tbuckley/cabot-search huggingface dataset:
Early Electrocardiographic Changes of Left Heart Strain in Congenital Aortic Stenosis
Authors: R. S. SHAH, J. T. FISHER
Journal: Circulation (1962)

INCE THE ADVENT ol surgery 1ou1 aortie stenosis, the recognition of the earliest manifestationis of left heart strain has become extremely inmportant, especially in view of the seriousiess of the lesion-and becauise of the possib)ility of suddein death.1The ineidenee of sudden death as reported by various authors ranges from 4 to 18 per cent.2-,It is a well-recognized fact that defeetive filling of the coronary arteries and resultant myoeardial hypoxia may be ex- tremely important in the cardiac symptoms eansed by aortic stenosis.Goldberger7 has reported that abinormal S-T elevations an(i disappearance of the normally inverted T waves ini lead aVR is a sigT of myii-ocardial anioxia due to coronary insufficiency.This ob- scrvation led us, to wonider whethier, in addi- tioii to the well-recognized signs of left hearti ''strain,'' other changes might be present.For this reason a study of the electrocardio- graphic changc,es was undertaken and special attention was paid to lead aV11 and Vl. MaterialThis studv is concerned with the electrocardiog-raphie changes in 30 caises of congenital aortic stenosis, proved at operaition or at autopsy.The agre of the patients ranged fromii 51/2?miionths to 24 years.All patients on digitalis were excluded.In 20 patients left heart eatheterization wtas done.Figure 1 shows an eleetrocardiogram of one of our patiients (patient 26 in table 1).It will he seen that in addition to the well-recognized changes of left heart "strain" in leads V-and V( S-T elevations are present in leads aV11 and V1.The changes in the various leads of the electro- cardiogranms were tabulated.T':ilbles 1 and 2 list the electrocardiographic changes of all the patients, slhowing-the S-T segment aind T-wave changes in leads aVg, V1, and leads V5 and From the Cardiac Clinic, IHarriet Lanme Home,
The Art of Aging: A Doctor’s Prescription for Well-Being
Authors: Preeti N. Malani
Journal: JAMA (2007)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The Treatment of Graves Disease
Authors: Robert H. Caplan
Journal: JAMA (1974)

To the Editor.—  In their letter (227:939, 1974) on treatment of Graves disease, Caswell and Maier unfortunately overemphasize the deficiencies of radioactive iodine and antithyroid drug therapy and do not adequately discuss the disadvantages of subtotal thyroidectomy. The authors state that patients treated with radioactive iodine frequently require multiple doses, resulting in prolongation of a serious illness. This is not the case, because 80% of patients are rendered euthyroid with one dose of radioactive iodine. 1 In addition, antithyroid drugs, iodide, or propranolol— the same medications used to render a patient euthyroid before surgery— may be used prior to or soon after the administration of radioactive iodine in seriously ill patients to achieve euthyroidism as quickly as possible. The authors also imply that radioactive iodine is particularly disadvantageous to women in the childbearing years. Although radioactive iodine is contraindicated during pregnancy, genetic damage to progeny in women previously treated with
Expression level and differential JAK2-V617F–binding of the adaptor protein Lnk regulates JAK2-mediated signals in myeloproliferative neoplasms
Authors: Fanny Baran-Marszak, Hajer Magdoud, Christophe Desterke, Anabell Alvarado, Claudine Roger, Stéphanie Harel, Elizabeth Mazoyer, Bruno Cassinat, Sylvie Chevret, Carole Tonetti, Stéphane Giraudier, Pierre Fenaux, Florence Cymbalista, Nadine Varin-Blank, Marie-Caroline Le Bousse-Kerdilès, Jean-Jacques Kiladjian, Laura Velazquez
Journal: Blood (2010)
Leptin controls adipose tissue lipogenesis via central, STAT3–independent mechanisms
Authors: Christoph Buettner, Evan D Muse, Andrew Cheng, Linghong Chen, Thomas Scherer, Alessandro Pocai, Kai Su, Bob Cheng, Xiasong Li, Judith Harvey-White, Gary J Schwartz, George Kunos, Luciano Rossetti
Journal: Nature Medicine (2008)
Epidemic of glandular fever.
Authors: M. Klaber, J. Lacey
Journal: BMJ (1968)

HJouRNA the most reliable and best technique is to determine the presence of C.P.P.D. by x-ray diffraction.This method can be used even when only microscopic specimens of the material are available.Calcification of the meniscus in the knee is very common in chondrocalcinosis.In the roentgenological examination of such cases various projections should be tried in order to visualize also calcifications of the joint cartilage, which are of greater significance in the diagnosis of chondrocalcinosis.The synovial fluid (joint effusion) has been described as milky and was of such appear- ance in one of our cases at Ljungby.In their series of 33 cases D. Zitfian and S. SitAj' found five pedigrees with 24 cases,
Sodium and Water Excretion Abnormalities in Congestive Heart Failure
Authors: BERTRAND METTAUER
Journal: Annals of Internal Medicine (1986)

The renal hemodynamic and neurohumoral determinants of sodium and water excretion abnormalities were studied in 66 patients with severe chronic congestive heart failure. Abnormalities were not closely related to any one variable but were the result of the convergence of a number of determinants. The most important determinants for sodium excretion were activation of the renin-angiotensin system and ventricular function; and the most important for water excretion were plasma vasopressin, plasma norepinephrine, and renal and ventricular functions. In a subgroup of patients, neurohumoral overactivation led to severe sodium and water excretion abnormalities and to increased furosemide requirements. A 17-month follow-up of all 66 patients showed a less favorable clinical course for this subgroup even when compared with hemodynamically matched patients.
713. Growth Suppression of Hepatocellular Carcinoma by AAV-Mediated Angiogenic Inhibitors
Authors: Lai-Yin Tse, Ruian Xu
Journal: Molecular Therapy (2005)

Hepatocellular carcinoma (HCC) is one of the most common tumors worldwide with about one million new cases diagnosed annually. It is estimated that the incidence of hepatocellular carcinoma in the seven major pharma markets will continue to rise over the next decade. Surgical resection or liver transplantation is the treatment of choice for HCC, but most patients are not suitable candidates. Current pharmacotherapies are largely ineffective for hepatocellular carcinoma and medical oncologists face the challenge of gaining benefit from relatively ineffective drugs currently available for hepatocellular carcinoma. In addition to the problems surrounding the limited capacity of the liver to deal with cytotoxics, hepatocellular carcinoma is a highly resistant tumor, thought to be because it is a malignancy of cells that confer protection to other cells from toxins. This protective role is thought to give hepatocytes additional mechanisms of resistance to various anticancer drugs.
Resistance to Erythropoietin
Authors: Catherine Lacombe
Journal: New England Journal of Medicine (1996)

The main function of red cells is to transport oxygen from the lungs to the peripheral tissues. Erythropoietin controls red-cell production by stimulating the differentiation of erythroid progenitor cells in the bone marrow. The hormone originates mainly in specialized interstitial renal cells, which respond to a decrease in oxygen delivery by increasing their production of erythropoietin. The purification of erythropoietin from the urine of patients with aplastic anemia by Miyake et al.1 permitted cloning of the erythropoietin gene in 1985. The commercial production of recombinant erythropoietin soon followed, opening the way to the first clinical trials of a hematopoietic growth . . .
Chronic gastritis and gastric ulcer
Authors: I. R. Mackay, I. G. Hislop
Journal: Gut (1966)

The authors focus attention on the possible role of chronic gastritis as a cause of gastric ulceration and bleeding resulting from decreased mucosal resistance.Duodenal and gastric antral ulcers differ in certain respects from ulcers in the body of the stomach.Thus with duodenal and gastric antral ulcers there is a high gastric acidity, a large parietal cell mass, and a histologically normal gastric mucosa (Cox, 1952; Ball, 1961), whereas with gastric ulcers there is a normal, low, or even greatly reduced, gastric acid secretion (Levin, Kirsner, Palmer, and Butler, 1948; Morlock and Ratke, 1949; Ball, 1961; Baron, 1963), a reduced parietal cell mass, and often a histologically abnormal gastric mucosa with changes of gastritis (Magnus, 1952; Ball and James, 1961).Hence 'decreased mucosal resistance' rather than hyperacidity is claimed to be the important factor in the pathogenesis of gastric ulcer (Illingworth, 1956; Marks and Shay, 1959).This paper describes nine patients in whom gastric ulceration and/or bleeding occurred as a complication of active chronic gastritis: the concept is presented that pre-existing chronic gastritis, in representing one cause of decreased mucosal resistance, is of importance in the pathogenesis of gastric ulceration.METHODS Gastric acid production was assessed by intermittent aspiration of the stomach after an injection of 0 3 mg.('standard' test) or 0-6 mg. ('high dosage' test) of hista- mine (Kay, 1953): the term 'histamine test' denotes the standard test unless otherwise stated.The gastric aspirate was titrated to apH of 3-5, using Topfer's reagent, and the output of acid was expressed as milliequivalents over a 90- minute period.3The methods for serum vitamin B12 assay and the vitamin B12 absorption and excretion (Schilling) test were as described by Wood, Ralston, Ungar, and Cowling (1964).Serological analyses, including the test for complement-fixing autoantibodies to stomach anti- 'Working with the aid of a grant from the National Health and Medical Research Council of Australia.2Drug Houses of Australia research fellow.'The 90-minute gastric acid production was not measured in test meals before 1956: in these, 'hypochlorhydria' means an acid con- centration below 10 mEq. per litre in serial specimens of gastric juice.
Transfusion-related acute lung injury: incidence and risk factors
Authors: Pearl Toy, Ognjen Gajic, Peter Bacchetti, Mark R. Looney, Michael A. Gropper, Rolf Hubmayr, Clifford A. Lowell, Philip J. Norris, Edward L. Murphy, Richard B. Weiskopf, Gregory Wilson, Monique Koenigsberg, Deanna Lee, Randy Schuller, Ping Wu, Barbara Grimes, Manish J. Gandhi, Jeffrey L. Winters, David Mair, Nora Hirschler, Rosa Sanchez Rosen, Michael A. Matthay
Journal: Blood (2011)
QUANTITATIVE ANALYSIS OF THE MITRAL ANNULUS GEOMETRY AND FUNCTION IN HEALTHY VOLUNTEERS: A TRANSTHORACIC THREE-DIMENSIONAL ECHOCARDIOGRAPHY STUDY
Authors: Sorina Mihaila, Denisa Muraru, Marcelo Miglioranza, Diletta Peluso, Piasentini Eleonora, Sabino Iliceto, Dragos Vinereanu, Luigi Badano
Journal: Journal of the American College of Cardiology (2014)
Continuing Medical Education
Authors: Phil R. Manning
Journal: JAMA (1983)

Traditional continuing medical education (CME) keeps physicians aware of the state of the art. It has limitations, however, as a quality-assurance tool: it is memory based, involves a group endeavor with diffuse goals, often unrelated to practice, is an inappropriate remedy for many problems in patient care, is hampered by poor-quality evaluation, and is governed more by market factors than educational outcomes. The self-study of practice and practice-linked CME offer rich potential for development. The physician's monitoring of his work, with appropriate improvements in performance, is valuable CME. Computers provide facts and guidance at the time and place the physician is developing diagnostic plans, diminishing reliance on memory. The next step in CME is for hospitals, societies, and medical schools to perfect methods of self-study of practice and practice-linked CME.
Amino Acid Starvation Induced by Invasive Bacterial Pathogens Triggers an Innate Host Defense Program
Authors: Ivan Tattoli, Matthew T. Sorbara, Dajana Vuckovic, Arthur Ling, Fraser Soares, Leticia A.M. Carneiro, Chloe Yang, Andrew Emili, Dana J. Philpott, Stephen E. Girardin
Journal: Cell Host & Microbe (2012)
Creating an NIH Clinical Trials Registry: A User-friendly Approach to Health Care
Authors: William R. Harlan
Journal: JAMA (1994)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Case 51-1964
Authors: David G. Freiman, C. Miller Fisher
Journal: New England Journal of Medicine (1964)

Presentation of Case First admission. A forty-four-year-old woman entered the hospital because of difficulty with speech.Three weeks earlier she awoke with slurred speech that persisted for several minutes. She was well thereafter until five days before admission, when slurring of the speech recurred and persisted, and the right hand became unsteady. During the next four days she used inappropriate names for common objects and attempted to use a hair curler as a lipstick.There was no history of headache, head injury, seizure or disturbance of gait. She smoked 2 packages of cigarettes daily. The menses were normal.Physical examination . . .
17q21 Variants and Asthma — Questions and Answers
Authors: John W. Holloway, Gerard H. Koppelman
Journal: New England Journal of Medicine (2008)

It has long been established that many common diseases are the result of interactions between genetic susceptibility and environmental exposure. The identification of genetic variants that underlie susceptibility to diseases and alter the expression or function of proteins (either familiar or novel) can implicate the protein in question in the pathogenesis of the disease. This not only increases the understanding of disease pathophysiology but also can lead to the development of new therapeutic agents. It is this hope that has spurred the search for genetic variants underlying common diseases during the past quarter century.The advances of the Human Genome . . .
Immunoglobulin G-induced single ionic channels in human alveolar macrophage membranes.
Authors: D J Nelson, E R Jacobs, J M Tang, J M Zeller, R C Bone
Journal: Journal of Clinical Investigation (1985)

While it is well known that the engagement of IgG Fc receptors on the macrophage surface triggers a number of cellular responses, including particle ingestion, secretion, and respiratory burst activity, the mechanism of signal transmission following ligand binding remains poorly understood. To acquire more data in this area, we studied the electrical properties of the macrophage membrane and its response to oligomeric immunoglobulin G (IgG) using the patch-clamp technique on human alveolar macrophages that were obtained by bronchoalveolar lavage and maintained in short-term tissue culture. The results showed that cell resting potentials, as determined from whole-cell tight seal recordings, increased from -15 mV on the day of plating to -56 mV after the first day in culture and remained stable at this hyperpolarized level. Macrophages revealed an input resistance of 3.3 G omega, independent of age in culture. Extracellular application of heat-aggregated human IgG to cells voltage-clamped at -70 mV resulted in peak inward currents of approximately 470 pA. We identified an IgG-dependent, nonselective channel in both cell-attached and isolated membrane patches, with a unitary conductance of approximately 350 pS and a predominant subconductance level of 235 pS in symmetrical NaCl solutions. Single channel open times were observed to be in the range of seconds and, in addition, were dependent upon membrane voltage. Channel opening involved transitions between a number of kinetic states and subconductance levels. Channel events recorded in cell-attached patches showed characteristic exponential relaxations, which implied a variation in membrane potential as a result of a single ion channel opening. These data suggest that the IgG-dependent nonselective cation channel that we have characterized may provide the link between Fc receptor engagement and subsequent cellular activation.
Parathyroid Hormone Secretion and Action: Evidence for Discrete Receptors for the Carboxyl-Terminal Region and Related Biological Actions of Carboxyl-Terminal Ligands
Authors: Timothy M. Murray, Leticia G. Rao, Paola Divieti, F. Richard Bringhurst
Journal: Endocrine Reviews (2004)

PTH is a major systemic regulator of the concentrations of calcium, phosphate, and active vitamin D metabolites in blood and of cellular activity in bone. Intermittently administered PTH and amino-terminal PTH peptide fragments or analogs also augment bone mass and currently are being introduced into clinical practice as therapies for osteoporosis. The amino-terminal region of PTH is known to be both necessary and sufficient for full activity at PTH/PTHrP receptors (PTH1Rs), which mediate the classical biological actions of the hormone. It is well known that multiple carboxyl-terminal fragments of PTH are present in blood, where they comprise the major form(s) of circulating hormone, but these fragments have long been regarded as inert by-products of PTH metabolism because they neither bind to nor activate PTH1Rs. New in vitro and in vivo evidence, together with older observations extending over the past 20 yr, now points strongly to the existence of novel large carboxyl-terminal PTH fragments in blood and to receptors for these fragments that appear to mediate unique biological actions in bone. This review traces the development of this field in the context of the evolution of our understanding of the "classical" receptor for amino-terminal PTH and the now convincing evidence for these receptors for carboxyl-terminal PTH. The review summarizes current knowledge of the structure, secretion, and metabolism of PTH and its circulating fragments, details available information concerning the pharmacology and actions of carboxyl-terminal PTH receptors, and frames their likely biological and clinical significance. It seems likely that physiological parathyroid regulation of calcium and bone metabolism may involve receptors for circulating carboxy-terminal PTH ligands as well as the action of amino-terminal determinants within the PTH molecule on the classical PTH1R.
Factor XII stimulates ERK1/2 and Akt through uPAR, integrins, and the EGFR to initiate angiogenesis
Authors: Gretchen A. LaRusch, Fakhri Mahdi, Zia Shariat-Madar, Gregory Adams, Robert G. Sitrin, Wan Ming Zhang, Keith R. McCrae, Alvin H. Schmaier
Journal: Blood (2010)
86 EFFECTS OF PROPHYLACTIC ANTIBIOTICS ON TOLL-LIKE RECEPTOR (TLR) 2 AND 4 EXPRESSION ON PERIPHERAL BLOOD MONONUCLEAR CELLS (PBMC) IN PATIENTS WITH DECOMPENSATED CIRRHOSIS
Authors: A.G. Testro, K. Visvanathan, N.A. Skinner, V. Markovska, S. Wongseelashote, P.W. Angus, P.J. Gow
Journal: Journal of Hepatology (2008)
Animals and Accidents
Authors: Hugh A. Carithers
Journal: New England Journal of Medicine (1963)

IN the culture of today it is difficult for anyone to avoid contact with household pets. Intelligent estimates indicate that there are about 30,000,000 dogs, 35,000,000 cats and 20,000,000 caged birds in this country.1 These animals are increasing by over 1,000,000 yearly, and 2-dog families may soon become as common as 2-car families.Largely because of maltreatment and indiscreet handling animals are biting human beings, particularly children, with increasing frequency.2 When a youngster has forcibly fallen or lunged toward a dog's mouth, wounds may be caused by teeth without biting. Paw and particularly claw scratches are common, and usually these, . . .
Intestinal pseudo-obstruction in patients with amyloidosis: clinicopathologic differences between chemical types of amyloid protein.
Authors: S Tada, M Iida, T Yao, T Kitamoto, T Yao, M Fujishima
Journal: Gut (1993)

A clinicopathologic study was made of 16 patients with amyloidosis and with clinical signs of intestinal pseudo-obstruction. amyloid deposits in the small intestine were proved in all cases by endoscopic or intra-operative biopsies, and immunohistochemical study identified the chemical types of amyloid protein: amyloid A protein (AA) in 13 cases, light chain protein (AL) in two, and beta 2-microglobulin (AH) in one. Clinically, an acute self limiting obstructive condition was evident in 13 cases with AA, and 12 of them returned to normal bowel function after receiving total parenteral nutrition. Two cases with AL and one with AH presented chronic, intermittent, obstructive symptoms, and medical treatment, including total parenteral nutrition, was ineffective with no recovery of intestinal propulsion. Pathological examination of the necropsy specimens in seven cases showed considerable differences in the preferential sites of gastrointestinal deposits between the chemical types of amyloid; extensive infiltration and replacement of the muscularis propria by amyloid deposits throughout the gastrointestinal tract, especially the small intestine, were found in the AL and the AH cases, while amyloid deposits in the myenteric plexus without appreciable muscle infiltration were shown in the AA cases. These results show that intestinal pseudo-obstruction in patients with amyloidosis is caused by either myopathy or neuropathy, and that chemical types of amyloid may determine which of the two factors has the dominant affect on the bowel function.