tbuckley/cabot-search huggingface dataset:
Abstract 16278: {beta}3 Adrenergic Stimulation Protects Against eNOS Uncoupling, Oxidative Na+-K+ Pump Inhibition and Vascular Dysfunction in Type 2 Diabetes
Authors: Keyvan Karimi Galougahi, Chia-Chi Liu, Natasha A Fry, Alvaro Garcia, Clare L Hawkins, Helge H Rasmussen, Gemma A Figtree
Journal: Circulation (2012)
Abstract 3339: Effects of Atorvastatin 10 mg versus 40 mg in Eight Months Follow-up Coronary Flow Reserve and Clinical Events in Patients with Acute Myocardial Infarction
Authors: Soon Jun Hong, Seung Cheol Choi, Jong Il Choi, Hyung Joon Joo, Seung Yong Shin, Wan Joo Shim, Seong Mi Park, Sang Yup Lim, Do-Sun Lim
Journal: Circulation (2007)

Background: Circulating bone marrow-derived stem cells are capable of homing to sites of myocardial infarction and endothelial disruption, thereby restoring myocardial function and microvascular integrity after acute myocardial infarction. We compared the effects of atorvastatin 10 mg versus 40 mg in follow-up clinical events and in restoring coronary flow reserve (CFR) during the 8 months follow-up in patients with acute myocardial infarction. Methods: CFR, which is reflective of the integrity of coronary microvasculature, was measured by using intracoronary Doppler wire in 102 consecutive patients with acute myocardial infarction 5 days after the successful primary coronary intervention with sirolimus-eluting stents. Stented patients were randomly assigned to either atorvastatin 10 mg (ATOR10, n=52) or atorvastatin 40 mg (ATOR40, n=50). All patients received aspirin and clopidogrel. Clinical events such as death, myocardial infarction, and target lesion revascularization (TLR) were compared during the 8-month follow-up. Results: CFR increased significantly in both groups during the 8 months follow-up (1.9 ± 0.6 at baseline vs. 2.6 ± 0.7 at follow-up in the ATOR10, p&lt;0.05; 1.9 ± 0.7 at baseline vs. 2.9 ± 0.8 at follow-up in the ATOR40, p&lt;0.05). The changes from baseline in CFR was greater in the ATOR40 Group compared with the ATOR10 Group (1.0 ± 0.8 vs. 0.7 ± 0.6, p&lt;0.05, respectively). The numbers of CD34+ and CXCR4+ cells were significantly greater in the ATOR40 Group compared with the ATOR10 Group (13 ± 10 vs. 6 ± 6, p&lt;0.05, respectively for CD34 cells and 15 ± 14 vs. 10 ± 9, p&lt;0.05, respectively for CXCR4+ cells per 1uL). Clinical events such as death (0 patient in the ATOR10 vs. 2 patients in the ATOR40, p=0.247), myocardial infarction (2 patients in the ATOR10 vs. 1 patient in the ATOR40, p=0.557), and TLR (2 patients in the ATOR10 vs. 2 patients in the ATOR40, p=0.692) demonstrated no significant differences during the follow-up. Conclusion: The increases from baseline in CFR, CD34+ cells and CXCR4+ cells were significantly greater in the ATOR40 Group compared with the ATOR10 Group. However, the improvement in left ventricular systolic function and the rate of clinical events revealed no significant differences between the 2 groups.
Abstract 17052: Multiparametric Noninvasive Assessment of Left Ventricular Filling Pressures: Are We There Yet?
Authors: Zoran Popovic, Kazuaki Negishi, Alan L Klein, Jamsed D Thomas, Thomas H Marwick
Journal: Circulation (2011)

Background: Several echo parameters have been proposed as surrogates of LV filling pressures, but their comparative and additive values are unknown. Recent American Society of Echocardiography/European Association of Echocardiography (ASE/EAE) recommendations have proposed a multiparametric algorithm to predict LV filling pressures in the setting of preserved or decreased LV ejection fraction (EF). Our aim was to compare discriminative ability of individual parameters used in ASE/ESE algorithm and validate its use in a large cohort of patients. Methods: We assessed 449 consecutive pts (181 women, age 63±13y) in whom echocardiography and invasive measurement of LV end-diastolic pressure (EDP) were performed within 24 hours. Elevated EDP was defined as ≥20 mmHg, and decreased EF was defined as &lt;0.5. Predictive ability of individual parameters was compared by using area under the curve (AUC) obtained by receiver operator characteristic analysis. Finally, multiple parameters (see Table for list) were combined first in ASE/EAE algorithm, and then in a new Classification and Regression Tree (CART)-derived algorithm. Results: LV EDP was elevated in out 80/331 pts with normal EF, and in 47/118 pts with decreased EF. AUC values were higher in decreased EF pts, with E/E', LAVI, and PASP being significant in both groups (Table 1). Sensitivity and specificity of ASE/ESE algorithm to detect elevated EDP were 74% and 57% in patients with normal EF, and 78% and 59% in patients with decreased EF, while they were 73% and 76% in patients with normal EF and 77% and 80% in patients if CART-derived algorithm was used. Conclusion: While most echo parameters tested show discriminative ability to assess LV filling pressures, their predictive power is low. Their combined use in ASE/EAE algorithm shows moderate sensitivity but poor specificity in this series of pts. Specificity can be moderately improved by the use of the CART algorithm.
Abstract 14440: Statin Can Reduce Stent Thrombosis After Stent Implantation In Acute Myocardial Infarction Patients With High Level of Inflammatory Marker
Authors: Hae Chang Jeong, Youngkeun Ahn, Myung Ho Jeong, Young Jo Kim, Shung Chull Chae, Myeong Chan Cho, Jei Keon Chae, Chong Jin Kim
Journal: Circulation (2011)

Introduction: It has been reported that stent thrombosis (ST) is accelerated in acute inflammatory status and statin therapy can reduce thrombosis as a pleotrophic anti-inflammatory effect. Hypothe...
Abstract 4962: Influence of Adiposity on Carotid Wave Reflection and Arterial Stiffness: A Longitudinal Study in Healthy Children
Authors: Satoru Sakuragi, Richard D Telford, Walter P Abhayaratna
Journal: Circulation (2009)

Background: The relationship between childhood obesity and adverse cardiovascular outcomes during adulthood may be mediated through the promotion of impaired vascular function. Wave reflection is an index of arterial function that is determined by arterial stiffness and is predictive of adverse cardiovascular events in adults. We hypothesized that baseline and changes in adiposity during childhood have an adverse influence on future levels of wave reflection and arterial stiffness. Methods: In 514 healthy children (mean age 8.3±0.4, 50% boys); percentage body fat (%BF) was quantitated by dual-energy x-ray absorptiometry during a baseline assessment in 2005 and during a follow-up assessment in 2007. Baseline insulin resistance was evaluated using a homeostasis model assessment (HOMA-IR). Cardiorespiratory fitness (CRF) was assessed using a 20 meter shuttle run. Carotid artery wave reflection and carotid-femoral pulse wave velocity (PWV) was assessed in 2007 using applanation tonometry (SphygmoCor, Atcor Medical, Sydney, Australia). The second peak of carotid systolic blood pressure (SBP2) was obtained from the carotid arterial waveform. Results: In univariable analysis, baseline %BF was positively associated with carotid SBP2 and PWV measured in 2007. In multivariable analysis, baseline %BF and change in %BF was associated with carotid SBP2 after adjustment for age, sex, baseline blood pressure, heart rate, height, HOMA-IR, total cholesterol and CRF (Table ). Baseline %BF was also independently associated with PWV (Table ). Conclusion: Baseline adiposity was positively related to future carotid wave reflection and arterial stiffness. In addition, subsequent increase in adiposity over a 2-year period was associated a greater degree of wave reflection. Relationship between baseline and change in percent body fat and future wave reflection (carotid SBP2) and arterial stiffness (PWV) in multivariate models
Abstract 14164: Coenzyme Q10 Rescues Diastolic Dysfunction, Cardiomyocyte Hypertrophy and Cardiac Fibrosis in Female db/db Type 2 Diabetic Mice
Authors: Karina Huynh, Marissa A Bowden, Helen Kiriazis, Xiao-Jun Du, Karin A Jandeleit-Dahm, Josephine Forbes, Julie R McMullen, Rebecca H Ritchie
Journal: Circulation (2010)

Diabetic cardiomyopathy is characterised by early diastolic dysfunction and adverse LV remodeling (hypertrophy and fibrosis). We have previously shown that the progression of LV remodeling is similar in male and female diabetic db/db mice. Increased reactive oxygen species and/or reduced antioxidant defences have been implicated in the development of diabetic cardiomyopathy. The present study aimed to elucidate whether administering the endogenous antioxidant Coenzyme Q10 (CoQ) attenuates LV dysfunction and remodeling in a female mouse model of Type 2 diabetes. Non-diabetic db/+ and diabetic db/db 6wk old mice had solubilised CoQ (10mg/kg/day) added to their drinking water for 10wks. LV function was assessed by echocardiography and micromanometry; results were compared to untreated db/+ and db/db controls (n=11–13 mice/group). Untreated female db/db mice exhibited increases in body weight, lipid peroxidation, triglyceride and free fatty acid levels (see table). This was associated with diastolic dysfuncti...
Abstract 1824: The Longevity Factor, SIRT3 Deacetylase Protects Cardiomyocytes From Stress-mediated Cell Death By Deacetylation of Ku-70
Authors: Mahesh P Gupta, Nagalingam R Sundaresan, Sadhana Samant, Senthilkumar Rajamohan, Vinodkumar Pillai, Madhu Gupta
Journal: Circulation (2008)
Abstract 3368: Assessing Aortic Valve Area in Aortic Stenosis by Continuity Equation: A Novel Approach using Real-time Three Dimensional Echocardiography
Authors: Kian Keong Poh, Robert A Levine, Miguel Chaput, Jose Luis Guerrero, Mary Flaherty, Yue-Jian Kang, Eleanor L Morris, Jorge Solis, Berthold Klas, Judy Hung
Journal: Circulation (2006)
Secondary Acute Myelogenous Leukemia in Patients with Retinoblastoma
Authors: Dan S. Gombos, John Hungerford, David H. Abramson, Judith Kingston, Guillermo Chantada, Ira J. Dunkel, Celia B.G. Antoneli, Mark Greenwald, Barret G. Haik, Carlos A. Leal, Aurora Medina-Sanson, Amy C. Schefler, Gavivann Veerakul, Regina Wieland, Norbert Bornfeld, Mathew W. Wilson, Christopher Bing On Yu
Journal: Ophthalmology (2007)
Abstract 015: Very-High Levels of HDL-C and Risks for CHD: The Lifetime Risk Pooling Project
Authors: John T Wilkins, Hongyan Ning, Alan R Dyer, Donald M Lloyd-Jones
Journal: Circulation (2012)

Background: Whereas observational cohort data suggest the association between HDL-C and coronary heart disease (CHD) is inverse and linear, data are sparse at HDL-C values &gt; 80mg/dL. Methods: We therefore pooled data from the NHLBI public-funded datasets of the Framingham, Framingham Offspring, and Atherosclerosis Risk in Communities studies. We used multivariable Cox Proportional-Hazards Models to adjust for age, systolic blood pressure, body mass index, smoking status, prevalent diabetes, non-HDL-C, antihypertension and lipid medication use. We calculated adjusted hazard ratios (HR) to assess the association between a priori strata of HDL-C (&lt;30; &gt;30-40; &gt;40-50; &gt;50-60; &gt;60-70; &gt;70-80; &gt;80mg/dL) and CHD death and non-fatal myocardial infarction using HDL-C &gt;40-50mg/dL as the referent. Results: Over 118,716 person*years of follow up, there were 562 events in 9,226 participants. As expected, hazard ratios for CHD events are greatest in the lowest category of HDL-C (HR 1.68, 95%CI: 1.31, 2.21) and there was generally a stepwise inverse trend in CHD hazards up to 80mg/dL. (See Figure) At HDL-C &gt; 80mg/dL the hazard point estimate for CHD events was insignificantly higher (HR 0.52, 95% CI 0.29, 0.95) than the hazard observed at HDL-C &gt;70-80mg/dl (HR 0.35, 95% CI 0.18-0.66). However, the hazard for CHD events for HDL-C &gt; 80mg/dL was still significantly lower than the referent. Conclusions: These data suggest that the association between HDL-C and CHD risk may not be inverse and linear at HDL-C values &gt; 80mg/dL. These data support investigation into qualitative differences in HDL molecules in individuals with very high levels of HDL-C.
Abstract 2137: Relationship between Duration of Basal QRS Complex and Effectiveness of Antitachycardia Pacing in Implantable Cardioverter-Defibrillator Patients
Authors: Javier Jimenez-Candil, Jose Moriñigo, Maria Ruiz Olgado, Claudio Ledesma, Cándido Martín-Luengo
Journal: Circulation (2008)

In re-entrant Monomorphic Ventricular Tachycardias (MVT), the ability of Antitachycardia Pacing (APT) to terminate the arrhythmia depends on the presence of an excitable gap (EG) and on the capability of the impulses to penetrate this EG. The main limiting factor for penetrating the EG is the distance and the obstacles between pacing site and circuit. Therefore, the duration of basal QRS complex (QRSd), as marker of left ventricle size, fibrosis and/or necrosis, could be related to the efficacy of ATP. Our aim is to determine the relationship between QRSd and the effectiveness of ATP in terminating MVT. In this prospective study we included 200 ICD patients with substrate for presenting MVT (LVEF: 31±11; pacing site: right ventricular apex). Detection and ATP therapies for MVT were programmed as follows: a) Fast-MVT : Cycle Length (CL): 250 –320 ms; 1 burst of 5 pulses at 84 % of CL, and: b) Slow MVT: CL &gt; 320 ms; 3 bursts of 15 pulses at 91%. QRSd was determined on the surface ECG (50 mm/s) inmediatly before the device implant. During a follow-up of 602±368 days, 546 MVT (CL: 329±35 ms; fast MVT: 41 %; QRSd: 111±25 ms) were recorded in 64 patients. Overall success rate of APT was: 87%. MVT terminated with ATP were associated with QRSd values significantly lower: 109±24 vs. 121±29 (p&lt;0.001). After classifying the events into 3 groups according to the QRSd tertiles (≤100, 101–119, ≥120 ms), the frequency of successful ATP (S-ATP) was higher in the first tertile: 96% vs. 80% (Odds Ratio: 5.8; 95% Confidence Interval: 2.9- 11.6; p&lt;0.001). In a multivariate analysis which included LVEF, aetiology, indication, functional class, CL of MVT, beta-blocker therapy (mgs/day) and left ventricle end-diastolic diameter, QRSd (ms) remained as an independent predictor of S-ATP: Odds Ratio: 0.96 (95% Confidence Interval: 0.94 – 0.97; p&lt;0.001). Patients with lower values of QRSd presented higher rates of S-ATP (mean±standard deviation): 98±4 (QRSd≤100) vs. 81±26 (QRSd: 101–120) vs. 72±40 (QRSd&gt;120); p=0.01 (ANOVA). Among ICD patients, the duration of QRS complex is related to the effectiveness of ATP: for each ms of QRSd the adjusted probability of ATP terminating the episode decreases 4 points. Patients with QRSd≤100 ms have significantly higher rates of S-ATP.
Abstract 560: Peri-coronary Epicardial Adipose Tissue Affects Coronary Atherosclerosis In Patients With Acute Myocardial Infarction
Authors: Tomasz Mazurek, Robin Nijveldt, John S Yudkin, Alexander Hirsch, Yvo Smulders, Albert C van Rossum
Journal: Circulation (2008)

Extravascular expression of inflammatory mediators may adversely influence coronary lesion formation and plaque stability through outside-to-inside signaling. Accordingly, we examined peri-coronary...
Dendritic Cells Stimulate the Expansion of bcr-abl Specific CD8+ T Cells With Cytotoxic Activity Against Leukemic Cells From Patients With Chronic Myeloid Leukemia
Authors: Mie Nieda, Andrew Nicol, Akiko Kikuchi, Koichi Kashiwase, Kerry Taylor, Kenji Suzuki, Kenji Tadokoro, Takeo Juji
Journal: Blood (1998)
Abstract 8789: Elevated Serum Lipoprotein(a) Level as Predictor of Coronary Plaque Vulnerability in Men Using 64-Multidetector Computed Tomography
Authors: Hiroto Utsunomiya, Hideya Yamamoto, Eiji Kunita, Toshiharu Oka, Ryo Yamazato, Yoji Urabe, Ken Ishibashi, Takenori Okada, Kenji Nishioka, Tomoki Shokawa, Satoshi Kurisu, Yukiko Nakano, Takafumi Ishida, Yasuki Kihara
Journal: Circulation (2010)

Background: Lipoprotein(a) [Lp(a)] is characterized by its specific apolipoprotein(a). It has been implicated in the regulation of the expression of plasminogen activator inhibitor-1 and shown to attenuate plasminogen binding to platelets. Thus, Lp(a) may provide a link between the pathogenic process of thrombosis and atherosclerosis, and may be associated with the development of vulnerable plaque prone to rupture with subsequent pathogenesis of acute coronary syndrome (ACS). We investigated whether the elevated serum Lp(a) level is related to coronary plaque vulnerability. Methods: We enrolled 216 consecutive patients (age: 67 ± 11 years, 63% men) with suspected coronary artery disease referred for 64-multidetector computed tomography (CT). Serum Lp(a) was measured by an immunoturbidimetric assay within 1 week after CT angiography. Coronary arteries were assessed using a 17-segment model for the presence and extent of non-calcified plaque (NCP). Furthermore, vulnerable plaque (VP) was defined as if NCP h...
Abstract 16501: VEGF and VEGF-R1 Levels in Skeletal Muscle of PAD Patients: A Report From the AMNESTI (Angiogenesis and Mechanisms of Exercise Training in PAD) Clinical Trial
Authors: W S Jones, Natasha N Duggan, Brian D Duscha, Jennifer L Robbins, Ayotunde O Dokun, Judith G Regensteiner, William R Hiatt, Brian H Annex
Journal: Circulation (2011)

Background: A common manifestation of peripheral artery disease (PAD) is intermittent claudication (IC), and an effective treatment for IC is supervised exercise training (SET). The mechanism of im...
Pandemic influenza A(H1N1)v: Human to pig transmission in Norway?
Authors: M Hofshagen, B Gjerset, C Er, A Tarpai, E Brun, B Dannevig, T Bruheim, I G Fostad, B Iversen, O Hungnes, B Lium
Journal: Eurosurveillance (2009)

In Norway there is an ongoing outbreak in pigs of infections with pandemic influenza A(H1N1)v virus. The first herd was confirmed positive on 10 October 2009. As of 26 October, a total of 23 herds have been diagnosed as positive. The majority of the herds seem to have been infected by humans. Sequence analysis of pig viruses from the index farm shows that they are identical or virtually identical to human viruses from the same geographical region.
Factors associated with recovery from and relapse into major depressive disorder in the elderly
Authors: G A Hinrichsen, N A Hernandez
Journal: American Journal of Psychiatry (1993)

This research examined demographic, clinical, and family factors in elderly depressed patients in order to ascertain which ones were related to the patients' recovery from and relapse into major depression.One hundred twenty-seven elderly inpatients with a diagnosis of major depressive disorder according to the Research Diagnostic Criteria were evaluated at hospital admission and followed prospectively for 1 year. At the time of each patient's admission, the spouse or an adult child was also interviewed with measures that examined family-related issues. Recovery and relapse were determined according to explicit criteria from the Longitudinal Interval Follow-Up Evaluation.No demographic or clinical characteristics of the patients were predictors of recovery or relapse. Three family variables measured at the time of the patients' hospitalization were prospectively related to patients' status as not recovered at follow-up: the spouses' and adult children's psychiatric symptoms, their reported difficulties in caring for the depressed older patients, and their poorer physical health. However, relatives' reported difficulties with patient care were associated with reduced likelihood of relapse among the subgroup of patients who actually did recover.The findings are consistent with research in mixed-age samples that has documented the influence of interpersonal factors on the course of depression.
Initial Results Of a Phase II Trial Of Sorafenib Plus Standard Induction In Older Adults With Mutant FLT3 Acute Myeloid Leukemia (AML) (Alliance trial C11001)
Authors: Geoffrey L. Uy, Ben Sanford, Guido Marcucci, Weiqiang Zhao, Susan Geyer, Heidi D. Klepin, Bayard L. Powell, Maria R. Baer, Wendy Stock, Richard M. Stone, Richard A. Larson
Journal: Blood (2013)
Abstract 4990: Multi-Marker Approach Using Novel Biomarkers Improves Prediction of Subclinical Atherosclerosis: Observations from the Dallas Heart Study
Authors: Anand Rohatgi, Susan Matulevicius, Sandeep R Das, Amit Khera, Darren K McGuire, Colby R Ayers, James A de Lemos
Journal: Circulation (2008)

Background: Although many novel markers are independently associated with cardiovascular risk, few significantly improve predictive performance. We hypothesized that combining multiple novel biomarkers would improve prediction of subclinical atherosclerosis over standard methods. Methods: We measured coronary calcium (CAC) by electron beam CT (n=2440), as well as hsCRP, NT-proBNP, and four novel biomarkers including soluble receptor for advanced glycation end products (sRAGE), peptidoglycan recognition protein-1 (PGLYRP-1), soluble endothelial cell-selective adhesion molecule (sESAM), and osteoprotegerin (OPG) in the Dallas Heart Study, a multi-ethnic probability-based population sample age 30 – 65. An integer score was created based on the number of biomarkers that were elevated &gt;= 95th percentile for sex and race. The incremental value of the biomarker score over a model including Framingham risk categories in predicting CAC was analyzed. Results: Increasing biomarker score was associated with increased CAC prevalence (59% for score &gt;= 3 vs. 17% for score = 0, figure ). Compared with the Framingham risk model alone, the addition of the biomarker score significantly increased the C index (0.705 vs. 0.749, p&lt;0.0001), lowered the Bayesian Information Criterion (2232 vs. 2195), and also improved reclassification into higher and lower risk categories (Net Reclassification Index = 14.2%, p&lt;0.0001; Integrated Discrimination Index =2.4%, p&lt;0.0001). Conclusion: Use of a multi-marker score including established and novel biomarkers improves prediction of CAC beyond the Framingham risk categories using multiple different statistical metrics. Figure. Prevalence of CAC by Biomarker Score*