tbuckley/cabot-search huggingface dataset:
Impact of the Media and the Internet on Oncology: Survey of Cancer Patients and Oncologists in Canada
Authors: Xueyu Chen, Lillian L. Siu
Journal: Journal of Clinical Oncology (2001)

PURPOSE: To evaluate the use of the news media and the Internet as sources of medical information by patients and oncologists in Canada and to investigate the impact on patients’ treatment decisions and the patient-doctor relationship. PATIENTS AND METHODS: During a 2-week period, 191 ambulatory patients participated in the survey. Questionnaires were also mailed to Canadian oncologists: 410 of 686 questionnaires were returned (response rate = 60%). RESULTS: Of the 191 patients, 86% wanted as much information as possible about their illness, 54% reported receiving insufficient information, 83% cited physicians as their primary information source, and 7% cited the Internet. Seventy-one percent of patients actively searched for information, and 50% used the Internet. Patients’ opinions about the balance, accuracy, and relevance of news media reports were evenly split. English as the first language, access to the Internet, and use of alternative treatments predicted a higher rate of information seeking. Most oncologists routinely pay some attention to medical news and believe that it is difficult for patients to interpret medical information in the media and on the Internet accurately. Both patients and oncologists agree that information seeking does not affect the patient-physician relationship. CONCLUSION: Information searching is common among cancer patients in Canada. It does not affect the patient-doctor relationship. The media and the Internet are powerful means of medical information dissemination. Strategic efforts are needed to improve the quality of medical news reporting by the media, and to provide guidance for patients to understand their disease and interpret such information better.
Improved survival of follicular lymphoma patients in the surveillance, epidemiology, and end-results (SEER) program
Authors: W. T. Swenson, C. F. Lynch, J. Wooldridge, V. L. Forman-Hoffman, E. Chrischilles, B. K. Link
Journal: Journal of Clinical Oncology (2004)

6578 Background: Follicular lymphomas (FL) comprise 17% of non-Hodgkin lymphoma cases in the United States. Several single- and multi-institution groups have published analyses of long-term follow-up of FL patients, yet it remains unclear whether survival patterns in FL have changed over the past twenty years. Methods: Using data provided in the National Cancer Institute's SEER program, 12,088 patients with FL were identified by ICD-O-2 diagnostic codes: grade I (9693–9696), grade II (9691–9692), grade III (9697–9698), grade NOS (9690). Observed median survival curves and proportional death hazard ratios were calculated from Cox regression analysis using SAS version 8.2. SEER*Stat 5.0 was used to calculate relative survival rates where expected survival rates were based on mortality rates for the entire U.S. population. Survival probabilities were calculated accounting for diagnosis era (1983–89, 1990–99), age at diagnosis, gender, race, and tumor grade at diagnosis. Results: Compared with FL patients diagnosed in the 1990–1999 era, those diagnosed in the 1983–1989 era had statistically elevated death hazard ratios. These findings were consistent among subsets including advanced stage (III and IV), grade I and grade III, male, female, and patients under and over age 60. Survival trends demonstrated analogous findings across eras when calculated using relative median survival rates. Conclusions: Overall survival for FL has improved over the past 20 years, perhaps related to changes in management. This improvement is noted broadly across subsets evaluated including advanced stage, divergent age groups and at extremes of grade classification. No significant financial relationships to disclose.
Incidence and clinical features of community-acquired legionellosis in hospitalized patients
Authors: B Ruf, D Schurmann, I Horbach, FJ Fehrenbach, HD Pohle
Journal: European Respiratory Journal (1989)

In a two-year prospective study of patients hospitalized because of community-acquired pneumonia, the incidence of legionellosis was found to be 3.8% (17/442 cases). After S. pneumoniae, M. pneumoniae and influenzae viruses, legionellae were the fourth most frequently identified pneumonia agents. We evaluated the clinical data from 41 cases with legionellosis, 17 diagnosed in this prospective study and 24 prior to the study. The age range of all patients (22 women, 19 men) was 24-78 yrs (median 61.3 yrs), 14 of 41 cases (34.1%) had extrapulmonary organ involvement. Twelve patients (29.3%) died. The fatality rate was 4.5% (1/22 cases) in patients treated with erythromycin, and 57.9% (11/19 cases) in patients treated with other antibiotics. Antibiotics effective in legionellosis should be added to the routine therapy of community-acquired pneumonia when this aetiology can not be excluded.
Abstract 13129: A 4q25 Variant and Cardioembolic Stroke in the Vienna Stroke Registry
Authors: May M Luke, Carmen H Tong, Joseph J Catanese, Stefan Greisenegger, James J Devlin, Christine Mannhalter
Journal: Circulation (2010)

Introduction: A single nucleotide polymorphism (SNP) on chromosome 4q25 (rs2200733) was reported to be associated with atrial fibrillation and with ischemic stroke_in particular the cardioembolic s...
Chest drain insertion and complications in a hospital in the Northwest of England
Authors: William Falconer, Andrew Disney, Simon Twite, Paul Stockton
Journal: European Respiratory Journal (2013)

Introduction 

Intercostal chest drain insertion is a common yet potentially hazardous procedure within Respiratory practice. In 2008 the UK National Patient Safety Agency reported deaths and serious harm related to their use. Documentation of written consent and pleural ultrasound prior to draining fluid were specific areas highlighted for improvement.

Aims 

We aimed to establish which clinicians insert chest drains, if written consent is being obtained, if pleural ultrasound is being used and the complication rates within our hospital.

Methodology 

A retrospective analysis of 76 clinical records of patients who had chest drain procedures between April 2011 - December 2012 was conducted. Data was collected regarding consent, ultrasound imaging, insertion of drain and complications.

Results 

Indications for chest drain insertion: pleural effusion 53%, spontaneous pneumothorax 29%, empyema 5%, traumatic haemothorax 5%, traumatic pneumothorax 5% and post-aspiration pneumothorax 1%.

There was evidence of documented written consent in 39%, no written evidence in 42% and documented emergency reason for no written consent in 18%.

Senior House Officers inserted 49% of drains, Registrars 37%, Consultants 9%, House Officers 3%.

Thoracic ultrasound was performed in 78% of cases requiring fluid drainage. 78% had Seldinger drain insertion, 13% surgical drains and 9% not documented.

41% of drains developed complications. Drain falling out was the commonest in 13%.

Conclusions 

A significant number of drains were inserted without written consent (42%) or prior ultrasound (28%). 41% of drains were associated with complications although none were life threatening. We plan to arrange further training amongst junior doctors.
Retinoid Inhibition of Experimental Lingual Carcinogenesis: Ultrastructural Observations&lt;xref ref-type="fn" rid="fn2"&gt;2&lt;/xref&gt;, &lt;xref ref-type="fn" rid="fn3"&gt;3&lt;/xref&gt;
Authors: G Shklar, E Flynn, G Szabo, P Marefat
Journal: JNCI Journal of the National Cancer Institute (1980)

Journal Article Retinoid Inhibition of Experimental Lingual Carcinogenesis: Ultrastructural Observations, Get access Gerald Shklar, D.D.S., Gerald Shklar, D.D.S. Search for other works by this author on: Oxford Academic PubMed Google Scholar Evelyn Flynn, B.A., Evelyn Flynn, B.A. Search for other works by this author on: Oxford Academic PubMed Google Scholar George Szabo, Ph.D., George Szabo, Ph.D. Search for other works by this author on: Oxford Academic PubMed Google Scholar Parshang Marefat, D.D.S., D.M.Sc. Parshang Marefat, D.D.S., D.M.Sc. Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 65, Issue 6, December 1980, Pages 1307–1316, https://doi.org/10.1093/jnci/65.6.1307 Published: 01 December 1980 Article history Received: 24 March 1980 Accepted: 07 July 1980 Published: 01 December 1980
The Respiratory Epithelium. I. Human Bronchus&lt;xref ref-type="fn" rid="FN2"&gt;2&lt;/xref&gt;&lt;xref ref-type="fn" rid="FN3"&gt;3&lt;/xref&gt;
Authors: Elizabeth M. McDowell, Lucy A. Barrett, Fred Glavin, Curtis C. Harris, Benjamin F. Trump
Journal: JNCI Journal of the National Cancer Institute (1978)

Six morphologic cell types comprise the human bronchial epithelium: basal cells that do not reach the bronchial lumen, neurosecretory cells (Kulchitsky's cells, K-cells, or small granule cells) that rarely reach the lumen, and indifferent cells, mucous cells [small mucous granule cells (SMGC) and mucous goblet cells], ciliated cells, and ciliated-mucous cells that do reach the lumen. Ciliated-mucous cells bearing fully developed cilia and containing mucous granules are seen only occasionally. Three of the cell types that reach the lumen are microvillus covered and do not bear cilia. The microvillus-covered nonciliated cells are: 1) neurosecretory cells, 2) indifferent cells, and 3) mucous cells. Neurosecretory cells contain characteristic dense core granules. Such cells rarely reach the lumen. Indifferent cells are rarely seen. They have a pale cytoplasm and show no evidence of either ciliary or mucous differentiation. Similar cells are observed showing early signs of either ciliary or mucous differentiation or even both types of differentiation in the same cell. Mucous cells comprise the vast majority of microvillus-covered cells. They present either as SMGC with a few small mucous granules or as goblet cells, filled with mucus. These columnar cells are characterized ultrastructurally by dense cytoplasm and a well-developed endoplasmic reticulum and Golgi apparatus. The microvilli are coated with a glycocalyx that binds colloidal iron more avidly than that of either cilia or microvilli of ciliated cells. Possible interrelationships between the different cell types in normal epithelium are discussed.
Value-Based Insurance Design: Aligning Incentives, Benefits, and Evidence in Oncology
Authors: Jonas A. de Souza, Mark J. Ratain, A. Mark Fendrick
Journal: Journal of the National Comprehensive Cancer Network (2012)

When everyone is required to pay the same out-of-pocket amount for oncology services for which benefits depend on patient characteristics and clinical indication, there is enormous potential for both under- and overutilization. Unlike most current health plan designs, the value-based insurance design (V-BID) explicitly acknowledges and responds to patient heterogeneity across the entire continuum of cancer care. By adding "clinical nuance" to benefit design, V-BID encourages the use of services when the clinical benefits exceed the cost, and likewise discourages the use of services when the benefits do not justify the expenditure. This manuscript further describes the concept of V-BID, creates a framework for its development in oncology, and outlines how this concept aligns with ongoing research, care delivery, and payment reform initiatives.
Analysis of Error Profiles Occurring during the OSLER Test
Authors: Stephanie Mazza, Jean-Louis Pepin, Chrystele Deschaux, Bernadette Naegele, Patrick Levy
Journal: American Journal of Respiratory and Critical Care Medicine (2002)

The OSLER test represents a simple alternative to the maintenance of wakefulness test. Standard analysis of OSLER test results yields a mean sleep latency (MSL). The aim of this study was to use both MSL and errors (nonresponses to stimulations) to characterize daytime sleepiness in apneic patients. OSLER test results at 9:00 a.m., 11:00 a.m. and 1:30 p.m. were compared in 27 obstructive sleep apnea syndrome patients (50.4 ± 10.4 years; apnea–hypopnea index: 43.05 ± 25.08) and 20 control subjects (C). Not only did obstructive sleep apnea syndrome patients demonstrate earlier sleep onset than control subjects (MSL: 1,788 seconds ± 511 versus 2,335 seconds ± 139, p < 0.001), but they also spent a greater percentage of time making errors than control subjects (5.4% ± 4.7 of total test time versus 0.4% ± 0.4, p < 0.001) with specific error profiles (high prevalence of three to six consecutive errors). When error profile analysis was added to standard sleep latency assessment, up to 40% of patients with normal sleep latency were exhibiting abnormal fluctuation in vigilance. A single 9:00 a.m. OSLER session appeared as sensitive as three consecutive sessions in its use as a means of identifying patients with significant daytime sleepiness. On the other hand, the 1:30 p.m. OSLER test session was least specific to distinguish apneic subjects from normal subjects, suggesting that the OSLER test can identify the afternoon peak in physiologic somnolence.
The trends of tuberculosis in Kosovo in the post war period, (2001-2010)
Authors: Bahri Tigani
Journal: European Respiratory Journal (2012)

Objective : To analyze the trends of Tuberculosis in Kosovo during the first decade of the post war period, (2001-2010).   Methods : The TB National Reports of the years 2001-2010 has been used and different TB indicators has been analyzed and measured.   Results : Number of TB cases for the period 2001-2010 decreased from 1674 (Year 2001) to 920 (Year 2010). TB Notification Rate/100 000 decreased from 78.2 in year 2001 to 43.7 in year 2010, which presents median annual decrease of 3.45%.  Number of new sputum smear positive cases during the period 2001-2010 decreased from 461 in year 2001 to 287 in year 2010. Notification rate/100 000 for New sputum smear positive cases in year 2001 was 21.5 and decreased to 13.6 in year 2010.  Bacteriological confirmation (only smear) of TB diagnosis within the pulmonary cases has increased from 41.8% to 50 %,(2001-2010).  Extra pulmonary TB has increased from 19% (year 2001) to 33% (year 2010).  Proportion of relapses (SS+) among all TB cases decreased from 6.3% (2001) to 3.2% (2010).  Proportion of children under 15 years old among all TB cases decreased from 6.5% to 3.2 %.  The pick of TB cases notified by age-groups was in the age groups 15-34 that is expected due to the very young population of Kosovo, (more than 50 % of Kosovo population is under 20 years.  The specific incidence by age groups shows that the highest number of TB cases is in the age group > 65 years.  M/F proportion for all TB cases in all age groups is 1,0.  M/F proportion for New smear positive cases is 1.27.   Conclusion : The trends of tuberculosis in Kosovo during the post war period (2001-2010), give the good perspective of TB situation in the country.
Dual antitumoral potency of EG5 siRNA nanoplexes armed with cytotoxic bifunctional glutamyl-methotrexate targeting ligand
Authors: Dian-Jang Lee, Eva Kessel, Daniel Edinger, Dongsheng He, Philipp M. Klein, Lena Voith von Voithenberg, Don C. Lamb, Ulrich Lächelt, Taavi Lehto, Ernst Wagner
Journal: Biomaterials (2015)
A Randomized, Double‐Blind, Placebo‐Controlled, Twelve‐Week, Dose‐Ranging Study of Decernotinib, an Oral Selective JAK‐3 Inhibitor, as Monotherapy in Patients With Active Rheumatoid Arthritis
Authors: Roy M. Fleischmann, Nemanja S. Damjanov, Alan J. Kivitz, Anna Legedza, Thomas Hoock, Nils Kinnman
Journal: Arthritis & Rheumatology (2014)

To assess the efficacy and safety of oral decernotinib (VX-509; Vertex Pharmaceuticals) monotherapy in a 12-week, randomized, double-blind, placebo-controlled, dose-ranging study of patients with rheumatoid arthritis (RA).Two hundred four adults with active RA who had been unsuccessfully treated with ≥1 disease-modifying antirheumatic drug were administered placebo tablets or decernotinib twice a day at dosages of 25 mg, 50 mg, 100 mg, or 150 mg. Primary measures of efficacy at week 12 were the response rate according to the American College of Rheumatology 20% improvement criteria (ACR20) and mean change from baseline in the Disease Activity Score in 28 joints using the C-reactive protein level (DAS28-CRP).At week 12, the ACR20 response rates were 39.0%, 61.0%, 65.0%, and 65.9% in the 25-mg, 50-mg, 100-mg, and 150-mg groups, respectively, and were significantly higher in the 50-mg group (P = 0.007) and the 100-mg and 150-mg groups (P = 0.002) as compared to the response rates in the placebo group (29.3%). The mean change from baseline in DAS28-CRP was greater in the 50-mg, 100-mg, and 150-mg groups as compared to the placebo group (P < 0.001). Decernotinib treatment resulted in higher ACR50 and ACR70 response rates, more patients with DAS28-CRP scores <2.6, and improvements in the Health Assessment Questionnaire disability index as compared to placebo. The most common adverse events in any decernotinib group were nausea (6.1%), headache (4.3%), an increase in levels of alanine aminotransferase (4.3%), and hypercholesterolemia (3.7%). In the groups receiving decernotinib, there was an increased risk of infections and increased liver transaminase levels.Decernotinib was efficacious in improving clinical signs and symptoms of RA at week 12 at dosages of 50-150 mg twice a day. Infections and increases in liver transaminase and lipid levels were noted as potential safety signals.
Breastfeeding and Childhood Leukemia Incidence
Authors: Hilary S. Gammill, Filippo Milano, J. Lee Nelson
Journal: JAMA Pediatrics (2015)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Pediatrics HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Pediatrics journal
Cancer Incidence and Mortality Trends Among Whites in the United States, 1947–84
Authors: S S Devesa, D T Silverman, J L Young, E S Pollack, C C Brown, J W Horm, C L Percy, M H Myers, F W McKay, J F Fraumeni
Journal: JNCI Journal of the National Cancer Institute (1987)

Journal Article Cancer Incidence and Mortality Trends Among Whites in the United States, 1947–84 Get access Susan S. Devesa, Ph.D., Susan S. Devesa, Ph.D. Search for other works by this author on: Oxford Academic PubMed Google Scholar Debra T. Silverman, Sc.D., Debra T. Silverman, Sc.D. Search for other works by this author on: Oxford Academic PubMed Google Scholar John L. Young, Jr., Dr.P.H., John L. Young, Jr., Dr.P.H. Search for other works by this author on: Oxford Academic PubMed Google Scholar Earl S. Pollack, Sc.D., Earl S. Pollack, Sc.D. Search for other works by this author on: Oxford Academic PubMed Google Scholar Charles C. Brown, Ph.D., Charles C. Brown, Ph.D. Search for other works by this author on: Oxford Academic PubMed Google Scholar John W. Horm, M.Sc, John W. Horm, M.Sc Search for other works by this author on: Oxford Academic PubMed Google Scholar Constance L. Percy, M.S., Constance L. Percy, M.S. Search for other works by this author on: Oxford Academic PubMed Google Scholar Max H. Myers, Ph.D., Max H. Myers, Ph.D. Search for other works by this author on: Oxford Academic PubMed Google Scholar Frank W. McKay, Frank W. McKay Search for other works by this author on: Oxford Academic PubMed Google Scholar Joseph F. Fraumeni, Jr., M.D. Joseph F. Fraumeni, Jr., M.D. Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 79, Issue 4, October 1987, Pages 701–770, https://doi.org/10.1093/jnci/79.4.701 Published: 01 October 1987 Article history Received: 13 May 1987 Accepted: 21 May 1987 Published: 01 October 1987
Primary Cutaneous T-Cell Lymphoma: Review and Current Concepts
Authors: Richard S. Siegel, Tomi Pandolfino, Joan Guitart, Steven Rosen, Timothy M. Kuzel
Journal: Journal of Clinical Oncology (2000)

Primary cutaneous T-cell lymphomas (CTCLs) encompass a wide variety of lymphomas that are characterized by the localization of the malignant lymphocytes to the skin at presentation. Advances in molecular biologic techniques, including immunophenotyping and gene rearrangement studies to determine clonality, have led to more frequent diagnosis of CTCL as well as more consistent subclassification of these entities. However, there continues to be confusion in the classification, prognosis, and management of patients with CTCL. The purpose of this review is to present a summary of the diagnosis, prognosis, and treatment of CTCL, with specific emphasis on mycosis fungoides (MF) and Sézary syndrome (SS). We also present a detailed discussion of the entities that make up the differential diagnosis of CTCL.We reviewed the medical literature on CTCL and other diseases that make up the differential diagnosis of CTCL.MF and SS are the most common forms of CTCL. The etiology of this disease is still unknown. Patients may go for months to years with skin abnormalities before being diagnosed. MF/SS is an indolent disease and patients with T1 disease have a normal life expectancy. Patients who undergo transformation to large-cell lymphoma (8% to 23% of patients) have a poor prognosis, with mean survival ranging from 2 to 19 months. Treatment for MF/SS continues to be palliative. There are many new therapies that are currently being investigated in clinical trials, and the DAB(389)IL-2 fusion protein was recently approved for the treatment of refractory MF/SS.
Respiratory symptoms, daytime sleepiness and quality of life - An epidemiological study on general populations in Iceland and Sweden
Authors: Bryndis Benediktsdottir, Christer Jansson, Eva Lindberg, Erna Sif Arnardottir, Thorarinn Gislason
Journal: European Respiratory Journal (2012)

Objective:  This prevalence of excessive daytime sleepiness (EDS) and the association of EDS with respiratory symptoms and large variety of health variables was investigated in two well characterized random samples from the general population.   Methods:  Adults aged >40 and living in Reykjavik, Iceland (n=939) and Uppsala, Sweden (n=998), were invited (www.boldstudy.org). Response rates 81, 1% and 62, 2%. In addition, the participants were asked to answer: The Epworth Sleepiness Scale (ESS), Short Form-12 and standardised questions about sleep and health, diabetes and hypertension,   Results:  In Reykjavik mean (+/- SD) ESS was 6.0 +/- 3.9, compared to 6.1+/- 3.9 in Uppsala. The prevalence of EDS, defined as ESS scores >10, were 18.5% in Uppsala and 18.4% in Reykjavik. EDS was more common among men than women and was more prevalent in age groups    Conclusion:  Excessive daytime sleepiness is a common complaint in the general population both in Iceland and Sweden. It9s more common among men than women, among those who snore and have apneas. EDS is also related to respiratory symptoms, allergy and decreased mental quality of live.