Clinical Implications of Genetic Polymorphism of <i>CYP2D6</i> in Mexican Americans
Authors: Deborah L. Flores, Israel Alvarado, Ma-Li Wong, Julio Licinio, David Flockhart
Journal: Annals of Internal Medicine (2004)

Letters1 June 2004Clinical Implications of Genetic Polymorphism of CYP2D6 in Mexican AmericansDeborah L. Flores, MD, Israel Alvarado, MD, Ma-Li Wong, MD, Julio Licinio, MD, and David Flockhart, MDDeborah L. Flores, MDFrom University of California, Los Angeles, Los Angeles, CA 90095-1761; and Indiana University School of Medicine, Indianapolis, IN 46202., Israel Alvarado, MDFrom University of California, Los Angeles, Los Angeles, CA 90095-1761; and Indiana University School of Medicine, Indianapolis, IN 46202., Ma-Li Wong, MDFrom University of California, Los Angeles, Los Angeles, CA 90095-1761; and Indiana University School of Medicine, Indianapolis, IN 46202., Julio Licinio, MDFrom University of California, Los Angeles, Los Angeles, CA 90095-1761; and Indiana University School of Medicine, Indianapolis, IN 46202., and David Flockhart, MDFrom University of California, Los Angeles, Los Angeles, CA 90095-1761; and Indiana University School of Medicine, Indianapolis, IN 46202.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-140-11-200406010-00028-w2 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:Background: Mexican Americans make up 66% of U.S. Hispanics, the country's largest ethnic minority group (1). Few studies report antidepressant treatment in this population, and they have conflicting results (Table).Table. Studies on U.S. Hispanics with Antidepressants Metabolized by CYP2D6*Objective: To perform an 8-week, prospective, double-blind trial investigating the pharmacogenetics of antidepressant response to desipramine or fluoxetine.Results: We describe 2 Mexican-American women homozygous for CYP2D6*4 with resultant toxic levels of desipramine and severe adverse drug reactions at minimal doses.Case Reports: JR and IA are Mexican-American ...References1. U.S. Census Bureau 2001. Accessed at www.census.gov on 1 November 2003. Google Scholar2. Marcos LR, Cancro R. Pharmacotherapy of Hispanic depressed patients: clinical observations. Am J Psychother. 1982;36:505-12. [PMID: 7158673] CrossrefMedlineGoogle Scholar3. Gaviria M, Gil AA, Javaid JI. Nortriptyline kinetics in Hispanic and Anglo subjects. J Clin Psychopharmacol. 1986;6:227-31. [PMID: 3734142] CrossrefMedlineGoogle Scholar4. Alonso M, Val E, Rapaport MH. An open-label study of SSRI treatment in depressed Hispanic and non-Hispanic women [Letter]. J Clin Psychiatry. 1997;58:31. [PMID: 9055837] CrossrefMedlineGoogle Scholar5. Bertilsson L, Dahl ML, Dalen P, Al-Shurbaji A. Molecular genetics of CYP2D6: clinical relevance with focus on psychotropic drugs. Br J Clin Pharmacol. 2002;53:111-22. [PMID: 11851634] CrossrefMedlineGoogle Scholar6. Mendoza R, Wan YJ, Poland RE, Smith M, Zheng Y, Berman N, et al . CYP2D6 polymorphism in a Mexican American population. Clin Pharmacol Ther. 2001;70:552-60. [PMID: 11753272] CrossrefMedlineGoogle Scholar7. Licinio J, Alvarado I, Wong ML. Will pharmacogenomics guide clinical practice? [Editorial]. Pharmacogenomics J. 2002;2:71. [PMID: 12049176] CrossrefMedlineGoogle Scholar8. Chou WH, Yan FX, de Leon J, Barnhill J, Rogers T, Cronin M, et al . Extension of a pilot study: impact from the cytochrome P450 2D6 polymorphism on outcome and costs associated with severe mental illness. J Clin Psychopharmacol. 2000;20:246-51. [PMID: 10770465] CrossrefMedlineGoogle Scholar9. Mischoulon D. Management of major depression in Hispanic patients. Directions in Psychiatry. 2000;20:275-85. Google Scholar Author, Article, and Disclosure InformationAffiliations: From University of California, Los Angeles, Los Angeles, CA 90095-1761; and Indiana University School of Medicine, Indianapolis, IN 46202. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byIdentification of CYP2D6 impaired functional alleles in Mexican AmericansThe Effect of CYP2D6 Polymorphisms on Dextromethorphan Metabolism in Mexican AmericansTranslating pharmacogenomics discoveries into clinical practice: the role of curated databasesDepression, antidepressants and suicidality: a critical appraisal 1 June 2004Volume 140, Issue 11Page: W-48-W49KeywordsAdverse reactionsAllelesDepressionDrug administrationDrug metabolismDrugsGenotypingHispanic peopleTachycardiaVision ePublished: 1 June 2004 Issue Published: 1 June 2004 Copyright & PermissionsCopyright © 2004 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...