tbuckley/cabot-search huggingface dataset:
Combination intensive DMARD therapy is noninferior to TNF inhibitors for reducing disability in active RA
Authors: B.D. McLeod
Journal: Annals of Internal Medicine (2015)

Source Citation Scott DL, Ibrahim F, Farewell V, et al. Tumour necrosis factor inhibitors versus combination intensive therapy with conventional disease modifying anti-rheumatic drugs in established rheumatoid arthritis: TACIT non-inferiority randomised controlled trial. BMJ. 2015;350:h1046. 25769495
Abstract 13267: Age-Related Long-Term Benefit of Cardiac Resynchronization Therapy in LBBB Patients - a MADIT-CRT Long-Term Follow-Up Substudy
Authors: Sabu Thomas, Arthur J Moss, Wojciech Zareba, Scott McNitt, Alon Barsheshet, Helmut Klein, Illan Goldenberg, David T Huang, Valentina Kutyifa
Journal: Circulation (2014)

Background: Among patients with heart failure (HF), cardiac resynchronization therapy (CRT) combined with a defibrillator (CRT-D) reduces HF events and mortality compared with a defibrillator (ICD) alone. Whether these benefits extend to all age-groups during long-term follow-up is unclear. Hypothesis: We hypothesized that CRT-D would benefit all age groups with respect to reductions in HF events and all-cause mortality. Methods: We assessed the effect of age on HF events and death among patients in the MADIT-CRT long-term follow up study. 1281 patients with class I or II heart failure and left-bundle branch block (LBBB) were randomized to CRT-D or ICD alone. Patients were divided into 3 age groups: &lt;60, 60-74 or ≥75 years and evaluated over 7 years for mortality and HF events. We compared cumulative events using the log-rank test and adjustments were made using a multivariate logistic regression model with various pre-specified covariates. Results: Overall 761 patients received CRT-D and 520 received ICD alone. The median age was 65 years. Among the three age groups, &lt;60, 60-74 and ≥75 there were 399, 651 and 231 patients respectively. Multivariate analysis (Table) revealed that CRT-D compared to ICD alone significantly reduced the composite outcome of HF or death across all age groups: &lt;60 years relative risk reduction (RRR)=39%, p=0.0236; 60-74 years RRR=59%, p&lt;0.001; ≥75 years RRR=55%, p&lt;0.001. CRT-D also significantly reduced HF events in all age groups &lt;60 years RRR=52%, p=0.003; 60-74 years RRR=61%, p&lt;0.001; ≥75 years RRR=73%, p&lt;0.001. CRT-D was associated with significant mortality reduction only in the 60-74 year age group RRR 58%, p&lt;0.001. Conclusion: Among patients with asymptomatic or mild heart failure, reduced LVEF and LBBB, CRT-D results in significant reduction of HF events and in the composite of all-cause mortality and HF events during long-term follow-up. All-cause mortality was significantly reduced with CRT-D only in the 60-74 year age group.
Self‐Immolative Linkers Literally Bridge Disulfide Chemistry and the Realm of Thiol‐Free Drugs
Authors: Camilla Frich Riber, Anton A. A. Smith, Alexander N. Zelikin
Journal: Advanced Healthcare Materials (2015)

The ultimate goal of controlled, intracellulardrug delivery is to get the drug to the target cell without spilling the contents in transit and then release the entire payload upon cell entry. One of the most powerful platforms to achieve this relies on the intracellular disulfide reshuffling as a trigger for drug release form the engineered prodrugs. However, utility of disulfide reshuffling for drug release is naturally applicable only to the thiol containing molecules-ultimately leaving nearly all commercialized drugs beyond the scope of this platform. This is a drastic limitation. A cunning new tool of organic chemistry is fast entering the mainstream of prodrug design: the self-immolative linkers. This platform allows overcoming the natural chemical barrier and makes it possible to link virtually any drug to its carrier via a disulfide bond and engineer a specific intracellular release. It is a game-changing accomplishment of modern organic chemistry. The scope and limitations of this novel opportunity for medicinal chemistry and nanomedicine are outlined.
Sustained effect of SQ‐standardized grass allergy immunotherapy tablet on rhinoconjunctivitis quality of life
Authors: L. Frølund, S. R. Durham, M. Calderon, W. Emminger, J. S. Andersen, P. Rask, R. Dahl
Journal: Allergy (2009)

The prevalence of allergic rhinoconjunctivitis has increased significantly over the past decades with grass pollen being a common trigger. The impact of allergy on patient's quality of life is substantial.To investigate the sustained effect on quality of life during the grass pollen season 1 year after 3 years of treatment with the SQ-standardized grass allergy immunotherapy tablet (AIT), Graza (Phleum pratense 75,000 SQ-T/2800 BAU; ALK, Denmark).The trial was a randomized, parallel-group, double-blind, placebo-controlled trial in adult subjects with a history of moderate-severe grass pollen induced rhinoconjunctivitis inadequately controlled by symptomatic medications. Subjects received 3 years of grass AIT (n = 157) or placebo (n = 126), followed by 1 year of follow-up. Quality of life assessments were based on the standardized rhinoconjunctivitis quality of life questionnaire (RQLQ(S)); completed weekly during the entire grass pollen season.During follow-up, the overall RQLQ(S) score for the entire grass pollen season was significantly improved in the active group (relative difference to placebo: 23%, P = 0.004). The improvement was higher during the peak pollen season (28%, P = 0.001). The treatment effect of grass AIT during the follow-up year and the previous three treatment years was similar. Improvements were found in all seven RQLQ(S) domains. The RQLQ(S) as a function of the weekly average pollen counts showed a clear separation between the treatment groups (P < 0.001).In subjects inadequately controlled by symptomatic medications, grass AIT provided sustained and clinically relevant improvements in rhinoconjunctivitis quality of life compared to placebo. The effect increased with increasing grass pollen exposure.
Abstract 9501: Gender Differences in Mortality Associated with Implantable Cardioverter-Defibrillator Infections
Authors: Muhammad RSohail, Charles AHenrikson, Mary JoBraid-Forbes, KevinForbes, Daniel JLerner
Journal: Circulation (2012)

Introduction: Implantable cardioverter-defibrillators (ICDs) reduce morbidity and mortality in appropriately selected patients, but device-related infections are associated with significant mortality that can mitigate this benefit. Women are at higher risk for adverse events during ICD procedure admissions, but there are limited data on the mortality associated ICD infection in women. Objective: To compare the clinical characteristics and mortality rate of men and women who have an infection associated with ICD procedure. Methods: Retrospective cohort study of 64,903 Medicare fee-for-service patients admitted for ICD generator implantation, replacement, or revision from January 1, 2007 to December 31, 2007. Primary outcome measures were unadjusted and risk-adjusted longer-term mortality associated with ICD infection. Results: There were a total of 1,855 (2.89%) admissions with an ICD infection. Longer-term mortality (death during admission quarter and subsequent 4 quarters) was significantly higher with I...
Screening the allergenic repertoires of wheat and maize with sera from double‐blind, placebo‐controlled food challenge positive patients
Authors: M. Weichel, N. J. Vergoossen, S. Bonomi, J. Scibilia, C. Ortolani, B. K. Ballmer‐Weber, E. A. Pastorello, R. Crameri
Journal: Allergy (2005)

Background: Food allergy to wheat and maize is an increasing factor of deterioration of life quality, especially childhood and can, in rare cases, even induce anaphylaxis. Although omega‐5 gliadin from wheat and maize lipid transfer protein have been characterized as major cereal allergens on the molecular level, the list of food allergens is far to be complete. Methods: To identify the IgE‐binding repertoires of wheat and maize we screened respective cDNA libraries displayed on phage surface with sera from patients with a confirmed food allergy. The study included six patients with a positive double‐blind, placebo‐controlled food challenge (DBPCFC) to wheat, nine patients with a positive DBPCFC to maize, and six patients with anaphylactic reactions after ingestion of wheat. Results: The enriched sequences encoding IgE‐binding proteins showed heterogeneous repertoires for both, wheat and maize. The selected wheat repertoire yielded 12, the maize repertoire 11 open reading frames. Among these we identified allergens belonging to already characterized allergens families, such as gliadin, profilin and beta‐expansin. Besides, we found novel proteins with high cross‐reactive potential, such as thioredoxins, as well as sequences that had so far not been related to cereal allergy at all. The IgE‐binding capacity of some selected proteins was evaluated in vitro and cross‐reactivity was demonstrated by competition ELISA. Conclusion: With regard to the heterogeneity of the characterized sequences as well as to the biochemical nature of the new allergens detected we conclude that wheat and maize‐related food allergy is more complex than so far anticipated.
Modern Ophthalmology; A Practical Treatise on the Anatomy, Physiology and Diseases of the Eye.
Authors: James Moores Ball
Journal: JAMA (1904)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Electronic Drug Labels
Authors: Tracy Hampton
Journal: JAMA (2005)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Calcium spirulan derived from Spirulina platensis inhibits herpes simplex virus 1 attachment to human keratinocytes and protects against herpes labialis
Authors: Julia Mader, Antonio Gallo, Tim Schommartz, Wiebke Handke, Claus-Henning Nagel, Patrick Günther, Wolfram Brune, Kristian Reich
Journal: Journal of Allergy and Clinical Immunology (2015)
Evolution of gene order conservation in prokaryotes
Authors: Javier Tamames
Journal: Genome biology (2001)

As more complete genomes are sequenced, conservation of gene order between different organisms is emerging as an informative property of the genomes. Conservation of gene order has been used for predicting function and functional interactions of proteins, as well as for studying the evolutionary relationships between genomes. The reasons for the maintenance of gene order are still not well understood, as the organization of the prokaryote genome into operons and lateral gene transfer cannot possibly account for all the instances of conservation found. Comprehensive studies of gene order are one way of elucidating the nature of these maintaining forces.Gene order is extensively conserved between closely related species, but rapidly becomes less conserved among more distantly related organisms, probably in a cooperative fashion. This trend could be universal in prokaryotic genomes, as archaeal genomes are likely to behave similarly to bacterial genomes. Gene order conservation could therefore be used as a valid phylogenetic measure to study relationships between species. Even between very distant species, remnants of gene order conservation exist in the form of highly conserved clusters of genes. This suggests the existence of selective processes that maintain the organization of these regions. Because the clusters often span more than one operon, common regulation probably cannot be invoked as the cause of the maintenance of gene order.Gene order conservation is a genomic measure that can be useful for studying relationships between prokaryotes and the evolutionary forces shaping their genomes. Gene organization is extensively conserved in some genomic regions, and further studies are needed to elucidate the reason for this conservation.
Paracoccidioidomycosis presenting in the U.K.
Authors: S.L. Walker, A.C. Pembroke, S.B. Lucas, F. Vega-Lopez
Journal: British Journal of Dermatology (2007)

Conflicts of interest: none declared. Sir, A 51‐year‐old British man presented to the Hospital for Tropical Diseases with a 7‐month history of plantar pruritus and painful cutaneous lesions on his legs, face and feet. The lesions had bled and discharged at times. He had also lost 20 kg in weight and complained of cough and dyspnoea. There was no significant medical history and he was not taking any medications. He smoked 30 cigarettes per day and drank moderate amounts of alcohol. He had worked as an accountant in Maracaibo and Caracas in Venezuela for 20 years and had visited rural areas on business. He returned to the U.K. 2 months after the onset of this illness. On examination, he was afebrile, cachectic but in no acute distress. There were tender erythematous and purpuric macules and exophytic verrucous nodules on the legs and feet bilaterally (Fig. 1a, b). A hyperkeratosis of both plantar regions was noted. The oral cavity was normal but there were small hyperkeratotic nodules adjacent to the commissures. Respiratory examination revealed widespread coarse crackles and wheeze throughout both lung fields. The liver was palpable 4 cm below the right costal margin.
Alexander Macdougal Cooke James Rollo Ballantyne Roger Malcolm Richard Barnes Evan Fletcher John Nigel Harcourt-Webster Samuel ("Stanley") Leslie Isaacs Jack Joseph Sidney Levine John Stewart Mather George Ranken Tudhope
Authors: D. Pyke, J. Ballantyne, P. Johnson, P. Davidson, A. Lant and Simon Harcourt-Webster, N. Pollitt and Eric Fine, M. Stratton, N. Berlyne, R L Gadd and Maud Mather, J. McEwen, D. Tudhope
Journal: BMJ (1999)

He went into the Royal Flying Corps in the first world war, but it ended just before he could start serious shooting.After qualifying he was appointed the only medical registrar at St Thomas's.He did not get the expected appointment; instead (a great stroke of luck he considered it
Reduced Retinoic Acid-Sensitivities of Nuclear Receptor Corepressor Binding to PML- and PLZF-RARα Underlie Molecular Pathogenesis and Treatment of Acute Promyelocytic Leukemia
Authors: Fabien Guidez, Sarah Ivins, Jun Zhu, Mats Söderström, Samuel Waxman, Arthur Zelent
Journal: Blood (1998)
Britain's new strategy for tackling drugs misuse
Authors: M. Farrell, J. Strang
Journal: BMJ (1998)

News p 1411 

The UK government is to be congratulated on the launch of its new drug strategy,1 but probably not for the reasons it might expect. The greatest praise is due not so much for any specific policy proposal—these are rather predictable—but for the discipline and integrity the government has shown in preparing a national drug strategy that is more seriously committed to evidence than to rhetoric. With such a principle established the government is now well positioned to revise the strategy as new evidence becomes available and to advance drug policy in a manner similar to the advancement of evidenced based medicine. In this we hope that the government will establish the same requirements across all sectors—in prevention and enforcement as well as in treatment.

In 1997-8 the total government drug related expenditure was estimated at £1.4 billion ($2.2 billion), 62% of it spent on enforcement activity.1 Yet the strategy document points out that much of this is reactive and not specific to drugs. The rest of the spending is split, with 13% on treatment, 12% on …
Abstract 13490: Patterns of In-Hospital Management and Disposition of Patients Over 90 Years of Age Admitted with an Acute Coronary Syndrome at a Tertiary Medical Center
Authors: Nicolas W Shammas, Gail A Shammas, Carolyn Shanks, Amanda Dvorak, Patricia Serrano, Christine Harb, Cara M Voelliger, Christopher Koepke, Michael Jerin
Journal: Circulation (2014)

Introduction: It is estimated that by 2020 there will be 2.6 million nonagenarians and 135,000 centenarians in the United States. The in-hospital management and disposition of these patients remain poorly defined. Hypothesis: We describe in-hospital management and disposition of patients over the age of 90 years presenting with an acute coronary syndrome (ACS) at a tertiary medical center. Methods: All patients admitted between January 1, 2008 to December 31, 2012 with the diagnosis of an ACS and are over the age of 90 were included in this study. Demographic, clinical variables, in-hospital treatment, and post-hospital disposition were reviewed from medical records. The use of aspirin (ASA), beta-blockers, statins, ACEI/ARB, clopidogrel and aggressive versus conservative management were recorded. Results: 109 patients (13.9% males) were included. Demographics and clinical variables were as follows: Prior CAD 63.3%, prior MI 25.7%, renal insufficiency 33%, HT 80.7%, hyperlipidemia 45%, DM 23.9%, heart failure 30.3%, dementia 15.6%, smoking history 21.1%, and atrial fibrillation 22%. Patients were admitted from home 50.9%, nursing home/assisted living 35.2%, transfer from a local cath lab 12% and from primary care physician’s office 1.2%. ACS symptoms consisted of UA 23.9%, NSTEMI 65.4%, STEMI 11%. Coronary intervention was performed in 43.5%. Conservative management was driven by: dementia 4.6%, patient or family wishes 34.2%, physician 13%, non-treatable disease 4.6%. Pharmacologic management on discharge included ASA 82.1%, beta blockers 72%, statins 41.1%, ACEI 31.5%, ARB 8.3%, clopidogrel 52.4%. In-hospital mortality was 8.4% (cardiac related 7.5%) and length of hospital stay was 4.8 ± 4 days. Patients were discharged to home with visiting nurse (VN) support 30.1%, without VN 7.8%, to a family member’s home 4.9%, nursing home 29.1%, skilled nursing/rehabilitation 15.5%, and hospice 5.8%. Conclusions: In-hospital mortality rates of patients over the age of 90 is acceptable. Frequently these patients are treated with PCI. Conservative management is mostly guided by the patient and family wishes. Unfortunately, these patients remain markedly undertreated with standard post MI or UA drugs. Less than half of these patients returned home.
THE RÔLE OF DESENSITIZATION IN RECOVERY FROM BACTERIAL INFECTION
Authors: W. B. Wherry
Journal: Annals of Internal Medicine (1933)

Article1 December 1933THE RÔLE OF DESENSITIZATION IN RECOVERY FROM BACTERIAL INFECTIONW. B. WHERRYW. B. WHERRYSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-7-6-728 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptOur conception of what goes on during infection and recovery is bound to undergo a change from time to time, for our knowledge of biological processes is always incomplete and we are being perpetually subjected to the influence of new discoveries. The hypothesis I am going to present to you when carried to its logical conclusion is not clear in all its details, but it has directed us in our experimental work and has brought forth results which will aid us in combatting bacterial infections.An important factor in susceptibility and immunity, and one that largely has been overlooked, is...Bibliography1. FOSHAY L: Tularemia; accurate and earlier diagnosis by means of intradermal reaction, Jr. Infect. Dis., 1932, li, 286-291. CrossrefGoogle Scholar2. SCHÖBL O: Experimental yaws in Philippine monkeys and critical consideration of our knowledge concerning framboesia tropica in light of recent experimental evidence, Philippine Jr. Sci., 1928, xxxv, 209-332. Google Scholar3. BULLMCKEE CGCM: Sensitization of rabbits to products of pneumococcus resulting from acute infection with this organism, Am. Jr. Hyg., 1929, ix, 666-681. Google Scholar4. WHERRY WB: Tissue hydration and its relation to susceptibility and immunity as shown by skin tests in asthma, chronic sinusitis and other infections, Jr. Infect. Dis., 1927, xli, 177-189. CrossrefGoogle Scholar5. WHERRY WB: Hypersensitivity to bacterial proteins and its rôle in susceptibility and immunity, Am. Jr. Hyg., 1931, xiv, 539-554. Google Scholar6. DORSTHOPPHAN SEE: Angioneurotic edema: its relation to bacterial hypersensitivity, Jr. Lab. and Clin. Med., 1932, xviii, 7-11. Google Scholar7. ROCKWELL GE: The detoxification of pollen antigens, Jr. Bact., 1933, xxv, 100. Google Scholar8. FOSHAY L: Serum treatment of tularemia, Jr. Am. Med. Assoc., 1932, xcviii, 552. CrossrefGoogle Scholar9. FOSHAY L: Jr. Am. Med. Assoc. (In press.) Google Scholar10. O'NEIL AE: Preliminary note on the treatment of undulant fever in man with detoxified vaccine and with antiserum, Ohio State Med. Jr., 1933, xxix, 438-439. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: W. B. WHERRYAffiliations: Cincinnati, Ohio*Read at the Montreal Meeting of the American College of Physicians February 6, 1933. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byAllergic diseases 1 December 1933Volume 7, Issue 6 Page: 728-731 Keywords Immunity ePublished: 1 December 2008 Issue Published: 1 December 1933 PDF downloadLoading ...