tbuckley/cabot-search huggingface dataset:
Expression profiling of cytogenetically normal acute myeloid leukemia identifies MicroRNAs that target genes involved in monocytic differentiation
Authors: Mark Lutherborrow, Adam Bryant, Vivek Jayaswal, David Agapiou, Catalina Palma, Yee Hwa Yang, David D.F. Ma
Journal: American Journal of Hematology (2010)

MicroRNAs are short ribonucleic acids (RNAs) that play an important role in many aspects of cellular biology such as differentiation and apoptosis, due to their role in the regulation of gene expression. Using microRNA microarrays, we characterized the microRNA gene expression of 27 patients with acute myeloid leukemia (AML) with normal cytogenetics, focusing on the microRNAs differentially expressed between the M1 and M5 French-American-British (FAB) subtypes. An accurate delineation of these two AML entities was observed based on the expression of 12 microRNAs. We hypothesized that these microRNAs may potentially be involved in the differentiation block of M1 blasts and consequently monocytic differentiation. Using publically available mRNA data and microRNA target prediction software, we identified several key myeloid factors that may be targeted by our candidate microRNAs. The expression changes of the candidate microRNAs during monocytic differentiation of AML cell lines treated with Vitamin D and phorbol 12-myristate 13-acetate were examined. All six candidate microRNAs were significantly down-regulated over the time course by quantitative reverse transcriptase polymerase chain reaction suggesting a link between these microRNAs and monocytic differentiation. To further characterize these microRNAs, we confirmed by luciferase assays that these microRNA target several key myeloid factors such as MAFB, IRF8, and KLF4 identifying a possible mechanism for the control of differentiation by these microRNAs.
Urinary cyclic guanosine monophosphate as an indicator of experimental congestive heart failure in rats
Authors: J.-B. Michel, J.-J. Mercadier, F.-X. Galen, R. Urbain, J.-C. Dussaule, M. Philippe, P. Corvol
Journal: Cardiovascular Research (1990)

Journal Article Urinary cyclic guanosine monophosphate as an indicator of experimental congestive heart failure in rats Get access Jean-Baptiste Michel, Jean-Baptiste Michel Correspondence to: Professor Zehr Search for other works by this author on: Oxford Academic PubMed Google Scholar Jean-Jacques Mercadier, Jean-Jacques Mercadier Search for other works by this author on: Oxford Academic PubMed Google Scholar Frangois-Xavier Galen, Frangois-Xavier Galen Search for other works by this author on: Oxford Academic PubMed Google Scholar Rémi Urbain, Rémi Urbain Search for other works by this author on: Oxford Academic PubMed Google Scholar Jean-Claude Dussaule, Jean-Claude Dussaule Search for other works by this author on: Oxford Academic PubMed Google Scholar Monique Philippe, Monique Philippe Search for other works by this author on: Oxford Academic PubMed Google Scholar Pierre Corvol Pierre Corvol Search for other works by this author on: Oxford Academic PubMed Google Scholar Cardiovascular Research, Volume 24, Issue 11, November 1990, Pages 946–952, https://doi.org/10.1093/cvr/24.11.946 Published: 01 November 1990 Article history Received: 25 September 1989 Accepted: 20 June 1990 Published: 01 November 1990
Genome-wide ancestry association testing identifies a common European variant on 6q14.1 as a risk factor for asthma in African American subjects
Authors: Dara G. Torgerson, Daniel Capurso, Elizabeth J. Ampleford, Xingnan Li, Wendy C. Moore, Christopher R. Gignoux, Donglei Hu, Celeste Eng, Rasika A. Mathias, William W. Busse, Mario Castro, Serpil C. Erzurum, Anne M. Fitzpatrick, Benjamin Gaston, Elliot Israel, Nizar N. Jarjour, W. Gerald Teague, Sally E. Wenzel, José R. Rodríguez-Santana, William Rodríguez-Cintrón, Pedro C. Avila, Jean G. Ford, Kathleen C. Barnes, Esteban G. Burchard, Timothy D. Howard, Eugene R. Bleecker, Deborah A. Meyers, Nancy J. Cox, Carole Ober, Dan L. Nicolae
Journal: Journal of Allergy and Clinical Immunology (2012)
NUT Midline Carcinoma in Elderly Patients
Authors: Takatsugu Kawase, Go Naka, Kazuo Kubota, Baku Sakashita, Yuichiro Takeda
Journal: Clinical Nuclear Medicine (2015)

Nuclear protein in testis (NUT) midline carcinoma is a rare disease that generally arises in adolescents and young adults. However, we encountered a rare NUT midline carcinoma case in an elderly patient. 18F-2-fluoro-2-deoxyglucose positron emission tomography/computed tomography (PET/CT) studies were performed before and during the treatment course. In this case, the initial PET/CT study revealed locoregional hypermetabolism in the mediastinal lesion. After then, the interim PET/CT study indicated a clear diminishing response to the initial treatment, whereas the residual masses were morphologically observable. Nuclear imaging may allow visualization of the therapeutic effect of antineoplastic therapies in both young and elderly patients.
Abstract 3347: Enrichment of a CD44+/CD24- putative cancer stem cell population drives tumor progression and growth factor independence in a mouse model of postmenopausal breast cancer
Authors: Sarah M. Smith, Lucia J. Chiao, Crystal D. Salcido, Lyuba Varticovski, Stephen D. Hursting
Journal: Cancer Research (2010)

Abstract MMTV-Wnt-1 transgenic mice develop heterogeneous mammary tumors that accurately recapitulate human basal-like breast cancer. Additionally, targeted alterations in the Wnt signaling pathway in mammary epithelial cells preferentially induce mammary cancers from progenitor cells. Therefore, we hypothesized that MMTV-Wnt-1 mammary tumors harbor cells with cancer stem cell characteristics. To test this hypothesis, we characterized (in vitro and in vivo) two newly generated, clonal mammary epithelial cell lines (WA4 and WG4) from MMTV-Wnt-1 transgenic mouse tumors. The cell lines were analyzed using flow cytometry for CD44 and CD24 cell surface markers (a CD44+/CD24- profile is indicative of putative human and murine mammary cancer stem cells), mammosphere formation (low density seeding on non-adherent plates in stem-cell media), in vitro scratch assay (to measure wound healing), and by an in vitro Matrigel invasion chamber assay (to quantitate cell invasion). Finally, unsorted WA4 and WG4 cell lines were transplanted into syngeneic mammary fat pads of female ovariectomized (to model the postmenopausal state) C57BL/6 mice (1×10^7 cells/mouse; n=5/cell line), and tumor burden was assessed after 3 weeks. Tumors were analyzed by qRT-PCR and immunohistochemistry (IHC) for pathological and genetic markers of progression. Flow cytometric analysis demonstrated that the percentage of CD44+/CD24- cells was 62.2% in the WA4 line and 2.4% in the WG4 line. Serum starvation enriched the WA4 line for CD44+/CD24- cells (from 62.2% to 82.0%), without altering the composition of the WG4 line. Approximately 30% of unsorted WA4 cells, but &amp;lt;1% of unsorted WG4 cells, formed mammospheres. Additionally, the WA4 line showed increases in wound healing by scratch assay and significant increases in invasion (226-fold increase versus WG4 cells after 30 hours). In vivo, the WA4 cell line was associated with larger, more aggressive tumors on average (+/− SD) than the WG4 line (2.09 +/− 0.68 g and 0.03 +/− 0.02 g, respectively, p&amp;lt;0.0001). WA4 tumors were characterized by increased cellular proliferation, microvascular proliferation, and a basal appearance lacking ductal structures. WA4 tumors also demonstrated a loss of ERα/β expression (qRT-PCR), lacked IGF1-R activation (by IHC), and showed an increase in Wnt-1 progenitor signaling (qRT-PCR). In conclusion, MMTV-Wnt-1 transgenic mouse mammary tumors harbor a CD44+/CD24- putative cancer stem cell population, and an enrichment of this population corresponds with a more aggressive tumor phenotype in a mouse model of postmenopausal breast cancer. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 101st Annual Meeting of the American Association for Cancer Research; 2010 Apr 17-21; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2010;70(8 Suppl):Abstract nr 3347.
Dominant-negative Ikaros cooperates with BCR-ABL1 to induce human acute myeloid leukemia in xenografts
Authors: A P A Theocharides, S M Dobson, E Laurenti, F Notta, V Voisin, P-Y Cheng, J S Yuan, C J Guidos, M D Minden, C G Mullighan, E Torlakovic, J E Dick
Journal: Leukemia (2014)
Treatment of plasma refractory thrombotic thrombocytopenic purpura with protein A immunoabsorption
Authors: Thomas G. Gaddis, Troy H. Guthrie, Mary Jo Drew, Mervyn Sahud, Robert B. Howe, Abraham Mittelman
Journal: American Journal of Hematology (1997)

The objective of this study was to assess the effect of protein A immunoabsorption in terms of response rate and toxicities in patients with classical thrombotic thrombocytopenic purpura (TTP) refractory to therapeutic plasma exchange. The study included nine females and one male with a diagnosis of classical TTP treated at multiple university hospital centers with protein A immunoabsorption (PAI) after having failed plasma exchange. The 10 patients had an age range 17-62 years. Prior to PAI, the patients had failed to respond to a mean of 15 (range 6-39) therapeutic plasma exchanges. Three patients had previous episodes of TTP. Evaluation for response to PAI included serial measurements of serum creatinine, lactate dehydrogenase (LDH), hemoglobin, hematocrit, and platelet count before, during, and up to 18 months post-PAI treatment. Seven of 10 study patients had resolution of their TTP. Six of the patients required six or fewer therapeutic PAIs and one required 12 treatments. All responding patients had evidence of improvement by the third PAI treatment. Three patients demonstrated no response to PAI, with two patients expiring from complications of TTP and one patient demonstrating a complete response to a subsequent therapy. No significant toxicity was noted with the use of PAI in this setting. Protein A immunoabsorption in patients with classical TTP refractory to plasma exchange can produce durable complete remissions and warrants comparative studies. Am. J. Hematol. 55:55-58, 1997. © 1997 Wiley-Liss, Inc.
Structure, use, and validation of the IEUBK model.
Authors: M H Mickle
Journal: Environmental Health Perspectives (1998)

The potential impact of the effects of lead in children is a major concern. Although measurements of lead concentration can be made in a geographic area, it is difficult to predict the effects of this exposure that involve complicated biologic functions. Dynamic mathematical models that can be simulated on a digital computer provide one method of analysis to facilitate the prediction process. The integrated exposure uptake biokinetic (IEUBK) model is a dynamic mathematical model that has been discretized for execution on a digital computer. This paper is concerned with the general difficulties in validating a dynamic model of this type. A number of the general pitfalls of validating a model of this type are presented. The illustrations are of a general nature not requiring an understanding of the physiologic effects of lead on children. The concept of validating a model by comparing results to historical data is discussed. A comparison is made with traditional modeling efforts having this form of dynamic model. Also included are general mathematic concepts illustrating potential difficulties with intuitive analyses in calibrating a dynamic model.
THE RÔLE OF THE RETICULO-ENDOTHELIAL SYSTEM IN IMMUNITY
Authors: C. W. Jungeblut, J. A. Berlot
Journal: The Journal of Experimental Medicine (1926)

1. Following massive doses of India ink injected intravenously into guinea pigs before a subcutaneous injection of diphtheria toxin-antitoxin mixture, no antitoxin was found in the blood serum for 3 weeks, as indicated by intracutaneous tests, whereas an appreciable amount could be detected in non-blocked, immunized control animals. 2. During the 4th week following immunization, the titer of the serum of blocked animals equaled that of non-blocked controls within the limits of the intracutaneous test dose. 3. The smaller doses of India ink used in these experiments, given before immunization, had no stimulating effect on the production of diphtheria antitoxin but, on the contrary, also inhibited the appearance of this antibody, although to a less extent.
EFFECT OF DRY HEAT ON THE BLOOD COUNT IN ANIMALS
Authors: James B. Murphy, Ernest Sturm
Journal: The Journal of Experimental Medicine (1919)

Animals subjected to dry heat for a short period show a sharp fall in the total white blood count, both the polymorphonuclear leucocytes and the lymphocytes taking part in the fall. Following this there is a slow recovery on the part of the polymorphonuclear leucocytes, which generally require several weeks to regain their normal number. The lymphocytes rise rapidly after the initial fall and continue to rise for 2 or 3 weeks. This increase often amounts to a gain of over 200 to 300 per cent above the normal count for the animal. The observations were made on mice, rats, and guinea pigs. The circulating lymphocytes during the more active stage of stimulation after heating show numerous examples of amitotic division.
Analysis of Th2-specific chemokines in exhaled breath condensate from asthmatic children*1
Authors: T.F. Leung, G.W.K. Wong, F.W.S. Ko, C.Y. Li, C.K. Wong, E. Yung, C.W.K. Lam, T.F. Fok
Journal: Journal of Allergy and Clinical Immunology (2004)
Physical Examination for Exclusion of Hemodynamically Important Right Ventricular Infarction
Authors: LOUIS J. DELL'ITALIA
Journal: Annals of Internal Medicine (1983)

Fifty-three consecutive patients with inferior myocardial infarction were evaluated prospectively, by physical examination and right heart catheterization within 36 hours of the onset of symptoms, to determine whether physical findings can separate such patients into those with and without associated right ventricular infarction. Hemodynamic findings consistent with right ventricular infarction were defined as right atrial pressure of 10 mm Hg or greater and a right atrial: pulmonary artery wedge pressure ratio of 0. 80 or greater. Eight patients (Group 1) had hemodynamic evidence of right ventricular infarction, whereas 45 patients (Group 2) did not meet these criteria. Group 1, compared with Group 2, had a lower cardiac index (1.8 ± 0.3 versus 2.6 ± 0.6 L/min · m2, p < 0.001), and a lower right ventricular stroke work index (4.1 ± 3.6 versus 7.3 ± 3.2g · m/m2, p < 0.05). An elevated jugular venous pressure of 8 cm H2O or more was seen in 7 of 8 Group 1 and 14 of 45 Group 2 patients (p < 0.01). In addition, a Kussmaul's sign, substantiated by hemodynamic findings, was seen in all 8 Group 1 and in no Group 2 patients (p < 0.001). The absence of both an elevated jugular venous pressure and a Kussmaul's sign in patients with inferior myocardial infarction makes the presence of a hemodynamically significant right ventricular infarction highly unlikely.
SHOULD HEMOGLOBIN, SYSTOLIC BLOOD PRESSURE AND PRO B-TYPE NATRIURETIC PEPTIDE BE PART OF STROKE RISK SCORES AFTER AN ACUTE CORONARY SYNDROME?
Authors: Joana Rodrigues Neves, Raquel Ferreira, Anabela Gonzaga, Jos- M. Bastos, Jos- A. Santos
Journal: Journal of the American College of Cardiology (2014)
Hydrogels: Pd‐Porphyrin‐Cross‐Linked Implantable Hydrogels with Oxygen‐Responsive Phosphorescence (Adv. Healthcare Mater. 6/2014)
Authors: Haoyuan Huang, Wentao Song, Guanying Chen, Justin M. Reynard, Tymish Y. Ohulchanskyy, Paras N. Prasad, Frank V. Bright, Jonathan F. Lovell
Journal: Advanced Healthcare Materials (2014)

J. F. Lovell and team present a new strategy to create a biocompatible implantable hydrogel for non-invasive oxygen sensing. On page 891, a tetracarboxy porphyrin is reacted with PEG diamines under conditions that result in nearly quantitative dye incorporation. Polyamide is formed with millimolar porphyrins exhibiting near infrared phosphorescence, ideal for in vivo detection. The spatially constraining mesh of the PEG-porphyrin matrix prevents porphyrin aggregation that would normally occur at such dye concentrations and attenuate the phosphorescence. The hydrogel can be implanted in mice for weeks without signs of toxicity, signal loss or polymer degradation, and could non-invasively detect changes in subcutaneous oxygen levels via transdermal phosphorescence detection.
FATAL CASE of PEMPHIGUS ACUTUS MALIGNUS
Authors: W. J. Caie
Journal: BMJ (1903)

with mineral waters, lemon water, tea, milk, custards, cream, barley water, and fine porridge.Thirdly, as my tests establish, neither the acid juice of the stomach nor the alkaline contents of the bowels will interfere with the action of the drag; and, fourthly, this action reaches down to the lowest portion of bowel, and therefore I am justified in looking on the drag as a suitable means for local treatment within the intestine. Coming now to the special indications inEnteric 1ever, V. myrtillus can claim to keep the intestine aseptic (as far as B. typh. is concerned) to prevent reabsorption and reinfection, and thus prevent and cut short the duration of the infection;
Motor representations: One or many?
Authors: M. Jeannerod
Journal: Behavioral and Brain Sciences (1996)

Abstract Two issues have been raised. The first concerns whether consciousness is attached to a given type of action. It is argued that purposive actions are represented before being executed and that motor representations can either remain implicit or become explicit according to the task. The second issue concerns whether or not mental imagery of action is independent from action. Recent evidence showing the commonality of neural mechanisms for motor imagery and action, respectively, goes against the idea of independent processes.
Electrocardiogram interpretation in acute coronary syndromes: To be improved?
Authors: Alexandre Berger, Jean-Marc Meier, Jean-Christophe Stauffer, Philippe Eckert, Jurg Schlaepfer, Eric Eeckhout, Bertrand Yersin, Lukas Kappenberger, Jean-Blaise Wasserfallen
Journal: Journal of the American College of Cardiology (2003)
Pseudomonas Colonization in Cystic Fibrosis
Authors: Lucas L. Kulczycki
Journal: JAMA (1978)

We investigated the role of<i>Pseudomonas aeruginosa</i>colonization in the respiratory tracts of cystic fibrosis (CF) patients to relate the effect of this colonization to progression of bronchial airway pathologic conditions and to the patients' clinical progress, and to identify predisposing factors to persistence of<i>P aeruginosa</i>colonization and bronchial tree damage. Half of 160 CF patients studied had persistent<i>P aeruginosa</i>respiratory tract colonization; the other half had none.<i>Pseudomonas aeruginosa</i>seems to have an exclusive propensity for the respiratory tract and may appear at any age. Treatment with antibiotics, including aminoglycosides, failed to eradicate<i>P aeruginosa</i>. The continuous use of antibiotics seemed to contribute to the persistence of<i>P aeruginosa</i>and the appearance of mucoid strains of<i>P aeruginosa</i>. (<i>JAMA</i>240:30-34, 1978)
Clinicopathologic Characteristics of Premalignant and Malignant Melanocytic Lesions of the Conjunctiva
Authors: Frederick A. Jakobiec, Robert Folberg, Takeo Iwamoto
Journal: Ophthalmology (1989)

Primary acquired melanosis (PAM), a disease that affects mostly middle-aged white patients, is predominantly a proliferative condition of the melanocytes that normally populate the conjunctival epithelium. Primary acquired melanosis without atypia (low risk for the development of melanoma) is typically created by increased numbers of melanocytes restricted to the basilar region of the epithelium without nuclear hyperchromasia or prominence of the nucleoli. Primary acquired melanosis with atypia, a formal precursor of melanoma, is characterized by the proliferation of small polyhedral cells, spindle cells, large dendritiform melanocytes, or epithelioid cells that may: remain restricted to the basilar region (basilar nests); form nests at all levels of the epithelium; spread individually to all levels of the epithelium (pagetoid extension); or proliferate in a sheet-like fashion approximating a melanoma in situ. Lesions composed of epithelioid cells or exhibiting intraepithelial pagetoid extension have, respectively, a 75 or 90% chance of eventuating in invasive melanoma. Primary acquired melanosis in an adult should not be confused with "a junctional nevus", which is almost always restricted to childhood. Invasive melanomas measuring less than 0.8 mm in thickness tend not to be associated with metastases; the tumor cells may be small polyhedral (in which case confusion with a compound nevus often arises), epithelioid, spindled, or ballooned. Nodules composed of spindle cells in part or in toto tend to have less metastatic potential at a given thickness measurement than comparable nodules composed of epithelioid or polyhedral cells. The clinical features, electron microscopic findings, and biologic principles underwriting clinical management are also presented.
Celiac Disease
Authors: Stefano Guandalini, Asaad Assiri
Journal: JAMA Pediatrics (2014)

Triggered by the ingestion of gluten in genetically predisposed individuals, celiac disease is the most common genetically based food intolerance in the world, with a prevalence among approximately 1% of the general population. This enteropathy may appear at any age and is characterized by a wide variety of clinical signs and symptoms that go well beyond the gastrointestinal tract. In young children, gastrointestinal presentations are common and include chronic diarrhea, failure to thrive, and abdominal distention; however, extraintestinal manifestations are becoming increasingly more common. They include numerous conditions such as dermatitis herpetiformis, anemia, dental enamel hypoplasia, recurrent oral aphthae, short stature, osteoporosis, arthritis, neurologic problems, unexplained elevation of transaminase levels, and female infertility. Therefore, diagnosing celiac disease requires a high degree of suspicion, followed by correct screening and a confirmatory test with an intestinal biopsy. After diagnosis, a strict gluten-free diet must be followed, which in most cases will bring a marked improvement of symptoms. However, there are important compliance and quality-of-life problems, especially in adolescents.