Some Physiological and Biochemical Aspects of Deficiencies with Special Reference to Vitamin B
Authors: George R. Cowgill
Journal: Annals of Internal Medicine (1929)

Article1 September 1929Some Physiological and Biochemical Aspects of Deficiencies with Special Reference to Vitamin BGEORGE R. COWGILLGEORGE R. COWGILLSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-3-3-230 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptMuch of the support for the vitamin hypothesis has come from the experimental laboratory of students of nutrition. The pioneer work in this field, however, had a clinical origin centering around the disease beri-beri. In his monographic study of this disorder Vedder (1913) championed the idea that the primary etiologic factor is lack of a vitamin substance. Many clinicians, however, especially among the Japanese (Ogato et al, 1923) hesitate to concur in this opinion, because experimental beri-beri in animals differs in certain respects from human beri-beri as seen in the clinic. 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