EFFECT OF OXALIC ACID INTRAVENOUSLY ON BLOOD-COAGULATION TIME IN THREE HEMOPHILIACS
Authors: R. C. Page, H. K. Russell, R. L. Rosenthal
Journal: Annals of Internal Medicine (1940)

Article1 July 1940EFFECT OF OXALIC ACID INTRAVENOUSLY ON BLOOD-COAGULATION TIME IN THREE HEMOPHILIACSR. C. PAGE, M.D., H. K. RUSSELL, M.D., R. L. ROSENTHAL, M.D.R. C. PAGE, M.D.Search for more papers by this author, H. K. RUSSELL, M.D.Search for more papers by this author, R. L. ROSENTHAL, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-14-1-78 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe present conception of hemophilia1 is that it is a constitutional disease characterized by prolonged hemorrhage, due to increased coagulation time. There is an inherited, sex-linked defect in the clotting mechanism. The typical finding is an increased coagulation time, which apparently results from a deficient supply of thromboplastin, which is in turn due to an abnormal resistance of the platelets to disintegration.Quick2states that if thromboplastin is added, hemophilic blood will coagulate as rapidly as normal blood. This indicates that a deficiency of thromboplastin is the probable cause of the defective clotting, and that it is probably the slow...Bibliography1. HADEN RL: Principles of hematology, 1939, Lea and Febiger, Philadelphia, p. 167. Google Scholar2. QUICK AJ: The clotting time of hemophilic blood, Jr. Am. Med. Assoc., 1939, cxii, 879. Google Scholar3. BIRCH CF: Discussion of QUICK, A. J.: Ibid. Google Scholar4. HOWELL WH: Hemophilia, Bull. New York Acad. Med., 1939, xv, 3-26. Google Scholar5. PATEKTAYLOR AJFH: Hemophilia, Jr. Clin. Invest., 1937, xvi, 113-124. CrossrefGoogle Scholar6. PAGETHOMAS RCEG: Local application of Russell viper venom for the control of hemorrhage, Med. Clin. North Am., 1940, xxiv, 777-789. CrossrefGoogle Scholar7. TIMPERLEYNAISHCLARK WAAEGA: New method of treatment in haemophilia, Lancet, 1936, ii, 1142-1149. CrossrefGoogle Scholar8. LOZNERTAYLOR ELFH: The coagulation defect in hemophilia, Jr. Clin. Invest, 1939, xviii, 821-825. CrossrefGoogle Scholar9. STEINBERGBROWN SWR: A new concept regarding the mechanism of clotting and the control of hemorrhage, Am. Jr. Physiol., 1939, cxxvi, 638. Google Scholar10. SCHUMANN EA: Newer concepts of blood coagulation and the control of hemorrhage, Am. Jr. Obst. and Gynec. 1939, xxxviii, 1002-1005. CrossrefGoogle Scholar11. SOLLMANN T: A manual of pharmacology (4th Ed.), 1934, W. B. Saunders Co., Philadelphia, p. 896. Google Scholar12. BROCKDRUCKREYHERKEN NHH: Oxalatwirkung und Calcium, Schmiedeberg's Arch. f. exper. Path. u. Pharmakol., 1940, cxciv, 165-173. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: New York*Received for publication April 13, 1940.From the Hematologic Service, Grasslands Hospital, Valhalla, New York.†9 E. 41st St., New York, N. Y. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited by“Whatever Works”: Innovations in the Treatment of Hemophilia in the United States 1783–1950The Diphasic Actions of Ceanothyn and EDTA as Blood Coagulants**Department of Physiology, School of Medicine, Indiana University, Bloomington, Ind.Control of hemorrhage—or transfusionDie Therapie der hämorrhagischen DiathesenSHEPHERD'S PURSE AND HÆMOPHILIARESEARCH AT THE ROYAL CANCER HOSPITALCONVULSIONS ON WITHDRAWAL OF DRUGS 1 July 1940Volume 14, Issue 1Page: 78-86KeywordsBloodHemorrhagePlatelets ePublished: 1 December 2008 Issue Published: 1 July 1940 PDF downloadLoading ...