tbuckley/cabot-search huggingface dataset:
Intersalt: an international study of electrolyte excretion and blood pressure. Results for 24 hour urinary sodium and potassium excretion. Intersalt Cooperative Research Group.
Authors: Gabriel Scally
Journal: BMJ (1988)

The relations between 24 hour urinary electrolyte excretion and blood pressure were studied in 10,079 men and women aged 20-59 sampled from 52 centres around the world based on a highly standardised protocol with central training of observers, a central laboratory, and extensive quality control. Relations between electrolyte excretion and blood pressure were studied in individual subjects within each centre and the results of these regression analyses pooled for all 52 centres. Relations between population median electrolyte values and population blood pressure values were also analysed across the 52 centres. Sodium excretion ranged from 0.2 mmol/24 h (Yanomamo Indians, Brazil) to 242 mmol/24 h (north China). In individual subjects (within centres) it was significantly related to blood pressure. Four centres found very low sodium excretion, low blood pressure, and little or no upward slope of blood pressure with age. Across the other 48 centres sodium was significantly related to the slope of blood pressure with age but not to median blood pressure or prevalence of high blood pressure. Potassium excretion was negatively correlated with blood pressure in individual subjects after adjustment for confounding variables. Across centres there was no consistent association. The relation of sodium to potassium ratio to blood pressure followed a pattern similar to that of sodium. Body mass index and heavy alcohol intake had strong, significant independent relations with blood pressure in individual subjects.
The many faces of type I interferon in systemic lupus erythematosus
Authors: Claudia Mauri, Madhvi Menon
Journal: Journal of Clinical Investigation (2015)

Systemic lupus erythematosus (SLE) is a multisystem autoimmune disease with a broad spectrum of clinical presentations involving multiple organ systems. An abnormal response to self-antigens is thought to drive the development of SLE; however, the factors that underlie this dysfunction are not clear. In this issue of the JCI, Li and colleagues present compelling evidence to show that type I interferons (IFNs) produced by plasmacytoid dendritic cells inhibit the clearance of apoptotic cells (ACs) by marginal zone macrophages. Specifically, type I IFNs increase the translocation of marginal zone (MZ) B cells to the follicular region of the spleen, thereby disrupting interactions between these B cells and MZ macrophages (MZMs), which in turn disrupts megakaryoblastic leukemia 1–mediated (MKL1-mediated) mechanosensing and inhibits AC phagocytosis by MZMs. The results of this study provide important insight into factors that inhibit AC clearance and promote the development of SLE.
Abstract 4011: Preprocedural Anemia is a Significant Predictor of Hospital Cost in Percutaneous Coronary Intervention
Authors: William B Hillegass, Brigitta C Brott, Reza E Ershadi, Marc W Mayhew, Silvio E Papapietro, Gregory D Chapman, Paul R Myers, Vijay K Misra
Journal: Circulation (2006)

Background: Pre-procedural anemia is associated with increased short-term and long-term morbidity and mortality in patients undergoing percutaneous coronary intervention (PCI). The incremental economic impact of pre-procedural anemia is examined.  Methods: Clinical, core angiographic, and cost data were prospectively collected on 1328 consecutive hospitalizations with PCI in 1153 patients. Variable and apportioned fixed costs were measured from an individual patient resource-use cost-accounting system. Hypothesized predictors of cost were examined.  Results: The mean pre-procedural hematocrit (Hct) was 39.0±5.4%. 27.9% of males and 25.6% of females were anemic. The mean age was 60±13 years. Females comprised 35% of the sample. Indication for PCI was acute ST-segment elevation MI in 14.7%, post-MI 18.7%, unstable angina 34.9%, stable angina 26.9%, and silent ischemia 4.3%. Diabetes was present in 36.4%, prior CABG in 12.5%, and cardiogenic shock 3.1%. In step-wise multivariate regression analysis, pre-procedural anemia was the third most powerful significant independent predictor of hospital cost including clinical, angiographic, and procedural factors. Age, gender, and renal dysfunction were not significant independent predictors of cost.  Conclusions: Pre-procedural anemia is common in patients undergoing PCI. Pre-procedural anemia is a significant independent predictor of total hospital cost in patients undergoing PCI. An incremental hospital cost of $250 was associated with each Hct point below the normal range. Strategies to improve the care of anemic patients undergoing PCI should be developed and prospectively tested.
Human T-cell leukemia virus type-1 (HTLV-1) Tax is expressed at the same level in infected cells of HTLV-1-associated myelopathy or tropical spastic paraparesis patients as in asymptomatic carriers but at a lower level in adult T-cell leukemia cells
Authors: Y Furukawa, M Osame, R Kubota, M Tara, M Yoshida
Journal: Blood (1995)
Blaschkoid distribution of cylindromas in a germline CYLD mutation carrier
Authors: M. Furuichi, T. Makino, T. Yamakoshi, K. Matsui, T. Shimizu
Journal: British Journal of Dermatology (2012)

Journal Article Blaschkoid distribution of cylindromas in a germline CYLD mutation carrier Get access M. Furuichi, M. Furuichi Department of Dermatology, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, Sugitani 2630, Toyama 930‐0194, Japan Search for other works by this author on: Oxford Academic Google Scholar T. Makino, T. Makino Department of Dermatology, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, Sugitani 2630, Toyama 930‐0194, Japan Teruhiko Makino. E‐mail: tmakino@med.u‐toyama.ac.jp Search for other works by this author on: Oxford Academic Google Scholar T. Yamakoshi, T. Yamakoshi Department of Dermatology, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, Sugitani 2630, Toyama 930‐0194, Japan Search for other works by this author on: Oxford Academic Google Scholar K. Matsui, K. Matsui Department of Dermatology, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, Sugitani 2630, Toyama 930‐0194, Japan Search for other works by this author on: Oxford Academic Google Scholar T. Shimizu T. Shimizu Department of Dermatology, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, Sugitani 2630, Toyama 930‐0194, Japan Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 166, Issue 6, 1 June 2012, Pages 1376–1378, https://doi.org/10.1111/j.1365-2133.2012.10869.x Published: 01 June 2012
Immunocompetence of Patients with Protein-Calorie Malnutrition
Authors: DENNIS K. LAW
Journal: Annals of Internal Medicine (1973)

Both the thymus (T)- and bone marrow (B)-dependent immune systems were evaluated in 18 adults with protein-calorie malnutrition and in 12 control patients. Seven of the 18 malnourished patients received intravenous hyperalimentation for 18 days, and their immune competence was then compared with that before treatment. Serum immunoglobulin levels were unaffected by the malnutrition or the treatment. The T system, assessed by either delayed skin reactivity to primary and secondary antigens or in-vitro lymphocyte responses to phytohemagglutinin, was impaired in patients with protein-calorie malnutrition. The B system, evaluated by measurement of early serum IgM antibody response to keyhole limpet hemocyanin was also impaired in these patients. Intravenous hyperalimentation resulted in improvement of delayed skin reactivity and lymphocyte responses to phytomitogens. Apparently, both the T and B systems are impaired in adults with moderate protein calorie malnutrition, and nutritional repletion will improve their immunocompetence.
350. Gene Transfer of Modified Idiotype into Dendritic Cells for Immunotherapy of Non-Hodgkin Lymphomas
Authors: Sara Muraro, Attilio Bondanza, Matteo Bellone, Philip Greenberg, Chiara Bonini
Journal: Molecular Therapy (2004)

The majority of B cell non-Hodgkin Lymphomas (NHL) are characterized by the clonal expansion of a single B cell expressing a tumor-specific antigen, the idiotype (Id). Studies in animal models and clinical trials have shown that the therapeutic efficacy of Id-based vaccines correlates with cellular immune responses, although humoral responses have been better characterized. This study exploits a molecular approach to modify and transfer the unique Id of the murine 38C13 lymphoma into dendritic cells (DCs) for simultaneous stimulation of CD8+ and CD4+ tumor reactive T lymphocytes. We first created chimeric constructs coding for Id fused with the targeting signal of the lysosomal associated membrane protein 1 (LAMP1), able to enhance antigen presentation in the context of MHC class II. We constructed recombinant vaccinia viruses (rVV) coding for Id-LAMP1 to express the chimeric gene into DCs, obtaining a 40–50% infection efficiency. Since rVV interferes with maturation of DCs, thus limiting their immunostimulatory functions, we infected previously matured DC with rVVs, thus generating fully mature DCs expressing the antigen and co-stimulatory molecules, and producing IL-12. We then immunized mice with DCs infected with an irrelevant rVV, rVV-Id or rVV-Id-LAMP1. We showed that a single vaccination elicits both a CD4+ and a CD8+ immune responses specific for 38C13. Both CD4+ and CD8+ responses were significantly more robust in animals vaccinated with DC infected with rVV-Id-LAMP1 than in animals vaccinated with DC infected with rVV-Id. Furthermore, 73% of mice immunized with DCs infected with rVV-Id-LAMP1 (and only 36% of animals immunized with DCs infected with rVV-Id) were protected from tumor challenge, while all mice immunized with DCs infected with an irrelevant rVV died of lymphoma. The majority of protected mice rejected the tumor after tumor rechallenge. The curative potential of Id-specific T cells was validated in adoptive transfer experiments. B-depleted Id-specific T cells cured the majority (up to 90%) of tumor bearing mice. To facilitate translation to the clinical setting, we repeated the experiments by using DCs transfected with RNA coding for Id-LAMP1. Despite a lower gene transfer efficiency, the ability of RNA-transfected DC to elicit Id-specific CD8+ and CD4+ responses was higher than what observed with rVV. 90% of the animals vaccinated with DCs transfected with RNA coding for Id-LAMP1 survived tumor free for more than sixty days. These results indicate that LAMP1, once fused with the Id, enhance the CD8+ and CD4+ cellular responses to Id and that these responses are curative for B-cell lymphomas.
Abstract 11693: Identifying Clinically Inaccurate Conversions From ICD-9 to ICD-10 in Cardiology Clinical Practice
Authors: Satish J Chacko, Robert Danziger, Andrew Boyd
Journal: Circulation (2014)

Introduction: For the past 30 years, the ICD-9 clinical code set has been used to assign diagnoses to clinical encounters in the United States. On October 1, 2015 reimbursement will be tied to ICD-10, a code set which will increase code volume fivefold and increase cardiology specific codes 2.6 fold. This complex transition will affect billing, data collection, and inventory management among others. The government has proposed a General Equivalence Mapping from ICD-9 to ICD-10 but in practice this tool has been found to have limited clinical relevance. To better characterize the consequences of this transition and to predict inaccurate code pairings, we evaluated ICD-9 codes from Illinois cardiology clinics using an online conversion tool. Methods: From the 2010 Illinois Medicaid database, 681 primary ICD-9 codes were used in cardiology clinics. 180 of these at high risk for information loss were identified and evaluated. These codes were visually mapped using the Lussier online conversion tool and were e...
936. Phage-Selected Motifs Internalize Via Multiple Endocytic Pathways and Facilitate Gene Delivery
Authors: Zhengrong Hao, Yan Huang, Dinggang Liu, Jun Yu, Bill Sessa, Frank J. Giordano
Journal: Molecular Therapy (2004)

Top of pageAbstract
The ability to direct internalization of macromolecules into cells or across endothelial barriers efficiently has tremendous therapeutic implications. Several internalization motifs (IM) that exist in nature have been defined and exploited, including the third -helix of the Drosophila Antennapedia homeodomain and the HIV TAT protein. To investigate the general properties required for protein-based macromolecule internalization we constructed and performed peptide phage display (PPD) with T7 bacteriophage random 7-mer peptide libraries. Functional biopanning with the T7 libraries was performed on microvascular endothelial cells (EC) to select peptide motifs that could internalize phage. The titer of internalized phage increased through sequential rounds of biopanning and resulted in selection of phage expressing IM with a finite shared sequence relationship between charged, polar, and hydrophobic amino acids. Selected IM were synthesized as rhodamine-labeled free peptides and their internalization properties were investigated in EC. Internalization of IM was inhibited at 4 degrees, suggesting an energy dependent mechanism of internalization. Confocal data showed that the IM was internalized via at least two different endocytic pathways: clathrin-coated pits and lipid rafts. Treatment with inhibitors of clathrin-mediated and lipid raft endocytosis inhibited uptake of IM, consistent with the result from confocal study. Further, in vitro and in vivo studies indicated that precomplexing of adenovirus with the IM facilitated the degree of viral transduction into endothelial cells and across endothelial barriers. These data suggest that relatively short peptide motifs are capable of directing macromolecules to diverse internalization pathways. It may be possible to exploit these characteristics for targeted delivery of therapeutic macromolecules to cells and tissues, and potentially to develop more efficient methods of gene transfer.
HYPERTENSION CAUSED BY UNILATERAL KIDNEY DISEASE (A FOLLOW-UP REPORT)
Authors: J S SWEENEY, J M PACE
Journal: Annals of Internal Medicine (1948)

Case Reports1 August 1948HYPERTENSION CAUSED BY UNILATERAL KIDNEY DISEASE (A FOLLOW-UP REPORT)J. SHIRLEY SWEENEY, M.D., Sc.D., F.A.C.P., JOHN M. PACE, M.D., F.A.C.S.J. SHIRLEY SWEENEY, M.D., Sc.D., F.A.C.P., JOHN M. PACE, M.D., F.A.C.S.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-29-2-370 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptIn the December 1943 edition of this Journal, we reported a case of hypertension caused by unilateral kidney disease.1The patient (M. J. M.) was at that time unmarried, aged 21, and consulted one of us (J. S. S.) on May 3, 1941. She was referred by her family physician because of high blood pressure. Her family history was entirely negative. Her menstrual history, likewise, was perfectly normal. The only illness that she had had during childhood was measles. She stated that she had had some sort of kidney trouble, the nature of which was not clear; however, she remembered...Bibliography1. SWEENEYPACE JSJM: Hypertension caused by unilateral kidney disease, Ann. Int. Med., 1943, xix, 1013-1017. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Dallas, Texas*Received for publication April 18, 1947.†Medical Director, The Sweeney Diabetic Foundation, For the Study and Treatment of Diabetes and Allied Metabolic Disorders, Gainesville, Texas. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byIntrinsic Blood Pressure 1 August 1948Volume 29, Issue 2Page: 370-374KeywordsHypertensionKidneysMeaslesMetabolic disordersPrimary hypertensionRenal diseases ePublished: 1 December 2008 Issue Published: 1 August 1948 PDF downloadLoading ...
Abstract 796: Histone deacetylase inhibitors restore toxic BH3 domain protein expression in anoikis-resistant mammary and brain cancer stem cells, thereby enhancing the response to anti-ERBB1/ERBB2 therapy
Authors: Nichola A. Cruickshanks, Hossein A. Hamed, Larry A. Booth, Seyedmehrad Tavallai, G B. Sajithlal, Steven Grant, Andrew Poklepovic, Paul Dent
Journal: Cancer Research (2014)

Abstract Detachment of cells from the extracellular matrix (ECM) results in a form of cell death referred to as anoikis. Anoikis resistance (AR), frequently acquired by malignant cells, is required for tumor metastases. The present study focused on identifying the mechanisms by which drug sensitivity is restored in previously resistant AR breast cancer cells. AR breast cancer cells display reduced expression of the toxic BH3 domain proteins BAX, BAK, NOXA and PUMA. In contrast, expression of the protective BCL-2 family proteins BCL-XL and MCL-1 was increased. It has previously been noted that AR cells display resistance to several currently available anti-tumor cell therapies, including a combinational approach with Lapatinib (ERBB1/2 inhibitor) and Obatoclax (MCL-1 inhibitor, exhibiting reduced autophagic flux, despite similarly exhibiting increased levels of LC3II processing. Knockdown of MCL-1 and BCL-XL in AR cells resulted in apoptosis to a greater extent than in their wild-type counterparts. Pre-treatment of AR cells with Valproate (histone deacetylase inhibitor (HDACIs)); for 24hrs increased the levels of toxic BH3 domain proteins whilst simultaneously reducing levels of MCL-1 and re-sensitising AR cells to therapy-mediated cell death. In vivo, pre-treatment of AR breast tumors in the brain with valproate restored chemo-sensitivity and prolonged animal survival. These data argue that pre-treatment with HDACIs may provide a mechanism to enhance the anti-tumor effect of chemotherapy in AR breast cancer cells. Citation Format: Nichola A. Cruickshanks, Hossein A. Hamed, Larry A. Booth, Seyedmehrad Tavallai, G B. Sajithlal, Steven Grant, Andrew Poklepovic, Paul Dent. Histone deacetylase inhibitors restore toxic BH3 domain protein expression in anoikis-resistant mammary and brain cancer stem cells, thereby enhancing the response to anti-ERBB1/ERBB2 therapy. [abstract]. In: Proceedings of the 105th Annual Meeting of the American Association for Cancer Research; 2014 Apr 5-9; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2014;74(19 Suppl):Abstract nr 796. doi:10.1158/1538-7445.AM2014-796
Cytosine arabinoside with daunorubicin or adriamycin for therapy of acute myelocytic leukemia: a CALGB study
Authors: J Yates, O Glidewell, P Wiernik, MR Cooper, D Steinberg, H Dosik, R Levy, C Hoagland, P Henry, A Gottlieb, C Cornell, J Berenberg, JL Hutchison, P Raich, N Nissen, RR Ellison, R Frelick, GW James, G Falkson, RT Silver, F Haurani, M Green, E Henderson, L Leone, JF Holland
Journal: Blood (1982)
Use of an Antibacterial Powder Spray to Prevent Post Prostatectomy Urinary Infection
Authors: M J Lynch, J P A MacDermott, D J Byrne, P A Hamilton Stewart
Journal: Journal of the Royal Society of Medicine (1991)

To prevent ascending urinary infection in patients following transurethral prostatectomy, we have studied the use of a topical antibacterial agent applied to the groin and external genitalia. A prospective randomized controlled trial was conducted, with 50 patients being treated by daily application of a 2% polynoxylin powder, and 50 patients acting as untreated controls. Patient age and duration of catheterization were similar in the treated and untreated groups. No significant benefit was seen in the treated cohort (P greater than 0.05) in terms of reduction in postoperative urinary infection.
Complex karyotype in a polycythemia vera patient with a novel SETD1B/GTF2H3 fusion gene
Authors: Clelia Tiziana Storlazzi, Lisa Pieri, Chiara Paoli, Giulia Daniele, Terra Lasho, Ayalew Tefferi, Alessandro M. Vannucchi
Journal: American Journal of Hematology (2014)

The patient had been diagnosed with polycythemia vera (PV) in 1999, at the age of 61, according to the criteria of the Polycythemia Vera Study Group (PVSG) on the basis of the increased red cell mass by isotope determination, normal oxygen saturation, low plasma erythropoietin level, presence of endogenous erythroid colonies (EEC), and splenomegaly. Histopathology of bone marrow biopsy was also consistent with polycythemia vera with no evidence of increased reticulin fibrosis. A karyotype analysis was not performed at that time. He had been treated initially with phlebotomies and then with hydroxyurea with the aim to obtain a better control of hematocrit; he was under low‐dose aspirin. In 2009, 10 years after the diagnosis, while the patient was still being treated with hydroxyurea and phlebotomies, he noticed worsening of general conditions and fatigue, and the appearance of night sweats; he also reported that his spleen volume had increased rapidly in the past few months. He complained of severe pruritus especially after (but not limited to) a shower. He was referred to our center for further evaluation. At presentation, his blood counts were as follows: hemoglobin 157 g/L, hematocrit 54.7%, leukocytes 13.1 × 10 9 /L, platelets 238 × 10 9 /L, LDH 856 U/L (normal upper limit, 250 U/L). Blood film examination showed neutrophilia (8.9 × 10 9 /L) but immature myeloid cells and nucleated erythroblasts were absent. The spleen was 14 cm below the left costal margin, the liver was at 4 cm below the right costal margin. He was found to harbor the JAK2 V617F mutation with an allele burden of 85% and the circulating CD34 + cell count was 14 × 10 6 /L. A bone marrow biopsy showed the presence of hyperplasia of myeloid and erythroid lineages, increased number of scattered megakarocytes without overt morphologic abnormalities; reticulin fibrosis was grade 1 according to the European classification. On these basis, we considered the patient as presenting the features of PV according to the 2008 WHO classification of myeloid neoplasms associated with grade 1 reticulin fibrosis. Am. J. Hematol. 89:438–442, 2014. © 2014 Wiley Periodicals, Inc.