tbuckley/cabot-search huggingface dataset:
Frail Older Adults and Palliative Care
Authors: Thomas E. Finucane
Journal: JAMA (2007)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Apnea in Premature Infants and Incubator-Air-Temperature Changes
Authors: Paul H. Perlstein, Neil K. Edwards, James M. Sutherland
Journal: New England Journal of Medicine (1970)

The thermal events associated with apneic spells-were recorded during the monitoring of selected premature infants housed in incubators controlled by servo mechanism to maintain skin temperature between 35.8 and 36.6°C. The temperature changes that occurred during the 120 seconds before the onset of apnea were compared to the changes measured exactly 15 minutes before each episode. Of the 126 apneic spells 70 occurred during a rise, 44 during a fall, and 12 during a plateau (no change) in air temperature. During the nonapneic control periods, there were 41 rises, 64 falls and 21 plateaus in temperature. The onsets of apnea, therefore, were preceded by rising air temperatures more commonly (p less than 0.001) than matched moments without apnea. This correlation, supported by dramatic examples of apnea with sudden increases in air temperature, adds to the evidence that present incubator thermal control may help trigger apnea.
Somatic Mosaicism of CIAS1 in a Patient with Chronic Infantile Neurologic, Cutaneous, Articular Syndrome
Authors: M. Saito, R. Nishikomori, A. Fujisawa, N. Kambe, M.N. Hizume, I. Okafuji, T. Yoshioka, M. Yoshimoto, K. Omori, T. Kusunoki, T. Heike, Y. Miyachi, T. Nakahata
Journal: Journal of Allergy and Clinical Immunology (2006)
Cell-mediated Immune Responses in Chronic Liver Diseases
Authors: M. G. M. Smith, P. L. Golding, A. L. W. F. Eddleston, C. G. Mitchell, A. Kemp, R. Williams
Journal: BMJ (1972)

Studies of the cell-mediated response to liver antigens, using the leucocyte migration test, in 163 patients with various liver disorders showed that abnormal responses were almost confined to active chronic hepatitis (53% abnormal), primary biliary cirrhosis (64%), and cryptogenic cirrhosis (29%). The test was also abnormal in five out of seven patients with jaundice due to drug hypersensitivity and in one patient with acute infectious hepatitis at a time when mitochondrial antibodies were present in the serum. More of those with active chronic hepatitis on prednisone or azathioprine had normal tests than of those who were untreated, and in 8 out of 10 examined serially during therapy there was an accompanying improvement in leucocyte migration. Abnormal responses to salivary gland or kidney antigens were also found in nearly half of those with features of Sjögren's syndrome or renal tubular acidosis as part of a multisystem involvement-this, though occurring in cryptogenic cirrhosis, was found with greater frequency in active chronic hepatitis and primary biliary cirrhosis. These cell-mediated immune responses, perhaps triggered by the initial damage to the liver from viral or other agents, may be responsible both for the perpetuation of the liver disease and, because of common surface antigens, for the damage to other organs.
The Allocation and Rationing of High-Cost Services
Authors: Cory Franklin
Journal: JAMA (1986)

<h3>To the Editor.—</h3> The conclusions drawn by the authors of the article entitled "Rationing of Intensive Care Unit Services"<sup>1</sup>that physicians effectively ration intensive care beds are inadequately supported by the data presented. As the authors note, "the nature of our study yielded no information about potential poor outcomes for patients never admitted to the ICU [intensive care unit]." Without such information, the total effect of rationing cannot be evaluated. Data from our institution lead us to a diametrically opposite conclusion. In 1983, we expanded our medical critical care 20-bed service by creating a 12-bed intermediate care unit and redirecting lower-risk patients to this area. Twelve months before and 18 months after the intermediate care unit opened, our data indicated that the ICU mortality did not change with the expansion of services (23.5 ±3.94 per 100 admissions to the ICU before to 23.6 ± 3.77 after opening the intermediate
A chemical biology screen identifies glucocorticoids that regulate c-maf expression by increasing its proteasomal degradation through up-regulation of ubiquitin
Authors: Xinliang Mao, A. Keith Stewart, Rose Hurren, Alessandro Datti, Xuegong Zhu, Yuanxiao Zhu, Changxin Shi, Kyle Lee, Rodger Tiedemann, Yanina Eberhard, Suzanne Trudel, Shengben Liang, Seth J. Corey, Lisa C. Gillis, Dwayne L. Barber, Jeffery L. Wrana, Shereen Ezzat, Aaron D. Schimmer
Journal: Blood (2007)
Neovascularization in Biodegradable Inverse Opal Scaffolds with Uniform and Precisely Controlled Pore Sizes
Authors: Sung‐Wook Choi, Yu Zhang, Matthew R. MacEwan, Younan Xia
Journal: Advanced Healthcare Materials (2012)

The formation of a stable vascular network in a scaffold is one of the most challenging tasks in tissue engineering and regenerative medicine. Despite the common use of porous scaffolds in these applications, little is known about the effect of pore size on the neovascularization in these scaffolds. Herein is fabricated poly(D, L-lactide-co-glycolide) inverse opal scaffolds with uniform pore sizes of 79, 147, 224, and 312 μm in diameter and which are then used to systematically study neovascularization in vivo. Histology analyses reveal that scaffolds with small pores (<200 μm) favor the formation of vascular networks with small vessels at high densities and poor penetration depth. By contrast, scaffolds with large pores (>200 μm) favor the formation of vascular networks with large blood vessels at low densities and deep penetration depth. Based on the different patterns of vessel ingrowth as regulated by the pore size, a model is proposed to describe vascularization in a 3D porous scaffold, which can potentially serve as a guideline for future design of porous scaffolds.
Refining Ventilatory Treatment for Acute Lung Injury and Acute Respiratory Distress Syndrome
Authors: Luciano Gattinoni
Journal: JAMA (2008)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Spinal cord degeneration in a case of "recovered" spinal decompression sickness.
Authors: A C Palmer, I M Calder, R I McCallum, F L Mastaglia
Journal: BMJ (1981)

Degeneration in the spinal cord of goats after experimental decompression sickness is well documented but opportunities to examine the long-term effects in man are rare. We describe severe damage in the spinal cord of a man who had made an almost complete functional recovery from spinal decompression sickness.
Reply to Alexander S. Parker, Brad C. Leibovich, Jeanette E. Eckel-Passow, John C. Cheville's Letter to the Editor re: Samira A. Brooks, A. Rose Brannon, Joel S. Parker, et al. ClearCode34: A Prognostic Risk Predictor for Localized Clear Cell Renal Cell Carcinoma. Eur Urol 2014;66:77–84
Authors: W. Kimryn Rathmell, Samira A. Brooks, Joel S. Parker, Matthew E. Nielsen
Journal: European Urology (2014)
TREATMENT OF PEPTIC ULCER-Reply
Authors: George F. Dick
Journal: JAMA (1942)

<h3>To the Editor:—</h3> The only reason the physiologic principles governing the treatment of gastric and duodenal ulcers were not discussed more extensively in our article inThe Journalwas that of brevity. We thought that the important thing was to record the facts and results rather than to give theoretical explanations for them. However, the remarks are both interesting and pertinent, and we would have no doubt of the importance of inhibition by enterogastrone of gastric mobility and acidity in the treatment of ulcer.
Effect of Early Multifactorial Therapy Compared With Routine Care on Microvascular Outcomes at 5 Years in People With Screen-Detected Diabetes: A Randomized Controlled Trial
Authors: Annelli Sandbæk, Simon J. Griffin, Stephen J. Sharp, Rebecca K. Simmons, Knut Borch-Johnsen, Guy E.H.M. Rutten, Maureen van den Donk, Nicholas J. Wareham, Torsten Lauritzen, Melanie J. Davies, Kamlesh Khunti
Journal: Diabetes Care (2014)

To determine the benefit of multifactorial treatment on microvascular complications among people with type 2 diabetes detected by screening.This study was a multicenter cluster randomized controlled trial in primary care with randomization at the practice level. In four centers in Denmark; Cambridge, U.K.; the Netherlands; and Leicester, U.K., 343 general practices participated in the trial. Eligible for follow-up were 2,861 of the 3,057 people with diabetes detected by screening included in the original trial. Biomedical data on nephropathy were collected in 2,710 (94.7%) participants, retinal photos in 2,190 (76.6%), and questionnaire data on peripheral neuropathy in 2,312 (80.9%). The prespecified microvascular end points were analyzed by intention to treat. Results from the four centers were pooled using fixed-effects meta-analysis.Five years after diagnosis, any kind of albuminuria was present in 22.7% of participants in the intensive treatment (IT) group and in 24.4% in the routine care (RC) group (odds ratio 0.87 [95% CI 0.72-1.07]). Retinopathy was present in 10.2% of the IT group and 12.1% of the RC group (0.84 [0.64-1.10]), and severe retinopathy was present in one patient in the IT group and seven in the RC group. Neuropathy was present in 4.9% and 5.9% (0.95 [0.68-1.34]), respectively. Estimated glomerular filtration rate increased between baseline and follow-up in both groups (4.31 and 6.44 mL/min, respectively).Compared with RC, an intervention to promote target-driven, intensive management of patients with type 2 diabetes detected by screening was not associated with significant reductions in the frequency of microvascular events at 5 years.
Effects of levosimendan on coronary artery flow and cardiac performance in patients with advanced heart failure
Authors: Ignatios Ikonomidis, John T. Parissis, Ioannis Paraskevaidis, Kallirrhoe Kourea, Vasiliki Bistola, John Lekakis, Gerasimos Filippatos, Dimitrios Th. Kremastinos
Journal: European Journal of Heart Failure (2007)
Interaction of lactoferrin, monocytes, and T lymphocyte subsets in the regulation of steady-state granulopoiesis in vitro.
Authors: G C Bagby, V D Rigas, R M Bennett, A A Vandenbark, H S Garewal
Journal: Journal of Clinical Investigation (1981)

Colony-stimulating activities (CSA) are potent granulopoietic stimulators in vitro. Using clonogenic assay techniques, we analyzed the degree to which mononuclear phagocytes and T lymphocytes cooperate in the positive (production/release of CSA) and feedback (inhibition of CSA production/release) regulation of granulopoiesis. We measured the effect of lactoferrin (a putative feedback regulator of CSA production) on CSA provision in three separate assay systems wherein granulocyte colony growth of marrow cells from 22 normal volunteers was stimulated by (a) endogenous CSA-producing cells in the marrow cells suspension, (b) autologous peripheral blood leukocytes in feeder layers, and (c) medium conditioned by peripheral blood leukocytes. The CSA-producing cell populations in each assay were varied by using cell separation techniques and exposure of isolated T lymphocytes to methylprednisolone or to monoclonal antibodies to surface antigens and complement. We noted that net CSA production increased more than twofold when a small number of unstimulated T lymphocytes were added to monocyte cultures. Lactoferrin's inhibitory effect was also T lymphocyte dependent. The T lymphocytes that interact with monocytes and lactoferrin to inhibit CSA production are similar to those that augment CSA production because their activities are neither genetically restricted not glucocorticoid sensitive, and both populations express HLA-DR (Ia-like) and T3 antigens but not T4 or T8 antigens. These findings are consistent with results of our studies on the mechanism of lactoferrin's inhibitory effect with indicate that mononuclear phagocytes produce both CSA and soluble factors that stimulate T lymphocytes to produce CSA, and that lactoferrin does not suppress monocyte CSA production, but does completely suppress production or release by monocytes of those factors that stimulate T lymphocytes to produce CSA. We conclude that mononuclear phagocytes and a subset of T lymphocytes exhibit important complex interactions in the regulation of granulopoiesis.
Review: Exercise reduces mortality compared with drugs in stroke but not in CHD, HF, or prediabetes
Authors: John F. Cox III
Journal: Annals of Internal Medicine (2014)

ACP Journal Club15 April 2014Review: Exercise reduces mortality compared with drugs in stroke but not in CHD, HF, or prediabetesJohn F. Cox III, MDJohn F. Cox III, MDUniversity of Rochester School of Medicine, Rochester, New York, USA (J.F.C.)Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-160-8-201404150-02003 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail Source CitationNaci H, Ioannidis JP. Comparative effectiveness of exercise and drug interventions on mortality outcomes: metaepidemiological study. BMJ. 2013;347:f5577. https://pubmed.ncbi.nlm.nih.gov/24473061Clinical Impact RatingsGIM/FP/GP: Endocrinology: Reference1 Lian XQ, Zhao D, Zhu M, et al. The influence of regular walking at different times of day on blood lipids and inflammatory markers in sedentary patients with coronary artery disease. Prev Med. 2014;58:64-9. [PMID: 24201089] Google Scholar Author, Article, and Disclosure InformationAuthors: John F. Cox III, MDAffiliations: University of Rochester School of Medicine, Rochester, New York, USA (J.F.C.)This article was published at Annals.org on 1 April 2014. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 15 April 2014Volume 160, Issue 8 Page: JC3 Keywords Congenital heart disease Diuretics Drugs Exercise Health economics Heart failure Mortality Network analysis Odds ratio Stroke ePublished: 15 April 2014 Issue Published: 15 April 2014 Copyright & PermissionsCopyright © 2014 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Effect of thyroid hormone on the expression of mRNA encoding sarcoplasmic reticulum proteins.
Authors: M Arai, K Otsu, D H MacLennan, N R Alpert, M Periasamy
Journal: Circulation Research (1991)

The purpose of this study was to determine the expression of genes encoding various sarcoplasmic reticulum components that are functionally coupled with calcium release, uptake, and storage function during cardiac hypertrophy induced by thyroid hormone. Hyperthyroidism was induced in two groups of rabbits by the injection of 200 micrograms/kg L-thyroxine (T4) daily for 4 days (T4-4-day group) and 8 days (T4-8-day group). Hypothyroidism was induced in another group of rabbits by adding 0.8 mg/ml propylthiouracil to the drinking water for 4 weeks. The relative expression level of mRNA encoding different sarcoplasmic reticulum proteins was determined by RNA slot blot and Northern blot analysis. In hyperthyroid hearts, the steady-state level of cardiac ryanodine receptor mRNA and sarcoplasmic reticulum cardiac/slow-twitch Ca(2+)-ATPase mRNA were both increased to 147% (T4-4-day group) and 186% (T4-8-day group) of control, respectively, but decreased to 71% and 75%, respectively, in hypothyroid ventricles. The mRNA level for phospholamban was decreased in both hyperthyroidism (T4-8-day group, 72%) and hypothyroidism (77%) in these hearts. On the other hand, calsequestrin mRNA levels did not change in hyperthyroid and hypothyroid ventricles. In accord with the changes in Ca(2+)-ATPase mRNA levels, the Ca(2+)-ATPase protein was increased to 199% (T4-8-day group) in hyperthyroid ventricles and decreased to 86% of control in hypothyroid ventricles. The expression levels of ryanodine receptor, Ca(2+)-ATPase, phospholamban, and calsequestrin mRNAs were similarly altered in skeletal muscle tissues from hyperthyroid and hypothyroid rabbits. These results indicate that the mRNA levels of sarcoplasmic reticulum proteins responsible for calcium release and calcium uptake are coordinately regulated in response to changes in thyroid hormone level in both heart and skeletal muscle. These changes in mRNA level should lead to changes in protein levels and thus to altered calcium release and uptake in the chronic stages of hyperthyroidism and hypothyroidism.
The Practice of Psychiatry in General Hospitals
Authors: E. E. LANDIS
Journal: American Journal of Psychiatry (1958)

This book is based upon a symposium on "The Nature and Actions of the Internal Secretions of the Pancreas" which was held in London, England, from the 21st to the 23rd of June 1955.It is truly an international c9llection of famous names in chemistry, physics and the biological sciences.The subject material in general consists of fundamental research such as reports on the destruction of pancreas cells by chemical means, and the metabolic effects so pro- duced.Several chapters are devoted to very technical dis- cussions on fractionation of insulin, the chemical structure and the three dimensional structure of insulin.Metabolic effects of insulin are presented such as the effect upon the permeability of tissue cells to sugars, effect on transport of sugars, and hepatic action.An excellent review and discussion, as well as original work on glucagon is presented, including its chemical and biological characteristics and metabolic effects.It is work such as this which may lead to eventual improvement in the treatment of diabetes and other disturbances of carbo- hydrate metabolism.This book is not for the general practitioner or general internist.It is very valuable for those who are doing basic research on the pancreas and for those who are doing clini- cal research in this field.The chapters on glucagon are stimulating and give rise to new avenues for clinical in- vestigation.
Drug company payments to doctors still hard to access despite disclosure laws
Authors: Fred Charatan
Journal: BMJ (2007)

UK NEWS UK Biobank gets 10% response rate as it starts recruiting volunteers, p659 World NEWS US �u�ge bans use o�� ter�� �lig�t cigarette�� �orl��i�e, p65� US �u�ge bans use o�� ter�� �lig�t cigarette�� �orl��i�e
Issues relating to abortions are complicated in Nigeria
Authors: I. Mohammed
Journal: BMJ (2003)

EDITOR—Raufu's news item drawing attention to Nigeria, where 20 000 deaths are reported to occur every year as a result of mostly illegal abortions, calls for definite remedial action.1 I commend the dean of the medical school at Benin University and the Society for Gynaecology and Obstetrics in Nigeria for drawing attention yet again to this important cause of morbidity …
CONTROL STUDY OF THALIDOMIDE (KEVADON), A NEW HYPNOTIC AGENT
Authors: H. AZIMA, DOROTHY ARTHURS
Journal: American Journal of Psychiatry (1961)

1. Kevadon, in short term hypnotic effect, is equal to, if not more adequate than, phenobarbital; 2. It seems—and this has to be confirmed with more detailed studies—that Kevadon has less after or "hang over" effect than phenobarbital; 3. It seems to be difficult to produce a prolonged state of sleep with Kevadon; 4. If further control trials substantiate these conclusions, Kevadon will become a valuable hypnotic substance.
Health Information during a Week of Television
Authors: Frank A. Smith, Geoffrey Trivax, David A. Zuehlke, Paul Lowinger, Thieu L. Nghiem
Journal: New England Journal of Medicine (1972)

Abstract A commercial-network television channel in Detroit was monitored during a typical 130-hour broadcast week. Health-related content used 7.2 per cent of the time. Only 30 per cent of this health time offered useful information, and 70 per cent of the health material was inaccurate or misleading or both. Television programming did not use the educational capacity of the health professions to any notable extent. There were 10 times as many television messages that urged the use of pills or other remedies as there were against drug use or abuse. Although some useful health information was offered, the major health problems such as heart disease, cancer, stroke, accidents, hepatitis, maternal death, hunger, venereal disease, mental health, sex education, child care, lead poisoning and family planning were virtually ignored during the television week.
Intrapulmonary percussive ventilation in tracheostomized patients: a randomized controlled trial
Authors: Enrico M. Clini, Francesca Degli Antoni, Michele Vitacca, Ernesto Crisafulli, Mara Paneroni, Sheila Chezzi-Silva, Maurizio Moretti, Ludovico Trianni, Leonardo M. Fabbri
Journal: Intensive Care Medicine (2006)
Etiology of Scarlet Fever.
Authors: W. P. Howle
Journal: JAMA (1891)

<h3>Journal of A.M.A.—Dear Sir:</h3> In your last issue you say you will take pleasure in publishing communications on cases like the following, and as it will probably be of some value in the etiology of scarlet fever, I will report it. Six weeks ago yesterday.Chattie Myers, aged 10 years, went to Morley, a village four miles from this place and was in a room for an hour in which another little girl was suffering with scarlet fever. The little girl had been sick three days. Chattie came home and just two weeks afterwards was taken down with the disease, was quite sick and is now just about through the shedding process; her parents have kept the different portions of skin and have handsful of it in the shape of fingers, toes, etc., and during this week Chattie is bloated and threatened with a severe attack of uremia. So there is