tbuckley/cabot-search huggingface dataset:
The Retinal Venous Pulse
Authors: Thomas R. Hedges, Edward M. Baron, Thomas R. Hedges, Stephen H. Sinclair
Journal: Ophthalmology (1994)

The presence or absence of the spontaneous retinal venous pulse is an important clinical sign, especially when one is evaluating a patient who may have increased intracranial pressure. The purpose of this study is to evaluate a large group of healthy patients, correlating optic disc characteristics, choroidal pulse, and brachial pulse pressure with the presence and intensity of the spontaneous retinal venous pulse.Ninety-seven patients were studied correlating these parameters with their fundus photographs. Ocular pneumotonometry as a measure of the choroidal pulse and the brachial pulse pressure were correlated with the optic disc characteristics and the intensity of the retinal venous pulse statistically.The results showed a highly significant correlation with these parameters. The greater the pulse amplitude--especially the choroidal pulse the more likely the spontaneous retinal venous pulse would be present. More importantly, the anatomic variable of optic disc cup and vascular configuration had the greatest influence on whether the spontaneous retinal venous pulse is present or absent.The authors conclude that unless the clinician is aware of the importance of optic nerve characteristics and pulse amplitude in the choroid (indirectly measured in a normal clinical setting by the brachial pulse) the significance of the spontaneous retinal venous pulse cannot be properly determined.
DIABETIC COMA—A THERAPEUTIC PROBLEM
Authors: G G DUNCAN
Journal: Annals of Internal Medicine (1952)

Article1 December 1952DIABETIC COMA—A THERAPEUTIC PROBLEMGARFIELD G. DUNCAN, M.D., F.A.C.P.GARFIELD G. DUNCAN, M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-37-6-1188 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThere is a wide disparity in the mortality rates from diabetic coma, varying from approximately 1 per cent to as much as 50 per cent in presumably reputable hospitals. Low mortality rates are widely publicized but high rates are not. It is a safe conjecture that high rates would not be uncommon in a country-wide survey. If this surmise is correct, it would appear that fatalities from diabetic coma occur for want of an early diagnosis and early treatment, for want of specially trained personnel, and possibly, but not so likely, for want of laboratory facilities or a combination of...Bibliography1. Harwood R: Diabetic acidosis, New England J. Med. 245: 1, 1951. CrossrefMedlineGoogle Scholar2. RootStoryCortesi HFRDJB: Diabetic coma versus diabetic nephropathy, New England J. Med. 245: 765, 1951. CrossrefMedlineGoogle Scholar3. Butler AM: Diabetic coma, New England J. Med. 243: 648, 1950. CrossrefMedlineGoogle Scholar4. BelletNadlerGazesLanning SCSPCM: Effect of vomiting due to intestinal obstruction on the serum potassium, Am. J. Med. 6: 712, 1949. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Philadelphia, Pennsylvania*From the Symposium on Diabetes presented at the Thirty-third Annual Session of the American College of Physicians, Cleveland, Ohio, April 25, 1952. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byFirst Descriptions of Initial ManagementA paper which changed clinical practice (slowly). Jacob Holler on potassium deficiency in diabetic acidosis (1946)Coma diabeticumDie Insulintherapie: Die Behandlung des Coma diabeticumDIABETIC ACIDOSIS: AN EVALUATION OF THE CAUSE, COURSE AND THERAPY OF 73 CASES*ALAN S. COHEN, M.D., VERNON K. VANCE, M.D., JOHN W. RUNYAN JR., M.D., F.A.C.P., DAVID HURWITZ, M.D.The Impact of Emergency Surgery on Patients with Pre-Existing DiseaseANTIBIOTIC PREVENTION OF INTERCURRENT INFECTIONS IN DIABETES MELLITUS*LEON V. MCVAY JR., M.D., DOUGLAS H. SPRUNT, M.D., F.A.C.P., THOMAS N. STERN, M.D., FREDERICK E. TATUM, M.D., ALYS LIPSCOMB, M.D. 1 December 1952Volume 37, Issue 6Page: 1188-1196KeywordsComaDeath ratesResearch laboratories ePublished: 1 December 2008 Issue Published: 1 December 1952 PDF downloadLoading ...
HSP70 stimulates cytokine production through a CD14-dependant pathway, demonstrating its dual role as a chaperone and cytokine
Authors: Alexzander Asea, Stine-Kathrein Kraeft, Evelyn A. Kurt-Jones, Mary Ann Stevenson, Lan Bo Chen, Robert W. Finberg, Gloria C. Koo, Stuart K. Calderwood
Journal: Nature Medicine (2000)
Abstract 1620: Impact of Diastolic Dysfunction on the Development of Heart Failure in Diabetic Patients After Acute Myocardial Infarction
Authors: Doron Aronson, Anees Musallam, Haim Hammerman, Yoram Agmon, Diab Mutlak
Journal: Circulation (2009)

Background: Diabetic patients (pts) are at increased risk for heart failure (HF) after acute myocardial infarction (AMI). The greater propensity for HF in diabetic pts may be due to left ventricular diastolic dysfunction. However, there is no data regarding the prevalence and clinical consequences of diastolic dysfunction in diabetic pts with AMI.  Methods: We studied 1513 pts after AMI (417 diabetic). Echocardiography was performed during hospital stay. Diastolic dysfunction was defined as a restrictive filling pattern (RFP) based on E/A ratio >1.5 or deceleration time   Results: The frequency of RFP was higher in pts with diabetes (20 vs. 14%; P=0.005). During a mean follow up of 18 months (range 6 to 39) 114 pts developed HF. There was a significant interaction between diabetes and RFP with regard to HF (P=0.04), such that the relationship between diabetes and HF was much stronger among pts with RFP (Figure). In the whole study population, the HR for HF was 1.6 in diabetic compared with nondiabetic pts (95% CI 1.1 to 2.3; P=0.02). In stratified analyses, compared with nondiabetic pts, the adjusted HR for HF was 2.8 in diabetic pts with RFP (95% CI, 1.4 to 5.5; P=0.002) and 1.2 in diabetic pts without RFP (95% CI, 0.8 to 1.6; P=0.34).  Conclusion: Diabetic pts with AMI have a higher prevalence of RFP. The excess of HF events among diabetic pts occur predominantly in pts with concomitant RFP.
Improving the Quality of Data in Surgical Registries
Authors: Philip P. Goodney
Journal: JAMA Surgery (2015)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Surgery HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Surgery journal
Abstract 4252: Regulation of the oncogene ZNF217 by localization in breast cancer
Authors: Matthew J. Messana, Chao Yang, Laurie E. Littlepage
Journal: Cancer Research (2014)

Abstract Poor prognosis in breast cancer patients occurs when malignant tumors adapt to environmental insults, become resistant to chemotherapy, evade immune surveillance and metastasize to other tissues. Tumors are thought to arise from individual cells with multiple mutations, including amplification of genomic regions that provide a growth advantage. A region on human chromosome 20 called 20q13 is increased in ∼25% of early stage human breast cancers and correlates with poor prognosis in patients. We have studied a novel oncogene ZNF217 within this region. ZNF217 is key in promoting breast cancer: it is not only a prognostic indicator of breast cancer progression in patients who have the worst prognosis but also is itself a drug target and/or a marker of patient response to therapy. We find that ZNF217 protein is expressed most strongly in a small subset of cells within normal mammary epithelium and localizes predominantly in the nucleus of mammary epithelial cells. In contrast, the localization of ZNF217 is heterogeneous in breast tumors, with localization in both the nucleus and cytoplasm. Moreover, a truncated form of the protein localizes exclusively in the cytoplasm. We hypothesize that ZNF217 cytoplasmic localization affects ZNF217 function during cancer progression and can be used to predict poor prognosis in breast cancer patients. Thus, our first aim is to identify the regions of ZNF217 that are required for ZNF217 localization in the nucleus and cytoplasm. Second, we will utilize integrated biological approaches to determine the consequences of mislocalization of ZNF217 on cancer progression. We will determine which regions of ZNF217 are required for oncogenesis by overexpressing ZNF217 truncations in mammary epithelial cells and using these cells in a variety of assays that model steps in cancer progression_assays that have previously shown that ZNF217 promotes cancer progression. If our data shows that the cytoplasmic ZNF217 is implicated in oncogenesis, further studies will be required to identify the mechanisms by which ZNF217 is truncated in cells. Hopefully, this will aid in the development of innovative cancer diagnostics and therapeutics for breast cancer and other cancers. Citation Format: Matthew J. Messana, Chao Yang, Laurie E. Littlepage. Regulation of the oncogene ZNF217 by localization in breast cancer. [abstract]. In: Proceedings of the 105th Annual Meeting of the American Association for Cancer Research; 2014 Apr 5-9; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2014;74(19 Suppl):Abstract nr 4252. doi:10.1158/1538-7445.AM2014-4252
Abstract 12458: Pharmacodynamic Effects of Dabigatran in Patients With Coronary Artery Disease on Dual Antiplatelet Therapy With Aspirin and Clopidogrel
Authors: Francesco Franchi, Fabiana Rollini, Jung Rae Cho, Mona Bhatti, Christopher DeGroat, Antonio Tello-Montoliu, Valeria Duarte, Estela Thano, Gabriel Faz, Martin M Zenni, Luis A Guzman, Ramzi Ajjan, Theodore A Bass, Dominick J Angiolillo
Journal: Circulation (2014)

Background:The use of vitamin K antagonists (VKAs) in patients on dual antiplatelet therapy (DAPT) with aspirin and clopidogrel is associated with an increased risk of bleeding, myocardial infarction and mortality. Moreover, VKAs interfere with clopidogrel metabolism via the cytochrome P450 (CYP) system leading to increased platelet reactivity. The direct thrombin inhibitor dabigatran does not interfere with the CYP system and has a favorable safety and efficacy profile compared with VKAs. However, the pharmacodynamic (PD) effects of adjunctive dabigatran therapy in patients on DAPT is unknown. Methods: This was a prospective, randomized, double-blind PD study conducted in patients on maintenance (>30 days) DAPT with aspirin (81mg/qd) and clopidogrel (75mg/qd). Patients (n=30) were randomized to receive either dabigatran 150mg bid or matching placebo for 7 days. PD testing was performed before and after treatment using 3 different assays: kaolin-activated thromboelastography (TEG); light transmission aggr...
Coping with the aftermath of trauma: Authors' reply
Authors: Berthold P R Gersons, Miranda Olff
Journal: BMJ (2005)

EDITOR—Summerfield (and Hopkins et al, in their electronic response1) criticise the narrow, biomedical approach of the guidelines from the National Institute for Health and Clinical Excellence (NICE). Summerfield especially argues that the guideline is fundamentally flawed because the problems of a person, even many years after traumatic experiences, are framed within the diagnosis of post-traumatic stress disorder.

Psychological treatment for post-traumatic …
Phenotype and function of human hematopoietic cells engrafting immune- deficient CB17-severe combined immunodeficiency mice and nonobese diabetic-severe combined immunodeficiency mice after transplantation of human cord blood mononuclear cells
Authors: F Pflumio, B Izac, A Katz, LD Shultz, W Vainchenker, L Coulombel
Journal: Blood (1996)
A memorable patient: How a refugee community deals with adoption
Authors: R. McGready
Journal: BMJ (2003)

On the western border of Thailand more than 100 000 people of the Karen ethnic minority from Burma live in camps for refugees. Karen people are predominantly Animist or Buddhist. Some of the educated ones are Christian, but Animism remains a pervasive influence in most Karens' lives. Literacy among adult women is poor. Children go to school; couples marry and have children—a blessing for Karen people.

Naw Mu was an 18 year old Karen woman attending the antenatal clinics in Maela Refugee Camp. She had essential hypertension and, at 33 weeks gestation, developed …
Atopik ve atopiform dermatit arasındaki klinik farklılıklar
Authors: Elian E. A. Brenninkmeijer, Phyllis I. Spuls, Catharina M. Legierse, Robert Lindeboom, J. Henk Sillevis Smitt, veJan D. Bos Amsterdam
Journal: Journal of the American Academy of Dermatology (2008)
PANCREATITIS: AN ANALYSIS OF TYPES AND CAUSES
Authors: Kenneth M. Lynch
Journal: Annals of Internal Medicine (1940)

Article1 October 1940PANCREATITIS: AN ANALYSIS OF TYPES AND CAUSESKENNETH M. LYNCH, F.A.C.P.KENNETH M. LYNCH, F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-14-4-628 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe picture brought to mind by the term acute pancreatitis is that of a necrotic, hemorrhagic gland, in the extreme state gangrenous, which has produced an upper abdominal catastrophe with severe pain and tenderness, collapse and death.In fact the very names used to designate acute disease of the pancreas carry the significance of extreme disease, thusacute hemorrhagicpancreatitis or, more recently in usage,acute hemorrhagic necrosis, whereas in actual anatomical study neither hemorrhage nor necrosis of conspicuous degree need be found. Consequently, the older name,acute pancreatitismay still be considered a better one to designate the class,...References1. OPIE EL: The etiology of acute hemorrhagic pancreatitis, Bull. Johns Hopkins Hosp., 1901, xii, 182. Google Scholar2. RICHDUFF ARGL: Experimental and pathologic studies on the pathogenesis of hemorrhagic pancreatitis, Bull. Johns Hopkins Hosp., 1936, lviii, 212. Google Scholar3. WEINERTENNANT HAR: A statistical study of acute hemorrhagic pancreatitis (hemorrhagic necrosis of pancreas), Am. Jr. Med. Sci., 1938, cxcvi, 167. CrossrefGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Charleston, S. C.*Read before the American College of Physicians, Cleveland, April 2, 1940.From the Department of Pathology of the Medical College of the State of South Carolina. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byHistopathological study of pancreatic ischemic lesions induced by cholesterol emboli: Fresh and subsequent features of pancreatic ischemiaAcute Hyperparathyroidism and Acute PancreatitisInfarcts of the PancreasDie Krankheiten der Bauchspeicheldrüse 1 October 1940Volume 14, Issue 4Page: 628-640KeywordsAbdominal painAcute pancreatitisHemorrhageNecrosisPancreasPancreatitis ePublished: 1 December 2008 Issue Published: 1 October 1940 PDF downloadLoading ...
Funding of hospital equipment underfunded by £8m in Scotland
Authors: Bryan Christie
Journal: BMJ (2001)

Hospitals in Scotland are failing to invest adequately in medical equipment, which could result in putting patients at risk, says a report from the Auditor General for Scotland. It has recommended the establishment of a rolling programme of planned replacement.

Underfunding of around £8m ($12m) was identified in 1997-8. Although the report acknowledges that figures for one year need to be treated with caution, it added: “Our survey findings suggest that across Scotland, expenditure on new …
Particulate cytoplasmic structures with high concentration of ubiquitin-proteasome accumulate in myeloid neoplasms
Authors: Alessandro Pecci, Vittorio Necchi, Serena Barozzi, Agostina Vitali, Emanuela Boveri, Chiara Elena, Paolo Bernasconi, Patrizia Noris, Enrico Solcia
Journal: Journal of Hematology & Oncology (2015)

Increased plasma levels of proteasome have been associated with various neoplasms, especially myeloid malignancies. Little is known of the cellular origin and release mechanisms of such proteasome. We recently identified and characterized a novel particulate cytoplasmic structure (PaCS) showing selective accumulation of ubiquitin-proteasome system (UPS) components. PaCSs have been reported in some epithelial neoplasms and in two genetic disorders characterized by hematopoietic cell dysplasia and increased risk of leukemia. However, no information is available about PaCSs in hematopoietic neoplasms. PaCSs were investigated by ultrastructural, immunogold, and immunofluorescence analysis of bone marrow (BM) biopsies and peripheral blood (PB) cell preparations of 33 consecutive, untreated, or relapsed patients affected by different hematopoietic neoplasms. BM and PB samples from individuals with non-neoplastic BM or healthy donors were studied as controls. Granulocytes and platelet proteasome content was measured by immunoblotting and plasma proteasome levels by ELISA. PaCSs with typical, selective immunoreactivity for polyubiquitinated proteins and proteasome were widespread in granulocytic cells, megakaryocytes, and platelets of patients with myeloproliferative neoplasms (MPN). In acute myeloid leukemia and myelodysplastic syndromes (MDS), PaCSs were only occasionally detected in blast cells and were found consistently in cells showing granulocytic and megakaryocytic maturation. Conversely, PaCSs were poorly represented or absent in non-neoplastic hematopoietic tissue or lymphoid neoplasms. In MPN granulocytes and platelets, the presence of PaCSs was associated with increased amounts of proteasome in cell lysates. PaCSs were often localized in cytoplasmic blebs generating PaCSs-filled plasma membrane vesicles observable in the BM intercellular space. In MPN and MDS, accumulation of PaCSs was associated with significant increase in plasma proteasome. Immunogold analysis showed that PaCSs of myeloid neoplasia selectively concentrated the chaperone proteins Hsp40, Hsp70, and Hsp90. PaCSs accumulate in cells of myeloid neoplasms in a lineage- and maturation-restricted manner; in particular, they are widespread in granulocytic and megakaryocytic lineages of MPN patients. PaCSs development was associated with excess accumulation of polyubiquitinated proteins, proteasome, and chaperone molecules, indicating impairment of the UPS-dependent protein homeostasis and a possible link with Hsp90-related leukemogenesis. A mechanism of PaCSs discharge by leukemic cells could contribute to increased plasma proteasome of MPN and MDS.
272. Development of “Full”-Closed Sterile and Automatic Retroviral Gene Transfer System for Clinical Gene Therapy
Authors: Shin Kaneko, Makoto Otsu, Yuichi Hasegawa, Hiroshi Kojima, Takashi Shimizu, Takashi Fukushima, Ryo Sumazaki, Masafumi Onodera, Toshiro Nagasawa
Journal: Molecular Therapy (2004)

Manipulating large number of cultured cells for gene therapy has risk of microbiological contamination constantly. It would become more serious under the situation like re-infusion of such cells to the compromised host. Our clinical protocol, HSV-TK gene transfer into donor lymphocytes for control of allogeneic Graft-versus-leukemia and Graft-versus-host-disease (Japanese trial), is one of such sensitive protocol by meaning of immunological conditions of patients and manipulation steps. To avoid those problems we are developing manipulation protocol for retroviral gene transfer to human T lymphocytes using automatic cell processor CytoMateTM, magnetic cell selection system IsolexTM and CO2 permeable cell culture bag OpticytoTM. All of manipulations, except centrifugation for gene transfer, had been performed in full-closed sterile conditions. Function and sterility of final products, HSV-TK gene transferred lymphocytes, were evaluated by comparing with non-closed system, using centrifugation tubes and flasks.
The natural history of alcohol abuse: implications for definitions of alcohol use disorders
Authors: D S Hasin, B Grant, J Endicott
Journal: American Journal of Psychiatry (1990)

Is the DSM-III-R category of alcohol abuse validly differentiated from the DSM-III-R category of alcohol dependence, or is abuse primarily a mild, prodromal condition that typically deteriorates into dependence? A 4-year longitudinal epidemiologic study of male drinkers provided data to answer this question. The study used identical questions at baseline and follow-up. At follow-up, 70% of the subjects who were initially classified as alcohol abusers were still abusers or were classified as remitted. This contrasted significantly with outcome in the subjects who initially reported alcohol dependence. Although additional research is needed, these results indicate that alcohol abuse often has a course distinct from that of alcohol dependence.
Atopic dermo-respiratory syndrome is a correlate of eczema herpeticum
Authors: T. Hinz, D. Zaccaro, M. Byron, K. Brendes, T. Krieg, N. Novak, T. Bieber
Journal: Allergy (2011)

To cite this article: Hinz T, Zaccaro D, Byron M, Brendes K, Krieg T, Novak N, Bieber T. Atopic dermo-respiratory syndrome is a correlate of eczema herpeticum. Allergy 2011; 66: 925–933. Background: Factors favoring the emergence of eczema herpeticum (EH) in patients with atopic dermatitis (AD) remain elusive. The aim of this work was to identify changes in clinical and laboratory parameters in acute EH patients, before and after 6 weeks of treatment, as well as differences between AD patients with and without a history of EH. Methods: A total of 235 adult subjects were included and subdivided into six groups: (i) AD patients with acute EH, (ii) AD patients with history of EH, (iii) AD without EH but with recurrent herpes simplex virus (HSV) infections, (iv) AD without EH or recurrent HSV infections and healthy non-AD controls (v) with and (vi) without recurrent HSV infections. Clinical examination of AD, assessment of atopic status and severity were performed. Total IgE, allergen-specific IgE and differential blood count were analyzed. Clinical diagnosis of acute EH was confirmed by PCR. Results: More male patients with AD were affected by EH than female patients. Acute episodes of EH are characterized by lower levels of lymphocytes and higher levels of monocytes. AD patients with history of EH display higher total IgE serum levels (ADEH+HSV+vs ADEH−HSV+, P < 0.001) and higher sensitization profiles and stronger severity of AD (EASI and SCORAD; ADEH+HSV+vs ADEH−HSV+, P < 0.001). Concomitant asthma and rhinitis were identified as correlates of EH. Conclusion: From these data, we conclude that AD patients with EH display a distinct clinical and biological phenotype.
Quantitation of human cytomegalovirus DNA in peripheral blood leukocytes of heart transplant recipients: relationship with pp65 antigenernia and with antiviral therapy
Authors: Valeria Ghisetti, Anna Barbui, Fabrizia Pittaluga, Enrico Donegani, Marco Bobbio, Michele di Summa, Giovanna Marchiaro
Journal: Clinical Microbiology and Infection (1999)