tbuckley/cabot-search huggingface dataset:
Abstract 4243: EGFR inhibition causes growth delay and induces apoptosis in HPV-positive head and neck cancer
Authors: Alexandra D. Torres Law, Grace C. Blitzer, Molly A. Smith, Eric A. Armstrong, Randall J. Kimple
Journal: Cancer Research (2014)

Abstract Purpose: Cetuximab, a monoclonal antibody inhibiting the epidermal growth factor receptor (EGFR), is approved for use in the treatment of head and neck cancer (HNC). However, studies of cetuximab were performed with HPV-negative cells, clinical trials were performed without regard to HPV status, and current studies on HPV+ HNC treatment with cetuximab are contradicting. This study was performed to determine whether HPV+ HNC responds to cetuximab and to examine the mechanisms through which cetuximab affects HPV+ HNC. Methods: Four HPV+ cell lines were assessed for EGFR expression by immunoblot. Sensitivity to cetuximab was tested by examining cell proliferation and colony formation. Apoptosis was measured by caspase activation, flow cytometry for Annexin V, and immunoblot. Cell cycle was assessed by immunoblot and flow cytometry for propidium iodide stained cells. HPV+ HNC subcutaneous flank cell line xenografts and patient-derived xenografts were placed in immunocompromised mice treated with cetuximab, tumor size was measured twice weekly. Results: Cetuximab treatment resulted in significant delay in cell proliferation and significant decrease in colony formation. Cetuximab caused an increase in apoptosis in all methods measured. Also, as previously seen in HPV- cell lines, cetuximab resulted in a G1 cell cycle arrest. Using both cell line and patient-derived xenograft models of HPV+ HNCs, cetuximab resulted in significant tumor growth delay (median time to tumor quadrupling: 15 vs. 24 days, and 42 vs. 89 days, respectively). Conclusions: Epidermal growth factor receptor inhibition by cetuximab is effective in slowing proliferation and inducing apoptosis in HPV+ HNC. The proposed mechanism of action appears to be similar to that shown in HPV- HNC. These results suggest that cetuximab may play a role in the management of patients with HPV+ HNC. Citation Format: Alexandra D. Torres Law, Grace C. Blitzer, Molly A. Smith, Eric A. Armstrong, Randall J. Kimple. EGFR inhibition causes growth delay and induces apoptosis in HPV-positive head and neck cancer. [abstract]. In: Proceedings of the 105th Annual Meeting of the American Association for Cancer Research; 2014 Apr 5-9; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2014;74(19 Suppl):Abstract nr 4243. doi:10.1158/1538-7445.AM2014-4243
Genital Lesions of Primary Syphilis
Authors: Robert A Gunn, Thomas A Peterman, Kimberly A Workowski
Journal: JAMA (2004)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
THE EFFECTS OF CHRONIC PENTAPYRROLIDINIUM-INDUCED HYPOTENSION ON RENAL HEMODYNAMICS AND ON THE EXCRETION OF WATER AND ELECTROLYTES IN HYPERTENSION
Authors: J W STOVER, R W GRIFFIN, R V FORD
Journal: Annals of Internal Medicine (1956)

Article1 May 1956THE EFFECTS OF CHRONIC PENTAPYRROLIDINIUM-INDUCED HYPOTENSION ON RENAL HEMODYNAMICS AND ON THE EXCRETION OF WATER AND ELECTROLYTES IN HYPERTENSIONJOHN W. STOVER, M.D., ROBERT W. GRIFFIN, M.D., RALPH V. FORD, M.D.JOHN W. STOVER, M.D., ROBERT W. GRIFFIN, M.D., RALPH V. FORD, M.D.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-44-5-893 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe aggressive treatment of hypertensive disease has come to occupy a more prominent part in the clinician's interest. This is due to the availability of potent antihypertensive agents. In some instances the enthusiasm of the clinician has been dampened by the observation of increased renal insufficiency accompanying a marked reduction of blood pressure. The occurrence of uremia has been observed more commonly in patients treated with ganglionic blocking agents because: (1) the drugs are quite potent in reducing blood pressure, and (2) the patients requiring treatment with these agents are more likely to have severe hypertensive disease, which is accompanied...Bibliography1. FordMoyerSpurr RVJHCL: Hexamethonium in the chronic treatment of hypertension—its effect on renal hemodynamics and on the excretion of water and electrolytes, J. Clin. Investigation 32: 1133, 1953. CrossrefMedlineGoogle Scholar2. MoyerMills JHLC: Hexamethonium—its effect on glomerular filtration rate, maximal tubular function, and renal excretion of electrolytes, J. Clin. Investigation 32: 172, 1953. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: JOHN W. STOVER, M.D.; ROBERT W. GRIFFIN, M.D.; RALPH V. FORD, M.D.Affiliations: Houston, Texas*Received for publication November 2, 1955.From the Department of Medicine, Baylor University College of Medicine, and Veterans Administration Hospital, Houston, Texas.†Present address: San Antonio, Texas.‡Supplied as Ansolysen by Wyeth Laboratories, Incorporated. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byPhysiology of the kidneyRENAL HÆMODYNAMIC EFFECTS OF HYPOTENSIVE DRUGS 1 May 1956Volume 44, Issue 5Page: 893-898KeywordsBlood plasmaBlood pressureExcretionHemodynamicsHospital medicineHypertensionOral administrationRenal diseasesSaltsVasodilation ePublished: 1 December 2008 Issue Published: 1 May 1956 PDF downloadLoading ...
Abstract 220: Comparison of 3 Cognitive Exams in Cardiac Arrest Survivors
Authors: Allison Koller, Jon Rittenberger, Patrick Morgan, Melissa Repine, Jeffrey Kristan, Clifton Callaway
Journal: Circulation (2014)

Background: Cognitive deficits may detract from quality of life after cardiac arrest (CA). The pattern and prevalence of these deficits are not well documented. We used the Computer Assessment of Mild Cognitive Impairment (CAMCI), the Montreal Cognitive Assessment (MOCA) and the 41 Cent Test to assess cognitive impairment in survivors of CA. We hypothesized that CAMCI subscales and other scores that were highly correlated could identify specific domains of impairment in CA survivors. Methods: Four researchers administered the CAMCI, MOCA, and/or the 41 Cent Test to CA survivors after discharge from the intensive care unit between 2010 and 2014. Physicians screened patients with the Mini-Mental State Exam to determine when this cognitive testing was feasible. We compared the distribution of scores between patients who presented with coma and those who awoke immediately after CA. Pairwise correlations between the different subscales and tests were considered significant with alpha error of 0.05. Results: Ninety-two participants completed the CAMCI, of which 18 participants completed the CAMCI, MOCA and 41 Cent Test. The mean (SD) percentile score for CAMCI was 32.2 (20.3) out of possible 100, for the MOCA was 20.3 (5.2) out of a possible 30 points and the 41 Cent Test was 5.4 (1.1) out of a possible 7 points. MOCA correlated strongly with the overall CAMCI score (r = 0.82) and with the executive accuracy subscale of the CAMCI (r = 0.75). The executive accuracy subscale and overall CAMCI score correlated with one another (r = 0.81) when all 92 CAMCI exams were considered. The MOCA and 41 Cent Test were correlated with each other (r = 0.63). Conclusion: The CAMCI detects cognitive impairment after CA; the MOCA correlates strongly with the overall CAMCI and the executive function subscale of the CAMCI. The 41 Cent Test may not be as effective as the MOCA in detecting cognitive deficits.
Medical marijuana laws and adolescent marijuana use in the USA from 1991 to 2014: results from annual, repeated cross-sectional surveys
Authors: Deborah S Hasin, Melanie Wall, Katherine M Keyes, Magdalena Cerdá, John Schulenberg, Patrick M O'Malley, Sandro Galea, Rosalie Pacula, Tianshu Feng
Journal: The Lancet Psychiatry (2015)
Retinal Structure and Function in Achromatopsia
Authors: Venki Sundaram, Caroline Wilde, Jonathan Aboshiha, Jill Cowing, Colin Han, Christopher S. Langlo, Ravinder Chana, Alice E. Davidson, Panagiotis I. Sergouniotis, James W. Bainbridge, Robin R. Ali, Alfredo Dubra, Gary Rubin, Andrew R. Webster, Anthony T. Moore, Marko Nardini, Joseph Carroll, Michel Michaelides
Journal: Ophthalmology (2013)
Abstract 792: Reduced Myocardial S1P Signaling Post-MI: Novel Target for Molecular Intervention
Authors: Che-Chung Yeh, Susan Nicholas, Bo-qing Zhu, Richard Tu, John Cha, Michael Kelly, Donald A Vessey, Joel S Karliner, Michael J Mann
Journal: Circulation (2006)

Pathologic post-MI remodeling likely involves progressive apoptosis of cardiac myocytes (CM). Sphingosine 1 phosphate (S1P) has recently been identified as part of a critical signaling pathway with...
Inhibition of late asthmatic reaction in allergic asthma by the novel, selective PDE4 inhibitor Roflumilast*1
Authors: E.M. van Schalkwyk, H. Nell, K. van Heerden, L. Venter, S. Leichtl, D. Bredenbroeker, T.D. Bethke, W. Wurst, P.G. Bardin
Journal: Journal of Allergy and Clinical Immunology (2004)
Tracking and Functional Characterization of Epithelial–Mesenchymal Transition and Mesenchymal Tumor Cells during Prostate Cancer Metastasis
Authors: Marcus Ruscetti, Bill Quach, Eman L. Dadashian, David J. Mulholland, Hong Wu
Journal: Cancer Research (2015)

Abstract The epithelial–mesenchymal transition (EMT) has been postulated as a mechanism by which cancer cells acquire the invasive and stem-like traits necessary for distant metastasis. However, direct in vivo evidence for the role of EMT in the formation of cancer stem–like cells (CSC) and the metastatic cascade remains lacking. Here we report the first isolation and characterization of mesenchymal-like and EMT tumor cells, which harbor both epithelial and mesenchymal characteristics, in an autochthonous murine model of prostate cancer. By crossing the established Pb-Cre+/−;PtenL/L;KrasG12D/+ prostate cancer model with a vimentin-GFP reporter strain, generating CPKV mice, we were able to isolate epithelial, EMT, and mesenchymal-like cancer cells based on expression of vimentin and EpCAM. CPKV mice (but not mice with Pten deletion alone) exhibited expansion of cells with EMT (EpCAM+/Vim-GFP+) and mesenchymal-like (EpCAM−/Vim-GFP+) characteristics at the primary tumor site and in circulation. These EMT and mesenchymal-like tumor cells displayed enhanced stemness and invasive character compared with epithelial tumor cells. Moreover, they displayed an enriched tumor-initiating capacity and could regenerate epithelial glandular structures in vivo, indicative of epithelia–mesenchyme plasticity. Interestingly, while mesenchymal-like tumor cells could persist in circulation and survive in the lung following intravenous injection, only epithelial and EMT tumor cells could form macrometastases. Our work extends the evidence that mesenchymal and epithelial states in cancer cells contribute differentially to their capacities for tumor initiation and metastatic seeding, respectively, and that EMT tumor cells exist with plasticity that can contribute to multiple stages of the metastatic cascade. Cancer Res; 75(13); 2749–59. ©2015 AACR.
Beyond atopic eczema: filaggrin loss-of-function mutations in dry, fissured hand eczema
Authors: W. Uter
Journal: British Journal of Dermatology (2011)

Journal Article Beyond atopic eczema: filaggrin loss‐of‐function mutations in dry, fissured hand eczema Get access W. Uter W. Uter Department of Medical Informatics, Biometry and Epidemiology, University of Erlangen/Nürnberg, D‐91052 Erlangen, Germany E‐mail: wolfgang.uter@imbe.med.uni‐erlangen.de Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 166, Issue 1, 1 January 2012, Page 3, https://doi.org/10.1111/j.1365-2133.2011.10679.x Published: 01 January 2012
Abstract P318: Frequency of Fried Food Consumption Outside of Home and Risk of Nonfatal Myocardial Infarction in Costa Rica
Authors: Peter J Hu, Yanping Li, Hannia Campos
Journal: Circulation (2015)

Background:  Frequent consumption of fried food has been associated with risk of heart disease in some studies, but not others. One potential reason for the discrepant results is that most studies did not separate fried food consumed in and outside of home.   Objective:  To examine whether consumption of fried foods outside of home is associated with an increased risk of myocardial infarction (MI).   Design:  We conducted a population-based MI case-control study matched by age, sex, and residence in Costa Rica (n= 2,155 cases, 2,155 controls). Consumption of fried foods outside of home and other dietary habits were assessed by using a validated food frequency questionnaire.   Results:  The crude odds ratio (OR) of MI was 1.09 (95% confident interval (CI): 0.94-1.25), 1.62 (95%CI: 1.11-2.37) and 2.20 (95%CI: 1.59-3.04) for consuming fried foods outside of home 1-3 times/week, 4-6 times/week and daily, respectively, as compared to  0.3 for all tests, Figure 1). No significant association was observed between frequency of eating fried at home and risk of MI after multivariate adjustment. We estimated that increased intake of total energy and saturated fat and lower intake of fiber explained 42% (95% CI: 23%-62%) of the association between daily consumption of fried foods outside of home and risk of MI.   Conclusion:  Daily consumption of fried foods outside of home was significantly associated with an increased risk of MI, independent of cardiovascular risk factors. This association was partly explained by higher intake of total energy and saturated fat and lower intake of fiber.
Dermoscopy for melanoma: don't forget to take a photo
Authors: L. Thomas
Journal: British Journal of Dermatology (2015)

ORIGINAL ARTICLE, p 1269 After the first1 then, the more recent, second report on the MSLT1 trial2 it became clear that sentinel lymph node (SLN) biopsy in cutaneous melanoma cannot be considered as a therapeutic method despite the authors' conclusions.3 However, the histopathological status of the SLN has been clearly correlated with outcome and is, nowadays, considered to be a highly indicative prognostic indicator.4 5 SLN status in melanoma de facto creates new stage I–II and new stage III prognostic groups of patients with a survival rate at 5 years of approximately 91% and 41%, respectively. Better evaluation of the prognosis is part of the medical information that our patients deserve from us. This legitimates the fact that this procedure can be offered to selected patients with melanoma as a staging option after their informed consent. Moreover, relatively good prognosis of patients who have an SLN‐negative biopsy legitimates a nonaggressive follow‐up scheme mainly based on clinical examination as recommended in many international guidelines. In contrast, the high recurrence risk of patients who are SLN‐positive justifies the inclusion of these patients in adjuvant treatment clinical trials in the expectancy of, lastly, finding a significantly efficient treatment as well as more invasive (and irradiating) follow‐up policies with repeated imaging procedures. This latter option, recently reinforced by the favourable results of new therapeutic options offered in the case of visceral melanoma metastases, is probably, at least for immunotherapeutic options, more efficient in patients with good overall status.
Abstract 15161: Impact of Malnutrition Score Index on Short-term Clinical Outcome in Patients with Acute Decompensated Heart Failure
Authors: Naotsugu Iwakami, Toshiyuki Nagai, Yasuo Sugano, Takafumi Yamane, Tatsuhiro Shibata, Kenji Nakamura, Daigo Chinen, Yasuhide Asaumi, Takeshi Aiba, Teruo Noguchi, Kengo Kusano, Masaharu Ishihara, Hisao Ogawa, Satoshi Yasuda, Toshihisa Anzai
Journal: Circulation (2014)

Backgrounds: Recent studies have elucidated the association between malnutrition and poor long-term prognosis in patients with chronic heart failure (HF), using controlling nutritional status (CONUT) score, a simple and useful index for evaluating malnutrition. In this study, we aim to investigate the prognostic significance of CONUT score in patients with acute decompensated HF. Methods: We examined 320 consecutive patients in our prospective acute decompensated HF registry database from January 2013 to January 2014. Patients with acute coronary syndrome, in-hospital death, and without complete data-set at discharge were excluded. Finally, we selected 206 patients as a study population and malnutrition was defined as CONUT score above 3 at discharge. Results: 112 (54%) patients showed malnutrition at discharge. Patients with malnutrition had higher age, serum creatinine and plasma brain natriuretic peptide levels, and lower serum sodium level at discharge than those without. There were no significant differences between the groups in terms of sex, blood pressure, heart rate, left ventricular ejection fraction, etiology of HF and cardiovascular medications at discharge. During the median follow-up of 192 days (interquartile range = 109-260 days), malnutrition was associated with higher short-term adverse events including death and HF admission (P = 0.008, Figure). Cox proportional-hazards model analysis demonstrated that malnutrition was independently associated with adverse events (HR 2.00, 95% CI 1.01-4.17, P = 0.047), even after adjustment among variables including age (HR 1.04, 95% CI 1.00-1.08, P = 0.03) and serum sodium level (HR 0.93, 95% CI 0.88-1.00, P = 0.04). Conclusions: In patients with acute decompensated HF, malnutrition at discharge was independently associated with worse short-term clinical outcomes. These findings suggest that earlier intensive nutrition management might need to be considered.
Personal paper: The 1848 Public Health Act and its relevance to improving public health in England now
Authors: K. Calman
Journal: BMJ (1998)

Editorials by Alderslade, Palmer Recent advances p 584 Education and debate pp 587, 592

I keep copies of all major acts of parliament relevant to health and health care. I have consulted them from time to time over the past seven years. However, it is the 1848 public health act (An Act for Promoting Public Health) that I have looked at most regularly. Why does this act fascinate me, and why did I wish to see further reflection on its background and consequences? The answers lie in an understanding of the context of the act and its consequences. This is not because of the act's specific contents—though the regulations on slaughterhouses and the selling of meat are fascinating—but because of the general issues the act raises:

### Summary points

The 1848 act identified all the major public health issues of the time and established a structure for dealing with them

Public health became the responsibility of local people

Though health has improved immeasurably since 1848 some problems remain; the act's approach remains relevant today

The purpose of the act was to promote the public's health and to ensure “more effective provision … for improving sanitary conditions of towns and populace places in England and Wales.” Such clarity of purpose is impressive. The background to the act was a remarkable piece of work on mortality and morbidity rates across the country. The work established clear inequalities in health and recognised that some fundamental issues, such …
Site variation in EMS Treatment, Transport and Survival in relation to Restoration of Spontaneous Circulation (ROSC) for Adult Out-of-Hospital Cardiac Arrest: The Resuscitation Outcomes Consortium (ROC) Epistry
Authors: Mohamud R Daya, Kent M Koprowicz, Dana M Zive, Julie E Cummins, Gena K Sears, Terri A Schmidt, Shannon W Stephens, Ian G Stiell
Journal: Circulation (2007)
Cellular and Viral Antigens of BALB/c Myeloma 2
Authors: R. G. Krueger, W. H. Williams, G. C. Miller
Journal: JNCI Journal of the National Cancer Institute (1974)

As detected by immunofluorescent microscopy, BALB/c mice bearing a myeloma and BALB/c mice immunized with irradiated myeloma cells produced IgG against the tumor cells. The IgG reacted with the nucleus and cytoplasm of the 6 tumor lines examined but not with a syngenic tumor or BALB/c spleen cells. Three cell types were evident in all tumors: 1) a small cell, staining intensely and uniformly; 2) a large cell, constituting 3–5% of the total cells, that stained weakly; and 3) a cell of intermediate size, staining between the extremes of the small and large cell. IgG from rabbits immunized with gradient-purified myeloma A- and C-type particles gave intense staining with the cytoplasm and nucleus of the small cell, less intense uniform staining with the cytoplasm and particulate staining with the nucleus of the intermediate cell, and weak staining with the cytoplasm of the large cell. The viral antigens within or on the tumor cell stimulated humoral antibodies in tumor-bearing or immunized mice and contributed to the immune response against myeloma cells in tumor-bearing mice.
Antiphospholipid Antibodies and Risk for Recurrent Vascular Events—Reply
Authors: Steven R. Levine, Robin L. Brey, Barbara C. Tilley, Douglas A. Triplett, J. L. P. Thompson, Ralph L. Sacco, J. P. Mohr
Journal: JAMA (2004)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal