tbuckley/cabot-search huggingface dataset:
269 INTRAHEPATIC CHOLANGIOCARCINOMA (I-CC) OR MIXED HEPATOCELLULAR–CHOLANGIOCARCINOMA (HCC-CC) IN PATIENTS UNDERGOING LIVER TRANSPLANTATION. A SPANISH CASE CONTROL MULTICENTER STUDY
Authors: C. Rodríguez-Lope, G. Sapisochin, M. Gastaca, J. Ortiz de Urbina, R. López-Andujar, F. Palacios, E. Ramos, J. Fabregat, J.F. Castroagudin, E. Varo, J.A. Pons, P. Parrilla, L. González- Dieguez, M. Rodríguez, A. Otero, M.A. Vazquez, G. Zozaya, J.I. Herrero, G. Sánchez, B. Pérez-Saborido, R. Ciria, S. Rufían, Y. Fundora, A. Ferrón, A. Guiberteau, G. Blanco, M.A. Varona, M.A. Barrera, M.A. Suarez, J. Santoyo, R. Charco, J. Bruix
Journal: Journal of Hepatology (2013)
Clarifying the Nocebo Effect and Its Ethical Implications
Authors: Franklin G. Miller
Journal: The American Journal of Bioethics (2012)

Click to increase image sizeClick to decrease image size Acknowledgments This article is not subject to U.S. Copyright Law. The opinions expressed here are those of the author and do not reflect the position or policy of the National Institutes of Health, the Public Health Service, or the Department of Health and Human Services. This research was supported by the Intramural Research Program of the Clinical Center, NIH.
Cross-validation study of class III beta-tubulin as a predictive marker for benefit from adjuvant chemotherapy in resected non-small-cell lung cancer: analysis of four randomized trials
Authors: T. Reiman, R. Lai, A.S. Veillard, E. Paris, J.C. Soria, R. Rosell, M. Taron, S. Graziano, R. Kratzke, L. Seymour, F.A. Shepherd, J.P. Pignon, P. Sève
Journal: Annals of Oncology (2011)
EMERGENCY MEASURES AND PRECAUTIONS IN RADIUM ACCIDENTS
Authors: Eugene L. Saenger
Journal: JAMA (1952)

The escape of radium salts from sealed containers has, in several instances, resulted in expenditure of from $50,000 to $100,000 by the institutions where such accidents occurred. These figures may seem exceedingly high. They include, however, the costs of decontamination, medical care, legal advice, lost production time, and replacement of equipment that could not be decontaminated. In some instances such an accident has resulted in serious contamination of the exposed persons because of the absorption, inhalation, or ingestion of radium salts. On July 24, 1951, a platinum capsule containing 50 mg. of radium sulfate became opened at an industrial plant in Cincinnati. Within a few hours after the accident had been discovered, radium sulfate was spread rather widely throughout the plant. Several persons inhaled some of the radium at the time of the accident. A careful survey of the medical literature showed no readily available source of information as to
Effects of Undernutrition on Reproductive Function in the Human*
Authors: MICHELLE P. WARREN
Journal: Endocrine Reviews (1983)

A NUMBER of syndromes have recently been described which are associated with undernutrition and altered reproductive function. The syndromes described in women which include anorexia nervosa, amenorrhea associated with weight loss, bulimia, amenorrhea which occurs after oral contraceptives, postpartum amenorrhea, and amenorrhea associated with exercise all have hormonal patterns suggestive of hypothalamic alterations. Although the mechanisms are unknown, these problems appear to involve abnormalities affecting the central regulatory mechanism responsible for gonadotropin secretion, particularly those regulating pulse frequency, pulse amplitude and sleep associated patterns. These syndromes represent excellent models for the study and understanding of these important hypothalamic mechanisms as well as models for the understanding of puberty and the maturation of the pubertal hypothalamic-pituitary gonadal axis. The reproductive system, particularly in women, is extremely sensitive to alterations in its environment. The importance of homeostasis is exemplified by the reports of altered cyclicity during conditions of crowding, starvation, weight change, travel, communal living, exercise, and severe stress of any kind (1, 2).
Hypocalcaemia after intravenous bisphosphonate
Authors: Carlo Palmieri, Tony Dhillon, Charles Coombes, David Vigushin
Journal: BMJ (2004)

Editor-The Data Protection Act 1998 does not prohibit the processing of personal information for medical research purposes.Indeed, it is clear from section 33 of the act that such processing is expressly permitted.If it were otherwise, then the act would be in direct conflict with the core aims of the laws that underpin it-namely, the Council of Europe Convention of 1981 and the European Union Directive of 1995.These laws seek to facilitate data processing activities, primarily "free flows" of information, rather than suppress data processing.The problems to which Peto et al refer in their editorial on data protection, informed consent, and research are not Data Protection Act problems but, rather, problems caused by ignorance and misunderstanding. 1 With basic training on the key mechanisms of the act the problems of which the authors complain can be easily overcome.Training need not be an expensive task either.Legal compliance can be achieved at comparatively modest cost.There are two additional points of note.Firstly, the Data Protection Act regulates the processing of personal information relating to living individuals.Thus, research following death is not regulated.Secondly, the act and case law make clear that information will not be "personal data" if it does not identify a living person or if it does not have the individual as its focus or is not significantly biographical.So, if medical researchers do not actually need or seek identification information the act should not be engaged.
End of Routine Smallpox Vaccination in Childhood
Authors: WILLIAM H. FOEGE
Journal: Annals of Internal Medicine (1972)

Editorial Notes1 February 1972End of Routine Smallpox Vaccination in ChildhoodWILLIAM H. FOEGE, M.D., J. MICHAEL LANE, M.D.WILLIAM H. FOEGE, M.D.Search for more papers by this author, J. MICHAEL LANE, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-76-2-324 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptIn October 1971 the United States Public Health Service recommended the cessation of routine childhood smallpox vaccination. This decision was reached after several years of study and was based on a number of considerations.The World Health Organization's global smallpox eradication program has been highly successful and is expected to reach its objective of a smallpox-free world by 1976. Only eight countries still remain endemic for smallpox, and several of the eight are currently reaching a smallpox-free state.Largely because of the dramatic decrease in smallpox-endemic areas, the likelihood that smallpox will be imported to the United States has decreased... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Center for Disease Control Atlanta, Ga. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByThe discontinuation of routine smallpox vaccination in the United States, 1960-1976: an unlikely affirmation of biomedical hegemony 1 February 1972Volume 76, Issue 2Page: 324-325KeywordsGlobal healthMedical services Issue Published: 1 February 1972 PDF DownloadLoading ...
The Prediagnostic State of Lymphoma
Authors: Howard R. Bierman
Journal: JAMA (1963)

Twenty patients with ill-defined complaints of 7 months' to 10 years' duration were studied intensively for a hidden neoplastic focus. A diagnosis of preclinical lymphoma in the prediagnostic phase was made in all 20 patients on the basis of detailed clinical and laboratory tests. The appearance and persistence of an abnormal reticulum cell in leukocyte concentrates of peripheral blood was the most reliable procedure. Eighteen of the 20 patients developed lymphomatous disorders 2 to 26 months after the presumptive diagnosis of prelymphoma was made. Follow-up studies have been continued on the remaining two patients. One has persistent leukopenia and the other an unexplained mast-cell infiltration of the marrow.
Tetracycline and Staining of the Teeth
Authors: Elmer R. Grossman
Journal: JAMA (1986)

<h3>To the Editor.—</h3> In their recent article on minocycline staining of already erupted permanent teeth, Poliak et al<sup>1</sup>state that tetracycline stains teeth only when it is administered before the age of 7 years. They go on to speculate that "tetracycline's inability to stain the teeth beyond the age of 7 years may be a function of the unavailability of free calcium for complexing." The first statement is in error and the speculation is unnecessary. Tetracycline will bind to teeth (and to bone) whenever active calcification is taking place.<sup>2</sup>For teeth, this means from the second trimester of fetal life until the roots of the third molars are complete in late adolescence. In terms of clinical significance, tetracycline tooth staining of the usual type is important only for the highly visible anterior teeth (incisors, cuspids, and bicuspids). These teeth complete their crown formation by the age of 6
Body Cavity-Based Malignant Lymphoma Containing Kaposi Sarcoma-Associated Herpesvirus in an HIV-Negative Man with Previous Kaposi Sarcoma
Authors: James A. Strauchen
Journal: Annals of Internal Medicine (1996)

Background: The role of Kaposi sarcoma-associated herpesvirus in the development of malignant lymphomas in patients negative for the human immunodeficiency virus (HIV) has not been established. Objective: To examine the possible role of Kaposi sarcoma-associated herpesvirus in a case of body cavity-based malignant lymphoma that occurred in an HIV-negative patient who had previously had Kaposi sarcoma. Design: Case study. Setting: Academic medical center. Patient: A 94-year-old man with lymphomatous ascites. Measurements: Polymerase chain reaction (PCR) and Southern blot DNA analysis. Results: The body cavity-based lymphoma cells were positive for Kaposi sarcoma-associated herpesvirus by PCR and were negative for other herpesviruses, including Epstein-Barr virus, cytomegalovirus, and human herpesviruses 6 and 7. Southern blot analysis of lymphoma DNA showed high levels of Kaposi sarcoma-associated herpesvirus (>40 to 80 genomes/cell). Clonal rearrangement of the immunoglobulin JH and JK genes was present, confirming the presence of a clonal B-cell proliferation. Conclusions: Kaposi sarcoma-associated herpesvirus may be involved in the development of malignant lymphoma after Kaposi sarcoma in HIV-negative patients. This type of lymphoma, in contrast to body cavity-based lymphoma related to the acquired immunodeficiency syndrome, may have an indolent clinical course.
Indomethacin-Induced Prostaglandin Inhibition with Hyperkalemia
Authors: S. Y. TAN
Journal: Annals of Internal Medicine (1979)

Hyporeninemic hypoaldosteronism was diagnosed in a young woman with glomerulonephritis who was receiving indomethacin therapy. Despite only mildly abnormal renal function, serum K+ was elevated to 6.2 meq/L, and plasma renin activity (0.12 ng/mL h) and aldosterone (4.4 ng/ dL) failed to respond to the combined stimuli of furosemide and posture. Urinary prostaglandin E2 (PGE2) was suppressed (70 ng/24 h). When indomethacin was withdrawn, significant kaliuresis occurred, accompanied by normalization of serum K+ and PGE2 and a supranormal rebound in renin and aldosterone levels. Challenge with indomethacin resulted in antikaliuresis and resuppression of PGE2, renin, and aldosterone. This case study documents for the first time that indomethacin can cause the syndrome of hyporeninemic hypoaldosteronism, probably by inhibiting prostaglandin biosynthesis.
Effects of the nanostructure of dendrimer/DNA complexes on their endocytosis and gene expression
Authors: Shu-Fen Peng, Chun-Jen Su, Ming-Cheng Wei, Chun-Yu Chen, Zi-Xian Liao, Po-Wei Lee, Hsin-Lung Chen, Hsing-Wen Sung
Journal: Biomaterials (2010)
84 PATTERNS OF INTERFERON-INDUCED GENES IN LIVER AND PERIPHERAL BLOOD MONONUCLEAR CELLS (PBMCS) DURING THE FIRST 24 HOUR (PHASE 1) TREATMENT IN HCV GENOTYPE 1 PATIENTS
Authors: D. Lau, M. Sinha, Y. Zhang, E. Shudo, A. Perelson, B. Luxon, S. Lemon, T. Saito, M. Gale
Journal: Journal of Hepatology (2009)
Spectral karyotyping identifies new rearrangements, translocations, and clinical associations in diffuse large B-cell lymphoma
Authors: Gouri Nanjangud, Pulivarthi H. Rao, Abhijith Hegde, Julie Teruya-Feldstein, Gerard Donnelly, Jing Qin, Suresh C. Jhanwar, Andrew D. Zelenetz, R. S. K. Chaganti
Journal: Blood (2002)
Hypoxia modulates the gene expression profile of immunoregulatory receptors in human mature dendritic cells: identification of TREM-1 as a novel hypoxic marker in vitro and in vivo
Authors: Maria Carla Bosco, Daniele Pierobon, Fabiola Blengio, Federica Raggi, Cristina Vanni, Marco Gattorno, Alessandra Eva, Francesco Novelli, Paola Cappello, Mirella Giovarelli, Luigi Varesio
Journal: Blood (2010)
GAO: Better Coordination Needed to Avoid Duplicate Autism Research
Authors: Mike Mitka
Journal: JAMA (2014)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Professionalism vs Commercialism in Managed Care: The Need for a National Council on Medical Care
Authors: Adam Yarmolinsky
Journal: JAMA (1997)

To the Editor.  —While Drs McArthur and Moore1identify the problem of professionalism vs commercialization in managed care, they refuse to consider the only intellectually or morally viable solution. The two cultures that they describe and delineate—commerce and professional care—are not just un-comfortable partners, but rather are essentially incompatible. One cannot really  for another individual if the reason for that caring is commercial. The result will be something, with some kind of commercial value, but it will not be the professional care we all have solemnly agreed to provide.  If what we want, and I believe that it is what we not only want but desperately need, is professional patient-oriented medical care, then it must be separated from the commercial system that has no interest in human problems, of whatever cause or magnitude. Commerce just doesn't care—it cannot afford to do so; medicine does, and never in any inherently logical or
BRAF Inhibition Stimulates Melanoma-Associated Macrophages to Drive Tumor Growth
Authors: Tao Wang, Min Xiao, Yingbin Ge, Clemens Krepler, Eric Belser, Alfonso Lopez-Coral, Xiaowei Xu, Gao Zhang, Rikka Azuma, Qin Liu, Rui Liu, Ling Li, Ravi K. Amaravadi, Wei Xu, Giorgos Karakousis, Tara C. Gangadhar, Lynn M. Schuchter, Melissa Lieu, Sanika Khare, Molly B. Halloran, Meenhard Herlyn, Russel E. Kaufman
Journal: Clinical Cancer Research (2015)

To investigate the roles of melanoma-associated macrophages in melanoma resistance to BRAF inhibitors (BRAFi).An in vitro macrophage and melanoma cell coculture system was used to investigate whether macrophages play a role in melanoma resistance to BRAFi. The effects of macrophages in tumor resistance were examined by proliferation assay, cell death assay, and Western blot analyses. Furthermore, two mouse preclinical models were used to validate whether targeting macrophages can increase the antitumor activity of BRAFi. Finally, the number of macrophages in melanoma tissues was examined by immunohistochemistry.We demonstrate that in BRAF-mutant melanomas, BRAFi paradoxically activate the mitogen-activated protein kinase (MAPK) pathway in macrophages to produce VEGF, which reactivates the MAPK pathway and stimulates cell growth in melanoma cells. Blocking the MAPK pathway or VEGF signaling then reverses macrophage-mediated resistance. Targeting macrophages increases the antitumor activity of BRAFi in mouse and human tumor models. The presence of macrophages in melanomas predicts early relapse after therapy.Our findings demonstrate that macrophages play a critical role in melanoma resistance to BRAFi, suggesting that targeting macrophages will benefit patients with BRAF-mutant melanoma.
Informed (but Uneducated) Consent
Authors: F. J. Ingelfinger
Journal: New England Journal of Medicine (1972)

The trouble with informed consent is that it is not educated consent. Let us assume that the experimental subject, whether a patient, a volunteer, or otherwise enlisted, is exposed to a completely honest array of factual detail. He is told of the medical uncertainty that exists and that must be resolved by research endeavors, of the time and discomfort involved, and of the tiny percentage risk of some serious consequences of the test procedure. He is also reassured of his rights and given a formal, quasilegal statement to read. No exculpatory language is used. With his written signature, the subject . . .
A CASE OF ERYTHEMA SCARLATINIFORME
Authors: F. GARDINER
Journal: British Journal of Dermatology (1908)

Journal Article A CASE OF ERYTHEMA SCARLATINIFORME Get access F. GARDINER, M.D., B.Sc., F.R.C.S.E. F. GARDINER, M.D., B.Sc., F.R.C.S.E. Assistant Physician to the Skin‐Department Edinburgh Royal Infirmary Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 20, Issue 8, 1 August 1908, Pages 245–248, https://doi.org/10.1111/j.1365-2133.1908.tb16575.x Published: 01 August 1908
Women must take control of HIV prevention to curb spread of infection
Authors: Jocalyn Clark
Journal: BMJ (2006)

Until women take control of HIV prevention, it will be impossible to halt the global spread of HIV/AIDS, several speakers claimed at the 16th international AIDS conference in Toronto this week.

Of the 39 million people in the world currently living with HIV or AIDS, half are women. Of the 45 million new cases expected between 2002 and 2010, 70% are likely to be in women in the developing world, says UNAIDS.

Signalling an urgent need to prioritise methods of prevention that take control away from men, while acknowledging the remoteness of an effective HIV vaccine and the soaring costs of treatments, advocates urged greater investment in microbicide research.

Microbicide gels and creams can be applied before sex to prevent HIV and other sexually transmitted viruses from attaching to vaginal walls. Relatively inexpensive and easy to manufacture and distribute, they are designed to be used by women without the cooperation, consent, or knowledge of their partners.

Women's health …
Doctors disagree about directive on European clinical trials
Authors: Rory Watson
Journal: BMJ (2007)

Contradictory details are emerging of the impact that the three year old European Union legislation on clinical trials is having on medical science.

According to research presented on 27 September at a conference in Barcelona organised by the European Cancer Organisation, the number of non-commercial clinical trials has fallen by a quarter. Markus Hartmann, from European Consulting and Contracting in Oncology, Trier, Germany, told participants that this figure was a “conservative estimate.”

But data from the European Medicines Evaluation Agency show that the percentage of non-commercial trials increased between 2005 and 2006. The agency and the European Commission launched consultations at a conference in …
Variants in KCNQ1 are associated with susceptibility to type 2 diabetes mellitus
Authors: Kazuki Yasuda, Kazuaki Miyake, Yukio Horikawa, Kazuo Hara, Haruhiko Osawa, Hiroto Furuta, Yushi Hirota, Hiroyuki Mori, Anna Jonsson, Yoshifumi Sato, Kazuya Yamagata, Yoshinori Hinokio, He-Yao Wang, Toshihito Tanahashi, Naoto Nakamura, Yoshitomo Oka, Naoko Iwasaki, Yasuhiko Iwamoto, Yuichiro Yamada, Yutaka Seino, Hiroshi Maegawa, Atsunori Kashiwagi, Jun Takeda, Eiichi Maeda, Hyoung Doo Shin, Young Min Cho, Kyong Soo Park, Hong Kyu Lee, Maggie C Y Ng, Ronald C W Ma, Wing-Yee So, Juliana C N Chan, Valeriya Lyssenko, Tiinamaija Tuomi, Peter Nilsson, Leif Groop, Naoyuki Kamatani, Akihiro Sekine, Yusuke Nakamura, Ken Yamamoto, Teruhiko Yoshida, Katsushi Tokunaga, Mitsuo Itakura, Hideichi Makino, Kishio Nanjo, Takashi Kadowaki, Masato Kasuga
Journal: Nature Genetics (2008)
Obesity and cardiac function.
Authors: O de Divitiis, S Fazio, M Petitto, G Maddalena, F Contaldo, M Mancini
Journal: Circulation (1981)

We studied 10 obese volunteers, mean age 36.5 +/- 10.3 years, who weighed 123.56 +/- 28.7 g and were 69.96 +/- 22.5 kg overweight. The subjects did not have diabetes, arterial hypertension or signs of cardiac and respiratory failure or disease and all underwent right- and left-heart catheterization. cardiac output and stroke volume were high, according to increased oxygen consumption and to the degree of obesity. Ventricular end-diastolic and atrial pressures ranged from normal to high and correlated with body weight, signs of volume overloading and reduced left ventricular (LV) compliance. The mean pulmonary artery pressure was elevated and correlated well with weight, pulmonary resistance being normal; mean aortic pressure did not correlate with weight, and systemic arterial resistance tended to have a negative correlation. The LV function curve showed impaired ventricular function, particularly for the heaviest subjects, in whom Vmax and the ratio of the stroke work index to LV end-diastolic pressure were reduced. These indexes correlated well with each other and both correlated negatively with the degree of obesity. In contrast, maximal dP/dt was normal and did not correlate with excess weight. These observations show that depressed LV function is already present in relatively young obese people, even if they are free from signs of cardiopathy and other associate diseases. The degree of impairment of heart function seems to parallel the degree of obesity.
Purification of high molecular weight forms of renin from hog kidney.
Authors: T Inagami, K Murakami
Journal: Circulation Research (1977)

To elucidate the possible regulatory function of high molecular weight renins in blood pressure control, studies were initiated to purify and characterize the high molecular weight enzyme. To avoid the destructive effect of acidification during affinity chromatographic elution, pepstatin-aminobutyl-agarose gel was used from which renin could be eluted at a neutral pH in 2 M urea. Three additional steps of conventional chromatography after the affinity technique produced two types of high molecular weight renins in electrophoretically homogeneous forms. Big renin with a molecular weight of 61,000 has a specific activity approximately 20% of the fully active small molecular weight renin (mol wt 40,000). Big big renins with molecular weights of 140,000 were discovered and purified in two homogeneous forms with specific activities less than 1% of the fully active renin. The possibility of zymogen-enzyme relationship involving the big big, the big, and the fully small molecular weight renins is discussed.