tbuckley/cabot-search huggingface dataset:
Right ventricular mechanics: a comparison of models
Authors: T. SUND, H. PIENE
Journal: Cardiovascular Research (1983)

Using data from an isolated supported cat right ventricle preparation, we investigated the following models or methods for characterising the mechanical function of the ventricle: (1) a pressure generator in series with an internal impedance; (2) a variable elastance in series with an internal, pressure dependent flow resistance; (3) pulse response analyses, theoretically based on the pressure response to a small volume step of short duration; and (4) geometric mapping of the variables pressure and volume as functions of time. We tested the reproductive and predictive strengths of the four models, and found that all methods could reproduce 50% of the observed pressure curves with an RMS error less than 0.2 kPa, and in most cases also gave a close prediction of pressure curves which were not used to establish the respective model parameters. We see this as one reason for the fact that no single ventricular model has yet been universally accepted.
Alterations in nuclear scaffold constituents during carbon tetrachloride–induced liver regeneration
Authors: Gary A. Clawson, Kenneth R. Madsen, Lori J. Blankenship, Christine L. Hatem
Journal: Hepatology (1991)

Liver regeneration was induced in rats by treatment with CCl4, which results in substantial regenerative activity with a sharp mitotic response 2 days after intoxication. Closely paralleling the mitotic index, we observed fourfold increases in nuclear scaffold nucleoside triphosphatase, an activity thought to participate in nucleocytoplasmic RNA transport and in the 46 kD putative enzyme and its selective photolabeling. Because previous work has indicated that the 46 kD protein may be proteolytically derived from lamins A/C by cleavage at a tyrosine residue at aa376, we investigated the response of lamin A/C transcripts during this regeneration. Surprisingly, Northern blot analyses after CCl4 administration showed low levels of lamin A/C transcripts (which appeared to be predominantly poly[A]-), and we found a decrease in immunoprecipitable lamins A/C from in vitro translation of poly(A)- selected RNA. To circumvent potential problems with such analyses, we used reverse transcription/polymerase chain reaction amplification of lamin A/C transcripts from total cytoplasmic RNA. These assays showed a transient, comparatively minor increase in lamin A/C transcripts 1 day after treatment, but levels rapidly declined from 1 to 3 days and were decreased at 3 to 5 days. However, nuclear scaffold protease activity, which shows a considerable selectivity for lamins A/C and may be involved in derivation of the 46 kD protein, increased in parallel to the mitotic response and increases in nucleoside triphosphatase, as assessed using a nonspecific (Azocoll) protease assay. Assays with a specific tyrosine-containing substrate (Z-Y-Sbenzyl) showed an increase that mirrored that observed with the nonspecific substrate.(ABSTRACT TRUNCATED AT 250 WORDS)
Abstract 3151: Molecular and clinicopathological impact of miR-375 deregulation in prostate cancer
Authors: Elke Nolte, Sven Wach, Robert Stoehr, Arndt Hartmann, Jaroslaw Szczyrba, Friedrich Graesser, Wolf Wieland, Bernd Wullich, Helge Taubert
Journal: Cancer Research (2012)

Abstract Background: Prostate cancer is a leading cause of tumor mortality. In order to identify the underlying mechanisms we have analyzed microRNA (miRNA) expression profiles of primary prostate cancers and non-cancer prostate tissue. As recently reported by our group, miR-375 was found to be upregulated in prostate cancer using deep sequencing and microarray analyses. We now set out to study whether there is an association between miR-375 expression and the expression of different gene members of the epithelial-mesenchymal transition (EMT) pathway. Material and Methods: Expression of miR-375 and genes of the EMT pathway (ZEB1, ZEB2, N-Cadherin) was measured by qRT-PCR in 26 pairs of prostate cancer and corresponding non-tumor prostate tissue. Bivariate correlation analyses of miR-375 and EMT members as well as for miR-375 and clinicopathological features were carried out. Results: MiR-375 showed a significant upregulation in prostate cancer using qRT-PCR (p=0.0019, paired student's t-test), whereas ZEB1, ZEB2, and N-Cadherin were consistently found downregulated (p&amp;lt;0.05, paired student's t-test). Applying bivariate correlation analysis, a negative correlation of miR-375 expression to N-Cadherin, ZEB1, and ZEB2 could be documented (p&amp;lt;0.05, Spearman Rho test). Furthermore, we could detect an inverse correlation of miR-375 expression to patient age (p=0.002, Spearman Rho test). Remarkably, miR-375 expression higher than median is significantly correlated to a lower tumor grade (p=0.011, Fisher's exact test). Conclusion: Expression of miR-375 is inversely correlated to the expression of N-Cadherin, ZEB1, and ZEB2. As SLUG is the only member of the EMT pathway, which is a predicted target of miR-375, we suppose SLUG to constitute the putative link between miR-375 and EMT. Furthermore, our findings show that expression of miR-375 is correlated with patient age and tumor grade. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 103rd Annual Meeting of the American Association for Cancer Research; 2012 Mar 31-Apr 4; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2012;72(8 Suppl):Abstract nr 3151. doi:1538-7445.AM2012-3151
Abstract 4164: HBx induced IGF-II expression is essential for hepatic dysplasia formation in mice
Authors: Hye-lin Ha, Hye–Jun Shin, Dae-Yuel Yu
Journal: Cancer Research (2010)

Abstract HCC is one of the most common cancers in the world. Chronic infection with HBV considered as a major risk factor. Among the four proteins from the HBV genome, HBx is a multifunctional regulatory protein which has been reported to be linked with hepatocellular carcinogenesis. We reported HBx induces liver cancer in transgenic mice. Among the multistep progress of liver carcinogenesis, enlargement (dysplasia) of the liver considered most critical point of this progression. HBx mice showed dysplasia within 4 weeks, dysplastic nodules and HCA after 6 months and HCC after 9 months of age. In this point we found out different expression pattern of IGF-II in HBx liver compare to wild type. In general this protein hormone predominantly active in fetal liver is strictly down-regulated shortly after birth. HBx mice have an increased liver/body weight ratio as well as cyclinD1 expression compared to wild type mice after 2 weeks. At that point, highly expressed IGF-II in wild mice started to decrease but in HBx mice the IGF-II expression still remained high level. The HBx-HepG2 cell line also has a higher expressed IGF-II level than the Mock-HepG2 cell line. Like in vivo data, the HBx cell line showed fast growth and increased cyclinD1 expression levels. Furthermore we found that abnormal cell growth was inhibited by neutralizing secreted IGF-II in vitro system with treatment of IGF-II antibody. In conclusion, we suggest IGF-II leads to liver dysfunction via over-proliferation of an HBx damaged hepatocyte. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 101st Annual Meeting of the American Association for Cancer Research; 2010 Apr 17-21; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2010;70(8 Suppl):Abstract nr 4164.
Basophil degranulation induced by cigarette smoking in man.
Authors: S Walter, A Walter
Journal: Thorax (1982)

There is some evidence that histamine could be a mediator of the immediate broncho-constriction that follows cigarette smoking. Since the chief reservoir of histamine in normal human blood is the basophil, we studied the acute effects of cigarette smoking on these cells. Capillary blood samples were obtained from 27 healthy young male smokers, before and 10 minutes after smoking. Basophils were collected and concentrated from these samples by a millipore membrane filter technique, stained with toluidine blue, and classified according to the staining characteristics and location of their cytoplasmic granules. This classification differentiated the "intact" from the "degranulated" basophils. A significant increase in degranulated cells and decrease in intact cells (p less than 0.001) was observed after smoking. Since histamine is present in the basophil granules, these findings suggest that cigarette smoking causes histamine release.
B lymphocyte immune response gene phenotype is genetically determined.
Authors: H Y Tse, J J Mond, D L Longo
Journal: The Journal of Experimental Medicine (1982)

We examined the effects of the developmental milieu on the capacity of B cells to undergo immune response gene-controlled, T cell-dependent polyclonal proliferation. Although I-Aq poly(Glu60 Ala30 Tyr10)n (GAT)-nonresponder T cells developing in a responder environment become phenotypic GAT-responders, I-Aq B cells remain unresponsive to GAT, even after maturation in a GAT-responder animal. Conversely, (B10.A x B10.Q)F1 ([GAT responder x GAT nonresponder]F1) T cells developing in a B10.Q GAT nonresponder host fail to respond to GAT, but F1 B cells from the same F1 leads to parent chimeras make excellent proliferative responses in the presence of GAT and responder T cells. Thus, by this assay, B cell immune response gene function is genetically determined and is not affected by the developmental milieu.
Thank You to the<i>JAMA Surgery</i>Peer Reviewers, Authors, and Readers
Authors: Melina R. Kibbe
Journal: JAMA Surgery (2015)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Surgery HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Surgery journal
Diet, Lifestyle, and Longevity—The Next Steps?
Authors: Eric B. Rimm
Journal: JAMA (2004)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
A clinicopathologic study of patients with hemorrhagic myocardial infarction treated with selective coronary thrombolysis with urokinase.
Authors: H Fujiwara, T Onodera, M Tanaka, T Fujiwara, D J Wu, C Kawai, Y Hamashima
Journal: Circulation (1986)

Hemorrhagic acute myocardial infarction (AMI) was studied after selective intracoronary thrombolysis (SICT) in 30 patients undergoing autopsy. Urokinase, 240,000 to 1,200,000 U, was selectively injected into the infarct-related coronary artery at 2 to 9 hr (4 +/- 2 hr) after the onset of AMI. The infarct-related coronary artery showed complete occlusion in 21, 99% stenosis in eight, and 90% stenosis in one patient before SICT. After SICT, complete occlusion was seen in only five, 99% stenosis in 22, and 90% stenosis in three patients. Twenty-eight patients had transmural infarction and the other two had subendocardial infarction. Macroscopically and microscopically, the degree of hemorrhage was classified as no, slight, moderate, or marked bleeding and the hemorrhagic infarction was defined as moderate or marked diffuse bleeding in the infarct area. According to the interval from SICT to death, patients were also classified into stage I (early acute stage, 1 to 4 hr after SICT and 4 to 13 hr after the onset of AMI; n = 7), stage II (late acute stage, 9 hr to 11 days after SICT and 15 hr to 11 days after the onset of AMI; n = 18), or stage III (old infarction stage, over 17 days after AMI and SICT; n = 5). There were no significant differences with respect to the frequency of recanalization, the time from the onset of AMI to SICT, the dose of urokinase, or other clinical parameters among patients at the three stages. Only the hearts of patients in stage II showed hemorrhagic infarction, and it was found in 15 of 18 of these hearts.(ABSTRACT TRUNCATED AT 250 WORDS)
Acute adrenal failure secondary to bilateral infarction of the adrenal glands as the first manifestation of primary antiphospholipid antibody syndrome
Authors: I MARIE, H LEVESQUE, F HERON, N CAILLEUX, J Y BORG, H COURTOIS
Journal: Annals of the Rheumatic Diseases (1997)

Adrenal insufficiency is an uncommon, life threatening complication of the primary antiphospholipid antibody syndrome (PAPS), secondary to either adrenal haemorrhage or infarction.1-6Adrenal failure more often follows other PAPS thromboembolic manifestations, and has to be clearly differentiated from other PAPS abdominal emergencies, including mesenteric and hepatic infarction.1 3-5 The pathological mechanisms involved are still not clearly understood, but the hypercoagulable state in patients with PAPS supports the concept that adrenal haemorrhagic infarction may possibly be related to adrenal vein thrombosis.7 We recently observed a new case, which is of particular interest as the patient developed an acute adrenal failure, revealing bilateral adrenal infarction, as a first manifestation of the PAPS.

A 70 year old patient presented with diffuse abdominal pain persisting for 15 days. He had no …
Goiter and Renal Failure
Authors: GERHARD BAUMANN
Journal: Annals of Internal Medicine (1974)

Comments1 November 1974Goiter and Renal FailureGERHARD BAUMANN, M.D., KONSTANTIN NEUHAUS, M.D., HEINRICH THÖLEN, M.D.GERHARD BAUMANN, M.D.Search for more papers by this author, KONSTANTIN NEUHAUS, M.D.Search for more papers by this author, HEINRICH THÖLEN, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-81-5-706_1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: In a recent paper Ramírez and collaborators (Ann Intern Med 79:500-504, 1973) report the frequent occurrence of goiter in patients undergoing hemodialysis treatment, but the cause of this finding remains unelucidated.We have examined 77 patients consecutively admitted with preterminal and terminal renal failure, 52 of whom participated in the hemodialysis program.Causes of renal disease included chronic pyelonephritis, obstructive uropathy, malignant hypertension, chronic glomerulonephritis, and diabetic glomerulosclerosis. The presence or absence and size and consistency of goiter was determined by careful palpation by two independent observers. Size was classified according to the World Health Organization classification...References1. PÉREZ C, SCRIMSHAW N, and MOÑOZ J: Endemic Goiter, in World Health Organization Monograph Series No. 44, Geneva, 1960, p. 369 Google Scholar2. GYR N: Der Einfluss der Jodsalzprophylaxe auf die Gesamtzahl der Kropfoperationen in der Schweiz im Zeitraum von 1945 bis 1961. Schweiz Rdsch Med 53:1382-1387, 1964 Google Scholar3. MERKE F: Weshalb unser Jodsalz am 1. September 1962 endlich höher jodiert wurde. Schweiz Rdsch Med 53:1388-1393, 1964 Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: GERHARD BAUMANN, M.D.; KONSTANTIN NEUHAUS, M.D.; HEINRICH THÖLEN, M.D.Affiliations: Department of Medicine Kantonsspital University of Basel Medical School Basel Switzerland PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 November 1974Volume 81, Issue 5 Page: 706-706 Keywords Global health Glomerulonephritis Hypertension Patients Pyelonephritis Renal diseases Renal failure ePublished: 1 December 2008 Issue Published: 1 November 1974 PDF downloadLoading ...
Multiple Sclerosis: A Reappraisal
Authors: Kenneth R. Magee
Journal: JAMA (1965)

Physicians who have read the 1955 edition of<i>Multiple Sclerosis</i>by McAlpine, Compston, and Lumsden might think that this new book represents merely a revision of the earlier work. They would be incorrect. Although some information is repeated, the greater part of the text has been completely altered and expanded. Describing it as a new book is justified, as is the new subtitle "A Reappraisal." All aspects of multiple sclerosis are considered. Not only are current knowledge and theories evaluated, but areas for future study are suggested. Three major sections form the book. The first, by Acheson, considers the epidemiology of multiple sclerosis and includes a critical analysis of the problems of interpreting epidemiologic studies. The second section, by McAlpine, reviews clinical studies and will be of particular interest to the clinician. The natural history, early symptoms and signs, difficulties in diagnosis, course, prognosis, treatment, and socioeconomic problems are presented.
Abstract 4080: TGF-β Effects on prostate cancer cell migration are mediated by PGE2 through activation of PI3K/AKT/mTOR pathway.
Authors: Baohan T. Vo, Derrick Morton, Shravan Komaragiri, Ana C. Millena, Shafiq A. Khan
Journal: Cancer Research (2013)

Abstract Transforming growth factor-beta (TGF-β) plays an important role in the progression of prostate cancer. It exhibits both tumor suppressor and tumor promoting activities. Correlations between COX-2 overexpression and enhanced production of PGE2 have been implicated in cancer progression; however, there are no studies indicating that TGF-β effects in prostate cancer cells involve PGE2 synthesis. In this study, we investigated TGF-β regulation of COX-1 and COX-2 expression in prostate cancer cells and whether the effects of TGF-β on cell proliferation and migration are mediated by PGE2. COX-1 protein was ubiquitously expressed in prostate cells; however, COX-2 protein levels were only detected in prostate cancer cells. TGF-β treatment increased COX-2 protein levels and PGE2 secretion in PC3 cells. Exogenous PGE2 and PGF2α had no effects on cell proliferation in LNCaP, DU145, and PC3 cells while PGE2 and TGF-β induced migratory behavior only in PC3 cells. Only EP2 and EP4 receptors were detected at mRNA levels in prostate cells. The EP4-targeting siRNA inhibited PGE2 and TGF-β-induced migration of PC3 cells. PGE2 and TGF-β induced phosphorylation of AKT which was blocked by antagonists of PGE2 (EP4) receptors (L161982, AH23848) and PI3-kinase inhibitor (LY294002) in PC3 cells. Pretreatment with L161982 or AH23848 blocked the stimulatory effects of PGE2 and TGF-β on cell migration, while LY294002 or rapamycin completely eliminated PGE2, TGF-β, and EGF-induced migration PC3 cells. We conclude that TGF-β increases COX-2 levels and PGE2 secretion in prostate cancer cells which, in turn, mediates TGF-β effects on cell migration through the activation of PI3K/AKT/mTOR pathway. Acknowledgements: These studies were supported by the NIH/NIMHD/RCMI grant #G12MD007590, NIH/NIMHD #5P20MD002285, and DOD grant # W8I-08-1-0077. Citation Format: Baohan T. Vo, Derrick Morton, Shravan Komaragiri, Ana C. Millena, Shafiq A. Khan. TGF-β Effects on prostate cancer cell migration are mediated by PGE2 through activation of PI3K/AKT/mTOR pathway. [abstract]. In: Proceedings of the 104th Annual Meeting of the American Association for Cancer Research; 2013 Apr 6-10; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2013;73(8 Suppl):Abstract nr 4080. doi:10.1158/1538-7445.AM2013-4080
National Study of U.S. Emergency Department Visits With Diabetic Ketoacidosis, 1993–2003
Authors: Adit A. Ginde, Andrea J. Pelletier, Carlos A. Camargo
Journal: Diabetes Care (2006)

Patients with diabetic ketoacidosis (DKA) are often managed in the emergency department before hospital admission. DKA hospitalizations comprise a significant portion of health care costs for diabetes (1). Although mortality for DKA has fallen, it remains an important cause of diabetes-associated death, especially among younger patients with diabetes (2). Prior analyses of DKA have been single-center intensive care unit (ICU) studies or based on hospital discharges (3–5). Patients may, however, be treated in the emergency department and then admitted to a non-ICU setting or discharged; the frequency of these practices is not known. We sought to describe the epidemiology of emergency department visits with DKA.

We analyzed the emergency department component of the 1993–2003 U.S. National Hospital Ambulatory Medical Care Survey (NHAMCS). Our institutional review board waived review of this analysis. Methodological details are described elsewhere (6–8). Briefly, NHAMCS uses a four-stage sampling strategy covering geographic primary sampling units, hospitals within primary sampling units, emergency departments within hospitals, and patients within emergency departments. Hospitals were stratified by region, presence of emergency department, ownership type, and size. Within each stratum, hospitals were selected with a probability proportional to the number of emergency department visits. Data were collected during randomly …
Effect of Cesarean Section on Neonatal Body Water Spaces
Authors: George Cassady
Journal: New England Journal of Medicine (1971)

Abstract Body water spaces in 16 vaginally delivered, mature neonates and 17 infants delivered by cesarean section were estimated by in vivo dilution studies within 19 hours of birth. A significant increase in mean total water was noted in the infants delivered by cesarean section (about 250 ml per 3.2-kg  study baby). This excess water was primarily intracellular, representing an average 20 per cent expansion of cell water in the neonate. A significant decline in cell water was observed in the vaginally delivered neonates within eight hours of birth. Although a similar trend was noted in those delivered by cesarean section the magnitude of the decline was considerably less.