tbuckley/cabot-search huggingface dataset:
Methylene Blue Staining of Dysplastic and Nondysplastic Barrett's Esophagus: An In Vivo and Ex Vivo Study
Authors: M. I. Canto, S. Setrakian, J. E. Willis, A. Chak, R. E. Petras, M. V. Sivak
Journal: Endoscopy (2001)

Background and Study Aims: Methylene blue selectively stains specialized columnar epithelium in Barrett's esophagus with high accuracy. We prospectively evaluated the methylene blue staining properties of dysplastic and nondysplastic Barrett's esophagus and the association of these properties with the risk for dysplasia and cancer.
STUDIES ON INFLUENZAL MENINGITIS
Authors: Hugh K. Ward, Joyce Wright
Journal: The Journal of Experimental Medicine (1932)

1. An acute purulent meningitis due to the invasion of the meninges by Pfeiffer's influenza bacillus is not a very uncommon disease ininfants and young children. It has a very high mortality. 2. Complement is entirely absent in the cerebrospinal fluid of these cases, and bactericidal experiments suggest that the injection of a specific antiserum will have but slight lethal effect on the organisms unless complement is injected at the same time. 3. Treatment with a mixture of specific antiserum and complement led in some cases to a definite clinical improvement, coincident with sterilization and clearing of the cerebrospinal fluid. But after some days, the patients relapsed and died. Autopsy showed localized abscesses in the vicinity of the base of the brain, the lesions being definitely walled off from the general subarachnoid space. In one case, the patient recovered. 4. Since the walls of the abscesses apparently present an insuperable mechanical obstacle to the action of the antiserum and complement, the possibility of preventing the formation of abscesses is discussed. Earlier diagnosis and more rapid sterilization are the most obvious measures. Bactericidal experiments indicate that the proportion of antiserum to complement may be an important factor in bringing about a more rapid elimination of the bacilli.
Fluoride-mediated activation of the respiratory burst in human neutrophils. A reversible process.
Authors: J T Curnutte, B M Babior, M L Karnovsky
Journal: Journal of Clinical Investigation (1979)

Fluoride ion (F-) is an effective activator of the respiratory burst in neutrophils, as indicated by its ability to induce O2- production by these cells. Other halide ions did not activate the burst, Cl-, in particular appeared to antagonize the effect of F- on O2- production. F- stimulated O2- production showed a requirement for Ca++, but was independent of other exogenous cations. Neither phagocytosis nor degranulation were necessary for respiratory burst activation by F-. The effect of F- on the respiratory burst was reversible. Washing the cells after treatment with F-, while they were still producing large amounts of O2-, returned them to the resting state. They could then be stimulated again to produce O2- in amounts equivalent to those originally produced. Our experiments indicated that restimulation did not represent the activation of a population of cells that had not been activated during the initial exposure to F-, nor did it represent serial activation of different subpopulation of the O2- forming enzyme molecules present in a given cell. Rather, our data suggest that the entire population of O2- forming enzyme molecules was activated in a reversible fashion by F-.
Expression and phosphorylation of rat c-met/hepatocyte growth factor receptor during rat liver regeneration
Authors: Masayoshi Horimoto, Norio Hayashi, Yutaka Sasaki, Toshifumi Ito, Yoshiki Ito, Shigeo Wada, Yuji Tanaka, Akira Kaneko, Hideyuki Fusamoto, Masaya Tohyama, Takenobu Kamada
Journal: Journal of Hepatology (1995)
Physician's Guide to Insulin-Dependent (Type I) Diabetes: Diagnosis and Treatment
Authors: Roger W. Turkington
Journal: JAMA (1989)

<h3>Physician's Guide to Non-Insulin-Dependent (Type II) Diabetes: Diagnosis and Treatment, by the American Diabetes Association, ed 2 (H. Rifkin, editor-in-chief), 98 pp, $18.45 paper, Alexandria, Va, American Diabetes Association, 1988.</h3> The volume on insulin-dependent (type I) diabetes and its companion manual (see below) have been prepared to provide primary-care physicians with practical information on current standards for diagnosis and management of diabetes mellitus. The two manuals form the nucleus of the clinical education program sponsored by the American Diabetes Association. Each manual has sections written by a board of contributing editors. A second board of consultants has collaborated with the authors to revise and edit each section. Finally, the consensus materials were evaluated for approval or modification by a panel of consultants designated by the following societies: American Academy of Family Physicians, American Academy of Ophthalmology, American College of Physicians, American Geriatrics Society, American Medical Association, American Osteopathic Association, American
A Phase 2, Non-Comparative, Open-Label, International Study of MEDI4736 in Patients with Locally Advanced or Metastatic PD-L1-Positive NSCLC (Stage IIIB-IV) Who have Received ≥ 2 Prior Systemic Treatment Regimens (Atlantic)
Authors: N. Rizvi, M. Ballas, D. Jayawardene, P.K. Stockman, J.D. Powderly
Journal: Annals of Oncology (2014)
The Surgeon's Rhyme: A Memoir; Bryson City Seasons: More Tales of a Doctor's Practice in the Smoky Mountains
Authors: Domhnall MacAuley
Journal: BMJ (2005)

Michael Barrie The Book Guild, £8.99, pp 192 ISBN 1 85776 813 2 Rating:![Graphic][1]</img>![Graphic][2]</img>![Graphic][3]</img>![Graphic][4]</img> Walt Larimore Zondervan, £13.50/$18.99/$C29.99, pp 320 ISBN 0 310 25287 3 www.zondervan.com Rating:![Graphic][5]</img>![Graphic][6]</img>![Graphic][7]</img>![Graphic][8]</img> T raumatic echoes of life as a junior doctor: the sickening stench of stale cigarettes and hospital starch strangled sleep. The doctors' on-call room, placed conveniently between the wards, was the daytime coffee room for nurses and auxiliaries. Clouds of smoke throughout the day lingered in the fabric of the bed. Any comment to the staff brought antagonism, so it was easier to say nothing. These were times forgotten, until Michael Barrie's The Surgeon's Rhyme brought flashbacks. He tells his story beautifully with drama, dialogue, and scratch and … [1]: /embed/inline-graphic-1.gif [2]: /embed/inline-graphic-2.gif [3]: /embed/inline-graphic-3.gif [4]: /embed/inline-graphic-4.gif [5]: /embed/inline-graphic-5.gif [6]: /embed/inline-graphic-6.gif [7]: /embed/inline-graphic-7.gif [8]: /embed/inline-graphic-8.gif
A Photogenic Hospital
Authors: John Lister
Journal: New England Journal of Medicine (1966)

LAST May the minister of health, Mr. Kenneth Robinson, opened an entirely new district hospital built on a beautiful site of nearly 70 acres (Fig. 1) to serve the busy neighboring industrial town of Slough in Buckinghamshire.The planning and building had taken nearly eleven years, but the final opening was nonetheless exciting. The long gestation period of hospitals is due to many factors. First of all, approval in principle has to be given by the Minister of Health. The Regional Hospital Board then sets up a project team, under the chairmanship of an administrative medical officer, that includes the . . .
NHS spending on drugs is frozen for two years under price deal
Authors: J. Wise
Journal: BMJ (2013)

NHS spending on branded medicines will be held flat for the next two years with increases of less than 2% in the following three years under a new voluntary deal with the pharmaceutical industry which comes into effect on 1 January 2014.

The Pharmaceutical Price Regulation Scheme is a voluntary agreement negotiated between the Association of British Pharmaceutical Industry (ABPI) and the Department of Health, on behalf of the NHS in England, Scotland, Wales, and Northern Ireland.1

This is the first time the government has set a fixed limit on NHS drug spending. Under the new scheme pharmaceutical companies will be required to rebate the difference between the allowed growth in the drugs bill and the estimated actual increase in the cost of treatments, which is estimated to be 3.74% in 2014. Costs will be allowed to rise by …
Study of the tolerance of infliximab infusions with or without betamethasone premedication in patients with active rheumatoid arthritis
Authors: J Sany
Journal: Annals of the Rheumatic Diseases (2005)

To assess the incidence of infusion reactions in patients with rheumatoid arthritis (RA) receiving infliximab treatment with and without betamethasone premedication. To determine whether patients with an atopic diathesis had a better response to corticosteroid pretreatment than those without, and the course of patients' functional capacity and quality of life.A prospective, multicentre, randomised, double blind phase 4 study of 355 patients with RA in two groups: group A received betamethasone and group B placebo, before a 36 week infusion treatment with infliximab. Incidence and severity of infusion reactions from infliximab treatment were assessed.The incidence of reactions to infliximab infusion was <5%. More infusion reactions occurred with betamethasone pretreatment than with placebo. Response to infliximab of patients with atopic backgrounds did not differ in the presence or absence of betamethasone from that of non-atopic patients. Mean Health Assessment Questionnaire score improved by 47% at week 24, quality of life assessed by Short Form-36 improved in mental and physical component subscales.Incidence of infusion reactions with infliximab was low and their severity generally mild, but betamethasone pretreatment did not decrease the incidence and severity of infusion reactions. Betamethasone, therefore, is not recommended as a systematic prophylactic measure, even in atopic patients.
The Airway Longitudinal Elastic Fiber Network and Mucosal Folding in Patients with Asthma
Authors: NEIL G. CARROLL, STEVEN PERRY, ARTEE KARKHANIS, SALIMA HARJI, JOHN BUTT, ALAN L. JAMES, FRANCIS H. Y. GREEN
Journal: American Journal of Respiratory and Critical Care Medicine (2000)

A submucosal network of elastic fibers in a collagen and myofibroblast matrix form discrete longitudinal bundles (LB) in the bronchial tree. The LB may affect airway function by altering the mechanical properties of the airway wall or by changing the folding behavior of the airway mucosa. The area and number of LB were quantified from 12 cases each of fatal asthma (FA), nonfatal asthma (NF), and nonasthmatic (NA) control cases on elastic-trichrome stained airways. The effects of group, sex, age, and smoking were examined using multiple linear regression. The area fraction of LB increased (p < 0.05) approximately twofold in cases of FA compared with NA control cases in both large and small airways. The areas of LB were increased in smokers, older subjects, and men (p < 0.05). The number of mucosal folds was related to the number of longitudinal bundles in asthmatics and nonasthmatics and was not different between groups. Collagen and myofibroblasts were increased (p < 0.05) in LB of FA and NF cases compared with NA control cases. The increased size and altered composition of LB in asthma may influence airway function; however, excessive airway narrowing in asthma is not due to altered numbers of mucosal folds. Carroll NG, Perry S, Karkhanis A, Harji S, Butt J, James AL, Green FHY. The airway longitudinal elastic fiber network and mucosal folding in patients with asthma.
OMERACT 7 psoriatic arthritis workshop: synopsis
Authors: D D Gladman
Journal: Annals of the Rheumatic Diseases (2005)

Outcome Measures in Rheumatology (OMERACT) conferences have developed a process by which outcome measures to be included in clinical trials are identified by consensus. During OMERACT 7, held in Asilomar, CA, USA, in May 2004, a workshop on outcome measures in psoriatic arthritis was held. Information derived through a previous Delphi exercise and nominal group process was shared with the participants, as were the results from a study using completed clinical trials with biological therapies. On the basis of the evidence presented and discussions in breakout groups at the OMERACT conference, a set of domains to be included in clinical trials in psoriatic arthritis was developed and a research agenda for further studies in psoriatic arthritis proposed.
Hepatoprotective effect of tumour necrosis factor α blockade in psoriatic arthritis: a cross-sectional study
Authors: Michael Seitz, Stephan Reichenbach, Burkhard Möller, Marcel Zwahlen, Peter M Villiger, Jean-Francois Dufour
Journal: Annals of the Rheumatic Diseases (2009)

To evaluate the impact of tumour necrosis factor alpha (TNFalpha) blockers on the presence of liver fibrosis in patients with rheumatoid arthritis (RA) and psoriatic arthritis (PsA) treated with methotrexate (MTX).Participants were consecutive patients with RA and PsA who had undergone MTX treatment for at least 1 year + or - TNF blockade for over 6 months. Liver fibrosis was assessed using non-invasive transient elastography (FibroScan). Regression models were used to compare FibroScan values of patients with RA and patients with PsA receiving TNFalpha blockers with those who were not.FibroScan assessments were performed on 51 patients with RA and 43 patients with PsA. Compared to patients with RA, those with PsA were predominantly young men, received lower cumulative dosages of MTX and exhibited a higher incidence of liver steatosis and hyperlipidaemia. An abnormal result was observed in 7.1% of the anti-TNFalpha-naïve and in 13% of the anti-TNFalpha-treated patients in the RA group and in 30% of the anti-TNFalpha-naïve and 4.3% of the anti-TNFalpha-treated patients in the PsA group (OR=0.11, 95% CI 0.02 to 0.98). Results of the PsA group were robust when adjusted for baseline characteristics.The results suggest a protective effect of TNFalpha inhibitors against the development of liver fibrosis in patients with PsA.
A Subject/Object Case
Authors: David A. Fisher
Journal: JAMA (1986)

In the balmier laissez-faire days of medicine, before the acronymous onslaught of QA committees, PRSOs, DRGs, and other attendant watchwords of the health of our health care, medical school—associated hospitals would retain or admit  for teaching purposes. One recalls the enthusiasm mixed with trepidation of working up, reading about, and presenting their fascinating and, at times, exotic problems. I still fondly remember several of these professional patients from my medical school days in Boston during the 1960s.  There was the man with periarteritis nodosa and his purple nodules and the fellow suffering from chemically induced myeloid metaplasia with myelofibrosis, his spleen barely palpable to our eager but inexperienced and not yet sensitive fingers. We compared the soft, scrofulous nodes of the tolerant lady in the isolation room with the rubbery cervical nodes swollen with lymphoma of the angry young man flashing glances of antipathy from his station on the
Abstract 3774: A novel drug discovery assay for analyzing autophagy in living cells
Authors: Dee Shen, Eric Chan, Praveen Pande, Jack Coleman, Wayne F. Patton
Journal: Cancer Research (2011)

Abstract Autophagy is a normal degradative pathway that involves the sequestration of entire organelles, protein complexes, and misfolded proteins in a membrane vacuole called the autophagosome. The autophagosomal vesicle is subsequently delivered to the lysosome where it is degraded into its essential constituents and recycled back to the cytoplasm. Autophagy plays an important role in diverse biological events, not only during conditions of nutrient limitation, but it also functions in tumor suppression, the immune response, and the prevention of certain types of neurodegeneration. However, experimental methods to monitor this process in mammalian cells are limited due to lack of autophagic markers. Recently, LC3, a mammalian homologue of the ubiquitin-like (UBL) protein Atg8, has been used as a specific marker of autophagosomes in mammals. However, current methods to quantify autophagic activity using LC3 are time-consuming and labor-intensive. We have developed and validated a novel cell-based autophagy assay using a 488 nm-excitable green-emitting fluorescent probe to highlight the various vacuolar components of the autophagy pathway. We demonstrated that the accumulation of autophagy probe was specifically induced by amino acid deprivation and was inhibited by 3-methlyadenine, a classical inhibitor of the autophagic pathway. Furthermore, a population of this dye-labeled vesicle co-localizes with LC3. We have validated this fluorescent probe with a wide range of conditions known to modulate autophagy pathways. The assay is compatible with flow cytometry, allowing, for the first time, easy quantitation of autophagy. This assay enables kinetic analysis of the autophagy pathway and is able to distinguish between increases in autophagic flux vs. autophagic vacuole accumulation. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 102nd Annual Meeting of the American Association for Cancer Research; 2011 Apr 2-6; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2011;71(8 Suppl):Abstract nr 3774. doi:10.1158/1538-7445.AM2011-3774
Fine-Needle Aspiration Biopsy of Patients with the Acquired Immunodeficiency Syndrome (AIDS): Experience in an Outpatient Clinic
Authors: KENT BOTTLES
Journal: Annals of Internal Medicine (1988)

One hundred twenty-one fine-needle aspiration biopsies of lymph nodes were done on 113 men followed in the AIDS (acquired immunodeficiency syndrome) Outpatient Clinic of the San Francisco General Hospital. The cytologic diagnoses on these 121 biopsies included 60 (50%) hyperplasias, 24 (20%) non-Hodgkin lymphomas, 21 (17%) mycobacterial infections, 12 (10%) cases of Kaposi sarcoma, and 1 each of Hodgkin disease, giant cell carcinoma, nasopharyngeal carcinoma, and squamous cell carcinoma. No false-positive results occurred in this series, but five false-negative results were seen in the 10 patients with hyperplasia on fine-needle aspiration biopsy specimens who subsequently had open surgical biopsy. From our experience, we believe fine-needle aspiration biopsy is a useful, cost-effective initial method to evaluate lymphadenopathy in patients seen at an AIDS outpatient clinic.
Homosexuality—A Risk Factor in Infectious Disease
Authors: Samuel Vaisrub
Journal: JAMA (1977)

Concentration on the moral, psychological, religious, social, and legal facets of homosexuality have long obscured its medical-epidemiologic ramifications. With the lifting of the fog of secrecy that surrounded the gay way of life, the vulnerability of the homosexual to diseases that are sexually transmitted but are not generally categorized as venereal (strictly speaking, Venus cannot be implicated in this situation, even if the disease is syphilis or gonorrhea) is becoming increasingly apparent. The inclusion of the mouth and anus within the orbit of sexual activity carries with it risks of exposure to enteric pathogens. It is thus not surprising that homosexual men have been reported to contract giardiasis,<sup>1</sup>shigellosis,<sup>2</sup>and amebiasis<sup>3</sup>in areas where these diseases are not endemic. In a retrospective scrutiny of the New York Hospital records during a five-year period, Schmerin and his associates (p 1386) noted that<i>Entamoeba histolytica</i>was found in the
Chemical and biological integration of a mouldable bioactive ceramic material capable of forming apatite in vivo in teeth
Authors: H. Engqvist, J.-E. Schultz-Walz, J. Loof, G.A. Botton, D. Mayer, M.W. Phaneuf, N.-O. Ahnfelt, L. Hermansson
Journal: Biomaterials (2003)
Public Health in Times of War and Famine
Authors: Ronald J. Waldman
Journal: JAMA (2001)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The effect of collagenase on surface markers of human peripheral lymphocytes
Authors: TULIP TAN
Journal: British Journal of Dermatology (1976)

The effect of collagenase on the 'T' and 'B' markers of peripheral blood lymphocytes was studied in five healthy male blood donors. No significant difference between untreated and collagenase treated lymphocytes was found. Collagenase is recommended for use in liberating living cells from skin biopsy specimens.
Hematuria and Cholethiasis With β-Thalassemia
Authors: Mason G. Robertson
Journal: JAMA (1972)

<h3>To the Editor.—</h3> Since the report of Goodwin et al<sup>1</sup>in 1950 of painless hematuria associated with sickle cell hemoglobinopathy, numerous reports have confirmed the phenomenon in both sickle cell (SS) trait and SS disease. Gunnels and Grim<sup>2</sup>have reported painless hematuria in A/D hemoglobinopathy. We have previously reported a case of recurrent painless hematuria in a patient with hemoglobin C trait.<sup>3</sup>The present report concerns a child with painless hematuria who had β-thalassemia trait associated with silent gall stones. A 5-year-old black American child was found on routine preschool examination to have significant microscopic hematuria. Complete urological evaluation revealed no abnormality but x-ray films showed radiopaque gall stones. Results of hematological evaluation included a hemoglobin level of 10.8 gm/100 ml, normal bilirubin level, and normal reticulocyte count. Hemoglobin electrophoresis however revealed an A<sub>2</sub>hemoglobin value of 4.3%. Analysis of the parents revealed normal hematograms for both
THE MANAGEMENT OF MEASLES IN HOSPITAL AND HOME
Authors: HENRY JAMES SPENCER
Journal: JAMA (1927)

In the management of measles one may have to deal with (1) the prevention or modification of a threatened attack in exposed, susceptible patients; (2) the treatment of developed, uncomplicated cases and the utmost prevention of complications, or (3) the treatment of established complications. The angle of approach differs somewhat in (<i>a</i>) a contagious disease hospital; (<i>b</i>) a general hospital, especially the pediatric wards, and (<i>c</i>) a home. The problem of handling exposed susceptible patients arises mainly in the general hospital and the home. I may go a step farther back and speak for a moment of the prevention of exposure. This matter is of great importance in the age group under 5 years. The great mortality of measles lies here (tables 1 and 2). <h3>PREVENTION OF EXPOSURE</h3> There is little hope of preventing exposure in the great majority of homes for some time to come; the "danger group," as