MYXEDEMA IN TWO BROTHERS, ONE WITH PSYCHOSIS
Authors: W N CHAMBERS, J MILNE
Journal: Annals of Internal Medicine (1955)

Case Reports1 October 1955MYXEDEMA IN TWO BROTHERS, ONE WITH PSYCHOSISWILLIAM N. CHAMBERS, M.D., F.A.C.P., JOHN MILNE, M.D., F.A.C.P.WILLIAM N. CHAMBERS, M.D., F.A.C.P.Search for more papers by this author, JOHN MILNE, M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-43-4-892 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptINTRODUCTIONMyxedema is uncommon in young males and its occurrence in siblings is rare. It is a common but frequently unrecognized cause of organic psychosis.Nearly half the patients cited by the Committee on Myxoedema1had some form of mental disturbance. The psychotic manifestations of myxedema may exhibit themselves before the classic picture of the disease has developed and may be the first obvious evidence of altered thyroid function.2The psychosis which is dependent on myxedema occurs in 15% of patients, usually when the myxedema is advanced.3This psychosis does not represent any specific type, but there is common behavior...Bibliography1. Report of the Committee of the Clinical Society of London to Investigate the Subject of Myxoedema, Tr. Clin. Soc. London 21: Supplement, 1888. Google Scholar2. Means JH: The thyroid and its diseases, 2nd Ed., 1948, J. B. Lippincott Co., Philadelphia, p. 270. Google Scholar3. Akelaitis AJ: Psychiatric aspects of myxedema, J. Nerv. and Ment. Dis. 83: 22 (Jan.) 1936. CrossrefGoogle Scholar4. Asher R: Myxoedematous madness, Brit. M. J. 2: 555-562 (Sept. 10) 1949. CrossrefMedlineGoogle Scholar5. Crowley RM: Psychoses with myxedema, Am. J. Psychiat. 96: 1105-1116, 1940. CrossrefGoogle Scholar6. Bohan PT: A case of ligneous thyroiditis associated with high-grade dental infection, M. Clin. North America 7: 1069, 1924. Google Scholar7. PedigoAbramson GWW: Struma lymphomatosa, Ann. Int. Med. 27: 627, 1947. LinkGoogle Scholar8. McCarrison R: Struma lymphomatosa, Brit. M. J. 1: 5, 1929. CrossrefMedlineGoogle Scholar9. Hellwig CA: Lymphadenoid goiter, Arch. Path. 25: 839, 1938. Google Scholar10. Joll CA: Pathology, diagnosis and treatment of Hashimoto's disease (struma lymphomatosa), Brit. J. Surg. 27: 351, 1939. CrossrefGoogle Scholar11. Womack NA: Thyroiditis, Surgery 16: 770, 1944. Google Scholar12. MarshallMeissnerSmith SFWADC: Chronic thyroiditis, New England J. Med. 238: 758, 1948. CrossrefMedlineGoogle Scholar13. Crile G: Thyroiditis, Ann. Int. Med. 37: 519, 1952. LinkGoogle Scholar14. Barr DP: Thyroiditis and myxedema, Bull. New York Acad. Med. 29: 551-569, 1953. MedlineGoogle Scholar15. Werner SC: Pituitary thyroid relationship in normal and disordered thyroid states, Bull. New York Acad. Med. 29: 523-536 (July) 1953. MedlineGoogle Scholar16. SofferGabriloveJailer LJJLJW: Role of the adrenal in uptake of I131 by the thyroid following parenteral administration of epinephrine, Proc. Soc. Exper. Biol. and Med. 71: 117-119, 1949. CrossrefMedlineGoogle Scholar17. PaschkisEpsteinCantarowFriedler KEDAG: Influence of adrenal hormones on thyroid function in the hypophysectomized rat (abstract), J. Clin. Endocrinol. 12: 939, 1952. Google Scholar18. Greer MA: The role of the hypothalamus in the control of thyroid function, Tr. Am. Goiter A. 207-217, 1952. Google Scholar19. HetzelHinkle BLE: Unpublished observations. (See Wolff, H. G.: Stress and disease, 1953, Charles C Thomas, Springfield, Illinois, p. 111.) Google Scholar20. Alexander A: Myxödem als Kriegsdienstneschädigung, Med. Klin. 13: 994-996, 1917. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Hanover, New Hampshire*Received for publication July 30, 1954.From the Department of Medicine, Hitchcock Clinic, Hanover, New Hampshire.†This study was supported by a grant from the Hitchcock Foundation. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byHypothyroidism: Does Treatment Cure Dementia?REVERSIBLE PSYCHOSIS AND DEMENTIA IN MYXEDEMANeurologic Manifestations of Myxedema 1 October 1955Volume 43, Issue 4Page: 892-903KeywordsBehaviorEmotionsPathogenesisThyroid Issue Published: 1 October 1955 PDF downloadLoading ...