DERMATITIS DUE TO BARBITURATES: REPORT OF A CASE WITH ASSOCIATED ANEMIA
Authors: J. K. Potter, R. J. Whitacre
Journal: Annals of Internal Medicine (1944)

Case Reports1 December 1944DERMATITIS DUE TO BARBITURATES: REPORT OF A CASE WITH ASSOCIATED ANEMIAJ. K. POTTER, M.D., R. J. WHITACRE, M.D.J. K. POTTER, M.D.Search for more papers by this author, R. J. WHITACRE, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-21-6-1041 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe widespread use of barbiturates has resulted in numerous reports of reactions following their use. The type of reactions following ordinary doses of barbiturate is usually a form of dermatitis. Phenobarbital was introduced to the medical profession in 1911. A few months later Loewe1reported the first cutaneous reaction following the use of this drug. The skin manifestations were relatively mild and promptly disappeared upon withdrawal of the drug. Hamilton2reported the first case of universal exfoliative dermatitis due to phenobarbital in 1926. The majority of patients who have had skin reactions following the administration of barbiturates have recovered. However,...Bibliography1. LOEWE S: Klinische Erfahrungen mit Luminal, Deutsch. med. Wchnschr., 1912, xlii, 947. CrossrefGoogle Scholar2. HAMILTONGEIGERROTH ESCWJH: Luminal poisoning with conjunctival residue, Illinois Med. Jr., 1926, xlix, 344. Google Scholar3. CHAVANYVANNIER JAPE: Toxidermie barbiturique à type d'érythème scarlatiniforme infiltré, Progrès Méd., 1929, xliv, 1685. Google Scholar4. WILEBENSON UJJA: Exfoliative dermatitis due to phenobarbital with fatal outcome: report of 2 cases, Ann. Int. Med., 1940, xiii, 1243. Google Scholar5. SEXTONPIKENIELSON DLGMA: Exfoliative dermatitis and death due to phenobarbital, Jr. Am. Med. Assoc., 1941, cxvi, 700. CrossrefGoogle Scholar6. WINERBAER NJRL: Exfoliative dermatitis due to phenobarbital, Arch. Dermat. and Syph., 1941, xliii, 473. CrossrefGoogle Scholar7. SCHULTE TL: Tissue changes in chronic intoxication of barbital, California and West. Med., 1939, l, 256. Google Scholar8. ROTH GB: The barbiturates and some of their side-effects, Med. Ann. Dist. Columbia, 1942, xi, 254. Google Scholar9. MENNINGER WC: Skin eruptions with phenobarbital (luminal), Jr. Am. Med. Assoc., 1928, xci, 14. CrossrefGoogle Scholar10. SCARLETTMACNAB EPDS: Poisoning from phenobarbital (luminal), Canad. Med. Assoc. Jr., 1935, xxxiii, 635. Google Scholar11. POOLE AK: Drug reactions from barbital (veronal) and phenobarbital (luminal), Yale Jr. Biol. and Med., 1929, i, 345. Google Scholar12. HUDDLESTON JH: Non-dermatological disturbances during continued treatment with phenobarbital, Jr. Am. Med. Assoc., 1929, xciii, 1637. Google Scholar13. TAYLORSCHRAM HWM: Phenobarbital poisoning, Arch. Pediat., 1936, liii, 670. Google Scholar14. DIETRICH HF: Sodium propyl-methyl-carbinyl allyl barbiturate (Seconal) as a sedative for infants and children: A clinical evaluation of one of the newer barbiturates, Anes. and Analg., 1943, xxii, 28. Google Scholar15. NOVY FG: Drug eruptions due to the barbiturates, California and West. Med., 1938, xlviii, 324. Google Scholar16. STRYKER GV: Barbituric acid dermatitis with photosensitization, Jr. Med., 1940, xx, 516. Google Scholar17. MOSSLONG REWE: Toxic eruptions due to phenobarbital: report of two cases, Arch. Dermat. and Syph., 1942, xlvi, 386. CrossrefGoogle Scholar18. BETHEA OW: The barbituric acid salts, Internat. Med. Digest, 1932, xxi, 371. Google Scholar19. WISESULZBERGER FM: Drug eruptions: I. Fixed Phenolphthalein eruptions, Arch. Dermat. and Syph., 1933, xxvii, 549. CrossrefGoogle Scholar20. HILL BP: Hypersusceptibility to basal anesthetics, Brit. Med. Jr., 1938, ii, 1199. CrossrefGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: *Received for publication April 16, 1943. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byDRUG REACTIONS XVII.Clinical Re-evaluation of Daytime Sedatives 1 December 1944Volume 21, Issue 6Page: 1041-1044KeywordsAnemiaDrugsSkin reaction ePublished: 1 December 2008 Issue Published: 1 December 1944 PDF downloadLoading ...