tbuckley/cabot-search huggingface dataset:
Vascular bed-targeted in vivo gene delivery using tropism-modified adeno-associated viruses
Authors: Lorraine M. Work, Hildegard Büning, Ela Hunt, Stuart A. Nicklin, Laura Denby, Nicola Britton, Kristen Leike, Margarete Odenthal, Uta Drebber, Michael Hallek, Andrew H. Baker
Journal: Molecular Therapy (2006)

Virus-mediated gene delivery is restricted by the infectivity profile of the chosen vector. Targeting the vascular endothelium via systemic delivery has been attempted using peptides isolated in vitro (using either phage or vector display) and implicit reliance on target receptor expression in vivo. This has limited application since endothelial cells in vitro and in vivo differ vastly in receptor profiles and because of the existence of complex endothelial "zip codes" in vivo. We therefore tested whether in vivo phage display combined with adeno-associated virus (AAV) capsid modifications would allow in vivo homing to the endothelium residing in defined organs. Extensive in vivo biopanning in rats identified four consensus peptides homing to the lung or brain. Each was incorporated into the VP3 region of the AAV-2 capsid to display the peptide at the virion surface. Peptides that conferred heparan independence were shown to retarget virus to the expected vascular bed in vivo in a preferential manner, determined 28 days post-systemic injection by both virion DNA and transgene expression profiling. Our findings significantly impact the design of viral vectors for targeting individual vascular beds in vivo.
Rho inhibitor prevents ischemia–reperfusion injury in rat steatotic liver
Authors: Shintaro Kuroda, Hirotaka Tashiro, Yuka Igarashi, Yoshisato Tanimoto, Junko Nambu, Akihiko Oshita, Tsuyoshi Kobayashi, Hironobu Amano, Yuka Tanaka, Hideki Ohdan
Journal: Journal of Hepatology (2011)
Blood Cultures Drawn from Indwelling Central Venous Catheters
Authors: James R. Johnson
Journal: Annals of Internal Medicine (2000)

Letters6 June 2000Blood Cultures Drawn from Indwelling Central Venous CathetersJames R. Johnson, MDJames R. Johnson, MDVeterans Affairs Medical Center; Minneapolis, MN 55417Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-132-11-200006060-00016 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:DesJardin and colleagues' report on the clinical utility of blood cultures drawn through indwelling catheters contains several potentially misleading statements and an important omission (1). The abstract emphasizes the low positive predictive value of catheter-drawn blood cultures, implies that the positive predictive value is lower for catheter-drawn than for peripherally drawn cultures, and suggests a need for clinical interpretation or confirmation of results specifically for catheter-drawn cultures.However, the data do not show a significant difference in positive predictive value between catheter-drawn and peripherally drawn cultures. Thus, they indicate that positive results from peripherally drawn blood cultures ...Reference1. DesJardin JA, Falagas ME, Ruthazar R, Griffith J, Wawrose D, Schenken D, et al . Clinical utility of blood cultures drawn from indwelling central venous catheters in hospitalized patients with cancer. Ann Intern Med. 1999;131:641-7. LinkGoogle Scholar Author, Article, and Disclosure InformationAuthors: James R. Johnson, MDAffiliations: Veterans Affairs Medical Center; Minneapolis, MN 55417 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoClinical Utility of Blood Cultures Drawn from Indwelling Central Venous Catheters in Hospitalized Patients with Cancer Jeffrey A. DesJardin , Matthew E. Falagas , Robin Ruthazer , John Griffith , Dorothy Wawrose , David Schenkein , Kenneth Miller , and David R. Snydman Blood Cultures Drawn from Indwelling Central Venous Catheters David R. Snydman and Robin Ruthazer Metrics Cited byDeveloping a Protocol for Obtaining Blood Cultures From Central Venous Catheters and Peripheral Sites 6 June 2000Volume 132, Issue 11Page: 922KeywordsBloodCathetersInfectious diseasesPositive predictive value ePublished: 15 August 2000 Issue Published: 6 June 2000 Copyright & PermissionsCopyright © 2000 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Leukemic fusion genes MLL/AF4 and AML1/MTG8 support leukemic self-renewal by controlling expression of the telomerase subunit TERT
Authors: A Gessner, M Thomas, P Garrido Castro, L Büchler, A Scholz, T H Brümmendorf, N Martinez Soria, J Vormoor, J Greil, O Heidenreich
Journal: Leukemia (2010)
Did the subjects and the controls have the same disease?
Authors: Romain J Forestier, Fatma Begum Erol Forestier
Journal: Annals of the Rheumatic Diseases (2015)

The article by Roberts et al 1 is important because it points to potential occurrence of side effects due to paracetamol, some of which are life-threatening. However, we have some doubts about the conclusions because it is not certain that …
Medical Ozone (O3) Oil or Gas Applications Heal Osteonecrosis of the Jaw (ONJ) in Patients Treated with Bisphosphonates (BPs). Preliminary Results of a Single Arm Study.
Authors: C. Ripamonti, M. Maniezzo, R. Ghiringhelli, E. Cislaghi, L. Mariani
Journal: Cancer Research (2009)

Abstract Treatment of bone metastasis with BP is aimed at preventing skeletal related events (SREs) and rarely leads to ONJ (&amp;lt;1%) (Hoff, JBMR. 2008). Preventive dental care is a simple and effective way to reduce the risk reduction of ONJ in 75% of the cases (Ripamonti, Ann Oncol. 2009). To date, there are still no standardized therapy for the treatment of ONJ. We report the effect of localized of O3 oil or gas application in cancer patients (12 breast cancer, 4 prostate cancer, 2 lung cancer, 1 NHL, 3 multiple myeloma) with ONJ observed in our institution. Patients had previously received nitrogene-BPs treatment in the absence of odontoiatric preventive measures. All the patients were in had stable disease without progression; 10 of them had ONJ lesions ≤ to 2.5 cm.O3 oil suspension applications on ONJ lesions ≤ 2.5 cm was carried out with localized applications directly on the lesions; patients with larger lesions (≥ 2.5 cm) were treated with the ozone gas locally applied. All the patients received treatment of O3 oil every third day and all of them were treated with antibiotic therapy (azithromycin, 500 mg/day) 10 days prior the initiation of the treatment with O3 oil. The statistical analysis is based on a Simon two-stage design, the second stage is on-going. In this preliminary analysis we focus on 10 patients treated with O3 oil with a medium follow up of 8 months, and 12 patients on medical gas ozone.73% of the patients (n=16) showed complete response in terms of radiological lesion disappearance with complete reconstruction of oral tissue. Among them, fourteen patients developed spontaneous sequestrum with expulsion of the necrotic bone whereas in 2 patients with large extension of bone involvement surgical intervention was necessary.Seventy percent of the patients treated with O3 oil experienced a complete response after 4 applications whereas patients treated with gas needed 4 to 16 applications (depending on the severity of the lesion). No patients presented adverse events related to the use of ozone treatments. Six patients are still on treatment and are improving as well.According to these results few application of O3 oil suspension in patients with smaller lesions and gas medical ozone for wider lesions following antibiotic therapy can rapidly lead to complete healing of ONJ. Further cases and complete follow-up data are required. These data indicate that ONJ is a manageable condition which can be not only prevented by means previously dental examination but also healed with medical ozone applications. Citation Information: Cancer Res 2009;69(24 Suppl):Abstract nr 5046.
GASTRIC HAEMORRHAGE AND OTHER COMPLICATIONS IN A CASE OF CHILDBIRTH
Authors: W. D. Sturrock
Journal: BMJ (1913)

RNAL I [E .I 93 experience led to abscess formation.Disease of tlle kidneys is tisallay mentioned as a contraindicatiol, and Case xr, which died of acute nephritis after two courses of injections, miiolgt be thought to point to this; however, the sylilptoms of neplhritis did not start for more tlhan thlree weeks after the second course wvas colcluded, and tllere had been septic absorption with a septic temperature off and on for more than twelve months.Also in a case of advanced phthisis, wlhen tlle urinie was loadedl with albumen, I gave forty injections on alternate days with no apparent harm to the kidnevs.So, if care is exercised and the injectionis are given every second.dayinstead of daily, even kidniev disease need prove nio insuLperable bar to this metlhod of treatment.In conclusion, I imust acknowledge my indebtedness to Dr. Bernheiin of Paris, who has generously provided me withl the material used .in the treatment of these-cases, anid also to my colleagues at the Royal City of Dublin lIospital, wlho have kindlv allowed Ine to try this mlethod on somue of their patients, and hiave seen alnd examined many of the cases whose history I have brouglht before you to-night.REFE3RENCE .
A COMPARATIVE STUDY OF THE DIPLOCOCCI OCCURRING IN EPIDEMIC CEREBRO-SPINAL MENINGITIS AND POSTERIOR BASIC MENINGITIS
Authors: Martha Wollstein
Journal: The Journal of Experimental Medicine (1909)

The study carried out and recorded in this paper did not lead to the finding of any reliable criteria of difference between strains of Diplococcus intracellularis obtained from typical cases of epidemic meningitis and several cultures obtained from cases of posterior basic meningitis. The successful experiments made with monkeys show that the diplococcus obtained from cases of posterior basic meningitis is capable of setting up rapidly and acutely fatal forms of meningitis and in producing organic lesions of the cerebral tissues of great severity. This study would, therefore, suggest that the antimeningitis serum should be as useful in cases of posterior basic meningitis so-called, as it has been in epidemic meningitis, especially if it were employed early in the disease.
North to Aberdeen — The Age of Maturity — Nurses' Frilly Caps
Authors: John Lister
Journal: New England Journal of Medicine (1969)

THE British Medical Journal1 has admitted that toward the end of June, many doctors were seen carrying golf clubs as they boarded the night trains for Scotland. They were bound for the old granite city of Aberdeen, where the annual meeting of the British Medical Association was being held. No such meeting in Scotland could be complete without a round of golf, and it is feared that during the course of the Conference several hundred balls disappeared forever into the impenetrable rough.But it was not all golf and apart from the scientific and social activities, there was serious discussion . . .
Response to Glasgow
Authors: M. Sue Kirkman, David G. Marrero
Journal: Diabetes Care (2003)

We appreciate Dr. Glasgow’s (1) interest in our article (2) and the opportunity to respond to his comments. He seems to impute a biased worldview to our decision to drop smoking cessation counseling from chart audits subsequent to the baseline audit. First, we can assure him that we were not disinterested in the issue of smoking, as evidenced by the fact that this was one of the areas identified up front as important by the primary care physicians who invited us into their community. Data collection limitations alone drove the decision to drop this measure from subsequent analyses. Our sole source of data for the study was the charts kept by a …
Ether and Chloroform in Convulsions.
Authors: W. F. Rochelle
Journal: JAMA (1890)

<h3>To the Editor:</h3> —On page 835 ofThe Journalfor December 6, chloroform is suggested for convulsions in children, without any word of caution. I have used both chloroform and ether in convulsions of children, and, while I am not sure of any dangerous result from the anæsthetic<i>per se</i>, yet I never give it without extreme caution. The following case is the first of the kind in my practice, and I have not related the case to any one so far who has had a similar experience —therefore I suppose it must be unusual. July the 25th last I was hurriedly called to see a little boy aged 4 years, who had been under treatment for fever and vomiting during the day. I found him in a convulsion which had lasted about four minutes. I noticed nothing unusual about the case, more than we usually see in a child
Abnormal Alveolar Attachments with Decreased Elastic Fiber Content in Distal Lung in Fatal Asthma
Authors: Thais Mauad, Luis F. F. Silva, Mario A. Santos, Lea Grinberg, Fabiola D. C. Bernardi, Milton A. Martins, Paulo H. N. Saldiva, Marisa Dolhnikoff
Journal: American Journal of Respiratory and Critical Care Medicine (2004)

Small airway disease is thought to contribute significantly to functional impairment caused by asthma. Functional evidence of airway-parenchyma uncoupling in asthma, such as loss of deep breath bronchodilator effect in bronchoconstrictive episodes and enhanced airway closure, has been previously demonstrated. Elastic fibers are essential to maintain adequate elastic recoil of the lungs. In this study, we hypothesized that alveolar attachments could be abnormal and that elastic fibers could be damaged in the distal lungs of patients with fatal asthma. For this purpose, we measured the number of abnormal alveolar attachments and quantified the content of elastic fibers in the adventitial layer of small airways and in the peribronchial and distal alveolar septa of 15 patients who died of asthma (FA) and 9 control subjects (CTRL). Our data (geometric mean [range]) showed an increased proportion of abnormal alveolar attachments per centimeter of basement membrane perimeter in fatal asthma (FA, 0.18 [0.03-4.00]; CTRL, 0.00 [0.00-0.12]; p < 0.001) and decreased elastic fiber content in the small airway adventitial layer (FA, 4.08 [2.22-11.46] microm; CTRL, 6.79 [5.62-10.0] microm; p = 0.01) and in the peribronchial alveoli (FA, 1.08 [0.46-1.91] microm; CTRL, 1.81 [1.22-1.74] microm; p = 0.003), but not in the distal alveoli. We propose that structural alterations at the peribronchiolar level might contribute to the pathogenesis of some functional abnormalities observed in patients with severe asthma.
Risk Factors for ICU-Acquired Pneumonia
Authors: Deborah J. Cook
Journal: JAMA (1998)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Early hepatocyte DNA synthetic response posthepatectomy is modulated by IL-6 trans-signaling and PI3K/AKT activation
Authors: Yael Nechemia-Arbely, Anat Shriki, Ulrich Denz, Claudia Drucker, Jürgen Scheller, Jonathan Raub, Orit Pappo, Stefan Rose-John, Eithan Galun, Jonathan H. Axelrod
Journal: Journal of Hepatology (2010)
Biology of the synovial joint.
Authors: P SIMKIN
Journal: Annals of the Rheumatic Diseases (2000)

Two interactive rheumatology tutors on CD-ROMThe widespread availability of information and communication technology oVers new possibilities for education of professionals and of patients.One of these possibilities is computer assisted learning. 1Ten years ago, research focused on the development of computer assisted diagnosis and text based help to rheumatologists and others. 2Despite the initial enthusiasm about artificial intelligence (AI), resulting in several diagnostic expert systems, in routine care a precise diagnosis is rarely an important issue and as a consequence these systems are hardly used.The experience with expert systems, however, evolved into systems intended for educational purposes."AI/Learn", based on the "AI/Rheum" expert system and exploiting a videodisk with an image library, proved to be an eVective means of teaching rheumatology. 3 The same image library was used to teach occupational and physical therapy students with the "HP-Rheum" system (HP: Health Professionals). 4In recent years the introduction of sound, images, and movies on PCs, and the replacement of videodisks by CD-ROM facilitated production and access to these methods.The products resulting from the AI/Rheum project are not yet available on this medium, but two European rheumatologists have now completed educational systems on CD-ROM.They are to be honoured for their pioneering eVorts.The main characteristics of the systems are summarised in table 1, details are discussed below.
TCT-465 Prevalence, Correlation and Clinical Outcome of Intra-procedural Stent Thrombosis in Patients Undergoing Primary Percutaneous Coronary Intervention for Acute Coronary Syndrome
Authors: Yingjia Xu, Xinkai Qu, Xingbiao Qiu, Hui Chen, Shaofeng Guan, Jingjie Dai, Weiyi Fang
Journal: Journal of the American College of Cardiology (2012)
Evening primrose oil and borage oil do not help eczema symptoms, finds Cochrane review
Authors: Z. Kmietowicz
Journal: BMJ (2013)

Evening primrose oil and borage oil do not improve the symptoms of eczema, a review of the evidence has found. Furthermore, both can cause harm, mainly to the gastrointestinal tract. 

The authors, who published their review in the Cochrane Library, concluded that it would be hard to justify further studies on the treatments.1

Some people take evening primrose oil and borage oil because they contain γ linolenic acid, which was once thought to …
Management of Depression in Medical Patients
Authors: Giovanni A. Fava, Nicoletta Sonino, Thomas N. Wise
Journal: Psychotherapy and Psychosomatics (1988)

The management of depression in the medically ill is a complex task that requires considerable clinical skills. The aim of this review is to outline evaluation strategies which may lead to a more effective use of current psychiatric diagnostic criteria and to suggest clinical guidelines for the use of antidepressant medications and psychotherapeutic techniques. The multifactorial determinants and modes of expression of depression in the medical patient require further research. Treatment outcome studies involving drug treatment or short-term psychotherapeutic approaches or both are needed. Antidepressant drugs remain the most specific and readily available treatment of major depressive disorders in the setting of medical disease. In case of organic affective syndromes, treatment should be primarily directed to the physical condition.
Transendothelial insulin transport is not saturable in vivo. No evidence for a receptor-mediated process.
Authors: G M Steil, M Ader, D M Moore, K Rebrin, R N Bergman
Journal: Journal of Clinical Investigation (1996)

In vitro, insulin transport across endothelial cells has been reported to be saturable, suggesting that the transport process is receptor mediated. In the present study, the transport of insulin across capillary endothelial cells was investigated in vivo. Euglycemic glucose clamps were performed in anesthetized dogs (n = 16) in which insulin was infused to achieve concentrations in the physiological range (1.0 mU/kg per min + 5 mU/kg priming bolus; n = 8) or pharmacologic range (18 mU/kg per min + 325 mU/kg priming bolus; n = 8). Insulin concentrations were measured in plasma and hindlimb lymph derived from interstitial fluid (ISF) surrounding muscle. Basal plasma insulin concentrations were twice the basal ISF insulin concentrations and were not different between the physiologic and pharmacologic infusion groups (plasma/ISF ratio 2.05 +/- 0.22 vs 2.05 +/- 0.23; p = 0.0003). The plasma/ISF gradient was, however, significantly reduced at steady-state pharmacologic insulin concentrations (1.37 +/- 0.25 vs 1.98 +/- 0.21; P = 0.0003). The reduced gradient is opposite to that expected if transendothelial insulin transport were saturable. Insulin transport into muscle ISF tended to increase with pharmacologic compared with physiologic changes in insulin concentration (41% increase; 1.37 +/- 0.18 10(-2) to 1.93 +/- 0.24 10(-2) min-1; P = 0.088), while at the same time insulin clearance out of the muscle ISF compartment was unaltered (2.53 +/- 0.26 10(-2) vs 2.34 +/- 0.28 10(-2) min-1; P = 0.62). Thus, the reduced plasma/ISF gradient at pharmacologic insulin was due to enhanced transendothelial insulin transport rather than changes in ISF insulin clearance. We conclude that insulin transport is not saturable in vivo and thus not receptor mediated. The increase in transport efficiency with saturating insulin is likely due to an increase in diffusionary capacity resulting from capillary dilation or recruitment.
A predominant role for the HLA class II region in the association of the MHC region with multiple sclerosis
Authors: Matthew R Lincoln, Alexandre Montpetit, M Zameel Cader, Janna Saarela, David A Dyment, Milvi Tiislar, Vincent Ferretti, Pentti J Tienari, A Dessa Sadovnick, Leena Peltonen, George C Ebers, Thomas J Hudson
Journal: Nature Genetics (2005)
Cuffed Gastric Tube for Neonatal Respiratory Resuscitation
Authors: H. A. L. Wagner
Journal: BMJ (1966)

Hg, the pulse remaining about 60 per minute throughout.At this stage he fell asleep.Although his blood-pressure continued to rise slowly, it did not regain the pre-operative figure for 36 hours.Eleven days later (15 days after discontinuing phenelzine) and following the same premedication, his retinal detachment was operated on, this time without any hypo- tensive episodes.Though the patient was also taking perphenazine for an equal time, it is considered that the phenelzine, with its known action in potentiating other drugs, was the agent responsible.-Iam, etc.,
INTRAPERITONEAL HEMORRHAGE FROM RUPTURED OVARIAN CYST
Authors: LOUIS E. PHANEUF
Journal: JAMA (1924)

Clinically, ovarian hematomas are divided into four well recognized types: the large ovarian cysts with hemorrhagic contents due to twisting of the pedicle of the cyst or other conditions; the perforating hemorrhagic (chocolate) cysts of the ovary so well described by Sampson, and the follicular and corpus luteum cysts of the ovary which on their rupture may give rise to severe intraperitoneal hemorrhage. The first type, as a rule, does not give rise to intraabdominal hemorrhage; the second type likewise gives rise to but little bleeding in the peritoneal cavity, since the perforation in the cyst becomes readily sealed by becoming adherent to the peritoneum of the pelvis or to the adjacent organ with which it comes in contact. It is therefore with the third and the fourth types, or the follicular and the corpus luteum cysts with rupture, causing intraperitoneal hemorrhage, that I wish to deal in this paper.