RENAL GLOMERULAR AND VASCULAR LESIONS IN PREDIABETES AND IN DIABETES MELLITUS: A STUDY BASED ON RENAL BIOPSIES
Authors: Alberto Daysog, Harold L. Dobson, James C. Brennan
Journal: Annals of Internal Medicine (1961)

Article1 April 1961RENAL GLOMERULAR AND VASCULAR LESIONS IN PREDIABETES AND IN DIABETES MELLITUS: A STUDY BASED ON RENAL BIOPSIESALBERTO DAYSOG JR., M.D., HAROLD L. DOBSON, M.D., JAMES C. BRENNAN, M.D.ALBERTO DAYSOG JR., M.D.Search for more papers by this author, HAROLD L. DOBSON, M.D.Search for more papers by this author, JAMES C. BRENNAN, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-54-4-672 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptIt has long been suspected that the vascular disease seen in patients with diabetes mellitus might not be directly related to the control, severity, or duration of the carbohydrate defect.1-8 If this is true, it modifies and broadens the etiologic concept of diabetes.Of all forms of vascular disease, those found in the retina and in the kidney are the most specific for diabetes.9The literature on the renal glomerular involvement in diabetes is difficult to interpret. The presence or absence of the nodular (Kimmelstiel-Wilson) lesion does not depend on the severity10or on the clinical control7of the carbohydrate...Bibliography1. 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Med. 261: 442-443, 1959. CrossrefMedlineGoogle Scholar49. MillerReeves ECWJ: Severe juvenile diabetes of thirty-nine years' duration: a case report. Diabetes 9: 104-105, 1960. CrossrefMedlineGoogle Scholar50. West KM: Normal kidneys and retinae after 35 years of diabetes. Ann. Intern. Med. 47: 1256-1259, 1957. LinkGoogle Scholar51. Colwell AR: Observed course of diabetes mellitus and inferences concerning its origin and progress. Arch. Intern. Med. 70: 523-531, 1942. CrossrefGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: ALBERTO DAYSOGJR., M.D.; HAROLD L. DOBSON, M.D.; JAMES C. BRENNAN, M.D.*Received for publication October 26, 1960.From the Departments of Medicine and Pathology, Baylor University College of Medicine and Jefferson Davis Hospital, Houston, Texas.Presented at the meeting of the American Federation for Clinical Research, Atlantic City, New Jersey, May 1, 1960.Doctor Daysog is a Fellow in Diabetes and Metabolic Diseases, Baylor University College of Medicine and Jefferson Davis Hospital, Houston, Texas.Doctor Dobson is an Assistant Professor of Medicine, Baylor University College of Medicine, and Chief, Metabolic Section, Department of Internal Medicine, Baylor University College of Medicine and Jefferson Davis Hospital, Houston, Texas.Doctor Brennan is an Associate Professor of Pathology, Baylor University College of Medicine, and Associate Director of Laboratories, Jefferson Davis Hospital, Houston, Texas. Present address: Department of Pathology, Baltimore City Hospital, Baltimore, Maryland.†This study was carried out under Diabetic Teaching Grant No. 2A-5063, National Institute of Arthritis and Metabolic Disease. Support was also provided by Grant No. A-2563, National Institutes of Health; Eli Lilly & Company, the Texas State Department of Health; the Harris County Health Unit, and the Houston Heart Association Grant No. 603-9.Requests for reprints should be addressed to Harold L. Dobson, M.D., Department of Internal Medicine, Baylor University College of Medicine, Texas Medical Center, Houston, Texas . 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