tbuckley/cabot-search huggingface dataset:
Asthma--expiratory dyspnoea?
Authors: C K Connolly
Journal: BMJ (1982)

Industrial bladder cancer SIR,-In a leading article on industrial bladder cancer (27 February, p 614) Robin Glashan claims that evidence from a study by Vineis et al purports to show that engineering workers using lubricating oil are at risk.'The paper by Vineis gives the results of a study into the incidence of larynx, bladder, and infantile tumours occurring among residents of towns in the province of Turin in the period 1965-9 and is in Italian.A careful reading of the paper, and the English abstract, reveals no reference to lubricating oil, greases, or lubricant in any form.I feel it is important to put this correction on record as there is no evidence either from this article or elsewhere that workers using lubricant oils are at any special risk of bladder cancer.
Combined Use of ALK Immunohistochemistry and FISH for Optimal Detection of ALK-Rearranged Lung Adenocarcinomas
Authors: Lynette M. Sholl, Stanislawa Weremowicz, Stacy W. Gray, Kwok-Kin Wong, Lucian R. Chirieac, Neal I. Lindeman, Jason L. Hornick
Journal: Journal of Thoracic Oncology (2013)
The Spatial Vectorcardiogram and Mean Spatial Ventricular Gradient in Normal Pregnant Women
Authors: G. E. BURCH, J. A. ABILDSKOV, J. A. CRONVICH
Journal: Circulation (1954)

The spatial vectorcardiogram and the spatial ventricular gradient of normal subjects in the last trimester of pregnancy and in some of the same subjects following delivery have been studied. It was found that the vectorcardiograms could be divided into two groups on the basis of the form of the QRS sÊ-loops, as has been previously reported for other normal subjects. In some instances records taken after delivery or records taken during pregnancy with the subject in deep inspiration altered both the orientation and the form of the QRS sÊ-loop. Since these alterations were most likely due to changes in position of the heart and extracardiac tissues, it is suggested that these are factors determining the configurations of the two types of normal QRS sÊ-loops.
Levodopa and Pyridoxine Co-Administration: Differential Metabolie Effect in Parkinsonian and Normal Subjects.
Authors: J. R. Bianchine
Journal: Annals of Internal Medicine (1973)

Meeting Abstracts1 May 1973Levodopa and Pyridoxine Co-Administration: Differential Metabolie Effect in Parkinsonian and Normal Subjects.J. R. Bianchine, M.D., F.A.C.P., T. H. Hsu, M.D., T. J. Preziosi, M.D., F. S. Messiha, Ph.D.J. R. Bianchine, M.D., F.A.C.P.Search for more papers by this author, T. H. Hsu, M.D.Search for more papers by this author, T. J. Preziosi, M.D.Search for more papers by this author, F. S. Messiha, Ph.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-78-5-830_2 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptPyridoxine when coadministered with levodopa to parkinsonian patients may negate levodopa's therapeutic effect. Since pyridoxal 5-phosphate is a cofactor for transaminase and dopa-decarboxylase, it may accelerate levodopa metabolism. To test this possible explanation for this therapeutic impairment, we studied the effect of pyridoxine administration on levodopa metabolism in four consenting normal and five parkinsonian subjects. Both groups received levodopa, 2 g/day (0.5 g by mouth four times daily) for 2 weeks before simultaneous coadministration of pyridoxine (50 mg by mouth three times daily) for 2 consecutive days. Serial urine collections were made on the day before and during pyridoxine coadministration... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Baltimore, Maryland. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byDIFFERENTIATION IN BRAIN AND LIVER DOPA/SHTP DECARBOXYLASE ACTIVITY AFTER L-DOPA ADMINISTRATION WITH OR WITHOUT PYRIDOXINE IN CATS 1 May 1973Volume 78, Issue 5Page: 830-830KeywordsAminotransferasesLevodopaMouthPyridoxineUrine Issue Published: 1 May 1973 PDF downloadLoading ...
The Association Between H3K4me3 and Antisense Transcription
Authors: Peng Cui, Wanfei Liu, Yuhui Zhao, Qiang Lin, Feng Ding, Chengqi Xin, Jianing Geng, Shuhui Song, Fanglin Sun, Songnian Hu, Jun Yu
Journal: Genomics Proteomics & Bioinformatics (2012)

Abstract Histone H3 lysine 4 trimethylation (H3K4me3) is well known to occur in the promoter region of genes for transcription activation. However, when investigating the H3K4me3 profiles in the mouse cerebrum and testis, we discovered that H3K4me3 also has a significant enrichment at the 3′ end of actively transcribed (sense) genes, named as 3′-H3K4me3. 3′-H3K4me3 is associated with ∼15% of protein-coding genes in both tissues. In addition, we examined the transcriptional initiation signals including RNA polymerase II (RNAPII) binding sites and 5′-CAGE-tag that marks transcriptional start sites. Interestingly, we found that 3′-H3K4me3 is associated with the initiation of antisense transcription. Furthermore, 3′-H3K4me3 modification levels correlate positively with the antisense expression levels of the associated sense genes, implying that 3′-H3K4me3 is involved in the activation of antisense transcription. Taken together, our findings suggest that H3K4me3 may be involved in the regulation of antisense transcription that initiates from the 3′ end of sense genes. In addition, a positive correlation was also observed between the expression of antisense and the associated sense genes with 3′-H3K4me3 modification. More importantly, we observed the 3′-H3K4me3 enrichment among genes in human, fruitfly and Arabidopsis, and found that the sequences of 3′-H3K4me3-marked regions are highly conserved and essentially indistinguishable from known promoters in vertebrate. Therefore, we speculate that these 3′-H3K4me3-marked regions may serve as potential promoters for antisense transcription and 3′-H3K4me3 appear to be a universal epigenetic feature in eukaryotes. Our results provide a novel insight into the epigenetic roles of H3K4me3 and the regulatory mechanism of antisense transcription.
Are measures of patient satisfaction hopelessly flawed?
Authors: J. L. Haggerty
Journal: BMJ (2010)

No, but they need further refinement

Measures of patient satisfaction and the patient experience—as instituted in the UK Quality and Outcomes Framework for primary care—supply feedback that helps health professionals provide patient centred care; they also give insight about the interpersonal dimension of quality of care as a complement to the technical quality of care. In the linked study (doi:10.1136/bmj.c5004), Salisbury and colleagues explore whether responses to questions in patient surveys that claim to assess the performance of general practices or doctors reflect differences between the practices, the doctors, or the patients themselves.1 The analysis separates the variance in patient satisfaction and patient experience into that attributed to differences between practices and those between doctors. The study found that when patients were asked a single question about how satisfied overall they were with their practice, only 4.6% of the variance in their satisfaction ratings was a result of differences between practices; the remaining variance resulted from differences between patients plus random error. In contrast, when asked to report on their experience with usual time they had to wait for an appointment, more than 20% of the variance in responses was a result of differences between practices. The authors …
Review: Several bedside instruments are accurate for diagnosing delirium in hospitalized patients
Authors: Audrey Chun, Rosanne M. Leipzig
Journal: Annals of Internal Medicine (2011)

ACP Journal Club15 February 2011Review: Several bedside instruments are accurate for diagnosing delirium in hospitalized patientsAudrey Chun, MD, Rosanne M. Leipzig, MD, PhDAudrey Chun, MDMount Sinai School of Medicine, New York, New York, USA (A.C., R.M.L.)Search for more papers by this author, Rosanne M. Leipzig, MD, PhDMount Sinai School of Medicine, New York, New York, USA (A.C., R.M.L.)Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-154-4-201102150-02012 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail Source CitationWong CL, Holroyd-Leduc J, Simel DL, Straus SE. Does this patient have delirium? Value of bedside instruments. JAMA. 2010;304:779-86. https://pubmed.ncbi.nlm.nih.gov/20716741Clinical Impact RatingsHospitalists: Geriatrics: References1 Inouye SK. Delirium in older persons. N Engl J Med. 2006;354:1157-65. [PMID: 16540616] Google Scholar2 Inouye SK. The Confusion Assessment Method (CAM): Training Manual and Coding Guide. New Haven: Yale University School of Medicine. 2003. http://elderlife.med.yale.edu/pdf/The%20Confusion%20Assessment%20Method.pdf (accessed 11 Nov 10). Google Scholar3 Wei LA, Fearing MA, Sternberg EJ, Inouye SK. The Confusion Assessment Method: a systematic review of current usage. J Am Geriatr Soc. 2008;56:823-30. [PMID: 18384586] Google Scholar Author, Article, and Disclosure InformationAuthors: Audrey Chun, MD; Rosanne M. Leipzig, MD, PhDAffiliations: Mount Sinai School of Medicine, New York, New York, USA (A.C., R.M.L.)This article was published at Annals.org on 1 February 2011. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 15 February 2011Volume 154, Issue 4Page: JC2-12KeywordsDeliriumIntensive care unitsLikelihood ratioLungsMini mental state examinationPopulation statisticsProspective studiesSpecificitySystematic reviewsVital signs ePublished: 15 February 2011 Issue Published: 15 February 2011 Copyright & PermissionsCopyright © 2011 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
A Low-Carbohydrate, Ketogenic Diet versus a Low-Fat Diet To Treat Obesity and Hyperlipidemia
Authors: William S. Yancy, Maren K. Olsen, John R. Guyton, Ronna P. Bakst, Eric C. Westman
Journal: Annals of Internal Medicine (2004)

Background: Low-carbohydrate diets remain popular despite a paucity of scientific evidence on their effectiveness. Objective: To compare the effects of a low-carbohydrate, ketogenic diet program with those of a low-fat, low-cholesterol, reduced-calorie diet. Design: Randomized, controlled trial. Setting: Outpatient research clinic. Participants: 120 overweight, hyperlipidemic volunteers from the community. Intervention: Low-carbohydrate diet (initially, <20 g of carbohydrate daily) plus nutritional supplementation, exercise recommendation, and group meetings, or low-fat diet (<30% energy from fat, <300 mg of cholesterol daily, and deficit of 500 to 1000 kcal/d) plus exercise recommendation and group meetings. Measurements: Body weight, body composition, fasting serum lipid levels, and tolerability. Results: A greater proportion of the low-carbohydrate diet group than the low-fat diet group completed the study (76% vs. 57%; P = 0.02). At 24 weeks, weight loss was greater in the low-carbohydrate diet group than in the low-fat diet group (mean change, −12.9% vs. −6.7%; P < 0.001). Patients in both groups lost substantially more fat mass (change, −9.4 kg with the low-carbohydrate diet vs. −4.8 kg with the low-fat diet) than fat-free mass (change, −3.3 kg vs. −2.4 kg, respectively). Compared with recipients of the low-fat diet, recipients of the low-carbohydrate diet had greater decreases in serum triglyceride levels (change, −0.84 mmol/L vs. −0.31 mmol/L [−74.2 mg/dL vs. −27.9 mg/dL]; P = 0.004) and greater increases in high-density lipoprotein cholesterol levels (0.14 mmol/L vs. −0.04 mmol/L [5.5 mg/dL vs. −1.6 mg/dL]; P < 0.001). Changes in low-density lipoprotein cholesterol level did not differ statistically (0.04 mmol/L [1.6 mg/dL] with the low-carbohydrate diet and −0.19 mmol/L [−7.4 mg/dL] with the low-fat diet; P = 0.2). Minor adverse effects were more frequent in the low-carbohydrate diet group. Limitations: We could not definitively distinguish effects of the low-carbohydrate diet and those of the nutritional supplements provided only to that group. In addition, participants were healthy and were followed for only 24 weeks. These factors limit the generalizability of the study results. Conclusions: Compared with a low-fat diet, a low-carbohydrate diet program had better participant retention and greater weight loss. During active weight loss, serum triglyceride levels decreased more and high-density lipoprotein cholesterol level increased more with the low-carbohydrate diet than with the low-fat diet.
Treatment of pulmonary hypertension in chronic bronchitis and emphysema.
Authors: P J Wallis, J A Wedzicha, D W Empey
Journal: BMJ (1985)

Sir,?We read with interest the leading article by Dr John Rees on the treatment of pulmonary hypertension in patients with chronic bronchitis and emphysema (24 November, p 1398). An appreciable, but unknown, number of patients with hypoxia also develop polycythaemia, and in these cases reducing packed cell volume may help to ameliorate pulmonary hypertension. Blood viscosity rises exponentially with increasing packed cell volume,1 and experi? mental evidence shows that this produces a significant increase in pulmonary artery pressure and pulmonary vascular resistance,2 particularly at packed cell volumes above 0-55. Furthermore, the increased viscosity of polycythaemic blood contributes significantly to the raised pulmonary vascular resistance that occurs in the presence of chronic hypoxia.3 Reducing packed cell volume in patients with polycythaemia secondary to hypoxic cor pulmonale by repeated venesections,4 dextran 40 exchange transfusion,5 or, more recently, erythrapheresis,6 produces significant reductions in pulmonary artery pressure and pulmonary vascular resistance. Erythrapheresis also produces both symptomatic benefit and improvement in work performance.7 Con? sequently reducing packed cell volume to about 0-50 should be considered as an additional therapeutic option in patients with polycythaemia and pulmonary hypertension secondary to chronic bronchitis and emphysema.
New e-Prescribing Guide Unveiled
Authors: Bridget M. Kuehn
Journal: JAMA (2008)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Qualitative Research in Health Care
Authors: P. Alderson
Journal: BMJ (1996)

Ed Nicholas Mays, Catherine Pope BMJ Publishing Group, pounds sterling10.95, pp 79 ISBN 0 7279 1013 2

Why does evidence from meticulous trials have so little impact on clinical practice? How do the ways in which clinical teams coordinate their work affect patients' outcomes? Why do many people accept advice on “healthy living” but not put it into practice? These and many similar questions relate to the perplexing gaps between research evidence and its effective use, between health services and outcomes, and between personal knowledge …
Amoxicillin/clavulanate vs placebo: more exacerbation cures, fewer recurrences in mild-to-moderate COPD
Authors: Sandra G. Adams, Jay I. Peters
Journal: Annals of Internal Medicine (2013)

Source Citation Llor C, Moragas A, Hernández S, Bayona C, Miravitlles M. Efficacy of antibiotic therapy for acute exacerbations of mild to moderate chronic obstructive pulmonary disease. Am J Respir Crit Care Med. 2012;186:716-23. 22923662
Digital Subtraction Angiography for Localization of Parathyroid Lesions
Authors: JONATHAN M. LEVY
Journal: Annals of Internal Medicine (1982)

Transvenous digital subtraction angiography was used before surgery to evaluate seven patients with chemical evidence of hyperparathyroidism. Digital subtraction angiography identified parathyroid adenomas in six of the seven patients. This technique is a sensitive, although not specific, method to identify small vascular tumors.
Fifty mice cloned by new technique
Authors: J. H. Tanne
Journal: BMJ (1998)

An international team of scientists led by Dr RyuzoYanagimachi from the University of Hawaii in Honolulu has cloned more than 50 mice in several experiments, using a new technique that represents a significant step forward in cloning technology (Nature 1998;394:369-74).

In the same issue of Nature, scientists at the Roslin Institute in Scotland have been cleared of accusations that Dolly, the first mammal to be cloned from differentiated adult cells, was not in fact a clone. Two groups of researchers have shown by microsatelliteanalysis and DNA fingerprinting that Dolly is a true clone (Nature 1998;394:329 and 329-30).

Dr Teruhiko Wakayama, a researcher at the University of Tokyo, pioneered the new cloning technique, which involved injecting nuclei from terminally differentiated somatic cells (Sertoli, neuronal, and cumulus cells) into enucleated mouse oocytes. The oocytes were left …
Cardiovascular Reactivity, Hostility, and Family History of Hypertension
Authors: Randall S. Jorgensen, Kent Houston
Journal: Psychotherapy and Psychosomatics (1988)

This study was conducted to evaluate the relations between cardiovascular reactivity and two types of hostility, namely, overt expression of hostility in contrast to the covert experience of hostility. Diastolic blood pressure reactivity was associated with not overtly expressing hostility. For persons with a parental history of hypertension, systolic blood pressure (SBP) reactivity was associated with low scores on the covert hostility measure of irritability, while for persons without a parental history of hypertension, SBP reactivity was associated with high scores for irritability. The results are discussed in light of research in the area of cardiovascular reactivity and stress-related cardiovascular disease.
1144-129 Optimal preload adjustment of right ventricular power allows for single beat estimation of contractility
Authors: Soren Schenk, Zoran B Popovic, Patrick M McCarthy, Yoshie Ochiai, Randall C Starling, Jose L Navia, Yoshio Ootaki, Keiji Kamohara, James D Thomas, Kiyotaka Fukamachi
Journal: Journal of the American College of Cardiology (2004)
The effects of cyclic stretch on gene transfer in alveolar epithelial cells
Authors: Winna Taylor, Kerimi E Gokay, Chris Capaccio, Erica Davis, Matthew Glucksberg, David A Dean
Journal: Molecular Therapy (2003)

Cyclic stretch has been shown to alter cell physiology, cytoskeletal structure, signal transduction, and gene expression in a variety of cell types. To determine the effects of stretch on the gene transfer process, we compared the transfection efficiencies of human A549 cells grown either statically or exposed to 10% cyclic stretch (Delta surface area) at 60 cycles/min (1 Hz) for 24 hours prior to, and/or after transfection with pEGFP-N1 and pCMV-lux-DTS using lipoplex or electroporation. Stretching the cells prior to transfection had no effect on gene transfer. By contrast, cyclic, but not continuous, stretch applied immediately after transfection for as little as 30 minutes resulted in a 10-fold increase in gene transfer and expression by either transfection technique. These stretch conditions did not result in rupture of the plasma membrane based on the fact that DNA was unable to enter stretched cells unless either an electric field was applied or the DNA was complexed with liposomes. Taken together with the timing of the stretch response and the known effects of stretch on transcription, these findings suggest that cyclic stretch may be altering the intracellular transport of plasmids to increase gene expression.
The Adopted-Away Offspring of Schizophrenics
Authors: DAVID ROSENTHAL, PAUL H. WENDER, SEYMOUR S. KETY, JOSEPH WELNER, FINI SCHULSINGER
Journal: American Journal of Psychiatry (1971)

In this study, adopted-away children of schizophrenics were compared with 67 controls—adoptees whose parents had no known psychiatric history. The rate of diagnoses in the "schizophrenia spectrum" was 31.6 percent for the entire index group, compared to 17.8 percent for the control group. The authors believe that evidence from this study supports the theory that heredity plays a significant role in the etiology of schizophrenia spectrum disorders.
STUDIES ON THE D'HÉRELLE PHENOMENON
Authors: André Gratia
Journal: The Journal of Experimental Medicine (1921)

The inhibition produced by the lytic agent on the growth of Bacillus coli is greatly influenced by the reaction of the medium; it is faint in a slightly acid (pH 6.8) or neutral (pH 7) or even slightly alkaline broth (pH 7.4), but is much stronger in a more alkaline medium (pH 8 or 8.5). We have isolated from the original strain of Bacillus coli two types of organisms; one (Type S) is sensitive to the lytic agent, the other (Type R) is much more resistant. These types are distinguished also by other characteristics: Type S grows quickly in artificial medium and is non-motile; Type R grows more slowly, is extremely motile, much less phagocytable, and more virulent. Both types produce indole and ferment carbohydrates, with the exception of saccharose. Both types keep their individuality even after passage through a guinea pig. We have also demonstrated that even a culture of a single type, Type S for instance, is not a homogeneous whole but is made up of organisms of varying resistance to the lytic agent; only a few are resistant enough to overcome the strong action of the undiluted lytic agent. On the other hand, only a few as well are sufficiently sensitive to be dissolved even by very dilute lytic agent. This explains why dilute lytic agent spread on an agar plate seeded with Bacillus coli confines its action only to certain places and produces the small round areas of dissolution that d'Hérelle considered as "colonies of bacteriophage." Moreover, we have observed the same localized action even with non-dilute lytic agent when submitting to its action cultures of greater resistance. Our original lytic agent was found to be specific; it acted exclusively on the coli with which the guinea pigs were injected. By allowing this original lytic principle to act on broth cultures of our two types of Bacillus coli, we have obtained two new filtrates. The first, resulting from dissolution of the sensitive Strain S, is specific as is the original filtrate. But with the second, obtained from the resistant Strain R, Dr. Wollstein has found a marked action on Shiga, on Flexner, and on Hiss dysentery bacilli. In consequence of this observation, we have been able, by a method of successive passages through appropriate strains, to extend the lytic power to other species, as typhoid and paratyphoid bacilli, and have obtained by this somewhat different technique results similar to those recently published by Bordet and Ciuca.