Spontaneous Remission in Chronic Lymphocytic Leukemia
Authors: P A Chervenick, D R Boggs, M M Wintrobe
Journal: Annals of Internal Medicine (1967)

Case Studies1 December 1967Spontaneous Remission in Chronic Lymphocytic LeukemiaP. A. CHERVENICK, M.D., DANE R. BOGGS, M.D., M. M. WINTROBE, M.D., PH.D., F.A.C.P.P. A. CHERVENICK, M.D.Search for more papers by this author, DANE R. BOGGS, M.D.Search for more papers by this author, M. M. WINTROBE, M.D., PH.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-67-6-1239 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptAlthough spontaneous remissions have been reported to occur in leukemia (1-3) and many other types of cancer (4), rarely have such remissions been observed in chronic lymphocytic leukemia (CLL). An apparent spontaneous and prolonged remission in a patient with typical findings of CLL, which began 18 months after cessation of all therapy, is the subject of this report.CASE REPORTPatient S. O.,*a 48-year-old mechanic, developed symptoms of weakness and easy fatigability in 1952. A hemoglobin determination was reported to be 10.6 g/100 ml. Several weeks later he was hospitalized with a hemoglobin of 6.0 g/100 ml and a...References1. SOUTHAMCRAVERDARGEONBURCHENAL CMLFHWJH: A study of the natural history of acute leukemia with special reference to the duration of the disease and the occurrence of remissions. Cancer 4: 39, 1951. CrossrefMedlineGoogle Scholar2. BIERMANCRILEDODKELLYPETRAKISWHITESHIMKIN HRDMKSKHNLLPMB: Remissions in leukemia of childhood following acute infectious disease: Staphylococcus and Streptococcus varicella, and feline panleukopenia. Cancer 6: 591, 1953. CrossrefMedlineGoogle Scholar3. FREIREICHFREIHOLLANDPINKELSELAWRYROTHBERGHAURANITAYLORGEHAN EJEJFDOHFREA: Evaluation of a new chemotherapeutic agent in patients with "advanced refractory" acute leukemia. Studies of 6-azauracil. Blood 16: 1268, 1960. CrossrefMedlineGoogle Scholar4. 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Author, Article, and Disclosure InformationAffiliations: Salt Lake City, UtahFrom the Department of Medicine, University of Utah College of Medicine, Salt Lake City, Utah.This investigation was supported by research grant AM-04489 and graduate training grant 2A5098, National Institute of Arthritis and Metabolic Diseases, National Institutes of Health, Bethesda, Md.Requests for reprints should be addressed to Dane R. Boggs, M.D., Department of Medicine, Rutgers Medical School, New Brunswick, N. J. 08903.*See Figure 1 for the patient's course over 14 years. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byComplete Spontaneous Regression of Chronic Lymphocytic LeukemiaHodgkin's disease developing after spontaneous remission of chronic lymphocytic leukemiaHAEMATOLOGICAL REMISSION OF LEUKAEMIC POLYMORPHIC IMMUNOCYTOMA FOLLOWING SPLENECTOMYSpontaneous remission following bone marrow necrosis in chronic lymphocytic leukaemiaSpontaneous regression in non-Hodgkin's lymphomaSpontaneous remission of leukemic lymphoproliferative disease 1 December 1967Volume 67, Issue 6Page: 1239-1242KeywordsArthritisChronic lymphocytic leukemiaGraduate medical educationHemoglobinLymphocytic leukemiaMetabolic disordersResearch grantsSalts ePublished: 1 December 2008 Issue Published: 1 December 1967 PDF downloadLoading ...