tbuckley/cabot-search huggingface dataset:
Localisation and characterisation of substance P binding to human synovial tissue in rheumatoid arthritis.
Authors: D A Walsh, P I Mapp, J Wharton, R A Rutherford, B L Kidd, P A Revell, D R Blake, J M Polak
Journal: Annals of the Rheumatic Diseases (1992)

The neuropeptide substance P is found in perivascular and free unmyelinated nerve fibres in human synovial tissue. Quantitative receptor autoradiography was used to show specific, high affinity (Kd = 0.75 (0.21), nmol/l (mean (standard error of the mean)), low capacity (Bmax = 27.8 (7.9) amol/mm2) binding sites for substance P Bolton Hunter-labelled with iodine-125 localised to vascular endothelial cells in human synovial tissue. The binding could be saturated, was reversible, and was dependent on the magnesium concentration. Unlabelled substance P and neurokinin A competitively inhibited specific binding with 50% inhibition at concentrations of 1.25 (0.21) and 175 (29) nmol/l respectively. Neurokinin B (mumol/l) and calcitonin gene related peptide (1 mumol/l) did not inhibit binding. These binding sites show characteristics of the neurokinin 1 tachykinin receptor subtype. This provides further evidence that substance P may play a part in the vascular control of human synovium and may influence inflammatory processes in joints.
Cross-reactivity studies of a new group 2 allergen from the dust mite Glycyphagus domesticus , Gly d 2, and group 2 allergens from Dermatophagoides pteronyssinus, Lepidoglyphus destructor , and Tyrophagus putrescentiae with recombinant allergens
Authors: Guro Gafvelin, Eva Johansson, Anna Lundin, Alisa M. Smith, Martin D. Chapman, David C. Benjamin, Urszula Derewenda, Marianne van Hage-Hamsten
Journal: Journal of Allergy and Clinical Immunology (2001)
Stab Wounds Associated With Terrorist Activities in Israel
Authors: Jaafar El-Murad
Journal: JAMA (1997)

<h3>To the Editor.</h3> —I am amazed that a respected journal such as yours chose to publish such an ill-researched and poorly thought-out article as the one by Dr Hanoch and colleagues.<sup>1</sup>It is absurd to link the activities of the hashshashins with social and political frustration on the one hand and the Islamic concept of martyrdom on the other. The hashshashins were indeed an obscure sect, funded in part by their specialization in a form of contract killing. This was usually carried out under the influence of hashish—hence, the name—which both reduced any inhibitions on the part of the killer and provided the incentive, in the form of a further supply of the drug. Clearly this has nothing to do with the concept of<i>sha'hid</i>, which is all about earning forgiveness and hence paradise through sacrificing oneself in war against the enemies of the state. Significantly, one becomes a<i>sha'hid</i>by dying,
Abstract P1-13-08: Arthralgia and changes in serum levels of IGF-I, its binding protein and estrogen in breast cancer patients on endocrine agents
Authors: A Lintermans, K Van Asten, H Wildiers, R Paridaens, K Leunen, A Smeets, F Amant, M-R Christiaens, J Verhaeghe, P Vermeersch, D Vanderschueren, P Neven
Journal: Cancer Research (2013)

Abstract Objective Aromatase inhibitors (AIs) frequently induce or enhance musculoskeletal problems, also known as the AI-induced musculoskeletal syndrome (AIMSS). Underlying mechanisms are unknown, likely multiple and induced by low estrogen levels. We hypothesized a role for the growth hormone (GH)/insulin-like growth factor I (IGF-I) axis (Lintermans et al, Ann of Oncol 2011). Recently, Gallicchio et al. (J Cancer Res Clin Oncol 2013) confirmed our hypothesis. Here we report the effect of tamoxifen and AIs on AIMSS, IGF-I, its binding protein and estrogen levels from a prospective study. Material &amp; Methods In this prospective cohort study postmenopausal women with an early breast cancer scheduled to start adjuvant endocrine therapy with any of the third generation AIs or tamoxifen were included. After providing informed consent, a rheumatologic questionnaire was completed and serum was collected. AI-induced musculoskeletal pain was defined as an increase in joint or muscle pain relative to baseline; AIMSS presence was defined as the presence of ≥ 3 out of five features (arthralgia, myalgia, joint stiffness, tingling, carpal tunnel syndrome). IGF-I levels were determined in batch with an inhouse radio-immunoassay; levels of IGF binding protein 3 (IGFBP-3) with a commercial EASIA from DiaSource. A sensitive liquid chromatography dual mass spectrometry was used for assessment of estradiol (E2) and estrone (E1) values, with a limit of quantification of 1.3 and 1.2 ng/l, respectively. SHBG levels were determined with the Roche Modular E170 analyzer. Re-evaluation was done after 3, 6 and 12 months of therapy. Results 84 patients started on tamoxifen (n = 42) or an AI (n = 42; anastrozole n = 6, letrozole n = 36). In the AI group, 4 patients discontinued due to AIMSS. In the tamoxifen group, 1 patient developed a deep vein thrombolic event and discontinued tamoxifen therapy. In all BMI categories, AI and not tamoxifen decreased E1 and E2 levels below limit of quantification from month 3 onwards. SHBG values dropped on AI while they increased on tamoxifen. AI therapy resulted in elevated IGF-I and IGF-I/IGFBP-3 ratio levels, whereas tamoxifen users had a decrease. AI-induced musculoskeletal symptoms were characterized by a higher increase from baseline in IGF-I levels and IGF-I/IGFBP-3 ratio than AI users without any complaints. Patients experiencing AIMSS showed a significant decrease in IGFBP-3 levels (p = 0.0007) and an increase in IGF-I/IGFBP-3 ratio (p = 0.07) compared to patients without AIMSS. This divergence was most pronounced at 3 months following AI start. Conclusion These findings provide preliminary evidence that AI-induced musculoskeletal symptoms are associated with changes in the GH/IGF-I axis. Citation Information: Cancer Res 2013;73(24 Suppl): Abstract nr P1-13-08.
Differences in asthma risk factors due to influences of acculturation in a birth cohort of New York City-born Puerto Ricans*1
Authors: G.L. Chew, L.M. Acosta, D. Acevedo-García, D.E. Cortés, A. Divjan, J.C. Correa, J.K. Fagan, R.B. Mellins, M.S. Perzanowski
Journal: Journal of Allergy and Clinical Immunology (2004)
PREGNANCY AND LABOR COMPLICATED BY DISEASES AND INJURIES OF THE SPINAL CORD
Authors: FREDERICK L. GOOD
Journal: JAMA (1924)

On the evening of Oct. 7, 1923, there was admitted to the Cambridge City Hospital, Cambridge, Mass., a woman, aged 21, who had been shot by her husband a short while before. Three bullets had entered her body; one, about 1 inch below the right clavicle at a point midway between the acromion process and the sternum; another, 2 inches below the right shoulder joint in the anterior axillary line; and still another, at about the seventh dorsal vertebra in back and about 1 inch to the left of the median line. The patient was at the time about six and one-half months pregnant. She had given birth to two other children, both deliveries being normal; the older child aged 2 years, and the younger aged 1 year. The patient was well developed and nourished, conscious and rational, apparently in pain, and bleeding from wounds in the right shoulder and
A new device for the treatment of hyperhidrosis by iontophoresis
Authors: K. MIDTGAARD
Journal: British Journal of Dermatology (1986)

A new device for the treatment of hyperhidrosis by iontophoresis is described. Twenty-five patients have so far been treated, six with hyperhidrosis of the palms, 13 with hyperhidrosis of the soles and six with axillary hyperhidrosis. In 21 cases there was an excellent result. The effect of the treatment usually lasted for several weeks. Maintenance treatment every 4-6 weeks was found to be required.
Stress' route through brain to heart
Authors: William Check
Journal: JAMA (1978)

Neuroanatomic pathways that may mediate the effects of stress on the cardiovascular system are finally beginning to be defined. "People have talked about the contribution of stress to heart attacks for a long time," says David Cohen, PhD, professor of physiology and director of neuroscience at the University of Virginia School of Medicine. "The mapping of these pathways gives greater credibility to claims that stress is associated with cardiovascular dynamics." Mapping also provides a target for experiments into the mechanism of stress-related heart attacks and ventricular fibrillation (VF) and offers the potential of therapeutic intervention. One important future application of such studies: the problem of sudden death. Separate but related investigations were reported at the recent meeting of the Society for Neuroscience by Cohen and colleagues and by James Skinner, PhD, associate professor in the Department of Neurology and the Neuroscience Program at Baylor College of Medicine, and co-workers. The
FcγR-stimulated activation of the NADPH oxidase: phosphoinositide-binding protein p40phox regulates NADPH oxidase activity after enzyme assembly on the phagosome
Authors: Wei Tian, Xing Jun Li, Natalie D. Stull, Wenyu Ming, Chang-Il Suh, Sarah A. Bissonnette, Michael B. Yaffe, Sergio Grinstein, Simon J. Atkinson, Mary C. Dinauer
Journal: Blood (2008)
Effects of Nicotinic Acid Therapy on Plasma High Density Lipoprotein Subfraction Distribution and Composition and on Apolipoprotein A Metabolism
Authors: James Shepherd, Christopher J. Packard, Josef R. Patsch, Antonio M. Gotto, O. David Taunton
Journal: Journal of Clinical Investigation (1979)

This report describes the effects of pharmacologic doses (3 g/d) of nicotinic acid on the plasma distribution and chemical composition of the high density lipoprotein (HDL) subfractions HDL(2) and HDL(3) and examines the influence of the drug on the metabolism of the major HDL apoproteins, apolipoproteins A-I (ApoA-I) and A-II (Apo-II). The drug lowered plasma cholesterol (15%, P < 0.05) and triglyceride (27%, P < 0.01); the former effect a result of a fall in the amount of cholesterol associated with very low density lipoproteins (31%, P < 0.02) and low density lipoproteins (36%, P < 0.02). Conversely, it raised plasma HDL cholesterol (23%, P < 0.05) and increased (by 345%) the plasma HDL(2):HDL(3) ratio. The latter derived from an absolute increment (646%) in circulating HDL(2), coupled with a fall (47%) in HDL(3). This change was not associated with major alterations in the overall cholesterol (free and esterified), triglyceride, phospholipid, or protein content of the subfractions; however, it was accompanied by substantial changes in their protein composition. In particular, the molar ratio of ApoA-I:ApoA-II in HDL(3) declined from 2.7:1 to 2.1:1 during nicotinic acid treatment.Significant perturbations of ApoA-I and ApoA-II metabolism accompanied the drug-induced HDL subfraction redistribution. Specifically, the plasma concentration of ApoA-I rose by 7% (P < 0.05) because of a decrease in its fractional catabolic rate. Moreover, whereas before treatment 6 and 94% of the plasma ApoA-I circulated with HDL(2) and HDL(3), after commencement of nicotinic acid therapy this distribution became 49 and 51% in HDL(2) and HDL(3), respectively. ApoA-II was found mainly in HDL(3), both before and during nicotinic acid treatment. Administration of the drug caused a 14% reduction in its plasma concentration (P < 0.05), which derived principally from a fall (22%, P < 0.01) in its synthetic rate. These data suggest that the effects of nicotinic acid on the HDL subfraction distribution may be mediated via (a) net transfer of ApoA-I from HDL(3) to HDL(2) and (b) a reduction in ApoA-II synthesis. Our present understanding of the association between HDL and atherosclerosis indicates that such changes may have prophylactic value in the prevention of coronary artery disease.
TCT-459 Long-Term Outcome in Patients with ST-Elevation Myocardial Infarction and Infarct-Related Coronary Artery Ectasia treated with Primary Percutaneous Coronary Intervention
Authors: Alfonso Campanile, Fabiola Sozzi, Dario Consonni, Federico Piscione, Paolo Sganzerla, Ciro Indolfi, Amerigo Stabile, Angela Migliorini, Roberto Ferraresi, Giacomo Boccuzzi, Gian Battista Danzi
Journal: Journal of the American College of Cardiology (2012)
Ventilatory Efficiency during Exercise in Healthy Subjects
Authors: Xing-Guo Sun, James E. Hansen, Nuria Garatachea, Thomas W. Storer, Karlman Wasserman
Journal: American Journal of Respiratory and Critical Care Medicine (2002)

When evaluating dyspnea in patients with heart or lung disease it is useful to measure the quantity of ventilation needed to eliminate metabolically produced CO2 (i.e., the ventilatory efficiency). Mathematically, the relationship between ventilation (VE) and CO2 output is determined by the arterial CO2 pressure and the physiologic dead space-tidal volume ratio. We decided to determine how age, sex, size, fitness, and the type of ergometer influenced ventilatory efficiency in normal subjects. Three methods were compared for expressing this relationship: (1) the VE versus CO2 output slope below the ventilatory compensation point, commonly used by cardiologists for estimating the severity of heart failure; (2) the VE/CO2 output ratio at the anaerobic threshold, commonly used by pulmonologists; and (3) the lowest VE/CO2 output ratio during exercise, the latter parameter not previously reported. We studied 474 healthy adults, between 17 and 78 years of age during incremental cycle and treadmill cardiopulmonary exercise tests at three test sites, correcting the total VE for the equipment dead space. The lowest VE/CO2 output ratio was insignificantly different from the ratio at the anaerobic threshold, less variable than that for the slope relationship, and unaffected by the site, ergometer, and gas exchange measurement systems. The regression equation for the lowest VE/CO2 output ratio was 27.94 + 0.108 x age + (0.97 = F, 0.0 = M) - 0.0376 x height, where age is in years and height is in centimeters. We conclude that the lowest VE/CO2 output ratio is the preferred noninvasive method to estimate ventilatory inefficiency.
Development of a Multiplexed Tumor-Associated Autoantibody-Based Blood Test for the Detection of Non–Small Cell Lung Cancer
Authors: Erin C. Farlow, Kalpa Patel, Sanjib Basu, Bao-Shiang Lee, Anthony W. Kim, John S. Coon, L. Penfield Faber, Philip Bonomi, Michael J. Liptay, Jeffrey A. Borgia
Journal: Clinical Cancer Research (2010)

Non-small cell lung cancer (NSCLC) has an overall 5-year survival of <15%; however, the 5-year survival for stage I disease is over 50%. Unfortunately, 75% of NSCLC is diagnosed at an advanced stage not amenable to surgery. A convenient serum assay capable of unambiguously identifying patients with NSCLC may provide an ideal diagnostic measure to complement computed tomography-based screening protocols.Standard immunoproteomic method was used to assess differences in circulating autoantibodies among lung adenocarcinoma patients relative to cancer-free controls. Candidate autoantibodies identified by these discovery phase studies were translated into Luminex-based "direct-capture" immunobead assays along with 10 autoantigens with previously reported diagnostic value. These assays were then used to evaluate a second patient cohort composed of four discrete populations, including: 117 NSCLC (81 T(1-2)N(0)M(0) and 36 T(1-2)N(1-2)M(0)), 30 chronic obstructive pulmonary disorder (COPD)/asthma, 13 nonmalignant lung nodule, and 31 "normal" controls. Multivariate statistical methods were then used to identify the optimal combination of biomarkers for classifying patient disease status and develop a convenient algorithm for this purpose.Our immunoproteomic-based biomarker discovery efforts yielded 16 autoantibodies differentially expressed in NSCLC versus control serum. Thirteen of the 25 analytes tested showed statistical significance (Mann-Whitney P < 0.05 and a receiver operator characteristic "area under the curve" over 0.65) when evaluated against a second patient cohort. Multivariate statistical analyses identified a six-biomarker panel with only a 7% misclassification rate.We developed a six-autoantibody algorithm for detecting cases of NSCLC among several high-risk populations. Population-based validation studies are now required to assign the true value of this tool for identifying early-stage NSCLC.
Minimal residual disease (MRD) analysis in the non-MRD-based ALL IC-BFM 2002 protocol for childhood ALL: is it possible to avoid MRD testing?
Authors: E Fronkova, E Mejstrikova, S Avigad, K W Chik, L Castillo, S Manor, L Reznickova, T Valova, K Zdrahalova, O Hrusak, Y Jabali, M Schrappe, V Conter, S Izraeli, C K Li, B Stark, J Stary, J Trka
Journal: Leukemia (2008)
Cutaneous leiomyomas (piloleiomyomas) in adult patients with human immunodeficiency virus infection
Authors: J. Kanitakis, E. Carbonnel, B. Chouvet, B. Labeille, A. Claudy
Journal: British Journal of Dermatology (2000)

Journal Article Cutaneous leiomyomas (piloleiomyomas) in adult patients with human immunodeficiency virus infection Get access J. Kanitakis, J. Kanitakis Department of Dermatology, Hôpital Ed. Herriot (Pav. R), 69437 Lyon cedex 03, France Search for other works by this author on: Oxford Academic Google Scholar E. Carbonnel, E. Carbonnel Department of Dermatology, Hôpital Ed. Herriot (Pav. R), 69437 Lyon cedex 03, France Search for other works by this author on: Oxford Academic Google Scholar B. Chouvet, B. Chouvet Department of Dermatology, Hôpital Ed. Herriot (Pav. R), 69437 Lyon cedex 03, France Search for other works by this author on: Oxford Academic Google Scholar B. Labeille, B. Labeille Department of Dermatology, Hospital of Valence, FranceE‐mail: kanitak@lyon151.inserm.fr Search for other works by this author on: Oxford Academic Google Scholar A. Claudy A. Claudy Department of Dermatology, Hôpital Ed. Herriot (Pav. R), 69437 Lyon cedex 03, France Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 143, Issue 6, 1 December 2000, Pages 1338–1340, https://doi.org/10.1046/j.1365-2133.2000.03925.x Published: 01 December 2000
Antidepressants and suicide
Authors: G. Isacsson, P. Holmgren, D. Wasserman, U. Bergman
Journal: BMJ (1995)

part of the table or of : 20 in total indicates that the person is in imminent danger and should not be left alone; 14-19 (high risk) indicates that another meeting should be fixed soon; 6-11 (moderate risk) indicates that another meeting should be fixed; and 1-5 (slight risk) or 0 in the first part of the table (no suicidal intent) indicates that the volunteer should hear the person out and let him or her go unless there are other reasons to meet again.Scoring table used to assess risk ofsuicide Choose onefigure to score suicideplan Chief indicator of immediate risk: Imminent sudden death 8 Imminent slow method of suicide 7 Future sudden death planned 6 Future slow method of suicide planned 5 Planning suicide "gamble" 4 Planning suicidal gesture 3 Definite suicidal thoughts but no plan 2 Toying vaguely with idea ofsuicide I No suicidal thoughts 0 Addpoinusfor every relevant item, mosdy the long termfactors Previous suicidal acts or gestures S 4 Recent broken relationship 3 Isolation.Rejection 3 (each) No hope.Loss offaith 3 (each) Depressive illness 3 Dependence on alcohol or drugs 2 Possession of means of suicide 2 Putting affairs in order 2 Over 60.Male.Ill.Chronic pain 1 (each)
THE CONSTRICTING INFLUENCE OF ADRENALIN UPON THE HUMAN CORONARY ARTERIES
Authors: Henry G. Barbour
Journal: The Journal of Experimental Medicine (1912)

1. Adrenalin causes a marked constriction of the human coronary artery, although it undoubtedly produces a relaxation in some mammals; e. g., calf, sheep, pig, etc. 2. The human coronary artery is probably provided with sympathetic vasoconstrictors. 3. If human blood-vessels are obtained in a warm condition within a few hours after death, they are often suitable for biological and pharmacological study.
Circulating Endothelial Progenitor Cells Do Not Contribute to Plaque Endothelium in Murine Atherosclerosis
Authors: Mette K. Hagensen, Jeong Shim, Troels Thim, Erling Falk, Jacob F. Bentzon
Journal: Circulation (2010)

Background— It has been reported that circulating endothelial progenitor cells (EPCs) home to and differentiate into endothelial cells after various kinds of arterial injury. By inference, EPCs are also proposed to be important in the most important arterial disease, atherosclerosis, but the evidence for this theory is not clear. In the present study, we assessed the contribution of circulating EPCs to plaque endothelium in apolipoprotein E–deficient (apoE −/− ) mice. Methods and Results— To investigate whether EPCs in the circulating blood are a source of plaque endothelial cells during atherogenesis, we examined plaques in lethally irradiated apoE −/− mice reconstituted with bone marrow cells from enhanced green fluorescent protein (eGFP) transgenic apoE −/− mice and plaques induced in segments of common carotid artery transplanted from apoE −/− mice into eGFP + apoE −/− mice. Among 4232 endothelial cells identified by a cell-type–specific marker (von Willebrand factor) and analyzed by high-resolution microscopy, we found only 1 eGFP + . Using the Y chromosome to track cells after sex-mismatched transplants yielded similar results. To investigate whether circulating EPCs are involved in plaque reendothelialization after plaque disruption and superimposed thrombosis, we produced mechanical plaque disruptions in carotid bifurcation plaques in old lethally irradiated apoE −/− mice reconstituted with eGFP + apoE −/− bone marrow cells and carotid bifurcation plaques transplanted from old apoE −/− mice into eGFP + apoE −/− mice. Only 1 eGFP + endothelial cell was found among 3170 analyzed. Conclusions— Circulating EPCs rarely, if ever, contribute to plaque endothelium in apoE −/− mice. These findings bring into question the prevailing theory that circulating EPCs play an important role in atherogenesis.
Composite polymorphisms in the ryanodine receptor 2 gene associated with arrhythmogenic right ventricular cardiomyopathy
Authors: H MILTING, N LUKAS, B KLAUKE, R KORFER, A PERROT, K OSTERZIEL, J VOGT, S PETERS, R THIELECZEK, M VARSANYI
Journal: Cardiovascular Research (2006)

Objective: Mutations in the cardiac ryanodine receptor (RYR2) gene have been reported to cause arrhythmogenic right ventricular cardiomyopathy (ARVC). The molecular mechanisms by which genetic modifications lead to ARVC are still not well understood.
Effect of Bilateral Nephrectomy and Kidney Transplantation on Hypertension in Man
Authors: WILLIEM J. KOLFF, SATORU NAKAMOTO, EUGENE F. POUTASSE, RALPH A. STRAFFON, JULIO E. FIGUEROA
Journal: Circulation (1964)

In conclusion, we consider that renal hypertension may have two components: a renal component and a renoprival component (fig. 6). Bilateral nephrectomy abolishes the renal component and leaves a renoprival hypertension that is sensitive to water and salt. Implantation of a kidney may cure the renoprival hypertension. Rejection of the graft may then be followed by a return of renal hypertension. Since the technique of transplantation of kidneys taken from cadavers is improving steadily, repeated nephrectomies and a second transplant become possible.
Practical Aspects of Oxalate Metabolism
Authors: Harold Jeghers, Rosemary Murphy
Journal: New England Journal of Medicine (1945)

Oxalate LithiasisUrinary lithiasis is a broad subject. There are a number of excellent general papers that are of considerable value for the purpose of orientation in this complex field.82 83 84 85 86 87 88 89 There has been an increasing interest in recent years in the pathogenesis of urinary calculi. Many factors, such as hyperparathyroidism, persistent hypercalcinuria, urinary-tract stasis, a persistently alkaline urine, infection of the urinary tract with urea-splitting organisms and prolonged recumbency, have been established as causes of phosphate calculi. Furthermore, the prevention of their recurrence and even their dissolution by chemical means have had some measure of success. By contrast, the pathogenesis . . .