tbuckley/cabot-search huggingface dataset:
Examination of TIMP-1 Levels and Relapse-Free Survival for Patients in NCIC CTG MA.14 Who Received Adjuvant Tamoxifen +/- Octreotide LAR.
Authors: S. Ali, J. Chapman, A. Lipton, K. Leitzel, K. Pritchard, X. Pu, C. Wilson, W. Carney, L. Shepherd, M. Pollak
Journal: Cancer Research (2009)

Abstract Background: Tissue inhibitor of metalloproteinase-1 (TIMP-1) has been shown to have diverse multifunctional roles in tumorigenesis. AL/KL/SA postulated from first line metastatic endocrine therapy that elevated pre-treatment serum TIMP-1 required additional therapy. NCIC CTG MA.14 adjuvant endocrine trial permitted examination of whether TIMP-1 serum levels post-chemotherapy was associated with RFS. Methods: NCIC CTG MA.14 is a trial where 667 postmenopausal patients were randomized to receive adjuvant tamoxifen +/- octreotide LAR with a stratification factor of no, concurrent or sequential chemotherapy. For the purposes of this work, this was simplified to whether a patient had or had not received adjuvant chemotherapy prior to the serum draw. Serum TIMP-1 was assessed on &amp;gt;90% of the trial patients. We examined the effect of baseline TIMP-1 levels on relapse-free survival (RFS) of 1) all types, 2) bone only, 3) all types of bone, and 4) non-bone, by timing of chemotherapy before the serum draw utilizing continuous TIMP (ng/ml) and categorical TIMP (&amp;lt;454, &amp;gt;454 ng/ml, based on 95% non-parametric cut-point for healthy post-menopausal females). Data were available on patient and tumour characteristics of age (years), pathologic tumour size (cm), pathologic lymph node status (# nodes), IGF-1, C-peptide, IGFBP-3. Step-wise forward Cox multivariate models were used where a factor was added if p&amp;lt;=0.05, and interaction terms were added for TIMP-1 level and timing of chemotherapy. Results: High (categorical) TIMP-1 was significantly associated with longer RFS (p=0.04) in the non-bone RFS multivariate model in the subgroup of patients who had prior chemotherapy, but not in those who did not. The interaction between TIMP-1 and administration of chemotherapy before serum draw was significant (p=0.02). High (continuous) TIMP-1 was significantly associated with longer bone only RFS (p=0.04) in subgroup who had no chemotherapy before the serum draw, but not in those who may or may not have had it after. There was no significant interaction effect. Categorical and continuous TIMP-1 were not associated with any other type of RFS. Conclusions: We found a predictive benefit with the assessment of serum TIMP-1 in hormone receptor positive patients, that high TIMP-1 levels after adjuvant chemotherapy were predictive of a reduction in non-bone RFS. Citation Information: Cancer Res 2009;69(24 Suppl):Abstract nr 3022.
Gliadin Does Not Induce Mucosal Inflammation or Basophil Activation in Patients With Nonceliac Gluten Sensitivity
Authors: Cristina Bucci, Fabiana Zingone, Ilaria Russo, Ivonne Morra, Raffaella Tortora, Norberto Pogna, Giulia Scalia, Paola Iovino, Carolina Ciacci
Journal: Clinical Gastroenterology and Hepatology (2013)
Family friendly care
Authors: Neil Marlow
Journal: BMJ (2004)

Kangaroo Mother Care (KMC) had a dramatic effect on the ability to provide care in its original setting and there is little doubt that it appears a safe and effective approach to caring for premature infants.1 Although the original aim was to provide effective care in settings with scarce resources, the use of KMC in Western settings would have different aims, which in essence reduce to three main areas: improved contact between mother and infant (and father and infant), quicker establishment of breast feeding, and shorter stay in hospital. Whether longer term outcomes in important measures, such as behaviour or developmental progress, are notably improved remains a tantalising possibility, but better early …
861 A COMPLEX IMMUNOREGULATORY DEFICIENCY CHARACTERISES TYPE 1 AUTOIMMUNE HEPATITIS
Authors: S. Ferri, M.S. Longhi, C. De Molo, A. Granito, G. Pappas, P. Muratori, L. Muratori, M. Lenzi, Y. Ma, G. Mieli-Vergani, F.B. Bianchi, D. Vergani
Journal: Journal of Hepatology (2008)
Specific Transplantation Tolerance
Authors: David H. Sachs
Journal: New England Journal of Medicine (1991)

IN 1945 Ray Owen reported a remarkable finding.1 He had examined the blood groups of freemartin cattle, which are fraternal twins born from a common placenta, and concluded that their blood groups could only be explained if hematopoietic cells had been exchanged between the sibling cattle in utero and if the progeny of these cells had persisted into adult life. The purpose of this study was to explain the unusual blood types of these cattle, but its implications for transplantation immunology are clear: Exposure of the immune system to foreign transplantation antigens during ontogeny is sufficient to permit the development . . .
The nature of transtubular Na and K transport in isolated rabbit renal collecting tubules
Authors: Jared J. Grantham, Maurice B. Burg, Jack Orloff
Journal: Journal of Clinical Investigation (1970)

In order to investigate the mechanism of Na and K transport, rabbit cortical collecting tubules were perfused in vitro and the concentrations of Na and K in lumen and bathing fluid and the transtubular electrical potential difference (PD) were measured. When the perfusate and external bath contained 150 Na-5 K (mEq liter(-1)), the sodium concentration decreased and the potassium concentration increased by an approximately equal amount in collected tubular fluid. The transtubular electrical potential was equal at both ends of the tubule in the steady state and ranged between 21 and 67 mv, lumen negative. In all tubules perfused at rates less than 0.5 nl min(-1), the K concentration of the collected fluid was higher and the Na concentration lower than that predicted for electrochemical equilibrium between lumen fluid and external bath, evidence for active transtubular transport of both cations. These results differ from those observed in rat distal tubule in which potassium secretion is passive. Active Na and K transport and the transtubular PD were decreased by (a) ouabain, (b) removal of sodium from the perfusate, or (c) removal of potassium from the external bath, evidence of interdependence of Na and K transport. The dependence of active K secretion on intraluminal Na concentration accounts for the phenomenon of "distal" Na-K exchange noted previously in clearance and stop-flow studies. The mechanism of Na transport may in part be electrogenic since the rate of decline of the transtubular PD in low K media was faster than could be accounted for on the basis of a reduction in cell potassium concentration.
Year of the Magicicada
Authors: Jason D. Eubanks
Journal: Annals of Internal Medicine (2013)

Ad Libitum4 June 2013Year of the MagicicadaJason D. Eubanks, MDJason D. Eubanks, MDFrom University Hospitals Case Medical Center, Cleveland, Ohio.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-158-11-201306040-00014 Audio Reading - “Year of the Magicicada” Audio. Michael A. LaCombe, MD, Annals Associate Editor, reads "Year of the Magicicada," by J.D. Eubanks. Your browser does not support the audio element. Audio player progress bar Step backward in current audio track Play current audio trackPause current audio track Step forward in current audio track Mute current audio trackUnmute current audio track 00:00/ SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail My fingers were smaller then,Innocent of the blood and deathThey now know so well,Fine, peach-flesh instrumentsThat reached with wonderFor the empty exoskeletonClinging to the bark of the weathered maple—A final molt and he is gone,A backyard litteredWith the empty armor of his comrades,But the air filled with a frenzied chorusOf winged imagoes.Of a single ... Author, Article, and Disclosure InformationAffiliations: From University Hospitals Case Medical Center, Cleveland, Ohio.Current Author Address: Jason D. Eubanks, MD; e-mail, [email protected]com. PreviousarticleNextarticle Advertisement Audio Reading - “Year of the Magicicada” Audio. Michael A. LaCombe, MD, Annals Associate Editor, reads "Year of the Magicicada," by J.D. Eubanks. Your browser does not support the audio element. Audio player progress bar Step backward in current audio track Play current audio trackPause current audio track Step forward in current audio track Mute current audio trackUnmute current audio track 00:00/ FiguresReferencesRelatedDetails Metrics 4 June 2013Volume 158, Issue 11Page: 848KeywordsBloodFallsFear ePublished: 4 June 2013 Issue Published: 4 June 2013 Copyright & PermissionsCopyright © 2013 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Effects of blockade of Kupffer cells by gadolinium chloride on hepatobiliary function in cold ischemia-reperfusion injury of rat liver
Authors: M Kukan, K Vajdova, J Horecky, A Nagyova, H M Mehendale, T Trnovec
Journal: Hepatology (1997)

The mechanisms of liver injury from cold storage and reperfusion are not completely understood. The aim of the present study was to investigate: 1) whether the inactivation of Kupffer cells (KCs) by gadolinium chloride (GadCl) modulates cold ischemia-reperfusion injury of rat liver; and 2) whether cold storage of rat liver involves injury to biliary epithelial cells (BECs). Hepatobiliary function was assessed using an isolated perfused rat liver model. Compared with control livers, in livers subjected to cold storage at 4 degrees C in Euro-Collins solution (EC) for 18 hours or in University of Wisconsin solution (UW) for 48 hours, portal flow was lower and resistance significantly higher, taurocholate (TC) and bromosulfophthalein (BSP) elimination were markedly impaired, bile flow was reduced, and lactate dehydrogenase (LDH) leakage into the perfusate was increased. Pretreatment of rats with GadCl, a selective KC toxicant, abrogated disturbances of the microcirculation in both models, but it did not influence viability and functional parameters of the liver. Most of the parameters studied in livers stored in UW solution for 18 hours were not significantly different from those found in control livers. As to biliary activity of gamma-glutamyl transferase (GGT), as an index of BEC integrity, it was increased with increasing time of cold storage. The reabsorption of glucose from the bile decreased with longer storage time. The results suggest the following: 1) that cold ischemia-reperfusion injury of rat liver is mediated by KC-dependent (hepatic microcirculation) and -independent (parenchymal cell function) mechanisms; and 2) that cold storage of rat liver induces functional impairment of BECs.
Surgeon's mistakes revive issue of regulation of European locums
Authors: C. Dyer
Journal: BMJ (2010)

A botched operation by a surgeon flown in from Germany to provide holiday cover at an English hospital has been blamed for hastening the death of a 94 year old woman.

Coroner Stuart Fisher said he had been “deeply shocked” by the case of Ena Dickinson, who died eight weeks after what should have been a routine hip operation but which left her bedbound.

The surgeon, Werner Kolb, who is based in Stuttgart but was on a six-week holiday cover placement, made a catalogue of errors during the hemiarthroplasty operation at Grantham Hospital in Lincolnshire in August …
Psoralen photochemotherapy of psoriasis
Authors: ELIZABETH HELL, C. HODGSON, V. MANNA
Journal: British Journal of Dermatology (2006)

The value of PUVA therapy in selected patients with severe psoriasis has been confirmed. Suppression of the disease was incomplete in those patients whose disease was unstable, with associated seborrhoeic dermatitic features. No consistent change in the proportion of epidermal cells in DNA synthesis could be demonstrated during regression of the psoriasis as a result of PUVA therapy.
Effect of Anti-inflammatory Drug Therapy on Clearance of 133Xe from Knee Joints of Patients with Rheumatoid Arthritis
Authors: C. Dick, P. H. Dick, G. Nuki, K. Whaley, J. A. Boyle, A. Shenkin, W. W. Downie, W. W. Buchanan
Journal: BMJ (1969)

The degree of joint inflammation in 13 patients with rheumatoid arthritis, as measured by clinical indices, was reduced by both sodium salicylate and indomethacin. The clearance rate of <sup>133</sup>Xe was reduced by indomethacin alone, and showed no correlation with the clinical features.
Monitoring Progress Toward US Preschool Immunization Goals
Authors: Felicity T. Cutts
Journal: JAMA (1992)

The United States has achieved over 97% immunization of children by school age and has reduced the incidence of vaccine-preventable diseases by more than 90% since the prevaccination era. However, children often do not receive immunizations at the recommended age, and in densely populated urban areas this delay in immunization has led to epidemics of measles. Correctable deficiencies of the immunization delivery system have been identified in these areas. To respond to needs, the public health infrastructure must be strengthened, and active participation from the private sector must be obtained, both in delivery of immunizations and in assessment of performance. Appropriate action must be stimulated by the provision of timely information on immunization coverage and on indicators of program performance at the local level. (<i>JAMA</i>. 1992;267:1952-1955)
CAUSATION OF PSORIATIC EPITHELIAL HYPERPROLIFERATION
Authors: Dvid Paslin
Journal: British Journal of Dermatology (1976)

Journal Article CAUSATION OF PSORIATIC EPITHELIAL HYPERPROLIFERATION Get access Dvid Paslin Dvid Paslin Serramonte Medical and Dental Center, 1500 Southgate Avenue, Daly City, California, U.S.A. Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 95, Issue 1, 1 July 1976, Page 106, https://doi.org/10.1111/j.1365-2133.1976.tb15543.x Published: 01 July 1976
Regulatory effect of nerve growth factor in α9β1 integrin–dependent progression of glioblastoma
Authors: Meghan C. Brown, Izabela Staniszewska, Philip Lazarovici, George P. Tuszynski, Luis Del Valle, Cezary Marcinkiewicz
Journal: Neuro-Oncology (2008)

In the present study we described the role of alpha9beta1 integrin in glioblastoma progression following its interaction with nerve growth factor (NGF). The level of expression of alpha9beta1 on astrocytomas is correlated with increased grade of this brain tumor and is highest on glioblastoma, whereas normal astrocytes do not express this integrin. Two glioblastoma cell lines, LN229 and LN18, that are alpha9beta1 integrin positive and negative, respectively, were used for alpha9beta1 integrin-dependent NGF-induced tumor progression. NGF was a significant promoter of promigratory and pro-proliferative activities of glioblastoma cells through direct interaction with alpha9beta1 integrin and activation of MAPK Erk1/2 pathway. The level of NGF increases approximately threefold in the most malignant glioma tissue when compared with normal brain. This increase is related to secretion of NGF by tumor cells. Specific inhibitors of alpha9beta1 integrin or gene silencing inhibited NGF-induced proliferation of LN229 cell line to the level shown by LN18 cells. VLO5 promoted alpha9beta1-dependent programmed cell death by induction of intrinsic apoptosis pathway in cancer cells. LN229 cells were rescued from proapoptotic effect of VLO5 by the presence of NGF. This disintegrin significantly inhibited tumor growth induced by implantation of LN229 cells to the chorioallantoic membrane (CAM) of quail embryonic model, and this inhibitory effect was significantly abolished by the presence of NGF. alpha9beta1 integrin appears to be an interesting target for blocking the progression of malignant gliomas, especially in light of the stimulatory effect of NGF on the development of these tumors and its ability to transfer proapoptotic signals in cancer cells.
Subungual melanoma in situ presenting as longitudinal melanonychia in a patient with familial dysplastic nevi
Authors: Paul Kechijian
Journal: Journal of the American Academy of Dermatology (1991)

Paul Kechijian, MD New York, New York Although the term dysplastic remains controversial,1 patients with large numbers of dysplastic nevi are at increased risk for developing malignant melanoma.2, 3 This article illustrates the importance of longitudinal melanonychia in a patient with many atypical nevi. It also presents the first account of subungual melanoma in situ in a patient with atypical nevi and a family history of melanoma.
Abstract 19697: Highly-Efficient in vivo Knock-Down of Ubiquitously Expressed eGFP in the Murine Heart with siRNA Delivered by a Pseudotyped AAV9 Vector
Authors: Bryan A Piras, Konkal-Matt R Prasad, Robert S Smith, Brent A French
Journal: Circulation (2010)

Introduction:  AAV9 is a potent gene delivery system that has been shown to preferentially transduce the heart over other tissues. We hypothesized that systemic administration of an AAV9 vector expressing siRNA against eGFP would inhibit gene expression in transgenic mice that express eGFP from the human ubiquitin C promoter (ubc-GFP).   Methods:  An AAV genome expressing siRNA against eGFP from the mouse U6 promoter was constructed and tested in vitro by cotransfecting it into 293 cells with a plasmid expressing eGFP. Microscopy, fluorimetric analysis using an Optima plate reader, real-time RT-PCR, and Western blotting were used to assess eGFP expression in vitro. The same AAV genome was cross-packaged into AAV9 capsids and injected intracardiac into 8-day old ubc-GFP mice in doses ranging from 10 10  to 10 11  vp/mouse (2-3 mice/group in 3 groups). Control ubc-GFP mice were injected with saline (n=2). Hearts were collected 4 wks after injection, frozen, sectioned and examined by microscopy. To compare eGFP expression, mean fluorescence intensity was measured with ImageJ in 16 distinct regions of interest per mouse heart (>1000 myocytes assessed per heart).   Results:  In vitro results (Panels A-B) indicated a 55% knock-down as assessed by real-time PCR (p   Conclusion:  AAV9 vectors expressing siRNA can be used to achieve cardiac-selective and highly-efficient knock-down of cardiac gene expression in vivo.
FUNCTIONAL IMPLICATIONS OF THE ATHLETE'S HEART: MYOCARDIAL STRAIN AND TWIST PROVIDE A MECHANISM FOR THE ADAPTS RESPONSE TO INTRAVASCULAR VOLUME CHALLENGE
Authors: Rory B. Weiner, Stephanie K. Isaacs, Francis Wang, Brant Berkstresser, Thomas Wang, Adolph Hutter, Gregory Lewis, Michael Picard, Aaron Baggish
Journal: Journal of the American College of Cardiology (2013)
Association of the Expression of Mutant Epidermal Growth Factor Receptor Protein as Determined with Mutation-Specific Antibodies in Non-small Cell Lung Cancer with Progression-Free Survival after Gefitinib Treatment
Authors: Koichi Azuma, Isamu Okamoto, Akihiko Kawahara, Tomoki Taira, Kazutaka Nakashima, Satoshi Hattori, Takashi Kinoshita, Masayuki Takeda, Kazuhiko Nakagawa, Shinzo Takamori, Michihiko Kuwano, Mayumi Ono, Masayoshi Kage
Journal: Journal of Thoracic Oncology (2011)
Intramuscular or Intralipomatous Injections?
Authors: W. Peter Cockshott, Gerard T. Thompson, Lois J. Howlett, Elizabeth T. Seeley
Journal: New England Journal of Medicine (1982)

VIEWING routine computerized-tomography (CT) scans of the pelvis suggests that in a North American population the majority of injections intended to be intramuscular are actually delivered into fat.To confirm or refute this impression we studied the thickness of gluteal fat in a hospital population. We found that few female patients and under 15 per cent of male patients do in fact receive an intramuscular injection when a needle of the usual size is inserted into the buttocks. The implications of this finding are discussed below.MethodsTo learn where the needle is introduced in intramuscular injections, we observed both . . .
Primary Therapy for Cushing's Disease With Metyrapone
Authors: Gabriel Dickstein
Journal: JAMA (1986)

A 13-year-old boy was diagnosed as suffering from pituitary-dependent Cushing's syndrome. He was treated with 2.0 g of metyrapone daily as the sole treatment for four years. All clinical and biochemical stigmata of Cushing's disease disappeared within a few months. The patient grew 23.0 cm in four years and regained normal health. No significant side effects of metyrapone were noticed. Administering the medication at 2 PM and 8 PM allowed higher cortisol levels in the morning and noon hours than in the evening and night, approximating the normal diurnal variation in cortisol production. We conclude that metyrapone may be considered the sole treatment in patients with Cushing's disease. (<i>JAMA</i>1986;255:1167-1169)
Type 1 Gastric Carcinoid: Is the Conservative Approach Always Indicated?
Authors: G. Baiocchi, M. Ronconi, V. Villanacci, M. Gambarotti, S. Giulini
Journal: Endoscopy (2004)

We read with interest the study by Ichikawa et al. published in the March 2003 issue of Endoscopy [1], focusing on the current indications for clinical management of type 1 gastric neuroendocrine tumors in the Rindi classification [2].
To Do No Harm: DES and the Dilemmas of Modern Medicine
Authors: Caroll Nadelson
Journal: JAMA (1985)

The authors of this book describe a modern medical tragedy, one that began with the same excitement that we experience in many medical discoveries. Diethylstilbestrol (DES) was prescribed between 1940 and 1970 to several million women to help them carry their pregnancies to term. The consequences of the use of this synthetic estrogen were not well known, and it was only later that they became clear. Drs Apfel and Fisher raise important questions about the explosion of modern medical technology. They vividly delineate the factors contributing to experimentation with new techniques and drugs and how the pressures experienced by physicians, coupled with their fantasies of heroism, meld with pressures from their patients to tempt them toake risks prematurely and totold to tto excitement of discovery and the promise of success. Diethylstilbestrol was first producedngland in 1938 and was originally recommended for toxemia in pregnant women. It was used to prevent
Clonality and clonal evolution of hepatocellular carcinoma with multiple nodules
Authors: Hey-Chi Hsu, Tzyy-Jen Chiou, Jen-Yang Chen, Chu-Shue Lee, Po-Huang Lee, Shian-Yang Peng
Journal: Hepatology (1991)

To determine the clonal evolution of hepatocellular carcinoma, the integrated hepatitis B virus DNA patterns of the main tumor, satellites and/or metastatic lesions were analyzed by Southern-blot hybridization in 28 hepatocellular carcinomas, including three HBsAg-seronegative cases. Unicentric or multicentric hepatocellular carcinoma was confirmed by histopathological criteria in 89% of the cases. Among 17 unicentric hepatocellular carcinomas, minor changes of the integration pattern--including partial loss or addition of the integration sites or both--were detected in the metastatic lesions in 29% of the cases. Furthermore, none of five cases with free-form hepatitis B virus DNA in the primary tumor had detectable free hepatitis B virus DNA in the metastatic lesions. These results suggest that the alteration of integrated hepatitis B virus DNA pattern during the course of tumor growth and metastasis may occur more often than previously perceived and that the switch-off of virus replication may be related to tumor metastatic potential. In eight cases with unilateral, multicentric hepatocellular carcinoma, two clones were detected in six cases, three were seen in another and four were seen in one. One case of note was a 9-yr-old boy with two histological types and two different integration patterns, one associated with vascular invasion and lung metastasis. Three patients with bilateral hepatocellular carcinoma were confirmed to have bicentric or tricentric hepatocellular carcinoma rather than intrahepatic dissemination and had survival rates similar to those in unicentric hepatocellular carcinoma. Three invasive HBsAg-seronegative hepatocellular carcinomas were found to have hepatitis B virus DNA integration and were of unicentric origin.(ABSTRACT TRUNCATED AT 250 WORDS)