CLINICAL DISORDERS OF THE NEUROHYPOPHYSIS
Authors: T FINDLEY
Journal: Annals of Internal Medicine (1950)

Article1 December 1950CLINICAL DISORDERS OF THE NEUROHYPOPHYSISTHOMAS FINDLEY, M.D., F.A.C.P.THOMAS FINDLEY, M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-33-6-1423 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptDiabetes insipidus is the only clinical disorder generally conceded to be of neurohypophyseal origin, but accumulating evidence suggests that the neurohypophysis may have functions now scarcely appreciated. If such functions exist, they appear to be anti-adrenocortical in nature. The experimental data supporting such speculation are meager and largely unconfirmed, but a considerable body of clinical information can be interpreted in a corroborative manner. In view of the current emphasis upon hyperadrenocorticism in its various forms, it would seem important not to overlook the possible existence of antagonistic homeostatic mechanisms. The purpose of this paper is to suggest that we may...Bibliography1. FisherIngramRansom CWRSW: Diabetes insipidus and the neuro-hormonal control of water balance, Ann Arbor, Edwards Bros., 1938. CrossrefGoogle Scholar2. Albright F: Cushing's syndrome; its pathological physiology, its relationship to adrenogenital syndrome, and its connection with problem of reaction of body to injurious agents ("alarm reaction" of Selye), Harvey Lec. (1942-1943) 38: 123, 1943. Google Scholar3. Brobeck JR: Mechanism of development of obesity in animals with hypothalamic lesion, Physiol. Rev. 26: 541, 1946. CrossrefMedlineGoogle Scholar4. Stevenson JA: Effects of hypothalamic lesions on water and energy metabolism in rat, Recent Progress in Hormone Research 4: 363, 1949. Google Scholar5. HeinbeckerWhiteRolf PHLD: Experimental obesity in dogs, Am. J. Physiol. 141: 549, 1944. CrossrefGoogle Scholar6. Heinbecker P: Pathogenesis of Cushing's syndrome, Medicine 23: 225, 1944. CrossrefGoogle Scholar7. Heinbecker P: The pathogenesis of diastolic hypertension, Surgery 23: 618, 1948. MedlineGoogle Scholar8. TeppermanBrobeckLong JJRCN: Effects of hypothalamic hyperphagia and of alterations in feeding habits on metabolism of albino rat, Yale J. Biol. and Med. 15: 855, 1943. MedlineGoogle Scholar9. BarrisIngram RWWR: Effect of experimental hypothalamic lesions upon blood sugar, Am. J. Physiol. 114: 555, 1936. CrossrefGoogle Scholar10. RansonFisherIngram SWCWR: Adiposity and diabetes mellitus in monkey with hypothalamic lesions, Endocrinology 23: 175, 1938. CrossrefGoogle Scholar11. Heinbecker P: Cushing's syndrome, Ann. Surg. 124: 252, 1946. CrossrefGoogle Scholar12. MorganVonderaheMalone LOAREF: Pathological changes in hypothalamus in diabetes mellitus; study of 15 cases, J. Nerv. and Ment. Dis. 85: 125, 1937. CrossrefGoogle Scholar13. Fry HJ: The pituitary gland in diabetes mellitus and disorders of the glands of internal secretion, Quart. J. Med. 8: 277, 1915. CrossrefGoogle Scholar14. McPherson E: Case of diabetes mellitus, associated with lesions of the pituitary body, Glasgow M.J. 131: 220, 1939. MedlineGoogle Scholar15. Warren S: Pathology of diabetes mellitus, Baltimore, Lea & Febiger, 1930, p. 194. Google Scholar16. Mellgren J: Anterior pituitary in hyperfunction of adrenal cortex; anatomical study with special reference to syndroma Morgagni and notes on prostatic hypertrophy, Acta path. et microbiol. Scandinav., 1945, supp. 60, pp. 1. Google Scholar17. HeinbeckerWhiteRolf PHLD: Essential lesion in experimental diabetes insipidus, Endocrinology 40: 104, 1947. CrossrefMedlineGoogle Scholar18. SilvetteBritton HSW: Renal function in opossums and mechanism of corticoadrenal and postpituitary action, Am. J. Physiol. 123: 630, 1938. CrossrefGoogle Scholar19. Findley T: Role of the neurohypophysis in the pathogenesis of hypertension and some allied disorders associated with aging, Am. J. Med. 7: 70, 1949. CrossrefMedlineGoogle Scholar20. Birnie JH: An antidiuretic substance in the blood of normal and adrenalectomized rats, Proc. Soc. Exper. Biol. and Med. 70: 83, 1949. CrossrefMedlineGoogle Scholar21. RoemmeltSartoriusPitts JCOWRF: Excretion and reabsorption of sodium and water in the adrenalectomized dog, Am. J. Physiol. 159: 124, 1949. CrossrefMedlineGoogle Scholar22. Peters JP: The significance of serum sodium, McGill M. J. 18: 130, 1949. MedlineGoogle Scholar23. Peters JP: The role of sodium in the production of edema, New England J. Med. 239: 353, 1948. CrossrefMedlineGoogle Scholar24. Brooks CM: Relation of hypothalamus to gonadotropic functions of hypophysis, A. Research Nerv. and Ment. Dis. Proc. (1939) 20: 525, 1940. Google Scholar25. Bard P: Hypothalamus and sexual behavior, A. Research Nerv. and Ment. Dis. Proc. (1939) 20: 551, 1940. Google Scholar26. Albright F: Carcinoma of adrenal cortex, New England J. Med. 241: 874, 1949. MedlineGoogle Scholar27. SeckelScottBenditt HPWWEP: Six examples of precocious sexual development; studies in diagnosis and pathogenesis, Am. J. Dis. Child. 78: 484, 1949. MedlineGoogle Scholar28. AndersonHaymakerRappaport EWH: Seminiferous tubule failure associated with degenerative change in the hypothalamus, Am. Pract. 1: 40, 1950. Google Scholar29. Heinbecker P: Personal communication. Google Scholar30. Liu SH: Pathological states produced by administration of posterior pituitary pressor principle, Chinese M. J. 55: 448, 1939. Google Scholar31. Heinbecker P: The pathogenesis of hyperthyroidism, Ann. Surg. 130: 804, 1949. CrossrefGoogle Scholar32. KellerLawrenceBlair ADWECB: Effects of varying degrees of hypophysectomy in dog, Arch. Path. 40: 289, 1945. Google Scholar33. Hume DM: The role of the hypothalamus in the pituitary-adrenal cortical response to stress, J. Clin. Investigation 28: 790, 1949. Google Scholar34. Harrisde Groot GWJ: Hypothalamic control of the secretion of adrenocorticotropic hormone, Federation Proc. 9: 57, 1950. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: New Orleans, Louisiana*Presented at the Thirty-first Annual Session of the American College of Physicians, Boston, Mass., April 19, 1950.From the Departments of Internal Medicine, Ochsner Clinic and Tulane University of Louisiana, School of Medicine, New Orleans. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byDiabetes insipidus und primäre Oligurie (Antidiabetes insipidus) 1 December 1950Volume 33, Issue 6Page: 1423-1430 Issue Published: 1 December 1950 PDF downloadLoading ...