HEPATOMEGALY AND DIABETES MELLITUS
Authors: J I GOODMAN
Journal: Annals of Internal Medicine (1953)

Article1 November 1953HEPATOMEGALY AND DIABETES MELLITUSJOSEPH I. GOODMAN, M.D., F.A.C.P.JOSEPH I. GOODMAN, M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-39-5-1077 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptIt was fully recognized in the older literature that the liver is frequently increased in size, and sometimes tender, in patients with diabetes mellitus.1-3In fact, in 1885 Pavy4found liver enlargement associated with diabetes often enough to warrant his postulating a connection between the two conditions. However, in the recent clinical literature there have been relatively few references to hepatic enlargement in diabetes mellitus.5-7, 14, 18, 32, 36Of more pertinent value in this respect are the reports of animal experiments. Following total extirpation of the pancreas in dogs the liver remains large out of all proportion to the...Bibliography1. Lepine JR: Le Diabète Sucré, 1909, Felix, Paris, pp. 488-90. Google Scholar2. von Noorden DN: Die Zuckerkrankheit und ihre Behandlung, 6th Ed., 1912, Hirschwald, Berlin, p. 194. Google Scholar3. Hirschfeld F: Weitere Beiträge zur Aetiologie des Diabetes, Berl. klin. Wchnschr. 49: 198-204, 1912. Google Scholar4. Pavy FW: Introductory address to the Discussion on the Clinical Aspect of Glycosuria, Lancet 2: 1085-1087 (Dec. 12) 1885. CrossrefGoogle Scholar5. PetersVan Slyke JPDD: Quantitative clinical chemistry, Vol. I, 1946, Williams and Wilkins, Baltimore. Google Scholar6. Thosteson GC: Trends in diabetes mellitus, J. Michigan M. Soc. 46: 924-929 (Aug.) 1947. MedlineGoogle Scholar7. Goodman JI: The enlarged liver in diabetes mellitus: its determination by percussion, Am. J. Digest. Dis. 18: 181-185 (June) 1951. CrossrefMedlineGoogle Scholar8. Sandmeyer W: Ueber die Folgen der Pankreasexstirpation beim Hund, Ztschr. f. Biol. 29: 86-114, 1892; Ueber die Folgen der partiellen Pankreasexstirpation beim Hund, Ztschr. f. Biol. 31: 12-85, 1895. Google Scholar9. Pflüger E: Das Glykogen, und seine Beziehungen zur Zuckerkrankheit, 2 aufl., Bonn. Hager., p. 495, 1905; Untersuchungen über den Pankreasdiabetes, Pflüger's Arch. f. d. ges. Physiol. 118: 265-321, 1907. Google Scholar10. Goodman JI: The diabetic neuropathies, American Lecture Series, 1953, Thomas, Springfield, Ill. Google Scholar11. NewburghConn LHJW: A new interpretation of hyperglycemia in obese middle aged persons, J. A. M. A.: 112: 7-10, 1939; Newburgh, L. H.: Control of the hyperglycemia of obese "diabetics" by weight reduction, Ann. Int. Med. 17: 935-942, 1942. CrossrefGoogle Scholar12. MeringMinkowski JO: Diabetes mellitus nach Pankreasexstirpation, Arch. f. exper. Path. u. Pharmakol. 26: 371-387, 1889. CrossrefGoogle Scholar13. AllenBowieMacLeodRobinson FNDJJJWL: Behaviour of depancreatized dogs kept alive with insulin, Brit. J. Exper. Path. 5: 75-83, 1924. Google Scholar14. MarbleWhiteBoganSmith APIKRM: Enlargement of the liver in diabetic children: its incidence, etiology and nature, Arch. Int. Med. 62: 740-750, 1938. CrossrefGoogle Scholar15. Wilder RM: Clinical diabetes mellitus and hyperinsulinism, 1940, W. B. Saunders Co., Philadelphia. Google Scholar16. ChaikoffGibbsHoltomReichert ILGEGFFL: The lipid metabolism of the hypophysectomized dog and the lipid and carbohydrate metabolism of the hypophysectomized-depancreatized dog, Am. J. Physiol. 116: 543-549 (Aug.) 1936. CrossrefGoogle Scholar17. Connor CL: Fatty infiltration of the liver and the development of cirrhosis in diabetes and chronic alcoholism, Am. J. Path. 14: 347-364 (May) 1938. MedlineGoogle Scholar18. White P: Diabetes in childhood and adolescence, 1932, Lea and Febiger, Philadelphia. Google Scholar19. LeevyRyanFineberg CMCMJC: Diabetes mellitus and liver dysfunction; etiologic and therapeutic considerations, Am. J. Med. 8: 290-299 (Mar.) 1950. CrossrefMedlineGoogle Scholar20. Bohan EM: Diabetes mellitus and cirrhosis of the liver; a case report, Delaware State M. J. 19: 212 (Nov.) 1947. MedlineGoogle Scholar21. Schleusner : Ueber die Zusammenhange zwischen Diabetes mellitus und Erkrankungen der Leber und der Gallenwege, 1938, Herman Bauer, Marburg-Lahn. Google Scholar22. Lewis WH: Gray's Anatomy, 23rd Ed., 1936, Lea and Febiger, Philadelphia, p. 1176. Google Scholar23. Joslin EP: The treatment of diabetes mellitus, 8th Ed., 1946, Lea and Febiger, Philadelphia. Google Scholar24. Foxwell A: Alcoholic cirrhosis of the liver, Brit. M. J. 1: 393-395 (Feb. 15) 1896. CrossrefMedlineGoogle Scholar25. RatnoffPatek ODAJ: The natural history of Laennec's cirrhosis of the liver: an analysis of 386 cases, Medicine 21: 207-268 (Sept.) 1942. CrossrefGoogle Scholar26. Eppinger H: Leberzirrhose vom Standpunkte des Internisten, Arch. f. Verdauungskr. 36: 143-144, 1926. Google Scholar27. Lichtman SS: Diseases of the liver, gallbladder and bile ducts, 1942, Lea and Febiger, Philadelphia, pp. 213-215. Google Scholar28. Zelman S: Liver and spleen visualization by a simple roentgen contrast method, Ann. Int. Med. 34: 466-478 (Feb.) 1951. LinkGoogle Scholar29. ReinbergLipson MHM: The association of Laennec's cirrhosis with diabetes mellitus, Ann. Int. Med. 33: 1195-1202 (Nov.) 1950. LinkGoogle Scholar30. GrayHookBatty SJWJL: Liver function studies in diabetes mellitus, Ann. Int. Med. 24: 72-79 (Jan.) 1946. LinkGoogle Scholar31. AllenLisa FMJR: "Scottie"—twelve years diabetic, Endocrinology 46: 282-290 (Mar.) 1950. CrossrefMedlineGoogle Scholar32. Joslin EP: Treatment of diabetes, 4th Ed., 1928, Lea and Febiger, Philadelphia. Google Scholar33. Allan FN: Diabetic acidosis and leukocytosis, Am. J. M. Sc. 174: 506-510 (Oct.) 1927. Google Scholar34. Allen FM: Encyclopedia of medicine, Vol. 4, 1932, F. A. Davis, Philadelphia, p. 516. Google Scholar35. McKittrick LS: Abdominal symptoms with or without abdominal lesions in diabetic acidosis, New England J. Med. 209: 1033-1036 (Nov. 23) 1933. CrossrefGoogle Scholar36. Beardwood JT: The abdominal symptomatology of diabetic acidosis, J. A. M. A. 105: 1168-1172 (Oct. 12) 1935. CrossrefGoogle Scholar37. BotheBeardwood FAJR: The evaluation of abdominal symptoms in the diabetic, Ann. Surg. 105: 516-520 (Apr.) 1937. CrossrefMedlineGoogle Scholar38. BasslerPeters AAG: Diabetic indigestion, Ann. Int. Med. 30: 740-744 (Apr.) 1949. LinkGoogle Scholar39. Hanssen P: Enlargement of the liver in diabetes mellitus, J. A. M. A. 106: 914-916, 1936. CrossrefGoogle Scholar40. Warren S: The pathology of diabetes mellitus, 1938, Lea and Febiger, Philadelphia, p. 82. Google Scholar41. Rabinowitch JM: Note on the bilirubin content of blood and urobilinogen content of urine in diabetes mellitus, Brit. J. Exper. Path. 17: 249-251, 1936. Google Scholar42. Diamond JS: The value of routine estimations of blood bilirubin: with a report of 567 cases including a group of unrecognized toxic hepatitis, Am. J. M. Sc. 176: 321-331 (Sept.) 1928. CrossrefGoogle Scholar43. Meyer EL: Function of liver in diabetes mellitus, Arch. Int. Med. 47: 182-195, 1931. CrossrefGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Cleveland Heights, Ohio*Received for publication April 29, 1953. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byBeneficial effects of voluntary wheel running on activity rhythms, metabolic state, and affect in a diurnal model of circadian disruptionN-acetyl-L-cysteine ameliorates hepatocyte pyroptosis of dog type 1 diabetes mellitus via suppression of NLRP3/NF-κB pathwaySpectrum of diabetic lesions: An autopsy studyPrevalence of hepatopathy in type 1 diabetic childrenAttenuation of Fatty Liver and Prevention of Hypercholesterolemia by Extract of Curcuma longa through Regulating the Expression of CYP7A1, LDL-Receptor, HO-1, and HMG-CoA ReductaseProlonged Inhibition of Glycogen Phosphorylase in Livers of Zucker Diabetic Fatty Rats Models Human Glycogen Storage DiseasesRapid Onset of Glycogen Storage Hepatomegaly in a Type-2 Diabetic Patient after a Massive Dose of Long-acting Insulin and Large Doses of GlucoseA Case of Hepatic Glycogenosis in a Patient with Uncontrolled Type 1 Diabetes MellitusIntermittent and recurrent hepatomegaly due to glycogen storage in a patient with type 1 diabetes: Genetic analysis of the liver glycogen phosphorylase gene (PYGL)Non-alcoholic fatty liver disease: a brief reviewLeberveränderungen im Verbund mit anderen ErkrankungenHepatomegaly and Abnormal Liver Tests Due to Glycogenosis in Adults with DiabetesMauriac syndrome in childhood diabetesStunted growth and hepatomegaly in diabetes mellitusDie Leber beim menschlichen DiabetesObservations on the structure and function of liver in indian diabeticsRecurrent Hepatomegaly and Transient Alteration of Liver Functions in an Adolescent with Diabetic AcidosisDisturbances in Carbohydrate Metabolism: Liver DiseaseGlycogen-laden hepatomegaly in diabetesThe occurrence of peripheral edema and subcutaneous glycogen deposition following the initial treatment of diabetes mellitus in childrenMarked Enlargement of the Liver and Transient Ascites Associated with the Treatment of Diabetic AcidosisRoentgen and Autopsy Evaluation of Percussion of the Liver and SpleenDiabetes Mellitus and Liver FunctionREFERENCESTHE TEMPORAL-LOBE EPILEPSIESDIABETIC HEPATOMEGALY 1 November 1953Volume 39, Issue 5Page: 1077-1087KeywordsDiabetes mellitusHepatomegalyLiverPancreas ePublished: 1 December 2008 Issue Published: 1 November 1953 PDF downloadLoading ...