tbuckley/cabot-search huggingface dataset:
AGGLUTINATING EFFICIENCY AND COMBINING CAPACITY OF SHIGELLA AND VIBRIO ANTISERA FROM RABBITS AT DIFFERENT STAGES OF IMMUNIZATION
Authors: Rolf Freter
Journal: The Journal of Experimental Medicine (1957)

Studies of the relative combining capacities of different antisera to Vibrio cholerae and Shigella flexneri were carried out using the Talmage test. In this test the absorption of an I(131) labelled antibody preparation by antigen is blocked by the addition of unlabelled unknown serum. Sera from rabbits in the early stages of immunization ("early antisera") had a high agglutinin titer, but low combining capacity. Sera from hyperimmune rabbits ("late antisera") had higher combining capacities than early antisera, but similar or lower agglutinin titers. More antigen was needed to absorb the agglutinins from late antisera than from early ones of the same agglutinin titer, indicating that late antisera contained relatively more antibody. At high concentrations, sera from hyperimmune rabbits agglutinated the homologous antigen more rapidly than did early antisera, even though early sera had similar or higher agglutinin titers. Sera drawn after the anamnestic response to bacterial antigen had the characteristics of late sera; i.e., their combining capacities were high. The possible significance of these findings for the in vitro estimation of protective antibody is discussed.
Analyzing Effectiveness of Long-term Psychodynamic Psychotherapy
Authors: Aaron T. Beck
Journal: JAMA (2009)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
P911 GLOMERULAR FILTRATION RATE DETERMINED BY CKD-EPI-CYSTATIN C EQUATION, BUT NOT WITH MDRD4 OR CKD-EPI-CREATININ, IS ASSOCIATED WITH LONG TERM SURVIVAL AFTER LIVER TRANSPLANTATION
Authors: T. Uguen, C. Jezequel, P. Houssel, M. Latournerie, K. Boudjema, D. Guyader, E. Bardou-Jacquet
Journal: Journal of Hepatology (2014)
Anticentromere antibody in patients without CREST and scleroderma: association with active digital vasculitis, rheumatic and connective tissue disease.
Authors: J A Goldman
Journal: Annals of the Rheumatic Diseases (1989)

This paper looks at the problem confronting a doctor evaluating a patient with anticentromere antibody who does not have evidence of disease along the spectrum from CREST (calcinosis, Raynaud's phenomenon, oesophageal dysmotility, sclerodactyly, telangiectasia) to progressive systemic sclerosis. Of 33 people with anticentromere antibody, 21 had CREST and two had scleroderma. Of the other 10 with a positive anticentromere antibody, three had systemic lupus erythematosus (two with digital vasculitis), three very active seronegative polyarthritis, three Raynaud's phenomenon, and one a claudication syndrome involving the legs. A positive antinuclear antibody test does not always indicate the presence of a connective tissue disease, but the presence of anticentromere antibody without systemic sclerosis or CREST often indicates the presence of another sometimes serious underlying rheumatic or connective tissue disease.
Influenza Immunization and Lupus Erythematosus
Authors: L. FRED AYVAZIAN
Journal: Annals of Internal Medicine (1979)

Letters and Corrections1 January 1979Influenza Immunization and Lupus ErythematosusL. FRED AYVAZIAN, M.D.L. FRED AYVAZIAN, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-90-1-127_2 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: In four papers in the June 1978 issue, Drs. Williams, Brodman, Ristow, and Louie (all with coauthors) (1-4) report data and separately endorse the safety of influenza vaccination for persons with systemic lupus erythematosus, a view balanced with cautionary comments in a summarizing editorial by Drs. Hess and Hahn (5). Reference is made to Ayvazian's and Badger's report of lupus erythematosus among vaccinated student nurses (6), but the immunization patterns that we described were not at all duplicated by these new studies.These papers in the June issue are being quoted at conferences and cited by science...References1. WILLIAMSSTEINBERGREINERTSENKLASSENDECKERDOLIN GAJLJR: Influenza immunization in systemic lupus erythematosus. A double-blind trial. Ann Intern Med 88:729-734, 1978 LinkGoogle Scholar2. BRODMANGILFILLANGLASSSCHUR RRDP: Influenza vaccine response in systemic lupus erythematosus. Ann Intern Med 88:735-740, 1978 LinkGoogle Scholar3. RISTOWDOUGLASCONDEMI SRJ: Influenza vaccination of patients with systemic lupus erythematosus. Ann Intern Med 88:786-789, 1978 LinkGoogle Scholar4. LOUIENIESSHOJIFRABACKABRASSBORDERCHERRYIMAGAWA JKKRCWJD: Clinical and antibody responses after influenza immunization in systemic lupus erythematosus. Ann Intern Med 88:790-792, 1978 LinkGoogle Scholar5. HESSHAHN EB: Influenza immunization in lupus erythematosus: safe, effective? (editorial). Ann Intern Med 88:833-834, 1978 LinkGoogle Scholar6. AYVAZIANBADGER LT: Disseminated lupus erythematosis occurring among student nurses. N Engl J Med 239:1-18, 1948 CrossrefMedlineGoogle Scholar7. SLE patients are safely vaccinated against Flu in two test studies. Infect Dis 8:18 1978 Google Scholar8. AYVAZIAN L: Risks of repeated immunization (letter). Ann Intern Med 82:589, 1975 LinkGoogle Scholar9. ZIFF M: Viruses and the connective tissue diseases. Ann Intern Med 75:951-958, 1971 LinkGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: College of Medicine and Dentistry of New Jersey Piscataway, New Jersey 08854 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByCorrection: Address of Dr. L. Fred Ayvazian 1 January 1979Volume 90, Issue 1Page: 127-128KeywordsLupus erythematosusResearch designSafety Issue Published: 1 January 1979 PDF DownloadLoading ...
Islamic State executes 10 doctors for refusing to treat its wounded fighters
Authors: S. Arie
Journal: BMJ (2015)

Militants in the self proclaimed Islamic State (IS) have reportedly executed 10 doctors near the Iraqi city of Mosul after they refused to treat wounded IS fighters.

Iranian and Iraqi media quoted an unnamed local source who said that the doctors were killed in Hammam al-Alil, a desert area 24 km south of the city of Mosul that has been in IS control since last June. PressTV, a 24 hour English news service owned by Iran, which opposes …
SOME UNUSUAL FORMS OF DYSENTERY
Authors: G. C. Low
Journal: BMJ (1920)

TMIcABJpoviAL 255Cadman$ in Winnipeg used a vaccine of 300 million streptococci, 200 million influenza bacilli, and 150 million pneumococci.Out of 7,600 soldiers, 4,842 were inoculated, but only about half received two doses.Of cases admitted to hospital, 6.05 per cent. of those previously inoculated developed pneumonia, against 17.1 in the uninoculated.The deaths in the uninoculated were 7.1 per cent., in tle inocu- lated 1.7 per cent., but all these had only received one dose of vaccine; there were no deaths among those who had two injections.In the civil population 24,184 received two injections; the incidence of influenza was 9.8 per cent., pneumonia 0.57 per cent., and deatlhs 0.16 per cent., as compared with 21,285 uninoculated, among whom the incidence of influenza was 24.8 per cent., pneumonia 2.2 per cent., and deaths 0.66 per cent.In England there lhas been an unnecessary timidity in the use of large doses for prophylsxis, and the original formula recommended by the War Office Conference namely, 60 million B. influtnzae, 80 million streptococci, and 200 million pneumococci in 1 c.cm.-of which it was recommended that 0.5 c.cm. should be given as a first dose and 1 c.cm. after ten days, met with considerable criticism.Nevertlheless the results, just published by Sir William Leishman,' obtained in tlle Home Commands showed that this vaccine gave some measure of protection.Of 15,624 inoculated the incidence of influenza was 14.1 per 1,000, of pulmxonary complications 1.6 per 1,000, and deaths 0.12 per 1,000, as compared with 43,520 uninoculated giving an incidence of 47.3, 13.3, and 2.25 respectively.About half the inoculated received only one dose of the vaccine.The vaccine now recommended and adopted by the Ministry of Health contains 400 million B. influenzae, 80 million streptococci, and 200 million pneumococci.Thus, whilst the dose of pneumococci and streptococci remains the same, the dose of influenza bacilli has been increased from 60 to 400 million.It would be interesting to have the reasons why this formula was adopted.
P459 RESCUE THERAPY BY AUTOLOGOUS INFUSION OF GRANULOCYTE-COLONY STIMULATING FACTOR-MOBILIZED PERIPHERAL BLOOD CD34-POSITIVE CELLS IN PATIENTS WITH DECOMPENSATED LIVER CIRRHOSIS
Authors: T. Nakamura, T. Torimura, J. Kurogi, H. Iwamoto, H. Inoue, S. Sumie, N. Fukushima, M. Sakata, H. Koga, M. Abe, Y. Ikezono, O. Hashimoto, K. Oho, T. Ueno, M. Sata
Journal: Journal of Hepatology (2014)
Letter: Salt overdosage.
Authors: R C McGouran
Journal: BMJ (1975)

enteral administration of hypertonic saline.Apparently the surgeon wished to use physio- logical saline (so-called 099% w/v) but pre- scribed "normal saline"; so the pharmacist made up normal saline (58-5 g/l), which is six times as strong, and this was given to the patient.This regrettable accident reinforces the need to abandon the use of "normal" (and of %) in medicine and in chemistry to de-
Electrocardiographic Abnormalities in Epidemic Hepatitis
Authors: L. M. SANGHVI, S. N. MISRA
Journal: Circulation (1957)

Myocarditis has been reported in patients dying with viral hepatitis. With the increasing incidence of the disease, recognition of myocardial involvement is apparently important. The nature of the abnormalities suggested several factors including ischemia and local electrolyte disturbance of myocardium. The incidence of abnormalities was greater in the out-patients and in those with tachycardia, and greatest at the peak of the epidemic. Abnormalities showed no relation to the severity of the jaundice or of the illness or to the serum protein levels.
Reversible Suprasellar Pituitary Mass Secondary to Hypothyroidism
Authors: Joycelyn A. Atchison
Journal: JAMA (1989)

Sellar enlargement and suprasellar extension of a pituitary mass, demonstrated by magnetic resonance imaging or computed tomographic scanning in three children with primary hypothyroidism, resolved after treatment with levothyroxine sodium. This condition, a logical consequence of the pathogenesis of primary hypothyroidism, must be considered in patients with pituitary and suprasellar masses.
The Marburg I variant (G534E) of the factor VII-activating protease determines liver fibrosis in hepatitis C infection by reduced proteolysis of platelet-derived growth factor BB
Authors: Hermann E. Wasmuth, Carmen G. Tag, Eddie Van de Leur, Claus Hellerbrand, Tobias Mueller, Thomas Berg, Gero Puhl, Peter Neuhaus, Didier Samuel, Christian Trautwein, Sandip M. Kanse, Ralf Weiskirchen
Journal: Hepatology (2008)

Genetic risk factors play an important role for the progression of liver fibrosis in chronic hepatitis C virus (HCV) infection, but functional data on specific alleles and their related proteins are limited. Platelet-derived growth factor BB (PDGF-BB) is one of the strongest mitogens for hepatic stellate cells and is considered as a critical soluble mediator of liver fibrosis in vitro and in vivo. The biological activity of PDGF-BB is dependent on its degradation by the factor VII-activating protease (FSAP). Here, we demonstrate that a coding polymorphism (G534E) in the gene for FSAP is significantly associated with severe HCV-induced liver fibrosis (odds ratio, 2.59; P = 0.017), which is independent of age, gender, and presence of diabetes in multivariate analysis. These genetic findings were replicated in a cohort of patients with liver transplantation due to HCV-induced cirrhosis (OR, 2.56; P = 0.011). Functional dissection of the association demonstrates that the single amino acid change encoded by G534E in the FSAP protein does not influence PDGFbeta receptor or alpha-smooth muscle actin expression but completely abrogates FSAP-mediated inhibition of PDGF-BB-induced proliferation of primary stellate cells in vitro.The G534E variant of FSAP is a risk locus for HCV-induced liver fibrosis and cirrhosis by determining PDGF-BB-mediated hepatic stellate cell proliferation through a single amino acid substitution in FSAP. FSAP G534E might be useful for risk stratification in patients with HCV infection.
Fatal Ventricular Fibrillation after Carotid-Sinus Stimulation
Authors: Hashem Hilal, Rashid Massumi
Journal: New England Journal of Medicine (1966)

SINCE the statement, "In fact, permanent cessation of the heartbeat or serious ventricular arrhythmias are almost unheard of was made by Lown and Levine1 in 1961, 2 deaths that followed carotid-sinus stimulation have been reported.2 The present communication adds a third case of fatality from ventricular fibrillation and serves as a warning against unnecessary use of this otherwise useful procedure.Case ReportA 49-year-old alcoholic cobbler was admitted to the hospital because of palpitation, nausea, vomiting and hiccups of 3 weeks' duration. The present illness was preceded by an alcoholic "binge." The past history, a careful physical examination and chest . . .
UK agency to combat research misconduct
Authors: Caroline White
Journal: BMJ (2005)

An agency to combat biomedical research misconduct in the United Kingdom is scheduled to start work in October, initially for three years, it was announced last week.

Plans for the new body, known as the UK Panel for Health and Biomedical Research Integrity, were unveiled at the annual meeting of the Committee on Publication Ethics by John Pritchard, senior planning and policy adviser at Sheffield Hallam University.

Universities UK, an organisation that promotes the work …
Renal Mucormycosis
Authors: George R. Prout, A. Robert Goddard
Journal: New England Journal of Medicine (1960)

MUCORMYCOSIS limited solely to the kidney and its vascular supply apparently has not been reported, nor has renal involvement been diagnosed except at autopsy. In the case reported below, nephrectomy and amphotericin B were utilized to affect a cure.Case ReportA 51-year-old electrician (J.M.H. 246109) entered the hospital for the 6th time, complaining of right-flank pain, dysuria, chills and fever of 5 days' and grossly bloody urine of 3 days' duration. He was addicted to alcohol and had been drinking heavily for 3 weeks before admission.Eighteen months earlier, pulmonary tuberculosis had been diagnosed, and he had received 6 . . .
A Mechanism for the Inhibition of Neural Progenitor Cell Proliferation by Cocaine
Authors: Chun-Ting Lee, Jia Chen, Teruo Hayashi, Shang-Yi Tsai, Joseph F Sanchez, Stacie L Errico, Rose Amable, Tsung-Ping Su, Ross H Lowe, Marilyn A Huestis, James Shen, Kevin G Becker, Herbert M Geller, William J Freed
Journal: PLoS Medicine (2008)

Prenatal exposure of the developing brain to cocaine causes morphological and behavioral abnormalities. Recent studies indicate that cocaine-induced proliferation inhibition and/or apoptosis in neural progenitor cells may play a pivotal role in causing these abnormalities. To understand the molecular mechanism through which cocaine inhibits cell proliferation in neural progenitors, we sought to identify the molecules that are responsible for mediating the effect of cocaine on cell cycle regulation.Microarray analysis followed by quantitative real-time reverse transcription PCR was used to screen cocaine-responsive and cell cycle-related genes in a neural progenitor cell line where cocaine exposure caused a robust anti-proliferative effect by interfering with the G1-to-S transition. Cyclin A2, among genes related to the G1-to-S cell cycle transition, was most strongly down-regulated by cocaine. Down-regulation of cyclin A was also found in cocaine-treated human primary neural and A2B5+ progenitor cells, as well as in rat fetal brains exposed to cocaine in utero. Reversing cyclin A down-regulation by gene transfer counteracted the proliferation inhibition caused by cocaine. Further, we found that cocaine-induced accumulation of reactive oxygen species, which involves N-oxidation of cocaine via cytochrome P450, promotes cyclin A down-regulation by causing an endoplasmic reticulum (ER) stress response, as indicated by increased phosphorylation of eIF2alpha and expression of ATF4. In the developing rat brain, the P450 inhibitor cimetidine counteracted cocaine-induced inhibition of neural progenitor cell proliferation as well as down-regulation of cyclin A.Our results demonstrate that down-regulation of cyclin A underlies cocaine-induced proliferation inhibition in neural progenitors. The down-regulation of cyclin A is initiated by N-oxidative metabolism of cocaine and consequent ER stress. Inhibition of cocaine N-oxidative metabolism by P450 inhibitors may provide a preventive strategy for counteracting the adverse effects of cocaine on fetal brain development.
Abstract 5622: Effect of novel RhoC inhibitor on breast cancer progression and metastasis <i>in vivo</i>
Authors: Connie R. Shi, Devin T. Rosenthal, Liwei Bao, Judy C. Pang, Zhifen Wu, Steven G. Allen, Sofia D. Merajver
Journal: Cancer Research (2012)

Abstract Introduction: The oncogene RhoC GTPase is overexpressed in highly aggressive inflammatory breast cancer (IBC) and increases cellular motility and invasiveness in mammary tissue by interacting with downstream effectors to reorganize cytoskeletal elements in the cell. A small molecule inhibitor of RhoC-effector interaction has been identified. This antagonist decreases proliferation and inhibits motility of IBC cells in vitro. Here we evaluate the in vivo effects of the novel RhoC antagonist in a transgenic mouse model of breast cancer. Methods: The PyMT-RhoC transgenic mouse model was used in this study. This double transgenic strain was created by crossing the polyoma middle T antigen (PyMT) breast cancer model to a RhoC-overexpressing strain driven by the mouse mammary tumor virus (MMTV) promoter. The RhoC inhibitor was administered by intraperitoneal injection beginning at 50 days of age. Tumor size was monitored throughout treatment. At the end of the treatment, mammary glands, tumors, and lungs were extracted, fixed, sectioned, and stained with H&amp;E. Results: PyMT-RhoC mice treated with the RhoC inhibitor showed a statistically significant delay in time of onset of the primary tumor and exhibited slower growth of the primary tumor compared to the control group. Western blot showed decreased RhoC protein levels in the treated PyMT-RhoC group relative to control, suggesting that the drug's in vivo activity includes reducing RhoC protein expression. Finally, as determined through H&amp;E staining of lung sections, tumor metastasis to the lungs was decreased in the treated group compared to age-matched controls. Conclusions: We conclude that this novel RhoC antagonist shows promise in vivo as an inhibitor of mammary tumor proliferation and metastasis, and has the potential to be a clinically relevant treatment for inflammatory breast cancer. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 103rd Annual Meeting of the American Association for Cancer Research; 2012 Mar 31-Apr 4; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2012;72(8 Suppl):Abstract nr 5622. doi:1538-7445.AM2012-5622
801-2 Predictors of survival after primary percutaneous coronary intervention: The impact of myocardial perfusion grade in female patients
Authors: Ricardo A Costa, Alexandra J Lansky, Costantino O Costantini, Yoshihiro Tsuchiya, Calin Caluser, Bahran Sahid, Martin Fahy, Eugenia Nikolsky, Eve Aymong, Manuela Negoita, Roxana Mehran, David A Cox, Cindy L Grines, Gregg W Stone
Journal: Journal of the American College of Cardiology (2004)
Peffers Watson Brown
Authors: A. Geddes
Journal: BMJ (2013)

Myelination and voltage-gated ion channel clustering at the nodes of Ranvier are essential for the rapid saltatory conduction of action potentials. Whether myelination influences the structural organization of the axon initial segment (AIS) and action potential initiation is poorly understood. Using the cuprizone mouse model, we combined electrophysiological recordings with immunofluorescence of the voltage-gated Nav1.6 and Kv7.3 subunits and anchoring proteins to analyze the functional and structural properties of single demyelinated neocortical L5 axons. Whole-cell recordings demonstrated that neurons with demyelinated axons were intrinsically more excitable, characterized by increased spontaneous suprathreshold depolarizations as well as antidromically propagating action potentials ectopically generated in distal parts of the axon. Immunofluorescence examination of demyelinated axons showed that βIV-spectrin, Nav1.6, and the Kv7.3 channels in nodes of Ranvier either dissolved or extended into the paranodal domains. In contrast, while the AIS in demyelinated axons started more closely to the soma, ankyrin G, βIV-spectrin, and the ion channel expression were maintained. Structure–function analysis and computational modeling, constrained by the AIS location and realistic dendritic and axonal morphologies, confirmed that a more proximal onset of the AIS slightly reduced the efficacy of action potential generation, suggesting a compensatory role. These results suggest that oligodendroglial myelination is not only important for maximizing conduction velocity, but also for limiting hyperexcitability of pyramidal neurons.
Patient-oriented gene set analysis for cancer mutation data
Authors: Simina M Boca, Kenneth W Kinzler, Victor E Velculescu, Bert Vogelstein, Giovanni Parmigiani
Journal: Genome biology (2010)

Abstract Recent research has revealed complex heterogeneous genomic landscapes in human cancers. However, mutations tend to occur within a core group of pathways and biological processes that can be grouped into gene sets. To better understand the significance of these pathways, we have developed an approach that initially scores each gene set at the patient rather than the gene level. In mutation analysis, these patient-oriented methods are more transparent, interpretable, and statistically powerful than traditional gene-oriented methods.