tbuckley/cabot-search huggingface dataset:
A study of natural rubber latex allergens in gloves used by healthcare workers in Singapore
Authors: D. Koh, V. Ng, Y-H. Leow, C.L. Goh
Journal: British Journal of Dermatology (2005)

Background Allergy to natural rubber latex (NRL) proteins is a well‐recognized health problem among subjects using protective gloves and products made of NRL. There is currently no information on NRL allergen levels in gloves used in Singapore.
Formed visual hallucinations with pituitary adenomas.
Authors: D J Dawson, B A Enoch, D I Shepherd
Journal: BMJ (1984)

a case for safe non-steroidal anti-inflammatory or analgesic drugs being available over the counter, the medical profession should be aware of them.Doctors prescribe assuming that treatment will not be dupli- cated and that potential toxicity and inappropriate combinations of drugs will be avoided.No (°O) of correct answers from 93 questionnaires Recognised as being available over the Proprietary names Contents counter Contents known Triadol Benorylate 16 (17 2) 13 (14 0) Nurofen Ibuprofen 61 (65-6) 57 (61-2) Proflex Ibuprofen 26 (28-0) 6 (6-5) Maxagesic Ibuprofen 8 (8 6) 2 (2 2) Phensic Aspirin 93 (100) 66 (71 0) 1 \Weinberger LM, Grant FC.Visual hallucinations and their neuro-optical
Myeloid-derived suppressor cell function is diminished in aspirin-triggered allergic airway hyperresponsiveness in mice
Authors: Maohua Shi, Guochao Shi, Juan Tang, Deping Kong, Yao Bao, Bing Xiao, Caojian Zuo, Tai Wang, Qingsong Wang, Yujun Shen, Hui Wang, Colin D. Funk, Jie Zhou, Ying Yu
Journal: Journal of Allergy and Clinical Immunology (2014)
ILEI: A cytokine essential for EMT, tumor formation, and late events in metastasis in epithelial cells
Authors: Thomas Waerner, Memetcan Alacakaptan, Ido Tamir, Rupert Oberauer, Annamaria Gal, Thomas Brabletz, Martin Schreiber, Martin Jechlinger, Hartmut Beug
Journal: Cancer Cell (2006)
I am 50
Authors: R Wilkins
Journal: BMJ (1994)

I am 50. It sounds strange to my ears so let me repeat it. I am 50. I still cannot believe it. As someone once said, “I am too young to be old and too old to be young.” When I was in medical school we had lectures on how to educate our patients for retirement but none on how to cope with being 50. Although my passport confirms the diagnosis, there were certain symptoms which should have alerted me to the possibility of the inevitability of this incurable condition.

A few years ago I noticed that hair was growing in my ears. This may have been compensation for the hair not growing on my head. What hair I do have is growing white, which I maintain is due to the chlorine in the swimming pool. I have now been forced to buy bifocal lenses. I used to think that the British policeman looked like an 18 year old; now he looks 15. I have become interested in articles about the elderly, death, and dying rather than childbirth and changing nappies. They say that if anyone over 50 wakes up in the morning and does not have any pains anywhere he should check that he is alive.

I have started losing my memory in that I always carry two sets of car keys with me because I often leave one set in the …
Twelve-Year "Cure" of Lung Cancer With Metastasis to the Brain
Authors: William H. Mosberg
Journal: JAMA (1976)

In managing lung cancer with metastasis to the brain, the clinician must decide whether to treat the primary lesion, the metastasis, neither, or both. A patient enjoying a useful survival of five years or more following treatment may be regarded as apparently cured. This patient was functioning normally twelve years after surgical treatment of the brain and lung lesions. Lung cancer with metastasis to the brain is not always a hopeless situation; occasionally a patient will derive great benefit from treatment.
I. EFFECTS OF THE INTRAVENOUS INJECTION OF COLLOIDAL SILVER UPON THE HEMATOPOIETIC SYSTEM IN DOGS
Authors: Samuel S. Shouse, George H. Whipple
Journal: The Journal of Experimental Medicine (1931)

1. Colloidal silver has no specific action on the bone marrow in dogs but is a systemic poison which may cause anorexia, weakness, loss of weight, anemia, and death. 2. Hemolysis can be demonstrated after large doses of colloidal silver and the anemia presumably is due in part at least to a destruction of red blood cells in the peripheral circulation. 3. The colloidal silver, injected intravenously, is deposited as granules almost exclusively in the cells of the reticulo-endothelial system after the manner of particulate substances. 4. Repeated injections of non-lethal amounts of this substance are invariably followed by hyperplasia of the bone marrow. In no case was aplasia found. 5. Large single doses of this material cause rapid death in 12 hours or less characterized by pulmonary edema and congestion. 6. An initial increase in the number of erythrocytes and leucocytes may occur following smaller amounts of silver, but repeated injections cause a considerable anemia, without a definite increase in the leucocytes and with no signs of blood platelet deficiency.
Long-Term Metaproterenol Therapy in Asthmatic Children
Authors: Milan L. Brandon
Journal: JAMA (1976)

The bronchodilator efficacy and safety of metaproterenol sulfate were evaluated by double-blind crossover tests against placebo at three intervals during a 90-day treatment period in 50 asthmatic children. One group of 25 patients was continuously treated with metaproterenol syrup, and the other 25 with placebo syrup. Pulmonary function tests showed statistically significant improvements in forced expiratory volume, forced expiratory volume in one second, and peak expiratory flow rate after metaproterenol administration as compared with those measurements after treatment with placebo. Biweekly global evaluations of responses to metaproterenol administration were consistently more favorable than responses to placebo. Tachycardia and blood pressure changes after metaproterenol administration were consistent with the pharmacologic properties of beta-sympathomimetic stimulants. Side effects during metaproterenol treatment were minimal and laboratory data remained normal. (<i>JAMA</i>235:736-737, 1976)
Sister chromatid exchanges and micronuclei in peripheral lymphocytes of shoe factory workers exposed to solvents.
Authors: Marià Pitarque, Alexander Vaglenov, Maria Nosko, Sonya Pavlova, Vera Petkova, Ari Hirvonen, Amadeu Creus, Hannu Norppa, Ricard Marcos
Journal: Environmental Health Perspectives (2002)

We examined sister chromatid exchanges (SCEs) and micronuclei (MN; cytokinesis-block method) in cultured peripheral lymphocytes from 52 female workers of two shoe factories and from 36 unexposed age- and sex-matched referents. The factory workers showed an elevated level of urinary hippuric acid, a biomarker of toluene exposure, and workplace air contained high concentrations of various organic solvents such as toluene, gasoline, acetone, and (in one of the plants only) ethylacetate and methylenediphenyl diisocyanate. The shoe factory workers showed a statistically significant higher frequency of micronucleated binucleate lymphocytes in comparison with the referents. This finding agreed with three preliminary MN determinations (each comprising 27-32 shoe workers and 16-20 controls) performed in one of the plants 2-5 years earlier. The shoe factory workers also had a lower average level of blood hemoglobin than the referents. In contrast, no difference was found between the groups in SCE analysis. Smokers showed significantly higher mean frequencies of SCEs per cell and high frequency cells (HFC) than nonsmokers. Aging was associated with increased MN rates and reduced cell proliferation. Polymorphism of the glutathione S-transferase M1 gene (GSTM1) did not affect the individual level of SCEs; but in smoking shoe workers an effect of the occupational exposure on the frequency of micronucleated cells could be seen only in GSTM1 null subjects. The low prevalence of the glutathione S-transferase T1 (GSTT1) null genotype precluded the evaluation of the influence of GSTT1 polymorphism. Our results show that the shoe factory workers have experienced genotoxic exposure, which is manifest as an increase in the frequency of MN, but not of SCEs, in peripheral lymphocytes. The exposures responsible for the MN induction could not be identified with certainty, but exposure to benzene in gasoline and methylenediphenyl diisocyanate may explain some of the findings.
Changes in leucocyte migration after renal transplantation
Authors: M. G. M. Smith, A. L. W. F. Eddleston, J. A. Dominguez, D. B. Evans, M. Bewick, R. Williams
Journal: BMJ (1969)

The leucocyte migration test, an in-vitro measure of cellular immunity, has been used to follow the changes in cell-mediated hypersensitivity to kidney and histocompatibility antigens in three patients after renal transplantation. Inhibition of leucocyte migration, indicating strong sensitization to the antigens used, occurred in each patient, starting five to seven days after transplantation. Satisfactory renal function had not been established in any of the patients at this time. In one case inhibition of leucocyte migration persisted almost continuously until the 24th day and was associated with poor renal function proved histologically to be due to rejection. Treatment with increased dosage of prednisone was associated with a rapid reversion to normal of the migration index and improvement in renal function. Later, inhibition of migration occurred again, and shortly afterwards the graft ceased to function. In the other two cases the migration index became normal without alteration in immunosuppressive therapy and a satisfactory diuresis followed. It is suggested that this simple test should prove useful in the specific diagnosis of rejection and in control of immunosuppressive therapy.
Habitual Abortion Due to Insufficiency of Internal Cervical Os
Authors: J. K. Wilson
Journal: BMJ (1957)

have a shorter duration of stay if they are admitted to a mental hospital.To demonstrate the relationship between physique and examination results larger samples are needed, because correlations between physique and intellectual perform- ance are usually of a lower order than those between physique and the temperamental and other qualities involved in severe mental illness.In the article' to which Dr. Finlay refers only 19 Leeds students are reported who gained first- class honours, together with 14 who were " bad failures " academically.Even if real differences should later be estab- lished, there are again differences in manner of selection at the two universities to be considered.Whether or not the small band of brilliant Lf students is a phenornenon peculiar to Oxford it is difficult to say, but the following conclusion from the original Oxford report2 should not be forgotten: " Mesomorphs were most consistent in attaining a good level of performance with firstor second-class honours."-Iam, etc., Oxford.
PLASMA SUBSTITUTES
Authors: F. S. Robscheit-Robbins, L. L. Miller, E. L. Alling, G. H. Whipple
Journal: The Journal of Experimental Medicine (1946)

Hemoglobin and globin alone, supplemented, or modified in various ways are seriously considered as plasma substitutes. Human globin given to doubly depleted (anemic and hypoproteinemic) dogs by vein contributes to the production of new hemoglobin and plasma protein, but there is some toxicity and weight loss. Dog hemoglobin given intraperitoneally is better tolerated and somewhat more completely utilized with more blood proteins formed and less weight loss. Dog globin (tryptic digest) given by vein in anemic dogs is associated with a moderate production of new hemoglobin. Horse globin by mouth contributes to the formation of new hemoglobin in the standard anemic dog. Dog hemoglobin given intraperitoneally in protein fasting, non-anemic dogs is well utilized to maintain nitrogen and weight balance. A dl-isoleucine supplement fails to improve this utilization of hemoglobin for maintenance in the dog. A small supplement of dl-methionine greatly improves the utilization of dog hemoglobin for maintenance in the dog and further addition of isoleucine is without effect. The intermediary metabolism of dog hemoglobin is not yet worked out. Electrophoretic analyses (Table 6) suggest that globin appears in the peripheral circulation after intraperitoneal injections of hemoglobin.
Culture and development matter to understanding souls, no matter what our evolutionary design
Authors: Michel Ferrari
Journal: Behavioral and Brain Sciences (2006)

For Bering, appreciating that people are objects is a developmental accomplishment. Baldwin and Piaget agree. However, for Piaget, an immanent conception of the divine is more developed than a separate transcendent God. Culture also matters. In Plato's Phaedo , Socrates' belief in immortality was a reasoned conclusion – not “built in” – for reasons similar to those still held by modern scientists.
Acquired Bile Duct Blockage
Authors: RONALD J. ROSENBERG, QUAZI T. ISLAM, RICHARD P. SPENCER
Journal: Clinical Nuclear Medicine (2000)

A 70-year-old man had a 23-year history of gallstones, pancreatitis, and necrotizing cholangitis. Although a biliary stent had been placed, many hospital admissions were required. He was examined for epigastric pain, icterus, and fever. A hepatobiliary study revealed little drainage of radiotracer from the liver. A superior pole hepatic defect, revealed on delayed images, was responsible for entry of the hepatobiliary radiotracer. Drainage of the region revealed an intrahepatic abscess.
Vascular Effects of Cocoa Rich in Flavan-3-ols
Authors: C. Heiss
Journal: JAMA (2003)

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Tight glycaemic control by an automated algorithm with time-variant sampling in medical ICU patients
Authors: Christoph Pachler, Johannes Plank, Heinz Weinhandl, Ludovic J. Chassin, Malgorzata E. Wilinska, Roman Kulnik, Peter Kaufmann, Karl-Heinz Smolle, Ernst Pilger, Thomas R. Pieber, Martin Ellmerer, Roman Hovorka
Journal: Intensive Care Medicine (2008)
Percutaneous endoscopic gastrostomy tube replacement
Authors: J. Turner, J. Berrill, S. Dolwani, J. Green, G. Swift
Journal: Endoscopy (2010)

Percutaneous endoscopic gastrostomy (PEG) tube insertion allows provision of long-term enteral nutrition in patients with dysphagia or those not meeting their nutritional requirement. PEG replacement may be required in patients with significant tube degradation or injury. Single esophageal intubation is preferable, to minimize patient discomfort and reduce the procedural risks associated with upper gastrointestinal endoscopy. Previously described methods of PEG replacement include: passage of the thread through the PEG tube, which is held in place by the plastic introducer [1], and passage of the snare through the thread and then around the PEG tube [2]. However, these methods are either complex to perform or have the potential to lose the guide wire or internal bumper during withdrawal. We describe an easy and reliable method of PEG tube replacement.
Screening to prevent renal failure in insulin dependent diabetic patients: an economic evaluation
Authors: B. A Kiberd, K. K Jindal
Journal: BMJ (1995)

To examine the conditions necessary to make screening for microalbuminuria in patients with insulin dependent diabetes mellitus cost effective.This economic evaluation compared two strategies designed to prevent the development of end stage renal disease in patients with insulin dependent diabetes with disease for five years. Strategy A, screening for microalbuminuria as currently recommended, was compared with strategy B, a protocol in which patients were screened for hypertension and macroproteinuria.Patients identified in both strategies were treated with an angiotensin converting enzyme inhibitor.Computer simulation.Strategy costs and quality adjusted life years (QALYs).The model predicted that strategy A would produce an additional 0.00967 QALYs at a present value cost of $261.53 (1990 US$) per patient (or an incremental cost/QALY of $27,041.69) over strategy B. The incremental cost/QALY for strategy A over B was sensitive to several variables. If the positive predictive value of screening for microalbuminuria (impact of false label and unnecessary treatment) is < 0.72, the effect of treatment to delay progression from microalbuminuria to macroproteinuria is < 1.6 years, the cumulative incidence of diabetic nephropathy falls to < 20%, or > 64% of patients demonstrate hypertension at the onset of microalbuminuria, then the incremental costs/QALY will exceed $75,000.Whether microalbuminuria surveillance in this population is cost effective requires more information. Being aware of the costs, recommendation pitfalls, and gaps in our knowledge should help focus our efforts to provide cost effective care to this population.
Serial Evaluation of the SOFA Score to Predict Outcome in Critically Ill Patients
Authors: Flavio Lopes Ferreira
Journal: JAMA (2001)

Evaluation of trends in organ dysfunction in critically ill patients may help predict outcome.To determine the usefulness of repeated measurement the Sequential Organ Failure Assessment (SOFA) score for prediction of mortality in intensive care unit (ICU) patients.Prospective, observational cohort study conducted from April 1 to July 31, 1999.A 31-bed medicosurgical ICU at a university hospital in Belgium.Three hundred fifty-two consecutive patients (mean age, 59 years) admitted to the ICU for more than 24 hours for whom the SOFA score was calculated on admission and every 48 hours until discharge.Initial SOFA score (0-24), Delta-SOFA scores (differences between subsequent scores), and the highest and mean SOFA scores obtained during the ICU stay and their correlations with mortality.The initial, highest, and mean SOFA scores correlated well with mortality. Initial and highest scores of more than 11 or mean scores of more than 5 corresponded to mortality of more than 80%. The predictive value of the mean score was independent of the length of ICU stay. In univariate analysis, mean and highest SOFA scores had the strongest correlation with mortality, followed by Delta-SOFA and initial SOFA scores. The area under the receiver operating characteristic curve was largest for highest scores (0.90; SE, 0.02; P<.001 vs initial score). When analyzing trends in the SOFA score during the first 96 hours, regardless of the initial score, the mortality rate was at least 50% when the score increased, 27% to 35% when it remained unchanged, and less than 27% when it decreased. Differences in mortality were better predicted in the first 48 hours than in the subsequent 48 hours. There was no significant difference in the length of stay among these groups. Except for initial scores of more than 11 (mortality rate >90%), a decreasing score during the first 48 hours was associated with a mortality rate of less than 6%, while an unchanged or increasing score was associated with a mortality rate of 37% when the initial score was 2 to 7 and 60% when the initial score was 8 to 11.Sequential assessment of organ dysfunction during the first few days of ICU admission is a good indicator of prognosis. Both the mean and highest SOFA scores are particularly useful predictors of outcome. Independent of the initial score, an increase in SOFA score during the first 48 hours in the ICU predicts a mortality rate of at least 50%.
Aerobic and Anaerobic Bacteria in Diabetic Foot Ulcers
Authors: Thomas J. Louie, John G. Bartlett, Francis P. Tally, Sherwood L. Gorbach
Journal: Annals of Internal Medicine (1976)

Twenty diabetic foot ulcers were cultured using optimal microbiologic techniques. Anaerobic bacteria coexisted with the more commonly recognized aerobic bacteria in 18 specimens. There were a total of 116 isolates with an average of 5.8 species per specimen (3.2 aerobes and 2.6 anaerobes). The principal isolates were Bacteroides species (sp.) (17 strains), peptococci (16), Proteus sp. (11), enterococci (9), Staphylococcus aureus (7), clostridia (7), and Escherichia coli (6). When antimicrobial therapy is indicated the selection of agents should consider the likelihood of a complex aerobic-anaerobic flora.
The 18th United States-Japan Joint Hepatitis Panel Meeting
Authors: S M Lemon, K Nishioka, S Mishiro, L Johnson
Journal: Hepatology (1997)

The 18th United States-Japan Joint Hepatitis Panel reporter protein expressed when plasmids containing various 5NTR sequences were analyzed.These data suggest that Meeting was held November 16-18, 1996, near Nagasaki, Japan.As in other meetings held in recent years, most presenta-HCV RNAs might vary in terms of their intrinsic translational activity, and that this must be considered as a possible tions focused on hepatitis C virus (HCV) infections.However, a considerable amount of new information concerning the determinant of viral pathogenicity.Dr. Kunitada Shimotohno (Kyoto University) described the novel human GB virus C (GBV-C)/HGV flavivirus (''hepatitis G virus'') was also presented.Dr. Kusuya Nishioka (Viral replication of HCV in the human T-cell leukemia virus type I (HTLV-1)-infected, MT-2C human T lymphocyte cell line.Hepatitis Research Foundation of Japan), Chairman of the Japanese delegation, opened the meeting with a brief discus-These cells were shown to be permissive for replication of a genotype 1b inoculum over four cell-free viral passages.By sion of the role of hepatitis viruses as agents of emerging and re-emerging infectious diseases.He noted the existence of a 12 days' postinfection, the degree of genetic diversity of the primary inoculum had been reduced with a lesser number of small fraction of cases of viral hepatitis for which no viral etiology could yet be found.This implies the existence of at viral quasispecies present.The ''3X tail'' sequence identified previously by Dr. Shimotohno's group and by Dr. Rice's labo-least one, yet-to-be-discovered hepatitis virus.Dr. Nishioka also noted the increasing recognition of the role played by ratory at the 3 terminus of the viral RNA was present in the virus recovered from these cells.HCV in the causation of liver-specific morbidity and mortality, both in Asia and in the United States.His remarks were Dr. Joe Kim (Vertex Pharmaceuticals) described the recently solved x-ray structure of the complex formed by the followed by eight scientific sessions.NS3 protease domain of HCV and its NS4A cofactor.The