tbuckley/cabot-search huggingface dataset:
Effects of inotropic and chronotropic stimuli on acute myocardial ischemic injury. I. Studies with dobutamine in the anesthetized dog.
Authors: R E Rude, C Izquierdo, L M Buja, J T Willerson
Journal: Circulation (1982)

The effect of i.v. dobutamine on acute myocardial ischemic injury was assessed in 22 anesthetized dogs subjected to serial 10-minute occlusions of the left anterior descending coronary artery. The severity of ischemic injury was determined by mass spectrometric measurement of the increase in intramural carbon dioxide tension (delta PmCO2) in the ischemic zone. In the time protocol 1 dogs, dobutamine, 20 micrograms/kg/min, infused between the control and final occlusion, significantly increased both heart rate (HR) and left ventricular (LV) dP/dt; delta PmCO2 was significantly higher during the dobutamine infusion that during control occlusion (76 +/- 21 vs 56 +/- 13 mm Hg, p less than 0.01). The nine protocol 2 dogs were atrially paced at a HR of 20--30 beats/min above baseline values during the control occlusion and received dobutamine (12.6 +/- 7.8 micrograms/kg/min) at doses necessary to attain an equal HR (mean 149--154 beats/min) during the last occlusion. Although LV dP/dt was higher after dobutamine, delta PmCO2 was similar during the two occlusions. Protocol 3 dogs (n = 4) received lower doses of dobutamine (5.6 +/- 3.2 micrograms/kg/min) to produce an increase in LV dP/dt, but not in HR compared with baseline values; delta PmCO2 was similar during control and dobutamine occlusions. There were no major change in arterial or left atrial pressures. Rate-pressure product, an indirect measurement of myocardial oxygen consumption, was increased only by the higher doses of dobutamine in protocol 1. Thus, inotropic stimulation with dobutamine during coronary occlusion does not cause important augmentation of acute myocardial ischemic injury in the nonfailing heart unless HR is increased simultaneously.
Mechanisms of and facility types involved in hazardous materials incidents.
Authors: S N Kales, G N Polyhronopoulos, M J Castro, R H Goldman, D C Christiani
Journal: Environmental Health Perspectives (1997)

The purpose of this study was to systematically investigate hazardous materials (hazmat) releases and determine the mechanisms of these accidents, and the industries/activities and chemicals involved. We analyzed responses by Massachusetts' six district hazmat teams from their inception through May 1996. Information from incident reports was extracted onto standard coding sheets. The majority of hazardous materials incidents were caused by spills, leaks, or escapes of hazardous materials (76%) and occurred at fixed facilities (80%). Transportation-related accidents accounted for 20% of incidents. Eleven percent of hazardous materials incidents were at schools or health care facilities. Petroleum-derived fuels were involved in over half of transportation-related accidents, and these accounted for the majority of petroleum fuel releases. Chlorine derivatives were involved in 18% of all accidents and were associated with a wide variety of facility types and activities. In conclusion, systematic study of hazardous materials incidents allows the identification of preventable causes of these incidents.
Vitamin B6 Deficiency In Beer Drinkers
Authors: Robert V. Edwards
Journal: JAMA (1966)

<h3>To the Editor:—</h3> Recent publicity (<b>196</b>, June 13, 1966, adv p 25;<b>197</b>: 592 [Aug 17] 1966; and<i>AMA News</i>Oct 17, 1966, p 4) emphasized the mystery surrounding unexplained myocarditis, heart failure, and death in heavy beer drinkers. Perhaps the mystery can be explained by vitamin B<sub>6</sub>deficiency rather than by some possible toxin such as cobaltous additives. French reported that myocardial necrosis was frequent in vitamin B<sub>6</sub>-deficient rats.<sup>1</sup>Assada and Mitsumori have shown a decrease in production of serum pyridoxal phosphate (the active biological form of vitamin B<sub>6</sub>) in humans who have liver disease.<sup>2</sup>Perhaps the heavy beer drinkers were alcoholics who were unable to manufacture sufficient pyridoxal phosphate because of vitamin B<sub>6</sub>deficiency and liver damage.
FcγRIIB regulates T-cell autoreactivity, ANCA production, and neutrophil activation to suppress anti-myeloperoxidase glomerulonephritis
Authors: Joshua D. Ooi, Poh-Yi Gan, Tong Chen, Peter J. Eggenhuizen, Janet Chang, Maliha A. Alikhan, Dragana Odobasic, Stephen R. Holdsworth, A. Richard Kitching
Journal: Kidney International (2014)
A Gray Pigmented Band of the Third Fingernail With Distal Splitting
Authors: Emi Dika, Bianca Maria Piraccini, Pier Alessandro Fanti
Journal: JAMA Dermatology (2013)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Dermatology HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Dermatology journal
Respiratory Failure in Polyradiculoneuritis Associated With Infectious Mononucleosis
Authors: Olga M. Eaton
Journal: JAMA (1965)

In a case of Guillain-Barré syndrome associated with infectious mononucleosis, the initial neurological manifestation was mild facial diplegia. However, motor failure, which progressed rapidly despite steroid administration, resulted in respiratory insufficiency. Ventilatory assistance was required to permit survival, which was followed by complete recovery. Early respiratory evaluation, close observation (including serial measurement of appropriate pulmonary factors), and individualized expert respiratory management are important. Such management should decrease substantially the high mortality from respiratory failure in patients with polyradiculoneuritis and should permit the complete recovery that is possible because the neuropathological lesion is usually reversible.
Genetic Research Provides Insights Into Age-Related Macular Degeneration
Authors: Tracy Hampton
Journal: JAMA (2010)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Effect of colouring green stage zirconia on the adhesion of veneering ceramics with different thermal expansion coefficients
Authors: Guliz Aktas, Erdal Sahin, Pekka Vallittu, Mutlu Özcan, Lippo Lassila
Journal: International Journal of Oral Science (2013)

This study evaluated the adhesion of zirconia core ceramics with their corresponding veneering ceramics, having different thermal expansion coefficients (TECs), when zirconia ceramics were coloured at green stage. Zirconia blocks (N=240; 6 mm×7 mm×7 mm) were manufactured from two materials namely, ICE Zirconia (Group 1) and Prettau Zirconia (Group 2). In their green stage, they were randomly divided into two groups. Half of the specimens were coloured with colouring liquid (shade A2). Three different veneering ceramics with different TEC (ICE Ceramic, GC Initial Zr and IPS e.max Ceram) were fired on both coloured and non-coloured zirconia cores. Specimens of high noble alloys (Esteticor Plus) veneered with ceramic (VM 13) (n=16) acted as the control group. Core–veneer interface of the specimens were subjected to shear force in the Universal Testing Machine (0.5 mm⋅min−1). Neither the zirconia core material (P=0.318) nor colouring (P=0.188) significantly affected the results (three-way analysis of variance, Tukey's test). But the results were significantly affected by the veneering ceramic (P=0.000). Control group exhibited significantly higher mean bond strength values (45.7±8) MPa than all other tested groups ((27.1±4.1)−(39.7±4.7) and (27.4±5.6)−(35.9±4.7) MPa with and without colouring, respectively) (P<0.001). While in zirconia–veneer test groups, predominantly mixed type of failures were observed with the veneering ceramic covering <1/3 of the substrate surface, in the metal–ceramic group, veneering ceramic was left adhered >1/3 of the metal surface. Colouring zirconia did not impair adhesion of veneering ceramic, but veneering ceramic had a significant influence on the core–veneer adhesion. Metal–ceramic adhesion was more reliable than all zirconia–veneer ceramics tested. Choosing the right combination of materials for false tooth cores and veneers could help to reduce chipping, research from Europe indicates. Zirconia ceramics are a popular alternative to metal cores in dental prosthetics because, once colored and veneered, they closely resemble natural enamel. However, chipping can occur in zirconia prosthetics after a short time. Güliz Aktas at Hacettepe University, Turkey, together with co-workers in Finland and Switzerland, analyzed the effect that the coloring of zirconia has on veneer bond strength. They also studied the different thermal expansion rates of the veneers and their adhesion to zirconia. Although coloring had no discernible effects, using a veneer with a different thermal expansion coefficient to that of the core weakened the bond between the two.
Spontaneous bacterial peritonitis in patients with cirrhosis undergoing selective intestinal decontamination
Authors: Josep M. Llovet, Pilar Rodríguez-Iglesias, Eduardo Mointinho, Ramón Planas, Ramón Bataller, Miquel Navasa, Marga Menacho, Albert Pardo, Antoni Castells, Eduard Cabré, Vicente Arroyo, Miquel Angel Gassull, Joan Rodés
Journal: Journal of Hepatology (1997)
Bacterial phospholipid hydrolysis enhances the destruction of Escherichia coli ingested by rabbit neutrophils. Role of cellular and extracellular phospholipases.
Authors: G C Wright, J Weiss, K S Kim, H Verheij, P Elsbach
Journal: Journal of Clinical Investigation (1990)

Escherichia coli ingested by PMN are promptly growth arrested but undergo limited destruction. We have studied bacterial phospholipid hydrolysis as a possible limiting factor in the disassembly of ingested E. coli, comparing the fates, during phagocytosis by rabbit peritoneal exudate PMN, of three isogenic strains, differing in their content of the pldA gene encoding the principal E. coli phospholipase A (PLA), i.e., pldA-, pldA+, pldA (the latter strain bearing the pldA gene in a multicopy plasmid resulting in a 20-fold increase in PLA content). Ingestion and growth inhibition (greater than 99% within 15 min) were the same for the three strains, but phospholipid degradation differed according to bacterial PLA content: pldA up to 60%, pldA+ up to 30%, and pldA- up to 20%. Since the pldA- strain has no activatable PLA, phospholipid degradation in this strain demonstrates the action of a PMN PLA. Added PLA2-rich ascitic fluid (AF) or purified AF PLA2 increased the rate and extent of degradation of the pldA- strain, provided the enzyme was added before ingestion was complete. 125I-AF-PLA2 binds to both E. coli and PMN and thus can enter the vacuole during phagocytosis. Although up to 50-fold more AF-PLA2 than the PLA2 content of the PMN could be loaded into the PMN in this way, degradation of pldA- E. coli did not exceed 30%. Increased phospholipid degradation had no effect on the degradation of bacterial macromolecules. In contrast, bacterial disassembly manifest as structural disorganization, release of bacterial protein derived material, and inhibition of protein synthesis were markedly enhanced when greater than 50% of prelabelled bacterial phospholipids were degraded. These findings reveal a link between envelope phospholipid degradation and overall bacterial destruction, suggesting therefore that factors limiting PLA action limit the destruction of E. coli ingested by PMN.
A COMPARISON OF HUMAN AND GUINEA PIG COMPLEMENTS AND THEIR COMPONENT FRACTIONS
Authors: Otto G. Bier, Graciela Leyton, Manfred M. Mayer, Michael Heidelberger
Journal: The Journal of Experimental Medicine (1945)

1. Defects in methods previously proposed for the estimation of complement components are: failure to ensure an excess of the desired components and failure to ensure absence of anticomplementary effects in the dilution ranges used. Existing data are therefore subject to these uncertainties. 2. Methods are proposed for controlling the adequacy of the reagent for each component, for using it in dilutions below its anticomplementary range, and for reinforcing it with necessary components if these are present in inadequate amounts. 3. Titrations are given of the four components in human and guinea pig complements and in "midpiece," "endpiece," and in the various reagents used, including one with C'3 reactivity, solely, and one withC'4 reactivity. 4. C'3 is shown to be the component which usually limits the titer in guinea pig complement, and C'2 the component of lowest titer in human complement. 5. In immune hemolysis, each component of human complement may be replaced by the corresponding component of guinea pig complement and vice versa.
Functional analysis of T cells expressing Ia antigens. I. Demonstration of helper T-cell heterogeneity.
Authors: J E Swierkosz, P Marrack, J W Kappler
Journal: The Journal of Experimental Medicine (1979)

We have examined the expression of I-region antigens on functional subpopulations of murine T cells. A.TH anti-A.TL (anti-Ik, Sk, Gk) alloantiserum was raised by immunization of recipients with concanavalin A (Con A) stimulated thymic and peripheral T-cell blasts. In contrast to similar antisera made by conventional methods, the anti-Ia blast serum was highly cytotoxic for purified T lymphocytes. Moreover, it reacted in a specific fashion with T cells having particular functions. Treatment of keyhole limpet hemocyanin (KLH)-primed B10.A (H-2 alpha) T cells with this antiserum plus complement resulted in the elimination of helper activity for B-cell responses to trinitrophenyl-KLH. Inhibition was shown to be a result of the selective killing of one type of helper T cell whose activity could be replaced by a factor(s) found in the supernate of Con A-activated spleen cells. A second type of helper cell required for responses to protein-bound antigens appeared to be Ia-. By absorption and analysis on H-2 recombinants, at least two specificities were detectable on helper T cells; one mapping in the I-A subregion and a second in a region(s) to the right of I-J. In addition, the helper T cell(s) involved in the generation of alloreactive cytotoxic lymphocytes was shown to be Ia+, whereas cytotoxic effector cells and their precursors were Ia- with this antiserum. These results provide strong evidence for the selective expression of I-region determinants on T-cell subsets and suggest that T-cell-associated Ia antigens may play an important role in T-lymphocyte function.
Successful treatment of chronic myeloid leukemia with imatinib mesylate in a patient with chronic renal failure on hemodialysis
Authors: Evren Ozdemir, Yener Koc, Emin Kansu
Journal: American Journal of Hematology (2006)

Induction Chemotherapy and Post-Remission Imatinib Therapy for de Novo BCR-ABL-Positive AMLTo the Editor: Translocation t(9;22)(q34;q11) is found in 1-2% of newly diagnosed patients with de novo AML.The prognosis of Ph þ AML is very poor with a median survival time of only 7 months.We present two patients with de novo Ph þ AML who received induction chemotherapy and post-remission imatinib therapy.A 73-year-old man was admitted in November 2003 with fatigue and palpitation.Physical examination showed only pallor.The Hb was 83 g/L, platelets 145 Â 10 9 /L, and WBC 1.4 Â 10 9 /L, 0.12 Â 10 9 /L blast cells.FACS analysis of marrow mononuclear cells showed 22% blast cells positive for HLA-DR, CD34, CD117, CD13, CD33, MPO, and CD38 and partially CD11b.Karyotype analysis of bone
Expression of c-jun is not mandatory for mouse hepatocyte proliferation induced by two nuclear receptor ligands: TCPOBOP and T3
Authors: Vera P. Leoni, Giovanna M. Ledda-Columbano, Monica Pibiri, Christian Saliba, Andrea Perra, Marta A. Kowalik, Oli M.V. Grober, Maria Ravo, Alessandro Weisz, Joseph Locker, Elena Ghiso, Silvia Giordano, Amedeo Columbano
Journal: Journal of Hepatology (2011)
They Say You're Crazy: How the World's Most Powerful Psychiatrists Decide Who's Normal
Authors: Carl C. Bell
Journal: JAMA (1995)

The main point of this book is to contest the use of self-defeating personality disorder (SDPD) and late luteal phase dysphoric disorder (LLPDD) as diagnoses for women. Dr Caplan, a psychologist, feels that women who are labeled with these diagnoses are going to be damaged by the intervention. Accordingly, she wants to expose the decisionmaking process about who is "normal," as she feels that being knowledgeable about this background can help persons overcome the damage done to them when they are called "abnormal." It is the author's opinion that the constructing of the<i>Diagnostic and Statistical Manual, Fourth Edition (DSM-IV)</i>, of the American Psychiatric Association (APA) was a "disingenuous and dishonest process." Dr Caplan underscores most people's concern with being classified as "normal," and she appropriately notes that being labeled mentally "abnormal" causes countless people to have a poor self-image. She feels mental health professionals tend to overdiagnose rather than
Innovative continuous non-invasive cuffless blood pressure monitoring based on photoplethysmography technology
Authors: Juan C. Ruiz-Rodríguez, Adolf Ruiz-Sanmartín, Vicent Ribas, Jesús Caballero, Alejandra García-Roche, Jordi Riera, Xavier Nuvials, Miriam de Nadal, Oriol de Sola-Morales, Joaquim Serra, Jordi Rello
Journal: Intensive Care Medicine (2013)
Tibolone reduced risk for fractures and breast cancer but increased risk for stroke in older women with osteoporosis
Authors: Robert P. Kauffman
Journal: Annals of Internal Medicine (2008)

ACP Journal ClubNovember 18, 2008Tibolone reduced risk for fractures and breast cancer but increased risk for stroke in older women with osteoporosisRobert P. Kauffman, MDRobert P. Kauffman, MDTexas Tech University School of Medicine, Amarillo, Texas, USA (R.P.K.)Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-149-10-200811180-02008 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail Source CitationCummings SR, Ettinger B, Delmas PD, et al. The effects of tibolone in older postmenopausal women. N Engl J Med. 2008;359:697-708. https://pubmed.ncbi.nlm.nih.gov/18703472Clinical Impact RatingsEndocrinology: Geriatrics: References1 Rossouw JE, Anderson GL, Prentice RL, et al. Risks and benefits of estrogen plus progestin in healthy postmenopausal women: principal results From the Women's Health Initiative randomized controlled trial. JAMA. 2002;288:321-33. [PMID: 12117397] Google Scholar2 Modelska K and Cummings S. Tibolone for postmenopausal women: systematic review of randomized trials. J Clin Endocrinol Metab. 2002;87:16-23. [PMID: 11788614] Google Scholar Author, Article, and Disclosure InformationAffiliations: Texas Tech University School of Medicine, Amarillo, Texas, USA (R.P.K.) PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics November 18, 2008Volume 149, Issue 10Page: JC5-8KeywordsBody mass indexBone densityBreast cancerCalciumColorectal cancerCoronary heart diseaseDrug administrationDrug therapyEndocrinologyEstrogensFoodGeriatricsHipOsteoporosisSafetySpineStrokeUltrasound imagingUterusVenous thromboembolism ePublished: 10 March 2020 Issue Published: November 18, 2008 Copyright & PermissionsCopyright © 2008 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Whole-genome sequencing for identification of Mendelian disorders in critically ill infants: a retrospective analysis of diagnostic and clinical findings
Authors: Laurel K Willig, Josh E Petrikin, Laurie D Smith, Carol J Saunders, Isabelle Thiffault, Neil A Miller, Sarah E Soden, Julie A Cakici, Suzanne M Herd, Greyson Twist, Aaron Noll, Mitchell Creed, Patria M Alba, Shannon L Carpenter, Mark A Clements, Ryan T Fischer, J Allyson Hays, Howard Kilbride, Ryan J McDonough, Jamie L Rosterman, Sarah L Tsai, Lee Zellmer, Emily G Farrow, Stephen F Kingsmore
Journal: The Lancet Respiratory Medicine (2015)
DNA hypermethylation at the D17S5 locus and reducedHIC-1mRNA expression are associated with hepatocarcinogenesis
Authors: Yae Kanai, Ai-Min Hui, Lin Sun, Saori Ushijima, Michiie Sakamoto, Hitoshi Tsuda, Setsuo Hirohashi
Journal: Hepatology (1999)

To examine the significance of aberrant DNA methylation in hepatocarcinogenesis, the DNA methylation status at the D17S5 locus and mRNA expression of a candidate tumor suppressor gene, HIC–1 (hypermethylated–in–cancer), which was identified at the D17S5 locus, in primary hepatocellular carcinomas (HCCs) and their corresponding noncancerous liver tissues were assessed. DNA hypermethylation at the D17S5 locus was detected in 44% of the noncancerous liver tissues showing chronic hepatitis or cirrhosis, which are widely considered to be precancerous conditions, but was not observed in noncancerous liver tissues showing no remarkable histological findings. The incidence of DNA hypermethylation at this locus was significantly higher in HCCs (90%) than noncancerous liver tissues ( P &lt; .001). Loss ofheterozygosity at the D17S5 locus, which was preceded by DNA hypermethylation at the same locus, was detected in 54% of HCCs. The HIC–1 mRNA expression level of noncancerous liver tissues showing chronic hepatitis or cirrhosis was significantly lower than that of noncancerous liver tissues showing no remarkable histological findings ( P &lt; .01), and that of HCCs was even lower than that of noncancerous liver tissues ( P &lt; .05). Poorly differentiated HCCs showed lower expression levels than well– to moderately differentiated HCCs. Mutation of the p53 gene may be involved in HIC–1 inactivation. Moreover, wild–type p53 did not overcome DNA hypermethylation at the D17S5 locus to activate HIC–1 in HCCs. These data suggest that aberrant DNA methylation at this locus and reduced HIC–1 mRNA expression participate in hepatocarcinogenesis during both early developmental stages and malignant progression of HCCs.