tbuckley/cabot-search huggingface dataset:
Review: In type 1 or type 2 diabetes, group medical visits improve HbA<sub>1c</sub>levels compared with usual care
Authors: Marianne Sumego, David L. Bronson
Journal: Annals of Internal Medicine (2014)

ACP Journal Club18 February 2014Review: In type 1 or type 2 diabetes, group medical visits improve HbA1c levels compared with usual careMarianne Sumego, MD, David L. Bronson, MD, MACPMarianne Sumego, MDCleveland Clinic, Cleveland, Ohio. USA (M.S., D.L.B.)Search for more papers by this author, David L. Bronson, MD, MACPCleveland Clinic, Cleveland, Ohio. USA (M.S., D.L.B.)Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-160-4-201402180-02006 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail Source CitationHousden L, Wong ST, Dawes M. Effectiveness of group medical visits for improving diabetes care: a systematic review and meta-analysis. CMAJ. 2013;185:E635-44. https://pubmed.ncbi.nlm.nih.gov/23939218Clinical Impact RatingsGIM/FP/GP: Endocrinology: Reference1 Noffsinger EB. Group visits for efficient, high-quality chronic disease management. Group Practice Journal 2008;Feb:23-40. www.ma-ri-hfma.org/edudocs/June%2026,%202009%20Meeting%20Handouts/Noffsigner%20-%20Shared%20Medical%20Appointments%20-%202.pdf (accessed 11 Dec 2013). Google Scholar Author, Article, and Disclosure InformationAffiliations: Cleveland Clinic, Cleveland, Ohio. USA (M.S., D.L.B.)This article was published at Annals.org on 4 February 2014. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByCan Shared Service Delivery Increase Customer Engagement? A Study of Shared Medical AppointmentsIntegrative Medical Care Plus Mindfulness Training for Patients With Congestive Heart Failure 18 February 2014Volume 160, Issue 4Page: JC6KeywordsHbA1cHemoglobinMedical risk factorsObservational studiesPatientsQuality of lifeRisk managementSystematic reviewsType 2 diabetes ePublished: 18 February 2014 Issue Published: 18 February 2014 CopyrightCopyright © 2014 by American College of Physicians. All Rights Reserved.PDF DownloadLoading ...
Abstract 2986: Melanocytes are deficient in repair of oxidative DNA damage and UVC induced photoproducts
Authors: Hsiang-Tsui Wang
Journal: Cancer Research (2010)

Abstract Melanomas occur mainly in sunlight-exposed skin, xeroderma pigmentosum complementation (XP) patients, defective in nucleotide excision repair function, have 1000-fold higher incidence of melanoma. These findings indicate that sunlight induced “bulky” photoproducts are responsible for melanomagenesis. On the other hand, sunlight also induces a high level of reactive oxygen species (ROS) in melanoctes (MC), oxidative DNA damage (ODD) therefore may contribute to melanomagenesis and that the XP protein may participate in ODD repair. To address these questions we determined: 1) the effect of melanin on UVA (320-400 nm) irradiation induced ODD and UV photoproducts using formamidopyrimidine glycosylase (Fpg) and UvrABC incision assays, 2) the repair capacity for ODD and UV-induced photoproducts in MC and XPA cells using host cell reactivation and in vitro DNA repair synthesis assays. We found: 1) UVA irradiation-inducing a significantly higher amount of Fpg sensitive ODD in MC than in normal human skin fibroblasts (NHSF). In contrast, UVA irradiation induces an insignificant amount of UvrABC sensitive sites in either of these two types of cells. 2) Compared to NHSF, MC have a reduced repair capacity for ODD and photoproducts. 3) H2O2 modified DNA induces a higher mutation frequency in MC than in NHSF. 4) XPA cells are deficient in ODD repair and ODD induces a higher mutation frequency in XPA cells than in NHSF. Based on these results, we propose: 1) UVA is a major etiological agent for melanomagenesis and the mechanism is through melanin sensitizes UVA in induction of ODD and reduced repair capacity in MC; 2) the reduced repair capacity for ODD contributes to the high melanoma incidence in XPA patients. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 101st Annual Meeting of the American Association for Cancer Research; 2010 Apr 17-21; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2010;70(8 Suppl):Abstract nr 2986.
P501 CARDIOPULMONARY EXERCISE TESTING IN PATIENTS WITH PORTAL HYPERTENSION AND EARLY STAGE LIVER DISEASE
Authors: P. Douschan, G. Kovacs, V. Stadlbauer, W. Spindelboeck, E. Krones, F. Durchschein, G. Zollner, F. Rainer, V. Foris, P. Fickert, H. Olschewski, R. Stauber
Journal: Journal of Hepatology (2014)
Regarding Christian Science.
Authors: Archibald McLellan
Journal: JAMA (1901)

Chicago, Sept. 12, 1901. <h3>To the Editor:</h3> —InThe Journalof July 27 was published what was supposed to be "a sample of Christian Science," "a prayer for a dyspeptic, drawn up by Mr. Hazzard, president of the New York School of Primitive and Practical Christian Science." Please permit me to state through your columns that the gentleman mentioned is not a Christian Scientist, his school is not a Christian Science school, the prayer attributed to him is not a Christian Science prayer, and the publication to which it is credited is not a Christian Science publication. Any deductions, therefore, which might be drawn as to the teachings of Christian Science from the "prayer for a dyspeptic" must be erroneous.
Viral Hepatitis
Authors: Joan P. Giles, Robert W. McCollum, L. W. Berndtson, Saul Krugman
Journal: New England Journal of Medicine (1969)

Serial serum specimens (before infection through 200 days after infection) in 31 MS-1 (short incubation) and 19 MS-2 (long incubation) cases of viral hepatitis were examined for the presence of Australia/SH antigen. An agar-gel double-diffusion technic was used. The antigen was not detected in any serum from the MS-1 series, but it appeared regularly after MS-2 infection, usually well in advance of evidence of hepatitis. In approximately half the MS-2 infections the antigen was present only transiently (up to 68 days), but in the remainder, it persisted throughout the period of intensive observation and for at least three years subsequently.
Clinical use of ultrashort-lived radionuclide krypton-81m for noninvasive analysis of right ventricular performance in normal subjects and patients with right ventricular dysfunction
Authors: Christoph A. Nienaber, Rolf P. Spielmann, Gerd Wasmus, Detlef G. Mathey, Ricardo Montz, Walter H. Bleifeld
Journal: Journal of the American College of Cardiology (1985)
Corticotropin increases the receptor-specific uptake of native low-density lipoprotein (LDL)—but not of oxidized LDL and native or oxidized lipoprotein(a) [LP(a)]—in HEPG2 cells: No evidence for Lp(a) catabolism via the LDL-receptor
Authors: Werner Bartens, Annette Krämer-Guth, Christoph Wanner
Journal: Metabolism (1997)
Excessive daytime sleepiness in patients with sleep-disordered breathing
Authors: A. BaHammam
Journal: European Respiratory Journal (2008)

To the Editors: 

I read with interest the article by Mediano et al. 1 about excessive daytime sleepiness (EDS) in patients with obstructive sleep apnoea (OSA). In order to investigate the determinants of EDS in OSA patients, the authors compared the demographics and polysomnographic variables of two groups of OSA patients who had a similar apnoea/hypopnoea index (AHI), age and body mass index (BMI). Nocturnal hypoxaemia was reported to be a major determinant of EDS in patients with OSA.

I would like to point out that the possible coexistence of obesity hypoventilation syndrome (OHS), which is a known cause of EDS, was not ruled out in the …
How Strictly Do Dialysis Patients Want Their Advance Directives Followed?
Authors: Ashwini Sehgal
Journal: JAMA (1992)

<h3>Objective.</h3> —The<i>Cruzan</i>case and the Patient Self-Determination Act will encourage patients to specify in advance which life-sustaining treatments they would want if they become mentally incompetent. However, strictly following such advance directives may not always be in a patient's best interests. We sought to determine whether patients differ in how strictly they want advance directives followed. <h3>Design.</h3> —Interview study. <h3>Setting.</h3> —Seven outpatient chronic dialysis centers. <h3>Participants.</h3> —One hundred fifty mentally competent dialysis patients. <h3>Intervention.</h3> —Using a structured questionnaire, we asked the subjects whether they would want dialysis continued or stopped if they developed advanced Alzheimer's disease. We then asked how much leeway their physician and surrogate should have to override that advance directive if overriding were in their best interests. Subjects granting leeway were also asked what factors should be considered in making decisions for them. <h3>Results.</h3> —Subjects varied greatly in how much leeway they would give surrogates to override their advance directives: "no leeway" (39%), "a little leeway" (19%), "a lot of leeway" (11%), and "complete leeway" (31%). Subjects also varied in how much they wanted various factors considered in making decisions, such as pain or suffering, quality of life, possibility of a new treatment, indignity caused by continued treatment, financial impact of treatment on family members, and religious beliefs. <h3>Conclusions.</h3> —Strictly following all advance directives may not truly reflect patients' preferences. To improve advance directives, we recommend that physicians explicitly ask patients how strictly they want their advance directives followed and what factors they want considered in making decisions. (<i>JAMA</i>. 1992;267:59-63)
Durable response to etoposide‐loaded platelets in refractory immune thrombocytopenic purpura: A case report
Authors: Lucille Wood, Peter Jacobs
Journal: American Journal of Hematology (1988)

Abstract A 23‐year‐old female presented with widespread purpura and ecchymoses as a result of immune thrombocytopenia which was refractory to corticosteroids, splenectomy, and immunosuppressive agents. In view of the extent and serious nature of her bleeding, salvage therapy with etoposide‐loaded platelets was undertaken, which was associated with a lasting complete remission.
The Gamma Globulins
Authors: Chester A. Alper, Fred S. Rosen, Charles A. Janeway
Journal: New England Journal of Medicine (1966)

Benign M-Type HypergammaglobulinemiaWhen an M component is present in the serum of a person who has no or only minimal signs or symptoms235 the clinician is faced with the problem of deciding whether the patient will go on to develop classic multiple myeloma or macroglobulinemia, whether he has an occult malignant process with an associated M component or whether he has benign monoclonal hypergammaglobulinemia. Waldenstrorn236 has followed a large number of such patients for many years, as have others.237 , 238 In most cases it is only long-term follow-up study that provides the answer. The patients with true benign M-type hypergammaglobulinemia . . .
Role of endothelin, nitric oxide and L-arginine release in ischaemia/reperfusion injury of rat heart
Authors: F Brunner
Journal: Cardiovascular Research (1997)

Objectives: We tested the hypothesis that endothelin-1 (ET-1) aggravates ischaemia/reperfusion injury by stimulating cellular L-arginine depletion, which would result in reduced synthesis of nitric oxide (NO) and withdrawal of cardioprotection. Methods: Five groups of rat hearts (n = 5 each) were perfused at 9 ml/min per g for 45 min, subjected to 15 min total global ischaemia and reperfused for 30 min; they received, from 5 min pre-ischaemia to end of reperfusion, either vehicle, L-arginine (1 mmol/l), the NO donor S-nitroso-N-acetyl-DL-penicillamine (SNAP; 200 μmol/l), the inhibitor of NO formation NG-nitro-L-arginine (L-NNA; 200 μmol/l), or the ET receptor antagonist PD 142893 (200 nmol/l). Cardiac function and release of L-arginine, cyclic GMP and lactate dehydrogenase (LDH) into coronary effluent were measured. Results: Systolic, diastolic, and coronary reperfusion function were consistently improved by L-arginine, SNAP, or PD 142893, but worsened by L-NNA (P<0.05 in each case). L-arginine release was transiently increased up to 25-fold on reperfusion (vehicle); release was reduced by SNAP (mean: 68%) and entirely prevented by PD 142893. Despite the increased outflow of L-arginine, formation of cyclic GMP was not reduced, but enhanced in reperfusion (11-fold; vehicle), and SNAP further augmented this release, but L-NNA had no significant effect. Release of LDH was decreased by L-arginine, SNAP, and PD 142893 in reperfusion. Finally, release of ET-1 was inhibited by NO in normoxia as well as throughout reperfusion as evident from the stimulatory effect of L-NNA. Conclusion: In ischaemia, ET-1 causes cell necrosis and L-arginine outflow without compromising NO synthesis in this model.
Herpes increases because oral sex thought safe
Authors: Stephen Pincock
Journal: BMJ (2006)

Sexually active gay men are at increasing risk of contracting type 1 herpes simplex virus as a sexually transmitted disease, Australian researchers said this week.

As oral sex becomes more prevalent, sexual transmission of the infection—normally associated with cold sores around the mouth—is increasing, Andrew Grulich from the University of New South Wales and colleagues say in the Journal of Infectious Diseases (2006;194:561-70).

“We've demonstrated … the first prospective data to convincingly show that oral sex is a risk factor for HSV-1 [herpes simplex virus type 1] infection,” Dr Grulich says. “What we're …
Reply to G. Chantada et al and B.S. Wallang et al
Authors: Brenda L. Gallie, Helen S.L. Chan, Helen Dimaras, Junyang Zhao
Journal: Journal of Clinical Oncology (2011)

at presentation.Despite the authors' claim that extraocular retinoblastoma was excluded by imaging studies, the possibility of microscopic invasion remains.Even if primary enucleation had been done, the histopathologic risk stage would have remained at pT4b, necessitating aggressive adjuvant therapy.It might be agreed though, that had the patients undergone primary enucleation, time would have been gained in identifying the high risk factors earlier.Third, the shorter follow-up seen in the pre-enucleation chemotherapy group is implied by the authors to result from a lower risk perception leading to decreased surveillance.We feel however, that other unknown factors may have been responsible for the shorter follow-up in this group.The rationale behind chemoreduction is to downstage the tumor.Despite the deaths described in the article in the pre-enucleation chemotherapy group, a large majority (93%) of children did not develop metastasis.Of the four children who went on to die of metastasis, downstaging was noted only in one child while the rest showed a high pTNM stage after enucleation.
Anti-inflammatory gene therapy in the donor improves graft function after lung transplantation
Authors: A Fisher
Journal: Thorax (2005)

▴ Tagawa T, Dharmarajan S, Hayama M, et al . Endobronchial gene transfer of soluble type I interleukin-1 receptor ameliorates lung graft ischemia-reperfusion injury. Ann Thorac Surg2004;78:1932–9 [OpenUrl][1][PubMed][2] Ischaemia-reperfusion injury remains an important cause of primary graft failure and early mortality after lung transplantation. Interleukin (IL)-1, an early response and potent pro-inflammatory cytokine, has been implicated in the pathophysiology. In this paper the role of transfection of donor lungs with an adenoviral vector for soluble type … [1]: {openurl}?query=rft.jtitle%253DThe%2BAnnals%2Bof%2BThoracic%2BSurgery%26rft.stitle%253DAnn.%2BThorac.%2BSurg.%26rft.issn%253D0003-4975%26rft.aulast%253DTagawa%26rft.auinit1%253DT.%26rft.volume%253D78%26rft.issue%253D6%26rft.spage%253D1932%26rft.epage%253D1939%26rft.atitle%253DEndobronchial%2BGene%2BTransfer%2Bof%2BSoluble%2BType%2BI%2BInterleukin-1%2BReceptor%2BAmeliorates%2BLung%2BGraft%2BIschemia-Reperfusion%2BInjury%26rft_id%253Dinfo%253Apmid%252F15561003%26rft.genre%253Darticle%26rft_val_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Ajournal%26ctx_ver%253DZ39.88-2004%26url_ver%253DZ39.88-2004%26url_ctx_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Actx [2]: /lookup/external-ref?access_num=15561003&link_type=MED&atom=%2Fthoraxjnl%2F60%2F4%2F319.atom
Human ESC-derived hemogenic endothelial cells undergo distinct waves of endothelial to hematopoietic transition
Authors: Shahin Rafii, Christopher C. Kloss, Jason M. Butler, Michael Ginsberg, Eric Gars, Raphael Lis, Qiansheng Zhan, Pavle Josipovic, Bi-Sen Ding, Jenny Xiang, Olivier Elemento, Nikica Zaninovic, Zev Rosenwaks, Michel Sadelain, Jeremie A. Rafii, Daylon James
Journal: Blood (2012)
"TRAUMATIC ULCER OF THE DUODENUM AND STOMACH"
Authors: Gregory Connell
Journal: JAMA (1933)

To  Editor:  —InThe Journal, May 27, Drs. Crohn and Gerendasy report a case and discuss  subject of traumatic  of  duodenum and stomach. The conclusion that the evidence seems convincing that  trauma caused  ulcer might be misleading. The reference to students of gastro-enterology refusing to accept  concept of traumatic gastric ulcer calls for elucidation as to just what this concept is.  The four postulates of Liniger and Molineus satisfactorily exclude cases of pseudo-ulcer but fail to explain why gastro-duodenal trauma should be followed by  development of  in certain cases and not in others.  The evidence in  reported case is certainly convincing, that  trauma caused  injury to  duodenal mucous membrane. Of this sequence there can be no reasonable doubt.  Because  intestinal mucosa, like  skin, has an inherent tendency toward repair, something more than  injury is
<i>AMP</i> v. <i>Myriad</i> : A Surgical Strike on Blockbuster Business Models
Authors: Richard E. Gold, Robert Cook-Deegan, Tania Bubela
Journal: Science Translational Medicine (2013)

The U.S. Supreme Court’s decision in the Myriad Genetics case will promote translation of genetics-based diagnostics while preserving patent protection for other biomedical products.
Characteristics of Family Background in Bulimia
Authors: Laurence Igoin-Apfelbaum
Journal: Psychotherapy and Psychosomatics (1985)

21 women consulting for bulimia were followed in individual psychotherapy and assessed for family background characteristics. Two sets of data are reported: objective data concerning the incidence of 'broken homes', i.e., with a history of separation or divorce or death of parents; subjective data concerning the image of the family and the identifications which are worked through in psychotherapy. Among our 25 bulimic patients, 13 patients came from 'broken homes' in which, in 9 cases, separations were so radical that it was impossible to maintain relationships with both parents; 12 patients came from close-knit families which in 6 cases were actually 'closed families' hiding massive internal tensions. The proportion of broken homes is significantly higher than in a population of 25 overweight patients without bulimia also undergoing individual psychotherapy. There exists a sharp discrepancy between the actual family failings and the wish of patients to maintain their 'family unit' fantasy. The hypothesis is made that the occurrence of bulimia may be related to the combination of a history of violent separations (or threats of violent separation) in the family, and the endless denial of these separations.
Author in the Room
Authors: Catherine D. DeAngelis, Donald M. Berwick
Journal: JAMA (2005)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Extraglomerular origin of the mesangial cell after injury. A new role of the juxtaglomerular apparatus.
Authors: C Hugo, S J Shankland, D F Bowen-Pope, W G Couser, R J Johnson
Journal: Journal of Clinical Investigation (1997)

We investigated the origin of the glomerular mesangial cell, a smooth muscle-like cell that provides structural support in the glomerulus. Injection of anti-Thy 1 antibody that binds the Thy 1 antigen on rat mesangial cells eliminated (> 95%) the mesangial population at 20-28 h, while Thy 1-positive cells in the juxtaglomerular apparatus (JGA) were sequestered from the circulation and survived. Single pulse labeling with [3H]thymidine at 36 h labeled Thy 1-positive cells in the JGA and hilus. Serial biopsies demonstrated the progressive migration (5-15 micron/d) and proliferation of these mesangial reserve cells until the entire glomerulus was repopulated. The regenerating mesangial population expressed contractile and migratory proteins preferentially at the leading edge of the migratory front. Single as well as multiple pulse labeling with [3H]thymidine confirmed that the entire mesangial cell repopulation originated from only a few mesangial reserve cells. These reserve cells resided in the extraglomerular mesangium in the JGA and were not renin-secreting cells, macrophages, smooth muscle cells, or endothelial cells. These studies document mesangial cell migration in the anti-Thy 1 model of mesangial proliferative glomerulonephritis and provide evidence for a new role for the juxtaglomerular apparatus in the maintenance of the mesangial cell population.