THE PATHOLOGY OF SICKLE CELL DISEASE
Authors: Robert C. Murphy, Shepard Shapiro
Journal: Annals of Internal Medicine (1945)

Article1 September 1945THE PATHOLOGY OF SICKLE CELL DISEASEROBERT C. MURPHY JR., M.D., SHEPARD SHAPIRO, M.D.ROBERT C. MURPHY JR., M.D., SHEPARD SHAPIRO, M.D.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-23-3-376 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe incidence of the sickle cell trait among North American Negroes has been estimated from various surveys to be 7 per cent,237.2 per cent,109.1 per cent6aand even as high as 13 per cent1aof the Negro population. Clinical sickle cell disease appears in an undetermined fraction of cases in which the trait is present, estimates of this ratio varying from 1:7 to 1:40.23As far as can be determined the trait is transmitted as a true Mendelian dominant,12, 15, 23, 33independent of the inheritance of blood type.23This apparent fact has been used as an argument...Bibliography1. BAUER J: Sickle cell disease, Arch. 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