tbuckley/cabot-search huggingface dataset:
Transplacental Effects of 1-Ethyl-1-Nitrosourea in Inbred Strains of Mice. IV. Rapid Tumor Induction in Strain Crosses2
Authors: Bhalchandra A. Diwan, Hans Meier, Robert J. Huebner
Journal: JNCI Journal of the National Cancer Institute (1974)

Reciprocal F1 hybrids of AKR/J and SWR/J mice were exposed to transplacental treatment with 1ethyl-1-nitrosourea on day 16 of gestation. (SWR/J ♀ × AKR/J ♀) F1 offspring developed a high incidence both of leukemia (79%) and pulmonary adenomas (93%) in 10 weeks or less. In (AKR/J ♀ × SWR/J ♂)F1 mice, the incidence of lung tumors was lower (50%), and the tumors occurred much later in life, i.e., 16–20 weeks. Thus maternal effect on the development of lung tumors was pronounced. Although the incidence of leukemia was increased (86%) in (AKR/J ♀ × SWR/J ♂)F1 mice, its development was again delayed compared to the (SWR/J ♀ × AKR/J ♂)F1 offspring. No sex difference was observed in the incidence of lung tumors or leukemia in either group of F1 hybrids. Spleens and lung tumors of both crosses were positive for both type-C RNA tumor virus and its group-specific antigen.
Treatment of children with progressive or recurrent brain tumors with carboplatin or iproplatin: a Pediatric Oncology Group randomized phase II study.
Authors: H S Friedman, J P Krischer, P Burger, W J Oakes, B Hockenberger, M D Weiner, J M Falletta, D Norris, A H Ragab, D H Mahoney
Journal: Journal of Clinical Oncology (1992)

PURPOSE The Pediatric Oncology Group (POG) conducted a randomized phase II study to evaluate the activity of carboplatin and iproplatin in children with progressive or recurrent brain tumors. PATIENTS AND METHODS The study was designed to evaluate the activity of these agents and to compare the toxicities associated with their use. Treatment consisted of carboplatin 560 mg/m2 at 4-week intervals or iproplatin 270 mg/m2 at 3-week intervals. RESULTS The major toxicity observed was myelosuppression, particularly thrombocytopenia, for both agents. Ototoxicity (grade 1 or 2) was seen in 2.5% of patients treated with carboplatin and 1.3% of patients treated with iproplatin. The majority of patients with low-grade astrocytic neoplasms treated with carboplatin (nine of 12 patients) or iproplatin (eight of 12 patients) demonstrated tumor response or prolonged stable disease that persisted off-therapy. The duration of stable disease produced by carboplatin was particularly striking, ranging from 2 months to 68 + months (median, 40 + months). Neither drug demonstrated appreciable activity in the treatment of medulloblastoma (two of 26 responses to carboplatin, one of 14 responses to iproplatin), ependymoma (two of 17 responses to carboplatin, none of seven responses to iproplatin), high-grade glioma (two of 19 responses to carboplatin, one of 14 responses to iproplatin), or brain-stem tumors (one of 23 responses to carboplatin, none of 14 responses to iproplatin). CONCLUSION Carboplatin is active against low-grade gliomas. Further evaluation of the role of carboplatin in the preirradiation treatment of children with low-grade gliomas of the optic pathway is currently underway in a clinical trial.
Mouse Lymphoid Leukemias: Symbiotic Complexes of Neoplastic Lymphocytes and Their Microenvironments&lt;xref ref-type="fn" rid="fn2"&gt;2&lt;/xref&gt;
Authors: H Hiai, Y Nishi, T Miyazawa, Y Matsudaira, Y Nishizuka
Journal: JNCI Journal of the National Cancer Institute (1981)

Of 17 primary lymphoid leukemias of the mouse, 15 symbiotic cell lines were isolated by the explantation of leukemia tissues from which free leukemia cells had been mechanically removed. In vitro survival and growth of symbiotic leukemia cells depended on close association with the adherent cells from the initial explants or other sources. Pseudo-emperipolesis was a remarkable morphologic manifestation of symbiosis common to all cell lines, i.e., the leukemia cells were beneath the adherent cells in close contact. Cell interaction in symbiotic leukemias was studied with a representative symbiotic leukemia AKRL-3 and a cell line B6TE-A from normal thymic epithelium. Failure of the culture supernatant of the adherent cells to support the growth of leukemia cells indicated that the function of the adherent cells was mediated by close cell contact. During the culture, many symbiotic cell lines changed growth patterns and eventually grew independently. Consistent isolation of symbiotic cell lines from most primary leukemias, as well as consideration of the role of the thymus in leukemogenesis, may indicate that the lymphoid leukemias are basically symbiotic complexes of neoplastic lymphocytes and their microenvironments in their natural history. Similar lymphoepithelial cell complexes were isolated recently from normal murine thymus.
Porokeratosis palmaris, plantaris et disseminata vs. porokeratosis of Mibelli
Authors: R. Happle
Journal: British Journal of Dermatology (2011)

Journal Article Porokeratosis palmaris, plantaris et disseminata vs. porokeratosis of Mibelli Get access R. Happle R. Happle Department of Dermatology, Freiburg University Medical Center, Hauptstr. 7, 79104 Freiburg, Germany. E‐mail: rudolf.happle@uniklinik‐freiburg.de Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 166, Issue 3, 1 March 2012, Pages 681–682, https://doi.org/10.1111/j.1365-2133.2011.10626.x Published: 01 March 2012
The Global Burden of Potential Productivity Loss from Uncorrected Presbyopia
Authors: Kevin D. Frick, Susan M. Joy, David A. Wilson, Kovin S. Naidoo, Brien A. Holden
Journal: Ophthalmology (2015)

The onset of presbyopia in middle adulthood results in potential losses in productivity among otherwise healthy adults if uncorrected or undercorrected. The economic burden could be significant in lower-income countries, where up to 94% of cases may be uncorrected or undercorrected. This study estimates the global burden of potential productivity lost because of uncorrected functional presbyopia.Population data from the US Census Bureau were combined with the estimated presbyopia prevalence, age of onset, employment rate, gross domestic product (GDP) per capita in current US dollars, and near vision impairment disability weights from the Global Burden of Disease 2010 study to estimate the global loss of productivity from uncorrected and undercorrected presbyopia in each country in 2011. To allow comparison with earlier work, we also calculated the loss with the conservative assumption that the contribution to productivity extends only up to 50 years of age.The economic modeling did not require the use of subjects.We estimated the number of cases of uncorrected or undercorrected presbyopia in each country among the working-age population. The number of working-age cases was multiplied by the labor force participation rate, the employment rate, a disability weight, and the GDP per capita to estimate the potential loss of GDP due to presbyopia.The outcome being measured is the lost productivity in 2011 US dollars resulting from uncorrected or undercorrected presbyopia.There were an estimated 1.272 billion cases of presbyopia worldwide in 2011. A total of 244 million cases, uncorrected or undercorrected among people aged <50 years, were associated with a potential productivity loss of US $11.023 billion (0.016% of global GDP). If all those people aged <65 years are assumed to be productive, the potential productivity loss would be US $25.367 billion or 0.037% of global GDP. Correcting presbyopia to the level achieved in Europe would reduce the burden to US $1.390 billion (0.002% of global GDP).Even with conservative assumptions regarding the productive population, presbyopia is a significant burden on productivity, and correction would have a significant impact on productivity in lower-income countries.
Encrusted Pyelitis of Native Kidneys
Authors: ALEXANDRE HERTIG, CHRISTIAN DUVIC, YVES CHRETIEN, PAUL JUNGERS, JEAN-PIERRE GRU[Combining Diaeresis]NFELD, PHILIPPE RIEU
Journal: Journal of the American Society of Nephrology (2000)

Abstract. This study reports the first four cases of encrusted pyelitis involving native kidneys. The clinical features, management, and outcome of these patients were analyzed. Predisposing factors were underlying urologic disease and/or urologic manipulations, debilitating diseases, hospitalization, and prolonged antibiotic therapies. Presenting symptoms were renal failure in three patients with ureteroileal urinary diversion and manifestations of cystitis in one patient. Computed tomography scan of the urinary tract was critical for diagnosis. Presence of struvite was demonstrated by crystalluria and infrared spectrophotometry analysis of the encrusted material. Corynebacterium urealyticum urinary infection was identified in one case. Surgery (one patient) and palliative ureteral diversion (one patient), respectively, led to death and end-stage renal failure. Successful dissolution of encrusted pyelitis was obtained in two patients treated with intravenous vancomycin and local acidification of the renal collecting system. Clinical observation shows that encrusted pyelitis is a threatening disorder that destroys the native kidneys and may lead to end-stage renal failure. Successful treatment of the disease by chemolysis and antibiotics depends on correct and early diagnosis. Diagnosis required recognition of the predisposing factors, computed tomography imaging of the urinary tract, crystalluria, and identification of urea-splitting bacteria with prolonged culture on selective medium.
Measurement of a Monoclonal Antibody-Defined, Melanoma-Associated Antigen in Human Sera: Correlation of Circulating Antigen Levels With Tumor Burden&lt;xref ref-type="fn" rid="FN2"&gt;2&lt;/xref&gt;
Authors: A C Morgan, M M Crane, R D Rossen
Journal: JNCI Journal of the National Cancer Institute (1984)

Quantities of a 100,000-mol wt human melanoma-associated antigen (MAA), defined by both monoclonal and polyclonal xenoantibodies, were measured in sera of 32 patients with malignant melanoma and 15 carefully documented healthy volunteers by use of an amplified sandwich enzyme-linked immunoabsorbent assay. Detectable levels of MAA were found in all normal adult sera. Five of 10 patients with stage III and 9 of 16 patients with stage IV disease had antigen levels that exceeded. the 95th percentile of serum levels in the normal donors (P less than .001). Elevated levels of the 100K MAA were associated with evidence of residual tumor (P less than .008): Only 3 of 13 patients with no evidence of tumor had abnormal values, whereas 9 of 16 patients with evident tumor had increased serum levels. Levels of the 100K MAA were unrelated to the levels of soluble immune complexes as detected by the fluid-phase C1q binding test. Molecular evaluation of the 100K MAA in serum indicated that the molecule associated with albumin in a strong, noncovalent manner. When the complex was dissociated by treatment with sodium dodecyl sulfate, the 100K MAA in serum comigrated with the molecule from spent culture medium of human melanoma cells. Antigen levels in sera were measured under these dissociating conditions. These studies suggest that measurement of the 100K MAA may be useful in monitoring tumor burden in patients with malignant melanoma.
Allogeneic bone marrow transplant is not better than autologous transplant for patients with relapsed Hodgkin's disease. European Group for Blood and Bone Marrow Transplantation.
Authors: N Milpied, A K Fielding, R M Pearce, P Ernst, A H Goldstone
Journal: Journal of Clinical Oncology (1996)

PURPOSE To compare the results achieved with myeloablative therapy followed by either allogeneic bone marrow transplantation (alloBMT) or autologous bone marrow transplantation (ABMT) for patients with Hodgkin's disease (HD). PATIENTS AND METHODS Of more than 1,200 patients with HD reported to the European Bone Marrow Transplantation (EBMT) registry, 49 underwent alloBMT. Of these, 45 with sufficient data were matched to 45 patients who underwent ABMT. The matching criteria were sex, age at time of transplantation, stage of disease at diagnosis, bone marrow involvement at diagnosis and at transplantation, year of transplantation, disease status at time of transplantation, time from diagnosis to transplantation, and conditioning regimen with or without total-body irradiation (TBI). RESULTS The 4-year actuarial probabilities of survival, progression-free survival (PFS), relapse, and non-relapse mortality were 25%, 15%, 61%, and 48% and 37%, 24%, 61%, and 27% after alloBMT and ABMT, respectively. The toxic death rate at 4 years was significantly higher for alloBMT patients (P = .04). For patients with sensitive disease at the time of transplantation, the 4-year actuarial probability of survival was 30% after alloBMT and 64% after ABMT (P = .007). This difference is mainly due to a higher transplant-related mortality rate after alloBMT (65% v 12%, P = .005). Acute graft-versus-host disease (aGVHD) &gt; or = grade II was associated with a significantly lower risk of relapse, but also with a lower overall survival (OS) rate. CONCLUSION Based on this study, alloBMT from a human leukocyte antigen (HLA)-identical sibling donor does not appear to offer any advantage when compared with ABMT. A graft-versus-Hodgkin effect is associated with &gt; or = grade II aGVHD, but its positive effect on relapse is largely offset by its toxicity. In most circumstances, alloBMT cannot be recommended for patients with HD.
PCR tests in atypical infections of respiratory tract in children and the impact of these infections on the childhood asthma
Authors: Hanna Danielewicz, Wanda Balinska-Miskiewicz, Joanna Marciniak, Danuta Kalita, Anna Drabik-Chamerska, Andrzej Boznanski, Anna Debinska
Journal: European Respiratory Journal (2014)

Background. Mycoplasma pneumoniae ( Mp ) is one of the most important etiological factor of atypical infection of the respiratory tract. Mp is the pathogen responsible for 40% community-acquired pneumonia in school-age children. Diagnosis of Mp infection is based on the serological examination with the immunoenzymatic assay ELISA, but as well PCR test are possible.

Aim . The aim of the study was to assess the PCR assay value in the diagnostic process of Mp respiratory tract infection.

Material and methods. 87 children admitted to Clinic due to acute or recurrent respiratory tract infection or chronic cough were enrolled to the study and were performed with PCR test for Mp . For further analysis 73 children were qualified, within 20% were patients with asthma. 44 children were examined with ELISA serology test for Mp .

Results . In the group Mp infection was diagnosed due to serological examination in 9% of children, while the use of PCR allowed to diagnose Mp in 12 %. Children infected with Mp showed no elevated CRP, but in almost half (44%) ESR was increased together with relatively higher WBC values. Almost half of the children presented on physical examination involvement of the bronchi with auscultation findings like ronchi and/or wheezes, as well 44% were diagnosed with interstitial pneumonia. Spirometric tests analysis in children with acute Mp infection showed decreased FEV1/FVC, while those with former decreased FVC, although only few measurements were possible.

Conclusion. PCR test seems to be valuable for Mp diagnosis on the beginning of the infection. High proportion of the children with Mp infection showed symptoms of bronchi involvement.
Molecular and Clinical Remissions in Multiple Myeloma: Role of Autologous and Allogeneic Transplantation of Hematopoietic Cells
Authors: Paolo Corradini, Claudia Voena, Corrado Tarella, Monica Astolfi, Marco Ladetto, Antonio Palumbo, Maria Teresa Van Lint, Andrea Bacigalupo, Alessandra Santoro, Maurizio Musso, Ignazio Majolino, Mario Boccadoro, Alessandro Pileri
Journal: Journal of Clinical Oncology (1999)

PURPOSE: To describe molecular monitoring of minimal residual disease in patients with myeloma who have achieved complete remission (CR) after autologous or allogeneic transplantation of hematopoietic cells. MATERIALS AND METHODS: Clonal markers based upon the rearrangement of immunoglobulin heavy-chain genes were generated for each patient and used for polymerase chain reaction (PCR) detection of residual myeloma cells. Fifty-one patients entered the program and 36 achieved CR. After transplantation, molecular monitoring was performed on 29 patients (15 autologous and 14 allogeneic transplants) who had molecular markers. RESULTS: Our data show that molecular remissions are rarely achieved (7%) with high-dose chemotherapy followed by single or double autografting. In addition, virtually all peripheral blood progenitor cell and bone marrow samples contained residual myeloma cells, even when sample collection was scheduled after repeated courses of high-dose chemotherapy. All patients autografted with PCR-positive cells remain positive, and eight of 15 have relapsed. Two patients were autografted with PCR-negative cells: one is in clinical and molecular remission, and one relapsed 25 months after the transplant. In the allografting setting, a higher proportion of patients (50%) achieved molecular remission; there were two relapses, one in the PCR-positive group and one in the PCR-negative group. CONCLUSION: This is the first large study of molecular remissions in myeloma patients to use a PCR-based approach utilizing patient-specific tumor markers. The sizeable fraction of patients who achieved molecular remission after allografting with peripheral blood progenitor cells represents a promising finding in an incurable disease.
Cardiovascular diseases (CVD), arterial hypertension (AH) and diabetes mellitus (DM) in a cohort of 609 COPD patients: Associations with the new GOLD classification 2011
Authors: Andriana Papaioannou, Konstantinos Bartziokas, Stelios Loukides, Zoe Nouvaki, Stamatoula Tsikrika, Foteini Karakontaki, Emmanouil Kastanakis, Napoleon Karagiannidis, Aikaterini Haniotou, Spyridon Papiris, Konstantinos Kostikas
Journal: European Respiratory Journal (2013)

Background: CVD, AH and DM are common comorbidities in COPD. Their association with the new GOLD 2011 classification has not been evaluated.  Objective:To evaluate the prevalence of CVD, AH and DM in patients admitted to the hospital for COPD exacerbation (AECOPD).  Methods:609 patients admitted for AECOPD were followed-up monthly for one year.  Results:Patients’ classification according to GOLD 2011 and the prevalence of CVD, AH and DM are shown in Table 1. Comorbid diseases were more common in more severe COPD. Patients without comorbidities had fewer AECOPD in 1 year compared to patients with 1, 2 and 3 comorbidities (0.4±0.5, 1.9±2.5, 3.6±3.3 and 4.6±3.5 respectively, p  Conclusions:Cardiovascular comorbidities are common in patients admitted to the hospital with AECOPD and is associated with disease severity.The presence of comorbidities is associated with the number of AECOPD and hospitalizations for AECOPD in the following year.
Influence of Riboflavin on Disturbances in Tryptophan Metabolism and Hepatoma Production After a Single Dose of Aflatoxin B 1
Authors: F. J. Lemonnier, J. M. Scotto, C. Thuong Trieu
Journal: JNCI Journal of the National Cancer Institute (1975)

Female Wistar rats were given a single oral dose of aflatoxin B1, either alone or with a large amount of riboflavin. Biochemical and histologic studies were performed for 30 months. Nine animals of 19 in the aflatoxin-treated group and only 5 of 18 in the riboflavin-aflatoxin-treated group developed hepatomas. The number of rats was insufficient for tests of statistical significance to be fruitful. Urinary excretion of tryptophan metabolites was studied in aflatoxin- and riboflavin-treated rats after an oral administration of 10 mg tryptophan/100 g rat. Riboflavin did not affect the percentage of aflatoxin-treated animals with abnormal urinary excretion patterns, but did increase the magnitude of the disturbances in elimination of kynurenic and xanthurenic acids. The hepatic tryptophan-oxygenase activity was increased only in the two groups given riboflavin, and the levels of nucleic acids were the same in all groups.
Difficult/therapy‐resistant asthmaThe need for an integrated approach to define clinical phenotypes, evaluate risk factors, understand pathophysiology and find novel therapies
Authors: K F Chung, P Godard, E Adelroth, J Ayres, N Barnes, P Barnes, E Bel, P Burney, P Chanez, G Connett, C Corrigan, J de Blic, L Fabbri, S T Holgate, P Ind, G Joos, H Kerstjens, P Leuenberger, C G Lofdahl, S McKenzie, H Magnussen, D Postma, M Saetta, S Salmeron, P Sterk
Journal: European Respiratory Journal (1999)

A Task Force supported by the European Respiratory Society was set up in 1997 in order to address the major issues relevant to difficult/therapy-resistant asthma.Although the group of patients involved is small in comparison to the high numbers of patients with asthma, these patients consume a significant proportion of medical resources in terms of both time and money [1].The major issues facing the Task Force were how to define "difficult asthma", how the patient with difficult asthma should be evaluated, the pathophysiological mechanisms underlying difficult asthma and the treatments available.The Task Force also concerned itself with defining the areas of research necessary to bring about a greater understanding of the causes of difficult asthma and novel treatments.The document resulting from this Task Force represents a consensus of different opinions, which will form the basis for further research. Formulating the definitionA large number of terms are used by clinicians when referring to asthmatic patients who have "difficult to treat" disease: difficult acute, difficult chronic, chronic severe, acute severe, therapy-resistant, difficult to control, corticosteroid-resistant or corticosteroid-dependent, symptomatic, life-threatening, and fatal.An encompassing inclusive rather than exclusive definition was sought and the use of the term "difficult/therapy-resistant asthma" was adopted to include all such cases of asthma of all age groups.Since wheezing disorders in preschool children are poorly characterized, this report specifically excludes children below the age of 5 yrs.Response to therapy is included in this concept and will have research implications.It was accepted that the definition needed to be inclusive, although losing some precision, but it was also recognized that its