EPIDIDYMITIS IN MUMPS, INCLUDING ORCHITIS: FURTHER CLINICAL STUDIES AND COMMENTS
Authors: S CANDEL
Journal: Annals of Internal Medicine (1951)

Article1 January 1951EPIDIDYMITIS IN MUMPS, INCLUDING ORCHITIS: FURTHER CLINICAL STUDIES AND COMMENTSSAMUEL CANDEL, M.D., F.A.C.P.SAMUEL CANDEL, M.D., F.A.C.P.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-34-1-20 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptOrchitis is a significant and common complication of mumps occurring after puberty. On the other hand, epididymitis as a frequent concomitant of the orchitis of mumps apparently has escaped the attention of many observers. Candel, Wheelock and Grimaldi1observed a case of mumps in which bilateral epididymitis preceded the appearance of bilateral orchitis by two days. This focused their attention upon the epididymis, and they concluded from a study of 105 cases of mumps, of which 23 developed orchitis, that epididymitis is frequently associated with orchitis. They felt that this was worth recording for two reasons: (1) All of the...Bibliography1. CandelWheelockGrimaldi SMCGJ: Mumps orchitis, U. S. Naval M. Bull. 45: 97-106, 1945. Google Scholar2. Waddelow JJ: Primary epididymitis in mumps, Brit. M. J. 1: 1480, 1909. MedlineGoogle Scholar3. Feiling A: Mumps—a critical review, Quart. J. Med. 8: 255-276, 1914-15. Google Scholar4. Madamet (2 cases); and Morel-Lavallée in 1848 (1 case) cited by Catrin11; Chauvin (2 cases) cited by Feiling.3 Google Scholar5. Smith GC: Two cases of orchitis due to mumps treated by operation, Boston M. and S. J. 167: 323-325, 1912. CrossrefGoogle Scholar6. Sorel M: Contribution à la thermométrie clinique de la fiévre dans l'orchite symptomatique des oreillons, Rev. mens. de méd. et de chir. 1: 280-288, 1877. Google Scholar7. Rambar AC: Pooled plasma treatment of mumps orchitis, U. S. Naval M. Bull. 42: 871-873, 1944. Google Scholar8. Rambar AC: Use of convalescent serum in the treatment and prophylaxis of orchitis, Am. J. Dis. Child. 71: 1-13, 1946. CrossrefMedlineGoogle Scholar9. Smith RG: Plasma treatment of orchitis: 5 cases, U. S. Naval M. Bull. 44: 159-160, 1945. Google Scholar10. Laveran A: Traité des maladies et des épidémies des armées, 1875, G. Masson, Paris, pp. 550-559. Google Scholar11. Catrin M: Orchite ourlienne, Bull. et mém. Soc. méd. d. hôp. de Paris 11: 108, 1894. Google Scholar12. Radin MJ: The epidemic of mumps at Camp Wheeler, Oct. 1917-March 1918, Arch. Int. Med. 22: 354-369, 1918. CrossrefGoogle Scholar13. RabinowitzSeligman MAB: Primary mumps orchitis without parotitis, M. J. and Rec. 130: 215-216, 1929. Google Scholar14. HarrisBethell WH: Meningo-encephalitis and orchitis as only symptoms of mumps, Lancet 2: 422, 1938. CrossrefGoogle Scholar15. DermonLe Hew HW: Mumps epidemic in a small task force, Am. J. M. Sc. 208: 240-247, 1944. CrossrefGoogle Scholar16. CandelWheelockTurkSmoot SMJJPJL: Mumps meningitis, U. S. Naval M. Bull. 42: 861-870, 1944. Google Scholar17. Thomson-Walker J: Diseases of the genito-urinary organs, Edited by Kenneth Walker, 1936, William Wood & Co., Baltimore, p. 858. Google Scholar18. GoodallWashbourn : Infectious diseases by E. W. Goodall, 3rd Ed., 1928, H. K. Lewis & Co., London, pp. 450-451. Google Scholar19. Boyd W: Surgical pathology, 6th Ed., 1947, W. B. Saunders Co., Philadelphia and London, p. 444. Google Scholar20. Cecil RL: Textbook of medicine, 7th Ed., 1947, W. B. Saunders Co., Philadelphia, p. 46. Google Scholar21. EisendrathRolnick DNHC: Urology, 1938, J. B. Lippincott Co., Philadelphia, p. 395. Google Scholar22. Le Comte RM: Manual of urology, 3rd Ed., 1944, Williams & Wilkins, Baltimore, p. 271. Google Scholar23. Christian HA: Oxford medicine, mumps, infectious diseases, Oxford University Press, New York, Vol. V, Part ii, p. 497. Google Scholar24. Abt IA: Pediatrics; mumps, 1925, W. B. Saunders Co., Philadelphia, p. 284. Google Scholar25. RollestonRonaldson JDGW: Acute infectious diseases, 3rd Ed., 1940, C. V. Mosby Co., St. Louis. Google Scholar26. Conybeare JJ: Textbook of medicine, 6th Ed., 1942, William Wood & Co., Baltimore, p. 37. Google Scholar27. Meakins JC: The practice of medicine, 4th Ed., 1944, C. V. Mosby Co., St. Louis, p. 97. Google Scholar28. Kers : Infectious diseases—a practical textbook, Revised by Claude Rundle and Humphrey Milford, 1929, Oxford University Press, London, p. 517. Google Scholar29. Campbell MF: Pediatric urology, 1937, The Macmillan Co., N. Y., Vol. 2, p. 113. Google Scholar30. Herman L: The practice of urology, 1938, W. B. Saunders Co., Philadelphia, pp. 663-664. Google Scholar31. Stimson PM: A manual of the common contagious diseases, 1947, Lea and Febiger, Philadelphia, p. 255. Google Scholar32. Musser JH: Internal medicine—its theory and practice, 4th Ed., 1945, Lea and Febiger, Philadelphia, p. 393. Google Scholar33. Osler's Principles and practice of medicine by Henry A. Christian, 16th Ed., 1947, D. Appleton-Century Co., New York and London, p. 352. Google Scholar34. Yater WM: Fundamentals of internal medicine, 2nd Ed., 1944, D. Appleton-Century Co., N. Y., p. 729. Google Scholar35. Fox MJ: Mumps, Practice of medicine, 1947, Edited by Tice, F., W. F. Prior, Hagerstown, Md., Vol. 3, p. 318. Google Scholar36. Top FH: Handbook of communicable diseases, 2nd Ed., 1947, C. V. Mosby Co., St. Louis, p. 512. Google Scholar37. HarriesMitman EHM: Clinical practice in infectious diseases, 1940, Williams and Wilkins Co., Baltimore, 228-229. Google Scholar38. Savill's System of clinical medicine, 12th Ed., 1944, Williams and Wilkins Co., Baltimore, pp. 601-602. Google Scholar39. Hinman F: Principles and practice of urology, 1935, W. B. Saunders Co., Philadelphia, p. 787. Google Scholar40. KeyesFerguson ELRS: Urology, 1936, D. Appleton-Century Co., N. Y., pp. 474 and 482. Google Scholar41. HelmolzAmbergHaynes HFSRS: Diseases of the genito-urinary system in infancy and childhood, 1930, D. Appleton & Co., New York, pp. 216 and 219. Google Scholar42. McCrea LE: Clinical urology, 1946, F. A. Davis Co., Philadelphia, p. 134. Google Scholar43. Cabot H: Modern urology, 3d Ed., 1936, Lea and Febiger, Philadelphia, Vol. 1, p. 483. Google Scholar44. OckerbladCarlson NFHE: Urology in general practice, 2nd Ed., 1947, The Year Book Publishers, Chicago, pp. 291 and 294. Google Scholar45. Pelouze PS: Office urology, 1940, W. B. Saunders Co., Philadelphia, pp. 414, 428-429. Google Scholar46. Hyman HT: An integrated practice of medicine, 1946, W. B. Saunders Co., Philadelphia, Vol. 3, p. 2461. Google Scholar47. Sterling C: The cyclopedia of medicine, surgery and specialties, George Morris Piersol, Editor, 1946, F. A. Davis Co., Vol. 14, 992-999. Google Scholar48. Roche AE: Urology in general practice, 1935, H. K. Lewis & Co., Ltd., London, pp. 303-308. Google Scholar49. Trousseau A: Lectures on clinical medicine, 1869, The New Sydenham Society, London, Vol. II, pp. 277-281. Google Scholar50. Boutelle JT: Cases of mumps complicated with epididymitis, Boston M. and S. J. 94: 384-386, 1876. CrossrefGoogle Scholar51. Phillips S: Note on a case of mumps in which attacks of epididymitis occurred on each side in turn, each attack being accompanied by symptoms profoundly involving the nervous system, Lancet 1: 23, 1911. CrossrefGoogle Scholar52. Wesselhoeft C: Orchitis in mumps, Boston M. and S. J. 183: 458-461, 1920. CrossrefGoogle Scholar53. Zax E: Mumps epididymo-orchitis without involvement of the salivary glands, with a case report, Urol. and Cutan. Rev. 41: 624, 1937. Google Scholar54. Zax E: Mumps epididymo-orchitis without salivary gland involvement: report of a second case, Urol. and Cutan. Rev. 47: 173, 1943. Google Scholar55. Hammersley A: Observations on cyanache parotidoea as it occurred in the N. Y. State Prison during winters of 1821 and 1822, N. Y. Med. Repository, July, 1822, 416-417. (Quoted by Wesselhoeft.52) Google Scholar56. Phares DL: Mumps metastases, Trans. Miss. M. A., Jackson, Mississippi 16: 114-115, 1883. Google Scholar57. Finkelstein H: Meningo-encephalitis in mumps, J. A. M. A. 3: 17-19, 1938. CrossrefGoogle Scholar58. Applebaum IL: Serum amylase in mumps, Ann. Int. Med. 21: 35-43, 1944. LinkGoogle Scholar59. CandelWheelock SMC: Serum amylase and serum lipase in mumps, Ann. Int. Med. 25: 88-96, 1946. LinkGoogle Scholar60. EndersCohenKane JFSLW: Immunity in mumps, J. Exper. Med. 81: 119-135, 1945. CrossrefMedlineGoogle Scholar61. StokesEndersMarisKane JJJFEPLW: Immunity in mumps—experiments on the vaccination of human beings with formolized mumps virus, J. Exper. Med. 84: 407-428, 1946. CrossrefMedlineGoogle Scholar62. De LavergneFlorentine VP: Convalescents' serum in prevention of orchitis in mumps, Bull. Acad. de méd., Paris 93: 362, 1925; Abstr. J. A. M. A. 84: 1701, 1925. Google Scholar63. Teissier : Prophylactic value of convalescents' serum in mumps, Bull. Acad. de méd., Paris 93: 369, 1925; Abstr. J. A. M. A. 84: 1701, 1925. Google Scholar64. Hinckley RG: Therapeutic use of convalescent serum in mumps, Minnesota Med. 20: 227, 1937. Google Scholar65. BaileyHaerem WHAT: Some observations on efficacy of convalescent mumps serum, Mil. Surgeon 90: 134-139, 1942. Google Scholar66. Enders JF: Chemical, clinical and immunological studies on the products of human plasma fractionation. X. The concentration of certain antibodies in globulin fractions derived from human blood plasma, J. Clin. Investigation 23: 510-531, 1944. CrossrefMedlineGoogle Scholar67. GellisMcGuinessPeters SSACM: A study of the prevention of mumps orchitis by gamma-globulin, Am. J. M. Sc. 210: 661-664, 1945. CrossrefGoogle Scholar68. Candel S: Immune serum globulin (gamma-globulin) in the prophylaxis of mumps orchitis, Mil. Surgeon 99: 199-202, 1946. MedlineGoogle Scholar69. Enders JF: Quoted by Gellis, S. S.67 Google Scholar70. Savran J: Diethylstilbestrol in the prevention of orchitis following mumps, Rhode Island M. J. 29: 662, 1946. MedlineGoogle Scholar71. NixonLewis NDB: Mumps orchitis, surgical treatment, J. Urol. 56: 554-560, 1946. CrossrefMedlineGoogle Scholar72. Hyman HT: An integrated practice of medicine, 1946, W. B. Saunders Co., Philadelphia, Vol. 3, p. 2464. Google Scholar73. Wesselhoeft C: Orchitis in mumps, Boston M. and S. J. 183: 520-524, 1920. CrossrefGoogle Scholar74. Bénard R: La sterileté, consècutive aux oreillons de l'adulte est un mythe, Médecine 9: 184-189, 1927. Google Scholar75. MichelsonMichelson LR: Fertility studies of the male in barren marriages, J. A. M. A. 134: 941-944, 1947. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Brooklyn, New York*Received for publication December 28, 1948.From the U. S. Naval Training Center, Gulfport, Mississippi.The views expressed herein are the opinions of the writer and not necessarily the views of the Bureau of Medicine and Surgery or the Navy at large. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byMolecular biology, pathogenesis and pathology of mumps virusMumps VirusClinical Features of Mumps Orchitis in Vaccinated Postpubertal Males: A Single-Center Series of 62 PatientsThe increasing incidence of mumps orchitis: a comprehensive reviewMumps Orchitis in the Post-Vaccine Era (1967-2009)Viral IllnessesMumps VirusMale genital tuberculosisMumpsMeasles, mumps and rubella - the urologist's perspectiveMumps VirusEntzündungen von Hoden, Nebenhoden, Samenstrang und HodenhüllenDisease and Infertility: a New Look at the Demographic Collapse of Native Populations in the Wake of Western ContactFertilität und Infektionskrankheiten*)Untersuchungen des Hodengewebes bei andrologischen Patienten mit Orchitis, Epididymitis und traumatischer Hodenschädigung in der AnamneseMyxovirenDie Bedeutung der Myxo-, Adeno-, Coxsackie-und Echo-Viren für die DermatologieMUMPS AND MALE FERTILITYMumps EpididymitisTreatment of Mumps Orchitis with ACTH and CortisoneI. Present Considerations 1 January 1951Volume 34, Issue 1Page: 20-36KeywordsMumpsOrchitisPubertySurgery ePublished: 1 December 2008 Issue Published: 1 January 1951 PDF downloadLoading ...