TREATMENT OF SCLERODERMA
Authors: C J ZARAFONETIS
Journal: Annals of Internal Medicine (1959)

Article1 February 1959TREATMENT OF SCLERODERMACHRIS J. D. ZARAFONETIS, M.D., F.A.C.P.CHRIS J. D. ZARAFONETIS, M.D., F.A.C.P.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-50-2-343 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptScleroderma, or diffuse systemic sclerosis, is a challenging disease. Its etiology is not known and its pathogenesis is poorly understood. The clinical and histopathologic features of scleroderma, however, have been repeatedly described1, 2, 3and need be mentioned only briefly here. Characteristically there is cutaneous involvement, usually ushered in by an acute edematous phase, followed by induration and then atrophy. Raynaud's phenomenon may precede, accompany or, rarely, follow the onset of objective skin change. Pain and stiffness of joints, and myalgias are not uncommon. Although the changes in the skin may dominate the clinical picture, it is now well known...Bibliography1. Goetz RH: The pathology of progressive systemic sclerosis (generalized scleroderma) with special reference to changes in the viscera, Clin. Proc. 4: 337-392, 1945. Google Scholar2. LindsayTempletonRothman JRFES: Lesions of the esophagus in generalized progressive scleroderma, J. A. M. A. 123: 745-750, 1943. CrossrefGoogle Scholar3. LeinwandDuryeeRichter IAWMN: Scleroderma (based on a study of over 150 cases), Ann. Int. Med. 41: 1003-1041, 1954. LinkGoogle Scholar4. Zarafonetis CJ: Therapeutic possibilities of para-aminobenzoic acid, Ann. Int. Med. 30: 1188-1211, 1949. LinkGoogle Scholar5. ZarafonetisCurtisGulick CJACAE: Use of para-aminobenzoic acid in dermatomyositis and scleroderma, Arch. Int. Med. 85: 27-43, 1950. CrossrefGoogle Scholar6. Zarafonetis CJ: Clinical use of para-aminobenzoic acid, Texas State J. Med. 49: 666-672, 1953. MedlineGoogle Scholar7. RodmanSchreinerBlack GPGERI: Renal involvement in progressive systemic sclerosis (generalized scleroderma), Am. J. Med. 23: 445-462, 1957. CrossrefMedlineGoogle Scholar8. LorberZarafonetis SHCJ: Esophageal transport studies in patients with scleroderma, to be published. Google Scholar9. Zarafonetis CJ: Treatment of pemphigus with potassium para-aminobenzoate, Am. J. M. Sc. 231: 30-50, 1956. CrossrefMedlineGoogle Scholar10. ZarafonetisLorberHansons CJSHSM: Association of functioning carcinoid syndrome and scleroderma. I. Case report, Am. J. M. Sc. 236: 1-14, 1958. CrossrefMedlineGoogle Scholar11. ZarafonetisKalasWatts CJJPHM: Association of functioning carcinoid syndrome and scleroderma. II. Possible clue to pathogenesis of scleroderma and fibrosis in general, to be published. Google Scholar12. Greiff D: Biology of the Rickettsiae , in The rickettsial diseases of man, 1948, American Association for the Advancement of Science, Washington, D. C., pp. 51-53. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Philadelphia, Pennsylvania*Presented as a Morning Lecture at the Thirty-ninth Annual Session of The American College of Physicians, Atlantic City, New Jersey, April 29, 1958.From the Department of Medicine, Temple University School of Medicine, Philadelphia, Pennsylvania.Requests for reprints should be addressed to Chris J. D. Zarafonetis, M.D., Professor of Clinical and Research Medicine, Temple University Medical Center, Philadelphia 40, Pennsylvania. 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STUMP, M.D.Urinary Indoles and other "Ehrlich's Reagent Reactors" in Rheumatoid ArthritisTreatment of Peyronie's Disease With Potassium Para-Aminobenzoate (potaba) 1 February 1959Volume 50, Issue 2Page: 343-365KeywordsDysphagiaFibrosisMyalgiaPathogenesisRaynaud syndromeRespirationSclerodermaStiffnessSystemic diseasesThorax ePublished: 1 December 2008 Issue Published: 1 February 1959 PDF downloadLoading ...