tbuckley/cabot-search huggingface dataset:
Effects of Novel Retinoic Acid Metabolism Blocking Agent (VN/14-1) on Letrozole-Insensitive Breast Cancer Cells
Authors: Aashvini Belosay, Angela M.H. Brodie, Vincent C.O. Njar
Journal: Cancer Research (2006)

Abstract Aromatase inhibitors are proving to be more effective than tamoxifen for postmenopausal estrogen receptor (ER)-positive breast cancer. However, the inevitable development of resistance to treatment is a concern. We investigated the effects of novel retinoic acid metabolism blocking agent, VN/14-1, in overcoming letrozole resistance in long-term letrozole cultured (LTLC) cells. Compared with MCF-7 cells stably transfected with aromatase (MCF-7Ca), LTLC cells were no longer sensitive to growth inhibition by aromatase inhibitors. The HER-2/phosphorylated mitogen-activated protein kinase (pMAPK) growth factor signaling pathways were activated, and ERα and coactivator amplified in breast cancer 1 (AIB1) were up-regulated ∼3-fold in LTLC cells. VN/14-1 inhibited aromatase activity and growth values of in MCF-7Ca cells with IC50 of 8.5 and 10.5 nmol/L, respectively. In human placental microsomes, aromatase activity was inhibited with IC50 of 8.0 pmol/L. The IC50 in LTLC cells was 0.83 nmol/L, similar to letrozole (IC50, 0.3 nmol/L) in MCF-7Ca cells. LTLC cells were 10-fold more sensitive to growth inhibition by VN/14-1 than MCF-7Ca cells. VN/14-1 treatment effectively down-regulated ERα, AIB1, pMAPK, HER-2, cyclin D1, cyclin-dependent kinase 4 (CDK4), and Bcl2 and up-regulated cytokeratins 8/18, Bad, and Bax. Tumor growth of LTLC cells in ovariectomized nude mice was independent of estrogens but was inhibited by VN/14-1 (20 mg/kg/d; P &amp;lt; 0.002). Decreases in ERα, cyclin D1, CDK4, and pMAPK and up-regulation of cytokeratins, Bad, and Bax with VN/14-1 in tumor samples may be responsible for the efficacy of this compound in inhibiting LTLC cell growth in vitro and in vivo. (Cancer Res 2006; 66(23): 11485-93)
Effect of Digoxin on Right Ventricular Function in Severe Chronic Airflow Obstruction
Authors: PRAVEEN N. MATHUR
Journal: Annals of Internal Medicine (1981)

The effect of digoxin on the right and left ventricular ejection fractions in 15 patients with pulmonary heart disease caused by severe chronic airflow obstruction was studied in a double-blind, randomized, placebo-controlled trial. All patients were ambulatory and had clinical features of right but not left ventricular dysfunction. Equilibrium radionuclide angiography showed reduced right ventricular ejection fraction in all patients and reduced left ventricular ejection fraction in four. After 8 weeks of digoxin treatment, the abnormal left ventricular ejection fractions were normal; right ventricular ejection fractions increased only in those patients who had had abnormal left ventricular ejection fractions. We conclude that in patients with pulmonary heart disease, the right ventricular ejection fraction is abnormal and improves with digoxin treatment only when the left ventricular ejection fraction also is initially abnormal.
Congenital tuberculosis successfully treated.
Authors: D C Gordon-Nesbitt, G Rajan
Journal: BMJ (1973)

long stay wards and hospitals.We fail to use the most effective therapeutic weapons we have-civilized and interesting conditions in which to live and meaningful things to do.We cannot plead a poverty-stricken society but like to think in terms of irresponsible families.There is no evidence ot irresponsible families.3 4We cannot really face the issue of deterrence.The workhouse setup appeared to work in the past only be- cause of the compulsion of the Poor Law, and to expect it to work on a voluntary basis in an affluent society at the end of the 20th century is ludicrous.What Drs.Hodkinson and Jefferys do not appear to recognize is that the "social dehiscence" which they try so hard to avoid, but are not very clear about, has nearly always occurred already.It is the commonest single reason that brings people to hospital.It is a gaping, a bursting open, and not a withering.The metaphor is crucial because on it hangs the validity of their paper.We have two geriatric units side by side in very similar areas but using very differ- ent methods.There is no way of finding out from present statistics what happens to people who pass through hospital except in a very general way.
AIDS, Activism, and the Politics of Health
Authors: R M Wachter
Journal: New England Journal of Medicine (1992)

THE trends toward empowering patients and questioning scientific expertise antedated the epidemic of the acquired immunodeficiency syndrome (AIDS). As early as the late 1960s, observers noted an increase in the involvement of patients and their advocates in health care organization, provision, financing, and research.1 , 2 Moreover, despite their traditional public emphasis on charitable activities, large health organizations like the American Cancer Society have long traditions of political advocacy.3 Nevertheless, the entry of AIDS activists into the health care scene has added a jarring new dimension to what was previously a genteel dialogue between patient advocates and clinicians, researchers, and policy makers. . . .
Examined at Forty
Authors: Steven M. Lewis
Journal: Annals of Internal Medicine (1992)

On Being a Doctor1 September 1992Examined at FortySteven M. Lewis, MDSteven M. Lewis, MDSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-117-5-433 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptI broke the seal on the examination booklet with the eraser end of the #2 lead pencil provided, exactly as instructed by the proctor. The booklet, the pencil, the optical scan answer sheet, and the overly careful instructions had not changed in the 10 years that had elapsed since I last took a national certifying exam. The proctor was even the same Professor of Examinations who had read me these overly explicit instructions 10 and 20 years ago. I opened the booklet, removed the familiar pink optical scan answer sheet, and closed the booklet again. While quietly awaiting further unnecessary...Reference1. Osler W. Internal medicine as a vocation. In: Osler W. Aequinimitas, with Other Addresses to Medical Students, Nurses and Practitioners of Medicine. 3rd ed. Philadelphia: P. Blakiston's Son & Co.; 1932:133-45. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 September 1992Volume 117, Issue 5Page: 433-435 Issue Published: 1 September 1992 PDF DownloadLoading ...
Independent Prognostic Factors in Patients With Metastatic (Stage D2) Prostate Cancer
Authors: Gerald W. Chodak
Journal: JAMA (1991)

The independent prognostic factors affecting survival were assessed in 240 men undergoing treatment for metastatic prostate cancer as part of a randomized clinical trial comparing the gonadotropin releasing hormone analogue Zoladex (goserelin acetate implant) with castration. In a multivariate analysis, the most highly significant predictors were the presence or absence of bone pain, serum testosterone levels, serum alkaline phosphatase levels, and performance status. Patients with all four factors favorable for survival had a 2-year survival rate of 84% as compared with only 8% for patients with none of the four factors favorable for survival. No other factors were significant. A separate analysis of serum testosterone levels revealed that the higher the pretreatment serum testosterone level, the greater the survival rate. Compared with patients with serum testosterone levels less than 6.9 nmol/L, significant differences in survival were observed for patients with serum testosterone levels of 10.4 to 13.9,13.9 to 17.3, and over 17.3 nmol/L. These results have important implications for the design and analysis of future clinical trials of hormone therapy and for counseling patients regarding the short-term prognosis of their disease. (<i>JAMA</i>. 1991;265:618-621)
A Poem in Two Parts
Authors: Allan S. Pirnique
Journal: Annals of Internal Medicine (1997)

Ad Libitum15 June 1997A Poem in Two PartsAllan S. Pirnique, MDAllan S. Pirnique, MDEl Dorado, AR 71730Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-126-12-199706150-00014 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail I. incomplete accountingSum of existencecounted on a small white pagedoes not total all.II. who countsA nine, nine two o twofor seven-hundred eighty-six point five oled to a nine, nine two, two threefor a four ten point nine one; complicatedby a four twenty seven point five; proceedingto a three, three five one, one;all with many nine, nine two three twos and threes(with twenty-fives).He was most thankful for hisnine, nine two three eightso that he could see his grandsonwho was eleven.427.5 −Cardiorespiratory ... Author, Article, and Disclosure InformationAffiliations: El Dorado, AR 71730Corresponding Author: Allan S. Pirnique, MD, 714 West Faulkner, El Dorado, AR 71730. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 15 June 1997Volume 126, Issue 12Page: 998KeywordsCoronary arteriesIschemiaMyocardial infarction ePublished: 15 August 2000 Issue Published: 15 June 1997 Copyright & PermissionsCopyright © 1997 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Obstructive Uropathy Mimicking Volume Depletion
Authors: Leanna M. Hoffman, Wadi N. Suki
Journal: JAMA (1976)

WHEN volume depletion, heart failure, or other salt-retaining states occur, the reabsorption of sodium in the proximal and distal renal tubules is enhanced. 1,2 As a result, the urine is usually hyperosmotic to plasma, with a sodium concentration equal to or less than 10 to 15 mEq/liter. 3 Based on these facts, one laboratory criterion for volume depletion, or other prerenal factors, in the etiogenesis of acute oliguria is a low urinary sodium concentration. 3   The physicians managing two patients with acute urinary tract obstruction and low urinary sodium values were misled by laboratory values to an initial diagnosis of volume depletion.  Report of Cases  Case 1.—  An 82-year-old man who, during December 1970, fell and sustained a comminuted fracture of the left hip. A pin was inserted in the femur several days after the accident. At that time, a Foley catheter was inserted. On Jan 12,1971, the Foley catheter
Abstract 5343: Development of novel anti-CD27 human antibodies with therapeutic potential
Authors: Li-Zhen He, Laura Vitale, Tom O'Neill, Andrea Crocker, Jenifer Widger, Jim Storey, Jeff Weidlick, Yan Zhang, Henry Marsh, Tibor Keler
Journal: Cancer Research (2010)

Abstract The costimulatory molecule CD27 is a member of the tumor necrosis factor (TNF) receptor superfamily, and is constitutively expressed on the majority of mature T cells, memory B cells, and a portion of NK cells. The interaction of CD27 with its ligand CD70 plays key roles in T cell activation, proliferation, survival, maturation of effector capacity and memory; in clonal B cell expansion and germinal center formation; and in NK cell cytolytic activity. Previous reports have shown that antigen-specific CD8+ cytolytic T cell immunity can be augmented through CD27 activation in mice. Of particular relevance is the work by M. J. Glennie et al. demonstrating that an agonistic anti-mouse CD27 mAb given without a DC maturation signal has potent anti-tumor activity through boosting of T cell immunity. To explore the therapeutic potential of this target, a panel of fully human antibodies recognizing human CD27 was generated using human Ig transgenic mice immunized with recombinant human CD27. These human anti-CD27 mAbs showed specific and high affinity binding to CD27 and CD27-expressing lymphoma cells. We generated transgenic mice that express human CD27 (hCD27-Tg) to evaluate the anti-human CD27 mAbs in vivo. The expression profile and regulation of the human CD27 transgene driven by its own promoter were similar to that observed with endogenous mouse CD27. Administration of anti-human CD27 mAbs in combination with ovalbumin greatly enhanced antigen specific T cell responses compared to ovalbumin plus human IgG1 isotype control in the hCD27-Tg mice. The SIINFEKL-specific CD8+ T cell proliferation and activation were detected by pentamer staining and IFNγ ELISPOT analysis. These data support the further development of these novel human anti-CD27 antibodies and we are currently investigating their therapeutic activity using various in vivo tumor models. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 101st Annual Meeting of the American Association for Cancer Research; 2010 Apr 17-21; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2010;70(8 Suppl):Abstract nr 5343.
POCKET-FLAP SCLERECTO-IRIDODIALYSIS IN GLAUCOMA
Authors: CHARLES NELSON SPRATT
Journal: JAMA (1933)

In 1912, I began to do the trephine operation. Since 1925, I<sup>1</sup>have employed a pocket-flap in all operations for cataract or glaucoma. In many of the latter operations, the iris inclusion method was used with sclerectomy. The appearance of the eye with a bleb of subconjunctival pigmentation due to the included iris is not cosmetically desirable, and there is danger of irritation from the incarcerated iris. A case in which panophthalmitis occurred owing to a late infection and the return of pain and tension in several other eyes following iris inclusion led me to adopt a suggestion by Herbert,<sup>2</sup>namely, an iridodialysis. However, instead, of cutting the sphincter as he suggests and pulling the tongues of the iris into the angles of the wound, I have combined iridodialysis with a Lagrange sclerectomy and a pocket-flap. In 1894, de Wecker<sup>3</sup>suggested sclerotomy with iridodialysis instead of iridectomy.
Are Bisphosphonates Associated With an Increased Risk of Atypical Femoral Fractures as a Class?—Reply
Authors: Raphael P. H. Meier, Rene Rizzoli, Robin E. Peter
Journal: JAMA Internal Medicine (2013)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Internal Medicine HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Internal Medicine journal
Influence of ACE‐inhibition and mechanical unloading on the regulation of extracellular matrix proteins in the myocardium of heart transplantation candidates bridged by ventricular assist devices
Authors: Hendrik Milting, Astrid Kassner, Latif Arusoglu, Helmut E. Meyer, Michel Morshuis, Ramona Brendel, Bärbel Klauke, Aly El Banayosy, Reiner Körfer
Journal: European Journal of Heart Failure (2005)
Inflammatory characteristics of platelet activating factor (PAF-acether) in human skin
Authors: C. B. ARCHER, C. P. PAGE, W. PAUL, J. MORLEY, D. M. MACDONALD
Journal: British Journal of Dermatology (1984)

The phospholipid PAF-acether is released from a range of inflammatory cell types and, in experimental animals, has properties appropriate to a mediator of inflammation. We have studied the inflammatory characteristics of intradermally injected PAF-acether in human skin. An early weal and flare response was succeeded, in a proportion of subjects, by an area of late-onset erythema at the site of the resolved weal, reminiscent of the dual response to allergen in sensitized individuals. The time-course and dose-response relationship of the early response has been determined and a synergistic interaction between PAF-acether and prostaglandin E2 established. PAF-acether should therefore be considered as a potential mediator of both acute and persisting inflammation in man.
Prevalence of buried Barrett’s metaplasia in patients before and after radiofrequency ablation
Authors: J. Yuan, J. Hernandez, S. Ratuapli, K. Ruff, G. De Petris, D. Lam-Himlin, G. Burdick, R. Pannala, F. Ramirez, D. Fleischer
Journal: Endoscopy (2012)

<b>Background and study aim:</b> Radiofrequency ablation (RFA) to treat Barrett’s esophagus is increasingly accepted. Description of the etiology, natural history, and prevalence of buried Barrett’s metaplasia (BBM) following RFA is limited, although BBM continues to pose a clinical dilemma. We aimed to assess the prevalence, characteristics, and eradication rate of BBM in patients with both dysplastic and nondysplastic Barrett’s esophagus, treated with RFA and followed over time. <b>Patients and methods:</b> The presence of Barrett’s esophagus, dysplasia, and BBM, before and after RFA, was assessed by two gastrointestinal pathologists in a retrospective chart review of patients who had undergone RFA at our center and had completed appropriate follow-up. <b>Results:</b> We identified 112 patients with completed treatment and no further planned RFA. In 108, no residual Barrett’s esophagus was seen after RFA; 4 patients with persistent Barrett’s tissue underwent surgery. Regarding BBM, 17 /112 patients (15.2 %) had evidence of BBM during evaluation. In 12 /17 (70.5 %) BBM was found during the RFA treatment, with 8 having previously undergone non-RFA therapy and RFA for Barrett’s esophagus and 4 having no previous intervention. In 5 /17 (29.4 %), BBM was seen only after RFA monotherapy. All 17 showed no evidence of BBM at final evaluation and were classified in the complete remission group (108 /112). <b>Conclusion:</b> Both Barrett’s esophagus and BBM were completely eradicated in all patients with long-term follow-up after RFA. Almost half of the patients with BBM had a prior history of non-RFA therapy for Barrett’s esophagus compared with 26 % the non-BBM cohort. All patients with previously identified Barrett’s esophagus and BBM were completely cleared of disease at final follow-up.
A CASE OF VEGETABLE GASTROLITH
Authors: P. S. Hichens, N. B. Odgers
Journal: BMJ (1912)

iART i6 IT2 of August 14th the eyelids were very puffy.There was no albumen in the urine.On August 18th the spots were scaling, but still hard generally; in a few places a little serum escaped, and(i in otlhers pus, evidently due to infection by scratchinig with his.nails.By August 20th the -colour of the rash lhad fadeled conlsiderably, but the papules were still hard and shotty.The general healtlh of the patient was better; he was ainxtious to get back to hiis home as his wife had been confined whilst he was in hospital; he left for Canton this day.I heard from his doctor that after a few days' rest at lhome lhe was able to return to his work, aind as he has not seen him since he presumes all is well.This case illustrates the sudden onset of symptoms ivithout any warning.It slhows also the long duration of the rash after all drugs had been stopped, the delirium that accompanied the poisoning, the weakness of the pulse and danger to life if not recognized at once alnd stopped, as illustrated in Dr. Wood's cases in Philadelphia.The case showvs also the possibility of mistaking the hard shotty papules for variola in its later stage, and also shows the inadvisability of anyonie out of reach of skilled medical advice using boric acid rectal injections for dysentery.In this case no boric acid was given by the moutl, and it illustrates the rapidity and ease with whiclh boric acid soltition is absorbed by the bowel.
The risks of screening: data from the Nottingham randomised controlled trial of faecal occult blood screening for colorectal cancer
Authors: M H E Robinson, J D Hardcastle, S M Moss, S S Amar, J O Chamberlain, N C M Armitage, J H Scholefield, C M Mangham
Journal: Gut (1999)

<h3>AIMS</h3> To determine the harm that ensues from faecal occult blood (FOB) screening for colorectal cancer. <h3>METHODS</h3> 150 251 people were randomly allocated either to receive biennial Haemoccult FOB tests (n =75 253) or not to be contacted (n=74 998). Study group patients returning positive tests were offered colonic investigation; 1774 underwent complete investigation of the colon. <h3>RESULTS</h3> There was no significant difference in the stage at presentation of interval versus control group cancers. Survival in the interval cancer group was significantly prolonged compared with the control group. Sensitivity for colonoscopy or flexible sigmoidoscopy and double contrast barium enema (DCBE) was 96.7%. There were no complications of DCBE but seven (0.5%) complications of colonoscopy, of which six required surgical intervention. There were no colonoscopy related deaths. No patients without colorectal cancer died within 30 days of colonic investigation. Five patients died within 30 days of surgery for screen detected colorectal neoplasia and a further two died without having surgery. Six patients died after 30 days but within two years of surgery for screen detected benign adenomas or stage A cancers; in all cases the cause of death was not related to colorectal cancer. <h3>CONCLUSIONS</h3> There was investigation related morbidity but no mortality and little to support overdiagnosis bias. The group returning falsely negative tests had a better outcome compared with the whole control group. There is a negative side to any screening programme but mortality reduction in this and other trials suggests that a national programme of colorectal cancer screening should be given consideration.
Rate of bone loss from lumbar spine in women with distal forearm fracture
Authors: N F A Peel, A G Smith, R A Hannon, R Eastell, None Eastell
Journal: BMJ (1996)

Women who sustain a distal forearm fracture are at increased risk of vertebral osteoporosis, particularly if it occurs before the age of 60.1 The aim of this study was to determine the mechanism for low bone mineral density in the lumbar spine of these women by prospectively evaluating the rate of bone loss from the spine.

From our previous study population,1 we studied 86 (69%) of the women (aged 50-81) who had sustained a distal forearm fracture between six months and three years before baseline and 297 women from an age matched, population based cohort. These women did not differ from those lost to follow up in their age, weight, height, years after menopause, or baseline bone mass of the lumbar spine. We measured bone mineral density by dual energy x ray absorptiometry (Lunar DPX, Lunar Corporation, Madison, WI, USA) at baseline and after two years. We examined the effect of age on bone mineral density by linear regression analysis and compared regression lines by …