tbuckley/cabot-search huggingface dataset:
Dandruff/seborrhoeic dermatitis is characterized by an inflammatory genomic signature and possible immune dysfunction: transcriptional analysis of the condition and treatment effects of zinc pyrithione
Authors: K.J. Mills, P. Hu, J. Henry, M. Tamura, J.P. Tiesman, J. Xu
Journal: British Journal of Dermatology (2012)

Background Dandruff/seborrhoeic dermatitis is a common scalp condition that is characterized by flakes, pruritus and sometimes mild erythema. These symptoms reflect tissue level events that are poorly understood at the molecular level. Objectives The purpose of this work was: (i) to compare gene expression profiles in subjects with dandruff vs. those of subjects without dandruff to determine the key physiological disruptions manifest in the condition; and (ii) to determine the effect on this profile of treatment with a shampoo containing potentiated zinc pyrithione (ZPT). Methods In study 1, scalp biopsies were taken from 16 normal subjects and from involved and uninvolved sites in 15 subjects with dandruff. In study 2, 30 subjects with dandruff were treated for 3 weeks with a commercial ZPT shampoo (n = 15) or a vehicle (n = 15), and scalp lesional biopsies were collected at baseline and end of study for transcriptomic analysis. RNA was extracted from all biopsies and Affymetrix gene chips were used to analyse transcriptomic profiles, followed by bioinformatic analysis. Results Analysis of study 1 biopsies revealed more than 7000 individual probes differentially regulated in dandruff lesional skin relative to normal. Enriched Gene Ontology categories included: lipid metabolism, immune response, response to stimulus, apoptosis, cell proliferation, and epidermal development. The most striking feature of lesional skin relative to normal was the reciprocal expression of induced inflammatory genes and repressed lipid metabolism genes. Induced inflammatory genes were also enriched in dandruff uninvolved skin, suggesting the existence of predisposing factors associated with inflammation. Many genes increased in lesional skin were increased at the level of protein in stratum corneum samples (e.g. IL-1RA, S100A8, S100A9, S100A11, IL-8). Under conditions known to improve overall scalp condition, the ZPT shampoo treatment in study 2 produced a transcriptomic profile resembling that of normal scalp skin. Conclusions These data provide novel insights into the nature of dandruff and the therapeutic action of potentiated ZPT-containing shampoo, and provide a basis to explore many new mechanistic questions related to these topics.
The Step 2 Clinical Skills Exam
Authors: Elmer Philip Lehman, Jason Ross Guercio
Journal: New England Journal of Medicine (2013)

We agree with the Perspective article by Lehman and Guercio (March 7 issue) 1 that national clinical exams are expensive.We also agree with First et al. 2 that such exams positively shape the educational and assessment programs of medical schools, promote standardization of accreditation criteria, and provide an essential service to the public by filtering out candidates in need of remediation of deficient skills.We feel, however, that a crucial aspect has been ignored so far: the effect of the exam on all students taking it.4][5] We may ignore to our peril the implied warning that without a mandatory high-stakes clinical skills exam, too many new graduates may lack the clinical skills deemed critical to effective health care.Considering its positive effects, a national clinical skills exam seems an excellent value proposition indeed.
Decreased regional cortical gray matter volume in schizophrenia
Authors: T E Schlaepfer, G J Harris, A Y Tien, L W Peng, S Lee, E B Federman, G A Chase, P E Barta, G D Pearlson
Journal: American Journal of Psychiatry (1994)

The authors hypothesized that cortical gray matter volume reduction in schizophrenia is greatest in the heteromodal association cortex. This area comprises a highly integrated, reciprocally interconnected system that coordinates higher order cortical functions.Total brain and regional gray matter volumes were calculated in 46 schizophrenic patients and 60 age and sex-matched comparison subjects by using magnetic resonance images. Disease specificity was examined by assessing 27 patients with bipolar disorder. Approximations to the dorsolateral prefrontal cortex, inferior parietal lobule, and superior temporal gyrus were selected as regions of interest for the heteromodal association cortex. Occipital and sensorimotor areas were used as comparison regions to test the hypothesis for regional specificity.Gray matter volume was reduced in schizophrenic patients in index regions even after covariance for overall brain volume, sex, and age. Bipolar disorder patients did not exhibit heteromodal gray matter reduction. Comparison regions did not differ among the three groups. Global gray matter volume was not different among groups after covariance for global brain volume. Comprehensive individual region post hoc analysis found no additional gray matter differences.These findings support the theory of disproportionate reduction of gray matter volume in the heteromodal association cortex specific to schizophrenia.
Abstract 18411: Sirolimus Stents, Late Incomplete Stent Malapposition, in Stent Restenosis, Oh My- Glagov’s Phenomenon Revisited
Authors: Jonathan E Feig, Rony Shimony, Daniel E Soffer
Journal: Circulation (2014)

A 52-year-old female with a history of hyperlipidemia and hypothyroidism presented with intermittent chest discomfort after minimal exertion. Her past medical history is significant for two mid left anterior descending artery (mLAD) Cypher sirolimus stents (2.5mm x 23mm, 2.5mm x 8mm) placed in 2008 when she presented with a NSTEMI. Her medications were aspirin, amlodipine, pitavastatin, synthroid and a multivitamin. Electrocardiogram demonstrated normal sinus rhythm. Physical exam was unremarkable and cardiac enzymes were negative. Baseline ejection fraction was 60% and there were no wall motion abnormalities during stress echocardiogram. Due to recurrent chest discomfort, CT angiography (CTA) was ordered which revealed two sequential stents with the proximal end of the first stent appearing outside the vessel lumen. Coronary angiography revealed ISR in the mLAD with contrast outside the proximal stent. Optical coherence tomography (OCT) was used which demonstrated positive remodeling, late incomplete stent malapposition (ISA) and ISR. Since studies have shown that the staining outside the sirolimus stent and ISA were associated with very late stent thrombosis, we decided that percutaneous coronary intervention (PCI) was not the ideal treatment. We opted for robotic coronary artery bypass graft (CABG) surgery with LIMA-LAD. The patient was discharged five days later without any complications. This case highlights the value of multi-modality imaging which revealed a Cypher related process despite a negative stress test. These observations led us to reason that we need a more permanent solution for treatment and therefore we referred the patient for CABG. It also raises important issues such as the duration of dual anti-platelet therapy in patients who have Cypher stents. Although Glagov’s phenomenon was originally described only for the case of arterial remodeling in response to growth of atherosclerotic plaques, our case emphasizes how a similar process can occur after PCI depending on the stent type. In conclusion, this case illustrates the limitations of angiography which is simply luminography, the complementary roles of CTA and OCT, and how multi-modality imaging can play a critical role in helping direct clinical-decision making.
Development of an enhanced proteomic method to detect prognostic and diagnostic markers of healing in chronic wound fluid
Authors: M.L. Fernandez, J.A. Broadbent, G.K. Shooter, J. Malda, Z. Upton
Journal: British Journal of Dermatology (2007)

Background Chronic venous leg ulcers are a significant cause of pain, immobility and decreased quality of life for patients with these wounds. In view of this, research efforts are focused on multiple factors in the wound environment to obtain information regarding the healing of ulcers. Objectives Chronic wound fluid (CWF), containing a complex mixture of proteins, is an important modulator of the wound environment, and therefore we hypothesized that these proteins may be indicators of the status of wounds and their potential to heal or otherwise. To explore this we developed and validated a proteomic approach to analyse CWF. Methods In this study, pooled CWF was depleted of high abundant proteins using immunoaffinity chromatography. The flow‐through and bound fractions were collected, concentrated, desalted and analysed using a range of techniques. Each fraction was further separated using two‐dimensional (2D) gel electrophoresis and 2D liquid chromatography and analysed using mass spectrometry (MS). Results Western blot analysis against three high abundant proteins confirmed the selective removal of these proteins from CWF. Critically, one‐dimensional and 2D gel electrophoresis indicated that subsequent removal of these proteins enhanced the ability to detect proteins in low abundance in CWF. Further, MS demonstrated that depletion of these abundant proteins increased the detection of other proteins in these samples. Conclusions Results obtained indicate that this approach significantly improves separation of proteins present in low concentrations in CWF. This will facilitate the identification of biomarkers in samples collected from patients with ulcers and lead to improved patient therapies and wound care approaches.
THE EXPERIMENTAL AND PATHOLOGICAL ASPECTS OF SILICOSIS
Authors: Dudley Irwin
Journal: Annals of Internal Medicine (1935)

Article1 November 1935THE EXPERIMENTAL AND PATHOLOGICAL ASPECTS OF SILICOSISDUDLEY IRWINDUDLEY IRWINSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-9-5-540 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe purpose of this paper is to present certain aspects of human and experimental silicosis and to report some of the recent advances in this subject, along with some of the difficulties that are being encountered by its investigators.Silicosis is an industrial disease of increasing importance that has been recognized by the clinician for the past hundred years. Formerly this condition was known by many names, such as grinder's rot, miner's phthisis and stonemason's lung. Gradually these occupational diseases were found to be associated with the inhalation of dust in the corresponding trades. The pathological lesions in these pulmonary... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Toronto, Ontario, Canada*Read at the Philadelphia meeting of the American College of Physicians, April 30, 1935.From the Department of Medical Research, University of Toronto. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 November 1935Volume 9, Issue 5Page: 540-546KeywordsDustInhalationLesionsLungsSilicosis ePublished: 1 December 2008 Issue Published: 1 November 1935 PDF downloadLoading ...
Abstract 19346: Peak Oxygen Consumption Predicts Outcome in Hypertrophic Cardiomyopathy
Authors: Carla Contaldi, Raffaella Lombardi, Alessandra Giamundo, Sandro Betocchi
Journal: Circulation (2014)

Introduction: Peak oxygen consumption (VO 2 ) has a strong and independent prognostic value in systolic heart failure; in contrast no data support its prognostic role in hypertrophic cardiomyopathy (HCM). Hypothesis: We assess if peak VO 2 is a long-term predictor of outcome in HCM. Methods: We studied 92 HCM patients (40±15 years). Peak VO 2 was expressed as percentage (%) of the predicted value. Follow up was 76±57 months. The primary composite endpoint (CE) was atrial fibrillation, progression to NYHA class III or IV, myotomy-myectomy (MM), heart transplantation (HT) and cardiac death. An ancillary endpoint (HFE) included markers of heart failure (progression to NYHA class III or IV, MM and HT). Results: At baseline, 62% of patients were asymptomatic, 35% NYHA class II and 3% NYHA class III; 26% had left ventricular outflow tract obstruction. During follow up, 30 patients met CE with 43 events. By multivariate Cox survival analysis, we analyzed 2 models, using the CE, and in turn HFE. For CE, maximal left atrial diameter (LAD) (HR: 1.12; 95% CI: 1.04 to 1.22), maximal wall thickness (MWT) (HR: 0.14; 95% CI: 1.04 to 1.23) and % predicted peak VO 2 (HR: -0.03; 95% CI: 0.95 to 0.99) independently predicted outcome (overall, p&lt;0.0001). For HFE, maximal LAD (HR:0.31; 95% CI: 1.09 to 1.70), MWT (HR: 0.35; 95% CI: 1.08 to 1.84) and % predicted peak VO 2 (HR: -0.06; 95% CI: 0.89 to 0.98) independently predicted outcome (overall, p&lt;0.0001). Only 19% of mildly symptomatic or asymptomatic patients with % predicted peak VO 2 &gt;80% had events, as opposed to 53% of them with % predicted peak VO 2 &lt; 55% (p= 0.04). Event-free survival for both endpoints was significantly lower in patients with % predicted peak VO 2 &lt; 55% as compared to those with it between 55 and 80 and &gt;80% , Figure. Conclusion: In mildly or asymptomatic patients severe exercise intolerance may precede clinical deterioration. In HCM, peak VO 2 provides excellent risk stratification with a high event rate in patients with % predicted value &lt;55%.
Association between HLA‐DRB1 polymorphisms and pemphigus vulgaris: a meta‐analysis
Authors: L. Yan, J‐M. Wang, K. Zeng
Journal: British Journal of Dermatology (2012)

Several studies have reported that HLA-DRB1 may be correlated with pemphigus vulgaris (PV), but most have been based on small samples and the results remain inconsistent and unclear.To investigate the correlation between DRB1 and PV by a meta-analysis of case-control/nonfamily studies.PubMed, Wiley Online Library, ScienceDirect, Google Scholar, Cochrane Library, Chinese National Knowledge Infrastructure and Wanfang databases were searched for studies including: (i) 'pemphigus'; and (ii) 'human leukocyte antigen', 'HLA', 'major histocompatibility complex', 'MHC' or 'DRB1'. Eighteen selected studies were used in meta-analyses to evaluate DRB1 alleles and phenotypes by calculating the respective odds ratios (ORs) and 95% confidence intervals (CIs). Stratified meta-analyses and meta-regression analysis were also conducted.The frequencies of three genotypes (allele and phenotype, respectively) were significantly increased in PV: DRB1*04 [P-value for comparability (Pc) < 0.00001, OR 3.61, 95% CI 2.28-5.71; Pc = 0.0002, OR 4.14, 95% CI 1.98-8.65], DRB1*08 (Pc = 0.03, OR 2.25, 95% CI 1.07-4.70; Pc = 0.0003, OR 2.46, 95% CI 1.51-4.01) and DRB1*14 (Pc < 0.00001, OR 6.47, 95% CI 4.52-9.26; Pc < 0.00001, OR 9.68, 95% CI 4.47-20.98). Three others (allele and phenotype, respectively) were significantly decreased in PV: DRB1*03 (Pc < 0.00001, OR 0.28, 95% CI 0.19-0.41; Pc = 0.0001, OR 0.25, 95% CI 0.12-0.51), DRB1*07 (Pc = 0.004, OR 0.45, 95% CI 0.26-0.78; Pc = 0.0002, OR 0.27, 95% CI 0.14-0.54) and DRB1*15 (Pc = 0.001, OR 0.35, 95% CI 0.18-0.66; Pc = 0.002, OR 0.32, 95% CI 0.16-0.65). Ethnicity partially explained the heterogeneity of DRB1*07, DRB1*08 and DRB1*14 phenotypes.Our findings suggest that DRB1*04, DRB1*08 and DRB1*14 are statistically significant susceptibility factors for PV. Conversely, DRB1*03, DRB1*07 and DRB1*15 may be negatively associated with PV. Specific HLA-DRB1 types may influence the susceptibility or resistance to PV, which needs further investigations.
Nonfatal fall-related injuries associated with dogs and cats --- United States, 2001--2006
Authors: Judy A. Stevens, Tadesse Haileyesus, Usa Prevention
Journal: MMWR Morbidity and Mortality Weekly Report (2009)

Falls are the leading cause of nonfatal injuries in the United States. In 2006, nearly 8 million persons were treated in emergency departments (EDs) for fall injuries. Pets might present a fall hazard, but few data are available to support this supposition. To assess the incidence of fall-related injuries associated with cats and dogs, CDC analyzed data from the National Electronic Injury Surveillance System All Injury Program (NEISS-AIP) for the period 2001--2006. This report describes the results of that analysis, which showed that an estimated average of 86,629 fall injuries each year were associated with cats and dogs, for an average annual injury rate of 29.7 per 100,000 population. Nearly 88% of injuries were associated with dogs, and among persons injured, females were 2.1 times more likely to be injured than males. Prevention strategies should focus on 1) increasing public awareness of pets and pet items as fall hazards and of situations that can lead to fall injuries and 2) reinforcing American Veterinary Medical Association recommendations emphasizing obedience training for dogs. Language: en
Abstract 16125: Novel Role for Insulin-Like Growth Factor-1 Receptors (Igf-1r) in Endothelial Function and Repair: Studies in an Endothelial Igf-1r Overexpressing Transgenic Model
Authors: Helen Imrie, Afroze Abbas, Hema Viswambharan, Piruthivi Sukumar, Nadira Yuldasheva, Matthew C Gage, Stacey L Galloway, Richard Cubbon, Jessica Smith, Matthew B Kahn, Vivek Baliga, Victoria K Gatenby, Stephen B Wheatcroft, Mark T Kearney
Journal: Circulation (2011)

Endothelium-derived nitric oxide (NO) is a critical regulator of vascular homeostasis, repair and regeneration. We recently demonstrated that decreasing the proportion of insulin resistant hybrid r...
Edmondo and Thérèse Morbilli
Authors: M. Therese Southgate
Journal: JAMA (2000)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Accidents in History, by Ed Roger Cooter, Bill Luckin
Authors: L. Evans
Journal: BMJ (1997)

Ed Roger Cooter, Bill Luckin: Wellcome Trust, £16, pp 273 ISBN 90 420 0093 7

Accidents in History is a compilation of 10 essays, many of them from a 1991 conference with the same title. The content is mainly philosophical, semantic, and rhetorical. The emphasis is on the process of thinking about the nature and definition of accidents, not structured information about past catastrophes. There are interesting facts, but they are spread through the book and generally embedded in all too many words. The essays are, on average, about 8000 words each.

Several of the essays identify many difficulties and ambiguities that surround the word “accident.” None, however, points out that professionals in …
479. KLN-47, a Safe Lipophosphoramide Reagent, Efficiently Transfects (&gt;100 kb) Large Plasmids into Epithelial Cells
Authors: Stefania Xenariou, Uta Griesenbach, Ramsay Bowden, Elizabeth Hillery, Ann Doherty, Duncan Geddes, David Porteous, Christian Plank, Eric Alton, A. Christopher Boyd
Journal: Molecular Therapy (2004)
The National Children's Study of environmental effects on child health and development.
Authors: Amy M Branum, Gwen W Collman, Adolfo Correa, Sarah A Keim, Woodie Kessel, Carole A Kimmel, Mark A Klebanoff, Matthew P Longnecker, Pauline Mendola, Marc Rigas, Sherry G Selevan, Peter C Scheidt, Kenneth Schoendorf, Eleanor Smith-Khuri, Marshalyn Yeargin-Allsopp
Journal: Environmental Health Perspectives (2003)

Increasing recognition that children may be more susceptible than adults to environmental exposures and that they experience potentially life-long consequences of such exposures has led to widespread support for a large new cohort study in the United States. In this article, we propose a framework for a new cohort study of children, with follow-up beginning before birth and continuing to age 21 years. We also describe the administrative structure that has been built to develop the proposal further. The structure includes a partnership between federal and nonfederal scientists and relies on a collaborative, interdisciplinary research effort of unprecedented scale in medical research. We discuss briefly how the proposed cohort could be used to examine, among many other things, the effect of chemical contaminants in breast milk on children's health and development.
HEMATOLOGICAL RESPONSE OF ADDISONIAN PERNICIOUS ANEMIA TO BREWER'S YEAST
Authors: Hollis K. Russell
Journal: Annals of Internal Medicine (1934)

Article1 May 1934HEMATOLOGICAL RESPONSE OF ADDISONIAN PERNICIOUS ANEMIA TO BREWER'S YEASTHOLLIS K. RUSSELL, M.D.HOLLIS K. RUSSELL, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-7-11-1398 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptRecently Strauss and Castle1 postulated that Addisonian pernicious anemia is due to the lack of a specific (hematopoietic) reaction between an extrinsic, dietary factor (vitamin B2), and an intrinsic factor present in normal gastric juice. In Addisonian anemia the lack of the specific reaction is due to an absence of intrinsic factor, and the extrinsic factor alone will not produce a hematological response. We have tested this theory on four cases of Addisonian pernicious anemia and the results form the basis of this report.OUTLINE OF TECHNICAL PROCEDUREAfter the diagnosis of Addisonian pernicious anemia was established these patients were...References1. STRAUSSCASTLE MBWB: Nature of extrinsic factor of deficiency state in pernicious anemia and in related macrocytic anemias; activation of yeast derivatives with normal human gastric juice, New England Jr. Med., 1932, ccvii, 55-59. CrossrefGoogle Scholar2. MURPHYMONROEFITZ WPRTR: Changes in composition of blood in pernicious anemia treated by diet rich in liver, Jr. Am. Med. Assoc., 1927, lxxxviii, 1211-1214. CrossrefGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: HOLLIS K. RUSSELL, M.D.Affiliations: Valhalla, N. Y.*Received for publication January 26, 1934.From the laboratory of Grasslands Hospital. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 May 1934Volume 7, Issue 11 Page: 1398-1402 Keywords Hematology and oncology Pernicious anemia Research laboratories ePublished: 1 December 2008 Issue Published: 1 May 1934 PDF downloadLoading ...
Successful treatment with 5-fluorouracil of conjunctival intraepithelial neoplasia refractive to mitomycin-C1 1The authors have no financial interests in the products or devices mentioned in this article.
Authors: Noriaki Yamamoto, Tomohisa Ohmura, Hiroyuki Suzuki, Haruyuki Shirasawa
Journal: Ophthalmology (2002)