THE PRESSOR REACTION PRODUCED BY INHALATION OF CARBON DIOXIDE; STUDIES OF PATIENTS WITH NORMAL BLOOD PRESSURE AND WITH HYPERTENSION
Authors: Maurice Hardgrove, Grace M. Roth, George E. Brown
Journal: Annals of Internal Medicine (1938)

Article1 October 1938THE PRESSOR REACTION PRODUCED BY INHALATION OF CARBON DIOXIDE; STUDIES OF PATIENTS WITH NORMAL BLOOD PRESSURE AND WITH HYPERTENSIONMAURICE HARDGROVE, M.D., GRACE M. ROTH, PH.D., GEORGE E. BROWN, M.D., F.A.C.P.MAURICE HARDGROVE, M.D., GRACE M. ROTH, PH.D., GEORGE E. BROWN, M.D., F.A.C.P.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-12-4-482 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe specific stimulating action of carbon dioxide on the vasomotor centers and its pressor effect on blood pressure have been known for some time. As early as 1864, Thiry1observed a rise of the blood pressure of animals during the inhalation of carbon dioxide and expressed the opinion that this was the result of stimulation of the vasomotor center, which produces a constriction of the peripheral arterioles. Traube2later confirmed this work and also looked on carbon dioxide as an excitant of the vasomotor center. In contrast to this work, Gaskell3about the same time demonstrated by perfusion experiments that...References1. THIRY L: Ueber das Verhalten der Gefässnerven bei Störungen der Respiration, Centralbl. f. d. med. Wissensch., 1864, ii, 722. Google Scholar2. TRAUBE L: Ueber periodische Thätigkeits—Äusserungen des vasomotorischen- und hemmungs- Nervencentrums, Centralbl. f. d. med. Wissensch., 1865, ii, 881-885. Google Scholar3. GASKELL WH: The involuntary nervous system, 1916, Longmans, Green and Company, London, 178 pp. Google Scholar4. BAYLISS WM: The action of carbon dioxide on blood vessels, Jr. Physiol., 1901, xxvi, xxxii-xxxiii. Google Scholar5. FLEISCH A: Experimentelle Untersuchungen über die Kohlensäurewirkung auf die Blutgefässe, Pflüger's Arch., 1918, clxxi, 86-133. CrossrefGoogle Scholar6. HENDERSON Y: Acapnia and shock. I. Carbon-dioxide as a factor in the regulation of the heart-rate, Am. Jr. Physiol., 1908, xxi, 126-156. CrossrefGoogle Scholar7. DALEEVANS HHCL: Effects on the circulation of changes in the carbon-dioxide content of the blood, Jr. Physiol., 1922, lvi, 125-145. CrossrefGoogle Scholar8. PORTER WT: Shock from fat embolism of the vasomotor center, Am. Jr. Physiol., 1924-1925, lxxi, 277-315. Google Scholar9. SCHNEIDERTRUESDELL ECD: The effects on the circulation and respiration of an increase in the carbon dioxide content of the blood in man, Am. Jr. Physiol., 1922, lxiii, 155-175. CrossrefGoogle Scholar10. RAAB W: Die Beziehungen zwischen CO2-Spannung und Blutdruck bei Normalen und Hypertonikern. Beitrag zur Pathogenese der nicht "nephritischen" Hypertonien, Ztschr. f. d. ges. exper. Med., 1929, lxviii, 337-370. CrossrefGoogle Scholar11. RAAB W: Zur Pathogenese der essentiellen Hypertonie, Klin. Wchnschr., 1929, viii, 1130. CrossrefGoogle Scholar12. ELLISWEISS LBS: The local and systemic effects of arterio-venous fistula on the circulation in man, Am. Heart Jr., 1930, v, 635-647. CrossrefGoogle Scholar13. RAAB W: Functionsprüfung des zentralen Vasomotorenapparates in verschiedenen Lebensaltern, Ztschr. f. klin. Med., 1931, cxviii, 618-629. Google Scholar14. RAAB W: Central vasomotor irritability. Contribution to the problem of essential hypertension, Arch. Int. Med., 1931, xlvii, 727-757. CrossrefGoogle Scholar15. HINESBROWN EAGE: A standard stimulus for measuring vasomotor reactions: its application in the study of hypertension, Proc. Staff Meet. Mayo Clinic, 1932, vii, 332-335. Google Scholar16. BROWN GE: Functional or preclinical stage of essential hypertension, Jr. Tennessee State Med. Assoc., 1933, xxvi, 321-325. Google Scholar17. BOLTONCARMICHAELWILLIAMS BEADJ: Mechanism of peripheral vascular responses to changes in blood gas tension in man, Jr. Physiol., 1936, lxxxviii, 113-126. CrossrefGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Rochester, Minnesota*Received for publication December 3, 1937.†Now residing in Milwaukee, Wisconsin.‡Although Dr. Brown died in November 1935, the fact that he suggested this study and supervised it in its early stages seemed to the surviving authors to require that the paper be indexed under his name. 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