tbuckley/cabot-search huggingface dataset:
Lithium: Proving Its Mettle for 50 Years
Authors: M J Friedrich
Journal: JAMA (1999)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Abstract 14224: Inhibition of Calmodulin Increases Intercellular Coupling of Ventricular Myocardium by Enhancement of Connexin43 Localization in Intercalated Disk.
Authors: Hiroki Takanari, Keiko Miwa, Mayumi Hojo, Haruo Honjo, Tomoko Ohkusa, Itsuo Kodama, Kaichiro Kamiya
Journal: Circulation (2010)
From Hogarth to Rowlandson: Medicine in Art in Eighteenth Century Britain, by Fiona Haslam
Authors: J H Baron
Journal: BMJ (1997)

Fiona Haslam Liverpool University Press, £39.99, pp 336 ISBN 0 85323 640 5

A country of extremes of wealth and poverty, of the educated and the ignorant, where politicians in government and opposition are derided, and where much medical advice is given by alternative practitioners to a gullible population. A land where the poor live many years fewer than the rich, the homeless beg in the streets, and the royal family patronises the alternative sector of health care. An age of “lechery, intoxication, vanity, hypocrisy and lack of compassion,” where “all classes of society, including members of the nobility… impressed by the outward trappings of pseudoscientific knowledge and respectability… were prepared to expose themselves to the dangers associated with quackery.” Alcohol produced “idleness, poverty, misery and distress… …
Perioperative anti-infective prophylaxis with teicoplanin compared to cephalosporins in orthopaedic and vascular surgery involving prosthetic material
Authors: K.Z. Vardakas, E.S. Soteriades, S.A. Chrysanthopoulou, P.J. Papagelopoulos, M.E. Falagas
Journal: Clinical Microbiology and Infection (2005)
Abstract P066: Consumption of a Greater Variety of Healthful Foods is Associated with Metabolic Syndrome and its Components in U.S. Adults
Authors: Maya Vadiveloo, Niyati Parekh, Josiemer Mattei
Journal: Circulation (2014)

Introduction: Consuming a wider variety of nutrient-dense foods may promote adherence to more healthful dietary patterns and enhance metabolic health by improving dietary quality. To examine these associations, we developed the U.S. Healthy Food Diversity (HFD) index to measure dietary variety alongside dietary quality and proportionality. Hypothesis: We assessed the hypothesis that greater diversity within healthful foods would be protective against metabolic syndrome and its components. Methods: A representative sample of non-pregnant, non-lactating adults ages 20+y with two 24-hour recalls and complete fasting biochemical data from the cross-sectional National Health and Nutrition Examination Survey 2003-2006 were selected (n=3,089). Associations between the U.S. HFD, metabolic syndrome, and its components were assessed across U.S. HFD tertiles. The U.S. HFD was generated from dietary recall data and the MyPyramid Equivalent database using a previously validated equation. The index ranges from 0 to nearly 1, with higher scores indicative of more varied diets with a higher proportion healthful food groups. Metabolic syndrome was defined using both the International Diabetes Federation (IDF) and the Adult Treatment Panel (ATP) III criteria based on biochemical parameters, anthropometrics, and self-reported medication. Fasting weights were used to analyze biochemical data and 2-day dietary weights were used in the remaining analyses. Survey-weighted multivariable linear and logistic regression adjusted for demographic factors, smoking, energy, screen time, and leisure activity were used to compute beta coefficients, odds ratios(OR) and 95% confidence intervals(CI). Results: The odds of metabolic syndrome were lowered by nearly 40% in men and women using both the IDF (OR:0.65; 95%CI:0.51-0.83) and ATP III criteria (OR:0.63; 95%CI:0.49-0.80) after multivariable adjustment. Compared to the first tertile, adults in tertile 3 had a lower age- and sex-adjusted odds of impaired fasting glucose (OR:0.79; 95%CI:0.65-0.95) and hypertension (OR:0.81; 95%CI:0.68-0.96). In all models, the odds of reduced HDL and abdominal obesity were 22-33% lower in the highest vs. lowest tertile (p-trend&lt;0.05). Fasting glucose (age- and sex-adjusted), blood pressure, and waist circumference were also lowered across U.S. HFD tertiles following multivariable adjustment in continuous linear regression models. Conclusion: In conclusion, the odds of metabolic syndrome defined using IDF and ATP III criteria were lower across U.S. HFD tertiles and some metabolic parameters improved with greater consumption of a variety of healthful foods. This study provides preliminary evidence that diversity within healthful foods may be protective against metabolic syndrome and highlights the need for future research using longitudinal and experimental study designs.
A phase I trial of the oral cyclin dependent kinase inhibitor CYC202 in patients with advanced malignancy
Authors: J. D. White, J. Cassidy, C. Twelves, C. Benson, S. Pacey, I. Judson, H. McGrath, F. Rose, L. Frenz
Journal: Journal of Clinical Oncology (2004)

3042 Background: CYC202 is an oral cyclin dependent kinase inhibitor of CDKs-2, -7 and -9, leading to inhibition of phosphorylation of CDK substrates, cell cycle arrest, inhibition of transcription and induction of apoptotsis. Preclinical studies show activity in cell lines and xenografts. This trial determines the safety and pharmacokinetics (PK) of CYC202, given b.d. for 7 days q 21. Methods: A starting dose of 200mg/day divided in 2 doses was defined by a single dose trial and preclinical toxicology. CYC202 was given am and pm with the patient fasted 2 hrs before and after. PKs were performed on days 1 and 7 of cycle 1. Dose escalation occurred in the absence of grade ≥3 toxicity to DLT. Results: 21 patients were enrolled (08/01–09/03) median age 62 (39–73 years), 6 F and 15 M, WHO PS 2=2, 1=17 and 0=2. 42 cycles were administered. We have reached 1600mg/day and DLTs seen are grade 3 rash and grade 4 hypokalaemia. Other toxicities include grade 2 elevated creatinine (Cr) (rapidly reversible upon removal of drug) occurring on day 3, grade 3 transaminitis and grade 2 emesis. Due to these observations we expanded the 1600 mg/day cohort + treated 3 patients with additional investigations; EDTA clearance, biochemistry on days 1, 3, 5 and 7, 24 hour urine collections for Cr clearance, urinary electrolytes on days 1 and 7 and urinary retinol binding protein (renal tubular damage) and MAG-3 renograms (renal perfusion) pre-treatment, day 3 and 14. One patient experienced a rapid but reversible increase in Cr and this was associated with reduced renal perfusion at day 3, reverting to baseline by day 14. There were no changes urinary retinol binding proteins. There is a trend to linear increase in AUC with dose (r2 = 0.5). Drug to metabolite ratio (pmf-30–128) =1:1.17. Conclusions: DLTs of hypokalaemia, rash, and a temporary grade 2 increase in Cr were reached at 1600mg/day. The mechanism for this may be an effect on renal perfusion. Author Disclosure Employment or Leadership Consultant or Advisory Stock Ownership Honoraria Research Funding Expert Testimony Other Remuneration Cyclacel Ltd.
Fotoyaşlanmış insan derisinin topikal retinoik asit ile uzun süreli tedavisi epidermal hücre atipisini iyileştirir ve papiller dermisdeki kollajen bandı kalınlaştırır
Authors: Soyun Cho, Lori Lowe, Ted A. Hamilton, Gary J. Fisher, John J. Voorhees veSewon Kang
Journal: Journal of the American Academy of Dermatology (2006)
Mechanisms and Treatment of Obstructive Sleep Apnea—Reply
Authors: Abu S. M. Shamsuzzaman, Bernard J. Gersh, Virend K. Somers
Journal: JAMA (2004)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Amplicon mapping and transcriptional analysis pinpoint cyclin L as a candidate oncogene in head and neck cancer.
Authors: Richard Redon, Thomas Hussenet, Gaétan Bour, Krishna Caulee, Bernard Jost, Danièle Muller, Joseph Abecassis, Stanislas Du Manoir
Journal: Cancer Research (2002)

DNA gains targeting the 3q chromosome are common in head and neck squamous cell carcinomas, as well as in lung, ovarian, and cervical cancer. Several candidate oncogenes located on 3q were proposed, i.e., PIK3CA, p63, and eIF-5A2. However, none of these genes was found included in a narrow high-level amplification. Recently, microarray-based comparative genomic hybridization (array CGH) was developed for high-resolution screening of deletions and amplifications in tumor genomes. In this study, by microarray-based comparative genomic hybridization, we found a narrow 3q25.3 high-level amplification in a head and neck cancer cell line. We precisely delimited the 3-Mb length-amplified segment by semiquantitative PCR and measured the transcriptional level of every gene (RefSeq full-length mRNA) located inside this segment by cDNA microarray and quantitative reverse transcription-PCR. Four genes were overexpressed in three head and neck cancer cell lines with increased DNA copy number, compared with a control tongue cell line. We extended the transcriptional analysis of these four genes to 20 head and neck squamous cell carcinomas. Only one gene, cyclin L (ania-6a), is commonly overexpressed in primary tumors compared with corresponding normal tissues. This cyclin was previously pinpointed as a candidate for a role in promoting cell cycle entry. Thus, we propose cyclin L as a candidate oncogene in head and neck cancer.
Abstract P254: Genome-wide Association and Admixture Study of Iron-related Phenotypes in African Americans
Authors: Jin Li, Leslie A Lange, Qing Duan, Monte S Willis, Yun Li, Herman A Taylor, James G Wilson, Ethan M Lange
Journal: Circulation (2014)

Introduction: Iron deficiency is a heritable risk factor for various serious diseases, including cardiovascular disease (CVD). Genome-wide association studies (GWAS) have identified several variants associated with iron-related phenotypes in individuals of primarily European descent. African Americans (AA) have, on average, greater levels of iron deficiency compared to European Americans, but no large-scale genetic studies for iron-related phenotypes have been performed in individuals of African ancestry to date. Methods: We conducted genome-wide admixture mapping studies and GWASs for serum iron, serum ferritin, transferrin saturation (SAT), and total binding iron capacity (TIBC) in 2347 AA participating in the Jackson Heart Study (JHS). Results: Higher proportions of estimated global African ancestry were significantly associated with lower levels of iron (p=2.4x10 -5 ), SAT (p=0.0019) and TIBC (p=0.042) and a number of chromosomal regions were observed to have local ancestry estimates nominally associated with these measures. We observed significant associations (P &lt; 5x10 -8 ) between serum TIBC levels and multiple independent single nucleotide polymorphisms (SNPs) around TF, a well-established region for iron and transferrin levels in Caucasians, and SNPs near two novel genes: HDGFL1 and MAF. In addition, we replicated four other established loci in our AA samples including SLC17A1 , HFE , HIST1H2BJ and TMPRSS6 . Conclusions: 1) We observed SNPs in or near three genes, TF , HDGFL1 and MAF that were significantly associated with TIBC in AA. 2) We observed that both global and local genetic admixture are important predictors of iron measures in AA, further implicating the importance of certain genetic risk factors in the AA population. 3) We have also replicated four other established loci in our AA samples demonstrating the importance of some genetic risk factors for iron related measure across multiple populations. Future fine-mapping studies, incorporating less common variants, and functional studies should be undertaken to better characterize these loci and to ultimately identify the functional variants directly influencing TIBC levels in AA.
The human body; its structure and operation.
Authors: Isaac Asimov
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Abstract MP68: Risk of Sleep Apnea and Subclinical Cardiovascular Disease in Young-to-Middle Aged Adults: The Bogalusa Heart Study
Authors: TIAN HU, Suzie Bertisch, Wei Chen, Emily Harville, Susan Redline, Lydia Bazzano
Journal: Circulation (2015)

Obstructive sleep apnea (OSA) may affect cardiovascular risk. Prior studies examining this issue have often been limited to patients in clinical settings or older adults. Given the high prevalence of obstructive sleep apnea in middle-aged adults and the influence of duration of OSA on cardiovascular risk, examining subclinical cardiovascular in middle aged-adults would further elucidate the direct relationship between OSA and cardiovascular disease. We examined the association between risk of OSA and subclinical cardiovascular disease indicators among 914 young-to-middle aged adults who responded to the Berlin Questionnaire assessment of OSA risk in 2010, and had measures of carotid intima-media thickness (IMT) and left ventricular (LV) geometry. Carotid IMT was measured using standard procedures and categorized into quartiles. Indices of LV geometry were assessed by M-mode echocardiography and classified into normal, concentric remodeling, eccentric hypertrophy, and concentric hypertrophy by integrating gender and race specific relative wall thickness and LV mass index. High-risk for OSA was determined using Berlin Questionnaire score as the primary outcome. Secondary outcomes included habitual snoring and excessive sleepiness. Of those included in the analysis, mean (SD) age was 43.1 (4.5) yrs; 42.1% were male and 31.7% were Black. A total of 235 (25.7%) participants had elevated Berlin scores indicating high-risk for OSA. Mean (SD) of carotid IMT was 0.66 (0.15) mm, and 87 (9.5%) and 161 (17.6%) participants had eccentric and concentric LV hypertrophy, respectively. In log-linear regression models adjusted for age, race, sex, education, current smoking, regular alcohol consumption, total cholesterol, high-density lipoprotein cholesterol, and type-2 diabetes, participants at high-risk of OSA were 1.35 (95% CI: 1.07 - 1.71) times more likely to be in the highest quartile of IMT (≥0.74 mm), were 1.68 (1.09 - 2.58) times as likely to have concentric hypertrophy, and 1.64 (0.95 - 2.82) times as likely to have eccentric hypertrophy, compared to those at low-risk of OSA. Similar positive associations were observed for habitual snoring but not for excessive sleepiness. After further adjusting for current obesity status in the models, the association of OSA risk with IMT remained consistent while the associations with LV hypertrophy was attenuated. There was no significant effect modification by race or sex. In summary, being at high risk OSA was associated with substantially higher risk of subclinical cardiovascular disease in this biracial, semi-rural, community-based population of young-to-middle age adults.
Abstract 4058: Acid-sensing ion channel 1a (ASIC1a) contributes to cell proliferation and migration caused by acidic environment in human glioma cells
Authors: Mingli Liu, Alyssa (Aihui) Guo, Christopher Ghiathi, Zhigang Xiong
Journal: Cancer Research (2014)

Abstract Due to an increased metabolic rate, an acidic environment is commonly observed in tumor tissues. The acidic environment likely has a significant impact on the viability and proliferation of tumor cells. Acid-sensing ion channel (ASIC)1a is the key proton receptor expressed in nervous systems, which regulates acidosis-induced neuronal injury in various neurological diseases, such as ischemic stroke. Glioblastomamultiforme (GBM) is the most common and aggressive primary brain tumor in adults with median survival time of 14.6 months. Since GBM are characterized by chronic hypoxia and poor perfusion that is likely to result in acidosis, acidosis may influence the growth behavior and response to cytotoxic therapy. In the present study, we examined the effects of acidosis on growth and migration of cultured human malignant glioma cells A172, and the role of ASIC1a in the cell death induced by extracellular acid. Methods: 1) We detected ASIC1a mRNA using reverse-transcription polymerase chain reaction (RT-PCR). 2) We then determined the presence of ASIC1a in A172 cells using electrophysiological recording (patch-clamp technique). 3) We assessed the effects of acidic environment on cell proliferation and maintenance of clonogenic capability using MTT assay and colony formation assay respectively. 4) Finally, we examined the effects of acidic environment on glioma cell migration by transwell invasion assay. Results: 1) RT-PCR detected the presence of ASIC1a and ASIC4 mRNA in A172 cells. 2) The inward current was recorded when treated with pH5.0 solution indicating the expression of functional ASIC1a in A172 cells. 3) Acidic environment decreased the number of surviving A172 cells, the colony formation, and also inhibited A172 cell migration. 4) Inhibition of ASIC currents by nonspecific inhibitor of ASICs amiloride or specific inhibitor PcTX1 protected A172 cell from death. Conclusions: Extracellular acid reduces proliferation and migration in glioma cells. Extracellular acid induces death of glioma cells via ASIC1a mechanisms. These results indicate the presence of ASIC1a in glioma cells and may play significant role in glioma progression. This work was supported by the National Institutes of Health grant numbers NIH R01NS047506, R01NS066027, UL1 RR025008, U54 RR026137, AHA 0840132N, and ALZ IIRG-10-173350. Citation Format: Mingli Liu, Alyssa (Aihui) Guo, Christopher Ghiathi, Zhigang Xiong. Acid-sensing ion channel 1a (ASIC1a) contributes to cell proliferation and migration caused by acidic environment in human glioma cells. [abstract]. In: Proceedings of the 105th Annual Meeting of the American Association for Cancer Research; 2014 Apr 5-9; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2014;74(19 Suppl):Abstract nr 4058. doi:10.1158/1538-7445.AM2014-4058
Crowdsourcing the collateral damage from breast cancer treatment.
Authors: Susan M. Love, Amaka Obidegwu, Christine A Fischetti
Journal: Journal of Clinical Oncology (2014)

110 Background: Survivorship research focuses on quality of life after cancer treatment, but is usually initiated by providers and lacks the voice of the patient. In an effort to explore the patient perspective, we convened a collaboration of advocacy groups to “crowdsource” women’s questions regarding collateral damage from breast cancer treatment. These concerns will be incorporated into the Health of Women [HOW] Study, an ongoing, online cohort study open to anyone aged 18 or older. Methods: Emails to current HOW participants were sent out July 2013 to solicit questions. In October 2013, a new webpage was designed to collect responses; we then partnered with other advocacy organizations and began collecting responses, which were then categorized to guide questionnaire development. Results: Sixteen advocacy organizations came together to support this project. Emails to current HOW participants resulted in 1,191 responses. The website landing page resulted in 5,099 responses. Overall, 16.8% of respondents complained of fatigue, 16.3% of memory problems, 15.7% of anxiety and/or depression, and 14.0% of numbness/neuropathy. Other less frequently reported problems included problems with nail growth, vision, hearing, urinary tract infections, and allergy-like symptoms. Conclusions: We received an overwhelming number of responses about collateral damage. Many of the issues are known side effects, while others are less commonly reported. We will next compare responses to previously validated questionnaires, develop a comprehensive collateral damage questionnaire for inclusion in the HOW Study, and generate a report for publication to be distributed to participants and the medical community.
Glaucoma after pars plana vitrectomy and silicone oil injection for complicated retinal detachments11The authors have no proprietary interest in any of the methods used in this study.
Authors: Santosh G Honavar, Mallika Goyal, Ajit Babu Majji, Pranab Kumar Sen, Thomas Naduvilath, Lalit Dandona
Journal: Ophthalmology (1999)
Science commentary: Skin prick testing
Authors: A. Berger
Journal: BMJ (2002)

Skin prick testing is conventionally used to investigate immediate type hypersensitivity to allergens in patients with rhinoconjunctivitis, contact urticaria, asthma, atopic eczema, and suspected food allergy. It is also a means of detecting allergen specific IgE and has the advantage of being relatively inexpensive, providing immediate results compared with measurement of serum allergen specific IgE by radioallergosorbent testing (RAST).

The technique used for skin prick …