tbuckley/cabot-search huggingface dataset:
Lung Transplantation in Cystic Fibrosis — Primum Non Nocere?
Authors: Julian Allen, Gary Visner
Journal: New England Journal of Medicine (2007)

Cystic fibrosis is one of the most common autosomal recessive diseases. It causes intestinal, pancreatic, and progressive lung dysfunction, which is ultimately lethal. In 1989, the first specific cystic fibrosis gene defect on chromosome 7 was described, and its function was determined shortly thereafter. The cystic fibrosis gene codes for the cystic fibrosis transmembrane regulator (CFTR) protein, a chloride channel that controls chloride and, indirectly, sodium transport across epithelial cells.When CFTR function is lost, excess sodium and chloride are resorbed from the airway lumen, leading to dehydration of the luminal contents and increased fluid viscosity of the airway lining. . . .
Hypersarcosinemia
Authors: Theo Gerritsen, Harry A. Waisman
Journal: New England Journal of Medicine (1966)

A NEW inborn error of amino acid metabolism, hypersarcosinemia with sarcosinuria, was recently reported by us.1 , 2 A ten-month-old male infant who excreted sarcosine, and who had difficulty in swallowing and failure to thrive throughout infancy, was discovered after he was committed to the Central Wisconsin Colony and Training School, a state institution for the mentally retarded. Sarcosine has no known specific role in mammalian metabolism other than being the intermediate between dimethylglycine (DMG) and glycine in the 1-carbon cycle.'1 This amino acid has been reported to be in the protein of the peanut4 and a constituent of the actinomycins.5 The . . .
Sulphadimidine Acetylation Test for Classification of Patients as Slow or Rapid Inactivators of Isoniazid
Authors: K. V. N. Rao, D. A. Mitchison, N. G. K. Nair, K. Prema, S. P. Tripathy
Journal: BMJ (1970)

Sulphadimidine acetylation studies were undertaken in 103 patients, 52 of whom had been classified as slow and 51 as rapid inactivators of isoniazid by a standard microbiological assay method. Each patient received sulphadimidine by mouth in a dose of 44 mg./kg. body weight, and free and total sulphadimidine were estimated in blood and urine collected at six hours. The findings suggest that patients may be classified as slow inactivators of isoniazid if the proportion of acetylated sulphadimidine (total minus free) is (a) less than 25% in blood or (b) less than 70% in urine. The sulphadimidine test is easy to perform and the result is available the same day; urine specimens for the test can be stored at room temperature for over a week without any loss of drug.
Maternal Hyperparathyroidism and Pregnancy
Authors: Alan Rubin
Journal: JAMA (1968)

A history suggestive of renal colic led to the discovery of hyperparathyroidism in a pregnant woman. The patient's past history included nothing to suggest hyperparathyroidism, save an infant born seven years previously who had had hypocalcemic tetany shortly after birth. Surgical exploration was postponed until the second trimester of pregnancy, when a parathyroid adenoma was removed. The patient carried uneventfully to term, and was delivered of a healthy infant who has thrived.
Dynamic Practical Electrocardiography
Authors: Craig H. Scott, Behzad B. Pavri
Journal: Annals of Internal Medicine (2001)

Medical Writings: Book and Software Notes17 April 2001Dynamic Practical ElectrocardiographyCraig H. Scott, MD and Behzad B. Pavri, MDCraig H. Scott, MDUniversity of Pennsylvania, Philadelphia, Pennsylvania. (Scott)Search for more papers by this author and Behzad B. Pavri, MDUniversity of Pennsylvania, Philadelphia, Pennsylvania. (Scott)Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-134-8-200104170-00022 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail Dynamic Practical ElectrocardiographyWagner GS, Waugh RA, Lawson WT. Philadelphia: Lippincott Williams & Wilkins; 2000. Single-user price, $295.00. ISBN 0683305883. Order phone 800-638-0672.Field of medicine: Adult and pediatric cardiovascular medicine.Format: CD-ROM software. Minimum system requirements: PC: Windows 95 or higher, 12 Mb (Windows 95) or 16 Mb (Windows 98 or NT) of RAM, 15 Mb of free hard disk space, a 4× CD-ROM drive, VGA display with 256 colors. Not available for Macintosh.Audience: Students and general practitioners.Purpose: To review the basics of electrocardiography.Content: Textbook material and case studies with questions.Usability: Program setup is straightforward, ... Author, Article, and Disclosure InformationAffiliations: University of Pennsylvania, Philadelphia, Pennsylvania. (Scott) PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 17 April 2001Volume 134, Issue 8Page: 716KeywordsCardiology and cardiovascular diseasesDepolarizationElectrocardiographySoftware tools ePublished: 17 April 2001 Issue Published: 17 April 2001 Copyright & PermissionsCopyright © 2001 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
It's who looks after the catheters that counts
Authors: S. J Kennish
Journal: BMJ (2008)

Maki asserts that the incidence of intravenous catheter complications is greatly reduced when highly experienced nurses insert catheters.1 The single reference provided to support this statement makes interesting reading.2 This randomised controlled trial compares complications in two main groups of patients: those who are cannulated by house doctors and followed up by …
Subacute Bacterial Endocarditis Due to<i>Streptococcus viridans</i>in an Edentulous Man
Authors: Donald Massaro, Sol Katz
Journal: New England Journal of Medicine (1960)

AMONG the most important indigenous microorganisms is the viridans group of streptococci. These bacteria are normal inhabitants of the mouth and pharynx and appear early in life. Although they rarely provoke disease, their most significant contribution to medicine lies in the fact that approximately 75 to 85 per cent of cases of subacute bacterial endocarditis are caused by Streptococcus viridans. In the pathogenesis of subacute bacterial endocarditis these organisms are transported by way of the blood stream to reach valves damaged by rheumatic heart disease or certain forms of congenital heart disease. Transient episodes of Str. viridans bacteremia frequently . . .
FINANCIAL CRISIS, BELIEFS AND ATTITUDES REGARDING CARDIOVASCULAR DISEASE RISK FACTORS: A HEALTH SURVEY IN 10,141 GREEK MEN AND WOMEN (2006-2012)
Authors: Demosthenes Panagiotakos, Ekavi Georgousopoulou, Christine Chrysohoou, Christos Pitsavos, Evangelos Polychronopoulos, Vasilakou Tonia, Vasilios Athyros, John Goudevenos, Christodoulos I Stefanadis
Journal: Journal of the American College of Cardiology (2014)
THE EFFECT OF INHIBITORS OF CHOLESTEROL SYNTHESIS ON SEBUM SECRETION IN PATIENTS WITH ACNE
Authors: W. J. CUNLIFFE, SAM SHUSTER
Journal: British Journal of Dermatology (1969)

Journal Article THE EFFECT OF INHIBITORS OF CHOLESTEROL SYNTHESIS ON SEBUM SECRETION IN PATIENTS WITH ACNE Get access W. J. CUNLIFFE, W. J. CUNLIFFE University Department of Dermatology, Royal Victoria Infirmary, Newcastle upon Tyne Search for other works by this author on: Oxford Academic Google Scholar SAM SHUSTER SAM SHUSTER University Department of Dermatology, Royal Victoria Infirmary, Newcastle upon Tyne Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 81, Issue 4, 1 April 1969, Pages 280–282, https://doi.org/10.1111/j.1365-2133.1969.tb13981.x Published: 01 April 1969 Article history Accepted: 03 September 1968 Published: 01 April 1969
Induction of idiotype-bearing, nuclease-specific helper T cells by in vivo treatment with anti-idiotype.
Authors: G G Miller, P I Nadler, Y Asano, R J Hodes, D H Sachs
Journal: The Journal of Experimental Medicine (1981)

Treatment of BALB/c mice with purified pig anti-(BALB/c anti-nuclease) anti-idiotypic antibodies has been found to induce the appearance of idiotype-bearing immunoglobulins (Id') in the serum of these mice in the absence of detectable antigen binding activity. This phenomenon appeared to require T cells in the hosts because no Id' was detected in the serum of nude mice similarly treated. Furthermore, the spleens of BALB/c mice treated with anti-idiotype were found to contain helper T cells capable of providing help in an in vitro plaque-forming cell response to trinitrophenyl-nuclease equivalent to that provided by helper T cells from the spleens of nuclease-primed animals. Helper T cells from both anti-idiotype-treated and nuclease-treated animals were found to be antigen-specific and to be similarly susceptible to elimination by treatment with anti-idiotype plus complement. Therefore, treatment with both antigen and anti-idiotype appeared to prime similar populations of antigen-specific helper T cells, while having different effects on the induction of antibody. These findings are consistent with the network theory of receptor interactions in the immune response, and may provide a means for studying individual cell populations involved in such interactions.
CASE OF TRACHEOTOMY; WITH REMARKS
Authors: C. Webb
Journal: BMJ (1853)

si circumstances, and presented almost the same ap- parances ; it is therefore unnecessary to go into any lengthened detail.In addition, however, there were several vesications at the end of the prepuce, retention of urine, the distended condition of the bladder being evident in the hypogastric region.The same plan of treatment was pur- sued, and the removal of the foreign body was equally pain-
Clinical Pharmacology and Experimental Therapeutics
Authors: James A. Hagans
Journal: JAMA (1967)

To the Editor:—  Re the letter of Dr. Frederic L. Stone (201:705, 1967) concerning Clinical Pharmacology and Experimental Therapeutics, no amount of word salad in our age of tyranny on words can mask for long to the discerning that the National Institutes of Health activities have been appropriately and accurately and justly described by Dr. John H. Moyer (200:454, 1967). It would seem they have indeed failed to support appropriately the development of experimental therapeutics in the United States. Basic science and basic research are essential in our society, and no thinking man, including Dr. Moyer, would think of denying their appropriate place. When, however, many of these endeavors are supported to theexclusionof applied research in an area as important as human therapeutics, and when men well qualified in basic science and basic researchinappropriately assumethe role of major decision makers for such areas of
Oral Intraoperative Enteroscopy for Diagnosis of Multiple Jejunal Ulcers
Authors: H. Bosseckert, H. Schramm, G. Lungershausen, G. Machnik
Journal: Endoscopy (1981)

In 2 patients suffering from multiple ulcerations of the jejunum preoperative diagnostic measures were unsuccessful. Only by oral intraoperative endoscopy was it possible to diagnose the cause of bleeding and treat it successfully.
Rhinoconjunctivitis, bronchial responsiveness, and atopy as determinants for incident non‐work‐related asthma symptoms in apprentices exposed to high‐molecular‐weight allergens
Authors: D. Gautrin, H. Ghezzo, J.‐L. Malo
Journal: Allergy (2003)

Objective: The aim of this study was to explore the role of rhinoconjunctivitis (RC), taking into account atopy and the level of bronchial responsiveness to methacholine, on the incidence of respiratory symptoms and in the development and/or worsening of asthma. Methods: We examined data from a prospective study in 769 students starting exposure to high‐molecular‐weight occupational allergens and who were serially followed for up to 44 months. Results: The presence of RC symptoms at baseline was significantly associated with an increased risk of developing shortness of breath and wheezing in atopic subjects regardless of PC20 level and in subjects with a PC20 ≤ 32 mg/ml regardless of atopic status. RC symptoms were significantly associated with the development of exercise‐induced respiratory symptoms. Multivariate analyses indicated that having a measurable PC20 was significantly associated with the incidence of all respiratory symptoms studied, whereas baseline seasonal RC was associated only with incident exercise‐induced respiratory symptoms; atopy played a minimal role, and only through an interaction with seasonal RC. Conclusion: Of the three potential factors for the development of respiratory symptoms that we considered, i.e. RC symptoms, having a measurable PC20 and atopy, having a measurable PC20 is the most significant one.
1056-141 Is there value in follow-up stress testing for emergency department patients with chest pain and normal rest SPECT myocardial perfusion?
Authors: Prem Soman, Joni R Beshanksky, Robin Ruthazer, John L Griffith, Gary V Heller, Robert C Hendel, J.Hector Pope, Ethan J Spiegler, James A Feldman, Harry P Selker, James E Udelson
Journal: Journal of the American College of Cardiology (2004)
Peculiarities of carcinogenesis under simultaneous oral administration of benzo(a)pyrene and o-cresol in mice.
Authors: None Yanysheva NYa, N V Balenko, I A Chernichenko, V F Babiy
Journal: Environmental Health Perspectives (1993)

A modifying influence of ortho-cresol (o-cresol) on the carcinogenic effect of benzo(a)pyrene (BaP) with combined oral administration to CC57Br mice had been found. During simultaneous administration of o-cresol (1 mg) and BaP (1 mg), the incidence of tumors, the multiplicity of tumors, and the degree of malignancy all increased, but the latency was shortened. When o-cresol was administered before or after BaP (in identical doses), the carcinogenic effect was weakened. When o-cresol (10 mg) and BaP (5 mg) were administered simultaneously, the incidence of malignant tumors was similar to controls receiving BaP only (13.8%), indicating inhibition of carcinogenesis.
Dickens, Dombey, and Diagnostics
Authors: ALBERT L. FREEDMAN
Journal: Annals of Internal Medicine (1985)

Letters and Corrections1 February 1985Dickens, Dombey, and DiagnosticsALBERT L. FREEDMAN, M.D.ALBERT L. FREEDMAN, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-102-2-271_1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: Although I found Markel's argument (1) of interest, that young Dombey died of acute lymphatic leukemia and that Dickens described its course with great accuracy, I must take issue with his diagnosis.Paul Dombey had always been a sickly child obsessed with intimations of death. He was "not yet five" (2) when sent by doctor's recommendation for "sea-air" to Mrs. Pipchin's establishment, where he grew stronger. He remained there for "nearly twelve months" and he was "six years old" when transferred to Dr. Blimber's establishment for more rigorous education. At Blimber's, Paul "might have answered [the ticking...References1. MARKEL H. Charles Dickens and the art of medicine. Ann Intern Med. 1984;101:408-11. LinkGoogle Scholar2. DICKENS C. Dombey and Son. New York: Penguin Books, Inc.; 1976. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: ALBERT L. FREEDMAN, M.D.Affiliations: 400 Jericho-Hicksville Road; Jericho, NY 11753 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 February 1985Volume 102, Issue 2Page: 271-271KeywordsDiagnostic techniques ePublished: 1 December 2008 Issue Published: 1 February 1985 PDF downloadLoading ...
Changing practice in growth monitoring
Authors: L. D Voss
Journal: BMJ (1999)

The French pay child benefits only on production of a school medical certificate confirming that height measurements are up to date. If the French, why not the British? Height is easily measured, and height velocity is claimed to be a sensitive index of many disorders, genetic, metabolic, and psychosocial. More than just a marker for health, growth could be a useful tool for picking up silent disease. All that we lack is the evidence.

The dilemma of pursuing a screening programme based on a scientifically plausible but unproved hypothesis has recently been raised.1 In particular, the use of growth data to screen for silent disease in children has been the subject of lengthy debate, but there have been few cohort studies on which to judge its effectiveness, and consensus guidelines for referral have yet to emerge. Much of the debate currently relies on evidence from the Wessex growth study, which since 1986 has monitored a cohort of very short children in the …
Personalized Medicine by Analyzing Circulating DNA: Application to the Management Care of Colorectal Cancer Patients
Authors: F. Mouliere, S. El Messaoudi, C. Gongora, P.J. Lamy, M. del Rio, E. Lopez-Crapez, B. Gillet, M. Mathonnet, D. Pezet, M. Ychou, A.R. Thierry
Journal: Annals of Oncology (2013)
Another smoking hazard: raised serum IgE concentration and increased risk of occupational allergy.
Authors: O Zetterstrom, K Osterman, L Machado, S G Johansson
Journal: BMJ (1981)

Individual smoking histories of a general population sample and of two groups of workers exposed to occupational allergens were related to serum IgE concentrations and results of radioallergosorbent and prick tests in the workers. The geometric mean IgE concentration was higher in smokers than in non-smokers. The distribution of serum IgE values in the two groups showed an apparent difference, with a bimodal appearance in the smokers. Evidence of sensitisation against occupational allergens was more common in workers who smoked. The adjuvant effect of smoking on IgE antibody production might be due to damage to airways mucosa and supports the mucosal theory of atopy.
Cytotoxic and mutagenic effects of dental composite materials
Authors: Helmut Schweikl, Karl-Anton Hiller, Carola Bolay, Marion Kreissl, Wetscheslaw Kreismann, Agathe Nusser, Stefanie Steinhauser, Janusz Wieczorek, Rudolf Vasold, Gottfried Schmalz
Journal: Biomaterials (2004)
Swimming Pool Attendance, Asthma, Allergies, and Lung Function in the Avon Longitudinal Study of Parents and Children Cohort
Authors: Laia Font-Ribera, Cristina M. Villanueva, Mark J. Nieuwenhuijsen, Jan-Paul Zock, Manolis Kogevinas, John Henderson
Journal: American Journal of Respiratory and Critical Care Medicine (2010)

Cross-sectional studies have reported inconsistent findings for the association between recreational swimming pool attendance and asthma and allergic diseases in childhood.To examine whether swimming in infancy and childhood was associated with asthma and allergic symptoms at age 7 and 10 years in a UK longitudinal population-based birth cohort, the Avon Longitudinal Study of Parents and Children.Data on swimming were collected by questionnaire at 6, 18, 38, 42, 57, 65, and 81 months. Data on rhinitis, wheezing, asthma, eczema, hay fever, asthma medication, and potential confounders were collected through questionnaires at 7 and 10 years. Spirometry and skin prick testing were performed at 7 to 8 years. Data for analysis were available for 5,738 children.At age 7 years, more than 50% of the children swam once per week or more. Swimming frequency did not increase the risk of any evaluated symptom, either overall or in atopic children. Children with a high versus low cumulative swimming pool attendance from birth to 7 years had an odds ratio of 0.88 (95% confidence interval, 0.56-1.38) and 0.50 (0.28-0.87), respectively, for ever and current asthma at 7 years, and a 0.20 (0.02-0.39) standard deviation increase in the forced midexpiratory flow. Children with asthma with a high versus low cumulative swimming had an odds ratio for current asthma at 10 years of 0.34 (0.14-0.80).This first prospective longitudinal study suggests that swimming did not increase the risk of asthma or allergic symptoms in British children. Swimming was associated with increased lung function and lower risk of asthma symptoms, especially among children with preexisting respiratory conditions.
The boundary between health care and social care
Authors: M. Pearson, G. Wistow
Journal: BMJ (1995)

The Department of Health's recent guidance NHS Responsibilities for Meeting Continuing Health Care Needs1 merits a cautious welcome. It follows a much criticised draft,2 which originated in the health service commissioner's upholding of a complaint that Leeds Healthcare had failed to provide long term NHS care for a brain damaged patient.3 Even so, it does not resolve all the uncertainties about responsibilities at the boundary between health and social care. Still less does it acknowledge the silent, if not surreptitious, shift in the balance between state and individual responsibilities for funding long term care that has taken place over the past 15 years. The profound implications of that shift for the expectations and finances of the current generation of elderly people and their families justify a long overdue public review of the current arrangements and their consequences.4

On the more positive side, however, the final guidance can be seen as more substantial, comprehensive, and prescriptive than its draft precursor. In a climate of increasing concern about pressure on resources in the acute sector and emergency medical admissions5 its overt commitment to continuing care as an …
Ineffectiveness of Subcutaneous Cytosine Arabinoside in Localized Herpes Zoster
Authors: ROBERT F. BETTS
Journal: Annals of Internal Medicine (1975)

Cytosine arabinoside (cytarabine) was evaluated in a randomized double-blind controlled study for the treatment of localized herpes zoster. Cytarabine was administered subcutaneously in a dose of 50 mg/m2body surface area once daily for 4 days, always within 14 days of onset of the first symptom and usually within 7 days. Thirty patients given cytarabine and 30 patients given placebo were well matched with respect to age, sex, and length and severity of presenting rash and pain as well as underlying disease. There was no difference in the rate of disappearance of pain or rash in either treatment group. More patients given cytarabine than patients given placebo had minimal pain and significantly more cytarabine-treated patients had persistence of neurological symptoms at 6 months' follow-up. Acute side effects, though mild, were significantly increased in the cytarabine-treated patients especially with respect to nausea and vomiting and decrease in platelet count. Cytarabine administered in this dose subcutaneously had no beneficial effect and was associated with mild side effects and persistence of neurological symptoms.