tbuckley/cabot-search huggingface dataset:
SELDI-TOF MS proteinchip technology for screening of serum markers of HBV-induced hepatocellular carcinoma.
Authors: X Geng, F Wang, Y G Li, G P Zhu, W M Zhang
Journal: Journal of experimental & clinical cancer research (2007)

The incidence of hepatocellular carcinoma (HCC) is highest among primary liver cancer. HBV and HBV-induced liver cirrhosis may lead to HCC (1). At present, it is difficult to diagnose HCC at early stage or to differentiate HCC. Therefore, it is much needed to explore and develop a simple, rapid diagnostic method, which has higher sensitivity and specificity for HCC at early stage (2, 3). Surface-enhanced laser desorption/ionization time-of-flight mass spectrometry (SELDI-TOF MS) is a novel non-electrophoresis-based proteomic technology. SELDI offers the advantages of rapid and simple examination as well as high specificity and sensitivity (4, 5). To our knowledge,there has been little study reported using SELDI-TOF-MS technology to investigate HCC. In this study, 25 cases of HCC patients not receiving any therapy, 25 cases receiving the interposition chemotherapy and 50 cases of the healthy people were tested by Weak cationic exchange (WCX2) protein chip and SELDI-TOF-MS. The differentially expressed peptides or proteins were analyzed by BioMarker Wizard software. At the different M/Z value range, seven peptides/ proteins were obviously different among these three groups. Four peptides including 6489.48Da, 6662.34Da, 8593.75Da and 8720.23Da were up-regulated in healthy controls, two including 7777.27Da and 9250.00Da were up-regulated in the patients with HCC without receiving any therapy and one protein of 16200.17Da was up-regulated in the patients with HCC receiving the interposition chemotherapy. Using Biomarker Pattern software, one pattern including two peptides (7777.27Da, 9250.00Da) can separate HCC without receiving any therapy from normal controls. This diagnosis pattern gave the much-improved sensitivity of 92% and the specificity of 100%. Through searching protein database, these seven peptides or proteins were identified as possible Galanin related peptide, Pro-neuregulin-4 protein, small inducible cytokine A15 precursor, 9 kDa protein, CSL-zincfinger protein 1, mitochondrial hinge protein, actin related protein, respectively. Using SELDI-TOF MS, the method of sieving the tumor markers from HCC becomes quick and valid. These differentially expressed peptides or proteins could be biomarkers of HCC in the serum and drug targets for treating HCC.
Sequential Events in Induction of Sarcomas by 4-Hydroxyaminoquinoline 1-0xide: Fibroplasia, a Premalignant Phase2
Authors: Alan Shurgin, Frederick F. Becker
Journal: JNCI Journal of the National Cancer Institute (1974)

Journal Article Sequential Events in Induction of Sarcomas by 4-Hydroxyaminoquinoline 1-0xide: Fibroplasia, a Premalignant Phase Get access Alan Shurgin, Alan Shurgin Search for other works by this author on: Oxford Academic PubMed Google Scholar Frederick F. Becker Frederick F. Becker Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 53, Issue 1, July 1974, Pages 159–164, https://doi.org/10.1093/jnci/53.1.159 Published: 01 July 1974 Article history Received: 12 November 1973 Accepted: 25 March 1974 Published: 01 July 1974
Intern and Resident Workflow Patterns on Pediatric Inpatient Units
Authors: Amy J. Starmer, Lauren Destino, Catherine S. Yoon, Christopher P. Landrigan
Journal: JAMA Pediatrics (2015)

As resident-physician work hours have decreased, and patient complexity 1 and hospital documentation 2 have concurrently increased, concerns have mounted about the time residents have available for education and face-to-face patient care.Single-center internal medicine studies have found that 12% of trainee time is spent with patients vs 40% in front of the computer. 3,4To our knowledge, no multicenter studies have evaluated this issue in any specialty, including pediatrics.We sought to quantify the proportion of time spent by residents in direct care, indirect care activities, and education across 9 pediatric institutions.Methods | We conducted time-motion observations on the pediatric wards of 9 hospitals.Institutional review board approval
Bendamustine Plus Rituximab Versus Fludarabine Plus Rituximab In Patients with Relapsed Follicular, Indolent and Mantle Cell Lymphomas – Final Results of the Randomized Phase III Study NHL 2–2003 on Behalf of the StiL (Study Group Indolent Lymphomas, Germany)
Authors: Mathias J Rummel, Ulrich Kaiser, Christina Balser, Martina Beate Stauch, Wolfram Brugger, Manfred Welslau, Norbert Niederle, Christoph Losem, Harald Ballo, Eckhart Weidmann, Ulrich von Gruenhagen, Lothar Mueller, Michael Sandherr, Julia Vereschagina, Axel Hinke, Juergen Barth
Journal: Blood (2010)
Multicenter randomized controlled clinical trial to evaluate cardioprotection of dexrazoxane versus no cardioprotection in women receiving epirubicin chemotherapy for advanced breast cancer.
Authors: M Venturini, A Michelotti, L Del Mastro, L Gallo, F Carnino, O Garrone, C Tibaldi, N Molea, R C Bellina, P Pronzato, P Cyrus, J Vinke, F Testore, M Guelfi, R Lionetto, P Bruzzi, P F Conte, R Rosso
Journal: Journal of Clinical Oncology (1996)

PURPOSE Dexrazoxane was found effective in reducing doxorubicin cardiotoxicity when given at a dose ratio (dexrazoxane: doxorubicin) of 20:1. Preclinical studies indicated that dexrazoxane at a dose ratio of 10 to 15:1 also protected against epirubicin-induced cardiotoxicity. The main objective of this study was to investigate the efficacy of dexrazoxane, given at a dose ratio of 10:1 against epirubicin cardiotoxicity. PATIENTS AND METHODS One hundred sixty-two advanced breast cancer patients were randomized to receive epirubicin-based chemotherapy with or without dexrazoxane. Patients who had previously received adjuvant chemotherapy that contained anthracyclines were treated with cyclophosphamide 600 mg/m2 intravenously (IV), epirubicin 60 mg/m2 IV, and fluorouracil 600 mg/m2 IV, on day 1 every 3 weeks. The other patients were treated with epirubicin 120 mg/m2 IV on day 1 every 3 weeks. Cardiac toxicity was defined as clinical signs of congestive heart failure, a decrease in resting left ventricular ejection fraction (LVEF) to &lt; or = 45%, or a decrease from baseline resting LVEF of &gt; or = 20 EF units. RESULTS One hundred sixty patients were evaluated. Cardiotoxicity was recorded in 18 of 78 patients (23.1%) in the control arm and in six of 82 (7.3%) in the dexrazoxone arm. The cumulative probability of developing cardiotoxicity was significantly lower in dexrazoxane-treated patients than in control patients (P = .006; odds ratio, 0.29; 95% confidence limit [CL], 0.09 to 0.78). Noncardiac toxicity, objective response, progression-free survival, and overall survival were similar in both arms. CONCLUSION Dexrazoxane given at a dexrazoxane:epirubicin dose ratio of 10:1 protects against epirubicin-induced cardiotoxicity and does not affect the clinical activity and the noncardiac toxicity of epirubicin. The clinical use of dexrazoxane should be recommended in patients whose risk of developing cardiotoxicity could hamper the eventual use and possible benefit of epirubicin.
Long term sensitisation of cough and expiration reflex in adult rabbits by 48 hour postnatal normobaric hyperoxia
Authors: Silvia Varechova, Bruno Demoulin, Yanis Inglebert, Than Le Tuan, Anne Laure Leblanc, Cyril Schweitzer, François Marchal
Journal: European Respiratory Journal (2012)

Rationale . Cough is a frequent report in follow up studies of late premature children at school age. On the other ahnd, the experimental evidence exists in adult animals that the short term effect of acute hyperoxia is to down regulate cough. The  hypothesis  that neonatal exposure to hyperoxia may interfere with incidence of cough at school age has not been tested previously.  The  aim of the study  was to determine whether postnatal administration of oxygen in pups alters the cough reflex in adult rabbits.   Methods . Rabbits were exposed within the first 8 days of life to 48h normobaric hyperoxia (FIO2 > 93%; n = 12) or ambient air (control; n = 9). At age 3 - 4 months the animal was anesthetized, tracheotomized and subjected to a series of discrete mechanical stimulations of the trachea lasting 50, 150, 300 and 600ms. Each stimulus was quadrupled so as to total 24 stimulations per animal. Cough and expiration reflex were identified from breathing flow and volume, respectively as a forced expiratory effort preceded (cough) or not (expiration reflex) by an increased inspiration.   Results . The incidence of either cough (66/288: 23%) or expiration reflex (124/288: 43%) in hyperoxic rabbits was significantly larger than its respective control (cough: 25/214: 12%; expiration reflex: 60/214: 28%; p = 0.0005).   Conclusion.  The experimental evidence of long term sensitisation of airway defensive reflexes in rabbits breathing high oxygen soon after birth favours a role for neonatal hyperoxia in the pathogenesis of chronic cough at school age in late premature children.
Abstract P004: Three Year Trends of Ideal Cardiovascular Health Metrics Among Employees of a Large Health Care Organization: The Baptist Health South Florida Employee Study
Authors: Oluseye Ogunmoroti, Adnan Younus, Maribeth Rouseff, Ehimen Aneni, Sankalp Das, Don Parris, Leah Holzwarth, Henry Guzman, Thinh Tran, Omar Jamal, Shozab Ali, Muhammad Aziz, Rehan Malik, Rameez Ahmad, Chukwuemeka Osondu, Janisse Post, Arthur Agatston, Theodore Feldman, Michael Ozner, Emir Veledar, Khurram Nasir
Journal: Circulation (2015)

BACKGROUND: More than 1 in 3 U.S. adults has cardiovascular disease (CVD). The U.S. workforce makes up over 50% of the entire population, making the workplace the ideal setting for addressing the burden of CVD. This study used the American Heart Association’s (AHA) cardiovascular (CV) health metrics to assess the risk of CVD over 3 years among employees of Baptist Health South Florida (BHSF), a large nonprofit health care organization. METHODS: Ideal CV health is defined by the AHA as meeting ideal status in 7 health metrics: diet, body mass index (BMI), physical activity, blood pressure, total cholesterol, blood glucose and smoking. The health metrics were calculated using data collected annually from voluntary wellness fairs and health risk assessments. Each metric was categorized as ideal, intermediate or poor according to AHA criteria. RESULTS: Data were collected for a total of 6147 employees in 2011, 11112 in 2012 and 9996 in 2013. For each year, approximately 75% were women and mean age (SD) was 43...
Noninvasive Ventilation as a Systematic Extubation and Weaning Technique in Acute-on-Chronic Respiratory Failure
Authors: CHRISTOPHE GIRAULT, ISABELLE DAUDENTHUN, VIRGINIE CHEVRON, FABIENNE TAMION, JACQUES LEROY, GUY BONMARCHAND
Journal: American Journal of Respiratory and Critical Care Medicine (1999)

Prolonged duration of endotracheal mechanical ventilation (ETMV) is associated with an increased morbidity and mortality in intensive care unit (ICU) patients. The aim of this study was to assess the usefulness of noninvasive ventilation (NIV) as a systematic extubation and weaning technique to reduce the duration of ETMV in acute-on-chronic respiratory failure (ACRF). Among 53 consecutively intubated patients admitted for ACRF, we conducted a prospective, randomized controlled trial of weaning in 33 patients who failed a 2-h T-piece weaning trial (2 h-WT) although they met simple criteria for weaning. Conventional invasive pressure support ventilation (IPSV) was used as the control weaning technique in 16 patients (IPSV group), and NIV was applied immediately after extubation in 17 patients (NIV group). The two weaning groups were similar for type of chronic respiratory failure (CRF), pulmonary function data, age, Simplified Acute Physiology Score (SAPS II), and severity of ACRF on admission. The characteristics of the two groups were also similar at randomization. In the IPSV group, 12 of 16 patients (75%) were successfully weaned and extubated, versus 13 of 17 (76.5%) in the NIV group (p = NS). NIV like IPSV significantly and similarly improved gas exchange in relation to that achieved during 2 h-WT (p < 0.05). The duration of ETMV was significantly shorter in the NIV (4.56 ± 1.85 d) than in the IPSV group (7.69 ± 3.79 d) (p = 0.004). NIV also reduced the mean period of daily ventilatory support, but increased the total duration of ventilatory support related to weaning (3.46 ± 1.42 d, versus 11.54 ± 5.24 d with NIV; p = 0.0001). Most patients in the IPSV group developed complications related to ETMV and / or the weaning process, but the difference was not significant (nine of 16 versus six of 17). The durations of ICU and hospital stays and the 3-mo survival were similar in the two groups. In conclusion, NIV permits earlier removal of the endotracheal tube than with conventional IPSV, and reduces the duration of daily ventilatory support without increasing the risk of weaning failures. NIV should be considered as a new and useful systematic approach to weaning in patients with ACRF who are difficult to wean.
Hybrid Revascularization Strategy
Authors: Giedrius Davidavicius, Frank Van Praet, Samer Mansour, Filip Casselman, Jozef Bartunek, Ivan Degrieck, Francis Wellens, Raf De Geest, Hugo Vanermen, William Wijns, Bernard De Bruyne
Journal: Circulation (2005)

Robotically enhanced minimally invasive direct coronary artery bypass (RE-MIDCAB) graft of the left internal mammary artery to the left anterior descending coronary artery (LAD) and/or the first diagonal branch might be the least traumatic surgical revascularization approach available so far. When combined with fractional flow reserve (FFR)-guided percutaneous coronary intervention (PCI) in the non-LAD vessels, this "hybrid" strategy takes advantage of the survival benefit conferred by the internal mammary artery graft to the LAD while providing the patients with a truly minimally invasive, functionally complete revascularization.Twenty patients with multivessel disease were selected to undergo combined PCI and RE-MIDCAB because they had a lesion amenable to PCI in the right and/or the left circumflex coronary artery and a lesion in the LAD and/or the first diagonal branch that was considered less than ideal for PCI. PCI was actually performed only when FFR was <0.80 ("provisional PCI"). In 7 stenoses, FFR was >0.80 and the planned PCI was not performed. Surgery was performed before provisional PCI in 6 cases. An angiogram was obtained in all patients before discharge, and a complete clinical follow-up including a stress test was obtained in all patients after a mean of 12 months. There were no significant intraoperative complications, conversions to cardiopulmonary bypass, or reinterventions for bleeding. At early control angiogram, 2 moderate stenoses just proximal to anastomosis were observed, both with normal run-off. After 12 months there were no objective signs of ischemia at stress testing. After an average follow-up of 19+/-10 months there were no deaths, myocardial infarctions, or repeat revascularizations.A hybrid strategy combining FFR-guided PCI and RE-MIDCAB seems safe and provides selected patients with a functionally complete revascularization with minimal surgical trauma and excellent clinical outcomes.
Second Line Treatment in Small-Cell Lung Cancer (Sclc) Patients: Single Center 10-Years Experience and Feasibility of Epirubicin Plus Paclitaxel Regimen
Authors: G. Pasello, P. Carli, F. Canova, V. Polo, L. Bonanno, G. Zago, P.F. Conte, A. Favaretto
Journal: Annals of Oncology (2014)
Drug Treatments for Mastalgia: 17 Years Experience in the Cardiff Mastalgia Clinic
Authors: C A Gateley, M Miers, R E Mansel, L E Hughes
Journal: Journal of the Royal Society of Medicine (1992)

Mastalgia commonly presents to medical practitioners. The majority of patients can be managed by exclusion of cancer and reassurance. In some the severity of pain affects the quality of life and drug treatment should be considered. Since its inception 324 patients with cyclical mastalgia and 90 with non-cyclical mastalgia have received a therapeutic trial of drug treatment in the Cardiff Mastalgia Clinic. Overall 92% of those with cyclical mastalgia and 64% with non-cyclical mastalgia obtained a clinically useful response to therapy. Danazol was the most effective drug, with bromocriptine and evening primrose oil having equivalent efficacy. Many fewer adverse events were complained of by patients treated with evening primrose oil than danazol or bromocriptine.
Prognosis of left‐sided infective endocarditis in patients transferred to a tertiary‐care hospital—prospective analysis of referral bias and influence of inadequate antimicrobial treatment
Authors: N. Fernández‐Hidalgo, B. Almirante, P. Tornos, M.T. González‐Alujas, A.M. Planes, M.N. Larrosa, A. Sambola, A. Igual, A. Pahissa
Journal: Clinical Microbiology and Infection (2010)
Psoriasis patients with antibodies to gliadin can be improved by a gluten-free diet
Authors: G. Michaëlsson, B. Gerdén, E. Hagforsen, B. Nilsson, I. Pihl-Lundin, W. Kraaz, G. Hjelmquist, L. Lööf
Journal: British Journal of Dermatology (2000)

In a previous screening study, 16% of patients with psoriasis had IgA and/or IgG antibodies to gliadin (AGA). The aim of the present study was to evaluate the effect of a gluten-free diet (GFD) in 33 AGA-positive and six AGA-negative psoriasis patients. Of the 33 AGA-positive patients, two had IgA antibodies to endomysium (EmA) and 15 an increased number of lymphocytes in the duodenal epithelium, but in some this increase was slight. Two patients had villous atrophy. A 3-month period on a GFD was followed by 3 months on the patient's ordinary diet. The severity of psoriasis was evaluated with the psoriasis area and severity index (PASI). The examining dermatologists were unaware of the EmA and duodenal biopsy results throughout the study. Thirty of the 33 patients with AGA completed the GFD period, after which they showed a highly significant decrease in mean PASI. This included a significant decrease in the 16 AGA-positive patients with normal routine histology in duodenal biopsy specimens. The AGA-negative patients were not improved. After GFD, the AGA values were lower in 82% of those who improved. There was a highly significant decrease in serum eosinophil cationic protein in patients with elevated AGA. When the ordinary diet was resumed, the psoriasis deteriorated in 18 of the 30 patients with AGA who had completed the GFD period. In conclusion, psoriasis patients with raised AGA might improve on a GFD even if they have no EmA or if the increase in duodenal intraepithelial lymphocytes is slight or seemingly absent.
Scrap NHS 111, and "strangle at birth" any similar proposals, say GPs
Authors: A. Rimmer
Journal: BMJ (2015)

GPs have called for the NHS 111 telephone service to be scrapped. Delegates at the BMA’s conference of local medical committees in London on Thursday 21 May voted in favour of a motion calling for the non-emergency telephone helpline to be scrapped. NHS 111 was launched in 2013 and has been blamed for increasing waiting times in emergency care. …
Vinblastine plus ifosfamide plus cisplatin as initial salvage therapy in recurrent germ cell tumor.
Authors: P J Loehrer, R Gonin, C R Nichols, T Weathers, L H Einhorn
Journal: Journal of Clinical Oncology (1998)

PURPOSE This study was designed to assess the effectiveness of vinblastine, ifosfamide, and cisplatin (VeIP) as second-line therapy in patients with recurrent germ cell tumors with previous treatment with cisplatin plus etoposide, usually in combination with bleomycin. PATIENTS AND METHODS From July 1984 through December 1989, 135 patients with progressive, disseminated germ cell tumors after cisplatin-etoposide-based combination therapy induction chemotherapy were treated with VeIP. Patients who progressed within 3 weeks of previous cisplatin therapy were not eligible. Progression was documented by biopsy or increasing serum markers. No exclusion was made on the basis of metastatic site or performance status. The dosages were vinblastine 0.11 mg/kg/d (days 1 and 2), ifosfamide 1.2 gm/m2/d (days 1 through 5), and cisplatin 20 mg/m2/d (days 1 through 5), with courses repeated every 21 days for four cycles. RESULTS Sixty-seven (49.6%) patients achieved a disease-free status after chemotherapy with or without surgical resection of residual carcinoma or teratoma. Overall, 42 (32%) patients are alive and 32 (23.7%) are continuously free of disease. None of the 32 patients with nonseminomatous extragonadal tumors are disease-free compared with 30 of 100 patients with gonadal primaries. Two of three extragonadal seminomas are continuously disease-free. CONCLUSION VeIP is capable of producing durable complete remissions in patients with disseminated germ cell cancer who relapse after cisplatin-etoposide-based induction therapy. Long-term disease-free survival is not seen in those patients with extragonadal nonseminomatous germ cell tumors.
Secondary brain tumors in children treated for acute lymphoblastic leukemia at St Jude Children's Research Hospital.
Authors: A W Walter, M L Hancock, C H Pui, M M Hudson, J S Ochs, G K Rivera, C B Pratt, J M Boyett, L E Kun
Journal: Journal of Clinical Oncology (1998)

PURPOSE To evaluate the incidence of and potential risk factors for second malignant neoplasms of the brain following treatment for childhood acute lymphoblastic leukemia (ALL). PATIENTS AND METHODS The study population consisted of 1,612 consecutively enrolled protocol patients treated on sequential institutional protocols for newly diagnosed ALL at St Jude Children's Research Hospital (SJCRH) between 1967 and 1988. The median follow-up duration is 15.9 years (range, 5.5 to 29.9 y). RESULTS The cumulative incidence of brain tumors at 20 years is 1.39% (95% confidence interval [CI], 0.63% to 2.15%). Twenty-two brain tumors (10 high-grade gliomas, one low-grade glioma, and 11 meningiomas) were diagnosed among 21 patients after a median latency of 12.6 years (high-grade gliomas, 9.1 years; meningiomas, 19 years). Tumor type was linked to outcome, with patients who developed high-grade tumors doing poorly and those who developed low-grade tumors doing well. Risk factors for developing any secondary brain tumor included the presence of CNS leukemia at diagnosis, treatment on Total X therapy, and the use of cranial irradiation, which was dose-dependent. Age less than 6 years was associated with an increased risk of developing a high-grade glioma. CONCLUSION This single-institution study, with a high rate of long-term data capture, demonstrated that brain tumors are a rare, late complication of therapy for ALL. We report many more low-grade tumors than others probably because of exhaustive long-term follow-up evaluation. The importance of limiting cranial radiation is underscored by the dose-dependent tumorigenic effect of radiation therapy seen in this study.