Clinical and Experimental Observations on the Treatment of Pernicious Anemia with Desiccated Stomach and with Liver Extract
Authors: Cyrus C. Sturgis, Raphael Isaacs
Journal: Annals of Internal Medicine (1931)

Article1 August 1931Clinical and Experimental Observations on the Treatment of Pernicious Anemia with Desiccated Stomach and with Liver ExtractCYRUS C. STURGIS, M.D., F.A.C.P., RAPHAEL ISAACS, M.D., F.A.C.P.CYRUS C. STURGIS, M.D., F.A.C.P.Search for more papers by this author, RAPHAEL ISAACS, M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-5-2-131 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptINTRODUCTIONThe possibility that a defect in the stomach may be related to the etiology of pernicious anemia has been recognized for many years. This belief has been based upon a number of clinical facts, some of which have been established and confirmed by numerous observers. The most significant evidence suggesting this etiological relationship is that every patient, probably without exception, has at least a functional impairment of the stomach mucosa as indicated by the inability to secrete hydrochloric acid. This fact becomes even more significant now that it is known that hydrochloric acid is not secreted under the powerful...Bibliography1 CASTLELOCKE WBEA: Observations on the etiologic relationship of achylia gastrica to pernicious anemia. Jr. Clin. Invest. 1928. vi, 3-4. Google Scholar CASTLETOWNSENDHEATH WBWCCW; Etiological relationship of achylia gastrica to pernicious anemia. Lancet, 1930, i, 1062-3. CrossrefGoogle Scholar CASTLE WB: Observations on the etiologic relationship of achylia gastrica to pernicious anemia. I. The effect of the administration to patients with pernicious anemia of the contents of the normal human stomach recovered after the ingestion of beef muscle, Am. Jr. Med. Sci., 1929, clxxviii, 748-764. CrossrefGoogle Scholar CASTLETOWNSEND WBWC: Observations on the etiologic relationship of achylia gastrica to pernicious anemia. II. The effect of the administration to patients with pernicious anemia of beef muscle after incubation with normal human gastric juice, Am. Jr. Med. Sci., 1929, clxxviii, 764-777. CrossrefGoogle Scholar2 STURGISISAACS CCR: Desiccated stomach in the treatment of pernicious anemia, Jr. Am. Med. Assoc., 1929, xciii, 747-749. CrossrefGoogle Scholar3 ISAACSSTURGIS RCC: Some newer remedies in the treatment of pernicious anemia; desiccated stomach, Jr. Am. Med. Assoc., 1930, xcv, 585-587. CrossrefGoogle Scholar4 MINOTCOHNMURPHYLAWSON GREJWPHA: Treatment of pernicious anemia with liver extract; Effects upon the production of immature and mature red blood cells, Am. Jr. Med. Sci., 1928, clxxv, 599. CrossrefGoogle Scholar5 RIDDLE MC: Blood regeneration in pernicious anemia during early remission, Arch. Int. Med., 1930, xlvi, 417-439. CrossrefGoogle Scholar6 MEULENGRACHTHECHT-JOHANSEN EA: Behandlung der Perniziösen Anämie mit Magen und Magenextrakt, Klin. Wchnschr., 1930, ix, 1162-1165. Ugesk. f. Laeger, 1930, xcii, 405-409. CrossrefGoogle Scholar7 COHNMINOTALLESSALTER EJGRGAWT: The nature of the material in liver effective in pernicious anemia, II. Jr. Biol. Chem., 1928, lxxvii, 325-358. CrossrefGoogle Scholar8 SHARP EA: An antianemic factor in desiccated stomach, Jr. Am. Med. Assoc., 1929, xciii, 749. CrossrefGoogle Scholar9 MINOTMURPHY GRWP: A diet rich in liver in the treatment of pernicious anemia, Jr. Am. Med. Assoc., 1927, lxxxix, 759-768. CrossrefGoogle Scholar10 RIDDLESTURGIS MCCC: The effect of single massive doses of liver extract on patients with pernicious anemia, Am. Jr. Med. Sci., 1930, clxxx, 1-11. CrossrefGoogle Scholar11 RENSHAW A: Treatment of pernicious anemia with desiccated hog's stomach, Brit. Med. Jr., 1930, i, 334-335. CrossrefGoogle Scholar12 SNAPPERDUPREEZ IJD: Behandeling von pernicieuse anaemie met Poeder von Gedroogde Varkensmagen, Nederlandsch Tijdschrift voor Geneeskunde, 1930, lxxiv, 745-747. Nederlandsch Tijdschrift voor Geneeskunde, 1931, lxxv, 29-48. Google Scholar13 CASTELLANI A: Brief notes on the administration of liver, pancreas and stomach extracts in sprue, Jr. Trop. Med. and Hyg., 1930, xxxiii, 126. Google Scholar14 CONNER HM: The treatment of pernicious anemia with raw and cooked swine stomach, Jr. Am. Med. Assoc., 1930, xciv, 388-390. Jr. Am. Med. Assoc., 1931, xcvi, 500. CrossrefGoogle Scholar15 WILKINSON JF: Pernicious anemia; preliminary report on the results obtained by treatment with certain preparations of stomach, Brit. Med. Jr., 1930, i, 236-239. CrossrefGoogle Scholar16 ROSENOW G: Behandlung der perniziösen Anämie mit getrocknetem Schweinemagen, Klin. Wchnschr., Berl., 1930, ix, 652-653. CrossrefGoogle Scholar17 HITZENBERGER : Case report, Proc. Gesellsch. f. inn. Med. in Wien., Wien. klin. Wchnschr., 1930, ix, 293. Google Scholar18 NITTIS S: Blood platelets in pernicious anemia after liver therapy, Ann. Int. Med., 1931, iv, 931-938. Google Scholar19 GOLDHAMER SM: Non-development of eosinophilia in pernicious anemia patients treated with desiccated stomach, Ann. Int. Med., 1931, iv, 1105-1107. Google Scholar20 PORTERIRVING WBH: Reticulocytosis produced by liver extract, Arch. Int. Med., 1929, xliv, 502-503. CrossrefGoogle Scholar21 KANDEL E: Ventriculin in the treatment of pernicious anemia patients on meat free diet, Proc. Soc. Exp. Biol. and Med., 1931, xxviii, 385-389. CrossrefGoogle Scholar22 GEUTING H: Treatment of pernicious anemia with stomopson, Deutsch. med. Wchnschr., 1930, lvi, 1219-1220. Google Scholar23 LESCHKE E: Die magentherapie leberrefraktarer Falle von perniziösen Anämie, Med. Klin., Berl., 1930, xxvi, 1445-1446. Google Scholar24 DECASTELLO A: Erfahrungen über die Behandlung der perniziösen Anämie mit dem Magenpräparat Venträmon, Med. Klin., Berl., 1930, xxvi, 1444-1445. Google Scholar25 BERTRAM F: Klinisches zur Behandlung der Anämien mit Magenpräparaten, Klin. Wchnsch., Berl., 1930, ix, 2103. CrossrefGoogle Scholar26 HENNINGSTIEGER NG: Die Behandlung der perniziösen Anämie mit Magenschleimhautpräparaten, Klin. Wchnschr., 1930, ix, 2145. CrossrefGoogle Scholar27 BAUERWOZASEK RO: Influence of ergotamine and of liver diet on functioning of liver, Wien. klin. Wchnschr., 1930, xliii, 1337. Google Scholar28 FABER K: Die Behandlung der perniziösen Anämie mit getrockneter Magensubstanz, Ugeskrift f. Laeger, Copenhagen, 1930, xcii, 467-468. Google Scholar29 WINGE K: Pernicious anemia; treatment with desiccated stomach, Ugeskrift f. Laeger, Copenhagen, 1930, xcii, 511. Google Scholar30 TORRNING K: Pernicious anemia treated with dried stomach; case, Ugesk. f. Laeger, Copenhagen, 1930, xcii, 510. Google Scholar31 HOLBOLL SA: Treatment of pernicious anemia with dried stomach, Hospitalstidende, Copenhagen, 1930, lxxii, 825. Google Scholar32 UNGLEY CC: The stomach and pernicious anemia, Newcastle Medical Journal, 1929, x, 14-39. Google Scholar33 LENHARTZ H: Ersetzt Organsubstanz aus Schweinemagen die Leber bei Behandlung der Biermerchen Krankheit? Deutsch. med. Wchnschr. 1930, lvi, 1872-1873. Google Scholar34 DOMINQUEZBIZZOZERO CRC: Sindrome neuro-anemico; Tratamiento por la ingestion de e stomago de cerdo desecado, El. Dia Medico, 1930, iii, 49. Google Scholar35 GUTZEIT K: Über die Behandlung des Morbus Biermer mit Magenpulver (Ventraemon), Münch. med. Wchnschr., 1930, lxxvii, 1625-1626. Google Scholar36 ALLERTON GT: Desiccated hog stomach in pernicious anemia, Lancet, 1930, ii, 795. CrossrefGoogle Scholar37 GODEL R: Behandlung der perniziösen Anämie mit Ventraemon (Magenpräparat), Wien. klin. Wchnschr., 1930, xliii, 812-814. Google Scholar38 HERZ A: Therapie der Anämien, Wien. klin. Wchnschr., 1930, xliii, 1189-1194. Google Scholar39 BURGESSMORGAN JPJE: Effect of various stomach preparations in pernicious anemia, Proc. Soc. Exp. Biol. and Med., 1931, xxviii, 371-372. CrossrefGoogle Scholar40 LAMBINSTEENHOUDT PJ: Essai de traitement de l'anemie pernicieuse par des preparations d'estomac desseche, Bull. et Mem. de la Soc. Méd. des Hôp. de Par., 1930, xlvi, 986-991. Google Scholar41 JAGICKLIMA NR: Zur Therapie der perniziösen Anämie mit Ventraemon, Wien. klin. Wchnschr., 1930, xliii, 877-878. Google Scholar42 MOUZON J: Stomach therapy in pernicious anemia, Presse méd., 1930, xxxviii, 847-850. Google Scholar43 Unpublished observations of the authors. Google Scholar44 Personal communication from Dr. R. M. McKean and Dr. E. A. Sharp. Paper in press. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Ann Arbor, Michigan*From the Thomas Henry Simpson Memorial Institute for Medical Research, University of Michigan, Ann Arbor, Michigan.†Read at the Baltimore Meeting of the American College of Physicians, March 27, 1931. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byDie Erkrankungen des erythrocytären SystemsThe relation of gastrectomy to anemiaPhysiologie und Pathologie des Antiperniciosaprinzips 1 August 1931Volume 5, Issue 2Page: 131-158KeywordsEtiologyHydrochloric acidLiverMucous membranesPernicious anemiaStomach ePublished: 1 December 2008 Issue Published: 1 August 1931 PDF downloadLoading ...