tbuckley/cabot-search huggingface dataset:
Developmental Aspects of Immunity.
Authors: Robert A. Good
Journal: Annals of Internal Medicine (1972)

Meeting Abstracts1 May 1972Developmental Aspects of Immunity.Robert A. Good, M.D., Ph.D.Robert A. Good, M.D., Ph.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-76-5-853_5 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptStudies of immunological development in both ontogenetic and phylogenetic perspective supported and often guided by studies of patients with immunodeficiency have given much insight into the organization and function of the immunologic apparatus. Basically, the lymphoid system is organized into two interacting systems of lymphoid cells. One system develops under the differentiative influence of the thymus, the other in birds under the differentiative influence of the bursa of Fabricius. The thymusdependent system cells subserve the functions of cell-mediated immunities. These include delayed allergy; much of solid tissue allograft rejection capacity to initiate graft-versus-host reactions; and a major specific component in... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Minneapolis, Minn. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 May 1972Volume 76, Issue 5Page: 853-854KeywordsAllergy and immunologyCell mediated immunityCellsImmunityImmunodeficienciesLymphocytesThymus Issue Published: 1 May 1972 PDF DownloadLoading ...
Diffuse Colonic Polyposis Detected at Screening Colonoscopy: Mantle-Cell Lymphoma
Authors: H. Wolfsen, S. Achem
Journal: Endoscopy (2004)

Figure 1 A 63-year-old asymptomatic white man was referred for screening colonoscopy, which detected diffuse polyposis throughout the colon and terminal ileum. Subsequently, similar lesions in the duodenum were found on upper endoscopy. Diffuse abdominal lymphadenopathy and thickened mucosa in the terminal ileum were identified on computed tomography.
(26) A psoriasiform systematized epidermal naevus treated with isotretinoin
Authors: Julia A. Newton, M.M. Black
Journal: British Journal of Dermatology (1985)

Journal Article (26) A psoriasiform systematized epidermal naevus treated with isotretinoin Get access Julia A. Newton, Julia A. Newton ST Thomas' Hospital, London SE1 Search for other works by this author on: Oxford Academic Google Scholar M.M. Black M.M. Black ST Thomas' Hospital, London SE1 Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 113, Issue s29, 1 July 1985, Pages 69–70, https://doi.org/10.1111/j.1365-2133.1985.tb13041.x Published: 01 July 1985
Management of an esophageal metallic stent obstructed by tumor progression: endoscopic alcohol injection therapy instead of restenting
Authors: B. Ozdil, C. Kece, H. Akkiz, M. Sandikci, A. Cosar
Journal: Endoscopy (2010)

We report here a patient in whom an esophageal metallic stent was obstructed by tumor progression. The obstruction was treated successfully by endoscopic alcohol injection.
Reactions from the Use of Benzodioxane (933 F) in Diagnosis of Pheochromocytoma
Authors: Victor A. Drill
Journal: New England Journal of Medicine (1949)

PHEOCHROMOCYTOMA is a known cause of hypertension that is being more frequently diagnosed.1 This tumor produces epinephrine or an epinephrine-like substance that is responsible for the observed increase in blood pressure. Pharmacologically the dioxane group of drugs (883 F, 933 F, 1164 F and others) prevent or reverse the hypertension produced by epinephrine in animal experiments.2 , 3 The compounds 883 F and 933 F do not have any significant effect on the blood pressure of dogs or rats with renal hypertension.4, 5 Thus, the benzodioxane group of drugs would be expected to prevent the effects of circulating epinephrine produced by a pheochromocytoma, . . .
Ulcer Recurrence Following First Ray Amputation in Diabetic Patients
Authors: Luca Dalla Paola, Ezio Faglia, Maurizio Caminiti, Giacomo Clerici, Sasa Ninkovic, Valter Deanesi
Journal: Diabetes Care (2003)

To evaluate the reulceration and reamputation rates in a cohort of diabetic patients following first ray amputation.We evaluated a cohort of 89 diabetic patients, 63 men and 26 women, who underwent first ray amputation in the period from January 2000 to December 2001. The first ray lesions were Wagner grade 2 in 3 patients, Wagner grade 3 in 47 patients, and Wagner grade 4 in 39 patients. Following surgical wound healing, all patients wore special footwear with rocker bottom soles and custom molded insoles and were put on an intensive secondary prevention program.The mean follow-up duration was 16.35 +/- 6.76 months (range 7-28). Fifteen patients developed new ulcerations, with 11 lesions occurring ipsilaterally and 4 contralaterally to the first ray amputation. In seven patients, the new lesion was treated and healed with dressing. Eight patients underwent a new surgical procedure: panmetatarsal head resection in four patients, toe amputation in two patients, a transmetatarsal amputation in one patient, and Lisfranc's amputation in one patient.In the population studied, the first ray amputation presented a lower reulceration and reamputation rate with respect to that reported in the literature. This finding should therefore be attributed to the follow-up program, which uses shoes with a rocker bottom sole and custom molded insoles and intensive ambulatory check-ups.
Aiming at New Targets to Achieve Normoglycemia During Pregnancy
Authors: C. Andrew Combs, Robert G. Moses
Journal: Diabetes Care (2011)

In a recent issue of Diabetes Care , Hernandez et al. (1) from the University of Colorado presented a comprehensive review of the 24-h glucose profile during pregnancy in women without diabetes. In the current issue, Harmon et al. (2) from the same institution present new observations on the glycemic profile of pregnant nondiabetic women, examining differences between obese and normal-weight mothers and between different trimesters of pregnancy. Why are articles about women without diabetes being published in a journal whose very title declares that it is about the care of diabetes? The answer is that these two reports give us an idea of what is truly “normal” glucose during pregnancy, and this has important implications for the way we all manage diabetes during pregnancy. The articles are startling in that they both show that normal glucose values are substantially lower than the target values currently recommended for treatment of diabetes during pregnancy. Hernandez et al. (1) propose that we ought to change these targets to more closely approximate nondiabetic norms.

Contemporary management of diabetes during pregnancy is guided by the Pedersen Hypothesis, which holds that diabetic fetal macrosomia and various newborn metabolic sequelae are caused by endogenous fetal hyperinsulinemia, which is a response to fetal hyperglycemia. This, in turn, is a direct reflection of maternal hyperglycemia because glucose readily traverses the placenta whereas insulin does not (3). The corollary is that diabetic fetopathy should largely be preventable by preventing maternal hyperglycemia. The cornerstone of diabetes management in pregnancy, then, is to attempt to keep maternal glucose as close to normal as possible. But what exactly is a “normal” glucose during pregnancy? The articles by Hernandez et al. (1) and Harmon et al. (2) help us to answer this question.

The review by Hernandez et al. (1) reported on literature …
Pathology in Gynecology and Obstetrics
Authors: Robert E. Scully
Journal: JAMA (1970)

This volume, translated from an original French version, contains nine chapters on diseases of the female genital organs, including one on the breast and another on the placenta. There are no chapters specifically devoted to gynecologic cytology or abnormal sexual development, but these subjects are discussed briefly under other headings. The literature is cited extensively, with as many as 300 to 500 references listed after the longer chapters. About a third of the references are in foreign language. Most of the discussions are lucid, but some, particularly those dealing with controversial disorders, are indecisive and lack authority. The authors approach these subjects by presenting discordant opinions from the literature. Then they proceed to emphasize the lack of agreement rather than the acceptable knowledge. For example, the chapter on the ovary suggests that there may be no such entity as the Stein-Leventhal syndrome and that the classification of ovarian tumors is
Accuracy of pen injectors versus insulin syringes in children with type 1 diabetes.
Authors: A N Lteif, W F Schwenk
Journal: Diabetes Care (1999)

To compare the accuracy and precision of insulin syringes and pen devices used by children with type 1 diabetes and their parents.There were 48 subjects (32 patients, a parent of an additional 16 patients) instructed to measure out morning insulin doses three times from vials and/or cartridges containing saline mixed with small amounts of [14C]glucose (solution used as regular insulin) and [3H]glucose (solution used as NPH insulin) and to dispense the contents into a scintillation vial. Statistical analysis was used to determine the accuracy and precision of both methods of insulin delivery.The absolute error in measuring out doses of regular insulin < 5 U was greater with insulin syringes compared with pen injection devices (9.9 +/- 2.4 vs. 4.9 +/- 1.6%, respectively). Both were comparable for regular insulin doses > 5 U (3.2 +/- 0.6 vs. 2.2 +/- 0.4% for syringes and pens, respectively). The accuracy in drawing up NPH doses was similar for low and high insulin doses (mean percent error of 7.5 +/- 1.5 vs. 5.6 +/- 1.1%).Pen devices are more accurate than insulin syringes in measuring out insulin at low insulin doses. The accuracy of insulin syringes improves when higher doses of regular insulin are measured out and becomes comparable to pen devices.
RELATION OF EXERCISE OSCILLATORY VENTILATION TO CARDIAC REMODELING AND HEMOGLOBIN LEVEL IN PATIENTS WITH IDIOPATHIC DILATED CARDIOMYOPATHY
Authors: Takahiro Okumura, Akihiro Hirashiki, Yuji Kono, Jun Kojima, Satoru Ohshima, Kyosuke Takeshita, Xian Wu Cheng, Akiko Noda, Sumio Yamada, Toyoaki Murohara
Journal: Journal of the American College of Cardiology (2010)
Abstract 13444: G Protein-coupled Receptor Kinase-5 Attenuates Atherosclerosis by Desensitizing Monocyte/Macrophage Responses to Cytokines and by Enhancing Smooth Muscle Cell PDGF Receptor Ubiquitination
Authors: Alexander C Fanaroff, Lisheng Zhang, Jiao-Hui Wu, Karsten Peppel, Sabrina T Exum, Leigh Brian, Neil J Freedman
Journal: Circulation (2010)

G protein-coupled receptor kinase-5 (GRK5) is a Ser/Thr kinase that up-regulates in atherosclerotic arteries; it phosphorylates and desensitizes many receptors important to atherogenesis. We showed...
Abstract 1056: Deregulated HDAC9 expression in breast cancer is associated with basal molecular subtype
Authors: Aurélien Linares, Marion Lapierre, Abdel Boulahtouf, Carmen Rodriguez, Béatrice Orsetti, Patrick Balaguer, Thierry Maudelonde, Vincent Cavailles, Nathalie Boulle
Journal: Cancer Research (2012)

Abstract Estrogens play a pivotal role in the etiology of breast cancer. Estrogen receptor (ER) activity is finely regulated by various transcriptional regulatory complexes including histone acetyl transferases (HAT) and histone deacetylases (HDACs). Previous studies have underlined the potential role of some HDACs in breast tumor progression and their interactions with estrogen signalling. However, expression of the various class I, II and IV HDACs in breast tumors has not been systematically analysed. In this study, we performed a careful analysis of HDACs 1 to 11 expression in five breast cancer cell lines expressing (MCF7, ZR75, T47D) or not (MDA231, MDA436) ERα. HDAC4, HDAC11 and more strikingly HDAC9 were found to be differentially expressed in ERα+ and ERα- cells. HDAC9 mRNA levels were further measured in a panel of 14 breast tumor cell lines expressing or not ERα and classified as luminal, basal A and basal B. This showed that the difference in HDAC9 expression was more related to the luminal or basal characteristics of the breast tumor cells than to ERα expression, with basal cells harboring significantly higher HDAC9 mRNA levels than luminal ones. Comparison of mRNA levels of total HDAC9 with those of the longest HDAC9 isoforms (variants 1, 4 and 5) and the HDAC9ΔCD isoform, lacking the catalytic deacetylase domain (also known as MITR), showed a similar pattern of distribution among luminal, basal A and basal B cells. In basal cells, HDAC9 overexpression was not linked to gain in HDAC9 gene copy number but mainly to higher rates of gene transcription together with enhanced HDAC9 mRNA stability. Based on cDNA array data, the same differential expression was detected in patients’ tumors as significant higher levels of HDAC9 mRNA were measured in ERα negative and basal breast tumors as compared to ERα expressing and luminal ones respectively, suggesting the biological relevance of the results obtained using breast cancer cell lines. In contrast to luminal cells harboring very low or no detectable levels of HDAC9 protein, a 95 kDa HDAC9 protein isoform was detected in basal breast cancer cells, with a predominant and diffuse nuclear distribution as shown by immunofluorescence. Altogether, our results indicate that class IIa HDAC9 is overexpressed at the mRNA and protein levels in the most agressive breast tumors of basal phenotype. The role of this specific HDAC in breast carcinogenesis and ER signaling will be further analysed and described using mammary tumor cell models harboring HDAC9 overexpression or HDAC9 silencing. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 103rd Annual Meeting of the American Association for Cancer Research; 2012 Mar 31-Apr 4; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2012;72(8 Suppl):Abstract nr 1056. doi:1538-7445.AM2012-1056
Effects of Obstructive Sleep Apnea on Sleep Quality, Cognition, and Driving Performance in Patients With Cirrhosis
Authors: Jasmohan S. Bajaj, Leroy R. Thacker, David Leszczyszyn, Samuel A. Taylor, Douglas M. Heuman, Shekar Raman, Richard K. Sterling, Muhammad S. Siddiqui, R. Todd Stravitz, Arun J. Sanyal, Puneet Puri, Velimir Luketic, Scott Matherly, Michael Fuchs, Melanie B. White, Nicole A. Noble, Ariel B. Unser, James B. Wade
Journal: Clinical Gastroenterology and Hepatology (2014)
Persistent HIV antigenaemia and decline of HIV core antibodies associated with transition to AIDS.
Authors: J M Lange, D A Paul, H G Huisman, F de Wolf, H van den Berg, R A Coutinho, S A Danner, J van der Noordaa, J Goudsmit
Journal: BMJ (1986)

Sequential serum samples from 13 homosexual men who seroconverted for antibodies to human immunodeficiency virus (HIV) were tested for HIV antigen. In one of these men, who developed the acquired immune deficiency syndrome (AIDS), HIV antigenaemia preceded the onset of AIDS by more than a year and persisted throughout the course of the disease. This antigenaemia was accompanied by the disappearance of IgG antibody reactivity to the major HIV core protein p24. In none of the 12 others, who all remained without serious disease, were serum concentrations of HIV antigen detected, except on one occasion in one man. All their serum samples showed strong IgG antibody reactivity to p24. Nine children who were infected with HIV in 1981 by plasma transfusion from a single donor were also followed up for HIV antigenaemia. HIV antigen was almost constantly present in the serum (26 of 28 samples) of five children who developed AIDS related complex or AIDS and less often in the serum (four of 10 samples) of four children who remained free of symptoms. The two children who developed AIDS showed a virtual absence of antibody reactivity to p24. These results indicate that increased HIV gene expression is a contributing factor to the development of AIDS and also provide evidence for a switch from latent to active HIV infection.
Targeting Improves MSC Treatment of Inflammatory Bowel Disease
Authors: In Kap Ko, Byung-Gyu Kim, Amad Awadallah, Jenifer Mikulan, Paul Lin, John J Letterio, James E Dennis
Journal: Molecular Therapy (2010)

Inflammatory bowel disease (IBD), which includes Crohn's disease and ulcerative colitis, is an inflammatory autoimmune disease characterized by T-cell infiltration to the colon. Mesenchymal stem cells (MSCs) have the potential to rescue IBD owing to their immunosuppressive capabilities and clinical studies have shown positive influence on intestinal graft versus host disease. We demonstrate here a new method to coat MSCs with antibodies against addressins to enhance their delivery to the colon and thereby increase the therapeutic effectiveness. Bioluminescence imaging (BLI) demonstrated that vascular cell adhesion molecule antibody (Ab)-coated MSCs (AbVCAM-1- MSCs) had the highest delivery efficiency to inflamed mesenteric lymph node (MLN) and colon compared to untreated MSCs, Abisotype-MSCs, and AbMAdCAM-MSCs. Therapeutically, when mice with IBD were injected with addressin Ab-coated MSCs, they showed dramatically improved survival rates, higher IBD therapeutic scores, and significantly improved body weight gain compared to mice injected with MSCs only, isotype Ab, free Ab plus MSCs, or vehicle-only controls. These data demonstrate that anti-addressin Ab coating on MSC increased cell delivery to inflamed colon and increased the efficacy of MSC treatment of IBD. This is the first study showing an increased therapeutic efficacy when stem cells are first coated with antibodies specifically target them to inflamed sites. Inflammatory bowel disease (IBD), which includes Crohn's disease and ulcerative colitis, is an inflammatory autoimmune disease characterized by T-cell infiltration to the colon. Mesenchymal stem cells (MSCs) have the potential to rescue IBD owing to their immunosuppressive capabilities and clinical studies have shown positive influence on intestinal graft versus host disease. We demonstrate here a new method to coat MSCs with antibodies against addressins to enhance their delivery to the colon and thereby increase the therapeutic effectiveness. Bioluminescence imaging (BLI) demonstrated that vascular cell adhesion molecule antibody (Ab)-coated MSCs (AbVCAM-1- MSCs) had the highest delivery efficiency to inflamed mesenteric lymph node (MLN) and colon compared to untreated MSCs, Abisotype-MSCs, and AbMAdCAM-MSCs. Therapeutically, when mice with IBD were injected with addressin Ab-coated MSCs, they showed dramatically improved survival rates, higher IBD therapeutic scores, and significantly improved body weight gain compared to mice injected with MSCs only, isotype Ab, free Ab plus MSCs, or vehicle-only controls. These data demonstrate that anti-addressin Ab coating on MSC increased cell delivery to inflamed colon and increased the efficacy of MSC treatment of IBD. This is the first study showing an increased therapeutic efficacy when stem cells are first coated with antibodies specifically target them to inflamed sites.
Analyzing hospital mortality. The consequences of diversity in patient mix
Authors: J. Green
Journal: JAMA (1991)

Consumers and payers increasingly demand data with which to evaluate health care providers. While publication of risk-adjusted hospital-specific death rates is one response, debate continues over whether higher than predicted mortality is a warning about quality of care or rather a reflection of a hospital's atypical patient population. To help inform this debate, we compared the characteristics of Medicare patients discharged from 187 hospitals that the Health Care Financing Administration (HCFA) had labeled "high-mortality outliers" with those of Medicare patients from 5373 hospitals not so designated. Hospitals were most likely to be flagged as high-mortality outliers by HCFA when they had large shares of very elderly patients (age greater than or equal to 85 years), patients with high-risk diagnoses, or patients requiring nursing home care. After adjustments were made to compensate for these biases, nearly half the hospitals flagged as outliers by HCFA were no longer so designated. Statistics purporting to measure effectiveness of care from hospital death rates should be modified to account for diversity in patient mix.
368 REDUCED BONE MINERAL DENSITY DERIVED FROM DUAL X-RAY ABSORPTIOMETRY ASSESSMENTS IN PATIENTS WITH CHRONIC HEPATITIS B (CHB)
Authors: S. Fung, M. Fabri, F. Wong, J. Heathcoate, S. Gurel, W.C.P. Kwan, F.A. Caruntu, P. Husa, W. Mazur, M. Pelemis, E. Gane, D. Coombs, K.R. Hirsch
Journal: Journal of Hepatology (2011)
Inflammation: Basic Principles and Clinical Correlates
Authors: George E. Ehrlich
Journal: JAMA (1993)

This huge book bears testimony to an explosion of knowledge in a field of science that had, until the past quarter century, rested on five Galenic pillars (or Celsus' four, if one would have it simpler) of heat, redness, swelling, pain, and functional loss. The Big Bang took place so recently that most of the contents are barely known to clinicians, who will also find it difficult to swim through the alphabet soup of cytokines, growth factors, immunoglobulins, oxyradicals, adhesion molecules, prostanoids, complement, and other soluble and cellular components of inflammation. Yet this is the information that will help formulate the next generation of therapeutic interventions, better targeted than what we now have available, and thus the first 708 pages serve as a lexicon for reference. The material would be even more accessible if the distinguished array of authors had provided simplified summaries to set the stage for their chapters,
Further Assessment of Rosette Inhibition Test in Clinical Organ Transplantation
Authors: M. Bewick, C. S. Ogg, V. Parsons, S. A. Snowdon, L. Manuel
Journal: BMJ (1972)

The rosette inhibition test was used in the clinical management of organ allografts to estimate the amount of immunosuppressive drugs necessary to prevent rejection. In patients surviving more than three months renal function appeared to be better than in a similar group of patients managed without the test. It is suggested that this was due to a reduction in the number of clinical or subclinical rejection episodes. On the other hand, the test indicates that in many cases the level of immunosuppression should be much higher, and if this advice is followed the patients become increasingly exposed to the risk of infection. In other words, those patients with good renal function remained well, whereas those who might otherwise have rejected their kidney and survived had in fact died of sepsis.
TYPHUS FEVER
Authors: Henry Pinkerton
Journal: The Journal of Experimental Medicine (1931)

Study of two strains of epidemic (European) typhus and two strains of endemic (American) typhus in laboratory animals has shown their essential identity. .The characteristic typhus brain lesions can be shown to occur in all four strains after subcutaneous inoculation and Rickettsiae-filled cells can be found in the scrotal sac in all four strains after intraperitoneal inoculations. A strain of European typhus, which for 8 years has yielded no obvious scrotal reaction in guinea pigs, afterwards gave rise to a periodic scrotal reaction of variable severity. At present it occupies an intermediate position in this respect between the recently isolated European strain and the American strains. Variations in the scrotal reaction in guinea pigs appear to be correlated with strain variations in virulence in the human host. The incubation period in guinea pigs after intraperitoneal inoculation depends largely on the number of Rickettsiae injected.
Radixin deficiency causes conjugated hyperbilirubinemia with loss of Mrp2 from bile canalicular membranes
Authors: Shojiro Kikuchi, Masaki Hata, Kanehisa Fukumoto, Yukari Yamane, Takeshi Matsui, Atsushi Tamura, Shigenobu Yonemura, Hisakazu Yamagishi, Dietrich Keppler, Shoichiro Tsukita, Sachiko Tsukita
Journal: Nature Genetics (2002)