ANTIBODY RESPONSE OF PATIENTS WITH PNEUMOCOCCIC PNEUMONIA TREATED WITH SULFADIAZINE AND SULFATHIAZOLE
Authors: Maxwell Finland, Elias Strauss, Osler L. Peterson
Journal: Annals of Internal Medicine (1942)

Article1 January 1942ANTIBODY RESPONSE OF PATIENTS WITH PNEUMOCOCCIC PNEUMONIA TREATED WITH SULFADIAZINE AND SULFATHIAZOLEMAXWELL FINLAND, M.D., F.A.C.P., ELIAS STRAUSS, M.D., OSLER L. PETERSON, M.D.MAXWELL FINLAND, M.D., F.A.C.P.Search for more papers by this author, ELIAS STRAUSS, M.D.Search for more papers by this author, OSLER L. PETERSON, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-16-1-1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe results of immunological studies of a large number of patients with pneumococcic pneumonia treated with sulfapyridine were reported recently from this laboratory.1As far as could be determined, the antibody response of these patients was comparable in every respect to that resulting from spontaneous recovery of similar cases included in previous investigationsin which the same methods were employed.2-6The tests used in the study of the serums from the sulfapyridine treated cases included: agglutinins, which were determined in every instance; mouse protection tests, which were carried out in all cases due to some of the common pneumococcus types; and...References1. FINLANDSPRINGLOWELL MWCFC: Immunological studies on patients with pneumococcic pneumonia treated with sulfapyridine, Jr. Clin. Invest., 1940, xix, 179. CrossrefGoogle Scholar2. FINLANDSUTLIFF MWD: Specific cutaneous reactions and circulating antibodies in the course of pneumonia. I. Cases receiving no specific therapy, Jr. Exper. Med., 1931, liv, 637. CrossrefGoogle Scholar3. FINLANDWINKLER MAW: Antibody response to infections with Type III and the related Type VIII pneumococcus, Jr. Clin. Invest., 1934, xiii, 79. CrossrefGoogle Scholar4. Idem: Antibody response to infections with Type II and the related Type V pneumococcus, Ibid., p. 97. Google Scholar5. WINKLERFINLAND AWM: Antibody response to infections with the newly classified types of pneumococci (Cooper), Ibid., p. 109. Google Scholar6. FINLANDTILGHMANRUEGSEGGERDOWLING MRCJMHF: Clinical and immunological observations in cases of pneumococcus Type VII pneumonia treated with type-specific antibody, Am. Jr. Med. Sci., 1937, cxciii, 59. CrossrefGoogle Scholar7. KNEELANDMULLIKEN YB: Antibody formation in cases of lobar pneumonia treated with sulfapyridine, Jr. Clin. Invest., 1940, xix, 307. CrossrefGoogle Scholar8. Idem: Antibody formation in cases of lobar pneumonia treated with sulfathiazole, Ibid., p. 735. Google Scholar9. BULLOWABUKANTZDE GARA JGSCPF: The balance between capsular polysaccharide and antibody in relation to prognosis and therapy in pneumococcal pneumonia, ANN. INT. MED., 1941, xiv, 1348. Google Scholar10. BRATTONMARSHALL ACEK: A new coupling component for sulfanilamide determination, Jr. Biol. Chem., 1939, cxxviii, 537. CrossrefGoogle Scholar11. FRANCISTILLETT TWS (a) : Cutaneous reactions in pneumonia. The development of antibodies following intradermal injection of type-specific polysaccharides, Jr. Exper. Med., 1930, lii, 573. (b) FINLAND, M., and SUTLIFF, W. D.: Specific antibody response of human subjects to intracutaneous injection of pneumococcus products, Ibid., 1932, lv, 853. (c) FINLAND, M., and DOWLING, H. F.: Cutaneous reactions and antibody response to intracutaneous injections of pneumococcus polysaccharides, Jr. Immunol., 1935, xxix, 285. (d) FINLAND, M., and BROWN, J. W.: Reactions of human subjects to the injection of purified type-specific pneumococcus polysaccharides, Jr. Clin. Invest., 1938, xvii, 479. CrossrefGoogle Scholar12. MCINTOSHWHITBY JLE: The mode of action of drugs of the sulphonamide group, Lancet, 1939, i, 431. CrossrefGoogle Scholar13. LEVINELARSONBIETER MWPRN: Active immunity to pneumococci in rabbits protected by sulfapyridine, Proc. Soc. Exper. Biol. and Med., 1939, xlii, 515. CrossrefGoogle Scholar14. JULIANELLE LA: Reactions of rabbits to intracutaneous injections of pneumococci and their products. I. The antibody response, Jr. Exper. Med., 1930, li, 441. II. Resistance to infection. Ibid., p. 449. CrossrefGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Boston, Massachusetts*Received for publication July 21, 1941.From the Thorndike Memorial Laboratory, Second and Fourth Medical Services (Harvard), Boston City Hospital and the Department of Medicine, Harvard Medical School, Boston.This study was carried out with the technical assistance of Mildred W. Barnes and Clare Wilcox. The chemical determinations were made by Elizabeth Shaler Smith and Alice N. Ballou. 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