LYMPHOSARCOMA AND HODGKIN'S DISEASE: CLINICAL CHARACTERISTICS
Authors: Solomon Ginsburg
Journal: Annals of Internal Medicine (1936)

Article1 September 1936LYMPHOSARCOMA AND HODGKIN'S DISEASE: CLINICAL CHARACTERISTICSSOLOMON GINSBURG, M.D.SOLOMON GINSBURG, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-10-3-337 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptA comprehensive survey of the available data reveals the following outstanding clinical characteristics of Hodgkin's disease.1.Malignant and Protean Character of Hodgkin's Disease. Hodgkin's disease is a specific malignant disease which most frequently first manifests itself clinically by enlargement of the lymph glands and spleen accompanied by toxemia, anemia, wasting and cachexia. However, it is not confined to these lymphoid organs only. It is of historic interest to record that it was Hodgkin himself who was the first to make this observation, which has been repeatedly corroborated by numerous students of this disease. Indeed, more than half a century...References1. GOWERS WR: Hodgkin's disease, in Reynold's System of Medicine, 1879, v, 306-352. Google Scholar2. MULFINO F: Sulle Sindrome Addisoniane da Linfogranuloma Maligno, La Rif. Med., 1932, xlviii, 899-902; abst. in Endokrinol., 1933, xii, 225. Google Scholar3. PISSAREWA T: Lymphogranulomatosis (Paltauf-Sternberg) des Verdauungstraktes, Arch. f. klin. Chir., 1928, cxlix, 75-91. Google Scholar4. CHUTE R: Malignant lymphoma and the urinary tract, Jr. Am. Med. Assoc., 1931, xcvii, 969-971. CrossrefGoogle Scholar5. DRESSER R: Lymphogranulomatose der Knochen (Hodgkinsche Krankheit), Strahlenth., 1931, xli, 401-416. Google Scholar6. LIVINGSTON SK: Hodgkin's of the skeleton without glandular involvement, Jr. Bone and Joint Surg., 1935, xvii, 189-194. Google Scholar7. ASKANAZY M: Lymphogranuloma des Knochenmarks, Verhandl. d. deutsch. path. Gesellsch., 1921, xviii, 78-83. Google Scholar8. KRUMBHAAR EB: Hodgkin's disease of bone marrow and spleen without apparent involvement of lymph nodes, Am. Jr. Med. Sci., 1931, clxxxii, 764-769. Google Scholar9. DAVISON C: Personal communication. (See figure 1.) Google Scholar10. PETRUGNANI R: Lymphogranulomatose maligne primitive du sein, Ann. d'anat. path. méd.-chir., 1930, vii, 360-364. Google Scholar11. GINSBURG S: Hodgkin's disease with predominant localization in the nervous system, Arch. Int. Med., 1927, xxxix, 571-595. CrossrefGoogle Scholar12. EUGENIS C: Les manifestations cerebro-medullaires de l'adenie eosinophilique prurigene, 1929, Bosc Freres and Riou, Lyon. Google Scholar13. THIEMER P: Zur Kasuistik der isolierten Lymphogranulomatose des Magendarmtraktes, Deutsch. Ztschr. f. Chir., 1927, ccv, 404-409. CrossrefGoogle Scholar14. FAVRECROIZATGUICHARD MPA: Étude anatomique de la granulomatose maligne pleuro-pulmonaire, Jr. de méd. de Lyon, 1931, xii, 733-745. Google Scholar15. MOOLTEN SM: Hodgkin's disease of the lung, Am. Jr. Cancer, 1934, xxi, 253-294. CrossrefGoogle Scholar16. ACHARD C: Granulomatose maligne a debut pleural, Rev. Gen. de Clin. et de Therap., 1931, vl, 177-183. Google Scholar17. LOWSLEYHANAH OSFW: Enlargement of the prostate gland with characteristics resembling Hodgkin's disease, Ann. Surg., 1927, lxxxvi, 556-560. CrossrefGoogle Scholar18. THOMPSONHOWELS TL: Primary lymphogranuloma of stomach, Quart. Jr. Med., 1935, iv, 81-91. Google Scholar19. EWING J: The thymus and its tumors, Surg., Gynec. and Obst., 1916, xxii, 461-472. Google Scholar20. GOODMAN LM: Hodgkin's disease mistaken for thyroid tumor, Am. Jr. Med. Sci., 1934, clxxxvii, 744-746. CrossrefGoogle Scholar21. STERNBERG C: Lymphogranulomatosis, Klin. Wchnschr., 1925, iv, 529-534. CrossrefGoogle Scholar22. UDDSTROMER M: Über die Lymphogranulomatose der Gebärmutter, Virchow's Arch. f. path. Anat., 1933, cclxxxix, 486-492. CrossrefGoogle Scholar23. EVANSLEUCUTIA WAT: Deep roentgen-ray exposure as an aid in the differential diagnosis of mediastinal tumors, Jr. Am. Med. Assoc., 1925, lxxxv, 1215-1219. CrossrefGoogle Scholar24. CHEVALLIERBERNARD PJ: La maladie de Hodgkin, 1932, Masson et Cie, Paris. Google Scholar25. WALLHAUSER A: Hodgkin's disease, Arch. Path., 1933, xvi, 522-562, 672-712. Google Scholar26. KUNDRAT : Über Lympho-Sarkomatosis, Wien. klin. Wchnschr., 1893, vi, 211-213, 234-239. Google Scholar27. POHLERITCHIE EAG: Lymphosarcoma of the femur, Radiol., 1932, xviii, 635-637. CrossrefGoogle Scholar28. GRAVES S: Primary lymphosarcoma of intestines, Jr. Med. Res., 1919, xl, 415-431. Google Scholar29. BERARDDENIS : Enormes lymphosarcomes multiples de l'intestin grele. Occlusion intestinale, resection de plus d'un metre d'intestin, Lyon Chir., 1931, xxviii, 522-523. Google Scholar30. FINSTERER H: Über Dündarmsarkome. Achtjährige Heilung eines Lymphosarkoms des Jejunums, Med. Klin., 1933, 485-487. Google Scholar31. RANKINCHUMLEY FWC: Lymphosarcoma of the colon and rectum, Minn Med., 1929, xii, 247-253. Google Scholar32. HARPER FR: Excision of lymphosarcoma of stomach 10 years after lymphosarcoma of cecum treated by roentgen-rays, Proc. Staff Meet. Mayo Clin., 1932, vii, 515-518. Google Scholar33. O'DONNEL F: Two cases of lymphosarcoma of the lung, Irish Jr. Med., 1926, vi, 324-326. CrossrefGoogle Scholar34. JOBIN J: Un cas de tumeur du poumon, Bull. Soc. méd. d. hop. Univ. de Quebec, 1932, xxxiii, 127-133. Google Scholar35. LUSCHERSCARTAZZANI EH: Zur Diagnose und Behandlung der Lymphosarkome der oberen Luft-und-Speiswege, Schweiz. med. Wchnschr., 1931, 193-201. Google Scholar36. WORMSDELATER GG: Destruction totale de l'hypophyse par tumeur d'origine rhinopharyngee sans syndrome dit hypophysaire, Rev. Neurol., 1925, ii, 361-369. Google Scholar37. COLEMARTIN FHLR: Lymphosarcoma of the prostate, Jr. Urol., 1934, xxxi, 803-811. CrossrefGoogle Scholar38. SZATHMARY G: Beiträge zum Krankheitsbild des Lymphosarkoma cutis, Arch. f. Dermat., 1933, clxix, 539-542. Google Scholar39. BRODERSMAHLE ACAE: Primary lymphosarcoma of the stomach. A report of 12 cases, Jr. Lab. and Clin. Med., 1921, vi, 249-252. Google Scholar40. CROSBY EH: Malignant tumors of the thymus, Am. Jr. Cancer, 1932, i, 461-486. Google Scholar41. RICE CO: Das Lymphosarkom der Schilddrüse, Virchow's Arch. f. path. Anat., 1932, cclxxxvi, 459-475. CrossrefGoogle Scholar42. BERVEN EG: Malignant tumors of the tonsil. A clinical study with special reference to radiological treatment, Acta Radiol., 1930-1931, Suppl. 10-13. Google Scholar43. GORDON MH: Studies on the etiology of lymphadenoma; in Rose Research on Lymphadenoma, 1932, John Wright and Sons, Ltd., London, pp. 9-76. Google Scholar44. MCALPIN KR: Blood counts in Hodgkin's disease, Arch. Int. Med., 1923, xxxii, 954-957. CrossrefGoogle Scholar45. JACOBS J: Zur Behandlung der Lymphogranulomatose, Strahlenth., 1930, xxxv, 533-538. Google Scholar46. LEVIN I: Lymphoma malignum (Hodgkin's disease) and lymphosarcoma, Jr. Am. Med. Assoc., 1931, xcvi, 421-426. CrossrefGoogle Scholar47. GILBERTBABAIANTZ RL: Notre methode de roentgenotherapie de la lymphogranulomatose (Hodgkin): resultates eloignes, Acta Radiol., 1931, xii, 523-529. CrossrefGoogle Scholar48. DESJARDINS AU: Radiotherapy for Hodgkin's disease and lymphosarcoma, Jr. Am. Med. Assoc., 1932, xcix, 1231-1236. CrossrefGoogle Scholar49. CRAVER LF: Five year survivals in lymphatic tumors, Surg., Gynec. and Obst., 1935, lx, No. 2a, 485. Google Scholar50. CUTLER M: Lymphosarcoma: a clinical, pathologic and radiotherapeutic study, with a report of 30 cases, Arch. Surg., 1935, xxx, 405-441. CrossrefGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: New York, N. Y.*Received for publication October 2, 1935.From the Radiotherapy Department and the Surgical Division, Cancer Service, Montefiore Hospital, New York, N. Y. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byKlinik, Behandlung und Statistik der SarkomeCytologie und Klinik der LymphogranulomatoseUnusual Morphologic Changes in the Liver in a Case of Acute Hepatic Failure 1 September 1936Volume 10, Issue 3Page: 337-372KeywordsAnemiaHodgkin lymphomaLymphSpleen ePublished: 1 December 2008 Issue Published: 1 September 1936 PDF downloadLoading ...