The Nonefficacy of Short-term Anabolic Steroid Therapy in Alcoholic Liver Disease
Authors: L. FREDERICK FENSTER
Journal: Annals of Internal Medicine (1966)

Article1 October 1966The Nonefficacy of Short-term Anabolic Steroid Therapy in Alcoholic Liver DiseaseL. FREDERICK FENSTER, M.D.L. FREDERICK FENSTER, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-65-4-738 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptAnabolic steroids have been advocated as useful therapeutic agents in the management of patients with active cirrhosis. However, despite several glowing reports of a beneficial effect (1-3), controls generally have been lacking. An exception is the experience reported by Wells (4) in which patients with cirrhosis given testosterone propionate parenterally for 14 to 86 weeks were thought to fare better than a placebo-treated group and as well as a prednisolone-treated group. However, the study group consisted of patients with several types of cirrhosis, the duration of therapy varied from patient to patient, and only selected data were presented. More recently,...References1. ROSENAKMOSERKILGORE BDRHB: Treatment of cirrhosis of the liver with testosterone propionate. Gastroenterology 9: 695, 1947. MedlineGoogle Scholar2. KINSELL LW: Factors affecting protein balance in the presence of chronic viral liver damage. Gastroenterology 11: 672, 1948. MedlineGoogle Scholar3. GIROLAMI M: Treatment of ascitic atrophic cirrhosis of the liver with high dosages of testosterone propionate. Amer. Geriat. Soc. J. 6: 306, 1958. CrossrefMedlineGoogle Scholar4. WELLS R: Prednisolone and testosterone propionate in cirrhosis of the liver. A controlled trial. Lancet 2: 1416, 1960. CrossrefMedlineGoogle Scholar5. LEEVY CM: Fatty liver: a study of 270 patients with biopsy proven fatty liver and a review of the literature. Medicine (Balt.) 41: 249, 1962. CrossrefMedlineGoogle Scholar6. SQ 16, 374, Squibb Methenolone Enanthate, Summary of Information for Clinical Investigators. The Squibb Institute for Medical Research, New Brunswick, N. J., 1962. Google Scholar7. POSTPATEK JAJ: Serum proteins in cirrhosis of the liver. II. Nitrogen balance studies on 5 patients. Arch. Intern. Med. (Chicago) 69: 83, 1942. CrossrefGoogle Scholar8. GABUZDAECKHARDTDAVIDSON GJRDCS: Effect of choline and methionine, testosterone propionate, and dietary protein on nitrogen balance in patients with liver disease. J. Clin. Invest. 29: 566, 1950. CrossrefMedlineGoogle Scholar9. LLOYDWILLIAMS CWRH: Endocrine changes associated with Laennec's cirrhosis of the liver. Amer. J. Med. 4: 315, 1948. CrossrefMedlineGoogle Scholar10. MÜTING D: Protein metabolism, excretion, and detoxication functions of the liver after long-term treatment of liver cirrhosis with an anabolic substance. Amer. J. Dig. Dis. 10: 790, 1965. CrossrefMedlineGoogle Scholar11. GROSSMANYALOW JAA: Effects of anabolic steroids on albumin metabolism. J. Clin. Endocr. 25: 698, 1965. CrossrefGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Seattle, WashingtonFrom the Department of Medicine, King County Hospital and the University of Washington School of Medicine, Seattle, Wash.This study was supported in part by Squibb & Sons, E. R., New York, N. Y.Requests for reprints should be addressed to L. Frederick Fenster, M.D., King County Hospital, 325 Ninth Ave., Seattle, Wash. 98104. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByUpcoming Pharmacological and Interventional Therapies for the Treatment of Physical Frailty and SarcopeniaPharmacological interventions for alcoholic liver disease (alcohol-related liver disease)Androgen Therapy for Hypogonadism in Men with Chronic IllnessesSex Differences in Muscle WastingTestosterone in men with advanced liver disease: Abnormalities and implicationsHépatite alcoolique aiguëAnabolic-androgenic steroids for alcoholic liver diseaseTreatment of Alcoholic HepatitisAnabolic-androgenic steroids for alcoholic liver diseaseAnabolic-Androgenic Steroids for Alcoholic Liver Disease: A Cochrane ReviewALCOHOL-INDUCED LIVER DISEASEAndrogen therapy in non-gonadal diseaseEthanol and Lipid Disorders, Including Fatty Liver, Hyperlipemia, and AtherosclerosisAlcohol and the LiverAlcoholic Hepatitis: Pathogenesis and Approaches to TreatmentTreatment of alcoholic liver diseaseA randomized controlled study of peripheral parenteral nutrition in moderate and severe alcoholic hepatitisComplexity and contradiction in clinical trial researchTestosterone treatment of men with alcoholic cirrhosis: A double-blind studyIs therapy with testosterone or anabolic-androgenic steroids useful in the treatment of alcoholic liver disease?Natural History of Complications of Alcoholic Liver DiseaseShort-Term and Long-Term Survival in Patients with Alcoholic Hepatitis Treated with Oxandrolone and PrednisoloneAnabolic-androgenic steroid treatment of liver diseasesShort-Term Parenteral and Peroral Testosterone Administration in Men with Alcoholic CirrhosisAlcoholic hepatitisMetabolic Effects of Alcohol on the LiverMiscellaneous Uses of Anabolic SteroidsLIVER DISEASE AND ALCOHOL: FATTY LIVER, ALCOHOLIC HEPATITIS, CIRRHOSIS, AND THEIR INTERRELATIONSHIPSTherapy of Alcoholic Liver Disease**Supported in part by the Stratfield Fund.Augmented release of hepatic triglycerides with anabolic steroids in patients with fatty liverEffects of ethanol upon lipid metabolismLiver Disease in AlcoholismHepatic and Metabolic Effects of Alcohol (1966 to 1973)Treatment of Liver Disease with CorticosteroidsAlcoholic Hepatitis Natural History and Evaluation of Prednisolone TherapyRICHARD A. HELMAN, M.D., MICHAEL H. TEMKO, M.D., SYLVANUS W. NYE, M.D., HAROLD J. FALLON, M.D.Therapeutic Considerations in Selected Forms of Acute and Chronic Liver DiseaseEffects of Ethanol on Lipid, Uric Acid, Intermediary, and Drug Metabolism, Including the Pathogenesis of the Alcoholic Fatty LiverAlcoholic Fatty LiverAnabolic steroid therapy as an adjunct to diet in alcoholic hepatic steatosis 1 October 1966Volume 65, Issue 4Page: 738-744KeywordsAlcoholicsBiostatisticsCirrhosisHospital medicineLiver diseasesPatient advocacyPropionatesSteroid therapyTestosterone Issue Published: 1 October 1966 PDF DownloadLoading ...