HYPERINSULINISM DUE TO ADENOMA OF THE ISLETS OF LANGERHANS: CASE REPORT WITH METABOLIC STUDIES BEFORE AND AFTER REMOVAL OF TUMOR
Authors: Hildahl I. Burtness, Alfred E. Koehler, James H. Saint
Journal: Annals of Internal Medicine (1941)

Case Reports1 April 1941HYPERINSULINISM DUE TO ADENOMA OF THE ISLETS OF LANGERHANS: CASE REPORT WITH METABOLIC STUDIES BEFORE AND AFTER REMOVAL OF TUMORHILDAHL I. BURTNESS, M.D., ALFRED E. KOEHLER, M.D., JAMES H. SAINT, M.D., F.R.C.S. (Eng.), F.A.C.S.HILDAHL I. BURTNESS, M.D.Search for more papers by this author, ALFRED E. KOEHLER, M.D.Search for more papers by this author, JAMES H. SAINT, M.D., F.R.C.S. (Eng.), F.A.C.S.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-14-10-1915 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptAt the present time, the comparative rarity of cases of adenoma of the islets of Langerhans and the short time which has elapsed since the discovery of the condition and of its clinical significance, render each case of extreme interest to the medical men concerned in its diagnosis and in the discovery and removal of the tumor at operation. Moreover, our knowledge of the condition is still in the stage when it can be furthered by careful studies in any given case.Shortly after Banting and Best2announced their discovery of insulin in 1922 the clinical syndrome associated with hypoglycemia...References1. ÅKERBERG E: Hyperinsulinism and surgery, Acta. Chir. Scand., 1939, lxxxiii, 104. Google Scholar2. BANTINGBEST FGCH: Internal secretion of the pancreas, Jr. Lab. and Clin. Med., 1922, vii, 251. Google Scholar3. BERGONZI M: Basi anatomiche della ipoglicemia spontanea convulsivante: i tumori a cellule insulari del pancreas, Riv. sper. di freniat., 1939, lxiii, 161. Google Scholar4. CLARKE JM: A brief review of functional hyperinsulinism, with report of a case showing improvement after partial pancreatectomy, Austr. and New Zealand Jr. Surg., 1938, viii, 66. CrossrefGoogle Scholar5. COLLIPANDERSON JBEM: Studies on the thyrotropic hormone of the anterior pituitary, Jr. Am. Med. Assoc., 1935, civ, 965. CrossrefGoogle Scholar6. DUNCANHAYWARDFLICK GGGWJB: Hyperinsulinism: with report of two cases of adenoma of the islets of Langerhans, Med. Clin. N. Am., 1939, xxiii, 1481. CrossrefGoogle Scholar7. FORBESDAVIDSONDUNCAN RDSFJ: Hyperinsulinism due to tumor of the pancreas, West. Jr. Surg., Gynec. and Obst., 1939 (Feb.), xlvii, 76. Google Scholar8. FRASERMACLAYMANN RWSSA: Hyperinsulinism due to a pancreatic islet adenoma, Quart. Jr. Med., 1938, xxxi, 115. Google Scholar9. GRAYBURTNESS PAHI: Hypoglycemic headache, Endocrinology, 1935, xix, 549. CrossrefGoogle Scholar10. HARRIS S: Hyperinsulinism and dysinsulinism, Jr. Am. Med. Assoc., 1924, lxxxiii, 729. CrossrefGoogle Scholar11. HERMANNSENNESTMANN J: Hyperinsulinismus und Pankreasadenom, Klin. Wchnschr., 1938, xvii, 1589. CrossrefGoogle Scholar12. HOWLANDCAMPBELLMALTBYROBINSON GWREJWL: Dysinsulinism. Convulsions and coma due to islet cell tumor of the pancreas, with operation and cure, Jr. Am. Med. Assoc., 1929, xliii, 674. CrossrefGoogle Scholar13. JIRASEKPOSTRANECKY AO: Un cas d'adenome des ilots de Langerhans. Diagnostic—Operation—Guerison, Presse Med., 1938, xlvi, i, 672. Google Scholar14. JONESMATTE WAML: Tumor of the pancreas, with hypoglycemia, Med. Bull. Vet. Admin., 1938, xiv, 375. Google Scholar15. KOEHLERHILL AEE: Comparison of oral and intravenous glucose tolerance, Proc. Am. Soc. Biol. Chem., 1938, xxxvii, 19. Google Scholar16. KRAUSS H: Zur Klinik und Therapie des Pankreasadenomes, Deutsch. Ztschr. f. Chir., 1939, ccli, 512. CrossrefGoogle Scholar17. LEVISONRAMSEY LATL: Spontaneous hypoglycemia associated with pancreatic adenoma: case report with operation and autopsy, Ohio State Med. Jr., 1938, xxxiv, 869. Google Scholar18. MALAMUDGROSH NLC: Hyperinsulinism and cerebral changes, Arch. Int. Med., 1938, lxi, 579. CrossrefGoogle Scholar19. NICHOLSONHART WMD: Spontaneous hypoglycemia, New Internat. Clin., 1938, ii, 251. Google Scholar20. PARADEKINDLER GWK: Inselzellenadenom, durch Operation geheilt, Klin. Wchnschr., 1938, xvii, 810. CrossrefGoogle Scholar21. WESTKAHN HFM: Adenoma of the pancreas with hyperinsulinism. Two proved cases, cousins, with surgical cure in one, West. Jr. Surg., Gynec. and Obst., 1939, xlvii, 364. Google Scholar22. WHIPPLE AO: The surgical therapy of hyperinsulinism, Jr. Internat. de Chir., 1938, iii, 1. Google Scholar23. WHIPPLEFRANTZ AOVK: Adenoma of islet cells with hyperinsulinism, Ann. Surg., 1935, ci, 1299. CrossrefGoogle Scholar24. WILDERALLENPOWERROBERTSON RMFNMHHE: Carcinoma of the islands of the pancreas, hyperinsulinism and hypoglycemia, Jr. Am. Med. Assoc., 1927, lxxxix, 348. CrossrefGoogle Scholar25. WOMACK NA: Hypoglycemia, Surgery, 1937, ii, 793. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Santa Barbara, California*Received for publication June 18, 1940.From the Divisions of Internal Medicine and Surgery, Sansum Clinic. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byThe Production of Experimental Glycosuria in the RatPAROXYSMAL HYPERINSULINISM DUE TO ISLET ADENOMA OF THE PANCREAS 1 April 1941Volume 14, Issue 10Page: 1915-1932KeywordsAdenomasHyperinsulinemiaHypoglycemiaInsulinSurgery ePublished: 1 December 2008 Issue Published: 1 April 1941 PDF downloadLoading ...