tbuckley/cabot-search huggingface dataset:
Heart Rate Response to Exercise Stress Testing in Asymptomatic Women
Authors: Martha Gulati, Leslee J. Shaw, Ronald A. Thisted, Henry R. Black, C. Noel Bairey Merz, Morton F. Arnsdorf
Journal: Circulation (2010)

Background— The definition of a normal heart rate (HR) response to exercise stress testing in women is poorly understood, given that most studies describing a normative response were predominately based on male data. Measures of an attenuated HR response (chronotropic incompetence) and age-predicted HR have not been validated in asymptomatic women. We investigated the association between HR response to exercise testing and age with prognosis in 5437 asymptomatic women. Methods and Results— Participants underwent a symptom-limited maximal stress test in 1992. HR reserve (change in HR from rest to peak), chronotropic index, and age-predicted peak HR were calculated. Deaths were identified to December 31, 2008. Mean age at baseline was 52±11 years, with 549 deaths (10%) over 15.9±2.2 years. Mean peak HR was inversely associated with age; mean peak HR=206–0.88(age). After adjusting for exercise capacity and traditional cardiac risk factors, risk of death was reduced by 3% for every 1–beat-per-minute increase in peak HR, and by 2% for every 1–beat-per-minute increase in HR reserve ( P &lt;0.001). Inability to achieve 85% age-predicted HR was not an independent predictor of mortality, but being ≥1 SD below the mean predicted HR or a chronotropic index &lt;0.80 based on the prediction model established by this cohort were independent predictors of mortality ( P &lt;0.001 and P =0.023, respectively). Conclusions— Chronotropic incompetence is associated with an increased risk of death in asymptomatic women; however, the traditional male-based calculation overestimates the maximum HR for age in women. Sex-specific parameters of physiological HR response to exercise should be incorporated into clinical practice.
Unstrange minds Remapping the world of autism
Authors: Kathleen Koenig
Journal: Journal of Clinical Investigation (2007)

With incendiary dialogue dominating the discussion of autism these days, an enlightened perspective is truly welcome. In Unstrange minds, Roy Richard Grinker, an anthropologist and parent of a child with autism, offers that perspective. Grinker tackles the most controversial issues — etiology and epidemic — and describes his experience raising a daughter with autism. Moreover, Grinker presses the reader to understand autism as shaped by culture and the historical framework through which it’s been viewed over the past 50 years. Reading Unstrange minds couldn’t be a more timely exercise.
Endoscopic papillotomy and removal of gall stones.
Authors: M Classen, L Safrany
Journal: BMJ (1975)

Endoscopic papillotomy was attempted in 59 patients with extrahepatic obstruction of the biliary duct system and was actually performed in 50 patients. A special high-frequency diathermy knife was introduced via a duodenoscope into the terminal common bile duct and the roof of the papilla was incised. In 33 out of 39 patients with choledocholithiasis the stones passed into the duodenum spontaneously or were removed endoscopically. Papillary stenosis without ductal stones was successfully treated with this method in eight out of 11 patients. One perforation of the duodenocholedochal junction occurred and was repaired surgically. Endoscopic papillotomy and stone extraction is a relatively safe and effective method of treating extrahepatic jaundice.
Extrapyramidal signs should be sought more often in Alzheimer's disease
Authors: M. N Lowenthal
Journal: BMJ (1996)

EDITOR,—Yoav Ben-Shlomo and colleagues restate the rarity of the existence of the amyotrophic lateral sclerosis-parkinsonism-dementia complex in areas other than the Pacific focus.1 Colleagues and I have reported on a patient who had amyotrophic lateral sclerosis and dementia but in whom tremor was absent and the bradykinesia that was present was …
Epidermoid Cyst of the Terminal Phalanx of the Hand
Authors: Robert A. Hinrichs
Journal: JAMA (1965)

EPIDERMOID CYSTS of the bony skeleton of the hand and specifically of the phalanges have been periodically described since Sonntag's original report in 1923.<sup>1</sup>Less than 50 cases have been reported in the literature. As it is a comparatively uncommon entity, the addition of a new case and a brief review of the clinical features is considered pertinent. <h3>Report of a Case</h3> A 38-year-old married, oil company employee had crushed his middle three fingers between two pipes while at work on June 30, 1962. Initial treatment consisted of local cleansing and application of a topical ointment but without x-ray examination. The wounds apparently healed uneventfully, but subsequently, the middle-digit nail plate developed a longitudinal fissure and the fingertip was intermittently painful and swollen. Pain was aggravated even by light touch and became progressively worse in the six weeks prior to seeking medical attention on May 7, 1963. Past history
Pseudohyperparathyroidism Due to Stromal Cell Sarcoma of the Uterus
Authors: Roy C. Orlando
Journal: JAMA (1972)

<h3>To the Editor.—</h3> The clinical picture of hypercalcemia associated with malignant neoplasms without bone metastases and correction of the hypercalcemia by antitumor therapy has been called pseudohyperparathyroidism.<sup>1</sup>Although bronchogenic carcinoma and hypernephroma head the list of malignant neoplasms producing this syndrome, a large variety of tumors from other organs have been reported, including 14 gynecologic malignant neoplasms.<sup>2-4</sup>To our knowledge, this is the first report describing the syndrome in association with a stromal cell sarcoma of the uterus. <h3>Report of a Case.—</h3> A 62-year-old Negro woman was admitted to DCGH with painless swelling of the left lower extremity of two weeks' duration. She had also noted a recent increase in abdominal girth, a weight loss of 6.8 kg, and vaginal bleeding. There was no history of peptic ulcer, renal stones, mental disorders, bone pain, or drug or alkali ingestion. Positive findings on physical examination were a slightly enlarged
848 VIRAL KINETICS DURING TREATMENT WITH A CONTROLLED-RELEASE RECOMBINANT INTERFERON ALFA 2B IN GENOTYPE 1 CHRONIC HEPATITIS C PATIENTS
Authors: E. Herrmann, S. Zeuzem, I. Dzyublyk, L. Moroz, I. Zaytsev, S. Martens, E.J. van Hoogdalem, J.E. Humphries
Journal: Journal of Hepatology (2008)
Hypothesis testing in experimental and naturalistic memory research
Authors: Daniel B. Wright
Journal: Behavioral and Brain Sciences (1996)

Abstract Koriat &amp; Goldsmith's distinction between the correspondence and storehouse metaphors is valuable for both memory theory and methodology. It is questionable, however, whether this distinction underlies the heated debate about so called “everyday memory” research. The distinction between experimental and naturalistic methodologies better characterizes this debate. I compare these distinctions and discuss how the methodological distinction, between experimental and naturalistic designs, could give rise to different theoretical approaches.
A Diacylglycerol-Dependent Signaling Pathway Contributes to Regulation of Antibacterial Autophagy
Authors: Shahab Shahnazari, Wei-Lien Yen, Cheryl L. Birmingham, Jessica Shiu, Anton Namolovan, Yiyu T. Zheng, Keiko Nakayama, Daniel J. Klionsky, John H. Brumell
Journal: Cell Host & Microbe (2010)
[399] IMPAIRMENT OF MEMORY/EFFECTOR CELLS MATURATION MAY ACCOUNT FOR LACK OF VIRUS IMMUNE CONTROL IN PAEDIATRIC PATIENTS WITH HBV INFECTION
Authors: I. Carey, A. Giannattasio, S. Bansal, M.S. Longhi, F. Meda, Y. Ma, G. Mieli-Vergani, D. Vergani
Journal: Journal of Hepatology (2007)
111In WBC SPECT/CT Detection of a Radiographically Occult Solitary Infected Renal Cyst in Polycystic Kidney Disease
Authors: Matthew S. Guy, Arash Kardan
Journal: Clinical Nuclear Medicine (2015)

Renal cyst infection-pyocystis-is a potentially life-threatening complication of autosomal-dominant polycystic kidney disease. Differentiation of pyocystis from pyelonephritis is important for antibiotic management. A 56-year-old woman with autosomal-dominant polycystic kidney disease and recurrent urinary tract infections was admitted to the hospital with suspicion of pyelonephritis. CT and static planar In-labeled WBC examinations failed to show a specific focus of infection. Abdominal imaging with In-labeled WBC SPECT/CT revealed abnormal leukocyte accumulation within a solitary right renal cyst. Precise SPECT/CT localization of the infected renal cyst is illustrated along with comparative CT images.
Legal, decent, honest, and truthful
Authors: G. Langley
Journal: BMJ (1995)

Popeye, “strong to the finish, ‘cos he eats his spinach,” and Jack Sprat, who would eat no fat (and his wife would eat no lean), seem to have inspired the Meat and Livestock Commission's campaign Meat Matters, which is aimed at consumers, health professionals, and journalists.

One of the eye catching national advertisements compares the dietary iron contained in a huge tower of raw spinach on one plate and a grilled steak on the other. A great photo opportunity, but not quite the “rational” approach boasted by the commission. Although steak ranks highly among meats in iron content, spinach is not the front runner among plant sources. Indeed, Popeye might have done better to take a spoonful of black molasses since, gram for gram, molasses, cashew nuts, soya beans, wholemeal bread, and even popadums provide considerably more, and better absorbed, iron than does spinach.

A more equitable approach, although less visually striking, would have compared similar portions of cooked soya …
Thalidomide–dexamethasone as primary therapy for advanced multiple myeloma
Authors: Michael Wang, Donna M. Weber, Kay Delasalle, Raymond Alexanian
Journal: American Journal of Hematology (2005)

Abstract The value of thalidomide–dexamethasone was assessed in 26 consecutive, previously untreated patients with multiple myeloma of high tumor mass. All showed Hgb &lt; 8.5 g/dL, serum calcium &gt; 11.5 mg/dL, or both. The response rate was 73%, frequency of early death &lt; 3 months was 5%, projected median survival was 30 months, and projected median remission time was 25 months. There were no occurrences of grade 3 or 4 neutropenia or thrombocytopenia, so that serious infection occurred in only 12% of patients. Thalidomide–dexamethasone was useful for these patients with advanced disease because of the high response rate and acceptable survival, with a low frequency of serious complications. Am. J. Hematol. 79:194–197, 2005. © 2005 Wiley‐Liss, Inc.
Abstract 1664: A functional study of missense variants localized in the DNA binding domain of BRCA2
Authors: Lucia Guidugli, Vernon Shane Pankratz, Catherine A. Erding, David E. Goldgar, Fergus J. Couch
Journal: Cancer Research (2012)

Abstract Genetic evidence of pathogenicity is not available for most missense mutations (Variants of Uncertain Significance (VUS)) detected in the DNA binding domain (DBD) of BRCA2 by clinical genetic testing. In the absence of this evidence, functional assays may be useful for classification of the clinical relevance of these VUS. We used a cell based Homology-Directed repair reporter assay to characterize 14 known pathogenic and 18 known non-pathogenic BRCA2 missense mutations and 34 VUS from the DBD of BRCA2. We transfected each full-length wildtype and mutant BRCA2 construct into V-C8 BRCA2 deficient cells along with an I-Sce1-expression plasmid, which induces a unique double strand break in an integrated DR-GFP reporter plasmid. The protein expression levels were evaluated by immunoprecipitation and Western blotting. The ability of each BRCA2 mutant to repair the induced break was evaluated by fluorescent activated cell sorting (FACS) for GFP. The HDR assay exhibited 100% (95% CI: 75.3% - 100%) sensitivity and 100% (95% CI: 81.5% - 100%) specificity for pathogenic missense mutations. Next, we developed a statistical classifier for prediction of the pathogenicity or non-pathogenicity of BRCA2 variants based on results from the HDR assay. Using known pathogenic and non-pathogenic variants as standards we computed the probability that each variant is pathogenic or non-pathogenic based on HDR activity. A probability of 99% in favor of pathogenicity correctly classified the known pathogenic mutations and the non-pathogenic variants. The evaluation of an additional 34 variants identified 18 variants as deleterious and eight as neutral. In summary the HR assay serves as a reliable high-quality surrogate for classification of VUS located in the BRCA2 DBD. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 103rd Annual Meeting of the American Association for Cancer Research; 2012 Mar 31-Apr 4; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2012;72(8 Suppl):Abstract nr 1664. doi:1538-7445.AM2012-1664
Patient Care after Percutaneous Coronary Artery Interventions
Authors: Mark A. Marinella
Journal: Annals of Internal Medicine (1998)

Letters1 April 1998Patient Care after Percutaneous Coronary Artery InterventionsMark A. Marinella, MDMark A. Marinella, MDWright State University School of Medicine; Dayton, OH 45429Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-128-7-199804010-00017 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:As a general internist practicing hospital-based internal medicine, I found the recent article by O'Meara and Dehmer [1] informative and clinically applicable. As the authors point out, clinicians caring for patients who have recently undergone a percutaneous coronary procedure need to be alert for myriad potential complications. Some of these complications may involve the kidneys and lead to electrolyte derangements and acute renal failure. The authors note that therapy with certain drugs may need to be discontinued before the procedure to minimize the risk for renal injury. Drugs that are known to affect potassium homeostasis and may ...References1. O'Meara JJ, Dehmer GJ. Care of the patient and management of complications after percutaneous coronary artery interventions. Ann Intern Med. 1997; 127:458-71. Google Scholar2. Marinella MA. Hyperkalemia in elderly patients associated with trimethoprim-sulfamethoxazole. J Geriatr Drug Ther. 1996; 11:93-7. Google Scholar3. Mayo RR, Swartz RD. Redefining the incidence of clinically detectable atheroembolism. Am J Med. 1996; 100:524-9. Google Scholar4. Ramirez G, O'Neill WM, Lambert R, Bloomer HA. Cholesterol embolization: a complication of angiography. Arch Intern Med. 1978; 138:1430-2. Google Scholar5. Marinella MA. Cholesterol crystal embolism [Letter]. Lancet. 1996; 348:403-4. Google Scholar Author, Article, and Disclosure InformationAffiliations: Wright State University School of Medicine; Dayton, OH 45429 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 April 1998Volume 128, Issue 7Page: 598-599KeywordsCoronary arteriesDrug therapyDrugsHeparinHypercholesterolemiaKidneysPatientsPotassiumRenal failureStable coronary artery disease Issue Published: 1 April 1998 Copyright & PermissionsCopyright © 1998 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Metabolic tinkering by the gut microbiome
Authors: Joel Selkrig, Peiyan Wong, Xiaodong Zhang, Sven Pettersson
Journal: Gut Microbes (2014)

Brain development is an energy demanding process that relies heavily upon diet derived nutrients. Gut microbiota enhance the host's ability to extract otherwise inaccessible energy from the diet via fermentation of complex oligosaccharides in the colon. This nutrient yield is estimated to contribute up to 10% of the host's daily caloric requirement in humans and fluctuates in response to environmental variations. Research over the past decade has demonstrated a surprising role for the gut microbiome in normal brain development and function. In this review we postulate that perturbations in the gut microbial-derived nutrient supply, driven by environmental variation, profoundly impacts upon normal brain development and function.
Fetal subdural haemorrhages presenting as hydrocephalus.
Authors: M J Robinson, M D Cameron, M F Smith, A B Ayers
Journal: BMJ (1980)

the health care staff.Currently, however, the health equipment industry is against the concept of supplying sophisticated equipment to, for example, intensive care units or other nearbedside users who do not have technical support from laboratory doctors.Whether or not the industry does devise the necessarily foolproof ways of doing the more routine tests close to the patient, the performance of a laboratory will continue to be judged by the range and quality of the service it offers to the clinician in particular and to the community in general in diagnosing and preventing disease. References
252 Randomized controlled trial of PEGinterferon alfa-2A plus ribavirin for chronic hepatitis C virus-genotype 4 among Egyptian patients
Authors: F THAKEB, M OMAR, M AWADY, S ISSHAK
Journal: Hepatology (2003)

A major breakthrough in babesiosis vaccine research was achieved with the development of methods for continuous propagation in vitro of Babesia parasites. The development of a soluble, exoantigen-containing immunogen, free of erythrocytic antigens, has been proposed as a practical and realistic means of immunoprophylactic control of babesiosis. Such immunogens have been tested for immunogenicity of different strains, minimal protective dose, and protective efficacy of a combined B. bovis-B. bigemina immunogen. During the last 7 years, most of these aspects have been studied in a co-operative research programme between the University of Illinois and the Veterinary Research Institute of Venezuela. The Babesia exoantigen vaccine prevents clinical disease, is effective against different parasite strains, induces protective immunity for at least 13 months, does not immunize against host blood groups, is antigenically stable for at least 3 years at 4 °C, and is available in large quantities. Continued improvement of currently available culture-derived immunogens will best guarantee the successful production of food-producing animals in the tropics. Since July 1984, 16 field vaccination trials have been conducted in 7 states of Venezuela in areas where large-scale dairy and beef production is crucial for the livestock industry. These ranches encompassed a cattle production of 14 000, of which 3000 have been vaccinated with a combined B. bovis-B. bigemina immunogen in 2 subcutaneous inoculations with a 4-week interval. In the first 5 trials, a 1-year monitoring period following vaccination and natural tick exposure indicated that the culture-derived vaccine has effectively controlled the clinical manifestation of infection. Studies on antigen characterization are shifting the emphasis from crude antigenic preparations to purified polypeptides, isolated and identified using new biochemical techniques. Current research efforts are directed toward isolation of protective antigens and the production of synthetic vaccines. Until optimal molecular vaccines are developed, a polyvalent inactivated B. bovis-B. bigemina immunogen may offer the best combination of potency, efficacy and safety available for effective immunoprophylaxis against bovine babesiosis.
1111-225 In the rapid pacing canine model of heart failure, left ventricular stimulation resynchronizes better the left ventricle compared to biventricular or right ventricular stimulation: An echocardiographic-hemodynamic correlation of systolic and diastolic function
Authors: Bernard Thibault, Anique Ducharme, Yan-Fen Shi, Marc Dubuc, Peter Guerra, Laurent Macle, Denis Roy, Mario Talajic, Jean-Claude Tardif
Journal: Journal of the American College of Cardiology (2004)
NIDDM in Mexican-American Families: Heterogeneity by age of onset
Authors: Braxton D Mitchell, Candace M Kammerer, Laurie J Reinhart, Michael P Stern
Journal: Diabetes Care (1994)

OBJECTIVE Heredity has long been known as a risk factor for non-insulindependent diabetes mellitus (NIDDM), but the mode of inheritance of NIDDM remains unclear. We examined the distribution of diabetes in 29 Mexican-American families ascertained on a diabetic proband. RESEARCH DESIGN AND METHODS Probands represented a random sample of diabetic Mexican Americans residing in low-income neighborhoods from San Antonio, TX. A total of 375 family members of these diabetic probands were examined, and diabetes was diagnosed according to the World Health Organization lasma glucose criteria. RESULTS The prevalence of diabetes decreased from 28.2% in first-degree relatives of the probands to 13.3% in second-degree relatives to 11.1% in third-degree relatives. When compared with Mexican Americans with no parental history of diabetes, this represents an excess of diabetes of 2.0-, 1.3-, and 1.1-fold in first-, second-, and thirddegree relatives, respectively. Five of the 29 probands (17%) had an age of diabetes onset &amp;lt;40 years. In the first-degree relatives of these early-onset probands, diabetes prevalence was 47.0% (16 of 34) compared with only 24.1% (34 of 141) in the first-degree relatives of the 24 late-onset probands. After adjustment for age, this excess represented a fivefold increase in the odds of diabetes among relatives of the early-onset probands compared with relatives of the late-onset probands (P &amp;lt; 0.001). Moreover, the 16 affected family member of the early-onset probands had a mean age of diabetes onset of 42.7 years compared with 49.9 years for the 34 affected members of the late-onset probands, although this difference was not statistically significant (P = 0.13). CONCLUSIONS NIDDM may be genetically heterogeneous in this Mexican- American population, with family members of early-onset diabetes patients being at higher risk for NIDDM than family members of late-onset diabetes patients.
Treatment of Status Epilepticus
Authors: Walter P. Zmyslowski
Journal: JAMA (1976)

<h3>To the Editor.—</h3> As an anesthesiologist, I would like to comment on Dr Schneider's letter (235:1964,1976) and Dr Nicol's review (234:419, 1975) concerning the treatment of status epilepticus; mainly, initiating a trial of lidocaine (Xylocaine) hydrochloride intravenously before giving general anesthesia. I was consulted concerning a patient who was still having convulsions despite therapeutic doses of diazepam (Valium), phenobarbital, and phenytoin (Dilantin) sodium. A 30-mg bolus of lidocaine hydrochloride was given intravenously, with complete cessation of convulsions in less than a minute. There were no changes in cardiovascular or respiratory measurements. A lidocaine drip similar to that used for treatment of cardiac arrhythmias was prepared, but it was not needed, as convulsions did not recur. Resuscitative equipment and medication should be available when lidocaine is administered, because convulsions and cardiovascular collapse are possible adverse side effects. Lidocaine has been successfully used in the treatment of status epilepticus, as mentioned by
Zygomatic implants: indications, techniques and outcomes, and the Zygomatic Success Code
Authors: Carlos Aparicio, Carolina Manresa, Karen Francisco, Pedro Claros, Javier Alández, Oscar González‐Martín, Tomas Albrektsson
Journal: Periodontology 2000 (2014)

Abstract The zygoma implant has been an effective option in the management of the atrophic edentulous maxilla as well as for maxillectomy defects. Brånemark introduced the zygoma implant not only as a solution to obtain posterior maxillary anchorage but also to expedite the rehabilitation process. The zygoma implant is a therapeutic option that deserves consideration in the treatment‐planting process. This paper reviews the indications for zygoma implants and the surgical and prosthetic techniques (including new developments) and also reports on the clinical outcome of the zygomatic anatomy‐guided approach. An overview of conventional grafting procedures is also included. Finally, a Zygoma Success Code, describing specific criteria to score the success of rehabilitation anchored on zygomatic implants, is proposed.