tbuckley/cabot-search huggingface dataset:
Sickle liver disease—An unusual presentation in a compound heterozygote for HbS and a novel β‐thalassemia mutation
Authors: Timothy J.S. Cross, Philip A. Berry, Nuzhat Akbar, Julia Wendon, S.L. Thein, Phillip M. Harrison
Journal: American Journal of Hematology (2007)

A 38-year-old Ghanaian man presented with a 6-month history of worsening pruritus, jaundice, and ascites. He was previously fit and well and rarely drank alcohol. Screening tests for chronic liver disease including viral, autoimmune, and other metabolic causes including iron overload were unremarkable. A liver biopsy performed at the referring hospital demonstrated intralobular cholestasis and cirrhosis. He was listed for liver transplantation but subsequently developed sepsis with multiple organ failure and died. The sickle solubility test was positive. Blood smear showed cells consistent with liver failure and no sickle cells. Hemoglobin electrophoresis revealed HbA2 2.8%, HbF 0.5%, and HbS greater than HbA (49.6% vs. 41.3%) in the absence of blood transfusion. Sequence analysis of the beta-globin genes showed he was a compound heterozygote for the Hbs mutation at codon 6 (CAG --> GTG) and a novel mutation at position 844 of intron 2 (betaIVS2-844 C --> A). A diagnosis of sickle hepatopathy causing decompensated cirrhosis was made. This case is unusual insomuch as this patient was asymptomatic for over 35 years and represents a novel presentation of sickle cell disease. Sickle cell disease should be considered in appropriate patients when unusual presentations of liver disease arise.
The Osseous System: A Handbook of Roentgen Diagnosis
Authors: D. R. Germann
Journal: JAMA (1964)

This handbook, written by one of the most highly respected professors of radiology in the country, reflects many years of practical experience. There are numerous drawings and graphic x-ray reproductions with well-marked details. As the author states, this book, directed at the "occasional radiographer," should be used as the starting point for the roentgenographic examination of the bony structure. However, it would also serve as a good reference for the hospital house staff who find themselves on occasion faced with bone problems. Several technical points are made, but not belabored, since such information is readily available in other texts. While the present volume could be criticized as either too superficial or too technical, depending on the point of view, for the occasional radiographer it would seem to be well organized, and to present fundamentals. Many references to more specific texts and articles are given. The section on trauma, although well
Measuring Patient Adherence
Authors: Barbara J. Turner, Frederick M. Hecht
Journal: Annals of Internal Medicine (2002)

Letters2 July 2002Measuring Patient AdherenceBarbara J. Turner, MD and Frederick M. Hecht, MDBarbara J. Turner, MDUniversity of Pennsylvania, Philadelphia, PA 19104 (Turner)San Francisco General Hospital, San Francisco, CA 94410 (Hecht)Search for more papers by this author and Frederick M. Hecht, MDUniversity of Pennsylvania, Philadelphia, PA 19104 (Turner)San Francisco General Hospital, San Francisco, CA 94410 (Hecht)Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-137-1-200207020-00025 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail IN RESPONSE:We appreciate the thoughtful comments of Dr. Liu and his coauthors. We understand that the authors feel that their adherence score reflects a composite of several approaches to measure adherence. However, the authors first used electronic monitor data and then filled in missing data points with pill count and, finally, interview data. Our editorial aimed to help the reader understand that electronic monitor data served as the centerpiece of this approach. If a researcher had nearly complete adherence data on his or her study participants from electronic monitors, Liu and colleagues' approach would require minimal additional data from ...References1. Bangsberg DR, Hecht FM, Charlebois ED, Zolopa AR, Holodniy M, Sheiner L, et al . Adherence to protease inhibitors, HIV-1 viral load, and development of drug resistance in an indigent population. AIDS. 2000;14:357-66. [PMID: 10770537] CrossrefMedlineGoogle Scholar2. Vitolins MZ, Rand CS, Rapp SR, Ribisl PM, Sevick MA. Measuring adherence to behavioral and medical interventions. Control Clin Trials. 2000;21 5 Suppl 188S-94S. [PMID: 11018574] CrossrefMedlineGoogle Scholar Author, Article, and Disclosure InformationAuthors: Barbara J. Turner, MD; Frederick M. Hecht, MDAffiliations: University of Pennsylvania, Philadelphia, PA 19104 (Turner)San Francisco General Hospital, San Francisco, CA 94410 (Hecht) PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoA Comparison Study of Multiple Measures of Adherence to HIV Protease Inhibitors Honghu Liu , Carol E. Golin , Loren G. Miller , Ron D. Hays , C. Keith Beck , Sam Sanandaji , Judith Christian , Tomasa Maldonado , Dena Duran , Andrew H. Kaplan , and Neil S. Wenger Improving on a Coin Toss To Predict Patient Adherence to Medications Barbara J. Turner and Frederick M. Hecht Measuring Patient Adherence Honghu Liu , Andrew Kaplan , and Neil Wenger Metrics Cited byDeveloping a System to Assess the Quality of Cancer Care: ASCO's National Initiative on Cancer Care Quality 2 July 2002Volume 137, Issue 1Page: 72-73KeywordsAntiretroviral therapyViral load ePublished: 2 July 2002 Issue Published: 2 July 2002 Copyright & PermissionsCopyright © 2002 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Unusual acantholytic bullous dermatosis associated with neoplasia and IgG and IgA antibodies against bovine desmocollins I and II
Authors: Tadeusz P. Chorzelski, Takashi Hashimoto, Takeji Nishikawa, Tamotsu Ebihara, Marian Dmochowski, Mohamed Ismail, Stefania Jablońska
Journal: Journal of the American Academy of Dermatology (1994)
Lag Time to Benefit for Preventive Therapies
Authors: R. Scott Braithwaite
Journal: JAMA (2014)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
POSTGRADUATE STUDY IN EUROPE
Authors: Herman F. Strongin
Journal: JAMA (1926)

<h3>To the Editor:</h3> —The difficulty that I experienced recently before going abroad in obtaining information regarding certain aspects of postgraduate work in Europe makes me think that a few words may help avoid wasteful lessons. Regarding actual traveling aspects, one's financial ability is the guiding factor and controlling influence. What is the best time for getting an opportunity to work? There is a particular seasonal advantage, no matter what the study or specialty may be. That period covers the time when most of the university professors are teaching—from September to July. During July and August, because of the vacation season, the curricular schedule is irregular, and much time is lost waiting for courses to begin. The work that I was particularly interested in was gynecology and obstetrics, and the following applies to these specialties. Registration with the American Medical Association of Vienna is more or less advantageous. The best guide
The Communities of Scientists and Journal Peer Review
Authors: Elizabeth Knoll
Journal: JAMA (1990)

IN RECENT years, scientists and editors of scientific journals have often noted how few hard data exist on  workings of editorial peer review. Although pressures from inside and out increasingly encourage journals to be more explicit about their practices and more inclined to question their own habits, there is still a good deal of truth in  sardonic observation made 5 years ago that the arbiters of rigor, quality, and innovativeness in publishing scientific work do not apply to their own work  standards they apply in judging  work of others. 1 This paradox inspired The First International Congress on Peer Review in Biomedical Publication, with its goal of encouraging  systematic and empirical study of journals.  Of course, data and rigorous methods are not enough to make a science. The systematic study of peer review is even more deficient in theory than it is in data. Some
Outbreake of Marburg virus disease in Johannesburg.
Authors: J S Gear, G A Cassel, A J Gear, B Trappler, L Clausen, A M Meyers, M C Kew, T H Bothwell, R Sher, G B Miller, J Schneider, H J Koornhof, E D Gomperts, M Isaacson, J H Gear
Journal: BMJ (1975)

The first recognised outbreak of Marburg virus disease in Africa, and the first since the original epidemic in West Germany and Yugoslavia in 1967, occurred in South Africa in February 1975. The primary case was in a young Australian man , who was admitted to the Johannesburg Hospital after having toured Rhodesia. Two secondary cases occurred, one being in the first patient's travelling companion, and the other in a nurse. Features of the illness included high fever, myalgia, vomiting and diarrhoea, hepatitis, a characteristic maculopapular rash, leucopenia, thrombocytopenia, and a bleeding tendency. The first patient died on the seventh day from haemorrhage resulting from a combination of disseminated intravascular coagulation and hepatic failure. The other two patients were given vigorous supportive treatment and prophylactic heparin and recovered after an acute phase lasting about seven days. During this period on developed pancreatitis, the serum amylase remaining raised until the 32nd day after the onset of the illness. The other developed unilateral uveitis after having been asymptomatic for two months. This persisted for several weeks and Marburg virus was cultured from the anterior chamber of the eye.
Cyclosporine-Induced Hyperuricemia and Gout
Authors: Hsiao-Yi Lin, Leslie L. Rocher, Mark A. McQuillan, Stephan Schmaltz, Thomas D. Palella, Irving H. Fox
Journal: New England Journal of Medicine (1989)

To evaluate the frequency and the pathogenesis of hyperuricemia and gout during cyclosporine therapy, we studied renal-transplant recipients who were treated with either cyclosporine and prednisone (n = 129) or azathioprine and prednisone (n = 168). Among the patients with stable allograft function and serum creatinine concentrations below 265 μmol per liter, hyperuricemia was more common in the cyclosporine group than in the azathioprine group (84 percent vs. 30 percent; P = 0.0001). Gout developed in nine patients (7 percent) in the cyclosporine group, but no episodes occurred in the azathioprine group. Serum urate levels became elevated in 90 percent of the patients in the cyclosporine group who were treated with diuretics, as compared with 60 percent of those not treated with diuretics (P = 0.001); in the azathioprine group, the corresponding values were 47 percent and 15 percent (P = 0.0001). Serum urate levels did not correlate with trough blood cyclosporine levels in a selected subgroup (n = 40) of patients from the cyclosporine group, who were studied from 4 to 96 weeks after transplantation. Detailed studies of urate metabolism in six cyclosporine-treated patients revealed normal turnover rates for urate and decreases in creatinine and urate clearance, as compared with seven control subjects. We conclude that hyperuricemia is a common complication of cyclosporine therapy and is caused by decreased renal urate clearance. Gouty arthritis is the cause of considerable morbidity among renal-transplant recipients who receive cyclosporine. (N Engl J Med 1989; 321:287–92.)
National survey of current arrangements for diversion from custody in England and Wales.
Authors: S. Blumenthal, S. Wessely
Journal: BMJ (1992)

OBJECTIVES--To assess the extent and nature of psychiatric assessment schemes based at magistrates9 courts in England and Wales for the early diversion of mentally disordered offenders from custody and to determine the response of the NHS to new initiatives concerning alternatives to custody for this group. DESIGN--Postal survey of the probation service, petty sessional divisions, mental health provider units, and district purchasing authorities in England and Wales. SUBJECTS--All chief probation officers (n = 55), clerks to the justices (n = 284), managers of mental health provider units (n = 190), and purchasers of mental health services (n = 190) in each of the district health authorities. MAIN OUTCOME MEASURES--Number of psychiatric assessment schemes, practical difficulties in their operation, extent of regular liaison with health and social services; current and future intentions to purchase or provide services for diversion from custody. RESULTS--Data were obtained from every magistrates9 court. Forty eight psychiatric assessment schemes were identified with another 34 under development. Particular problems were lack of adequate transport arrangements, difficulties with hospital admissions, and overdependence on key people. There was little liaison between health, social services, and members of the criminal justice system. Twenty five of the 106 purchasers who responded had a policy dealing with diversion, and 39 had a scheme under development; 56 purchasers had no current or future plans about diversion. Sixty nine of the 150 providers who responded reported that diversion was included in their current or next business plan. CONCLUSION--Schemes to divert mentally disordered offenders from the criminal justice system are often hampered by lack of adequate transport arrangements, difficulties in hospital admissions, and overdependence on key people.
Dipeptidylpeptidase IV (CD26) defines leukemic stem cells (LSC) in chronic myeloid leukemia
Authors: Harald Herrmann, Irina Sadovnik, Sabine Cerny-Reiterer, Thomas Rülicke, Gabriele Stefanzl, Michael Willmann, Gregor Hoermann, Martin Bilban, Katharina Blatt, Susanne Herndlhofer, Matthias Mayerhofer, Berthold Streubel, Wolfgang R. Sperr, Tessa L. Holyoake, Christine Mannhalter, Peter Valent
Journal: Blood (2014)
Nondetection of Sentinel Lymph Node with Lymphoscintigraphy as a Result of Massive Malignant Invasion Shown by Positron Emission Tomography
Authors: Didier Blocklet, Vincent Donckier, Pierre Vereecken, Jean van Geertruyden, Marianne Laporte, Serge Goldman
Journal: Clinical Nuclear Medicine (2001)

The authors report the complementary roles of lymphoscintigraphy in sentinel node mapping and F-18 fluorodeoxyglucose (FDG) positron emission tomography (PET) in a massively invaded sentinel node.A 49-year-old woman was referred to the authors' institution after the resection of a malignant melanoma (Clark IV, Breslow 5.25) of the right buttock. No evidence of regional or distant organ metastases was observed on bone scintigraphy or thoracoabdominal or cerebral computed tomographs. Preoperative lymphoscintigraphy showed drainage around a circular structure, without any node detected. F-18 FDG PET imaging detected an area of focal, markedly hypermetabolic activity at the same location.The focal, markedly hypermetabolic activity detected by F-18 FDG PET corresponded to a massively invaded sentinel node not shown by lymphoscintigraphy but found and removed at the time of surgery. Radical regional lymphadenectomy showed only one small additional lymph node micrometastasis detected after immunohistochemical staining for S-100 protein and HMB45 antigen.This case emphasizes the complementary roles of lymphoscintigraphy sentinel node mapping and F-18 FDG PET. Indeed, a massively invaded sentinel node may be detected by PET but missed by lymphoscintigraphy.
The Pine River Statement: Human Health Consequences of DDT Use
Authors: Brenda Eskenazi, Jonathan Chevrier, Lisa Goldman Rosas, Henry A. Anderson, Maria S. Bornman, Henk Bouwman, Aimin Chen, Barbara A. Cohn, Christiaan de Jager, Diane S. Henshel, Felicia Leipzig, John S. Leipzig, Edward C. Lorenz, Suzanne M. Snedeker, Darwin Stapleton
Journal: Environmental Health Perspectives (2009)

Dichlorodiphenyltrichloroethane (DDT) was used worldwide until the 1970s, when concerns about its toxic effects, its environmental persistence, and its concentration in the food supply led to use restrictions and prohibitions. In 2001, more than 100 countries signed the Stockholm Convention on Persistent Organic Pollutants (POPs), committing to eliminate the use of 12 POPs of greatest concern. However, DDT use was allowed for disease vector control. In 2006, the World Health Organization and the U.S. Agency for International Development endorsed indoor DDT spraying to control malaria. To better inform current policy, we reviewed epidemiologic studies published from 2003 to 2008 that investigated the human health consequences of DDT and/or DDE (dichlorodiphenyldichloroethylene) exposure.We conducted a PubMed search in October 2008 and retrieved 494 studies.Use restrictions have been successful in lowering human exposure to DDT, but blood concentrations of DDT and DDE are high in countries where DDT is currently being used or was more recently restricted. The recent literature shows a growing body of evidence that exposure to DDT and its breakdown product DDE may be associated with adverse health outcomes such as breast cancer, diabetes, decreased semen quality, spontaneous abortion, and impaired neurodevelopment in children.Although we provide evidence to suggest that DDT and DDE may pose a risk to human health, we also highlight the lack of knowledge about human exposure and health effects in communities where DDT is currently being sprayed for malaria control. We recommend research to address this gap and to develop safe and effective alternatives to DDT.
A CYSTOSCOPE HOLDER
Authors: Charles A. Hill
Journal: JAMA (1923)

Cystoscopy in the female, especially when the irrigation of the kidneys, the dilation of ureteral constrictions, injections in pyelography, or the study of urine specimens is undertaken, necessitates a technic that requires the services of a trained assistant or nurse, and this fact limits the use of the cystoscope to one who is surrounded by such assistants. There can be no doubt that many an enthusiast in this work is forced to disregard his desires, owing to the fact that cystoscopy and treatment of the female kidney and ureteral tract cannot be properly and successfully carried out without competent assistance. With the technic that I employ, and with a trained assistant nurse, it is often found necessary for the assistant to hold the cystoscope under such conditions as during the changing of catheters, in irrigations, in pyelography when the cystoscope is not removed that the catheter may be reintroduced to
Changes in consumption (VO2), delivery (DO2) and extraction (O2 ext) of oxygen during orthotopic liver transplantation (OLT)
Authors: J. Moreno, F. Acosta, J.S. Ortega, A.R. Ribó, A. Olivaras, R.F. Contreras, P. Parrilla, F.S. Bueno, P. Ramires, R. Robles
Journal: Journal of Hepatology (1991)
MARKEDLY INCREASED CIRCULATING RHO-KINASE ACTIVITY IN PATIENTS WITH CHRONIC HEART FAILURE
Authors: Luigi Gabrielli, Jorge Jalil, Maria P. Ocaranza, Ivan Godoy, Paul McNab, Pablo Castro, Ulises Novoa, Italo Mora, Sergio Lavandero, Lorena Garcia, Ivonne Padilla
Journal: Journal of the American College of Cardiology (2010)
Brill's Disease
Authors: Herbert R. Morgan, Franklin A. Neva, Robert J. Fahey, Maxwell Finland
Journal: New England Journal of Medicine (1948)

THE name Brill's disease is usually given to the isolated cases of typhus fever that occur in the coastal towns of the northeastern United States.1 In 1934 Zinsser2 showed that these cases develop almost exclusively in immigrants from areas where there have been epidemics of louse-borne typhus fever. He demonstrated that the rickettsias that he was able to isolate from a few of these patients resembled the causative agent of epidemic or louse-borne typhus fever but that the disease was not associated with louse infestation. He came to the conclusion that Brill's disease represented a recrudescence of a latent infection . . .
Organ transplant recipients may die when insurance for immunosuppressants runs out
Authors: Fred Charatan
Journal: BMJ (2007)

Young transplant recipients who lose their insurance coverage are more likely to stop taking essential anti-rejection drugs, which can increase their risk of organ loss and death, a new study shows ( Pediatric Transplantation 2007;11:127-31 doi: 10.1111/j.1399-3046.2006.00639.x).

“Kids with transplanted kidneys who lose their insurance have a nine times greater chance of dying than those who don't,” said leading author Mark Schnitzler, associate professor in …
A PRELIMINARY NOTE ON THE TREATMENT OF INFECTED HAEMOTHORAX
Authors: J. F. Dobson
Journal: BMJ (1918)

TREATMENT OF INFECTED HAEMOTHORAX, [FEB.2, I918 clot removed.Pleural cavity swabbed clean.Diaphragm sutuLred with catgut.Laceration of outer and lower border of liver admitting three fingers, but liver not bleeding.Peritoneal cavity s\vabbed dry, peritoneum closed.Right kidney split across beyond repair.Nephrectomy.Incision closed except for small two-way catheter left in para-renal space for fortyeiglht hours.The operationi was carried out entirely under local aniaesthesia-no gas and oxygeni.An almost continuous conversationi was carried oIn between the patienlt and the anaes- thetist during the whole operation.Progress.-Onaccount of ditficulty in finiding another donor of his blood group, sodium bicarbonate was given intravencusly at the en(d of the operation.Recovery was complete and unieventful.The lung vas in almost complete expansion in less than forty-eiglht hours.Although the patient remainied perfectly well and had never complained sinice operation, on the twenty- first day ani increasing area of dullness was noted in right chest.Oni explorationi, fluid was founld and 48 oz. of thini serum, of tlle colotir anid consistency of olive oil, wvas wvithdrawni by aspiratioil.Cultures, staphylococci.Explored tenl days later-no luiidi fouLnd.He was evacuated oni
RICHARD EXD: HIS CONTRIBUTION TO SCABIES.*
Authors: REUBEN FRIEDMAN
Journal: British Journal of Dermatology (1937)

Journal Article RICHARD EXD: HIS CONTRIBUTION TO SCABIES. Get access REUBEN FRIEDMAN, M.D. REUBEN FRIEDMAN, M.D. Associate in Dermatology and Syphilology, Temple University School of Medicine. Philadelphia Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology and Syphilis, Volume 49, Issue 12, 1 December 1937, Pages 527–545, https://doi.org/10.1111/j.1365-2133.1937.tb10385.x Published: 01 December 1937