Hypomagnesemic Hypocalcemia Independent of Parathyroid Hormone
Authors: MARK L. GRABER
Journal: Annals of Internal Medicine (1986)

Brief Reports1 June 1986Hypomagnesemic Hypocalcemia Independent of Parathyroid HormoneMARK L. GRABER, M.D., GERALD SCHULMAN, M.D.MARK L. GRABER, M.D.Search for more papers by this author, GERALD SCHULMAN, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-104-6-804 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptHypocalcemia, common in patients with magnesium depletion, has been attributed to either defective release of parathyroid hormone, resistance to the hormone's peripheral effects, or a combination of the two (1). We report a case that suggests that this hypocalcemia may simply represent a direct effect of magnesium depletion on bone independent of the effects of parathyroid hormone. A 68-year-old man presented with a thyroid mass. A biopsy specimen showed recurrence of a squamous cell carcinoma of a vocal cord that had been removed 4 years previously. His nutritional status was normal, as were all electrolyte determinations, including plasma concentrations of...References1. MASSRY S. Pharmacology of magnesium. Annu Rev Pharmacol Toxicol. 1977;17:67-82. CrossrefMedlineGoogle Scholar2. WHANGAIKAWA RJ. Magnesium deficiency and refractoriness to potassium repletion. J Chronic Dis. 1977;30:65-8. CrossrefMedlineGoogle Scholar3. HOME L. Hypoparathyroidism requiring massive amounts of medication with apparent response to magnesium sulfate. J Clin Endocrinol Metab. 1961;21:219-23. CrossrefMedlineGoogle Scholar4. ROSLERRABINOWITZ AD. Magnesium-induced reversal of vitamin-D resistance in hypoparathyroidism. Lancet. 1973;1:803-4. CrossrefMedlineGoogle Scholar5. MEDALLEWATERHOUSEHAHN RCT. Vitamin D resistance in magnesium deficiency. Am J Clin Nutr. 1976;29:854-8. CrossrefMedlineGoogle Scholar6. DURANBORSTOSBURNEEIL MGRC. Concurrent renal hypomagnesemia and hypoparathyroidism with normal parathormone responsiveness. Am J Med. 1984;76:151-4. CrossrefMedlineGoogle Scholar7. REDDYSIVAKUMAR VB. Magnesium-dependent vitamin-D-resistant rickets. Lancet. 1974;1:963-5. CrossrefMedlineGoogle Scholar8. RAISZNIEMANN LJ. Effect of phosphate, calcium, and magnesium on bone resorption and hormonal responses in tissue culture. Endocrinology. 1969;85:446-52. CrossrefMedlineGoogle Scholar9. MACMANUSHEATON JF. The influence of magnesium on calcium release from bone in vitro. Biochim Biophys Acta. 1970;215:360-7. CrossrefMedlineGoogle Scholar10. PAKDILLER CE. Ionic interaction with bone mineral. V. Effect of Mg2+, Citrate 3-, F- and SO4 negative 2 ion on the solubility, dissolution and growth of bone mineral. Calcif Tissue Res. 1969;4:69-77. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Veterans Administration Medical Center Northport, New York State University of New York Stony Brook, New York PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited BySensing mechanisms involved in Ca2+ and Mg2+ homeostasisMagnesium HomeostasisMagnesium Intake from Food and Supplements Is Associated with Bone Mineral Density in Healthy Older White SubjectsMagnesium HomeostasisMagnesium Deficiency in Parathyroid FunctionHypocalcaemia and chronic alcohol intoxication: Transient hypoparathyroidism secondary to magnesium deficiencyDisorders of Magnesium MetabolismMagnesium deficiency: Pathophysiologic and clinical overviewMagnesium deficiency enhances basal glucose disposal in the ratPrimary infantile hypomagnesaemia: Report of two casesAssessment of Hypocalcemia and HypercalcemiaCase Report: Hypoparathyroidism with Menses-Associated HypocalcemiaMagnesium deficiency: Recognition and treatment in the emergency medicine settingMyocardial magnesium: Relation to laboratory and clinical variables in patients undergoing cardiac surgeryDie Hypomagnesiaemie-bedingte Hypocalciaemie: Funktioneller Hypoparathyreoidismus, Parathormon- und Vitamin D-ResistenzMineral MetabolismContinuing medical education articleMagnesium metabolism in health and diseaseResistance to Calcitriol Therapy in Postsurgical HypoparathyroidismURIEL S. BARZEL, M.D. 1 June 1986Volume 104, Issue 6Page: 804-805KeywordsAttentionBiopsyBlood plasmaBoneHypocalcemiaMagnesiumNutritionParathyroid hormoneSquamous cell carcinomaThyroid Issue Published: 1 June 1986 PDF DownloadLoading ...