Primary Myoglobinuria
Authors: RICHARD JOSEPH DUMA
Journal: Annals of Internal Medicine (1962)

Case Reports1 January 1962Primary MyoglobinuriaA Case Report Emphasizing Recent Diagnostic TechniquesRICHARD JOSEPH DUMA, M.D., JACK W. TRIGG, M.D., WILLIAM J. HAMMACK, M.D.RICHARD JOSEPH DUMA, M.D.Search for more papers by this author, JACK W. TRIGG, M.D.Search for more papers by this author, WILLIAM J. HAMMACK, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-56-1-97 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptPrimary myoglobinuria, also known as idiopathic or paralytic myoglobinuria and recurrent rhabdomyolysis, is a rare disease, 56 cases having been reported to date in the medical literature (1, 2). It is to be differentiated fromsecondarymyoglobinuria occurring following crush injuries (3), high voltage accidents (4), convulsions (5, 6), arterial occlusion (7), and epidemic Haff disease (8). It must also be differentiated from other disorders characterized by the passage of dark urine, such as the porphyrias, march hemoglobinuria, paroxysmal cold hemoglobinuria, paroxysmal nocturnal hemoglobinuria, and the various nephritides. A clinical picture similar to muscular dystrophy has been noted to occur...References1. FARMERHAMMACKFROMMEYER TAWJWB: New Engl. J. Med. 264: 60, 1961. CrossrefMedlineGoogle Scholar2. WHEBYMILLER MSHS: Idiopathic paroxysmal myoglobinuria: report of two cases occurring in sisters. Review of the literature. Amer. J. Med. 29: 599, 1960. CrossrefMedlineGoogle Scholar3. BYWATERSDELORYRIMINGTONSMILES EGGECJ: Myohaemoglobin in the urine of air raid casualties with crushing injury. Biochem. J. 35: 1164, 1941. CrossrefMedlineGoogle Scholar4. FISCHERROSSIER HPH: Starkstromunfälle mit Shweren Muskelschädigungen und Myoglobinurie. Helvet. Med. Acta 14: 212, 1947. MedlineGoogle Scholar5. 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MILLIKAN GA: Muscle hemoglobin. Physiol. Rev. 19: 503, 1939. CrossrefGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Birmingham, AlabamaFrom the Department of Medicine, Medical College of Alabama, and the Veterans Administration Hospital, Birmingham, Alabama.Supported in part by Grants CY3013C2 and C4693 from the National Institutes of Health, Bethesda, Maryland.Requests for reprints should be addressed to Jack W. Trigg, M.D., Department of Medicine, The University of Alabama Medical Center, Medical College of Alabama, Birmingham 3, Alabama. 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HAMPERS, M.D., DAVID PRAGER, M.D. 1 January 1962Volume 56, Issue 1Page: 97-104KeywordsHemoglobinHospital medicineMuscular dystrophiesNephritisPlasma proteinsPorphyriaRhabdomyolysisUltracentrifugationUltrafiltrationUrine Issue Published: 1 January 1962 PDF DownloadLoading ...