MUSCULAR RELAXATION IN TETANUS WITH SPECIAL REFERENCE TO THE EFFECT OF MEPHENESIN
Authors: R S DIAZ-RIVERA, F TRILLA, E R PONS
Journal: Annals of Internal Medicine (1954)

Article1 March 1954MUSCULAR RELAXATION IN TETANUS WITH SPECIAL REFERENCE TO THE EFFECT OF MEPHENESINR. S. DÍAZ-RIVERA, M.D., F.A.C.P., FRANCISCO TRILLA, M.D., EDUARDO R. PONS JR., M.D.R. S. DÍAZ-RIVERA, M.D., F.A.C.P.Search for more papers by this author, FRANCISCO TRILLA, M.D.Search for more papers by this author, EDUARDO R. PONS JR., M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-40-3-563 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptAmong the most important problems in the management of generalized tetanus are the following: the muscle rigidity, generalized muscle spasms and convulsions, causing death from severe exhaustion; respiratory failure from muscular paralysis; asphyxia from too frequent or too long maintained laryngeal spasms, and anoxemia due to obstruction of the respiratory passages. The use of d-tubocurarine chloride is fraught with danger, because almost complete curarization is required for the control of muscle spasms. Also, the effects are transitory and unpredictable, and severe respiratory depression and tracheal obstruction are at times unavoidable.1With the advent of 3 orthotoloxy-1, 2-propanediol (Mephenesin), favorable reports...Bibliography1. AdrianiOchsner JA: Some observations on the use of curare in the treatment of tetanus, Surgery 22: 509, 1947. MedlineGoogle Scholar2. GodmanAdriani HEJ (a) : Management of patients with various muscle-relaxing agents, J. A. M. A. 141: 754-756 (Nov. 22) 1949. (b) Santemma, E. E., and Graham, G. C.: Tolserol in tetanus, New York State J. Med. 50: 2731-2733 (Nov. 15) 1950. (c) Newhouse, M. L., Rochford, J. D., and Royston, G. R.: An unusual complication of Myanesin therapy in the treatment of tetanus, Brit. M. J. 2: 981-983 (Oct. 28) 1950. (d) Boles, T. C., and Smith, J. H.: Mephenesin in treatment of tetanus: results of oral administration in three cases, J. A. M. A. 146: 1296-1298 (Aug. 4) 1951. (e) Berger, F. M., and Bradley, W.: Muscle-relaxing action of Myanesin, Lancet 1: 97 (Jan. 18) 1947. (f ) Davidson, M. H. A., Ward, A. B., and Pask, E. A.: "Myanesin" in the treatment of tetanus, Brit. M. J. 1: 616 (Apr. 9) 1949. (g) Torrens, J. A., Edwards, P. M., and Wood, M. W. W.: Myanesin in tetanus, Lancet 2: 807 (Nov. 20) 1948. (h) Gammon, G. D., and Churchill, J. A.: Effects of Myanesin upon the central nervous system, Am. J. M. Sc. 217: 143 (Feb.) 1949. (i) MacDonald, W. B.: Case of severe tetanus treated with continuous intravenous infusion of "Myanesin" and Sodium Pentothal, M. J. Australia 2: 538, 1949. (j) Belfrage, D. H.: Tubocurarine in tetanus, Lancet 2: 889, 1947. CrossrefMedlineGoogle Scholar3. RichardsonMorrisonWalker APJLHA: Pharmacologic studies on Myanesin, Am. J. Med. 4: 465, 1948. CrossrefMedlineGoogle Scholar4. PughEnderly JIGE: Hemoglobinuria after intravenous Myanesin, Lancet 2: 387, 1947. CrossrefMedlineGoogle Scholar5. KositchekBarret RJGS: Abdominal pain and anemia due to Mephenesin, J. A. M. A. 143: 22 (May 6) 1950. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: *Received for publication July 13, 1953.From the Department of Medicine, University of Puerto Rico, School of Medicine, and the Department of Medicine, San Juan City Hospital. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byIntramuscular meprobamate in the treatment of tetanus in infants and childrenGENERALIZED TETANUS: ANALYSIS OF 202 CASES*MARIO R. GARCIA-PALMIERI, M.D., RICARDO RAMIREZ, M.D.The Management of TetanusManagement of tetanusCurrent pediatric references 1 March 1954Volume 40, Issue 3Page: 563-580KeywordsAsphyxiaChloridesConvulsionsHospital medicineHypoxiaMusclesParalysisRespiratory failureTetanus ePublished: 1 December 2008 Issue Published: 1 March 1954 PDF downloadLoading ...