tbuckley/cabot-search huggingface dataset:
Progress of the Science of Nutrition in Japan.
Authors: 矩 佐伯
Journal: JAMA (1927)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Risk for subsequent venous thromboembolic complications in carriers of the prothrombin or the factor V gene mutation with a first episode of deep-vein thrombosis
Authors: Paolo Simioni, Paolo Prandoni, Anthonie W. A. Lensing, Davide Manfrin, Daniela Tormene, Sabrina Gavasso, Bruno Girolami, Corrado Sardella, Martin Prins, Antonio Girolami
Journal: Blood (2000)
Abstract 9791: Sex Disparities in Implantable Cardioverter Defibrillator (ICD) Outcomes: Findings From the Ontario ICD Database
Authors: Derek R MacFadden, Eugene Crystal, Andrew D Krahn, Iqwal Mangat, Jeffrey S Healey, Paul Dorian, Yaariv Khaykin, David Birnie, Christopher S Simpson, Arnold Pinter, Andrew J Calzavara, Jack V Tu, Douglas S Lee
Journal: Circulation (2011)

BACKGROUND: Sex disparities may exist in decisions to implant an ICD, complications and patient outcomes, but contributing factors are not fully elucidated. We determined if men and women who were referred or implanted with an ICD differed in their device use, complications, and outcomes. METHODS: We examined prospectively-enrolled patients referred for consideration of ICD implantation in Ontario between Feb 2007 to Jul 2010 in the Ontario ICD Database. Patients were followed for 45-day complications, and occurrence of ICD-delivered therapies (i.e., appropriate shock, appropriate therapy, and inappropriate therapy) and death within one-year follow-up. Multivariable-adjusted odds ratios (aOR) and hazard ratios (aHR) &gt; 1.0 signified increased likelihood of implantation, complications, ICD-delivered therapies, or death in women. RESULTS: Of 6021 patients (4733 men) referred for ICD implantation, 1155 women (89.7%) and 4294 men (90.7%) received devices, with an overall aOR of 0.87 (95%CI; 0.69-1.10, p=0.24). Women were significantly more likely than men to have a minor (aOR 1.55; 95%CI; 1.09-2.20, p=0.014), major (aOR 1.78, 95%CI; 1.24-2.58, p=0.002), or any complication (aOR 1.50, 95%CI; 1.12-2.00, p=0.006). Among 5213 persons (4108 men) contributing 3,860 person-years of follow-up, there was a lower likelihood of appropriate ICD-delivered therapies in women. Adjusted HRs were 0.69 (95%CI; 0.51-0.93, p=0.015) for appropriate shock, 0.73 (95%CI; 0.59-0.90, p=0.003) for appropriate ICD-delivered therapy, and 0.97 (95%CI; 0.64-1.55, p=0.885) for inappropriate shock ( Figure ). Mortality did not differ among male and female ICD recipients: aHR=1.00 (95%CI; 0.64-1.55, p=0.988). CONCLUSIONS: ICD implantation rates were similar in men and women after referral to an electrophysiologist. Female ICD recipients exhibited higher rates of early complications and were less likely to experience appropriate shocks or antitachycardia therapy than men.
An Open-Label, Phase II Study Of The JAK1 Inhibitor INCB039110 In Patients With Myelofibrosis
Authors: John Mascarenhas, Moshe Talpaz, Vikas Gupta, Michael Savona, Paul Coughlin, Elliott Winton, Deborah Hunter, Bijoyesh Mookerjee, Lance Leopold, Jason Clark, Peter O'Neill, Ccrp, Ronald Hoffman, Srdan Verstovsek
Journal: Blood (2013)
Pioglitazone Decreases Coronary Artery Inflammation in Impaired Glucose Tolerance and Diabetes Mellitus
Authors: Yoshikazu Nitta, Nobuhiro Tahara, Atsuko Tahara, Akihiro Honda, Norihiro Kodama, Minori Mizoguchi, Hayato Kaida, Masatoshi Ishibashi, Naofumi Hayabuchi, Hisao Ikeda, Sho-ichi Yamagishi, Tsutomu Imaizumi
Journal: JACC. Cardiovascular imaging (2013)
Age at onset and gender of schizophrenic patients in relation to neuroleptic resistance
Authors: Herbert Y. Meltzer, Jonathan Rabinowitz, Myung A. Lee, Philip A. Cola, Rakesh Ranjan, Robert L. Findling, Paul A. Thompson
Journal: American Journal of Psychiatry (1997)

The age at onset of schizophrenia for males has usually but not always been reported to be less than that for females. Early onset has also been associated with poor response to neuroleptic treatment and worse long-term outcome. The authors compared age at onset in neuroleptic-resistant and -responsive schizophrenic patients to determine whether the gender difference in age at onset is related to response to neuroleptic treatment.The subjects were 322 patients with schizophrenia or schizoaffective disorder who were consecutively admitted to a university hospital-based research program.Analysis of variance showed significant relationship between age at onset and both gender and longterm responsivity to neuroleptic drugs. The mean ages at onset in the neuroleptic-responsive men (mean = 21.2 years, SD = 6.1, N = 75), neuroleptic-resistant men (mean = 19.4 years, SD = 4.7, N = 119), and neuroleptic-resistant women (mean = 20.1 years, SD = 6.3, N = 77) were fairly similar, whereas that of the neuroleptic-responsive women (mean = 24.2 years, SD = 8.7, N = 51) was significantly greater than for all other groups. A simple effects model indicated that male and female neuroleptic-resistant patients did not differ significantly in mean age at onset, whereas male and female neuroleptic-responsive patients did. The effect of gender and neuroleptic responsivity on age at onset was related to schizophrenic subtype.These results confirm previous data indicating neuroleptic resistance is associated with early onset. The finding that the difference in age at onset between males and females is smaller in neuroleptic-resistant patients than in neuroleptic-responsive patients suggests that neuroleptic-resistant patients differ premorbidly as well as after onset of illness.
Abstract 217: Quality of CPR Performed on a Mattress Can Be Improved with a Novel CPR Feedback Device
Authors: Isabelle Banville, Lizabeth Rose, Patty O'Hearn, Timothy Campbell, Richard Nova, Fred Chapman
Journal: Circulation (2011)

Accelerometer-based CPR feedback devices estimate sensor movement, but cannot distinguish between compression of the chest and deflection of the underlying surface (e.g. mattress). This study aims to compare CPR quality improvement provided by feedback from an accelerometer-based device and a novel device. The novel device provides visual feedback on compression depth, based on measured changes in magnetic field strength between a backpad and a chestpad, and gives audible and visual rate guidance. Methods: Critical care nurses performed 2 sets of continuous chest compressions on a weighted manikin placed on a backboard on a common foam mattress and hospital bed. For “baseline”, participants did 120s of CPR with no training or feedback. After 10 minutes for rest and training on use of device feedback to do Guidelines 2010 CPR, they did 120s of compressions with feedback from the novel (MAG) or the accelerometer-based (ACC) device, as randomized. Manikin data on chest compressions were captured and analyzed (PC Skillreporting System, Laerdal). Results: Weight and height (73 ± 1 kg, 164 ± 6 cm, mean ± SD) of the 22 nurses (1 male) did not differ significantly between groups. For all nurses, baseline chest compression depth was 37.3 ± 9 mm and rate was 101 ± 17 min -1 . Manikin-recorded compression depth was significantly higher in the MAG (n=11, 49.0 ± 9 mm) than the ACC group (n=11, 39.3 ± 7 mm), p=0.009. The ACC device-estimated depth (52.9 ± 8 mm) guided the feedback resulting in actual depth of 39.3 ± 7 mm. Compared to baseline, the depth was significantly higher with MAG (95% CI: [2.5, 17.3]) but not with ACC feedback (95% CI: [-3.9, 11.3]). There was a difference in compression rate (94 ± 9 vs 107 ± 10 min -1 , p=0.005), but not duty cycle (42 ± 4 vs 44 ± 4 %, p=0.3) for MAG vs ACC. Conclusion: In a realistic simulation on a hospital bed, use of a novel CPR feedback technology (MAG) by nurses significantly improved their chest compression depth compared to no feedback or to accelerometer-based feedback.
Synergism of combined lithium-neuroleptic therapy: a double-blind, placebo-controlled case study
Authors: Bigelow Lb, Weinberger Dr, Wyatt Rj
Journal: American Journal of Psychiatry (1981)

The authors describe a longitudinal, placebo-controlled study of the response to drug treatment of a 62-year-old schizoaffective patient hospitalized for 40 years. While neither lithium nor a neuroleptic drug alone was effective, both drugs administered simultaneously led to the gradual extinction of a pronounced behavioral cycle and the disappearance of manifest psychosis. The authors suggest a synergistic interaction between the two drugs and stress the need for sustained trials of the combination in patients with similar behavioral cycles.
Patients were not representative of all patients with the syndrome
Authors: R. Gibbons, A. Macintyre, C. Richards
Journal: BMJ (1996)

Cognitive behaviour therapy for the chronic fatigue syndrome Evening primrose oil and magnesium have been shown to be effective EDITOR,-In their paper on cognitive behaviour therapy for -the chronic fatigue syndrome Michael Sharpe and colleagues state that many pharmacological treatments have been suggested but none are of proved value.'Last year Lewith stated that the only two treatments that had been properly evaluated were evening primrose oil and magnesium by injection.2Intramuscular magnesium supplements have been given to patients with low red cell magnesium in a double blind placebo controlled trial; myalgia and fatigue improved in about 70% of subjects.3Evening primrose oil has been used to treat myalgic encephalomyelitis and is the only other treat- ment that has been adequately tested in a controlled trial.High doses in randomised controlled trials have been shown to have a significant effect in 70-80% of patients with myalgic encephalomyelitis or the chronic fatigue syndrome.4I would be interested to hear Sharpe and colleagues' comments about these papers.
Abstract 9844: Clinical Outcomes of Saphenous Vein Graft Interventions Using Drug Eluting Stents Compared with Bare Metal Stents: A Comprehensive Meta-Analysis of All Randomized Clinical Trials
Authors: Mahboob Alam, Salman J Bandeali, Saima A Shahzad, Salim S Virani, Hani M Jneid, K B Ramanathan, Neal S Kleiman, Nasser M Lakkis
Journal: Circulation (2011)

Introduction: Clinical outcomes of PCI in patients with saphenous vein grafts (SVG) remain poor despite the use of drug eluting stents. There is disparity in clinical outcomes in SVG PCI based on various registries while randomized data remains scant. Hypothesis: In the setting of an earlier randomized trial showing higher mortality in patients who underwent DES implantation for SVG disease we sought to assess whether DES use in SVG interventions will improve short and intermediate-term clinical outcomes compared to BMS. Methods: An aggregate data meta-analysis of clinical outcomes in RCTs comparing PCI with DES vs. BMS for SVGs reporting at least 12 months of follow-up was performed. A search of Medline and conference proceedings between 01/2003 and 05/2011 identified 4 RCTs enrolling 812 patients (416 in DES and 396 in BMS arms). Summary odds ratios &amp; 95% confidence intervals were calculated using the random-effects model. Review Manager Version 5.1 (The Cochrane Collaboration) was used for data analyses. Primary endpoint was all cause mortality. Secondary outcomes included non-fatal myocardial infarction (MI), repeat revascularization (i.e. target vessel revascularization [TVR] or target lesion revascularization [TLR]), and MACE (composite endpoint of death, MI and TLR/TVR). These outcomes were assessed in cumulative fashion at 30 days, 18 months and 36 months. Results: Overall, there were no inter-group differences in baseline clinical and socio-demographic characteristics. Following a median follow-up of 25 months (range 12 - 35months), patients in the DES and BMS group had similar rates of death, MI and MACE. Patients in the DES arm had significantly lower rates of repeat revascularization OR = 0.40, 95% CI 0.22 - 0.75). Table I provides details of the meta-analysis outcomes at various follow-up periods. Conclusions: Use of DES in SVG interventions is associated with significant reduction in rate of repeat revascularization without an excess in mortality.
Allogeneic Transplant Outcomes in Imatinib-Refractory Chronic Myeloid Leukaemia (CML) Are Similar to Transplant Outcomes in Imatinib-Responsive/Imatinib-Naïve CML and Appear To Be Predicted by the EBMT Risk Score.
Authors: Steven Stylian, Eileen T. Fennelly, Jason P. Butler, James P. Morton, Robyn Western, Cheryl J. Hutchins, Geoff R. Hill, Simon T. Durrant, Glen A. Kennedy
Journal: Blood (2006)
Abstract 10366: Quantitative Assessment of Artifacts on Cardiac Magnetic Resonance Imaging of Patients with Pacemakers and Implantable Defibrillators
Authors: Takeshi Sasaki, Rozann Hansford, Menekhem M Zviman, Ronald D Berger, Hugh Calkins, David A Bluemke, Henry R Halperin, Saman Nazarian
Journal: Circulation (2010)
Teaching patients with bipolar disorder to identify early symptoms of relapse
Authors: C. Cates, R. Morriss, N. Tarrier
Journal: BMJ (1999)

Surgical techniques should be fully evaluatedEditor-The editorial by Nicholson and Bradley on renal transplantation from living donors rightly pointed out that the United Kingdom has a lower rate of transplantations which use kidneys from living donors than the United States or Norway. 1 The recent report by the Royal College of Surgeons on organ transplantation in the United Kingdom recommended that steps should be taken to increase the use of kidneys from living donors in the United Kingdom to offset the shortage of cadaveric kidneys as well as to improve outcome. 2 In the United Kingdom in 1998, 38% more transplantations were performed using organs from living donors than in 1997.However, there is still some way to go if a level similar to that of the United States or Scandinavia (25-30%) is to be achieved.Nicholson and Bradley identify the risks associated with donor nephrectomy and state that much of the morbidity that occurs after open nephrectomy is related to the wound.For this reason they believe that the use of laparoscopically assisted donor nephrectomy needs to be examined in the light of the experience of, for example, the Johns Hopkins Hospital in Baltimore, Maryland.However, there have been no randomised prospective trials of this procedure, which takes longer than open nephrectomy.Furthermore, all of the non-randomised comparisons have been of open nephrectomy performed through a loin incision, with or without removal of a rib.If an anterior
Good care at the end of life, not hastening death
Authors: Lulu Kreeger
Journal: BMJ (2008)

Treloar misunderstands the fundamental premise of the Liverpool care pathway (LCP).1 A patient is put on the pathway only once it is recognised they are dying imminently, within hours to a few days.2 The evidence does not support that artificial hydration or nutrition has a role to ease symptoms and suffering and may, in fact, add to it.3 

Deep …
Abstract 3506: Electrophysiological Features of Atrial Tachyarrhythmia after Left Atrial Roof Line during Catheter Ablation of Atrial Fibrillation
Authors: Toshiya Kurotobi, Hiroshi Ito, Katsuomi Iwakura, Shigeo Kawano, Atsunori Okamura, Yasushi Koyama, Motoo Date, Koichi Inoue, Kenshi Fujii
Journal: Circulation (2006)

Backgrounds; Several reports have suggested that the atrial tachyarrhythmia (AT) after catheter ablation for atrial fibrillation (AF) is generally caused by focally driven reentrant arrhythmia arou...
Brief Communication: Minute Chromatin Bodies in a Murine In Vitro Cell Line2
Authors: Sonia B. de Salum, Irene Larripa
Journal: JNCI Journal of the National Cancer Institute (1975)

A murine anaplastic sarcoma and an in vitro cell line established from it were studied by the TG banding technique. The neoplasm originated in a BALB/c mouse inoculated with human tumor cells. Microchromatin bodies were found in 100% of the karyotypes in the original tumor and in the 120 in vitro passages. A long marker chromosome, also observed in all metaphases, was interpreted as a translocation in tandem of a No. 16 chromosome into a No. 1; this involved loss of the centromeric part of chromosome No. 1.
Clopidogrel 600-Mg Double Loading Dose Achieves Stronger Platelet Inhibition Than Conventional Regimens
Authors: Philippe L. L’Allier, Grégory Ducrocq, Nicolas Pranno, Stéphane Noble, Reda Ibrahim, Jean C. Grégoire, Fabian Azzari, Anna Nozza, Colin Berry, Serge Doucet, Benoit Labarthe, Pierre Théroux, Jean-Claude Tardif
Journal: Journal of the American College of Cardiology (2008)
Erratum to: Fluid challenges in intensive care: the FENICE study
Authors: Maurizio Cecconi, Christoph Hofer, Jean-Louis Teboul, Ville Pettila, Erika Wilkman, Zsolt Molnar, Giorgio Della Rocca, Cesar Aldecoa, Antonio Artigas, Sameer Jog, Michael Sander, Claudia Spies, Jean-Yves Lefrant, Daniel De Backer
Journal: Intensive Care Medicine (2015)
Intraoperative Radiation Therapy (IORT) for Cerebral Glioblastoma
Authors: Masao Matsutani, Osamu Nakamura
Journal: Neuro-Oncology (1991)

In the review of the phase III studies for malignant gliomas, it was demonstrated that radiation therapy with a conventional dose resulted in the poor local control of tumors. A high dose external irradiation with 70Gy succeeded to prolong a median survival as compared to a conventional dose with 50–60Gy, and it suggested that higher irradiation dose could sterilize the remaining malignant and radioresistant remnants after surgery and external radiation therapy.
Sept9_v4 Regulates Cdc42 activation and promotes directional protrusion
Authors: Alexander D. Chacko, Naomi L. Pentland, Simon S. McDade, Hilary Russell, Peter A. Hall
Journal: Cancer Research (2006)

1809   The activity of Rho-GTPases is required for the cytoskeletal remodelling associated with directed cell migration. Disruption of Rho-GTPases and their associated effector proteins leads to polarity defects, underlining the fact that in order for efficient cell migration to occur, it is necessary for the Rho-GTPases to be activated in a temporally and spatially controlled manner. Previously, we showed that the Sept9_v4 splice isoform mRNA was significantly increased in metastatic carcinoma samples compared to benign tissue, and that epithelial cell lines over expressing the Sept9_v4 protein displayed increased motility in different assays. Here we show that expression of Sept9_v4 in epithelia leads to the rapid appearance of polarised lamellapodia and of activated Cdc42-GTP at the migrating cell front. Furthermore, Sept9_v4 co-precipitates with the inactive, GDP-bound Cdc42 and this interaction is lost concomitantly with the early Cdc42 activation. The correct localization of Cdc42-GTP at the migrating cell front, hydrolysis of Cdc42-GTP back to Cdc42-GDP, and release of Cdc42-GTP from Sept9 upon activation, are all lost upon expression of the GTPase domain mutant Sept9_v4 G144V, suggesting that the septin GTPase domain has a role in cell migration and polarity. Although expression of the truncated Sept9_v4 splice variant hastens Cdc42 activation and directional protrusion, SiRNA experiments show Sept9 is dispensable for these processes. Our data provide evidence for the proposed role of septins as a scaffold controlling localisation of signalling proteins involved in polarity and cytoskeletal remodelling, and strengthen the link between septins and neoplasia.
Abstract 3273: Timely Access to Care - Risk Stratification Utilizing the Seattle Heart Failure Model in patients with Advanced Heart Failure: Dying to be seen.
Authors: Filio Billia, Vaska Micevski, Susan Carson, Diego H Delgado, Heather J Ross
Journal: Circulation (2007)

Introduction Heart failure is an epidemic with age-adjusted mortality of 45%/5 years. Multidisciplinary heart function clinics (HFC) have been shown to improve outcomes in patients. Timely access to cardiac care remains one of Canada’s leading concerns. Risk stratification of patients upon referral to a HFC may identify patients that require urgent access to, and benefit from, multidisciplinary care. Hypothesis To determine if a priori assessment using the Seattle Heart Failure Survival Model (SHFM) at the time of referral to a multidisciplinary HFC would help risk stratify patients regarding urgency of consultation. Methods The referral packages of patients known to have died prior to or within 60 days of initial consultation were retrospectively reviewed (Group 1). Data were collected to determine the mortality risk based on the SHFM. Age and sex-matched controls were randomly selected from our HFC database (Group 2). Statistical analysis was performed using SPSS. Results A total of 107 patients were included in this study (Group 1, n=57; Group 2 n=50). There were no significant differences in baseline characteristics between the groups. In Group 1, 38% of patients died before being evaluated, while the remaining 62% died within 60 days of the initial HFC visit. The majority of patients in both groups had either ischemic or idiopathic dilated cardiomyopathy (52% and 22%, respectively). Patients in Group 1 reported NYHA class III/IV symptoms 40%/33%, respectively, versus Group 2 patients reporting NYHA class III/IV symptoms 46%/8%, respectively. There was a statistically significant difference in the mean SHFM mortality risk score, predicted at the time of initial receipt of referral, between the study groups with Group 1 patients having a much higher predicted mortality versus Group 2 at 1, 2 and 5 years (p&lt;0.001). Conclusion The SHFM is a useful tool to risk stratify patients with HF at the time of referral/entry into a multidisciplinary clinic. It provides a reliable method to triage risk and ensure that those at greatest risk are seen soonest, hence facilitating timely access for care. Prospective validation regarding the triage applicability of the SHFSS is needed.
Precision Medicine in Patients With Resistant Hypertension and Obstructive Sleep Apnea
Authors: Manuel Sánchez-de-la-Torre, Abdelnaby Khalyfa, Alicia Sánchez-de-la-Torre, Montserrat Martinez-Alonso, Miguel Ángel Martinez-García, Antonia Barceló, Patricia Lloberes, Francisco Campos-Rodriguez, Francisco Capote, Maria José Diaz-de-Atauri, Maria Somoza, Mónica González, Juan-Fernando Masa, David Gozal, Ferran Barbé
Journal: Journal of the American College of Cardiology (2015)