Clinical Interpretation of Jaundice Based on Physiologic Principles
Authors: I. W. Held, Milton Kramer
Journal: Annals of Internal Medicine (1932)

Article1 August 1932Clinical Interpretation of Jaundice Based on Physiologic PrinciplesI. W. HELD, M.D., F.A.C.P., MILTON KRAMER, M.D.I. W. HELD, M.D., F.A.C.P.Search for more papers by this author, MILTON KRAMER, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-6-2-207 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe tremendous value in diagnosis of bed-side approach, based on a large clinical experience is known to all. In many disease states, this suffices, and memory of characteristic symptoms, physical findings and laboratory data makes accurate diagnosis possible. The problem is not so simple in diseases associated with jaundice, a leading symptom that all may recognize easily, but which is due to so many conditions, intra- and extra-hepatic, that extreme difficulty often arises in interpretation. Here, experience alone, plus the most exact functional tests known, fails to lead to exact diagnosis in a vast number of cases. Notwithstanding painstaking reasoning...References1 ROSENTHAL F: Die Bedeutung des Elastins beim Ikterus, Klin. Wchnschr., 1930, ix, 1909-1913. CrossrefGoogle Scholar2 VIRCHOW R: Die pathologischen Pigmente, Arch. f. path. Anat. u. Physiol. u. f. klin. Med., 1847, i, 379-491. CrossrefGoogle Scholar3 MINKOWSKINAUNYN OB: Beiträge zur Pathologie der Leber und des Icterus, Arch. f. exper. Path. u. Pharmakol., 1886, xxi, 1-33. CrossrefGoogle Scholar4 LÖWIT M: Beiträge zur Lehre vom Icterus, Beitr. z. path. Anat. u. z. allg. Path., 1889, iv, 225-264. Google Scholar5 MCNEE JW: Experiments on hemolytic icterus, Jr. Path. and Bact., 1913-14, xviii, 325-342. Google Scholar6 WHIPPLEHOOPER GHCW: Icterus; a rapid change of hemoglobin to bile pigment in circulation outside the liver, Jr. Exper. Med., 1913, xvii, 612-635. Google Scholar7 RICH AR: Formation of bile pigments, Physiol. Rev., 1925, v, 182-224. CrossrefGoogle Scholar8 MAKINO J: Beiträge zur Frage der anhepatocellulären Gallenfarbstoffbilding, Beitr. z. path. Anat., u. z. allg. Path., 1924, lxxii, 808-859. Google Scholar9 MANN FC: Relation of the liver to metabolism, Harvey Lect., 1927-28, Ser. xxiii, Williams and Wilkins Company, Baltimore, 49-75. Google Scholar10 ROSENTHALMELCHIORLICHT FEH: Untersuchungen am leberlosen Säugetier, Arch. f. exper. Path. u. Pharmakol., 1925, cvii, 238-259. Google Scholar11 JOANNOVICSPICK GE: Beitrag zur Kenntnis der Toluylendiaminvergiftung, Ztschr., f. exper. Path. u. Therap., 1910, vii, 185-214. Google Scholar12 KODAMA M: Beiträge zur Pathogenese des Ikterus, Beitr. z. path. Anat. u. z. allg. Path., 1925, lxxiii, 187-250. Google Scholar13 HALDEMANN KO: A histologic study of formation of bile pigment, Arch. Path., 1929, vii, 993-1011. Google Scholar14 ERNSTSZAPPANYOS ZB: Untersuchungen über extrahepatogene Gallenfarbstoffbildung an überlebenden Organen, Biochem. Ztschr., 1925, clvii, 16-29. Google Scholar15 KOMORIIWAONAKAMURA YCH: Über die Bilirubinbildung der Überlebenden normalen Milz, Jr. Biochem., 1928. viii, 195-204. Google Scholar16 LEPEHNE G: Pathogenese des Ikterus, Ergebn. d. inn. Med. u. Kinderh., 1921, xx, 221-280. Google Scholar17 EPPINGER H: Ikterus, Neue deutsch. Klin., 1930, v, 274-303. Google Scholar18 ROLLESTONMCNEE HJW: Diseases of liver, gall bladder and bile ducts, 1929, Macmillan Company, New York, 568. Google Scholar19 STUBER B: Klinische Physiologie, 1927, J. F. Bergmann, München, 263. CrossrefGoogle Scholar20 RICH AR: (Quoted by Barron No. 22). Google Scholar21 RICH AR: Pathogenesis of forms of jaundice, Bull. Johns Hopkins Hosp., 1930, xlvii, 338-377. Google Scholar22 BARRON ES: Bilirubinemia, Med., 1931, x, 77-133. Google Scholar23 MCMASTERELMAN PDR: Urobilin physiology and pathology, Ann. Int. Med., 1927, i, 68-73. Google Scholar24 BERGMANN G: Zur Funktionellen Pathologie der Leber insbesondere der Alkohol-Aetiologie der Cirrhose, Klin. Wchnschr, 1927, vi, 776-780. CrossrefGoogle Scholar25 EILBOTT W: Funktionsprüfung der Leber mittels Bilirubinbelastung, Ztschr., f. klin. Med., 1927, cvi, 529-558. Google Scholar26 HARROPBARRON GAES: The excretion of intravenously injected bilirubin as a test of liver function, Jr. Clin. Invest., 1931, ix, 577-587. CrossrefGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: I. W. HELD, M.D., F.A.C.P.; MILTON KRAMER, M.D.Affiliations: New York City*Beth Israel Hospital, New York City.†Received for publication, October 18, 1931. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 August 1932Volume 6, Issue 2 Page: 207-217 Keywords Memory Reasoning Research laboratories ePublished: 1 December 2008 Issue Published: 1 August 1932 PDF downloadLoading ...