tbuckley/cabot-search huggingface dataset:
DIFFERENTIAL DIAGNOSIS OF DISEASES OF THE LIVER
Authors: B. B. Vincent Lyon
Journal: Annals of Internal Medicine (1935)

Article1 September 1935DIFFERENTIAL DIAGNOSIS OF DISEASES OF THE LIVERB. B. VINCENT LYON, F.A.C.P.B. B. VINCENT LYON, F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-9-3-258 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptAn adequate discussion of the differential diagnosis of liver disease would have to consider the following groups:1. Hepatitis, toxic and infectious.2. Hepatocholangitis.3. Hepatic-intestinal toxemia.4. Simple hepatic cirrhosis.5. Pigmented cirrhosis with anthracosis.6. Cirrhosis with hemochromatosis.7. Kinnear-Wilson cirrhosis.8. So-called Banti's disease.9. So-called Tropical Liver.10. Cancer of the liver.11. Syphilis of the liver (relatively common).12. Tuberculosis of the liver (comparatively rare).13. Hydatid cysts (dog disease) and other cysts.14. Distomiasis or liver fluke (sheep or fish disease).15. Trematode or other parasitic disease.16. Amebic abscess.17. Various bacterial abscesses....Bibliography1. LYONSWALM BBWA: The therapeutic value of non-surgical drainage of the biliary tract, Jr. Am. Med. Assoc., 1925, lxxxv, 1541-1548. CrossrefGoogle Scholar2. LYONSWALMBARTLESTERNER BBWAHJRF: Therapeutic effectiveness of dehydrocholic acid in liver and biliary tract disease, Med. Rec., 1934, cxxxix, 123-128. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Philadelphia, Pennsylvania*Read at the Philadelphia meeting of the American College of Physicians, May 1, 1935. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 September 1935Volume 9, Issue 3Page: 258-263KeywordsAbscessesAmebiasisCirrhosisEchinococcosisHemochromatosisInfectious hepatitisLiverLiver diseasesParasitic diseasesSyphilis ePublished: 1 December 2008 Issue Published: 1 September 1935 PDF downloadLoading ...
Phylogeny of the Insect Homeobox Gene (Hox) Cluster
Authors: Sangeeta Dhawan, K.P. Gopinathan
Journal: Genomics Proteomics & Bioinformatics (2005)

Abstract The homeobox (Hox) genes form an evolutionarily conserved family encoding transcription factors that play major roles in segmental identity and organ specification across species. The canonical grouping of Hox genes present in the HOM-C cluster of Drosophila or related clusters in other organisms includes eight “typical” genes, which are localized in the order labial (lab), proboscipedia (pb), Deformed (Dfd), Sex combs reduced (Scr), Antennapedia (Antp), Ultrabithorax (Ubx), abdominalA (abdA), and AbdominalB (AbdB). The members of Hox cluster are expressed in a distinct anterior to posterior order in the embryo. Analysis of the relatedness of different members of the Hox gene cluster to each other in four evolutionarily diverse insect taxa revealed that the loci pb/Dfd and AbdB, which are farthest apart in linkage, had a high degree of evolutionary relatedness, indicating that pb/Dfd type anterior genes and AbdB are closest to the ancestral anterior and posterior Hox genes, respectively. The greater relatedness of other posterior genes Ubx and abdA to the more anterior genes such as Antp and Scr suggested that they arose by gene duplications in the more anterior members rather than the posterior AbdB.
Glucose sensing O-GlcNAcylation pathway regulates the nuclear bile acid receptor farnesoid X receptor (FXR)
Authors: Wahiba Berrabah, Pierrette Aumercier, Céline Gheeraert, Hélène Dehondt, Emmanuel Bouchaert, Jérémy Alexandre, Maheul Ploton, Claire Mazuy, Sandrine Caron, Anne Tailleux, Jérôme Eeckhoute, Tony Lefebvre, Bart Staels, Philippe Lefebvre
Journal: Hepatology (2013)

Bile acid metabolism is intimately linked to the control of energy homeostasis and glucose and lipid metabolism. The nuclear receptor farnesoid X receptor (FXR) plays a major role in the enterohepatic cycling of bile acids, but the impact of nutrients on bile acid homeostasis is poorly characterized. Metabolically active hepatocytes cope with increases in intracellular glucose concentrations by directing glucose into storage (glycogen) or oxidation (glycolysis) pathways, as well as to the pentose phosphate shunt and the hexosamine biosynthetic pathway. Here we studied whether the glucose nonoxidative hexosamine biosynthetic pathway modulates FXR activity. Our results show that FXR interacts with and is O-GlcNAcylated by O-GlcNAc transferase in its N-terminal AF1 domain. Increased FXR O-GlcNAcylation enhances FXR gene expression and protein stability in a cell type-specific manner. High glucose concentrations increased FXR O-GlcNAcylation, hence its protein stability and transcriptional activity by inactivating corepressor complexes, which associate in a ligand-dependent manner with FXR, and increased FXR binding to chromatin. Finally, in vivo fasting-refeeding experiments show that FXR undergoes O-GlcNAcylation in fed conditions associated with increased direct FXR target gene expression and decreased liver bile acid content. FXR activity is regulated by glucose fluxes in hepatocytes through a direct posttranslational modification catalyzed by the glucose-sensing hexosamine biosynthetic pathway.
Late-breaking abstract: Prevalence of emphysema heterogeneity measured with thoracic computed tomography soft in combination with collateral ventilation assessment to plan endoscopic volume reduction
Authors: Christophe Pison, Adrien Jankowski, Sébastien Quétant, Marie Jondot, Cécile Chérion, Gilbert Ferretti, Wahju Aniwidyaningsih
Journal: European Respiratory Journal (2011)

Functional improvements after endoscopic volume reduction in severe emphysema were related to lobar heterogeneity and integrity of fissures in a post-hoc analysis of VENT data, NEJM 2010;363:1233. In 101 consecutive patients referred for endoscopic volume reduction, irrespective of CT findings, with FEV1   50% destruction and a difference > 10% in destruction within lobes was found in 43 cases, 22 instances in left side, 31 right side, 15 both sides with no collateral ventilation in 83%. The first patients with no collateral ventilation treated with valves experienced major improvements in 80% in terms of FEV1, FVC and weight gain. We conclude that in patients with severe emphysema, heterogeneity was found in 43% of cases. From this single centre experience, endoscopic volume reduction seemed to result in meaningful improvements in 0.43x0.83x0.80 corresponding to 29% of cases. Funds from 2008-2010 innovative hospital grants.
Vav3, a Rho GTPase guanine nucleotide exchange factor, represents a potential novel therapeutic target for breast cancer
Authors: fabrice andre, bailang wang, christos Hatzis, ludovic lacroix, chafika mazouni, christos sotiriou, frazer symmans, Stacy Moulder, Lajos Pusztai
Journal: Cancer Research (2007)

AACR Annual Meeting-- Apr 14-18, 2007; Los Angeles, CA

4422 

Background. The goal of this project was to analyze human breast cancer gene expression data to identify novel therapeutic targets. We searched for genes with marked and consistent bimodal expression in multiple microarray date sets and took promising candidates to the laboratory for in vitro validation.

Material and Methods. We used Silverman’s smoothed bootstrap test for unimodality to identify bimodally expressed genes in (i) MD Anderson set of 147 arrays, (ii) Erasmus set of 286 arrays (Wang et al, Lancet, 2005). Expression data was generated with Affymetrix U133A Genechips. VAV3 was selected for further in vitro studies because it was consistently bimodally expressed and has been previously involved in cell proliferation and signal transduction in non-malignant cells. VAV3 protein expression was examined in 8 breast cancer cell lines in vitro. The effects of VAV3 downregulation (siRNA) on cell proliferation and kinase pathways were assessed.

Results. Western blot analyses showed that VAV3 was expressed in two breast cancer cell lines (MDA453 and T47D). Both transient and stable transfections with a VAV3 specific siRNA decreased cell proliferation of T47D and MDA453 cell lines. Stimulation of VAV3-expressing cell lines by EGF induced VAV3 phosphorylation. VAV3 downregulation decreased phosphorylation of PAK1 (ser144) and ER (ser 118). Since VAV3 is involved in Rac1 pathway activation, we further hypothesized that targeting Rac1 by specific inhibitors ([NSC23766][1], Nat Med, 2005) could lead to cell growth decrease in VAV3+ cell lines. The exposure of VAV3+ cell lines (T47D and MDA453) to 50 μmol/l of [NSC23766][1] (IC50 for rac1 inhibition) decreased by 80 to 90% the cell survival at day 4.

Conclusion. Analysis of bimodally expressed genes in breast cancer leads to the identification of VAV3 and downstream pathway (Rac1) as potential targets for therapeutic intervention.

 [1]: /lookup/external-ref?link_type=GENPEPT&access_num=NSC23766&atom=%2Fcanres%2F67%2F9_Supplement%2F4422.atom
Abstract 11963: Randomized Ivus Comparison Between a Durable and a Biodegradable-Polymer Second Generation Drug-Eluting Stents: The Bioactive Trial
Authors: Jose de Ribamar Costa, Breno Almeida, Ricardo Costa, Daniel Chamie, Marco Perin, Andrea Abizaid, Amanda Sousa, Alexandre Abizaid
Journal: Circulation (2014)

Background: New generation drug-eluting stents (DES), biolimus-eluting stents (BES) and everolimus-eluting stents (EES) were conceived to minimize local coronary inflammation allowing better endothelial healing. The aim of this study is to compare the IVUS patterns observed with both stents at midterm follow-up. Methods: The Bioactive trial is a multicentre, randomized trial (1:1) comparing BES and EES based on surrogate safety and efficacy endpoints. Inclusion criteria was single, de novo lesions in native coronary arteries of 3.0 to 3.5mm and maximum lesion length of 20 mm. Patients with in-stent restenosis, lesion in grafts and treated in the setting of STEMI were excluded. The present analysis aims to compare the main IVUS findings for both DES at 9-month invasive follow-up. IVUS analyses were performed in an independent corelab blinded to the type of DES used. Results: A total of 40 patients were enrolled in the trial and 35 had IVUS performed. Procedure success was achieved in all cases. Baseline clinical characteristics as well as reference vessel diameter and lesion length did not significantly differ between the 2 cohorts. At 9 month, QCA measured in stent late loss was also comparable (0.15±0.18mm for BES vs. 0.20±0.47mm for EES, p=0.7). By IVUS, vessel volume (349±158mm3 for BES vs. 326±127mm3 for EES, p=0.6) and stent volume (178±78 for BESmm3 vs. 154±54mm3 for EES, p=0.4) did not significantly differ between the groups as well as neointimal tissue volume (3.6±2.8mm3 for BES vs 4.3±6.1mm3 for EES, p=0.4) and the % of stent obstruction (2.3±2.1% for BES vs. 2.5±2.8% for EES. OF note, the pattern of neointimal distribution was very similar between the two DES (figure). Conclusions: In this head-to-head to comparison, both second-generation DES were shown to be effective and safety in the treatment of coronary artery disease with no significant differences in terms of IVUS findings.
Erythrocyte fatty acids and fatty acid synthase expression in benign and malignant prostate
Authors: Jackilen Shannon, Christopher Corless, Amy Palma, Laura Peters, Jutta Deininger, Cara Poage, Philippe Thuillier, Mark Garzotto
Journal: Clinical Cancer Research (2008)

A40    Objectives:  Dysregulation of fatty acid synthase (FAS) may have early influences on prostate carcinogenesis. FAS, a multienzyme that catalyzes de novo fatty acid synthesis, is highly expressed in prostate cancer, and is correlated with greater disease severity. In normal cells FAS transcription is regulated by nutrients, including fatty acids. However, in cancer cell lines FAS transcription becomes autonomously regulated. In the current analyses, we address the hypothesis that FAS is overexpressed in malignant as opposed to benign prostate tissue and that FAS expression is associated with variations in erythrocyte (ERC) fatty acid concentrations.   Methods:  In this translational study, we used population methods to investigate a biologic mechanism for cancer progression. Information on diet and other risk factors was obtained from consented patients referred for clinical suspicion of prostate cancer. Blood specimens were obtained prior to prostate biopsy, and ERC fatty acid concentrations were determined using GC-MS. Sections of residual formalin-fixed, paraffin-embedded tissues were prepared, including benign tissue from biopsy-positive cases and biopsy-negative controls and when present, invasive adenocarcinoma. FAS expression was assessed by standard immunohistochemistry, and the slides were scored for percent of glands stained, average staining intensity and range of staining intensity. Summary scores were calculated and the difference in FAS expression between tissues was determined by t-test. General linear regression was used to model the association between FAS expression in benign, surrounding benign and malignant tissue and ERC fatty acid levels. Final regression models were adjusted for age, total caloric intake and PSA.   Results:  Data were analyzed for 148 controls with biopsies negative for tumor and 70 incident prostate cancer cases; 61 of whom had adequate tumor and benign tissue for comparison. Mean FAS staining was significantly greater in malignant tissue (8.54 +/- 4.29 as compared to both surrounding benign (3.46 +/-2.86) and benign tissue from biopsy negative controls (3.28 +/- 2.71, p Conclusions:  Our results show that there was no association between ERC fatty acid levels and prostate tumor tissue FAS expression. However, ERC fatty acid levels were associated with alterations of FAS expression in the benign component of men with cancer.  Overall, our findings suggest that in benign tissue FAS expression may still be regulated via nutritional controls providing a mechanism by which fatty acids may alter risk of progression of prostatic epithelium from the benign to the malignant state.
Regularly Updated Drug Product Safety Information on the Internet
Authors: Stuart L. Nightingale
Journal: JAMA (1999)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Marijuana Arrests and Increase in Marijuana Use Disorders—Reply
Authors: Wilson M. Compton, James D. Colliver, Meyer D. Glantz, Bridget F. Grant, Frederick S. Stinson
Journal: JAMA (2004)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Dangers in Use of Some Potent Drugs
Authors: W B Spaulding
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Nut Consumption and Risk of Type 2 Diabetes
Authors: Emily D. Parker, Lisa J. Harnack, Aaron R. Folsom
Journal: JAMA (2003)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The effect of excimer laser photorefractive keratectomy for myopia on nerve fiber layer thickness measurements as determined by scanning laser polarimetry11The authors have no proprietary interest in any product discussed in this article.The views and opinions expressed herein are those of the authors and are not to be construed as official views of the Department of the Navy, the Department of Defense, or of the United States Government. No commercial endorsement of any product by the United …
Authors: Neil T Choplin, Steven C Schallhorn
Journal: Ophthalmology (1999)
ABC of General Surgery in Children: ACUTE ABDOMINAL PAIN IN CHILDREN
Authors: M. Davenport
Journal: BMJ (1996)

Principles of diagnosis -*.....Ah with acute abdominal pain can be a disconcerting experience for most doctors, and there is often little in the way of aids or Operation Observed ~~investigations that can be used to arrive at a correct diagnosis.m(n=126 (35X)) 7 :(n=237 (65%)) m Certainly there are common conditions that cause problems in most age groups (such as appendicitis) and others that are usually confined ~~~~~~~to a specific age group (such as intussusception).doctor, and, of those that do, most being seen and treated at home by a general practitioner.Of those that are taken to hospital, some recover without obvious sequelae despite the lack of a specific diagnosis.The label non-specific abdominal pain has been used for these cases, and this, in truth, will be the commonest "cause" of most acute abdominal Diagnostic breakdown of one year's admissions for pain that most clinicians will see.abdominal pain in a district general hospital (after Jones'). Clinical approachSymptoms associated with An accurate history is vital, although in younger children it is usually Symptoms associated with | hearsay.Important points are the length of the current illness; previous surgically correctable causes of similar episodes; periodicity if it is a colicky pain; whether it is acute abdominal pain constant, worsening, or getting better; and any related or aggravating * Vomiting of bile factors.Gastrointestinal upset (such as vomiting) is common and can * Asymmetric pain be a non-specific feature.The presence of bile in vomit is an important * Local tenderness discriminant suggesting intestinal obstruction.Alternatively, ______Peritonism ____________________ substantial diarrhoea can accompany surgical pathology and should not be accepted simply as enteritis.Urinary symptoms such as dysuria and frequency can be difficult to establish in young children and again can also be entirely erroneous-both are common in a child with a ......... !pelvic appendicitis.
AIDS is largest cause of maternal deaths in South Africa
Authors: Pat Sidley
Journal: BMJ (2000)

HIV/AIDS is the most common cause of death among women in pregnancy and childbirth, according to research carried out by the South African government.

The research, which looked at deaths among women in pregnancy and childbirth (maternal deaths) in 1999, follows a report last year that found that there were 150 maternal deaths for every 100 000 live births in 1998; an ongoing “confidential enquiry into maternal deaths” was launched as a result. The latest report does not give an equivalent figure for 1999.

The new report does show, however, that in 1999 29.6% of …
HOOKWORM AND OTHER INTESTINAL PARASITES IN ECUADOR
Authors: E. Ray Royer
Journal: JAMA (1920)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal