tbuckley/cabot-search huggingface dataset:
Abstract P2-07-07: Prostaglandin E receptor 2 (EP2) regulates breast cancer stem-cell like property and promotes epithelial-mesenchymal transition
Authors: Vivian Y Shin, Man T Siu, John C Ho, Isabella Cheuk, Jiawei Chen, Ava Kwong
Journal: Cancer Research (2015)

Abstract Background: Presence of cancer stem-like cells (CSCs) is the main obstacle for poor treatment response and mortality in breast cancer patients. Prostaglandin E receptors have been reported to play a role in epithelial-mesenchymal transition (EMT) and metastasis, however, the contribution on cancer stem cell compartment remains unstudied. Methods: Human xenograft breast cancer model was used to study the expression of EP receptors during cancer development. Construction of stable EP2-expression cells was used to study tumorigenesis and characterization of EP2 receptor. Functional role of EP2 receptor on cell proliferation, flow cyometry, invasion and EMT gene expression array were performed in transfected cells. Expression of EP2 receptor was compared in primary tumor tissues by immunostaining and real-time PCR. Results: EP2 receptor was predominantly expressed in animal tissues during cancer development, as well as in human primary tumor tissues. In mouse xenograft model, MB-231-EP2 clone developed a more aggressive tumor with a larger tumor size and showed a significant increase in cancer stem cell marker aldehyde hydrogenase (ALDH1) expression. In vitro study, MB-231-EP2 clone increased colony formation capacity and S-phase entry by the regulation of E-cadherin, TWIST1 and ALDH1. Importantly, we found that Twist1 expression level was higher in breast cancer patients than healthy controls and was associated with ALDH1 expression. Conclusions: These findings implicated that EP2 receptor was crucial to nurture CSC phenotype and promote tumorigenesis in breast cancer. Blocking of EP2 might be a potential therapeutic strategy to improve treatment response for breast cancer patients. Citation Format: Vivian Y Shin, Man T Siu, John C Ho, Isabella Cheuk, Jiawei Chen, Ava Kwong. Prostaglandin E receptor 2 (EP2) regulates breast cancer stem-cell like property and promotes epithelial-mesenchymal transition [abstract]. In: Proceedings of the Thirty-Seventh Annual CTRC-AACR San Antonio Breast Cancer Symposium: 2014 Dec 9-13; San Antonio, TX. Philadelphia (PA): AACR; Cancer Res 2015;75(9 Suppl):Abstract nr P2-07-07.
Abstract 19519: Closing the Cardiac Intensive Care Unit: Cost-Savings Associated with a “Closed” versus “Open” Model of Critical Care Delivery
Authors: Arun K Das, Jacqueline M Harden, Mathi M Ravichandran, Anton Lishmanov, Linda Raftery, Sean van Diepen, Jason N Katz
Journal: Circulation (2014)

Introduction: A recent AHA scientific statement highlighted the evolving complexity of critical care delivery for cardiac patients, and the emerging need for novel staffing models. In this document, a “closed” unit structure - in which a dedicated intensive care team treats all admitted patients - was specifically advocated. However, in light of escalating critical care costs within US hospitals, there is a pressing need to better understand the financial impact of different care platforms. Methods: In July 2013, our academic cardiac intensive care unit (CICU) was transitioned from an “open” to a “closed” model of care. In a before-and-after study design, consecutive admission records were reviewed from Aug 2012-Dec 2012 (“open” unit) and from Aug 2013-Dec 2013 (“closed” unit). Routinely collected financial and demographic data were examined, and the impact of case-mix index (CMI) on cost was evaluated. Results: In the “open” and “closed” models, there were 333 patient-visits accounting for 1,891 patient-days and 397 visits accounting for 2,558 patient-days, respectively. While demographics, payor mix, and fixed vs. variable cost distribution were unchanged (Table), the total cost-per-patient and cost-per-patient-day were lower within the “closed” CICU ($8,676 vs. $10,118 and $1,346 vs. $1,782, respectively) despite a greater average CMI (4.6 vs. 3.6). Total and 30d CICU readmission rates were also lower in the “closed” unit (Table). Readmissions in the "closed" unit resulted in greater cost-per-patient-day than new admits ($1,576 vs. $1,339). Conclusions: A “closed” CICU staffing model is associated with lower health care costs. This may be partly explained by lower CICU recidivism, but likely is multifactorial. Additional study will focus on the influence of resource use, critical care delivery to key sub-populations, and the development of effective strategies for further cost containment.
Cartilaginous matrix-producing apocrine carcinoma of the skin
Authors: N. Misago, S. Aoki, Y. Shinoda, S. Toda, Y. Narisawa
Journal: British Journal of Dermatology (2010)

Conflicts of interest: none declared. Madam, Matrix‐producing carcinoma of the breast (MPCB) is an extremely rare subtype of metaplastic carcinoma defined as an invasive breast carcinoma with a direct transition from carcinoma to cartilaginous or osseous matrix without an intervening spindle‐cell component.1, 2 Primary cutaneous apocrine carcinoma is a rare adnexal carcinoma, which is analogous to breast carcinoma.3, 4 We report the first case of matrix‐producing apocrine carcinoma of the skin, which is distinct from a malignant mixed tumour of the skin (malignant chondroid syringoma).5 An 84‐year‐old woman presented with a recent growth of a nodule that had appeared on her upper left arm 1 year earlier. Examination revealed an erythematous, firm nodule on the outer side of her upper arm, measuring 2·5 × 2·2 cm in size, with an overlying irregular surface (Fig. 1a). An extensive work‐up revealed no evidence of visceral malignancy, including any primary carcinoma of the breast. The nodule was completely excised with the removal of a sentinel lymph node in the left axilla. Neither recurrence nor metastasis has been observed in the subsequent 2 years.
866. Modification of the Expression Vector for Systemic Gene Therapy of MLD
Authors: Yukiko Takakusaki, Sanae Hisayasu, Atsushi Watanabe, Takashi Shimada
Journal: Molecular Therapy (2004)

Metachromatic leukodystrophy (MLD) is a lysosomal storage disorder caused by a deficiency of arylsulfatase A (ASA). Progressive demyelination associated with accumulation of sulfatide results in a variety of neurologic symptoms. No effective therapy is available at this moment. Gene therapy may be an important option for treatment of MLD. Since sulfatide deposits in both the central and peripheral nervous system, local injection of ASA expression vectors may have limited merit. In order to establish a systemic gene therapy protocol for MLD, we modified the ASA expression vector. First, we tested the utility of SUMF1 for overexpression of functional ASA. SUMF1 is a post-translational modifying enzyme essential for sulfatase activity. Coexpression of SUMF1 with ASA in 293 cells resulted in a several folds increase of ASA activity. When the ASA and SUMF1 expression plasmids were injected into liver by the hydrodynamics-based technique, a striking synergistic increase of ASA activity was observed in both liver and serum. Second, we synthesized the ASA-Tat fusion protein to improve the biodistribution of the enzyme. It was reported that the Tat motif (YGRKKRRQRRR) allows the fusion protein to cross the cell membrane and the blood brain barrier. The ASA-Tat fusion protein had full ASA activity and was secreted from cells transfected with the expression vector. When the conditioned media were incubated with MLD patient's fibroblasts, the ASA-Tat was efficiently taken up to the cells, but its uptake was only partially inhibited by the addition of mannose 6 phosphate (M6P). The M6P independent uptake of ASA-Tat was also confirmed by immunohistochemical staining. These results suggest that combination of SUMF1-coexpression and Tat-modification may be important for systemic delivery of ASA for MLD gene therapy.
Hyposensitization in Childhood Hay Fever
Authors: N.‐I. M. Kjellman, A. Lanner
Journal: Allergy (1980)

Thirty-six children with well-defined criteria for hay fever (mean age 8 and range 4-15 years) were allocated at random for hyposensitization (HS) with a refined (R) or whole (W) timothy pollen extract during 3-4 years. HS was performed as rush HS with the patients hospitalized for about 1 week and thereafter with monthly injections. Scores for symptoms and antihistamine use were recorded during the season before HS and all seasons during HS. Skin and conjunctival tests were made at the start of HS and postseasonally. Blood samples for IgE and IgG measurements were drawn before and during rush HS and pre- and postseasonally each year. The R-group patients tolerated a higher allergen dose at the end of the rush HS than the W-group ones. They also demonstrated a higher, significant increase in total and specific IgE levels within 7 days and specific IgG levels within 60 days after the start of HS. In both groups postseasonal increases in total and specific IgE levels were seen. The IgG levels increased successively during the treatment. The most remarkable difference between the groups was in scores for symptoms and antihistamine use, which in group R decreased significantly while they increased significantly in group W. Based on these data we recommended that HS, if indicated, should be performed with purified allergen extracts.
Observations On Pneumococcus Type III Pneumonia
Authors: Francis G. Blake
Journal: Annals of Internal Medicine (1931)

Article1 December 1931Observations On Pneumococcus Type III PneumoniaFRANCIS G. BLAKE, A.B., M.D., F.A.C.P.FRANCIS G. BLAKE, A.B., M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-5-6-673 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptDuring the last two decades there has been a gradually but steadily increasing tendency to classify pneumonia on an etiological basis rather than on the older, anatomical basis of Laënnec; or at least, if the anatomical terms of lobar and bronchopneumonia are retained, to qualify them by an additional etiological diagnosis. This change which has taken place in the classification of pneumonia has undoubtedly occurred because of the increasing recognition of the fact that pneumonia comprises in reality a considerable group of quite different and distinct infectious diseases hitherto all classified under one or the other of two headings—lobar or...References1 CECIL RL: The etiology of pneumonia, Am. Jr. Med. Sci., 1922, clxiv, 58-65. CrossrefGoogle Scholar2 COLE RI: Acute pulmonary infections, DeLamar Lecture, 1928, Williams and Wilkins Company, Baltimore. Google Scholar3 STILLMAN EG: A contribution to the epidemiology of lobar pneumonia, Jr. Exper. Med., 1916, xxiv, 651-670. STILLMAN, E. G.: Further studies on the epidemiology of lobar pneumonia, Jr. Exper. Med., 1917, xxvi, 513-535. CrossrefGoogle Scholar4 CECILBALDWINLARSEN RLHSNP: Lobar pneumonia; clinical and bacteriologic study of 2000 typed cases, Arch. Int. Med., 1927, xl, 253-280. CrossrefGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: New Haven, Conn.*From the Department of Internal Medicine, Yale University School of Medicine and the Medical Service of the New Haven Hospital.†Read at the Baltimore Meeting of the American College of Physicians, March 25, 1931. Nextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byDeath or survival from invasive pneumococcal disease in Scotland: associations with serogroups and multilocus sequence typesSimultaneous Nasopharyngeal Carriage of Two Pneumococcal Multilocus Sequence Types with a Serotype 3 PhenotypePneumococcal endocarditis 1 December 1931Volume 5, Issue 6Page: 673-686KeywordsHospital medicineInfectious diseasesMedical servicesPneumococcusPneumonia ePublished: 1 December 2008 Issue Published: 1 December 1931 PDF downloadLoading ...
PKC-β controls IκB kinase lipid raft recruitment and activation in response to BCR signaling
Authors: Thomas T. Su, Beichu Guo, Yuko Kawakami, Karen Sommer, Keun Chae, Lisa A. Humphries, Roberta M. Kato, Shin Kang, Lisa Patrone, Randolph Wall, Michael Teitell, Michael Leitges, Toshiaki Kawakami, David J. Rawlings
Journal: Nature Immunology (2002)
Improving the Quality of Life at the End of Life
Authors: Rita Rubin
Journal: JAMA (2015)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Trend of Histone Deacetylase Inhibitors in Cancer Therapy: Isoform Selectivity or Multitargeted Strategy
Authors: Lei Zhang, Yantao Han, Qixiao Jiang, Chunbo Wang, Xuehong Chen, Xiaoguang Li, Fuming Xu, Yuqi Jiang, Qiang Wang, Wenfang Xu
Journal: Medicinal Research Reviews (2014)

Abstract Pharmacological inhibition of histone deacetylases (HDACs) has been successfully applied in the treatment of a wide range of disorders, including Parkinson's disease, infection, cardiac diseases, inflammation, and especially cancer. HDAC inhibitors (HDACIs) have been proved to be effective antitumor agents by various stages of investigation. At present, there are two opposite focuses of HDACI design in the cancer therapy, highly selective inhibitor strategy and dual‐ or multitargeted inhibitors. The former method, which is supposed to elucidate the function of individual HDAC and provide candidate inhibitors with fewer side effects, has been widely accepted by the inhibitor developer. The latter approach, though less practiced, has promising potential for the antitumor therapy based on HDACIs. Effective HDACIs, some of which are in clinic anticancer research, have been developed by both methods. In order to gain insight into HDACI design, the strategies and achievements of the two diverse methods are reviewed.
PDE3A mutations cause autosomal dominant hypertension with brachydactyly
Authors: Philipp G Maass, Atakan Aydin, Friedrich C Luft, Carolin Schächterle, Anja Weise, Sigmar Stricker, Carsten Lindschau, Martin Vaegler, Fatimunnisa Qadri, Hakan R Toka, Herbert Schulz, Peter M Krawitz, Dmitri Parkhomchuk, Jochen Hecht, Irene Hollfinger, Yvette Wefeld-Neuenfeld, Eireen Bartels-Klein, Astrid Mühl, Martin Kann, Herbert Schuster, David Chitayat, Martin G Bialer, Thomas F Wienker, Jürg Ott, Katharina Rittscher, Thomas Liehr, Jens Jordan, Ghislaine Plessis, Jens Tank, Knut Mai, Ramin Naraghi, Russell Hodge, Maxwell Hopp, Lars O Hattenbach, Andreas Busjahn, Anita Rauch, Fabrice Vandeput, Maolian Gong, Franz Rüschendorf, Norbert Hübner, Hermann Haller, Stefan Mundlos, Nihat Bilginturan, Matthew A Movsesian, Enno Klussmann, Okan Toka, Sylvia Bähring
Journal: Nature Genetics (2015)
A comparison of the rate of refractive growth in pediatric aphakic and pseudophakic eyes 1 1No author has a financial interest in the subject matter of the manuscript. No author has a financial interest in the Pediatric IOL Calculator. 2 2The opinions expressed in this paper are solely those of the authors, and do not reflect the official policy or position of the Department of the Navy, Department of the Defense, or the US Government.
Authors: Scott K McClatchey, Elie Dahan, Eduardo Maselli, Howard V Gimbel, M.Edward Wilson, Scott R Lambert, Edward G Buckley, Sharon F Freedman, David A Plager, Marshall M Parks
Journal: Ophthalmology (2000)
Genetic Counseling for Families of Patients With Fragile X Syndrome
Authors: Shannon K. Barrett, Tamara Drazin, Deborah Rosa, Gabriel S. Kupchik
Journal: JAMA (2004)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Stars disappear
Authors: DS Khursandi
Journal: BMJ (1998)

# Stars disappear {#article-title-2}

Why do I write? Because my mother killed herself. Twenty five years ago, one sunny autumn afternoon my father was mowing the lawn. My mother went down to the dank cellar of their Georgian house. She looped a belt around her neck, tied the other end to a beam, and stepped off a chair. She was 60. Because mental illness remains an unmentionable topic. Because sharing my experience may give you some insight into depression—30% of you may have this disease. Because I am alive today due to her suicide.

What happened to me? Twelve years ago, after a long crescendo of stress, I stopped singing and started to cry—at night, while driving, at work—in fact anywhere and any time when my brain was not actively engaged. My attention in theatre was not significantly affected, but I watched the patient and the monitors through a veil of tears. Few knew how I was feeling—I was very good at covering up. Pain took up residence in my chest, lodged stubbornly beneath my sternum, and stayed for three years: an overwhelming ache, a tight band, a pervasive feeling of doom.

The evenings were the worst. I couldn't sleep; I woke at 4am. The hideous circuits of pain were particularly distressing at night. I resorted to sleeping tablets very early in the illness. Without sleep I could not …
Endoscopy - An Advancement in Sinus and Skull Base Surgery
Authors: Rickul Varshney, Faisal Zawawi, Marc A, Saul Frenkiel
Journal: Endoscopy (2013)

Skull base and sinus surgery has evolved dramatically throughout the past century. It is not long ago that the maxillary sinus would principally be reached via an anterior ap‐ proach through the gingivobuccal sulcus of the oral cavity. The earliest days of endos‐ copy date back to the early 1900s, when Hirschmann used a modified cystoscope to examine the sinuses. Thereafter, modern endoscopy has seen advances not only in the types of endoscopes available, but also the types of interventions amenable to the endo‐ scopic approach.
Radiologists Adjusting to Revolution in CT
Authors: Mike Mitka
Journal: JAMA (2006)

CHICAGO—The emergence of 64-slice computed tomography (CT) is shaping up to be more than simply the next stage in the evolution of noninvasive diagnostic imaging. Radiologists are viewing it as a revolution, opening the possibilities of images neither they nor referring physicians have yet considered. However, revolutions overturn the status quo and create states of chaos. For the imaging community, that means that many radiologists may not be up to speed with the capabilities of 64slice CT and therefore may be missing diagnostic opportunities. The 64-slice CT, approved by the US Food and Drug Administration in 2004, offers faster scan times, thinner CT sections, improved temporal resolution, and the opportunity for volume imaging. The shorter scan times enable CT scanners to capture high-quality “motion-free” images of the beating heart and coronary arteries, which in the past was not possible due to the longer scan times of older CT scanners (Leschka S et al. Eur Heart J. 2005;26:14821487). Thinner slicing (0.5-mm) and improved spatial resolution should lead to better “virtual colonoscopy,” which will detect smaller polyps. The technology also opens other parts of the body to noninvasive examination.
Clinical features and viral kinetics in a rapidly cured patient with Ebola virus disease: a case report
Authors: Manuel Schibler, Pauline Vetter, Pascal Cherpillod, Tom J Petty, Samuel Cordey, Gaël Vieille, Sabine Yerly, Claire-Anne Siegrist, Kaveh Samii, Julie-Anne Dayer, Mylène Docquier, Evgeny M Zdobnov, Andrew J H Simpson, Paul S C Rees, Felix Baez Sarria, Yvan Gasche, François Chappuis, Anne Iten, Didier Pittet, Jérôme Pugin, Laurent Kaiser
Journal: The Lancet Infectious Diseases (2015)
Deletion variants within the NF-kappa B activation domain of the LMP1 oncogene prevail in acquired immunodeficiency syndrome-related large cell lymphomas and human immunodeficiency virus-negative atypical lymphoproliferations
Authors: H Knecht, M Raphael, C McQuain, S Rothenberger, G Pihan, S Camilleri-Broet, E Bachmann, GR Kershaw, S Ryan, EL Kittler, PJ Quesenberry, D Schlaifer, BA Woda, P Brousset
Journal: Blood (1996)
Coeliac disease and risk of tuberculosis: a population-based cohort study
Authors: D S Sanders, J West, M K B Whyte
Journal: Thorax (2006)

Are patients with coeliac disease at higher risk of tuberculosis?

On the basis of screening studies on healthy volunteers, coeliac disease is now recognised to affect 1% of the population.1 The current optimal serological testing for coeliac disease may be immunoglobin (Ig)A endomysial, IgA tissue transglutaminase or a combination of the two, with a positive predictive value in excess of 95% provided IgA deficiency is excluded. Patients with positive serology then require an endoscopic duodenal biopsy to confirm the presence of villous atrophy and thus a firm diagnosis of coeliac disease. A link between coeliac disease and tuberculosis was first suggested as far back as 1952, but there has been a paucity of data exploring this relationship other than case reports and case series.2 The initial focus was on gastrointestinal tuberculosis being one of the differential diagnoses for villous atrophy of the small bowel. However, in 1988 a report from Birmingham, UK, suggested that patients with coeliac disease seemed to have an increased …