THE ETIOLOGY OF PERNICIOUS ANEMIA AND RELATED MACROCYTIC ANEMIAS
Authors: W. B. Castle
Journal: Annals of Internal Medicine (1933)

Article1 July 1933THE ETIOLOGY OF PERNICIOUS ANEMIA AND RELATED MACROCYTIC ANEMIASW. B. CASTLE, F.A.C.P.W. B. CASTLE, F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-7-1-2 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptDuring the past five years the problem of the etiology of pernicious anemia and other macrocytic anemias responding to liver extract has been investigated at the Thorndike Memorial Laboratory, Boston City Hospital. At various times Dr. Wilmot C. Townsend, Dr. Clark W. Heath, Dr. Maurice B. Strauss and myself have been engaged in this study. Last year, in collaboration with Dr. C. P. Rhoads of the Rockefeller Hospital, the macrocytic anemia of sprue in Puerto Rico was studied under the auspices of the Rockefeller Foundation. Recently Dr. Strauss has investigated the mechanism of the pernicious anemia of pregnancy.The technic...Bibliography1. CASTLELOCKE WBEA: Observations on the etiological relationship of achylia gastrica to pernicious anemia, Jr. Clin. Investigation, 1928, vi, 2. Google Scholar2. CASTLE WB: Observations on the etiologic relationship of achylia gastrica to pernicious anemia. I. The effect of the administration to patients with pernicious anemia of the contents of the normal human stomach recovered after the ingestion of beef muscle, Am. Jr. Med. Sci., 1929, clxxviii, 748-764. CrossrefGoogle Scholar3. CASTLETOWNSEND WBWC: Observations on the etiologic relationship of achylia gastrica to pernicious anemia. II. The effect of the administration to patients with pernicious anemia of beef muscle after incubation with normal human gastric juice, Am. Jr. Med. Sci., 1929, clxxviii, 764-777. CrossrefGoogle Scholar4. 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Activation of yeast derivatives with normal human gastric juice, New Eng. Jr. Med., 1932, ccvii, 55-59. CrossrefGoogle Scholar7. ELDERS C: Tropical sprue and pernicious anemia, etiology and treatment, Lancet, 1925, i, 75-77. CrossrefGoogle Scholar8. ASHFORD BK: Sprue, Ann. Clin. Med., 1925, iv, 13-20. Google Scholar9. CASTLERHOADS WBCP: The etiology and treatment of sprue in Porto Rico, Lancet, 1932, i, 1198-1199; Trans. Assoc. Am. Phys., 1932, xlvii, 245. CrossrefGoogle Scholar10. WILLS L: Treatment of "pernicious anemia of pregnancy" and "tropical anemia" with special reference to yeast extract as a curative agent, British Med. Jr., 1931, i, 1059-1064. CrossrefGoogle Scholar11. VAUGHANHUNTER JMD: The treatment by marmite of megalocytic hyperchromic anemia occurring in idiopathic steatorrhea (celiac disease), Lancet, 1932, i, 829-834. CrossrefGoogle Scholar12. STRAUSS MB: Observations on the etiology and treatment of anemia in pregnancy, Jr. Clin. Investigation, 1932, xi, 809-810. Google Scholar13. STRAUSSCASTLE MBWB: Studies of anemia in pregnancy. III. The etiologic relationship of gastric secretory defects and dietary deficiency to the hypochromic and macrocytic (pernicious) anemias of pregnancy and the treatment of these conditions, Am. Jr. Med. Sci., 1933, clxxxv, 539-551. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Boston, Massachusetts*Address delivered by Dr. W. B. Castle as recipient of the John Phillips Memorial Prize at the Montreal Meeting of the American College of Physicians, February 6, 1933.From the Thorndike Memorial Laboratory and the Second and Fourth (Harvard) Medical Services of the Boston City Hospital, and the Department of Medicine of the Harvard Medical School. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byThe Diagnosis and Treatment of Pernicious AnemiaStudies on Castle's Extrinsic FactorExtrinsic Factor in Pernicious Anemia: Ineffectiveness of Purified Casein and of Identified Components of the Vitamin B ComplexRecent advances in the anemias of infancy and childhoodThe proteolytic effect of normal gastric juice on beef muscle globulin, with reference to the reported action of the anti-anemic intrinsic factorThe relation of gastrectomy to anemiaBeitrag zur Pathogenese der ZiegenmilchanämineDer Mechanismus der Vitaminwirkungen 1 July 1933Volume 7, Issue 1Page: 2-5KeywordsAnemiaEtiologyHospital medicineLiverMedical servicesPernicious anemiaPregnancyResearch laboratories ePublished: 1 December 2008 Issue Published: 1 July 1933 PDF downloadLoading ...