The Treatment of Severe Staphylococcal Infections with Vancomycin
Authors: DONALD W. WOODLEY
Journal: Annals of Internal Medicine (1961)

Article1 August 1961The Treatment of Severe Staphylococcal Infections with VancomycinDONALD W. WOODLEY, M.D., WENDELL H. HALL, M.D., PH.D., F.A.C.P.DONALD W. WOODLEY, M.D., WENDELL H. HALL, M.D., PH.D., F.A.C.P.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-55-2-235 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe efficacy of vancomycin (Vancocin®—Lilly) in the treatment of severe staphylococcal infections is becoming well established. According to several authors it is now the agent of choice if the organism is penicillin-resistant (1-3). Vancomycin has a bactericidal action for staphylococci, and as yet no resistant strains have been reported in clinical practice. Toxicity is often bothersome, but it is rarely serious or a cause for discontinuing therapy. A summary of our experience with this drug in 25 cases of serious staphylococcal infections will be presented, along with a review of the literature on vancomycin. The following cases are reported in...References1. GERACIHEILMAN JEFR: Vancomycin in the treatment of staphylococcal endocarditis. Proc. Mayo Clin. 35: 316, 1960. MedlineGoogle Scholar2. KIRBYPERRYBAUER WMDMAW: Treatment of staphylococcal septicemia with vancomycin: report of thirty-three cases. New Engl. J. Med. 262: 49, 1960. CrossrefMedlineGoogle Scholar3. PETERSDORFROSEMINCHEWKEENEBENNETT RGMCHBWRIL: The sensitivity of hemolytic staphylococci to a series of antibiotics. Arch. Intern. Med. 105: 398, 1960. CrossrefMedlineGoogle Scholar4. ELLIOTTHALL HJWH: Studies on synergism with twelve antibiotics against thirty hospital strains of Staphylococcus aureus. J. Lab. Clin. Med. 50: 242, 1957. MedlineGoogle Scholar5. 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CrossrefMedlineGoogle Scholar22. WALLACECARSON IRNA: Staphylococcal septicemia treated with vancomycin in the presence of chronic renal failure. Lancet 1: 519, 1960. CrossrefMedlineGoogle Scholar23. GERACIHEILMANNICHOLSWELLMAN JEFRDRWE: Antibiotic therapy of bacterial endocarditis: VII. Vancomycin for acute micrococcal endocarditis: preliminary report. Proc. Mayo Clin. 33: 172, 1958. MedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: DONALD W. WOODLEY, M.D.; WENDELL H. HALL, M.D., PH.D., F.A.C.P.Affiliations: Minneapolis, MinnesotaReceived for publication February 20, 1961.From the Veterans Administration Hospital, Minneapolis, Minnesota, and the Department of Medicine, University of Minnesota Medical School.Supported by a grant from Eli Lilly and Co., Indianapolis, lnd.Requests for reprints should be addressed to Wendell H. Hall, M.D., Chief, Medical Service, Veterans Administration Hospital, 54th St. and 48th Ave. South, Minneapolis 17, Minn. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byAntibiotic-Associated Diarrhea Beyond C. 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MERRILL, M.D., ALVIN DAVIS, M.D., BERNARD SMOLENS, M.D., SYDNEY M. FINEGOLD, M.D., F.A.C.P.The Treatment of Staphylococcal Infection with Nafcillin with a Discussion of Staphylococcal NephritisBRUCE C. NYDAHL, M.D., WENDELL H. HALL, M.D., F.A.C.P.The Treatment of Staphylococcal InfectionsThe Newer Penicillins II. Clinical Experiences with Methicillin and OxacillinHAROLD J. SIMON, M.D., PH.D., LOWELL A. RANTZ, M.D., F.A.C.P.Studies on the Antibiotic Therapy of Serious Staphylococcal Infections I. Comparison of the In Vitro Activity of Methicillin, Phenethicillin, and Other AntibioticsF. ROBERT FEKETY JR., M.D., LEIGHTON E. CLUFF, M.D.The Diagnostic Dilemma of Severe Staphylococcal InfectionsROBERT I. WISE, M.D., PH.D. 1 August 1961Volume 55, Issue 2 Page: 235-249 Keywords Drugs Endocarditis Enterocolitis Hospital medicine Osteomyelitis Sepsis Staphylococcal infection Toxicity Urea Vancomycin ePublished: 1 December 2008 Issue Published: 1 August 1961 PDF downloadLoading ...