Chronic Active ("Lupoid") Hepatitis
Authors: MARGARET J. MACLACHLAN
Journal: Annals of Internal Medicine (1965)

Article1 March 1965Chronic Active ("Lupoid") HepatitisA Clinical, Serological, and Pathological Study of 20 PatientsMARGARET J. MACLACHLAN, M.D., GERALD P. RODNAN, M.D., F.A.C.P., WILLIAM M. COOPER, M.D., F.A.C.P., R. H. FENNELL JR., M.D.MARGARET J. MACLACHLAN, M.D.Search for more papers by this author, GERALD P. RODNAN, M.D., F.A.C.P.Search for more papers by this author, WILLIAM M. COOPER, M.D., F.A.C.P.Search for more papers by this author, R. H. FENNELL JR., M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-62-3-425 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptIn 1951, Kunkel and associates (1) drew attention to a group of young women with chronic liver disease who had hypergammaglobulinemia of such an extreme degree as to distinguish their serum protein patterns from those of a large number of patients with other forms of hepatic dysfunction. When 26 of these patients were later described in detail by Bearn, Kunkel, and Slater (2), it was noted that they presented certain clinical features not usually observed in Laennec's cirrhosis. These included recurrent fever, polyarthralgia and arthritis, pericarditis, pleural effusions, and the early appearance of splenomegaly. Because of the predominance in women...References1. 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CrossrefMedlineGoogle Scholar77. STEINER JW: Investigations of allergic liver injury. I. Light, fluorescent and electron microscopic study of the effects of soluble immune aggregates. Amer. J. Path. 38: 411, 1961. MedlineGoogle Scholar78. FENNELLSANTAMARIA RHA: Anaphylaxis in the rat. Immunohistochemical and histochemical studies of the liver. Amer. J. Path. 41: 521, 1962. MedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: MARGARET J. MACLACHLAN, M.D.; GERALD P. RODNAN, M.D., F.A.C.P.; WILLIAM M. COOPER, M.D., F.A.C.P.; R. H. FENNELLJR., M.D.Affiliations: Pittsburgh, PennsylvaniaFrom the Departments of Medicine and Pathology and Presbyterian-University Hospital, University of Pittsburgh School of Medicine, Pittsburgh, Pa.This study was supported by Graduate Training Grant 2A-5031 in Arthritis and Rheumatism and in part by grant 5 MOI FR-00056 from the U. S. Public Health Service, Bethesda, Md.Requests for reprints should be addressed to 985 Scaife Hall, Department of Medicine, University of Pittsburgh, Pittsburgh, Pa. 15213. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited bySystematic review with meta‐analysis: outcomes of pregnancy in patients with autoimmune hepatitisImmunoserological and histological differences between autoimmune hepatitis with acute presentation and chronic autoimmune hepatitisLaboratory TestsGastrointestinalLaboratory Testing for Liver DiseaseHEPATIC DISEASE AND SYSTEMIC LUPUS ERYTHEMATOSUS: COINCIDENCE OR CONVERGENCEAuto-immune chronic active hepatitis: A specific entity? 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WINSHIP, M.D.Smooth Muscle Autoantibody in “Autoimmune” HepatitisCase 20-1966Serum β1A (β1C) globulin levels in systemic lupus erythematosus: Their relationship to clinical and renal histologic findingsEntero-arthropathy: The Coexistence of Articular and Gastrointestinal Manifestations in Systemic DiseaseThe Autoimmune DiseasesIMMUNOGLOBULINS IN VIRAL HEPATITIS AND ACTIVE ALCOHOLIC LIVER-DISEASEConcurrent “active juvenile cirrhosis” and “primary pulmonary hypertension”The Problem of Chronicity in Liver Disease 1 March 1965Volume 62, Issue 3Page: 425-462KeywordsArthralgiaArthritisChronic hepatitisCirrhosisFibrosisHospital medicineHypergammaglobulinemiaSerum proteinsSplenomegalyUlcerative colitis ePublished: 1 December 2008 Issue Published: 1 March 1965 Copyright & PermissionsCopyright ©, 1965, by The American College of PhysiciansPDF downloadLoading ...