tbuckley/cabot-search huggingface dataset:
Physicians Advising Investment Firms
Authors: Michael A Patmas
Journal: JAMA (2005)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Towards a more specific therapy: targeting nonmelanoma skin cancer cells
Authors: R.M. Szeimies, S. Karrer
Journal: British Journal of Dermatology (2006)

Epithelial cancers of the skin, e.g. basal cell carcinoma and squamous cell carcinoma, are the most common tumours in humans with increasing incidence. Hence the development of new therapeutic strategies is of utmost interest. For many years the most often used conventional therapies for these diseases were surgical procedures such as curettage and electrodesiccation, excision or, with so far the best outcome in terms of remission rates, micrographic surgery. Other ablative treatment modalities are cryotherapy, radiation therapy or the use of lasers (Er:YAG, CO2). All those above‐mentioned treatments have in common that they are quite unspecific and do not target the tumour itself or its environment, thus leading to unwanted effects in the surrounding tissue such as scar formation or other cosmetically disfiguring events. Therefore, the development of novel, more pathogenesis‐based therapies such as the use of retinoids, cyclooxygenase inhibitors, topical immunomodulators, inhibitors of the sonic‐hedgehog signalling pathway or photodynamic therapy are challenging new approaches.
Abstract P121: Meta-analysis of the Randomized Controlled Trials of Sodium Intake Reduction and Urinary Albumin Excretion
Authors: Pasquale Strazzullo, Lanfranco D'Elia, Michele Schiano di Cola, Ivana Savino, Clementina Iannotta, ferruccio Galletti
Journal: Circulation (2014)

Background: Urinary albumin excretion (UAE) is a predictor of chronic kidney disease and of higher cardiovascular morbidity and mortality. A number of studies investigated the effect of reduced dietary sodium intake on UAE but their results were not consistent. Therefore, our study assessed the effect of sodium restriction on UAE and/or on albumin/creatinine ratio (ACR) through an updated meta-analysis of the available randomised controlled trials (RCT). Methods: A systematic search of the on-line databases was conducted including RCTs that assessed UAE/ACR at the start and the end of the trial and outcomes expressed as difference between the effect of two different sodium intake regimens. For each study, the mean difference (MD) and 95% confidence intervals (95%CI) were extracted and pooled using a random effect model. Heterogeneity, publication bias, subgroup, and meta-regression analyses were performed. Results: Nine studies were identified, providing 21 cohorts with overall 454 participants and 1-6 weeks follow-up time. In the pooled analysis, lower sodium intake was associated with a 26.7% (95% CI: -40.7 to -12.6) reduction of UAE, with no evidence of publication bias.The effect of lower sodium intake was highest in the cohorts including patients on concomitant RAAS-blocking therapy (-37.7%; -56.5 to -19.9), in those with intervention lasting at least 2 weeks (-32.4%; -47.2 to -17.7), and among participants with evidence of kidney damage (-32.6%; -47.5 to -17.6). The changes in BP occurring during intervention were a significant source of heterogeneity. &gt;The analysis of changes in ACR, where available, provided similar results. Conclusions: This meta-analysis indicated that sodium intake reduction markedly reduces albumin excretion, more so among patients with hypertension and/or kidney damage and during concomitant RAAS-blocking therapy.
Abstract 14641: Deficiency in the E3 Ubiquitin Ligase Parkin Exacerbates Alcoholic Cardiomyopathy: Role of Mitophagy
Authors: Xihui Xu, Jun Ren
Journal: Circulation (2014)

Background: Long-term heavy alcohol consumption has been shown to promote mitochondrial injury, unfavorable geometric and contractile changes in the heart. Parkin, a cytosolic E3 ubiquitin ligase encoded by PARK2 gene, plays an important role in the regulation of selective mitophagy. This study was designed to examine the role of Parkin in alcohol-induced myocardial injury (aka alcoholic cardiomyopathy) and the underlying mechanism with a focus on mitophagy. Methods: Adult male wild-type C57 and PARKIN2 knockout (Parkin-/-) mice were placed on alcohol (4%) or control diet for 4 weeks. Echocardiographic and cardiomyocyte mechanical properties were assessed. Mitochondrial morphology, function and mitophagy were examined using transmission electronic microscopy, Clark-type oxygen electrode, and Western blot, respectively. Results: Our results revealed that chronic alcohol consumption triggered unfavorable geometric and contractile changes [decreased fractional shortening (FS) and ejection fraction (EF), with enlarged left ventricular chamber; decreased peak shortening (PS) and velocity of shortening +dL/dt, increased time-to-90% relengthening TR90], the effects of which were exacerbated by Parkin deficiency. In addition, our data showed that chronic alcohol intake promoted myocardial mitochondrial swelling with cristae disarrangement, induced myocardial mitochondrial depolarization and respiration inhibition, which were exacerbated by Parkin knockout. Furthermore, chronic alcohol consumption promoted mitophagy activation, as evidenced by accumulation of Parkin and LC3BII in mitochondria and mitochondrial ubiquitination level in the heart, the effect of which was nullified by Parkin knockout. Conclusion: These data suggest that chronic alcohol consumption triggered mitophagy by stimulating Parkin translocation to the mitochondria, which may be an adaptive response in the heart. Our findings implicated the therapeutic potential of mitophagy as a target in the management of alcoholic cardiomyopathy.
Comment on “deferiprone versus deferoxamine in thalassemia intermedia: Results from a 5‐year long‐term <scp>I</scp>talian multicenter randomized clinical trial”
Authors: Antoine N. Saliba, Ali T. Taher
Journal: American Journal of Hematology (2015)

We read with interest the article by Calvaruso et al. reporting on the long-term efficacy and safety of deferiprone (DFP) as compared to deferoxamine (DFO) in patients with thalassemia intermedia (TI) 1. Although this clinical trial was registered prior to the availability of results from the THALASSA study 2, we would like to point out that the design of studies evaluating the efficacy of iron chelators in non-transfusion-dependent thalassemia (NTDT) should include a comparison with deferasirox (DFX), the current gold-standard for iron chelation in this group of thalassemias. The doses of DFP (75 mg/kg/day daily) and DFO (50 mg/kg/day for 5 days per week) used in this trial are based on the usual doses in transfusion-dependent thalassemia (TDT). These doses may not be ideal in NTDT, since DFX doses needed to achieve adequate chelation were lower in NTDT than in TDT 2. In addition, the transfusion requirements of both groups of TI patients, as reported in Table 1, are higher than the usual requirements of TDT patients. As the pathophysiology and clinical complications of NTDT differ from TDT, and as many patients with TI may be transfusion-dependent later in their life, the ideal study design should include transfusion requirements and make sure that patients are phenotypically similar from that standpoint 3. The authors tried to account for transfusion requirements through the generalized linear mixed effects model; however, in order to be able to extrapolate the results of the trial to the clinical setting, study design should categorize patients according to transfusion requirements before inclusion. Concerning the primary endpoint of the trial, randomized controlled trials assessing the efficacy of iron chelation therapy should have the change in liver iron concentration (LIC) by magnetic resonance imaging (MRI) as a primary endpoint. LIC by MRI is a safe and reliable means to assess iron overload in NTDT. LIC should also be part of the inclusion criteria, in addition to or instead of serum ferritin, which may underestimate iron burden in NTDT and fluctuate with inflammation 4. The manuscript reports a similar proportion of patients with serum ferritin ≤ 400 ng/mL in both the DFP and DFO groups. This cutoff is not supported by the available literature. The literature suggests that 300 ng/mL is an appropriate cutoff to discontinue iron chelation therapy as none of the patients have NTDT-related complications below that cutoff 4, 5. A final point to be taken into consideration when interpreting the results of the trial is the high 5-year attrition rate, which may limit the reliability of the results. Antoine N. Saliba, Ali T. Taher* Division of Hematology/Oncology, Department of Internal Medicine, American University of Beirut, Beirut, Lebanon
Antihypertensive Agents and Cardiovascular Events in Patients With Coronary Disease and Normal Blood Pressure—Reply
Authors: Steven E. Nissen
Journal: JAMA (2005)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Effect of Phenazine di-&lt;italic&gt;N&lt;/italic&gt;-oxide and Phenazine on Total Cellular Dry Mass of Mouse Ehrlich Ascites Cells as Measured by Interference Microscopy&lt;xref ref-type="fn" rid="FN1"&gt;2&lt;/xref&gt;
Authors: Hun Lee, Victor Richards, Arthur Furst
Journal: JNCI Journal of the National Cancer Institute (1961)

Eighteen Swiss-Webster mice were inoculated with equal quantities of Ehrlich ascitic fluid and divided into 3 groups of 6 animals each. The first group was untreated as control. The second group was treated with phenazine, a chemical which has little effect on Ehrlich ascites tumor, as a negative control. The third group was treated with phenazine di-N-oxide, a newly reported carcinostatic agent derived from phenazine. Cell samples were taken daily for cellular dry-mass measurements with interference microscopy. All the phenazine di-N-oxide-treated animals responded to the treatment with a quick and progressive increase in cellular dry mass and size and with the number of a certain type of small cells. Two of the animals in the phenazine-treated group showed similar, but much milder, reactions to the treatment. The control group showed no such reaction.
Early Outcome of a Randomized Comparison of Off-Pump and On-Pump Multiple Arterial Coronary Revascularization
Authors: Junjiro Kobayashi, Tadashi Tashiro, Masami Ochi, Hitoshi Yaku, Go Watanabe, Toshihiko Satoh, Osamu Tagusari, Hiroyuki Nakajima, Soichiro Kitamura
Journal: Circulation (2005)

Background— Previous randomized comparisons of off-pump and on-pump coronary artery bypass grafting (CABG) have yielded controversial results about the cardiac and neurological events and graft patency. In addition, these randomized studies were composed of CABG with a few arterial grafts. We performed a prospective randomized controlled study to compare off-pump and on-pump CABG with multiple arterial grafts. Methods and Results— Between July, 2002, and September, 2004, 167 consecutive unselected patients referred for elective primary CABG were randomly assigned to undergo multiple arterial off-pump CABG (n=81) or on-pump CABG (n=86). The clinical outcomes and S-100 protein, neuron-specific enolase, and maximum creatine kinase-MB levels were compared. Early graft patency was examined within 3 weeks after the operation by angiography. The number of grafts performed per patient (3.5±1.0 for off-pump CABG and 3.6±0.9 for on-pump CABG) and the number of arterial grafts performed per patient (3.3±1.0 for off-pump CABG and 3.4±0.9 for on-pump CABG) were similar. Completeness of revascularization (completed grafts/planned grafts) was 98% in both procedures. There were no hospital deaths in either group. The operation time was significantly ( P &lt;0.001) shorter in the off-pump group than in the on-pump group (267±60 minutes versus 307±59 minutes). The incidence of perioperative complications was similar. The frequency of no need for transfusion was higher in the off-pump group than in the on-pump group (80% versus 55%, P &lt;0.001). The S-100 protein levels at the admission into the intensive care unit were significantly ( P &lt;0.001) lower in the off-pump group than in the on-pump group (0.20±0.11 ng/mL versus 0.34±0.22 ng/mL). The neuron-specific enolase levels at the intensive care unit admission were significantly ( P &lt;0.001) lower in the off-pump group than in the on-pump group (10.4±9.0 ng/mL versus 16.9±6.9 ng/mL). Maximum creatine kinase-MB levels were significantly ( P =0.046) lower in the off-pump group than in the on-pump group (17.1±16.7 IU/L versus 21.5±10.6 IU/L). The overall early graft patency rate with or without stenosis was the same (98%) in both groups, but the rate without stenosis was slightly worse in the off-pump group (93%) than in the on-pump group (96%) ( P =0.093). The stenosis-free patency rate in the right coronary area was significantly ( P =0.028) worse in the off-pump CABG group (90%) than in the on-pump group (99%). Conclusions— Off-pump CABG with multiple arterial grafts was as safe as the conventional on-pump CABG, with similar completeness of revascularization and early graft patency.
Interferon-α in the generation of monocyte-derived dendritic cells: recent advances and implications for dermatology
Authors: Á. Farkas, L. Kemény
Journal: British Journal of Dermatology (2011)

Journal Article Interferon‐α in the generation of monocyte‐derived dendritic cells: recent advances and implications for dermatology Get access Á. Farkas, Á. Farkas Department of Dermatology and Allergology, University of Szeged, 6720 Szeged, Hungary Árpád Farkas. E‐mail: farkas@mail.derma.szote.u‐szeged.hu or farkas_arpad@yahoo.com Search for other works by this author on: Oxford Academic Google Scholar L. Kemény L. Kemény Department of Dermatology and Allergology, University of Szeged, 6720 Szeged, HungaryDermatological Research Group of the Hungarian Academy of Sciences and the University of Szeged, Szeged, Hungary Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 165, Issue 2, 1 August 2011, Pages 247–254, https://doi.org/10.1111/j.1365-2133.2011.10301.x Published: 01 August 2011
Drug-induced subacute cutaneous lupus erythematosus: evidence for differences from its idiopathic counterpart
Authors: A.V. Marzano, R. Lazzari, I. Polloni, C. Crosti, P. Fabbri, M. Cugno
Journal: British Journal of Dermatology (2011)

Drug-induced subacute cutaneous lupus erythematosus (DI-SCLE) is a lupus variant with predominant skin involvement temporally related to drug exposure and resolving after drug discontinuation. It usually presents with annular polycyclic or papulosquamous eruptions on sun-exposed skin and shows serum anti-Ro/SSA antibodies.To address the question whether DI-SCLE differs significantly from idiopathic SCLE by virtue of clinical features.Ninety patients with SCLE seen in our departments from 2001 to 2010 were reviewed. Eleven of them diagnosed as having DI-SCLE were evaluated for type of skin lesions, systemic involvement, clinical course, and histopathological, direct immunofluorescence and laboratory findings. The cutaneous features were compared with those of the 79 patients with idiopathic SCLE.The cutaneous picture was widespread in 82% of patients with DI-SCLE and in 6% of those with idiopathic SCLE [odds ratio (OR) 66·6, 95% confidence interval (CI) 11·2-394·9; P = 0·0001]. Bullous and erythema multiforme (EM)-like lesions were present in 45% of patients with DI-SCLE and in 1% of those with idiopathic SCLE (OR 65·0, 95% CI 6·5-649·6; P = 0·0001). Vasculitic lesions were observed in 45% of patients with DI-SCLE and in 3% of those with idiopathic SCLE (OR 32·1, 95% CI 5·1-201·7; P = 0·0001). Malar rash occurred in 45% of patients with DI-SCLE and in 6% of those with idiopathic SCLE (OR 12·3, 95% CI 2·8-54·9; P = 0·001). Visceral manifestations were excluded in all patients with DI-SCLE. Anti-Ro/SSA antibodies were found in all but one patient with DI-SCLE and disappeared after resolution in 73% of cases.DI-SCLE differs from idiopathic SCLE by virtue of distinctive cutaneous features, particularly the widespread presentation and the frequent occurrence of malar rash and bullous, EM-like and vasculitic manifestations.
Repopulation of Hematopoietic Tissues and Blood in Lethally X-Irradiated Mice by Homologous Bone-Marrow Cells&lt;xref ref-type="fn" rid="FN1"&gt;2&lt;/xref&gt;
Authors: Ruth M. Merwin, Charles C. Congdon
Journal: JNCI Journal of the National Cancer Institute (1957)

Repopulation of Hematopoietic Tissues and Blood in Lethally X-Irradiated Mice by Homologous Bone-Marrow Cells Get access Ruth M. Merwin, Ruth M. Merwin National Cancer Institute4, Bethesda, Maryland, and Biology Division, Oak Ridge National Laboratory5, Oak Ridge, Tennessee Search for other works by this author on: Oxford Academic PubMed Google Scholar Charles C. Congdon Charles C. Congdon National Cancer Institute4, Bethesda, Maryland, and Biology Division, Oak Ridge National Laboratory5, Oak Ridge, Tennessee Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 19, Issue 5, November 1957, Pages 875–884, https://doi.org/10.1093/jnci/19.5.875 Published: 01 November 1957 Article history Received: 20 May 1957 Published: 01 November 1957
Abstract 9413: A Periodontal Pathogen Promotes Neointimal Formation after Arterial Injury Through Toll-Like Receptor-2 Signaling
Authors: Naho Kobayashi, Jun-Ichi Suzuki, Masahito Ogawa, Norio Aoyama, Yasunobu Hirata, Ryozo Nagai, Yuichi Izumi, Mitsuaki Isobe
Journal: Circulation (2011)

Introduction-- Inflammatory response plays an important role in neointimal formation after an arterial injury. Previous studies demonstrated that periodontal bacteria were detected in atheromatous plaques, however, little is known about the effects of periodontal infection on vascular remodeling after mechanical injury. Toll-like receptors (TLRs) are key receptors of virulence factors of many periodontal bacteria. Hypothesis-- We assessed the hypothesis that TLR-2 plays a pivotal role in a periodontopathic bacteria-induced neointimal formation after an arterial injury. Methods-- Each mouse was implanted with a chamber subcutaneously. The chamber was used to inject bacterial infection into the mice. Two weeks after the chamber implantation, femoral arteries were injured and Porphyromonas gingivalis (P.g.), one of the major periodontopathic bacteria, or vehicle was injected once per week into the chamber. Fourteen days after the arterial injury, the murine femoral arteries were obtained for histopathological and immunohistochemical analyses. Results-- In WT mice, the anti-P.g. IgG antibody level in plasma samples of the P.g.-injected group significantly increased compared to the vehicle injection group (6.5 ± 1.2-fold vs. vehicle injected group, p &lt; 0.05). Histopathological analysis detected that the intima/media thickness ratio (I/M ratio) in the P.g.-injected group (4.54 ± 0.94, n = 11) significantly increased in comparison to the vehicle-injected group (2.31 ± 0.35, n = 11, p &lt; 0.05). Immunohistochemical analysis detected that the P.g.-injected group showed more MCP-1 positive cells (29.0 ± 8.8 cells, n = 5) in the neointimal area compare to the vehicle-injected group (4.6 ± 1.9 cells, n = 5, p &lt; 0.05). It is noteworthy that TLR-2 deficiency negated (1.74 ± 0.36, n = 10) P.g.-induced neointimal formation compared to the WT mice (4.54 ± 0.94, n = 11, p &lt; 0.05). In TLR-2KO mice, I/M ratio in the P.g.-injected group (1.74 ± 0.36, n = 10) was comparable to the vehicle-injected group (1.54 ± 0.37, n = 6). Conclusions-- These findings demonstrate that infection with P.g. could promote neointimal formation after an arterial injury through TLR-2 signaling.
and Functional Significance in the NewClassification of Primary Liver Cancers
Authors: Regina Cheuk-lam Lo, Irene Oi-lin Ng
Journal: Liver Cancer (2013)

Hepatic progenitor cells (HPCs) are bipotential cells residing in normal liver. Their proliferation is observed in reactive conditions of the liver and in primary liver cancers. The observation that some hepatocellular carcinomas (HCCs) express a biliary-like immunophenotype has led to the identification of HPCs in HCC. Accumulating evidence suggests that HPCs play a role as the cell of origin in a variety of primary liver cancers. This has led to the development of revolutionary concepts in hepatocarcinogenesis. In this article, the role and significance of HPCs in HCC, including its classification, are summarized and discussed.