tbuckley/cabot-search huggingface dataset:
Serum Creatine Kinase as a Test of Thyroid Function
Authors: WILLIAM M. MCCONAHEY
Journal: Annals of Internal Medicine (1969)

Editorial Notes1 November 1969Serum Creatine Kinase as a Test of Thyroid FunctionWILLIAM M. MCCONAHEY, M.D.WILLIAM M. MCCONAHEY, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-71-5-1022 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptIn a recent French paper, Itelson, Rubinstein, Gaist, and Ménaché (1) reemphasize the previously reported information (2-4) that creatine kinase activity in serum is above normal in patients who have hypothyroidism and below normal in those who have hyperthyroidism. On the basis of these findings they advocate the measurement of serum creatine kinase as a diagnostic "screening test" of thyroid function. The diagnostic potential of this test appears to be greater in hypothyroidism than in hyerpthyroidism because the mean level in the former is about eight times the normal mean but in the latter only about one half the normal...References1. ITELSONRUBINSTEINGAISTMÉNACHÉ JJLR: La place des variations de l'activité de la créatine kinase sérique parmi les tests de la fonction thyroïdienne. Rev. Franc. Étud. Clin. Biol. 13: 905, 1968. MedlineGoogle Scholar2. GRAIGROSS FAG: Serum creatine-phosphokinase in thyroid disease. Metabolism 12: 57, 1963. MedlineGoogle Scholar3. GRIFFITHS PD: Creatinephosphokinase levels in hypothyroidism (Letter to the editor). Lancet 1: 894, 1963. CrossrefMedlineGoogle Scholar4. FLEISHERMCCONAHEYPANKOW GAWMM: Serum creatine kinase, lactic dehydrogenase, and glutamic-oxalacetic transaminase in thyroid diseases and pregnancy. Mayo. Clin. Proc. 40: 300, 1965. MedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Mayo Graduate School of Medicine University of Minnesota Rochester, Minn. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byCreatine KinaseThe relationship between serum creatine kinase and thyroid hormones: In vivo and in vitro studiesIncreased plasma creatine kinase activity in rabbits: Effect of systematically repeated blood sampling 1 November 1969Volume 71, Issue 5_Part_1Page: 1022-1023KeywordsCreatine kinaseHyperthyroidismHypothyroidismThyroid Issue Published: 1 November 1969 PDF downloadLoading ...
PREVENTABLE BLINDNESS—A CHALLENGE TO THE PROFESSIONS
Authors: HENRY COPLEY GREENE
Journal: JAMA (1913)

the presence of direct pupillary reaction when the cen- tral scotoma is greater than the pupillomotor area as tested by large disks requires further tests for lightperception as described.4. Observations may be complicated by "concentric movement" or other'psychic reactions which may some- times be eliminated by repetition.5. Clinically the hemiopic pupillary reaction, in those chiasmal lesions of dyspituitary origin, of rather rapid onset and rapid recovery after operation, has failed, possibly due to a certain retention of pupillomotoric function, centrally, after vision for disks has been lost by the hemiopic retina.II.THE WILBRAND HEMIANOPTIO PRISM PHENOMENON 1.The peculiar distribution of field defects in anterior and posterior lesions often adds to and encourages psychologic factors which greatly complicate the Wil- brand test.2. The presence of pseudorefixation, as demon- strated by the new method described, throws serious doubts on the presence of a definite reflex arc in the Wilbrand prism-phenomenon.',].Clinically, the Wilbrand test has offered no valu- able diagnostic data in these cases.All the cases mentioned in the paper were examined in the large neurologie surgical clinic of Dr. Harvey Gushing, to whose kindness and generosity I am deeply indebted for the privilege of presenting this particular phase of these cases, I extend my sincere thanks to Dr. Gushing for stimulating interest in this work, to Dr. George S. Derby,
The If and When of Surgical Debulking for Ovarian Carcinoma
Authors: Tate Thigpen
Journal: New England Journal of Medicine (2004)

Celomic epithelial carcinoma of the ovary, in contrast to most other gynecologic cancers, often causes no symptoms in its early stages and is usually diagnosed only after it has spread to other parts of the peritoneal cavity or to more distant sites. As a result, curative surgical resection is not an option for most patients. Moreover, ovarian carcinoma, unlike most other solid tumors, typically spreads by seeding throughout the peritoneal cavity. For these reasons, the disease is most commonly diagnosed at stage III, in which the process is grossly confined to the peritoneal cavity. Such cases are not amenable to . . .
Endoscopic Management of Dieulafoy Lesions of the Stomach: A Case Study of 26 Patients.
Authors: A. Parra-Blanco, H. Takahashi, P.V. Méndez Jerez, T. Kojima, K. Aksoz, K. Kirihara, J. Palmerín, Y. Takekuma, R. Fuijta
Journal: Endoscopy (1997)

We studied the clinical features and therapeutic outcome in patients with a diagnosis of Dieulafoy lesion.Twenty-six patients who had upper gastrointestinal bleeding from Dieulafoy lesions received endoscopic therapy. The clinical and endoscopic features, and the outcome of therapy, were analysed retrospectively.Hemostasis was attempted by hemoclipping in 18 patients, heater probe in six patients and ethanol injection in two patients. The initial therapy was successful in 22 (84.6%) cases. Hemostasis was achieved with additional endoscopic therapy in three cases (11,5%). Surgical treatment was needed only in one case, owing to uncontrolled bleeding. One patient died during the hospital stay from a cause unrelated to the Dieulafoy lesion. There were no side effects related to endoscopic therapy. None of these patients presented with rebleeding from Dieulafoy lesions over a mean long-term follow-up of 36 months.Bleeding from Dieulafoy lesions can be managed successfully by endoscopic methods, and these should be regarded as the first choice in their management. We emphasize the role of hemoclipping, a mechanical method, for the endoscopic treatment of these lesions.
Predictors of Outcome in Chronic Thromboembolic Pulmonary Hypertension
Authors: Diana Bonderman, Nika Skoro-Sajer, Johannes Jakowitsch, Christopher Adlbrecht, Daniela Dunkler, Sharokh Taghavi, Walter Klepetko, Meinhard Kneussl, Irene M. Lang
Journal: Circulation (2007)

Chronic thromboembolic pulmonary hypertension (CTEPH) is characterized by intraluminal thrombus organization and fibrous obliteration of pulmonary arteries. Recently, associated medical conditions such as splenectomy, ventriculoatrial shunt for the treatment of hydrocephalus, permanent central intravenous lines, inflammatory bowel disease, and osteomyelitis were found to be associated with the development of CTEPH. The study aim was to define the impact of these novel risk factors on survival.Between January 1992 and December 2006, 181 patients diagnosed with CTEPH were tracked with the use of our center's customized computer database. A Cox regression model was used to examine relations between survival and associated medical conditions, age, sex, hemodynamic parameters, modified New York Heart Association functional class at diagnosis, CTEPH type, pulmonary endarterectomy, and anti-cardiolipin antibodies/lupus anticoagulant. During a median observation time of 22.1 (range, 0.03 to 152) months, the clinical end point of cardiovascular death or lung transplantation occurred in 48 cases (27%). Pulmonary endarterectomy (hazard ratio, 0.14; 95% CI, 0.05 to 0.41; P=0.0003), associated medical conditions (hazard ratio, 3.17; 95% CI, 1.70 to 5.92; P=0.0003), and pulmonary vascular resistance (hazard ratio, 1.02; 95% CI, 1.00 to 1.04; P=0.04) were predictors of survival. Thirty-day postoperative mortality (24% versus 9%) and the incidence of postoperative pulmonary hypertension (92% versus 20%) were substantially higher in patients with associated medical conditions.CTEPH-predisposing medical conditions, such as splenectomy, permanent central intravenous lines, and certain inflammatory disorders, predict poor survival in CTEPH.
Control of rat renal vascular resistance at reduced perfusion pressure.
Authors: P A Johnston, N S Perrin, D B Bernard, N G Levinsky
Journal: Circulation Research (1981)

Determination of the factors influencing renal vascular resistance (RVR) at very low perfusion pressures (RPP) is of interest, since prolonged periods of reduced perfusion can lead to acute renal failure.We have studied the effects of inhibition of the renin-angiotensin system on renal blood flow (RBF), measured by electromagnetic flow probe, over a subautoregulatory pressure range of BO-SS mm Hg.These studies were carried out in rats on low sodium diets (LS), in which angiotensin II (All) is increased, and high sodium diets (HS), in which All is suppressed.We have also studied the effect of altering the kallikrein-kinin system, since our previous studies have indicated an interaction between this system and All in control of RVR at normal RPP.Variations in sodium intake did not alter the regression of RBF on RPP over the entire low pressure range.. RVR in LS rats increased from 15.8 ± 0.4 between 65 and 90 mm Hg to 21.2 ± 1.2 mm Hg/ml per min at pressures <45 mm Hg (P < 0.05).In HS rats, RVR rose from 13.8 ± 0.5 at RPP between 65 and 90 mm Hg to 18.6 ± 0.9 mm Hg/ml per min at RPP < 45 mm Hg (P < 0.001).Saralasin, an All antagonist, increased RBF, and thus reduced RVR, over the entire low pressure range in LS rats, but had no effect on RVR in HS rats.Captopril, which inhibits the formation of All as well as the degradation kinins, increases RBF in both LS and HS rats.Aprotinin, an inhibitor of kallikrein, reduced RBF, and thus increased RVR over the entire low pressure range in LS rats.Aprotinin had no effect on RVR in HS rats, but pretreatment with this agent blocked the vasodilatory effect of captopril.Infusion of kinins raised RBF in HS rats but had no effect on RBF of LS rats.We conclude that RVR is not fixed or minimal in the subautoregulatory pressure range.AH acts as a vasoconstrictor throughout this low pressure range in LS rats, but its effect is countered by the vasodilator influence of kinins.Neither hormone substantially influenced RVR in HS rats.Parallel changes in the activity of these two hormones maintains a relatively constant RVR despite changes in dietary sodium intake.
The influence of waist circumference on insulin resistance and nonalcoholic fatty liver disease in apparently healthy Korean adults
Authors: Deok Yun Ju, Young Gil Choe, Yong Kyun Cho, Dong Suk Shin, Su Hyeon Yoo, Seo Hyoung Yim, Ji Yong Lee, Jung Ho Park, Hong Joo Kim, Dong Il Park, Chong Il Sohn, Woo Kyu Jeon, Byung Ik Kim
Journal: Clinical and Molecular Hepatology (2013)

Background/Aims Waist circumference (WC) is a risk factor for metabolic syndrome and is related to insulin resistance (IR) and nonalcoholic fatty liver disease (NAFLD). The purpose of this study was to determine the association between WC and IR and NAFLD in apparently healthy Korean adults. Methods The volunteers included in this cross-sectional study comprised 9,159 adults (5,052 men, 4,107 women) who participated in a comprehensive health checkup program. IR was evaluated by the homeostasis model assessment of IR (HOMA-IR) and was considered to be present when the HOMA-IR score was >2. NAFLD was evaluated by ultrasound examination. Elevated alanine aminotransferase (ALT) was defined as >40 IU/L in men and >35 IU/L in women. Logistic regression was performed to determine the odds ratios (ORs) and 95% confidence intervals (95% CIs) for NAFLD, IR, and ALT according to categorized levels of WC. Results NAFLD was found in 2,553 (27.9%) of the participants (82.6% men, 17.4% women), while IR and elevated ALT were found in 17.2% (68.1% men, 31.9% women) and 10% (83% men, 17% women), respectively. After adjusting for confounding factors, the prevalence of NAFLD, IR, and elevated ALT was significantly associated with increases in WC quartile: highest quartile for NAFLD in men, OR=15.539, 95% CI=12.687-19.033; highest quartile for NAFLD in women, OR=48.732, 95% CI=23.918-99.288 (P<0.001); and highest quartile for IR in men, OR=17.576, 95% CI=13.283-23.255; highest quartile for IR in women, OR=11.078, 95% CI=7.813-15.708 (P<0.001); highest quartile for elevated ALT in men, OR=7.952, 95% CI=6.046-10.459; and highest quartile for elevated ALT in women, OR=8.487, 95% CI=4.679-15.395 (P<0.001). Conclusions WC contributes to IR and NAFLD in apparently healthy Korean adults, and thus may be an important factor in the development of IR and NAFLD. Keywords: Waist circumference; Insulin resistance; Nonalcoholic fatty liver disease
The Landry-Guillain-Barré-Strohl Syndrome
Authors: Felix Leneman
Journal: JAMA (1966)

<h3>To the Editor:—</h3> I agree with Dr. Poser that the Landry-Guillain-Barré-Strohl syndrome should not be considered a<i>primary</i>demyelinating disease, as the last sentence of the editorial seems to imply; however, I wonder what causes demyelination, if any, in those numerous cases which seem to occur entirely de novo.
Men should eat nine servings of fruit and vegetables a day
Authors: S. Gottlieb
Journal: BMJ (2003)

The US National Cancer Institute is launching a publicity campaign to boost men's fruit and vegetable consumption to nine servings a day. Although past campaigns have touted the need for five servings a day, health experts now say five is just the bare minimum.

Although men are the focus of the new campaign, health officials note that women should increase their consumption to seven servings a day and children should eat at least five. The institute, which for more than a decade has spearheaded the “Eat 5 a Day” publicity campaign, has changed its logo to the …
Italy's smoking ban has led to an 8% drop in tobacco consumption
Authors: Roger Dobson
Journal: BMJ (2005)

The restriction of smoking in public places in Italy has led to an 8% drop in cigarette consumption, a new study says.

And the ban on smoking in indoor public places has been almost universally accepted and does not seem to have had an adverse effect on business, say the authors of the study, which was published online ahead of print publication …
The International Occurrence of the Acquired Immunodeficiency Syndrome
Authors: J. B. BRUNET
Journal: Annals of Internal Medicine (1985)

Through December 1984, 9932 cases of the acquired immunodeficiency syndrome have been reported, mainly from North and South America and Europe; 85% of these cases occurred in the United States. Haiti and the United States have the highest incidence rates, 59 and 36 per million population, respectively. Rates in the United States range from 0.3 (beginning of 1981) to 10.4 (end of 1984). Brazil, Canada, Denmark, Switzerland, France, West Germany, the United Kingdom, and the Netherlands show a slower increase. Homosexual men and intravenous drug users are still the main risk groups in the United States and Europe. The disease is prevalent in heterosexual Haitians and Africans whether they live in their own countries or abroad. Cases of the syndrome have been identified in Zaire, Rwanda, Zambia, and Uganda, but its full extent is not yet known. Consistent with the general history of epidemics, the appearance of geographically separated sites of incidence of the syndrome could be linked to population migrations; however no evidence has been found to identify an index location.
Impact of Smoking on Cancer Stage at Diagnosis
Authors: Nathan L. Kobrinsky, Marilyn G. Klug, Peggy Jo Hokanson, Diane E. Sjolander, Larry Burd
Journal: Journal of Clinical Oncology (2003)

Studies evaluating the relationship between smoking and cancer spread are limited.We studied the relationship between cancer stage at diagnosis (local, regional, or metastatic) and smoking history (current, previous, or nonsmoker). For lung cancer, patterns of spread were also studied.In a tumor registry for eastern North Dakota, northwestern Minnesota, and northern South Dakota, 11,716 cases were identified from 1986 to 2001. Current smokers (relative risk [RR], 2.11; 95% confidence interval, 1.93 to 2.32; P <.001) and previous smokers (RR, 1.56; 95% confidence interval, 1.42 to 1.72; P <.001) had an increased risk of metastatic disease at diagnosis. Current smokers (RR, 1.39; 95% confidence interval, 1.29 to 1.51; P <.001), but not previous smokers, also had an increased risk of regional disease. An increase in metastatic disease was most evident for prostate cancer (RR, 1.53; P =.003). An increase in regional disease was most evident for head and neck (RR, 3.53; P <.001), prostate (RR, 1.83; P =.030), and breast cancer (RR, 1.22; P =.005). Compared with previous smokers, current smokers with metastatic lung cancer were more likely to have involvement of the brain (33.6% v 23.0%; P =.004), bone marrow, adrenal gland, and pericardium (24.7% v 15.9%; P =.004).Previous or current smoking is a risk factor for increased cancer stage in a wide range of malignancies. Further study is required to determine whether this association is causal.
Spontaneous diastolic contractions and phosphorylation of the cardiac ryanodine receptor at serine-2808 in congestive heart failure in rat
Authors: M OBAYASHI, B XIAO, B STUYVERS, A DAVIDOFF, J MEI, S CHEN, H TERKEURS
Journal: Cardiovascular Research (2005)

Journal Article Spontaneous diastolic contractions and phosphorylation of the cardiac ryanodine receptor at serine-2808 in congestive heart failure in rat Get access Masakazu Obayashi, Masakazu Obayashi aDepartment of Medical Bio-regulation, Division of Cardiovascular Medicine, Yamaguchi University School of Medicine, Ube, Yamaguchi, Japan Search for other works by this author on: Oxford Academic PubMed Google Scholar Bailong Xiao, Bailong Xiao bDepartments of Medicine, Physiology and Biophysics, Health Sciences Center, University of Calgary, Calgary, Alberta, Canada Search for other works by this author on: Oxford Academic PubMed Google Scholar Bruno D. Stuyvers, Bruno D. Stuyvers bDepartments of Medicine, Physiology and Biophysics, Health Sciences Center, University of Calgary, Calgary, Alberta, Canada Search for other works by this author on: Oxford Academic PubMed Google Scholar Allen W. Davidoff, Allen W. Davidoff bDepartments of Medicine, Physiology and Biophysics, Health Sciences Center, University of Calgary, Calgary, Alberta, Canada Search for other works by this author on: Oxford Academic PubMed Google Scholar Jie Mei, Jie Mei bDepartments of Medicine, Physiology and Biophysics, Health Sciences Center, University of Calgary, Calgary, Alberta, Canada Search for other works by this author on: Oxford Academic PubMed Google Scholar S.R. Wayne Chen, S.R. Wayne Chen bDepartments of Medicine, Physiology and Biophysics, Health Sciences Center, University of Calgary, Calgary, Alberta, Canada Search for other works by this author on: Oxford Academic PubMed Google Scholar Henk E.D.J. ter Keurs Henk E.D.J. ter Keurs * bDepartments of Medicine, Physiology and Biophysics, Health Sciences Center, University of Calgary, Calgary, Alberta, Canada *Corresponding author. Department of Physiology/Biophysics, University of Calgary, 3330 Hospital Drive, NW, Calgary, Alberta, Canada, T2N 4N1. Tel.: +1 403 289 7156; fax: +1 403 270 0313. Email address: [email protected] Search for other works by this author on: Oxford Academic PubMed Google Scholar Cardiovascular Research, Volume 69, Issue 1, January 2006, Pages 140–151, https://doi.org/10.1016/j.cardiores.2005.07.010 Published: 01 January 2006 Article history Received: 18 February 2005 Revision received: 07 July 2005 Accepted: 11 July 2005 Published: 01 January 2006
Access to scrotal ultrasonography
Authors: R D Pocock, M A Stott, M C Crundwell, A Watkinson, R Thomas, J Coote, J Harington
Journal: Journal of the Royal Society of Medicine (2004)

I wonder whether Barbara Gomes and Irene Higginson, who wrote the excellent editorial on place of death (September 2004 JRSM 1 ), would consider that a poll of RSM Fellows might provide useful data?I have seen only two formal papers, both from the USA, regarding the medical technology health workers would want for themselves at the end of life.One disclosed that the great majority of doctors in North Carolina would refuse cardiopulmonary resuscitation and tube feeding if terminally ill. 2 The other concluded that physicians and nurses who have extensive exposure to hospitals and sick patients are unlikely to wish aggressive treatment if they become terminally ill, demented, or in a persistent vegetative state. 3 I suspect that most British health professionals would be similarly reluctant to have much medical technology applied to them at the end of life, and, by what seems an obvious extension, would rather die at home than in hospital.Personally, if I do not die suddenly, I want to die at home, in very familiar surroundings, with my beloved cat and partner next to me, and with the music of Shirley Bassey as loud as possible.
Higher professional training in general practice: provision of master's degree courses in the United Kingdom in 1993
Authors: L F P Smith
Journal: BMJ (1994)

Review of a 1993 survey of the 29 United Kingdom departments of general practice (or equivalent) identified seven master's degree courses available for general practitioners. Up to another 11 are planned within the next five years. Around 50 general practitioners undertake all such courses at any one time. Possible reasons for this low uptake include cost, lack of flexibility of courses, and the prospect of writing a thesis. Appropriate master's courses are essential to the future development of general practice, and this paper postulates the characteristics of an "ideal" course.
The Final Epidemic: Nuclear and Population Explosions
Authors: Norman Ende
Journal: JAMA (1985)

<h3>To the Editor.—</h3> Much of the Aug 3, 1984, issue ofThe Journaldevoted itself to the horrors of nuclear war; throughout the issue was the constant implication that implementation of nuclear freeze is mandatory in the light of potential conflict between the United States and the Soviet Union. Early in July 1984, the World Bank reported the imminent population explosion facing a significant portion of the world between now and the year 2150. Despite the fact that the dire contents of the World Bank Report had been anticipated for well over half a decade and much discussion has been offered in many public forums over what can be done both to reduce this population increase and to feed those who are a product of it, none of the contributing authors of the Aug 3 issue gave consideration to the potential threat of our own nuclear annihilation inherent in such