OBSERVATIONS ON THE ABSORPTION, EXCRETION AND DISTRIBUTION OF SULFANILAMIDE, SULFAPYRIDINE, SULFATHIAZOLE AND SULFAMETHYLTHIAZOLE
Authors: Elias Strauss, Francis C. Lowell, F. H. Laskey Taylor, Maxwell Finland
Journal: Annals of Internal Medicine (1941)

Article1 February 1941OBSERVATIONS ON THE ABSORPTION, EXCRETION AND DISTRIBUTION OF SULFANILAMIDE, SULFAPYRIDINE, SULFATHIAZOLE AND SULFAMETHYLTHIAZOLEELIAS STRAUSS, FRANCIS C. LOWELL, F. H. LASKEY TAYLOR, MAXWELL FINLAND, F.A.C.P.ELIAS STRAUSSSearch for more papers by this author, FRANCIS C. LOWELLSearch for more papers by this author, F. H. LASKEY TAYLORSearch for more papers by this author, MAXWELL FINLAND, F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-14-8-1360 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptIn a previous paper,1Taylor and his associates reported the results of studies on the absorption and excretion of sulfanilamide and sulfapyridine after administration of a single dose by various routes. Special consideration was given in that paper to a glucose-sulfapyridine solution which was shown to be absorbed, excreted and distributed in the body in a manner radically different from that of either sulfapyridine or sulfanilamide. The present paper deals with a continuation of these studies with particular reference to sulfathiazole and sulfamethylthiazole. We include also the results of studies of (1) the absorption and urinary excretion of the sodium...Bibliography1. TAYLORLOWELLADAMSSPRINGFINLAND FHFCMAWCM: A comparative study of the blood concentrations and urinary excretion of sulfapyridine and sulfanilamide after single doses of sulfapyridine and related compounds administered by various routes, Jr. Clin. Invest., 1940, xix, 201. CrossrefGoogle Scholar2. BRATTONMARSHALL ACEK: A new coupling component for sulfanilamide determination, Jr. Biol. Chem., 1939, cxxviii, 537. CrossrefGoogle Scholar3. STEWARTROURKEALLEN JDGMJG: Excretion of sulfanilamide, Jr. Am. Med. 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MARSHALLEMERSONCUTTING EKKWC: The distribution of sulfanilamide in the organism, Jr. Pharmacol. and Exper. Therap., 1937, lxi, 196. Google Scholar20. CHINNBELLOWS HJ: The distribution of sulfanilyl-2-aminopyridine in the body, Jr. Lab. and Clin. Med., 1940, xxv, 735. Google Scholar21. MARSHALLLITCHFIELD EKJT: Some aspects of the pharmacology of sulfapyridine, Jr. Pharmacol. and Exper. Therap., 1939, lxvii, 454. Google Scholar22. BETTMANSPIER RE: Concentration of sulfanilamide in human bile, Proc. Soc. Exper. Biol. and Med., 1939, xli, 463. CrossrefGoogle Scholar23. STEWARTROURKEALLEN JDGMJG: Acetylation of sulfanilamide, Surgery, 1939, v, 232. Google Scholar24. CAREY BW: Use of sulfanilamide and related compounds in diseases of infancy and childhood, Jr. Am. Med. Assoc., 1940, cxv, 929. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Boston, Massachusetts*Received for publication October 16, 1940.From the Thorndike Memorial Laboratory, Second and Fourth Medical Services (Harvard), Boston City Hospital, and the Department of Medicine, Harvard Medical School, Boston.We are indebted to Elizabeth Shaler Smith, Louise Sheldon and Margaret A. Adams for technical assistance in carrying out the chemical determinations. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byON THE ABSORPTION OF SULFONES TO RED BLOOD CELLSBarreira hemoencefálicaKlinische Ergebnisse der Chemotherapie durch SulfonamideBibliographyDiseases of anorectum and colon review of certain recent contributionsPNEUMONIA TREATED WITH SULPHA- PYRIDINE AND SULPHATHIAZOLE CONCENTRATION OF THE DRUGS IN THE BLOODSulfathiazol and sulfamethylthiazol in the treatment of pneumonia 1 February 1941Volume 14, Issue 8Page: 1360-1382KeywordsExcretionHospital medicineMedical servicesResearch laboratoriesSodium ePublished: 1 December 2008 Issue Published: 1 February 1941 PDF downloadLoading ...