tbuckley/cabot-search huggingface dataset:
The Growing Importance of Cardiovascular Radiology
Authors: Fred Jenner Hodges
Journal: New England Journal of Medicine (1956)

PHENOMENAL advances have occurred during the recent past in the diagnosis and treatment of cardiovascular disorders. Hand in hand, radiology and vascular surgery have provided a new and vigorous impetus to the conquest of hitherto unexplored fields with entirely new and highly specialized technics. In a brief span of years they have been developed to the point of great clinical utility. In the course of this development radiology has assumed a position of increasing importance in the management of patients who present cardiovascular problems.The great changes that have taken place in cardiovascular radiology in the United States began abruptly . . .
Epidermodysplasia verruciformis treated using topical 5-aminolaevulinic acid photodynamic therapy
Authors: S Karrer, R M Szeimies, C Abels, U Wlotzke, W Stolz, M Landthaler
Journal: British Journal of Dermatology (1999)

Journal Article Epidermodysplasia verruciformis treated using topical 5‐aminolaevulinic acid photodynamic therapy Get access S Karrer, S Karrer Department of Dermatology, University of Regensburg, D‐93042 Regensburg, Germany Search for other works by this author on: Oxford Academic Google Scholar R M Szeimies, R M Szeimies Department of Dermatology, University of Regensburg, D‐93042 Regensburg, Germany Rolf‐Markus Szeimies MD E‐mail: Rolf‐Markus.Szeimies@klinik.uni‐regensburg.de Search for other works by this author on: Oxford Academic Google Scholar C Abels, C Abels Department of Dermatology, University of Regensburg, D‐93042 Regensburg, Germany Search for other works by this author on: Oxford Academic Google Scholar U Wlotzke, U Wlotzke Department of Dermatology, University of Regensburg, D‐93042 Regensburg, Germany Search for other works by this author on: Oxford Academic Google Scholar W Stolz, W Stolz Department of Dermatology, University of Regensburg, D‐93042 Regensburg, Germany Search for other works by this author on: Oxford Academic Google Scholar M Landthaler M Landthaler Department of Dermatology, University of Regensburg, D‐93042 Regensburg, Germany Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 140, Issue 5, 1 May 1999, Pages 935–938, https://doi.org/10.1046/j.1365-2133.1999.02830.x Published: 01 May 1999
608. Dose Escalation of Recombinant Adenovirus-Based Influenza Virus Vaccine Encoding the Full Length Hemagglutinin (HA) of the A/Vietnam/1203/2004 (H5N1) To Immunize Naïve and Ad-Immune Mice
Authors: Julia Steitz, Wentao Gao, Edward Nwanegbo, Ruben O. Donis, Jacqueline M. Katz, Andrea Gambotto
Journal: Molecular Therapy (2006)

The recent emergence of highly avian influenza virus (HPAI) strains in poultry and their subsequent transmission to humans in Southeast Asia have raised concerns about the potential pandemic spread of lethal disease. We previously showed that recombinant adenovirus-based influenza A virus vaccine directed against the hemagglutinin (HA) protein of the A/Vietnam/1203/2004 (H5N1) can induce a 100% protection, associated with a cellular and humoral immune response, of mice and poultry against the lethal H5N1 avian influenza virus infection. In the present study we used the adenovirus encoding the full-length HA to analyze the humoral immune response after different dose of recombinant adenovirus. In view of clinical trials of the adenovirus-based influenza virus vaccine we determined the minimal amount of recombinant adenoviruses to induce the required titer measured by hemagglutination inhibition test. Due to the high frequency of anti-adenoviral immunity in the human population the efficiency of recombinant adenovirus-based vaccines are limited. To test the efficiency of the recombinant adenovirus-based influenza virus vaccine in the presence of neutralizing anti-adenoviral antibodies, we injected human IgG, which contains anti-adenoviral antibodies at a physiological level, before immunization. The result showed that 5|[times]|108 virus particle per mouse was the minimal amount to induce appropriate titers of antibodies. However, the immunization in the presence of neutralizing anti- adenoviral antibodies could only induce according antibody titer if we immunized with 5|[times]|1010 virus particle per mouse. This result improves our knowledge of the efficiency of recombinant adenoviral- based vaccines in the physiological situation in humans and is important for the design of clinical trials.
Metastatic Epidural Bacterial Abscess in a 4-Year-Old Boy
Authors: Seth DeVries
Journal: JAMA Neurology (2013)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Neurology HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Neurology journal
Infections in Children
Authors: Jerry J. Eller
Journal: JAMA (1983)

This volume is designed as a textbook and reference book for pediatricians and family physicians and all who provide primary and secondary care for children. There are two major divisions. Following an opening section on susceptibility and resistance, the first division consists of an approach to infections from the clinical viewpoint of signs and symptoms related to organ system dysfunction. The second major division approaches infections according to the type of agent. Information is easily found through chapter headings and a detailed cross-reference index. There are 108 chapters and 100 contributors. All of the chapters are well written. More than a few are outstanding. Many of the authors are distinguished investigators in the particular areas of discussion. Each chapter concludes with a bibliography, which contains a careful review of recent, as well as historical, key references.  The first ten chapters offer a concise review of theoretical principles and practical applications
Amount of research interest in rare and common neurological conditions: bibliometric study
Authors: R. Al-Shahi, R. G Will, C. P Warlow
Journal: BMJ (2001)

Neurologists are often accused of being interested in only rare incurable diseases. Although this may have been true in the past, today's neurologists claim to be more concerned with common disorders—but are they really?

We derived a “publication ratio” to measure the amount of research interest in 44 conditions representative of the spectrum of neurological disorders, for which there are population based estimates of frequency.1 We divided the number of Medline papers published in 1998 about each condition (in which their MeSH term was the focus of the paper) by a measure of their frequency (incidence or prevalence) × 100 000. When counting the number of publications, the investigator (RAS) was blinded to the frequency of each disease.



Publication ratios for 44 neurological conditions ordered by their incidence (top) and prevalence (bottom)



Far more papers investigated rare as opposed to common neurological disorders when the relative frequencies …
Irritant effects of formaldehyde exposure in mobile homes.
Authors: K S Liu, F Y Huang, S B Hayward, J Wesolowski, K Sexton
Journal: Environmental Health Perspectives (1991)

This paper reports the irritant effects associated with formaldehyde exposures in mobile homes. Week-long, integrated formaldehyde concentrations were measured using passive monitors in summer and winter while the mobile home residents continued their normal activities. Information on acute health problems, chronic respiratory/allergic illnesses, smoking behavior, demographic variables, and time spent at home was obtained on over 1000 individuals during the sampling period. Measured formaldehyde concentrations varied from under the limit of detection (0.01 ppm) to 0.46 ppm. Formaldehyde exposure was estimated for each individual by multiplying the concentration measured in his or her home by the time he or she spent at home. Irritant effects were found to be associated with formaldehyde exposure after controlling for age, sex, smoking status, and chronic illnesses using a logistic procedure. Some of the interaction terms found to be significant indicated that there were synergistic effects between formaldehyde exposure and chronic health problems.
Emergency in emergency departments.
Authors: J Marrow
Journal: BMJ (1977)

Relation of lecithin :sphingomyelin ratio (LSR) to presence of vernix in amntiotic fluxid LSR I Total ;2 !2 1-3 >3 No vernix seen 17 12 4 33 Cloudy, with doubtful 0 4 8 12 presence of vernix Vernix definitely present 0 5 29 34 Total 17 21 41 79Z2= 3487; DF 4; P <0(001; contingency coefficient 0-55.LSR is sometimes found in clear amniotic fluid, no immature LSR (> 2) was seen whenever vernix was present.Our findings suggest that amnioscopy might be used to assess fetal maturity before induction of labour.Induction can proceed if vernix is seen in the amniotic fluid and amniocentesis for the measurement of amniotic fluid LSR need be performed only when no vernix is seen.
Iraq doctor tells of health crimes
Authors: Ronald Labonte
Journal: BMJ (2005)

Delegates to the People's Health Movement assembly in Cuenca (18-23 July) also heard of alleged crimes against health in Iraq.

Iraqi physician Dr Salam Ismael claimed in a passionate testimony that “Crimes against health have been committed for two years in my country, and no one knows about them.” Speaking on behalf of the organisation Doctors for Iraq, he described a number of alleged violations to human rights since occupation.

The organisation of 250 doctors was founded in 2003 to do research, give humanitarian relief, and promote the right to health. It …
De novo mutations in the autophagy gene WDR45 cause static encephalopathy of childhood with neurodegeneration in adulthood
Authors: Hirotomo Saitsu, Taki Nishimura, Kazuhiro Muramatsu, Hirofumi Kodera, Satoko Kumada, Kenji Sugai, Emi Kasai-Yoshida, Noriko Sawaura, Hiroya Nishida, Ai Hoshino, Fukiko Ryujin, Seiichiro Yoshioka, Kiyomi Nishiyama, Yukiko Kondo, Yoshinori Tsurusaki, Mitsuko Nakashima, Noriko Miyake, Hirokazu Arakawa, Mitsuhiro Kato, Noboru Mizushima, Naomichi Matsumoto
Journal: Nature Genetics (2013)
Modified Cardiac Catheter For Neonate and Infant
Authors: Joshua Lynfield
Journal: JAMA (1966)

<h3>To the Editor:—</h3> Cardiac catheterization and selective angiocardiography carry an increased risk in the neonatal period and early infancy.<sup>1,2</sup>This communication reviews some of the problems associated with the use of cardiac catheters for diagnostic procedures, and describes a new modified pediatric NIH catheter designed to reduce the risks and increase the accuracy of those procedures in the neonate and small infant. Two principal types of catheter are in use for cardiac catheterization and angiocardiography. The first type, with an end hole, such as the Lehman catheter, has certain disadvantages for selective angiocardiography because of its tendency to recoil during injections. In addition, it is stiff and this increases the difficulties and dangers of intracardiac manipulation. Undesirable damping and difficulty with sampling may also occur with this catheter. The second type is the side-hole catheter which overcomes these difficulties and permits sampling and pressure recording as well as rapid
Planning trauma care services in the UK
Authors: J. O. Jansen, N. R. M. Tai, M. J. Midwinter
Journal: BMJ (2013)

Surgical workforce development remains a challenge 

In response to a 2011 analysis by the Centre for Workforce Intelligence on regional trauma networks,1 the Royal College of Surgeons of England began compiling a report, to be published in spring 2013, that illustrates the need for, and defines the shape of, specific training paths in trauma surgery. In 2006, a BMJ editorial, published in the wake of the 2005 terror attacks in London, highlighted deficiencies in the delivery of trauma care and the training of general trauma surgeons in the United Kingdom.2 Six years on, healthcare policy has changed greatly, and trauma infrastructure is rapidly evolving. However, there is still an urgent need for the development of training routes for specialist trauma surgeons.

In 2010, the UK’s first trauma system was set up in London. It was built around four trauma networks, comprising a major trauma centre and several associated units, which were governed by a system of triage and bypass protocols. The aim was to treat “the right patient, at the right place, at …
"STANDARDS OF OPHTHALMOLOGY"
Authors: Almer Coe
Journal: JAMA (1924)

To the Editor:  —I have read inThe Journalof July 26 the article on Standards of Ophthalmology, by Dr. George S. Derby of Boston. I am prompted to reply to this because of the statement made in that article as follows: The retail profit on glasses is large (100 per cent. seems to be a fairly good estimate. This statement, I hold, is unfair, misleading and harmful. Harmful because such things are read by many outside the profession, and because of the wide circulation and authoritative status ofThe Journal.  Our firm is classed, I believe, and perhaps properly so, as one of the leading dispensing houses of the country, and the leading one west of the Alleghanies. We confess to having had at least a fair degree of financial success, and after many years, from a modest start by the writer, now are doing what might be considered
Acute Alterations of Body Composition after Open Intracardiac Operations
Authors: ALBERT D. PACIFICO, STAN DIGERNESS, JOHN W. KIRKLIN
Journal: Circulation (1970)

The body composition of patients with heart disease is acutely altered by surgical intervention. Interrelations and causes of the alterations have not been clear. Twenty patients were studied preoperatively and again 2 to 4 days after open intracardiac operations. In nine, measurements were made of the volumes of total body water, extracellular water, plasma, and red cells, and of the amounts of total exchangeable sodium and potassium. In an additional four patients total exchangeable sodium and potassium were measured, and in another seven only exchangeable sodium was measured. Calculations were made of the intracellular and extracellular distribution of water and potassium. The significant changes ( P &lt; 0.05) occurring during the interval between studies were increase in extracellular water (7%), interstitial water (12.5%), and exchangeable sodium (9.4%), decrease in total exchangeable potassium (8.5%) and amount (8.7%), and concentration (6.9%) of calculated intracellular potassium. Uptake of sodium and water by the patient during cardiopulmonary bypass and postoperative loss of intracellular potassium with its secondary renal excretion are postulated as being etiologic. These findings imply that sodium intake in the early postoperative period should be low, water intake no more than urinary and insensible losses, and that potassium should be administered.
Are African governments allocating sufficient resources to fight AIDS?
Authors: P. Matchaba
Journal: BMJ (1999)

Intranasal corticosteroids in allergic rhinitis Paper did not include all data on adverse effectsEditor-Weiner et al conclude that "results from [their] systematic review, together with data on safety and cost effectiveness, support the use of intranasal corticosteroids over oral antihistamines as first line treatment for allergic rhinitis." 1 They also state that "intranasal corticosteroids are considered safe [and] studies have failed to show significant effects on serum markers of bone metabolism and short term bone growth," referring to two studies, those by Martinati et al and Wolthers et al.They make no reference to two more recent studies, both of a larger number of subjects over longer periods, which established a significant reduction in paediatric bone growth. 2 3The issue of adverse effects was also addressed in a report by the Committee on Safety of Medicines and Medicines Control Agency, which concluded that intranasal corticosteroids can cause "clinically important systemic adverse effects at licensed doses." 4 The United Kingdom datasheet for Beconase aqueous nasal spray (beclomethasone dipropionate) recognises the potential for children to develop growth retardation at licensed doses and the need to refer patients to paediatric specialists while they are being prescribed intranasal corticosteroids (Allen and Hanburys, Sept 1998).I question the omission of such key data from Weiner et al's systematic review; it may well tip the risk:benefit ratio away from the use of intranasal corticosteroids in children and, hence, affect the validity of the review's conclusions.
Paradoxical Haematemesis in Oesophageal Atresia
Authors: E. R. Lecutier
Journal: BMJ (1955)

Paradoxical Haematemesis in Oesophageal AtresiaAn essential prerequisite for the diagnosis of oesophageal atresia is to have the condition in mind.From the vari- ations in its reported incidence it seems probable that in some areas the diagnosis is less frequently considered than in others.However, it may happen that because of the co- existence of an additional condition the diagnosis may be delayed or even missed altogether.As the subsequent case report shows, the occurrence of haematemesis in a case of oesophageal atresia might well obscure the diagnosis, and so lead to undesirable delay in operative treatment.CASE REPORT ,A primipara aged 35 was delivered of an apparently normal male child in her own home on the evening of October 9,
Intercellular junctions and the permeability barrier in human sebaceous glands
Authors: N. KITSON, E. W. LENNEP
Journal: British Journal of Dermatology (2006)

Human sebaceous glands were studied by electron microscopy using lanthanum tracer and freeze‐fracture methods. Gap junctions but no tight junctions were found. It is suggested that the essential permeability barrier may be formed by the secreted sebaceous neutral lipid.
Virus-induced airway hyperresponsiveness. Role of inflammatory cells and mediators.
Authors: G Folkerts, F P Nijkamp
Journal: American Journal of Respiratory and Critical Care Medicine (1995)

Viral respiratory infections induce airway hyperresponsiveness in asthmatic patients, in healthy persons, and in a number of animal species. In asthmatics the degree of airway hyperresponsiveness is associated with the severity of exacerbations. The respiratory tract of an asthmatic is inflamed, and these inflammatory cells might be involved in modulating airway responsiveness. In contrast, no data are available on the role of bronchoalveolar cells in the airways of "healthy" persons or asthmatic patients suffering a respiratory tract infection. Because of the lack of information on this issue, the present review has been written. A number of animal studies have now been performed suggesting the involvement of inflammatory cells during a viral respiratory infection. The changes in number and activity of bronchoalveolar cells after a viral infection have been compared with changes in airway morphology and the development of airway hyperresponsiveness. Based on these data we suggested, the following hypothesis: Viruses damage the epithelial layer of the respiratory tract and activate bronchoalveolar cells. Subsequently, a number of mediators are released that can stimulate metachromatic cells, which in turn release products that increase vascular permeability and attract inflammatory cells that might cause additional epithelial damage. Finally, the released mediators and the morphologic changes together results in airway obstruction and the development of hyperresponsiveness.
<sup>125</sup>I Therapy in Graves' Disease
Authors: I. R. McDOUGALL
Journal: Annals of Internal Medicine (1976)

Because of the physical and radiobiologic differences between 125I and 131I, a trial using 125I to treat hyperthyroidism was undertaken in the hope of controlling hyperthyroidism without causing subsequent hypothyroidism. Three hundred fifty-five patients with diffuse toxic goitres were treated and have been under review for an average of 49.4 months: 63.4% are euthyroid, 33.5% are hypothyroid, and 3.1% remain hyperthyroid. Different groups of patients received a wide range of doses of 125I (4.0 to 56.0 mCi), and the lowest incidence of hypothyroidism (23%) was in the group that received between 6.0 and 10.5 mCi. Sixty-three percent of the patients whose initial dose was greater than 20.0 mCi are hypothyroid. Persistent hyperthyroidism was common in patients who received small doses. Because of the high incidence of posttreatment hypothyroidism in this series and because 131I has stood the test of time, we believe that 131I is the radionuclide of choice for the routine treatment of hyperthyroidism.
Randomized Comparison of Upstream Tirofiban Versus Downstream High Bolus Dose Tirofiban or Abciximab on Tissue-Level Perfusion and Troponin Release in High-Risk Acute Coronary Syndromes Treated With Percutaneous Coronary Interventions
Authors: Leonardo Bolognese, Giovanni Falsini, Francesco Liistro, Paolo Angioli, Kenneth Ducci, Tamara Taddei, Roberto Tarducci, Franco Cosmi, Silvia Baldassarre, Antonio Burali
Journal: Journal of the American College of Cardiology (2006)
Metabolic studies in mitral valve prolapse syndrome. A neuroendocrine--cardiovascular process.
Authors: H Boudoulas, J C Reynolds, E Mazzaferri, C F Wooley
Journal: Circulation (1980)

Symptomatic patients with mitral valve prolapse (MVP) frequently mimic thyrotoxicosis, hyperadrenergic states or hypoglycemia. Twenty symptomatic patients with auscultatory and echocardiographic MVP were studied in the clinical research unit. T3, T4 and plasma cortisol were normal. Patients with MVP had normal responses to oral glucose administration but higher glucose levels than the controls (p less than 0.05). Twenty-four-hour urinary epinephrine (E) and norepinephrine (NE) were greater than normal (E + NE excretion, 44 +/- 2 vs 29.5 microgram/g creatinine, p less than 0.001). The short electromechanical systole corrected for heart rate (529 +/- 3.9 vs normal 548 +/- 2 msec, p less than 0.01) also reflected high adrenergic tone. Frequent premature ventricular complexes (PVCs) with couplets and triplets were found in 14 patients. Catecholamine excretion and frequency of PVCs were parallel and both decreased significantly at night (p less than 0.001). Plasma catecholamine increase with exercise was greater in patients in whom the number of PVCs increased more than 10 per minute compared with patients in whom the number of PVCs remained relatively unchanged (620 +/- 80 vs 98 +/- 20 msec, p less than 0.01). We conclude that symptomatic patients with MVP have high adrenergic tone that may be responsible for or contribute to the multiple symptoms.