tbuckley/cabot-search huggingface dataset:
Abstract 4316: Suppression of Sp protein expression with Tolfenamic Acid inhibits oral Squamous Cell Carcinoma
Authors: Rafael A. Madero, Chriss M. Lee, Riyaz M. Basha, Maen A. Abdelrahim, Cheryl H. Baker, Thomas D. Shellenberger
Journal: Cancer Research (2011)

Abstract OBJECTIVE: Upregulation of members of the Sp protein family is associated with cell proliferation and metastasis in multiple cancer types. Tolfenamic acid (TA) is a nonsteroidal anti-inflammatory drug shown to inhibit the expression of Sp proteins. We tested the hypothesis that TA inhibits Sp protein expression in human head and neck squamous cell carcinoma lines to suppress cell growth. METHODS: An oral Squamous cell carcinoma cell line (UMSCC-1) was screened for Sp-1 expression, a known target for Tolfenamic Acid (TA). To assess the effect of TA on UMSCC-1 cells, in vitro cell proliferation assays were performed at 24, 48, 72, 96 and 120Hrs, in order to correlate the cell growth response to different drug concentrations (25, 50, 75 and 100 µM). In parallel, Western blot analyses were use to measure Sp-1 expression after 72hrs of drug treatment. In subsequent experiments, we analyzed the effect of TA and radiation on UMSCC-1 under two conditions. Experiment 1: Tolfenamic acid was added 24 hrs after the cells were seeded, and underwent different doses of radiation (5, 10 or 20 Gy) 24 hrs after drug treatment was started. Experiment 2: 24 hrs after seeding UMSCC-1 cells were exposed to different doses of radiation (5, 10 and 20 Gy) and TA was added 24 hrs post-radiation. Cell growth was measure ATP assays. RESULTS: Preliminary results confirmed the presence of Sp-1 expression in the head and neck squamous cell carcinoma cell line, UMSCC-1. In vitro growth analysis showed a direct correlation between cell death and TA concentration. Additionally a synergistic effect was observed when using TA and radiation. Sp-1 has been identified as a transcription factor for the production of Survivin, a protein which is known to be overexpressed in most cancer cells and has been directly linked to the radiation-resistant phenomenon. By regulating the expression of SP-1 using tolfenamic acid, we have demonstrated a reduction and/or complete inhibition of the cancer cells capability to produce Survivin, sensitizing them to radiation. CONCLUSIONS: Our study suggests that TA bears potential in the treatment of oral squamous cell carcinomas as a concomitant agent for traditional chemotherapeutic regimens. In parallel, preliminary data suggest that TA potentiates radiation sensitivity in human head and neck cancer cells. Animal's studies are warranted to further investigate TA in squamous cell carcinoma. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 102nd Annual Meeting of the American Association for Cancer Research; 2011 Apr 2-6; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2011;71(8 Suppl):Abstract nr 4316. doi:10.1158/1538-7445.AM2011-4316
Palatable Drugs for Children
Authors: F. Churchill
Journal: BMJ (1883)

Jinh 9,A18881 '7ffg' z~rnlzr IA M'ALrIJJRi4 .Ma18Avtstearehii etaminatien of the heart now faied to detect thie blight trace .'ofan' ansemic murmur.This favourable condition continued until the fouth daey, when he had a hiemorrhage'from the kidney (the second one).His corpuscles were again estimated, and found to be increased from 16 per cent.to 44 per.cent.He died the same night.'Neo'ropy, twelve hours after death.eate indebted to Dr. Young for his kindness in making a careful and exhaustive post 'mortem examination.His report was as follows.The body was *ell-developed, but considerably emaciated; everywhere the integud ment was jaundiced the conjunctivz were als6 faintly bile-stained.An anuemic appearance was universal.Internal examination showed generally an anemic condition of the organs, most of which' pre- sented a paler but yellower colour than normal, whilst-they were also of softer consistency.The muscles were 'pale and flabby; this was most marked in the walls of the heart,which, beyond dilatation -of 'its cavities, appeared in other respects fairly normal.Its various eavities (but 'especially the right) contained dark-fuid blood, which showed no tendency to coagulation, whilst' it possessed a faint acid rewation.Each lung showed slight hypostatic congestion, and was somewhat cedematous, the fluid' being yellowish in colour.The
Immunodominant epitope of lipocalin allergen bos d 2 is suboptimal for human T cells
Authors: T. Kinnunen, C. Buhot, A. Närvänen, M. Rytkönen-Nissinen, S. Saarelainen, S. Pouvelle-Moratille, J. Rautiainen, A. Taivainen, B. Maillere, R. Mäntyjärvi, T. Virtanen
Journal: Journal of Allergy and Clinical Immunology (2003)
TCT-615 The Effect Of Acute Coronary Syndrome Compared To Stable Angina On The Relationship Between Intravascular Ultrasound Minimal Luminal Area And Fractional Flow Reserve
Authors: Alfazir Omar, Rebecca Torguson, Jacek Legutko, Philippe Genereux, James Blankenship, Jose M De la Torre Hernandez, Farrel Hellig, Tom McAndrew, Gary S. Mintz, Jasvindar Singh, Akiko Maehara, Gregg Stone, Ron Waksman
Journal: Journal of the American College of Cardiology (2013)
Many cancer patients receiving THC as antiemetic
Authors: Phil Gunby
Journal: JAMA (1981)

Tablets containing the active ingredient of marijuana, Δ<sup>9</sup>-tetrahydrocannabinol (THC), are being distributed by the National Cancer Institute (NCI), Bethesda, Md, for use by some patients undergoing cancer chemotherapy. The NCI officials estimate that at present 200,000 Americans may be taking drugs to combat cancer. Perhaps 50,000 of these patients experience refractory nausea and, while estimates vary, it is suggested that THC might help about one half of this group. The potential of THC for combating nausea has been studied since the early 1970s. Not long ago, the Food and Drug Administration finally accepted an advisory committee's recommendation that THC be made available to oncologists for antiemetic therapy (<i>JAMA</i>[MEDICAL NEWS] 1980;243:15-18,1980;244:754). Marijuana is still illegal for most other uses, however, and under the distribution program for cancer patients, hospital pharmacies that stock THC tablets must be approved by the US Department of Justice's Drug Enforcement Administration (DEA). Physicians
Campaign Targets Tobacco Chewing In Little League
Authors: L. Fintor
Journal: JNCI Journal of the National Cancer Institute (1990)

Journal Article Campaign Targets Tobacco Chewing In Little League Get access Lou Fintor Lou Fintor Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 82, Issue 21, 7 November 1990, Page 1670, https://doi.org/10.1093/jnci/82.21.1670 Published: 07 November 1990
Long-Term Outcomes with Drug-Eluting Stents versus Bare-Metal Stents in Sweden
Authors: Bo Lagerqvist, Stefan K. James, Ulf Stenestrand, Johan Lindbäck, Tage Nilsson, Lars Wallentin
Journal: New England Journal of Medicine (2007)

Recent reports have indicated that there may be an increased risk of late stent thrombosis with the use of drug-eluting stents, as compared with bare-metal stents.We evaluated 6033 patients treated with drug-eluting stents and 13,738 patients treated with bare-metal stents in 2003 and 2004, using data from the Swedish Coronary Angiography and Angioplasty Registry. The outcome analysis covering a period of up to 3 years was based on 1424 deaths and 2463 myocardial infarctions and was adjusted for differences in baseline characteristics.The two study groups did not differ significantly in the composite of death and myocardial infarction during 3 years of follow-up. At 6 months, there was a trend toward a lower unadjusted event rate in patients with drug-eluting stents than in those with bare-metal stents, with 13.4 fewer such events per 1000 patients. However, after 6 months, patients with drug-eluting stents had a significantly higher event rate, with 12.7 more events per 1000 patients per year (adjusted relative risk, 1.20; 95% confidence interval [CI], 1.05 to 1.37). At 3 years, mortality was significantly higher in patients with drug-eluting stents (adjusted relative risk, 1.18; 95% CI, 1.04 to 1.35), and from 6 months to 3 years, the adjusted relative risk for death in this group was 1.32 (95% CI, 1.11 to 1.57).Drug-eluting stents were associated with an increased rate of death, as compared with bare-metal stents. This trend appeared after 6 months, when the risk of death was 0.5 percentage point higher and a composite of death or myocardial infarction was 0.5 to 1.0 percentage point higher per year. The long-term safety of drug-eluting stents needs to be ascertained in large, randomized trials.
Abstract 3311: The cholesterol/ 27-hydroxycholesterol axis is a novel therapeutic target in castrate resistant prostate cancer
Authors: Mahmoud A. Alfaqih, Erik R. Nelson, Rachid Safi, Jeff Jasper, Ching-yi Chang, Stephen J. Freedland, Donald P. McDonnell
Journal: Cancer Research (2014)

Abstract The most recent estimates indicate that men have a seventeen percent chance of developing invasive prostate cancer (PCa) over their lifetime. This makes PCa the most commonly diagnosed malignancy among men in industrialized countries, accounting for the second leading cause of cancer-related deaths. Although PCa almost always develops resistance to androgen-deprivation therapy, both androgen receptor (AR) itself and the processes downstream of the receptor remain active and are necessary for cancer progression and thus continue to be viable targets for therapeutic intervention. In this regard, it is of significance that several independent studies demonstrate a link between elevated intra-prostatic levels of cholesterol and the presence of malignancy. This puts into context our current finding that 27-hydroxycholesterol (27HC), a primary metabolite of cholesterol, regulates pathways and processes that oppose AR action. For example, AR activation results in a net uptake of cholesterol by PCa cells and enhances denovo lipogenesis, while 27HC down-regulates genes involved in cholesterol uptake and activates those involved in its efflux. More importantly, we show that treatment of PCa cell lines with 27HC inhibits their proliferation, an activity that is reversed upon supplementing the cells with an exogenous source of cholesterol or upon over-expression of low density lipoprotein receptor (LDLR), a membrane protein that mediates the uptake of cholesterol. In prostatic tissues, 27HC is synthesized directly from cholesterol by the cytochrome P450 enzyme, CYP27A1. To further highlight the above axis as a novel therapeutic target, using data mining approaches from clinical databases, we show that (1) transcript levels of CYP27A1 are dramatically down-regulated during PCa progression and (2) patients whose tumors express high levels of CYP27A1transcript exhibit longer disease free survival. Most notably, we were able to show that over-expression of CYP27A1 inhibits the proliferation of PCa cell lines in vitro and delays the growth of xenografts in castrated immune-deficient mice. In summary, our data thus far strongly implicates that CYP27A1 is a potential tumor suppressor in PCa and highlights the cholesterol/27HC axis as a target for the development of novel therapeutics for castrate resistant disease. Citation Format: Mahmoud A. Alfaqih, Erik R. Nelson, Rachid Safi, Jeff Jasper, Ching-yi Chang, Stephen J. Freedland, Donald P. McDonnell. The cholesterol/ 27-hydroxycholesterol axis is a novel therapeutic target in castrate resistant prostate cancer. [abstract]. In: Proceedings of the 105th Annual Meeting of the American Association for Cancer Research; 2014 Apr 5-9; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2014;74(19 Suppl):Abstract nr 3311. doi:10.1158/1538-7445.AM2014-3311
Simultaneous Coronary Pressure and Flow Velocity Measurements in Humans
Authors: Bernard de Bruyne, Jozef Bartunek, Stanislas U. Sys, Nico H.J. Pijls, Guy R. Heyndrickx, William Wijns
Journal: Circulation (1996)

Background To assess coronary lesion severity in the catheterization laboratory, several guide wire–based methods have been proposed. The purpose of the present study was to compare the feasibility and the reproducibility of coronary flow velocity reserve (CFVR), instantaneous hyperemic diastolic velocity-pressure slope index (IHDVPS), and pressure-derived myocardial fractional flow reserve (FFR myo ). Methods and Results From distal coronary pressure and flow velocity signals (0.014-in guide wires), CFVR, IHDVPS, and FFR myo were computed in 15 stenoses (13 patients) under the four following pairs of conditions: (1) twice under baseline conditions; (2) during atrial pacing at 80 and 110 bpm; (3) before and during intravenous infusion of nitroprusside; and (4) before and during intravenous infusion of dobutamine. A total of 104 measurements were obtained. Both CFVR and FFR myo could be calculated in all cases. IHDVPS could be calculated in only 79% of cases. The mean value of CFVR did not change between the two baseline measurements and during infusion of nitroprusside but decreased from 1.85±0.41 to 1.66±0.45 ( P &lt;.05) during atrial pacing and from 1.90±0.50 to 1.41±0.28 ( P &lt;.05) during dobutamine infusion. The mean values of IHDVPS and FFR myo remained similar, whichever the changes in hemodynamic conditions. The coefficient of variation between two consecutive measurements was significantly lower for FFR myo (4.2%) than for CFVR (17.7%) and for IHDVPS (24.7%). Conclusions CFVR is easy to measure but sensitive to hemodynamic changes. IHDVPS can be measured only in &lt;80% of cases and is highly variable even without changes in hemodynamic conditions. FFR myo is easy to measure and almost independent of hemodynamic changes.
Genetic analysis of self-associating immunoglobulin G rheumatoid factors from two rheumatoid synovia implicates an antigen-driven response.
Authors: T Olee, E W Lu, D F Huang, R W Soto-Gil, M Deftos, F Kozin, D A Carson, P P Chen
Journal: The Journal of Experimental Medicine (1992)

Although much has been learned about the molecular basis of immunoglobulin M (IgM) rheumatoid factors (RFs) in healthy individuals and in patients with mixed cryoglobulinemia and rheumatoid arthritis, little is known about the genetic origins of the potentially pathogenic IgG RFs in the inflamed rheumatoid synovia of patients. Recently, we generated from unmanipulated synovium B cells several hybridomas that secreted self-associating IgG RFs. To delineate the genetic origins of such potentially pathogenic RFs, we adapted the anchored polymerase chain reaction to rapidly clone and characterize the expressed Ig V genes for the L1 and the D1 IgG RFs. Then, we identified the germline counterparts of the expressed L1 IgG RF V genes. The results showed that the L1 heavy chain was encoded by a Vh gene that is expressed preferentially during early ontogenic development, and that is probably located within 240 kb upstream of the Jh locus. The overlap between this RF Vh gene and the restricted fetal antibody repertoire is reminiscent of the natural antibody-associated Vh genes, and suggests that at least part of the "potential pathogenic" IgG RFs in rheumatoid synovium may derive from the "physiological" natural antibody repertoire in a normal immune system. Indeed, the corresponding germline Vh gene for L1 encodes the heavy chain of an IgM RF found in a 19-wk-old fetal spleen. Furthermore, the comparisons of the expressed RF V genes and their germline counterparts reveal that the L1 heavy and light chain variable regions had, respectively, 16 and 7 somatic mutations, which resulted in eight and four amino acid changes. Strikingly, all eight mutations in the complementarity determining regions of the V gene-encoded regions were replacement changes, while only 6 of 11 mutations in the framework regions caused amino acid changes. Combined with L1's high binding affinity toward the Fc fragment, these results suggest strongly that the L1 IgG RF must have been driven by the Fc antigen.
Peripheral blood CD4 T cell gene expression profiles as predictive biomarkers in early arthritis
Authors: A G Pratt, D C Swan, S Richardson, G Wilson, C M U Hilkens, D A Young, J D Isaacs
Journal: Annals of the Rheumatic Diseases (2010)

CD4 T cells are thought to play a crucial role in the pathogenesis of rheumatoid arthritis (RA). Diagnosing the condition, particularly among patients who are seronegative for anticyclic citrullinated peptide (ACPA) antibodies, remains challenging in the clinic. The authors have explored the peripheral blood CD4 T cell transcriptome of early arthritis clinic attendees, looking for biomarkers of potential diagnostic utility.

Total RNA from highly purified peripheral blood CD4 T cells of consenting patients with early arthritis naive to …
Abstract 633: Synergistic interplay between long-term overweight and long menstrual years in endometrial cancer
Authors: Lingeng Lu, Shanming Lee, Susan Mayne, Melinda Irwin, Brenda Cartmel, Harvey Risch, Herbert Yu
Journal: Cancer Research (2012)

Abstract Long-term exposure to estrogen is one of the established mechanisms underlying the development of endometrial cancer. Early menarche, late menopause, low number of pregnancies, and obesity, as risk factors of endometrial cancer, are all linked to this mechanism. However, the synergy among these factors is still less clear. To evaluate the interplay among long-term overweight, menstrual and reproductive features in endometrial cancer, a population-based case-control study was conducted with 668 incident cases and 674 age-matched population controls. Information on menstrual and reproductive features, anthropometric measurements in each decade of adult life as well as hormone replacement therapy was ascertained through a structured questionnaire administered by interviewers. Unconditional logistic regression model was used to examine the associations of these factors with endometrial cancer. As expected, the results show that early menarche, late menopause, low number of pregnancies and live births, and long-term overweight were associated with increased risk. To assess all the menstrual and reproductive factors together, we calculated net menstrual years by subtracting age at menarche from age at menopause, which was further subtracted by the total years of pregnancy. Women with long net menstrual years (&amp;gt; 38 years) had nearly two-fold increases in risk of endometrial cancer (95% CI: 1.43-2.41) compared to those with shorter years (&amp;lt;35 years). Approximately a 3.5-fold increase in risk (95% CI: 2.79-7.04) was observed in those who were overweight since ages 20's or 30's compared to those who maintained BMI under 25 throughout life. Women with both long net menstrual years and long-term overweight combined had over 7-fold increases in risk compared to those with short years and normal weight. These finding suggest that long-term overweight and long menstrual years may have a synergistic effect on endometrial cancer risk. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 103rd Annual Meeting of the American Association for Cancer Research; 2012 Mar 31-Apr 4; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2012;72(8 Suppl):Abstract nr 633. doi:1538-7445.AM2012-633
Multiple basal cell carcinomas arising in port-wine haemangiomas
Authors: M. MAGANA-GARCIA, M. MAGANA-LOZANO
Journal: British Journal of Dermatology (1988)

We report the case of a 49‐year‐old man, who had had two port‐wine stains from birth, in which many basal cell carcinomas developed during his forties. The appearance of multiple basal celt carcinomas in port‐wine stains has not been reported previously to our knowledge and may represent a new syndrome.
99 NOVEL FXR AGONISTS WITH POTENT LIPID LOWERING, INSULIN SENSITISING, ANTI-INFLAMMATORY AND ANTI-FIBROTISATION EFFECTS IN MOUSE MODELS OF METABOLIC SYNDROME AND NASH
Authors: C. Kremoser, E. Hambruch, U. Deuschle, O. Kinzel, M. Burnet, H. Yoneyama
Journal: Journal of Hepatology (2011)
Review recommends duty to share data when in patient's best interests
Authors: C. Dyer
Journal: BMJ (2013)

A new duty to share information between agencies where it is in the patient’s best interests, while strictly protecting patients’ confidential data, has been recommended by a wide ranging review of health information governance in England.1

“The duty to share information can be as important as the duty to protect patient confidentiality,” concludes the review by Fiona Caldicott, former chairwoman of the National Information Governance Board, and an expert panel. It recommends that this statement become a new “Caldicott principle,” along with the six principles set out by Caldicott’s 1997 report on patient confidentiality.

That report was produced at a time when the NHS was more paternalistic and less centred on patients’ …
SILENT MYOCARDIAL ISCHEMIA WITHOUT OBSTRUCTIVE CORONARY ARTERY DISEASE IN RHEUMATOID ARTHRITIS
Authors: Antonios Karanasos, Konstantinos Toutouzas, Eleftherios Tsiamis, Constantina Aggeli, Ioannis Felekos, Evi Zampeli, Athanase Protogerou, George Kitas, Petros Sfikakis
Journal: Journal of the American College of Cardiology (2012)
Activation of the peroxisome proliferator-activated receptor γ promotes the development of colon tumors in C57BL/6J-APCMin/+ mice
Authors: Anne-Marie Lefebvre, Inhua Chen, Pierre Desreumaux, Jamila Najib, Jean-Charles Fruchart, Karel Geboes, Mike Briggs, Rich Heyman, Johan Auwerx
Journal: Nature Medicine (1998)
Regional Myocardial Blood Flow in Patients with Residual Anterior and Inferior Transmural Infarction
Authors: EDWARD M. DWYER, RALPH B. DELL, PAUL J. CANNON
Journal: Circulation (1973)

Regional myocardial perfusion rates were estimated in ten patients with a residual transmural anterior wall infarction and ten patients with a residual transmural inferior infarction. The results in these two groups of patients were compared to the regional myocardial perfusion patterns obtained in 25 patients with normal coronary arteriograms who failed to demonstrate any electrocardiographic evidence of a myocardial infarction. Clearance rates of xenon-133 from multiple areas of the heart were monitored externally with a multiple-crystal scintillation camera following selective injection of the isotope into either coronary artery. Local myocardial blood flow rates were calculated by the Kety formula. In patients with normal coronary arteriograms, mean myocardial perfusion rates in the left ventricle (62 ml/l00g/min) exceeded flow rates in the right ventricle and atrium. There was slight inhomogeneity of local perfusion rates but no significant differences among major subregions (anterior descending, diagonal, or circumflex) within the left ventricle. In the group with an anterior transmural infarction, myocardial blood flow rates were significantly depressed (44 ml/l00g/min) and asynergy was present in the region of the left ventricle supplied by the anterior descending artery, which was &gt;80% narrowed. Diminished capillary blood flow was found in the right ventricular region in the patients with an inferior transmural infarction and right coronary artery narrowing of &gt;80%. There was no evidence of nutrient flow to the inferior surface of the left ventricle after right coronary 133 Xe injection. The data indicate that myocardial perfusion was reduced in regions of the heart which correspond to the electrocardiographic and angiographic location of residual transmural infarction. The perfusion rates observed in areas showing electrocardiographic evidence of transmural infarction and regional ventricular asynergy, although subnormal, were surprisingly high and suggested the presence of residual viable myocardial cells.