Nail Pigmentation with Daunorubicin Therapy
Authors: MARIAN deMARINIS
Journal: Annals of Internal Medicine (1978)

Brief Reports1 October 1978Nail Pigmentation with Daunorubicin TherapyMARIAN deMARINIS, M.D., ANDREW HENDRICKS, M.D., GORDON STOLTZNER, M.D.MARIAN deMARINIS, M.D., ANDREW HENDRICKS, M.D., GORDON STOLTZNER, M.D.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-89-4-516 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptPigmentary abnormalities in the nails have been described after cancer chemotherapy. Doxorubicin (Adriamycin®) is one agent implicated in the production of hyperpigmented bands in the nails of patients with cancer on single or combination drug regimens (1-6). This report concerns transverse nail pigmentation after a chemotherapeutic regimen in which daunorubicin (Daunomycin®), a drug with a close structural resemblance to doxorubicin, was administered.A 22-year-old black woman developed erythematous, tender nodules over the extensor surfaces of her arms and thighs in January 1977. Skin biopsy of a nodule showed hypersensitivity angiitis with a leukemic infiltrate. Smears of peripheral blood and bone...References1. NIXON D: Alterations in nail pigment with cancer chemotherapy. Arch Intern Med 136:1117-1118, 1976 CrossrefMedlineGoogle Scholar2. PRATTSHANKS CE: Hyperpigmentation of nails from doxorubicin (letter). JAMA 228:460, 1974 CrossrefMedlineGoogle Scholar3. ROTHBERGPLACESHTEIR HCO: Adriamycin (NSC-123127) toxicity: unusual melanotic reaction. Cancer Chemother Rep 58:749-751, 1974 MedlineGoogle Scholar4. LAW I: Doxorubicin and unusual skin manifestations (letter). Arch Dermatol 113:379-380, 1977 CrossrefMedlineGoogle Scholar5. MORRISAISNERWIERNIK DJP: Horizontal pigmented banding of the nails in association with adriamycin chemotherapy. Cancer Treat Rep 61:499-500, 1977 MedlineGoogle Scholar6. PRIESTMANJAMES TK: Adriamycin and longitudinal pigmented banding of fingernails (letter). Lancet 1:1337, 1975 CrossrefMedlineGoogle Scholar7. DI MARCOGAETANISCARPINATO AMB: Adriamycin (NSC-123127): a new antibiotic with antitumor activity. Cancer Chemother Rep. 53:33-37, 1969 MedlineGoogle Scholar8. LERNERMCGUIRE AJ: Melanocyte-stimulating hormone and adrenocorticotropic hormone: their relation to pigmentation. N Engl J Med 270:539-546, 1964 CrossrefMedlineGoogle Scholar9. BONDYHARWICK PH: Longitudinal banded pigmentation of nails following adrenalectomy for Cushing's syndrome. N Engl J Med 281:1056-1057, 1969 CrossrefMedlineGoogle Scholar10. VARGAASATOLANDELERNER JNSA: Melanotropin-daunomycin conjugate shows receptor-mediated cytotoxicity in cultured murine melanoma cells. Nature 267:56-58, 1977 CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: The Johns Hopkins Hospital Baltimore, Maryland PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByDrug-induced Nail ChangesNail Toxicity Induced by Cancer ChemotherapySystemic DrugsGeneralized hyperpigmentation with daunorubicin chemotherapyTransverse Leukonychia (Mees' Lines) Due to aunorubidn ChemotherapyMUCOCUTANEOUS MANIFESTATIONS OF LYMPHOMAS AND LEUKEMIAS IN BLACK KENYAN CHILDRENCUTANEOUS HYPERPIGMENTATION CAUSED BY SYSTEMIC DRUGSCutaneous pigmentation after daunorubicin chemotherapyMucocutaneous side effects of chemotherapyHyperpigmentation of the Nail from Lead DepositionCutaneous Side Effects of Cancer ChemotherapyCutaneous complications of chemotherapeutic agentsNail DyschromiaThe flag sign of chemotherapyDrug- and heavy metal-induced hyperpigmentationCytostatic and immunosuppressive drugs 1 October 1978Volume 89, Issue 4Page: 516-517KeywordsBiopsyBloodBoneCancer chemotherapyDrugsHypersensitivityVasculitis Issue Published: 1 October 1978 PDF DownloadLoading ...