The Treatment of Pernicious Anemia with a Liver Extract
Authors: Cyrus C. Sturgis, Raphael Isaacs, Millard Smith
Journal: Annals of Internal Medicine (1928)

Article1 June 1928The Treatment of Pernicious Anemia with a Liver ExtractCYRUS C. STURGIS, M.D., RAPHAEL ISAACS, M.D., MILLARD SMITH, M.D.CYRUS C. STURGIS, M.D.Search for more papers by this author, RAPHAEL ISAACS, M.D.Search for more papers by this author, MILLARD SMITH, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-1-12-983 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe discovery by Minot and Murphy (1) (2) that the feeding of one-half pound of mammalian liver daily to patients with uncomplicated pernicious anemia, will cause the red blood count to return to normal limits within six to eight weeks, has received repeated confirmation by numerous investigators. (3) Coincident with the changes in the blood, there is a striking improvement in the patient's general condition and strength. In general, it may be said that all of the symptoms which are directly due to the anemia itself, disappear within approximately two months after the liver treatment is instituted. Having demonstrated that...Bibliography(1) MINOTMURPHY GRWP: Treatment of Pernicious Anemia by Special Diet, J. A. M. A., 87: 470 (1926) CrossrefGoogle Scholar(2) MINOTMURPHY GRWP: A Diet Rich in Liver in the Treatment of Pernicious Anemia; J. A. M. A., 89: 759 (1927) CrossrefGoogle Scholar(3) BRILL ICThe following is a partial list of articles dealing with this subject: : Pernicious Anemia; its Dietary Treatment, Northwest Med., 25: 665 (1926) BRILL, I. C.: Specificity of the Minot-Murphy Diet in Pernicious Anemia; J. A. M. A., 89: 1215 (1927) FETTER, W. J.: Pernicious Anemia; Treatment with Liver, Atlantic Med. J., 31: 150 (1927) HUSTON, J.: Further Observations with the Diet Rich in Liver for the Treatment of Pernicious Anemia, Am. J. Med. Sci., 174: 520 (1927) STARR, PAUL, ELLIOTT, C. A., and NADLER, W. H.; Liver Feeding in Pernicious Anemia, M. Clin. N. Amer. 11:147-155 (July, 1927) STARR, PAUL: Results of Liver Feeding in Pernicious Anemia, Am. J. Med. Sci., 175: 312 (March, 1928) WHITBY, L. E. H.: Leucocytic Changes Resulting from the Treatment of Pernicious Anemia with Liver, Lancet, 214: 285 (Feb. 11, 1928) PHILLIPPS, F. A.: Pernicious Anemia Treated with a Liver Diet, Brit. Med. Jour., 1: 93 (Jan. 21, 1928) MUGRAGE, E. H.: Pernicious Anemia and the Minot-Murphy Diet, Colorado Med. 24: 215 (July, 1927) STURGIS, CYRUS C.: Pernicious Anemia, Bull. Wayne Co. Med. Soc., 19: 3 (Dec. 20, 1927) STURGIS, CYRUS C., ISAACS, RAPHAEL, AND SMITH, MILLARD: Calif. and West. Med., 28:467 (Apr. 1928) MCPEAK, E. M. AND NEIGHBORS, D.: South. M. J. Minot-Murphy Diet in Pernicious Anemia, 20:926 (Dec. 1927) Google Scholar(4) COHNMINOTFULTONULRICHSSARGENTWEAREMURPHY EJGRJFHFFCJHWP: The Nature of the Material in Liver Effective in Pernicious Anemia. I., J. Biol. Chem., 74: Proc. lxix, (1927) Google Scholar(5) MINOT GR: Clinical Discussion of the Anemias, Oxford Medicine, 2: 648 (3), Oxford University Press, London. Google Scholar(6) WEST R: On Feeding Certain Liver Constituents in Pernicious Anemia, Proc. Soc. Exper. Biol. and Med., 24: 665 (1927) CrossrefGoogle Scholar(7) MURPHYMONROEFITZ WPRTR: Changes in Composition of Blood in Pernicious Anemia Treated by a Diet Rich in Liver, J. A. M. A., 88: 1211, (April 16, 1927) CrossrefGoogle Scholar(8) PEABODY FW: The Pathology of the Bone Marrow in Pernicious Anemia, Am. Jour. of Pathol., 3, 179 (1927) MedlineGoogle Scholar(9) MEDEARISMINOT DNGR: Studies on Red Blood Cell Diameter. II. In Pernicious Anemia, Before and During Marked Remission, and in Myelogenous Leukemia, Jour. Clin. Invest., 3, 541, (1927) CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Ann Arbor, Michigan*From the Thomas Henry Simpson Memorial Institute for Medical Research, University of Michigan, Ann Arbor, Michigan.†Presented before the American College of Physicians, March 6, 1928, New Orleans, La. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 June 1928Volume 1, Issue 12Page: 983-995KeywordsAnemiaBloodBlood countsLiverPernicious anemia ePublished: 1 December 2008 Issue Published: 1 June 1928 PDF downloadLoading ...