PLASMA THROMBOPLASTIN COMPONENT DEFICIENCY IN THE EHLERS-DANLOS SYNDROME
Authors: R LISKER, A NOGUERON, L SANCHEZ-MEDAL
Journal: Annals of Internal Medicine (1960)

Case Reports1 August 1960PLASMA THROMBOPLASTIN COMPONENT DEFICIENCY IN THE EHLERS-DANLOS SYNDROMERUBÉN LISKER, M.D., ARNOLDO NOGUERÓN, M.D., LUIS SÁNCHEZ-MEDAL, M.D.RUBÉN LISKER, M.D., ARNOLDO NOGUERÓN, M.D., LUIS SÁNCHEZ-MEDAL, M.D.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-53-2-388 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptINTRODUCTIONThe Ehlers-Danlos syndrome, fully described in a recent monograph by McKusick,1is a rare, congenital, hereditary disorder of the connective tissue with clear-cut clinical manifestations. Abnormal bleeding in this syndrome occurs frequently,2, 3and in some patients the hemorrhagic condition may be the prominent abnormality; Samuel et al.4reported a 32 year old female who gave a history of vaginal, rectal, nasal and cutaneous bleeding. The prominence of the bleeding in some cases led McKusick to state that this syndrome "must be included in the differential diagnosis of familial hemophilia-like states." The consensus regarding the physiopathology of the hemorrhagic...Bibliography1. McKusick VA: Heritable disorders of connective tissue, 1st Ed., 1956, The C. V. Mosby Company, St. Louis, pp. 86-108. Google Scholar2. Jacobs RH: Ehlers-Danlos syndrome. Report of a case with onset at age 29, Arch. Dermat. and Syph. 76: 460, 1957. CrossrefGoogle Scholar3. Summer GK: The Ehlers-Danlos syndrome, J. Dis. Child. 91: 419, 1956. CrossrefMedlineGoogle Scholar4. SamuelSchwartzMeister MAMLMM: The Ehlers-Danlos syndrome, U. S. Armed Forces M. J. 4: 737, 1953. MedlineGoogle Scholar5. FrickKrafchuk PGJD: Studies of hemostasis in the Ehlers-Danlos syndrome, J. Invest. Dermat. 26: 453, 1956. CrossrefMedlineGoogle Scholar6. Merskey C: Haemophilia associated with normal coagulation time, Brit. M. J. 1: 906, 1951. CrossrefMedlineGoogle Scholar7. SchulmanSmithErlandsonFortLee ICHMERE: Vascular hemophilia. A familial hemorrhagic disease in males and females characterized by combined antihemophilic globulin deficiency and vascular abnormality, Pediatrics 18: 347, 1956. MedlineGoogle Scholar8. SingerRamot KB: Pseudohemophilia type B, Arch. Int. Med. 97: 715, 1956. CrossrefGoogle Scholar9. ValbergBrown LSM: Haemorrhagic capillary disorder associated with antihaemophilic globulin deficiency, Medicine 37: 181, 1958. CrossrefMedlineGoogle Scholar10. RamotAngelopoulosSinger BBK: Variable manifestations of plasma thromboplastin component deficiency, J. Lab. and Clin. Med. 46: 80, 1955. MedlineGoogle Scholar11. Hardisty RM: Christmas disease in a woman, Brit. M. J. 1: 1039, 1957. CrossrefMedlineGoogle Scholar12. Husebye KO: Ehlers-Danlos syndrome, Arch. Dermat. and Syph. 78: 723, 1958. Google Scholar13. NilssonBergmanReitaluWaldenström IMSJJ: Hemofilia A in a girl with male sex-chromatin pattern, Lancet 2: 264, 1959. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: México, D. F.,*Received for publication March 2, 1960.From the Hospital de Enfermedades de la Nutritición, Dr. Jiménez 261, México, D. F., México.Requests for reprints should be addressed to Rubén Lisker, M.D., Hospital de Enfermedades de la Nutrición, Calle del Dr. Jiménez No. 261, México 7, D. F.,México. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byEhlers-Danlos syndromePlatelet and coagulation studies in Ehlers-Danlos syndromeEhlers-Danlos Syndrome with Recurrent BruisingEvidence that Charcot-Marie-Tooth disease with tremor coincides with the Roussy-Levy syndromeEhlers-Danlos Syndrome and Pregnancy: A Case of Uterine RuptureSindrome de ehlers-danlos asociado a pectus carinatusAbnormal Platelet-Collagen Reaction in Ehlers-Danlos SyndromeGastrointestinal complications of the Ehlers-Danlos syndromeObservations on the heart in a case of combined Ehlers-Danlos and Marfan syndromesVariants of the Ehlers-Danlos syndrome. Clinical, biochemical, haematological, and chromosomal features of 100 patients.OBSTETRIC ASPECTS OF THE EHLERS-DANLOS SYNDROMEBLADDER-NECK OBSTRUCTION AND THE EHLERS-DANLOS SYNDROMEHAEMORRHAGE INTO THE UPPER PART OF THE GASTRO-INTESTINAL TRACT IN THREE PATIENTS WITH HERITABLE DISORDERS OF CONNECTIVE TISSUEIrregular Blood CoagulationBilateral Spontaneous Carotid-Cavernous Fistulae in Ehlers-Danlos SyndromeEhlers-Danlos syndrome complicated by acute hemorrhagic sigmoid diverticulitis, with an unusual mitral valve abnormalityCardiovascular Aspects of the Ehlers-Danlos SyndromeFunctional and Ultrastructural Abnormalities of Platelets in Ehlers-Danlos SyndromeHEIHACHIRO KASHIWAGI, M.D., JEANNE M. RIDDLE, PH.D., JOSEPH P. ABRAHAM, M.D., BOY FRAME, M.D., F.A.C.P.Ehlers-Danlos Syndrome and Recurrent HemoptysisGEORGE A. ROBITAILLEEhlers-Danlos Syndrome and Multiple NeurofibromatosisROGER W. TURKINGTON, M.D., HARVEY E. GRODE, M.D.Ehlers-Danlos syndromeRheumatism and Arthritis Review of American and English Literature of Recent Years (Fifteenth Rheumatism Review)CHARLEY J. SMYTH, M.D., F.A.C.P., FELIX E. DEMARTINI, M.D., F.A.C.P., EPHRAIM P. ENGLEMAN, M.D., F.A.C.P., EDWARD C. FRANKLIN, M.D., DONALD F. HILL, M.D., F.A.C.P., JOSEPH LEE HOLLANDER, M.D., F.A.C.P., HOWARD L. HOLLEY, M.D., F.A.C.P., JOHN G. MAYNE, M.D., F.A.C.P., WILLIAM M. MIKKELSEN, M.D., F.A.C.P., MAX M. MONTGOMERY, M.D., F.A.C.P., CARL M. PEARSON, M.D., F.A.C.P., CHARLES L. SHORT, M.D., F.A.C.P., HUGH A. SMYTHE, M.D., F.R.C.P. (C), OTTO STEINBROCKER, M.D.Ehlers-Danlos syndrome with a sinus of valsalva aneurysm and aortic insufficiency simulating rheumatic heart diseaseEhlers-Danlos syndrome with cardiac involvementPurpuras: Diagnosis and TreatmentThe Ehlers-Danlos syndrome and multiple neurofibromatosis in a kindred of mixed derivation, with special emphasis on hemostasis in the Ehlers-Danlos syndromeMedical genetics 1960The Ehlers–Danlos Syndrome 1 August 1960Volume 53, Issue 2Page: 388-395KeywordsBlood plasmaConnective tissueGeneticsHemophilia BHemorrhage ePublished: 1 December 2008 Issue Published: 1 August 1960 PDF downloadLoading ...