tbuckley/cabot-search huggingface dataset:
Combined aspirin and clopidogrel treatment improves outcomes, study finds
Authors: D. Spurgeon
Journal: BMJ (2003)

The blood thinner clopidogrel, when used with aspirin, reduces the short term and long term risk of heart attack, stroke, and death among more than 12000 emergency department patients in 28 countries, a study shows.

The study by Dr Salim Yusuf and colleagues, in the rapid track section of the online version of Circulation , says that the drug showed beneficial effects within 24 hours of start of treatment and that the benefit continued for …
ANGIOTENSINOGEN M235T GENE VARIANTS AFFECT ENDOTHELIAL FUNCTION AND ARTERIAL STIFFNESS IN PATIENTS WITH ESSENTIAL HYPERTENSION
Authors: Emmanouil Androulakis, Dimitris Tousoulis, Evaggelos Chatzistamatiou, Nikolaos Papageorgiou, George Moustakas, Antigoni Miliou, Evaggelos Oikonomou, Gerasimos Siasos, Anastasios Giolis, Ioannis Kallikazaros, Christodoulos Stefanadis
Journal: Journal of the American College of Cardiology (2010)
A PORTABLE COMBINATION DOUCHE-CAN AND STERILIZER
Authors: Adam P. Leighton
Journal: JAMA (1913)

Believing that some of the readers ofThe Journalwho are engaged in the practice of obstetrics may be interested in a combination douche-can and sterilizer, I herewith give a plan and discription of one which to me is satisfactory and practical. It is easily carried in the ordinary 18 or 20-inch obstetric bag. Its width of 5 inches allows for ample room between the sides of the douch-can and the bag, where the bottles, pad, dressings and other obstetric necessities may be placed. In the douche-can may be placed the forceps, sutures, gloves and other instruments, so that all space in the bag is utilized. The instruments, gloves, etc., are place in the pan of the sterilizer and boiled, after which they are removed in the pan from the sterilizer. The brass cock, which is threaded and easily removed and which has been duly sterilized with the instruments, may
Physician Attitudes and Experience with Permit Applications for Concealed Weapons
Authors: John Pierson, Anthony J. Viera, Kathy K. Barnhouse, James A. Tulsky, Barak D. Richman, Adam O. Goldstein
Journal: New England Journal of Medicine (2014)

In many states, a physician's assessment of competency to carry a concealed weapon is required before a permit is issued. In a survey of North Carolina physicians, the majority reported that they could not adequately assess patients' ability to safely use a concealed weapon.
Sodium dependency of L-alanine absorption in canine Thiry-Vella loops
Authors: B. Fleshler, R. A. Nelson
Journal: Gut (1970)

The effect of sodium on the absorption of L-alanine <i>in vivo</i> was tested by measuring the absorption of L-alanine from Thiry-Vella loops in dogs. Solutions containing L-alanine (10 or 50 mM) sodium at concentrations of 0, 74, or 145 m-equiv/1 and mannitol, as needed to maintain isotonicity were instilled into the loops for 10 minutes. Similar studies were done with L-alanine 50 mM and either 0 or 145 m-equiv/1 of sodium for five minutes. Under all conditions absorption of alanine was significantly less from the solution initially free of sodium. Although these differences were statistically significant, the physiological significance was not great since the actual differences in amounts of L-alanine absorbed were small. Insorption of sodium was low from the fluid which initially had no sodium, but exsorption proceeded rapidly and was unaffected by the luminal sodium concentration. This resulted in a rapid rise of intraluminal sodium concentration when no sodium was initially present. This persistent exsorption of sodium was, therefore, adequate to provide sodium in the lumen to activate the sodium-dependent carrier, postulated on the basis of studies <i>in vitro.</i> These data <i>in vivo</i> are consistent with the view that sodium at the intraluminal surface is important in accelerating amino acid transport, but indicate that in the absence of added intraluminal sodium the gut mucosa itself, under normal circumstances, provides the sodium needed for L-alanine absorption.
Acute Effects of Alcohol in Patients with Congestive Heart Failure
Authors: BARRY H. GREENBERG
Journal: Annals of Internal Medicine (1982)

We evaluated the acute effects of moderate alcohol consumption in eight patients with New York Heart Association Functional Class III-IV congestive heart failure. Hemodynamic and echocardiographic variables were measured at baseline and then repeated at 30-minute intervals after ingestion of alcohol, 0.9 g/kg body weight, in the form of 80 proof vodka. Mean peak blood alcohol levels (±SE) at 60 minutes were 117 ± 8 mg/dL. A significant reduction in mean arterial pressure, pulmonary artery and pulmonary artery wedge pressures, and systemic vascular resistance occurred over the first 90 minutes. Neither cardiac index, stroke volume index, stroke work index, nor echocardiographic variables were significantly changed. In patients with heart failure, a single moderate dose of alcohol reduces afterload by dilating arterial resistance vessels. No evidence of acute deterioration in cardiac performance was seen. In such patients occasional consumption of moderate dose alcohol can be safely tolerated.
Long-Acting Sulfonamides In Urinary Tract Infection
Authors: A. T. K. Cockett
Journal: JAMA (1967)

<h3>To the Editor:—</h3> Dr. Harry Seneca has written an article entitled "Long-Acting Sulfonamides in Urinary Tract Infections" (<b>198</b>:975, 1966). I do not disagree with the content insofar as the sulfonamides are concerned. On page 979, Dr. Seneca states that nitrofurantoin does not give rise to biologically active tissue levels; yet the work we and others have published clearly demonstrates the presence of significant renal interstitial (renal lymph) concentrations of nitrofurantion.<sup>1-3</sup>In fact, these interstitial concentrations exceed the corresponding blood levels. Our published data also clearly show that the renal lymph concentrations of nitrofurantoin are biologically active and suppress growth of<i>Escherichia coli</i>. Sweeping statements such as Dr. Seneca's run the danger of ignoring recent advances, leaving the reader with an erroneous conclusion.
A Right to Health: The Problem of Access to Primary Medical Care
Authors: Amasa B. Ford
Journal: JAMA (1977)

This book is a documented evaluation of legislative and other social programs (most of which were launched during the 1960s) that aim to increase access to primary health care. Although the authors find some bright spots and useful lessons, they indict the fragmentary, uncoordinated, and inadequate way we have gone about this business.  Particularly wasteful has been the almost universal failure to include requirements for evaluation in new social legislation. The heart of the present book is the central section in which Charles Lewis, MD, a specialist in health services research, presents the limited data we have available with which to evaluate the various programs. Six of these he classifies as designed to improve the supply of services. Here the record is very disappointing. A marked increase in the numbers of physicians trained, practice commitment, with or without loan forgiveness, rural preceptorships for medical students, and the National Health Service
Palpable Spleens: Ten-Year Follow-Up
Authors: Franklin G. Ebaugh, O. Ross Mcintyre
Journal: Annals of Internal Medicine (1979)

Letters and Corrections1 January 1979Palpable Spleens: Ten-Year Follow-UpFRANKLIN G. EBAUGH JR., M.D., O. ROSS MCINTYRE, M.D.FRANKLIN G. EBAUGH JR., M.D.Search for more papers by this author, O. ROSS MCINTYRE, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-90-1-130_2 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: In 1967 we reported that 63 of 2200 (2.9%) freshmen at Dartmouth College had a palpable spleen at the time of routine physical examination (1). Fifty-eight of the students were found to have normal hematocrits, reticulocyte counts, blood smears, and heterophil titers. These students gave no history of disease and were asymptomatic. Four had infectious mononucleosis at the time of examination and one had a history of malaria. In the 58 without associated disease, there was no obvious difference in the prior frequency of infection or other illnesses compared to their classmates without palpable spleens. There was...References1. MCINTYREEBAUGH OF: Palpable spleens in college freshmen. Ann Intern Med 66:301-306, 1967 LinkGoogle Scholar2. JACOBMACDONALDJANDL HRJ: Regulation of spleen growth and sequestering function. J Clin Invest 42:1476, 1963 CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byAbdominal MassesChanges in liver and spleen volumes after living liver donation: A report from the adult-to-adult living donor liver transplantation cohort study (A2ALL)Why Does My Patient Have Lymphadenopathy or Splenomegaly?The SpleenThe Disappearing SpleenSplenomegaly: Investigation, diagnosis and managementSplenomegaly and SportsDetermination of Safe Return to Play for Athletes Recovering from Infectious MononucleosisHepatomegaly and splenomegalySurgical aspects of splenic disease and lymphomaMalignant Splenic LesionsSplenomegaly at a United States County Hospital: Diagnostic Evaluation of 170 PatientsSplenomegaly at a United States County Hospital: Diagnostic Evaluation of 170 PatientsHypersplenismus und Splenektomie bei inneren KrankheitenDie Milz und ihre FunktionsstörungenThe Periodic Physical Examination in Asymptomatic AdultsSylvia K. Oboler, MD, F. Marc LaForce, MDTrue idiopathic splenomegaly - a distinct clinical entity 1 January 1979Volume 90, Issue 1Page: 130-131KeywordsBloodBlood countsHematocritInfectious diseasesMalariaReticulocytesSpleen Issue Published: 1 January 1979 PDF downloadLoading ...
HICH LEITOCYTOSIS (LEUKAEMOID REACTIONS?) IN DERMATITIS HERPETIFORMIS.
Authors: ZVI EVEN-PAZ, FELIX SAGHER
Journal: British Journal of Dermatology (1959)

Journal Article HICH LEITOCYTOSIS (LEUKAEMOID REACTIONS?) IN DERMATITIS HERPETIFORMIS. Get access ZVI EVEN‐PAZ, MR., Ch. B., ZVI EVEN‐PAZ, MR., Ch. B. The Department of Dermatology and Venereology, Hadassah University Hospital Jerusalem, Israel Search for other works by this author on: Oxford Academic Google Scholar FELIX SAGHER, M.D. FELIX SAGHER, M.D. The Department of Dermatology and Venereology, Hadassah University Hospital Jerusalem, Israel Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 71, Issue 10, 1 October 1959, Pages 325–334, https://doi.org/10.1111/j.1365-2133.1959.tb13358.x Published: 01 October 1959
Mammalian Target of Rapamycin Repression by 3,3′-Diindolylmethane Inhibits Invasion and Angiogenesis in Platelet-Derived Growth Factor-D–Overexpressing PC3 Cells
Authors: Dejuan Kong, Sanjeev Banerjee, Wei Huang, Yiwei Li, Zhiwei Wang, Hyeong-Reh Choi Kim, Fazlul H. Sarkar
Journal: Cancer Research (2008)

Abstract Platelet-derived growth factor-D (PDGF-D) is a newly recognized growth factor known to regulate many cellular processes, including cell proliferation, transformation, invasion, and angiogenesis. Recent studies have shown that PDGF-D and its cognate receptor PDGFR-β are expressed in prostate tumor tissues, suggesting that PDGF-D might play an important role in the development and progression of prostate cancer. However, the biological role of PDGF-D in tumorigenesis remains elusive. In this study, we found that PDGF-D–overexpressing PC3 cells (PC3 cells stably transfected with PDGF-D cDNA and referred to as PC3 PDGF-D) exhibited a rapid growth rate and enhanced cell invasion that was associated with the activation of mammalian target of rapamycin (mTOR) and reduced Akt activity. Rapamycin repressed mTOR activity and concomitantly resulted in the activation of Akt, which could attenuate the therapeutic effects of mTOR inhibitors. In contrast, B-DIM (BR-DIM from Bioresponse, Inc.; a chemopreventive agent) significantly inhibited both mTOR and Akt in PC3 PDGF-D cells, which were correlated with decreased cell proliferation and invasion. Moreover, conditioned medium from PC3 PDGF-D cells significantly increased the tube formation of human umbilical vein endothelial cells, which was inhibited by B-DIM treatment concomitant with reduced full-length and active form of PDGF-D. Our results suggest that B-DIM could serve as a novel and efficient chemopreventive and/or therapeutic agent by inactivation of both mTOR and Akt activity in PDGF-D–overexpressing prostate cancer. [Cancer Res 2008;68(6):1927–34]
EARLY ASPIRATIONS IN ACUTE PLEURITIS.Read in the Section of Practice of Medicine, at the Forty-fourth Annual Meeting of the American Medical Association.
Authors: E. J. C. MINARD
Journal: JAMA (1893)

Pleuritis is a disease as old as medicine and common as spring and autumn, but as many mistakes, perhaps, have been made in the diagnosis and treatment of it as have been made in the more obscure and less common diseases. In the present light of medical science, blunders or neglect are inexcusable in treatment or operation in any branch of medicine. The authorities teach that this disease will run its course often with little or no treatment, and is easy of diagnosis. So one may say of scarlet fever, sometimes. But any disease, common, obscure or rare, which will vitiate or interfere with the issuing of a life insurance policy, may not be considered slightingly, or treatment assumed without duly considering the gravity of the case, with the many stages, types, complications and dangers. In the cities of the Atlantic seacoast, especially New York and Brooklyn, pleuritis becomes one
Modulation of MEK activity during G‐CSF signaling alters proliferative versus differentiative balancing
Authors: Michael A. Baumann, Cassandra C. Paul, Susan Lemley‐Gillespie, Marlo Oyster, Julian Gomez‐Cambronero
Journal: American Journal of Hematology (2001)

Abstract Previous studies of the granulocyte colony stimulating factor (G‐CSF) receptor have demonstrated that discrete signals direct proliferative and maturation signaling. Receptor deletion/mutant studies have shown that although activation of the ras ‐mitogen activated protein (MAP) kinase pathway is necessary for G‐CSF directed proliferation, it is not necessary for maturation induced by this cytokine. We have assessed the effects of selective inhibition or overexpression of MAP kinase kinase (MEK) in a cell line model of G‐CSF‐induced neutrophil progenitor growth. Using the human G‐CSF responsive MPD cell line, we specifically inhibited MEK using PD 98059 and also transfected MPD cells with a constitutively active MEK construct. We then exposed the cells to G‐CSF and assessed the effects of MEK inhibition and forced expression on proliferation and differentiation. Inhibition of MEK followed by G‐CSF stimulation consistently resulted in an early 2.5‐fold increase in morphologically differentiated neutrophils expressing CD11b and CD16 and containing lactoferrin over that produced by G‐CSF alone. MEK inhibition alone had little effect on the differentiation stage of these cells, although proliferation was impaired. Forced expression of activated MEK resulted in a three‐ to five‐fold decrease in differentiated, lactoferrin containing neutrophilic cells resultant from G‐CSF induction, and a commensurate increase in cell proliferation. These observations suggest that modulation of MAPK activation may be a control point for altering the balance between proliferation and differentiation in response to G‐CSF. Physiologically, this control is likely exerted by costimulatory cytokines. Am. J. Hematol. 68:99–105, 2001. Published 2001 Wiley‐Liss, Inc.
Rates of peripheral arterial occlusive disease in patients with chronic myeloid leukemia in the chronic phase treated with imatinib, nilotinib, or non-tyrosine kinase therapy: a retrospective cohort analysis
Authors: F J Giles, M J Mauro, F Hong, C-E Ortmann, C McNeill, R C Woodman, A Hochhaus, P D le Coutre, G Saglio
Journal: Leukemia (2013)
Clonal chromosomal abnormalities in CD34+/CD38− hematopoietic cells from cytogenetically normal chronic myeloid leukemia patients with a complete cytogenetic response to tyrosine kinase inhibitors
Authors: T Bumm, J Deininger, A H Newell, H Lawce, S Olson, M Mauro, B Druker, M Deininger
Journal: Leukemia (2010)
Genetic modifiers of sickle cell anemia in the BABY HUG cohort: influence on laboratory and clinical phenotypes
Authors: Vivien A. Sheehan, Zhaoyu Luo, Jonathan M. Flanagan, Thad A. Howard, Bruce W. Thompson, Winfred C. Wang, Abdullah Kutlar, Russell E. Ware
Journal: American Journal of Hematology (2013)

The recently completed BABY HUG trial investigated the safety and efficacy of hydroxyurea in infants with sickle cell anemia (SCA). To investigate the effects of known genetic modifiers, genomic DNA on 190 randomized subjects were analyzed for alpha thalassemia, beta-globin haplotype, polymorphisms affecting endogenous fetal hemoglobin (HbF) levels (XmnI, BCL11A, and HBS1L-MYB), UGT1A1 promoter polymorphisms, and the common G6PD A(-) mutation. At study entry, infants with alpha thalassemia trait had significantly lower mean corpuscular volume, total bilirubin, and absolute reticulocyte count. Beta-globin haplotypes associated with milder disease had significantly higher hemoglobin and %HbF. BCL11A and XmnI polymorphisms had significant effects on baseline HbF, while UGT1A1 promoter polymorphisms significantly influenced baseline serum bilirubin. At study exit, subjects randomized to placebo still exhibited laboratory effects of alpha thalassemia and other modifiers, while those assigned hydroxyurea had treatment effects that exceeded most genetic influences. The pain phenotype was influenced by HbF modifiers in both treatment groups. These data document that genetic polymorphisms do modify laboratory and clinical phenotypes even in very young patients with SCA. The hydroxyurea effects are more potent, however, indicating that treatment criteria should not be limited to certain genetic subsets, and supporting the use of hydroxyurea for all young patients with SCA.
Next-Generation Strategies for Hereditary Colorectal Cancer Risk Assessment
Authors: Matthew B. Yurgelun
Journal: Journal of Clinical Oncology (2015)

Article Tools ONCOLOGY GRAND ROUNDS Article Tools OPTIONS & TOOLS Export Citation Track Citation Add To Favorites Rights & Permissions COMPANION ARTICLES No companion articles ARTICLE CITATION DOI: 10.1200/JCO.2014.58.9895 Journal of Clinical Oncology - published online before print January 5, 2015 PMID: 25559814 Next-Generation Strategies for Hereditary Colorectal Cancer Risk Assessment Matthew B. YurgelunxMatthew B. YurgelunSearch for articles by this author Show More Dana-Farber Cancer Institute, Boston, MA https://doi.org/10.1200/JCO.2014.58.9895 First Page Full Text PDF Figures and Tables © 2015 by American Society of Clinical Oncology
Unsuspected fractures of the femoral neck in patients with chronic hip pain due to rheumatoid arthritis.
Authors: P L Williams, N K Amin, A Young
Journal: BMJ (1986)

In patients with rheumatoid arthritis pain and loss ofmobility due to diseased hip joints may disguise a superimposed fracture of the neck of the femur, particularly when there is no history of trauma. Case reportsThe table summarises five cases of rheumatoid arthritis in which a fracture of the neck of the femur was initially unsuspected.All five of the patients were postmenopausal women; three had received long term corticosteroids.
Massive haemolysis caused by rifampicin.
Authors: S Lakshminarayan, S A Sahn, L D Hudson
Journal: BMJ (1973)

zygous Hb C disease show abnormal physical properties in vitro-their viscosity is higher than that of normal cells and they appear to be more rigid.These differences are exaggerated when the osmolality of the suspending solution is increased (Charache et al., 1967).Given these in-vitro observa- tions, it may be postulated that alterations in the physical properties of the red cells of this patient produced by the hyperosmolar state may have resulted both in ischaemic mono- neuritis multiplex due to occlusion of vasa nervorum and acute renal failure due to intravascular damage or sludging within the renal glomeruli.
High-grade T-cell lymphoma complicating B-cell chronic lymphocytic leukemia: An unusual manifestation of ?Richter's syndrome?
Authors: Alex Novogrudsky, Edward L. Amorosi, Susan R. S. Gottesman
Journal: American Journal of Hematology (2001)

Approximately 3% of patients with B-cell chronic lymphocytic leukemia (CLL) develop a high-grade large-cell lymphoma consistent with Richter's Syndrome. In most cases, these lymphomas are of B-cell origin and are believed to arise by clonal evolution from the CLL cells. We present a case of a patient with a 10-year history of B-CLL who developed an aggressive large-cell lymphoma, confirmed by immunophenotype to be of T-cell origin. We suggest that in patients with CLL, immunodysregulation can result in the proliferation of T cells, which may mutate and result in the development of a new malignant clone. Am. J. Hematol. 66:203–206, 2001. © 2001 Wiley-Liss, Inc.
Studies on the Mechanism of Increased Plasma Triglyceride Levels Induced by Oral Contraceptives
Authors: William R. Hazzard, Michael J. Spiger, John D. Bagdade, Edwin L. Bierman
Journal: New England Journal of Medicine (1969)

Increases in plasma triglyceride levels were observed in normal young women treated for two weeks with an oral contraceptive containing ethinyl estradiol and medroxyprogesterone. The mechanism of this phenomenon may be related to an observed decrease in postheparin lipolytic activity and impaired plasma triglyceride removal. At the same time serum insulin levels increased, perhaps stimulating endogenous hepatic triglyceride synthesis and secretion into plasma.
Autoimmune thyroid disease and antiphospholipid antibodies
Authors: Dan Nabriski, Martin Ellis, Rosanne Ness-Abramof, Menachem Shapiro, Louis Shenkman
Journal: American Journal of Hematology (2000)

Objective Autoimmune thyroid disease (ATD) is associated with circulating autoantibodies reactive with epitopes on thyroid tissue and that are thought to be pathogenic in the development of these diseases. Antiphospholipid antibodies (APLA) are a family of immunoglobulins that recognize a variety of plasma proteins in association with anionic phospholipids. These antibodies may lead to a number of clinical syndromes including venous and arterial thromboses, thrombocytopaenia, and recurrent fetal loss. We have studied the prevalence of APLA in patients with ATD and have determined the prevalence of the APLA syndrome among APLA-positive patients. Design The study was a retrospective survey of patients with autoimmune thyroid disease attending the endocrinology clinic of a tertiary care academic hospital. Patients and Measurements One hundred and thirty patients with autoimmune thyroid disease from the endocrinology clinic at our hospital were studied. 84% had chronic thyroiditis and 16% had Graves' disease. Free T4 and thyroid stimulating hormone (TSH) levels, antimicrosomal and antithyroglobulin antibodies, and an antiphospholipid antibody test were performed on all subjects. Results 43% of patients with chronic thyroiditis and 43% of patients with Graves' disease were APLA positive, with an overall rate of 43% APLA positivity among patients with ATD. Of the 56 patients that were APLA positive, forty-eight (86%) had APLA of the IgG subtype, four (7%) had IgM antibodies, and nine (16%) had both IgG and IgM antibodies. None of the patients had clinical evidence of the APLA syndrome. Conclusions We conclude that the prevalence of APLA in ATD is increased compared to healthy individuals but that this is likely to be an epiphenomenon, However, prolonged follow up is necessary in order to determine the true clinical significance of these antibodies in ATD patients. Am. J. Hematol. 64:73–75, 2000. © 2000 Wiley-Liss, Inc.