Vitamin and Mineral Supplements in the Primary Prevention of Cardiovascular Disease and Cancer
Authors: Stephen P. Fortmann, Evelyn P. Whitlock, Brittany U. Burda
Journal: Annals of Internal Medicine (2014)

Letters6 May 2014Vitamin and Mineral Supplements in the Primary Prevention of Cardiovascular Disease and CancerStephen P. Fortmann, MD, Evelyn P. Whitlock, MD, MPH, and Brittany U. Burda, MPHStephen P. Fortmann, MDFrom Kaiser Permanente Center for Health Research, Portland, Oregon., Evelyn P. Whitlock, MD, MPHFrom Kaiser Permanente Center for Health Research, Portland, Oregon., and Brittany U. Burda, MPHFrom Kaiser Permanente Center for Health Research, Portland, Oregon.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/L14-5009-5 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail IN RESPONSE:We agree with Drs. Padayatty and Levine that it is appropriate to limit any implications of our findings to well-nourished people and to the end points included in our review. We did not conclude that supplements have no value but that there is insufficient evidence of value. We also noted that our conclusions do not apply to persons with vitamin or mineral deficiencies; studies in these populations will need to be done carefully, with prior evidence of or consensus on appropriate measures to use and what constitutes a deficiency (not just biochemically but biologically).Drs. Dror and Stern ...References1. Hemilä H, Kaprio J. Modification of the effect of vitamin E supplementation on the mortality of male smokers by age and dietary vitamin C. Am J Epidemiol. 2009;169:946-53. [PMID: 19218294] CrossrefMedlineGoogle Scholar2. Hemilä H, Kaprio J. Vitamin E may affect the life expectancy of men, depending on dietary vitamin C intake and smoking. Age Ageing. 2011;40:215-20. [PMID: 21242192] CrossrefMedlineGoogle Scholar3. Bolland MJ, Avenell A, Baron JA, Grey A, MacLennan GS, Gamble GD, et al. Effect of calcium supplements on risk of myocardial infarction and cardiovascular events: meta-analysis. BMJ. 2010;341:c3691. [PMID: 20671013] CrossrefMedlineGoogle Scholar4. Bristow SM, Bolland MJ, MacLennan GS, Avenell A, Grey A, Gamble GD, et al. Calcium supplements and cancer risk: a meta-analysis of randomised controlled trials. Br J Nutr. 2013;110:1384-93. [PMID: 23601861] CrossrefMedlineGoogle Scholar5. Elamin MB, Abu Elnour NO, Elamin KB, Fatourechi MM, Alkatib AA, Almandoz JP, et al. Vitamin D and cardiovascular outcomes: a systematic review and meta-analysis. J Clin Endocrinol Metab. 2011;96:1931-42. [PMID: 21677037] CrossrefMedlineGoogle Scholar Author, Article, and Disclosure InformationAuthors: Stephen P. Fortmann, MD; Evelyn P. Whitlock, MD, MPH; Brittany U. Burda, MPHAffiliations: From Kaiser Permanente Center for Health Research, Portland, Oregon.Disclosures: Disclosures can be viewed at www.acponline.org/authors/icmje/ConflictOfInterestForms.do?msNum=M13-1702. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoVitamin and Mineral Supplements in the Primary Prevention of Cardiovascular Disease and Cancer: An Updated Systematic Evidence Review for the U.S. Preventive Services Task Force Stephen P. Fortmann , Brittany U. Burda , Caitlyn A. Senger , Jennifer S. Lin , and Evelyn P. Whitlock Vitamin and Mineral Supplements in the Primary Prevention of Cardiovascular Disease and Cancer Sebastian J. Padayatty and Mark Levine Vitamin and Mineral Supplements in the Primary Prevention of Cardiovascular Disease and Cancer Yosef Dror and Felicia Stern Vitamin and Mineral Supplements in the Primary Prevention of Cardiovascular Disease and Cancer Harri Hemilä Vitamin and Mineral Supplements in the Primary Prevention of Cardiovascular Disease and Cancer Mark J. Bolland , Andrew Grey , and Ian R. Reid Vitamin and Mineral Supplements in the Primary Prevention of Cardiovascular Disease and Cancer Harri Hemilä Vitamin and Mineral Supplements in the Primary Prevention of Cardiovascular Disease and Cancer Yosef Dror and Felicia Stern Vitamin and Mineral Supplements in the Primary Prevention of Cardiovascular Disease and Cancer Mark J. Bolland , Andrew Grey , and Ian R. Reid Vitamin and Mineral Supplements in the Primary Prevention of Cardiovascular Disease and Cancer Sebastian J. Padayatty and Mark Levine Metrics Cited byAntioxidants in smokersStable Ischemic Heart DiseaseDaniel Katz, MD and Michael C. Gavin, MD, MPHAssociation between Dietary Zinc Intake and Hyperuricemia among Adults in the United StatesNonalcoholic fatty liver disease, association with cardiovascular disease and treatment (II). The treatment of nonalcoholic fatty liver diseaseEnfermedad del hígado graso no alcohólico, asociación con la enfermedad cardiovascular y tratamiento (II). Tratamiento de la enfermedad del hígado graso no alcohólicoA Healthy Dietary Pattern Reduces Lung Cancer Risk: A Systematic Review and Meta-Analysis 6 May 2014Volume 160, Issue 9Page: 656KeywordsBiologicsCancer preventionCardiovascular diseasesDietDisclosureMortalityNutrientsPopulation statisticsVitamin E ePublished: 6 May 2014 Issue Published: 6 May 2014 Copyright & PermissionsCopyright © 2014 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...