Tako-Tsubo (Stress-Induced) Cardiomyopathy and Cancer
Authors: Christof Burgdorf
Journal: Annals of Internal Medicine (2010)

Letters15 June 2010Tako-Tsubo (Stress-Induced) Cardiomyopathy and CancerChristof Burgdorf, MD, Holger M. Nef, MD, Dariusch Haghi, MD, Volkhard Kurowski, MD, and Peter W. Radke, MDChristof Burgdorf, MDFrom University Hospital Schleswig-Holstein, 23538 Lübeck, Germany; Kerckhoff Heart and Thorax Center, 61231 Bad Nauheim, Germany; and University Hospital Mannheim, 68167 Mannheim, Germany., Holger M. Nef, MDFrom University Hospital Schleswig-Holstein, 23538 Lübeck, Germany; Kerckhoff Heart and Thorax Center, 61231 Bad Nauheim, Germany; and University Hospital Mannheim, 68167 Mannheim, Germany., Dariusch Haghi, MDFrom University Hospital Schleswig-Holstein, 23538 Lübeck, Germany; Kerckhoff Heart and Thorax Center, 61231 Bad Nauheim, Germany; and University Hospital Mannheim, 68167 Mannheim, Germany., Volkhard Kurowski, MDFrom University Hospital Schleswig-Holstein, 23538 Lübeck, Germany; Kerckhoff Heart and Thorax Center, 61231 Bad Nauheim, Germany; and University Hospital Mannheim, 68167 Mannheim, Germany., and Peter W. Radke, MDFrom University Hospital Schleswig-Holstein, 23538 Lübeck, Germany; Kerckhoff Heart and Thorax Center, 61231 Bad Nauheim, Germany; and University Hospital Mannheim, 68167 Mannheim, Germany.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-152-12-201006150-00026 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail Background: Tako-tsubo cardiomyopathy (TTC) is characterized by transient left ventricular systolic dysfunction in the absence of atherosclerotic coronary artery disease (1, 2). Although TTC is most prevalent in postmenopausal women presenting with acute emotional or physical stress, the underlying pathophysiologic mechanism is not fully understood. Cancer is accompanied by increased psychological stress and elevated sympathetic nervous tone. Thus, it might trigger TTC in susceptible persons. Indeed, we recently found significantly more cases of cancer in 50 patients with TTC than in age- and sex-matched control participants presenting with acute anterior myocardial infarction (3).Objective: To determine the frequency of cancer ...References1. Bybee KA, Kara T, Prasad A, Lerman A, Barsness GW, Wright RS, et al. Systematic review: transient left ventricular apical ballooning: a syndrome that mimics ST-segment elevation myocardial infarction. Ann Intern Med. 2004;141:858-65. [PMID: 15583228] LinkGoogle Scholar2. Prasad A. Apical ballooning syndrome: an important differential diagnosis of acute myocardial infarction. Circulation. 2007;115:56-9. [PMID: 17283269] CrossrefMedlineGoogle Scholar3. Burgdorf C, Kurowski V, Bonnemeier H, Schunkert H, Radke PW. Long-term prognosis of the transient left ventricular dysfunction syndrome (Tako-Tsubo cardiomyopathy): focus on malignancies. Eur J Heart Fail. 2008;10:1015-9. [PMID: 18692439] CrossrefMedlineGoogle Scholar4. Surveillance Epidemiology and End Results. SEER Cancer Statistics Review, 1975–2006. Bethesda, MD: National Cancer Institute. Accessed at seer.cancer.gov/csr/1975_2006/ on 4 May 2010. Google Scholar5. Lutz JM, Francisci S, Mugno E, Usel M, Pompe-Kirn V, Coebergh JW, et al; EUROPREVAL Working Group. Cancer prevalence in Central Europe: the EUROPREVAL Study. Ann Oncol. 2003;14:313-22. [PMID: 12562661] CrossrefMedlineGoogle Scholar Author, Article, and Disclosure InformationAffiliations: From University Hospital Schleswig-Holstein, 23538 Lübeck, Germany; Kerckhoff Heart and Thorax Center, 61231 Bad Nauheim, Germany; and University Hospital Mannheim, 68167 Mannheim, Germany.Disclosures: None disclosed. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoSystematic Review: Transient Left Ventricular Apical Ballooning: A Syndrome That Mimics ST-Segment Elevation Myocardial Infarction Kevin A. Bybee , Tomas Kara , Abhiram Prasad , Amir Lerman , Greg W. Barsness , R. Scott Wright , and Charanjit S. Rihal Metrics Cited byPsychosocial and physical long-term outcome in patients with a history of takotsubo cardiomyopathy or myocardial infarction - a multi-centered case control studyIncidence, clinical features and outcome of Takotsubo syndrome in the intensive care unitInterventional Cardiology in the Cancer PatientClinical Features and Outcomes of Patients With Malignancy and Takotsubo Syndrome: Observations From the International Takotsubo RegistryPlacebo and Nocebo Effects in Patients With Takotsubo Cardiomyopathy and Heart-Healthy ControlsTakotsubo Cardiomyopathy During Anti‐HER2 Therapy for Metastatic Breast CancerInterventional Cardiology in the Cancer PatientTakotsubo syndrome: State-of-the-art review by an expert panel – Part 1Heart of the matter: reverse takotsubo syndrome in an anthracycline-exposed oncology patientTrying to catch the octopus in the trap: Takotsubo syndrome natural historyOutcomes of Takotsubo cardiomyopathy in hospitalized cancer patientsCardiovascular Magnetic Resonance in the Oncology PatientCancer as a Risk Factor for Cardiovascular DiseaseIschemic Heart Disease: Special Considerations in Cardio-OncologyContemporary review on the pathogenesis of takotsubo syndrome: The heart shedding tearsCancer and Takotsubo Syndrome: a Need to Explore a Very Complex AssociationAcute, repetitive and chronic Takotsubo syndrome in patients with chronic kidney disease: Sympathetic reno-cardial syndromeCardiac arrest and ventricular fibrillation in a young man treated with capecitabine: Case report and literature reviewThe intriguing triangle of cancer, chemotherapy and takotsubo syndromeA case of Takotsubo cardiomyopathy after chemotherapyImpact of Malignancies in the Early and Late Time Course of Takotsubo CardiomyopathyIs the specific effect of receiving oxaliplatin, or merely the nonspecific effect of having suffered cancer, the cause of Takotsubo syndrome?Comorbidities Frequency in Takotsubo Syndrome: An International Collaborative Systematic Review Including 1109 PatientsVagotonia, cancer, and fluid depletion in Takotsubo cardiomyopathy: The "not" good, the bad and the uglyIs Takotsubo syndrome in patients receiving chemotherapy drug-specific?Coronary vasospasm is an unlikely cause of Takotsubo syndrome, although we should keep an open mindTakotsubo cardiomyopathy and anaesthesia: Case report and review of the literatureAcute cardiac sympathetic disruption in the pathogenesis of the takotsubo syndrome: A systematic review of the literature to datePredictors of mortality in patients with stress-induced cardiomyopathy developed during critical careChemotherapy-Induced Takotsubo CardiomyopathyCapecitabine caused cardiogenic shock through induction of global takotsubo syndromeChronobiological variation in the occurrence of Tako-tsubo cardiomyopathy: Experiences of two tertiary cardiovascular centersThe Impact of Stressor Patterns on Clinical Features in Patients With Tako-tsubo Cardiomyopathy: Experiences of Two Tertiary Cardiovascular CentersThe Clinical Characteristics, Laboratory Parameters, Electrocardiographic, and Echocardiographic Findings of Reverse or Inverted Takotsubo Cardiomyopathy: Comparison With Mid or Apical VariantTako-Tsubo syndrome: dying of a broken heart? 15 June 2010Volume 152, Issue 12Page: 830-831KeywordsCancer screeningCardiomyopathiesCoronary arteriesHospitalizationsMyocardial infarctionPopulation statisticsPsychological stressRenal cancerStable coronary artery diseaseStomach ePublished: 15 June 2010 Issue Published: 15 June 2010 Copyright & PermissionsCopyright © 2010 by American College of Physicians. 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