tbuckley/cabot-search huggingface dataset:
“BACILLUS MUCOSUS CAPSULATUS” IN INFANTILE DIARRHEA 1
Authors: Dwain N. Walcher
Journal: Journal of Clinical Investigation (1946)

Recently an epidemic of diarrhea occurred in the nursery of a children's home.An organism classified as Bacillius mctllCosuts capsulatuts was pres- ent in large numbers in cultures of the stools of the sick infants.Following convalescence of the patients the organisms were not recovered from the stools.The identity of the bacterium isolated in this epidemic has not been established, but it is definitely one of the mucoid encapsulated bacilli.The epidemic is described because there has been ani increasing tendency to regard such organisms as possible intestinal pathogens 2 and because the correlation between the recovery of the organism and disease was striking.
Allergens in celery and zucchini
Authors: S. Vieths, D. Lüttkopf, J. Reindl, M. D. Anliker, B. Wüthrich, B, K. Ballmer‐Weber
Journal: Allergy (2002)

The aim of this study was to confirm allergy to celery tuber and to zucchini, for the first time, by DBPCFC, and to identify the allergens recognized by IgE from DBPCFC‐positive patients. Therefore, raw vegetables were hidden in a broccoli drink, and a DBPCFC‐procedure was developed that consisted of a spit and swallow protocol, making sure that the procedure was safe for the patients and that reactions strictly localized to the oral cavity as well as systemic reactions could be reproduced by DBPCFC. The allergens in celery and zucchini extract were identified by immunoblot inhibition using allergen extracts, recombinant allergens and purified N‐glycans as inhibitors. Celery allergy was confirmed in 69% (22/32) of subjects with a positive case history. Four subjects with a history of allergic reactions to zucchini had a positive DBPCFC to this vegetable. During DBPCFC, systemic reactions were provoked in 50% (11/22) of the patients to celery, and in 3/4 of the zucchini‐allergic patients. The Bet v 1‐related major celery allergen was detected by IgE of 59% (13/22) of the patients. Cross‐reactive carbohydrate epitopes (CCD) bound IgE of 55% (12/22) of the celery‐allergic patients and in 2/4 of the subjects with zucchini allergy. Profilin was a food allergen in celery in 23% (5/22) and in zucchini in 2/4 of the cases. A zucchini‐specific allergen was detected by IgE from one patient. We conclude that ubiquitous cross‐reactive structures are important in allergy to both, celery and zucchini, and that a specific association to birch pollen allergy exists in allergy to celery (mediated by Api g 1), but not in zucchini allergy.
Cardiovascular Responses of Hyperactive Children to Methylphenidate
Authors: Joyce E. Ballard
Journal: JAMA (1976)

Heart rate, blood pressure, and oxygen consumption were measured in 27 hyperactive children during rest, exercise, and recovery, once taking placebo and again taking methylphenidate hydrochloride. Half were measured first taking the drug and half first taking the placebo. Twenty-three matched controls were also measured twice to test for reproducibility of results. Drug and placebo ECGs were recorded on 12 of the subjects. Oxygen consumption did not change (<i>P</i>=.40), but heart rate (<i>P</i>=.001) and blood pressure (<i>P</i>=.003) increased significantly with methylphenidate therapy. There was a significant correlation between size of dose in milligrams per kilogram and increase in heart rate (.38,<i>P</i>&lt;.05) and blood pressure (.50,<i>P</i>&lt;.05 systolic) (.46,<i>P</i>&lt;.05 diastolic). No evidence of the development of tolerance to these drug effects was found in children who had been taking methylphenidate from two months to more than a year. No ECG changes other than tachycardia were seen. (<i>JAMA</i>236:2870-2874, 1976)
Cost of Medical Care-Reply
Authors: Vernon H. Mark
Journal: JAMA (1977)

Much of the criticism in Dr Robertson's first two paragraphs has been covered in the exchange of letters with Dr Max Bader (238:1361, 1977). Specifically, my statements concerning the cost of Medicaid and other federal programs, unlike Dr Robertson's, were buttressed by references. Dr Robertson, unfortunately, has not substantiated his allegations. Furthermore, his criticism of outpatient care in municipal, state, and federal hospitals, often rendered by the faculty members of medical schools, is unfair and inaccurate. How easy it is for academicians in plush surroundings to cast stones at inadequately compensated physicians laboring in neglected physical plants of municipal and state hospitals. Being one of those physicians who renders care both in a private office and in a municipal hospital clinic, I am aware of the short-comings of both of these settings. In my commentary I suggested that some of the funds currently allotted to Medicaid could be
ACUTE RHEUMATIC HEART DISEASE TREATED WITH STREPTOCOCCUS ANTITOXIN (SCARLET FEVER SERUM
Authors: Joseph H. Barach
Journal: JAMA (1927)

<h3>History.</h3> —Jean C. J., aged 3½ years, referred by Dr. McCaffery of Freeport, Pa., had been taken ill three weeks prior to hospitalization with irregular fever, later occasional delirium and one mild convulsive attack, sweats, definite but not severe mobile arthritis, and myositis. The previous history was negative. <h3>Examination.</h3> —The child was well developed and exceedingly bright, pale, and sensitive to pain. The tonsils were large and acutely inflamed, the tonsillar nodes large and tender. The lungs were normal. The heart was enlarged; there was a mitral murmur. The liver was normal. The spleen was palpable at the costal margin. The abdomen otherwise was normal. The joints of the extremities were slightly swollen but very painful and tender, especially the knees and ankles. <h3>Course of the Disease.</h3> —There was a relapsing fever for six weeks. The eighth week was ushered in with a septic temperature curve
The PTEN and INK4A/ARF tumor suppressors maintain myelolymphoid homeostasis and cooperate to constrain histiocytic sarcoma development in humans
Authors: Daniel R. Carrasco, Tim Fenton, Kumar Sukhdeo, Marina Protopopova, Miriam Enos, Mingjian J. You, Dolores Divicio, Cristina Nogueira, Jayne Stommel, Geraldine S. Pinkus, Christopher Fletcher, Jason L. Hornick, Webster K. Cavenee, Frank B. Furnari, Ronald A. DePinho
Journal: Cancer Cell (2006)
Depot medroxyprogesterone (Depo-Provera) and risk of breast cancer.
Authors: C. Paul, D. C. Skegg, G. F. Spears
Journal: BMJ (1989)

OBJECTIVE--To determine whether use of the injectable contraceptive depot medroxyprogesterone acetate (Depo-Provera) affects the risk of breast cancer in women. DESIGN--A population based case-control study. SETTING--Nationwide community study. SUBJECTS--891 Women aged 25-54 with newly diagnosed breast cancer were compared with 1864 women selected at random from the electoral rolls. INTERVENTION--Women were interviewed by telephone about past use of contraceptives and about possible risk factors for breast cancer. MAIN OUTCOME MEASURE--Relative risk of breast cancer in women who had used medroxyprogesterone. RESULTS--Medroxyprogesterone had been used by 110 patients and 252 controls. Overall, the relative risk of breast cancer associated with any duration of use was 1.0 (95% confidence interval 0.80 to 1.3). In women aged 25-34 the relative risk was 2.0 (1.0 to 3.8). The relative risk was highest in women aged 25-34 who had used the drug for six years or longer, although there were few women in this category. Women who had used it for two years or longer before age 25 had an increased risk of breast cancer (relative risk 4.6; 1.4 to 15.1). CONCLUSION--Despite the lack of an overall association these findings suggest that medroxyprogesterone may increase the risk of breast cancer in young women.
Selectivity in Beta-Adrenergic Responses
Authors: ROBERT J. LEFKOWITZ
Journal: Circulation (1974)

THE CONCEPT of drug receptors and of selectivity in drug action is of fundamental importance both to clinicians as they select agents for specific therapeutic problems and for researchers investigating the molecular basis of drug action.Receptors are those cellular structures with which drugs or hormones initially interact.They perform two crucial functions.First, they recognize or discriminate certain biologically active molecules, e.g., adrenergic receptors bind catecholamines, cholinergic receptors bind acetylcholine and related drugs.Second, they transmit a signal which alters certain cellular functions such as enzymes, e.g., adenylate cyclase and ion impermeability of membranes.Thus, receptors determine which drug or drugs will affect a given tissue response-such as cardiac contractility, or rate.The idea of a receptive mechanism for drugs was first clearly described by Langley about 70 years ago.' Adrenergic receptors were first discussed by Dale.2Our current classification of adrenergic receptors into two basic types, a and /3, was originated by Ahlquist some 25 years ago.
Splenic accumulation of IL-10 mRNA in T cells distinct from CD4+CD25+ (Foxp3) regulatory T cells in human visceral leishmaniasis
Authors: Susanne Nylén, Radheshyam Maurya, Liv Eidsmo, Krishna Das Manandhar, Shyam Sundar, David Sacks
Journal: The Journal of Experimental Medicine (2007)

Visceral leishmaniasis (VL) is a life-threatening disease characterized by uncontrolled parasitization of the spleen, liver, and bone marrow. Interleukin (IL)-10 has been implicated in the suppression of host immunity in human VL based on the elevated levels of IL-10 observed in plasma and lesional tissue, and its role in preventing clearance of Leishmania donovani in murine models of VL. The aim of this study was to identify the cellular source of IL-10 in human VL and determine if CD4+CD25+ (Foxp3high) regulatory T (T reg) cells are associated with active disease. We analyzed surface marker and gene expression in peripheral blood mononuclear cells and splenic aspirates from Indian VL patients before and 3–4 wk after treatment with Amphotericin B. The results did not point to an important role for natural CD4+CD25+ (Foxp3high) T reg cells in human VL. They did not accumulate in and were not a major source of IL-10 in the spleen, and their removal did not rescue antigen-specific interferon γ responses. In contrast, splenic T cells depleted of CD25+ cells expressed the highest levels of IL-10 mRNA and were the predominant lymphocyte population in the VL spleen. The elevated levels of IL-10 in VL plasma significantly enhanced the growth of L. donovani amastigotes in human macrophages. The data implicate IL-10–producing CD25−Foxp3− T cells in the pathogenesis of human VL.
NUP98/NSD1 and FLT3/ITD coexpression is more prevalent in younger AML patients and leads to induction failure: a COG and SWOG report
Authors: Fabiana Ostronoff, Megan Othus, Robert B. Gerbing, Michael R. Loken, Susana C. Raimondi, Betsy A. Hirsch, Beverly J. Lange, Stephen Petersdorf, Jerald Radich, Frederick R. Appelbaum, Alan S. Gamis, Todd A. Alonzo, Soheil Meshinchi
Journal: Blood (2014)
An Unusual Presentation of Abdominal Aortic Aneurysm on Static Renal Tc-99m DMSA Scintigraphy
Authors: V Raman, N Kapse, R Karugaba, D G. Sharp, S Stirling, M Hall, Sem Clarke
Journal: Clinical Nuclear Medicine (2007)

The purpose of this report is to describe a case of an unusual presentation of aortic aneurysm on a Tc-99m DMSA scan. A Tc-99m DMSA scan was performed and due to findings seen on the initial views, supplementary larger field of view images were acquired. Assessment of the patient's radiologic imaging was also undertaken. Abnormal accumulation of tracer was seen on the Tc-99m DMSA scan. Supplementary views revealed that this was situated within the abdomen anteriorly, above the bladder. Ultrasound and MRI of the abdomen confirmed that this area corresponded to a large abdominal aortic aneurysm. This case highlights the importance of detailed image evaluation for any ancillary findings, performing supplementary views, and the usefulness of reviewing correlative imaging in arriving at a diagnosis.
TCT-280 Impact of catheter sheath insertion into radial artery on vascular endothelial function as assessed by reactive hyperemia peripheral arterial tonometry
Authors: Tomoo Nakata, Satoshi Ikeda, Seiji Koga, Takeo Yoshida, Miyuki Eto, Yuji Koide, Hiroaki Kawano, Koji Maemura
Journal: Journal of the American College of Cardiology (2013)
P903 CONTROL OF DIABETES MELLITUS (DM) IN LIVER TRANSPLANT RECIPIENTS (LTR)
Authors: B. Rodríguez-Medina, C. Satorres, D. Álvarez, I. Herrero, T. Serrano, M. De la Mata, V. Aguilera, Á. Rubín, M. Berenguer
Journal: Journal of Hepatology (2014)
Radiation Treatment of Pediatric Hepatic Hemangiomatosis and Coexisting Cardiac Failure
Authors: Marvin Rotman, Madhu John, Stephen Stowe, Sarla Inamdar
Journal: New England Journal of Medicine (1980)

Although most pediatric hemangiomas are spontaneously self-involuting tumors,1 a small fraction do not involute and may require drastic therapeutic intervention, as in the invariably fatal syndrome of cutaneous lesions, hepatic hemangiomas, and cardiac failure.2 , 3 We report on a six-month-old child who was treated with a small dose of radiation to less than half the mass of the enlarged liver after she did not respond to conventional therapy and corticosteroids. Dramatic recovery followed, and she is alive three years after treatment and is without evidence of late sequelae.Case ReportThe patient was born after a normal full-term pregnancy. At two . . .
C1-03: A phase III randomised, double blind, placebo controlled trial of gemcitabine/carboplatin with or without thalidomide in advanced non-small cell lung cancer (NSCLC)
Authors: Siow-Ming Lee, Penella J. Woll, Robin M. Rudd, Nicole H. Gower, Christian H. Ottensmeier, Kulsam Ali, Stephen G. Spiro, Allan Hackshaw
Journal: Journal of Thoracic Oncology (2007)
Complication rates of EUS-guided celiac plexus blockade and neurolysis: results of a large case series
Authors: T. O’Toole, N. Schmulewitz
Journal: Endoscopy (2009)

Complication rates for EUS-guided celiac plexus blockade (CPB) and celiac plexus neurolysis (CPN) have been largely derived from studies utilizing percutaneous or surgical techniques, with few studies specifically examining rates for EUS-guided CPB and CPN. This study aims to further describe the complication rates of EUS-guided CPB and CPN.In a retrospective analysis of a prospectively collected EUS database, tracking patients and complications for a single endosonographer at a tertiary-care teaching hospital, data for consecutive patients between August 2003 and March 2008 undergoing either EUS-guided CPB or CPN were analyzed for indications, methods, and complications. Excellent follow-up data were available for all patients.189 EUS-CPB and 31 EUS-CPN procedures were done in 128 and 30 patients, respectively (60 men, 98 women). Indications for blockades included chronic pancreatitis (122), relapsing pancreatitis with chronic pain (28), upper abdominal pain of suspected pancreatic origin (37), and suspected (yet unproven) pancreatic cancer with pain (2). Neurolyses were performed for refractory pain from cancer (21) or chronic pancreatitis (10). No prophylactic antibiotics were administered. Acid suppression was not withheld. Complications were defined as procedural side effects treated with anything beyond standard observation. Four complications were observed during clinical follow-up (three after CPB, one after CPN), giving an overall complication rate of 1.8 % (CPB 1.6 %, CPN 3.2 %). Complications included asymptomatic hypotension after neurolysis, retroperitoneal abscess after CPB, and severe self-limited postprocedural pain in two patients after CPB.EUS-guided CPB and CPN are reasonably safe procedures with tolerable side-effect profiles and low overall complication rates.
Learning Forestry Out of the Lumberyard
Authors: John E. Verby
Journal: JAMA (1981)

Undergraduate clinical training typically involves short-term "rotations" in a tertiary care health center. While such a structure is highly conducive to learning in various specialties, it is particularly limiting to the student's acquisition of the wide array of clinical abilities necessary for primary care. An alternative model is the use of a long-term preceptorship in a primary care setting. This provides training with a more representative patient population and offers a richer clinical experience. An example of this model is a Minnesota program that allows third-year undergraduate medical students to spend nine to 12 months in select primary care settings while receiving ongoing teaching visits from university faculty in major specialty areas. The model can be a legitimate alternative for clinical education of primary care physicians.
Isotretinoin differs from other synthetic retinoids in its modulation of human cellular retinoic acid binding protein (CRABP)
Authors: SUSANNE HIRSCHEL-SCHOLZ, G. SIEGENTHALER, JEAN-HILAIRE SAURAT
Journal: British Journal of Dermatology (1989)

Journal Article Isotretinoin differs from other synthetic retinoids in its modulation of human cellular retinoic acid binding protein (CRABP) Get access SUSANNE HIRSCHEL‐SCHOLZ, SUSANNE HIRSCHEL‐SCHOLZ Clinique de Dermatologie, Hôpital Cantonal Universitaire, 1211 Geneva 4, Switzerland. Search for other works by this author on: Oxford Academic Google Scholar G. SIEGENTHALER, G. SIEGENTHALER Clinique de Dermatologie, Hôpital Cantonal Universitaire, 1211 Geneva 4, Switzerland. Georges Siegnthaler, Clinique de Dermatologie, Hôpital Cantonal Universktakre, 1211 Geneve 4, Switzerland. Search for other works by this author on: Oxford Academic Google Scholar JEAN‐HILAIRE SAURAT JEAN‐HILAIRE SAURAT Clinique de Dermatologie, Hôpital Cantonal Universitaire, 1211 Geneva 4, Switzerland. Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 120, Issue 5, 1 May 1989, Pages 639–644, https://doi.org/10.1111/j.1365-2133.1989.tb01349.x Published: 01 May 1989
Ultrastructural localisation of lactoferrin and glycoprotein in human bronchial glands.
Authors: D Bowes, A E Clark, B Corrin
Journal: Thorax (1981)

The distribution of lactoferrin and glycoprotein in human bronchial glands has been studied by electron microscopy using an immunoperoxidase method to stain the former and a periodic acid-chromic acid-silver methenamine sequence for the latter, each applied to ultrathin Epon sections. The distribution of lactoferrin corresponds to that of lysozyme. Lactoferrin and lysozyme are both confined to serous acini where the granules show a variable pattern of staining. Some serous granules are filled uniformly with lactoferrin, some lack lactoferrin in a small central core or a thin peripheral rim, and some are completely devoid of lactoferrin. Glycoprotein is present in all mucous granules but only certain serous granules. The latter may be filled uniformly with glycoprotein or glycoprotein may form a thin peripheral coat about centrally located lactoferrin and lysozyme. An electron-dense central core found in some serous granules contains neither glycoprotein, lactoferrin, nor lysozyme.
The European Panel on Appropriateness of Gastrointestinal Endoscopy (EPAGE)
Authors: R. Lambert
Journal: Endoscopy (1999)

Gastrointestinal endoscopy has achieved a high standard of accuracy and efficacy in the exploration of the lumen of the digestive tract; this explains the widespread diffusion of the procedure and its major role in the detection and management of digestive diseases, both malignant and nonmalignant. However, its benefits must be weighed against: (i) the variable but generally high costs of the procedure; (ii) the potential risk of complications, and (iii) poor acceptance or tolerance by patients.
The Role of 5-Fluorouracil in Malignant Disease
Authors: B. J. Kennedy, Athanasios Theologides
Journal: Annals of Internal Medicine (1961)

Excerpt The utilization of pyrimidines in the synthesis of nucleic acids has resulted in investigation of their chemical analogs in the chemotherapy of advanced malignancies. A trial of fluorinated pyrimidines in animal tumors was based on the profound biological effect obtained by other compounds when hydrogen was substituted by fluorine. The most potent fluorinated pyrimidine was 5-fluorouracil [Figure 1] (1). Clinical trials in metastatic human cancers have demonstrated objective improvements in a variety of tumors (2-21). The present report is a further evaluation of this agent in an attempt to establish the role of 5-fluorouracil in cancer therapy. BIOCHEMISTRY OF 5-FLUOROURACIL
Target for GPs to diagnose two thirds of dementia cases by April 2015 is likely to be missed
Authors: G. Iacobucci
Journal: BMJ (2015)

<h3>Abstract</h3> Self-grooming is a stereotyped behavior displayed by nearly all animals. Among other established functions, self-grooming is implicated in social communication in some animals. However, whether self-grooming specifically influences behaviors of nearby individuals has not been directly tested, partly due to the technical challenge of inducing self-grooming in a reliable and temporally controllable manner. We recently found that optogenetic activation of dopamine D3 receptor expressing neurons in the ventral striatal islands of Calleja robustly induces orofacial grooming in mice. Using this optogenetic manipulation, here we demonstrate that observer mice display social preference for grooming over non-grooming mice regardless of biological sex. Moreover, grooming-induced social attraction depends on volatile chemosensory cues broadcasted from grooming mice. Collectively, our study establishes self-grooming as a means of promoting social interaction among mice via volatile cues, suggesting an additional benefit for animals to allocate a significant amount of time to this behavior.