NOTES ON 250 CASES OF SUBACUTE BACTERIAL (STREPTOCOCCAL) ENDOCARDITIS STUDIED AND TREATED BETWEEN 1927 AND 1939
Authors: Saul R. Kelson, Paul D. White
Journal: Annals of Internal Medicine (1945)

Article1 January 1945NOTES ON 250 CASES OF SUBACUTE BACTERIAL (STREPTOCOCCAL) ENDOCARDITIS STUDIED AND TREATED BETWEEN 1927 AND 1939SAUL R. KELSON, M.D., PAUL D. WHITE, M.D., F.A.C.P.SAUL R. KELSON, M.D., PAUL D. WHITE, M.D., F.A.C.P.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-22-1-40 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptIn order to understand more fully the clinical picture of subacute bacterial (streptococcal) endocarditis,† to determine the effects of treatment prior to the intensive use of the newer chemotherapeutic drugs, and to establish a baseline of prognosis particularly as a means of evaluating therapy, we have analyzed the records of 250 patients with this disease in certain Boston hospitals‡ and in private practice§ from January 1927 to March 1939.Although excellent reviews of this disease have been published in the past and collections of cases assembled, as in the writings of Libman and Friedberg,1Blumer,2Morrison,3and Christian,4it was...Bibliography1. LIBMANFRIEDBERG ECK: Subacute bacterial endocarditis, 1941, Oxford University Press, New York. 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FAULKNER JM: The effect of administration of vitamin C on the reticulocytes in certain infectious diseases; preliminary report, New England Jr. Med., 1935, ccxiii, 19. CrossrefGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Boston, Massachusetts*Received for publication October 1, 1944.†The separation of bacterial endocarditis into "acute" and "subacute" forms, according to the causative organisms, the presence of a primary infective focus and of previous heart impairment, the duration of the disease, the height of the fever, etc. is generally useful but by no means exact. The Streptococcus viridans may cause a fulminating infection, and a usually virulent organism like the beta hemolytic streptococcus a lingering one. "Subacute" infections may rarely attack hearts without evidence of antecedent disease, and the bacteria of the "acute" variety may implant on impaired valves. Embolism sometimes kills abruptly after a few weeks or even days of a typically "subacute" course; not infrequently, fever spikes to 105° F. in a case of "endocarditis lenta." Designating the organism, with or without the addition of the term "acute" or "subacute," is preferable to using one of these terms alone.‡The Massachusetts General, Beth Israel, Peter Bent Brigham, and Massachusetts Memorial Hospitals, to whose staffs we express our indebtedness and gratitude for permission to include their cases.§Of Dr. Paul D. White and Dr. T. Duckett Jones. To Dr. Jones we herewith express our appreciation for permission to refer to his cases. 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WALLACH, M.D., MACELLIS GLASS, B.A., LESLIE LUKASH, M.D., ALFRED A. ANGRIST, M.D.Diagnosis and Prevention of Bacterial EndocarditisThe Role of the Pulpless Tooth in Systemic Disease: A SummaryThe Role of Periodontal Foci of Infection in Systemic Disease: An Evaluation of the LiteratureRole of Dental Focal Infection in Etiology of DermatosisThe Lewis A. Conner Lecture of the American Heart AssociationLong-Term Follow-up Study of Penicillin-Treated Subacute Bacterial EndocarditisBacterial Endocarditis in the ElderlyBacterial Endocarditis Following Surgery, Particularly Surgery of the Urinary TractThe treatment of subacute bacterial endocarditis with antibiotics 1 January 1945Volume 22, Issue 1Page: 40-60KeywordsBacterial diseasesCardiovascular therapyEndocarditisFeversGratitudeHeart diseasesInfectious diseasesMyocardial infarctionStreptococcal infectionsStreptococcus ePublished: 1 December 2008 Issue Published: 1 January 1945 PDF downloadLoading ...