THE NATURE OF ITCHING IN DERMATITIC SKIN
Authors: R P ARTHUR, W B SHELLEY
Journal: Annals of Internal Medicine (1958)

Article1 October 1958THE NATURE OF ITCHING IN DERMATITIC SKINROBERT P. ARTHUR, M.D., WALTER B. SHELLEY, M.D., F.A.C.P.ROBERT P. ARTHUR, M.D.Search for more papers by this author, WALTER B. SHELLEY, M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-49-4-900 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptINTRODUCTIONThe purpose of this paper is to present a controlled study of pruritus in dermatitic skin. Recent experimental work has greatly enlarged our knowledge of this troublesome sensation in normal human subjects. A summary of this work will explain the new testing methods developed for use in this report, as well as provide a background understanding of itching mechanisms and responses.Until recently, histamine was the standard material for experimentally inducing a measurable pruritus. The patient's sensitivity was determined by finding the threshold dilution. Indeed, many workers, following Sir Thomas Lewis, considered histamine as the probable direct chemomediator of...Bibliography1. Broadbent JL: Observations on itching produced by cowhage and on the part played by histamine as a mediator of the itch sensation, Brit. J. Pharmacol. 8: 263, 1953. Google Scholar2. ShelleyArthur WBRP: Studies on cowhage (Mucuna pruriens) and its pruritogenic proteinase, mucunain, Arch. Dermat. and Syph. 72: 399, 1955. CrossrefGoogle Scholar3. ArthurShelley RPWB: The role of proteolytic enzymes in the production of pruritus in man, J. Invest. Dermat. 25: 341, 1955. CrossrefMedlineGoogle Scholar4. Ungar G: Biochemical mechanism of the allergic reaction, Internat. Arch. Allergy 4: 258, 1953. CrossrefGoogle Scholar5. Magnus JA: Personal communication, 1955. Google Scholar6. Von Frey M: Zur Physiologie der Juckempfindung, Arch. néerl. de physiol. 7: 142, 1922. Google Scholar7. ShelleyArthur WBRP: The neurohistology and neurophysiology of the itch sensation in man, Arch. Dermat. and Syph. 76: 296, 1957. CrossrefGoogle Scholar8. TomaschBritton JWS: On the individual variability of fiber composition in human peripheral nerve, J. Anat. 90: 337, 1956. MedlineGoogle Scholar9. RajkaKorossyGozony ESM: Zur Pathogenese des Urtikariell entzündlichen Juckens, Dermatologica 112: 1, 1956. CrossrefMedlineGoogle Scholar10. Rothman S: Physiology and biochemistry of the skin, 1954, The University of Chicago Press, Chicago, Illinois. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Philadelphia, Pennsylvania*Received for publication October 21, 1957.From the Department of Dermatology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania.Supported by U. S. Army Research Contract DA-49-007-MD-154 and Smith, Kline & French Laboratories.Requests for reprints should be addressed to Robert P. Arthur, M.D., Clinical Investigator, Medical Research Laboratory, Veterans Administration Hospital, Philadelphia 4, Pennsylvania. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byNeuronal conditions of spinal cord in dermatitis are improved by olopatadineItch and Atopic Dermatitis: An OverviewEyelid dermatitisMeasurement of itchEffects of Skin Contactants on Evolution of Atopic Dermatitis in Children: A Case Control StudyDry Skin and InflammationPathogenesis of eczemaItchThe Role of Pyoderma in PruritusTHE INDUCTION AND ELICITATION OF DISEASE IN HUMAN SKINAtopic DermatitisRESEARCH NEEDS IN 11 MAJOR AREAS IN DERMATOLOGY II. Eczematous and Immunologic DiseasesBiofeedback treatment of atopic dermatitisEMOTIONS AND THE SKIN: THE CONDITIONING OF SCRATCH RESPONSES IN CASES OF ATOPIC DERMATITISAtopic DermatitisThe immunology of allergic skin disease*Proteolytic Enzymes as KininogenasesHaut und NervensystemCutaneous Manifestations of the Malignant Carcinoid Syndrome Severe Pruritus and Orange BlotchesCHARLES E. MENGEL, M.D.Urticaria, Strophulus, Prurigo, PruritusThe Fate of Iontophoretically Introduced Epinephrine and Norepinephrine in Patients with Atopic Dermatitis and in Normal Skin11From the Department of Dermatology, University of Uppsala, Uppsala, Sweden and the Department of Dermatology, University of Pennsylvania School of Medicine, Philadelphia 4, Pa.Dye Clearance and Eccrine Sweat Secretion in Human Skin*STRUCTURES AND PROCESSES INVOLVED IN THE SENSATION OF ITCH 1 October 1958Volume 49, Issue 4Page: 900-908KeywordsAtopic dermatitisDermatologyHistamineProteinsPruritus Issue Published: 1 October 1958 PDF downloadLoading ...