tbuckley/cabot-search huggingface dataset:
Correlates of benefit from induction chemotherapy before radiotherapy in non-small cell lung cancer (NSCLC): A meta-analytical approach with meta-regression analysis
Authors: H. S. Bozcuk, M. Ozdogan, M. Artac, M. Yildiz
Journal: Journal of Clinical Oncology (2008)

7575 Background: Sequential chemoradiotherapy, a treatment approach reserved generally for patients not suitable for concomitant chemoradiotherapy improves survival over radiotherapy only in non-small cell lung cancer (NSCLC). We wanted to assess the predictors of this benefit from induction chemotherapy before radiotherapy in NSCLC. Methods: Electronic databases and relevant reviews were searched for published randomized clinical trials that compared induction chemotherapy with no treatment, administered before radiotherapy. Relative risk (RR) was employed to define the risk of death at 2 and 3 years, by using Mantel Haenszel method in fixed and random effects models. Additionally, meta-regression analysis was used to assess correlates of benefit from induction chemotherapy. Results: 13 relevant randomized clinical trials to date, encompassing 2776 patients, were identified. The addition of induction chemotherapy decreased the risk of mortality, both at 2 and 3 years. With the random model, the associated RRs were 0.91 at 2 years (P < 0.001) and 0.94 at 3 years (P = 0.001). Interestingly, time to radiotherapy was inversely associated with the benefit from induction chemotherapy at 2 (t = 1.90, P = 0.093) and 3 years (t = 2.42, P = 0.036). No other trial, disease, patient and treatment characteristics as evaluated in this meta-analysis were associated with the magnitude of benefit from induction chemotherapy. Conclusions: Sequential chemoradiotherapy is superior to radiotherapy alone in NSCLC. In this setting, shorter time to radiotherapy after the onset of induction chemotherapy appears to be linked with greater benefit from induction chemotherapy. However, further research is still necessary to optimize the use of induction chemotherapy in conjunction with radiotherapy. No significant financial relationships to disclose.
Curbing Medicalese is the issue
Authors: David J Ogden
Journal: BMJ (2007)

The stability of housekeeping genes (HKGs) is critical when performing real-time quantitative PCR. To date, the stability of common HKGs has not been systematically compared in human airway epithelial cells (AEC) in normal and atopic subjects. Expression levels of 12 HKGs were measured in AECs from a cohort of 30 healthy atopic nonasthmatic or atopic asthmatic children. Gene expression stability was determined using three different Visual Basic for Applications applets (geNorm, NormFinder and BestKeeper). All 12 HKGs were expressed in AECs. However, the hypoxanthine ribosyltransferase and TATA-binding protein genes were excluded from further analysis due to low expression levels. The cyclophilin A gene was ranked the most stable by all three methods. The expression levels of the β-actin and glyceraldehyde-3-phosphate dehydrogenase genes were significantly different between the three groups of patients, with atopic asthmatics showing the highest expression levels for both genes. The results suggest that the cyclophilin A gene is the most suitable housekeeping gene analysed for expression studies utilising uncultured bronchial airway epithelial cells from healthy and asthmatic children, and highlight the importance of validating housekeeping genes for each experimental model.
Rezulin Labeling Updated to Recommend More Frequent Patient Monitoring
Authors: Stuart L. Nightingale
Journal: JAMA (1998)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Anti-Rabies Vaccine of Tissue Culture Origin
Authors: R E KISSLING, D R REESE
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
A photic visual cycle of rhodopsin regeneration is dependent on Rgr
Authors: Pu Chen, Wenshan Hao, Lawrence Rife, Xiao Peng Wang, Daiwei Shen, Jeannie Chen, Thomas Ogden, Gretchen B. Van Boemel, Lanyin Wu, Mao Yang, Henry K.W. Fong
Journal: Nature Genetics (2001)
Interest in physician-assisted suicide among ambulatory HIV-infected patients
Authors: W Breitbart, B D Rosenfeld, S D Passik
Journal: American Journal of Psychiatry (1996)

This study surveyed HIV-infected patients' attitudes toward physician-assisted suicide and examined the relationship between interest in physician-assisted suicide and physical and psychosocial variables.Three hundred seventy-eight ambulatory HIV-infected patients, 90% of whom met the criteria of the Centers for Disease Control for AIDS, were recruited from several sites in New York City. Self-report measures were used to assess pain, physical symptoms, psychological distress, depression, and social supports. Attitudes toward, and interest in, physician-assisted suicide were assessed through responses to a questionnaire.Sixty-three percent of the patients supported policies favoring physician-assisted suicide, and 55% acknowledged considering physician-assisted suicide as an option for themselves. The strongest predictors of interest in physician-assisted suicide were high scores on measures of psychological distress (depression, hopelessness, suicidal ideation, overall psychological distress) and experience with terminal illness in a family member or friend. Other strong predictors were Caucasian race, infrequent or no attendance at religious services, and perceived low level of social supports. Interest in physician-assisted suicide was not related to severity of pain, pain-related functional impairment, physical symptoms, or extent of HIV disease.HIV-infected patients supported policies favoring physician-assisted suicide at rates comparable to those in the general public. Patients' interest in physician-assisted suicide appeared to be more a function of psychological distress and social factors than physical factors. These findings highlight the importance of psychiatric and psychosocial assessment and intervention in the care of patients who express interest in or request physician-assisted suicide.
Abstract B08: New Abelson interactor-1(Abi-1)-driven mechanism of acquired drug resistance
Authors: Anna Chorzalska, Ibrahem Salloum, Philip Marjon, Diana Treaba, Christoph Schorl, Morgan John, Christine R. Bryke, John Reagan, Eric Winer, Adam J. Olszewski, Patrycja M. Dubielecka
Journal: Clinical Cancer Research (2015)

Abstract In hematological malignancies, quiescent leukemic stem cells are responsible for persistence of minimal residual disease and relapse. We have recently identified a new signaling pathway that is significantly dysregulated in imatinib mesylate (IM) resistant leukemic cells (Chorzalska et all, Leukemia in press). A key player in this pathway is Abelson interactor-1 (Abi-1). Abi-1 was originally identified as Abl kinase associating protein that was later confirmed to be one of the Bcr-Abl interactors. Abi-1 was recently shown to interact directly with α4 integrin, which controls lodging of hematopoietic and leukemic stem cells (HSCs/LSCs) in the bone marrow microenvironment. We have recently obtained evidence that Abi-1 plays a role in signaling cross-talk between Bcr-Abl and α4 integrin. We have found that loss of Abi-1 leads to increased adhesion and quiescence, resulting in increased chemoresistance of leukemic CD34+ progenitor cells. Comparison of Abi-1 (ABI-1) and α4 integrin (ITGA4) gene expression in relapsing Bcr-Abl positive CD34+ progenitor cells demonstrated a reduction in Abi-1 and an increase in α4 integrin mRNA in the absence of Bcr-Abl mutations. This inverse correlation between Abi-1 and α4 integrin expression, as well as linkage to elevated phospho-Akt and phospho-Erk signaling, was confirmed in imatinib mesylate (IM) resistant leukemic cells. These results indicate that the α4-Abi-1 signaling pathway may mediate acquisition of the drug resistant phenotype of leukemic cells. Based on our findings, we hypothesize that chemoresistance arises as a consequence of dysregulation of a pathway involving α4 integrin and Abi-1, and is mediated through a previously unknown mechanism that is independent of oncogene activity. Citation Format: Anna Chorzalska, Ibrahem Salloum, Philip Marjon, Diana Treaba, Christoph Schorl, Morgan John, Christine R. Bryke, John Reagan, Eric Winer, Adam J. Olszewski, Patrycja M. Dubielecka. New Abelson interactor-1(Abi-1)-driven mechanism of acquired drug resistance. [abstract]. In: Proceedings of the AACR Precision Medicine Series: Drug Sensitivity and Resistance: Improving Cancer Therapy; Jun 18-21, 2014; Orlando, FL. Philadelphia (PA): AACR; Clin Cancer Res 2015;21(4 Suppl): Abstract nr B08.
Kozmetiklerle ilişkili alerjik yama test reaksiyonları: 2 1-2 4 yılları arasında Kuzey Amerika Kontakt Dermatit Grubu'nun çapraz kesitli verilerinin retrospektif analizi
Authors: Erin M. Warshaw, Heather J. Buchholz, Donald V. Belsito, Howard I. Maibach, Joseph F. Fowler, Robert L. Rietschel, Kathryn A. Zug, C. G. Toby Mathias, Melanie D. Pratt, Denis Sasseville, Frances J. Storrs, James S. Taylor, Vincent A. DeLeo, James G. Marks
Journal: Journal of the American Academy of Dermatology (2009)
PROCEEDINGS OF AMERICAN RHEUMATISM ASSOCIATION, ATLANTIC CITY, JUNE 8, 1942: ABSTRACTS AND DISCUSSIONS OF PAPERS: EPIDEMIC RHEUMATIC FEVER
Authors: Paul L. Boisvert, M. Henry Dawson, Francis F. Schwentker, James D. Trask
Journal: Annals of Internal Medicine (1943)

Article1 July 1943PROCEEDINGS OF AMERICAN RHEUMATISM ASSOCIATION, ATLANTIC CITY, JUNE 8, 1942EPIDEMIC RHEUMATIC FEVER†PAUL L. BOISVERT, M.D., M. HENRY DAWSON, M.D., FRANCIS F. SCHWENTKER, M.D., JAMES D. TRASK, M.D.PAUL L. BOISVERT, M.D.Search for more papers by this author, M. HENRY DAWSON, M.D.Search for more papers by this author, FRANCIS F. SCHWENTKER, M.D.Search for more papers by this author, JAMES D. TRASK, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-19-1-107_1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptEpidemic rheumatic fever is not a new disease but it does have especial importance in times, such as these, when large numbers of men are concentrated in military cantonments. The term, epidemic rheumatic fever, apparently implies more than is intended. It is used to indicate the presence of a significant number of cases under, as you might say, one roof. If rheumatic fever were a reportable disease in civilian life, it might be found that there would be considerable variations in its incidence from year to year.Rheumatic fever is an important military disease and its presence offers a new... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: *Received for publication December 30, 1942.†These investigations were aided through the Commission on Streptococcal Infections, Board for the Investigation and Control of Influenza and Other Epidemic Diseases in the Army, Preventive Medicine Service, Office of the Surgeon General, United States Army.‡Deceased. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 July 1943Volume 19, Issue 1Page: 107-107KeywordsArmed forcesPreventive medicineRheumatic feverStreptococcal infectionsSurgeons Issue Published: 1 July 1943 PDF downloadLoading ...
Abstract 16029: Activator of G-Protein Signaling 8, an Ischemia-Inducible G-Protein Activator, is Required for Vascular Endothelial Growth Factor-Mediated Collateral Development
Authors: Hisaki Hayashi, Abdullah A Mamun, Miho Sakima, Hiroko Suzuki, Motohiko Sato
Journal: Circulation (2014)

Ischemia elicits multiple events in the heart, including myocardial cell death and coronary collateral development. These events are mediated by G-protein coupled receptors, but are also regulated by receptor-independent activators of heterotrimeric G-proteins. We previously identified one such regulatory protein, activator of G-protein signaling 8 (AGS8), from a rat heart with substantial collaterals following repetitive transient ischemia. AGS8 is up-regulated in response to hypoxia/ischemia and directly interacts with Gβγ. AGS8 plays a pivotal role in the hypoxia-induced apoptosis of cardiomyocytes by regulating Gβγ signaling. However, the role of AGS8 in collateral development has not previously been investigated. Here, we examine the role of AGS8 in endothelial cells by siRNA-mediated knockdown of AGS8. AGS8-siRNA inhibited HUVEC tube formation on fetal calf serum-stimulated matrigel (23.3 ± 2.9% of control, p<0.01, mean±SEM). Vascular endothelial growth factor (VEGF)-induced endothelial cell tube fo...
Sodium taurocholate cotransporting polypeptide (SLC10A1) deficiency: Conjugated hypercholanemia without a clear clinical phenotype
Authors: Frédéric M. Vaz, Coen C. Paulusma, Hidde Huidekoper, Minke de Ru, Cynthia Lim, Janet Koster, Kam Ho‐Mok, Albert H. Bootsma, Albert K. Groen, Frank G. Schaap, Ronald P. J. Oude Elferink, Hans R. Waterham, Ronald J.A. Wanders
Journal: Hepatology (2014)

The enterohepatic circulation of bile salts is an important physiological route to recycle bile salts and ensure intestinal absorption of dietary lipids. The Na + ‐taurocholate cotransporting polypeptide SLC10A1 (NTCP) plays a key role in this process as the major transporter of conjugated bile salts from the plasma compartment into the hepatocyte. Here we present the first patient with NTCP deficiency, who was clinically characterized by mild hypotonia, growth retardation, and delayed motor milestones. Total bile salts in plasma were extremely elevated (up to 1,500 μM, ref. &lt;16.3) but there were no clinical signs of cholestatic jaundice, pruritis, or liver dysfunction. Bile salt synthesis and intestinal bile salt signaling were not affected, as evidenced by normal plasma 7α‐hydroxy‐4‐cholesten‐3‐one (C4) and FGF19 levels. Importantly, the presence of secondary bile salts in the circulation suggested residual enterohepatic cycling of bile salts. Sequencing of the SLC10A1 gene revealed a single homozygous nonsynonymous point mutation in the coding sequence of the gene, resulting in an arginine to histidine substitution at position 252. Functional studies showed that this mutation resulted in a markedly reduced uptake activity of taurocholic acid. Immunofluorescence studies and surface biotinylation experiments demonstrated that the mutant protein is virtually absent from the plasma membrane. Conclusion : We describe the identification of NTCP deficiency as a new inborn error of metabolism with a relatively mild clinical phenotype. The identification of NTCP deficiency confirms that this transporter is the main import system for conjugated bile salts into the liver but also indicates that auxiliary transporters are able to sustain the enterohepatic cycle in its absence. (H epatology 2015;61:260–267)
On the way to Calvary
Authors: R. Klein, A. Maynard
Journal: BMJ (1998)

What is surprising about the government's plans for the reform of the NHS in England is not what is in the white paper1 but what is omitted. The white paper was a triumph of style over content, which temporarily convinced a sympathetic profession and the wider public that all would be well for the NHS under Labour. Now the presentational triumph is over, come the pains of implementation, and ministers may find that they have unintentionally nailed themselves to a cross. For what is implicit in the white paper, but not spelt out, is that if the policies outlined in it are to succeed central government will have to play a more active role, managing and directing change.

The Conservative reforms of 1991 were intended to diffuse blame to the market. In practice, politics dragged ministers back, as the market was never allowed free play. The new Labour plans will, in contrast, focus on ministers. For implicit in the white paper is a command and control model of central management which …
Lokal İleri Evre ve Metastatik Prostat Kanserinde Aralıklı Androjen Çekilme Tedavisi: Güney Avrupa Üroonkoloji Grubunun Randomize Faz 3 Çalışmasına Ait Sonuçlar
Authors: Fernando E.C. Calais da Silva a, Aldo V. Bono, Peter Whelan, Maurizio Brausi, Anton Marques Queimadelos, Jose A. Portillo Martin, Ziya Kirkali, Fernando M.V. Calais da Silva, Chris Robertson
Journal: European Urology (2009)
369. Selective Expansion of Human T Lymphocytes Transduced by HIV Vectors Containing IMPDH2 and Anti-HIV siRNA Genes
Authors: Priscilla Yam, Ying Yu, Jerry Wu, Michael C. Jensen, John A. Zaia, Jiing-Kuan Yee
Journal: Molecular Therapy (2004)

To achieve effective protection of T cells from HIV infection using gene therapy approaches, a sufficient number of T cells expressing anti-HIV gene(s) are required. However, vectors derived from Moloney murine leukemia virus or human immunodeficiency virus (HIV) are relatively inefficient at delivering foreign genes into hematopoietic stem cells (HSCs) from which the genetically modified T cells could be derived. In this study, we evaluated a mutated human type II inosine-5′ monophosphate dehydrogenase (IMPDH2) for its ability to confer cell resistance to drugs such as mycophenolic acid (MPA) and its precursor mycophenolate mofetil (MMF) (Serrano et al. Mol Therapy 3:S152, 2001). The safety profile of these drugs in clinics may allow direct selection and expansion of the transduced T cell in vivo. The cDNA for the mutant IMPDH2, with two amino acid substitutions, was placed under the control of the promoter of Rous sarcoma virus (RSV) and inserted into pHIV7, a 3rd generation HIV vector containing the GFP gene. H9 cells were transduced with the IMPDH2 vector and selected in the following escalating doses of MPA: 3, 6, 12, 18 and 24 × 10−6 M for 24 days. The viability at these doses was 94, 94, 71, 51 and 12%, respectively, whereas cells transduced with a control GFP vector were eliminated at all doses. The percentage of GFP increased from 5.2% before drug selection to 90–97% after drug selection, suggesting that IMPDH2 could serve as an effective selection marker for the transduced cells. To treat HIV infection, we evaluated a small interfering RNA (siRNA) specific against the p24 coding region for its ability to down-regulate HIV replication. A hairpin p24 siRNA gene was placed under the control of the H1 promoter and inserted into pHIV7. H9 cells were transduced with this vector and challenged with NL4-3 at different doses. Our results showed an effective inhibition of HIV replication, from 2 to 6 log reduction, by the p24 siRNA for up to 30 days after challenge in culture. The IMPDH2 cDNA was then inserted into the vector containing the siRNA gene and the effect of drug selection on protection of the transduced cells from HIV infection is under investigation.
Juvenile pemphigus foliaceus
Authors: None Mehravaran, None Morvay, None MolnÁR, None OLÁH, None Korom, None Husz, None Dobozy
Journal: British Journal of Dermatology (1998)

A 7‐year‐old girl with generalized erythematous, scaling plaques and vesiculobullous lesions on the extremities was diagnosed as having pemphigus foliaceus. Lesional direct immunofluorescence revealed intercellular IgG, IgA and C3 deposition. The patient's serum gave positive reactions against one epitope of desmoglein 3 and the epitope of desmoglein 1 in enzyme‐linked immunosorbent assays, but the blood sample for indirect immunofluorescence did not display any circulating antibodies. The patient was successfully treated systemically with prednisolone and dapsone. Currently, she is taking dapsone, 12.5 mg daily. She has been free of lesions for the last 3 years.
Margaret A. Hamburg, MD, Reflects on 6 Years at FDA
Authors: Rita Rubin
Journal: JAMA (2015)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal