tbuckley/cabot-search huggingface dataset:
Abstract 18210: Impact of AHA/ACC Coronary Artery Bypass Grafting and Percutaneous Coronary Intervention Guidelines on Real-world Treatment Strategies for Complex Coronary Artery Disease
Authors: Chenfei Rao, Shengshou Hu, Zhe Zheng, Xin Yuan, Kun Hua, Heng Zhang
Journal: Circulation (2014)

Introduction: 2011 ACCF/AHA coronary artery bypass grafting (CABG) guideline and percutaneous coronary intervention (PCI) guideline were published on December 2011.The aim of this study is to explore the impact of guidelines’ publication on real-world treatment for three-vessel or left-main coronary artery disease (CAD). Hypothesis: The release of revascularization guidelines has a positive impact on real-world practice and 1-year outcomes of patients with complex CAD. Methods: Between July 2011 and September 2012, patients diagnosed as three-vessel or left-main CAD at Fuwai hospital were consecutively enrolled. We reviewed medical records to abstract detailed in-hospital information. The Corelab calculated SYNTAX Scores according to coronary angiograms. We conducted follow-up at 12 months after the index hospitalization. The end point was major adverse cerebral and cardic event (MACCE) including death, myocardial infarction, stroke and additional revascularization. Patients were then divided into pre-guideline group and post-guideline group according to the conary angiography date. Binary viariables logistic model and Cox model were uesd for baseline and 1-year outcomes comparison respectively Results: 1746 patients were consecutively enrolled. 37.9% (662) were in pre-guideline group, 62.1% (1084) in post-guideline group. There were no significant differences in demographic factors, cardiac surgery risks and SYNTAX Scores between pre- and post-guideline groups. After the publication of 2011 ACCF/AHA guidelines, doctors recommended more patients to choose CABG (pre: 49.0%, post: 55.6%, p&lt;0.05), the surgeons’ consultation rate increased (pre: 41.9%, post: 49.9%, p&lt;0.05), the rate of ad hoc PCI (PCI immediately after coronary angiography) decreased (pre: 47.5%, post: 40.9%, p&lt;0.05). After adjustment for coronary anatomy complexity and cardiac surgery risks using Cox model, pre-guideline group was associated with significantly higher rates of MACCE (HR=1.62, 95% confidential interval: 1.15-2.27). Conclusions: The publication of 2011 ACCF/AHA CABG and PCI guidelines significantly changed real-world treatment for complex CAD in Fuwai hospital, and further improved outcomes.
THE LEUKOCYTE PICTURE IN HODGKIN'S DISEASE
Authors: Grace M. Roth, Charles H. Watkins
Journal: Annals of Internal Medicine (1936)

Article1 April 1936THE LEUKOCYTE PICTURE IN HODGKIN'S DISEASEGRACE M. ROTH, B.S., CHARLES H. WATKINS, M.D., F.A.C.P.GRACE M. ROTH, B.S., CHARLES H. WATKINS, M.D., F.A.C.P.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-9-10-1365 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptAlthough Hodgkin's1 disease was described by him as early as 1832, the blood picture in this disease was not seriously considered until 1910. At that time Fabian,2 after a critical survey of the literature, reported that the blood picture was not sufficiently constant to be of any diagnostic value. He did state, however, that the most frequent hematologic finding in Hodgkin's disease was a moderate increase in the number of polymorphonuclear neutrophiles and a relative decrease in the number of lymphocytes.In 1911, following this survey, Bunting3reported the analysis of a small series of blood counts in cases of...Bibliography1. HODGKIN T: On some morbid appearance of the absorbent glands and spleen, Trans. Medico-Chir. Soc. Edinburgh, 1832, xvii, 68-114. Google Scholar2. FABIAN E: Über den Blutbefund der Lymphogranulomatosis (Paltauf-Sternberg): nebst Bemerkungen über die Blutveränderungen bei der Lymphsarkomatosis und der Lymphdrüsentuberkulose, Wien. klin. Wchnschr., 1910, xxiii, 1515-1519. Google Scholar3. BUNTING CH: The blood-picture in Hodgkin's disease, Bull. Johns Hopkins Hosp., 1911, xxii, 369-372. Google Scholar4. BUNTING CH: The blood-picture in Hodgkin's disease (second paper), Bull. Johns Hopkins Hosp., 1914, xxv, 173-177. Google Scholar5. YATES JL: A clinical consideration of Hodgkin's disease, Bull. Johns Hopkins Hosp., 1914, xxv, 180-194. Google Scholar6. LONGCOPEMCALPIN WTKR: Hodgkin's disease, 1920, Oxford Medicine, vol. 4, pt. 1, 1-43. Google Scholar7. MCALPIN KR: Blood counts in Hodgkin's disease, Arch. Int. Med., 1923, xxxii, 954-957. CrossrefGoogle Scholar8. WEISS J: Das Leukozytenbild der Lymphogranulomatose, Wien. klin. Wchnschr., 1924, xxxvii, 389-391. Leukocytes in lymphogranulomatosis, Abstr. In: Jr. Am. Med. Assoc., 1924, lxxxii, 1743. Google Scholar9. FALCONER EH: The blood picture in Hodgkin's, Calif. and West. Med., 1930, xxxii, 83-87. Google Scholar10. STRAUBE G: Über das Blutbild der Lymphogranulomatose, Folia haematol., 1931, xliv, 125-136. Google Scholar11. KERNOHAN JW: Personal communication to the authors. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Rochester, Minnesota*Abstract of paper read before the Central Society for Clinical Research, Chicago, Illinois, November 1, 1935.From the Mavo Foundation and the Division of Medicine, the Mayo Clinic, Rochester, Minn. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 April 1936Volume 9, Issue 10Page: 1365-1372KeywordsBloodBlood countsHodgkin lymphomaLymphocytes Issue Published: 1 April 1936 PDF downloadLoading ...
Metabolism Links Bacterial Biofilms and Colon Carcinogenesis
Authors: Caroline H. Johnson, Christine M. Dejea, David Edler, Linh T. Hoang, Antonio F. Santidrian, Brunhilde H. Felding, Julijana Ivanisevic, Kevin Cho, Elizabeth C. Wick, Elizabeth M. Hechenbleikner, Winnie Uritboonthai, Laura Goetz, Robert A. Casero, Drew M. Pardoll, James R. White, Gary J. Patti, Cynthia L. Sears, Gary Siuzdak
Journal: Cell Metabolism (2015)
Abstract 18201: The Association between HMG-CoA Reductase Inhibitor Use and Neurological Outcome Following Cardiac Arrest in Patients Treated with Therapeutic Hypothermia
Authors: Benjamin Holmes, Nyal Borges, Kyle Mandsager, Yanna Song, MIchael Young, John McPherson
Journal: Circulation (2014)

Introduction: HMG-CoA reductase inhibitors (statins) are known to reduce both inflammation and oxidative stress - key components within the pathophysiologic cascade of anoxic brain injury and reper...
Abstract P227: Diabetes Mellitus and Venous Thromboembolism: A Systematic Review and Meta-analysis
Authors: Elizabeth J Bell, Aaron R Folsom, Pamela L Lutsey, Elizabeth Selvin, Mary Cushman, Neil A Zakai, Alvaro Alonso
Journal: Circulation (2014)

Introduction: Reported associations of diabetes with venous thromboembolism (VTE) are inconsistent. We conducted a systematic review and meta-analysis to quantify the association between diabetes mellitus (type 1 or 2) and VTE (deep vein thrombosis or pulmonary embolism). Methods: A systematic review of observational studies was conducted using PubMed, Web of Science, and CINAHL through Dec 31, 2012. Additional studies were identified by contacting experts and through manual review of reference lists of review articles and articles eligible for the present study. We abstracted information on relative risk (RR) estimates and pooled these data using a random-effects model. We queried authors of papers that did not adjust for important confounders to request controlled RR estimates. Results: We identified 10 studies (N participants: 240,940; 7 cohort, 3 case-control: Heit, Lidegaard, and Poulter) which provided RRs adjusted for age and BMI (Figure), and 8 additional studies which did not adjust for these confounders (N participants = 150,205). The pooled RR for the association of diabetes with VTE in the 10 studies was 1.18 (95% CI, 1.03-1.34). The test for heterogeneity was not significant (I 2 = 23.8%, p = 0.22). Amongst the 10 studies, smaller studies tended to have lower RR estimates: Both the Begg and Egger tests were significant (p = 0.02 and 0.01, respectively). The other 8 studies showed evidence of significant between-study heterogeneity (I 2 = 75.5%, p &lt;0.0001), making a pooled estimate inappropriate. Conclusions: Diabetes is associated with an 18% increased risk of VTE in observational studies after accounting for age and obesity. Possible explanations for the association of diabetes with VTE include increased hypercoagulability or vascular damage caused by the metabolic derangements of diabetes or increased exposure to VTE risk factors in individuals with diabetes. Further research is needed to elucidate the mechanisms of this association and whether improved control of diabetes is associated with reduced VTE risk.
Late-breaking abstract: Novel thoraco-abdominal motion analysis technology can measure early respiratory changes following lung resection
Authors: Ghazi Elshafie, Willem de Boer, Richard Steyn, Ehab Bishay, Maninder Kalkat, Pala Rajesh, Rachel Wilson, Babu Naidu
Journal: European Respiratory Journal (2014)

OBJECTIVES: Pulmonary complications (atelectasis, pneumonia) are common following lung resection and are a major cause of morbidity. Identifying complications early and ‘at risk9 patients may allow us to target more effective therapy. Thus we evaluated the viability of a novel portable device to measure dynamic thoraco-abdominal/lung function immediately after lung resection.  METHODS: Structured Light Plethysmography (SLP) measures both rib cage and abdominal motion using a light grid which is simultaneously ‘seen9 by a digital vision system. Grid movement during breathing is analysed and displayed in terms of regional thoraco-abdominal movement parameters as well as a 3D reconstruction. Measurements were made during quiet breathing, before and up to 4 days post operatively.  RESULTS: 9 male patients with a mean age of 72 (range from 63 to 82) years, who underwent lung resection either via VATS (n:4) or Thoracotomy (n:5) were recruited. 96 % of all planned measurements could be performed, all without complications or discomfort to patients. SLP detected a significant reduction in the rib cage contribution to overall ventilation on the operated side in all patients one day after surgery compared to pre-operative measures (7% +/- 5.4 % p  CONCLUSION: SLP is a feasible, acceptable safe technique that can detect immediate regional changes in ventilation following lung resection and differentiate types of surgery. Further studies are required to determine usefulness of measures.
Chernobyl’s Deadly Legacy
Authors: Joan Stephenson
Journal: JAMA (2005)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Abstract P2-13-27: Nipple sparing mastectomy: Risks of wound complication in the setting of neo-adjuvant or adjuvant chemotherapy and/or radiation therapy
Authors: Selyne Samuel, Rebecca Viscusi, Amy Waer, Victor Gonzalez, Pavani Chalasani, Craig Hurst, Ethan Larson, Robert Livingston, Michele Ley
Journal: Cancer Research (2015)

Abstract Background: Surgical care of breast cancer has evolved significantly over the past 40 years. Nipple sparing mastectomy (NSM) and skin sparing mastectomy (SSM) have become an increasingly used surgical management for women with malignant breast disease. To date, there are limited recommendations about the role of NSM in patients receiving aggressive adjuvant therapy. The purpose of this investigation is to determine whether NSM in the setting of neo-adjuvant or adjuvant chemotherapy and/or radiation therapy increased the risks for wound complications. Methods: A retrospective chart review of nipple sparing mastectomies at a single institution was performed from 2007 to 2014. Multiple data points including neo-adjuvant or adjuvant chemotherapy and/or radiation therapy, obesity, smoking history, and type of reconstructive surgery were examined in detail. Results: We counted the procedures by breasts affected and identified 76 NSM in the time period which met criteria. Of the 76 NSMs, 27 breasts received neo-adjuvant(20) or adjuvant chemotherapy and/or radiation(7) therapy. 21 breasts in the NSM group developed wound complications including skin flap necrosis (5), total nipple necrosis and loss (11) hematoma (2) infection(2) and seroma(1). The complications were seen in 11 in the non adjuvant treated setting (14%) and 9 (33%) in the adjuvant therapy setting. Conclusions: Nipple sparing mastectomy are emerging as safe and adequate options for the management of malignant breast disease. Our results show there is a significant risk of wound complication associated with neo-adjuvant and adjuvant chemotherapy and radiation therapy in the setting of nipple sparing mastectomy. We are pursuing the development of new surgical techniques and guidelines to reduce these risks in these high risk patients. Citation Format: Selyne Samuel, Rebecca Viscusi, Amy Waer, Victor Gonzalez, Pavani Chalasani, Craig Hurst, Ethan Larson, Robert Livingston, Michele Ley. Nipple sparing mastectomy: Risks of wound complication in the setting of neo-adjuvant or adjuvant chemotherapy and/or radiation therapy [abstract]. In: Proceedings of the Thirty-Seventh Annual CTRC-AACR San Antonio Breast Cancer Symposium: 2014 Dec 9-13; San Antonio, TX. Philadelphia (PA): AACR; Cancer Res 2015;75(9 Suppl):Abstract nr P2-13-27.
bFGF and VEGF inhibit radiation-induced apoptosis of endothelial cells by inhibiting acid sphingomyelinase activity
Authors: Jean-Philip Truman, Dolares Hambardzumyan, Monica Garcia-Barros, Michael Chan, Richard Kolesnick, Zvi Fuks, Adriana Haimovitz-Friedman
Journal: Cancer Research (2006)

Proc Amer Assoc Cancer Res, Volume 47, 2006

4392 

Previous studies (Haimovitz-Friedman et al., 1994) showed that ionizing radiation (RT) induces rapid sphingomyelin (SM) hydrolysis to generate ceramide and apoptosis in enucleated bovine aortic endothelial cells (BAEC). These studies indicated that the cellular membrane is the primary target of ionizing radiation in these cells. We also showed that basic fibroblast growth factor (bFGF) inhibits RT-induced apoptosis in these endothelial cells. The goal of the current study was to explore the mechanism by which bFGF inhibits RT-induced apoptosis in BAEC and whether other survival factors, such as VEGF, act similarly. The response of these cells to RT in the presence or absence of bFGF and VEGF was investigated using plateau-phase BAEC cultures. Both growth factors inhibited RT-induced apoptosis in these cells. Further, ceramide levels were significantly elevated at 266.4pmol/106 cells 60 seconds post-irradiation (p<0.001), and were reduced to basal levels upon pretreatment with bFGF (129.4pmol/106 cells in bFGF-pretreated irradiated cells vs. 138.44pmol/106 cells in untreated control BAEC). In resting cells, acid sphingomyelinase (ASMase) is localized to the inner plasma membrane and upon activation translocated onto the exoplasmic leaflet, where its substrate SM is preferentially concentrated. bFGF inhibited RT-induced ASMase translocation, and decreased ASMase activity. Further, exogenous long chain C16-ceramide, at concentrations alone insufficient for apoptosis induction, bypassed bFGF and VEGF inhibition and restored radiation-induced apoptosis. These results show for the first time that the principle anti-apoptotic effect of bFGF and VEGF on endothelium is to inhibit ASMase-mediated ceramide generation.
Study of 100 000 children is due to start next year
Authors: Marwick Charles
Journal: BMJ (2005)

A US study of 100 000 children that will look at environmental influences on their health took a step forward last week, when the US government announced it had granted the first six contracts for the study.

The national children's study, described as the largest of its type ever undertaken, has been five years in the planning and will cost an estimated $2.7bn (£1.5bn; £2.3bn). It was mandated by Congress in 2000 and is being run together with other federal agencies such as the Environmental Protection Agency and the Centers for Disease Control and Prevention.

The study …
Brain-derived nerve factor and neurotrophins in androgenetic alopecia
Authors: R. Panchaprateep, W. Korkij, P. Asawanonda
Journal: British Journal of Dermatology (2011)

Several growth factors and cytokines have been shown to be involved in normal hair cycling as well as in androgenetic alopecia (AGA). However, the molecular cascades in AGA downstream from androgen receptor activation are far from being fully elucidated.We sought to determine the difference in the protein expression of growth factors/cytokines in balding vs. nonbalding scalp specimens from the same individuals affected with AGA.Balding and nonbalding scalp specimens were collected from four men with pattern baldness. Dermal papilla (DP) cells were isolated and cultured. Quantifying the protein expression of growth factors and cytokines expressed by these cells was performed using Quantibody® Human Growth Factor Array-1 (RayBiotech, Inc., Norcross, GA, U.S.A.).Brain-derived nerve factor (BDNF) protein expression was upregulated by approximately 12-fold in supernatants obtained from balding as compared with nonbalding DP cells (P < 0·001). Expression of neurotrophin-3 and of β-nerve growth factor was also upregulated. On the other hand, protein expression of insulin-like growth factor-1 and its binding proteins as well as of the vascular endothelial growth factor family were significantly downregulated in the balding scalp.Neurotrophic factors, especially BDNF, may be important in mediating the effects of androgens on hair follicles, serving as a negative regulatory control signal. Further studies may lead to novel pharmacological interventions in AGA.
Biological factors predicting response to chemotherapy (CT) in advanced non small cell lung cancer (NSCLC): a feasibility study on tissue collection
Authors: Anne-Pascale Meert, Thierry Berghmans, Céline Mascaux, Marianne Paesmans, Ingrid CsToth, Lucas Willems, Nathalie Leclercq, Géraldine Anthoine, Jean-Paul Sculier
Journal: European Respiratory Journal (2010)
Discovery of 2,4-diaryl-2,5-dihydropyrrole inhibitors of the mitotic kinesin KSP
Authors: Mark E. Fraley, Ken Arrington, Bill Hoffman, Rob Garbaccio, George Hartman, Rob Lobell, Carolyn Buser, Weikang Tao, Hans Huber, Nancy Kohl
Journal: Cancer Research (2005)

Proc Amer Assoc Cancer Res, Volume 46, 2005

SY13-1 

Mitotic kinesins are involved in bipolar spindle assembly, maintenance and elongation, chromosome alignment and segregation, and microtubule depolymerization, among other functions during cell division. KSP is a mitotic kinesin that causes centrosome separation, a process required for bipolar spindle formation and maintenance. Inhibition of KSP results in collapse of bipolar spindles and gives rise to monopolar spindle arrays, referred to as monoasters. Importantly, this phenotype is accompanied by cell cycle arrest in mitosis, and prolonged mitotic arrest in tumor cells can lead to apoptosis. KSP inhibitors therefore have potential as general antiproliferative agents useful for the treatment of cancer. Additionally, KSP inhibition represents a novel and specific mechanism by which to target the mitotic spindle that may be devoid of the neuropathy-associated, mechanism-based side effects common to the taxanes and other natural products that target microtubules. KSP inhibitors may also offer advantages over these agents with regard to formulation and tumor resistance. In this presentation, we disclose the development of 2,4-diaryl-2,5-dihydropyrroles as novel, potent and selective inhibitors of KSP. The evolution of this class from a 3,5-diaryl-4,5-dihydropyrazole lead structure will be described with emphasis on modifications to the N-1 substituent of the dihydropyrrole nucleus that provided potency and aqueous solubility simultaneously. Initial optimization efforts in this series led to the identification of compound 1 (KSP IC50 = 2.0 nM). Compound 1 caused mitotic arrest in vitro in A2780 human ovarian carcinoma cells (EC50 = 8.6 nM) and upon prolonged exposure activated caspase-3 (EC50 = 11 nM) and induced apoptosis as determine by FACS analysis. Furthermore, compound 1 caused mitotic arrest, induced apoptosis and inhibited tumor growth in vivo in A2780 tumors in mice. An analysis of the novel binding mode of compound 1 will be provided along with a summary of its physiochemical properties and pharmacokinetics in animals. A scalable asymmetric synthetic route to compound 1 will also be highlighted in this presentation.
Abstract 12116: Peripheral α7-Nicotinic Acetylcholine Receptors Contribute to Cardio-Protective Effects of Central Donepezil Infusion in Chronic Heart Failure Rats
Authors: Meihua Li, Can Zheng, Toru Kawada, Masashi Inagaki, Kazunori Uemura, Masaru Sugimachi
Journal: Circulation (2014)

Introduction: Previous studies have proven that oral administration of donepezil improves prognosis in chronic heart failure (CHF) rats, and most of the cardioprotection has been reproduced by central donepezil infusion. α7-Nicotinic acetylcholine receptors (α7-nAChR) reportedly play an important role in cholinergic anti-inflammation and angiogenesis. The present study aimed to examine whether peripheral blockade of α7-nAChR attenuates beneficial effects of central donepezil infusion in CHF rats. Methods: One week after extensive (50±3%) myocardial infarction (MI), survived rats were implanted with an ECG or a blood pressure transmitter for monitoring chronic hemodynamics. Seven days after surgery, these rats (n=30) were treated with central donepezil infusion (0.1 mg/kg/day) and were randomly assigned to peripheral saline (SDT) or peripheral α7-nAChR blocker, methyllcaconitine (α7DT) infusion groups. After 6-week treatment, the effects of peripheral α7-nAChR blockade were evaluated by hemodynamics, neuro...