Animal Experiments with Adrenal Cortical Extracts
Authors: J. L. Carr, C. L. Connor
Journal: Annals of Internal Medicine (1933)

Article1 March 1933Animal Experiments with Adrenal Cortical ExtractsJ. L. CARR, M.D., C. L. CONNOR, M.D.J. L. CARR, M.D.Search for more papers by this author, C. L. CONNOR, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-6-9-1225 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptSince the extraction of a potent principle from the adrenal cortex by Swingle and Pfiffner19and by Hartmann8much greater interest has centered upon this gland than ever before. Animal experimentation has at last acquired a tool to work with, and it is being used extensively. Great hopes have been entertained for the successful treatment of Addison's disease, and the cortical extract has been used for this purpose with some degree of success by Rowntree and others.16The very nature of this condition, however, would preclude the possibility of a cure, since it is caused in most cases by a...Bibliography1 CARR JL: Effects of ovaries in various stages of activity and of pregnancy upon adrenalectomized rats, Proc. Soc. Exper. Biol. and Med., 1931, xxix, 128-130. CrossrefGoogle Scholar2 CARR JL: Effect of Swingle's extract upon lactation in adrenalectomized white rat, Proc. Soc. Exper. Biol. and Med., 1931, xxix, 131. CrossrefGoogle Scholar3 CONNOR CL: The effect of suprarenal cortical substance on the ovaries of chickens and on chicken tumors, Arch. Path., 1930, ix, 1296. Google Scholar4 CONNOR CL: Effects of adrenal cortical extracts upon sex organs of animals, Proc. Soc. Exper. Biol. and Med., 1931, xxix, 131-134. 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Stimulation of the thymus gland following double suprarenalectomy in young rats, ibid., 1924, xl, 753-759. CrossrefGoogle Scholar10 LISSERSHEPARDSON HHC: Further and final report on case of tetania parathyreopriva, treated for year with parathyroid extract (Collip), with eventual death and autopsy, Endocrinology, 1929, xiii, 427-454. CrossrefGoogle Scholar11 MARINE D: The present status of the functions of the thyroid gland, Physiol. Rev., 1922, ii, 521-551. CrossrefGoogle Scholar12 MARINEMANLEYBAUMANN DOTEJ: The influence of thyroidectomy, gonadectomy, suprarenalectomy, and splenectomy on the thymus gland of rabbits, Jr. Exper. Med., 1924, xl, 429-443. CrossrefGoogle Scholar13 MÜLLER C: Der Einfluss der Hyperinterrenalisierung auf die Entwicklung der weiblichen Geschlechtsorgane, Endokrinologie, 1931, viii, 5-14. Google Scholar14 PALMER LJ: Is insulin reducing diabetic mortality? Conclusions from study of diabetic deaths in Washington in 1929, Northwest Med., 1931, xxx, 319-322. Google Scholar15 PENCHARZOLMSTEADGIRAGOSSINTZ RIJMG: Results of total and partial adrenalectomy and adrenal transplantation in the albino rat, Science, 1930, lxxii, 175-176. CrossrefGoogle Scholar16 ROWNTREE LG, and others: Treatment of Addison's disease with cortical hormone of suprarenal gland; summary of immediate results in twenty cases treated with preparation made by Swingle and Pfiffner, Jr. Am. Med. Assoc., 1931, xcvii, 1446-1453. CrossrefGoogle Scholar17 SCOTTBRADFORD WJWL: Effect of adrenal cortex upon thymic weight and resistance to bacterial intoxication in chronic adrenal insufficiency, Proc. Soc. Exper. Biol. and Med., 1931, xxviii, 428-431. CrossrefGoogle Scholar18 STEWARTROGOFF GNJM: Studies on adrenal insufficiency; influence of pregnancy upon survival period in adrenalectomized dogs, Am. Jr. Physiol., 1927, lxxix, 508-535. Google Scholar19 SWINGLEPFIFFNER WWJJ: Studies on adrenal cortex; effect of lipid fraction upon life-span of adrenalectomized cats, Am. Jr. Physiol., 1931, xcvi, 153-163.—Studies on adrenal cortex; aqueous extract of adrenal cortex which maintains life of bilaterally adrenalectomized cats, ibid., xcvi, 164-179. CrossrefGoogle Scholar20 BRITTON SW: Adrenal insufficiency and related considerations, Physiol. Rev., 1930, x, 629-630. (Quotation from VINCENT, S.: Internal secretion and the ductless glands, 1924, Edward Arnold & Co., London). Google Scholar21 WARTHIN AS: Constitutional entity of exophthalmic goiter and so-called toxic adenoma, ANN. INT. MED., 1928, ii, 553-570. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: San Francisco, California*Read before the American College of Physicians, April 7, 1932, at San Francisco, California.†From the Department of Pathology, University of California Medical School. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byDie NebenniereZur Antithyreoiden Wirkung der Nebennierenrinde 1 March 1933Volume 6, Issue 9Page: 1225-1230KeywordsAdrenal cortex ePublished: 1 December 2008 Issue Published: 1 March 1933 PDF downloadLoading ...