tbuckley/cabot-search huggingface dataset:
Abstract PR07: Transcriptome meta-analysis identifies new 5-gene classifier for early detection of pancreatic cancer
Authors: Manoj Bhasin, Octavian Bucur, Ken Ndebele, Jessica Plati, Andrea Bullock, Xuesong Gu, Eduardo Castan, Robert Najarian, Jen Jen Yeh, Channing Der, Jon Cody Haines, Karl Ruping, Rebecca Miksad, Roya Khosravi-Far, Towia Aron Libermann
Journal: Cancer Research (2015)

Abstract Background: Pancreatic ductal adenocarcinoma (PDAC) is a truly devastating disease, primarily due to late diagnosis when curative resection is no longer possible and the lack of accurate early detection biomarkers. Therefore, increasing PDAC survival depends heavily on improving the accuracy and effectiveness of early PDAC detection. Methods:Key PDAC biomarkers were identified through an optimized meta-analysis strategy of raw data in 4 PDAC transcriptome datasets (training sets). Application of identical normalization and statistical testing procedures for each dataset generated a list of differentially expressed genes by empirical Bayes moderated t-statistic. The top ranking PDAC-specific genes from this list that were consistently differentially expressed in these training sets were used for developing a classifier for PDAC. The biomarker panel with the highest sensitivity and specificity in the training sets was validated for diagnostic performance in nine independent validation datasets. A subset of genes in the panel were evaluated by immunohistochemistry (IHC) in human PDAC tissue sections. Cell based assays assessed the effect of two genes on PDAC migration and invasion. Results and Conclusions: A 5-gene classifier panel was identified that disntinguished between PDAC and normal pancreas with high sensitivity, specificity and accuracy in the four training sets. Validation of this 5-gene predictor in 9 independent test sets confirmed the diagnostic accuracy to not only discriminate accurately between PDAC and healthy controls, but also between pancreatitis and PDAC. IHC analysis of two of the proteins encoded by the panel confirmed enhanced expression in PDAC cells. Cell-based experiments demonstrated that both proteins enhance migration and invasion of PDAC cells as well as soft agar growth, suggesting a causal link to PDAC development and progression. The immediate clinical utility upon further prospective validation of this PDAC biomarker panel will be accurate PDAC diagnosis in patients with pancreatic abnormalities on imaging, risk stratification and evaluation of the risk of malignancy in pancreatic cysts. This abstract is also presented as Poster B26. Citation Format: Manoj Bhasin, Octavian Bucur, Ken Ndebele, Jessica Plati, Andrea Bullock, Xuesong Gu, Eduardo Castan, Robert Najarian, Jen Jen Yeh, Channing Der, Jon Cody Haines, Karl Ruping, Rebecca Miksad, Roya Khosravi-Far, Towia Aron Libermann. Transcriptome meta-analysis identifies new 5-gene classifier for early detection of pancreatic cancer. [abstract]. In: Proceedings of the AACR Special Conference on Pancreatic Cancer: Innovations in Research and Treatment; May 18-21, 2014; New Orleans, LA. Philadelphia (PA): AACR; Cancer Res 2015;75(13 Suppl):Abstract nr PR07.
Gemcitabine plus cisplatin in patients with locally advanced or metastatic breast cancer (MBC) who failed prior anthracycline therapy +/− taxanes
Authors: A. El Khodary, Y. Gouda, S. Al Noweim, H. Kohail, R. Gaafar, H. Zawahry, A. A. Wareth, O. Mansour, S. Shehata, T. A. Hamid
Journal: Journal of Clinical Oncology (2004)

769 Background: Many relapsed MBC patients (pts) who were pretreated with taxanes and anthracyclines require an effective and tolerable treatment. The primary objective of the study was to evaluate the overall response rate (ORR) of gemcitabine and cisplatin in pretreated pts with locally advanced or MBC. Secondary objectives were response duration, time to progressive disease (TTPD), toxicity, and 1-year and overall survival. This abstract presents the results of the interim analysis. Methods: Pts with unresectable locally recurrent or MBC who were pretreated with one anthracycline-containing chemotherapy +/- taxanes in a neo/adjuvant or first-line metastatic setting received up to 6 cycles of gemcitabine 1250 mg/m2 (d1, 8) plus cisplatin 70 mg/m2 (d1) every 21 days. Other criteria included: age 18–75 yrs; KPS >70; prior hormonal therapy; adequate bone marrow, liver, and kidney functions; life expectancy >6 mos; and written informed consent. Results: From July 2002 to April 2003, 50 pts with a median age of 47.5 yrs (range, 28–64 yrs) received 219 cycles of treatment, with a mean of 4.38 cycles (range, 1–6 cycles). Baseline characteristics included: 3 (6%) and 47 (94%) pts, respectively, with locally advanced and metastatic disease; 15 (30%) premenopausal and 35 (70%) postmenopausal pts; and 19 (38%) ER+, 14 (28%) ER-, and 17 (34%) unknown ER pts. All pts received prior anthracyclines: 37 (74%) in adjuvant setting and 13 (26%) in locally advanced or metastatic setting; 11 (22%) pts received taxanes for advanced disease. Tamoxifen was received by 24 (48%) pts in adjuvant setting and 7 (14%) pts for advanced disease. All pts were evaluable for response and toxicity. Complete and partial response occurred in 7 (14%) and 15 (30%) pts, respectively, for an ORR of 44%; 16 (32%) pts had progressive disease. The main hematologic and nonhematologic toxicities were grade 3/4 anemia in 26%/12%, neutropenia in 10%/10%, and nausea/vomiting in 32% of pts. Conclusions: Gemcitabine plus cisplatin is active and safe in pts with locally advanced or MBC previously treated with anthracyclines +/- taxanes. Recruitment is ongoing. No significant financial relationships to disclose.
HEART DISEASE IN THE JUNGLES OF THE SOUTH PACIFIC: SOME OBSERVATIONS MADE AMONG THE MELANESIANS OF THE NEW HEBRIDES AND SOLOMONS ISLANDS AREA
Authors: Albert Salisbury Hyman
Journal: Annals of Internal Medicine (1945)

Article1 May 1945HEART DISEASE IN THE JUNGLES OF THE SOUTH PACIFIC: SOME OBSERVATIONS MADE AMONG THE MELANESIANS OF THE NEW HEBRIDES AND SOLOMONS ISLANDS AREAALBERT SALISBURY HYMAN, F.A.C.P.ALBERT SALISBURY HYMAN, F.A.C.P.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-22-5-639 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptPREFACEIn the spring of 1942 a new page was written into the history of United States naval warfare; the technic of "island hopping" was being developed in the South Pacific theatre of the war. As island after island of the New Hebrides and Solomons groups was wrested from enemy control, the plan of occupation called for perfect timing and teamwork between marine combat fighting units, naval construction battalions, and the task force land based staff which included the medical, communications, and supply stations. From out of wild jungle terrain there were hacked almost over night temporary landing strips and...Bibliography1. HYMAN AS: Clinical masquerades of malaria, U. S. Naval Med. Bull. To be published. Google Scholar2. HYMAN AS: Cardiovascular disease in the tropics, U. S. Naval Med. Bull., 1944, xlii, 545. Google Scholar3. HYMAN AS: The heart in dengue, War Med., 1943, iv, 497. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: *Received for publication January 6, 1945.This article has been released for publication by the Division of Publications of the Bureau of Medicine and Surgery of the United States Navy. The opinions and views set forth in this article are those of the writer and are not to be construed as reflecting the policies of the Navy Department. Nextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byChest PainFettverzehr-Plasmacholesterin-KoronarkrankheitThe Possible Relationship of the Emotions to Clinical Coronary Heart DiseaseComparison of Fat Intake of American Men and WomenPreliminary observations on some children with rheumatic heart disease transported to a subtropical climate 1 May 1945Volume 22, Issue 5Page: 639-652KeywordsArmed forcesCardiovascular therapyMedical communicationsSurgery ePublished: 1 December 2008 Issue Published: 1 May 1945 Copyright & PermissionsCopyright, 1945, by The American College of PhysiciansPDF downloadLoading ...
Health in China: The one child family policy: the good, the bad, and the ugly
Authors: T. Hesketh, W. X. Zhu
Journal: BMJ (1997)

Rapid population growth in China during the 1950s and '60s led to the "late, long, few" policy of the 1970s and a dramatic reduction in the total fertility rate. However, population growth remained too high for the economic targets of Deng Xiao Ping's reforms, so the one child family policy was introduced in 1979 and has remained in force ever since. The strategy is different in urban and rural areas, and implementation varies from place to place depending on local conditions. The policy has been beneficial in terms of curbing population growth, aiding economic growth, and improving the health and welfare of women and children. On the negative side there are concerns about demographic and sex imbalance and the psychological effects for a generation of only children in the cities. The atrocities often associated with the policy, such as female infanticide, occur rarely now. China may relax the policy in the near future, probably allowing two children for everyone.
Abstract 11838: The Hospital Volume-Outcome Relationship in Aortic Valve Surgery in the Elderly: An Analysis of Medicare-Fee-for-Service Patients From 2000-2009
Authors: Christian McNeely, Steve Markwell, Christina Vassileva
Journal: Circulation (2014)

Introduction:  The effect of volume on outcomes in cardiovascular and other surgeries has been documented. Still, there remains a lack of current data describing this effect in aortic valve replacement (AVR) on a national level. We examined outcomes among Medicare fee-for-service beneficiaries between 2000-2009 stratified by annual hospital procedural volume.   Methods and Results:  We used the Medicare database to identify 277,928 patients who underwent AVR from 2000-2009. Operative mortality and use of mechanical prostheses were analyzed according to hospital annual procedural volume. Mechanical valves were used in 64.5% of AVRs in hospitals with annual AVR volume  70. In general, mechanical valve use decreased with increasing hospital volume. After adjustment, the use of mechanical valves was independently associated with increased operative mortality HR=1.20 (95% CI 1.16-1.24) and reduced long-term survival (HR 1.05; 95% CI 1.04-1.06). The overall observed operative mortality rate was 7.3%, while for those undergoing isolated AVR the operative mortality rate was 5.5%. Lower volume hospitals exhibited increased adjusted operative mortality: ≤10 cases/year OR=1.51 (95% CI 1.36-1.68), 11-20 cases/year OR=1.31 (95% CI 1.20-1.43), 21-40 cases/year OR=1.13 (95% CI 1.04-1.23), 41-70 cases/year OR=1.08 (95% CI 1.00-1.19), relative to those hospitals performing >70 cases/year. The discrepancy in operative mortality between low and high-volume hospitals diverged during the course of the study.   Conclusions:  Low volume centers were characterized by increased adjusted operative mortality and greater use of mechanical prosthesis, a trend that persisted during the 10-year course of the study. These data would support the center of excellence concept for AVR and this may be particularly relevant in the elderly.
Medicare Drug Beneficiaries and Cost-Lowering Strategies—Reply
Authors: Chien-Wen Tseng, Carol M. Mangione
Journal: JAMA (2005)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Abstract 454: Mechanism of Alpha-Synuclein Inhibition of Platelet Granule Exocytosis
Authors: Kalyan Srivastava, Michael Lee, Craig Morrell
Journal: Circulation (2007)

Alpha-synuclein is only expressed in the brain and platelets. The normal function of alpha-synuclein in the brain is not known, but studies indicate it is an inhibitor of exocytosis in platelets. Platelet granule exocytosis is an important step in stable thrombus formation and its regulatory mechanisms are poorly defined. We therefore sought to determine the mechanism of alpha-synuclein inhibition of exocytosis. Using platelets from alpha-synuclein knockout (syn−/−) mice we first confirmed that syn−/− mice have increased alpha-granule release in response to agonist stimulation as compared to wild-type (WT) control mice. Using a mesenteric intravital microscopy model, we have also found that syn−/− mice have shortened time to thrombus formation as compared to wild-type control mice. The granule exocytosis and thrombosis phenotypic changes are restored to normal in syn null mice made transgenic to express human alpha-synuclein, clearly demonstrating that alpha-synuclein is an inhibitor of exocytosis in platelets. We have also determined the mechanism by which alpha-synuclein inhibits platelet granule exocytosis. Alpha-synuclein interacts with the exocytosis associated molecule Rab3, a modulator of the ATPase molecule N-ethylmaleimide Sensitive Factor (NSF). NSF activity is necessary for exocytosis and is increased by Rab3 interactions. Using platelet lysates, addition of an excess of recombinant alpha-synuclein inhibits NSF and Rab3 co-immunoprecipitation. Furthermore, syn−/− mouse platelets have increased Rab3 immunoprecipitation with NSF as compared to WT controls, that is restored to normal in synuclein Tg mice. Using recombinant tagged alpha-synuclein, NSF, and Rab3 in pull down assays we have confirmed that alpha-synuclein inhibits NSF-Rab3 interactions, and furthermore, decreases NSF ATPase activity. In summary, we now demonstrate using in vitro, ex vivo, and in vivo models that alpha-synuclein is a negative regulator of platelet granule exocytosis by inhibiting NSF-Rab3 association and thus NSF ATPase activity.
Cancer chemosensitivity prediction of drug combinations using single drug responses and microarray profiling data
Authors: Dmytro M. Havaleshko, HyungJun Cho, Jae K. Lee, Garret Hampton, Dan Theodorescu
Journal: Clinical Cancer Research (2006)

B46  Currently, the choice of therapy for metastatic cancer remains empiric due to the lack of chemosensitivity prediction for the available combination chemotherapeutic regimens. Here we present a novel approach that identifies chemosensitivity biomarker genes as predictors of tumor growth inhibition for three widely-used chemotherapeutic agents: Cisplatin, Paclitaxel, and Gemcitabine. Measuring cell proliferation responses 72hr after-treatment with each of these three agents on 40 human urothelial cancer cell lines, we obtained dose response curves and GI50 (50% of growth Inhibition) estimates. Based on these single drug response information and genome-wide gene expression profiling data of the 40 cell lines, we applied the MiPP (misclassification penalized posterior) approach, to discover molecular prediction models for these single drug responses. These MiPP-identified prediction models, each with a small number of gene biomarkers, predicted the responses of human bladder cancer cell lines to each of the three agents with a sensitivity of 0.93 to 0.96. Based only on these single-drug prediction models, we developed an in silico approach to predict responses to 3 clinically used two drug combinations of the aforementioned agents. We evaluated these predictions in vitro and found that 80% of 15 randomly-chosen cell lines were correctly predicted for their responsiveness to combination treatment (p=0.0002). Together, our results suggest for the first time that chemosensitivity to drug combinations can be accurately predicted based on gene expression profiling. Furthermore, this study provides the framework for the evaluation of predicted drug sensitivity in patients undergoing combination chemotherapy for cancer, based on gene expression profiles. If validated, this approach will lead to a breakthrough in personalized cancer therapy.
Abstract MP47: Contribution of Preventable Risk Factors for Incident Congestive Heart Failure in Older Adults: the Cardiovascular Health Study
Authors: Liana Del Gobbo, Shadi Kalantarian, Fumiaki Imamura, Rozenn Lemaitre, David Siscovick, Dariush Mozaffarian
Journal: Circulation (2014)

Background: Heart failure (HF) incurs high morbidity, mortality and health care costs among adults ≥65 years, the most rapidly growing segment of the US population. The relative contribution of lifestyle factors on incident HF, including total dietary pattern, physical activity, smoking, alcohol, and obesity, has not been established. Methods: We prospectively investigated the contribution of major preventable risk factors, measured using repeated assessments, on incident HF among 4490 men and women ≥65 years in the Cardiovascular Health Study, a community-based US cohort. Lifestyle factors included four diet patterns (Biologic, DASH, AHEI, AHA 2020), four physical activity metrics (exercise intensity, walking pace, walking distance leisure activity), alcohol intake, smoking, and obesity. Incident HF was adjudicated by a centralized committee using medical records, diagnostic tests, and interviews. Adults with baseline CHF, moderate or severe mitral or aortic regurgitation, or missing lifestyle information were excluded from analysis. Risk associated with each lifestyle factors was assessed using Cox proportional hazards models. Results: Over 21-years (51849 person-years), 1380 cases of HF occurred. After multivariable adjustment, no dietary pattern was associated with incident HF ( p &gt;0.05), although sodium intake was associated with increased risk in secondary analyses. In contrast, walking pace, leisure activity, modest alcohol intake, former or never smoking, and BMI&lt;30kg/m 2 were independently associated with lower risk of HF, with the highest population attributable risks for alcohol intake (18%) and physical activity (18%), followed by BMI (8%) and smoking (5%) (Table). Conclusion: Surprisingly, overall dietary patterns were not associated with HF, although sodium intake was associated with increased risk. Key modifiable risk factors to be targeted for HF prevention in older adults include physical activity and alcohol intake, obesity and smoking.
Bergey's Manual of Systematic Bacteriology
Authors: in chief George M. Garrity
Journal: Annals of Internal Medicine (1990)

BCL3 and Sheehy cite Bergey's manual of determinative bacteriology of which systematic bacteriology, first edition, is an expansion. With v.4 the set is complete. The volumes cover, roughly, v.1, the Gram-negatives except those in v.3 ($87.95); v.2, the Gram-positives less actinomycetes ($71.95); v.
Mild Hyperthyroidism and the Neuroses
Authors: Philip S. Smith
Journal: Annals of Internal Medicine (1931)

Article1 May 1931Mild Hyperthyroidism and the NeurosesPHILIP S. SMITH, M.D., F.A.C.P.PHILIP S. SMITH, M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-4-11-1460 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptNo apology will be made for bringing to your attention a subject so frequently discussed in recent years as hyperthyroidism. Until the essential facts, both physiologic and pathologic, are more completely understood, the theme is not inappropriate for further study.The caption of the paper suggests the limitations of the subject to be considered. That a well-defined and advanced hyperthyroidism presents no difficulty in diagnosis is indicated by the fact that pupil nurses frequently classify the patient upon admission to the hospital before the preliminary notes are made by the interns. In these patients thorough clinical investigation merely confirms the...References1 SMITH PS: Lowered Metabolic Rates, with Special Reference to Young Women. Sou. Med. Jour., Oct., 1926. CrossrefGoogle Scholar2 SMITH JH: The Basal Metabolic Rate in Relation to Symptoms and Signs in Hyperthyroidism. Arch. Int. Med., Vol. 41; 96, June, 1928. CrossrefGoogle Scholar3 BOOTHBY WM: Diagnosis and Treatment of Diseases of the Thyroid. Oxford Med. Vol. 3. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Abingdon, Va.*Read by invitation before the Alleghany-Bath Medical Society, Clifton Forge, Va., September 19th, 1930.†From the Johnston Memorial Clinic, Abingdon, Virginia. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 May 1931Volume 4, Issue 11Page: 1460-1468KeywordsHyperthyroidism ePublished: 1 December 2008 Issue Published: 1 May 1931 PDF downloadLoading ...
Arm Ischemia and Posterior Stroke in a Patient With a Pulsatile Mass in the Right Upper Side of Chest
Authors: Maham Rahimi, Jonathan Bath
Journal: JAMA Surgery (2015)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Surgery HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Surgery journal