ACUTE LUPUS ERYTHEMATOSUS DISSEMINATUS
Authors: Harley E. Cluxton, Louis A. M. Krause
Journal: Annals of Internal Medicine (1943)

Article1 December 1943ACUTE LUPUS ERYTHEMATOSUS DISSEMINATUSHARLEY E. CLUXTON JR., M.D., LOUIS A. M. KRAUSE, M.D., F.A.C.P.HARLEY E. CLUXTON JR., M.D.Search for more papers by this author, LOUIS A. M. KRAUSE, M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-19-6-843 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptIn comparatively recent years much attention has been given to the symptom-complex called acute lupus erythematosus disseminatus. The purpose of this paper is to present a concise review of the literature on this subject with emphasis on its clinical aspects.Synonyms: Visceral erythema group (Osler1), disseminated lupus erythematosus, atypical verrucous endocarditis (Libman-Sacks2), fever of unknown origin (Christian3), and diffuse peripheral vascular disease (Baehr and others4).Definition:Lupus erythematosus disseminatus acutus is a clinical entity even though the name emphasizes only one of several characteristic symptoms of the syndrome. It is a disease of unknown etiology associated with widespread visceral lesions...Bibliography1. OSLER W: The erythema group of skin diseases, Am. Jr. Med. Sci., 1904, cxxvii, 751-754. CrossrefGoogle Scholar2. LIBMANSACKS EB: A hitherto undescribed form of valvular and mural endocarditis, Arch. Int. Med., 1924, xxxiii, 701-737. CrossrefGoogle Scholar3. CHRISTIAN HA: Long continued fever with inflammatory changes in serous and synovial membranes and eventual glomerulonephritis: a clinical syndrome of unknown etiology, Med. Clin. N. Am., 1935, xviii, 1023-1026. Google Scholar4. BAEHRKLEMPERERSCHIFRIN GPA: Diffuse disease of the peripheral circulation (usually associated with lupus erythematosus and endocarditis), Trans. Assoc. Am. Phys., 1935, l, 139-155. Google Scholar5. KAPOSI MK: Neue Beiträge zur Kenntnis des Lupus erythematosus, Arch. f. Dermat. u. Syph., 1872, iv, 36-78. CrossrefGoogle Scholar6. OSLER W: On the visceral complications of erythema exudativum multiforme, Am. Jr. Med. Sci., 1895, cx, 629. CrossrefGoogle Scholar7. FORDYCE JA: Lupus erythematosus in a tuberculous subject, Jr. Cutan. Dis., 1899, xvii, 113-116. Google Scholar8. KEEFERFELTY CAAR: Acute disseminated lupus erythematosus: report of three fatal cases, Bull. Johns Hopkins Hosp., 1924, xxxv, 294-304. Google Scholar9. KIERLAND RR: Classification and cutaneous manifestations of acute lupus, Proc. Staff Meet. Mayo Clin., 1940, xv, 376-377. Google Scholar10. ROSEPILLSBURY EDM: Acute disseminated lupus erythematosus—a systemic disease, ANN. INT. MED., 1939, xii, 951-963. Google Scholar11. GINZLERFOX AMTT: Disseminated lupus erythematosus: a cutaneous manifestation of a systemic disease (Libman-Sacks); report of a case, Arch. Int. Med., 1940, lxv, 26-50. CrossrefGoogle Scholar12. MADDEN JF: Acute disseminated lupus, Arch. Dermat. and Syph., 1932, xxv, 854-875. CrossrefGoogle Scholar13. STEWARDGOECKERMAN CCWH: Lupus erythematosus disseminatus in juveniles, Am. Jr. Dis. Child., 1931, xxxxii, 864-868. Google Scholar14. REIFENSTEINREIFENSTEINREIFENSTEIN ECECGH: A variable symptom complex of undetermined etiology with fatal termination, Arch. Int. Med., 1939, lxiii, 553-574. CrossrefGoogle Scholar15. WEIDMANGILMAN FDRL: A case of acute disseminated lupus erythematosus; necropsy disclosing acute endocarditis but not tuberculosis, Brit. Jr. Dermat. and Syph., 1931, xxxxiii, 641-647. CrossrefGoogle Scholar16. BELOTE GH: Lupus erythematosus disseminatus: its present status, Arch. Dermat. and Syph., 1939, xxxix, 793-806. CrossrefGoogle Scholar17. STOKES JH: The diagnosis of disseminated erythematosus lupus, Med. Clin. N. Am., 1926, x, 290-299. Google Scholar18. O'LEARY PA: Disseminated lupus erythematosus, Minnesota Med., 1934, xvii, 637-644. Google Scholar19. FRIEDBERGGROSSWALLACH CKLK: Non-bacterial thrombotic endocarditis associated with prolonged fever, arthritis, inflammation of serous membranes and widespread vascular lesions, Arch. Int. Med., 1936, lviii, 662-684. CrossrefGoogle Scholar20. TREMAINE MJ: Subacute Pick's disease (polyserositis) with polyarthritis and glomerulonephritis: a report of two fatal cases, New England Jr. Med., 1934, ccxi, 754-759. CrossrefGoogle Scholar21. SLOCUMB CH: Arthralgia and arthritis of lupus, Proc. Staff. Meet. Mayo Clin., 1940, xv, 683-686. Google Scholar22. Cabot Case: New Eng. Jr. Med., 1941, ccxxv, 151-155. Google Scholar23. Cabot Case: New Eng. Jr. Med., 1941, ccxxv, 956-958. Google Scholar24. KEIL H: Dermatomyositis and systemic lupus erythematosus, Arch. Int. Med., 1940, lxvi, 339-383. CrossrefGoogle Scholar25. Cabot Case: New Eng. Jr. Med., 1941, ccxxv, 418-422. Google Scholar26. DAVISAYMAN DD: Subacute bacterial endocarditis with unusual vesiculobullous skin lesions: necropsy reports in 2 cases, Am. Heart Jr., 1927, ii, 671-681. CrossrefGoogle Scholar27. CORBURNPAULI AFRH: Quoted by KEIL.24 Google Scholar28. KLEMPERERPOLLACKBAEHR PADG: Pathology of disseminated lupus erythematosus, Arch. Path., 1941, xxxii, 569-631. Google Scholar29. CONTRATTOLEVINE AWSA: Acute lupus erythematosus disseminatus, report of a case, New Eng. Jr. Med., 1939, ccxxi, 602-604. CrossrefGoogle Scholar30. GROSS L: Cardiac lesions of Libman-Sacks associated with lupus, Am. Jr. Path., 1940, xvi, 375-408. Google Scholar31. GROSS L: Heart in atypical verrucous endocarditis (Libman-Sacks), Libman Anniv., 1932, ii, 527-550. Google Scholar32. STICKNEYKEITH JMNM: Renal involvement in disseminated lupus erythematosus, Arch. Int. Med., 1940, lxvi, 643-660. CrossrefGoogle Scholar33. KEITH NM: Renal problem in disseminated lupus erythematosus, Proc. Staff. Meet. Mayo Clin., 1940, xv, 682-683. Google Scholar34. Cabot Case: New Eng. Jr. Med., 1938, ccxviii, 838-843. Google Scholar35. Cabot Case: New Eng. Jr. Med., 1938, ccxix, 273-277. Google Scholar36. WADSWORTH AB: Quoted by BAEHR ET AL.4 Google Scholar37. MAUMENEE AE: Retinal lesions in lupus erythematosus, Am. Jr. Ophth., 1940, xxiii, 971-981. CrossrefGoogle Scholar38. JARCHO S: Lupus erythematosus associated with visceral vascular lesions, Bull. Johns Hopkins Hosp., 1936, lix, 262-273. Google Scholar39. GOECKERMAN WH: Lupus erythematosus as a systemic disease, Jr. Am. Med. Assoc., 1923, lxxx, 542-547. CrossrefGoogle Scholar40. REITMANNVON ZUMBUSCH KL: Beitrag zur Pathologie des Lupus erythematosus acutus (disseminatus), Arch. f. Dermat. u. Syph., 1910, 147-180. Google Scholar41. LOWLOGANRUTHERFORD RCWRA: A fatal case of lupus erythematosus with autopsy, Brit. Jr. Dermat., 1920, xxxii, 253-262. CrossrefGoogle Scholar42. RAVOGLI A: Lupus erythematosus diffusus unfortunately treated with tuberculin, Jr. Cutan. Dis., 1915, xxxiii, 266-272. Google Scholar43. KEIL H: Relationship between lupus erythematosus and tuberculosis, Arch. Dermat. and Syph., 1933, xxviii, 765-779. CrossrefGoogle Scholar44. ROXBURGH AC: Acute disseminated lupus; five fatal cases, Brit. Jr. Dermat., 1933, xlv, 95-109. CrossrefGoogle Scholar45. O'LEARY PA: Prognosis and treatment of systemic lupus, Proc. Staff. Meet. Mayo Clin., 1940, xv, 686-688. Google Scholar46. PELS IR: Review of lupus erythematosus disseminatus, Internat. Clin., 1933, iv, 273-298. Google Scholar47. APITZ K: Quoted by BAEHR ET AL.4 Google Scholar48. GERBER IE: Quoted by BAEHR ET AL.4 Google Scholar49. PULAY E: Stoffwechselpathologie und Hautkrankheiten, Dermat. Wchnschr., 1921, lxxiii, 1217-1234. Google Scholar50. GENNERICH W: Ueber die Aetiologie des Lupus Erythematodes, Arch. f. Dermat. u. Syph., 1921, cxxxv, 184-207. CrossrefGoogle Scholar51. LUDYCORSON JBEF: Lupus erythematosus—increased incidence, hematoporphyrinuria and spectroscopic findings, Arch. Dermat. and Syph., 1933, xxxvii, 403-416. Google Scholar52. LEWIS T: Quoted by KEIL.54 Google Scholar53. WILSON JF: Sulfanilamide treatment of acute lupus, failure with well controlled administration, Arch. Dermat. and Syph., 1939, xl, 241-243. CrossrefGoogle Scholar54. KEIL H: Conception of lupus erythematosus and its morphologic variants, with particular reference to "systemic" lupus erythematosus, Arch. Dermat. and Syph., 1937, xxxvi, 729-757. CrossrefGoogle Scholar55. KEITHROWNTREE NMLG: A study of the renal complications of disseminated lupus erythematosus: report of four cases, Trans. Assoc. Am. Phys., 1922, xxxvii, 487-502. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Baltimore, Maryland*Received for publication August 1, 1942.From the Department of Medicine, Baltimore City Hospitals.†Fellow in Medicine, the Mayo Clinic. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byAudiovestibular manifestations of the antiphospholipid syndromeDoes corticosteroid therapy affect the survival of patients with systemic lupus erythematosus?Psychopathology in systemic lupus erythematosus. II. 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NELSONThe Bone Marrow as a Diagnostic Aid in Acute Disseminated Lupus ErythematosusAnnouncement11Received for publication January 6, 1948.The electrocardiogram in lupus erythematosus disseminatus 1 December 1943Volume 19, Issue 6Page: 843-872KeywordsEndocarditisErythemaEtiologyFever of unknown originHospital medicineLesionsLupus erythematosusPeripheral vascular diseaseSystemic lupus erythematosus ePublished: 1 December 2008 Issue Published: 1 December 1943 PDF downloadLoading ...