tbuckley/cabot-search huggingface dataset:
Prevalence of sleep disorders in the Los Angeles metropolitan area
Authors: Edward O Bixler, A. Kales, C. R. Soldatos, J. D. Kales, S. Healey
Journal: American Journal of Psychiatry (1979)

The authors determined the prevalence of sleep disorders in a general population through a survey of 1,006 representative households in the Los Angeles metropolitan area. They found an overall prevalence of current or previous sleep disorders in adults of 52.1%. Specifically, they found a 42.5% prevalence of insomnia, 11.2% of nightmares, 7.1% of excessive sleep, 5.3% of sleeptalking, and 2.5% of sleepwalking. These conditions were often chronic and usually started early in life. Insomnia was more frequent in older people, particularly older women, and in people of lower educational socioeconomic status. Insomnia, nightmares, and hypersomnia were correlated with more frequent general physical and mental health problems.
Transplantable Chloromyeloid Leukemia in Sprague-Dawley Rats Following Injection of Actinium-227&lt;xref ref-type="fn" rid="FN1"&gt;2&lt;/xref&gt;
Authors: Robert E. Zipf, Lois Chiles, Marietta Miller, Bernard J. Katchman
Journal: JNCI Journal of the National Cancer Institute (1959)

Chloroleukemia in the Sprague-Dawley rat presumably initiated by actinium-227 (actinium-equilibrium mixture) has been successfully transplanted in suckling rats over a period of 4 years. The morphologic and anatomic characteristics are described and found to be similar to those induced by methylcholanthrene. The successful transfer of the chloroleukemia in suckling rats was accomplished with an intraperitoneal injection of 0.1 to 0.2 ml. of leukemic whole blood without any detectable changes, after 4 years of transplantation, in either morphologic and anatomic properties or the lifespan of the leukemic animal. The chloroleukemia was also successfully transplanted in suckling rats by injection of tissue homogenates obtained from leukemic rats. The longevity of the animals injected with successful transplants appears to be a function of the number of myelocytes injected. This fact plus our inability to obtain successful transplants of the chloroleukemia with cell-free extracts leads us to conclude that leukemogenesis occurs most likely through a process of Colonization.
Abstract 287: Formation of Temporary Niches Is Required for Bone Marrow Cells To Adopt the Cardiomyogenic Fate In Vivo
Authors: Marcello Rota, Jan Kajstura, Toru Hosoda, Claudia Bearzi, Serena Vitale, Grazia Esposito, Grazia Iaffaldano, Elena Padin-Iruegas, Arantxa Gonzalez, Roberto Rizzi, Narissa Small, John Muraski, Xiongwen Chen, Konrad Urbanek, Roberto Bolli, Steven R Houser, Annarosa Leri, Mark A Sussman, Piero Anversa
Journal: Circulation (2007)
Differences in adherence to inhaled steroid medication in COPD
Authors: Marjolein Brusse-Keizer, Paul van der Valk, Job van der Palen
Journal: European Respiratory Journal (2011)

Objective:  To study whether COPD patients on medication combining an inhaled steroid with a long-acting bronchodilator show better therapy persistence than patients with inhaled steroids alone.   Methods:  This study is part of a cohort study with 3 years of follow-up (COMIC study). In total 800 patients were included. Therapy adherence was recorded from patients9 pharmacy records and was expressed as a percentage that was deemed good if it was 75–125%, sub-optimal between 50-75%, and poor below 50% or above 125%.   Results:  In total 664 (83%) patients used inhaled steroids and 60.8% showed good compliance. We observed a significant difference in therapy adherence between the studied medications (p 125%) adherence, while Salmeterol/Fluticason had a higher percentage of patients with sub-optimal adherence.   Conclusions:  This study showed that a significant proportion of patients with COPD is poorly adherent to inhaled corticosteroid therapy. Furthermore, adherence rates differed significantly between the studied inhaled steroids and the combinations of inhaled steroids and LABA. Contrary to our hypothesis, the adherence did not seem to be higher in the combined medications in comparison to the inhaled steroids alone, and in some cases it was even worse.
Abstract 525: Abnormal Left Ventricular Circumferential Strain, Strain Rate and Rotation Parameters Using Speckle Tracking Imaging in Acute Myocarditis as Evidenced on Cardiac Magnetic Resonance Imaging
Authors: Nee Scze Khoo, Kimberley Myers, Jeffrey Smallhorn, Ian Paterson
Journal: Circulation (2009)

Acute myocarditis with preserved LVEF are difficult to detect by conventional echocardiography. CMRI is the non-invasive reference standard for diagnosis. Known LV mechanics suggests disease in epi...
VARYING CLINICAL MANIFESTATIONS OF DEPRESSION
Authors: S H ROBERTSON
Journal: Annals of Internal Medicine (1954)

Article1 August 1954VARYING CLINICAL MANIFESTATIONS OF DEPRESSIONSYLVAN H. ROBERTSON, M.D.SYLVAN H. ROBERTSON, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-41-2-299 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe non-psychiatrist, the internist primarily, encounters patients in whom depression is not easily recognized. Variations in the symptoms do not point to the primary syndrome. Both the patient and the doctor may be unaware that the patient is depressed. The doctor's preoccupation with the physical complaints that may be suggestive of pathologic organic alterations produces a search for somatic disease and, when no disease is found, the patient is left with the hollow reassurance that he is well. The diagnosis becomes psychoneurosis and, if the patient can continue to work, the physician may feel that his job is done.It... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Chicago, Illinois*Received for publication January 29, 1954.From the Department of Internal Medicine, University of Illinois, and the Department of Medicine, Michael Reese Hospital, Chicago. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 August 1954Volume 41, Issue 2Page: 299-304KeywordsHospital medicine ePublished: 1 December 2008 Issue Published: 1 August 1954 PDF downloadLoading ...
Another Report of Familial Spontaneous Coronary Artery Dissection
Authors: Anthony J. White, Yuvaraj Malaiapan, Ian T. Meredith
Journal: JAMA Internal Medicine (2015)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Internal Medicine HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Internal Medicine journal
Abstract 1167: A Path To Vascular Disease Through The Biological Clock
Authors: R. Daniel Rudic, Ciprian B Anea, David W Stepp, G. Bryan Simkins, Guy Reed, David J Fulton
Journal: Circulation (2007)

Cardiovascular disease is the leading cause of death for both men and women in the United States and the world. There is a profound pattern in the time of day at which the death occurs; it is in the morning, when the endothelium is most vulnerable and blood pressure surges, that stroke and heart attack most frequently happen. Though the biological clock rhythmically oscillates in blood vessels, evidence of a direct function in the vasculature for Bmal1, an essential clock component, is lacking. We have found that chronic flow interruption in arteries of mice with targeted disruption of Bmal1 gene (Bmal1-KO) causes pathological vascular remodeling which worsens to thrombosis with ageing. In addition, naïve aortic arteries of Bmal1-KO mice exhibit endothelial dysfunction, which is improved by relief of oxidant stress. Akt signalling, a pathway critical to vascular function, was significantly attenuated in arteries of Bmal1-KO mice. Co-transfection of cultured cells with the transcription factors Bmal-Npas2 or Bmal1-Clock induced a robust activation of the Akt promoter, providing evidence of a direct link between the circadian clock and Akt pathways. Our data reveals a new role for the biological clock in the control of endothelial signalling and vascular remodeling which may be of significant impact in the progression of vascular disease.
Developing a patient reported experience measure for COPD
Authors: Michael Roberts, Sharon Andrew, Susan Walker, Matthew Hodson, Robyn Hudson
Journal: European Respiratory Journal (2012)

Introduction  The patient experience and patient outcomes are metrics for quality improvements in healthcare. There is no currently available patient reported experience measure (PREM) for COPD.  Study Aim  The aim of the study is to create a valid and reliable PREM for patients with COPD.  Methods  Sixty four people with COPD across the community of North East London, North Central London and Essex and 19 with recent hospital experience were interviewed to capture their patient journey with COPD. Analysis of the interview data was by a two layer approach:  content  and then by  affective  (emotive or felt) responses.  Results  Eighteen different  affective  responses were described by patients and were grouped as positive, negative or ambivalent. Positive responses included: hope, gratitude, comfort/ reassured, acceptance, optimism, altruism, happy and respect. Negative responses included scared, anxiety, fear, frustration, worry, feeling depressed, denial and embarrassment. 9Self-motivation9 and control were contextual and could be either positive or negative.  The community patient groups9 experience centred around five categories identified in the content analysis: 9Journey to Diagnosis9; 9Smoking9; 9Usual Care9; 9Exacerbation (9flare-up)9 and 9My Everyday Life9. The hospital patient experience was categorised as: 9Going to Hospital9; 9On Arrival to Hospital9; 9On the Ward9; 9Discharge from hospital9 and 9Follow-up care9. Items based on patients9 affective responses were generated from the categories to develop a PREM-COPD scale.  Conclusion  Completion of the testing of the PREM-COPD will result in a valid and reliable instrument to be used to measure self-defined important patient experiences when using healthcare services.
All-trans retinoic acid compromises desmosome expression in human epidermis
Authors: None Humphries, None Parry, None Watson, None Garrod, None Griffiths
Journal: British Journal of Dermatology (1998)

An undesirable side‐effect of retinoid treatment is skin fragility. As desmosomes are important in maintaining the cohesion of epidermal keratinocytes, we investigated whether all‐trans‐retinoic acid (RA) compromises desmosome expression in human epidermis, thereby predisposing skin to fragility. Solutions containing 0.025% RA, 5% sodium dodecyl sulphate (SDS) as an irritant control, or vehicle alone were applied to three sites on the buttocks of normal volunteers (n = 9). Treated sites were occluded for 4 days, and biopsies taken under local anaesthesia. Cryostat sections were stained with a panel of antibodies to desmosomal proteins and visualized by immunofluorescence microscopy. Stained sections were randomized and assessed for intensity of staining. The epidermal thickness of each treated site was quantified by image analysis. Western blots of epidermal desmocollins were quantified by densitometry. RA and SDS treatments significantly, but equivalently, increased epidermal thickness compared with vehicle. Immunohistochemically, both RA and SDS were shown to reduce epidermal staining for desmoplakin, desmoglein 1, plakophilin 1 and desmocollin 3 equally compared with vehicle‐treated skin (P< 0.001). RA produced a greater reduction in desmocollin 1 staining compared with SDS (P< 0.001). Similar reductions in desmocollins were found by Western blot analysis. Reduced desmocollin expression may indicate compromised desmosomal adhesion, leading to the skin fragility that results from retinoid treatment.
Long-term effect of fulvestrant on signaling elements in breast cancer.
Authors: A. Agrawal, J. F. Robertson, E. Gutteridge, I. O. Ellis, K. Cheung, R. I. Nicholson, S. Kyme, J. M. Gee
Journal: Journal of Clinical Oncology (2010)

1061 Background: We have previously presented first long-term human data (median time to progression [TTP] of 25.8 months) wherein treatment of breast cancer with fulvestrant (Faslodex) significantly decreased tumor expression of estrogen receptor (ER), progesterone receptor and proliferation marker, Ki67. We now present changes in HER2, phosphorylated HER2 (pHER2), epidermal growth factor receptor (EGFR), and phosphorylated mitogen activated phospho-kinase (pMAPK) in an attempt to begin to decipher the mechanism of resistance to fulvestrant. Methods: 32 ER+ postmenopausal women with measurable locally advanced (n=22) and metastatic breast cancer (n=10) had fulvestrant (250 mg. intramuscularly monthly) as first-line primary endocrine therapy. Immunohistochemical assays were performed on sequential core biopsies taken at diagnosis (before commencing fulvestrant, T1), 6 weeks (T2), 6 months (T3), and at progression (T4) of disease. Standard H scoring method was used for detection of immunoreactivity and nonparametric tests used for analysis. Results: P value (significance at p < 0.05) of changes at subsequent time points from pretreatment level on Wilcoxon analysis is shown in the Table. Kaplan-Meier analysis did not reveal any significant relation with TTP with any of the markers. Conclusions: This series with modest initial HER2/EGFR levels showed no significant increase at progression. This appears to differ from tamoxifen resistance in vitro and some tamoxifen-resistant patients. Interestingly, fulvestrant decreased pMAPK, which may contribute to response at 6 months through (decrease in) ligand-independent MAPK/ER cross talk, while lack of significant pMAPK fall at T4 suggests some pMAPK recovery may occur at relapse versus T3. Thus, MAPK needs to be investigated further for its role in development of fulvestrant resistance. Residual availability of ER and GFRs at progression also raises possibility of treatment with further anti- GFR agents either alone or in combination with anti-ER agents. Median H score at T1 (range) T1-T2 T1-T3 T1-T4 HER2, 55 (1-190) NS NS NS pHER2, 60 (4-280) NS NS NS EGFR, 57 (6-165) NS NS NS pMAPK,150 (15-300) NS p=0.032 NS Abbreviation: NS, nonsignificant. Author Disclosure Employment or Leadership Position Consultant or Advisory Role Stock Ownership Honoraria Research Funding Expert Testimony Other Remuneration AstraZeneca AstraZeneca AstraZeneca
Association Between Advances in High-Resolution Cross-Section Imaging Technologies and Increase in Prevalence of Pancreatic Cysts From 2005 to 2014
Authors: Maria Moris, Mellena D. Bridges, Robert A. Pooley, Massimo Raimondo, Timothy A. Woodward, John A. Stauffer, Horacio J. Asbun, Michael B. Wallace
Journal: Clinical Gastroenterology and Hepatology (2015)
Measuring quality of life: Is there such a thing as a life not worth living?
Authors: B. Farsides
Journal: BMJ (2001)

This is the last in a series of five articles 

Measuring quality of life has an important place in health care, but what about when life has no quality? Or worse? From an ethical perspective there are two areas in which these issues have been extensively explored: termination of pregnancy and end of life decision making for competent and non-competent adults. One way in which quality of life is sometimes introduced to decision making is through the concept of “a life not worth living.” The seemingly logical conclusion is that lives not worth living may not be worth creating or saving. This final paper in the series debates the problems—both the practical difficulties of measurement and ethical issues—associated with measuring quality of life in situations in which lives have been judged to have no quality.

#### Summary points

There are no quality of life measures that reliably identify patients who feel that life is not worth living

Basing management decisions on such measures requires extreme caution because of the fluctuating nature of patients' valuations of life and their desire for death

Patients who are dying may find some quality in life, even when their quality of life as assessed by current measures is abysmal

The use of proxies to determine whether a life is worth living is problematic because of the possible disparity between an observer's assessment and the patient's own valuation

Both patients and their proxies have identified health states that they consider to be worse than death

If a pregnancy is terminated because the fetus has an abnormality we will never know for sure whether the life in question would have been worth living. However, we allow lives to be terminated if they are predicted to be of low (or maybe only slightly diminished) quality. We base these decisions not only, …
A systematic review of transfusion-associated graft-versus-host disease
Authors: Ilana Kopolovic, Jackie Ostro, Hideki Tsubota, Yulia Lin, Christine M. Cserti-Gazdewich, Hans A. Messner, Amy K. Keir, Neal DenHollander, Walter S. Dzik, Jeannie Callum
Journal: Blood (2015)
Fracture Risk in Men With Congestive Heart Failure
Authors: Laura D. Carbone, Jessica D. Cross, Syed H. Raza, Andrew J. Bush, Robert J. Sepanski, Saurabh Dhawan, Bilal Q. Khan, Malini Gupta, Khurram Ahmad, Rami N. Khouzam, Dwight A. Dishmon, Joseph P. Nesheiwat, Mohammad A. Hajjar, Waqas A. Chishti, Wael Nasser, Mehwish Khan, Catherine R. Womack, Tara Cho, Ashley R. Haskin, Karl T. Weber
Journal: Journal of the American College of Cardiology (2008)
On The Treatment of Inoperable Cases of Carcinoma of the Mamma: Suggestions for a New Method of Treatment, with Illustrative Cases
Authors: G. T. Beatson
Journal: CA A Cancer Journal for Clinicians (1983)

CA: A Cancer Journal for Clinicians publishes information about the prevention, early detection, and treatment of cancer, as well as nutrition, palliative care, survivorship, and additional topics of interest related to cancer care.
Mutation analysis of a cohort of US patients with hemophilia B
Authors: Tengguo Li, Connie H. Miller, Jennifer Driggers, Amanda B. Payne, Dorothy Ellingsen, W. Craig Hooper
Journal: American Journal of Hematology (2013)

Hemophilia B (HB) is a disorder resulting from genetic mutations in the Factor 9 gene ( F9 ). Genotyping of HB patients is important for genetic counseling and patient management. Here we report a study of mutations identified in a large sample of HB patients in the US. Patients were enrolled through an inhibitor surveillance study at 17 hemophilia treatment centers. A total of 87 unique mutations were identified from 225 of the 226 patients, including deletions, insertions, and point mutations. Point mutations were distributed throughout the F9 gene and were found in 86% of the patients. Of these mutations, 24 were recurrent in the population, and 3 of them (c.316G&gt;A, c.1025C&gt;T, and c.1328T&gt;A) accounted for 84 patients (37.1%). Haplotype analysis revealed that the high recurrence arose from a founder effect. The severity of HB was found to correlate with the type of mutation. Inhibitors developed only in severe cases with large deletions and nonsense mutations. None of the mild or moderate patients developed inhibitors. Our results provide a resource describing F9 mutations in US HB patients and confirm previous findings that patients bearing large deletions and nonsense mutations are at high risk of developing inhibitors. Am. J. Hematol. 89:375–379, 2014. Published 2013.
Cellular Phosphorylation of 1-β-d-Arabinofuranosylcytosine and 5-Azacytidine with Intact Fibrosarcoma and Leukemic Cells
Authors: Thomas Lee, Myron Karon, Richard L. Momparler
Journal: Cancer Research (1975)

The phosphorylation of 1-β-d-arabinofuranosylcytosine (ara-C) and 5-azacytidine (5-aza-C) by A(T1)C1-3 hamster fibrosarcoma cells and L5178Y murine leukemic cells was studied, using intact cells. The cellular phosphorylation of both these nucleoside analogs appears to follow Michaelis-Menton kinetics. The apparent Km value for ara-C in the fibrosarcoma and leukemic cells was about 40 µm, whereas the apparent Km values for 5-aza-C in these cells were about 1.3 and 0.41 mm, respectively. Deoxycytidine and cytidine were found to be potent competitive inhibitors of the phosphorylation of ara-C and 5-aza-C, respectively. ara-C and 5-aza-C were found to be weak competitive inhibitors of the phosphorylation of deoxycytidine and cytidine, respectively. A clone isolated from the fibrosarcoma cells that was partially resistant to the cytotoxic effects of ara-C exhibited a higher Km value for both ara-C and deoxycytidine than the wild-type fibrosarcoma cells.
A matrikine-mediated pathway of MMP-9 release from neutrophils
Authors: Xin Xu, Patricia Jackson, Matthew Hardison, J. Edwin Blalock, Amit Gaggar
Journal: European Respiratory Journal (2011)

Introduction: Our group has previously characterized N-acetyl-Pro-Gly-Pro (Ac-PGP) as an important neutrophil (PMN) chemoattractant generated through collagen degradation by matrix metalloproteinase-9 (MMP-9). MMP-9 is present in PMN granules but whether Ac-PGP regulates MMP-9 release from these cells is unknown.

Aims: The aim of this study was to determine if Ac-PGP can mediate MMP-9 release from PMNs and to highlight the pathways which regulate this response.

Methods: Primary human blood PMNs were pretreated with and without an ERK1/2 MAPK inhibitor (U0126) or the CXCR1/CXCR2 inhibitor Repertaxin and then incubated with Ac-PGP. The cell supernatants and lysates were analyzed for MMP-9 levels and intracellular pathway activation, respectively. In addition, after stimultating PMNs with C13, N15 labeled Ac-PGP, supernatants were incubated overnight with type I collagen to measure the ongoing generation of Ac-PGP.

Results: We found that Ac-PGP induced significant release of MMP-9 (in a dose- and time-dependent manner) and activated the ERK1/2 MAPK pathway. This MMP-9 release was attenuated by an inhibitor of ERK1/2 and upstream blockade of CXCR1/CXCR2 with Repertaxin led to decreased MMP-9 release and ERK 1/2 activation. Supernatants obtained from PMNs stimulated by C13 N15 labeled Ac-PGP generated increased endogenous Ac-PGP when incubated with intact collagen; this effect was inhibited by an ERK1/2 pathway inhibitor.

Conclusions: These data indicate that ECM-derived Ac-PGP results in MMP-9 release from activated PMNs through the ligation of CXCR1 and CXCR2 and subsequent activation of the ERK1/2 MAPK, demonstrating a new pathway of matrikine-mediated protease regulation and subsequent “feed-forward” Ac-PGP production.