tbuckley/cabot-search huggingface dataset:
Abstract MP28: Heart Rate At Hospital Discharge Is Associated With Adverse Long Term Outcomes In Patients With Heart Failure
Authors: Ihab B Alomari, Xin Zhao, Adrian F Hernandez, Zubin J Eapen, Gregg C Fonarow, Clyde W Yancy, Paul A Heidenreich, Deepak L Bhatt, Warren K Laskey
Journal: Circulation (2014)

Background: Heart rate (HR) has been identified as a risk factor for adverse long-term outcomes in patients with and without heart disease. However, the relationship between discharge HR and outcomes in patients receiving guideline based therapy for HF remains unknown. Hypothesis: Heart rate at hospital discharge in patients with HF is an independent predictor of mortality and readmission rates at 1 year. Methods: Using the American Heart Association Get With The Guidelines Heart Failure national quality assurance registry linked with Medicare data, long term outcomes for patients ≥65 years of age hospitalized from 2005-2011 were obtained. Univariable and multivariable analyses were performed to examine the relationship between 1-year outcomes (death or all cause readmission) and discharge HR. Heart rate was analyzed as a categorical (tertiles) or continuous variable. Crude and adjusted odds ratios and 95% confidence intervals for the association between discharge HR and the risk of death or hospitalization by 1-year were obtained from logistic regression modeling. Results: The analysis sample was comprised of 45,672 patients with a valid link to Medicare data and 1 year outcome status. The mean age was 80 ±8 years; % male was 45.7; and the mean ejection fraction was 43.5 ±16. Median discharge HRs for the first, second and third tertiles significantly differed (61, 72 and 87 bpm, respectively, p &lt;0.0001). In univariable and multivariable analyses adjusted for clinical and hospital level variables there was a statistically significant relationship between 1 year outcomes and discharge HR (Table). Conclusion: In hospitalized patients with HF, HR at the time of discharge is an independent predictor of mortality. Despite optimal adherence to current guideline based therapy, the odds for all-cause mortality increased by 13% for every 10 beat increases in HR. The use of HR both as a prognostic variable, as well as potentially modifiable risk factor, may be of value in risk-stratification algorithms at discharge.
Abstract 57: Blood parameters in renal cell carcinoma patients can have prognostic impact and differ from those of healthy blood donors
Authors: Steffen Goebel, Karen Bluemke-Anbau, Wolfgang Altermann, Udo Bilkenroth, Axel Meye, Susanne Fuessel, Christine Lautenschlaeger, Andres Melchior, Hans Heynemann, Paolo Fornara, Helge Taubert
Journal: Cancer Research (2014)

Abstract The aim of this study was to evaluate the clinical relevance of blood parameters as circulating tumor cells (CTCs) and HLA subtype in renal cell carcinoma (RCC) patients. 233 peripheral blood samples from 154 RCC patients were tested for the presence of disseminated tumor cells (DTCs) by using the autoMACS technique and immunocytochemical (ICC) staining of cytokeratin. The frequency of CTCs was analyzed statistically and correlated with relevant clinical data. In addition, HLA subtype was analysed for 91 out of the 154 RCC patients and for 203 healthy blood donors. A statistical comparison was performed. After following the CD45 autoMACS depletion protocol, we identified CTCs in 96 out of 233 peripheral blood samples (41%), which originated from 81 out of 154 (53%) RCC patients. Besides a significant correlation between the detection of CTCs before and after primary tumor resection a significant association with prognosis was found (p &amp;lt; 0.002; X2-test). RCC patients with CK+ CTCs in their peripheral blood had a 5 times increased risk of tumor-related death compared to patients without these cells. In a Kaplan-Meier-Analysis these results were confirmed (p &amp;lt; 0.001). On one hand, RCC patients had less alleles HLA-Cw*07 (p &amp;lt; 0.05; X2-test) and HLA-DRB1*04 (p &amp;lt; 0.05; X2-test) compared to healthy blood donors. On the other hand, RCC patients showed an increased occurrence of the allele HLA-Cw*12 compared to healthy blood donors. However, this difference was not significant. In summary, for RCC patients the presence of CTCs was associated with a poor overall survival and significantly correlated with an increased risk of tumor-related death. Detection of CK+ CTCs in peripheral blood is a significant and independent prognostic factor for renal cell carcinoma patients. Occurrence of the alleles HLA-Cw*07, and HLA-DRB1*04 was significantly reduced in RCC patients compared to healthy blood donors and may reduce the risk to suffer from a RCC. Citation Format: Steffen Goebel, Karen Bluemke-Anbau, Wolfgang Altermann, Udo Bilkenroth, Axel Meye, Susanne Fuessel, Christine Lautenschlaeger, Andres Melchior, Hans Heynemann, Paolo Fornara, Helge Taubert. Blood parameters in renal cell carcinoma patients can have prognostic impact and differ from those of healthy blood donors. [abstract]. In: Proceedings of the 105th Annual Meeting of the American Association for Cancer Research; 2014 Apr 5-9; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2014;74(19 Suppl):Abstract nr 57. doi:10.1158/1538-7445.AM2014-57
FOLLICULAR LYMPHOMA (BRILL-SYMMERS DISEASE) UNSUCCESSFULLY TREATED WITH PENICILLIN: A CASE REPORT
Authors: Norman W. Drey, Frank B. Queen
Journal: Annals of Internal Medicine (1945)

Case Reports1 December 1945FOLLICULAR LYMPHOMA (BRILL-SYMMERS DISEASE) UNSUCCESSFULLY TREATED WITH PENICILLIN: A CASE REPORTNORMAN W. DREY, FRANK B. QUEENNORMAN W. DREYSearch for more papers by this author, FRANK B. QUEENSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-23-6-1009 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptFollicular lymphoma (Brill-Symmers disease) is a neoplastic disease of the lymphoid tissues.1The average age of onset is 50, the sexes are equally affected, the tumor is localized in approximately 10 per cent of cases, and is responsive to radiation therapy in 95 per cent of cases. It is the least malignant of the malignant lymphoma group, and offers arelativelyfavorable prognosis as judged by the five-year survival rate of 53 per cent. Nevertheless, the 10 year survival rate is but 16 per cent—only twice that of Hodgkin's lymphoma. The eventual fatal outcome of those surviving 10 years, and...Bibliography1. GALLMALLORY EATB: Malignant lymphoma. A clinico-pathologic survey of 618 cases, Am. Jr. Path., 1942, xviii, 381-429. Google Scholar2. GALL EA: The surgical treatment of malignant lymphoma, Ann. Surg., 1943, cxviii, 1064-1070. CrossrefGoogle Scholar3. CORNMAN I: Survival of normal cells in penicillin solutions lethal to malignant cells, Science, 1944, xcix, 247. CrossrefGoogle Scholar4. ROBINSON HJ: Toxicity and efficacy of penicillin, Jr. Pharmacol. and Exper. Therap., 1943, lxxvii, 70-79. Google Scholar5. HERRELLHEILMAN WEDH: Tissue culture studies on cytoxicity of bactericidal agents, Am. Jr. Med. Sci., 1943, ccv, 157-162. CrossrefGoogle Scholar6. CHAINFLOREYGARDNERJENNINGSORR-EWINGSANDERSHEATLEY EHWADMAJAFNG: Penicillin as a chemotherapeutic agent, Lancet, 1940, ii, 226-228. CrossrefGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: *Received for publication October 13, 1944.†In 23 per cent there is failure of persistence of histologic type as determined by successive biopsies—i.e., there is dedifferentiation and transition into a lymphoma of more malignant type as the disease progresses. This is evidence for the belief that all the lymphomas are tumors essentially of common origin.1 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byGIANT FOLLICLE HYPERPLASIA: A STUDY OF ITS INCIDENCE, HISTOPATHOLOGIC VARIABILITY, AND THE FREQUENCY OF SARCOMA AND SECONDARY HYPERSPLENIC COMPLICATIONS*THEODORE S. EVANS, M.D., F.A.C.P., CHARLES A. DOAN, M.D., F.A.C.P. 1 December 1945Volume 23, Issue 6Page: 1009-1015KeywordsHodgkin lymphomaLymphomaPenicillinRadiation therapy ePublished: 1 December 2008 Issue Published: 1 December 1945 PDF downloadLoading ...
Abstract 68: Tumor operational signaling pathways in an Nf1 mutant mouse model system
Authors: Steve Braunstein, Rana Mroue, Brian Huang, Sourav Bandyopadhyay, Jean Nakamura
Journal: Cancer Research (2014)

Abstract Purpose/Objectives: NF1 is recognized as a tumor suppressor, via its role as a Ras GTPase activating protein. However, the precise mechanisms critical to tumor development in NF1 patients remain unclear. NF1 heterozygosity confers susceptibility to tumorigenesis, promoted by genotoxins such as radiation. We mutagenized Nf1 heterozygous mice using radiation to generate a diverse panel of Nf1 null tumors. Using these novel reagents we interrogated signaling pathways essential for tumor development and propagation towards identification of potential targets for therapeutic approaches. Materials/Methodology: Cell lines were derived from solid tumors developing after focal irradiation of Nf1 heterozygous mice. Radiation-induced tumors included mammary carcinomas, squamous carcinomas, and sarcomas. We employed a high-throughput toxicity screen of 94 conventional and targeted FDA-approved chemotherapeutics directed across diverse core cellular signaling pathways. Drug sensitivity profiles were determined by quantifying cell numbers after a 72 hour drug exposure, and tumor cell lines, non-transformed wild-type and Nf1 null MEFs, and mutant Ras-transformed cell lines (added as controls) were compared. Validation of identified drug sensitivities was performed by enzyme activity assays, phosphoprotein analysis, and soft-agar colony formation. Results: Nf1 mutant tumors failed to demonstrate a common drug sensitivity signature, but instead revealed a heterogeneous pattern of differential sensitivities, with subgroups clustering independent of tumor histology. However, radiation-induced Nf1 null tumor lines exhibited increased sensitivity to inhibition of the Ras-Erk and PI3K-mTOR axis as compared to non-transformed controls. Enhanced sensitivity to agents targeting cell cycle and survival pathways was also observed selectively within the Nf1 null tumor cell lines. Conclusions: These studies indicate that Nf1 null tumors, even those of the same histology, do not intrinsically share a signature sensitivity profile to pharmacologic inhibition. This suggests that therapeutic targeting of signaling pathways in Nf1 mutant tumors is not likely to be defined strictly by Nf1 loss alone. Notably, these Nf1 null tumors evidence varied operational dependence upon PI3K-mTOR and Raf-MEK activity. Current efforts are directed towards further resolving essential mediators, with the goal of more precisely defining signaling pathways which drive progression of the malignant state. Citation Format: Steve Braunstein, Rana Mroue, Brian Huang, Sourav Bandyopadhyay, Jean Nakamura. Tumor operational signaling pathways in an Nf1 mutant mouse model system. [abstract]. In: Proceedings of the 105th Annual Meeting of the American Association for Cancer Research; 2014 Apr 5-9; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2014;74(19 Suppl):Abstract nr 68. doi:10.1158/1538-7445.AM2014-68
Abstract 15348: Higher Mortality in Patients with Undiagnosed Hypertension: Is the Electronic Medical Record the Key to Their Identification?
Authors: Olufunso W Odunukan, Stephen Cha, Parvez A Rahman, Daniel Roellinger, Mark A Nyman
Journal: Circulation (2014)

Introduction: Patients with hypertension (HTN) may remain undiagnosed as the diagnosis requires systolic blood pressure (SBP) ≥ 140 mmHg or diastolic blood pressure (DBP) ≥ 90 mmHg on ≥ 2 different occasions. Hypothesis: We sought to evaluate outcomes of patients without diagnosed hypertension who have elevated BP meeting current thresholds for hypertension on 2 consecutive episodes. Methods: Together with retrospective billing and clinical data, electronic records of all outpatient visits in 2009 were used to identify 24,277 patients with 2 consecutive visits (2CHBP) with SBP ≥ 140mmHg or DBP ≥ 90 mmHg and were compared with a previously identified cohort of 53,998 known hypertension patients. Among the 2CHBP group, 6,071 (25%) were identified without a prior diagnosis of hypertension and were categorized as undiagnosed hypertension. They were compared with patients with known hypertension who had ≥ 1 visit in 2009. Cross-sectional analysis of cardiovascular comorbidities and proportional hazards for survival were done. Results: Of 5,978 undiagnosed HTN patients, 49% were female compared to 51% of 10,311 known HTN. In the undiagnosed HTN group, 19.5% were ≥ 80 years compared to 30.4% of known HTN patients. Cardiovascular comorbidities were generally lower in the undiagnosed HTN group compared to the known HTN group - heart failure (7% v 8%; OR 0.88, 95% CI: 0.77 - 0.99; p &lt; 0.038), atrial fibrillation (11% v 12%, OR 0.88 95% CI 0.79 - 0.97) and coronary artery disease (17% v 26%, OR 0.57 95% CI 0.52 - 0.61). However after a four year followup, mortality was higher in the undiagnosed HTN group with unadjusted hazard ratio HR 1.4 (95% CI 1.29 - 1.60, p&lt;0.0001) and HR 2.41 (2.16 -2.68, p&lt;0.0001) when adjusted for age, sex, heart failure and diabetes. Conclusions: Over a quarter of patients meeting current thresholds on 2 consecutive visits did not carry a known diagnosis of hypertension. Although younger and with less cardiovascular comorbidities than those with diagnosed hypertension, mortality after 4 years was significantly higher in those with undiagnosed hypertension. Electronic records can be used to identify these high risk patients.
Long-term effectiveness and safety of pravastatin in 9014 patients with coronary heart disease and average cholesterol concentrations: the LIPID trial follow-up
Authors: R. J. Simes, D. Hunt, A. Kirby, A. Tonkin, A. Keech, P. Aylward, D. Colquhoun, P. Glasziou, W. Hague, Stephen MacMahon
Journal: The Lancet (2002)
Hong Kong wants adults to save for their health care in old age
Authors: Jane Parry
Journal: BMJ (2001)

The Hong Kong government has been criticised from all sides for its wide ranging proposals for healthcare reform, not least because it wants all working adults to save towards their medical care in old age.

The idea was mooted in the green paper Lifelong Investment in Health , for which the public consultation period ended on 31 March. It addressed three main issues—health care delivery, quality assurance, and funding and financing for healthcare services.

The Health Protection Account was one of the central financing proposals. It would require all working adults aged 40 to 65 to save 1% or 2% of their income to contribute towards the cost of medical services after the age of 65.

Among …
Scleral rupture during retinal detachment surgery: risk factors, management options, and outcomes11Dr. Tabandeh is currently affiliated with the Department of Ophthalmology, University of Florida, Gainesville, Florida. Dr. Flaxel is affiliated with the Doheny Eye Institute, University of Southern California, Los Angeles, California.
Authors: Homayoun Tabandeh, Christina Flaxel, Paul M Sullivan, Peter K Leaver, Harry W Flynn, Joyce Schiffman
Journal: Ophthalmology (2000)
Prednisone and azathioprine compared with prednisone and placebo for treatment of chronic graft-v-host disease: prognostic influence of prolonged thrombocytopenia after allogeneic marrow transplantation
Authors: KM Sullivan, RP Witherspoon, R Storb, P Weiden, N Flournoy, S Dahlberg, HJ Deeg, JE Sanders, KC Doney, FR Appelbaum
Journal: Blood (1988)
Physical activity during adulthood and adolescence in relation to renal cell cancer
Authors: Steven Moore, Wong-Ho Chow, Arthur Schatzkin, Kenneth Adams, Yikyung Park, Rachel Ballard-Barbash, Albert Hollenbeck, Michael Leitzmann
Journal: Cancer Research (2008)

3093     Background:   Evidence for a relationship between physical activity and renal cell cancer has been inconsistent.    Methods:   We examined physical activity in relation to renal cell cancer in a cohort of 499,437 participants (297,926 men and 201,511 women) aged 50-71 at study baseline from the National Institutes of Health-AARP Diet and Health Study. At baseline (1995-1996), participants completed a questionnaire inquiring about current frequency of exercise/ sports activities of at least 20 minutes duration, intensity of daily routine activity, and frequency of activity during adolescence (between ages 15 and 18). Cox regression was used to estimate relative risks (RR) and 95% confidence intervals (95% CI). During up to 8.2 years of follow-up, 1,267 cases were ascertained (945 in men and 322 in women).    Results:   In multivariate models adjusted for renal cell cancer risk factors (i.e. gender, age, race, smoking, BMI, height, history of diabetes, history of hypertension, and protein intake) we observed that current exercise/ sports, routine physical activity, and activity during adolescence were associated with a reduced risk of renal cell cancer. The multivariate RRs of the highest activity level as compared with the lowest activity level were 0.76 (95% CI: 0.63, 0.91, P  trend =0.08) for exercise/ sports, 0.85 (95% CI: 0.58, 1.23, P  trend =0.02) for routine physical activity, and 0.82 (95% CI: 0.68, 0.99, P  trend =0.03) for activity during adolescence. Assuming a causal relationship, our data suggest that 10% of renal cell cancers would be prevented if all persons exercised three or more times per week for 20 or more minutes and engaged in light or moderate routine activities, as recommended by public health guidelines.    Conclusion:   Increased physical activity, including activity during adolescence, is associated with reduced risk of renal cell cancer.
726. Ultrasound Enhances Retroviral-Mediated Gene Transfer
Authors: David M. Markusic, Ronald Oude-Elferink, Jurgen Seppen
Journal: Molecular Therapy (2004)

Lentiviral vectors transduce quiescent cells, exhibit stable genomic integration, and provide long-term expression. These properties make them ideal gene delivery vehicles for the treatment of inherited liver diseases. In vivo studies using vesicular stomatits virus g protein (VSVg) pseudotyped lentiviral vectors have low transduction efficiency in hepatocytes. The broad tropism of VSVg pseudotyped lentiviral vectors present problems for in vivo studies where gene transfer should be restricted to a specific tissue and the transduction of professional antigen presenting cells (APC) may accelerate the clearance of transduced cells by the immune system. Past attempts to redirect viral tropism through modification of the viral envelope protein have proven to be unsuccessful. To improve the transduction efficiency of hepatocytes we investigated the targeting of lentiviral vectors to the liver by using an alternative envelope protein. We needed to find an envelope protein that gives high titer virus that can be concentrated without significant loss of titer. There are several viral envelope proteins reported in literature to give a liver tropism, but to date none are capable of producing the high titer, stable virus particles needed for in vivo studies.
Abstract 18295: Racial and Insurance Disparities in Atrial Fibrillation Ablation
Authors: Nileshkumar J Patel, Abhishek Deshmukh, Achint Patel, Neil Patel, Badal Thakkar, Shilpkumar Arora, Nilay Patel, Vinaykumar Panchal, Apurva O Badheka, Marcin Kowalski, Hakan Paydak, Juan F Viles Gonzalez, Robert J Myerburg, Raul D Mitrani
Journal: Circulation (2014)

Objective: To identify possible racial and/or health insurance disparities with respect to ablation procedures for atrial fibrillation (AF). Method: Using the Nationwide Inpatient Sample (2000-2011), we identified adult patients (pts) admitted with principle diagnosis of AF by ICD 9 code 427.31 who had catheter ablation (ICD 9 code - 37.34). We stratified patients by race (White, Black, Hispanic, and other minority racial groups), insurance status, age, gender, type of hospital, and type of hospital admission. A hierarchical mixed effect multivariate model was created to identify independent predictors of AF ablation. Results: Among 4,547,144 patients hospitalized with AF during the study period, 201,447(4.43%) underwent ablation procedures. In absolute numbers, the majority of the ablations were performed in Whites (65.7%) and patients with Medicare (66.7%) or private insurance (24.7%). After adjusting for confounding factors, the proportions of Black pts (compare to White), and Medicare, Medicaid, and Uninsured pts (compare to private insurance), receiving ablation therapy were lower (see table). Odds of having ablation were lower in older and female patients and higher in teaching hospitals and after elective admissions (p&lt;0.001 for all comparisions). Similar racial and insurance disparities were observed over the time course of the study. Conclusion: We identified lower rates of AF ablation among black pts even after correction of other factors such as insurance. Ablation rates were also lower among patients without private insurance. These trends persisted during the study period of 2000-2011.
Chronic myelomonocytic leukemia: 2013 update on diagnosis, risk stratification, and management
Authors: Sameer A. Parikh, Ayalew Tefferi
Journal: American Journal of Hematology (2013)

Disease overview Chronic myelomonocytic leukemia (CMML) is a clonal hematopoietic stem cell disorder that is classified as a myelodysplastic/myeloproliferative neoplasm by the 2008 World Health Organization classification of hematopoietic tumors. It is characterized by absolute monocytosis (&gt;1 × 10 9 /L) in the peripheral blood that persists for at least 3 months. Diagnosis The diagnosis of CMML rests on a combination of morphologic, histopathologic and chromosomal abnormalities in the bone marrow. It is important to exclude other myeloproliferative neoplasms and infectious/autoimmune conditions that can cause monocytosis. Risk stratification Several CMML‐specific prognostic models incorporating novel mutations have been recently reported. The Mayo prognostic model classified CMML patients into three risk groups based on: increased absolute monocyte count, presence of circulating blasts, hemoglobin &lt;10 gm/dL and platelets &lt;100 × 10 9 /L. The median survival was 32 months, 18.5 months and 10 months in the low, intermediate, and high‐risk groups, respectively. The Groupe Francophone des (GFM) score segregated CMML patients into three risk groups based on: age &gt;65 years, WBC &gt;15 × 10 9 /L, anemia, platelets &lt;100 × 10 9 /L, and ASXL1 mutation status. After a median follow‐up of 2.5 years, survival ranged from not reached in the low‐risk group to 14.4 months in the high‐risk group. Risk‐adapted therapy The Food and Drug Administration has approved azacitidine and decitabine for the treatment of patients with CMML. An allogeneic stem cell transplant can potentially offer a curative option to a subset of CMML patients. It is hoped that with the discovery of several novel mutations, targeted therapies will become available in the near future. Am. J. Heamtol. 88:968–974, 2013. © 2013 Wiley Periodicals, Inc.