EFFECT OF OXYTETRACYCLINE THERAPY OF STREPTOCOCCAL SORE THROAT ON THE INCIDENCE OF ACUTE RHEUMATIC FEVER
Authors: Francis J. Catanzaro, Loring Brock, Robert Chamovitz, William D. Perry, Alan C. Siegel, Chandler A. Stetson, Charles H. Rammelkamp, Harold B. Houser, Bertrand L. Stolzer, Lewis W. Wannamaker, Edward O. Hahn
Journal: Annals of Internal Medicine (1955)

Article1 February 1955EFFECT OF OXYTETRACYCLINE THERAPY OF STREPTOCOCCAL SORE THROAT ON THE INCIDENCE OF ACUTE RHEUMATIC FEVERFRANCIS J. CATANZARO, LORING BROCK, ROBERT CHAMOVITZ, WILLIAM D. PERRY, ALAN C. SIEGEL, CHANDLER A. STETSON, CHARLES H. RAMMELKAMP JR., M.D., F.A.C.P., HAROLD B. HOUSER, BERTRAND L. STOLZER, LEWIS W. WANNAMAKER, EDWARD O. HAHNFRANCIS J. CATANZARO, LORING BROCK, ROBERT CHAMOVITZ, WILLIAM D. PERRY, ALAN C. SIEGEL, CHANDLER A. STETSON, CHARLES H. RAMMELKAMP JR., M.D., F.A.C.P., HAROLD B. HOUSER, BERTRAND L. STOLZER, LEWIS W. WANNAMAKER, EDWARD O. HAHNAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-42-2-345 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptAlthough penicillin, Chlortetracycline, Oxytetracycline and erythromycin have been shown to be effective in alleviating the symptoms of acute streptococcal disease, only penicillin and Chlortetracycline therapy have been shown to reduce the incidence of rheumatic fever following such infections.1-6 Since an important purpose of treatment is the prevention of complications, particularly rheumatic fever, it is necessary to evaluate the antirheumatic effect of each new drug employed in the therapy of streptococcal infections. In addition, the occurrence of reactions to the various drugs makes it essential that more than one form of therapy be available to the physician.The present study is...Bibliography1. BrinkRammelkampDennyWannamaker WRCHFWLW: Effect of penicillin and Aureomycin on natural course of streptococcal tonsillitis and pharyngitis, Am. J. Med. 10: 300, 1951. CrossrefMedlineGoogle Scholar2. DennyWannamakerHahn FWLWEO: Comparative effects of penicillin, Aureomycin, and Terramycin on streptococcal tonsillitis and pharyngitis, Pediatrics 11: 7, 1953. MedlineGoogle Scholar3. HaightFinland THM: Laboratory and clinical studies on erythromycin, New England J. Med. 247: 227, 1952. CrossrefMedlineGoogle Scholar4. Haight TH: Erythromycin therapy of respiratory infections. I. Controlled studies on the comparative efficacy of erythromycin and penicillin in scarlet fever, J. Lab. and Clin. Med. 43: 15, 1954. MedlineGoogle Scholar5. WannamakerRammelkampDennyBrinkHouserHahnDingle LWCHFWWRHBEOJH: Prophylaxis of acute rheumatic fever by treatment of the preceding streptococcal infection with various amounts of depot penicillin, Am. J. Med. 10: 673, 1951. CrossrefMedlineGoogle Scholar6. HouserEckhardtHahnDennyWannamakerRammelkamp HBGCEOFWLWCH: Effect of Aureomycin treatment of streptococcal sore throat on the streptococcal carrier state, the immunological response of the host, and the incidence of acute rheumatic fever, Pediatrics 12: 593, 1953. MedlineGoogle Scholar7. Jones TD: Diagnosis of rheumatic fever, J. A. M. A. 126: 481, 1944. CrossrefGoogle Scholar8. Streptococcal Disease Laboratory, to be published. Google Scholar9. StetsonRammelkampKrausePerryKohen CACHRMWDRJ: Epidemic nephritis, to be published. Google Scholar10. ChamovitzCatanzaroStetsonRammelkamp RFJCACH: Prevention of rheumatic fever by treatment of streptococcal infections. I. Evaluation of benzathine penicillin G, to be published. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: *Received for publication September 18, 1954.From the Streptococcal Disease Laboratory, Francis E. Warren Air Force Base, Wyoming, and the Department of Preventive Medicine, School of Medicine, Western Reserve University, Cleveland, Ohio.This investigation was conducted under the sponsorship of the Commission on Acute Respiratory Diseases and the Commission on Streptococcal Diseases, Armed Forces Epidemiological Board, and was supported by the Offices of The Surgeons General, Departments of the Army and Air Force, Washington, D. C.†Oxytetracycline (Terramycin) was generously supplied by Dr. Gladys L. Hobby, Charles Pfizer and Company, New York. 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ROSENBERG, M.D., F.A.C.P.PharyngitisPrevention of Rheumatic Fever by Treatment of Streptococcal InfectionsAntibacterial Drugs in the Prevention of Rheumatic FeverProphylaxis of Rheumatic FeverReview of the available literature of the pharynx and pharyngeal surgery for 1955The role of C-reactive protein in allergic inflammationCurrent pediatric references 1 February 1955Volume 42, Issue 2Page: 345-357KeywordsDrug therapyHyperthermiaPenicillinPharyngitisPreventive medicinePulmonary diseasesResearch laboratoriesRheumatic feverStreptococcal infectionsSurgeons ePublished: 1 December 2008 Issue Published: 1 February 1955 PDF downloadLoading ...