tbuckley/cabot-search huggingface dataset:
PTU-110 Circulating Bone Marrow-Derived Stem Cells and Stem Cell Factor Serum Level in Chronic Hepatitis C: Relation to Hepatic Proliferation and Fibrosis
Authors: H A El Aggan, N M Farahat, B M El Sabaa, A S Elyamany, R M Abou Esa
Journal: Gut (2013)

<h3>Introduction</h3> Bone marrow-derived stem cells (BMSCs) are pluripotent cells that can be mobilised into circulation and recruited to sites of inflammation where they promote local tissue repair. Therefore, the present work was designed to study circulating BM-derived hematopoietic stem cells (HSCs) and mesenchymal stem cells (MSCs) and serum levels of stem cell factor (SCF), a stem cell mobilising factor, in patients with chronic hepatitis C (CHC) in relation to hepatic proliferation and fibrosis. <h3>Methods</h3> Thirty treatment-naïve patients with CHC and 15 healthy subjects were included in the study. The BM-derived HSCs and MSCs cells in fresh blood samples were identified as CD34+CD45+CD117+ and CD34-CD45-CD106+ cells respectively using flow cytometric assay. Serum SCF levels were measured using an enzyme linked immunosorbant assaykit. Liver biopsies were examined to assess METAVIR histological activity grade and fibrosis stage and steatosis grade. Immunohistochemical staining of liver specimens was done using monoclonal antibodies against cytokeratin (CK)7 for detection of hepatic progenitor cells (HPCs), Ki-67 as proliferation marker and a-smooth muscle actin (a-SMA) for identification of activated hepatic stellate cells (HpSCs). <h3>Results</h3> Patients with CHC showed significant increases in the percentages of HSCs and MSCs in peripheral blood and serum SCF levels compared with healthy subjects (<i>P</i> &lt; 0.05). Numerous CK7+ HPCs were detected mostly lining primitive bile ducts or as individual positive cells in the portal tracts. Hepatic proliferative activity evidenced as nuclear positivity for Ki-67, was observed in proliferated ductal profiles in portal tracts and within hepatocytes and directly correlated with HPC expansion. Based on the percentages of BMSCs in peripheral blood, patients with CHC were distinguished into two types of patients: “mobilizers” and “non-mobilizers”. BMSC mobilizers showed a significant increase in serum SCF levels and significant decreases in HPC expansion, hepatic proliferative activity, serum levels of aminotransferases, histological activity grade, fibrosis stage and a-SMA expression compared with BMSC non-mobilizers (<i>P</i> &lt; 0.01). <h3>Conclusion</h3> Chronic HCV infection is associated with mobilisation of BMSCs from the BM into the circulation in parallel with an increased production of SCF, particularly when HPC activation and hepatic proliferative activity are impaired. Although the mobilised BMSCs are not sufficient to bring about hepatic repopulation, they may play an important role in limiting hepatic necroinflammation and fibrosis in HCV-induced liver damage. <h3>Disclosure of Interest</h3> None Declared
Organotin compounds: industrial applications and biological investigation.
Authors: W T Piver
Journal: Environmental Health Perspectives (1973)

Industial Uses of Organobn CompoundsAccording to Ross (1), there are three main areas in which organotin compounds have product and process utility: (1) heat stabilizers; (2) catalytic agents; (3) biocidal compounds.Organotin derivatives account for the fourth largest production of organo- metallics amounting to about 3-4 million pounds per year as compared with about 485 million pounds per year for organolead com- pounds.Originally, organotin compounds were developed as thermal stabilizers for chlorinated hydrocarbons which would be used in those applications for which there was a strong possibility of thermal degradation.However, as the chemistry of organotin com- pounds became better understood, their application expanded to catalytic and biologically active agents. Heat StabilizersOrganotin stabilizers prevent the thermal degradation of many chlorinated compounds such as certain types of transformer oils, PVC, poly(vinylidene chloride), chlorinated rubbers, paraffins, and modified plastics.The organotins have also been used to stabilize
THE VALUE OF CARBOLIZED WATER FOR THE PREVENTION OF SHOCK IN LITHOLOPAXY, WITH THE RESULTS OF NINETEEN CASES.
Authors: EDMUND ANDREWS
Journal: JAMA (1884)

Presented to the Section of Surgery and Anatomy of American Medical Association, May, 1884. The power of carbolic acid to benumb the sensibility of the nerves, when applied locally, is well known. For several years I have acted on this hint in the new operation of litholopaxy, with the view of blunting the impressibility of the urethral and vesical nerves, so as to make them tolerate the prolonged use of instruments without shock. For this purpose I provide a large supply of warm carbolized water, of the strength of from 1½ to 2 per cent., and use this exclusively, both to distend the bladder during the crushing of the stone and to wash out the fragments. The result is so gratifying that I cannot but attach great value to this method. I have tried it in nineteen cases, with only one death. The patients averaged nearly 60 years of age
POLIOMYELITIS IN THE CYNOMOLGUS MONKEY
Authors: Harold K. Faber, Rosalie J. Silverberg, Luther Dong
Journal: The Journal of Experimental Medicine (1948)

36 exposures of the stomach and intestines of 18 cynomolgus monkeys to large doses of poliomyelitis virus by a method designed to avoid simultaneous exposure of the oropharynx and upper esophagus induced poliomyelitis in only one instance. These observations are to be compared with a previous study in which exposures of the entire alimentary tract including oropharynx and upper esophagus by simple feeding of comparable amounts of the same strain resulted in poliomyelitis in half of the test animals. In the capsule-fed animals virus regularly appeared in the stools during and immediately after the feeding periods but disappeared thereafter excepting in the single case of poliomyelitis, in which it persisted. No evidence of resistance to subsequent intracerebral inoculation was observed in the uninfected capsule-fed animals.
CARDIOVASCULAR LESIONS AND CHANGES IN BLOOD COAGULATION AND FIBRINOLYSIS ASSOCIATED WITH DIET-INDUCED LIPEMIA IN THE RAT*
Authors: Shapur Naimi, Robert Goldstein, Martin M. Nothman, George F. Wilgram, Samuel Proger
Journal: Journal of Clinical Investigation (1962)

Among the animals in which atherosclerosis has been experimentally induced, the rat has been the object of particular interest because of its omnivorous dietary habits (1).In 1956, Fillios, Andrus, Mann and Stare (2) reported induction of atherosclerosis in this animal, using a diet that included cholesterol, sodium cholate, and thioura- cil.Yet in these and subsequent experiments by other investigators, vascular thrombosis, generally considered a secondary complication of athero- sclerosis, was noticeably rare (3).In 1959, Hartroft, O'Neal and Thomas (4, 5) added large amounts of butter to the basic diet used by Fillios and co-workers and reported a high percentage of thrombosis and myocardial infarction.They especially noted that thrombotic lesions may de- velop without accompanying vascular changes, and they reported that a number of these thrombi were found in cardiac chambers.Many have questioned the significance of such lesions devel- oped under severe experimental conditions.More recently, Gresham and Howard (6) re- ported confirmation of the experiments of Hart- roft and associates.It appeared that these ex- periments might provide a suitable model to appraise the still controversial connection between lipemia and clotting changes in vitro as well as the relevance of all this to the mechanism of thrombosis in vivo.
Prescriber Education on Opioids
Authors: James Webster
Journal: Annals of Internal Medicine (2012)

Letters18 December 2012Prescriber Education on OpioidsJames Webster, MD, MSJames Webster, MD, MSFrom Feinberg School of Medicine, Northwestern University, Chicago, IL 60611.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-157-12-201212180-00018 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:Becker and Fiellin (1) make pitch-perfect points. However, more issues must be addressed if the epidemic of deaths from opioid overdose is to be eradicated. Specifically, when there are more “pain clinics” than McDonald's franchises in Florida (2) and when 13% of primary care physicians say that they would stop prescribing these drugs if they had to take 4 to 8 hours of continuing medical education on that topic (3), we have problems.The profession should insist that local and federal law enforcement agencies aggressively shut down the “pill mills” and prosecute the unethical physicians who are ...References1. Becker WC, Fiellin DA. Federal plan for prescriber education on opioids misses opportunities. Ann Intern Med. 2012;157:205-6. [PMID: 22868838] LinkGoogle Scholar2. George M. ABC Action News. Investigation: Florida has more pain clinics than McDonald's, Burger Kings. 1 March 2011. Accessed at www.abcactionnews.com/dpp/news/region_tampa/investigation%3A-florida-has-more-pain-clinics-than-mcdonald's on 11 August 2012. Google Scholar3. Slevin KA, Ashburn MA. Primary care physician opinion survey on FDA opioid risk evaluation and mitigation strategies. J Opioid Manag. 2011;7:109-15. [PMID: 21561034] CrossrefMedlineGoogle Scholar4. Centers for Disease Control and Prevention (CDC). CDC grand rounds: prescription drug overdoses—a U.S. epidemic. MMWR Morb Mortal Wkly Rep. 2012;61:10-3. [PMID: 22237030] MedlineGoogle Scholar Author, Article, and Disclosure InformationAuthors: James Webster, MD, MSAffiliations: From Feinberg School of Medicine, Northwestern University, Chicago, IL 60611.Disclosures: None disclosed. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoFederal Plan for Prescriber Education on Opioids Misses Opportunities William C. Becker and David A. Fiellin Prescriber Education on Opioids William C. Becker and David A. Fiellin Metrics 18 December 2012Volume 157, Issue 12Page: 917KeywordsAddictsConflicts of interestDatabasesDrugsHomicideMedical educationOpioidsPrimary care physicians ePublished: 18 December 2012 Issue Published: 18 December 2012 Copyright & PermissionsCopyright © 2012 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
GENDER DIFFERENCES IN PRESENTATION AND LONG-TERM OUTCOMES BY TYPE OF AORTIC DISSECTION IN A LARGE COMMUNITY BASED COHORT
Authors: Armen Chalian, Ryan Clare, Keith Thompson, Albert Shen, Steven Khan, Michael Jorgensen, Vicken Aharonian, George Vatakencherry, Ramin Shadman, Ajay Kirtane, Somjot Brar
Journal: Journal of the American College of Cardiology (2014)
Fine-Tuning Therapy for Acute Coronary Syndromes
Authors: Valentin Fuster
Journal: New England Journal of Medicine (2010)

Aspirin and clopidogrel are mainstays of therapy for patients presenting with an acute coronary syndrome. National guidelines dictate that at the time of the patient's presentation to an emergency department, these therapies should be given expeditiously, whether or not percutaneous coronary intervention is planned. In this issue of the Journal, Mehta et al. report on the results of the Clopidogrel and Aspirin Optimal Dose Usage to Reduce Recurrent Events–Seventh Organization to Assess Strategies in Ischemic Syndromes (CURRENT–OASIS 7) trial, which evaluated alternative dosing regimens for both of these agents.1 In this trial, in contrast to other recent acute coronary syndrome . . .
An Allegory of the 1960 Presidential Election
Authors: M. Therese Southgate
Journal: JAMA (2006)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Affirmative Action and Other Special Consideration Admissions at the University of California, Davis, School of Medicine
Authors: Robert C. Davidson
Journal: JAMA (1997)

The use of race as a criterion for admission to medical schools and other professional schools has become increasingly controversial. This study documents the experience of students at one medical school, admitted through a special admissions process that included race as one consideration.To examine the medical school, postgraduate training, and career experiences of students admitted by a special consideration admission program that included traditional affirmative action admissions.Twenty-year, retrospective, matched-cohort study.A public medical school.All affirmative action and other special consideration admissions between 1968 and 1987 (20 years).Academic progress, national board examination scores, graduation, residency evaluations, and practice characteristics.During the study period, 20% of students were special consideration admissions (range, 10%-45% per year). Of special consideration admissions, 53.5% were minority students, while 19% of regular admissions were minority students. When only underrepresented minority groups are analyzed, 42.7% of special consideration admissions and 4.0% of regular admissions were minorities. Of special consideration admissions, 94% graduated vs 97% of regular admissions. Regular admission students were more likely to receive honors or an A grade on core basic and clinical science courses. There was no difference in failure rates of core courses. Regular admission students had higher scores on Parts I and II of the National Board of Medical Examiners examination, and special consideration students were more likely to repeat the examination to receive a passing grade. Following graduation, the experience of the special consideration admission students was very similar to that of regular admission students. There was no difference in completion of residency training or evaluation of performance by residency directors. Both populations selected primary care disciplines at the same rate. The practice characteristics of the 2 populations were remarkably similar.Criteria other than undergraduate grade point average and Medical College Admission Test scores can be used in predicting success in medical school. An admissions process that allows for ethnicity and other special characteristics to be used heavily in admission decisions yields powerful effects on the diversity of the student population and shows no evidence of diluting the quality of the graduates.
Dietary Fat in Relation to Prognostic Indicators in Breast Cancer
Authors: R. Verreault, J. Brisson, L. Deschenes, F. Naud, F. Meyer, L. Belanger
Journal: JNCI Journal of the National Cancer Institute (1988)

Journal Article Dietary Fat in Relation to Prognostic Indicators in Breast Cancer Get access René Verreault, René Verreault 3Epidemiology Research Unit, Department of Social and Preventive Medicine, Lava1 UniversitySte-Foy, Qutbéc, QC, Canada GlK 7P4 Search for other works by this author on: Oxford Academic PubMed Google Scholar Jacques Brisson, Jacques Brisson 3Epidemiology Research Unit, Department of Social and Preventive Medicine, Lava1 UniversitySte-Foy, Qutbéc, QC, Canada GlK 7P4 Search for other works by this author on: Oxford Academic PubMed Google Scholar Luc Deschěnes, Luc Deschěnes 4Department of Surgery, St-Sacrement HospitalQuébec city, Canada Search for other works by this author on: Oxford Academic PubMed Google Scholar Françoise Naud, Françoise Naud 5Department of Pathology, St-Françoise D'Assise HospitalQuébec, QC, Canada Search for other works by this author on: Oxford Academic PubMed Google Scholar François Meyer, François Meyer 3Epidemiology Research Unit, Department of Social and Preventive Medicine, Lava1 UniversitySte-Foy, Qutbéc, QC, Canada GlK 7P4 Search for other works by this author on: Oxford Academic PubMed Google Scholar Luc Bélanger Luc Bélanger 6Tancer Research Center, Hôtel-Dieu de QuébecQutbéc, QC, Canada Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 80, Issue 11, 3 August 1988, Pages 819–825, https://doi.org/10.1093/jnci/80.11.819 Published: 03 August 1988 Article history Received: 27 January 1988 Revision received: 01 April 1988 Accepted: 01 April 1988 Published: 03 August 1988
Cold doesn't affect the "common cold" in study of rhinovirus infections
Authors: R. C. Douglas
Journal: JAMA (1967)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Why Permanent Pacemaker Implantation After Transcatheter Aortic Valve Implantation Does Not Affect Long-Term Clinical Outcome
Authors: Patrick Houthuizen, Robert M.A. van der Boon, Leen A.F.M. Van Garsse, Frits W. Prinzen, Peter de Jaegere
Journal: Journal of the American College of Cardiology (2012)
ACCF Proposed Method for Evaluating the Appropriateness of Cardiovascular Imaging
Authors: Manesh R. Patel, John A. Spertus, Ralph G. Brindis, Robert C. Hendel, Pamela S. Douglas, Eric D. Peterson, Michael J. Wolk, Joseph M. Allen, Ira E. Raskin
Journal: Journal of the American College of Cardiology (2005)
The Physician and the Hospital Accreditation Program
Authors: Charles Dickerman
Journal: New England Journal of Medicine (1954)

THE hospital administrator has been given a burden in the form of added duties to keep his medical staff busy writing records and holding consultations so that the hospital may retain its rating. Many physicians think that all this extra paperwork takes much valuable time that could be used to better advantage. Thus, the administration and the medical staff need to understand one another on this important matter.Few physicians have any knowledge of hospital organization. They have no interest in the functions and the power of the governing board of the hospital, which approves the appointments to the medical . . .
Relation between stillbirth and specific chlorination by-products in public water supplies.
Authors: W D King, L Dodds, A C Allen
Journal: Environmental Health Perspectives (2000)

During water treatment, chlorine reacts with naturally occurring organic matter in surface water to produce a number of by-products. Of the by-products formed, trihalomethanes (THMs) are among the highest in concentration. We conducted a retrospective cohort study to evaluate the relationship between the level of total THM and specific THMs in public water supplies and risk for stillbirth. The cohort was assembled from a population-based perinatal database in the Canadian province of Nova Scotia and consisted of almost 50,000 singleton deliveries between 1988 and 1995. Individual exposures were assigned by linking mother's residence at the time of delivery to the levels of specific THMs monitored in public water supplies. Analysis was conducted for all stillbirths and for cause-of-death categories based on the physiologic process responsible for the fetal death. Total THMs and the specific THMs were each associated with increased stillbirth risk. The strongest association was observed for bromodichloromethane exposure, where risk doubled for those exposed to a level of [greater and equal to] 20 microg/L compared to those exposed to a level < 5 microg/L (relative risk = 1. 98, 95% confidence interval, 1.23-3.49). Relative risk estimates associated with THM exposures were larger for asphyxia-related deaths than for unexplained deaths or for stillbirths overall. These findings suggest a need to consider specific chlorination by-products in relation to stillbirth risk, in particular bromodichloromethane and other by-product correlates. The finding of a stronger effect for asphyxia deaths requires confirmation and research into possible mechanisms.
Drug company employee who queried trial wins appeal
Authors: T. Sheldon
Journal: BMJ (2003)

A former medical research manager in a drug company has won his appeal against a claim for damages awarded against him after he took his concerns about the doses of a drug in a trial to medical ethics committees without informing his employers.



Dr Koos Stiekema has won an appeal over damages



Dr Koos Stiekema had been found guilty of breaching obligations of confidentiality to the Dutch pharmaceutical giant Organon, causing the company “considerable financial disadvantage.” But the Amsterdam appeal court has ruled that Dr Stiekema faced a “conflict of duties” …