The Natural History of the Autonomous Hyperfunctioning Thyroid Nodule
Authors: GERALD E. SILVERSTEIN
Journal: Annals of Internal Medicine (1967)

Article1 September 1967The Natural History of the Autonomous Hyperfunctioning Thyroid NoduleGERALD E. SILVERSTEIN, M.D., GERALD BURKE, M.D., C.M., R. COGAN, M.D.GERALD E. SILVERSTEIN, M.D.Search for more papers by this author, GERALD BURKE, M.D., C.M.Search for more papers by this author, R. COGAN, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-67-3-539 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe autonomous hyperfunctioning thyroid nodule is a well-established clinical entity (1, 2). Although the presence of such nodules has been associated in some instances with thyrotoxicosis, many patients with nodules sufficiently hyperactive to cause complete suppression of pituitary thyroid-stimulating hormone (TSH) production—and, in consequence, suppression of function within extranodular thyroid tissue—have been found to be clinically euthyroid (2-6). Whether any or all of these patients might ultimately become hyperthyroid has been the subject of considerable speculation (2, 7). A number of investigators (2, 5-10) have reported their cumulative experience with solitary hyperfunctioning thyroid nodules; however, since the vast majority of...References1. COPERAWSONMCARTHUR ORWJW: The hyperfunctioning single adenoma of the thyroid. Surg. Gynec. Obstet. 84: 415, 1947. MedlineGoogle Scholar2. SHELINEMCCORMACK GEK: Solitary hyperfunctioning thyroid nodules. J. Clin. Endocr. 20: 1401, 1960. CrossrefGoogle Scholar3. MILLERHAMBURGER JMJI: The thyroid scintigram. I. The hot nodule. Radiology 84: 66, 1965. CrossrefMedlineGoogle Scholar4. FELLINGERHOFEREGERTVETTER KRHH: Clinical and laboratory observations in patients with hyperactive thyroid nodules, in Advances in Thyroid Research, edited by PITT-RIVERS, R. Pergamon Press, Oxford, 1961, p. 347. Google Scholar5. SAVOIE JC: Étude clinique et biologique de quarante-trois cas d'adenome toxique thyroïden. Rev. Franc. Étud. Clin. Biol. 6: 263, 1961. MedlineGoogle Scholar6. MOLNARWILBERLEEWOOLNERKEATING GDRDRELBFR: On the hyperfunctioning solitary thyroid nodule. Mayo Clin. Proc. 40: 665, 1965. MedlineGoogle Scholar7. VAGUESIMONINMILLERALLAND JRGA: Diagnosis and evolution of autonomous secreting thyroid nodules, in Current Topics in Thyroid Research, edited by CASSANO, C., ANDREOLI, M. Academic Press, Inc., Publishers, New York, 1965, p. 883. Google Scholar8. GREENEFARRAN RHE: On single "hot" nodules of the thyroid gland. J. Endocr. 33: 537, 1965. CrossrefMedlineGoogle Scholar9. GILBERT-DREYFUSGALI P: Les criteres de guerison des adenomes toxiques traités par l'iode radio-actif. Rev. Franc. Endocr. Clin. 4: 27, 1963. Google Scholar10. LOBOROSENTHALFRIDMAN LCDJ: Evolution of autonomous thyroid nodules, in Current Topics in Thyroid Research, edited by CASSANO, C., ANDREOLI, M. Academic Press, Inc., Publishers, New York, 1965, p. 892. Google Scholar11. BARKERHUMPHREYSOLEY SBMJMH: The clinical determination of protein-bound iodine. J. Clin. Invest. 30: 55, 1951. CrossrefMedlineGoogle Scholar12. GROSSMANGROSSMAN AGF: Protein-bound iodine by alkaline incineration and a method for producing a stable cerate color. J. Clin. Endocr. 15: 354, 1955. CrossrefGoogle Scholar13. BURKE G: The triiodothyronine suppression test. Amer. J. Med. 42: 600, 1967. CrossrefMedlineGoogle Scholar14. DOBYNSLENNON BMB: A study of the histopathology and physiologic function of thyroid tumors, using radioactive iodine and radioautography. J. Clin. Endocr. 8: 732, 1948. CrossrefGoogle Scholar15. GOROWSKICHOMICKI TO: Diagnosis of nontoxic "warm" thyroid nodules independent of TSH. J. Clin. Endocr. 22: 1267, 1962. CrossrefGoogle Scholar16. DORTA T: L'utilité de la scintigraphie pour le diagnostic des maladies thyroïdiennes et quelques considerations sur le metabolisme de l'iode du goitre nodulaire. Schweiz. Med. Wschr. 90: 1344, 1960. MedlineGoogle Scholar17. SKILLERNMCCULLAGHCLAMEN PGEPM: Radioiodine in diagnosis and therapy of hyperthyroidism. Arch. Intern. Med. (Chicago) 110: 888, 1962. CrossrefMedlineGoogle Scholar18. MILLERHORNBLOCK JMRCMA: The evolution of toxic nodular goiter. Arch. Intern. Med. (Chicago) 113: 72, 1964. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Chicago, IllinoisFrom the Radioisotope Laboratory, Division of Metabolism and Endocrinology, Department of Medicine, Michael Reese Hospital and Medical Center, Chicago, Ill.Requests for reprints should be addressed to Gerald Burke, M.D., Director, Radioisotope Laboratory, Michael Reese Hospital, Chicago, Ill. 60616. 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Causes, etiology of Graves’ disease, clinical features, general aspects of treatmentPlummer's DiseaseSolitary autonomously functioning thyroid lesionsSERUM TRIIODOTHYRONINE IN SOLITARY AUTONOMOUS NODULES OF THE THYROIDSolitary Autonomous Thyroid NodulesThe Thyroid GlandThyroid 'hot' nodulesThyroid NoduleLaboratory Aids in the Diagnosis of Endocrine DisordersAUTONOMOUS THYROID NODULESN. DAVID CHARKES, M.D.AUTONOMOUS THYROID NODULESN. DAVID CHARKES, M.D. 1 September 1967Volume 67, Issue 3_Part_1Page: 539-548KeywordsEndocrinologyHistory of medicineHospital medicineResearch laboratoriesThyroidThyroid-stimulating hormone Issue Published: 1 September 1967 PDF DownloadLoading ...