tbuckley/cabot-search huggingface dataset:
Sequence variations in the collagen IX and XI genes are associated with degenerative lumbar spinal stenosis
Authors: N Noponen-Hietala
Journal: Annals of the Rheumatic Diseases (2003)

<b>Background:</b> Degenerative lumbar spinal stenosis (LSS) is usually caused by disc herniation or degeneration. Several genetic factors have been implicated in disc disease. Tryptophan alleles in COL9A2 and COL9A3 have been shown to be associated with lumbar disc disease in the Finnish population, and polymorphisms in the vitamin D receptor gene (VDR) (<i>Fok</i>I and <i>Taq</i>I), the matrix metalloproteinase-3 gene (MMP-3) and an aggrecan gene (AGC1) VNTR have been reported to be associated with disc degeneration. In addition, an IVS6-4 a&gt;t polymorphism in COL11A2 has been found in connection with stenosis caused by ossification of the posterior longitudinal ligament in the Japanese population. <b>Objective:</b> To study the role of genetic factors in LSS. <b>Methods:</b> 29 Finnish probands were analysed for mutations in the genes coding for intervertebral disc matrix proteins, COL1A1, COL1A2, COL2A1, COL9A1, COL9A2, COL9A3, COL11A1, COL11A2, and AGC1. VDR and MMP-3 polymorphisms were also analysed. Sequence variations were tested in 56 Finnish controls. <b>Results:</b> Several disease associated alleles were identified. A splice site mutation in COL9A2 leading to a premature translation termination codon and the generation of a truncated protein was identified in one proband, another had the Trp2 allele, and four others the Trp3 allele. The frequency of the COL11A2 IVS6<sup>−4</sup> t allele was 93.1% in the probands and 72.3% in controls (p = 0.0016). The differences in genotype frequencies for this site were less significant (p = 0.0043). <b>Conclusions:</b> Genetic factors have an important role in the pathogenesis of LSS.
Malignant pleural mesothelioma
Authors: H Schouwink, P Baas, ET Rutgers, FA Zoetmulder
Journal: European Respiratory Journal (1999)

Malignant mesothelioma (MM) has recently attracted the attention of the media because of its relationship with professional and environmental exposure to asbestos. This tumour of the pleura is a disease which has emerged in significant numbers of patients during the last 30 years in the industrialized countries, and its increasing incidence makes it of socio-economical interest. The histological description of MM was first published by E. Wagner in 1870 [1] and later by Klemperer and Rabin [2]. A literature review of pathological cases of lung diseases before 1940 identified 41 out of 46,000 autopsies as possible MM [3]. In this review they mentioned a report from 1767 by Lieutaud who was the first to describe two possible cases of MM in an autopsy study. Since then a number of case reports [4-6] were published in which a relationship with asbestos exposure was considered important but it was the report of J. C. Wagner in 1960 which identified a clear relationship between exposure to crocidolite mining and the development of MM [7]. From that moment the association between asbestos exposure and MM was accepted and a beginning was made to abandon the production and processing of asbestos material.
IL-17 Enhances Tumor Development in Carcinogen-Induced Skin Cancer
Authors: Lin Wang, Tangsheng Yi, Wang Zhang, Drew M. Pardoll, Hua Yu
Journal: Cancer Research (2010)

Abstract Inflammatory conditions elicited by extrinsic environmental factors promote malignant cell transformation, tumor growth, and metastasis. Although most attention has been focused on innate immune mechanisms of inflammatory carcinogenesis, more recently the role of T cells in cancer promotion has been examined. Although IFN-dependent Th1 responses that promote Stat1 signaling inhibit tumor growth, the role of T helper type 17 responses, and interleukin-17 (IL-17) in particular, has been controversial. Indeed, IL-17 has been reported to either enhance or inhibit the growth of transplantable tumors, depending on the system. Little is known about the role of IL-17 in de novo carcinogenesis. Using IL-17 knockout mice, we examined the role of IL-17 in the classic DMBA/TPA-induced skin carcinogenesis model. Disruption of IL-17 dramatically reduced tumorigenesis in this model in a manner correlated with diminished Stat3 activation in the tumor microenvironment. IL-17 loss reduced Stat3-associated proliferative and antiapoptotic gene expression along with epidermal cell proliferation and hyperplasia. In addition, IL-17 loss was associated with reduced expression of Stat3-regulated chemokines that attract myeloid cells and a decreased infiltration of myeloid cells into the local tumor microenvironment. Together, our findings point to a critical role of the IL-17–Stat3 pathway in supporting cancer-associated inflammation in the tumor microenvironment. Therapeutic approaches that target this pathway may therefore be effective to inhibit carcinogenesis. Cancer Res; 70(24); 10112–20. ©2010 AACR.
Abstract 3789: Elevated inorganic phosphate stimulates immediate early gene expression and requires FGF receptor signaling
Authors: George R. Beck, Corinne E. Camalier, Brian Hood, Thomas P. Conrads
Journal: Cancer Research (2010)

Abstract Dietary inorganic phosphate represents a novel chemoprevention target. Recent results from two different mouse models of tumorigenesis; the two-stage skin carcinogenesis and KrasLA1 lung tumor models suggest that a high phosphate diet increases tumor/papilloma number by approximately 50% relative to a low phosphate diet. Additionally, a low phosphate diet resulted in delayed incidence and growth of papillomas. These results suggest that increased consumption of dietary inorganic phosphate may have long-term consequences on overall health and particularly to tumorigenesis and consequently reducing dietary phosphate intake may be a novel chemoprevention strategy. Our in vitro studies have revealed an active role of inorganic phosphate in altering cell function in various cell types and suggest that the amount of available inorganic phosphate may have significant cell autonomous consequences on cell behavior including activation of ras and ERK1/2 signaling, and increased expression of transformation and metastasis associated genes such as osteopontin (spp1). However, the mechanism by which cells sense and respond to changes in extracellular phosphate resulting in increased proliferation and transformation is not fully understood. We have performed an analysis of the temporal changes in gene expression in response to elevated phosphate. Results identified the strong stimulation of immediate early genes within 15 minutes of exposure to elevated phosphate. Reporter and DNA binding assays revealed the requirement of serum response and AP-1 transcriptional elements and taken together characterize phosphate as a novel mitogen. Furthermore, we have identified the requirement of FGF receptor signaling as one of the earliest events in the phosphate signaling cascade. This finding provides a novel link between growth factor signaling, nutrient sensing and cell growth and tumorigenesis. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 101st Annual Meeting of the American Association for Cancer Research; 2010 Apr 17-21; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2010;70(8 Suppl):Abstract nr 3789.
Neonatal and "perinatal" mortality rates by birth weight.
Authors: R R Gordon
Journal: BMJ (1977)

Neonatal and "perinatal" mortality rates by birth weight were compared for Sheffield and for England and Wales. The fall in neonatal mortality rate for Sheffield infants weighing 2500 g or less was partly due to the excessive fall in numbers in the 1000 g or less group: this effect was also present in England and Wales but was less pronounced. Perinatal mortality rates may be lowered either by reducing (a) the number of stillbirths, (b) the number of preterm live births, or (c) by salvaging a greater percentage of the latter. For liveborn births it is suggested that the second approach would be better than the third. So far there is no evidence that superintensive care for those weighing 1000 g or less reduces their mortality rate.
White fibrous papulosis of the neck
Authors: R.K. JOSHI, A. ABANMI, A. HALEEM
Journal: British Journal of Dermatology (1992)

We report two middle-aged women who presented with multiple, discrete, non-follicular, oval, pale, asymptomatic lesions on the neck. Clinical and histopathological features were compatible with the entity of white fibrous papulosis of the neck.
Genetic Approaches to Cardiovascular Disease
Authors: Mark T. Keating
Journal: Circulation (1995)

Although family history can be an important risk factor for cardiovascular disease, relatively little is known about the nature of specific genetic risk factors. One approach to this problem is to identify and characterize genes responsible for inherited disorders in the hope that this information will also provide mechanistic insight into common forms of cardiovascular disease.Over the last decade, it has become possible to identify genes that cause human disease by use of the techniques of molecular genetics, specifically genetic linkage analysis, positional cloning, and mutational analyses. We have used these techniques to study three inherited cardiovascular disorders: supravalvular aortic stenosis, Williams syndrome, and long-QT syndrome. We have discovered that the vascular pathology of supravalvular aortic stenosis and Williams syndrome results from mutations involving the elastin gene on chromosome 7q11.23. These mutations include intragenic deletions, translocations, and complete deletion of the elastin gene, suggesting that a quantitative reduction in elastin during vascular development is pathogenically important. To date, only the elastin gene has proved important for supravalvular aortic stenosis. By contrast, genetic linkage analyses in families with long-QT syndrome indicate that at least four distinct genes can cause this disorder. We have identified three LQT loci: LQT1 on chromosome 11p15.5, LQT2 on 7q35-36, and LQT3 on 3p21-24. Recently, we demonstrated that mutations in a putative cardiac potassium channel gene, HERG, are responsible for the chromosome 7-linked form of long-QT syndrome, whereas mutations in the cardiac sodium channel gene SCN5A cause the chromosome 3-linked form of this disorder. HERG mutations and potassium channel biophysics suggest a dominant-negative molecular mechanism and reduced repolarization currents. By contrast, SCN5A mutations probably cause subtle alterations of cardiac sodium channel function and prolonged depolarizing currents.Molecular genetic analyses of long-QT syndrome, supravalvular aortic stenosis, and Williams syndrome have begun to unravel the mechanisms underlying these inherited disorders. Rapid genetic testing for Williams syndrome is now available using a simple cytogenetic test, fluorescence in situ hybridization, but additional work will be required for long-QT syndrome and autosomal-dominant supravalvular aortic stenosis. Improved diagnosis and mechanistic understanding of these disorders should lead to rational treatment and prevention.
Exercise therapy 'rediscovered' for diabetes, but what does it do?
Authors: Elizabeth Rasche González
Journal: JAMA (1979)

Ancient wisdom has it that physical activity is good for diabetic patients—at least those who are not ketotic or severely deficient in insulin. Celsus first advocated exercise as a component of diabetes management around the time of Christ (<i>Diabetes</i>28 [suppl 1]:107-110, 1979). But in the 1970s, says Fred Whitehouse, MD, past president of the American Diabetes Association, "exercise is being rediscovered as an important modality of treatment in diabetes by scientists who now need to identify<i>how</i>it works." One rediscoverer of exercise who discussed his findings at the recent American Diabetes Association meeting in Los Angeles was Philip Felig, MD, professor of medicine and chief of endocrinology at the Yale University School of Medicine, New Haven, Conn. According to Felig, he and his associates subjected six nonobese, sedentary, normal subjects to a six-week training program consisting of bicycle exercise for one hour per day, four days per week.
Trial of Nurse Practitioners
Authors: RICHARD J. MORRIS
Journal: Annals of Internal Medicine (1974)

Comments1 July 1974Trial of Nurse PractitionersRICHARD J. MORRIS, M.D.RICHARD J. MORRIS, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-81-1-123 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: I find it interesting that Sackett and colleagues made the analogy between their study (The Burlington Trial of The Nurse Practitioner: Health Outcomes of Patients (Ann Intern Med 80:137-142, 1974) and a trial of a pharmacologic agent. I am quite certain that if they had indeed been testing a drug, major methodological changes would have been required for publication. Several defects should be noted.In their assessment of physical function, the authors do not include any indexes that would reflect mild or even moderate decline in function of the major organ systems, which ordinarily wouldnotbe...Reference References1. KESSNERKALK DC (editors): A Strategy For Evaluating Health Services. Washington, D.C., Institute of Medicine, National Academy of Sciences, 1973 Google Scholar1. SPITZERSACKETTSIBLEY WDJ: The Burlington randomized trial of the nurse practitioner. Methods and principal results. N Engl J Med 290:251-256, 1974 CrossrefMedlineGoogle Scholar2. KINLENDOLL LR: Trends in mortality from cancer of the uterus in Canada and in England and Wales. Br J Prev Soc Med 27:146-149, 1973 MedlineGoogle Scholar3. ELWOODWOOD PM: Effect of oral iron therapy on the symptoms of anemia. Br J Prev Soc Med 20:172-175, 1966 MedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: RICHARD J. MORRIS, M.D.Affiliations: Department of Medicine Strong Memorial Hospital University of Rochester School of Medicine Rochester, New York 14642 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited bySilicon Nitride as Mask and Dielectric in Field Effect Devices 1 July 1974Volume 81, Issue 1Page: 123-124KeywordsDrugsNursesPhysical functioning ePublished: 1 December 2008 Issue Published: 1 July 1974 PDF downloadLoading ...
Differentiation therapy for the treatment of t(8;21) acute myeloid leukemia using histone deacetylase inhibitors
Authors: Michael Bots, Inge Verbrugge, Benjamin P. Martin, Jessica M. Salmon, Margherita Ghisi, Adele Baker, Kym Stanley, Jake Shortt, Gert J. Ossenkoppele, Johannes Zuber, Amy R. Rappaport, Peter Atadja, Scott W. Lowe, Ricky W. Johnstone
Journal: Blood (2014)
Beyond the Bench: Tracking Clues with Environmental Health Sleuths
Authors: Tanya Tillett
Journal: Environmental Health Perspectives (2006)

Moving On in VietnamWar and unrest mark the history of Vietnam.For hundreds of years, Vietnam has fought a number of foreign invaders including the French, Japanese, and Chinese.The U.S.-Vietnam War was just one of several chapters in this history, ending in 1973 with the Paris Peace Accords.The American War, as it is referred to in Vietnam, has been estimated to have resulted in the deaths of 1.5 million Vietnamese and 58,000 Americans.The countryside is still dotted by unexploded mines, and questions remain about environmental health concerns such as the lasting effects of dioxincontaining herbicides used during the war.But as a bumper sticker spotted on a Hanoi street pointed out, "Vietnam is a country, not a war," and today many of Vietnam's most pressing concerns are related to post-war growth.About half of Vietnam's current population of 80 million people is under 30 years old.This young generation, many of whom have a limited recollection of wartime, drives a sense of optimism about the future of the country.Foreign investment in this country for 2005 is estimated at US$5.4 billion, only a little less than investment in India, and Vietnam is expected to enter the World Trade Organization in mid-2006.
Hodgkin's Disease, Alcohol, and Vena Caval Obstruction
Authors: Bruce D. Cheson
Journal: JAMA (1978)

<h3>To the Editor.—</h3> Alcohol intolerance in patients with Hodgkin's disease is a symptom frequently mentioned yet infrequently sought in routine patient questioning. Such inquiries may be important in the management of the Hodgkin's patient. <h3>Report of a Case.—</h3> This was the first hospital admission for a previously healthy 20-year-old woman for evaluation of facial swelling of approximately two months' duration. This swelling gradually progressed to include her neck and chest, giving additional fullness to her breasts, and was associated with a dry, nonproductive cough, dyspnea, and orthopnea. Several weeks before admission the patient noted fever, night sweats, and generalized pruritus, but she did not experience jaundice, lymphadenopathy, or notable weight loss. During this period of her illness, she had not consumed any alcohol. Physical findings on admission included nonpitting facial and periorbital edema. There was no peripheral lymphadenopathy. The neck was greatly edematous with venous distension and prominent collaterals over
Elimination of Lipid Levels From Quality Measures
Authors: Nicholas W. Stine, Dave A. Chokshi
Journal: JAMA (2014)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Long-term treatment of atopic dermatitis with pimecrolimus cream 1% in infants does not interfere with the development of protective antibodies after vaccination
Authors: Kim A. Papp, Kristine Breuer, Michael Meurer, Jean-Paul Ortonne, Paul C. Potter, Yves de Prost, Miles J. Davidson, Nathalie Barbier, Hans-Peter Goertz, Carle Paul
Journal: Journal of the American Academy of Dermatology (2005)
Prostate-Derived ETS Factor Is a Mediator of Metastatic Potential through the Inhibition of Migration and Invasion in Breast Cancer
Authors: David P. Turner, Omar Moussa, Moira Sauane, Paul B. Fisher, Dennis K. Watson
Journal: Cancer Research (2007)

Abstract Cell migration and invasion are critical events during the progression to metastasis. Without motile function, cancer cells are unable to leave the primary tumor site, invade through the basement membrane, and form secondary tumors. Expression of the epithelial-specific ETS factor prostate-derived ETS factor (PDEF) is reduced in human invasive breast tissue and lost in invasive breast cancer cell lines. Gain-of-function studies that examine different aspects of cell migration show that constitutive or inducible PDEF reexpression inhibits migration and invasion in multiple breast cancer cell lines, and loss-of-function studies show a stimulation of migration in noninvasive breast cancer cells. Furthermore, the introduction of PDEF into invasive breast cancer cells led to a remodeling of the actin cytoskeleton and altered focal adhesion localization and adherence levels. Cells expressing PDEF no longer form the defined morphologic polarity required for efficient, directional migration. Collectively, these data indicate that PDEF down-regulation in invasive breast cancer may promote actin-mediated cell migration through the extracellular matrix. [Cancer Res 2007;67(4):1618–25]
Habitual physical activity and high-density lipoprotein cholesterol in men with primary hypercholesterolemia. The Lipid Research Clinics Coronary Primary Prevention Trial.
Authors: D J Gordon, J L Witztum, D Hunninghake, S Gates, C J Glueck
Journal: Circulation (1983)

The association of habitual physical activity with plasma high-density lipoprotein (HDL) cholesterol and total triglyceride (TG) was examined in 7106 asymptomatic 35-59-year-old white men with primary type II hyperlipoproteinemia who attended the second screening visit of the Lipid Research Clinics Coronary Primary Prevention Trial. Subjects were rated by usual level of physical activity at work and outside of work and the frequency of strenuous physical labor or exercise. By each of these three criteria, physical activity was monotonically related to HDL cholesterol and TG: the most physically active men had the highest HDL cholesterol and lowest TG levels. With respect to physical activity outside of work, for example, mean HDL cholesterol and TG were 46.4 and 152.1 mg/dl, respectively, in the most active group, and 41.4 and 186.7 mg/dl in the most sedentary group. Physical activity remained significantly predictive of HDL cholesterol and TG when other known correlates of these plasma constituents--age, Quetelet index, plasma total cholesterol, cigarette smoking, alcohol intake, and clinic--were controlled individually by two-way analyses of variance or jointly by analysis of covariance. The association of physical activity with very low density lipoprotein cholesterol was parallel to but weaker than its association with TG. Low-density lipoprotein and total cholesterol were not significantly related to physical activity.