FATAL ADRENAL CORTICAL INSUFFICIENCY PRECIPITATED BY SURGERY DURING PROLONGED CONTINUOUS CORTISONE TREATMENT
Authors: L LEWIS, R F ROBINSON, J YEE, L A HACKER, G EISEN
Journal: Annals of Internal Medicine (1953)

Case Reports1 July 1953FATAL ADRENAL CORTICAL INSUFFICIENCY PRECIPITATED BY SURGERY DURING PROLONGED CONTINUOUS CORTISONE TREATMENTLEON LEWIS, M.D., F.A.C.P., ROBERT F. ROBINSON, M.D., JAMES YEE, M.D., LUCY A. HACKER, M.D., GEORGE EISEN, M.D.LEON LEWIS, M.D., F.A.C.P., ROBERT F. ROBINSON, M.D., JAMES YEE, M.D., LUCY A. HACKER, M.D., GEORGE EISEN, M.D.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-39-1-116 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptINTRODUCTIONWhen hyperadrenocorticism is deliberately induced with ACTH or cortisone for the control of disease, the resulting changes in disease activity are accompanied by a wide variety of physiologic and metabolic changes, some desirable and others unfavorable. Among these are alterations in the function of the anterior pituitary and the adrenal cortex, two endocrine glands of major importance in maintaining the ability of the body to withstand many different types of stress. The increased blood glycocorticoid level which cortisone induces directly and which ACTH produces by adrenal stimulation leads to an inhibition of the output of endogenous ACTH by the...Bibliography1. Editorial: Surgery in patients with cortisone-induced adrenal insufficiency, J. A. M. A. 148: 1422 (April 19) 1952. CrossrefGoogle Scholar2. Engel FL: Comparative effects of ACTH and stress in nitrogen metabolism, Proceedings of the Second Clinical ACTH Conference, Vol. 1, Mote, J. R., Editor, 1951, Blakiston Co., New York, pp. 235-241. Google Scholar3. Lewis CJ: Adrenal and pancreatic hemorrhage following operation, Brit. M. J. 2: 706, 1921. Google Scholar4. Kelly JF: Hemorrhage of supradrenal glands following breech extraction, J. Indiana M. A. 24: 135, 1931. Google Scholar5. Selye H: The physiology and pathology of exposure to stress, pp. 99 et seq., 1950. Acta, Inc., Montreal. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: *Received for publication October 11, 1952.From the Kabat-Kaiser Institute, Vallejo, California.Grateful acknowledgment is made to Meyer Friedman, M.D., and H. R. Fishback, M.D., for autopsy material. 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ABBOTT, M.D., HARVEY KRIEGER, M.D., STANLEY LEVEY, Ph.D.Management of Adrenocortical InsufficiencyRelation of ACTH and Cortisone to InfectionThe Use of Corticotropin, Cortisone and Hydrocortisone in General Surgery 1 July 1953Volume 39, Issue 1Page: 116-126KeywordsAdrenal cortexAdrenocorticotropic hormoneAutopsyBloodEndocrine physiologyMetabolic disordersSurgery ePublished: 1 December 2008 Issue Published: 1 July 1953 PDF downloadLoading ...