tbuckley/cabot-search huggingface dataset:
Abstract P094: Association of Body Mass Index (BMI) with Abnormalities of Cardiac Structure and Function: The Atherosclerosis Risk in Communities (ARIC) Study
Authors: Natalie Bello, Amil M Shah, Angela B Santos, Gabriela Querejeta Roca, Orly Vardeny, Brian Claggett, David Aguilar, Aaron R Folsom, Kenneth R Butler, Dalane W Kitzman, Josef Coresh, Scott D Solomon
Journal: Circulation (2014)

Aim: Obesity is a prevalent condition associated with a heightened risk of cardiovascular disease. We assessed the association between normal weight, overweight, and obesity defined by body mass index (BMI) and cardiac structure and function in a sample of 4,845 older adults, aged 66-90 years. Methods: We performed a cross-sectional analysis of ARIC cohort participants during visit 5 (2011-2013), excluding those with prevalent coronary heart disease, heart failure, or prior myocardial infarction, or race other than black or white. The sample was grouped into 3 categories: normal (n=1326, BMI &lt;25 kg/m 2 ), overweight (n=1881, BMI 25-30 kg/m 2 ), and obese (n=1638, BMI ≥30 kg/m 2 ). Cardiac structure and function were assessed by 2D echocardiography by a core lab. Non-parametric trend, χ 2 tests, linear, and logistic regression were used for this analysis. A two-sided p-value &lt;0.05 was considered significant. Results: Participants who were obese were younger, more likely to be black, and had higher rates of diabetes and hypertension than those who were overweight or had a normal BMI (table). Participants with obesity had larger biventricular cavity sizes, higher left ventricular (LV) mass index, more diastolic dysfunction, and more abnormal geometry (concentric/eccentric hypertrophy or concentric remodeling) than those who were overweight or normal (all p &lt;0.0001). After adjustment (table), right ventricular (RV) function was lowest in obese participants, but there was no significant difference observed in LV ejection fraction. Conclusion: In ARIC, obesity is associated with increased LV remodeling, impaired diastolic function, and decreased RV function even after adjustment for significant covariates. The relationship of these findings to subsequent clinical events and whether they can be mitigated by weight loss or maintenance warrants further study.
Putti With a Wine Press
Authors: M. Therese Southgate
Journal: JAMA (1999)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Two cases of vulval pigmented extramammary Paget’s disease: histochemical and immunohistochemical studies
Authors: H. Chiba, T. Kazama, T. Takenouchi, S. Nomoto, S. Yamada, O. Tago, M. Ito
Journal: British Journal of Dermatology (2000)

Abstract We describe two Japanese female patients with pigmented extramammary Paget’s disease (EMPD); one patient had a dark brown plaque and the other had a reddish patch with a pigmented area, both affecting the vulval region. Histochemical and immunohistochemical examinations confirmed EMPD with melanocyte colonization; plump tumour cells with a large nucleus and pale cytoplasm that were positive for CAM 5.2 and CEA proliferated singly or in nests in the epidermis, and scattered among the tumour cells were many dendritic cells with a large amount of melanin that were positive for HMB-45 and S-100 protein. Fontana–Masson (FM) stain showed many positive cells with well-developed dendritic processes within and around tumour nests. Histochemical and immunohistochemical studies of non-pigmented EMPD cases on the same region showed that HMB-45 positive cells were sparse or not detected at all, and that also FM staining-positive cells were decreased or not detected, and their dendritic processes were poorly formed. The present study suggests that there might be heterogeneity in EMPD in terms of relationships between Paget’s cells and melanocytes.
438. In Vitro Studies towards the Development of a Recombinant Adeno-Associated Virus for the Treatment of Medium-Chain Acyl-CoA Dehydrogenase Deficiency
Authors: Jennifer A. Bongorno, John Guy, Alfred S. Lewin
Journal: Molecular Therapy (2004)

Neuropathy Ataxia and Retinitis Pigmentosa (NARP) is a maternally inherited disease that leads to various types of retinopathies as well as dementia and skeletal muscle weakness. It is caused by point mutations in the mitochondrial gene ATP6, which encodes one of the subunits of ATP synthase. Manfredi et al (2002) have already shown rescue of this defect in human cells in culture using a mitochondrially targeted nuclear encoded version of the ATP6 protein. There are currently no animal models of this disease, so we are developing a mouse model using an AAV-vectored ribozyme imported into mitochondria to disrupt the ATP6 mRNA.
Effects of PS-341 on the Activity and Composition of Proteasomes in Multiple Myeloma Cells
Authors: Mikael Altun, Paul J. Galardy, Reshma Shringarpure, Teru Hideshima, Richard LeBlanc, Kenneth C. Anderson, Hidde L. Ploegh, Benedikt M. Kessler
Journal: Cancer Research (2005)

Abstract Multiple myeloma is a B-cell malignancy for which no curative therapies exist to date, despite enormous research efforts. The remarkable activity of the proteasome inhibitor bortezomib (PS-341, Velcade) observed in clinical trials of patients with relapsed refractory myeloma has led to investigations of the role of the ubiquitin-proteasome pathway in the pathogenesis of myeloma. Here we report a biochemical analysis of proteasome activity and composition in myeloma cells exposed to PS-341 in the presence or absence of cytokines present in the bone marrow milieu. We observed that the myeloma cell lines MM1.S, RPMI8226, and U266 contain active immunoproteasomes, the amount of which is enhanced by IFN-γ and tumor necrosis factor-α. Using a radiolabeled active site–directed probe specific for proteasome catalytic subunits, we show that PS-341 targets the β5 and β1 subunits in a concentration-dependent manner. Furthermore, PS-341 also targeted the corresponding catalytic subunits of the immunoproteasome, β5i and β1i, respectively. These data suggest that PS-341 targets both normal and immunoproteasome species to a similar extent in myeloma cells.
Abstract 17960: Influence of a Weight Management Intervention for Overweight and Obese Cardiac Rehabilitation Patients on Macronutrient Dietary Intake and Use of Weight Loss Strategies
Authors: Susan A Barnason, Carol Pullen, Lani Zimmerman, Paula Schulz
Journal: Circulation (2014)

Introduction: The majority of cardiac patients who enter cardiac rehabilitation (CR) are overweight. However, few patients lose enough weight to reduce their risk for heart disease. Purpose: To examine the influence of a weight management (WM) intervention for overweight and obese CR patients on the outcomes of dietary macronutrient (protein, carbohydrate, and fat) intake and use of WM strategies. Methods: Overweight or obese CR patients were randomized to a 12-week WM intervention (n=22) or usual care (UC) (n=21) group. Baseline, 4- and 6-month data were obtained after cardiac revascularization [coronary artery bypass surgery (CABS) or percutaneous coronary intervention (PCI)]. The 3-day diet diary, analyzed with the Minnesota Nutrition Data System V5.0, measured dietary macronutrient intake. The Diet and Exercise Self-Management survey measured subjects’ use of WM strategies. Results: Using RM ANCOVA, there were no significant group * time interactions controlling for % of calories from dietary fat, carbohydrate or protein intake at baseline. There were significant main effects by group, with the WM group having a significantly [F(1, 38)=4.2, p=.04] lower % intake of calories from dietary fat (29.9% compared to 34.1% for the UC group); and a significantly [F(1,38)=8.5, p=.006] higher % intake of calories from protein intake (23.7% compared to 19.9% for the usual care group). At 4-months after CABS or PCI, the WM group reported significantly higher use of WM diet behavior strategies for self-monitoring diet intake [F(1,38)=11.3, p=.002], planning [F(1,38)=9.7, p=.003], preparing and buying [F(1,38)=12.2, p=.001], and portion control [F(1,38)=7.8, p=.008]. Conclusions: The WM intervention influenced percentages of macronutrient dietary intake consistent with heart healthy diet recommendations. The WM intervention had an impact on improving reported use of weight loss strategies. Findings support the importance of a WM intervention for overweight and obese cardiac patients to improve weight outcomes not achieved in CR participation alone. Further research in a larger, controlled study is needed to examine how WM strategies can be integrated as an augmented intervention into standard CR.
Abstract 257: Perceptions of Inadequate Resuscitation Preparedness Within ACLS-Certified Emergency Medicine Residents and Nurses
Authors: Kiera von Besser, Colleen M Donovan, Florence D Vanek, Thomas M Smith, Kirkland N Lozado, Benjamin S Abella, Lance B Becker, Raina M Merchant
Journal: Circulation (2010)

Background: The quality of cardiopulmonary resuscitative efforts is suboptimal in the setting of in-hospital cardiac arrests and unsupervised internal medicine residents often feel unprepared to le...
Modulation of T-cell-mediated immunity in tumor and graft-versus-host disease models through the LIGHT co-stimulatory pathway
Authors: Koji Tamada, Koji Shimozaki, Andrei I. Chapoval, Gefeng Zhu, Gabriel Sica, Dallas Flies, Tom Boone, Hailing Hsu, Yang-Xin Fu, Shigekazu Nagata, Jian Ni, Lieping Chen
Journal: Nature Medicine (2000)
Mercury pigmentation from industrial exposure.
Authors: CAMERON KENNEDY, ELIZABETH A. MOLLAND, W.J. HENDERSON, A.M. WHITELEY
Journal: British Journal of Dermatology (1977)

A study has been made of facial pigmentation resulting from industrial inorganic mercury exposure. Electron microscopy has shown electron-dense 400--900 nm aggregates of 12 nm particles in dermal macrophages and free in the dermis. Use of the analytical electron microscope has enabled direct confirmation of the presence of mercury in these aggregates. The unexpected finding of coexistent selenium is discussed.
Epigenetic inactivation of the E-cadherin gene in eyelid sebaceous gland carcinoma
Authors: P. Jayaraj, S. Sen, A. Sharma, K. Chosdol, S. Kashyap, A. Rai, N. Pushker, M.S. Bajaj, S. Ghose
Journal: British Journal of Dermatology (2012)

Journal Article Epigenetic inactivation of the E‐cadherin gene in eyelid sebaceous gland carcinoma Get access P. Jayaraj, P. Jayaraj Department of Ocular Pathology, All India Institute of Medical Sciences, New Delhi 110029, India Search for other works by this author on: Oxford Academic Google Scholar S. Sen, S. Sen Department of Ocular Pathology, All India Institute of Medical Sciences, New Delhi 110029, India Seema Sen. E‐mail: ssenop@rediffmail.com Search for other works by this author on: Oxford Academic Google Scholar A. Sharma, A. Sharma Department of Ocular Microbiology, All India Institute of Medical Sciences, New Delhi, India Search for other works by this author on: Oxford Academic Google Scholar K. Chosdol, K. Chosdol Department of Biochemistry, All India Institute of Medical Sciences, New Delhi, India Search for other works by this author on: Oxford Academic Google Scholar S. Kashyap, S. Kashyap Department of Ocular Pathology, All India Institute of Medical Sciences, New Delhi 110029, India Search for other works by this author on: Oxford Academic Google Scholar A. Rai, A. Rai National Centre for Disease Control, Division of Biochemistry and Biotechnology, New Delhi, India Search for other works by this author on: Oxford Academic Google Scholar N. Pushker, N. Pushker Department of Ophthalmoplasty Service, Dr. Rajendra Prasad Centre for Ophthalmic Sciences, All India Institute of Medical Sciences, New Delhi, India Search for other works by this author on: Oxford Academic Google Scholar M.S. Bajaj, M.S. Bajaj Department of Ophthalmoplasty Service, Dr. Rajendra Prasad Centre for Ophthalmic Sciences, All India Institute of Medical Sciences, New Delhi, India Search for other works by this author on: Oxford Academic Google Scholar S. Ghose S. Ghose Department of Ophthalmoplasty Service, Dr. Rajendra Prasad Centre for Ophthalmic Sciences, All India Institute of Medical Sciences, New Delhi, India Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 167, Issue 3, 1 September 2012, Pages 583–590, https://doi.org/10.1111/j.1365-2133.2012.10968.x Published: 01 September 2012 Article history Accepted: 22 March 2012 Published: 01 September 2012
Multitargeted kinase inhibition and sustained biological effects of CHIR-258 contribute to enhanced preclinical efficacy
Authors: Daniel E. Lopes de Menezes, Jing Peng, Evelyn N. Garrett, Yan Tang, Sang H. Lee, Lea Aukerman, Carla Heise
Journal: Cancer Research (2005)

678  Cancer is a complex disease that involves multiple genetic defects that drive tumor-cell proliferation, suggesting that simultaneously inhibiting multiple cell signaling pathways may lead to a more favorable therapeutic outcome. In this work we examined the activity of CHIR-258, a novel, orally active, small molecule, that exhibits a multitarget kinase selectivity against Class III, IV and V receptor tyrosine kinases (RTKs). Biochemical IC50s of CHIR-258 for FLT3 = 1 nM; cKIT = 2 nM; VEGFR1/2/3 ∼ 8 nM; FGFR1/3 ∼ 10nM;, PDGFRb = 27 nM; and CSF-R1 = 36 nM. The in vivo activity of CHIR-258 was shown to result from direct inhibition of RTK signaling and consequent induction of apoptosis in tumor cells, in addition to potent inhibition of angiogenesis. The anti-tumor efficacy of CHIR-258 was evaluated in a variety of murine and human solid tumor models (colon, prostate, breast, ovarian) and hematological cancers (leukemia and myeloma), and compared with that of more “selective” kinase inhibitors currently in clinical development. In solid tumor models, CHIR-258 exhibited potent tumor inhibition, including regression, and was more effective than more “selective” RTK inhibitors. When compared to a RTK inhibitor with a similar target profile and “broad” selectivity as CHIR-258, efficacy was generally equivalent with continuous daily dosing. However, CHIR-258 exhibited more potent anti-tumor activity when cyclic or intermittent dosing schedules were evaluated. Pharmacodynamic studies have shown that target modulation and inhibition of signaling pathways were maintained for 24 hours followed by induction of tumor cell apoptosis. Our data suggests that biological activity of CHIR-258 is dependent upon degree and duration of response, which likely plays a role in the efficacy observed in the absence of continuous drug treatment and differentiates CHIR-258 from other RTK inhibitors. In conclusion, these data support the development of multitargeted agents like CHIR-258 based on our understanding of the relative contributions of the disease-relevant targets in tumorigenesis.
OBSTETRICS AND GYNÆCOLOGY.
Authors: Andrew McCarthy, Bill Hunter, Peter Cox
Journal: JAMA (1884)

High acuity and critical care presentations in obstetrics and gynaecology are not uncommon, and when seen in the retrieval setting they present pathophysiology and risk avoidance challenges for the retrieval physician, coordinator, and system. The particular risks in obstetric retrieval which are associated with the consideration of infant risk, and the emotive implications of perinatal death, create additional pressure. The wellbeing of the mother is in all circumstances the priority, and it is important that this drives decision-making and planning. Careful consideration and consultation with specialist retrieval coordinators with obstetric experience and qualifications is important to optimize plans. These plans often revolve around the wisdom of intervention or delivery pre, post, or instead of high-risk transfer. Experience, perspective, and understanding of practitioner and system capability will inform best decisions and outcomes.
FATAL "CONSTRICTIVE" PERICARDITIS DUE TO ISOLATED SUPPURATIVE PERICARDITIS THE RESULT OF INFECTED ABORTION; CASE REPORT
Authors: Simon Koletsky, Robert E. Brownlee
Journal: Annals of Internal Medicine (1940)

Case Reports1 November 1940FATAL "CONSTRICTIVE" PERICARDITIS DUE TO ISOLATED SUPPURATIVE PERICARDITIS THE RESULT OF INFECTED ABORTION; CASE REPORTSIMON KOLETSKY, M.D., ROBERT E. BROWNLEE, M.D.SIMON KOLETSKY, M.D.Search for more papers by this author, ROBERT E. BROWNLEE, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-14-5-924 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe object of this report is to describe a case of isolated suppurative pericarditis complicating a postabortive thrombophlebitis of the pelvic veins. Only one similar instance of suppurative pericarditis following an abortion has been found in a survey of the literature.1 The pericarditis was evidently embolic in origin and developed about two weeks after the abortion. The patient then rapidly developed the symptoms of severe cardiac constriction † and died in circulatory failure within a period of eight weeks. An autopsy revealed extensive organization of the pericarditis and the formation of thick and rigid pericardial scar tissue.CASE REPORTClinical...Reference1. DUJOL G: Péricardite purulente à staphylocoques au cours d'une infection post-abortum, Bull. Soc. d'obst. et de gynéc., 1929, xviii, 247. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: *Received for publication July 7, 1939.From the Institute of Pathology and the Department of Medicine, Western Reserve University and the University Hospitals, Cleveland, Ohio.†The term constrictive is employed because of its widespread use in the literature. The term applies only in its figurative sense of holding fast or gripping, not necessarily in the sense of drawing together or rendering narrower or smaller. The lesion constrains the heart's diastolic expansion, but does not truly reduce the size of the heart in its systolic phase nor in its weight. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 November 1940Volume 14, Issue 5Page: 924-929KeywordsAutopsyHealth surveysHeartHospital medicineLesionsScarsVeins ePublished: 1 December 2008 Issue Published: 1 November 1940 PDF downloadLoading ...
Abstract 3859: WNT1 Inducible Signaling Pathway Protein-1 Blocks Doxorubicin-mediated Cardiomyocyte Death by Suppressing p53, Bax and Bcl-XS, and Activating PI3K-Akt-p70S6K-Survivin Signaling
Authors: Balachandar Venkatesan, Srinivas Mummidi, Anthony J Valente, Bysani Chandrasekar
Journal: Circulation (2009)
Secondary Schooling and HIV Risk
Authors: M. J. Friedrich
Journal: JAMA (2015)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Use of Biologics for Rheumatoid Arthritis Tempered by Concerns Over Safety, Cost
Authors: Sarah Pressman Lovinger
Journal: JAMA (2003)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Expression quantitative trait locus analysis for translational medicine
Authors: Greg Gibson, Joseph E Powell, Urko M Marigorta
Journal: Genome Medicine (2015)

Abstract Expression quantitative trait locus analysis has emerged as an important component of efforts to understand how genetic polymorphisms influence disease risk and is poised to make contributions to translational medicine. Here we review how expression quantitative trait locus analysis is aiding the identification of which gene(s) within regions of association are causal for a disease or phenotypic trait; the narrowing down of the cell types or regulators involved in the etiology of disease; the characterization of drivers and modifiers of cancer; and our understanding of how different environments and cellular contexts can modify gene expression. We also introduce the concept of transcriptional risk scores as a means of refining estimates of individual liability to disease based on targeted profiling of the transcripts that are regulated by polymorphisms jointly associated with disease and gene expression.