SPONTANEOUS HYPOGLYCEMIA ASSOCIATED WITH FIBROGENIC TUMOR: REPORT OF TWO CASES
Authors: D A SCHOLZ, L B WOOLNER, J T PRIESTLEY
Journal: Annals of Internal Medicine (1957)

Case Reports1 April 1957SPONTANEOUS HYPOGLYCEMIA ASSOCIATED WITH FIBROGENIC TUMOR: REPORT OF TWO CASESDONALD A. SCHOLZ, M.D., LEWIS B. WOOLNER, M.D., JAMES T. PRIESTLEY, M.D.DONALD A. SCHOLZ, M.D.Search for more papers by this author, LEWIS B. WOOLNER, M.D.Search for more papers by this author, JAMES T. PRIESTLEY, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-46-4-796 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe clinical signs and symptoms associated with hypoglycemia are well documented in recent clinical reviews.1-3The common causes of organic hypoglycemia include (1) hyperinsulinism due to a functioning tumor of the pancreatic islet cells, (2) hypofunction of the anterior lobe of the pituitary gland, (3) hypofunction of the adrenal cortex, and (4) hepatic disease. On rare occasions a fibrogenic tumor, which may arise anywhere in the thorax or retroperitoneal region, can be associated with symptoms of hypoglycemia. We have encountered two patients with fibrogenic tumors whose presenting symptoms were due to recurrent hypoglycemia. In one of these cases, surgical removal...Bibliography1. CrainThorn ELGW: Functioning pancreatic islet cell adenomas: a review of the literature and presentation of two new differential tests, Medicine 28: 427-447 (Dec.) 1949. CrossrefMedlineGoogle Scholar2. Howard JE: Differential diagnosis and therapy of spontaneous hypoglycemia, Veterans Admin. Tech. Bull. No. 10-108, 8: 1-19 (Apr. 30) 1955. Google Scholar3. ConnSeltzer JWHS: Spontaneous hypoglycemia, Am. J. Med. 19: 460-478 (Sept.) 1955. CrossrefMedlineGoogle Scholar4. Arkless HA: Coincidence of rhabdomyofibroma of the diaphragm, idiopathic hypoglycemia and retroperitoneal sarcoma, M. Bull. Veterans Admin. 19: 225-229 (Oct.) 1942. Google Scholar5. Hines RE: Hypoglycemia apparently due to retroperitoneal sarcoma, M. Bull. Veterans Admin. 20: 102-105 (July) 1943. Google Scholar6. StaffieriCamesCid JJOJM: Corticoadrenal tumor with hypoglycemic syndrome, goiter, gynecomastia and hepatosplenomegaly, J. Clin. Endocrinol. 9: 255-267 (Mar.) 1949. CrossrefGoogle Scholar7. Doege KW: Fibro-sarcoma of the mediastinum, Ann. Surg. 92: 955-960 (Nov.) 1930. MedlineGoogle Scholar8. Seckel HP: Postmortem hepatic glycogenolysis in hyperinsulinism and glycogen disease, J. Clin. Investigation 18: 723-731 (Nov.) 1939. CrossrefMedlineGoogle Scholar9. SkillernMcCormackHewlettCrile PGLJJSG: Hyperinsulinism due to islet-cell tumors simulating sarcoma: a report of two cases of large tumors composed of round and spindle cells associated with hypoglycemia, Diabetes 3: 133-140 (Mar.-Apr.) 1954. CrossrefMedlineGoogle Scholar10. SilvisSimon RSDS: Marked hypoglycemia associated with nonpancreatic tumors, New England J. Med. 254: 14-17 (Jan. 5) 1956. CrossrefMedlineGoogle Scholar11. BreidahlPriestleyRynearson HDJTEH: Hyperinsulinism: surgical aspects and results, Ann. Surg. 142: 698-706 (Oct.) 1955. CrossrefMedlineGoogle Scholar12. Whipple AO, quoted by Crain and Thorn.1 Google Scholar13. Rosenfeld ED: Peritoneal pseudomyxoma; report of 4 unusual cases, Arch. Path. 48: 255-273 (Sept.) 1949. Google Scholar14. Anderson HB: A tumor of the adrenal gland with fatal hypoglycemia, Am. J. M. Sc. 180: 71-79 (July) 1930. CrossrefGoogle Scholar15. Lawrence CH: Adrenal cortical tumor: a report of four cases, Ann. Int. Med. 11: 936-948 (Dec.) 1937. LinkGoogle Scholar16. BrosterPatterson LRJ: Unusual case of adrenal carcinoma, with note on application of new colour test, Brit. M. J. 1: 781-782 (Apr. 24) 1948. CrossrefMedlineGoogle Scholar17. Mirsky IA: The role of insulinase and insulinase-inhibitors, Metabolism 5: 138-143 (Mar.) 1956. MedlineGoogle Scholar18. Vallance-OwenHurlockPlease JBNW: Plasma-insulin activity in diabetes mellitus, Lancet 2: 583-587 (Sept. 17) 1955. CrossrefGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Rochester, Minnesota*Received for publication October 10, 1956.From the Sections of Medicine, of Surgical Pathology and of Surgery, Mayo Clinic and Mayo Foundation, Rochester, Minnesota.The Mayo Foundation, Rochester, Minnesota, is a part of the Graduate School of the University of Minnesota.Requests for reprints should be addressed to Section of Publications, Mayo Clinic, Rochester, Minnesota.†Referred by Dr. Robert J. Reed, Des Moines, Iowa. 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LENNARD GOLD, M.D., BRUCE I. SHNIDER, M.D.Mesotheliomas and extraovarian thecomas with hypoglycemic and nephrotic syndromesHypoglycemia Associated with Massive Intra-Abdominal Mesothelial-Cell SarcomaSevere Hypoglycemia Secondary to a Nonpancreatic Fibrosarcoma with Insulin Activity 1 April 1957Volume 46, Issue 4Page: 796-807KeywordsCellsGraduate medical educationHyperinsulinemiaHypoglycemiaPancreasPituitary glandSigns and symptomsSurgerySurgical pathologyThorax ePublished: 1 December 2008 Issue Published: 1 April 1957 PDF downloadLoading ...