PSEUDOMONAS BACTEREMIA: REVIEW OF NINETY-ONE CASES
Authors: James A. Curtin, Robert G. Petersdorf, Ivan L. Bennett
Journal: Annals of Internal Medicine (1961)

Article1 June 1961PSEUDOMONAS BACTEREMIA: REVIEW OF NINETY-ONE CASESJAMES A. CURTIN, M.D., ROBERT G. PETERSDORF, M.D., IVAN L. BENNETT JR., M.D., F.A.C.P.JAMES A. CURTIN, M.D., ROBERT G. PETERSDORF, M.D., IVAN L. BENNETT JR., M.D., F.A.C.P.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-54-6-1077 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptINTRODUCTIONFor several reasons, the role of bacteria of thePseudomonasgroup in human disease has received increasing attention in recent years.1-5Antimicrobial drugs have reduced morbidity and mortality from many infections and have virtually eliminated several common pathogenic microorganisms as major threats to life. It is not surprising that therapeutic efforts now tend to focus upon those microbial species that remain poorly controlled by chemotherapy. With the possible exception of the hemolytic staphylococcus, the coliform and related gram-negative bacteria have been the most troublesome because of their irregular susceptibility to the drugs now available.6, 7Among these bacilli,Pseudomonas...Bibliography1. Yow EM: Development of Proteus and Pseudomonas infections during antibiotic therapy. J. A. M. A. 149: 1184, 1952. CrossrefMedlineGoogle Scholar2. MartinSpittelWellmanGeraci WMJAWEJE: Bacteremia owing to Pseudomonas aeruginosa: review of 10 cases. Proc. Staff Mayo Clin. 29: 562, 1954. MedlineGoogle Scholar3. ErwinWaisbrenKruse CPBAR: Clinical and laboratory studies of infections due to Pseudomonas aeruginosa and Pseudomonas species. Amer. J. Med. Sci. 226: 525, 1953. CrossrefMedlineGoogle Scholar4. AsayKoch LDR: Pseudomonas infections in infants and children. New Engl. J. Med. 262: 1062, 1960. CrossrefMedlineGoogle Scholar5. ForknerFreiEdgcombUtz CEEJHJP: Pseudomonas septicemia. Amer. J. Med. 25: 877, 1958. CrossrefMedlineGoogle Scholar6. Waisbren BA: Bacteremia due to gram-negative bacilli other than the Salmonella. Arch. Intern. Med. 88: 467, 1951. CrossrefGoogle Scholar7. MunroeCockcroft DSWH: Septicemia due to gram-negative bacilli. Canad. Med. Ass. J. 72: 586, 1955. MedlineGoogle Scholar8. FinlandJonesBarnes MWFMW: Occurrence of serious bacterial infections since introduction of antibacterial agents. J. A. M. A. 170: 2188, 1959. CrossrefMedlineGoogle Scholar9. Rogers DE: The changing pattern of life-threatening microbial disease. New Engl. J. Med. 261: 677, 1959. CrossrefMedlineGoogle Scholar10. Charrin A: Maladie pyocyonique chez l'homme. C. R. Soc. Biol. 9: 496, 1890. Google Scholar11. RingenDrake LMCH: A study of the incidence of Pseudomonas aeruginosa from various natural sources. J. Bact. 64: 841, 1952. CrossrefMedlineGoogle Scholar12. CaroliPlatteborse JR: Septicemie porto-cave. Cirrhoses du foie et septicemie a colibacille. Sem. Hop. Paris 34: 472, 1958. MedlineGoogle Scholar13. SchafferOppenheimer AJEH: Pseudomonas pyocyanea infection of the gastrointestinal tract in infants and children. Southern Med. J. 41: 460, 1948. CrossrefMedlineGoogle Scholar14. PetersdorfHookCurtinGrossberg RGEWJASE: The antimicrobial sensitivity of gram-negative pathogens. Bull. Johns Hopkins Hosp. To be published. Google Scholar15. CurtinPetersdorfBennett JARGIL: Acquired arteriovenous fistula complicated by Pseudomonas aeruginosa endarteritis and endocarditis. Bull. Johns Hopkins Hosp. 101: 140, 1957. MedlineGoogle Scholar16. Fraenkel E: Weitere untersuchungen uber die menschenpathogenitat des bacillus Pyocyaneus. Z. Hyg. Infektionskr. 84: 369, 1917. CrossrefGoogle Scholar17. Wassermann M: Ueber eine epidemie-artig aufgetretene septische nabelinfection neugeborener; ein beweis fur die pathogenetische wirksamkeit des Bacillus pyocyaneus beim menschen. Virchow. Arch. Path. Anat. 165: 342, 1901. CrossrefGoogle Scholar18. Hand AM: Pseudomonas aeruginosa sepsis. Southern Med. J. 47: 1049, 1954. CrossrefMedlineGoogle Scholar19. Kerby GP: Pseudomonas aeruginosa bacteremia: summary of literature with report of case. Amer. J. Dis. Child. 74: 610, 1947. CrossrefMedlineGoogle Scholar20. KeeferHewitt CSWL: The therapeutic value of streptomycin: a study of 3,000 cases. J. W. Edwards, Ann Arbor, Mich., 1948, pp. 25-27. Google Scholar21. BrillLibman NEE: Pyocyaneus bacillemia. A critical review of the recorded cases with the report of a case secondary to a staphylococcaemia. Amer. J. Med. Sci. 118: 153, 1899. CrossrefGoogle Scholar22. EastmanKeene JRTV: Bacillus pyocyaneus septicaemia associated with blastomycetic growth in primary wound. Ann. Surg. 40: 613, 1904. CrossrefMedlineGoogle Scholar23. Nieh C: Systemic Infection with B. pyocyaneus: review of literature and report of 7 cases. Chinese Med. J. 50: 1751, 1936. Google Scholar24. DitkowskyGoldmanGoldin SAM: Pseudomonas meningitis in an infant successfully treated with neomycin. Pediatrics 9: 101, 1952. MedlineGoogle Scholar25. Shwachman H: Mucoviscidosis. Amer. J. Dis. Child. 88: 380, 1954. Google Scholar26. Stanley MM: Bacillus pyocyaneus infections. Amer. J. Med. 2: pp. 253, 347, 1947. CrossrefMedlineGoogle Scholar27. FlormanSchifrin ALN: Observations on a small outbreak of infantile diarrhea associated with Pseudomonas aeruginosa. J. Pediat. 36: 758, 1950. CrossrefMedlineGoogle Scholar28. Finkelstein H: Bacillus pyocyaneus and hamorrhagische diathese. Charite Annalen 21: 346, 1896. Google Scholar29. Koch ML: Bacteremia due to bacterial species of the genera Aerobacter, Escherichia, Paracolabactrum, Proteus and Pseudomonas. Antibiot. Med. 2: 113, 1956. Google Scholar30. PetersdorfBennett RGIL: Unpublished observations. Google Scholar31. HunterEnsign CAPR: An epidemic of diarrhea in a newborn nursery caused by Pseudomonas aeruginosa. Amer. J. Public Health 37: 1166, 1947. CrossrefGoogle Scholar32. McLeod JW: The hospital urine bottle and bedpan as reservoirs of infection by Pseudomonas pyocyanea. Lancet 1: 1017, 1958. Google Scholar33. LilleyBearup ABAJ: Generalized infection due to Pseudomonas aeruginosa (Bacillus pyocyaneus), with study of characteristics of local strains of organism. Med. J. Aust. 1: 362, 1928. CrossrefGoogle Scholar34. ChakravartiTyagi DNNN: Pyrexia simulating that of enteric fever caused by Ps. pyocyanea in children. Indian M. Gazette 72: 367, 1937. MedlineGoogle Scholar35. MarkleyGurmendiCharezBazan KGPMA: Fatal pseudomonas specticemias in burned patients. Ann. Surg. 145: 175, 1957. CrossrefMedlineGoogle Scholar36. SilverUtzFreiMcCullough RTJPENB: Fever, infection and host resistance in acute leukemia. Amer. J. Med. 24: 25, 1958. CrossrefMedlineGoogle Scholar37. Mackeen RA: Bacillus pyocyaneus in the blood stream in a case of agranulocytic angina. Canad. Med. Ass. J. 24: 424, 1941. Google Scholar38. Fleisher MS: Significance of diphtheroid microorganisms in blood cultures from human beings. Amer. J. Med. Sci. 224: 548, 1952. CrossrefMedlineGoogle Scholar39. KasselRottino RA: Significance of diphtheroids in malignant disease studied by germ-free technique. Arch. Intern. Med. 96: 804, 1955. CrossrefGoogle Scholar40. FeltyKeefer ARCS: Bacillus coli sepsis: clinical study of 28 cases of blood stream infection by colon bacillus. J. A. M. A. 82: 1430, 1924. CrossrefGoogle Scholar41. BarringtonWright FJHD: Bacteremia following operations on the urethra. J. Path. Bact. 33: 871, 1930. CrossrefGoogle Scholar42. AppletonWaisbren DMBA: The prophylactic use of chloramphenicol in urethral resections of the prostate gland. J. Urol. 75: 304, 1956. CrossrefMedlineGoogle Scholar43. Grey DN: The incidence and type of bacteremia at the time of various prostatectomy procedures. J. Urol. 73: 709, 1955. CrossrefMedlineGoogle Scholar44. StoppelmanShwachman MRH: Effect of antibiotic therapy on mucoviscidosis. New Engl. J. Med. 251: 759, 1954. CrossrefMedlineGoogle Scholar45. Anderson DH: Long-term and prophylactic use of antibiotics. Panel discussion, H. F. Dowling, moderator, in Antibiotics Annual, 1955-1956. Edited by H. Welch and F. Marti-Ibanez. Medical Enclyclopedia, New York, 1956. Google Scholar46. GarrardRichmondHirsch SDJBMM: Pseudomonas aeruginosa infection as a complication of therapy in pancreatic fibrosis (mucoviscidosis). Pediatrics 8: 482, 1951. MedlineGoogle Scholar47. Kass EH: Chemotherapeutic and antibiotic drugs in management of infections of urinary tract. Amer. J. Med. 18: 764, 1955. CrossrefMedlineGoogle Scholar48. PetersdorfCurtinHoeprichPeelerBennett RGJAPDRNIL: A study of antibiotic prophylaxis in unconscious patients. New Engl. J. Med. 257: 1001, 1957. CrossrefMedlineGoogle Scholar49. Howe CW: Postoperative wound infections due to Staphylococcus aureus. New Engl. J. Med. 251: 411, 1954. CrossrefMedlineGoogle Scholar50. Weinstein L: Chemoprophylaxis of infection. Ann. Intern. Med. 43: 287, 1955. LinkGoogle Scholar51. Idem: Failure of chemotherapy to prevent bacterial complications of measles. New Engl. J. Med. 253: 679, 1955. CrossrefMedlineGoogle Scholar52. Jawetz E: Infections with Pseudomonas aeruginosa treated with polymyxin B. Arch. Intern. Med. 89: 90, 1952. CrossrefGoogle Scholar53. PetersdorfHook RGEW: The use of colistin in infections of the urinary tract. Bull. Johns Hopkins Hosp. 107: 133, 1960. MedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: *Received for publication October 31, 1960.Presented at the Forty-first Annual Session of The American College of Physicians, San Francisco, Calif., April 4, 1960.From the Departments of Medicine and Pathology, John Hopkins University School of Medicine, Baltimore, Md.†Dr. Curtin was formerly Commonwealth Fund Research Fellow in Medicine, Johns Hopkins University School of Medicine, Baltimore, Md.Requests for reprints should be addressed to James A. Curtin, M.D., Assistant Professor of Medicine and Microbiology, Georgetown University School of Medicine, Washington, D. C. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byViability of Antifungal Metabolite Producing Pseudomonas BacteriaColistin Is Effective in Treatment of Infections Caused by Multidrug-Resistant Pseudomonas aeruginosa in Cancer PatientsEffectiveness of Combination Antimicrobial Therapy for Pseudomonas aeruginosa BacteremiaPseudomonas aeruginosa infections in a neonatal intensive care unitSerious Infections Caused by Pseudomonas AeruginosaColonization of intensive care unit patients by Pseudomonas aeruginosaLocal and Disseminated Diseases Caused by Pseudomonas aeruginosaImmunochemical Prophylaxis against Pseudomonas aeruginosaHospital infection: the first 2500 yearsOropharyngeal and fecal carriage of Pseudomonas aeruginosa in hospital patientsO-Serotypes of Pseudomonas aeruginosa from animal and inanimate sources in Saudi ArabiaPyocyanin preparation fromPseudomonas aeruginosa isolated from heterogeneous clinical materialsC-reactive protein for detection and follow-up of bacterial and fungal infections in severely neutropenic patients with acute leukaemiaBacteraemia at the University Hospital of the West Indies - a report of 222 casesNew Selective Media for Enumeration and Recovery of Fluorescent Pseudomonads from Various HabitatsPseudomonas septicaemia. A review of 60 cases observed in a university hospitalPrevalence and antimicrobial sensitivity of localPseudomonas aeruginosa at a teaching hospitalGangrene of the Genitalia in Children with Pseudomonas SepsisPrimary pseudomonos septicaemia with complete recoveryNOMA NEONATORUM: ITS ÆTIOPATHOGENESISAnal stricture following pseudomonas sepsisPirbenicillin: Comparison with Carbenicillin and BL-P1654, Alone and with Gentamicin, Against Pseudomonas aeruginosaThe problem of infections in acute leukemiasMetastatic infection secondary to genitourinary tract sepsisPseudomonas bacteremiaIncreased Antibiotic Sensitivity in Pseudomonas aeruginosa Following Passage in Carbenicillin-containing MediaObservations on a post-operative septicaemia in experimental dogs with particular reference to Pseudomonas aeruginosaElastase of Pseudomonas aeruginosa : Inactivation of Complement Components and Complement-Derived Chemotactic and Phagocytic FactorsDissociation Between Results of In Vitro and In Vivo Antibiotic Susceptibility Tests for Some Strains of Pseudomonas aeruginosaAeruginocine typing of Pseudomonas aeruginosaPseudomonas aeruginosa Resistant to Carbenicillin and Gentamicin Epidemiologic and Clinical Aspects in a Cancer CenterWILLIAM H. GREENE, M.D., MARCIA MOODY, M.S., STEPHEN SCHIMPFF, M.D., VIOLA M. YOUNG, Ph.D., PETER H. WIERNIK, M.D.PSEUDOMONAS ON THE CHRYSANTHEMUMSAdvances in the management of Pseudomonas aeruginosa infections in cancer patientsPseudomonas septicemia: Incidence, epidemiology, prevention and therapy in patients with advanced cancerPSEUDOMONAS AERUGINOSA INFECTIONS IN RATS FED ON MONOSODIUM GLUTAMATE WITH OBSERVATIONS ON THE PSEUDOMONAS FLORA IN THEIR INTESTINESPseudomonas aeruginosa bacteremia in patients with neoplastic diseaseComparison of Tobramycin, Gentamicin, Colistin, and Carbenicillin in Pseudomonas Sepsis in MonkeysNormal Granulocyte Transfusion TherapyEffect of Vincristine Sulfate on Pseudomonas Infections in MonkeysMode of Transmission of Pseudomonas aeruginosa in a Burn Unit and an Intensive Care Unit in a General HospitalPseudomonas Aeruginosa InfectionsEmpiric Therapy with Carbenicillin and Gentamicin for Febrile Patients with Cancer and GranulocytopeniaKlinik und antibiotische Therapie der bakteriellen septischen Erkrankungen in der inneren MedizinInhibition and Destruction of Pseudomonas aeruginosaFine-Particle HumidifiersReferencesThe Clinical Significance of Necrosis of the SkinDie infarktoide PneumonieStaphylococcal Bacteremia and Altered Host ResistanceLEIGHTON E. CLUFF, M.D., F.A.C.P., RICHARD C. REYNOLDS, M.D., F.A.C.P., DAVID L. PAGE, M.D., JOHN L. BRECKENRIDGE, M.D.OBG: Contaminated Resuscitators: Fatal Threat to NewbornsCase 26-1968Endogenous Pseudomonas PanophthalmitisACUTE BACTERIAL INFECTIONS IN THE ELDERLY MALE: CULTURES AND ANTIBIOTIC SENSITIVITY TESTSPseudomonas Infections in Mink with Special Reference to Pseudomonas Vasculitis in Pulmonary LesionsCharacteristics of Nonbacteremic Pseudomonas PneumoniaJAMES R. TILLOTSON, M.D., A. MARTIN LERNER, M.D., F.A.C.P.Klinik und Pathologie der Aerobacter aerogenes-InfektionAn essay regarding pathogenesis and treatment of shock due to bacteremia with special reference to “gram-negative” shockTHE ROLE OF ANTIBIOTICS, VASOACTIVE DRUGS AND STEROIDS IN GRAM-NEGATIVE BACTEREMIAEtiology of BacteremiaPseudomonas aeruginosa Epidemic Traced to Delivery-Room ResuscitatorsSYSTEMIC PSEUDOMONAS INFECTION IN CHILDHOODZum Problem der mikrobiell bedingten Komplikationen bei Krankheitszuständen mit ausgeprägter Granulocytopenie1 Polypeptide Antibiotics of Medicinal InterestBacteremia Due to Gram-Negative RodsGram-negative Septicemia in UrologyGram-negative shock and endotoxin shockHYPOGAMMAGLOBULINÆMIA PRESENTING AS PSEUDOMONAS SEPTICÆMIATherapy of Acute Bacterial GastroenteritisUnusual Fatal Infectious Complications of Steroid-Treated Liver DiseasePyocyaneussepsis im Neugeborenenalter bei drei GeschwisternPseudomonas pyocyanea INFECTION TREATED WITH COLISTIN METHANE SULPHONATEUse of antibiotics in cancer and leukemiaFundamental and Therapeutic Concepts in Hypovolemic and Bacteremic ShockInfectious Disease EmergenciesAFTERMATH OF STERILISATIONCOLISTINFatal Pseudomonas Infection in Burned PatientsGreen for Danger 1 June 1961Volume 54, Issue 6Page: 1077-1107KeywordsBacteremiaDrugsInfantsNosocomial infectionsPathogensPseudomonasPseudomonas infectionsResearch fundingSepsisStaphylococcus ePublished: 1 December 2008 Issue Published: 1 June 1961 Copyright & PermissionsCopyright ©, 1961, by The American College of PhysiciansPDF downloadLoading ...