tbuckley/cabot-search huggingface dataset:
A gene expression profile associated with clinical outcome in stage III melanoma.
Authors: J. Falkenius, J. Lindberg, H. Johansson, M. Frostvik-Stolt, J. Lundeberg, J. Hansson, S. Egyhazi
Journal: Journal of Clinical Oncology (2011)

8551 Background: Patients with regionally disseminated malignant cutaneous melanoma, stage III, have a variable prognosis with reported 5-year survival of 24-67%, depending on subcategory. There is a subgroup of patients with a better long-term survival, even when known adverse pathological risk factors, such as macro-metastasis, number of lymph node metastases and ulceration are taken into consideration. Identification of a molecular profile may predict subgroups of patients with prognostic benefits of adjuvant treatments in stage III disease. Methods: A RNA oligonucleotide microarray study was performed on lymph node metastases from 42 patients with stage III melanoma: 19 patients with short survival (≤ 14 months) and 23 with long survival (≥ 60 months). Candidate genes were validated by qRT-PCR and IHC. Results: Categorization according to the biological functions revealed gene ontology (GO) clusters that are highly significantly differentially expressed between the prognosis groups. Two of the top categories were glycolysis (GO: 0006096) (p<0.001) and pigment biosynthetic process (GO: 0046148) (p<0.001). No single gene was significantly differentially expressed between the groups. Four genes from the two top GO categories, GAPDHS, GAPDH, PKM2 and TYRP1, were selected for validation. Best result is found for GAPDHS in both qRT-PCR (p=0.11) and IHC (p=0.012). The median relative quantity values for all mRNAs are lower for those with good outcome compared to those with poor outcome. When combining the results from IHC a significant finding was observed. High expression of at least two of these four gene products was found to be an independent adverse prognostic factor for overall survival in a multivariate analysis (p=0.037). Conclusions: We have identified a prognostic panel of four gene products associated with clinical outcome in stage III melanoma.
Augmented reality guidance for needle biopsies: An initial randomized, controlled trial in phantoms††A preliminary version of this paper was presented at the Medical Image Computing and Computer-Assisted Intervention (MICCAI) 2001 conference in Utrecht. The Netherlands (Rosenthal et al., 2001)
Authors: Michael Rosenthal, Andrei State, Joohi Lee, Gentaro Hirota, Jeremy Ackerman, Kurtis Keller, Etta D Pisano, Michael Jiroutek, Keith Muller, Henry Fuchs
Journal: Medical Image Analysis (2002)
Abstract 19283: Incremental Prognostic Value of Discordant Amino Terminal Pro B-type Natriuretic Peptide Compared to B-type Natriuretic Peptide Levels in Stable Patients with Heart Failure
Authors: Justin L Grodin, Muhammad Hammadah, Stanley L Hazen, W. H. W Tang
Journal: Circulation (2014)

Background:  Pro B-type natriuretic peptide is cleaved into amino terminal pro B-type natriuretic peptide (NT-proBNP) and B-type natriuretic peptide (BNP). NT-proBNP has a longer half life than BNP (25-70 vs. 13-20 min, respectively) and, unlike BNP, is biologically inactive. The prognostic significance of discordant NT-proBNP compared to BNP levels is unknown in patients with heart failure.   Hypothesis:  We hypothesize that higher a higher difference in NT-proBNP to BNP levels predicts all-cause mortality after adjustment for traditional cardiac risk factors and NT-proBNP or BNP levels.   Methods:  We measured the difference between baseline NT-proBNP and BNP levels in 508 sequential stable patients with a history of heart failure who were undergoing elective coronary angiography without acute coronary syndrome, with 5-year follow-up of all-cause mortality. NT-proBNP (Roche), BNP (Abbott), and troponin (hs-cTnT, Roche 5th gen) were measured. Glomerular filtration rate (GFR) was estimated by MDRD equation.   Results:  In our study cohort (mean age 67±11 years, 63% male, 36% diabetic, median NT-proBNP 1025 pg/mL and median BNP 306 pg/mL) the median NT-proBNP-BNP difference was 677 pg/mL (interquartile range 227-1915 pg/mL) and 166 subjects died over 5-years. High NT-proBNP-BNP was associated with a 4.5-fold increase in 5-year mortality risk (Quartile 4 versus 1: Hazard ratio [95% confidence interval] 3.45 [2.78-7.44], p   Conclusions:  A higher discrepancy in NT-proBNP to BNP provided independent and incremental prognostic value for mortality prediction beyond their individual levels in chronic heart failure. These findings support the hypothesis that chronic cleavage and impaired clearance of natriuretic peptides is maladaptive in heart failure.
Abstract 16305: Incidence and Timing of High-Risk Arrhythmias With Long-Term Continuous Ambulatory Electrocardiographic Monitoring
Authors: Matthew D Solomon, Jingrong Yang, Judy Lenane, Sue Hee Sung, Alan S Go
Journal: Circulation (2014)

Background: Ambulatory electrocardiographic (ECG) monitoring is the standard of care to screen patients for arrhythmias. However, there is marked variation in the technological features and patient adherence among different ECG monitoring systems. We evaluated a novel adhesive, wireless, single-lead, full-disclosure, up to 14-day ECG monitoring system to measure the burden and timing of high-risk arrhythmias. Methods: We examined data from 122,815 long term continuous ambulatory ECG Monitors. (ZIO® Patch Service, iRhythm Technologies, San Francisco, CA) from 2011-2013 and categorized high-risk arrhythmias into two types: (1) ventricular arrhythmias including non-sustained and sustained ventricular tachycardia and (2) high risk bradyarrhythmias including sinus pauses &gt;3 seconds, atrial fibrillation pauses &gt;5 seconds, and high grade heart block including Mobitz Type II or third-degree heart block. We calculated the proportion of patients with each arrhythmia and the elapsed wear time until each arrhythmia. Results: Of 122,815 Ziopatch recordings, median wear time was 9.9 (IQR 6.8-13.8) days and median analyzable time was 9.1 (IQR 6.4-13.1) days. There were 22,443 (18.3%) with at least one episode of non-sustained ventricular tachycardia (NSVT), 238 (0.2%) with sustained VT, 1,766 (1.4%) with a sinus pause &gt;3 seconds (SP), 520 (0.4%) with a pause during atrial fibrillation &gt;5 seconds (AFP), and 1,486 (1.2%) with high-grade heart block. Median time to first arrhythmia was 74 hours (IQR 26 -149 hours) for NSVT, 22 hours (IQR 5-73 hours) for sustained VT, 22 hours (IQR 7-64 hours) for SP, 31 hours (IQR 11-82 hours) for AFP, and 40 hours (SD 10-118 hours) for high-grade heart block. The yield over time is shown in the Figure 1. Conclusions: A significant percentage of high-risk arrhythmias can be identified by long term continuous monitoring for longer than 24 to 48 hours. The clinical impact from better identification of high-risk arrhythmias warrants further study.
Cutaneous angiomatosis following implanted osteosynthesis nail: a manifestation of nickel allergy?
Authors: E. Snellman, R.O. Niskanen, L. Jeskanen, H. Heikkilä
Journal: British Journal of Dermatology (2000)

Journal Article Cutaneous angiomatosis following implanted osteosynthesis nail: a manifestation of nickel allergy? Get access E. Snellman, E. Snellman Departments of Dermatology and Search for other works by this author on: Oxford Academic Google Scholar R.O. Niskanen, R.O. Niskanen Orthopaedics, Päijät‐Häme Central Hospital, Keskussairaalankatu 7, FIN‐15850 Lahti, Finland Search for other works by this author on: Oxford Academic Google Scholar L. Jeskanen, L. Jeskanen Departments of Histopathology and Search for other works by this author on: Oxford Academic Google Scholar H. Heikkilä H. Heikkilä Dermatology, Helsinki University Hospital, Helsinki, Finland E‐mail: erna.snellman@phks.fi Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 142, Issue 5, 1 May 2000, Pages 1056–1057, https://doi.org/10.1046/j.1365-2133.2000.03502.x Published: 01 May 2000
Association of Aspirin Use and Hormone Receptor Status With Breast Cancer Risk
Authors: Steven Woloshin, Lisa M. Schwartz
Journal: JAMA (2004)

To the Editor: The recent article by Dr Terry and colleagues provides important data on the chemopreventive effects of aspirin and breast cancer risk. It is likely that the preventive effect of nonsteroidal anti-inflammatory drugs (NSAIDs) is actually stronger than reported in this article. The analysis derived from the Long Island Breast Cancer Study Project was based only on reported use of aspirin, ibuprofen, or acetaminophen, so that any women who used other NSAIDs (including naproxen, etodolac, ketoprofen, and sulindac, which are available by prescription) would have been included in the nonuser category. Given that these medications are often used for arthritis or chronic pain, it is likely that a substantial number of the nonusers were actually regular users of prescription NSAIDs. This misclassification of users and nonusers would attenuate any true inverse association between NSAIDs and breast cancer. In a recent population-based case-control study, we found stronger inverse associations between NSAID use and breast cancer than those reported by Terry et al (regular use 3 years; odds ratio [OR], 0.33; 95% confidence interval [CI], 0.210.53). Moreover, the inverse association was stronger for prescription NSAIDs than for nonprescription NSAIDs. These findings stress the importance of having data on all types of NSAID use, not just aspirin, ibuprofen, and acetaminophen. Breast cancer chemoprevention with NSAIDs is an exciting prospect. Future studies should strive to collect complete data on NSAID use to obtain more accurate estimates of the protective effects. Furthermore, these studies should determine which NSAIDs are most efficacious in reducing breast cancer risk.
The Composition of Light
Authors: Peter Sordillo
Journal: JAMA (2004)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Mortality associated with oral contraceptive use
Authors: A. Szarewski, H. C Kitchener, J. Horowitz, C. Kahlenborn, E. C G Grant, C M. Steel, E. H Price, H. M Anthony, D. Downing, M. J Radcliffe, S. Myhill
Journal: BMJ (1999)

# Confounding might have accounted for results {#article-title-2} EDITOR—Beral et al have reported an increased relative risk of death from cervical cancer among women using oral contraception.1 Their study controlled for smoking but not for the other principal risk factors for cervical cancer, which include infection with human papillomavirus of a high risk type, sexual behaviour, and inadequate cervical screening. There is therefore a considerable risk of confounding, which could account for the results. The authors do not give patterns of use of contraception by never users and non-users of oral contraceptives; it would be interesting to know what proportion of this comparison group was using barrier methods Such women are at reduced risk of cervical cancer,2 and therefore a comparison that includes a large proportion of women using barrier methods will seem, artificially, to increase any risk in pill users. It should also be noted that durations of use of less than 10 years are not associated with a significant increase in risk in this study This apparent duration of use effect may well be related to the risk of acquiring an infection with an oncogenic human papillomavirus. 1. 1.↵1. Beral V, 2. Hermon C, 3. Kay C, 4. Hannaford P, 5. Darley S, 6. Gillian R . Mortality associated with oral contraceptive use: 25 year follow up of cohort of 46 000 women from Royal College of General Practitioners' oral contraceptive study. BMJ 1999; 318: 96–100. (9 January.) [OpenUrl][1][Abstract/FREE Full Text][2] 2. 2.↵1. Schottenfeld D, 2. Fraumeni JF <!-- --> 1. Schiffman MH, 2. Brinton LA, 3. Devesa SS, 4. Fraumeni JF . Cervical cancer. In: Schottenfeld D, Fraumeni JF, eds. Cancer epidemiology and prevention. Oxford: Oxford University Press, 1996. # Relative risk of liver cancer remains high {#article-title-5} EDITOR—Beral et al state that, for ever users of oral contraceptives compared with never users, both the overall relative risk of death and the relative risk of death from all cancers are 1.0.1 They discuss the fact that the relative risk of cervical cancer is 1.7 but ignore … [1]: {openurl}?query=rft.jtitle%253DBMJ%26rft.stitle%253DBMJ%26rft.issn%253D0007-1447%26rft.aulast%253DBeral%26rft.auinit1%253DV.%26rft.volume%253D318%26rft.issue%253D7176%26rft.spage%253D96%26rft.epage%253D100%26rft.atitle%253DMortality%2Bassociated%2Bwith%2Boral%2Bcontraceptive%2Buse%253A%2B25%25A0year%2Bfollow%2Bup%2Bof%2Bcohort%2Bof%2B46%25A0000%2Bwomen%2Bfrom%2BRoyal%2BCollege%2Bof%2BGeneral%2BPractitioners%2527%2Boral%2Bcontraception%2Bstudy%26rft_id%253Dinfo%253Apmid%252F9880284%26rft.genre%253Darticle%26rft_val_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Ajournal%26ctx_ver%253DZ39.88-2004%26url_ver%253DZ39.88-2004%26url_ctx_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Actx [2]: /lookup/ijlink?linkType=ABST&journalCode=bmj&resid=318/7176/96&atom=%2Fbmj%2F319%2F7206%2F386.atom
Percutaneous coronary intervention versus coronary bypass graft surgery for patients with medically refractory myocardial ischemia and risk factors for adverse outcomes with bypass
Authors: Douglass A Morrison, Gulshan Sethi, Jerome Sacks, William Henderson, Frederick Grover, Steven Sedlis, Rick Esposito, Kodagundi B Ramanathan, Darryl Weiman, J.David Talley, Jorge Saucedo, Tamim Antakli, Venki Paramesh, Stuart Pett, Sarah Vernon, Vladimir Birjiniuk, Frederick Welt, Mitchell Krucoff, Walter Wolfe, John C Lucke, Sundeep Mediratta, David Booth, Charles Barbiere, Dan Lewis
Journal: Journal of the American College of Cardiology (2002)
Abstract P242: Abdominal Adipose Tissue Distribution and Metabolic Syndrome Burden in Adolescents - Penn State Child Cohort (PSCC) Study
Authors: Duanping Liao, Fan He, Sol Rodriguez-Colon, Julio Fernandez-Mendoza, Alexandros Vgontzas, Edward O Bixler
Journal: Circulation (2014)

Objectives: To investigate the association between abdominal adipose tissue distribution and metabolic syndrome burden in a population-based sample of adolescents. Methods: We used available data from 400 adolescents who completed the follow up examinations in the PSCC study. We used whole body low-dose dual energy absorptiometry (DXA) to assess and calculate the following abdominal and body fat distribution measures: Android/Gynoid Fat ratio, Android/whole body fat ratio, Gynoid/whole body fat ratio, visceral fat area, and subcutaneous fat area in the abdominal region. . Metabolic syndrome burden was assessed by using continuous metabolic syndrome score (cMetS) - the sum of the age and sex adjusted standardized residual (Z-score) of five established metabolic syndrome components: waist circumference, mean arterial pressure, homeostatic model assessment of insulin resistance (HOMA-IR), triglycerides, and HDL cholesterol. Linear regression models were used to data analysis. Results: The mean age was 16.9 yrs (SD=2.19), with 54% male and 77% white. The average cMets score was 0.04 SD (3.01). The regression coefficients on cMets score per one SD increase in abdominal adipose tissue measures are shown in Table 1. In summary, higher abdominal adipose tissue, especially in the android (visceral) area, of the abdomen is associated with higher cMetS score. Conclusion: Obesity, especially visceral obesity, is associated with higher metabolic syndrome burden in adolescent population, which may result in increased metabolic syndrome risk in adulthood.
Dietary manipulation for idiopathic nephrotic syndrome
Authors: J. LAURENT, G. LAGRUE
Journal: Allergy (1989)

To evaluate the role of food antigens in idiopathic nephrotic syndromes, we used dietary manipulations in 26 cases in whom steroid therapy had failed. In the six reported, restricted diets according to clinical and biological data were followed by complete remissions, suggesting that food can be responsible for idiopathic nephrotic syndrome in selected cases, and leading to a new therapeutic approach. The mechanism by which such antigens can be implicated in the pathogenesis of this glomerular disease is discussed.
ATYPICAL PNEUMONIA TREATED WITH STREPTOMYCIN: A PRELIMINARY REPORT ON THE EFFECTIVENESS OF STREPTOMYCIN IN ATYPICAL PNEUMONIA
Authors: F P KING
Journal: Annals of Internal Medicine (1951)

Article1 January 1951ATYPICAL PNEUMONIA TREATED WITH STREPTOMYCIN: A PRELIMINARY REPORT ON THE EFFECTIVENESS OF STREPTOMYCIN IN ATYPICAL PNEUMONIAFRANCIS P. KING, M.D.FRANCIS P. KING, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-34-1-141 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptAtypical pneumonia, until recently, has been considered a disease for which there was no specific treatment. With the announcement of two new drugs that apparently are specific cures for this disorder, aureomycin1, 2 and chloromycetin,3 another infectious disease was added to the already long list of those amenable to specific therapy.In reporting the use of aureomycin in atypical pneumonia, Finland, Collins and Wells4presented two cases of atypical pneumonia that appeared to respond dramatically to streptomycin. They also pointed out that they were able to find reported only two other cases of atypical pneumonia treated with streptomycin, and in...Bibliography1. KneelandRoseGibson YHMCD: Aureomycin in the treatment of primary atypical pneumonia, Am. J. Med. 6: 41, 1949. CrossrefMedlineGoogle Scholar2. ShoenbachBryer EBMS: Treatment of primary atypical non-bacterial pneumonia with aureomycin, J. A. M. A. 139: 275, 1949. CrossrefMedlineGoogle Scholar3. Wood EJ: Atypical pneumonia treated with chloromycetin, Lancet 2: 55, 1949. CrossrefMedlineGoogle Scholar4. FinlandCollinsWells MHSEB: Aureomycin in the treatment of primary atypical pneumonia, New England J. Med. 240: 241, 1949. CrossrefMedlineGoogle Scholar5. PulaskiWhite EJTT: Streptomycin: report of its clinical effects in 44 cases treated for various infections of the respiratory tract, Arch. Int. Med. 82: 217, 1948. CrossrefGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Atlanta, Georgia*Received for publication January 16, 1950.From the Medical Service, Grady Memorial Hospital. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byAntimicrobial Treatment for Viral and Related Infections 1 January 1951Volume 34, Issue 1Page: 141-147KeywordsDrug therapyInfectious diseasesMedical servicesPneumoniaStreptomycin ePublished: 1 December 2008 Issue Published: 1 January 1951 PDF downloadLoading ...
Hunger Disease. Studies by the Jewish Physicians in the Warsaw Ghetto.
Authors: Myron. Winick, Martha. Osnos
Journal: Annals of Internal Medicine (1980)

Reports of scientific studies on hunger and starvation undertaken by 28 Jewish physicians of the Warsaw ghetto from 1940 are fragmented and incomplete. The untimely death of the principal investigators, loss of the manuscript and eventual mass deportation of the Warsaw Jews inhibited completion until the present. Clinical, metabolic, and pathological consequences of hunger were investigated using subjects carefully selected to represent pure hunger disease without complicating infections. Studies were based on 3 considerations: 1. importance of the information; 2. expertise of the investigators; 3. possibility of carrying out the studies under existing conditions. The editor cites the studies on stimulus-response, carbohydrate metabolism, acid base balance, circulatory and blood changes, oculatory disturbances and gross organ change studies as particularly noteworthy
OX40 Expressed on Fresh Leukemic Cells From Adult T-Cell Leukemia Patients Mediates Cell Adhesion to Vascular Endothelial Cells: Implication for the Possible Involvement of OX40 in Leukemic Cell Infiltration
Authors: Akihiro Imura, Toshiyuki Hori, Kazunori Imada, Shin Kawamata, Yuetsu Tanaka, Sadao Imamura, Takashi Uchiyama
Journal: Blood (1997)
Mutation increases cancer risk in carriers of BRCA2
Authors: Judy Siegel-Itzkovich
Journal: BMJ (2001)

A single minor mutation in one gene has been the first factor identified as greatly increasing the risk of developing breast cancer at a comparatively young age among women who carry the BRCA2 gene mutation (Proceedings of the National Academy of Sciences 2001;98:3232-6).

The discovery was made by Dr Ephrat Levy-Lahad, a medical genetics researcher at Shaare Zedek Medical Center in Jerusalem, and her colleagues. Dr Levy-Lahad and her team looked at why only some women who carry the BRCA1 and BRCA2 mutations get breast cancer. They studied 257 …
Short-term Outcomes of Infants Enrolled in Randomized Clinical Trials vs Those Eligible but Not Enrolled
Authors: Elizabeth E. Foglia, Tracy L. Nolen, Sara B. DeMauro, Abhik Das, Edward F. Bell, Barbara J. Stoll, Barbara Schmidt
Journal: JAMA (2015)

This retrospective analysis of infants at National Institute of Child Health and Human Development Neonatal Research Network sites did not find differences in mortality or neonatal morbidity between trial participants and nonparticipants.
Pulmonary vascular response to exercise in symptomatic heart failure with reduced ejection fraction and pulmonary hypertension
Authors: Frederik H. Verbrugge, Matthias Dupont, Philippe B. Bertrand, Petra Nijst, Lars Grieten, Joseph Dens, David Verhaert, Stefan Janssens, W. H. Wilson Tang, Wilfried Mullens
Journal: European Journal of Heart Failure (2014)
Adverse Drug Effects in Ambulatory Elderly Patients
Authors: Robert H Palmer
Journal: JAMA (2003)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal