LIVER FUNCTION TESTS IN NONSPECIFIC ARTHRITIS WITH SPECIAL REFERENCE TO HYPERGLOBULINEMIA
Authors: B H ARCHER
Journal: Annals of Internal Medicine (1951)

Article1 May 1951LIVER FUNCTION TESTS IN NONSPECIFIC ARTHRITIS WITH SPECIAL REFERENCE TO HYPERGLOBULINEMIABENJAMIN H. ARCHER, M.D.BENJAMIN H. ARCHER, M.D.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-34-5-1173 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptFor years some students of arthritis have tried to connect rheumatoid arthritis with some vague hepatic deficiency, perhaps a hepatic dysfunction in the nature of a failure of the detoxifying function of the liver. But the idea has not been susceptible of proof, since no significant pathologic lesion in the liver has been noted,1 and since a few studies with different tests of hepatic function have shown no consistent hepatic insufficiency.2While other investigators3have used a variety of liver function tests in rheumatoid arthritis, only a few reports4are available on results with the cephalin-cholesterol flocculation and the thymol...Bibliography1. RosenbergBaggenstossHench EFAHPS: The cause of death in thirty cases of rheumatoid arthritis, Ann. Int. Med. 20: 903, 1944. LinkGoogle Scholar2. HenchBauerDawsonHallHolbrookKeyMcEwen PSWHLPJHC: The problem of rheumatism and arthritis (Sixth Rheumatism Review), Ann. Int. Med. 13: 1837, 1940. LinkGoogle Scholar3a. RawlsWeissCollins WBSVL: Liver function in rheumatoid arthritis, Ann. Int. Med. 10: 1021, 1937. Ibid. Ann. Int. Med. 12: 1455, 1939. b. Hepburn, J. S., Warter, P. J., and Rosenstein, G.: Liver function in arthritis measured by the hippuric acid test, Rev. Gastroenterol. 10: 126, 1943. c. Davis, J. S., Jr.: Protein studies in arthritis, J. Lab. and Clin. Med. 21: 478, 1936. d. Perlman, G. E., and Kaufman, D.: Electrophoretic distribution of proteins in serum, plasma and synovial fluid of patients with rheumatoid arthritis, J. Clin. Investigation 25: 931, 1946. LinkGoogle Scholar4a. CarterMaclagen HBNF: Some observations on the liver function tests in diseases not primarily hepatic, Brit. M. J. 2: 80, 1946. b. Kunkel, H. G.: Value and limitations of the thymol turbidity test as an index of liver disease, Am. J. Med. 4: 201, 1948. CrossrefGoogle Scholar5a. Archer BH: Clinical and biochemical study of remissions in chronic nonspecific arthritis, Arch. Int. Med. 84: 361, 1949. b. Archer, B. H.: The correlation of anti-rheumatic drugs and other therapeutic agents with liver damage. To be published. CrossrefGoogle Scholar6. Archer BH: A mixed form of chronic arthritis, M. J. and Rec. 134: 344, 1931. Google Scholar7. CecilArcher RLBH: Classification and treatment of chronic arthritis, J. A. M. A. 87: 741, 1926. CrossrefGoogle Scholar8. Hanger FM: The serological differentiation of obstructive from hepatogenous jaundice by flocculation of cephalin-cholesterol emulsions, J. Clin. Investigation 18: 261, 1939. CrossrefMedlineGoogle Scholar9. KibrickClements ACAB: A comparative study of the serum albumin and globulin ratios, the cephalin-cholesterol flocculation and the thymol turbidity tests for liver function, J. Lab. and Clin. Med. 30: 665, 1948. Google Scholar10. ShankHoagland RECL: A modified method for the quantitative determination of the thymol turbidity reaction of serum, J. Biol. Chem. 162: 133, 1946. CrossrefMedlineGoogle Scholar11. Maclagen NF: The thymol turbidity as an indicator of liver dysfunction, Brit. J. Exper. Path. 25: 234, 1944. Google Scholar12. Kingsley GR: The direct biuret method for the determination of serum protein, as applied to photoelectric and visual colorimetry, J. Lab. and Clin. Med. 27: 840, 1942. Google Scholar13. Howe PE: The use of sodium sulfate as globulin precipitant in determination of protein of blood, J. Biol. Chem. 49: 109, 1921. CrossrefGoogle Scholar14a. Loeb RF: Plasma proteins in health and disease, New England J. Med. 224: 980, 1941. b. Cantarow, A., and Trumper, M.: Clinical biochemistry, 1945, W. B. Saunders and Co., Philadelphia, p. 76. c. Todd, J. C., and Sanford, A. H.: Clinical diagnosis by laboratory methods, 1943, W. B. Saunders & Co., Philadelphia, p. 848. d. Bray, W. E.: Synopsis of clinical laboratory methods, 1944, C. V. Mosby & Co., St. Louis, p. 497. e. Lichtman, S. S.: Diseases of the liver, 1949, Lea & Febiger, Philadelphia, p. 284. CrossrefGoogle Scholar15a. Loeb .14a b. Gray, S. J., and Barron, E. S. G.: The electrophoretic analyses of the serum protein in disease of the liver, J. Clin. Investigation 22: 181, 1943. Google Scholar16. Duncan GG: Diseases of metabolism, 1947, W. B. Saunders & Co., Philadelphia, p. 111. Google Scholar17a. GrayBarron .15b b. Lichtman, 14e p. 284. Google Scholar18. CantarowTrumper ,14b p. 94. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: *Received for publication November 4, 1949.From the Medical Service and the Pathological Laboratories of the Bronx Hospital. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byLiver Function Tests in Rheumatoid ArthritisOn Some Liver Functions in Rheumatoid ArthritisOn Some Liver Functions in Rheumatoid ArthritisASSOCIATION OF HASHIMOTO'S THYROIDITIS AND RHEUMATOID ARTHRITISThe FII agglutinating factors in serums of patients with non-rheumatic diseasesSome current concepts of the etiology of rheumatoid arthritisRHEUMATISM AND ARTHRITIS REVIEW OF AMERICAN AND ENGLISH LITERATURE OF RECENT YEARS (ELEVENTH RHEUMATISM REVIEW)* Part IIWILLIAM D. ROBINSON, M.D., F.A.C.P., JOSEPH J. BUNIM, M.D., F.A.C.P., WILLIAM S. CLARK, M.D., DARRELL C. CRAIN, M.D., F.A.C.P., EPHRAIM P. ENGLEMAN, M.D., F.A.C.P., DONALD C. GRAHAM, M.D., F.R.C.P. (C), MAX M. MONTGOMERY, M.D., F.A.C.P., BERNARD M. NORCROSS, M.D., F.A.C.P., CHARLES RAGAN, M.D., F.A.C.P., MARIAN W. ROPES, M.D., F.A.C.P., EDWARD F. ROSENBERG, M.D., F.A.C.P., CHARLEY J. SMYTH, M.D., F.A.C.P.THE CLINICAL SIGNIFICANCE OF HYPERGLOBULINEMIA. II. CORRELATION WITH LIVER FUNCTION TESTS, SEROLOGIC TESTS FOR SYPHILIS, AND BONE MARROW EXAMINATIONS*ALVAN R. FEINSTEIN, M.D., ROBERT G. PETERSDORF, M.D.Liver Function Tests in Rheumatoid ArthritisThe Liver in Rheumatoid ArthritisAetiology and pathogenesis of rheumatoid arthritisWeitere Untesuchungen �ber die Dysprotein�mie beim Rheumatismus verus und verwandten Krankheiten 1 May 1951Volume 34, Issue 5Page: 1173-1178KeywordsAcute liver failureArthritisHyperglobulinemiaLesionsLiverLiver function testsMedical servicesRheumatoid arthritis Issue Published: 1 May 1951 PDF downloadLoading ...