TREATMENT OF ACUTE AND CHRONIC LEAD POISONING WITH DISODIUM CALCIUM VERSENATE
Authors: J F WADE, J F BURNUM
Journal: Annals of Internal Medicine (1955)

Article1 February 1955TREATMENT OF ACUTE AND CHRONIC LEAD POISONING WITH DISODIUM CALCIUM VERSENATEJOHN F. WADE JR., M.D., JOHN F. BURNUM, M.D.JOHN F. WADE JR., M.D.Search for more papers by this author, JOHN F. BURNUM, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-42-2-251 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptUntil recently the treatment of lead intoxication has been generally unsatisfactory. The rapid in vivo breakdown of citrate precludes its usefulness as a lead complexing agent.1BAL is also ineffective, and there are suggestions that the BAL-lead complex may be toxic.2Calcium diets, acidifying agents, disodium hydrogen phosphate and other forms of therapy have met with varying success, but in the main they have not proved to be of predictable worth. The availability of disodium calcium ethylenediamine tetra-acetate†(Ca EDTA), a relatively new metal chelating agent which enhances the urinary excretion of lead, offered for the first time considerable promise...Bibliography1. Kety SS: The lead citrate complex ion and its role in physiology and therapy of lead poisoning, J. Biol. Chem. 142: 181, 1942. CrossrefGoogle Scholar2. RyderCholakKehoe HWJRA: Influence of BAL on lead metabolism, Science 106: 63, 1947. CrossrefMedlineGoogle Scholar3. RubinGignacBessmanBelknap MSSPEL: Enhancement of lead excretion in humans by disodium ethylenediamine tetra-acetate, Science 117: 659, 1953. CrossrefMedlineGoogle Scholar4. KarpinskiRiedersGirsh FEFLS: Calcium disodium versenate in therapy of lead encephalopathy, J. Pediat. 42: 687, 1953. CrossrefMedlineGoogle Scholar5. BeesmanRiedRubin SPHM: Treatment of lead encephalopathy with calcium disodium versenate, M. Ann. District of Columbia 21: 312, 1952. MedlineGoogle Scholar6. 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Single Extraction, Mixed Color Dithizone Method, Jan. 2, 1951. Google Scholar12. ToddSanford JDAH: Watson's test for porphyrins, clinical diagnosis by laboratory methods, 1948, W. B. Saunders Company, Philadelphia, p. 102. Google Scholar13. Foreman H: Personal communication to W. B. Frommeyer, Jr., M.D. Google Scholar14. AubFairhallMinotReznikoff JCLTASP: Lead poisoning, Medicine 4: 4, 1925. CrossrefGoogle Scholar15. Watson CJ: Urinary coproporphyrins in health and disease, Pharmacol. Rev. 27: 478, 1947. Google Scholar16. HardyElkinsRuotoloQuinbyBaker HLHBBPJWH: Use of monocalcium disodium ethylene diamine tetra-acetate in lead poisoning, J. A. M. A. 154: 1171, 1954. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: *Received for publication June 18, 1954.From the Department of Medicine, Medical College of Alabama, Birmingham, Alabama, and the Medical Service, Veterans Administration Hospital, Birmingham, Alabama.†Kindly supplied by Bersworth Chemical Co., Framingham, Massachusetts. 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