tbuckley/cabot-search huggingface dataset:
Restoration of impaired natural killer cell activity of B‐chronic lymphocytic leukemia patients by recombinant interleukin‐2
Authors: Neil E. Kay, Joyce Zarling
Journal: American Journal of Hematology (1987)

Abstract Natural killer (NK) function in the majority of B‐cell chronic lymphocytic leukemia patients is markedly deficient. This study was undertaken to determine if the biological response modifier interleukin‐2 (IL‐2), which is a potent augmenter of normal individuals' NK activity, could augment the low NK activity in these patients. Peripheral blood lymphocytes (PBL), depleted of B‐cells, from most B‐CLL patients exhibited low natural killer activity against NK‐sensitive K562 cells and against herpes simplex virus (HSV)‐infected lymphoblastoid cell lines (LCL). Incubation of patients' B‐cell‐depleted PBL with recombinant IL‐2 resulted in augmentation of their NK activity against both K562 cells and HSV‐infected cells. Furthermore, whereas large granular lymphocytes (LGL) isolated from CLL patients are deficient in cytoplasmic granules, which are thought to play a role in NK‐cell‐mediated lysis, treatment of patients' LGL resulted in increased granulation by 4 hr after treatment with IL‐2 and showed a concomitant increase in lytic activity comparable to that of normal individuals.
Further Psychiatric Investigations of Patients with Temporal and Nontemporal Lobe Epilepsy
Authors: JOYCE G. SMALL, IVER F. SMALL, MARY P. HAYDEN
Journal: American Journal of Psychiatry (1966)

Several recent reports in the literature on temporal lobe epilepsy have suggested that there are unique psychopathological manifestations in these patients. The present study, a modified double-blind evaluation of 50 patients with temporal lobe epilepsy and 50 controls with other types of convulsive disorders, was undertaken to test such a hypothesis. Although some patients with temporal lobe epilepsy did display the psychopathological attributes previously reported to be characteristic of these patients, some patients in the control group also displayed them. The authors conclude that temporal and nontemporal epilepsy cannot be distinguished by the incidence of certain concomitant mental disorders.
Low-Dosage<sup>131</sup>I Therapy of Thyrotoxicosis (Diffuse Goiters)
Authors: Jose L. Cevallos, Garrett A. Hagen, Farahe Maloof, Earle M. Chapman
Journal: New England Journal of Medicine (1974)

RADIOACTIVE iodine therapy effectively controls hyperthyroidism in the majority of patients treated. However, the subsequent appearance of hypothyroidism in some1 has been of increasing concern. There is a cumulative incidence of hypothyroidism after radioiodine that may affect a large percentage of patients 10 years after therapy.2 3 4 Hypothyroidism may also appear in an appreciable number of patients after subtotal thyroidectomy, reported as 28 per cent by Nofal and Beierwaltes, with similar results by others.4 5 6 Indeed hypothyroidism may follow as a late sequel to Graves's disease regardless of the type of therapy and has been considered part of the natural history of . . .
Her final days
Authors: Caleb Tucker
Journal: BMJ (2006)

health care of undocumented migrants, and Belgium, France, and Spain have special state health insurance.Healthcare professionals report that widespread confusion about these rules means that people who are fully entitled to all NHS care-refugees, asylum seekers, and ethnic minorities-are being wrongly denied access to primary and secondary care.Doctors' professional organisations, such as the British Medical Association and the Medical Practitioners Union, have expressed concerns that it is not the role of doctors to police eligibility for NHS care. 12 13 Project: London will help people to access the services that they are entitled to.Another key challenge will be to speak out about the fact that there are vulnerable people living in the UK who are being denied access to health care through the new entitlement rules.One of our roles will be to highlight their situation and to work with other concerned organisations to advocate for their right to access the medical care that they need.Project: London can take place thanks to the kind support of Tower Hamlets Primary Care Trust/Neighbourhood
"Meat-wrappers' Asthma"-Reply
Authors: E. J. Bardana
Journal: JAMA (1976)

We share Dr Aelony's pleasure with respect to the continuing interest in the respiratory problems of individuals exposed to components of PVC. We wish to emphasize that the term "meat-wrappers' asthma" is somewhat of a misnomer in that the spectrum of exposed individuals extends beyond the meatwrapper, and the pulmonary involvement may occur as acute reactive airway disease or a chronic disorder with both obstructive and restrictive patterns. Wegman<sup>1</sup>has reported fine nodular changes on the chest x-ray films of three workers of 37 exposed to PVC only. Significant restrictive disease was noted in a larger study of vital capacity and PVC workers by Lilis and his associates.<sup>2</sup> Recently, Maccia and his colleagues<sup>3</sup>have provided substantial evidence that phthalic anhydride (a component of some PVC soft wraps, and thermally activated labels) can induce clinical sensitization with high titers of specific IgE. Oddly enough, Kern<sup>4</sup>
Abstract 1525: RLIP76 transports sunitinib and sorafenib and mediates drug resistance in kidney cancer
Authors: Sharad S. Singhal, Archana Sehrawat, Mukesh Sahu, Preeti Singhal, Rit Vatsyayan, Poorna C R Lelsani, Sushma Yadav, Sanjay Awasthi
Journal: Cancer Research (2010)

Abstract RLIP76 is a stress-responsive membrane protein implicated in the regulation of multiple cellular signaling pathways. It functions as the predominant glutathione-electrophile conjugate (GS-E) transporter in cells. We have shown that RLIP76 plays a crucial role in defending cancer cells from radiation and chemotherapeutic toxin-mediated apoptosis, and its inhibition by antibodies or depletion by siRNA or antisense causes apoptosis in a number of cancer cell types. Recently, we have demonstrated for the first time the striking anti-neoplastic effects with no evident toxicity in terms of either weight loss or metabolic effects for the antibody, antisense and siRNA in a renal cell xenografts model of Caki-2 cells (Singhal et al., Cancer Res., 2009, 69: 4244). Present studies were performed to determine if RLIP76 targeting is more broadly applicable in other kidney cancer cell lines, to compare the signaling effects of RLIP76 antisense with kinase inhibitors used in treatment of renal cell carcinoma, and to determine whether kinase inhibitors were substrates for transport by RLIP76. Results of these studies show that sorafenib as well as sunitinib are substrates for transport by RLIP76 thus are competitive inhibitors of GS-E transport. Furthermore, kinase inhibition in the ERK as well as PI3K pathways by RLIP76 depletion is more profound and consistent and is more widely apparent in a number of renal carcinoma cell lines. These studies support the validity of RLIP76 as a target in kidney cancer therapy, and the functional model in which RLIP76 provides protection from chemical and radiant stress through its transport activity. Results of these studies revealed for the first time that sorafenib as well as sunitinib, receptor tyrosine kinase inhibitors (RTKIs), are substrates for transport by RLIP76. These studies offer strong support for our overall hypothesis that RLIP76 is an overarching anti-apoptosis mechanism that, if inhibited, can be more broadly effective in the treatment of renal cell carcinoma. (Supported in part by NIH Grants CA 77495 and CA 104661 (to SA), Cancer Research Foundation of North Texas (to SSS &amp; SY), Institute for Cancer Research and the Joe &amp; Jessie Crump Fund for Medical Education (to SSS)) Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 101st Annual Meeting of the American Association for Cancer Research; 2010 Apr 17-21; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2010;70(8 Suppl):Abstract nr 1525.
Diminished expression of integrin adhesion molecules on human colonic epithelial cells during the benign to malign tumour transformation.
Authors: A Stallmach, B von Lampe, H Matthes, G Bornhoft, E O Riecken
Journal: Gut (1992)

Integrins are transmembrane molecules that mediate cell-cell and cell-substratum adhesion. Because alterations in the adhesive properties of tumour cells are thought to influence tumour cell invasion, the expression of integrin alpha and beta chains in 19 human colorectal carcinomas, eight adenomas, and eight normal colon tissues was examined immunohistochemically using an indirect immunofluorescent technique. Normal colonic epithelial cells were found to express the integrin alpha 3, alpha 5, alpha 6, beta 1, and beta 4 chains, whereas the alpha 2 chain was expressed only on epithelial cells lining the base of the crypts and was absent from cells lining the mouth of the crypts or the surface epithelium. No epithelial staining of the alpha 1, alpha 4, beta 2, and beta 3 chains was observed. A progressive reduction of all normally expressed alpha and beta chains was associated with increasing neoplastic transformation. The expression of the alpha 3 and alpha 5 chains was already noticeably reduced in adenomas, and was completely absent in most colonic carcinomas. In contrast, alpha 6, beta 1, and beta 4 expression was maintained in adenomas, whereas the transformation from benign to malignant neoplasms associated with infiltrative growth was characterised by diminished or lost expression of alpha 6, beta 1, and beta 4 chains. Thus, the decreased expression of integrins in human colon carcinomas may contribute to the altered adhesion and migration properties of these tumour cells.
Aggressive amelanotic lentigo maligna
Authors: R.I. KELLY, M.G. COOK, P.S. MORTIMER
Journal: British Journal of Dermatology (2006)

A 66-year-old woman had a long-standing, scaly erythematous lesion on her left temple which histologically showed features of amelanotic lentigo maligna. It had recurred on numerous occasions over a period of 17 years, in spite of multiple attempts at curative surgery. There were also recurrences within a skin graft which, to our knowledge, has not been documented previously with lentigo maligna. In spite of the prolonged course, and extensive intraepidermal melanocytic proliferation amounting to melanoma in situ, there has been no evidence of dermal invasion. The lack of pigmentation in such lesions means that clinical definition of margins is highly inaccurate. In view of the aggressive horizontal growth phase of this lesion, with rapid recurrence following surgery, it was treated with electron beam therapy, and this has resulted in complete clinical remission. This most unusual case illustrates the potential difficulties in diagnosis and management of amelanotic lentigo maligna.
Unusual Location of a Liver ???Hot Spot??? in a Patient with Superior Vena Caval Obstruction
Authors: HEIDI S. WEISSMANN, LEROY A. SUGARMAN, NORMAN L. ROSEN, LEONARD M. FREEMAN
Journal: Clinical Nuclear Medicine (1980)

WEISSMANN, HEIDI S. M.D.; SUGARMAN, LEROY A. M.D.; ROSEN, NORMAN L. M.D.; FREEMAN, LEONARD M. M.D. Author Information
Re: "Troubles in Medical Academe": A Clarification
Authors: Bernard D. Davis
Journal: JAMA (1977)

To the Editor.—  In an editorial on July 26 (236:388, 1976), H. H. Hussey described my article in the New England Journal of Medicine (294:1118-1119, 1976) as a spring that ended in a dive rather than a vault. In support of this conclusion, he noted that (1) Harvard's dean had called my action irresponsible, (2) I had apologized, and (3) in the New York Times , President Cooper of the Association of American Medical Colleges had convincingly explained why my charges were not true.  On the contrary, now that the initial furor has abated, it seems clear that my message has brought into the open concerns that are widely felt, at least among those who have teaching contact with students and not simply administrative contact with symbols. It is important to recognize these concerns about standards for graduation, for we must ensure that our minority programs succeed, and the greatest threat to
Characterization of novel platelet and endothelial cell target antigens in a family with genetic susceptibility to autoimmunity
Authors: Sofia Hashemi, Elise Trudel, Peter R. Ganz, Jeanne Drouin, Roger Couture, Denis Page, M. T. Aye
Journal: American Journal of Hematology (1991)

This report describes a French Canadian family whose members exhibit a high incidence of allo- and autoantibodies to antigens present on both platelets and endothelial cells. This is correlated with various HLA specificities known to be associated with autoimmunity, such as A1, B8, DR3, and, in some cases, with clinical disorders, including nephritis, hypertension, and thrombocytopenia. Immunoblot analysis using platelet and endothelial cell lysates showed serum antibodies to a 75 kDa endothelial cell surface polypeptide and to polypeptides with apparent mass of 115 kDa and 26 kDa found on both platelets and endothelial cells. This 115 kDa internal platelet protein was also found in a variety of other cell types, such as mononuclear cells, and increased following cell activation. Monoclonal antibody immunobilization assays were used to characterize the 26 kDa polypeptide; in three of the four patients tested, an antibody to leukocyte differentiation antigen CD9 was identified. The asymptomatic child of the propositus also exhibited an autoantibody against an 80 kDa platelet protein which was sensitive to thrombin digestion, suggesting that this polypeptide may be platelet glycoprotein V. In addition, P1A1 alloantibody was identified in one sister who had given birth to a severely thrombocytopenic boy and who herself had a severe vascular rejection to a cadaver kidney 2 years prior to this study. The propositus also developed hypertensive renal disease following a pregnancy and became dialysis dependent. Thus, members of this family have developed a variety of antibodies, particularly to platelet and endothelial cell antigens. Some subjects have remained asymptomatic in spite of having autoantibodies. However, others have been seriously ill, and their immune response to these antigens is believed to have played a role in the pathogenesis of their neonatal alloimmune thrombocytopenic purpura, hypertensive renal disease, renal graft rejection, and thrombocytopenia.
Anaphylactic reactions to sunflower seed
Authors: I. G.K. Axelsson, E. Ihre, O. Zetterström
Journal: Allergy (1994)

We report on four patients sensitized to sunflower seed. Three of them developed anaphylaxis and one chronic bronchial asthma. All four patients reacted the first time sunflower seeds were ingested, and all had kept cage birds fed on sunflower seeds. Therefore, the route of sensitization was probably by inhalation of airborne sunflower seed allergens. Investigation of this type of hypersensitivity in 84 atopic patients showed that only three patients were RAST‐positive, indicating that this allergy is fairly uncommon. On the other hand, when atopic persons are exposed to cage birds, the rate of sensitization is rather high, as indicated by the fact that in this category 79% were skin prick positive and 21% were unequivocably RAST positive to sunflower seed.
VALUE OF 3D-ECHOCARDIOGRAPHY IN PATIENT SELECTION PRIOR TO IMPLANTATION OF A COREVALVE®-PROSTHESIS
Authors: Robert Schueler, Marcel Weber, Diana Momcilovic, Alexander Ghanem, Jan M. Sinning, Nikos Werner, Georg Nickenig, Christoph Hammerstingl
Journal: Journal of the American College of Cardiology (2011)
Reopening Old Divisions
Authors: David B. Resnik
Journal: The American Journal of Bioethics (2011)

Click to increase image sizeClick to decrease image size Acknowledgments This article is not subject to U.S. Copyright Law. This article is the work product of an employee or group of employees of the National Institute of Environmental Health Sciences (NIEHS), National Institutes of Health (NIH); however, the statements, opinions, or conclusions contained herein do not necessarily represent the statements, opinions, or conclusions of NIEHS, NIH or the U.S. government.
1022-103 Does Primary Angioplasty Improve the Prognosis of Patients with Diabetes and Acute Myocardial Infarction?
Authors: Gregg W. Stone, Cindy L. Grines, Kevin F. Browne, Jean Marco, Donald Rothbaum, James O’Keefe, GeDffrey O. Hartzler, Paul Overlie, Brian Donohue, Noah Chelliah, Sylvia Puchrowicz, William W. O’Neill
Journal: Journal of the American College of Cardiology (1995)
The importance of the coal tar bath in the Ingram treatment of psoriasis. Evaluation by evaporimetry and laser Doppler flowmetry
Authors: T. FRODIN, M. SKOGH, L. MOLIN
Journal: British Journal of Dermatology (1988)

The contribution of the tar component to the efficacy of the Ingram regimen in the treatment of psoriasis was assessed in 11 patients with symmetrical lesions on the upper extremities. One arm was immersed in an oil emulsion bath and the other in a coal tar bath. Whole body ultraviolet irradiation followed, and dithranol paste was applied to all lesions. Healing was assessed clinically at weekly intervals, and was found to parallel the normalization of transepidermal water loss (TEWL) as determined by evaporimetry, and the dermal blood flow as evaluated by laser Doppler flowmetry. Results obtained with coal tar baths were not significantly different from those obtained with oil emulsion. We conclude that coal tar bath additive has no advantage over oil emulsion in the Ingram regimen.
The treatment of port-wine stains with the pulsed dye laser at 600 nm
Authors: D.WIEGLEB EDSTRÖM, A.-M. ROS
Journal: British Journal of Dermatology (1997)

The standard wavelength in the treatment of port-wine stains (PWS) with the pulsed dye laser is 585 nm. In many cases, the response to therapy is not adequate despite many treatments, depending partly on vessels out of reach of the laser. Longer wavelengths penetrate deeper into the dermis, but are absorbed less by oxyhaemoglobin, and require higher fluences. In this study, 22 patients with PWS were treated with the flashlamp-pumped pulsed dye laser using two different wavelengths, 585 and 600 nm. Four adjacent sites with PWS were treated on one occasion with 585 nm, 600 nm and equal fluence, and with 1.5 and 2 times the 585 nm fluence. The test areas were examined blindly, by four evaluators, an average of 12.5 weeks later. There was significantly less lightening with 600 nm than with 585 nm (P < or = 0.001) when equal fluences were used. When 1.5 and 2 times the 585 nm fluence were applied, with 600 nm the lightening was equal to that after 585 nm. However, in individual cases (11 of 22) 600 nm showed a superior lightening of at least 20% compared to 585 nm. There was slight hyperpigmentation and hypopigmentation, but no atrophy or scarring. In conclusion, 585 nm remains the wavelength of choice in treatment of PWS with the pulsed dye laser. However, in cases that do not respond satisfactorily with 585 nm, it may be worth trying 600 nm with a fluence that is at least 1.5-2 times the 585 nm fluence.
hGH promotes megakaryocyte differentiation and exerts a complementary effect with c-Mpl ligands on thrombopoiesis
Authors: Yang Xu, Song Wang, Mingqiang Shen, Zhou Zhang, Shilei Chen, Fang Chen, Mo Chen, Dongfeng Zeng, Aiping Wang, Jinghong Zhao, Tianmin Cheng, Yongping Su, Junping Wang
Journal: Blood (2014)
Developing future surgical workforce structures: A review of post-training non-Consultant grade specialist roles and the results of a national trainee survey from the Association of Surgeons in Training
Authors: J. Shalhoub, C.E.B. Giddings, H.J.M. Ferguson, S.T. Hornby, G. Khera, J.E.F. Fitzgerald
Journal: International Journal of Surgery (2013)

The optimal workforce model for surgery has been much debated historically; in particular, whether there should be a recognised role for those successfully completing training employed as non-Consultant grade specialists. This role has been termed the ‘sub-consultant’ grade. This paper discusses historical and future career structures in surgery, draws international comparisons, and presents the results of a national trainee survey examining the post-Certificate of Completion of Training (CCT) non-consultant specialist grade. Junior doctors in surgical training (i.e. pre-CCT) were invited to participate in an electronic, 38-item, self-administered national training survey. Of 1710 questionnaires submitted, 1365 were appropriately completed and included in the analysis. Regarding the question ‘Do you feel that there is a role in the surgical workforce for a post-CCT non-consultant specialist (“sub-consultant”) grade in surgery?’, 56.0% felt there was no role, 31.1% felt there was a role and 12.8% were uncertain. Only 12.6% of respondents would consider applying for such a post, while 72.4% would not and 15.0% were uncertain. Paediatric (23.3%), general (15.7%) and neurosurgery (11.6%) were the specialties with the highest proportions of trainees prepared to consider applying for such a role. For both questions, there was a significant gender difference in responses (p < 0.0001, Chi-square test) with female trainees more likely to consider applying. Overall 50.8% of respondents felt that the introduction of a post-CCT non-consultant specialist grade would impact positively upon service provision, however, only 21.6% felt it would have a positive impact on patient care, 13.9% a positive impact on surgical training, 11.1% a positive impact on the surgical profession and just 7.9% a positive impact on their surgical career. This survey indicates that the introduction of a ‘sub-consultant’ grade for surgeons who have completed training would be unpopular, with the majority believing it would be to the detriment of both patient care and surgical training. Changes to surgical career structures must be made in the interests of patient safety and quality, and on this basis ASiT supports the continued provision of primarily Consultant-delivered care.Download : Download high-res image (101KB)Download : Download full-size image
Microfluidic Strategies for Design and Assembly of Microfibers and Nanofibers with Tissue Engineering and Regenerative Medicine Applications
Authors: Michael A. Daniele, Darryl A. Boyd, André A. Adams, Frances S. Ligler
Journal: Advanced Healthcare Materials (2014)

Fiber‐based materials provide critical capabilities for biomedical applications. Microfluidic fiber fabrication has recently emerged as a very promising route to the synthesis of polymeric fibers at the micro and nanoscale, providing fine control over fiber shape, size, chemical anisotropy, and biological activity. This Progress Report summarizes advanced microfluidic methods for the fabrication of both microscale and nanoscale fibers and illustrates how different methods are enabling new biomedical applications. Microfluidic fabrication methods and resultant materials are explained from the perspective of their microfluidic device principles, including co‐flow, cross‐flow, and flow‐shaping designs. It is then detailed how the microchannel design and flow parameters influence the variety of synthesis chemistries that can be utilized. Finally, the integration of biomaterials and microfluidic strategies is discussed to manufacture unique fiber‐based systems, including cell scaffolds, cell encapsulation, and woven tissue matrices.
Primigravida or primipara?
Authors: A. J. Bray
Journal: BMJ (1968)

SmnmTSu 317 recovered in five weeks.This and the two subsequent attacks were all treated with an intra- venous injection of 100,000 u. antitoxin, after precautions against reactions.On 19 November he had a severe recurrence of tetanus with all the classical symptoms and signs but more violent reflex spasms, which had to be con- trolled with inhalation of chloroform.It was three weeks before he could open his mouth, but he made a complete recovery.