THE USE OF FOLIC ACID IN SPRUE
Authors: R M SUAREZ, T D SPIES, R M SUAREZ
Journal: Annals of Internal Medicine (1947)

Article1 May 1947THE USE OF FOLIC ACID IN SPRUERAMÓN M. SUÁREZ, M.D., F.A.C.P., TOM D. SPIES, M.D., F.A.C.P., RAMÓN M. SUÁREZ JR., M.D.RAMÓN M. SUÁREZ, M.D., F.A.C.P.Search for more papers by this author, TOM D. SPIES, M.D., F.A.C.P.Search for more papers by this author, RAMÓN M. SUÁREZ JR., M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-26-5-643 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptA number of investigators have already shown that Addisonian pernicious anemia, non-tropical sprue, and related macrocytic anemias are promptly relieved by the administration of synthetic folic acid (Lactobacillus casei factor).1, 2, 3, 4, 5, 6, 7, 8 Spies and his collaborators from Cincinnati, Birmingham, Cuba and Puerto Rico9, 10, 11 have reported a remarkable effect on persons suffering from tropical sprue. The discovery of the effect of this drug on certain types of macrocytic anemia in relapse opens up a new era in the study of anemia.The University of Cincinnati and the School of Tropical Medicine at San Juan,...Bibliography1. BERRYSPIESDOAN LJTDCA: A note on the influence of "folic acid" on leukocyte equilibrium in malnourished patients, South. Med. Jr., 1945, xxxviii, 590-592. CrossrefGoogle Scholar2. SPIESVILTERKOCHCALDWELL TDCFMBMH: Observations of the anti-anemic properties of synthetic folic acid, South. Med. Jr., 1945, xxxviii, 707-709. CrossrefGoogle Scholar3. VILTERSPIESKOCH CFTDMB: Further studies on folic acid in the treatment of macrocytic anemias, South. Med. Jr., 1945, xxxviii, 781-785. CrossrefGoogle Scholar4. SPIES TD: Treatment of macrocytic anemia with folic acid, Lancet, 1946, i, 225-228. CrossrefGoogle Scholar5. MOOREBIERBAUMWELCHWRIGHT CVOSADLD: The activity of synthetic Lactobacillus casei factor (folic acid) as an antipernicious anemia substance; Observations on four patients: Two with Addisonian pernicious anemia, one with nontropical sprue and one with pernicious anemia of pregnancy, Jr. Lab. and Clin. Med., 1945, xxx, 1056-1069. Google Scholar6. DARBYJONES WJE: Treatment of sprue with synthetic L. casei factor folic acid, vitamin M), Proc. Soc. Exper. Biol. and Med., 1945, lx, 259-262. CrossrefGoogle Scholar7. DARBYJONESJOHNSON WJEHC: The use of synthetic L. casei factor in the treatment of sprue, Science, 1946, ciii, 108. CrossrefGoogle Scholar8. DOANWILSONWRIGHT CAHECS: Folic acid (L. casei factor), essential pan-hematopoietic factor; experimental and clinical studies, Ohio State Med. Jr., 1946, xlii, 139-144. Google Scholar9. SPIESGARCIA-LOPEZMENENDEZMINNICHKOCH TDGJAVMB: The effect of folic acid on sprue, South. Med. Jr., 1946, xxxix, 30-32. CrossrefGoogle Scholar10. SPIESMILANESMENENDEZKOCHMINNICH TDFAMBV: Observations on the treatment of tropical sprue with folic acid, Jr. Lab. and Clin. Med., 1946, xxxi, 227-241. Google Scholar11. SPIESSUAREZSUAREZHERNANDEZ-MORALES TDRMRMF: The therapeutic effect of folic acid in tropical sprue, Science (in press). Google Scholar12. SUAREZ RM: Clinical and hematological review of sprue, Ann. Int. Med., 1938, xii, 529. Google Scholar13. RODRIGUEZ MOLINA R: Sprue in Puerto Rico. A clinical study of one hundred cases, Puerto Rico Jr. Pub. Health and Trop. Med., 1941, xvii, 134. Google Scholar14. RODRIGUEZ-OLLEROS A: The stomach in tropical sprue, Puerto Rico Jr. Pub. Health and Trop. Med., 1938, xiii, 503-521. Google Scholar15. HERNANDEZ-MORALES F: Gastroscopic and pectosigmoidoscopic observations in tropical sprue, Puerto Rico Jr. Pub. Health and Trop. Med., 1944, xx, 257. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: *Presented at the Twenty-Seventh Annual Session of the American College of Physicians, Philadelphia, May 17, 1946.From the School of Tropical Medicine of Puerto Rico and from the University of Cincinnati.In the medical care of the patients we were assisted by Dr. Caroline K. Pratt, Dr. Dwight Santiago-Stevenson and Dr. Federico Hernandez-Morales. The determination of the fat was done by Dr. C. F. Asenjo, the chemical studies by Dr. R. Ruiz Nazario, and the study of the reticulocytes and bone marrow by Miss Clemencia Benitez-Gautier. Nextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byHyposplenism and Gastrointestinal Diseases: Significance and MechanismsHyposplenismAnemia Due to Vitamin B12Deficiency After Treatment with Folic Acid in Tropical SprueHyposplenism in gastrointestinal disease.Defective Splenic Function and its Relation to Bowel DiseaseMalabsorption syndromes in infancy and childhood. Part IILong-Term Follow-Up of Antibiotic-Treated Tropical SprueFREDERICK R. RICKLES, M.D., FREDERICK A. KLIPSTEIN, M.D., F.A.C.P., JUAN TOMASINI, M.D., JOSE J. CORCINO, M.D., NORMAN MALDONADO, M.D., F.A.C.P.Splenic Function in Adult Coeliac DiseaseThe absorption and malabsorption of folic acid and its polyglutamatesADULT CŒLIAC DISEASE IN HYPOSPLENIC PATIENTSTropical Sprue in ChildrenCurrent Views on Tropical Sprue and a Comparison to Nontropical SprueTropical SprueRoentgenographic mucosal patterns in the “malabsorption syndrome“Tropical sprue and intussusception: An unusual associationAppearances of the jejunal mucosa in acute tropical sprue in Singapore.Peroral Biopsy of the Small IntestineThe Gastric Mucosa in Tropical SprueThe structural and functional status of the liver in tropical spruePrognosis of Tropical Sprue A Study of the Effect of Folic Acid on the Intestinal Aspects of Acute and Chronic SprueTHOMAS W. SHEEHY, M.D., F.A.C.P., BARBARA BAGGS, B.S., M.A., ENRIQUE PEREZ-SANTIAGO, M.D., MARTIN H. FLOCH, M.D.Tropical Sprue and Vitamin B 12How Much Folic Acid Is Safe in Pernicious Anemia?Management of Primary Intestinal MalabsorptionTropical SprueJEJUNAL BIOPSIES IN SPRUE*CHARLES E. BUTTERWORTH JR., ENRIQUE PEREZ-SANTIAGO, M.D.Gastrointestinal malabsorptive syndromesClinical studies with the citrovorum factor in megaloblastic anemiaVitamine und VitaminkrankheitenTHE ORAL USE OF COMBINED VITAMIN B12 AND FOLIC ACID IN TROPICAL SPRUE*RIVAS FEDERICO DIÉZ, M.D., MORALES FEDERICO HERNÁNDEZ, M.D., F.A.C.P., LEO M. MEYER, M.D.Interrelationship of Folic Acid and Vitamin B12 in Macrocytic Anemia Associated with Linitis Plastica1Fortschritte auf dem Gebiet der Pellagra-ForschungFolic acid treatment of a case of prolonged acute gingival hemorrhageVitamin Supplementation in Health and DiseaseA Comparison of Pteroylglutamic Acid and Liver Extract Maintenance Therapy in SprueThe Diagnosis and Pathogenesis of Tropical Sprue.Sprue: A Consideration of Etiology, Differential Diagnosis and ManagementFifth Announcement of the U.S.P. Anti-Anemia Preparations Advisory BoardThe Treatment of Anemia“Folic Acid”: Pteroylglutamic Acid and Related Substances 1 May 1947Volume 26, Issue 5Page: 643-677KeywordsAnemiaBone marrowDrug discoveryDrugsFatsFolic acidLactobacillusPatientsPernicious anemiaReticulocytes ePublished: 1 December 2008 Issue Published: 1 May 1947 Copyright & PermissionsCopyright, 1947, by The American College of PhysiciansPDF downloadLoading ...