tbuckley/cabot-search huggingface dataset:
Abstract 20395: Racial/Ethnic and Gender Disparities in Use of Drug-Eluting vs. Bare Metal Stents in ST-Elevation Myocardial Infarction Patients, 2006-2012
Authors: Jason L Salemi, Amit P Pathak, Elizabeth B Pathak
Journal: Circulation (2014)

Background: Recent evidence continues to show the benefit of drug-eluting stents (DES) over bare metal stents (BMS) in patient outcomes following ST-elevation myocardial infarction (STEMI), although the use of DES may be contraindicated in patients with specific comorbidities. In this study, we investigated racial/ethnic and gender disparities in the use of DES, after controlling for the effects of age, insurance status, secular trends, and comorbidities. Methods: The study population included all STEMI patients (n=60,218) who received PCI and at least one stent in any Florida acute-care hospital during 2006-2012. Hospital discharge data were analyzed. Procedure codes identified DES (ICD-9-CM 36.07) and BMS (ICD-9-CM 36.06). We used logistic regression to model the odds of receiving a DES. Potential predictors included in the model were patient age, racial/ethnic-gender group (referent=White men), year, payer (referent=commercial), diabetes, atrial fibrillation (AFIB), chronic kidney disease (CKD), and end-stage renal disease (ESRD). Results: Among all STEMI patients, Hispanic women were most likely to receive a DES (61.2%) and Black men were least likely (46.8%). Furthermore, the % of patients who received no stent also varied from 6.7% among Hispanic men to 12.8% among Black women. Multivariable logistic regression results were highly significant, with included independent variables significantly predictive of the odds of receiving a DES in the expected directions. After adjustment and compared with White men, Hispanic women were 24% more likely to receive a DES (OR 1.24, 95%CI 1.13-1.37), White women were 8% more likely to receive a DES (p=0.001), and Black women were 15% less likely to receive a DES (OR 0.85, 95% CI 0.76-0.95). There were no significant differences in DES usage for Hispanic men or for men or women or “other” race/ethnicity. The strongest disparity was observed for Black men, who were 32% less likely to receive a DES than White men (OR 0.68, 95% CI 0.63-0.74, p&lt;0.0001). Conclusions: In this real-world analysis of unselected and recent STEMI patients, a significant disparity in use of DES for Black men and women was observed. This disparity was not explained by patient age, payer or comorbidities, nor by the secular trend.
Abstract 11299: Adiponectin at Physiologically Relevant Concentrations Fails to Induce Direct Vasorelaxation but Regulates the Balance Between Other Endogenous Vasoconstrictors and Vasodilators via Cav-1/AdipoR-1 Signaling
Authors: Yajing Wang, Jinjin Li, Rui Li, Gaizhen Liu, Wayne Bond Lau, Yuexing Yuan, Theodore Christopher, Bernard Lopez, Xin Ma
Journal: Circulation (2014)

The association between adiponectin (APN) and hypertension is evident in clinical studies, as hypoadiponectinema is an independent hypertension risk factor. Although supra-pharmacological APN causes direct vasodilation, the role of physiologic APN levels in vascular hemostasis remains unclear. The current study investigated the vaso-effect of physiologic APN concentrations upon Ang-II-induced vasoconstriction in mouse aortae. Consistent with previous reports, APN at supra-pharmacologic levels causes significant vasodilatation. However, physiologic APN concentrations (3-10 μg/ml) alone failed to cause significant arterial relaxation. Interestingly, pretreatment of aortae with physiologic APN levels significantly enhanced acetylcholine (ACh)-induced maximal vasodilatation (P<0.05) and decreased time to maximal vasorelaxation (P<0.05). A membrane-situated APN signalsome, containing APN receptor 1 (AdipoR1) and caveolin-1 (Cav-1), has been recently reported to facilitate APN signaling transduction. To evaluat...
Abstract 4297: Quantifying three-dimensional cellular morphology and its heterogeneity in epithelial cancers by single-cell optical tomography
Authors: Vivek Nandakumar, Stephanie Helland, Jessica H. Han, Geriann Davis, Brian A. Ashcroft, Thai H. Tran, Ting Li, Karen S. Anderson, Rahul Pannala, Joseph R. Mikhael, David E. Fleischer, Roger H. Johnson, Kimberly J. Bussey, Deirdre R. Meldrum
Journal: Cancer Research (2014)

Abstract The three-dimensional (3D) structure of the cell and its nucleus is intricately associated with cellular function. Aberrations and heterogeneity in cellular and nuclear morphology serve as diagnostically important cues to identify malignant transformation. However, current cytopathology practice is predominantly based on a qualitative, 2D assessment of cellular morphology that may bias the diagnosis. We utilized the Cell-CT® platform to perform single-cell, optical tomography imaging and generate 3D cell images with isotropic, sub-micron spatial resolution. We developed custom image analysis tools to accurately quantify 3D cell and nuclear morphology. We used these measures to characterize the morphological heterogeneity within and among epithelial cell populations, and to identify morphological descriptors that are reliably predictive of cell state. We assessed the efficacy of our approach relative to conventional 2D assessment (at 40x magnification) to detect malignant transformation in immortalized and primary normal-cancer cell line pairs from human esophagus and breast epithelia. We observed the 3D method of assessment to provide a consistently superior performance (sensitivity and specificity) in predicting malignant transformation. Further, some widely used diagnostic parameters, such as nuclear size or nucleus-to-cytoplasm ratio, did not always exhibit the highest predictive power in 3D space. The availability of 3D morphological information also provided novel insights on intra-population morphological heterogeneity in both normal and cancer cell populations. Our results emphasize the need to incorporate 3D morphological information into standard pathological practice. Citation Format: Vivek Nandakumar, Stephanie Helland, Jessica H. Han, Geriann Davis, Brian A. Ashcroft, Thai H. Tran, Ting Li, Karen S. Anderson, Rahul Pannala, Joseph R. Mikhael, David E. Fleischer, Roger H. Johnson, Kimberly J. Bussey, Deirdre R. Meldrum. Quantifying three-dimensional cellular morphology and its heterogeneity in epithelial cancers by single-cell optical tomography. [abstract]. In: Proceedings of the 105th Annual Meeting of the American Association for Cancer Research; 2014 Apr 5-9; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2014;74(19 Suppl):Abstract nr 4297. doi:10.1158/1538-7445.AM2014-4297
Soluble stem cell factor receptor (CD117) and IL-2 receptor alpha chain (CD25) levels in the plasma of patients with mastocytosis: relationships to disease severity and bone marrow pathology
Authors: Cem Akin, Lawrence B. Schwartz, Takashi Kitoh, Hirokazu Obayashi, Alexandra S. Worobec, Linda M. Scott, Dean D. Metcalfe
Journal: Blood (2000)
下肢肿痛-胸闷气短-意识丧失
Authors: 朱卫国, 曾学军
Journal: BMJ (2011)

患者女，53岁，因“下肢胀痛3个月，意识丧失1次”于2008年10月30日入院。患者3个月前无明显诱因渐起双下肢胀痛，左侧明显，活动后为著，伴午后低热、畏寒，无咳嗽、咳痰、咯血等。因症状加重，在当地接受针灸治疗共15d，无好转。
Monoclonal Lym-1 Antibody-Dependent Cytolysis by Neutrophils Exposed to Granulocyte-Macrophage Colony-Stimulating Factor: Intervention of FcγRII (CD32), CD11b-CD18 Integrins, and CD66b Glycoproteins
Authors: L. Ottonello, A.L. Epstein, P. Dapino, P. Barbera, P. Morone, F. Dallegri
Journal: Blood (1999)
Radiation Therapy and Risk of Cardiovascular Disease
Authors: Gabor Gyenes, George Gyenes
Journal: JAMA (2004)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
INFECTIOUS MONONUCLEOSIS: A CASE FOLLOWING A SKIN ABRASION ON THE RIGHT LEG, AND INVOLVING ONLY THE RIGHT INGUINAL LYMPH NODES
Authors: Norman Larue Anderson, Robert Humber Cox
Journal: Annals of Internal Medicine (1945)

Case Reports1 January 1945INFECTIOUS MONONUCLEOSIS: A CASE FOLLOWING A SKIN ABRASION ON THE RIGHT LEG, AND INVOLVING ONLY THE RIGHT INGUINAL LYMPH NODESNORMAN LARUE ANDERSON, M.D., ROBERT HUMBER COX, M.D.NORMAN LARUE ANDERSON, M.D.Search for more papers by this author, ROBERT HUMBER COX, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-22-1-118 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe following case report is presented not only because it is, we believe, the first reported case of infectious mononucleosis following a known skin lesion, but also because it may offer additional evidence concerning the nature of the disease.CASE REPORTThe patient was a 27 year old white male physician living in a rural community. On September 14, 1942, he noted a small, slightly tender indurated area on the skin covering the lower internal aspect of the right tibia. This area was surrounded by an ecchymotic zone measuring about 4 cm. in diameter. The patient did not remember the...Bibliography1. PAULBUNNELL JRWW: The presence of heterophile antibodies in infectious mononucleosis, Am. Jr. Med. Sci., 1932, clxxxiii, 90. CrossrefGoogle Scholar2. KRACKEGARVER RRHE: Diseases of the blood and atlas of hematology, 1937, J. B. Lippincott Company, Philadelphia, p. 390. Google Scholar3. STRAUSBERNSTEIN RMT: Further serologic studies in infectious mononucleosis, Am. Jr. Clin. Path., 1942, xii, 174-182. CrossrefGoogle Scholar4. NYFELDT A: Étiologie de la mononucléose infectieuse, Compt. rend. Soc. de biol., 1929, ci, 590. Google Scholar5. GORHAMSMITHHUNT LWDTHD: The experimental reproduction of the blood picture of infectious mononucleosis in the guinea pig, Jr. Clin. Invest., 1929, vii, 504. Google Scholar6. NETTLESHIP A: On infectious mononucleosis, Proc. Soc. Exper. Biol. and Med., 1942, xlix, 116. CrossrefGoogle Scholar7. BORNSTEIN S: Heterophile antibody reaction caused by bacterial infection, Ann. Int. Med., 1942, xvi, 472-479. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: *Received for publication April 3, 1943. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byInfectious Mononucleosis 1 January 1945Volume 22, Issue 1Page: 118-121KeywordsInfectious diseasesLesionsLymph nodesSkin infections ePublished: 1 December 2008 Issue Published: 1 January 1945 PDF downloadLoading ...
Guidelines for legal and financial counseling of Alzheimer's disease patients and their families
Authors: W Overman, A Stoudemire
Journal: American Journal of Psychiatry (1988)

As soon as there is reasonable evidence for the diagnosis of Alzheimer's disease (primary progressive degenerative dementia), the physician should urge legal and financial counseling of the patient and the family in planning for the patient's long-term care. The general purposes and the process of such counseling are described as a guide for physicians who care for these patients and their families. The issues of informed consent, competency, powers of attorney, guardianship, inter vivos trusts, wills, and living wills are discussed. Timely planning eases the burden on the family and assists the physician in the patient's care during the later stages of the disorder.
714. Structure-Based Engineering of the FokI DNA Cleavage Domain in the Context of a Chimeric Endonuclease: Towards Maximally Efficient “Gene Editing” Therapy
Authors: Jeffrey C. Miller, Michael Holmes, Fyodor Urnov, Andrew C. Jamieson, Carl O. Pabo
Journal: Molecular Therapy (2004)

Nucleases that introduce a double-strand break into a sequence of one's choosing for use in  editing  (Wilson, Nat. Biotech. 21: 759) can be created by fusing the cleavage domain of the type IIs restriction enzyme FokI to engineered zinc finger proteins (ZFPs). The FokI cleavage domain must dimerize in order to cleave DNA efficiently and therefore two different ZFP-FokI fusions are required to introduce a sequence-specific double-stranded break in a given locus. Creating FokI cleavage domain variants that do not function as homodimers would help ensure that these nucleases do not cleave unintended sites and thus enhance the specificity of the resulting proteins. Using structure-based design, we have created a FokI cleavage domain mutant that can cleave DNA efficiently when paired with a wild-type cleavage domain, but does not function when paired with itself. A second cleavage domain mutant was created that functions when paired with the first mutant, but does not function when paired with itself or with a wild-type cleavage domain. Preliminary experiments using a cell-based gene correction assay indicate that pairs of ZFPs containing these modified FokI cleavage domains robustly potentiate the correction of a chromosomally integrated GFP reporter inactivated with a nonsense mutation. Both proteins were inactive for targeting when used alone in a cellular context, illuminating the utility of a protein engineering approach in the context of a genome editing therapy protocol.
Abstract MP61: Dietary Fiber Intake and Mortality Among Myocardial Infarction Survivors
Authors: Shanshan Li, Alan Flint, Jennifer Pai, John Forman, Frank Hu, Walter Willett, Kathryn Rexrode, Kenneth Mukamal, Eric Rimm
Journal: Circulation (2014)

Background: Dietary fiber is associated with lower risk of coronary heart disease in healthy populations. It is unclear whether higher consumption of dietary fiber after myocardial infarction (MI) is associated with lower mortality. Objective: To evaluate the associations of dietary fiber post-MI and changes from pre- to post- with all-cause and cardiovascular mortality. Design: The Nurses’ Health Study (NHS) and the Health Professionals Follow-Up Study (HPFS) are two large prospective cohort studies of US women and men with repeated dietary measurements. We included 2,258 women and 1,840 men who were free of cardiovascular disease, stroke or cancer at enrollment, survived a first MI during follow up, were free of stroke at the time of initial MI onset, and provided both pre-MI and at least one post-MI food frequency questionnaire. We evaluated the associations of dietary fiber post-MI and changes from pre- to post- with all-cause and cardiovascular mortality using Cox proportional hazards models, adjusting for medication use, medical history, and lifestyles factors. Results: Higher post-MI fiber intake was significantly associated with lower all-cause mortality (Comparing extreme quintiles, pooled hazard ratio (HR) = 0.75, 95%CI: 0.58-0.97). Greater intake of cereal fiber was more strongly associated with all-cause mortality (Pooled HR=0.73, 95%CI: 0.58-0.91) than were other sources of dietary fiber. Increased fiber intake from pre- to post- was significantly associated with lower all-cause mortality (Pooled HR=0.69, 95%CI: 0.55-0.87). Conclusions: In this prospective study of MI survivors, greater post-MI intake of dietary fiber, especially cereal fiber, was inversely associated with all-cause mortality. In addition, increasing consumption of fiber from pre- to post-MI periods was significantly associated with lower all-cause and cardiovascular mortality.
Abstract P046: Association of Stromal Derived Factor 1 (SDF1) and Transforming Growth Factor ß1 (TGFß1) with Incident Hypertension: The Multi-Ethnic Study of Atherosclerosis (MESA)
Authors: Cecilia Berardi, James S Pankow, Michael Y Tsai, Michele Sale, Mariza de Andrade, Hugues Sicotte, Weihong Tang, Naomi Hanson, Paul A Decker, Phillip S Kirsch, Christina Wessel, Suzette J Bielinski
Journal: Circulation (2014)

Incident hypertension varies across races/ethnicities. Mechanisms implicated in the pathogenesis are endothelial dysfunction with reduction of nitric oxide and alterations of the Renin-Angiotensin-Aldosterone System (RAAS). Stromal Derived Factor 1 (SDF1) and Transforming Growth Factor β1 (TGFβ1) are essential in these processes. SDF1 is a chemotactic protein that regulates migration of endothelial progenitor cells from the bone marrow to the arterial wall to repair endothelial damage; TGFβ1 promotes extra-cellular matrix deposition within arterial vessels, inhibits nitric oxide production and stimulates renin release. In order to investigate the association of circulating levels of these proteins with incident hypertension across different ethnicities, an ethnic stratified random sample of 2,880 participants from the Multi-Ethnic Study of Atherosclerosis (MESA) was used. Of those, 988 participants had available plasma samples and were without hypertension, defined as blood pressure ≥ 140/90 mmHg, or current use of antihypertensive medications, at baseline. During a median follow up of 8.5 years, 388 new cases of hypertension (101 in non-Hispanic whites, 94 in Chinese, 101 in African Americans and 92 in Hispanics) were observed. Time to hypertension incidence was estimated using Cox proportional hazards regression. Hazard Ratios were adjusted for age, sex, diabetes, LDL, HDL, triglycerides, BMI, smoking status and current alcohol use. The race/ethnicity by protein interaction p-values were 0.055 and 0.066 for TGFβ1 and SDF1 respectively, suggesting heterogeneity across races/ethnicities. In Chinese, a difference of one standard deviation of plasma TGFβ1 was associated with a 22% increase in incident hypertension (HR (95% CI) 1.22 (1.02, 1.47), p-value=0.03); and a difference of one standard deviation of plasma SDF1 was associated with a 31% decrease in incident hypertension (HR (95% CI) 0.69 (0.52, 0.91), p-value 0.008). No significant association was found between these proteins and incident hypertension among non-Hispanic whites, African or Hispanic Americans. In conclusion, soluble markers of endothelial integrity and of RAAS activation were associated with the incidence of hypertension among Chinese Americans. These results suggest heterogeneity in the pathophysiology of hypertension according to race/ethnicity.
Inhibition of the PI3K/Akt/mTOR pathway abrogates laminin-mediated SCLC survival and resistance to Gleevec
Authors: Junji Tsurutani, Kip A. West, Jacqueline Sayyah, Phillip A. Dennis
Journal: Cancer Research (2004)

1461  Small cell lung cancer (SCLC) is commonly incurable despite being initially responsive to chemotherapy. Extracellular matrix (ECM) can promote chemotherapeutic resistance in SCLC cells, but the mechanism connecting adhesion to ECM to therapeutic resistance is unknown. To address this, we cultured a series of SCLC cell lines on plastic dishes or plastic dishes coated with purified laminin, collagen I, collagen IV, or fibronectin, and compared activation of two signaling pathways that can promote cellular survival, the PI3K/Akt/mTOR pathway and the MEK/ERK pathway. Laminin activated both pathways in H69, H345 and H510 cells. Adhesion to laminin increased cellular survival after serum starvation, and caused the cells to separate and assume a flattened, epithelial morphology. To determine the roles of the PI3K/Akt or MEK/ERK pathways after adhesion to laminin, we treated laminin-adherent H69 cells with small molecule inhibitors and assessed survival. Inhibitors of the PI3K/Akt/mTOR pathway (LY294002 or rapamycin), but not the MEK/ERK pathway (U0126), abrogated laminin-mediated survival. SCLC cells plated on laminin were not only resistant to serum starvation-induced apoptosis, but were also resistant to apoptosis caused by the PDGFR/c-kit antagonist, Gleevec. Combining Gleevec with either LY294002 or rapamycin, but not U0126, caused greater than additive increases in apoptosis, compared to apoptosis caused by the inhibitor or Gleevec when used singly. These results were confirmed by inhibiting the PI3K/Akt/mTOR pathway with adenoviruses expressing dominant negative Akt (DNM Akt). DNM Akt abrogated laminin-mediated survival and laminin-induced resistance to Gleevec. Together, these studies identify laminin-mediated activation of the PI3K/Akt/mTOR pathway as a mechanism of cellular survival and chemotherapeutic resistance in SCLC cells, and suggest that combinations of signal transduction inhibitors could overcome chemotherapeutic resistance mediated by ECM.
Expression of matrix metalloproteinases and their tissue inhibitors in the serum and cerebrospinal fluid of patients with meningitis
Authors: H.‐C. Tsai, M.‐H. Shi, S. S.‐J. Lee, S.‐R. Wann, M.‐H. Tai, Y.‐S. Chen
Journal: Clinical Microbiology and Infection (2010)
An Occupational Analysis of 580 Cardiac Clinic Patients
Authors: Adult Cardiac Clinic
Journal: Circulation (1951)

This report, the first of a series, presents a fairly detailed analysis of the occupational status of a group of cardiac clinic patients as found at a single point of time. An analysis of this type sheds little or no light on the effects of occupation on the course of heart disease, but it does give some indication of the extent to which cardiacs can carry on useful activities.
Abstract 18045: Stem Cell Impregnated Nanofiber Stent Sleeve for Intravascular Paracrine Factor Production
Authors: Chao-Wei Hwang, Peter V Johnston, Zhiyong Xia, Virginia Bogdan, Gordon F Tomaselli, Robert G Weiss, Gary Gerstenblith
Journal: Circulation (2014)

Background: Results of stem cell studies for cardiomyopathy and peripheral artery disease are promising, but benefits remain modest in part due to cell washout and immune attack. Evidence suggests that many stem cell effects are paracrine-mediated, wherein secreted factors activate intrinsic repair. We now describe a stem cell impregnated nanofiber (NF) stent sleeve in which a biodegradable NF sleeve is electrospun around a stent and impregnated with a large number of stem cells. The porous sleeve nanostructure prevents cell washout and immune attack, and allows sustained local production and secretion of stem cell paracrine factors. Methods: NF stent sleeves are created by electrospinning poly-lactic-co-glycolic acid (PLGA) co-polymer onto expanded stents. Sleeves are impregnated with stem cells in a 1.2 mL solution of 3.2x10 6 mesenchymal stem cells (MSCs). Sleeve nanostructure was examined by electron microscopy. MSC adhesion and viability in the sleeve were assessed on days 1 and 8 using a fluorescent cell viability assay. VEGF and HGF secretion was quantified by ELISA over 7 days. Biological activity of sleeves with MSCs was determined by HUVEC tubule formation on day 8 and compared to sleeves without MSCs. Results: Stent sleeves consist of randomly oriented NFs (A) uniformly covering the stent (B) onto which MSCs readily attached. MSCs proliferated normally, remained CD90+ and CD44+, and were confluent on day 8 (C,D) with more than 90% viability. VEGF and HGF (E,F) continued to be secreted, and sleeves with MSCs induced HUVECs to organize into tubules to a 3.1±0.7 fold greater extent than control. NF sleeves can be crimped onto angioplasty balloons and delivered via 8F catheters. Conclusion: Our results demonstrate the engineering feasibility of a stem cell impregnated NF stent sleeve, and pave the way for animal studies to assess the efficacy of local paracrine factor production and delivery to treat cardiomyopathy and peripheral artery disease.