tbuckley/cabot-search huggingface dataset:
BLOOD PRESSURE STUDIES ON UNIVERSITY STUDENTS, INCLUDING THE EFFECT OF EXERCISE ON ESSENTIAL HYPERTENSION, HYPOTENSION, AND NORMAL SUBJECTS
Authors: E. A. Thacker
Journal: Annals of Internal Medicine (1940)

Article1 September 1940BLOOD PRESSURE STUDIES ON UNIVERSITY STUDENTS, INCLUDING THE EFFECT OF EXERCISE ON ESSENTIAL HYPERTENSION, HYPOTENSION, AND NORMAL SUBJECTSE. A. THACKER, M.S., M.D.E. A. THACKER, M.S., M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-14-3-415 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptIt is evident from the accumulation of articles in the scientific literature, that many factors influence the level of blood pressure. However, with our present knowledge, the cause of essential high and low blood pressures remains quite obscure.The purpose of this investigation has been to study the normal and abnormal blood pressures among university students and to ascertain the effect of exercise upon them from a comparative standpoint. A history and physical examination are obtained on each entering student. This study included the observation of 15,500 male students at the University of Illinois from 1935 to 1939. Those...Bibliography1. HINESBROWN EAGE: The cold pressor test for measuring reactibility of blood pressure, Am. Heart Jr., 1936, xi, 1. CrossrefGoogle Scholar2. THACKER EA: A comparative study of normal and abnormal blood pressures to the cold pressor test among university students, Am. Heart Jr., 1940, xx, 89. CrossrefGoogle Scholar3. HINESBROWN EAGE: The hereditary factor in the reaction of blood pressure to a standard stimulus, Proc. Staff Meet. Mayo Clin., 1932, vii, 332. HINES, E. A.: Hereditary factor in essential hypertension, ANN. INT. MED., 1937, xi, 593. Google Scholar4. RIESMAN D: Hypertension, ANN. INT. MED., 1937, xi, 335. LinkGoogle Scholar5. GROLLMAN A: Physiological variations in cardiac output of man, Am. Jr. Physiol., 1929, lxxxix, 584. CrossrefGoogle Scholar6. ZIPF K: Chemical nature of "depressor substance" in blood formerly designated as "early toxin": identity with adenylic acid, Arch. f. exper. Path. u. Pharmakol., 1931, clx, 579. CrossrefGoogle Scholar7. GOERNERHALEY AFL: Nature of depressor substance in hepatic extract, Jr. Lab. and Clin. Med., 1929, xiv, 1047. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: New Orleans, Louisiana*Received for publication April 9, 1940.From the University of Illinois Health Service Department, Urbana. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited bySystolic hypertensionThe occurrence of paroxysmal hypertension in patients with intermittent claudication 1 September 1940Volume 14, Issue 3Page: 415-423KeywordsBlood pressureExerciseHypertensionHypotensionMedical servicesObservational studies ePublished: 1 December 2008 Issue Published: 1 September 1940 PDF downloadLoading ...
An Experimental Study in the Domain of Hypnotism.
Authors: Richard von Krafft-Ebing
Journal: JAMA (1889)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
768. Activity of the Extracellular Domain of the Coxsackie and Adenovirus Receptor
Authors: Katherine J. D. A. Excoffon, Geri L. Traver, Nicholas Gansemer, Joseph Zabner
Journal: Molecular Therapy (2004)

The Coxsackie virus and Adenovirus Receptor (CAR) plays a dual role as a viral receptor and a homotypic junctional adhesion protein. CAR is a transmembrane protein and a member of the Immunoglobulin superfamily with two extracellular Ig-like domains. According to x-ray crystallographic data, the most distal Ig-like domain (D1) mediates the homophilic interaction. This same domain is also responsible for the high affinity binding of the adenovirus (Ad) fiber protein. Currently no activity has been ascribed to the proximal Ig-like domain (D2). We asked whether the D2 domain plays a role in the function of CAR as either a viral receptor or an adhesion protein.
The Last Stage
Authors: Floyd Skloot
Journal: JAMA (2001)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
A 6-month maintenance therapy with adapalene-benzoyl peroxide gel prevents relapse and continuously improves efficacy among patients with severe acne vulgaris: results of a randomized controlled trial
Authors: Y. Poulin, N.P. Sanchez, A. Bucko, J. Fowler, M. Jarratt, S. Kempers, N. Kerrouche, J.-C. Dhuin, R. Kunynetz
Journal: British Journal of Dermatology (2011)

Journal Article A 6‐month maintenance therapy with adapalene‐benzoyl peroxide gel prevents relapse and continuously improves efficacy among patients with severe acne vulgaris: results of a randomized controlled trial Get access Y. Poulin, Y. Poulin Centre de Recherche Dermatologique du Québec Metropolitan, Quebec City, QC, Canada Yves Poulin. E‐mail: poulinyves@videotron.ca Search for other works by this author on: Oxford Academic Google Scholar N.P. Sanchez, N.P. Sanchez Sanchez Dermatology, Aibonito, Puerto Rico Search for other works by this author on: Oxford Academic Google Scholar A. Bucko, A. Bucko Academic Dermatology Associates, Albuquerque, NM, U.S.A. Search for other works by this author on: Oxford Academic Google Scholar J. Fowler, J. Fowler Dermatology Specialists, Louisville, KY, U.S.A. Search for other works by this author on: Oxford Academic Google Scholar M. Jarratt, M. Jarratt DermResearch, Inc., Austin, TX, U.S.A. Search for other works by this author on: Oxford Academic Google Scholar S. Kempers, S. Kempers Minnesota Clinical Study Center, Fridley, MN, U.S.A. Search for other works by this author on: Oxford Academic Google Scholar N. Kerrouche, N. Kerrouche Galderma R&D, Sophia‐Antipolis, France Search for other works by this author on: Oxford Academic Google Scholar J.‐C. Dhuin, J.‐C. Dhuin Galderma R&D, Sophia‐Antipolis, France Search for other works by this author on: Oxford Academic Google Scholar R. Kunynetz R. Kunynetz Ultranova Skincare, Barrie, ON, Canada Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 164, Issue 6, 1 June 2011, Pages 1376–1382, https://doi.org/10.1111/j.1365-2133.2011.10344.x Published: 01 June 2011
Biological effects of recombinant human granulocyte colony-stimulating factor in patients with untreated acute myeloid leukemia
Authors: MR Baer, SH Bernstein, VL Brunetto, K Heinonen, K Mrozek, VL Swann, H Minderman, AW Block, LA Pixley, NP Christiansen, JW Fay, M Barcos, Y Rustum, GP Herzig, CD Bloomfield
Journal: Blood (1996)
Professor Al Aynsley-Green
Authors: Katherine Burke
Journal: BMJ (2004)

Health tsars: spin or substance?: Eight health directors (“tsars”) were appointed from 1999 to 2002. Katherine Burke asked them to summarise their achievements and other people to assess their work. A ninth “tsar”, Dr Sue Roberts, was appointed in March 2003 to cover diabetes. The full text is accessible at www.bmj.com
An occupational hazard: A patient's choice
Authors: S. Power
Journal: BMJ (1999)

He would always say it was an occupational hazard. From the age of 16, Norman helped freight goods across the deepest seas this world has to offer. He did it with friends and an awful lot of alcohol. Cheap alcohol.

During his leave he would stay with his sister (my mother) and her family (the rest of us). In all the years he lived with me, I never once saw him drunk. Locally, his tolerance for it was legendary.

One …
Abstract 13431: Global Longitudinal Strain Combined With Radial Strain Delay Before Cardiac Resynchronization Therapy is Associated With Long Term Survival
Authors: Antonia Delgado-Montero, Bhupendar Tayal, Keiko Ryo, Akiko Goda, David Schwartzman, Samir Saba, John Gorcsan
Journal: Circulation (2014)

Introduction: Identifying factors related to nonresponse in cardiac resynchronization therapy (CRT) remains clinically important. The interaction of factors of global longitudinal strain (GLS), as an associated marker of scar burden, and radial strain delay, as a mechanical dyssynchony marker remains unclear. Hypothesis: Our aim was to test the hypothesis that GLS by speckle tracking echocardiography (STE) combined with positive radial strain delay have prognostic utility in CRT patients. Methods: We studied 128 heart failure patients with routine CRT indications according to current clinical guidelines (ischemic 68%, age 64.9 ± 11.7 years, QRS width 159.3 ± 29.5 ms, left ventricular (LV) ejection fraction (EF) 23.9 ± 5.4%). GLS was determined with speckle tracking as the average of the segmental values from routine 2D apical views. Baseline radial strain delay was assessed by speckle tracking radial strain with positive (+) pre-defined as anteroseptal to posterior wall delay ≥130 ms. Response was defined...
Social Support, Personal Control, and Psychological Functioning Among Individuals with Heart Failure
Authors: Melissa Virginia Taylor
Journal: Circulation (2005)

Heart failure, a serious and prevalent chronic disease, places a large psychosocial burden on patients and their families. The research presented in this dissertation focuses on the complex relationship between social support and personal control and two key psychological outcomes— depression and anxiety—in individuals coping with heart failure. Theoretically defensible models are developed, drawing on an integrative stress coping framework, and appropriate inferential statistical procedures are implemented to identify the importance of the proposed relationships in a sample of 242 adult men and women being treated for cardiomyopathy. Two structural models are evaluated. Model 1 examines the mediating influence of personal control between social support and depression, while Model 2 examines the mediating influence of control between social support and anxiety. Statistically significant estimates indicate that social support plays a key role in reducing psychological distress—depressive symptoms and anxiety. The mechanism whereby social support effectively reduces psychological distress is entirely through patients' perceived control. An additional objective of the study is exploration of gender differences in the two models. A series of empirical analyses, using path analysis and regression-based mediation models, indicate that among heart failure patients there are indeed statistically significant gender differences in the relationships between social support, control, and psychological functioning. These differences were contingent on the measurement of control included in the model. Evidence suggests that the role of social support is greater for women than for men in reducing psychological distress, as indicated by either depressive symptoms or anxiety.
New approach to treating rheumatoid arthritis shows promise
Authors: Scott Gottlieb
Journal: BMJ (2000)

People with early stages of rheumatoid arthritis seem to have fewer symptoms and less rapid progression of joint damage when they are treated with drugs that block the protein that promotes inflammation, known as tumour necrosis factor.

Two new studies show that two tumour necrosis factor inhibitors, infliximab and etanercept, seem to do as good or better a job of treating rheumatoid arthritis than methotrexate, which is the current standard of care ( New England Journal of Medicine 2000;343:1586-93, 1594-1602).

In the first study, directed by Dr Joan M Bathon of Johns Hopkins University, Baltimore, Maryland, 632 patients with early rheumatoid arthritis received subcutaneous etanercept (10 mg or 25 mg) twice weekly or oral methotrexate (mean 19 mg weekly) for 12 months.

Clinical response was defined as the percentage improvement in disease activity according to the criteria of the American College of Rheumatology. Bone erosion and narrowing of joint spaces were measured radiographically and scored using …
Evidence gaps in the management of sickle cell disease: A summary of needed research
Authors: William J. Savage, George R. Buchanan, Barbara P. Yawn, Araba N. Afenyi‐Annan, Samir K. Ballas, Jonathan C. Goldsmith, Kathryn L. Hassell, Andra H. James, Joylene John‐Sowah, Lanetta Jordan, Richard Lottenberg, M. Hassan Murad, Eduardo Ortiz, Paula J. Tanabe, Russell E. Ware, Sophie M. Lanzkron
Journal: American Journal of Hematology (2015)
Erratum: Corrigendum: Multigenerational epigenetic adaptation of the hepatic wound-healing response
Authors: Müjdat Zeybel, Timothy Hardy, Yi K Wong, John C Mathers, Christopher R Fox, Agata Gackowska, Fiona Oakley, Alastair D Burt, Caroline L Wilson, Quentin M Anstee, Matt J Barter, Steven Masson, Ahmed M Elsharkawy, Derek A Mann, Jelena Mann
Journal: Nature Medicine (2012)
Abstract 3966: PLK1 regulates PAX3-FOXO1 stability and its inhibition mediates regression of alveolar rhabdomyosarcoma xenograft tumors
Authors: Verena Thalhammer, David Herrero-Martin, Regina Hecker, Dominik Laubscher, Laura Lopez-Garcia, Marco Wachtel, Peter Bode, Beat Schäfer
Journal: Cancer Research (2014)

Abstract Oncogenic addiction provides an opportunity to develop new treatment options, especially for childhood cancers. Pediatric tumors contain a lower number of oncogenic mutations compared to most adult cancers, suggesting stronger dependency on individual oncogenes, such as chimeric transcription factors that have the ability to control multiple oncogenic pathways. Taking advantage of this addiction, targeting of oncogenic transcription factors becomes a new powerful strategy for therapy of translocation positive pediatric tumors like alveolar rhabdomyosarcoma (aRMS), which is characterized by a very dismal prognosis. As transcription factors are considered to be difficult to target, we developed an approach to screen for druggable upstream regulators like kinases. In two parallel activity reporter assays, using a kinome siRNA library and a small molecule library, we identified PLK1 to contribute to the activity of PAX3-FOXO1, the oncogenic transcription factor specific to aRMS. Mechanistically, we were able to demonstrate a direct interaction of the two proteins by co-immunoprecipitation. PLK1 silencing or inhibition increased degradation of PAX3-FOXO1, which suggests a stabilization of PAX3-FOXO1 due to phosphorylation by PLK1. Candidate phosphorylation sites were identified by in vitro kinase assays and mass spectrometric analysis and site-specific mutagenesis is currently utilized to validate the impact of these sites on fusion protein turnover. To highlight PLK1 as therapeutic target in aRMS, in vivo treatment studies using the PLK1 inhibitor BI 2536 resulted in complete tumor regression in two aRMS xenograft mouse models. Finally, tissue microarray analysis of human aRMS tumor biopsies showed PLK1 to be overexpressed and predictive of overall survival. Hence, our preclinical studies validate PLK1 as highly relevant drug target in alveolar rhabdomyosarcoma, similar to recent findings in other pediatric tumors. Our data suggests that PLK1 inhibitors warrant further investigations to evaluate the potential to be translated into a clinical setting. Citation Format: Verena Thalhammer, David Herrero-Martin, Regina Hecker, Dominik Laubscher, Laura Lopez-Garcia, Marco Wachtel, Peter Bode, Beat Schäfer. PLK1 regulates PAX3-FOXO1 stability and its inhibition mediates regression of alveolar rhabdomyosarcoma xenograft tumors. [abstract]. In: Proceedings of the 105th Annual Meeting of the American Association for Cancer Research; 2014 Apr 5-9; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2014;74(19 Suppl):Abstract nr 3966. doi:10.1158/1538-7445.AM2014-3966
Genomic structure of the gene for mouse germ cell nuclear factor (GCNF)
Authors: Ute Süsens, Uwe Borgmeyer
Journal: Genome biology (2000)

The germ cell nuclear factor (GCNF, also known as retinoid acid receptor-related testis-associated receptor, neuronal cell nuclear receptor or NR6A1) is an orphan receptor in the nuclear receptor superfamily found in mammals, amphibians and fish. The mouse Gcnf gene is expressed in the placenta and the developing nervous system and germ cells, and responds to retinoic acid.We have defined the intron-exon structure of the mouse Gcnf gene and found that it contains 11 exons. Exons 1-4 encode the 75 amino acid amino-terminal domain and exon 4 also encodes the core DNA-binding domain. The carboxy-terminal extension is encoded by exon 5, exons 6 and 7 encode the hinge region, and exons 7-11 encode the putative ligand-binding domain. Unusually, the two zinc-finger motifs in the DNA-binding domain are encoded by separate exons.The protein-coding region of GCNF is contained in 11 exons. The genomic structure of this nuclear receptor gene will be useful for further studies.
Abstract P387: Race and Sex Differences Exist in the Volumes of Visceral Adipose Tissue Associated With Prevalent Hypertension in Middle Age Adults
Authors: Christina M Shay, Prasenjeet N Motghare, David R Jacobs, Cora E Lewis, J. Greg Terry, J. Jeffrey Carr
Journal: Circulation (2014)

Background: Higher visceral adipose tissue (VAT) volume is associated with greater risk for hypertension (HTN). Although VAT volume and prevalence of HTN vary by sex and race, the differences in VAT volumes associated with identification of individuals with prevalent HTN across these groups is unclear. Objective: To determine VAT volume cut points that maximize true positive, true negative and optimal identification of prevalent HTN and to compare the cut points across sex and race groups. Methods: Data were examined from the Coronary Artery Risk Development in Young Adults (CARDIA) study, a multi-center longitudinal study of the development of cardiovascular risk in black and white men and women ages 18-30 years at baseline. In 2010-11, the Year 25 exam was performed (43-55 years) and VAT volume (cm3) was quantified by computed tomography based on two 5 mm contiguous slices at the level of the 4th-5th lumbar vertebra (n=3,153). HTN was defined as systolic blood pressure ≥140 mmHg, diastolic blood pressure ≥90 mmHg and/or anti-hypertension medication use. Receiver operating characteristic (ROC) curve analysis was used to identify VAT volume cut points associated with true positive, true negative and optimal identification of prevalent HTN. Results: Year 25 prevalence of HTN ranged from 18.2% (white women) to 49.4% (black women); mean VAT volume ranged from 113.5 cm3 (white women) to 172.1 cm3 (white men). White males exhibited the highest VAT volumes (22-36% higher) and black women exhibited the lowest VAT volumes (3-50% lower) associated with true positive, true negative and optimal identification of HTN compared to other race/sex groups (Table 1). VAT volumes associated with HTN among black participants were generally lower than those exhibited for whites. Conclusions: Although the utility of VAT alone to identify HTN cases is modest - likely a result of unaccounted HTN confounders - these findings display the distinct race- and sex-specific differences in VAT volumes associated with prevalent HTN in middle age adults.
Errors in the Recognition and Treatment of Heart Disease
Authors: R. BRUCE LOGUE, J. WILLIS HURST
Journal: Circulation (1954)

T HE medical literature is replete with communications on heart disease.De- spite this abundant literature, errors are made in recognizing and treating diseases of the heart.This report describes some of the more common errors encountered in practice and offers certain clues that may be helpful in pre- venting some of the mistakes.
Abuse of Iodin, Especially of Iodized Salt, in The Prevention of Goiter
Authors: C. L. Hartsock
Journal: Annals of Internal Medicine (1927)

Article1 July 1927Abuse of Iodin, Especially of Iodized Salt, in The Prevention of GoiterC. L. HARTSOCK, M.D.C. L. HARTSOCK, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-1-1-24 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptIt may seem presumptious for me to attempt to discuss any phase of the relation of iodin to goiter at this time, when such an authority as Dr. Marine is to talk to you on the same subject, but my reason for doing so is that 15 percent of the total number of patients admitted to the Cleveland Clinic are goiter patients, and it is from the observation and study of this large group of cases that we have reached certain conclusions regarding the use of iodin in the various phases of this disease.As the result of the extensive...(1) BIRCHER E: Iodin treatment of goiter, Klin. Wchnschr., 1925, iv, 742-745. CrossrefGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Cleveland Clinic Cleveland, Ohio*Clinical discussion given before the American College of Physicians at the Cleveland Clinic, February 22-25, 1927. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byAssociation of Iodine Fortification with Incident Use of Antithyroid Medication—A Danish Nationwide StudyReappraisal of the risk of iodine-induced hyperthyroidism: An epidemiological population surveyIodine-Induced Hyperthyroidism: Occurrence and EpidemiologyThe treatment of hyperthyroidism in children and younger adolescentsDer Jodgehalt von Jodspeisesalzen des Handels 1 July 1927Volume 1, Issue 1Page: 24-27KeywordsArmed forcesObservational studiesSalts ePublished: 1 December 2008 Issue Published: 1 July 1927 PDF downloadLoading ...