ARLIDIN: A CLINICAL EVALUATION OF A PERIPHERAL VASODILATOR WITH SELECTIVE ACTION ON MUSCLE VESSELS
Authors: I D STEIN
Journal: Annals of Internal Medicine (1956)

Article1 August 1956ARLIDIN: A CLINICAL EVALUATION OF A PERIPHERAL VASODILATOR WITH SELECTIVE ACTION ON MUSCLE VESSELSIRWIN D. STEIN, M.D., F.A.C.P.IRWIN D. STEIN, M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-45-2-185 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptA pressing need in the management of the chronic occlusive arterial diseases is an effective oral vasodilator to control the common presenting complaint of intermittent claudication. Many drugs and procedures have been tried but found wanting, some because of undesirable side-effects and difficulty in administration, others because they improved circulation in skin areas and did little to relieve muscle ischemia.Some years ago, while investigating the effects of the intra-arterial injection of adrenalin upon blood flow in the forearm,1we were struck by the marked dilation it produced in muscle even in minute concentration. These doses proved to be constrictor,...Bibliography1. HarpuderByerStein KJID: Effect of intra-arterial injection of adrenalin upon blood flow in the human forearm, Am. J. Physiol. 150: 181, 1947. CrossrefMedlineGoogle Scholar2. KulzSchneider FM: New sympathomimetic vasodilators, Klin. Wchnschr. 28: 535, 1950. MedlineGoogle Scholar3. Wiemers K: Vasodilators of the adrenalin-benzedrine series, Arch. f. exper. Path. u. Pharmakol. 213: 283, 1951; 213: 314, 1951; 213: 335, 1951. CrossrefGoogle Scholar4. Freedman L: Arlidin—a new vasodilative sympathomimetic drug, Angiology 6: 52, 1955. CrossrefMedlineGoogle Scholar5. HenselRuefGelenhofen FJK: The effect of vasoactive substances upon muscle and skin blood flow, Ztschr. f. Kreislaufforsch. 43: 756, 1954. MedlineGoogle Scholar6. RiddellSteelMcCoy MBMJM: Studies with Dilatol, a vasodilator substance, Angiology 5: 314, 1954. CrossrefMedlineGoogle Scholar7. PomeranzeGadekPitmanScherl JRJERS: Therapy in intermittent claudication, Angiology 6: 271, 1955. CrossrefMedlineGoogle Scholar8. Abramson DI: Vascular responses in the extremities of man, 1944, University of Chicago Press, Chicago. Google Scholar9. SteinHarpuderByer IDKJ: Reactivity of blood vessels in the sympathectomized human leg, Am. J. Physiol. 158: 319, 1949. CrossrefMedlineGoogle Scholar10. Stein ID: A comparative study of peripheral vasodilating drugs, to be published. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Mount Vernon, N. Y.*Received for publication January 27, 1956.Requests for reprints should be addressed to Irwin D. Stein, M.D., 117 S. Second Ave., Mount Vernon, N. Y.†Generous supplies of Arlidin for clinical use were made available by the U. S. Vitamin Corporation. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byObservations on the performance of a standard exercise test by claudicants taking γ-linolenic acidThe Effects of Dichloroisoproterenol, Nylidrin, and Placebo on Peripheral Blood FlowTime-Concentration Curves Over Calf and Foot of I131-Labeled Human Serum Albumin (Risa) After Intra-Arterial InjectionEffect of Nylidrin Hydrochloride On the Skin and Muscle Temperatures of Patients With Occlusive Arterial Disease of the Lower ExtremitiesOCCULT MYOCARDIAL INSUFFICIENCY AND PERIPHERAL VASCULAR INSUFFICIENCY: A DIRECT RELATIONSHIPKrankheiten der GefäßeSome observations and questions on the medical management of intermittent claudication∗VASODILATING MEASURES IN THE TREATMENT OF PERIPHERAL VASCULAR DISEASE† 1 August 1956Volume 45, Issue 2Page: 185-190KeywordsAttentionBlood flowDrug administrationDrugsIschemiaMusclesVasodilators ePublished: 1 December 2008 Issue Published: 1 August 1956 PDF downloadLoading ...