LEUKOCYTOSIS AND THE SYMPATHETICO-ADRENAL SYSTEM
Authors: F. B. Clare, C. H. Cress, E. Gellhorn
Journal: Annals of Internal Medicine (1944)

Article1 October 1944LEUKOCYTOSIS AND THE SYMPATHETICO-ADRENAL SYSTEMF. B. CLARE, C. H. CRESS, E. GELLHORNF. B. CLARESearch for more papers by this author, C. H. CRESSSearch for more papers by this author, E. GELLHORNSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-21-4-653 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptAlthough leukocytosis has often been linked with the excitation of autonomic centers and the secretion of epinephrine (Müller,1Hoff2) actual proof for this mechanism is rather inadequate. Walterhöfer3showed that injection of epinephrine was followed by a neutrophilic leukocytosis which he attributed to the action of epinephrine on the bone marrow (cf. also Schön4). Borchardt5likewise observed leukocytosis after epinephrine, but the physiological evaluation of these experiments is doubtful since this effect occurs only after administration of large doses of epinephrine and since similar effects may be obtained also after the injection of parasympathetic stimulants such as pilocarpin and choline....Bibliography1. MÜLLER EF: Evidence of nervous control of leucocytic activity by the involuntary nervous system, Arch. Int. Med., 1926, xxxvii, 268-280. CrossrefGoogle Scholar2. HOFF F: Blut und vegetative Regulation, Ergebn. d. inn. Med. u. Kinderh., 1928, xxxiii, 195-265. CrossrefGoogle Scholar3. WALTERHÖFER G: Die Veränderungen des weissen Blutbildes nach Adrenalininjektionen, Deutsch. Arch. f. klin. Med., 1921, cxxxv, 208-223. Google Scholar4. SCHÖN R: Über den Mechanism der Adrenalinwirkung aufs Knochenmark, Arch. f. exper. Path. u. Pharmakol., 1925, cvi, 78-88. Google Scholar5. BORCHARDT W: Zur Physiologie des Fiebers, Arch. f. exper. Path. u. Pharmakol., 1928, cxxxvii, 45-70. CrossrefGoogle Scholar6. GOTCH H, Cited after HOFF, F.: Japanische Beiträge zum Problem der zentralnervösen Blutregulation, Klin. Wchnschr., 1938, xvii, 638-640. Google Scholar7. HOFF F: Japanische Beiträge zum Problem der zentralnervösen Blutregulation, Klin. Wchnschr., 1938, xvii, 638-640. CrossrefGoogle Scholar8. BEER AG: Experimentelle Untersuchungen über die Leukocytenregulation, Klin. Wchnschr., 1938, xvii, 1397. Google Scholar9. ROSENOW G: Leucocytosis induced by injection of kaolin into cisterna and ventricles of the brain, Proc. Soc. Exper. Biol. and Med., 1941, xlvi, 5-9. Hirnstichleukocytose-Untersuchungen über die zentral-vegetative Blutregulation, Ztschr. f. d. ges. exper. Med., 1929, lxiv, 452-461. CrossrefGoogle Scholar10. FOAROIZIN PL: Influenza del sistema nervoso centrale sulla composizione morfologica del sangue, Arch. di fisiol., 1935, xxxv, 170-195. Google Scholar11. HARLOWSELYE CMH: The blood picture in the alarm reaction, Proc. Soc. Exper. Biol. and Med., 1937, xxxvi, 141-144. CrossrefGoogle Scholar12. GELLHORNFELDMAN EJ: The influence of cold and heat on the vago-insulin and the sympathetico-adrenal systems, Am. Jr. Physiol., 1941, cxxxiii, 670-675. CrossrefGoogle Scholar13. FELDMANCORTELLGELLHORN JRE: On the vago-insulin and sympathetico-adrenal systems and their mutual relationship under conditions of central excitation induced by anoxia and convulsant drugs, Am. Jr. Physiol., 1940, cxxxi, 281-289. On the vago-insulin and sympathetico-adrenal systems and their mutual relationship. II. Reaction to bulbocapnine and cocaine, Proc. Soc. Exper. Biol. and Med., 1941, xlvi, 157-160. CrossrefGoogle Scholar14. KESSLERGELLHORN ME: The effect of electrically induced convulsions on the vago-insulin and sympathetico-adrenal system, Proc. Soc. Exper. Biol. and Med., 1941, xlvi, 64-66. CrossrefGoogle Scholar15. FELDMANGELLHORN JE: The influence of fever on the vago-insulin and sympathetico-adrenal systems, Endocrinology, 1941, xxix, 141-143. CrossrefGoogle Scholar16. FARRISCRESKOFFFITZ-HUGH EJAJT: Hematology of the rat. The Rat, 1942, J. B. Lippincott Co., Philadelphia. Google Scholar17. LOWBLAUROCKKAPLANSHERMAN AAMFMI: Metrazol shock treatment of the "functional" psychoses, Arch. Neurol. and Psychiat., 1938, xxxix, 717-736. CrossrefGoogle Scholar18. HORN W: Weisses Blutbild und Krampfbehandlung, Psychiat.-neurol. Wchnschr., 1939, xli, 513-515. Google Scholar19. CLARECRESSGELLHORN FBCHE: Effect of various forms of anoxia and of conditions causing excitation of sympathetic centers on leucocytosis, Federation Proc., 1943, ii, 7. Google Scholar20. MILHORATSMALLDIETHELM ATSMO: Leucocytosis during various emotional states, Arch. Neurol. and Psychiat., 1942, xlvii, 779-792. CrossrefGoogle Scholar21. MORAAMTMANHOFFMAN JMLESJ: Effect of mental and emotional states on the leucocyte count, Jr. Am. Med. Assoc., 1926, lxxxvi, 945-946. CrossrefGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Chicago, Illinois*Received for publication September 7, 1943.Aided by a grant from the Josiah Macy, Jr. Foundation.†Present address: Univ. of Minnesota, Minneapolis, Minn. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byThe Mammalian ReticulocyteAsphyxie, sympathico-adrenales und vago-insul�res System und die Phagozytose der LeukozytenEvidence of Adreno-Cortical Stimulation by Autohemotherapy*The Rôle of the Hypophyseal-hypothalamic System in the Pathogenesis of Erythraemia and Symptomatic Polycythaemias. 1 October 1944Volume 21, Issue 4Page: 653-661KeywordsBone marrowEpinephrineLeukocytosis ePublished: 1 December 2008 Issue Published: 1 October 1944 PDF downloadLoading ...