tbuckley/cabot-search huggingface dataset:
Effectiveness of a Statewide Abusive Head Trauma Prevention Program in North Carolina
Authors: Adam J. Zolotor, Desmond K. Runyan, Meghan Shanahan, Christine Piette Durrance, Maryalice Nocera, Kelly Sullivan, Joanne Klevens, Robert Murphy, Marilyn Barr, Ronald G. Barr
Journal: JAMA Pediatrics (2015)

Abusive head trauma (AHT) is a serious condition, with an incidence of approximately 30 cases per 100,000 person-years in the first year of life.To assess the effectiveness of a statewide universal AHT prevention program.In total, 88.29% of parents of newborns (n = 405 060) in North Carolina received the intervention (June 1, 2009, to September 30, 2012). A comparison of preintervention and postintervention was performed using nurse advice line telephone calls regarding infant crying (January 1, 2005, to December 31, 2010). A difference-in-difference analysis compared AHT rates in the prevention program state with those of other states before and after the implementation of the program (January 1, 2000, to December 31, 2011).The Period of PURPLE Crying intervention, developed by the National Center on Shaken Baby Syndrome, was delivered by nurse-provided education, a DVD, and a booklet, with reinforcement by primary care practices and a media campaign.Changes in proportions of telephone calls for crying concerns to a nurse advice line and in AHT rates per 100,000 infants after the intervention (June 1, 2009, to September 30, 2011) in the first year of life using hospital discharge data for January 1, 2000, to December 31, 2011.In the 2 years after implementation of the intervention, parental telephone calls to the nurse advice line for crying declined by 20% for children younger than 3 months (rate ratio, 0.80; 95% CI, 0.73-0.87; P < .001) and by 12% for children 3 to 12 months old (rate ratio, 0.88; 95% CI, 0.78-0.99; P = .03). No reduction in state-level AHT rates was observed, with mean rates of 34.01 person-years before the intervention and 36.04 person-years after the intervention. A difference-in-difference analysis from January 1, 2000, to December 31, 2011, controlling for economic indicators, indicated that the intervention did not have a statistically significant effect on AHT rates (β coefficient, -1.42; 95% CI, -13.31 to 10.45).The Period of PURPLE Crying intervention was associated with a reduction in telephone calls to a nurse advice line. The study found no reduction in AHT rates over time in North Carolina relative to other states. Consequently, while this observational study was feasible and supported the program effectiveness in part, further programmatic efforts and evaluation are needed to demonstrate an effect on AHT rates.
Traditional Cardiovascular Risk Factors in Relation to Left Ventricular Mass, Volume, and Systolic Function by Cardiac Magnetic Resonance Imaging
Authors: Susan R. Heckbert, Wendy Post, Gregory D.N. Pearson, Donna K. Arnett, Antoinette S. Gomes, Michael Jerosch-Herold, W. Gregory Hundley, Joao A. Lima, David A. Bluemke
Journal: Journal of the American College of Cardiology (2006)
Mortality in acute patients treated with noninvasive ventilation (NIV)
Authors: Virginia Almadana, Ana Gόmez-Bastero, Agustín Valido, Jesus Sánchez, Patricia Guerrero, Teodoro Montemayor
Journal: European Respiratory Journal (2011)

Objective: To evaluate the mortality of patients with NIV,in a general way and by disease and to determine whether there are differences between the group that survives against the group that passes away.

Methods: We evaluated patients in acute respiratory failure and treated with NIV in our hospital from 2008 to 2010.General data,blood gases,pathology and treatment criteria were analyzed and compared.

Results: n=598.Overall mortality was 17.8%.The mortality related to respiratory failure was 11.3%. In a subgroup of 170 patients,we analyzed whether the NIV was carried out due to clinical-gasometric criteria,limitation of therapeutic effort (LTE, without intensive care unit admission criteria) or palliative criteriaWe find significant differences between groups,showing that more than 1/2 of the deceased (66%) had a palliative criteria.The mortality of LTE was approximately 1 out of 4.Mortality from pathology was (% of the total for each pathology): COPD (11%) with or without other pathology (6%) vs (4%), interstitial lung disease (55%), OHS (5.2%), kyphoscoliosis (17%), heart failure (16%) and neuromuscular disease (41%).When comparing epidemiological data, comorbidities, pH,PCO2 and side effects between the group died and those who survived after treatment, we founded significant differences in the deceased group:older,less obese.

Conclusions: -It is necessary to permormance a detailed analysis of mortality in each group of pathology.In COPD and OHS, which are the most ventilated, it is quite worthwhile to carry out NIV.-The palliative patients group increase mortality rates so it is very important to analyze this group separately.-To carry out NIV may be an alternative for patients who do not fulfil ICU admission criteria.
Clinical course and outcome of vasculitis related interstitial lung disease
Authors: Bo Young Lee, Sang Min Lee, Joon Seon Song, Jin Woo Song
Journal: European Respiratory Journal (2014)

Backgrounds:  Systemic vasculitis is known to show variable lung manifestations such as diffuse alveolar hemorrhage, nodule, bronchial stenosis and pulmonary fibrosis. However, clinical features, courses and outcome of vasculitis related interstitial lung disease (Vasculitis-ILD) have not well been defined. The aim of our study was to investigate clinical course and outcome of Vasculitis-ILD.   Methods:  Vasculitis was confirmed in 119 patients in Asan Medical Center, Seoul, Korea. Among them, those with ILD (14 patients, 12%) were included in this study. We retrospectively analyzed their clinical features, course and outcome using medical records and the record of National Health Insurance of Korea.   Results:  The median follow-up period was 14 months. Mean age was 60 ± 13 years, female was 57%, and smoker was 57% (current: 21%, ex-smoker: 36%). Microscopic polyarteritis was the most common (71%), followed by polyarteritis nodosa (21%) and Wegener9s granulomatosis (7%). Myeloperoxidase antineutrophil cytoplasmic antibody (MPO-ANCA) was detected in 11 (85%) patients. Usual interstitial pneumonia (UIP) was the most common pattern seen on high resolution computed tomography (57%) and surgical lung biopsy (50%). Most of the subjects (n=13) were treated with prednisolone and the mean dose was 39 mg. After treatment, 8 patients (62%) showed stabilized lung function, but the others showed progression of the disease. The subjects had poorer outcome compared with those without lung involvement (1-year survival: 69% vs. 93%; p=0.015).   Conclusion:  Microscopic polyarteritis and UIP pattern was the most common in Vasculitis-ILD. Prognosis of patients with pulmonary fibrosis was poorer than those without.
SRC3 Phosphorylation at Serine 543 Is a Positive Independent Prognostic Factor in ER-Positive Breast Cancer
Authors: Wilbert Zwart, Koen D. Flach, Bharath Rudraraju, Tarek M.A. Abdel-Fatah, Ondrej Gojis, Sander Canisius, David Moore, Ekaterina Nevedomskaya, Mark Opdam, Marjolein Droog, Ingrid Hofland, Steve Chan, Jacqui Shaw, Ian O. Ellis, R. Charles Coombes, Jason S. Carroll, Simak Ali, Carlo Palmieri
Journal: Clinical Cancer Research (2015)

The steroid receptor coactivator SRC3 is essential for the transcriptional activity of estrogen receptor α (ERα). SRC3 is sufficient to cause mammary tumorigenesis, and has also been implicated in endocrine resistance. SRC3 is posttranslationally modified by phosphorylation, but these events have not been investigated with regard to functionality or disease association. Here, we investigate the spatial selectivity of SRC3-pS543/DNA binding over the human genome and its expression in primary human breast cancer in relation with outcome.
Abstract 18366: Cutoff of 1.0 cm2 For Severe Aortic Stenosis? A Case for Redefining this Cutoff Based on Eccentricity of LVOT Geometry
Authors: Praveen Mehrotra, Gary Mak, Katrijn Jansen, Xin Zeng, Aidan Flynn, Jon Passeri, Judy Hung
Journal: Circulation (2011)

Background: Current guidelines define severe aortic stenosis (AS) as aortic valve area (AVA) of <1.0 cm2. This cutoff is based on the assumption of a circular left ventricular outflow tract (LVOT) ...
Hereditary Nonpolyposis Colorectal Cancer: A Call for Attention
Authors: Sapna Syngal
Journal: Journal of Clinical Oncology (2000)

Article Tools EDITORIAL Article Tools OPTIONS & TOOLS Export Citation Track Citation Add To Favorites Rights & Permissions COMPANION ARTICLES No companion articles ARTICLE CITATION DOI: 10.1200/JCO.2000.18.11.2189 Journal of Clinical Oncology - published online before print September 21, 2016 PMID: 10829037 Hereditary Nonpolyposis Colorectal Cancer: A Call for Attention Sapna Syngal, MD, MPHxSapna SyngalSearch for articles by this author Show More Brigham and Women’s Hospital, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA https://doi.org/10.1200/JCO.2000.18.11.2189 First Page Full Text PDF Figures and Tables © 2000 by American Society of Clinical Oncology
Lymphoid Cell-Culture Line Derived From Lymph Node of Marmoset Infected With &lt;italic&gt;Herpesvirus saimiri&lt;/italic&gt;—Preliminary Report
Authors: Alan S. Rabson, Gregory T. O'Conor, Douglas E. Lorenz, Ruth L. Kirschstein, Frances Y. Legallais, Tommie S. Tralka
Journal: JNCI Journal of the National Cancer Institute (1971)

A lymphoid cell line (MLC-1) which grows in suspension culture has been derived from the lymph node of a marmoset infected with Herpesvirus saimiri, a virus of squirrel monkeys producing a lethal disease in marmosets with histological features of malignant lymphoma. Three months after initiation of the cultures, only rare MLC-1 cells containing intranuclear herpesvirus particles were found by electron microscopy, and virus could not be isolated from frozen and thawed MLC-1 cell pellets or culture supernatants. When living MLC-1 cells were cocultivated with Vero monkey kidney cell cultures, however, a virus with morphological characteristics of a herpesvirus was readily isolated. Five months after initiation of the MLC-1 cultures, small amounts of this virus could also be recovered intermittently from supernatants. This herpesvirus, however, produced smaller plaques than H. saimiri and, by neutralization tests, appeared to be related to, though not identical with, H. saimiri. When inoculated into marmosets, it produced a lethal disease similar to that produced by H. saimiri but with more necrosis and less lymphoreticular cell proliferation. It may represent a variant of H. saimiri or a related marmoset herpesvirus. Its relationship to previously described herpesviruses and its role in lymphoreticular cell proliferation remain to be determined.
Pathogenesis of Avian Lymphoid Leukosis. II. Immunologic Reactivity During Lymphomagenesls<xref ref-type="fn" rid="FN2">2</xref>
Authors: P. B. Dent, M. D. Cooper, L. N. Payne, J. J. Solomon, B. R. Burmester, R. A. Good
Journal: JNCI Journal of the National Cancer Institute (1968)

The immunologic competence of chickens infected with avion leukosis virus (strain RPL-12) was studied. Circulating γ-globulin levels, natural agglutinins, and humoral responses to a variety of antigens were measured. Cellular immunity was assessed by graft rejection and graft-versus-host reactivity of peripheral leukocytes. Infection at hatching with the oncogenic virus caused no significant impairment in immunologic reactivity by any parameter measured. The apparent disparity between these results and those previously reported was thought to be due to the increased age of the birds at time of testing in this study as well as to the unusually low mortality from leukosis. Those birds that eventually died from disseminated leukosis had an impaired ability to produce antibody against bovine serum albumin and Brucella abortus. Infected birds attained adult levels of IgG more rapidly than controls, but otherwise showed no difference either in IgG or IgM levels. RSV-neutralizing antibody was found in 50% of infected birds. Immunohistochemical studies of the disseminated tumor indicated that it did not produce immunoglobulin. The significance of these findings is discussed in terms of the role of alterations in immunologic reactivity in the pathogenesis of this and other experimental malignancies.
CD6+ Donor Marrow T-Cell Depletion as the Sole Form of Graft-Versus-Host Disease Prophylaxis in Patients Undergoing Allogeneic Bone Marrow Transplant From Unrelated Donors
Authors: Robert J. Soiffer, Edie Weller, Edwin P. Alyea, Peter Mauch, Iain L. Webb, David C. Fisher, Arnold S. Freedman, Robert L. Schlossman, John Gribben, Stephanie Lee, Kenneth C. Anderson, Karen Marcus, Richard M. Stone, Joseph H. Antin, Jerome Ritz
Journal: Journal of Clinical Oncology (2001)

PURPOSE: The role of donor marrow T-cell depletion (TCD) in preventing graft-versus-host disease (GVHD) after transplantation of unrelated allogeneic marrow remains undefined. Because different TCD methodologies differ in the degree and specificity with which T cells are removed, it is likely that transplant outcomes would depend on which technique is used. Herein, we report results in the first 48 recipients of unrelated marrow using CD6+ TCD as the sole form of GVHD prophylaxis. PATIENTS AND METHODS: Median age of patients was 46 years (20 to 58 years). Donors were matched at A/B HLA loci. Ablation consisted of cyclophosphamide and fractionated total-body irradiation (TBI; 14 Gy). To facilitate engraftment, patients also received 7.5 Gy (22 points) or 4.5 Gy (26 points) of total lymphoid irradiation (TLI) before admission. No additional immune suppressive prophylaxis was administered. Granulocyte colony-stimulating factor was administered daily from day +1 to engraftment. RESULTS: All 48 patients demonstrated neutrophil engraftment. An absolute neutrophil count of 500 × 10 6 /L was achieved at a median of 12 days (range, 9 to 23 days). There were no cases of late graft failure. The number of CD34+ cells infused/kg was associated with speed of platelet and neutrophil recovery. The dose of TLI did not influence engraftment. Grades 2-4 acute GVHD occurred in 42% of patients (95% confidence interval [CI], 0.28 to 0.57). Mortality at day 100 was 19%. There have been only five relapses. Estimated 2-year survival was 44% (95% CI, 0.28 to 0.59) for the entire group, 58% for patients less than 50 years of age. In multivariable analysis, age less than 50 years (P = .002), cytomegalovirus seronegative status (P = .04), and early disease status at bone marrow transplant (P = .05) were associated with superior survival. CONCLUSION: CD6+ TCD does not impede engraftment of unrelated bone marrow after low-dose TLI, cyclophosphamide, and TBI. CD6+ TCD as the sole form of GVHD prophylaxis results in an incidence of GVHD that compares favorably with many adult studies of unrelated transplantation using unmanipulated marrow and immune-suppressive medications, especially in light of the median age of our patients (46 years). Although event-free survival in patients less than 50 years of age is very encouraging, older patients experience frequent transplantation-related complications despite TCD.
Hemodynamic Tolerance of Intermittent Hemodialysis in Critically Ill Patients
Authors: FRÉDÉRIQUE SCHORTGEN, NADINE SOUBRIER, CHRISTOPHE DELCLAUX, MARIE THUONG, EMMANUELLE GIROU, CHRISTIAN BRUN-BUISSON, FRANÇOIS LEMAIRE, LAURENT BROCHARD
Journal: American Journal of Respiratory and Critical Care Medicine (2000)

Poor hemodynamic tolerance of intermittent hemodialysis (IHD) is a common problem for patients in an intensive care unit (ICU). New dialysis strategies have been adapted to chronic hemodialysis patients with cardiovascular insufficiency. To improve hemodynamic tolerance of IHD, specific guidelines were progressively implemented into practice through the year 1996 in our 26-bed medical ICU. To evaluate the efficiency of these guidelines we retrospectively compared all IHD performed during the years before (1995) and after (1997) implementation of these recommendations. Forty-five patients underwent 248 IHD sessions in 1995 and 76 patients underwent 289 IHD sessions in 1997. The two populations were similar for age, sex, chronic hemodialysis (26% versus 17%), and secondary acute renal failure. In 1997, patients were more severely ill with a higher SAPS II (50 +/- 17 versus 59 +/- 24; p = 0.036), and more patients required epinephrine or norepinephrine infusion before dialysis sessions (16% versus 34%; p < 0.0001). The compliance to guidelines was high, inducing a significant change in IHD modalities. As a result, hemodynamic tolerance was significantly better in 1997, with less systolic blood pressure drop at onset (33% versus 21%, p = 0. 002) and during the sessions (68% versus 56%, p = 0.002). IHD with hypotensive episode or need for therapeutic interventions were less frequent in 1997 (71% versus 61%, p = 0.015). The ICU mortality was similar (53.3% in 1995 versus 47.3% in 1997; p = 0.52) but death rate in 1997, but not in 1995, was significantly less than predicted from SAPS II (47.3% versus 65.6%; p = 0.02). Length of ICU stay was also reduced for survivors in 1997 (p = 0.04). Implementation of practice guidelines for intermittent hemodialysis in ICU patients lessens hemodynamic instability and may improve outcome.
Keratinocytes and neutrophils are important sources of proinflammatory molecules in hidradenitis suppurativa
Authors: A.L. Lima, I. Karl, T. Giner, H. Poppe, M. Schmidt, D. Presser, M. Goebeler, B. Bauer
Journal: British Journal of Dermatology (2015)

The pathogenesis of the chronic inflammatory skin disease hidradenitis suppurativa (HS, also known as acne inversa) involves epidermal alterations such as psoriasiform epidermal hyperplasia and keratin plugging. Keratinocytes are an important source of proinflammatory molecules in inflammatory skin diseases and can be stimulated by interleukin (IL)-17(+) cells.To explore the possible role of the epithelium in the pathogenesis of HS.We performed immunohistochemical stainings and Western blot experiments to investigate the localization and expression of inflammation-associated molecules, including the cytokine IL-17, components of the inflammasome including caspase-1, and the endogenous danger-associated molecular pattern molecules S100A8 and S100A9 (calprotectin). To examine a possible effect of upregulated proinflammatory cytokines on the inflammatory infiltrate, differences in the cellular composition of perifollicular and deep dermal infiltrates were analysed.The number of IL-17(+) cells is increased in lesional and perilesional HS skin. The epidermis produces proinflammatory molecules and shows an upregulated expression of components of the NLRP3 inflammasome, activated caspase-1 and expression of S100A8/S100A9. Additionally, the course of the inflammatory process in HS involves influx of innate immune cells, particularly IL-17-expressing neutrophils.IL-17-producing cells are present in lesional and perilesional HS skin and may contribute to the initiation of inflammatory processes. Furthermore, the epidermis is a source of proinflammatory cytokines, shows inflammasome activation and expresses S100A8/S100A9, thereby possibly contributing to the propagation of inflammation. A massive influx of IL-17-expressing neutrophils is observed in the deep infiltrate.
The gastrointestinal stimulus to insulin release
Authors: E. W. Kraegen, D. J. Chisholm, J. D. Young, L. Lazarus
Journal: Journal of Clinical Investigation (1970)

The insulin release after an oral glucose load is both earlier and greater than would be expected from the glycemic stimulus. This augmentation of insulin release has been attributed to humoral factors from the gut. It has been previously demonstrated that secretin is released very rapidly after oral glucose and postulated that it acts as an early trigger to insulin release. This effect would not explain the magnitude of the peak insulin response which occurs about 30 min after peak secretin levels. The present studies, however, demonstrate an additional action of secretin which may explain this. To further study the role of secretin in insulin release in normal subjects, two consecutive 20 min intravenous glucose infusions were administered 150 min apart with and without an intervening secretin infusion (10 U) given to approximate serum secretin levels seen after oral glucose ingestion. A highly significant (P<0.01) potentiation of the insulin response to the post-secretin glucose infusion was observed. This occurred both when secretin was given 7 min or 25 min before glucose. In the latter case, serum secretin was undetectable during the glucose infusion. These studies demonstrate that secretin potentiates the glycemic release of insulin. Despite the augmented insulin response, no consistent change in blood glucose variation was observed. This is consistent with the suggestion that the facilitated disposal of an alimentary glucose load is not dependent solely on enhanced insulin secretion. Secretin appears to have a dual role in insulin release, an early direct stimulation followed by a prolonged potentiation of the glycemic stimulus. The potentiating effect is of such magnitude to suggest that secretin is the dominant factor in the enteric component of insulin release after an oral glucose load.
Restrictive pattern of lung function in the general adult population of northern Sweden
Authors: Helena Backman, Caroline Stridsman, Linnea Hedman, Sven-Arne Jansson, Anne Lindberg, Eva Rönmark, Bo Lundback
Journal: European Respiratory Journal (2014)

Background  Restrictive lung function is defined as reduced lung expansion expressed as a decreased total lung capacity. Attempts have been made to use dynamic spirometry to define restrictive patterns of lung function, and studies such as the NHANES and Tucson studies have reported high prevalence of restriction.   Aim  To estimate the prevalence of restrictive spirometric pattern among adults in northern Sweden.   Methods  In 2008-2009 a general population sample aged 22-81y from northern Sweden was examined by structured interview and spirometry, and 726 subjects participated (71% of invited). Restrictive pattern was defined as post bronchodilator 1) FVCl80% of predicted and FEV1/FVCgLLN 5%, 2) FVClLLN 5% and FEV1/FVCgLLN 5%, and 3) FVCl80% of predicted and FEV1/FVCg0.7. The GLI reference equations were used. Demographic and environmental risk factors were calculated by uni-variate and multiple logistic regression analyses.   Results  According to model 1), the prevalence of restrictive spirometric pattern was 2.9%, to model 2) 2.1%, and 3) 2.5%, with no significant gender difference. According to model 1), the prevalence was 4.0% in ages g60y vs. 2.3% in ages ≤60y, p=0.18. By socio-economic status, the prevalence was highest among manual workers in industry, 5.8%, p=0.02 vs. all others. The prevalence among ever smokers was 3.4% vs. 2.4% in never smokers (ns). In risk analyses, no other significant association except the risk of being a manual worker in industry was found.   Conclusions  The prevalence on population level of restrictive spirometric pattern was low, 2-3%. Manual workers in industry were associated with an increased risk, and no other significant risk factors were found.
Severe outcome of influenza A/H1N1/09v infection associated with 222G/N polymorphisms in the haemagglutinin: a multicentre study
Authors: F. Baldanti, G. Campanini, A. Piralla, F. Rovida, A. Braschi, F. Mojoli, G. Iotti, M. Belliato, P.G. Conaldi, A. Arcadipane, E. Pariani, A. Zanetti, L. Minoli, V. Emmi
Journal: Clinical Microbiology and Infection (2010)
Potential source of human exposure to Mycobacterium bovis in Burkina Faso, in the context of the HIV epidemic
Authors: Marc Vekemans, Michel Cartoux, Serge Diagbouga, Mathurin Dembélé, Barthélémy Koné, Arnaud Delafosse, Ardjouma Dera, Philippe Van de Perre
Journal: Clinical Microbiology and Infection (1999)