SYMPTOMATIC HEMOLYTIC ANEMIA
Authors: Karl Singer, William Dameshek
Journal: Annals of Internal Medicine (1941)

Article1 September 1941SYMPTOMATIC HEMOLYTIC ANEMIAKARL SINGER, M.D., WILLIAM DAMESHEK, M.D., F.A.C.P.KARL SINGER, M.D.Search for more papers by this author, WILLIAM DAMESHEK, M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-15-3-544 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptIn their recent review of acute hemolytic anemia, Dameshek and Schwartz7a classify hemolytic anemia as follows:A. CongenitalB. Acquired1. Secondary to known cause (infectious, chemical, "toxic," pregnancy, etc.);2. Symptomatic, in association with certain, usually malignant diseases, as lymphatic leukemia, Hodgkin's disease, carcinomatosis;3. Of unknown cause, with or without hemolysins in the serum.Symptomatic hemolytic anemia may be defined as a hemolytic syndrome often indistinguishable by hematological methods from the well-known picture of familial hemolytic jaundice, but showing a definite etiological relationship to such underlying diseases as neoplasm (teratoma, sarcoma), leukemia, and Hodgkin's disease. Frequently but not...Bibliography1. AUBFAIRHALLMINOTREZNIKOFF JCLTASP: Lead poisoning, Medicine, 1925, iv, 1. Google Scholar2. BENSISGOUTTAS WA: Lymphogranulomatose maligne. Terminaison par l'anémie grave, Sang, 1934, viii, 288. Google Scholar3. VAN DEN BERGHKAMERLING AAAW: Un cas de cirrhose hépatique accompagnée d'anémie hémolytique et d'une hématinémie massive, Ann. d. Méd., 1935, xxxviii, 309. Google Scholar4. VON BRAITENBERG H: Lymphogranulomatose mit hämolytisch anämischen Syndrom, Frankfurt. Ztschr. f. Path., 1937-38, li, 515. Google Scholar5. BRUINS SLOT WJ: Hemolytic anemia in malignant lymphogranuloma, Nederl. Tijdschr. v. Geneesk., 1938, lxxxii, 38. Google Scholar6. CAROLILAVERGNE JH: Ictère hémolytique aigu par carcinomatose de la moelle osseuse secondaire à un cancer de l'estomac, Bull. et mém. Soc. méd. d. hôp. de Paris, 1937, ii, 1056. Google Scholar7a. DAMESHEKSCHWARTZ WSO: Acute hemolytic anemia, Medicine, 1940, xix, 231. CrossrefGoogle Scholar7b. DAMESHEKSCHWARTZ WSO: Hemolysins as the cause of clinical and experimental anemia, Am. Jr. Med. Sci., 1938, cxcvi, 769. CrossrefGoogle Scholar7c. DAMESHEK W: Target cell anemia, Am. Jr. Med. Sci., 1940, cc, 445. CrossrefGoogle Scholar7d. DAMESHEKMILLER WEB: The pathogenesis of hemolytic anemia. (Unpublished data.) Google Scholar8a. DAVIDSONFULLERTON LSHW: Macrocytic anemia with hemolysis in liver cirrhosis, Quart. Jr. Med., 1938, vii, 43. Google Scholar8b. DAVIDSON LS: Macrocytic hemolytic anemia, Quart. Jr. Med., 1932, xxv, 543. Google Scholar9. ENGELBRETH-HOLM J: A study of tuberculous splenomegaly and splenogenic controlling of the cell emission from the bone-marrow, Am. Jr. Med. Sci., 1938, cxcv, 32. CrossrefGoogle Scholar10. EPPINGER H: Hepatolineale Erkrankungen, 1920, Springer, Berlin. Google Scholar11. FELLINGERKLIMA KR: Untersuchungen ueber Anämien bei Leberzirrhosen, Ztschr. klin. Med., 1934, cxxvi, 547. Google Scholar12. FREUND M: Hemolytic jaundice not influenced by splenectomy, Am. Jr. Dis. Child., 1932, xliii, 645. Google Scholar13. GIFFIN HZ: Tuberculosis of spleen, Med. Clin. N. Am., 1919, iii, 765. Google Scholar14a. GRIPWALL E: Zur Klinik und Pathologie des hereditaeren haemolytischen Ikterus, Acta med. Scand., 1938, supplementun xcvi. Google Scholar14b. GRIPWALL E: Operierter Fall einer bei uns unbekannten Art von Splenomegalie, Acta med. Scand., 1932, lxxix, 489. Google Scholar14c. BERGQUISTGRIPWALL BE: Beiträge zur Kenntnis der Differentialdiagnose zwischen Splenogranulomatosis siderotica und Lymphogranulomatose, Acta Path. et Microbiol. Scand., 1935, xii, 79. Google Scholar15a. HADEN RL: Mechanism of increased fragility of the red blood cells in congenital hemolytic jaundice, Am. Jr. Med. Sci., 1934, clxxxviii, 411. Google Scholar15b. HADEN RL: The nature of hemolytic anemia. A Symposium, 1939, U. Wisconsin Press, Madison. Google Scholar15c. HADEN RL: Principles of hematology, 1939, Lea and Febiger, Philadelphia. Google Scholar15d. HADENEVANS RLFD: Sickle cell anemia in the white race, Arch. Int. Med., 1937, lx, 133. CrossrefGoogle Scholar16a. HAM TH: Studies on destruction of red blood cells. I. Chronic hemolytic anemia with paroxysmal nocturnal hemoglobinuria, Arch. Int. Med., 1939, lxiv, 1271. CrossrefGoogle Scholar16b. HAMCASTLE THWB: Relation of increased hypotonic fragility and of erythrostasis to the mechanism of hemolysis in certain anemias, Proc. Phil. Soc., 1940, lxxxii, 411. Google Scholar17. HARVEYJANEWAY AMCA: The development of acute hemolytic anemia during administration of sulfanilamide, Jr. Am. Med. Assoc., 1937, cix, 12. CrossrefGoogle Scholar18. HEILMEYERALBUS LL: Die hämolytische Hypersplenie, Deutsch. Arch. klin. Med., 1935, clxxviii, 89. Google Scholar19. HOLLERPASCHKIS GK: Abdominale Form des Lymphogranuloms, Wien. Arch. inn. Med., 1927, xiv, 149. Google Scholar20. HOWELLS L: Tuberculous splenomegaly, Brit. Jr. Tuberc., 1939, xxxiii, 178. CrossrefGoogle Scholar21. KAMINERROHNSTEIN SR: Ueber Phenylhydrazinanämie, Berl. klin. Wchnschr., 1900, xxxi, 687. Google Scholar22. KLIMA R: Hemolytische Anämie in Leukämie, Wien. Arch. inn. Med., 1935, xxvi, 277. Google Scholar23. KNISELY MH: Spleen studies. I. Microscopic observations of the circulating system of living unstimulated mammalian spleens, Anat. Rec., 1936, lxv, 23; II. Microscopic observations of the circulating system of living traumatized spleens and of dying spleens, ibid., 1936, lxv, 131. CrossrefGoogle Scholar24. KOHN SE: Anemia during treatment with sulfanilamide, Jr. Am. Med. Assoc., 1937, cix, 1005. CrossrefGoogle Scholar25. KWASZEWSKA G: Hämolytische Anämie und Lymphogranulomatose, Wien. klin. Wchnschr., 1931, 684. Google Scholar26. MARCHALLDANYGRUPPER G: Ictère et anémie hémolytiques avec myélémé (rouge et leucémie lymphoide a forme splénomegalique), Sang, 1934, viii, 852. Google Scholar27. NAEGELI O: Blutkrankheiten und Blutdiagnostik, 1931, Julius Springer, Berlin. CrossrefGoogle Scholar28. PARKES-WEBERSCHWARZ FE: Severe relapsing anemia in case apparently of Hodgkin's disease, Lancet, 1934, i, 680. CrossrefGoogle Scholar29. PASCHKIS K: Ueber atypische hämolytische Anämien, Ztschr. f. klin. Med., 1927, cv, 301. Google Scholar30. RHOADS CP: Aplastic anemia. In a symposium, 1939, U. Wisconsin Press, Madison. Google Scholar31. ROSENBERG DM: Macrocytic anemia in liver disease particularly cirrhosis, Am. Jr. Med. Sci., 1936, cxcii, 86. CrossrefGoogle Scholar32. SCHIAPOLLI F: Granuloma malignum localized in liver and spleen with hemolytic anemia, Minerva Med., 1934, i, 575. Abstract in Am. Jr. Cancer, 1936, xxvi, 874. Google Scholar33. SEYDERHELMLEHMANNWICHELS RWP: Intestinale perniziöse Anaemie beim Hund durch experimentelle Dünndarmstriktur, Krankheitsforschung, 1927, iv, 263. Google Scholar34a. SINGER K: The lysolecithin fragility test, Am. Jr. Med. Sci., 1940, cxcix, 466. CrossrefGoogle Scholar34b. SINGER K: Das Problem der Milzhämolyse, Wien. Arch. inn. Med., 1937, xxxi, 59. Google Scholar34c. SINGER K: Ueber das hämolytische Syndrom als klinische Erscheinungsform des Lymphogranuloms, Med. Klin., 1936, xxxii, 179. Google Scholar34d. SINGERMILLERDAMESHEK KEBW: Hematological changes following splenectomy, Am. Jr. Med. Sci., 1941, ccii, 171. CrossrefGoogle Scholar35. SUAREZETCHEVERRY CVMA: A ciste dermoidea del hilio esplenico esplenomegalia icterica hemolitica y anemia grava, Arch. argent. de enferm. d. ap. digest. y de la nutrición, 1936-37, xii, 168. Google Scholar36a. THOMPSON WP: Hemolytic jaundice, Bull. N. Y. Acad. Med., 1939, xv, 177. Google Scholar36b. THOMPSON WP: Hemolytic jaundice, Jr. Am. Med. Assoc., 1936, cvii, 1776. CrossrefGoogle Scholar37. TROISIERTIXIER JL: Quoted by Marchall et al. Google Scholar38a. WATSON GJ: Hemolytic jaundice and macrocytic hemolytic anemia, ANN. INT. MED., 1939, xii, 1782. Google Scholar38b. WATSON GJ: Studies of urobilinogen. I-III. Am. Jr. Clin. Path., 1936, vi, 458; Arch. Int. Med., 1937, lix, 196, 206. CrossrefGoogle Scholar38c. WATSON GJ: The pyrrol pigments with particular reference to normal and pathological hemoglobin metabolism, in Downey's Handbook of Hematology, 1938, Paul B. Hoeber and Co., 4, Sec. 35, 2447. Google Scholar39. WAUGH TR: Hemolytic anemia in carcinomatosis of the bone marrow, Am. Jr. Med. Sci., 1936, cxci, 160. CrossrefGoogle Scholar40. WEST-WATSONYOUNG NCJ: Failed splenectomy in acholuric jaundice and the relation of toxemia to hemolytic crises, Brit. Med. Jr., 1938, i, 1305. CrossrefGoogle Scholar41. WIDALABRAMIBRULÉ FPM: Pluralité d'origine des icteres hémolytiques recherches cliniques et expérimentales, Bull. et mém. Soc. méd. d. hôp. de Paris, 1907, xxiv, 1354. Google Scholar42a. WINTROBE MM: Relation of disease of liver to anemia, Arch. Int. Med., 1936, lvii, 289. CrossrefGoogle Scholar42b. WINTROBESHUMAKER MMHS: The occurrence of macrocytic anemia in disorders of the liver, Bull. Johns Hopkins Hosp., 1933, lii, 387. Google Scholar43. WRIGHT DO: Macrocytic anemia and hepatic cirrhosis, Am. Jr. Med. Sci., 1935, clxxxix, 115. CrossrefGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: *Received for publication March 27, 1941.From the Joseph H. Pratt Diagnostic Hospital, and the Blood Clinic of the Boston Dispensary.Aided by grants from the Dazian Foundation, and the Charlton Fund, Tufts College Medical School. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byTraitement chirurgical d’une anémie hémolytique auto-immuneAnemia hemolítica autoinmunitaria asociada a quiste benigno de ovarioSarcoidosis Presenting With Cystic Lung Lesions and Autoimmune Hemolytic AnemiaClassification and Clinical Characteristics of Autoimmune Hemolytic AnemiasThe immune haemolytic anaemias: a century of exciting progress in understandingAutoimmune hemolytic anemia and dermoid cyst of the mesentery: A case reportAutoimmune hemolytic anemia and ovarian dermoid cysts: Case report and review of the literatureCase 24-1978Hemolytic anemia associated with an ovarian tumorAutoimmune Haemolytic Anaemia and Ovarian TumourDie hämolytischen AnämienAutoimmune haemolytic anaemia associated with ovarian dermoid cystAutoimmunhämolytische Anämie im Säuglingsalter in Begleitung einer HepatitisCoombs'-positive Hemolytic Anemia in Hodgkin's DiseaseERIC EISNER, M.D., ALLYN B. LEY, M.D., KLAUS MAYER, M.D., F.A.C.P.Ovarian neoplasm associated with autoimmune hemolytic anemiaHEMOLYTIC ANEMIADas h�molytische Syndrom bei der akuten und chronischen HepatitisAutoimmunization and other types of indirect damage to host cells as factors in certain protozoan diseasesUntersuchungen �ber den Blutumsatz bei posthepatitischen und anderen funktionellen Hyperbilirubin�mienErworbene hämolytische AnämieInhibitory Action of Serum Lecithin on the Hemolytic Activity of Serum Lysolecithin in VitroDas Blut als OrganSerologie und Klinik der autoimmunhämolytischen ErkrankungenDie Bedeutung des Properdinsystems f�r den normalen und gesteigerten BlutzellabbauAnemia In CancerAUTO-IMMUNE HEMOLYTIC ANEMIA ARRESTED BY REMOVAL OF AN OVARIAN TERATOMA: REVIEW OF THE LITERATURE AND REPORT OF A CASE*KEVIN G. BARRY, WILLIAM H. CROSBYTreatment of Symptomatic Hemolytic Anemia with PrednisoneChronic lymphocytic leukemia associated with dysproteinemia and acquired hemolytic anemiaDie Pathologie des Stoffwechsels der SchwermetalleSCLERODERMA WITH SYMPTOMATIC HEMOLYTIC ANEMIA: A CASE REPORT*HUGH FUDENBERG, M.D., M. M. WINTROBE, M.D., F.A.C.P.Symptomatic and hemopathic hemolytic anemiaAnaemia in Systemic DiseasesThe Syndrome of High-Titre Cold Hemagglutination.Immrino-IIeruolytic Anemia in Kaposi's Snrcoiiin with Visceral Involveriient only.Beobachtungen zu Krankheitsbild, Pathogenese und �tiologie der akuten erworbenen h�molytischen An�mie (Lederer-An�mie)Die Krankheiten der Leber und der GallenwegeAntikörperbedingte hämolytische AnämienHÆMOGLOBINURIA IN TYPHOID FEVER TREATED WITH CHLORAMPHENICOLSymptomatic Haemolytic Anaemia Associated with Ovarian Teratoma in a ChildThe Treatment of Acquired Hemolytic Anemia: With a Note on The Relationship of Periarteritis Nodosa to Hemolytic AnemiaThe Treatment of Acquired Hemolytic Anemia with Adrenocorticotrophic Hormone (ACTH)Laboratory Diagnosis of Polycythemia and AnemiaSplenectomy in LeukemiaHematologySplenectomy for Acquired Hemolytic Jaundice in the AgedAcute Acquired Hemolytic AnemiaHÆMOLYTIC ANÆMIA DUE TO SULPHAPYRIDINE 1 September 1941Volume 15, Issue 3Page: 544-563KeywordsBloodCarcinomatosisHematology and oncologyHemolytic anemiaHemolytic jaundiceHodgkin lymphomaHospitalsPregnancySarcoma ePublished: 1 December 2008 Issue Published: 1 September 1941 PDF downloadLoading ...