tbuckley/cabot-search huggingface dataset:
Ventilator-associated pneumonia in surgical intensive care unit: Risk factors for mortality and survival period
Authors: Hisashi Shoji, Takahiro Takuma, Koichiro Yoshida, Yoshihito Niki
Journal: European Respiratory Journal (2011)

Objectives: The aim of this study was to reveal the prognostic factors of Ventilator-Associated Pneumonia (VAP) in the surgical ICU of Showa University Hospital in Tokyo.

Patients and methods: We reviewed 1629 cases administrated mechanical ventilation in surgical ICU from Apr,2006 to Dec,2010. In these 1629 cases, 46 patients were diagnosed VAP. We evaluated whether backgrounds, general conditions, laboratory data, chest radiographic features at the time of VAP onset and severity of VAP may contribute to the mortality or survival period.

Results: Twenty-three patients (50%) were dead. Multivariate analyses using significant (p<0.05) parameter in univariate analyses revealed different results, but bilateral pneumonia had significant differences in the both multivariate analyses of mortality and survival period (Table 1 & 2).

![Figure][1] 



Figure 1 shows Kaplan-Meier curves of radiographic findings and survival period.

![Figure][1] 



Conclusion: In this study, bilateral pneumonia had high mortality and was shorten survival period. We will present the other risk factors for mortality in this Annual Congress.

 [1]: pending:yes
Creamy Yellow Concretions in Axillary Hair
Authors: Lorena Barboza-Guadagnini, María Teresa Fernández-Figueras, Julio Bassas-Vila
Journal: JAMA Dermatology (2015)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Dermatology HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Dermatology journal
Patient-reported outcomes in psoriasis research and practice
Authors: M.F. Otuki, R.C. Reis, D. Cabrini, A.S. Prudente, C.D.S. Horinouchi, C.J. Correr
Journal: British Journal of Dermatology (2011)

Journal Article Patient‐reported outcomes in psoriasis research and practice Get access M.F. Otuki, M.F. Otuki Pharmacy Department State University of Ponta Grossa Ponta Grossa, Parana, Brazil Search for other works by this author on: Oxford Academic Google Scholar R.C. Reis, R.C. Reis Pharmacology Department Federal University of Parana Curitiba, Parana, Brazil Search for other works by this author on: Oxford Academic Google Scholar D. Cabrini, D. Cabrini Pharmacology Department Federal University of Parana Curitiba, Parana, Brazil Search for other works by this author on: Oxford Academic Google Scholar A.S. Prudente, A.S. Prudente Pharmacology Department Federal University of Parana Curitiba, Parana, Brazil Search for other works by this author on: Oxford Academic Google Scholar C.D.S. Horinouchi, C.D.S. Horinouchi Pharmacology Department Federal University of Parana Curitiba, Parana, Brazil Search for other works by this author on: Oxford Academic Google Scholar C.J. Correr C.J. Correr Pharmacy Department Federal University of Parana Av. Pref. Lothário Meissner 632 Jd Botânico, Curitiba Parana 80210‐170, Brazil Cassyano Januário Correr. E‐mail: cassyano@ufpr.br Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 165, Issue 6, 1 December 2011, Pages 1361–1362, https://doi.org/10.1111/j.1365-2133.2011.10469.x Published: 01 December 2011
Abstract 886: Mitochondrial Oxidative Stress Negatively Impacts Endothelial Function in the Metabolic Syndrome
Authors: Takahiko Kiyooka, Petra Rocic, Glenn Wilson, Inna Shokolenko, William M Chilian
Journal: Circulation (2007)

The prediabetic metabolic syndrome (pdMS) is characterized by modest to moderate impairments of endothelial function that progress to severe dysfunction as the disease evolves to Type II diabetes. Although in diabetes mitochondrial oxidative stress (mtOxStress) is postulated to contribute to diabetic cardiomyopathy, a link between mtOxStress and endothelial dysfunction in diabetes or in the pdMS is undetermined. Because mitochondrial (mt) DNA fragmentation occurs with mtOxStress, and such effects will alter expression of key mitochondrial proteins involved with energy production and cell viability, we hypothesized that in the pdMS, mtOxStress leading to mtDNA fragmentation, alters endothelial function impairing endothelium-dependent dilation. To test this, lean (LN, n = 6) and obese (OB, n = 11) Zucker fatty rats (model of pdMS) were instrumented with a jugular catheter to deliver recombinant proteins (mt-tat-ExoIII [0.2 ug/g/day]: TAT sequence to enable intracellular delivery, a mt-localization sequence, and the bacterial exonuclease, ExoIII, to fragment mtDNA; or mt-tat-EndoIII [0.25– 0.5 ug/g/day]: TAT sequence + mt-localization sequence + DNA repair enzyme Endo III to repair mtDNA) iv for 24 hrs prior to study. Controls were treated with vehicle. Endothelial dependent (acetylcholine, ACH), and independent (sodium nitroprusside, SNP) vasodilation was determined in isolated, cannulated mesenteric small arteries (mean diameter = 210 um). Dose-response (D-R) curves to SNP were similar in all groups and treatments suggesting that smooth muscle function was unaffected by the treatments or the pdMS. In LN controls, ACH produced dose-dependent dilation (maximal response = 99 ± 1% dilation). In LN, mtDNA fragmentation by mt-tat-ExoIII right-shifted the entire ACH D-R curve and depressed the maximal response (90 ± 2% dilation, P < 0.05 vs LN control). In OB controls, dilation to ACH was less than LN (maximal response = 82 ± 2% dilation, P < 0.05), but vasodilation in OB was completely restored to LN control levels by mtDNA repair with mt-tat-EndoIII (100 ± 1% dilation, P < 0.05 vs OB control, P = NS vs LN). We conclude that mtOxStress, and its effects on mtDNA integrity, play key roles in endothelial dysfunction in the prediabetic metabolic syndrome.
Abstract 20557: Therapeutic Hypothermia at 33C is Superior to 35C After Ischemia
Authors: Padmesh Rajput, Jilin Bai, Jessic Lamb, Patrick Lyden
Journal: Circulation (2014)

Introduction: Therapeutic hypothermia is the most potent neuroprotectant ever studied in animal models of focal or global cerebral ischemia. Although various studies have shown a protective effect of hypothermia between 30°C and 36° C, a strong debate remains regarding the efficacy of hypothermia in stroke or cardiac arrest patients, especially the ideal depth: 33°C or 36°C. Hypothesis: The present study aimed to compare directly 33°C vs. 35°C hypothermia using various durations and treatment delay times. Methods: We studied primary cultured neurons and astrocytes in an oxygen glucose deprivation (OGD) model of ischemia and hypoxia. Neurons and astrocytes were cultured from E19 and after 7 days exposed to OGD (neurons: 2h duration, astrocytes: 10h). Then, hypothermia at 33°C or 36°C began 0, 30, 60 or 90min after the OGD and lasted for 2, 4 or 24 hours. After 24h, cell viability was measured using 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT). Results: Cell viability was significantly...
Indian doctors call for protection against patients' complaints
Authors: Ganapati Mudur
Journal: BMJ (1998)

The Indian Medical Association has asked the government to amend India's consumer protection act to protect doctors from what it says are baseless and frivolous allegations of medical negligence. In a special meeting with government officials last week, the association said that the act at present is open to abuse and is damaging the relationship between doctors and patients.

The act allows people to claim compensation for deficient services in consumer courts, which are intended to work much faster than India's civil …
The Kidney: Physiology and Pathophysiology
Authors: Donald W. Seldin, Gerhard H. Giebisch
Journal: Annals of Internal Medicine (1992)

Volume 1 A history of renal physiology in 1950, Carl W. Gottschalk: general principles of electrolyte regulation - organization and control of body fluid compartments, molecular biology of transport organization of the kidney - structural organization, functional organization. Volume 2 Organization of the kidney - renal regulation of extrarenal function water and electrolyte exchanges - renal regulation of water balance - normal, renal regulation of water balance - deranged, renal regulation of sodium and chloride - normal, renal regulation of sodium and chloride - deranged, renal regulation of potassium - normal, renal regulation of potassium - deranged, renal regulation of magnesium - normal, renal regulation of magnesium - deranged, renal regulation of calcium - normal, renal regulation of calcium - deranged, renal regulation of phosphate - normal, renal regulation of phosphate - deranged, renal regulation of acid-base balance - normal, renal regulation of acid-base balance - deranged. Volume 3: Water and electrolyte exchanges - renal regulation of organic solutes and trace metals - normal, renal regulation of organic solutes and trace metals - deranged, renal regulation of proteins and macromolecules - normal, renal regulation of proteins and macromolecules - normal, renal regulation of proteins and macromolecules - deranged, extrinsic and intrinsic renal failure - failure of renal function, renal pharmacology.
Helper_dependent adenovirus with gene switch regulation may provide an optimal vector of therapeutic gene delivery for treatment of Parkinson's disease
Authors: Q. Chen, Y. He, X. Q. Yuan, P. Ng, P. Yotnda, Y. Long, E. C. Lai, K. Yang
Journal: Molecular Therapy (2004)

Gene therapy is considered one of the most promising approaches to developing a novel effective treatment for Pakinson[rsquo]s disease (PD). However, the potential unwanted side effect from viral vector or from the over expression of the transgenes are the major concerns for the future clinical applications. Thus, investigating the optimal vector for gene delivery with a controllable transgene expression mechanism is important. We had reported that helper-dependent adenovirus (hdAd), a novel adenoviral construct with full deletion of viral coding sequences, is an optimal vector to deliver the gene in the lateral ventricle with less immunogenecity and toxicity while offering extended transgene expression (Hum Gene Ther 2001;12). In present study, we injected this vector into the rat striatum to examine the transgene expression profile and the inflammatory response. We also have investigated whether mifepristone-mediated gene switch can be applied in regulating the transgene expression. HdAdv/LacZ vectors were constructed and amplified with the Cre/loxP system as described previously (Mol Ther 2000; 2). Three concentrations of hdAdv/LacZ (1X107, 1X108, and 1X109 particles/ul) were administrated into striatum of rats. After 3days, 7 days, 30days, 60days and 90days post-injection, hdAdv/LacZ expression was quantified by X-gal staining. For the gene switch studies, we have tested the mifepristone-regulated transgene expression in the CNS cell cultures and in animal model study. Different doses of mifepristone were administrated and the transgene expression levels were measured by transgene expression assays. Our results demonstrate that intrastriatal inoculation of hdAdv vector produced a potent transgene expression with minimal inflammatory responses. The hdAdv/lacZ can retrograde transport to the substantia nigra 3-day after intrastriatal injection and last for a long period. The potency of the transgene expression is dose dependent. In in vitro studies, we have found that mifepristone induced a 28-fold higher level of transgene expression in cultures transducted with the gene switch vector, compared with non-mifepristone-treated cultures. The transgene expression levels are mifepristone dose dependent. The results are also confirmed in in vivo study. The preliminary results suggest that mifepristone-induced gene switch system could efficiently induce transgene expression. HdAdv with gene switch system may provide an optimal vector for therapeutic gene delivery for treatment of PD. The next step is to study the therapeutic effects of intrastriatal delivery of hdAdv/GDNF with mifepristone induced gene switch element in PD animal models.
The gene encoding ribosomal protein S19 is mutated in Diamond-Blackfan anaemia
Authors: Natalia Draptchinskaia, Peter Gustavsson, Björn Andersson, Monica Pettersson, Thiébaut-Noël Willig, Irma Dianzani, Sarah Ball, Gil Tchernia, Joakim Klar, Hans Matsson, Dimitri Tentler, Narla Mohandas, Birgit Carlsson, Niklas Dahl
Journal: Nature Genetics (1999)
Abstract 4457: Regulation of GRM1 by estrogen receptor in breast cancer
Authors: Sonia C. Dolfi, Madhura S. Mehta, David Kornblum, Andrew Boughton, Hussein Rahim, Daniel Medina, Kim M. Hirshfield
Journal: Cancer Research (2014)

Abstract Metabotropic glutamate receptor 1 (GRM1), first recognized as an important factor in the central nervous system, has more recently been implicated in melanomagenesis and breast cancer pathogenesis. Oncogenic mediators of GRM1-associated effects include both MAPK and AKT signaling cascades. Modulation of GRM1 activity in melanoma and estrogen receptor negative (ER-) breast cancer cells inhibits anchorage independent growth, migration, proliferation, and/or downstream activation of Akt and ERK. Data from our laboratory show that a significantly higher fraction of breast tumors express GRM1 compared to normal breast tissue, and GRM1 expression is more highly correlated with ER positivity. Moreover, higher GRM1 expression in human ER+ breast cancers treated with the anti-estrogen tamoxifen associates with a shorter distant metastasis free survival as compared to low expressors further supporting a critical role in ER+ breast cancer. We hypothesize that ER has both genomic and non-genomic effects on GRM1. We evaluated the effect of hormonal treatment on GRM1 protein expression in ER+ MCF7 and ER- MDA-MB-231 breast cancer cells. Estradiol increases GRM1 expression, and this effect is abrogated by the anti-estrogen tamoxifen in MCF7 but not in MDA-MB-231 cells. These genomic effects may be exerted through three putative ER binding sites within the GRM1 promoter. We have confirmed that ER binds to one of these sites by chromatin immunoprecipitation, further supported by ChiPSeq data. GRM1 promoter activity is increased by estradiol treatment using a luciferase reporter assay validating transcriptional activation by ER. To support a non-genomic role for ER with GRM1, we have shown that ER physically interacts with GRM1 in breast cancer cells by in vitro proximity ligation assay and by co-immunoprecipitation in immortalized mouse mammary epithelial cells (iMMECs) stably expressing GRM1. Stable introduction of GRM1 into iMMECs, which lack endogenous GRM1, reduces sensitivity to tamoxifen as compared to control iMMECs. In MCF7 cells, the combination of tamoxifen with GRM1 modulators riluzole or BAY 36-7620 produces synergistic effects. As estradiol activates MAPK signaling in breast cancer cells, we hypothesize that this may be mediated by both the physical interaction of GRM1 and ER and the indirect effects on GRM1 transcription. Results of these studies suggest that GRM1 may be a valuable therapeutic target in ER+ breast tumors. Citation Format: Sonia C. Dolfi, Madhura S. Mehta, David Kornblum, Andrew Boughton, Hussein Rahim, Daniel Medina, Kim M. Hirshfield. Regulation of GRM1 by estrogen receptor in breast cancer. [abstract]. In: Proceedings of the 105th Annual Meeting of the American Association for Cancer Research; 2014 Apr 5-9; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2014;74(19 Suppl):Abstract nr 4457. doi:10.1158/1538-7445.AM2014-4457
A CASE OF EPIDEMIC HEMORRHAGIC FEVER IN THE UNITED STATES
Authors: B Z HIBBARD, V B BALLARD, D M GIBSON
Journal: Annals of Internal Medicine (1954)

Case Reports1 May 1954A CASE OF EPIDEMIC HEMORRHAGIC FEVER IN THE UNITED STATESBLAINE Z. HIBBARD, M.D., V. BRYCE BALLARD, M.D., DAVID M. GIBSON, M.D.BLAINE Z. HIBBARD, M.D.Search for more papers by this author, V. BRYCE BALLARD, M.D.Search for more papers by this author, DAVID M. GIBSON, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-40-5-1005 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptEpidemic hemorrhagic fever presents a difficult diagnostic problem to physicians in the United States because of the bizarre leukemoid blood picture, the thrombocytopenia with petechiae followed by a rather typical lower nephron nephrosis syndrome. We present herewith a case which occurred in a civilian who was discharged from the Armed Forces November 21, 1953 at Camp Carson, Colorado, and who arrived in Kansas City, Missouri on November 22. He developed prodromal symptoms which consisted of fleeting dizzy sensations and fatigue on November 26 and 27 and became acutely ill on the evening of November 29.CASE REPORTJ. F. H.,...Bibliography1. Smadel JE: Epidemic hemorrhagic fever, Am. J. Pub. Health 43: 10, 1953. Google Scholar2. PruittCleve FWEA: Epidemic hemorrhagic fever, Am. J. M. Sc. 225: 6, 660, 1953. CrossrefGoogle Scholar3. Andrew R: Epidemic hemorrhagic fever, Brit. M. J. 4819 (May 16) 1953. Google Scholar4. Powell GM: Clinical manifestations of epidemic hemorrhagic fever, J. A. M. A. 151: 1261, 1953. MedlineGoogle Scholar5. Barbero GJ: Clinical and laboratory study of thirty-one patients with hemorrhagic fever, A. M. A. Arch. Int. Med. 91: 177, 1953. CrossrefGoogle Scholar6. McNinch JH: A symposium on epidemic hemorrhagic fever, Ann. Int. Med. 38: 53, 1953. LinkGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Kansas City, Missouri*Received for publication January 18, 1954. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byTwenty-Year Summary of Surveillance for Human Hantavirus Infections, United StatesArbor-Viren (durch Arthropoden übertragbare Viren)Das epidemische h�morrhagische FieberHemorrhagic fever 1 May 1954Volume 40, Issue 5Page: 1005-1010KeywordsArmed forcesBloodCyclic adenosine monophosphateFatigueHemorrhagic feversLeukemoidNephronsResearch laboratories Issue Published: 1 May 1954 PDF downloadLoading ...
Abstract 13238: Simvastatin Upregulates Endothelial Cell Integrin β4 Expression by Promoter Activation and Epigenetic Modification
Authors: Weiguo Chen, Xiuqin Ni, Lishi Xie, Venkateswan Elagovan, Jeffrey R Jacobson
Journal: Circulation (2014)

Introduction: We previously reported that protection conferred by simvastatin in murine acute lung injury (ALI) is mediated by the upregulation of endothelial cell integrin β4 (ITGB4). However, the mechanisms underlying these effects are unknown. To explore this further, we investigated ITGB4 promoter regulation and epigenetic modifcations by simvastatin. Methods: Human pulmonary artery EC were transfected with luciferase reporter promoter deletion constructs prior to treatment with simvastatin (5 μM) to identify specific 5’ regions within the ITGB4 gene responsible for statin-mediated ITGB4 expression. Regions of interest were then subjected to chromatin immuoprecipitation (ChIP) to identify candidate transcription factors (TFs). In separate experiments, ECs were pretreated with either a histone deacteylation inhibitor, trichostain (TSA, 5 μM, 2h), or a histone methylation inhibitor, 5-aza-2’-deoxycytidine (5-Aza, 5 μM, 2h) prior to treatment with simvastatin (5 μM, 16 h) followed by ITGB4 mRNA and prote...
TextBook of Electrocardiography.
Authors: Hilliard J. Katz
Journal: Annals of Internal Medicine (1972)

more feasible.Repeat perfusions have been necessary in most patients over a period of at least three months, and sepsis has been a major problem.In the final section new techniques of skin replacement using th-synthetic membrane polytetrafluoroethylene are discussed and appear to offer promise in the severely burned patient.Current progress in organ preservation, banking, and freezing are also presented.This highly informative, well-written symposium is the best review of the field of artificial organs and support systems currently available.
An Ethical Debate: Elective ventilation of potential organ donors
Authors: H. Riad, A. Nicholls
Journal: BMJ (1995)

Elective ventilation describes the procedure of transferring selected patients dying from rapidly progressive intracranial haemorrhage from general medical wards to intensive care units for a brief period of ventilation before confirmation of brain stem death and harvesting of organs. This approach in Exeter has led to a rate of kidney retrieval and transplant higher than has been achieved elsewhere in the United Kingdom, with a stabilisation of numbers on patients on dialysis. Recently doubt has been cast on the legality of our practice of elective ventilation on the grounds that relatives are not permitted to consent to treatment of an incompetent person when that treatment is not in the patient's best interests. We are thus faced with the dilemma of a protocol that is ethical, practical, and operates for the greater good but which may be illegal. This article explores various objections to the protocol and calls for public, medical, and legal debate on the issues.
The Duffy-binding-like domain 1 of Plasmodium falciparumerythrocyte membrane protein 1 (PfEMP1) is a heparan sulfate ligand that requires 12 mers for binding
Authors: Antonio Barragan, Victor Fernandez, Qijun Chen, Anne von Euler, Mats Wahlgren, Dorothe Spillmann
Journal: Blood (2000)
Medicine in a Disaster Area
Authors: Ofer Merin, Avraham Yitzhak, Tarif Bader
Journal: JAMA Internal Medicine (2015)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Internal Medicine HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Internal Medicine journal