tbuckley/cabot-search huggingface dataset:
790. Regulatable Transgene Expression from Gutless Adenoviral Vectors
Authors: Shyam Goverdhana, Weidong Xiong, Diana S. Greengold, James Curtin, Eric Soffer, Pedro R. Lowenstein, Maria G. Castro
Journal: Molecular Therapy (2004)

Introduction: Gene therapy is not only a powerful but also notably an efficient therapeutic intervention because of the feasibility of gene regulation by exploiting novel tetracycline based transcriptional inducible gene expression systems. Tet-on regulatory switches facilitate gene expression on and off in the presence and absence of doxycycline (Dox) respectively. Novel transactivators such as the Dox dependent transactivator rtTA2S-M2 are effective molecular switches that turn gene expression on as when needed. Negligible or no gene expression in the off state and strong induction kinetics in the on state are main challenges for a safe and effective regulatory system and its subsequent application to the clinic. We examined these factors with tetracycline responsive elements (TRE) and regulatory switches encoded with promoters murine cytomegalovirus m(CMV) and human (h)CMV.
Abstract 3447: Role of fibroblast growth factor receptors in esophageal squamous cell carcinoma
Authors: Yutaka Shimada, Tomoyuki Okumura, Takuya Nagata, Yoshinori Takei, Kazuhiro Tsukada, Kazuharu Shimizu
Journal: Cancer Research (2014)

Abstract Introduction: MicroRNA-210 regulates cancer cell proliferation by targeting fibroblast growth factor receptor-like 1 (FGFRL1) in esophageal squamous cell cancer (ESCC) (JBC 2011). The expression of FGFRL1 has been associated with tumor growth and lymph node metastasis. In the present study, we analyzed and compared the expression of FGFR1, FGFR2, FGFR3, and FGFR4 with that of FGFRL1 using a tissue microarray. We also examined whether antibodies for FGFRL1 inhibited the growth and motility of ESCC cells. Material and Methods: A squamous cell carcinoma tissue microarray established in Toyama University was used to evaluate the expression of the 5 FGFRs. Sixty-nine specimens of ESCC were obtained from 62 male and 7 female patients, with an average age of 64.4 years old, that underwent surgery between 1990 and 2008. The TNM stages of these patients were as follows; stage 1: 7, stage 2a; 10, stage 2b; 10, stage 3; 35, stage 4; 7. The immunohistochemical results of these patients were scored according to intensity and distribution after a careful examination by two independent researchers. The ESCC cell line KYSE520 was used for experimental analyses. Polyclonal and monoclonal antibodies for FGFRL1 were used to evaluate the function of FGFRL1. Results: The percentage of patients who tested positive for the expression of the different FGFRs was as follows: FGFRL-1, 81% (56/69); FGFR1, 65% (37/57); FGFR2, 36% (22/61); FGFR3, 21% (12/57); FGFR4, 39% (22/56). The prognosis of FGFRL1 positive patients was significantly worse than that of FGFRL1 negative patients. (P=0.0311). Both polyclonal and monoclonal antibodies inhibited the growth (50% reduction) and motility (25% reduction) of ESCC cells. However, no association was observed between the expression of the other FGFRs and patient prognosis. Regarding combination analysis of the expression of each FGFR, patients that co-expressed FGFRL1 and FGFR1 had the worst prognosis, while patients who tested negative for the expression of both FGFRL1 and FGFR4 had the best prognosis. Conclusions: Among the 5 FGFRs, the expression of FGFRL1 was the main oncogenic driving factor in ESCC patients. The expression of FGFR1 and FGFR4 may be a sub-driving factor of ESCC. Citation Format: Yutaka Shimada, Tomoyuki Okumura, Takuya Nagata, Yoshinori Takei, Kazuhiro Tsukada, Kazuharu Shimizu. Role of fibroblast growth factor receptors in esophageal squamous cell carcinoma. [abstract]. In: Proceedings of the 105th Annual Meeting of the American Association for Cancer Research; 2014 Apr 5-9; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2014;74(19 Suppl):Abstract nr 3447. doi:10.1158/1538-7445.AM2014-3447
Anesthesia in Dental Surgery
Authors: Sterling V. Mead
Journal: JAMA (1952)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Abstract 9769: Measurement of Myocardial Necrosis Biomarkers After Surgical or Percutaneous Intervention Assessed by Cardiac Magnetic Resonance for Diagnosis of Procedure-Related Myocardial Infarction. The MASS-5 Trial
Authors: Whady Hueb, Paulo C Rezende, Leandro M Costa, Rodrigo M Vieira de Melo, Fernando T Oikawa, Cesar H Nomura, Alexandre V Villa, Celia M Strunz, Alexandre C Hueb, Expedito E Silva, Jose A Ramires, Roberto Kalil Filho
Journal: Circulation (2014)

Introduction: The correlation between the elevation of cardiac biomarkers and diagnosis of procedure-related myocardial infarction (MI) continues to be debated, especially since the emergence of high-sensitive troponin assays (cTnI). However, late gadolinium enhancement (LGE) in cardiac magnetic resonance (CMR) has been established as an alternative for diagnosing AMI. Methods: We prospectively studied 219 patients with stable multivessel coronary artery disease and preserved ventricular function formally indicated for percutaneous or surgical revascularization. Measurements of biomarkers like high-sensitive troponin I (cTnI) and creatine kinase (CKMB) were systematically obtained before and after the procedure, 6, 12, 24, and 36 hours after PCI and up to 72 hours after CABG. Furthermore, CMR was performed in all patients before and after the procedures. The diagnosis of MI was defined as up to 5 times and 10 times the 99th percentile, for PCI and CABG, respectively. Results: Of 219 patients included in t...
By No Extraordinary Means: The Choice to Forgo Life-Sustaining Food and Water.
Authors: Joanne Lynn
Journal: Annals of Internal Medicine (1987)

... compelling.... This book might have been called No Easy Answers. Each of the contributors writes with undisguised urgency.... [W]e should face up to these issues now. By No Extraordinary Means will serve as an impetus and guide. New York Times Book ReviewThis fine new book... thoughtfully written... well edited and cohesively integrated... will be valuable for physicians, nurses, nutritionists, attorneys, members of the clergy, policy makers, and members of the general public. New England Journal of Medicine
The future of clinical forensic medicine
Authors: G. A Norfolk, M. M Stark
Journal: BMJ (1999)

In 1993 the Royal Commission on Criminal Justice considered the role of police surgeons in the criminal justice system. While acknowledging that they performed much valuable work, the commission voiced concerns about a lack of central coordination and quality control of this work.1 The commission recommended that a multidisciplinary Home Office working group should be set up to consider, among other things, the need for establishing centres of excellence at universities and appropriate training and standards for doctors providing clinical forensic services to the police. In 1997 the working group produced a draft report with several recommendations for improving the service, such as the establishment of a national forum to develop accreditation and monitor its effectiveness. No final report has been published, however, and there has been no government backing for the proposals. Despite the unfinished business of addressing the quality of the service, some police forces have contracted out …
A COMMON TYPE OF VERTIGO RELIEVED BY TRACTION OF THE CERVICAL SPINE
Authors: D DAVIS
Journal: Annals of Internal Medicine (1953)

Article1 April 1953A COMMON TYPE OF VERTIGO RELIEVED BY TRACTION OF THE CERVICAL SPINEDAVID DAVIS, M.D.DAVID DAVIS, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-38-4-778 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe purpose of this report is to call attention to a common form of vertigo that is generally unrecognized and often erroneously attributed to cerebral arteriosclerosis. As in true objective vertigo the patient complains that, with a sudden change in head position, objects begin to move, usually revolving clockwise or counter-clockwise. There is a sense of falling to one side, a need to hold on for support or to return to the original bodily position. The mechanism of this vertigo is not established, but clinical evidence is offered to show that it results from cervical nerve root irritation due to...Bibliography1. Davis D: Spinal nerve root pain (radiculitis) simulating coronary occlusion: a common syndrome, Am. Heart J. 35: 70-80, 1948. CrossrefMedlineGoogle Scholar2. DavisRitvo DM: The clinical and roentgen findings in osteoarthritis of the cervicodorsal spine (radiculitis) simulating coronary artery disease, New England J. Med. 238: 857-866, 1948. CrossrefMedlineGoogle Scholar3. Davis D: Respiratory manifestations of dorsal spine radiculitis simulating cardiac asthma, Ann. Int. Med. 32: 954-959, 1950. LinkGoogle Scholar4. Hanflig SS: Pain in shoulder girdle, arm and precordium due to cervical arthritis, J. A. M. A. 106: 523-526, 1936. CrossrefGoogle Scholar5. Kelly LC: Chronic hypertrophic osteoarthritis in the cervical spine with radiculitis, New York State J. Med. Part II, 42: 246-251, 1942; Part III, 42: 336-340, 1942. Google Scholar6. Denney-Brown DE: Neurologic aspects of vertigo, New England J. Med. 241: 144-145, 1949. CrossrefMedlineGoogle Scholar7. Davis D: The nature of the symptoms in essential hypertension, Am. J. M. Sc. 181: 850-856, 1931. CrossrefGoogle Scholar8. Spector B: Neuroanatomic mechanisms underlying vertigo and nausea, Bull. New England M. Center 10: 145-154, 1948. MedlineGoogle Scholar9. Davis D: Unpublished data. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Boston, Massachusetts*Received for publication October 17, 1952. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byCervicogene duizeligheid: een overzicht van diagnostiek en behandelingCervicogenic Dizziness: A Review of Diagnosis and TreatmentEvaluation and Management of Dizziness in the Older PatientPAROXYSMAL POSITIONAL GIDDINESSVertigo, Nausea and VomitusDifferential diagnosis of chest painPostural vertigo due to trigger areas in the sternocleidomastoid muscle 1 April 1953Volume 38, Issue 4Page: 778-786KeywordsNervesSpineVertigo ePublished: 1 December 2008 Issue Published: 1 April 1953 PDF downloadLoading ...
275. Prostate Targeting Peptides Via the Prostate Specific Membrane Antigen
Authors: Jennifer Hu, G. Hallden, Claire Shorrock, Guy Simpson, Rob Coffin, T. Kamalati, R. Coombes
Journal: Molecular Therapy (2004)

Background A genetically modified HSV1, JS1/ICP34.5-/ICP47-, incorporating the hGM-CSF transgene and which selectively replicates and kills tumour cells, is being tested in a Phase I clinical trial in a number of solid tumours. The preliminary results are encouraging and planning for a Phase II clinical trial in combination with chemotherapy in breast cancer is underway. Tumour selectivity is conferred by the deletion of ICP34.5, which is also an anti-apoptotic gene. Deletion of ICP47, which blocks antigen presentation, and the insertion of GM-CSF aims to enhance the immune response to infected malignant cells. The aim of the in vitro work was to assess the effects of combining the virus and paclitaxel in breast cancer cell lines and to study the mechanism of action of the virus, paclitaxel and the combination of the two.
Clinical Pathology of the Eye: A Practical Treatise of Histopathology
Authors: Bernard Samuels, Adalbert Fuchs
Journal: JAMA (1952)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Regular review: Medical management of osteoarthritis
Authors: Karen Walker-Bone, Kassim Javaid, Nigel Arden, Cyrus Cooper
Journal: BMJ (2000)

Osteoarthritis is a common, chronic, musculoskeletal disorder. Symptomatic osteoarthritis, particularly of the knee and hip, is the most common cause of musculoskeletal disability in elderly people. In the Western world it ranks fourth in health impact among women and eighth among men.1 Given this high prevalence, therapeutic approaches to treatment will have to be shared between primary and secondary care. A range of non-surgical interventions has been proposed as components of such a therapeutic strategy.

#### Summary points

Osteoarthritis is a major cause of pain and disability in Western populations

The prevalence of osteoarthritis necessitates a “shared care” approach to management between general practitioners and hospital specialists

Several non-surgical interventions to alleviate pain and disability in lower limb osteoarthritis are now available:

Non-pharmacological measures (education, social support, physiotherapy, and occupational therapy)

Pharmacological measures (simple analgesics, non-steroidal anti-inflammatory drugs, COX-2 inhibitors, topical non-steroidal anti-inflammatory drugs, and capsaicin)

Intra-articular therapy: corticosteroids, hyaluronic acid derivatives, and tidal irrigation

These interventions have been evaluated to varying degrees, but they can be incorporated into an algorithm for the management of osteoarthritis

#### Therapeutic options in osteoarthritis

##### Non-pharmacological treatment

Education (patient and spouse or family)

Social support (telephone contact)

Physiotherapy (aerobic exercises, muscle strengthening, and patellar strapping)

Occupational therapy (aids and appliances, joint protection)

Weight loss

Acupuncture

Transcutaneous electrical nerve stimulation (TENS)

##### Pharmacological treatment

Simple analgesia

Non-steroidal anti-inflammatory drugs

COX-2 inhibitors (cyclo-oxygenase-2 selective non-steroidal anti-inflammatory drugs)

Topical (non-steroidal anti-inflammatory drugs, capsaicin)

Chondroprotective agents

##### Intra-articular treatment

Corticosteroids

Hyaluronans

Tidal irrigation

Systematic reviews and controlled clinical trials were located through Medline and BIDS 1991-9, searching under the key words: osteoarthritis; guidelines; glucosamine; capsaicin; physiotherapy, occupational therapy, acupuncture, drug therapy, education, intra-articular injection, heat, cold, rehabilitation, epidemiology, therapy. When available, the most recent reviews or meta-analyses are cited; if not available, individual controlled trials were included and methodological shortcomings discussed. We did not perform assessments of quality of individual reviews. Semiquantitative estimates …
CONSTITUTIONAL REACTIONS FROM BACTERIAL VACCINES
Authors: Grafton Tyler Brown
Journal: Annals of Internal Medicine (1938)

Article1 October 1938CONSTITUTIONAL REACTIONS FROM BACTERIAL VACCINESGRAFTON TYLER BROWN, B.S., M.D., F.A.C.P.GRAFTON TYLER BROWN, B.S., M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-12-4-493 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptAlthough much has been written about local and focal reactions, little or no attention has been paid to constitutional reactions from bacterial vaccine injections. These systemic bacterial reactions are entirely different from the constitutional reactions sometimes encountered following treatments with food, animal epidermal, pollen, or other kinds of protein extracts. An overdose of vaccine will frequently cause an aggravation of the patient's trouble, but the type of constitutional reaction that I am about to describe is a definite shock reaction, comparable to that produced by the intentional intravenous injection of a small dose of typhoid vaccine in foreign protein therapy.... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Washington, D. C.*Received for publication February 11, 1938. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byAsthma bronchiale 1 October 1938Volume 12, Issue 4Page: 493-494 ePublished: 1 December 2008 Issue Published: 1 October 1938 PDF downloadLoading ...
A Recombinant Soluble Form of the Integrin IIbβ3 (GPIIb-IIIa) Assumes an Active, Ligand-Binding Conformation and Is Recognized by GPIIb-IIIa–Specific Monoclonal, Allo-, Auto-, and Drug-Dependent Platelet Antibodies
Authors: Julie A. Peterson, Gian P. Visentin, Peter J. Newman, Richard H. Aster
Journal: Blood (1998)
Electrical Remodeling of the Human Atrium: Similar Effects in Patients With Chronic Atrial Fibrillation and Atrial Flutter
Authors: Michael R Franz, Pamela L Karasik, Cuilan Li, Jean Moubarak, Mary Chavez
Journal: Journal of the American College of Cardiology (1997)

Objectives. This study sought to determine whether chronic atrial fibrillation (AF) and atrial flutter in patients lead to electrical remodeling of the human atrial myocardium, manifested by an abnormal relation between atrial cycle length and action potential duration (APD). Background. Experimental studies in goats and isolated human atrial tissue have shown that prolonged AF leads to persistent shortening of atrial refractoriness, a phenomenon referred to as electrical remodeling and which helps to explain why AF begets AF. Direct data on human in situ myocardium are still lacking. Methods. Using monophasic action potential recordings at two right atrial sites simultaneously, we determined in 7 patients with chronic AF and 13 with chronic atrial flutter (3 weeks to 3 years in duration) the relation between paced cycle length and APD at 90% repolarization (APD90) 15 to 30 min after conversion to sinus rhythm. APD90 was measured during regularly paced cycle lengths (250 to 800 ms) to determine the steady state cycle length relation and during extrastimulus intervals (from 800 ms to refractoriness) at a basic cycle length of 600 ms to determine electrical restitution curves. The same pacing protocols and measurements were performed in nine control patients with sinus rhythm and no overt atrial disease. Results. In control patients, steady state APD90 increased steadily with increases in cycle length from 250 to 800 ms, reaching a maximal value of 325 ± 41 ms (mean ± SD) at a cycle length of 800 ms. In patients with cardioversion from atrial flutter or AF, the steady state cycle length–APD90 relation was shifted downward and flattened at cycle lengths >400 ms, reaching only 219 ± 44 and 245 ± 39 ms, respectively, at the 800-ms cycle length (p < 0.005 vs. control). The early time course of electrical restitution (200- to 300-ms extrastimulus intervals) was similar between all three groups, but at extrastimulus intervals >350 ms, APD90 was shorter in both the AF and atrial flutter groups than in the control group (p < 0.05). There were no significant differences between patients with cardioversion from atrial flutter and those with cardioversion from AF. APD90 at a steady state cycle length of 600 ms showed no significant correlation with the duration of previous AF or atrial flutter. Conclusions. AF and atrial flutter lead to marked, quantitatively similar decreases in the right atrial APD during steady state pacing and extrastimulation a considerable time after cardioversion. These data confirm that both AF and atrial flutter lead to electrical remodeling in the human atrium, with a preponderance at longer cycle lengths. It may be prudent to abort both types of arrhythmias early to prevent electrical remodeling.