THE CLINICAL AND METABOLIC EFFECTS OF PROGESTERONE AND ANHYDROHYDROXY-PROGESTERONE IN RHEUMATOID ARTHRITIS
Authors: L H KYLE, D C CRAIN
Journal: Annals of Internal Medicine (1950)

Article1 May 1950THE CLINICAL AND METABOLIC EFFECTS OF PROGESTERONE AND ANHYDROHYDROXY-PROGESTERONE IN RHEUMATOID ARTHRITISLAURENCE H. KYLE, M.D., DARRELL C. CRAIN, M.D., F.A.C.P.LAURENCE H. KYLE, M.D.Search for more papers by this author, DARRELL C. CRAIN, M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-32-5-878 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptDespite Hench's observation in 19331that improvement of the joint symptoms in rheumatoid arthritis commonly followed the occurrence of jaundice, practical application of this information met with but meager success.2, 3, 4Five years later, Hench added the significant observation that temporary remission of symptoms occurred frequently during pregnancy.5Until recently, this information, although repeatedly confirmed and thoroughly discussed, did little to advance the therapy of rheumatoid arthritis. Barsi6claimed effectiveness for transfusions of blood of pregnant women but it is the consensus at the present time that this form of therapy has little value.7Although a temporary remission of...Bibliography1. Hench PS: Analgesia accompanying hepatitis and jaundice in cases of chronic arthritis, fibrositis and sciatic pain, Proc. Staff Meet., Mayo Clin. 8: 430-436, 1933. Google Scholar2. Hench PS: Effect of jaundice on chronic infectious (atrophic) arthritis and on primary fibrositis, Arch. Int. Med. 61: 451-481, 1938. CrossrefGoogle Scholar3. ThompsonWyatt HEBL: Experimentally induced jaundice (hyperbilirubinemia), Arch. Int. Med. 61: 482-495, 1938. CrossrefGoogle Scholar4. GardnerStewartMacCallum FAFO: Therapeutic effect of induced jaundice in rheumatoid arthritis, Brit. Med. J. 2: 677-680, 1945. CrossrefMedlineGoogle Scholar5. Hench PS: The ameliorating effect of pregnancy on chronic atropic (infectious rheumatoid) arthritis, fibrositis, and intermittent hydroarthrosis, Proc. Staff Meet., Mayo Clin. 13: 161-167, 1938. Google Scholar6. Barsi I: A new treatment of rheumatoid arthritis, Brit. M. J. 2: 252-253, 1947. CrossrefMedlineGoogle Scholar7. Editorial: Transfusions of blood from pregnant women for rheumatoid arthritis, J. A. M. A. 139: 718, 1949. CrossrefGoogle Scholar8. Hughes W: Resistence in rheumatism, Ann. Rheumat. Dis. 3: 89-100, 1942. CrossrefMedlineGoogle Scholar9. Sjövall H: Die Hormonausscheidung bei chronischer Polyarthritis des Weibes, Acta med. Scandinav. 117: 69-88, 1944. Google Scholar10. CohenDubbsMyers AAWA: The treatment of atrophic arthritis with estrogenic substance, New England J. Med. 222: 140-142, 1940. CrossrefGoogle Scholar11. Freyberg RH: Treatment of arthritis with vitamin and endocrine preparations; emphasis of their limited value, J. A. M. A. 119: 1165-1171, 1942. CrossrefGoogle Scholar12. Dunn CW: Present status of endocrine therapy in arthritis, M. Clin. N. Am. 24: 1697-1708, 1940. CrossrefGoogle Scholar13. TouwKuipers JFRK: The treatment of affections of the joints with progestine, Acta med. Scandinav. 96: 501-508, 1938. CrossrefGoogle Scholar14. Leblond CP: Detoxification of progesterone derivatives in the liver, Am. J. M. Sc. 204: 566-567, 1942. CrossrefGoogle Scholar15. PearlmanCerceo WHE: The isolation of pregnanol-3 (gamma)-one, pregnanediol 3 (alpha), 20 (beta) and etiocholanediol-3 (gamma), 17 (beta) from the bile of pregnant cows, J. Biol. Chem. 176: 847-856, 1948. CrossrefMedlineGoogle Scholar16. HenchKendallSlocumbPolley PSECCHHF: The effect of a hormone of the adrenal cortex (17-hydroxy-11-dehydrocorticosterone) (Compound E) and of pituitary adrenocorticotropic hormone on rheumatoid arthritis. Preliminary report, Proc. Staff Meet., Mayo Clin. 24: 181-197, 1949. MedlineGoogle Scholar17. HamblenCuylerHirst ECWKDV: Urinary excretion of pregnanediol complex by males, Endocrinology 27: 172-176, 1940. CrossrefGoogle Scholar18. SchillerSmith SOW: Serum diastase and its relation to estrogen metabolism in pregnancy and the menstrual cycle, J. Clin. Endocrinology 3: 154-161, 1943. CrossrefGoogle Scholar19. AbelsDobriner JCK: Effect of progesterone on the nitrogen balance and on the circulating proteins of a normal man. Conference on Metabolic Aspects of Convalescence, Jos. Macy Jr. Found. 7: 121, 1944. Google Scholar20. AlbrightReifenstein FEC: The parathyroid glands and metabolic bone disease, 1948, The Williams & Wilkins Co., Baltimore, Md. Google Scholar21. Reich NE: The use of large doses of progesterone in rheumatoid arthritis, Am. Practitioner 4: 1-5, 1949. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Washington, D. C.*Received for publication November 18, 1949.From the Medical Service, Georgetown University Hospital and the Department of Medicine, Georgetown University School of Medicine.This study was aided in part by the William Wade Hinshaw Cancer Research Grant.We would like to express our gratitude to a number of the assistant medical residents who helped in this study, including Drs. Timothy F. O'Donovan, Clifton Gruver, August Bakos, Thomas O'Brien and John Stapleton. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byWirkungen der Gestagene auf den StoffwechselRheumatoid arthritis: A review of recent advances in our knowledge concerning pathology, diagnosis, and treatmentRHEUMATISM AND ARTHRITIS REVIEW OF AMERICAN AND ENGLISH LITERATURE OF RECENT YEARS (TENTH RHEUMATISM REVIEW)* Part IIWILLIAM D. ROBINSON, M.D., F.A.C.P., EDWARD W. BOLAND, M.D., F.A.C.P., JOSEPH J. BUNIM, M.D., F.A.C.P., DARRELL C. CRAIN, M.D., F.A.C.P., EPHRAIM P. ENGLEMAN, M.D., F.A.C.P., WALLACE GRAHAM, M.D., F.R.C.P. (C), L. MAXWELL LOCKIE, M.D., F.A.C.P., MAX M. MONTGOMERY, M.D., F.A.C.P., CHARLES RAGAN, M.D., F.A.C.P., MARIAN W. ROPES, M.D., F.A.C.P., EDWARD F. ROSENBERG, M.D., F.A.C.P., CHARLEY J. SMYTH, M.D.THE REVERSIBILITY OF CERTAIN RHEUMATIC AND NONRHEUMATIC CONDITIONS BY THE USE OF CORTISONE OR OF THE PITUITARY ADRENOCORTICOTROPIC HORMONE*PHILIP S. HENCH, M.D., F.A.C.P.The Modern Treatment of Rheumatoid Arthritis 1 May 1950Volume 32, Issue 5Page: 878-888KeywordsBlood transfusionGratitudeHospital medicineMedical servicesPregnancyProgesteroneResearch grantsRheumatoid arthritis ePublished: 1 December 2008 Issue Published: 1 May 1950 PDF downloadLoading ...