tbuckley/cabot-search huggingface dataset:
FDG-PET Adapted Sequential Therapy With Brentuximab Vedotin and Augmented ICE Followed By Autologous Stem Cell Transplant For Relapsed and Refractory Hodgkin Lymphoma
Authors: Alison Moskowitz, Heiko Schoder, John F. Gerecitano, Paul Hamlin, Steven M. Horwitz, Matthew J Matasar, Vahakn S Keskinyan, Susan McCall, Ariela Noy, M. Lia Palomba, Carol S. Portlock, David J Straus, Joachim Yahalom, Anas Younes, Andrew D Zelenetz, Craig H. Moskowitz
Journal: Blood (2013)
Cromolyn blocks S100P activation of RAGE, reduces pancreatic cancer growth and invasion and enhances gemcitabine chemotherapy
Authors: Thiruvengadam Arumugam, Vijaya Ramachandran, Craig D. Logsdon
Journal: Cancer Research (2006)

Proc Amer Assoc Cancer Res, Volume 47, 2006

4625 

Background: Pancreatic cancer remains an oncological challenge with a 5-year survival rate below 5%. Current therapies are unsatisfactory and patient outcome is dismal such that new treatments are desperately needed. Previously, we found that S100P is over expressed in more than 90% of pancreatic cancer, is secreted by cancer cells, activates the receptor for advanced glycation end-products (RAGE) and plays a major role in tumor growth and invasion (Clinical. Can. Res.2005 Aug 1;11(15):5356-64). Recent publications suggested that the anti-allergic drug cromolyn might interact with S100 molecules. Therefore, in the current study we sought to examine the ability of cromolyn to bind with S100P and inhibit its interactions with RAGE and its effects on pancreatic cancer. Methods: A cromolyn drug affinity column was used to determine the interaction between S100P and cromolyn. The ability of cromolyn to interfere with the interaction of S100P with its receptor RAGE was analyzed by co-immunoprecipitation studies. Cancer cell growth and invasion were analyzed with cells without endogenous S100P (Panc-1) and also cells with endogenous S100P (BxPc3 and Mpanc-96) in vitro and in vivo . In orthotopic tumor models, cromolyn (5mg/k.g.b.wt/daily by i.p.) was administered with and without gemcitabine (125mg/k.g.bt/twice a month) and tumor growth and invasion were monitored using bioluminescence imaging every week for six weeks. Results: S100P was retained by a cromolyn drug affinity column, indicating a direct interaction between these molecules. Cromolyn also blocked the interaction of S100P and RAGE in co-immunoprecipitation experiments. In vitro , cromolyn inhibited the growth and invasiveness of pancreatic cancer cells with endogenous S100P (BxPc3 and Mpanc-96), but not Panc-1 cells that lack endogenous S100P. In orthotopic tumor models, cromolyn treatment significantly reduced the growth and metastasis of tumors developed from S100P expressing cancer cells (BxPc3 and Mpanc-96) but not cancer cells lacking S100P (Panc-1). Cromolyn also enhanced the efficiency of gemcitabine and effects of the combination were greater than either drug alone. The combination resulted in a dramatic reduction in tumor growth (BxPc3 and Mpanc-96) and the almost complete absence of metastasis to liver and lung. Conclusion: Our findings suggest that cromolyn, through its ability to interfere with S100P activation of RAGE, inhibits pancreatic cancer growth and metastasis and increases the efficiency of chemotherapy. Thus, cromolyn treatments should be considered to enhance standard chemotherapy for pancreatic cancer.
Depression and Parkinson's disease: a review
Authors: J L Cummings
Journal: American Journal of Psychiatry (1992)

The purpose of this review is to provide an update of the research regarding depression in Parkinson's disease and to synthesize the information into a neurobiological model relating the structural and biochemical changes in this disorder to the behavioral manifestations.The author used a computer-based search of the literature, augmented by extensive bibliography-guided article reviews, to find information on depression and Parkinson's disease.Depression occurs in approximately 40% of patients with Parkinson's disease; depression in Parkinson's disease is distinguished from other depressive disorders by greater anxiety and less self-punitive ideation. Lower CSF levels of 5-hydroxyindoleacetic acid, a past history of depression, and greater functional disability are associated with a greater risk of depression in Parkinson's disease. Female gender, early age at onset of Parkinson's disease, and greater left brain involvement may also be risk factors. Approximately half of depressed patients with Parkinson's disease meet criteria for major depressive episodes; half have dysthymia. Depression is more common in Parkinson's disease with prominent bradykinesia and gait instability than in tremor-dominant syndromes. Depressed patients with Parkinson's disease have greater frontal lobe dysfunction and greater involvement of dopaminergic and noradrenergic systems than nondepressed patients with the disease. Mood changes in Parkinson's disease respond to treatment with conventional tricyclic antidepressants or ECT.Neurobiological investigations suggest that depression in Parkinson's disease may be mediated by dysfunction in mesocortical/prefrontal reward, motivational, and stress-response systems. Neuropsychological, metabolic, clinical, pharmacological, and anatomical studies support the involvement of frontal dopaminergic projections in patients with Parkinson's disease and depression.
Nilotinib combined with multiagent chemotherapy for newly diagnosed Philadelphia-positive acute lymphoblastic leukemia
Authors: Dae-Young Kim, Young-Don Joo, Sung-Nam Lim, Sung-Doo Kim, Jung-Hee Lee, Je-Hwan Lee, Dong Hwan (Dennis) Kim, Kihyun Kim, Chul Won Jung, Inho Kim, Sung-Soo Yoon, Seonyang Park, Jae-Sook Ahn, Deok-Hwan Yang, Je-Jung Lee, Ho-Sup Lee, Yang Soo Kim, Yeung-Chul Mun, Hawk Kim, Jae Hoo Park, Joon Ho Moon, Sang Kyun Sohn, Sang Min Lee, Won Sik Lee, Kyoung Ha Kim, Jong-Ho Won, Myung Soo Hyun, Jinny Park, Jae Hoon Lee, Ho-Jin Shin, Joo-Seop Chung, Hyewon Lee, Hyeon-Seok Eom, Gyeong Won Lee, Young-Uk Cho, Seongsoo Jang, Chan-Jeoung Park, Hyun-Sook Chi, Kyoo-Hyung Lee
Journal: Blood (2015)
Abstract 13048: Impact of Atrial Fibrillation on the Clinical Course of Apical Hypertrophic Cardiomyopathy
Authors: Sang Eun Lee, Jin-kyu Park, Jae-Sun Uhm, Jong-Youn Kim, Hui-Nam Pak, Moon-Hyoung Lee, Boyoung Joung
Journal: Circulation (2014)

Introduction: Apical hypertrophic cardiomyopathy (A-HCM) has been considered a “benign” form of HCM, with limited data on long-term outcome. However, the clinical impact of atrial fibrillation (AF) in A-HCM is largely unresolved. Hypothesis: We analyzed whether AF has a prognostic implication of in an A-HCM cohort. Methods: Occurrence of AF and outcome were assessed in 346 consecutive A-HCM patients (age at diagnosis, 62 ± 11 years; 67.6% male) who were followed up for 6.3 ± 3.4 years. We compared mortality and stroke between A-CMP patients with and without AF. Results: AF occurred in 103 A-HCM patients (30%; incidence, 3%/y) and was independently predicted by advanced age and increased left atrial size (anteroposterior diameter < 45 mm) at diagnosis. Patients with AF had higher incidence of all cause death (11.7% vs. 2.1%, p < 0.001), cardiovascular death (7.8% vs. 0.8%, p = 0.001) and stroke (20.4% vs. 2.5%, p < 0.001) than those without AF. When adjusted with age and gender, patients with AF still had ...
Abstract MP27: Effects of Healthy Lifestyle Behaviors on Lifetime Risk of Chronic Disease Mortality and Life Expectancy in Men and Women
Authors: Chong-Do Lee
Journal: Circulation (2014)

The impact of healthy lifestyle behaviors on lifetime risk of chronic disease mortality and life expectancy in U.S. population remains less explored. Purpose: We investigated the combined effects of lifestyle factors on lifetime risk of chronic disease mortality and life expectancy in US men and women at 40 years of age. Methods: Lifetime risks of chronic disease mortality to 80 years of age were estimated for men and women, with death free of chronic diseases as a competing event. We followed 7848 men and women, aged 40 to 80 years, who participated in the Third National Health and Nutrition Examination Survey. All participants completed baseline lifestyle behavior questionnaires. A healthy lifestyle profile was defined as physically active, never smoking, and a healthy diet defined by the American Heart Association Strategic Committee. They were further categorized as having 0, 1, 2, or 3 combined healthy lifestyle factors. Results: During an average of 13.2 years of follow-up (103,851 person years), there were a total of 1645 chronic disease deaths (915 CVD, 546 cancer, 281 respiratory disease, 98 diabetes mellitus). The lifetime risks of chronic disease mortality (at 40 years of age) were 38.1% (95% CI: 35.7 to 40.5) and 30.7% (95% CI: 28.5 to 33.0) in men and women, respectively. Men and women who were physically active, never smoked, and had a healthy diet had a substantially lower lifetime risk of chronic disease mortality. The lifetime risks of chronic disease mortality across 0, 1, 2, and 3 combined healthy lifestyle factors were 47.2%, 33.0%, 21.2%, and 16.2%, respectively. After adjustment for multiple risk factors, men and women with all 3 healthy lifestyle factors had a 36% (95% CI: 28% to 42%) lower risk of chronic disease mortality compared with men and women with zero healthy lifestyle factors. Persons with 0 compared with 3 healthy lifestyle factors had a shorter life expectancy by 10 years (95% CI: 7.8 to 12.1 years). Approximately 30% (95% CI: 14% to 43%) of chronic disease deaths might have been avoided if men and women had maintained all 3 healthy lifestyle factors. Conclusion: Maintaining a healthy lifestyle is associated with lower risk of chronic disease mortality in men and women. Nationwide primordial and primary prevention efforts are needed to support the attainment of healthy lifestyles for the lifetime.
The Clinical Significance of Jaundice
Authors: M. A. Blankenhorn
Journal: Annals of Internal Medicine (1927)

Article1 August 1927The Clinical Significance of JaundiceM. A. BLANKENHORNM. A. BLANKENHORNSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-1-2-74 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTheories in the matter of jaundice and ideas, coming from the laboratory or the bedside, that contemplate the physiology and the pathology of bile pigment as anything other than an affair of the liver have never gone far in useful application. Stoppage of the gall ducts or gross abnormalities of the liver are so commonly the cause of jaundice that the liver and its ducts have always been the principal consideration when jaundice is to be explained.Virchow's (1) demonstration that a strange pigment which forms about extravasations of blood was identical with the bile pigment gave rise to a... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Lakeside Hospital Cleveland, Ohio*Presented at the Cleveland Clinical Week of the American College of Physicians, February 23, 1927. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 August 1927Volume 1, Issue 2Page: 74-79KeywordsBileBloodLiverResearch laboratories ePublished: 1 December 2008 Issue Published: 1 August 1927 PDF downloadLoading ...
Lesson of the week: Hyponatraemic seizures and excessive intake of hypotonic fluids in young children
Authors: P Bhalla, F E Eaton, J B S Coulter, F L Amegavie, J A Sills, L J Abernethy
Journal: BMJ (1999)

<h3>Abstract</h3> As COVID-19 cases resurge in the United States, understanding the complex interplay between human behavior, disease transmission, and non-pharmaceutical interventions during the pandemic could provide valuable insights to focus future public health efforts. Cell-phone mobility data offers a modern measurement instrument to investigate human mobility and behavior at an unprecedented scale. We investigate mobility data collected, aggregated, and anonymized by SafeGraph Inc. which measures how populations at the census-block-group geographic scale stayed at home in California, Georgia, Texas, and Washington since the beginning of the pandemic. Using nonlinear dimensionality reduction techniques, we find patterns of mobility behavior that align with stay-at-home orders, correlate with socioeconomic factors, cluster geographically, and reveal subpopulations that likely migrated out of urban areas. The analysis and approach provides policy makers a framework for interpreting mobility data and behavior to inform actions aimed at curbing the spread of COVID-19.
Abstract 16860: Epicardial Adipose Tissue Volume Predicts Extent of Left Atrial Fibrosis in Patients with Atrial Fibrillation
Authors: Mark G Rabbat, Bassel Sayegh, Andrew Stiff, Mushabbar A Syed, Brian Vetter, Kim Chan, Tonye Teme, David J Wilber
Journal: Circulation (2014)

Introduction:  Epicardial adipose tissue (EAT), located between the myo-epicardium and the visceral pericardium, has been associated with the incidence and severity of atrial fibrillation (AF) independent of known risk factors and body mass index (BMI). The secretome of EAT is metabolically active, releasing various adipokines and inflammatory mediators which may promote fibrosis in adjacent left atrial (LA) myocardium. New innovations in cardiac magnetic resonance imaging (CMR) allow LA fibrosis and EAT to be precisely quantified.   Hypothesis:  We assessed the hypothesis that increased EAT volume is associated with more extensive LA fibrosis.   Methods:  We studied 54 patients with AF who underwent CMR prior to ablation. Images were acquired on a 3T scanner (Siemens Trio) by SSFP using a standard short axis stack through the atria and ventricles. EAT was assessed volumetrically in consecutive short-axis views through the heart using the multi-slice method during end-diastole. Late gadolinium enhanced CMR was performed using customized pulse sequences and protocols for LA imaging (Marrek Inc, Salt Lake UT). An LA fibrosis score was quantified as the volumetric percentage of LA wall enhancement using custom software (Corview, Marrek).   Results:  Mean EAT volume was 120±62 cc, and LA fibrosis score was 14±7%. Mean age was 62±10 years, and 59% of patients were men. AF was paroxysmal in 76%. Comorbidities included hypertension in 52%, diabetes in 11%, and obstructive sleep apnea in 7%. Mean BMI and LA volumes were 28±5 kg/m 2  and 107±37ml, respectively. By univariate analysis, the LA fibrosis score was significantly correlated with EAT volume (r = 0.45, p=0.006), but not LA volume (r=0.14, p=0.42) or BMI (r=0.30, p=0.07). EAT volume remained the only significant predictor of fibrosis score in a multivariate linear regression model incorporating all other variables (p = 0.024).   Conclusions:  Increasing EAT volume is associated with a greater extent of LA fibrosis quantified by CMR in AF patients, independent of LA volume, BMI, and other AF risk factors. These data suggest that the EAT secretome may contribute to the fibrotic substrate of AF, and provide a novel target for therapeutic interventions.
非胰岛素依赖型糖尿病冠状动脉疾病的危险因素:英国糖尿病前瞻性研究(UKPDS:23)
Authors: Turner, Millns, Neil, Stratton, Manley, Matthews, Holman, 赵维纲
Journal: BMJ (1998)

为1.52（1.15～2.01）,收缩压为1.82（1.34～2.47）。吸烟者的估计风险比为1.41（1.06～1.88）。结论:2型糖尿病患者中,存在冠状动脉疾病潜在的、可变的5种危险因素的交叉重叠影响。它们是低密度脂蛋白胆固醇浓度升高、高密度脂蛋白胆固醇浓度降低、高血压、高血糖和吸烟。
Incidence of Dementia and Alzheimer Disease in Nigeria and the United States—Reply
Authors: Hugh C. Hendrie
Journal: JAMA (2001)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The Elements of Experimental Embryology
Authors: Julian Sorell Huxley, Gavin Rylands De Beer
Journal: JAMA (1934)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Abstract 13430: ‘Dyads’ Function as Ion Channel Hubs in Cardiac Myocytes and Junctophilin-2 Plays a Critical Role in Stabilizing Channel Expression in Dyads
Authors: Min Jiang, Yuhong Wang, Jose M Eltit, Mei Zhang, Alex Tan, Karoly Kaszala, Jose F Huizar, Ravi Balijepalli, Gea-Ny Tseng
Journal: Circulation (2014)

Background:  In cardiomyocytes t-tubules and junctional sarcoplasmic reticulum (jSR) come close to form ‘dyads’, where Ca influx through L-type Ca channels effectively activates Ca release through RyR2. Many other channels also cluster to t-tubules. How are they stabilized here is not clear. Junctophilin-2 (JPH-2) provides a scaffold stabilizing dyads in cardiomyocytes. Whether JPH-2 is also involved in stabilizing channels in t-tubules is not clear. We reported that in a canine model of premature ventricular contraction (PVC)-induced cardiomyopathy JPH-2 protein was conspicuously reduced. This allows us to study how changes in JPH-2 may impact on protein level and distribution of ion channels in dyads.   Methods:  Immunoblotting, immunofluorescence/confocal microscopy, [Ca] i  monitoring and patch clamp.   Results:  (1) JPH-2 reduction is associated with decrease in Cav1.2, RyR2, KCNQ1, and ERG1, but increase in KCNE1. There is no correlation between JPH-2 and KCNE2, Kv4.3, KChIP2, Kir2.1 or Kir2.2. Thus, decrease in JPH-2 selectively impacts on L-type Ca, RyR2, I Ks  and I Kr  channels, but not I to  or I K1  channels. (2) There is no correlation between ion channels and other dyad scaffolding proteins: BIN1, caveolin-3, ankyrin-B, and telethonin. (3) PVC myocytes have more and larger LAMP1 +  (lysosomal marker) vesicles than CON myocytes, and most LAMP1 +  vesicles are also positive for JPH-2, suggesting that PVC-associated stress activates autophagy which enhances JPH-2 degradation. (4) Loss of JPH-2 impairs E-C coupling, due to downregulation of RyR2 and Cav1.2, and a misalignment between the two. (5) Loss of JPH-2 reduces t-tubule density, causing a redistribution of KCNQ1 from dyads to lateral surface membrane. (6) Loss of JPH-2 paradoxically increases I Ks , that helps action potential repolarization when I K1  and I to  are both down-regulated, i.e. I Ks  as a ‘repolarization reserve’.   Conclusion:  JPH-2 is critical in stabilizing ion channels in dyads. Stress-induced autophagy targets JPH-2, leading to dyad remodeling, downregulation and/or redistribution of key ion channel subunits. The functional consequences can be detrimental (E-C coupling impairment) but also protective (increase in I Ks  to protect against excessive action potential prolongation).
Abstract 4078: EZH2 marks polyfunctional memory T cells and controls tumor immunity
Authors: Ende Zhao, Tomasz Maj, Ilona Kryczek, Lili Zhao, Shuang Wei, Shanshan Wan, Joel Crespo, Wojciech Szeliga, Linda Vatan, Ke Wu, Arul M. Chinnaiyan, Theodore H. Welling, Victor E. Marquez, Jan Kotarski, Yi Zhang, Rebecca Liu, Kaixiong Tao, Guobin Wang, Weiping Zou
Journal: Cancer Research (2014)

Abstract Polyfunctional T cells mediate potent anti-viral immunity. However, the nature and molecular mechanisms controlling their functional signature remain poorly understood. Here we report that polyfunctional T cells are characterized by high proliferative capacity and apoptotic resistance. Enhancer of zeste homolog 2 (EZH2) phenotypically marks them and functionally controls their survival and expansion. Notch signaling regulates effector T cell function. We show that EZH2 represses Numb and Fbxw7, two Notch repressors, activates Notch signaling, and Notch subsequently stimulates Bcl-2 expression and protects EZH2+ T cells from apoptosis via trimethylating histone H3 on lysine 27. Moreover, EZH2 targets T cell cycling repressors and promotes their expansion. EZH2+CD8+ T cells mediate anti-tumor immunity and are associated with improved long-term cancer survival. Together, the data reveal a novel role and mechanism for EZH2 in controlling polyfunctional T cells. Thus, manipulation of EZH2 signaling in T cells may have therapeutic potential in treating cancer patients. Citation Format: Ende Zhao, Tomasz Maj, Ilona Kryczek, Lili Zhao, Shuang Wei, Shanshan Wan, Joel Crespo, Wojciech Szeliga, Linda Vatan, Ke Wu, Arul M. Chinnaiyan, Theodore H. Welling, Victor E. Marquez, Jan Kotarski, Yi Zhang, Rebecca Liu, Kaixiong Tao, Guobin Wang, Weiping Zou. EZH2 marks polyfunctional memory T cells and controls tumor immunity. [abstract]. In: Proceedings of the 105th Annual Meeting of the American Association for Cancer Research; 2014 Apr 5-9; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2014;74(19 Suppl):Abstract nr 4078. doi:10.1158/1538-7445.AM2014-4078