Calcitriol in Prolonged Hypocalcemia due to the Tumor Lysis Syndrome
Authors: Robert W. Dunlay
Journal: Annals of Internal Medicine (1989)

Brief Reports15 January 1989Calcitriol in Prolonged Hypocalcemia due to the Tumor Lysis SyndromeRobert W. Dunlay, MD, Mark A. Camp, MD, Michael Allon, MD, Paolo Fanti, MD, Hartmut H. Malluche, MD, Francisco Llach, MDRobert W. Dunlay, MD, Mark A. Camp, MD, Michael Allon, MD, Paolo Fanti, MD, Hartmut H. Malluche, MD, Francisco Llach, MDAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-110-2-162 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe tumor lysis syndrome is recognized by the development of hyperuricemia, hyperkalemia, hyperphosphatemia, and hypocalcemia shortly after the administration of therapy for neoplastic disorders (1, 2). The syndrome has most often been associated with rapidly dividing hematopoetic malignancies, such as acute leukemias and high-grade lymphomas. Hypocalcemia in the tumor lysis syndrome has been attributed to precipitation of calcium phosphate salts (2), but the reasons it persists after the hyperphosphatemia is corrected have not been elucidated.We report a case of acute tumor lysis syndrome with prolonged hypocalcemia in a patient with Burkitt lymphoma. Serial biochemical measurements during the course of...References1. ZusmanBrownNesbit JDM. Hyperphosphatemia, hyperphosphaturia and hypocalcemia in acute lymphoblastic leukemia. N Engl J Med. 1973;289:1335-40. CrossrefMedlineGoogle Scholar2. CohenBalowMagrathPoplackZiegler LJIDJ. Acute tumor lysis syndrome. A review of 37 patients with Burkitt's lymphoma. Am J Med. 1980;68:486-91. CrossrefMedlineGoogle Scholar3. ReinhardtHorstOrfHollis TRJB. A microassay for 1,25-dihydroxyvitamin D not requiring high performance liquid chromatography: application to clinical studies. J Clin Endocrinol Metab. 1984;58:91-8. CrossrefMedlineGoogle Scholar4. MassrySteinGarty SRJ. Skeletal resistance to the calcemie action of parathyroid hormone in uremia: role of 1,25(OH)2D3. Kidney Int. 1976;9:467-74. CrossrefMedlineGoogle Scholar5. SomervilleKaye PM. Resistance to parathyroid hormone in renal failure: role of vitamin D metabolites. Kidney Int. 1978;14:245-54. CrossrefMedlineGoogle Scholar6. WilsonFelsenfeldDreznerLlach LAMF. Altered divalent ion metabolism in early renal failure: role of 1,25(OH)2D. Kidney Int. 1985;27:565-73. CrossrefMedlineGoogle Scholar7. LlachFelsenfeldHaussler FAM. The pathophysiology of altered calcium metabolism in rhabdomyolysis-induced acute renal failure. Interactions of parathyroid hormone, 25-hydroxycholecalciferol, and 1,25-dihydroxycholecalciferol. New Engl J Med. 1981; 305:117-23. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: From the University of Oklahoma School of Medicine, Oklahoma City, Oklahoma; and the University of Kentucky School of Medicine, Lexington, Kentucky. For current author addresses, see end of text. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByTumor lysis syndromeThe Hypocalcemic DisordersTumor Lysis Syndrome: New Challenges and Recent AdvancesOnco-Nephrology: Tumor Lysis SyndromeThe Hypocalcemic DisordersMetabolic Emergencies in OncologyTumorlysesyndromSupportive Medical Care and Pain Management in Feline Cancer PatientsThe Hypocalcemic Disorders: Differential Diagnosis and Therapeutic Use of Vitamin DPediatric Tumor Lysis SyndromeFLUID AND ELECTROLYTE ABNORMALITIESAcute Spontaneous Tumor Lysis Syndrome in Adenocarcinoma of the LungTumorlysesyndromTumour lysis syndrome, case report and review of the literatureClinical physiology ? pharmacology: multifactorial hypocalcemia in an elderly patient with myeloproliferative disorderTubular causes of renal failureAcute spontaneous tumor lysis syndromeAcute tumor lysis syndrome in patients with high-grade non-Hodgkin's lymphomaTumorlysesyndrom 15 January 1989Volume 110, Issue 2Page: 162-164KeywordsBurkitt lymphomaCalcitriolCalciumCyclic adenosine monophosphateHypocalcemiaLeukemiaLymphomaNephrologyPhosphatesSalts Issue Published: 15 January 1989 PDF DownloadLoading ...