THE TREATMENT OF BARBITURATE INTOXICATION WITH SPECIAL REFERENCE TO PICROTOXIN; A REPORT OF 20 CASES
Authors: John P. Anderson
Journal: Annals of Internal Medicine (1941)

Article1 May 1941THE TREATMENT OF BARBITURATE INTOXICATION WITH SPECIAL REFERENCE TO PICROTOXIN; A REPORT OF 20 CASESJOHN P. ANDERSON, M.D., F.A.C.P.JOHN P. ANDERSON, M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-14-11-2037 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe clinical use of picrotoxin in combating acute barbiturate intoxication is sufficiently new that an experience with 20 cases of this type, observed during the last year and a half, may prove of value. In recent years, the taking of large quantities of barbiturates of various kinds has become an increasingly popular method of attempting suicide. In all of the cases to be described, the barbiturate was taken with suicidal intent, and the patients were seen and treated on the medical services of St. Vincent's Charity and Glenville Hospitals, in Cleveland.Although Browne1discovered, in 1875, that picrotoxin protected rabbits...References1. BROWNE JC: On the actions of picrotoxine and the antagonism between picrotoxine and chloral hydrate, Brit. Med. Jr., 1875, i, 409-411, 442-444, 506-542. CrossrefGoogle Scholar2. MALONEYFITCHTATUM AHRHAL: Picrotoxin as antidote in acute poisoning by shorter acting barbiturates, Jr. Pharm. and Exper. Therap., 1931, xli, 465-482. Google Scholar3. MALONEYTATUM AHAL: Picrotoxin as antidote in acute poisoning by shorter acting barbiturates, Jr. Pharm. and Exper. Therap., 1932, xliv, 337-352. Google Scholar4. ARNETT JH: Ephedrine and picrotoxin used successfully in amytal poisoning, Jr. Am. Med. Assoc., 1933, c, 1593. CrossrefGoogle Scholar5. KOPPANYILINEGARDILLE TCRJM: Studies on barbiturates. XIX. Analysis of barbiturate-picrotoxin antagonism, Jr. Pharm. and Exper. Therap., 1936, lviii, 199-228. Google Scholar6. KLINEBIGGWHITNEY EMEHA: Picrotoxin in the treatment of barbiturate poisoning: report of a case, Jr. Am. Med. Assoc., 1937, cix, 328-330. CrossrefGoogle Scholar7. GOWERVAN DE ERVE WEJ: Recovery from experimental barbital poisoning and various types of fluid administration, Jr. Pharm. and Exper. Therap., 1938, xlviii, 141-147. Google Scholar8. BLECKWENNMASTEN WJMG: The antidotal treatment of barbiturate intoxication: report of treatment with picrotoxin in six cases, Jr. Am. Med. Assoc., 1938, cxi, 504-507. CrossrefGoogle Scholar9. ROVENSTINE EA: The antidotal action of picrotoxin in acute intoxication by the barbiturates, Am. Jr. Med. Sci., 1938, cxcvi, 46. CrossrefGoogle Scholar10. LOVIBONDSTEEL JLGC: Picrotoxin in the treatment of barbiturate intoxication: with report of a case, Lancet, 1939, ccxxxvii, 561. CrossrefGoogle Scholar11. STEPHENSANDERSON JTJP: Picrotoxin in the treatment of barbiturate intoxication: with report of a case, Ohio State Med. Jr., 1939, xxxv, 396-398. Google Scholar12. LANCASTER AH: Luminal dermatitis with case reports, South. Med. Jr., 1932, xxv, 1142. CrossrefGoogle Scholar13. DOUGHERTY MS: Toxic reactions produced by the derivatives of barbituric acid, South. Med. Jr., 1932, xxv, 1145. CrossrefGoogle Scholar14. MARRI R: Acute poisoning by barbituric hypnotics, Policlinico, sez. prat., 1939, xlvi, 771. Google Scholar15. NOVY FG: Drug eruptions due to the barbiturates, California and Western Med., 1938, xlviii, 324. Google Scholar16. COSTEBOLGERT FM: Ulcerations due to barbituric acid preparations, Bull. et mém. Soc. méd. d. hôp. de Paris, 1933, xlix, 779. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Cleveland, Ohio*Read at the Cleveland meeting of the American College of Physicians, April 3, 1940. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byBarbiturate PoisoningReferencesTHERAPY OF ACUTE BARBITURATE POISONING: REPORT OF THREE CASES*MARCEL ROCHE, M.D., LYMAN C. WYNNE, M.D., DONALD M. HASKINS, M.D.The present status of analeptics * *From The George Washington University, School of Pharmacy, Washington, D. C. † †This is the sixth of a series of review articles. Part of the cost of publication of this series of review articles is paid from the treasury of the National Conference on Pharmaceutical Research. 1 May 1941Volume 14, Issue 11Page: 2037-2046KeywordsIntoxicationMedical servicesRabbitsSuicide ePublished: 1 December 2008 Issue Published: 1 May 1941 PDF downloadLoading ...