tbuckley/cabot-search huggingface dataset:
Exercise and Osteoarthritis
Authors: Robert D. Bunning, Richard S. Materson
Journal: Annals of Internal Medicine (1992)

Letters15 October 1992Exercise and OsteoarthritisRobert D. Bunning, MD, Richard S. Materson, MDRobert D. Bunning, MDSearch for more papers by this author, Richard S. Materson, MDSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-117-8-697 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the Editors:Dr. Charlson and her colleagues have made an important contribution toward understanding the rational use of exercise for osteoarthritis (1). However, their statement that "sessions included light stretching and strengthening exercises" merits some elaboration. Stretching and strengthening have many descriptors in addition to light (for example, isometric, maximal contraction, passive, and so forth) (2). Furthermore, various types of stretching and strengthening may be effective in arthritis treatment (3, 4) independent of ambulation. Perhaps the authors could elaborate on the nature of the light stretching and strengthening in their study and their relevance to its outcome....References1. Kovar P, Allegrante J, Mackenzie C, Peterson M, Gutin B, and Charlson M. Supervised fitness walking in patients with osteoarthritis of the knee. Annals of Internal Medicine. 1992;116:529-34. LinkGoogle Scholar2. Bunning R and Materson R. A rational program of exercise for patients with osteoarthritis. Semin Arthritis Rheum. 1991;21(Suppl 2):33-43. CrossrefMedlineGoogle Scholar3. Fisher N, Pendergast D, Gresham G, and Calkins F. Muscle rehabilitation: Its effect on muscular and functional performance of patients with knee osteoarthritis. Arch Phys Med Rehabil. 1991;72:367-74. MedlineGoogle Scholar4. Leivseth G, Tortstensson J, and Reikeras O. Effect of passive muscle stretching in osteoarthritis of the hip. Clin Sci. 1988;76:113-7. CrossrefGoogle Scholar1. Daniels L and Worthingham C. Therapeutic Exercise for Body Alignment and Function. 2nd edition. Philadelphia: W.B. Saunders; 1977. Google Scholar2. Fiatarone M, Marks E, Ryan N, Meredith C, Lipsitz L, and Evans W. High-intensity strength training in nonagenarians: effects on skeletal muscle. JAMA. 1990;263:3029-34. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: Robert D. Bunning, MD; Richard S. Materson, MDAffiliations: National Rehabilitation Hospital Washington, DC 20010 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byExercise Is Medicine 15 October 1992Volume 117, Issue 8 Page: 697-698 Keywords Arthritis Exercise Osteoarthritis Walking ePublished: 1 December 2008 Issue Published: 15 October 1992 PDF downloadLoading ...
TRAUMATISMS OF THE MALE URETHRA— WITH REPORTS OF TWO CASES.
Authors: CHARLES W. HITCHCOCK
Journal: JAMA (1899)

To even comment on the wisdom and nicety with which are protected the canals and organs on the integrity of which life itself depends, is almost trite, and nothing more justly elicits such admiration than the anatomic structure and situation of the urinary organs and tract, from the kidney to and including the urethra. Another trite saying, "it never rains but pours," so frequently illustrated in the physician's experience in the successive occurrence of similar cases, was exemplified in my practice recently by twooo cases of traumatic rupture of the male urethra, within two weeks of each other, whereas I shall probably not see another case for years to come since happily, this canal is seldom the site of violent traumatisms, and their seriousness may well be said to be in direct proportion to their rarity. Though I run the risk here of "carrying coals to Newcastle," still it may
A model-free approach to low-dose extrapolation.
Authors: D Krewski, D Gaylor, M Szyszkowicz
Journal: Environmental Health Perspectives (1991)

Estimates of risk associated with exposure to low levels of carcinogenic substances present in the environment are generally obtained by linear extrapolation from higher exposure levels at which risks can be estimated directly. In this paper, we examine the scientific basis for the assumption of low-dose linearity in carcinogenic risk assessment and the different statistical methods that have been proposed for linear extrapolation. A model-free approach to linear extrapolation is described and illustrated using epidemiological data on radiation carcinogenesis. The statistical properties of this method are empirically assessed using 572 selected sets of bioassay data.
Obstetrics and Gynecology: The Clinical Core
Authors: Dave E. David
Journal: JAMA (1988)

<i>Obstetrics and Gynecology: The Clinical Core</i>is an excellent textbook for medical students beginning their medical rotation in obstetrics and gynecology. This book makes an excellent reference as well as the perfect book to read cover to cover before beginning a clinical rotation. Additionally, this would be a superb text for nurses and other clinical personnel beginning careers in the offices of private obstetrician-gynecologists. The book reads very easily and pleasantly and contains numerous black-and-white photomicrographs, enabling the student to better visualize certain pathological entities as well as normal architecture. The book contains numerous "listings" in nontext form for easy perusal, examples being indications for diagnostic ultrasound, the gynecologic and obstetric history, internally ingested drugs' effects on the fetus, and high-lighted points for the gynecologic examination. The book contains areas of fine print within each chapter for more extensive information, which the author intended for use in studying for basic
Robert Francis Patrick Cronin
Authors: Krishna Somers
Journal: BMJ (2007)

Patrick Cronin was the son of A J Cronin, the celebrated writer. His family moved to the United States at the outbreak of the second world war. He was enrolled at Princeton but interrupted his study when he enlisted in the Royal Canadian Air Force in 1943, transferring to the British Army between 1945 and 1947. He re-enrolled at Princeton in 1999 to resume his bachelor of arts degree at Princeton. Having taken 52 …
Glucose transporter-1 protein is immunohistochemically expressed in subglottic infantile haemangioma
Authors: M.G. Liang, S. Maccario, R. Rahbar, H.P.W. Kozakewich, J.B. Mulliken
Journal: British Journal of Dermatology (2008)

Conflicts of interest: none declared. Sir, We read with scepticism the recent report by Purvis et al.1 of negative glucose transporter‐1 protein (GLUT1) immunostaining in 11 of 14 subglottic haemangiomas and only focal positivity in the other three specimens. The authors concluded that subglottic haemangiomas are not the ‘classic’ infantile tumours and are an immunohistochemically distinct entity. They also stated that GLUT1 immunostaining was of limited value in the assessment of subglottic vascular lesions. Why would haemangioma in the trachea not be immunopositive for GLUT1? These subglottic lesions appear at the same time and look the same as cutaneous and submucosal infantile haemangiomas. They also regress in the same fashion. Furthermore, 50% of subglottic haemangiomas are associated with cutaneous lesions. Subglottic haemangiomas also respond to systemic or intralesional corticosteroid, interferon and vincristine. Following internal review board approval, we reviewed seven specimens of subglottic haemangioma taken from infants between 2 and 7 months of age from 1972 to 2007. Specimens were defined as GLUT1‐positive if there was >50% staining of the endothelial cells in lesional microvessels. All seven specimens were GLUT1‐positive.
Genetic Research and Smoking Behavior—Reply
Authors: Chris Carlsten, Wylie Burke
Journal: JAMA (2007)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Prognostic and Therapeutic Implications of Distinct Kinase Expression Patterns in Different Subtypes of Breast Cancer
Authors: Giampaolo Bianchini, Takayuki Iwamoto, Yuan Qi, Charles Coutant, Christine Y. Shiang, Bailang Wang, Libero Santarpia, Vicente Valero, Gabriel N. Hortobagyi, W. Fraser Symmans, Luca Gianni, Lajos Pusztai
Journal: Cancer Research (2010)

Different kinases are expressed in different clinical subsets of breast cancer. In this study, we assessed kinase expression patterns in different clinical subtypes of breast cancer, evaluated the prognostic and predictive values of kinase metagenes, and investigated their functions in vitro. Four hundred twenty-eight protein kinases in gene expression data were examined from 684 cases of breast cancer and 51 breast cancer cell lines to identify kinase expression patterns. We tested the prognostic value of kinase metagenes in 684 node-negative patients who received no adjuvant therapy and the predictive value in 233 patients who received uniform neoadjuvant chemotherapy. Twelve kinases were overexpressed in estrogen receptor (ER)-positive/human epidermal growth factor receptor 2 (HER2)-negative, 7 in HER2(+), and 28 in ER(-)/HER2(-) cancers, respectively. We examined the functional role of 22 kinases overexpressed in ER(-)/HER2(-) cancers using siRNA. Downregulation of these kinases caused significant subtype-specific inhibition of cell growth in vitro. Two robust kinase clusters, including an immune kinase cluster and a mitosis kinase cluster, were present in all clinical subgroups. High mitosis kinase score was associated with worse prognosis but higher pathologic complete response (pCR) in ER(+)/HER2(-) cancers, but not in ER(-)/HER2(-) or HER2(+) cancers, in univariate and multivariate analyses including other genomic predictors (MammaPrint, genomic grade index, and the 76-gene signature). Conversely, higher immune kinase score was associated with better survival in ER(+)/HER2(-) and HER2(+) tumors and also predicted higher probability of pCR in HER2(+) cancers. Taken together, our results indicate that kinases regulating mitosis and immune functions convey distinct prognostic information that varies by clinical subtype.
William J. Harrington, MD
Authors: Bernard J. Fogel
Journal: JAMA (1993)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Severe exacerbation of pemphigus vulgaris in pregnancy: successful treatment with plasma exchange
Authors: J-O. Piontek, H. Borberg, S. Sollberg, T. Krieg, N. Hunzelmann
Journal: British Journal of Dermatology (2000)

Sir, Exacerbation of pemphigus vulgaris in pregnancy is rare (fewer than 30 reported cases) and in previous reports was treated with corticosteroids and the variable addition of immunosuppressive drugs (e.g. azathioprine).1 The outcomes noted in these reports varied from uneventful, with successful completion of the pregnancy, to fetal loss.2,3 The use of plasma exchange for the treatment of pemphigus vulgaris has been reported by several groups4 but to our knowledge its use has not previously been reported in pregnancy. We report a 34‐year‐old woman who presented in the 12th week of pregnancy with a massive exacerbation of pemphigus vulgaris, which had been diagnosed 5 years previously. The disease had been in remission without immunosuppressive therapy during the preceding 2 years. There were multiple erosions of the nasal and oral mucous membranes in addition to disseminated blisters all over her body. The diagnosis was confirmed by histology, direct and indirect immunofluorescence. Because of the severity of disease we decided to start treatment with of oral prednisolone 150 mg daily accompanied by topical therapy (Fig. 1). Subsequently, treatment with plasma exchange was instituted as shown in Fig. 1 in order to remove circulating antibodies rapidly. Treatment was well tolerated and rapid remission of the disease was observed. The first three plasma exchanges were performed on three successive days whereas the following four exchanges were based on the clinical course and antibody titre as determined by indirect immunofluorescence. The plasma was exchanged against 5% human albumin, processing between 120% and 180% of the patient's plasma volume in relation to the fibrinogen titre. The last four treatments exchanged 100% of the patient's plasma volume, and allowed a reduction of the steroid dose after 1 month to 40 mg prednisolone daily, and during the following month to 15 mg daily. Due to placental insufficiency, Caesarean section delivery became necessary in the 34th week of gestation. The newborn (1850 g) was normally developed to gestational age and showed no signs of neonatal pemphigus. The steroid dose was tapered further in the following months with no need for additional immunosuppression.
S100 Change in diastolic pulmonary artery pressure (3 months post surgery compared to pre-surgery value) as a long-term prognostic parameter in patients treated with pulmonary endarterectomy for chronic thromboembolic pulmonary hypertension
Authors: G. C. Hagan, C. Treacy, K. Sheares, D. P. Jenkins, J. PepkeZaba, A. Kacprzak
Journal: Thorax (2010)

<h3>Introduction</h3> The definitive treatment for chronic thromboembolic pulmonary hypertension is pulmonary endarterectomy (PEA). Some patients are left with residual pulmonary hypertension after the surgery. We analysed post-PEA haemodynamics to assess their impact on long-term survival. <h3>Methods</h3> We analysed systolic(sPAP), diastolic(dPAP) and mean(mPAP) pulmonary artery pressures, pulmonary vascular resistance (PVR) and changes (Δ) in these parameters measured at right heart catheterisation from pre-PEA to 3 months post PEA in 251 patients who underwent PEA in our centre in years 2000–2009. We assessed their usefulness as survival predictors using receiver operating characteristic (ROC) curves for 56 patients who completed at least 6 years follow-up. Eight of them died during this period, 48 survived. Subsequently, on the basis of ROC, we identified a cut-off value for change in diastolic pulmonary artery pressure (ΔdPAP), the parameter which had the biggest area under the curve (AUC). We divided the whole study population according to that value and performed Kaplan–Meier survival analysis. <h3>Results</h3> AUCs were as follows: sPAP (0.57), ΔsPAP(0.7), dPAP(0.72), ΔdPAP(0.76), mPAP(0.66), ΔmPAP (0.71), PVR(0.65), ΔPVR(0.73). We chose 24.5 mm Hg as a cut-off value for change in dPAP. It was characterised by 100% specificity and 41.9% sensitivity in predicting death within 6 years post-PEA. Kaplan–Meier survival analysis (with time zero taken at time of right heart catheter 3 months post-PEA) for the whole group showed that patients with ΔdPAP&gt;24.5 mm Hg had significantly better survival rates in comparison to patients with ΔdPAP&lt;24.5 mm Hg (p=0.03)—Abstract S100 Figure 1. 13 of 59 patients with ΔdPAP&gt;24.5 mm Hg still had pulmonary hypertension 3 months post-PEA. The overall 5-year survival of the whole group was 80.8%. <h3>Conclusions</h3> 3 months post-PEA dPAP and ΔdPAP from pre-PEA values appeared to be the best survival predictor. The advantage of utilising dPAP is that it is a directly measured value and less susceptible to error then derived PVR.
Organic dust-induced interleukin-12 production activates T- and natural killer cells
Authors: C. Müller-Suur, K. Larsson, J. Grunewald
Journal: European Respiratory Journal (2002)

Exposure in swine confinement buildings causes intense airway inflammation and lymphocyte activation, as assessed by bronchoalveolar lavage. To further clarify the T-cell activation, the present in vitro study focused on intracellular cytokine production following exposure to organic dust from swine houses. Whole blood from healthy donors was incubated with swine dust, phytohaemagglutinin (positive control) or Roswell Park Memorial Institute 1640 medium (negative control), and the production of intracellular interferon (IFN)-γ, tumour necrosis factor (TNF)-α, interleukin (IL)-4 and IL-12 was analysed by flow cytometry. Cells were double stained for specific cell surface markers on T-cells (CD3+, CD4+, CD8+), natural killer (NK) cells (CD56+CD16+) and monocytes (defined as CD14+ cells). Following 1 h of incubation of whole blood with swine dust, CD14+ cells produced high levels of TNF-α and IL-12, whereas CD3+, CD4+ and CD8+ T-cells and CD56+CD16+ NK cells required a longer incubation time (22 h) to produce IFN-γ and TNF-α. When antibodies that block the IL-12 receptor were added to whole blood incubated with swine dust, NK cell production of IFN-γ was attenuated and CD69 expression on CD3+ cells decreased. In conclusion, this study indicates that swine dust can, at least in part, stimulate phagocytic cells to activate natural killer cells and T-lymphocytes through the production of interleukin-12.
Activated protein C inhibits tissue plasminogen activator–induced brain hemorrhage
Authors: Tong Cheng, Anthony L Petraglia, Zhang Li, Meenakshisundaram Thiyagarajan, Zhihui Zhong, Zhenhua Wu, Dong Liu, Sanjay B Maggirwar, Rashid Deane, José A Fernández, Barbra LaRue, John H Griffin, Michael Chopp, Berislav V Zlokovic
Journal: Nature Medicine (2006)
BMA meeting: Doctors reject calls to boycott clinical commissioning groups
Authors: H. Jaques
Journal: BMJ (2012)

Delegates at the BMA’s annual representatives meeting this week turned down calls for the association to ballot GPs on a boycott of involvement in England’s new clinical commissioning groups (CCGs).

Despite considerable disquiet in the profession about the ways in which the groups will operate, all-out opposition would eliminate any influence that GPs might have in clinical commissioning and hasten the private sector’s involvement in the NHS, the conference heard.

The groups are set to take over full responsibility for commissioning primary and secondary care services in the NHS in England from April 2015, with the help of commissioning support services, many of which are run by commercial organisations.

Louise Irvine, who represents London GPs on the BMA council, said that the …
Evaluation of Thyroid Status-Reply
Authors: Michael F. Slag
Journal: JAMA (1982)

<h3>In Reply.—</h3> Most investigators believe that persons with abnormal thyroid function test results during episodes of nonthyroidal illness are clinically euthyroid.<sup>1</sup>However, the "true" thyroid status during illness is not known because independent assessment is not available (ie, basal metabolic rate, reflex relaxation time, systolic ejection time, and specific liver enzymes are either impractical in clinical application or nonspecific in the presence of other severe medical illness). Thus, we specifically avoided the concept of "true" thyroid status. Given these limitations, it remains important to differentiate persons with diagnosable, nontransient, thyroid illness from the transient state of thyroid hormone alterations in critical illness. We therefore wished to examine several methods of free T4 measurement to determine if the additional information obtained clarified the data available from routine thyroid function tests such as the T4, triiodothyronine resin uptake (T<sub>3</sub>RU), and thyroid-stimulating hormone (TSH). Our data indicated that little additional
Improving Palliative Care
Authors: Diane E. Meier
Journal: Annals of Internal Medicine (1997)

Although most deaths in the United States occur in hospitals, data suggest that hospitals and physicians are not equipped to handle the medical and psychosocial problems of dying patients.In this article, we review the barriers to achieving a peaceful death, including inadequate medical professional education on palliative care, and public and professional uncertainty about the difference between forgoing life-sustaining treatment and active euthanasia, and health professionals' difficulty recognizing when patients are dying and the associated sense that death is a professional failure. Other barriers include fiscal constraints on the length of stay, the number of nurses available to care for dying patients, legal and regulatory constraints on obtaining opioid prescriptions, and a segregated system of hospice care that requires patients to be separated from familiar health care providers and settings in order to receive palliative care at the end of life. Identifying the opportunities that can improve the delivery of palliative care at the end of life is the first step toward developing corrective approaches. Strategies that enhance these opportunities are proposed.
Caustic ulcers caused by cement
Authors: MATTI HANNUKSELA, RAIMO SUHONEN, JAAKKO KARVONEN
Journal: British Journal of Dermatology (1976)

Journal Article Caustic ulcers caused by cement Get access MATTI HANNUKSELA, MATTI HANNUKSELA Departments of Dermatology, University Central Hospital, Helsinki, and University Central Hospital, Oulu, Finland Requests for reprints: Dr M. Hannuksela, Department of Dermatology University Central Hospital, FIN‐90220 Oulu 22 Finland. Search for other works by this author on: Oxford Academic Google Scholar RAIMO SUHONEN, RAIMO SUHONEN Departments of Dermatology, University Central Hospital, Helsinki, and University Central Hospital, Oulu, Finland Search for other works by this author on: Oxford Academic Google Scholar JAAKKO KARVONEN JAAKKO KARVONEN Departments of Dermatology, University Central Hospital, Helsinki, and University Central Hospital, Oulu, Finland Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 95, Issue 5, 1 November 1976, Pages 547–549, https://doi.org/10.1111/j.1365-2133.1976.tb00867.x Published: 01 November 1976