tbuckley/cabot-search huggingface dataset:
Abstract 11032: Home Exercise Reduces Hopelessness in Patients with Coronary Heart Disease
Authors: Susan L Dunn, Maureen Dunn, Nicole Rieth, Jacob Clark, Nathan Tintle
Journal: Circulation (2014)

Background: In patients with coronary heart disease (CHD) the presence of hopelessness is associated with increased morbidity and mortality, independent of depression. To date few studies have examined the effects of interventions, such as exercise, in reducing hopelessness in CHD patients. It is well established that some form of regular exercise improves mental health and mood in the general population.

Purpose and Methods: Using a longitudinal design the purpose of this study was to determine the effects of regular exercise on hopelessness levels in patients with CHD (N= 324). Subjects completed the State-Trait Hopelessness Scale and an exercise questionnaire measuring the frequency of walking or biking in a home or hospital setting. Mixed effects models were used to evaluate the relationship between hopelessness levels and exercise over one year.

Results: For subjects with little/no or mild baseline hopelessness, state and trait hopelessness levels were not significantly different over the year between exercisers and non-exercisers. However, among subjects with moderate to severe baseline hopelessness, regular (≥3 days/week) exercise at home compared to minimal or no exercise predicted significantly lower state (Non-exercisers: M= 2.17, SE= 0.05, N= 148; Exercisers: M= 1.91, SE= 0.05, N= 131; p= 0.002,) and trait (Non-exercisers: M= 2.02, SE= 0.04, N= 177; Exercisers: M= 1.79, SE= 0.04, N= 142; p= 0.01) hopelessness. Hospital exercise was not associated with significant changes in state or trait hopelessness. In a multivariable model of subjects with moderate to severe baseline hopelessness, home exercise remained significantly predictive of decreased state hopelessness after adjusting for hospital exercise, depression, and demographic variables. Neither exercise type was related to decreased trait hopelessness in a multivariable model.

Conclusion: This study demonstrates for the first time the beneficial effect of regular home exercise on decreasing moderate to severe hopelessness in CHD patients. It is therefore important to encourage patients with moderate to severe hopelessness to participate in some type of regular exercise. Further research is needed to evaluate how patients with hopelessness can be motivated to exercise at home.
Dichotomous Regulation of Myosin Phosphorylation and Shape Change by Rho-Kinase and Calcium in Intact Human Platelets
Authors: Markus Bauer, Michaela Retzer, Jonathan I. Wilde, Petra Maschberger, Markus Essler, Martin Aepfelbacher, Steve P. Watson, Wolfgang Siess
Journal: Blood (1999)
Cancer Researchers Target Angiogenesis
Authors: Tracy Hampton
Journal: JAMA (2003)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Abstract P298: Relationship Of Plasma Asymmetrical Dimethylarginine To Carotid Intima-media Thickness In General Japanese Population: The ERA-JUMP And The SESSA
Authors: Shin-ya Nagasawa, Katsuyuki Miura, Akira Fujiyoshi, Aya Kadota, Takayoshi Ohkubo, Takashi Hisamatsu, Sayaka Kadowaki, Naoko Miyagawa, Sayuki Torii, Maryam Zaid, Kamal Masaki, Emma J Barinas-Mitchell, Marrianne H Bertolet, Rhobert W Evans, Aiman El-Saed, Lewis H Kuller, Akira Sekikawa, Hirtsugu Ueshima
Journal: Circulation (2014)

Objective: Asymmetrical dimethylarginine (ADMA), an endogenous nitric oxide synthase inhibitor, is known as a mediator of endothelial cell dysfunction. Some clinical studies have found evidence that increased plasma ADMA levels are associated with a higher risk of cerebrovascular events. However, studies on the relationship of plasma ADMA to subclinical atherosclerosis have been scarce. We evaluated the association of ADMA with carotid intima-media thickness (IMT) in population-based samples in Japan. Methods: Population-based Japanese samples composed of 313 men aged 40-49 (40s men) from the ERA-JUMP and 732 men aged 60-79 (60s+70s men) from the SESSA were examined with physical examinations, life-style questionnaires, laboratory assessment and IMT using standardized methods. Plasma samples were stored at -80°C, and concentration of ADMA was determined using a validated high-throughput liquid chromatographic-tandem mass spectrometric assay. The IMTs of the right and left common carotid arteries, the carotid bulbs, and the internal carotid arteries were examined. Statistical associations were evaluated using multiple linear regression models with adjustment for age, body mass index, systolic blood pressure, LDL-cholesterol, HDL-cholesterol, fasting blood glucose, smoking, alcohol intake, medications for hypertension, hyperlipidemia, or diabetes, and estimated glomerular filtration rate (eGFR) . Results: The average concentrations and standard deviation (SD) of plasma ADMA in men aged 40-49 and 60-79 were 0.39 ± 0.06 and 0.43 ± 0.06 μmol/L, respectively. The mean and SD of IMT in men aged 40-49 and 60-79 were 0.61 ± 0.07 and 0.91 ± 0.20 mm, respectively. Higher level of ADMA was significantly and positively associated with proportion of current smoking both in 40s and 60s+70s men (correlation coefficient: both p &lt;0.001). It was also significantly and positively associated with eGFR in 60s+70s men (p &lt;0.001) but not associated with eGFR in 40s men (p = 0.429). In full adjusted linear regression models, 1 SD increase in ADMA was associated with 0.14mm increase in IMT in 40s men (p=0.01) but only 0.04mm increase in IMT in 60s+70s men (p=0.26). Conclusions: Higher level of ADMA was associated with more IMT independently of traditional risk factors and renal function in young adult men, but not in elderly men.
Rho proteins and the p38-MAPK pathway are important mediators for LPS-induced interleukin-8 expression in human endothelial cells
Authors: Stefan Hippenstiel, Saskia Soeth, Birgit Kellas, Oliver Fuhrmann, Joachim Seybold, Matthias Krüll, Christoph v. Eichel-Streiber, Matthias Goebeler, Stephan Ludwig, Norbert Suttorp
Journal: Blood (2000)
Hepatitis C virus infection, HBsAg carrier state and hepatocellular carcinoma
Authors: T. Stroffolini, M. Chiaramonte, C. Tiribelli, E. Villa, R.G. Simonetti, M. Rapicetta, M.A. Stazi, T. Bertin, S.L. Crocè, P. Trande, A. Magliocco, P. Chionne
Journal: Journal of Hepatology (1992)
MENINGOCOCCIC INFECTIONS WITH SPECIAL REFERENCE TO CERTAIN DIAGNOSTIC CONSIDERATIONS; AN ANALYSIS OF THIRTY-SEVEN CASES
Authors: Albert C. Oxman, Isidore Fischer
Journal: Annals of Internal Medicine (1945)

Article1 December 1945MENINGOCOCCIC INFECTIONS WITH SPECIAL REFERENCE TO CERTAIN DIAGNOSTIC CONSIDERATIONS; AN ANALYSIS OF THIRTY-SEVEN CASESALBERT C. OXMAN, ISIDORE FISCHERALBERT C. OXMANSearch for more papers by this author, ISIDORE FISCHERSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-23-6-924 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe comprehensive study of meningococcic meningitis and septicemia by Colonel Henry M. Thomas, Jr.,1concerns a total of 1,518 cases which occurred in the Fourth Service Command during the winter and spring of 1942-1943. The mortality rate of 8.8 per cent in the first 317 cases was lowered to 2.1 per cent in the last 761 cases. These rates are to be compared with the rate of 39 per cent in something less than 6,000 cases in the United States Army in 33 months during the First World War, and with civilian reports (cited by Thomas) in which a mortality...Bibliography1. THOMAS HM: Meningococcic meningitis and septicemia. Report of outbreak in Fourth Service Command during Winter and Spring of 1942-1943, Jr. Am. Med. Assoc., 1943, cxxiii, 264-272. CrossrefGoogle Scholar2. SAMPSON BF: Resistance of the new recruit (Letters to the Editor), Lancet, 1941, i, 772-773. CrossrefGoogle Scholar3. COPEMAN WS: Meningococcal septicaemia, Brit. Med. Jr., 1942, i, 760-761. CrossrefGoogle Scholar4. ADAMS FD: Some clinical aspects of meningococcic infection, Ann. Int. Med., 1944, xx, 33-40. Google Scholar5. DICKSONMCKINNONMAGNERMCGILLIVRAY RCNEDNB: Meningococcal infection; report of 50 cases, 40 treated with serum and 10 treated with serum and sulfanilamide, Lancet, 1941, ii, 631-634. CrossrefGoogle Scholar6. WEIRVAUTIER TWCK: Mental symptoms in cerebrospinal meningitis, Brit. Med. Jr., 1942, i, 179-181. CrossrefGoogle Scholar7. KILHAM L: Meningococcal septicaemia with a malarial type of fever, Brit. Med. Jr., 1942, ii, 696. CrossrefGoogle Scholar8. CAMPBELL EP: Meningococcal meningitis, Ann. Int. Med., 1942, xvi, 694-700. LinkGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: *Received for publication April 2, 1945.From the Medical Service, Station Hospital, Camp Bowie, Texas. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byMeningococcic pericarditisREFERENCES 1 December 1945Volume 23, Issue 6Page: 924-934KeywordsCyclic adenosine monophosphateDeath ratesMedical servicesMeningitisMeningococcal diseaseMortalitySepsis ePublished: 1 December 2008 Issue Published: 1 December 1945 PDF downloadLoading ...
517. Prevention of Onset of Parkinson's Disease by In Vivo Gene Transfer of Human Hepatocyte Growth Factor in Primate Model: A Model of Gene Therapy for Parkinson's Disease
Authors: Hinrich Staecker, Mark Praetorius, Kim Baker, Douglas E. Brough
Journal: Molecular Therapy (2004)

Over expression of math1 has been demonstrated to induce generation of hair cells in the cochlea in neonatal tissue culture models of the organ of Corti and math 1 generation of hair cells has recently been shown in vivo. We have examined an in vitro organtypic culture model as well as unilateral acute and bilateral chronic models of aminoglycoside vestibular injury. Delivery of Math1 using an adenovector (Ad) resulted in the generation of hair cells in adult mouse utriclular and saccular cultures. Mice treated acutely or chronically with aminoglycosides showed recovery of a significant portion of the vestibular neuroepithelium after AdMath1.11D was infused into the inner ear. Interestingly there was no recovery of hair cells noted within the cochlea in these mouse models and no hair cells noted outside of the vestibular neuroepithelium. Assessment of animals 2 months after vector infusion demonstrated a recovery of swim times compared to non-vector treated controls, demonstrating recovery of vestibular function after Math1 gene delivery.
Familial Pseudohyperkalemia Maps to the Same Locus as Dehydrated Hereditary Stomatocytosis (Hereditary Xerocytosis)
Authors: A. Iolascon, G.W. Stewart, J.F. Ajetunmobi, S. Perrotta, J. Delaunay, M. Carella, L. Zelante, P. Gasparini
Journal: Blood (1999)
THE EFFECT OF HORMONES ON CELLULAR PERMEABILITY
Authors: Ernst Gellhorn
Journal: Annals of Internal Medicine (1933)

ExcerptHormone action and nervous action (involving the central and the autonomic nervous systems) are the two important mechanisms of bringing about the adjustment of the organism to its surroundings. Excitatory and inhibitory influences are exerted on the various organs of the body resulting in adaptive coördination. The nervous and the hormone mechanism cooperate, as has been shown for example in Cannon's extensive studies.1The effects of the discharges of the sympathetic such as occur in rage are enhanced by the liberation of adrenalin. The distribution of the nerves over the whole body and the excitation of large groups of nerves...
Benzoquinone-induced inhibition of DNA topoisomerase II.
Authors: Jack C. Yalowich, Elliot Asare, Angela Giorgianni
Journal: Cancer Research (2006)

5531  Previous publications by other groups have suggested that benzene metabolites function as DNA topoisomerase II (topo II) poisons in isolated enzyme systems and in intact cells (Biochemistry 43: 7563–74, 2005; Chem Res Toxicol 18: 761–70, 2005). We now provide experimental evidence to indicate that a variety of quinones including 1,4 benzoquinone (BQ) function to both poison topo II and inhibit catalytic activity of the enzyme. BQ was found to induce topo II-mediated cleavage (linearization) and strand passage (relaxation) of supercoiled pBR322 at concentrations as low as 2 μM. These same results were obtained using 5–20 μM 1,2- and 1,4-napthoquinones, and 200-1000 μM 1,4 hydroquinone (HQ). Preincubation with 500 μM DTT and GSH prevented both DNA cleavage and inhibition of strand passage whereas addition of EDTA prior to denaturation with SDS only prevented DNA cleavage. These results suggested that these quinones inhibited topo II catalytic activity (strand passage) through reaction with sulfhydryl groups on topo II cysteines. Using a fluorescent maleimide compound, Thio-Glo-1 (TG), to label cysteine sulhydryl groups (SH) on purified topo IIα, we confirmed that BQ and the napthoquinones prevented topo II SH group labeling. Using leukemia K562 cells and an etoposide-resistant K/VP.5 clone containing reduced topo II levels, 2–3 fold cross resistance to both BQ and HQ was observed. In contrast, there was no cross resistance to a synthetic vitamin K quinone analog, compound 5, which is known to target Cdc25 phosphatases. Depletion of intracellular GSH with BSO potentiated antiproliferative effects of BQ and HQ but not compound 5. In addition, oxidative stress (as assessed by dichlorofluorescein fluoresecence) was induced by BQ but not by compound 5 in K562 cells. Finally, formation of BQ-induced topo II-DNA covalent complexes were reduced in K/VP.5 compared to K562 cells. Together results confirm that BQ targets topo II in cells and is capable of both poisoning topo II to induce strand breaks and inhibiting its catalytic activity through interaction with enzyme SH groups. These results have important implications for better understanding the basis for benzene-induced leukemogenesis. Support: RO1 CA90787
Immunologic Response to Lymphocytic Choriomeningitis Virus in Lethally Irradiated Mice Treated With Bone Marrow
Authors: Delta E. Uphoff, Victor H. Haas
Journal: JNCI Journal of the National Cancer Institute (1960)

Journal Article Immunologic Response to Lymphocytic Choriomeningitis Virus in Lethally Irradiated Mice Treated With Bone Marrow Get access Delta E. Uphoff, Delta E. Uphoff Search for other works by this author on: Oxford Academic PubMed Google Scholar Victor H. Haas Victor H. Haas Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 25, Issue 4, October 1960, Pages 779–786, https://doi.org/10.1093/jnci/25.4.779 Published: 01 October 1960 Article history Received: 04 April 1960 Published: 01 October 1960
Blood Transfusion in Patients With Acute Coronary Syndrome
Authors: Saif S. Rathore, Martha J. Radford, Harlan M. Krumholz
Journal: JAMA (2005)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Child Psychiatry and Pediatrics
Authors: M B Rothenberg
Journal: New England Journal of Medicine (1982)

Anders9 survey,  report of which appears in this issue of Pediatrics (p. 616), was much needed, and I am grateful to him for it. The data that he presents certainly reflect my own experience in three major training centers during  last 25 years.  I have some trouble with his contention that the source of  difficulty stems from  fact that neither child psychiatrists nor behavioral pediatricians have defined their areas of collaborative responsibility and effectiveness sufficiently. Also, I am not comfortable with his recommended solution to this problem.  The American tendency to stand in awe of  scientific, especially on a molecular level, leaves many pediatric faculty members with a conscious or unconscious feeling that they would somehow lose prestige and status were they to focus their teaching efforts in  behavioral pediatrics arena.1
Insomniac Artists Explore Night's Terrain
Authors: Lynne Lamberg
Journal: JAMA (2003)

WASHINGTON, DC—A mock bedroom draws viewers into the world of the insomniac. The neatly made bed looks welcoming, but it is too flimsy to sleep on. Assembled from cardboard boxes, with sheets and bed skirt fashioned from plastic garbage bags and newspapers, the bed testifies to its creator’s fragile nights. A quilt lays bare the loneliness and longing that stalk the wakeful artist, or perhapsmerelyher fictivealter-ego.Bonnie Lee Holland stitched together clippings from newspapers she perused on sleepless nights—a patchwork of advertisements fordatingservices,cruiseships, and liposuction, and articles on relationships, aging, and weight loss. A nightstand rests on a stack of romance novels, its top displaying a game of chance, with a single male figure at its center. Holland’s work, Bedroom Version III (1997-2002), is one of 53 multimedia works by 31 artists, all women, included in Insomnia: Landscapes of the Night, an exhibit at the National Museum of Women in the Arts (NMWA). The show, here through November 30, 2003, is housed in dusky blue galleries with subdued lighting that fosters a contemplative, albeit doleful mood.
Estimating leukemia-free survival after allografting for chronic myeloid leukemia: a new method that takes into account patients who relapse and are restored to complete remission
Authors: Charles Craddock, Richard M. Szydlo, John P. Klein, Francesco Dazzi, Eduardo Olavarria, Frits van Rhee, Christopher Pocock, Kate Cwynarski, Jane F. Apperley, John M. Goldman
Journal: Blood (2000)
Snow, Boulevard de Clichy, Paris
Authors: M. Therese Southgate
Journal: JAMA (2000)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Abstract 3707: The multitargeted kinase inhibitor dasatinib induces DNA damage, Hippo pathway engagement and senescence in lung cancer cell lines that possess kinase-inactivating BRAF mutations
Authors: Banibrata Sen, Shaohua Peng, Tuhina Mazumdar, Lauren A. Byers, Humam Kadara, Faye M. Johnson
Journal: Cancer Research (2014)

Abstract Non-small cell lung cancer (NSCLC) is the leading cause of cancer-related death. Therapies that target specific genetic aberrations are very effective in a subset on NSCLC. An effective approach for discovering novel therapeutic targets is to characterize responsive tumors. In this regard, we discovered a novel, kinase-inactivating BRAF mutation in the tumor of a patient with a marked and durable response to the multi-targeted kinase inhibitor dasatinib. Likewise, dasatinib induces senescence in NSCLC cells with endogenous kinase-inactivating BRAF mutations (KIBRAF). To identify the mechanism underlying this effect, we used reverse phase protein array, Western blotting and gene expression analysis on NSCLC cell lines with KIBRAF or WTBRAF incubated with dasatinib. We found that ATM, ATR, Rad 51, pH2AX, CDC6, CHEK1 (Chk1), pLATS and TAZ, were differentially regulated in mutant vs. WT cell lines. Quantitative real-time PCR analysis revealed that CHEK1, TAZ and TAZ's downstream targets were decreased following incubation with dasatinib in KIBRAF cells. Overexpression of CHEK1 or TAZ in KIBRAF NSCLC cells resulted in dasatinib resistance and decreased dasatinib-induced senescence. Given the differential effect on CHEK1 and pH2AX, we studied the effect of dasatinib on DNA damage using the COMET assay and found that dasatinib induces a significant increase in COMET-positive KIBRAF NSCLC cells. These data suggest that the inhibition of Chk1 along with inhibition of Hippo pathway results in the dasatinib sensitivity in NSCLC with KIBRAF. Citation Format: Banibrata Sen, Shaohua Peng, Tuhina Mazumdar, Lauren A. Byers, Humam Kadara, Faye M. Johnson. The multitargeted kinase inhibitor dasatinib induces DNA damage, Hippo pathway engagement and senescence in lung cancer cell lines that possess kinase-inactivating BRAF mutations. [abstract]. In: Proceedings of the 105th Annual Meeting of the American Association for Cancer Research; 2014 Apr 5-9; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2014;74(19 Suppl):Abstract nr 3707. doi:10.1158/1538-7445.AM2014-3707