TREATMENT OF HYPERTENSION WITH ORAL PROTOVERATRINE
Authors: S W HOOBLER, R W CORLEY, T G KABZA, H F LOYKE
Journal: Annals of Internal Medicine (1952)

Article1 September 1952TREATMENT OF HYPERTENSION WITH ORAL PROTOVERATRINES. W. HOOBLER, M.D., F.A.C.P., R. W. CORLEY, M.D., T. G. KABZA, M.D., H. F. LOYKE, M.D.S. W. HOOBLER, M.D., F.A.C.P., R. W. CORLEY, M.D., T. G. KABZA, M.D., H. F. LOYKE, M.D.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-37-3-465 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptProtoveratrine, a purified derivative ofVeratrum album,1, 2is superior to the alkaloids fromVeratrum viridewhich have been used previously in the treatment of hypertension in that, in a carefully adjusted dosage schedule, the blood pressure can be reduced for six to eight hours daily without producing nausea, vomiting or tolerance to the medication. Such temporary remissions in blood pressure are of a magnitude and duration sufficient to afford real relief to the heart and arteries of the hypertensive patient. We have reported elsewhere3, 4that parenteral administration of protoveratrine is accompanied by a decline in resistance to blood...Bibliography1. KrayerMoeMendez OGKR: Protoveratrine: its comparative toxicity and its circulatory action, J. Pharmacol. and Exper. Therap. 82: 167, 1944. Google Scholar2. MeilmanKrayer EO: The action of protoveratrine and Veratridine in hypertension, Circulation 1: 204, 1950. CrossrefMedlineGoogle Scholar3. HooblerCorley SWRW: The hypotensive action of protoveratrine, U. of Mich. M. Bull. 16: 362, 1950. Google Scholar4. HooblerCorleyKabza SWRWTG: Effects of protoveratrine on the circulation in hypertension (abstract), Am. J. Med. 12: 110, 1952. CrossrefGoogle Scholar5. WilkinsStantonFreis RWJRED: Essential hypertension. Therapeutic trial of Veriloid, a new extract of Veratrum viride , Proc. Soc. Exper. Biol. and Med. 72: 725, 1949. CrossrefGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Ann Arbor, Michigan*Presented at the Thirty-third Annual Session of the American College of Physicians, Cleveland, Ohio, April 22, 1952.From the Department of Medicine, University of Michigan Medical School, Ann Arbor, Michigan. Supported by grants from the National Heart Institute, U. S. Public Health Service and Eli Lilly & Co. We are indebted to Dr. Otto Krayer, Professor of Pharmacology, Harvard Medical School, and to Dr. Kenneth Kohlstaedt, Eli Lilly & Co., for the supply of Protoveratrine which they kindly placed at our disposal. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byVeratridine☆VeratridineVeratrum Alkaloids with Antihypertensive ActivityThe Veratrum AlkaloidsVERATRUM ALKALOIDS AND OTHER DRUGS STIMULATING CHEMOREFLEXESTreatment of Hypertension with 'Miopressin'Hypotensive Veratrum Ester AlkaloidsComparative Studies of Protoveratrine A and Protoveratrine B Intravenously in Hypertensive ManBehandlung der benignen und malignen HypertonieHypertonieHypertonieINTRAVENOUS PROTOVERATRINE IN THE PREVENTION AND MANAGEMENT OF ECLAMPSIAOral protoveratrine in the treatment of hypertension∗The management of moderately severe hypertension with cryptenamine and rauwolfiaA Comparison between Protoveratrine A and Protoveratrine B Orally in Arterial HypertensionCardiac arrhythmias associated with protoveratrineThe Management of Hypertensive Cardiovascular DiseaseTREATMENT OF PRIMARY HYPERTENSION IN THE OLDER AGE GROUPProtoveratrin in der Behandlung der HypertonienProlonged depression of atrioventricular conduction caused by large dosages of protoveratrineTreatment of hypertensionCardiac EmergenciesTREATMENT OF HYPERTENSION IN THE ELDERLY PATIENTTHE TREATMENT OF HYPERTENSION WITH DRUGS*MILTON MENDLOWITZ, M.D., F.A.C.P.The use of protoveratrine in the treatment of hypertensive vascular diseaseThe Medical Management of Arterial HypertensionTHE MANAGEMENT OF MALIGNANT HYPERTENSION*MAURICE SOKOLOW, M.D., F.A.C.P., MARY F. SCHOTTSTAEDT, M.D. 1 September 1952Volume 37, Issue 3Page: 465-481KeywordsAlkaloidsArteriesBloodBlood pressureHeartHypertensionMedical servicesNauseaPharmacologyVomiting ePublished: 1 December 2008 Issue Published: 1 September 1952 PDF downloadLoading ...