tbuckley/cabot-search huggingface dataset:
DETECTION AND LOCALIZATION OF PROXIMAL RIGHT CORONARY ARTERY STENOSIS
Authors: Jock M. Gutmon, Alan Rozanski, Michael B. Brachman, Jamshid Maddahi, Ronald D. Levy, Nancy L. Pantaleo, H. J.C. Swan, Alan D. Waxman, Daniel S. Berman
Journal: Clinical Nuclear Medicine (1981)

Gutmon, Jock M.; Rozanski, Alan; Brachman, Michael B.; Maddahi, Jamshid; Levy, Ronald D.; Pantaleo, Nancy L.; Swan, H. J.C.; Waxman, Alan D.; Berman, Daniel S.Author Information
Abstract 676: Induction of apoptosis via control of cell adhesion by peroxisome proliferator activated receptor-gamma agonist in human uterine leiomyoma cells
Authors: Chi-Heum Cho, Sun-Wook Jung, So-Jin Shin, Sang-Hoon Kwon, Soon-Do Cha
Journal: Cancer Research (2010)

Abstract Objective : Peroxisome Proliferator-Activated Receptor (PPAR)-gamma ligands constitute important insulin sensitizers that have already been approved for the treatment of human metabolic disorders. It has been previously demonstrated that growth inhibition in human uterine leiomyoma cells mediated by caspase-dependent pathway and death receptor. The present study was designed to further understand the mechanism after uterine leiomyoma and normal myometrial cells were exposed to PPAR gamma agonist, Ciglitizone. Methods : In order to confirm the unknown cellular and biochemical responses to ciglitizone treatment with three uterine leiomyoma and normal myometrial cells, DNA chip analysis were performed. Highly up-regulated genes were confirmed to ascertain effect of PPAR gamma agonist by RT-PCR and Western-blot analysis. To analyze mechanism of invasion and metastasis -associating gene regulation by PPAR-γ ligands, wound healing assay and soft agar assay were performed. Results : DNA chip analysis revealed genes are related with cell adhesion and metastasis genes including plasminogen activating urokinase (PLAU), claudin 1, matrix metallopeptidase 1,2, and 9. Highly down-regulated genes had defense system against cell metastasis in common and was related with adhesion. Treatment with ciglitizone made decrease expression level of above cell adhesion related genes in dose dependent manner by RT-PCR and Western-blot analysis. Furthermore, treatment with ciglitizone in uterine leiomyoma cells decrease the invasion ability of leiomyoma cells and the formation of anchorage-independent colonies in soft agar. Conclusions : These results suggest that PPAR-gamma could be considered as a therapeutic target for diverse disease states in which excessive angiogenesis is implicated, including cancer and uterine leiomyoma. This phenomenon has not been previously reported for PPAR-gamma agonist in uterine leiomyoma. Defining the role of PPARγ in uterine leiomyoma cells will be paramount for a rational design of combinatorial therapy schemes that takes advantage of the potent and well-tolerated PPARγ agonists. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 101st Annual Meeting of the American Association for Cancer Research; 2010 Apr 17-21; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2010;70(8 Suppl):Abstract nr 676.
A third of UK households have at least one adult in pain
Authors: I. Vlad
Journal: BMJ (2003)

A third of households in the United Kingdom have at least one adult who is in pain, a conference in London was told last week. In a quarter of these households, two adults were in that position.

Professor David Peters, professor of integrated health at the University of Westminster, said pain was an important cause of absenteeism from work and that the cost …
Effectiveness of monovalent rotavirus vaccine in Bolivia: case-control study
Authors: M. M. Patel, M. Patzi, D. Pastor, A. Nina, Y. Roca, L. Alvarez, V. Iniguez, R. Rivera, K. I. Tam, O. Quaye, M. Bowen, U. Parashar, L. H. De Oliveira
Journal: BMJ (2013)

<b>Objective</b> To evaluate the effectiveness of two doses of a monovalent rotavirus vaccine (RV1) against hospital admission for rotavirus in Bolivia. <b>Design</b> Case-control study. <b>Setting</b> Six hospitals in Bolivia, between March 2010 and June 2011. <b>Participants</b> 400 hospital admissions for rotavirus, 1200 non-diarrhea hospital controls, and 718 rotavirus negative hospital controls. <b>Main outcome measures</b> Odds of antecedent vaccination between case patients and controls; effectiveness of vaccination ((1–adjusted odds ratio)×100), adjusted for age and other confounders; and stratified effectiveness by dose, disease severity, age group, and serotype. <b>Results</b> In comparison with non-diarrhea controls, case patients were more likely to be male and attend day care but less likely to have chronic underlying illness, higher level maternal education, and telephones and computers in their home. Rotavirus negative controls were somewhat more similar to case patients but also were more likely to be male and attend day care and less likely to have higher level maternal education and computers in their homes. The adjusted effectiveness of RV1 against hospital admission for rotavirus was 69% (95% confidence interval 54% to 79%) with rotavirus negative controls and 77% (65% to 84%) with non-diarrhea controls. The effectiveness of one dose of RV1 was 36% and 56%, respectively. With both control groups, protection was sustained through two years of life, with similar efficacy against hospital admission among children under 1 year (64% and 77%) and over 1 year of age (72% and 76%). RV1 provided significant protection against diverse serotypes, partially and fully heterotypic to the G1P[8] vaccine. Effectiveness using the two control groups was 80% and 85% against G9P[8], 74% and 93%% against G3P[8], 59% and 69% against G2P[4], and 80% and 87% against G9P[6] strains. <b>Conclusion</b> The monovalent rotavirus vaccine conferred high protection against hospital admission for diarrhea due to rotavirus in Bolivian children. Protection was sustained through two years of life against diverse serotypes different from the vaccine strain.
Metabolic Changes after Aorto-iliac Occlusion
Authors: D. K. Brooks, S. A. Feldman
Journal: BMJ (1965)

MEDIBALJOURNAimann's3 figures are correct, which give an expectancy rate for schizophrenia in the normal population as 0.85%, then the chances are that many of these patients who crowd the hospital departments and general prac- titioners' surgeries are ambulatory schizo- phrenics and help continue " the health service handicap."With better research and diagnostic facilities we might not have to say " hypochondriasis has a poor prognosis."-I am, etc.,
Role of Telomeres and Telomerase in the Pathogenesis of Human Cancer
Authors: William C. Hahn
Journal: Journal of Clinical Oncology (2003)

Specialized nucleoprotein structures, termed telomeres, cap the ends of human chromosomes. These terminal structures, composed of repetitive arrays of guanine-rich hexameric DNA together with specific telomere-binding proteins, play essential roles in protecting the chromosome from damage and degradation. In addition, several lines of evidence implicate telomere maintenance as an important regulator of cell life span. Activation of telomerase, a dedicated reverse transcriptase that synthesizes telomeric sequences, is strongly associated with cancer, and recent observations confirm that telomeres and telomerase perform important roles in both suppressing and facilitating malignant transformation. These dual functions of telomere biology are evident in the clinical manifestations of the multisystem syndrome, dyskeratosis congenita, forms of which display defects in telomerase function. Recent advances in our understanding of telomere biology indicate that the manipulation of telomeres and telomerase will lead to clinically significant applications in the diagnosis, prevention, and treatment of neoplastic disease.
Effectiveness of AS03 adjuvanted pandemic H1N1 vaccine: case-control evaluation based on sentinel surveillance system in Canada, autumn 2009
Authors: D. M. Skowronski, N. Z. Janjua, G. De Serres, T. S. Hottes, J. A. Dickinson, N. Crowcroft, T. L. Kwindt, P. Tang, H. Charest, K. Fonseca, J. B. Gubbay, N. Bastien, Y. Li, M. Petric
Journal: BMJ (2011)

<b>Objective</b> To assess the effectiveness of the pandemic influenza A/H1N1 vaccine used in Canada during autumn 2009. <b>Design</b> Test negative incident case-control study based on sentinel physician surveillance system. <b>Setting</b> Community based clinics contributing to sentinel networks in British Columbia, Alberta, Ontario, and Quebec, Canada. <b>Participants</b> 552 patients who presented to a sentinel site within seven days of onset of influenza-like illness during the primary analysis period between 8 November and 5 December 2009; participants were mostly (&gt;80%) children and adults under 50 years old. <b>Interventions</b> Monovalent AS03 adjuvanted pandemic influenza A/H1N1 vaccine as the predominant formulation (&gt;95%) distributed in Canada. <b>Main outcome measures</b> Vaccine effectiveness calculated as 1−(odds ratio for influenza in vaccinated (received pandemic H1N1 vaccine at least two weeks before onset of influenza-like illness) versus unvaccinated participants), with adjustment for age, comorbidity, province, timeliness of specimen collection, and week of illness onset. Sensitivity analyses explored the influence of varying analysis periods between 1 November and 31 December, receipt of trivalent seasonal influenza vaccine, and restriction to participants without comorbidity. <b>Results</b> During the primary analysis period, pandemic H1N1 was detected by reverse transcription polymerase chain reaction in 209/552 (38%) participants; rates were highest in children and young adults (40%) and lowest in people aged 65 or over (9%). Among the 209 cases, 35 (17%) reported comorbidity compared with 80/343 (23%) controls. Two (1%) cases had received pandemic H1N1 vaccine at least two weeks before the onset of illness, compared with 58/343 (17%) controls, all single dose. Adjusted vaccine effectiveness overall was 93% (95% confidence interval 69% to 98%). High estimates of vaccine protection—generally at least 90%—were maintained across most sensitivity analyses. <b>Conclusions</b> Although limited by a small number of vaccine failures, this study suggests that the monovalent AS03 adjuvanted vaccine used in Canada during autumn 2009 was highly effective in preventing medically attended, laboratory confirmed pandemic H1N1 illness, with reference in particular to a single dose in children and young adults.
Abstract 3953: The omental microenvironment promotes ovarian cancer metastasis and enhances CD-133 mediated self-assembly of ovarian cancer spheroids.
Authors: Molly A. Brewer, Guigin Sun, Matthew Anderson, Fanliang Meng, Mei Zhong
Journal: Cancer Research (2013)

Abstract Objective: Recent evidence suggests that the human omentum functions as a niche that promotes ovarian cancer metastasis. We investigated the role of the omentum in sequestration and enhancement of ovarian cancer stem cells. Materials and Methods: To further explore this unique phenomenon, we examined the ability of cells isolated from ovarian cancer implants at distinct anatomic sites to create multicellular aggregates known as spheroids. In ovarian and other cancers, spheroids promote a pluripotent phenotype and play a critical role in metastasis. Results: We found that ovarian cancer cells recovered from omentum express higher levels of the pluripotency-associated antigen CD133 and create larger numbers of more rapidly growing spheroids than cells recovered from the tubo-ovarian complex. Although CD133+ or CD44+ ovarian cancer cells are equally capable of creating large spheroids, spheroids self-assembled from CD133+ ovarian cancer cells are significantly more tumorigenic in vivo than CD44+, CD133−CD44− or unsorted cells. We also found that spheroids self-assembled from CD133+ ovarian cancer cells migrate to both the ovary and omentum of SCID mice and that CD133+ ovarian cancer cells induce intraperitoneal xenografts when inoculated subcutaneously. In contrast, our data indicate that spheroids self-assembled from CD44+ cells preferentially induce tumor adjacent to their inoculation site. Targeting CD133 expression inhibits the in vivo tumorigencity of spheroids assembled from A2780 ovarian cancer cells. Conclusions: In addition to delineating novel pathways by which the omental microenvironment promotes ovarian cancer metastasis, these findings establish a new paradigm for understanding how ovarian cancer stem cells can be potentially maintained or regenerated within the peritoneal cavity. Strategies to target the omental niche have enormous potential to improve ovarian cancer outcomes. Citation Format: Molly A. Brewer, Guigin Sun, Matthew Anderson, Fanliang Meng, Mei Zhong. The omental microenvironment promotes ovarian cancer metastasis and enhances CD-133 mediated self-assembly of ovarian cancer spheroids. [abstract]. In: Proceedings of the 104th Annual Meeting of the American Association for Cancer Research; 2013 Apr 6-10; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2013;73(8 Suppl):Abstract nr 3953. doi:10.1158/1538-7445.AM2013-3953
TCT-224 TIMI ≥ 2 in Right Ventricular Branches after Primary PCI, protects Right Ventricle against Infarction in the evaluation of Late Enhancement Cardiac Magnetic Resonance Imaging.
Authors: Marek T. Tomala, Tomasz Miszalski-Jamka, Bartlomiej Nawrotek, Wociech Zajdel, Krzysztof F. Zmudka
Journal: Journal of the American College of Cardiology (2013)
SPRUE AND PERNICIOUS ANAEMIA
Authors: B. Bramwell
Journal: BMJ (1924)

Nervous System.Cranial Nerves-The leftpupil was smaller than the right, but both reacted to light and accommodation.Lateral nystagmus was present, which was more marked on looking to tlhe right.The patient did not complain of diplopia and the ocular muscles acted perfectly.There was no weakness of any facial-muscles, nor did the tongue when protruded deviate to either side.All the special senses, including taste, were normal.The left side of the palate wras paralysed, but Dr. D. Lindley Sewell found no affection of any
A prospective, randomized placebo-controlled multicenter trial evaluating fenoldopam mesylate for the prevention of contrast induced nephropathy: The CONTRAST trial
Authors: Gregg W. Stone, Peter McCullough, James Tumlin, Hooman Madyoon, Patrick Murray, Andrew Wang, A. Alan Chu, Gary Schaer, Melissa Stevens, Robert L. Wilensky, William W. O'Neill, Norman Lepor
Journal: Journal of the American College of Cardiology (2003)
Effect of nibbling versus gorging on cardiovascular risk factors: Serum uric acid and blood lipids
Authors: David J.A. Jenkins, Aneal Khan, Alexandra L. Jenkins, Roger Illingworth, Anuradhe S. Pappu, Thomas M.S. Wolever, Vladimir Vuksan, Gloria Buckley, A.Venketeshwer Rao, Stephen C. Cunnane, Furio Brighenti, Meredith Hawkins, Mohamed Abdolell, Paul Corey, Robert Patten, Robert G. Josse
Journal: Metabolism (1995)
Low Fasting Plasma Glucose Level as a Predictor of Cardiovascular Disease and All-Cause Mortality
Authors: Ming Wei, Larry W. Gibbons, Tedd L. Mitchell, James B. Kampert, Michael P. Stern, Steven N. Blair
Journal: Circulation (2000)

Background —Although medical textbooks usually classify fasting plasma glucose &lt;70 or 80 mg/dL (&lt;3.89 or 4.44 mmol/L) as abnormal, the prognosis for patients with low fasting plasma glucose is unclear. Methods and Results —We conducted prospective cohort studies among 40 069 men and women to investigate the association between fasting plasma glucose levels and cardiovascular disease and all-cause mortality. We documented a U-shaped relation between fasting plasma glucose and mortality. In addition to diabetes and impaired fasting glucose levels, low fasting plasma glucose levels were also associated with high mortality. After multivariate adjustment for age, sex, study population, ethnicity, current smoking status, high blood pressure, total cholesterol, body mass index, triglycerides, history of cardiovascular disease and cancer, and a family history of cardiovascular disease, patients with fasting plasma glucose &lt;70 mg/dL (&lt;3.89 mmol/L) had a 3.3-fold increased risk of cardiovascular disease mortality, and patients with fasting plasma glucose 70 to 79 mg/dL (3.89 to 4.43 mmol/L) had a 2.4-fold increased risk compared with the risk in patients with fasting plasma glucose 80 to 109 mg/dL (4.44 to 6.05 mmol/L) (tests for trend P &lt;0.0001). Participants with low fasting plasma glucose levels also had increased risk of all-cause mortality (test for trend P &lt;0.0001). Conclusions —Participants with low fasting plasma glucose levels had a high risk of cardiovascular disease and all-cause mortality.
Research suggests thrombolysis is effective for acute ischaemic stroke
Authors: Barbara Kermode-Scott
Journal: BMJ (2005)

New Canadian research suggests that thrombolysis is a safe and effective treatment for acute ischaemic stroke ( CMAJ 2005;172: 1307-12). Researchers assessed the safety and effectiveness of tissue plasminogen activator (alteplase, t-PA) as a routine treatment for acute stroke at 60 centres across Canada. In Canada, alteplase treatment for stroke was conditionally licensed in 1999. As a condition of approval, a prospective registry to monitor safety was mandated by the federal government. The Canadian alteplase for stroke effectiveness study (CASES) was launched to collect data on outcomes for all patients treated with alteplase in Canada.
Severe high grade stenosing hyperkeratosis of the esophagus after ingestion of alkali: successful treatment by argon plasma coagulation
Authors: F. Boxberger, J. Maiss, K. Amann, R. Janka, A. Wein, G. Maennlein, E. Hahn, M. Raithel
Journal: Endoscopy (2008)

The ingestion of acids or lyes may lead to reversible or irreversible lesions of the upper gastrointestinal tract [1]. In cases of alkali ingestion, esophageal strictures concomitant to dysphagia constitute a major problem of the long-term course. Regular follow-up by endoscopy is recommended owing to the significantly increased risk of developing esophageal carcinoma [2].
The significance of mouse liver tumor formation for carcinogenic risk assessment: results and conclusions from a survey of ten years of testing by the agrochemical industry.
Authors: N G Carmichael, H Enzmann, I Pate, F Waechter
Journal: Environmental Health Perspectives (1997)

A survey was performed on the results of 138 carcinogenicity studies conducted in various mouse strains by the agrochemical industry over the period 1983-1993. Data for liver tumor incidence, liver weight, and histopathology were collected along with data on genotoxicity. Studies were judged positive or negative for liver tumor formation on the basis of apparent dose response, malignancy, and difference from historical control values using a weight of evidence approach. Thirty-seven studies were judged to be positive for liver tumorigenicity in one or both sexes. There was no evidence showing an influence of the mouse strain and the duration of the study on the proportion of positive studies. Although 8 of the chemicals tested in the 138 studies were positive in the Ames test, only one of these was judged positive for carcinogenicity. Only 6 of the 37 positive chemicals had any other reported positive genotoxicity findings. A clear relationship between hepatomegaly at 1 year after exposure and a positive tumorigenic outcome at 18 months or 2 years after exposure was demonstrated. Whereas the average relative liver weight of top dose animals was 110% of control in negative studies, it was 150% in positive studies. Likewise, very few negative studies demonstrated significant pathological findings after 1 year, whereas the majority of positive studies had significant liver pathology. The implications of these findings for extrapolation to humans are discussed.
Epidemiology as a Liberal Art
Authors: David W. Fraser
Journal: New England Journal of Medicine (1987)

Epidemiology has features that resemble those of the traditional liberal arts. This makes it fit both for inclusion in an undergraduate curriculum and as an example in medical school of the continuing value of a liberal education. As a "low-technology" science, epidemiology is readily accessible to nonspecialists. Because it is useful for taking a first look at a new problem, it is applicable to a broad range of interesting phenomena. Furthermore, it emphasizes method rather than arcane knowledge and illustrates the approaches to problems and the kinds of thinking that a liberal education should cultivate: the scientific method, analogic thinking, deductive reasoning, problem solving within constraints, and concern for aesthetic values.
Lyme Disease and Uveitis
Authors: José Antonio Oteo
Journal: Annals of Internal Medicine (1990)

Letters and Corrections1 June 1990Lyme Disease and UveitisJosé Antonio Oteo, MD, Victor Martinez de Artola, MD, Elias Maravi, MD, José Maria Eiros, MDJosé Antonio Oteo, MDSearch for more papers by this author, Victor Martinez de Artola, MDSearch for more papers by this author, Elias Maravi, MDSearch for more papers by this author, José Maria Eiros, MDSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-112-11-883 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the Editor: Ocular manifestations other than conjunctivitis have rarely been reported in patients with Lyme disease (1). Occasional case reports have documented the association of Lyme disease and several syndromes affecting eyes, including blurred temporal vision due to high intracraneal pressure, diplopia caused by oculomotor nerve palsies, ischemic optic neuropathy, keratitis, pseudotumor cerebri, choroiditis and exudative retinal detachments, and orbital myositis. To our knowledge, only a few cases of anterior uveitis have been described (2, 3). We have recently observed the development of an anterior uveitis in a patient diagnosed as having Lyme disease.A 43-year-old man presented with...References1. Schechter S. Lyme disease associated with optic neuropathy. Am J Med. 1986;81:143-5. CrossrefMedlineGoogle Scholar2. SteereDurayKauffmannWormser APDG. Unilateral blindness caused by infection with the Lyme disease spirochete, Borrelia burgdorferi. Ann Intern Med. 1985;103:382-4. LinkGoogle Scholar3. WinwardSmithCulbertsonParis-Hamelin KJWA. Ocular Lyme borreliosis. Am J Ophthalmol. 1989;108:651-7. CrossrefMedlineGoogle Scholar4. MagnarelliAndersonJohnson LJR. Cross reactivity in serological test for Lyme disease and other spirochetal infections. J Infect Dis. 1987;156:183-7. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: José Antonio Oteo, MD; Victor Martinez de Artola, MD; Elias Maravi, MD; José Maria Eiros, MDAffiliations: Hospital Virgen del Camino 31008 Pamplona Spain PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byNeuroborreliosis: serie de 7 casos en un hospitalNeuroborreliosis: A single-hospital series of 7 casesEritema migratorio (borreliosis de Lyme). Características clinicoepidemiológicas de 50 pacientesLyme disease: case report and review 1 June 1990Volume 112, Issue 11Page: 883-883KeywordsConjunctivitisLyme diseaseMyositisNervesOptic neuropathyParalysisRetinal detachmentUveitisVision ePublished: 1 December 2008 Issue Published: 1 June 1990 PDF downloadLoading ...