tbuckley/cabot-search huggingface dataset:
Radioimmunoassay of β-MSH in Human Plasma and Tissues*
Authors: Kaoru Abe, Wendell E. Nicholson, Grant W. Liddle, Donald P. Island, David N. Orth
Journal: Journal of Clinical Investigation (1967)

A radioimmunoassay method for beta-melanocyte-stimulating hormone (beta-MSH) has been developed and utilized in the identification and quantification of this hormone in human plasma and tissues. The concentration of beta-MSH in two human pituitary glands was found to be approximately 350 mug/g. beta-MSH was identified in the tumor tissue of all 11 patients with the ectopic ACTH syndrome who were studied; concentrations in individual cases ranged from 3 to 1600 ng/g. In plasma of chronically hyperpigmented patients with Addison's disease, Cushing's disease (after bilateral adrenalectomy), and the ectopic ACTH syndrome, beta-MSH concentrations of 0.5-6 ng/ml were found. The degree of clinical hyperpigmentation was well correlated with the quantity of beta-MSH in the plasma. beta-MSH concentrations in the plasma of normal subjects were less than 0.09 ng/ml. In all of these circumstances, bioassays for MSH were also performed, and it was found that most of the biologic MSH activity of the plasma and tissues could be accounted for by beta-MSH.
Ordeal by Investigation
Authors: D. E. L. Howes
Journal: BMJ (1973)

The action on the isolated frog heart has been studied of four unsaturated lactones, namely, βγ-angelicalactone, αβ-angelicalactone, crotonolactone γ-acetic acid, and methyl ester of crotonolactone γ-acetic acid. They cause an increase in the amplitude of contraction followed by a period of diminished relaxation of the ventricle which terminates in systolic standstill. The angelicalactones improve the activity of the heart made hypodynamic by perfusion with calcium-poor salt solution. A quantitative comparison of the systolic action showed that the βγ-angelicalactone is considerably more potent than the three αβ-unsaturated lactones.
Recent Mortality from Pleural Mesothelioma, Historical Patterns of Asbestos Use, and Adoption of Bans: A Global Assessment
Authors: Kunihito Nishikawa, Ken Takahashi, Antti Karjalainen, Chi-Pang Wen, Sugio Furuya, Tsutomu Hoshuyama, Miwako Todoroki, Yoshifumi Kiyomoto, Donald Wilson, Toshiaki Higashi, Megu Ohtaki, Guowei Pan, Gregory Wagner
Journal: Environmental Health Perspectives (2008)

In response to the health risks posed by asbestos exposure, some countries have imposed strict regulations and adopted bans, whereas other countries have intervened less and continue to use varying quantities of asbestos.
Networking request from a pharmaceutical company?
Authors: BJ Visser
Journal: The Lancet (2011)

Increasing numbers of medical practitioners and medical students are using online social and business-related networking websites such as Facebook, MySpace, LinkedIn, Doc2Doc, and Twitter to facilitate networking opportunities and find ways to associate with others who have similar interests, research activities, or professions. Professional networking websites such as LinkedIn are being used more and more by health-care professionals, with more than 120 million total users worldwide.1 LinkedIn can be used to connect with current or former colleagues, find jobs, follow groups or companies, and upload a résumé (curriculum vitae).
Spatial Heterogeneity of Endothelial Phenotypes Correlates With Side-Specific Vulnerability to Calcification in Normal Porcine Aortic Valves
Authors: Craig A. Simmons, Gregory R. Grant, Elisabetta Manduchi, Peter F. Davies
Journal: Circulation Research (2005)

Calcific aortic valve sclerosis involves inflammatory processes and occurs preferentially on the aortic side of endothelialized valve leaflets. Although the endothelium is recognized to play critical roles in focal vascular sclerosis, the contributions of valvular endothelial phenotypes to aortic valve sclerosis and side-specific susceptibility to calcification are poorly understood. Using RNA amplification and cDNA microarrays, we identified 584 genes as differentially expressed in situ by the endothelium on the aortic side versus ventricular side of normal adult pig aortic valves. These differential transcriptional profiles, representative of the steady state in vivo, identify globally distinct endothelial phenotypes on opposite sides of the aortic valve. Several over-represented biological classifications with putative relevance to endothelial regulation of valvular homeostasis and aortic-side vulnerability to calcification were identified among the differentially expressed genes. Of note, multiple inhibitors of cardiovascular calcification were significantly less expressed by endothelium on the disease-prone aortic side of the valve, suggesting side-specific permissiveness to calcification. However, coexisting putative protective mechanisms were also expressed. Specifically, enhanced antioxidative gene expression and the lack of differential expression of proinflammatory molecules on the aortic side may protect against inflammation and lesion initiation in the normal valve. These data implicate the endothelium in regulating valvular calcification and suggest that spatial heterogeneity of valvular endothelial phenotypes may contribute to the focal susceptibility for lesion development.
The Effect of Chlorpromazine on the Swallowing Function in Chronic Schizophrenic Patients
Authors: ALLEN E. HUSSAR, DAVID G. BRAGG
Journal: American Journal of Psychiatry (1969)

In a cineradiographic study of swallowing in four groups of subjects, it was found that chlorpromazine had no effect on the swallowing mechanism in schizophrenics. Half of the schizophrenic patients showed cineradiographic abnormalities in swallowing. These results contribute to an understanding of sudden deaths due to asphyxiation by food frequently ascribed to tranquilizing medication in schizophrenic patients.
Exposure to Lead in Childhood
Authors: Kathryn R. Mahaffey
Journal: New England Journal of Medicine (1992)

Baghurst et al.1 are to be congratulated for continuing their long-term studies of intellectual deficits in children who were exposed to lead in early childhood. These investigators have identified deficits in intelligence, not just delays in neurobehavioral or motor development, among school-age children that are associated with exposure to lead in early childhood. That children's intellectual performance can be diminished by environmental exposure to a chemical as common as lead appears to startle many. This association has been attacked in both the popular press and the scientific literature. The principal counterassertion is that such deficits are due to other factors . . .
THE PSYCHOLOGIST LOOKS AT THE DOCTOR
Authors: JOSEPH JASTROW
Journal: JAMA (1927)

I am aware to the point of embarrassment that a psychologist may look at a doctor only from that lowly position of privilege and reverence from which a cat may look at a king; nor have I any designs, feline or otherwise, to psychoanalyze the doctor and disclose any unpresentable repressions or complexes detrimental to the prestige that is the most valuable instrument in his formidable black-bag. As a prescription that I shall presently consider concerns the dissipation of fear, I offer this dose of assurance, in place of any more acceptable consolation suppressed by the freudian censor under the name of Volstead. Nor have I any thesis of startling novelty which might lead you to suspect it as a radical innovation. What I have to say is in the air, or, as we now say,<i>on</i>the air, and night be board-cast from any medical station in tune
Antithrombin III‐Amiens: A new family with an Arg<sup>47</sup> → cys inherited variant of antithrombin iii with impaired heparin cofactor activity
Authors: B. Roussel, J. Dieval, J. Delobel, F. Fernandez‐Rachubinski, B. Eng, R. A. Rachubinski, M. A. Blajchman
Journal: American Journal of Hematology (1991)

Abstract A family with an antithrombin III variant (AT‐III‐Amiens) demonstrating abnormal heparin cofactor activity is described. Amplification and direct sequencing of genomic DNA by the polymerase chain reaction procedure permitted the identification of an Arg 47 Cys mutation in exon 2 of the variant antithrombin III gene.
Alterations of rabbit aortic smooth muscle cell proliferation in diabetes mellitus
Authors: C Alipui, K Ramos, T E Tenner
Journal: Cardiovascular Research (1993)

Journal Article Alterations of rabbit aortic smooth muscle cell proliferation in diabetes mellitus Get access C Alipui, C Alipui Department of Pharmacology, Texas Tech University Health Sciences Center, Lubbock, Texas 79430, USA: C Alipui, T E Tenner; Department of Veterinary Physiology and Pharmacology, Texas A & M University, College Station, Texas, USA: K Ramos. Correspondence to Dr Tenner. Search for other works by this author on: Oxford Academic PubMed Google Scholar K Ramos, K Ramos Department of Pharmacology, Texas Tech University Health Sciences Center, Lubbock, Texas 79430, USA: C Alipui, T E Tenner; Department of Veterinary Physiology and Pharmacology, Texas A & M University, College Station, Texas, USA: K Ramos. Search for other works by this author on: Oxford Academic PubMed Google Scholar T E Tenner, Jr T E Tenner, Jr Department of Pharmacology, Texas Tech University Health Sciences Center, Lubbock, Texas 79430, USA: C Alipui, T E Tenner; Department of Veterinary Physiology and Pharmacology, Texas A & M University, College Station, Texas, USA: K Ramos. Search for other works by this author on: Oxford Academic PubMed Google Scholar Cardiovascular Research, Volume 27, Issue 7, July 1993, Pages 1229–1232, https://doi.org/10.1093/cvr/27.7.1229 Published: 01 July 1993 Article history Received: 08 December 1992 Accepted: 19 February 1993 Published: 01 July 1993
Letter: Medicine and the Common Market.
Authors: K Liddell
Journal: BMJ (1974)

20-month-old baby, who developed a roseolar rash at the same time.Among the types of virus isolated from throat or faecal specimens from my patients at the time of their roseolar reactions were adenovirus 2, 3, and 14, echovirus 9, 11, 27, and 30, Cox- sackie A6 and 9, Coxsackie B2, 4, and 5, and parainfluenza type 1.Most children who received the earlier, less attenuated, measles virus vaccines developed a roseolar reaction as their fever subsided.This rash differed from that of measles in two respects: it began on the trunk instead of the face and it appeared as the tempera- ture dropped and not at the start of the secondary fever.Children who undergo either the fast ("one-spike") or the slow (roseolar) febrile immunizing reaction are as a rule otherwise healthy and free from any localizing signs of infection in the ears, nose, throat, chest, abdomen, or urine.The younger the child, the higher is the temperature likely to be.Presumably the roseolar rash is due to virus particles being neutralized in the skin at the end of a period of viraemia.Perhaps viraemia does not occur in the "one-spike" fever and so no rash appears.Please may sixth disease now disappear from the next edition of textbooks?-Iam, etc., G. I.
Multifocal primary salivary-type adenocarcinoma of the esophagus
Authors: M. Pollheimer, V. Pollheimer, A. Eherer, C. Langner
Journal: Endoscopy (2007)

An 83-year-old woman presented with a history of dysphagia and a 10-kg weight loss over a 6-month period. On endoscopy, multiple glassy-looking polyps were seen in the upper and middle thirds of the esophagus (Figure [1 a]). No Barrett’s metaplasia was observed in the distal esophagus. Biopsy specimens taken from the polyps revealed multifocal adenocarcinoma originating from the ducts of esophageal mucus glands. The lesions showed extensive mucus production and were located mainly in the submucosal layer, undermining non-neoplastic squamous epithelium (Figure [1 b]). There were micropapillary in-situ formations as well as foci of overt, infiltrating, poorly differentiated cancer (Figure [1 c]). The patient refused further evaluation and therapy.
Improved myocardial ischemic response and enhanced collateral circulation with long repetitive coronary occlusion during angioplasty: A prospective study
Authors: Alain Cribier, Luis Korsatz, René Koning, Pratap Rath, Habib Gamra, Gunter Stix, Shahid Merchant, Charles Chan, Brice Letac
Journal: Journal of the American College of Cardiology (1992)
The brilliance but horrendousness of dialysis
Authors: T. Delamothe
Journal: BMJ (2012)

“There was death at its beginning as there would be death again at its end.” So begins Nicholas Evans’s bestselling novel, The Horse Whisperer . Evans could be forgiven for wondering whether his own death was on the cards in the days after he and his wife ate some deadly mushrooms four years ago. “We had black diarrhoea and nausea and retched every few minutes until all that came was blood and bile,” he tells us in his Patient’s Journey article (doi:10.1136/bmj.e5262). Their renal function almost completely disappeared, and they were saved by haemodialysis and ultimately renal transplantation.

It’s a great read with …
Diffuse alveolar hemorrhage with underlying isolated, pauciimmune pulmonary capillaritis.
Authors: C A Jennings, T E King, R Tuder, R M Cherniack, M I Schwarz
Journal: American Journal of Respiratory and Critical Care Medicine (1997)

Diffuse alveolar hemorrhage (DAH) resulting from pulmonary capillaritis typically accompanies the systemic vasculitides and collagen vascular diseases. Isolated pulmonary capillaritis and DAH without systemic disease occurs in patients with antineutrophil cytoplasmic antibodies. However, isolated pulmonary capillaritis and DAH is not described for patients without clinical or serologic evidence for an underlying systemic disease. To describe such patients, we undertook a retrospective chart review of 29 patients with DAH and biopsy-proven pulmonary capillaritis from seven Denver hospitals. Eight (28%) were diagnosed with isolated pulmonary capillaritis without clinical, serologic, or histologic evidence of an associated illness. Their median age was 30 yr. No association with occupational or drug exposures was identified. All had lower respiratory tract symptoms; seven had upper respiratory tract symptoms. None demonstrated systemic disease or evidence of glomerulonephritis. All were antineutrophil cytoplasmic antibody negative. Other serologies were not significant where measured. Direct immunofluorescence studies of lung tissue were negative in five. Six presented with acute respiratory failure, four requiring mechanical ventilation. One died during initial hospitalization; seven survived. Median follow-up is 43 mo (7 to 73 mo). Five remain in remission. Two experienced multiple recurrences of DAH but without development of systemic disease while on therapy. Herein we characterize DAH and isolated pulmonary capillaritis in the absence of clinical, serologic, or histologic evidence indicating an accompanying systemic illness. The prognosis for this group appears favorable.
Don't Call Me “Nudge”: The Ethical Obligation to Use Effective Interventions to Promote Public Health
Authors: Azgad Gold, Pesach Lichtenberg
Journal: The American Journal of Bioethics (2012)

The word “nudge” bears two alternate meanings. According to the positive connotation of the word—“to push gently in order to get someone's attention” or “to prod someone into action”—nudge represen...
Introduction of a low pressure suction system for day case large volume paracentesis: results from a scottish teaching hospital
Authors: E. Reed, A. Stanley, E. Forrest, R. Gillespie, M. Neilson, S. Barclay
Journal: Gut (2011)

<h3>Introduction</h3> In most centres including our own, large volume paracentesis (LVP) has traditionally been performed under free drainage. The authors sought to evaluate the safety and efficacy of a low pressure suction system during its introduction to their gastroenterology day ward. <h3>Methods</h3> A low pressure suction controller was plugged in to a standard wall suction point, and adjusted to provide 100 mm Hg of suction. Ascites was drained using either a Safe-T-Centesis or Bonanno catheter and collected in a Vacsax suction carousel. As per our local protocol, 20 g of salt poor albumin was given per 3 l of ascites drained. Blood pressure and heart rate were recorded every 30 min. The total volume of fluid, duration of drainage and any complications were recorded. Flow rate was then calculated in l/min. Similar data was also collected from patients undergoing free drainage paracentesis, which was used while all nursing staff were familiarised with the suction. <h3>Results</h3> 14 patients (9 male, 5 female) with large volume ascites underwent 46 episodes of LVP (29 cases ALD, 11 cases NAFLD, 6 malignant ascites – was albumin given to these malignant patients?). 27 LVPs were performed under suction and 19 under free drainage. Compared to free drainage procedures, suction LVPs took significantly less time (mean duration 233.9±59.1 vs 279.7±61.1 min, p=0.01). Suction LVPs drained similar volumes (10.45±4.1 vs 9.6±3.8 l, NS) and achieved similar mean flow rates (0.048±0.021 vs 0.035±0.014 l/min, NS). One patient undergoing suction LVP developed transient mild abdominal pain that settled spontaneously. No patients in either group experienced significant complications. <h3>Conclusion</h3> Low pressure suction paracentesis is significantly faster than free drainage procedures, and can be easily introduced in a day case setting. The benefits to patient and nursing time combined with excellent safety have led the authors to continue low pressure LVP as standard care on their gastroenterology day ward.
Imatinib dose increase up to 1200 mg daily can induce new durable complete cytogenetic remissions in relapsed Ph+ chronic myeloid leukemia patients
Authors: R G Piazza, V Magistroni, F Andreoni, A Franceschino, L Tornaghi, M Varella-Garcia, S Bungaro, F Colnaghi, G Corneo, E M Pogliani, C Gambacorti-Passerini
Journal: Leukemia (2005)
Clinically silent infections in patients with oligoarthritis: results of a prospective study.
Authors: C M Weyand, J J Goronzy
Journal: Annals of the Rheumatic Diseases (1992)

Oligoarticular synovitis of undetermined origin can closely resemble an incomplete form of reactive arthritis/Reiter9s syndrome. Eighty three patients with oligoarthritis of undetermined origin were studied prospectively to identify asymptomatic infections potentially triggering the inflammatory response in the synovial fluid. At the time of initial evaluation, 57 (69%) of the patients with oligoarthritis and 4/20 (20%) of the control subjects were carriers of clinically silent infections. Evidence for persistent or prior chlamydial infections was frequently and exclusively found in the study group (30/83 (36%) patients v no controls), whereas undetected urogenital infections with mycoplasma were present in nine (11%) patients and four (20%) controls. Eleven (13%) of the patients carried cellular and humoral responses to Borrelia burgdorferi. The HLA-B27 haplotype represented a major risk factor for the development of oligoarthritis but not for development of sacroiliitis. Re-evaluation after one year showed that the course and outcome of the oligoarticular disease did not correlate with a specific infectious organism and were not affected by antibiotic treatment sufficient to treat the carrier state.
Synergistic effect of PGE1 and the calcium antagonist verapamil in disaggregation of aggregated platelets and inhibition of platelet aggregation induced by PAF-acether or arachidonic acid
Authors: Shah Nawaz Khan, S. Oppong, D.M. Conroy, A.D. Smith, K.J. Zilkha
Journal: Progress in Lipid Research (1986)
Violence in general practice
Authors: S. Cembrowicz
Journal: BMJ (1989)

and the screening study (0-6% of the entire adult population v 3-5% of the 2000 screened subjects visiting a primary care centre) is not surprising.A much larger fraction of patients visiting a primary care unit will be taking thyroxine than in the general population.Furthermore, the prevalence found in patients visiting the primary care centre agrees with our previous findings in subjects seeking hospital care.'
Ivan David Alexander Johnston
Authors: N Alan Green, Peter Craig
Journal: BMJ (2008)

During the early part of the second world war Ivan David Alexander Johnston moved to his grandparents’ farm in County Antrim and was educated at Ballymena Academy, later returning to the Royal Belfast Academical Institution. One excellent teacher of botany in medical school was Professor Flynn, the father of the flamboyant film star, Errol.

After qualification, Ivan did house appointments, the first being with (Sir) Ian Fraser, a charismatic and enthusiastic surgeon. With a leaning towards research, Ivan became a surgical tutor to the professorial unit under the guidance of Professor Harold Rodgers and Dick Welbourn. During 1959-60 he was research associate at the Mayo Clinic, Rochester, Minnesota, travelling to …
Gastrointestinal problems in the old. II.
Authors: D E Hyams
Journal: BMJ (1974)

Acute AbdomenThe acute abdomen often causes considerable problems in elderly patients.Its presentation may be atypical, its course more stormy with later diagnosis and a much greater likelihood of complications-especially at and after surgery.Old people are often less able to cope with their illness than are younger patients, so that early diagnosis becomes of major importance; yet these are often the very patients who are diagnosed late because of difficulties in communication, few or atypical symptoms, absence of "classical" physical signs, and difficulty in physical examination due to associ- ated degenerative or disease processes.Pain may be absent or
US researchers produce 17 new embryonic stem cell lines
Authors: Scott Gottlieb
Journal: BMJ (2004)

Researchers in the United States have derived and identified 17 new stem cell lines from human embryos, in addition to the 15 that are currently known to be available for publicly funded research in the United States.

The research, released on the internet this week by the New England Journal of Medicine (www.nejm.com), is bound to stir up controversy in a country where stem cell research is a highly contentious issue.

The new stem cell lines were derived from human …
South Africa's liberal abortion laws challenged
Authors: P. Sidley
Journal: BMJ (1998)

South Africa's liberal abortion law is being challenged in court by three Christian groups who say that the law goes against the constitutional guarantee of a “right to life.”

Around 40000 legal abortions have taken place since the law was liberalised last year. Before the law was changed, more than 400 women lost their lives every year after having back street abortions. The law allows for abortions virtually on demand at no …
On Authors and Contributors
Authors: Jeffrey M. Drazen, Gregory D. Curfman
Journal: New England Journal of Medicine (2002)

It is the responsibility of every person listed as the author of an article published in the Journal to have contributed in a meaningful and identifiable way to the design, performance, analysis, and reporting of the work. The specific requirements for authorship promulgated by the International Committee of Medical Journal Editors (ICMJE), which have been adopted by many biomedical journals, are posted on its Web site at http://www.icmje.org. By extension of this reasoning, it is logical that those who meet the criteria for authorship not be excluded as authors. However, our current editorial policy limits to 12 the number of . . .