tbuckley/cabot-search huggingface dataset:
The Management of Severe and of Atypical Hyperthyroidism
Authors: Frank H. Lahey
Journal: Annals of Internal Medicine (1932)

Article1 March 1932The Management of Severe and of Atypical HyperthyroidismFRANK H. LAHEY, M.D.FRANK H. LAHEY, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-5-9-1123 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptWe wish to call attention to two thyroid states concerning which very little appears in the literature, and both of which possess very serious possibilities of fatalities unless properly appreciated and properly managed. The first is the patient with very severe hyperthyroidism bordering upon the so-called thyroid crisis, and the second is the state which we have termed apathetic thyroidism.SEVERE HYPERTHYROIDISMPatients with exophthalmic goitre apparently have the faculty of not infrequently leading their medical advisors into a false sense of security. This is perhaps due to the fact that patients with this disease are notably optimistic. Clinically this... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Boston, Mass.*Scheduled for presentation at the Baltimore Meeting of the American College of Physicians, March 26, 1931. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byTHE THYROTOXIC MYOPATHIESAGING AND COGNITIONCase Report Hyperthyroxinemia and Hypotriiodothyroninemia with Clinical EuthyroidismClinical studies of thyrotropin and thyrotropin-releasing-hormoneAPATHETIC THYROIDISM: REVIEW OF THE LITERATURE AND REPORT OF FOUR CASES*ROBERT RAY MCGEE, M.D., RICHARD L. WHITTAKER, M.D., I. FRANK TULLIS, M.D., F.A.C.P.The Medical Thyroid CrisisPostoperative Thyroid StormAcute Thyrotoxic Encephalo- or Myopathy, its cause and treatmentDie thyreotoxische Krise, das thyreotoxische Coma 1 March 1932Volume 5, Issue 9Page: 1123-1128KeywordsHyperthyroidismThyroid ePublished: 1 December 2008 Issue Published: 1 March 1932 PDF downloadLoading ...
Non-EU students flock to Ireland for medical training
Authors: Doug Payne
Journal: BMJ (2001)

More than half of the available places for medical training in the Republic of Ireland are being filled by students from other countries, most of them outside the European Union, according to new figures released by the Department of Education last week. The figures, given in reply to a parliamentary question, contained a further surprise—almost 200 Irish students turned down offers of places last year.

A total of 658 students began their medical training at Irish educational institutions last year. Of these, 320 came from states outside the European Union and 35 from other EU countries, …
Inhibition of chronic ulcerative colitis-associated carcinogenesis in mice by inositol compounds
Authors: Jie Liao, Darren N. Seril, Yuhai Sun, Guang-Yu Yang
Journal: Cancer Research (2005)

2471  Long-standing ulcerative colitis (UC) is a typical chronic inflammatory disease associated with increased risk for colorectal carcinoma development. In order to develop the strategies for preventing UC-associated carcinogenesis, we tested the effects of inositol compounds [including inositol and hexaphosphate inositol] on UC-associated adenocarcinoma development in a mouse model established in our laboratory. Female C57BL/6 mice were subjected to long-term, cyclic dextran sulfate sodium (DSS) treatment and fed 2-fold iron-enriched diet to induce chronic UC and UC-associated carcinogenesis. The inositol compounds were administered to the animals in the drinking fluid. In the DSS positive control group, colorectal adenocarcinoma incidence was 70.6% (24/34 mice) after 15 cycle DSS treatment (1 DSS cycle = 7 day DSS treatment period followed by 10 day recovery period). The tumor multiplicity was 1.26 ± 1.05, and tumor volume was 21.4 ± 5.2 mm3. With administration of 1% inositol, tumor incidence was statistically significantly inhibited (42%, 9 of 21 mice with tumor), as was tumor multiplicity (0.5 ± 0.7), and tumor volume (4.2 ± 1.9 mm3). Administration of hexaphosphate inositol markedly reduced tumor incidence (50%, 12 of 24 mice with tumor), tumor multiplicity (0.8 ± 0.9) and tumor volume (12.3 ± 4.1 mm3); however, they were not statistically significant (p>0.05). Further mechanistic studies using immunohistochemical approaches showed that inositol compounds significantly reduced macrophage activity, numbers, and its mediated nitrotyrosine formation in the colon. Inositol also showed significant inhibition of cell proliferation in both inflamed colonic mucosa and adjacent non-inflamed mucosa without affecting ulcer healing. These results indicate that inhibition of UC-associated carcinogenesis by inositol might relate to their function on the inhibition of macrophage-associated inflammation, nitro-oxidative stress, and cell proliferation in the process of inflammation and carcinogenesis. This study indicates that the inositol compounds may have a potential to serve as a preventive agent for inflammation and carcinogenesis. (supported by NIH 1R01CA104741-01A1 grant and research project grant RPG-00-034-01-CNE from the American Cancer Society and correspodence author: Guang-Yu Yang).
Explanations of socioeconomic differences in excess risk of type 2 diabetes in Swedish men and women : Diabetes Care
Authors: E. E. Agardh, A. Ahlbom, T. Andersson, S. Efendic, V. Grill, J. Hallqvist, C. G. Ostenson
Journal: Diabetes Care (2004)

Explanations of socioeconomic differences in excess risk of type 2 diabetes in Swedish men and women : Diabetes Care
The Radiobiology of Human Cancer Radiotherapy.
Authors: Justin J. Stein
Journal: Annals of Internal Medicine (1979)

benign vs. early myelGema are discussed.The author leans heavily on maintenance of a stable level of gamma- globulin for diagnosis of benign disease.The book in- cludes discussions on the concept of autoimmune diseases, the entity of purpurahypergammaglobulinemia and ma- lignant disease in general.The latter subject is again treated anecdotically and as such is more interesting for its speculations than for its hard data.The book is of interest primarily to internists and those physicians who see numbers of patients with ma- lignant disorders.It is worth reading particularly for the enjoyment of traveling through the years of observation and thinking of this monumental physician.
Abstract 1378: Calcium-Dependent Tyrosine Kinase PYK2 Plays Crucial Role in Angiotensin II- but Not Norepineprine-Mediated Activation of Rac/Superoxide Pathway that Differentially Regulates Blood Pressure and Vasoconstriction
Authors: Akihiro Matsui, Mitsuhiko Okigaki, Asako Katsume, Che Jishan, Shinichiro Yamaguchi, Hiroyuki Yamada, Hiroaki Matsubara
Journal: Circulation (2007)
Soluble CD40 ligand is not elevated in plasma of patients with chronic spontaneous urticaria
Authors: T. Jasinska, A. Kasperska-Zając
Journal: British Journal of Dermatology (2012)

Journal Article Soluble CD40 ligand is not elevated in plasma of patients with chronic spontaneous urticaria Get access T. Jasinska, T. Jasinska Department of Dermatology, Regional Specialized Hospital no. 4 in Bytom, Poland Search for other works by this author on: Oxford Academic Google Scholar A. Kasperska‐Zając A. Kasperska‐Zając Alicja Kasperska‐Zając. E‐mail: kasperska@plusnet.pl Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 167, Issue 2, 1 August 2012, Pages 450–452, https://doi.org/10.1111/j.1365-2133.2012.10908.x Published: 01 August 2012
THROMBOCYTOPENIC PURPURA FOLLOWING THE USE OF SULFATHIAZOLE
Authors: Paul S. Strong, Edward M. Glassburn
Journal: Annals of Internal Medicine (1945)

Case Reports1 August 1945THROMBOCYTOPENIC PURPURA FOLLOWING THE USE OF SULFATHIAZOLEPAUL S. STRONG, EDWARD M. GLASSBURNPAUL S. STRONGSearch for more papers by this author, EDWARD M. GLASSBURNSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-23-2-237 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThrombocytopenic purpura following the use of the sulfonamides is a rare but serious complication. In some instances it appears to be the result of an acquired sensitivity to the drug, whereas in others it represents a true idiosyncrasy and may follow the initial experience with the sulfonamide. Werner1reported a case of thrombocytopenia which appeared after the administration of only 1 gram of sulfathiazole. This patient had a history of having received the same drug 20 days before without reaction. Toxic thrombocytopenia was described by Goldbloom et al.2in a 50 year old female who had received only 6 grams...Bibliography1. WERNER WI: Thrombocytopenic purpura following administration of sulfathiazole, Southwest. Med., 1942, xxvi, 49. Google Scholar2. GOLDBLOOMGREENWALDREINSTEIN AALH: Toxic reactions to sulfapyridine, Jr. Lab. and Clin. Med., 1941, xxvii, 139. Google Scholar3. HURDJACOX RWRF: Thrombopenic purpura developing as a complication of sulfathiazole and sulfadiazine therapy, Jr. Am. Med. Assoc., 1943, cxxii, 296. CrossrefGoogle Scholar4. DICKDICK GFGH: Scarlet fever, 1938, The Year Book Publishers, Chicago, Illinois. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: *Received for publication March 6, 1944. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byArzneiexanthemeSulfonamideALLERGY, ANTIBIOTICS AND CHEMOTHERAPEUTICSDie pathogenetische Bedeutung der Allergie für Blut- und Knochenmarksschäden 1 August 1945Volume 23, Issue 2Page: 237-240KeywordsDrugsSulfonamide Issue Published: 1 August 1945 PDF downloadLoading ...
THE NOCTURNAL GASTRIC SECRETION IN PATIENTS WITH BENIGN GASTRIC ULCER
Authors: E LEVIN, J B KIRSNER, W L PALMER
Journal: Annals of Internal Medicine (1949)

Article1 May 1949THE NOCTURNAL GASTRIC SECRETION IN PATIENTS WITH BENIGN GASTRIC ULCERERWIN LEVIN, M.A., M.D., JOSEPH B. KIRSNER, M.D., F.A.C.P., WALTER LINCOLN PALMER, M.D., F.A.C.P.ERWIN LEVIN, M.A., M.D.Search for more papers by this author, JOSEPH B. KIRSNER, M.D., F.A.C.P.Search for more papers by this author, WALTER LINCOLN PALMER, M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-30-5-1020 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptINTRODUCTIONThe results of studies on the nocturnal gastric secretion of normal individuals and of patients with duodenal ulcer, gastric ulcer and gastric carcinoma have been summarized in a previous publication.1Although the number of patients with gastric ulcer in the original series was small, the data were sufficiently constant to indicate certain trends. The series now has been increased sufficiently to permit definite conclusions. The purpose of this paper is to describe in detail the periodicity and variability of the nocturnal gastric secretion in such patients and to compare them with normal subjects and patients with duodenal ulcer. To...Bibliography1. LEVINKIRSNERPALMERBUTLER EJBWLC: The fasting nocturnal gastric secretion in normal individuals and in patients with duodenal ulcer, gastric ulcer and gastric carcinoma, Arch. Surg., 1948, lvi, 345. CrossrefGoogle Scholar2. LEVINKIRSNERPALMERBUTLER EJBWLC: The variability and periodicity of the nocturnal gastric secretion in normal individuals, Gastroenterology, 1948, x, 939. Google Scholar3. LEVINKIRSNERPALMERBUTLER EJBWLC: A comparison of the fasting nocturnal gastric secretion in patients with duodenal ulcer and in normal individuals, Gastroenterology, 1948, x, 952. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Chicago, Illinois*Received for publication June 10, 1948.From the Frank Billings Medical Clinic, Department of Medicine, University of Chicago. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byContent of Gastric Inhibitory Substance in Saliva of Patients with Various Gastric DisordersSome notes on the pathogenesis of duodenal ulcerThe problem of peptic ulcer 1 May 1949Volume 30, Issue 5Page: 1020-1032KeywordsDuodenal ulcersGastric ulcers ePublished: 1 December 2008 Issue Published: 1 May 1949 PDF downloadLoading ...
Laboratory Manual for the Detection of Poisons and Powerful Drugs.
Authors: Wilhelm Autenrieth, Wilhelm Horner Warren
Journal: JAMA (1928)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Cost‐of‐illness of patients with chronic hand eczema in routine care: results from a multicentre study in Germany
Authors: M. Augustin, D. Kuessner, S. Purwins, K. Hieke, J. Posthumus, T.L. Diepgen
Journal: British Journal of Dermatology (2011)

It is broadly assumed that costs caused by chronic hand eczema (CHE) are significant. However, there is a lack of cost-of-illness studies on CHE.To determine the direct and indirect costs of CHE under routine conditions in Germany from the societal perspective.A cross-sectional survey was conducted in 24 outpatient practices and clinics across Germany. Patients with CHE refractory to potent topical steroids and insured by statutory health insurance were eligible. Clinical and cost data were collected using standardized questionnaires. Severity classes were defined according to a photographic guide and physician global assessment (PGA). Four treatment stages were defined based on the German CHE guidelines: topical treatments only (stage I), additionally ultraviolet (UV) radiation therapy (II), systemic therapy (III) and inpatient treatment (IV). Bivariate associations between costs and severity as well as treatment stage were assessed.Two hundred and twenty-three patients with CHE (mean age 45·7years, 56% women) enrolled in the study, of whom 63·2% were treated only with topical treatments, 15·7% additionally with UV radiation and 11·7% with systemic treatments. Of all patients, 9·4% had been admitted to hospital. Total costs per year and patient were €2128, including €1742 direct costs and €386 indirect costs. The total costs increased with treatment stages I-IV (P<0·001): €1044, €2307, €2697 and €8407, respectively. Accordingly, costs also correlated with clinical severity.Patients with CHE refractory to topical steroids incur marked costs to society. The costs increase disproportionately with escalating treatment stages, especially in patients admitted to hospital. Hence, new treatments may help to reduce the societal costs of CHE.
Effect of Local or Distal Therapeutic Treatment With Polyinosinic-Polycytidylic Acid on Survival of Mice With Ehrlich Carcinoma
Authors: H. G. duBuy
Journal: JNCI Journal of the National Cancer Institute (1972)

The differential effect of prolonged local or distal therapeutic treatment with polyinosinic-polycytidylic acid (poly I:C) on the survival time of mice inoculated at different sites with the same line of Ehrlich ascites carcinoma was studied. The mice with tumor cells given intraperitoneally (ip) and developing ascites tumors survived significantly longer when given poly I:C treatment ip, as compared with subcutaneous (sc) treatment. But mice with tumor cells given sc and developing solid tumors survived only slightly longer when given local sc treatment, as compared with systemic ip treatment. All treated groups survived significantly longer than the corresponding control groups. These findings are consistent with the interpretation that the more contact of the individual cancer cells with poly I:C, the more effective the treatment.
IS THERE AN INTRINSIC ASTHMA?
Authors: G L WALDBOTT
Journal: Annals of Internal Medicine (1947)

Article1 June 1947IS THERE AN INTRINSIC ASTHMA?GEORGE L. WALDBOTT, M.D., F.A.C.P.GEORGE L. WALDBOTT, M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-26-6-863 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe classification of patients with bronchial asthma into two groups, namely, extrinsic and intrinsic, was first advocated by Walker1in 1918. When the patients exhibited positive skin reactions, the disease was supposedly associated with external causative agents; in patients with negative reactions, so-called intrinsic causes, especially sensitivity to bacteria, were held responsible. Rackemann2reported in 1927 that among 1,074 asthmatic patients there were an equal number of extrinsic and intrinsic cases. These investigators did not enlarge upon the clinical manifestations or pathological lesions in order to substantiate their classification which is accepted by most authorities. Since less reliance is now...Bibliography1. WALKER IC: A clinical study of 400 patients with bronchial asthma, Boston Med. and Surg. Jr., 1918, clxxix, 288. CrossrefGoogle Scholar2. RACKEMANN FM: Studies in asthma: (1) a clinical survey of 1074 patients with asthma followed for two years, Jr. Lab. and Clin. Med., 1927, xii, 1185. Google Scholar3. COHEN MB: Bronchial asthma: classification based on etiological and pathological factors, Ann. Int. Med., 1944, xx, 590-596. Google Scholar4. WALDBOTTSNELL GLAD: Pulmonary lesions resembling pneumonia as the result of allergic shock, Jr. Pediat., 1935, vi, 229. CrossrefGoogle Scholar5. WALDBOTT GL: Emergency treatment in asthma (asthmatic crisis), Jr. Am. Med. Assoc., 1938, cx, 1423-1427. CrossrefGoogle Scholar6. COHENKLINERUDOLPH MBBSYA: Histologic changes in allergic and non-allergic wheals, Jr. Allergy, 1932, iii, 531. Google Scholar7. WALDBOTTBAILEY GLLJ: Estrogenic hormone determinations in premenstrual asthma, Jr. Allergy, 1942, xiii, 125-131. CrossrefGoogle Scholar8. ZONDEKBRONBERG BYM: Endocrine allergy: allergic sensitivity to endogenous hormones, Jr. Allergy, 1945, xvi, 1-16. CrossrefGoogle Scholar9. URBACH E: Allergy, 1943, Grune and Stratton, New York. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: *Received for publication April 20, 1946. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byAsthma bronchiale 1 June 1947Volume 26, Issue 6Page: 863-872KeywordsAsthmaBacteriaLesionsPatient advocacySkin diseasesSkin reaction ePublished: 1 December 2008 Issue Published: 1 June 1947 PDF downloadLoading ...
A memorable patient: Beware ill relatives who request second opinions
Authors: D. Fisher
Journal: BMJ (2002)

Against my better judgment, I was persuaded by two of my wife's elderly spinster aunts to examine their sister, another spinster. “She's just not right,” I was told by telephone. She arrived the following morning after a car journey of some 150 miles, and they had been correct—she was not right, she was in left heart failure. Subsequent examination in hospital also revealed that she had advanced syringomyelia and cancer of the breast, with widespread deposits. She died peacefully six days later. After passing on the sad news to the aunts, I was somewhat tartly told that she had willed her body to medical science, and would I kindly deal with it.

Ella, for that was her name, proved difficult to deal with. Getting the correct forms signed and witnessed by her …
Abstract 13644: The Increment of Serum Creatinine Level on the Next Day Predicts the Development of Contrast Induced Nephropathy
Authors: Makoto Watanabe, Yoshihiko Saito, Kazutaka Aonuma, Atsushi Hirayama, Nagara Tamaki, Hiroyuki Tsutsui, Toyoaki Murohara, Hisao Ogawa, Takashi Akasaka, Michihiro Yoshimura, Akira Satoh, Tadateru Takayama, Mamoru Sakakibara, Susumu Suzuki, Kenichi Ishigami
Journal: Circulation (2014)

Background: Contrast induced nephropathy (CIN) has been a subject of concern to cardiologists in recent year because CIN is associated with increased mortality. But we cannot evaluate the development of CIN in almost Japanese patients because these patients are discharged on next day after cardiac catheterization. Objective: The aim of this study is to investigate whether the serum creatinine level (Scr) on the next day after cardiac catheterization can predict the development of CIN. Methods: This study, named the study for CIN after cardiac catheterization in Japan (the CINC-J study), is a multicenter cohort study, which examined 1021 patients undergoing cardiac catheterization from 29 hospitals in all over Japan. CIN was defined as an increase in Scr of 0.5mg/dl or 25% from 48 to 72 hours after contrast-medium injection. The change amount of Scr was defined as the increment of Scr (Scr on the next day - Scr on admission) and the change amount of eGFR was defined as the decrement of eGFR (eGFR on admiss...
What is the relationship between inspiratory capacity and different measures of exercise capacity in patients with COPD
Authors: Leila Donária, Rafael Mesquita, Camila Monteiro Mazzarin, Isabel Cristina Hilzert Genz, Vanessa Suziane Probst, Nidia Aparecida Hernandes, Fábio Pitta
Journal: European Respiratory Journal (2012)

Background:  Inspiratory capacity (IC) is an indirect measure of pulmonary hyperinflation in patients with chronic obstructive pulmonary disease (COPD), and may be a limiting factor to exercise capacity in this population. However, the relationship of IC with exercise capacity still needs to be better explored.  Objective:  To investigate the relationship between inspiratory capacity and different measures of exercise capacity in subjects with COPD.  Methods:  Thirty patients with COPD (16 men, 66±8 years, forced expiratory volume in the first second [FEV 1 ] 40±14% pred) were studied. Inspiratory capacity was assessed by post-bronchodilator spirometry, whereas exercise capacity was assessed by the following three tests: six-minute walking test (6MWT), incremental symptom-limited cycle ergometry test (ISL) and constant work rate cycle ergometry test (CWR), all tests performed according to international guidelines.  Results:  In the 6MWT, IC (in liters) explained 18% (p=0.02) of the distance walked, whereas in the ISL it explained 23% (p=0.008) of maximum work load and 19% (p=0.02) of heart rate reached at the end of the test. In the CWR, IC showed only a simple negative correlation with oxygen saturation at the end of the test (r=-0.48).  Conclusion:  The inspiratory capacity significantly contributes, albeit modestly, to some key variables of exercise capacity tests. This indicates that a greater ventilatory reserve may be related to better physical fitness, and hence to a lower chance of hyperinflation.