tbuckley/cabot-search huggingface dataset:
Old age in the sun.
Authors: T Smith
Journal: BMJ (1984)

In 1984 Australia's culture and its social structure are as much influenced by the United States as by Britain. The fast food restaurants, the drive in movie theatres, and the large, slowly driven cars give the visitor the impression that he might be in the American midwest (until someone starts speaking) ; and for many Australians the profusion of advertising and cut price promo? tions reflect the healthy virtues of capitalism. Yet the Labour party is in office, and successive governments have accepted responsibility for a wide ranging programme of social welfare. Australia's health system?and especially its arrangements for the care of the elderly?provide a prime example of the in? compatibility of social welfare and entrepreneurial capitalism when brought together in a marriage of convenience. The British influence seen in Australia should not be equated with attitudes found in contemporary Britain. Many Australian doctors emigrated from Britain after the second world war, disenchanted with socialism and austerity. They remain strongly opposed to any suggestion of socialised medicine on the NHS pattern: the Australian Medical Association speaks the same language (and has the same public image) as the American Medical Association. Doctors are seen by politicians and the public as rich, powerful, and greedy, though individual patients often have the same affection and respect for their family doctors as in Britain. At present the doctors and the government are enmeshed in bitter arguments about the financial implications for patients and doctors of plans for a new system of compulsory health insurance. Medicare. This is the context in which care of the elderly reflects the continuing conflict between society's aspirations for compassionate provision for their needs and the ingrained opposition of many doctors and businessmen to what they see as governmental interference. Australia has not escaped the worldwide economic recession and its economists share the conviction of those in Europe and the United States that public spending should be cut?and that includes spending on the elderly. The current financial crisis has focused public attention on the rapid growth in the past decade of the numbers of nursing homes and other institutions for the elderly. Many of these institutions are run as money making businesses, but most of the occupants' fees are paid by the government. Attempts by the government to grapple with this drain on its finances have run into two obstacles : the conserva? tism of the medical profession and the Australian tradition that making money fast is a virtue. And to complicate the story further for the overseas visitor Australia is made up of six autonomous states and two territories, each of which has a slightly different system for the care of old people while much of the money that pays for that care comes from taxation controlled by the Commonwealth (federal) government.
ASSOCIATION BETWEEN QTC INTERVAL DURATION AND THE RISK OF ARRHYTHMIA RECURRENCE AFTER CATHER ABLATION OF PAROXYSMAL ATRIAL FIBRILLATION
Authors: Xiao-Yan Wu, Nian Liu, Rong Bai, Song-Nan Li, Xin Du, Jianzeng Dong, Chang-Sheng Ma
Journal: Journal of the American College of Cardiology (2015)
Periodontopathogen profile of healthy and oral lichen planus patients with gingivitis or periodontitis
Authors: Abdullah Seckin Ertugrul, Ugur Arslan, Recep Dursun, Sema Sezgin Hakki
Journal: International Journal of Oral Science (2013)

Oral lichen planus (OLP) is a chronic inflammatory disease that is frequently detected in oral tissues. The aim of our study was to identify the prevalence of the detection of periodontopathogenic microorganisms (Aggregatibacter actinomycetemcomitans, Porphyromonas gingivalis, Prevotella intermedia, Tannerella forsythia and Treponema denticola in OLP patients and to compare with this prevalence of periodontopathogenic microorganisms in healthy non-OLP patients. Our study included 27 (18 chronic periodontitis (OLPP) and 9 gingivitis (OLPG)) patients diagnosed with OLP along with 26 (13 chronic periodontitis (HP) and 13 gingivitis (HG)) healthy non-OLP patients. The multiplex polymerase chain reaction (PCR) with subsequent reverse hybridization method (micro-IDent) was used for identifying periodontopathogenic microorganisms present in subgingival plaque samples. The percentages of detection for A. actinomycetemcomitans, P. gingivalis, P. intermedia, T. forsythia and T. denticola in subgingival plaque samples taken from OLP patients (OLPG and OLPP) were 18.5%, 85.1%, 81.4%, 88.8% and 74%, respectively. Meanwhile, in the non-OLP patients (HG and HP), these values were 7.6%, 50%, 46.1%, 73% and 57.7%, respectively. Thus, comparing the non-OLP groups with the OLP groups, the periodontopathogens' percentages of detection in the OLP groups were higher than those in the non-OLP groups. According to our study results, OLP patients have higher levels of infection with A. actinomycetemcomitans, P. gingivalis, P. intermedia, T. forsythia and T. denticola than non-OLP patients. We argue that the high percentages in patients with OLP may help identify the importance of periodontopathogenic microorganisms in the progress of periodontal diseases of OLP. Patients with oral lichen planus (OLP) have higher rates of infection with microbes that cause periodontal disease, researchers in Turkey have shown. The findings could help to explain the causes of this poorly understood chronic inflammatory condition that produces red or lacy white lesions in the mouth. Researchers had characterized the association between OLP and infection with herpes-family viruses, but not with pathogenic bacteria. Abdullah seckin Ertugrul of the Yuzuncu Yil University and co-workers used genetic methods, which can identify anaerobic bacteria more efficiently than culturing, to screen the microbes in plaque samples from patients with OLP and without the condition. The OLP patients had significantly higher rates of infection with pathogens such as Porphyromonas gingivalis and Treponema denticola. The authors recommend long-term studies to investigate whether these microbes play a direct role in causing OLP.
Upregulation of Estradiol C16 -hydroxylation in Human Breast Tissue: a Potential Biomarker of Breast Cancer Risk
Authors: M. P. Osborne, H. L. Bradlow, G. Y. C. Wong, N. T. Telang
Journal: JNCI Journal of the National Cancer Institute (1993)

Journal Article Upregulation of Estradiol C16α-hydroxylation in Human Breast Tissue: a Potential Biomarker of Breast Cancer Risk Get access Michael P. Osborne, Michael P. Osborne Strang-Cornell Cancer Research Laboratory, Strang Cancer Prevention Center, and Cornell University Medical CollegeNew York, N.Y. Correspondence to : Nitin T. Telang, Ph.D., Division of Carcinogenesis & Prevention, Strang-Cornell Cancer Research Laboratory, 510 East 73rd St. (2nd Floor), New York, NY 10021. Search for other works by this author on: Oxford Academic PubMed Google Scholar H. Leon Bradlow, H. Leon Bradlow Strang-Cornell Cancer Research Laboratory, Strang Cancer Prevention Center, and Cornell University Medical CollegeNew York, N.Y. Search for other works by this author on: Oxford Academic PubMed Google Scholar George Y. C. Wong, George Y. C. Wong Strang-Cornell Cancer Research Laboratory, Strang Cancer Prevention Center, and Cornell University Medical CollegeNew York, N.Y. Search for other works by this author on: Oxford Academic PubMed Google Scholar Nitin T. Telang Nitin T. Telang Strang-Cornell Cancer Research Laboratory, Strang Cancer Prevention Center, and Cornell University Medical CollegeNew York, N.Y. * See “Notes” section following “References.” Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 85, Issue 23, 1 December 1993, Pages 1917–1920, https://doi.org/10.1093/jnci/85.23.1917 Published: 01 December 1993 Article history Received: 18 May 1993 Revision received: 31 August 1993 Accepted: 07 September 1993 Published: 01 December 1993
Aspirin and Hepatotoxicity: Addendum
Authors: WILLIAM E. SEAMAN
Journal: Annals of Internal Medicine (1974)

Comments and Corrections1 February 1974Aspirin and Hepatotoxicity: AddendumWILLIAM E. SEAMAN, M.D., KAMAL G. ISHAK, M.D., PH.D., PAUL H. PLOTZ, M.D.WILLIAM E. SEAMAN, M.D.Search for more papers by this author, KAMAL G. ISHAK, M.D., PH.D.Search for more papers by this author, PAUL H. PLOTZ, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-80-2-279_1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: We wish to add the following note to our paper on aspirin-induced hepatotoxicity in the January issue (Ann Intern Med 80:1-8, 1974).Patient 3 had a flare of her lupus erythematosus 5 months after stopping aspirin therapy, despite therapy with prednisone and acetaminophen. A repeat liver biopsy was normal. Aspirin therapy was reinstituted, 2.4 g per day, but 2 weeks later the transaminase levels were again elevated. They returned to normal when aspirin was stopped.... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: National Institutes of Health Bethesda, Maryland PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByEffect of aspirin on liver tests in patients with ra or sle and in normal volunteersAspirin HepatotoxicityANGELA M. HILTON, M.B., CH.B., M.R.C.P. (U.K), I. W. DYMOCK, M.B., M.R.C.P. ED., F.R.C.P. (GLASG) 1 February 1974Volume 80, Issue 2Page: 279-279KeywordsAminotransferasesAspirinBiopsyLiverLupus erythematosus Issue Published: 1 February 1974 PDF DownloadLoading ...
Endoscopy-Assisted Placement of a Crosby Capsule by a New Method: Results of a Preliminary Study
Authors: G. Öksüzoğlu, B. Sivri, A. Kadayifci, Y. Bayraktar, S. Arslan, G. Tatar, H. Şimşek, M. Arslan, B. Kayhan
Journal: Endoscopy (1997)
Surgery of ventricular septal defect and pulmonary vascular resistance
Authors: H. A. Samaan
Journal: Thorax (1970)

In a series of 65 patients operated upon for ventricular septal defects (VSD), no mortality was attributed to pre-operative raised pulmonary vascular resistance. Eight patients with a severe degree of pulmonary vascular resistance made a full recovery after surgical closure of the ventricular septal defect. Three patients were cyanotic at the time of operation. Mortality in the series was the result of inadequate perfusion during operation, haemorrhage, cardiac tamponade, mediastinal infection, complete heart block or the development of post-operative aortic incompetence. Raised pulmonary vascular resistance and clinical evidence of a dominant left-to-right shunt in the absence of serious intracardiac anatomical complications does not contraindicate surgery for the repair of VSD.
Colonial Psychiatry and "The African Mind"
Authors: M. Lipsedge
Journal: BMJ (1996)

Jock McCulloch Cambridge University Press, £35, pp 185 ISBN 0 521 45330 5

Adistrict medical officer who became superintendent at Mathari Mental Hospital in Nairobi, J C Carothers was the most prolific and influential of the ethnopsychiatrists—those mental health practitioners who, between 1900 and 1960, regarded themselves as authorities on the psychology and behaviour of African people. In addition to Carothers, they included the white South Africans D J F Laubscher and Wulf Sachs, the French Algerian Porot, and the Martiniquean Frantz Fanon, who worked for the French administration in Algeria before defecting to the liberation movement in 1955.

The subjects of ethnopsychiatry were African patients in the psychiatric hospitals sited in the new cities, where asylums had been set up originally as annexes of the prisons. In Colonial Psychiatry and “The African …
Smap1 deficiency perturbs receptor trafficking and predisposes mice to myelodysplasia
Authors: Shunsuke Kon, Naoko Minegishi, Kenji Tanabe, Toshio Watanabe, Tomo Funaki, Won Fen Wong, Daisuke Sakamoto, Yudai Higuchi, Hiroshi Kiyonari, Katsutoshi Asano, Yoichiro Iwakura, Manabu Fukumoto, Motomi Osato, Masashi Sanada, Seishi Ogawa, Takuro Nakamura, Masanobu Satake
Journal: Journal of Clinical Investigation (2013)

The formation of clathrin-coated vesicles is essential for intracellular membrane trafficking between subcellular compartments and is triggered by the ARF family of small GTPases. We previously identified SMAP1 as an ARF6 GTPase-activating protein that functions in clathrin-dependent endocytosis. Because abnormalities in clathrin-dependent trafficking are often associated with oncogenesis, we targeted Smap1 in mice to examine its physiological and pathological significance. Smap1-deficent mice exhibited healthy growth, but their erythroblasts showed enhanced transferrin endocytosis. In mast cells cultured in SCF, Smap1 deficiency did not affect the internalization of c-KIT but impaired the sorting of internalized c-KIT from multivesicular bodies to lysosomes, resulting in intracellular accumulation of undegraded c-KIT that was accompanied by enhanced activation of ERK and increased cell growth. Interestingly, approximately 50% of aged Smap1-deficient mice developed anemia associated with morphologically dysplastic cells of erythroid-myeloid lineage, which are hematological abnormalities similar to myelodysplastic syndrome (MDS) in humans. Furthermore, some Smap1-deficient mice developed acute myeloid leukemia (AML) of various subtypes. Collectively, to our knowledge these results provide the first evidence in a mouse model that the deregulation of clathrin-dependent membrane trafficking may be involved in the development of MDS and subsequent AML.
A bridge over troubled waters
Authors: Piyal Sen
Journal: BMJ (2007)

The Golden Gate Bridge in San Francisco is one of the world's greatest tourist destinations. It is also, however, one of the most popular suicide locations. More than 13 000 people have killed themselves by jumping from the bridge since it opened in 1937. Amazingly, despite such startling evidence, no suicide barrier has ever been erected. The reasons put forward have included concerns about engineering, effectiveness, cost, and aesthetics.



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This in the country that perhaps attributes the highest cost to human life and in one of its wealthiest and most liberal states, California.

The Bridge focuses on suicide as a public health issue. There are almost twice as many suicides in the United States as there are homicides, yet the public focus remains firmly on homicide and the “moral panic” surrounding it. A particularly worrying trend in all industrialised nations is the disproportionately high rate of suicide among young …
SB1518, a novel macrocyclic pyrimidine-based JAK2 inhibitor for the treatment of myeloid and lymphoid malignancies
Authors: S Hart, K C Goh, V Novotny-Diermayr, C Y Hu, H Hentze, Y C Tan, B Madan, C Amalini, Y K Loh, L C Ong, A D William, A Lee, A Poulsen, R Jayaraman, K H Ong, K Ethirajulu, B W Dymock, J W Wood
Journal: Leukemia (2011)

SB1518 is an innovative pyrimidine-based macrocycle that shows a unique kinase profile with selective inhibition of Janus Kinase-2 (JAK2; IC50=23 and 19 nM for JAK2WT and JAK2V617F, respectively) within the JAK family (IC50=1280, 520 and 50 nM for JAK1, JK3 and TYK2, respectively) and fms-like tyrosine kinase-3 (FLT3; IC50=22 nM). SB1518 shows potent effects on cellular JAK/STAT pathways, inhibiting tyrosine phosphorylation on JAK2 (Y221) and downstream STATs. As a consequence SB1518 has potent anti-proliferative effects on myeloid and lymphoid cell lines driven by mutant or wild-type JAK2 or FLT3, resulting from cell cycle arrest and induction of apoptosis. SB1518 has favorable pharmacokinetic properties after oral dosing in mice, is well tolerated and significantly reduces splenomegaly and hepatomegaly in a JAK2V617F-driven disease model. SB1518 dose-dependently inhibits intra-tumor JAK2/STAT5 signaling, leading to tumor growth inhibition in a subcutaneous model generated with SET-2 cells derived from a JAK2V617F patient with megakaryoblastic leukemia. Moreover, SB1518 is active against primary erythroid progenitor cells sampled from patients with myeloproliferative disease. In summary, SB1518 has a unique profile and is efficacious and well tolerated in JAK2-dependent models. These favorable properties are now being confirmed in clinical studies in patients with myelofibrosis and lymphoma.
Review of C. B. Mitchell, E. D. Pellegrino, J. B. Elshtain, J. F. Kilner, and S. B. Rae.<i>Biotechnology and the Human Good</i>.<sup>1</sup>
Authors: Lauris Christopher Kaldjian
Journal: The American Journal of Bioethics (2008)

Biotechnology has made profound contributions to human health, and expectations for its future potential are ever expanding. But hopes for a continued harvest of gains against disease and disabilit...
Portal and splenic vein occlusion complicating Histoacryl injection therapy in bleeding gastric varices
Authors: W. Thijs, E. de Groot, L. Hofstra
Journal: Endoscopy (2008)

Endoscopic injection therapy with n-butyl-2-cyanoacrylate (NBCA) (Histoacryl®, B. Braun, Melsungen, Germany) is an effective hemostatic treatment for gastric variceal bleeding [1]. In this report we describe a case of portal and splenic vein occlusion after injection therapy with NBCA.
Changes in the expression of potassium channels during mouse T cell development.
Authors: D McKinnon, R Ceredig
Journal: The Journal of Experimental Medicine (1986)

In this report we have combined the whole-cell electrophysiological recording technique with flow microfluorometry to isolate phenotypically defined thymocytes and T lymphocytes. Results obtained showed that J11d-/Lyt-2-/L3T4- cells express none or very few delayed rectifier K+ channels, whereas most other Lyt-2-/L3T4- cells, as well as typical cortical thymocytes (Lyt-2+/L3T4+), do express K+ channels. Mature (Lyt-2+/L3T4- or Lyt-2-/L3T4+) thymocytes, which are heterogeneous for J11d expression, were also found to be heterogeneous for K+ channel expression. Consistent with this finding was the observation that the cortisone-resistant subpopulation of thymocytes, which express low levels of J11d, were enriched for cells expressing low levels of K+ channels. Mature phenotype peripheral T lymphocytes expressed very low levels of K+ channels, but upon activation with Con A were found to express high levels of K+ channels. The results suggest that K+ channel expression in T cells is developmentally regulated. Increased expression of the channel is induced in response to mitogenic signals throughout the T cell lineage. Expression of the channel, therefore, serves as a useful marker in defining steps in the T cell differentiation pathway.
Invasive <i>Haemophilus influenzae</i> Disease in Adults
Authors: Monica M. Farley, David S. Stephens, Philip S. Brachman, R. Christopher Harvey, J. David Smith, Jay D. Wenger
Journal: Annals of Internal Medicine (1992)

To define the incidence of and possible risk factors for invasive Haemophilus influenzae disease in adults.Prospective, population-based surveillance of hospital and referral bacteriology laboratories.Metropolitan Atlanta, Georgia community.All patients with H. influenzae isolated from normally sterile sites (blood, cerebrospinal fluid, joint, pleura) from 1 December 1988 through 31 May 1990.Isolates of H. influenzae were analyzed for serotype and biotype status, outer membrane proteins, lipooligosaccharide phenotypes, ribotyping patterns and beta-lactamase production.A total of 194 cases of invasive H. influenzae occurred (annual incidence of 5.6 cases/100,000 population), of which 47 (24%) were in adults 18 years old or older (annual incidence 1.7 cases/100,000 adults). Adults with invasive H. influenzae ranged from 18 to 96 years; 79% were women. Bacteremic pneumonia accounted for 70% of the adult cases. Other sources for invasive H. influenzae in adults were obstetric infections, epiglottitis, and tracheobronchitis; one patient had meningitis. Underlying conditions were noted in 92% of the patients. Chronic lung disease was the most common risk factor, but pregnancy (annual incidence, 4.9/100,000 pregnant women), HIV infection (annual incidence, 41/100,000 known HIV-infected adults), and malignancy were also important. Overall mortality was 28% in adults, and over half of pregnancy-related infections resulted in fetal death. Fifty percent of the 40 isolates available for testing were serotype b; 47.5%, nontypable; and 2.5%, serotype f. Sixteen of the 45 isolates (36%) were ampicillin-resistant. Based on biotypes, outer membrane protein profiles, lipooligosaccharide phenotypes, and ribotyping patterns, the type b isolates showed less heterogeneity than the nontypable isolates but were distinguishable from one another.Adult cases currently represent one quarter of all cases of invasive H. influenzae disease. Half of the reported adult cases were caused by type b H. influenzae, and the rate of ampicillin resistance in H. influenzae isolates from adults was higher than previously reported. Haemophilus influenzae is an important cause of bacteremia in compromised adults.
Biliary excretion and enterohepatic circulation of thienorphine and its glucuronide conjugate in rats
Authors: Jingting Deng, Xiaomei Zhuang, Guolin Shen, Hua Li, Zehui Gong
Journal: Acta Pharmaceutica Sinica B (2012)

Thienorphine (TNP) is a new partial opioid agonist currently developed as a promising drug candidate with the intended clinical indication for the treatment of opioid dependence. The pharmacokinetic profile and biliary excretion of TNP and its glucuronide conjugate (TNP-Glu) were investigated after oral administration of TNP in rats. The concentrations of TNP and TNP-Glu were simultaneously quantified using a LC-MS/MS method. A double peak phenomenon was observed in TNP plasma concentration–time curves with the secondary peak appeared at 6–8 h. A slower decline of plasma concentrations in the terminal phase was observed for TNP with T1/2 of 7.01 h. TNP-Glu was the predominant component in rat plasma and bile. Its plasma level was about 10 times higher than TNP and the 24 h accumulative bile excretion rate was 23%. Enterohepatic circulation of TNP and TNP-Glu was evaluated using a paired rat model. In bile-donor rats, no double-peak was detected and the elimination half life of TNP was significantly shortened (3.71 h) when compared to intact rats (7.01 h, P<0.05). Both TNP and TNP-Glu were detected in bile-recipient rats. Their exposures in recipient rats due to enterohepatic circulation were 15.6% and 42.6% for the parent drug and the metabolite, respectively. The deconjugation of the glucuronide conjugate and the reabsorption of free TNP were further confirmed in in situ perfused rat intestinal preparations. These results indicate that the enterohepatic circulation has a significant influence on the systemic exposure of the parent drug and its glucuronide conjugate, particularly on the terminal elimination of TNP, which may result in the prolonged retention of the drug in body.
PYREXIA DUE TO INFECTED DEAD TEETH
Authors: L. G. J. MacKey
Journal: BMJ (1928)

Apart from the rarity of laryngeal diphtheria. in advanced life the case is of interest in the follow-ing respects.The pernicious doctrine which has received support in two of the most recenit textbooks on diseases of the throat-that anititoxin is of no value after the fiftlh day of disease-is falsified by the rapid subsidence of the symptoms after injection of the large doses which the patient receiv-ed.The abselnce of any serum reaction was due partly to the use of a refined serum and partly to the fact, wlich I have illustrated on several previous occasionis, that serulm reactions are often absenit or ill maiked after severe angina in spite of-the a(lministratioin of 1arge amounts of serum.Recovery was all the more remarkable as the progniosis of larvngeal diphtlheria in adult life is usuially unii- favourable.Lastly the case is an excellent example of what C. Zoeller,3 who has recently recorded an attack of laryngeal diphtheria in a middle-aged man, describes as the " caprices of spontanieouis immunization."