A Comparative Study of the Choleretic Effect of Bile Salts and Oleic Acid and Bile Salts
Authors: Reuben Finkelstein, Emanuel W. Lipschutz
Journal: Annals of Internal Medicine (1933)

Article1 May 1933A Comparative Study of the Choleretic Effect of Bile Salts and Oleic Acid and Bile SaltsREUBEN FINKELSTEIN, M.D., F.A.C.P., EMANUEL W. LIPSCHUTZ, M.D.REUBEN FINKELSTEIN, M.D., F.A.C.P.Search for more papers by this author, EMANUEL W. LIPSCHUTZ, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-6-11-1465 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptFor the past year we have employed a mixture of oleic acid and bile salts for the treatment of patients suffering from various forms of gall-bladder disease. The results obtained, which were reported elsewhere15were gratifying in a large number of cases. We then decided to undertake an experimental study of the choleretic effect of bile salts and of oleic acid with bile salts to ascertain whether oleic acid which has a direct action on the gall-bladder also enhances the well known choleretic effect of bile salts. Theoretically, as will be shown later, it appeared plausible that such would be...Bibliography1 STERNERBARTLELYON RFHJBB: The cholagogue effect of the intravenous injection of sodium dehydrocholate, with résumé of literature on bile salt metabolism, Am. Jr. Med. Sci., 1931, clxxxii, 822-839. CrossrefGoogle Scholar2 COPHERKODAMA GHS: The regulation of the flow of bile and pancreatic juice into the duodenum, Arch. Int. Med., 1926, xxxviii, 647-653. CrossrefGoogle Scholar3 WHITAKER LR: Diagnosis of gall-bladder disease: application of recent advances in physiology, Jr. Am. Med. Assoc., 1927, lxxxviii, 1791-1796. Google Scholar4 IVY AC: Hormone mechanism of gall-bladder contraction and evacuation, Am. Jr. Surg., 1929, vii, 455-459. CrossrefGoogle Scholar5 IVYOLDBERG ACE: Hormone mechanism for gall-bladder contraction and evacuation, Am. Jr. Physiol., 1928, lxxxvi, 599-613. CrossrefGoogle Scholar6 CRANDALL LA: Mechanisms of the contraction and evacuation of the gall-bladder, Arch. Int. Med., 1931, xlviii, 1217-1224. CrossrefGoogle Scholar7 LIPSCHUTZ EW: A new diagnostic and therapeutic aid in biliary tract disease, Med. Jr. and Rec., 1927, cxxv, 321-322. Google Scholar8 STEWARTRYAN WHEJ: Cholecystographic studies after administration of some of the popular cholagogues, Am. Jr. Roentgenol. and Radium Therap., 1928, xix, 341-343. Google Scholar9 BAYLISSSTARLING WMEH: The mechanism of pancreatic secretion, Jr. Physiol., 1902, xxviii, 325-353. CrossrefGoogle Scholar10 MELLANBY J: Bile salts and secretin as cholagogues, Jr. Physiol., 1928, lxiv, 331-340. CrossrefGoogle Scholar11 IVY AC: Newer physiology of the gastrointestinal tract, Am. Jr. Med. Sci., 1927, clxxiii, 453-460. Google Scholar12 WAKEFIELDPOWELSONMCVICAR EGHPC: The use of a sodium salt of dehydrocholeic acid (decholin) as a choleretic, ANN. INT. MED., 1929, iii, 572-577. Google Scholar13 MCCLUREWETMOREREYNOLDS CWASL: Physical characters and enzymatic activities of duodenal contents; findings during gastric digestion in normal young men, Jr. Am. Med. Assoc., 1921, lxxvii, 1468-1469. Google Scholar14 OKADASAKURAIIMAZUKURAMOCHI SETK: Pancreatic function; quantitative estimation of pancreatic secretion, Arch. Int. Med., 1928, xlii, 270-281. CrossrefGoogle Scholar15 FINKELSTEINLIPSCHUTZ RSW: Final report on the therapeutic effect of oleic acid and bile salts in gall-bladder disease, Clin. Med. and Surg., 1933, xl, 78-80. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Brooklyn, New York*Received for publication June 3, 1932.†From the Gastrointestinal Department of the Beth-El Hospital. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byStudies on the cholagogue and choleretic effects of bile acids as compared with oleic acidStudies in human biliary physiology 1 May 1933Volume 6, Issue 11Page: 1465-1473KeywordsBileChemical analysisPatientsSalts ePublished: 1 December 2008 Issue Published: 1 May 1933 PDF downloadLoading ...