Effect of Low-Dose Continuous Estrogen and Progesterone Therapy with Calcium and Vitamin D on Bone in Elderly Women
Authors: Robert R. Recker, Robert P. Heaney, K. Michael Davies
Journal: Annals of Internal Medicine (2000)

Letters1 February 2000Effect of Low-Dose Continuous Estrogen and Progesterone Therapy with Calcium and Vitamin D on Bone in Elderly WomenRobert R. Recker, MD, Robert P. Heaney, MD, and K. Michael Davies, PhDRobert R. Recker, MDCreighton University; Omaha, NE 68131 (Recker)Creighton University; Omaha, NE 68131 (Heaney)Creighton University; Omaha, NE 68131 (Davies)Search for more papers by this author, Robert P. Heaney, MDCreighton University; Omaha, NE 68131 (Recker)Creighton University; Omaha, NE 68131 (Heaney)Creighton University; Omaha, NE 68131 (Davies)Search for more papers by this author, and K. Michael Davies, PhDCreighton University; Omaha, NE 68131 (Recker)Creighton University; Omaha, NE 68131 (Heaney)Creighton University; Omaha, NE 68131 (Davies)Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-132-3-200002010-00016 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail IN RESPONSE:Lafita and Garcia question the usefulness of dual-energy x-ray absorptiometry measurements of bone mineral density (BMD) in the identification of persons at risk for fracture. In point of fact, BMD is the most powerful measurable determinant of risk for fracture available today. The relative risk for fracture with each standard deviation reduction in BMD is 1.5 to 2.6 (1). Furthermore, as far as we know, antifracture efficacy has not been demonstrated for any agent in the absence of at least modest increases in BMD. Although resorption markers such as urinary pyridinolines and N-telopeptide are predictors of fracture, they ...References1. Cummings SR, Black DM, Nevitt MC, Browner W, Cauley J, Ensrud K, et al . Bone density at various sites for prediction of hip fractures. The Study of Osteoporotic Fractures Research Group. Lancet. 1993;341:72-5. CrossrefMedlineGoogle Scholar2. Lindsay R. Clinical utility of biochemical markers. Osteoporosis Int. 1998;9 Suppl 2 S29-S32. CrossrefGoogle Scholar3. Adachi JD. The correlation of bone mineral density and biochemical markers to fracture risk. Calcif Tissue Int. 1996;59:S16-S19. CrossrefMedlineGoogle Scholar4. Littell RC, Milliken GA, Stroup WW, Wolfinger RD. SAS System for Mixed Models. Cary, NC: SAS Institute, Inc; 1996. Google Scholar Author, Article, and Disclosure InformationAuthors: Robert R. Recker, MD; Robert P. Heaney, MD; K. Michael Davies, PhDAffiliations: Creighton University; Omaha, NE 68131 (Recker)Creighton University; Omaha, NE 68131 (Heaney)Creighton University; Omaha, NE 68131 (Davies) PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoThe Effect of Low-Dose Continuous Estrogen and Progesterone Therapy with Calcium and Vitamin D on Bone in Elderly Women Robert R. Recker , K. Michael Davies , Rachel M. Dowd , and Robert P. Heaney Effect of Low-Dose Continuous Estrogen and Progesterone Therapy with Calcium and Vitamin D on Bone in Elderly Women Francisco R. Lafita and Belinda Garcia Effect of Low-Dose Continuous Estrogen and Progesterone Therapy with Calcium and Vitamin D on Bone in Elderly Women Tom A. Elasy and Matthew J. Levinsky Effect of Low-Dose Continuous Estrogen and Progesterone Therapy with Calcium and Vitamin D on Bone in Elderly Women Jeffrey Brian Barnes and David T. Bess Metrics 1 February 2000Volume 132, Issue 3Page: 245KeywordsBoneBone mineral densityCalciumElderlyExcretionPhoton absorptiometryProgesteroneRelative riskStandard deviationVitamin D ePublished: 15 August 2000 Issue Published: 1 February 2000 Copyright & PermissionsCopyright © 2000 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...