tbuckley/cabot-search huggingface dataset:
Renal Artery Stenosis in Transplanted Kidney: Management and Results in Six Patients
Authors: N. Serrallach, R. Serrate, E. Franco, J. Muñoz, F. Aguilo, R. Gutierrez, G. Rius, X. Montaña, M. Marco-Luque, M.A. Cairols, J. Griño
Journal: European Urology (1985)
Autologous Stem Cell Transplantation (ASCT) in CLL. Results of a Phase III Randomized Multicenter Trial.
Authors: Laurent Sutton, Sylvie Chevret, Karim Maloum, Olivier Tournilhac, Marine Diviné, Veronique Leblond, Bernadette Corront, Stephane Lepretre, Houchingue Eghbali, Eric Van Den Neste, Mauricette Michallet, Frederic Maloisel, Krimo Bouabdallah, Christian Berthou, Pauline Brice, Didier Decaudin, Hugo Gonzalez, Florence Nguyen Khac, Frederic Davi, Julie Lejeune, Helene Merle-Beral, Michel Leporrier
Journal: Blood (2009)
Hypocomplementaemic urticarial vasculitis: successful treatment with cyclophosphamide-dexamethasone pulse therapy
Authors: None Worm, None Muche, None Schulze, None Sterry, None Kolde
Journal: British Journal of Dermatology (1998)

Systemic hypocomplementaemic urticarial vasculitis unresponsive to several immunosuppressive and immunomodulatory drugs was seen in two women aged 43 and 45 years. Cyclophosphamide-dexamethasone pulse therapy was started in both patients and resulted in significant clinical improvement. The pulse treatment was well tolerated in both patients and no major adverse effects occurred. These cases indicate that cyclophosphamide-dexamethasone pulse therapy is efficient in the treatment of hypocomplementaemic urticarial vasculitis.
Intergenerational transmission of child abuse: rates, research, and clinical implications
Authors: J E Oliver
Journal: American Journal of Psychiatry (1993)

The author reviews current wisdom concerning the rates and mechanisms of intrafamilial components of intergenerational transmission of child abuse and illustrates the unreliability of basic data and of assumptions made by reviewers and partisan advocates, most of whom underestimate the importance of intrafamilial factors in child abuse.The information in the report was derived from original research plus a recently prepared compilation of 60 studies, mainly from the United States and the United Kingdom.The crude rates of intergenerational transmission of child abuse according to the studies reviewed are as follows: one-third of child victims grow up to continue a pattern of seriously inept, neglectful, or abusive rearing as parents. One-third do not. The other one-third remain vulnerable to the effects of social stress on the likelihood of their becoming abusive parents. Intrafamilial factors appear to be the cause of personally directed, as opposed to culturally condoned, child abuse. Broad social factors, and some medical and psychiatric conditions, lower or raise thresholds in which family and personal vulnerabilities and propensities operate.There is no justification for any extremist advocacy in apportioning responsibility between the "sins of the parents" and the failings of society. The contention that clinical research on abuse is inferior to, and must give way to, large-scale or statistically balanced self-report and questionnaire surveys is plausible, popular, convincing, and wrong.
Severe mental illness in prisoners
Authors: T. Fryers, T. Brugha, A. Grounds, D. Melzer
Journal: BMJ (1998)

It will surprise few that mental health problems are common in people in prison, especially those on remand. 1 2 But in the light of the longstanding policy consensus that people with severe mental illness should be cared for in health and social services, the results of a recent national survey of mental disorders in prisons are still a shocking indication of inappropriate and inadequate psychiatric care on a huge scale.

The survey, funded by the Department of Health,3 was based on semistructured clinical interviews and is the latest in the important series of studies of psychiatric epidemiology in Great Britain carried out by the Office for National Statistics.4 Its most dramatic finding is the high rate of functional psychosis: 7% of sentenced men, 10% of men on remand, and 14% of women in both categories were assessed as having a psychotic illness within the past year. Although methodological differences render comparisons with previous studies of prisoners difficult, the key comparative figure is 0.4% for adults in the general population.4People with a dual diagnosis of mental illness and substance abuse pose a special problem, also a current concern in the United States. …
Variation in allergen content over time of acrylates/methacrylates in patch test preparations
Authors: A.T.J. Goon, M. Bruze, E. Zimerson, Ö. Sörensen, C.L. Goh, D.S.Q. Koh, M. Isaksson
Journal: British Journal of Dermatology (2010)

Background Acrylates/methacrylates are volatile substances. There might be a gradual decrease in acrylate/methacrylate allergen content over time in patch test preparations but this has not yet been documented. Objectives To determine the allergen content of acrylates/methacrylates in patch test preparations over time under different storage conditions. Methods Five acrylate/methacrylate allergens [2-hydroxyethyl methacrylate (2-HEMA), methyl methacrylate (MMA), ethylene glycol dimethacrylate (EGDMA), triethylene glycol diacrylate (TREGDA) and 2-hydroxypropyl acrylate (2-HPA)] in syringes and IQ™ chambers (Chemotechnique Diagnostics, Vellinge, Sweden) were analysed using gel permeation chromatography and high-performance liquid chromatography to measure the allergen content over time in samples stored in the freezer, refrigerator and under room temperature. Results The concentration of allergens in syringes decreased with time. Those stored at room temperature had the fastest rate of decrease, followed by those in the refrigerator and freezer. In most cases, in syringes or IQ™ chambers under all storage conditions, the MMA decreased most rapidly, followed by 2-HPA, 2-HEMA, EGDMA and TREGDA. The allergens in the IQ™ chambers rapidly disappeared, with almost all samples reaching nondetectable levels by day 8. MMA was the first to reach a nondetectable level – at day 2. Conclusions Acrylate/methacrylate allergens are lost rapidly from IQ™ chambers especially if stored at room temperature. Allergens in syringes remain above 80% of their initial concentrations for longer periods compared with IQ™ chambers. In syringes and IQ™ chambers there is a slower rate of decrease in concentration when the storage temperature is lower. Allergens should be stored refrigerated, replaced regularly, and freshly applied on to test patches on the day of use.
MRI-based measurement of hippocampal volume in patients with combat- related posttraumatic stress disorder
Authors: J D Bremner, P Randall, T M Scott, R A Bronen, J P Seibyl, S M Southwick, R C Delaney, G McCarthy, D S Charney, R B Innis
Journal: American Journal of Psychiatry (1995)

Studies in nonhuman primates suggest that high levels of cortisol associated with stress have neurotoxic effects on the hippocampus, a brain structure involved in memory. The authors previously showed that patients with combat-related posttraumatic stress disorder (PTSD) had deficits in short-term memory. The purpose of this study was to compare the hippocampal volume of patients with PTSD to that of subjects without psychiatric disorder.Magnetic resonance imaging was used to measure the volume of the hippocampus in 26 Vietnam combat veterans with PTSD and 22 comparison subjects selected to be similar to the patients in age, sex, race, years of education, socioeconomic status, body size, and years of alcohol abuse.The PTSD patients had a statistically significant 8% smaller right hippocampal volume relative to that of the comparison subjects, but there was no difference in the volume of other brain regions (caudate and temporal lobe). Deficits in short-term verbal memory as measured with the Wechsler Memory Scale were associated with smaller right hippocampal volume in the PTSD patients only.These findings are consistent with a smaller right hippocampal volume in PTSD that is associated with functional deficits in verbal memory.
Abstract 2608: Dyssynchrony Contributes to Left Ventricular Dysfunction after Acute Myocardial Infarction
Authors: Federico M Asch, Szymon P Bieganski, Maureen McNulty, Ken Horton, Neil J Weissman, Julio A Panza
Journal: Circulation (2007)

In patients with acute myocardial infarction (AMI), involved segments may not only show depressed but also delayed contraction, leading to left ventricular dyssynchrony. However, the presence of dy...
Abstract 1482: Curcumin Attenuates Cardiac Hypertrophy and Left Ventricular Remodeling Secondary to Experimental Chronic Renal Failure Independent of Blood Pressure in Nephrectomized Rats
Authors: Siddartha Ghosh, Fadi Salloum, Antonio Abbate, Stefano Toldo, Rakesh C Kukreja
Journal: Circulation (2008)

Background: The prevalence of heart failure (HF) is frequent in patients with chronic renal failure (CRF). One common link between CRF and HF is inflammation. Curcumin, the principal curcuminoid of the Indian curry spice turmeric, is known for its antitumor anti-inflammatory properties. We therefore hypothesized that curcumin would attenuate cardiomyopathy in nephrectomized rats. Methods and Results: Adult Sprague-Dawley rats underwent nephrectomy (Nx) by removal of 5/6 of the kidneys. Four groups were studied for 7 weeks: 1- Control (sham), 2- Nx, 3- Nx + curcumin (75mg/kg; bid), 4- Nx + enalapril (15 mg/kg; bid) as positive control. The systolic blood pressure (SBP, mmHg) of Nx rats was 152±5, significantly higher than control (115±2) and enalapril-treated rats (125±3). Curcumin did not reduce SBP (141±4). BUN (mg/dl) and creatinine (mg/dl) levels of Nx rats (67±7 and 1.92±0.08, respectively) were higher than control (P&lt;0.001). Both curcumin and enalapril significantly reduced BUN (40±2 and 43±4, respectively) and creatinine (0.95±0.05 and 0.77±0.06, respectively) (P&lt;0.001 vs. Nx). Moreover, Nx rats exhibited severe proteinurea (mg/18 hours) (316±36) as compared to controls (34±5) which was blunted by curcumin (183±40, P&lt;0.001) and enalapril (180±17, P&lt;0.001). Right and left cardiac hypertrophy was assessed by weighing the right (RV) and left ventricles (LV) and normalizing with body weight. Nx rats had significant RV and LV hypertrophy (P&lt;0.01). Curcumin and enalapril effectively decreased LV hypertrophy (P&lt;0.05), however, RV hypertrophy was only decreased by curcumin (P&lt;0.05). Echocardiography data revealed a significant increase in LV mass in Nx rats (1.47±0.19) as compared with controls (0.98±0.04, P&lt;0.01). Curcumin and enalapril-treated rats had LV mass of 0.95±0.1 (P&lt;0.01) and 0.93±0.3 (P&lt;0.05), respectively. LV end-diastolic diameter (EDD, mm) was higher in Nx rats (7.2±0.2) as compared to controls (6.4±0.2, P=0.01). Curcumin and enalapril attenuated LV dilatation as shown by EDD of 6.3±0.5 and 6.2±0.5, respectively (P=0.01). Conclusion: These results show that curcumin attenuates cardiac hypertrophy and remodeling in nephrectomized rats independent of BP. Therefore, curcumin may be useful in suppressing HF in patients with CRF.
Pharmacokinetics and Pharmacodynamics of Oral Methotrexate and Mercaptopurine in Children With Lower Risk Acute Lymphoblastic Leukemia: A Joint Children’s Cancer Group and Pediatric Oncology Branch Study
Authors: Frank M. Balis, John S. Holcenberg, David G. Poplack, Jeffrey Ge, Harland N. Sather, Robert F. Murphy, Matthew M. Ames, Mary J. Waskerwitz, David G. Tubergen, Solomon Zimm, Gerald S. Gilchrist, W. Archie Bleyer
Journal: Blood (1998)
Depressive comorbidity in children and adolescents: empirical, theoretical, and methodological issues
Authors: A Angold, E J Costello
Journal: American Journal of Psychiatry (1993)

The purpose of the study was to examine comorbidity in the context of child and adolescent depression.The authors reviewed recent epidemiological studies using standardized interviews and DSM-III or DSM-III-R criteria.There was a high rate of comorbidity in children and adolescents with major depressive disorders or dysthymia. Comorbidity with conduct disorder/oppositional defiant disorder ranged from 21% to 83%; comorbidity with anxiety disorder ranged from 30% to 75%; and comorbidity with attention deficit disorder ranged from 0% to 57.1%. Rates of depressive comorbidity found in community studies were similar to the rates found in clinical studies. In almost all cases, the disorders were more common in depressed children than expected by chance, and the rates of other disorders in depressed children were higher than the rates of depression in those with depression.The mechanisms by which comorbidity occurs are obscure at present. Several possibilities and their implications for nosology, epidemiology, and treatment research are discussed.
Spirometry quality in a secondary care outpatient setting in comparison to physiologists in a lung function lab
Authors: Jessie Matthews, Matthew Rutter, Karl Sylvester
Journal: European Respiratory Journal (2014)

Introduction: A clinical audit assessed the quality of spirometry performed in our respiratory medicine clinic by physicians and nurses. Comparison of results obtained in the clinic(CL) and lung function laboratory(LF) was undertaken.  Aims: To investigate CL spirometry adherence to the ERS/ATS acceptability criteria and, if the acceptability criteria were not being met, whether this caused a significant difference to patients9 results.  Methods: Data was collected retrospectively. The number of manoeuvres, values and type & number of errors per test were recorded. To compare the results between CL and LF the FEV1, FVC, FER, PEF from the best manoeuvre in each test from 40 individuals, who had had tests in both settings, were compared and a T-test used to statistically analyse any significant differences.  Results: Of 1008 tests, 778 (77.18%) performed   Conclusions: The data demonstrated a high proportion of spirometry performed in CL did not meet standards outlined by the ERS/ATS guidelines; specifically, insufficient number of manoeuvres per test and a high number of errors. Significant differences in some parameters could result in mis-diagnosis or differing severity classification. Further analysis is needed to see whether there is a correlation between the number of manoeuvres performed and the impact on values gained.
COPD heterogeneity: An epidemiological perspective from the PLATINO study
Authors: M. Victorina Lopez Varela, Maria Montes de Oca, Adriana Muiño, Carlos Talamo, Dolores Moreno, Ana Menezes, Rogelio Perez Padilla, Jose Jardim, Gonzalo Valdivia, Julio Pertuze, Ron Halbert
Journal: European Respiratory Journal (2011)

PLATINO offers an opportunity to characterise COPD heterogeneity in a population-based multicenter study. 759 COPD and 4,554 non-COPD individuals were included. COPD was characterised for potential phenotypes.  Dyspnea, health status (HS) and physical limitations  similar in non-obstructed and stage-1. mMRC (2+) and physical limitations were reported by 61.2% and 27.1% of stage-2, vs 80.8% and 55.8% of stage-3&4 patients, respectively. Good-excellent HS was reported in 58.6% of stage-2 vs 32.6% of stages-3&4 individuals.  BMI:  higher proportion of COPD were in underweight-normal vs. obese category (27.4 vs 10.9%). A subgroup of severe COPD reported dyspnea mMRC 1, no physical limitation, or were obese.  Acute bronchodilator responsiveness  (ABR): was present in 51.2% of stage-1 vs 6.8% of stages-3&4 (p Exacerbations:  increased from 4.2% in stage-1 to 28.9% in stages- 3&4 (present on a subgroup of subjects).  Gender:  females vs men reported more fair-poor HS (40 vs 28%, p Co-morbidities:  females had a higher co-morbidity score (1.35±0.1 vs 1.01±0.1, p Chronic bronchitis:  was present in 8.56% of COPD, preponderance in males 65.5% (p=0.01) and current smokers 47.6% (p=0.005).  In conclusion, PLATINO data show a significant COPD heterogeneity even at same severity stages. A better understanding of potential phenotypes should probably come through the follow up “PLATINO Cohort Study”.
Model-based analysis of oligonucleotide arrays: model validation, design issues and standard error application
Authors: Cheng Li, Wing Hung Wong
Journal: Genome biology (2001)

A model-based analysis of oligonucleotide expression arrays we developed previously uses a probe-sensitivity index to capture the response characteristic of a specific probe pair and calculates model-based expression indexes (MBEI). MBEI has standard error attached to it as a measure of accuracy. Here we investigate the stability of the probe-sensitivity index across different tissue types, the reproducibility of results in replicate experiments, and the use of MBEI in perfect match (PM)-only arrays. Probe-sensitivity indexes are stable across tissue types. The target gene's presence in many arrays of an array set allows the probe-sensitivity index to be estimated accurately. We extended the model to obtain expression values for PM-only arrays, and found that the 20-probe PM-only model is comparable to the 10-probe PM/MM difference model, in terms of the expression correlations with the original 20-probe PM/MM difference model. MBEI method is able to extend the reliable detection limit of expression to a lower mRNA concentration. The standard errors of MBEI can be used to construct confidence intervals of fold changes, and the lower confidence bound of fold change is a better ranking statistic for filtering genes. We can assign reliability indexes for genes in a specific cluster of interest in hierarchical clustering by resampling clustering trees. A software dChip implementing many of these analysis methods is made available. The model-based approach reduces the variability of low expression estimates, and provides a natural method of calculating expression values for PM-only arrays. The standard errors attached to expression values can be used to assess the reliability of downstream analysis.
Paul William Joy
Authors: R. Joy
Journal: BMJ (2015)

Paul William Joy worked as a partner at Rhayader Surgery, a small practice in rural mid-Wales for 25 years, until he retired because of ill health in March 2014. After enjoying GP training in Talgarth, Powys, he joined Rhayader Surgery in 1988. During his first 15 years with the practice, he and his partners provided continuous 24 hour cover for a large rural area, including all community intrapartum care, until the launch of midwifery led care in 2001. 

In …
Planning for the Development of Comprehensive Community Alcoholism Services: I. The Prevalence Survey
Authors: ALLAN BEIGEL, E. JAMES HUNTER, JOHN S. TAMERIN, EDWIN H. CHAPIN, MARY J. LOWERY
Journal: American Journal of Psychiatry (1974)

The authors point out that there is a great need for adequate prevalence data in the planning of comprehensive community alcoholism programs and that such planning must be based on the needs of the specific community. They present a method for obtaining useful prevalence data in a brief period of time and at a modest cost, giving examples of how these data can be used in planning a rational program for a specific community.
Proximate effects of sexual abuse in childhood: a report on 28 children
Authors: Christine Adams-Tucker
Journal: American Journal of Psychiatry (1982)

Of 28 sexually abused children (22 girls and 6 boys) aged 21/2 to 151/2 years, those suffering moderate to extreme emotional disturbance were female, unsupported by a close adult, molested by their father and by more than one male relative, genitally molested, and molested from an early age and over a long period. Twelve children were referred for psychiatric evaluation due to sexual abuse without apparent symptoms, and 5 solely due to symptoms, with sexual abuse unknown. The author suggests that child mental health professionals should improve their skills for identifying sexually abused children and help parents to be supportive of such children.
Therapy of human tumors in NOD/SCID mice with patient-derived reactivated memory T cells from bone marrow
Authors: Markus Feuerer, Philipp Beckhove, Lianhua Bai, Erich-Franz Solomayer, Gunther Bastert, Ingo J. Diel, Claudia Pedain, Michael Oberniedermayr, Volker Schirrmacher, Victor Umansky
Journal: Nature Medicine (2001)
Abstract 17041: The Role of Mumps Virus in the Etiology of Endomyocardial Fibrosis
Authors: Brian Kolski, Xing-Quan Zhang, Anna O Mocumbi, Maria B Ferreira, Daniel G Blanchard, Kirk Knowlton, Robert T Schey
Journal: Circulation (2010)

Background: Endomyocardial fibrosis (EMF) is the most common worldwide cause of restrictive cardiomyopathy. It is estimated to cause clinically significant disease in over 10,000,000 people residing in sub-tropical, and tropical climates worldwide in the developing world. In our research cohort from a rural area in Mozambique, EMF's prevalence was estimated at 19.8%. Pathologically EMF biopsy and autopsy specimens closely resemble endomyocardial fibroelastosis (EFE), a disease seen in neonates. In previous work there was an association with EFE and mumps virus detected in myocardial autopsy tissue. Additional work has shown a 42% prevalence of cardiotropic viruses (Ebstein-Barr, Coxsackie, etc.) measured by PCR of surgically resected ventricular endomyocardium from EMF patients. Our objective was to determine whether mumps virus plays an etiologic role in EMF, by isolating the virus from surgical resected endomyocardium. Methods: We analyzed 12 endomyocardial biopsies from previous decortication procedure...
The clearance of CD34+ cells from peripheral blood (PB) after peripheral blood hematopoietic stem cell (PBHSC) infusion is correlated with the hematologic recovery (HR).
Authors: Linda Dhondt, Yves Humblet, M Andree, J Wuu, C vanLerberghe, T. Guillaume, Anne Marie Feyens, A. Dromelet, Bernard Chatelain, Jacques Longueville, Michel Symann
Journal: Blood (1997)
Concomitant latent tuberculosis in patients with lung cancer
Authors: Wei-Juin Su, Wen-Chien Fan, Jia-Yih Feng, Shiang-Fen Huang
Journal: European Respiratory Journal (2014)

Background:   Tuberculosis (TB) appears to be a risk factor for lung cancer, but whether or not it is the cause is still uncertain. Patients with latent TB infection (LTBI) are vulnerable to develop active TB, however, the relationship between lung cancer and LTBI is not well understood.    Methods:   We conducted a prospective study of 340 newly diagnosed lung cancer patients from four medical centers in Taiwan. LTBI was detected by using QuantiFERON-TB Gold In-Tube (QFT-GIT) assay. Demographic data and cancer-related factors associated with LTBI were investigated. The survival status was also analyzed according to the status of LTBI.    Results:   Of 340 lung cancer patients, LTBI was detected in 96 (28.2%), and 30 (8.8%) showed indeterminate results of QFT-GIT. Non-adenocarcinoma cases had higher proportion of LTBI than those of adenocarcinoma, especially in patients with younger age. In multivariate analysis, COPD (OR 2.41, 95% CI 1.25-4.64), fibrocalcified lesions on chest radiogram (OR 2.73, 95% CI 1.45-5.11), and tumor growth in areas common for TB (OR 2.02, 95% CI 1.15-3.55) were independent clinical predictors for LTBI. In multivariate analysis, independent predictors for one-year all-cause mortality included BMI     Conclusions:   The results suggest that LTBI is common among lung cancer patients in Taiwan. Co-existence of COPD, fibrocalcified lesions on chest radiogram, and tumor growth in areas common for TB are associated with LTBI. However, indeterminate QFT-GIT result was an independent predictor for all-cause mortality in lung cancer patients.