tbuckley/cabot-search huggingface dataset:
EMBOLISM AND THROMBOSIS OF THE POPLITEAL ARTERY—DIAGNOSIS AND TREATMENT
Authors: Joseph C. Doane
Journal: Annals of Internal Medicine (1943)

Article1 October 1943EMBOLISM AND THROMBOSIS OF THE POPLITEAL ARTERY—DIAGNOSIS AND TREATMENTJOSEPH C. DOANE, M.D., F.A.C.P.JOSEPH C. DOANE, M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-19-4-634 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe basis of this report will be the presentation of a series of rather typical cases in which occlusion by embolism or thrombosis of the popliteal artery had taken place. Of the 11 cases presented, eight were from the service of the writer and the remaining three were from those of his colleagues. In these 11 patients obstruction of the popliteal had occurred 14 times.Thrombosis and embolism of the popliteal artery are among the commoner arterial accidents. McKechnie and Allen,1in analyzing 100 cases of arterial obstruction found that the popliteal was embolized and/or thrombosed in 44 per cent...Bibliography1. MCKECHNIEALLEN REEV: Sudden occlusion of arteries of the extremities, 100 cases of embolism or thrombosis, Surg., Gynec. and Obst., 1936, lxiii, 231-234. Google Scholar2. SEIFERT E: Die Deutung des Schmerzes bei der arteriellen Embolie, Deutsch. Ztschr. f. Chir., 1931, ccxxxii, 187-198. CrossrefGoogle Scholar3. LEWIS T: Vascular disorders of the limbs, 1936, Macmillan Co., New York N. Y., p. 29. Google Scholar4. GOSSETTBERTRANDPATEL AIJ: Sur la physio-pathologie des embolies arterielles des membres, Ann. d'anat. path., méd.-chir., 1932, ix, 841-862. Google Scholar5. HINDMARSHSANDBERG JI: Forty-five embolectomies (Retrospective survey with special regard to after effects), Acta chir. Scandin., 1936, lxxviii, 81-91. Google Scholar6. DETAKATS D: Vascular accidents of the extremities, Jr. Am. Med. Assoc., 1938, cx, 1075-1081. CrossrefGoogle Scholar7. DENK W: Zur Behandlung der arteriellen Embolie, München. med. Wchnschr., 1934, lxxxi, 437-439. Google Scholar8. HERMANREID LGMR: Passive vascular exercise treatment of peripheral obliterative arterial disease by rhythmic alterations of environmental pressure, Arch. Surg., 1934, xxix, 697-704. CrossrefGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Philadelphia, Pennsylvania*Received for publication May 29, 1942.From the Medical Service of the Jewish Hospital. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 October 1943Volume 19, Issue 4Page: 634-641KeywordsArteriesHeparinMedical servicesPatientsThrombosis ePublished: 1 December 2008 Issue Published: 1 October 1943 PDF downloadLoading ...
Esophageal Motility in Infants and Children
Authors: J D GRYBOSKI, W R THAYER, H M SPIRO
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Abstract 5131: Cadmium induces cytotoxicity in human bronchial epithelial cell in a p53-independent, nuclear factor NF-kappaB-dependent manner
Authors: Ji-Ying Du, De-Ju Chen, Yan-Ming Xu, Andy T. Y. Lau
Journal: Cancer Research (2014)

Abstract Cadmium (Cd) and Cd compounds are widely-distributed in the environment and well known carcinogens. Here, we report that in CdCl2-exposed human bronchial epithelial cells (BEAS-2B), the level of p53 is dramatically decreased in a time- and dose-dependent manner, suggesting that the observed Cd-induced cytotoxicity is not likely due to the pro-apoptotic function of p53. Therefore, this prompted us to further study the responsive pro-apoptotic factors by proteomic approaches. Interestingly, we identified that high levels (20 or 30 μM) of Cd can up-regulate the protein levels of eukaryotic translation initiation factor 5A-1 (eIF-5A-1) and redox-sensitive transcription factor NF-κB p65 in a time- and dose-dependent manner. Moreover, there is an enhanced NF-κB nuclear translocation as well as chromatin-binding in Cd-treated BEAS-2B cells. We also show that small interfering RNA-specific knockdown of eIF-5A-1 in Cd-exposed cells attenuated the Cd cytotoxicity, indicating the potential role of eIF-5A-1 in Cd cytotoxicity. As eIF-5A-1 is reported to be related with cell apoptosis but little is known about its transcriptional control, we hypothesize that NF-κB might likely modulate eIF-5A-1 gene expression. Notably, by bioinformatic analysis, several potential NF-κB binding sites on the upstream promoter region of eIF-5A-1 gene can be found. Subsequent chromatin immunoprecipitation assay revealed that indeed there is enhanced NF-κB binding on eIF-5A-1 promoter region of Cd-treated cells. Taken together, our findings report for the first time a regulatory mechanism for the pro-apoptotic protein eIF-5A-1 in which its level is controlled in an NF-κB-dependent manner. Citation Format: Ji-Ying Du, De-Ju Chen, Yan-Ming Xu, Andy T. Y. Lau. Cadmium induces cytotoxicity in human bronchial epithelial cell in a p53-independent, nuclear factor NF-kappaB-dependent manner. [abstract]. In: Proceedings of the 105th Annual Meeting of the American Association for Cancer Research; 2014 Apr 5-9; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2014;74(19 Suppl):Abstract nr 5131. doi:10.1158/1538-7445.AM2014-5131
Abstract 2658: GPEx® system to increase production of pritumumab in a CHO cell line
Authors: Gregory T. Bleck, Rishab K. Gupta, Beatrix Kotlan, Dona York, Mark C. Glassy
Journal: Cancer Research (2014)

Abstract Pritumumab, a natural human IgG1 kappa antibody isolated from a lymph node of a patient with cervical carcinoma, has been used in a Phase II setting with brain cancer patients. The original human-human hybridoma secreted approximately 1 picogram of antibody per cell per day. This level of the antibody production posed cost constrains for late stage therapeutic clinical trials. To generate a more commercially viable antibody, a pritumumab-secreting Chinese hamster ovary (CHO) cell line was created using the GPEx® technology. This technology involved construction and cloning of heavy and light chain DNA. Both DNA sequences were cloned into the expression vector and transduced into HEK 293 cells that constitutively produces the MLV gag, pro, and pol. The pritumumab cell line was made by performing multiple rounds of transduction (multiplicity of &amp;gt; 1000 retrovector particles/cell) of the GPEx® Chinese Hamster Ovary (GCHO) parental cell line with retrovector made from the gene construct developed to express the pritumumab antibody light chain (LC) and the pritumumab antibody heavy chain (HC). Five independent transductions were performed: two LC and three HC. Limiting dilution method was used to establish clonal cell lines. Top clones were selected based on pritumumab antibody titer. Pritumumab expression was determined by Protein A HPLC using a generic IgG standard. Clearly, single copies of genes were inserted efficiently in unique locations throughout the genome of the CHO cells to obtain genetically stable cell line that expressed high levels of the antibody, and represented more than a 40-fold increase in production of the antibody over the original hybridoma. Flow cytometry binding and immunohistological analyses demonstrated comparability between the recombinant form of pritumumab and the hybridoma form of the protein. Thus, high level of specific productivities and titers of the CHO clones developed through the GPEx® system will allow the therapeutic antibody program to move forward into large and extended clinical trials. Citation Format: Gregory T. Bleck, Rishab K. Gupta, Beatrix Kotlan, Dona York, Mark C. Glassy. GPEx® system to increase production of pritumumab in a CHO cell line. [abstract]. In: Proceedings of the 105th Annual Meeting of the American Association for Cancer Research; 2014 Apr 5-9; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2014;74(19 Suppl):Abstract nr 2658. doi:10.1158/1538-7445.AM2014-2658
Sex differences in high density lipoprotein cholesterol among low-level alcohol consumers.
Authors: G Weidner, S L Connor, M A Chesney, J W Burns, W E Connor, J D Matarazzo, N R Mendell
Journal: Circulation (1991)

The purpose of this study was to examine high density lipoprotein cholesterol (HDL-C) levels in a sample of community-living women and men who consumed 1 drink of alcohol/day or less. Self-reports of alcohol consumption and clinical assessments of plasma lipid and lipoprotein levels were obtained twice, at 12 months apart. Among men, consumption of 1 drink/day or less was unrelated to levels in HDL-C. In contrast, among women alcohol consumption throughout this relatively low consumption range was positively associated with HDL-C levels. These findings indicate that the association of alcohol and higher levels of HDL-C may occur at lower intakes of alcohol in women than in men.
Abstract 302: Vitamin D Deficiency Is Associated with Poor Neurological Outcome After Sudden Cardiac Arrest
Authors: Jin Wi, JaeSun Uhm, Boyoung Joung, Hui-Nam Pak, Moon-Hyoung Lee
Journal: Circulation (2014)

Background:  Vitamin D deficiency has been reported to be related to various cardiovascular diseases, including sudden cardiac arrest (SCA). This study investigated the association of vitamin D deficiency with neurologic outcome after SCA.   Methods:  We prospectively analyzed clinical data from all unconscious patients resuscitated from a SCA of presumed cardiac cause. Neurologic outcome was assessed by Cerebral Performance Category (CPC) score at 6 months after discharge. Good neurologic outcome was defined as CPC score of 1 or 2, whereas poor one as CPC scores of 3 through 5. Vitamin D deficiency was defined as 25(OH)D    Results:  A total of 65 patients [51 men (79%), mean age 59 ± 14 years] were included from May 2012 to October 2013 in this study. First monitored rhythm was shockable rhythm, including ventricular fibrillation or tachycardia, in 44 (68%) and non-shockable rhythm, including pulseless electrical activity or asystole, in 21 (32%). Bystander cardiopulmonary resuscitation (CPR) was performed in 51 (79%) and mean arrest time and CPR time were 26 ± 20 min and 22 ± 18 min, respectively. The mean vitamin D level was 10.5 ± 5.3 ng/mL and vitamin D deficiency was observed in 39 (60%) patients. Vitamin D level was significantly lower among patients with poor neurologic outcome than in those with good outcome (8.0 ± 3.8 vs. 12.1 ± 5.6 ng/mL, p=0.001). Patients with vitamin D deficiency were likely to have more poor neurologic outcome (59 vs. 18%, p=0.001) and mortality (28 vs. 0%, p=0.002). In multivariate logistic analysis, vitamin D deficiency (OR 6.72, 95% CI 2.03-22.26, p=0.002) was the significant independent predictor of poor neurologic outcome after SCA with absence of bystander CPR, first monitored non-shockable rhythm, and baseline renal dysfunction.   Conclusion:  Vitamin D deficiency is the important independent predictor of poor neurologic outcome following SCA.
Psoralen-ultraviolet A-induced erythema: sensitivity correlates with the concentrations of psoralen in suction blister fluid
Authors: U-C. Yeo, J-H. Shin, J-M. Yang, K-B. Park, M-M. Kim, H-S. Bok, E-S. Lee
Journal: British Journal of Dermatology (2000)

Since the advent of psoralen‐ultraviolet A (PUVA) therapy, the value of plasma 8‐methoxypsoralen (8‐MOP) concentrations to predict PUVA‐induced erythema has been widely investigated. Plasma 8‐MOP concentrations have not been proportional to, and cannot alone predict, the degree of PUVA‐induced erythema. We assumed that PUVA‐induced erythema was related more closely to psoralen concentrations in the skin tissue rather than those within blood vessels. This study was designed to investigate the correlations between the 8‐MOP concentrations in suction blister fluid (SBF) and in plasma, with the degree of PUVA‐induced erythema. 8‐MOP concentrations in plasma and SBF were measured in 15 vitiligo patients and 11 volunteers. Blood and SBF samples were collected 2 h after taking 8‐MOP, and 8‐MOP concentrations in plasma and SBF were quantified using reverse‐phase high‐performance liquid chromatography. Eleven volunteers were phototested using a series of doses of ultraviolet A at the time of sampling. The erythema responses were estimated visually to determine the minimal phototoxic dose (MPD). SBF 8‐MOP concentrations showed a weak positive correlation with plasma 8‐MOP concentrations, which means that we could not predict the exact SBF 8‐MOP concentrations using the plasma 8‐MOP concentrations. The MPD showed a better correlation with the log of the SBF 8‐MOP concentration than with that of the plasma 8‐MOP concentration. These results show that plasma 8‐MOP concentration cannot represent the exact SBF 8‐MOP concentration, and that SBF 8‐MOP concentrations, which are representative of the skin tissue 8‐MOP level, are more closely related to the erythemal sensitivity during PUVA therapy.
CHRONIC HYPOCHROMIC ANEMIA IN WOMEN ITS GASTROINTESTINAL, GYNECOLOGIC, ENDOCRINE AND PSYCHIATRIC FEATURES
Authors: Solomon G. Meyers, A. Hazen Price, H. C. Mack, Linus J. Foster, E. A. Sharp
Journal: Annals of Internal Medicine (1938)

Article1 March 1938CHRONIC HYPOCHROMIC ANEMIA IN WOMEN ITS GASTROINTESTINAL, GYNECOLOGIC, ENDOCRINE AND PSYCHIATRIC FEATURESSOLOMON G. MEYERS, M.D., A. HAZEN PRICE, M.D., F.A.C.P., H. C. MACK, M.D., LINUS J. FOSTER, M.D., E. A. SHARP, M.D., F.A.C.P.SOLOMON G. MEYERS, M.D.Search for more papers by this author, A. HAZEN PRICE, M.D., F.A.C.P.Search for more papers by this author, H. C. MACK, M.D.Search for more papers by this author, LINUS J. FOSTER, M.D.Search for more papers by this author, E. A. SHARP, M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-11-9-1590 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptSo-called idiopathic hypochromic anemia has been frequently discussed in the literature. Most authors emphasize the hematological aspects, neglecting other important clinical features presented by patients with hypochromic anemia which seem to us to have an important etiologic bearing. Moreover, failure to take proper cognizance of these conditions in our opinion precludes the possibility of intelligent management. These conclusions are the result of studies which will be reported below. In our opinion, the term idiopathic as applied to hypochromic anemia is seldom justified.The present report is based on an intensive study of 26 women with chronic hypochromic anemia, special emphasis...Bibliography1. METTIERKELLOGGRHINEHART SRFJF: Chronic idiopathic hypochromic anemia, Am. Jr. Med. Sci., 1933, clxxxvi, 694-704. CrossrefGoogle Scholar2. KANTOR JL: The unstable colon, South. Med. Jr., 1932, xxv, 29-37. CrossrefGoogle Scholar3. JORDANKIEFER SMED: The irritable colon, Jr. Am. Med. Assoc., 1929, xciii, 592-595. CrossrefGoogle Scholar4. GRAYWINTROBE LAMM: Chronic hypochromic anemia in women, Am. Jr. Obst. and Gynec., 1936, xxxi, 3-13. CrossrefGoogle Scholar5. HADEN RL: Multiple specific nutritional deficiency disease in the adult, Jr. Am. Med. Assoc., 1936, cvi, 261-265. CrossrefGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Detroit, Michigan*Received for publication May 17, 1937.From Harper Hospital and Wayne University College of Medicine, Detroit. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byIron Deficiency 1 March 1938Volume 11, Issue 9Page: 1590-1599KeywordsAnemiaHematology and oncologyHospital medicineResearch laboratories ePublished: 1 December 2008 Issue Published: 1 March 1938 PDF downloadLoading ...
Psychotherapy of the narcissistic personality disorder patient: two contrasting approaches
Authors: Gerald Adler
Journal: American Journal of Psychiatry (1986)

The differences in the theoretical and clinical approaches that Kernberg and Kohut have defined are used to discuss the psychodynamics and psychotherapy of the narcissistic personality disorder patient. Their contrasting contributions help clarify the nature of these patients' difficulties, the possibility that there is a spectrum of narcissistic disorders, the effect of existing theory and the personalities of clinicians-theoreticians on the collection of clinical data, and the effects of theoretical formulations on the psychotherapeutic process.
Abstract P049: Principal Component Analysis of Dietary Patterns and the Risk of Cardiovascular Disease and Mortality in Older British Men
Authors: Janice Atkins, Peter Whincup, Richard Morris, Lucy Lennon, Olia Papacosta, Goya Wannamethee
Journal: Circulation (2015)

Background: Diet quality is a major risk factor for morbidity and mortality, but few studies have examined the relationship between dietary patterns and the risk of cardiovascular disease (CVD) and mortality in older adults. We examined prospective associations between dietary patterns defined using principal component analysis and the risk of CVD and all-cause mortality in older British men. Methods: 3226 men aged 60-79 years from the British Regional Heart Study, free from CVD at baseline, were followed-up for 11 years. Baseline food frequency questionnaire data were used to generate dietary intake data on 34 food groups. Principal component analysis identified dietary patterns which were then categorised according to quartiles of adherence. Cox proportional hazards regression examined associations between dietary patterns and risk of all-cause mortality, CVD mortality, CVD events and coronary heart disease (CHD) events, adjusting for confounders. Results: Principal component analysis identified three interpretable dietary patterns, which explained 20.8% of the total variance. An ‘unhealthy’ dietary pattern explained the greatest single proportion of the variance (7.9%) and was characterised by consumption of red meat, meat products, white bread, fried potato and eggs. A ‘healthy’ dietary pattern was characterised by consumption of poultry, fish, fruit, vegetables, legumes, pasta, rice, wholemeal bread, eggs and olive oil and explained 7.1% of the variance. Finally, a ‘sweet’ dietary pattern was characterised by consumption of biscuits, puddings, chocolate, sweets, sweet spreads and breakfast cereal and explained 5.8% of the variance. There were 899 deaths, 316 CVD deaths, 569 CVD events and 301 CHD events during follow-up. An ‘unhealthy’ dietary pattern was associated with a graded increase in risk of all-cause mortality, after adjustment for sociodemographic, behavioural and cardiovascular risk factors (highest vs. lowest quartile; HR: 1.44, 95% CI: 1.13-1.84, p-trend = 0.007). No significant associations were seen between the risk of all-cause mortality and the ‘healthy’ diet (highest vs. lowest quartile; HR: 0.83, 95% CI: 0.66-1.04, p-trend = 0.28) or the ‘sweet’ diet (highest vs. lowest quartile; HR: 1.00, 95% CI: 0.77-1.29, p-trend = 0.71). None of the dietary patterns were significantly associated with cardiovascular outcomes (CVD mortality, CVD events or CHD events). Conclusions: Dietary patterns are an important risk factor for all-cause mortality in the elderly. Older adults should avoid a high consumption of components of an ‘unhealthy’ dietary pattern to reduce the risk of all-cause mortality.
Abstract 5340: Cardiac Resynchronization Therapy Corrects Dyssynchrony-induced Regional Gene Expression Changes on a Genomic Level
Authors: Andreas S Barth, Takeshi Aiba, Victoria Halperin, Deborah DiSilvestre, Chakir Khalid, Veronica L Dimaano, Wayne Yu, Theodore Abraham, David Kass, Gordon F Tomaselli
Journal: Circulation (2008)

Purpose: Cardiac Resynchronization Therapy (CRT) improves symptoms and reduces mortality in patients with heart failure (HF). To characterize the molecular processes associated with functional improvement in CRT, we used a genomic approach in a large animal HF model. Methods: After creation of a left bundle branch block (LBBB), dogs in the HF group were subjected to either rapid atrial pacing with 200 bpm for 6 weeks (dyssynchronous HF, DHF, n=10), or 3 weeks of atrial pacing followed by 3 weeks of biventricular stimulation at 200bpm (CRT, n=9). Control animals without LBBB were not paced (NF, n=11). After 6 weeks, RNA from anterior and lateral regions of the LV was hybridized onto canine 44K arrays. Statistical Analysis of Microarrays (SAM) was used for data analysis. Results: Echocardiographically, CRT led to a significant increase in stroke volume (+27%, p=0.03) which translated into a non-significant increase in EF (DHF 25±4%; CRT 31±3% (p=0.15); NF 67±3%). A multiclass analysis of NF, DHF and CRT animals identified 1050 differentially expressed transcripts between anterior and lateral walls with a false discovery rate of 5%. For all these transcripts, dyssynchrony-induced expression changes were reversed by CRT to levels of NF hearts. As a result, CRT samples clustered with NF rather than DHF samples. Of particular interest were genes encoding for signal transduction pathways and contractile processes. Conclusions: By using a whole genome approach, we demonstrate a profound effect of electrical activation on the regional cardiac transcriptome. This is the first study showing that dyssynchrony-induced gene expression changes can be corrected by CRT on a genome-wide level.
Alpha-2 macroglobulin is genetically associated with Alzheimer disease
Authors: Deborah Blacker, Marsha A. Wilcox, Nan M. Laird, Linda Rodes, Steven M. Horvath, Rodney C.P. Go, Rodney Perry, Bracie Watson, Susan S. Bassett, Melvin G. McInnis, Marilyn S. Albert, Bradley T. Hyman, Rudolph E. Tanzi
Journal: Nature Genetics (1998)
Homozygous mutations in ARIX(PHOX2A) result in congenital fibrosis of the extraocular muscles type 2
Authors: Motoi Nakano, Koki Yamada, Jennifer Fain, Emin C. Sener, Carol J. Selleck, Abdulaziz H. Awad, Johan Zwaan, Paul B. Mullaney, Thomas M. Bosley, Elizabeth C. Engle
Journal: Nature Genetics (2001)