FK506-Induced Autoimmune Diabetes
Authors: Toshihide Kawai, Akira Shimada, Akira Kasuga
Journal: Annals of Internal Medicine (2000)

Letters21 March 2000FK506-Induced Autoimmune DiabetesToshihide Kawai, MD, Akira Shimada, MD, and Akira Kasuga, MDToshihide Kawai, MDKeio University School of Medicine; Tokyo, Japan 160-8582 (Kawai)Keio University School of Medicine; Tokyo, Japan 160-8582 (Shimada)Keio University School of Medicine; Tokyo, Japan 160-8582 (Kasuga)Search for more papers by this author, Akira Shimada, MDKeio University School of Medicine; Tokyo, Japan 160-8582 (Kawai)Keio University School of Medicine; Tokyo, Japan 160-8582 (Shimada)Keio University School of Medicine; Tokyo, Japan 160-8582 (Kasuga)Search for more papers by this author, and Akira Kasuga, MDKeio University School of Medicine; Tokyo, Japan 160-8582 (Kawai)Keio University School of Medicine; Tokyo, Japan 160-8582 (Shimada)Keio University School of Medicine; Tokyo, Japan 160-8582 (Kasuga)Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-132-6-200003210-00024 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:The potent immunosuppressant FK506 (tacrolimus) has been widely used for transplantation (1). However, it remains unclear whether this agent is useful for all patients who require an immunosuppressed state.A 32-year-old Japanese diabetic woman had undergone living-related liver transplantation in June 1997 because of autoimmune cholangiopathy. She had had Hashimoto thyroiditis and suspected systemic lupus erythematosus. Elevated fasting plasma glucose (11.9 mmol/L) and hemoglobin A1c (7.3%) levels were first noted in December 1996. The 2-hour postprandial serum C-peptide level (1.07 nmol/L) indicated sufficient pancreatic β-cell function. At that time, the patient was negative for both glutamic acid ...References1. The U.S. Multicenter FK506 Liver Study Group. A comparison of tacrolimus (FK506) and cyclosporine for immunosuppression in liver transplantation. N Engl J Med. 1994;331:1110-5. CrossrefMedlineGoogle Scholar2. Awata T, Kuzuya T, Matsuda A, Iwamoto Y, Kanazawa Y. Genetic analysis of HLA class 2 alleles and susceptibility to type 1 (insulin-dependent) diabetes mellitus in Japanese subjects. Diabetologia. 1992;35:419-24. CrossrefMedlineGoogle Scholar3. Noguchi N, Takasawa S, Nata K, Tohgo A, Kato I, Ikehata F, et al . Cyclic ADP-ribose binds to FK506-binding protein 12.6 to release Ca 2+ from islet microsomes. J Biol Chem. 1997;272:3133-6. CrossrefMedlineGoogle Scholar4. Hirano Y, Fujihira S, Ohara K, Katsuki S, Noguchi H. Morphological and functional changes of islets of Langerhans in FK506 treated rats. Transplantation. 1992;53:889-94. CrossrefMedlineGoogle Scholar5. Baekkeskov S, Aanstoot HJ, Christgau S, Reetz A, Solimena M, Cascalho M, et al . Identification of the 64K autoantigen in insulin-dependent diabetes as the GABA-synthesizing enzyme glutamic acid decarboxylase. Nature. 1990;347:151-6. CrossrefMedlineGoogle Scholar Author, Article, and Disclosure InformationAffiliations: Keio University School of Medicine; Tokyo, Japan 160-8582 (Kawai)Keio University School of Medicine; Tokyo, Japan 160-8582 (Shimada)Keio University School of Medicine; Tokyo, Japan 160-8582 (Kasuga) PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByTacrolimusIMMUNE MODULATORSENDOCRINE AND METABOLIC ADVERSE EFFECTS OF NON-HORMONAL AND NON-METABOLIC DRUGSTacrolimusSuccessful treatment of myasthenia gravis with tacrolimusDrugs acting on the immune systemDiabetes mellitus: a major challenge in transplantationImpact of immunosuppressive regimes on posttransplant diabetes mellitusCurrent Awareness 21 March 2000Volume 132, Issue 6Page: 511KeywordsBlood plasmaCellsGeneralized anxiety disorderGlucoseImmunosuppressivesLiver transplantationProteinsThyroidTransplantationType 1 diabetes Issue Published: 21 March 2000 CopyrightCopyright © 2000 by American College of Physicians. All Rights Reserved.PDF DownloadLoading ...