THE USE OF GLYCINE IN THE TREATMENT OF MYASTHENIA GRAVIS
Authors: Earl O. G. Schmitt
Journal: Annals of Internal Medicine (1934)

Article1 February 1934THE USE OF GLYCINE IN THE TREATMENT OF MYASTHENIA GRAVISEARL O. G. SCHMITT, M.D., F.A.C.P.EARL O. G. SCHMITT, M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-7-8-948 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptDEFINITIONMyasthenia gravis, or Erb-Goldflam disease, may be defined as a disease characterized by an incapacity on the part of the voluntary motor system for sustained effort.1 It is a disease of the muscles themselves without involvement of the nervous system and affects most commonly the muscles of the eyes, those of the face, and the muscles of mastication.HISTORICALThe disease was first described by Wilkes in 1877. Erb, in 1878, characterized the condition as being a combination of bulbar symptoms, ptosis, and weakness of the muscles of mastication and of the muscles of the back of the neck....References1. KESCHNERSTRAUSS MI: Myasthenia gravis, Arch. Neur. and Psychiat., 1927, xvii, 337-376. CrossrefGoogle Scholar2. WEIGERT C: Pathologisch-anatomischer Beitrag zur Erb'schen Krankheit (Myasthenia gravis), Neurol. Centralbl., 1901, xx, 597. Google Scholar3. BUZZARD EF: The clinical history and postmortem examination of five cases of myasthenia gravis, Brain, 1905, xxviii, 438-483. Google Scholar4. BELL ET: Tumors of the thymus in myasthenia gravis, Jr. Nerv. and Ment. Dis., 1917, xlv, 130. CrossrefGoogle Scholar5. STARR MA: Myasthenia gravis, Jr. Nerv. and Ment. Dis., 1912, xxxix, 721-731. CrossrefGoogle Scholar6. MELLA H: Irradiation of the thymus in myasthenia gravis, Med. Clin. N. Am., 1923, vii, 939-949. Google Scholar7. EDGEWORTH H: Report of progress on use of ephedrin in case of myasthenia gravis, Jr. Am. Med. Assoc., 1930, xciv, 1136. CrossrefGoogle Scholar8. PEMBERTON R: The metabolism of myasthenia gravis, with a suggestion regarding treatment, Am. Jr. Med. Sci., 1910, cxxxix, 816-821. CrossrefGoogle Scholar9. BOOTHBY WM: Myasthenia gravis; preliminary report on effect of treatment with glycine, Proc. Staff Meet. Mayo Clin., 1932, vii, 557-562. Google Scholar10. MILHORATTECHNERTHOMAS ATFK: Significance of creatine in progressive muscular dystrophy, and treatment of this disease with glycine, Proc. Soc. Exper. Biol. and Med., 1932, xxix, 609-611. CrossrefGoogle Scholar11. BEARDBARNES HHBO: Influence of feeding proteins, amino acids and related substances upon creatine-creatinine metabolism, Jr. Biol. Chem., 1931, xciv, 49-69. Google Scholar12. LUCK JM: Metabolism of amino acids, Jr. Biol. Chem., 1928, lxxvii, 13-26. CrossrefGoogle Scholar13. BOOTHBY WM: Myasthenia gravis: second report on effect of treatment with glycine, Proc. Staff Meet. Mayo Clin., 1932, vii, 737-756. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: San Jose, California*Read before the General Medicine Section of the California Medical Association at the sixty-second annual session, Del Monte, April 24-27, 1933. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byTHE RÔLE OF ARGININE AND GLYCINE IN CHICK NUTRITIONCreatinuria in Patients with palpable muscle affections (Myosis) 1 February 1934Volume 7, Issue 8Page: 948-959KeywordsEye diseasesGlycineMotor systemMusclesMyasthenia gravisNervous systemPtosis ePublished: 1 December 2008 Issue Published: 1 February 1934 PDF downloadLoading ...