tbuckley/cabot-search huggingface dataset:
Meta-Analysis and Bouillabaisse
Authors: William M. Tierney
Journal: Annals of Internal Medicine (1996)

Letters15 September 1996Meta-Analysis and BouillabaisseWilliam M. Tierney, MDWilliam M. Tierney, MDIndiana University School of Medicine, Indianapolis, IN 46202Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-125-6-199609150-00030 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:I read with interest the recent editorial by Dr. Messerli [1]. As both a health services researcher-clinical epidemiologist and a practicing general internist, I have found the controversy about calcium channel blockers to be enlightening and frustrating. I strongly agree with Dr. Messerli that controlled studies documenting the safety and efficacy of calcium channel blockers are desperately needed. (It is interesting that such trials have not been done, and yet billions of dollars are spent each year prescribing and marketing these drugs.)I do, however, disagree with two of his other statements. Messerli correctly states that case–control ...References1. Messerli FH. Case-control study, meta-analysis, and bouillabaisse: putting the calcium antagonist scare into context. Ann Intern Med. 1995; 11:888-9. Google Scholar2. Psaty BM, Heckbert SR, Koepsell TD, Siscovick DS, Raghunathan TE, Weiss NS, et al. The risk of myocardial infarction associated with antihypertensive drug therapies. JAMA. 1995; 274:620-5. Google Scholar3. Joint National Committee on Detection, Evaluation, and Treatment of High Blood Pressure. The Fifth Report of the Joint National Committee on Detection, Evaluation, and Treatment of High Blood Pressure (JNC V). Arch Intern Med. 1993; 153:154-83. Google Scholar Author, Article, and Disclosure InformationAffiliations: Indiana University School of Medicine, Indianapolis, IN 46202 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByStress echocardiography: the long and winding road from meta-analysis to bedsideConflict of Interest in the Debate over Calcium-Channel Antagonists 15 September 1996Volume 125, Issue 6Page: 519KeywordsCalcium channel blockerDrug safetyDrugsEpidemiologyHypertensionMedical servicesMyocardial infarctionPrimary hypertensionSafety studiesTreatment guidelines Issue Published: 15 September 1996 CopyrightCopyright © 1996 by American College of Physicians. All Rights Reserved.PDF DownloadLoading ...
High Court overturns GMC's decision to strike off plastic surgeon
Authors: Clare Dyer
Journal: BMJ (2005)

A “uniquely talented” plastic surgeon who was erased from the medical register by the General Medical Council earlier this year for having a sexual relationship with a patient won a High Court ruling last week. The court quashed the decision and substituted a suspension of 12 months.

The judgment in the case of Henk Giele spells out that the correct approach in such cases is not to consider erasure the rule, in the absence of exceptional circumstances.

Mr Justice Collins said that the advice given to the GMC panel by its legal assessor had been erroneous. The assessor had advised the panel that sexual misconduct tended to attract erasure but that …
Donor activating KIR3DS1 is associated with decreased acute GVHD in unrelated allogeneic hematopoietic stem cell transplantation
Authors: Jeffrey M. Venstrom, Ted A. Gooley, Stephen Spellman, James Pring, Mari Malkki, Bo Dupont, Effie Petersdorf, Katharine C. Hsu
Journal: Blood (2010)
Anesthesia Simulator Consultant: Improve Your Response to Anesthetic Emergencies
Authors: Tod B. Sloan
Journal: JAMA (1995)

<i>Anesthesia Simulator Consultant</i>version 2.0 represents a major enhancement of the first version of this simulation software for the management of anesthesia during surgery. Its value in providing "experience" in handling uncommon problems is enhanced by expansion of the caseload to 80 different clinical scenarios. New in version 2.0 are pediatric and obstetric patients and outpatients; still included are adult general surgery, neurosurgery, and cardiac surgery cases. Anesthesia management techniques have been expanded to include regional blocks (spinal, epidural, axillary, Bier, interscalene, retrobulbar, and sciatic-femoral). Since one goal of the simulation is to allow the user to experience complications and management problems, the program allows the choice of deliberate or random problems with the first four cases only. The remaining cases present either complicated management problems or fixed complications. Dozens of critical events are present, providing practice opportunities with myocardial ischemia, cardiac arrest, malignant hyperthermia, bronchospasm, anaphylactic reactions, and many
Kidney transplantation in an elite HIV controller: Limited impact of immunosuppressive therapy on viro-immunological status
Authors: Olivier Lambotte, Camille Lecuroux, Asier Saez-Cirion, Christelle Barbet, So Youn Shin, Faroudy Boufassa, Frédéric Bastides, Yvon Lebranchu
Journal: Journal of Infection (2012)
Urethral Syndrome?-Reply
Authors: Robert Zufall
Journal: JAMA (1963)

Dr. Zufall replies in the letter which follows. Dr. Rinker expresses the opinion of many urologists, who feel that the symptoms of which these women complain must be related to the various things found in their bladder outlets. Good response to local treatment naturally strengthens these impressions. I have been unable to establish any statistical basis for these ideas. In my experience there has been no correlation between symptoms, cystoscopic findings, and response to one or another treatment. My experience would suggest that Dr. Rinker's grateful patients may have been helped as much by his being a sympathetic and concerned physician as by his treatment of the trigones. It has been called to my attention that urethral meatotomy has been used for years in the treatment of this condition and I shall certainly try it. In the July, 1963, issue of the<i>Journal of Urology</i>, Dr. Streitz notes that the
CD8+ T Cell Recognition of Epitopes Within the Capsid of Adeno-associated Virus 8–based Gene Transfer Vectors Depends on Vectors’ Genome
Authors: Te-Lang Wu, Hua Li, Susan M Faust, Emily Chi, Shangzhen Zhou, Fraser Wright, Katherine A High, Hildegund CJ Ertl
Journal: Molecular Therapy (2013)

Self-complementary adeno-associated viral (AAV) vectors expressing human factor IX (hF.IX) have achieved transient or sustained correction of hemophilia B in human volunteers. High doses of AAV2 or AAV8 vectors delivered to the liver caused in several patients an increase in transaminases accompanied by a rise in AAV capsid-specific T cells and a decrease in circulating hF.IX levels suggesting immune-mediated destruction of vector-transduced cells. Kinetics of these adverse events differed in patients receiving AAV2 or AAV8 vectors causing rise in transaminases at 3 versus 8 weeks after vector injection, respectively. To test if CD8+ T cells to AAV8 vectors, which are similar to AAV2 vectors are fully-gutted vectors and thereby fail to encode structural viral proteins, could cause damage at this late time point, we tested in a series of mouse studies how long major histocompatibility (MHC) class I epitopes within AAV8 capsid can be presented to CD8+ T cells. Our results clearly show that depending on the vectors' genome, CD8+ T cells can detect such epitopes on AAV8's capsid for up to 6 months indicating that the capsid of AAV8 degrades slowly in mice.
A CASE OF BENIGN MELANOSIS.
Authors: J. CLARK STEWART
Journal: JAMA (1907)

Melanin occurs normally in man and the animals in the chorioid, hair and skin, also in some animals in spe- cialized organs, as the ink bags of the cuttle fish.It occurs as the coloring matter of pigmented sarcoma in man and animals, and also in the latter as the result of certain parasites.Its origin seems still in doubt, but most authorities agree that it is not a direct derivative from blood pigment, but the product formed by the metabolic activity of specialized cells.It is composed of nitrogen, hydro- gen and carbon in the proportions of nitrogen one part to five of each of the others, with sulphur varying up to 10 per cent.and iron present sometimes in small amounts.Melanuria is clinically of two distinct types: First, one in which the urine is black or very dark colored when passed and contains melanin by chemical tests; second, one in which the urine is not abnormal in color when passed, but on standing and oxidization becomes black or dark colored.Melanotic urine occurs under several
Loss of <i>LRIG1</i> Locus Increases Risk of Early and Late Relapse of Stage I/II Breast Cancer
Authors: Patricia A. Thompson, Ingrid Ljuslinder, Spyros Tsavachidis, Abenaa Brewster, Aysegul Sahin, Håkan Hedman, Roger Henriksson, Melissa L. Bondy, Beatrice S. Melin
Journal: Cancer Research (2014)

Gains and losses at chromosome 3p12-21 are common in breast tumors and associated with patient outcomes. We hypothesized that the LRIG1 gene at 3p14.1, whose product functions in ErbB-family member degradation, is a critical tumor modifier at this locus. We analyzed 971 stage I/II breast tumors using Affymetrix Oncoscan molecular inversion probe arrays that include 12 probes located within LRIG1. Copy number results were validated against gene expression data available in the public database. By partitioning the LRIG1 probes nearest exon 12/13, we confirm a breakpoint in the gene and show that gains and losses in the subregions differ by tumor and patient characteristics including race/ethnicity. In analyses adjusted for known prognostic factors, loss of LRIG1 was independently associated with risk of any relapse (HR, 1.90; 95% CI, 1.32-2.73), relapse≥5 years (HR, 2.39; 95% CI, 1.31-4.36), and death (HR, 1.55; 95% CI, 1.11-2.16). Analyses of copy number across chromosome 3, as well as expression data from pooled, publicly available datasets, corroborated the hypothesis of an elevated and persistent risk among cases with loss of or low LRIG1. We concluded that loss/low expression of LRIG1 is an independent risk factor for breast cancer metastasis and death in stage I/II patients. Increased hazard in patients with loss/low LRIG1 persists years after diagnosis, suggesting that LRIG1 is acting as a critical suppressor of tumor metastasis and is an early clinical indicator of risk for late recurrences in otherwise low-risk patients.
GW25-e3219 Urotensin II induces endothelial-mesenchymal transition of cardiac microvascular endothelial cells via Smad2/3 activation
Authors: Zi-Han Chen, Qian-Qian Wang, Wei-Zhao Lin, Bao-Jun Yang, Xiao-Ying Li, Yong-Gang Zhang
Journal: Journal of the American College of Cardiology (2014)
Abstract 173: Targeted killing of cancer stem-like cells by a novel analogue of curcumin
Authors: Bin Bao, Shadan Ali, Dejuan Kong, Sanila H. Sarkar, Zhiwei Wang, Sanjeev Banerjee, Amro Aboukameel, Subhash Padhye, Philip A. Philp, Fazlul H. Sarkar
Journal: Cancer Research (2011)

Abstract The existence of cancer stem cells (CSCs) or cancer stem-like cells in a tumor mass is believed to be responsible for tumor recurrence because of their intrinsic and extrinsic drug-resistance characteristics. Therefore, targeted killing of CSCs would be a newer strategy for the prevention of tumor recurrence and/or treatment by overcoming drug-resistance. We have developed a novel synthetic compound-CDF, which showed greater bioavailability in animal tissues such as pancreas, and also induced cell growth inhibition and apoptosis, which was mediated by inactivation of NF-κB, COX-2, and VEGF in pancreatic cancer (PC) cells. In the current study we showed, for the first time, that CDF could significantly inhibit the sphere-forming ability (pancreatospheres) of PC cells consistent with increased disintegration of pancreatospheres, which was associated with attenuation of CSC markers (CD44 and EpCAM), especially in gemcitabine-resistant (MIAPaCa-2) PC cells containing high proportion of CSCs consistent with increased miR-21 and decreased miR-200. Moreover, CDF treatment showed increased protein levels of phospho-β-catenin, and decreased levels of Wnt3a, β-catenin, LEF1, and CD44. In a xenograft mouse model of human PC, CDF treatment significantly inhibited tumor growth, which was associated with decreased NF-κB DNA binding activity, COX-2, Wnt3a, and miR-21 expression, and increased PTEN and miR-200 expression in tumor remnants. These results strongly suggest that the anti-tumor activity of CDF is associated with inhibition of CSC function via down-regulation of CSC-associated signaling pathways. Therefore, CDF could be useful for the prevention of tumor recurrence and/or treatment of PC with better treatment outcome in the future. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 102nd Annual Meeting of the American Association for Cancer Research; 2011 Apr 2-6; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2011;71(8 Suppl):Abstract nr 173. doi:10.1158/1538-7445.AM2011-173
Lord Mayor Treloar Hospital, Alton
Authors: J A Lunn
Journal: BMJ (1978)

Self-examination of the breasts SIR,-The technique usually described for carrying out self-examination of the breasts is repeated from pamphlet to pamphlet without question, and the description in the BMJ (5 August, p 413) is no exception.It would seem that no authors have actually tried to carry out the manoeuvre that they advocate, for they would find that it is not very practicable.To expect a woman to examine the medial half of her breast using the flat of the ipsilateral hand demands a combination of gymnastic skill and hyperextension of the metacarpophalangeal joints not usually found outside a ballet school.Self-examination of the breast should be carried out in the same way that a doctor would do a clinical examination of the breasts.The flat of the right hand is drawn right across the left breast from left to right.Starting at the top of the breast this is repeated at lower levels until the whole breast has been palpated.The left hand is then used to examine the right breast in a similar way.
Prognosis of Pneumocystis carinii Pneumonia in the Acquired Immunodeficiency Syndrome
Authors: Mark J. Rosen, Tony W. Y. Tow, Ming T. Chuang, Alvin S. Teirstein
Journal: Annals of Internal Medicine (1984)

Letters and Corrections1 August 1984Prognosis of Pneumocystis carinii Pneumonia in the Acquired Immunodeficiency SyndromeMARK J. ROSEN, M.D., TONY W. Y. TOW, M.D., MING T. CHUANG, M.D., ALVIN S. TEIRSTEIN, M.D.MARK J. ROSEN, M.D.Search for more papers by this author, TONY W. Y. TOW, M.D.Search for more papers by this author, MING T. CHUANG, M.D.Search for more papers by this author, ALVIN S. TEIRSTEIN, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-101-2-276_1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: The article by Kovacs and associates (1) examined several factors that predict a favorable prognosis in patients with the acquired immunodeficiency syndrome and Pneumocystis carinii pneumonia. One additional indicator of a favorable prognosis in these patients is a normal chest roentgenogram at the time of diagnosis. Over a 24-month period, we encountered 29 patients with both the acquired immunodeficiency syndrome and P. carinii pneumonia at our institution. Eight of these patients had a normal chest roentgenogram as reported by hospital radiologists and confirmed by subsequent review. All eight patients were successfully treated and discharged from the hospital....Reference1. KOVACSHIEMENZMACHER JJA. Pneumocystis carinii pneumonia: a comparison between patients with the acquired immunodeficiency syndrome and patients with other immunodeficiencies. Ann Intern Med. 1984;100:663-71. LinkGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byThe management of HIV-related illness in the emergency departmentFacteurs initiaux de gravite de la pneumopathie a Pneumocystis carinii au cours de l'infection HIVEvaluating institutional performance in AIDS-associated Pneumocystis carinii pneumonia: A risk adjustment approachCORTICOSTEROIDS AS ADJUNCTIVE THERAPY IN TREATMENT OF PNEUMOCYSTIS CARINII PNEUMONIA IN PATIENTS WITH ACQUIRED IMMUNODEFICIENCY SYNDROMEPneumocystis carinii pneumonia. 1 August 1984Volume 101, Issue 2Page: 276-276KeywordsAIDSPneumocystis carinii pneumoniaPneumoniaRadiologistsThorax Issue Published: 1 August 1984 PDF downloadLoading ...
Now Hear This, Slacker Gome Doctors: Anal-Retentive Gunner Shoots Down Pass/Fail-Reply
Authors: Michael D. Cantor
Journal: JAMA (1991)

<h3>In Reply.—</h3> Mr Korzeniowski raises many of the objections to a pass/fail system of scoring for the NBME tests and soon-to-be-implemented USMLE that were debated and rejected by the American Medical Association House of Delegates at its interim meeting in Orlando, Fla, last December.<sup>1</sup>The American Medical Association, the Organization of Student Representatives of the American Association of Medical Colleges, the American Medical Women's Association, and the American Medical Students' Association are unanimous in their commitment to the concept of pass/fail reporting of licensure examination scores. Being a good physician requires more than doing well on standardized examinations; high scores on a licensure examination should not be misused to screen out potentially excellent physicians. Mr Korzeniowski correctly observes that standardized tests are an important part of the selection process for colleges and medical schools, but fails to recognize that the NBME tests and the USMLE are not designed as
LIVING SUTURES FOR HERNIOTOMY
Authors: J. H. Shephard
Journal: JAMA (1924)

<h3>To the Editor:</h3> —InThe Journal, February 23, appears an article by Dr. Frank Adair on living sutures for inguinal herniotomy. These "rediscoveries" are causing a useless increase in the volume of medical literature. Dr. L. L. McArthur of Chicago has for years made use of the aponeurosis of the external oblique muscle in the repair of hernia. His technic is amply illustrated in Volume 2 of Operative Surgery by Joseph D. Bryant, published in 1906. [The letter of Dr. Shephard was referred to Dr. Adair, whose reply follows:]
A Textbook of Surgical Pathology
Authors: Brock E. Brush
Journal: JAMA (1961)

This is the eighth edition of an excellent textbook which has been popular with medical students and surgeons since it was originally published in 1931. The material in this book, as in the previous editions, begins with the basic conditions of injury and repair of tissue, then goes on to various types of infections, and comes finally to the latest information about tumors. Individual chapters are written about diseases of the various structures and organs of the body, and all of the surgical conditions commonly encountered are included. This greatly enhances the book's value as a reference work as well as a textbook. Conditions of the greatest importance and value for the surgeon to know have been emphasized, along with the relevant features seen in microscopic examination of tissues and in postmortem examinations. This edition has been brought completely up to date, an undertaking which has resulted in several changes
Increased Matrix Metalloproteinase-9 Predicts Poor Wound Healing in Diabetic Foot Ulcers
Authors: Yu Liu, Danqing Min, Thyra Bolton, Vanessa Nubé, Stephen M. Twigg, Dennis K. Yue, Susan V. McLennan
Journal: Diabetes Care (2009)

We thank the authors for their comment (1) on our study (2) and we agree that the pathophysiology of diabetic foot ulcers is complex and not well understood. We recognize that we are not the first to establish a potential role for matrix metalloproteinase-9 (MMP-9) in chronic wound healing. However, we report that its measurement …
The Use of Antibiotics and Vasodilators in Atrophic Rhinitis (Ozena)
Authors: H. J. Sternstein
Journal: New England Journal of Medicine (1951)

THE purpose of this report is to present a new method for the treatment of atrophic rhinitis with ozena, by combining the local use of streptomycin and other antibiotics with vasodilators. Various investigators in the past1 2 3 have studied the local effects of vasodilator drugs in this disease. In 1938, Hnik4 reported that histamine ionization resulted in reduction or elimination of the offensive odor and crusts and increased vascularization of the nasal mucosa. Recently,5 , 6 experiments with streptomycin in local and parenteral form have produced a striking disappearance of odor and the klebsiella organisms (Friedländer's bacillus), but a less appreciable effect on . . .
Teenage pregnancy is not a public health problem
Authors: D. Lawlor, M. Shaw, S. Johns
Journal: BMJ (2001)

EDITOR—We agree with Smith and Pell's interpretation of their own and others' results that first teenage pregnancies are not associated with adverse outcomes, but we disagree with their conclusion that the associations they found between second teenage pregnancy and risk of preterm delivery and stillbirth indicate causation.1 The most likely explanation is a combination of inadequate control for socioeconomic position, which the authors concede, and differences in the interval between pregnancies among teenage compared with older mothers.

Differences in pregnancy spacing cannot be …
ACCESSORY MUSCLE MOVEMENTS IN DELTOID PARALYSIS
Authors: LEWIS J. POLLOCK
Journal: JAMA (1922)

The preservation of certain movements, the loss of which is supposed to result from injury to particular nerves, has been observed for many years. Sherren<sup>1</sup>called attention to the fact that Swan, in 1834, was astonished at observing how much a rabbit could move its leg after experimental section of its sciatic nerve. Later Letíevant<sup>2</sup>studied this phenomenon and termed it supplementary motility. Since that time, numerous investigators have observed its presence in various peripheral nerve lesions. Supplementary motility producing abduction of the arm in cases of complete paralysis of the deltoid muscle has been observed in a number of cases. Few reports dealing specifically with supplementary motility in deltoid paralysis are found in English literature, and mention of it is often included in contributions dealing with broader subjects. It therefore seems that it is of value to confirm and emphasize this observation. The first case reported was
Successful Carotid Endarterectomy For Cerebrovascular Insufficiency
Authors: Michael E. DeBakey
Journal: JAMA (1975)

This is believed to be the first successful case of thromboendarterectomy for cerebrovascular insufficiency caused by atherosclerotic occlusion of the carotid artery, as well as the longest follow-up study. At the time of the patient's death from coronary occlusion, 19 years after operation, he had no cerebrovascular symptoms, and there was clinical evidence of maintenance of the restored circulation in the carotid artery.
A CASE OF COMBINED GASTRIC AND AURAL VERTIGO, WITH A DISCUSSION OF THE PATHOLOGY OF SUCH CASES.
Authors: G. W. McCASKEY
Journal: JAMA (1901)

The pathology of the symptom known as vertigo is obscure in a great many cases. It seems quite clear that in some, and that a rather large number, it is the direct or indirect result of general causes acting on the nervous or vascular mechanism. As a temporary phenomenon it is often present in states of general debility, from whatever causes arising, especially on assuming, or suddenly relaxing from, constrained positions, or making sudden movements of the head. To a variable extent it forms a feature of the various acute and chronic intoxications both heterogenetic and autogenetic. It is a very frequent symptom of organic brain disease. Mendel says that every focus of organic brain disease will necessarily influence the cerebral circulation, and may consequently be associated with vertigo. This is especially true where the lesion is situated in a posterior fossa. The present tendency on the part of some