using a commercially available assay. We compared subjects who were and were not readmitted (re-ad).   Results:  Discharge BNP was found to be a significant predictor of 30 and 60 day readmission [AUC 0.69 (p=0.046), AUC 0.7 (p=0.005) respectively]. The addition of Gal-3 to discharge BNP provided significantly improved prediction of 60 day re-admission. The net reclassification improvement (NRI) was 55.2% (p=0.037). 14% of re-admitted participants were correctly reclassified and 41% of non-readmitted patients were correctly reclassified using this approach. A statistically significant NRI was not found upon examination of 30 day readmission.   Conclusions:  Measurement of both Gal-3 and BNP at hospital discharge provides significant prediction of hospital re-admission within 60 days. When combined, the prediction of re-admission is significantly improved. This data will be useful to help identify those at-risk of re-admission and aid in efficiently implementing appropriate interventions to reduce re-admission rates.
Germ cell defects and hematopoietic hypersensitivity to gamma- interferon in mice with a targeted disruption of the Fanconi anemia C gene
Authors: MA Whitney, G Royle, MJ Low, MA Kelly, MK Axthelm, C Reifsteck, S Olson, RE Braun, MC Heinrich, RK Rathbun, GC Bagby, M Grompe
Journal: Blood (1996)
Appearance of a novel measles G3 strain in multiple European countries within a two month period, 2010
Authors: K E Brown, M N Mulders, F Freymuth, S Santibanez, M M Mosquera, S Cordey, J Beirnes, S Shulga, R Myers, D Featherstone
Journal: Eurosurveillance (2011)

During late 2010, a previously unrecognised strain of measles genotype G3 virus was identified in five different European countries by the World Health Organization Measles and Rubella Laboratory Network. Apart from one, none had a travel history to south-east Asia, the usual source of G3 viruses, although epidemiological links could be established between some of the cases. This case series illustrates the value of genotyping and sequencing in tracking measles infections, and identifying otherwise unrecognised chains of transmission.
From public health to the health of the public
Authors: S. Palmer
Journal: BMJ (1998)

Editorial p 549 Recent advances p 584 Education and debate pp 587-98

“I have … been taken to see the worst parts of the worst towns in England … but never did I see anything which could compare with Merthyr … one of the most strongly marked cases of the evil so frequently observed, of allowing a village to grow into a town, without providing the means of civic organisation. It is the story of laissez-faire carried out to its legitimate conclusion.”1 So said P H Holland writing to the General Board of Health on 15 December 1853. The priority was for clean drinking water and sewage disposal “before the cholera returns.” Holland hoped that the yet to be appointed officer of health would agree, since he believed that “the labour of such (an) officer will do much to remove the ignorance which has permitted such evils to arise, to …