tbuckley/cabot-search huggingface dataset:
N-Acetylaspartylglutamate
Authors: Suzannah Bliss Tieman
Journal: JAMA (1988)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The optimal strategy for treating calcified lesions in large vessels: Comparison of intravascular ultrasound results of rotational atherectomy + adjunctive PTCA, DCA, or Stents
Authors: Gaston R. Dussaillant, Gary S. Mintz, Augusto D. Pichard, Kenneth M. Kent, Lowell F. Satler, Jeffrey J. Popma, Carol Walsh, Paul Mackel, Jennifer Griffin, Kathy Morgan, Tammy Weaver, Martin C. Leon
Journal: Journal of the American College of Cardiology (1996)
Causes and Consequences of Placental Growth Retardation
Authors: Richard L. Naeye
Journal: JAMA (1978)

Placental growth retardation caused 84 fetal and neonatal deaths per 100,000 births. Its frequency increased as mothers' diastolic blood pressure levels increased, an effect augmented by proteinuria. The perinatal deaths also increased with advancing maternal age, anemia, and poverty. Maternal weight gains were low in the involved pregnancies, and the fetuses and neonates who died had a pattern of growth retardation characteristic of fetal undernutrition. Microscopic abnormalities in the decidua and placenta were characteristic of inadequate perfusion of the placenta from the uterus. They included fibrinoid changes in the arteries and arterioles of the decidua, villous cytotrophoblastic hyperplasia, and an obliterative endarteritis in fetal stem arteries of the placenta. (<i>JAMA</i>239:1145-1147, 1978)
Two years results of lamivudine (LMV) alone and LMV plus interferon (IFN) treatment in children with chronic hepatitis B (CHB) who were non-responders to IFN
Authors: I.N. Saltik Temizel, N. Kocak, H. Demir, H. Ozen, F. Gurakan, A. Yuce
Journal: Journal of Hepatology (2003)
Abstract 3325: Role of AP2A1 in EGFR nuclear translocation and transcriptional activation activity
Authors: Huai-Gu Chen, Sheng-Chieh Hsu
Journal: Cancer Research (2014)

Abstract The tyrosine kinase activity and endocytosis of epidermal growth factor receptor (EGFR) are activated by ligand binding. The adaptor protein 2 (AP2) complex found in the clathrin coated vesicles mediates intracellular trafficking of EGFR. Accumulating evidence suggest that the nucleus is one of intracellular destination. Nuclear EGFR severs as a transcriptional co-activator to regulate expression of several genes which are involved in tumor growth, progression and drug resistance. The carboxyl terminal 186 amino acids of EGFR has transcriptional activation activity and the AT-rich sequence (ATRS) of the target gene promoter is required for EGFR binding. In the present study, we show that AP2A1, the alpha 1 adaptin subunit of AP2 complex, interact with EGFR not only in the cytoplasm but also in the nucleus. The EGFR-AP2A1 interaction is stimulated by EGF and suppressed by Iressa, a tyrosine kinase inhibitor. Knockdown AP2A1 expression in cancer cells abrogates EGF-induced EGFR nuclear translocation. Interesting, the ATRS reporter activity is enhanced by depletion of cellular AP2A1. These results indicate that AP2A1 is required for EGFR nuclear translocation and suppresses the transcriptional activation activity of EGFR. Thus, we demonstrate here the novel role of AP2A1 in EGFR trafficking and transcriptional regulation. Citation Format: Huai-Gu Chen, Sheng-Chieh Hsu. Role of AP2A1 in EGFR nuclear translocation and transcriptional activation activity. [abstract]. In: Proceedings of the 105th Annual Meeting of the American Association for Cancer Research; 2014 Apr 5-9; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2014;74(19 Suppl):Abstract nr 3325. doi:10.1158/1538-7445.AM2014-3325
Syphilitic Primary Optic Atrophy
Authors: Sidney Levin, Laurence D. Trevett, Milton Greenblatt
Journal: New England Journal of Medicine (1947)

A FEW years ago the outlook regarding vision for patients with syphilitic primary optic atrophy was generally considered extremely poor, regardless of the type of therapy used. This attitude tends to persist in spite of the gratifying reports by Moore et al.1 and others2 , 3 of unusually successful results with malaria treatment. One of the reasons for pessimism is that there is too often an excessive delay in starting treatment and that, as a result, optic atrophy may progress to blindness before adequate treatment is instituted. This delay often appears to be due to failure to make the proper diagnosis, lack . . .
Septicemia Following Peroral Biopsy of the Small Intestine
Authors: P. Mainguet, J. Butzler, J. Sternon
Journal: Endoscopy (1974)

Two cases of a rare complication of the small bowel biopsy are presented. Septicemia to gram negative bacilli occurred within 24 hr and 48 hr after a successful jejunal biopsy. The patients recovered their prebiopsy state after 3 days of antibiotic therapy. Role of intestinal intubation for perfusion studies or motor jejunal activity registrement soon after jejunal biopsy and of bacterial overgrowth in the small bowel are discussed.
Tilting the Balance between Facilitatory and Inhibitory Functions of Mammalian and Drosophila Complexins Orchestrates Synaptic Vesicle Exocytosis
Authors: Mingshan Xue, Yong Qi Lin, Hongling Pan, Kerstin Reim, Hui Deng, Hugo J. Bellen, Christian Rosenmund
Journal: Neuron (2009)
ON THE IMMUNIZATION TREATMENT OF HAY FEVER.
Authors: E. FLETCHER INGALS
Journal: JAMA (1902)

Prompted by the favorable reports of Dr. H. Holbrook Curtis upon his so-called immunization treatment of hay fever by the<i>Ambrosia artemesiefolia</i>, my associate, Dr. John Edwin Rhodes, and myself last summer decided to give the treatment a careful trial. We tried to obtain from the leading druggists in this city reliable preparations of the drugs, but found they were not kept in stock and therefore we corresponded with some manufacturing chemists with a hope of obtaining the desired remedies, but were unsuccessful. Parke, Davis &amp; Co.
SMALL ARTERY ELASTICITY, BUT NEITHER CAROTID ARTERY ELASTICITY NOR AORTA DISTENSIBILITY, PREDICTS CARDIOVASCULAR EVENTS IN AN ASYMPTOMATIC - RESULTS OF THE MULTI-ETHNIC STUDY OF ATHEROSCLEROSIS
Authors: Daniel A. Duprez, David R. Jacobs, Pamela L. Lutsey, David A. Bluemke, David A. Bluemke, Lyndia C. Brumback, Jospeh Polak, Richard A. Kronmal
Journal: Journal of the American College of Cardiology (2010)
Mediastinoscopy in the surgical management of lung carcinoma.
Authors: F Paris, V Tarazona, E Blasco, A Canto, M Casillas, J Pastor
Journal: Thorax (1975)

Up to December 1973, we had performed 100 mediastinoscopies for lung carcinoma. Fifty-two were positive and 48 negative. In 80 cases there was clinical or radiological suspicion of mediastinal invasion. With radiological evidence of mediastinal node involvement exploration was positive in 32 out of 35 cases, when chest radiography findings were equivocal in 19 out of 45, and when radiology of the mediastinum was normal in only one of 20 cases. Mediastinoscopy was more frequently positive when the carcinoma was oat-cell or anaplastic. Of 48 patients with negative biopsies, 41 were explored. In 26 the carcinoma extended beyond the lung. In 1973 we circularized 83 thoracic surgeons concerning (1) the use of mediastinoscopy for patients with lung carcinoma assessed for surgery, (2) the significance of mediastinal node involvement, (3) the results of radiotherapy alone in patients rejected for surgery, and (4) the survival rate in patients with positive mediastinal nodes treated with surgery alone or together with radiotherapy. The replies to the questionnaire are summarized. The authors emphasize the usefulness of mediastinoscopy but state that care must be taken when deciding to withhold operation for a possible cure.
Gastric cancer in Scotland: changing epidemiology, unchanging workload.
Authors: D M Sedgwick, J A Akoh, I M Macintyre
Journal: BMJ (1991)

To determine the changes in incidence of and mortality from gastric cancer in Scotland between 1978 and 1987 and in the operative workload in Lothian between 1979 and 1988.Analysis of national incidence statistics for gastric cancer derived from the Scottish national cancer registry, deaths from gastric cancer recorded by the registrar general for Scotland, and Lothian surgical audit data.Scotland and Lothian Health Board area.Patients in Scotland with gastric cancer during 1978 to 1987 inclusive; patients in Scotland with gastric cancer recorded on their death certificate as cause of death during 1978 to 1987; patients who had an operation in Lothian for gastric cancer during 1979 to 1988.Changes in incidence of and mortality from gastric cancer in Scotland from 1978 to 1987 and in the number of operations performed for gastric cancer in Lothian from 1979 to 1988.Mortality from gastric cancer in Scotland fell by about 25% over the 10 years. The incidence and standardised incidence of gastric cancer showed a marginal decline of about 9%. The differences in trends between incidence and mortality were significant (p less than 0.05).This study shows that the surgical workload associated with gastric cancer is not declining. This is because the incidence has remained almost static, which may be due to the relative increase in the numbers of older people in the population, who are at greater risk of developing gastric cancer. Gastric cancer should not be regarded as a disease in decline. Incidence and workload should determine resources allocated to this disease rather than mortality statistics.
Delayed, Traumatic Dislocation of the Cervical Spine
Authors: Laibe A. Kessler
Journal: JAMA (1973)

Of the last 39 patients admitted for cervical fracture-dislocations, five had diagnosis delayed from two days to six months, because dislocation was not apparent in the initial x-ray films. Patients with mechanical, cord, or root injuries require special views plus a high index of suspicion and careful follow-up. Head injuries may present inescapable diagnostic and treatment traps.
Epidemiology of myelodysplastic syndromes and chronic myeloproliferative disorders in the United States, 2001-2004, using data from the NAACCR and SEER programs
Authors: Dana E. Rollison, Nadia Howlader, Martyn T. Smith, Sara S. Strom, William D. Merritt, Lynn A. Ries, Brenda K. Edwards, Alan F. List
Journal: Blood (2008)
Dissecting the complement pathway in hepatic injury and regeneration with a novel protective strategy
Authors: Keely M. Marshall, Songqing He, Zhi Zhong, Carl Atkinson, Stephen Tomlinson
Journal: The Journal of Experimental Medicine (2014)

Liver resection is commonly performed under ischemic conditions, resulting in two types of insult to the remnant liver: ischemia reperfusion injury (IRI) and loss of liver mass. Complement inhibition is recognized as a potential therapeutic modality for IRI, but early complement activation products are also essential for liver regeneration. We describe a novel site-targeted murine complement inhibitor, CR2-CD59, which specifically inhibits the terminal membrane attack complex (MAC), and we use this protein to investigate the complement-dependent balance between liver injury and regeneration in a clinical setting of pharmacological inhibition. CR2-CD59 did not impact in vivo generation of C3 and C5 activation products but was as effective as the C3 activation inhibitor CR2-Crry at ameliorating hepatic IRI, indicating that the MAC is the principle mediator of hepatic IRI. Furthermore, unlike C3 or C5 inhibition, CR2-CD59 was not only protective but significantly enhanced hepatocyte proliferation after partial hepatectomy, including when combined with ischemia and reperfusion. Remarkably, CR2-CD59 also enhanced regeneration after 90% hepatectomy and improved long-term survival from 0 to 70%. CR2-CD59 functioned by increasing hepatic TNF and IL-6 levels with associated STAT3 and Akt activation, and by preventing mitochondrial depolarization and allowing recovery of ATP stores.
Erythema nodosum associated with invasive amoebiasis and giardiasis
Authors: A.D. Harries, J. Taylor
Journal: British Journal of Dermatology (1986)

Journal Article Erythema nodosum associated with invasive amoebiasis and giardiasis Get access A.D. Harries, A.D. Harries Hospital for Tropical Diseases, 4 St Pancras Way, London, U.K. Search for other works by this author on: Oxford Academic Google Scholar J. Taylor J. Taylor Guys Hospital, London, U.K. Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 114, Issue 3, 1 March 1986, Page 394, https://doi.org/10.1111/j.1365-2133.1986.tb02836.x Published: 01 March 1986
Psychiatrische Vorlesungen für Ärzte
Authors: Kurt Schneider
Journal: JAMA (1934)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Aldehyde dehydrogenase 2 and β3-adrenergic receptor gene polymorphisms: their association with elevated liver enzymes and metabolic syndrome
Authors: Chisato Murata, Tetsu Watanabe, Hiroyuki Furuya, Yoshihiko Sugioka, Hajime Mikurube, Akira Yokoyama, Yoshihito Atsumi, Kempei Matsuoka, Isao Okazaki
Journal: Metabolism (2003)
Determination of transmural location of onset of activation from cardiac surface electrograms.
Authors: M J Burgess, R L Lux, P R Ershler, R Menlove
Journal: Circulation (1990)

Methods of estimating depth of origin of ventricular activation from cardiac surface electrograms were evaluated in experiments on eight dogs. The ventricles were paced via multielectrode needle arrays placed transmurally in from four to six locations in the wall of the left ventricle. A multiplexed data-recording system was used to simultaneously record from 64 unipolar cardiac surface electrodes during pacing at each multielectrode needle site. The four indexes evaluated were the maximum and average gradients of activation isochrones around the site of earliest epicardial activation, the QRS area at the site of earliest epicardial activation, the interval between the QRS onset computed from all 64 epicardial surface electrograms, and the time of the minimum dV/dt in the electrogram displaying the earliest epicardial activation time (t(ee)-t(rmso) interval). Correlation coefficients between depth of stimulation and average and maximum gradients of isochrones, QRS area at the site of earliest epicardial activation, and t(ee)-t(rmso) interval were 0.985 or higher. These methods, particularly those involving gradients of isochrones, should be useful for evaluating electromaps of patients undergoing surgery for ablation of tachyarrhythmias.
Angiotensin II stimulates cardiac myocyte hypertrophy via paracrine release of TGF-β1 and endothelin-1 from fibroblasts
Authors: Mary O. Gray, Carlin S. Long, Judith E. Kalinyak, Hong-Tai Li, Joel S. Karliner
Journal: Cardiovascular Research (1998)

Objective: We sought to determine whether angiotensin II (Ang II) promotes hypertrophy of cardiac myocytes directly or via paracrine mechanisms mediated by cardiac fibroblasts. Methods: We studied neonatal rat cardiac myocytes and fibroblasts in culture as a model system. Paracrine effects of Ang II were identified using conditioned medium and co-culture experiments. Results: Ang II type 1 (AT1) receptors responsible for myocyte growth localized to fibroblasts in radioligand binding, emulsion autoradiography, Western analysis, and immunofluorescence staining experiments. The bulk of AT1 receptor binding in myocyte cultures (1343±472 sites/cell) was to Ang II receptors on contaminating fibroblasts (9747±2126 sites/cell). Ang II induced significant paracrine trophic effects on myocytes in conditioned medium (40% increase in protein synthesis over control) and co-culture (4-fold increase over control) experiments. TGF-β1 and endothelin-1 were paracrine mediators of hypertrophy in neutralization experiments. Conclusions: Ang II stimulates cardiac myocyte hypertrophy via paracrine release of TGF-β1 and endothelin-1 from cardiac fibroblasts in a neonatal rat cell culture model.
The Immunopathogenesis of Glomerulonephritis Associated with Mixed Cryoglobulinemia
Authors: Charles N. Gamble, Stanley W. Ruggles
Journal: New England Journal of Medicine (1978)

“Essential” mixed cryoglobulinemia is characterized by dependent purpura, arthralgia and weakness and is frequently associated with glomerulonephritis.1 2 3 4 5 6 7 “Essential” or Type II2 cryoglobulins are a mixture of monoclonal immunoglobulin (Ig) and polyclonal IgG, with the former possessing antibody activity against the latter.1 2 3 Most Type II cryoglobulins are composed of IgM-IgG,1 2 3 but IgG-IgG2 and IgA-IgG2,8 9 10 cryoglobulins have also been reported. The glomerulonephritis of mixed cryoglobulinemia is thought to be due to the deposition of immune complexes composed of IgM (or other monoclonal Ig’s), which represents antibody, and IgG, which represents antigen, but this hypothesis has not been thoroughly documented.2,4 It is also . . .
Report on a single-topic conference on “Chronic Viral Hepatitis-Strategies to Improve Effectiveness of Screening and Treatment”
Authors: John W. Ward, Anna S.F. Lok, David L. Thomas, Hashem B. El–Serag, Ray W. Kim
Journal: Hepatology (2011)

The 2010 Institute of Medicine report on "Hepatitis and Liver Cancer" indicated that lack of knowledge and awareness about chronic hepatitis B (HBV) and C virus (HCV) infections and insufficient understanding about the extent and seriousness of this public health problem impeded current efforts to prevent and control hepatitis B and C. A single-topic conference was held in June 2011 to discuss strategies to improve the effectiveness of screening, care referral, and clinical management of chronic HBV and HCV infections with the ultimate goal of reducing morbidity and mortality from these infections. Various models that have been shown to improve hepatitis screening and effectiveness of hepatitis treatment in the community, including rural settings and populations that have traditionally been excluded due to comorbidities, were presented. Recent advances in laboratory testing, medical management, and new antiviral therapies will not decrease the burden of viral hepatitis if persons at risk for or who are living with viral hepatitis are not aware of the risks, have not been diagnosed, or have no access to care. Systematic changes in our health care delivery system and enhanced coordination of prevention and care services with partnerships between public health leaders and clinicians through education of the public and health care providers and linkage of infected persons with care and treatment services can increase the success of preventing viral hepatitis and the effectiveness of hepatitis treatment in the real world. Implementation of these changes is feasible and will require policy changes, coordination among government agencies, and collaboration between government agencies, health care providers, community organizations, and advocacy groups.
Endothelial cell activation during edematous attacks of hereditary angioedema types I and II
Authors: Erika Kajdácsi, Péter K. Jani, Dorottya Csuka, Lilian Ágnes Varga, Zoltán Prohászka, Henriette Farkas, László Cervenak
Journal: Journal of Allergy and Clinical Immunology (2014)
Acute non-specific inflammation and modification of macrophage and lymphocyte funtions
Authors: J.P. GIROUD, YAO CHIN SHENG, M. PELLETIER, I. FLORENTIN, J. BIRD
Journal: British Journal of Dermatology (2006)

The acute inflammatory response is a common phenomenon experienced by the physician in a wide variety of clinical situations. One of the major problems facing the investigator in this field of research who wishes to look at the cellular and humoral responses involved, is that in most of the animal models previously used, the inflammatory reaction has been provoked in subcutaneous tissues. Thus, a quantitative assessment of leucocyte emigration and mediator production in the inflamed area is technically difficult without resorting to complicated and artificial methods. Inflammation provoked in the pleural cavity provides a useful tool in the study of these problems since the collection of cells and analysis of humoral factors in exudates is easily accomplished. Among the irritants that may be used, we focused our interest on calcium pyrophosphate (CaPP) crystals, a non-diffusible, non-antigenic and endotoxin-free irritant, because their deposition is implicated in pseudogout and chondrocalcinosis in man (MacCarty, 1973). Calcium pyrophosphate-induced pleurisy is typified by an acute reaction, dominated by polymorphonuclear leucocytes, reaching its maximal intensity at about 5 h and disappearing within 48 h (Willoughby et al., 1975). It was found to be independent of the complement system. Examination of the known mediators of inflammation revealed no significant participation of either histamine or 5-hydroxytryptamine. There was an early rise in PGE2 followed by a greater rise in PGF2 alpha as the reaction diminished (Capasso et al., 1975). More recently, we have demonstrated the presence of a small quantity of thromboxane and a large quantity of prostacyclin during the first 2 hours of this inflammatory process. It was also shown that this type of acute inflammation was accompanied by the very rapid liberation of acute phase proteins both locally, in the exudate, and systemically in the serum (Tissot et al., 1983). Some of these events were also examined during the pleural reaction to other types of irritants (Capasso et al., 1975) and gave similar results (Tissot et al., 1983).