METHYLTESTOSTERONE THERAPY FOR HEREDITARY EPISODIC EDEMA (HEREDITARY ANGIONEUROTIC EDEMA)
Authors: W. B. Spaulding
Journal: Annals of Internal Medicine (1960)

Article1 October 1960METHYLTESTOSTERONE THERAPY FOR HEREDITARY EPISODIC EDEMA (HEREDITARY ANGIONEUROTIC EDEMA)W. B. SPAULDING, M.D., F.R.C.P. (C)W. B. SPAULDING, M.D., F.R.C.P. (C)Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-53-4-739 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptHereditary episodic edema is a rare disease, manifested by recurring attacks of spreading edema which appear rapidly, last only a few days, and leave the patient healthy between episodes. The hereditary pattern is that of a dominant genetic abnormality. The edema may involve the skin or the wall of the mouth, pharynx, larynx or gastrointestinal tract. Edema of the larynx constitutes a grave emergency which may cause death. The clinical features in two families studied personally and in others reported in the literature have previously been reviewed in detail.1Although knowledge of the clinical manifestations, heredity and prognosis is adequate,...Bibliography1. Spaulding WB: Hereditary angioneurotic oedema in two families, Canad. M. A. J. 73: 181, 1955. MedlineGoogle Scholar2. HamiltonMontagna JBW: The sebaceous glands of the hamster. I. Morphological effects of androgens on integumentary structures, Am. J. Anat. 86: 191, 1950. CrossrefMedlineGoogle Scholar3. DorfmanShipley RIRA: Androgens. Biochemistry, physiology and clinical significance, 1956, John Wiley & Sons, Inc., New York, p. 384. Google Scholar4. WernerHangerKritzler SCFMRA: Jaundice during methyltestosterone therapy, Am. J. Med. 8: 325, 1950. CrossrefMedlineGoogle Scholar5. Koszalka MF: Medical obstructive jaundice. Report of a death due to methyltestosterone, Journal-Lancet 77: 51, 1957. MedlineGoogle Scholar6. Heckel NJ: The influence of testosterone-propionate upon benign prostatic hypertrophy and spermatogenesis: a clinical and pathological study in the human, J. Urol. 43: 286, 1940. CrossrefGoogle Scholar7. McCullaghRossmiller EPHR: Methyltestosterone. 1. Androgenic effects and the production of gynecomastia and oligospermia, J. Clin. Endocrinol. 1: 496, 1941. CrossrefGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Toronto,*Received for publication March 16, 1960.From the Department of Medicine, University of Toronto, and the Medical Service, Toronto General Hospital.Requests for reprints should be addressed to W. B. Spaulding, M.D., Toronto General Hospital, Toronto,Canada. 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