Exacerbation of Pseudogout by Granulocyte Colony-Stimulating Factor
Authors: Victor Sandor
Journal: Annals of Internal Medicine (1996)

Letters1 November 1996Exacerbation of Pseudogout by Granulocyte Colony-Stimulating FactorVictor Sandor, MD, Raffit Hassan, MD, and Elise Kohn, MDVictor Sandor, MDNational Cancer Institute Bethesda, MD 20892.Search for more papers by this author, Raffit Hassan, MDNational Cancer Institute Bethesda, MD 20892.Search for more papers by this author, and Elise Kohn, MDNational Cancer Institute Bethesda, MD 20892.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-125-9-199611010-00029 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:We report a case of reactivation of pseudogout by granulocyte colony-stimulating factor (G-CSF) in a patient receiving chemotherapy for ovarian cancer. To our knowledge, this is the first report of this side effect of G-CSF.A 70-year-old woman was treated with 9-aminocamptothecin (9-AC) on a National Cancer Institute phase II trial for refractory epithelial ovarian carcinoma. 9-Aminocamptothecin was administered in 14-day cycles at 47 µg/m2 body surface area per hour over 72 hours. Treatment with G-CSF (5 µg/kg) was started on day 5 of each cycle and was continued for 8 days. At evaluation for her third ...References1. Lord BI, Bronchud MH, Owens S, Chang J, Howell A, Souza L, et al. The kinetics of human granulopoiesis following treatment with granulocyte colony-stimulating factor in vivo. Proc Natl Acad Sci U S A. 1989; 86:9499-503. Google Scholar2. Lindeman A, Herrmann F, Oster W, Haffner G, Meyenburg W, Souza LM, et al. Hematologic effects of recombinant human granulocyte colony-stimulating factor in patients with malignancy. Blood. 1989; 74:2644-51. Google Scholar3. Terkeltaub RA, Ginsberg MH. The inflammatory reaction to crystals. Rheum Dis Clin North Am. 1988; 2:353-64. Google Scholar Author, Article, and Disclosure InformationAffiliations: National Cancer Institute Bethesda, MD 20892. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByRecurrent arthritis as an unexpected side effect associated with azacitidine in a patient with myelodysplastic syndromePseudogout Attack after Pegfilgrastim Administration in Anaplastic Large Cell LymphomaCalcium Crystal DiseaseCalcium Pyrophosphate Dihydrate Crystal DepositionDiseases Associated with Articular Deposition of Calcium Pyrophosphate Dihydrate and Basic Calcium Phosphate CrystalsGranulocyte Colony–Stimulating Factor Administration: Adverse EventsConsecutive pseudogout attacks after repetitive granulocyte colony-stimulating factor administration for neutropeniaAcute pseudogout following contrast angiographyNeutropénies constitutionnelles et acquisesNeutropénies constitutionnelles et acquisesThe current prospects for neutrophil transfusions for the treatment of granulocytopenic infected patientsClinical trials review: Crystal deposition diseasesFamilial and clinical aspects of calcium pyrophosphate deposition diseasAcute pseudogout following intra-articular injection of high molecular weight hyaluronic acidSELECTED DRUG COMPLICATIONS AND TREATMENT CONFLICTS IN THE PRESENCE OF COEXISTENT DISEASESDrugs acting on the immune system 1 November 1996Volume 125, Issue 9Page: 781KeywordsCalciumGranulocyte colony stimulating factorKneesNeutrophilsPatient advocacyPhagocytosisPhase 2 trialsThyroidUltrasound imagingUric acid Issue Published: 1 November 1996 CopyrightCopyright © 1996 by American College of Physicians. All Rights Reserved.PDF DownloadLoading ...