tbuckley/cabot-search huggingface dataset:
What if … (Between)
Authors: Elisabeth S. Goodridge
Journal: Annals of Internal Medicine (2009)

Ad Libitum6 October 2009What if … (Between)Elisabeth S. GoodridgeElisabeth S. GoodridgeFrom Appleton, ME 04862.Search for more papers by this authorAuthor, Article and Disclosure Informationhttps://doi.org/10.7326/0003-4819-151-7-200910060-00011 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail The starlings make their nestBetweenThe two worlds of house and barn.They invade the weak pointIn the eaves,Filling the air with their chattering,Sweet earthy sounds.By Equinox, they are thereIn this safe place of touch and warm;In the crack betweenRealities.The house with its quiet rituals isPredictable, domestic, hung withWhite curtains,Filled with warm smells ofBaking bread, tousled, unmade featherbeds,Whistling kettles, human music.Visions... Author, Article and Disclosure InformationAffiliations: From Appleton, ME 04862.Current Author Address: Elisabeth S. Goodridge, 2648 Sennebec Road, Appleton, ME 04862. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 6 October 2009Volume 151, Issue 7Page: 508KeywordsIntoxicationVisionTouchSmellBreadHoneyStorms ePublished: 6 October 2009 Issue Published: 6 October 2009 CopyrightCopyright © 2009 by American College of Physicians. All Rights Reserved.Loading ...
Fundholders have saved pounds sterling111m since 1991 BMA will insist on secure NHS network Defence medical services are realistic, government says Commons debates surgeon's case Head injury services are failing in Wales
Authors: L. Beecham
Journal: BMJ (1995)

# Fundholders have saved pounds sterling111m since 1991 {#article-title-2}

By 31 March 1994 general practice fundholders had saved pounds sterling111m but spent only pounds sterling19m, according to a report from the Audit Commission. In its Briefing on GP Fundholding the commission says that of the pounds sterling19m, 35% has been invested in doctor's premises, 25% on furnishings and nonmedical equipment, 15% on medical equipment, and 25% on hospital and community services.

Spending on premises is legitimate, but the commission's controller, Mr Andrew Foster, said, “If there were major patient services not being offered while money went into building, then that would have to raise a question.” Fundholders have four years to spend any budget surpluses, and the past president of the National Association of Fundholding Practices, Dr David Tod, said that fundholders had been advised to retain part of any budget surplus against possible overspends in subsequent years.

The report shows that nearly one in three practices is now fundholding, that 41% of patients in England and Wales are registered with a fundholding practice, and that fundholders manage about 8% of all spending on hospital and community health services; this could rise to 14% from April 1996. The population covered by fundholders varies across Britain from 4% in Camden and Islington Family Health Services Authority in London to 84% in Derbyshire and the Isle of Wight. The average fundholder has a budget of pounds sterling1.7m, and most fundholders have between pounds sterling140 and pounds sterling170 per patient.

The commission surveyed more than two thirds of all fundholders for its interim report and will now …
Isolated Tricuspid Stenosis
Authors: JACOB R. MORGAN, ALAN D. FORKER, J. R. COATES, W. S. MYERS
Journal: Circulation (1971)

A case is reported of isolated tricuspid stenosis with a 5-year hemodynamic follow-up after a tricuspid commissurotomy. Fusion of the commissures and chordae tendineae of the tricuspid valve was noted at surgery. There was a history of rheumatic fever, and 5 years after surgery mild mitral stenosis had developed. Seven previously reported cases of isolated tricuspid stenosis have been considered by some authors to be congenital in origin, and, therefore, isolated tricuspid stenosis of rheumatic origin is thought to be established for the first time.
Surgeon jailed for manslaughter after postponing surgery on man with perforated bowel
Authors: C. Dyer
Journal: BMJ (2013)

A senior surgeon at a private hospital has been jailed for two-and-a-half years for causing the death of a patient through gross negligence.

David Sellu, 66, was convicted of manslaughter over the death of retired builder James Hughes at the Clementine Churchill Hospital in Harrow, north London.

The case is unusual because doctors are rarely convicted of manslaughter in the United Kingdom and for a doctor to be jailed for killing a patient …
Model of Complications of NIDDM: II. Analysis of the health benefits and cost-effectiveness of treating NIDDM with the goal of normoglycemia
Authors: Richard C Eastman, Jonathan C Javitt, William H Herman, Erik J Dasbach, Catherine Copley-Merriman, William Maier, Fred Dong, Diane Manninen, Arthur S Zbrozek, James Kotsanos, Sanford A Garfield, Maureen Harris
Journal: Diabetes Care (1997)

To analyze the health benefits and economics of treating NIDDM with the goal of normoglycemia.Incidence-based simulation model of NIDDM was used. Hazard rates for complications were adjusted for glycemia using risk gradients from the Diabetes Control and Complications Trial. Treatment costs were estimated from national survey data and clinical trials. Incremental costs and benefits were expressed in present value dollars (3% discount rate). Life-years were adjusted for quality of life, yielding quality-adjusted life-years (QALYs).Comprehensive treatment of NIDDM that maintains an HbA1c value of 7.2% is predicted to reduce the cumulative incidence of blindness, end-stage renal disease, and lower-extremity amputation by 72, 87, and 67%, respectively. Cardiovascular disease risk increased by 3% (no effect of treating glycemia is assumed). Life expectancy increased 1.39 years. The cost of treating hyperglycemia increased by almost twofold, which is partially offset by reductions in the cost of complications. The estimated incremental cost/QALY gained is $16,002. Treatment is more cost-effective for those with longer glycemic exposure (earlier onset of diabetes), minorities, and those with higher HbA1c under standard care.The incremental effectiveness of treating NIDDM with the goal of normoglycemia is estimated to be approximately $16,000/QALY gained, which is in the range of interventions that are generally considered cost-effective.
Bronchial disease in ulcerative colitis.
Authors: T Higenbottam, G M Cochrane, T J Clark, D Turner, R Millis, W Seymour
Journal: Thorax (1980)

Ten patients with ulcerative colitis, all of whom were non-smokers, presented with a productive cough. In six, the chest radiography was normal and cough was the only symptom; three of these patients had a minor obstructive ventilatory defect on testing. Four patients complained of exertional dyspnoea and had both an abnormal chest radiograph with bilateral pulmonary shadows and a mixed obstructive and restrictive ventilatory defect. Bronchial epithelial biopsies from four patients (two with and two without pulmonary shadows) revealed basal reserve cell hyperplasia, basement membrane thickening, and submucosal inflammation, changes more usually associated with cigarette smoking. Inhaled beclomethasone diproprionate relieved cough in seven patients. The occurrence of airway epithelial disease in association with ulcerative colitis raises the possibility of a systemic mechanism affecting both bronchial and colonic epithelium. It does not seem likely that sulphasalazine was the cause of the pulmonary syndrome in these subjects.
Abstract 2128: Salvianolic acid B inhibits both ER-α +/- breast cancer cell growth <i>in vivo</i> and <i>in vitro</i>
Authors: Wei Sha, Xinbin Gu, Yinhan Guo, Paul Wang, Saraswati Sukumar, Yanfei Zhou
Journal: Cancer Research (2011)

Abstract PURPOSE: Estrogen receptor α negative (ER-α/-) breast cancer cells are found to respond poorly to chemotherapeutic agents. Salvianolic acid B (Sal-B) is an active depside compound isolated from Salvia miltiorrhiza Bge, which is a well-known Chinese medicine that has been widely used to treat various disorders including cancers. In this study, we evaluated the anti-cancer activity of Sal-B leading to ceramide-mediated apoptosis in ER-α + and ER-α – cancer cell lines. DESIGN METHODS: Using MCF-7-luc (ER-α/+) and MDA-MB-231-luc (ER-α/-) human breast cancer cell lines as a test model, cell-based bioluminescence assay and colony assay for cell viability, Western Blot analysis for ER-α and apoptosis-related proteins expression, flow cytometry analysis for cell cycle, and tumor xenografts were performed. RESULTS: Significant decreased cell viabilities (p&amp;lt;0.05) were observed in Sal-B treated ER-α + and ER-α – cells. The expression of anti-apoptotic proteins (Bcl-2, Bcl-XL and surviving) and ceramide metabolism enzymes (GCS and GM3 synthase) all markedly decreased. Sal-B treatment suppressed cell cycle related protein expression, such as cyclin A and B. Further analysis using flow cytometry confirmed these observations. The tumor size was significantly lower in Sal-B treated MDA-MB-231-luc cells transplanted mice group compared to untreated control group and doxorubicin treated group. CONCLUSION: Sal-B effectively inhibits the growth of cultured ER-α +/- cell lines and MDA-MB-231-luc tumor xenografts. In addition, Sal-B is able to modulate ceramide-mediated apoptosis by inhibiting ceramide metabolic enzymes (GCS and GM3 synthase). Thus, Sal-B has high potential to be a new therapeutic strategy to improve ER-α/- cancer treatment. Research supported in part by grants P20 CA118770 and U54 CA091431 from NCI/NIH and 2G12 RR003048 from the RCMI Program/NCRR/NIH. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 102nd Annual Meeting of the American Association for Cancer Research; 2011 Apr 2-6; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2011;71(8 Suppl):Abstract nr 2128. doi:10.1158/1538-7445.AM2011-2128
Psoas Abscess Demonstrated with SPECT and CT
Authors: WILLIAM H. McCUSKEY
Journal: Clinical Nuclear Medicine (1993)

A Ga-67 SPECT study demonstrated abnormal accumulation of radionuclide in the region of the right psoas muscle in a febrile patient with right hip pain. A CT scan revealed a rim-enhancing fluid density collection confirming an abscess within the right psoas muscle.
Southall's secret case files show no reason to suspect miscarriages of justice
Authors: C. Dyer
Journal: BMJ (2008)

A 17 month review of “secret” case files on children held by the paediatrician David Southall has found no evidence that any information was kept from the defence when prosecutions took place.

The Crown Prosecution Service’s review was set up in February 2007 by the then attorney general, Lord Goldsmith, after it emerged that Dr Southall kept 4344 “special” case files on children that were not stored on their hospital records.

The review team searched the files to try to find those in which he had appeared as a prosecution witness and ensure …
Interaction of Transmembrane Potentials in Canine Purkinje Fibers and at Purkinje Fiber-Muscle Junctions
Authors: CARLOS MENDEZ, WILLIAM J. MUELLER, JOHN MERIDETH, GORDON K. MOE
Journal: Circulation Research (1969)

Interactions between Purkinje fibers and ventricular muscle were studied in canine Purkinje-papillary muscle preparations. The change in duration of action potentials across the junctions between Purkinje fibers and papillary muscle was continuously graded, not abrupt. The transmembrane action potentials were longest in the false tendons and progressively shorter in more peripheral fibers. The responses of terminal Purkinje fibers and of neighboring muscle cells differed little in duration. The shortest action potentials were found in muscle fibers located in regions devoid of specialized tissue (tip of papillary muscle). These results suggest that the intercellular connections, including those at the junctions, offer relatively low resistance to current flow. During repolarization the current flowing between neighboring elements with intrinsically different repolarization times should therefore minimize the disparity in action potential durations on the two sides of the junctional site; a continuously graded change in duration would result. Because of this continuous gradation, premature ventricular responses initiated at the tip of the papillary muscle could be blocked, depending on the degree of prematurity, at various levels in muscle fibers functionally close to terminal Purkinje fibers or within the Purkinje system.
THE TOLL-LIKE RECEPTOR 4 LIGANDS S100A8 AND S100A9 ARE CRUCIAL FACTORS IN VIRAL CARDIOMYOPATHY
Authors: Peter Moritz Becher, Diana Lindner, Kostantinos Savvatis, Irene Müller, Matthias Fröhlich, Thomas Vogl, Johannes Roth, Heinz-Peter Schultheiss, Carsten Tschöpe
Journal: Journal of the American College of Cardiology (2013)
1072. Delivery of Oncolytic Herpes Simplex Virus to Infiltrative Brain Tumor Sites Via Neuronal Stem Cells
Authors: Tyler T. Voss, Kevin R. Bobbitt, Chaya Brodie, Evan Synder, Cathie G. Miller
Journal: Molecular Therapy (2006)

Top of pageAbstract
Primary brain tumors, or Glioblastomas (GBMs), are devastating to each patient diagnosed due to the inability of current therapy to prolong survival. Thus, GBMs are prime candidates for trials of novel therapeutic modalities. One such novel therapy is oncolytic herpes simplex viruses (OHV). Oncolytic viral therapy (OV) has been explored as a potential therapy for many tumor types for many years. However, significant gains in ability to treat GBMs with OVs have not occurred. A significant problem with OV for GBM therapy is the inability of the virus to overcome the migratory infiltrative nature of tumor growth, a unique problem with GBMs. Thus, we determined the ability of neural stem cells (NSCs) to deliver OHV to sites of infiltrative tumor growth following intratumoral delivery of the stem cells. For this end, we utilized an infiltrative, HSV-sensitive GBM tumor model in syngenic, immunocompetent C57/Bl6 mice. We see greater distribution of the virus through the main injected tumor mass following NSC delivery than compared with that seen following OHV alone delivery. Furthermore, NSCs and virally infected cells are found in distal infiltrative tumor sites following NSC/OHV delivery. Delivery of the OHV via NSCs also leads to an alteration in the activation of the immune response to both viral and tumor antigens. Thus, delivery of infectious virus through the use of neural stem cells may be a feasible way to gain greater distribution of therapeutic agents such as OHV.
Book: Slide Atlas of Diabetes: Lecture Notes
Authors: W. Jeffcoate
Journal: BMJ (2000)

John C Pickup, Gareth Williams Blackwell Science, £150, pp 12 ISBN 0 632 05014 4 Rating: ![Graphic][1]</img>![Graphic][2]</img> This is not a book but a set of slides, making the reviewer's job a difficult one. The subheading “Lecture Notes” is misleading—the only text is a few pages of legends, which are often skimpy and vague. Some of these are also rather inappropriate: for example, one slide is called “The responsibilities of the diabetes specialist nurse.” Is “responsibilities” really the right word to summarise the many tasks … [1]: /embed/inline-graphic-1.gif [2]: /embed/inline-graphic-2.gif
Transferring medical images on the world wide web for emergency clinical management: a case report
Authors: D. S Johnson, R. P Goel, P. Birtwistle, P. Hirst
Journal: BMJ (1998)

Although the ability to transmit radiographs over the telephone has been feasible since 1929,1 more advanced systems have been slow in introduction. We describe a simple system for transmitting medical images across a system based on personal computers and the internet's world wide web.

A system for transfer of medical images was set up in our orthopaedic department (fig 1). Clinical photographs were taken with an Apple Quicktake 150 digital camera, and radiographs were scanned on an Epson GT9000 flat bed scanner. The resulting digital images were converted to Joint Photographic Experts Group (JPEG) format at maximum quality using Adobe Photoshop on an Apple Power Macintosh computer. The files were saved onto a password protected area of the departmental website, which is maintained …
Weighing the Risks and Benefits of Bariatric Surgery
Authors: Oliver A. Varban, Justin B. Dimick
Journal: JAMA Surgery (2015)

Bariatric surgery offers patients an explicit choice, a tradeoff between risks and benefits. Making the right choice is a complex balance between the risks of surgery (eg, short-term and long-term complications) and the benefits of weight loss (eg, resolution of comorbid diseases and increased longevity). When compared with other bariatric procedures, biliopancreatic diversion with duodenal switch offers maximal weight loss, yet it continues to be the least common operation performed.1 The Risstad et al2 study reminds us why. We learnedfromRisstadetal2 that 1ormoreadverseevents occurred in nearly 80% of patients during the first 5 years after duodenal switch. This included a 14%hospitalization rate for protein and vitamin malabsorption as well as a reoperation rate of 45% to address problems of the initial procedure. The high rate of adverse events with duodenal switch is consistent with other reports.3 Moreover, the benefits of undergoing duodenal switch hardly seemworth the sacrifice when comparedwith gastric bypass. In this study, duodenal switch resulted in significantlymoreweight loss and lower serumlevels of lipids but therewere no significant differences in blood pressure, type 2 diabetes mellitus, metabolic syndrome, and pulmonary function. Given the high complication rates of duodenal switch in the study by Risstad et al, it is difficult to recommend duodenal switchasa first-lineweight lossprocedure.At thevery least, patients seeking this procedure should receive ample warning regarding the very high risks of adverse nutritional outcomes and the high reoperation rate. Patientswith poor complianceandpoor follow-upshouldnotbeofferedthisprocedure because they could be at risk of fatal complications if postoperative problems are not addressed in a timely fashion. Despite itsnarrowrole inclinicalpractice,duodenal switch may find a resurgence in the future as a second stage procedure for patients who have failed weight loss after sleeve gastrectomy.4 Sleeve gastrectomy, which is part of the duodenal switchoperation, isnowthemost commonbariatricprocedure performed in many regions of the country. Many surgeons advocate revising patientswith inadequateweight loss after sleeve gastrectomy to aduodenal switch.Risstad et al remindus that this strategy should only beusedwith great caution and only in a select group of patients with excellent follow-up and compliance.
An Adjourned Section Meeting.
Authors: C. S. N. Hallberg
Journal: JAMA (1904)

Chicago, June 27, 1904. <h3>To the Editor:</h3> —Dr. Shoemaker's criticism concerning the premature adjournment of the section is in a sense justified. It was the intention of the officers not to permit the very thing which did happen. A number of members whose names were on the program were present at the session, but failed to appear at the meetings, three because as delegates their, presence was required in the House. Three of the authors who appeared on the Friday morning program were anxious to leave earlier and they were substituted for the absentees. This left only one paper for Friday, that referred to by Dr. Shoemaker, and there was doubt as to Dr. McDonnell's attendance. There was consequently nothing to do but to prematurely adjourn. It is regretted fully as much by the chairman, Dr. Osborne, and the secretary as by anyone, and especial apology is due to Dr.
1169-153 Intra-aortic balloon counterpulsation improves regional systolic function after acute myocardial infarction: Randomized experimental magnetic resonance imaging study
Authors: Clerio F Azevedo, Luciano C Amado, Dara L Kraitchman, Bernhard L Gerber, Nael F Osman, Carlos E Rochitte, Katherine C Wu, Joao A Lima
Journal: Journal of the American College of Cardiology (2004)
Failure of conservative management post-thrombolysis: Profile of the TAMI-5 crossover population
Authors: D.W.M. Muller, E.J. Topol, Lynn Harrelson, S.G. Ellis, B.S. George, D.J. Kereiakes, J Samaha, S Worley, R.M. Califf
Journal: Journal of the American College of Cardiology (1990)
Tissue Plasminogen Activator and Intracranial Hemorrhage
Authors: Richard C. Becker
Journal: Annals of Internal Medicine (1990)

Letters and Corrections15 April 1990Tissue Plasminogen Activator and Intracranial HemorrhageRichard C. Becker, MD, Joel M. Gore, MDRichard C. Becker, MDSearch for more papers by this author, Joel M. Gore, MDSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-112-8-630_1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the Editor:We read with interest and concern the recent article by Kase and colleagues (1). During the past several years, plasminogen activators, including recombinant tissue-type plasminogen activator (rt-PA), have revolutionized the treatment of acute myocardial infarction (2, 3). However, because plasmin degrades circulating fibrinogen, factor V, and factor VIII and modifies platelet activity, and because thrombolytic agents are combined frequently with systemic anticoagulants and platelet inhibitors, the risk for hemorrhagic complications, including intracranial hemorrhage, exists. Since June 1984, we have treated over 350 patients with rt-PA and have observed an intracranial hemorrhage rate of less than 1%. In...References1. KaseO'NealFisherGirgisOrdia CAMGJ. Intracranial hemorrhage after use of tissue plasminogen activator for coronary thrombolysis. Ann Intern Med. 1990;112:17-21. LinkGoogle Scholar2. . Effect of intravenous APSAC on mortality after acute myocardial infarction: preliminary report of a placebo-controlled clinical trial. Lancet. 1988;1:545-9. MedlineGoogle Scholar3. . Randomized trial of intravenous streptokinase, oral aspirin, both, or neither among 17,187 cases of suspected acute myocardial infarction. Lancet. 1988;2:349-60. MedlineGoogle Scholar4. GoreSloanPrice JMT. Intracranial hemorrhage after rt-PA and heparin for acute myocardial infarction—the TIMI II pilot and randomized trial combined experience. J Am Coll Cardiol. 1990;[In press]. CrossrefGoogle Scholar5. ChaitmanThompsonWittry BBM. The use of tissue plasminogen activator for acute myocardial infarction for the elderly: results from Thrombolysis in Myocardial Infarction Phase I, open label studies and the Thrombolysis in Myocardial Infarction Phase II pilot study. J Am Coll Cardiol. 1989;14:1159-65. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Thrombosis Research Center University of Massachusetts Medical School Worcester, MA 01655 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byXenon/Computed Tomography Cerebral Blood Flow and its use in Clinical ManagementIntegrating occupational health into the medicine clerkship using problem-based learning 15 April 1990Volume 112, Issue 8Page: 630-630KeywordsAcute myocardial infarctionAnticoagulantsFibrinogenHemorrhagePlasminsPlateletsTissue plasminogen activator Issue Published: 15 April 1990 PDF downloadLoading ...
Absence of statistically significant correlation between disparity for the minor histocompatibility antigen HA-1 and outcome after allogeneic hematopoietic cell transplantation
Authors: Ming-Tseh Lin, Ted Gooley, John A. Hansen, Li-Hui Tseng, Emily G. Martin, Kentner Singleton, Anajane G. Smith, Eric Mickelson, Effie W. Petersdorf, Paul J. Martin
Journal: Blood (2001)
Aberrant topoisomerase-1 DNA lesions are pathogenic in neurodegenerative genome instability syndromes
Authors: Sachin Katyal, Youngsoo Lee, Karin C Nitiss, Susanna M Downing, Yang Li, Mikio Shimada, Jingfeng Zhao, Helen R Russell, John H J Petrini, John L Nitiss, Peter J McKinnon
Journal: Nature Neuroscience (2014)