tbuckley/cabot-search huggingface dataset:
ANEURYSM OF THE CORONARY ARTERY
Authors: S TRINIDAD, D M GRAYZEL, P RAPOPORT
Journal: Annals of Internal Medicine (1953)

Case Reports1 November 1953ANEURYSM OF THE CORONARY ARTERYSALVADOR TRINIDAD, M.D., DAVID M. GRAYZEL, M.D., PAUL RAPOPORT, M.D., NORMAN LEE, M.D.SALVADOR TRINIDAD, M.D.Search for more papers by this author, DAVID M. GRAYZEL, M.D.Search for more papers by this author, PAUL RAPOPORT, M.D.Search for more papers by this author, NORMAN LEE, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-39-5-1117 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTrue aneurysm of the coronary arteries is of rare occurrence. Since Bougon1 described the first case in 1812 there have been 48 reported cases in the literature. It would be repetitious to review all the available cases, as various authors, notably Packard and Wechsler,2 Scott,3 Harris4 and Rigdon and Vandergriff5 have made exhaustive studies of the literature pertaining to this rare entity. We are, however, reporting another case of a true aneurysm of the left circumflex coronary artery, which would bring to 49 the total number of authentic cases of coronary aneurysm.CASE REPORTA 59 year old white male...Bibliography1. Bougon : Biblioth. Med. 37: 183, 1812 (cited by Packard and Wechsler2). Google Scholar2. PackardWechsler MHF: Aneurysm of the coronary arteries, Arch. Int. Med. 43: 1-14, 1929. CrossrefGoogle Scholar3. Scott DH: Aneurysms of the coronary arteries, Am. Heart J. 36: 403, 1948. CrossrefMedlineGoogle Scholar4. Harris PN: Aneurysmal dilatation of the cardiac coronary arteries, Am. J. Path. 13: 89, 1937. MedlineGoogle Scholar5. RigdonVandergriff RHH: Aneurysms of the coronary arteries. Review of literature and report of a case, Am. J. Surg. 61: 407, 1943. CrossrefGoogle Scholar6. Rukstinat GJ: Multiple aneurysms of the right coronary artery, J. A. M. A. 149: 1129-1131 (July 19) 1952. CrossrefMedlineGoogle Scholar7. Monahar KD: An aneurysm of the coronary artery, Arch. Path. 26: 1131, 1938. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: *Received for publication May 25, 1953.From the Departments of Medicine and Pathology of the Jewish Hospital, Brooklyn, N. Y. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byManagement of Coronary Artery AneurysmsAcquired coronary arterial aneurysms: An autopsy study of 52 patientsAneurysms of the coronary artery 1 November 1953Volume 39, Issue 5Page: 1117-1124KeywordsAneurysmsCoronary arteriesHospital medicine ePublished: 1 December 2008 Issue Published: 1 November 1953 PDF downloadLoading ...
Left Ventricular Reverse Remodeling After Surgical Therapy for Aortic Stenosis: Correlation to Renin-Angiotensin System Gene Expression
Authors: Thomas Walther, Andreas Schubert, Volkmar Falk, Christian Binner, Claudia Walther, Nico Doll, Alex Fabricius, Stefan Dhein, Jan Gummert, Friedrich W. Mohr
Journal: Circulation (2002)

Surgical therapy for aortic stenosis leads to reverse remodeling, with normalization of left ventricular hypertrophy (LVH). The aim of this study was to examine Renin-Angiotensin system (RAS) gene expression in this setting.Growing sheep (n=44) underwent supracoronary aortic banding for controlled induction of LVH at the age of 6 to 8 months (A=baseline). Surgical revision to completely release the pressure gradient was performed 8.3+/-1 months later (B). The animals were sacrificed after another 10.1+/-2 months (C). Along with hemodynamic measurements, subtractive hybridization and competitive polymerase chain reaction were applied to quantify mRNA expression for angiotensin-converting enzyme (ACE) and angiotensin receptors 1 and 2 (AT1-R and AT2-R).Left ventricular mass index was 82+/-21 g (A), 150+/-33 g (B), and 78+/-18 g (C), P<0.01. Left ventricular function and cardiac index remained stable. Myocardial fiber diameter was 11.3+/-0.8 (A), 15.9+/-1.2 (B), and 11.4+/-1 (C) microm, P<0.01. Gene expression was as follows: ACE 0.8+/-0.05 (A), 1.3+/-0.08 (B), and 0.9+/-0.06 (C), P<0.01; AT1-R 0.7+/-0.06 (A), 0.9+/-0.07 (B), and 0.3+/-0.04 (C), P<0.01; AT2-R 0.5+/-0.05 (A), 0.2+/-0.04 (B), and 0.5+/-0.05 (C), P<0.01.LVH in aortic stenosis coincides with significant alterations of the RAS. Surgical therapy leads to reverse remodeling, which is paralleled by regression of RAS gene expression.
Abstract P021: NT-proBNP Predicts Incident Heart Failure Among Individuals in All BMI Categories
Authors: Chiadi E Ndumele, Kunihiro Matsushita, Yingying Sang, Mariana Lazo, Sunil K Agarwal, Vijay Nambi, Anita Deswal, Roger S Blumenthal, Christie M Ballantyne, Josef Coresh, Elizabeth Selvin
Journal: Circulation (2014)

Background: The N-Terminal of pro-Brain Natriuretic Peptide (NT-proBNP) is a potent predictor of incident HF in the general population. Persons with obesity, despite their predisposition to developing HF, are known to have low NT-proBNP levels. The utility of NT-proBNP for HF prediction among individuals with obesity is therefore unclear. Hypothesis: We hypothesized that NT-proBNP levels may predict incident HF differently across body mass index (BMI) categories. Methods: We followed 12,509 ARIC participants free of prior HF at baseline (Visit 2, 1990-1992) with BMI ≥18.5 kg/m2 and available NT-proBNP. BMI (kg/m2) was categorized as normal (18.5-24.9), overweight (25-29.9), obese (30-34.9) and severely obese (≥35). The primary outcome was incident HF (1,986 events during a mean follow-up of 15.8 years). The potential effect modification of obesity on the NT-proBNP-HF relationship was assessed on both relative and absolute scales using multivariable Cox regression models. We also evaluated whether NT-proBNP improves HF prediction beyond traditional risk factors within the ARIC HF Risk Score similarly across BMI categories. Results: As expected, higher BMI was associated with lower NT-proBNP (r=-0.09, p&lt;0.0001). Within each BMI category, higher NT-proBNP levels were significantly and similarly associated with increased relative risk for HF (Figure 1A). However, given the higher incidence of HF associated with obesity, the absolute risk difference associated with higher NT-proBNP levels was greatest among individuals with severe obesity (Figure 1B). In all BMI categories, NT-proBNP significantly improved the C-statistic beyond the ARIC HF Risk Score (increases of 0.026 [0.009-0.043] and 0.033 [0.015-0.052] for normal weight and severely obese, respectively). Conclusions: Despite the inverse relationship between NT-proBNP and obesity, NT-proBNP provides significant prognostic information regarding HF risk in all BMI categories, supporting its use for HF prediction even among those with obesity.
Glucocorticoid receptors and glutamine synthetase in leukemic Sézary cells.
Authors: Schmidt Tj, Thompson Eb
Journal: Cancer Research (1979)

Using a competitive binding assay, we have detected cytoplasmic glucocorticoid receptors in the leukemic cells of several patients with Sezary syndrome, while cells from other patients appear to contain very low or nondetectable receptor levels. The receptors are saturated at approximately 4 × 10-8 m [3H]dexamethasone, and Scatchard analyses of the binding data indicate a high affinity (Kd = 6.9 × 10-9 m). The cytoplasmic receptors are inactivated at 37°, but at 4° they are relatively stable, even in the absence of glucocorticoids. Competition studies have established the specificity of these receptors. Active glucocorticoids such as dexamethasone, prednisolone, and cortisol (50-fold molar excess) completely block [3H]dexamethasone binding, while nonglucocorticoids such as 17β-estradiol and 5α-dihydrotestosterone have no effect at equivalent concentrations. The antiinducer progesterone is also an effective competitor of [3H]dexamethasone binding. The [3H]dexamethasone-receptor complex migrates in linear 5 to 20% sucrose gradients (0.4 m KCI) with a sedimentation coefficient of 4S20,ω. In those cells which contained receptors, the specific activity of glutamine synthetase was increased 2-fold after an 18-hr exposure to dexamethasone (10-6 m), whereas no such increase occurred in cells lacking receptor. The presumptive induction of glutamine synthetase activity may thus serve as a marker for functional receptors in leukemic Sezary cells. Retrospective studies (4 patients) suggest a possible correlation between receptor levels and clinical responsiveness to glucocorticoid therapy.
In vivo CAMPATH-1H prevents graft-versus-host disease following nonmyeloablative stem cell transplantation
Authors: Panagiotis D. Kottaridis, Donald W. Milligan, Rajesh Chopra, Ronjon K. Chakraverty, Suparno Chakrabarti, Stephen Robinson, Karl Peggs, Stephanie Verfuerth, Ruth Pettengell, Judith C. W. Marsh, Stephen Schey, Premini Mahendra, Gareth J. Morgan, Geoff Hale, Herman Waldmann, M. Carmen Ruiz de Elvira, Catherine D. Williams, Stephen Devereux, David C. Linch, Anthony H. Goldstone, Stephen Mackinnon
Journal: Blood (2000)
Laboratory Methods of the United States Army.
Authors: James Stevens Simmons
Journal: JAMA (1930)

The medical officers who served in the division of infectious diseases in laboratories of the United States Army during the war of 1917-1918 may remember the first edition of "Laboratory Methods of the United States Army," published in 1918. This was a small pocket manual of 256 pages, a true vade mecum for the laboratory worker. This fifth edition, of 823 pages, each of which is double the size of the page of the first edition, is a comprehensive laboratory manual. It is dedicated to the memory of Dr. George M. Sternberg, who was Surgeon General of the United States Army during the last decade of the nineteenth century. The editors have enlisted the services of twenty-three contributors, all of them either officers in the army or closely related as consultants in special fields. The book is divided into eleven parts as follows: "Clinical Pathology," "Chemistry," "Mycology," "Bacteriology," "Rickettsiae and
Open versus laparoscopic cholecystectomy in acute cholecystitis. Systematic review and meta-analysis
Authors: Federico Coccolini, Fausto Catena, Michele Pisano, Federico Gheza, Stefano Fagiuoli, Salomone Di Saverio, Gioacchino Leandro, Giulia Montori, Marco Ceresoli, Davide Corbella, Massimo Sartelli, Michael Sugrue, Luca Ansaloni
Journal: International Journal of Surgery (2015)
Balancing benefits and harms in health care
Authors: L. G. Cuervo
Journal: BMJ (2003)

We need to get better evidence about harms 

Should kids be plastered with sunscreen this summer? Is this likely to be more beneficial than harmful? How would we know? For example, sunscreen use has been associated with overexposure to the sun, perhaps because of overconfidence in its abilities.1 2 Might there also be a potential risk of developing contact allergies, skin irritation, and rare but severe adverse effects? People making a decision about whether or not to use sunscreen need reliable evidence on the balance of benefits and harms. The same is true of all healthcare interventions, and unfortunately reliable evidence on harms is often lacking.

Great progress has been made in obtaining reliable evidence on the beneficial effects of interventions, but developments in the identification, interpretation, and reporting of harmful effects is more challenging. Randomised controlled trials are the best way to evaluate small to moderate effects of healthcare interventions, and much of the evidence for benefits from treatment comes from such studies. However, they are not always suitable to evaluate harms, and this was made clear during a recent meeting jointly organised by the Cochrane Collaboration and BMJ Knowledge in London.

There are various problems with randomised controlled trials in relation to harms and some of these problems affect systematic reviews too. Firstly, trialists may know which benefits to assess …
A patient who changed my practice: Patients not protocols
Authors: E. A McClure
Journal: BMJ (1999)

“Dear Dr Elizabeth,

“I am returning the Lipitor tablets as well as the Zocor. I take them about 3.0p.m.; the first 2days they did not have much effect, but on Thursday I had some aches and pains and wobbles and on Friday 1did not know where to put myself in the evening! Alright, after a night's sleep.

“A year or so ago, I remember you saying that 6.5wasn't too bad a cholesterol level at my age, then you read something …
Phase II study of induction docetaxel/cisplatin with rhG-CSF followed by concurrent pulsed docetaxel chemoradiation for stage III non-small cell lung cancer (NSCLC)
Authors: Y. Chen, K. J. Pandya, T. Smudzin, R. Qazi, B. D. Smith, O. Hyrien, D. W. Johnstone, T. Watson, R. H. Feins
Journal: Journal of Clinical Oncology (2006)

17034 Background: Both local and distant failures contribute to poor outcome in chemoradiation (CRT) for stage III NSCLC. Our previous study applied pulsed low-dose paclitaxel CRT for stage III NSCLC yielded 97.6% in-field tumor control and a modest survival gain. A follow-up study was designed to target distant micrometastasis up-front by one-cycle induction (IND) chemotherapy (CT) w/o further delay of local therapy. This was followed by low-dose sensitizing docetaxel (Doc) CRT. Methods: IND CT consisted of day 1 Doc 75 mg/m 2 &amp; cisplatin 75 mg/m 2 , and rhG-CSF (150 mg/m 2 days 2–10). CRT started 3–6 wks later. Twice-weekly Doc at 12 mg/m 2 was given with daily RT of 64.8 Gy to gross dz and 45–57.6 Gy to subclinical dz. Toxicity (Tox), response and survival were assessed. Results: 22 pts enrolled with 16 evaluable. 6 did not complete due to: allergy, intercurrent dz or progressive dz prior-to/during RT. Overall response was 69%. Kaplan-Meier survival was 67%, 55%, and 55% for years 1, 2, and 3. Grade (Gd) 3 Tox of IND CT included: allergy (10%), infection/nl ANC (20%), nausea (10%), HTN (5%) hyperglycemia (5%), H/A (5%), fatigue (10%), dyspnea/gd 4 hyperglycemia/fatigue (5%). No gd 3/4 hematologic Tox. Esophagitis was the main Tox of CRT. Doc was reduced after 10th pt enrolled for high incidence of gd 3 esophagitis: 4/8 (50%) at Doc dose of 12 mg/m 2 . Subsequent pts received reduced Doc of 10 mg/m 2 and 1/8 had gd 3 esophagitis (12.5%). Other gd 3 Tox of CRT included: fatigue (14%), appetite loss (14%), flushing (7%), chest pain (7%), diarrhea (7%), and nausea (28%). No other gd 3 or 4 Tox from CRT. Conclusion: The regimen is associated with low hematologic Tox. Despite published MTD of twice-weekly Doc/RT at 15 mg/m 2 , 50% treated at 12 mg/m 2 had gd 3 esophagitis. This was reduced to 12.5% at 10 mg/m 2 . Local response was 69% and survival was much better compared with our previous study of pulsed paclitaxel/RT w/o IND CT, which yielded 2 and 3-year survival of 33% and 18% for all, and 40% and 21% for pts completed protocol (Chen et al Clin Cancer Res 9:969–975,2003). Data suggest that one-cycle IND CT followed by low-dose taxane-based CRT improves survival of stage III NSCLC pts and deserves further investigation. Study partly supported by Sanofi-Aventis. No significant financial relationships to disclose.
Abstract 4387: Up-regulation of VHL by miR-1273C inhibits renal cell carcinoma
Authors: Chang Woo Lee, Moo Rim Kang, Jieun Yun, Soo Jin Oh, Jong Soon Kang
Journal: Cancer Research (2014)

Abstract VHL (Von Hippel-Lindau) is a known tumor suppressor that binds to hypoxia inducible factor (HIF) and induces ubiquitin-mediated degradation. VHL is also involved in the regulation of tumor angigoenesis, cell cycle regulation, and apoptosis. Recent studies have reported that double strand RNA complementary to target promoter sequence can induce gene expression in several cancer cells and this is called small activating RNA (saRNA). By scanning gene promoters in silico for sequences complementary to known miRNAs, we identified 32 putative miRNAs target site in the promoter of VHL. Experimental validation identified two miRNAs (miR-1273C and miR-4512) that induce VHL expression in 769-P renal cancer cells. Another dsRNA molecule (dsVHL-101) complementary to the putative miR-1273C target site also induced VHL expression. Functional studies revealed that transfection of miR-1273C and dsVHL-101 inhibited cell proliferation and induced apoptosis in dose dependent manner. Furthermore, knockdown experiments confirmed that induction of VHL and apoptosis by miR-1273C and dsVHL-101 required the miRNA maturation protein Ago2 and nuclear transport protein TNRC6A. This study suggests that miRNAs play an inhibiting role in the progression of cancer cells by VHL gene expression, which may be a potential therapeutic approach in the future. Citation Format: Chang Woo Lee, Moo Rim Kang, Jieun Yun, Soo Jin Oh, Jong Soon Kang. Up-regulation of VHL by miR-1273C inhibits renal cell carcinoma. [abstract]. In: Proceedings of the 105th Annual Meeting of the American Association for Cancer Research; 2014 Apr 5-9; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2014;74(19 Suppl):Abstract nr 4387. doi:10.1158/1538-7445.AM2014-4387
Treatment of venous leg ulcers with cryopreserved cultured allogeneic keratinocytes: a prospective open controlled study
Authors: None Lindgren, None Marcusson, None ToftgÅrd
Journal: British Journal of Dermatology (1998)

Twenty-seven patients with chronic venous leg ulcers were assigned to two treatment groups. Fifteen were treated with cryopreserved cultured allogeneic keratinocyte sheets and compression bandages and 12 with compression only. The observation time was 8 weeks and the keratinocyte grafting procedure was performed once weekly. The mean reduction of the initial wound area was 35% in the treatment group and 14% in the control group. This difference was not significant. The poor effect on wound healing given by the cryopreserved allogeneic keratinocyte sheets contrasts with our earlier experience using fresh keratinocyte sheets. We believe that this is due to a weakened condition of the cryostored cells, as we have shown a loss in protein synthesis capacity of at least 50%.
Linear cutaneous lupus erythematosus following the lines of Blaschko
Authors: None Abe, None Ishikawa, None Miyachi
Journal: British Journal of Dermatology (1998)

We describe two Japanese girls with discoid lupus erythematosus (DLE) in whom the condition showed a linear configuration following the lines of Blaschko. The clinical appearance was unusual but histological examination established the diagnosis. After reviewing the previous reports, we found that in six of eight patients with linear 'discoid' lesions, the age at onset was under 14 years; no patient has progressed to systemic lupus erythematosus. Patients with 'linear' DLE may compose a certain clinical subset. We propose the term 'linear cutaneous lupus erythematosus' which may be more suitable for the linear lesions of DLE.
Role for macrophage inflammatory protein (MIP)-1α and MIP-1β in the development of osteolytic lesions in multiple myeloma
Authors: Masahiro Abe, Kenji Hiura, Javier Wilde, Keiji Moriyama, Toshihiro Hashimoto, Shuji Ozaki, Shingo Wakatsuki, Masaaki Kosaka, Shinsuke Kido, Daisuke Inoue, Toshio Matsumoto
Journal: Blood (2002)
Consumption of vegetables, fruit, and antioxidants during pregnancy and wheeze and eczema in infants
Authors: Y. Miyake, S. Sasaki, K. Tanaka, Y. Hirota
Journal: Allergy (2010)

To cite this article: Miyake Y, Sasaki S, Tanaka K, Hirota Y. Consumption of vegetables, fruit, and antioxidants during pregnancy and wheeze and eczema in infants. Allergy 2010; 65 : 758–765. Abstract Background: Two previous cohort studies showed inverse relationships between maternal vitamin E and zinc intake during pregnancy and the risk of wheeze and/or asthma in the offspring. We investigated the association between maternal intake of vegetables, fruit, and selected antioxidants during pregnancy and the risk of wheeze and eczema in the offspring aged 16–24 months. Methods: Subjects were 763 Japanese mother–child pairs. Data on maternal intake during pregnancy were assessed with a diet history questionnaire. Data on symptoms of wheeze and eczema were based on criteria of the International Study of Asthma and Allergies in Childhood. Results: Higher maternal intake of green and yellow vegetables, citrus fruit, and β‐carotene during pregnancy was significantly associated with a reduced risk of eczema, but not wheeze, in the offspring {adjusted odds ratios (ORs) between extreme quartiles [95% confidence intervals (CIs)] = 0.41 (0.24–0.71), 0.53 (0.30–0.93), and 0.52 (0.30–0.89), respectively}. Maternal vitamin E consumption during pregnancy was significantly inversely related to the risk of infantile wheeze, but not eczema [adjusted OR (95% CI) = 0.54 (0.32–0.90)]. No statistically significant exposure–response associations were observed between maternal intake of total vegetables, vegetables other than green and yellow vegetables, total fruit, apples, α‐carotene, vitamin C, or zinc and the risk of wheeze or eczema in the children. Conclusions: Higher maternal consumption of green and yellow vegetables, citrus fruit, and β‐carotene during pregnancy may be protective against the development of eczema in the offspring. Higher maternal vitamin E intake during pregnancy may reduce the risk of infantile wheeze.
Systematic quantification of tumour content in cryopreserved samples stored in a lung tumour bank
Authors: Edwina Duhig, Belinda Clarke, Maria Martins, Felicia Goh, Ian Yang, Kevin Matar, Morgan Windsor, Paul Zimmerman, Morgan Davidson, Casey Wright, Rayleen Bowman, Kwun M. Fong
Journal: Journal of Thoracic Oncology (2011)