tbuckley/cabot-search huggingface dataset:
Abstract P299: Narrowing Of Retinal Arterioles Is Associated With Increased Risk Of Incident Microalbuminuria
Authors: Atsushi Hirayama, Ryo Kawasaki, Tsuneo Konta, Tetsu Watanabe, Yoko Shibata, Akira Fukao, Isao Kubota
Journal: Circulation (2014)

Microalbuminuria is known as an independent risk factor of cardiovascular diseases. Retinal vessel caliber size is also linked to increased risk of stroke and coronary heart disease. Although there are shared anatomical and physiological characteristics between renal and retinal microvasculature, longitudinal study between renal and retinal microvasculature to illustrate temporal association is scarce. To determine whether retinal vessel caliber size at baseline associated with incidence of microalbuminuria in a general Japanese population study of the Takahata study. We conducted a community-based longitudinal cohort study, the Takahata study (Yamagata, Japan). In 2004-6, 711 individuals without microalbuminuria were identified at baseline examination. Microalbuminuria was defined as the urinary albumin-to-creatinine ratio (UACR) ≥ 30 mg/g. Retinal vessel caliber was determined using semi-automatic software (IVAN, Wisconsin University) as the central retinal artery and vein equivalent (CRAE and CRVE). We analyzed the association between baseline retinal vessel calibers and cumulative incidence of microalubuminuria using multivariate logistic regression model adjusting for age, sex, body mass index, systolic and diastolic blood pressure, Hemoglobin (Hb) A1c, UACR at baseline, and smoking. During follow-up period (mean, 6.7 years±0.6), 45 subjects (6.3%) developed microalbuminuria. In univariate logistic regression analysis, Age (per 1 years increase, Odds ratio [OR]: 1.05, 95% confidence interval [CI]: 1.01-1.09), HbA1c (per 1% increase, OR: 2.08, 95%CI: 1.28-3.36), UACR at baseline (per 1 mg/g increase, OR: 1.11, 95%CI: 1.06-1.16) were associated with increased risk of developing microalbuminuria. In multivariate logistic regression analysis, HbA1c (OR: 1.86, 95%CI: 1.07-3.24), UACR at baseline (OR: 1.09, 95%CI: 1.04-1.15), and CRAE (per 1SD decrease, OR: 1.45, 95%CI: 1.00-2.12) were significantly associated with increased risk of incident microalbuminuria. In conclusion, narrowing of retinal artery seems to be precedent to the incidence of microalbuminuria in this adult population-based cohort.
Fluorodeoxyglucose positron emission tomography fails to detect distant metastases at initial staging of melanoma patients with metastatic involvement of sentinel lymph node
Authors: T. Wagner, N. Meyer, S. Zerdoud, A. Julian, C. Chevreau, P. Payoux, F. Courbon
Journal: British Journal of Dermatology (2011)

Journal Article Fluorodeoxyglucose positron emission tomography fails to detect distant metastases at initial staging of melanoma patients with metastatic involvement of sentinel lymph node Get access T. Wagner, T. Wagner Nuclear Medicine Department, Toulouse Purpan University Hospital, Place du Dr Baylac, TSA 40031, Toulouse cedex 31059, France Thomas Wagner. E‐mail: thomwagner@hotmail.com Search for other works by this author on: Oxford Academic Google Scholar N. Meyer, N. Meyer Paul‐Sabatier University and Dermatology Department, Toulouse University Hospital, Toulouse, France Search for other works by this author on: Oxford Academic Google Scholar S. Zerdoud, S. Zerdoud Departments of Nuclear Medicine Search for other works by this author on: Oxford Academic Google Scholar A. Julian, A. Julian Nuclear Medicine Department, Toulouse Purpan University Hospital, Place du Dr Baylac, TSA 40031, Toulouse cedex 31059, France Search for other works by this author on: Oxford Academic Google Scholar C. Chevreau, C. Chevreau Medical Oncology, Claudius Regaud Institute, Toulouse, France Search for other works by this author on: Oxford Academic Google Scholar P. Payoux, P. Payoux Nuclear Medicine Department, Toulouse Purpan University Hospital, Place du Dr Baylac, TSA 40031, Toulouse cedex 31059, France Search for other works by this author on: Oxford Academic Google Scholar F. Courbon F. Courbon Departments of Nuclear Medicine Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 164, Issue 6, 1 June 2011, Pages 1235–1240, https://doi.org/10.1111/j.1365-2133.2011.10247.x Published: 01 June 2011
Surrogate Decision Making for Patients Without Nuclear Family
Authors: David Alfandre, Virginia Ashby Sharpe, Kenneth Berkowitz
Journal: JAMA (2015)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome (IPEX) is caused by mutations of FOXP3
Authors: Craig L. Bennett, Jacinda Christie, Fred Ramsdell, Mary E. Brunkow, Polly J. Ferguson, Luke Whitesell, Thaddeus E. Kelly, Frank T. Saulsbury, Phillip F. Chance, Hans D. Ochs
Journal: Nature Genetics (2001)
The clinical course of shoulder pain: prospective cohort study in primary care
Authors: P. Croft, D. Pope, A. Silman
Journal: BMJ (1996)

Study GroupCurrent knowledge of the clinical course and efficacy of treatment for shoulder pain comes mainly from studies of hospital patients.However, only a few patients experiencing such pain require referral to a specialist.Although shoulder pain is common in the general population, the outcome of patients presenting in general practice is unknown.'We conducted a prospec- tive cohort study to determine the outcome of shoulder pain in primary care. Methods and resultsTwelve general practitioners recruited 166 patients who consulted with a new episode of shoulder pain dur- ing one year.They recorded demographic information, diagnosis, management, and an assessment of passive elevation of the shoulder; patients assessed the disability associated with their symptoms with a validated 22 item disability questionnaire.! To assess outcome, identical disability questionnaires were sent to patients six and 18 months after consultation, together with a question measuring self assessed change in symptoms in the intervening period.A total of 125 (75%) patients provided follow up information at six months and 95 (57%) at 18 months.
Label Confusion Leads to Errors
Authors: Rebecca Voelker
Journal: JAMA (2015)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Waist Circumference Thresholds Provide an Accurate and Widely Applicable Method for the Discrimination of Diabetes
Authors: Rachel Huxley, Federica Barzi, Crystal M Y Lee, Scott Lear, Jonathan Shaw, Tai Hing Lam, Ian Caterson, Fereidoun Azizi, Jeetesh Patel, Paibul Suriyawongpaisal, Sang Woo Oh, Jae-Heon Kang, Tim Gill, Paul Zimmet, Philip T James, Mark Woodward
Journal: Diabetes Care (2007)

Excess weight, particularly central obesity, is recognized to be a major determinant of diabetes risk in all populations, with the magnitude of the association reported as being stronger in Asians than whites (1-3). Consequently, indicators of overweight have been incorporated into several guidelines for the early identification of individuals with type 2 diabetes (4). However, the anthropometric cut points for different ethnic groups have been determined in various ways, leading to uncertainty about their applicability to diabetes screening. Here, we clarify current uncertainty regarding ethnic differences in the relationship between overweight and diabetes and whether there is a single measure of overweight that can be determined routinely and applied universally in clinical practice to facilitate earlier detection of diabetes in the general population.
Treatment of Neonatal Sepsis with Intravenous Immune Globulin
Authors: Peter Brocklehurst, Barbara Farrell, Andrew King, Edmund Juszczak, Brian Darlow, Khalid Haque, Alison Salt, Ben Stenson, William Tarnow-Mordi
Journal: New England Journal of Medicine (2011)

Neonatal sepsis is a major cause of death and complications despite antibiotic treatment. Effective adjunctive treatments are needed. Newborn infants are relatively deficient in endogenous immunoglobulin. Meta-analyses of trials of intravenous immune globulin for suspected or proven neonatal sepsis suggest a reduced rate of death from any cause, but the trials have been small and have varied in quality.
Re: Marlon Perera, Matthew J. Roberts, Suhail A.R. Doi, Damien Bolton. Prostatic Urethral Lift Improves Urinary Symptoms and Flow While Preserving Sexual Function for Men with Benign Prostatic Hyperplasia: A Systematic Review and Meta-analysis. Eur Urol 2015;67:704–13
Authors: Matthew J. Roberts, Marlon Perera, Suhail A.R. Doi, Damien Bolton
Journal: European Urology (2015)
Abstract 18776: Could Early Direct Detection of Left Ventricular Assist Device Thrombus Reduce Thrombotic Complications
Authors: Grace Cui, Walter Akers, Michael J Scott, John S Allen, Anne H Schmieder, Scott C Silvestry, Akinobu Itoh, Krishna Paranandi, Yuan-Chuan Tia, Samuel Achilefu, Gregory A Ewald, Gregory M Lanza
Journal: Circulation (2014)

Background:  Treatment of advanced heart failure with implantable LVADs continues to increase. However, LVADs can be associated with serious complications: bleeding, infection, and thrombosis.   Objective:  To develop a sensitive image-guided approach to localize and quantify early thrombus accumulation in titanium LVADs permitting earlier clinical intervention to minimize thrombotic events.   Materials:  A monomeric bifunctional ligand with a fibrin-specific peptide, a short spacer, and 99mTc chelating amino acid sequence (F1A) was developed and compared with a tetrameric (PEG2000) analogue (F4A).   Results:  99mTc attenuation by the LVAD titanium (1mm) was 23%. 99mTc-F1A affinity to fibrin was Kd~10 nM. The 99mTc-F4A probe could not be competitively displaced by F1A up to 120,000:1. In vitro 99mTc-F1A binding to fibrin clot was interfered heavily by plasma (p   0.05). The pharmacokinetic half-life of 99mTc-F4A was faster (124±41min, p    Conclusion:  99mTc-F4A is a high-avidity prototype probe to localize thrombus in LVADs. This may allow earlier clinical intervention to minimize thrombotic complications and the need for pump exchange.
659. Development of Designed Zinc Finger Protein Transcriptional Regulators for Use in Multi-Factor Therapeutic Angiogenesis
Authors: Edward J. Rebar, Brian Johnstone, Pei-Qi Liu, Andrew C. Jamieson, Yuxin Liang, Lei Zhang, Matthew C. Mendel, Lei Xu, Kaye Spratt, Casey C. Case
Journal: Molecular Therapy (2004)

Gene therapy-mediated revascularization strategies offer considerable promise in the treatment of cardiovascular disease. To date, over two dozen studies have reported that gene-based delivery of angiogenic factors can enhance blood flow and/or tissue function in preclinical models of limb and heart ischemia. However, although several programs have advanced into clinical trials, it has been noted that natural angiogenesis proceeds via the coordinate action of multiple factors; therefore strategies utilizing two or more angiogenic factor genes may realize enhanced therapeutic benefit1. In consideration of this possibility we are developing a panel of designed zinc finger protein (ZFP) transcriptional activators for regulation of multiple different angiogenic factor genes. In previous studies we had described the development of pro-angiogenic ZFPs that function via activation of VEGF-A2,3,4. Here we have extended this approach to develop regulators of three additional factors: Ang-1, FGF-5 and VEGF-C. These studies involved: (i) DNase I mapping of accessible locus regions; (ii) design and assembly of ZFPs targeting sites within accessible and/or functional promoter regions; and (iii) ZFP screening for activation of gene expression. By this approach, we have identified ZFPs that activate Ang-1, FGF-5 and VEGF-C by up to 14-fold in cells from both human and mouse. Furthermore, by targeting a sequence common to the promoters of VEGF-A and VEGF-C we have produced a ZFP that coordinately activates both of these genes. The use of designed ZFPs to regulate a patient's own endogenous genetic loci offers a number of advantages over cDNA-based gene therapy approaches, including the capacity to upregulate all splice variants of a therapeutic gene2,3,4, the option for ligand-regulatable protein expression using a single introduced transgene5, and transgene size economy (a critical feature for multi-factor therapies with vectors of limited insert capacity). We anticipate that these ZFPs will provide powerful reagents for the development of multi-factor strategies for therapeutic angiogenesis.
595. Combination Tissue Specific SCC Antigen Promoter with CD/5-FC Gene Therapy Enhances Killing of Human Uterine Cervical Cancer Cells by Radiation
Authors: Keng-Fu Hsu, Cheng-Yang Chou, Helen H. W. Chen, Che-Hsin Lee, Ai-Li Shiau, Chao-Liang Wu
Journal: Molecular Therapy (2004)

Background: Cervical caner is the leading cause of female cancer death worldwide. The squamous cell carcinoma (SCC) antigen was isolated first from uterine cervical SCC tissue in 1977. SCC antigen is a serologic tumor marker for patients with squamous cell carcinoma of the cervix. Serum concentrations of this marker correlate well with stage of disease, the presence or absence of risk factors, the effect of treatment, and the course of the disease. Moreover, the measurement of posttreatment SCC antigen levels is useful for monitoring the response to therapy and for predicting tumor recurrence and metastasis. In advance or recurrence cervical cancer, radiation with chemotherapy including 5-FU is used clinically. However, the morbidity is relative high. Gene therapy combined with radiation represents a new approach to cervical cancer treatment. In the present study, we investigated whether adenovirally directed, SCC antigen promoter with cytosine deaminase (CD)/5-fluorocytosine (5-FC) gene therapy could induce cell toxicity and radiosensitization through the intracellular production of 5-fluorouracil (5-FU) in uterine cervical cancer.
Risk factors for schizophrenia. Follow-up data from the Northern Finland 1966 Birth Cohort Study.
Authors: Matti Isohanni, Jouko Miettunen, Pirjo Mäki, Graham K Murray, Khanum Ridler, Erika Lauronen, Kristiina Moilanen, Antti Alaräisänen, Marianne Haapea, Irene Isohanni, Elena Ivleva, Carol Tamminga, John McGrath, Hannu Koponen
Journal: World Psychiatry (2006)

This paper updates single risk factors identified by the Northern Finland 1966 Birth Cohort Study up to the end of year 2001 or age 34. Impaired performance (e.g., delayed motor or intellectual development) or adverse exposures (e.g., pregnancy and birth complications, central nervous system diseases) are associated with an increased risk for schizophrenia. However, upper social class girls and clever schoolboys also have an increased risk to develop schizophrenia, contrasted to their peers. Individuals who subsequently develop schizophrenia follow a developmental trajectory that partly and subtly differs from that of the general population; this trajectory lacks flexibility and responsiveness compared to control subjects, at least in the early stages. We propose a descriptive, lifespan, multilevel systems model on the development and course of schizophrenia.
Expression of mdr-1 in refractory lymphoma: quantitation by polymerase chain reaction and validation of the assay [published erratum appears in Blood 1995 Dec 15;86(12):4710]
Authors: YK Kang, Z Zhan, J Regis, M Alvarez, R Robey, B Meadows, B Dickstein, JS Lee, T Otsuki, M Stetler-Stevenson
Journal: Blood (1995)
Radikal Tedavi İçin Uygun Olmayan Evre IIIA-IIIB Küçük Hücreli Dışı Akciğer Kanseri Olan Hastalarda Eşzamanlı Kemoterapi ve Kısa Süreli Radyoterapi
Authors: Sergiusz Nawrocki, Maciej Krzakowski, ‡ Ewa Wasilewska-Tesluk, Dariusz Kowalski, Monika Rucinska, Rafal Dziadziuszko, Aleksander Sowa
Journal: Journal of Thoracic Oncology (2010)
Abstract P4-11-27: Prospective comparison of conventional clinicopathological factors, uPA/PAI-1 and EndoPredict®-clin score (EPclin) for adjuvant clinical decision making in ER-positive, HER2-negative breast cancer: Progesterone receptor expression is strongly associat
Authors: Johannes Ettl, Kirsten Große Lackmann, Alexander Hapfelmeier, Evelyn Klein, Stefan Paepke, Christoph Petry, Katja Specht, Laura Wolff, Heinz Höfler, Marion Kiechle
Journal: Cancer Research (2015)

Abstract Background: Recently, EPclin, a second generation multigene test has been introduced into clinical practice. Aim of this prospective study is to compare conventional clinicopathological factors, uPA/PAI-1 and EPclin and to determine, how these parameters influence adjuvant treatment decisions. Methods: 217 consecutive cases of ER-pos, HER2neg, breast cancer cases were enrolled in this study. Conventional clinicopathological factors, uPA/PAI-1 and EPclin were obtained by central pathology assessment of the patients' surgical specimen. Decision for type of adjuvant treatment was made twice – once with and once without EPclin result- after case discussion in an interdisciplinary tumor conference. Results: 217 Patients (pt) have been evaluated. Tumor grading within the presented cohort was as follows: G1: 44 pt (20%), G2: 146 pt (68%), G3: 27 pt (12%). 59 pt (27%) had positive axillary lymph node involvement. 57 pt (26%) were pT1a/b. EPclin could be assessed in all patients. 85 pt (39%) were classified as "high risk" whereas 132 pt (61%) were classified as "low risk". uPA/PAI was obtained from 123 pt (57%). 64 pt (52%) out of these had high uPA/PAI-1 levels whereas 59 pt (48%) showed low uPA/PAI-1 levels. Level of progesterone receptor (PR) expression was obtained from 216 pt. 39 pt (18%) had low or absent PR expression (PR ≤ 20%). 26 pt (67%) of this low PR expression group were classified as EPclin high risk. Furthermore 118 pt (67%) of the high PR expression group (177 pt) were classified as "low risk" via EPclin (p&amp;lt;0,0001). In 89 cases (41%) treatment decision was influenced by EPclin: In 73pt (34%) adjuvant chemotherapy (ctx) was omitted whereas in 16 pt (7%) ctx was added following the EPclin result. Conclusions: This prospective study shows for the first time, that PR expression is strongly associated with risk score evaluated by EPclin testing. In comparison with uPA/PAI-1 and conventional clinicopathological factors EPclin is the more powerful tool to help reduce unnecessary adjuvant chemotherapy. Citation Format: Johannes Ettl, Kirsten Große Lackmann, Alexander Hapfelmeier, Evelyn Klein, Stefan Paepke, Christoph Petry, Katja Specht, Laura Wolff, Heinz Höfler, Marion Kiechle. Prospective comparison of conventional clinicopathological factors, uPA/PAI-1 and EndoPredict®-clin score (EPclin) for adjuvant clinical decision making in ER-positive, HER2-negative breast cancer: Progesterone receptor expression is strongly associat [abstract]. In: Proceedings of the Thirty-Seventh Annual CTRC-AACR San Antonio Breast Cancer Symposium: 2014 Dec 9-13; San Antonio, TX. Philadelphia (PA): AACR; Cancer Res 2015;75(9 Suppl):Abstract nr P4-11-27.
The Clinical Practice of Adolescent Medicine.
Authors: Jerome T. Y. Shen
Journal: Annals of Internal Medicine (1980)

The unique contribution of this book, however, is not its text as much as its superb illustrations from which an enormous amount can be easily learned.The gruesome pictures of some of the late complications, and the growing acceptance of the relationship between these complications and diabetic control, may serve to stimulate greater efforts at control.The colour photographs, covering all aspects of diabetes, are supplemented by diagrams, photomicrographs and reproductions of X-ray pictures, which add to the completeness of the book, and draw attention to some of the recent techniques available as guides to management.Information gained from this colour atlas is likely to be more easily recalled than from a written text, especially when rare conditions are encountered, and thus it will be of enormous value to clinicians.