tbuckley/cabot-search huggingface dataset:
Apoptin Nuclear Accumulation Is Modulated by a CRM1-Recognized Nuclear Export Signal that Is Active in Normal but not in Tumor Cells
Authors: Ivan K.H. Poon, Cristina Oro, Manisha M. Dias, Jingpu Zhang, David A. Jans
Journal: Cancer Research (2005)

Abstract Tumor cell–specific activity of chicken anemia virus viral protein 3 (VP3 or apoptin) is believed to be dependent on its ability to localize in the nucleus of transformed but not of primary or nontransformed cells. The present study characterizes the signals responsible for the novel nucleocytoplasmic trafficking properties of VP3 using two isogenic tumor/nontumor cell pairs. In addition to the tumor cell–specific nuclear targeting signal, comprising two stretches of basic amino acids in the VP3 COOH terminus which are highly efficient in tumor but not in normal cells, we define the CRM1-recognized nuclear export sequence (NES) within the VP3 tumor cell–specific nuclear targeting signal for the first time. Intriguingly, the NES (amino acids 97-105) is functional in normal but not in tumor cells through the action of the threonine 108 phosphorylation site adjacent to the NES which inhibits its action. In addition, we characterize a leucine-rich sequence (amino acids 33-46) that assists VP3 nuclear accumulation by functioning as a nuclear retention sequence, conferring association with promyelocytic leukemia nuclear bodies. This unique combination of signals is the basis of the tumor cell–specific nuclear targeting abilities of VP3.
Estrogen Replacement Therapy: New Options, Continuing Concerns-Reply
Authors: Karl Insogna
Journal: JAMA (1997)

In Reply.  —Dr Atkins interprets the findings of Cauley et al as evidence that HRT for the treatment of osteoporosis will increase the risk of breast cancer. This view differs from that of Cauley et al, who state that HRT may not increase the risk of breast  in women with osteoporosis who  had relatively low endogenous estrogen levels but may, instead, increase the risk for women with normal or high endogenous estrogen [who] take exogenous estrogen for other indications (eg, to prevent cardiovascular disease).  The posited relationship between BMD, HRT, and breast cancer risk is complex, as highlighted by the fact that African-American women have higher bone densities and a lower risk of breast cancer than white women, 1-3 indicating that factors other than, or in addition to, estrogen influence both breast cancer risk and bone density. In addition, as we noted in our Editorial, data on past HRT use
Reviewing screening mammograms with newly diagnosed patients is another unnecessary burden
Authors: A. Stotter, R. Windle, J. Jameson
Journal: BMJ (2001)

EDITOR—Paterson wrote about the unnecessary burden placed on patients with newly diagnosed cancer in discussing cancer registration.1 Patients are shocked at the diagnosis of cancer and have to work hard to get to grips with the news and its implications. When their participation is appropriate in treatment decisions—for example, in early stage breast cancer—they need to urgently understand the issues as treatment …
CARDIAC NUCLEAR MEDICINE AS A DECISION POINT
Authors: Richard F. Kiepfer, Barry M. Beller, Thomas W. Eades, Harold G. Felter, Burton Friedman, Max Gani, Reynaldo Sandoval
Journal: Clinical Nuclear Medicine (1982)

Kiepfer, Richard F. M.D.; Beller, Barry M. M.D.; Eades, Thomas W. M.D.; Felter, Harold G. M.D.; Friedman, Burton M.D.; Gani, Max M.D.; Sandoval, Reynaldo M.D. Author Information
Calcitonin gene-related peptide (CGRP) inhibits antigen-specific T-cell activation and subsequent development of a primary allergic immune response
Authors: A. Dakhama, A. Balhorn, C. Taube, A.G. Alvarez, T. Kodama, N. Miyahara, A. Joetham, K. Takeda, E.W. Gelfand
Journal: Journal of Allergy and Clinical Immunology (2003)
Forestalling a Filibuster — Senate Reform Bill Cleared for Floor Debate
Authors: John K. Iglehart
Journal: New England Journal of Medicine (2009)

Faced with unanimous Republican opposition, Senate Democrats, joined by two independents, closed ranks in a rare Saturday session on November 21 to advance consideration of a vast health care reform bill. Without a vote to spare on a motion to clear the way for floor consideration of the contentious bill, Democrats prevailed 60 to 39. Having defeated Republican efforts to derail the measure, Senate Majority Leader Harry Reid of Nevada can now open floor debate in early December.The bill would expand health insurance coverage to about 31 million people at a cost of $849 billion over 10 years, while . . .
Klinische Histopathologie der Leber: Ein Atlas
Authors: Jurgen Ludwig
Journal: JAMA (1968)

The authors, a pathologist and a clinician, have assembled this atlas from more than 38,000 liver biopsies at the Stadtkrankenhaus in Kassel, Germany. This book supplements the<i>Lehrbuch und Atlas der Laparoskopie und Leberpunktion</i>published by Kalk and Wildhirt in 1962. Most of the illustrations are of excellent technical quality and illustrate well a broad spectrum of histologic changes in hepatic diseases, such as the various types of hepatitis and cirrhosis, and the hepatic changes in diabetes, alcoholism, drug-induced cholestasis, extrahepatic bile-duct obstruction, and other conditions. The legends of the illustrations include some laboratory data and a brief morphologic description. Transaminase activities were not available for some of the earlier biopsies, but in these cases the Takata-Ara and other obsolete tests give some orientation. Laparoscopic findings are heavily relied on. To the American reader who has a good command of the German language (no English summaries), the clinical and morphologic
Bone Marrow Sarcoidosis
Authors: Peter M. Browne
Journal: JAMA (1978)

Five patients' bone marrow was involved with sarcoidosis, but their chest roentgenograms were normal. The diagnosis was substantiated by typical histological appearance of noncaseating granulomas in bone marrow, careful exclusion of infectious disease, and follow-up study for three to six years. Angiotensin-converting enzyme levels were elevated in all patients at the time of diagnosis. (<i>JAMA</i>240:2654-2655, 1978)
Cutaneous Manifestations of Infectious Mononucleosis
Authors: John T. McCarthy, Robert J. Hoagland
Journal: JAMA (1964)

CLINICIANS may be led to consider a diagnosis of infectious mononucleosis when presented with a patient with an acute febrile illness and a rash. Textbooks, especially older ones, frequently state that eruptions are frequent and the literature quotes an incidence of from 3% to 100% of patients. The purpose of this paper is to place the cutaneous and mucocutaneous manifestations of infectious mononucleosis in a perspective that will be of some practical clinical value. Dr. Hoagland has collected data on approximately 300 cases of carefully documented infectious mononucleosis and has previously presented diagnostic criteria.<sup>1-6</sup>All patients were personally questioned and examined by him and most were hospitalized. In essence, criteria for diagnosis consisted of a compatible clinical syndrome—fever, lymphadenopathy, and sore throat—plus supportive laboratory evidence —relative and absolute lymphocytosis persisting at least 10 days and properly interpreted serologic tests. The heterophile test must be significantly positive and must persist
Long noncoding RNA DANCR increases stemness features of hepatocellular carcinoma by derepression of CTNNB1
Authors: Sheng‐xian Yuan, Jie Wang, Fu Yang, Qi‐fei Tao, Jin Zhang, Li‐li Wang, Yuan Yang, Hui Liu, Zhen‐guang Wang, Qing‐guo Xu, Jia Fan, Lei Liu, Shu‐han Sun, Wei‐ping Zhou
Journal: Hepatology (2015)

Tumor cells with stemness (stem-cell) features contribute to initiation and progression of hepatocellular carcinoma (HCC), but involvement of long noncoding RNAs (lncRNAs) remains largely unclear. Genome-wide analyses were applied to identify tumor-associated lncRNA-DANCR. DANCR expression level and prognostic values of DANCR were assayed in two HCC cohorts (China and Korea, n = 135 and 223). Artificial modulation of DANCR (down- and overexpression) was done to explore the role of DANCR in tumorigenesis and colonization, and tumor-bearing mice were used to determine therapeutic effects. We found that lncRNA-DANCR is overexpressed in stem-like HCC cells, and this can serve as a prognostic biomarker for HCC patients. Experiments showed that DANCR markedly increased stemness features of HCC cells to promote tumorigenesis and intra-/extrahepatic tumor colonization. Conversely, DANCR knockdown attenuated the stem-cell properties and in vivo interference with DANCR action led to decreased tumor cell vitality, tumor shrinkage, and improved mouse survival. Additionally, we found that the role of DANCR relied largely on an association with, and regulation of, CTNNB1. Association of DANCR with CTNNB1 blocked the repressing effect of microRNA (miR)-214, miR-320a, and miR-199a on CTNNB1. This observation was confirmed in vivo, suggesting a novel mechanism of tumorigenesis involving lncRNAs, messenger RNAs, and microRNAs.These studies reveal a significance and mechanism of DANCR action in increasing stemness features and offer a potential prognostic marker and a therapeutic target for HCC.
Association between blood pressure and serum lipids in a population. The Tromsø Study.
Authors: K H Bønaa, D S Thelle
Journal: Circulation (1991)

BACKGROUND High blood pressure has been associated with elevated atherogenic blood lipid fractions, but epidemiological surveys often give inconsistent results across population subgroups. A better understanding of the relation between blood pressure and blood lipids may provide insight into the mechanism(s) whereby hypertension is associated with increased risk of coronary heart disease. METHODS AND RESULTS We assessed the cross-sectional relations of serum total cholesterol, high density lipoprotein (HDL) cholesterol, non-HDL cholesterol (total minus HDL cholesterol), and triglyceride levels with blood pressure in a population of 8,081 men 20-54 years old and 7,663 women 20-49 years old. Stratified analyses and multivariable methods were used to control for potential confounding anthropometric and lifestyle variables. Total and non-HDL cholesterol levels increased significantly with increasing systolic or diastolic blood pressure in both sexes. Men 20-29 years old had steeper regression slopes for blood pressure by total cholesterol level than did women of similar age. In men, the association between blood pressure and total cholesterol level decreased with age, whereas in women, it increased with age. Body mass index modified the relation, whereas smoking, physical activity, and alcohol consumption had little influence on the association. Triglyceride levels increased with blood pressure, but this relation was weak in lean subjects. HDL cholesterol level correlated positively with blood pressure in population subgroups having a high alcohol consumption. CONCLUSION These results support the hypothesis that there are biological interrelations between blood pressure and blood lipids that may influence the mechanisms whereby blood pressure is associated with risk of coronary heart disease.
A Systemic Approach to Containing Health Care Spending
Authors: Ezekiel Emanuel, Neera Tanden, Stuart Altman, Scott Armstrong, Donald Berwick, François de Brantes, Maura Calsyn, Michael Chernew, John Colmers, David Cutler, Tom Daschle, Paul Egerman, Bob Kocher, Arnold Milstein, Emily Oshima Lee, John D. Podesta, Uwe Reinhardt, Meredith Rosenthal, Joshua Sharfstein, Stephen Shortell, Andrew Stern, Peter R. Orszag, Topher Spiro
Journal: New England Journal of Medicine (2012)

2012In this election year, U.S. national spending on health care will reach $2.8 trillion, or about 18% of total spending on all goods and services.This high level of spending reduces our ability to invest in other important parts of the economy and also adds to our unsustainable national debt.There is wide agreement that we must find ways to bend the health care cost curve.Taking different approaches, the two articles that follow present a range of options, including reducing both the prices and quantity of services for public and private payers, reducing administrative costs, implementing new market-based incentives, and reforming the tax subsidy for employer-sponsored health insurance.It is our hope that these articles will stimulate discussion and debate on the best ways to address the cost problem and to place our health care system on a more sustainable path.
Variant esp gene as a marker of a distinct genetic lineage of vancomycinresistant Enterococcus faecium spreading in hospitals
Authors: Rob JL Willems, Wieger Homan, Janetta Top, Marga van Santen-Verheuvel, David Tribe, Xenia Manzioros, Carlo Gaillard, Christina MJE Vandenbroucke-Grauls, Ellen M Mascini, Eric van Kregten, Jan DA van Embden, Marc JM Bonten
Journal: The Lancet (2001)
A SLING TO PREVENT SAWING AND STRAIN ON THE NECK
Authors: H. W. Haight
Journal: JAMA (1930)

The accompanying illustration shows an ordinary triangular sling of brown sateen, two cut out of one square yard, with the cut edges hemmed, and a pad of the same material, 21 inches long and 4 inches wide, with a padding strip of cotton batting, 1 inch thick, of the same size, and with two straps 1¼ inches wide sewed across the anterior surface of the pad, 1¼ inches from each end. All loose edges are turned in and stitched. When used as illustrated, the sling prevents sawing and strain on the neck. The tailoring makes a neat appearance and the brown sateen blends well with any costume. In my experience, patients have been much more willing to wear the neat, comfortable, sightly sling. 5 Elm Row.
C5a decreases regional coronary blood flow and myocardial function in pigs: implications for a granulocyte mechanism.
Authors: S E Martin, D E Chenoweth, R L Engler, D M Roth, J C Longhurst
Journal: Circulation Research (1988)

Granulocytes cause some of the pathophysiological effects associated with the capillary no-reflow phenomenon during ischemia and in ischemia-reperfusion injury. However, no study has examined the consequences of in vivo granulocyte activation during normal perfusion pressures. In this study, we examined the effects of intracoronary administration of the complement component C5a, which is known to be a potent granulocyte activating factor. Nine open-chest, anesthetized pigs were instrumented to monitor regional coronary blood flow and segment shortening, left ventricular dP/dt, heart rate, and pulmonary artery and aortic blood pressures and to sample arterial and regional coronary venous blood for oxygen content and complete blood counts. Intracoronary infusion of human or porcine C5a in doses ranging from 10 to 500 ng produced a significant reduction in regional coronary blood flow and myocardial function. Although perfusion pressure and heart rate remained constant, venous oxygen content fell, indicating an imbalance between myocardial oxygen supply and demand. In addition, the arteriovenous difference of white blood cells was increased significantly after anaphylatoxin infusion, indicating intravascular trapping in the myocardium. Granulocytes accounted entirely for the differences in leukocyte counts because no significant changes in platelet, lymphocyte, or hematocrit levels were observed. Injection of vehicle alone did not alter any of the monitored variables.(ABSTRACT TRUNCATED AT 250 WORDS)
Guidelines for Interviewing
Authors: PHILIP L. HOOPER
Journal: Annals of Internal Medicine (1981)

Letters and Corrections1 August 1981Guidelines for InterviewingPHILIP L. HOOPER, M.D., ELIZABETH M. HOOPER, R.N., DONALD E. STEHR, M.D.PHILIP L. HOOPER, M.D.Search for more papers by this author, ELIZABETH M. HOOPER, R.N.Search for more papers by this author, DONALD E. STEHR, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-95-2-238_2 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: The provocative editorial by Platt (1) properly emphasizes the importance of the medical interview and the need for further research. As Platt points out, patients incessantly complain that physicians have bad manners, do not listen, and do no understand their human needs.Although the medical interview is a complex phychosocial event that warrants in-depth analysis, we have found several effective ground rules for interviewing that can be easily adopted by all medical providers, regardless of background or personality.1. Look at chart before you enter room.2. Introduction:A. Say the patient's name (don't use first name,...Reference1. PLATT F. Research in medical interviewing. Ann Intern Med. 1981;94:405-7. Editorial. LinkGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Veterans Administration Medical Center Albuquerque, NM 87108 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByBibliographyIndependent History-TakingJOHN C. MUELLER, M.D. 1 August 1981Volume 95, Issue 2Page: 238-238KeywordsChartsOutpatients Issue Published: 1 August 1981 PDF DownloadLoading ...
Effects of Chlorothiazide on Renal Hemodynamics
Authors: HERMAN VILLARREAL, ANDRÉS REVOLLO, JOSÉ EMILIO EXAIRE, FRANCISCO LARRONDO
Journal: Circulation (1962)

A comparative study was made of the acute effect of chlorothiazide upon renal hemodynamics in eight normotensive subjects and 10 patients with early essential hypertension. It was observed that blood pressure remained unchanged in normotensive subjects but was significantly reduced in hypertensive patients. Glomerular filtration rate was decreased similarly in both groups, whereas renal plasma flow was not modified in either. Osmotic clearance increased in all subjects, free water clearance diminished in normotensive (overhydrated) subjects, whereas in the hypertensive (not overhydrated) patients free water reabsorption increased. It is concluded that chlorothiazide reduces blood pressure in hypertensive patients but not in normotensive persons; that the kidney reacts in the same fashion in normotensive and hypertensive subjects under the action of the drug; and that the alterations in renal function observed with its use in hypertensive subjects are probably unrelated to changes in blood pressure.
Visualization of Ectopic Parathyroid Adenomas
Authors: Sandra Purz, Regine Kluge, Henryk Barthel, Frank Steinert, Patrick Stumpp, Thomas Kahn, Osama Sabri
Journal: New England Journal of Medicine (2013)

This case report of a woman with an ectopic parathyroid adenoma suggests that simultaneous positron-emission tomography (PET) and MRI might be superior to PET-CT for lesion localization.
Common polymorphisms in the complement system and susceptiblity to bacterial meningitis
Authors: Kirsten S. Adriani, Matthijs C. Brouwer, Madelijn Geldhoff, Frank Baas, Aeilko H. Zwinderman, B. Paul Morgan, Claire L. Harris, Arie van der Ende, Diederik van de Beek
Journal: Journal of Infection (2012)
Profound diathermy uhf in sport traumatological pathology
Authors: Suros Romagos Jordi, Suros Frigola Joaquim, Parrilla Forcada Iris
Journal: British Journal of Sports Medicine (2011)

Introduction Profound diathermy ultra high frequency (UHF), are electromagnetically waves which create a profound therapeutic thermal increase, at a muscle, tendon, or intra joint level depending pathology or therapeutically demand. Those are non-ion sated waves that through the therapeutic profoundness achieve to enter till 8–10 cm acting on the focal point of the lesion/injury. The deepness and these results can not be reached with any microwave or short wave.The working of the therapeutically frequency is 433.9 mHz with the potential of 150 w. Applicable in every acute inflammatory joint and chronicle dystrophy, fibrosis post surgical, tendinosis, condropathy, bursitis, hematomas, joint dislocation. With very high results from the first application through the profound thermal vasodilatation application in the tissue, creating a wide tissue oxygenation and stimulation of the segregation of collagen. This type of technology al by herself is very resolute and doesn’t have any side effects. You can take the benefit of the application of other therapies to potency the therapeutically effect. The application of the profound diathermy UHF, accelerates the recovery process, reduces the time of pain and reduces the rest time (of not paying sport), accelerating the reincorporation of the sport activity. Decrease the risk of consequences. The application of the therapy is 10 min it is possible to do it twice a day to accelerate the efficiency therapeutically, but then it would be enough to do it twice a week. The healing of the pathological described above last between 10 and 20 sessions.
The Location of Lymphatic Injury by the Use of Sky-Blue Dye
Authors: Jack Gurwitz
Journal: New England Journal of Medicine (1954)

IN 1950 Weinberg and Greaney1 first reported the identification of regional lymph nodes by the use of vital staining dye during operations for carcinoma. At that time they used pontamine sky blue in 2 per cent aqueous solution. Since then they have employed sky-blue dye,† 4 per cent solution, because of the rapidity with which the lymphatics and lymph nodes take up the dye.In the case described below a lymphatic leakage followed ligation and stripping of varicose veins. As in many cases the varicose veins were quite troublesome, producing lymphatic fluid and leakage for a long time. It was . . .
From actinic keratosis to squamous cell carcinoma
Authors: J-P. Ortonne
Journal: British Journal of Dermatology (2002)

Summary The development of actinic keratosis (AK) and squamous cell carcinoma (SCC) is the result of a complex sequence of events initiated by exposure to ultraviolet (UV) light. The application of sunscreens prior to sun exposure has been reported to reduce the incidence of AK. The initial damage takes place in the DNA and most of the UV‐induced lesions in the DNA are repaired. However, mutations may occur as a result of base mispairing of the cell and its DNA replicate before the DNA lesion is repaired. The genes involved in the repair process are also potential UV targets. Mutations in the tumour suppressor gene p53 are a common feature of AK and SCC. The hairless mouse is the best available animal model, in which lesions resembling human AK (papillomas), keratoacanthomas and SCCs may be induced. This model of multistage carcinogenesis offers an excellent tool for mechanistic studies. The relative efficacy of UV wavelengths (action spectrum) that induce SCC has been determined using the hairless mouse as a model. The action spectrum has been extrapolated to humans skin and is recognised worldwide.