tbuckley/cabot-search huggingface dataset:
Abstract 16274: Identification of Novel CAD Genetic Loci by 1000 Genomes-Based Imputation and a Non-Additive Discovery Screen
Authors: Majid Nikpay, Anuj Goel, Hong-Hee Won
Journal: Circulation (2014)

Introduction: Known common coronary artery disease (CAD) risk variants explain only 10% of the predicted genetic heritability of the disease, suggesting that important genetic signals remain to be discovered. Hypothesis: The 1000 Genomes imputation training set, and non-additive discovery screens, may allow detection of additional CAD-associated genetic variants that contribute to missing heritability. Methods: As part of the CARDIoGRAMplusC4D Consortium, we assembled 48 GWAS of CAD that included 1000 Genomes imputed data. These consisted of 60,801 CAD cases and 123,504 controls, 23% being of non-European ancestry. In each study, GWAS analysis was carried out by assuming an additive, dominant or recessive model of inheritance, and followed by meta-analysis to combine the GWAS results for each model. Results: After QC filtering, 9.4 million variants (91% SNPs, 9% INDELs) were available for meta-analysis. 29% of these were lower frequency variants (0.005 &lt; MAF &lt; 0.05). Novel associations (P &lt; 5 x 10 -8 , and outside of known CAD genomic regions) under the additive model were detected for 38 variants (8% INDELs) with imputation info score of 0.94 [0.88-0.96] (median [IQR]). Of note, 34% of novel variants (N=13) were of low allele frequency (MAF &lt; 0.05; median [IQR] = 0.03 [0.02-0.03]); these exhibited much larger effect sizes (P &lt; 0.0001; Cohen’s d = 2.3) as compared to the common variants (MAF ≥ 0.05). The newly identified variants were mapped to 10 novel genomic loci for CAD. Together, these variants explained 2.5% of the heritability of CAD and majority (60%) were intronic. Three of these loci fit a dominant mode of inheritance. An additional two novel loci were identified by a recessive mode of inheritance. Among the newly identified loci, three had been previously reported at GWAS levels of significance for metabolic traits. Conclusions: These findings demonstrate the value of using a global imputation training set to enhance coverage of low allele frequency and incompletely tagged variants. Consideration of non-additive models of inheritance enabled identification of additional genetic variants associated with CAD.
Abstract MP12: Dietary Fatty Acids and Risk of Incident Atrial Fibrillation in the Women’s Health Study
Authors: Stephanie E Chiuve, Roopinder K Sandhu, M. V Moorthy, Robert J Glynn, Christine M Albert
Journal: Circulation (2014)

Background: Atrial fibrillation (AF) is the most common cardiac arrhythmia and a major risk factor for stroke, heart failure and mortality. Dietary fats may have effects on biologic pathways involved in inflammation, fibrosis, and cellular electrophysiology that influence the development and maintenance of AF. Prior studies evaluating the relationship between N-3 polyunsaturated fats and total AF events have had inconsistent results. Furthermore, few studies have reported the association between other dietary fats and incident AF or whether associations might differ by AF pattern. Methods: We followed 33,041 initially healthy women from the Women's Health Study, who were &gt;45 years and free of AF at baseline in 1993. Intake of individual fats was calculated from a food frequency questionnaire administered at baseline. Self-reported AF was confirmed by EKG and medical record review. We defined AF patterns as paroxysmal (self-terminating for &lt;7 days and no cardioversion), persistent (sustained &gt;7 days and/or required cardioversion) and chronic (cardioversion failed / not attempted). Patterns were classified according to the most severe pattern within 2 years of AF onset and we combined persistent and chronic AF for analysis. We used isocaloric multivariable Cox proportional hazards models, adjusting for diet, lifestyle and clinical CVD risk factors, with a competing risk framework to evaluate whether dietary fats share equal associations across various AF patterns. Results: We documented 1286 cases of AF (821 paroxysmal &amp; 423 persistent/chronic) over a median follow-up of 17.4 years. There was no significant association between any dietary fat and risk of incident AF. Saturated fat was associated with higher risk, and monounsaturated fat with lower risk of persistent/chronic AF. The RR (95%CI) for a substitution of 5% of energy from saturated fat for an equal percentage of energy from carbohydrates was 1.47 (1.02, 2.12) for persistent/chronic AF and 0.84 (0.64, 1.10) for paroxysmal AF (p, diff = 0.01). For monounsaturated fat, the RR for a 5% increment was 0.67 (0.45, 0.98) for persistent/chronic AF and 0.86 (0.73, 1.27) for paroxysmal AF, although the difference between patterns did not reach significance (p, diff = 0.12). Intake of N-3 and n-6 polyunsaturated fat and trans fat were not differentially associated with risk of paroxysmal or persistent/chronic AF. Conclusions: We observed no association between subclasses of dietary fat intake and total AF risk. Saturated fat was positively and monounsaturated fat was inversely associated with risk of persistent/chronic AF. Thus, improving dietary fat quality may help in the prevention of sustained forms of AF, which are often less amenable to treatment and associated with higher rates of morbidity. These results support AHA dietary guidelines to decrease intake of saturated fat for overall cardiovascular health.
Methodology for development of the Allergic Rhinitis and its Impact on Asthma Guideline 2008 update
Authors: J. L. Brozek, C. E. Baena‐Cagnani, S. Bonini, G. W. Canonica, G. Rasi, R. G. Van Wijk, T. Zuberbier, G. Guyatt, J. Bousquet, H. J. Schünemann
Journal: Allergy (2007)

Background: We describe the methodology for the 2008 update of the Allergic Rhinitis and its Impact on Asthma (ARIA) guidelines. The methodology differs from the 2001 edition in several respects. The most prominent change is the application of the Grading of Recommendations Assessment, Development and Evaluation (GRADE) approach to compiling evidence, assessing the quality of evidence and grading of recommendations. Methods and results: Representatives of the GRADE working group joined the ARIA guideline panel to achieve these tasks. While most recommendations result from existing systematic reviews, systematic reviews were not always available and the panel compiled the best available evidence in evidence profiles without conducting actual reviews. The panel conducted two meetings and used the GRADE criteria to assess the quality of evidence (four categories of high, moderate, low and very low) and the strength of recommendation (strong and weak) based on weighing up the desirable and undesirable effects of management strategies, considering values and preferences influencing recommendations, and resource implications. The guideline panel has chosen the words ‘we recommend’– for strong recommendations and ‘we suggest’– for weak recommendations. Both categories indicate the best course of action for a given patient population, but their implementation, requires different considerations as we describe subsequently in this article. Conclusions: The 2008 update of the ARIA guidelines has become more evidence‐based. Future iterations of the guidelines will further be improved by following the described processes even closer, such as ensuring availability of updated high quality systematic reviews for each question.
Outbreak of Rift Valley Fever—Saudi Arabia, August-October, 2000
Authors: H. Arishi, A. Ageel, M. A. Rahman, A. A. Hazmi, A. R. Arishi, B. Ayoola, C. Menon, J. Ashraf, O. Frogusin, F. Sawwan, M. Al-Hazmi, A. As-Sharif, M. Al-Sayed, A. R. Ageel, A. R. A. Alrajhi, M. A. Al-Hedaithy, A. Fatani, A. Sahaly, A. Ghelani, T. Al-Basam, A. Turkistani, N. Al-Hamadan, A. Mishkas, M. H. Al-Jeffri, Y. Y. Al-Mazroa, M. M. A. Alamri
Journal: JAMA (2000)

On September 10 2000 the Ministry of Health (MOH) of Saudi Arabia and subsequently the MOH of Yemen received reports of unexplained hemorrhagic fever in humans and associated animal deaths from the southwestern border of both countries.  Signs and symptoms of ill persons included low grade fever abdominal pain vomiting diarrhea jaundice with liver and renal dysfunction often progressing to disseminated intravascular coagulation hepatorenal syndrome and death.  This paper summarizes the preliminary results of the collaborative epidemiologic investigation performed by the Saudi Arabian MOH and other health institutions of the first confirmed occurrence of Rift Valley Fever (RVF) outside Africa.  316 persons with suspected severe RVF have been hospitalized for care and management.  Of the 316 patients 245 (78%) were male; the median age was 46 years; 15 were aged <16 years; 253 (80%) were Saudi and 63 (20%) were Yemeni citizens.  At least 66 (21%) patients have died.  Efforts of the MOH to eliminate the problem are discussed.
Abstract 3614: Anticonceptive Drug Use And Increased Carotid and Femoral Plaque Prevalence: Population Data From Asklepios
Authors: Ernst Rietzschel, Marc De Buyzere, Dirk De Baquer, Sofie Bekaert, Patrick Segers, Peter Cassiman, Pascal Verdonck, Guy De Backer, Thierry C Gillebert
Journal: Circulation (2007)

Purpose: Combination therapy with the female hormones estrogen (E) and progestins are very frequently used with approximately 100 million women worldwide taking oral contraceptives (OC). Recent trials have cast doubt on the cardiovascular safety of hormonal replacement therapy (HRT). In contrast to the HRT-controversy, little attention has been focused on OC, a therapy using 10 –100 fold higher levels of E than HRT. We describe population correlates of long-term OC use. Methods: The Asklepios study is a representative sample (2524 M/F volunteers, 35–55 years) from the Belgian general population free from overt cardiovascular disease. Vascular echography of the carotid and femoral arteries was systematically performed and atherosclerosis was defined by presence of carotid or femoral plaque. Results: Of 1301 women (median age 45.7 y), 27.4% were taking OC and 10.0% were taking HRT. In contrast, past OC-use is far more prevalent: 81% of women having taken OC for at least 1 year, with a median exposition of 13 years. After multivariate adjustment for age, smoking, blood pressure, lipids, obesity, diabetes, physical activity, fruit, vegetable and alcohol intake, educational level and drug therapy (lipid-lowering, antihypertensive, aspirin), use of OC was associated with a significant increase in carotid or femoral unilateral plaque. Odds ratio’s (OR) per 10 years of OC exposure were: carotid plaque 1.17 (1.00 –1.33) and femoral plaque 1.28 (1.10 –1.47). We also looked at prevalence of bilateral disease (involvement of right and left carotid/femoral artery) as a more stringent phenotype of atherosclerosis. OR per 10 years OC exposure were: carotid plaque 1.42 (1.03–1.84); femoral plaque 1.34 (1.05–1.63). Interpretation : Use of contraceptive therapy is very common and associated with an unexpected increase in the prevalence of carotid and femoral atherosclerosis in otherwise young, apparently healthy women. Our data suggest a 20 –30% increased prevalence of plaque in the carotid and femoral arteries per 10 years of OC exposure. In the light of widespread (&gt;80% of our population sample; &gt; 100 million women globally) and usually prolonged OC use (&gt;10 years) these results suggest OC use could be an important factor in the global atherosclerotic burden.
382. In Utero Intramuscular Delivery of a High-Capacity Adenoviral Vector Carrying a Full-Length Murine Dystrophin cDNA Provides Functional Benefit and Reassembly of the Dystrophin-Glycoprotein Complex in Hind Limb Muscles of mdx Mice
Authors: Belinda E. Peace, Jane B. Florer, George Y. Wu, Yoel Smicum, Michael W. Kilpatrick, Petros Tsipouras, Richard J. Wenstrup
Journal: Molecular Therapy (2004)
Intravenous Immunoglobulin and Quality of Life—Reply
Authors: Marinos C. Dalakas
Journal: JAMA (2004)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Relation of Chlamydia pneumoniae serology to mortality and incidence of ischaemic heart disease over 13 years in the Caerphilly prospective heart disease study Commentary: Chlamydia pneumoniae infection and ischaemic heart disease
Authors: D. P Strachan, D. Carrington, M. A Mendall, L. Ballam, J. Morris, B. K Butland, P. M Sweetnam, P. C Elwood, R. R West
Journal: BMJ (1999)

<h3>Abstract</h3> <b>Objectives:</b> To investigate the effect of <i>Chlamydia pneumoniae</i> infection on future development of ischaemic heart disease and mortality. <b>Design:</b> Prospective longitudinal study. <b>Setting:</b> Caerphilly, South Wales. <b>Subjects:</b> Plasma specimens were collected during 1979-83<sup>&nbsp;</sup>from 1773&nbsp;men aged 45-59&nbsp;years. These were tested for IgG and IgA antibodies to <i>C pneumoniae</i> (TW183) by microimmunofluorescence. <b>Outcome measures:</b> 13 year mortality and incident ischaemic heart disease events were ascertained from death certificates, hospital records, and electrocardiographic changes at follow up every 4<sup>&nbsp;</sup>to 5<sup>&nbsp;</sup>years. <b>Results:</b> 642 men (36.2%) had IgG antibodies at a titre of &lt;=1 in 16,&nbsp;of whom 362&nbsp;(20.4% of all men) also had detectable IgA antibodies. The prevalence of ischaemic heart disease (a history of past or current disease) at entry was similar at all IgG antibody titres but was positively related to IgA antibody titre. IgAantibody titre was positively correlated with plasma viscosity but not with other cardiovascular risk factors. Incidence of ischaemic heart disease was not associated with either IgG antibody titre or IgAantibody titre, but there were stronger and significant relations ofIgA antibodies with all cause mortality and fatal ischaemic heart disease, which persisted after adjustment for conventional cardiovascular risk factors. The odds ratios associated with detectableIgA antibodies were 1.07&nbsp;(95% confidence interval 0.75&nbsp;to 1.53) for all incident ischaemic heart disease, 1.83&nbsp;(1.17<sup>&nbsp;</sup>to 2.85) for fatal ischaemic heart disease, and 1.50&nbsp;(1.10&nbsp;to 2.04) for all cause mortality. <b>Conclusion:</b> This is the first prospective demonstration of an association between IgA antibodies to <i>C pneumoniae</i>, a putative marker of chronic infection, and subsequent risk of death from ischaemic heart disease. In contrast to earlier case-control studies, IgG antibodies were not associated with either prevalent or incident ischaemic heart disease.
Activin receptor signaling regulates cocaine-primed behavioral and morphological plasticity
Authors: Amy M Gancarz, Zi-Jun Wang, Gabrielle L Schroeder, Diane Damez-Werno, Kevin M Braunscheidel, Lauren E Mueller, Monica S Humby, Aaron Caccamise, Jennifer A Martin, Karen C Dietz, Rachael L Neve, David M Dietz
Journal: Nature Neuroscience (2015)
Abstract P145: Evaluating the Diagnostic Efficacy of A1C, Fructosamine and Glycated Albumin in Determining Glucose Tolerance Status in Africans: The Africans in America Study
Authors: Michelle T Duong, Caroline K Thoreson, Stephanie T Chung, Paola C Aldana, Madia Ricks, Lilian S Mabundo, David B Sacks, Anne E Sumner
Journal: Circulation (2015)

As both diabetes and pre-diabetes are common in Africa, screening tests must be rapid, simple, and accurate. Hemoglobin A1C (A1C), fructosamine, and glycated albumin (GA) are screening tests of long term glycemia which only require one blood sample obtained any time of day without consideration of recent nutrient intake. A1C is already recommended as a screening test for diabetes by the American Diabetes Association and the International Diabetes Federation, but fructosamine and GA are under active evaluation. Fructosamine is a measure of circulating glycated protein. GA is a subfraction of fructosamine. Data on the effectiveness of fructosamine and GA in African descent populations are scant. Therefore, our goal was to compare the ability of A1C, fructosamine, and GA to predict diabetes. Two hour OGTT were performed in 230 African immigrants (67% male; age 37±10y (mean±SD); BMI: 27.6±4.6 kg/m2). Glucose tolerance category was defined by 2h glucose levels (normal: 2h glucose&lt;140 mg/dL; pre-diabetes: 2h glucose ≥140 mg/dL and &lt;200 mg/dL; diabetes: 2h glucose ≥200 mg/dL). A1C was measured in all participants while fructosamine and GA levels were available in 153 of the enrollees. Pre-diabetes was identified in 26% (61/230) of the participants and diabetes was detected in 7% (15/230). By one-way ANOVA, A1C, fructosamine and GA were higher if diabetes was present (all P&lt;0.01) but did not differ significantly in the normal and pre-diabetes categories. For the prediction of diabetes, area under the receiver operator characteristic (AUC-ROC) curves was higher for GA than either fructosamine or A1C (Table). Overall, in African immigrants, each of the three tests was able to identify diabetes, but none were able to distinguish between normal glucose tolerance and pre-diabetes. Among the three tests, GA may be the best predictor of diabetes.
A SIMPLE POLYURETHANE MATRIX PROMOTES HEPATIC ENDODERM VIABILITY AND INDUCIBLE DRUG METABOLISM: IMPLICATIONS FOR DRUG TOXICOLOGY TESTING AND THE DESIGN OF LIVER SUPPORT DEVICES
Authors: David C. Hay, Salvatore Pernagallo, Juanio Diaz-Mochon, Joerg Schrader, Judy Fletcher, Donna Dalgetty, Claire Medine, James R. Black, Alexandra I. Thompson, Zara Hannoun, Philip N. Newsome, Stuart J. Forbes, James A. Ross, Mark Bradley, John P. Iredale
Journal: Hepatology (2009)
The gene family
Authors: Ruth W. Craig
Journal: Seminars in Cancer Biology (1995)

Viability is a fundamental determinant of all cellular functions, and regulation of cell viability is important in shaping tissue differentiation and organism development. The genes in the bcl-2 family can profoundly influence cell viability. In addition to bcl-2, cellular genes in this family include bcl-x, bax, mcl-1, and A1 (from vertebrates), as well as ced9 (from Caenorhabditis elegans). Different members of the family exhibit a spectrum of activity, ranging from survival-enhancement to death-enhancement. Thus, the combinatorial effects of various bcl-2 family members may allow a fine level of control over the important function of cell viability. In addition, alterations in these genes may cause aberations in cell death and thus contribute to cancer.
A Worldwide Observational Registry Collecting Longitudinal Data on Management of Chronic Myeloid Leukemia Patients (The WORLD CML Registry) – 2nd Annual Interim Analysis
Authors: Ricardo Pasquini, Jorge Cortes, Hagop M. Kantarjian, David Joske, Luis A Meillon, Lidia Mongay, John Reynolds, Timothy Hughes, Dong-Wook Kim
Journal: Blood (2010)
Küçük Hücre Dışı Akciğer Kanserinde Pnömonektomi Alternatifi Olarak Sleeve Lobektomi
Authors: Joon Suk Park, Hee Chul Yang, Hong Kwan Kim, Kwhanmien Kim, Young Mog Shim, Yong Soo Choi, and Jhingook Kim
Journal: Journal of Thoracic Oncology (2010)
Abstract 280: Cancer risk in World Trade Center rescue and recovery workers
Authors: Paolo Boffetta, Samara Solan, Sylvan Wallenstein, Roberto Lucchini, Philip Landrigan
Journal: Cancer Research (2014)

Abstract Objective: The purpose of this investigation was to evaluate cancer incidence in responders during the first 7 years after 11 September 2001. Methods: Cancers among 20,984 consented participants in the WTC Health Program were identified through linkage to state tumor registries in New York, New Jersey, Connecticut, and Pennsylvania. The follow-up lasted until 2008. Standardized incidence ratios (SIRs) were calculated to compare cancers diagnosed in responders to predicted numbers for the general population. Multivariate regression models were used to estimate associations with degree of exposure. Results: A total of 575 cancers were diagnosed in 552 individuals. Increases above registry-based expectations were noted for all cancer sites combined (SIR = 1.15; 95% CI: 1.06, 1.25), thyroid cancer (SIR = 2.39; 95% CI: 1.70, 3.27), prostate cancer (SIR = 1.21; 95% CI: 1.01, 1.44), combined hematopoietic and lymphoid cancers (SIR = 1.36; 95% CI: 1.07, 1.71), and soft tissue cancers (SIR = 2.26; 95% CI: 1.13, 4.05). When restricted to 302 cancers diagnosed ≥ 6 months after enrollment, the SIR for all cancers decreased to 1.06 (95% CI: 0.94, 1.18), but thyroid and prostate cancer diagnoses remained greater than expected. All cancers combined were increased in very highly exposed responders and among those exposed to significant amounts of dust, compared with responders who reported lower levels of exposure. Conclusion: Estimates should be interpreted with caution given the short follow-up and long latency period for most cancers, the intensive medical surveillance of this cohort, and the small numbers of cancers at specific sites. However, our findings highlight the need for continued follow-up and surveillance of WTC responders. The follow-up of the cohort is currently being updated and efforts are being made to improve the assessment of exposure to carcinogens related to WTC experience. Citation Format: Paolo Boffetta, Samara Solan, Sylvan Wallenstein, Roberto Lucchini, Philip Landrigan. Cancer risk in World Trade Center rescue and recovery workers. [abstract]. In: Proceedings of the 105th Annual Meeting of the American Association for Cancer Research; 2014 Apr 5-9; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2014;74(19 Suppl):Abstract nr 280. doi:10.1158/1538-7445.AM2014-280