tbuckley/cabot-search huggingface dataset:
Methods for Estimating Glomerular Filtration Rate—Reply
Authors: Caroline S. Fox, Daniel Levy, Bruce Culleton
Journal: JAMA (2004)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Photoprotection in immunocompetent and immunocompromised people
Authors: C. Surber, C. Ulrich, B. Hinrichs, E. Stockfleth
Journal: British Journal of Dermatology (2012)

Ultraviolet radiation (UVR) exposure from the sun and artificial UV sources has been widely acknowledged as the major culprit for skin cancer and premature skin ageing. Skin cancers are among the most dangerous (cutaneous malignant melanoma) and the most numerous (basal cell carcinoma, actinic keratosis and invasive squamous cell carcinoma) of all neoplasms in the caucasian population worldwide. Skin cancers therefore have a significant impact on public health and healthcare costs, and will continue to do so. It is obvious that adequate photoprotection - seeking shade, wearing protective clothing and using sunscreens - is the key to reducing the harmful effects of UVR in both immunocompetent and immunocompromised people. This article provides background information on UVR, photoprotection (including the concept of topical sunscreen formulations), associated concerns regarding efficacy and safety, and behavioural and educational aspects of photoprotection and skin cancer prevention in immunocompetent and immunocompromised people. Certain persistent misconceptions and mistakes regarding photoprotection are also addressed.
Winners and Losers
Authors: Daniel Merenstein
Journal: JAMA (2004)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Abstract 168: Understanding the role of the carcinoid associated fibroblasts in the neuroendocrine tumor microenvironment
Authors: Michaela Bowden, Ewa Sicinska, Matthew Kulke, Massimo Loda
Journal: Cancer Research (2014)

Abstract A lack of cell lines and animal models has been an obstacle in developing novel therapeutic agents for advanced carcinoid tumors. In the past two years we have developed a collection of short-term carcinoid cell lines. Carcinoid cells in culture grow slowly and are importantly attached to, much faster, growing stromal fibroblasts, referred to as CAF's (Carcinoid Associated Fibroblasts). This phenotype is conserved in vivo and closely mimics the status of these tumors in humans. CAF's are known to have pro-tumorigenic effects; are attractive targets for cancer therapy; as well as valuable clinical biomarkers of prognosis. With the availability of an in-house panel of primary cell lines and control cultured fibroblasts, teasing apart the tumor-fibroblast relationship is feasible through collection of cell culture supernatants and in vitro screening of secreted proteins. We present here our initial screening studies using three cell culture environments, namely normal human fibroblasts, carcinoid-associated fibroblasts (CAF's) and the tumor microenvironment co-culture of stromal cells and CAF's. We screened 55 secreted proteins with known carcinogenic associations by multiplexed bead-based (BioPlex, BioRad) analysis. We have identified a potential 5-marker CAF signature encompassing elevated secretion of IL-6 and MCP-1; and the suppression of IL-8 and FGF basic, coupled with VEGF expression. As part of the next phase we plan to utilize our collection of banked whole blood, serum, and plasma specimens comprising over 1000 cases of patients with neuroendocrine tumors, to validate our secreted protein signature in early diagnosis and / or assessing progression and prognosis in patients with neuroendocrine tumors based on stage and tumor subtype. Citation Format: Michaela Bowden, Ewa Sicinska, Matthew Kulke, Massimo Loda. Understanding the role of the carcinoid associated fibroblasts in the neuroendocrine tumor microenvironment. [abstract]. In: Proceedings of the 105th Annual Meeting of the American Association for Cancer Research; 2014 Apr 5-9; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2014;74(19 Suppl):Abstract nr 168. doi:10.1158/1538-7445.AM2014-168
Seroprevalence of human granulocytic anaplasmosis in Berlin Brandenburg, Germany: an 8-year survey
Authors: J. Kowalski, W. Hopfenmïller, V. Fingerle, H. Malberg, M. Eisenblätter, J. Wagner, K. Miksits, H. Hahn, R. Ignatius
Journal: Clinical Microbiology and Infection (2006)
Severe Acute Pancreatitis—Reply
Authors: Vege Santhi Swaroop, Suresh T. Chari, Jonathan E. Clain
Journal: JAMA (2004)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Six-Month versus Twelve-Month Dual Antiplatelet Therapy after Implantation of Drug-Eluting Stents
Authors: Hyeon Cheol Gwon, Joo-Yong Hahn, Kyung Woo Park, Young Bin Song, In-Ho Chae, Do-Sun Lim, Kyoo-Rok Han, Jin-Ho Choi, Seung-Hyuk Choi, Hyun-Jae Kang, Bon-Kwon Koo, Taehoon Ahn, Jung-Han Yoon, Myung-Ho Jeong, Taek-Jong Hong, Woo-Young Chung, Young-Jin Choi, Seung-Ho Hur, Hyuck-Moon Kwon, Dong-Woon Jeon, Byung-Ok Kim, Si-Hoon Park, Nam-Ho Lee, Hui-Kyung Jeon, Yangsoo Jang, Hyo-Soo Kim
Journal: Circulation (2011)

Background —The optimal duration of dual antiplatelet therapy (DAPT) after implantation of drug-eluting coronary stents (DES) remains undetermined. We aimed to test whether 6-month DAPT would be noninferior to 12-month DAPT after implantation of DES. 

Methods and Results —We randomly assigned 1443 patients undergoing implantation of DES to receive 6-month or 12-month DAPT (in a 1:1 ratio). The primary end point was a target vessel failure (TVF) defined as the composite of cardiac death, myocardial infarction, or ischemia-driven target vessel revascularization at 12 months. Rates of TVF at 12 months were 4.8% in the 6-month DAPT group and 4.3%  in the 12-month DAPT group (the upper limit of one-sided 95% confidence interval [CI], 2.4%; P =0.001 for noninferiority with a pre-defined noninferiority margin of 4.0%). Although stent thrombosis tended to occur more frequently in the 6-month DAPT group than in 12-month one (0.9% versus 0.1%; hazard ratio 6.02, 95% CI 0.72-49.96; P =0.10), the risk of death or myocardial infarction did not differ in the 2 groups (2.4% versus 1.9%; hazard ratio 1.21, 95% CI 0.60-2.47; P=0.58). In the prespecified subgroup analysis, TVF occurred more frequently in the 6-month DAPT group than in the 12-month one (hazard ratio 3.16; 95% CI 1.42-7.03; P=0.005) among diabetic patients. 

Conclusions —Six-month DAPT did not increase the risk of TVF at 12 months after implantation of DES compared with 12-month DAPT. However, noninferiority margin was wide, and the study was underpowered for death or myocardial infarction. Our results need to be confirmed in larger trials.
Application of the French guidelines for preventing neonatal group B streptococcal disease in a university hospital
Authors: L. Mereghetti, P. Lanotte, A. Rochoux, A.-S. Sauget, M. Chevillot, F. Perrotin, C. Foller, E. Saliba, R. Quentin, J. Lansac, A. Goudeau
Journal: Clinical Microbiology and Infection (2006)
237. Transgenic Expression of Dp116 in Muscle Does Not Ameliorate Dystrophy in mdx Mice
Authors: Nikola Arsic, Serena Zacchigna, Lorena Zentilin, Genaro Ramirez-Correa, Alessandro Salvi, Gianfranco Sinagra, Mauro Giacca
Journal: Molecular Therapy (2004)

Top of pageAbstract
Vascular endothelial growth factor (VEGF) is a major regulator of blood vessel formation during development and in the adult organism. Recent evidence indicates that this factor also plays an important role in sustaining the proliferation and differentiation of progenitor cells of different tissues, including bone marrow, bone, and the central nervous system. Here we show that the delivery of the 165 aa isoform of VEGF-A cDNA using an adeno-associated virus (AAV) vector exerts a powerful effect on the promotion of myogenic precursor cells differentiation to form multinucleated myotubes in vitro, as well as in the enhancement of muscle regeneration in vivo.

By immunofluorescence staining, we observerved that both VEGFR-1 and VEGFR1-2 are highly expressed during myofiber formation in vitro, and that their expression persists until the late stages of the differentiation process. Receptor expression was concomitant with a pro-fusogenic effect of recombinant VEGF and with the protection of myogenic cells from apoptosis. These activities were most likely mediated by VEGFR-2, since the drug SU-1498, a specific inhibitor of this receptor, completely abolished the effects of VEGF.

Following different types of skeletal muscle damage in mice (resection of the femoral artery or injection of glycerol or cardiotoxin), the delivery of AAV-VEGF markedly improved muscle fiber reconstitution in a dose-dependent manner. This activity was better exerted when the vector was administered 5 days after damage, rather than before, thus clearly indicating that the activity of VEGF most likely exerted on the muscle fibers independently of its well-known pro-angiogenic effects.

In a consistent manner, the expression of both VEGFR-1 and VEGFR-2 was found up-regulated in the satellite cells of the muscles regenerating after damage. The effect of VEGF in vivo appeared to be mediated by VEGFR-2, since the transfer of PlGF, a VEGF family member selectively interacting with VEGFR-1, was ineffective. These results are consistent with the observation that VEGF promotes the growth of myogenic fibers and protects myogenic cells from apoptosis in vitro, and prompt a therapeutic use of VEGF gene transfer in a variety of muscular disorders.
Recent advances: Sexually transmitted infections
Authors: C. Carne
Journal: BMJ (1998)

Sexually transmitted infections are an important cause of morbidity and mortality throughout the world. Over 300 000 cases of sexually transmitted infection were diagnosed in genitourinary medicine clinics in England in 1996.1 Among these infections, the commonest were genital warts (over 50 000 first attacks), non-specific genital infection (over 50 000 cases), proved chlamydial infection (over 30 000 cases), genital herpes (about 15 000 first attacks), and gonorrhoea (over 10 000 cases). In selecting material for this article, I used the current publications section of the journal Sexually Transmitted Infections (formerly Genitourinary Medicine ) and searched Medline under the following headings: Chlamydia trachomatis , human papillomavirus, genital herpes, famciclovir, and valaciclovir. Rates of infection with gonorrhoea in England had been declining rapidly, even before the government launched its Health of the Nation initiative in 1992.2 Unfortunately, soon after the target (a fall in gonorrhoea rates of at least 20% by 1995) had been reached, the trend was reversed: diagnoses of gonorrhoea in genitourinary medicine clinics rose by 20% between 1995 and 1996.1 Over the same period, diagnoses of genital infection with C trachomatis rose by 11% and those of genital warts by 5%.1 Among homosexual men, there was a steady increase in the incidence of genital warts between 1990 and 1995, while there was no clear trend in the incidence of gonorrhoea (fig 1). #### Recent advances
A humanized model for multiple sclerosis using HLA-DR2 and a human T-cell receptor
Authors: Lars S. Madsen, Ellen Christina Andersson, Liselotte Jansson, Michelle Krogsgaard, Claus B. Andersen, Jan Engberg, Jack L. Strominger, Arne Svejgaard, Jens Peter Hjorth, Rikard Holmdahl, Kai W. Wucherpfennig, Lars Fugger
Journal: Nature Genetics (1999)
The determinants of periorbital skin ageing in participants of a melanoma case–control study in the U.K.
Authors: M. Suppa, F. Elliott, J.S. Mikeljevic, Y. Mukasa, M. Chan, S. Leake, B. Karpavicius, S. Haynes, E. Bakker, K. Peris, J.H. Barrett, D.T. Bishop, J.A. Newton Bishop
Journal: British Journal of Dermatology (2011)

Skin ageing is said to be caused by multiple factors. The relationship with sun exposure is of particular interest because the detrimental cutaneous effects of the sun may be a strong motivator to sun protection. We report a study of skin ageing in participants of an epidemiological study of melanoma.To determine the predictors of periorbital cutaneous ageing and whether it could be used as an objective marker of sun exposure.Photographs of the periorbital skin in 1341 participants were graded for wrinkles, degree of vascularity and blotchy pigmentation and the resultant data assessed in relation to reported sun exposure, sunscreen use, body mass index (BMI), smoking and the melanocortin 1 receptor (MC1R) gene status. Data were analysed using proportional odds regression.Wrinkling was associated with age and heavy smoking. Use of higher sun-protection factor sunscreen was protective (P = 0·01). Age, male sex, MC1R variants ('r', P=0·01; 'R', P=0·02), higher reported daily sun exposure (P=0·02), increased BMI (P=0·01) and smoking (P=0·02) were risk factors for hypervascularity. Blotchy pigmentation was associated with age, male sex, higher education and higher weekday sun exposure (P=0·03). More frequent sunscreen use (P=0·02) and MC1R variants ('r', P=0·03; 'R', P=0·001) were protective.Periorbital wrinkling is a poor biomarker of reported sun exposure. Vascularity is a better biomarker as is blotchy pigmentation, the latter in darker-skinned individuals. In summary, male sex, sun exposure, smoking, obesity and MC1R variants were associated with measures of cutaneous ageing. Sunscreen use showed some evidence of being protective.
Access to Trauma Centers—Reply
Authors: Charles C. Branas, Ellen J. MacKenzie, Justin C. Williams, C. William Schwab
Journal: JAMA (2005)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Thalidomide produces benefits in some patients with tumours
Authors: Scott Gottlieb
Journal: BMJ (2001)

The drug thalidomide, which led to severe birth defects in the 1950s when it was used during pregnancy to prevent morning sickness, has been shown to produce benefits in patients with myelodysplastic syndrome and to prevent the progression of some forms of myeloma, according to two separate studies.

Despite its reputation, the drug is gaining favour in the treatment of a variety of cancers and infectious diseases. In one study, Dr Azra Raza, from Rush-Presbyterian-St …
Functional Assessment of Mitral Regurgitation by Transthoracic Echocardiography Using Standardized Imaging Planes
Authors: Jean-Luc Monin, Patrick Dehant, Cécile Roiron, Mehran Monchi, Jean-Yves Tabet, Philippe Clerc, Guy Fernandez, Rémi Houel, Jérome Garot, Christophe Chauvel, Pascal Gueret
Journal: Journal of the American College of Cardiology (2005)
History of Tuberculosis and Drug Resistance
Authors: Giovanni Sotgiu, Antonio Spanevello, Giovanni B Migliori
Journal: New England Journal of Medicine (2013)

n engl j med 368;1 nejm.org january 3, 2013 88 2. Redelmeier DA, Stanbrook MB. Graduated drivers’ licences for seniors: reclaiming one benefit of being young. CMAJ 2012; 184:1123. 3. Stutts J, Wilkins J. Driver licensing policies and practices: gearing up for an aging population. Washington, DC: AAA Foundation for Traffic Safety, 2009 (http://lpp.seniordrivers.org/ lpp/pdf/DriverLicensePoliciesReport.pdf). 4. Redelmeier DA, Yarnell CJ. Lethal misconceptions: interpretation and bias in studies of traffic deaths. J Clin Epidemiol 2012;65:467-73. 5. Stang A, Poole C, Bender R. Common problems related to the use of number needed to treat. J Clin Epidemiol 2010;63:820-5.
The association between filaggrin mutations, hand eczema and contact dermatitis: a clear picture is emerging
Authors: J.P. Thyssen
Journal: British Journal of Dermatology (2012)

Conflicts of interest None declared. ORIGINAL ARTICLE, p 1302 Filaggrin molecules and their metabolites are crucial for skin barrier functions as they organize the keratin filaments and maintain skin hydration. Loss‐of‐function mutations in the filaggrin gene (FLG) affect about 10% of people of European descent, resulting in lower levels of filaggrin and its metabolites.1, 2 Hence, the skin of heterozygous mutation carriers is in many ways fundamentally different from normal skin, showing xerosis, scales, keratosis pilaris and palmar hyperlinearity, the hallmarks of ichthyosis vulgaris. FLG mutation carriers have a higher risk of atopic dermatitis, asthma, rhinitis and food allergies presumably due to increased skin penetration of allergens.3 As filaggrin molecules are metabolized to their constituent amino acids when the relative humidity drops to below 80%,4,FLG mutation carriers display reduced synthesis of the osmolytic ‘natural moisturizing factor’ intended to protect the skin from drying. Based on clinical observations, it has therefore become apparent that FLG mutation carriers are prone to develop inflammation mainly on the dorsal aspects of the fingers and hands,5 sites that are exposed to environmental insults, e.g. sun and wind. Also, FLG mutation carriers develop digital fissures (chapping) more often than those who do not carry the mutation.6
Autoimmune progesterone dermatitis: treatment with oophorectomy
Authors: None RÓdenas, None Herranz, None Tercedor
Journal: British Journal of Dermatology (1998)

Journal Article Autoimmune progesterone dermatitis: treatment with oophorectomy Get access J.M. RÓdenas, J.M. RÓdenas Department of Dermatology, Hospital General Universitario Morales Meseguer, Av. Marqués de los Vélez, 30008 Murcia, Spain, Search for other works by this author on: Oxford Academic Google Scholar M.T. Herranz, M.T. Herranz Department of Internal Medicine, Hospital General Universitario Morales Meseguer, Av. Marqués de los Vélez, 30008 Murcia, Spain, Search for other works by this author on: Oxford Academic Google Scholar J. Tercedor J. Tercedor Department of Dermatology, Hospital Virgen de las Nieves, 18014 Granada, Spain Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 139, Issue 3, 1 September 1998, Pages 508–511, https://doi.org/10.1046/j.1365-2133.1998.02420.x Published: 01 September 1998
What has consciousness to do with explicit representations and stable activation vectors?
Authors: J. Uuml, Rgen Schr Ouml, der
Journal: Behavioral and Brain Sciences (1999)

To assess O'Brien &amp; Opie's connectionist vehicle theory of consciousness, (1) it is not enough to point to the methodological weakness of certain experiments (dichotic listening, etc.). Successful cognitive theories postulating explicit unconscious representations have to be taken into account as well. (2) The distinction between vehicle and process theories cannot be drawn in the way envisaged by the authors because a representation's explicitness depends not only on its structural but also on its processing properties. (3) The stability of an activation vector is not very suitable for implementing the explicitness of a representation.