tbuckley/cabot-search huggingface dataset:
Abstract 3414: EMT-associated genes are altered in giant cell tumor of bone
Authors: Paula Rahal, Erica Babeto, Marilia de Freitas Calmon, Andre Conceição, Débora Zuccari
Journal: Cancer Research (2011)

Abstract The giant cell tumor of bone (GCT) is a benign bone-destructive neoplasm, with uncertain biological behavior, with features such as a large number of multinucleated giant cells and aggressive behavior. The local recurrence of GCT is often observed, especially in the first three years after treatment, giving a rate of recurrence ranging from 20% to 50% of cases. Further aggravating the recurrence, is the fact that after a relapse, patients often also presents metastasis in other organs, mainly in the lungs. In this study we investigate the expressions of epithelial and mesenchymal (EMT) markers (ADAM23, CDH1, CDH3, MMP14, p16, TIMP2 and VIM) in GCTs by quantitative qPCR. The expression of the MMP14, TIMP2 and VIM genes increased in more than 96% samples and ADAM23, CDH1, CDH3 and p16 genes had expression reduced in more than 91% of GCTs samples. Since ADAM23, CDH1, CDH3 and p16 have CpG islands in their promoter regions and low expression in tumor tissue, their methylation patterns were analyzed by MSP-PCR. For ADAM23 and p16 genes were detected a high frequency of hypermethylation. The lower expression of ADAM23 and p16 are directly related to the recurrence and metastasis in GCTs. The genes MMP14, TIMP2 and VIM are related to angiogenesis, degradation of extracellular matrix and cell migration and presented with increased expression in GCT, also confirmed by immunohistochemistry. These observations suggest that dysregulation of these genes may be a key factor responsible for the initiation and perpetuation of EMT in GCT, leading to cellular migration and malignant transformation, contributing to development of metastases and tumor progression. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 102nd Annual Meeting of the American Association for Cancer Research; 2011 Apr 2-6; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2011;71(8 Suppl):Abstract nr 3414. doi:10.1158/1538-7445.AM2011-3414
Pathology of the Lung (Excluding Pulmonary Tuberculosis)
Authors: Milton G. Bohrod
Journal: JAMA (1969)

In the six years since its first appearance, Spencer's book has become a standard text and important reference. Well-written and well-arranged, it has taken its place among the best of the numerous good books of our generation. Now it appears in a new and enhanced edition, with 250 more pages, 25% more than the first edition. Slightly smaller type allows more words per page without decreasing the legibility. Many illustrations have been added, and the bibliography brought up to date. The normal anatomy and histology of the lung has been expanded at all levels from gross pathology to electron microscopy. Chemical and physiologic considerations are not segregated in introductory chapters but receive attention wherever they are of importance. Illustrations, almost entirely black and white, are clear and require only a minimum of explanatory legend. The illustrations of whole-lung mounts are especially good; the technique for making them, as well as
CD36 and CD14 immunoreactivity of Reiter cells in inflammatory synovial fluids
Authors: E. SELVI
Journal: Annals of the Rheumatic Diseases (2000)

Reiter cells are macrophages containing ingested polymorph nuclei that are commonly found in most inflammatory synovial fluids. Available data indicate that CD36 and CD14 on human monocyte derived macrophages are adhesion molecules involved in several biological processes.1 Of interest, their role in the process of adhesion and phagocytosis of apoptotic cells has been recently demonstrated.2-5 

Jones and colleagues demonstrated reduced Reiter cells in the synovial fluids from patients with rheumatoid arthritis. This observation is consistent with the hypothesis that Reiter cells play a regulatory part in preventing autolysis of polymorphonuclear neutrophils (PMN) and thus local tissue damage.6 

The purpose of this study was to evaluate by histochemical technique whether Reiter cells express CD36 and CD14 in inflammatory synovial fluids.

We analysed the synovial fluids obtained from the knee joints of 10 patients suffering from inflammatory joint diseases of recent onset (< 6 weeks). Three patients had seropositive active rheumatoid arthritis, four patients had seronegative spondyloarthritis (two reactive arthritis, one psoriatic arthritis, one enteroarthritis) and three patients had …
Universal coverage of renal dialysis in Thailand: promise, progress, and prospects
Authors: S. Tantivess, P. Werayingyong, P. Chuengsaman, Y. Teerawattananon
Journal: BMJ (2013)

Thailand's experience in introducing renal replacement therapy as part of its universal health coverage scheme shows the importance of evidence and stakeholders' active participation in all phases of policy development, say <b>Sripen Tantivess and colleagues</b>
Chlorhexidine-Impregnated Sponges and Prevention of Catheter-Related Infections
Authors: Yong-Gang Lv
Journal: JAMA (2009)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Journals JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Robert Patrick Hickey
Authors: A V Fisher
Journal: BMJ (2003)

Former consultant in physical medicine and rheumatology Medway Group of Hospitals (b 1922; q London 1945; DPhysMed, MC), d 4 September 2002.​2002.




Figure 1




Bob spent four years in the Royal Army Medical Corps before becoming a registrar in chest medicine. Almost immediately he was recalled to the Gloucestershire regiment in Korea. In April 1951 at the Imjin river battle he remained with the wounded and was a prisoner of war of the Chinese for three years. He was a registrar in physical medicine at St Thomas's and a senior registrar at the Royal Free before becoming a consultant at the Medway Hospitals. He leaves a wife, Heather, and two sons.
Rapid-Test Sensitivity for Novel Swine-Origin Influenza A (H1N1) Virus in Humans
Authors: Christopher C. Blyth, Jonathan R. Iredell, Dominic E. Dwyer
Journal: New England Journal of Medicine (2009)

To the Editor: Faix et al. (Aug. 13 issue)1 highlight the moderate sensitivity of rapid antigen tests as compared with reverse-transcriptase–polymerase-chain-reaction (RT-PCR) assays in detecting the 2009 pandemic influenza A (H1N1) virus in infected patients. We found that the antigen tests had poor sensitivity to the virus when used in a subgroup of 21 patients in the Australian intensive care cohort with severe 2009 influenza A (H1N1) virus infection and acute lung injury that required mechanical ventilation.2 In these patients, rapid antigen tests (QuickVue A+B, Quidel) were performed on swabs from the nose and throat, and influenza type-specific immunofluorescent antigen . . .
When to Refer to the Geneticist
Authors: Theodore Kushnick
Journal: JAMA (1976)

WITH THE recent dramatic advances in medical genetics and the increased interest in genetic counseling, most physicians have lost sight of the fact that they have been involved with genetic evaluations in the private practice of medicine for many years. Essentially, all human beings have normal physical characteristics that have been developed as the result of the interaction between small contributions by multiple genes and the environment. These multiplegene or polygenic multifactorial inheritance patterns have always been noted by lay persons as well as physicians. Both groups expect short parents to produce short children and large parents to produce large children. We expect obese individuals to have family histories of obesity. Characteristics such as height, weight, head circumference, lean body mass, intelligence, and age of sexual maturation represent this polygenic endowment interacting with one's environment. The standards that we physicians use for normalcy are derived from studies of groups of
Predictors of Specific Airway Resistance during Childhood
Authors: Debra A. Stern, Nipasiri Voraphani, Wayne J. Morgan
Journal: American Journal of Respiratory and Critical Care Medicine (2014)

effects of pollution on the RV at a population level represents a milestone.As minimally invasive measures of RV function and structure become more widely available, we look forward to an increased understanding of RV responses to air pollution exposure.Such advances have significant public health relevance and the potential to further our understanding of the complex interplay between the lungs and the right and left heart in the face of pollution exposure.
Abstract 4393: ASG-5ME is a novel antibody drug conjugate (ADC) for treating prostate cancers
Authors: Jean M. Gudas, Zili An, Robert Kendall Morrison, Karen J. Morrison, Xiao-Chi Jia, Arthur B. Raitano, Steven Duniho, Leia Smith, Dawn Hayes, Peter Senter, Dennis Benjamin, Aya Jakobovits
Journal: Cancer Research (2010)

Abstract AGS-5 is a novel transmembrane antigen discovered by Agensys using transcriptional profiling that is highly expressed in a variety of epithelial tumors. A fully human IgG2k monoclonal antibody that binds to AGS-5 with high affinity was conjugated with the anti-microtubulin drug, monomethyl auristatin E (MMAE), via a conditionally labile valine-citrulline (vc) maleimidocaproyl linker to yield an average drug: antibody ratio of 3.7. Following cell surface binding, ASG-5ME is internalized and trafficked through the endocytic pathway, where proteolytic cleavage releases free active drug that subsequently binds and disrupts microtubules. We evaluated the expression of AGS-5 protein in a large number of prostate patient tumors using IHC. ASG-5ME was evaluated for its cell cytoxicity in vitro, and its anti-tumor activity was investigated on different established xenograft tumors, using both patient-derived and cell line models of prostate cancer. The pharmacokinetics of ASG-5ME in mice was also evaluated. Our studies indicated AGS-5 protein was expressed in more than 95% of primary prostate cancer specimens and distant metastases, and on more than 90% and 80% of pancreatic and gastric cancer specimens, respectively. ASG-5ME, bound with high affinity (Kd = 0.5 nM) to both human and cynomolgus monkey AGS-5 and mediated potent dose dependent cell cytotoxicity in vitro. ASG-5ME showed significant long term tumor regression and eradication of multiple established prostate cancer xenografts, including those grown orthotopically. Phamacokinetic (PK) analysis of ASG-5ME in mice indicated that the ADC was stabile with long T1/2 of ∼12 days. When considered together these data indicate that ASG-5ME is a promising therapeutic ADC for the treatment of prostate and other AGS-5 expressing cancers. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 101st Annual Meeting of the American Association for Cancer Research; 2010 Apr 17-21; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2010;70(8 Suppl):Abstract nr 4393.
Cochlear dysfunction in type 2 diabetes: A complication independent of neuropathy and acute hyperglycemia
Authors: Ferdinanco Carlo Sasso, Teresa Salvatore, Gaetano Tranchino, Domenico Cozzolino, Arturo Armone Caruso, Marcello Persico, Sandro Gentile, Daniele Torella, Roberto Torella
Journal: Metabolism (1999)
958 SUPER-PARAMAGNETIC IRON OXIDE-MRI: A NOVEL TECHNIQUE IN EXPERIMENTAL LIVER STUDIES SHOWS DEFECTIVE KUPFFER CELL PHAGOCYTIC FUNCTION IN HUMAN NON ALCOHOLIC FATTY LIVER DISEASE
Authors: M. Ono, K. Kubota, A. Hirose, Y. Nozaki, M. Takahashi, S. Iwasaki, T. Saibara, Y. Ogawa, S. Onishi, J.A. Oben
Journal: Journal of Hepatology (2008)
Pentazocine-Induced Fibrous Myopathy
Authors: David Fleiss
Journal: JAMA (1975)

<h3>To the Editor.—</h3> A 59-year-old man, addicted to intramuscular injections of pentazocine for at least four years, was recently admitted to the Neurological Institute of New York with marked induration of the deltoid, gluteus maximus, quadriceps, and gastrocnemius muscles bilaterally. As reported by Oh et al (231:271, 1975), "the considerable limitation of motion due to the fibrotic muscle contracture, and the minimal weakness of involved muscles" typifies pentazocine myopathy, and this was true of him. His problem was sclerosis, not spasm or weakness. Both his muscle enzyme content and collagen vascular test results were normal. The diagnosis of pentazocine-induced myopathy was suggested when the performance of an otherwise unremarkable electromyogram was hindered in the affected muscles by an extensive fibrosis that made needle placement difficult. This case is of particular interest for two reasons: (1) a muscle biopsy specimen of the thoracic paraspinal area showed the same extreme fibrosis as
Astrocytoma Following the Pyramidal Tract
Authors: A Spuler, J L Atkinson
Journal: New England Journal of Medicine (2000)

Figure 1. A 57-year-old man presented with a moderate left-sided hemiparesis. T1-weighted magnetic resonance images with gadolinium revealed a contrast-enhanced lesion in the internal capsule and the adjacent basal ganglia. Stereotactic biopsy revealed the tumor to be a high-grade astrocytoma. Consecutive axial T2-weighted magnetic resonance images demonstrate the tumor (pair of arrowheads in Panel B) in the internal capsule and the adjacent basal ganglia. In addition, a hyperintense signal shows that the pyramidal tract was affected from the pons to the corona radiata (single arrowheads in Panels A, C, and D). Because isolated malignant cells occur . . .
Prevalence of Antibodies to EB Virus and Other Herpesviruses
Authors: David D. Porter
Journal: JAMA (1969)

Serum samples from 224 children of low socioeconomic status and from 281 children and 120 young adults of high socioeconomic status were evaluated for immunofluorescent antibodies to EB virus and for complement-fixing antibodies to herpes simplex virus and to cytomegalovirus. Regardless of socioeconomic status, approximately 45% of children 7 to 24 months of age were found to have antibody to EB virus, and by 4 to 7 years of age, the percentage of children with antibody approximated that of 73% to 90% found in the adults. Children of a low socioeconomic status had a slightly higher prevalence of EB antibody, and a markedly higher prevalence of herpes simplex antibody, than those of a high socioeconomic status. This study indicates that infection with EB virus occurs much earlier and more commonly in children than infections with herpes simplex virus and cytomegalovirus do.
Treatment of Photosensitive American Indians With Oral Beta Carotene
Authors: Ramon M. Fusaro
Journal: JAMA (1980)

<h3>To the Editor.—</h3> A hereditary form of polymorphous light eruption affects Indians from the central plains of Canada and the United States<sup>1</sup>to Central and South America.<sup>2</sup>Exposure to sunlight leads to pruritic macular, papular, and vesicular eruptions, sometimes with pyoderma and scarring. Symptoms appear in early spring in those in the northern hemisphere and persist until late fall. Patients are sensitive to long exposure to ultraviolet radiation (symptoms appear after exposure through window glass) and therefore receive no protection from commercial sunscreens. The clinical aspects and seasonal appearance of symptoms are reminiscent of erythropoietic protoporphyria (EPP), but neither we nor Birt and Davis<sup>1</sup>have detected elevated porphyrin levels in patients. Oral beta carotene is recommended for photoprotection of persons with EPP (Solatene package insert, Roche Laboratories, 1975). We reasoned that, since the disorder affecting American Indians resembles EPP, oral beta carotene may also protect these persons.
769-5 Reduction of Silent Myocardial Ischemia by Pravastatin Additional to the Conventional Treatment of Patients with Angina Pectoris
Authors: Ad J. van Boven, J. Wouter Jukema, Aeilko H. Zwinderman, Kong I. Lie, Albert V.G. Bruschke
Journal: Journal of the American College of Cardiology (1995)
Non-compliance with oral chemotherapy in childhood leukaemia
Authors: J S Lilleyman, L Lennard
Journal: BMJ (1996)

as infections, infestations, or other factors related to bird keeping in different countries.Another potential explanation for the discrepancy is that neither of the two new studies has looked specifically at pigeon keeping, which was the only significant association with lung cancer in the study from Scotland.5In Britain at least there is likely to be a substantial difference in the number ofbirds kept, and consequent degree of exposure, between those keeping pigeons for racing and those who keep one or two birds as indoor domestic pets.It is perhaps still possible that the previously reported associations relate to an underlying effect that is specific to pigeon keeping.To resolve these uncertainties it would be necessary to repeat these studies yet again in the populations that gave rise to the original observations of an association, taking particular care to deal with confounding effects.However, these two new studies seem to be conclusive in two respects.First, they
Controlled trial of Iodosorb in chronic venous ulcers.
Authors: M C Ormiston, M T Seymour, G E Venn, R I Cohen, J A Fox
Journal: BMJ (1985)

Cadexomer iodine (Iodosorb) is a hydrophilic starch powder containing iodine, which is a suitable dressing for granulating wounds such as venous ulcers. A total of 61 outpatients with chronic venous ulcers participated in a randomised optional crossover trial using cadexomer iodine or a standard dressing for their ulcers. The trial lasted for 24 weeks or until the ulcer had healed. Two patients withdrew during the course of the trial. Both treatments were highly effective, but the epithelium of ulcers dressed with cadexomer iodine grew again significantly faster (p less than 0.001). At the midpoint of the trial (12th week) 13 of 30 patients receiving standard treatment were changed to cadexomer iodine, while only three of 29 receiving cadexomer iodine changed to the standard dressing (p less than 0.02). In most cases ulcers were dressed and rebandaged daily by the patients themselves after instruction and supervision. This may be better than having dressings and bandages applied by professionals less regularly.
STUDIES IN PHOSPHORUS METABOLISM IN MAN. III. THE DISTRIBUTION, EXCHANGE AND EXCRETION OF PHOSPHORUS IN MAN USING RADIOACTIVE PHOSPHORUS (P32) AS A TRACER 1
Authors: Stanley M. Levenson, Margaret A. Adams, Hyman Rosen, F. H. Laskey Taylor
Journal: Journal of Clinical Investigation (1953)

200 pc P), in the form of Na.HP0S5 (carrier-free) dissolved in about 3 ml. of pyrogen-free water, was in- jected intravenously in a few seconds into an antecubital vein.Blood samples were thereafter collected serially from the opposite arm.The blood was collected in bot- tles containing dried potassium-ammonium oxalate ad- 1 This work was aided in part, by gifts from Smith,
John Keeling Roberts
Authors: Christopher Keeling Roberts
Journal: BMJ (2004)

Former general practitioner Wem, Shropshire (b 1916; q Westminster Medical School 1941), d 17 February 2004.​2004.




Figure 1




After house jobs and a period as a junior surgeon, he entered a partnership in general practice in Wem, north Shropshire, in 1946. His real love was midwifery. Home deliveries were the rule rather than the exception and, with the relative scarcity of midwives or district nurses, John delivered more than 2000 babies. He was president of the Shropshire branch of the BMA in 1953 and chairman of the Salop Medical Committee from 1974 to 1984, and played an active part in local government, being responsible for a large building programme that significantly improved housing in Wem. He leaves a wife, Margaret, and three children.
Physiological Significance of Maximal Oxygen Intake in "Pure" Mitral Stenosis
Authors: JOHN R. BLACKMON, LORING B. ROWELL, J. WARD KENNEDY, RICHARD D. TWISS, ROBERT D. CONN
Journal: Circulation (1967)

Acute circulatory and respiratory adjustments to mild through maximal upright exercise were studied in seven patients with "pure" mitral stenosis. Maximal oxygen uptake was determined objectively by demonstrating a plateau of oxygen uptake with increasing workloads. Time to reach a plateau of oxygen uptake was normal (2 to 3 minutes) at all workloads. At any given oxygen uptake, cardiac output and hepatic clearance of indocyanine green (ICG) were abnormally low while total arteriovenous (A-V) oxygen difference, heart rate, blood lactate, and ventilation were abnormally high. However, with respect to relative oxygen uptake (per cent of maximal oxygen uptake), the reduction in cardiac output was exaggerated, but A-V oxygen difference, heart rate, blood lactate, and hepatic clearance of ICG were essentially normal. RQ and V E /V O O2 were quantitatively abnormal even with respect to relative oxygen uptake, but the pattern of changes from mild to maximal exercise was normal. Low maximal oxygen uptake defined the reduction in stroke volume while other circulatory responses were normal with respect to relative oxygen uptake.
Abstract A25: Variations of human papillomavirus type 16 in cervical, lung, and skin cancers in Sichuan, China
Authors: Jian Zhang, Tao Wang, Min Han, Zhihui Yang, Min Zhang, Lunxu Liu, Bin Zhou, Yue Chen, Qiannan Hou, Yanyun Wang, Ting Lai, Lin Zhang, Huaizhong Hu, Mingrong Xi
Journal: Clinical Cancer Research (2010)

Abstract Human papillomavirus (HPV) is closely related with many kinds of cancers such as cervical, lung, and skin cancers, etc. HPV 16 showed intratypic variations that were known to differ in oncogenic potential and geographic distribution. This study was designed to analyze sequence variants in oncogenes E6, E7 and L1 of HPV 16 in cervical, lung, and skin cancers in Sichuan, China. Materials from 138 non-malignant controls, 122 cervical cancer patients, 104 lung cancer patients and 104 skin cancer patients were analyzed by PCR and direct sequencing. The infection rates of HPV 16 in cervical, lung, skin cancers were respectively 68.9%, 17.3%, 5.8%. The Asian prototype was the most prevalent variant in cervical cancer in Sichuan (40%). Compared with that detected in cervical cancer, lung and skin cancers showed more monotonous variations, but several mutations on L1 genes existed only in lung or skin cancers such as G6818C, C7011A, and C7017A. Citation Information: Clin Cancer Res 2010;16(14 Suppl):A25.