tbuckley/cabot-search huggingface dataset:
Perforation of the Tricuspid Valve by a Transvenous Pacemaker
Authors: Lawrence Gould
Journal: JAMA (1974)

FOR the past 12 years, permanent and temporary transvenous cardiac pacing has become not only an accepted, but an indispensable and many-pronged tool. It has been used extensively in the treatment of the Adams-Stokes syndrome, and in patients with symptomatic bradyarrhythmia with or without a myocardial infarction. Recently, electrical pacemakers have been employed to override life-threatening arrhythmia refractory to pharmacologic approaches. 1   Currently, permanent cardiac pacing is usually accomplished with the insertion of an endocardial electrode through a peripheral vein. Although this approach has simplified pacemaker insertion, various complications can develop. Displacement of the catheter electrode has been reported in all large series and has had an incidence of displacement of 10% to 15%. 2,3 Other complications include disruption of the electrode, 4 atrial thrombi, 5 air embolism, 3 endothelization of the catheter, 6 phrenic nerve stimulation, and myocardial perforation. This report describes the perforation of a tricuspid value.  Report
Functional assessment of proliferating hepatocytes stimulated by hepatic stimulatory substance in ascorbic acid biosynthetic enzyme-deficient rats
Authors: F Nakazawa, M Sawa, B Jiang, K Onodera, S Kasai, M Mito
Journal: Hepatology (1997)

The functional ability of hepatic stimulatory substance (HSS)-stimulated proliferating hepatocytes was investigated by intrasplenic and/or intraportal transplantation in ascorbic acid (AsA) biosynthetic enzyme-deficient (ODS-od/od) rats that die of osteogenic disorders unless there is AsA supplementation. HSS was extracted from regenerating porcine livers. Hepatocytes isolated from the livers of congeneic ODS-+/+ rats that are capable of synthesizing AsA were transplanted into the spleen (Sp-HTx) and/or the portal vein (Pv-HTx) of ODS-od/od rats. The recipients were divided into eight groups as follows: HSS-untreated groups [group Ia, sham-operated, HTx(-); group IIa, Sp-HTx; group IIIa, Pv-HTx; and group IVa, Sp- and Pv-HTx], HSS-treated groups [group Ib, HSS only; group IIb, Sp-HTx + HSS; group IIIb, Pv-HTx + HSS; and group IVb, Sp- and Pv-HTx + HSS]. The recipients were given a diet and water containing AsA for 6 weeks after HTx, and AsA supplementation was then halted. The average bromodeoxyuridine (BrdU) labeling index (LI) and hepatocyte-occupied ratio in the spleen (H/S ratio) of HSS-treated rats were significantly higher than those of HSS-untreated rats. All the rats in HSS-untreated groups and group Ib died by 8 weeks after the cessation of AsA. In HSS-treated groups IIb, IIIb, and IVb, the survival rates were 60%, 50%, and 80%, respectively, at 16 weeks after HTx. The average serum AsA level of the surviving rats in groups IIb, IIIb, and IVb was significantly higher than that in HSS-untreated groups. These results indicate that HSS treatment induced rapid proliferation of transplanted hepatocytes in the spleen and the portal vein, and that these proliferating hepatocytes synthesized AsA and improved the survival rate of ODS-od/ od rats.
756 RESULTS OF THE PEG-IFN TREATMENT IN THE HBEAG POSITIVE AND NEGATIVE CHRONIC HEPATITIS B PATIENTS: POST-TREATMENT ONE YEAR RESULTS OF THREE TURKISH CENTERS
Authors: T. Yamazhan, B. Kurtaran, H. Pullukcu, E. Yuksel, D. Ozkaya, M.I. Tasbakan, O.R. Sipahi, R. Durusoy, H.S. Aksu
Journal: Journal of Hepatology (2011)
Tumor-specific donor lymphocyte infusion therapy with allogeneic T cells utilizing novel retrovirus vector silencing endogenous TCR expression
Authors: Hiroaki Ikeda, Hiroaki Ueno, Ayumi Kawamura, Naoko Imai, Sachiko Okamoto, Junichi Mineno, Kazutoh Takesako, Hiroshi Shiku
Journal: Journal for ImmunoTherapy of Cancer (2014)

Meeting abstracts Donor Lymphocyte infusion (DLI) is a therapy for the patients with relapsed hematological malignancy after allogeneic hematopoetic stem cell transplantation. However, the development of Graft-Versus-Host Disease (GVHD) is a serious adverse event and the efficacy is limited when
Antibiotics for Otitis Media: A Clarification
Authors: Richard M. Rosenfeld
Journal: JAMA (1994)

<h3>To the Editor.</h3> —Although the review by Williams et al<sup>1</sup>provides additional evidence for a significant short-term impact of antibiotics on otitis media with effusion (OME), caution is necessary when generalizing their results. The "brouhaha" alluded to in the article's subtitle refers to the value of a therapeutic course of antimicrobials for OME; however, the authors included four trials of prophylactic antimicrobials<sup>2-5</sup>—once-daily administration of a subtherapeutic dose of medication—in their meta-analyses of short-term and long-term OME outcomes. This confounds meaningful interpretation of the results by underestimating the impact of therapeutic antibiotics on OME control. Another caution in generalizing the results concerns the OME meta-analysis of intermediate- to long-term outcomes. The hypothesis tested was whether a single course of therapeutic or prophylactic antibiotic conferred benefits lasting up to 11 months; OME relapse was untreated when it occurred in each of the individual studies. Of interest to clinicians, however,
Not every child with diabetes needs insulin
Authors: D. Iafusco, A. E. Scaramuzza, A. Galderisi, A. Cocca, R. Giugliano, G. V. Zuccotti, F. Prisco
Journal: BMJ (2010)

Insulin is miraculous,1 and, as happens with most good and effective drugs, it has tended to be used whenever doctors meet a child with high blood sugar values. This presupposes that hyperglycaemia in children always means type 1 diabetes, overlooking the existence of many …
The Progression of Fenfluramine-Associated Valvular Heart Disease Assessed by Echocardiography
Authors: Steven T. Mast, James G. Jollis, Thomas Ryan, Kevin J. Anstrom, Jack L. Crary
Journal: Annals of Internal Medicine (2001)

Background: An association between the dietary suppressants fenfluramine and dexfenfluramine and valvular heart disease was first described in patients from North Dakota and Minnesota in 1997. Limited data are available on the natural history of this valvulopathy after discontinuation of drug therapy. Objective: To follow the progression of fenfluramine-associated valvular heart disease after discontinuation of therapy by using serial echocardiography. Design: Retrospective cohort study. Setting: Regional medical center in Fargo, North Dakota. Patients: 50 patients with previous exposure to fenfluramines who had at least mild mitral regurgitation or aortic regurgitation after exposure to fenfluramines on serial echocardiography between December 1994 and February 1999 (96% were female, mean body mass index was 36.6 kg/m2, and mean duration of drug exposure was 447 days). Measurements: Serial echocardiograms were reviewed by two echocardiographers who were blinded to the order of image acquisition. The severity of valvular regurgitation and presence or absence of valve leaflet restriction were assessed. Results: As described in the initial report, significant valvular disease on initial postexposure echocardiography was common in this cohort; 38 patients (76%) had at least mild mitral regurgitation and 43 patients (86%) had at least mild aortic regurgitation. On serial echocardiograms obtained an average of 356 days apart, mitral regurgitation improved by at least one grade in 17 patients (P = 0.001) and aortic regurgitation improved by at least one grade in 19 patients (P = 0.004). Nineteen and 22 patients, respectively, experienced no change in severity of mitral and aortic regurgitation. Two patients in each group experienced worsening of regurgitation by at least one grade. Results were similar for tricuspid (P = 0.002) and pulmonic (P = 0.012) regurgitation. Conclusion: On serial echocardiography, fenfluramine-associated valvular regurgitation improved or remained stable in most patients after therapy ended. Worsening of valvular regurgitation was uncommon. The potential for stabilization or regression of valvular regurgitation should be taken into account when counseling patients and considering the need for and timing of valve surgery.
Toxicity of PBBs with special reference to porphyrinogenic action and spectral interaction with hepatic cytochrome P-450.
Authors: J J Strik
Journal: Environmental Health Perspectives (1978)

Some of the polyhalogenated aromatic compounds (PHAs) which are able to produce porphyria are presently known as environmental contaminants. Chronic exposure to PHAs causes hepatic porphyria in different species. Qualitatively PBBs act comparable to PHAs. An increase in accumulation of porphyrins caused by PHAs is not simply related to an increase of delta-ALAS activity in liver. Heme cannot exert a feedback when porphyria develops. Induction of P-450 mediated drug enzymes is needed. The PHAs interact with P-450 in vitro. The PHAs are converted into a reactive intermediate, not a known metabolite, which depletes liver GSH and then becomes reactive to tissue structures. Mitochondria are damaged; fluorescence of porphyrins is detected in the region of central veins where degenerative change in hepatocytes is most marked. A possible pathological change in the cell membrane permeability is assumed too. In this porphyric stage uropophyrinogen decarboxylase (urogen decarboxylase) is inhibited. The proportion of steroid hormones product by ovaries and testes compared to each other are possibly involved in sensitivity to porphyrinogenic compounds.
Primary lymphoma of the upper small intestine
Authors: K. Nasr, P. Haghighi, K. Bakhshandeh, M. Haghshenas
Journal: Gut (1970)

Seven patients with primary lymphoma involving the upper small intestine and presenting with diarrhoea, non-specific abdominal pain, and clubbing are reported. The disease appears to be more prevalent in young women, and clinical and radiological findings can provide an excellent preliminary diagnosis which is usually confirmed by peroral biopsy of the small intestine. This type of lymphoma is found to be clinically distinguishable both from the primary intestinal lymphomas reported from western countries and also from gastrointestinal involvement as part of a more systemic disease. It appears to be prevalent in the Middle East, and because of clear clinical, radiological, and histological features, it can be singled out from other primary intestinal lymphomas and considered as a distinct clinical entity.
Caught in Colombia's Crossfire
Authors: Brigg Reilley, Silvia Morote
Journal: New England Journal of Medicine (2004)

It is an accepted part of a doctor's job to awaken at night to an emergency call. But in many parts of Colombia, such a visit is often reason for a doctor to shudder with fear. The people knocking on your door may wield guns as they summon you to tend to their ill or wounded compatriots. If you refuse, you might be killed. Yet if you go with them, another armed faction may kill you as a collaborator. If the government discovers you cooperated with any of them, you may be interrogated or detained. This is Colombia's “low-intensity conflict,” . . .
Vascular Ectasia of the Gastric Antrum
Authors: J L Barnett
Journal: New England Journal of Medicine (1998)

Figure 1. A 76-year-old woman presented with a two-month history of intermittent melena, weakness, and anemia that required the transfusion of six units of packed red cells. In the past she had been treated for hypertension and hypothyroidism. Esophagogastroduodenoscopy revealed gastric atrophy and bright red stripes in the antrum of the stomach that radiated spokelike from the pylorus and resembled the stripes of a watermelon — the typical findings of vascular ectasia of the gastric antrum. In Panel A, the view from the distal portion of the gastric body shows a linear pattern of vascular ectasias that begin in the . . .
PEG shielded polymeric double-layered micelles for gene delivery
Authors: Arjen M. Funhoff, Sophie Monge, Rosalie Teeuwen, Gerben A. Koning, Nancy M.E. Schuurmans-Nieuwenbroek, Daan J.A. Crommelin, David M. Haddleton, Wim E. Hennink, Cornelus F. van Nostrum
Journal: Journal of Controlled Release (2004)
Regulating Physician Expert Witness Testimony
Authors: Dan Larriviere
Journal: JAMA (2008)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Sensitive urine tests and human chorionic gonadotrophin secreted during ectopic pregnancy.
Authors: R J Norman, K Reddi, M Kemp, S M Joubert, F Patel
Journal: BMJ (1986)

Glucomannan and risk of oesophageal obstructionGlucomannan (glucose/mannose polymer) is considerably hygroscopic and on contact with water swells and becomes a viscous gel.In this form it is a normal Japanese foodstuff.Like guar (galactose/mannose) it has been used to treat diabetes mellitus.'Recently, dry, non-expanded glucomannan has been marketed in Australia as an aid to dieting, the claim being that it inhibits the appetite by swelling in the stomach, producing what one on 15 August
Differential Diagnosis of Coma
Authors: M. J. Parsonage
Journal: BMJ (1955)

Coma is a state of deep unconsciousness from which the patient cannot be roused by ordinary forms of stimu- lation.There is a total absence of any kind of psychologically understandable response to such stimulation as pinching the skin or vigorous shaking of the patient, but the term " semicoma " is sometimes used to describe those states of less deep unconsciousness in which there may be grimacing or withdrawal movements of a limb on the application of such stimuli.
President's Address to the House of Delegates
Authors: Donovan F. Ward
Journal: JAMA (1964)

Seventy-two days after the American Medical Association inaugurated its 118th President, this beloved physician, Dr. Norman A. Welch, died unexpectedly. The AMA and each of us lost a man of towering strength. But his rich experience, his wide knowledge, and his good humor have not departed from us. Our memories of him are deep, and even death and time shall not take them from us. The sorrow that each of us shares with his bereaved family is profound and lasting. Yet we all can take heart that this man, this physician, this great medical leader, served his fellow man in the true spirit of his Maker. Although I have already been installed as your President, I now pledge to you that I shall continue to carry out the duties of this office to the best of my ability. I dedicate myself and the office to improving the health standards of
Re: Thomas Jefferson
Authors: Harold L. Engel
Journal: JAMA (1977)

<h3>To the Editor.—</h3> Shame on Hilda Slive for her boner in the story about the cover on the July 4 issue (238:6, 1977). Thomas Jefferson was the principal author of the Declaration of Independence and not of the Constitution. He was in France as US minister in 1787 and returned only in 1789 to become President Washington's secretary of state. He had nothing to do with writing the Constitution. But carved inside the dome of the Jefferson Memorial is another of his writings, which should be a source of inspiration for all: "I have sworn upon the altar of God eternal hostility against every form of tyranny over the mind of man."
Strategies for Preventing HIV Transmission
Authors: David R. Holtgrave
Journal: JAMA (2009)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
A study of lymphocytotoxins in families of patients with systemic lupus erythematosus.
Authors: R A Hazelton
Journal: Annals of the Rheumatic Diseases (1984)

Lymphocytotoxic antibodies are a common feature in the sera of patients with systemic lupus erythematosus. This family study, however, has not confirmed the previous findings of an increased incidence in the sera of their relatives. Adsorption studies suggest that when lymphocytotoxins occur in the sera of normal subjects and relatives of patients they have a different specificity and thus significance.
We need a system that accounts for multimorbidity at practice level
Authors: D. J. Shepherd
Journal: BMJ (2012)

As a GP who for 20 years has served a population that is within the 5% most deprived in the country, Mercer and colleagues’ analysis of multimorbidity and the inverse care law matches my experience exactly.1 I systematically ration my time and persistently feel that I am (out of necessity) short changing my patients of professional input.

The current obsession of clinical commissioning groups with …
Evidence that epithelium-derived relaxing factor released by bradykinin in the guinea pig trachea is nitric oxide.
Authors: M Figini, F L Ricciardolo, P Javdan, F P Nijkamp, C Emanueli, P Pradelles, G Folkerts, P Geppetti
Journal: American Journal of Respiratory and Critical Care Medicine (1996)

Bradykinin, applied locally to the airways, is a weak bronchoconstrictor agent in guinea pigs in vivo and it may cause constriction or dilatation of guinea pig airways smooth muscle in vitro. We examined the motor effect of bradykinin perfused through the lumen of isolated guinea pig tracheal tubes with or without nitric oxide (NO) synthase inhibitors. In the presence of NG-nitro-D-arginine methyl ester (D-NAME) or NG-monomethyl-D-arginine (D-NMMA) intraluminal bradykinin caused a moderate concentration-dependent relaxation. In contrast, in the presence of NG-nitro-L-arginine methyl ester (L-NAME) or NG-monomethyl-L-arginine (L-NMMA) tracheas developed a sustained increase in tone, and bradykinin caused a marked, concentration-dependent contraction, both effects being reversible by pretreatment with L-arginine, but not with D-arginine. The ability of bradykinin to relax (in the presence of D-NAME) or contract (in the presence of L-NAME) guinea pig tracheal tubes was not affected by indomethacin. Bradykinin contracted epithelium-denuded tracheas in the presence of either L-NAME or D-NAME. Both contraction and relaxation by bradykinin were blocked by the kinin B2 receptor antagonist, HOE 140. Baseline production of guanosine 3',5'-cyclic monophosphate (cyclic GMP) in strips of guinea pig trachealis in vitro was markedly reduced by L-NAME, but not by D-NAME. Bradykinin increased baseline cyclic GMP concentration. These results indicate that bradykinin releases NO or a NO-related molecule, which, possibly by increasing cyclic GMP concentrations, mediates relaxation and opposes contraction induced by bradykinin itself, and further, that bradykinin releases NO from the tracheal epithelium.
Initial Trends in the Use of the 21-Gene Recurrence Score Assay for Patients With Breast Cancer in the Medicare Population, 2005-2009
Authors: Michaela A. Dinan, Xiaojuan Mi, Shelby D. Reed, Bradford R. Hirsch, Gary H. Lyman, Lesley H. Curtis
Journal: JAMA Oncology (2015)

In 2006, the Centers for Medicare & Medicaid Services approved coverage for the use of the 21-gene recurrence score (RS) assay in women with early-stage, estrogen receptor-positive, node-negative breast cancers to help guide recommendations for adjuvant chemotherapy. Use of the assay in community settings has not been previously examined in a nationally representative sample of patients.To examine trends in the use of the RS assay in routine clinical practice in a nationally representative sample of women with breast cancer.Retrospective observational study of Medicare beneficiaries diagnosed with incident breast cancer between 2005 and 2009, as recorded in a Surveillance, Epidemiology, and End Results data set with linked Medicare claims through 2010.Demographic and clinical variables associated with the use of the assay.A total of 70,802 patients met the study criteria. Use of the RS assay increased from 1.1% in 2005 to 10.1% in 2009 (P < .001). The majority of tests (60.9%) occurred in patients with National Comprehensive Cancer Network-defined intermediate-risk disease (ie, estrogen receptor-positive, node-negative tumors >1 cm). Most patients with other than intermediate-risk disease had borderline indications for testing, including T1b (47.5%) or N1 (26.8%) disease. Testing was associated with younger age, fewer comorbid conditions, higher-grade disease, and being married. Among patients younger than 70 years with intermediate-risk disease, testing rates increased from 7.7% in 2005 to 38.8% in 2009 (P < .001). In multivariable analysis, testing was modestly higher in Northeast than in Western registries (odds ratio, 1.83; 95% CI, 1.49-2.26) but was otherwise not associated with region, local census tract demographic characteristics, black race, location in an urban area, or tumor histologic characteristics.The RS assay was adopted quickly in clinical practice after the Medicare coverage decision in 2006, and use appears to be consistent with guidelines and equitable across geographic and racial groups. Factors influencing adoption of the assay and its impact on adjuvant chemotherapy use in clinical practice remain important areas of study.
Prediction of the severity of aortic stenosis by Doppler aortic valve area determination: Prospective Doppler-catheterization correlation in 100 patients
Authors: Jae K. Oh, Charles P. Taliercio, David R. Holmes, Guy S. Reeder, Kent R. Bailey, James B. Seward, A.Jamil Tajik
Journal: Journal of the American College of Cardiology (1988)
The Science Committee OF THE British Medical Association, THE ANAEMIA OF ANKYLOSTOMIASIS
Authors: W. Nicoll
Journal: BMJ (1912)

WHIIETHER tle reduicinig substance be dextrose, saccliarose, pyrocatechin, or a. mucinoid matters not for the purpose of this slhort paper.There is in nornial cer'cb:o-spinial fluid a clhemical substance wlhich reduces Fellliog's solution, antnd tllis is absent in some cases of meningitis and present in otlhers.There appears in the literatlnre of the subjept considerable confusion as to the cases in which it is present or absent, and considerable uncertainity as, to its value.'