ACETYL-DIGITOXIN (ACYLANID): RAPID DIGITALIZATION AND MAINTENANCE BY ORAL ADMINISTRATION
Authors: I C BRILL, P R BURGNER, N A DAVID
Journal: Annals of Internal Medicine (1956)

Article1 April 1956ACETYL-DIGITOXIN (ACYLANID): RAPID DIGITALIZATION AND MAINTENANCE BY ORAL ADMINISTRATIONISIDOR C. BRILL, M.D., F.A.C.P., PAUL R. BURGNER, M.D., NORMAN A. DAVID, M.D.ISIDOR C. BRILL, M.D., F.A.C.P.Search for more papers by this author, PAUL R. BURGNER, M.D.Search for more papers by this author, NORMAN A. DAVID, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-44-4-707 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptAcetyl-digitoxin2 is the most recently introduced cardiac glycoside undergoing clinical scrutiny. Chemically, it is unique in being the first pure crystalline glycoside produced by controlled enzymatic degradation of lanatoside A to remove only the single glucose molecule and leave intact the aglycone-3 digitoxoses-acetyl moiety.1 Experimentally, Rothlin et al.2 and Rothlin and Bircher3 demonstrated that acetyl-digitoxin is well absorbed from the intestinal tract, reduces the heart rate greatly and is less toxic than digitoxin.Clinically, it was reported by the European workers Loeffler, Essellier and Forster,4Trolliet et al.,5Hausler and Hortnagl6and Heinrich and Delius7that this new glycoside is...Bibliography1. StollKreis AW: Acetyl-digitoxin, Schweiz. med. Wchnschr. 83: 266 (Mar. 14) 1953. MedlineGoogle Scholar2. RothlinBircherSchalch ERWR: Zur Pharmakologie des Acetyl-digitoxin-a, Schweiz. med. Wchnschr. 83: 267 (Mar. 14) 1953. MedlineGoogle Scholar3. RothlinBircher ER: Pharmakodynamische Grundlagen der Therapie mit Herzwirksamen Glykosiden, Ergebn. d. inneren Med. und Kinderheilkunde 5: 457, 1954. MedlineGoogle Scholar4. LoefflerEssellierForster WAFG: Acetyl-digitoxin, ein neues Herzwirksames Glycosid. Klinisch-pharmakologische Untersuchungen, Schweiz. med. Wchnschr. 83: 290, 1953. MedlineGoogle Scholar5. TrollietConneDreyfuss JGR: Resultate therapeutiques obtenus avec l'acetyl-digitoxine-Sandoz, Praxis 42: 310 (Apr. 16) 1953. MedlineGoogle Scholar6. HauslerHortnagl HW: Klinisch-experimentelle Untersuchungen über die Herz- und Kreislaufwirksamkeit eines neuen Digitalis-Reinglykosides (Acetyl-digitoxin), Wien. klin. Wchnschr. 65: 473, 1953. MedlineGoogle Scholar7. HeinrichDelius KL: Klinische und katakritische Erfahrung mit der Digitoxin-Behandlung, Therap. Gegenw. 91: 284, 1952. MedlineGoogle Scholar8. LoefflerEssellierForster WAFG: Acetyl-digitoxin—clinical observations on the treatment of patients with advanced congestive heart failure, Am. Heart J. 6: 898 (June) 1954. Google Scholar9. ZilliLuisada AAA: Effects of acetyl-digitoxin in ambulatory patients with congestive failure, Exper. Med. and Surg. 13: 118-123 (June) 1955. MedlineGoogle Scholar10. HejtmancikHerrmann MRGR: Refractory congestive heart failure in the elderly patient, Texas State J. Med. 51: 238 (May) 1955. MedlineGoogle Scholar11. MaherPullen CCCW: Acetyl-digitoxin—a new cardiac glycoside, Rocky Mountain M. J. 52: 436 (May) 1955. MedlineGoogle Scholar12. CrouchHejtmancikHerrmann RBMRGR: A clinical evaluation of acetyl-digitoxin, Proceedings, 28th Scientific Sessions, American Heart Association, October 22-25, 1955, New Orleans, La. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Portland, Oregon*Received for publication December 2, 1955.From the Departments of Pharmacology and Medicine, University of Oregon Medical School, Portland, Oregon. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byTherapie der HerzinsuffizienzClinical evaluation of acetyl-digitoxinAcetyldigitoxin in the Treatment of Heart FailureDigitalis in Congestive Heart Failure 1 April 1956Volume 44, Issue 4Page: 707-716KeywordsArrhythmiaElectrocardiographyGlucoseGlycosidesHeart rateNauseaOral administrationPharmacology ePublished: 1 December 2008 Issue Published: 1 April 1956 PDF downloadLoading ...