tbuckley/cabot-search huggingface dataset:
ABNORMAL COLLAGEN TURNOVER AND MMP-9 ARE THE COMMON LINK BETWEEN INCREASED ARTERIAL STIFFNESS, IMPAIRED CORONARY FLOW RESERVE AND LV UNTWISTING IN UNTREATED PATIENTS WITH ESSENTIAL HYPERTENSION
Authors: Ignatios Ikonomidis, John Lekakis, Stavros Tzortzis, Costas Papadopoulos, Ioannis Paraskevaidis, Helen Triantafyllidi, Paraskevi Trivilou, Dimitrios Th Kremastinos
Journal: Journal of the American College of Cardiology (2010)
The Medical Profession in 1837
Authors: D. Power
Journal: BMJ (1897)

MDTIxAL 16U7rstracts of really important papers could be obtained, whilst the discussions at the Societies went unreported, not so much from the want of a good system of stenography-for Pitman invented his system in I837-as from the danger of personal violence run by the reporter if he was detected in the act of making notes.
Endoscopic submucosal dissection of esophageal cancer using the Mucosectom2 device: a feasibility study
Authors: Yoshiro Kawahara, Keisuke Hori, Ryuta Takenaka, Junichiro Nasu, Seiji Kawano, Masahide Kita, Takao Tsuzuki, Minoru Matsubara, Sayo Kobayashi, Hiroyuki Okada, Kazuhide Yamamoto
Journal: Endoscopy (2013)

Endoscopic submucosal dissection (ESD) is being increasingly used for superficial esophageal cancers. However, esophageal ESD is technically difficult, time consuming, and less safe compared with endoscopic mucosal resection (EMR). To perform ESD safely and more efficiently, various types of knives have been developed. This study compared the efficacy of our newly developed device, Mucosectom2, with that of conventional devices for esophageal ESD.Between May 2007 and February 2011, ESD was performed for 172 esophageal lesions. Of these, 120 lesions were treated by conventional devices only, whereas 52 lesions were treated by conventional devices and the Mucosectom2. Procedure time, en bloc and R0 resection rates, and adverse events were retrospectively compared between the conventional and Mucosectom2 groups.The median procedure time was 48.0 minutes in the conventional group and 21.5 minutes in the Mucosectom2 group; the procedure time was significantly shorter in the Mucosectom2 group than in the conventional group (P < 0.0001). The en bloc and R0 resection rates were lower in the conventional group than those in the Mucosectom2 group, although these differences were not significant. The rate of exposure of the muscle layer in the Mucosectom2 group was significantly lower than in the conventional group (P = 0.04). The rates of perforation and postoperative bleeding were not significantly different between the two groups.This feasibility study suggests that, compared with conventional ESD devices, the Mucosectom2 may decrease the time required for esophageal ESD. Although our groups appeared comparable, they were studied at different times. Endoscopic expertise and endoscope quality may have differed during these periods, thereby affecting the results of our study. A prospective trial is therefore required to confirm our results.
Giving more information about drug treatment.
Authors: V. Schnieden
Journal: BMJ (1992)

Charlton and Cuninghame propose regular standard quality checks on computer health records, but this should be cost effective.We fear that the authors underestimate the effort and resources required in manual checking.3In the future, electronic reconciliation of data on patients held on different computers must be pursued.6In the meantime, we suggest that regular feedback of data to general practitioners is likely to improve accuracy and to encourage a higher rate of immunisation in the target populationthe prime objective.Finally, we agree that computers, like humans, should be immunised against attack by viruses.7
Limb length discrepancy in cutis marmorata telangiectatica congenita: an audit of assessment and management in a multidisciplinary setting
Authors: A. Memarzadeh, I. Pengas, S. Syed, D.M. Eastwood
Journal: British Journal of Dermatology (2013)

Cutis marmorata telangiectatica congenita (CMTC) is a vascular malformation, diagnosed based on cutaneous manifestations. It is associated with limb length discrepancy (LLD) and asymmetry, but the exact extent of this and its relationship to the site of the cutaneous manifestations have not been delineated.To review the orthopaedic problems associated with CMTC, concentrating on the assessment and management of the LLD.This study is a retrospective analysis of orthopaedic, dermatological and vascular data that were collected prospectively at our tertiary referral centre. We identified 80 patients with an initial diagnosis of CMTC; 57/69 patients with a confirmed diagnosis had lower-limb involvement.An LLD was identified in 51% of cases. The discrepancy was significant (defined as ≥ 2 cm) in nine patients and was confirmed using standing leg-length radiographs. Of these patients, three had epiphysiodesis to correct the discrepancy, and surgery is planned in five others.Limb length discrepancy and asymmetry are common in CMTC; however, this is below the significant threshold in most cases. It is therefore recommended that any discrepancy be initially monitored clinically. This should be followed by standing leg-length radiographs at the age of 10 years (girls) or 12 years (boys), or if the LLD is ≥ 2 cm. If this is confirmed radiologically, orthopaedic referral is advised to consider surgical intervention such as epiphysiodesis.
Vaccination against Variola
Authors: G. Friedlaender
Journal: BMJ (1947)

apparent slight hyperaesthesia proximal to the line of demarcation, which might be explained by the band of hyperaemia as described by Gelfand.Knee-jerks were indeterminate.Wassermann examina- tion and blood counts could not be performed.The urine was free of sugar and albumin.The patient refused operation and would not enter hospital, so his further progress is not known.Williams (1939), discussing the results of 894 post-mortem examinations in Uganda, found 86 cases showing syphilitic arterial disease and considers that this is common in East Africa.Coombs (1932) points out that lesions most commonly follow one, two, or more decades after infection.This would fit in with the age groups of beth Gelfand's and my cases, particularly when it is remembered that the African often acquires his syphilis relatively early in life.Prior to Gelfand's paper I had considered my case to be definitely one of syphilitic origin.Now the question requires reconsideration.It may be that the part played by syphilis is merely an initial damage to the artery (Gordon et al., 1942), on which further processes later briiig about an ischaemia sufficiently suddenly to cause gangrene.On the other hand in cases where gangrene has followed syphilis the onset has usually been much less, sudden than in these seven cases.Choussat (1938), for instance, describes a ese of bilateral dry gangrene of the feet, of slow onset, in a child of 10.Bilateral gangrenous areas on the arms of a white woman of 61, in which the lesion on the left preceded that on the right, is cited by Goodman (1939).Similar cases will be found in papers by Fusco and Kell (1943) and Leone Bloise (1936), though I havepersonally not yet been able to trace them.When the high rate of syphilis in certain native populations is taken into account, figures ranging from 23% (Kark and Le Riche, 1944) to 40% (Rauch and Saayman, 1938) being sub- stantiated by various authors, the fact that three out of these seven cases of bilateral gangrene of the feet had syphilis may not be of significance but merely a coincidental finding.-Iam, etc.,
The Pulmonary Vein Wedge Pressure in Man
Authors: DANIEL C. CONNOLLY, EARL H. WOOD
Journal: Circulation Research (1955)

In 12 patients with atrial septal defect or anomalous pulmonary venous connection, pulmonary vein wedge mean pressure uniformly exceeded mean pressure in the left atrium or pulmonary vein and with one exception was less than mean pressure in the pulmonary artery. There was a positive correlation between pulmonary arteriolar resistance and the difference in pressure between pulmonary artery and pulmonary vein wedge position. The oxygen saturation of blood, withdrawn from the pulmonary vein wedge position, uniformly exceeded that of left atrial and usually also that of pulmonary vein blood.
The Impact of First-Responder Defibrillation
Authors: Ian G. Stiell
Journal: JAMA (1994)

<h3>To the Editor.</h3> —We applaud the efforts of Kellermann et al<sup>1</sup>to elucidate the relative efficacy of first-response defibrillation on survival after out-of-hospital cardiac arrest. They have used an elegant method to study a difficult issue. Nevertheless, we would like to raise a few concerns about their study. First, the low percentage of patients in the defibrillator arm of the study actually receiving automatic defibrillation may bias the study toward finding no significant difference in survival between groups. The patients receiving automatic defibrillation had a statistically significant slower paramedic response time than those not receiving it within the treatment arm. The lack of benefit from first-responder defibrillation in Memphis, Tenn, may then reflect the negative effect of longer paramedic response times rather than inefficacy of early defibrillation. Alternatively, it may reflect the fact that firefighters clearly arrived first only 50% of the time because of the very rapid response
The Dilemmas of Mothers Who Are Physicians and of Physicians Who Are Mothers
Authors: Heidi Thaens
Journal: JAMA (1986)

To the Editor.—  To Anonymous, who in the Aug 16 issue of JAMA  1 expresses anguish over the conflicting claims of motherhood and her career (as well as  and athletic activities), I would like to say the following. Being grown up means, among other things, knowing how to set realistic priorities, and this naturally involves making some sacrifices. (To imagine that one can have it all is simply immature and greedy.) As the mother of two now fully grown, exceptionally sane, much loved children, I can look back on some years of severe financial disequilibrium, stress, and anxiety during our family's first decade. Throughout that period of unanticipated adversity, my husband and I both often felt melancholy, inadequate, guilt ridden, and desperate; certainly social and athletic activities never entered the picture. The difference between me and Anonymous is that I had been dreaming of becoming a mother since age 8
Pharmacoeconomic Analyses
Authors: Drummond Rennie, Harold S. Luft
Journal: JAMA (2000)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
PROSTATIC DILATING IRRIGATOR.
Authors: F. A. LEUSMAN
Journal: JAMA (1901)

The high price and expensive repairs of the Kollmann dilating irrigator led me to construct an irrigating prostatic dilator from the type of Leonard's uterine dilating irrigator. Adapting the instrument to the anatomy of the parts, confining the area of dilatation to the prostatic urethra and attaching separate shut-offs for the in-flow and out-flow, resulted in the production of this instrument, that in my hands has proven an efficient dilator—it dilates up to 45 F.—and irrigator. By carrying the amount of dilatation in the use of this instrument to a no higher degree than the patient can willingly or comfortably endure, we are enabled to express the mucus plugs and pus from out of the prostatic follicles, wash and clean the parts thoroughly with a 4 per cent, sterilized boric acid solution (95 F.) and then apply by means of Guyon's catheter, a few drops of a stimulating solution of
Therapy with Cromolyn Sodium
Authors: I. LEONARD BERNSTEIN
Journal: Annals of Internal Medicine (1978)

Cromolyn is a prototype of a new series of drugs, the pharmacologic activities of which may offer an entirely new approach in the treatment of asthma. Whereas bronchodilator drugs and steroids act primarily at tissue sites to counteract the effects of various toxic mediators released from tissue mast cells, cromolyn prevents the release of such mediators from mast cell membranes. The advent of cromolyn sodium therapy has been recognized as a significant advance by the pharmaceutical industry, which is rapidly developing a series of cromolyn-like drugs with similar properties. Many of these compounds are active orally, and some preliminary investigations suggest that they also could be clinically effective. Cromolyn has therapeutic value in immunologic and nonimmunologically induced bronchospasm, being particularly suited for conditions amenable to long-term prophylactic therapy. The risk-to-benefit ratio of cromolyn sodium therapy is excellent. Cromolyn sodium is an important adjunct in the treatment of asthma. By topical administration the drug has been effective in seasonal and perennial rhinoconjunctivitis and in selected cases of gastrointestinal allergy to foods.
Patient's consent to abortion is usually necessary even in emergencies
Authors: M. Puxon
Journal: BMJ (1996)

will be made available to vendors of general practitioner and hospital software for incorporation in their systems, whether on DOS or other platforms.Copies of the BNF are purchased by the Department of Health in bulk and then provided free to doctors and pharmacists working for the NHS.No such arrangement exists at present for the electronic version, which is available only through the publishers (BMA and the Royal Pharmaceutical Society ofGreat Britain).The stand alone eBNF runs adequately on personal computers with a 386 processor, though a more powerful processor and more memory will increase its speed.The stand alone eBNF is run from the hard disk.Most new non-clinical software that clinicians may want to use runs under Win- dows; users are therefore likely to replace their systems with newer hardware that will run such software.
Problem of violence against women with HIV is unacknowledged, say researchers
Authors: S. Arie
Journal: BMJ (2013)

The authors of a new study have called for recognition and specialised support for women suffering from both HIV and gender based violence (GBV).

“For women experiencing this there really needs to be specialist case management,” said Jane Hutchinson, the study’s coauthor. The study looks at the feasibility of a full investigation into the problem,1 and is published by the Sophia Forum, a network of organisations in the United Kingdom that promote women’s health.

The link between HIV and GBV has been widely researched internationally, but in the UK the problem is “under-researched and relatively unacknowledged,” the …
Stress Management: A Multimodal Approach
Authors: Joan Roberts Field, Harry Olsen
Journal: Psychotherapy and Psychosomatics (1980)

This newly developed stress-management program evolved from study of the three major trends in stress research: psychological, physiological and sociological. Primarily geared to managers in an industrial setting, this program helps the individuals to reduce physiological tension via autohypnosis and alter stress-producing behaviors through a number of cognitive restructuring techniques. A variety of philosophical issues are raised that relate to 'type A' behavior focusing on 'the hurry syndrome', aggression and a general balance in 'life tasks'. In addition, there is an educational component and participants are acquainted with their 'health probabilities' in terms of life style, weight, smoking and other factors. This multimodal program follows participants over a 2-year period to reinforce psycho-behavioral changes.
Cardiac evaluation in hypotension-prone and hypotension-resistant hemodialysis patients
Authors: Don Poldermans, Arie J. Man In 't Veld, Riccardo Rambaldi, Anton H. van den Meiracker, Marinus A. van den Dorpel, Guido Rocchi, Eric Boersma, Jeroen J. Bax, Willem Weimar, Jos R.T.C. Roelandt, Robert Zietse
Journal: Kidney International (1999)
A Hazard of Protein-Sparing Modified Fast
Authors: Alvin Shemesh
Journal: JAMA (1978)

<h3>To the Editor. —</h3> An overweight, 60-year-old woman came in complaining of sudden onset of diarrhea, shortness of breath, and lower abdominal pain. She related a history of placing herself on a liquid protein fast with a kit obtained at a local nutrition store. Among the pills that came with the regimen were vitamins, calcium, iron, folic acid, and potassium. An x-ray film of the abdomen (Figure) showed approximately 18 to 20 undissolved tablets in the colon. Her serum potassium level was 2.8 mEq/liter. An ECG pattern showed a sinus arrhythmia with a T-wave abnormality (U-wave) indicative of an electrolyte disturbance, most likely hypokalemia. This x-ray film demonstrates that among the hazards of self-imposed fast is the possibility of the insolubility of medications purchased from various sources. Notably hazardous are potassium compound tablets that may be enterically insoluble, producing a severe electrolyte disturbance.
Cancer-Suppressing Mutation
Authors: Tracy Hampton
Journal: JAMA (2007)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
STANDARDS IN ROENTGENOLOGY
Authors: P. M. HICKEY
Journal: JAMA (1927)

Roentgenology has won a place for itself in the diagnosis and treatment of disease until it has now come to be recognized as an important specialty. It is therefore appropriate that the Section on Radiology consider what is to be expected of the members of this new branch of medicine.  As the students of today are the physicians of tomorrow it is fitting that this section discuss the problem of standards of teaching roentgenology to medical students. Since the various bodies governing medical education have definitely assigned in the curriculum the number of hours proportionate to the importance of roentgenology, it is proper that there should be presented to the various teachers a comprehensive plan for the employment of these hours. Their task is to make the medical student of today acquainted with the established facts in roentgen-ray diagnosis and in roentgen-ray therapy, so that his future patients may derive
Hormones and breast cancer: controlling the danger within
Authors: Hema Bashyam
Journal: The Journal of Experimental Medicine (2007)

For the first half of the 20th century, the effects of sex hormones on breast cancer were poorly understood due to the lack of an animal model. In 1959, Charles Huggins devised a method to induce hormone-responsive mammary cancers in rats. The model paved the way for new treatment and prevention strategies for breast cancer.
Response of Failing Canine and Human Heart Cells to β <sub>2</sub> -Adrenergic Stimulation
Authors: Ruth A. Altschuld, Randall C. Starling, Robert L. Hamlin, George E. Billman, James Hensley, Lourdes Castillo, Richard H. Fertel, Charlene M. Hohl, Pierre-Marie L. Robitaille, Larry R. Jones, Rui-Ping Xiao, Edward G. Lakatta
Journal: Circulation (1995)

Background Failing human hearts lose β 1 - but not β 2 -adrenergic receptors. In canine hearts with tachypacing failure, the ratio of β 2 - to β 1 -adrenergic receptors is increased. The present study was designed to determine whether heart failure increases sensitivity to β 2 -adrenergic stimulation in isolated canine ventricular cardiomyocytes and to verify that myocytes from failing human ventricles contain functional β 2 -adrenergic receptors. Methods and Results Myocytes from healthy dogs, dogs with tachypacing failure, and human transplant recipients were loaded with fura 2-AM and subjected to electric field stimulation in the presence of zinterol, a highly selective β 2 -adrenergic agonist. Zinterol significantly increased [Ca 2+ ] i transient amplitudes in all three groups. The failing canine myocytes were significantly more responsive than normal to β 2 -adrenergic stimulation. We also measured isotonic twitches, indo-1 fluorescence transients, and L-type Ca 2+ currents in healthy canine myocytes. Zinterol (10 −5 mol/L) elicited large increases in the amplitudes of simultaneously recorded twitches and [Ca 2+ ] i transients. Zinterol also increased L-type Ca 2+ currents in the normal canine myocytes; this augmentation was abolished by 10 −7 mol/L ICI 118,551. cAMP production by suspensions of healthy and failing canine myocytes was not increased by zinterol (10 −9 to 10 −5 mol/L), nor did 10 −5 mol/L zinterol elicit phospholamban phosphorylation. Conclusions Failing human ventricular cardiomyocytes contain functional β 2 -adrenergic receptors. Canine myocytes also contain functional β 2 -adrenergic receptors. The canine ventricular response to β 2 -agonists is increased in tachypacing failure. Positive inotropic responses to β 2 -stimulation are not mediated by increases in cAMP or cAMP-dependent phosphorylation of phospholamban.
Gains of glycosylation comprise an unexpectedly large group of pathogenic mutations
Authors: Guillaume Vogt, Ariane Chapgier, Kun Yang, Nadia Chuzhanova, Jacqueline Feinberg, Claire Fieschi, Stéphanie Boisson-Dupuis, Alexandre Alcais, Orchidée Filipe-Santos, Jacinta Bustamante, Ludovic de Beaucoudrey, Ibrahim Al-Mohsen, Sami Al-Hajjar, Abdulaziz Al-Ghonaium, Parisa Adimi, Mehdi Mirsaeidi, Soheila Khalilzadeh, Sergio Rosenzweig, Oscar de la Calle Martin, Thomas R Bauer, Jennifer M Puck, Hans D Ochs, Dieter Furthner, Carolin Engelhorn, Bernd Belohradsky, Davood Mansouri, Steven M Holland, Robert D Schreiber, Laurent Abel, David N Cooper, Claire Soudais, Jean-Laurent Casanova
Journal: Nature Genetics (2005)