tbuckley/cabot-search huggingface dataset:
Rapid inpatient and outpatient desensitization for carboplatin or paclitaxel hypersensitivity: A protocol effective in patients with gynecologic malignancies
Authors: C.-W. Lee, U. A. Matulonis, S. M. Campos, A. H. Gross, C. M. Hayes, K. T. Keenan, M. C. Castells
Journal: Journal of Clinical Oncology (2005)

5090 Background: The purpose of the study was to investigate the safety and efficacy of a rapid desensitization protocol used in the inpatient and outpatient settings for patients with hypersensitivity reactions (HR) to carboplatin or paclitaxel. Methods: The 3-solution, 12-step protocol combined gradual increases in the rate of infusion and concentration of the chemotherapy, infusing the target dose over 5.8 hours for inpatient and 3.8 hours for outpatient administration. Patients were premedicated with antihistamines without additional corticosteroids. Results: Between February 2000 and December 2004, 45 patients with history of ovarian (n=39), fallopian (n=3), endometrial (n=2), and peritoneal (n=1) cancer who had moderate to severe HR to either carboplatin or paclitaxel were evaluated. The 26 patients who reacted to carboplatin received a median of 8 courses before developing their initial HR while 16 of 19 patients with HR to paclitaxel reacted on their first exposure to the agent. 17 of 22 patients with HR to carboplatin had positive skin tests. All 45 patients successfully completed 195 planned courses of desensitization (88 courses of carboplatin and 107 of paclitaxel). After undergoing successful inpatient desensitization, 6 patients thus far have received 22 desensitizations in the outpatient setting without adverse reactions. Of 26 patients receiving carboplatin desensitization for recurrent cancer, 10 had a radiographic response (partial or complete response) and/or >50% drop of initial CA125 value, 11 had stable disease radiographically and/or CA125 response (<50% drop), 1 is still unevaluable for response, and 4 had progressive disease after 2 cycles of carboplatin. Conclusions: The rapid desensitization protocol has proven to be safe and effective in the inpatient and outpatient settings for patients with HR to either carboplatin or paclitaxel. This protocol has allowed appropriate patients to continue chemotherapy in the setting of moderate to severe HR, and the study warrants the incorporation of the protocol into standard clinical practice. No significant financial relationships to disclose.
Work‐related stress, inability to relax after work and risk of adult asthma: a population‐based cohort study
Authors: A. Loerbroks, M. C. Gadinger, J. A. Bosch, T. Stürmer, M. Amelang
Journal: Allergy (2010)

There is an extensive literature linking stressful work conditions to adverse health outcomes. Notwithstanding, the relationship with asthma has not been examined, although various other measures of psychological stress have been associated with asthma. Therefore, we aimed to investigate the relation between work stress and asthma prevalence and incidence.We used data from a population-based cohort study (n = 5114 at baseline in 1992-1995 and n = 4010 at follow-up in 2002/2003). Asthma was measured by self-reports. Two scales that assessed psychologically adverse work conditions were extracted from a list of work-condition items by factor analysis (these scales were termed 'work stress' and 'inability to relax after work'). For each scale, the derived score was employed both as continuous z-score and as categorized variable in analyses. Associations with asthma were estimated by prevalence ratios (PRs) and risk ratios (RRs) using Poisson regression with a log-link function adjusting for demographics, health-related lifestyles, body mass index and family history of asthma. Analyses were restricted to those in employment (n = 3341).Work stress and inability to relax z-scores were positively associated with asthma prevalence (PR = 1.15, 95%CI = 0.97, 1.36 and PR = 1.43, 95%CI = 1.12, 1.83, respectively). Prospective analyses using z-scores showed that for each 1 standard deviation increase in work stress and inability to relax, the risk of asthma increased by approximately 40% (RR for work stress = 1.46, 95%CI = 1.06, 2.00; RR for inability to relax = 1.39, 95%CI = 1.01, 1.91). Similar patterns of associations were observed in analyses of categorized exposures.This is the first study to show a cross-sectional and longitudinal association of work stress with asthma.
Young female alcoholics with and without eating disorders: a comparative study in Japan
Authors: K Suzuki, S Higuchi, K Yamada, Y Mizutani, H Kono
Journal: American Journal of Psychiatry (1993)

The authors sought to delineate the characteristics of female alcoholics with eating disorders.The study subjects were 29 female Japanese outpatients and inpatients, 30 years of age or younger, with DSM-III-R diagnoses of either alcohol dependence or alcohol abuse and eating disorders. Twenty-one female alcoholics within the same age range who did not have eating disorders served as the comparison group. The social and familial backgrounds, clinical course, and clinical symptoms of the two groups were compared with the use of a structured interview form developed for the study.Ninety-three percent of the subjects with eating disorders had bulimia nervosa; 52% had anorexia nervosa. In all cases, both disorders continued after the onset of problem drinking. The age distributions of the two groups of alcoholic subjects clearly differed: no one in the comparison group was under the age of 24, and the number of comparison subjects increased with age after age 24, whereas the subjects with eating disorders ranged in age from 19 to 30 years, with the greatest number at age 26. More of the alcoholic subjects with eating disorders had never been married, they had had an earlier onset of alcoholism, and they had lower body weights than those without eating disorders. Also, more of them had depression and borderline personality disorder.The findings suggest that young female alcoholics with eating disorders constitute a clinical subgroup of alcoholics with distinct sociodemographic characteristics and a clinical course and symptoms that differ from those of both younger and older female alcoholics without eating disorders.
The short-term prognostic value of forced expiratory volume in 1 second divided by height cubed (FEV1.Ht-3) in a prospective cohort of people 80 years and older
Authors: Eralda Turkeshi, Bert Vaes, Elena Andreeva, Catharina Mathei, Wim Adriaensen, Gijs Van Pottelbergh, Jan Degryse
Journal: European Respiratory Journal (2014)

Introduction:  FEV1.Ht -3  is one of the new ways of expressing FEV1 that have been found to be superior to the common expression as percentage of predicted normal values (FEV1%) in establishing an association between FEV1 and all-cause mortality. No data are available yet on the prognostic value of FEV1.Ht -3  in the very old adults (80 years and older) and its correlation with other adverse outcomes.   Aims and objectives:  This study aims to investigate the hypothesis that FEV1.Ht -3  is a good predictor of all-cause mortality, hospitalizations, physical and mental decline in the very old adults.   Methods:  In a prospective cohort study of 567 people of 80 years and older in Belgium, the lowest quartile of FEV1.Ht -3  was plotted in Kaplan-Meier curves for 3-year mortality and hospitalization rates. Multivariable analysis adjusted for age, sex, smoking status, inflammatory markers and co-morbidities examined the association of FEV1.Ht -3  with mortality, hospitalization, physical and mental decline.   Results:  Individuals in the lowest quartile of FEV1.Ht-3 had a statistically significant increased risk for mortality (HR 2.04, 95% CI 1.36-3.06; p   Conclusions:  In a cohort of very old adults, the lowest quartile of FEV1.Ht -3  showed a good prognostic value for mortality, hospitalization rates and mental decline, but not for physical decline. Further research is needed on the use of FEV1.Ht -3  in this age group and comparison with other expressions of FEV1.
Long-Term Functional Persistence, B Cell Aplasia and Anti-Leukemia Efficacy In Refractory B Cell Malignancies Following T Cell Immunotherapy Using CAR-Redirected T Cells Targeting CD19
Authors: Michael Kalos, Farzana Nazimuddin, Jeffrey M. Finklestein, Minnal Gupta, Irina Kulikovskaya, David E. Ambrose, Saar Gill, Simon F. Lacey, Zhaohui Zheng, J. Joseph. Melenhorst, Bruce L. Levine, Noelle V. Frey, Stephan A. Grupp, David L. Porter, Carl H. June
Journal: Blood (2013)
Impaired lung function in children born preterm is related to severity of neonatal lung disease
Authors: Karla M. Logie, James T.D. Gibbons, Shannon J. Simpson, Andrew C. Wilson, J. Jane Pillow, Graham L. Hall
Journal: European Respiratory Journal (2011)

Advances in neonatal care have led to a shift in the pathophysiology of bronchopulmonary dysplasia (BPD). The impact of contemporaneous preterm birth and BPD on long term respiratory health remains unclear. This study aims to relate mid-childhood respiratory function with neonatal variables in children born ≤32 w gestational age (GA).   Methods:  Children aged 9 to 11 y (≥ 37 w GA controls, n=37; 84 born ≤32 w gestation including 53 with BPD) performed 4 lung function tests (forced oscillation, static lung volumes, spirometry and gas transfer (DLCO)). Associations between lung function (expressed as Z scores) and neonatal variables (GA, birth weight Z-score and durations of mechanical ventilation (MV) and O 2 ) were explored using multiple linear regression.   Results:  Children with BPD had increased respiratory resistance (R rs ) and reactance (X rs ), reduced FEV 1  and FEF 25-75  compared to children born preterm without BPD and controls (one-way ANOVA; post-hoc comparisons p 2  was associated with increased R rs  (p rs  (p=0.001) and together with birth weight Z-score (p=0.02), was predictive of reduced FEV 1  (p=0.005).   Conclusions:  Children born ≤32w GA with BPD have worse lung function compared to preterm children without BPD. Impaired lung function in mid-childhood is associated with severity of neonatal lung disease as reflected by duration of MV and supplemental O 2 , further reinforcing the long–term impacts of preterm birth on lung health.
John C Willke
Authors: N. Stafford
Journal: BMJ (2015)

Carbonic anhydrase (CA) activity in the brain extracellular space is attributable mainly to isoforms CA4 and CA14. In brain, these enzymes have been studied mostly in the context of buffering activity-dependent extracellular pH transients. Yet evidence from others has suggested that CA4 acts in a complex with anion exchangers (AEs) to facilitate Cl<sup>−</sup>–HCO<sub>3</sub><sup>−</sup> exchange in cotransfected cells. To investigate whether CA4 or CA14 plays such a role in hippocampal neurons, we studied NH<sub>4</sub><sup>+</sup>-induced alkalinization of the cytosol, which is mitigated by Cl<sup>−</sup> entry and HCO<sub>3</sub><sup>−</sup> exit. The NH<sub>4</sub><sup>+</sup>-induced alkalinization was enhanced when the extracellular CAs were inhibited by the poorly permeant CA blocker, benzolamide, or by inhibitory antibodies specific for either CA4 or CA14. The NH<sub>4</sub><sup>+</sup>-induced alkalinization was also increased with inhibition of anion exchange by 4,4*-diisothiocyanostilbene-2,2*-disulfonic acid, or by eliminating Cl<sup>−</sup> from the medium. No effect of benzolamide was seen under these conditions, in which no Cl<sup>−</sup>–HCO<sub>3</sub><sup>−</sup> exchange was possible. Quantitative PCR on RNA from the neuronal cultures indicated that AE3 was the predominant AE isoform. Single-cell PCR also showed that Slc4a3 (AE3) transcripts were abundant in isolated neurons. In hippocampal neurons dissociated from AE3-null mice, the NH<sub>4</sub><sup>+</sup>-induced alkalinization was much larger than that seen in neurons from wild-type mice, suggesting little or no Cl<sup>−</sup>–HCO<sub>3</sub><sup>−</sup> exchange in the absence of AE3. Benzolamide had no effect on the NH<sub>4</sub><sup>+</sup>-induced alkalinization in the AE3 knock-out neurons. Our results indicate that CA4 and CA14 both play important roles in the regulation of intracellular pH in hippocampal neurons, by facilitating AE3-mediated Cl<sup>−</sup>–HCO<sub>3</sub><sup>−</sup> exchange.
Rhabdomyosarcoma: the Stanford experience using a TNM staging system.
Authors: T J Pedrick, S S Donaldson, R S Cox
Journal: Journal of Clinical Oncology (1986)

Seventy-four patients with rhabdomyosarcoma were initially staged according to the Intergroup Rhabdomyosarcoma Study (IRS) grouping classification and then retrospectively using a TNM staging system based on the initial clinical extent of disease. The TNM system includes T1, tumor confined to site or organ of origin; T2, regional extension beyond the site of origin; N0, normal lymph nodes; N1, lymph nodes containing tumor; M0, no evidence of metastases; and M1, distant metastases. All patients received combination chemotherapy, and more than 90% received radiation therapy as part of their initial treatment program with curative intent. Fifty-three of 74 patients (72%) were group III according to the IRS system, indicating unresectable or gross residual tumor. A more uniform distribution was achieved using the TNM system. Freedom from relapse (FFR) was 43% and the actuarial survival rate was 47% for the entire study group at 10 years. All but one relapse occurred within 3 years of initial diagnosis, and only three of 38 relapsed patients were salvaged. All TNM stage I patients are surviving disease free. Among patients having stages II, III, and IV disease by the TNM system, FFR was 53%, 26%, and 11%, and the survival rates were 47%, 36%, and 33%, respectively. Thirty-two of 74 patients (43%) had evidence of lymph node involvement at presentation, and 28 (88%) of these had primary lesions that extended beyond the site of origin (T2 primary). Histologic subtype and primary site had little impact on outcome in a multivariate analysis, and T stage was identified as the single most significant covariate correlated with survival; a model composed of both T stage and M stage was the best one for predicting relapse. The presented data support a study using a prospectively assigned TNM staging system based on the initial clinical extent of disease for use in future therapeutic trials.
Serum heat shock protein levels in patients with chronic obstructive pulmonary disease
Authors: Ramazan Ünver, Figen Deveci, Gamze Kirkil, Dilara Kaman
Journal: European Respiratory Journal (2014)

The aim of this study was determining the level of heat shock proteins (HSPs) secreted by various stress conditions and the relationship of HSPs with various parameters (inflammatory, oxidative, functional status, quality of life) in COPD.

The levels of stress protein (HSP27, HSP70, HSP60, HSP90, CyPA), interleukin-6, C-reactive protein and malondialdehyde were measured in 16 healthy non-smoker (Group I), 14 smokers without COPD (Group II) and 50 patients with stable COPD (Group III). Body mass index, pulmonary function tests and arterial blood gases parameters were measured. Health Related Quality of Life was assessed using the St. George's Respiratory Questionnaire and exercise capacity was assessed with 6 minute walking test (6mwt).

Only HSP27 levels was significantly higher in group III when compared with both group I and group II (for both, p<0.001). There was a weak to moderate negative correlation between serum levels of HSP27 and PFT parameters (r= -0.428 for FEV1, r= -0.389 for FVC and r= -0.383 for FEV1/FVC, p<0.01 for all) and between HSP27 levels and PaO2 (r= -367, p<0.01). Only weak to moderate positive correlation were found between serum levels of HSP60 and IL-6 levels (r= 0.327, p<0.05). Serum levels of HSP27 showed a weak to moderate positive correlation with symptom, activity and total scores (r= 0.351 for symptom, r= 0.294 for activity, r= 0.316 for total score, p<0.05 for all).

Increased HSP27 levels in COPD patients suggest that HSP27 may have a potential role in the pathogenesis of COPD associated with hypoxia. In addition, HSP27 may be an indicator associated with patient's functional status, quality of life and duration of disease.
Abstract 15852: Platelet Inhibition With PA32540 (a Tablet of Enteric-Coated Aspirin and Immediate-Release Omeprazole ) + Clopidogrel Dosed Separately is Greater Than Enteric-Coated Aspirin + Enteric-Coated Omeprazole + Clopidogrel Dosed Synchronously: Results of a Randomized, Open-Label, Cross-Over Study
Authors: Paul A Gurbel, Kevin P Bliden, Tania Gesheff, Ying Zhang, Martin Gesheff, Udaya Tantry
Journal: Circulation (2011)

Background: PA32540 is a novel combination product of enteric-coated (EC) aspirin (ASA) and immediate-release (IR) omeprazole intended for secondary prevention of cardiovascular events in patients ...
Abstract 2363: Longer Duration of Continuous Flow Ventricular Assist Device Support Predicts Greater Hemodynamic Compromise with Return to Pulsatility
Authors: Mark J Russo, Timothy P Martens, Mario C Deng, Ray Wang, Michael Argenziano, Mehmet C Oz, Yoshifumi Naka, Allan S Stewart
Journal: Circulation (2006)

PURPOSE: To determine if duration of continuous flow ventricular assist device (CVAD) support is associated with greater pressor requirements after return to pulsatile flow. METHODS: The study popu...
Long-Term Chimerism and B-Cell Function After Bone Marrow Transplantation in Patients With Severe Combined Immunodeficiency With B Cells: A Single-Center Study of 22 Patients
Authors: Elie Haddad, Françoise Le Deist, Pierre Aucouturier, Marina Cavazzana-Calvo, Stephane Blanche, Geneviève De Saint Basile, Alain Fischer
Journal: Blood (1999)
A New Inhalation Technique for Freon Aerosols
Authors: N. E. Eriksson, K. Haglind, K. G. Hidinger
Journal: Allergy (1980)

In a double‐blind, cross‐over, 2‐day study 32 adult asthmatic patients compared the bronchodilating effect of 0.5 mg terbutaline sulphate aerosol, administered via a 10 cm tube extension attached to the actuator of a pressurized aerosol, with that of 0.2 mg salbutamol sulphate, administered by a conventional pressurized aerosol. New instructions for the inhalation technique were given for the terbutaline aerosol, dividing the actuation of the aerosol and the slow inhalation into two steps. The salbutamol aerosol was to be taken according to the instructions enclosed, i.e. coordinating the actuation of the aerosol and the inhalation. The improvement in peak expiratory flow rate (PEFR)values was similar for the two treatments. Subjective assessments by the patients showed no differences between the two regimens. As the effect seems to be equal, an aerosol actuator furnished with a tube extension, with no strict demands of synchronizing the actuation of the aerosol and the inhalation, could be a suitable alternative treatment in patients who find self‐administration with conventional asthma aerosols difficult.
In Defense of Nudge–Autonomy Compatibility
Authors: J. S. Blumenthal-Barby, Aanand D. Naik
Journal: The American Journal of Bioethics (2015)

In their article “Doctors, Patients, and Nudging in the Clinical Context—Four Views on Nudging and Informed Consent,” Thomas Ploug and Soren Holm argue that nudging is inconsistent with autonomy pr...
Use of telemedicine in patients with chronic respiratory failure
Authors: Shokoofe Eslami, Rita Le Donne, Maria Teresa Pugliesi, Elia Pochini, Giacinto Di Gianfilippo, Paola Lunari, Luigina Quondamstefano, Simona Silvestri
Journal: European Respiratory Journal (2013)

Telemedicine is an innovative approach to help the medical team that integrates hospital and territory in a chronic patient care.  The aim of this study is to evaluate it’s effectiveness in a sample of patients with Chronic Respiratory Failure (CRF).  From June 2009 through February 2013 a specialized nurse followed the main vital signs of 64 patients(28 Male, 36 Female; mean age 71.6 ± 9.3 years) in Long Term O 2  Therapy(LTOT) and/or mechanical ventilation (VM). In the presence of variation of vital signs and conditions of patients, a general practitioner and the specialist pulmonologist were alerted by these changes. The average number of days of hospitalization and daily average consumption of O 2  in the year prior to enrollment were compared to those found in the next two years of study. For evaluating statistical significance, the Student9s t test was used.  During this observation period, 8 patients (10.9%) have abandoned the project and 22 patients (34.4%) died of their complication (higher mortality rate seen among patients with chronic obstructive pulmonary disease (64.7%)). In 26 patients (Male 6, Female 20; average age 66.5± 13.4), with at least one year follow up has detected a statistically significant reduction in the average of daily consumption of O 2  (2601,8± 1683,7 versus 1930,4± 1643,3 l/day -p=0,018) and number of days of hospitalization (16,9± 25,9 versus 4,3± 8,3 days -p=0,027), and the result preserved in 21 patients with two years follow up (17,3± 28,2 versus 4± 8 -p=0,034).  The data demonstrates the usefulness and effectiveness of a Tele-nursing and telemonitoringin patients with severe respiratory disease which are in LTOT and/ or VM.
Abstract 441: Functional characterization of recurrent CD74-NRG1 fusions in lung adenocarcinoma
Authors: Dennis Plenker, Lynnette Fernandez-Cuesta, Hirotaka Osada, Ruping Sun, Marc Bos, Juliane Daßler, Gavin Wright, Elisabeth Brambilla, Reinhard Büttner, Sascha Ansen, Stefan Haas, Yasushi Yatabe, Roman K. Thomas
Journal: Cancer Research (2014)

Abstract In nearly 50% of all lung adenocarcinomas the oncogenic driver is still unknown. We performed transcriptome sequencing on 25 pan-negative lung adenocarcinomas of never smokers leading to the identification of the novel CD74-NRG1 gene fusion. In an additional cohort of 102 adenocarcinomas we could identify and validate four additional cases bearing the CD74-NRG1 fusion gene - all of the invasive mucinous subtype. We then transduced NIH-3T3 cells with the fusion and found it localized on the cell surface in FACS experiments. As we found the identical breakpoint in CD74 in our fusion as in CD74-ROS1, we hypothesized that the functional active part needs to be NRG1. (Soda et al. 2012) The NRG1 isoform III-β3 that we found is generally not expressed in lung tissue - therefore the CD74 part leads to the expresseion of NRG1 III-β3 in the lung. As Neuregulins are known interaction partners of HER receptor family members we transduced the human adenocarcinoma cell lines H322 and H1568, that are HER receptor and KRAS wildtype, with the fusion and found phosphorylation of HER2 and HER3 in the transduced cells under starvation conditions compared to empty vector controls. (Hobbs et al. 2002) This holds true as well in the patient situation in which phospho-HER3 was only found in tumors expressing the fusion (p&amp;lt;0.0001). We could further show that the CD74-NRG1 fusion is associated with activation of the phosphoinsitide-3-kinase pathway activation and the mitogen-activated protein (MAP) kinase pathway . As functional consequence we could observe in several human adenocarcinoma cell lines increased colony forming ability in soft-agar assays showing the CD74-NRG1 fusion being a new oncogenic driver in lung adenocarcinoma. This finding may lead to new treatment options for patients harboring this fusion gene who do not benefit from any effective treatment option up to now. Citation Format: Dennis Plenker, Lynnette Fernandez-Cuesta, Hirotaka Osada, Ruping Sun, Marc Bos, Juliane Daßler, Gavin Wright, Elisabeth Brambilla, Reinhard Büttner, Sascha Ansen, Stefan Haas, Yasushi Yatabe, Roman K. Thomas. Functional characterization of recurrent CD74-NRG1 fusions in lung adenocarcinoma. [abstract]. In: Proceedings of the 105th Annual Meeting of the American Association for Cancer Research; 2014 Apr 5-9; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2014;74(19 Suppl):Abstract nr 441. doi:10.1158/1538-7445.AM2014-441