THE TREATMENT OF ADDISON'S DISEASE WITH SODIUM COMPOUNDS, WITH THE REPORT OF ONE CASE AND THE SUMMARIES OF ELEVEN OTHER COLLECTED CASES THUS TREATED
Authors: Edward C. Reifenstein
Journal: Annals of Internal Medicine (1936)

Article1 April 1936THE TREATMENT OF ADDISON'S DISEASE WITH SODIUM COMPOUNDS, WITH THE REPORT OF ONE CASE AND THE SUMMARIES OF ELEVEN OTHER COLLECTED CASES THUS TREATEDEDWARD C. REIFENSTEIN, M.D., F.A.C.P., EDWARD C. REIFENSTEIN JR., M.D.EDWARD C. REIFENSTEIN, M.D., F.A.C.P.Search for more papers by this author, EDWARD C. REIFENSTEIN JR., M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-9-10-1338 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe treatment of Addison's disease has undergone a marked change in the last five years. Ever since 1855, when Addison first described the insufficiency disease of the suprarenal cortex that now bears his name, investigators have been trying to devise an adequate treatment for this condition.MUIRHEAD RÉGIMEPrevious to 1930, physicians relied chiefly on the Muirhead régime,1which consisted of administering epinephrine by mouth, by rectum, and subcutaneously at frequent intervals and up to the patient's tolerance, together with "desiccated cortex" by mouth, 10 to 15 grains daily. Results from this regimen were observed in 10 to 20 per...References1. MUIRHEAD AL: Autograph history of case of Addison's disease, Jr. Am. Med. Assoc., 1921, lxxvi, 652. Google Scholar2. SWINGLEPFIFFNER WWJJ: The revival of comatose adrenalectomized cats with an extract of the suprarenal cortex, Science, 1930, lxxii, 75. CrossrefGoogle Scholar3. HARTMANBROWNELL FAKA: The hormone of the adrenal cortex, Science, 1930, lxxii, 76. CrossrefGoogle Scholar4. SNELL AM: Diagnosis and treatment of Addison's disease with reference to series of 46 patients treated with suprarenal cortical hormone, Internat. Clin., 1934, iii, 46-62. Google Scholar5. STEWART GN: Adrenalectomy and relation of adrenal bodies to metabolism, Physiol. Rev., 1924, iv, 163-190. CrossrefGoogle Scholar6. STEWARTROGOFF GNJM: Studies on adrenal insufficiency, Proc. Soc. Exper. Biol. and Med., 1925, xxii, 394-397. CrossrefGoogle Scholar7. BANTINGGAIRNS FGS: Suprarenal insufficiency, Am. Jr. Physiol., 1926, lxxvii, 100-113. CrossrefGoogle Scholar8. LUCAS GH: Blood and urine findings in desuprarenalized dogs, Am. Jr. Physiol., 1926, lxxvii, 114-125. CrossrefGoogle Scholar9. COREY EL: Effect of forcing fluids upon survival after bilateral epinephrectomy, Am. Jr. Physiol., 1927, lxxix, 633-640. CrossrefGoogle Scholar10. ZWEMER RL: Experimental study of adrenal cortex. II. Prolongation of life after complete epinephrectomy, Am. Jr. Physiol., 1927, lxxix, 658-665. CrossrefGoogle Scholar11. BAUMANNKURLAND EJS: Changes in inorganic constituents of blood in suprarenalectomized cats and rabbits, Jr. Biol. Chem., 1927, lxxi, 281-302. CrossrefGoogle Scholar12. MARINEBAUMANN DEJ: Duration of life after suprarenalectomy in cats, and attempts to prolong it by injections of solutions containing sodium salts, glucose, and glycerol, Am. Jr. Physiol., 1927, lxxxi, 86-100. CrossrefGoogle Scholar13. LOEB RF: Chemical changes in blood in Addison's disease, Science, 1932, lxxvi, 420-421. CrossrefGoogle Scholar14. BUTLERTUTHILL AME: An application of the uranyl zinc acetate method for determination of sodium in biological material, Jr. Biol. Chem., 1931, xciii, 171-180. CrossrefGoogle Scholar15. ATCHLEYBENEDICT DWEM: Serum electrolyte studies in normal and pathological conditions: pneumonia, renal edema, cardiac edema, uremic and diabetic acidosis, Jr. Clin. Invest., 1930, ix, 265-294. CrossrefGoogle Scholar16. LOEBATCHLEYBENEDICTLELAND RFDWEMJ: Electrolyte balance studies in adrenalectomized dogs with particular reference to excretion of sodium, Jr. Exper. Med., 1933, lvii, 775-792. CrossrefGoogle Scholar17. HARROPSOFFERELLSWORTHTRESCHER GALJRJH: Studies on suprarenal cortex. III. Plasma electrolytes and electrolyte excretion during suprarenal insufficiency in dog, Jr. Exper. Med., 1933, lviii, 17-38. CrossrefGoogle Scholar18. LOEB RF: Effect of sodium chloride in treatment of patient with Addison's disease, Proc. Soc. Exper. Biol. and Med., 1933, xxx, 808-812. CrossrefGoogle Scholar19. LOEBATCHLEY RFDW a. : Significance of salt in treatment of Addison's disease, Med. Clin. N. Am., 1934, xvii, 1317-1323. b. LOEB, R. F., ATCHLEY, D. W., and STAHL, J.: Rôle of sodium in adrenal insufficiency, Jr. Am. Med. Assoc., 1935, civ, 2149-2154. Google Scholar20. LOEBATCHLEYGUTMANJILLSON RFDWEBR: On mechanism of sodium depletion in Addison's disease, Proc. Soc. Exper. Biol. and Med., 1933, xxxi, 130-133. CrossrefGoogle Scholar21. HARROPWEINSTEINSOFFERTRESCHER GAALJJH: Diagnosis and treatment of Addison's disease, Jr. Am. Med. Assoc., 1933, c, 1850-1855. CrossrefGoogle Scholar22. SEARS WG: Case of Addison's disease treated with common salt, Lancet, 1934, i, 950-951. CrossrefGoogle Scholar23. SNELL AM: Addison's disease of unusually long duration, Proc. Staff Meet. Mayo Clin., 1934, ix, 303-307. Google Scholar24. HOWELL CM: Effects of common salt in Addison's disease, Lancet, 1934, i, 1116-1117. CrossrefGoogle Scholar25. NETTROURRYNEARSON WSEH: Salt-poor diet as provocative test for Addison's disease, Proc. Staff Meet. Mayo Clin., 1934, ix, 550-556. Google Scholar26. TOUWNOORDHOEK HEGT JFWF: Treatment of Addison's disease with sodium chloride, Nederl. Tijdschr. v. Geneesk., 1934, lxxviii, 4439-4446. Google Scholar27. WILDER RM: Use of anterior lobe pituitary extract in treatment of Addison's disease, Proc. Staff Meet. Mayo Clin., 1934, ix, 689-693. Google Scholar28. CROOKERUSSELL ACDS: Pituitary gland in Addison's disease, Jr. Path. and Bact., 1935, xl, 255-283. CrossrefGoogle Scholar29. GAMBLEROSSTISDALL JLGSFF: Metabolism of fixed base during fasting, Jr. Biol. Chem., 1923, lvii, 633-695. CrossrefGoogle Scholar30. ATCHLEYLOEBRICHARDSBENEDICTDRISCOLL DWRFDWEMME: On diabetic acidosis; a detailed study of electrolyte balances following the withdrawal and reëstablishment of insulin therapy, Jr. Clin. Invest., 1933, xii, 297-326. CrossrefGoogle Scholar31. FØLLING A: On mechanism of ammonium chloride acidosis, Acta. med. Skandinav., 1929, lxxi, 221-279. Google Scholar32. ZWEMER RL: Adrenal cortex and electrolyte metabolism, Endocrinology, 1934, xviii, 161-169. CrossrefGoogle Scholar33. BLANKENHORNHAYMAN MAJM: Note on use of suprarenal extract and sodium salts in case of Addison's disease, Am. Jr. Med. Sci., 1935, clxxxix, 419-423. CrossrefGoogle Scholar34. RUBINKRICK MIET: Effect of adrenalectomy on salt metabolism in rats, Proc. Soc. Exper. Biol. and Med., 1933, xxxi, 228-229. CrossrefGoogle Scholar35. GAUNTTOBINGAUNT RCEJH: Effect of high salt diet on survival of adrenalectomized rats, Proc. Soc. Exper. Biol. and Med., 1934, xxxii, 134-136. CrossrefGoogle Scholar36. SWINGLEPFIFFNERVARSPARKINS WWJJHMWM: The effect of sodium chloride administration upon adrenalectomized dogs not receiving extract, Am. Jr. Physiol., 1934, cviii, 159-167. CrossrefGoogle Scholar37. Editorial: Common salt for Addison's disease, Lancet, 1934, i, 137. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: EDWARD C. REIFENSTEIN, M.D., F.A.C.P.; EDWARD C. REIFENSTEINJR., M.D.Affiliations: Syracuse, N. Y.*Received for publication October 1, 1935.From the Medical Service of the University Hospital, and the Department of Medicine of the Syracuse University College of Medicine. 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