tbuckley/cabot-search huggingface dataset:
The Pathology of the Pulmonary Vasculature
Authors: Lester S. King
Journal: JAMA (1964)

Pathology of the blood vessels of the lung may seem an extremely restricted subject for a quarto volume of almost 500 pages. But so interrelated is all knowledge that when we take one small area and study it intensively, we find surprising ramifications. Boundaries seem to fall away, and we confront not a narrow specialty but, rather, broad reaches of medical science. The volume begins by discussing the normal pulmonary vasculature at different ages. The pathological analyses contain a section on socalled general pathology which describes changes that affect one or another part of the vascular wall, or the wall as a whole. The greater part of the book, however, studies more or less specific disease states. Among the many topics covered may be mentioned pulmonary venous hypertension; pulmonary embolism; congenital anomalies of major pulmonary vessels; neoplasms and hamartomas of the vessels; vascular changes in various pulmonary conditions, such as
Drug-Induced Pericarditis
Authors: Robert C. Yates, Kenneth B. Olson
Journal: New England Journal of Medicine (1961)

THE purpose of this communication is to describe 3 cases of acute pericarditis as toxic manifestations of drug therapy.6-Amino-9-D-psicofuranosylpurine,§ an antibiotic originally described by Eble and his associates,1 is produced by a strain of actinomycete tentatively identified as Streptomyces hygroscopicus, var. decoyicus. It was found to be active2 , 3 against Staphy- lococcus aureus, Streptococcus haemolyticus and some strains of Escherichia coli in mice. It was almost inactive when tested in vitro. In addition to these properties the drug was found to have antitumor activity4 in several types of animal tumors, including Walker adenocarcinomas, Jensen sarcomas, Murphy—Sturm lymphosarcomas and Guerin tumors . . .
RELATIONSHIP BETWEEN HL-A ANTIGENS AND ß2-MICROGLOBULIN AS STUDIED BY IMMUNOFLUORESCENCE ON THE LYMPHOCYTE MEMBRANE
Authors: C. Neauport-Sautes, A. Bismuth, F. M. Kourilsky, Y. Manuel
Journal: The Journal of Experimental Medicine (1974)

The antibody-induced redistribution of ß2-microglobulin (ß2-µ) and HL-A antigens on the surface of living lymphocytes was studied by immunofluorescence. When all ß2-µ was redistributed on the lymphocyte membrane by specific rabbit antibodies and goat antirabbit Ig conjugates, the HL-A antigens were no more detectable with anti-HL-A conjugates outside the ß2-µ caps already formed. However, the redistribution of HL-A antigens fails to provoke the redistribution of all detectable ß2-µ molecules. These results suggest that HL-A antigens may be associated with ß2-µ at the cell surface, but that all ß2-µ molecules are not bound to HL-A antigens.
Mild Intraoperative Hypothermia during Surgery for Intracranial Aneurysm
Authors: Michael M. Todd, Bradley J. Hindman, William R. Clarke, James C. Torner
Journal: New England Journal of Medicine (2005)

Surgery for intracranial aneurysm often results in postoperative neurologic deficits. We conducted a randomized trial at 30 centers to determine whether intraoperative cooling during open craniotomy would improve the outcome among patients with acute aneurysmal subarachnoid hemorrhage.
Immune Readouts May Have Prognostic Value for the Course of Merkel Cell Carcinoma, a Virally Associated Disease
Authors: Christopher B. Buck, Douglas R. Lowy
Journal: Journal of Clinical Oncology (2011)

What are the research and clinical implications of this TEAM substudy?From a research perspective, this article suggests that quantitative assessment of ER status warrants additional investigation as a predictive biomarker.However, given the inherent technologic limitations of IHC, any conclusive data might be difficult to translate into a technically robust assay with high interlaboratory reproducibility.An RNA-based approach to this question might provide a more definitive assessment of such an effect. 12Nonetheless, the quantitative ER transcript determinations that were performed within the 21-gene score failed to specifically predict benefit from adjuvant anastrozole in ATAC participants. 13rom a clinical perspective, this article confirms that PgR is prognostic but not predictive, and provides no new insight with which to guide the practical decision to prescribe initial adjuvant AI therapy or tamoxifen to postmenopausal women with hormone receptorpositive breast cancer.Despite laudable efforts to identify and validate predictive biomarkers, the decision to prescribe an adjuvant AI is still made on the basis of an individual's risk of recurrence and contraindications to tamoxifen.
THE ALBUMOSURIA OF PHTHISIS.A CLINICAL STUDY.
Authors: J. F. M'CONNELL
Journal: JAMA (1905)

Some two years ago, while working up a series of urinalyses for the purpose of computing the prognostic value of Ehrlich's reaction in the tuberculous, my attention was directed to a large proportion of the specimens having a precipitate with the characteristics of an albumose. There was very little to be found in the literature concerning the significance of this adventitious content; to be more precise, many authorities denied that it portended anything. Hence, the investigation and conclusions here presented I believe to be original. Albumosuria may be defined as the presence in the urine of a primary product of the digestion of a proteid, differing from albumin in not being coagulable by heat. The albumoses appearing in the urine have a wide nomenclature, which is of little clinical interest. Suffice it to state that it has been conclusively shown that such products are in no wise to be considered
Deficits in Conditioned Fear Extinction in Obsessive-Compulsive Disorder and Neurobiological Changes in the Fear Circuit
Authors: Mohammed R. Milad, Sharon C. Furtak, Jennifer L. Greenberg, Aparna Keshaviah, Jooyeon J. Im, Martha J. Falkenstein, Michael Jenike, Scott L. Rauch, Sabine Wilhelm
Journal: JAMA Psychiatry (2013)

<h3>Importance</h3>Obsessive-compulsive disorder (OCD) may be characterized by impaired self-regulation and behavioral inhibition. Elevated fear and anxiety are common characteristics of this disorder. The neurobiology of fear regulation and consolidation of safety memories have not been examined in this patient population.<h3>Objective</h3>To examine the psychophysiological and neurobiological correlates of conditioned fear extinction in patients with OCD.<h3>Design</h3>Cross-sectional, case-control, functional magnetic resonance imaging study.<h3>Setting</h3>Academic medical center.<h3>Participants</h3>Twenty-one patients with OCD and 21 healthy participants.<h3>Main Outcomes and Measures</h3>Skin conductance responses and blood oxygenation level–dependent responses.<h3>Results</h3>The between-group difference noted in our psychophysiological measure (skin conductance responses) was during extinction recall: patients with OCD showed impaired extinction recall relative to control subjects. Regarding the functional magnetic resonance imaging data, patients with OCD showed significantly reduced activation in the ventromedial prefrontal cortex across training phases. Moreover, reduced activation in the patients with OCD was noted in the caudate and hippocampus during fear conditioning, as well as in the cerebellum, posterior cingulate cortex, and putamen during extinction recall. Contrary to our prediction, OCD symptom severity was positively correlated with the magnitude of extinction memory recall. Also contrary to our prediction, functional responses of the ventromedial prefrontal cortex were positively correlated with symptom severity, and functional responses of the dorsal anterior cingulate cortex were inversely correlated with symptom severity.<h3>Conclusions and Relevance</h3>As expected, our study showed that fear extinction and its neural substrates are impaired in patients with OCD. However, this study also yielded some surprising and unexpected results regarding the correlates between extinction capacity and its neural substrates and the severity of symptoms expressed in this disorder. Thus, our data report neural correlates of deficient fear extinction in patients with OCD. The negative correlations between fear extinction deficits and Yale-Brown Obsessive-Compulsive Scale symptoms in OCD suggest that there may be other factors, in addition to fear extinction deficiency, that contribute to the psychopathology of OCD.
Aquaporin 4 Expression and Tissue Susceptibility to Neuromyelitis Optica
Authors: Marcelo Matiello, Janet Schaefer-Klein, David Sun, Brian G. Weinshenker
Journal: JAMA Neurology (2013)

To understand the predilection for optic nerve and spinal cord pathologic changes in neuromyelitis optica (NMO). OBJECTIVE TO evaluate tissue-specific expression (RNA and protein) and supramolecular aggregation of aquaporin 4 (AQP4) in mouse, rat, and human tissues.Quantitative polymerase chain reaction, sodium dodecyl sulfate-polyacrylamide gel electrophoresis, and blue native polyacrylamide gel electrophoresis.Laboratory analysis of mouse, rat, and human tissue.Tissues from control individuals and 1 patient with NMO obtained at autopsy.Neuromyelitis optica in the patient.Tissue-specific messenger RNA and protein expression and supramolecular aggregation of AQP4.The AQP4 messenger RNA and proteins were much more highly expressed in the optic nerve and spinal cord relative to other regions of the brain and to non-central nervous system tissues in all species evaluated. Large supramolecular aggregates of AQP4 were overrepresented in the optic nerve and spinal cord relative to other central nervous system tissue. There was no difference in AQP4 expression between an individual with NMO and the control samples.Optic nerve tissue from an individual with NMO did not differ in AQP4 expression from control samples. The relatively high levels of expression and of supramolecular aggregation in the optic nerve and spinal cord may contribute to the predilection of these structures to NMO pathologic changes.
Prevention, early detection, or treatment?
Authors: Douglas Kamerow
Journal: BMJ (2005)

According to the American Cancer Society, the death rate from breast cancer for women has decreased about 2% annually since 1990. Why are fewer American women dying of breast cancer? Possibilities include changes in the biological behavior of breast cancer (unlikely), decreased incidence rate (preventing breast cancer from occurring), improved early detection (finding curable cancers), or better treatment (using new therapies that prolong life). But which one?

With increased mammographic screening, it is no surprise to find that the incidence …
Restoration of HCV-specific T cell functions by PD-1/PD-L1 blockade in HCV infection: Effect of viremia levels and antiviral treatment
Authors: Simona Urbani, Barbara Amadei, Daniela Tola, Giuseppe Pedrazzi, Luca Sacchelli, Maria Cristina Cavallo, Alessandra Orlandini, Gabriele Missale, Carlo Ferrari
Journal: Journal of Hepatology (2008)
Can Trichomonas vaginalis cause pneumonia in newborn babies?
Authors: I Hiemstra, F Van Bel, H M Berger
Journal: BMJ (1984)

Un nouveau-ne de 3690 g, apres 40 semaines d'une grossesse sans probleme, nait en etat d'asphyxie. Il est aussitot intube et ventile. Des expectorations epaisses sont aspirees de la trachee; toutes les recherches de bacteries donnent des resultats negatifs, mais on identifie, dans la trachee et dans l'estomac, Trichomonas vaginalis. Les radiographies thoraciques montrent des infiltrations pulmonaires; traitement par ampicilline et tobramycine i.v. L'amelioration est rapide, on renonce au traitement par metronidazole
Process of Becoming
Authors: Mary E. Bretscher
Journal: Annals of Internal Medicine (1997)

Ad Libitum1 December 1997Process of BecomingMary E. Bretscher, MDMary E. Bretscher, MDSpringfield Clinic; Springfield, IL 62794Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-127-11-199712010-00002 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail Works in progress,We are gradually transformedAs the wonders and energy and pains of othersSeep into the cracksWe never thought were thereAnd, like water in winter,Freezing and thawing,Imperceptibly but inevitablyLoosen our moorings,Carrying away a piece of usAs they leave in the spring.They leave in its placeA fine soft powderTo smooth our jagged edges,Or a gleaming spark of emeraldTo make us sing,Or the exquisitely perfect skeleton of a leaf,A gift of fragile beauty to grace our days.To become entwined in ... Author, Article, and Disclosure InformationAffiliations: Springfield Clinic; Springfield, IL 62794Corresponding Author: Mary E. Bretscher, MD, Springfield Clinic, 1025 South Seventh, Springfield, IL 62794. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 December 1997Volume 127, Issue 11Page: 965KeywordsSkeleton Issue Published: 1 December 1997 Copyright & PermissionsCopyright © 1997 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Extending the role of the clinical nurse
Authors: J K W Morrice
Journal: BMJ (1978)

young people, may take a small number of Distalgesic tablets, possibly as few as 10, with rapidly fatal results.These tablets are now widely available at home and may be consumed by persons to whom they were not originally prescribed.Frequently the overdose is taken impulsively, sometimes with alcohol and possibly without serious suicidal intent.If these people took a similar number of aspirin or paracetamol tablets they would not be harmed or would, at the worst, be responsive to treatment.The toxic effects of dextropropoxyphene should not be confused with those of paracetamol, with which it is usually combined.Furthermore, the relatively small safety margin of dextropropoxyphene, which is chemically related to morphine, should be more widely recognised.
Cimetidine and Visual Hallucinations
Authors: Shashi K. Agarwal
Journal: JAMA (1978)

<h3>To the Editor.—</h3> A few cases of mental confusion with cimetidine have been recognized. This has been seen after intake of a double or higher dose or at normal doses in older people. I wish to draw attention to visual hallucinations as a possible adverse effect of cimetidine therapy. <h3>Report of a Case.—</h3> A 72-year-old man was admitted with confusion, headache, and vomiting. He had sustained a head injury six weeks previously, for which he was given dexamethasone. He was found to be hypertensive and was treated with methyldopa and chlorothiazide. A CT scan and bilateral corotid angiograms disclosed bilateral frontoparietal chronic subdural hematomas. On the fourth hospital day a bilateral craniotomy was done, and liquified hematomas were evacuated. Postoperatively the patient was given 4 mg of dexamethasone every six hours, 30 cc of magnesium hydroxide (Mylanta) four times a day, and 100 mg of phenytoin sodium three times a
Short-term myocardial uptake of lidocaine and mexiletine in patients with ischemic heart disease.
Authors: J D Horowitz, M K Dynon, E Woodward, S T Sia, P S Macdonald, D J Morgan, A J Goble, W J Louis
Journal: Circulation (1986)

Determination of short-term myocardial drug uptake and subsequent redistribution was performed in 27 patients with ischemic heart disease for the antiarrhythmic agents lidocaine and mexiletine, using frequent simultaneous measurements of drug concentration in aortic and coronary sinus blood, combined with measurement of coronary sinus blood flow after intravenous bolus injection of the drug. Maximal myocardial drug content per unit resting coronary sinus blood flow (MDC:F) was significantly greater in patients in whom coronary sinus pacing at 100 beat/min was performed during the initial period of drug uptake. Maximal myocardial drug content occurred after 2.4 +/- 0.2 (SEM) for lidocaine and after 5.5 +/- 0.6 min for mexiletine (p less than .001), and pacing did not affect time to maximum myocardial drug content. In nonpaced, but not paced, patients maximal MDC:F was greater in the lidocaine group than that in the mexiletine group. The subsequent efflux of lidocaine from the myocardium was more rapid that that of mexiletine in both paced and nonpaced groups.
Coincident Duodenal and Gastric Ulcer
Authors: D. P. D. Wilkie
Journal: BMJ (1926)

THE surgical treatment of duiodenal and gastric ulcer is still the subject-of cointroversy, and opinion is sharply divided as to ther exact place whi-ch surgery should hold, and will ultimately -maintain, iA the treatmiient of this disorder.There is, -howviear', ani imposing accumulation of evidence of the curative actioni of a gastro-enterostomiiy in cases-of duodenal ulcer.Collective statistics show that colmplete relief from_ symp-toms follow-s in 85 per cent, of cases of duodenal ulcer followiing gastro-eniterostonmy.For gastric ulcer, on the other hand, this operation is much less
Treatment of treatment-resistant autoimmune blistering skin disorders with rituximab
Authors: A.Ø. Jensen, B.K. Møller, A. Vangkilde, B. Mark, E.R. Obitz, K. Kragballe, L. Iversen
Journal: British Journal of Dermatology (2009)

Journal Article Treatment of treatment‐resistant autoimmune blistering skin disorders with rituximab Get access A.Ø. Jensen, A.Ø. Jensen Department of Dermatology, Århus Sygehus, P. P. Ørumsgade, Århus University Hospital, 8000 Århus C, Denmark Search for other works by this author on: Oxford Academic Google Scholar B.K. Møller, B.K. Møller Department of Clinical Immunology, Skejby Sygehus, Århus University Hospital, Denmark Search for other works by this author on: Oxford Academic Google Scholar A. Vangkilde, A. Vangkilde Department of Dermatology, Århus Sygehus, P. P. Ørumsgade, Århus University Hospital, 8000 Århus C, Denmark Search for other works by this author on: Oxford Academic Google Scholar B. Mark, B. Mark Department of Dermatology, Århus Sygehus, P. P. Ørumsgade, Århus University Hospital, 8000 Århus C, Denmark Search for other works by this author on: Oxford Academic Google Scholar E.R. Obitz, E.R. Obitz Department of Dermatology, Århus Sygehus, P. P. Ørumsgade, Århus University Hospital, 8000 Århus C, Denmark Search for other works by this author on: Oxford Academic Google Scholar K. Kragballe, K. Kragballe Department of Dermatology, Århus Sygehus, P. P. Ørumsgade, Århus University Hospital, 8000 Århus C, Denmark Search for other works by this author on: Oxford Academic Google Scholar L. Iversen L. Iversen Department of Dermatology, Århus Sygehus, P. P. Ørumsgade, Århus University Hospital, 8000 Århus C, Denmark Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 160, Issue 6, 1 June 2009, Pages 1359–1361, https://doi.org/10.1111/j.1365-2133.2009.09132.x Published: 01 June 2009
Metabolism of adenosine 3′,5′-monophosphate by epithelial cells of the toad bladder
Authors: Paul F. Gulyassy
Journal: Journal of Clinical Investigation (1968)

When whole urinary bladders of the toad were incubated with adenosine 3',5'-monophosphate-(3)H (cyclic AMP-(3)H) > 95% of the radioactivity could be extracted from the tissue with trichloroacetic acid (TCA). The TCA-soluble radioactivity was separable by cation-exchange (Dowex-50) chromatography into residual cyclic AMP-(3)H, 5'-AMP-(3)H, adenosine diphosphate (ADP)-(3)H and inosine-(3)H. Thus, neither substantial tight binding of cyclic AMP to TCA-precipitable cell constituents nor any novel metabolite of cyclic AMP were found. On exposure of cyclic AMP-(3)H to a crude homogenate of the epithelial cells scraped from the mucosal face of the bladder, the principal metabolite was inosine-(3)H, whereas 5'-AMP-(3)H was either absent or present in undetectible amounts. However, when the homogenate included added 5'-AMP (2 x 10(-2) mole/liter), substantial quantities of 5'-AMP-(3)H were recovered. Metabolism of cyclic AMP-(3)H by homogenates of the epithelial cell scrapings from the bladder was strongly stimulated by alkalinization over the range in pH of 6-9. Theophylline inhibited metabolism of cyclic AMP only to a limit of 50%, the inhibition being limited to the OH(-)-stimulated component. These results suggest the possibility that a second pathway for metabolism of cyclic AMP may exist. If such is the case, its relationship, if any, to the ultimate biological effects of cyclic AMP within cells will be studied.
CURRENT AHA/ACC AORTIC STENOSIS DEFINITIONS DO NOT PROVIDE CONSISTENT PROGNOSTIC IMPACT AFTER AORTIC VALVE REPLACEMENT SURGERY.
Authors: Sophie Pierard, Christophe de Meester, Stéphanie Seldrum, David Vancraeynest, Agnès Pasquet, Bernhard L. Gerber, Jean-Louis Vanoverschelde
Journal: Journal of the American College of Cardiology (2011)
[57] 3 YEARS OF ADEFOVIR AND LAMIVUDINE COMBINATION THERAPY MINIMIZES THE RISK OF GENOTYPIC RESISTANCE TO ADV IN LAM RESISTANT PATIENTS
Authors: P. Lampertico, M. Vigano, E. Manenti, M. Tavarone, G. Lunghi, E. Del Ninno, M. Colombo
Journal: Journal of Hepatology (2007)
On Human Nature
Authors: Marjorie C. Meehan
Journal: JAMA (1978)

Much controversy followed the 1975 publication of Wilson's<i>Sociobiology</i>. Most reviewers ignored the fascinating description of the social habits of various life forms and their evolutionary development. Instead, they argued about the final chapter in which Wilson discussed human social behavior and asserted that it is, in part, determined by genetic evolution. Now, Wilson has published a new book,<i>On Human Nature</i>, in which he expands and clarifies the ideas of that last chapter. He asserts that humankind has evolved by natural selection, that the mind can be explained as the summed activity of chemical and electric reactions, and that, therefore, human nature can be an object of empirical research. However, he insists that biology can serve liberal education and thereby enrich rather than diminish our self-conception. He notes that this biologic interpretation of human nature leads to two difficulties, which he calls spiritual dilemmas. The first is that our
Viral Infection Augments Nod1/2 Signaling to Potentiate Lethality Associated with Secondary Bacterial Infections
Authors: Yun-Gi Kim, Jong-Hwan Park, Thornik Reimer, Darren P. Baker, Taro Kawai, Himanshu Kumar, Shizuo Akira, Christiane Wobus, Gabriel Núñez
Journal: Cell Host & Microbe (2011)
Two Blocks South, Take a Right
Authors: ERIC A. RAVITZ
Journal: Annals of Internal Medicine (1986)

Ad Libitum1 November 1986Two Blocks South, Take a RightERIC A. RAVITZ, D.O.ERIC A. RAVITZ, D.O.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-105-5-809_1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail Excerpt"So Jim, you've really decided to go ahead and try to set up in solo private practice in this day and age. ""Yeah, I've always fancied myself the people's doctor, practicing alone, my own boss, freedom to do what I choose, the American Dream. My Army experience sure has soured me on large corporate medicine. I want to give good individualized not industrialized care.""I can understand your feelings but what an awesome undertaking. How are you going to get started?""First, I think the key is location. That's what I want to bounce off you today.""Excellent! How... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Des Moines, Iowa PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 November 1986Volume 105, Issue 5Page: 809-809KeywordsEmotions ePublished: 1 December 2008 Issue Published: 1 November 1986 PDF downloadLoading ...