tbuckley/cabot-search huggingface dataset:
Catalan parliament pushes for legalisation of cannabis as therapy
Authors: Xavier Bosch
Journal: BMJ (2001)

All five political parties in the Catalan parliament in Spain have signed a proposal to legalise the use of cannabis for therapeutic purposes. The agreement asks the Catalan government to negotiate with the Spanish authorities so that cannabis—either as a drug or as a standardised extract of the plant—may be used to treat medical disorders.

Once the bill is approved in the Catalan parliament, it may be submitted to the Spanish parliament for discussion and eventual voting.

The initiative came from a collective of 300 women with breast cancer called the “Agata group” (after Saint Agata, who had her breasts removed under torture) and from a journalist, Nuria Nogueras, who recently died of the disease and who found the drug helpful during chemotherapy. …
Can itch-related visual stimuli alone provoke a scratch response in healthy individuals?
Authors: D.M. Lloyd, E. Hall, S. Hall, F.P. McGlone
Journal: British Journal of Dermatology (2012)

The sensation of itch and the scratch response elicited by application of histamine are enhanced by itch-related visual cues in people with existing skin conditions and, to a lesser extent, in healthy controls. We tested whether visual cues alone could generate feelings of itch and provoke a scratch response in healthy volunteers. A secondary aim was to assess whether the content of some pictures evoked these sensations more effectively. Thirty participants viewed static images that were either itch-related (e.g. ants, fleas or skin conditions) or neutral (e.g. butterflies or healthy skin). These were further separated by picture type into 'skin contact' (e.g. ants crawling on the hand or a butterfly on a finger), 'skin response' (e.g. scratching an insect bite or washing the hands) or 'context only' (e.g. viewing midges or birds flying). The sensation of itch was successfully generated using itch-related pictures, with higher self-reports of itch in answer to the questions 'How itchy do you feel?' and 'How itchy do you think the person in the picture feels?', compared with viewing neutral pictures (P<0·001), and these measures correlated (P≤ 0·003). Participants also scratched themselves more when viewing itch-related pictures than when viewing neutral ones (P<0·001). The interaction with picture type was significant, with more scratching behaviour recorded when viewing pictures depicting others scratching (P=0·01). This study demonstrates the impact of visual cues in eliciting sensations of itch and provoking a scratch response, and may provide behavioural evidence linking contagious itch to the mirror neuron system.
The African Republic of Liberia and the Belgian Congo Based on the Observations Made and Material Collected During the Harvard African Expedition, 1926-1927.
Authors: Richard P. Strong, George C. Shattuck, Max Theiler, Loring Whitman, Joseph C. Bequaert, Glover M. Allen, David H. Linder, Harold J. Coolidge
Journal: JAMA (1931)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Abstract 1760: Tumor-specific targeting of the NAD metabolome with β-lapachone and NamPT inhibition
Authors: Zachary Moore, David A. Boothman
Journal: Cancer Research (2014)

Abstract Cancer cells require increased NAD+ synthesis to support anabolic metabolism, to sustain signaling processes such as sirtuin activity and ADP-ribosylation, and to maintain redox balance. Inhibitors of Nicotinamide phosphoribosyltransferase (NamPT), the rate-limiting step in NAD+ biosynthesis, have modest anti-tumor activity in monotherapy in vitro and in vivo, but failed clinical trials due to a lack of tumor specificity attributed to the necessity of NAD+ synthesis in normal proliferating cells. We found that the tumor specificity and efficacy of NamPT inhibition can be greatly increased when small molecule NamPT inhibitors, such as FK866, are used in combination with the NQO1 bioactivated therapeutic ß-lapachone (ß-lap). Most solid tumor cells overexpress NQO1, which catalyzes a futile redox cycle with ß-lap, resulting in the formation of a burst of reactive oxygen species (ROS). This results in substantial DNA single strand breaks and base damage in a tumor-specific manner, which hyperactivates poly(ADP-ribose) polymerase-1 (PARP-1), a DNA repair enzyme that utilizes NAD+ to generate poly(ADP-ribose) (PAR)-protein moieties. Rapid NAD+ and ATP loss occurs and tumor cells die through programmed necrosis. PARP-1-mediated NAD+ depletion caused by ß-lap treatment synergizes with reduced NAD+ synthesis as a result of FK866-mediated NamPT inhibition. Enhanced cancer cell death in terms of loss of viability and clonogenicity at lower ß-lap doses was noted, while tumor specificity for NQO1 overexpressing cells was maintained. With combination treatment, cells are primed for ROS-mediated damage due to reduced glutathione and NAD(P)+ levels, they are unable to recover ATP, NAD+, and NADP+ synthesis even after only a 2 hour treatment, and they rapidly die through a caspase-independent mechanism. This therapeutic approach is highly effective against a variety of tumor cell lines from pancreatic, breast, and non-small cell lung, and is expected to improve the efficacy and tumor specificity of both of these drugs by allowing their use at lower doses in vivo. These studies were supported by an AACR/PanCan Innovator Award and NIH R01 CA102972 to DAB. Citation Format: Zachary Moore, David A. Boothman. Tumor-specific targeting of the NAD metabolome with β-lapachone and NamPT inhibition. [abstract]. In: Proceedings of the 105th Annual Meeting of the American Association for Cancer Research; 2014 Apr 5-9; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2014;74(19 Suppl):Abstract nr 1760. doi:10.1158/1538-7445.AM2014-1760
239. Human Myoblast Deimmortalization Using Tat-Mediated Cre Recombinase Delivery
Authors: Nicolas J. Caron, Marie-Eve Ducharme, Philippe Mills, Simon P. Quenneville, Jacques P. Tremblay
Journal: Molecular Therapy (2004)

The reduced proliferating capacity of myoblasts isolated from Duchenne muscular dystrophy (DMD) patients limits our capacity to genetically modify and proliferate them in vitro for their use in autologous transplantation. Previously, our research group has successfully immortalized and extensively proliferated DMD myoblasts using the SV-40 Large T antigen (TAg) and hTERT1,2. Using a retroviral vector coding for TAg flanked by LoxP sites, immortalization reversal can be performed by Cre delivery. To circumvent the requirement for an additional infection, we used a Tat-Cre recombinase fusion protein to exert the recombination necessary for immortalization reversal. Tat-Cre intracellular transduction produced site-specific recombination and excision of the TAg. To facilitate the TAg excision process, cell lines containing a single immortalizing integrative event were generated. Using these cell lines, we demonstrate that by optimizing the delivery using a high concentration Tat-Cre protein, by co-incubating with chloroquine and by selecting against cells containing copies of the unrecombined vector, complete TAg removal could be achieved with a single 1 h treatment. In addition to the molecular evidence demonstrating immortalizing cassette removal, TAg excision also resulted in growth arrest within 2 days. The resulting cell culture could be maintained for at least 2 weeks. These results indicate that the intracellular delivery of a recombinant Tat-Cre protein could be a useful tool for a variety of applications that necessitate the manipulation of cells in culture.
A rare heterozygous TRAF6 variant is associated with hypohidrotic ectodermal dysplasia
Authors: S.A. Wisniewski, W.H. Trzeciak
Journal: British Journal of Dermatology (2012)

Mutations in the genes encoding components of the tumour necrosis factor (TNF)-α-like pathway cause hypohidrotic ectodermal dysplasia (HED). It has been postulated that the TNF receptor-associated factor 6 (TRAF6) is also involved in this pathway.To investigate mutations in the TRAF6 gene in an individual with HED.Genetic analysis was performed on TRAF6 in a patient with HED, her parents, her sister and 150 ethnically matched, healthy individuals.In the patient, sequencing analysis of one DNA strand revealed a deletion of eight nucleotides (c.1074-1081delCAATTTG) in the 5' fragment of the last exon of TRAF6, while no deletion was detected in the other DNA strand indicating a heterozygous mutation. No such sequence abnormality was detected in the patient's parents and her sister.This is the first report of a heterozygous TRAF6 sequence variant associated with symptoms typical of HED.
Guiding the Guardians and Other Participants in Shared Decision Making
Authors: Muriel R. Gillick
Journal: JAMA Internal Medicine (2015)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Internal Medicine HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Internal Medicine journal
Treatment with bortezomib‐based regimens improves overall response and predicts for survival in patients with primary or secondary plasma cell leukemia: Analysis of the Greek myeloma study group
Authors: Eirini Katodritou, Evangelos Terpos, Charikleia Kelaidi, Maria Kotsopoulou, Sossana Delimpasi, Marie‐Christine Kyrtsonis, Argiris Symeonidis, Nikos Giannakoulas, Aikaterini Stefanoudaki, Dimitrios Christoulas, Christina Chatziaggelidou, Vassiliki Gastari, Nikos Spyridis, Evgenia Verrou, Pavlina Konstantinidou, Kostas Zervas, Meletios A. Dimopoulos
Journal: American Journal of Hematology (2013)

Plasma cell leukemia (PCL) is a rare and aggressive plasma cell disorder, with poor outcome. Bortezomib-based regimens (BBR) are highly effective in myeloma, but there is limited information about their efficacy and safety in PCL. Thus, we retrospectively collected data from 42 consecutive PCL patients (25 with primary PCL-pPCL and 17 with secondary PCL-sPCL) to explore the role of BBR in this entity. BBR were administered in 29 of 42 patients, while 6 of 25 patients with pPCL underwent autologous transplantation. Objective response (≥partial response) was significantly higher in patients treated with BBR versus conventional therapies (69% vs. 30.8%, P = 0.04); 27.5% of patients treated with BBR achieved at least very good partial response (vgPR). The highest ORR was observed in pPCL patients treated with BBR (88.9%; ≥vgPR: 33.3%). In BBR-group, grade 3 of 4 hematological, neurological and renal toxicity and neutropenic infections were observed in 41.4%, 7%, 3.4%, and 31%, respectively. With a median follow-up of 51 months, median overall survival (OS) for patients treated with BBR versus conventional therapies was 13 versus 2 months (P < 0.007). Median OS of patients with pPCL and sPCL treated with BBR was 18 and 7 months, respectively (P < 0.001). In the multivariate analysis normal PLTs, treatment with BBR and high quality response were the only powerful predictors for survival. Our study carrying the longest reported median follow-up, demonstrated that treatment of PCL with BBR induces high response rates and prolongs survival over conventional therapies, regardless of additional autologous transplantation rescue or established high risk features, with manageable toxicity.
Abstract 12997: Reduced Exercise Capacity Attributable to Latent Left Ventricular Diastolic Dysfunction Unmasked by Invasive Exercise Testing in Diabetic Patients After Acute Myocardial Infarction
Authors: Michinari Hieda, Shinji Yasuno, Noritoshi Nagaya, Hiroshi Takaki, Yoichi Goto
Journal: Circulation (2014)

Introduction: Left ventricular (LV) diastolic dysfunction has been reported to be associated with reduced exercise capacity in patients with diabetes mellitus (DM). However, the relation between ex...
A memorable patient: Never fully examined
Authors: K P Paulose
Journal: BMJ (1998)

In 1989, when I was head of the department of medicine in Kerala, a 40 year old unmarried woman, a ward attender in the same hospital, was admitted with mid back pain of three months' duration. A chest x ray examination was normal, but an x ray examination of the spine showed collapse of the T10 vertebra with narrowing of intervertebral space. A Mantoux test was positive. In view of the absence of any detectable primary lesion, the possibility of tuberculosis of the spine was suspected. The patient was subsequently referred to the orthopaedic surgeon who also agreed with the diagnosis and advised antituberculous …
Abstract 16134: Impact of Perioperative Management on Prevention of Prosthetic Valve Detachment After Aortic Valve Replacement for Patient With Takayasu’s Arteritis
Authors: Shunsuke Sato, Kenji Minatoya, Tomoyuki Fujita, Tatsuya Oda, Yoshimasa Seike, Tatsuya Itonaga, Yusuke Shimahara, Hiroki Hata, Hiroaki Sasaki, Hatsue Ishibashi-Ueda, Junjiro Kobayashi
Journal: Circulation (2014)

Background: Patients with Takayasu’s arteritis sometimes complain of aortic regurgitation. We investigate the impact of perioperative management on prevention of prosthetic valve detachment after aortic valve replacement for patient with Takayasu’s arteritis.

Methods: Eighty-six Takayasu’s arteritis patients who underwent aortic valve replacement were enrolled in this study. Thirty-eight patients (44.2%) were administered steroid preoperatively. Preoperative steroid dose was 1-9mg of prednisolone per day in 9 patients (10.5%), 10-19mg/day in 21 (24.4%), and 20-30mg/day in 8 (9.3%). Follow-up period was 12.1+-8.1 years.

Results: Forty-four patients (51.8%) had active inflammation of the aortic valve. Survival rate was 77.1% at 10 years and 56.6% at 20 years. Prosthetic valve detachment free rate was 80.8% at 10 years and 71.1% at 20 years.

In multivariate study, active inflammation, young age and high CRP at 30 days after operation were risk factors for valve detachment (Table).

Conclusion: Inflammation is related to prosthetic valve detachment after aortic valve replacement for patient with Takayasu’s arteritis. Perioperative aggressive inflammation control using steroid is important to prevention of detachment.

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Sampling circulating tumor cells for clinical benefits: how frequent?
Authors: Sai Mun Leong, Karen M L Tan, Hui Wen Chua, Doreen Tan, Delly Fareda, Saabry Osmany, Mo-Huang Li, Steven Tucker, Evelyn S C Koay
Journal: Journal of Hematology & Oncology (2015)

Circulating tumor cells (CTCs) are cells shed from tumors or metastatic sites and are a potential biomarker for cancer diagnosis, management, and prognostication. The majority of current studies use single or infrequent CTC sampling points. This strategy assumes that changes in CTC number, as well as phenotypic and molecular characteristics, are gradual with time. In reality, little is known today about the actual kinetics of CTC dissemination and phenotypic and molecular changes in the blood of cancer patients. Herein, we show, using clinical case studies and hypothetical simulation models, how sub-optimal CTC sampling may result in misleading observations with clinical consequences, by missing out on significant CTC spikes that occur in between sampling times. Initial studies using highly frequent CTC sampling are necessary to understand the dynamics of CTC dissemination and phenotypic and molecular changes in the blood of cancer patients. Such an improved understanding will enable an optimal, study-specific sampling frequency to be assigned to individual research studies and clinical trials and better inform practical clinical decisions on cancer management strategies for patient benefits.
PLACEBO-CONTROLLED STUDY OF MYCOPHENOLATE MOFETIL COMBINED WITH CYCLOSPORINE AND CORTICOSTEROIDS FOR PREVENTION OF ACUTE REJECTION
Authors: J Grinyo, C Groth, R Pichlmayr, Sa Sadek, Y Vanrenterghem, M Behrend, R Luck, F Moreso, J Peeters, J Rodicio, J Morales, D Albrechtsen, P Fauchald, S Sadek, J Lodge, Jp Soulillou, D Cantarovich, van Willem Son, Adam Tegzess, K Wagner, J Erhard, C Brattstrom, L Mjornstedt, M Wiesel, S Carl, Hh Neumayer, Hauser, P Lang, B Bourgeon, G Tufveson, G Gannedahl, H Ekberg, N Persson, A Tarantino, M Campise, G Thiel, M Zeiler, R Hene, G Ligtenberg, A Morgan, K Rigg, L Hooftman, K Hutchinson
Journal: The Lancet (1995)
Microbes Which Help or Destroy Us
Authors: P. B. Cowles
Journal: JAMA (1941)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Familial Benign Hypercalcemia (Hypocalciuric Hypercalcemia)
Authors: WILLIAM M LAW
Journal: Annals of Internal Medicine (1985)

Familial benign hypercalcemia (hypocalciuric hypercalcemia) was diagnosed in 125 members of 21 families. The syndrome was generally characterized by autosomal dominant inheritance of symptomless, nonprogressive hypercalcemia with normal serum immunoreactive parathyroid hormone concentrations, parathyroid glands that had normal gross and histologic features, relatively low urinary excretion of calcium, and failure to achieve normocalcemia after subtotal parathyroidectomy. Affected persons had normal longevity and no discernible increase in other medical problems except gallstones. The parathyroid glands were not seen using high-resolution ultrasonography. Plasma calcitonin and calcitriol levels were normal or low. Skeletal mass was normal as assessed by photon absorptiometry of the radius and lumbar spine, and fractures were not more frequent. Familial benign hypercalcemia or hypocalciuric hypercalcemia is a distinctive heritable syndrome that should always be considered in the differential diagnosis of asymptomatic hypercalcemia.
Surgeons pleased with patient's progress after face transplant
Authors: Brad Spurgeon
Journal: BMJ (2005)

Less than a week after French doctors carried out the world's first partial face transplant on 27 November, the patient—a 38 year old woman—ate, drank, and spoke normally. Professor Jean-Michel Dubernard, who led the transplant team, said that it would be at least six months before they knew how much feeling or motor control the patient would have eventually.

Doctors have been technically ready to do such surgery for some time but have held back for ethical reasons. Carine Camby, the director general of the agency of biomedicine, part of the …
Decoding Parasite Genomes
Authors: Joan Stephenson
Journal: JAMA (2005)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal