tbuckley/cabot-search huggingface dataset:
Coronary Plaque Composition and Post-PCI Complications in NSTEMI
Authors: Cansu Akdeniz, Sabahattin Umman, Abdullah Kaplan, Yilmaz Nisanci, Berrin Umman, Zehra Buğra, Emre Aslanger, Derek J. Hausenloy, Akar Yilmaz, Nihat Polat, Murat Sezer
Journal: JACC. Cardiovascular imaging (2013)
An excitatory nociceptive cardiac reflex elicited by bradykinin and potentiated by prostaglandins and myocardial ischaemia
Authors: J. STASZEWSKA-BARCZAK, S. H. FERREIRA, J. R. VANE
Journal: Cardiovascular Research (1976)

Application of bradykinin to the exposed ventricular surface of the dog heart elicits a reflex cardiovascular response which includes a rise in blood pressure, tachycardia, renal vasoconstriction and muscular vasodilation. The reflex response depends on the dose of bradykinin and is increased by concomitant application of prostaglandin E1 or E2 and reduced by indomethacin. Temporary occlusion of the coronary artery supplying the area of the ventricle under study also sensitized the heart to topical application of bradykinin. Bradykinin and prostaglandins are released by the heart during ischaemia. We suggest, therefore, that bradykinin and prostaglandins acting in concert are the natural stimulus for excitation of the sensory receptors signalling the pain of myocardial ischaemia. We also suggest that the nervous reflex which arises from activation of sympathetic sensory nerve endings is the mechanism subserving the cardiovascular events which accompany anginal attacks.
Short Therapy Reduces Depression in Family Caregivers of Patients With Dementia
Authors: Anita Slomski
Journal: JAMA (2015)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Competition and redistribution among calcium transport systems in rabbit cardiac myocytes
Authors: D. M Bers, J. W M Bassani, R. A Bassani
Journal: Cardiovascular Research (1993)

Normally the sarcoplasmic reticular calcium pump and sarcolemmal Na/Ca exchange compete and are the primary mechanisms responsible for reducing [Ca]i during cardiac relaxation. The sarcolemmal calcium pump and mitochondrial calcium uptake are much slower, but may also participate in [Ca]i regulation. The aim of this study was to provide a clearer understanding of the interaction of these mechanisms. Myocyte shortening and [Ca]i transients (using indo-1 fluorescence) were measured in rabbit ventricular myocytes, with similar results. The t1/2 of twitch relaxation was 0.17(SEM 0.03) s. Contractures induced by 10 mM caffeine (caffeine contraction) relaxed more slowly [t1/2 = 0.54(0.07) s] due to prevention of sarcoplasmic reticular calcium uptake. When the Na/Ca exchange was also blocked by perfusion with 0Na,0Ca solution, the peak of the caffeine contraction was increased (by 44%) and relaxation was slowed about 16-fold [t1/2 = 8.8(0.8) s]. Blocking mitochondrial calcium uptake by including 1 microM FCCP + 1 microM oligomycin in the 0Na,0Ca solution slowed the relaxation of the caffeine contraction further [t1/2 = 19.7(3.2) s]. Inhibition of the sarcolemmal calcium pump by perfusion with 0Na, 10 mM Ca during caffeine contraction also increased the relaxation t1/2 to 27.5(6.9) s. Inhibition of all four calcium transport systems almost abolished relaxation. It is also shown that calcium which was taken up by the mitochondria during relaxation of the caffeine contraction in 0Na,0Ca gradually redistributed (with tau = 41 s) back to the sarcoplasmic reticulum after caffeine was removed. A second caffeine contraction could then be elicited.(ABSTRACT TRUNCATED AT 250 WORDS)
Chronic Lyme disease: it's not all in our heads.
Authors: Robert G Morgenstern
Journal: Environmental Health Perspectives (2003)

Those of us with chronic Lyme disease are not at all confused, as suggested by Sigal and Hassett (2002). We know from years of experience that we have real, specific symptoms that are usually painful and disabling and include severe headaches, crippling arthritis, and heart palpitations, which lead to serious heart disease. Many of us know that our symptoms are kept in check while we are on antibiotics, but they painfully reappear when the antibiotics are withdrawn. Just because the medical community cannot detect a specific causative bacterium and managed health care companies want to maximize profits doesn't mean that those of us afflicted with this terrible condition are delusional and not truly benefiting from antibiotic treatment. We are not all crazy; we are sick and we should not be required to prove it to get medical care.
Dystonic Reaction to Trifluoperazine
Authors: T. S. Davies
Journal: BMJ (1959)

<h3>Abstract</h3> Biodiversity currently peaks at the equator, decreasing toward the poles. Growing fossil evidence suggest that this hump-shaped latitudinal diversity gradient (LDG) has not been persistent through time, with similar species diversity across latitudes flattening out the LDG during past greenhouse periods. This provides a new starting point for LDG research. Most studies assume the processes shaping the LDG have acted constantly through time and seek to understand why diversity accumulated in the Holarctic at lower levels than at the equator, <i>e.g.</i> as the result of limited dispersal, or higher turnover in Holarctic regions. However, fossil investigations suggest that we need to explain when and why diversity was lost at high latitudes to generate the LDG. Unfortunately, diversity lost scenarios in the Holarctic have been repeatedly proposed but not yet clearly demonstrated. Here, we use diversification approaches for both phylogenies and fossils to study the LDG of Testudines, Crocodilia and Lepidosauria. We show the LDG of these groups has varied over time, with high latitudes serving as a source of tropical diversity but suffering disproportionate extinction during transitional periods to cold climate. We outline the ‘asymmetric gradient of extinction and dispersal’ (AGED) framework, which contextualizes previous ideas behind the LDG under a time-variable scenario. We suggest the current steep LDG may be explained by the extinction of clades adapted to warmer conditions from the new temperate regions formed in the Neogene, together with the equator-ward dispersal of organisms tracking their own climatic preferences, when tropical biomes became restricted to the equator. Conversely, high rates of speciation and pole-ward dispersals can account for the formation of an ancient flat LDG during the Cretaceous–Paleogene greenhouse period. Our results demonstrate that the inclusion of fossils in macroevolutionary studies allows detecting extinction events less detectable in analyses restricted to present-day data only.
Assessment of therapeutic safety in systematic reviews: literature review
Authors: E. Ernst, M. H Pittler
Journal: BMJ (2001)

Evidence based medicine aims to objectively and continually evaluate all medical interventions with a view to incorporating the knowledge gained into routine healthcare practice.The ultimate goal is to enhance patient care.The most powerful tools used in evidence based medicine are systematic reviews and metaanalyses. 1 Generally, these studies focus on the efficacy or effectiveness of therapeutic interventions; indisputably, however, information on safety is equally important for making informed, evidence based decisions on the value of a given treatment.We evaluated two major medical databases to assess the extent to which therapeutic safety is addressed in systematic reviews and meta-analyses. Methods and resultsWe performed systematic literature searches to identify all systematic reviews and meta-analyses on the efficacy or effectiveness and the safety of any type of therapeutic intervention.Data sources were Medline (1966-December 2000) and the Cochrane Library (2000, issue 4).The title, abstract, and keywords of papers were searched using the terms efficacy, effectiveness, systematic review, meta-analysis, safety, adverse effect, adverse event, and adverse reaction and their derivatives.No language restrictions were imposed.The title and abstract of all studies were read and data were according to the criteria defined.Studies were included only if they stated that they were systematic reviews or meta-analyses or if they indicated that the available data were systematically searched for, appraised, and summarised.Studies that included no abstract or that provided no data on humans were excluded.Data were assessed according to the year of the study, and the studies were categorised into three categories: systematic reviews on efficacy or effectiveness, systematic reviews that
Grandfathers threatened with extinction
Authors: T. Smith
Journal: BMJ (1995)

Being a grandfather is a pleasure that creeps up unexpectedly on men at a time in their lives when most other events and experiences are negative—physical and mental aging; the loss of status, power, and money that comes with retirement; and the recognition that life expectation can now be measured with some accuracy in small numbers. Women, by contrast, seem to look forward to grandparenting as soon as their daughters are adult, wanting to be able to indulge a new generation of small children without having to take day to day responsibility for their care.

Grandparenting is, however, coming under threat from the consequences of several trends in childbearing which are changing Western society: …
The long noncoding RNA SChLAP1 promotes aggressive prostate cancer and antagonizes the SWI/SNF complex
Authors: John R Prensner, Matthew K Iyer, Anirban Sahu, Irfan A Asangani, Qi Cao, Lalit Patel, Ismael A Vergara, Elai Davicioni, Nicholas Erho, Mercedeh Ghadessi, Robert B Jenkins, Timothy J Triche, Rohit Malik, Rachel Bedenis, Natalie McGregor, Teng Ma, Wei Chen, Sumin Han, Xiaojun Jing, Xuhong Cao, Xiaoju Wang, Benjamin Chandler, Wei Yan, Javed Siddiqui, Lakshmi P Kunju, Saravana M Dhanasekaran, Kenneth J Pienta, Felix Y Feng, Arul M Chinnaiyan
Journal: Nature Genetics (2013)
Trial of strategy for reducing the use of laboratory tests
Authors: R. J Plumridge
Journal: BMJ (1986)

pyridoxine.56There is one published paper which showed that three out of eight subjects had an abnormal electroencephalogram eight -days after supplementation of pyridoxine 200 mg daily was stopped.7This study, performed in-1964, has been interpreted as showing that symptoms of dependency occur after withdrawal of pyridoxine treatment.These findings have not been reproduced, nor have practitioners with expenence of treating large series of patients with pyridoxine in doses of 20-150 mg encountered symptoms of dependency after cessation oftreatment (M Brush, personal communication).It is unfortunate that tables are modified for publication without the primary sources of reference being verified.This can result in un- substantiated effects being incorporated into published reports as fact, solely by virtue of repetition.
COMMON NEUROLOGICAL DISEASES SEEN IN GENERAL PRACTICE
Authors: Karl O. Von Hagen
Journal: JAMA (1952)

The commonest neurological condition seen by the clinician results from the various manifestations of cerebrovascular disease, which is due generally to some type of vascular anomaly, usually congenital, or to the complications of arteriosclerosis, with or without hypertension or heart disease, or to syphilis. Cerebral embolism is included in this group because the symptoms are due to some disturbance of cerebral circulation, because it has to be differentiated from other cerebral vascular lesions, and because the treatment is essentially the same as for cerebral thrombosis.  CEREBROVASCULAR ACCIDENTS  Intracranial but Extracerebral Hemorrhage.—  Hemorrhage occurring in the cranium but outside of the cerebrum is usually due to a congenital vascular anomaly but may be due to trauma or to rupture of a superficial sclerotic artery. The usual congenital anomaly is an aneurysm due to malformation in the arterial wall at the bifurcation of one of the vessels comprising the circle of Willis.
Analysis of hepatitis B viral load decline under potent therapy: Complex decay profiles observed
Authors: Sharon R. Lewin, Ruy M. Ribeiro, Tomos Walters, George K. Lau, Scott Bowden, Stephen Locarnini, Alan S. Perelson
Journal: Hepatology (2001)

We used a new real-time polymerase chain reaction (PCR)-based assay that is sensitive, has a wide dynamic linear range, and is highly reproducible to quantify hepatitis B virus (HBV) DNA in the serum of infected individuals undergoing potent antiviral therapy. In addition, we made frequent measurements of viral load after initiation of treatment and maintained follow-up to about 12 weeks. To analyze the data we used a new model of HBV decay, which takes into account that existing drug treatments do not completely block de novo infection and the possibility of noncytolytic loss of infected cells. On initiation of therapy, there was a mean delay of 1.6 days followed by a biphasic or muliphasic decay of plasma HBV DNA. The slope of the first phase varied considerably, with one individual having rapid decay, corresponding to a virion half-life of 1 hour, but others showing half-lives of up to 92 hours. Individuals either had a slow second-phase decline ( t ½ = 7.2 ± 1.2 days) or a flat second phase. Some individuals exhibited a complex “staircase pattern” of decay, with further phases of viral DNA decline and phases with little change in viral load.
Arsenic in Rice and Other Foods—Reply
Authors: Ana Navas-Acien, Keeve Nachman
Journal: JAMA Internal Medicine (2014)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Internal Medicine HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Internal Medicine journal
Poisoning—General Treatment and Prevention
Authors: Jay M. Arena
Journal: JAMA (1975)

THERE are not many effective, useful,<i>specific</i>antidotes for poisoning, and their overuse often complicates the initial injury by producing other forms of poisoning. As I mentioned in part I (232:1272,1975), sensible selection and use of drugs and other therapy for symptomatic and supportive treatment of poisoning are more likely to save lives than ill-considered and heroically applied therapy. Tables 1 and 2 list most of the general and all of the specific antidotes now available to the physician for emergency use, and these can be combined with the symptomatic and supportive drugs and measures on hand. The "universal antidote" of burnt toast (charcoal), milk of magnesia (magnesium hydroxide), and strong tea solution (tannic acid) is ineffective and obsolete. It can do more harm than good, mainly because it often gives a false sense of security, and because preparing and administering it takes up valuable time. <h3>Antibiotics</h3> Antibiotics are often
STUDIES ON THE DEVELOPMENT OF TOXICITY IN INTESTINAL SECRETION
Authors: David M. Davis, Harvey B. Stone
Journal: The Journal of Experimental Medicine (1917)

1. Intestinal secretion, collected by the method described in this paper, is non-toxic when fresh. 2. This secretion, when heated immediately to 90–95°C. and kept sterile, remains non-toxic. 3. This secretion, when not heated, remains non-toxic when kept under chloroform and toluene, even if incubated at 37°C. 4. This secretion, when not heated, but collected in a sterile flask, becomes toxic upon incubating 18 hours, producing symptoms like those of closed loop fluid. 5. The secretion, when treated with chloroform and toluene, and later incubated for 18 hours, after these preservatives have been removed by distillation at 60°C., does not produce lesions typical of closed loop fluid.
An Address ON THE STUDY OF TROPICAL DISEASES: DELIVERED AT THE OPENING OF THE WINTER SESSION OF THE LONDON SCHOOL OF TROPICAL MEDICINE
Authors: K. Macleod
Journal: BMJ (1906)

an address was delivered in this place by Sir Patrick Manson, whom I may without impropriety designate as the Brahma and Vishnu-the creator and sustainer-of the London School of Tropical Medicine.In that address Sir Patrick Manson described the origin, progress, and prospects of the institution, and indicated its objects, achievements, and requirements.The school, which was opened on October 3rd, 1899, had then completed the fourth year of its existence.An aggregate of 355 students had under- gone instruction during thirteen sessions, and evidence was produced of good work accomplished in the hospital and school, and by many of its alumni who had utilized to advantage the lessons, theoretical and practical, which they had been taught.During the three years which have elapsed since that address was delivered the school has continued to prosper.
A consensus definition of patients with metastatic urothelial carcinoma who are unfit for cisplatin-based chemotherapy
Authors: Matthew D Galsky, Noah M Hahn, Jonathan Rosenberg, Guru Sonpavde, Thomas Hutson, William K Oh, Robert Dreicer, Nicholas Vogelzang, Cora Sternberg, Dean F Bajorin, Joaquim Bellmunt
Journal: The Lancet Oncology (2011)
ELECTRON MICROSCOPIC STUDIES OF EXPERIMENTAL NEPHRITIS WITH FERRITIN-CONJUGATED ANTIBODY
Authors: Giuseppe A. Andres, Councilman Morgan, Konrad C. Hsu, Richard A. Rifkind, Beatrice C. Seegal
Journal: The Journal of Experimental Medicine (1962)

Ferritin-conjugated antibody has been used to identify by electron microscopy the sites at which nephrotoxic globulins localize in rat kidney during acute experimental glomerulonephritis. Antibody was concentrated in the glomerular basement membrane and in basement membrane-like material contained in distended cisternae of the endoplasmic reticulum. These data confirm and amplify, at the ultrastructural level, the results of studies obtained with the fluorescent antibody technique, and are consistent with the hypothesis that the cisternae and capillary basement membrane possess common proteins.
Dr Doubledose: a taste of one's own medicine
Authors: R. Porter
Journal: BMJ (1994)

Jokes, Freud taught us, are the acceptable face of aggression. Humour has, not surprisingly, provided a way for the people to fight back against the powerful; and, on account of their own highminded aspirations, the liberal and learned professions traditionally laid themselves particularly open to lampoon. Anti-priest and anti-doctor satire was not only a form of revenge, it was also designed to deflate, exposing pretension and humbug.

Medical satire was particularly near the bone since its humour was black. Laughter was a way of keeping the dread of death at bay—of handling the insidious suspicion that the medical profession might not after all be fighting death but could prove a double agent.

Such themes became specially prominent from the 18th century with the spread of fairly cheap prints and engravings alongside traditional verbal expressions like proverbs, riddles, and rhymes. Hogarth's commercial talents led the way from the 1730s. The decades around 1800 brought the golden age of the cartoon with Rowlandson, Gillray, and the Cruikshank family. The verbal and the visual joined forces to produce maximum impact in an age notably uninhibited in its depiction of sex and violence in political prints and professional satire alike.

The standing of early modern medics was precarious and it is not hard to see why. Disease and death still held sway. Faced with hordes of waterborne, airborne, and bugborne fevers, medicine had little power to cure the sick or save the dying. Doctors had to do their feeble best in a cut-throat trade, exposed to non-stop vilification. “If the world knew the villainy and knavery (beside ignorance) of the physicians and apothecaries,” the gossipy antiquarian John Aubrey was told by a doctor, “the people would throw stones at 'em as they walked in the streets.” Scepticism ran high: “God heals and the Doctors …
A CASE OF “ANGEIO-KERATOMA.”
Authors: WILLIAM ANDERSON
Journal: British Journal of Dermatology (1898)

Journal Article A CASE OF “ANGEIO‐KERATOMA.” Get access WILLIAM ANDERSON, F.R.C.S. WILLIAM ANDERSON, F.R.C.S. Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 10, Issue 4, 1 April 1898, Pages 113–117, https://doi.org/10.1111/j.1365-2133.1898.tb16317.x Published: 01 April 1898
Is the hygiene hypothesis still a viable explanation for the increased prevalence of asthma?
Authors: T. A. E. Platts‐Mills, E. Erwin, P. Heymann, J. Woodfolk
Journal: Allergy (2005)

The hygiene hypothesis states that a reduced exposure to allergens in early life is solely implicated in the growing propensity for allergy sensitization. Important elements of the hypothesis include helminth infection, exposure to endotoxins, exposure to pets and growing up on a farm. However, the hygiene hypothesis alone does not provide an adequate explanation for the observed increase in allergic disease. For example, in North American inner cities, asthma is increasing among children who live in very poor housing, which might be assumed to be somewhat dirty. In order to explain the increase in asthma, we need to take a broader view and also consider alterations related to the adoption of a western lifestyle. It has been suggested that lifestyle changes related to obesity (e.g. a change in diet) are associated with asthma. Other changes include a progressive decrease in physical activity. This lifestyle factor seems to correlate best with the recent increase in asthma. Clearly, the link between physical activity and asthma needs to be investigated in more detail.
Iraq blames Gulf war bombing for increase in child cancers
Authors: J. Ciment
Journal: BMJ (1998)

Iraqi health officials have claimed that depleted uranium weapons--used by the American and British military during the Gulf war--may be to blame for a substantial increase in the number of cancer cases in the southern part of the country. Depleted uranium--the byproduct of nuclear weapons and power generation--is used to make shells heavier and denser so that they can pierce tank armour more effectively.

“The use of depleted uranium has caused irreparable damage to …