Treatment of Cytomegalovirus Pneumonia with 9-[2-Hydroxy-1-(Hydroxymethyl) ethoxymethyl] Guanine and High-Dose Corticosteroids
Authors: ELIZABETH C. REED
Journal: Annals of Internal Medicine (1986)

Brief Report1 August 1986Treatment of Cytomegalovirus Pneumonia with 9-[2-Hydroxy-1-(Hydroxymethyl) ethoxymethyl] Guanine and High-Dose CorticosteroidsELIZABETH C. REED, M.D., PAULA S. DANDLIKER, M.S.N., JOEL D. MEYERS, M.D.ELIZABETH C. REED, M.D.Search for more papers by this author, PAULA S. DANDLIKER, M.S.N.Search for more papers by this author, JOEL D. MEYERS, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-105-2-214 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptEffective treatment for cytomegalovirus pneumonia, a major cause of mortality in marrow transplant patients, remains elusive. A new acyclic nucleoside, 9-[2-hydroxy-1-(hydroxy methyl) ethoxy methyl] guanine (DHPG; BW B759U, Burroughs-Wellcome, Research Triangle Park, North Carolina) has been shown to have both in-vitro and in-vivo activity against cytomegalovirus but did not improve survival when used to treat cytomegalovirus pneumonia in marrow transplant recipients, although it caused a significant reduction in the amount of virus in lung tissue (1). Because the progressive pulmonary failure may have resulted from a persistent inflammatory response in the lung induced by the virus, we used DHPG combined...References1. SHEPPDANDLIKERDE MIRANDA DPP. Activity of 9-[2-hydroxy-1-(hydroxymethyl)ethoxymethyl]guanine in the treatment of cytomegalovirus pneumonia. Ann Intern Med. 1985;103:368-73. LinkGoogle Scholar2. MASURLANEPALESTINE HHA. Effect of 9-(1,3-dihydroxy-2-propoxymethyl)guanine on serious cytomegalovirus disease in eight immunosuppressed homosexual men. Ann Intern Med. 1986;104:41-4. LinkGoogle Scholar3. . Treatment of serious cytomegalovirus infections with 9-(1,3-dihydroxy-2-propoxymethyl)guanine in patients with AIDS and other immunodeficiencies. N Engl J Med. 1986;314:801-5. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Fred Hutchinson Cancer Research Center University of Washington School of Medicine Seattle, Washington PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByGuidelines for the management of cytomegalovirus infection in patients with haematological malignancies and after stem cell transplantation from the 2017 European Conference on Infections in Leukaemia (ECIL 7)Relationship of Ganciclovir Therapeutic Drug Monitoring with Clinical Efficacy and Patient SafetyViral Infections in Patients with Hematological MalignanciesViral Infections in Patients with Hematological MalignanciesCYTOMEGALOVIRUSTherapeutic effect of a traditional Chinese medicine, ren-shen-yang-rong-tang (Japanese name: Ninjin'yoeito) on nitric oxide-mediated lung injury in a mouse infected with murine cytomegalovirusManagement of Viral Infections in Bone Marrow Transplant RecipientsSummary of the international consensus symposium on advances in the diagnosis, treatment and prophylaxis of cytomegalovirus infectionCytomegalovirus Prophylaxis and Treatment following Bone Marrow TransplantationProphylaxis of cytomegalovirus infection in bone marrow transplant patientsValue of laboratory investigations in clinical suspicion of cytomegalovirus-induced upper gastrointestinal tract ulcerations in HIV-infected patientsCYTOMEGALOVIRUS INFECTION IN THE BONE MARROW TRANSPLANT RECIPIENTCytomegalovirus Infection in Marrow TransplantationViral infections in severely immunocompromised cancer patientsSpecial Considerations for the Patient Undergoing Allogeneic or Autologous Bone Marrow Transplantation(±)-7-deazaaristeromycin lacking the hydroxymethyl substituentCytomegalovirus Infection in Bone Marrow TransplantationThe Control of Cytomegalovirus Infection: ChemotherapyTreatment and Prophylaxis of Cytomegalovirus Infection After Bone Marrow TransplantationHerpes Virus Infections in Immunocompromised Patients: Problems and Therapeutic InterventionsSystemic antiviral drugs used in ophthalmologyAntiviral AgentsEarly Treatment with Ganciclovir to Prevent Cytomegalovirus Disease after Allogeneic Bone Marrow TransplantationBiological Agents in Infectious DiseasesSuccessful Management of CMV Pneumonia in a Mechanically Ventilated PatientDiagnosis of cytomegalovirus pneumonitis on bronchoalveolar lavage fluid: Comparison of cytology, immunofluorescence, and in situ hybridization with viral isolationA Randomized, Controlled Trial of Prophylactic Ganciclovir for Cytomegalovirus Pulmonary Infection in Recipients of Allogeneic Bone Marrow TransplantsAntiviral effect of antileukemic drugs N4-Behenoyl-1-β-D-Arabinofuranosylcytosine (BH-AC) and 2,2′-Anhydro-1-β-D-Arabinofuranosylcytosine (Cyclo-C) Against Human CytomegalovirusImmune Recovery After Bone Marrow TransplantationGanciclovir for the Treatment of Cytomegalovirus Gastroenteritis in Bone Marrow Transplant Patients A Randomized, Placebo-Controlled TrialElizabeth C. 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CLARK, M.D.Toxicity trial of prophylactic 9-[2-hydroxy-1-(hydroxymethyl)ethoxymethyl]guanine (ganciclovir) after marrow transplantation in dogsAcyclovir for Prevention of Cytomegalovirus Infection and Disease after Allogeneic Marrow TransplantationPrevention and Treatment of Infections After Bone Marrow TransplantationTherapy and Prevention of Cytomegalovirus InfectionsDesign of Nucleoside Analogs as Potential Antiviral AgentsZytomegalievirusinfektion als Ursache von DarmperforationenDrugs Five Years Later: AcyclovirDAVID I. DORSKY, M.D., Ph.D., CLYDE S. CRUMPACKER, M.D.Treatment of Cytomegalovirus Infection 1 August 1986Volume 105, Issue 2Page: 214-215KeywordsBone marrowLung transplantationLungsMortalityNucleosidesPneumonia Issue Published: 1 August 1986 PDF DownloadLoading ...