SYSTEMIC LUPUS ERYTHEMATOSUS PRECEDED BY FALSE-POSITIVE SEROLOGIC TESTS FOR SYPHILIS: PRESENTATION OF FIVE CASES
Authors: John R. Haserick, Roland Long
Journal: Annals of Internal Medicine (1952)

Article1 September 1952SYSTEMIC LUPUS ERYTHEMATOSUS PRECEDED BY FALSE-POSITIVE SEROLOGIC TESTS FOR SYPHILIS: PRESENTATION OF FIVE CASESJOHN R. HASERICK, M.D., ROLAND LONGJOHN R. HASERICK, M.D., ROLAND LONGAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-37-3-559 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptBiologic false-positive serologic tests for syphilis have frequently been observed in patients with all types of lupus erythematosus.1-6 The time relationship between the development of these serologic alterations and the onset of clinical manifestations of lupus erythematosus is unknown. We have been unable to find reports of cases in which false-positive tests for syphilis were observed prior to the clinical manifestations of lupus erythematosus (L. E.).The purpose of this communication is to report five cases in which false-positive serologic tests for syphilis were observed before the onset of clinical manifestations of systemic (positive plasma L. E. test7, 11) lupus...Bibliography1. White CJ: The problem of positive serologic tests for syphilis in lupus erythematosus, Am. J. Syph., Gonor. and Ven. Dis. 31: 235, 1947. MedlineGoogle Scholar2. Keil H: Dermatomyositis and systemic lupus erythematosus, Arch. Int. Med. 66: 339, 1940. CrossrefGoogle Scholar3. Gennerich , cited by Keil.2 Google Scholar4. CoburnMoore AFDH: The plasma proteins in disseminated lupus erythematosus, Bull. Johns Hopkins Hosp. 73: 196 (Sept.) 1943. Google Scholar5. MontgomeryMcCreight HWG: Disseminate lupus erythematosus, Arch. Dermat. and Syph. 60: 356 (Sept.) 1949. CrossrefGoogle Scholar6. ReinKostant CRGH: Lupus erythematosus: serologic and chemical aspects, Arch. Dermat. and Syph. 61: 898 (June) 1950. CrossrefGoogle Scholar7. HaserickBortz JRDW: New diagnostic test for acute disseminated lupus erythematosus, Cleveland Clin. Quart. 16: 158, 1949. CrossrefGoogle Scholar8. HaserickLewisBortz JRLADW: Blood factor in acute disseminated lupus erythematosus. I. Determination of gamma globulin as specific protein fraction, Am. J. M. Sc. 219: 660, 1950. CrossrefMedlineGoogle Scholar9. HaserickLewis JRLA: Blood factor in acute disseminated lupus erythematosus. II. Induction of specific antibodies against L. E. factor, Blood 5: 718, 1950. CrossrefMedlineGoogle Scholar10. HargravesRichmondMorton MMHR: Presentation of two bone marrow elements: "tart cell and L. E. cell," Proc. Staff Meet., Mayo Clin. 23: 25, 1948. MedlineGoogle Scholar11. HaserickBortz JRDW: Normal bone marrow inclusion phenomenon induced by lupus erythematosus plasma, J. Invest. Dermat. 13: 47, 1949. CrossrefMedlineGoogle Scholar12. Moore JE: The modern treatment of syphilis, 2nd Ed., 1944, Chas. C Thomas, Springfield, Illinois. Google Scholar13. Haserick JR: Plasma L. E. test in systemic lupus erythematosus: study of 23 patients with positive tests, J. A. M. A. 146: 16 (May 5) 1951. CrossrefMedlineGoogle Scholar14. Hargraves MM: Symposium on lupus erythematosus, Univ. of Minnesota, Minneapolis, April 5-6, 1951. Google Scholar15. Soffer LJ: Symposium on lupus erythematosus, Univ. of Minnesota, Minneapolis, April 5-6, 1951. Google Scholar16. RussellHaserickZucker PJREM: Epilepsy in systemic lupus erythematosus, Arch. Int. Med. 88: 78-92 (July) 1951. CrossrefGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: *Presented at Midwest Regional Meeting of American College of Physicians in Columbus, Ohio, on October 13, 1951. Received for publication October 17, 1951.From the Cleveland Clinic and The Frank E. Bunts Educational Institute, Department of Dermatology, Earl W. Netherton, M.D., Chief.This investigation was made possible in part by a research grant from the National Institutes of Health, United States Public Health Service. 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CELL TEST ON THE CLINICAL PICTURE OF SYSTEMIC LUPUS ERYTHEMATOSUS*EDMUND L. DUBOIS, M.D. 1 September 1952Volume 37, Issue 3Page: 559-565KeywordsBiologicsBlood plasmaDermatologyLupus erythematosusMedical servicesPrevention, policy, and public healthResearch grantsSyphilis ePublished: 1 December 2008 Issue Published: 1 September 1952 PDF downloadLoading ...