ORAL ANTIDIABETIC THERAPY
Authors: R H WILLIAMS, R H POLLEN, D C TANNER, R H BARNES
Journal: Annals of Internal Medicine (1959)

Article1 December 1959ORAL ANTIDIABETIC THERAPYROBERT H. WILLIAMS, M.D., F.A.C.P., RICHARD H. POLLEN, M.D., DONALD C. TANNER, M.D., ROBERT H. BARNES, M.D.ROBERT H. WILLIAMS, M.D., F.A.C.P.Search for more papers by this author, RICHARD H. POLLEN, M.D.Search for more papers by this author, DONALD C. TANNER, M.D.Search for more papers by this author, ROBERT H. BARNES, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-51-6-1121 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThere is some evidence suggesting that the majority of patients with diabetes have subnormal concentrations of insulin in the plasma, but a hypernormal quantity of insulin has been demonstrated in certain instances. Insulin administration has proved to be of tremendous value, especially in those types of diabetes which seem to be associated with subnormal amounts of this hormone, for example, juvenile diabetes. Nevertheless, almost all of the juvenile diabetics develop one or more of the chronic complications of diabetes (retinopathy, intercapillary glomerulosclerosis, etc.) within an interval of 20 years, regardless of ardent efforts by the patients and their physicians to...Bibliography Symposia:1. The effects of the sulfonylureas and related compounds in experimental and clinical diabetes, Ann. New York Acad. Sc. 71: 4-292, 1957. CrossrefMedlineGoogle Scholar2. Chlorpropamide and diabetes mellitus, Ann. New York Acad. Sc., in press. Google Scholar3. Experimental and clinical studies of the oral therapy of diabetes mellitus, Deutsche med. Wchnschr. 81: 823-846, 887-906, 1956. MedlineGoogle Scholar4. Experimental and clinical studies of the oral therapy of diabetes mellitus, Deutsche med. Wchnschr. 82: 1513-1592, 1957. Google Scholar5. Third Lilly Conference on Carbutamide, Diabetes 6: 1-94, 1957. MedlineGoogle Scholar6. Symposium on clinical and experimental effects of sulfonylureas in diabetes mellitus, Metabolism 5: 721-977, 1956. MedlineGoogle Scholar7. Proceedings of the Third Congress of the International Diabetes Federation, Dusseldorf, July, 1958, 1959, Georg Thieme, Stuttgart. Google Scholar8. Conference on insulin and oral hypoglycemic agents, Metabolism 8: 469-686, 1959. MedlineGoogle Scholar9. Conference on current trends in research and clinical management of diabetes, N. Y. Acad. Sc., Sec. of Biol. and Med. Sc., April 10-11, 1959, New York. Google Scholar10. Symposium on "A New Oral Hypoglycemic Agent, Phenformin (DBI)," Houston, Feb. 5-6, 1959. Google Scholar11. Goldner MG: Oral hypoglycemic agents, past and present, Arch. Int. Med. 102: 830, 1959. CrossrefGoogle Scholar12. LevineSobel RGW: The mechanism of action of the sulfonylureas in diabetes mellitus, Diabetes 6: 263, 1957. CrossrefMedlineGoogle Scholar13. Loubatieres A: The mechanism of action of the hypoglycemic sulfonamides, Diabetes 6: 408, 1957. CrossrefMedlineGoogle Scholar14. Mirsky IA: Orally effective hypoglycemic agents, Pennsylvania M. J. 61: 861, 1958. MedlineGoogle Scholar15. WilliamsMartinHenleySwanson RHFBEDHE: Inhibitors of insulin degradation, Metabolism 8: 99-113, 1959. MedlineGoogle Scholar16. Lewis JJ: Diabetes and the insulin-administration problem, Physiol. Rev. 29: 75, 1949. CrossrefMedlineGoogle Scholar17. O'Donovan CH: Analysis of long-term experience with tolbutamide (Orinase) in the management of diabetes, unpublished data, 1958. Google Scholar18. MehnertCamerini-DavalosMarble HRA: Results of long-term use of tolbutamide (Orinase) in diabetes mellitus, J. A. M. A. 617: 818, 1958. CrossrefGoogle Scholar19. UngerMadison RHLL: A new diagnostic procedure for mild diabetes mellitus, Diabetes 7: 455, 1958. CrossrefMedlineGoogle Scholar20. Iezzoni DG: Personal communication, 1959. Google Scholar21. Kirtley WR: Personal communication, 1959. Google Scholar22. O'Donovan CJ: Personal communication, 1959. Google Scholar23. WilliamsSteiner RHDF: Summarization of studies relative to the mechanism of phenethylbiguanide hypoglycemia, Metabolism 8: 548, 1959. MedlineGoogle Scholar24. OdellTannerSteinerWilliams WDDCDFRH: Phenethyl-amyland isoamylbiguanide in the treatment of diabetes mellitus, Arch. Int. Med. 102: 520, 1958. CrossrefGoogle Scholar25. KrallCamerini-Davalos LPR: Clinical trials with DBI, a new non-sulfonylurea oral hypoglycemic agent, Arch. Int. Med. 102: 25, 1958. CrossrefGoogle Scholar26. KrallBradley LPRF: Clinical evaluation of formamidinyliminourea, a new biguanide oral blood sugar lowering compound: comparison with other hypoglycemic agents, Ann. Int. Med. 50: 586-613 (Mar.) 1959. LinkGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: *Received for publication May 16, 1959.Presented at the Fortieth Annual Session of The American College of Physicians, Chicago, Illinois, April 23, 1959.From the Department of Medicine, University of Washington School of Medicine, Seattle, Washington.†Aided by Grant No. A2456 from the National Institute of Arthritis and Metabolic Diseases, U. S. Public Health Service, and the Diabetes Teaching and Research Foundation (Seattle).With the assistance of FRED T. DARVILL, M.D., Mount Vernon, Washington, WILLIAM H. STIMSON, M.D., HOWARD M. HACKEDORN, M.D., SYDNEY WEINSTEIN, M.D., and WILLIAM J. KELLY, M.D., Seattle, Washington.Requests for reprints should be addressed to Robert H. Williams, M.D., Department of Medicine, University of Washington, Seattle 5, Washington. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byTolazamide HepatotoxicityZur Pharmakologie und Toxikologie der blutzuckersenkenden SulfonamideHypoglycemic and uricosuric properties of acetohexamide and hydroxyhexamideIntraventricular conduction defect and respiratory tract paralysis in diabetic ketoacidosisNebenwirkungen und Gefahren der AntidiabeticaPHENFORMIN (PHENETHYLBIGUANIDE) IN THE TREATMENT OF DIABETES MELLITUS: A PRELIMINARY REPORTChlorpropamide in Patients on High Insulin DosageAssessment of Treatment with Tolbutamide in Diabetes Mellitus1CHOLESTATIC JAUNDICE FROM TOLBUTAMIDE*R. WILLIAM BAIRD, M.D., JOHN G. HULL, M.D. 1 December 1959Volume 51, Issue 6Page: 1121-1133KeywordsBlood plasmaHypoglycemicsInsulinInsulin secretionMedical servicesMetabolic disordersPancreasProteinsRetinopathyType 1 diabetes ePublished: 1 December 2008 Issue Published: 1 December 1959 Copyright & PermissionsCopyright ©, 1959, by The American College of PhysiciansPDF downloadLoading ...