PRELIMINARY REPORT ON THE BENEFICIAL EFFECT OF CHLOROMYCETIN IN THE TREATMENT OF TYPHOID FEVER
Authors: T E WOODWARD, J E SMADEL
Journal: Annals of Internal Medicine (1948)

Article1 July 1948PRELIMINARY REPORT ON THE BENEFICIAL EFFECT OF CHLOROMYCETIN IN THE TREATMENT OF TYPHOID FEVERTHEODORE E. WOODWARD, M.D., JOSEPH E. SMADEL, M.D., HERBERT L. LEY JR., M.D., RICHARD GREEN, M.D., D. S. MANKIKAR, M.D.THEODORE E. WOODWARD, M.D., JOSEPH E. SMADEL, M.D., HERBERT L. LEY JR., M.D., RICHARD GREEN, M.D., D. S. MANKIKAR, M.D.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-29-1-131 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptA new antibiotic Chloromycetin has been clinically tested in the treatment of typhoid fever and has been found to exhibit significant chemotherapeutic effects. A description of the results in 10 cases is submitted as a preliminary report.Chloromycetin is a crystalline substance obtained through processes of concentration and purification of cultures in liquid media of a Streptomyces sp. originally isolated by Burkholder,†and shown by him to possess anti-bacterial activity. Ehrlich and associates1in the Research Laboratories of Parke, Davis and Company carried out studies of the antibiotic activity of this Streptomyces which led to preparation of the crystalline antibiotic...Bibliography1. EHRLICHBARTZSMITHJOSLYNBURKHOLDER JQRRMDAPR: Chloromycetin, a new antibiotic from a soil actinomycete, Science, 1947, cvi, 417. CrossrefGoogle Scholar2. SMITHJOSLYNGRUHZITMCLEANPENNEREHRLICH RMDAOMIWMAJ: Chloromycetin: biological studies, Jr. Bact., 1948, lv, 425-47. CrossrefGoogle Scholar3. SMADELJACKSON JEEB: Chloromycetin, an antibiotic with chemotherapeutic activity in experimental rickettsial and viral infections, Science, 1947, cvi, 418. CrossrefGoogle Scholar4. SMADELLEÓNLEYVARELA JEHEHLG: Chloromycetin in the treatment of patients with typhus fever, Proc. Soc. Exper. Biol. and Med. In press. Google Scholar5. PAYNEKNAUDTPALACIOS EHJAS: Treatment of epidemic typhus with Chloromycetin, Jr. Trop. Med. and Hyg., 1948, li, 68. Google Scholar6. SMADELWOODWARDLEYPHILIPTRAUBLEWTHWAITESAVOOR JETEHLCBRRSR: Chloromycetin in the treatment of scrub-typhus. (Read before the International Congress for Tropical Disease, Washington, D. C., May 11, 1948.) Science. In press. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: *Received for publication May 16, 1948.From The Department of Medicine, University of Maryland, School of Medicine; The Department of Virus and Rickettsial Diseases, Army Medical Department of Research and Graduate School; the Commission on Immunization of the Army Epidemiology Board; and from The Institute for Medical Research, Kuala Lumpur, Malaya.†Dr. Paul R. Burkholder, Osborn Botanical Laboratory, Yale University. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byS. 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BRODERICKTyphoid fever in fourteen children treated with chloramphenicolCHLORAMPHENICOL IN TYPHOID FEVERTREATMENT OF TYPHOID FEVER WITH CHLORAMPHENICOLCHLORAMPHENICOL IN TYPHOID FEVEREosinophils and Surgical ShockChloromycetin in Typhoid FeverTyphoid and paratyphoid fever: A review of four cases treated with chloromycetinTyphoid fever in an infant complicated by typhoid meningitisChloromycetin in the Treatment of Salmonella EnteritisTreatment of Typhoid Fever with ChloromycetinChloromycetin in Typhoid Fever and Other Salmonella InfectionsAcute Enteric InfectionsRELAPSE IN TYPHOID FEVER AFTER TREATMENT WITH CHLORAMPHENICOLChloramphenicol (chloromycetin) in the treatment of infectious diseasesCases Presented at Conferences at the St. Louis Children's Hospital During 1949CHLOROMYCETIN IN THE TREATMENT OF TYPHOID FEVER FOURTEEN CASES TREATED IN THE MIDDLE EASTTreatment of Typhoid Fever with ChloromycetinChloromycetin in the Successful Treatment Of Recurring Epididymitis 1EXPERIMENTAL TYPHOID INFECTION TREATED WITH CHLOROMYCETIN AND SULPHADIAZINEThe Specific Treatment of Typhoid FeverTyphoid and the Paratyphoids: A ReviewIn vitro effects of chloromycetin on Malayan bacteriaTyphoid fever treated with chloromycetinAntibiotic Therapy of Typhoid FeverCHLOROMYCETIN IN TYPHOID FEVERNew antibioticsAchievements with ChloromycetinCHLORAMPHENICOL (CHLOROMYCETIN) IN EXPERIMENTAL CHOLERA INFECTIONSAntibacterial ChemotherapyChloromycetinChloromycetin 1 July 1948Volume 29, Issue 1Page: 131-134KeywordsAntibioticsAttentionEpidemiologyGraduate medical educationResearch laboratoriesTyphoid ePublished: 1 December 2008 Issue Published: 1 July 1948 PDF downloadLoading ...