tbuckley/cabot-search huggingface dataset:
Leukotriene Receptor Antagonists and Synthesis Inhibitors Reverse Survival in Eosinophils of Asthmatic Individuals
Authors: ELAINE LEE, TRACY ROBERTSON, JACQUELINE SMITH, STEPHEN KILFEATHER
Journal: American Journal of Respiratory and Critical Care Medicine (2000)

Eosinophilia is a feature of airway inflammation associated with asthma. Leukotriene antagonists provide therapeutic benefit in asthma, but their potential antiinflammatory actions have not been fully explored. We have examined the role of eosinophil-derived cysteinyl leukotrienes in the maintenance of eosinophil survival, and the involvement of leukotrienes in the paracrine stimulation of eosinophil survival by mast cells and lymphocytes. We obtained eosinophils and autologous lymphocytes from peripheral blood of asthmatic subjects. Leukotriene (LT)-B(4), LTC(4) and LTD(4), granulocyte-macrophage colony-stimulating factor (GM-CSF), and fibronectin promoted eosinophil survival. LTD(4) (10(-)(6) M) was as effective as GM-CSF (5 ng/ml) and fibronectin (400 ng/ml) in promoting survival. Lymphocytes and conditioned medium from a human mast cell line (HMC-1) induced eosinophil survival. Blockade of cysteinyl leukotriene receptors with SKF 104353 (pobilukast, 3 nM), and inhibition of 5-lipoxygenase (5-LO) with BW A4C (1 microM) and of 5-LO activating protein with MK 886 (1 microM), all increased basal rates of eosinophil apoptosis and reversed GM-CSF-induced eosinophil survival. Fifty percent reversal of GM-CSF- induced survival was achieved with SKF 104353 at 0.3 nM. The potency of SKF 104353 was two orders of magnitude greater than that of the LTB(4) receptor antagonist SB 201146. Mast cell- and lymphocyte-induced eosinophil survival were completely reversed by SB 201146, SKF 104353, BW A4C, and MK 886. These findings provide evidence for the involvement of an autocrine cysteinyl leukotriene pathway that supports eosinophil survival in response to a range of survival stimuli. They also suggest that LTB(4) could act as a paracrine stimulus of eosinophil survival.
Ulcero-caseous Tuberculous Bronchitis: A Method of "Spread" in Pulmonary Tuberculosis
Authors: J. W. Clegg
Journal: Thorax (1953)

<h3>Summary</h3> SARS-CoV-2 T cell response assessment and vaccine development may benefit from an approach that considers the global landscape of the human leukocyte antigen (HLA) proteins. We predicted the binding affinity between 9-mer and 15-mer peptides from the SARS-CoV-2 peptidome for 9,360 class I and 8,445 class II HLA alleles, respectively. We identified 368,145 unique combinations of peptide-HLA complexes (pMHCs) with a predicted binding affinity less than 500nM, and observed significant overlap between class I and II predicted pMHCs. Using simulated populations derived from worldwide HLA frequency data, we identified sets of epitopes predicted in at least 90% of the population in 57 countries. We also developed a method to prioritize pMHCs for specific populations. Collectively, this public dataset and accessible user interface (Shiny app: https://rstudio-connect.parkerici.org/content/13/) can be used to explore the SARS-CoV-2 epitope landscape in the context of diverse HLA types across global populations.
327 MICRO-RNA-221 REGULATES P27/KIP1 IN HEPATOCELLULAR CARCINOMA
Authors: F. Fornari, L. Gramantieri, M. Ferracin, S. Sabbioni, A. Veronese, C. Giovannini, M. Galassi, G.L. Grazi, M. Negrini, L. Bolondi
Journal: Journal of Hepatology (2008)
Squamous cell carcinoma of the tongue complicating chronic oral mucosal graft‐versus‐host disease after allogeneic hematopoietic stem cell transplantation
Authors: Ching H. Szeto, Tony W.H. Shek, Albert K.W. Lie, Wing Y. Au, Anthony P.W. Yuen, Yok L. Kwong
Journal: American Journal of Hematology (2004)

Abstract Two patients underwent allogeneic hematopoietic stem cell transplantation (HSCT) for acute myeloid leukemia. Chronic graft‐versus‐host disease (GVHD) developed, with persistent symptomatic oral lesions. At 2 and 6 years post‐HSCT, both patients developed squamous cell carcinoma (SCC) of the tongue in areas previously involved by chronic GVHD. None had any known risk factor for SCC. Histologically, moderate to severe dysplasia was present in noncancerous oral mucosa. Oral SCC is rarely described after HSCT, and a review of the reported cases showed chronic GVHD to be a common risk, suggesting that the chronic inflammation associated with GVHD might be of pathogenetic significance. Am. J. Hematol. 77:200–202, 2004. © 2004 Wiley‐Liss, Inc.
Case 1-1977
Authors: Richard C. Cabot, Robert E. Scully, James J. Galdabini, Betty U. McNeely, Robert A. Johnson, Terence J. Harrist
Journal: New England Journal of Medicine (1977)

Presentation of CaseA 45-year-old man was admitted to the hospital after collapsing.The patient was apparently well until one day before admission, when he experienced pain in the right leg. On the next day he recalled sitting down somewhere and remembered nothing else until he regained consciousness in the Emergency Ward, where he was brought by police who found him collapsed on a street corner.He was an obese man who appeared apneic on arrival at the Emergency Ward, although the pulse was palpable; he promptly began to breathe with effort. The temperature was not recorded. The pulse was . . .
Serum Calcium After Therapeutic Head and Neck Irradiation
Authors: Paul C. Royce, Bruce R. Mackay, Petrina M. Disabella
Journal: Annals of Internal Medicine (1980)

Letters1 July 1980Serum Calcium After Therapeutic Head and Neck IrradiationPAUL C. ROYCE, M.D., PH.D., BRUCE R. MACKAY, M.D., PETRINA M. DISABELLA, R.N., M.B.A.PAUL C. ROYCE, M.D., PH.D.Search for more papers by this author, BRUCE R. MACKAY, M.D.Search for more papers by this author, PETRINA M. DISABELLA, R.N., M.B.A.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-93-1-146 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: Hyperparathyroidism has been linked to therapeutic irradiation of the head and neck. This linkage is based on isolated case reports (1) and on series of patients with surgically proven hyperparathyroidism in which as many as 30% had received head-and-neck irradiation (2). While suggesting a cause and effect relation, these reports provide no information on the incidence of hyperparathyroidism in an irradiated cohort. We recently measured the serum calcium concentration in 214 persons with documented head-and-neck irradiation and in 243 control subjects as part of a program to evaluate the late effects of irradiation. Details of irradiation dose,...References1. SCHACHNERHALL SA. Parathyroid adenoma and previous head-and-neck irradiation. Ann Intern Med. 1978;88:804. LinkGoogle Scholar2. PALOYANLAWRENCEPRINZPICKLEMANBRAITHWAITEBROOKS EARJSM. Radiation-associated hyperparathyroidism. Lancet. 1977; 1:949. Letter. CrossrefMedlineGoogle Scholar3. ROYCEMACKAYDISABELLA PBP. Value of postirradiation screening for thyroid nodules: a controlled study of recalled patients. JAMA. 1979;242:2675-8. CrossrefMedlineGoogle Scholar4. DARLINGTON R. Radicals and Squares. Ithaca, New York: Logan Hill Press; 1975;106-7. Google Scholar5. CHRISTENSSONHELLSTRÖMWENGLEALVERYDWIKLAND TKBAB. Prevalence of hypercalcemia in a health screening in Stockholm. Acta Med Scand. 1976;200:131-7. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 July 1980Volume 93, Issue 1_Part_1Page: 146-147KeywordsAttentionCalciumHyperparathyroidism Issue Published: 1 July 1980 PDF DownloadLoading ...
<i>NUP98</i> Is Fused to Topoisomerase (DNA) IIβ 180 kDa (<i>TOP2B</i>) in a Patient with Acute Myeloid Leukemia with a New t(3;11)(p24;p15)
Authors: Karin Nebral, Helmut H. Schmidt, Oskar A. Haas, Sabine Strehl
Journal: Clinical Cancer Research (2005)

Abstract Purpose: The nucleoporin 98 kDa (NUP98) gene has been reported to be fused to 17 different partner genes in various hematologic malignancies with 11p15 aberrations. Cytogenetic analysis of an adult de novo acute myelogenous leukemia (M5a) revealed a t(3;11)(p24;p15), suggesting rearrangement of NUP98 with a novel partner gene. Experimental Design: Fluorescence in situ hybridization (FISH) was used to confirm the involvement of NUP98 in the t(3;11)(p24;p15). Selection of possible NUP98 partner genes was done by computer-aided analysis of the 3p24 region using the University of California Santa Cruz genome browser. Fusion gene–specific FISH and reverse transcription-PCR analyses were done to verify the presence of the new NUP98 fusion. Results: FISH analysis using a NUP98-specific clone showed a split signal, indicating that the NUP98 gene was affected by the translocation. Of the genes localized at 3p24, TOP2B was selected as a possible fusion partner candidate gene. Dual-color fusion gene–specific FISH and reverse transcription-PCR analysis verified that NUP98 was indeed fused to TOP2B. In addition to reciprocal NUP98-TOP2B and TOP2B-NUP98 in-frame fusion transcripts, an alternatively spliced out-of-frame TOP2B-NUP98 transcript that resulted in a premature stop codon was detected. Analysis of the genomic breakpoints revealed typical signs of nonhomologous end joining resulting from error-prone DNA repair. Conclusions: TOP2B encodes a type II topoisomerase, which is involved in DNA transcription, replication, recombination, and mitosis, and besides TOP1, represents the second NUP98 fusion partner gene that belongs to the topoisomerase gene family. This finding emphasizes the important role of topoisomerases in malignant transformation processes.
LEFT ATRIAL APPENDAGE MORPHOLOGY AND RISK OF STROKE IN PATIENTS WITH AF AND CHADS2 SCORE 0-1: IS THERE AN ASSOCIATION?
Authors: Luigi Di Biase, Pasquale Santangeli, Matteo Anselmino, Prasant Mohanty, Ilaria Salvetti, Sebastiano Gili, Rodney Horton, Javier E. Sanchez, Rong Bai, Sanghamitra Mohanty, Agnes Pump, G. Joseph Gallinghouse, J. David Burkhardt, Marco Scaglione, Andrea Natale, Fiorenzo Gaita
Journal: Journal of the American College of Cardiology (2012)
Coronary Artery Surgery in New York State
Authors: F. Andrew Morfesis
Journal: JAMA (1991)

To the Editor. —  Regarding the article by Hannan et al, 1 I do not believe that the last statement in the abstract is objective (Subsequent site visits... confirmed... high percentages of quality-of-care problems among cases resulting in mortality.).  First, the Department of Health used its own agent, a professional review organization, to perform the review: how do we know that this agent was not biased or privy to the intended conclusion in advance of the review and that this did not influence the results of the review?  Secondly, as we do not know the names of the reviewers, how can we be sure that they had nothing to gain from a more careful review of the charts of one hospital compared with another? The reviewers themselves must have been specialists who would have a personal knowledge of the hospitals being reviewed; further, being given charts of the low and
Toxic oxygen metabolite production by circulating phagocytic cells in inflammatory bowel disease.
Authors: J G Williams, L E Hughes, M B Hallett
Journal: Gut (1990)

To investigate the possibility that the oxidative capacity of phagocytic cells may be defective in inflammatory bowel disease, toxic oxygen metabolite production by circulating neutrophils and monocytes has been measured by luminol dependent chemiluminescence. Neutrophils from patients with Crohn9s disease and ulcerative colitis produced significantly lower chemiluminescent responses after chemotactic stimulation with formylmethionylleucylphenylalanine (fMLP) than neutrophils from control patients, p = 0.018 and 0.043 respectively. Chemiluminescent responses of neutrophils from patients with inflammatory bowel disease, however, were similar to control responses when cells were stimulated with latex beads or phorbol myristate acetate. Monocytes from patients with Crohn9s disease produced significantly greater levels of chemiluminescence than control monocytes when stimulated with either fMLP (p less than 0.002), phorbol myristate acetate (p less than 0.0005) or latex beads (p less than 0.002). Monocytes from patients with ulcerative colitis also produced significantly greater levels of chemiluminescence than controls when stimulated with latex beads (p less than 0.5) or phorbol myristate acetate (p less than 0.0005), although there was no difference in the level of chemiluminescence in response to fMLP. These results exclude a generalised defect in phagocytic cell oxidase activity in inflammatory bowel disease and suggest that circulating monocytes are 9activated9.
Role of controlled cardiac reoxygenation in reducing nitric oxide production and cardiac oxidant damage in cyanotic infantile hearts.
Authors: K Morita, K Ihnken, G D Buckberg, M P Sherman, H H Young, L J Ignarro
Journal: Journal of Clinical Investigation (1994)

Cardiopulmonary bypass (CPB) is used increasingly to correct cyanotic heart defects during early infancy, but myocardial dysfunction is often seen after surgical repair. This study evaluates whether starting CPB at a conventional, hyperoxic pO2 causes an "unintentional" reoxygenation (ReO2) injury. We subjected 2-wk-old piglets to ventilator hypoxemia (FIO2 approximately 0.06, pO2 approximately 25 mmHg) followed by 5 min of ReO2 on CPB before instituting cardioplegia. CPB was begun in hypoxemic piglets by either abrupt ReO2 at a pO2 of 400 mmHg (standard clinical practice) or by maintaining pO2 approximately 25 mmHg on CPB until controlling ReO2 with blood cardioplegic arrest. The effects of abrupt vs. gradual ReO2 without surgical ischemia (blood cardioplegia) were also compared. Myocardial nitric oxide (NO) production (chemiluminescence measurements of NO2- + NO3-) and conjugated diene (CD) generation (spectrophotometric A233 measurements of lipid extracts) using aortic and coronary sinus blood samples were assessed during cardioplegic induction. 30 min after CPB, left ventricular end-systolic elastance (Ees, catheter conductance method) was used to determine cardiac function. CPB and blood cardioplegic arrest caused no functional or biochemical change in normoxic (control) hearts. Abrupt ReO2 caused a depression of myocardial function (Ees = 25 +/- 5% of control). Functional depression was relatively unaffected by gradual ReO2 without blood cardioplegia (34% recovery of Ees), and abrupt ReO2 immediately before blood cardioplegia caused a 10-fold rise in cardiac NO and CD production, with subsequent depression of myocardial function (Ees 21 +/- 2% of control). In contrast, controlled cardiac ReO2 reduced NO production 94%, CD did not rise, and Ees was 83 +/- 8% of normal. We conclude ReO2 injury is related to increased NO production during abrupt ReO2, nullifies the cardioprotective effects of blood cardioplegia, and that controlled cardiac ReO2 when starting CPB to correct cyanotic heart defects may reduce NO production and improve myocardial status postoperatively.
Immunoreactive trypsinogen concentrations in infants with meconium ileus.
Authors: J G Docherty, J A Coutts, T J Evans, R Carachi
Journal: BMJ (1991)

that it is considered desirable to detect (and avoid) fetuses with Down's syndrome, the triple test is a more efficient way of doing this.Dr Bogart, on the other hand, by focusing on the costs of avoiding a birth of a baby with Down's syndrome, relative to the costs generated by such a birth is considering the cost benefit programme.Cost benefit analysis, rather than being used to compare alternative programmes, informs the decision whether to set up a programme at all, according to whether or not there is a net benefit to society.We would not wish to conjure up some arbitrary cut off cost below which it is deemed useful to set up a screening and detection programme to avoid the birth of babies with Down's syndrome.Economics cannot provide the answers to what is essentially a social ethical issue.
Long&amp;ndash;Term Follow&amp;ndash;Up of the In&amp;ndash;Flow&amp;trade; Intraurethral Insert for the Treatment of Women with Voiding Dysfunction
Authors: S. Madjar, S. Halachmi, M. Wald, E. Issaq, B. Moskovitz, M. Beyar, O. Nativ
Journal: European Urology (2000)
Stroke: Practical Management
Authors: Valery L. Feigin
Journal: JAMA (2008)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Propagating Kaposi's Sarcoma–Associated Herpesvirus
Authors: Edward S. Mocarski
Journal: New England Journal of Medicine (1997)

Over the past two years, there has been great interest in a newly recognized herpesvirus, called both Kaposi's sarcoma–associated herpesvirus (KSHV) and human herpesvirus 8. A piece of the viral genome was initially found in Kaposi's sarcoma tissue by an imaginative cloning method that identified abnormal DNA sequences.1 With only a fragmentary DNA sequence to go by, the polymerase chain reaction (PCR) was used to demonstrate this sequence in a majority of patients with AIDS-associated or classic types of Kaposi's sarcoma,1,2 as well as in two other cancers associated with AIDS — Castleman's disease and body-cavity–based lymphoma.35 In . . .
Portable ECG recorder catches syncope in the act
Authors: Beverly Merz
Journal: JAMA (1983)

There are few things more troublesome to a physician than a patient who reports frequent episodes of syncope. Often such patients are elderly, live alone, and thus have no one who can describe their symptoms or signs leading to unconsciousness. And the possible causes can be numerous—cardiac arrhythmia, epileptic seizure, response to temperature change, or gastric dumping, to name a few. Differential diagnosis often includes equipping the patient with a Holter ECG monitor to record cardiac rhythms during a 24-hour period. Of course, this procedure may be wasted unless the patient experiences syncope on the day he is wearing the monitor. However, the recent introduction of a small cardiac recorder-transmitter has allowed physicians to follow the syncope-prone patient for an extended period. The unit, which weighs approximately 4 ounces (112 g), is designed to be carried in the pocket or purse. At the onset of symptoms, the patient places the
Sandostatin® LAR®: A promising therapeutic tool in the management of acromegalic patients
Authors: I. Lancranjan, C. Bruns, P. Grass, P. Jaquet, J. Jervell, P. Kendall-Taylor, S.W.J. Lamberts, P. Marbach, H. Ørskov, G. Pagani, M. Sheppard, L. Simionescu
Journal: Metabolism (1996)
452 EFFICACY AMONG NORTH AMERICAN AND EUROPEAN HCV GENOTYPE-1 TREATMENT-NAIVE AND PREVIOUS NON-RESPONDERS AND RELAPSERS TO PEGINTERFERON/RIBAVIRIN WHEN TREATED WITH BOCEPREVIR PLUS PEGINTERFERON ALFA-2B/RIBAVIRIN
Authors: P. Marcellin, J.M. Vierling, L. Alric, M. Pirisi, A. Tran, J.K. Albrecht, C.A. Brass, N. Boparai, V. Sniukiene, M. Burroughs
Journal: Journal of Hepatology (2011)
Haiti Earthquake Relief, Phase Two — Long-Term Needs and Local Resources
Authors: Dominique Bayard
Journal: New England Journal of Medicine (2010)

Dr. Dominique Bayard worked in a makeshift hospital in Tabarre, a northeast section of Port-au-Prince, where the hospital staff treated more than 800 patients a day for infections, disabilities, complications from delayed treatment, respiratory illness, sexually-transmitted disease, and chronic disease.
P27kip1 Down-Regulation Is Associated with Trastuzumab Resistance in Breast Cancer Cells
Authors: Rita Nahta, Takeshi Takahashi, Naoto T. Ueno, Mien-Chie Hung, Francisco J. Esteva
Journal: Cancer Research (2004)

Abstract Trastuzumab (Herceptin) is a recombinant humanized monoclonal antibody directed against HER-2. The objective response rate to trastuzumab monotherapy is 12–34% for a median duration of 9 months, by which point most patients become resistant to treatment. We created two trastuzumab-resistant (TR) pools from the SKBR3 HER-2-overexpressing breast cancer cell line to study the mechanisms by which breast cancer cells escape trastuzumab-mediated growth inhibition. Both pools maintained her-2 gene amplification and protein overexpression. Resistant cells demonstrated a higher S-phase fraction by flow cytometry and a faster doubling time of 24–36 h compared with 72 h for parental cells. The cyclin-dependent kinase inhibitor p27kip1 was decreased in TR cells, and cyclin-dependent kinase 2 activity was increased. Importantly, exogenous addition of p27kip1 increased trastuzumab sensitivity. Additionally, resistant cells displayed heightened sensitivity to the proteasome inhibitor MG132, which induced p27kip1 expression. Thus, we propose that trastuzumab resistance may be associated with decreased p27kip1 levels and may be susceptible to treatments that induce p27kip1 expression.
Insulin Storage in Europe
Authors: Marco Gallo, Marco Comoglio, Alberto De Micheli, Luca Monge, Giacomo Vespasiani
Journal: Diabetes Care (2004)

The commentary by Grajower et al. (1) raised important questions concerning the storage of an opened insulin vial, prefilled syringe, or cartridge. This is a very important topic because, as the author states, due to contradictory information on this subject, most physicians are not aware of the real effectiveness of insulin once it is opened.

Individual responses from the three pharmaceutical companies that supply insulin revealed different storage indications for every type of insulin they produce, depending on the particular formulation of insulin, its method of …
von Willebrand factor (VWF) propeptide binding to VWF D′D3 domain attenuates platelet activation and adhesion
Authors: Sri R. Madabhushi, Chengwei Shang, Kannayakanahalli M. Dayananda, Kate Rittenhouse-Olson, Mary Murphy, Thomas E. Ryan, Robert R. Montgomery, Sriram Neelamegham
Journal: Blood (2012)