tbuckley/cabot-search huggingface dataset:
Prognostic relevance of 18-F FDG PET/CT in newly diagnosed multiple myeloma patients treated with up-front autologous transplantation
Authors: Elena Zamagni, Francesca Patriarca, Cristina Nanni, Beatrice Zannetti, Emanuela Englaro, Annalisa Pezzi, Paola Tacchetti, Silvia Buttignol, Giulia Perrone, Annamaria Brioli, Lucia Pantani, Carolina Terragna, Francesca Carobolante, Michele Baccarani, Renato Fanin, Stefano Fanti, Michele Cavo
Journal: Blood (2011)
Case 43-1985
Authors: Richard C. Cabot, Robert E. Scully, Eugene J. Mark, Betty U. Mcneely, Stuart J. Spechler, Gary C. Stone
Journal: New England Journal of Medicine (1985)

Presentation of CaseA 70-year-old man was admitted to the hospital because of chronic diarrhea and weight loss.He was in a stable state of health until three months earlier, when abdominal discomfort and bloating developed, followed by the passage of watery stools. On the following day he went to another hospital, where atrial fibrillation was found and he was admitted.The patient was a retired mechanic for a commercial airline. He had smoked cigarettes in the past but had discontinued smoking 15 years earlier. A transurethral resection of the prostate gland was performed four years before admission, and urethral . . .
Late Left Ventricular Function After Surgery for Children With Chronic Symptomatic Mitral Regurgitation
Authors: Usha S. Krishnan, Welton M. Gersony, Erika Berman-Rosenzweig, Howard D. Apfel
Journal: Circulation (1997)

Background The use of quantitative echocardiography has been emphasized in optimizing timing of surgery in adult patients with mitral regurgitation to avoid irreversible left ventricular dysfunction. In contrast, surgery for infants and children is often delayed until the appearance of severe symptoms because of the patient’s size and anticoagulation requirements and the possible need for early reoperation. The purpose of this study was to determine long-term ventricular function after mitral valve surgery in symptomatic children and to analyze risk factors for adverse outcome. Methods and Results Thirty-three patients (0.5 to 19 years old) operated on for mitral regurgitation as a single hemodynamically significant lesion were studied. All but 3 had medically refractory symptoms. One patient died during surgery, and 32 were followed for 0.3 to 17.1 years (mean, 4.5 years). The mean preoperative left ventricular shortening fraction was 0.38±0.09. Successful mitral valvuloplasty or replacement was documented by long-term normalization of end-diastolic dimensions. Early postoperative shortening fraction was significantly reduced (0.28±0.1, P &lt;.01), but it improved to 0.40±0.07 ( P &lt;.01) on late follow-up, at which time only 1 patient had ventricular dysfunction. Preoperative shortening fractions did not correlate well with early or late postoperative values ( r =.18 and r =.31, respectively). Seven of 32 surviving patients had preoperative shortening fractions &lt;0.33 (mean, 0.26±0.05) and 25 &gt;0.33 (mean, 0.39±0.08). Analysis of these subgroups showed no significant differences between the groups in early or late postoperative function. Duration of mitral insufficiency appeared to be associated with the development of atrial arrhythmias. Conclusions Late left ventricular function normalizes in children after surgical correction of mitral insufficiency. In contrast to adults, delay of surgery in children with significant mitral regurgitation until the onset of severe symptoms does not increase the risk for long-term ventricular dysfunction, although late atrial arrhythmias are more likely to be encountered.
THE EFFECT OF HETEROLOGOUS ANTI-LYMPHOCYTE SERUM ON MOUSE HEMOPOIETIC STEM CELLS
Authors: Tom R. DeMeester, Norman D. Anderson, Charles F. Shaffer
Journal: The Journal of Experimental Medicine (1968)

The present study has demonstrated that rabbit anti-mouse lymphocyte serum (RAMLS) has the capability of destroying bone marrow cells and suppressing hemopoietic stem cell function. The in vitro incubation of bone marrow suspensions with RAMLS caused extensive cell lysis with an apparent preferential destruction of lymphoid, erythroid, and blastoid elements. Using the spleen colony assay, the number of functional hemopoietic stem cells was found to be markedly reduced in bone marrow populations exposed to RAMLS in vitro. Further, this loss of stem cell function could be produced by exposing marrow suspensions to small concentrations of antiserum which did not produce detectable cytotoxic effects on the general marrow population. A similar effect of RAMLS upon hemopoietic stem cells was found in vivo. The intravenous injection of RAMLS into lethally irradiated mice immediately after the infusion of isogeneic marrow cells reduced the number of spleen colonies formed, indicating that the antiserum could exhibit a deleterious effect upon stem cells in the bloodstream of the intact animal. Normal animals treated with daily subcutaneous injections of RAMLS for 3 wk had a significantly reduced marrow content of functional hemopoietic stem cells, suggesting that RAMLS can affect stem cells located in situ in the bone marrow. The experiments indicate that RAMLS possesses potential marrow toxicity.
Abstract 2319: Dynamics of TET methylcytosine dioxygenases in 5-methylcytosine and 5-hydroxymethylcytosine patterning in human cancer cells
Authors: Emily L. Putiri, Rochelle L. Tiedemann, Jeong-Hyeon Choi, Keith D. Robertson
Journal: Cancer Research (2014)

Abstract The Ten-eleven translocation (TET) family of dioxygenases hydroxylate 5-methylcytosine (5mC) to 5-hydroxymethylcytosine (5hmC) in DNA. 5mC provides important epigenetic instructions during development, and its aberrant control is a major contributor to cellular transformation; however TET functions in regulating the epigenome, particularly in cancer, remain largely unknown. We targeted TET1, TET2, and TET3 for siRNA-mediated depletion in pluripotent human embryonic carcinoma cells and examined the impact on 5mC and 5hmC genome-wide localization. TET1, TET2, and TET3 co-regulate 5hmC at many sites, and depletion of only one of the TETs is sufficient to reduce 5hmC at these co-regulated sites, suggesting a functional co-dependence for TETs. Depletion of TET1 and TET2 had the greatest impact on 5hmC levels at high and low CpG density promoters, respectively, indicating that TETs exhibit DNA sequence-based functional specificity. All TETs prevent hypermethylation throughout the genome, especially in CpG island shores, where TET depletion resulted in prolific hypermethylation. Promoter hypermethylation resulting from TET depletion was associated with histone H2AK119 monoubiquitination, DNMT1, and DNMT3B occupancy. Surprisingly, TETs also promote cytosine methylation, as many loci became hypomethylated following TET depletion. Induction of differentiation generally caused 5hmC reduction, except at transcriptionally activated genes, which become enriched for 5hmC. Importantly, genes prone to promoter hypermethylation in cancer become depleted of intragenic 5hmC and 5mC with TET deficiency. This study highlights the multi-dimensional functions of TETs in mediating DNA methylation, hydroxymethylation, and gene expression patterns, and the results reveal that chromatin landscape and DNA sequence composition are regulators of TET function. Citation Format: Emily L. Putiri, Rochelle L. Tiedemann, Jeong-Hyeon Choi, Keith D. Robertson. Dynamics of TET methylcytosine dioxygenases in 5-methylcytosine and 5-hydroxymethylcytosine patterning in human cancer cells. [abstract]. In: Proceedings of the 105th Annual Meeting of the American Association for Cancer Research; 2014 Apr 5-9; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2014;74(19 Suppl):Abstract nr 2319. doi:10.1158/1538-7445.AM2014-2319
Prevention of Cardiac Allograft Arteriosclerosis by Protein Tyrosine Kinase Inhibitor Selective for Platelet-Derived Growth Factor Receptor
Authors: Roope Sihvola, Petri Koskinen, Marjukka Myllärniemi, Michael Loubtchenkov, Pekka Häyry, Elisabeth Buchdunger, Karl Lemström
Journal: Circulation (1999)

Background —Increased immunoreactivity of platelet-derived growth factor (PDGF)-AA, -Rα, and -Rβ in intimal cells correlates with the development of cardiac allograft arteriosclerosis, a condition for which there is little or no current therapy. Therefore, we hypothesized that PDGF may have a rate-limiting role in the development of this disease. Methods and Results —The hypothesis was tested in a rat model of heterotopic cardiac and aortic allografts using dark agouti (AG-B4, RT1 a ) donors and Wistar-Furth (AG-B2, RT1 u ) recipients. The recipients received CGP 53716, a selective PDGF-R protein tyrosine kinase inhibitor, 50 mg · kg −1 · d −1 , or vehicle for 60 days. Cardiac allograft recipients also received background cyclosporin A immunosuppression. Our results demonstrate that CGP 53716 significantly reduced the incidence and intensity of arteriosclerotic lesions in rat cardiac and aortic allograft recipients. When rat coronary smooth muscle cells were stimulated in vitro with PDGF-AA or -BB in the presence of interleukin-1β or tumor necrosis factor-α, CGP 53716 significantly inhibited only AA-ligand–induced but not BB-ligand–induced replication. Concomitantly, in quantitative reverse transcriptase–polymerase chain reaction, interleukin-1β or tumor necrosis factor-α stimulation specifically upregulated the expression of PDGF-Rα mRNA but not of other ligand or receptor genes in cultured smooth muscle cells. Conclusions —We conclude that a PDGF-AA/Rα–dependent cycle is induced in the generation of allograft arteriosclerosis that may be inhibited by blocking of signaling downstream of PDGF-R.
Effect of Glipizide on Insulin Secretion and Insulin Metabolism in Obese Type II Diabetic Patient
Authors: Enzo Bonora, Franco Pisani, Rocco Micciolo, Angela Corgnati, Michele Muggeo
Journal: Diabetes Care (1987)

this study was designed to explore the short-term effect of glipizide on insulin secretion and metabolism. Plasma insulin and C-peptide levels in the fasting state and after a 100-g oral glucose load were measured in 17 obese newly diagnosed type II (non-insulin-dependent) diabetic subjects before and after 1 mo of treatment with glipizide (15 mg/day). Plasma glucose levels decreased significantly after treatment with glipizide. Plasma insulin and C-peptide concentrations in the fasting state did not change after glipizide treatment. Also, postglucose plasma insulin levels did not change after glipizide, whereas postglucose plasma C-peptide concentrations significantly increased. A significant relationship was found between the increase in C-peptide plasma levels and the decrease in glycemic profile after glucose load following glipizide treatment. The relation between plasma C-peptide and insulin incremental areas after the oral glucose load significantly increased after treatment. These results suggest that in obese type II diabetic patients, 1 mo of treatment with glipizide potentiates the (β-cell response to oral glucose load and increases insulin metabolism, probably within the liver.
Decision on out of hours package endorsed GPs will plan the contract for the future Health secretary spells out future for family doctors Registrars may withdraw from summative assessments Correction
Authors: L. Beecham
Journal: BMJ (1995)

# Decision on out of hours package endorsed {#article-title-2}

One month after the General Medical Services Committee took its unanimous decision to accept the government's revised proposals on out of hours without balloting the profession (30 September, pp 827-8) the committee has resolved overwhelmingly to stand by its decision. The meeting failed tosupport a request from the chairman of the Birmingham Local Medical Committee, Dr Fay Wilson, forstanding orders to be suspended so that the GMSC could reconsider its decision not to ballot on the package. The committee did, however, recognise the “widespread concern” on the matter and agreed to communicate with the profession the reasons for taking the decision.

Speakers at last week's meeting reported disquiet at some LMC meetings that a ballot had not been arranged; some of the disquiet they accepted had been fuelled by misleading articles in the press. Other committees had endorsed the GMSC's decision unreservedly and did not want the debate to be reopened. When committee members had reported the debate at the September meeting much of the concern had evaporated, although the secretary of Berkshire and Buckinghamshire LMCs, Dr Eric Rose,who believed that the debate should be reopened, reported that there were many disaffected doctors in his constituencies who were threatening motions of no confidence in the GMSC.

One of the negotiators, Dr Brian Goss, said that most of the discontented doctors fell into twogroups--those who wanted nothing at all to do with out of hours work and those who thought they would lose financially. The committee could do nothing for these groups.

The GMSC will communicate its reasons for not voting for another ballot in briefings to the press and letters to LMCs. …
RELATION OF VOLUNTARY HEALTH AGENCY TO PHYSICIANS AND HEALTH DEPARTMENTS
Authors: LINSLY R. WILLIAMS
Journal: JAMA (1927)

The term "public health" has been somewhat loosely applied to everything which has to do with keeping people well, preventing disease and caring for the sick. Although care of the sick is not considered as a health activity, activities organized for the prevention of disease grow out of the movement for the care of the sick. The care of the sick was carried on by religious orders during the middle ages and later by private organizations, particularly in England. The colonies and the United States followed the English tradition in organizing private hospitals and later dispensaries for the care of the sick. There were relatively few efforts made by governmental authority in this country for the care of the sick until the middle of the last century. Health departments were organized primarily for the suppression of epidemics; and as the knowledge of disease became more definite, their efforts were also
The mitochondrial origin of postischemic arrhythmias
Authors: Fadi G. Akar, Miguel A. Aon, Gordon F. Tomaselli, Brian O’Rourke
Journal: Journal of Clinical Investigation (2005)

Recovery of the mitochondrial inner membrane potential (ΔΨm) is a key determinant of postischemic functional recovery of the heart. Mitochondrial ROS-induced ROS release causes the collapse of ΔΨm and the destabilization of the action potential (AP) through a mechanism involving a mitochondrial inner membrane anion channel (IMAC) modulated by the mitochondrial benzodiazepine receptor (mBzR). Here, we test the hypothesis that this mechanism contributes to spatiotemporal heterogeneity of ΔΨm during ischemia-reperfusion (IR), thereby promoting abnormal electrical activation and arrhythmias in the whole heart. High-resolution optical AP mapping was performed in perfused guinea pig hearts subjected to 30 minutes of global ischemia followed by reperfusion. Typical electrophysiological responses, including progressive AP shortening followed by membrane inexcitablity in ischemia and ventricular fibrillation upon reperfusion, were observed in control hearts. These responses were reduced or eliminated by treatment with the mBzR antagonist 4′-chlorodiazepam (4′-Cl-DZP), which blocks depolarization of ΔΨm. When applied throughout the IR protocol, 4′-Cl-DZP blunted AP shortening and prevented reperfusion arrhythmias. Inhibition of ventricular fibrillation was also achieved by bolus infusion of 4′-Cl-DZP just before reperfusion. Conversely, treatment with an agonist of the mBzR that promotes ΔΨm depolarization exacerbated IR-induced electrophysiological changes and failed to prevent arrhythmias. The effects of these compounds were consistent with their actions on IMAC and ΔΨm. These findings directly link instability of ΔΨm to the heterogeneous electrophysiological substrate of the postischemic heart and highlight the mitochondrial membrane as a new therapeutic target for arrhythmia prevention in ischemic heart disease.
Australia’s healthcare reform body is criticised for its narrow membership
Authors: Melissa Sweet
Journal: BMJ (2008)

The government has agreed in principle that the General Medical Council, the medical profession's regulator, will take over responsibility for postgraduate medical training in the United Kingdom.The move to assimilate the Postgraduate Medical and Training Board within the GMC-which will not go ahead before 2010-has been welcomed by Graeme Catto, the council's president.Sir Graeme said, "The merger will bring under one roof the regulation of all stages of medical education and will deliver real benefits for patients and the public, as well as for the medical profession."He added that the board, which was set up in autumn 2005, had made an important contribution to postgraduate medical education in the UK and promised to maintain the momentum it had generated.However, in a statement the Royal College of Surgeons of England expressed its disappointment at the slow timetable for implementing the change."We are pleased with the acceptance that PMETB [the Postgraduate Medical Education and Training Board] will become part of the GMC.However, it is disappointing that no opportunity can apparently be found to carry out this badly needed reform until 2010," it said.Altogether the government agreed (or agreed in principle) to 24 of 47 recommendations made by John Tooke in the report of his inquiry into the reform of Modernising Medical Careers (MMC), which was published in January (BMJ 2008;336:61, 12 Jan).Other proposals were put on hold for "further consideration" or were dismissed as the responsibility of other organisations.Proposals that were agreed in principle are to be evaluated as part of the next stage review, being carried out by health minister Lord Darzi and due to be published in June.Alan Johnson, the health secretary, said that his department needed more time to consider one of the late additions to the list of recommendations, the proposal to set up a new independent body, provisionally called NHS Medical Education England, GMC will take responsibility for postgraduate medical training, as advised by Tooke report UK NEWS Deaths from cancer fall after 20 years of screening in England, p 527 WorlD NEWS European Commission looks into possible restrictive practices by drug companies, p 524 bmj.com london GPs express fear over Darzi's proposals for the capital
Inhibition of the SDF-1/CXCR4 Axis Attenuates Neonatal Hypoxia-Induced Pulmonary Hypertension
Authors: Karen C. Young, Eneida Torres, Konstantinos E. Hatzistergos, Dorothy Hehre, Cleide Suguihara, Joshua M. Hare
Journal: Circulation Research (2009)

Exposure of the neonatal lung to chronic hypoxia produces significant pulmonary vascular remodeling, right ventricular hypertrophy, and decreased lung alveolarization. Given recent data suggesting that stem cells could contribute to pulmonary vascular remodeling and right ventricular hypertrophy, we tested the hypothesis that blockade of SDF-1 (stromal cell–derived factor 1), a key stem cell mobilizer or its receptor, CXCR4 (CXC chemokine receptor 4), would attenuate and reverse hypoxia-induced cardiopulmonary remodeling in newborn mice. Neonatal mice exposed to normoxia or hypoxia were randomly assigned to receive daily intraperitoneal injections of normal saline, AMD3100, or anti–SDF-1 antibody from postnatal day 1 to 7 (preventive strategy) or postnatal day 7 to 14 (therapeutic strategy). As compared to normal saline, inhibition of the SDF-1/CXCR4 axis significantly improved lung alveolarization and decreased pulmonary hypertension, right ventricular hypertrophy, vascular remodeling, vascular cell proliferation, and lung or right ventricular stem cell expressions to near baseline values. We therefore conclude that the SDF-1/CXCR4 axis both prevents and reverses hypoxia-induced cardiopulmonary remodeling in neonatal mice, by decreasing progenitor cell recruitment to the pulmonary vasculature, as well as by decreasing pulmonary vascular cell proliferation. These data offer novel insights into the role of the SDF-1/CXCR4 axis in the pathogenesis of neonatal hypoxia-induced cardiopulmonary remodeling and have important therapeutic implications.
GASTROENTEROSTOMY FOR CARCINOMA OF PYLORUS.
Authors: J. HENRY BARBAT
Journal: JAMA (1900)

The following case is reported to show the benefit of making a gastroenterostomy in cases of inoperable carcinoma of the pylorus, where the disease has advanced so far that the patient is starving to death on account of vomiting due to occlusion of the pyloric orifice. Mrs. F., aged 45 years, the mother of four children, had enjoyed perfect health until two years ago, when she began to vomit after eating and felt slight pains in her stomach. This kept on increasing, and the patient began to lose flesh, until when I saw her, February 28, she weighed but 90 pounds. I found a mass in the region of the pylorus, about as large as a hen's egg, and advised immediate operation, explaining that I might be able to remove the entire area of disease, and if not, I would at least make an opening to allow the food to
How to Operationalize Alexithymic Phenomena – Some Findings from Speech Analysis and the Giessen Test (GT)
Authors: G. Overbeck
Journal: Psychotherapy and Psychosomatics (1977)

Other Types| February 16 2010 How to Operationalize Alexithymic Phenomena – Some Findings from Speech Analysis and the Giessen Test (GT) / Discussion Subject Area: Psychiatry and Psychology G. Overbeck G. Overbeck Frankfurt/Main Search for other works by this author on: This Site PubMed Google Scholar Psychother Psychosom (1977) 28 (1-4): 106–120. https://doi.org/10.1159/000287051 Article history Published Online: February 16 2010 Content Tools Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Facebook Twitter LinkedIn Email Tools Icon Tools Get Permissions Cite Icon Cite Search Site Citation G. Overbeck; How to Operationalize Alexithymic Phenomena – Some Findings from Speech Analysis and the Giessen Test (GT) / Discussion. Psychother Psychosom 31 December 1977; 28 (1-4): 106–120. https://doi.org/10.1159/000287051 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAll JournalsPsychotherapy and Psychosomatics Search Advanced Search Article PDF first page preview Close Modal This content is only available via PDF. 1977Copyright / Drug Dosage / DisclaimerCopyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher.Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. You do not currently have access to this content.