tbuckley/cabot-search huggingface dataset:
High-Dose Atorvastatin after Stroke or Transient Ischemic Attack
Authors: Pierre Amarenco, Julien Bogousslavsky, Alfred Callahan, Larry B Goldstein, Michael Hennerici, Amy E Rudolph, Henrik Sillesen, Lisa Simunovic, Michael Szarek, K M A Welch, Justin A Zivin
Journal: New England Journal of Medicine (2006)

Statins reduce the incidence of strokes among patients at increased risk for cardiovascular disease; whether they reduce the risk of stroke after a recent stroke or transient ischemic attack (TIA) remains to be established.We randomly assigned 4731 patients who had had a stroke or TIA within one to six months before study entry, had low-density lipoprotein (LDL) cholesterol levels of 100 to 190 mg per deciliter (2.6 to 4.9 mmol per liter), and had no known coronary heart disease to double-blind treatment with 80 mg of atorvastatin per day or placebo. The primary end point was a first nonfatal or fatal stroke.The mean LDL cholesterol level during the trial was 73 mg per deciliter (1.9 mmol per liter) among patients receiving atorvastatin and 129 mg per deciliter (3.3 mmol per liter) among patients receiving placebo. During a median follow-up of 4.9 years, 265 patients (11.2 percent) receiving atorvastatin and 311 patients (13.1 percent) receiving placebo had a fatal or nonfatal stroke (5-year absolute reduction in risk, 2.2 percent; adjusted hazard ratio, 0.84; 95 percent confidence interval, 0.71 to 0.99; P=0.03; unadjusted P=0.05). The atorvastatin group had 218 ischemic strokes and 55 hemorrhagic strokes, whereas the placebo group had 274 ischemic strokes and 33 hemorrhagic strokes. The five-year absolute reduction in the risk of major cardiovascular events was 3.5 percent (hazard ratio, 0.80; 95 percent confidence interval, 0.69 to 0.92; P=0.002). The overall mortality rate was similar, with 216 deaths in the atorvastatin group and 211 deaths in the placebo group (P=0.98), as were the rates of serious adverse events. Elevated liver enzyme values were more common in patients taking atorvastatin.In patients with recent stroke or TIA and without known coronary heart disease, 80 mg of atorvastatin per day reduced the overall incidence of strokes and of cardiovascular events, despite a small increase in the incidence of hemorrhagic stroke. (ClinicalTrials.gov number, NCT00147602 [ClinicalTrials.gov].).
Regulation of Bcl-2 family proteins in antibody-dependent cellular cytotoxicity (ADCC) of small cell lung cancer cells mediated by a bispecific molecule OKT3xbombesin antagonist
Authors: Jiehua Zhou, Ruikun Zhong, Edward D. Ball
Journal: Cancer Research (2005)

Proc Amer Assoc Cancer Res, Volume 46, 2005

2262 

Bcl-2 family proteins play a critical role in the regulation of apoptosis. The anti-apoptotic protein Bcl-2 is expressed in 75% of SCLC. We have shown that a bispecific molecule (BsMol) containing OKT3 (anti-CD3 antibody) conjugated with a bombesin antagonist was able to activate T lymphocytes and mediate SCLC cell apoptosis at a low effector to target (E:T) cell ratio. Since most SCLC cell lines do not express caspase 8, an initiator caspase in the death-receptor pathway, we studied whether Bcl-2 family proteins contributed in the process of tumor cell apoptosis by ADCC. Four SCLC cell lines H345, H69, SHP77 and DMS273 were studied. T lymphocytes were separated from healthy donors. SCLC cells were mixed with T lymphocytes at 1:1 ratio in the presence of the BsMol or mouse IgG2a as a negative control. The mixed cells were stained with annexin V, CD45 and propidium iodide (PI), analyzed by flow cytometry from 4h to 72h. Whole cell lysates were prepared at 24, 48, and 72h, and analyzed for expression of Bcl-2, Bad and phosphorylated Bad (Ser112), Bax, Bak, and cleaved poly(ADP-ribose) polymerase (PARP) by Western blot. H345 cells are exquisitely sensitive to ADCC. There is high expression of Bcl-2, Bad and phosphorylated Bad at baseline. Western blot analysis showed phosphorylated Bad decreased significantly at 24h, and became undetectable at 72h in the presence of BsMol, while the expression of Bad remained stable. There was decreased expression of Bcl-2, and increased expression of Bak, Bax, and cleaved PARP at 72h. Flow cytometry analysis showed an increase of annexin V positive SCLC cells from 15% at 24h to 40% at 72h in the presence of the BsMol. Similar results were observed in SCLC cell lines H69 and SHP77. In contrast, DMS 273 cells, which are insensitive to ADCC at low E:T ratio, have barely detectable expression of Bcl-2 at baseline. After 48h, Bcl-2 became easily detectable, then increased significantly at 72h. The expression of cleaved PARP decreased at 72h. While the percentage of annexin V positive cells remained stable from 24h to 72h, the percentage of SCLC cells increased from 26% to 60% at 72h. We conclude that there is a dynamic change in expression of Bcl-2 family proteins in the process of ADCC mediated by the BsMol, leading to apoptosis and SCLC cell death. The increased expression of Bcl-2 in DMS 273 cells during the process may be the underlying mechanism of its resistance of ADCC. Blocking the upregulation of Bcl-2 in combination with immunotherapy may enhance the cytotoxicity of resistant SCLC cells.
Molecular Mechanism of a Mild Phenotype in Coagulation Factor XIII (FXIII) Deficiency: A Splicing Mutation Permitting Partial Correct Splicing of FXIII A-Subunit mRNA
Authors: Hanna Mikkola, Laszlo Muszbek, Elina Laiho, Martti Syrjälä, Eija Hämäläinen, Gizela Haramura, Toivo Salmi, Leena Peltonen, Aarno Palotie
Journal: Blood (1997)
Tuberculosis: Bacteriology, Pathology and Laboratory Diagnosis with Sections on Immunology, Epidemiology, Prophylaxis and Experimental Therapy.
Authors: Edward R. Baldwin, S.A. Petroff, Leroy S. Gardner
Journal: JAMA (1927)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Proposed Change of Patent Rules
Authors: Mark B. McClellan
Journal: JAMA (2002)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Circulating Endothelial Microparticles in Malawian Children With Severe Falciparum Malaria Complicated With ComaRESEARCH LETTERS
Authors: Valéry Combes, Terrie E. Taylor, Irène Juhan-Vague, Jean Louis Mège, James Mwenechanya, Madalitso Tembo, Georges E. Grau, Malcolm E. Molyneux
Journal: JAMA (2004)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Community-Based Interventions to Promote Blood Pressure Control in a Developing Country
Authors: Tazeen H. Jafar, Juanita Hatcher, Neil Poulter, Muhammad Islam, Shiraz Hashmi, Zeeshan Qadri, Rasool Bux, Ayesha Khan, Fahim H. Jafary, Aamir Hameed, Ata Khan, Salma H. Badruddin, Nish Chaturvedi
Journal: Annals of Internal Medicine (2009)

Jafar and colleagues assessed the effectiveness of community-based interventions on blood pressure in 1341 hypertensive adults in Karachi, Pakistan. Participants received home health education (HHE...
Direct visualization of dispersed 11q13 chromosomal translocations in mantle cell lymphoma by multicolor DNA fiber fluorescence in situ hybridization
Authors: JW Vaandrager, E Schuuring, E Zwikstra, CJ de Boer, KK Kleiverda, JH van Krieken, HC Kluin-Nelemans, GJ van Ommen, AK Raap, PM Kluin
Journal: Blood (1996)
The Effects of Salsalate on Glycemic Control in Patients With Type 2 Diabetes
Authors: Allison B. Goldfine, Vivian Fonseca, Kathleen A. Jablonski, Laura Pyle, Myrlene A. Staten, Steven E. Shoelson
Journal: Annals of Internal Medicine (2010)

Small studies have shown that salsalate reduces blood glucose concentration. Goldfine and associates randomly assigned patients with type 2 diabetes to 1 of 3 doses of salsalate or placebo. Salsala...
Definitions of Medical Injuries—Reply
Authors: Chunliu Zhan, Marlene R. Miller
Journal: JAMA (2004)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
1046. Insertional Leukemogenesis after Retroviral Gene Transfer into Murine Hematopoietic Stem Cells
Authors: Martijn H. Brugman, Monique M. A. Verstegen, Trudi P. Visser, Erna Fränzel-Luiten, Manfred Schmidt, Albertus W. Wognum, Christof vonKalle, Gerard Wagemaker
Journal: Molecular Therapy (2004)

Replication defective retroviruses deliver transgenes into hematopoietic stem cells (HSC) with high efficacy. The first successful clinical study revealed an unexpectedly high frequency of insertional leukemogenesis, not predicted by extensive preclinical experimental studies. In cell lines, the frequency of insertional oncogenic events has been estimated at approximately 10-7 per transduced cell. To examine the in vivo incidence, we monitored mice transplanted with transduced stem cells for observation times up to 342 days after transplantation and retransplanted the cells into secondary recipients at selected time intervals. The observations were made in the context of ectopic expression of wtSTAT5 to study its effect on stem cell repopulating capacity.
Probiotics for preventing eczema
Authors: R.J. Boyle
Journal: British Journal of Dermatology (2010)

Journal Article Probiotics for preventing eczema Get access R.J. Boyle R.J. Boyle Department of Paediatrics, Imperial College London, London W2 1PG, U.K. E‐mail: r.boyle@imperial.ac.uk Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 163, Issue 3, 1 September 2010, Page 450, https://doi.org/10.1111/j.1365-2133.2010.09934.x Published: 01 September 2010
Mesenchymal stem cell therapy ameliorates diabetic hepatocyte damage in mice by inhibiting infiltration of bone marrow-derived cells
Authors: Kanna Nagaishi, Koji Ataka, Eijiro Echizen, Yoshiaki Arimura, Mineko Fujimiya
Journal: Hepatology (2013)

Although mesenchymal stem cells (MSCs) have been implicated in hepatic injury, the mechanism through which they contribute to diabetic liver disease has not been clarified. In this study, we investigated the effects of MSC therapy on diabetic liver damage with a focus on the role of bone-marrow–derived cells (BMDCs), which infiltrate the liver, and elucidated the mechanism mediating this process. Rat bone-marrow (BM)-derived MSCs were administered to high-fat diet (HFD)-induced type 2 diabetic mice and streptozotocin (STZ)-induced insulin-deficient diabetic mice. MSC-conditioned medium (MSC-CM) was also administered to examine the trophic effects of MSCs on liver damage. Therapeutic effects of MSCs were analyzed by assessing serum liver enzyme levels and histological findings. Kinetic and molecular profiles of BMDCs in the liver were evaluated using BM-chimeric mice. Curative effects of MSC and MSC-CM therapies were similar because both ameliorated the aggravation of aspartate aminotransferase and alanine aminotransferase at 8 weeks of treatment, despite persistent hyperlipidemia and hyperinsulinemia in HFD-diabetic mice and persistent hyperglycemia in STZ-diabetic mice. Furthermore, both therapies suppressed the abnormal infiltration of BMDCs into the liver, reversed excessive expression of proinflammatory cytokines in parenchymal cells, and regulated proliferation and survival signaling in the liver in both HFD- and STZ-diabetic mice. In addition to inducing hepatocyte regeneration in STZ-diabetic mice, both therapies also prevented excessive lipid accumulation and apoptosis of hepatocytes and reversed insulin resistance (IR) in HFD-diabetic mice. Conclusion : MSC therapy is a powerful tool for repairing diabetic hepatocyte damage by inhibiting inflammatory reactions induced by BMDCs and IR. These effects are likely the result of humoral factors derived from MSCs. (Hepatology 2014;59:1816–1829)
Abstract 9907: A Single Infusion of MDCO-216 (ApoA-1 Milano/POPC) Induces Marked Changes on the Lipid Profile
Authors: David G Kallend, Alain Bobillier, S. Eralp Belibas, Herman Kempen, Jakobus Burggraaf, Joannes Reijers, Matthijs Moerland, Peter L Wijngaard
Journal: Circulation (2014)

Introduction: Human carriers of the apolipoprotein A-1 Milano variant have a reduced incidence of cardiovascular disease. Regression of atherosclerosis was observed in a prior Phase II intra-vascul...
A multicentre cohort study of acute heart failure syndromes in Korea: rationale, design, and interim observations of the Korean Acute Heart Failure (<scp>KorAHF</scp>) registry
Authors: Sang Eun Lee, Hyun‐Jai Cho, Hae‐Young Lee, Han‐Mo Yang, Jin‐Oh Choi, Eun‐Seok Jeon, Min‐Seok Kim, Jae‐Joong Kim, Kyung‐Kuk Hwang, Shung Chull Chae, Suk Min Seo, Sang Hong Baek, Seok‐Min Kang, Il‐Young Oh, Dong‐Ju Choi, Byung‐Su Yoo, Youngkeun Ahn, Hyun‐Young Park, Myeong‐Chan Cho, Byung‐Hee Oh
Journal: European Journal of Heart Failure (2014)
A dilemma: A half mixed compound?
Authors: D. Dean
Journal: BMJ (1999)

Some lessons learnt during high school chemistry remain with me, none more so than the distinction between a mixture and a compound:

Mixture: a substance consisting of two or more substances mixed together without any chemical bonding between them.

Compound: a substance that contains atoms of two or more chemical elements held together by chemical bonds.

As a teenager I did not object to being termed “half caste.” For the past few years I have preferred, and asked others to use, …
Abstract A50: Crotamine derived fusion short-peptides and their effect on melanoma and breast cancer cells cultured in vitro
Authors: Nicole Caroline Mambelli, Paulo Luis De-Sá-Júnior, Adilson Kleber Ferreira, Ricardo Alexandre Azevedo, Diana Aparecida Câmara, Irina Kerkis
Journal: Clinical Cancer Research (2015)

Abstract The search for molecules with therapeutic potential against cancer is a crucial issue to reduce the amount of death in human population around the world. Previously, we showed that crotamine, a natural polypeptide from the venom of the rattlesnake Crotalus durissus terrificus, has ability to induce cancer cells apoptosis in vitro, as well as, delay and inhibit melanomas formation in vivo in mice. In order to reduce crotamine length and toxicity, while maintaining its anti-cancer properties, two short peptides were designed and synthetized. Such short peptides represent an intermediate potential step toward to the development of drugs targeted cancer death. The aim of present study was to analyze pro-apoptotic activity of both of these peptides (1 and 2), composed by crotamine (crot.) and BAX (pro-apoptotic protein from BCL2 family) both derived sequences in melanoma and breast cancer cells in vitro. Melanoma and breast cancer cells (MEL-85, A2058, B16-F10 and SKBR3) were used. The MTT assay was performed after addition of both of these peptides used in different concentrations into cancer cells. The expression of proteins (PARP, Cleaved - Caspase 3, Caspase 3, Phospho - BAD) was evaluated by western blotting. Flow cytometry was performed to evaluate the cell cycle. The mitochondria potential was also verified before and after peptides addition. Morphologic changes, such as, detachment from substrate, cell contraction, loss of inter-cell elongations and several others effects were observed in cancer cells after 24 hours of incubation with peptides. At that time, the peptides exhibit cytotoxic activity as verified by MTT assay. Cell cycle analyses demonstrated that they decrease the timing of G2/M phases, while increasing a sub-G0/G1 phase. Unexpectedly, both peptides increase mitochondria potential of cancer cells, when compared with control cultures (without addition of peptides). Increase of expression pro-apoptotic proteins, such as, cleaved Caspase 3 and PARP was evidenced in cancer cells after addition of peptide -1, while Phospho-BAD was increased after addition of peptide - 2. Our data suggest that both peptides are efficient to trigger cell death in melanoma and breast cancer cells in vitro. Crot alone was not able to induce such changes in cancer cells. Citation Format: Nicole Caroline Mambelli, Paulo Luis De-Sá-Júnior, Jr., Adilson Kleber Ferreira, Ricardo Alexandre Azevedo, Diana Aparecida Câmara, Irina Kerkis, Sr.. Crotamine derived fusion short-peptides and their effect on melanoma and breast cancer cells cultured in vitro. [abstract]. In: Proceedings of the AACR Precision Medicine Series: Drug Sensitivity and Resistance: Improving Cancer Therapy; Jun 18-21, 2014; Orlando, FL. Philadelphia (PA): AACR; Clin Cancer Res 2015;21(4 Suppl): Abstract nr A50.
Ramelteon for Delirium in Hospitalized Patients
Authors: Kotaro Hatta, Yasuhiro Kishi, Ken Wada
Journal: JAMA (2015)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal