tbuckley/cabot-search huggingface dataset:
Redox-sensitive micelles self-assembled from amphiphilic hyaluronic acid-deoxycholic acid conjugates for targeted intracellular delivery of paclitaxel
Authors: Jing Li, Meirong Huo, Jing Wang, Jianping Zhou, Jumah M. Mohammad, Yinlong Zhang, Qinnv Zhu, Ayman Y. Waddad, Qiang Zhang
Journal: Biomaterials (2011)
Improvement of quality of life by treatment with cetirizine in patients with perennial allergic rhinitis as determined by a French version of the SF-36 questionnaire
Authors: J. Bousquet, J. Duchateau, J.C. Pignat, C. Fayol, P. Marquis, S. Mariz, J.E. Ware, B. Valentin, B. Burtin
Journal: Journal of Allergy and Clinical Immunology (1996)
Detection of Coronary Artery Stenoses by Low-Dose, Prospectively ECG-Triggered, High-Pitch Spiral Coronary CT Angiography
Authors: Stephan Achenbach, Tobias Goroll, Martin Seltmann, Tobias Pflederer, Katharina Anders, Dieter Ropers, Werner G. Daniel, Michael Uder, Michael Lell, Mohamed Marwan
Journal: JACC. Cardiovascular imaging (2011)
A randomized comparison of crystalloid and blood-containing cardioplegic solutions in 60 patients.
Authors: E E Buttner, R B Karp, J G Reves, S Oparil, C Brummett, H G McDaniel, L R Smith, G Kreusch
Journal: Circulation (1984)

To determine whether adding blood to a cardioplegic solution affects myocardial preservation, a randomized prospective study was carried out in 60 patients undergoing coronary revascularization to compare the effects of crystalloid potassium cardioplegics (group C) and potassium cardioplegic solutions to which blood has been added (group B) on markers of myocardial metabolism (lactate, inorganic phosphate, base deficit release, glucose and lactate uptake, oxygen extraction), myocardial damage (creatine kinase [CK]-MB levels), and cardiac performance (cardiac index and left atrial pressure). The solution with added blood had a significantly (p less than .05) greater oxygen content, a lower pH, and higher concentrations of potassium, calcium, sodium, and glucose. In group B patients there was a suggestion (p less than .06) of greater uptake of oxygen during the beginning of the initial cardioplegic infusion. During reperfusion there was no evidence of differential release of the metabolites of anaerobiosis and myocardial oxygen extraction and glucose and lactate uptake were similarly depressed in both groups. Likewise, CK-MB release after bypass was the same in both groups. Prompt, adequate functional recovery of cardiac index and left atrial pressure was observed in both groups. It was concluded that although there may be more oxygen available from the blood-containing solution during early infusion, there is no evidence that under the conditions of this investigation adding blood to cardioplegic solution improves myocardial preservation.
Mouse Mammary Tumor Virus Infects Human Cells
Authors: Stanislav Indik, Walter H. Günzburg, Brian Salmons, Francoise Rouault
Journal: Cancer Research (2005)

Mouse mammary tumor virus (MMTV) has long been speculated to be involved in human breast cancer and more recently in human primary biliary cirrhosis. Despite complete proviral sequences markedly homologous to MMTV being identified in human breast cancer tissue, no convincing evidence has been presented to date that MMTV can infect human cells. Using both wild-type and a genetically marked virus (MMTV-EGFP), we show here the successful infection of a number of different human cells by MMTV. Furthermore, infection of human cells is shown to be almost as efficient as the infection of murine mammary epithelial cells. Sequencing of PCR products from integrated proviruses reveals that reverse transcription and integration of the viral genome has occurred as expected. Furthermore, sequencing of two independent MMTV proviral integration sites reveal them to be present only in the human and not in the mouse genome. Infection requires an intact MMTV envelope protein and is blocked either by heat inactivation of the virus or by specific neutralizing anti-MMTV serum, ruling out a nonspecific mechanism of viral transfer. Thus, MMTV can infect human cells and this finding provides a possible explanation for the detection by others of MMTV sequences in human breast cancer patients.
Cell cycle distribution defect in PHA‐stimulated T lymphocytes of sickle cell disease patients
Authors: J. M. Abdallah, Mark Kukuruga, Alexander Nakeff, Ananda S. Prasad
Journal: American Journal of Hematology (1988)

Abstract T lymphocytes from normal human controls and sickie cell disease (SCD) patients were isolated from peripheral blood and cultured for 72 hours following addition of phytohem‐agglutinin. The ratio for the fraction of cells in DNA synthesis (S phase) over the fraction in G2 phase (S/G2) was significantly higher in SCD patients in comparison to the controls (mean ± SD) (4.01 ± 0.78 vs. 2.78 ± 0.76, P &lt; 0.02). Following in vivo zinc supplementation to two subjects, the S/G2 ratio was normalized. We conclude that the distribution of T lymphocytes in cell cycle is altered in SCD patients and that this effect may be zinc‐de‐pendent.
Auto Driver Fitness: An Evaluation of Useful Criteria
Authors: John L. Benton
Journal: JAMA (1961)

In order to assess factors that might affect the fitness of automobile drivers, the drivers of an amateur sports car racing club were studied. Physical, psychological, ophthalmological, and reaction-time testing was carried out and compared with drivers' records of deportment during races and accidents. Of the 4 types of procedure used in this study, psychological testing had the most value in differentiating between safe and unsafe drivers.
Dietary Fiber—An Overview
Authors: James W Anderson, Abayoml O Akanji
Journal: Diabetes Care (1991)

Diabetes diets should aim at ensuring an ideal body weight with normoglycemia and normolipidemia. The consensus recommendations of various diabetes associations suggest that these goals are most likely to be achieved by diets high in complex carbohydrates and fiber and low in fat. A typical diabetes diet containing 55–60% energy as carbohydrate (at least 66% complex), &amp;lt;30% energy as fat, 0.8 g.kg−1 desirable body wt.day−1 protein, and ∼40 g fiber/day, improves glycemic control, reduces levels of serum atherogenic lipids, decreases blood pressure in those with hypertension, and reduces body weight in the obese. This diet also reduces insulin requirements in the insulin-treated patient and can promote discontinuation of insulin therapy in those with non-insulin-dependent diabetes mellitus. This article presents our experience with high-fiber high-carbohydrate diets and reviews knowledge on the likely mechanisms of action of fiber, its long-term effectiveness, and the concerns about its long-term safety. We suggest that reports on the risk of hypertriglyceridemia from on the risk of hypertriglyceridemia from high-carbohydrate diets are inconsistent and invalidated if those diets are also high in fiber content. Similarly, we urge some caution in prescribing high-monounsaturated fat diets as an alternative to high-carbohydrate diets, at least until the long-term implications of the former are clearer. We believe that there is no compelling reason to change the current diabetes diets, which should continue to be high in carbohydrate and fiber content.
Immunoglobulin‐G‐dependent stimulation of guinea pig lung mast cells and macrophages
Authors: M. Al‐Laith*, A. Weyer, N. Havet, C. Dumarey, B. B. Vargaftig, M. Bachelet
Journal: Allergy (1993)

Alveolar macrophages and mast cells isolated from guinea pig lung were passively sensitized with IgG1, IgG2, or serum obtained from guinea pigs actively sensitized with ovalbumin. The release of histamine by mast cells and of thromboxane A2 by alveolar macrophages upon ovalbumin challenge indicated that both antibodies and serum were capable of sensitizing these cells with similar effectiveness. Heating the scrum at 56°C for 4 h to inactivate IgE did not modify the antigen‐dependent response of lung cells. These results suggest a predominant role for IgG in the allergic response of the guinea pig through the activation of different cell types such as lung mast cells and alveolar macrophages.
Erratum: Corrigendum: Immunological synapse formation inhibits, via NF-κB and FOXO1, the apoptosis of dendritic cells
Authors: Lorena Riol-Blanco, Cristina Delgado-Martín, Noelia Sánchez-Sánchez, Luis M Alonso-C, María Dolores Gutiérrez-López, Gloria Martínez del Hoyo, Joaquín Navarro, Francisco Sánchez-Madrid, Carlos Cabañas, Paloma Sánchez-Mateos, José Luis Rodríguez-Fernández
Journal: Nature Immunology (2010)
Transvaginal compared with transvesical ultrasonography for recovery of oocytes for in vitro fertilisation
Authors: D. Barlow, P. Bromwich, M. Wiley, A. Walker, C. Ross, S. Kennedy, A. Lopez-Bernal
Journal: BMJ (1988)

Transvaginal compared with transvesical ultrasonography for recovery of oocytes for in vitro fertilisation Oocyte recovery guided by transvaginal ultrasonography has been introduced into in vitro fertilisation units and compares favourably with laparoscopic oocyte recovery. 2The transition from laparoscopy to ultrasonography may, however, account for part of this difference-for example, anaesthetic requirements and risks of pneumoperitoneum are reduced.In Oxford the in vitro fertilisation unit is an outpatient service and used transvesical ultrasonography3 until transvaginal scanning was introduced.Thus we were able to make a direct assessment of the value of oocyte recovery by transvaginal scanning.
Interaction of IGF-I and 1α,25(OH)2D3 on receptor expression and growth stimulation in rat growth plate chondrocytes
Authors: Günter Klaus, Lutz Weber, Julian Rodríguez, Porfirio Fernández, Thomas Klein, J. Grulich-Henn, Ulrike Hügel, Eberhard Ritz, Otto Mehls
Journal: Kidney International (1998)
The Standard of Care: A Case Report and Ethical Analysis
Authors: JOHN LA PUMA
Journal: Annals of Internal Medicine (1988)

Physicians increasingly allow their perceived legal responsibilities to displace their clinical judgment. Misunderstandings that surround the term "standard of care" have encouraged fears of liability and have led to the practice of defensive medicine. Physicians may consider the standard of care to be a technical or legal obligation, but an optimal standard would be one based on detailed knowledge of a patient's medical history and personal condition. It would include the physician's clinical judgment, which integrates specific technical and legal information with clinical experience in caring for patients. Occasionally, such judgment may conflict with the rulings of a court, which considers technical and legal information without the benefit of clinical judgment. Physicians must be prepared to be advocates for their patients, especially when legal proceedings are flawed or injurious. Systematic processes of examination and analysis, such as those used by ethics consultants, can help resolve questions about the standard of care.
Production of cartilage degrading activity by human synovial tissues.
Authors: M F Brown, B L Hazleman, J T Dingle, D J Dandy, A H Murley
Journal: Annals of the Rheumatic Diseases (1987)

Human synovial tissues have been assayed for the production of cartilage degrading activity (CDA). This activity is thought to be homologous with catabolin/interleukin 1 (IL1) produced by porcine synovium and leucocytes and by human leucocytes. The CDA of 26 rheumatoid (RA) and 41 non-rheumatoid synovia was measured on a dry weight basis. The rheumatoid synovia showed a threefold increase in activity over the non-rheumatoid, but there was no significant overall difference on a deoxyribonucleic acid (DNA) basis. The rheumatoid synovia appeared to consist of two populations; in over half the samples CDA was not related to cellularity, but eight patients had a high CDA and a high cellularity.
Job sharing at a children's hospital: evaluation by medical staff
Authors: J. P Valentine, C. J Martin
Journal: BMJ (1996)

<h3>Abstract</h3> <b>Objective</b>: To evaluate job sharing for registrars at Princess Margaret Hospital for Children, Perth, by seeking responses from members of the relevant medical teams. <b>Design</b>: A questionnaire was sent to all 126 medical staff within the hospital (and three managers in medical administration) asking their views on job sharing for registrars. <b>Outcome measures</b>: Whether job sharing should continue, who should do it, at what stage of training, and the effects on patient care. <b>Results</b>: Among the 77 respondents (60%) there was broad support for the continuation of job sharing at the hospital: only 5 of 37 consultants and 2 of 19 non-job sharing registrars rejected the idea (with a further 4 consultants uncertain). 43% Of the consultants who had worked with job sharing registrars thought continuity of care was adversely affected. <b>Conclusion</b>: The committee for physician training of the Royal Australasian College of Physicians emphasises that advanced training should be flexible, with a wide range of opportunities for individuals to plan an appropriate training programme in line with their personal goals. This study has shown that job sharing for registrars at Princess Margaret Hospital for Children allows this choice. Action on concerns over any adverse effects on patient care should resolve any persisting disquiet.
604 MONOCYTE-DERIVED DENDRITIC CELLS FROM HCV PATIENTS TRANSDUCED WITH A RECOMBINANT ADENOVIRUS EXPRESSING NS3 RETAIN THEIR FUNCTIONAL PROPERTIES WHEN STIMULATED WITH THE TLR3 LIGAND POLY(I:C)
Authors: I. Echeverria, A. Zabaleta, L. Silva, N. Diaz-Valdes, J.I. Riezu-Boj, J.J. Lasarte, F. Borras-Cuesta, M.P. Civeira, J. Prieto, P. Sarobe
Journal: Journal of Hepatology (2008)
The Direct Effects of Norepinephrine, Epinephrine, and Methoxamine on Myocardial Contractile Force in Man
Authors: LEON I. GOLDBERG, ROBERT D. BLOODWELL, EUGENE BRAUNWALD, ANDREW G. MORROW
Journal: Circulation (1960)

The effects of 5 sympathomimetic amines on myocardial contractile force were determined with the Walton-Brodie strain-gage arch in 16 patients undergoing operations for congenital heart disease. Equal doses of norepinephrine and epinephrine produced almost identical increments in myocardial contractile force; equipressor doses of methoxamine resulted in little or no change in the force of contraction. Mephentermine and metaraminol produced increments in myocardial contractile force similar to those following norepinephrine administration but the duration of action was longer. The results of these studies indicate that there are no qualitative differences in the actions of these amines on cardiac contractile force of dog and man and provide a basis for the rational clinical use of these agents.
Epidemic of Aseptic Peritonitis Caused by Endotoxin during Chronic Peritoneal Dialysis
Authors: S. Karanicolas, D.G. Oreopoulos, Sh. Izatt, A. Shimizu, R.F. Manning, H. Sepp, G.A. deVeber, T. Darby
Journal: New England Journal of Medicine (1977)

Of all episodes of peritonitis among patients undergoing chronic peritoneal dialysis 15 to 30 per cent1,2 are described as aseptic — that is, all symptoms and signs of peritonitis are present, but cultures of the effluent are negative. No responsible agent has been identified to date.An epidemic of 48 episodes of aseptic peritonitis occurred during a four-week period among 28 patients maintained on chronic peritoneal dialysis in two hospitals. Dialysate in 2-liter plastic containers was used in all cases.Diffuse abdominal pain and rebound tenderness were the predominant findings, occurring on an average of seven hours after initiation of . . .
Osteogenic Sarcoma
Authors: Kenneth C. Francis, Robert V. P. Hutter, Ralph K. Phillips, Robert C. Eyerly, Lawrence Schechter
Journal: New England Journal of Medicine (1962)

THE remission of cancer after dissemination is so rare that such cases should be documented and recorded. The patient described below has no clinical or radiographic evidence of cancer five years after the diagnosis of pulmonary metastases from an osteogenic sarcoma of the femur.Case ReportP.D., an 8-year-old boy, was admitted to Memorial Hospital on December 14, 1955, with a history of pain in the left thigh of 3 months' duration and a mass in the left thigh of 1 month's duration. Physical examination on admission revealed a boy in some discomfort. The distal portion of the left thigh . . .
Peter Julius Denison Heaf
Authors: S. Spiro
Journal: BMJ (2010)

<h3>ABSTRACT</h3> Identifying genomic annotations that differentiate causal from associated variants is critical to fine-map disease loci. While many studies have identified non-coding annotations overlapping disease variants, these annotations colocalize, complicating fine-mapping efforts. We demonstrate that conventional enrichment tests are inflated and cannot distinguish causal effects from colocalizing annotations. We developed a sensitive and specific statistical approach that is able to identify independent effects from colocalizing annotations. We first confirm that gene regulatory variants map to DNase-I hypersensitive sites (DHS) near transcription start sites. We then show that (1) 15-35% of causal variants within disease loci map to DHS independent of other annotations; (2) breast cancer and rheumatoid arthritis loci harbor potentially causal variants near the summits of histone marks rather than full peak bodies; and (3) variants associated with height are highly enriched for embryonic stem cell DHS sites. We highlight specific loci where we can most effectively prioritize causal variation.
Clinical Usefulness of Very High and Very Low Levels of C-Reactive Protein Across the Full Range of Framingham Risk Scores
Authors: Paul M Ridker, Nancy Cook
Journal: Circulation (2004)

Background— High-sensitivity C-reactive protein (hsCRP) is a strong independent risk factor for cardiovascular events, and levels of hsCRP of &lt;1, 1 to &lt;3, and ≥3 mg/L have been suggested to define low-, moderate-, and high-risk groups. However, the positive predictive value of very low (&lt;0.5 mg/L) and very high levels of hsCRP (&gt;10.0 mg/L) is uncertain. Methods and Results— Baseline levels of hsCRP were evaluated among 27 939 apparently healthy women who were followed up for myocardial infarction, stroke, coronary revascularization, or cardiovascular death. Crude and Framingham Risk Score (FRS)–adjusted relative risks (RRs) of incident cardiovascular events were calculated across a full range of hsCRP levels. Cardiovascular risks increased linearly from the very lowest (referent) to the very highest levels of hsCRP. Crude RRs for those with baseline hsCRP levels of &lt;0.5, 0.5 to &lt;1.0, 1.0 to &lt;2.0, 2.0 to &lt;3.0, 3.0 to &lt;4.0, 4.0 to &lt;5.0, 5.0 to &lt;10.0, 10.0 to &lt;20.0, and ≥20.0 mg/L were 1.0, 2.2, 2.5, 3.1, 3.7, 4.2, 4.9, 6.3, and 7.6, respectively ( P for trend &lt;0.001). After adjustment for FRS, these risks were 1.0, 1.6, 1.6, 1.7, 1.9, 2.2, 2.3, 2.8, and 3.1 ( P for trend &lt;0.001). All risk estimates remained significant in analyses stratified by FRS and after control for diabetes. Of the total cohort, 15.1% had hsCRP &lt;0.50 mg/L, and 5.4% had hsCRP &gt;10.0 mg/L. Conclusions— Both very low (&lt;0.5 mg/L) and very high (&gt;10 mg/L) levels of hsCRP provide important prognostic information on cardiovascular risk. hsCRP is clinically useful for risk prediction across a full range of values and across a full range of FRS.
The Effect of Beta-Sitosterol Upon Intestinal Absorption of Cholesterol in the Rat
Authors: MEYER FRIEDMAN, RAY H. ROSENMAN, SANFORD O. BYERS
Journal: Circulation Research (1956)

Thoracic duct lymph was collected from groups of rats fed varying doses of β-sitosterol concomitantly with cholesterol. The results indicated that β-sitosterol exerts only a slightly inhibiting effect upon intestinal absorption of cholesterol in the rat.
The Effects of a Mindfulness-Based Intervention on Emotional Distress, Quality of Life, and HbA1c in Outpatients With Diabetes (DiaMind)
Authors: Jenny van Son, Ivan Nyklíček, Victor J. Pop, Marion C. Blonk, Ronald J. Erdtsieck, Pieter F. Spooren, Arno W. Toorians, François Pouwer
Journal: Diabetes Care (2012)

Emotional distress is common in outpatients with diabetes, affecting ∼20-40% of the patients. The aim of this study was to determine the effectiveness of group therapy with Mindfulness-Based Cognitive Therapy (MBCT), relative to usual care, for patients with diabetes with regard to reducing emotional distress and improving health-related quality of life and glycemic control.In the present randomized controlled trial, 139 outpatients with diabetes (type 1 or type 2) and low levels of emotional well-being were randomized to MBCT (n = 70) or a waiting list group (n = 69). Primary outcomes were perceived stress (Perceived Stress Scale), anxiety and depressive symptoms (Hospital Anxiety and Depression Scale), mood (Profiles of Mood States), and diabetes-specific distress (Problem Areas In Diabetes). Secondary outcomes were health-related quality of life (12-Item Short-Form Health Survey), and glycemic control (HbA(1c)). Assessments were conducted at baseline and at 4 and 8 weeks of follow-up.Compared with control, MBCT was more effective in reducing stress (P < 0.001, Cohen d = 0.70), depressive symptoms (P = 0.006, d = 0.59), and anxiety (P = 0.019, d = 0.44). In addition, MBCT was more effective in improving quality of life (mental: P = 0.003, d = 0.55; physical: P = 0.032, d = 0.40). We found no significant effect on HbA(1c) or diabetes-specific distress, although patients with elevated diabetes distress in the MBCT group tended to show a decrease in diabetes distress (P = 0.07, d = 0.70) compared with the control group.Compared with usual care, MBCT resulted in a reduction of emotional distress and an increase in health-related quality of life in diabetic patients who had lower levels of emotional well-being.
Vemurafenib for Leptomeningeal Melanomatosis
Authors: Niklas Schäfer, Björn Scheffler, Moritz Stuplich, Christina Schaub, Sied Kebir, Claudia Rehkämper, Frederick Mack, Pitt Niehusmann, Matthias Simon, Susanne Greschus, Klaus Kuchelmeister, Ulrich Herrlinger, Martin Glas
Journal: Journal of Clinical Oncology (2013)
The promotion of cardiogenic differentiation of hMSCs by targeting epidermal growth factor receptor using microRNA-133a
Authors: Se-Yeon Lee, Onju Ham, Min-Ji Cha, Byeong-Wook Song, Eunmi Choi, Il-Kwon Kim, Woochul Chang, Soyeon Lim, Chang Youn Lee, Jun-Hee Park, Jiyun Lee, Yoonjin Bae, Hyang-Hee Seo, Eunhyun Choi, Yangsoo Jang, Ki-Chul Hwang
Journal: Biomaterials (2012)
Expert questions whether NHS can be transformed without further upheaval
Authors: N. Hawkes
Journal: BMJ (2015)

Two ideas have taken hold in English health policy, a conference at the health policy think tank the King’s Fund in London was told on 4 February. Unfortunately, they contradict each other.

While there is agreement that the health and social care system needs major reform, there is equally strong agreement that another major reorganisation must at all costs be avoided.

After the trauma of the 2012 Health and Social Care Act no party at the forthcoming general election will be arguing for big legislative changes to the structure of the services. Yet all three main parties agree that substantial change is needed and do not disagree strongly about the direction of change. This paradox was outlined by Chris Ham, chief executive of the King’s Fund. “The last thing we need is another programme of organisational change, but that goes alongside the simultaneous thought that the …