Marrow Iron
Authors: L. D. ELLIS
Journal: Annals of Internal Medicine (1964)

Article1 July 1964Marrow IronAn Evaluation of Depleted Stores in a Series of 1,332 Needle BiopsiesL. D. ELLIS, M.D., W. N. JENSEN, M.D., F.A.C.P., M. P. WESTERMAN, M.D.L. D. ELLIS, M.D.Search for more papers by this author, W. N. JENSEN, M.D., F.A.C.P.Search for more papers by this author, M. P. WESTERMAN, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-61-1-44 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptExamination of the bone marrow for stainable iron has been considered to be "the most valuable clinical procedure for determining adequacy of body iron stores" (1). Increased concentrations have been observed in patients with pernicious anemia, hemolytic anemias, marrow aplasia, uremia, chronic infection, hemochromatosis, and hemosiderosis (2). Decreased or absent marrow iron stores have been consistently reported in patients with iron deficiency anemia (2-7), observed in "tired young women" (3), and described in association with rheumatoid arthritis (8,9). The absence of marrow iron stores is generally accepted as the "sine qua non of iron deficiency" (10). Previous studies of marrow...References1. BOTHWELLFINCH THCA: Iron Metabolism, Little, Brown and Co., Boston, 1963, p. 286. Google Scholar2. BEUTLER E: Clinical evaluation of iron stores. New Eng. J. Med. 256: 692, 1957. CrossrefMedlineGoogle Scholar3. BEUTLERROBSONBUTTENWIESER EMJE: A comparison of the plasma iron, iron binding capacity sternal marrow iron, and other methods in the clinical evaluation of iron stores. Ann. Intern. Med. 48: 60, 1958. LinkGoogle Scholar4. PRATTJOHNSON PTME: Marrow iron stores in anemia. Arch. Intern. Med. (Chicago) 93: 725, 1954. CrossrefGoogle Scholar5. DAVIDSONJEMISON WMRF: The relationship between iron storage and anemia. J. Clin. Path. 5: 281, 1952. CrossrefMedlineGoogle Scholar6. HUTCHISON HE: The significance of stainable iron in sternal marrow sections. Blood 8: 236, 1953. CrossrefMedlineGoogle Scholar7. STEVENSCOLEMANFINCH ARDHCA: Iron metabolism: clinical evaluation of iron stores. Ann. Intern. Med. 38: 199, 1953. LinkGoogle Scholar8. RICHMONDGARDNERROYDUTHRIE JDLLMJJ: Nature of anemia in rheumatoid arthritis. III. Changes in the bone marrow and their relation to other features of the disease. Ann. Rheum. Dis. 15: 217, 1956. CrossrefMedlineGoogle Scholar9. MCCREA PC: Marrow iron examination in the diagnosis of iron deficiency in rheumatoid arthritis. Ann. Rheum. Dis. 17: 89, 1958. CrossrefMedlineGoogle Scholar10. HARRIS JW: The Red Cell, Harvard University Press, Cambridge, Mass., 1963, p. 53. Google Scholar11. RATHFINCH CECA: Sternal marrow hemosiderin. J. Lab. Clin. Med. 33: 81, 1948. MedlineGoogle Scholar12. MCFARLANDDAMESHEK WW: Biopsy of bone marrow with Vim-Silverman needle. JAMA 166: 1464, 1958. CrossrefMedlineGoogle Scholar13. BLOCKJACOBSONBETHARD MLWF: Bone marrow studies in polycythemia. J. Clin. Invest. 31: 618, 1952 (abstract). Google Scholar14. VERLOOPMEEUWISSENBLOKHUIS MCTJEW: Comparison of the "iron absorption test" with the determination of the iron binding capacity of serum in the diagnosis of iron deficiency. Brit. J. Haemat. 4: 70, 1958. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Pittsburgh, PennsylvaniaFrom the Department of Medicine, School of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania 15213.Supported in part by research grants H-6270 and 2A-5106, U. S. Public Health Service.Dr. Ellis is a Fellow in Hematology, Dr. Jensen is Professor of Medicine, and Dr. Westerman is Assistant of Professor of Medicine at the University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania.Presented at the Forty-fifth Annual Session of the American College of Physicians, Atlantic City, New Jersey, April 6-10, 1964.Requests for reprints should be addressed to Maxwell P. Westerman, M.D., Assistant Professor of Medicine, School of Medicine, Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania 15213. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byPeripheral Effects of Iron DeficiencyMicrocytic anemia: Differential Diagnosis and Management of Iron Deficiency AnemiaIron stores in essential thrombocythaemiaDecreased bone marrow iron in chronic granulocytic leukaemia: A consistent finding not reflecting iron deficiencyDecreased stainable marrow iron in chronic granulocytic leukemiaBone Marrow Status of Anaemic Pregnant Women on Supplemental Iron and Folic Acid in a Nigerian CommunityFerritin levels in patients with microcytic anaemia complicating pulmonary tuberculosisDas Serumferritin in der Differentialdiagnose der AnämieBone Marrow Studies in MyelomatosisIron Deficiency in Patients with Chronic Obstructive Airways DiseaseIron Deficiency: Still a Diagnostic ChallengePolyglobulie und Polycythaemia veraDiagnostic Value of Marrow Hemosiderin PatternsROBERT K. NIXON, M.D., F.A.C.P., JOHN P. OLSON, M.D.Polycythaemia Vera: Differential Diagnosis by Ferrokinetic Studies and Treatment with Busulphan (Myleran*)The Effect of Iron Stores on Ferrokinetics in PolycythaemiaIdiopathic hemochromatosisAndrogens and Erythropoiesis 1 July 1964Volume 61, Issue 1Page: 44-49KeywordsAnemiaBone marrowHemolytic anemiaIron deficiencyIron deficiency anemiaMedical servicesPernicious anemiaPolycythemiaResearch grantsRheumatoid arthritis Issue Published: 1 July 1964 PDF downloadLoading ...