tbuckley/cabot-search huggingface dataset:
Third-Party Review Programs From the Blue Cross Vantage Point
Authors: fames M. Ensign
Journal: JAMA (1966)

Although utilization review has been underscored by WP.L. 89-97, the subject is certainly by no means new to many physicians or to voluntary systems in general, or Blue Cross in particular. On the contrary, provisions relating to utilization review activity and many other provisions as well in the law are a direct reflection of the fact that these processes have been around long enough to have shown themselves as valuable tools for the development of knowledge, understanding, and progress among physicians, hospitals, third parties, patients, and the various publics. As a subject for national attention and activity, formal utilization and review programs are comparative newcomers to the scene, particularly when one considers the state of the art and the science and the literature. The First National Conference on Utilization, sponsored by the American Hospital Association, the Blue Cross Association, the American Medical Association, and the National Association of Blue Shield
On Disregarding Findings That Cannot Explain the Syndrome
Authors: Walter C. Alvarez
Journal: New England Journal of Medicine (1953)

IN these days when so many physicians are looking to the laboratory worker, the roentgenologist and the specialist for most of their diagnoses, one of the most sorely needed courses in every medical school is one on the art of disregarding findings that turn up during many an examination but are not producing the symptoms and cannot possibly explain the whole syndrome presented by the patient.That this instruction is badly needed today would be obvious to anyone who came and sat for a week alongside me at my desk. Often the condition reported by the patient's physician is present, . . .
The effect of triethylene glycol dimethacrylate on the cell cycle of mammalian cells
Authors: Helmut Schweikl, Inge Altmannberger, Nico Hanser, Karl-Anton Hiller, Carola Bolay, Gero Brockhoff, Gianrico Spagnuolo, Kerstin Galler, Gottfried Schmalz
Journal: Biomaterials (2004)
Career choices of trainees in general practice
Authors: R. Webb, D. Hannay
Journal: BMJ (1996)

but zygosity has no effect on the risk of disease for either male (P=0-23) or female twins (P=0-63).John A Davis's points about environmental factors such as infection and diet are important.In fact, in our paper we argued against uncritical use of estimates of heritability and for in depth studies of concordance according to zygosity and the co-occurrence of immunological markers and susceptibility genes.Davis's points about monozygotic twins being reared differently from dizygotic twins and being of a lower birth weight would imply a higher prevalence of disease in monozygotic than dizygotic twins.However, we have found exactly the same prevalence of disease in monozygotic and dizygotic twins, similar to that in the general population.
Abstract LB-218: Profiling kinase inhibition in cancer cell extracts using active-site probes and targeted high resolution, accurate mass spectrometry
Authors: Ryan D. Bomgarden, Scott M. Peterman, Rosa I. Viner, Michael M. Rosenblatt, Chris L. Etienne, John C. Rogers
Journal: Cancer Research (2011)

Abstract Protein kinases are enzymes that play key roles in signal transduction pathways which regulate cellular processes including growth, division, differentiation and metabolism. Kinase inhibitors are essential tools used by researchers to understand kinase function and are also therapeutic compounds used in treating cancer and other diseases. Active-site probes are one technology that can be used to determine the specificity and potency of kinase inhibitors. Desthiobiotin-ATP and -ADP are two nucleotide derivatives that have been shown to selectively label kinase active sites. Using these probes to enrich kinase active-site peptides, we identified over 150 kinases from K562 chronic myelogenous leukemia and A549 lung carcinoma cell extracts using high resolution, accurate mass (HR/AM) spectrometry. We also assessed specificity of kinase inhibitors including staurosporine and wortmannin by determining the relative quantitation of kinase active-site peptides after drug treatment. In addition, we validated kinase inhibitor targets using a parallel Western blot workflow. Overall, kinase inhibition measured using high resolution, accurate mass spectrometry had strong correlation with Western blot data and enabled global profiling of kinase inhibitor target and off-targets. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 102nd Annual Meeting of the American Association for Cancer Research; 2011 Apr 2-6; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2011;71(8 Suppl):Abstract nr LB-218. doi:10.1158/1538-7445.AM2011-LB-218
Digitalis-induced augmentation of cardiopulmonary baroreflex control of forearm vascular resistance.
Authors: T Imamura, A Takeshita, T Ashihara, K Yamamoto, S Hoka, M Nakamura
Journal: Circulation (1985)

We sought to determine whether digitalis augments cardiopulmonary baroreflex control of forearm vascular resistance in normal young men. Cardiopulmonary baroreceptor input was reduced with lower body negative pressure (LBNP) at 10 and 20 mm Hg, which decreased central venous pressure but did not alter blood pressure or heart rate. Decreases in forearm blood flow and increases in forearm vascular resistance with LBNP were greater after administration of lanatoside C (Cedilanid) than before, and the slope of the regression line relating changes in central venous pressure and those in forearm vascular resistance was steeper after lanatoside C. Vasoconstrictor responses to the cold pressor test did not differ before and after lanatoside C, which suggested that augmented responses to LBNP after the drug were not caused by a generalized change in reflex control. These results suggest that lanatoside C augments the tonic inhibitory influence of cardiopulmonary baroreceptors in normal men.
Total Anomalous Pulmonary Venous Connection
Authors: GARY E. GATHMAN, ALEXANDER S. NADAS
Journal: Circulation (1970)

Experience with 75 cases of proven total anomalous pulmonary venous connection without other significant cardiac malformations treated at the Children's Hospital Medical Center in Boston from January 1950 to June 1968 forms the basis of this report. Clinical observations of patients with this defect presenting in infancy are reviewed in depth, and the few patients presenting after 1 year of age are included to give a spectrum of this disease in the pediatric age group. Chest x-rays and complete electrocardiograms were available in each case. Sixty-one patients had partial or complete cardiac catheterizations. The anatomic and physiologic data from these studies are presented, and the results of medical management are evaluated. On the basis of the physiologic data, an approach to management is proposed which includes early operative intervention in those patients with pulmonary vascular obstruction. If pulmonary hypertension is present without vascular obstruction, medical management may be tried. If pulmonary hypertension is not present and particularly if there is a significant gradient across the right ventricular outflow tract, medical management appears to be the treatment of choice until operative intervention can be undertaken with less operative mortality.
Interferons — Expanding Therapeutic Roles
Authors: Ernest C. Borden
Journal: New England Journal of Medicine (1992)

Just over a decade ago, interferon alfa-2 produced by recombinant-DNA technology was introduced into clinical trials. An American Cancer Society initiative, which had confirmed the antitumor activity of leukocyte interferon laboriously produced from units of donated blood, and the subsequent venture-capital investment by the infant biotechnology industry generated substantial interest among physicians and in the lay press. The degree of media attention led to expectations among the public, investors, and the medical community that this family of human proteins with broad antiviral activity and modulatory effects on pleiotropic cells might be wonder drugs like penicillin. When initial clinical trials of . . .
High CD33-antigen loads in peripheral blood limit the efficacy of gemtuzumab ozogamicin (Mylotarg®) treatment in acute myeloid leukemia patients
Authors: V H J van der Velden, N Boeckx, I Jedema, J G te Marvelde, P G Hoogeveen, M Boogaerts, J J M van Dongen
Journal: Leukemia (2004)
Protein-losing enteropathy in dermatitis herpetiformis
Authors: ANTHONY D. TOFT, ROBERT C. HEADING, JOHN SIMPSON
Journal: British Journal of Dermatology (1973)

Journal Article Protein‐losing enteropathy in dermatitis herpetiformis Get access ANTHONY D. TOFT, ANTHONY D. TOFT Departments of Therapeutics and Medical Physics, The Royal Infirmary, Edinburgh EH3 9YW Search for other works by this author on: Oxford Academic Google Scholar ROBERT C. HEADING, ROBERT C. HEADING Departments of Therapeutics and Medical Physics, The Royal Infirmary, Edinburgh EH3 9YW Search for other works by this author on: Oxford Academic Google Scholar JOHN SIMPSON JOHN SIMPSON Departments of Therapeutics and Medical Physics, The Royal Infirmary, Edinburgh EH3 9YW Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 89, Issue 3, 1 September 1973, Pages 233–236, https://doi.org/10.1111/j.1365-2133.1973.tb02969.x Published: 01 September 1973 Article history Accepted: 10 March 1973 Published: 01 September 1973
Capacity building model for increased access to quality cardiac care for children in underserved regions
Authors: Bistra Zheleva, Andreas Tsakistos, Erin Murley, Emily Dale
Journal: The Lancet Global Health (2014)

BackgroundCongenital heart anomalies are the most common major birth defect in the world, affecting one in every 120 children, 90% of whom live where medical care is inadequate or unavailable. Increased access to paediatric cardiac care is a priority for most low-income and middle-income countries today. Children's HeartLink is dedicated to increasing access and improving quality at paediatric cardiac centres by use of a collaborative model that fosters sustainable clinical, organisational, and community capacity.MethodsChildren's HeartLink works in India, China, Brazil, Malaysia, Ukraine, and Vietnam. The programme delivery model supports development of self-sustaining paediatric cardiac centres of excellence by using a three-phase approach of training and mentoring partnerships between developed and developing world programmes. Metrics in areas of clinical skills improvement, multidisciplinary teamwork, and administrative systems demonstrate progress towards becoming a sustainable regional centre of excellence, culminating in designation as a Children's HeartLink Global Partner in Pediatric Cardiac Care. Partner hospitals report clinical outcomes to Children's HeartLink; clinical and organisational competency is tracked through medical volunteer feedback.FindingsMarkers of improved partner site outcomes include reduced mortality and morbidity, increased patient volume, and improved interdisciplinary communication, resulting in superior clinical judgment and decision making. This capacity-building model has resulted in one partner becoming a Global Partner in Pediatric Cardiac Care and Training and two becoming Global Partners in Pediatric Cardiac Care.InterpretationQuantitative and qualitative analysis has shown that this capacity-building model leads to sustainable, accessible, and improved quality paediatric cardiac care in low-income and middle-income countries, and can be replicated in other health-care areas.FundingNone.
An Evaluation of the Respiratory and Sedative Effects of Meperidine Hydrochloride Combined with Levallorphan Tartrate in Postoperative Patients
Authors: Robert Megirian, Chester W. White
Journal: New England Journal of Medicine (1957)

PREVIOUS reports from this hospital have shown the value of combining levallorphan tartrate with alpha-prodine (Nisentil) hydrochloride in controlling the respiratory-depressant effects of the latter in post-operative patients.1 , 2 In view of the favorable effect of combining levallorphan§ with alpha-prodine, a study of its actions in combination with meperidine was undertaken. Meperidine is widely employed as a narcotic analgesic, its efficacy being generally recognized. It has the disadvantage of producing respiratory depression, like other narcotics,3 4 5 and its intravenous use occasionally causes cardiovascular depression or collapse6 , 7; its properties are not as benign as was originally believed. Recent studies have indicated that . . .
Christmas at Guy's
Authors: John P. Merrill
Journal: New England Journal of Medicine (1957)

TO the untutored eye of the American visitor the first view of Guy's Hospital affords little to suggest the wealth of tradition it embodies. Looking down from the London Bridge approach through the wet mist of a November morning, one sees the northeast entry, much as it appeared in the architect's plan of 1734. The east wing of the court, however, has been destroyed by bombing, and its shattered skeleton is only partially enclosed by temporary building. Across the street, where once stood Guy's sister school, St.Thomas's, a new office building has been erected, and foundations for another are . . .
SOME CAUSES OF WRY-NECK.
Authors: C. M. HOBBY
Journal: JAMA (1898)

The object of this paper is to report facts, leaving the consideration of their bearing upon the condition commonly known as wry-neck, for the future. The writer does not believe that disturbances of the nervous equilibrium, which in a few isolated cases are relieved by successful treatment of peripheral irritation, are to be considered as the result of that special irritation. As in epilepsy we occasionally have apparent cure, by correction of the refraction, or by some form of treatment of so-called muscular imbalance, as well as by operating for phimosis, and as the same measures have frequently been followed by the cessation of chorea, so in the following instances torticollis has recovered, after the removal of ocular conditions, apparently little more likely to have exerted a causative influence in its production. That there is nothing original in this suggestion, is shown by a remark in Vol. vii, p. 557,
Immunohistochemical demonstration of amyloid P component in skin of normal subjects and patients with cutaneous amyloidosis
Authors: S.M. BREATHNACH, B. BHOGAL, R.F. DYCK, F.C. BEER, M.M. BLACK, M.B. PEPYS
Journal: British Journal of Dermatology (1981)

Journal Article Immunohistochemical demonstration of amyloid P component in skin of normal subjects and patients with cutaneous amyloidosis Get access S.M. BREATHNACH, S.M. BREATHNACH Institute of Dermatology, St John's Hospital for Diseases of the Skin, Lisle Street, Leicester Square, London WC2H 7BJ Search for other works by this author on: Oxford Academic Google Scholar B. BHOGAL, B. BHOGAL Institute of Dermatology, St John's Hospital for Diseases of the Skin, Lisle Street, Leicester Square, London WC2H 7BJ Search for other works by this author on: Oxford Academic Google Scholar R.F. DYCK, R.F. DYCK Institute of Dermatology, St John's Hospital for Diseases of the Skin, Lisle Street, Leicester Square, London WC2H 7BJ Search for other works by this author on: Oxford Academic Google Scholar F.C. DE BEER, F.C. DE BEER Immunological Medicine Unit, Department of Medicine, Royal Postgraduate Medical School, Hammersmith Hospital, Ducane Road, London Wl2 oHS Search for other works by this author on: Oxford Academic Google Scholar M.M. BLACK, M.M. BLACK Institute of Dermatology, St John's Hospital for Diseases of the Skin, Lisle Street, Leicester Square, London WC2H 7BJ Search for other works by this author on: Oxford Academic Google Scholar M.B. PEPYS M.B. PEPYS Immunological Medicine Unit, Department of Medicine, Royal Postgraduate Medical School, Hammersmith Hospital, Ducane Road, London Wl2 oHS M.B.Pepys. Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 105, Issue 2, 1 August 1981, Pages 115–124, https://doi.org/10.1111/j.1365-2133.1981.tb01195.x Published: 01 August 1981 Article history Accepted: 09 February 1981 Published: 01 August 1981
The Nuclear Receptor ERRα Is Required for the Bioenergetic and Functional Adaptation to Cardiac Pressure Overload
Authors: Janice M. Huss, Ken-ichi Imahashi, Catherine R. Dufour, Carla J. Weinheimer, Michael Courtois, Atilla Kovacs, Vincent Giguère, Elizabeth Murphy, Daniel P. Kelly
Journal: Cell Metabolism (2007)
Remarkable Case of Complicated Pregnancy: Miscarriage at Six Months
Authors: F. C. G. Ellerton
Journal: BMJ (1875)

Feb. I3, i875.-ht body should for a molmient be exposed to cold, or for some other equally cogenlt or perhaps unknownii reason, the separation is mysteri- ously accomplished.It is better to avoid such subtegumentary pro- ceedinlgs, involving as they do the expenditure of critical time and a r-isk of the mutilation of a peniis or a finger; and also if it be wished p io prevent that bane of infant wvell-doing, "atelectasis pulmonum'.It may be expected that something should be said about the binder.I have little to say, except in its condemnation, if used for the purpose of restraining uterinie haxmorrhage.If appliedl when the uterus is well cooti-acted, it is useless; if wheni relaxed, it will be injurious by cover- nlg oxver and concealing the source of danger.Its great use is as a sur >,ical appliance in giving support to the relaxed abdominal parietes, iccurli their equable adaptation to the abdominal contenits, and thus Cmcilltating their contractioni and timely involution.On this account, it scither Nvell nor fitting to pull the patient about, when quiet is so -enssetial, t3 adapt the nicely made banidage.An easily applied slip is 1' t-at is needful for the first twenty-four hours.1 y conviction is that the bandage should be continued for at least a amonth after each confinement, if we are anxious to preserve the normal -clation of the axis of the uterus to that of the pelvis, and so prevent -delay and danger at subsequent confinements ; or if we desire to avoid le unseemly production of a pendulous belly.Let cases be stripped of the accidents, largely avoidable, which we have been considering, and how miiany remain to be dealt wvith ?Only those unforeseen and un- a-voidable cases of peculiar hxemorrhage, dependent on idiosyncrasy, ex- Amnples of which were so well and so courageously related by Mr. Crisp at our last meeting.In such cases, it is niot to be expected that remedies having a reflex ')lperation slhould be of all avail; more immediate and direct means nust be employed, as the hand to the internal surface and the introduc- ion of various substances into the cavity of the uterus.I say introduc- tion, not injection.When, in the induction of premature labour the injection of water alone has proved fatal, I think wve should be cautious how we inject flui(ds which may prove fatal not only in that wvay, but by 2ea.ion of their engendering septic emic sequelh.Besides, the styptic 1luid needs only to be applied to the surface of the uterus, and should not permeate the sinuses.It will have been seen that principles rather than practice, except in
Clinical Studies on the Action of Bemegride in Barbiturate Overdosage
Authors: T. J. Thomson
Journal: BMJ (1958)

BIThe foregoing is likely to be oversimplified, for improved analysis may reveal new protein fractions and functions.Hypersensitivity and immune response to tuberculosis may then be found to be shared by leucocytes (and other body cells) and some serum protein fraction other than y-globulin.In short, there may be some combined function of leucocytes and serum proteins.The door is open to a more comprehensive conception of the immunology of tuberculosis.Summary A case of acquired hypogammaglobulinaemia, active pulmonary tuberculosis, and epilepsy is reported, and reference is made to the other recorded cases of hypogammaglobulinaemia associated with tuberculosis.It is submitted that the association of hypogammaglobulinaemia and tuberculosis is coincidental, and that they bear no aetiological relationship one to the 'other.The natural course of tuberculous disease appears to be unaffected by hypogammaglobulinaemia, and delayed hypersensitivity and immune response are normal in patients observed to date.It is suggested that delayed hypersensitivity and serum antibody response to tuberculosis function inde- pendently of y-globulin, and may rely on a cellular mechanism (leucocytes and other body cells), though the possibility of an unidentified serum protein fraction sharing such immunological powers is not excluded.I thank Drs. K. R. Stokes and L. E.
Health-related quality of life, depression, and anxiety in patients with autoimmune hepatitis
Authors: Christoph Schramm, Inka Wahl, Christina Weiler-Normann, Katharina Voigt, Christiane Wiegard, Claudia Glaubke, Elmar Brähler, Bernd Löwe, Ansgar W. Lohse, Matthias Rose
Journal: Journal of Hepatology (2013)
Endoscopic Nd:YAG Laser Therapy in Patients with Early Superficial Carcinoma of the Esophagus and the Gastric Cardia
Authors: G. R. Yang, L. Q. Zhao, S. S. Li, S. L. Qiu, Y. M. Wang, J. H. Jia
Journal: Endoscopy (1994)

A group of 33 patients, 27 with early superficial esophageal cancer and six with early superficial carcinoma of the gastric cardia, were treated with endoscopic neodymium:yttrium aluminum garnet (Nd:YAG) laser from April 1989 to March 1993. Of the 33 patients, in 32 (97%) the disappearance of the cancer cells was noted. They were treated 1-6 times (average 2.6) with laser irradiation. No serious complications, such as perforation, occurred in the series. Twenty-two patients were followed up for 24-55 months. A negative biopsy was recorded in 16 (72.7%) of the 22 patients; the other six (27.3%) cases were found to have recurrent early cancer during the follow-up period from the 36th to the 40th months, and were treated with supplementary endoscopic therapy or surgical resection. It is suggested that endoscopic Nd: YAG laser may be a safe and effective therapy for early carcinoma of the esophagus and the gastric cardia, when the risks of surgery are too high or the patient has refused surgical resection.
Rural Medicine/Urban Responsibilities
Authors: Joel H. Lanphear
Journal: JAMA (1986)

In this issue ofTHE JOURNAL, Knopke et al<sup>1</sup>report successful outcomes from "Bio-Prep: A Premedical Program for Rural High School Students." The project, designed to help and motivate disadvantaged but talented students from rural Alabama consider careers in the health professions, shows great promise for increasing the number of qualified minority applicants. Project students performed significantly higher than matched nonproject students on the American College Testing Program entrance examination and chose professional and health-related careers earlier and more frequently than matched nonprogram students.<sup>1</sup> This program represents a positive response to decreasing minority enrollments in the health professions and to shortages of physicians in rural areas of the South and intermountain West. The significance of such programs has far-reaching implications for major medical education institutions, which are essentially urban based. Black Americans constituted 11.7% of the country's population in 1980 but only 3.1% of the nation's physicians. First-year
Points: The flight from science
Authors: E K Ledermann
Journal: BMJ (1980)

Thank you for your interest in spreading the word about The BMJ.NOTE: We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail. We do not capture any email address. Username * Your Email * Send To * You are going to email the following Points: The flight from science Your Personal Message CAPTCHA This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.