tbuckley/cabot-search huggingface dataset:
Alterations in endocardial activation of the canine papillary muscle early and late after myocardial infarction.
Authors: M G Kienzle, R C Tan, B M Ramza, M L Young, R W Joyner
Journal: Circulation (1987)

Permanent coronary occlusion produces time-dependent changes in surviving subendocardial cellular properties. We compared the functional alterations in Purkinje (P) and ventricular muscle (VM) activation early (24 hr) and late (4 weeks or greater) after permanent coronary occlusion in an in vitro preparation of canine papillary muscle. High-density extracellular (1 to 2 mm resolution) and selected intracellular recordings were made in five animals early and seven animals late during stimulation of a free-running P strand. Activation patterns of P and VM layers from ischemic and unaffected papillary muscles were compared in the same animal. Average P layer conduction velocity was determined in normal and ischemic regions with the use of a linear array of recording and stimulating electrodes. Purkinje activation was altered little in the early phase of infarction, while healing was associated with a generalized 25% reduction in P layer conduction velocity and localized block and fragmentation of P waveforms. Intracellular recordings at sites of nonsynchronous P activation revealed electrotonic interaction between cell groups. At 24 hr, small groups of VM were present but with abnormal activation patterns in regions of necrosis with fragmented and delayed extracellular waveforms produced by partially uncoupled groups of cells. Local delay and block could be modulated by rate and site of stimulation. After healing, VM activation abruptly stopped at the visual infarct border, marked by a characteristic "end potential." These studies demonstrate important differences in the functional attributes of the P and VM layers studied early and late after coronary occlusion. Alterations in cell-to-cell relationships are likely very important in determining abnormalities of activation in both settings.
590 B. pseudocatenulatum CECT 7769 ADMINISTRATION DECREASES INFLAMMATION AND BACTERIAL TRANSLOCATION IN THE LIVER OF MICE DURING CCl4-INDUCED CIRRHOSIS
Authors: A. Moratalla, I. Gómez-Hurtado, P. Zapater, G. Peiró, A'. Moya, J.M. González-Navajas, J. Such, Y. Sanz, R. Francés
Journal: Journal of Hepatology (2013)
Unexpected Detection of Melanoma Brain Metastasis by PET With Iodine-124 βCIT
Authors: Giuseppe Lucio Cascini, Andrea Ciarmiello, Angelo Labate, Stefania Tamburrini, Aldo Quattrone
Journal: Clinical Nuclear Medicine (2009)

To study the potential impact of iodine-124-beta-carbomethoxy-3beta(4-iodophenyl)tropane (I-124 betaCIT) in Parkinson disease, a I-124 betaCIT-PET scan was performed in 30-year-old man with suspected early Parkinson disease. The scan showed normal striatum uptake together with a focal spot in the left parietal cortex. The subsequent magnetic resonance imaging of the brain revealed a corresponding nodular lesion, presumably representing a metastasis. After clinical and diagnostic evaluation, a malignant metastatic melanoma was discovered. betaCIT is a cocaine derivative with a high affinity for dopamine and serotonin transporters mainly used to image the density of the dopamine reuptake transporter. In fact the role of I-123 betaCIT is typically represented by Parkinsonian syndromes of uncertain classification. The iodine-124 betaCIT uptake is a marker of dopamine transporters density, and the presence of focal uptake corresponding to a lesion on magnetic resonance images suggests a specific binding in this case of melanoma brain metastasis.
Effects of Putrescine on D–Galactosamine-Induced Acute Liver Failure in Rats
Authors: Shuhei Nishiguchi, Tetsuo Kuroki, Tadashi Takeda, Shinya Nakajima, Susumu Shiomi, Shuichi Seki, Isao Matsui-Yuasa, Shuzo Otani, Kenzo Kobayashi
Journal: Hepatology (1990)

We studied the effect of putrescine on acute liver failure caused in rats by two injections of 1 gm/kg D-galactosamine. The hepatic polyamine level rose only slightly in the D-galactosamine-injected rats treated with glucagon and insulin, and [3H]thymidine incorporation into DNA increased little; these hormones did not improve the survival rate. When D-galactosamine-injected rats were given putrescine, the putrescine concentration in the liver increased and the survival rate of the rats was significantly higher than that of control rats given only D-galactosamine. Putrescine administration tended to lower the serum level of alanine aminotransferase in rats injected with D-galactosamine, so the polyamine might have a protective effect on hepatocytes. Putrescine significantly increased [3H]thymidine incorporation in the liver; thus it accelerated liver regeneration. Difluoromethylornithine decreased the level of putrescine in the liver, decreasing both [3H]thymidine uptake and the survival rate. In the rats treated with D-galactosamine, in which liver damage was so severe that treatment with glucagon and insulin was ineffective, the intraperitoneal administration of putrescine increased the survival rate in acute liver failure. This probably resulted mainly from activation of liver regeneration and possibly from a protective effect of putrescine on the liver.
-Blockers and Plasma Renin Activity in Hypertension
Authors: G. S. Stokes, M. A. Weber, I. R. Thornell
Journal: BMJ (1974)

Long-term treatment with propranolol was shown to produce a sustained suppression of the renin-aldosterone system in hypertensive patients, despite concurrent diuretic treatment. However, the antihypertensive effect of this treatment correlated poorly with its effects on plasma renin activity and urinary aldosterone excretion. When prindolol, another β-adrenergic blocking drug, was substituted for propranolol, blood pressure control was retained, but there was a prompt rise in plasma renin activity, which was not attributable to changes in electrolyte balance. These observations suggest that the antihypertensive action of propranolol and other β-blockers does not result from their effects on plasma renin activity.
Induced Vasodilation as Treatment for Raynaud's Disease
Authors: Jared B. Jobe, James B. Sampson, Donald E. Roberts, William P. Beetham
Journal: Annals of Internal Medicine (1982)

We examined the efficacy of induced vasodilation as a treatment of idiopathic Raynaud's disease. Eight persons with Raynaud's disease and seven normal persons each received 27 simultaneous pairings of hand immersion in warm water (43 degrees C) for 10 minutes with exposure of the whole body to cold (0 degrees C). A second group of seven normal persons and nine persons with Raynaud's disease received no treatments. All subjects had cold test exposures (0 degrees C) at the start and end of the study. Subjects with Raynaud's disease who received treatments showed significant increases in digital temperatures (2.2 degrees C) during the cold test compared with the values of untreated subjects with Raynaud's disease (p less than 0.05); normal subjects who had received treatments showed no difference from those who had not. Digital temperatures of subjects with Raynaud's disease after treatment increased to levels approaching those of normal subjects, although they showed lower digital temperatures during initial exposure to cold (p less than 0.01). This therapy offers a practical alternative to traditional treatments.
Partial and Transient Reduction of Glycolysis by PFKFB3 Blockade Reduces Pathological Angiogenesis
Authors: Sandra Schoors, Katrien De Bock, Anna Rita Cantelmo, Maria Georgiadou, Bart Ghesquière, Sandra Cauwenberghs, Anna Kuchnio, Brian W. Wong, Annelies Quaegebeur, Jermaine Goveia, Francesco Bifari, Xingwu Wang, Raquel Blanco, Bieke Tembuyser, Ivo Cornelissen, Ann Bouché, Stefan Vinckier, Santiago Diaz-Moralli, Holger Gerhardt, Sucheta Telang, Marta Cascante, Jason Chesney, Mieke Dewerchin, Peter Carmeliet
Journal: Cell Metabolism (2013)
Lower respiratory infection and inflammation in infants with newly diagnosed cystic fibrosis
Authors: D. S Armstrong, K. Grimwood, R. Carzino, J. B Carlin, A. Olinsky, P. D Phelan
Journal: BMJ (1995)

95% confidence interval 1 1 to 12-6).Of 16 women whose menopause was the result of oophorectomy at 45 years or later, none had macular degeneration.This indicates a significant excess risk of early com- pared with late menopause by oophorectomy (exact lower 95% confidence limit 1X7).
Appendectomies During Physicians' Boycott
Authors: Robert H. Pantell
Journal: JAMA (1979)

The 1975 San Francisco physicians' boycott caused major changes in patterns of providing surgical care, but there was no appreciable change in the number of appendectomies performed during the boycott month when compared with a six-month baseline period. The ratio of normal to inflamed appendices removed was no different during the boycott than it was during the control period, and no differences were noted in the percentage of cases perforating in the boycott month when compared with the control period. In addition, patients seeking care for appendicitis during the boycott month did not experience delays. The lack of change in the standard direct and indirect indicators used to monitor quality of care suggests no major lapses in appendicitis care occurred in San Francisco during the boycott.
Realism about mental illness
Authors: D. McLoughlin
Journal: BMJ (1995)

The documentary-realist tradition has long been acknowledged to be Britain's outstanding contribution to film. However, realism can be limiting as it is impossible in a single short film to show everything. Documentary film makers have to be selective about how they represent their subjects and what is included in and, perhaps more importantly, excluded from the final version. Viewers tend to be unaware of such inherent biases, particularly when the film has the imprimatur of an institution such as the BBC. A typical example of this phenomenon is Minders, a compelling series of self contained, fly on the wall documentaries about a community mental health team based in Battersea, south London.

The best, most provocative, and also most tendentious of the opening three programmes was the first—“Whose mind is it anyway?”—in which a young black Ghanaian man was compulsorily admitted to hospital and treated under section 2 of the Mental Health Act. When we first meet John Baptist, formerly Philip, …
Ultrastructural localization of pemphigus vulgaris and pemphigus foliaceus antigens in cultured human squamous carcinoma cells
Authors: M. AKIYAMA, T. HASHIMOTO, M. SUGIURA, T. NISHIKAWA
Journal: British Journal of Dermatology (1991)

Journal Article Ultrastructural localization of pemphigus vulgaris and pemphigus foliaceus antigens in cultured human squamous carcinoma cells Get access M. AKIYAMA, M. AKIYAMA Department of Dermatology, Shimizu City Hospital, Shizuoka, JapanDepartment of Dermatology, Keio University School of Medicine, Tokyo Search for other works by this author on: Oxford Academic Google Scholar T. HASHIMOTO, T. HASHIMOTO Department of Dermatology, Keio University School of Medicine, Tokyo Search for other works by this author on: Oxford Academic Google Scholar M. SUGIURA, M. SUGIURA Department of Dermatology, Shimizu City Hospital, Shizuoka, Japan Search for other works by this author on: Oxford Academic Google Scholar T. NISHIKAWA T. NISHIKAWA Department of Dermatology, Keio University School of Medicine, Tokyo Professor Takeji Nishkawa, Department of Dermatology, Keio University School of Medicine. Shinanomachi 35, Shinjuku, Tokyo 160, Japan. Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 125, Issue 3, 1 September 1991, Pages 233–237, https://doi.org/10.1111/j.1365-2133.1991.tb14746.x Published: 01 September 1991
RIGHT VENTRICULAR SYSTOLIC FUNCTION PREDICTED FROM RIGHT BUNDLE BRANCH BLOCK: VALIDATED BY CARDIAC MAGNETIC RESONANCE IMAGING
Authors: Santhosh Devarapally, Ammaar El-Sergany, Michael Sood, Ali Ahmad, Rahul Gaglani, John Heitner, Terrence Sacchi, Barry Saul
Journal: Journal of the American College of Cardiology (2014)
Patients’ ability to treat anaphylaxis using adrenaline autoinjectors: a randomized controlled trial
Authors: T. Umasunthar, A. Procktor, M. Hodes, J. G. Smith, C. Gore, H. E. Cox, T. Marrs, H. Hanna, K. Phillips, C. Pinto, P. J. Turner, J. O. Warner, R. J. Boyle
Journal: Allergy (2015)

Previous work has shown patients commonly misuse adrenaline autoinjectors (AAI). It is unclear whether this is due to inadequate training, or poor device design. We undertook a prospective randomized controlled trial to evaluate ability to administer adrenaline using different AAI devices.We allocated mothers of food-allergic children prescribed an AAI for the first time to Anapen or EpiPen using a computer-generated randomization list, with optimal training according to manufacturer's instructions. After one year, participants were randomly allocated a new device (EpiPen, Anapen, new EpiPen, JEXT or Auvi-Q), without device-specific training. We assessed ability to deliver adrenaline using their AAI in a simulated anaphylaxis scenario six weeks and one year after initial training, and following device switch. Primary outcome was successful adrenaline administration at six weeks, assessed by an independent expert. Secondary outcomes were success at one year, success after switching device, and adverse events.We randomized 158 participants. At six weeks, 30 of 71 (42%) participants allocated to Anapen and 31 of 73 (43%) participants allocated to EpiPen were successful - RR 1.00 (95% CI 0.68-1.46). Success rates at one year were also similar, but digital injection was more common at one year with EpiPen (8/59, 14%) than Anapen (0/51, 0%, P = 0.007). When switched to a new device without specific training, success rates were higher with Auvi-Q (26/28, 93%) than other devices (39/80, 49%; P < 0.001).AAI device design is a major determinant of successful adrenaline administration. Success rates were low with several devices, but were high using the audio-prompt device Auvi-Q.
Short-term Pulmonary Vasodilation With<scp>l</scp>-Arginine in Pulmonary Hypertension
Authors: Sanjay Mehta, Duncan J. Stewart, David Langleben, Robert D. Levy
Journal: Circulation (1995)

Background Endothelial dysfunction may contribute to the pathogenesis of pulmonary hypertension through impaired production of the endothelium-derived vasodilator nitric oxide (NO). l -Arginine, the substrate for NO synthase (NOS), has a vasodilatory effect in systemic vascular beds and can correct abnormal endothelium-dependent vasodilation. It has been suggested that these two effects of l -arginine are mediated through NOS metabolism and enhanced NO production. Therefore, we assessed the short-term pulmonary hemodynamic effects of exogenous l -arginine in patients with pulmonary hypertension of various origins. Methods and Results During continuous hemodynamic monitoring, 10 subjects with pulmonary hypertension (mean pulmonary artery pressure [PAP], 54±5 mm Hg [mean±SEM]) received a 30-minute control infusion of hypertonic saline followed by a 30-minute infusion of 500 mg/kg of l -arginine. The hemodynamic effects of l -arginine were compared with those of prostacyclin titrated to maximally tolerated doses. The hemodynamic response to l -arginine was also studied in 5 subjects with heart failure but without pulmonary hypertension (mean PAP, 20±2 mm Hg) and 5 healthy control subjects. In subjects with pulmonary hypertension, infusion of l -arginine reduced mean PAP by 15.8±3.6% ( P &lt;.005) and pulmonary vascular resistance (PVR) by 27.6±5.8% ( P &lt;.005) compared with decreases of 13.0±5.5% ( P &lt;.005) and 46.6±6.2% ( P &lt;.005), respectively, with prostacyclin. l -Arginine infusion also increased the mean plasma level of l -arginine from 59±6 μmol/L to 10 726±868 μmol/L ( P &lt;.005), which was associated with a significant increase in the plasma level of l -citrulline, the immediate product of NOS metabolism of l -arginine. Moreover, the peak plasma level of l -citrulline correlated significantly with the reductions in mean PAP ( r =.71, P &lt;.05) and PVR ( r =.70, P &lt;.05), consistent with vasodilation mediated by NOS metabolism of exogenous l -arginine and increased NO production. l -Arginine also had a modest hypotensive effect in healthy control subjects and reduced systemic vascular resistance in subjects with heart failure in the absence of pulmonary hypertension. However, only small reductions in absolute pulmonary vascular resistance were observed in this latter group in response to l -arginine that did not reach significance. Conclusions An exaggerated short-term pulmonary vasodilatory response to l -arginine in patients with pulmonary hypertension suggests a relative impairment in pulmonary vascular endothelial NO production that may contribute to increased pulmonary vascular tone and thus be important in the pathophysiology of pulmonary hypertension.
Healing by Design
Authors: C R Horsburgh
Journal: New England Journal of Medicine (1995)

Medical care cannot be separated from the buildings in which it is delivered. The quality of space in such buildings affects the outcome of medical care, and architectural design is thus an important part of the healing process. This article explores the relation between spatial design and healing by focusing on recent developments in the design of hospitals in the United States.The number of U.S. hospitals grew steadily from 6125 in 1945 to 7174 in 1974, an increase of 17 percent.1 Since 1975, however, there has been a continuous decline in numbers, to 6467 in 1993, while the average . . .
The Internist and Industrial Injuries.
Authors: Raymond A. Sokolow
Journal: Annals of Internal Medicine (1966)

s1 May 1966The Internist and Industrial Injuries.Raymond A. Sokolow, M.D., F.A.C.P.Raymond A. Sokolow, M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-64-5-1175_2 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptDisabling industrial injuries are more prevalent and less responsive to treatment than ever before, despite improved working conditions and the efforts of a growing corps of safety engineers, industrial physicians, and rehabilitation specialists. This results from a failure to recognize and treat the accident victim's emotional and personal problems, which are involved in causation of injury and which prevent recovery. The internist, because he deals with the whole person, is uniquely qualified to manage industrial injuries.A group of internists and psychiatrists, working in seminar, with an internist in charge of each case, treated 50 industrial injuries. Orthopedists and other... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: Raymond A. Sokolow, M.D., F.A.C.P.Affiliations: Detroit, Michigan PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 May 1966Volume 64, Issue 5Page: 1175-1175KeywordsEmotionsEngineersSafety ePublished: 1 December 2008 Issue Published: 1 May 1966 PDF downloadLoading ...
Human effector CD8+ T cells derived from naive rather than memory subsets possess superior traits for adoptive immunotherapy
Authors: Christian S. Hinrichs, Zachary A. Borman, Luca Gattinoni, Zhiya Yu, William R. Burns, Jianping Huang, Christopher A. Klebanoff, Laura A. Johnson, Sid P. Kerkar, Shicheng Yang, Pawel Muranski, Douglas C. Palmer, Christopher D. Scott, Richard A. Morgan, Paul F. Robbins, Steven A. Rosenberg, Nicholas P. Restifo
Journal: Blood (2010)
Chewing gum for extradural haemorrhage
Authors: A. Coutts
Journal: BMJ (1998)

From 1984 to 1986 I had the privilege of being chief medical officer (surgery) and consultant surgeon in the Solomon Islands.The country lies in the western Pacific, south east of Papua New Guinea, and has a population of about 250 000.I was its only surgeon, based at Central Hospital, Honiara, on Guadalcanal, one of the many islands.
Synthesis and Properties of Angiotonin
Authors: F. MERLIN BUMPUS, HANS SCHWARZ, IRVINE H. PAGE
Journal: Circulation (1958)

Angiotonin has been shown to be formed by a converting enzyme in blood by the splitting off of the 2 amino acids histidine and leucine from the inactive decapeptide (asp-arg-val-tyr-ileu-his-prol-phe-his-leuc). The synthesis of the active octapeptide is described and its pharmacologic resemblance to the natural product is demonstrated.
A Case of Secondary Hemochromatosis With High Uptake of Liver in F-18 FDG PET/CT Imaging
Authors: Kimiteru Ito, Ryogo Minamimoto, Miyako Morooka, Kazuo Kubota
Journal: Clinical Nuclear Medicine (2011)

Hemochromatosis is an iron storage disorder with progressive and massive deposition of iron in the parenchymal cells of various organs. A 72-year-old woman with rheumatoid arthritis diagnosed with secondary hemochromatosis underwent F-18 fluorodeoxyglucose (FDG) positron emission tomography(PET)/computed tomography (CT) to search for malignancy. F-18 FDG PET/CT incidentally showed homogeneous and high FDG uptake (mean SUV, 4.8) in the liver with high density. FDG uptake seemed to be reflected by the functional abnormality of liver. Hemochromatosis should be considered when making a diagnosis of homogeneous high F-18 FDG uptake in liver with high density on CT image.
Demonstration of dissimilar acute haemodynamic effects of ethanol and acetaldehyde
Authors: H. S. FRIEDMAN, S. MATSUZAKI, S.-S. CHOE, H. A. FERNANDO, A. CELIS, Q. ZAMAN, C. S. LIEBER
Journal: Cardiovascular Research (1979)

To determine whether the acute cardiac depressant effects of ethanol could be attributed to its metabolite (acetaldehyde), either ethanol or acetaldehyde was intravenously infused into pentobarbital anaesthetised, closed-chest dogs. At a venous blood ethanol level of 199±43 (SE) mg·dl−1, ejection fraction had decreased from 35±2 to 30±2%, P <0.05, max dP/dt/end-diastolic volume from 14.0±2.1 to 8.6 ± 1.1 kPa·s−1·cm−3 (105 ± 16 to 65±8 mmHg·s−1·cm−3), P<0.02, whereas end-diastolic volume (P <0.005), myocardial oxygen consumption (P <0.05) and coronary blood flow (P <0.005) had increased. Higher ethanol levels exaggerated these changes when peak arterial acetaldehyde was 20.2 ±4 (μmol·litre−1. By contrast, infusion of acetaldehyde to a peak blood level comparable with that produced by ethanol increased cardiac output from 2.4±0.2 to 2.8 ±0.2 litre·min−1 (P<0.01), coronary sinus oxygen saturation from 46±4 to 55±3% (P<0.25) and reduced systemic resistance from 8.0±0.7 to 6.3±0.5 kPa·litre −1·min−1 (60±5 to 47±4 mmHg·litre−1·min−1) (P<0.001). High dosage of acetaldehyde to a level of 129 ±23 μmol·litre−1 produced elevation of cardiac output (P<0.001), ejection fraction (P<0.01), coronary blood flow (P<0.02), whereas systemic resistance (P <0.001), heart rate (P <0.05) and myocardial oxygen consumption (P <0.05) decreased. Discontinuation of acetaldehyde infusion significantly reversed these changes. Max dP/dt/left ventricular end-diastolic volume and left ventricular end-diastolic volume were not significantly altered by acetaldehyde. Thus, ethanol depresses cardiac performance and increases myocardial oxygen consumption. By contrast, acetaldehyde at levels produced by ethanol metabolism improves cardiac performance, consequent to afterload reduction, and reduces myocardial oxygen consumption.