THE DIAGNOSTIC VALUE OF REGRESSION OF SECONDARY SEXUAL CHARACTERISTICS IN CASES OF HEMOCHROMATOSIS
Authors: Edwin J. Kepler, Donald R. Nichols, John H. Mills
Journal: Annals of Internal Medicine (1940)

Article1 November 1940THE DIAGNOSTIC VALUE OF REGRESSION OF SECONDARY SEXUAL CHARACTERISTICS IN CASES OF HEMOCHROMATOSISEDWIN J. KEPLER, M.D., F.A.C.P., DONALD R. NICHOLS, M.D., JOHN H. MILLS, M.D., F.A.C.P.EDWIN J. KEPLER, M.D., F.A.C.P.Search for more papers by this author, DONALD R. NICHOLS, M.D.Search for more papers by this author, JOHN H. MILLS, M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-14-5-810 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptCase reports of hemochromatosis associated with regression of the secondary sexual characteristics have appeared in the literature sporadically.1, 2, 3, 4It is not generally appreciated, however, that these findings may appear relatively early in the course of the disease and, therefore, give a clue to the diagnosis before bronzing of the skin, enlargement of the liver, and diabetes become diagnostically manifest. The two cases herein reported are illustrative. The first case was studied before we were aware of the fact that signs of hypogonadism or anterior pituitary insufficiency occurred in conjunction with hemochromatosis. As there was comparatively little pigmentation...References1. ALTHAUSENKERR TLWJ: Hemochromatosis. A report of three cases with results of insulin therapy in one case, Endocrinology, 1927, xi, 377-442. CrossrefGoogle Scholar2. ALTHAUSENKERR TLWJ: Hemochromatosis. II. A report of three cases with endocrine disturbances and notes on a previously reported case. Discussion of etiology, Endocrinology, 1933, xvii, 621-646. CrossrefGoogle Scholar3. DARNALL JR: Hemochromatosis: Review of the literature and report of three cases, ANN. INT. MED, 1935, viii, 1121-1137. Google Scholar4. LABBEBOULINUHRY MRP: Diabète bronzé avec atrophie des organes génitaux et chute des poils [Syndrome hépato-pancréato-génital], Bull, et mém. Soc. méd. d. hôp. de Paris, 1934, xl, 1574-1576. Google Scholar5. HURXTHAL LM: Hemochromatosis as a cause of renal and suprarenal failure: a case report, Lahey Clinic Bull., 1938, i, 9-13. Google Scholar6. SHELDON JH: Haemochromatosis, 1935, Oxford University Press, London. Google Scholar7. BUTTWILDER HRRM: Hemochromatosis: report of thirty cases in which the diagnosis was made during life, Arch. Path., 1938, xxvi, 262-273. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Rochester, Minnesota*Received for publication May 9, 1940.†Now residing in Chicago, Illinois.‡ Possibly the pigmentation would have been more noticeable had he not been occupying a room with an individual who was intensely pigmented and who was suspected of having but did not have, hemochromatosis. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byPHLEBOTOMY FOR HÆMOCHROMATOSIS EFFECT OF REMOVING 52 PINTS OF BLOOD IN SIXTEEN MONTHSTHE COURSE OF ANTERIOR HYPOPITUITARISM 1 November 1940Volume 14, Issue 5Page: 810-816KeywordsHemochromatosisHypogonadismLiverLiver diseases ePublished: 1 December 2008 Issue Published: 1 November 1940 PDF downloadLoading ...