tbuckley/cabot-search huggingface dataset:
Intravenous Infusion Filters
Authors: George C. Brdlik
Journal: JAMA (1981)

To the Editor.—  I would like to add to the discussion between Graybeal and Schmidt (1980;244:332) on intravenous infusion filters. The important issue of the additional cost of routine filtration has been recently addressed by the National Coordinating Committee on Large Volume Parenterals (NCCLVP). In recommendations approved on Nov 30, 1979, 1 the NCCLVP has paid special attention to identifying the most appropriate clinical applications of filters, including the most suitable type of filter for a given situation. Rather than try to abstract these recommendations here, I urge clinicians involved in parenteral fluid therapy to refer to the original document for additional guidance.  Another problem not discussed by Graybeal and Schmidt is that of incompatibility of filters with many of the infusion pumps currently on the market. The pressure that some pumps can generate can damage some filters and integral filter administration sets, creating potentially unsafe conditions for the patient. 2
The New and the Old -- Molecular Diagnostics and Hemolytic Disease of the Newborn
Authors: Naomi L.C. Luban
Journal: New England Journal of Medicine (1993)

Hemolytic disease of the newborn occurs as a result of sensitization of the mother's immune system to red-cell antigens of the fetus. This sensitization results from the transplacental passage of fetal red cells possessing an antigen that is not present on maternal red cells. The IgG antibodies produced by the mother in response to the foreign antigen cross the placenta into the fetal circulation, bind to the red cells there, and destroy them. As a consequence of the hemolytic process, there is both extramedullary hematopoiesis and reticuloendothelial clearance of sensitized fetal cells, leading to hepatic and splenic enlargement. As the . . .
Alopecia and Amphetamine Use
Authors: David A. Voron
Journal: JAMA (1988)

<h3>To the Editor.—</h3> In Dr Fiedler's<sup>1</sup>response to the question entitled "Alopecia: A Relationship to Amphetamine Use?" in the QUESTIONS AND ANSWERS section of the March 25 issue of<i>JAMA</i>, she states that the "use of dextroamphetamine is not associated specifically with alopecia." However, in fact, diffuse loss of scalp hair has been reported in association with amphetamine use.<sup>2,3</sup>
Are GPs who specialise in dermatology effective?: Result for teamwork and planning is positive
Authors: Stephen F Hayes
Journal: BMJ (2006)

The nursing profession's coming of age The end of medicine as a professionEditor-Young describes the coming of age of the nursing profession. 1 All professions and occupations are human creations and therefore are subject to change.With the widening of roles of many professions, it becomes harder to define what a doctor can do that can't be done by an appropriately trained member of another profession.Perhaps major surgery and certifying cause of death are all that remains.With the increasing difficulty of getting junior doctors to do anything that may be regarded as work (rather than education) we doctors may be engineering the abolition of our profession, and we may move from distinct professions to practitioners from varied backgrounds being trained for a particular function.
PERISINUSAL ABSCESS OF THE LATERAL SINUSWITH METASTASIS IN LIVER AND STERNO-CLAVICULAR JOINT.
Authors: GORDON KING
Journal: JAMA (1904)

Aug. 1, 1901, there came for treatment in the Eye, Ear, Nose and Throat Hospital E. A., a white boy, 14 years of age, suffering with a chronic suppuration of the left ear which began in early childhood. The boy was of healthy parentage, and had been subject to very little illness during his life. Six years previously he was operated on at the hospital for postnasal adenoids, but did not continue attendance at the clinic for the treatment of his ear, which had been carelessly neglected by his parents. In the latter part of July, a week before returning to the clinic, he had begun to complain of pain in the left side of his head about the ear and in the left temple, accompanied by fever and occasional irregular chills. He was dull and listless, and appeared to be in a state of febrile depression. His mental condition
The First Five Minutes
Authors: Robert H. Moser
Journal: JAMA (1975)

Something is slipping away. Something vital, close to the core, is being eroded. Communication with patients—the heart of medicine, the essence of our art—is in peril from several aspects. In the past I have spoken of my fear of computers and my uneasiness about the integration of paramedical personnel into the practice of medicine. Let us ruminate each in turn. I acknowledge the virtue of the computer as a gatherer and caretaker of lifelong medical records. At first glance, how can one deprecate such a marvelous capability: to have the entire medical history of a patient from birth until this moment—as near as a computer terminal in your office! But I am worried. If<i>I</i>can punch the proper buttons and receive the information from the monster's bowels—who else can do it? What is to prevent anyone with access to the same buttons from also getting this extraordinarily personal information?
Application of polyglycolic acid sheets for delayed perforation after endoscopic submucosal dissection of early gastric cancer
Authors: Hiroyuki Ono, Kohei Takizawa, Naomi Kakushima, Masaki Tanaka, Noboru Kawata
Journal: Endoscopy (2015)

Since being developed and established in Japan, endoscopic submucosal dissection (ESD) has been widely used as a standard treatment for early gastric cancer [1]. Delayed perforation is an occasional complication of ESD, and despite its low incidence, it is a serious complication frequently requiring emergency operation [2] [3] [4]. Polyglycolic acid (PGA) sheets (Neoveil; Gunze Co., Japan), composed of bioabsorbable material, can be used to strengthen the ulcer floor after ESD [5]. We report the successful use of PGA sheets as a conservative treatment for delayed perforation.
Stanol/Sterol Ester–Containing Foods and Blood Cholesterol Levels
Authors: Alice H. Lichtenstein, Richard J. Deckelbaum
Journal: Circulation (2001)

Considerable attention in the recent past has focused on the potential benefits or adverse effects of butter versus different types of margarines, usually with respect to their relative content of polyunsaturated, saturated, and trans fatty acids, and the impact of these on low-density lipoprotein (LDL) cholesterol levels. Recently, a new class of margarines and other fat-derived products (eg, salad dressings, mayonnaise) containing plant-derived sterols that are intended for use to lower blood cholesterol levels have been introduced into the food supply. These products are being marketed as adjuncts to low-saturated-fat and low-cholesterol diets to maximize reductions in LDL cholesterol levels achievable by dietary means.
The Biopsychosocial Approach. Liaison Medicine and Its Models
Authors: Chase Patterson Kimball
Journal: Psychotherapy and Psychosomatics (1983)

Liaison psychiatry is an outgrowth of consultation psychiatry which it extends by emphasizing its teaching function with the physicians, nurses, and patients it has contact. Liaison teaches methods of identification, assessment, diagnosis, and therapy based primarily on an open-ended interview technique. This form serves in and of itself, as well as by extension, as a brief psychotherapeutic process. The liaison model utilizes a general systems approach in its study of the patient pursuing the latter's problem from the molecular through organ systems, intrapsychic processes and interactions with the social milieu. The biopsychosocial approach to the patient is one of addressing the patient and the significant others in the sequential stages of illness; acute, convalescent, and rehabilitative. These are largely influenced by the environments and the processes occurring therein. Liaison psychiatry might well be called ecumenical psychiatry inasmuch as it utilizes conceptual approaches derivative of the social sciences, psychoanalysis, behavioral medicine, neuroscience, and psychopharmacology. In addition, the function of the liaison consultant seems to be increasing as one in which he/she functions as an arbiter when there are conflicts between colleagues around decision-making processes. These frequently involve ethical problems affecting the behavior of staff and patients. The processes engaged in by the liaison psychiatrist will be elaborated.
Capsule endoscopy in refractory celiac disease
Authors: S. Daum, U. Wahnschaffe, R. Glasenapp, M. Borchert, R. Ullrich, M. Zeitz, S. Faiss
Journal: Endoscopy (2007)

Patients with refractory celiac disease (RCD) are at risk of intestinal T-cell lymphoma, which is difficult to diagnose because it often develops in the small bowel. We therefore studied whether wireless capsule endoscopy was able to detect ulcerative jejunitis or intestinal T-cell lymphomas that were missed by standard endoscopic and imaging procedures in patients with RCD.Detection of ulcerative jejunitis and overt T-cell lymphoma by capsule endoscopy or by upper and lower endoscopy, abdominal computed tomography (CT) or abdominal magnetic resonance tomography (MRT) was compared in 14 consecutive patients with RCD: in seven patients who showed loss of T-cell antigens on intraepithelial lymphocytes and/or clonality of the T-cell receptor gene (i. e. type II RCD) and in seven patients who did not have these features (i. e. type I RCD).Complete evaluation of the small bowel by capsule endoscopy was achieved in 9/14 patients. Signs of ulcerative jejunitis or intestinal T-cell lymphoma, affecting further clinical management, were found in two patients with type II RCD: in one patient these signs were found only by capsule endoscopy (ulcerations and stenosis) and in another patient the abnormalities were identified by CT/MRT (mesenteric lymph nodes harboring lymphoma). No clinically relevant abnormalities were found in patients with type I RCD by lower endoscopy or by small-bowel imaging (capsule endoscopy, CT, or MRT).In patients with type II RCD, capsule endoscopy can detect additional cases with ulcerative jejunitis and could be included in the diagnostic armamentarium, subject to confirmation by larger series. In patients with type I RCD, our study confirmed the low diagnostic yield of imaging procedures, including wireless capsule endoscopy.
Myocardial Infarction and Apoptosis After Myocardial Ischemia and Reperfusion
Authors: Antti P. Vakeva, Azin Agah, Scott A. Rollins, Louis A. Matis, Lan Li, Gregory L. Stahl
Journal: Circulation (1998)

Myocardial ischemia and reperfusion (MI/R)-induced tissue injury involves necrosis and apoptosis. However, the precise contribution of apoptosis to cell death, as well as the mechanism of apoptosis induction, has not been delineated. In this study, we sought to define the contribution of the activated terminal complement components to apoptosis and necrosis in a rat model of MI/R injury.Monoclonal antibodies (mAbs; 18A and 16C) raised against the rat C5 complement component bound to purified rat C5 (ELISA). 18A effectively blocked C5b-9-mediated cell lysis and C5a-induced chemotaxis of rat polymorphonuclear leukocytes (PMNs), whereas 16C had no complement inhibitor activity. A single dose (20 mg/kg i.v.) of 18A blocked >80% of serum hemolytic activity for >4 hours. Administration of 18A before myocardial ischemia (30 minutes) and reperfusion (4 hours) significantly reduced (91%) left ventricular free wall PMN infiltration compared with 16C treatment. Treatment with 18A 1 hour before ischemia or 5 minutes before reperfusion significantly reduced infarct size compared with 16C treatment. A significant reduction in infarct size (42%) was also observed in 18A-treated rats after 30 minutes of ischemia and 7 days of reperfusion. DNA ladders and DNA labeling (eg, TUNEL assay) demonstrated a dramatic reduction in MI/R-induced apoptosis in 18A-treated compared with 16C-treated rats.Anti-C5 therapy in the setting of MI/R significantly inhibits cell apoptosis, necrosis, and PMN infiltration in the rat despite C3 deposition. We conclude that the terminal complement components C5a and C5b-9 are key mediators of tissue injury in MI/R.
Clinical Measurement of Taste and Smell
Authors: Stanley M. Garn
Journal: JAMA (1987)

Taste and smell are two rather neglected senses, not for lack of interest but because they are so difficult to measure reliably. So audiometers and Snellen charts are standard equipment in the physician's office, but not devices to measure olfactory acuity or the tasting modes. This 602-page book, a conference volume, contains 33 studies contributed by specialists in taste and smell, nearly all of them from university departments and government laboratories—where the basic research is conducted. It starts with a series of studies on general problems of measuring, then goes on to the methodological problems inherent even in odor recognition. There are a short section on the nutritional complications of differences in taste and smell, a section on life-cycle development, and then two separate clinically oriented sections, the latter constituting some 200 pages in all. Although they were written by sensory specialists for sensory specialists, the arrangement of the six
INCIDENCE OF CONDUCTION DISTURBANCES AND NEED FOR PERMANENT PACEMAKER AFTER TRANSCATHETER IMPLANTATION OF AN EDWARDS SAPIEN AORTIC VALVE PROSTHESIS
Authors: Ana Laynez Carnicero, Itsik Ben-Dor, Camille Hauville, Gabriel Maluenda, Israel Barbash, Hironori Kitabata, Danny Dvir, salem badr, Rebecca Torguson, Zhenyi Xue, William Suddath, Lowell Satler, Augusto Pichard, Ron Waksman
Journal: Journal of the American College of Cardiology (2012)
‘Erratum to “Micro-patterned cell-sheets fabricated with stamping-force-controlled micro-contact printing” [Biomaterials 35 (2014) 9802–10]’
Authors: Nobuyuki Tanaka, Hiroki Ota, Kazuhiro Fukumori, Jun Miyake, Masayuki Yamato, Teruo Okano
Journal: Biomaterials (2014)
THE CHANGE OF NEOINTIMAL COVERAGE ON DRUG-ELUTING STENT STRUTS CROSSING SIDE-BRANCH VESSELS USING SERIAL OPTICAL COHERENCE TOMOGRAPHY
Authors: Seung-Yul Lee, Dong-Ho Shin, Jung-Sun Kim, Byeong-Keuk Kim, Young-Guk Ko, Donghoon Choi, Myeong-Ki Hong, Yang Soo Jang
Journal: Journal of the American College of Cardiology (2012)
Abstract 749: Predicting and improving potential anticancer proteomimetics with computational modeling
Authors: Kevin Chen
Journal: Cancer Research (2010)

Abstract In this work, computational approaches were used to investigate peptides for possible anticancer drug applications. Programmed cell death (apoptosis) is an important cellular process. Its malfunction can lead to cancer and other diseases. Apoptosis is regulated by both pro-death and pro-survival proteins. An over expression of pro-survival proteins can trigger cancer progression and poor chemotherapy response. A class of recently designed proteo-mimetics may help trigger death in cancer cells by hindering expression of certain pro-survival proteins. The Deep View program and the Swiss Model server were used to model interactions between pro-survival Bcl-xl protein and pro-death Bim protein. First, all binding residues of the Bcl-xl-Bim complex were identified. Bim residues were then systematically mutated. The goal was to study the significance of side chain groups for the complex formation. The changes in binding free energy, caused by the mutations, were calculated. Most mutations had a negligible influence on Bcl-xl-Bim interactions. However, some mutations produced additional bonds with Bcl-xl. Several residue substitutions led to minimization of free energies. Most of these residues were binding either at the original Bcl-xl binding or in its vicinity. The obtained minimum-energy peptides suggested putative proteomimetics that could form strong bonds with Bcl-xl. These could cause Bim to dislodge from the Bcl-xl binding site and thus stimulate apoptosis. The potential of the mutated peptides to hinder tumor cells’ survival is discussed. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 101st Annual Meeting of the American Association for Cancer Research; 2010 Apr 17-21; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2010;70(8 Suppl):Abstract nr 749.
Annular leucocytoclastic vasculitis induced by chlorzoxazone
Authors: C-S. Chiu, Y-C. Chang, W-H. Chung, L-J. Yang, H-C. Ho, M-J. Chen, H-S. Hong
Journal: British Journal of Dermatology (2004)

Journal Article Annular leucocytoclastic vasculitis induced by chlorzoxazone Get access C‐S. Chiu, C‐S. Chiu Department of Dermatology, Chang Gung Memorial Hospital, 199 Tung Hwa North Road, Taipei 100, Taiwan Search for other works by this author on: Oxford Academic Google Scholar Y‐C. Chang, Y‐C. Chang Department of Dermatology, Chang Gung Memorial Hospital, 199 Tung Hwa North Road, Taipei 100, Taiwan Search for other works by this author on: Oxford Academic Google Scholar W‐H. Chung, W‐H. Chung Department of Dermatology, Chang Gung Memorial Hospital, 199 Tung Hwa North Road, Taipei 100, Taiwan Search for other works by this author on: Oxford Academic Google Scholar L‐J. Yang, L‐J. Yang Department of Dermatology, Chang Gung Memorial Hospital, 199 Tung Hwa North Road, Taipei 100, Taiwan Search for other works by this author on: Oxford Academic Google Scholar H‐C. Ho, H‐C. Ho Department of Dermatology, Chang Gung Memorial Hospital, 199 Tung Hwa North Road, Taipei 100, Taiwan Search for other works by this author on: Oxford Academic Google Scholar M‐J. Chen, M‐J. Chen Department of Dermatology, Chang Gung Memorial Hospital, 199 Tung Hwa North Road, Taipei 100, Taiwan Search for other works by this author on: Oxford Academic Google Scholar H‐S. Hong H‐S. Hong Department of Dermatology, Chang Gung Memorial Hospital, 199 Tung Hwa North Road, Taipei 100, Taiwan Hong‐Shang Hong. E‐mail: chengsheng_chiu@hotmail.com Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 150, Issue 1, 1 January 2004, Page 153, https://doi.org/10.1111/j.1365-2133.2004.05681.x Published: 01 January 2004 Article history Accepted: 12 July 2003 Published: 01 January 2004
Crocidolite activates NF-kappa B and MIP-2 gene expression in rat alveolar epithelial cells. Role of mitochondrial-derived oxidants.
Authors: K E Driscoll, J M Carter, B W Howard, D Hassenbein, Y M Janssen, B T Mossman
Journal: Environmental Health Perspectives (1998)

Nuclear factor kappa B (NF-kappa B) is a transcription factor that regulates expression of several genes coding for inflammatory and immunoregulatory proteins including the neutrophil chemotactic cytokine MIP-2. In previous studies we found that crocidolite asbestos activates the nuclear translocation of NF-kappa B as well as MIP-2 gene expression in rat alveolar type II cells. Here we report that both crocidolite-induced NF-kappa B activation of MIP-2 gene expression can be attenuated by the antioxidant tetramethylthiourea, suggesting the dependence of these responses on oxidative stress. Crocidolite exposure of RLE-TN cells also increased production of H2O2, a response that was inhibited by the mitochondrial respiratory chain inhibitor thenoyltrifluoroacetone (TTFA). TTFA treatment of RLE-6TN cells also inhibited crocidolite-induced nuclear translocation of NF-kappa B and MIP-2 gene expression. These results indicate crocidolite exposure of rat alveolar type II cells results in increased production of mitochondrial-derived hydrogen peroxide and that mitochondrial-derived oxidants contribute to crocidolite activation of NF-kappa B and increases in MIP-2 gene expression.
Inflammatory Burden of Cardiac Allograft Coronary Atherosclerotic Plaque Is Associated With Early Recurrent Cellular Rejection and Predicts a Higher Risk of Vasculopathy Progression
Authors: Eugenia Raichlin, Jang-Ho Bae, Sudhir S. Kushwaha, Ryan J. Lennon, Abhiram Prasad, Charanjit S. Rihal, Amir Lerman
Journal: Journal of the American College of Cardiology (2009)
Delayed-Onset Heparin-Induced Thrombocytopenia
Authors: John R. De Palma
Journal: Annals of Internal Medicine (2003)

Letters4 November 2003Delayed-Onset Heparin-Induced ThrombocytopeniaJohn R. De Palma, MDJohn R. De Palma, MDFrom De Palma Medical Group, Inc.; Glendale, CA 91204.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-139-9-200311040-00017 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:There are 2 forms of heparin-induced thrombocytopenia. Type 1 is common and trivial. The incidence of heparin-induced thrombocytopenia type 2, which causes serious thrombosis in patients receiving full doses of heparin for therapy (not for hip replacement prophylaxis), is unknown (1). Heparin-induced thrombocytopenia type 2 is associated with platelet factor 4 antibodies and delayed thrombosis. Rice and colleagues (2) did not describe these 2 forms of heparin-induced thrombocytopenia. They indicated an incidence of approximately 3% for heparin but cited a reference for prophylactic heparin, not therapeutic heparin. I think they have muddied the waters. The Figure illustrates ...Reference1. Brieger DB, Mak KH, Kottke-Marchant K, Topol EJ. Heparin-induced thrombo-cytopenia. J Am Coll Cardiol. 1998;31:1449-59. [PMID: 9626819] CrossrefMedlineGoogle Scholar2. Rice L, Attisha WK, Drexler A, Francis JL. Delayed-onset heparin-induced throm-bocytopenia. Ann Intern Med. 2002;136:210-5. [PMID: 11827497] LinkGoogle Scholar Author, Article, and Disclosure InformationAuthors: John R. De Palma, MDAffiliations: From De Palma Medical Group, Inc.; Glendale, CA 91204. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoDelayed-Onset Heparin-Induced Thrombocytopenia Lawrence Rice , Walid K. Attisha , Alane Drexler , and John L. Francis Delayed-Onset Heparin-Induced Thrombocytopenia Robert Kane Delayed-Onset Heparin-Induced Thrombocytopenia Lawrence Rice , Walid K. Attisha , and John L. Francis Metrics 4 November 2003Volume 139, Issue 9Page: 790KeywordsAntibodiesHeparinHeparin-induced thrombocytopeniaHipMedical dialysisPlateletsProphylaxisRenal failureThrombosis ePublished: 4 November 2003 Issue Published: 4 November 2003 Copyright & PermissionsCopyright © 2003 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Transient Myopia Secondary to Adrenal Steroid-Induced Diabetes
Authors: Jack S. Nauheim
Journal: JAMA (1962)

THE OCCURRENCE of sudden refractive changes in diabetic patients and of diabetes in patients receiving steroids is well known. Examination of the<i>Current List of Medical Literature</i>from July, 1952, through April, 1961, and of the<i>Quarterly Cumulative Index Medicus</i>from June, 1949, through June, 1952, has revealed only 2 reports in which myopia occurred during corticotropin therapy. The case reported by Stern in 1955 showed no elevation of blood sugar 1½ hours after a light breakfast. Several of Larsen's cases showed slight to moderate increase in myopia or decrease in hyperopia during ACTH therapy. No tests for diabetes were reported. The following case illustrates how a change in refraction may be the first clue that a patient is suffering from steroid-induced diabetes. Report of a Case A 21-year-old male was diagnosed as having acute lymphogenous leukemia in June, 1960. He was treated with penicillin and streptomycin plus massive doses