COBALAMIN (VITAMIN B_12) AND THE INTRINSIC FACTOR OF CASTLE
Authors: F H BETHELL, M E SWENDSEID, S MILLER, A A CINTRON-RIVERA
Journal: Annals of Internal Medicine (1951)

Article1 September 1951COBALAMIN (VITAMIN B12) AND THE INTRINSIC FACTOR OF CASTLEFRANK H. BETHELL, M.D., F.A.C.P., MARIAN E. SWENDSEID, Ph.D., STANLEY MILLER, M.D., A. A. CINTRON-RIVERA, M.D.FRANK H. BETHELL, M.D., F.A.C.P.Search for more papers by this author, MARIAN E. SWENDSEID, Ph.D.Search for more papers by this author, STANLEY MILLER, M.D.Search for more papers by this author, A. A. CINTRON-RIVERA, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-35-3-518 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptVitamin B12, originally isolated by Rickes and associates1in the United States and by Lester Smith2in England, is now known to be but one of a group of related compounds for which the generic term "cobalamin" has been proposed by its American discoverers. The several members of this group which have been isolated up to the present time are known as vitamins B12, B12a, B12b,†B12cand B12d.3, 4, 5, 6They have the same basic chemical structure, which is only partially understood but is known to contain one atom of cobalt and the ring structure 5:6, dimethylbenzimidazole in...Bibliography1. RickesBrinkKoniuszyWoodFolkers ELNGFRTRK: Crystalline vitamin B12 , Science 107: 396, 1948. CrossrefMedlineGoogle Scholar2. Smith EL: Purification of anti-pernicious anaemia factors from liver, Nature, London 161: 638, 1948. CrossrefMedlineGoogle Scholar3. KaczkaWolfFolkers EDEK: Vitamin B12. Identification of crystalline vitamin B12a , J. Am. Chem. Soc. 71: 1514, 1949. CrossrefMedlineGoogle Scholar4. PiercePageStokstadJukes JVACELTH: Crystallization of vitamin B12b , J. Am. Chem. Soc. 71: 2952, 1949. CrossrefGoogle Scholar5. BrockmanPierceStokstadBroquistJukes JAJVELHPTH: Some characteristics of a crystalline compound derived from vitamin B12 , J. Am. 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IsaacsBethellRiddleFriedman RFHMCA: Standards for red blood cell increase after liver and stomach therapy in pernicious anemia, J. A. M. A. 111: 2291, 1938. CrossrefGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: *Presented at the Thirty-second Annual Session of the American College of Physicians, St. Louis, Mo., April 11, 1951.From the Thomas Henry Simpson Memorial Institute for Medical Research, University of Michigan, Ann Arbor, Michigan, and the Wayne County General Hospital, Eloise, Michigan.†Vitamin B12b, isolated from liver and other sources, is apparently identical with vitamin B12a, which was obtained by catalytic hydrogenation of crystalline vitamin B12. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byEffects of proteolytic enzymes on vitamin B12 uptake by rat intestinal mucosal homogenates and of proteolytic enzymes and anti-rat intrinsic factor antibodies on vitamin B12 absorption in total gastrectomized ratsEffect of Digestive Enzymes on Bound Vitamin B121Radioactive tracer tests for the recognition and identification of vitamin B12 deficiency statesREFERENCESThe Chemotherapeutic Action of Vitamin B12Intestinal Absorption of Vitamin B 12 in ManDevelopment of Knowledge Concerning the Gastric Intrinsic Factor and Its Relation to Pernicious AnemiaProduction of vitamin B12 by microorganisms and its occurrence in plant tissuesHematopoietic Activity of Glandular Mucoprotein from Human Gastric JuiceHematopoietic Activity (Intrinsic Factor Effect) of Pure Pyloric Secretion from the HogApplication to Human NutritionThe Pathogenesis of Megaloblastic Anaemias and the Value of Vitamin B 12 1 September 1951Volume 35, Issue 3Page: 518-528KeywordsCobalaminsLiver Issue Published: 1 September 1951 PDF downloadLoading ...