tbuckley/cabot-search huggingface dataset:
Differential effects of red and white wines on inhibition of the platelet-derived growth factor receptor: impact of the mash fermentation
Authors: J. Sparwel, M. Vantler, E. Caglayan, K. Kappert, J. W.U. Fries, H. Dietrich, M. Bohm, E. Erdmann, S. Rosenkranz
Journal: Cardiovascular Research (2008)

Moderate wine consumption is associated with a significant reduction of cardiovascular mortality. The molecular basis of this phenomenon remains unknown. Platelet-derived growth factor (PDGF) is an important contributor to atherogenesis. We investigated the effects of selected red and white wines on PDGF receptor (PDGFR) signalling in rat and human vascular smooth muscle cells (VSMCs). All red wines concentration dependently inhibited the ligand-induced tyrosine phosphorylation of the PDGFR, downstream signalling events such as mitogen activated protein (MAP) kinase activation (Erk 1/2) and induction of immediate early genes (Egr-1, c-fos), and PDGF-induced cellular responses, whereas all white wines had no effect. At concentrations achieved after wine consumption in humans, all red wines completely abolished PDGF-dependent VSMC proliferation and migration. Red wines also inhibited PDGFR phosphorylation in vascular tissue, and in human coronary smooth muscle cells. Quantitative analyses of all tested wines and of samples collected at various time points (Days 0–16) of the 'mash fermentation', which is only performed for red wine, revealed that flavonoids of the catechin family, which potently inhibit PDGFR signalling, are extracted from grape seeds and skins during this process and therefore accumulate specifically in red wine. The accumulation of flavonoids correlated with the inhibitory potency of red wines on PDGFR signalling. Furthermore, this procedure could be imitated by incubation of wines with shredded grape seeds, and flavonoid-enriched white wine inhibited the PDGFR as potently as red wines. Only red wines abrogate a critical pathogenic mechanism during atherogenesis, PDGFR signalling, in VSMCs. This effect is mediated by non-alcoholic constituents, which accumulate during the mash fermentation. Our findings offer a molecular explanation for the vasoprotective effects particularly of red wine. Therefore, future epidemiological studies should consider differential protective effects of red and white wine in vivo.
THE REVERSE SELECTIVE BACTERIOSTATIC ACTION OF ACID FUCHSIN
Authors: Victor Burke, Charles E. Skinner
Journal: The Journal of Experimental Medicine (1924)

1. The reverse selective action attributed to acid fuchsin can be explained on the basis of spore resistance. This action does not apply to the vegetative cells of Gram-positive spore bearers. It cannot be extended to include the Gram-negative spore bearers. 2. The selective action of acid fuchsin is that of an ordinary weak disinfectant and is not comparable to the selective action of the triphenylmethane dyes. 3. A lack of parallelism between the bactericidal and bacteriostatic action of acid fuchsin can be explained on the basis of spore resistance and it does not exist when spores are excluded. 4. Acid fuchsin is a weaker disinfectant than basic fuchsin for both Gram-negative and Gram-positive bacteria. The process of sulfonation by which acid fuchsin is made from basic fuchsin results in a reduction in the bactericidal action of the dye for Gram-negative and Gram-positive bacteria. 5. The most significant fact in the action of the dyes on bacteria is the toxic effect of the triphenylmethane dyes on Gram-positive spore-bearing organisms.
Raving and Melancholy Madness
Authors: M. Ellul
Journal: BMJ (2012)

These well known but grotesque figures supposedly represent the two faces of mental illness. One is reposed and quiet but vacant and disengaged; the other is full of anguish and writhing against the chains used to bind psychotic patients before the days of the chemical cosh. Raving and Melancholy Madness , sculpted by Caius Gabriel Cibber (1630-1700), stood above the entrance to the old Bethlem Hospital from 1676 until 1815 at its site in Moorfields, London. The representations are life sized and were designed to recline over a portico and look down on visitors and staff coming in and out.

What possessed the sculptor to carve these caricatures to guard the entrance to Bedlam? Perhaps they were warning of what can happen when …
Permanent Pervenous Atrial Synchronized Ventricular Pacing
Authors: ARTHUR J. MOSS, ROBERT J. RIVERS, DAVID H. KRAMER, SETH RESNICOFF
Journal: Circulation (1973)

Permanent pervenous atrial synchronized ventricular pacing was successfully accomplished in three patients. Atrial sensing was obtained from an electrode positioned in the coronary vein. Atrial electrograms with P waves greater than 1.5 mv were present in all three cases. Ventricular stimulation was accomplished through a separate electrode placed in the right ventricular apex. The left cephalic vein admitted both catheters, and the two electrodes were connected to an implantable P wave synchronized unit. The beneficial hemodynamic effects of atrial synchronized ventricular pacing were clinically evident. This new pervenous technique provides an optimal method of synchronized pacing in patients with heart block, intact sinoatrial activity and significantly compromised cardiac function.
COMPARISON OF ABILITY STRESS TESTS TO ACCURATELY PREDICT SPECIFIC AREAS OF ISCHEMIA
Authors: Anitha Rajamanickam, Samir Kapadia, Thadeo Catacutan, Alraies Chadi, Ankita Satra, Amit Maranganti, Marwan Nasif, Anuradha Ramaswamy, Sam Butler, Stephen Ellis, Manuel Cerqueira, James B. Young
Journal: Journal of the American College of Cardiology (2010)
Beware of being captured by an analogy: Dreams are like many things
Authors: Matthew Hugh Erdelyi
Journal: Behavioral and Brain Sciences (2013)

Abstract Classic traditions have linked dreams to memory (e.g., “dreaming is another kind of remembering” [Freud 1918/1955]) and modern notions like implicit memory subsume dreaming by definition. Llewellyn develops the more specific thesis that rapid eye movement (REM) dreams, because of their similarities to mnemonic techniques, have the function of elaboratively encoding episodic memories. This proposal is premature, requiring exigent testing. Other analogs of dreams, for example, jokes, do not invoke function but do contribute to dream science.
Platelet-release reaction in myocardial infarction.
Authors: S Heptinstall, G P Mulley, P M Taylor, J R Mitchell
Journal: BMJ (1980)

A study was made of the platelet-release reaction in heparinised platelet-rich plasma taken from 26 patients, of whom 22 had sustained a definite and four a possible myocardial infarction, and from 54 age-matched controls. No significant differences in reaction were observed between the two groups. Signficant differences were seen, however, between eight patients who died within a year after infarction and the controls (P less than 0.01) and the remaining 18 patients who survived (P = 0.02). These differences were abolished when sodium citrate was included in the experimental procedure. Poor prognosis was thus related to an increased platelet-release reaction after infarction.
Professional Integrity in Clinical Research
Authors: Franklin G. Miller
Journal: JAMA (1998)

In response to public concern over abuses in human medical experimentation, the dominant approach to the ethics of clinical research during the past 30 years has been regulation, particularly via institutional review board review and approval of scientific protocols and written consent forms. However, the effectiveness of regulatory mechanisms in ensuring the ethical conduct of clinical research is limited. Little attention has been devoted to the nature and role of professional integrity of physician investigators, a conscientious framework for guiding investigators in the socially important but morally complex activity of clinical research. Professional integrity is vital in forging an ethically sound relationship between investigators and patient volunteers, a relationship that differs in important ways from the patient-physician relationship in standard clinical practice. We examine critically 2 models of the moral identity of physician investigators, the investigator as clinician and the investigator as scientist; in neither of these 2 models can the physician investigator eliminate completely the moral conflicts posed by clinical research. The professional integrity of physician investigators depends on a coherent moral identity that is proper to the enterprise of clinical research. The roles of clinician and scientist must be integrated to manage conscientiously the ethical complexity, ambiguity, and tensions between the potentially competing loyalties of science and care of volunteer patients.
Reference values of interrupter respiratory resistance in healthy preschool white children
Authors: E Lombardi
Journal: Thorax (2001)

Interrupter respiratory resistance (Rint) is reported to be useful in evaluating lung function in poorly collaborating patients. However, no reference values are available from large samples of preschool children using the standard interrupter method. The aim of this study was to define reference Rint values in a population of healthy preschool children.Rint was assessed without supporting the cheeks in children with no history of wheeze from six kindergartens. To evaluate the effects of upper airway compliance on Rint in healthy children, an additional group of preschool children with either no history of wheeze or no respiratory symptoms at the time of testing underwent Rint measurements in our lung function laboratory with and without supporting the cheeks. Short term (about 1 minute apart) and long term (mean 2.5 months apart) repeatability of Rint measurements (2 SDs of the mean paired difference between measurements) was also assessed in children referred for cough or wheeze.A total of 284 healthy white children (age range 3.0-6.4 years) were evaluated. Mean inspiratory and expiratory Rint (RintI and RintE) did not differ significantly in boys and girls. Age, height, and weight showed a significant inverse correlation with both RintI and RintE in the univariate analysis with linear regression. Multiple regression with age, height, and weight as the independent variables showed that all three variables were significantly and independently correlated with RintI, whereas only height was significantly and independently correlated with RintE. Supporting the cheeks had no significant effect on RintI (n=29, median 0.673 v 0.660 kPa/l.s, p=0.098) or RintE (n=39, median 0.702 v 0.713 kPa/l.s, p=0.126). Short term repeatability was 0.202 kPa/l.s for RintI (n=50) and 0.242 kPa/l.s for RintE (n=69). Long term repeatability was 0.208 kPa/l.s for RintE (n=26).We have reported reference Rint values in preschool white children and have demonstrated the usefulness of this technique in assessing lung function in this age group.
Marihuana and Automobile Driving
Authors: Joseph H. Davis
Journal: JAMA (1972)

To the Editor.—  The report in INTERNATIONAL COMMENTS (220:139, 1972) pertaining to the adverse influence of marihuana on driving exemplifies a problem which has been minimized in the discussions over legalization of the drug. In the above report, emanating from West Germany, test subjects had marked deterioration in driving ability after having smoked marihuana. This lends credence to the report previously published, 1 wherein college students familiar with the effects of driving under the influence of marihuana were queried as to their attitudes. The majority of former users felt that their performances were downgraded in regard to speed estimation, distance perception, ability to keep the vehicle under control, and ability to respond to emergency situations. These observations were corroborated from the tape-recorded observations of two drivers who elected to drive upon an expressway while under the influence of the drug. 2 In one of these instances, the driver was forced
The metabolic activity of primary cultures of guineapig dorsal skin cells
Authors: C. PROTTEY, T. F. M. FERGUSON
Journal: British Journal of Dermatology (1974)

Freshly harvested epidermal cells from the dorsal skin of albino guinea‐pigs have been cultured for several days on glass slides and on collagen films within Leighton tubes. Routinely it has been observed that the keratinocytes which initially attach to the substratum rapidly detach again during the first 6 days and the presence of collagen does not influence their overall survival. However, the keratinocytes cultured on collagen films exhibit greatly enhanced cellular metabolism, in particular, dehydrogenase activity, DNA synthesis and phospholipid turnover. These findings support those published by others that collagen (and, presumably, other components of dermis) greatly influences the epidermis in vitro.
Councillor loses legal battle over Derbyshire general practice
Authors: Owen Dyer
Journal: BMJ (2006)

A high court judge has ruled that a US owned health management company may take over a Derbyshire general practice, despite finding that the local primary care trust failed in its duty to consult patients who opposed the plan.

UnitedHealth Europe, a subsidiary of the Minnesota based United Health Group, beat 19 other bidders that had tendered for the contract to run GP services in the former mining village of Creswell and in the nearby branch surgery at Langwith.

But the award was challenged by a local parish councillor, Pam Smith, who sought judicial review of the decision, claiming that North Eastern Derbyshire Primary Care Trust failed to comply with section 11 of …
Infection Due to Bacterium Anitratum: A Study of Forty Patients.
Authors: R. C. Reynolds
Journal: Annals of Internal Medicine (1962)

s1 April 1962Infection Due to Bacterium Anitratum: A Study of Forty Patients.R. C. Reynolds, M.D., L. E. Cluff, M.D. (Assoc.)R. C. Reynolds, M.D.Search for more papers by this author, L. E. Cluff, M.D. (Assoc.)Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-56-4-689_2 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptForty patients with infection of varying severity and type attributable to Bacterium anitratum were observed and studied recently at the Johns Hopkins Hospital over an 18-month period. The clinical and bacteriological data of these infections have been analysed and are reported.Infection withBact. anitratumwas most common in the very young and the very old and often occurred in persons with some underlying serious illness. Septic abortion with bacteremia, hemorrhagic pneumonia, septicemia, pyelonephritis, and wound infections were the types of disease found to be attributable toBact. anitratum. Some of these infections, particularly in infants, led to a patient's... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Baltimore, Md. (CS) PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 April 1962Volume 56, Issue 4Page: 689-689KeywordsBacteremiaInfantsInfectious diseasesPneumoniaPyelonephritisSepsis Issue Published: 1 April 1962 PDF downloadLoading ...
PBX3 is an important cofactor of HOXA9 in leukemogenesis
Authors: Zejuan Li, Zhiyu Zhang, Yuanyuan Li, Stephen Arnovitz, Ping Chen, Hao Huang, Xi Jiang, Gia-Ming Hong, Rejani B. Kunjamma, Haomin Ren, Chunjiang He, Chong-Zhi Wang, Abdel G. Elkahloun, Peter J. M. Valk, Konstanze Döhner, Mary Beth Neilly, Lars Bullinger, Ruud Delwel, Bob Löwenberg, Paul P. Liu, Richard Morgan, Janet D. Rowley, Chun-Su Yuan, Jianjun Chen
Journal: Blood (2012)
GP recruits are offered 20 000 "golden hello" to work in Leicester
Authors: A. Rimmer
Journal: BMJ (2014)

GPs are being offered a £20 000 (€25 000; $32 000) incentive to take up posts in Leicester. The scheme, a joint initiative of Leicester City Clinical Commission Group, NHS England’s Leicestershire and Lincolnshire area team, and Leicester City Council, is using £250 000 of non-recurring primary medical care funding from the area team.

The money will be available to GPs who are new to the …
MicroRNA-29 Regulates T-Box Transcription Factors and Interferon-γ Production in Helper T Cells
Authors: David F. Steiner, Molly F. Thomas, Joyce K. Hu, Zhiyong Yang, Joshua E. Babiarz, Christopher D.C. Allen, Mehrdad Matloubian, Robert Blelloch, K. Mark Ansel
Journal: Immunity (2011)
(17) Primary amyloidosis
Authors: S.B. Bittiner, C.I. Harrington
Journal: British Journal of Dermatology (1986)

Journal Article (17) Primary amyloidosis Get access S.B. Bittiner, Drs, S.B. Bittiner, Drs Search for other works by this author on: Oxford Academic Google Scholar C.I. Harrington C.I. Harrington Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 115, Issue s30, 1 July 1986, Pages 61–62, https://doi.org/10.1111/j.1365-2133.1986.tb07712.x Published: 01 July 1986
Contribution of the murine mdr1a P-glycoprotein to hepatobiliary and intestinal elimination of cationic drugs as measured in mice with an<i>mdr1a</i>gene disruption
Authors: Johan W. Smit, Alfred H. Schinkel, Michael Müller, Betty Weert, Dirk K. F. Meijer
Journal: Hepatology (1998)

In the mouse, both the mdr1a and the mdr1b gene encode drug-transporting P-glycoproteins. The mdr1a P-glycoprotein is expressed in epithelial cells of, among others, the liver and the intestine. Furthermore, the mdr1b gene product is found in the liver but is not detectable in the intestine. To establish the potential involvement of P-glycoprotein in the elimination of cationic amphiphilic drugs from the body, we investigated biliary, intestinal, and urinary excretion in mice with a homozygous disruption of the mdr1a gene (mdr1a(−/−) mice). These mice are fully viable under laboratory conditions and have normal bile flow. Cumulative biliary excretion (expressed as percent of the intravenously administered dose excreted over a 1-hour period) of several cationic compounds was decreased as follows in mdr1a(−/−) mice compared with the wild-type animals: tri- n -butylmethylammonium (TBuMA), 0.7% versus 2.1%; azidoprocainamide methoiodide (APM), 3.8% versus 7.6%; and vecuronium, 22.7% versus 41.3% The luminal secretion of both TBuMA and APM in the small intestine was profoundly decreased, respectively 4.6-fold (1.8% vs. 8.2% in the wild-type) and 7.9-fold (1.6% vs. 10.3% in the wild-type) in mdr1a(−/−) mice. Thus mdr1a P-glycoprotein contributes substantially to the removal of a wide variety of cationic agents from the body through intestinal and hepatobiliary secretion, but it evidently acts in concert with other transport system(s). These processes probably provide a protective mechanism limiting the overall rate of absorption as well as the bioavailability of potentially toxic organic amines.
Polymorphisms of H-ras-1 and p53 in breast cancer and lung cancer: a meta-analysis.
Authors: A Weston, J H Godbold
Journal: Environmental Health Perspectives (1997)

Certain polymorphic variants of H-ras-1 and p53 have been investigated for an association between inheritance and cancer risk. The results of a metaanalysis, which reviews studies of H-ras-1 rare alleles and p53 codon 72 allelic variants in breast and lung cancer, are presented. The data constituted evidence for elevated risk of both breast and lung cancer with inheritance of rare H-ras-1 alleles. Calculated population attributable risks are 0.092 and 0.037 for breast and lung cancer, respectively. The frequency of the rare H-ras-1 alleles was observed to be greater in African Americans than in Caucasians, and a specific allele (A3.5) that is common in African Americans was found only at low frequency in Caucasians. For p53 a consensus has yet to be reached. Lung cancer studies conducted in Caucasian and African-American populations have found no evidence of risk associated with the proline variant of codon 72. Two similar studies conducted in Japanese populations suggested an association between p53 genotype distribution and lung cancer risk. However, one implicates the proline allele but the other implicates the arginine allele. The frequency of the proline variant is significantly dependent on race. Frequencies have been reported for control populations of Japanese (0.347 and 0.401), Caucasian (0.295, 0.284, and 0.214), African American (0.628 and 0.527), and Mexican American (0.263).
Equilibrium Multigated Blood Pool Ventriculography to Evaluate the Effects of High-Dose Gamma-Globulin Treatment for Left Ventricular Functions in Kawasaki Disease
Authors: CHIA-HUNG KAO, YUNG-CHUNG CHEN, KAI-SHENG HSIEH, SHYH-JEN WANG, SHIN-HWA YEH
Journal: Clinical Nuclear Medicine (1994)

Twenty-one patients with acute state Kawasaki disease (15 boys, 6 girls; age range, 1–8 years) had equilibrium multigated blood pool ventriculography (EMBPV) before treatment. The symptoms and signs subsided after the administration of aspirin and the intravenous injection of high-dose (400 mg/kg per day × 5 days) gamma-globulin (IVGG) treatment. Then, a second EMBPV was arranged to evaluate the effects of the treatment on left ventricular functions. Left ventricular function was analyzed based on the following parameters: (systolic phase) ejection fraction, ejection time, peak ejection rate, first 1/3 ejection rate mean; and (diastolic phase) peak filling rate, fast filling fraction, time to peak filling rate, first 1/3 filling rate mean. The results showed that there were no significant differences in the parameters of left ventricular function before and after treatment (P > 0.05, paired Student's t-tests).
Variable Content of Histaminase, L-Dopa Decarboxylase and Calcitonin in Small-Cell Carcinoma of the Lung
Authors: Stephen B. Baylin, William R. Weisburger, Joseph C. Eggleston, Geoffrey Mendelsohn, Michael A. Beaven, Martin D. Abeloff, David S. Ettinger
Journal: New England Journal of Medicine (1978)

Original Article from The New England Journal of Medicine — Variable Content of Histaminase, L-Dopa Decarboxylase and Calcitonin in Small-Cell Carcinoma of the Lung — Biologic and Clinical Implications