TREATMENT OF BROMISM WITH THE ARTIFICIAL KIDNEY
Authors: J P MERRILL, J M WELLER
Journal: Annals of Internal Medicine (1952)

Case Reports1 July 1952TREATMENT OF BROMISM WITH THE ARTIFICIAL KIDNEYJOHN P. MERRILL, JOHN M. WELLERJOHN P. MERRILLSearch for more papers by this author, JOHN M. WELLERSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-37-1-186 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe high incidence of chronic bromide intoxication has been repeatedly stressed in the literature.1, 2, 3, 4, 5 The presence of bromide in proprietary remedies which may be sold without prescription particularly lends itself to the prevalence of this clinical condition. Bromides in small doses cause sedation; in high doses, or with continued intake exceeding excretion, chronic poisoning may occur, in which mental and neurologic disturbances are the most prominent features. Delirium, hallucinations, confusion and disorientation may be present in severe cases.The metabolism of the bromide ion is much like that of the chloride ion and, in a sense,...Bibliography1. Kern FJ: A study of fifty cases of bromide psychosis, J. Nerv. and Ment. Dis. 88: 163, 1938. CrossrefGoogle Scholar2. Levin M: Bromide psychosis, diagnosis, treatment, and prevention, Ann. Int. Med. 7: 709, 1933. LinkGoogle Scholar3. PreuRomanoBrown PWJWT: Symptomatic psychosis with bromide intoxication, their occurrence in Southern New England, New England J. Med. 214: 56, 1936. CrossrefGoogle Scholar4. WagnerBunbury GADE: Incidence of bromide intoxication among psychotic patients, J. A. M. A. 95: 1725, 1930. CrossrefGoogle Scholar5. HodgesGilmour HHMT: The continuing hazard of bromide intoxication, Am. J. Med. 10: 459, 1951. CrossrefMedlineGoogle Scholar6. HastingsHarkinsLiu ABHNSK: Blood and urine studies following bromide injection, J. Biol. Chem. 94: 681, 1932. CrossrefGoogle Scholar7. 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M. A. 146: 105-106 (May) 1951. CrossrefMedlineGoogle Scholar15. Merrill JP: Present role of the artificial kidney in clinical therapy, Ann. Int. Med. 33: 100 (July) 1950. LinkGoogle Scholar16. Harrison TR: Principles of Internal Medicine, 1950, The Blakiston Co., Philadelphia, p. 755. Google Scholar17. SchalesSchales OSA: Simple and accurate method for the determination of chloride in biological fluids, J. Biol. Chem. 140: 879, 1941. CrossrefGoogle Scholar18. Wuth O: Rational bromide treatment, J. A. M. A. 88: 2013, 1927. CrossrefGoogle Scholar19. Cornbleet T: Bromide intoxication treated with ammonium chloride, J. A. M. A. 146: 1116, 1951. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Boston, Massachusetts*Received for publication November 3, 1951.From the Medical Service, Peter Bent Brigham Hospital, and the Department of Medicine, Harvard Medical School.This work was aided in part by grants from the American Heart Association and from the National Heart Institute, U. S. P. H. S., and in part by a grant from the office of the Surgeon General, U. S. Army. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byDevelopments in extracorporeal therapy for the poisoned patientBromism from Excessive Cola ConsumptionCDialysis of Poisons and DrugsExtracorporeal and Peritoneal Dialysis of DrugsAtemregulation bei Barbituratvergiftung und bei Cor pulmonaleTreatment of Bromide Intoxication with Ethacrynic Acid and Mannitol DiuresisJAMES S. ADAMSON JR., M.D., WILLIAM J. FLANIGAN, M.D., GEORGE L. 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