Immunologic "Short Circuits"
Authors: GÖRAN KRONVALL
Journal: Annals of Internal Medicine (1969)

Editorial Notes1 May 1969Immunologic "Short Circuits"GÖRAN KRONVALL, M.D., RALPH C. WILLIAMS JR., M.D.GÖRAN KRONVALL, M.D.Search for more papers by this author, RALPH C. WILLIAMS JR., M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-70-5-1043 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptSome recent findings documenting exciting although rather anomalous short circuits in current biological thought have prompted us to reemphasize the obvious fact that many diverse biological processes are interrelated—sometimes in unexpected and exciting ways. We have chosen four examples to indicate the well-known experience that when two seemingly incoordinated or widely disparate fields of investigation cross, important biological phenomena may be perceived.The first example of an interesting biological short circuit is the recent demonstration by Gewurz and co-workers (1, 2) that purified lipopolysaccharide can react directly with components of complement, apparently without benefit of discernible antibody. This group's idea...References1. GEWURZMERGENHAGENNOWOTNYPHILLIPS HSEAJK: Interactions of the complement system with native and chemically modified endotoxins. J. Bact. 95: 397, 1968. CrossrefMedlineGoogle Scholar2. GEWURZSHINMERGENHAGEN HHSSE: Interactions of the complement system with endotoxic lipopolysaccharide: consumption of each of the six terminal complement components. J. Exp. Med. 128: 2049, 1968. CrossrefGoogle Scholar3. WESTPHALLÜDERITZ OO: Chemische enforschung von lipopolysacchariden gram negativer bakterien. Angew. 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Med. 127: 411, 1968. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Department of Medicine University of Minnesota Hospitals Minneapolis, Minn. 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