tbuckley/cabot-search huggingface dataset:
Update on the new variant of Chlamydia trachomatis: Prevalence and diagnostics
Authors: B Herrmann
Journal: Eurosurveillance (2008)

In 2006, a new variant of Chlamydia trachomatis (nvCT) was discovered in Sweden [1]. Due to a deletion in the target sequence for PCR amplification, nvCT has escaped detection by the nucleic acid amplification tests Abbott m2000 (Abbott Laboratories) and Cobas Amplicor/TaqMan48 (Roche Diagnostics) which together were used for 65% of all chlamydia tests in Sweden. The third test commonly used in Sweden, ProbeTec ET (Becton Dickinson [BD]), does detect the new variant because it uses a different DNA target sequence in the cryptic plasmid. The nvCT is spread all over Sweden and in early 2007, it accounted for between 20% and 65% of all chlamydia cases in Swedish counties where Abbott/Roche test systems were used [2]. In the four counties that used the BD system, the proportion of nvCT was only between 7% and 20% in the same time period. Ongoing studies are now following the spread of the nvCT in several counties.
Praktische Hämatologie. Differentialdiagnose. Therapie. Methodik.
Authors: Herbert Begemann, H.-G. Harwerth
Journal: Annals of Internal Medicine (1967)

Eisenstoffwechsel: Beitr\l=a\gezur Forschung und Klinik. Edited by W. Keiderling. Price, $11.40. Pp. 294, with 138 charts and illustrations. Georg Thieme Verlag, Herdweg 63, (14a) Stuttgart N, 1959. This is a Festschrift written by thirty international authorities on the occasion of Prof. Dr. Ludwig Heilmeyer's sixtieth birthday. It is a beautiful book\p=m-\wellconceived, well executed, and well presented. All aspects of iron metabolism are covered in careful detail, and the information relative to this field is brought up to date. Each paper, in addition to presenting an excellent review of its subject matter, contains an extensive bibliography. This is an excellent source book for all those interested in iron metabolism, whether from the laboratory or the clinical viewpoint. It is unfortunate that the book is trilingual, some of the papers being in German, others in English, and still others in French. Steven O. Schwartz, M.D.
SAR analysis of substituted purines as topoisomerase II inhibitors identifies ATPase inhibitors with nanomolar activity.
Authors: Lars H. Jensen, Peter B. Jensen, Robert H. Shoemaker, Maxwell Sehested
Journal: Cancer Research (2006)

Proc Amer Assoc Cancer Res, Volume 47, 2006

5535 

We have previously identified [NSC35866][1] a S6 substituted analog of guanine as a catalytic inhibitor of topoisomerase II in vitro and in cells. We here present data on a SAR analysis including various other S6 and 06 substituted purines derived from the NCI's drug repository and from commercial sources. We assessed the effect of these compounds on human topoisomerase II α ATPase activity in the presence of DNA. Three closely related compounds NSC348400, NSC348401 and NSC348402 were found to inhibit the ATPase reaction human topoisomerase II α with IC50 values in the high nanomolar range in the absence of DTT, and in the low micromolar range in the presence of DTT. These compounds did not increase the level of topoisomerase II covalent complex with DNA in vitro , and NSC348401 could even antagonize the DNA cleavage-promoting effect of etoposide in vitro . However, in contrast to [NSC35866][1], which could antagonize etoposide-induced DNA breaks and toxicity in cells, NSC348401 was unable to antagonize these etoposide-induced effects and was instead cytotoxic. This result suggests that [NSC35866][1] and NSC348401 interact differently with topoisomerase II, which is further suggested by the finding that the activity of [NSC35866][1] is lost upon removal of a C2 attached amino functionality, while the presence of this group has no impact on the potency of NSC348401.We conclude that the nature of C6 substitutions in purine analogs influences their mode of interaction with topoisomerase II.

 [1]: /lookup/external-ref?link_type=GENPEPT&access_num=NSC35866&atom=%2Fcanres%2F66%2F8_Supplement%2F1301.4.atom
First cases of human germline genetic modification announced
Authors: A. Ferriman
Journal: BMJ (2001)

The genetics watchdog in Britain has recommended a three year ban on the use of genetic test results by insurance companies after the industry failed to prevent its members from using unapproved tests.

The Human Genetics Commission has added an extra 12 months to the moratorium on the use of genetic test results recommended by MPs last month (14 April, p 883). The time is needed to gather more information on the complex issues …
Skin photodynamic therapy in severe localized atopic dermatitis: a case report
Authors: G. Pozzi, R. Asero
Journal: British Journal of Dermatology (2010)

Conflicts of interest: none declared. Madam, Skin photodynamic therapy (PDT) is a technique that combines the administration of porphyrins or porphyrin precursors and illumination with red or blue light at the diseased sites. Photosensitizers show the highest peak of absorption at about 405 nm, although a wavelength of about 635 nm is preferentially used for irradiation as light in the red part of the spectrum shows the best tissue penetration.1 Irradiated photosensitizers produce singlet oxygen, a highly reactive activated oxygen species and a major cytotoxin. The porphyrin precursor 5‐aminolaevulinic acid (ALA) or its methyl ester (methyl aminolaevulinate, so far the only approved formulation in Europe) is applied topically as photosensitizer to exclude systemic reactions. Possible light sources include lasers as well as incoherent light sources; irradiation with incoherent light sources is cheaper and more appropriate for large treatment areas. PDT appears to exert several favourable features for the treatment of localized skin diseases. Clinical conditions such as actinic keratoses, nodular and superficial basal cell carcinoma, skin tumours or precancerous lesions, Bowen disease, nonmalignant conditions such as acne vulgaris and leishmaniasis, as well as age‐related macular degeneration and ageing due to sun exposure have been treated with PDT.2, 3 The main advantages of PDT in comparison with other treatment modalities are its excellent cosmetic results and its high remission rates despite low invasiveness.3 Surprisingly, PDT has not been used in atopic dermatitis (AD) so far. In clinical practice patients with severe AD might be good candidates to receive a nontoxic treatment instead of local tacrolimus or systemic ciclosporin. We report an adult with AD, previously showing very severe localized disease, who responded favourably to PDT.
Evaluation of the time saved byprehospital initiation of reteplase forST-elevation myocardial infarction
Authors: David A Morrow, Elliott M Antman, Assaad Sayah, Kristin C Schuhwerk, Robert P Giugliano, James A deLemos, Michael Waller, Sidney A Cohen, Donald G Rosenberg, Sally S Cutler, Carolyn H McCabe, Ron M Walls, Eugene Braunwald
Journal: Journal of the American College of Cardiology (2002)
A Novel About Bioterrorism—Reply
Authors: Ketan Desai
Journal: JAMA (2001)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
FAS Inactivation Releases Unconventional Germinal Center B Cells that Escape Antigen Control and Drive IgE and Autoantibody Production
Authors: Danyal Butt, Tyani D. Chan, Katherine Bourne, Jana R. Hermes, Akira Nguyen, Aaron Statham, Lorraine A. O’Reilly, Andreas Strasser, Susan Price, Peter Schofield, Daniel Christ, Antony Basten, Cindy S. Ma, Stuart G. Tangye, Tri Giang Phan, V. Koneti Rao, Robert Brink
Journal: Immunity (2015)
Telomerase activity in peripheral blood mononuclear cells of psoriatic patients correlates with disease severity
Authors: X. Liu, J. Lin, L. Wang, Z. Zhang, S. Hou, G. Yang
Journal: British Journal of Dermatology (2007)

Journal Article Telomerase activity in peripheral blood mononuclear cells of psoriatic patients correlates with disease severity Get access X. Liu, X. Liu Department of Dermatology, The 1st Affiliated Hospital of Dalian Medical University, Dalian, China *Department of Dermatology, The Second People Hospital, Dalian, China E‐mail: lxm_1956@yahoo.com.cn Search for other works by this author on: Oxford Academic Google Scholar J. Lin, J. Lin Department of Dermatology, The 1st Affiliated Hospital of Dalian Medical University, Dalian, China *Department of Dermatology, The Second People Hospital, Dalian, China E‐mail: lxm_1956@yahoo.com.cn Search for other works by this author on: Oxford Academic Google Scholar L. Wang, L. Wang Department of Dermatology, The 1st Affiliated Hospital of Dalian Medical University, Dalian, China *Department of Dermatology, The Second People Hospital, Dalian, China E‐mail: lxm_1956@yahoo.com.cn Search for other works by this author on: Oxford Academic Google Scholar Z. Zhang, Z. Zhang Department of Dermatology, The 1st Affiliated Hospital of Dalian Medical University, Dalian, China *Department of Dermatology, The Second People Hospital, Dalian, China E‐mail: lxm_1956@yahoo.com.cn Search for other works by this author on: Oxford Academic Google Scholar S. Hou, S. Hou Department of Dermatology, The 1st Affiliated Hospital of Dalian Medical University, Dalian, China *Department of Dermatology, The Second People Hospital, Dalian, China E‐mail: lxm_1956@yahoo.com.cn Search for other works by this author on: Oxford Academic Google Scholar G. Yang G. Yang Department of Dermatology, The 1st Affiliated Hospital of Dalian Medical University, Dalian, China *Department of Dermatology, The Second People Hospital, Dalian, China E‐mail: lxm_1956@yahoo.com.cn Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 158, Issue 3, 1 March 2008, Pages 637–639, https://doi.org/10.1111/j.1365-2133.2007.08377.x Published: 01 March 2008
Noninvasive assessment of coronary flow velocity and coronary flow velocity reserve in the left anterior descending coronary artery by Doppler echocardiography
Authors: Takeshi Hozumi, Kiyoshi Yoshida, Takashi Akasaka, Yoshio Asami, Yumiko Ogata, Tsutomu Takagi, Shuichiro Kaji, Takahiro Kawamoto, Yoshiaki Ueda, Shigefumi Morioka
Journal: Journal of the American College of Cardiology (1998)
Abstract 1833: Relationship of Left Atrial Enlargement to Persistence or Development of Electrocardiographic Left Ventricular Hypertrophy in Hypertensive Patients: Implications for the Development of New Atrial Fibrillation
Authors: Peter M Okin, Eva Gerdts, Kristian Wachtell, Lasse Oikarinen, Markku S Nieminen, Bjorn Dahlof, Richard B Devereux
Journal: Circulation (2006)
Murine autoimmune hemolytic anemia resulting from Fc gamma receptor- mediated erythrophagocytosis: protection by erythropoietin but not by interleukin-3, and aggravation by granulocyte-macrophage colony- stimulating factor
Authors: T Berney, T Shibata, R Merino, Y Chicheportiche, V Kindler, P Vassalli, S Izui
Journal: Blood (1992)
Increased risk of psoriasis following chronic rhinosinusitis without nasal polyps: a population-based matched-cohort study
Authors: J.J. Keller, C.-S. Wu, H.-C. Lin
Journal: British Journal of Dermatology (2012)

Although chronic rhinosinusitis without nasal polyps (CRSsNP) and psoriasis both share immunological disturbances as pathological factors, no prior study has investigated the risk for psoriasis among patients with CRSsNP.To investigate the subsequent risk for psoriasis following a diagnosis of CRSsNP by utilizing a cohort study design and a population-based dataset in Taiwan.In total, 13 242 subjects with CRSsNP were included in the study cohort and 39 726 subjects were randomly extracted for the comparison cohort. We individually tracked each individual in this study (n = 52 968) for a 5-year period following their index date to identify those subjects who received a subsequent diagnosis of psoriasis. Cox proportional hazards regression analysis was conducted to calculate the 5-year risk of subsequent psoriasis following a diagnosis of CRS among the sampled subjects.The incidence rate of psoriasis during the 5-year follow-up period was 1·41 [95% confidence interval (CI) 1·14-1·71] per 1000 person-years and 0·69 (95% CI 0·59-0·81) per 1000 person-years for the study and comparison cohort, respectively. Stratified Cox proportional hazards regression revealed that the hazard ratio for psoriasis during the 5-year follow-up period for subjects with CRSsNP compared with the control group was 2·01 (95% CI 1·54-2·62) after adjusting for monthly income, geographical region, hypertension, diabetes, coronary heart disease and hyperlipidaemia, and censoring the cases who died during the 5-year follow-up period.This study detected an increased risk for psoriasis among patients with CRSsNP.
Dermoscopic features of acral lentiginous melanoma in a large series of 110 cases in a white population
Authors: A. Phan, S. Dalle, S. Touzet, S. Ronger-Savlé, B. Balme, L. Thomas
Journal: British Journal of Dermatology (2009)

Acral lentiginous melanoma (ALM) is a rare but distinctive subtype of melanoma. The diagnosis is often delayed and misdiagnosis is common, due to frequently unusual clinical presentation and a higher rate of amelanosis than in other melanoma subtypes.We aimed to investigate the dermoscopic features of a large series of ALM in a white-skinned population, in order to emphasize their diagnostic value.All recorded dermoscopic photographs of ALM, including nail unit variants, were collected from the files of the University Hospital Department of Dermatology (Lyons, France) and reviewed.In total 110 lesions, including 66 (60%) palmoplantar ALM and 44 (40%) ALM of the nail apparatus, were analysed for dermoscopic characteristics. The mean Breslow thickness was 2.6 mm. In volar skin melanomas, the two most prevalent patterns were irregular diffuse pigmentation (60%) and the parallel-ridge pattern (53%). Minor dermoscopic patterns, commonly noted in benign lesions, were also detected but only focally within the lesions. Among the 44 nail unit lesions, 31 (70%) presented irregular lines with variegations in colours, spacing, width and disruption of parallelism. Two cases of melanonychia striata had a triangular shape. Both corresponded to early ungual ALM. Association with subungual haemorrhage was not uncommon. The study included 37 (34%) amelanotic melanomas. However, dermoscopy enabled detection of microscopic remnants of pigmentation in most cases. The vascular pattern found in almost half of these lesions was polymorphous, with combinations of milky-red areas (95%), linear irregular vessels (49%), dotted vessels (43%) and hairpin vessels (41%).The presence of a parallel-ridge pattern and/or irregular diffuse pigmentation within the lesion is highly indicative of melanoma on volar skin. An irregular lines pattern is the most prominent dermoscopic feature of pigmented ALM of the nail apparatus. Amelanotic ALM either in volar skin or in nail apparatus is characterized by remnants of pigmentation and a polymorphic vascular pattern.
Abstract 14925: Inverse Association between Family History of Premature Coronary Artery Disease and the Risk of Death in Patients with Coronary Artery Disease
Authors: Ahmed Abdi Ali, Abdel Aziz Shaheen, Danielle A Southern, Mei Zhang, Merril Knudston, James White, Matthew James, Stephen B Wilton
Journal: Circulation (2014)

Background: Family history (FHx) of premature coronary artery disease (CAD) is an established cardiovascular risk factor. However the impact of FHx on outcomes of patients with CAD is unclear. Methods &amp; Results: The Alberta Provincial Project for Outcomes Assessment in Coronary Heart Disease (APPROACH) Program is an inclusive prospective registry of patients undergoing coronary angiography. Between April 2002 and Mar 2013, 99,667 patients were enrolled. 30,030 (30%) patients reported FHx, defined as a first degree relative with premature CAD (males &lt;55, females &lt;65 years). We investigated the association between FHx and all-cause mortality at 1 year, using multivariable logistic regression, adjusting for clinical characteristics, comorbidities, and the extent of CAD. Patients with normal angiography (15.2%) were excluded. Compared to those without FHx, those with FHx were younger (60.1 vs 64.0 years, p&lt;0.0001), more likely female (30.5% vs 29.5%; p=0.0018), and were less likely to have previously diagnosed CAD, congestive heart failure, stroke, or chronic kidney disease (all p&lt;0.0001) Conversely, those with FHx were more likely current smokers (31.8% vs 25.3%) and to have hypertension (68.8% vs 65.5%) and dyslipidemia (75.7% vs 68.1%), all p&lt;0.0001). The indication for angiography was an acute coronary syndrome (ACS) in 55% of both groups (p=0.57), and the extent of CAD was similar. Overall, FHx was associated with reduced 1-year mortality in fully adjusted models (odds ratio [OR] 0.56, 95% CI 0.51 to 0.62). This protective association was present in patients with and without a previous CAD event (OR 0.66 [95% CI 0.60 to 0.78] vs 0.53 [95% CI 0.47 to 0.59], respectively), and in patients with and without an ACS (OR 0.56 [95% CI 0.50 to 0.63] vs 0.56 [95% CI 0.48 to 0.65], respectively). There was slight attenuation of association with age, but FHx remained protective even in those aged 80 or more (OR 0.72, 95% CI 0.57 to 0.90). Conclusion: In patients with angiographic CAD, a family history of premature CAD is associated with lower mortality, independent of clinical characteristics, mode of presentation, and extent of disease. Further investigation of potential patient- and system-level mediators of this seemingly paradoxical relationship is required.
Abstract 3014: Pharmacologically Preconditioned MSCs Induce Myocardial Angiogenesis, Resuscitate Myocardial Integrity and Reduce Ventricular Remodeling in the Infarcted Rat Myocardium
Authors: Debayon Paul, Samson Mathews Samuel, Sataporn Muang-In, Mahesh Thirunavukkarasu, Lijun Zhan, Nilanjana Maulik
Journal: Circulation (2009)

Mounting evidence supports the therapeutic potential of mesenchymal stem cells (MSC) in the repair and resuscitation of scarred myocardium during IHDs. However, apprehensions exist with respect to ...
The course of transient hypochondriasis
Authors: A J Barsky, P D Cleary, M K Sarnie, G L Klerman
Journal: American Journal of Psychiatry (1993)

This study examined the longitudinal course of patients known to have had a previous episode of transient hypochondriasis.Twenty-two transiently hypochondriacal patients and 24 nonhypochondriacal patients from the same general medical clinic were reexamined after an average of 22 months with the use of self-report questionnaires, structured diagnostic interviews, and medical record review.The hypochondriacal patients continued to manifest significantly more hypochondriacal symptoms, more somatization, and more psychopathological symptoms at follow-up. They also reported significantly more amplification of bodily sensations and more functional disability and utilized more medical care. These differences persisted after control for differences in medical morbidity and marital status. Only one hypochondriacal patient, however, had a DSM-III-R diagnosis of hypochondriasis at follow-up. Multivariate analyses revealed that the only significant predictors of hypochondriacal symptoms at follow-up were hypochondriacal symptoms and the tendency to amplify bodily sensations at the baseline evaluation.Hypochondriacal symptoms appear to have some temporal stability: patients who experienced hypochondriacal episodes at the beginning of the study were significantly more hypochondriacal 2 years later than comparison patients. They were not, however, any more likely to develop DSM-III-R-defined hypochondriasis. Thus, hypochondriacal symptoms may be distinct from the axis I disorder. The data are also compatible with the hypothesis that preexisting amplification of bodily sensations is an important predictor of subsequent hypochondriacal symptoms.
Infection and preterm delivery
Authors: P. Brocklehurst
Journal: BMJ (1999)

Preterm delivery is defined as delivery before the 37th completed week of pregnancy, and in 1996in Scotland 84% of neonatal deaths of normally formed infants were associated with preterm delivery.1 The aetiology of preterm delivery is poorly understood, though recent evidence suggests that infection may be implicated in a substantial proportion of cases.2 The part that infection plays in the development of preterm labour or preterm, pre-labour rupture of membranes leading to preterm delivery has been the focus of much research in recent years.

One element of this work has been the finding of a strong association between the presence of bacterial vaginosis and preterm delivery. Bacterial vaginosis is a common infection of the female genital tract, caused by heavy concentrations of a mixed group of organisms, including Gardnerella vaginalis , Mycoplasma hominis , and anaerobes including curved rods and Mobiluncus species. Many of these organisms are present in small numbers in the vagina normally. Symptomatic infection is characterised by a grey vaginal discharge with a …