ROENTGEN THERAPY OF CUSHING'S SYNDROME (PITUITARY BASOPHILISM): REPORT OF A CASE OBSERVED FOR ELEVEN YEARS
Authors: Ernst A. Pohle, Irving Weissman
Journal: Annals of Internal Medicine (1950)

Case Reports1 March 1950ROENTGEN THERAPY OF CUSHING'S SYNDROME (PITUITARY BASOPHILISM): REPORT OF A CASE OBSERVED FOR ELEVEN YEARSERNST A. POHLE, M.D., Ph.D., IRVING WEISSMAN, M.D.ERNST A. POHLE, M.D., Ph.D.Search for more papers by this author, IRVING WEISSMAN, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-32-3-542 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptSince Cushing's4original description in 1932 the syndrome of pituitary basophilism has become a well recognized entity. It is an uncommon disease which occurs more frequently in females than in males. The manifestations of the syndrome are painful obesity limited chiefly to the face, neck, shoulders and abdomen, thin reddish skin with purplish striae, acrocyanosis, hypertension and arteriosclerosis, kyphosis and backache with osteoporosis frequently resulting in multiple compression fractures of the vertebrae, weakness, amenorrhea in women, impotence in men, hirsutism without other evidence of virilism and hypoglycemia. The significant laboratory findings according to Albright1are an unresponsive alimentary hyperglycemia, insulin...Bibliography1. Albright F: Cushing's syndrome, Harvey Lecture 38: 125-186, 1942-1943. Google Scholar2. CantrilBuschke STF: Roentgen therapy of adenomas; radiation therapy conference, West. J. Surg. 54: 403-407, 1946. Google Scholar3. CrookeCallow ACRK: The differential diagnosis of forms of basophilism (Cushing's syndrome), particularly by the estimation of urinary androgens, Quart. J. Med. n. s. 8: 233-249, 1939. Google Scholar4. Cushing H: Basophilic adenomas of the pituitary, Bull. Johns Hopkins Hosp. 50: 137-195, 1942. Google Scholar5. DavidoffFeiring LMEH: Surgical treatment of tumors of the pituitary body, Am. J. Surg. 75: 99-136, 1948. CrossrefMedlineGoogle Scholar6. DykeDavidoff CGLM: Roentgen treatment of diseases of the nervous system, 1942, Lea & Febiger, Philadelphia. Google Scholar7. EllmanVilvandre PG: Basophilism treated successfully by deep x-ray therapy, Proc. Roy. Soc. Med. 39: 516, 1946. CrossrefGoogle Scholar8. Gordon ES: Personal communication. Google Scholar9. Grant FC: Surgical treatment of pituitary adenomas, J. A. M. A. 113: 1279-1282, 1939. CrossrefGoogle Scholar10. Jamin F: Die hypophysäre Plethora (Cushingsche Krankheit: pituitary basophilism), München. med. Wchnschr. 81: 1045-1049, 1085, 1934. Google Scholar11. KerrCooper HDWK: Roentgen therapy of pituitary adenomas, Am. J. Roentgenol. 48: 467-475, 1942. Google Scholar12. Kerr HD: Irradiation of pituitary tumors, presented at Atlantic City meeting of the American Roentgen Ray Society, Sept. 1947; quoted in reference 5. Google Scholar13. Lisser H: Hypophysectomy in Cushing's disease (report of a case), J. Nerv. and Ment. Dis. 99: 727-733, 1944. CrossrefGoogle Scholar14. Luft R: Irradiation treatment of Cushing's syndrome, Acta med. Scandinav. 124: 227-251, 1946. CrossrefGoogle Scholar15. PaschkesHerbutRakoffCantarow KEPAAEA: A case of Cushing's syndrome with adrenal cortical hyperplasia without pituitary basophilism, J. Clin. Endocrinol. 3: 212-217, 1943. CrossrefGoogle Scholar16. PerloffRoseSunderman WHEWF: Cushing's syndrome; therapeutic observations, Arch. Int. Med. 72: 494-505, 1943. CrossrefGoogle Scholar17. Sosman MC: Irradiation in the treatment of pituitary adenomas, Interst. Postgrad. M. A. North America, pp. 18-22; pp. 239-245, 1937. Google Scholar18. Sosman MC: Roentgen therapy of pituitary adenomas, J. A. M. A. 113: 1282-1285, 1939. CrossrefGoogle Scholar19. SussmanCopleman MLB: Roentgenographic appearances of the bones in Cushing's syndrome, Radiology 39: 288-292, 1942. CrossrefGoogle Scholar20. ThompsonEisenhardt KWL: Cushing's syndrome; further considerations, J. Clin. Endocrinol. 3: 445-452, 1943. CrossrefGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Madison, Wisconsin*Received for publication June 24, 1948.From the University of Wisconsin Medical School. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byDie Keimdrüsen und ihre KrankheitenThe natural history of cushing's syndrome 1 March 1950Volume 32, Issue 3Page: 542-548KeywordsHypertensionHypoglycemiaInsulinKyphosisLower back painObesityOsteoporosisResearch laboratoriesShouldersVertebrae ePublished: 1 December 2008 Issue Published: 1 March 1950 PDF downloadLoading ...