tbuckley/cabot-search huggingface dataset:
H‐Chain Ferritin: A Natural Nuclei Targeting and Bioactive Delivery Nanovector
Authors: Lianbing Zhang, Le Li, Alessandra Di Penta, Unai Carmona, Fan Yang, Regina Schöps, Matthias Brandsch, José L. Zugaza, Mato Knez
Journal: Advanced Healthcare Materials (2015)

Nuclear translocation of human H-chain in its intact cage-like structure without any additional modifications enables a rapid nuclear delivery of an encapsulated anticancer drug (doxorubicin). This reduces the doses of drugs simultaneously bypassing the cellular multidrug resistance. Apoferritin exhibits synergistic effects through attenuating drug-induced dysregulation of the cellular iron. Tests on cerebellar organotypic cultures show the natural cell selectivity and drug accumulation in brain tissue. As a service to our authors and readers, this journal provides supporting information supplied by the authors. Such materials are peer reviewed and may be re-organized for online delivery, but are not copy-edited or typeset. Technical support issues arising from supporting information (other than missing files) should be addressed to the authors. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
Bacterial Lipopolysaccharides as Helper Factors for Friend Spleen Focus-Forming Virus in Mice 2
Authors: Richard A. Steeves, Inge Grundke Iqbal
Journal: JNCI Journal of the National Cancer Institute (1976)

Journal Article Bacterial Lipopolysaccharides as Helper Factors for Friend Spleen Focus-Forming Virus in Mice Get access Richard A. Steeves, Richard A. Steeves 3Department of Developmental Biology and Cancer, Albert Einstein College of Medicine, Bronx, N.Y. 10461. Search for other works by this author on: Oxford Academic PubMed Google Scholar Inge Grundke Iqbal Inge Grundke Iqbal 4Department of Cell Biology, Albert Einstein College of Medicine. 5We are grateful for materials and/or advice provided by several colleagues: Drs. O. Liideritz and E. Rietschel, Max-Planck-Institut für Immunobiologie, Freiburg, Federal Republic of Germany, for samples of purified lipopolysaccharide: Drs. F. Lilly and S. Shin, Department of Genetics, Albert Einstein College of Medicine, for providing special types of inbred mice; Dr. T. Pincus, Memorial Sloan-Kettering Cancer Center, New York, N.Y., for help with the XC assay; Dr. E. Hanna, Laboratory of Molecular Genetics, National Institute of Child Health and Human Development, Bethesda, Md., Dr. R. Levy, Department of Immunopathology, Scripps Clinic and Research Foundation, La Jolla, Calif., and Dr. D. Summers, Department of Microbiology, University of Utah, Salt Lake City, Utah, for providing helpful ideas and suggestions. Technical assistance by Mr. V. Grant, Mr. P. Roe. and Ms. P. Louis is also acknowledged. Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 56, Issue 3, March 1976, Pages 541–546, https://doi.org/10.1093/jnci/56.3.541 Published: 01 March 1976 Article history Received: 19 June 1975 Accepted: 03 October 1975 Published: 01 March 1976
Integration of COPD management across primary and secondary care: Feasibility and impact
Authors: Patrick White, Craig Davidson, Noel Baxter, Lauren Hogg, Jacqui Fenton, Jack Barker, Paul Seed, Hannah Thornton
Journal: European Respiratory Journal (2011)

Introduction:  Integration of COPD treatment across primary and secondary care aims to maximize resources, reduce waste, and optimize care. We evaluated a service innovation in COPD across two hospitals and two primary care trusts (PCTs) between 2008 and 2011.   Method:  Five enhanced services: hospital-based admission-response; integrated pulmonary rehabilitation (PR); intermediate care COPD service; bespoke electronic COPD clinical record; 24/7 emergency telephone support service. The evaluation used routinely collected data to assess COPD admissions, primary care COPD prescribing, contacts in the new services, interventions and outcomes in the intermediate care service, and impact of 24/7 telephone support, and compared outcomes to two adjacent PCTs.   Results:  6068 patients with COPD were identified in a population of 511,000 served by 98 practices. 2308 (38%) patients were referred to PR, an increase of 35%. 1100 patients were seen by the admission response service, 1230 in the intermediate care service, and 453 were registered to use the 24/7 emergency telephone line. Average admissions were 980/year, stable during the project, and did not differ from admissions in 2.75 years before the project. Steady increase in prescribing of tiotropium and of inhaled combination long-acting bronchodilators and corticosteroids. No differences in numbers of COPD admissions or prescribing rates compared to two adjacent PCTs over the same period. No differences in admissions compared to 29 London PCTs   Conclusions:  No impact of integrated COPD care was seen despite substantial numbers of patients and practices taking part. Rising prescriptions of COPD drugs were not reflected in a fall in admissions.
Host microbiota constantly control maturation and function of microglia in the CNS
Authors: Daniel Erny, Anna Lena Hrabě de Angelis, Diego Jaitin, Peter Wieghofer, Ori Staszewski, Eyal David, Hadas Keren-Shaul, Tanel Mahlakoiv, Kristin Jakobshagen, Thorsten Buch, Vera Schwierzeck, Olaf Utermöhlen, Eunyoung Chun, Wendy S Garrett, Kathy D McCoy, Andreas Diefenbach, Peter Staeheli, Bärbel Stecher, Ido Amit, Marco Prinz
Journal: Nature Neuroscience (2015)
Health and human rights
Authors: J. Leaning
Journal: BMJ (2001)

In 1986 and 1992 the BMA broke new ground in publishing reports on human rights that documented what physicians were doing to the detriment of their patients and profession and identified ways in which medical associations could help constrain such behaviour. 1 2 The definition of human rights remained relatively restricted, however, in concentrating on rights in closed institutions such as prisons and psychiatric hospitals. In its latest book, The Medical Profession and Human Rights: A Handbook for a Changing Agenda ,3 published last month, the BMA has set its sights on a much wider range of issues and a wider audience—all mainstream physicians and healthcare professionals in Europe and North America.

Certainly, much of relevance to human rights has happened in the past decade, including wars in the former Yugoslavia, Rwanda, and Chechnya; trials and truth and reconciliation processes; the development of the Istanbul Protocol on physicians and torture; and civil campaigns to ban landmines and establish an international criminal court. As a result of these experiences a small segment of the medical community is growing knowledgable about dealing with health and human rights issues of psychological trauma, 4 5 cultural and religious clashes on health practices,6 the complicity of physicians in repressive regimes,7 investigations into mass killings and terror,8 and the medical arguments against certain weapons systems.9 The BMA could have recounted the lessons …
Abstract 18749: CD34+ Circulating Progenitor Cell Levels for Prediction of Subclinical Atherosclerotic Disease
Authors: Joao Pedro Lopes, David Zidar, Masakazu Ishikawa, Mohamad Alaiti, Bruno Nascimento, Antonio Luiz Ribeiro, Jose Luiz Padilha, Yunmei Wang, Mukesh Jain, Daniel Simon, Marco Costa
Journal: Circulation (2014)

Introduction: The public health burden of atherosclerosis remains unacceptably high despite existing measures aimed at primary prevention. Although the detection of subclinical atherosclerotic disease as measured by quantification of coronary artery calcium score (CACS) by computed tomography (CT) refines risk estimation, this approach is costly and may not be feasible as a global strategy. We sought to analyze peripheral blood mononuclear cells (PB-MNC) using polychromatic flow cytometry in patients undergoing cardiac CT to determine cellular correlates of early atherosclerosis. Methods: We enrolled 286 patients with recent CT for CACS determination (125 CACS=0 / 161 CACS&gt;0). PB-MNCs were isolated for flow cytometry determination using a panel of cell markers, to quantify CD34+CD45dim circulating progenitor cells (CPC). We performed multivariable logistic regression analysis to identify independent predictors of CACS=0. Integer chance weights were assigned to each independent risk variable as a point scoring system. Summed scores were used to define chance groups in quartiles. Predicted chances of CACS=0 were compared with the observed chances and a score calibration test (Hosmer-Lemeshow) was performed. Results: High levels of circulating CPC independently predicted the absence of subclinical atherosclerosis in addition to age, female gender, and nonsmoking status. A risk score calibration test demonstrated the predicted and observed chances of this outcome were similar by risk group (p &gt; 0.05). The area under the ROC for the model indicates a 78% chance that the model assigned a lower probability to a patient with CACS=0 than to a patient with subclinical atherosclerosis. Conclusion: In our sample, the proportion of CPC was shown to be an independent predictor of absence of coronary disease and the generated score showed a robust correlation between predicted and observed values of CACS.
Health Industry Practices That Create Conflicts of Interest
Authors: Troyen A. Brennan, David J. Rothman, Linda Blank, David Blumenthal, Susan C. Chimonas, Jordan J. Cohen, Janlori Goldman, Jerome P. Kassirer, Harry Kimball, James Naughton, Neil Smelser
Journal: JAMA (2006)

Conflicts of interest between physicians' commitment to patient care and the desire of pharmaceutical companies and their representatives to sell their products pose challenges to the principles of medical professionalism. These conflicts occur when physicians have motives or are in situations for which reasonable observers could conclude that the moral requirements of the physician's roles are or will be compromised. Although physician groups, the manufacturers, and the federal government have instituted self-regulation of marketing, research in the psychology and social science of gift receipt and giving indicates that current controls will not satisfactorily protect the interests of patients. More stringent regulation is necessary, including the elimination or modification of common practices related to small gifts, pharmaceutical samples, continuing medical education, funds for physician travel, speakers bureaus, ghostwriting, and consulting and research contracts. We propose a policy under which academic medical centers would take the lead in eliminating the conflicts of interest that still characterize the relationship between physicians and the health care industry.
THE USE OF HISTAMINE IN RHEUMATOID ARTHRITIS
Authors: R. O. Muether
Journal: Annals of Internal Medicine (1940)

ExcerptThere can be little doubt that arthritis and allied conditions are assuming a deservedly more important place in the thoughts of both the clinician and the research worker. In spite of much recent work, however, a satisfactory basis for treatment has not been established, and some treatments are expensive and complicated. Fever therapy, hydrotherapy, etc., seem to give great relief but are difficult of attainment under ordinary circumstances. The production of artificial jaundice advocated by Hench is difficult to obtain because of its dangers and expense.1, 2, 3, 4It is true that certain forms of physical therapy can be...
Reliability of league tables of in vitro fertilisation clinics: retrospective analysis of live birth rates Commentary: How robust are rankings? The implications of confidence intervals
Authors: E C. Marshall, D. J Spiegelhalter, C. Sanderson, M. McKee
Journal: BMJ (1998)

<h3>Abstract</h3> <b>Objective:</b> To determine to what extent institutions carrying out in vitro fertilisation can reasonably be ranked according to their live birth rates. <b>Design:</b> Retrospective analysis of prospectively collected data on live birth rate after in vitro fertilisation. <b>Setting:</b> 52 clinics in the United Kingdom carrying out in vitro fertilisation over the period April 1994 to March 1995. <b>Main outcome measure:</b> Estimated adjusted live birth rate for each clinic; their rank and its associated uncertainty. <b>Results:</b> There were substantial and significant differences between the live birth rates of the clinics. There was great uncertainty, however, concerning the true ranks, particularly for the smaller clinics. Only one clinic could be confidently ranked in the bottom quarter according to this measure of performance. Many centres had substantial changes in rank between years, even though their live birth rate did not change significantly. <b>Conclusions:</b> Even when there are substantial differences between institutions, ranks are extremely unreliable statistical summaries of performance and change in performance, particularly for smaller institutions. Any performance indicator should always be associated with a measure of sampling variability. <h3>Key messages</h3> Institutional ranks are extremely unreliable statistical summaries of performance Institutions with smaller numbers of cases may be unjustifiably penalised or credited in comparison exercises Additional statistical analysis may help to identify the few institutions worthy of review Any performance indicator should always have an associated statistical sampling variability
Randomized controlled trial of primary prevention of atopy using house dust mite allergen oral immunotherapy in early childhood
Authors: Zaraquiza Zolkipli, Graham Roberts, Victoria Cornelius, Bernie Clayton, Sarah Pearson, Louise Michaelis, Ratko Djukanovic, Ramesh Kurukulaaratchy, S. Hasan Arshad
Journal: Journal of Allergy and Clinical Immunology (2015)
New Initiatives Target Inmates' Health
Authors: Rebecca Voelker
Journal: JAMA (2004)

A LITTLE MORE THAN 5 YEARS AGO, Michael Kelley, MD, decided he wanted to be where the action is. That decision landed him in prison, but he has no regrets. As director of preventive medicine for the Texas Department of Criminal Justice, Kelley believes he can make more of a difference in public health than in his previous work with the Texas Department of Health. “It is exciting . . . I really like what I’m doing,” he says. The state prison system “has a highrisk population, a high burden of disease, a more controlled environment, and a structured health care system.” In other words, it is a place where an individual physician can have an unusual degree of leverage to improve the system. Throughout the years, the image of the “jail doc” and health care conditions in correctional facilities has bordered on appalling. And even though inmate advocates say many US prisons and jails continue to have “shocking” health care problems, another picture of correctional health care is beginning to emerge. The field is maturing, as physicians like Kelley find new challenges and the National Commission on Correctional Health Care (NCCHC) and other groups work to establish comprehensive surveillance systems, screening programs, and the use of clinical guidelines in correctional settings. Some correctional physicians predict that the day when prisons and jails produce outcomes comparable with commercial health plans isn’t far off. “We now have a much better sense of what is necessary to provide adequate care [in correctional settings] by using nationally recognized guidelines and keeping up with science,” says Ronald Shansky, MD, MPH, a Chicagobased correctional health consultant.
Abstract 19314: Impact of Body Mass Index on Clinical Outcomes in Complex Adult Congenital Heart Disease
Authors: Norihisa Toh, Ines Uribe Morales, Zakariya Albinmousa, Tariq Saifullah, Rachael Hatton, Krishnakumar Nair, Rachel Wald, S. Lucy Roche
Journal: Circulation (2014)

Background: Obesity can adversely affect most organ systems and increases the risk of comorbidities likely to be of consequence for patients with complex adult congenital heart disease (ACHD). Conversely, several studies have demonstrated that low body mass index (BMI) is a risk factor for heart failure and adverse outcomes after cardiac surgery. However, there are currently no data regarding the impact of BMI in ACHD. Methods: We examined the charts of 87 randomly selected, complex ACHD patients whose first visit to our institution was at 18-22 years old. Patients were categorized according to BMI at initial visit: underweight (BMI &lt; 18.5 kg/m 2 ), normal (BMI 18.5 - 24.9 kg/m 2 ), overweight/obese (BMI ≥ 25 kg/m 2 ). Events occurring during follow-up were recorded. Data was censured on 1/1/2014. Cardiac events were defined as a composite of cardiac death, heart transplantation or admission for heart failure. Results: The cohort included patients with the following diagnoses: tetralogy of Fallot n=31, Mustard n=28, Fontan n=17, ccTGA n=9 and aortic coarctation n=2. The median (IQR) duration of follow-up was 8.7 (4.2 - 1.8) years. See table for distribution and outcomes by BMI category. Cardiac events occurred in 17/87 patients. After adjustment for age, sex, and underlying disease, the underweight group had increased risk of cardiac events (HR=12.9, 95% CI: 2.8-61.5, p &lt; 0.05). Kaplan-Meier curves demonstrate the poorer prognosis of underweight patients (Figure). Conclusions: Underweight was associated with increased risk of late cardiac events in ACHD patients. We were unable to demonstrate significant overweight/obesity impact.
Lawrence ("Lar") Healy John Bateman Lawson Philip Marsden Michael Kenneth Mead
Authors: R. Deignan, A E Fye, A. Bryceson, M. Ward
Journal: BMJ (1998)

# Lawrence (“Lar”) Healy {#article-title-2}

   ![][1] 

General practitioner Limekilns, Fife, 1988-97 ( b 1961; q Royal College of Surgeons in Ireland 1985; MRCGP), died of a cervical chordoma on 7 October 1997. He came from a distinguished family: his father is a consultant pathologist, his grandfather was master of the Coombe Hospital, Dublin, and his great grandfather was the first governor general of Ireland. After house jobs he and his wife did voluntary jobs in Peru, before going for general practice training to Limekilns, where he became a partner in 1990. With his humanity and ability to relate to people, he was an integral part of the local community, and he lived his life with vigour and enthusiasm. Golf was the chief of his many sporting interests, but he loved wine and travel and supplemented his salary at a weekly card school. He leaves a wife, Jane, and three sons.

# John Bateman Lawson {#article-title-3}

   ![][2] 

Professor of obstetrics and gynaecology Ibadan, Nigeria, and Newcastle upon Tyne 1953-87 ( b Ashby de la Zouch 1922; q Cambridge/The London 1945; FRCOG), died …

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The batch‐to‐batch variation of the potency of dog– and cat–allergen‐coated lancets
Authors: S. Dreborg
Journal: Allergy (1993)

In clinical work I formed the impression that the potency of Phazet lancets, for cat and dog allergens, was lower than earlier and too low to diagnose all clinically sensitive children with cat and dog allergy. Therefore, I decided to investigate the potency of newly produced and several years old Phazet lancets coated with dog and cat allergens. Twenty-six adults with case histories of cat and/or dog allergy and skin reactive to extracts of either dog dander or cat epithelium were skin prick tested in duplicate with one old batch and one newly produced batch of Phazet dog and/or cat lancets as well as the in-house reference of cat and/or dog allergen, 100,000 BU/ml. The potency of Phazet lancets in relation to the standard was evaluated by the median slope of the allergen dose-response relationship. The potency of the old dog lancets (mean 48,900 BU/ml) was higher (NS) than that of the newly produced lancets (mean 28,000 BU/ml), and the potency of both types of lancets was significantly less (P < 0.001) than that of the dog allergen in-house standard. On the other hand, the potency of newly produced (123,000 BU/ml), but not old (108,000), cat-allergen-coated Phazet lancets was higher than that of the cat allergen in-house reference extract (P = 0.048). There was a marked variation in potency between patients. Most of this variation was due to factors varying between patients, not between lancets, indicating that the composition of the allergen on the lancets was partly different from that of the standard.(ABSTRACT TRUNCATED AT 250 WORDS)
Sensitive Detection of FIP1L1-PDGFRA Fusion Transcripts by Real-Time Quantitative RT-PCR (RQ-PCR) Reveals Achievement of Molecular Remission in Chronic Eosinophilic Leukemia Treated with Low-Dose Imatinib Therapy.
Authors: J. Jovanovic, A. Reiter, D. Cilloni, E. Gottardi, J. Score, H. Popp, G. Metzgeroth, C. Walz, A. Hochhaus, C. Roche, C. Preudhomme, M. Rondoni, E. Ottaviani, F. Rancati, E. Solomon, J. Apperley, G. Martinelli, G. Saglio, R. Hehlmann, N. C.P. Cross, D. Grimwade
Journal: Blood (2005)
554. Evaluation of Viral Vector Gene Delivery Systems in Endothelial Cells In Vitro and Ex Vivo
Authors: Yanjuan Lin, Anming Xiong, Maria T. Millan
Journal: Molecular Therapy (2005)

Background: So far, we haven't found any previous report attempted to transduce latent membrane protein (LMP1) of Epstein-Barr virus (EBV) to endothelial cells of thoracic aorta segments of rat (EC-TASR).We have reported that LMP1 protects human endothelial cells apoptosis in vitro by upregulating anti-apoptotic genes. To determine whether EBV LMP1 protects endothelial cells (EC) against apoptosis in vivo, adenovirus and retrovirus delivery systems were used to deliver LMP1 into EC. We compared the transduction efficiency of recombinant virus in human umbilical vein endothelial cells (HUVEC), bovine aorta endothelial cells (BoAEC) and EC-TASR.
Stem Cells Created From Somatic Cells
Authors: Bridget M Kuehn
Journal: JAMA (2005)

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