tbuckley/cabot-search huggingface dataset:
Comet tail artifact: A transthoracic chest ultrasound sign useful in assessment of interstitial lung diseases
Authors: Ali Hasan, Hoda Makhlouf
Journal: European Respiratory Journal (2013)

Objective:   This prospective study was conducted to evaluate the value of comet tail artifacts (long, vertical, well-defined, hyperechoic, dynamic lines, originating from the pleural line) in assessment of interstitial lung diseases (ILD) and compare them with the findings of chest high resolution computed tomography (HRCT) and pulmonary function tests (PFT).    Methods:   Sixty-one patients with ILD underwent transthoracic ultrasound for assessment of the presence of comet tail artifacts and the distance between them. These findings were compared with that of chest HRCT (ground glass, reticular, nodular or honey combing) and PFT as forced vital capacity (FVC), total lung capacity (TLC), diffusion capacity for carbon monoxide (DLCO) and partial arterial oxygen pressure (PaO 2 ).   Results:   All patients had diffuse anterolateral comet tail artifacts (B lines). The distance between each two adjacent B lines correlated with the severity of the disease on chest HRCT where B3 (the distance was 3 mm) correlated with ground glass appearance and B7 (the distance was 7 mm) correlated with extensive fibrosis and honey combing. The distance between comet tail artifacts also inversely correlated with FVC  (r=- 0.452, p   0.001) , TLC  (r= -0.276, p=0.03) , DLCO  (r=- 0.445, p   0.001)  and PaO 2  ( r= -0.241,P    Conclusions:   Comet tail artifact, a lung ultrasound sign seems to be useful in assessment of ILD.
Further Studies of the Mammary Tumor Agent of Strain RIII Mice
Authors: Howard B. Andervont, Thelma B. Dunn
Journal: JNCI Journal of the National Cancer Institute (1965)

Journal Article Further Studies of the Mammary Tumor Agent of Strain RIII Mice Get access Howard B. Andervont, Howard B. Andervont Laboratory of Biology and Laboratory of Pathology, National Cancer Institute,2Bethesda, Maryland Search for other works by this author on: Oxford Academic PubMed Google Scholar Thelma B. Dunn Thelma B. Dunn Laboratory of Biology and Laboratory of Pathology, National Cancer Institute,2Bethesda, Maryland Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 35, Issue 1, July 1965, Pages 39–54, https://doi.org/10.1093/jnci/35.1.39 Published: 01 July 1965 Article history Received: 21 October 1964 Published: 01 July 1965
Information on community health services
Authors: S. Godden
Journal: BMJ (2000)

The current thrust of government policy in the United Kingdom is to shift acute care to alternative settings. The critical question is whether these arrangements will meet the health and social care needs of the local community, and that question can be answered only if there are data on needs, service use, and outcomes. The fragmented arrangements for providing and funding health and social care present a compelling case for universal standardised data collection. Yet the NHS information strategy, far from strengthening community information, suggests its contraction

Data sets and data collection for community NHS services have a chequered history in the NHS. In 1981 Dame Edith Korner's steering group on health services information recommended standardised datasets for community health services and acute hospital services. As a result, three types of community data are collected: on staff groups, on facilities including beds, and on patient contacts.1 Despite limitations, the data have proved essential for …
Growth rate of early-stage hepatocellular carcinoma in patients with chronic liver disease
Authors: Chansik An, Youn Ah Choi, Dongil Choi, Yong Han Paik, Sang Hoon Ahn, Myeong-Jin Kim, Seung Woon Paik, Kwang-Hyub Han, Mi-Suk Park
Journal: Clinical and Molecular Hepatology (2015)

Background/Aims The goal of this study was to estimate the growth rate of hepatocellular carcinoma (HCC) and identify the host factors that significantly affect this rate. Methods Patients with early-stage HCC (n=175) who underwent two or more serial dynamic imaging studies without any anticancer treatment at two tertiary care hospitals in Korea were identified. For each patient, the tumor volume doubling time (TVDT) of HCC was calculated by comparing tumor volumes between serial imaging studies. Clinical and laboratory data were obtained from the medical records of the patients. Results The median TVDT was 85.7 days, with a range of 11 to 851.2 days. Multiple linear regression revealed that the initial tumor diameter (a tumor factor) and the etiology of chronic liver disease (a host factor) were significantly associated with the TVDT. The TVDT was shorter when the initial tumor diameter was smaller, and was shorter in HCC related to hepatitis B virus (HBV) infection than in HCC related to hepatitis C virus (HCV) infection (median, 76.8 days vs. 137.2 days; P=0.0234). Conclusions The etiology of chronic liver disease is a host factor that may significantly affect the growth rate of early-stage HCC, since HBV-associated HCC grows faster than HCV-associated HCC. Keywords: Hepatocellular carcinoma; Tumor burden; Follow-up studies; Liver neoplasm; Surveillance
Depression and anxiety scales: Are they important scales in assessment of obstructive sleep apnea syndrome?
Authors: Amany Omar, Suzan Salama, Hoda A. Makhlouf, Shereen Farghaly
Journal: European Respiratory Journal (2013)

Background : Obstructive sleep apnea syndrome (OSAS) is a common sleep disorder that may result in psychological problems.  Objective : To evaluate the correlation between depression and anxiety symptoms with polysomnographic parameters in OSAS patients.  Patients and Methods : One hundred consecutive patients were prospectively enrolled in this cross sectional analytic study. All patients underwent history, Epworth sleepiness scale (ESS), Hamilton anxiety score (HAM), Beck depression inventory II score (BDI-II), anthropometric measurements and full night attended polysomnography.  Results : Thirty two percent of patients had mild OSAS, 34% had moderate OSAS and 34% had severe OSAS. Fifty five percent of patients had depression. While, only 21% had anxiety symptoms. Severe OSAS had the highest score of both HAM and BDI-II. Also, severe OSAS showed more frequent depression (73% vs. 43.8% and 47.1%) (P 0.05). There was also no significant difference between gender and both HAM or BDI-II scale.  Conclusion : Patients with severe OSAS are more frequently presented with depression as assessed by BDI-II scale. However, severity of OSAS is not associated with anxiety.
Abstract 11021: Lack of Implementation of ESC/ACC Definition of Myocardial Infarction in Contemporary Randomized Clinical Trials
Authors: Sergio Leonardi, L. Kristin Newby, E. Magnus Ohman, Paul W Armstrong
Journal: Circulation (2010)

Introduction: Although myocardial infarction (MI) is a key metric in randomized clinical trials (RCTs) evaluating new therapies, heterogeneity in MI definition may affect comparisons across RCTs as well as meta-analyses. Hence we explored the extent to which the ESC/ACC consensus recommendations for MI definition are applied in contemporary, large RCTs Methods: We performed a systematic review of RCTs with >500 patients that listed MI as part of the primary endpoint by searching ClinicalTrials.gov & MEDLINE for RCTs meeting these criteria that were initiated after the 2000 ESC/ACC MI redefinition publication. Search terms included: acute coronary syndrome, MI, percutaneous coronary intervention, coronary artery bypass grafting, coronary artery disease. We explored 3 key recommendations: 1) Use of troponin (Tn) to define endpoint MI, 2) separate reporting of spontaneous and procedural MI, and 3) infarct size reporting. Results: Of 971 studies, 114 (12%) met inclusion criteria. Of these 35 (31%) RCTs had pr...
Early restaging gallium scans predict outcome in poor-prognosis patients with aggressive non-Hodgkin's lymphoma treated with high-dose CHOP chemotherapy.
Authors: M Janicek, W Kaplan, D Neuberg, G P Canellos, L N Shulman, M A Shipp
Journal: Journal of Clinical Oncology (1997)

PURPOSE This prospective study assessed the predictive value of early restaging gallium (Ga) and computed tomographic (CT) scans in poor-prognosis patients with aggressive non-Hodgkin's lymphoma (NHL) who were treated with high-dose cyclophosphamide, doxorubicin, vincristine, and prednisone (CHOP) chemotherapy. PATIENTS AND METHODS Thirty newly diagnosed patients with bulky (&gt; or = 10 cm) advanced-stage aggressive NHL were treated with a four-cycle high-dose CHOP regimen (22 patients at maximum-tolerated dose [MTD]: cyclophosphamide 4 g/m2, doxorubicin 70 mg/m2, vincristine 2 mg, and prednisone 100 mg orally for 5 days). All patients had chest/abdominal/pelvic CT scans and 10-mCi Ga scans at baseline and following two and four cycles of therapy. Scans were reviewed in a blinded manner for CT-documented rates of response and sizes of residual masses and Ga avidity of residual masses. The results of early (post-cycle 2) and final (post-cycle 4) restaging were subsequently associated with clinical outcome. RESULTS CT-documented rates of response and residual mass sizes were indistinguishable in complete responders who remained continuously disease-free (CR-Cont), complete responders who subsequently relapsed (CR-Rel), and partial responders who then progressed (PR/Prog). In marked contrast, early restaging (post-cycle 2) Ga scans accurately delineated these three categories of patients: CR-Cont 90% Ga-negative (18 of 20 patients) versus CR-Rel 25% Ga-negative (one of four patients) versus PR/Prog 0% Ga-negative (zero of six patients) (P = .000014). At a median follow-up duration of 31 months (range, 21 to 46), 94% of patients who had negative early restaging Ga scans remain free from progression (FFP), whereas only 18% of patients who had positive early restaging Ga scans remain FFP (P = .000007). Early restaging Ga scans were more predictive for FFP than final restaging Ga scans because patients who required four full cycles of therapy to become Ga-negative were more likely to develop recurrent disease. CONCLUSION Early restaging Ga scans delineate patients who are likely to have prolonged disease-free survival from those who fail to respond to intensive induction therapy. Patients whose tumors remain Ga-positive midway through high-dose CHOP therapy have a poor outcome and may be candidates for alternative treatment.
Distal pancreatectomy with splenic preservation: A short-term outcome analysis of the Warshaw technique
Authors: Carlo Boselli, Francesco Barberini, Chiara Listorti, Elisa Castellani, Claudio Renzi, Alessia Corsi, Veronica Grassi, Alban Cacurri, Jacopo Desiderio, Stefano Trastulli, Alberto Santoro, Daniele Pironi, Federica Burattini, Roberto Cirocchi, Nicola Avenia, Giuseppe Noya, Amilcare Parisi
Journal: International Journal of Surgery (2015)
Is the prevalence of psoriasis increasing? A 30-year follow-up of a population-based cohort
Authors: K. Danielsen, A.O. Olsen, T. Wilsgaard, A.-S. Furberg
Journal: British Journal of Dermatology (2013)

Journal Article Is the prevalence of psoriasis increasing? A 30‐year follow‐up of a population‐based cohort Get access K. Danielsen, K. Danielsen Department of Dermatology, Neurology and Orthopaedic Clinic, University Hospital of North Norway, Tromsø, NorwayDepartment of Community Medicine, Faculty of Health Sciences, University of Tromsø, Tromsø, Norway Kjersti Danielsen. E‐mail: kjersti.danielsen@unn.no Search for other works by this author on: Oxford Academic Google Scholar A.O. Olsen, A.O. Olsen Department of Rheumatology, Dermatology and Infectious Diseases, The Olafia Clinic, Oslo University Hospital, Oslo, NorwayInstitute of Clinical Medicine, Faculty of Medicine, University of Oslo, Oslo, Norway Search for other works by this author on: Oxford Academic Google Scholar T. Wilsgaard, T. Wilsgaard Department of Community Medicine, Faculty of Health Sciences, University of Tromsø, Tromsø, Norway Search for other works by this author on: Oxford Academic Google Scholar A.‐S. Furberg A.‐S. Furberg Department of Community Medicine, Faculty of Health Sciences, University of Tromsø, Tromsø, NorwayDepartment of Microbiology and Infection Control, General Medical Clinic, University Hospital of North Norway, Tromsø, Norway Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 168, Issue 6, 1 June 2013, Pages 1303–1310, https://doi.org/10.1111/bjd.12230 Published: 01 June 2013 Article history Accepted: 05 January 2013 Published: 01 June 2013
Incidental findings on PET-CT scans; how they are managed and how they impact on the lung cancer pathway
Authors: Gwenllian Edwards, Ali Thahseen, Ian Williamson, Samantha Williams, Helen Howison, Alina Ionescu
Journal: European Respiratory Journal (2014)

Introduction   PET-CT is now a widely used imaging modality. By virtue of its ability to combine functional metabolic information with accurate localisation of lesions it is not surprising that PET-CTs also identify clinically silent pathology.   Aim   To determine the frequency of incidental findings on PET-CTs in a given time period, how these findings were managed and whether they impacted on the lung cancer pathway.   Methods   Data was collected retrospectively on lung cancer patients during a 12 month period and those who underwent a PET-CT in this period were included. Incidental findings on PET-CT were recorded and the patients9 records were reviewed for evidence of further discussion, investigation or follow-up of these findings.   Results   248 patients were diagnosed with lung cancer. There were 29 incidental findings amongst 70 patients who had a PET-CT. Only 1 finding was proven to be malignant. 11 were proven or presumed benign. 13 findings were noted verbally in the lung cancer MDT but not considered significant for further investigation or follow up. Such incidental findings were not documented in the lung cancer databases or in further clinic letters. None of these findings changed the management of the lung cancer itself.   Conclusion   Incidental findings on PET-CTs are not uncommon and most frequently benign. We found no evidence that these impact on our lung cancer pathway, however in a large proportion of cases there was no documentation of such findings since the agreement was that they were benign. These is scope to consider an agreed pathway for documentation of such findings in electronic patient files.
AN EXPERIMENTAL STUDY OF DIATHERMY
Authors: Ronald V. Christie, Wilhelm Ehrich, Carl A. L. Binger
Journal: The Journal of Experimental Medicine (1928)

1. An experimental pneumonia with more or less lobar distribution has been produced in dogs by the method of intrabronchial insufflation of B. friedlaenderi, Type B, and Pneumococcus, Type I. 2. Such dogs as showed evidences of a pulmonary lesion when photographed by x-ray were selected for lung temperature measurements. 3. Measurements of lung temperature were made by means of thermocouples before and during diathermy. 4. The thermocouples which recorded the temperature in the consolidated lobes showed in most instances a more rapid rate of heating during diathermy than those in the normal lobes. The final increase in temperature in the pathological lobes over the normal lobes amounted to slightly more than 1 degrees C. 5. When local heating occurred during diathermy it was of the order of magnitude found in a lung in which the branch of the pulmonary artery supplying it had been clamped. 6. Histological examination of the lungs showed the pathological reaction to consist of intraalveolar exudate composed of polymorphonuclear leucocytes and desquamated alveolar epithelium. In some sections the exudate was sufficient to cause compression and emptying of the alveolar capillaries. 7. The local heating, we believe, depends upon this ischemic state of the smaller vessels. 8. Further evidence for an imparied circulation in the pneumonic lung is furnished by injection preparations in which the uninjected area corresponded exactly to the gross pathological lesion.
Nosocomial diarrhea caused by Salmonella derby infection in two patients on chemotherapy
Authors: Gabi Philippczik, Jürgen Fehrenbaeh, Bernhard Steinbrückner, Kann Potthoff, Alexander Spyridonidis, Albrecht Lindemann, Manfred Kist, Tilman M. Bauer
Journal: Clinical Microbiology and Infection (1999)
The Crown-Gall Potato Disk Bioassay as a Primary Screen for Compounds With Antitumor Activity
Authors: A G Galsky, R Kozimor, D Piotrowski, R G Powell
Journal: JNCI Journal of the National Cancer Institute (1981)

A variety of samples consisting of purified compounds (of various origins) and ethanol extracts from plants were assayed for their activity on the growth and initiation of crown-gall tumors on potato disks. The results demonstrated a high correlation between the ability of these compounds to inhibit the initiation and growth of crown-gall tumors on potato disks and their corresponding activity on the mouse P388 leukemia protocol. Of the 21 compounds tested to date, there were two false-positives and one false-negative.
Requests for Vasectomy: Counselling and Consent
Authors: Roger Hole
Journal: Journal of the Royal Society of Medicine (2001)

Mr Harris and Mr Holmes (October 2001 JRSM, pp. 510-511) are correct in stating that an unwanted pregnancy following a vasectomy failure due to late recanalization ‘can have devastating social and financial consequences’. But their advice that it is sufficient to warn the patient that the (average) risk of such failure is ‘about 1 in 2000 cases’ is, I believe, flawed in two respects. First, it leaves unanswered what sensible advice can be given to a patient who asks what can be done to reduce this risk. Secondly, the term ‘vasectomy’ includes a range of procedures—from the removal of several centimetres of vas (with wide separation of the ends) through division of the vas and separation of the ends by tissue interposition1 to diathermy of the intact vas resulting in an obstructed segment less than 2 mm in length2. The risk of recanalization when the diathermy technique is used must be far greater than the average quoted, and therefore the advice given will be incorrect (and so any consent improperly obtained).

Because of the rarity of recanalization an individual surgeon cannot calculate the risk for the procedure that will be used. But surely the British Association of Urologists ought by now to have collated the results of a large enough number of surgeons, grouped by the type of ‘procedure called vasectomy’ that they use, for a statistically valid estimate of the risk for each procedure to be made. Patients would thereby be better informed and so able to choose a less risky procedure if they wished, and the profession might be less at risk from litigation2,3.
The number of asthma attacks reported by subjects with physician-diagnosed asthma in Italy has increased from 1998-2000 to 2007-2010. Preliminary results
Authors: Lucia Cazzoletti, Leonardo Antonicelli, Lucio Casali, Isa Cerveri, Massimiliano Bugiani, Maria Grazia Panico, Pietro Pirina, Giuseppe Verlato, Roberto de Marco
Journal: European Respiratory Journal (2012)

In Italy, the prevalence of current asthma increased during the last 10 years, but few information are available on the temporal change of asthma severity in the same period.  The present study is aimed at quantifying the temporal change in the number of asthma attacks as a proxy of asthma severity in the last 10 years in the Italian adult population with diagnosed current asthma.  The same screening questionnaire was administered to random samples of 20-44 year-old subjects from the general population in 4 Italian centres (Pavia, Sassari, Turin and Verona) in 1998-2000 (in the frame of the Italian Study on Asthma in Young Adults, ISAYA; response rate 76%) and in 2007-2010 (in the frame of the Gene Environment Interaction in Respiratory Diseases, GEIRD, study; response rate 53%). The number of asthma attacks was modelled by means of a negative binomial model, adjusting for centre, sex, age, drug use and design confounders.  The prevalence of subjects with physician-diagnosed current asthma and at least 1 asthma attack in the last year increased from 2.8% (95%CI:2.5;3.2%) to 4.1% (95%CI:3.6;4.7%). The mean number of asthma attacks in the last year was 3.1 (s.d. 10.1) in ISAYA and 4.4 (s.d. 13.2) in GEIRD. The adjusted relative change in the mean of asthma attacks between the 2 surveys was 1.62 (95%CI:1.16;2.29): subjects with diagnosed current asthma had a 62% higher mean number of attacks in GEIRD with respect to ISAYA.  It needs to be clarified whether this increase in the mean number of asthma attacks is due to an increase in asthma severity, a poor patient compliance or a scarce physician adherence to the prescribing guidelines.
Dosing Strategies of Bone-Targeting Agents—Reply
Authors: Susan L. Greenspan, Subashan Perera, Neil M. Resnick
Journal: JAMA Internal Medicine (2015)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Internal Medicine HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Internal Medicine journal
Tumorigenicity of Nasopharyngeal Carcinoma Hybrid Cell Line&lt;xref ref-type="fn" rid="FN2"&gt;2&lt;/xref&gt;
Authors: T Takimoto, H Ogura, S Ohno, R Umeda, M Hatano
Journal: JNCI Journal of the National Cancer Institute (1984)

The spontaneous production of Epstein-Barr virus (EBV) and tumorigenicity in the BALB/c mutant nude mouse were studied with the use of the following 4 cell lines derived from the human nasopharynx: a) Ad-AH, an 8-azahypoxanthine-resistant epithelioid cell line; b) A2L, an EBV-carrying lymphoblastoid cell line; c) A2L/AH, an EBV-carrying epithelioid hybrid cell line established by fusion of Ad-AH cells with A2L cells; and d) NPC-KT, an EBV-carrying epithelioid hybrid cell line established by fusion of Ad-AH cells with nasopharyngeal carcinoma (NPC) primary culture cells. The NPC-KT hybrid cell line was the only cell line to produce EBV antigens of the lytic cycle and virus particles. Cloning efficiency in agarose was clearly related to tumorigenicity in nude mice. Especially high, frequent tumor formation was observed in the heterotransplantation of NPC-KT hybrid cells that presented poorly differentiated carcinoma, and the tumor cells were positive for EBV-associated nuclear antigen. These NPC-KT hybrid cells maintained the characteristics of a histologic type of NPC tumor cells. Thus experimental systems of NPC were established in vitro and in vivo by the application of NPC-KT hybrid cells to NPC model cells.