CIRCULATORY STUDIES ON ANOXEMIA IN MAN WITH RESPECT TO POSTURE AND CARBON DIOXIDE
Authors: E. Gellhorn
Journal: Annals of Internal Medicine (1937)

Article1 March 1937CIRCULATORY STUDIES ON ANOXEMIA IN MAN WITH RESPECT TO POSTURE AND CARBON DIOXIDEE. GELLHORN, M.D., PH.D.E. GELLHORN, M.D., PH.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-10-9-1267 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptMosso,22Margaria,20Childs, Hamlin and Henderson4noted that the effects of anoxemia can be alleviated by breathing low concentrations of CO2. In several studies (Gellhorn7, 8) we have confirmed and extended these observations on a quantitative basis. It was shown in particular that the effects of anoxemia on various processes occurring in the human central nervous system can be offset by inhaling 3 per cent CO2during the period of anoxemia. This effect was thought to be due mainly to circulatory and respiratory adjustments. This idea is supported by the fact that under the influence of CO2the circulation through...Bibliography1. ALVAREZROTH WCG: Orthostatic hypotension: report of a case with some unusual features, Proc. Staff Meet. Mayo Clinic, 1935, x, 483-489. Google Scholar2. BARCROFT J: The respiratory function of the blood. I. Lessons from high altitudes, Cambridge, 1925. Google Scholar3. BARCROFT J: The respiratory function of the blood. II. Hemoglobin, Cambridge, 1928. Google Scholar4. CHILDSHAMLINHENDERSON SBHY: Possible value of inhalation of carbon dioxide in climbing great altitudes, Nature, 1935, cxxxv, 457. CrossrefGoogle Scholar5. CHRISTENSENKROGH EHA: Fliegeruntersuchungen; 2 Mitteilung: Die Wirkung niediger O2-Spannung auf Höhenflieger, Skandin. Arch. Physiol., 1936, lxxiii, 145-154. CrossrefGoogle Scholar6. COBBFREMONT-SMITH SF: The cerebral circulation. XVI. Changes in the human retinal circulation and in the pressure of the cerebrospinal fluid during inhalation of a mixture of carbon dioxide and oxygen, Arch. Neur. and Psych., 1931, xxvi, 731-736. CrossrefGoogle Scholar7. GELLHORN E: Value of carbon dioxide in counteracting oxygen lack, Nature, 1936, cxxxvii, 700. CrossrefGoogle Scholar8. GELLHORN E: The effectiveness of carbon dioxide in combating the changes in visual intensity discrimination produced by oxygen deficiency, Am. Jr. Physiol., 1936, cxvii, 75-78. CrossrefGoogle Scholar9. GELLHORNSPIESMAN EIG: The influence of hyperpnea and variations of O2- and CO2-tension in the inspired air upon hearing, Am. Jr. Physiol., 1935, cxii, 519-528. CrossrefGoogle Scholar10. GELLHORNSPIESMAN EIG: The influence of hyperpnea and of variations of the O2- and CO2-tension in the inspired air upon after-images, Am. Jr. Physiol., 1935, cxii, 620-626. CrossrefGoogle Scholar11. GELLHORNLAMBERT EEH: Unpublished observations. Google Scholar12. GIBBSGIBBSLENNOX FAELWG: Changes in human cerebral blood flow consequent on alterations in blood gases, Am. Jr. Physiol., 1935, cxi, 557-563. CrossrefGoogle Scholar13. HENDERSON Y: Acapnia and shock. II. A principle underlying the normal variations in the volume of the blood stream, and the deviation from this principle in shock, Am. Jr. Physiol., 1909, xxiii, 345-373. CrossrefGoogle Scholar14. HENDERSONOUGHTERSONGREENBERGSEARLE YAWLACF: Muscle tonus, intramuscular pressure and the venopressor mechanism, Am. Jr. Physiol., 1936, cxiv, 261-268. Google Scholar15. HERBSTMANIGOLD RK: Das Verhalten von Kreislauf und Atmung bei Sauerstoffmangel, Arbeitsphysiol., 1936, ix, 166-181. Google Scholar16. HERING HE: Die Karotissinusreflexe auf Herz und Gefässe, Dresden and Leipzig, 1927. Google Scholar17. HEYMANSBOUCKAERTREGNIERS CJJP: Le sinus carotidien, 1933, G. Doin and Cie, Paris. Google Scholar18. KOCH E: Reflektorische Selbststeuerung des Kreislaufes, Dresden and Leipzig, 1931. Google Scholar19. LENNOXGIBBS WGEL: Blood flow in brain and leg of man, and changes induced by alteration of blood gases, Jr. Clin. Invest., 1932, xi, 1155-1177. CrossrefGoogle Scholar20. MARGARIA R: La resistenza degli animali alla depressione barometrica con varie miscele di ossigens e di anidride carbonica, Arch. di Sci. Biol., 1928, xi, 425-452. Google Scholar21. MATEEFFSCHWARZ DW: Der orthostatische Kreislaufskollaps—Gravitationsshock—bei vermindertem Luftdruck, Pflüger's Arch., 1935, ccxxxvi, 77-92. CrossrefGoogle Scholar22. MOSSO A: Life of man on the high Alps, London, 1898. Google Scholar23. RAAB W: Die Beziehungen zwischen CO2-Spannung und Blutdruck bei Normalen und Hypertonikern, Ztschr. f. exper. Med., 1929, lxviii, 337-370. CrossrefGoogle Scholar24. SCHMIDT CF: The intrinsic regulation of the circulation in the parietal cortex of the cat, Am. Jr. Physiol., 1936, cxiv, 572-585. CrossrefGoogle Scholar25. SMITHMOERSCH HLFP: Further study on the hypersensitive carotid sinus reflex syndrome, Proc. Staff Meet. Mayo Clinic, 1936, xi, 380-383. Google Scholar26. STARLING EH: Principles of human physiology, 5 ed., 1930, Philadelphia, p. 809. Google Scholar27. TALENTI C: Sulla composizione dell'aria alveolare negli individui sottoposti a depressione barometrica en aria ed in varie miscele gassose e sulla resistenza massima dell'uomo alla depressione, Arch. di Sci. Biol., 1930, xiv, 125-156. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Chicago, Illinois*Received for publication November 30, 1936.From the Department of Physiology, College of Medicine, University of Illinois. Nextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byDas Verhalten der menschlichen Handvenen bei akuter arterieller HypoxieFAINTING AND CEREBRAL DAMAGEÜber akute HypoxieDie Wirkung des Höhenklimas und die Akklimatisierungsprozesse in großer Höhe 1 March 1937Volume 10, Issue 9Page: 1267-1278KeywordsAttentionBreathingCarbon dioxideCentral nervous systemHypoxiaInhalationPostural control ePublished: 1 December 2008 Issue Published: 1 March 1937 Copyright & PermissionsCopyright, 1937, by The American College of PhysiciansPDF downloadLoading ...