tbuckley/cabot-search huggingface dataset:
Abstract 5895: The Impact of Response to Cardiac Resynchronization Therapy on Ventricular Arrhythmic Events
Authors: Kenji Ando, Yoshimitsu Soga, Takeshi Arita, Shinichi Shirai, Masahiko Goya, Masashi Iwabuchi, Hiroyoshi Yokoi, Hitoshi Yasumoto, Hideyuki Nosaka, Masakiyo Nobuyoshi, Satoshi Shizuta, Takahiro Doi, Takeshi Kimura, Toru Kit
Journal: Circulation (2008)

Background: It’s well known that cardiac resynchronization therapy (CRT) is effective to reduce heart failure hospitalization. However, the impact of response to CRT on ventricular arrhythmic events is not well established. Methods: We investigated 216 pts received CRT in two institutions (age 69.3+/−10.8 years, NYHA class 3.1+/−0.5, LVEF 25.8+/−7.4%, LVEDD 62.1+/−8.3mm, pre QRS duration 158+/−32ms, AF 19.4%, ischemic heart disease 33.3%, CRT-D 51.3%) and divided into two groups, Responders (n=145, 67.1%) and Non-responders (n=71, 32.9%). CRT responder was defined as improvement of LVEF &gt; or =5%, or reduction of LVEDD &gt; or = 5mm at 3–6 month echo data. Long-term ventricular arrhythmic events (ventricular tachycardia: VT, ventricular fibrillation: VF and sudden cardiac death: SCD) were obtained. Kaplan-Meier curve were draw and Long-Rank test was used to compare event rates of two groups. Results: Mean follow up periods was 19.3 +/−12.7 months. Event free survival rates from ventricular arrhythmic events (VT, VF and SCD) were all significantly higher in Responders compared to Non-responders (VT: 89.2% vs. 77.8% at 2 year, Log-rank p=0.031, VF: 99.2% vs. 89.9% at 2 year, Log-rank p=0.0031, SCD: 98.6% vs. 89.2% at 2 year, Log-rank p=0.0038) and event free survival rate from combined VT, VF and SCD was also significantly higher in Responders (87.8% vs. 76.5% at 2 year, Log-rank p=0.0013). Conclusion: Response to CRT seems to reduce not only heart failure events, but also ventricular arrhythmic events. Figure: Adverse events in new onset AF vs no AF
Abstract 19732: Low Calorie Cranberry Juice Reduces Risk Factors of Cardiovascular Disease in Adults
Authors: Janet A Novotny, David J Baer, Christina Khoo, Sarah Gebauer
Journal: Circulation (2012)

Foods rich in phenolics are associated with reduced risk for cardiovascular disease. Cranberry juice is rich in a variety of phenolic compounds, including flavonoids. We conducted a double-blind, placebo controlled randomized clinical trial to investigate the effect of daily consumption of a low calorie cranberry juice beverage on risk factors of cardiovascular disease. Volunteers (n=26 men and n=30 women), aged 51+11 years, with a body weight of 79.3+8.8 kg and BMI of 28.4+4.3 (mean+SD) consumed a low calorie cranberry juice beverage or a color/flavor/calorie-matched placebo beverage as part of a controlled diet for 8 weeks. The controlled diet consisted of typical American foods, and menus were scaled to meet volunteers’ individual energy requirements such that body weight did not change during the study. Fasting blood samples were collected immediately prior to the intervention and after 4 weeks and 8 weeks of treatment. Outcome variables were compared between treatments with a mixed model ANOVA, and values at 4 weeks and 8 weeks of treatment were compared to baseline with a repeated measures ANOVA. After 8 weeks of cranberry juice beverage consumption, c-reactive protein was significantly lower compared to that after consumption of the placebo beverage (LSmeans+SEM of 2.74+0.56 mg/L for cranberry juice compared to 3.83+0.59 mg/L for placebo). Soluble ICAM-1 was also significantly lower after consumption of cranberry juice compared to placebo (LSmeans+SEM of 257.3+10.6 ng/mL for cranberry juice compared to 288.9+11.1 ng/mL for placebo). In addition, triglycerides were significantly reduced from baseline when volunteers consumed the cranberry juice (mean+SEM reduction of 14.2+5.7 mg/dL for cranberry juice compared to 1.5+4.9 mg/dL for placebo. The significant decrease in c-reactive protein, an important biomarker of inflammation and a clinically relevant risk factor for several cardiovascular diseases, suggests that cranberry juice beverage could ameliorate an underlying physiological state (inflammation) associated with risk for disease. Incorporation of a low calorie cranberry juice beverage into the diet of adults appears to reduce risk factors of cardiovascular disease.
Abstract 3037: Immuno-inflammatory Cascade Activation and Restenosis in Stable and Unstable Angina Patients Undergoing Coronary Interventions
Authors: Georgia Karabela, Stamatis Adamopoulos, George Karavolias, Antigoni Haidaroglou, Dimitrios Degiannis, Vassilis Voudris, Dimitrios T Kremastinos
Journal: Circulation (2008)

Background: Inflammation is an important feature of atherosclerotic lesions and associated with the development of restenosis after coronary angioplasty. The purpose of this study was to investigate whether “active” coronary plaque disruption during percutaneous coronary intervention (PCI), further provokes the activation of immuno-inflammatory cascade and predisposes to restenosis, in stable and unstable angina patients. Methods and Results: We assessed the levels of soluble intercellular adhesion molecule (s-ICAM-1), vascular adhesion molecule (s-VCAM-1), metalloproteinase (MMP-9), metalloproteinase inhibitor (TIMP-2), monocyte chemoattractant proteine-1 (MCP-1), T cells chemoattractant proteine IP-10, interleukine-6 (IL-6), C-reactive proteine (CRP) and anti-inflammatory marker IL-10, in 43 stable angina (SA) and 46 unstable angina (UA) patients, before, 12 h and 40 h after PCI. As a control group, we studied 19 SA and 20 UA patients, after coronary angiography. After PCI, serum levels of VCAM-1, MMP-9, IL-6 and CRP increased significantly in both groups, in SA ( p &lt; 0.01) and UA ( p &lt; 0.001) , while levels of ICAM-1, MCP-1, IP-10, TIMP and IL-10, did not change significantly. After diagnostic angiography, a significant elevation in CRP was observed in SA patients ( p =0.04), while no difference in any inflammatory marker was detected in UA patients. At 6 months follow-up, 27 out of 89 pts underwent re-angiography because of: positive stress test in 25 pts and UA in 2 pts. Restenosis (lumen diameter stenosis ≥50%) was observed in 12 pts (14%). A positive correlation (p=0.04) was found between IL-10 levels at 12h post-PCI and in stent restenosis (Relative risk [RR]=1.14, 95% CI 1.006 –1.2933). We found no correlation between in-stent restenosis and all the other inflammatory markers. Conclusion: Our results provide further evidence of the role of iatrogenic plaque disruption inducing immunoinflammatory responses detectable in systemic circulation, especially in UA patients. The elevation of anti-inflammatory cytokine IL-10 after PCI is associated with in-stent restenosis. This anti-inflammatory marker, strong indicator of an activated inflammatory process, could probably be used as independent predictor of in-stent restenosis.
Abstract 18409: Long-Term Mortality Following On- and Off-Pump Coronary Artery Bypass Graft Surgery
Authors: Chuntao Wu, Fabian Camacho, Edward L Hannan
Journal: Circulation (2011)

Background: There are limited data on the relative survival following on- and off-pump coronary artery bypass graft (CABG) surgery during follow-up periods longer than 5 years. Objectives: To examine the difference in 7-year mortality after on- and off-pump isolated CABG surgery. Methods: A total of 5,940 on-pump and 2,640 off-pump isolated CABG patients discharged between October 1 and December 31, 2000 were identified using the New York State's Cardiac Surgery Reporting System. The patients' vital statuses through the end of 2007 were determined by matching to the National Death Index. We fit a logistic regression model that used the baseline patient characteristics to predict the probability (propensity) of receiving off-pump procedure. Using a 1:1 ratio, we then matched on- and off-pump CABG patients based on the propensity of receiving off-pump procedure. We compared the Kaplan-Meier survival curves for on- and off-pump CABG using the matched data, and fit a Cox proportional hazards model to obtain the hazard ratio for death for off-pump in comparison to on-pump procedures. We also conducted subgroup analysis and tested the significances of interactions between treatment (on- or off-pump) and a number of baseline risk factors. Results: A total of 2,634 off-pump patients were matched to on-pump patients. During the follow-up until the end of 2007, 727 on-pump and 780 off-pump patients died. The respective 7-year survival rates for off- and on-pump were 71.3% and 73.1% (P=0.09), and the hazard ratio for death (off- vs. on-pump) was 1.11 (95% confidence interval: 1.00 to 1.24, P=0.06). In addition, there were no differences in 7-year mortality between off- and on-pump CABG surgery in the subgroups of patients defined by age, sex, the number of diseased coronary arteries, left main coronary disease, ejection fraction, history of myocardial infarction, and comorbidities such as cerebrovascular disease, peripheral vascular disease, congestive heart failure, and diabetes. Conclusions: There was no difference in long-term morality between on- and off-pump CABG surgery.
Abstract 19610: Nt-probnp for the Diagnosis of Paroxysmal Atrial Fibrillation in Patients With Ischemic Stroke - The Prospective Find-af Trial
Authors: Rolf Wachter, Rosine C Lahno, Beatrice Haase, Mark Weber-Kruger, Klaus Groschel, Raoul Stahrenberg
Journal: Circulation (2010)
Abstract 10527: LV Twist Mechanics in Acute Aortic Regurgitation; 2D Speckle Tracking Echocardiography Study in Canine Model
Authors: Sung-A Chang, Eun-Young Kim, Gye-Tak Ahn, Jeong-Ah Heo, Sung-Ji Park, Jin-Oh Choi, Sang-Chol Lee, Seung Woo Park, Eue-Seok Jeon, Jae K Oh
Journal: Circulation (2011)

Background: Acute aortic regurgitation (AR) is an urgent medical condition with acute change of volume and pressure load. Because of the mixed hemodynamic nature of AR, evaluation of left ventricul...
The symptoms of major depressive illness
Authors: J C Nelson, D S Charney
Journal: American Journal of Psychiatry (1981)

The authors suggest that the common characteristics of various descriptions of major depressive illness--endogenous, endogenomorphic, psychotic, and melancholic--are an autonomous course, a need for biological treatment, and a presumed alteration in neurochemistry. The literature is reviewed to determine those symptoms which best characterize this syndrome. These symptoms may prove useful in developing valid diagnostic criteria for major depressive illness.
Abstract 18401: P53 Silenced, Apoptosis Resistant, Endothelial Progenitor Stem Cells (EPC) Improve Collateral Circulation Post Femoral Artery Occlusion in Diabetic Mice
Authors: Mary Young, Cyril Chou, Sabyasachi Sen
Journal: Circulation (2012)

Literature shows that EPCs contribute to increased collateral vessel formation following vaso-occlusion. However diabetes reduces EPC number and reduces collateral vessel formation. We cultured human EPCs and exposed them to 5.5 mM (equivalent to 99mg%) and 20mM (equivalent to 360mg%, HG) glucose, which resulted in significant EPC death within 48hrs. We noted HG exposure was associated with up-regulation of P53 and its downstream genes such as P21, PUMA and Caspase-3. We hypothesized that EPC reduction in hyperglycemia is secondary to up-regulation of P53. We obtained mouse EPCs from P53 null mice and observed that p53 KO EPCs are more resistant to cell death in HG. P53 null EPCs evolved into mature mouse EC (MEC) and retained endothelial properties. Next, we used Lenti and Adenovirus mediated si-RNA methods to silence P53 (long and short term respectively) in human EPCs and P53 silenced EPc showed better survival in HG. We developed femoral artery occlusion model to mimic peripheral vascular disease in diabetic animals. We used streptozotocin induced type 1 diabetic or Leptin resistant type 2 diabetic mouse model. We delivered saline, P53 WT and P53 null mouse EPCs intra-muscularly around the femoral occlusion in these mouse models (n=7 in each group) and counted CD31+ve number of capillaries in a 20x microscopic field. Highest number was noted in the group that received P53null EPCs. We also quantified increased vessel formation by laser doppler assay of the ischemic and contralateral hind limbs upto 2 weeks and conducted qRT-PCR and western blot of key endothelial genes such as eNOS, p-eNOS, VEGF-A, PECAM-1 and vWF from both quadriceps in all groups of mice. Summary: Transplantation of P53 null EPCs in hyperglycemic mice with femoral occlusion demonstrate better collateral vessel formation post femoral artery occlusion setting compared to WT-EPC transplanted group. Preliminary results from transplantation of p53 silenced human CD34+ cells also indicate increased vessel formation compared to non p53 silenced hCD34+ cell in NOD-SCID diabetic mice. Conclusion: This finding indicates towards possible therapeutic benefit in transplanting P53 silenced human EPC or CD34+ cells to prevent peripheral vascular disease in patients with diabetes.
A Bi-Specific T Cell Engaging Monoclonal Antibody (mAb) Derived From a TCR-Like Mab Specific For WT1/HLA-A0201 (ESK-BiTE) Shows a Potent Activity Against Human AML and Ph+ ALL In Mouse Models
Authors: Dmitry Pankov, Tao Dao, Yiyang Wang, Andrew Scott, Tatyana Korontsvit, Victoria Zakhaleva, Nicholas Veomett, Michael Curcio, Ekaterina Doubrovina, Richard J. O'Reilly, Cheng Liu, David A. Scheinberg
Journal: Blood (2013)
Cluster of imported malaria from Gambia in Finland – travellers do not listen to given advice
Authors: K Valve, E Ruotsalainen, T Kärki, E Pekkanen, H Siikamäki
Journal: Eurosurveillance (2008)

Twelve Finnish tourists contracted falciparum malaria from Gambia in the period between 3 and 27 November 2008. None of them had used adequate malaria chemoprophylaxis.
Abstract 11851: CSL112, a Novel Formulation of Human Apolipoprotein A-I, Provides Sustained Increases in Biomarkers of Cholesterol Transport Following Repeat Dosing: A Placebo-Controlled, Randomized Multiple Ascending Dose Study in Healthy Subjects
Authors: Andreas Gille, Rachael Easton, Samuel Wright, Charles Shear
Journal: Circulation (2012)

Introduction: The ability of HDL to efflux cholesterol from atherosclerotic plaque is thought to underpin its potential for cardioprotection. CSL112 is apoA-I, the active component of HDL, purified...
Risk Factors for Stent Thrombosis After Implantation of Sirolimus-Eluting Stents in Diabetic and Nondiabetic Patients
Authors: Jacques Machecourt, Nicolas Danchin, Jean Marc Lablanche, Jean Marie Fauvel, Jean Louis Bonnet, Stephanie Marliere, Alison Foote, Jean Louis Quesada, Hélène Eltchaninoff, Gérald Vanzetto
Journal: Journal of the American College of Cardiology (2007)
Abstract 14566: Th17 Cells Exhibit Protective Effects Against Cardiac Fibrosis After Myocardial Infarction
Authors: Tomomi Yamashita, Masanori Obana, Akiko Hayama, Tomohiko Iwakura, Issei Komuro, Hiroyuki Nakayama, Yasushi Fujio
Journal: Circulation (2011)

Background: Cardiac inflammation is closely associated with heart failure; however, the molecular and cellular mechanisms of inflammatory reactions in myocardium remain to be fully elucidated. Inte...
Abstract 19505: Flecainide Increases AF Complexity by Enhancing Anisotropy in Goat Atria
Authors: Sander Verheule, Pranali Buch, Judith van Haare, Marion Kuiper, Arne van Hunnik, Ullrich Schotten
Journal: Circulation (2010)

Background: Despite its widespread clinical use for cardioversion of atrial fibrillation (AF), the mechanism by which flecainide (Flec) is able to restore sinus rhythm is still poorly understood. W...
Abstract 12968: Myocardial Perfusion Scintigraphy and Echocardiography for Detecting Coronary Artery Disease in Hypertensive Patients: A Meta-Analysis
Authors: Paola Gargiulo, Mario Petretta, Dario Bruzzese, Alberto Cuocolo, Maria Prastaro, Carmen D'Amore, Gianluigi Savarese, Enrico Vassallo, Caterina Marciano, Stefania Paolillo, Pasquale Perrone Filardi
Journal: Circulation (2011)
Early Relapse Of Follicular Lymphoma After R-CHOP Uniquely Defines Patients At High Risk For Death: An Analysis From The National Lymphocare Study
Authors: Carla Casulo, Michelle Byrtek, Keith L. Dawson, Xiaolei Zhou, Charles Farber, Christopher R. Flowers, John D. Hainsworth, Brian K Link, Andrew D. Zelenetz, Jonathan W. Friedberg
Journal: Blood (2013)
Thiamine transporter gene expression and exogenous thiamine modulate expression of genes in breast and lung cancers
Authors: Shuqian Liu, Arnold Stromberg, Hsin-Hsiung Tai, Jeffrey A. Moscow
Journal: Cancer Research (2004)

1378   Eukaryotic cells possess specific mechanisms for the uptake of water-soluble vitamins, including folate and thiamine. In previous studies we found that the RNA expression of the thiamine transporter THTR2 (SLC19A3) was down-regulated in breast and lung tumors in comparison to non-malignant surrounding tissue. To determine whether down-regulation of THTR2 expression may influence cancer progression, we analyzed gene expression in THTR2-transfected breast cancer cell line (MTXRZR75) compared to mock-transfected cells using a DNA microarray (Affymetrix). We found that cytochrome P450 isoform CYP4B1was 4-fold increased and 15-prostaglandin dehydrogenase (15-PGDH) was 2.7-fold increased in THTR2-transfected cells compared to control cells. Trefoil factor 1 (TFF1) was 2.6-fold decreased in THTR2-transfected cells. The microarray results were confirmed by quantitative RT PCR and western blot. To determine whether THTR2 expression had similar effects in other cell lines, we transfected THTR2 into MCF-7 and MDA-231 breast cancer cell lines. CYP4B1 RNA levels were 2.4-fold increased in THTR2-transfected MCF-7 cells compared to control cells. 15-PGDH RNA levels were 2.2-fold and 3.5-fold increased in transfected MCF-7 and MDA231cells, respectively. MDA231 cells did not have detectable expression of CYP4B1, so changes in its expression could not be measured. In addition, MDA231 cells also showed a 6.7-fold decrease in TFF1 gene expression after THTR2 transfection. To determine the role of exogenous thiamine in the expression of these three genes, we analyzed RNA levels of these genes in these cell lines by growing them in thiamine-depleted medium and demonstrated that two of three genes showed evidence of regulation by exogenous thiamine in the direction predicted by THTR2 transfection studies. CYP4B1was down-regulated by thiamine depletion and TFF1 was up-regulated by thiamine depletion. 15-PGDH RNA levels were not affected by thiamine depletion. Time-course studies of the effect of thiamine depletion and repletion on CYP4B1 and TFF1 show a gradual change in gene expression over an 8-day period. Since 15-PDGH and CYP4B1 are potentially involved in carcinogenesis, we determined whether there was evidence of coordinate regulation of these genes with THTR2 in lung tumors. These studies provide evidence that THTR2, 15-PGDH and CYP4B1 are all down-regulated in lung tumors in comparison to non-malignant surrounding tissue, and that TFF1 is up-regulated in lung tumors. In summary, these studies suggest potential links between thiamine metabolism and genes that may be involved in the oncogenesis of breast and lung cancer.
Abstract 3137: Failure of the Chromosome 9p21 Locus to Predict Myocardial Infarction when Non-Event Patients’ Coronary Disease Phenotype is Angiographically-Characterized
Authors: Benjamin D Horne, John F Carlquist, Joseph B Muhlestein, Tami L Bair, Jeffrey L Anderson
Journal: Circulation (2008)

A chromosome 9p21 locus is associated with coronary heart disease (CHD) phenotypes in at least 25 independent populations, but multiple clinically-distinct phenotypes have been evaluated. Utilizing angiographic coronary artery disease (CAD) phenotyping, this study evaluated whether 9p21 single nucleotide polymorphisms (SNPs) predict ischemic events (e.g., myocardial infarction [MI]) among CAD patients. Two populations of patients undergoing coronary angiography during 1994 –2007 (population 1: N=1,748; population 2: N=1,014) were evaluated for association of a 9p21 tagging SNP (rs2383206, A–&gt;G) with a composite MI/death endpoint vs. no event among patients with angiographically-significant CAD. Secondary analyses evaluated rs2383206 in two additional angiographic populations that included both CAD and non-CAD patients (population 3: N=2,122; population 4: N=1,466) for the phenotypes of MI vs. CAD/no MI, MI vs. no CAD, and CAD/no MI vs. no CAD. Post hoc analysis evaluated three other 9p21 SNPs. No association of rs2383206 was found with MI/death in populations 1 (OR=0.95 per G allele, p-trend=0.48) and 2 (OR=0.91 per G allele, p-trend=0.28), or with MI vs. CAD/no MI in populations 3 (OR=0.96 per G allele, p-trend=0.57) and 4 (OR=0.89 per G allele, p-trend=0.21). Among CAD patients, no association of rs2383206 was found with Duke CAD Index, number of significantly diseased vessels, left main disease, ostial disease, or proximal disease in the four populations. In contrast, rs2383206 was associated with CAD/no MI compared with no CAD (population 3: p-trend=0.0001; population 4: p-trend=0.0008). These findings were confirmed for rs2383207, rs10757274, and rs10757278. The chromosome 9p21 locus was not associated with MI or a composite of MI/death, or with extent or location of CAD, although it did predict CAD presence. This suggests that 9p21 is involved in the initiation or facilitation of CAD, not CAD progression or the precipitation of acute events. These findings contradict prior reports of a 9p21 association with MI, likely due to differences in study design and phenotype quality. High-quality angiographic phenotyping would be a useful standard in genetic association studies of CHD.
初级保健与结直肠癌即——使有全国性筛查，初级保健在降低死亡率方面仍大有可为
Authors: David, Weller, 邓瑞雪（译）
Journal: BMJ (2006)

在减少结直肠癌的公共卫生负担方面，初级保健机构具有坚实的作用。由于结直肠癌在诊断时随病情的进一步进展死亡率越高，而且大部分患者出现症状后会就诊于他们的全科执业医生，因此患者和医生都需要认识那些能预示肿瘤高风险的症状。本期中，du Toit及其同事报道了一项为期10年的前瞻性研究（见第273页），证实了直肠出血作为结直肠癌预警症状的重要性。此项研究发现大约十分之一的新发直肠出血患者有肿瘤。作者认为全科执业医生应对任何一位≥45岁的直肠出血患者进行检查，而无论其是否伴有排便习惯改变。
Abstract 2013: Predictors of Out-of-hospital Cardiac Arrest Survival: Influence of The Utstein Measures.
Authors: Thomas Rea, Andrea J Cook, Tom P Aufderheide, Tammy Beaudoin, Blair Bigham, Clif Callaway, Sumeet Chugh, Daniel Davis, Ahamed Idris, Laurie J Morrison, Graham Nichol, Judy L Powell, Ian G Stiell, Tom Terndrup, Venkatesh Thiruganasambandamoorthy, Lynn Wittwer
Journal: Circulation (2007)

Background The Utstein elements provide measures for comparing out-of-hospital cardiac arrest (OHCA) care and outcomes within and across communities. Whether these measures sufficiently predict survival and explain variation in outcome is not well studied. Hypotheses Utstein data elements predict survival to hospital discharge but explain only a portion of survival variation. Methods Design Prospective, population-based cohort using uniform data definitions. Setting Ten North American sites participating in the Resuscitation Outcomes Consortium, a prehospital emergency care network. Population Persons ≥ 20 years with OHCA from 12/1/2005 – 11/30/2006 (n=9582). Analyses We used logistic regression to assess association between Utstein elements and survival and to determine whether they accounted for site survival differences. We evaluated measures of residual variance to assess what proportion of outcome variation the Utstein elements predicted. Results Survival was 7.0% overall. Utstein elements were associated with survival (Table ). Relationships were similar when restricted to those with ventricular fibrillation. In analyses assessing variance of residuals, Utstein elements collectively accounted for 15% of variation in survival. Site was also associated with survival, ranging from 3.7% to 15.6%. In multivariable analyses, site association was not attenuated by adjusting for Utstein elements. Conclusion Although Utstein elements predict survival, they account for a modest portion of variation overall and do not explain survival differences across sites. Additional factors should be investigated to understand and potentially improve OHCA outcome.