THE EFFECT OF PROLONGED ADMINISTRATION OF THYROID
Authors: M W JOHNSTON, A H SQUIRES, R F FARQUHARSON
Journal: Annals of Internal Medicine (1951)

Article1 November 1951THE EFFECT OF PROLONGED ADMINISTRATION OF THYROIDMACALLISTER W. JOHNSTON, A. H. SQUIRES, R. F. FARQUHARSON, F.A.C.P.MACALLISTER W. JOHNSTONSearch for more papers by this author, A. H. SQUIRESSearch for more papers by this author, R. F. FARQUHARSON, F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-35-5-1008 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptINTRODUCTIONThe beneficial effects of continued thyroid therapy in patients suffering from myxedema are remarkable and persistent. On administration of relatively small doses, the basal metabolic rate rises and remains within normal limits as long as the therapy is continued. The symptoms and signs of myxedema disappear and do not recur; sometimes a slightly higher dosage of thyroid is required with the passage of time, but the effectiveness of the drug does not change materially. (See figure 1.) On the other hand, as was pointed out in a former report,1it is often difficult by the administration of similar amounts...Bibliography1. FarquharsonSquires RFAH: Inhibition of the secretion of the thyroid gland by continued ingestion of thyroid substance, Tr. A. Am. Physicians 41: 87, 1941. Google Scholar2. CopeRawsonMcArthur ORWJW: The hyperfunctioning single adenoma of the thyroid, Surg., Gynec. and Obst. 84: 415, 1947. MedlineGoogle Scholar3. RiggsManWinkler DSEBAW: Serum iodine of euthyroid subjects treated with desiccated thyroid, J. Clin. Investigation 24: 722, 1945. CrossrefMedlineGoogle Scholar4. Herring PT: The action of thyroid upon the growth of the body and organs of the white rat, Quart. J. Exper. Physiol. 11: 231, 1917. CrossrefGoogle Scholar5. 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SchoenheimerSperry RWM: Micromethod for determination of free and combined cholesterol, J. Biol. Chem. 106: 745, 1934. CrossrefGoogle Scholar11. SalterJohnston WTMW: Tracing the thyroid hormone in peripheral tissues, J. Clin. Endocrinol. 8: 911, 1948. CrossrefGoogle Scholar12. Johnston MW: Unpublished data. Google Scholar13. Greer MA: Effect on endogenous thyroid activity of feeding desiccated thyroid to normal human subjects, New England J. Med. 244: 385, 1951. CrossrefMedlineGoogle Scholar14. DanowskiManWinkler TSEBAW: Tolerance of normal, of thyroidectomized and of thiourea or thiouracil treated dogs to oral desiccated thyroid and to intravenous thyroxine, Endocrinology 38: 230, 1946. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Toronto, Canada*Presented at the Thirty-second Annual Session of the American College of Physicians, St. Louis, Mo., April 10, 1951.From the Department of Medicine, University of Toronto, and the Medical Service, Toronto General Hospital.†National Research Council Senior Medical Research Fellow. 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