THE EFFECTS OF BREATHING 99.6% OXYGEN ON PULMONARY VASCULAR RESISTANCE AND CARDIAC OUTPUT IN PATIENTS WITH PULMONARY EMPHYSEMA AND CHRONIC HYPOXIA
Authors: R H WILSON, W HOSETH, M E DEMPSEY
Journal: Annals of Internal Medicine (1955)

Article1 March 1955THE EFFECTS OF BREATHING 99.6% OXYGEN ON PULMONARY VASCULAR RESISTANCE AND CARDIAC OUTPUT IN PATIENTS WITH PULMONARY EMPHYSEMA AND CHRONIC HYPOXIARUSSELL H. WILSON, M.D., Ph.D., WAYNE HOSETH, M.D., MARY E. DEMPSEY, M.S.RUSSELL H. WILSON, M.D., Ph.D., WAYNE HOSETH, M.D., MARY E. DEMPSEY, M.S.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-42-3-629 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptIt is well established, experimentally, that acute hypoxia causes a significant elevation of the pulmonary arterial blood pressure. The magnitude of the rôle of chronic hypoxia in increasing the pulmonary vascular resistance leading to increased pressure in the lesser circulation has not been clearly defined. Efforts have been made to separate the effects of changes in the magnitude of cardiac output and pulmonary vascular resistance on the pulmonary arterial pressure, but the relationship of each phenomenon to acute and chronic pulmonary hypertension has not been clearly established.Von Euler and Liljestrand1found that in cats the pulmonary arterial pressure increased...Bibliography1. Von EulerLiljestrand USG: Observations on the pulmonary arterial blood pressure in the cat, Acta physiol. Scandinav. 12: 301, 1946. CrossrefGoogle Scholar2. MotleyCournandWerkoHimmelsteinDresdale HLALAD: The influence of short periods of induced acute anoxia upon pulmonary artery pressure in man, Am. J. Physiol. 150: 315, 1947. CrossrefMedlineGoogle Scholar3. WestcottFowlerScottHauensteinMcGuire RNNORCVDJ: Anoxia and human pulmonary vascular resistance, J. Clin. Investigation 30: 957, 1951. CrossrefMedlineGoogle Scholar4. Liljestrand G: Regulation of the pulmonary arterial blood pressure, Arch. Int. 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