tbuckley/cabot-search huggingface dataset:
A Cover Without Art
Authors: Lawrence A. Hill
Journal: JAMA (1996)

<h3>To the Editor.</h3> —"A Cover Without Art"<sup>1</sup>was an extremely effective way to make a point. However, we should keep in mind that artists all over the world have been and will continue to be victims of many other conditions besides the acquired immunodeficiency syndrome (AIDS). The point that premature death robs our world of artistic talent could have been made just as appropriately in any issue of<i>JAMA</i>dedicated to a disease that causes early death or loss of function. I would hope that the review by Dr Southgate would not divert attention from this fact. Yet I felt that her lack of acknowledgment of this reality and her dramatic singling out of some unique association of art with a disease were evidence of a loss of objectivity and undue politicization. I was likewise disappointed that<i>JAMA</i>was participating in the creation of what seems to be an emerging
Factors affecting the binding of urate to plasma proteins.
Authors: R Bluestone, I Kippen, J R Klinenberg, W M Whitehouse
Journal: Annals of the Rheumatic Diseases (1970)

Between the years 1958 and 1967, a series of 354 gouty patients was examined and investigated by one or both of the authors at one of three London hospitals: Hammer- smith, Charing Cross, and West London.The information for the survey was abstracted from the case records and rscorded on a proforma which permitted 100 items of data to be assembled for each patient.These were then fed into a computer which cross-referenced each of these items with all the others, enabling the incidence of one feature in relation to any other feature to be readily assessed.The 5,000 items of information so obtained have been scrutinized and form the basis of this survey.The data confirm what is already well-established knowledge concerning gout, such as the distribution of age at onset, the incidence of individual joint involvement, the comparatively high incidence of obesity, regular intake of alcohol, hypertension, proteinuria, and renal impairment, and the preponderance of gouty patients in the higher social classes.A number of interesting and hitherto unrecorded facts came to light concerning the relationship between hypertension, renal failure, age at onset, and duration of disease.
Diagnostic, treatment, and demographic factors influencing survival in a population-based study of adult glioma patients in the San Francisco Bay Area1
Authors: Margaret Wrensch, Terri Rice, Rei Miike, Alex McMillan, Kathleen R. Lamborn, Kenneth Aldape, Michael D. Prados
Journal: Neuro-Oncology (2006)

We compare survival estimates for population-based glioma cases by using two diagnostic coding schemes, (1) the International Classification of Diseases, Oncology, second edition (ICD-O-2) as reported by the Surveillance, Epidemiology, and End Results (SEER) program and (2) central neuropathology review diagnosis based on the World Health Organization II classification. In addition, among review categories, we estimate survival in relation to several patient demographic and treatment factors. Eligible cases included adults residing in the San Francisco Bay SEER Area with newly diagnosed, histologically confirmed glioma during the years 1991-1994 and 1997-1999. The study group included participating subjects for whom subsequent central neuropathology review confirmed glioma. We determined treatments, vital status, and other factors by using registry, interview, medical record, and active follow-up data. Survival differences between anaplastic astrocytoma (AA) and astrocytoma were apparent from review diagnoses (median months of survival for AA, 13.0 [95% CI, 9.9-19.5], and astrocytoma, 101.3 [95% CI lower limit, 42.1; upper limit not yet reached]), but not with ICD-O-2 diagnoses reported by SEER (median months of survival for AA, 16.6 [95% CI, 12.0-20.7], and astrocytoma, not otherwise specified, 17.2 [95% CI, 10.6-71.6]). This finding emphasizes the need for improvements in coding for nonglioblastoma astrocytomas to provide better population survival estimates. When review diagnosis was used, younger age and resection (vs. biopsy) were statistically significant for all histology groups analyzed by multivariable Cox proportional hazard models. Additional statistically significant variables were as follows: among 517 glioblastoma patients, radiation treatment and being married; among 105 AA patients, inclusion of chemotherapy in the initial treatment; and among 106 patients with nonanaplastic oligodendroglial tumors, college education. Further consideration of impact of marital status, education, and other social factors in glioma survival may be warranted.
Asymptomatic Peripheral Arterial Disease Is Independently Associated With Impaired Lower Extremity Functioning
Authors: Mary McGrae McDermott, Linda Fried, Eleanor Simonsick, Shari Ling, Jack M. Guralnik
Journal: Circulation (2000)

Background —We report the implications of asymptomatic lower extremity peripheral arterial disease (PAD) for lower extremity functioning among participants in the Women’s Health and Aging Study, an observational study of disabled women ≥65 years of age living in and around Baltimore. Methods and Results —The ankle brachial index (ABI) and measures of upper and lower extremity functioning were measured among study participants. Of 933 women with ABI ≤1.50, 328 (35%) had an ABI &lt;0.90, consistent with PAD. Sixty-three percent of PAD participants had no exertional leg pain. Among participants without exertional leg pain, lower ABI levels were associated with slower walking velocity, poorer standing balance score, slower time to arise 5 times consecutively from a seated position, and fewer blocks walked per week, adjusting for age, sex, race, cigarette smoking, and comorbidities. ABI was not associated independently with measures of upper extremity functioning. Conclusions —Asymptomatic PAD is common and is independently associated with impaired lower extremity functioning. In addition to preventing cardiovascular morbidity and death, further study is warranted to identify effective interventions to improve functioning among the growing number of men and women with asymptomatic PAD.
Carbon Ion Radiotherapy for Stage I Non-small Cell Lung Cancer Using a Regimen of Four Fractions during 1 Week
Authors: Tadaaki Miyamoto, Masayuki Baba, Toshio Sugane, Mio Nakajima, Tomoyasu Yashiro, Kennji Kagei, Naoki Hirasawa, Toshiyuki Sugawara, Naoyoshi Yamamoto, Masashi Koto, Hidefumi Ezawa, Kennoshuke Kadono, Hirohiko Tsujii, Jun-etsu Mizoe, Kyosan Yoshikawa, Susumu Kandatsu, Takehiko Fujisawa
Journal: Journal of Thoracic Oncology (2007)
Stimulation of surface IgM of chronic lymphocytic leukemia cells induces an unfolded protein response dependent on BTK and SYK
Authors: Sergey Krysov, Andrew J. Steele, Vania Coelho, Adam Linley, Marina Sanchez Hidalgo, Matthew Carter, Kathleen N. Potter, Benjamin Kennedy, Andrew S. Duncombe, Margaret Ashton-Key, Francesco Forconi, Freda K. Stevenson, Graham Packham
Journal: Blood (2014)
Ivabradine has no Effect on Cardiac Arrhythmias Observed During Dobutamine Infusion: A Comparative Study with β Blocker Therapy
Authors: Yüksel Çavuşoğlu, Kadir Uğur Mert, Aydın Nadir, Fezan Mutlu, Bektas Morrad, Taner Ulus
Journal: Journal of the American College of Cardiology (2013)
Induction of Aggressive Breast Cancer in p53 Wild Type Cells by BRCA1-IRIS Overexpression.
Authors: W. ElShamy
Journal: Cancer Research (2009)

Abstract Background: Agents that introduce genotoxic stresses in mammalian cells, such as paclitaxel (Taxol) or ionizing radiation activate a complex array of cellular responses, including p53 activation. As a component of the response to acute stress, p53 has a well-established role in protecting against cancer development. It is not surprising that half of all human tumors have mutated p53. We asked how then tumors are initiated in the cells that carry wild-type p53 allele?Material and Methods: Here we report the identification of a potential novel mechanism that induces tumor formation in p53 wild-type cells. Overexpression of the proto-oncogene, BRCA1-IRIS in human mammary epithelial (HME) cells not only upregulates the expression of the serine/threonine phosphatase; Wild-type p53-Induced Phosphatase (WIP1) through induction of p53 expression but also increases the WIP1 gene copy number in these cells. WIP1 is a negative regulator of p53 as well as p38MAPK. Both proteins are involved in arresting and/or killing cells with extensive genotoxic stresses. Failure to arrest or die in response to massive genotoxic stress leads to the propagation of damaged cells and the development of cancer. BRCA1-IRIS overexpressing cells failed to arrest or die when exposed to UV radiation or Taxol. In fact, treatment of normal HME cells with UV or Taxol upregulated the expression of BRCA1-IRIS and thus WIP-1, prevented p53 and p38MAPK activation and their death.Results: This data suggest that BRCA1-IRIS is perhaps involved in the acquisition of cellular resistance to these agents upon prolonged exposure. On the other hand, depletion of BRCA1-IRIS from tumor cell lines induced apoptosis even in cells with functional p53 and p38MAPK.Discussion: We propose that in p53 wild type cells, whether endogenous or UV- or chemotherapy-induced BRCA1-IRIS overexpression leads to the survival and proliferation of what most likely are severely damaged cells, leading to the transformation of mammary cells in vitro and the induction of breast tumors in vivo. We also propose that BRCA1-IRIS and WIP1 overexpression abrogates the homeostatic balance maintained by p38-p53-WIP1 pathway. Together with the ability of BRCA1-IRIS to upregulate Cyclin D1 expression increases the likelihood that BRCA1-IRIS is an oncogene that induces breast cancer progression when overexpressed, hence making it an attractive target for novel breast cancer therapy. Citation Information: Cancer Res 2009;69(24 Suppl):Abstract nr 3154.
German doctors face new liabilities
Authors: H. L Karcher
Journal: BMJ (1998)

The German federal constitution court (Bundesverfassungsgericht) has ruled that doctors could be liable if a child is born after an unsuccessful sterilisation operation or with deformities because of a false diagnosis in genetic counselling.

The ruling followed appeals by two doctors. One had performed a vasectomy on a patient who fathered a child in 1984. …
Invasive Enteropathic<i>Escherichia coli</i>Dysentery
Authors: Tulloch Ef, Ryan Kj, Formal Sb, Franklin Fa
Journal: Annals of Internal Medicine (1973)

Twenty-eight of 37 persons between the ages of 20 and 55 years developed acute dysentery in from 24 to 48 hours after eating contaminated, imported French Camembert cheese. An O124 Escherichia coli was isolated from the cheese and from the stools of nine ill individuals. Biological testing showed this organism to be invasive in character. The predominant symptoms were fever, malaise, tenesmus, abdominal cramping, and diarrhea. None of the patients required hospitalization or antibiotic therapy, and most were asymptomatic within 1 week. This epidemic was part of the first known outbreak of invasive E. coli dysentery in adults that occurred in the United States.
IOM Endorses Vitamin D, Calcium Only for Bone Health, Dispels Deficiency Claims
Authors: Anita Slomski
Journal: JAMA (2011)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Women consume far more of health budget than expected
Authors: C. Zinn
Journal: BMJ (1998)

Australia's first systematic analysis of the costs of disease and injury to the health system has shown that costs for women are a third higher than for men and that the greatest killers receive a smaller slice of the budget than less serious conditions.

The authors of the Australian Institute of Health and Welfare's report were surprised at the size of the differences--the average health costs for women aged over 75 were $A7900 (£2800; …
Spondyloarthropathies and IgA deficiency.
Authors: H G Taylor, P T Dawes
Journal: Annals of the Rheumatic Diseases (1991)

Letters to the editor with RA (three with corresponding clinical tenosynovitis).On the other hand, one of seven controls and eight of 15 patients with RA with a clinical tenosynovitis did not present this special isotopic picture.In the controls a false positive isotopic uptake was noted in 35% and a false negative in 3% of the joints when compared with joint pain.There was only low agreement between joint pain and the radiological score in patients with nodular osteoarthrosis (42%).For patients with RA the pain and swelling scores were in total agreement in 66% of the joints.These
THE PREVENTION OF SPINAL CORD DEGENERATION IN PERNICIOUS ANEMIA
Authors: PAUL STARR
Journal: JAMA (1931)

A survey of the clinical course of eight patients with pernicious anemia and spinal cord degeneration indicates that they may be divided sharply into a group of four that have shown no neurologic progress and a like number that have grown steadily worse. The period of observation in five of these cases is more than three years; the others have been followed from one and a half to two and a half years.  The determination of the effect of liver treatment on funicular myelosis in pernicious anemia is of the greatest importance. The hematopoietic remission with liver occurs so readily that it is probable that the majority of these anemic patients will be preserved by it from death in anemia. Yet, if cord degeneration is not preventable by the same means, over 80 per cent 1 of these might develop it with its prolonged disability, painful symptoms and ultimate death
The release of prostaglandin E2 from a novel crystalline-rubbery poly (ethylene oxide) network crosslinked by 3,4-dihydro-2H-pyranyl-2-methyl-(3,4-dihydro-2H-pyran-2-carboxylate)
Authors: N.B. Graham, M.E. McNeill, A. Rashid
Journal: Journal of Controlled Release (1985)
Erratum: Corrigendum: Ulcerative colitis-risk loci on chromosomes 1p36 and 12q15 found by genome-wide association study
Authors: Mark S Silverberg, Judy H Cho, John D Rioux, Dermot P B McGovern, Jing Wu, Vito Annese, Jean-Paul Achkar, Philippe Goyette, Regan Scott, Wei Xu, M Michael Barmada, Lambertus Klei, Mark J Daly, Clara Abraham, Theodore M Bayless, Fabrizio Bossa, Anne M Griffiths, Andrew F Ippoliti, Raymond G Lahaie, Anna Latiano, Pierre Paré, Deborah D Proctor, Miguel D Regueiro, A Hillary Steinhart, Stephan R Targan, L Philip Schumm, Emily O Kistner, Annette T Lee, Peter K Gregersen, Jerome I Rotter, Steven R Brant, Kent D Taylor, Kathryn Roeder, Richard H Duerr
Journal: Nature Genetics (2009)
CXCR3-mediated chemotaxis of human T cells is regulated by a Gi- and phospholipase C–dependent pathway and not via activation of MEK/p44/p42 MAPK nor Akt/PI-3 kinase
Authors: Martine J. Smit, Pauline Verdijk, Elisabeth M. H. van der Raaij-Helmer, Marjon Navis, Paul J. Hensbergen, Rob Leurs, Cornelis P. Tensen
Journal: Blood (2003)
Loss of the ex vivo but not the reinducible CD8+ T-cell response to Tax in human T-cell leukemia virus type 1-infected patients with adult T-cell leukemia/lymphoma
Authors: B Arnulf, M Thorel, Y Poirot, R Tamouza, E Boulanger, A Jaccard, E Oksenhendler, O Hermine, C Pique
Journal: Leukemia (2003)
A Portfolio of Chest Radiographs for Undergraduate and Postgraduate Students
Authors: Richard E. Buenger
Journal: JAMA (1964)

This collection of technically fine radiographs of interesting disease processes is arranged in logical anatomico-pathological divisions. Each section is preceded by a rather incomplete, short, elementary text of etiological, radiographic, clinical, and therapeutic features. Presentation of the radiographic material is in serial form, providing a rare opportunity to observe the progression and regression of diseases of the chest. Instead of illustrating exotic chest diseases, the book presents common conditions and compares the varied radiographic and clinical manifestations of each disease in detail, emphasizing basic radiographic and surgical principles. The detailed legends accompanying each set of radiographs are in general far too verbose, but many gems of surgical and radiographic diagnosis appear suddenly in these descriptions. Titles are absent from the illustrations, precluding a rapid survey of the material. A variation in degree of magnification as well as in actual size of the prints and an unattractive black masking of the
IL7 signaling confers polyfunctionality to antitumor CD4+ T cells
Authors: Gang Zhou, Zhi-Chun Ding
Journal: Journal for ImmunoTherapy of Cancer (2014)

Meeting abstracts Mounting evidence indicates that polyfunctional T cells, effector T cells capable of simultaneously producing multiple pro-inflammatory cytokines, are more efficacious in controlling infection and cancer. Our previous study reported that adoptive transfer of tumor-specific CD4+ T
Building the Patient-Centered Medical Home in Ontario
Authors: Richard H. Glazier
Journal: JAMA (2010)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Immunological associations of the halo naevus with cutaneous malignant melanoma*
Authors: P.W.M. COPEMAN, M.G. LEWIS, T.M. PHILLIPS, P.G. ELLIOTT
Journal: British Journal of Dermatology (2006)

Journal Article Immunological associations of the halo naevus with cutaneous malignant melanoma Get access P.W.M. COPEMAN, P.W.M. COPEMAN Westminster Hospital, London, S.W.I Requests for reprints; Dr P.W.M.Copeman, Department of Dermatology, Westminster Hospital, London, S.W.I. Search for other works by this author on: Oxford Academic Google Scholar M.G. LEWIS, M.G. LEWIS Westminster Hospital, London, S.W.I Search for other works by this author on: Oxford Academic Google Scholar T.M. PHILLIPS, T.M. PHILLIPS Westminster Hospital, London, S.W.I Search for other works by this author on: Oxford Academic Google Scholar P.G. ELLIOTT P.G. ELLIOTT Westminster Hospital, London, S.W.I Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 88, Issue 2, 1 February 1973, Pages 127–137, https://doi.org/10.1111/j.1365-2133.1973.tb07517.x Published: 01 February 1973 Article history Accepted: 18 July 1972 Published: 01 February 1973
Diabetes Care in Extended-Care Facilities
Authors: Rachel M. Holt, Frank L. Schwartz, Jay H. Shubrook
Journal: Diabetes Care (2007)

OBJECTIVE—The American Diabetes Association (ADA) does not recognize different treatment goals for the institutionalized adult compared with the outpatient adult with diabetes, nor has it outlined specific recommendations for this population. The purpose of this study was to examine physician management of patients with type 1 and type 2 diabetes residing in extended-care facilities and to compare this management with ADA standards of care for the outpatient adult. RESEARCH DESIGN AND METHODS—This retrospective chart review included data from 108 residents with type 1 or type 2 diabetes at 11 extended health care facilities in the Midwestern U.S. and included a review of the medical problem list, medication list, laboratory reports, and all physician and consultation notes during the study period. RESULTS—Blood glucose was monitored in 98% of the subjects, and 38% met glucose goals. A1C goal was achieved in 67% of patients. Blood pressure was monitored in 94% of patients, with 55% meeting goal. Thirty-one percent of patients had yearly lipids checked, 37% had annual electrocardiograms, 7% had urine analyzed for microalbuminuria, 42% were on aspirin, 87% received foot exams, 42% received dilated eye exams, 89% received influenza vaccinations, and 46% received pneumoccocal vaccinations. CONCLUSIONS—Care of the institutionalized elderly with diabetes fails to meet ADA standards of care for the outpatient adult. Separate practice guidelines are needed for people with diabetes who reside in extended care facilities in order to improve quality and consistency of care.
Defective lymphopoiesis in the bone marrow of motheaten (me/me) and viable motheaten (mev/mev) mutant mice. III. Normal mouse bone marrow cells enable mev/mev prothymocytes to generate thymocytes after intravenous transfer.
Authors: K L Komschlies, D L Greiner, L Shultz, I Goldschneider
Journal: The Journal of Experimental Medicine (1987)

Bone marrow prothymocytes from me/me and mev/mev mutant mice fail to generate thymocytes in irradiated (600 rad) +/+ wild-type recipients after intravenous injection. However, these same prothymocytes readily generate thymocytes after intrathymic injection. The results of the present study demonstrate that this apparent defect in the thymus-homing capacity of mev/mev prothymocytes can be corrected by mixing irradiated wild-type bone marrow cells with mev/mev bone marrow cells before intravenous injection. However, this defect is not corrected by passage of mev/mev bone marrow cells through the bone marrow of irradiated wild-type recipients. One interpretation of these results is that the maturation of prothymocytes is reversibly arrested in mev/mev mice by a defect in the radiosensitive compartment of the bone marrow microenvironment.