tbuckley/cabot-search huggingface dataset:
Adult Chalasia. The Incompetent Gastroesophageal Sphincter and Reflux Esophagitis.
Authors: Jean K. Haddad
Journal: Annals of Internal Medicine (1970)

Meeting Abstracts1 May 1970Adult Chalasia. The Incompetent Gastroesophageal Sphincter and Reflux Esophagitis.Jean K. Haddad, M.D. (Associate), Marvin H. Sleisenger, M.D., F.A.C.P.Jean K. Haddad, M.D. (Associate)Search for more papers by this author, Marvin H. Sleisenger, M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-72-5-792_2 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptFifteen male patients with gastroesophageal reflux but without a radiographically demonstrable hiatal hernia (chalasia) were studied by esophageal motility; their gastroesophageal sphincter pressures were compared to those of 15 healthy men without reflux. Manometric studies were perfoxrmed with constant catheter perfusion and intraluminal pH monitoring. Reflux of barium at time of upper gastrointestinal radiography was seen in only two of the chalasia group and in none of the controls. A hiatal hernia was not demonstrated in any of the 30 patients, either radiographically or manometrically. Many in the chalasia group had been symptomatic for long periods of time and had... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: Jean K. Haddad, M.D. (Associate); Marvin H. Sleisenger, M.D., F.A.C.P.Affiliations: San Francisco, Calif. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byReproducibility of Gastroesophageal Reflux Scintigraphy and the Standard Acid Reflux TestScintigraphy, Ph Measurement, and Radiography in the Evaluation of Gastroesophageal Reflux 1 May 1970Volume 72, Issue 5Page: 792-792KeywordsCathetersDiagnostic radiologyGastroenterology and hepatologyGastroesophageal reflux diseaseHernia ePublished: 1 December 2008 Issue Published: 1 May 1970 PDF downloadLoading ...
Where have all the students gone? An epidemiologic study of US nationals applying for certification by the Educational Commission for Foreign Medical Graduates, 1969 through 1982
Authors: T. D. Dublin
Journal: JAMA (1985)

Larger and larger numbers of US nationals are studying medicine abroad and they now comprise the foremost national group of foreign medical graduates (FMGs) seeking to enter the US health care system. The Educational Commission for Foreign Medical Graduates (ECFMG) is currently conducting a comprehensive study of 205,542 graduates of foreign medical schools who, during a 14-year study period, 1969 through 1982, have sought its certification, an established prerequisite for FMGs applying for training in an accredited hospital residency program and/or licensure within the United States. This report summarizes preliminary data on the 17,642 US citizens included in the study who attended 431 different medical schools in 79 foreign countries. Particular attention is given to their performance on the combined medical knowledge-English language competence examinations requisite to the awarding of ECFMG certification.
A Warning Not Heeded.
Authors: Arthur C. Bell
Journal: JAMA (1907)

Dallas, Texas, Nov. 12, 1907. <h3>To the Editor:</h3> —From the fact that there is in Texas a huge conspiracy against all young medical school I hereby warn you not to mention in any of your publications including the A. M. A.Journalany unfavorable mention of the College of Phys. &amp; Surg., Dallas. Kindly refuse to mention this school in any till further notice. I warn you under penalty of the law. [See page 1795, item headed "Texas Board Withdraws Recognition."—Ed.]
INSULIN REACTION AND RECOVERY IN DIABETIC PATIENT
Authors: Marios C. Balodimos
Journal: JAMA (1960)

A case of severe insulin reaction resulting in unconsciousness of 60 hours' duration was caused in a young diabetic woman by the erroneous administration of 1,800 units of insulin. Early recognition of the hypoglycemia and intensive treatment were responsible for the patient's complete recovery.  The patient, a 16-year-old, overweight girl, was brought to the emergency room on Jan. 3, 1956, after having been unconscious for the preceding three hours. This was her 14th hospital admission. She had been a known diabetic since 1948, taking about 100 units of insulin daily. Her previous admissions had been primarily for diabetic acidosis and coma, of which she had a total of 11 episodes in 1955 alone. The patient was dehydrated and restless and responded little to external stimuli. Her face was flushed, temperature was 100.0 F (37.7 C), and pulse rate was 120 per minute. She did not have Kussmaul's respiration. The urine
The Evolving Look and Vision of<i>JAMA Pediatrics</i>
Authors: Frederick P. Rivara
Journal: JAMA Pediatrics (2013)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Pediatrics HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Pediatrics journal
Endoscopic retrieval of a proximally migrated pancreatic stent: variation of the lasso technique
Authors: J. Vila, D. Ruiz-Clavijo, I. Fernández-Urién, A. Martínez, M. Kutz, I. Elizalde, J. Zozaya
Journal: Endoscopy (2010)

Many devices have proved to be useful to retrieve proximally migrated pancreatic stents [1] [2]. The lasso technique involves inserting a guide wire through the lumen of the migrated stent followed by insertion of a partially opened polypectomy snare over the wire to grasp the stent [3].
Hepatic Decompensation in Antiretroviral-Treated Patients Co-Infected With HIV and Hepatitis C Virus Compared With Hepatitis C Virus–Monoinfected Patients
Authors: Vincent Lo Re, Michael J. Kallan, Janet P. Tate, A. Russell Localio, Joseph K. Lim, Matthew Bidwell Goetz, Marina B. Klein, David Rimland, Maria C. Rodriguez-Barradas, Adeel A. Butt, Cynthia L. Gibert, Sheldon T. Brown, Lesley Park, Robert Dubrow, K. Rajender Reddy, Jay R. Kostman, Brian L. Strom, Amy C. Justice
Journal: Annals of Internal Medicine (2014)

Background: The incidence and determinants of hepatic decompensation have been incompletely examined among patients co-infected with HIV and hepatitis C virus (HCV) in the antiretroviral therapy (ART) era, and few studies have compared outcome rates with those of patients with chronic HCV alone. Objective: To compare the incidence of hepatic decompensation between antiretroviral-treated patients co-infected with HIV and HCV and HCV-monoinfected patients and to evaluate factors associated with decompensation among co-infected patients receiving ART. Design: Retrospective cohort study. Setting: Veterans Health Administration. Patients: 4280 co-infected patients who initiated ART and 6079 HCV-monoinfected patients receiving care between 1997 and 2010. All patients had detectable HCV RNA and were HCV treatment–naive. Measurements: Incident hepatic decompensation, determined by diagnoses of ascites, spontaneous bacterial peritonitis, or esophageal variceal hemorrhage. Results: The incidence of hepatic decompensation was greater among co-infected than monoinfected patients (7.4% vs. 4.8% at 10 years; P < 0.001). Compared with HCV-monoinfected patients, co-infected patients had a higher rate of hepatic decompensation (hazard ratio [HR] accounting for competing risks, 1.56 [95% CI, 1.31 to 1.86]). Co-infected patients who maintained HIV RNA levels less than 1000 copies/mL still had higher rates of decompensation than HCV-monoinfected patients (HR, 1.44 [CI, 1.05 to 1.99]). Baseline advanced hepatic fibrosis (FIB-4 score >3.25) (HR, 5.45 [CI, 3.79 to 7.84]), baseline hemoglobin level less than 100 g/L (HR, 2.24 [CI, 1.20 to 4.20]), diabetes mellitus (HR, 1.88 [CI, 1.38 to 2.56]), and nonblack race (HR, 2.12 [CI, 1.65 to 2.72]) were each associated with higher rates of decompensation among co-infected patients. Limitation: Observational study of predominantly male patients. Conclusion: Despite receiving ART, patients co-infected with HIV and HCV had higher rates of hepatic decompensation than HCV-monoinfected patients. Rates of decompensation were higher for co-infected patients with advanced liver fibrosis, severe anemia, diabetes, and nonblack race. Primary Funding Source: National Institutes of Health.
A Randomized Double-blind Placebo-controlled Phase 2 Dose-ranging Study of OnabotulinumtoxinA in Men with Benign Prostatic Hyperplasia
Authors: Michael Marberger, Emmanuel Chartier-Kastler, Blair Egerdie, Kyu-Sung Lee, Joachim Grosse, Denise Bugarin, Jihao Zhou, Anand Patel, Cornelia Haag-Molkenteller
Journal: European Urology (2012)
ELECTROLYTE AND FLUID STUDIES DURING WATER DEPRIVATION AND STARVATION IN HUMAN SUBJECTS, AND THE EFFECT OF INGESTION OF FISH, OF CARBOHYDRATE, AND OF SALT SOLUTIONS 12
Authors: A. W. Winkler, T. S. Danowski, J. R. Elkinton, J. P. Peters
Journal: Journal of Clinical Investigation (1944)

Human volunteers were deprived partially, or completely, of water and food for several days.Balances of water, of nitrogen, and of various electrolytes were measured, together with the concentrations of these same substances in serum.From these data, the partition of the total water loss between extracellular and intracellular phases was estimated.3The possible therapeutic val- ues of water, various salt solutions, carbo- hydrate, and whole fish were assayed in certain experiments. CHEMICAL METHODSSamples of serum and defibrinated whole venous blood were collected anaerobically.Concentrations of sodium, potassium, and chloride in serum were determined by the methods of Hald (1, 2).Carbon dioxide content of serum or plasma was measured by the method of Van Slyke and Neill (3), heparinized plasma equilibrated with carbon dioxide at a partial pressure of 40 mm.Hg being used in Ex- periment I. Total and non-protein nitrogen of serum and I Lt. Col. D. B.
Hepatic gene expression in histologically progressive nonalcoholic steatohepatitis
Authors: Raghavakaimal Sreekumar, Barbara Rosado, Deborah Rasmussen, Michael Charlton
Journal: Hepatology (2003)

Although the molecular basis for the pathophysiology of nonalcoholic steatohepatitis (NASH) is poorly understood, insulin resistance and mitochondrial dysfunction are physiologic hallmarks of this condition. We sought evidence of a transcriptional or pretranscriptional basis for insulin resistance and mitochondrial dysfunction through measurement of hepatic gene expression (messenger RNA [mRNA]) using high–density synthetic oligonucleotide microarray analysis (Hu6800 GeneChip, Affymetrix, CA). Global hepatic gene expression was determined in snap–frozen liver biopsy specimens from 4 groups: (1) patients with cirrhotic–stage NASH (n = 6), (2) patients with cirrhosis caused by hepatitis C virus (HCV) (n = 6), (3) patients with cirrhosis secondary to primary biliary cirrhosis (PBC) (n = 6), and (4) healthy controls (n = 6). Genes were considered to be expressed differentially in NASH only if there was a greater than 2–fold difference in abundance of mRNA when compared with each of the control groups. Sixteen genes were uniquely differentially expressed (4 overexpressed and 12 underexpressed) in patients with cirrhotic–stage NASH. Genes that were significantly underexpressed included genes important for maintaining mitochondrial function (copper/zinc superoxide dismutase, aldehyde oxidase, and catalase). Glucose 6–phospatase, alcohol dehydrogenase, elongation factor–TU, methylglutaryl coenzyme A (CoA), acyl CoA synthetase, oxoacyl CoA thiolase, and ubiquitin also were underexpressed in NASH. Genes that were overexpressed in NASH included complement component C3 and hepatocyte–derived fibrinogen–related protein, potentially contributing to impaired insulin sensitivity. In conclusion, these studies provide evidence for a transcriptional or pretranscriptional basis for impaired mitochondrial function (attenuated capacity for the dismutation of reactive oxygen species) and diminished insulin sensitivity (increased acute phase reactants) in patients with histologically progressive NASH. Further studies are required to determine the mechanism and the physiologic significance of these findings.
Electrophysiological abnormalities and arrhythmias in alpha MHC mutant familial hypertrophic cardiomyopathy mice.
Authors: C I Berul, M E Christe, M J Aronovitz, C E Seidman, J G Seidman, M E Mendelsohn
Journal: Journal of Clinical Investigation (1997)

A new mouse cardiac electrophysiology method was used to study mice harboring an alpha-myosin heavy chain Arg403Gln missense mutation (alpha-MHC403/+), which results in histological and hemodynamic abnormalities characteristic of familial hypertrophic cardiomyopathy (FHC) and sudden death of uncertain etiology during exercise. Wild-type animals had completely normal cardiac electrophysiology. In contrast, FHC mice demonstrated (a) electrocardiographic abnormalities including prolonged repolarization intervals and rightward axis; (b) electrophysiological abnormalities including heterogeneous ventricular conduction properties and prolonged sinus node recovery time; and (c) inducible ventricular ectopy. These data identify distinct electrophysiologic abnormalities in FHC mice with a specific alpha-myosin mutation, and also validate a novel method to explore in vivo the relationship between specific genotypes and their electrophysiologic phenotypes.
Henry Tubbs Ricketts, 1901-1979
Authors: William R. Barclay
Journal: JAMA (1980)

Medicine lost a distinguished physician and I a valued friend and colleague with the death of Henry T. Ricketts, MD, on Nov 23, 1979. Henry was born in Berlin on Aug 11, 1901, of American parents. He graduated with a BS degree from the University of Chicago in 1924 and then transferred to Harvard, where he obtained the MD degree in 1929. In 1933 he returned to the University of Chicago School of Medicine as an instructor. At that time, this was a new school built as an integral part of the university, complete with a teaching hospital on the university campus. The school had a brand-new philosophy of medical education: All clinical teachers were full-time salaried university faculty and functioned as did teachers in all other faculties in the university. It was a splendid and exciting environment, which Henry entered, that encouraged research and the practice of medicine as
Changes in liver fibrosis at the end of alpha interferon therapy and 6 to 18 months later in patients with chronic hepatitis C: quantitative assessment by a morphometric method
Authors: Veronique Duchatelle, Patrick Marcellin, Emile Giostra, Laurence Bregeaud, Michele Pouteau, Nathalie Boyer, Anne Auperin, Sylviane Guerret, Serge Erlinger, Dominique Henin, Claude Degott
Journal: Journal of Hepatology (1998)
Helicobacter pylori Susceptibility in the GWAS Era
Authors: Emad M. El-Omar
Journal: JAMA (2013)

Helicobacter pylori infection remains one of the most common chronic bacterial infections worldwide and is causally linked to the pathogenesis of peptic ulcer disease, gastric adenocarcinoma, and MALT (mucosa-associated lymphoid tissue) lymphoma.1 However, the majority of infected patients generally remain asymptomatic and never develop significant disease. Because of its wide prevalence and causal association with serious disease outcomes, this infection has deservedly commanded the attention and dedication of researchers across the globe.
Progressive neurological dysfunction during latent HIV infection.
Authors: J. Jakobsen, T. Smith, J. Gaub, S. Helweg-Larsen, W. Trojaborg
Journal: BMJ (1989)

OBJECTIVE--To determine whether the delayed conduction through the spinal cord and peripheral nerves seen in patients with AIDS is related to infection with HIV or to the presence of an immunodeficient state. DESIGN--Two year prospective follow up study of electrophysiological measurements in subjects positive for HIV antibody but without AIDS. SETTING--HIV screening clinic and clinical departments in a university hospital in Copenhagen, Denmark. SUBJECTS--Twelve homosexual men positive for HIV antibody who had not developed AIDS. RESULTS--Eight latencies were measured: from the ankle to T12, the wrist to C7, T12 to the cerebral cortex, C7 to the cerebral cortex, the ankle to the gluteal crease (tibial nerve), the gluteal crease to T12, the wrist to Erb's point (median nerve), and Erb's point to C7. Spinal latencies increased in all subjects at C7 by a mean of 4.2% (SE 0.9%) and in all except one at T12 by a mean of 5.5% (1.0%). The conduction time from the gluteal crease to T12 was increased by a mean of 32.0% (5.0%) whereas that in the median and tibial nerves by only 5.6% (1.0%) and 2.2% (2.2%) respectively. CONCLUSIONS--A mild and slowly progressive peripheral neuropathy of the axonal type and a more severe progressive myelopathy or myeloradiculopathy occur concomitantly with early HIV infection, possibly as the result of a direct neurotropic action of HIV.
Opioid Pain Medication Use After Dermatologic Surgery
Authors: KaLynne Harris, Julia Curtis, Brooke Larsen, Scott Calder, Keith Duffy, Glen Bowen, Michael Hadley, Payam Tristani-Firouzi
Journal: JAMA Dermatology (2012)

To better understand postoperative opioid use after dermatologic surgery.Prospective observational study.Academic dermatology department.The study included 212 adults (1) who were undergoing a single skin excision (including Mohs micrographic surgery), (2) who consented to participate,and (3) who were able to be reached by telephone on postoperative day 3 or 4. Patients who did not meet these criteria and those referred to another physician for further surgical treatment or repair were excluded.The study examined(1) the incidence of opioid prescription after dermatologic surgery, (2) the percentage of prescribed opioid pain medications used in the postoperative period, and (3) patient and surgical characteristics associated with opioid pain medication prescription and use.Opioids were prescribed to 72 of the 212 patients(34%). Twenty-five of the 72 patients (35%) who were prescribed opioids did not use them. Forty-nine of 57 patients (86%) who filled an opioid prescription had leftover pills, and 26 of the 49 patients (53%) planned to keep them. Only maximum pain score was significantly associated with opioid use.Opioids were over prescribed after dermatologic surgery. Patients who had left over opioids did not dispose of them properly, which could lead to potential misuse and abuse.
High-Trauma Fractures and Low Bone Mineral Density in Older Women and Men
Authors: Dawn C. Mackey
Journal: JAMA (2007)

ContextIt is widely believed that fractures resulting from high trauma are not osteoporotic; however, this assumption has not been studied prospectively.Objective To examine the association between bone mineral density (BMD) and hightrauma fracture and between high-trauma fracture and subsequent fracture in older women and men.Design, Setting, and Participants Two prospective US cohort studies in communitydwelling adults 65 years or older from geographically diverse sites.The Study of Osteoporotic Fractures followed up 8022 women for 9.1 years (1988-2006).The Osteoporotic Fractures in Men Study followed up 5995 men for 5.1 years (2000-2007). Main Outcome MeasuresHip and spine BMD were assessed by dual-energy x-ray absorptiometry.Incident nonspine fractures were confirmed by radiographic report.Fractures were classified, without knowledge of BMD, as high trauma (due to motor vehicle crashes and falls from greater than standing height) or as low trauma (due to falls from standing height and less severe trauma). ResultsOverall, 264 women and 94 men sustained an initial high-trauma fracture and 3211 women and 346 men sustained an initial low-trauma fracture.For women, each 1-SD reduction in total hip BMD was similarly associated with an increased risk of high-trauma fracture (multivariate relative hazard [RH], 1.45; 95% confidence interval [CI], 1.23-1.72)and low-trauma fracture (RH, 1.49; 95% CI, 1.42-1.57).Results were consistent in men (high-trauma fracture RH, 1.54; 95% CI, 1.20-1.96;low-trauma fracture RH, 1.69; 95% CI, 1.49-1.91).Risk of subsequent fracture was 34% (95% CI, 7%-67%) greater among women with an initial high-trauma fracture and 31% (95% CI, 20%-43%) greater among women with an initial low-trauma fracture, compared with women having no high-or lowtrauma fracture, respectively.Risk of subsequent fracture was not modeled for men.Conclusions Similar to low-trauma nonspine fractures, high-trauma nonspine fractures are associated with low BMD and increased risk of subsequent fracture in older adults.High-trauma nonspine fractures should be included as outcomes in osteoporosis trials and observational studies.
Is hepatoerythropoietic porphyria a homozygous form of porphyria cutanea tarda Inheritance of uroporphyrinogen decarboxylase deficiency in a Spanish family
Authors: P. LAZARO, R.E. SALAMANCA, G.H. ELDER, M.L. VILLASECA, S. CHINARRO, G. JAQUETI
Journal: British Journal of Dermatology (2006)

A patient with hepatoerythropoietic porphyria (HEP) is described. He was shown by a family study to be homozygous for a gene that causes greater than 95% suppression of erythrocyte uroporphyrinogen decarboxylase activity.
DIFFUSE THINNING OF HAIR IN IODIDE-INDUCED HYPOTHYROIDISM
Authors: R. S. CHAPMAN, R. A. MAIN
Journal: British Journal of Dermatology (1967)

Journal Article DIFFUSE THINNING OF HAIR IN IODIDE‐INDUCED HYPOTHYROIDISM Get access R. S. CHAPMAN, M.B., M.R.C.P., Ed., R. S. CHAPMAN, M.B., M.R.C.P., Ed. Registrar in Dermatology Search for other works by this author on: Oxford Academic Google Scholar R. A. MAIN, M.B., M.R.C.P., Ed. R. A. MAIN, M.B., M.R.C.P., Ed. Registrar in Dermatology Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 79, Issue 2, 1 February 1967, Pages 103–105, https://doi.org/10.1111/j.1365-2133.1967.tb11464.x Published: 01 February 1967
SYSTEMIC LUPUS ERYTHEMATOSUS AND NEOPLASIA OF THE LYMPHORETICULAR SYSTEM
Authors: V. C. ANDEEEV, N. B. ZLATKOV
Journal: British Journal of Dermatology (1968)

SUMMARY. Two patients are reported with clinically and immunologically typical systemic lupus erythematosus (SLE). Both subsequently developed neoplastic disorders of the lymphoreticular system—lymphatic leukaemia and Hodgkin's disease. In both patients the LE phenomenon and antinuclear antibody tests were initially positive but became negative as the lymphoma developed. Forty control patients with lymphomas, metastasizing carcinoma or sarcoidosis were submitted to similar immunological investigations. The LE phenomenon was positive in only 2. The possible relationship between SLE and lymphomas and other so‐called immunoproliferative disorders is discussed. The relatively frequent occurrence of immunological abnormalities in the reticu‐loses iand the occasional instances of an apparent transition from SLE to a reticu‐losis lend some support to such an hypothesis, but there may be other explanations for these phenomena. We wish merely to record our findings and to emphasize the importance of intensive investigation of the possible relationship between SLE and immunoproliferative disorders.