CARONAMIDE AND PENICILLIN IN SUBACUTE BACTERIAL ENDOCARDITIS DUE TO STREPTOCOCCUS FAECALIS
Authors: W G LEAMAN, M B WIKINGSSON
Journal: Annals of Internal Medicine (1949)

Case Reports1 March 1949CARONAMIDE AND PENICILLIN IN SUBACUTE BACTERIAL ENDOCARDITIS DUE TO STREPTOCOCCUS FAECALISWILLIAM G. LEAMAN, M.D., F.A.C.P., MARIAN B. WIKINGSSON, M.D., MARIE B. WEBSTER, M.D., CHRISTOPHER C. SHAW, M.D., F.A.C.P.WILLIAM G. LEAMAN, M.D., F.A.C.P.Search for more papers by this author, MARIAN B. WIKINGSSON, M.D.Search for more papers by this author, MARIE B. WEBSTER, M.D.Search for more papers by this author, CHRISTOPHER C. SHAW, M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-30-3-646 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptPenicillin is the antibiotic of choice in the treatment of subacute bacterial endocarditis1 if the organism is sensitive to the bactericidal action of penicillin.Adequate daily dosage of penicillin over a sufficiently long period is imperative in obtaining clinical success with antibiotic therapy.2Insufficient amounts of penicillin may produce a deceptive response, with disappearance of symptoms, drop in temperature and sterile blood cultures, but as soon as such inadequate treatment is discontinued bacteremia promptly returns.3Another danger inherent in sub-curative therapy is the development of resistance to the antibiotic by the pathogenic organism. Subsequent therapy may require extremely large daily...Bibliography1. DAWSONHUNTER NHTH: The treatment of subacute bacterial endocarditis with penicillin; results in 20 cases, Jr. Am. Med. Assoc., 1945, cxxvii, 129. Idem: The treatment of subacute bacterial endocarditis with penicillin; second report, Ann. Int. Med., 1946, xxiv, 170. CrossrefGoogle Scholar2. BLOOMFIELDARMSTRONGKIRBY ALCDWM: The treatment of subacute bacterial endocarditis with penicillin, Jr. Clin. Invest., 1945, xxiv, 251. CrossrefGoogle Scholar3. BLOOMFIELDHALPERN ALRM: The penicillin treatment of subacute bacterial endocarditis, Jr. Am. Med. Assoc., 1945, cxxix, 1135. CrossrefGoogle Scholar4. MEADSHARRISFINLAND MWHM: The treatment of bacterial endocarditis with penicillin, New Eng. Jr. Med., 1945, ccxxxii, 463. CrossrefGoogle Scholar5. PRIESTSMITHMCGEE WSJMCJ: Penicillin therapy of subacute bacterial endocarditis: A study of the end results in 34 cases, with particular reference to dosage, methods of administration, criteria for judging adequacy of treatment and probable reasons for failures, Arch. Int. Med., 1947, lxxix, 333. CrossrefGoogle Scholar6. LOEWEALTURE-WERBER LE: Clinical manifestations of subacute bacterial endocarditis caused by streptococcus S.B.E., Am. Jr. Med., 1946, i, 353. CrossrefGoogle Scholar7. HUNTER TH: Treatment of subacute bacterial endocarditis with antibiotics (Seminar on the therapeutic use of antibiotics), Am. Jr. Med., 1946, i, 83. CrossrefGoogle Scholar8. GEIGER AJ: Experiences in the treatment of subacute bacterial endocarditis with penicillin, Am. Heart Jr., 1947, xxxiii, 736. (Summary.) Google Scholar9. LOEWE L: Combined use of penicillin and heparin in treatment of subacute bacterial endocarditis, Canad. Med. Assoc. Jr., 1945, lii, 1. Google Scholar10. PRIESTSMITHMCGEE WSJMCJ: Effect of anticoagulants on penicillin therapy and pathologic lesion of subacute bacterial endocarditis, New Eng. Jr. Med., 1946, ccxxxv, 699. CrossrefGoogle Scholar11. GROLNICKLOEWE ML: Immunologic studies in patients with subacute bacterial endocarditis treated by combined penicillin heparin method; Report of sensitivity to heparin in patient, Am. Jr. Allergy, 1947, xviii, 277. CrossrefGoogle Scholar12. ROMO FJ: Penicillin in the treatment of subacute bacterial endocarditis: Studies in 21 patients, Am. Heart Jr., 1947, xxxiii, 736. (Summary.) Google Scholar13. RAMMELKAMPBRADLEY CHSW: Excretion of penicillin in man, Proc. Soc. Exper. Biol. and Med., 1945, liii, 30. Google Scholar14. LOEWEROSENBLATTALTURE-WERBER LPE: A refractory case of subacute bacterial endocarditis due to Veillonella Gazogenes, clinically arrested by a combination of penicillin, sodium para-aminohippurate and heparin, Am. Heart Jr., 1946, xxxii, 327. CrossrefGoogle Scholar15. BRONFENBRENNERFAVOUR JCB: Increasing and prolonging blood penicillin concentrations following intramuscular administration, Science, 1945, ci, 673. CrossrefGoogle Scholar16. MOKOTOFFBRAMSKATZHOWELL RWLNKM: The treatment of bacterial endocarditis with penicillin. Results of 17 consecutive unselected cases, Am. Jr. Med. Sci., 1946, ccxi, 395. CrossrefGoogle Scholar17. AVERYMAYERNELSON NLOBRC: Massive doses of penicillin in the treatment of subacute bacterial endocarditis, Ann. Int. Med., 1946, xxiv, 900. Google Scholar18. BOGERBAKER WPRM: A comparison of the effect of caronamide and benzoic acid on penicillin plasma concentrations, Proc. Soc. Exper. Biol. and Med. (in press). Google Scholar19. BEYER KH: New concept of competitive inhibition of the renal tubular excretion of penicillin, Science, 1947, cv, 94. CrossrefGoogle Scholar20. RAKERICHARDSON GAP: Pharmacology of penicillin, Ann. New York Acad. Sci., 1946, xlviii, 143. CrossrefGoogle Scholar21. CROSSONBOGERSHAWMILLER JWWPCCAK: Caronamide for increasing penicillin plasma concentrations in man, Jr. Am. Med. Assoc., 1947, cxxxiv, 1528. CrossrefGoogle Scholar22. BEYERMILLERRUSSOPATCHVERWEY KHAKHFEAWF: The inhibitory effect of caronamide on the renal elimination of penicillin, Am. Jr. Physiol., 1947, cxlix, 355. CrossrefGoogle Scholar23. BEYERRUSSOPATCHTILLSONSHANER KHHFEAEKG: Certain pharmacologic properties of 4'-carboxyphenylmethanesulfonanilide (caronamide), including its effect on the renal clearance of compounds other than penicillin, Jr. Pharm. and Exper. Therap., 1947, xci, 272. Google Scholar24. SHAWBOGERCROSSONKEMPLINGDUNCAN CCWPJWWWWSGG: Enhancement of penicillin blood levels in man by means of a new compound, caronamide, Am. Jr. Med., 1947, iii, 206. CrossrefGoogle Scholar25. BEYERMCKINNEYTILLSONGREEN KHSEEKCW: 4'-carboxyphenylmethanesulfonanilide (caronamide): Its toxicologic effects, Jr. Pharm. and Exper. Therap., 1947, xci, 263. Google Scholar26. SEELERWILCOXFINLAND AOCM: Enhancement of blood levels by caronamide during intramuscular administration of penicillin, Jr. Lab. and Clin. Med., 1947, xxxii, 807. Google Scholar27. BOGERKAYEISMANYEOMAN WPCFSHEE: Caronamide, a compound that inhibits penicillin excretion by the renal tubules, applied to the treatment of subacute bacterial endocarditis, Am. Jr. Med. Sci., 1947, ccxiv, 493. CrossrefGoogle Scholar28. ZIEGLERSPRAGUE CJM: A colorimetric determination of caronamide, Jr. Lab. and Clin. Med., 1948, xxxiii, 96. Google Scholar29. BOGERMILLERTILLSONSHANER WPAKEKGA: Caronamide: Plasma concentrations, urinary recoveries and dosage, Jr. Lab. and Clin. Med., 1948, xxxiii, 297. Google Scholar30. EISMANKAYMORRISBOGER SHCFRFWP: Caronamide as an adjuvant to penicillin in the treatment of subacute bacterial endocarditis, Am. Jr. Med. Sci., 1949, ccxvii, 62. CrossrefGoogle Scholar31. ZELLERLEPPERROBINSONHIRSHDOWLING WWMHJAHLHF: The effect of caronamide on the blood concentration of penicillin following oral and intramuscular administration of penicillin, Ann. Int. Med., 1949, xxx, 398-407. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Washington, D. C.*Staticin' caronamide was supplied through the courtesy of Sharp & Dohme, Inc., Philadelphia, Pa.†Received for publication December 11, 1947.From the Department of Medicine, The Hospital of the Woman's Medical College of Pennsylvania, Philadelphia, Pa.‡Resident in Medicine, University Hospital, Madison, Wis.§Captain (MC) U S N, on active duty at Research Division. Bureau of Medicine and Surgery, Navy Department. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byAntibiotic prophylaxis against infective endocarditis after normal delivery--is it necessary?Erkrankungen des EndokardTreatment of Bacterial EndocarditisProgress in Bacterial EndocarditisENTEROCOCCAL ENDOCARDITIS: REPORT OF A CASE TREATED WITH AUREOMYCIN*JAMES F. FLANDERS, M.D., LEMUEL C. MCGEE, M.D., F.A.C.P., E. G. SCOTTDie Therapie der Endocarditis lenta und ihre GrundlagenStreptomycin in the Treatment of Subacute Bacterial Endocarditis 1 March 1949Volume 30, Issue 3Page: 646-654KeywordsAntibiotic resistanceBacteremiaBloodEndocarditisHospital medicinePathogensPenicillinStreptococcusSurgeryTemperature ePublished: 1 December 2008 Issue Published: 1 March 1949 PDF downloadLoading ...