DIFFUSE INTRASINUSOIDAL METASTATIC CANCER OF THE LIVER
Authors: J. Chandler Smith
Journal: Annals of Internal Medicine (1961)

Case Reports1 January 1961DIFFUSE INTRASINUSOIDAL METASTATIC CANCER OF THE LIVERJ. CHANDLER SMITH, M.D.J. CHANDLER SMITH, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-54-1-104 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptCases of diffuse metastatic intrasinusoidal cancer of the liver are unique in both clinical and morphologic aspects. The clinical features include a silent and often substantial interval between the primary illness and the detection of metastasis, as well as an unusually rapid terminal course. The clinical diagnosis is often obscure, and the laboratory procedure most likely to establish the correct diagnosis has frequently not been used. The morphologic findings include an unusual distribution of metastases and an unusual location of the tumor cells within the tissues involved. In addition, the morphologic and clinical features indicate an uncommon tumor-host relationship, and...Bibliography1. Schuppel O: Zur lehre von der Histogenese des Leberkrebs. Arch. der Heilkunde 9: 387-405, 1868. Google Scholar2. Perls M: Beitrage zur Geschwultehre. Virchows Arch. f. path. Anat. 56: 437-467, 1872. CrossrefGoogle Scholar3. Litten M: Ueber einen fall von infiltrirtem Leberkrebs nebst epikritischen Bemerkungen. Virchows Arch. f. path. Anat. 80: 269-281, 1880. CrossrefGoogle Scholar4. Coupland S: Primary diffuse malignant growth in the liver in which the characters of sarcoma and carcinoma were apparently combined: rapid evolution of the disease which was of great extent, but limited to the liver. Trans. Path. Soc. London 31: 130-136, 1880. Google Scholar5. HektoenHerrick LJB: The diffuse infiltrating form of secondary melanosarcoma of the liver and its association with ascites. Amer. J. Med. Sci. 116: 255-267, 1898. CrossrefGoogle Scholar6. LeCount GR: Report of a case of diffuse infiltrating sarcoma of the liver with widely scattered metastatic tumors secondary to a sarcoma of the eye. Trans. Chicago Path. Soc. 4: 165-178, 1899-1901. Google Scholar7. Lilley CH: A case of melanotic sarcoma of the liver, secondary to a melanotic sarcoma of the eye removed by operation ten years previously. Lancet 2: 363-368, 1911. CrossrefGoogle Scholar8. French H: An unusual type of melanotic growth in the liver. Guy's Hosp. Rep. 66: 365-367, 1912. Google Scholar9. Ziegler F: Ueber Ungewohnliche Metastasenbildung in der Leber BG1 Carcinoma Mamae. Ztschr. f. Krebsforsch. 16: 427-441, 1919. CrossrefGoogle Scholar10. Sappington SW: Carcinoma of the spleen. J. A. M. A. 78: 953-955, 1922. CrossrefGoogle Scholar11. Kaufman E: Pathology for students and practitioners. Vol. 2, 1929, P. Blakiston's Son and Co., Philadelphia, p. 967. Google Scholar12. Herxheimer G in Henke, F., and Lubarsch, O., Editors: Handbuch der Speziellen Pathologischen Anatomie und Histologie 5: 956, 1930. Google Scholar13. CraciunAslanCaffee ECAL: Cirhose Atrophique Neoplasique Secondaire. Ann. d'anat. path. 8: 1089-1112, 1931. Google Scholar14. Muto K: Ein Fall von Leber-Karyinose Mit Multiplen Hamorrhagischen Infarkten Bei Primaren Magenkrebs. Gann, Tokyo 29: 251-260, 1935. Google Scholar15. Oertel H: On a peculiar vascular transportation and generalization of carcinoma without local metastasis. A contribution to the knowledge of metastatic growth. J. Path. Bact. 40: 323-334, 1935. CrossrefGoogle Scholar16. Isaji M: Ueber eine Eigentumliche form der Metastasierung eines Magenkrebses in der Leber. Wien. klin. Wchnschr. 52: 785-788, 1939. Google Scholar17. BothaLennox MCB: Repigmentation of amelanotic metastases of malignant melanoma by contact with epidermis. J. Path. Bact. 67: 99-104, 1954. CrossrefMedlineGoogle Scholar18. Watson AJ: Diffuse intra-sinusoidal metastatic carcinoma of the liver. J. Path. Bact. 69: 207-217, 1955. CrossrefMedlineGoogle Scholar19. MicolonghiPinedaStanley TEMM: Metastatic carcinomatous cirrhosis of the liver. Report of a case in which death followed hemorrhage from esophageal varices and hepatic coma. Arch. Path. 65: 56-62, 1958. Google Scholar20. Lieber MM: The rare occurrence of metastatic carcinoma in the cirrhotic liver. Amer. J. Med. Sci. 233: 145-152, 1957. CrossrefMedlineGoogle Scholar21. Willis RA: The spread of tumors in the human body. 1952, C. V. Mosby Co., St. Louis. Google Scholar22. Jarcho S: Diffusely infiltrative carcinoma. Arch. Path. 22: 674-696, 1936. Google Scholar23. WeisbergerHeinle ASRW: Study of fixed tissue sections of sternal bone marrow obtained by needle aspiration. I. Method and the morphology in various conditions. Am. J. Med. Sci. 215: 170-176, 1948. CrossrefMedlineGoogle Scholar24. LuckeBreedisWooBerwickNowell BCZPLP: Differential growth of metastatic tumors in liver and lung. Experiments with rabbit V2 carcinoma. Cancer Research 12: 734-738, 1952. MedlineGoogle Scholar25. Zeidman I: Metastasis: a review of recent advances. Cancer Res. 17: 157-162, 1957. MedlineGoogle Scholar26. Takahashi M: An experimental study of metastasis. J. Path. Bact. 20: 1-13, 1915. CrossrefGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: *Received for publication April 21, 1959.From St. Luke's Hospital, Saginaw, Michigan, and The Institute of Pathology, Western Reserve University, Cleveland, Ohio.Requests for reprints should be addressed to J. Chandler Smith, M.D., Research Associate, Pathology Section, Atomic Energy Medical Research Project, Western Reserve University, Cleveland 6, Ohio. 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A case reportKUPFFER-CELL DEPLETION IN CHRONIC LIVER DISEASE: IMPLICATIONS FOR HEPATIC CARCINOGENESISCor pulmonale due to tumour embolism derived from intrasinusoidal metastatic liver carcinoma.Case 38-1966DIFFUSE METASTASES IN BRONCHIAL CANCERJaundice, hepatomegaly and fever five years after a radical mastectomyAn unusual cause of rapidly progressive hepatic failureCase 77-1961 1 January 1961Volume 54, Issue 1Page: 104-113KeywordsCancer detection and diagnosisCellsLiverResearch laboratories ePublished: 1 December 2008 Issue Published: 1 January 1961 PDF downloadLoading ...