tbuckley/cabot-search huggingface dataset:
OBSERVATIONS ON MASS CHEMO-PROPHYLAXIS WITH SULFADIAZINE
Authors: Bennett W. Billow, M. S. Albin
Journal: Annals of Internal Medicine (1946)

Article1 May 1946OBSERVATIONS ON MASS CHEMO-PROPHYLAXIS WITH SULFADIAZINEBENNETT W. BILLOW, M.D., M. S. ALBINBENNETT W. BILLOW, M.D.Search for more papers by this author, M. S. ALBINSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-24-5-863 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptIt is the purpose of this communication to report an analysis of mass sulfadiazine prophylaxis. About 20,000 soldiers were given the prophylactic medication for a period of five weeks. Perusal of the literature reveals that the prophylactic use of sulfonamides has been investigated and studied by both military and civilian authorities. Thomas and France1administered prophylactic sulfanilamide for four years in doses of 1.0 to 1.2 grams a day to a group of rheumatic adolescents and young adults and compared the results with those observed in an untreated control group of similar subjects. Their results showed not a single major...Bibliography1. THOMASFRANCE CBR: The prophylactic use of sulfanilamide in patients susceptible to rheumatic fever, Jr. Am. Med. Assoc., 1941, cxvi, 577. Google Scholar2. COBURNMOORE AFLV: Prophylactic use of sulfanilamide in streptococcal respiratory infections with especial reference to rheumatic fever, Jr. Clin. Invest., 1939, xviii, 147. CrossrefGoogle Scholar3. FELDT RH: Sulfanilamide as a prophylactic measure in recurrent rheumatic infection: a controlled study involving one hundred and thirty-one "patient seasons," Am. Jr. Med. Sci., 1944, ccvii, 483. CrossrefGoogle Scholar4. KUTNERREYERSBACH AGG: Prevention of streptococcal upper respiratory infections and rheumatic recurrences in rheumatic children by prophylactic use of sulfanilamide, Jr. Clin. Invest., 1943 xxii, 77. CrossrefGoogle Scholar5. THOMAS CB: Prevention of recurrences in rheumatic subjects, Jr. Am. Med. Assoc., 1944, cxxvi, 491. Google Scholar6. Sulfadiazine in the prevention of respiratory disease, U. S. Army Med. Dept., 1944, lxxxiii, 5-7. Google Scholar7. TODDSANFORD JCAH: Clinical diagnosis by laboratory methods, 10th Edition, 1944, W. B. Saunders Company, Philadelphia, pp. 267-278. Google Scholar8. RATNER B: Allergy anaphylaxis and immunotherapy, 1943, Williams and Wilkins Company, Baltimore, pp. 140-141; 579-595. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: *Received for publication September 14, 1945. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited bySTEVENS-JOHNSON SYNDROME REPORT OF A CASEAntimicrobial Treatment for Viral and Related Infections 1 May 1946Volume 24, Issue 5Page: 863-877KeywordsAdolescentsArmed forcesProphylaxisSulfonamideYoung adults ePublished: 1 December 2008 Issue Published: 1 May 1946 PDF downloadLoading ...
EPIDEMIC INFLUENZA: STUDIES IN CLINICAL EPIDEMIOLOGY
Authors: Thomas Francis
Journal: Annals of Internal Medicine (1939)

Article1 December 1939EPIDEMIC INFLUENZA: STUDIES IN CLINICAL EPIDEMIOLOGYTHOMAS FRANCIS JR., M.D.THOMAS FRANCIS JR., M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-13-6-915 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptAlthough based on well recognized modes of action, clinical epidemiology as a scientific concept has but recently evolved.1, 2 It has its origins, on the one hand, in the type of epidemiology which interests itself not only in the manner in which an epidemic arises but also in the varying characteristics of the epidemic disease in the affected individuals. On the other hand, its roots extend, as Paul2 has pointed out, into the heart of family practice where the physician dealing primarily with the sick individual attempts to study the patient in relation to his familial or communal setting.The...Bibliography1. FRANCIS T: Immunology of epidemic influenza (De Lamar lecture), Am. Jr. Hyg., 1938, xxviii, 63. Google Scholar2. PAUL JR: President's address; clinical epidemiology, Jr. Clin. Invest., 1938, xvii, 539. CrossrefGoogle Scholar3. FRANCIS TFor detailed reports and bibliography see: (a) : Epidemiological studies in influenza, Am. Jr. Pub. Health, 1937, xxvii, 211. (b) FRANCIS, T., JR., MAGILL, T. P., RICKARD, E. R., and BECK, M. D.: Etiological and serological studies in epidemic influenza, Am. Jr. Pub. Health, 1937, xxvii, 1141. (c) STUART-HARRIS, C. H., ANDREWES, C. H., and SMITH, W. S., with D. K. M. CHALMERS, E. G. H. COWEN, and D. L. HUGHES: A study of epidemic influenza: with special reference to the 1936-7 epidemic, Med. Res. Council, Spec. Rep. Series, No. 228, 1938, H. M. Stationery Off., London. CrossrefGoogle Scholar4. FRANCISMAGILL TTP: Unidentified virus producing acute meningitis and pneumonitis in experimental animals, Jr. Exper. Med., 1938, lxviii, 147. CrossrefGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: New York, N. Y.*Read at the New Orleans meeting of the American College of Physicians March 28, 1939. Nextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byBibliographySOCIAL MEDICINETHE DOCTOR, THE MOTHER, AND THE SICK CHILDViruskrankheiten des RespirationstraktesNoninfluenzal Viral Infections of the Respiratory TractTHE NOMENCLATURE OF INFLUENZA 1 December 1939Volume 13, Issue 6Page: 915-922KeywordsClinical epidemiologyHeartLongitudinal studies ePublished: 1 December 2008 Issue Published: 1 December 1939 Copyright & PermissionsCopyright, 1939, by The American College of PhysiciansPDF downloadLoading ...
Abstract 2876: Genetic polymorphism in <i>the mir-196a</i> as a prognostic biomarker for early breast cancer
Authors: Soo Jung Lee, Yee Soo Chae, Byung Woog Kang, Jong Gwang Kim, Ji-Young Park, Jin Hyang Jung, Ho Yong Park
Journal: Cancer Research (2014)

Abstract Background: MicroRNAs (miRNA) may play important roles in tumorigenesis by regulating the expressions of proto-oncogenes or tumor suppressor genes. Single nucleotide polymorphisms (SNP) in miRNA-coding genes and miRNA binding site genes might affect miRNA-mediated gene regulation, thereby contributing to the susceptibility or prognosis of cancer. Accordingly, the present study analyzed SNPs located in miRNA and miRNA-binding sites of various genes and their impact on the prognosis for patients with early breast cancer (EBC) by altering miRNA binding efficiency. Methods: Four hundred and fifty-two consecutive patients with curative resection were enrolled in the present study. Three SNPs (rs11614913, rs3746444 and rs1044129 of miR-196a, miR-499a and miR-367, respectively) were selected in Silico analysis for the current study based on several miRNA database and HapMap database. The SNP genotyping was performed using the Sequenom MassARRAY. Results: The median age of all patients was 48 years, and 298 (66.7%) had ER/PR-positive EBC, 64 (14.3%) had HER2-overexpressed EBC, and 79 (17.7%) had triple-negative EBC. The pathologic stages after the surgical resection were as follows: stage I (n=174, 38.5%), stage IIA (n=168, 37.2%), stage IIB (n=54, 11.9%), and stage IIIA (n=56, 12.4%). During the median follow-up of 6.9 (range 0.37 -19.93) years, 67 (14.8%) relapses and 47 (10.4%) deaths occurred. Among the 3 polymorphisms miR-196a rs11614913T&amp;gt;C was significantly associated with disease-free survival (DFS) and distant DFS (DDFS) when adjusted for age, histologic grade, receptor status, and pathologic stage. In particular, the prognostic impact of rs11614913 was limited to the HR- expressed subtype, where the patients bearing the CC genotype showed worse survival in terms of DFS and DDFS compared with those with the TT or TC genotype as a recessive model (HR= 2.571 and P-value=0.031, HR= 4.263 and P-value=0.001, respectively). Meanwhile, there were no statistical differences in patient and tumor characteristics among each genotype of rs11614913. Conclusions: The current study provides evidence that the miR-196a rs11614913T&amp;gt;C polymorphism is a possible prognostic biomarker for patients with HR-expressed early breast cancer. Citation Format: Soo Jung Lee, Yee Soo Chae, Byung Woog Kang, Jong Gwang Kim, Ji-Young Park, Jin Hyang Jung, Ho Yong Park. Genetic polymorphism in the mir-196a as a prognostic biomarker for early breast cancer. [abstract]. In: Proceedings of the 105th Annual Meeting of the American Association for Cancer Research; 2014 Apr 5-9; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2014;74(19 Suppl):Abstract nr 2876. doi:10.1158/1538-7445.AM2014-2876
Abstract 13330: Steam Pop Prediction and Detection During Radiofrequency Ablation
Authors: Douglas S Holmes, Jeffrey M Fish, Israel A Byrd, Lynn E Clark, Michael Corner, Christopher Geurkink, Robert D Aiken, Larry A Chinitz
Journal: Circulation (2011)

Introduction:  Steam pops can occur during RF ablation when tissue temperatures exceed 100 C. While tactile and audible cues are used for their detection, background lab noise and catheter movement may confound identification. The EnSite™ Contact System measures, as an Electrical Coupling Index (ECI), both resistive and reactive impedance between the ablation catheter and tissue. ECI is displayed as a continuous waveform during ablation. The objective of this study was to determine if ECI could aid in steam pop detection and prediction.   Methods:  Power control RF ablation lesions (30 - 50 W, 60 s, n = 160) were created in the RA, LA, and RV of 13 swine using a 4 mm open irrigated RF ablation catheter. A Millar catheter placed in the RA or aorta and a digital stethoscope placed on the chest wall served as gold standards for steam pop detection: simultaneous spikes on traces from both devices defined a steam pop. Conventional steam pop detection was compared to the gold standard in 6 swine. The prediction capability of a previously derived steam pop prediction algorithm using ECI components plus conventional parameters was also tested. Data collected included the time of steam pop, power, duration, temperature, and impedance from the RF generator and ECI.   Results:  Steam pops occurred in 25 lesions causing cardiac tamponade in 2 swine. Mean time to pop was 28 ± 16 s. Tactile and audible cues identified only 67% of steam pops. For these, even when pops were barely audible, ECI deviations were always clear and confirmatory. All the non-perceived pops occurred in the atria. The steam pop prediction algorithm accurately predicted 92% of all steam pops at least 3 s before they occurred, including all of the non-perceived pops. The negative predictive value of the steam pop prediction algorithm was 98%.   Conclusions:  The incidence of steam pops in the atria is higher than typically appreciated using conventional means. ECI may be a useful tool for both steam pop detection and prediction.
Loss-of-function mutations in the EGF-CFC gene CFC1 are associated with human left-right laterality defects
Authors: Richard N. Bamford, Erich Roessler, Rebecca D. Burdine, Umay Şaplakoğlu, June dela Cruz, Miranda Splitt, Jeffrey Towbin, Peter Bowers, Bruno Marino, Alexander F. Schier, Michael M. Shen, Maximilian Muenke, Brett Casey
Journal: Nature Genetics (2000)
BCR-ABL Transcripts in Bone Marrow Aspirates of Philadelphia-Negative Essential Thrombocythemia Patients: Clinical Presentation
Authors: Dorit Blickstein, Adina Aviram, Jacob Luboshitz, Miron Prokocimer, Pinhas Stark, Osnat Bairey, Jaqueline Sulkes, Mati Shaklai
Journal: Blood (1997)
Abstract 18492: Cardiac-specific Ablation of Synapse-Associated Protein SAP97 in Mice Decreases Potassium Currents but Not Sodium Current
Authors: Ludovic Gillet, Jean-Sébastien Rougier, Stephan Sonntag, Diana Shy, Nathalie Mougenot, Maria Essers, Doron Shmerling, Stéphane Hatem, Elise Balse, Hugues Abriel
Journal: Circulation (2014)

Introduction:  Membrane-associated guanylate kinase (MAGUK) proteins are determinants of ion channel organization at the plasma membrane of various cell types. In the heart, the MAGUK protein SAP97 interacts with several ion channels via their PDZ-domain-binding motif and thus regulates their function and localization. SAP97 is considered as a susceptibility gene for inherited arrhythmias. In order to investigate the role of SAP97 in the mouse heart, we generated a genetically-modified mouse line where SAP97 was constitutively suppressed exclusively in cardiomyocytes.   Methods:  SAP97fl/fl mice were generated by inserting LoxP sequences flanking exons 1 to 3 of the SAP97 gene. SAP97fl/fl mice were bred with αMHC-Cre mice to generate αMHC-Cre/SAP97fl/fl mice with a cardiomyocyte-specific deletion of SAP97. Whole hearts and isolated cardiomyocytes from 10-13 week old mice were used. SAP97 protein and mRNA expression levels were measured by Western-blot and quantitative RT-PCR. The patch-clamp technique was used to record ion currents and action potentials (AP). Echocardiography and surface ECGs were performed on anesthetized mice.   Results:  Western blots showed a 71±4% decrease in SAP97 protein levels of αMHC-Cre/SAP97fl/fl hearts compared to SAP97fl/fl control hearts, while SAP97 mRNA transcript levels were decreased by 80±2% (n=4, p   Conclusions:  These data suggest that constitutive ablation of SAP97 in the mouse heart mainly alters potassium channel function and/or localization. Additional experiments are needed to elucidate whether ion channel expression at the plasma membrane and/or unitary conductance is modified.
Endoscopic Histoacryl Obliteration vs. Propranolol in the Prevention of Esophagogastric Variceal Rebleeding: A Randomized Trial
Authors: S. Evrard, J.-M. Dumonceau, M. Delhaye, P. Golstein, J. Devière, O. Le Moine
Journal: Endoscopy (2003)

The obliteration of esophageal and/or gastric varices using Histoacryl is highly effective in controlling active bleeding. However, it is not known whether repeated injections are useful for the long-term eradication of esophagogastric varices. The aim of the study was to compare endoscopic Histoacryl obliteration with propranolol in the secondary prevention of esophagogastric variceal bleeding.Between August 1995 and February 1999, 41 patients with a first bleeding from esophageal (n = 31) or gastric (n = 10) varices were included in the study. After primary hemostasis with obliteration using Histoacryl, patients were randomly allocated either to undergo complete Histoacryl obliteration of the remaining varices (group A, n = 21) or to long-term propranolol administration (group B, n = 20), for the prevention of rebleeding.The two groups were well matched for age, sex, etiology of cirrhosis, Child-Pugh score, renal function, and infection at the time of admission. The median follow-up was 31.9 months (4.8 - 74.7) for group A and 23.2 months (3.0 - 70.0) for group B. Initial hemostasis was achieved in 40/41 patients (97 %). No significant difference was observed between groups A and B with regard to the incidence of early rebleeding (during the first 6 weeks; 5/21 and 3/20), bleeding-related deaths by 6 weeks (3/21 and 6/20), long-term rebleeding (11/21 and 5/20), or overall number of deaths (9/21 and 9/20). The incidence of complications was higher in group A (10/21) than group B (2/20) (P < 0.03).Repeated injections of Histoacryl with the aim of eradicating esophagogastric varices are associated with more complications compared with beta-blocker administration, with similar results in terms of rebleeding rate and survival in the long term.
Israeli health fund sues tobacco company
Authors: Judy Siegel-Itzkovich
Journal: BMJ (1998)

Israel's second largest public medical insurer has filed a suit demanding $486m (£300m) from Dubek, the country's only cigarette manufacturer, to cover its costs in treating members' smoking related illnesses.

Lawyers for the Maccabi health fund, which insures nearly a quarter of Israel's population, filed the suit in the Tel Aviv district court, saying it had spent $71m a year since …
In vivo genome editing of the albumin locus as a platform for protein replacement therapy
Authors: Rajiv Sharma, Xavier M. Anguela, Yannick Doyon, Thomas Wechsler, Russell C. DeKelver, Scott Sproul, David E. Paschon, Jeffrey C. Miller, Robert J. Davidson, David Shivak, Shangzhen Zhou, Julianne Rieders, Philip D. Gregory, Michael C. Holmes, Edward J. Rebar, Katherine A. High
Journal: Blood (2015)
Kronik ürtikerde kontakt duyarlanmanın rolü
Authors: Laura Guerra, Anthi Rogkakou, Piera Massacane, Cinzia Gamalero, Enrico Compalati, Cristian Zanella, Antonio Scordamaglia, Walter G. Canonica, veGiovanni Passalacqua
Journal: Journal of the American Academy of Dermatology (2007)
Abstract 11022: Time-Dependent Changes of Local Coagulative Response up to Five Years After Sirolimus-Eluting Stent Implantation
Authors: Koji Yamaguchi, Tetsuzo Wakatsuki, Toshiyuki Niki, Yoshio Taketani, Sachiko Bando, Sahika Hisaoka, Kenya Kusunose, Yuka Ueta, Hidekazu Takeuchi, Takashi Iwase, Noriko Tomita, Hirotsugu Yamada, Takeshi Soeki, Masashi Akaike, Masataka Sata
Journal: Circulation (2010)
A search for type 1 diabetes susceptibility genes in families from the United Kingdom
Authors: CharlesA. Mein, Laura Esposito, Michael G. Dunn, Gillian C. L. Johnson, Andrew E. Timms, Juliet V. Goy, Annabel N. Smith, Liam Sebag-Montefiore, Marilyn E. Merriman, Amanda J. Wilson, Lynn E. Pritchard, Francesco Cucca, Anthony H. Barnett, Stephen C. Bain, John A. Todd
Journal: Nature Genetics (1998)
Ranibizumab and Bevacizumab for Neovascular Age-Related Macular Degeneration
Authors: Daniel F Martin, Maureen G Maguire, Gui-shuang Ying, Juan E Grunwald, Stuart L Fine, Glenn J Jaffe
Journal: New England Journal of Medicine (2011)

Clinical trials have established the efficacy of ranibizumab for the treatment of neovascular age-related macular degeneration (AMD). In addition, bevacizumab is used off-label to treat AMD, despite the absence of similar supporting data.In a multicenter, single-blind, noninferiority trial, we randomly assigned 1208 patients with neovascular AMD to receive intravitreal injections of ranibizumab or bevacizumab on either a monthly schedule or as needed with monthly evaluation. The primary outcome was the mean change in visual acuity at 1 year, with a noninferiority limit of 5 letters on the eye chart.Bevacizumab administered monthly was equivalent to ranibizumab administered monthly, with 8.0 and 8.5 letters gained, respectively. Bevacizumab administered as needed was equivalent to ranibizumab as needed, with 5.9 and 6.8 letters gained, respectively. Ranibizumab as needed was equivalent to monthly ranibizumab, although the comparison between bevacizumab as needed and monthly bevacizumab was inconclusive. The mean decrease in central retinal thickness was greater in the ranibizumab-monthly group (196 μm) than in the other groups (152 to 168 μm, P=0.03 by analysis of variance). Rates of death, myocardial infarction, and stroke were similar for patients receiving either bevacizumab or ranibizumab (P>0.20). The proportion of patients with serious systemic adverse events (primarily hospitalizations) was higher with bevacizumab than with ranibizumab (24.1% vs. 19.0%; risk ratio, 1.29; 95% confidence interval, 1.01 to 1.66), with excess events broadly distributed in disease categories not identified in previous studies as areas of concern.At 1 year, bevacizumab and ranibizumab had equivalent effects on visual acuity when administered according to the same schedule. Ranibizumab given as needed with monthly evaluation had effects on vision that were equivalent to those of ranibizumab administered monthly. Differences in rates of serious adverse events require further study. (Funded by the National Eye Institute; ClinicalTrials.gov number, NCT00593450.).
Abstract P286: Disparities in Meeting Physical Activity Guidelines in Asian Americans in Los Angeles and in New York City
Authors: Stella S Yi
Journal: Circulation (2015)

Introduction:  Physical activity (PA) levels in Asian American (AA) adults appear to be lower than other racial/ethnic groups, but have only been described in a few studies. New York City and Los Angeles County together consist of 10% of the country’s AA population. Due to physical and geographic differences, LA and NYC provide differing opportunities for PA. These differences provide a natural experimental design to elucidate whether the observed disparity in AAs for meeting PA guidelines is similar and thus potentially driven by cultural norms that supersede structural differences, or dissimilar across the two areas.   Hypothesis:  To test the hypothesis that AAs are less likely to meet PA guidelines than US-born whites regardless of location of residence.   Methods:  The LA County Health Survey (2011) and the NYC Community Health Survey (2010, 2012) are cross-sectional, telephone surveys (LA: n=8,036; NYC: n=17,462). The 2008 PA Guidelines of America for aerobic activity recommend that adults should perform 2.5 hours/week of moderate-intensity, 75 minutes/week of vigorous-intensity PA, or an equivalent combination. The primary outcome of meeting PA guidelines was calculated using self-reported moderate or vigorous minutes/week. Descriptive statistics were used to estimate the prevalence of AAs in total and by subgroup (i.e., Chinese, Asian Indian, etc.) meeting PAGA recommendations for exercise compared to US-born whites. Multivariable regression models adjusting for age, sex, poverty level, and education were run. All data were weighted to be representative of their respective geographies, and analyzed in SUDAAN 10.0.   Results:  The prevalence of meeting PA guidelines was similar between LA and NYC overall (LA: 61.8; NYC: 57.9). In both areas, AAs were less likely than U.S.-born whites to meet guidelines, with the observed disparity larger in NYC than in LA (LA Asians: 55.8 [51.2-60.2]; LA US-born whites: 65.7 [63.4-67.9]; NYC Asians: 42.7, [39.2-46.3]; NYC US-born whites: 62.3 [60.3-64.3]). The Asian/US-born white disparity persisted after adjustment for covariates (LA: OR 0.61 [0.49, 0.76]; NYC: OR 0.56 [0.46, 0.68]). By Asian subgroup, the lowest prevalence of meeting guidelines was observed in Chinese Americans (LA: 52.2; NYC: 29.8).   Conclusions:  AAs were less likely to meet PA guidelines compared to US-born whites in both LA and NYC, areas that provide different structural opportunities for PA. Given the consistency of results across these locations, cultural and ethnic norms are implicated as a potential explanation for these differences. The low prevalence of meeting PA guidelines in Chinese Americans may be driving these effects, given they comprise the largest proportion of AAs in both places (LA: 36.5; NYC: 67.1). In conclusion, future work should introduce opportunities for PA in AA communities, with a targeted focus on Chinese Americans using culturally tailored strategies.
Polymeric-based perivascular delivery of a nitric oxide donor inhibits intimal thickening after balloon denudation arterial injury: role of nuclear factor-kappaB11This work was supported by a grant from the Henry W. Wheeler Research Fund.
Authors: Sanjay Kaul, Bojan Cercek, Jan Rengstrom, Xiao-Ping Xu, Mia D Molloy, Paul Dimayuga, Akik K Parikh, Michael C Fishbein, Jan Nilsson, Tripathi B Rajavashisth, Prediman K Shah
Journal: Journal of the American College of Cardiology (2000)