tbuckley/cabot-search huggingface dataset:
Ultracentrifugal isolation of vesicular carriers of biliary cholesterol in native human and rat bile
Authors: Natalia Ulloa, Jorge Garrido, Flavio Nervi
Journal: Hepatology (1987)

We have utilized ultracentrifugation of native bile-Metrizamide density gradients to isolate a vesicular transport system or biliary lipids in both man and rat. We identified vesicular structures by electron microscopy. Fresh bile specimens were obtained from bile fistula rats (unsaturated bile) and from patients 1 week after bile duct surgery (supersaturated bile). Metrizamide was dissolved in bile (33% w/v), and continuous density gradients were performed with undiluted bile (density limits = 1.020 to 1.300 gm per ml). The relative distribution of biliary cholesterol, phospholipid and bile salt was studied as a function of the density of the fractions. Approximately 50% of total rat biliary cholesterol and between 61 and 90% of human biliary cholesterol was concentrated in the lightest fractions of the gradients (density < 1.060 gm per ml). In contrast, less than 20% of bile salts was present in fractions with densities lower than 1.060 gm per ml. The highest amounts of bile salts and phospholipids of the bile-Metrizamide density gradients were found in the density range of 1.075 to 1.100 gm per ml in both human and rat bile. More than 80% of biliary proteins was found in fractions with densities < 1.075 gm per ml, and only 2% was found in the cholesterol-rich fraction with density < 1.060 gm per ml in both species. When bile salt concentration was raised in rat bile from 38 to 97 mM by adding taurocholate, the low density cholesterol-rich fraction almost disappeared. Electron microscopy of negatively stained preparations of the fractions with density < 1.060 gm per ml showed 40 to 120 nm vesicles, which were not apparent in the other fractions. Similar vesicles were demonstrated also in fresh rat bile and within the canaliculi after acute depletion of the bile salt pool (biliary bile salt concentration of 3.45 mM; total biliary lipid concentration of 0.25 gm%). The structure of these vesicles was shown in thin sections of liver specimens. They appeared as internal cavities surrounded by a single, continuous 6-nm-thick bilayer. These studies demonstrate that a high proportion of biliary cholesterol is transported in vesicles in human supersaturated native bile and that vesicular carriers are also responsible for the transport of a significant amount of biliary cholesterol in unsaturated rat bile. The presence of vesicles in unsaturated hepatic bile strongly supports the thesis that biliary lipids may be secreted as vesicles from the hepatocyte into the canaliculi.
Milieu and Mental Health in a Norwegian Fishing Community
Authors: Per Fugelli
Journal: Psychotherapy and Psychosomatics (1979)

During 1970-1973 a comprehensive epidemiological investigation was carried out on the island of Vaerøy and Røst in Northern Norway; 1,700 people live in the area and fishing provides the main employment. The paper contains mainly a morbidity study, with special reference to factors in the local milieu influencing the morbidity pattern. A few of the major results concerning living conditions and mental health in this fishing population are presented.
Scientific and Legal Perspectives on Science Generated for Regulatory Activities
Authors: Carol J. Henry, James W. Conrad
Journal: Environmental Health Perspectives (2007)

This article originated from a conference that asked “Should scientific work conducted for purposes of advocacy before regulatory agencies or courts be judged by the same standards as science conducted for other purposes?” In the article, which focuses on the regulatory advocacy context, we argue that it can be and should be. First, we describe a set of standards and practices currently being used to judge the quality of scientific research and testing and explain how these standards and practices assist in judging the quality of research and testing regardless of why the work was conducted. These standards and practices include the federal Information Quality Act, federal Good Laboratory Practice standards, peer review, disclosure of funding sources, and transparency in research policies. The more that scientific information meets these standards and practices, the more likely it is to be of high quality, reliable, reproducible, and credible. We then explore legal issues that may be implicated in any effort to create special rules for science conducted specifically for a regulatory proceeding. Federal administrative law does not provide a basis for treating information in a given proceeding differently depending on its source or the reason for which it was generated. To the contrary, this law positively assures that interested persons have the right to offer their technical expertise toward the solution of regulatory problems. Any proposal to subject scientific information generated for the purpose of a regulatory proceeding to more demanding standards than other scientific information considered in that proceeding would clash with this law and would face significant administrative complexities. In a closely related example, the U.S. Environmental Protection Agency considered but abandoned a program to implement standards aimed at “external” information.
Impact of pretransplant hyponatremia on outcome following liver transplantation
Authors: Byung Cheol Yun, Ray W. Kim, Joanne T. Benson, Scott W. Biggins, Terry M. Therneau, Walter K. Kremers, Charles B. Rosen, Goran B. Klintmalm
Journal: Hepatology (2009)

Hyponatremia is associated with reduced survival in patients with cirrhosis awaiting orthotopic liver transplantation (OLT). However, data are sparse regarding the impact of hyponatremia on outcome following OLT. We investigated the effect of hyponatremia at the time of OLT on mortality and morbidity following the procedure. The study included 2,175 primary OLT recipients between 1990 and 2000. Serum sodium concentrations obtained immediately prior to OLT were correlated with subsequent survival using proportional hazards analysis. Morbidity associated with hyponatremia was assessed, including length of hospitalization, length of intensive care unit (ICU) admission, and occurrence of central pontine myelinolysis (CPM). Out of 2,175 subjects, 1,495 (68.7%) had normal serum sodium (>135 mEq/L) at OLT, whereas mild hyponatremia (125-134 mEq/L) was present in 615 (28.3%) and severe hyponatremia (<125 mEq/L) in 65 (3.0%). Serum sodium had no impact on survival up to 90 days after OLT (multivariate hazard ratio = 1.00, P = 0.99). Patients with severe hyponatremia tended to have a longer stay in the ICU (median = 4.5 days) and hospital (17.0 days) compared to normonatremic recipients (median ICU stay = 3.0 days, hospital stay = 14.0 days; P = 0.02 and 0.08, respectively). There were 10 subjects that developed CPM, with an overall incidence of 0.5%. Although infrequent, the incidence of CPM did correlate with serum sodium levels (P < 0.01).Pre-OLT serum sodium does not have a statistically significant impact on survival following OLT. The incidence of CPM correlates with hyponatremia, although its overall incidence is low. Incorporation of serum sodium in organ allocation may not adversely affect the overall post-OLT outcome.
Early and Long-Term Results of a Valve-Sparing Operation for Marfan Syndrome
Authors: E. J. Birks, C. Webb, A. Child, R. Radley-Smith, M. H. Yacoub
Journal: Circulation (1999)

We have previously described the experience, rationale, and development of a valve preserving technique, but its role in patients with Marfan syndrome has not previously been defined. Here, we attempt to determine the early and long-term results, timing, and determinants of outcome of this operation in patients with Marfan syndrome.Since 1979, 82 patients (73.2% of all patients with Marfan syndrome undergoing resection of aneurysm of the ascending aorta) were operated on using this technique. Ages ranged from 2 to 69 years (mean, 33.9 years). In all, there were 4 early deaths (4.9%), 2 with acute dissection and 2 with chronic aneurysm operated on as emergencies. There were no early deaths in 67 patients operated on electively. Actuarial survival for patients operated for chronic aneurysm was 94.2%, 94.2%, and 94.2% at 1, 5, and 10 years, respectively; that for acute dissection was 72.7%, 63. 6%, and 63.6%; and that for chronic dissection was 100%, 85.7%, and 75.0%. The probability of needing reoperation was 5.7%, 17.3%, and 17.3% at 1, 5, and 10 years. There were no instances of infective endocarditis or thromboembolic complications except in 2 patients operated on early in the series who had cusp extension. At the end of the follow-up, trivial or no aortic regurgitation was demonstrated in 33.3%, mild in 45.6%, moderate in 21.1%, and severe in 0.Valve-sparing operations are feasible in most patients with Marfan syndrome; they are applicable to patients with both dissection and chronic aneurysm. The early and long-term results are encouraging. Results are better in the absence of dissection, and prophylactic operation is warranted in some cases.
Is t(14;18)(q32;q21) a constant finding in follicular lymphoma? An interphase FISH study on 63 patients
Authors: A Godon, A Moreau, P Talmant, L Baranger-Papot, F Geneviève, N Milpied, M Zandecki, H Avet-Loiseau
Journal: Leukemia (2003)
Relationship between transcardiac extraction of aldosterone and left ventricular remodeling in patients with first acute myocardial infarction: extracting aldosterone through the heart promotes ventricular remodeling after acute myocardial infarction
Authors: Masaru Hayashi, Takayoshi Tsutamoto, Atsuyuki Wada, Keiko Maeda, Naoko Mabuchi, Takashi Tsutsui, Toshiki Matsui, Masanori Fujii, Takehiro Matsumoto, Takashi Yamamoto, Hajime Horie, Masato Ohnishi, Masahiko Kinoshita
Journal: Journal of the American College of Cardiology (2001)
A pivotal role for galectin-1 in fetomaternal tolerance
Authors: Sandra M Blois, Juan M Ilarregui, Mareike Tometten, Mariana Garcia, Arif S Orsal, Rosalia Cordo-Russo, Marta A Toscano, Germán A Bianco, Peter Kobelt, Bori Handjiski, Irene Tirado, Udo R Markert, Burghard F Klapp, Francoise Poirier, Julia Szekeres-Bartho, Gabriel A Rabinovich, Petra C Arck
Journal: Nature Medicine (2007)
Stepwise circumferential and focal ablation of Barrett’s esophagus with high-grade dysplasia: results of the first prospective series of 11 patients
Authors: J. Gondrie, R. Pouw, C. Sondermeijer, F. Peters, W. Curvers, W. Rosmolen, K. Krishnadath, F. Ten Kate, P. Fockens, J. Bergman
Journal: Endoscopy (2008)

See also: Commentaire de "Traitement de l'œsophage de Barrett par radiofréquence" (4 articles), pp. 359Endoscopy 2008; 40(05): 453-454DOI: 10.1055/s-0032-1306830
Endoscopic Treatment of a Large Upper Gastrointestinal Anastomotic Leak Using a Prolene Plug and Cyanoacrylate
Authors: S. Disibeyaz, E. Parlak, A. S. Koksal, B. Cicek, U. Koc, B. Sahin
Journal: Endoscopy (2005)

Anastomotic leaks occur in up to 20 % of patients after upper gastrointestinal surgery, and they represent a significant source of postoperative morbidity and mortality. The treatment options include surgery, conservative treatment, or endoscopic treatment. In this report, we present the case of a patient who was successfully treated with a combination of a Prolene (polypropylene) plug and cyanoacrylate.
DISLOCATION OF THE SEMILUNAR CARPAL BONE
Authors: HARRY B. KNAPP
Journal: JAMA (1922)

Dislocation of the semilunar carpal bone is not likely to occur often enough to be of much moment to physicians generally, but the fact that it may occur in almost any severe wrist injury makes recognition of this lesion imperative. The American literature in the last few years contains comparatively few reports of cases of semilunar carpal bone dislocation. The European literature, especially the German, is replete with references to semilunar carpal bone dislocations, but no great number of cases have been studied. I am unwilling to believe, however, that this lesion is as infrequent as these reports would seem to indicate. That this particular injury does occur more often than formerly may be due to the great number of accidents caused by the backfire of gas engines, which is a common factor in producing wrist injuries. The present universal use of the roentgen ray in the diagnosis of wrist
Is syndrome X a ischemic heart disease? Evaluation by continuous ventricular function monitoring (VEST) and 18fluorodeoxyglucose positron emission CT (PET)
Authors: Tatsuhiko Hata, Ryuji Nohara, Ryohei Hosokawa, Masatoshi Fujita, Takashi Kudo, Nagara Tamaki, Junji Konishi, Shigetake Sasayama
Journal: Journal of the American College of Cardiology (1996)
MANGANESE AS A CHEMO-THERAPEUTIC AGENT.*
Authors: J. E. R. McDONAGH
Journal: British Journal of Dermatology (1923)

Journal Article MANGANESE AS A CHEMO‐THERAPEUTIC AGENT. Get access J. E. R. McDONAGH, F.R.C.S. J. E. R. McDONAGH, F.R.C.S. Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology and Syphilis, Volume 35, Issue 3, 1 March 1923, Pages 98–106, https://doi.org/10.1111/j.1365-2133.1923.tb09091.x Published: 01 March 1923
Researchers Draft Guidelines for Clinical Use of Pharmacogenomics
Authors: Tracy Hampton
Journal: JAMA (2006)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Correction: Additional Author
Authors: FREDERICK M. VINCENT
Journal: Annals of Internal Medicine (1978)

Letters and Corrections1 March 1978Correction: Additional AuthorFREDERICK M. VINCENT, M.D.FREDERICK M. VINCENT, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-88-3-434_6 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: In my paper "Abdominal Pain and Slipping-Rib Syndrome" in the January issue (Ann Intern Med88:129-130, 1978), I inadvertently omitted the other author's name. My co-author was Stephen S. Kennedy, M.D.... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: FREDERICK M. VINCENT, M.D.Affiliations: Dartmouth Medical School Hanover, NH 03755 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 March 1978Volume 88, Issue 3Page: 434-434KeywordsAbdominal pain ePublished: 1 December 2008 Issue Published: 1 March 1978 PDF downloadLoading ...
Characterization of fusion partner genes in 114 patients with de novo acute myeloid leukemia and MLL rearrangement
Authors: L-y Shih, D-c Liang, J-f Fu, J-h Wu, P-n Wang, T-l Lin, P Dunn, M-c Kuo, T-c Tang, T-h Lin, C-l Lai
Journal: Leukemia (2005)
THE TREATMENT OF INSOMNIA.
Authors: ROBERT T. EDES
Journal: JAMA (1898)

Insomnia is, of course, only a symptom but, like many other symptoms, it occasionally stands alone as representing some functional disturbance of which we have no other means of information. When we speak of the treatment of insomnia as such, we ought not to include the treatment of the pains or discomforts from various known sources which may keep the patient awake, or of many forms of insanity, of delirium tremens or other kinds of poisoning. This narrows our limits very much, but at the same time makes the problem more precise. The practitioner or writer, however, does not get rid of its difficulties by these exclusions, for many of the cases which present no other important symptoms, so that the patient has nothing to tell as to his bodily condition except that he can not sleep, are more difficult to manage successfully than one where we can put a
Molecular mechanism for the involvement of nuclear receptor FXR in HBV-associated hepatocellular carcinoma
Authors: Yong-dong Niu, Wen Xie, Wen-xin Qin
Journal: Acta Pharmaceutica Sinica B (2011)

Farnesoid X receptor (FXR, also termed nuclear receptor NR1H4) is critically involved in the regulation of nascent bile formation and bile acid enterohepatic circulation. FXR and bile acids have been shown to play roles in liver regeneration and inflammatory responses. There is increasing evidence suggesting that FXR and the FXR signaling pathway are involved in the pathophysiology of a wide range of liver diseases, such as viral hepatitis, cirrhosis, and hepatocellular carcinoma (HCC). Here we discuss the latest discoveries of FXR functions with relevance to bile acid metabolism and HBV-associated HCC. More specifically, the goal of this review is to discuss the roles of FXR and bile acids in regulating HBV replication and how disregulation of the FXR-bile acid signaling pathway is involved in HBV-associated hepatocarcinogenesis.
Endovascular Stent Design Dictates Experimental Restenosis and Thrombosis
Authors: Campbell Rogers, Elazer R. Edelman
Journal: Circulation (1995)

Background Vascular interventions that maximize initial lumen diameter provoke extensive neointimal hyperplasia but minimize its effects, causing long-term lumen size to be greater. Nevertheless, interventions such as endovascular stents, which increase lumen size above that achieved with balloon angioplasty, are subject to frequent thrombosis and restenosis. It has been unclear whether the response to stent-induced injury is determined solely by the degree of stent-induced arterial expansion or whether the geometric configuration of the stent or the material left in contact with the vessel wall also contribute. Methods and Results We examined the vascular response to steel stents deployed in denuded rabbit iliac arteries for 14 days. In one set of experiments, the effects of stent configuration were examined, holding diameter, mass, surface area, and stent surface material constant. In another set, stent surface material was changed, with mass, configuration, and diameter unaltered. Changing stent configuration to reduce strut-strut intersections by 29% without affecting mass or surface area reduced vascular injury by 42%, thrombosis by 69%, and neointimal hyperplasia by 38%. Monocyte adhesion to stented arteries correlated linearly with vascular trauma and neointimal hyperplasia ( r =.96, P &lt;.01 for each). When the stainless steel surface was coated with an inert polymer material, vascular injury and neointimal hyperplasia were unchanged, but thrombosis was eliminated. Conclusions Surface material and geometric configuration of stents may be more important than postplacement diameter in determining neointimal hyperplasia and thrombosis. Alterations in configuration affect vascular injury and neointimal hyperplasia, while surface material plays a greater role in thrombosis. Monocytes may be important modulators of stent-induced intimal thickening. Clinical confirmation of these findings may alter coronary stent deployment techniques and future stent designs.
THE TREATMENT OF HEMOPHILIA
Authors: HAROLD W. JONES
Journal: JAMA (1934)

It is 130 years since hemophilia was first observed and accurately described by Otto.<sup>1</sup>The progress in its therapy has been slow and full of disappointments. This report will deal with a review of the methods of treatment of the condition at the disposal of the physician today. It is based partially on observations made on twelve hemophilic patients at various times over a period of seven years. For the purpose of this discussion, hemophilia is defined as an inherited or noninherited tendency of males to bleed, characterized by the presence of a prolongation of the coagulation and prothrombin time of the venous blood. Cases of hemophilia in which a history of inheritance is not obtainable are included. Five of our patients fall in this group, although four of them have brothers similarly affected. Instances of so-called sporadic hemophilia are about as frequent as those in which a clear-cut
Doppler-derived mitral deceleration time of early filling as a strong predictor of pulmonary capillary wedge pressure in postinfarction patients with left ventricular systolic dysfunction
Authors: Pantaleo Giannuzzi, Alessandro Imparato, Pier L. Temporelli, Francesco de Vito, Pedro L. Silva, Francesco Scapellato, Amerigo Giordano
Journal: Journal of the American College of Cardiology (1994)
ANTIBODY FORMATION
Authors: Jonathan W. Uhr, Joyce B. Baumann
Journal: The Journal of Experimental Medicine (1961)

Diphtheria toxoid-antitoxin precipitates formed in antitoxin excess can prepare guinea pigs, rats, and rabbits for a secondary type of antitoxin response. Priming may occur without the development of detectable serum antibody. In rats, toxoid-antitoxin precipitates are more efficient than "free" toxoid in priming, whereas in guinea pigs, the magnitude of the anamnestic response varies with the precipitate employed. The possibility that priming is due to "free" antigen released from the specific precipitate rather than the precipitate itself is discussed. The anamnestic antitoxin response can be inhibited by passive antitoxin, but less efficiently than primary antitoxin formation. Partial suppression of the secondary antitoxin response was accomplished by injection of excess horse antitoxin as long as 4 days after reimmunization with toxoid. The importance of these findings for the understanding of passive-active immunization in the human is discussed.
857 NEUROPHYSIOLOGY OF FATIGUE IN PRIMARY BILIARY CIRRHOSIS SUGGESTS A CENTRAL ORIGIN AND A MOTIVATIONAL IMPAIRMENT
Authors: C.A. Cocchi, G. Cerri, M. Montagna, M. Zuin, P. Invernizzi, M. Podda, P. Cavallari, C. Selmi
Journal: Journal of Hepatology (2008)