THE EFFECT OF SPECIFIC AGENTS EXTRACTED FROM SOIL MICROÖRGANISMS UPON EXPERIMENTAL BACTERIAL INFECTIONS
Authors: René J. Dubos
Journal: Annals of Internal Medicine (1940)

Article1 May 1940THE EFFECT OF SPECIFIC AGENTS EXTRACTED FROM SOIL MICROÖRGANISMS UPON EXPERIMENTAL BACTERIAL INFECTIONSRENÉ J. DUBOSRENÉ J. DUBOSSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-13-11-2025 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptOrganic matter does not accumulate in nature; it rapidly becomes the prey of countless species of microörganisms which break it down, stepwise, to carbon dioxide, water, ammonia, and mineral salts. It is known moreover that, under natural conditions, each one of these microbial species is adapted to the performance of a limited, well-defined biochemical task. It seems certain, therefore, that one can find in nature microörganisms selectively adapted to the decomposition of almost every conceivable type of organic compound.9Like all living cells, microörganisms carry out their biochemical function through the agency of enzymes and other catalysts. In many cases...Bibliography1. AVERY OT: Rôle of specific carbohydrates in pneumococcus infection and immunity, ANN. INT. MED., 1932, vi, 1. Google Scholar2. AVERY OT: Chemo-Immunologische Untersuchungen an Pneumokokken-Infektion und Immunität, Naturwissensch., 1933, xxi, 777. CrossrefGoogle Scholar3. AVERYDUBOS OTRJ: Protective action of specific enzyme against type III pneumococcus infection in mice, Jr. Exper. Med., 1931, liv, 73. CrossrefGoogle Scholar4. DUBOS RJ: Factors affecting yield of specific enzyme in cultures of bacillus decomposing capsular polysaccharide of type III pneumococcus, Jr. Exper. Med., 1932, lv, 377. CrossrefGoogle Scholar5. 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Y.*Read at the Cleveland meeting of the American College of Physicians, April 4, 1940.From The Hospital of The Rockefeller Institute for Medical Research. Nextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byRediscovery of antimicrobial peptides as therapeutic agentsGramicidin, Tyrocidine, and Tyrothricin1 Polypeptide Antibiotics of Medicinal InterestPolysaccharidasesDie AntibioticaTyrothricin in proctologyTyrothricinAntibiotic Substances, Production by Microörganisms—Nature and Mode of ActionSulfamethylthiazol therapy in pneumoniaBacteriostatic and bactericidal agents obtainedfrom saprophytic microorganisms 1 May 1940Volume 13, Issue 11Page: 2025-2037KeywordsAmmoniaCarbon dioxideCellsEnzymesSalts ePublished: 1 December 2008 Issue Published: 1 May 1940 Copyright & PermissionsCopyright, 1940, by The American College of PhysiciansPDF downloadLoading ...