Ischemic Colitis Associated with Anti-β<sub>2</sub> Glycoprotein-I Antibody
Authors: Nelson S. Yee, Stephen J. Schuster, Gary R. Lichtenstein
Journal: Annals of Internal Medicine (2002)

Letters20 August 2002Ischemic Colitis Associated with Anti-β2 Glycoprotein-I AntibodyNelson S. Yee, MD, PhD, Stephen J. Schuster, MD, and Gary R. Lichtenstein, MDNelson S. Yee, MD, PhDUniversity of Pennsylvania School of Medicine; Philadelphia, PA 19104-4283Search for more papers by this author, Stephen J. Schuster, MDUniversity of Pennsylvania School of Medicine; Philadelphia, PA 19104-4283Search for more papers by this author, and Gary R. Lichtenstein, MDUniversity of Pennsylvania School of Medicine; Philadelphia, PA 19104-4283Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-137-4-200208200-00027 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:Ischemic colitis associated with the antiphospholipid syndrome has been attributed to lupus anticoagulants and anticardiolipin antibodies. Anti-β2 glycoprotein-I antibodies appear to correlate more closely with the diagnosis of the antiphospholipid syndrome than antiphospholipid antibodies (1), and they increase the risk for deep venous thrombosis and pulmonary embolism in patients without systemic lupus erythematosus (2, 3). We report a case of ischemic colitis in a woman who used oral contraceptives and had elevated levels of anti-β2 glycoprotein-I IgM antibodies.A 25-year-old nonsmoking woman who had used oral contraceptives for 2 years presented with abrupt onset of severe abdominal ...References1. Guerin J, Feighery C, Sim RB, Jackson J. Antibodies to beta2-glycoprotein I–a specific marker for the antiphospholipid syndrome. Clin Exp Immunol. 1997;109:304-9. [PMID: 9276526] CrossrefMedlineGoogle Scholar2. Wahl DG, De Maistre E, Guillemin F, Regnault V, Perret-Guillaume C, Lecompte T. Antibodies against phospholipids and β 2-glycoprotein I increase the risk of recurrent venous thromboembolism in patients without systemic lupus erythematosus. QJM. 1998;91:125-30. [PMID: 9578894] CrossrefMedlineGoogle Scholar3. Zanon E, Prandoni P, Vianello F, Saggiorato G, Carraro G, Bagatella P, et al . Anti-beta2-glycoprotein I antibodies in patients with acute venous thromboembolism: prevalence and association with recurrent thromboembolism. Thromb Res. 1999;96:269-74. [PMID: 10593429] CrossrefMedlineGoogle Scholar4. Deana DG, Dean PJ. Reversible ischemic colitis in young women. Association with oral contraceptive use. Am J Surg Pathol. 1995;19:454-62. [PMID: 7694947] CrossrefMedlineGoogle Scholar5. Wahl DG, Guillemin F, de Maistre E, Perret-Guillaume C, Lecompte T, Thibaut G. Meta-analysis of the risk of venous thrombosis in individuals with antiphospholipid antibodies without underlying autoimmune disease or previous thrombosis. Lupus. 1998;7:15-22. [PMID: 9493144] CrossrefMedlineGoogle Scholar Author, Article, and Disclosure InformationAuthors: Nelson S. Yee, MD, PhD; Stephen J. Schuster, MD; Gary R. Lichtenstein, MDAffiliations: University of Pennsylvania School of Medicine; Philadelphia, PA 19104-4283 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 20 August 2002Volume 137, Issue 4Page: 299KeywordsAnticoagulantsAntiphospholipid syndromeColitisHemorrhageOral contraceptive therapyProteinsUlcerative colitisVeinsVenomsVenous thromboembolism ePublished: 20 August 2002 Issue Published: 20 August 2002 Copyright & PermissionsCopyright © 2002 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...