Glucagon Provocative Test for Pheochromocytoma
Authors: A. M. LAWRENCE
Journal: Annals of Internal Medicine (1967)

Article1 June 1967Glucagon Provocative Test for PheochromocytomaA. M. LAWRENCE, M.D., PH.D.A. M. LAWRENCE, M.D., PH.D.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-66-6-1091 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptAlthough diagnosing pheochromocytoma has been greatly assisted by recent advances for the chemical determination of urinary pressor amines, the paroxysmally secreting form may, nevertheless, offer formidable obstacles to early diagnosis. To this end the pharmacologic provocative tests can still prove indispensable. Histamine is probably the most familiar agent used for this purpose (1). Recently, Engelman and Sjoerdsma (2) described a differing pressor response to titrated doses of tyramine useful in distinguishing pheochromocytomas from other forms of hypertension. More recently, I reported that glucagon, the hyperglycemic, glycogenolytic peptide secreted by the alpha cells of the islets of Langerhans, evokes striking pressor...References1. ROTHKVALE GMWF: Tentative test for pheochromocytoma. Amer. J. Med. Sci. 210: 653, 1945. CrossrefGoogle Scholar2. ENGELMANSJOERDSMA KA: A new test for pheochromocytoma. Pressor responsiveness to tyramine. JAMA 189: 81, 1964. CrossrefMedlineGoogle Scholar3. LAWRENCE AM: A new provocative test for pheochromocytoma (abstract). Ann. Intern. Med. 63: 905, 1965. LinkGoogle Scholar4. HELMER OM: Estimation of urinary catechol amines by means of a strip of rabbit aorta as an aid in the diagnosis of pheochromocytoma. J. Lab. Clin. Med. 50: 737, 1957. MedlineGoogle Scholar5. EULERLISHAJKO USF: Improved technique for the fluorometric estimation of catecholamines. Acta Physiol. Scand. 51: 348, 1961. CrossrefMedlineGoogle Scholar6. ENGELMAN K: Personal communication. Google Scholar7. MONTALBANOBARONOFSKYBALL FPIDH: Hyperplasia of the adrenal medulla. A clinical entity. JAMA 182: 264, 1962. CrossrefGoogle Scholar8. GOLDFIENZILELIDESPOINTESBETHUNE AMSRHJE: The effect of hypoglycemia on the adrenal secretion of epinephrine and norepinephrine in the dog. Endocrinology 62: 739, 1958. CrossrefGoogle Scholar9. UNGEREISENTRAUTMCCALLMADISON RHAMMSLL: Measurements of endogenous glucagon in plasma and the influence of blood glucose concentration upon its secretion. J. Clin. Invest. 41: 682, 1962. CrossrefMedlineGoogle Scholar10. SCIANWESTERMANNVERDESCAHILTON LFCDASJG: Adrenocortical and medullary effects of glucagon. Amer. J. Physiol. 99: 867, 1960. CrossrefGoogle Scholar11. SARCIONEBACKSOKALMEHLMANKNOBLOCK EJNJEBE: Elevation of plasma epinephrine levels produced by glucagon in vivo. Endocrinology 72: 523, 1963. CrossrefMedlineGoogle Scholar12. LEFEBVRECESSION-FOSSIONLUYCKX PJAAS: Glucagon test for pheochromocytoma. Lancet 2: 1366, 1966. CrossrefGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Chicago, IllinoisFrom the Department of Medicine, The University of Chicago, Chicago, Ill.This study was supported by the Fisher Endocrine Research Fund, The University of Chicago Medical School, and by grants FR-55 and T1-AM-5107, U. S. Public Health Service, Washington, D. C.At the time of this investigation Dr. Lawrence was an American College of Physicians Teaching and Research Scholar.This work was presented at the Third Fall Meeting of the American College of Physicians, Miami Beach, Fla., October 1965.Requests for reprints should be addressed to A. M. Lawrence, M.D., Department of Medicine, The University of Chicago, 950 E. 59th St., Chicago, Ill. 60637. 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