tbuckley/cabot-search huggingface dataset:
Psychosomatic Medicine
Authors: W. Schüffel
Journal: Psychotherapy and Psychosomatics (1973)

202 patients from 4 medical wards of a teaching hospital were seen by two psychosomatic consultants over a period of 12 months. The 3 main activities performed by the consultants were: (1) giving advice in diagnosis and therapy as far as psychological factors were concerned; (2) interaction-centred interventions in cases of patients with affective disturbances; (3) holding therapy sessions either by the consultant himself or supervision of other members of the operational group. The diagnoses of the patients can be subdivided into 3 main groups: (1) patients with functional disorders (42); (2) patients with malignoma (41); (3) patients with various diseases covering the whole range of internal medicine (119). It is concluded that both patient- and group-centred approaches are required. The psychosomatic consultant will also be confronted with patients representing the whole range of the subject he is attached to (not only the so-called 'psychosomatic patients')
Abstract 17399: Glutathione-S-Transferase P Regulates Neovascularization in the Remodeling Heart via Effects on Endothelial Progenitor Cells and Reparative Monocytes
Authors: Guihua Zhou, Hai Zhong, Yixin Wu, Chiao-Wang Sun, Timothy M Townes, Sumanth D Prabhu
Journal: Circulation (2014)

Glutathione- S -transferase P (GSTP) modulates c-Jun N-terminal kinase (JNK) activation and the proliferation of bone marrow (BM) myeloid progenitors; however, its effects on endothelial progenitor cells (EPCs) and neovascularization are unknown. Hypothesis: GSTP promotes EPC function in a JNK-dependent manner, thereby supporting neovascularization in heart failure (HF). GSTP-/- mice exhibited significantly (p&lt;0.01 vs. wild type [WT]) reduced circulating and BM EPCs, increased pro-inflammatory F4/80 + CD11b + Gr-1 hi monocytes, diminished BM EPC function (proliferation, migration, and vascular tube formation), and increased BM JNK phosphorylation. These effects were reversed upon treatment with the JNK inhibitor SP600125. HF was induced by left coronary ligation in WT and GSTP-/- mice (sham control). GSTP-/- HF mice exhibited (p&lt;0.05 vs. WT HF): 1) fewer circulating and BM EPCs and increased pro-inflammatory monocytes; 2) exaggerated left ventricular (LV) remodeling and inflammation; and 3) reduced myocardial capillary density. Next, chimeric mice were generated via BM ablation in WT mice and reconstitution with either GSTP-/- (GSTP-/-c) or WT (WTc) BM. GSTP-/-c and WTc mice underwent coronary ligation or sham operation (n = 8-15/group). As compared with WTc HF, GSTP-/-c HF hearts had significant (p &lt; 0.01): 1) exaggeration of LV remodeling and dysfunction; 2) increases in remote zone fibrosis; 3) reductions in capillary density and VEGF-A, -B, and -C gene expression; and 4) augmentation of interleukin (IL)-1β and IL-6 expression. GSTP-/-c mice also exhibited (p &lt; 0.01 vs. WTc mice) increased BM JNK activation, reduced circulating EPCs, increased pro-inflammatory CD11b + Ly6C hi monocytes, but comparable Ly6C low monocytes at baseline. Moreover, at 3 and 7 d post-ligation, GSTP-/-c HF mice had fewer circulating EPCs and reparative Ly6C low monocytes, but significantly higher Ly6C hi monocytes. Conclusion: GSTP promotes EPC function and reparative monocyte mobilization, and suppresses inflammation, thereby improving angiogenic gene expression, neovascularization and LV remodeling after infarction. Hence, human GSTP polymorphisms, which are frequent, may impact cardiac reparative capacity in patients with myocardial infarction.
PoInTree: A Polar and Interactive Phylogenetic Tree
Authors: Carreras Marco, Gianti Eleonora, Sartori Luca, Plyte Simon Edward, Isacchi Antonella, Bosotti Roberta
Journal: Genomics Proteomics & Bioinformatics (2005)

Abstract PoInTree (Polar and Interactive Tree) is an application that allows to build, visualize, and customize phylogenetic trees in a polar, interactive, and highly flexible view. It takes as input a FASTA file or multiple alignment formats. Phylogenetic tree calculation is based on a sequence distance method and utilizes the Neighbor Joining (NJ) algorithm. It also allows displaying precalculated trees of the major protein families based on Pfam classification. In PoInTree, nodes can be dynamically opened and closed and distances between genes are graphically represented. Tree root can be centered on a selected leaf. Text search mechanism, color-coding and labeling display are integrated. The visualizer can be connected to an Oracle database containing information on sequences and other biological data, helping to guide their interpretation within a given protein family across multiple species. The application is written in Borland Delphi and based on VCL Teechart Pro 6 graphical component (Steema software).
Book: War and Public Health
Authors: A. Zwi
Journal: BMJ (1999)

Barry S Levy, Victor W Sidel Oxford University Press, £42.50, pp 432 ISBN 0195108140 ——————— Rating: ![Graphic][1]</img>![Graphic][2]</img>![Graphic][3]</img> This book provides an excellent collection of material on the impact of war on public health, and it provides a valuable starting point for much needed debate. War and violent political conflict are detrimental to health and health systems. In some cases, of course, violent political conflict may lead to the longer term establishment of a more equitable health and social system, but even in these situations populations and systems suffer in the short to medium term. War and Public Health highlights the debates that took place in the middle 1980s and early 1990s regarding nuclear and other weapons of mass destruction, the impact of war on public health, and the role of health workers in peace advocacy. In 1998 we witnessed the testing of nuclear devices in India and Pakistan; anxieties about … [1]: /embed/inline-graphic-1.gif [2]: /embed/inline-graphic-2.gif [3]: /embed/inline-graphic-3.gif
Bone Morphogenetic Protein 2 (BMP-2) promotes foci formation through the activation of mammalian target of rapamycin
Authors: John E. Langenfeld, Elaine Langenfeld, Yingxin Kong
Journal: Cancer Research (2005)

Proc Amer Assoc Cancer Res, Volume 46, 2005

5478 

BMP-2 is essential for normal embryonic development. The mature BMP-2 protein is highly over-expressed in nearly all human lung carcinomas. We have shown that BMP-2 stimulates the proliferation of the A549 lung cancer cell line when cultured in media containing serum, but not in serum free medium. The purpose of this study was to examine the mechanisms BMP-2 regulates cell survival and proliferation. This study reveals that BMP-2 (10 ng/ml) induces the phosphorylation of mammalian target of rapamycin (mTOR) in A549 and H1299 cells, which is inhibited by phosphoinositide 3-kinase (PI-3K) antagonist Ly 294002. mTOR promotes transformation through the regulation of translation, which is mediated in part by the activation of p70 S6 kinase. We find that BMP-2 induces the phosphorylation of p70 S6 kinase, which is blocked by the mTOR antagonist rapamycin and LY 294002. In addtion, we show that BMP-2 stimulates the expression of cyclin E that is mediated through the activation of p70 S6 kinase. Furthermore, forced expression of BMP-2 significantly increases foci formation of A549 cells that is abrogated by rapamycin. This study shows that BMP-2 promotes foci formation that involves the activation of the mTOR/p70 S6 kinase pathway. Furthermore, BMP-2 induced transformation also involves the induction of cyclin E that occurs through activation p70 S6 kinase
A neuropsychological hypothesis explaining posttraumatic stress disorders
Authors: Lawrence C. Kolb
Journal: American Journal of Psychiatry (1987)

The author reports findings from recent psychophysiological and biochemical research on Vietnam combat veterans with chronic posttraumatic stress disorder. Applying these data and the analogy of the known functional and structural defects in the peripheral (cranial) sensory system consequent to high-intensity stimulation, he hypothesizes that cortical neuronal and synaptic changes occur in posttraumatic stress disorder as the consequence of excessive and prolonged sensitizing stimulation leading to depression of habituating learning. He postulates that the "constant" symptoms of the disorder are due to the changes in the agonistic neuronal system which impair cortical control of hindbrain structures concerned with aggressive expression and the sleep-dream cycle.
Use and Effectiveness of Intravenous Heparin Therapy for Treatment of Acute Myocardial Infarction in the Elderly
Authors: Harlan M Krumholz, John Hennen, Paul M Ridker, Jaime E Murillo, Yun Wang, Viola Vaccarino, Edward F Ellerbeck, Martha J Radford
Journal: Journal of the American College of Cardiology (1998)

We sought to determine the use and association with 30-day mortality of intravenous heparin for the treatment of acute myocardial infarction in elderly patients not treated with a reperfusion strategy and without contraindications to anticoagulation.The benefit of using full-dose intravenous heparin for the treatment of acute myocardial infarction in the elderly is not known.We conducted a retrospective cohort study using hospital medical records of all Medicare beneficiaries admitted to the hospital with an acute myocardial infarction in Alabama, Connecticut, Iowa and Wisconsin from June 1992 through February 1993.Among the 6,935 patients > or = 65 years old who had no absolute chart-documented contraindications to heparin, 3,227 (47%) received early full-dose intravenous heparin therapy. After adjustment for baseline differences in demographic, clinical and treatment factors between patients with and without heparin, the use of heparin (odds ratio 1.02, 95% confidence interval 0.87 to 1.18) was not associated with a significantly better 30-day mortality rate.Although intravenous heparin was commonly used for treatment of acute myocardial infarction in the elderly, it was not associated with an improved 30-day mortality rate. Although the findings of this observational study must be interpreted with care, they lead us to question whether the prevalent use of intravenous heparin has therapeutic effectiveness in this population.
95. Retargeting AAV-2 to Angiogenic Endothelial Cells with Tumor Vasculature Specific Capsid Variants
Authors: Andreas Riederer, Bernard Kaess, Luca Perabo, Hildegard Buening, Michael Hallek
Journal: Molecular Therapy (2004)

A promising target for cancer gene therapy is the tumor endothelium, which forms the inner wall of tumor vessels and is therefore essential for the oxygen and nutrient supply of the tumor. On these tumor vessels specific surface molecules are upregulated or specific isoforms are expressed. The development of targeting technologies allows the generation of viral vectors specifically tailored to bind to such molecules. Genetic incorporation of receptor specific ligands into the capsid position I-587 (Girod et al., 1999) seems to be the most promising approach for the generation of retargeting vectors based on the adeno-associated virus (AAV2). Therefore, we used this position to insert previously described tumor vasculature specific peptides into the capsid of AAV2 vectors. These targeting vectors could be generated with titers comparable to wild type AAV2. We could demonstrate that infections of these new retargeting vectors were mediated by the inserted peptides and that the same insertions interfered with the usage of AAV2s primary receptor heparan sulfate proteoglycan. Furthermore, two of the four peptides successfully shifted the viral tropism towards angiogenic HUVEC, an in vitro model for tumor vasculature.
Abstract P2-08-02: Autoimmunity to centrosomal and proteasome proteins in breast cancer. A link to chromosome instability?
Authors: Marie-Claire Maroun, Ofelia Olivero, Judith Abrams, Wei Chen, Azadeh Stark, Carol Peebles, Larry Tait, Dhanajay Chitale, Félix Fernández Madrid
Journal: Cancer Research (2015)

Abstract BACKGROUND. Perturbation of centrosomal or centrosome-associated proteins has been observed in nearly all human solid tumors and has been implicated in the origin of chromosomal instability. Ubiquitin-proteasome degradation is highly dependent on the organizing capabilities of the centrosomes. Here we report that autoantibodies in breast cancer [BC] sera target centrosomal proteins as well as important proteins involved in proteasome protein degradation. METHODS. We immunoscreened a T7 cDNA library of BC proteins and the association of the cloned autoantigens with BC was studied by autoantigen microarray analysis. We used immunohistochemistry [IHC] to investigate the expression of the centrosome and centrosome-associated autoantigens identified. RESULTS. Immunoscreening with BC sera led to the identification of autoantibodies recognizing epitopes developing in a family of proteins located on the centrosomes such as NIMA-related kinase 7, dynein heavy chain domain 3, peri-centriolar material-1, isomorph CRA, and stathmin-1, the ubiquitin-conjugating enzyme E2, the proteasome 26S subunit and the SUMO/sentrin peptidase. Antibody reactivity to these proteins which are associated with centrosome assembly, microtubule function and protein degradation were highly associated with the diagnosis of BC. IHC staining of paraffin-embedded BC sections with specific antibodies showed that aurora and stathmin-1 and other centrosome antigens are expressed in BC. CONCLUSIONS. The discovery of autoantibodies targeting important centrosome and proteasome proteins associated with BC suggests that this immune reactivity could be related to autoimmunity developing in BC. Our findings indicate that these autoantibodies might be biomarkers of early BC and suggest the possibility of a link with chromosomal instability in BC. Citation Format: Marie-Claire Maroun, Ofelia Olivero, Judith Abrams, Wei Chen, Azadeh Stark, Carol Peebles, Larry Tait, Dhanajay Chitale, Félix Fernández Madrid. Autoimmunity to centrosomal and proteasome proteins in breast cancer. A link to chromosome instability? [abstract]. In: Proceedings of the Thirty-Seventh Annual CTRC-AACR San Antonio Breast Cancer Symposium: 2014 Dec 9-13; San Antonio, TX. Philadelphia (PA): AACR; Cancer Res 2015;75(9 Suppl):Abstract nr P2-08-02.
Tungiasis
Authors: Vaira Fabrizio, Nazzaro Gianluca, Veraldi Stefano
Journal: JAMA Dermatology (2014)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Dermatology HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Dermatology journal
Study's conclusions are implausible
Authors: A Houghton
Journal: BMJ (1995)

tional leaflet published by the National Society for the Prevention of Cruelty to Children and the Department of Health, Handle with Care, is a starting point for educating parents and other carers.This leaflet can be used by midwives and health visitors as a basis for individual work with parents, particularly targeting those considered to be most at risk.We stated that shaking a baby is dangerous, and this is recognised by paediatricians.The purpose of the editorial and the campaign by the National Society for the Prevention of Cruelty to Children was to alert carers to the dangers of shaking infants
Impaired Physicians and the ADA
Authors: Laura Rothstein
Journal: JAMA (2015)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Anomalous Origin With Myocardial Bridging in Coronary Artery
Authors: Ryusuke Yamamoto, Masa-aki Kawashiri, Hayato Tada, Toshinari Tsubokawa, Katsuharu Uchiyama, Tetsuo Konno, Kenshi Hayashi, Takekatsu Saito, Kunio Ohta, Akihiro Yachie, Masakazu Yamagishi
Journal: Journal of the American College of Cardiology (2012)
Abstract 1593: Aging Affects Matrix Metalloproteinase Promoter Activity in Myocardial Fibroblasts
Authors: Robert E Stroud, Shenikqua Bouges, Eileen I Chang, I. M Mains, Nina J Sheats, Juozas A Zavadzkas, Rupak Mukherjee, Francis G Spinale
Journal: Circulation (2008)

A structural milestone of the aging myocardium is abnormal extracellular matrix (ECM) accumulation, accompanied by abnormal (matrix metalloproteinase (MMP) expression, such as MMP-2 and MMP-9. Sinc...
Membrane-bound interleukin 12 induced stronger antitumor immunity than soluble interleukin 12 without inducing circulating interferon γ
Authors: Mi-Hua Tao, Wen-Yu Pan, Pin-Yi Wu, Chia-Hui Lo, Chun-Chi Chen
Journal: Cancer Research (2005)

5995   Interleukin 12 (IL-12) has been shown to successfully treat tumors  in vivo  in a variety of murine model systems. However, the therapeutic application of IL-12 is limited by its severe toxicity. One way to avoid IL-12-induced toxicity is by local delivery of IL-12 using gene therapy vectors, which has been shown in many studies to induce local high concentrations of IL-12 with significant therapeutic effect. However, an elevated serum IL-12 was still observed in the circulation, which might cause some unwanted side effects. To overcome this problem, we propose to apply a membrane-bound IL-12 in cancer gene therapy. The membrane-bound IL-12 was generated by fusing murine single-chain IL-12 with murine B7-1 transmebrane domain and was retrovirally transduced into murine CT26 colon adenocarcinoma. The cell surface IL-12 maintained its biological activity as demonstrated by the ability of stimulating proliferation and IFN-γ secretion of mouse splenocytes. In syngeneic animals, expression of membrane IL-12 in CT26 cells inhibited the growth of subcutaneous tumors and significantly suppressed lung metastasis. Studies in immunocompromised hosts and animals that were selectively depleted of various lymphocyte populations showed that CD8 +  T cells and, to a lesser extent, CD4 +  T cells are crucial for the antitumor activity of membrane-bound IL-12. Compared with CT26 cells producing soluble form IL-12, tumor cells with membrane-bound IL-12 elicited stronger cytotoxic T lymphocyte responses and a better protection against subsequent challenge of wild-type tumor cells. Most importantly, both serum IL-12 and IFN-γ, which is responsible for most of the toxicities associated with IL-12 treatment, were not detectable in mice receiving CT26 cells expressing membrane-bound IL-12, whereas serum IFN-γ was increased significantly in mice receiving tumors that produced secreted form IL-12. Altogether, these results suggest that expression of IL-12 on tumor cell surface not only may prevent the severe toxicity associated with IL-12 therapy, but it also promotes a superior antitumor immunity than soluble IL-12.
Abstract 2857: S100A14 plays an important role in cell growth and metastasis of epithelial ovarian cancer through PI3K-AKT pathway
Authors: Hanbyoul Cho, Maria Lee, Ha-Yeon Shin, Wookyeom Yang, Eun-ju Lee, Hyunja Kwon, Sol Kim, Jae-Hoon Kim
Journal: Cancer Research (2014)

Abstract Background: S100A14 is an EF-hand containing calcium protein of the S100 protein family that exerts its biological effects on different types of cancers. The roles of S100A14 in tumorigenesis and its underlying mechanism have not been fully understood. This study aims to investigate the clinical significance and possible mechanisms of action of S100A14 in the growth and metastasis of epithelial ovarian cancer (EOC). Method: S100A14 expression in ovarian cancer was studied using a total of 104 ovarian tissue specimens (13 normal ovarian tissues, 10 benign ovarian tumors, 10 borderline ovarian tumors, and 71 EOC tissues) via immunohistochemistry. We investigated the possible functions of S100A14 in EOC stable cell by lentivirus-mediated overexpression and short hairpin RNA (shRNA). Results: S100A14 protein was significantly over-expressed in EOC cells and tissues. S100A14 expression was significantly associated with advanced stage (P&amp;lt;0.001), serous type (P=0.004), and poor tumor grade (P&amp;lt;0.001). Patients with S100A14 overexpression had shorter overall (Hazard Ratio = 4.53 [1.16-17.69], P=0.029) and disease-free survival (Hazard Ratio = 3.10 [1.22-7.89], P=0.017) in multivariate analysis. In vitro analysis of cell function revealed that cell proliferation, migration and invasion were regulated by S100A14. We investigated the underlying mechanism and found that the phosphorylation levels of AKT have increased after S100A14 overexpression. Inhibition of AKT by a specific AKT inhibitor (MK-2206) and PI3K inhibitor (wortmannin) at least partly reversed the AKT-phosphorylation events in S100A14-overexpressed cells. Conclusions: The data revealed the aberrant expression of S100A14 in ovarian cancer, suggesting a potentially important role of S100A14 in ovarian carcinogenesis; S100A14 regulated AKT via phosphorylation of its ser473 site also implies that S100A14 could be used as a novel therapeutic target for ovarian cancer treatment. Citation Format: Hanbyoul Cho, Maria Lee, Ha-Yeon Shin, Wookyeom Yang, Eun-ju Lee, Hyunja Kwon, Sol Kim, Jae-Hoon Kim. S100A14 plays an important role in cell growth and metastasis of epithelial ovarian cancer through PI3K-AKT pathway. [abstract]. In: Proceedings of the 105th Annual Meeting of the American Association for Cancer Research; 2014 Apr 5-9; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2014;74(19 Suppl):Abstract nr 2857. doi:10.1158/1538-7445.AM2014-2857