tbuckley/cabot-search huggingface dataset:
Measurement of regional wall motion from biplane contrast ventriculograms: a comparison of the 30 degree right anterior oblique and 60 degree left anterior oblique projections in patients with acute myocardial infarction.
Authors: F H Sheehan, J Schofer, D G Mathey, M A Kellett, H Smith, E L Bolson, H T Dodge
Journal: Circulation (1986)

The value of performing biplane vs single plane analysis of regional wall motion from contrast ventriculograms was determined in 102 patients who received thrombolytic therapy and who underwent biplane ventriculography during acute myocardial infarction (n = 67), at follow-up more than 2 weeks later (n = 80), or both (n = 45). Hypokinesis in the infarct region and hyperkinesis in the noninfarct region were measured by the centerline method in the respective artery territories, which were defined from the data of 62 patients with single-vessel disease and were expressed in units of standard deviations from the mean of 32 normal subjects. Hypokinesis was more severe and extended over a longer segment of the left ventricular contour when measured in the right anterior oblique (RAO) projection in thrombosis of the left anterior descending coronary artery (LAD) but more severe and extensive in the left anterior oblique (LAO) projection in circumflex stenosis. Hyperkinesis opposite the LAD or the circumflex was greater in the LAO projection. In patients with thrombosis of the right coronary artery, wall motion abnormalities were similar in the two projections. Thus the evaluation of hypokinesis caused by acute coronary thrombosis and of the effect of therapeutic interventions in salvaging function can be adequately evaluated from single-plane 30 degree RAO ventriculograms, except in the small minority of patients with circumflex thrombosis.
Adjuvant Cisplatin and Vinorelbine for Completely Resected Non-small Cell Lung Cancer: Subgroup Analysis of the Lung Adjuvant Cisplatin Evaluation
Authors: Jean-Yves Douillard, Hélène Tribodet, Delphine Aubert, Frances A. Shepherd, Rafael Rosell, Keyue Ding, Anne-Sophie Veillard, Lesley Seymour, Thierry Le Chevalier, Stephen Spiro, Richard Stephens, Jean Pierre Pignon
Journal: Journal of Thoracic Oncology (2010)
Spontaneous Fatal Gas Gangrene Septicemia
Authors: Ernest E. Smucker
Journal: JAMA (1960)

Only three instances of spontaneous gas gangrene septicemia originating within the abdomen were found in a review of the literature.<sup>1</sup>The purpose of this contribution is to report an additional case and to show the problems in its differential diagnosis. The clostridia responsible for clinical gas gangrene may be present within the body and cause no clinical manifestations. Such organisms are regularly ingested and pass through the intestinal tract, producing no clinical evidence of the disease; or, the organism may be cultured in a wound and produce no clinical evidence of its presence; or, it may be found in a wound having an anaerobic environment partly created by necrotic muscle and produce clinical evidence of gas gangrene, which remains localized for a time but finally spreads along muscle planes, causing an overwhelming toxemia, shock, and eventually death. Blood cultures may reveal clostridia without the clinical manifestations or evidence of
MECHANICAL FACTORS IN CONSTIPATION
Authors: DUDLEY SMITH
Journal: JAMA (1930)

Constipation is a symptom of a large number of diseases. It is probably the most frequent symptom the physician is called on to treat. It is a glorified symptom raised to the dignity of a true disease entity by the public, and in this misconception the public is not alone in error. Judging by the methods of examination and treatment used by many physicians, one must conclude that they too are imbued with the same idea. True, it is an important symptom, and its palliation is well worth while and may result in great good to the patient; but we should not as scientific men and women be satisfied to palliate if by careful study and examination we can discover and cure the underlying condition on which the symptom rests. Much study and experiment have been devoted to the subject from the physiologic standpoint by many men, and physicians are
THE PATHOGENESIS OF UREMIA AND ECLAMPSIA.
Authors: ROBERT N. WILLSON
Journal: JAMA (1904)

Under a rather hackneyed title, it is my purpose to discuss very briefly a subject that will always be of interest until the mystery which surrounds the direct causal influences of uremia and eclampsia is entirely and finally dispelled. None of the theories offered up to the present time has been thoroughly satisfactory in explaining either the uremic state, which seems to be associated always with renal insufficiency, or that of eclampsia, which may or may not be preceded by signs of renal disability, but presents an almost identical clinical picture. I think it fair to state that I have never seen a case of eclampsia in which the urine, drawn by catheter during the coma or the convulsive period, failed to give abundant evidence of a serious renal involvement. I have seen this statement borne out in cases in which there was neither a trace of albumin nor a single form of renal sediment distinguishable by the microscope prior to the onset of the convulsive seizure.
Abstract S2-05: 10-yr follow-up results of occult detected sentinel node disease: NSABP B-32, a randomized phase III clinical trial to compare sentinel node resection (SNR) to conventional axillary dissection (AD) in clinically node-negative breast cancer patients
Authors: TB Julian, SJ Anderson, DN Krag, DL Weaver, JP Costantino, T Ashikaga, SP Harlow, EP Mamounas, N Wolmark
Journal: Cancer Research (2013)

Abstract Background: NSABP B-32, the largest surgical prospective randomized phase III trial was designed to compare overall survival (OS), disease-free survival (DFS), and morbidity between SNR alone versus SNR + AD in SN negative (-) pts. This trial also had the opportunity to investigate the clinical significance of occult metastatic disease in sentinel nodes. We present the 10-yr data of the occult metastatic disease secondary endpoint outcomes analysis. Methods: 5,611 women with operable, clinically N0, invasive breast cancer were randomized to SNR + AD (G1) or to SNR alone with AD only if SNs were positive (G2). Pathologically negative sentinel nodes underwent a blinded detailed central pathology review using IHC stains for detection of occult metastatic disease. These findings were then analyzed for their effects on outcomes. Results: At 10 yrs, there continues to be no significant difference in OS (HR: 1.09, p = 0.35), DFS (HR: 1.02, p = 0.72), or local/regional recurrence (HR: 0.96, p = 0.77) between G1 and G2. Local-regional recurrences were 4.3% (G1) and 4.0% (G2) with axillary recurrences at 0.2% and 0.5% respectively. Median time on study was 131.1 months. Of the 5,611 pts., 3,989 were SN- and 3,986 (99.9%) of these SN- pts had follow-up information (G1: 1,975, G2: 2,011). 3,884 of these patients underwent blinded IHC analyses (1,924 [G1] and 1,960 [G2]). 616 patients were found to have sentinel node occult metastatic disease: 316 (16.4%) from G1 and 300 (15.3%) from G2. There was a nearly significant difference in OS between the occult and non-occult metastases groups (HR: 1.26, p = 0.06), and a significant difference in DFS between the two groups (HR: 1.24, p = 0.01) was found. Local-regional recurrence was not significantly different (HR: 0.8, p = 0.52). Occult local regional recurrences were 32 of the study total 165 (19.3%) with only 5 axillary recurrences in G2 related to SN occult detected disease. No statistical differences were found between the occult groups with and without axillary dissection for OS (HR: 0.98, p = 0.91) or DFS (HR: 0.82, p = 0.2). Conclusions: Although occult metastatic disease was detected in H&amp;E negative sentinel nodes, its presence had no significant impact on OS, DFS, or local-regional recurrences in the large group of 5,611 patients. Specifically, in Group 2 with SN only, the 15.3% of pts with IHC positive nodes caused no significant impact on axillary failures. IHC use is not routinely recommended. Support: PHS grants: NSABP: U10CA-12027, U10CA-37377, U10CA-69651, U10CA-69974; VT Ca Cntr: P30 CA22435; DNK: 5RO1CA074137 NCI Dpt HHS. Citation Information: Cancer Res 2013;73(24 Suppl): Abstract nr S2-05.
Erroneous Left Ventricular Cavity Size Measurements on Myocardial Perfusion SPECT Resulting From Transient Arrhythmias
Authors: Iain D. C. Kirkpatrick, William D. Leslie
Journal: Clinical Nuclear Medicine (2005)

Transient ischemic dilatation (TID) of the left ventricle during stress on myocardial perfusion imaging is a sign of severe coronary artery disease. Factors other than ischemia can transiently influence left ventricular size, however, and TID ratios can be misleading if these factors are not properly identified. We describe 4 cases of stress-rest Tc-99m sestamibi SPECT myocardial perfusion imaging in which both abnormally high and low TID ratios were seen as a result of the presence of transient supraventricular tachyarrhythmias that reduced cardiac filling time and corresponding left ventricular volumes.
988-5 Aspirin-induced Reperfusion in Acute Myocardial Infarction
Authors: Arieh Freifeld, Babeth Rabinowitz, Elieser Kaplinsky, Michal Benderly, Michael Scheinowitz, Oren Agranat, Dov Freimark, Hanoch Hod
Journal: Journal of the American College of Cardiology (1995)
&lt;EMPH&gt;JAMA&lt;/EMPH&gt;, Abortion, and Editorial Responsibility
Authors: George D. Lundberg
Journal: JAMA (1998)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Medical Malpractice Implications of Alternative Medicine
Authors: David M. Studdert
Journal: JAMA (1998)

Although use of alternative therapies in the United States is widespread and growing, little is known about the malpractice experience of practitioners who deliver these therapies or about the legal principles that govern the relationship between conventional and alternative medicine. Using data from malpractice insurers, we analyzed the claims experience of chiropractors, massage therapists, and acupuncturists for 1990 through 1996. We found that claims against these practitioners occurred less frequently and typically involved injury that was less severe than claims against physicians during the same period. Physicians who may be concerned about their own exposure to liability for referral of patients for alternative treatments can draw some comfort from these findings. However, liability for referral is possible in certain situations and should be taken seriously. Therefore, we review relevant legal principles and case law to understand how malpractice law is likely to develop in this area. We conclude by suggesting some questions for physicians to ask themselves before referring their patients to alternative medicine practitioners.
Your theory of the evolution of morality depends upon your theory of morality
Authors: David Kirkby, Wolfram Hinzen, John Mikhail
Journal: Behavioral and Brain Sciences (2013)

Abstract Baumard et al. attribute to humans a sense of fairness. However, the properties of this sense are so underspecified that the evolutionary account offered is not well-motivated. We contrast this with the framework of Universal Moral Grammar, which has sought a descriptively adequate account of the structure of the moral domain as a precondition for understanding the evolution of morality.
Incorporating Environmental Health into Pediatric Medical and Nursing Education
Authors: Leyla Erk McCurdy, James Roberts, Bonnie Rogers, Rebecca Love, Ruth Etzel, Jerome Paulson, Nsedu Obot Witherspoon, Allen Dearry
Journal: Environmental Health Perspectives (2004)

Pediatric medical and nursing education currently lacks the environmental health content necessary to appropriately prepare pediatric health care professionals to prevent, recognize, manage, and treat environmental-exposure-related disease. Leading health institutions have recognized the need for improvements in health professionals' environmental health education. Parents are seeking answers about the impact of environmental toxicants on their children. Given the biologic, psychological, and social differences between children and adults, there is a need for environmental health education specific to children. The National Environmental Education and Training Foundation, in partnership with the Children's Environmental Health Network, created two working groups, one with expertise in medical education and one with expertise in nursing education. The working groups reviewed the transition from undergraduate student to professional to assess where in those processes pediatric environmental health could be emphasized. The medical education working group recommended increasing education about children's environmental health in the medical school curricula, in residency training, and in continuing medical education. The group also recommended the expansion of fellowship training in children's environmental health. Similarly, the nursing working group recommended increasing children's environmental health content at the undergraduate, graduate, and continuing nursing education levels. Working groups also identified the key medical and nursing organizations that would be important in leveraging these changes. A concerted effort to prioritize pediatric environmental health by governmental organizations and foundations is essential in providing the resources and expertise to set policy and provide the tools for teaching pediatric environmental health to health care providers.
Endoscopic treatment of a transversely impacted perforating fish bone in the esophagus with pneumomediastinum
Authors: M. Swan, M. Bourke, A. Hopper, A. Moss, S. Walker
Journal: Endoscopy (2010)

Impacted esophageal foreign bodies are a relatively common indication for urgent endoscopy [1]. We report a case, and demonstrate with video, the endoscopic removal of a perforating fish bone and the endoscopic closure of the perforation.
Double pylorus secondary to recurrent ulcer: serial endoscopy follow-up
Authors: T. Lee, S. Park
Journal: Endoscopy (2008)

A 67-year-old man with alcoholic liver disease underwent esophagogastroduodenoscopy (EGD) as follow-up to gastric ulcer. Eleven months earlier he had been hospitalized because of hematemesis and melena. The EGD noted a bleeding gastric ulcer at the lesser curve of the gastric antrum ([Fig. 1]). Subsequently, following endoscopic hemoclipping, he was treated with a proton pump inhibitor (PPI) for 1 month. Thereafter he remained well. However, he was lost to follow-up, and treated intermittent epigastric pain with self-prescribed antacids. Eight months later, he revisited our hospital due to persistent epigastric pain. EGD showed an ulcerative lesion in the same area as before ([Fig. 2]). Over the next 3 months he experienced intermittent episodes of epigastric soreness; however, generally he was much improved over his previous condition and intermittently took antacids. EGD performed 11 months after the first endoscopy, revealed an accessory pyloric canal on the lesser curve of the antrum, where the ulcer had been observed previously. The gastric antrum and bulb had become connected by two openings separated by a septum, which is an acquired complication of recurrent gastric ulcer ([Fig. 3 a]). The scope could enter the duodenal bulb through either the pyloric or the accessory canal ([Fig. 3 b]).
P226 Prevalence and treatment of pain in hospital in-patients with respiratory disease
Authors: K. Matthews, D. Brunnen, Y. Mahmood, E. H. Baker
Journal: Thorax (2010)

<h3>Introduction and objectives</h3> Pain is common, with 43% of medical inpatients experiencing moderate to severe pain [Dix <i>et al BJA</i> 2004;92(2):235–237]. Factors contributing to inadequate pain relief include concerns about analgesic side effects, drug interactions and impact of treatment on co-morbidities. In respiratory in-patients we audited prevalence and severity of pain, adequacy of pain relief and contraindications to escalation of analgesia. <h3>Methods</h3> Unselected adult inpatients (≥16 years) with respiratory disease managed on a respiratory specialist ward were included in the audit. Patients with lung cancer or chest drains were excluded. Diagnoses, investigation results and medications were collected from patient records and patients underwent pain assessment (Brief Pain Inventory). Analgesia was defined as inadequate if patients reported an average pain score or pain interference score (pain interfering with daily activities) &gt;3/10 during the previous 24 h. For patients with inadequate analgesia, cautions and contraindications to analgesics and non-steroidal anti-inflammatory drugs (NSAIDs) were determined to establish whether analgesia could be escalated. <h3>Results</h3> Of 101 patients interviewed, main respiratory diagnoses were: COPD (40%), pneumonia/LRTI (38%), asthma (13%) and other (10%). 52 patients reported any pain in the last 24 h, of which the sites of worst pain were chest (44%), back (25%), limb (19%) and other (12%). Of these patients, 85% (n=44) were assessed as having inadequate analgesia. Abstract P226 Table 1 groups those patients with inadequate analgesia by position on the WHO analgesic ladder and details the proportion of patients who have no contraindication to stepping up the ladder. Abstract P226 Table 1 also highlights the proportion of patients who may benefit from adjuvant NSAID therapy. Of those patients with inadequate analgesia, 82% (n=36) had no contraindication to escalation of analgesia and 32% (n=14) had no contraindication to treatment with NSAIDs. <h3>Conclusions</h3> Pain is common in hospital in-patients with respiratory disease. 44% of respiratory in-patients did not receive adequate analgesia. 82% of these had no contraindication to stepping up the pain ladder and 32% could have had an NSAID added to their treatment. Respiratory patients may benefit from closer assessment of their pain and options regarding prescribed analgesia.
Hesitation and Delay as a Social Phenomenon
Authors: Francis D. Moore
Journal: New England Journal of Medicine (1973)

You cannot buy health. Although funding for health research, hospital construction and insurance are essential, expenditures in the health area will not improve the well-being of the people so long as they persist in building oversized automobiles that kill at high speeds, pollute the air and water, overindulge in drugs, alcohol and tobacco, overconsume fats and calories and leave grinding poverty and stupid ignorance untouched. Even the most expensive use of hospital time known as the "executive checkup" won't bring health if the same executive fractures both femurs during the next evening while driving home after a cocktail party.One . . .
BMA calls for amended health bill to be withdrawn
Authors: Z. Kmietowicz
Journal: BMJ (2011)

The BMA has said it will launch a public campaign to call for the withdrawal of the Health and Social Bill because of continuing concerns among doctors about key aspects of the changes planned for the health service despite amendments after the government’s listening exercise.

At a council meeting on 20 July the BMA rejected the idea that the government’s proposed changes to the bill will substantially reduce the risk of further marketisation and privatisation of the NHS. It said that the government was misleading the public by repeatedly stating that there will be no privatisation of the NHS.

In a statement issued after the meeting Hamish Meldrum, chairman of council at the …
Effect of a Barbiturate Antagonist in Chronic Barbiturate Intoxication
Authors: K. N. V. Palmer
Journal: BMJ (1956)

BRDITAIJSOUNAL 1219 living in hotels or institutions.The incidence of vascular diseases of the nervous system in these boroughs, corrected for age and sex, is much the same as in the rest of London, but the factors mentioned in Kensington and Westminster would increase the pressure on beds, since many patients have no one at home to look after them.
Editorial Peer Review in Biomedical Publication
Authors: Drummond Rennie
Journal: JAMA (1990)

In May 1989, the American Medical Association sponsored The First International Congress on Peer Review in Biomedical Publication. This issue of<i>JAMA</i>is dedicated to papers first presented at that congress, themselves greatly modified by editorial peer review. We at<i>JAMA</i>, considering that publication lies at the heart of the scientific process and that at the heart of publication lies peer review,<sup>1</sup>were impressed by the evident lack of research<sup>2</sup>into a process that occupies our energies daily and on which we, as editors, are disposed to rely heavily. We recognized that the vast majority of papers written about editorial peer review had been composed in the absence of any data and were editorial effusions that expressed individual biases. Scientific investigations in this field were woefully lacking, and we set out to change this state of affairs.<sup>3</sup> Our objectives in holding the congress were simple: to stimulate
Hepatitis E: Does it cause chronic hepatitis?
Authors: Rakesh Aggarwal, Kris Kowdley, Geoffrey McCaughan, Christian Trautwein
Journal: Hepatology (2008)

Hepatitis E virus (HEV) is considered an agent responsible for acute hepatitis that does not progress to chronic hepatitis. We identified 14 cases of acute HEV infection in three patients receiving liver transplants, nine receiving kidney transplants, and two receiving kidney and pancreas transplants. All patients were positive for serum HEV RNA. Chronic hepatitis developed in eight patients, as confirmed by persistently elevated aminotransferase levels, serum HEV RNA, and histologic features of chronic hepatitis. The time from transplantation to diagnosis was significantly shorter and the total counts of lymphocytes and of CD2, CD3, and CD4 T cells were significantly lower in patients in whom chronic disease developed.