tbuckley/cabot-search huggingface dataset:
Campylobacter on Campuses
Authors: ANDREW A. VERNON
Journal: Annals of Internal Medicine (1984)

Letters and Corrections1 April 1984Campylobacter on CampusesANDREW A. VERNON, M.D., RAY N. JARVIS, P.A.-C., JAMES F. MORGAN, M.D., MIRIAM G. ROGERS, M.D.ANDREW A. VERNON, M.D.Search for more papers by this author, RAY N. JARVIS, P.A.-C.Search for more papers by this author, JAMES F. MORGAN, M.D.Search for more papers by this author, MIRIAM G. ROGERS, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-100-4-615_1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: We read with interest the letter of Murray (1) regarding the frequency of campylobacter enteritis at the University of California at San Diego. At the Emory University Student Health Service in Atlanta, we have seen a similar increase in the laboratory diagnosis of campylobacter enteritis after the introduction of appropriate culture methods in 1980.In the 9-month academic year 1982 to 1983 our Health Services, which served 7765 enrolled students, found 47 stool cultures positive forCampylobacter jejuniamong the 88 specimens submitted. The overall rate of diagnosis was 6.05 cases per 1000 students during the 9-month...References1. MURRAY B. Campylobacter enteritis [Letter]. Ann Intern Med. 1983;98:1029-30. LinkGoogle Scholar2. WALDER M. Epidemiology of Campylobacter enteritis. Scand J Infect Dis. 1982;14:27-33. CrossrefMedlineGoogle Scholar3. KENDALLTANNER EE. Campylobacter enteritis in general practice. J Hyg (London). 1982;88:155-63. CrossrefMedlineGoogle Scholar4. BUTZLERSKIRROW JM. Campylobacter enteritis. Clin Gastroenterol. 1979;8:737-65. CrossrefMedlineGoogle Scholar5. BLASERRELLER ML. Campylobacter enteritis. N Eng J Med. 1982;305:1444-52. CrossrefGoogle Scholar6. BLASERWELLSFELDMANPOLLARDALLEN MJRRJ AND THE COLLABORATIVE DIARRHEAL DISEASE STUDY GROUP. Campylobacter enteritis in the United States. Ann Intern Med. 1983;98:360-5. LinkGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Emory University Student Health Services, Emory University School of Medicine Atlanta, GA 30322 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByA demographic survey of campylobacter, salmonella and shigella infections in England: A Public Health Laboratory Service SurveyCampylobacter Enteritis in College Students 1 April 1984Volume 100, Issue 4Page: 615-615KeywordsCampylobacterCampylobacter jejuniEnteritisMedical servicesResearch laboratories Issue Published: 1 April 1984 PDF DownloadLoading ...
Combined D‐dimer and clinical probability are useful for exclusion of recurrent deep venous thrombosis
Authors: Carlos Aguilar, Valentin del Villar
Journal: American Journal of Hematology (2006)

Abstract It is estimated that up to one‐third of patients with a history of deep venous thrombosis (DVT) present with symptoms of recurrent DVT. Our objective was to investigate both the diagnostic value of D‐dimer (DD) and safety of a standard diagnostic algorithm including clinical assessment, plasma DD levels, and compression venous ultrasound as diagnostic tools in outpatients presenting with clinically suspected acute recurrent DVT of the lower limbs. We have enrolled 105 outpatients with a previous history of confirmed DVT and clinically suspected recurrent DVT. A 3‐month follow‐up period was carried out for patients in whom DVT was initially excluded. Prevalence of DVT in our study population was 44.8% (47/105). DD was negative in 17.1% of cases (18/105) and DVT could be ruled out in 15.2% of patients evaluated (16/105) on the basis of an unlikely clinical probability and a negative DD result. Only one false negative DD result in a patient scored as likely for DVT was found. Sensitivity, specificity, positive and negative predictive value of DD for the diagnosis of DVT were 97.9% (95% CI 88.9–99.6%), 29.3% (95% CI 19.2–42.0%), 52.9% (95% CI 42.5–63.0) and 94.4% (95% CI 74.2%–99.0), respectively. Sensitivity was 100% (95% CI 75.7–100) in the group of patients in whom DVT was considered unlikely. A diagnostic strategy combining clinical evaluation and DD has proved to be useful for the exclusion of DVT in subjects with clinically suspected recurrent DVT, especially in patients included in the lower clinical pretest probability group. Am. J. Hematol., 2006. © 2006 Wiley‐Liss, Inc.
Abstract 3482: A robust TALENs system for highly efficient mammalian genome editing
Authors: Siliang Zhang, Yuanxi Feng, Xin Huang
Journal: Cancer Research (2014)

Abstract Recently, transcription activator-like effector nucleases (TALENs) have emerged as a highly effective tool for genomic editing. A pair of TALENs binds to two DNA recognition sites separated by a spacer sequence, and the dimerized FokI nucleases at the C terminal then cleave DNA in the spacer. Because of its modular design and capacity to precisely target almost any desired genomic locus, TALENs is a technology that can revolutionize the entire biomedical research field. Currently, for genomic editing in cultured cells, two plasmids encoding a pair of TALENs are co-transfected, followed by limited dilution to isolate cell colonies with the intended genomic manipulation. However, uncertain transfection efficiency becomes a bottleneck, especially in hard-to-transfect cells, reducing the overall efficiency of genome editing. We have developed a robust TALENs system in which each TALEN plasmid also encodes a fluorescence protein. Thus, cells transfected with both TALEN plasmids, a prerequisite for genomic editing, can be isolated by fluorescence-activated cell sorting. Our improved TALENs system can be applied to all cultured cells to achieve highly efficient genomic editing. Furthermore, an optimized procedure for genomic editing using TALENs is also presented. We expect our system to be widely adapted by the scientific community. Citation Format: Siliang Zhang, Yuanxi Feng, Xin Huang. A robust TALENs system for highly efficient mammalian genome editing. [abstract]. In: Proceedings of the 105th Annual Meeting of the American Association for Cancer Research; 2014 Apr 5-9; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2014;74(19 Suppl):Abstract nr 3482. doi:10.1158/1538-7445.AM2014-3482
Availability of cadaveric kidneys.
Authors: R A Sells, M R Heal
Journal: BMJ (1972)

benefit from this type of arrangement.Certainly there is present need to initiate controlled trials to measure the hospital effect on coronary patients.The only other data available,' on an in-hospital but non- randomized trial, indicate that the early re- duction of mortality in the coronary care unit is not sustained over time.It is for these reasons that we have sought professional criticism directed at the specifics of Dr. Mather's trial and with particular reference to any evidence of bias and selection beyond that clearly stated in the pre- liminary report.We have been unable to find any grounds for invalidation of the technique of this study.-I am, etc.,
Post-traumatic stress disorder in the context of terrorism and other civil conflict in Northern Ireland: randomised controlled trial
Authors: Michael Duffy, Kate Gillespie, David M Clark
Journal: BMJ (2007)

<b>Objective</b> To evaluate the effectiveness of cognitive therapy for post-traumatic stress disorder related to terrorism and other civil conflict in Northern Ireland. <b>Design</b> Randomised controlled trial. <b>Setting</b> Community treatment centre, Northern Ireland. <b>Participants</b> 58 consecutive patients with chronic post-traumatic stress disorder (median 5.2 years, range 3 months to 32 years) mostly resulting from multiple traumas linked to terrorism and other civil conflict. <b>Interventions</b> Immediate cognitive therapy compared with a waiting list control condition for 12 weeks followed by treatment. Treatment comprised a mean of 5.9 sessions during 12 weeks and 2.0 sessions thereafter. <b>Main outcome measures</b> Primary outcome measures were patients9 scores for post-traumatic stress disorder (post-traumatic stress diagnostic scale) and depression (Beck depression inventory). The secondary outcome measure was scores for occupational and social functioning (work related disability, social disability, and family related disability) on the Sheehan disability scale. <b>Results</b> At 12 weeks after randomisation, immediate cognitive therapy was associated with significantly greater improvement than the waiting list control group in the symptoms of post-traumatic stress disorder (mean difference 9.6, 95% confidence interval 3.6 to 15.6), depression (mean difference 10.1, 4.8 to 15.3), and self reported occupational and social functioning (mean difference 1.3, 0.3 to 2.5). Effect sizes from before to after treatment were large: post-traumatic stress disorder 1.25, depression 1.05, and occupational and social functioning 1.17. No change was observed in the control group. <b>Conclusion</b> Cognitive therapy is an effective treatment for post-traumatic stress disorder related to terrorism and other civil conflict. <b>Trial registration</b> Current Controlled Trials ISRCTN16228473.
Interferon in acute and subacute encephalitis
Authors: P Lebon, B Boutin, O Dulac, G Ponsot, M Arthuis
Journal: BMJ (1988)

Intrathecal synthesis of interferon γ was shown in 14 out of 16 samples of cerebrospinal fluid collected in the first days of disease in adults, children, and newborn infants with herpes encephalitis. This synthesis was concomitant with that of interferon α and was switched off when the specific antibodies in the central nervous system increased. No endogenous interferon γ was detected in 11 serum samples or 13 samples of cerebrospinal fluid collected early in the course of the disease from patients with measles encephalitis and rubella encephalitis, or in serum and cerebrospinal fluid samples from seven patients with subacute sclerosing panencephalitis. In serum collected after the 10th day after the onset of neurological symptoms interferon γ was present at low concentrations in only three out of 11 serum specimens from patients with measles encephalitis or rubella encephalitis. Interferon γ was present in patients with acute herpes encephalitis and there was active virus replication, but it was not present in postinfectious encephalitis. Possibly the local production of specific antibodies masks the viral antigens and switches off the induction of interferons.
326 Early pharmacokinetics, pharmacodynamics and hepatitis C viral kinetics on treatment with pegylated interferon (IFN) alfa-2A with or without ribavirin: Characterization of the null responder
Authors: A DIBISCEGLIE, P OSMACK, J HOFFMAN, J STRINKO
Journal: Hepatology (2003)

EPIC-3 is a prospective, international study that has demonstrated the efficacy of PEG-IFN alfa-2b plus weight-based ribavirin in patients with chronic hepatitis C and significant fibrosis who previously failed any interferon–alfa/ribavirin therapy. The aim of the present study was to assess FibroTest (FT), a validated non-invasive marker of fibrosis in treatment-naive patients, as a possible alternative to biopsy as the baseline predictor of subsequent early virologic (EVR) and sustained virologic response (SVR) in previously treated patients.Of 2312 patients enrolled, 1459 had an available baseline FT, biopsy, and complete data. Uni- (UV) and multi-variable (MV) analyses were performed using FT and biopsy.Baseline characteristics were similar as in the overall population; METAVIR stage: 28% F2, 29% F3, and 43% F4, previous relapsers 29%, previous PEG-IFN regimen 41%, high baseline viral load (BVL) 64%. 506 patients (35%) had undetectable HCV-RNA at TW12 (TW12neg), with 58% achieving SVR. The accuracy of FT was similar to that in naive patients: AUROC curve for the diagnosis of F4 vs F2 = 0.80 (p <0.00001). Five baseline factors were associated (p <0.001) with SVR in UV and MV analyses (odds ratio: UV/MV): fibrosis stage estimated using FT (4.5/5.9) or biopsy (1.5/1.6), genotype 2/3 (4.5/5.1), BVL (1.5/1.3), prior relapse (1.6/1.6), previous treatment with non-PEG-IFN (2.6/2.0). These same factors were associated (p ⩽0.001) with EVR. Among patients TW12neg, two independent factors remained highly predictive of SVR by MV analysis (p ⩽0.001): genotype 2/3 (odds ratio = 2.9), fibrosis estimated with FT (4.3) or by biopsy (1.5).FibroTest at baseline is a possible non-invasive alternative to biopsy for the prediction of EVR at 12 weeks and SVR, in patients with previous failures and advanced fibrosis, retreated with PEG-IFN alfa-2b and ribavirin.
Radioactive Phosphorus (P32) in Treatment of Menorrhagia
Authors: H. C. McLaren, J. C. Heath, A. Quinton
Journal: BMJ (1953)

and Conclusions The results of 200 anastomotic operations in patients with morbus caeruleus are described, nearly all of them having been followed for more than a year and several for four years.Most had Fallot's tetralogy, and here the results were excellent.Many were seriously ill, but only 8% died and 75% benefited greatly, so that they can walk a mile or more and lead lives that are almost normal without too much physical activity.In the smaller number of more complex lesions, such as tri- cuspid atresia, dextrocardia, and pulmonary atresia, the results were much less good.The total mortality was nearly 30%, and only 35% obtained the good results.More experience is needed to decide which of these patients can hope to benefit from operation, but some tentative suggestions are made.Most patients have an increased capacity and lose much of their cyanosis, clubbing, and polycythaemia.Some cyanosis, at least on exercise, and some clubbing generally remain unless they were very slight.The haemoglobin usually falls from between 120 and 160% to between 90 and 120%.In nearly all the successful cases a continuous murmur can be heard at the site of the anastomosis, and the presence of this soon after the operation is often one of the best indications of success.The pulse pressure may be a little wider as the result of the anastomosis, but not often much wider.Generally the improvement gained in the first few months after operation is a good guide to the future and is maintained.The annual mortality rate is not much above 1%, and this includes the risks to which these patients are inevitably exposed whether they have an operation or not.Special attention has been paid to the increase in the size of the heart because this has been thought to be the great drawback to the operation.Generally the increase is not great, and is not progressive after the first few months.The cardiothoracic ratio may increase quickly from 48 to 52% and then remain constant during the period of observation.A few patients in whom the in- crease is great or even progressive make us anxious lest they may develop congestive heart failure, but except for three with complex lesions in whom this happened within the first six to nine months no others have yet done so.It is a pleasure to express our thanks to the surgeons who have made this work possible: Mr. R. C. Brock, who has operated on the largest number,
Functional Fecal Retention Visualized by 111In-DTPA Colon Transit Scintigraphy
Authors: Jose Rafael Infante, Juan I. Rayo, Justo Serrano, Maria L. Dominguez, Lucia Garcia, Manuel Moreno
Journal: Clinical Nuclear Medicine (2015)

Constipation is an extremely common problem in children, varying from mild and short-lived to severe and chronic. Chronic constipation is a serious childhood condition and requires further investigation, including blood test, colonoscopy, radio-opaque marker study, and/or scintigraphy. We present small bowel and colon transit scintigraphy of a 14-year-old girl with history of chronic constipation, abdominal pain, weight loss, and poor response to medical treatment. After oral administration of In-DTPA in water, planar and SPECT/CT images showed normal small bowel transit time and functional fecal retention in colon transit study.
Dilatation of the Pulmonary Artery in Pulmonary Stenosis
Authors: F. S. P. VAN BUCHEM
Journal: Circulation (1956)

Dilatation of the pulmonary artery occurs frequently in cases of valvular pulmonary stenosis and is often called "poststenotic." We determined the diameter of the pulmonary artery angiocardiographically and compared this with the data obtained by heart catheterization in cases of pulmonary stenosis and of idiopathic dilatation of the pulmonary artery. Features are presented which constitute arguments in favor of Laubry's suggestion that we are dealing with two different abnormalities, namely, a valvular stenosis and a dilatation of the pulmonary artery though hydraulic forces may contribute to the final development of the dilatation.
Can the PSRO's Be Cost Effective?
Authors: Anita Fulchiero, Steven Miller, Cornelius R. Foley, H. Thomas Ballantine, Charles S. Amorosino
Journal: New England Journal of Medicine (1978)

Abstract To analyze the effect of the Common wealth Health Agencies Monitoring Program on the length of stay of a sample of Massachusetts Medicaid patients, we compared their experience with that of non-Medicaid patients. We found a consistently decreasing trend in the length of stay of Medicaid patients during the 2 1/2-year period studied. The average length of stay of Medicaid patients decreased by 11.9 per cent relative to the norm, whereas the non-Medicaid length of stay decreased by only 6.6 per cent. We infer that the Program may be credited with the 5.3 per cent differential decrease. The consistency and reliability of the data suggest that similar results may be extrapolated to the hospitals not sampled. We conclude that Professional Standards Review Organizations, of which this program was a precursor, can be cost effective, given an expanded review mandate and the application of suitable evaluative processes. (N Engl J Med 299:574–580, 1978)
US Launches Undiagnosed Diseases Program
Authors: Bridget M. Kuehn
Journal: JAMA (2008)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Sickle Cell Trait in The White Population
Authors: C. J. McGrew
Journal: JAMA (1973)

<h3>To the Editor.—</h3> In the April 30 issue,The Journaldeals with an article regarding sickle cell trait in the white population (224:605, 1973). For more than a year the Navy has been testing recruits for sickle cell trait and glucose-6-phosphate dehydrogenase deficiency in order to determine their qualification for various programs. The article says "within the indigenous populations of the western hemisphere, the sickle cell trait is virtually absent unless there is obvious Negro admixture." While this statement has been made, it does not represent the true picture based on our brief experience in screening recruits at the Orlando Naval Training Center. In one group of over 14,000 recruits tested at another training center, the incidence of sickle cell trait in the white population was.08%. For the past three months at our center, we have screened about 5,000 recruits and have paid specific attention to the background of those
Interleukin-10 in the intestine
Authors: STEFAN SCHREIBER
Journal: Gut (1997)

See article on page215 

Cytokines are small glycoprotein mediators involved in communication between cells. Immunological responses are, to a high degree, regulated and directed by specific cytokines. The simultaneous action of different cytokines, as well as their sequential interaction with target cells, seems to be of pivotal importance for an efficient host defence reaction. In inflammation, pro-inflammatory cytokines (that is, tumour necrosis factor-α (TNF-α), interleukin (IL)-1, IL-8, and IL-12) which initiate and perpetuate the activation of immune and non-immune cells are counterbalanced by contra-inflammatory mediators. According to this scheme, human T helper cells have also been functionally divided into those producing cytokines which augment immune activation (IL-2 and interferon-γ, which are attributed to type 1 T helper cells) and those secreting immunoregulatory interleukins (IL-4, IL-5, IL-10, and IL-13 by type 2 T helper cells).

Interleukin 10, previously named cytokine synthesis inhibitory factor (CSIF), has, like many other cytokines, multiple biological effects. Its main immunoregulatory function seems to be the inhibition of effector functions of activated phagocytes (monocytes, macrophages, granulocytes), T cells and non-immune cells. Human IL-10 down regulates transcription and secretion of IL-1β, IL-6, IL-8, TNF-α, and G-CSF by activated monocytes and macro- phages.1 …
Diagnosis of Depression in the 1980s
Authors: Mark S. Gold
Journal: JAMA (1981)

DEPRESSION is the most common of psychiatric symptoms and occurs in many psychiatric illnesses. Major depressive disorder can be distinguished by sleep and appetite disturbances and other "hypothalamic" signs and symptoms.<sup>1-4</sup>Major depression can be subdivided into unipolar and bipolar depressive illness on the basis of a history of mania in bipolar illness (Fig 1), and into primary and secondary depression.<sup>1-4</sup>Secondary depression and minor depressive illness occur in medical illness and in nonaffective psychiatric illness such as obsessive-compulsive neurosis, personality disorders, schizophrenia, drug and alcohol dependence, and sexual dysfunction, respectively. These categories (Fig 1) have been helpful in improving diagnostic reliability between psychiatrists and reducing heterogeneity in diagnostic groups. They improve understanding of pathophysiology and facilitate prediction of treatment response and prognosis. Biologic tests have been developed that can support a clinical impression or diagnosis. A number of important biochemical subgroups of unipolar major depression can be
TEMPORAL CHANGES IN LEFT VENTRICULAR STRAIN VIS-À-VIS EJECTION FRACTION IN PATIENTS WITH TAKOTSUBO CARDIOMYOPATHY
Authors: Mandeep S. Randhawa, Ashwat Dhillon, Zoran Popovic, Venu Menon, Brian Griffin, Milind Desai
Journal: Journal of the American College of Cardiology (2014)
Surgical Treatment of Narrowing of the Internal Carotid Artery
Authors: C. H. Edwards, N. S. Gordon
Journal: BMJ (1962)

Thank you for your interest in spreading the word about The BMJ.NOTE: We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail. We do not capture any email address. Username * Your Email * Send To * You are going to email the following Surgical Treatment of Narrowing of the Internal Carotid Artery Your Personal Message CAPTCHA This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.