CARDIOVASCULAR EFFECTS OF LARGE DOSES OF METRAZOL AS EMPLOYED IN THE TREATMENT OF SCHIZOPHRENIA
Authors: E. Messinger, N. Moros
Journal: Annals of Internal Medicine (1940)

Article1 January 1940CARDIOVASCULAR EFFECTS OF LARGE DOSES OF METRAZOL AS EMPLOYED IN THE TREATMENT OF SCHIZOPHRENIAE. MESSINGER, A.B., M.D., N. MOROS, B.S., M.D.E. MESSINGER, A.B., M.D.Search for more papers by this author, N. MOROS, B.S., M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-13-7-1184 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptSince von Meduna1 first reported his success in the treatment of schizophrenia by the induction of convulsions with metrazol, his method has enjoyed considerable popularity, and has been employed in many hundreds of cases.His method consists essentially in the repeated (three times weekly) induction of severe epileptiform convulsions of a specific type by the rapid intravenous injection of large doses of metrazol (pentamethylenetetrazol, formerly known as cardiazol), in a 10 per cent aqueous solution. The initial dose usually employed is 3 to 5 c.c. and it is usually increased progressively so that convulsions are regularly obtained—until a course of...Bibliography1. VON MEDUNA L: Convulsive therapy of schizophrenia, Psychiat.-neurol. Wchnschr., 1935, xxxvii, 317. Google Scholar2. VON ANGYALGYÁRFÁS LK: Über die Cardiazol-Krampfbehandlung der Schizophrenie, Arch. f. Psychiat., 1936, cvi, 1. Google Scholar3. FRIEDMAN E: Irritative therapy of schizophrenia, New York State Jr. Med., 1937, xxxvii, 1813-1821. Google Scholar4. FINKELMANSTEINBERGLIEBERT IDLE: The treatment of schizophrenia with metrazol by the production of convulsions, Jr. Am. Med. Assoc., 1938, cx, 706-709. CrossrefGoogle Scholar5. KRUGER L: Treatment of schizophrenia by Meduna's method, Psychiat.-neurol. Wchnschr., 1936, xxxviii, 135. Google Scholar6. VON MEDUNA L: General discussion of cardiazol therapy, Am. Jr. Psychiat., 1938, supp. xciv, 48. Google Scholar7. MÜLLER EA: Die Herz und Kreislaufswirkung des Cardiazols, Klin. Wchnschr., 1936, xv, 233-235. CrossrefGoogle Scholar8. STOLANDGINSBERG OOAM: Effect of coramine and metrazol on coronary circulation, Jr. Pharmacol. and Exper. Therap., 1937, lx, 396-406. Google Scholar9. SCHLAEPFER K: Antagonistic effect of metrazol to shock and anesthetic depression, Anesth. and Analg., 1936, xv, 202. Google Scholar10. MESSINGER E: Cardio-vascular changes associated with insulin shock treatment, ANN. INT. MED., 1938, xii, 853. Google Scholar11. MILLESSMITH GPW: Effects of epinephrine on the heart, Am. Heart Jr., 1937, xiv, 198. CrossrefGoogle Scholar12. PARADEFOERSTER GWHR: Die Wirkung intravenöser Injektion von Adrenalin und Pilocarpin auf die Herzaktion, Klin. Wchnschr., 1934, xiii, 1709-1711. CrossrefGoogle Scholar13. HEINRICHSUSSNER AH: Action of crystalline insulin on blood pressure, respiration, and electrocardiogram, as well as modification of these effects by metrazol, Ztschr. f. klin. Med., 1937, cxxxiii, 208. Google Scholar14. HADORN N: Studies on heart in hypoglycemic shock, with particular reference to electrocardiographic observations in insulin therapy of schizophrenia: electrocardiogram during metrazol shock therapy of schizophrenia, Arch. f. Kreislaufforschung, Dresden, 1937, ii, 1-156. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Northport, Long Island, New York*Received for publication July 23, 1938.Article No. 45—From the Neuro-Psychiatric Research Unit for the Study of the Influence of Heterophile Antigen in Nervous and Mental Disease. Veterans Administration Facility, Northport, L.I., N.Y.Published with the permission of the Medical Director who assumes no responsibility for the opinions expressed or conclusions drawn. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byCardiac arrest during intravenous metrazol administration. Report of a case during EEG activation procedureEffects of Pentylenetrazol on Senile PatientsConvulsion TherapySome observations on cardiovascular changes in shock therapyElectrocardiographic changes following metrazol-induced convulsions 1 January 1940Volume 13, Issue 7Page: 1184-1204KeywordsAntigensConvulsionsIntravenous injectionsSchizophrenia ePublished: 1 December 2008 Issue Published: 1 January 1940 PDF downloadLoading ...