tbuckley/cabot-search huggingface dataset:
THE RELATION OF INDICANURIA AND OXALURIA TO GASTRO-INTESTINAL FERMENTATION.
Authors: J. A. WESENER
Journal: JAMA (1901)

The object of treating such a large subject in one article is, if possible, to determine if there is a relationship between the excreted indican and oxalic acid, and the bearing these bodies have on gastro-intestinal fermentations. Harnack1has shown most conclusively that when oxalic and sulphuric acids are given to dogs per stomach or per os, indicanuria is produced, the sulphuric acid producing not so intense an indican reaction as when oxalic acid is used. He further shows that the subcutaneous injection of even .06 gram of sodium oxalate is followed by indicanuria. He raises the question whether indicanuria is associated with pathologic oxaluria. This is one of the questions which I have tried to solve. The putrefactive bases are formed in the small intestines and are known as indol, skatol and phenol. They are also often spoken of as the aromatic compounds. By the action of the pancreatic
Flt3 Signaling-Dependent Dendritic Cells Protect against Atherosclerosis
Authors: Jae-Hoon Choi, Cheolho Cheong, Durga B. Dandamudi, Chae Gyu Park, Anthony Rodriguez, Saurabh Mehandru, Klara Velinzon, In-Hyuk Jung, Ji-Young Yoo, Goo Taeg Oh, Ralph M. Steinman
Journal: Immunity (2011)
Do it their way
Authors: B Dixon
Journal: BMJ (1994)

This month, a decalogue of advice for scientists on how (not) to write up their research.

1.  Never consult Instructions to Authors, which are actually printed for the guidance of the journal's editors. Many of these will be young people just out of university, and need to be reminded about conventions with which you, a distinguished contributor, having lifelong familiarity.

2.  There is no longer any need to check either the form or accuracy of your references. One of the benefits of modern information technology is that everything, from the dates and titles of journals to authors' names, can now be corrected automatically. No more trekking down to the library.

3.  If the …
<i>Flower Still Life</i>
Authors: Jeanette M. Smith
Journal: JAMA (2014)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Unanswered Questions — Drug-Eluting Stents and the Risk of Late Thrombosis
Authors: William H. Maisel
Journal: New England Journal of Medicine (2007)

Unanswered Questions — Drug-Eluting Stents and the Risk of Late Thrombosis By the end of 2004, drug-eluting stents were used in nearly 80% of percutaneous coronary interventions in the United States, and within 3 years, several million drug-eluting stents had been implanted worldwide. Dr. William Maisel writes that, unfortunately, much remains uncertain about the long-term safety of the devices.
Treatment of Bacterial Endocarditis with Cephalosporin Derivatives in Penicillin-Allergic Patients
Authors: Michael A. Apicella, Robert L. Perkins, Samuel Saslaw
Journal: New England Journal of Medicine (1966)

BACTERIAL endocarditis was almost universally fatal before the advent of antibiotics.1 , 2 The poor prognosis radically improved in the 1940's with the availability of penicillin.3 To date, penicillin remains the single most effective antibiotic agent for the treatment of endocarditis due to gram-positive cocci.4 Unfortunately, approximately 2 per cent of the general population are allergic to penicillin.5 Furthermore, an estimated 18 per cent of adults with rheumatic or congenital heart lesions susceptible to endocarditis who have received regular prophylactic courses of penicillin may be allergic to the antibiotic.6 In the past, 3 principal methods of therapy were available to patients allergic . . .
Molecular Alterations in Pleomorphic Lobular Carcinoma In Situ (PLCIS) of the Breast.
Authors: M. Chivukula, A. Brufsky, G. Carter, U. Chandran, M. Lyons-Weiler, D. Dabbs
Journal: Cancer Research (2009)

Abstract Introduction: Pleomorphic lobular carcinoma in situ (PLCIS) is a rare distinct variant of lobular carcinoma in situ (LCIS) which is morphologically difficult to distinguish from high-grade ductal carcinoma in situ (DCIS). We performed microarray DNA analysis to characterize the genetic changes of this entity in order to determine if such changes were unique to PLCIS.Materials and Methods: 5 Pleomorphic (4 in situ and 1 invasive) and 4 normal non-paired breast tissues were analyzed for copy number changes using the Affymetrix 250K Sty array. Copy Number (CN) changes were detected by the Partek (Partek Inc, St Louis, MI) software. Data processing steps included GC content correction and segmentation to determine regions of amplifications and deletions.Results: Each sample demonstrated a unique pattern of CN changes with amplifications being more frequent than deletions, and between 25 and 66 changes per sample. Chromosomes 1, 11, 14, 16 and 8 exhibit the most frequent changes. Large deletions in chromosome 16q were seen in 4 out of 5 samples and amplification of regions of 1q in 4 out of 5 samples. Focal common amplifications, defined as less than 100kb in length, CN&amp;gt;5 and present in at least 3 samples, were seen in a number of regions including 8q23.1 containing the NUDCD1 gene (5/5 samples), 14q23.3 containing the GPHN (3/5 samples) gene, 12p12.2 containing the gene SLCO1B3 (3/5 samples), and 4p16.1.Discussion: Our results indicate that changes on chromosomes 1, 11, 14, 16 and 8 are frequently observed in pleomorphic lobular carcinoma (PLC) as well as PLCIS. Deletions in chromosome 16q and amplification of regions of 1q seen in our cases are associated with loss of e-cadherin and β-catenin expression and are the characteristic genetic abnormalities seen in classic lobular carcinoma. In addition, the characteristic 8q23.1, 14q23.3 and 12p12.2 reported in high grade DCIS were seen in our cases as well. PLCIS exhibits overlapping features with both classical lobular neoplasa and high grade DCIS. Citation Information: Cancer Res 2009;69(24 Suppl):Abstract nr 5004.
Mohs' micrographic surgery for treatment of basal cell carcinoma of the face--results of a retrospective study and review of the literature
Authors: N.W.J. Smeets, D.I.M. Kuijpers, P. Nelemans, J.U. Ostertag, M.E.J.M. Verhaegh, G.A.M. Krekels, H.A.M. Neumann
Journal: British Journal of Dermatology (2004)

The incidence of skin cancer and especially basal cell carcinoma (BCC) has increased in the last decade and is still increasing. Many treatment modalities can be used to treat BCC; surgical excision is the most frequently used. Mohs' micrographic surgery (MMS) is an advanced excision technique which is often used to treat BCC in the U.S.A. In Europe it is practised less frequently.The aim of this article was to evaluate the efficiency of MMS for the treatment of facial BCC.In a retrospective study recurrence rates after the treatment of facial BCC by MMS were estimated by reviewing the records of all patients with BCCs (620 patients with 720 BCCs) treated by MMS in our department from April 1992 until December 1999.The 5-year recurrence rates estimated from this study were 3.2% for primary BCC and 6.7% for recurrent BCC. Prognostic factors for recurrence are: an aggressive histopathological subtype, more than four Mohs' stages, a large defect size and a recurrent BCC.Based on the fact that MMS provides the lowest recurrence rates, it is the treatment of first choice for primary facial BCCs with an aggressive histopathological subtype and for recurrent BCCs in the face.
Reentrant Arrhythmias in the Subacute Infarction Period
Authors: Mark Restivo, Hong Yin, Edward B. Caref, Archana I. Patel, Gjin Ndrepepa, Matthew J. Avitable, Mahshid A. Assadi, Nidal Isber, Nabil El-Sherif
Journal: Circulation (1995)

Background The Cardiac Arrhythmia Suppression Trial has shown that flecainide was associated with an increased incidence of sudden cardiac death in postinfarction patients. The exact mechanism(s) of the proarrhythmic effects of flecainide remain unclear. We performed a detailed analysis of the electrophysiological and proarrhythmic effects of flecainide in a well-characterized model of reentrant arrhythmias in the subacute phase of myocardial infarction. Methods and Results Sixteen dogs were studied 4 days after ligation of the left anterior descending coronary artery. Isochronal mapping of ventricular activation showed that flecainide facilitated both the induction and sustenance of ventricular tachycardia, especially at shorter basic cycle lengths. Flecainide had negligible effect on the length of the arc of functional conduction block but markedly depressed conduction of the common reentrant wave front that was usually oriented parallel to fiber axis. Whole heart mapping was analyzed in combination with basic measurements of the effects of flecainide on conduction and refractory properties of both normal and ischemic myocardia using a high-resolution cross electrode consisting of four orthogonal arms, each comprised of 16 poles with an interelectrode spacing of 500 μm. The electrode was especially designed to study the effects of the drug on anisotropic conduction as determined by a linear regression of activation time and distance in each direction. Flecainide resulted preferentially in more marked rate-dependent depression of conduction in ischemic compared with normal myocardium. On the other hand, the effect of flecainide on refractoriness in both normal and ischemic myocardia was negligible. Conclusions Because flecainide caused no significant change in refractoriness in both normal and ischemic myocardia, there was no difference in the dimension of the potential reentrant pathway, that is, the continuous line of functional conduction block, around which the reentrant wave fronts circulate. Yet, flecainide resulted in significant rate-dependent slowing of conduction preferentially in ischemic myocardium. The additional slowing of conduction of the common reentrant wave front coupled with minimal changes in the length of the reentrant pathway allowed additional time for the wave front to reexcite normal myocardium on the proximal side of the arc of block. After flecainide, reentry could be induced in hearts in which reentry could not be induced during control. The same proarrhythmic mechanism explains the propensity of nonsustained figure-8 reentrant tachycardias to become sustained after flecainide.
Monocyte Chemoattractant Protein-1 but Not Tumor Necrosis Factor-α Is Correlated With Monocyte Infiltration in Mouse Lipid Lesions
Authors: Jill Reckless, Edward M. Rubin, Judy B. Verstuyft, James C. Metcalfe, David J. Grainger
Journal: Circulation (1999)

Background —Apolipoprotein (apo)(a) transgenic mice and C57BL/6 mice fed a high fat diet develop similar-sized lipid lesions, but lesions in apo(a) mice are devoid of macrophages. We used this observation to identify which proinflammatory proteins might be involved in mediating monocyte recruitment during atherogenesis. Methods and Results —Macrophage-deficient apo(a) transgenic mouse lesions contained similar levels of several different proinflammatory proteins, both adhesion molecules (intercellular adhesion molecule-1 [ICAM-1] and vascular cell adhesion molecule-1 [VCAM-1]) and cytokines (tumor necrosis factor-α [TNF-α] and macrophage inflammatory protein-1α [MIP-1α]), similar to the macrophage-rich lesions of C57BL/6 mice. Conclusions —From this we conclude that ICAM-1, VCAM-1, TNF-α, and MIP-1α may all be necessary for vascular monocyte recruitment in vivo, but they cannot be sufficient. Monocyte chemoattractant protein-1 (MCP-1) protein was undetectable in the vessel wall taken from apo(a) transgenic mice fed a high fat diet compared with high expression in mice with lipid lesions (C57BL/6 and apoE knockout mice). Therefore elevated expression of MCP-1 but not TNF-α, MIP-1α, ICAM-1, or VCAM-1 is correlated with vascular macrophage accumulation. To test the hypothesis that monocyte infiltration during atherogenesis is MCP-1 dependent, it will be necessary to develop specific pharmacological inhibitors of MCP-1 activity.
Management of severe ovarian hyperstimulation.
Authors: A J Tyack, J D Ellis
Journal: BMJ (1971)

<b>An important phenotypic change is associated with human asthma: the protein expression of both isoforms of Rho-kinase, ROCK1 and ROCK2, is increased in the smooth muscles of intra-parenchymal airways and in the pulmonary blood vessels</b>http://bit.ly/2pPfyxH
Therapies for Cancer in Children — Past Successes, Future Challenges
Authors: Robert E. Wittes
Journal: New England Journal of Medicine (2003)

Of the many things that physicians do, participating in cooperative clinical trials is among the strangest. Relatively undervalued in the typical academic promotion-and-tenure process, often inadequately reimbursed by government funding agencies, faced with informed-consent regulations that vastly exceed in degree of disclosure what is required for routine care, and confronting progressively greater degrees of regulation with each passing year, the clinical trialist may be forgiven for occasionally wondering whether society really wants this kind of work to go forward.In the end, however, it does go forward. Some of the fuel for the engine is a stream of products from . . .
The price of life
Authors: Brendan D Kelly, Sharon R Foley
Journal: BMJ (2007)

On 31 January 2006 Jaime Elizalde Junior, a 34 year old Hispanic man, was executed by lethal injection in Texas. Elizalde, a welder, had been convicted of killing two men in Houston in the mid-1990s. He spent eight years on death row before being given an injection of thiopental sodium (to sedate him), pancuronium bromide (to collapse his lungs and diaphragm), and potassium chloride (to stop his heart beating). The injection cost $86.08 (£42; €60).

In 2005 at least 2148 people were executed and another 5186 were sentenced to death in various countries around the world. Four countries were responsible for 94% of executions: China, Iran, Saudi Arabia, and the United States. A variety of methods were used, including hanging, firing squad, beheading, and lethal injection. Those put to death included adults, children, and individuals with intellectual disabilities. The prevalence of psychological distress and mental illness is high among prisoners on death row, who may have to wait for more than 20 years for their death sentence to be carried out.

In Texas the average time spent on death row is just over 10 …
A NOVEL METHOD OF USING STRYCHNIN AND HYDRASTIN IN SEXUAL AND VESICAL WEAKNESS.
Authors: WILLIAM J. ROBINSON
Journal: JAMA (1906)

usually have to deal with acute affections of the stomach and bowel, or of both organs, produced by overfeeding with too greasy or too heavy food.In these cases the dietetic treatment must be directed especially against the acute affections and we must leave the diabetes out of consideration.A bland meager diet is the main thing (beef tea, gruels, milk, possibly raw eggs beaten up in milk or beef tea).When the acute stage of the digestive dis- turbances-is passed we can slowly return to the anti- diabetic diet. DISCUSSION.Dr. Heinrich Stern, New York City, speaking of the oat- meal cure of von Noorden, Mosse's potato cure and the milk cure, said that everybody knows that milk contains from 4 to 5 per cent, of lactose, which the diabetic organism can burn up only in the rarest of instances.In these few instances, of course, milk may be administered in quantities sufficient to maintain the nitrogen balance.In the ease of at least 95 per cent, of all diabetics the ingestion of lactose, on the other hand, will increase the amount of glucose output.Mosse's potato cure is merely an imitation of von Noorden's scheme.Such dietary regulation may be indicated in certain eases of chronii glycosuria, or in certain phases of diabetes, but to recommeno them for every diabetic at all times is, Stern said, illogical as well as nonsensical.He declared that it is extremely irrational for von Noorden to give his oatmeal together with 250 or 300
Editorial: Multiple sclerosis: explanations of cause
Authors: H. H. Hussey
Journal: JAMA (1976)

In years past (possibly even now), a standard textbook of medicine would begin, "Multiple sclerosis is a disease of unknown cause characterized by..." (a brief definition of the disease would follow at this point). Two facts about multiple sclerosis (MS) have led students of the disease to speculate about two possible causes. First, MS occurs mainly in northern latitudes, and the occasional appearance of more than one case within families suggested to some scholars that an infectious agent is basic to the disorder. This idea was strengthened by the demonstration that other demyelinating diseases of the central nervous system (CNS) (Kuru, a disease endemic in New Guinea; Creutzfeldt-Jacob disease; subacute sclerosing panencephalitis; and progressive multifocal leukoencephalopathy) had been shown to be caused by viruses and had been placed firmly in the category of slow virus diseases. Second, the same observations of familial groupings of MS cases and its geographic localization
Serum levels of soluble Fas antigen in chronic hepatitis C patients
Authors: Sadaharu Iio, Norio Hayashi, Eiji Mita, Keiji Ueda, Kiyoshi Mochizuki, Naoki Hiramatsu, Kanto Tatsuya, Yutaka Sasaki, Akinori Kasahara, Masatsugu Hori
Journal: Journal of Hepatology (1998)
Noradrenalin vs terlipressin in patients with hepatorenal syndrome: A prospective, randomized, unblinded, pilot study
Authors: C. Alessandria, A. Ottobrelli, W. Debernardi-Venon, L. Todros, M. Torrani Cerenzia, S. Martini, F. Balzola, A. Morgando, M. Rizzetto, A. Marzano
Journal: Journal of Hepatology (2007)
Sympathetic innervation modulates ventricular impulse propagation and repolarisation in the immature rat heart
Authors: L. S Sun, M. J Legato, T. S Rosen, S. F Steinberg, M. R Rosen
Journal: Cardiovascular Research (1993)

When cardiac sympathetic innervation in neonatal rats is retarded by antiserum to nerve growth factor, there is a corresponding increase in the QT interval on ECG. Since the propagation of the cardiac impulse and the repolarisation of cardiac cells both contribute to the QT interval, the aim of this study was to determine the role of sympathetic innervation in modulating ventricular impulse propagation and repolarisation.Neonatal rats were treated for the first 10 days of life with nerve growth factor (NGF), its antiserum (As), or placebo. Standard microelectrode techniques were used to study the transmembrane action potential characteristics of subendocardial (ventricular septal) and subepicardial ventricular myocardium. Bipolar surface electrograms were used to record the velocity of impulse propagation and electron microscopy to examine the intercalated discs.In the subendocardium, the phase 0 upstroke velocity of the action potential (dV/dtmax) was lowest in the As treated rats. The latter group also showed the slowest conduction velocity. There were no differences in control action potential durations in the endocardium among the three groups, but in the epicardial tissues, action potential duration was longest in the As treated group. Thus the dispersion in action potential duration was smallest in the As treated animals. Electron microscopic studies of the intercalated discs of ventricular myocytes showed significant enhancement of nexal junction formation in NGF treated rats, whereas As treated animals showed a retarded pattern of both nexal and desmosomal junction formation.The differences in ultrastructure, conduction, and repolarisation seen in As and NGF treated animals may explain the prolonged QT interval seen in the As treated group.
Stroke After Coronary Artery Bypass Graft Surgery
Authors: Ye Fan
Journal: JAMA (2011)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Macrophage-Derived AIM Is Endocytosed into Adipocytes and Decreases Lipid Droplets via Inhibition of Fatty Acid Synthase Activity
Authors: Jun Kurokawa, Satoko Arai, Katsuhiko Nakashima, Hiromichi Nagano, Akemi Nishijima, Keishi Miyata, Rui Ose, Mayumi Mori, Naoto Kubota, Takashi Kadowaki, Yuichi Oike, Hisashi Koga, Maria Febbraio, Toshihiko Iwanaga, Toru Miyazaki
Journal: Cell Metabolism (2010)
TCTAP A-087 Percutaneous Left Atrial Appendage Occlusion Can Be Performed Under Conscious Sedation Without General Anaesthesia
Authors: Ngai-Yin Chan, Chi-Chung Choy, Chun-Leung Lau, Ping-Tim Tsui, Ying-Keung Lo, Pui-Shan Chu, Ho-Chuen Yuen, Hoi-Fan Chow, Ho-Fai Fong, Lok-Hang Ng, Ngai-Shing Mok
Journal: Journal of the American College of Cardiology (2014)
Recovery of Pulmonary Arterial Blood Flow in Patients with Pulmonary Embolism
Authors: Donald E. Tow, Henry N. Wagner
Journal: New England Journal of Medicine (1967)

ALTHOUGH the acute hemodynamic effects of massive pulmonary embolism1 and the sequelae of chronic obstruction of major pulmonary arteries2 have been defined, little is known about the rate of restoration of pulmonary arterial blood flow in acute pulmonary embolism. Recently, Sauter and his associates3 used angiography in 2 patients to document complete resolution of emboli within twenty-five and a hundred and twenty-eight days. Fred et al.4 reported similar findings in 7 patients. Technical complexity and the possible hazards of pulmonary arteriography have prevented its widespread application in serial studies of patients with pulmonary embolism. A clearer understanding of the natural . . .