SERUM CONCENTRATIONS OF VITAMIN B_12 IN ACUTE LEUKEMIA
Authors: M F BEARD, W R PITNEY, E H SANNEMAN, M J SAKOL, H H MOORHEAD
Journal: Annals of Internal Medicine (1954)

Article1 August 1954SERUM CONCENTRATIONS OF VITAMIN B12 IN ACUTE LEUKEMIAMARION F. BEARD, M.D., F.A.C.P., W. R. PITNEY, M.D., M.R.A.C.P., EVERETT H. SANNEMAN, M.D., MARVIN J. SAKOL, M.D., HARRY H. MOORHEAD, M.D.MARION F. BEARD, M.D., F.A.C.P., W. R. PITNEY, M.D., M.R.A.C.P., EVERETT H. SANNEMAN, M.D., MARVIN J. SAKOL, M.D., HARRY H. MOORHEAD, M.D.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-41-2-323 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptIn a previous paper,1 serum concentrations of vitamin B12 in patients suffering from chronic leukemia were reported. It was shown that, in chronic lymphocytic leukemia, serum contains a normal concentration of the vitamin, whereas in chronic myelocytic leukemia the concentration is markedly increased.A preliminary report of serum vitamin B12concentrations in seven cases of acute leukemia suggested that the variable concentrations found might be associated with morphologic differences in cell types such as occur in chronic leukemia. In this paper a morphologic diagnosis has been attempted in 20 cases of acute leukemia, and comparison made with the serum vitamin...Bibliography1. BeardPitneySanneman MFWREH: Serum concentrations of vitamin B12 in patients suffering from leukemia, Blood, in press. Google Scholar2. Ross GI: Vitamin B12 assay in body fluids using Euglena gracilis , J. Clin. Path. 5: 250, 1952. CrossrefMedlineGoogle Scholar3. PitneyBeardVanLoon WRMFEJ: Observations on the bound form of vitamin B12 in human serum, J. Biol. Chem., in press. Google Scholar4. Welsh I: Failure of massive doses of vitamin B12 in acute leukemia, Brit. M. J. 2: 1133, 1952. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Louisville, Kentucky*Received for publication March 10, 1954.This study was made possible by a grant from the National Institutes of Health, Bethesda, Maryland, under grant number A-112. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byThe Functional Assessment of Nutritional Status: Principles, Practice and PotentialSerum Protein Binding of Vitamin B1212Co60 Vitamin B12 Binding Capacity of Serum in Persons with Hematologic Disorders, Various Medical Diseases and NeoplasmsMicrobiological Methods of Assay in Clinical Medicine with Particular Reference to the Investigation of Deficiency of Vitamin B 12 and Folic AcidHICH LEITOCYTOSIS (LEUKAEMOID REACTIONS?) IN DERMATITIS HERPETIFORMIS.Differential Serum Vitamin B 12 Concentrations in Mothers and InfantsEffect of 6-mercaptopurine (6-MP) on the serum level of vitamin B12 in leukemiaDer vitamin B12-stoffwechsel bei hamoblastosenVitamin B 12 Content of Normal and Leukaemic LeucocytesSerum Vitamin B 12 Concentrations in Leukaemia and in some other Haematological ConditionsThe Chemotherapeutic Action of Vitamin B12 1 August 1954Volume 41, Issue 2Page: 323-327KeywordsAttentionChronic lymphocytic leukemiaChronic myelocytic leukemia ePublished: 1 December 2008 Issue Published: 1 August 1954 PDF downloadLoading ...