tbuckley/cabot-search huggingface dataset:
Serum Creatine Kinase Screening for Susceptibility to Malignant Hyperthermia-Reply
Authors: R. T. Paasuke
Journal: JAMA (1986)

<h3>In Reply.—</h3> We read Flewellen's comment with interest. We still maintain that trying to differentiate patients susceptible to MH from normal individuals by measurement of serum creatine kinase levels is not valid. In fact, Flewellen's own data support our argument. Among the 25 patients who were halothane positive (excluding those with myopathies), only nine (36%) had elevated serum creatine kinase levels; ie, the determination of serum creatine kinase values missed almost two thirds of the patients who were MH susceptible. Among the patients who were halothane-caffeine sensitive, the values for serum creatine kinase was normal in 87%. Among the patients with negative contracture test results, the only elevated serum creatine kinase levels were found in two boys with myopathy. All of our patients were screened for myopathy, clinically by a careful examination of their motor system and pathologically by routine histological and histochemical studies of fresh-frozen muscle specimens. It would
Genetic homogeneity but IgG subclass–dependent clinical variability of alloimmune membranous nephropathy with anti-neutral endopeptidase antibodies
Authors: Marina Vivarelli, Francesco Emma, Thimothée Pellé, Christopher Gerken, Stefania Pedicelli, Francesca Diomedi-Camassei, Günter Klaus, Siegfried Waldegger, Pierre Ronco, Hanna Debiec
Journal: Kidney International (2015)
False-Positive Splenic Activity on Bone Scan
Authors: NICHOLAS C. FRIEDMAN, RICHARD P. SPENCER
Journal: Clinical Nuclear Medicine (1995)

A Tc-99m MDP bone scan in a woman revealed splenic uptake of radlolabel. However, the previous (and the following) bone scan did not demonstrate this extraosseous accumulation. The finding was related to a cardiac blood pool scan the previous day, with probable splenic pooling of labeled and denatured red blood cells.
Care for all at the end of life
Authors: Scott A Murray, Aziz Sheikh
Journal: BMJ (2008)

<b>Scott Murray</b> and <b>Aziz Sheikh</b> say that the lessons learnt from palliative care for cancer need to be applied to other fatal conditions. Healthcare delivery that is tailored to the varying needs of patients with these diseases will be crucial in making a difference, says <b>Joanne Lynn</b> (doi: 10.1136/bmj.39535.656319.94)
Posttransplantation HBV vaccination: Not an effective strategy in the prophylaxis of HBV recurrence
Authors: Z. Karasu, Y. Tokat, U.S. Akarca, A. Celebi, C. Arikan, M. Kilic, D. Nart, T. Ozacar, T. Demirbas, S. Erensoy, F. Gunsar, G. Ersoz, Y. Batur
Journal: Journal of Hepatology (2003)
Molecular mechanisms involving sigma receptor–mediated induction of MCP-1: implication for increased monocyte transmigration
Authors: Honghong Yao, Yanjing Yang, Kee Jun Kim, Crystal Bethel-Brown, Nan Gong, Keiko Funa, Howard E. Gendelman, Tsung-Ping Su, John Q. Wang, Shilpa Buch
Journal: Blood (2010)
Elevated plasma levels of thymus and activation-regulated chemokine (TARC) and macrophage-derived chemokine (MDC) in patients with atopic dermatitis and asthma
Authors: Hajime Katsumata, Takao Fujisawa, Yoshiko Kato, Jun Atsuta, Kosei Iguchi, Hitoshi Kamiya, Chiharu Okada, Kiyoshi Takahashi, Akio Mori, Kazuo Akiyama
Journal: Journal of Allergy and Clinical Immunology (2002)
Medicare as Secondary Payer
Authors: Patrick C. Donahue
Journal: JAMA (1988)

<h3>To the Editor.—</h3> Recently, Dr Roper,<sup>1</sup>administrator of the Health Care Financing Administration (HCFA), outlined the current rules concerning when Medicare pays on a primary basis and when it considers itself as secondary payer. Among other points, he stated that "Medicare [is] the secondary payer for beneficiaries who are eligible through their entitlement to Social Security disability payments and who are also covered by a large group health plan through their own employment or that of a family member." At the same time, Kathleen A. Buto, acting director of the HCFA's Bureau of Eligibility, Reimbursement and Coverage, informed FMC Corporation that the HCFA has not yet been able to decide whether disabled former employees are covered under the Medicare secondary payer provision and that therefore "Medicare will pay conditional primary benefits on future claims, subject to possible recovery from the group health plan if it is decided that Medicare
DISPENSING VERSUS PRESCRIBING.
Authors: M. H. FUSSELL
Journal: JAMA (1906)

Much is written in various medical journals, much is spoken by men, leaders in the medical profession, of the nostrum evil, of the impropriety of physicians using any preparation of drugs the full formula of which is not known. Many writers, with great justice it seems to me, insist, as Billings has done in a recent article, that mixtures put out by manufacturing firms, especially when such compounds contain on their labels the various diseases for which it is a specific, are just as objectionable as various secret remedies in which we are not certain of the exact proportions of the various ingredients. Sal vitæ has on its label a list of fourteen or fifteen ingredients said to be in the compound. It also states just exactly the therapeutic use of each supposed ingredient. It is a blotch on the escutcheon of a manufacturing pharmacist. A certain preparation containing eight
Comparison of expression profiles induced by dust mite in airway epithelia reveals a common pathway
Authors: A. B. Vroling, M. J. Jonker, T. M. Breit, W. J. Fokkens, C. M. van Drunen
Journal: Allergy (2008)

Background: Airway epithelial cells have shown to be active participants in the defense against pathogens by producing signaling and other regulatory molecules in response to the encounter. Methods: In previous manuscripts, we have studied the effect of house dust mite (HDM) extract on both an epithelial cell‐line (H292) and primary nasal epithelial cell. When we compare these responses we conclude that the H292 cells more closely resemble nasal epithelium of healthy controls (share 107 probe‐sets) than of allergic individuals (share 17 probe‐sets). Results: Interestingly, probably because of an absent intraindividual variation between samples, more probe‐sets (8280) change expression significantly in H292 than in either healthy (555) or allergic (401) epithelium. Conclusions: A direct comparison of all the responses in these epithelial cells reveals a core‐response to HDM of just 29 genes. These genes (CCL20, IL‐8, CXCL2, CXCL1, IL‐1B, AREG, TNFAIP3, HBEGF, PTGS2, BMP2, LDLR, PLAUR, PLAU, NFKB2, NFKB1, JUN, ATF3, EGR1, NPC1, TICAM1, EPHA2, CTGF, DUSP1, SPRY1, TLR‐3, complement factor C3, IVNS1ABP, SerpinB3, and PSAT1) have described links with allergy or inflammation and may even describe the well‐established relationship between viral infections and allergic exacerbations or allergy development.
86th Annual Report on Medical Education in the United States
Authors: Anne E. Crowley
Journal: JAMA (1986)

This is the 86th EDUCATION ISSUE ofThe Journal. The first report on medical education in the United States was published in the Sept 21, 1901, issue of JAMA .  HIGHLIGHTS OF THE 1986 Education Issue Editorial  Dr Richard L. Egan's editorial identifies several factors in the environment of US medical education that threaten the current system. He argues that any changes in the locale and/or method of educating future physicians must take into account the patient as an essential resource for the educational program.  Special Studies  A special study on foreign medical school graduates (FMGs) reveals details on the location of programs and institutions training FMGs. The programs with FMG residents were concentrated in seven states and Puerto Rico and had 35% of all residents but 64% of all FMG residents. The Middle Atlantic region, which includes New Jersey, New York, and Pennsylvania, had 24% of all residents but 47%
1169-151 Prediction of reversible left ventricular dysfunction: Comparison of contrast-enhanced magnetic resonance imaging and thallium-201 SPECT
Authors: Matthias Regenfus, Robert Krähner, Christian Schlundt, Johannes von Erffa, Michaela Schmidt, Niels Oesingmann, Günther Platsch, Torsten Kuwert, Werner G Daniel
Journal: Journal of the American College of Cardiology (2004)
Chemotherapy of Localized Inoperable Malignant Tumors of Children
Authors: David H. James, Phillip George, Omar Hustu, Earle Wrenn, Luis Borella, Kathleen Hernandez, Donald Pinkel
Journal: JAMA (1964)

DESPITE IMPROVEMENTS in surgical techniques and radiotherapy, malignant solid tumors of children have remained, by and large, fatal diseases.<sup>1</sup>This poor outlook has not been modified appreciably by the general improvement in wellchild supervision that has taken place in recent years. During the past decade several new drugs have been found to have limited activity against various types of childhood cancer. The use of these drugs, however, for the treatment of inoperable malignant tumors has most often been reserved for those children in whom every effort has first been made to eradicate as much of the disease as possible by surgical excision, radiation therapy, or a combination of these two modalities. The use of chemotherapy to render inoperable tumors operable, and the use of radiation therapy to prolong or augment a chemotherapy-induced tumor regression have been suggested as possible approaches to the management of inoperable malignant solid tumors of
Management of Medical Problems in Surgical Patients
Authors: Richard L. Byyny
Journal: JAMA (1983)

It was great fun to review this new text, Management of Medical Problems in Surgical Patients . There is no question that there is a great need for this type of text. There has been no available textbook to assist consultants to general surgeons and surgical specialists in dealing with medical problems in their patients. The editor points out clearly that much practical information has been gathered from a diversity of sources to provide a single source of information. He also points out that the authors have been careful to avoid dogmatic approaches. This is laudable, but, in a field like this where there often is insufficient information in the literature but where experienced clinicians have empiric observations from their practice, more bias might be useful to the reader.  It is also pointed out that an attempt was made to prevent the text from becoming another large text-book of medicine. Although
Fibrillation of head of radius as one cause of tennis elbow.
Authors: J H Newman, J W Goodfellow
Journal: BMJ (1975)

Twenty-five patients with resistant tennis elbow were treated by exploration of the radio-humeral joint. Twenty cases showed abnormalities of the cartilage of the head of the radius. Division of the orbicular ligament and excision of the abnormal cartilage gave good results in 19 to 20 cases seen recently. We believe fibrillation of the head of the radius is an important cause of tennis elbow, and the arguments to support this theory are enumerated.
Recruitment of plasmacytoid dendritic cells in ultraviolet irradiation-induced lupus erythematosus tumidus
Authors: G. Obermoser, P. Schwingshackl, F. Weber, G. Stanarevic, B. Zelger, N. Romani, N. Sepp
Journal: British Journal of Dermatology (2008)

Journal Article Recruitment of plasmacytoid dendritic cells in ultraviolet irradiation‐induced lupus erythematosus tumidus Get access G. Obermoser, G. Obermoser Department of Dermatology and Venereology, Innsbruck Medical University, Anichstrasse 35, 6020 Innsbruck, Austria E‐mail: gerlinde.obermoser@i‐med.ac.at Search for other works by this author on: Oxford Academic Google Scholar P. Schwingshackl, P. Schwingshackl Department of Dermatology and Venereology, Innsbruck Medical University, Anichstrasse 35, 6020 Innsbruck, Austria Search for other works by this author on: Oxford Academic Google Scholar F. Weber, F. Weber Department of Dermatology and Venereology, Innsbruck Medical University, Anichstrasse 35, 6020 Innsbruck, Austria Search for other works by this author on: Oxford Academic Google Scholar G. Stanarevic, G. Stanarevic Department of Dermatology and Venereology, Innsbruck Medical University, Anichstrasse 35, 6020 Innsbruck, Austria Search for other works by this author on: Oxford Academic Google Scholar B. Zelger, B. Zelger Department of Dermatology and Venereology, Innsbruck Medical University, Anichstrasse 35, 6020 Innsbruck, Austria Search for other works by this author on: Oxford Academic Google Scholar N. Romani, N. Romani Department of Dermatology and Venereology, Innsbruck Medical University, Anichstrasse 35, 6020 Innsbruck, Austria Search for other works by this author on: Oxford Academic Google Scholar N. Sepp N. Sepp Department of Dermatology and Venereology, Innsbruck Medical University, Anichstrasse 35, 6020 Innsbruck, Austria Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 160, Issue 1, 1 January 2009, Pages 197–200, https://doi.org/10.1111/j.1365-2133.2008.08873.x Published: 01 January 2009
Human papillomavirus 16/18 AS04-adjuvanted vaccine prevented cervical intraepithelial neoplasia in young women
Authors: Kavita Nanda
Journal: Annals of Internal Medicine (2009)

Source Citation Paavonen J, Naud P, Salmerón J, et al. Efficacy of human papillomavirus (HPV)-16/18 AS04-adjuvanted vaccine against cervical infection and precancer caused by oncogenic HPV types (PATRICIA): final analysis of a double-blind, randomised study in young women. Lancet. 2009;374:301-14. 19586656
Molecular medicine: promises, promises?
Authors: M. Steel
Journal: Journal of the Royal Society of Medicine (2005)

Within the past few months, Francis Crick and Maurice Wilkins, two of the three men who won a Nobel Prize for describing the structure of DNA, have died. Their obituaries revisited the famous 1953 Nature papers,1,2 recalling with relish the classic English understatement ‘It has not escaped our notice that the specific pairing we have postulated immediately suggests a possible copying mechanism for the genetic material’. In reality, Crick, at least, was less subdued, bursting in to the Eagle tavern in Cambridge with James Watson and declaiming to the doubtless bemused clientele ‘we have found the secret of life’.3,4
Biochemical studies of two patients with the gray platelet syndrome. Selective deficiency of platelet alpha granules.
Authors: J M Gerrard, D R Phillips, G H Rao, E F Plow, D A Walz, R Ross, L A Harker, J G White
Journal: Journal of Clinical Investigation (1980)

The biochemistry of platelets from two unrelated patients with the gray platelet syndrome, a deficiency of platelet alpha-granules, has been evaluated. Ultrastructural studies of their platelets revealed the number of alpha-granules to be less than 15% of normal, whereas the number of dense bodies was within normal limits. Platelets from both patients had severe deficiencies of platelet factor 4 and beta-thromboglobulin (less than 10% of normal). Sodium dodecyl sulfate-polyacrylamide gel electrophoresis showed a marked deficiency of thrombin-sensitive protein in both patients. Analysis of the platelet-derived growth factor in one patient showed it was also markedly reduced. Levels of lysosomal enzymes, adenine nucleotides, serotonin, and catalase, and conversion of arachidonic acid by the lipoxygenase and cyclo-oxygenase enzymes, were within normal limits. The results provide important evidence to define the contents of alpha-granules and to differentiate these contents from the contents of lysosomal granules, dense bodies, and peroxisomes. Functional studies of these platelets showed deficiencies in ADP, thrombin, and collagen aggregation. The results suggest that alpha-granules or their contents make a contribution to normal platelet aggregation.
Homozygous deletion of SOCS1 in primary mediastinal B-cell lymphoma detected by CGH to BAC microarrays
Authors: C Mestre, F Rubio-Moscardo, A Rosenwald, J Climent, M J S Dyer, L Staudt, D Pinkel, R Siebert, J A Martinez-Climent
Journal: Leukemia (2005)
The Day Donny Herbert Woke Up: A True Story
Authors: Joseph J. Fins
Journal: JAMA (2008)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Fall in suicides among mental health patients linked to improvements in mental health services
Authors: I. Torjesen
Journal: BMJ (2012)

Suicides among vulnerable mental health patients have fallen in England and Wales as a result of mental health trusts implementing best practice recommendations, after the move to providing more care into the community, a study has found.

The study, published in the Lancet (doi:10.1016/S0140-6736(11)61712-1), assessed whether nine recommendations made by the National Confidential Inquiry into Suicide and Homicide by People with Mental Illness more than a decade ago ( BMJ 2001;322:633.2) had been implemented by 91 mental health trusts in England and Wales, and whether the recommendations had made any difference to the suicide rates of …
Conference recommends joint training for doctors and health service managers
Authors: S. Mayor
Journal: BMJ (2003)

The education and training of doctors and NHS managers should ensure that each group understands the other better, recommended a report published this week.

The report was of a multidisciplinary conference organised by the NHS Confederation and held on 27 March. The conference was part of an initiative to improve relationships between the two groups of professionals as they work together in the NHS.

Representatives from the medical royal colleges, the BMA, the Joint Consultants Committee, NHS organisations, and the Department of Health agreed that the currently poor relations between …
The Characteristics of Renal Hypoperfusion in Dogs with Acute and Chronic Reductions in Glomerular Filtration Rate as Disclosed by the Pattern of Water and Solute Excretion after Hypotonic Saline Infusions *
Authors: George Van Giesen, Merrick Reese, Fredrik Kiil, Floyd C. Rector, Donald W. Seldin
Journal: Journal of Clinical Investigation (1964)

Under ordinary circumstances the elaboration of a dilute urine is dependent upon suppression of the secretion of antidiuretic hormone (ADH).Even when ADH secretion is maximally sup- pressed, however, a concentrated urine may be formed.Berliner and Davidson (1), del Greco and de Wardener (2), and Kleeman, Maxwell, and Rockney (3) have demonstrated that a reduction in glomerular filtrationi rate (GFR) can result in the excretion of hypertonic urine in the absence of ADH activity.The factors responisible for urinary hyper- tonicity under these conditionis have niot been com- pletely elucidated.Del Greco and de Wardener (2) have attributed the hypertonicity to the ef- fects of diminished total solute excretion.Ber- liner and Davidson (1), on the other hand, re- gard the hypertonicity as the result of reduced delivery of sodium salts to the diluting segment, in consequence of whiclh free water formation is drastically reduced; if the distal portions of the nephroni in the absence of ADH were even iiini- mally permeable to water, back diffusion of only a sml-all amiiount of free water would theni renider the urinle hypertonic.However, Leaf, Kerry, \Vrong, and Chatillon (4) failed to demonstrate any rise in urinary tonicity during water diuresis despite significant reductions in GFR.
Positive conversion of negative signaling of CTLA4 potentiates antitumor efficacy of adoptive T-cell therapy in murine tumor models
Authors: Jae Hun Shin, Hyung Bae Park, Yu Mi Oh, Dong Pyo Lim, Ji Eun Lee, Hae Hyun Seo, Sang Jin Lee, Hyeon Seok Eom, In-Hoo Kim, Seung Hoon Lee, Kyungho Choi
Journal: Blood (2012)
Hepatitis from Corned Beef?
Authors: P. W. Bothwell
Journal: BMJ (1964)

Deaths from Smoking SIR,-Your leading article of 6 June (p.1451) comments on remarks which I made recently.I would like to take this oppor- tunity to answer some of the points raised.It was not my intention to deny or to minimize the association of cigarette-smoking to the incidence of bronchial carcinoma.I agree that the frequency of this disease is reflected in the extent of individual cigarette consumption.I recognize that although the development of bronchial carcinoma is materially less in light smokers than in heavy smokers the evidence available shows that smoking cigar- ettes, even in small numbers, adds to the hazard in comparison with non-smokers.I would like, therefore, to make it clear that the views of the Imperial Cancer
Genome-wide association study identifies two susceptibility loci for nonsyndromic cleft lip with or without cleft palate
Authors: Elisabeth Mangold, Kerstin U Ludwig, Stefanie Birnbaum, Carlotta Baluardo, Melissa Ferrian, Stefan Herms, Heiko Reutter, Nilma Almeida de Assis, Taofik Al Chawa, Manuel Mattheisen, Michael Steffens, Sandra Barth, Nadine Kluck, Anna Paul, Jessica Becker, Carola Lauster, Gül Schmidt, Bert Braumann, Martin Scheer, Rudolf H Reich, Alexander Hemprich, Simone Pötzsch, Bettina Blaumeiser, Susanne Moebus, Michael Krawczak, Stefan Schreiber, Thomas Meitinger, Hans-Erich Wichmann, Regine P Steegers-Theunissen, Franz-Josef Kramer, Sven Cichon, Peter Propping, Thomas F Wienker, Michael Knapp, Michele Rubini, Peter A Mossey, Per Hoffmann, Markus M Nöthen
Journal: Nature Genetics (2009)
Prolonged Remissions in Acute Myelocytic Leukemia in Adults
Authors: Virgil F. Fairbanks
Journal: JAMA (1968)

Three adult patients with acute myelocytic leukemia have been observed with complete remissions lasting from 2 1/2 to 9 1/2 years. Maintenance chemotherapy was not required during the period of remission. During the time in which these patients were treated initially, there were 177 other adults with acute myelocytic leukemia. Eight of these had complete remissions of six months' duration or less. No clinical, laboratory, or therapeutic differences distinguished those patients who experienced remission from those who did not. The infrequency of remission in patients above the age of 45 was confirmed. Five patients were observed to have relatively prolonged survival despite the failure of therapy to induce remission of clinically indolent, "smoldering" leukemia which was acute on morphologic grounds. Mechanisms as yet unrecognized, and possibly inherent in the host, may have been predominant in determining the course and prognosis.