tbuckley/cabot-search huggingface dataset:
Labetalol and Determinations of Pressor Hormones
Authors: C. HARVENGT
Journal: Annals of Internal Medicine (1984)

Letters and Corrections1 February 1984Labetalol and Determinations of Pressor HormonesC. HARVENGT, M.D., PH.D.C. HARVENGT, M.D., PH.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-100-2-314_1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: The recent editorial on labetalol (1), released in Belgium several years ago, does not mention the interference of the drug with the fluorimetric determination of urinary catecholamines and metanephrines (2). We have seen marked apparent elevation of these pressor metabolites in hypertensive patients on labetalol. Some patients, referred to our hospital for further study, have had aortic arteriography done to exclude a secreting pheochromocytoma. This spurious elevation of the urinary metanephrines was not confirmed by gas-liquid chromatography (3).The mechanism of this interference lies in adsorption of the drug itself or one of its metabolites to alumina,...References1. MICHELSONFRISHMAN EW. Labetalol: an alpha- and beta-adrenoceptor blocking drug. Ann Intern Med. 1983;99:553-5. LinkGoogle Scholar2. Combined alpha-and beta-adrenergic blockade in the treatment of hypertension: myth or reality? J Cardiovas Pharmacol. 1983;3(suppl 1):S1-74. Google Scholar3. VAN DE CALSEYDESCHOLTISSCHMIDTLEYTEN JRNC. Gas chromatography in the estimation of urinary metanephrines and VMA. Clin Chim Acta. 1971;32:361-6. CrossrefMedlineGoogle Scholar4. MIANOKOLLOCHDE QUATTRO LRV. Increased catecholamine excretion after labetalol therapy: a spurious effect of drug metabolites. Clin Chim Acta. 1979;95:211-7. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: C. HARVENGT, M.D., PH.D.Affiliations: PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byInterference of labetalol metabolites in the determination of plasma catecholamines by HPLC with electrochemical detection 1 February 1984Volume 100, Issue 2Page: 314-314KeywordsAngiographyCatecholaminesDrugsGas liquid chromatographyHormonesMetabolitesPheochromocytoma ePublished: 1 December 2008 Issue Published: 1 February 1984 PDF downloadLoading ...
Family satisfaction in the intensive care unit: a quantitative and qualitative analysis
Authors: Daniel Schwarzkopf, Susanne Behrend, Helga Skupin, Isabella Westermann, Niels C. Riedemann, Rüdiger Pfeifer, Albrecht Günther, Otto W. Witte, Konrad Reinhart, Christiane S. Hartog
Journal: Intensive Care Medicine (2013)
Enhanced basal and disorderly growth hormone secretion distinguish acromegalic from normal pulsatile growth hormone release.
Authors: M L Hartman, S M Pincus, M L Johnson, D H Matthews, L M Faunt, M L Vance, M O Thorner, J D Veldhuis
Journal: Journal of Clinical Investigation (1994)

Pulses of growth hormone (GH) release in acromegaly may arise from hypothalamic regulation or from random events intrinsic to adenomatous tissue. To distinguish between these possibilities, serum GH concentrations were measured at 5-min intervals for 24 h in acromegalic men and women with active (n = 19) and inactive (n = 9) disease and in normal young adults in the fed (n = 20) and fasted (n = 16) states. Daily GH secretion rates, calculated by deconvolution analysis, were greater in patients with active acromegaly than in fed (P < 0.05) but not fasted normal subjects. Significant basal (nonpulsatile) GH secretion was present in virtually all active acromegalics but not those in remission or in fed and fasted normal subjects. A recently introduced scale- and model-independent statistic, approximate entropy (ApEn), was used to test for regularity (orderliness) in the GH data. All but one acromegalic had ApEn values greater than the absolute range in normal subjects, indicating reduced orderliness of GH release; ApEn distinguished acromegalic from normal GH secretion (fed, P < 10(-12); fasted, P < 10(-7)) with high sensitivity (95%) and specificity (100%). Acromegalics in remission had ApEn scores larger than those of normal subjects (P < 0.0001) but smaller than those of active acromegalics (P < 0.001). The coefficient of variation of successive incremental changes in GH concentrations was significantly lower in acromegalics than in normal subjects (P < 0.001). Fourier analysis in acromegalics revealed reduced fractional amplitudes compared to normal subjects (P < 0.05). We conclude that GH secretion in acromegaly is highly irregular with disorderly release accompanying significant basal secretion.
Isolated Intraspinal Extradural Tuberculosis
Authors: John D. H. Johnston, T. Shelly Ashbell, Hubert L. Rosomoff
Journal: New England Journal of Medicine (1962)

TUBERCULOMAS of the central nervous system are not common occurrences. In a series of 5344 patients with known pulmonary tuberculosis, there was but 1 case.1 Among a group of 38,510 patients admitted to a neurosurgical clinic in a community where the prevalence rate of tuberculosis is high, there were 9 intraspinal and 201 intracranial tuberculomas.2 The 9 intraspinal tuberculomas were found in a series of 439 intraspinal tumors.A total of 200 intraspinal tuberculomas have been described in the available medical literature of the past seventy years. From this number, 7 reports of isolated, extradural mass lesions, without evidence of . . .
Impact of gender on asthma in childhood and adolescence: a GA<sup>2</sup>LEN review
Authors: C. Almqvist, M. Worm, B. Leynaert
Journal: Allergy (2007)

A number of studies have shown gender differences in the prevalence of wheeze and asthma. The aim of this review was to examine published results on gender differences in childhood and adolescent asthma incidence and prevalence, define current concepts and to identify new research needs. A Medline search was performed with the search words (gender OR sex) AND (child OR childhood OR adolescence) AND (asthma). Articles that reported on absence or presence of gender differences in asthma were included and reviewed, and cross-references were checked. Boys are consistently reported to have more prevalent wheeze and asthma than girls. In adolescence, the pattern changes and onset of wheeze is more prevalent in females than males. Asthma, after childhood, is more severe in females than in males, and is underdiagnosed and undertreated in female adolescents. Possible explanations for this switch around puberty in the gender susceptibility to develop asthma include hormonal changes and gender-specific differences in environmental exposures. This aspect needs consideration of the doctors and allergists who diagnose and treat asthmatic individuals. In conclusion, sex hormones are likely to play an important role in the development and outcome of the allergic immune response and asthma in particular. By obtaining functional data from appropriate models, the exact underlying mechanisms can be unravelled. To examine the effect of gender-specific differences in environmental exposures and changes of asthma prevalence and severity in puberty, larger populations may need to be investigated.
Absence of Urine Production Due to Renal Failure Enables Clear Visualization of Primary Urinary Bladder Carcinoma on 18F-FDG PET/CT
Authors: Francesco Bertagna, Federica Motta, Simona Fisogni, Marco Schiavo Lena, Silvia Lucchini, Raffaele Giubbini
Journal: Clinical Nuclear Medicine (2012)

An 81-year-old man affected by renal failure, underwent 18F-FDG PET/CT for detecting primary lesion because of multiple lung nodules consistent with secondary lesions revealed by computed tomography without contrast. PET study documented high pathologic uptake at anterior and upper wall of urinary bladder, and a primary urinary bladder cancer was suspected. Biopsy confirmed the presence of a high-grade transitional cell carcinoma.
Impact of NOTCH1/FBXW7 mutations on outcome in pediatric T-cell acute lymphoblastic leukemia patients treated on the MRC UKALL 2003 trial
Authors: S Jenkinson, K Koo, M R Mansour, N Goulden, A Vora, C Mitchell, R Wade, S Richards, J Hancock, A V Moorman, D C Linch, R E Gale
Journal: Leukemia (2012)
The Emergence of Methicillin-Resistant<i>Staphylococcus aureus</i>Infections in United States Hospitals
Authors: ROBERT W. HALEY
Journal: Annals of Internal Medicine (1982)

Infections with methicillin-resistant strains of Staphylococcus aureus appear to be occurring with increasing frequency in some U.S. hospitals about a decade after a similar increase in Britain and other countries. In the United States, clustered methicillin-resistant S. aureus infections reported in scientific journals and in three hospital surveys have been almost entirely in large, tertiary referral hospitals affiliated with medical schools. Among 63 hospitals regularly reporting infections from 1974 to 1981 in the National Nosocomial Infections Study, the increase in methicillin-resistant S. aureus infections was entirely due to substantial increases in only four hospitals, all of which were large, tertiary referral centers affiliated with medical schools. The predominance of methicillin-resistant S. aureus infections in these large hospitals may be due to the large numbers of patients at high risk of infection and to the interhospital spread of the organism by the transfer of infected patients and house staff from similar hospitals or from nursing homes.
Serum Cholesterol and Death From Coronary Heart Disease
Authors: Robert E. Olson
Journal: JAMA (1987)

<h3>To the Editor.—</h3> I am writing to protest the conclusions of the recent article by Stamler et al<sup>1</sup>entitled "Is Relationship Between Serum Cholesterol and Risk of Premature Death From Coronary Heart Disease Continuous and Graded?" Stamler et al conclude that "these data of high precision show that the relationship between serum cholesterol and CHD [coronary heart disease] is<i>not</i>a threshold one, with increased risk confined to the two highest quintiles, but rather is a continuously graded one that powerfully affects risk for the great majority of middle-aged American men." The problem with the article by Stamler et al is that they do not provide convincing evidence that the CHD mortality in the lowest three quintiles is significantly different from that in the first. Ninety-five percent confidence limits are not given for any of the data in any of the quintiles, so it is very difficult to interpret
STUDIES ON IMMUNE HUMAN HEMOLYSIS
Authors: Carl F. Hinz, Mary E. Picken, Irwin H. Lepow
Journal: The Journal of Experimental Medicine (1961)

The Donath-Landsteiner reaction was studied using low and high titer antisera and purified antibody, normal and PNH erythrocytes, and human serum complement. The requirement for complement in both the cold and warm phases of the reaction depended upon the level of antibody used and the sensitivity of the cells to hemolytic antibodies. Complement was not necessary in the cold phase using PNH cells and a potent source of antibody, but complement was required to be present at some stage if hemolysis were to occur. Optimal conditions for the cold phase were at 1 degrees C. for 30 minutes at pH 7.4. Ca(++) ions were required. Hemolysis in the warm phase occurred within one minute, was optimal at 32 degrees C., and required Mg(++). The relation of these observations to previous reports is discussed with respect to discrepant observations on the nature of the Donath-Landsteiner reaction.
Clinical Oncology Program: A Community Cancer Control Model
Authors: W. M. Dugan, D. J. Minnick, J. R. Wood, K. S. Dailey, M. A. Jansen, R. G. Lohrman, D. N. Buell
Journal: CA A Cancer Journal for Clinicians (1979)

The majority of cancer patients are diagnosed and treated in their local communities, making it imperative to upgrade cancer management at the community level. The Clinical Oncology Program has demonstrated that sophisticated cancer control programs are possible in a community setting. Moreover, if "quality of survival" data collection is included in such programs, valuable information emerges that can further improve cancer management in the community.
Unusual spinal tuberculosis after adequate chemotherapy for lymph node tuberculosis in an immunocompetent man.
Authors: S P O'Hickey, A Pithie, C Skinner
Journal: Thorax (1992)

A 35 year old man developed paraplegia due to an epidural mass 15 months after completion of a full chemotherapy course for pulmonary and lymph node Mycobacterium bovis infection. His cellular immune function was normal after treatment. It is suggested that the lesion was a granulomatous healing response rather than bacteriological recurrence.
Pelvic Hydatid Cysts and Obstructed Labour
Authors: M. P. Embrey
Journal: BMJ (1938)

Case IA girl aged 11 was admitted to hospital on December 13, 1937, with a history of three days' illness-typical acute osteo- myelitis of the lower end of the right femur with abscess formation.The child was very ill, and had a temperature of 102°and pulse of 126.An incision was made down to the bone, which was not drilled (Mr. S. G. Davidson4).On the 17th there was pain and swelling of the left tibia, followed on the 18th by pain and swelling of the right humerus.Uleron, 7grains, was given thrice daily for about a week, beginning on December 17.Three days after uleron was started the temperature began to fall and the general condition rapidly improved.There was no operative treatment for the tibia or humerus.The patient was discharged in April, 1938, with the wound in the right leg healed.Skiagrams showed the typical appearance of osteomyelitis in tht femur, tibia, and humerus.Staphylococcus aureus was found in the pus.The report from a blood culture was negative, but there must have been considerable blood infection, as proved by the appearance of two very definite secondary foci. Case IIA boy aged 4 was admitted to hospital on July 15, 1938, with a history of three days' illness, and also of swelling and pain at the lower end of the femur.The appearance was typical of osteomyelitis; temperature 102°, pulse 160.The child was gravely ill, and it was considered that any operative procedur-e was not justified.Uleron was given every four houi-s and continued for three weeks, when the child's face began to look rather bluish and use of the drug was dis-
Cystitis Emphysematosa
Authors: W. A. Milner, W. B. Garlick, C. Mamonas
Journal: New England Journal of Medicine (1952)

CYSTITIS emphysematosa is a rare urologic disease. Its rarity may be more apparent than real. Mills has defined it as an "emphysematous condition of the bladder wall associated with cystitis and hemorrhage."1 The presence of gas in the bladder wall is not a unique situation in the human being, for pneumatosis intestinalis and colpitis emphysematosa in women occur not infrequently. They are apparently not part of the same condition. Various domestic animals have been shown to have the disease.2 In man the majority of cases of cystitis emphysematosa have been observed at autopsy. Approximately 50 cases have been reported in . . .
Clinical and histologic spectrum of nonalcoholic fatty liver disease associated with normal ALT values
Authors: Pouneh Mofrad, Melissa J. Contos, Mahmadul Haque, Carol Sargeant, Robert A. Fisher, Velimir A. Luketic, Richard K. Sterling, Mitchell L. Shiffman, Richard T. Stravitz, Arun J. Sanyal
Journal: Hepatology (2003)

A retrospective study was performed to (1) characterize the clinical and histologic features of those with nonalcoholic fatty liver disease (NAFLD) and normal alanine aminotransferase (ALT) values, (2) compare the spectrum of NAFLD associated with normal versus elevated ALT levels, and (3) determine whether there were differences in the clinical or histologic spectrum of NAFLD between those with a low normal versus high normal ALT value. A total of 51 subjects with NAFLD and normal ALT were identified and compared with 50 consecutive subjects with NAFLD and elevated ALT. The major indications for liver biopsy in those with normal ALT were unexplained hepatomegaly (n = 21) and evaluation as a potential donor for living donor liver transplantation (n = 16). The 2 groups were comparable with respect to age, gender distribution, and ethnicity. Approximately 80% of cases in both groups had at least 1 feature of the metabolic syndrome, the major risk factor for NAFLD. The 2 groups were also comparable with respect to the grade of the individual histologic parameters of NAFLD. A total of 12 subjects with normal ALT levels had bridging fibrosis, whereas 6 had cirrhosis. Diabetes was the only factor independently associated with an increased risk of advanced fibrosis (bridging fibrosis or cirrhosis) by multivariate analysis (relative risk: 2.3, P &lt; .01). The mean steatosis (1.6 vs. 2.16, P &lt; .04) and perisinusoidal fibrosis scores (0.35 vs. 0.9, P &lt; .049) were lower in those with low normal (&lt;30 IU/L) ALT versus high normal ALT. However, the prevalence of advanced fibrosis was similar (5 of 15 vs. 13 of 36, respectively). In conclusion, (1) the entire histologic spectrum of NAFLD can be seen in individuals with normal ALT values, (2) the histologic spectrum in these individuals is not significantly different from those with elevated ALT levels, and (3) a low normal ALT value does not guarantee freedom from underlying steatohepatitis with advanced fibrosis.
True transport: One or more sodium-dependent bile acid transporters?
Authors: Roger Lester, Piotr Zimniak
Journal: Hepatology (1993)

Sodium-dependent bile acid transport is a well-established function of the sinusoidal segment of the hepatocyte plasma membrane. Evidence has been provided previously by the authors for the existence of a putative sinusoidal plasma membrane sodium-dependent bile acid transporter with a mass of 49 kD. This protein has been partially characterized with a monoclonal antibody and by reconstitution in proteoliposomes. Further characterization is provided in the paper under discussion. The transporter was isolated from plasma membranes and from endoplasmic reticulum by immunoprecipitation with a monoclonal antibody. The protein was separated from antibody by means of HPLC and SDS-PAGE with electroelution. Amino acid analysis and NH 2 -terminal amino acid sequencing were performed. For both preparations, it was shown that the NH 2 -terminal amino acid sequence was identical, and the amino acid composition was similar to results obtained for the microsomal enzyme epoxide hydrolase. Purified mEH was immunoprecipitated with the monoclonal antibody which precipitated the plasma membrane protein. Isoelectric focusing established that the isoelectric points for epoxide hydrolase and the proteins isolated from the endoplasmic reticulum and plasma membranes were identical. The peptide maps prepared by subjecting the three proteins to enzymatic fragmentation with subtilisin were essentially identical. Because of the known contamination of plasma membrane fractions with endoplasmic reticulum and because of the high specific activity of epoxide hydrolase in endoplasmic reticulum, special attention was devoted to the question of the localization of the enzyme/transporter in plasma membrane. It was possible to show that virtually all of the immunoprecipitated protein obtained from intact cells derived from plasma membrane and that only a small fraction could be explained as having originated in endoplasmic reticulum. Finally, a hydrophobic plot of the amino acid sequence of epoxide hydrolase suggested that the protein contained four potential transmembrane domains. It could be concluded that a/the 49-kD sinusoidal plasma membrane sodium-dependent bile acid transporter protein was closely similar or identical to epoxide hydrolase. In view of the relatively small mass of the protein and its limited number of potential transmembrane domains, it appeared probable that the physiological membrane transporter consists of an assembly of 49-kD monomers or an assembly of heterologous proteins including the 49-kD protein.
Pheochromocytoma Causing Excessive Parathyroid Hormone Production and Hypercalcemia
Authors: SUBHASH C. KUKREJA
Journal: Annals of Internal Medicine (1973)

A young man presented with clinical and laboratory manifestations of pheochromocytoma. He also had hypercalcemia and high serum parathyroid hormone concentrations. Surgical removal of the pheochromocytoma resulted in return of catecholamine, serum calcium, and parathyroid hormone concentrations to normal. The increased catecholamines probably stimulated the parathyroid glands to produce excessive parathyroid hormone, resulting in hypercalcemia.
Genetic Reclassification of Histologic Grade Delineates New Clinical Subtypes of Breast Cancer
Authors: Anna V. Ivshina, Joshy George, Oleg Senko, Benjamin Mow, Thomas C. Putti, Johanna Smeds, Thomas Lindahl, Yudi Pawitan, Per Hall, Hans Nordgren, John E.L. Wong, Edison T. Liu, Jonas Bergh, Vladimir A. Kuznetsov, Lance D. Miller
Journal: Cancer Research (2006)

Abstract Histologic grading of breast cancer defines morphologic subtypes informative of metastatic potential, although not without considerable interobserver disagreement and clinical heterogeneity particularly among the moderately differentiated grade 2 (G2) tumors. We posited that a gene expression signature capable of discerning tumors of grade 1 (G1) and grade 3 (G3) histology might provide a more objective measure of grade with prognostic benefit for patients with G2 disease. To this end, we studied the expression profiles of 347 primary invasive breast tumors analyzed on Affymetrix microarrays. Using class prediction algorithms, we identified 264 robust grade-associated markers, six of which could accurately classify G1 and G3 tumors, and separate G2 tumors into two highly discriminant classes (termed G2a and G2b genetic grades) with patient survival outcomes highly similar to those with G1 and G3 histology, respectively. Statistical analysis of conventional clinical variables further distinguished G2a and G2b subtypes from each other, but also from histologic G1 and G3 tumors. In multivariate analyses, genetic grade was consistently found to be an independent prognostic indicator of disease recurrence comparable with that of lymph node status and tumor size. When incorporated into the Nottingham prognostic index, genetic grade enhanced detection of patients with less harmful tumors, likely to benefit little from adjuvant therapy. Our findings show that a genetic grade signature can improve prognosis and therapeutic planning for breast cancer patients, and support the view that low- and high-grade disease, as defined genetically, reflect independent pathobiological entities rather than a continuum of cancer progression. (Cancer Res 2006; 66(21): 10292-301)
Appendectomy—Surgical History.
Authors: B. Merrill Ricketts
Journal: JAMA (1902)

Cincinnati, Dec. 16, 1901. <h3>To the Editor:</h3> —I thank Dr. Frank Woodbury for calling my attention (The Journal, page 1620, Dec. 14, 1901) to Dr. Thomas G. Morton's case of appendectomy—April 23, 1887. In my investigation Dr. Morton's case was overlooked. It is to be regretted. In this paper, as in all I present, honest criticism is coveted. In the question of priority, I will say that Dr. Stemen of Fort Wayne, Ind., stated to me yesterday that he made a diagnosis of appendicitis, performed a celiotomy and removed the appendix during 1884. I am indeed sorry that these facts did not appear in my paper. Very truly,