PACHYMENINGITIS APPARENTLY DUE TO PENICILLIN HYPERSENSITIVITY
Authors: L FARMER, F A ECHLIN, W C LOUGHLIN, A S BREAKEY, R DUVOISIN
Journal: Annals of Internal Medicine (1960)

Case Reports1 April 1960PACHYMENINGITIS APPARENTLY DUE TO PENICILLIN HYPERSENSITIVITYLAURENCE FARMER, M.D., FRANCIS A. ECHLIN, M.D., WINIFRED C. LOUGHLIN, M.D., ARNOLD S. BREAKEY, M.D., ROGER DUVOISIN, M.D.LAURENCE FARMER, M.D.Search for more papers by this author, FRANCIS A. ECHLIN, M.D.Search for more papers by this author, WINIFRED C. LOUGHLIN, M.D.Search for more papers by this author, ARNOLD S. BREAKEY, M.D.Search for more papers by this author, ROGER DUVOISIN, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-52-4-910 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptClinical and experimental observations(1-10) have established that protracted allergic reactions to drugs and foreign proteins may result in a variety of inflammatory and necrotizing tissue lesions. Such lesions, due to hypersensitivity to sulfonamides, penicillin, iodine, foreign sera and egg albumin, have been demonstrated mainly in the heart, lungs, kidneys, liver and spleen. In a patient under our observation there developed a marked pachymeningitis of the dura mater over both cerebral hemispheres, and a severe scleritis, apparently the result of an allergic reaction to penicillin.CASE REPORTA 47 year old woman suffering from excruciatingly severe, unrelenting headache was admitted to...Bibliography1. Rich AR: The role of hypersensitivity in periarteritis nodosa, Bull. Johns Hopkins Hosp. 71: 123, 1942. Google Scholar2. Rich AR: Additional evidence of the role of hypersensitivity in the etiology of periarteritis nodosa, Bull. Johns Hopkins Hosp. 71: 375, 1942. Google Scholar3. Rich AR: Hypersensitivity to iodine as a cause of periarteritis nodosa, Bull. Johns Hopkins Hosp. 77: 43, 1945. Google Scholar4. RichGregory ARJE: Experimental evidence that lesions with the basic characteristics of rheumatic carditis can result from anaphylactic hypersensitivity, Bull. Johns Hopkins Hosp. 73: 239, 1943. Google Scholar5. GregoryRich JEAR: The experimental production of anaphylactic pulmonary lesions with the basic characteristics of rheumatic pneumonitis, Bull. Johns Hopkins Hosp. 78: 1, 1946. MedlineGoogle Scholar6. FrenchWeiler AJCV: Interstitial myocarditis following the clinical and experimental use of sulfonamide drugs, Am. J. Path. 18: 109, 1942. MedlineGoogle Scholar7. French AJ: Hypersensitivity in the pathogenesis of the histopathologic changes associated with sulfonamide chemotherapy, Am. J. Path. 22: 679, 1946. Google Scholar8. MooreMcMillanDuff RHGCGL: The pathology of sulfonamide allergy in man, Am. J. Path. 22: 703, 1946. Google Scholar9. HawnJaneway CVCA: Histological and serological sequences in experimental hypersensitivity, J. Exper. Med. 85: 571, 1947. CrossrefMedlineGoogle Scholar10. Waugh D: Myocarditis, arteritis and focal hepatic, splenic and renal granulomas due to penicillin sensitivity, Am. J. Path. 28: 437, 1952. MedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: New York, N. Y.*Received for publication October 31, 1958.From the Lenox Hill Hospital, New York, N. Y.Requests for reprints should be addressed to Laurence Farmer, M.D., 993 Park Avenue, New York 28, N. Y. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byNeurological Adverse Effects Attributable to β-Lactam Antibiotics: A Literature ReviewContrast enhanced FLAIR imaging in ibuprofen induced aseptic meningitisDrug-induced aseptic meningitisDrug-Induced Aseptic MeningitisDrug-induced meningitisDrug- and Chemical-Induced Aseptic Meningitis: A Review of the LiteratureDrug-induced aseptic meningitisAseptic meningitis with retinal ischemia due to trimethoprim-sulfamethoxazoleRecurrent Encephalitis due to Trimethoprim IntakeTrimethoprim-sulfamethoxazole-associated aseptic meningitis: Case reports and review of the literatureTrimethoprim Associated Aseptic MeningitisPENICILLIN ALLERGY: A REVIEW OF THE IMMUNOLOGICAL AND CLINICAL ASPECTSInfluence of Penicillin Allergic Reactions on Venereal Disease Control Programmes 1 April 1960Volume 52, Issue 4Page: 910-914KeywordsAllergy and immunologyHypersensitivityLesionsMeningitisPenicillinSpleenSulfonamideTuberculosisUrticariaVision ePublished: 1 December 2008 Issue Published: 1 April 1960 PDF downloadLoading ...