tbuckley/cabot-search huggingface dataset:
SERUM PROPERDIN IN TUMOR-BEARING MICE. II. THE INFLUENCE OF TUMORS OF DIFFERENT ORIGIN.
Authors: Emanuel E. Schwartz, Seymour Winsten
Journal: Cancer Research (1964)

Summary  The growth of three tumors, of different cell type and origin, was associated with low levels of serum properdin in mice. This relationship was not observed in mice bearing a myeloid leukemia. Shigella antibody titers also remained relatively unaltered in the latter animals. Depression in properdin occurred toward the end of survival, at a time when the tumor hosts had reduced their food consumption and were losing weight. Similar serological changes could be produced by food deprival; this finding suggests that the relationship is probably nonspecific.
Abstract P402: A Rapid Automated Method Detects Probable Errors Among Sequential Clinical Measures Recorded During Clinical Care
Authors: Dawn C Schwenke
Journal: Circulation (2014)

Information collected during clinical care is increasingly used for research. Such data include errors and a rapid automated method for identifying likely errors is needed. This study aimed to develop a rapid automated method for identifying extreme values among sequential measures recorded during clinical care and to compare this method with the extreme studentized deviate many outlier procedure (ESD). Data were weights (W, n=1,151,434), heights (H, n=760,924), pulses (P, n=1,369,484), and systolic (S, n=1,680,583) and diastolic (D, n=1,680,503) blood pressures for 88,068 Veterans (82,874 men and 5,194 women) receiving care from the Phoenix VA Health Care System who had ≥5 five sequential values for these measures recorded in the electronic medical record during primary care visits from October 1999- September 2013. The new method identified extreme values by comparing individual values with three within-person metrics: 1. median (PMed), 2. interquartile range (PIQR), and 3. modified IQR [ModPIQR: PMed + / - smaller of (PMed - 25th percentile) and (75th percentile - PMed)]. These measures were selected because they were expected to be less perturbed by extreme values than the mean and standard deviation. Values exceeding cut-points (&gt; 99th or &lt; 1st population percentile) for ≥ 2 metrics were considered errors. High errors (0.46% W, 0.40% H, 0.55% P, 0.48% S, 0.50% D) were median 125%, 107%, 156%, 135% and 140% of PMed; median 3.3, 2.3, 2.8, 2.0 and 2.1 fold above PIQR; and median 5.0, 20, 3.4, 2.6, and 2.6 fold above ModPIQR for W, H, P, S, and D, respectively. Low errors (0.48% W, 0.43% H, 0.48% P, 0.46% S, 0.47% D) were 73%, 86%, 62%, 70%, and 65% of PMed; median 4.3, 5.0, 2.0, 1.8, and 2.1 fold below PIQR; and median 6.4, 50, 2.6, 2.3, and 2.4 fold below ModPIQR for W, H, P, S, and D. Compared with the new method, ESD (alpha = 0.01) identified fewer total (high+low) outliers for D (0.21% vs. 0.97%), P (0.58% vs. 1.03%), and S (0.14% vs. 0.94%), more outliers for H (2.40% vs. 0.83%), and similar numbers for W (0.70% vs. 0.94%). Both high (&gt; 99th population percentile) and low (&lt; 1st population percentile) extreme values for percent of PMed were detected with greater sensitivity by the new method (39%, 39%, 50%, 45%, and 46%; 41%, 40%, 43%, 41%, and 42%, respectively for high and low extremes for W, H, P, S, D) than by ESD (19%, 20%, 22%, 6%, 9% and 27%, 31%, 11%, 3%, 7%, respectively) while specificity was equally high (&gt;98%) for both methods. The new method can be easily implemented and effectively identifies extreme values likely to be errors from among sequential clinical measures and could help reveal underlying longitudinal trends in weight/BMI, blood pressure or other clinical measures.
Association of Cigarette Smoking and Smoking Cessation with Biochemical Recurrence of Prostate Cancer in Patients Treated with Radical Prostatectomy
Authors: Malte Rieken, Shahrokh F. Shariat, Luis A. Kluth, Harun Fajkovic, Michael Rink, Pierre I. Karakiewicz, Christian Seitz, Alberto Briganti, Morgan Rouprêt, Wolfgang Loidl, Quoc-Dien Trinh, Alexander Bachmann, Gholamreza Pourmand
Journal: European Urology (2015)
Rituximab With or Without a Conventional Maintenance Agent in the Treatment of Relapsing Granulomatosis With Polyangiitis (Wegener's): A Retrospective Single‐Center Study
Authors: Lama Azar, Jason Springer, Carol A. Langford, Gary S. Hoffman
Journal: Arthritis & Rheumatology (2014)

Objective To evaluate the efficacy and safety of rituximab (RTX) induction therapy and the duration of remission, when RTX is used with or without a conventional maintenance agent, in a cohort of patients with granulomatosis with polyangiitis (Wegener's) (GPA). Methods This was a retrospective, single‐center study of patients with relapsing GPA treated with at least 1 course of RTX (4 weekly doses of 375 mg/m 2 intravenously [IV] or 2 fixed doses of 1,000 mg IV 2 weeks apart). Complete remission was defined as the absence of disease activity measured by a Birmingham Vasculitis Activity Score for Wegener's granulomatosis of 0 and not qualified by the prednisone dosage at the time. Results Eighty‐nine patients achieved remission after their first course of RTX and were not re‐treated preemptively with RTX to maintain remission of their disease during followup. Among these patients, relapse‐free survival was significantly higher in those who received a conventional maintenance agent (azathioprine, methotrexate, or mycophenolate mofetil) in conjunction with RTX and glucocorticoids (n = 47) than in those who received no additional immunosuppressive agent (n = 42) ( P = 0.04). The hazard ratio of relapse in those receiving a maintenance agent was 0.53 (95% confidence interval 0.29–0.97). Serious adverse events did not differ between the 2 groups. Within a subset of 15 patients in the cohort who were relapse free 2 years after 1 course of RTX, remissions endured for 2–6 years in 8 patients. Conclusion RTX is an effective remission‐inducing agent in GPA. The addition of a conventional maintenance agent to RTX and glucocorticoids decreased the incidence of relapse and did not result in a higher incidence of adverse events.
A Novel Melanoma Gene (MG50) Encoding the Interleukin 1 Receptor Antagonist and Six Epitopes Recognized by Human Cytolytic T Lymphocytes
Authors: Malcolm S. Mitchell, June Kan-Mitchell, Boris Minev, Carl Edman, Robert J. Deans
Journal: Cancer Research (2000)

We identified a novel 8.1-kb human melanoma gene, MG50, derived from subtractive hybridization with a squamous lung carcinoma cell line, LU-1. 6.8 kb containing an open reading frame were sequenced, and the structure of the encoded 1496 amino acid protein was deduced. With HLA-A2.1-transduced Drosophila cells as antigen-presenting cells, we identified six epitopes restricted by HLA-A2.1 that elicited CTLs in vitro. Reactivity of the CTLs to melanoma cells containing MG50 indicated that the epitopes were displayed naturally. Significant cross-reactivity of CTLs immunized against a melanoma cell line that lacked HLA-A2.1 indicated that at least four of the epitopes were also recognized in a different HLA class I context, most likely HLA-A*6802. By quantitative reverse transcription, MG50 message was found in one of two skin melanoma cell lines, an ocular melanoma cell line, two of four metastatic skin melanomas, two of three mammary carcinomas, one of two colon carcinomas, and an ovarian carcinoma. Of six normal tissues, MG50 was found only in a specimen of normal skin and was absent from a congenital nevus. It is likely that MG50 is the gene for the interleukin 1 receptor antagonist because a reported sequence of cDNA from the latter had a sequence of 528 bases in the 3' region, a long contiguous base sequence, and 176 encoded amino acids identical with those of MG50. MG50 is one of the few melanoma-associated antigens that is not a differentiation antigen or a mutated protein. Because of its nature, it may prove to be important in the pathogenesis of the tumors in which it is found, as well as an immunogen and target for immunotherapy.
Abstract 15267: Plasma Apelin Level Contributes Exercise Training-induced Improvement of Arterial Stiffness in the Middle and Older Adults
Authors: Shumpei Fujie, Koji Sato, Natsuki Hasegawa, Satoshi Fujita, Kiyoshi Sanada, Takafumi Hamaoka, Motoyuki Iemitsu
Journal: Circulation (2014)

Aging-induced deterioration of arterial stiffness is decreased by regular exercise, and increased nitric oxide (NO) production participates in this effect. Apelin promotes NO production via upregulation of endothelial NO synthase. However, the association between exercise-training effects of arterial stiffness and circulating apelin level in healthy middle-aged and older adults remains unclear.   PURPOSE:  This study aimed to determine the time course of changes in plasma apelin level related to exercise-training effects of arterial stiffness in healthy middle-aged and older adults.   METHODS:  Thirty-two Japanese healthy middle-aged and older subjects (67 ± 1 years) were randomly divided into two groups: exercise intervention and sedentary controls. Subjects in the training group completed 8-week of aerobic exercise training (60-70% peak oxygen uptake [VO2peak] for 45 min, 3 days/week). VO2peak was measured as an index of cardiorespiratory fitness. We evaluated plasma nitrite/nitrate (NOx) and apelin concentrations and carotid-femoral pulse wave velocity (cfPWV), measured every 2 weeks for 8-week in the training group.   RESULTS:  VO2peak was significantly increased after the 8-week intervention. cfPWV was gradually declined from baseline to 8-week and significantly decreased after 8-week intervention (P    CONCLUSION:  These results suggest that the plasma apelin level was increased at the early stage of exercise training intervention and was associated with exercise training-induced alternation of arterial stiffness in the middle and older adults. Thus, plasma apelin level may be a predict biomarker of exercise training-induced improvement of arterial stiffness.
Band 3 Campinas: A Novel Splicing Mutation in the Band 3 Gene (AE1 ) Associated With Hereditary Spherocytosis, Hyperactivity of Na+/Li+ Countertransport and an Abnormal Renal Bicarbonate Handling
Authors: Paulo R.M. Lima, José A.R. Gontijo, José B. Lopes de Faria, Fernando F. Costa, Sara T.O. Saad
Journal: Blood (1997)
Abstract 19504: Factors Predicting Sinus Rhythm in Patients Cardioverted in the X-VERT Study
Authors: Michael D Ezekowitz, Riccardo Cappato, Allan Klein, Isabelle L Ming, Melanie Hemmrich, Martin van Eickels, Stefan H Hohnloser
Journal: Circulation (2014)

Introduction: The X-VERT trial is the first large, prospective study of a novel oral anticoagulant in patients undergoing elective cardioversion. Patients were randomized to rivaroxaban (20mg or 15mg once daily if the CrCl was between 30 and 49 ml/min) or Vitamin K antagonist (VKA) at a ratio of 2:1. Patients were assigned to an early or delayed cardioversion strategy per the local investigator’s judgment. Aim: To determine factors predictive of sustained sinus rhythm at the end of treatment (i.e. 6 weeks) after cardioversion. Methods: Patients with non-valvular AF of &gt;48 h or unknown duration were randomized. Univariate and multivariate analysis of logistic regressions were performed to detect potential predictors of clinically relevant variables. Results: A total of 1504 randomized patients were scheduled for either early (872 patients, 58%) or delayed (632 patients, 42%) cardioversion. 1398/1504 (93%) patients underwent cardioversion (electrical or pharmacological) or experienced spontaneous cardioversion during the treatment period. The time intervals from randomization to their first cardioversion (electrical n=1,253, pharmacological n=29 or spontaneous n=116) were 2.7 ± 2.8 days versus 27.9 ± 10.1 days for early versus delayed cardioversion. The acute success of their first cardioversion (electrical or pharmacological) was seen in 1107/1282 (86.3%) patients. At the end of treatment visit, 794/1504 (52.8%) patients were in sinus rhythm. In the multivariate analysis early cardioversion was a strong predictor of sustained sinus rhythm (p&lt;0.01). Conclusions: In X-VERT, early cardioversion was predictive of sustained sinus rhythm. Shorter duration AF correlated with sinus rhythm.
Selenium and asthma: a complex relationship
Authors: P. R. Hoffmann
Journal: Allergy (2008)

Descriptive studies in humans investigating the relationship between selenium (Se) status and asthma have presented inconsistent results. The concept of low Se status as a potential risk factor for increased prevalence or severity of asthma is based on the role that Se, through its incorporation into selenoproteins, plays as a potent antioxidant capable of augmenting the oxidative stress that accompanies asthma. However, Se intake also exerts a significant influence over immune responses. Thus, the dual effects of Se status on controlling oxidative stress in the lungs and regulating T helper 2 responses that drive allergic asthma, as well as which selenoproteins are key to regulating these processes, must be considered when attempting to decipher the relationship between this essential nutrient and complex allergic diseases such as asthma.
Lifestyle and parental allergen sensitization are reflected in the intrauterine environment at gene expression level
Authors: M. Joerink, M. A. W. Oortveld, F. Stenius, E. Rindsjö, J. Alm, A. Scheynius
Journal: Allergy (2010)

Environmental factors, including the intrauterine environment, can influence the risk of allergy development. In the present study, we investigated whether lifestyle and parental allergen sensitization status are reflected at gene expression level in the intrauterine environment. mRNA expression of 17 genes was determined by means of quantitative real-time PCR in term placenta of 36 families participating in the ALADDIN study (Assessment of Lifestyle and Allergic Disease During Infancy). Data were analysed using a linear regression model to estimate the influence of lifestyle and parental allergen sensitization on the relative mRNA expression levels. Immunohistochemistry on placenta biopsies was used to verify protein expression.Significant differences in mRNA expression levels were detected at the foetal side of the placenta, where CD14 was expressed at higher levels in placentas from families living on a farm compared to not living on a farm, and IL-12(p40) was expressed at lower levels when the father was sensitized compared to nonsensitized. At the maternal side of the placenta, higher expression of STAT4 and lower expression of GATA3 were detected in families with sensitized compared to nonsensitized mothers, and IL-12(p40) was lower expressed when the families were living on a farm compared to not living on a farm. Immunohistochemistry performed for STAT4 and GATA3 showed that protein and mRNA levels correlated well.Living on a farm and parental allergen sensitization are reflected in the intrauterine environment at the gene expression level.
Factors associated with irreversible airway obstruction in patients with asthma
Authors: Olga Kharevich, Irina Lapteva, Elena Lapteva
Journal: European Respiratory Journal (2014)

Introduction. Significant proportion of patients with asthma has irreversible airway obstruction (IAO) despite the adequate treatment.

The aim of the study was to reveal predictors of IAO in asthma patients.

Methods. Data from 141 adult patients with asthma were evaluated (38 males, 103 females, age 52.5±12.0 years, asthma duration 13.3±12.2 years). Patients with COPD, smoking history (≥10 pack-year) were not included. 78 patients (55%) had IAO defined as postbronhodilator FEV1/FVC≤70% pred. and/or postbronhodilator FEV1≤80% pred. Multivariate logistic regression was performed to identify factors associated with IAO in asthma.

Results. As compared with the patients with reversible airway obstruction or without obstruction, patients with IAO were older, more likely males, suffered from more severe disease, had longer disease duration, more frequent exacerbations and had history of allergic conditions less often. These parameters were included in multivariate logistic regression model. Continuous variables were previously dichotomized. The factors independently associated with presence of IAO were as follows: severe asthma (OR, 3.7; 95% CI, 1.41 to 9.59, p=0.007), male gender (OR, 5.2; 95% CI, 1.8 to 14.8, p=0.002) and disease duration >20 years (OR, 5.3; 95% CI, 1.8 to 16.1, p=0.003). History of allergic conditions was protective factor for IAO in asthma (OR, 0.38; 95% CI, 0.16 to 0.88, p=0.023).

Conclusion. Male patients with severe asthma and longer disease duration without history of allergic conditions are more likely to develop IAO. The occurrence of IAO in substantial part of asthma patients and its relations with some clinical and demographic parameters suggests heterogeneity of the disease.
Use of shuttle test on a group of healthy sugar cane workers, Sao Paulo, Brazil
Authors: Roseane Caldeira, Ana Maria Cartaxo, André Luis Albuquerque, Gustavo Prado, Dirce Zanetta, Mário Terra-Filho, Ubiratan de Paula Santos
Journal: European Respiratory Journal (2011)

Introduction:  The shutlle walking test (ST) is used to assess functional capacity in individuals with pulmonary diseases. Its use in healthy workers may be useful to evaluate exercise capacity. The practice of burning the sugar cane field in the night before harvest is common, and emits large amounts of pollutants.   Aims:  To evaluate the exercise capacity in a group of the burning sugar cane workers and a control group, during harvest and non-harvesting periods.   Methods:  112 sugar cane workers and 107 controls, young man, non-smokers were submitted to ST 2 periods. At the beginning and end of the test, heart rate (HR), respiratory frequency, blood pressure, SpO2, and Borg score were measured and the walking distance recorded. Data were analyzed and compared using t-test or Mann-Whitney Test.   Results:  The mean age, the body mass index (BMI) kg/m 2  and the HR were higher (p   Conclusions:  We demonstrated that sugarcane workers (SW) have better physical performance and exercise capacity than control subjects, although SW showed an elevation in diastolic blood pressure in ST, as observed in a previous study by our group.  Support by Conselho Nacional de Desenvolvimento Cientifico e Tecnolόgico (CNPq)/Brazil
New Heart Failure Guidelines Released
Authors: Rebecca Voelker
Journal: JAMA (2005)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Methods in health service research: Handling uncertainty in economic evaluations of healthcare interventions
Authors: A. H Briggs, A. M Gray
Journal: BMJ (1999)

This is the last of four articles

The constant introduction of new health technologies, coupled with limited healthcare resources, has engendered a growing interest in economic evaluation as a way of guiding decision makers towards interventions that are likely to offer maximum health gain. In particular, cost effectiveness analyses—which compare interventions in terms of the extra or incremental cost per unit of health outcome obtained—have become increasingly familiar in many medical and health service journals.

Considerable uncertainty exists in regard to valid economic evaluations Firstly, several aspects of the underlying methodological framework are still being debated among health economists. Secondly, there is often considerable uncertainty surrounding the data, the assumptions that may have been used, and how to handle and express this uncertainty. In the absence of data at the patient level sensitivity analysis is commonly used; however, a number of alternative methods of sensitivity analysis exist, with different implications for the interval estimates generated (see box). Finally, there is a substantial amount of subjectivity in presenting and interpreting the results of economic evaluations.

The aim of this paper is to give an overview of the handling of uncertainty in economic evaluations of healthcare interventions.3 It examines how analysts have handled uncertainty in economic evaluation, assembled data on the distribution and variance of healthcare costs, and proposed guidelines to improve current practice. It is intended as a contribution towards the development of agreed guidelines for analysts, reviewers, editors, and decision makers.4–7

#### Summary points

Economic evaluations are beset by uncertainty concerning methodology and data

A review of 492 articles published up to December 1996 found that a fifth did not attempt any analysis to examine uncertainty

Only 5% of these studies reported some measure of cost variance

Closer adherence to published guidelines would greatly improve the current position

Use …
The Bless Cloth
Authors: Dwalia South
Journal: JAMA (2004)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal