tbuckley/cabot-search huggingface dataset:
Development of Pernicious Anemia in a Young Patient with Chronic Ulcerative Colitis
Authors: Pasquale E. Perillie, Richard Nagler
Journal: New England Journal of Medicine (1959)

REPORTS on the concurrence of pernicious anemia and various medical disorders have been encountered with increasing frequency since the anemia was first described by Addison in 1855. In most cases the nature of these disorders has received attention because of their possible bearing on the development or course of the anemia. We have recently observed the development of pernicious anemia at an unusually early age in a patient with chronic ulcerative colitis, a condition with which it apparently has heretofore not been associated.Case ReportR.F., a 26-year-old man, was admitted to the West Haven Veterans Administration Hospital for the . . .
Bubble-Bath Cystitis
Authors: H. J. Roberts
Journal: JAMA (1967)

<h3>To the Editor:—</h3> Complaints of irritation of the female urethra and urinary bladder frequently demand therapeutic resourcefulness. Symptoms of frequency, burning on urination, and urgency may indicate potentially serious urinary tract infection, especially in diabetic women. I have encountered five women, all with diabetes, in whom longstanding urethral or bladder irritation appeared to have been precipitated or aggravated by habitual use of bubble-bath soap preparations. Two had undergone repeated urologic and gynecologic study, and in a third patient symptoms had been attributed to a Wertheim operation performed a decade earlier. Without other change in therapy, discontinuance of the bubble bath led to prompt disappearance of the urinary complaints. The mucosal irritation is attributed to the direct effect of the ingredients of the bubble bath. <h3>Case 1:—</h3> This 23-year-old school teacher was found to have a fasting blood glucose concentration of 217 mg/100 cc when first seen because of marked obesity,
Abstract LB-165: The role of sphingolipid metabolism in the treatment of acute myeloid leukemia
Authors: Eric L. Smith, Edward Schuchman, Ronald Hoffman
Journal: Cancer Research (2012)

Abstract While significant progress has been made in understanding the genetics of AML, treatment still consists of induction therapy that is toxic and not tolerated by the elderly. In this study we show in cell culture models that manipulating sphingolipid metabolism may provide a potential mechanism to increase the efficacy of induction therapy, thus possibly allowing the use of lower doses of cytotoxic chemotherapy while maintaining efficacy. Recently thousands of papers have revealed that sphingolipid metabolism has a major role in determining how a diverse group of cell types, including myeloid malignancies, respond to a variety of stresses, particularly chemotheraputics, through production of the pro-apoptotic lipid ceramide. Conversely, a downstream ceramide metabolite, sphingosine-1-phosphte (S1P), has been shown to have the opposite effect, promoting survival, multi-drug resistance, and proliferation. We hypothesize that through the use of small molecules that inhibit the metabolism of ceramide and the formation of S1P we can decrease the apoptotic threshold of leukemic cells. To investigate this we used inhibitors to two enzymes that metabolize ceramide, the ceramidase inhibitor, LCL-385, and the glucosylceramide synthase inhibitor, PDMP, as well as the sphingosine kinase inhibitor, SKI, alone and in combination with daunorubicin and cytarabine in common AML cell culture models, HL-60 and HEL. We found that at low nanomolar concentrations each of these inhibitors alone dramatically decreases proliferation and increases apoptosis in both cell types in a dose dependant manner. Most importantly, through analysis with the Chou and Talalay combination index model, we have shown that each of these molecules works synergistically with daunorubicin and cytarabine (see table below). This data highlights the importance of sphingolipid metabolism in the response of AML cells to chemotherapy and as a potential synergistic target for induction therapy. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 103rd Annual Meeting of the American Association for Cancer Research; 2012 Mar 31-Apr 4; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2012;72(8 Suppl):Abstract nr LB-165. doi:1538-7445.AM2012-LB-165
The Amsterdam Alexithymia Scale: Its Psychometric Values and Correlations with Other Personality Traits
Authors: Bob Bermond, Harrie C.M. Vorst, Ad J.J.M. Vingerhoets, Welmoet Gerritsen
Journal: Psychotherapy and Psychosomatics (1999)

&lt;i&gt;Background:&lt;/i&gt; This article describes the construction and validation of the Amsterdam Alexithymia Scale (AAS) and explores some of the nomological net of alexithymia. &lt;i&gt;Methods:&lt;/i&gt; Four correlational studies are presented. The internal structure of the AAS is explored by factor analyses on items. Correlations of the AAS with sex and (Guilford) intellectual abilities are established. Mean scores of three different professional groups are compared. Correlations between the AAS and several clinical and personality scales are determined. Students served as subjects in all studies (347&lt;n&lt;559). &lt;i&gt;Results:&lt;/i&gt; The 20-item AAS has a stable 5-factor structure, covering 5 defining features of alexithymia: difficulties in, respectively, experiencing emotions, fantasizing, analyzing emotions, differentiating between emotions and verbalizing emotions. The AAS showed to be reliable. The AAS scores were independent of verbal and nonverbal IQ. As expected, the AAS scores turned out to be significantly lower in a group of dramatic art students and significantly higher in a group of math and artificial intelligence students, when compared to psychology students. The AAS scores correlated negatively with extroversion, positively with social inadequacy and not with neuroticism. Finally, correlations between the AAS and the Adjective Check List scores indicated that alexithymia is associated with, respectively, a neglect of own needs and impulses, a reduced capability to understand social situations and a tendency to stick to rules rigidly, to flee into social isolation, to be submissive, to avoid commitment and to experiences of lack of personal meaning in life. &lt;i&gt;Conclusion:&lt;/i&gt; The AAS is the first instrument measuring the 5 defining features of alexithymia reliably and validly.
Which Journals Have the Greatest Impact?
Authors: JOEL D. HOWELL
Journal: Annals of Internal Medicine (1986)

Letters and Corrections1 December 1986Which Journals Have the Greatest Impact?JOEL D. HOWELL, M.D., SUSAN BLITZ, M.D.JOEL D. HOWELL, M.D.Search for more papers by this author, SUSAN BLITZ, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-105-6-975_2 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: In analyzing the relative impact of medical journals, Dr. Garfield gave greater weight to articles that had more than 1 author than he did to those with a single author (1). Although we agree with a rating system that downgrades anonymous articles, we fail to see why multiple authorship need indicate higher quality. Moreover, such a rating system encourages a trend already bemoaned by many observers, including Dr. Garfield—the rapid growth in the number of authors per paper (2-5). Major medical journals, including many highly rated ones (1), routinely publish articles with 10, 12, or 14 authors,...References1. GARFIELD E. Which medical journals have the greatest impact? Ann Intern Med. 1986; 105:313-20. LinkGoogle Scholar2. Who should be an author. Br Med J 1983;287:1569-70. CrossrefMedlineGoogle Scholar3. HUTH E. Authorship from the reader's side. Ann Intern Med. 1982;97:613-4. LinkGoogle Scholar4. BURMAN K. Hanging from the masthead: reflections on authorship. Ann Intern Med. 1982;97:602-5. LinkGoogle Scholar5. GARFIELD E. More on the ethics of scientific publication: abuses of authorship attribution and citation amnesia undermine the reward system of science. Curr Contents. 1982;25(30):5-10. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: University of Michigan Medical Center Ann Arbor, MI 48109 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByQuantitative studies of science a current bibliography 1 December 1986Volume 105, Issue 6Page: 975-976 Issue Published: 1 December 1986 PDF DownloadLoading ...
Partnerships in Patient Care: A Contractual Approach
Authors: TIMOTHY E. QUILL
Journal: Annals of Internal Medicine (1983)

A contractual approach to forming a partnership between doctor and patient is presented in both theoretical and practical terms. Four basic contractual assumptions underly the doctor-patient relationship: both the doctor and the patient have unique responsibilities; the relationship is consensual, not obligatory; both doctor and patient must be willing to negotiate; and each must gain something in the encounters. Clinical examples are used to show practical implications of this model. Although explicit contracts are not needed for all patients, a contractual analysis of doctor-patient interactions helps both participants share the responsibility for patient care.
ED-07 * TRENDS IN CENTRAL NERVOUS SYSTEM TUMOR INCIDENCE RELATIVE TO OTHER COMMON CANCERS IN ADULTS, ADOLESCENTS, AND CHILDREN IN THE UNITED STATES, 2000-2010
Authors: H. Gittleman, Q. Ostrom, C. Rouse, J. Dowling, P. de Blank, C. Kruchko, B. Elder, S. Rosenfeld, W. Selman, A. Sloan, J. Barnholtz-Sloan
Journal: Neuro-Oncology (2014)

SIGNIFICANCE: Time trends in cancer incidence rates (IR) measure the changing burden of cancer on a population over time. Overall IR of cancer in the US is declining, but trends in common cancers may obscure trends in rare cancers that contribute disproportionately to mortality and morbidity. We examined incidence time trends of the most common cancers in children, adolescents, and adults between 2000 and 2010 as compared to central nervous system tumors (CNST). METHODS: Data from the United States Cancer Statistics and the Central Brain Tumor Registry of the United States were used to analyze incidence trends by selected histologies and age. Age-adjusted IR per 100,000 population with 95% confidence intervals (95% CI) and Annual Percent Change (APC) with 95% CIs were calculated for CNST and selected common cancers overall, by age, gender, race/ethnicity, selected CNST histologies, and CNST malignancy status. RESULTS: In adults, there were significant decreases in malignant CNST (2008-2010: APC = -3.1), colon (2000-2010: APC = -3.1), breast (2000-2010: APC = -0.8), lung (2000-2010: APC = -1.1), and prostate cancer (2000-2010: APC = -2.4), but a significant increase in non-malignant CNST (2004-2010: APC = 2.7). In adolescents, there were significant increases in malignant CNST (2000-2008: APC = 1.0) and non-malignant CNST (2004-2010: APC = 3.9). In children, there were significant increases in malignant CNST (2000-2010: APC = 0.6), acute lymphocytic leukemia (2000-2010: APC = 1.0), and non-Hodgkin lymphoma (2000-2010: APC = 0.6). CONCLUSIONS: Between 2000 and 2010, there were significant decreases in malignant CNST and other common cancers in adults, significant increases in malignant CNST in adolescents, significant increases in malignant CNST and other common cancers in children, and significant increases in non-malignant CNST in adults and adolescents. Surveillance of IR trends is an important way to measure the changing public health and economic burden of cancer; histology-specific analyses are essential to measure the potential disproportionate impact of rare cancers.
662 DO 4LOG10 IU/L SERUM HBV-DNA AND NORMAL ALANINE AMINOTRANSFERASE (ALT) LEVELS IDENTIFY CLINICALLY SIGNIFICANT HBEAG NEGATIVE CHRONIC HEPATITIS B (CHB) LIVER DISEASE IN HONG KONG?
Authors: N. Leung, C. Yeung, R. Chan, S.M. Au, H. Poon, A.J. Hui
Journal: Journal of Hepatology (2008)
CS gas is not a chemical means of restraining a person
Authors: P. J Gray
Journal: BMJ (1997)

Introducing the postoperative care team Effective postoperative care remains surgeons' roleEditor-I am concerned that the suggestions made by David R Goldhill might be taken too seriously rather than remain a point for discussion. 1 Goldhill is right in his assertion that patients can fare badly in their postoperative course because of lack of attention by their attendants and lack of understanding of common postoperative complications.I believe, however, that he has missed the opportunity to lay the blame at the correct door.Surely it is the surgeons' role to carry out preoperative assessment, surgery, and effective postoperative care.If they choose to emphasise their importance in the operating theatre, delegating their other responsibilities to their trainees, the nurse practitioners, and the anaesthetists, why should we encourage this path?Undoubtedly, anaesthetists are fast becoming the new generalists, with an increasing role outside the operating theatre.These new skills and responsibilities include pain control, intensive care, and transoesophageal echocardiography, to name but a few.Some of my professional colleagues may relish even more diversification and abhor my comments.Goldhill implies that anaesthetists and postoperative care nurses will lead the postoperative care team; indeed, this is already happening in North America, where they have been sent to run preoperative assessment clinics by surgeons based in the operating room.If the surgical ward round in your hospital has become a quick look through the laboratory results and a glance at the chest radiograph before a rush to the changing rooms then I suggest that waiting for the confidential inquiry into perioperative deaths to point out the obvious is not the solution.
Improvements in Surgical Results for Lung Cancer from 1989 to 1999 in Japan
Authors: Teruaki Koike, Yasushi Yamato, Hisao Asamura, Ryosuke Tsuchiya, Yasunori Sohara, Kenji Eguchi, Masaki Mori, Yoichi Nakanishi, Tomoyuki Goya, Yoshihiko Koshiishi, Etsuo Miyaoka
Journal: Journal of Thoracic Oncology (2009)
Genes, Cancer Risks, and Clinical Outcomes
Authors: Patricia Hartge
Journal: New England Journal of Medicine (2007)

Learning whether a patient who has just been given a diagnosis of breast cancer also bears one of the cancer-causing mutations in the BRCA1 or BRCA2 genes may add little to the clinician's ability to select a therapy or predict the course of disease, once the grade and receptor status of the tumor and the age of the patient are taken into account. In this issue of the Journal, Rennert et al.1 support that line of reasoning with their study of Israeli women in whom breast cancer was diagnosed in 1987 or 1988. Reliable data on clinical outcomes in carriers . . .
P1236 NS3, NS5A AND NS5B COEVOLUTION DURING TREATMENT WITH FIRST-GENERATION PROTEASE INHIBITORS
Authors: V.C. Di Maio, V. Cento, D. Di Paolo, R. Campoli, K. Yu, A. Manunta, V. Micheli, M. Tontodonati, F. De Leonardis, A. Bertoli, F.P. Antonucci, L. Nosotti, C. Sarrecchia, C. Magni, J. Vecchiet, M.S. Mura, M. Andreoni, G. Parruti, S. Babudieri, G. Rizzardini, M. Angelico, C.F. Perno, F. Ceccherini-Silberstein
Journal: Journal of Hepatology (2014)
Review: Apixaban reduces bleeding and mortality compared with vitamin K antagonists
Authors: Thomas DeLoughery
Journal: Annals of Internal Medicine (2015)

Source Citation Touma L, Filion KB, Atallah R, Eberg M, Eisenberg MJ. A meta-analysis of randomized controlled trials of the risk of bleeding with apixaban versus vitamin K antagonists. Am J Cardiol. 2015;115:533-41. 25547937
How Does Provider and Patient Awareness of High-Risk Status for Lower-Extremity Amputation Influence Foot-Care Practice?
Authors: Michael A Del Aguila, Gayle E Reiber, Thomas D Koepsell
Journal: Diabetes Care (1994)

OBJECTIVE To assess whether patients with diabetes at high risk for lower extremity amputation received more intensive medical care or self-care instruction and to determine the association between foot care and risk of lower-extremity amputation. RESEARCH DESIGN AND METHODS Patients with diabetes were seen at the Seattle Veterans Affairs Medical Center (VAMC) between October 1984 and April 1987; 67 patients were seen for initial non-traumatic amputation, and 236 consecutive control subjects were seen for non-traumatic but medically necessary surgery unrelated to diabetes. Data collection included patient interview and medical record review. High-risk status, defined as presence of peripheral neuropathy, peripheral vascular disease, or prior foot ulcer, was temporally fixed at 2 years before study enrollment. RESULTS Peripheral neuropathy, peripheral vascular disease, and prior foot ulcer were independently associated with risk of lower-extremity amputation: peripheral neuropathy odds ratio (OR) = 1.4 (95% confidence interval (CI) 0.7-2.7), peripheral vascular disease OR = 2.6 (95% CI 1.5-4.5), and prior foot ulcer OR = 10.9 (95% CI 4.6-25.5). Patients with a prior foot ulcer were significantly more likely to have seen a podiatrist and to have received outpatient diabetes education at the Seattle VAMC; their providers were more likely to prescribe clipping toenails, regular foot washing, and elevating feet during the day (X12 for proportions P &amp;lt; 0.05). However, for patients with a history of peripheral neuropathy or peripheral vascular disease, there was no statistically significant increase in medical care (podiatry visits, outpatient diabetes education) or self-care instruction (clip nails, elevate feet, or self-monitor blood glucose) compared with patients without either of these two conditions (x12 for proportions P &amp;gt; 0.20). CONCLUSIONS When clinicians were aware of a patient's very elevated risk for lower-extremity amputation (evidenced by prior history of foot ulcer), they were more likely to prescribe preventive foot-care behaviors, but awareness of other risk factors (peripheral neuropathy or peripheral vascular disease) did not necessarily increase preventive care. Physicians and patients should receive periodic education and reinforcement of diabetes management skills to modify care delivered to individuals at highest risk for lower-extremity amputation.
TECHNIC OF THERAPEUTIC EXERCISE
Authors: J. S. COULTER
Journal: JAMA (1930)

Therapeutic exercise is the scientific supervision of bodily movement, with or without apparatus, for the distinct purpose of restoring normal function to diseased or injured tissues. There are two types of therapeutic exercise—passive and active. Passive exercise is that form of bodily movement which is carried through by the operator without the assistance or resistance of the patient. Mennell<sup>1</sup>uses the term relaxed movement. Passive movement should be administered with great care, with the arm or leg to be manipulated rightly held and the patient completely relaxed and pumping movement avoided. The occurrence of a muscle spasm is a danger signal. If such a spasm occurs the operator should stop immediately. It should be remembered that a slight tightening of the muscles precedes pain. Therefore, to secure the best results all movements should be well within the limit at which pain occurs. It should be kept constantly in mind
Detection and Localization of Gastrointestinal Bleeding Using Tc-99m-Pyrophosphate In Vivo Labeled Red Blood Cells
Authors: R KING SMITH, GREG ARTERBURN
Journal: Clinical Nuclear Medicine (1980)

Eighteen patients with either clinically or laboratory-detectable gastrointestinal bleeding were studied using Tc-99m-PYP in vivo labeled red blood cells. In those patients with massive gastrointestinal bleeding, the site of bleeding was usually detected within the first half-hour of scanning. Slower bleeding required longer scanning time. In several patients, bleeding sites were detected which could not be located by other means. It was experimentally determined that as little as 5 ml of ingested whole blood labeled in vivo with Tc-99m-PYP could be detected in the upper gastrointestinal tract.
Neck Masses and Skin Lesions in an Oriental
Authors: Karl T. Benedict
Journal: JAMA (1970)

Dr. Philip M. Hatfield: The patient is a 29-year-old Oriental man who complained of lumps on both sides of his neck. These were not painful and had been present for at least six weeks. He had difficulty swallowing and had lost an undetermined amount of weight. Multiple, nontender skin lesions had been present on the trunk for many months. Physical examination disclosed large, nontender, fluctuant masses laterally on both sides of the patient's neck, extending to the angle of the mandible on the right. A similar mass was present over the anterior portion of the left side of the chest, and in his right buttock a small sinus tract was noted, from which drained a foul-smelling pus. Firm, 1.5-cm nodules were palpable in both testes. Both lateral lobes of his prostate were enlarged, hard, and nodular. The results of the remainder of physical examination were normal, without other adenopathy. Laboratory
ON THE FLAGELLATION OF LYMPHOCYTES IN THE PRESENCE OF EXCITANTS BOTH ARTIFICIAL AND CANCEROUS
Authors: H. C. Ross, C. J. Macalister
Journal: BMJ (1909)

number of fits was progressive from 25 to 48.At this stage-namely, November, 1907-the administration of the bromide salt was begun, and the results are seen in the following table : TABLE II.
US Registry for Sudden Death in the Young Launched by the NIH and CDC
Authors: Mike Mitka
Journal: JAMA (2013)

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Insurance for Long-Term Care
Authors: Anne R. Somers
Journal: New England Journal of Medicine (1987)

IS insurance for long-term care an idea whose time has come? Possibly. The recent explosion of publicity about insurance against catastrophic illness in the elderly, President Reagan's partial endorsement of Secretary Bowen's report favoring such insurance,1 , 2 and the striking number of related proposals, conferences, committees, bills and congressional hearings indicate widespread public interest. The American Association of Retired Persons (which has 25 million members) says that "safeguarding older Americans from the fear of catastrophic health costs" is its "top legislative priority for 1987."3 But the excitement and activity also conceal wide differences in definition of the basic problem, as well . . .