tbuckley/cabot-search huggingface dataset:
Relationship Between Na <sup>+</sup> -Ca <sup>2+</sup> –Exchanger Protein Levels and Diastolic Function of Failing Human Myocardium
Authors: Gerd Hasenfuss, Wolfgang Schillinger, Stephan E. Lehnart, Michael Preuss, Burkert Pieske, Lars S. Maier, Jürgen Prestle, Kazutomo Minami, Hanjörg Just
Journal: Circulation (1999)

Background —In the failing human heart, sarcoplasmic reticulum (SR) calcium handling is impaired, and therefore, calcium elimination and diastolic function may depend on the expression of sarcolemmal Na + -Ca 2+ exchanger. Methods and Results —Force-frequency relations were studied in ventricular muscle strip preparations from failing human hearts (n=29). Protein levels of Na + -Ca 2+ exchanger and SR Ca 2+ -ATPase were measured in the same hearts. Hearts were divided into 3 groups by discriminant analysis according to the behavior of diastolic function when stimulation rate of muscle strips was increased from 30 to 180 min −1 . At 180 compared with 30 min −1 , diastolic force was increased by 160%, maximum rate of force decline was decreased by 46%, and relaxation time was unchanged in group III. In contrast, in group I, diastolic force and maximum rate of force decline did not change, and relaxation time decreased by 20%. Na + -Ca 2+ exchanger was 66% higher in group I than in group III. Na + -Ca 2+ exchanger was inversely correlated with the frequency-dependent rise of diastolic force when stimulation rate was increased ( r =−0.74; P &lt;0.001). Compared with nonfailing human hearts (n=6), SR Ca 2+ -ATPase was decreased and Na + -Ca 2+ exchanger unchanged in group III, whereas Na + -Ca 2+ exchanger was increased and SR Ca 2+ -ATPase unchanged in group I. Results with group II hearts were between those of group I and group III hearts. Conclusions —By discriminating failing human hearts according to their diastolic function, we identified different phenotypes. Disturbed diastolic function occurs in hearts with decreased SR Ca 2+ -ATPase and unchanged Na + -Ca 2+ exchanger, whereas increased expression of the Na + -Ca 2+ exchanger is associated with preserved diastolic function.
Withdrawal of Diazepam
Authors: David Haskell
Journal: JAMA (1975)

<h3>To the Editor.—</h3> Several letters within the past year have expressed concern about the overprescription of diazepam (229:521, 1974; 230:375, 1974). Recent clinical experience has convinced me that this concern is justified. The manufacturers' literature warns of physical addiction to diazepam or other benzodiazepines, mainly with excessive doses. However, I have seen several patients experiencing barbiturate-type withdrawal symptoms after four to six months of diazepam therapy in doses as low as 15 mg/day. Symptoms such as tremors, agitation, fearfulness, stomach cramps, and sweating made patients extremely uncomfortable, but dangerous reactions, such as convulsions, did not occur. All of these patients had been admitted to a psychiatric hospital for depression. They were generally reluctant to stop using diazepam, but when the symptoms subsided after two to four weeks, they were usually happy to be free of medication. (Interestingly, these patients tolerated tricyclic antidepressants poorly.) The possibility of physical addiction to nonexcessive
Study to begin on whether aspirin can delay senile cataract formation
Authors: Elizabeth Rasche González
Journal: JAMA (1980)

A report that aspirin may slow the progression of senile cataracts caused much excitement at the recent American Academy of Ophthalmology meeting in Chicago. In an exhibit presented at that meeting, Edward Cotlier, MD, professor of ophthalmology at Yale University School of Medicine, New Haven, Conn, summarized several retrospective studies suggesting that salicylate may retard cataract formation. The probable mechanism is, at least in part, the reduction of plasma tryptophan levels. A prospective study, which will test this and perhaps other hypotheses about the effect of aspirin on senile cataracts, will begin soon. Cotlier and associates previously demonstrated binding of tryptophan or its metabolite kynurenine to lens protein in human senile cataracts and showed that this was associated with elevated levels of the amino acid in patients with cataracts as opposed to patients with aphakia and clear lenses (<i>Lancet</i>1980;1:607). In their latest report, they presented data showing that
Congestive Gastropathy and Antral Varices: Is there an Association?
Authors: E. Eleftheriadis, K. Kotzampassi, E. Tzartinoglou, A. Alvanou, H. Aletras
Journal: Endoscopy (1989)

Gastric mucosal lesions are frequently observed during endoscopy in cirrhotics, but only recently has attention been paid to the gastric mucosal vessels themselves as the cause of such lesions. The presence - observed during endoscopy - of areas of erythema outlined by a yellow mosaic-like network, and the existence - ascertained by histology - of focal ectasia of mucosal vessels are termed “congestive gastropathy”.
Abstract P4-06-18: Targeting basal-like breast cancer through downstream effectors of oncogene cooperation
Authors: HR McMurray, EA Walters, DM Heyer, PV Candelaria, S Wang, VA Grose, JR Llop, Y Zhang
Journal: Cancer Research (2012)

Abstract Basal-like breast cancer is a highly aggressive and lethal form of cancer, not amenable to treatment by molecularly targeted agents or conventional chemotherapy effective against other forms of breast cancer. Thus, discovery of novel intervention targets regulating tumorigenesis in basal-like breast cancer cells is critical. The success of molecularly targeted therapies against some forms of cancer has led to a search for additional cancer cell-specific targets that will permit effective tumor inhibition with minimal damage to normal cells. These efforts are largely focused on identification of novel oncogenes and tumor suppressors by genome sequencing or synthetic lethalities found via genome-wide RNAi screens. We employ a novel approach to identify cancer cell vulnerabilities among genes disregulated downstream of cooperating oncogenic mutations, which drive malignant transformation in large part through synergistic modulation of non-mutated downstream effector genes, the ‘cooperation response genes’ (CRGs) [McMurray et al., Nature, 19 June 2008]. After assessing how common was CRG disregulation in different epithelial cancers, via comparative genomic analysis of CRG expression patterns in tumor vs. normal tissue, we found that 34 CRGs (∼35%) were significantly disregulated in breast cancer. Because of the need for novel intervention targets in basal-like breast cancer, we focused our functional analysis there. We have tested a subset of CRGs disregulated in breast tumors for their contribution to malignancy in basal-like breast cancer cells, re-setting CRG levels toward normal cell levels by stable cDNA expression or shRNA-mediated knock-down and testing tumor formation capacity of perturbed cells. Our studies reveal that CRGs play an essential role in controlling tumor formation of basal-like breast cancer cells, with significant reductions in tumor volume, and in some cases reduced tumor incidence, upon CRG modulation. Disruption of cell behavior appears to be limited to cancer cells, as non-transformed mammary cells harboring analogous perturbations retain capacity to form acinar structures in 3D culture. Several FDA approved pharmacological agents, identified to reverse the CRG expression pattern, display inhibitory effects on basal-like breast cancer cell lines, with minimal effects on non-transformed cells. CRGs thus represent cancer cell-specific vulnerabilities in basal-like breast cancer, providing novel and unexpected opportunities for intervention against this difficult-to-target disease. Citation Information: Cancer Res 2012;72(24 Suppl):Abstract nr P4-06-18.
Hysterectomy can be performed on woman with schizophrenia against her will, judge rules
Authors: C. Dyer
Journal: BMJ (2012)

A High Court judge in London has given doctors the go ahead to perform a risky but potentially lifesaving hysterectomy on a woman with cancer of the uterus who denied that she had the disease.

Mr Justice Holman ruled that it would be lawful for an unnamed NHS trust in the south of England to carry out the operation on the 61 year old woman with schizophrenia, who lacked the mental capacity to make an informed decision for herself.

The judge, sitting in the Court of Protection in …
Sanitary Condition of Atlantic City.
Authors: W. Blair Stewart
Journal: JAMA (1900)

Atlantic City, N. J., Oct. 26, 1900. <h3>To the Editor:</h3> —"The sanitary condition of Atlantic City at the present time is said to be bad, and this is especially due to the defective sewerage system and the lack of attention from the board of health."The Journal, page 760. This unfortunate misrepresentation of the sanitary condition of Atlantic City is evidently founded, as it says, on hearsay and not on facts and vital statistics. When Atlantic City has just closed the healthiest season in the history of the resort it is unfair to allow this statement to go unchallenged. All contagious and infectious diseases must be reported to the board of health immediately on their diagnosis, under heavy penalty. Houses are not placarded, but are properly quarantined when occasion demands. No epidemics of any kind have occurred during the past year, nor in a number of years. The sewerage system
Factors Influencing Pulmonary Hypertensive Response to 5-Hydroxytryptamine
Authors: Jacques J. Duteil, Domingo M. Aviado
Journal: Circulation Research (1962)

The pulmonary hypertensive response to 5-HT in the dog heart-lung preparation is largely due to pulmonary vasoconstriction. There is an unexpected fall in aortic blood flow but no rise in left atrial pressure. In intact dogs the pulmonary hypertensive response is accompanied by an increase in pulmonary blood flow which is in turn partly reduced by upper thoracic sympathectomy. It is suggested that the rise in pulmonary blood flow is partly a sympathetic reflex initiated by pulmonary vasoconstriction by 5-HT.
IMPACT OF SHORT- VERSUS LONG-TERM DAPT IN PATIENTS WITH DIABETES MELLITUS UNDERGOING PERCUTANEOUS INTERVENTION WITH ENDEAVOR ZOTAROLIMUS-ELUTING STENTS – A SUBANALYSIS OF THE LARGE, PROSPECTIVE, RANDOMIZED, MULTICENTER OPTIMIZE TRIAL
Authors: Fausto Feres, Ricardo Costa, Deepak Bhatt, Joao De Paula, Roberto Botelho, J. Antônio Marin-Neto, Sérgio Berti, Pablo Teixeirense, Rone Padilha, Rogério Sarmento-Leite, Adrian Korman, Andres Sanchez, Aurea Chaves, Andrea Abizaid, Alexandre Abizaid
Journal: Journal of the American College of Cardiology (2014)
Ethical Implications of Professional Competency
Authors: Adolph R. Berger
Journal: JAMA (1967)

There has been a great deal of publicity in the lay press in recent months about so-called incompetence of physicians in the United States. Most of these tirades have been written by obviously prejudiced and, indeed, often misinformed writers. It is probable, however, that this unfortunate publicity may result in adverse responses which could affect the relationship between physician and patient or the physician and the hospital chaplain. I recognize that the medical profession is doing a great deal in the form of postgraduate education, but I would appreciate your opinion of the fundamental aspects of professional competency regarding the ethical responsibilities of the physician. Does the physician's professional competency really enhance the cooperation between physician and clergyman?
Primary Testicular Mumps.
Authors: D. L. Burnett
Journal: JAMA (1899)

So. Royalton, Vt., Oct. 17, 1899. <h3>To the Editor:</h3> —I was much interested in Dr. Landon B. Edwards' article in theJournal, October 14, on the above subject. One similar case occurred in my practice several years ago, in a carpenter, a married man, of excellent habits. I was treating several cases of mumps in his family at the time. He was at work on a building across the street from my office and came in saying that his testicles were paining him, and on examination I found they were both swollen and tender. The next day there was an increase of swelling, pain, tenderness, and a rise in temperature. This continued for two or three days more, when a very decided parotiditis occurred. The testicles did not become atrophied and I have since attended his wife in a confinement. For several years I have closely watched literature and society
U-Shaped Relationship of Blood Glucose With Adverse Outcomes Among Patients With ST-Segment Elevation Myocardial Infarction
Authors: Duane S. Pinto, Adam H. Skolnick, Ajay J. Kirtane, Sabina A. Murphy, Hal V. Barron, Robert P. Giugliano, Christopher P. Cannon, Eugene Braunwald, C. Michael Gibson
Journal: Journal of the American College of Cardiology (2005)
Alexithymic Features of the Patients with Chronic Pancreatitis
Authors: Y. Nakai, M. Sugita, T. Nakagawa, T. Araki, Y. Ikemi
Journal: Psychotherapy and Psychosomatics (1979)

61 patients suffering from chronic pancreatitis were studied in order to clarify the psychosomatic aspects of this disease. They were classified into 5 types, out of which 3 types were examined in detail according to their personality traits and life habits. It was found that the mind-body relationship took the primary form in the psychosomatic and neurotic types, while in the organic type it took the secondary form such as distorted life habits. This finding indicated that the distortion in the personality structure and that of life habits were closely interrelated. The authors also discussed the clinical features of chronic pancreatitis from the standpoint of alexithymia. The patients with the organic type were most alexithymic, which were followed by the psychosomatic type. It was learned that alexithymic problems were reflected in the patients' life habits.
A Lecture on Certain Phenomena of Hysteria Major
Authors: G. Sigerson
Journal: BMJ (1878)

PROFESSOR CIIARCOT, addressing his audience, said :-You will not be surprised if your attention be again occupied by the study of the great neurosis which I have termed hysteria major.This, it should be remarked, is not the common and mild type of hysteria usually met with elsewhere and in private practice; but it is that nmost common in this hospital, especially under the form of hystero-epilepsy.In the first place, we find that, though the hysterical fit is transient, there may be permanent accidents left as marks of its presence; among these
SPONTANEOUS HAEMATOMA OF THE RECTUS ABDOMINIS MUSCLE
Authors: P. Malpas
Journal: BMJ (1930)

JO_U_A&is the fact that oxygen is far more gellerally used Inow than it used to be.Formerly a cylinder stood in a remote corner, anid was onily resort.dto, soinewlhat shamefacedly, wheni the patient was either lultie or moribund.Now it stanids at the a 'aesthetist's elbow anid is in constanit use, either n a gas and oxygeni miachinle or as the motive power' for a Sliipway or in conniicxioni with ant or-diniary closed or openi rmethod.This appears to fit in historically, but it is puriely speculative.It is put forwaird because all the otlher thecories appear to be faulty oni exarminlatioll.Conclutsion.1in viev of the lack of real klmow-lglt2fe it wouil(d be ami exctIleloit plan if all eases, fatal oi Inot, w-Cre niotifiable anid lmll(leiwcnlt a fiill inivestigatioln on the linlles suggested by thle alhove titeorics.The coniditioii is so mare that im(lidviduals calinot solve the Problem.I regret thalt thme oxygen useed in niO own-i case was iiot examinedl, buit the possibility of this being at fault onily occurred to miie after collectilng, examining, and rejecting tle published explanations.It wouldl be wortl whllile inivestigatinig this poiiit ini any fuiturlie cases.
Angiogenesis Monitored by Perfusion with a Space-Filling Microbead Suspension
Authors: Matthew L. Springer, Tze Kin Ip, Helen M. Blau
Journal: Molecular Therapy (2000)

Numerous laboratories are focusing efforts on delivering gene products to induce or prevent the development of new blood vessels in adults, with the hope of rescuing ischemic tissues, circumventing cardiac bypass surgery, or inhibiting tumor growth. Current approaches to the assessment of vascular continuity involve the introduction of either dyes or fluorescent microspheres to track blood flow. However, dyes and dextrans are subject to leakage when vessels are hyperpermeable, a situation that may occur in studies of tumor vasculature and during efforts to stimulate therapeutic angiogenesis. Furthermore, the microspheres that are used for flow studies do not allow a comprehensive visual analysis of vascular continuity. Here we report a method for the visual assessment of microvascular continuity in mouse muscle under circumstances in which vessels are leaky. The approach involves perfusion of the vasculature with fluorescent beads that are much smaller than those used for flow studies. The suspension behaves like a fluid and completely fills the vessels, yet the beads do not leak from VEGF-permeablized capillaries and remain localized in histological sections. Use of beads with the proper fluorescence emission wavelengths allows immunofluorescent colocalization with vessel-specific markers. We compare this improved method with other methods for tracking vascular continuity involving dextrans and larger beads. This approach should aid in the dynamic study of tumor angiogenesis and the evaluation of efforts to deliver angiogenic factors.
School soft drink intervention study
Authors: Simone A French, Peter J Hannan, Mary Story
Journal: BMJ (2004)

Too good to be true? 

The paper by James et al in this issue of BMJ USA (p 410) describes the results of a five-session, classroom-based educational curriculum on changes in body mass index (BMI), over-weight prevalence, and carbonated beverage consumption among 7- to 11-year-old children in six schools. After one year, a significant difference between intervention and control groups was observed for change in prevalence of overweight. Total carbonated beverage intake did not significantly change among children in the control classrooms, but a significant decrease was observed among children in the intervention classrooms.

No single study can provide irrefutable evidence linking soft drink consumption and obesity among children. While this paper provides some intriguing findings that warrant further exploration in follow-up studies, several notable methodological limitations cloud the interpretation of the findings and prevent firm conclusions from being drawn.

Conceptually, perhaps the most important limitation is the absence of a mediational analysis that specifically links changes in soft drink consumption to changes in obesity prevalence.1 The …
The Prospective, Observational, Multicenter, Major Trauma Transfusion (PROMMTT) Study
Authors: John B. Holcomb, Deborah J. del Junco, Erin E. Fox, Charles E. Wade, Mitchell J. Cohen, Martin A. Schreiber, Louis H. Alarcon, Yu Bai, Karen J. Brasel, Eileen M. Bulger, Bryan A. Cotton, Nena Matijevic, Peter Muskat, John G. Myers, Herb A. Phelan, Christopher E. White, Jiajie Zhang, Mohammad H. Rahbar, for the PROMMTT Study Group
Journal: JAMA Surgery (2012)

To relate in-hospital mortality to early transfusion of plasma and/or platelets and to time-varying plasma:red blood cell (RBC) and platelet:RBC ratios.Prospective cohort study documenting the timing of transfusions during active resuscitation and patient outcomes. Data were analyzed using time-dependent proportional hazards models.Ten US level I trauma centers.Adult trauma patients surviving for 30 minutes after admission who received a transfusion of at least 1 unit of RBCs within 6 hours of admission (n = 1245, the original study group) and at least 3 total units (of RBCs, plasma, or platelets) within 24 hours (n = 905, the analysis group).In-hospital mortality.Plasma:RBC and platelet:RBC ratios were not constant during the first 24 hours (P < .001 for both). In a multivariable time-dependent Cox model, increased ratios of plasma:RBCs (adjusted hazard ratio = 0.31; 95% CI, 0.16-0.58) and platelets:RBCs (adjusted hazard ratio = 0.55; 95% CI, 0.31-0.98) were independently associated with decreased 6-hour mortality, when hemorrhagic death predominated. In the first 6 hours, patients with ratios less than 1:2 were 3 to 4 times more likely to die than patients with ratios of 1:1 or higher. After 24 hours, plasma and platelet ratios were unassociated with mortality, when competing risks from nonhemorrhagic causes prevailed.Higher plasma and platelet ratios early in resuscitation were associated with decreased mortality in patients who received transfusions of at least 3 units of blood products during the first 24 hours after admission. Among survivors at 24 hours, the subsequent risk of death by day 30 was not associated with plasma or platelet ratios.
MYXOEDEMA CIRCUMSCRIPTUM THYROTOXICUM
Authors: E. LIPMAN COHEN.
Journal: British Journal of Dermatology (1946)

Journal Article MYXOEDEMA CIRCUMSCRIPTUM THYROTOXICUM Get access E. LIPMAN COHEN. E. LIPMAN COHEN. Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology and Syphilis, Volume 58, Issue 7-8, 1 July 1946, Pages 173–182, https://doi.org/10.1111/j.1365-2133.1946.tb11234.x Published: 01 July 1946
THE FUTURE OF THE MEDICAL MAN
Authors: JOHN GEORGE ADAMI
Journal: JAMA (1913)

<h3>Gentlemen of the Graduating Class:</h3> Need I tell you how I appreciate the honor that has been conferred on me by your dean and the medical faculty of Rush Medical College by asking me to address you this afternoon at this, the culminating moment of your university career? But let me confess to you that with the honor comes the sense of heavy responsibility. From him to whom much is given much is also asked. Time and again in the years that are to come, this graduation ceremony will recall itself to the minds of each one of you as marking an epoch. It would be well could I utter words which should impress themselves in such a way that they remain with you as part and parcel of the event, words memorable tor themselves as well as of the occasion; but if the utterance of such words is given
Current Controversies in Vaccination
Authors: Yvonne A. Maldonado
Journal: JAMA (2002)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal