tbuckley/cabot-search huggingface dataset:
Anaphylactic Reaction To γ-globulin
Authors: Elias R. Shemin
Journal: JAMA (1968)

<h3>To the Editor:—</h3> A 7-year-old white boy has been under my care for approximately 4 1/2 years, because of repeated upper-respiratory tract infections, and episodes of tonsilitis, somewhat helped by tonsillectomy at the age of 4. Additional complications have been nonspecific croup, bronchopneumonia, and superficial skin abscesses. Frequent and severe otitis media has usually been a consequence of an upper-respiratory tract infection. The boy would complain of pain in one ear in the morning, and, despite immediate administration of decongestants and antibiotics, perforation of the ear drum would take place in six to seven hours. This happened four or five times in four years, in addition to attacks of otitis media without perforation at least once a month. Otologic and other studies have reported only perennial nasopharyngitis of infectious origin. Cultures of nasopharyngeal and ear exudates have yielded<i>Haemophilus influenzae, Staphylococcus aureus</i>, coagulase positive, pneumococci, and streptococci of the<i>viridans</i>
EMCROs and the Evaluation of Medical Care
Authors: BEVERLY C. PAYNE
Journal: Annals of Internal Medicine (1975)

Editorials1 February 1975EMCROs and the Evaluation of Medical CareBEVERLY C. PAYNE, M.D., F.A.C.P.BEVERLY C. PAYNE, M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-82-2-276 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptNine Experimental Medical Care Review Organizations (EMCROs) were encouraged and funded by the National Center for Health Services Research in 1971. What was their mission, their purpose? The apparent answer was to prepare and demonstrate a rational method for evaluation of institutional medical care with attention to effective use of those institutions in maintaining or achieving an acceptable level of quality care within them. The nine EMCROs mounted parallel programs that combined health-services research and demonstrations based on available methodologies. All nine developed structurally similar criteria for evaluation of the medical diagnostic and therapeutic process. Each was properly concerned with...References1. WILLIAMSON J: Evaluating quality of patient care. A strategy relating outcome and process assessment. JAMA 218:564-569, 1971 CrossrefMedlineGoogle Scholar2. DECKERBONNER BP: Criteria in Peer Review. Cambridge, Massachusetts, Arthur D. Little, Inc., 1974 Google Scholar3. : Quality Assurance Program for Medical Care in the Hospital. Chicago, 1972 Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Kresge 1 Research Building University of Michigan Medical Building Ann Arbor, Michigan PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByProfessional productivity and quality assurance 1 February 1975Volume 82, Issue 2Page: 276-277KeywordsHealth care qualityHealth services research Issue Published: 1 February 1975 PDF DownloadLoading ...
Assessment of Fibrosis Progression in Untreated Irish Women With Chronic Hepatitis C Contracted From Immunoglobulin Anti-D
Authors: Robert A. Levine, Schuyler O. Sanderson, Robert Ploutz–Snyder, Frank Murray, Elaine Kay, John Hegarty, Niamh Nolan, Dermot Kelleher, George Mcdonald, J. Conor O’Keane, John Crowe
Journal: Clinical Gastroenterology and Hepatology (2006)
Ruptured popliteal cyst and pyogenic arthritis
Authors: J G Taylor
Journal: BMJ (1981)

Evidence from the Royal College of General Practitioners cohort study points to the progestogen dosage in combined preparations as being more important in this regard.'Moreover, a lack of association with oestrogen dosage was found.In addition, a positive correlation between the risk of arterial disease and progestogen dosage has been demon-strated3 and this, in part at least, may be due to the effect on blood pressure.
2007 Focused Update of the ACC/AHA 2004 Guidelines for the Management of Patients With ST-Elevation Myocardial Infarction
Authors: Elliott M. Antman, Paul W. Armstrong, Lee A. Green, Lakshmi K. Halasyamani, Judith S. Hochman, Harlan M. Krumholz, Gervasio A. Lamas, Sidney C. Smith, Mary Hand, Eric R. Bates, Charles J. Mullany, David L. Pearle, Michael A. Sloan
Journal: Journal of the American College of Cardiology (2008)
Clinical Notes of a Case of Malignant Disease of the Femur in which Amputation at the Hip-Joint was Successfully Performed
Authors: E. Watson
Journal: BMJ (1868)

THE completc recovery of a patient after such a severe and commonlyfatal operation as amputation at the hip-joint, is a very natural source of gratulation to the operator, and may fairly warrant his publication of' the case as an encouragement, and perhaps even, in some respects, as a guide, to other surgeons.I shall hope that my case may serve these good ends; but my chief object in relating it is to contribute something to the better understanding of the pathology of malignant disease of the; bones, a subject which, notwithstanding the valuable writings of Stanley, Paget, and others, must be considered as still surrounded with much
Flaunts and Flouts
Authors: William B. Bean
Journal: JAMA (1971)

<h3>To the Editor.—</h3> The use of "flaunt" for "flout" inThe Journal(<b>215</b>: 1481, 1971) reminded me of verses I wrote when, several years ago, the<i>Des Moines (Iowa)</i><i>Register</i>displayed a parade of pickets marching around the university in Iowa City. One banner carried by a fulltime marcher Walter Gormly read, "U. S. Army Flaunts Justice." This caused me to burst into verse: Oh Gormly, brother Gormly, You protest far too warmly. Most thoughtful people have grave doubts Of those who can't tell flaunts from flouts. Justice is what the Army wants And waves about, as you say, "flaunts." Men when they picket or parade Should watch how their displays are made Lest they reveal themselves as louts By flouting flaunts, not flaunting flouts. These crossovers along with militate-mitigate and affect-effect confusion lies just about at the borderline between human comprehensibility and the never-never land where control of language
Subcellular localization of coagulation factor II receptor-like 1 in neurons governs angiogenesis
Authors: Jean Sébastien Joyal, Satra Nim, Tang Zhu, Nicholas Sitaras, José Carlos Rivera, Zhuo Shao, Przemyslaw Sapieha, David Hamel, Melanie Sanchez, Karine Zaniolo, Manon St-Louis, Johanne Ouellette, Martin Montoya-Zavala, Alexandra Zabeida, Emilie Picard, Pierre Hardy, Vikrant Bhosle, Daya R. Varma, Fernand Gobeil, Christian Beauséjour, Christelle Boileau, William Klein, Morley Hollenberg, Alfredo Ribeiro-Da-Silva, Gregor Andelfinger, Sylvain Chemtob
Journal: Nature Medicine (2014)
A critical role for vesicle‐associated membrane protein‐7 in exocytosis from human eosinophils and neutrophils
Authors: M. R. Logan, P. Lacy, S. O. Odemuyiwa, M. Steward, F. Davoine, H. Kita, R. Moqbel
Journal: Allergy (2006)

Background: Granulocyte exocytosis is proposed to be critically dependent on the interaction of soluble N ‐ethylmaleimide‐sensitive factor attachment protein (SNAP) receptors (SNAREs) located on granules/vesicles (v‐SNAREs) and plasma membrane (t‐SNAREs). Previous studies indicated that the v‐SNARE, vesicle‐associated membrane protein (VAMP)‐2, as well as t‐SNAREs (SNAP‐23, syntaxin‐4 and ‐6) are implicated in exocytosis from human granulocytes. Vesicle‐associated membrane proteins‐7 and ‐8 have been implicated in endosome/lysosome trafficking, however, their role in granulocyte exocytosis remains obscure. Objective: We sought to investigate the expression and functional role of SNARE isoforms in the secretion of different granule‐derived mediators in human eosinophils and neutrophils. Methods: The expression of SNAREs was determined by subcellular fractionation and flow cytometry. SNARE‐specific antibodies were examined for their ability to impair mediator release from permeabilized eosinophils and neutrophils. Results: Vesicle‐associated membrane proteins‐7 and ‐8 were localized to granule and membrane‐enriched fractions in eosinophils and neutrophils, whereas syntaxin‐6 was not detectable. In permeabilized cells, anti‐VAMP‐7, but not anti‐VAMP‐8, antibody impaired the secretion of all mediators examined (in eosinophils, eosinophil peroxidase and eosinophil‐derived neurotoxin; in neutrophils, myeloperoxidase, lactoferrin and matrix metalloprotease‐9) in a dose‐dependent manner. In contrast, anti‐VAMP‐2 modestly and selectively impaired secretion from small granules and vesicles. Syntaxin‐4, but not syntaxin‐6, was found to interact with SNAP‐23 and was partially involved in mediator secretion from multiple compartments. Conclusion: Our observations indicate for the first time a critical role for VAMP‐7 in both eosinophil and neutrophil mediator release.
Mutations in KANSL1 cause the 17q21.31 microdeletion syndrome phenotype
Authors: Marcella Zollino, Daniela Orteschi, Marina Murdolo, Serena Lattante, Domenica Battaglia, Chiara Stefanini, Eugenio Mercuri, Pietro Chiurazzi, Giovanni Neri, Giuseppe Marangi
Journal: Nature Genetics (2012)
All India Institute staff is split over attempt to dismiss director
Authors: Ganapati Mudur
Journal: BMJ (2006)

An attempt by India's health minister to dismiss the director of the All India Institute of Medical Sciences in New Delhi has polarised its staff. The attempt comes amid charges of bad administration and countercharges of political interference at India's top teaching hospital.

The minister, Anbumani Ramadoss, who is also the president of the institute, last week moved at a meeting of the institute's governing body to dismiss the director, Panangipalli Venugopal, a cardiothoracic surgeon. The resolution was reportedly approved by a majority of the members present.

The move to dismiss the doctor …
800. Adenoviral Transduced Monocytes: Efficient Antigen Presenting Cells for the Activation of Antigen-Specific T Cells
Authors: Ann M. Leen, Maheshika K. Ratnayake, Aaron E. Foster, Cliona M. Rooney, Stephen Gottschalk
Journal: Molecular Therapy (2005)

Mature dendritic cells (DC) are potent antigen presenting cells (APC) that have been used in vaccine studies as well as adoptive immunotherapy protocols to activate antigen-specific cytotoxic T cells (CTL). However, the time and resources required for ex vivo DC generation has hampered the broader application of these therapeutic approaches. Here we describe a new method for the activation of antigen-specific T cells: it takes advantage of the tropism of Ad5F35 adenoviral vectors, which preferentially transduce monocytes after incubation of peripheral blood mononuclear cells (PBMC).
Steroid responsiveness in phaeochromocytoma.
Authors: P Daggett, S Franks
Journal: BMJ (1977)

In this case report of phaeochromocytoma the typical hypertensive crises were related to steroids. The patient was a 69-year-old woman with giant-cell arteritis which was confirmed histologically. 60 mg prednisone daily produced rapid  improvement. The erythrocyte sedimentation rate returned to normal.  Later when taking 5 mg of prednisone daily forceful palpitations and generalized tremors lasting 15 minutes occurred on 3 occasions. There were no more for 3 months. Prednisone was withdrawn. Within 2 weeks severe headaches had returned and  her erythrocyte sedimentation rate was 80 mm in 1 hour. 45 mg prednisone quickly relieved these symptoms but palpitation and tremors returned in 3 days and blood pressure was 240/140 mm Hg;  when prednisone was reduced to 5 mg daily attacks almost ceased and blood pressure returned to normal. High levels of urinary vanillylmandelic acid and of plasma catecholamines confirmed the diagnosis of phaeochromocytoma. By intravenous  pyelography the tumor was located. Premedication for removing a large right adrenal tumor included parenteral hydrocortisone and again the blood pressure was high. Blood pressure was controlled by an infusion of sodium nitroprusside and the  tumor was removed. After surgery the blood pressure was about 170/100 mm of Hg despite large doses of steroids. There were no further hypertensive episodes. Maintenance steroid treatment was continued. After removal of the tumor steroids had  no hypertensive effect. It is concluded that steroids should be given only with care in patients with a phaeochromocytoma.
General practitioners and child health preventive services.
Authors: H. Stein, A. E. Fairey, J. M. Mulholland, M. C. Lewis
Journal: BMJ (1989)

General medicine 8 5 9 0 8-3 7-2 General surgery 3-6 4-4 5.3 5-5 Geriatrics 11 2 12-2 7 5 9-7 Paediatrics 9-9 4-5 8-3 5-6 Ear, nose, and throat 2-8 3-7 4-4 Gynaecology 5 3 3-0 4 5 5 6 Traumaandorthopaedics 3-0 4-0 5 0 2-0 Thames region.The 28 day readmission rates by specialty for the financial year April 1987 to March 1988 are given in the table.Obviously the quality of data, the effects of random variation, and variations in case mix and severity will affect district rates, but the similari- ties between rates are of interest.It should be remembered, however, that the Oxford figures are based on nearly 20 years' data with evidence of increase over that period, and they do not include any data after 1985.Dr Henderson and colleagues suggest that readmission rate might be used as a performance indicator or indicator of outcome.Drawing on hospitalisation and hospital utilisation findings,2 I supply side variability might be one of the strongest determinants of readmission rate.Its sensitivity and specificity as a measure of outcome at a district level require further elaboration, although there is a clear role in medical audit for analysis of case notes of individual patients who have been readmitted.
THE EFFECTS UPON THE SKIN OF CONCENTRATED ULTRA-VIOLET LIGHT, AND ITS USE IN DERMATOLOGICAL THERAPY.*
Authors: SVEND LOMHOLT
Journal: British Journal of Dermatology (1931)

Journal Article THE EFFECTS UPON THE SKIN OF CONCENTRATED ULTRA‐VIOLET LIGHT, AND ITS USE IN DERMATOLOGICAL THERAPY. Get access SVEND LOMHOLT, O.B.E., M.D. SVEND LOMHOLT, O.B.E., M.D. Director of Research Laboratories, Finsen Institute, Copenhagen Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology and Syphilis, Volume 43, Issue 8-9, 1 August 1931, Pages 385–399, https://doi.org/10.1111/j.1365-2133.1931.tb09521.x Published: 01 August 1931
Paying for bmj.com: Move is a sensible surprise
Authors: C. Porter
Journal: BMJ (2003)

Editor—Ironically, I saw Delamothe and Smith's announcement about paying for access to bmj.com when double checking the URL of the BMJ while writing a sentence in my MA dissertation: “Some journals, such as the British Medical Journal, are currently available free online to the general public.”1

This sentence, however, refers to access for health professionals in developing countries. I therefore congratulate and admire the decision to keep free access for lower and middle income countries while collecting from those more able to pay.

My only concern is that the BMJ Publishing Group may not be charging enough to sustain its services, cover the administrative costs of collecting subscription fees, and still be able to support services such as INASP-Health (International Network for the Availability of Scientific Publications).
Novel idiotypic and antigen-binding characteristics in two anti-dinitrophenyl monoclonal antibodies.
Authors: N H Sigal
Journal: The Journal of Experimental Medicine (1977)

Monoclonal anti-dinitrophenyl antibodies generated in the splenic focus system from B cells of adult BALB/c mice were studied for the presence or absence of murine anti-T15 (M anti-T15) reactivity and for their ability to bind phosphorylcholine (PC). Two foci of the 680 clones analyzed bound PC, and one of these antibodies reacted with M anti-T15 and anti-Fab on a 1:1 weight basis. The discovery of a clonotype reactive with M anti-15 but not with rabbit anti-T15 (R anti-T15) serum, the converse of the R anti-T15+, M anti-T15- clonotype identified in the PC-specific repertoire, points to the novel idiotypic relationships which may be found among homogeneous antibodies binding diverse antigens. The R anti-T15-, M anti-T15+ clonotype may represent a distinct set of hypervariable region sequences inserted into the T15 framework or may be a somatic variant of the T15 germ-line sequence. In addition, the maximum frequency with which this clonotype occurs within the B-cell pool is estimated.
Appropriate Use of Carotid Endarterectomy
Authors: Mark R. Chassin
Journal: New England Journal of Medicine (1998)

The use of carotid endarterectomy is on the rise again. After a six-year decline, the number of such operations rose by 94 percent between 1991 and 1996. As shown in Figure 1, however, this has happened before: between 1980 and 1985, the incidence rose by 95 percent. The initial enthusiasm for the procedure was dampened by reports of high complication rates, questions about the appropriateness of patients selected to undergo the procedure, and the absence of rigorous clinical studies demonstrating the efficacy of the operation. What followed was a remarkable feat in research. A series of large and complex randomized, controlled . . .
Oxygenation Targets and Outcomes in Premature Infants
Authors: Eduardo Bancalari, Nelson Claure
Journal: JAMA (2013)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The Epidemiology of Diabetes in Pregnant Native Canadians: A risk profile
Authors: Stewart B Harris, Laura E Caulfield, Mark E Sugamori, Elaine A Whalen, Beth Henning
Journal: Diabetes Care (1997)

The purpose of this study was to determine the prevalence of diabetes in pregnancy (gestational diabetes mellitus [GDM] and NIDDM) and to identify risk factors in the development of GDM in a native population in northwestern Ontario, Canada.A retrospective analysis of 1,305 singleton deliveries among Ojibwa-Cree women from northwestern Ontario, Canada, was conducted from 1990 to 1993 inclusive. GDM was diagnosed using a 3-h oral glucose tolerance test (OGTT) and defined according to standard guidelines.The overall prevalence of diabetes in pregnancy (NIDDM and GDM) was 11.6% (152 of 1,305) with a GDM prevalence of 8.4% (110 of 1,305). Among 741 women with complete data, prevalence rates increased with age, peaking at 46.9% in the age-group > or = 35 years. Significant risk factors for GDM included older maternal age, multiparity, prepregnancy obesity, a family history of diabetes, and a history of GDM in previous pregnancies.Diabetes in pregnancy among Ojibwa-Cree reported here represent the highest rates reported to date in a Canadian population. The high rates of maternal obesity and relative young age of this population further highlight the urgent need for diabetes screening and prevention in this population.
A Fatal Reaction to Sulfobromophthalein
Authors: Sanford R. Mallin
Journal: JAMA (1960)

Widespread clinical use of the sulfobromophthalein (Bromsulphalein [BSP]) test since its introduction by Rosenthal in 1924<sup>1</sup>has confirmed the efficacy of this procedure as an index of hepatic parenchymal function. Less commonly appreciated are the hazards associated with the administration of the sulfobromophthalein dye. Of greatest importance is the rare, but frequently fatal, anaphylactoid reaction. This communication will summarize the serious reactions to sulfobromophthalein thus far reported and present the fifth known case of a fatal reaction. This represents the second reported case in which administration of sulfobromophthalein for the first time caused a fatal anaphylactoid reaction. <h3>Report of a Case</h3> This patient was a 41-year-old woman admitted to Hahnemann Hospital in 1959 with a chief complaint of epigastric and upper abdominal distress. She had noted upper abdominal fulness and bloating for six months, accompanied by eructations, nausea, and occasional vomiting. The symptoms were persistent and aggravated by most
Abstract LB-344: Emergence of carcinoma resistance to EGFR blockade via an integrin avb3/RalB/NFkB signaling axis
Authors: Laetitia J. Seguin, Ainhoa Mielgo, Miller Huang, Fernanda Camargo Camargo, Jacqueline Lesperance, Sara M. Weis, Jay S. Desgrosellier, David A. Cheresh
Journal: Cancer Research (2012)

Abstract EGFR inhibitors have been used to treat several cancers including pancreatic, breast, lung and colorectal cancers. However, resistance to EGFR inhibitors has emerged as a significant clinical problem. KRAS activation in cancer has been associated with tumor cell resistance to EGFR inhibition. Here we identify integrin αvβ3 as a marker for tumors that are resistant to EGFR blockade. In addition, we find that tumor cells initially lacking or expressing low levels of integrin αvβ3 specifically upregulate this integrin upon treatment with EGFR inhibitors. Surprisingly, αvβ3, even in the unligated state, interacts with and promotes a specific KRAS ependent function leading to the EGFR independent growth of various tumors. Specifically, αvβ3 promotes KRAS dependent activation of RalB and its downstream effectors TBK1/NFkB and Src leading to tumor growth in the presence of EGFR inhibitors. Accordingly, knockdown of RalB sensitizes αvβ3-expressing tumors to EGFR blockade while expression of an active RalB mutant promotes resistance of αvβ3 negative tumor cells to EGFR blockade. These findings reveal a new role for integrin αvβ3 in mediating tumor cell resistance to EGFR inhibition through activation of a specific KRAS dependent function. Our findings suggest a new way to circumvent EGFR resistance of a wide range of cancers by targeting the αvβ3/KRAS signaling pathway and its downstream effectors. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 103rd Annual Meeting of the American Association for Cancer Research; 2012 Mar 31-Apr 4; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2012;72(8 Suppl):Abstract nr LB-344. doi:1538-7445.AM2012-LB-344
Recombinant human DNase in management of lobar atelectasis due to retained secretions.
Authors: B A Touleimat, C S Conoscenti, J M Fine
Journal: Thorax (1995)

Recombinant human deoxyribonuclease (rhDNase) is an agent which reduces the viscoelasticity of purulent sputum. Two cases are reported in which rhDNase was utilised for the management of lobar atelectasis due to retained purulent secretions.