tbuckley/cabot-search huggingface dataset:
Metastatic Prostatic Carcinoma Presenting as Cholangiocarcinoma ("Klatskin Tumor")
Authors: Min-Chun Chen
Journal: Annals of Internal Medicine (1990)

Letters and Corrections1 June 1990Metastatic Prostatic Carcinoma Presenting as Cholangiocarcinoma ("Klatskin Tumor")Min-Chun Chen, MD, MPH, Michael R. Mullane, MDMin-Chun Chen, MD, MPHSearch for more papers by this author, Michael R. Mullane, MDSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-112-11-881_2 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the Editor:The clinical picture of prostatic cancer is sometimes puzzling, partly because of the marked variation in the pattern of dissemination (1). We report a case of metastatic prostatic adenocarcinoma manifesting clinically as a Klatskin tumor. In April 1989, a 77-year-old previously healthy black man presented with a 4-day history of yellow scleral discoloration and passage of dark-colored urine and clay-colored stool. No recurrent abdominal pain, itchy skin, or weight loss was noted. Except for icterus and asymptomatic prostatic enlargement without nodules, the examination was unremarkable. The total bilirubin level was 8.7 mg/dL, with a conjugated bilirubin level...References1. Whitmore W. The natural history of prostatic cancer. Cancer. 1973;32:1104-12. CrossrefMedlineGoogle Scholar2. Moynihan B. Gallstones and Their Surgical Treatment. 2d edition. Philadelphia: W.B. Saunders; 1905:458. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: Min-Chun Chen, MD, MPH; Michael R. Mullane, MDAffiliations: University of Illinois Hospital and Clinics at Chicago Chicago, IL 60612 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byUnlikely debris in the biliary tree: Metastatic prostate cancer masquerading as a Klatskin tumorObstructive jaundice caused by ampullary metastases of an endometrioid adenocarcinoma 1 June 1990Volume 112, Issue 11Page: 881-881KeywordsAbdominal painAdenocarcinomaBilirubinCholangiocarcinomaProstate cancerUrineWeight loss ePublished: 1 December 2008 Issue Published: 1 June 1990 PDF downloadLoading ...
The curability of breast cancer.
Authors: W Duncan, G R Kerr
Journal: BMJ (1976)

The age-correlated survival rates for 982 women treated for localised breast cancer were analysed retrospectively. Analysis by size of the primary cancer showed that those with smaller cancers had a significantly higher survival rate and a significantly reduced probability of dying of cancer. Cured groups of patients were identified for all but those with the smallest tumours--2.0 cm in diameter or smaller. A long period of follow-up (to 25 years) is necessary to establish the presence of a large cured group in such cases.
Phantom Pain following Limb Amputation in a Paraplegic
Authors: Richard F.H. Catchlove
Journal: Psychotherapy and Psychosomatics (1983)

The pain of the phantom limb remains a diagnostic and therapeutic challenge. A case is reported in which a paraplegic patient with full sensory ablation below T<sub>11</sub> experienced phantom limb pain only after actual amputation of one of his legs. This suggests that the cause in this case could only be central in origin. Visual appreciation seems to be an important step in this process.
407 Mutations at position 385 within the hypervariable region 1 (HVR1) of the hepatitis C virus (HCV) are rare and not restricted to patients with cryoglobulinemia
Authors: G. Bianchettin, A. Cividini, M. Casato, G. Merlini, E. Silini, M.U. Mondelli
Journal: Journal of Hepatology (2004)
Current Medical Terminology
Authors: Lester S. King
Journal: JAMA (1966)

Beginning with a modest 346 pages in 1963,<i>CMT</i>grew to 476 pages in 1964. The present third edition approaches the 1,000 mark, but size should not be equated with clumsiness. Drawing on the experience of research scientists, practitioners, educators, and medical students, and using analyses of the key-word-in-context index or computer copy of previous editions, Dr. Gordon and his associates have compiled a reference manual of genuine utility. The number of preferred terms has been increased from approximately 2,400 to 3,000. Each preferred term is listed alphabetically, followed by a "telegraphic" definition, with significant etiologies and manifestations, codes, and related terms. Terms with dual meanings were incorporated or deleted. Other improvements include new sections on abbreviations, preferred terms for the more important surgical techniques, and a glossary of more than 500 supplementary definitions. <i>CMT</i>is definitely "computer oriented," permitting timely revision, and research in the areas of programmed teaching
Anatomy of a Diagnosis
Authors: Harold R. Collard, Michael P. Gruber, Steven E. Weinberger, Sanjay Saint
Journal: New England Journal of Medicine (2003)

A 33-year-old man presented for evaluation of hemoptysis. He had been in his usual state of health until the day of presentation, when he had a transient cough productive of one tablespoon (approximately 15 ml) of bright red blood. He did not have associated chest pain or dyspnea. He reported that he had not had recent weight loss, fever, illness, or trauma and that he did not have a history of bleeding.
TCT-216 Delayed coverage of drug eluting stents after interventional revascularization of chronic total occlusions assessed by optical coherence tomography: the ALSTER-OCT-CTO registry
Authors: Christian H. Heeger, Andreas Busjahn, Laura Hildebrand, Felix Lesche, Maximilian Fenski, Felix Meincke, Karl-Heinz Kuck, Martin W. Bergmann
Journal: Journal of the American College of Cardiology (2014)
INCISING AND SUTURING THE LIVER.A NEW METHOD TO RE-ESTABLISH A CONTINUITY AND FOR THE CONTROL OF HEMORRHAGE.
Authors: JACOB FRANK
Journal: JAMA (1905)

The object of all surgical operations, especially in abdominal work, should be to secure primary union. There is no reason why this principle is not as applicable to the surgery of the liver, providing a proper technic can be employed, so that when the cut liver surfaces are coaptated, the continuity of the organ will be re-established, and complete control of hemorrhage secured. That liver surgery has failed to keep pace with the surgery of other abdominal organs can easily be ascertained on perusing the literature of the subject. The first and principal reason was the fear of hemorrhage, which, according to Kocher, is almost as true to-day as in the time of Theden, 1795. The lack of knowledge of the healing and regenerative power of the organ offers a second explanation. A third, the danger of infection, resulting in peritonitis, and, fourth, cholemia due to the escape of bile
REPORT ON A CASE OF "EPITHELIOMA" INVOLVING TONSIL, FAUCIAL PILLAR, TONGUE AND BUCCAL SURFACE, WITH TREATMENT AND APPARENT CURE.
Authors: S. A. OREN
Journal: JAMA (1901)

The history of the patient is as follows: H. S., a male, aged 73, white, married, father of a family of seven healthy adult children, had always enjoyed good health, and had not been sick enough to call a physician in thirty years; to all intents and purposes he was a healthy, robust, active man. His family history was negative. He formerly used tobacco, but not of late years; was not a total abstainer, though not a drinking man. He denied ever having had a specific lesion. About December, 1899, while in Iowa, I was asked to look at the case. At that time the patient was complaining of a little sore throat, which he was pleased to call "a canker sore." A little white spot was discovered on the left anterior faucial pillar, rather high up, not larger than a pin-head, which I thought a simple ulcer, and so
TCT-552 The Impact of Vascular Access for In-Hospital Major Bleeding in Acute Coronary Syndrome Patients with Moderate- to Very High-Bleeding Risk
Authors: Keun-Ho Park, Myung Ho Jeong, Youngkeun Ahn, Sang Cheol Cho, Jong Hyun Yoo, Hee-Yeol Kim, Keum-Soo Park, Seung-Woon Rha
Journal: Journal of the American College of Cardiology (2012)
Reduced p21, p27 and vitamin D receptor in the nodular hyperplasia in patients with advanced secondary hyperparathyroidism11See Editorial by Dusso on p. 1472.
Authors: Masanori Tokumoto, Kazuhiko Tsuruya, Kyoichi Fukuda, Hidetoshi Kanai, Shoji Kuroki, Hideki Hirakata
Journal: Kidney International (2002)
Comparisons of Hospital Care for Patients With AIDS and Other HIV-Related Conditions
Authors: Dennis P. Andrulis
Journal: JAMA (1992)

To compare utilization and financing of inpatient care for persons with the acquired immunodeficiency syndrome (AIDS) (as defined by the Centers for Disease Control) and those with "other HIV [human immunodeficiency virus]-related illness."A mailed survey of the members of five national organizations representing public, teaching, children's, community, and Catholic hospitals. The survey requested information on demographics, service utilization, costs, and financing of care for AIDS and other HIV patients. Statistical analysis using paired t tests was conducted to evaluate differences between group means for AIDS and other HIV patients. Differences among categorical variables were evaluated by calculation of proportions and compared using chi 2 tests.Five hundred eighteen of 1158 hospitals surveyed responded to the AIDS and other HIV portions of the survey.Three hundred twenty-five hospitals reported treating at least one other HIV patient. These 325 hospitals treated 30% of all AIDS patients (16,213) estimated to have been alive during 1988, and provided care to over 11,000 other HIV patients. Service utilization by other HIV patients was found to comprise a substantial portion of the total HIV burden and related costs, representing 35% of all HIV-related admissions, 29% of all inpatient costs, and 35% of all inpatient losses. Demographic and mode of exposure analysis indicated that other HIV patients were more likely than AIDS patients to be intravenous drug users, female, nonwhite, and to have no source of public or private coverage for their health care.Our results demonstrate that accounting for only the utilization of services by persons with AIDS as defined by the Centers for Disease Control will understate significantly the total burden of the HIV epidemic on hospitals. The results suggest that the expanded definition proposed by the Centers for Disease Control would incorporate a large hospitalized HIV population.
Notch1 Regulates Maturation of CD4+ and CD8+ Thymocytes by Modulating TCR Signal Strength
Authors: David J. Izon, Jennifer A. Punt, Lanwei Xu, Fredrick G. Karnell, David Allman, Peggy S. Myung, Nancy J. Boerth, John C. Pui, Gary A. Koretzky, Warren S. Pear
Journal: Immunity (2001)
VOMITING AND SPINAL ANESTHESIA
Authors: George W. Reese
Journal: JAMA (1933)

<h3>To the Editor:</h3> —At the Shamokin State Hospital we have been using spinal anesthesia for the past four years (procaine hydrochloride); we consider it the ideal method, obstetrics included, below the diaphragm. We have given 2,000 spinal anesthesias without any fatality; but vomiting occurs almost instantly, particularly in appendectomies when either a hemostat or a ligature is put on the meso-appendix. However, we have changed our technic and before we put either a hemostat or a ligature on the meso-appendix we block the nerves in the meso-appendix with 0.5 per cent procaine hydrochloride and find that vomiting does not occur. This, I believe, is due to the following: 1. The autonomic nervous system of Langley, formed by Gaskell's nerves from the anterior horns of the spinal cord to the great sympathetic ganglions, with the vagus and the pelvic nerve, forms the great thoracic and abdominal nerve plexuses and gives the
Transmission of HBsAg from mother to infant in four ethnic groups.
Authors: A Derso, E H Boxall, M J Tarlow, T H Flewett
Journal: BMJ (1978)

Antenatal screening in the West Midlands during a three-year period identified 297 mothers who were chronic carriers of hepatitis B surface antigen (HBsAg)--a prevalence of about 1 in 850. About half of their infants had HBsAg in the cord blood, but of 122 infants followed up for over three months (mean 8.5 months) only 17 (14%) were still positive for HBsAg. Cord-blood HBsAg-positivity was evenly distributed among different ethnic groups, but the transmission rate was highest among the Chinese, and no carriers were discovered among 39 European infants. Raised serum transaminase concentrations were found in some of the carrier infants who were otherwise healthy. The results suggest that adequate follow-up of HBsAg-positive infants may be achieved by tests at 4 months and 1 year of age, and that the role of breast-feeding in mother-to-infant transmission of HBsAg is unimportant. The Chinese community may be a suitable population in which to test the effectiveness of specific immunoglobulin administration at birth in preventing the development of the HBsAg carrier state.
MORE PHYSICIANS AND LESS LAWYERS IN CONGRESS AND LEGISLATURE.
Authors: EPHRAIM CUTTER
Journal: JAMA (1897)

The present number of physicians in the United States Congress is ten. Lawyers are 303, or about 70 per cent. (See Appendix A.) The present is a good time to discuss this, as a department of public health in the President's Cabinet is advocated, and as the Government attends to the biologic needs of plants, cattle, hogs and sheep more than they do to the same needs of human beings. Public health is worth more than coal, gold, houses, lands, silver or wine, although it is unlisted in the census of National wealth. There is need of physicians awaking to a realizing sense of their National rights and importance as citizens, especially in governmental bodies. <h3>Congress and legislatures are representative bodies of the people.</h3> —Professional people alone are not truly represented. The law alone can not represent medicine. There are in the United States some 75,000 lawyers who represent some
DANGERS OF THE IODIN TREATMENT IN EXOPHTHALMIC GOITER
Authors: Torald Sollmann
Journal: JAMA (1924)

To the Editor:  —In view of the recent developments in thyroid therapy, the following extracts from Robley Dunglison's translation of the third edition of Magendie's Formulaire (Philadelphia, 1824), may be of interest as showing the status of iodin therapy a century ago. It will add to the historical setting to recall that iodin was discovered by Courtois in 1813.  M. Coindet, a physician of Geneva, first used iodine in medicine. He employed it in the treatment of goitre with very marked effects. These trials were repeated by several physicians, both in France and Switzerland; and their observations would seem to prove that we now possess, in iodine, an efficacious remedy for the removal of a disease which has been hitherto cured with difficulty.  Although success may be especially expected to follow the use of iodine when the goitre is recent, and has occurred in individuals who have not yet arrived
Toxic Shock Syndrome and the Contraceptive Sponge
Authors: Arthur L. Reingold
Journal: JAMA (1986)

A little over five years ago, following the widespread dissemination of the results of epidemiologic studies linking menstrual toxic shock syndrome (TSS) to the use of tampons, many women switched to other forms of menstrual protection. As a result, the percentage of menstruating women who used tampons fell from 70% to 49%. In addition, the manufacturer of a single brand of tampons withdrew its product from the market after further studies demonstrated that users of that brand were at increased risk of developing menstrual TSS compared with users of other brands. In these studies, the relative risks or odds ratios (the extent to which users of a given product were at increased risk of developing TSS, compared with nonusers) were in the range of 8 to 30. Thus, tampon users in general were approximately 18 times as likely to develop menstrual TSS as nonusers, 1 and users of Rely brand
Left ventricular geometry and function in adults with Ebstein's anomaly of the tricuspid valve.
Authors: L N Benson, J S Child, M Schwaiger, J K Perloff, H R Schelbert
Journal: Circulation (1987)

We postulated that the abnormal shape, size, and function of the right heart and adjoining ventricular septum in adults with Ebstein's anomaly of the tricuspid valve might in turn alter the shape and function of the left ventricle. Seven adult patients with uncomplicated Ebstein's anomaly were studied. Left ventricular geometry was determined by two-dimensional echocardiography. Left ventricular function was assessed by treadmill exercise and radionuclide angiography at rest and with exercise. Paradoxic ventricular septal motion was consistently present. Left ventricular eccentricity (ratio of two minor axes in the short-axis view) was uniformly abnormal, averaging 1.35 +/- 0.23 (normal = 1.02 +/- 0.05). The ratio of right to left ventricular cavity size averaged 1.70 +/- 0.44 (normal 0.65 +/- 0.30), and tricuspid valve displacement into the right ventricular cavity averaged 52% (normal 8%). Functional right atrial size averaged 27.6 +/- 5.2 cm2 (normal right atrial area = 13.1 +/- 2.2 cm2). Resting left ventricular ejection fractions were below 50% in all but two patients. In response to Bruce protocol exercise stress, there were consistently appropriate increments in heart rate, blood pressure, and peak double product and, with one exception, radionuclide left ventricular ejection fraction. There were significant correlations between tricuspid valve displacement and functional right atrial size versus resting left ventricular ejection fraction and left ventricular eccentricity. These data support the hypothesis that derangements in right heart morphology and function in Ebstein's anomaly contribute to significant alterations in left ventricular geometry, but the geometric alterations are associated with tangible but less significant changes in left ventricular systolic function.
Towards an Explanation of Inconsistent Rates of Posttraumatic Stress Disorder across Different Countries: Infant Mortality Rate as a Marker of Social Circumstances and Basic Population Health
Authors: Yutaka Matsuoka, Daisuke Nishi, Naohiro Yonemoto, Satomi Nakajima, Yoshiharu Kim
Journal: Psychotherapy and Psychosomatics (2009)
Amiodarone-associated Proarrhythmic Effects: A Review with Special Reference to Torsade de Pointes Tachycardia
Authors: Stefan H. Hohnloser
Journal: Annals of Internal Medicine (1994)

Purpose: To assess the incidence of amiodarone-mediated aggravation of ventricular tachyarrhythmias or the development of new arrhythmias, such as torsade de pointes, in patients with cardiac disease. Data Sources and Study Selection: A MEDLINE literature search was done to identify articles published during the last 20 years that presented data on amiodarone-associated proarrhythmic events. The articles were divided into three categories: case reports, uncontrolled retrospective studies, and prospective controlled trials. In addition, articles were identified that examined the effects of amiodarone in patients with previously documented drug-induced torsade de pointes. Results: 65 English-language case reports dealing with torsade de pointes during amiodarone therapy were found in the literature. In many of these cases, other predisposing factors for the development of torsade de pointes were reported. Seventeen studies each reported data from at least 50 patients who were treated with amiodarone for at least 6 months. Of 2878 patients included in these trials, 57 were reported to have a proarrhythmic event while exposed to the drug (an overall incidence of 2%). Torsade de pointes was observed in one third of these patients (an overall incidence of 0.7%). In seven placebo-controlled trials in which the drug was given as monotherapy, amiodarone was not associated with the development of a proarrhythmic event in any patient. Finally, in three reports, 31 patients with previous drug-mediated torsade de pointes were exposed to amiodarone during short- and long-term therapy. In none of these patients did a recurrent episode of torsade de pointes develop, despite the amiodarone-induced prolongation of the QTc interval, which was equivalent to that observed at the time of torsade de pointes during exposure to previous drugs. Conclusions: Amiodarone appears to be associated with a remarkably low frequency of proarrhythmic events and an incidence of torsade de pointes of less than 1.0%. This low arrhythmogenicity and the negligible negative inotropic effect of the compound constitute properties that make amiodarone particularly useful in treating high-risk patients prone to sudden cardiac death. Its potential to reduce this risk is currently being evaluated in several large prospective trials.
Child health surveillance lists.
Authors: C Waine
Journal: BMJ (1991)

Child health surveillance lists Doctors should decide criteria for admission to lists and standards ofpractice Many reasons exist why health services for children are best provided by the primary health care team.General practitioners and health visitors have a long tradition of caring for families and visiting them in their homes.The consultation in general practice is the ideal opportunity to offer preventive and therapeutic care.And general practice is based on local communities, accessible to 95% of the population, and cost effective.Recognition of this dates back to the Court report (1976), which advocated that child surveillance should increasingly take place in general practice (rather than in the community services).'Progress towards the two tier delivery recom- mended by Professor Court has, however, been slow.Milestones along the way include Healthier Children-Thinking Prevention,2 which advocated that child surveillance should be part of the core of general practice, and the Handbook of Preventive Care for Pre-school Children.'Later came Health for All Children, containing the views of a working party chaired by Dr David Hall, which looked critically at all aspects of child surveillance and recommended a core programme.4A second edition refining earlier recommendations and defining responsibility will be published soon.