tbuckley/cabot-search huggingface dataset:
Modern Coronary Care
Authors: Alvin H. Freiman
Journal: JAMA (1990)

One approaches the review of any book whose title starts with "Modern," "Current," or "Recent Advances" with grave misgivings. It is inevitable that, with the arrival of the monthly avalanche of journals, an increasing percentage of any such book will turn out to be a summary of past practices rather than of present procedure and concepts. The problem of obsolescence is compounded when the book is expensive. Any book that deals with "modern care" in a situation in which there is rapid change is essentially taking a snapshot of a moving kaleidoscope, as the authors acknowledge in the preface to this volume. Concepts and methods of myocardial reperfusion, pharmacologic support and therapy, angioplasty, and other mechanical approaches, together with continuing advances in diagnostic modalities, travel along a continuum. The editors have fully recognized all of the above caveats and have carved out a commendable niche. Their objective is to update
The General Internist—Another Dinosaur?
Authors: Norman J. Dreher
Journal: Annals of Internal Medicine (1992)

Letters1 April 1992The General Internist—Another Dinosaur?Norman J. Dreher, MDNorman J. Dreher, MDSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-116-7-606_1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editors: Your editorial (1) spurred me to write. I am very pleased to see someone support continued general medical care. I agree with you that the subspecialization of medicine has resulted in a fractionation of care.General internists must continue to provide comprehensive care for common diseases, such as hypertension, rheumatoid arthritis, and diabetes. Many of our peers are now referring cases to subspecialists because of fear of medical-legal repercussions and because of a general loss in their knowledge, because of their practice of frequent referral.Further reward for providing comprehensive care is necessary; nowadays, it is difficult...Reference1. Fletcher S and Fletcher R. Internal medicine: Whole or in pieces? [Editorial]. Ann Intern Med. 1991;115:978-9. LinkGoogle Scholar1. Fletcher S and Fletcher R. Internal medicine: Whole or in pieces? [Editorial]. Ann Intern Med. 1991;115:978-9. LinkGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: Norman J. Dreher, MD PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 April 1992Volume 116, Issue 7Page: 606-606KeywordsChemical fractionationFearHypertensionRheumatoid arthritisSub-specialty care ePublished: 1 December 2008 Issue Published: 1 April 1992 PDF downloadLoading ...
Cholelithiasis Demonstrated on Hepatobiliary Scintigraphy as a Photopenic Defect Within the Inferior Portion of the Liver
Authors: ALBERT J. MORENO, MICHAEL A. YEDINAK, GOTTLIEB L. TURNBULL, MELVIN J. SPICER, TOMMY J. BROWN
Journal: Clinical Nuclear Medicine (1984)

A 47–year–old man presented with the clinical findings of acute cholecystitis. During hepatobiliary scintigraphy using Tc–99m DISIDA, a persistent photopenic defect was noted within the inferior portion of the liver in the region of the gallbladder. Abdominal ultrasonography revealed large gallstones with acoustic shadowing within a normal–sized gallbladder. Eleven large gallstones were found within a normal–sized intrahepatic gallbladder at surgery.
Emergency feasibility in medical intensive care unit of extracorporeal life support for refractory cardiac arrest
Authors: Bruno Mégarbane, Pascal Leprince, Nicolas Deye, Dabor Résière, Gilles Guerrier, Samia Rettab, Jonathan Théodore, Souheil Karyo, Iradj Gandjbakhch, Frédéric J. Baud
Journal: Intensive Care Medicine (2007)
European guidelines for quality assurance in colorectal cancer screening and diagnosis. First Edition – Introduction
Authors: I. Lansdorp-Vogelaar, L. Karsa
Journal: Endoscopy (2012)

Multidisciplinary, evidence-based guidelines for quality assurance in colorectal cancer screening and diagnosis have been developed by experts in a project coordinated by the International Agency for Research on Cancer. The full guideline document covers the entire process of population-based screening. It consists of 10 chapters and over 250 recommendations, graded according to the strength of the recommendation and the supporting evidence. The 450-page guidelines and the extensive evidence base have been published by the European Commission. The first chapter deals with the evidence for the effectiveness of CRC screening; key operational parameters such as age-range, interval between two negative screening examinations, and some combinations of tests; and cost-effectiveness. The content of the chapter is presented here to promote international discussion and collaboration by making the principles and standards recommended in the new EU Guidelines known to a wider professional and scientific community. Following these recommendations has the potential to enhance the control of colorectal cancer through improvement in the quality and effectiveness of the screening process, including multi-disciplinary diagnosis and management of the disease.
Tiotropium improved lung function and delayed exacerbations in poorly controlled asthma
Authors: Michael Greenstone
Journal: Annals of Internal Medicine (2012)

ACP Journal Club18 December 2012Tiotropium improved lung function and delayed exacerbations in poorly controlled asthmaMichael Greenstone, MDMichael Greenstone, MDCastle Hill Hospital, Cottingham, England, UK (M.G.)Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-157-12-201212180-02003 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail Source CitationKerstjens HA, Engel M, Dahl R, et al. Tiotropium in asthma poorly controlled with standard combination therapy. N Engl J Med. 2012;367:1198-207. https://pubmed.ncbi.nlm.nih.gov/22938706Clinical Impact RatingsGIM/FP/GP: Hospitalists: Allerg & Immunol: Pulmonology: References1 Tashkin DP, Celli B, Senn S, et al; UPLIFT Study Investigators. A 4-year trial of tiotropium in chronic obstructive pulmonary disease. N Engl J Med. 2008;359:1543-54. [PMID: 18836213] Google Scholar2 Vogelmeier C, Hederer B, Glaab T, et al; POET-COPD Investigators. Tiotropium versus salmeterol for the prevention of exacerbations of COPD. N Engl J Med. 2011;364:1093-1103. [PMID: 21428765] Google Scholar3 Global Initiative for Asthma (GINA). Global Strategy for Asthma Management and Prevention; revised 2011. www.ginasthma.org (accessed 7 Nov 2012). Google Scholar4 Singh S, Loke YK, Enright PL, Furberg CD. Mortality associated with tiotropium mist inhaler in patients with chronic obstructive pulmonary disease: systematic review and meta-analysis of randomised controlled trials. BMJ. 2011;342:d3215. [PMID: 21672999] Google Scholar Author, Article, and Disclosure InformationAffiliations: Castle Hill Hospital, Cottingham, England, UK (M.G.)This article was published at Annals.org on 4 December 2012. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byLong-acting anticholinergics in the treatment of asthma 18 December 2012Volume 157, Issue 12Page: JC6-3KeywordsAsthmaLungsPulmonary medicineQuality of lifeQuestionnairesTreatment guidelines ePublished: 18 December 2012 Issue Published: 18 December 2012 Copyright & PermissionsCopyright © 2012 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Propensity Analysis of Long-Term Survival After Surgical or Percutaneous Revascularization in Patients With Multivessel Coronary Artery Disease and High-Risk Features
Authors: Sorin J. Brener, Bruce W. Lytle, Ivan P. Casserly, Jakob P. Schneider, Eric J. Topol, Michael S. Lauer
Journal: Circulation (2004)

Background— Although most randomized clinical trials have suggested that long-term survival rates after percutaneous coronary intervention (PCI) or surgical multivessel coronary revascularization (CABG) are equivalent, some post hoc analyses in high-risk groups and adjustment for severity of coronary disease have suggested higher mortality after PCI. Methods and Results— We studied 6033 consecutive patients who underwent revascularization in the late 1990s. PCI was performed in 872 patients; 5161 underwent CABG. Half the patients had significant left ventricular dysfunction or diabetes. Propensity analysis to predict the probability of undergoing PCI according to 22 variables and their interactions was used. The C-statistic for this model was 0.90, indicating excellent discrimination between treatments. There were 931 deaths during 5 years of follow-up. The 1- and 5-year unadjusted mortality rates were 5% and 16% for PCI and 4% and 14% for CABG (unadjusted hazard ratio, 1.13; 95% CI, 1.0 to 1.4; P =0.07). PCI was associated with an increased risk of death (propensity-adjusted hazard ratio, 2.3; 95% CI, 1.9 to 2.9; P &lt;0.0001). This difference was observed across all categories of propensity for PCI and in patients with diabetes or left ventricular dysfunction. Other independent predictors of mortality ( P ≤0.01 for all) were renal dysfunction, age, diabetes mellitus, chronic lung disease, peripheral vascular disease, left main trunk stenosis, and extent of coronary disease (Duke angiographic score). Conclusions— In patients with multivessel coronary artery disease and many high-risk characteristics, CABG was associated with better survival than PCI after adjustment for risk profile.
Blood Pressure and Heart Rate Over 10 Years in the Multimodal Treatment Study of Children With ADHD
Authors: Benedetto Vitiello, Glen R. Elliott, James M. Swanson, L. Eugene Arnold, Lily Hechtman, Howard Abikoff, Brooke S.G. Molina, Karen Wells, Timothy Wigal, Peter S. Jensen, Laurence L. Greenhill, Jonathan R. Kaltman, Joanne B. Severe, Carol Odbert, Kwan Hur, Robert Gibbons
Journal: American Journal of Psychiatry (2011)

It is unknown whether prolonged childhood exposure to stimulant medication for the treatment of attention deficit hyperactivity disorder (ADHD) increases the risk for developing abnormalities in blood pressure or heart rate. The authors examined the association between stimulant medication and blood pressure and heart rate over 10 years.
PROPHYLAXIS OF PUERPERAL SEPSIS
Authors: HAROLD A. MILLER
Journal: JAMA (1930)

The incidence of puerperal sepsis has shown but a moderate decrease the past few years. Even today its frequency is appalling and justifies the tremendous volume of censure to which the American medical profession is now subjected.  During the past quarter of a century the surgical technic of delivery has shown definite improvement. The progress of labor is now largely determined by abdominal palpation; vaginal examinations are made with increasing care and only when a rectal examination will not furnish the desired information. But there still remains a degree of sepsis which is inconsistent with a normal physiologic process, constitutes a national peril and demands further research in contradistinction to the indifference of today.  Severe and even fatal infections can and do occur in spontaneous deliveries under ideal conditions when the patient has been in labor only the average length of time and presents no history of recent coitus, douches
STUDIES ON THE INTERACTION BETWEEN PHAGOCYTES AND TUBERCLE BACILLI
Authors: Hartmann Stähelin, Emanuel Suter, Manfred L. Karnovsky
Journal: The Journal of Experimental Medicine (1956)

As a basis for studies on the interaction of phagocytes and tubercle bacilli experiments were carried out to obtain information on some biochemical characteristics of exudate leucocytes from guinea pigs. It was found that total cellular phosphorus was the most suitable measure of protoplasm. Cell counts were less reliable because of unavoidable clumping in the suspension, and dry weight measurements were less specific when contamination with erythrocytes occurred. The utility of phosphorus measurements in this connection depends upon the fact that an erythrocyte contains only 4 per cent of the phosphorus present in a leucocyte. From measurements on mixed suspensions consisting of varying known proportions of polymorphonuclear and mononuclear leucocytes as determined by differential counting, it was possible to compute true values for these two cell types with respect to oxygen consumption and lactic acid production. Thus it was found that monocytes consumed considerably more oxygen and produced more lactate than polymorphonuclear leucocytes. From the data obtained it is suggested that differences in metabolic activity found when comparing cell suspensions obtained by the use of different irritants are due to different proportions of the two cell types. In particular, the effects of oxygen tension and pH on the activities of the cells were studied. It was found that decreasing the proportion of oxygen in the atmosphere from that of air to 1 per cent reduced oxygen consumption by about 80 per cent, whereas lactic acid production was increased by about 45 per cent. It was also found that decreasing the pH of the medium below pH 7.5 caused a considerable reduction in the respiration, lactate production, and viability of polymorphonuclear leucocytes. The monocytes proved less sensitive to similar changes in pH, especially with regard to lactic acid production and viability. Observations were made of oxygen consumption and lactate production during phagocytosis. During the hour following the addition of heat-killed tubercle bacilli to the phagocytes, the oxygen consumption of suspensions rich in polymorphonuclear leucocytes rose by 60 per cent, and that of suspensions rich in monocytes rose by nearly 100 per cent. Lactic acid production was unchanged during phagocytosis.
Identification of Ischemic Area of Left Ventricle by Visualization of <sup>43</sup> K Myocardial Deposition
Authors: ROBERT E. BOTTI, WILLIAM J. MACINTYRE, WALTER H. PRITCHARD
Journal: Circulation (1973)

A new method to determine myocardial blood distribution was used to study a patient with a recent large transmural anterior myocardial infarct. The method consisted of injecting 43 potassium into a peripheral arm vein and recording the radioactivity over the chest with a scintillation (Anger) camera. Elimination of noncardiac radioactivity in the analysis of data was accomplished by recording the rapid passage of injected 99m technetium through the heart. The cardiac deposition of the potassium was visualized by identifying the contour of the heart from the technetium scan. In this patient deposition of 43 potassium was markedly reduced in the septal region of the myocardium. This correlated well with the ischemic area suggested by coronary angiography, which demonstrated proximal occlusion of the left anterior descending coronary artery and absence of obstructive disease in the other coronary arteries. Intracoronary artery injection of 43 K gave confirmation of decreased deposition in the same area. This method should prove helpful in the study of certain clinical problems, such as the evaluation of the patency of coronary artery bypass grafts.
Post-thrombotic Inferior Vena Caval Obstruction: A Review of 24 Patients
Authors: B. T. Jackson, M. L. Thomas
Journal: BMJ (1970)

An analysis of the clinical features of 24 patients with post-thrombotic obstruction of the inferior vena cava demonstrated by phlebography showed that the possible precipitating cause was usually trivial and the onset was often associated with bed rest. The classical physical signs of bilateral leg swelling and dilated superficial abdominal wall collateral veins were often absent. In this series bilateral leg swelling was present in 42% and dilated collateral veins were present in half of the patients.A history of recurrent varicose veins and venous ulcers was common and must be taken as an indication for cavography. The presence or absence of proteinuria is no guide to the level of the caval obstruction. The value of inferior vena cavography in making an accurate diagnosis is emphasized.
Postcards from the edge
Authors: Sally L Read
Journal: BMJ (2005)

The idea of using postcards to reduce repetition of deliberate self harm is good, but it cannot be delivered to the entire population of those who self harm. We looked at the incidence of deliberate overdose in our population of homeless patients from 1999 to 2003. There were 177 episodes in 116 patients, out of a population of 1617. This translated to an incidence of 7.2%, higher than that in the general population. Taking an overdose, and other forms of self harm, are more common in homeless people, many of whom have multiple illness. Some can be followed up through support workers, while others remain chaotic and at risk. Postcards and text messages may help some to make contact, but others will remain uncontactable.
Enhanced phospholipase C activity in the cultured skin fibroblast obtained from patients with coronary spastic angina: possible role for enhanced vasoconstrictor response
Authors: Ken Okumura, Tomohiro Osanai, Takuo Kosugi, Hiroyuki Hanada, Hiroshi Ishizaka, Tomohisa Fukushi, Takaatsu Kamada, Takeshi Miura, Toru Hatayama, Takao Nakano, Yasuhiro Fujino, Yoshimi Homma
Journal: Journal of the American College of Cardiology (2000)
Electrocardiographic Artifact Caused by an Arteriovenous Fistula
Authors: Vincent A. Graziano
Journal: JAMA (1979)

<h3>To the Editor.—</h3> A variety of artifacts may produce ECG findings simulating cardiac arrhythmias. Alternating current may produce regular fibrillary deflections in the tracing baseline; muscular tremor in patients with Parkinson's disease, diaphragmatic flutter, or hiccoughs may produce findings simulating atrial flutter.<sup>1</sup>We have seen an ECG artifact produced by a subcutaneous arteriovenous fistula (AVF) in a patient receiving hemodialysis. <h3>Report of a Case.—</h3> A 68-year-old man with end-stage renal disease from chronic interstitial nephropathy had been receiving hemodialysis therapy for five years. Hemodialysis access was an AVF in his right arm. A previously constructed AVF in his left arm was patent but unused because of excessive tortuosity. At the end of a dialysis treatment, he complained of chest pain and palpitations. A standard ECG was performed. A rhythm strip in lead I showed an idioventricular rhythm (Fig 1). The left arm electrode had been placed over the unused
A CASE OF CHRONIC HOARSENESS (ULCERATIVE LARYNGITIS) SHOWING TUBERCULOSIS AND CANCER IN THE SAME LESION
Authors: Gabriel Tucker
Journal: JAMA (1931)

In laryngeal diseases every obtainable aid is necessary in order to make a correct differential diagnosis, for in disease of the larynx early correct diagnosis may mean saving the patient's larynx, and, in many instances, his life as well. Mirror examination alone will seldom give sufficient information for a correct opinion. A routine study should include a careful history, a complete general examination by a competent internist, and serologic studies to exclude syphilis. Roentgen examination of the chest and sputum examinations to exclude tuberculosis should be made. Roentgen study of the larynx and neck by Dr. H. K. Pancoast's technic will give definite information as to the location and extent of the laryngeal lesion, and may also show evidence of metastasis or extension of the disease beyond the larynx. Repeated mirror observation of the progress of the lesion should be made, and if it does not clear up promptly, direct
AML1/MTG8 oncogene suppression by small interfering RNAs supports myeloid differentiation of t(8;21)-positive leukemic cells
Authors: Olaf Heidenreich, Jürgen Krauter, Heidemarie Riehle, Philipp Hadwiger, Matthias John, Gerhard Heil, Hans-Peter Vornlocher, Alfred Nordheim
Journal: Blood (2003)
Mycobacterium tuberculosis-Driven Targeted Recalibration of Macrophage Lipid Homeostasis Promotes the Foamy Phenotype
Authors: Varshneya Singh, Shilpa Jamwal, Ritu Jain, Priyanka Verma, Rajesh Gokhale, Kanury V.S. Rao
Journal: Cell Host & Microbe (2012)
Effects of rosiglitazone and metformin treatment on apelin, visfatin, and ghrelin levels in patients with type 2 diabetes mellitus
Authors: Nikolaos P.E. Kadoglou, Hercules Tsanikidis, Alkistis Kapelouzou, Ioannis Vrabas, Ioulia Vitta, Panayotis E. Karayannacos, Christos D. Liapis, Nikolaos Sailer
Journal: Metabolism (2009)
A Study of Atrioventricular Conduction in Atrial Fibrillation and Flutter in Man Using His Bundle Recordings
Authors: SUN H. LAU, ANTHONY N. DAMATO, WALTER D. BERKOWITZ, ROBERT D. PATTON
Journal: Circulation (1969)

Seven patients with atrial fibrillation and six patients with atrial flutter were studied using the technic of His bundle recordings. All 13 patients received digitalis. In atrial fibrillation each QRS complex (except for premature ventricular beats) was preceded by a single His bundle deflection. Complete block distal to the His bundle was not observed. Thus, the zone of concealment could be localized to the region proximal to the His bundle. The clinical findings were confirmed in three animal experiments. In atrial flutter the nonconducted P waves were also blocked proximal to the His bundle. In atrial fibrillation aberrant ventricular beats were distinguished from premature ventricular beats by the presence of a preceding His deflection in the former and its absence in the latter.
von Willebrand factor mutation enhancing interaction with platelets in patients with normal multimeric structure.
Authors: L Holmberg, J A Dent, R Schneppenheim, U Budde, J Ware, Z M Ruggeri
Journal: Journal of Clinical Investigation (1993)

Variant von Willebrand disease designated as type I New York or type Malmö is characterized by enhanced ristocetin-induced platelet agglutination with normal von Willebrand factor multimeric distribution in plasma. We have studied four such patients belonging to three unrelated families and found in all of them a unique cytosine-to-thymine transition changing the codon for Pro503 (CCG) to Leu (CTG). In three patients the mutant allele also had a silent mutation in the codon for Ser500 (TCG-->TCA). Both nucleotide changes are present in the von Willebrand factor pseudogene; however, the characterization of distinctive markers where the gene and pseudogene differ, as well as the examination of amplified cDNA derived from platelet mRNA, confirmed that the abnormality occurs in the von Willebrand factor gene of the patients. Moreover, recombinant expression of the isolated glycoprotein Ib-binding domain of von Willebrand factor provided direct evidence that the Pro503-->Leu mutation is responsible for enhanced platelet reactivity to lower ristocetin concentrations. These results define a new structural element affecting the affinity of von Willebrand factor for glycoprotein Ib and establish the molecular basis of a variant form of von Willebrand disease.
Eosinophilic Granuloma of Gastro-intestinal Tract Caused by Herring Parasite Eustoma Rotundatum
Authors: B. S. Ashby, P. J. Appleton, I. Dawson
Journal: BMJ (1964)

For over 25 years sporadic reports have been appearing in the literature of cases of eosinophilic granuloma arising in various parts of the gastro-intestinal tract.Kaiiser (1937) described the first cases.In a search of the literature, which although extensive is not claimed to be exhaustive, 47 papers were found, describing a total of 89 cases.They occurred throughout the alimentary tract from pharynx to rectum, though the majority were in the stomach and small intestine, and they