Plasma Triglyceride and Insulin Levels in Familial Hypertriglyceridemia
Authors: JOHN D. BRUNZELL
Journal: Annals of Internal Medicine (1977)

Brief Reports1 August 1977Plasma Triglyceride and Insulin Levels in Familial HypertriglyceridemiaJOHN D. BRUNZELL, M.D., F.A.C.P., EDWIN L. BIERMAN, M.D., F.A.C.P.JOHN D. BRUNZELL, M.D., F.A.C.P.Search for more papers by this author, EDWIN L. BIERMAN, M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-87-2-198 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptPlasma triglyceride levels have been correlated with insulin levels in both normal populations and in patients with endogenous hypertriglyceridemia (1). As a result of this reproducible significant association, it has been suggested that hyperinsulinism might be causally related to endogenous hypertriglyceridemia (2).It has now been established that "endogenous hypertriglyceridemia" describes a heterogenous group of primary familial and sporadic disorders. Recently two common forms of monogenic hypertriglyceridemia have been described: "pure" monogenic familial hypertriglyceridemia, in which the hypertriglyceridemic propositus comes from a family in which all affected relatives have isolated hypertriglyceridemia; and familial combined hyperlipidemia, in which the hypertriglyceridemic propositus...References1. BIERMANPORTEBAGDADE EDJ: Hypertriglyceridemia and glucose intolerance in man, in Adipose Tissue, Regulation and Metabolic Functions, edited by JEANRENAUD B, HEPP D. New York, Academic Press, 1970, p. 209 Google Scholar2. OLEFSKYREAVENFARQUHAR JGJ: Effects of weight reduction on obesity. J Clin Invest 53:64-76, 1974 CrossrefMedlineGoogle Scholar3. GOLDSTEINSCHROTTHAZZARDBIERMANMOTULSKY JHWEA: Hyperlipidemia in coronary heart disease. J Clin Invest 52:1544-1568, 1973 CrossrefMedlineGoogle Scholar4. MAYES P: Studies on the major pathways of hepatic lipid metabolism using the perfused liver, in Adipose Tissue, Regulation and Metabolic Functions, edited by JEANRENAUD B, HEPP D. New York, Academic Press, 1970, pp. 186-192 Google Scholar5. PYKÄLISTÖSMITHBRUNZELL OPJ: Determinants of human adipose tissue lipoprotein lipase. Effect of diabetes and obesity on basal-and diet-induced activity. J Clin Invest 56:1108-1117, 1975 CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: JOHN D. BRUNZELL, M.D., F.A.C.P.; EDWIN L. BIERMAN, M.D., F.A.C.P.Affiliations: Division of Metabolism, Endocrinology, and Gerontology Department of Medicine University of Washington Seattle, WA 98195 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byA study of insulin resistance using the minimal model in nondiabetic familial combined hyperlipidemic patientsProfactor-H (elevated circulating insulin): The link to health risk factors and diseases of civilizationRelations of plasma TG and HDL-C concentrations to body composition and plasma insulin levels are altered in men with small LDL particles.Insulin and AtherosclerosisAcquired Hyperlipidemia (Secondary Dyslipoproteinemias)Hormonal and Metabolic Profiles in Patients with alcohol-induced, mixed hypertriglyceridemia before and after abstinence from ethanol and before and after a lipid-lowering dietDiminished insulin receptors on monocytes and erythrocytes in hypertriglyceridemiaTreatment of common lipoprotein disordersHormonal regulation of lipogenesis in human diploid fibroblasts from normal subjects and from patients with familial hypertriglyceridaemiaSevere hypertriglyceridemia: Role of familial and acquired disordersPlasma lipoproteins in familial combined hyperlipidemia and monogenic familial hypertriglyceridemiaFamilial Hypertriglyceridemia: Incidence, Genetics and Possible Defect in Cellular MetabolismTreatment of Hyperlipidemic Pancreatitis in Pregnancy With Total Parenteral NutritionChylomicronemia Syndrome: Interaction of Genetic and Acquired HypertriglyceridemiaLipid metabolism in diabetesVery Low Density Lipoprotein Kinetics in Familial Forms of HypertriglyceridemiaEndogenous hypertriglyceridemia: A splanchnic defect, hyperinsulinism, or both?Hormonal and substrate responses to a standard meal in normal and hypertriglyceridemic subjectsAcetyl-CoA carboxylase activity in cultured human fibroblastsRelationship between insulin resistance, insulin secretion, very low density lipoprotein kinetics, and plasma triglyceride levels in normotriglyceridemic manStudied of very low density lipoprotein triglyceride metabolism in an obese population with low plasma lipids: lack of influence of body weight or plasma insulinVery low density lipoprotein overproduction in genetic forms of hypertriglyceridaemiaPostprandial adipose tissue lipoprotein lipase activity in primary hypertriglyceridemiaVery low density lipoprotein overproduction in genetic forms of hypertriglyceridaemiaLipoproteins in Nutrition and TransportPathophysiology of lipoprotein transport 1 August 1977Volume 87, Issue 2Page: 198-199KeywordsBlood plasmaHyperinsulinemiaHyperlipidemiaInsulinPopulation statistics ePublished: 1 December 2008 Issue Published: 1 August 1977 PDF downloadLoading ...