tbuckley/cabot-search huggingface dataset:
Abstract 1811: Evaluation of anti-CXCR2 small molecule inhibitors as novel chemotherapy targeting the Interleukin-8 pathway in colorectal cancer
Authors: Yinghui Jane E. Huang, Kevin J. Gaffney, Ethan Gerdts, Nicos A. Petasis, Heinz-Josef Lenz, Melissa J. LaBonte
Journal: Cancer Research (2014)

Abstract Despite new and improved chemotherapy treatments for colorectal cancer (CRC) contributing to enhanced treatment response rates and patient prognosis, it has been suggested that an overwhelming 90% of metastatic CRC patients encounter treatment failure due to drug resistance. The Interleukin-8/CXCR2 pathway has been validated as a promising target for novel chemotherapy due to its overarching effects on various cell types within the tumor microenvironment that ultimately drive tumor growth, proliferation, survival, chemoresistance, metastasis and angiogenesis. A series of homologous small molecule inhibitors, which competitively bind to the active site of CXCR2, was developed and evaluated in terms of their efficacy in inhibiting the various cellular responses induced by IL-8/CXCR2 signaling, utilizing MTS cell proliferation, angiogenesis tube formation, colony formation, Western blot, cell migration and invasion assays. The anti-CXCR2 compounds developed produce potent repression of proliferation and colony forming capacity in HCT116, HT29, SW620 and LoVo CRC cell lines, achieving IC50 values as low as 9.6 μM in HCT116 and 9.6 μM in HT29, along with colony formation fold changes as low as .163 in HCT116 and .255 in HT29. Additionally, the compounds demonstrated inhibition of angiogenesis, migration and invasion and induced significant down-regulation of pathways downstream of CXCR2, including NF-κB, MAPK and Akt. The proposed targeting of the IL-8 pathway offers an attractive and promising approach to CRC therapy. Based on the structure and functional relationship of these compounds, new inhibitors will be designed and validated in hopes of having improved drug properties by utilizing our in vitro and in vivo assay systems. Citation Format: Yinghui Jane E. Huang, Kevin J. Gaffney, Ethan Gerdts, Nicos A. Petasis, Heinz-Josef Lenz, Melissa J. LaBonte. Evaluation of anti-CXCR2 small molecule inhibitors as novel chemotherapy targeting the Interleukin-8 pathway in colorectal cancer. [abstract]. In: Proceedings of the 105th Annual Meeting of the American Association for Cancer Research; 2014 Apr 5-9; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2014;74(19 Suppl):Abstract nr 1811. doi:10.1158/1538-7445.AM2014-1811
Abstract 13741: Increased HbA1c Level is Independently Associated With the Severity of Coronary Artery Diseases
Authors: Anping Cai, Jiyan Chen, Yingling Zhou, Yujin Mo, Xida Li, Xuebiao Wei, Liwen Li
Journal: Circulation (2014)

Objective:  To evaluate the relationship between glycosylated hemoglobin (HbA1c) level and the severity of atherosclerotic cardiovascular diseases (CVD).   Method:  Totally 573 participants were enrolled from April of 2013 to May of 2014 and all subjects were underwent coronary angiography (CAG) for evaluating the number of coronary artery stenosis. According to clinical presentation, electrocardiography, cardiac biomarker, and CAG result, all participants were divided into control group (excluded CVD), stable angina group (SA), unstable angina group (UA) and acute myocardial infarction (AMI) group. One-way ANOVA, multivariate analysis and logistic regression analysis were performed to evaluate the relationship between HbA1c level and the severity of atherosclerotic cardiovascular diseases.   Results:  Values of HbA1c in the control, SA, UA and AMI groups were 6.05 ± 1.17 %, 6.49 ± 1.37 %, 6.53 ±1.20 %, and 6.98 ± 2.09 % respectively (P for trend = 0.001). After adjusted for age, gender, family history of CAD, smoking, hypertension, fasting blood glucose, LDL-C and uric acid, HbA1c level was still independently associated with the severity of CAD, with odd ratio of 1.621 (AMI group versus control group, 95 % confidence interval 1.196-2.198, P = 0.002). Additionally, the relationship between HbA1c level and the number of coronary artery stenosis was also assessed. Values of HbA1c in the control group, single-vessel stenosis group, and multiple-vessels stenoses group were 6.01 ± 1.04 %, 6.23 ± 1.22 %, and 6.74 ± 1.46 % respectively (P for trend    Conclusion:  Increased HbA1c level was independently associated with the severity of coronary artery diseases and by which mechanism needs further investigation.
Abstract P087: Cardiometabolic Risk Factors and Socioeconomic Status in Peruvian Adults: The CRONICAS Cohort Study
Authors: Renato Quispe, Juan C Bazo-Alvarez, Frank Peralta-Alvarez, Giancarlo A Valle, William Checkley, Robert H Gilman, Liam Smeeth, Antonio Bernabé-Ortiz, J. J Miranda
Journal: Circulation (2015)

The association between cardiovascular diseases (CVD) and social determinants remains complex and varies between and within countries. The distribution of CVD risk factors by socioeconomic status (SES) determines the health inequality arising across nations and within countries, but it urges a better understanding of how social determinants affect health in LMIC. We sought to estimate the association between SES indicators and cardiometabolic risk factors in Peruvian population.  Pooled data, from four distinct geographical sites, from the age- and sex-stratified population-based CRONICAS Cohort study was analyzed. SES indicators were wealth index (in tertiles), educational attainment (highest level of education) and place of residence (urban or rural). Outcomes were diabetes (fasting glucose ≥126mg/dL or current medication), hypertension (SBP ≥140 or DBP ≥90mmHg, or antihypertensive medication), obesity (BMI ≥30kg/m2), high total cholesterol (≥200mg/dL), low HDL-c: (  Rural place of residence had a negative association with all cardiometabolic risk factors studied. These results highlight the need to contextualize risk factors by socioeconomic groups in countries in transition.
Abstract 18679: A Novel Volumetric Index of Left Ventricular Sphericity Independently Predicts Appropriate ICD Therapy
Authors: Jason Matos, Yehoshua C Levine, Warren J Manning, Alfred E Buxton
Journal: Circulation (2014)

Introduction: Adverse left ventricular (LV) remodeling plays an important role in arrhythmogenesis of patients with abnormal systolic function, but it is unknown if noninvasive parameters associated with adverse remodeling predict arrhythmias in the real-world population. In this retrospective study, we sought to determine if a novel echocardiographic index of LV remodeling would predict appropriate implantable cardioverter-defibrillator (ICD) therapy in patients who received primary prevention ICDs with and without cardiac resynchronization therapy (CRT-D).

Methods: We determined the sphericity index (SI), the ratio of biplane LV end-diastolic volume to apical 4-chamber LV end-diastolic length, and examined its association with appropriate ICD therapy for ventricular arrhythmias in primary prevention patients receiving ICDs between 2006 and 2010.

Results: We studied 278 subjects (203 - conventional ICD, 75 - CRT-D). Median follow-up (f/u) was 2.0 and 2.1 years, respectively. Appropriate ICD therapy occurred in 28 (18.7%) of the patients with ICDs and 15 (20.0%) of the patients with CRT-Ds. Median time to first appropriate ICD therapy was significantly shorter in patients with SI in the upper vs. lower 50% of values (1.43 vs. 2.40 years, p=0.01 for the ICD cohort; 1.54 vs. 2.63 years, p=0.04 for the CRT-D cohort). In multivariable Cox regression analysis, an SI in the upper 50% (>2.61 ml/mm for the ICD cohort; >2.65 ml/mm for the CRT-D cohort) was a strong independent predictor of appropriate ICD therapy after adjustment for gender, age, New York Heart Association functional class, LV ejection fraction, BUN, and atrial fibrillation (adjusted Hazard Ratio [HR] 2.0, p=0.03 for the ICD cohort; adjusted HR 5.4, p=0.015 for the CRT-D cohort). An SI in the upper 50% was not associated with total mortality in either cohort.

Conclusions: Echocardiographic SI predicts appropriate ICD therapy, but not total mortality, in patients with primary prevention ICDs. Prospective study of SI is warranted to confirm its clinical value for risk stratifying patients.
Abstract 4104: Obesity and colon cancer: Does time of exposure matter
Authors: Jinyu Xu, Jennifer Thomas-Ahner, Samantha DeMarsh, Steven K. Clinton, Susan E. Olivo-Marston
Journal: Cancer Research (2014)

Abstract Purposes: Obesity is associated with an increased risk of colon cancer in many epidemiology studies, while calorie restriction (CR) has shown protective effects on colon tumorigenesis in animal studies. This preclinical study was designed to investigate the long-term impacts of early exposure to high fat diet or CR diet on colon tumorigenesis. Methods: 50 three-week-old female C57/B6J mice were assigned into five groups: 1) control; 2) HF-control; 3) control-HF; 4) HF and 5) CR-control. Mice were initially placed on a control diet (10% kcal from fat), HF diet (45% kcal from fat), or 30% CR diet and fed ad libitum for nine weeks from the time of weaning and followed by a seven-week control diet. Azoxymethane was injected once a week for five weeks at a dose of 10 mg/kg beginning at 13 weeks of age. At 18 week-old, mice were placed on either a control diet or a HF diet. Mice were euthanized at 46 week-old and colons were collected to assess tumorigenesis. Results: After nine weeks of diet intervention, the percentage of body fat was higher in the mice on the HF diet (31.9%) and lower in those on the CR diet (18.4%), compared to mice on the control diet (20.0%, p=0.08). Mice on a CR diet in early life had lower body weights at the endpoint, compared to those on the control diet (p=0.03). Analysis of colon histopathology is ongoing as well as evaluation of apoptosis and proliferation. Conclusions: Early life exposure to calorie restriction has long-term impacts on body weight. Early life exposure to high fat diet may increase the risk of colon tumorigenesis. This model is currently being used to investigate the effects of early alterations in energy balance on colon cancer development and underlying molecular mechanisms. Citation Format: Jinyu Xu, Jennifer Thomas-Ahner, Samantha DeMarsh, Steven K. Clinton, Susan E. Olivo-Marston. Obesity and colon cancer: Does time of exposure matter. [abstract]. In: Proceedings of the 105th Annual Meeting of the American Association for Cancer Research; 2014 Apr 5-9; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2014;74(19 Suppl):Abstract nr 4104. doi:10.1158/1538-7445.AM2014-4104
THE DURATION OF THE MYELOTOXIC EFFECTS OF CIRCULATING ALKYLATING AGENTS.
Authors: Adolph Ulfohn, Stanley P. Kramer, Howard Dorfman, Benjamin Witten, Charles Williamson, Samuel Sass, Jacob I. Miller, Arnold M. Seligman
Journal: Cancer Research (1964)

Summary  A technic has been devised to measure the active drug in circulating blood at various intervals after the intravenous injection of alkylating agents. The circulation to one hind leg (the protected leg) of a rabbit is blocked by tourniquet for varying periods of time during and after intravenous injection of an alkylating agent. After sacrifice of the rabbit (in 4 days) the bone marrows of the protected and unprotected legs are compared for changes in cellularity.  All the sulfur mustards tested, with the possible exception of S-170, disappeared rapidly from the circulation irrespective of their in vitro half-lives. Certain other alkylating agents such as bis-(1-aziridinyl)morpholinophosphine oxide and Sarcolysin did not follow this pattern. In these instances a toxic level was maintained in circulating blood for longer periods of time. The present study indicated that this technic may be useful for comparing agents with relatively long half-lives but not for comparison of agents with very short half-lives. It is probably more useful for predicting clinical behavior than is the in vitro half-life.
The ability of pro adrenomedullin to predict severe sepsis in patients with comunity-acquired pneumonia
Authors: Ane Uranga, Pedro Pablo España, Alberto Capelastegui, Inmaculada Gorordo, Rosa Diez, Amaia Bilbao, Carmen Mar, Edurne Bereciartua
Journal: European Respiratory Journal (2011)

Objective:  The aim of this study was to compare the ability that validated predictive rules (PSI and CURB65) and the new biomarker Pro adenomedullin (proADM), had to predict severe sepsis.   Methods:  We prospectively included patients over 18 years old for a period of one year. PSI and CURB65 scores were estimated to all of them on admission. Blood samples were collected at the time of diagnosis to determine proADM levels. Patients with septic shock were also included. The predictive accuracy of proADM, PSI or CURB65 to predict severe sepsis was determined by calculating the area under the ROC curve (AUC). AUC values were compared using the non-parametric method described by Hanley and NcNeil. Further, we also tested whether the inclusion of the biomarker improves the performance of the PSI or CURB65 risk scores by comparing the AUC values of the logistic regression models including the biomarker and PSI or CURB65 to the model including risk solely scores.   Results:  A total of 615 patients with CAP were included in our study. 320 (52.03%) were hospitalized and 295 (47.97%) were not. A group of 232 patients had severe sepsis of whom 15 had septic shock. The AUC for proADM to predict severe sepsis was 0.85. The AUC for PSI score was 0.87 and the one for the CURB65 score was 0.86. Once proADM was added to the PSI score or to the CURB65 score, the AUC for predicting severe sepsis was 0.89. In both cases p value was   Conclusion:  ProADM is an important parameter in the prediction of severe sepsis in patients with CAP. Indeed, adding this biomarker to validated predictive rules, improves the predictive accuracy for severe sepsis.
Abstract 2785: LYN is a new prognostic and therapeutic target in non-small cell lung cancer
Authors: Yu Jin Kim, Minjung Sung, Min Jeong Park, Young Kee Shin, Yoon-La Choi
Journal: Cancer Research (2014)

Abstract SRC family kinases (SFKs) have a strong rationale as a clinical strategy in non-small cell lung cancer (NSCLC). Unfortunately, the reviewed study showed disappointing activity of SFK inhibitor dasatinib in molecularly unselected patient cohort. Therefore, the studies in NSCLC should be investigated to identify patients more likely to benefit from dasatinib either as monotherapy or in combination with other agents. Here, we considered that LYN may play specific roles in lung cancer and therefore analysed survival prognosis according to the expression of LYN and the effect of dasatinib on the inhibition of cell growth and LYN activity. We evaluated LYN expression by immunohistochemistry on 446 NSCLCs using paraffin-embedded tissues. Elevated LYN expression level of NSCLCs, especially in adenocarcinoma, female, and non-smoker, affected poor overall survival (OS, P=0.036). In lung adenocarcinoma cell lines, LYN expression impacted on cell proliferation, migration and invasion. Dasatinib treatment resulted in decreased cell viability in most of these cell lines. Also, we found that dasatinib suppressed active tyrosine phosphorylation of LYN. In the resistant cell lines, H23 and SK-LU-1, which showed elevated epidermal growth factor (EGFR) and MET activities, combined treatment of EGFR or MET inhibitor with dasatinib revealed the synergistic effects on decreased cell viability. Our findings highly suggest that LYN has potential as a new selected target molecule of SFKs in the treatment of NSCLCs. Citation Format: Yu Jin Kim, Minjung Sung, Min Jeong Park, Young Kee Shin, Yoon-La Choi. LYN is a new prognostic and therapeutic target in non-small cell lung cancer. [abstract]. In: Proceedings of the 105th Annual Meeting of the American Association for Cancer Research; 2014 Apr 5-9; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2014;74(19 Suppl):Abstract nr 2785. doi:10.1158/1538-7445.AM2014-2785
TV: Some talk of genocide
Authors: T. Delamothe
Journal: BMJ (2000)

Paying the Price—The Killing of the Children of Iraq: A special report by John Pilger, ITV, Monday 6 March at 9 30 pm

Last month, the United Nations' top official in Iraq resigned, no longer able to tolerate the suffering caused by nine years of economic sanctions. In taking this action for these reasons, he followed in the footsteps of his immediate predecessor. A few days after his resignation, the head of the UN world food programme in Iraq also resigned in protest.

John Pilger's documentary, Paying the Price—The Killing of the Children of Iraq , showed why these people might want to distance themselves as far as possible from the policies of the UN Security Council towards Iraq. “Every UN agency dealing with health, food, agriculture, and children has reported repeatedly that tens of thousands of the most vulnerable in society have died or are suffering as a result of the sanctions,” says Pilger. “Why should the civilian population, including children born since the Gulf war, innocent people, be held hostage to the compliance of a dictator?”

The World Health Organization estimates that, …
Leitfaden der Pathologie und Therapie der Kampfgaserkrankungen
Authors: Otto Muntsch
Journal: JAMA (1934)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
SYPHILITIC HEART DISEASE PROBABLY DUE TO CONGENITAL SYPHILIS; REPORT OF TWO CASES
Authors: SOL KATZ, M.D., HUGH H. HUSSEY, M.D., F.A.C.P., BERNARD J. WALSH, M.D.
Journal: Annals of Internal Medicine (1945)

ExcerptIt is very difficult to establish the diagnosis of syphilitic aortitis in children and adolescents, and confirmation by pathological study is absolute only if the Treponema pallidum is found in the aorta. Stolkind1 emphasized that the Treponema pallidum is not found in the aorta of children with congenital syphilis who are more than one year old, and for this reason the diagnosis of congenital syphilitic aortitis has rarely been proved in older children or adolescents. McDonald2 has indicated that the aortic lesions of congenital syphilis differ in no way from those of the acquired form.The order of frequency with...
Treatment for trigeminal neuralgia
Authors: T. Nurmikko, J. Miles, P. Eldridge, D. Bowsher, J. Jessop, J. M Zakrzewska, A. J Sidebottom, J. C Cooper
Journal: BMJ (1997)

Doctors should work towards elimination of all firearms and knivesEditor-With the publication of the Cullen report into the shooting of several children at a school in Scotland 1 and the cross party support in parliament to increase the controls on handguns, the moment is ripe for the medical profession to pursue a new health campaign.Over the past three or four decades the profession has had some success in raising public awareness of the risks of cigarette smoking and through that, probably, in saving lives.The reduction of the suicide rate is an objective of the Health of the Nation for England, yet suicide rates are still rising among young men. 2 Homicide is a major political issue.Weapons, especially firearms and knives, contribute to both these forms of premature death.Elimination of all firearms and knives that are surplus to domestic and industrial requirements would not solve either problem entirely, but it would make an important contribution.We believe that the profession, through the BMA and one or two royal colleges (particularly the Royal College of Psychiatrists), could develop policies about weapons control.The prime minister has already indicated that he would introduce controls on knives if a workable definition for the surplus ones was drawn up.
Abstract 17600: Lipid Phosphate Phosphatase 3 Negatively Regulates Smooth Muscle Cell Phenotypic Modulation and Limits Neotimal Hyperplasia
Authors: Manikandan Panchatcharam, Sumitra Miriyala, Abdelghaffar Salous, Jessica Wheeler, Anping Dong, Manjula Sunkara, Diana Escalante-Alcalde, Andrew J Morris, Susan S Smyth
Journal: Circulation (2011)

Manikandan Panchatcharam, 2011 Finalist and Presenting Author
Global Collaboration to Develop New and Existing Drugs for Neonates
Authors: Jonathan M. Davis, Mark A. Turner
Journal: JAMA Pediatrics (2015)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Pediatrics HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Pediatrics journal
Kutanöz tip pemfigus vulgaris: Pemfigusun seyrek görülen bir klinik fenotipi
Authors: Kazue Yoshida, Yujiro Takae, Hitoshi Saito, Hiroshi Oka, Akiko Tanikawa, Masayuki Amagai veTakeji Nishikawa
Journal: Journal of the American Academy of Dermatology (2005)
Book: Traumatic Pasts: History, Psychiatry, and Trauma in the Modern Age, 1870-1930
Authors: S. Wessely
Journal: BMJ (2002)

A 2·5-ml injection of 1/1,000 solution of euflavine given down each vas during vasectomy for sterilization will destroy all sperms within the semen and eliminate the necessity for examining two consecutive specimens of semen for azoospermia after the operation. No local inflammatory response has been observed in the seminal vesicles or prostate of 81 consecutive patients in whom the method has been used.