tbuckley/cabot-search huggingface dataset:
Hepatic and extrahepatic malignancies and primary sclerosing cholangitis
Authors: E Schrumpf
Journal: Gut (2003)

<h3>Objective:</h3> Describe the characteristics of patients diagnosed with migraine and Benign Paroxysmal Positional Vertigo (BPPV) at University of Washington Medical System. <h3>Background:</h3> Migraine and vertigo are common complaints in general population. BPPV is the most common cause of vertigo in adults. In a cohort study in South Korea, the incidence of BPPV was higher in individuals with migraine than those without (6% vs 2.3%), and a Taiwan population-based study showed that migraine patients had 2.03 times increased risk for BPPV. The prevalence of migraine in a BBPV positive study population of a large U.S neurology clinic was 25.8%. We investigated the prevalence of BBPV in migraine patients within our University of Washington patient population. <h3>Design/Methods:</h3> The Leaf research database was used to obtain retrospective data for all patients with ICD-10 code diagnoses for migraine (using ICD 10 G43.001-G43.D1), disorders of vestibular function (using ICD 10 H81.01-H81.93), and BPPV (using ICD 10 H81.10-H81.13) at the University of Washington. Demographics were analyzed. <h3>Results:</h3> The total number of patients with migraine and vestibular dysfunction were 36,498 and 9,639 respectively. 61% (5,890) of patients with disorders of vestibular function had diagnosis of BPPV. 12.2% (718) of BPPV patients were diagnosed with migraine. These 718 patients represented only 1.96% of migraine patients. Of this group, 85.2% were females and 74.1% were under 65 years old. 11.6% of this group had an Asian language as their native tongue. <h3>Conclusions:</h3> In our study population BPPV was the most common diagnosis among patients with disorders of vestibular disorders. Over ten percent of these had comorbid migraine headache. While BPPV was diagnosed in only about one percent of migraine patients in this study, it should be considered in the differential for vertigo, particularly in female patients under 65, especially since BPPV is easily diagnosed and treated. <b>Disclosure:</b> Ms. Goh has nothing to disclose. Dr. Murinova has nothing to disclose. Dr. Cuneo has nothing to disclose. Dr. Krashin has nothing to disclose.
TRIPKOLIDINE HYDROOHLORTDE IN THE PREVENTION OF SOME ROLAR DERMATOSES.
Authors: L. J. A. LOEWENTHAL
Journal: British Journal of Dermatology (1963)

Journal Article TRIPKOLIDINE HYDROOHLORTDE IN THE PREVENTION OF SOME ROLAR DERMATOSES. Get access L. J. A. LOEWENTHAL L. J. A. LOEWENTHAL South African Institute for Medical Research Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 75, Issue 6, 1 June 1963, Pages 254–256, https://doi.org/10.1111/j.1365-2133.1963.tb13560.x Published: 01 June 1963
Extraneural Pathologic Prion Protein in Sporadic Creutzfeldt–Jakob Disease
Authors: Markus Glatzel, Eugenio Abela, Manuela Maissen, Adriano Aguzzi
Journal: New England Journal of Medicine (2003)

In patients with sporadic Creutzfeldt–Jakob disease, pathologic disease-associated prion protein (PrPSc) has been identified only in the central nervous system and olfactory-nerve tissue. Understanding the distribution of PrPSc in Creutzfeldt–Jakob disease is important for classification and diagnosis and perhaps even for prevention.
Use of symptoms and signs to diagnose maxillary sinusitis in general practice: comparison with ultrasonography.
Authors: N. P. van Duijn, H. J. Brouwer, H. Lamberts
Journal: BMJ (1992)

OBJECTIVE--To establish the incidence of maxillary sinusitis in general practice and the predictive value of symptoms and signs. DESIGN--Population based study. SETTING--9 general practices with 15,220 patients aged 15 years and older on the list. PATIENTS--400 patients with 441 episodes in whom practitioners intended to confirm or to exclude sinusitis. MAIN OUTCOME MEASURES--Results of ultrasonography and signs and symptoms associated with positive results. RESULTS--212 of the 441 episodes were confirmed by ultrasonography. 15.7 episodes occurred per 1000 adults per year. The five symptoms beginning with common cold (beta coefficient = 1.035), purulent rhinorrhoea (0.996), pain at bending (0.950), unilateral maxillary pain (0.640), and pain in teeth (0.606) were associated with positive results on ultrasonography. General practitioners9 clinical diagnoses were correct in 177 episodes, false positive in 88, false negative in 22, and uncertain in 154. With an algorithm using the five weighted symptoms 243 of the diagnoses would have been correct, but 110 would remain uncertain and 44 cases would have been missed. CONCLUSION--The five symptoms algorithm would improve diagnostic accuracy of general practitioners, but incorrect and uncertain diagnoses cannot be avoided.
Recognition of the nonclassical MHC class I molecule H2-M3 by the receptor Ly49A regulates the licensing and activation of NK cells
Authors: Daniel M Andrews, Lucy C Sullivan, Nikola Baschuk, Christopher J Chan, Richard Berry, Claire L Cotterell, Jie Lin, Heloise Halse, Sally V Watt, Jennifer Poursine-Laurent, Chyung-Ru Wang, Anthony A Scalzo, Wayne M Yokoyama, Jamie Rossjohn, Andrew G Brooks, Mark J Smyth
Journal: Nature Immunology (2012)
Collagen-Specific Peptide Conjugated HDL Nanoparticles as MRI Contrast Agent to Evaluate Compositional Changes in Atherosclerotic Plaque Regression
Authors: Wei Chen, David P. Cormode, Yuliya Vengrenyuk, Beatriz Herranz, Jonathan E. Feig, Ahmed Klink, Willem J.M. Mulder, Edward A. Fisher, Zahi A. Fayad
Journal: JACC. Cardiovascular imaging (2013)
Basic Gastro-Enterology, Including Diseases of the Liver
Authors: William F. Lipp
Journal: JAMA (1966)

With considerable ingenuity the authors have prepared a short introduction to the field of gastroenterology, surprising in its simplicity and clarity. Unfortunately, the purpose of the book has limited its area of usefulness. Neither a textbook nor a reference work, the book was written to help young physicians learn basic principles and facts. The book must be regarded as a primer for beginners, an outline, manual, or syllabus; and unfortunately this must narrow its range of usefulness. Perhaps its chief value would be at the student and house officer level, where it might provide orientation and perspective. It could be helpful to the young man leaving the hospital and entering practice. Comprehensive in scope, the volume includes abbreviated descriptions of almost all the disorders that affect the gastrointestinal tract, from geographic tongue to anorectal diseases. In contrast to the usual sequence, it begins with a discussion of functional syndromes so
Migratory organizing pneumonitis "primed" by radiation therapy
Authors: JY Bayle, P Nesme, F Bejui-Thivolet, R Loire, JC Guerin, JF Cordier
Journal: European Respiratory Journal (1995)

We report on two women presenting with cough and fever, 4 and 7 months, respectively, after starting breast radiation therapy following surgery for breast carcinoma. Chest roentgenogram and computed tomographic (CT) scan demonstrated alveolar opacities, initially limited to the pulmonary area next to the irradiated breast, but later migrating within both lungs. Intra-alveolar granulation tissue was found in transbronchial lung biopsies. Corticosteroid treatment resulted in dramatic clinical improvement, together with complete clearing of the pulmonary opacities on chest imaging. However, clinical and imaging relapses occurred when corticosteroids were withdrawn too rapidly; with further improvement when they were reintroduced. The reported cases clearly differ from radiation pneumonitis. They were fairly typical of cryptogenic organizing pneumonitis, also called idiopathic bronchiolitis obliterans organizing pneumonia, with the exception of the radiation therapy, partially affecting the lung, which had been performed within the previous months. Since focal radiation therapy involving the lung may induce diffuse bilateral lymphocytic alveolitis, we hypothesize that this may "prime" the lung to further injury, leading to cryptogenic organizing pneumonitis.
FDG PET-CT Demonstration of Sjogren??s Sialoadenitis
Authors: Hossein Jadvar, Shahram Bonyadlou, Andrei Iagaru, Patrick M. Colletti
Journal: Clinical Nuclear Medicine (2005)

We report the positron emission tomography-computed axial tomography (PET-CT) appearance of the inflammatory involvement of the salivary glands of a 69-year-old female with a history of lymphoma and known primary Sjogren's syndrome. Hybrid PET-CT was performed 5 months after completion of chemotherapy using a Siemens Biograph scanner (Knoxville, TN) 45 minutes after intravenous administration of 15 mCi of F-18 fluorodeoxyglucose (FDG). CT transmission scan was obtained for attenuation correction. PET-CT demonstrated no evidence of hypermetabolic nodal disease but showed symmetric intensely hypermetabolic submandibular and parotid salivary glands.
Forty Years of Medical Genetics
Authors: Victor A. McKusick
Journal: JAMA (1989)

I AM often asked why I shifted from cardiology to medical genetics; I did not. In fact my activities in the two fields developed in parallel; it was a matter of phasing out cardiology and phasing in medical genetics. Indeed, my first published piece of clinical investigation was on a genetic topic, the syndrome of spots and polyps (1949), and my first book was<i>Heritable Disorders of Connective Tissue</i>(first published in 1956). In 1952 when I completed house-staff training there was no clinical discipline of medical genetics and no formal training program. So I trained in cardiology, which brought my attention to the Marfan syndrome because of the conspicuous cardiological complications. In the early 1950s, for 5 years after completing the chief residency at Johns Hopkins in Baltimore, Md, I was a junior faculty person. I pursued the analysis of heart sounds and murmurs by a method called<i>spectral</i>
INCIDENCE OF MALIGNANCY IN PREPYLORIC ULCERS
Authors: B. R. KIRKLIN
Journal: JAMA (1942)

The incidence of malignancy in gastric ulcers near the pylorus, long assumed to be disproportionately higher than that of ulcers situated elsewhere in the stomach, has become in recent years an open question. In 1925 Orator<sup>1</sup>found in a survey of material at von Eiselsberg's clinic that 30 per cent of prepyloric ulcers were carcinomatous whereas only 2 per cent of ulcers on the lesser curvature in the median portion of the stomach were carcinomatous, and malignancy of duodenal ulcer almost never was observed. In 1929 Haudek<sup>2</sup>gave his influential endorsement to Orator's conclusions. Later one of us (B. R. K.),<sup>3</sup>who often had heard Carman comment on the frequent occurence of malignancy in prepyloric ulcers, expressed the opinion that ulcers near the pylorus are more likely to be carcinomatous than those on or near the lesser curvature well removed from the pylorus. References could be multiplied
Bullous pemphigoid arising in surgical wounds
Authors: C.K. Anderson, C.M. Mowad, M.E. Goff, M.T. Pelle
Journal: British Journal of Dermatology (2001)

Journal Article Bullous pemphigoid arising in surgical wounds Get access C.K. Anderson, C.K. Anderson Department of Dermatology, Geisinger Medical Center, 100 North Academy Avenue, Danville, PA 17822, U.S.A. *Philadelphia College of Osteopathic Medicine, Philadelphia, PA, U.S.A. Correspondence: C.M.Mowad.E‐mail: cmowad@geisinger.edu Search for other works by this author on: Oxford Academic Google Scholar C.M. Mowad, C.M. Mowad Department of Dermatology, Geisinger Medical Center, 100 North Academy Avenue, Danville, PA 17822, U.S.A. *Philadelphia College of Osteopathic Medicine, Philadelphia, PA, U.S.A. Correspondence: C.M.Mowad.E‐mail: cmowad@geisinger.edu Search for other works by this author on: Oxford Academic Google Scholar M.E. Goff, M.E. Goff Department of Dermatology, Geisinger Medical Center, 100 North Academy Avenue, Danville, PA 17822, U.S.A. *Philadelphia College of Osteopathic Medicine, Philadelphia, PA, U.S.A. Correspondence: C.M.Mowad.E‐mail: cmowad@geisinger.edu Search for other works by this author on: Oxford Academic Google Scholar M.T. Pelle M.T. Pelle Department of Dermatology, Geisinger Medical Center, 100 North Academy Avenue, Danville, PA 17822, U.S.A. *Philadelphia College of Osteopathic Medicine, Philadelphia, PA, U.S.A. Correspondence: C.M.Mowad.E‐mail: cmowad@geisinger.edu Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 145, Issue 4, 1 October 2001, Pages 670–672, https://doi.org/10.1046/j.1365-2133.2001.04427.x Published: 01 October 2001
China's ratio of male to female babies remains high despite sixth annual fall
Authors: S. Dai, X. Li
Journal: BMJ (2015)

China recorded 115.88 boys born for every 100 girls in 2014, data from the National Health and Family Planning Commission have shown. This is the sixth year in a row that the ratio has fallen since 2009, when it stood at 119.45.

However, experts regard China’s sex ratio at birth as still too high and say that it is having an unhealthy effect on society. Large numbers of young men, especially in rural areas, are unable …
Improved visualization of aortopulmonary collateral arteries by abdominal aortic compression during angiography.
Authors: J N Moll, M A Santos, C Drumond, N Romao, M Murad, N B Reis
Journal: Circulation (1982)

Increased filling of aortopulmonary collateral arteries occurs when the descending aorta is obstructed distal to their origin. We used this fact to develop a simple, safe technique for improving angiographic visualization of these arteries. The abdominal aorta is manually compressed against the spine during injection of contrast medium. A slight reflex bradycardia resulted, which probably also enhanced filling of the collateral arteries. In eight infants and children with either pulmonary atresia and a ventricular septal defect or truncus arteriosus communis, excellent visualization was consistently achieved without complication.
Abstract 3117: BET bromodomain inhibition triggers apoptosis of NF1-associated malignant peripheral nerve sheath tumors through Bim induction
Authors: Amish J. Patel, Chung-Ping Liao, Zhiguo Chen, Chiachi Liu, Yong Wang, Lu Q. Le
Journal: Cancer Research (2014)

Abstract Malignant Peripheral Nerve Sheath Tumors (MPNSTs) are highly aggressive sarcomas that develop sporadically or in Neurofibromatosis type 1 (NF1) patients. MPNSTs are typically fatal, and effective treatments remain limited. To gain insights into MPNST pathogenesis, we utilized a novel MPNST mouse model that allowed us to study the evolution of these tumors at the transcriptome level. Strikingly, in MPNSTs we found upregulation of chromatin regulator Brd4, and show that BRD4 inhibition profoundly suppresses both growth and tumorigenesis. Our findings reveal new roles for BET bromodomains in MPNST development, and report a novel mechanism by which bromodomain inhibition induces apoptosis through induction of pro-apoptotic Bim, which may represent a paradigm shift in therapy for MPNST patients. Moreover, these findings indicate novel epigenetic mechanisms underlying the balance of anti-/pro-apoptotic molecules, and suggest that bromodomain inhibition can shift this balance in favor of cancer cell apoptosis. Citation Format: Amish J. Patel, Chung-Ping Liao, Zhiguo Chen, Chiachi Liu, Yong Wang, Lu Q. Le. BET bromodomain inhibition triggers apoptosis of NF1-associated malignant peripheral nerve sheath tumors through Bim induction. [abstract]. In: Proceedings of the 105th Annual Meeting of the American Association for Cancer Research; 2014 Apr 5-9; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2014;74(19 Suppl):Abstract nr 3117. doi:10.1158/1538-7445.AM2014-3117
Late phase of nitroglycerin-induced coronary vasodilatation blunted by inhibition of prostaglandin synthesis.
Authors: B Trimarco, A Cuocolo, D Van Dorne, B Ricciardelli, M Volpe, A De Simone, M Condorelli
Journal: Circulation (1985)

In chloralose-anesthetized dogs with the left circumflex coronary artery perfused at constant flow, the effects of increasing doses of indomethacin or naproxen on the coronary and systemic hemodynamic responses to a 5 microgram intracoronary injection of nitroglycerin (NTG) were evaluated. The integrated areas of NTG-induced coronary vasodilatation were reduced after administration of indomethacin or naproxen. The extent of this reduction was increased progressively by augmenting the dose of indomethacin and naproxen up to 1.5 and 7 mg/kg, respectively. We also assessed the extent of cyclooxygenase inhibition induced by indomethacin or naproxen through the radioimmunoassay of thromboxane B2, which reflects thrombin-induced activation of platelet thromboxane A2 production during whole blood clotting. The level of inhibition progressively increased and complete inhibition was attained with 1.5 mg/kg indomethacin and 7 mg/kg naproxen. Further increase in dosage failed to induce further reduction of integrated areas of coronary vasodilatation, and a correlation was found between the extent of the reduction of the integrated areas of coronary vasodilatation and the dose of indomethacin (r = .828, n = 35, p less than .001) or naproxen (r = .729, n = 35, p less than .001). Finally, the NTG-induced maximum fall in coronary perfusion pressure remained unmodified after inhibition of prostaglandin synthesis, but there was a faster return of the perfusion pressure to the basal value.(ABSTRACT TRUNCATED AT 250 WORDS)
RAPID EXTRACTION OF GRASS POLLEN ALLERGENS AND SEPARATION OF THEIR ACTIVE FRACTIONS
Authors: H. MORROW BROWN &, NAZRA THANTREY
Journal: Allergy (1976)

The immediate effects of nasal provocation tests with dry grass pollen, correlated with recent botanical evidence of almost instant release of allergens from the pollen wall, suggested that prolonged extraction of pollens was unnecessary and perhaps undesirable. It has now been shown that all the active allergens from undefatted dry grass pollens of the 12 major British species are extracted completely in 15 min. Gel chromatography of such rapid extracts has shown clear-cut separation of active from inactive material, as confirmed by skin and nasal provocation testing. It is probable that active fractions thus obtained contain the only pollen allergens of importance to clinical allergy. Further purification may produce specific allergens useful for the accurate standardisation of vaccines.
Cost Sharing as a Tool to Drive Higher-Value Care
Authors: Katherine Baicker, Helen Levy
Journal: JAMA Internal Medicine (2015)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Internal Medicine HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Internal Medicine journal
Ninth Fishbein Fellow Begins Program
Authors: Chris Anne Raymond
Journal: JAMA (1986)

<b>JODY W. ZYLKE</b>, MD, is<i>JAMA</i>'s ninth Morris Fishbein Fellow in Medical Journalism. Zylke, a native of Milwaukee who began her fellowship this month, has had varied clinical experience. At Harvard Medical School, Boston, she conducted a clinical research project in adolescent medicine. After graduation in 1981, she finished an internship and residency in pediatrics at the University of California, Los Angeles, Hospital. She then spent a year as staff pediatrician and pediatric supervisor at the San Fernando (Calif) Public Health Clinic. Prior to coming to<i>JAMA</i>, she was in private practice with the Child Life Center of Tinley Park and Homewood, Ill, and Munster, Ind, as well as serving as a clinical instructor at Wyler Children's Hospital at the University of Chicago. In addition to her practice, Zylke has written two chapters and served as a medical consultant for the pediatric section of<i>The New Complete Baby Book</i>
An Unusual Case of Polypoid Angiodysplasia
Authors: N. Kakushima, M. Fujishiro, N. Yahagi, M. Oka, K. Kobayashi, T. Hashimoto, H. Miyoshi, Y. Moriyama, S. Enomoto, M. Iguchi, M. Ichinose, M. Omata
Journal: Endoscopy (2004)

Figure 1 A healthy 59-year-old man underwent colonoscopy because of a positive fecal blood test. A yellowish-white lobulated polyp, 15-mm in size with a "baby's hand"-like morphology, was seen. Endoscopic polypectomy for suspected leiomyoma was performed without complication.
Anti‐Pr cold hemagglutination associated with livedo reticularis
Authors: Virgil L. Rose, Hau C. Kwaan
Journal: American Journal of Hematology (1985)

Abstract A report of anti‐Pr cold hemagglutination associated with livedo reticularis is presented. Livedo reticularis is descriptive of the superficial venous system appearing when blood flow is altered in this area. Cold antibody directed against the Pr antigen of the red cell membrane can cause hemagglutination, thereby altering blood flow in cooler areas of the body. This patient had livedo reticularis approximately 8 months prior to detection of the anti‐Pr cold agglutinin.
Treatment of Hydrophobia in the Last Century: Method of Treating Those That Have Been under My Care for the Bite of a Mad Dog, or Other Mad Animal
Authors: J. Dyer
Journal: BMJ (1848)

texture of the heart has been weakened by carditis or endocarditis, appears evident from the details of a case, in which indammatory exudation on the lining mem- brane of this organ co-existed with inflammatory softening of its whole structure at the apex, and in which, at this point, a considerable degree of attenu- ation had taken place, which might no doubt, after some time, have gone on to rupture.-Ibid.6. Perforating Ulcer of the Stomach.-Of the patients labouring under this disease, noticed by Jaksch, thirty- three had acute tubercle of the lungs, twenty-six ehronic tubercle of the lungs, and forty-three pneu- monia.He therefore presumes that some relation exists between the affection in question and diseases of the lung.The same physician gives the following sketch of the symptoms commonly observed with this kind of ulceration.After intense mental or bodilv exertion, or the use of some stimulating liquor or article of food, the patient complains of violent pain, extend- ing upwards from the pit of the stomach, which often disappears after vomiting.The tongue still remains clean, the appetite is variouslv altered, and the bowels are for the most part obstinately costive.Sometimes the symptoms assume more of the character of those which accompany mucous gastritis.There is a dull persistent pain in the epigastrium, pyrosis, indigestion, vomiting, and tumefaction of the abdomen.Jak-sch, in speaking of the treatment of these cases, recom- mends the use of milk, veal soup, and chicken soup, as articles of diet.He also recommends, as palliative remedies, leeching and counter-irritation of the epigas- tric region, anodynes, the acetate of lead, and iron.-Ibid.