Hypocalcemia and Osteomalacia Associated with Anticonvulsant Therapy
Authors: BOY FRAME
Journal: Annals of Internal Medicine (1971)

Editorial Notes1 February 1971Hypocalcemia and Osteomalacia Associated with Anticonvulsant TherapyBOY FRAME, M.D., F.A.C.P.BOY FRAME, M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-74-2-294 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptIt is commonly known that hypocalcemia can cause a variety of epileptic seizure patterns. That anticonvulsants used in the therapy of epilepsy can diminish the signs of tetany and tetanic equivalents in patients with hypocalcemia is less commonly recognized (1). Thus hypocalcemia may be overlooked as a cause of epilepsy if anticonvulsants are inadvertently administered for hypocalcemic convulsions. Recent reports from Europe now suggest that long-term anticonvulsant therapy may also initiate serum chemical and histologic changes of osteomalacia. These new observations can be logically accounted for by new findings in vitamin D metabolism.In 1968 Kruse reported that 15% of...References1. SCHAFFPAYNE MC: Effect of diphenylhydantoin and phenobarbital on overt and latent tetany. New Eng J Med 274:1228-1233, 1966 CrossrefMedlineGoogle Scholar2. KRUSE R: Osteopathien bei antiepileptischer Langzeittherapie (vorlaufige Mitteilung). Mschr Kinderheilk 116:378-381, 1968 MedlineGoogle Scholar3. RICHENSROWE AD: Disturbance of calcium metabolism by anticonvulsant drugs. Brit Med J 4:73-76, 1970 CrossrefMedlineGoogle Scholar4. TOMAN J: Drugs effective in convulsive disorders, in Pharmacologic Basis of Therapeutics, edited by GOODMAN LS, GILLMAN H. New York, The Macmillan Co., pp. 215-236 Google Scholar5. DENTRICHENSROWE CAD: Osteomalacia with long-term anticonvulsant therapy in epilepsy. Brit Med J 4:69-72, 1970 CrossrefMedlineGoogle Scholar6. DELUCA H: Current concepts, vitamin D. New Eng J Med 281:1103-1104, 1969 CrossrefMedlineGoogle Scholar7. KUNTZMAN R: Drugs and enzyme induction. Ann Rev Pharmacol 9:21, 1969 CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Department of Medicine Henry Ford Hospital Detriot, Mich. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByOstéomalaciesOsteomalaciaBone mineral density, vitamin D and anticonvulsant therapyAntiepileptic DrugsDiphenylhydantoin Effects in HypocalcemiaJOSHUA TRABULUS, B.A., PAUL O. GULSRUD, M.D., INDER J. CHOPRA, M.D., F.A.C.P.Serum alkaline phosphatase and urinary hydroxyproline values in children receiving phenobarbital with and without vitamin DEndocrine manifestations of diphenylhydantoin therapyCalcium Metabolism in Elderly Epileptic Patients during Anticonvulsant TherapyVitamin D-dependent rickets in institutionalized, mentally retarded children receiving long-term anticonvulsant therapy. I. A survey of 288 patientsRadiologic Bone Changes and Hypocalcemia with Anticonvulsant Therapy in EpilepsyEERO A. SOTANIEMI, M.D., HEIKKI K. HAKKARAINEN, M.D., JAAKO A. PURANEN, M.D., REIJO O. LAHTI, M.D. 1 February 1971Volume 74, Issue 2Page: 294-295KeywordsAnticonvulsantsConvulsionsEpilepsyEpileptic seizuresHypocalcemiaVitamin D Issue Published: 1 February 1971 PDF DownloadLoading ...