tbuckley/cabot-search huggingface dataset:
Magnesium sulphate in pre-eclampsia
Authors: T J. Clark, K. S Khan, P. F W Chien
Journal: BMJ (1998)

Prognosis of symptoms that are medically unexplained Every neurology service should have access to specialist liaison psychiatryEditor-Crimlisk et al's report on the outcome of motor symptoms that were medically unexplained in a cohort first identified at the National Hospital for Nervous Diseases is welcomed by those interested in the psychiatry of physical illness. 1 Slater's work, based on cohorts recruited in the 1950s, overestimated the likelihood of misdiagnosis in modern neurology, 2 and his conclusions have dissuaded psychiatrists from becoming involved in the management of hysteria.O'Brien's editorial on Crimlisk et al's study could have sounded two cautionary notes. 3Firstly, the study was not based on a true inception cohort, and it was recruited from a highly specialised centre.Usually, these factors lead to the finding of a worse prognosis than if only incident cases were included and the sample was less prone to recruitment bias.In this case, however, the bias may have been in the other direction.Patients seen at the National Hospital are likely to have been more exhaustively investigated and observed for longer (either in this episode or before referral) than they would be in most hospitals, so that the chances of misdiagnosis are reduced.We should not generalise the study findings to hospitals where initial assessment may be undertaken with little or no access to specialist neurological opinion or investigations.Secondly, the negative message-that high rates of undetected neurological disease are not seen at follow up-has been allowed to obscure the important positive findings of the study.Even years later, the patients had disabling physical symptoms and substantial psychiatric problems.As in Slater's original study, preventable deaths occurred from suicide and the complications of immobility.Many people were apparently not referred for psychiatric help either at the time of the initial presentation or subsequently.The important conclusion of Crimlisk et al's study must be that every neurology service should have easy access to referral to specialist liaison psychiatry. 4This group of patients, who are difficult to treat, are often resistant to treatment, and have a poor prognosis, may then have a reasonable chance of obtaining appropriate treatment for their primary disorder.
Extracorporeal membrane oxygenation as a bridge to cardiac transplantation in a patient with cardiomyopathy and hemophilia A
Authors: Ravi R. Thiagarajan, Stephen J. Roth, Steven Margossian, Andrew S. Mackie, Ellis J. Neufeld, Peter C. Laussen, Joseph M. Forbess, Elizabeth D. Blume
Journal: Intensive Care Medicine (2003)
A Japanese infant with localized ichthyosis linearis circumflexa on the palms and soles harbouring a compound heterozygous mutation in the SPINK5 gene
Authors: Y. Mizuno, Y. Suga, S. Muramatsu, T. Hasegawa, T. Shimizu, H. Ogawa
Journal: British Journal of Dermatology (2005)

Journal Article A Japanese infant with localized ichthyosis linearis circumflexa on the palms and soles harbouring a compound heterozygous mutation in the SPINK5 gene Get access Y. Mizuno, Y. Mizuno Departments of Dermatology and Paediatrics, Juntendo University School of Medicine, 2‐1‐1 Hongo, Bunkyo‐ku, Tokyo, Japan Search for other works by this author on: Oxford Academic Google Scholar Y. Suga, Y. Suga Departments of Dermatology and Paediatrics, Juntendo University School of Medicine, 2‐1‐1 Hongo, Bunkyo‐ku, Tokyo, Japan Yasushi Suga. E‐mail: ysuga@med.juntendo.ac.jp Search for other works by this author on: Oxford Academic Google Scholar S. Muramatsu, S. Muramatsu Departments of Dermatology and Paediatrics, Juntendo University School of Medicine, 2‐1‐1 Hongo, Bunkyo‐ku, Tokyo, Japan Search for other works by this author on: Oxford Academic Google Scholar T. Hasegawa, T. Hasegawa Departments of Dermatology and Paediatrics, Juntendo University School of Medicine, 2‐1‐1 Hongo, Bunkyo‐ku, Tokyo, Japan Search for other works by this author on: Oxford Academic Google Scholar T. Shimizu, T. Shimizu Departments of Dermatology and Paediatrics, Juntendo University School of Medicine, 2‐1‐1 Hongo, Bunkyo‐ku, Tokyo, Japan Search for other works by this author on: Oxford Academic Google Scholar H. Ogawa H. Ogawa Departments of Dermatology and Paediatrics, Juntendo University School of Medicine, 2‐1‐1 Hongo, Bunkyo‐ku, Tokyo, Japan Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 153, Issue 3, 1 September 2005, Pages 661–663, https://doi.org/10.1111/j.1365-2133.2005.06770.x Published: 01 September 2005 Article history Accepted: 13 March 2005 Published: 01 September 2005
Former Addicts Face Barriers to Treatment for HCV
Authors: J Stephenson
Journal: JAMA (2001)

MOST INJECTION DRUG USERS, including those who succeed in kicking the habit, are left with a worrisome legacy: infection with hepatitis C virus (HCV). But for a variety of reasons, some former addicts who develop HCV-related liver disease—notably those receiving methadone maintenance therapy (MMT)—are confronted with barriers to getting much-needed treatment for their illness, barriers that sometimes force them to choose between dying of liver disease and risking relapse and a return to abusing drugs. The problem is not a trivial one. More than any other group of individuals in the United States, injection drug users are likely to acquire the infection. According to the National Center for Infectious Diseases, half or more of all HCV infections are associated with illegal drug use and injection drug users typically become infected with stunning swiftness. Despite the HCV burden in this group, physicians say that patients receiving MMT—including individuals who haven’t injected drugs for many years—are all too frequently turned away for medical treatment for HCV or liver transplantation for HCV-related end-stage liver disease, excluded solely because of their medically approved use of methadone. There are some legitimate concerns about the potential adverse effects of drugs used to treat hepatitis C for patients receiving MMT—including a possible risk of relapse to active drug abuse. But experts agree that these concerns do not mean that patients taking the opioid agonist should be denied access to potentially life-saving HCV treatment.
Fish Oil Supplementation and Arrhythmias—Reply
Authors: Merritt Raitt, William E. Connor, Cynthia Morris, John McAnulty
Journal: JAMA (2005)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Abstract MP73: Leisure Time Physical Activity and Cognitive Decline in the Northern Manhattan Study
Authors: Joshua Z Willey, Hannah Gardener, Sandino Cespedes, Charles DeCarli, Mitsuhiro Yoshita, Yaakov Stern, Ralph L Sacco, Mitchell S Elkind, Clinton B Wright
Journal: Circulation (2015)

Background: Leisure time physical activity (LTPA) has been associated with a lower risk of dementia, but whether the effects are specific to particular cognitive abilities or improvement in functional status remains unclear. We examined LTPA in relation to domain-specific neurocognitive (NC) performance and change over time in a diverse community sample. Methods: Data on LTPA was collected during enrollment (1993-2001) into the Northern Manhattan Study (NOMAS), a prospective cohort study of risk factors for stroke and cognitive decline, using a validated in-person questionnaire, and two waves of NC assessments were done on a subcohort of participants undergoing brain MRI an mean of six and 12 years later (NC1: 2003-2008; NC2: 2008-2014). Baseline LTPA was defined in two manners: (1) maximum intensity of all activities performed categorized as moderate-heavy, light, and none; (2) total summarized as a continuous variable with the metabolic equivalent (MET) score, a composite of total reported intensity and time. Factor analysis-derived construct-relevant cognitive domains, including memory (MEM), executive function (EXEC), processing speed (PS), and language ability (LA), were computed by averaging z-transformed NC test scores. We used multivariable linear regression to examine LTPA in relation to baseline domain-specific NC performance, and change in performance over time, adjusting for socio-demographics, vascular risk factors, and MRI markers of cerebrovascular injury (white matter hyperintensity volume and total cerebral volume, both adjusted for total intracranial volume, and silent brain infarcts). Results: There were 1236 participants (mean age=64 years, 61% women, 67% Latino, 18% black, 15% white) with LTPA and NC data, and 879 with a second NC assessment. Moderate-to-heavy activity was associated with higher baseline LA (p &lt;0.05) and PS (p &lt;0.05), and with a protective effect on change of MEM (p &lt;0.05) and PS (p &lt;0.05); these effects were not attenuated after adjustment for MRI variables. Total MET-score was not associated with baseline NC domain performance. However, participants with greater MET-scores had significantly less decline in processing speed adjusting for age and education. Inclusion of vascular risk factors and MRI markers each attenuated these associations though they remained statistically significant. Conclusions: Leisure time physical activity is independently protective against a decline in processing speed and memory, and was partly mediated by MRI markers. Leisure-time physical activity may protect against dementia through preventing cerebrovascular correlates of brain injury.
Mannose-binding lectin (MBL) polymorphisms in children with post-infectious obliterant bronchiolitis (PIBO)
Authors: Verónica Giubergia, Maximiliano Salim, Fraga Jesica, Castiglioni Nicolas, Sen Luisa, Mangano Andrea, Castaños Claudio
Journal: European Respiratory Journal (2013)

PIBO is a severe disorder following acute lower pulmonary infection in young children. Several agents have been associated with the disease especially adenovirus. MBL deficiency arising from polymorphisms in the coding and non-coding region on the MBL2 gene has been associated with more frequency and severity of respiratory infections.   Objective : To compare frequencies of haplotypes related to MBL insufficiency between children with PIBO and healthy controls, and to evaluate characteristics and evolution of patients with PIBO according to MBL variants.   Methods:  111 children with diagnosis of PIBO were studied (mean age at diagnosis 12 months, rank 1-72). Polymorphisms of MBL2 gene were evaluated. The coding A, B, D and the X promoter variants were assessed by PCR-RFLP. B and D alleles were pooled as O. The combined genotypes A/A and YA/O were grouped as MBL-sufficient ( MBLs ) whereas O/O and XA/O as MBL-insufficient ( MBLi ) groups. The control group included DNA samples from 132 healthy controls from the blood bank of the hospital.   Results: MBLi  was significantly more frequent in PIBO children (n 25, 22.5%) compared to the healthy group (n 17, 12.8%) [p 0.001]. PIBO patients with  MBLi  required intensive care unit [p 0.001] and mechanical assistance at the moment of the viral injury [p 0.001], more frequently than those with MBLs. No differences were observed related to age at diagnosis, gender or mortality.   Conclusions : Polymorphisms resulting in  MBLi  were more common in children with PIBO than in healthy controls. PIBO patients with  MBLi  evidence more severe initial disease.   MBLi  might modify the response against viral infection in young children.
SOD1 rescues cerebral endothelial dysfunction in mice overexpressing amyloid precursor protein
Authors: Costantino Iadecola, Fangyi Zhang, Kiyoshi Niwa, Chris Eckman, Sherry K. Turner, Elizabeth Fischer, Steven Younkin, David R. Borchelt, Karen K. Hsiao, George A. Carlson
Journal: Nature Neuroscience (1999)
Abstract 4088: Isolated Potentials and Pace-Mapping to Guide Ablation for Ventricular Tachycardia in Patients with Non-Ischemic Cardiomyopathy
Authors: Michael Kuhne, Jean-Francois Sarrazin, Darryl Wells, Nagib Chalfoun, Thomas Crawford, Warangkna Boonyapisit, Srikar Veerareddy, Sreedhar Billakanty, Wai Shun Wong, Matthew Ebinger, Eric Good, Aman Chugh, Krit Jongnarangsin, Frank Pelosi, Hakan Oral, Fred Morady, Frank M Bogun
Journal: Circulation (2008)

Background : Isolated potentials (IPs) during sinus rhythm are indicators of fixed scar in patients with prior infarcts. IPs in conjunction with pace-mapping (PM) have been helpful to guide ablation of post-infarction ventricular tachycardia (VT). The purpose of this study was to determine the value of IPs in conjunction with PM to guide VT ablation in patients with non-ischemic cardiomyopathy. Methods : 32 consecutive patients (23 male, age 56±13 years, ejection fraction 0.30±0.14) with VT and non-ischemic cardiomyopathy were analyzed. Thirty/32 patients had an implanted cardioverter defibrillator (ICD). Electroanatomic maps of the left (n=21) and right ventricle (n=13), the coronary sinus (n=3), and the epicardium (n=4) were obtained during baseline rhythm. PM was performed at sites with low voltage (&lt;1.5mV). Radiofrequency energy was delivered at sites with concealed entrainment or matching pace-maps. Mean follow-up time was 10±9 months. Results : 173 VTs (cycle length 359±86 ms) were induced. Appropriate ablation sites with IPs during sinus rhythm were recorded in 19/32 patients (59%) (group A). In these patients, a total of 195 appropriate target sites were identified for 56/100 induced VTs (56%); 136/195 sites (70%) displayed IPs. In the remaining 13 patients, no target sites with IPs were identified (group B) despite combined endocardial and transcutaneous epicardial mapping in 3/13 patients. In these 13 patients, a total of 96 appropriate target sites were identified for 25/73 induced VTs (34%). Fifteen/19 patients (79%) in group A were non-inducible at the end of the procedure compared to 2/13 patients (15%) in group B. During a mean follow-up of 10±9 months, 15/19 patients (79%) in group A compared to 1/13 patients (8%) in group B remained arrhythmia free (p=0.0002). Conclusion : IPs in conjunction with PM are helpful in identifying critical isthmus areas for ablation of VT in patients with non-ischemic cardiomyopathy. Differences in the extent of fixed scar tissue may be the reason for differences in the prevalence of IPs, and this might explain better ablation results in some patients with non-ischemic cardiomyopathy.
Transvalvular left ventricular assistance in cardiogenic shock secondary to acute myocardial infarction
Authors: Richard W. Smalling, Michael Sweeney, Bruce Lachterman, Mary Jane Hess, Randall Morris, H.Vernon Anderson, Jacques Heibig, George Li, James T. Willerson, O.Howard Frazier, Richard K. Wampler
Journal: Journal of the American College of Cardiology (1994)
Cholesterol-Overloaded HDL Particles Are Independently Associated With Progression of Carotid Atherosclerosis in a Cardiovascular Disease-Free Population
Authors: Yue Qi, Jie Fan, Jing Liu, Wei Wang, Miao Wang, Jiayi Sun, Jun Liu, Wuxiang Xie, Fan Zhao, Yan Li, Dong Zhao
Journal: Journal of the American College of Cardiology (2015)
Functional genomics identified a novel protein tyrosine phosphatase receptor type f-mediated growth inhibition in hepatocarcinogenesis
Authors: Rabindranath Bera, Chih-Yung Chiou, Ming-Chin Yu, Jei-Ming Peng, Chung-Ru He, Chih-Yun Hsu, Hsiao-Ling Huang, Uda Y. Ho, Shi-Ming Lin, Yu-Jr Lin, Sen-Yung Hsieh
Journal: Hepatology (2014)

It is unclear how proliferating cells elicit suppression on cell proliferation and how cancer cells evade this growth suppression. Using a loss-of-function screening of the human kinome and phosphatome to identify genes suppressing tumor initiation in human hepatocellular carcinoma (HCC), we identified 19 genes and characterized one of the top-scoring tumor suppressor candidates, protein tyrosine phosphatase receptor type F (PTPRF). We found that PTPRF was induced during cell proliferation by cell-cell contact. Ectopic expression of wild-type PTPRF, but not the phosphatase-inactive mutant, suppressed cell proliferation and colony formation in soft-agar assays. In contrast, PTPRF silencing led to cell hyperproliferation, enhanced tumor colony formation in soft agar, and increased xenograft tumor growth in nude mice. Mechanistically, PTPRF silencing showed aberrant ERK-dependent signaling including the phosphorylation/stabilization of v-myc avian myelocytomatosis viral oncogene homolog (MYC) through the direct activation of v-src avian sarcoma viral oncogene homolog (SRC) and suppression of PP2A. This PTPRF-mediated growth suppression during cell proliferation functioned independently of the Hippo-Yap pathway. Clinically, PTPRF was down-regulated in 42% HCC (37/89), 67% gastric cancer (27/40), and 100% colorectal cancer (40/40). PTPRF up-regulation was found in 24% HCC (21/89) and associated with better clinical outcomes. Conclusion : A novel PTPRF-mediated growth suppression pathway was identified by way of a functional genomics screening in human hepatoma cells. Induction of PTPRF by cell-cell contact during cell proliferation quenched the activated ERK-dependent proliferation signaling to prevent cell hyperproliferation and tumor initiation. PTPRF down-regulation in HCC facilitated tumor development. Our findings shed light on how cancer cells can evade growth suppression and open a new avenue for future development of anticancer therapies. (Hepatology 2014;59:2238–2250)
Mig, the Monokine Induced By Interferon-γ, Promotes Tumor Necrosis In Vivo
Authors: Cecilia Sgadari, Joshua M. Farber, Anne L. Angiolillo, Fang Liao, Julie Teruya-Feldstein, Parris R. Burd, Lei Yao, Ghanshyam Gupta, Chiharu Kanegane, Giovanna Tosato
Journal: Blood (1997)
多关节肿痛-发热-腹痛
Authors: 孙杰, 黄晓明, 曾学军
Journal: BMJ (2008)

患者，女，21岁，因“发热、腹胀2个月，腹痛1周”于2007年12月3日入院。 患者2个月前开始出现间断高热，最高温度超过40℃，伴畏寒、腹胀。1周前腹胀加重，呈全腹持续性胀痛，右下腹为重，与饮食排便无明显关系。伴腹泻，为黄色稀糊状便，次数不多。既往患者有多关节肿痛病史4年，当地诊为类风湿关节炎（RA），不规律使用糖皮质激素和免疫抑制剂如甲氨蝶呤（MTX）、环磷酰胺（CTX）治疗，近2年泼尼松7.5mg每日1次。
Abstract 9902: Serum FGF23 Concentration is Associated With Cardiac Hypertrophy and Decreased Systolic Function Among Both CKD and Non-CKD Cardiac Patients
Authors: Hideaki Morita, Shuichi Fujita, Takahide Ito, Koichi Sohmiya, Masaaki Hoshiga, Nobukazu Ishizaka
Journal: Circulation (2014)

Introduction: Purpose: Serum concentrations of fibroblast growth factor-23 (FGF23) are increased in response to elevated serum phosphate levels among patients with renal dysfunction. Besides regulating circulating phosphate levels, FGF23 may induce cardiac hypertrophy; thus, enhanced FGF23 excretion may underlie the heart failure observed among patients with chronic kidney disease (CKD). Here we examined whether FGF23 concentrations are associated with cardiac hypertrophy among cardiac patients regardless of the presence or absence of CKD. Methods: The present study enrolled 480 cardiac patients admitted to our cardiology department between January 2012 and December 2012. Serum FGF23 level was measured by an ELISA method. Left ventricular mass index (LVMI) was used as a marker of cardiac hypertrophy. Results: Of the 480 patients, 132 (27.5%) had an estimated glomerular filtration rate (eGFR) of &lt;60 mL/min/m2 (no-CKD group) and the remaining 348 (72.5%) had an eGFR of 60 or greater (CKD group). FGF23 was correlated with eGFR in the CKD group, but not in the no-CKD group. Stepwise multivariate linear regression analysis was performed using LVMI as a dependent variable, and sex, age, eGFR, serum calcium and phosphate, and log(FGF23) as independent variables. Log(FGF23) was selected as an independent variable that had a significant association with LVMI with a standardized correlation coefficient of 0.26 in the no-CKD group (P&lt;0.01) and 0.25 in the CKD group (P&lt;0.01). When left ventricular ejection fraction was used as an independent variable in this model, log(FGF23) was selected as significant predictor with a standardized correlation coefficient of -0.20 in the no-CKD group (P&lt;0.05) and -0.18 in the CKD group (P&lt;0.01). Conclusions: Among cardiac patients, serum FGF23 concentration was associated positively with left ventricular mass and negatively with left ventricular ejection fraction not only in patients with CKD, but also in those without CKD.
Genetic Basis for Clinical Response to CTLA-4 Blockade
Authors: Alexandra Snyder, Jedd D Wolchok, Timothy A Chan
Journal: New England Journal of Medicine (2015)

To the Editor: Snyder et al. (Dec.4 issue) 1 state that in patients with melanoma who clinically benefit from blockade of cytotoxic T-lymphocyte antigen 4 (CTLA-4), the tetrapeptide sequences in tumor neoantigens were identical to those in known antigenic peptides in pathogens.The authors probably correctly interpret that this coincidence reflects cross-reactivity between cancer neoepitopes and relevant epitopes from the microbial counterparts.However, another explanation is possible.It could be that there was a positive selection in the thymus for rearranged T-cell receptors (TCRs) that preferentially recognize pathogen-encoded and major histocompatibility complex (MHC)-presented antigenic epitopes.Such a feature could have been sculpted by evolution in TCR variable genes and HLA genes.More information about these interpretations could be gained by knowing the serologic status of the patients with respect to the putatively cross-reacting microbes.For instance, it would be very interesting to ascertain whether the serum samples from patient CR9306 were positive for anti-hepatitis D virus antibodies.Negative serologic status does not completely exclude previous subclinical contact with the infectious agent but would certainly argue against crossreactivity as an explanation for these observations.
Depression, Inflammation, and Incident Cardiovascular Disease in Women With Suspected Coronary Ischemia
Authors: Viola Vaccarino, B. Delia Johnson, David S. Sheps, Steven E. Reis, Sheryl F. Kelsey, Vera Bittner, Thomas Rutledge, Leslee J. Shaw, George Sopko, C. Noel Bairey Merz
Journal: Journal of the American College of Cardiology (2007)