tbuckley/cabot-search huggingface dataset:
Dissemination of Psychotherapy for Trauma Spectrum Disorders in Postconflict Settings: A Randomized Controlled Trial in Rwanda
Authors: Nadja Jacob, Frank Neuner, Anna Maedl, Susanne Schaal, Thomas Elbert
Journal: Psychotherapy and Psychosomatics (2014)

&lt;b&gt;&lt;i&gt;Background:&lt;/i&gt;&lt;/b&gt; Dissemination of psychotherapeutic modules to local counselors seems a key requirement for coping with mental health disasters in conflict regions. We tested a train-the-trainer (TTT) dissemination model for the treatment of posttraumatic stress disorder (PTSD). &lt;b&gt;&lt;i&gt;Methods:&lt;/i&gt;&lt;/b&gt; We randomly assigned widowed or orphaned survivors of the 1994 Rwandan genocide with a PTSD diagnosis to narrative exposure therapy (NET) treatment (NET-1, n&lt;i&gt; = &lt;/i&gt;38) or to a 6-month waiting list (WL) condition to be followed by treatment (WL/NET-2, n = 38). Expert therapists trained a first dissemination generation of local Rwandan psychologists in NET complemented by 2 sessions of interpersonal psychotherapy modules. Under the supervision of the experts, these Rwandan psychologists (a) provided NET to the NET-1 participants and (b) subsequently trained and supervised a second generation of local psychologists. This second dissemination generation provided treatment to the WL/NET-2 group. The primary outcome measure was the Clinician-Administered PTSD Scale total score before therapy and at 3- and 12-month follow-ups. &lt;b&gt;&lt;i&gt;Results:&lt;/i&gt;&lt;/b&gt; At the 3-month follow-up, the NET-1 participants suffered significantly and substantially less from PTSD symptoms than the participants in the WL group. The treatment gains of NET-1 were maintained and increased at follow-up, with a within-group effect size of Cohen's d = 1.47 at the 12-month follow-up. After treatment by the second dissemination generation of therapists, the WL/NET-2 participants improved to an extent similar to that of the NET-1 group at follow-ups, with an effect size of Cohen's d = 1.37 at the 12-month follow-up. &lt;b&gt;&lt;i&gt;Conclusions: &lt;/i&gt;&lt;/b&gt;A TTT model of PTSD treatment dissemination can be effective in resource-poor postconflict societies.
Lucky seven?
Authors: 杨锃
Journal: Nature Medicine (2005)

电脑——还有什么我不会的!Windows，早就滚瓜烂熟；0ffice，当然运用自如；上互联网，不过家常便饭；编程序，我得好好想想……这东西有点烦，那干巴巴的程序、语言实在看不下去……其实，学编程很容易，我们可以先从趣味编程开始嘛！
Expression profiling of medulloblastoma: PDGFRA and the RAS/MAPK pathway as therapeutic targets for metastatic disease
Authors: Tobey J. MacDonald, Kevin M. Brown, Bonnie LaFleur, Katia Peterson, Christopher Lawlor, Yidong Chen, Roger J. Packer, Philip Cogen, Dietrich A. Stephan
Journal: Nature Genetics (2001)
Mandibular Advancement Therapy for Obstructive Sleep Apnea
Authors: Winfried J. Randerath
Journal: JAMA Internal Medicine (2015)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Internal Medicine HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Internal Medicine journal
Oral cyclophosphamide without corticosteroids to treat mucous membrane pemphigoid
Authors: E.M. Munyangango, C. Le Roux-Villet, S. Doan, F. Pascal, I. Soued, M. Alexandre, M. Heller, N. Lièvre, F. Aucouturier, F. Caux, L. Laroche, C. Prost-Squarcioni
Journal: British Journal of Dermatology (2012)

Mucous membrane pemphigoid (MMP) still represents a potentially life- and sight-threatening disease. Immunosuppressants, such as cyclophosphamide (CYC), are indicated for patients with severe and/or refractory MMP.To evaluate the efficacy and safety of daily oral CYC without corticosteroids as therapy for severe MMP.Thirteen patients with severe refractory MMP, who received oral CYC at an initial dose of 2 mg kg(-1) without corticosteroids, were retained. Previous treatments, for example dapsone, sulfasalazine or topical agents, were maintained during CYC treatment. Initial clinical severity and response to treatment were assessed by scoring. CYC was stopped after complete remission (CR), or when MMP progressed or lymphopenia (< 0·7 × 10(9) cells L(-1) ) occurred.After 52 weeks of CYC treatment, the overall response rate was 69% (9/13 patients) with a median time to disease control of 8 weeks (range 4-52 weeks). Seven patients (54%) entered CR with a median time to CR of 24 weeks (range 16-52 weeks), all remaining in CR at week 52. The mean duration of CYC administration was 12 weeks (range 2-52 weeks). The most common side effect was lymphopenia (10/13 patients), which led to CYC withdrawal for six patients. No sepsis was observed.CYC without corticosteroids had rapid efficacy in patients with severe refractory MMP and was safe.
Cellular effects of alpha particle radiation from radium-223: Alpharadin™, a new radiopharmaceutical for the treatment of skeletal metastases
Authors: Michael Dornish, Helene Heier-Baardson, Erik Pettersen
Journal: Cancer Research (2008)

AACR Annual Meeting-- Apr 12-16, 2008; San Diego, CA

5749 

Radium-223, a bone-seeking alpha emitting radionuclide, is the active component in Alpharadin™, a new radiopharmaceutical in clinical trials for the treatment of skeletal metastases from hormone-resistant prostate cancer. Alpha particles, positively charged helium nuclei, are >7000 times heavier than beta (s-) particles and have a high linear energy transfer (LET). As such, cellular damage from alpha radiation manifests in irrepairable DNA double-strand breaks. Often, only 1 hit by an alpha particle is sufficient to induce cell death. However, the path length of an alpha particle is far shorter than that of a beta particle,   1mm, respectively, depending on the particle energy. For radium-223, the half-life of which is 11.4 days, radioactive decay involves the release of 4 alpha particles. We have studied the cellular effects of radium-223 (Alpharadin) in vitro in NHIK 3025 cells, a cervical carcinoma cell line. We show that cells accumulate in G2 phase of the cell cycle following treatment with radium-223 at a high or low dose rate. A high dose rate corresponds to 5.8 mGy/min-28 mGy/min, while a low dose rate corresponds to 0.12 mGy/min-1.2 mGy/min. G2-arrest in cells appears to be permanent following treatment of cells with a radiation dose >0.35 Gy. Cytotoxicity was evaluated as a reduction in the colony-forming ability of treated single cells relative to radium-223 dose to medium. A reduction in cell survival followed the linear expression of a linear-quadratic model. Cytotoxicity induced by alpha particle irradiation from radium-223 was shown to be independent of dose rate. Similar survival curves were found irrespective if cells were treated in log growth or as quiescent cells in plateau phase. This demonstrates that alpha particle radiation induces cell killing whether or not cells are progressing through the cell cycle. Measurement of cellular ATP showed that treated cells were metabolically active for at least 48 hours after being exposed to radium-223. Using a cell line established for multidrug resistance (MDR) by continuous exposure to doxorubicin, we show that survival curves are identical for wild-type as well as MDR+ (P-glycoprotein-expressing) cells thereby demonstrating that chemoresistant cells are not resistant to the cell inactivating effects induced by alpha particle radiation. These data support the development of alpha particle radiation as a potential radiotherapeutic approach. Alpharadin (radium-223) has shown promising effects in a human Phase II clinical trial and a Phase III trial will begin in 2008.
766. Human Hematopoietic (CD34+) Stem Cells Possess High Affinity Receptors for Adenovirus Type 11p
Authors: Ya-Fang Mei, Anna Segerman, Kristina Lindman, Per Hörnsten, Anders Wahlin, Göran Wadell
Journal: Molecular Therapy (2004)

Gene transfer into human hematopoietic stem cells using Ad5 has been shown to be inefficient due to lack of the primary receptor CAR and the secondary receptors avβ3 integrin and avβ5 integrin, and due to the high seroprevalence of Ad5 antibodies in most adults, resulting in diminished gene transduction. In the present study, we screened 6 species (species A-F) of adenovirus, displaying different tropisms for interaction with CD34+ cells, at the level of virus attachment and expression. Virus particles were biotinylated and their binding capacity was determined by FACS analysis using streptavidin-FITC. Ad11p, Ad35 and Ad3 (species B) showed high binding affinity, while Ad7, Ad11a (species B) and Ad37 (species D) displayed intermediate affinity. Virions of Ad4 (species E), Ad5 (species C), Ad31(species A) and Ad41(species F) hardly bound to hematopoietic progenitor cells. By using a double-labeling system, we demonstrated that adenoviruses did bind to quiescent CD34+ cells. Ad11p virions showed the highest affinity. We further confirmed that virus fiber-specific receptors were present on the hematopoietic progenitor cell surface, since both recombinant fiber of Ad11p and specific antiserum against rfiber could block virus attachment. The ability of Ad11p, Ad35 and Ad5 to infect hematopoietic cells was studied by immunofluorescence staining. Ad11p and Ad35 showed higher infectivity than Ad5. Thus, we have confirmed that these cells have high affinity receptors for species B:2 human adenoviruses Ad11p and Ad35, and these viruses may be used as candidate vectors to target therapeutic genes to hematopoietic stem cells.
Loss-of-function mutations in TYROBP (DAP12) result in a presenile dementia with bone cysts
Authors: Juha Paloneva, Marjo Kestilä, Jun Wu, Antti Salminen, Tom Böhling, Vesa Ruotsalainen, Panu Hakola, Alexander B.H. Bakker, Joseph H. Phillips, Petra Pekkarinen, Lewis L. Lanier, Tuomo Timonen, Leena Peltonen
Journal: Nature Genetics (2000)
Abstract 4394: Genistein downregulates onco-miR-1260b and inhibits Wnt-signaling in renal cancer cells
Authors: Hiroshi Hirata, Koji Ueno, Yuichiro Tanaka, Z.Laura Tabatabai, Koichi Nakajima, Yuji Hinoda, Nobuhisa Ishii, Rajvir Dahiya
Journal: Cancer Research (2014)

Abstract Introduction and Objective: Wnt signaling plays an important role in renal cancer and that is modulated by genistein in other cancers. Recently microRNAs have emerged as new regulators of gene expression. Thus we focused on microRNAs to examine the regulatory mechanism of genistein on the Wnt signaling pathway in RCC. Methods: Initially we investigated the effect of genistein on Wnt signaling (TCF reporter assays) in renal cancer cells and using microarray identified candidate miRNAs whose expression was decreased by genistein. We performed functional analyses and investigated the relationship between miRNA expression and renal cancer patient outcomes. We also did 3′UTR luciferase assays to look at direct miRNA regulation of Wnt signaling related genes. Results: Genistein promoted apoptosis while inhibiting RCC cell proliferation and invasion. Genistein also decreased TCF reporter activity in RCC cells. We found that miR-1260b was highly expressed and significantly down-regulated by genistein in RCC cells. The expression of miR-1260b was significantly higher in renal cancer tissues compared to normal and significantly related to over-all shorter survival. Additionally miR-1260b promoted renal cancer cell proliferation and invasion in RCC cells. The 3′UTR luciferase activity of target genes (sFRP1, Dkk2, Smad4) was significantly decreased and their protein expression significantly up-regulated in miR-1260b inhibitor transfected renal cancer cells. Conclusions: Our data suggests that genistein inhibited Wnt signaling by regulating miR-1260b expression in renal cancer cells. Source of Funding: Grants RO1CA138642, RO1CA130860, RO1CA160079, I01BX001123, VA Merit Review and VA Program Project (PI: R. Dahiya). Citation Format: Hiroshi Hirata, Koji Ueno, Yuichiro Tanaka, Z.Laura Tabatabai, Koichi Nakajima, Yuji Hinoda, Nobuhisa Ishii, Rajvir Dahiya. Genistein downregulates onco-miR-1260b and inhibits Wnt-signaling in renal cancer cells. [abstract]. In: Proceedings of the 105th Annual Meeting of the American Association for Cancer Research; 2014 Apr 5-9; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2014;74(19 Suppl):Abstract nr 4394. doi:10.1158/1538-7445.AM2014-4394
Sterilization for Human Betterment: A Summary of Results of 6,000 Operations in California, 1909-1929.
Authors: E. S. Gosney, Paul Popenoe
Journal: JAMA (1930)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Budapest to privatise 11 hospitals
Authors: Carl Kovac
Journal: BMJ (2000)

Hungary's capital city, Budapest, has drawn up a plan to privatise 11 of the 19 hospitals under its jurisdiction, in an effort to pump new financial life into the cash strapped institutions.

Hungary's 160 hospitals, all owned by municipalities or state universities, are dependent on monthly allowances from the National Health Care Fund Administration, which barely cover their operating expenses.

This has resulted in poorly equipped facilities and a shortage …
Protection from Radiation-Induced Lethality by Chemical Mixture and Partial Body Shielding
Authors: R I WANG, J G KEREIAKES
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Interleukin‐1 Acts via the JNK‐2 Signaling Pathway to Induce Aggrecan Degradation by Human Chondrocytes
Authors: Heba M. Ismail, Kazuhiro Yamamoto, Tonia L. Vincent, Hideaki Nagase, Linda Troeberg, Jeremy Saklatvala
Journal: Arthritis & Rheumatology (2015)

Objective Aggrecan enables articular cartilage to bear load and resist compression. Aggrecan loss occurs early in osteoarthritis and rheumatoid arthritis and can be induced by inflammatory cytokines such as interleukin‐1 (IL‐1). IL‐1 induces cleavage of specific aggrecans characteristic of the ADAMTS proteinases. The aim of this study was to identify the intracellular signaling pathways by which IL‐1 causes aggrecan degradation by human chondrocytes and to investigate how aggrecanase activity is controlled by chondrocytes. Methods We developed a cell‐based assay combining small interfering RNA (siRNA)–induced knockdown with aggrecan degradation assays. Human articular chondrocytes were overlaid with bovine aggrecan after transfection with siRNAs against molecules of the IL‐1 signaling pathway. After IL‐1 stimulation, released aggrecan fragments were detected with AGEG and ARGS neoepitope antibodies. Aggrecanase activity and tissue inhibitor of metalloproteinases 3 levels were measured by enzyme‐linked immunosorbent assay. Low‐density lipoprotein receptor–related protein 1 (LRP‐1) shedding was analyzed by Western blotting. Results ADAMTS‐5 is a major aggrecanase in human chondrocytes, regulating aggrecan degradation in response to IL‐1. The tumor necrosis factor receptor–associated 6 (TRAF‐6)/transforming growth factor β–activated kinase 1 (TAK‐1)/MKK‐4 signaling axis is essential for IL‐1–induced aggrecan degradation, while NF‐κB is not. Of the 3 MAPKs (ERK, p38, and JNK), only JNK‐2 showed a significant role in aggrecan degradation. Chondrocytes constitutively secreted aggrecanase, which was continuously endocytosed by LRP‐1, keeping the extracellular level of aggrecanase low. IL‐1 induced aggrecanase activity in the medium in a JNK‐2–dependent manner, possibly by reducing aggrecanase endocytosis, because IL‐1 caused JNK‐2–dependent shedding of LRP‐1. Conclusion The signaling axis TRAF‐6/TAK‐1/MKK‐4/JNK‐2 mediates IL‐1–induced aggrecanolysis. The level of aggrecanase is controlled by its endocytosis, which may be reduced upon IL‐1 stimulation because of LRP‐1 shedding.
Abstract 4957: Racial Differences in Waitlist Mortality in Children Listed for Heart Transplant in the United States in the Current Era
Authors: Tajinder P Singh, Kimberlee Gauvreau, Ravi Thiagarajan, Gary Piercy, Christopher Almond
Journal: Circulation (2008)

Disparities in access and utilization of solid organ transplantation in racial minorities are well known in adults but not children. We assessed racial differences in waitlist mortality in children listed for heart transplant (HT) in the United States (US) in the current era. Data from the United Network of Organ Sharing for all US children&lt;18 years of age listed for primary HT during 1999 –2006 were analyzed. Clinical variables were defined at the time of listing. Race was defined as reported by HT centers. Multivariable Cox proportional hazards modeling was used to determine the relationship between race and waitlist mortality. Of 3299 listed children, 1913 (58%) were White, 657 (20%) were Black, 519 (16%) were Hispanic, 109 (3%) were Asian and the remaining 101 (3%) were defined as “Other”. The racial groups were similar with respect to distribution of listing status, percent patients on hemodynamic support and those with pre-formed antibodies &gt;10%. Black and Hispanic children lived in areas with lower median household income ($33,352, $37,516, and $43,077 for Black, Hispanic and White children respectively, P&lt;0.001) and were more likely to have Medicaid insurance compared to White children (58%, 59% and 24% respectively, P&lt;0.001). Waitlist mortality was 14% for White, 19% for Black, 21% for Hispanic, 17% for Asian and 27% for “Other” children. After controlling for age, cardiac diagnosis, listing status, hemodyamic support and creatinine clearance, Black (hazard ratio HR 1.6, 95% confidence interval CI 1.3–1.9, P&lt;0.001), Hispanic (HR 1.5, CI 1.2–1.9, P=0.001), Asian (HR, 2.1, CI 1.3–3.3, P=0.003) and “Other” children (HR 2.3, CI 1.5–3.4, P&lt;0.001) were all at higher risk for waitlist mortality compared to White children. After adjusting additionally for insurance and area household income, the risk of death remained higher for all nonwhite races (HR 1.4 for Black, 1.4 for Hispanic, 2.3 for Asian and 2.2 for “Other” children, P&lt;0.01 for all). Nonwhite children listed for heart transplant have higher waitlist mortality compared to White children after controlling for clinical risk factors. Socioeconomic variables explain only a small fraction of this increased risk.
A memorable moment: Love and respect after 30 years
Authors: T. Cubitt
Journal: BMJ (1999)

Footballers were playing in the field just over the neatly clipped hedge from the cemetery, their shirts uncomfortably brash against the faintly blue Lincolnshire sky, their imprecations and oaths almost swept away by the customary wind. Sue and I tended my parents' grave, briskly brushing the accumulated green stuff from the headstone. We stood back to look at the now much cleaner headstone An old man I had noticed in the distance came past pushing his bicycle, the …
Abstract 3711: School-based Early Prevention Interventions Decrease Body Mass Index Percentiles During School Year, but Children Experience Increase in Percentiles During Summer
Authors: Danielle Hollar, Theodore L Hollar, Arthur S Agatston
Journal: Circulation (2007)

Introduction: The Healthier Options for Public Schoolchildren (HOPS) Study aims to understand the efficacy of early prevention efforts addressing nutrition and physical activity in elementary school setting during the school year. Hypothesis: We assessed the hypotheses: HOPS interventions improve age and gender-specific body mass index (BMI) percentiles more so than traditional dietary and physical activities; intervention children maintain healthier BMI percentiles during summer vacation compared to controls. Methods: HOPS, in its 3 rd year, includes approximately 3,200 children (48% Hispanic) in six elementary schools (4 intervention; 2 control). Data are collected in fall and spring. Interventions include modified dietary offerings, nutrition and lifestyle curricula, school gardens, and other wellness projects, with the goal of reducing childhood obesity rates in a manner that is replicable in other public school settings. Results: Overall, data for the academic year 2 show statistically significant differences between treatment groups with respect to changes in BMI percentiles. Analyses of subgroups show trends towards greater improvements for intervention children, but only those classified as normal and in the 3 rd quintile at study baseline experienced statistically significantly improvement. Data analyzed for summer vacation time show increases in BMI percentiles for both intervention and control children with the exception of intervention children classified as overweight or in the 5 th quintile at study baseline. Control children classified as at risk or overweight as well as those in the 3 rd , 4 th , and 5 th quintiles experienced greater increases in their BMI percentiles during summer. Conclusions: Early results show HOPS interventions improve BMI percentiles of elementary-aged children during the school year. However, all children appear to be losing ground during summer vacation as their BMI percentiles increase during this time. Changes in BMI Percentiles during School Year