tbuckley/cabot-search huggingface dataset:
Limitations of the 1990 American College of Rheumatology Classification Criteria in the Diagnosis of Vasculitis
Authors: Jaya K. Rao
Journal: Annals of Internal Medicine (1998)

Background: The American College of Rheumatology (ACR) established criteria to discriminate among patients with seven types of vasculitis. Although designated as "classification criteria" for research, these criteria are often used for diagnosis. Objective: To examine the operating characteristics of the 1990 ACR classification criteria in the diagnosis of Wegener granulomatosis, giant-cell arteritis, polyarteritis nodosa, and hypersensitivity vasculitis. Design: Prospective cohort study. Setting: University medical center and Veterans Affairs medical center. Patients: 198 consecutive patients referred to rheumatologists for evaluation of possible vasculitis. Measurements: Blinded chart audits were done to classify patients according to the 1990 ACR classification criteria for Wegener granulomatosis, polyarteritis nodosa, giant-cell arteritis, and hypersensitivity vasculitis on the basis of the patients' initial presentation. Chart audits done 2 to 8 months after baseline provided the patients' final diagnoses, which were considered the gold standard, as in the development of the ACR criteria. Test operating characteristics of the ACR classification criteria were calculated according to 2 × 2 tables for the entire cohort and for only the patients with a final diagnosis of vasculitis. Results: Vasculitis was diagnosed in 51 (26%) patients. Thirty-eight (75%) of 51 patients with vasculitis and 31 (21%) of 147 patients without vasculitis met ACR criteria for one or more types of vasculitis. The positive predictive values for the four vasculitides according to ACR criteria were 17% to 29% for the entire cohort and 29% to 75% for only the patients with a final diagnosis of vasculitis. Conclusion: The 1990 ACR classification criteria function poorly in the diagnosis of specific vasculitides.
Thermography in Mass Screening for Occult Breast Cancer
Authors: Claude R. Hitchcock
Journal: JAMA (1968)

Thermography as a potential method for screening large segments of the population for breast cancer was studied in Minneapolis in a group of 2,523 volunteer women. There was an unacceptably large group wherein the thermogram was read as abnormal but no lesion could subsequently be proved. The reliability of the method was inadequate, since out of four patients diagnosed as having breast cancer, only one was found by thermogram. The examining physician diagnosed two of the lesions as suspicious and these were missed by the thermographic technique. The remaining lesion was missed by the examining physician and an initial reading of the thermogram as suspicious was changed to normal. The presence of technical difficulties and inability to examine women with large, pendulous breasts seemed to further invalidate this method as a logical screening procedure.
Individuals with complete filaggrin deficiency may have an increased risk of squamous cell carcinoma
Authors: J. Kaae, P.B. Szecsi, M. Meldgaard, M.L.M. Espersen, S. Stender, J.D. Johansen, J. Bandier, J.P. Thyssen, T. Menné, S.L. Nielsen, E. Høgdall, E. Balslev, L. Skov
Journal: British Journal of Dermatology (2014)

Journal Article Individuals with complete filaggrin deficiency may have an increased risk of squamous cell carcinoma Get access J. Kaae, J. Kaae Department of Dermato‐Allergology Gentofte Hospital University of Copenhagen 2900‐Hellerup Denmark Search for other works by this author on: Oxford Academic Google Scholar P.B. Szecsi, P.B. Szecsi Department of Clinical Biochemistry Gentofte Hospital University of Copenhagen Hellerup Denmark Search for other works by this author on: Oxford Academic Google Scholar M. Meldgaard, M. Meldgaard Department of Clinical Biochemistry Gentofte Hospital University of Copenhagen Hellerup Denmark Search for other works by this author on: Oxford Academic Google Scholar M.L.M. Espersen, M.L.M. Espersen Department of Pathology Herlev Hospital University of Copenhagen Herlev Denmark Search for other works by this author on: Oxford Academic Google Scholar S. Stender, S. Stender Department of Clinical Biochemistry Gentofte Hospital University of Copenhagen Hellerup Denmark Search for other works by this author on: Oxford Academic Google Scholar J.D. Johansen, J.D. Johansen National Allergy Research Centre Gentofte Hospital University of Copenhagen Hellerup Denmark Search for other works by this author on: Oxford Academic Google Scholar J. Bandier, J. Bandier National Allergy Research Centre Gentofte Hospital University of Copenhagen Hellerup Denmark Search for other works by this author on: Oxford Academic Google Scholar J.P. Thyssen, J.P. Thyssen Department of Dermato‐Allergology Gentofte Hospital University of Copenhagen 2900‐Hellerup Denmark Search for other works by this author on: Oxford Academic Google Scholar T. Menné, T. Menné Department of Dermato‐Allergology Gentofte Hospital University of Copenhagen 2900‐Hellerup Denmark Search for other works by this author on: Oxford Academic Google Scholar S.L. Nielsen, S.L. Nielsen Department of Pathology Herlev Hospital University of Copenhagen Herlev Denmark Search for other works by this author on: Oxford Academic Google Scholar ... Show more E. Høgdall, E. Høgdall Department of Pathology Herlev Hospital University of Copenhagen Herlev Denmark Search for other works by this author on: Oxford Academic Google Scholar E. Balslev, E. Balslev Department of Pathology Herlev Hospital University of Copenhagen Herlev Denmark Search for other works by this author on: Oxford Academic Google Scholar L. Skov L. Skov Department of Dermato‐Allergology Gentofte Hospital University of Copenhagen 2900‐Hellerup Denmark Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 170, Issue 6, 1 June 2014, Pages 1380–1381, https://doi.org/10.1111/bjd.12911 Published: 01 June 2014
Inorganic particle content of foods and drugs
Authors: William V. Eisenberg
Journal: Environmental Health Perspectives (1974)

Inorganic particulate matter in foods and drugs is discussed from the standpoint of determination by optical microscopy, source, and regulatory significance. Some particulate matter may be generated as extraneous material and traced to specific operational practices during processing and production with excessive levels associated with deficiencies in good manufacturing practices. Other particles, such as talc and asbestos, may be incorporated as additives during their use in production. Data on particles in parenteral drugs are discussed generally. Specific data on glass particles in foods and sand and soil particles in spices are presented.
478 NEW INSIGHTS INTO THE ANGIOTENSIN 1-7/MAS RECEPTOR INTERACTION FROM A MURINE MODEL OF HEPATIC FIBROSIS AND HEPATIC STELLATE CELL CULTURE
Authors: J.S. Lubel, C.B. Herath, Z. Jia, J. Tchongue, W. Sievert, L.M. Burrell, P.W. Angus
Journal: Journal of Hepatology (2008)
Submicroscopic Cytochemistry, vol 1: Proteins and Nucleic Acids; vol 2: Membranes, Mitochondria, and Connective Tissues
Authors: Hubert R. Catchpole
Journal: JAMA (1974)

These volumes represent the work of a classical morphologist assisted by four co-workers. Gersh brings to the fields of electron microscopy and submicroscopic cytology a formidable technical proficiency combined with biological insight of a high order. The result is a highly distinctive contribution to rational biology. At the same time, ultrastructural research is raised to a new order of sophistication. Adapted to the demanding requirements of electron microscopy is Gersh's method of ultrarapid freezing and drying that he pioneered in histochemistry a generation back and that is being independently validated in the field of biological cryoresearch. Added is his technique of fixation by cross-linking, using organometallic vapors and other reagents in vacuo. This method, introduced ten years ago, is now refined to include reactions for proteins, lipids, nucleic acids, and carbohydrates, with a specificity defended by a multiplicity of tests. Characteristic is the constant attempt to validate methodology and interpretations
Coronary Stenting Decreases Restenosis in Lesions With Early Loss in Luminal Diameter 24 Hours After Successful PTCA
Authors: Alfredo E. Rodriguez, Omar Santaera, Miguel Larribau, Mario Fernandez, Ricardo Sarmiento, Nestor Perez Baliño, John B. Newell, Gary S. Roubin, Igor F. Palacios
Journal: Circulation (1995)

Background Early loss of minimal luminal diameter (MLD) after successful percutaneous transluminal coronary angioplasty (PTCA) is associated with a higher incidence of late restenosis. Methods and Results Sixty-six patients (66 lesions) with &gt;0.3 mm MLD loss at 24-hour on-line quantitative coronary angiography were randomized into two groups: 1, Gianturco-Roubin stent (n=33) and 2, Control, who received medical therapy only (n=33). All lesions were suitable for stenting. Baseline demographic, clinical, and angiographic characteristics were similar in the two groups. Restenosis (≥50% stenosis) for the overall group occurred in 32 of 66 patients (48.4%) at 3.6±1-month follow-up angiography. Restenosis was significantly greater in group 2 than in group 1 (75.7% versus 21.2%, P &lt;.001). Vascular complications (21.2% versus 0%) and length of hospital stay (7.3±1 versus 2.4±0.5 days, P &lt;.01) were higher for the stent group. Although at follow-up there were no differences in mortality or incidence of acute myocardial infarction between the two groups, patients in the control group had a higher incidence of repeat revascularization procedures (73% versus 21%, P &lt;.001). Conclusions In patients with successful PTCA but reduced luminal diameter demonstrated by repeat angiography at 24 hours, the Gianturco-Roubin stent appears to reduce angiographic restenosis at follow-up.
Beyond the Melting Pot. The Negroes, Puerto Ricans, Jews, Italians, and Irish of New York City.
Authors: Marjorie C. Meehan
Journal: JAMA (1963)

Despite the expectation that ethnic differences would disappear as "true Americans" emerged from the melting pot, many racial and national groups have maintained their identity, and consequently face different problems. Glazer, a sociologist of Jewish family, and Moynihan, a political scientist of Irish background, have reviewed the history of five such ethnic groups in New York, and studied their present status. The authors have synthesized material from the literature with personal observations and have not hesitated to express their own opinions. This book, although sociological rather than medical, should interest most physicians, since it will help them understand the problems many of their patients face. The strong family loyalty of Italians may lead to lack of ambition for education and personal advancement, or may be a basis for mental conflict in the individuals who seek independence. The success of Jews in many areas, with their exclusion from high-level positions in
Quantitative variation of the common acute lymphoblastic leukemia antigen (gp100) on leukemic marrow blasts.
Authors: A T Look, S L Melvin, L K Brown, M E Dockter, P K Roberson, S B Murphy
Journal: Journal of Clinical Investigation (1984)

Marrow blasts from children with B cell precursor acute lymphoblastic leukemia (ALL) were studied for differences in quantitative expression of the common ALL antigen (CALLA). Of 42 untreated patients, 35 had detectable amounts of CALLA by flow cytometric (FCM) analysis of J-5 monoclonal antibody binding. Using an FCM technique that provides correlated measurements of a given cell surface antigen, cell size, and DNA content, we detected increased CALLA expression as lymphoblasts moved from G0/G1 phase through S phase of the cell cycle. The density of the antigen (per unit of blast surface area) remained relatively constant over the same interval, indicating that the change was not due to S phase-specific enhancement of CALLA expression. Eight cases had hyperdiploid cellular DNA content and in seven of these, only cells with clonal abnormalities of DNA content expressed the CALLA marker. Mean amounts of CALLA for each patient ranged widely within the study group, from very high to marginally detectable. This variation had no discernible relation to cell size, stem-line DNA content, percentage of cells in S phase, or the presence or absence of cytoplasmic immunoglobulin. Results of a univariate proportional hazards analysis showed that both quantitative level of CALLA for S phase cells (P = 0.048) and white blood cell count (P = 0.012) had made significant contributions to treatment outcome. Patients with relative amounts of CALLA less than the median value for the entire CALLA+ group had a higher rate of failure, which was virtually identical to that for the seven HLA-DR+ patients whose blasts lacked detectable CALLA. The observed interpatient variation in quantitative expression of CALLA is consistent with recognized steps in B cell precursor differentiation and may be useful in distinguishing patients with a less favorable prognosis.
The efficacy of DNA vaccination is enhanced in mice by targeting the encoded protein to dendritic cells
Authors: Godwin Nchinda, Janelle Kuroiwa, Margarita Oks, Christine Trumpfheller, Chae Gyu Park, Yaoxing Huang, Drew Hannaman, Sarah J. Schlesinger, Olga Mizenina, Michel C. Nussenzweig, Klaus Überla, Ralph M. Steinman
Journal: Journal of Clinical Investigation (2008)

DNA vaccines promote an immune response by providing antigen-encoding DNA to the recipient, but the efficacy of such vaccines needs improving. Many approaches have considerable potential but currently induce relatively weak immune responses despite multiple high doses of DNA vaccine. Here, we asked whether targeting vaccine antigens to DCs would increase the immunity and protection that result from DNA vaccines. To determine this, we generated a DNA vaccine encoding a fusion protein comprised of the vaccine antigen and a single-chain Fv antibody (scFv) specific for the DC-restricted antigen-uptake receptor DEC205. Following vaccination of mice, the vaccine antigen was expressed selectively by DCs, which were required for the increased efficacy of MHC class I and MHC class II antigen presentation relative to a control scFv DNA vaccine. In addition, a DNA vaccine encoding an HIV gag p41-scFv DEC205 fusion protein induced 10-fold higher antibody levels and increased numbers of IFN-gamma-producing CD4+ and CD8+ T cells. After a single i.m. injection of the DNA vaccine encoding an HIV gag p41-scFv DEC205 fusion protein, mice were protected from an airway challenge with a recombinant vaccinia virus expressing the HIV gag p41, even with 1% of the dose of nontargeted DNA vaccine. The efficacy of DNA vaccines therefore may be enhanced by inclusion of sequences such as single-chain antibodies to target the antigen to DCs.
Assessment for Three Different Forms of Short-Term Dynamic Psychotherapy
Authors: Karin Barth, Geir Nielsen, Odd E. Havik, Brit Haver, Ester Mølstad, Henrik Rogge, Marit Skåtun, Astrid Nøklebye Heiberg, Holger Ursin
Journal: Psychotherapy and Psychosomatics (1988)

Forty-four patients were assessed for three different short-term dynamic therapies, with an evaluation form based on Sifneos' criteria for Short-Term Anxiety-Provoking Psychotherapy (STAPP). Ten patients were ascribed to STAPP, 22 patients to Malan's Brief Psychotherapy (BP), and 12 patients to a more eclectic/integrative form of brief psychotherapy in this project called the FIAT model. 78% of the patients completed their treatment in agreement with the original ascription to therapy, with good results for all three therapies. The evaluation form seems to be a reliable and valid instrument offering a good and systematic basis for designing a tailor-made treatment format for different types of patients.
THE OCULAR SYMPTOMS OF BRIGHT'S DISEASE.Read before the Kings County Medical Association, Brooklyn, N. Y. November 8, 1889.
Authors: L. A. W. ALLEMAN
Journal: JAMA (1890)

There are some diseases which always present profitable subjects for consideration; they never grow old, never uninteresting. In the light of ever varying and broadening experience, some old and familiar fact possesses a new and vital interest. Some facts, indeed, we have heard so constantly that we have grown deaf to them by their very repetition, till some emergency makes us eagerly strive to summon them from the shadowy realm of half-forgetfulness. It is, therefore, with less reluctance that I ask your attention to a subject upon which I can hope to say nothing new, nothing original. "The Ocular Symptoms of Blight's Disease" is, it seems to me, a subject, the importance of which it is hard to overestimate. In the eye, as nowhere else in the body, a nerve, arteries and veins are exposed to our view, a lens even being kindly provided to assist us in our examination.
Different genomic imbalances in low- and high-grade HCV-related lymphomas
Authors: C Matteucci, M Bracci, G Barba, M Carbonari, M Casato, M Visentini, A Pulsoni, E Varasano, G Roti, R La Starza, B Crescenzi, M F Martelli, M Fiorilli, C Mecucci
Journal: Leukemia (2007)
Radiofrequency Identification Technology in Health Care
Authors: Binita S. Ashar, Ann Ferriter
Journal: JAMA (2007)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Polymorphisms in the Endothelin-1 and Endothelin A Receptor Genes and Survival in Patients with Locoregionally Advanced Nasopharyngeal Carcinoma
Authors: Yue-Feng Wen, Bin Qi, Huai Liu, Hao-Yuan Mo, Qiu-Yan Chen, Juan Li, Pei-Yu Huang, Yan-Fang Ye, Ying Zhang, Man-Quan Deng, Xiang Guo, Ming-Huang Hong, Ka-Jia Cao, Hai-Qiang Mai
Journal: Clinical Cancer Research (2011)

We aimed to investigate the prognostic role of endothelin-1 (EDN1) and endothelin A receptor (EDNRA) gene polymorphisms in patients with locoregionally advanced nasopharyngeal carcinoma (NPC).Two hundred three consecutive patients with locoregionally advanced NPC were enrolled. Seven potentially functional polymorphisms in the EDN1 and EDNRA genes were determined by ligase detection reaction-PCR method from prospectively collected blood samples. The influence of the genetic polymorphisms on patient overall survival (OS) was analyzed using Cox proportional hazards model, Kaplan-Meier method, and the log-rank test.The 5-year OS in patients with EDNRA/H323H TT, TC, and CC genotypes were 81.3%, 62.1%, and 75.0%, respectively (P = 0.004). Patients carrying the heterozygous (TC) or homozygous variant (CC) genotype in EDNRA/H323H were combined for analysis, which revealed that the 5-year OS in patients with TC/CC genotypes was significantly lower than those with the wild-type TT genotype (63.2% vs. 81.3%; P = 0.002). Multivariate analysis showed that EDNRA/H323H polymorphism (HR: 1.95; 95% CI: 1.18-3.23; P = 0.009) and N classification (HR: 1.35; 95% CI: 1.03-1.79; P = 0.03) were independent significant prognostic factors for OS in patients with locoregionally advanced NPC. In contrast, the EDN1 polymorphisms revealed no prognostic value.The EDNRA/H323H polymorphism was a novel and independent prognostic marker for patients with locoregionally advanced NPC. The analysis of EDNRA/H323H polymorphism may help identify patient subgroups at high risk for poor disease outcome.
Neuronal Pentraxin 2 Supports Clear Cell Renal Cell Carcinoma by Activating the AMPA-Selective Glutamate Receptor-4
Authors: Christina A. von Roemeling, Derek C. Radisky, Laura A. Marlow, Simon J. Cooper, Stefan K. Grebe, Panagiotis Z. Anastasiadis, Han W. Tun, John A. Copland
Journal: Cancer Research (2014)

Clear cell renal cell carcinoma (ccRCC) is the most common subtype of kidney cancer and has the highest propensity to manifest as metastatic disease. Recent characterizations of the genetic signature of ccRCC have revealed several factors correlated with tumor cell migration and invasion; however, the specific events driving malignancy are not well defined. Furthermore, there remains a lack of targeted therapies that result in long-term, sustainable response in patients with metastatic disease. We show here that neuronal pentraxin 2 (NPTX2) is overexpressed specifically in ccRCC primary tumors and metastases, and that it contributes to tumor cell viability and promotes cell migration through its interaction with the α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor subunit GluR4. We propose NPTX2 as a novel molecular target for therapy for patients with ccRCC diagnosed with or at risk of developing metastatic disease.
What happens when pay for performance stops?
Authors: B. Guthrie, D. R. Morales
Journal: BMJ (2014)

No evidence of serious harm so far, but future changes need evaluation

Financial incentives for quality in pay for performance programmes are an attractive improvement method for healthcare payers worldwide, and the UK Quality and Outcomes Framework (QOF) is still one of the largest such programmes. Evidence shows that the QOF improved incentivised quality of care and reduced variation between practices. However, the effect for most indicators was relatively small, was not always persistent, and was partly balanced by negative effects on non-incentivised care.1 2 3 The QOF and pay for performance more generally are therefore clearly not magic bullets for improvement,4 and many uncertainties remain. The paper by Kontopantelis and colleagues (doi: 10.1136/bmj.g330) examines one of these important uncertainties—what happens when financial incentives for quality are withdrawn.5

Removal of incentivised indicators has several rationales, including lack of initial effectiveness, lack of continued improvement, and to allow the targeting of other priority areas. Over the nine years of the QOF’s existence, large changes to structural and organisational process indicators have been made, but relatively few indicators relating to clinical care have been retired. Instead, funding to introduce new clinical indicators has come largely from reallocating resources from organisational indicators. More …
A strange(r) analysis of morality: A consideration of relational context and the broader literature is needed
Authors: Margaret S. Clark, Erica Boothby
Journal: Behavioral and Brain Sciences (2013)

Abstract Baumard et al.'s definition of morality is narrow and their review of empirical work on human cooperation is limited, focusing only on economic games, almost always involving strangers. We suggest that theorizing about mutualisms will benefit from considering extant empirical behavioral research far more broadly and especially from taking relational context into account.