THE SIGNIFICANCE OF SERUM COMPLEMENT LEVELS FOR THE DIAGNOSIS AND PROGNOSIS OF ACUTE AND SUBACUTE GLOMERULONEPHRITIS AND LUPUS ERYTHEMATOSUS DISSEMINATUS
Authors: K LANGE, E WASSERMAN, L B SLOBODY
Journal: Annals of Internal Medicine (1960)

Article1 October 1960THE SIGNIFICANCE OF SERUM COMPLEMENT LEVELS FOR THE DIAGNOSIS AND PROGNOSIS OF ACUTE AND SUBACUTE GLOMERULONEPHRITIS AND LUPUS ERYTHEMATOSUS DISSEMINATUSKURT LANGE, M.D., F.A.C.P., EDWARD WASSERMAN, M.D., LAWRENCE B. SLOBODY, M.D.KURT LANGE, M.D., F.A.C.P., EDWARD WASSERMAN, M.D., LAWRENCE B. SLOBODY, M.D.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-53-4-636 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptSince the original publication by Veil and Buchholz1 in 1932, in which they reported a lowering of serum complement in a few cases of acute glomerulonephritis, a number of investigators have studied this phenomenon, mostly in small numbers of cases and with short-term observations only.2, 3, 4For the last 10 years5, 6we have examined serum complement levels in 3,051 patients with varied kidney diseases, in addition to examinations in a great number of normal persons, and in patients with other disease conditions. Since we felt that the determination of serum complement levels (C') is an important and often...Bibliography1. VeilBuchholz WHB: Der Komplementschwund im Blute, Klin. Wchnschr. 11: 2019, 1932. CrossrefGoogle Scholar2. 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CrossrefGoogle Scholar14. KleinBurkholder PP: Ein Verfahren zur fluoreszenzoptischen Darstellung der Komplementbindung und seine Anwendung zur histo-immunologischen Untersuchung der experimentellen Nierenanaphylaxie, Deutsche med. Wchnschr. 84: 2001, 1959. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: New York, N. Y.*Received for publication April 29, 1960.Presented in part at the Forty-first Annual Session of The American College of Physicians, San Francisco, California, April 5, 1960.From the Departments of Medicine and Pediatrics of the New York Medical College, Metropolitan Medical Center, New York, N. Y.†The work was supported by grants from the Institute of Arthritis and Metabolism, U. S. Public Health Service, and grants from the Kidney Disease Foundation, New York, N. Y.Requests for reprints should be addressed to Kurt Lange, M.D., New York Medical College, 1 East 105th Street, New York 29, N. Y. 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