<i>Helicobacter pylori</i>: Selection of Patients for Treatment
Authors: John H. Walsh
Journal: Annals of Internal Medicine (1992)

Editorials1 May 1992Helicobacter pylori: Selection of Patients for TreatmentJohn H. Walsh, MDJohn H. Walsh, MDSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-116-9-770 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptHelicobacter pylori (formerly called Campylobacter pylori) has been shown to infect the gastric mucus layer of almost all patients with duodenal ulcer disease, most patients with gastric ulcer disease, and almost all patients with histologic antral gastritis (1, 2). Its role in the pathogenesis of peptic ulcer disease and gastritis has been suggested by the findings that bacterial eradication markedly decreases duodenal ulcer recurrence rates (3, 4), reverses histologic gastritis (5), and may hasten healing of active duodenal ulcers (6). Antibacterial treatment and acid suppression are two effective approaches to the prevention of ulcer recurrence with different pathogenic mechanisms.The...References1. Peterson W. Helicobacter pylori and peptic ulcer disease. N Engl J Med. 1991;324:1043-8. CrossrefMedlineGoogle Scholar2. Graham D. Campylobacter pylori and peptic ulcer disease. Gastroenterology. 1989;96:615-25. CrossrefMedlineGoogle Scholar3. Marshall B, Goodwin C, Warren J, Murray R, Blincow E, and Blackbourn S. Prospective double-blind trial of duodenal ulcer relapse after eradication of Campylobacter pylori. Lancet. 1988;2:1437-41. CrossrefMedlineGoogle Scholar4. Rauws E and Tytgat G. Cure of duodenal ulcer associated with eradication of Helicobacter pylori. Lancet. 1990;335:1233-5. CrossrefMedlineGoogle Scholar5. Valle J, Seppälä K, Sipponen P, and Kosunen T. Disappearance of gastritis after eradication of Helicobacter pylori. A morphometric study. Scand J Gastroenterol. 1991;26:1057-65. 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A prospective comparison of symptoms and five diagnostic tests in patients with Helicobacter pylori positive and negative dyspepsia. European Journal of Gastroenterology and Hepatology. 1991;3: 463-8. Google Scholar16. Blaser M. Helicobacter pylori and the pathogenesis of gastroduodenal inflammation. J Infect Dis. 1990;161:626-33. CrossrefMedlineGoogle Scholar17. Egan J and Jensen D. Long-term management of patients with bleeding ulcers: rationale, results, and economic impact. Gastrointestinal Endoscopy Clinics of North America. 1991;1:367-85. CrossrefGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: John H. Walsh, MDAffiliations: University of California, Los Angeles Los Angeles, CA 90024 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byDual therapy versus triple therapy forHelicobacter pylori-associated duodenal ulcersUlcer recurrence among Filipino patients: Clinical profile and risk factorsRole ofHelicobacter pylori serology in evaluating treatment successThe need for long-term treatment of peptic ulcer 1 May 1992Volume 116, Issue 9 Page: 770-771 Keywords Duodenal ulcers Gastritis Helicobacter pylori Infectious diseases Mucus Pathogenesis Pathogens Patients Peptic ulcers Ulcers ePublished: 1 December 2008 Issue Published: 1 May 1992 PDF downloadLoading ...