tbuckley/cabot-search huggingface dataset:
THE PLACE OF HEBOSTEOTOMY AS AN AID TO DELIVERY
Authors: CHANNING W. BARRETT
Journal: JAMA (1910)

Since pregnancy in woman usually consists in single fetation and since the child is born needing the care of the mother for years to come, that obstetric treatment which does not strive to the utmost to result in a living healthy mother and child ignores the fundamental purpose of pregnancy, namely, reproduction. The obstetric art cannot afford to be wasteful of a single life. As long as there is a child mortality of 2 per cent., as reported by Hill, as well as a maternal mortality and morbidity and due directly or indirectly to disproportion between the size of the passage and the passenger, we are entirely justified in our efforts to secure for each mother and child that treatment best adapted to their needs. <h3>APPLICATION AND LIMITATION OF HEBOSTEOTOMY</h3> Hebosteotomy must be considered in the light of its success in certain conditions in which other measures fail and its
Ectopic bone formation associated with mesenchymal stem cells in a resorbable calcium deficient hydroxyapatite carrier
Authors: Philip Kasten, Julia Vogel, Reto Luginbühl, Philip Niemeyer, Marcus Tonak, Helga Lorenz, Lars Helbig, Stefan Weiss, Jörg Fellenberg, Albrecht Leo, Hans-Georg Simank, Wiltrud Richter
Journal: Biomaterials (2005)
1020-4 Proximal Isovelocity Surface Area Method Applied to Non-Planar Surfaces: Implications of In Vitro Studies for Clinical Regurgitation and Stenosis
Authors: Shinsuke Tsuji, Mei-Yu Chuang, Edward G. Cape, Keong Joung, Cheryl L. Reid, Julius M. Gardin
Journal: Journal of the American College of Cardiology (1995)
C-type natriuretic peptide, a novel antifibrotic and antihypertrophic agent, prevents cardiac remodeling after myocardial infarction
Authors: Takeshi Soeki, Ichiro Kishimoto, Hiroyuki Okumura, Takeshi Tokudome, Takeshi Horio, Kenji Mori, Kenji Kangawa
Journal: Journal of the American College of Cardiology (2005)
Growth Hormone Replacement Decreases Plasma Levels of Matrix Metalloproteinases (2 and 9) and Vascular Endothelial Growth Factor in Growth Hormone–Deficient Individuals
Authors: Harpal S. Randeva, Krzysztof C. Lewandowski, Jan Komorowski, Robert D. Murray, Chris J. O’Callaghan, Edward W. Hillhouse, Henryk Stepien, Stephen M. Shalet
Journal: Circulation (2004)

Background— Matrix metalloproteinases (MMP) are implicated in cardiovascular disease. Growth hormone (GH) deficiency is associated with increased cardiovascular mortality. We assessed whether GH replacement, in GH-deficient adults, has any effect on plasma levels of MMP-2 and MMP-9 and on vascular endothelial growth factor (VEGF), known to activate MMPs. Methods and Results— The study comprised 66 GH-deficient adults, 37.8±14.7 years of age (37 female). Plasma MMP-2 and MMP-9, VEGF, and insulin-like growth factor-1 (IGF-1) were measured at baseline (V 1 ), at 12 months (V 2 ), and at 24 months of GH treatment (V 3 ). IGF-1 levels rose under GH replacement (mean±SD): V 1 , 151.6±91.9 μg/mL; V 2 , 270.2±114.8 μg/mL; and V 3 , 266.2±109.8 (V 1 versus V 2 ; P &lt;0.001: V 2 versus V 3 ; P =0.76). MMP-9 exhibited the most pronounced and sustained decline from 1248.0±651.1 ng/mL at V 1 , 949.2±457.7 ng/mL at V 2 , and 760.8±386.1 ng/mL at V 3 ( P &lt;0.001 at all time points). A similar pattern was detected for VEGF levels: 358.5±209.0 pg/mL at V 1 , 310.6±225.7 pg/mL at V 2 ( P &lt;0.001), and 283.7±202.7 pg/mL at V 3 (V 2 versus V 3 ; P =0.005). MMP-2 demonstrated a significant decline initially from V 1 to V 2 (1134.4±217.8 ng/mL versus 1074.5±203.0 ng/mL, respectively; P =0.031), reaching a plateau at V 3 (1072.3±220.2 ng/mL) (V 2 versus V 3 ; P =0.93). A negative relation existed between MMP-9 versus IGF-1 and MMP-2 versus IGF-1 ( P &lt;0.001 and P =0.007, respectively) as well as between VEGF and IGF-1 ( P &lt;0.001). Conclusions— These changes in MMPs and VEGF may contribute to the anticipated reduction in vascular mortality in hypopituitary adults receiving GH replacement.
Sinusitis of the Maxillary Antrum
Authors: Frank O. Evans, J. Brantley Sydnor, W. E. C. Moore, George R. Moore, J. Laurence Manwaring, Alan H. Brill, Robert T. Jackson, Stevan Hanna, Joy S. Skaar, Lillian V. Holdeman, G. Slaughter Fitz-Hugh, Merle A. Sande, Jack M. Gwaltney
Journal: New England Journal of Medicine (1975)

Twenty-four adults with clinical evidence of sinusitis were studied by 65 needle punctures of the maxillary antrum. Fourteen of 15 sinuses with normal transillumination and 19 of 26 that were dull had normal aspirates, whereas 24 of 24 that were opaque had abnormal aspirates (P < 0.001). Marked mucosal thickening as determined radiologically (Water's view) was associated with abnormal aspirates whereas lesser mucosal thickening was not(P < 0.001). In acute sinusitis, there was a strong correlation between high aspirate leukocyte counts (> 1000 per cubic millimeter) and infection as manifested by bacterial titers of > 105 per milliliter or the isolation of a virus or fungus (P < 0.001). Anterior-nasal-swab cultures correlated poorly with direct aspirate cultures. Organisms frequently recovered from the sinus included Haemophilus influenzae, Streptococcus pneumoniae, and anaerobic bacteria. Rhinovirus was recovered twice. Antibiotics were useful in patients with acute sinusitis if the organism was sensitive in vitro (P < 0.001 ). (N Engl J Med 293:735–739,1975)
The Endocannabinoid Anandamide Protects Neurons during CNS Inflammation by Induction of MKP-1 in Microglial Cells
Authors: Eva Eljaschewitsch, Anke Witting, Christian Mawrin, Thomas Lee, Peter M. Schmidt, Susanne Wolf, Heide Hoertnagl, Cedric S. Raine, Regine Schneider-Stock, Robert Nitsch, Oliver Ullrich
Journal: Neuron (2006)
RBC Zinc Protoporphyrin to Screen Blood Donors for Iron Deficiency Anemia
Authors: Ron B. Schifman, Shirley L. Rivers, Paul R. Finley, Cole Thies
Journal: JAMA (1982)

We evaluated a rapid RBC zinc protoporphyrin (ZP) test in 1,147 male and 615 female blood donors to study its value in screening for evolving iron deficiency anemia. Fifteen men (1.8%) and 32 women (7.9%) who returned to donate were found to be anemic. A matched sample analysis between anemic and nonanemic donors demonstrated significant differences in serum ferritin levels, percent iron saturation, and the RBC ZP level from samples collected during the initial evaluation. Red cell ZP correlated well with the natural logarithm of serum ferritin in both men and women who later became anemic. The predictive value of RBC ZP levels compared favorably with that of the serum ferritin level. We also observed a strong association between the yearly donation frequency and RBC ZP concentration. These findings indicate that predonation RBC ZP testing may be useful in screening for iron depletion and potential risk of anemia in blood donors. (<i>JAMA</i>1982;248:2012-2015)
“PIKing” the Winner for Phosphatidylinositol 3-Kinase Inhibitors in ErbB2-Positive Breast Cancer: Let's Not “PTENed” It's Easy!
Authors: Matthew J. Ellis, Robert Crowder
Journal: Clinical Cancer Research (2007)

ErbB2 targeting with the monoclonal antibody trastuzumab and, more recently, with the small-molecule inhibitor lapatinib have made significant inroads into the mortality and morbidly associated with ErbB2-positive breast cancer. However, these agents are only partially effective and resistance
Cancer's Next Frontier
Authors: Elena B. Elkin, Peter B. Bach
Journal: JAMA (2010)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Increased expression of tenascin in the dermis in scleroderma
Authors: J.P. LACOUR, A. VITETTA, R. CHIQUET-EHRISMANN, A. PISANI, J.P. ORTONNE
Journal: British Journal of Dermatology (1992)

The expression of tenascin, a recently discovered extracellular matrix protein, was studied by immunohistochemical techniques in scleroderma skin and compared with its distribution in normal skin. In progressive systemic sclerosis, a marked increase in tenascin content was observed in the superficial reticular dermis. In localized scleroderma, the deposition of tenascin was increased both in the superficial and deep dermis of involved skin, whereas in clinically uninvolved skin the distribution of tenascin was the same as in normal control skin, i.e. the papillary dermis and periappendageal zone. The distribution of tenascin did not strictly parallel that of fibronectin. These findings and the current knowledge of tenascin biology suggest that the overproduction of tenascin in scleroderma dermis could be secondary to stimulation of fibroblasts by immune cell‐derived cytokines, or could be due to abnormal fibroblasts, or a subpopulation of fibroblasts, producing high levels of this extracellular matrix protein.
Algorithms for Assessing Cardiovascular Risk in Women
Authors: Michael J. Pencina, Ramachandran S. Vasan, Ralph B. D’Agostino
Journal: JAMA (2007)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
A ubiquitin-based assay for the cytosolic uptake of protein transduction domains
Authors: Fabien Loison, Philippe Nizard, Tony Sourisseau, Pascale Le Goff, Laure Debure, Yves Le Drean, Denis Michel
Journal: Molecular Therapy (2004)

Protein transduction domains (PTDs) are promising tools for transducing presynthesized polypeptides across the plasma membrane. However, the development and optimization of PTDs are hampered by many technical problems and artifacts resulting notably from the tight binding of PTDs to the cell surface and the difficulty in discriminating, through imagery analyses, truly cytosolic from cytoplasmic vesicular compartments. To circumvent these problems, we have developed an unambiguous enzymatic assay of the cytosolic uptake of PTD-driven proteins, based on the processing by ubiquitin-specific C-terminal proteases (DUBs). This method, coupled with fluorometry and fluorescence microscopy, shows that the TAT PTD derived from human immunodeficiency virus type 1 is rapidly taken up by cells but fails to reach their cytosol, except when dendritic cells, which are known to take up circulating antigens for cross-presentation, are used. In addition to its usefulness in assessing cytosolic uptake, DUB processing of PTD-linked proteins can ensure the intracellular release of cargo proteins, which might prove helpful for MHC-I-based vaccination or intracellular delivery of biologically active polypeptides.
Press: Alcohol: the media are in denial
Authors: C. Brewer
Journal: BMJ (2001)

<h3></h3> Functional Neurological Symptom Disorder (FNSD) and Autistic Spectrum Disorders (ASD) are both complex and incompletely understood conditions. This review investigates the literature for evidence of associa- tion between them. A literature search produced nine <b>Results</b> three case reports and six epidemiological studies. The case reports describe the conditions co-occurring, providing anecdotal evidence of an association. Nimmo- Smith and Lever reported 2.5-fold and three-fold higher prevalence of ‘somatoform disorders’ in ASD samples compared to the general population (Lever 2016; Nimmo-Smith 2020). Jester and Schendel published studies which both suggest higher rates of functional symptoms in ASD patients, are limited by methodological issues (Jester 2016; Schendel 2019). Only the study by Roy reported no difference; 8% prevalence compared to 7.5% (Roy 2015). McWilliams et al reported a case series showing a much higher rate of ASDs in 59 young people with non-epileptic seizures; 16.9%, compared to 1.3–1.5% in the general population (McWilliam 2019). The range of terminology and methodology used makes integrating the results difficult, but overall there is evidence of an association between ASD and FNSD. Potential mechanisms linking the two such as emotional dysregulation and alexithymia are highlighted, as well as brain regions including the amygdala and anterior cingulate cortex (ACC). jacob.john.roelofs@gmail.com
Effect of Number of Lymph Nodes Sampled on Outcome in Patients With Stage I Non–Small-Cell Lung Cancer
Authors: Ajeet Gajra, Nancy Newman, Gary P. Gamble, Leslie J. Kohman, Stephen L. Graziano
Journal: Journal of Clinical Oncology (2003)

Purpose: We postulate that surgical sampling and pathologic evaluation of lymph nodes of surgical specimens from patients with stage I non–small-cell lung cancer (NSCLC) can have an effect on the time to recurrence and survival of these patients. Patients and Methods: We analyzed data on 442 patients with stage I NSCLC who were treated with surgical resection and some form of lymph node sampling. Associations between total lymph nodes sampled and disease-free survival (DFS) and overall survival (OS) were investigated. The effect of total lymph node stations sampled and the surgical techniques (random lymph node sampling, systematic sampling [SS], or complete mediastinal lymph node dissection [MLND]) on DFS and OS was also studied. Complete MLND and SS were defined as dissection or sampling of levels 4, 7, and 10 for right-sided lesions and levels 5 or 6 and 7 for left-sided lesions. Results: Patients were divided into quartiles on the basis of total number of lymph nodes sampled. Improved DFS and OS were associated with greater number of lymph nodes sampled. SS and MLND were associated with improved survival compared with random lymph node sampling. The total number of lymph nodes sampled maintained strong significance in the multivariate analysis. Conclusion: These results indicate that examining a greater number of lymph nodes in patients with stage I NSCLC treated with resection increases the likelihood of proper staging and affects patient outcome. Such information is important not only for therapy and prognosis of individuals but also for identifying those who may benefit from adjuvant therapy.
Liver transplantation normalizes serum hepcidin level and cures iron metabolism alterations in<i>HFE</i>hemochromatosis
Authors: Edouard Bardou-Jacquet, Julie Philip, Richard Lorho, Martine Ropert, Marianne Latournerie, Pauline Houssel-Debry, Dominique Guyader, Olivier Loréal, Karim Boudjema, Pierre Brissot
Journal: Hepatology (2013)

Defects in human hemochromatosis protein (HFE) cause iron overload due to reduced hepatic hepcidin secretion. Liver transplantation (LT) is a key treatment for potential complications from HFE-related hereditary hemochromatosis (HH). This study evaluated hepcidin secretion and iron burden after LT to elucidate HH pathophysiology. Patients (n = 18) homozygous for the p.Cys282Tyr mutation in the HFE gene underwent LT between 1999 and 2008. Serum iron, serum hepcidin, and hepatic iron concentrations were determined before LT and at the end of follow-up (median 57 months). Mortality and causes of death were determined. Survival was compared to that of the overall patient population that received LT. Before LT, serum hepcidin levels were low (0.54 ± 2.5 nmol/L; normal range: 4-30 nmol/L). After LT, 11 patients had iron evaluations; none received iron depletion therapy; all had normal transferrin saturation. The mean serum ferritin was 185 (±99) μg/L. Magnetic resonance imaging showed that iron overload was absent in nine patients, mild in one patient with metabolic syndrome, and high (180 μmol/g) in one patient with hereditary spherocytosis discovered after LT. At the end of follow-up, serum hepcidin was normal in 10 patients (11.12 ± 7.6 nmol/L; P &lt; 0.05) and low in one patient with iron deficiency anemia. Survival was 83% and 67% at 1 and 5 years, respectively. Survival was similar for patients with HH and patients that received LT for other causes. Conclusion : In HH, LT normalized hepcidin secretion and prevented recurrence of hepatic iron overload. Survival was similar to that of patients who received LTs for other liver diseases. (HEPATOLOGY 2014;59:839–847)
The effects of transcutaneous electrical nerve stimulation in patients with severe angina pectoris.
Authors: C Mannheimer, C A Carlsson, H Emanuelsson, A Vedin, F Waagstein, C Wilhelmsson
Journal: Circulation (1985)

The pain-relieving effects of transcutaneous electrical nerve stimulation (TENS) were investigated in patients with severe angina pectoris first with respect to systemic and coronary hemodynamics and myocardial metabolism during pacing-induced angina and second in a controlled long-term study. Two series of patients with severe angina pectoris (NYHA class III to IV) were studied (13 patients in the pacing study and 23 in the long-term study). In the pacing-induced angina study there was increased tolerance to pacing (142 +/- 23 compared with 124 +/- 20 beats/min tolerated, p less than .001), improved lactate metabolism (2 +/- 36% compared with -18 +/- 43%, p less than .01), and less pronounced ST segment depression (2.3 +/- 1.1 compared with 2.9 +/- 2.6 mm, p less than 0.05) with TENS. In the long study the effects of TENS were measured by means of repeated bicycle ergometer test, frequency of anginal attacks, and consumption of short-acting nitroglycerin. TENS was used regularly for 1 hr three times per day. The TENS treatment group had increased work capacity (637 +/- 308 vs 555 +/- 277 W . min, p greater than .001), decreased ST segment depression (2.3 +/- 1.1 vs 3.6 +/- 1.6 mm, p less than .001), reduced frequency of anginal attacks (p less than .05), and reduced consumption of short-acting nitroglycerin per week (p less than .05) compared with the control group. The observed effects were mainly due to decreased afterload resulting from systemic vascular dilatation.
C Terminus of <i>Clostridium perfringens</i> Enterotoxin Downregulates CLDN4 and Sensitizes Ovarian Cancer Cells to Taxol and Carboplatin
Authors: Zhijian Gao, Xiaoyin Xu, Bruce McClane, Qing Zeng, Babak Litkouhi, William R. Welch, Ross S. Berkowitz, Samuel C. Mok, Elizabeth I.O. Garner
Journal: Clinical Cancer Research (2010)

We have previously shown that CLDN4 (encoding claudin-4), a cell tight junction (TJ) protein, is highly expressed in human epithelial ovarian carcinomas (EOC) but undetectable in normal ovaries. CLDN4 has been identified as a specific receptor for C terminus of Clostridium perfringens enterotoxin (C-CPE), a nontoxic molecule that may disrupt TJ barrier function and enhance cellular absorption. The purpose of this study was to determine the potential clinical applications of C-CPE and its effects on CLDN4 expression in EOC.Using a 3-dimensional culture model and monolayer culture of EOC cells, we examined the effects of C-CPE on CLDN4 expression by quantitative real-time PCR, immunofluorescence, and Western blot. The synergistic effect of C-CPE to clinically relevant chemotherapies (Taxol and Carboplatin) was observed in EOC culture and xenograft mice. Furthermore, we determined through oligonucleotide microarray analysis that the transcript profile alterations dysregulated as a consequence of C-CPE treatment.C-CPE treatment decreased protein expression and relocated CLDN4 from cell-cell contact regions to the cytoplasm. Particularly, C-CPE sensitized EOC cells to chemotherapeutic administration at low dosages and significantly inhibited tumor growth in a nontoxic manner. Furthermore, we provided genome-wide molecular evidence that C-CPE treatment is involved in the stimulation of the ubiquitin-proteasome pathway and the inhibition of cell metabolism in EOC cells.The addition of C-CPE can enhance the effectiveness of Taxol or Carboplatin and significantly inhibited EOC cell growth in a CLDN4-dependent manner, suggesting that C-CPE may have promising therapeutic potential for EOC.
Activation of cAMP–PKA signaling in vivo inhibits smooth muscle cell proliferation induced by vascular injury
Authors: Ciro Indolfi, Enrico Vittorio Avvedimento, Emilio Di Lorenzo, Giovanni Esposito, Antonio Rapacciuolo, Paola Giuliano, Domenico Grieco, Luigi Cavuto, Angela M. Stingone, Ilaria Ciullo, Gianluigi Condorelli, Massimo Chiariello
Journal: Nature Medicine (1997)
Genetic control of cutaneous basophil hypersensitivity.
Authors: M Stadecker, S Leskowitz
Journal: The Journal of Experimental Medicine (1976)

CBH to DNP-GL could be elicited only in responder guinea pigs which possess the genetic ability to develop classic delayed type hypersensitivity to DNP-PLL, the response to which is governed by the same gene. Since the defect in nonresponder animals seems to reside at the level of their T cells and not B cells, these results lend support to the contention that CBH, as well as DH, is dependent on and probably mediated by T cells.