tbuckley/cabot-search huggingface dataset:
ERβ Impedes Prostate Cancer EMT by Destabilizing HIF-1α and Inhibiting VEGF-Mediated Snail Nuclear Localization: Implications for Gleason Grading
Authors: Paul Mak, Irwin Leav, Bryan Pursell, Donggoo Bae, Xiaofang Yang, Cherie A. Taglienti, Lindsey M. Gouvin, Vishva M. Sharma, Arthur M. Mercurio
Journal: Cancer Cell (2010)
Anaphylaxis Associated With Chymopapain Injections
Authors: George E. Battit
Journal: JAMA (1985)

<h3>To the Editor.—</h3> I must express my disagreement with Dr Walter Whisler's opinion that "many cases of anaphylaxis that have been reported are really a reaction to anesthetic drugs."<sup>1</sup>Anaphylaxis is a rare phenomenon in general and even more rare in patients receiving general anesthesia. For example, the first reported case of anaphylaxis to penicillin in a patient receiving anesthesia was in 1970,<sup>2</sup>when the incidence of allergy to penicillin was being reported as approximately 4% in the general population. Among the anesthetic drugs in use in this country today, the incidence of anaphylaxis is even more rare. The entire world literature records slightly more than 40 documented cases of anaphylactic reaction to thiopental (Pentothal), which has been used in millions of patients. To my knowledge, true anaphylaxis to inhalation agents (eg, halothane, enflurane, isoflurane, and nitrous oxide) has not been reported. Anaphylaxis associated with local anesthetic agents
ABC of sleep disorders. Sleep and sleep problems in elderly people.
Authors: C G Swift, C M Shapiro
Journal: BMJ (1993)

The reasons for special consideration of sleep and its problems among elderly people are: * Increased dissatisfaction with the quality of sleep, complaints about insomnia, and use ofhypnotic drugs, particularly among women * Sleep architecture changes with increasing age -* Insomnia may be a marker ofphysical or psychological disorders, and of JAA ' , _social or environmental problems * The importance ofthe beneficial effects ofhealthy sleep, particularly of * tt-,7.optimal central nervous system performance, during the day * There is a need for a more circumspect and thoughtful approach to sleep problems in later life.alence ofsleep problems and use ofhypnotic drugs ..~~~~..Surveys in Britain and the United States ... 11 p :s, ..** ,,*uring the 1 960s and 1970s showed a positive
5-Azacytidine treatment sensitizes tumor cells to T-cell mediated cytotoxicity and modulates NK cells in patients with myeloid malignancies
Authors: A O Gang, T M Frøsig, M K Brimnes, R Lyngaa, M B Treppendahl, K Grønbæk, I H Dufva, P thor Straten, S R Hadrup
Journal: Blood Cancer Journal (2014)

Treatment with the demethylating agent 5-Azacytidine leads to prolonged survival for patients with myelodysplastic syndrome, and the demethylation induces upregulation of cancer-testis antigens. Cancer-testis antigens are well-known targets for immune recognition in cancer, and the immune system may have a role in this treatment regimen. We show here that 5-Azacytidine treatment leads to increased T-cell recognition of tumor cells. T-cell responses against a large panel of cancer-testis antigens were detected before treatment, and these responses were further induced upon initiation of treatment. These characteristics point to an ideal combination of 5-Azacytidine and immune therapy to preferentially boost T-cell responses against cancer-testis antigens. To initiate such combination therapy, essential knowledge is required about the general immune modulatory effect of 5-Azacytidine. We therefore examined potential treatment effects on both immune stimulatory (CD8 and CD4 T cells and Natural Killer (NK) cells) and immune inhibitory cell subsets (myeloid-derived suppressor cells and regulatory T cells). We observed a minor decrease and modulation of NK cells, but for all other populations no effects could be detected. Together, these data support a strategy for combining 5-Azacytidine treatment with immune therapy for potential clinical benefit.
THE RELATION OF MODERN DENTISTRY TO THE TUBERCULOSIS PROBLEM
Authors: S. ADOLPHUS KNOPF
Journal: JAMA (1910)

Fifty years ago there was really no dental science. The tooth-extractor of that day, picturesquely attired, with his long flowing hair, who went from town to town with a brass band and extracted teeth in the market-place, while in the majority of cases he was a shrewd business man and showman and knew human nature, very rarely had any scientific training or, if he had it, he did not apply it to his calling. The preservation of the teeth and the tedious processes of filling a cavity and doing crown and bridgework were unknown to him. He did not care to preserve teeth, and the more he extracted the more lucrative was his business. It must be said to the glory of American achievements that dental science, the art of preserving teeth by a truly scientific method, had its birth in this country. The European dentist has for the last
A Polymorphism in the<i>CTGF</i>Promoter Region Associated with Systemic Sclerosis
Authors: Carmen Fonseca, Gisela E. Lindahl, Markella Ponticos, Piersante Sestini, Elisabetta A. Renzoni, Alan M. Holmes, Paolo Spagnolo, Panagiotis Pantelidis, Patricia Leoni, Neil McHugh, Carmel J. Stock, Xu Shi-Wen, Christopher P. Denton, Carol M. Black, Kenneth I. Welsh, Roland M. du Bois, David J. Abraham
Journal: New England Journal of Medicine (2007)

Systemic sclerosis (scleroderma) is a life-threatening autoimmune disease that is characterized by the presence of specific autoantibodies and fibrosis of the skin and major internal organs.We genotyped a polymorphism (G-945C) in the promoter of the connective-tissue growth factor (CTGF) gene in 1000 subjects in two groups: group 1, consisting of 200 patients with systemic sclerosis and 188 control subjects; and group 2, consisting of 300 patients with systemic sclerosis and 312 control subjects. The combined groups represented an estimated 10% of patients with systemic sclerosis in the United Kingdom. We tested the effect of the polymorphism on the transcription of CTGF.The GG genotype was significantly more common in patients with systemic sclerosis than in control subjects in both groups, with an odds ratio for the combined group of 2.2 (95% confidence interval [CI], 1.5 to 3.2; P<0.001 for trend). Analysis of the combined group of patients with systemic sclerosis showed a significant association between homozygosity for the G allele and the presence of anti-topoisomerase I antibodies (odds ratio, 3.3; 95% CI, 2.0 to 5.6; P<0.001) and fibrosing alveolitis (odds ratio, 3.1; 95% CI, 1.9 to 5.0; P<0.001). We observed that the substitution of cytosine for guanine created a binding site of the transcriptional regulators Sp1 and Sp3. The C allele has high affinity for Sp3 and is associated with severely reduced transcriptional activity. A chromatin immunoprecipitation assay showed a marked shift in the ratio of Sp1 to Sp3 binding at this region, demonstrating functional relevance in vivo.The G-945C substitution represses CTGF transcription, and the -945G allele is significantly associated with susceptibility to systemic sclerosis.
A phase 2 study of MK-0457 in patients with BCR-ABL T315I mutant chronic myelogenous leukemia and philadelphia chromosome-positive acute lymphoblastic leukemia
Authors: J F Seymour, D W Kim, E Rubin, A Haregewoin, J Clark, P Watson, T Hughes, I Dufva, J L Jimenez, F-X Mahon, P Rousselot, J Cortes, G Martinelli, C Papayannidis, A Nagler, F J Giles
Journal: Blood Cancer Journal (2014)

Aurora kinase overexpression has been observed in patients with hematologic malignancies. MK-0457, a pan-aurora kinase inhibitor that also inhibits the ABL T315I mutant, was evaluated to treat patients with chronic myelogenous leukemia (CML) or Philadelphia chromosome (Ph+) acute lymphoblastic leukemia (ALL) with the T315I mutation. Adults with Ph+ chronic phase (CP)-, accelerated phase (AP)- or blast phase (BP)-CML, or ALL and documented BCR-ABL T315I mutation were treated with a 5-day continuous infusion of MK-0457 administered every 14 days at 40 mg/m(2)/h, 32 mg/m(2)/h or 24 mg/m(2)/h. Fifty-two patients (CP, n=15; AP, n=14; BP, n=11; Ph+ ALL, n=12) were treated. Overall, 8% of patients achieved major cytogenetic response; 6% achieved unconfirmed complete or partial response; 39% had no response. Two patients (CP CML) achieved complete hematologic response. No patients with advanced CML or Ph+ ALL achieved major hematologic response. The most common adverse event (AE) was neutropenia (50%). The most common grade 3/4 AEs were neutropenia (46%) and febrile neutropenia (35%). MK-0457 demonstrated minimal efficacy and only at higher, intolerable doses; lower doses were tolerated and no unexpected toxicities were observed. These data will assist in the development of future aurora kinase inhibitors and in the selection of appropriate target patient populations.
Effect of 6-Mercaptopurine on Endotoxin Tolerance*
Authors: Sheldon M. Wolff, John H. Mulholland, Stanley B. Ward, Melvin Rubenstein, Peter D. Mott
Journal: Journal of Clinical Investigation (1965)

sera low in antibody passively transfer as much tolerance as the control sera, which contain significantly more antibody.In addition, some of the immunochemical and physicochemical charac- teristics of the type of antibody elicited are de- scribed. MethodsRabbits.Over 200 New Zealand albino rabbits of both sexes and weighing approximately 2 kg each were used.Animals were housed and tested in air-conditioned rooms.Bleedings.All bleedings from marginal ear veins were obtained 24 hours after drug or endotoxin injection or both.The sera were separated by centrifugation and stored at -200 C.
Home versus hospital intravenous antibiotic therapy in the treatment of young adults with cystic fibrosis
Authors: MN Pond, M Newport, D Joanes, SP Conway
Journal: European Respiratory Journal (1994)

We wanted to investigate whether home intravenous antibiotic treatment of pulmonary exacerbations of cystic fibrosis is as effective as treatment in hospital. The case records of all patients attending the Leeds adult cystic fibrosis clinic were reviewed to identify those who had received home intravenous antibiotic treatment. All home treatments undertaken were included. For each home treatment, the temporally closest hospital treatment for that patient was then selected for comparison and the changes with treatment in peak expiratory flow rate (PEFR), forced vital capacity (FVC), forced expiratory volume in one second (FEV1), C-reactive protein (CRP), plasma viscosity, total white cell count, absolute neutrophil count, total immunoglobulin G (IgG) concentration, chest X-ray score (Northern), clinical score, Shwachman-Kulczyki score and weight were analysed for differences between home treatment and hospital treatment. Fifty one paired home/hospital treatments in 25 patients were compared. The improvement in total white cell count was found to be significantly greater in the hospital group, but the difference was very small. The improvements in absolute neutrophil count, and all the other measured variables, were the same in the two groups. Treatment of exacerbations of cystic fibrosis at home or in hospital is, thus, equally effective given proper patient selection and adequate monitoring of the response to treatment.
An Address on the Spread, Probable Mode of Infection, and Prophylaxis of Leprosy
Authors: L. Rogers
Journal: BMJ (1922)

MODE:-OF INFt-OTI10N4 AND" PROP-1-tlAXIS 6F01?LF" PROSY.[MDc ORA o of operation in this case would be considerable owing 'to the frailty of the patient's general cQndition and her inability, to accomplish much exertion on account of, the cardiac condition.These are but examples of certain classes of cases in wlich biliary drainage by the duodenal tube has given satisfactory results.There seems to be no doubt that there is a definite field of usefulness for it,.and more extended experience will probably give indications for its further development.
Hyponatremic Encephalopathy After Endometrial Ablation
Authors: Terence M. O'Connor
Journal: JAMA (1994)

<h3>To the Editor.</h3> —The article by Drs Arieff and Ayus<sup>1</sup>on the complications of operative hysteroscopy provides yet another account of potentially life-threatening complications of a procedure that is gaining popularity. At Physicians' Daysurgery Center, an outpatient surgical unit in Dallas, Tex, we began performing hysteroscopic surgery in May 1992. Over the course of the first 7 months, 49 of these procedures were done. It became apparent that there was a high rate of complications related to fluid absorption, including three patients who developed pulmonary edema. As serial sodium determinations are a late indicator of fluid absorption and usually not available in a timely manner, and measurement of instillation and recovery of irrigant are difficult and unreliable, other methods need to be looked at to measure intraoperative fluid absorption. Investigators in Sweden have used ethanol-containing irrigation fluid, combined with end-tidal breath alcohol analysis for TURP.<sup>2-5</sup>Hulten et al<sup>1</sup>showed
Early Systolic Clicks due to Mitral Valve Prolapse
Authors: ADOLPH M. HUTTER, ROBERT E. DINSMORE, JAMES T. WILLERSON, ROMAN W. DESANCTIS
Journal: Circulation (1971)

Four patients had evidence that mitral valve prolapse was the etiology of isolated early systolic clicks that were "ejection" in timing, that is, within 80 msec of the first heart sound (S 1 ). Phonocardiography demonstrated movement of the click closer to S 1 (three patients) with no change (three patients) or an increase in click amplitude (one patient) on inspiration. Earlier movement of systolic clicks on inspiration is a known feature of midsystolic clicks related to mitral valve prolapse but not of true aortic ejection sounds. In three patients the early systolic click showed a variable relation to the carotid upstroke, suggesting that the two events were not related. The click of the fourth patient occurred after the carotid upstroke. In one patient the click could be brought out by standing. Apical holosystolic murmurs could be elicited in all patients. Left- and right-heart catheterizations and left ventricular angiograms revealed no evidence of semilunar valve or great vessel root abnormality. Three patients had mitral valve prolapse and mitral regurgitation on left ventriculogram. The cineangiogram on one patient demonstrated maximal prolapse of the mitral valve just before opening of the aortic valve and coincident with the timing of the click. An isolated early systolic click may be due to mitral valve prolapse rather than to the usual ejection phenomena.
Response:Re: Adaptive Therapy for Androgen-Independent Prostate Cancer: A Randomized Selection Trial of Four Regimens
Authors: R. E. Millikan, C. J. Logothetis, P. F. Thall
Journal: JNCI Journal of the National Cancer Institute (2008)

We commend Thall et al. ( 1 ) for their report on a four-arm crossover randomized phase II study of complex multiagent chemotherapy regimens in men with castration-resistant prostate cancer.The sequentially randomized design proposed by Thall et al. ( 1) is an attractive method that may enhance our ability to select a potentially active new regimen that deserves further testing.Indeed, they show that this design is feasible.This study was conducted before the US Food and Drug Administration approval of docetaxel and prednisone, which demonstrated improved overall survival and palliative ability in this population ( 2 ).Combination chemotherapy regimens in prostate cancer, which have been studied for many years, culminated in the Southwest Oncology 99-16 randomized phase III trial,
More on Drug Fever
Authors: JOSEPH HERMAN
Journal: Annals of Internal Medicine (1987)

Letters and Corrections1 November 1987More on Drug FeverJOSEPH HERMAN, M.D.JOSEPH HERMAN, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-107-5-787_2 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: The series reported by Mackowiak and LeMaistre (1) is not necessarily representative of patients with drug fever. The authors' definition of the disorder is " . . . fever coinciding with the administration of a drug and disappearing after discontinuation of the drug when no other cause for the fever could be ascertained after a careful physical examination and appropriate laboratory study." In their literature search, which covered 22 years, they restricted themselves to "fever" as the major descriptor with the subheading "classification," thus excluding many reactions fulfilling their criteria but appearing under headings such as "hepatitis,"...References1. MACKOWIAKLEMAISTRE PC. Drug fever: a critical appraisal of current concepts. Ann Intern Med. 1987;106:728-33. LinkGoogle Scholar2. DEISSEROTHMORGANROTHWINOKUR AJS. Quinidine-induced liver disease. Ann Intern Med. 1972;77:595-7. LinkGoogle Scholar3. MURPHYRYMER PW. Quinidine-induced liver disease? Ann Intern Med. 1973;78:785-6. LinkGoogle Scholar4. CHAJEKLEHRERGELTNERLEVIJ TBDI. Quinidine-induced granulomatous hepatitis. Ann Intern Med. 1974;81:774-6. LinkGoogle Scholar5. HERMANBASSAN JH. Liver injury due to quinidine. JAMA. 1975;234:310-1. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: JOSEPH HERMAN, M.D.Affiliations: Faculty of the Health Sciences Ben-Gurion University Beersheba Israel PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 November 1987Volume 107, Issue 5Page: 787-788KeywordsDrug administrationDrugsFeversHepatitisPatient advocacyResearch laboratories ePublished: 1 December 2008 Issue Published: 1 November 1987 PDF downloadLoading ...
ATRIAL MECHANICAL ABNORMALITIES ON SPECKLE TRACKING ECHOCARDIOGRAPHY CORRELATE WITH DEGREE OF FIBROSIS IN PATIENTS WITH ATRIAL FIBRILLATION
Authors: Mahek Mirza, Panupong Jiamsripong, Marek Belohlavek, Louis Lanza, Francisco Arabia, Win-Kuang Shen, Arshad Jahangir
Journal: Journal of the American College of Cardiology (2012)
Harm minimisation for drug misusers.
Authors: N. Payne, P. Amoroso
Journal: BMJ (1992)

transmission should therefore be explored.As cases in infants now seem to be making a consider- able contribution to endemic transmission (table ), one approach would be to offer infants early measles vaccination before giving measles, mumps, and rubella vaccine in the second year of life.Studies to determine the serological response to early vaccination in infants of vaccinated and naturally immune mothers and the accuracy of a clinical diagnosis of measles in infants and older age groups are under way, together with theoretical studies to explore the impact of such a strategy.An epidemiologically and logistically different approach to routinely offering two doses would be to attempt to vaccinate all subjects in a wide age range within a short time and thereby interrupt transmission.This has recently been done in the English speaking Caribbean, where over 95% of all children aged 1-15 in eight of the 17 islands were vaccinated within one month.'To ensure elimination this initiative must be repeated periodically, the interval and targeted age groups being decided on the basis of epidemiological data such as the age specific prevalence of the antibody,6 and results of theoretical studies.Clearly, further work is required to provide a sound scientific basis for deciding future policy.We suggest that in the short term the cost effectiveness of offering measles, mumps, and rubella vaccine to secondary school children should be decided locally on the basis of a district's previous uptake of measles vaccine and present age specific notification rates.
Landmines: time for an international ban
Authors: J. Pearn
Journal: BMJ (1996)

Anti-personnel landmines remain one of the unmet challenges of preventive medicine. In the aftermath of modern civil and international conflict, civilians—especially children—continue to be killed long after the end of hostilities.1 2 Many victims are not recorded in official statistics. None the less, estimates place the current death rate at some 800 people a month, with another 1000-2000 surviving each month with blast injuries and consequent disability.1 At least 26 of the estimated 200 nations of the world have landmines seeded over their surface, and many other countries have a role in their manufacture, sale, and use. Even if an international moratorium on the manufacture and use of anti-personnel mines were achieved now, landmine clearance will take centuries.3

The case against the continued production and use of antipersonnel mines, like that against poison gas and biological warfare, is their indiscriminate effects on civilians and children. The profession of arms, like all professions, has evolved a code of ethics,4 with the underlying ethos that even when all attempts to maintain peace have failed, when peoples or nations go to war, it is still possible to prosecute combat at a …
Abnormal Electrocardiogram Without Heart Disease
Authors: Moshe Steier
Journal: JAMA (1973)

<h3>To the Editor.—</h3> Unusual electrocardiographic pattern may arise from extracardiac body movements and electrical or mechanical interferences.<sup>1,2</sup> Recently we observed an unusual electrocardiogram simulating "non specific ST changes" in a 7-year-old boy who has apparently no heart disease. This (Figure, top) was thought to be abnormal until a second ECG (bottom) using another machine, showed a normal record. This case illustrates again that extracardiac factors should be considered when evaluating electrocardiographic abnormalities.
Altered Breathing Pattern after Prenatal Nicotine Exposure in the Young Lamb
Authors: Ola Hafström, Joseph Milerad, Håkan W. Sundell
Journal: American Journal of Respiratory and Critical Care Medicine (2002)

Maternal smoking during pregnancy is a risk factor for sudden fetal and infant death as well as obstructive airway disease in childhood. Fetal nicotine exposure affects organ development. The aim of the present study was to investigate effects of fetal nicotine exposure on lung function in young lambs. Nine unanesthetized, awake, prenatally nicotine-exposed lambs (N) (approximate maternal dose: 0.5 mg/kg) and 12 nonexposed control lambs (C) were studied repeatedly for 5 weeks after birth using a pneumotachograph and a computerized method for breath-by-breath determinations. N and C lambs had similar minute ventilation but a markedly different breathing pattern. At both 5 and 21 days, average age, N lambs had significantly lower tidal volumes and higher respiratory rates than C lambs. Inspiratory drive (P0.1) and effective impedance were significantly higher in N lambs compared with C lambs only at 5 days. Prenatal nicotine exposure appears to have long-term effects on the postnatal breathing pattern, suggesting altered lung function, e.g., increased airway resistance, decreased lung compliance, or both. The increased inspiratory drive is most likely secondary to increased impedance of the respiratory system. These changes are most marked close to birth but persist during the initial postnatal period.
Epigenome analyses using BAC microarrays identify evolutionary conservation of tissue-specific methylation of SHANK3
Authors: Tsui-Ting Ching, Alika K Maunakea, Peter Jun, Chibo Hong, Giuseppe Zardo, Daniel Pinkel, Donna G Albertson, Jane Fridlyand, Jian-Hua Mao, Ksenya Shchors, William A Weiss, Joseph F Costello
Journal: Nature Genetics (2005)