tbuckley/cabot-search huggingface dataset:
Systolic mechanical performance of heterotopically transplanted hearts in rats treated with cyclosporin
Authors: F. Kolar, C. MacNaughton, F. Papousek, B. Korecky
Journal: Cardiovascular Research (1993)

Journal Article Systolic mechanical performance of heterotopically transplanted hearts in rats treated with cyclosporin Get access František Kolář, František Kolář Department of Physiology, University of Ottawa Health Sciences Centre, Ottawa, Ontario, Canada: C MacNaughton, B Korecky; Department of Developmental Cardiology, Institute of Physiology, Czechoslovak Academy of Sciences, Prague, Czechoslovakia: F Kolář, F Papoušek. Correspondence to Dr Kolář. Search for other works by this author on: Oxford Academic PubMed Google Scholar Cathy MacNaughton, Cathy MacNaughton Department of Physiology, University of Ottawa Health Sciences Centre, Ottawa, Ontario, Canada: C MacNaughton, B Korecky; Department of Developmental Cardiology, Institute of Physiology, Czechoslovak Academy of Sciences, Prague, Czechoslovakia: F Kolář, F Papoušek. Search for other works by this author on: Oxford Academic PubMed Google Scholar František Papoušek, František Papoušek Department of Physiology, University of Ottawa Health Sciences Centre, Ottawa, Ontario, Canada: C MacNaughton, B Korecky; Department of Developmental Cardiology, Institute of Physiology, Czechoslovak Academy of Sciences, Prague, Czechoslovakia: F Kolář, F Papoušek. Search for other works by this author on: Oxford Academic PubMed Google Scholar Borivoj Korecky Borivoj Korecky Department of Physiology, University of Ottawa Health Sciences Centre, Ottawa, Ontario, Canada: C MacNaughton, B Korecky; Department of Developmental Cardiology, Institute of Physiology, Czechoslovak Academy of Sciences, Prague, Czechoslovakia: F Kolář, F Papoušek. Search for other works by this author on: Oxford Academic PubMed Google Scholar Cardiovascular Research, Volume 27, Issue 7, July 1993, Pages 1244–1247, https://doi.org/10.1093/cvr/27.7.1244 Published: 01 July 1993 Article history Received: 26 October 1992 Accepted: 19 January 1993 Published: 01 July 1993
David Richard Kilvington Street
Authors: Elizabeth Cooke
Journal: BMJ (2006)

David Richard Kilvington Street qualified in 1943, becoming a house physician at Leeds General Infirmary until 1944, when he moved to Pinderfields Emergency Hospital, Wakefield. For eight months he was involved in general, ear, nose, and throat, and thoracic surgery. Between 1944 and 1946 he was the clinical assistant in the neurological …
Effect of a fibrinolytic agent (Arvin) on wound healing and collagen formation.
Authors: P J Holt, V Holloway, N Raghupati, J S Calnan
Journal: Annals of the Rheumatic Diseases (1970)

Heberden Society 335 luxation is more common than we think is tenable, I cannot say.The onus lies with those who treat their patients without fusion to show that their method is as safe as surgery.
Diving and the risk of barotrauma
Authors: E. W. Russi
Journal: Thorax (1998)

STUDY OBJECTIVES: Pulmonary barotrauma (PBT) of ascent is a feared complication in compressed air diving. Although certain respiratory conditions are thought to increase the risk of suffering PBT and thus should preclude diving, in most cases of PBT, risk factors are described as not being present. The purpose of our study was to evaluate factors that possibly cause PBT. DESIGN: We analyzed 15 consecutive cases of PBT with respect to dive factors, clinical and radiologic features, and lung function. They were compared with 15 cases of decompression sickness without PBT, which appeared in the same period. RESULTS: Clinical features of PBT were arterial gas embolism (n = 13), mediastinal emphysema (n = 1), and pneumothorax (n = 1). CT of the chest (performed in 12 cases) revealed subpleural emphysematous blebs in 5 cases that were not detected in preinjury and postinjury chest radiographs. A comparison of predive lung function between groups showed significantly lower midexpiratory flow rates at 50% and 25% of vital capacity in PBT patients (p &lt; 0.05 and p &lt; 0.02, respectively). CONCLUSIONS: These results indicate that divers with preexisting small lung cysts and/or end-expiratory flow limitation may be at risk of PBT.
Survival after liver transplansplantation of patients with PBC in the Nordic countries: Comparison to expected survival 1. From another series of transplantations and 2. To an international trial of medical treatment
Authors: S Keiding, B-G Ericzon, S Eriksson, A Flatmark, K Hockerstedt, H Isoniemi, I Karlberg, N Keiding, R Olsson, K Salmela, E Schrumpf, C Soderstrom
Journal: Journal of Hepatology (1989)
CLINICAL OUTCOME OF TRANSCATHETER AORTIC VALVE IMPLANTATION AFTER PRIOR CORONARY BYPASS
Authors: Eran Leshem-Rubinow, Yigal Abramowitz, Arie Steinvil, Eyal Ben- Assa, Maayan Konigstein, Gad Keren, Shmuel Banai, Ariel Finkelstein
Journal: Journal of the American College of Cardiology (2014)
Rarity of synovitis in polymyalgia rheumatica.
Authors: V Kyle, J Tudor, E P Wraight, G A Gresham, B L Hazleman
Journal: Annals of the Rheumatic Diseases (1990)

The joints of 56 patients with polymyalgia rheumatica were examined for evidence of inflammatory synovitis. x Rays, isotope scans, and thermography supplemented clinical examination. Control sternoclavicular joints were examined at necropsy. Peripheral and axial synovitis were uncommon and the results contrast with the findings of several recent studies.
Cutaneous side-effects in patients with rheumatic diseases during application of tumour necrosis factor-? antagonists
Authors: H-H. Lee, I-H. Song, M. Friedrich, A. Gauliard, J. Detert, J. Röwert, H. Audring, S. Kary, G.-R. Burmester, W. Sterry, M. Worm
Journal: British Journal of Dermatology (2007)

Patients with rheumatic diseases receiving antitumour necrosis factor (TNF)-alpha-based treatment may develop cutaneous reactions.To analyse the new onset or aggravation of skin lesions in patients with a rheumatic disease during treatment with TNF-alpha antagonists.We conducted a prospective analysis of 35 of 150 patients with a long history of rheumatic disease, including rheumatoid arthritis, ankylosing spondylitis (Bechterew's disease) and psoriatic arthritis, to test for the development of cutaneous manifestations during anti-TNF-alpha (infliximab, adalimumab or etanercept) treatment.Chronic inflammatory skin diseases such as psoriasis and eczema-like manifestations represented the majority of cases (16 of 35). Cutaneous infections caused by viral, bacterial and fungal agents were also observed in many patients (13 of 35). Skin diseases such as dermatitis herpetiformis, leucocytoclastic vasculitis and alopecia occurred in single cases only.We observed a broad, diverse clinical spectrum with a majority of chronic inflammatory and infectious skin diseases. However, we did not identify individual risk factors and a discontinuation of the anti-TNF-alpha treatment was not necessary if adequate dermatological treatment was performed. The onset of cutaneous side-effects in anti-TNF-alpha-based treatments should be determined by nationwide registries.
"Hot Sopt" on Perfusion Lung Scan Produced by Bronchiolo-Alveolar Cell Carcinoma
Authors: B RAMA RAO, RICHARD F. SCHILLACI, FREDERIC H. GERBER, ROBERT F. SARLIN
Journal: Clinical Nuclear Medicine (1982)

RAO, B RAMA CAPT. M.C., U.S.N.; SCHILLACI, RICHARD F. CAPT. M.C., U.S.N.; GERBER, FREDERIC H. CAPT. M.C., U.S.N.; SARLIN, ROBERT F. C.D.R., M.C., U.S.N. Author Information
Doctors' perceptions of palliative care for heart failure: focus group study
Authors: B. Hanratty
Journal: BMJ (2002)

To identify doctors' perceptions of the need for palliative care for heart failure and barriers to change.Qualitative study with focus groups.North west England.General practitioners and consultants in cardiology, geriatrics, palliative care, and general medicine.Doctors supported the development of palliative care for patients with heart failure with the general practitioner as a central figure. They were reluctant to endorse expansion of specialist palliative care services. Barriers to developing approaches to palliative care in heart failure related to three main areas: the organisation of health care, the unpredictable course of heart failure, and the doctors' understanding of roles. The health system was thought to work against provision of holistic care, exacerbated by issues of professional rivalry and control. The priorities identified for the future were developing the role of the nurse, better community support for primary care, and enhanced communication between all the health professionals involved in the care of patients with heart failure.Greater consideration should be given to the care of patients dying with heart failure, clarifying the roles of doctors and nurses in different specialties, and reshaping the services provided for them. Many of the organisational and professional issues are not peculiar to patients dying with heart failure, and addressing such concerns as the lack of coordination and continuity in medical care would benefit all patients.
Physiology of bone: mineral compartment proteins as candidates for environmental perturbation by lead.
Authors: J J Sauk, M J Somerman
Journal: Environmental Health Perspectives (1991)

Termine et al. first demonstrated that sequential dissociative extraction and fractionation procedures with protease inhibitors could provide a convenient approach for the study of mineral compartment constituents. The primary extraction regimen used 4 M guanidine HCl to remove most of the protein from the nonmineralized phase of bone. Subsequently, EDTA-guanidine was used to remove the mineral-phase components. These methods discriminate on the basis of physical-chemical association with a mineral phase rather than on the specific gene products of a particular cell. In the present discussion emphasis is directed at a group of divalent cation binding proteins isolated from the mineral compartment of bone. The localization, synthesis, and chemical characteristics of osteonectin, bone sialoproteins I and II, and bone acidic glycoprotein-75 are discussed and offered as possible sites for perturbation by the environment with lead exposure.
Dexamethasone inhibition of interleukin 1 beta production by human monocytes. Posttranscriptional mechanisms.
Authors: J A Kern, R J Lamb, J C Reed, R P Daniele, P C Nowell
Journal: Journal of Clinical Investigation (1988)

Dexamethasone is known to have an inhibitory effect on IL-1 production. To determine the mechanism(s) of this inhibition, adherent human blood monocytes were stimulated with Escherichia coli lipopolysaccharide (LPS) (10 micrograms/ml) in the presence of dexamethasone. Nuclear transcription run-off assays showed that LPS induced IL-1 beta gene transcription two- to fourfold and that this induction was unaffected by dexamethasone exposure (10(-5) M). The lack of dexamethasone's transcriptional effects was further supported by the absence of any significant change in IL-1 beta mRNA accumulation between LPS-stimulated monocytes exposed or unexposed to dexamethasone, as determined by Northern blot analysis. Posttranscriptionally, dexamethasone was found to have multiple effects: slight prolongation of IL-1 beta mRNA half-life, moderate inhibition of translation of the IL-1 beta precursor, and profound inhibition of the release of IL-1 beta into the extracellular fluid. The data indicate that IL-1 beta is first translated as the 33,000-D pro-IL-1 beta protein, the predominant intracellular form, and the processed to a 17,500-D IL-1 beta protein before or during extracellular transport. The major inhibitory effects of dexamethasone appear to be directed at the translational and posttranslational steps involved in these events.
A New Index of Insulin Sensitivity Obtained From the Oral Glucose Tolerance Test Applicable to Advanced Type 2 Diabetes
Authors: Masao Kanauchi
Journal: Diabetes Care (2002)

Matthews et al. (1) demonstrated that the homeostasis model assessment of insulin resistance (HOMA-IR) is closely correlated with the insulin sensitivity index assessed by euglycemic clamp in only a few patients with type 2 diabetes. Emoto et al. (2) and Bonora et al. (3) also reported that HOMA-IR provided a good correlation in the clamp studies in a relatively greater number of diabetic subjects. However, it has been recognized among some investigators that the HOMA-IR shows relatively low value when the insulin secretion decreases in patients with advanced type 2 diabetes, because the HOMA-IR is a product of fasting glucose and insulin levels. On the other hand, several investigators have recently proposed methods to assess insulin sensitivity using an oral glucose tolerance test (OGTT). Stumvoll et al. (4) disclosed that the OGTT can assess insulin sensitivity in nondiabetic subjects. Even in type 2 diabetes, an index proposed by Matsuda and DeFronzo (5) was correlated to clamp-derived insulin sensitivity. Although these parameters from the OGTT decrease with worsening of glucose tolerance, the values inversely increase once the total insulin secretion declined. They have not been fully validated in Japanese subjects, …
High proximal migration rate of a partially covered “big cup” duodenal stent in patients with malignant gastric outlet obstruction
Authors: Maarten van den Berg, Daisy Walter, Frank Vleggaar, Peter Siersema, Paul Fockens, Jeanin van Hooft
Journal: Endoscopy (2013)

Endoscopic placement of self-expandable metal stents (SEMS) has emerged as a palliative treatment for patients with malignant gastric outlet obstruction (GOO). Recently, a new partially covered "big cup" SEMS has been developed to prevent both stent migration and tissue ingrowth. The aim of the study was to evaluate safety and efficacy of this SEMS in a cohort of patients with incurable malignant GOO. The study was terminated prematurely due to three proximal stent migrations in six patients. Migrations occurred at 2, 4, and 29 days, respectively, and necessitated endoscopic removal and placement of another SEMS. The remaining three patients had a patent SEMS at the end of follow-up. The high proximal migration rate of this new SEMS should be taken into account when considering routine clinical use in malignant GOO. Further research is warranted in order to find an optimal stent design that prevents both stent migration and tumor ingrowth.
The Impact of Galectin-3 Inhibition on Aldosterone-Induced Cardiac and Renal Injuries
Authors: Laurent Calvier, Ernesto Martinez-Martinez, Maria Miana, Victoria Cachofeiro, Elodie Rousseau, J. Rafael Sádaba, Faiez Zannad, Patrick Rossignol, Natalia López-Andrés
Journal: JACC Heart Failure (2014)
Treating breast cancer conservatively: dissension, contention continue
Authors: J. Kohn
Journal: JAMA (1982)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Genotypic and phenotypic analysis of variants resistant to hepatitis C virus nonstructural protein 5A replication complex inhibitor BMS-790052 in Humans: In Vitro and In Vivo Correlations
Authors: Robert A. Fridell, Chunfu Wang, Jin-Hua Sun, Donald R. O'Boyle, Peter Nower, Lourdes Valera, Dike Qiu, Susan Roberts, Xin Huang, Bernadette Kienzle, Marc Bifano, Richard E. Nettles, Min Gao
Journal: Hepatology (2010)

Abstract The NS5A replication complex inhibitor, BMS-790052, inhibits hepatitis C virus (HCV) replication with picomolar potency in preclinical assays. This potency translated in vivo to a substantial antiviral effect in a single-ascending dose study and a 14-day multiple-ascending dose (MAD) monotherapy study. However, HCV RNA remained detectable in genotype 1a–infected patients at the end of the MAD study. In contrast, viral breakthrough was observed less often in patients infected with genotype 1b, and, in several patients, HCV RNA declined and remained below the level of quantitation (&lt;25 IU/mL) through the duration of treatment. Here, we report on the results of the genotypic and phenotypic analyses of resistant variants in 24 genotype 1–infected patients who received BMS-790052 (1, 10, 30, 60, and 100 mg, once-daily or 30 mg twice-daily) in the 14-day MAD study. Sequence analysis was performed on viral complementary DNA isolated from serum specimens collected at baseline and days 1 (4, 8, and 12 hours), 2, 4, 7, and 14 postdosing. Analyses of the sequence variants (1) established a correlation between resistant variants emerging in vivo with BMS-790052 treatment and those observed in the in vitro replicon system (major substitutions at residues 28, 30, 31, and 93 for genotype 1a and residues 31 and 93 for genotype 1b); (2) determined the prevalence of variants at baseline and the emergence of resistance at different times during dosing; and (3) revealed the resistance profile and replicative ability (i.e., fitness) of the variants. Conclusion: Although resistance emerged during monotherapy with BMS-790052, the substantial anti-HCV effect of this compound makes it an excellent candidate for effective combination therapy. (Hepatology 2011)
AN ABSOLUTE METHOD FOR ASSAY OF VIRUS HEMAGGLUTININS
Authors: Seymour Levine, Theodore T. Puck, Bernard P. Sagik
Journal: The Journal of Experimental Medicine (1953)

A rapid and precise method is described for determination of absolute numbers of hemagglutinating particles present in virus suspensions. The method involves spectrophotometric measurement of the number of red cells dimerized by the virus under conditions in which formation of larger aggregates is precluded. Results of this procedure are compared with those of titrations based on egg infectivity and the polystyrene microsphere electron micrography for influenza virus; and with plaque count titrations on chick embryo cell monolayers in the case of the virus of Newcastle disease. The agreement is well within the limits expected in view of the different quantities which the various procedures measure. The conversion factor for transforming titre in hemagglutinating units based on the pattern procedure into absolute number of agglutinating particles is the same for influenza and Newcastle disease virus. The precipitation of red blood cells by Newcastle disease virus at 23 degrees C. is optimal at pH's between 6.2 and 5.8.
1170-143 Diltiazem attenuates the coronary vasodilatory response to adenosine and reduces the regional myocardial blood flow disparity and sestamibi defect magnitude in dogs with critical coronary stenoses
Authors: Kengo Hatada, Mirta Ruiz, Denny D Watson, George A Beller, David K Glover
Journal: Journal of the American College of Cardiology (2004)
Reduced-intensity conditioning therapy with busulfan, fludarabine, and antithymocyte globulin for HLA-haploidentical hematopoietic cell transplantation in acute leukemia and myelodysplastic syndrome
Authors: Kyoo-Hyung Lee, Je-Hwan Lee, Jung-Hee Lee, Dae-Young Kim, Miee Seol, Young-Shin Lee, Young-Ah Kang, Mijin Jeon, Hyun-Ju Hwang, Ah-Rang Jung, Sung-Han Kim, Sung-Cheol Yun, Ho-Jin Shin
Journal: Blood (2011)
Seasonality, but not prevalence of sudden infant death syndrome varies by region in mainland Britain
Authors: AS Douglas, PJ Helms, IT Jolliffe
Journal: European Respiratory Journal (1999)

This study aimed to investigate whether seasonal variation in day length contributed to winter/summer variation in sudden infant death syndrome (SIDS) at different latitudes in mainland Britain. Over 11 yrs 13,973 deaths were studied. Using appropriate analytic techniques a sine curve was fitted to monthly rates with the amplitude indicating magnitude of seasonal change. The rate of SIDS per 1,000 live births was the same (1.73) in the north as in the south. The amplitude was a quarter less in the north (41.3%) than in the south (54.2%) (p&lt;0.001). While annual rates did not differ, the within year distribution did. The findings for seasonality of SIDS births were similar (amplitudes: north 213%, south 32.3%). Correlations were made between SIDS amplitude and individual environmental factors, particularly temperature and day length. These complex issues, while reported briefly, do not allow firm conclusions. In the north the winter day length is shorter, sunshine hours are less and temperature is lower, but the winter increment in SIDS is less. The extent of seasonal variation of sudden infant death syndrome is greater in the south as compared with the colder, darker north but this has no effect on sudden infant death syndrome rates. Changing photoperiod by latitude, amongst other environmental influences, may hold clues to the aetiology of sudden infant death syndrome.
Nobel Laureates Enlighten a Collegiate Town
Authors: Janet Torpy
Journal: JAMA (2001)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal