tbuckley/cabot-search huggingface dataset:
Abstract 4280: Integrative analyses of multi-omics sequencing data to guide treatment decisions in a patient with double malignancy
Authors: Wei Zhu, Jiaqi Huang, Brandon W. Higgs, Philip Brohawn, Shujun Dai, Laura Richman, Bahija Jallal, Liyan Jiang, Yihong Yao
Journal: Cancer Research (2014)

Abstract Multiple primary malignancies are becoming common. The number of second or higher-order cancers is burgeoning and accounted for about 16% of incident cancers. Double malignancy cases pose the problem of finding the best treatment for the patient. Next generation sequencing (NGS) was used in this study to characterize the genetic and genomic composition in a patient with multiple cancer syndromes. A lung adenocarcinoma brain metastasis sample (FFPE) naïve to any tumor therapy, and relapsed primary lung adenocarcinoma and ovarian serous carcinoma tumor biopsies (fresh frozen) were procured from a 51-year old Chinese female never-smoker. The primary lung and ovarian cancer samples were post to the treatments with both first line and EGFR-TKI targeted therapy. Multiple NGS approaches were conducted on the patient biopsies, including DNA whole genome/exome sequencing, RNA sequencing, and microRNA sequencing. Integrative analyses of the comprehensive NGS data indicated EGFR exon 19 deletions in-frame, which encode part of the kinase domain presented in both primary lung cancer and its brain metastases. EGFR T790M mutation which accounts for the resistance of lung tumor to the EGFR-TKI therapy was identified in the relapsed lung sample but not in the brain malignancy. These results were well aligned with the clinical response to EGFR-TKI treatment in the patient. Furthermore, we uncovered frequent occurrences of somatic copy number variations in both lung and ovarian tumors. A somatic non-sense mutation (COSMIC ID: 307331) in TP53 was uniquely identified in the ovarian tumor biopsy, suggesting a different mechanism driving tumorigenesis than that in the lung. Besides, we also identified a heterozygous insertion in DUSP16 and a stop code gained mutation in MAP3K15 in the patient's germline DNA, a potential predisposition of multiple cancer syndromes and early onset of tumor in this patient. Finally, structural variation and gene fusion, gene interaction, pathway analysis of the affected genes were integrated and evaluated. Overall, NGS approaches shed insights into the molecular phenotypes of tumors and thus have the potential to provide the physician key scientific rationale to design targeted therapeutic approaches in the treatment course. Citation Format: Wei Zhu, Jiaqi Huang, Brandon W. Higgs, Philip Brohawn, Shujun Dai, Laura Richman, Bahija Jallal, Liyan Jiang, Yihong Yao. Integrative analyses of multi-omics sequencing data to guide treatment decisions in a patient with double malignancy. [abstract]. In: Proceedings of the 105th Annual Meeting of the American Association for Cancer Research; 2014 Apr 5-9; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2014;74(19 Suppl):Abstract nr 4280. doi:10.1158/1538-7445.AM2014-4280
Successful treatment of systemic cold contact urticaria with etanercept in a patient with psoriasis
Authors: G. Gualdi, P. Monari, M.T. Rossi, S. Crotti, P.G. Calzavara-Pinton
Journal: British Journal of Dermatology (2011)

Journal Article Successful treatment of systemic cold contact urticaria with etanercept in a patient with psoriasis Get access G. Gualdi, G. Gualdi Department of Dermatology, University of Brescia, 25123 Brescia, Italy Search for other works by this author on: Oxford Academic Google Scholar P. Monari, P. Monari Department of Dermatology, University of Brescia, 25123 Brescia, Italy Search for other works by this author on: Oxford Academic Google Scholar M.T. Rossi, M.T. Rossi Department of Dermatology, University of Brescia, 25123 Brescia, Italy Maria Teresa Rossi E‐mail: E‐mail: mariateresa.rossi@alice.it Search for other works by this author on: Oxford Academic Google Scholar S. Crotti, S. Crotti Department of Dermatology, University of Brescia, 25123 Brescia, Italy Search for other works by this author on: Oxford Academic Google Scholar P.G. Calzavara‐Pinton P.G. Calzavara‐Pinton Department of Dermatology, University of Brescia, 25123 Brescia, Italy Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 166, Issue 6, 1 June 2012, Pages 1373–1374, https://doi.org/10.1111/j.1365-2133.2011.10797.x Published: 01 June 2012
Abstract 14162: Assessment of Aortic Morphology in Patients with Bicuspid Aortic Valve: Echo vs CMR
Authors: Kameswari Maganti, Tonye Teme, Qiong Zhao, Judith Meadows, Mikati A Issam, Robert O Bonow
Journal: Circulation (2011)

Background: Bicuspid aortic valve (BAV) is a common congenital cardiac abnormality, often involving aneurysmal dilatation of the aorta. Recent guidelines recommend screening of aortic size and peri...
"No longer Gage": an iron bar through the head
Authors: K. O'Driscoll, J. P. Leach
Journal: BMJ (1998)

In September 1848, in Cavendish, Vermont, an incident occurred which was to change our understanding of the relation between mind and brain. Phineas P Gage, a 25 year old railroad foreman, was excavating rock. In preparation for blasting he was tamping powder into a drill hole when a premature explosion drove the tamping iron —.1.1  m long, 6 mm in diameter, and weighing 6 kg — through his left cheek and out of the vault of his skull with such force that it threw him on his back and fell several rods behind, “smeared with brain.”1 Despite his injuries he remained conscious and only a few minutes later was sitting in an ox cart writing in his work book. He recognised and reassured Dr Harlow, who had been summoned to the scene. The wound continued to bleed for two days; then followed a virulent infection that rendered Gage semiconscious for a month. His condition was so poor that a coffin had been prepared. Nevertheless, Dr Harlow continued treatment, and by the fifth week the infection had resolved and Gage had regained …
SPONTANEOUS ARTERIOVENOUS COMMUNICATION BETWEEN THE AORTA AND SUPERIOR VENA CAVA
Authors: Lamont R. Schweiger, Howard B. Burchell, Archie H. Baggenstoss
Journal: Annals of Internal Medicine (1943)

Case Reports1 December 1943SPONTANEOUS ARTERIOVENOUS COMMUNICATION BETWEEN THE AORTA AND SUPERIOR VENA CAVALAMONT R. SCHWEIGER, M.D., HOWARD B. BURCHELL, M.D., ARCHIE H. BAGGENSTOSS, M.D.LAMONT R. SCHWEIGER, M.D.Search for more papers by this author, HOWARD B. BURCHELL, M.D.Search for more papers by this author, ARCHIE H. BAGGENSTOSS, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-19-6-1029 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptSpontaneous communications between the large arteries and veins of the thorax occur with sufficient rarity to warrant a report of the following case.CASE REPORTA white woman, aged 45 years, registered at the Mayo Clinic December 16, 1940. She apparently had been well until two years before her registration at the clinic. At that time she had noted that she became fatigued very easily. Approximately one year before she came to the clinic she had noted that dyspnea and palpitation occurred on exertion. Because of the increasing severity of these symptoms in the next six months, she had been...Bibliography1. ARMSTRONGCOGGINHENDRICKSON ELCBHS: Spontaneous arteriovenous aneurysms of the thorax: a review of the literature, with a report of two cases, Arch. Int. Med., 1939, lxiii, 298-317. CrossrefGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Rochester, Minnesota*Received for publication December 15, 1941. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byErkrankungen der Venen im MediastinumKurzschlußverbindungen des großen und kleinen KreislaufsDie Chirurgie der BauchaortaSpontaneous perforation of an aortic aneurysm into the superior vena cava with survival for 136 daysRupture of aortic aneurysm into the superior vena cavaObstructions of the superior vena cavaThe superior vena caval syndrome; report of thirty-five cases 1 December 1943Volume 19, Issue 6Page: 1029-1034KeywordsAortaArteriesDyspneaThoraxVeins ePublished: 1 December 2008 Issue Published: 1 December 1943 PDF downloadLoading ...
Evolution of lung function in preterm infants with or without bronchopulmonary dysplasia
Authors: Manuel Sanchez-Solis, Luis Garcia-Marcos, Virginia Perez, Maria Dolores Pastor, Pedro Mondejar
Journal: European Respiratory Journal (2011)

Introduction: Healthy preterm infants do no catch-up lung function (LF) during the first two years of life. The aim of study is to compare the evolution of LF in infants born preterm, with and without BPD.

Methods: Forced vital capacity (FVC), forced expiratory flows at 50%, 75%, 25-75% of FVC (FEF50, FEF75, FEF25-75) and forced expiratory flow at 0.5 sec (FEV0.5), was obtained by raised volume rapid torachoabdominal compression technique (RVRTC) in 14 (7 males) BDP+ and in 12 (6 males) infants born preterm BPD-. Measurements were repeated at 6 and 12 moths after baseline. A generalized estimating ecuations (GEE) adjusted for gestational age, length, corrected age and body mass index z-score (according OMS tables) was built for boys and girls separately.

Results: 

View this table:

Table 1. Characteristics of BPD+





View this table:

Table 2. GEE coefficients of LF parameters of infants born preterm BPD+ (base: BPD–)





Conclusions: FVC, FEF25-75 and FEV0.5 decrease among male infants with BPD as compared to those without BPD; however in female infants they tend to be similar, and FEF50, FEF25-75 and FEV0.5/FVC even improve.
Minor histocompatibility antigens HA-1-, -2-, and -4-, and HY-specific cytotoxic T-cell clones inhibit human hematopoietic progenitor cell growth by a mechanism that is dependent on direct cell-cell contact
Authors: WA Marijt, WF Veenhof, E Goulmy, R Willemze, JJ van Rood, JH Falkenburg
Journal: Blood (1993)
Genetically encoded reporters for imaging signal transduction and protein interactions in vivo
Authors: David Piwnica-Worms
Journal: Cancer Research (2005)

Proc Amer Assoc Cancer Res, Volume 46, 2005

SY04-1 

The field of in vivo molecular imaging continues to present an extraordinary opportunity for studying cancer cell biology noninvasively in ways that were not possible only a few years ago. Indeed, the broad scope of scientific endeavor has begun to benefit from molecular imaging technologies that reveal cellular and molecular changes in the context of the living body. Such research is emerging at the foundation of probing molecular mechanisms of cancer wherein genetically-encoded imaging reporters introduced into cells and transgenic animals enable noninvasive, longitudinal studies of dynamic processes in vivo . When cloned into promoter/enhancer sequences or engineered into fusion proteins, imaging reporters enable transcriptional regulation, signal transduction, protein-protein interactions, oncogenic transformation, cell trafficking and targeted drug action to be spatiotemporally resolved in vivo . Spying on cancer with genetically-encoded imaging reporters provides insight into cancer-specific molecular machinery within the context of the whole animal.
Understanding Intestinal Spore-Forming Protozoa: Cryptosporidia, Microsporidia, Cyclospora
Authors: Richard W. Goodgame
Journal: Annals of Internal Medicine (1996)

Objectives: To summarize recent information about the "new" gastrointestinal protozoal pathogens (cryptosporidia, microsporidia, isospora, and cyclospora) and to help practicing clinicians integrate this information into their clinical databases by emphasizing the similarities among these organisms. Data Sources: Relevant English-language articles published between 1988 and 1995 were identified through a MEDLINE search done using the names of the intestinal spore-forming protozoa. Articles cited in the bibliographies of these and other articles were searched manually. Study Selection: Studies that contained information on the history, taxonomy, life cycle, epidemiology, pathogenesis, clinical manifestations, diagnosis, and treatment of the pathogens were reviewed. Data Extraction: Cryptosporidium parvum, Isospora belli, Cyclospora cayetanensis, Enterocytozoon bieneusi, and Septata intestinalis are intestinal spore-forming protozoa that cause intracellular infections, predominantly in the epithelial cells of the intestine. They are transmitted either by stool from person to person or through contaminated water or food by an infectious particle called a spore or oocyst. Asymptomatic infections occur; the most common symptom of infection is diarrhea. Infections have been associated with intestinal inflammation, disordered architecture (such as villus blunting), and abnormal function (for example, malabsorption). Mild to moderate, self-limited diarrhea is common in healthy persons, but patients with immune dysfunction can have severe intestinal injury and prolonged diarrhea. Diagnosis is made by a microscopic examination of the stool and the use of appropriate staining techniques. Effective antibiotic treatment for prolonged infection in immunocompromised patients is available for most of these infections. Conclusions: The intestinal spore-forming protozoa are four frequently identified gastrointestinal pathogens that have important similarities in epidemiology, disease pathogenesis, clinical manifestations, diagnosis, and treatment.
Complications After Surgery for Stress Urinary Incontinence
Authors: Christian P. Meyer, Quoc-Dien Trinh
Journal: JAMA Surgery (2015)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Surgery HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Surgery journal
Patient-reported gastrointestinal and genitourinary toxicity after prostate cancer treatment: A comparison between radiotherapy including pelvic nodes and prostate-only radiotherapy.
Authors: Per Fransson, Sebastian Olofsson, Anders Widmark, Camilla Thellenberg Karlsson
Journal: Journal of Clinical Oncology (2015)

22 Background: To evaluate side effects of radiotherapy (RT) including the pelvic nodes in patients with prostate cancer. Methods: 143 patients with high risk prostate cancer (Pca) receiving whole pelvic radiotherapy (WPRT) was matched to a group of 142 patients receiving RT towards the prostate and seminal vesicles only (PORT). Both groups were given 78 Gy towards the prostate and 50 Gy towards the seminal vesicles. The WPRT group also received 50 Gy towards the pelvic nodes. WPRT was given with intensity modulated RT or volumetric modulated arc therapy technique and the group treated towards the prostate and seminal vesicles only was treated with 3-dimensional conformal RT. Gastrointestinal (GI) and genitourinary (GU) side effects were evaluated with patient-reported questionnaires and with the RTOG scale, scored by treating physician, at baseline and one-year after RT. Results: Overall the side effects were mild. At one-year follow up there were significant differences regarding morning urgency, mucus- and blood in stool between the two groups (Table 1). The WPRT group expressed lesser complications in all of these cases. In the RTOG GU and GI scores there were no differences between the groups. About 20% had RTOG grade 2 GU score and 2%/1% had RTOG grade 3 score in the PORT and WPRT groups, respectively. The numbers for RTOG grade 2 GI scores were 11% and 5% in the PORT and WPRT groups, respectively. None of the groups reported RTOG grade 3 GI symptoms. Conclusions: Whole pelvic RT can be done with a very satisfying profile of side effects. Sometimes even lesser gastrointestinal reported side effects are seen with the newer techniques compared to prostate only radiotherapy with older techniques. [Table: see text]
774. Stability Study of an Adenoviral Vector Prepared in GTS: The Buffer Formulation of the Adenovirus Reference Material
Authors: Renald Gilbert, Francois Bouthillier, Bernard Massie
Journal: Molecular Therapy (2004)

Adenoviral vectors (AdVs) are among the most popular vectors for research and clinical applications. Following their growth and purification, AdVs are resuspended into buffer and salt formulations that are expected to preserve their integrity and infectious titer. A buffer formulation known as GTS (2.5% glycerol, 20 mM Tris pH 8, 25 mM NaCl) that provides stability through freeze-thaw stress and long-term storage, was recently developed (Hoganson et al., BioProcessing J., Vol 1, p. 43–48, March 2002). In the present study, we have investigated the stability confers by GTS on a first generation (E1+E3-deleted) AdV expressing the improved green fluorescent protein (GFPq) regulated by our optimized cytomegalovirus promoter (AdCMV5GFPq). The presence of GFPq in our vector allows for rapid, sensitive and accurate measurement of its infectious titer by flow cytometry following infection of 293A cells. AdCMV5GFPq was purified by two rounds of CsCl gradient centrifugation followed by dialysis in GTS. The concentration of fresh AdCMV5GFPq was determined by measuring its optical density at 260 nm and aliquots of 1.0 × 1012, 2.0 × 1011 and 5.0 × 1010 viral particles/ml (vp/ml) were prepared. The infectious titer of AdCMV5GFPq was then determined by flow cytometry for aliquots conserved at −80, −20 and 4°C for one week, two weeks, three weeks, one month, three months, six months and one year. The ratio of total viral particles vs infectious particle (total/inf) of the fresh AdV was 6.8. The infectious titer of AdCMV5GFPq did not decrease when kept at −80°C for one year. When frozen at this temperature, at least 4 cycles of freeze-thaw could be performed without affecting the infectious titer. The stability of AdV conserved at −20°C and 4°C was concentration dependent. At −20°C and at a concentration of 1.0 × 1012 vp/ml, AdCMV5GFPq did not lose infectivity after six months but was 50% less infectious after 1 year. At lower concentrations, the infectivity remained unchanged for one year. When kept at 4°C at a concentration of 1.0 × 1012 vp/ml, AdCMV5GFPq was stable for one month, but lost all its activity after three months. At lower concentrations, the infectious activity was stable for three months but dropped by 50% after six months. In conclusion, GTS is an excellent buffer formulation that provides complete stability for one year at −80°C, for six months at −20°C, and for one month at 4°C.
A framework for measuring the social impact of food allergy across Europe: a EuroPrevall state of the art paper
Authors: B. M. J. De Blok, B. J. Vlieg‐Boerstra, J. N. G. Oude Elberink, E. J. Duiverman, A. DunnGalvin, J. O'B. Hourihane, J. R. Cornelisse‐Vermaat, L. Frewer, C. Mills, A. E. J. Dubois
Journal: Allergy (2007)

This state of the art paper has been developed through EuroPrevall, a European multicentre research project funded by the European Union which aims to improve quality of life for food allergic individuals. Food allergy (whether clinically diagnosed or self-perceived) represents a major health issue in Western societies and may have a considerably greater impact on society than was previously believed. However, the social impact of food allergy has never been systematically investigated using validated instruments. Combining the information from studies on health-related quality of life (HRQoL) with epidemiological data on prevalence will ultimately give some indication of the magnitude of the social impact of food allergy in Europe. HRQoL can be assessed with disease-specific questionnaires, which are being developed in EuroPrevall. These instruments will be used to identify HRQoL problems associated with food allergy, and to assess the effectiveness of interventions and to guide the development of regulatory policies.
Abstract 12801: Angled Lesions Have Higher Incidence of Vascular Injury and Incomplete Stent Apposition, as Compared to Non-Angled Lesions, Following Stenting: An Optical Coherence Tomography Study
Authors: Yoshiyasu Minami, Shiro Uemura, Stephen Lee, Soo Joong Kim, Chang-Bum Park, Harold L Dauerman, Ik-Kyung Jang
Journal: Circulation (2014)

Backgrounds: Angled lesions are reported to be associated with worse procedural and clinical outcomes. Recent ex vivo studies have demonstrated that an angled arterial wall is exposed to imbalanced mechanical stress, which can cause vessel injuries and incomplete stent apposition (ISA) following stent implantation. Hypothesis: We tested the hypothesis that the angled coronary lesions, compared to non-angled lesions, would have higher incidence of vascular complications and ISA following stent implantation using optical coherence tomography (OCT) in patients. Methods: A total of 245 lesions treated with a single DES [95 zotarolimus-eluting stent (ZES) and 150 everolimus-eluting stent (EES)] were analyzed using OCT. An angled lesion was defined as a lesion on a curve ≥45° (n=59) on an angiogram and non-angled lesion on a curve &lt;45° (n=186). The frequency was expressed as the percentage of stents with at least one type of injury or strut malapposition. Vessel injury included edge dissection, in-stent dissection, thrombus, and tissue protrusion. ISA was defined when the distance between the center of strut and the vessel wall was &gt;100μm in ZES and &gt;90um in EES. Results: The incidence of edge dissection and tissue protrusion was not significantly different between the groups. However, the incidence of in-stent dissection (84.7% vs 63.4%, P&lt;0.01), thrombus (55.9% vs 35.5%, P&lt;0.01) and ISA (76.3% vs 44.6%, P&lt;0.001) was significantly higher in the angled group. The multivariate analysis demonstrated that the lesion on angle ≥60° was the independent predictor for in-stent dissection [Odds ratio (OR) 4.37, P=0.03] and ISA [OR 7.37, P&lt;0.01], and that the angle ≥45° was the independent predictor for thrombus [OR 2.94, P=0.01]. There was no difference in the OCT findings between the ZES and EES groups. Conclusion: Angled coronary lesions had higher incidence of in-stent dissection, thrombus and ISA compared with non-angled lesions following DES implantation as assessed by OCT.