tbuckley/cabot-search huggingface dataset:
CHRONIC GLOMERULONEPHRITIS FOR FORTY YEARS: REPORT OF CASE
Authors: NORMAN M. KEITH, M.D., HOWARD M. ODEL, M.D., F.A.C.P., ARCHIE H. BAGGENSTOSS, M.D.
Journal: Annals of Internal Medicine (1944)

ExcerptThe course of chronic glomerulonephritis has been a subject of interest since Bright1considered it in a paper published in 1840. His appraisal of the course was necessarily limited to a period of 10 to 15 years; however, Mann2in 1895 reported a case which he had followed for 28 years. Recently two factors have stimulated a renewed interest in the subject. The first is that clinicians have made a more intensive application of physiologic principles to the immediate problem of the patient and their findings created a desire for the second factor, namely, an accurate record of the whole...
Stem Cell Research Probed
Authors: Joan Stephenson
Journal: JAMA (2006)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
A phase 1 study of ACE‐536, a regulator of erythroid differentiation, in healthy volunteers
Authors: Kenneth M. Attie, Mark J. Allison, Ty McClure, Ingrid E. Boyd, Dawn M. Wilson, Amelia E. Pearsall, Matthew L. Sherman
Journal: American Journal of Hematology (2014)

ACE‐536, a recombinant protein containing a modified activin receptor type IIB, is being developed for the treatment of anemias caused by ineffective erythropoiesis, such as thalassemias and myelodysplastic syndromes. ACE‐536 acts through a mechanism distinct from erythropoiesis‐stimulating agents to promote late‐stage erythroid differentiation by binding to transforming growth factor‐β superfamily ligands and inhibiting signaling through transcription factors Smad 2/3. The goal of this Phase 1 study was to evaluate the safety, tolerability, pharmacokinetics, and pharmacodynamic effects of ascending dose levels of ACE‐536 in healthy volunteers. Thirty‐two postmenopausal women were randomized in sequential cohorts of eight subjects each to receive up to two doses of either ACE‐536 (0.0625–0.25 mg/kg) or placebo (3:1 randomization) given subcutaneously every 2 weeks. Mean baseline age was 59.4 years, and hemoglobin was 13.2 g/dL. ACE‐536 was well tolerated at dose levels up to 0.25 mg/kg over the 1‐month treatment period. There were no serious or severe adverse events, nor clinically meaningful changes in safety laboratory measures or vital signs. Mean ACE‐536 AUC 0–14d and C max increased proportionally after first dose; mean t ½ was 15–16 days. Dose‐dependent increases in hemoglobin concentration were observed, beginning 7 days after initiation of treatment and maintained for several weeks following treatment. The proportion of subjects with a hemoglobin increase ≥1.0 g/dL increased in a dose‐dependent manner to 83.3% of subjects in the highest dose group, 0.25 mg/kg. ACE‐536 was well tolerated and resulted in sustained increases in hemoglobin levels in healthy postmenopausal women. Am. J. Hematol. 89:766–770, 2014. © 2014 Wiley Periodicals, Inc.
<i>AL 3</i>
Authors: Carrie A. Butt
Journal: JAMA (2015)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Abstract P151: Duration and Types of Statin Use and Long-Term Risk of Type 2 Diabetes Among Men and Women with Hypercholesterolemia: Findings From 3 Prospective Cohorts
Authors: Dong D Wang, Yanping Li, An Pan, Edward Giovannucci, Walter Willett, JoAnn Mason, Frank Hu
Journal: Circulation (2015)

Introduction: Although effective for cardiovascular disease (CVD) prevention, statin use has been associated with an elevated risk of type 2 diabetes (T2D). However, data on duration of use and types of statins are still limited. Hypothesis: We hypothesized that longer duration of statin use was associated greater risk of T2D and the association varied with different types of statin. Methods: We analyzed participants with self-reported hypercholesterolemia from the Nurses’ Health Study (NHS, 30 480 participants), the Nurses’ Health Study II (NHS II, 21 773 participants) and the Health Professionals Follow-up Study (HPFS, 12 064 participants) who were free of diabetes, CVD and cancer at baseline. Information on statin use was self-reported by participants every 2 years from 2000 for NHS and HPFS, and 1999 for NHS II. Incident cases of T2D were first self-reported on the biennial questionnaires and then confirmed by a validated supplementary questionnaire through 2010 or 2011. Participants also reported the...
HIV Drug Resistance Testing Shows PromiseUltrasound May Markedly Improve Cancer Detection in Dense BreastsAdvisory Board Aims to Develop Pragmatic Public Health PoliciesDiet Supplement Data on the InternetHIV Drug Resistance Testing Shows PromiseUltrasound May Markedly Improve Cancer Detection in Dense BreastsAdvisory Board Aims to Develop Pragmatic Public Health PoliciesDiet Supplement Data on the Internet
Authors: J Stephenson
Journal: JAMA (1999)

WASHINGTON—AIDS experts are predictingthatnewtestsdesignedto identifydrugresistant strains of HIV will soon emerge as important tools tohelpphysiciansmake decisions regarding therapeutic regimens for patients with the infection. That was the prevailing take-home message from AIDS scientists who gathered here last month for an international workshop, “Clinical IndicationsofHIVDrugResistance Monitoring,” organized by International Medical Press and The Johns Hopkins School of Medicine. “It’s increasingly apparent that these tests will be part of the monitoring and management of HIV patients in the very near future,” said Douglas Richman, MD, of the University of California, San Diego, and the San Diego VA Medical Center. In a recent consensus statement, an International AIDS Society–USA panel reviewed issues related to antiretroviral drug resistance testing and predicted that “resistance testing will likely be useful for identifying drugs that will not be optimally active in a treatment regimen.” However, it is premature to recommend widespread use of the new assays in clinical practice, Richman noted. “We need to generate more data to validate and characterize each of the assays, as well as assess their relative benefits and limits and how to use them,” he said.
Evidence for Circulating Bone Marrow-Derived Endothelial Cells
Authors: Qun Shi, Shahin Rafii, Moses Hong-De Wu, Errol S. Wijelath, Cong Yu, Atsushi Ishida, Yuji Fujita, Sudesh Kothari, Robert Mohle, Lester R. Sauvage, Malcom A.S. Moore, Rainer F. Storb, William P. Hammond
Journal: Blood (1998)
RISK OF THERAPY-RELATED LEUKAEMIA AND PRELEUKAEMIA AFTER HODGKIN'S DISEASE
Authors: Jens Pedersen-Bjergaard, Severin Olesen Larsen, Jan Struck, HeineH. Hansen, Lena Specht, Jens Ersbøll, MogensM. Hansen, NisI. Nissen
Journal: The Lancet (1987)
200. Cholesterol Modified Polyurethane as a Matrix for Cell Based Cardiovascular Therapy Using Blood Outgrowth Endothelial Cells (BOEC): Potential for Lentivirus Mediated Gene Therapy
Authors: Stanley J. Stachelek, Ivan S. Alferiev, Phillip W. Zoltick, Jeanne M. Connolly, Richard W. Bianco, Robert P. Hebbel, Robert J. Levy
Journal: Molecular Therapy (2004)

Polyurethane is a durable elastomer capable of serving as a gene delivery platform in the cardiovascular system. Precoating polyurethane cardiovascular devices with a layer of autologous endothelial cells would hypothetically protect the device from thrombus formation. However, biocompatibility issues often hinder attempts to seed vascular devices with endothelial cells. In these studies, blood outgrowth endothelial cells (BOEC's) were used to test the hypothesis that covalent attachment of cholesterol to the polyurethane amide group would create a high affinity surface for attachment and adhesion of autologous BOEC's, prior to implantation as cardiovascular devices. Cholesterol was covalently appended to the polyether polyurethane Tecothane, by activating polyurethane nitrogens and attaching a bromo-alkyl side chain. Expanded ovine BOEC's were cultured on the modified polyurethane to compare viability and cell retention under vascular flow conditions. BOEC susceptibility to lentivirus mediated ectopic gene expression was also analyzed, using a VSV-g pseudotyped, self-inactivating lentivirus with an internal CMV promoter driving an eGFP gene, in conjunction with growth on cholesterol modified polyurethane. Cell adhesion was investigated with BOEC's cultivated until confluence on Tecothane ± appended cholesterol, exposed to physiological shear stress (25 dynes/cm2) for two hours. BOEC's growing on cholesterol modified polyurethane retained 94.1 ± 0.36 % of cells. In contrast cells cultured on unmodified polyurethane retained only 4.56 ± 0.85 % (p = 0.02, n = 3) of the initial cells. Green fluorescent protein (GFP) encoding lentivirus (MOI = 250) vectors transduced 100% of cultured BOEC's. GFP expression was observed in all subcultured BOEC's beyond four cell passages strongly suggesting permanent ectopic gene incorporation. GFP expressing BOEC's continued to grow and express GFP on cholesterol modified polyurethane surfaces. In conclusion, cholesterol modified polyurethane seeded with BOEC's represent a formulation with great potential for intravascular cell based therapies.
Abstract 15165: A Green Tea Catechin, (-)-epicatechin-3-gallate, Suppresses Early After-depolarization in Long-term Cultured Cardiomyocytes
Authors: Adonis Z Wu, Sheng-Nan Wu, Cheng-I Lin, Shien-Fong Lin
Journal: Circulation (2014)

Introduction: Our previous study verified (-)-epicatechin-3-gallate (ECG), a green tea polyphenol, can act as a sodium channel agonist. However, the treating effects of ECG on the arrhythmic disorders, such as early after-depolarization (EAD) remain uncertain. Hypothesis: We hypothesize that ECG alters the rate of spontaneous action potential (sAP) and suppresses EAD through its action on voltage-gated sodium current ( I Na ). Methods: By using patch-clamp technique, we characterized the alterations of sAP in cultured neonatal rat ventricular myocytes (NRVMs). We further examined the effects of ECG on the firing rate and morphology of sAP. Results: The sAP alterations were investigated in two stages. The early stage, 3-4 days post cell isolation, involved a gradual suppression of amplitude (~36.9%) and frequency (~72%) in the early culture periods, followed by about two folds APD 90 prolongation in the late culture stage, &gt; 7 days post cell isolation. These changes of sAP were strongly correlated with dysfunction of I Na (r 2 =0.99) but not with I K or I to . With an increment in the incubating period, the I Na properties were also observed in the decrease of I Na density (~44%), negative shift of steady-state inactivation curve ( V h , -73.4±4.2 vs. 83.1±4.7 mV, p&lt;.05), and prolongation of the recovery time constant ( τ , 65.8±4.1 vs. 82.5±4.6 ms, p&lt;.05). The dysfunction of I Na appeared to result in an increased incidence of the bradycardia-dependent EAD. Treatment with ECG suppressed EAD via accelerating the I Na recovery time to normal, resulting in fast firing rate of the sAP as in early culture period. Conclusions: Long-term culture of myocytes leads to retardation of automaticity, APD prolongation, EAD occurrence, and concomitant I Na suppression. ECG restores I Na and cellular automaticity in long-term cultured NRVMs.
Abstract 13834: MURC/cavin-4 Aggravates Abdominal Aortic Aneurysm With JNK Overactivation in Vascular Smooth Muscle Cells
Authors: Kotaro Miyagawa, Takehiro Ogata, Naohiko Nakanishi, Tetsuro Hamaoka, Naoki Maruyama, Takeru Kasahara, Tomomi Ueyama
Journal: Circulation (2014)

Background: Abdominal aortic aneurysm (AAA) is a relatively common disease in the elderly population. MURC (muscle-restricted coiled-coil protein)/cavin-4, a fourth member of the cavin family which regulates caveolae function, is expressed in cardiomyocytes, smooth muscle cells, and skeletal myocytes. Mutations in MURC/Cavin-4 have been identified in patients with dilated cardiomyopathy. However, roles of MURC/Cavin-4 in vascular smooth muscle cells (VSMCs) and the development of AAA remain unknown. Methods and Results: To examine the role of MURC/Cavin-4 in AAA, we subjected wild-type (WT) and MURC/Cavin-4 knockout (MURC-/-) mice to a model of AAA induced by periaortic application of CaCl2. After six weeks of CaCl2 treatment, the internal aortic diameter assessed by ultrasonography was significantly increased in MURC-/- mice compared with WT mice. Measurement of the external aortic diameter after perfusion fixation also showed an increase in CaCl2-treated MURC-/- mice compared with CaCl2-treated WT mice....
Histologic phenotype–genotype correlation of corneal dystrophies associated with eight distinct mutations in the TGFBI gene11The authors have no commercial interest in the development or marketing of any of the products referred to in this article.
Authors: Paul Dighiero, Florence Niel, Pierre Ellies, François D’Hermies, Michèle Savoldelli, Gilles Renard, Marc Delpech, Sophie Valleix
Journal: Ophthalmology (2001)
Paroxysmal Tachycardia Related to the Menstrual Period
Authors: J. Hamilton Crawford, Louis H. Sigler, H. Fruchter
Journal: Annals of Internal Medicine (1932)

Article1 March 1932Paroxysmal Tachycardia Related to the Menstrual PeriodJ. HAMILTON CRAWFORD, M.D., F.A.C.P., LOUIS H. SIGLER, M.D., H. FRUCHTER, M.D.J. HAMILTON CRAWFORD, M.D., F.A.C.P.Search for more papers by this author, LOUIS H. SIGLER, M.D.Search for more papers by this author, H. FRUCHTER, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-5-9-1155 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptParoxysmal tachycardia is a disease of extreme interest in that so many factors in regard to it remain obscure. Although electrocardiography has enabled us to localize within narrow limits the region of the heart from which the paroxysms arise, no definite conclusions have been arrived at as to the mode of initiation and maintenance of the abnormal rhythm. Many causes have been described which were related, in different individuals, to the onset of the attacks, but the common factor which these possess still remains unsolved. In spite of this, however, it seems of value to record all possible etiological aspects...References1 VAQUEZPEZZI HC: Tachycardie paroxystique de type auriculaire, Bull. et mém. Soc. méd. d. hôp. de Paris, 1912, xxxiii, 360-370. Google Scholar2 SAVINI E: Études sur la tachycardie paroxystique (étiologie, pathogénie, formes, cliniques, traitement), Arch. d. mal. du coeur, 1912, v, 689-716. Google Scholar3 MARTINEZ GN: Recherches étiologiques sur la tachycardie paroxystique, Arch. d. mal. du coeur, 1925, xviii, 292-300. Google Scholar4 GERAUDEL E: Études sur la tachycardie paroxystique; tachycardie paroxystique et flutter, Arch. d. mal. du coeur, 1928, xxi, 273-287. Google Scholar5 LUTIER A: Crises de tachycardie de Basedow fruste chez une jeune fille mal réglée, Presse méd., 1929, xxxvii, 492. Google Scholar6 MEYERLACKNERSCHOCHET JJESS: Paroxysmal tachycardia in pregnancy, Jr. Am. Med. Assoc., 1930, xciv, 1901-1004. CrossrefGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Brooklyn, N.Y.*From the Department of Internal Medicine, Long Island College of Medicine, Brooklyn, New York.†Submitted for publication, July 17, 1931. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 March 1932Volume 5, Issue 9Page: 1155-1160KeywordsElectrocardiographyHeartTachycardia ePublished: 1 December 2008 Issue Published: 1 March 1932 PDF downloadLoading ...
Updated consensus statement on biological agents for the treatment of rheumatic diseases, 2006
Authors: D E Furst, F C Breedveld, J R Kalden, J S Smolen, G R Burmester, P Emery, E C Keystone, M H Schiff, P L C M van Riel, M E Weinblatt, M H Weisman
Journal: Annals of the Rheumatic Diseases (2006)
Abstract 12875: Multi-Omics Analysis Strategy is a Promising Approach for Global Identification of New Biomarkers Evaluating Disease Severity of Patients With Dilated Cardiomyopathy
Authors: Naoto Minamino, Mitsuhiro Nishigori, Hiroaki Yagi, Sayaka Muto, Osamu Seguchi, Tsukasa Osaki, Akikazu Mochizuki, Kazuki Sasaki, Masanori Asakura, Yoshihiko Ikeda, Hatsue Ishibashi-Ueda, Yae Kanai, Kenji Matsumoto, Takeshi Nakatani
Journal: Circulation (2014)

Introduction: Dilated cardiomyopathy (DCM) is an intractable disease and no radical treatment other than cardiac transplantation has been available until today. Because the number of donor heart is limited in Japan, implantation of left ventricular assist device (LVAD) is increasing. Patients can be weaned from LVAD, but no explicit criterion for weaning has been established. Aim: Discovery of novel biomarkers for evaluating severity/recovery of the DCM and biochemical status of the cardiomyocytes. Methods: Multi-omics analyses were performed with left ventricular tissues from heart transplant recipients or autopsy cases with idiopathic DCM and dilated phase of HCM (n=19), and compared with non-heart disease controls (n=8). Proteomic analysis was carried out with a Triple TOF5600 mass spectrometer and quantitatively compared using a 2DICAL software. Transcriptomic and epigenomic (DNA methylation) analysis were performed with Agilent DNA Microarray 44K and Infinium Methylation450 BeadChip kits. Results: 16...
Imre Joseph Pál Loefler
Authors: York John Craven, Lusaka John Jellis, Kampala Francis Omaswa
Journal: BMJ (2007)

Surgeon, controversial writer, and polymath

The death of Imre Loefler, at the age of 77 will be mourned in many quarters. He was a polymath, well versed in philosophy, history, ecology, and wildlife conservation, as well as medical education and surgery. His memory was prodigious. In his heavily accented speeches and in over 1000 precisely argued articles and scientific papers, he challenged the status quo in many differing fields. His audiences and his influence extended far from his home in suburban Nairobi.

Imre Joseph Pal Loefler was born in Budapest in 1929. His father was a civil servant. One grandfather was a classics teacher, the other a publisher and book collector whose library became an important factor in Imre's development. His grandmothers were Austrian and Bavarian so the home was bilingual. Within the ranks of the extended family were Uncle Joseph, an archbishop (later the Primate of the Catholic Church in Hungary), Uncle Victor, a general, and Aunt Paula, an Ursuline nun, who was the first woman to hold a PhD from a Hungarian university and tutor to the children of the Duke of Eszerhazy. The general, but even more so, the nun, had great influence on the boy.

His early schooldays were unremarkable; his only enthusiasm, scouting, he attributed to his desire to escape from home and his mother's religious moralising. In 1944 he was enrolled in an army cadet school. Unfortunately, with the Russians no more than a few kilometres from Budapest, all the cadets were soon taken by the German army, put into German uniforms, and sent to the Polish war front. After six months he escaped and made his way to Germany, where the Americans captured him in May 1945. In the prisoner of war camp he helped in a modest “clinic” and there performed his …
Systolic Hypertension in Elderly Persons
Authors: Arya M Sharma
Journal: JAMA (2004)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal