tbuckley/cabot-search huggingface dataset:
COPD and hypogonadism
Authors: Ivan Cekerevac, Marina Petrovic, Ljiljana Novkovic, Zeljko Mijailovic
Journal: European Respiratory Journal (2014)

Background: Many studies have shown that middle aged and elderly COPD patients may develop hypogonadism.

Objective :Assessment of potential risk factors for hypogonadism in COPD: airflow limitation, smoking, hypoxemia, systemic inflammation. To reveal associations of hypogonadism with severity of COPD, exercise tolerance and other systemic effects of COPD.

Methods: A group of 32 COPD men patients was analysed in the stable state of disease . Patients was divided into the four group according to BODE index. We used plasma concentrations of free testosterone (ELISA) to estimate hypogonadism and serum concentration of TNF-α, IL-6 (ELISA) and hsCRP to estimate systemic inflammation. BMI, MTCSA(midthigh muscle cross-sectional area) were done in order to assess nutrition status and state of skeletal muscles. Lumbar bone mineral density (BMD) were measured by DEXA.Exercise tolerance we measured by 6 minute walk distance (6MWD).

Results: Low value of free testosterone (<4.5 pg/ml) we found in 37.5% patients.Value of free testosterone and BODE index were the independent(χ2, p= 0.56).Also, we found statistical significant negative correlation between serum concentration of TNF-α and free testosterone (r=-0.422, p=0.04 ). Statistical significant corelation was beetwen serum concentration of free testosterone and BMI (r=0.414, p=0.044), MTCSA (r=0.497, p=0.016), BMD (r=0.456, p=0.02).Patients with lower values of free testosterone have significant exercise limitation acording to 6MWT: 268.33±32.35 vs. 334.25±43.24 m. (t test, p=0.02)

Conclusions: Systemic inflamation has potential role in development of hypogonadism in COPD. Hypogonadism may influence on other systemic effects of COPD and exercise tolerance, independently of severity of disease according to BODE index.
FEV1 dynamics and total NO3-/ NO2- level in exhaled breath condensate of current smokers
Authors: Elena Zaprudnova, Svetlana Soodaeva, Igor Klimanov, Timur Li, Natalia Popova, Nailya Kubysheva, Lidiya Nikitina, Fedor Petrovskiy
Journal: European Respiratory Journal (2014)

The study aim was to investigate pre- and post-exercise FEV1 level and the level of total NO3-/ NO2- in exhaled breath condensate (EBC) in smokers compared to non-smokers.

The control group included healthy non-smokers aged 18 - 35 years (those with no diagnosed respiratory diseases). The second group included current smokers aged 18 - 35 years (smoking history of ≥ 3 years) without respiratory pathology. Both groups were studied at rest, post-exercise FEV1 level was also measured after 10 minutes jogging.

The 1.6-fold reduced basal level of NO metabolites in EBC was found in smokers compared to non-smokers (1,42 ± 0,11 mkmol/l and 2,4 ± 0,26 mkmol/l respectively, p <0.05). Significant differences in post-exercise FEV1 level in smokers and non-smokers were not observed probably due to the small smoking history. Nevertheless, post-exercise FEV1 level in smokers was 1.3-fold lower than in non-smoking group.

Thus, in healthy smokers the reduced respiratory functional capacity was found to be associated with impaired NO synthesis in the lungs even at relatively small smoking history.
Blinatumomab: a bispecific T cell engager (BiTE) antibody against CD19/CD3 for refractory acute lymphoid leukemia
Authors: Jingjing Wu, Jiaping Fu, Mingzhi Zhang, Delong Liu
Journal: Journal of Hematology & Oncology (2015)

Targeted therapy has been the forefront of cancer treatment. Cancer immunotherapy is the most recent focus. In addition, novel immunotherapeutics targeting B cell receptor signaling (e.g., ibrutinib), T cell receptor ( e.g., CART19), and NK cells (e.g., AFM13) are being developed. This review summarized the new development in blinatumomab (MT103/MEDI-538), a first-in-class bispecific T engager (BiTE) antibody against CD19/CD3 in patients with relapsed/refractory precursor B cell acute lymphoid leukemia.
Nanoporous Metal–Phenolic Particles as Ultrasound Imaging Probes for Hydrogen Peroxide
Authors: Junling Guo, Xiaowei Wang, Darren C. Henstridge, Joseph J. Richardson, Jiwei Cui, Arpeeta Sharma, Mark A. Febbraio, Karlheinz Peter, Judy B. de Haan, Christoph E. Hagemeyer, Frank Caruso
Journal: Advanced Healthcare Materials (2015)

Nanoporous metal-phenolic particles are fabricated through the nanostructural replication of dense FeIII -TA complexes in nanoporous CaCO3 template particles. The particles have potential for the diagnostic detection of endogenous levels of H2 O2 ex vivo and in vivo by ultrasound imaging, which is based on the catalytic activity of the coordinated Fe3+ in the particles to break down H2 O2 to O2 microbubbles.
Urinary-derived Monocyte-Colony Stimulating Factor (P-100) following treatment with carboplatin and etoposide in small cell lung cancer (SCLC)
Authors: A. Jones, I.E. Smith, H.M. Earl, M.E.H.M. Van Hoef, J.A. Radford, P.J. Woll, N. Thatcher
Journal: Annals of Oncology (1993)
Non-invasive versus invasive heamodynamic evaluation in an heterogeneous pulmonary hypertension population: When echo goes in the cath-lab
Authors: Michele D'Alto, Emanuele Romeo, Paola Argiento, Anna Correra, Berardo Sarubbi, Maria Pignatiello, Antonietta Caronna, Nicola Grimaldi, Raffaele Calabrò, Maria Giovanna Russo
Journal: European Respiratory Journal (2012)

Aim: To evaluate the accuracy of doppler echocardiography (DE) in estimating the key measurements of right heart catheterization (RHC) in an heterogeneous pulmonary hypertension (PH) population: mean pulmonary artery pressure (mPAP), cardiac index (CI), capillary wedge pressure (CWP) and pulmonary vascular resistances (PVR).  Methods: One hundred thirty-five consecutive patients referred to our PH tertiary center from January to December 2011 underwent standard DE within 1 hour of a clinically indicated RHC.  Results: Twelve/135 (9%) did not have PH. Of 123 PH patients with PH, 54 (40%) had group 1, 39 (29%) group 2, 22 (16%) group 3, and 8 (6%) group 4 PH. Echo showed a satisfactory correlation to invasive evaluation.  Nevertheless, it was inaccurate in defining the presence of pre-capillary (CWP ≤15 mmHg, groups 1, 3 and 4) versus post-capillary (CWP >15 mmHg, group 2) PH leading to a misclassification in 22/123 (18%) of analyzed patients. In particular, sensitivity of echo for pre-capillary PH was 82% and specificity 83%.  Conclusion: Doppler echocardiography is an essential tool for the screening of PH, but it provides an initial approach to the patients with suspected PH. In particular, DE is frequently inaccurate in estimating the CWP leading to an hazardous misclassification of the PH.
Somatic mutations associated with leukemic progression of familial platelet disorder with predisposition to acute myeloid leukemia
Authors: I Antony-Debré, N Duployez, M Bucci, S Geffroy, J-B Micol, A Renneville, N Boissel, N Dhédin, D Réa, B Nelken, C Berthon, T Leblanc, M-J Mozziconacci, R Favier, P G Heller, O Abdel-Wahab, H Raslova, V Latger-Cannard, C Preudhomme
Journal: Leukemia (2015)
Normal 25-Hydroxyvitamin D Levels Are Associated with Less Proteinuria and Attenuate Renal Failure Progression in Children with CKD
Authors: Rukshana Shroff, Helen Aitkenhead, Nikola Costa, Antonella Trivelli, Mieczyslaw Litwin, Stefano Picca, Ali Anarat, Peter Sallay, Fatih Ozaltin, Aleksandra Zurowska, Augustina Jankauskiene, Giovanni Montini, Marina Charbit, Franz Schaefer, Elke Wühl
Journal: Journal of the American Society of Nephrology (2015)

Angiotensin-converting enzyme inhibitors (ACEi) for renin-angiotensin-aldosterone system (RAAS) blockade are routinely used to slow CKD progression. However, vitamin D may also promote renoprotection by suppressing renin transcription through cross-talk between RAAS and vitamin D-fibroblast growth factor-23 (FGF-23)-Klotho pathways. To determine whether vitamin D levels influence proteinuria and CKD progression in children, we performed a post hoc analysis of the Effect of Strict Blood Pressure Control and ACE Inhibition on Progression of CKD in Pediatric Patients (ESCAPE) cohort. In 167 children (median eGFR 51 ml/min per 1.73 m(2)), serum 25-hydroxyvitamin D (25(OH)D), FGF-23, and Klotho levels were measured at baseline and after a median 8 months on ACEi. Children with lower 25(OH)D levels had higher urinary protein/creatinine ratios at baseline (P=0.03) and at follow-up (P=0.006). Levels of 25(OH)D and serum vitamin D-binding protein were not associated, but 25(OH)D ≤50 nmol/L associated with higher diastolic BP (P=0.004). ACEi therapy also associated with increased Klotho levels (P<0.001). The annualized loss of eGFR was inversely associated with baseline 25(OH)D level (P<0.001, r=0.32). Five-year renal survival was 75% in patients with baseline 25(OH)D ≥50 nmol/L and 50% in those with lower 25(OH)D levels (P<0.001). This renoprotective effect remained significant but attenuated with ACEi therapy (P=0.05). Renal survival increased 8.2% per 10 nmol/L increase in 25(OH)D (P=0.03), independent of eGFR; proteinuria, BP, and FGF-23 levels; and underlying renal diagnosis. In children with CKD, 25(OH)D ≥50 nmol/L was associated with greater preservation of renal function. This effect was present but attenuated with concomitant ACEi therapy.
Risk Adapted-Postoperative Chemotherapy and Optimization of a Dose of Cranial Irradiation for Childhood Medulloblastoma
Authors: Toshiaki Ishida, Daiichiro Hasegawa, Tomoko Yanai, Keiichiro Kawasaki, Atsufumi Kawamura, Tatsuya Nagashima, Yoshinobu Akasaka, Toshinori Soejima, Makiko Yoshida, Yoshiyuki Kosaka
Journal: Annals of Oncology (2014)
Tumour necrosis factor-α blockers in the treatment of psoriasis
Authors: M. Lebwohl
Journal: British Journal of Dermatology (2010)

Journal Article Tumour necrosis factor‐α blockers in the treatment of psoriasis Get access M. Lebwohl M. Lebwohl The Mount Sinai Medical Center, New York, NY, U.S.A. E‐mail: Lebwohl@aol.com Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 162, Issue 6, 1 June 2010, Pages 1169–1171, https://doi.org/10.1111/j.1365-2133.2010.09835.x Published: 01 June 2010
MYC Disrupts the Circadian Clock and Metabolism in Cancer Cells
Authors: Brian J. Altman, Annie L. Hsieh, Arjun Sengupta, Saikumari Y. Krishnanaiah, Zachary E. Stine, Zandra E. Walton, Arvin M. Gouw, Anand Venkataraman, Bo Li, Pankuri Goraksha-Hicks, Sharon J. Diskin, David I. Bellovin, M. Celeste Simon, Jeffrey C. Rathmell, Mitchell A. Lazar, John M. Maris, Dean W. Felsher, John B. Hogenesch, Aalim M. Weljie, Chi V. Dang
Journal: Cell Metabolism (2015)
Pathogenic and Serologic Studies of Japanese Quail Infected With JM Strain of Marek's Disease Herpesvirus
Authors: T Mikami, M Onuma, T T Hayashi, M Narita, K Okada
Journal: JNCI Journal of the National Cancer Institute (1975)

Japanese quail were inoculated with Marek's disease herpesvirus at 1 day of age, and a second group of the same age was infected by contact with inoculated quail. A third group raised in our laboratory as a source of hatching eggs was accidentally infected with Marek's disease (MD). All quail were observed and examined for periods up to 360 days; the usual clinical signs of MD were not observed. However, the birds were susceptible to MD infection because of the evidence that: 1) The MD-specific agar gel-preceipitation (AGP) antigen was found in the feather tips or feather follicular epithelium of some of them; 2) the MD-specific AGP antibody was found in 6 of 57 exposed to MD; and 3) the virus was recovered from 4 MD-exposed birds by subpassage of their kidney cultures into quail embryo fibroblasts. The specificity of the AGP antigen or antibody in MD-infected quail was examined by the line of identity and cross-absorption tests. The antigen specificity was tested against similar to 700 sera from chickens and quail. Although most of these sera reacted with quail-positive antigen (QPA) prepared from MD-infected quail, some sera from infected or uninfected normal chickens reacted nonspecifically with QPA and with an antigen prepared from normal quail. By gel filtration on Sephadex G-150, the specific antigenic component could be separated from the nonspecific component(s) in QPA.
Increased Number of β-Adrenoceptors in Hepatocytes from Rats Treated with 2-Acetylaminofluorene
Authors: Magne Refsnes, Georg Sager, Dagny Sandnes, Tor-Erik Sand, Sten Jacobsen, Thoralf Christoffersen
Journal: Cancer Research (1986)

Abstract  Treatment of rats with chemical carcinogens, including 2-acetylaminofluorene (2-AAF), leads to a strong increase in the hepatic catecholamine-sensitive adenylate cyclase activity. The present study was undertaken to investigate the mechanism for the development of this increase. We report that hepatocytes isolated from rats which had been fed 2-AAF (0.025% w/w) for 8–12 weeks had an increased number of β-adrenoceptors, as determined by [3H]dihydroalprenolol binding to whole cells and [125I]iodocyanopindolol binding to washed particles. For both ligands the number of binding sites was about 4-fold higher in hepatocytes from 2-AAF-treated rats than in those from controls. The adenylate cyclase activity of the carcinogen-fed animals showed both a general increase manifested in the basal level (2-fold) and in the activities obtained by stimulation with guanine nucleotides (2-3-fold), cholera toxin (1.5-fold), and glucagon (1.3-fold) and a selective, larger increase in the β-adrenoceptor-linked activity (7-fold increment of the isoproterenol-sensitive activity). The results indicate that the number of hepatocyte β-adrenoceptors increases during 2-AAF carcinogenesis. This may, at least in part, explain the rise in catecholamine-sensitive adenylate cyclase activity.
Bone marrow transplantation prolongs survival after relapse in aggressive-lymphoma patients treated with the LNH-84 regimen.
Authors: A Bosly, B Coiffier, C Gisselbrecht, H Tilly, G Auzanneau, F Andrien, R Herbrecht, M Legros, Y Devaux, J Jaubert
Journal: Journal of Clinical Oncology (1992)

PURPOSE Of the 737 patients with aggressive lymphoma who were treated with the LNH-84 regimen, 244 with progressive disease after complete remission or partial response were analyzed retrospectively to determine the influence of intensive chemotherapy with bone marrow transplantation (BMT) on survival. PATIENTS AND METHODS Forty-four patients were treated with salvage chemotherapy, followed by autologous bone marrow transplantation (ABMT) in 40 and allogeneic BMT in four. The other 200 patients were treated with chemotherapy only. RESULTS Salvage treatment produced an objective response in 57% of the patients; 23% achieved a second complete remission. Median overall survival was longer for patients who were treated with ABMT than for those who were treated with chemotherapy only (12.4 v 6.7 months), as was median freedom from progression (FFP) survival (7.7 v 4 months). In multiparametric analysis, ABMT and normal initial lactic dehydrogenase (LDH) level were the primary parameters associated with longer survival. This is also true when (1) only patients younger than 60 years of age, (2) only patients who responded to salvage regimen, or (3) only patients with both conditions were included in the analysis. Patients who were not transplanted had a 1.69 to 2.26 relative risk of dying from their disease compared with those who were treated with intensive chemotherapy plus ABMT. CONCLUSION This study produced more evidence of the favorable impact of intensive chemotherapy with bone marrow rescue on survival in lymphoma patients who had relapsed.
Regulation of autophagy in amiodarone induced pulmonary fibrosis
Authors: Poornima Mahavadi, Clemens Ruppert, Ingrid Henneke, Lars Knudsen, Rachel Chambers, Mathias Ochs, Martina Korfei, Philipp Markart, Werner Seeger, Andreas Guenther
Journal: European Respiratory Journal (2013)

Rationale: Amiodarone (AD) is a well known anti arrhythmic drug, limited by its potential side effects. Severe pulmonary toxicity is reported in patients receiving amiodarone even at low doses, most common histological finding being chronic interstitial pneumonia. Amiodarone is known to induce autophagy in some cell types. A potential role for autophagy in the development of lung fibrosis has not been elucidated so far. Aims: We aimed to establish a murine model of amiodarone induced pulmonary fibrosis and assess the role of autophagy. Methods: AD or vehicle was instilled intra tracheally into C57BL/6 mice, and sacrificed on days 7, 14, 21 & 28. Lungs were either snap frozen or fixed in formalin. Fibrosis development was shown by hydroxyproline measurement. (MLE)-12 cells and AECII were treated with AD/vehicle and harvested after 8, 16 & 24 hours. Surfactant proteins and markers for autophagy, apoptosis and lysosomal stress were studied by western blotting, immunofluorescence and immunohistochemistry. Results: Lung fibrosis was observed in AD treated mice from day7. Accumulation of surfactant proteins was observed paralleled by an induction of autophagy (LC3B-II) lysosomal stress (Cathepsin D) and apoptosis (cleaved caspase 3) in AECII. MLE12 and AECII treated with AD showed the presence of LC3 positive vacuolar structures as after AD treatment. AD treated cells showed increase in the apoptotic marker cleaved caspase-3. Conclusion: We conclude that the autophagy pathway might be involved in the development of amiodarone inuced pulmonary fibrosis, but its interplay with apoptosis and lysosomal stress has yet to be revealed in this disease.
Face dermatitis from contaminants on a mask for anaesthesia
Authors: P. Komericki, C. Szolar-Platzer, B. Kränke, W. Aberer
Journal: British Journal of Dermatology (2000)

Allergic and irritant contact reactions to face masks for anaesthesia have rarely been reported. We present a 55‐year‐old female patient who developed facial allergic contact dermatitis after an operation requiring general anaesthesia. Patch tests showed positive reactions to cocospropylenediamin‐guanidinium‐diacetate (trivial name Dodigen 3558), a preservative used in disinfectants for medical instruments. It could be proven that residues of the causative allergen in the disinfectant adhered to the mask. This is the first report of a clinically relevant sensitization to this increasingly widely used agent.
Variable Symptomatology in Idiopathic Retroperitoneal Fibrosis
Authors: C D M Fletcher, P E M Jarrett
Journal: Journal of the Royal Society of Medicine (1983)

Idiopathic retroperitoneal fibrosis is uncommon enough to be placed low down on a list of differential diagnoses of any problem facing a general surgeon in a district hospital. In this paper, 4 cases of retroperitoneal fibrosis are described, all of whom presented within a 5-year period to the same surgeon; each described a different symptomatology. This paper serves to reiterate the diversity of presenting features in retroperitoneal fibrosis and to demonstrate that this condition may not be as rare as is widely believed.
Glucose Concentrations in Parotid Fluid and Venous Blood of Patients Attending a Diabetic Clinic<sup>1</sup>
Authors: L N Forbat, R E Collins, G K Maskell, P H Sönksen
Journal: Journal of the Royal Society of Medicine (1981)

Measurements of the glucose concentration in venous blood and parotid saliva taken from 31 diabetics attending a diabetic clinic showed values ranging respectively from 3.9 to 19.1 mmol/l and 0.06 to 0.83 mmol/l (means 9.6 mmol/l and 0.32 mmol/l respectively). Linear regression of salivary glucose on blood glucose gave a simple correlation coefficient of 0.18 (NS). Since salivary glucose levels did not reflect blood glucose levels, the possibility of diabetics regulating their metabolic control by the noninvasive technique of monitoring salivary glucose concentrations is not possible.
Reliving Rudhe syndrome: The reversible shunt related lobar emphysema- Report of cases and systematic review of literature
Authors: Maria Niña Banque, Ma. Dulce Requiron-Sy
Journal: European Respiratory Journal (2013)

Lobar emphysema (LE) is not quite uncommon in children with congenital heart diseases (CHD). In the year 2010, the name Rudhe syndrome was used to refer to reversible shunt related lobar emphysema, Rudhe proposed that the emphysema is secondary to the shunt thus surgical intervention be directed to the correction of the cardiac defect alone and not lobectomy.

We reviewed 4 cases of patients with concomitant LE and CHD. The medical records were evaluated with reference to age, type of CHD, pulmonary function, radiographic findings, pulmonary artery pressure, clinical signs and symptoms, surgical management and outcome after surgery. We also reviewed 21 literatures on LE with CHD.

Among the 4 cases we had, 3 were left to right shunts and 1 is a case of Tetralogy of Fallot (TOF) with an absent pulmonary valve. The 3 underwent correction of the cardiac lesion and repeat chest radiograph and CT scan showed almost complete resolution of the lobar emphysema with complete resolution of clinical symptoms 6months post cardiac surgery. The other one underwent TOF correction with lung tacking with radiographic resolution of the lobar emphysema however patient died of sepsis.

The literature review consisted of 137 subjects.The three most common cardiac lesions associated with lobar emphysema are ventricular septal defect, patent ductus arterioles and TOF with absent pulmonary valve. One hundred out of the 137 underwent correction of the cardiac lesion without lobectomy. Resolution of airway obstruction as well as radiographic resolution of the emphysematous lung were noted as early as 3months to 1 year post cardiac surgery.
Efficacy and safety of fluticasone/formoterol compared to fluticasone alone in patients with asthma
Authors: Tetyana Pertseva, Sanjeeva Dissanayake, Kirsten Kaiser
Journal: European Respiratory Journal (2012)

Background: To demonstrate efficacy and safety of fluticasone propionate/formoterol fumarate pMDI (FLUT/FORM) compared with fluticasone (FLUT) alone based on the change in FEV1 from morning pre-dose at baseline to 2 hours post-dose at week 12.  Methods: Patients included in the study were ≥12 years with symptomatic asthma for ≥1 year; steroid-requiring, had FEV1 40% to 80% [inclusive] of predicted normal values, and documented reversibility within 12 months of the study. Following a 2 week open-label run-in phase with FLUT (100 or 200 µg b.i.d.), 438 patients were randomised to treatment with FLUT/FORM (250/10 µg b.i.d.) or one of two pMDI formulations of FLUT alone (250 µg b.i.d.). The formulations were SkyePharma HFA pMDI (SKP) and GSK fluticasone pMDI (FLO), with n=146 in all groups. Albuterol/salmeterol was given as rescue medication.  Results: There was a clinically important and statistically significant difference in mean change from pre-dose FEV1 at baseline to 2 h post-dose at week 12 between the FLUT/FORM and both formulations of FLUT (SKP:LS mean difference=0.161 L,P  Conclusion: FLUT/FORM was superior to FLUT alone in the management of moderate to severe asthma in adolescents and adults. The overall safety profile of FLUT/FORM was consistent with that of FLUT.