tbuckley/cabot-search huggingface dataset:
Effect of obstructive lung disease on mosaic attenuation patern in CTEPH patient
Authors: Emel Eryuksel, Bedrettin Yildizeli, Cagatay Cimsit, Sehnaz Olgun Tandogdu, Sait Karakut
Journal: European Respiratory Journal (2013)

Pulmonary endarterectomy (PEA) is a choice of treatment in chronic thromboembolic pulmonary hypertension (CTEPH). Mosaic attenuation pattern (MAP) is a radiological finding in CTEPH and there are equivocal findings on its use to determine the intensity of the disease. Obstructive lung diseases can cause MAP and increase the extent of this finding in CTEPH patients. The effect of obstructive disease on the preoperative and postoperative pulmonary artery pressures (PAP) and pulmonary vascular resistance (PVR) in CTEPH patients with equal MAP findings are studied.  Forty-one CTEPH patients who underwent PEA with equal MAP findings determined by high resolution CT (HRCT) scoring were retrospectively evaluated. Lung function tests were used to group the patients as obstructive and non-obstructive. Preoperative and postoperative PAP and PVR values were calculated and the hemodynamic relationship between MAP and CTEPH was evaluated.  Patients’ MAP values were equal (18/18). No difference was found between the obstructive group (Group I, n=11) and non-obstructive group (Group II, n=30) based on preoperative PAP (65 vs. 81, p=0.13). Preoperative PVR was significantly lower in Group I (598 vs. 880, p  Preoperative PVR and postoperative PAP are lower in CTEPH patients with obstructive disease and MAP. Obstructive pattern is not a risk in PEA candidates with high MAP scores, and this group of CTEPH patients benefit more from PEA.
Phase 2 study of ABT-751 in patients with refractory metastatic colorectal carcinoma (CRC)
Authors: A. B. Benson, H. L. Kindler, D. Jodrell, A. Hagey, A. I. Coates, K. A. Meek, P. Cernohous, G. B. Gordon
Journal: Journal of Clinical Oncology (2005)

3537 Background: ABT-751, an oral antimitotic agent that binds to the colchicine site of β-tubulin and prevents microtubule polymerization, has shown antitumor activity in CRC in xenograft models, including HCT-15, a human colon carcinoma-derived cell line in which paclitaxel and vincristine were ineffective. Minor responses to ABT-751, including one partial response, were seen in CRC patients in phase 1 studies. Methods: This phase 2, multi-center study evaluated the safety and efficacy of ABT-751 in patients with metastatic CRC (N = 49) refractory to irinotecan or oxaliplatin [single refractory (SR) arm, n = 14], or irinotecan and oxaliplatin [double refractory (DR) arm, n = 35]. For each cycle, patients received 200 mg ABT-751 orally once daily for 21 days followed by a 7-day break. Time to disease progression (TTP) was analyzed using Kaplan-Meier Methods: CT scans were obtained every 2 cycles. Patient response was evaluated using RECIST. Results: The median duration of therapy was 2 cycles (range 1–8). 57% of patients experienced Grade 3 or 4 toxicities. 18/49 (37%) subjects experienced Grade 3 or 4 toxicities considered probably or possibly related to study drug, including 15/35 in the DR arm and 3/14 in the SR arm [most common = asthenia (12%), anorexia (10%), neuropathy (8%), and constipation (6%)]. Median TTP was 2.1 months (95% CI = 1.9–2.6). Median TTP by study arm was 2.0 months for the DR arm (95% CI = 1.8–2.3) and 3.8 months for the SR arm (95% CI = 2.0–3.9). Three patients remain on study in the SR arm, including 1 patient in Cycle 6. One patient discontinued after exhibiting stable disease through 8 cycles. No complete or partial responses have been observed to date. Conclusions: ABT-751 was well tolerated in CRC patients. Despite preclinical and phase 1 data suggesting activity, ABT-751 was not active as a single-agent in patients with multiple refractory metastatic CRC. Phase 2 studies in patients with renal, breast, and lung carcinoma are ongoing. Author Disclosure Employment or Leadership Consultant or Advisory Role Stock Ownership Honoraria Research Funding Expert Testimony Other Remuneration Abbott Laboratories Abbott Laboratories
Obsessive-compulsive disorder among patients with anorexia nervosa and bulimia nervosa
Authors: A Thiel, A Broocks, M Ohlmeier, G E Jacoby, G Schüssler
Journal: American Journal of Psychiatry (1995)

The present study sought to determine the prevalence of obsessive-compulsive disorder among patients with eating disorders.Ninety-three women who met DSM-III-R criteria for anorexia nervosa or bulimia nervosa were investigated by using a semistructured diagnostic interview, the Yale-Brown Obsessive Compulsive Scale, and the Eating Disorder Inventory.Thirty-four patients (37%) met the DSM-III-R criteria for obsessive-compulsive disorder and also had a clinically significant score of 16 or higher on the Yale-Brown scale. These patients also had significantly higher, and hence pathological, mean scores on five of eight Eating Disorder Inventory scales than patients with eating disorders without concomitant obsessive-compulsive disorder.These results suggest that there is a high prevalence of obsessive-compulsive disorder among patients with anorexia and bulimia nervosa and that this prevalence may be correlated with the severity of the eating disorder.
Amplified fragment length polymorphism analysis of human clinical isolates of Mycobacterium haemophilum from different continents
Authors: L.E.S. Bruijnesteijn van Coppenraet, P.H.M. Savelkoul, N. Buffing, M.W. van der Bijl, J. Woudenberg, J.A. Lindeboom, T.E. Kiehn, F. Haverkort, Z. Samra, E.J. Kuijper
Journal: Clinical Microbiology and Infection (2009)
A Study by an Open Circuit Method of the Intrapulmonary Mixture of Inspired Air
Authors: M. R. Becklake
Journal: Thorax (1951)

Of the various pulmonary function tests used by the clinician in the assessment of such conditions as emphysema, the study of inequality of distribution of inspired air to the lung spaces has only been developed recently.Several techniques have been described whereby disturbances of this sort may be detected (Birath, 1944;Bates and Christie, 1950;Robertson, Siri, and Jones, 1950;Bateman, 1950).In their work on the development of an open circuit method of measuring functional residual air Cournand, Baldwin, Darling, and Richards (1941) had noticed that the percentage of alveolar nitrogen after seven minutes' pure oxygen breathing tended to be higher in emphysematous subjects than in normal controls.This suggested to them that tidal air was less effective in washing out the lung spaces of emphysematous subjects, and furthermore that in the emphysematous subject the tidal air was probably unevenly distributed to the lung spaces.Consequently they adapted their open circuit method for measuring functional residual air (F.R.A.) in such a way that it would assess this lack of evenness of intrapulmonary distribution of inspired air.By collecting expired air in a series of experiments, each of a different duration, Darling, Cournand, and Richards (1944) were able to follow the rate of nitrogen elimination from the lungs during oxygen breathing.From the amount of nitrogen washed out of the lungs, an estimate was made of the percentage nitrogen in the air remaining in the lung.These results were plotted against the number of breaths, and compared with a predicted curve.The latter was calculated from a formula which took into account the tidal air, pulmonary dead space, and functional residual air of the subject, and assumed that with each breath a volume of air equal to the tidal air minus the pulmonary dead space (effective tidal air) was distributed evenly throughout the lung spaces.The principal disadvantage of this method was that a mixing study of five points required six experiments (with about half-an-hour's interval between each to allow re-aeration of the lungs and tissues) so that the total period over which the patient was studied amounted to about three hours.During so long a period fortuitous changes in tidal air and respiratory level might invalidate comparisons between different experiments.The aim of the present study was to develop a method in which the relevant information could be obtained in a single experiment.
Combined Therapy With BRD4 Antagonist and FLT3 Inhibitor Exerts Synergistic Activity Against Cultured and Primary AML Blast Progenitors Expressing FLT-ITD
Authors: Melissa Rodriguez, Warren Fiskus, Sunil Sharma, Jun Qi, John A Valenta, Leasha J Schaub, Bhavin Shah, Santhana Devaraj, Swaminathan Padmanabhan Iyer, James E Bradner, Kapil N. Bhalla
Journal: Blood (2013)
BODY BUILD IN INFANTS
Authors: Harry Bakwin, Ruth Morris Bakwin
Journal: Journal of Clinical Investigation (1931)

This series is made up of 2 groups of infants which will hereafter be designated as Group A and Group B. DESCRIPTION OF GROUP A INFANTSGroup A consists of 475 infants, most of whom were born at the Fifth Avenue Hospital and observed repeatedly in a special clinic.A small number of patients from private practice (25 infants measured 42 times) are included in this group.With few exceptions the income of the parents varied only slightly, ranging between $30 and $35 per week (in 1929).Most of the infants were partially or completely breast-fed from 3 to 6 months.All patients from private practice and all those attending regularly the special clinic at the Fifth Avenue Hospital received cod liver oil and orange juice after the age of 3 weeks, egg yolk, and vegetable or cereal by the fourth month.All infants used in this study were born in the United States.In order to study the influence of race on the proportions of the external dimensions of the body, Group A infants were divided into 4 groups by descent, North European, consisting of Irish, Scotch, English, German, Scandinavian and Finnish (234 infants); Central European, 0 U) U) U) U) U) * C14 10 ON Xo ON 47 a0 C-i U) V C-r-.M-4 --4 -- '.t o-4 o 0 -4o U) -4 !o00 00 V U) U) U) U) 00 C-C-C-I t-C- It U) ) VO Vo
Abstract 10943: Predictors of Psychological Distress in Patients with Recurrent Symptomatic Atrial Fibrillation
Authors: Pamela McCabe, Susan A Barnason
Journal: Circulation (2010)

Introduction: Atrial fibrillation (AF) is a life complicating illness associated with psychological distress. As AF prevalence grows 2.5 fold to 8 million by 2050, interventions to help patients ma...
And now, e-publication bias
Authors: A. K. Jakobsen, R. Christensen, R. Persson, E. M. Bartels, L. E. Kristensen
Journal: BMJ (2010)

In open access publishing scholarly communication is made available free of charge on the internet. In biomedical research, authors or sponsors often pay a fee to a publisher to enable immediate free online access.1 2 A few journals operate entirely under this model, whereas others use a hybrid model allowing authors to choose between subscription access and author-paid …
Elevated Expression of Lipoprotein-Associated Phospholipase A2 in Calcific Aortic Valve Disease
Authors: Ablajan Mahmut, Marie-Chloé Boulanger, Diala El Husseini, Dominique Fournier, Rihab Bouchareb, Jean-Pierre Després, Philippe Pibarot, Yohan Bossé, Patrick Mathieu
Journal: Journal of the American College of Cardiology (2013)
Biofilm development by clinical strains of non-pigmented rapidly growing mycobacteria
Authors: N.Z. Martín-de-Hijas, D. García-Almeida, G. Ayala, R. Fernández-Roblas, I. Gadea, A. Celdrán, E. Gómez-Barrena, J. Esteban
Journal: Clinical Microbiology and Infection (2009)
Increased duodenal iron absorption through up‐regulation of divalent metal transporter 1 from enhancement of iron regulatory protein 1 activity in patients with nonalcoholic steatohepatitis
Authors: Toshifumi Hoki, Koji Miyanishi, Shingo Tanaka, Kohichi Takada, Yutaka Kawano, Akira Sakurada, Masanori Sato, Tomohiro Kubo, Tsutomu Sato, Yasushi Sato, Rishu Takimoto, Masayoshi Kobune, Junji Kato
Journal: Hepatology (2015)

Increased hepatic iron accumulation is thought to be involved in the pathogenesis of nonalcoholic steatohepatitis (NASH). Hepatic iron accumulation, as well as oxidative DNA damage, is significantly increased in NASH livers. However, the precise mechanism of iron accumulation in the NASH liver remains unclear. In this study, 40 cases with a diagnosis of NASH (n = 25) or simple steatosis (SS; n = 15) by liver biopsy were enrolled. An oral iron absorption test (OIAT) was used, in which 100 mg of sodium ferrous citrate was administered to each individual. The OIAT showed that absorption of iron from the gastrointestinal (GI) tract was increased significantly in NASH patients, compared to SS and control subjects. Iron reduction therapy was effective in patients with NASH, who exhibited iron deposition in the liver and no alanine aminotransferase improvement after other therapies (n = 9). Serum hepcidin concentration and messenger RNA (mRNA) levels of divalent metal transporter 1 (DMT1) also were significantly elevated in patients with NASH. OIAT results were correlated with grade of liver iron accumulation and DMT1 mRNA levels. Then, we demonstrated that DMT1 mRNA levels increased significantly in Caco-2/TC7 cell monolayers cultured in transwells with serum from NASH patients. An electrophoresis mobility shift assay showed activation of iron regulatory protein (IRP) in those cells, and IRP1 small interfering RNA clearly inhibited the increase of DMT1 mRNA levels.In spite of elevation of serum hepcidin, iron absorption from the GI tract increased through up-regulation of DMT1 by IRP1 activation by humoral factor(s) in sera of patients with NASH.
Genomic Profiling of Cancers of Unknown Primary Site
Authors: Young E. Whang, D. Neil Hayes
Journal: JAMA Oncology (2015)

Jeffrey S. Ross, MD; Kai Wang, MD, PhD; Laurie Gay, PhD; Geoff A. Otto, PhD; Emily White, BS; Kiel Iwanik, BS; Gary Palmer, MD; Roman Yelensky, PhD; Doron M. Lipson, PhD; Juliann Chmielecki, PhD; Rachel L. Erlich, PhD; Andrew N. Rankin, PhD; Siraj M. Ali, MD, PhD; Julia A. Elvin, MD, PhD; Deborah Morosini, MD; Vincent A. Miller, MD; Philip J. Stephens, PhD
Abstract 2444: Demonstration of Colorfully Visualized 3D Thickness of Left Atrial Myocardiun Obtained by 64ch Multi-detector CT: Implications for Catheter Ablation of Atrial Fibrillation
Authors: Junichi Saito, Akira Yoshii, Yoshiharu Ayabe, Masahiko Saito, Yasuo Tokoro, Natsuko Kamiya, Yutaka Kawamura, Katsuyuki Kobayashi, Nami Nishimura, Kazuya Iwata, Masaoki Nishimoto, Masao Nishimura
Journal: Circulation (2007)
Sun protection factor measurement of sunscreens is dependent on minimal erythema dose
Authors: None Damian, None Halliday, None StC.barnetson
Journal: British Journal of Dermatology (1999)

This study investigates the influence of skin colour and minimal erythema dose (MED) on the in vivo determination of sunscreen sun protection factors (SPFs). The MEDs of groups of 10-20 subjects were measured on the lower back with a 1000-W solar-simulated xenon arc lamp. Five sunscreens, with commercially measured SPFs ranging from 4 to 30 + were then tested on the different groups, and their SPFs were correlated with volunteers' MEDs. We found that the sunscreens had higher SPF values when tested on subjects with lower MEDs and paler skin. The SPF values obtained with our ultraviolet (UV) source were lower than the SPF values reported with commercially used solar simulators. We conclude that while SPF tests with artificial UV sources and pale-skinned volunteers can and should be used to rank the efficacy of various sunscreens in preventing sunburn, they should not be interpreted as measures of a sunscreen's absolute level of sun protection. Factors such as the differences in skin colour and MED between subjects used for SPF testing and the general population, the spectral differences between sunlight and artificial UV, as well as the tendency of the public to apply only small amounts of sunscreen and to re-apply it infrequently, mean that laboratory and sunlight SPFs may be markedly different.
Depressive distress among homosexually active African American men and women
Authors: S D Cochran, V M Mays
Journal: American Journal of Psychiatry (1994)

Although early surveys of psychological adjustment among gay men and lesbians suggest only minor and not clinically relevant differences from heterosexual populations, concerns about psychiatric morbidity associated with HIV infection have renewed interest in the prevalence of psychological distress in this population, particularly among gay men. These later studies have focused primarily on white men. However, research indicates higher crude prevalence rates of psychological distress in community-drawn samples of African American subjects than in white subjects and also higher rates in women than in men. The authors examined rates of depressive distress and suicidal thoughts among homosexually active African American men and women who might be especially at risk for psychiatric morbidity due to multiple stigmatized social statuses.
Abstract 3549: Regression of Myocardial Hypertrophy After Aortic Valve Replacement: Faster In Women?
Authors: George Petrov, Vera Regitz-Zagrosek, Elke B Lehmkuhl, Elke Dworatzek, Shokufeh Mahmoodzadeh, Thomas Krabatsch, Roland Hetzer
Journal: Circulation (2009)
Short term effects of chest physiotherapy in children with cystic fibrosis assessed by a new lung function test
Authors: Chiara Abbas, Florian Singer, Carmen Casaulta, Philipp Latzin
Journal: European Respiratory Journal (2012)

Background: No lung function test exists that is able to assess short-term effects of physiotherapeutic treatment (PT) in children with Cystic Fibrosis (CF). We recently developed a tidal single-breath washout (SBW) using two tracer gases to measure ventilation inhomogeneity (VI).  Aims: We assessed whether this new SBW test is able to measure short-term effects of PT and inhalation.  Methods: Children with CF (n=25) between 6 and 16 years performed lung-function assessments prior to and after inhalation and PT. Assessments consisted of a double tracer gas SBW (DTG-SBW) and spirometry. DTG contained sulfur hexafluoride (SF6) and helium (He), and was inhaled during tidal breathing. A side-stream ultrasonic flowmeter measured molar mass. DTG-SBW outcome was percentage of expired volume where expired molar mass equals inspired molar mass, reflecting inspired ratio of SF6 and He (IPDTG).  Results: After intervention IPDTG decreased from 66.5% (±25.8) to 59.7% (±25.4) resulting in a mean difference of -7.3% (95%CI -12.9 to -1.8) and MEF25-75 increased from 1.41 L/s to 1.62 L/s resulting in a mean difference of 0.19 L/s (95%CI 0.02 to 0.37). In a post-hoc subgroup analysis we found that the DTG-SBW is more suited to detect changes in VI in patients with mild CF lung disease (n=14, FEV1 z-score >-2), whereas spirometry indexes increased only in patients with moderate CF lung disease (n=11, FEV1 z-score   Conclusion: The DTG-SBW seems to be a promising test to detect short-term effects of physiotherapy and inhalation.
Abstract P59: Effect Of Implementation Of The 2005 Resuscitation Guidelines On Quality Of Cardiopulmonary Resuscitation (CPR) And Survival
Authors: Theresa M Olasveengen, Eystein Vik, Petter Andreas Steen, Lars Wik, Kjetil Sunde
Journal: Circulation (2008)

Background: ACLS providers have been shown to deliver inadequate CPR with long intervals without chest compressions. Several changes made to the 2005 CPR Guidelines were intended to reduce these in...
Abstract 17175: Caveolin-3 Suppresses Late Sodium Current by Inhibiting Nnos-Dependent S-Nitrosylation of Scn5a
Authors: Jianding Cheng, Carmen Valdivia, Ravi C. Balijepalli, Jonathan C. Makielski
Journal: Circulation (2010)

Background: Mutations in CAV3 —encoding Caveolin-3 (Cav3) have been implicated in arrhythmia syndromes such as long QT Syndrome type 9 (LQT9) and sudden infant death syndrome (SIDS). When coexpressed with SCN5A —encoded Nav1.5, these mutations result in a gain-of-function molecular phenotype by increasing late sodium current (I Na). Objetive To determine the mechanism by which LQT9-causing mutant Cav3-F97C affects the function of Nav1.5. Methods and Results: HEK-293 cells expressing SCN5A and Cav3-F97C resulted in a 2-fold increase in late I Na compared to Cav3-WT and this effect was reversed by the neural nitric oxide synthase (nNOS) inhibitor L-NMMA. Based on these findings we hypothesized that the nNOS complex was involved in the modulatory effect of Cav3 on Nav1.5 channels. A Nav1.5 macromolecular complex was established in HEK-293 cells by transiently expressing SCN5A, α1-syntrophin (SNTA1), nNOS, and Cav3. Compared with Cav3-WT, Cav3-F97C had significantly larger peak I Na amplitudes, and showed a 3...
Analysis of the association between protein C gene single nucleotide polymorphism and pulmonary thromboembolism in Chinese population
Authors: Yijie Zhang, Yafang Miao, Kebing Cheng, Xiaoyue Tan, Jinming Liu
Journal: European Respiratory Journal (2012)

Background : We investigated the role of protein C (PC) polymorphism in patients with PTE in order to find out the correlation between its polymorphism and the susceptibility of the Chinese population to develop PTE.   Methods : Sixty three consecutive patients with PTE were enrolled as the investigated group and eighty six healthy people as the control group. C/T at the position of 2405 and A/G at the position of 2418in the PC gene promoter region were detected through polymerase chain reaction-restriction fragment length polymorphism analysis.   Results:  (1) The results suggested that the genotype frequencies of the two SNPs when combined together were not significantly different between two group (P > 0.05).However, the allele frequency of the C2405T SNP was significantly different between the case and control group. The frequency of T allele in the PTE group was higher. (2) These results suggested that there were six different kinds of genotype distribution (TA - TA, TA - CA, TA - CG, CG - CG, CA - CG, CA - CA) and three different kinds of haplotype (TA, CG, CA).   Conclusions:  These results suggest that the two polymorphisms present in the control region of PC gene are associated with an increased susceptibility to PTE in the Chinese population. The2405T allele may be a possible risk factor for the development of PTE while the C allele may probably be a protective factor of PTE.Moreover, the TA haplotype may also be associated with an increased risk for developing PTE.
Soraphen A: A broad-spectrum antiviral natural product with potent anti-hepatitis C virus activity
Authors: George Koutsoudakis, Inés Romero-Brey, Carola Berger, Gemma Pérez-Vilaró, Paula Monteiro Perin, Florian Wolfgang Rudolf Vondran, Markus Kalesse, Kirsten Harmrolfs, Rolf Müller, Javier P. Martinez, Thomas Pietschmann, Ralf Bartenschlager, Mark Brönstrup, Andreas Meyerhans, Juana Díez
Journal: Journal of Hepatology (2015)