tbuckley/cabot-search huggingface dataset:
The clinical features of isolated left circumflex coronary artery disease.
Authors: R F Dunn, H N Newman, L Bernstein, P J Harris, G S Roubin, J Morris, D T Kelly
Journal: Circulation (1984)

The clinical characteristics of 84 patients with isolated circumflex disease (greater than or equal to 70% luminal stenosis) were reviewed. A total of 66 patients had angina pectoris (mean duration 17.3 months), and 60 had suffered a myocardial infarction. Risk factors averaged 2.2 per patient. In the 84 patients there were 103 discrete circumflex stenoses; 51 stenoses were central (proximal circumflex, obtuse marginal, and intermediate branches), and 52 were peripheral (distal circumflex, posterolateral, and posterior descending branches); 48 were total and 55 were subtotal. Left ventricular function was normal in 21 patients and abnormal in 63 patients, but the mean left ventricular ejection fraction of the group was normal (59 +/- 12%). Eighty-two patients had abnormal electrocardiograms: there were Q waves in 25, RV pattern in 43, ST-T wave abnormalities in 19, left bundle branch block in two, and pacemaker rhythm in one. Inferior abnormalities on the electrocardiogram correlated with peripheral stenoses (p less than .02), and lateral abnormalities on the electrocardiogram correlated with central stenoses (p less than .01). The RV pattern of true posterior infarction was seen in both central and peripheral stenoses. In the 32 patients who underwent thallium scanning, lateral defects were more common with central stenoses, but posterolateral defects occurred similarly in central and peripheral stenoses. Prognosis was good. There were two deaths during the mean follow-up time of 17 months (range 1 to 49). The cumulative survival rate was 100% at 12 months, 97.5 +/- 2.9% at 24 months, and 97.5 +/- 3.6% at 30 months.
Novel gain-of-function mutation in the extracellular domain of the PDGFRA gene in infant acute lymphoblastic leukemia with t(4;11)(q21;q23)
Authors: M Hiwatari, R Ono, T Taki, A Hishiya, E Ishii, T Kitamura, Y Hayashi, T Nosaka
Journal: Leukemia (2008)
Royal college calls for smoking ban in cars
Authors: J. Wise
Journal: BMJ (2010)

<h3>Introduction</h3> Adherence to cardioprotective dietary patterns can reduce risk for developing cardiometabolic disease. Rates of diet assessment and counselling by physicians are low. Use of a diet screener that rapidly identifies individuals at higher risk due to suboptimal dietary choices could increase diet assessment and brief counselling in clinical care. <h3>Methods</h3> We evaluated the relative validity and reliability of a 9-item diet risk score (DRS) based on the Healthy Eating Index (HEI)-2015, a comprehensive measure of diet quality calculated from a 160-item, validated food frequency questionnaire (FFQ). We hypothesised that DRS (0 (low risk) to 27 (high risk)) would inversely correlate with HEI-2015 score. Adults aged 35 to 75 years were recruited from a national research volunteer registry (ResearchMatch.org) and completed the DRS and FFQ in random order on one occasion. To measure reliability, participants repeated the DRS within 3 months. <h3>Results</h3> In total, 126 adults (87% female) completed the study. Mean HEI-2015 score was 63.3 (95% CI: 61.1 to 65.4); mean DRS was 11.8 (95% CI: 10.8 to 12.8). DRS and HEI-2015 scores were inversely correlated (r=−0.6, p&lt;0.001; R<sup>2</sup>=0.36). The DRS ranked 37% (n=47) of subjects in the same quintile, 41% (n=52) within ±1 quintile of the HEI-2015 (weighted κ: 0.28). The DRS had high reliability (n=102, ICC: 0.83). DRS mean completion time was 2 min. <h3>Conclusions</h3> The DRS is a brief diet assessment tool, validated against a FFQ, that can reliably identify patients with reported suboptimal intake. Future studies should evaluate the effectiveness of DRS-guided diet assessment in clinical care. <b>Trial registration details</b> ClinicalTrials.gov (NCT03805373).
Effects of Exercise Training on Health Status in Patients With Chronic Heart Failure
Authors: Kathryn E. Flynn, Ileana L. Piña, David J. Whellan, Li Lin, James A. Blumenthal, Stephen J. Ellis, Lawrence J. Fine, Jonathan G. Howlett, Steven J. Keteyian, Dalane W. Kitzman, William E. Kraus, Nancy Houston Miller, Kevin A. Schulman, John A. Spertus, Christopher M. O’Connor, Kevin P. Weinfurt
Journal: JAMA (2009)

IS A SYNDROME characterized by dyspnea and fatigue; however, patients with heart failure often also experience diminished health status, including reductions in physical and social functioning and other dimensions of health-related quality of life. 1,2harmacological and device interventions and disease management programs for heart failure have provided little or modest improvements in healthrelated quality of life. 3,4The extent to which exercise training in addition to optimal evidence-based therapy improves patients' health status is unknown.
812 PERCUTANEOUS TREATMENT OF HEPATOCELLULAR CARCINOMA. SYSTEMATIC REVIEW AND META- ANALYSIS
Authors: M. Pleguezuelo, G. Germani, K. Gurusamy, V. Calvaruso, P. Manousou, V. Arvaniti, C. Triantos, A.K. Burroughs
Journal: Journal of Hepatology (2009)
Abstract 5611: A synthetic lethality combination with chloroquine and rapamycin on chemosensitization
Authors: Yu-shan Wang, Yi-Chun Huang, Weng-Lam Fong, Mau-Shin Chi, Kwan-Hwa Chi
Journal: Cancer Research (2012)

Abstract Chemoresistance is the main obstacle of successful cancer therapy. Autophagy may either enhance cancer cell death or activate chemoresistance. Simultaneous pushing and blocking of autophagy may be a valid strategy for overcoming drug resistance and improving responses. We hypothesized that simultaneous forcing hepatoma cells synchronized in a pro-autophagic status by rapamycin while blocking the final autophagic pathway by chloroquine is an example of synthetic lethality in synergism. Co-administration of the chemotherapeutic agents with rapamycin and chloroquine in 3 hepatoma cell lines have all demonstrated synergistic effects including 5-fluorouracil, navelbine, taxotere or cisplatin. Increasing doses of rapamycin and chloroquine resulted in a significant decrease of ED50 of different chemodrugs. Althrough hepatoma cell lines expressed difference status of autophage during various chemodrug treatments, co-administration of rapamycin and chloroquine could synchronize them on the pro-autophagic status while preveting them ensuring to the final autophagic status in all cell line tested. The combination of rapamycin and chloroquine and chemotherapeutic agents resulted in increased apoptotic cell death compared to chemotherapeutic agents alone. All of the observed synergistic chemosensitization effect from combination of chloroquine and rapamycin is more obvious than either agent alone. In vivo experiments are underway. If these synergistic effects can be reproduced in vivo, the combination of rapamycin and chloroquine may provide a valid reversing resistance strategy in treatment refractory cancer patients. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 103rd Annual Meeting of the American Association for Cancer Research; 2012 Mar 31-Apr 4; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2012;72(8 Suppl):Abstract nr 5611. doi:1538-7445.AM2012-5611
Photoactivated Composite Biomaterial for Soft Tissue Restoration in Rodents and in Humans
Authors: Alexander T. Hillel, Shimon Unterman, Zayna Nahas, Branden Reid, Jeannine M. Coburn, Joyce Axelman, Jemin J. Chae, Qiongyu Guo, Robert Trow, Andrew Thomas, Zhipeng Hou, Serge Lichtsteiner, Damon Sutton, Christine Matheson, Patricia Walker, Nathaniel David, Susumu Mori, Janis M. Taube, Jennifer H. Elisseeff
Journal: Science Translational Medicine (2011)

Photoactivated composite poly(ethylene glycol)–hyaluronic acid biomaterials demonstrate enhanced physicochemical properties for facial soft tissue reconstruction.
Effect of inhaled corticosteroid on an immunoreactive thymus and activation-regulated chemokine expression in the bronchial biopsies from asthmatics
Authors: M. Hoshino, T. Nakagawa, Y. Sano, K. Hirai
Journal: Allergy (2005)

Background: Bronchial asthma is characterized by airway inflammation, notably because of eosinophils and T cells. Thymus and activation‐regulated chemokine (TARC) is known to selectively attract Th2 cells, and is increased in response to interleukin (IL)‐4 and IL‐13, which share a common receptor, IL‐4 receptor alpha (IL‐4R α ). While corticosteroids have proven, very effective in modifying airway inflammation, the effect of corticosteroids on TARC in asthmatics has been little studied. Objective: We examined the effects of inhaled budesonide (BUD) on the expression of TARC and the number of inflammatory cells in bronchial biopsy specimens taken from asthma patients. Methods: Inhaled BUD 800 μ g daily, or placebo was administered for 3 months in a double‐blind, parallel‐group study, and bronchial biopsies were performed before and after treatment. Biopsy specimens were examined by immunocytochemistry. Results: We observed a significant decrease in the epithelial expression of TARC ( P &lt; 0.01) in the BUD group compared with the placebo group. This was accompanied by decreases in the number of eosinophils ( P &lt; 0.01), CD3 + T cells ( P &lt; 0.05), and CD4 + T cells ( P &lt; 0.01). A significant correlation was found between changes in epithelial TARC and in IL‐4R α immunoreactivity ( r s = 0.66, P &lt; 0.01). Conclusions: These findings suggest that corticosteroid asthma treatment can reduce infiltration of the airway by inflammatory cells, an effect modulated by down‐regulation of bronchial epithelial TARC expression.
Adrenergic mechanisms contribute to the late phase of hypoglycemic glucose counterregulation in humans by stimulating lipolysis.
Authors: C G Fanelli, P De Feo, F Porcellati, G Perriello, E Torlone, F Santeusanio, P Brunetti, G B Bolli
Journal: Journal of Clinical Investigation (1992)

Three studies were performed on nine normal volunteers to assess whether catecholamine-mediated lipolysis contributes to counterregulation to hypoglycemia. In these three studies, insulin was intravenously infused for 8 h (0.30 mU.kg-1.min-1 from 0 to 180 min, and 0.40 mU.kg-1.min-1 until 480 min). In study I (control study), only insulin was infused; in study II (direct + indirect effects of catecholamines), propranolol and phentolamine were superimposed to insulin and exogenous glucose was infused to reproduce the same plasma glucose (PG) concentration of study I. Study III (indirect effect of catecholamines) was the same as study II, except heparin (0.2 U.kg-1.min-1 after 80 min), 10% Intralipid (1 ml.min-1 after 160 min) and variable glucose to match PG of study II, were also infused. Glucose production (HGO), glucose utilization (Rd) [3-3H]glucose, and glucose oxidation and lipid oxidation (LO) (indirect calorimetry) were determined. In all three studies, PG decreased from approximately 4.8 to approximately 2.9 mmol/liter (P = NS between studies), and plasma glycerol and FFA decreased to a nadir at 120 min. Afterwards, in study I plasma glycerol and FFA increased by approximately 75% at 480 min, but in study II they remained approximately 40% lower than in study I, whereas in study III they rebounded as in study I (P = NS). In study II, LO was lower than in study I (1.69 +/- 0.13 vs. 3.53 +/- 0.19 mumol.kg-1.min-1, P less than 0.05); HGO was also lower between 60 and 480 min (7.48 +/- 0.57 vs. 11.6 +/- 0.35 mumol.kg-1.min-1, P less than 0.05), whereas Rd was greater between 210 and 480 min (19 +/- 0.38 vs. 11.4 +/- 0.34 mumol.kg-1.min-1, respectively, P less than 0.05). In study III, LO increased to the values of study I; between 4 and 8 h, HGO increased by approximately 2.5 mumol.kg-1.min-1, and Rd decreased by approximately 7 mumol.kg-1.min-1 vs. study II. We conclude that, in a late phase of hypoglycemia, the indirect effects of catecholamines (lipolysis mediated) account for at least approximately 50% of the adrenergic contribution to increased HGO, and approximately 85% of suppressed Rd.
NITROGEN AND NUCLEIN METABOLISM IN GOUT
Authors: P. A. Levene, Leo Kristeller
Journal: The Journal of Experimental Medicine (1912)

Thus, our conclusions harmonize with those of Brugsch and Schittenhelm in so far as they are concerned with the nuclein metabolism. They add, however, the observation that the elimination of nitrogenous substances of protein origin has a protracted character, and that the oxidation of as simple a substance as asparagin proceeds at a subnormal rate. The most striking peculiarity observed in our patient was the very imperfect elimination of ingested urea when the patient was placed on a diet containing only six grams of nitrogen per day, and a much more complete elimination when the diet contained thirteen grams of nitrogen.
Prevention of coronary thrombosis with subthrombolytic doses of tissue-type plasminogen activator.
Authors: K A Fox, A K Robison, R M Knabb, T L Rosamond, B E Sobel, S R Bergmann
Journal: Circulation (1985)

To determine whether tissue-type plasminogen activator (t-PA) may prevent coronary thrombosis or accelerate the lysis of clot formed under conditions in which increased concentration of the activator is present before thrombosis, clot lysis studies were undertaken in vitro and in vivo. In vitro, exogenous t-PA (6 to 100,000 ng/ml) accelerated the lysis of clot in a dose-dependent fashion when the clot was formed either from whole plasma or from euglobulin fractions (n = 316 determinations). Adding t-PA before clot formation shortened the time to lysis by at least threefold with euglobulin fractions and by at least 10-fold with whole plasma clots, which is consistent with the presence of inhibitors of fibrinolysis in whole plasma and with the binding of t-PA to nascent fibrin. In an intact dog preparation of coronary thrombosis (n = 25), occlusive thrombus formation was prevented when t-PA was present in subthrombolytic concentrations (430 to 1200 ng/ml, n = 5). Occlusive thrombus formation occurred after only discontinuation of the t-PA infusion and clearance of t-PA. Lower concentrations of t-PA (147 to 427 ng/ml, n = 6) significantly delayed occlusion (26 +/- 6.5 vs 7.8 +/- 2.8 min for controls). In animals with t-PA concentrations of less than 140 ng/ml (n = 4), the time to occlusion was unaltered (7.7 +/- 4.5 min). The present study demonstrates that t-PA present before clot formation inhibits thrombosis or accelerates thrombolysis depending on concentration, and that subthrombolytic doses of t-PA can prevent thrombus formation in vivo.(ABSTRACT TRUNCATED AT 250 WORDS)
Red Blood Cell Volume in Preterm Neonates
Authors: Quaife, J.W. Dirksen, C.L. Paxson, R.H. McIntire
Journal: Clinical Nuclear Medicine (1981)

In the high-risk neonate, the direct determination of the red cell volume by radionuclide dilution technique appears to be the singularly definitive method of defining treatment efficacy, and is thus a useful evaluation and management tool for the pediatrician. For effective patient management, the red blood cell(RBC) volume of 69 preterm and term neonates was determined. The method utilized, Tc-99m-labeled RBCs, provided a fast and accurate answer with a large reduction in the absorbed radiation dose. In the population studied within a high-risk newborn ICU, the mean RBC volumes between the preterm and term neonates were without significant difference. Grouping and analysis of the RBC volume data with respect to birth weight, gestational ages, and 1- and 5-minute Apgar scores revealed on statistical difference. The mean value found in our population, 32.2 +/- 9.2 ml/kg, however, does differ from those previously reported in which the determinations were made using an indirect estimation from the plasma compartment.
Implications of prominent cytologic dysplasia persisting in the marrow of a patient with CML even after the spontaneous disappearance of the Philadelphia chromosome
Authors: G. M. Janković, A. D. Bogdanović, M. D. Čolović, A. V. Novak, M. Andolina, A. Anagnostopoulos
Journal: American Journal of Hematology (1996)
Localization of specific carbohydrate configurations in human skin using fluorescein-labelled lectins
Authors: P.J.A. HOLT, J. HILLANGLIN, R.E. NORDQUIST
Journal: British Journal of Dermatology (1979)

The binding of three fluorescein-labelled lectins by normal human skin has been studied. The patterns of bound fluorescence seen were characteristic for each lectin, indicating that saccharide residues were available for lectin localization in the skin. Concanavalin A (glucose and mannose specific) and ricin 120 (galactose specific) presented similar patterns of localization of fluorescence in the epidermis and dermis. Both lectins presented a continuous band at the dermo--epidermal junction, but with concanavalin A the band was broader, while with ricin 120 the junctional band was thinner and more closely associated with the epidermal interface. With the peanut lectin (galactose specific) fluorescence outlined the periphery of the keratinocytes in the upper Malpighian and granular cell layers only; no junctional band was seen and the dermal appendages and collagen did not fluoresce. The stratum corneum did not fluoresce with any of the lectins studied.
Localization of Accessory Renal Artery Infarction Using Tc-99m DMSA Scintigraphy
Authors: Aysegul Dirlik, S Sureyya Ozbek, Huseyin Toz, Cuneyt Hoscoskun, Zehra Ozcan
Journal: Clinical Nuclear Medicine (2004)

The presence of accessory renal arteries has been considered a relative contraindication in the setting of a live related renal transplant program. Failure to properly anastomose the arteries can cause segmental infarction leading to increased morbidity. The authors describe a transplant patient with a well-defined cortical defect on a Tc-99m DMSA study, which was caused by a vascular complication. Although Tc-99m DTPA scintigraphy revealed the hypoperfused area, Tc-99m DMSA provided better delineation of the infarcted parenchymal zone.
ALL YEAR MEDICAL STUDY AND THE EDUCATION OF MEDICAL OFFICERS
Authors: GEORGE DOCK
Journal: JAMA (1918)

The value of a negative reaction has been studied and its reliability confirmed by the negative reactions obtained in nonsyphilitic affections of the skin.In a series of necropsies in which it was demonstrated pathologically that the aorta was free from syphilitic disease, negative reactions were obtained in 91 per cent.The conclusions of Dr. Symmers and his co-workers are shown to be fallacious and a misrepresentation of facts owing to :1.The apparent disregard of the different results obtained by various sérologie methods and the employ- ment of a questionable technic.2. The careless survey of pathologic material.
Value of routine chest radiography of psychiatric patients.
Authors: J Hughes, B M Barraclough
Journal: BMJ (1980)

metastases.She was aware of her diagnosis but declined further treatment and was discharged home. Comparison of nicotine chewing-gum and psychological treatments for dependent smokersWe regret that an error occurred in this paper by Mr Martin Raw and others (16 August, p 481).In table I the figures in the last two rows in the column headed "Nicotone gum" should have read "30(43)" and 35(51).
Turns of Phrase
Authors: George N. Braman
Journal: Annals of Internal Medicine (2005)

Ad Libitum19 July 2005Turns of PhraseGeorge N. Braman, MDGeorge N. Braman, MDFrom Bronx, NY 10471.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-143-2-200507190-00015 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail “You are the boring type,” by which he meantNot that I was dull, but easily bored.To such strange turns his words were sometimes bent,Imperfect flask in which his thoughts were poured.Yet his English was quite good, not taintedWith qualifiers but pointedly straight;I understood the portrait he painted,What measure he took of men, and what weight.We had a chief who never smiled, his sourGaze appearing in the elevator—“Don't you like us anymore? You glower,Your face on the floor.” Brave innovator!He called one of our students “a clean boy”—No bad habits, no guile—a friend, a joy.George N. Braman, MDBronx, NY 10471... Author, Article, and Disclosure InformationAffiliations: From Bronx, NY 10471.Current Author Address: George N. Braman, MD, 6142 Delafield Avenue, Bronx, NY 10471. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 19 July 2005Volume 143, Issue 2Page: 145KeywordsHabits ePublished: 19 July 2005 Issue Published: 19 July 2005 Copyright & PermissionsCopyright © 2005 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Book: Bioterrorism: Guidelines for Medical and Public Health Management
Authors: M. Reacher
Journal: BMJ (2003)

The extent and type of financial fraud committed by listed firms in China, stock market reaction to the detection and announcement of fraud, and the association between institutional ownership and financial fraud are the subjects of this article. Using fraud data from the period between 2001 and 2011, the authors find wide occurrences of fraud and a strong negative market reaction on the announcement date, particularly in cases of serious fraud. Fraud is more likely to occur at firms that have a smaller proportion of independent directors and at poorly performing firms. Firms with higher mutual fund ownership subsequently have fewer incidences of fraud. Our results reports by the authors indicate that ownership by independent institutions, such as mutual funds, serves as an effective monitoring mechanism, deterring fraud and enhancing corporate governance in Chinese capital markets. <b>TOPICS:</b>Emerging, portfolio management/multi-asset allocation, mutual funds/passive investing/indexing
Effects of a new loop diuretic (muzolimine) in cirrhosis with ascites: Comparison with furosemide
Authors: Mauro Bernardi, Rossana De Palma, Franco Trevisani, Costanza Santini, Daniela Patrono, Roberto Motta, Donatella Servadei, Govanni Gasbarrini
Journal: Hepatology (1986)

Muzolimine is a loop diuretic with both the dosedepend increasing effectiveness of loop diurexctics and the long-lasting effect of thiazides. This is a potential advantage in the treatment of ascites in advanced cirrhosis since these patients have a low tolerance to sudden reductions of blood volume. Equivalent single, oral doses of furosemide (40 mg) and muzolimine (30 mg) were given to 10 cirrhotic patients with ascites and reduced renal perfusion (glomerular filtration rate=30 to 75 ml per min). The study was preceded by 4 days of equilibration (dietary sodium 40 mmoles per day), and the drugs were alternated via a single-blind, cross-over protocol after a wash-out period of 3 days. Renal function was monitored under basal conditions and after diuretic administration through 4-hr clearance periods for 24 hr. The reninaldosterone axis was evaluated before diuretic administration and after 8 and 24 hr. Muzolimine led to a 12-hr cumulative diuresis [AUC 0−2 =2.52 ± 0.42 (S.E.) ml per min] and natriuresis (5.14 ± 1.05 mmoles per hr), which were comparable to those of furosemide (2.85 ± 0.29 ml per min and 6.75 ± 1.63 mmoles per hr). Its effect, however, was distributed over a longer period (8 hr) than furosemide (4 hr). Muzolimine activity mainly-differed from furosemide because of: significantly lower 12-hr potassium excretion (AUC 0−2 =0.28 ± 0.82 vs. 2.69 ± 0.46 mmoles per hr; p&lt;0.005); greater sodium/ chloride excretion ratio (0.45 ± 0.08 vs. 0.26 ± 0.06; p&lt;0.025), and absence of rebound phenomena. These were clearly evident with furosemide, involving both the glomerular filtration rate and renal ion excretions from the third clearance period. Finally, plasma renin activity significantly increased 24 hr after furosemide (from 1.66 ± 0.40 to 2.35 ± 0.60 ng per ml per hr; p&lt;0.05), whereas it was not affected by muzolimine administration. These findings suggest that muzolimine use in the treatment of ascites in cirrhosis may be followed less easily by complications, such as diureticinduced uremia and metabolic alkalosis, as compared to other loop diuretics.