THERAPY WITH AMPHOTERICIN B IN NORTH AMERICAN BLASTOMYCOSIS
Authors: R S ABERNATHY, G T JANSEN
Journal: Annals of Internal Medicine (1960)

Article1 December 1960THERAPY WITH AMPHOTERICIN B IN NORTH AMERICAN BLASTOMYCOSISROBERT S. ABERNATHY, M.D., G. THOMAS JANSEN, M.D.ROBERT S. ABERNATHY, M.D.Search for more papers by this author, G. THOMAS JANSEN, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-53-6-1196 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe therapy of North American blastomycosis has not been completely satisfactory in the past. Although the aromatic diamidines, particularly stilbamidine and the less toxic 2-hydroxystilbamidine, have proved to be effective and distinctly more potent than potassium iodide, x-ray, or vaccine therapy, significant numbers of patients have been resistant to therapy, or have experienced recurrences of the disease despite large amounts of the diamidines given over long periods.7, 13Recent trials of amphotericin B2, 6, 7, 10, 11, 14have shown that it is an effective therapeutic agent for a variety of deep mycotic infections, including North American blastomycosis. Indeed, in...Bibliography1. BaumSchwarz GLJ: North American blastomycosis, Am. J. M. Sc. 238: 661 (Dec.) 1959. CrossrefGoogle Scholar2. BeardRichertTaylor HWJHRR: The treatment of deep mycotic infections with amphotericin B, with particular emphasis on drug toxicity, Am. Rev. Resp. Dis. 81: 43 (Jan.) 1960. CrossrefMedlineGoogle Scholar3. CarmodyTappen EJW: Blastomycosis meningitis: report of a case successfully treated with amphotericin B, Ann. Int. Med. 51: 780 (Oct.) 1959. LinkGoogle Scholar4. CurtisBocobo ACFC: North American blastomycosis, J. Chron. Dis. 5: 404 (Apr.) 1957. CrossrefMedlineGoogle Scholar5. DerbesKrafchuk VJJD: Response of North American blastomycosis to amphotericin B, Bull. Tulane M. Fac. 17: 157 (May) 1958. MedlineGoogle Scholar6. HarrellBocobo ERFC: Modern treatment of the systemic fungus diseases, Clin. Pharmacol. and Therap. 1: 104 (Jan.) 1960. CrossrefGoogle Scholar7. HarrellCurtis ERAC: North American blastomycosis, Am. J. Med. 27: 750 (Nov.) 1959. CrossrefGoogle Scholar8. Heiner DC: Diagnosis of histoplasmosis using precipitin reactions in agar gel, Pediatrics 22: 616 (Oct.) 1958. CrossrefMedlineGoogle Scholar9. LittmanHorowitzSwadey MLPLJG: Coccidioidomycosis and its treatment with amphotericin B, Am. J. Med. 24: 568 (Apr.) 1958. CrossrefMedlineGoogle Scholar10. NewcomerSternbergWrightReisner VDTHETRM: Current status of amphotericin B in the treatment of the systemic fungus infections, J. Chron. Dis. 9: 353 (Apr.) 1959. CrossrefMedlineGoogle Scholar11. SeaburyDascomb JHHE: Experience with amphotericin B for the treatment of systemic mycoses, Arch. Int. Med. 102: 960 (Dec.) 1958. CrossrefGoogle Scholar12. Smith DT: Immunologic types of blastomycosis: a report on 40 cases, Ann. Int. Med. 31: 463 (Sept.) 1949. LinkGoogle Scholar13. TakaroWalkupMatthews THEJH: The place of excisional surgery in the treatment of pulmonary mycotic infections, Dis. of Chest 36: 1 (July) 1959. MedlineGoogle Scholar14. UtzTreger JPA: The current status of chemotherapy of systemic fungal disease, Ann. Int. Med. 51: 1220 (Dec.) 1959. LinkGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Little Rock, Arkansas*Received for publication May 6, 1960.From the Departments of Medicine and Dermatology, University of Arkansas Medical Center, Little Rock, Arkansas.†Much of the amphotericin B was supplied as Fungizone by John T. Groel, M.D., Squibb Institute for Medical Research, New Brunswick, New Jersey.Requests for reprints should be addressed to Robert S. Abernathy, M.D., Associate Professor of Medicine, University of Arkansas Medical Center, Little Rock, Arkansas.‡Precipitin reactions were kindly done by D. C. Heiner, M.D., Department of Pediatrics, using his technic of double diffusion in agar.8 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byCase report: Blastomycosis causing sciatic neuritisBlastomycosis in children: A review of the literatureSystemic Mycoses—Primary Pathogenic FungiNorth American BlastomycosisNorth American BlastomycosisThe Treatment of Blastomycosis with Amphotericin BNorth American blastomycosisAmphotericin B Toxicity A Follow-up Report of 53 PatientsRAYMOND P. MILLER, M.D., JOSEPH H. BATES, M.D., F.A.C.P.Blastomycosis in childhood: treatment with amphotericin B and a review of the literatureEpidemiologic Studies of Blastomycosis in ArkansasAußereuropäische MykosenAußereuropäische MykosenRenal Tubular Acidosis Due to Amphotericin BResults of surgical and nonoperative treatment for pulmonary North American blastomycosisNephrotoxicity of Amphotericin B Early and Late Effects in 81 PatientsWILLIAM T. BUTLER, M.D., JOHN E. BENNETT, M.D., DAVID W. ALLING, M.D., PH.D., PAUL T. WERTLAKE, M.D., JOHN P. UTZ, M.D., GEORGE J. HILL II, M.D.The Use of Amphotericin B in Blastomycosis, Cryptococcosis and HistoplasmosisChemotherapeutic Agents for the Systemic MycosesMykosenExperiences in the Treatment of North American Blastomycosis with 2-HydroxystilbamidineWILLIAM R. LOCKWOOD, M.D., JOHN F. BUSEY, M.D., BLAIR E. BATSON, M.D., FRED ALLISON JR., M.D.An isolated blastomycetoma of the posterior cranial fossa treated successfully with surgery and amphotericin BAddison's Disease in North American Blastomycosis 1 December 1960Volume 53, Issue 6Page: 1196-1203KeywordsAmphotericinBlastomycosisDermatologyInfectious diseasesPediatricsPotassiumVaccines ePublished: 1 December 2008 Issue Published: 1 December 1960 PDF downloadLoading ...