CONCOMITANT HYPERPARATHYROIDISM AS A CAUSE OF THE HYPERCALCEMIA ASSOCIATED WITH HYPERTHYROIDISM
Authors: C E JACKSON, J S WEBSTER, P C TALBERT, H D CAYLOR
Journal: Annals of Internal Medicine (1961)

Case Reports1 May 1961CONCOMITANT HYPERPARATHYROIDISM AS A CAUSE OF THE HYPERCALCEMIA ASSOCIATED WITH HYPERTHYROIDISMCHARLES E. JACKSON, M.D., F.A.C.P., JOEL S. WEBSTER, M.D., PIERRE C. TALBERT, M.D., F.A.C.S., HAROLD D. CAYLOR, M.D., F.A.C.S.CHARLES E. JACKSON, M.D., F.A.C.P.Search for more papers by this author, JOEL S. WEBSTER, M.D.Search for more papers by this author, PIERRE C. TALBERT, M.D., F.A.C.S.Search for more papers by this author, HAROLD D. CAYLOR, M.D., F.A.C.S.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-54-5-992 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe hypercalcemia reported as occurring in association with hyperthyroidism has been thought by some authors to be caused in some way by the thyrotoxicosis. It is the purpose of this paper to report a patient in whom the hypercalcemia associated with hyperthyroidism was caused by a concomitantly hyperfunctioning parathyroid adenoma. A review of other hypercalcemia cases reported with hyperthyroidism as possibly being caused by concomitant hyperparathyroidism has emphasized interesting possibilities regarding the effect of propylthiouracil on the serum calcium level in hyperparathyroidism.CASE REPORTA 37-year-old woman, wife of a missionary, developed thyrotoxicosis in August, 1957, while living in the...Bibliography1. BallinMorse MPF: Parathyroidism. Amer. J. Surg. 12: 403-416, 1931. CrossrefGoogle Scholar2. Hellström J: Hyperparathyroidism and osteitis fibrosa generalisata. Acta Chir. Scand. 69: 237-304, 1932. Google Scholar3. NobleBorg JFJF: Hyperparathyroidism complicated by hyperthyroidism. Arch. Intern. Med. 58: 846-859, 1936. CrossrefGoogle Scholar4. MillerEvans ESLR: Simultaneous hyperfunction of the thyroid and parathyroid glands. New Engl. J. Med. 227: 949-952, 1942. CrossrefGoogle Scholar5. AarsethBjorgo SE: Hyperparathyroidism; coincidence of parathyroid adenoma, goiter, and exophthalmos; report of case. Acta Endocr. 3: 201-214, 1949. Google Scholar6. Hellström J: Primary hyperparathyroidism; observations in series of 50 cases. Acta Endocr. 16: 30-58, 1954. CrossrefMedlineGoogle Scholar7. UnderdahlWoolnerBlack LOLBBM: Multiple endocrine adenomas: report of 8 cases in which the parathyroids, pituitary and pancreatic islets were involved. J. Clin. Endocr. 13: 20-47, 1953. CrossrefMedlineGoogle Scholar8. Wermer P: Genetic aspects of adenomatosis of endocrine glands. Amer. J. Med. 16: 363-371, 1954. CrossrefMedlineGoogle Scholar9. MoldawerNardiRaker MPGLJW: Concomitance of multiple adenomas of the parathyroids and pancreatic islets with tumor of the pituitary: a syndrome with familial incidence. Amer J. Med. Sci. 228: 190-206, 1954. CrossrefMedlineGoogle Scholar10. Wijnbladh H: Über die thyreotoxischen krisen and ihre behandlung, mit besonderer berucksichtigung der jodbehandlung. Acta Chir. Scand. 79: 507-544, 1937. Google Scholar11. PuppelGrossMcCormickHerdle DHTEKE: The rationale of calcium, phosphorus, and vitamin D therapy in clinical hyperthyroidism. Surg., Gynec., Obstet. 81: 243-265, 1945. Google Scholar12. HuthMayockKerr EJRLRM: Hyperthyroidism associated with renal tubular acidosis. Amer. J. Med. 26: 818-826, 1959. CrossrefMedlineGoogle Scholar13. GreenLyall JA: Calcium metabolism in hyperthyroidism; effect of thiouracil. Lancet 1: 828-830, 1951. CrossrefMedlineGoogle Scholar14. StanleyFazekas MMJ: Thyrotoxicosis simulating hyperparathyroidism. Amer. J. Med. 7: 262-268, 1949. CrossrefMedlineGoogle Scholar15. RoseBoles ERS: Hypercalcemia in thyrotoxicosis. Med. Clin. N. Amer. 37: 1715-1724, 1953. CrossrefGoogle Scholar16. PribekMeade RARC: Thyrotoxicosis simulating hyperparathyroidism. Arch. Intern. Med. 100: 994-997, 1957. CrossrefGoogle Scholar17. EpsteinFreedmanLevitin FHLRH: Hypercalcemia, nephrocalcinosis and reversible renal insufficiency associated with hyperthyroidism. New Engl. J. Med. 258: 782-785, 1958. CrossrefMedlineGoogle Scholar18. Tighe WJ: Temporary hypoparathyroidism following radioactive iodine treatment for thyrotoxicosis. J. Clin. Endocr. 12: 1220-1228, 1952. CrossrefMedlineGoogle Scholar19. FreedbergKurlandBlumgart ASGSHL: The pathologic effects of I131 on the normal thyroid gland of man. J. Clin. Endocr. 12: 1315-1348, 1952. CrossrefGoogle Scholar20. Sallin O: Hypercalcemia nephropathy in thyrotoxicosis. Acta Endocr. 29: 425-434, 1958. CrossrefMedlineGoogle Scholar21. KleemanTuttleBassett CRSSH: Metabolic observations in a case of thyrotoxicosis with hypercalcemia. J. Clin. Endocr. 18: 477-491, 1958. CrossrefGoogle Scholar22. Laake H: Osteoporosis in association with thyreotoxicosis. Acta Med. Scand. 151: 229-235, 1955. CrossrefMedlineGoogle Scholar23. JacksonWebsterTalbertCaylor CEJSPCHD: Propylthiouracil effect on hyperparathyroidism. Clin. Res. 7: 389, 1959. Google Scholar24. FrameDurham BRF: Simultaneous hyperthyroidism and hyperparathyroidism. Amer. J. Med. 27: 824, 1959 CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Bluffton, Indiana*Received for publication November 13, 1959.From the Caylor-Nickel Clinic, Bluffton, Indiana.†Sponsored by the Caylor-Nickel Research Foundation.Requests for reprints should be addressed to Charles E. Jackson, M.D., F.A.C.P., 303 South Main Street, Bluffton, Indiana. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byPrimary hyperparathyroidismConcomitant graves' disease and primary hyperparathyroidism. Influence of hyperthyroidism on serum calcium and parathyroid hormoneHyperparathyroidism in thyrotoxicosisHyperthyroidism and calcium metabolismBony Manifestations of ThyrotoxicosisCALCIUM METABOLISM AND BONE IN HYPERTHYROIDISMHypercalcaemia in thyrotoxicosis with and without hyperparathyroidismCoexistent hyperthyroidism and hyperparathyroidismPseudohyperparathyroidism due to malignant tumorsOsteomalacia in thyrotoxicosisThe ParathyroidsCoexisting Hyperthyroidism and HyperparathyroidismIdiopathic Hypoparathyroidism Associated with HyperthyroidismJAMES R. DAHL, M.D., SAMUEL D. MCFADDEN, M.D., EUGENE EISENBERG, M.D.Suppression of the Hypercalcemia of Thyrotoxicosis by CorticosteroidsHYPERCALCEMIA—DOUBLED CAUSES AND A DILEMMAE. J. H. 1 May 1961Volume 54, Issue 5Page: 992-998KeywordsAdenomasCalciumHypercalcemiaHyperparathyroidismHyperthyroidismParathyroid tumorsThyroidectomy ePublished: 1 December 2008 Issue Published: 1 May 1961 PDF downloadLoading ...