tbuckley/cabot-search huggingface dataset:
Skin cancer incidence and the ageing population
Authors: B.L. Diffey, J.A.A. Langtry
Journal: British Journal of Dermatology (2005)

Journal Article Skin cancer incidence and the ageing population Get access B.L. Diffey, B.L. Diffey Regional Medical Physics Department, Newcastle General Hospital, Newcastle upon Tyne NE4 6BE, U.K. Department of Dermatology, Sunderland Royal Hospital, Sunderland SR4 7TP, U.K. E‐mail: b.l.diffey@ncl.ac.uk Search for other works by this author on: Oxford Academic Google Scholar J.A.A. Langtry J.A.A. Langtry Regional Medical Physics Department, Newcastle General Hospital, Newcastle upon Tyne NE4 6BE, U.K. Department of Dermatology, Sunderland Royal Hospital, Sunderland SR4 7TP, U.K. E‐mail: b.l.diffey@ncl.ac.uk Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 153, Issue 3, 1 September 2005, Pages 679–680, https://doi.org/10.1111/j.1365-2133.2005.06799.x Published: 01 September 2005
Angiotensin II Plays a Critical Role in Alcohol-Induced Cardiac Nitrative Damage, Cell Death, Remodeling, and Cardiomyopathy in a Protein Kinase C/Nicotinamide Adenine Dinucleotide Phosphate Oxidase–Dependent Manner
Authors: Yi Tan, Xiaokun Li, Sumanth D. Prabhu, Kenneth R. Brittian, Qiang Chen, Xia Yin, Craig J. McClain, Zhanxiang Zhou, Lu Cai
Journal: Journal of the American College of Cardiology (2012)
Manufacture and use of home made ophthalmoscopes: a 150th anniversary tribute to Helmholtz Commentary: "Here's one I prepared earlier"
Authors: R. H Armour, N. F Hall
Journal: BMJ (2000)

<h3>Abstract</h3> <b>Objective:</b> To produce a simple, effective, and inexpensive training ophthalmoscope. <b>Design:</b> Case study. <b>Setting:</b> A coffee table in a sitting room and an eye clinic. <b>Participants:</b> 10 friends and relatives, several patients, and a cooperative Persian cat. <b>Interventions:</b> Direct ophthalmoscopy with instrument made with easily available material and tools from art and office equipment shops. <b>Main outcome measures:</b> Efficiency, clarity of view, and price of ophthalmoscope. <b>Results:</b> The instrument was readily made; of the 50 manufactured two thirds gave a good view; and each cost less than £1 to make. <b>Conclusion:</b> The ophthalmoscope is fun to make, works well, and anyone can make one.
NICOTINIC ACID IN THE TREATMENT OF DEPRESSION
Authors: W L TONGE
Journal: Annals of Internal Medicine (1953)

Article1 March 1953NICOTINIC ACID IN THE TREATMENT OF DEPRESSIONW. L. TONGE, M.B. (Manc.) D.P.M. (Lond.)W. L. TONGE, M.B. (Manc.) D.P.M. (Lond.)Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-38-3-551 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptA preliminary report1 on the treatment with nicotinic acid of 15 patients suffering from various forms of depression shows 14 much improved. This result is of sufficient interest to merit further investigation. The rationale of the procedure lies in the possible association between abnormal mental states and disturbances of cerebral circulation, and it was suggested that measures which lead to vasodilatation also bring about an improvement in the mental state.The present series, treated at the Manchester Royal Infirmary, is of 16 patients who were consecutive referrals to the University Clinic, November, 1950, to July, 1951. It included five cases...Bibliography1. Washburne AC: Nicotinic acid in the treatment of certain depressed states: a preliminary report, Ann. Int. Med. 32: 261, 1950. LinkGoogle Scholar2. HimwichCameronHomburgerFeldman HEDEEF: Cerebral metabolism in patients with depression, Am. J. Psychiat. 101: 453, 1945. CrossrefGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Manchester,*Received for publication July 12, 1952.From the Department of Psychiatry of the University of Manchester, England. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byMixtures modeling identifies vitamin B1 and B3 intakes associated with depressionRapid action of mechanism investigation of Yixin Ningshen tablet in treating depression by combinatorial use of systems biology and bioinformatics toolsPharmacologic Use of NiacinNeuropsychiatric consequences of cardiovascular medicationsTHE USE OF VITAMIN THERAPY TO REVERSE CERTAIN CONCOMITANTS OF AGING† 1 March 1953Volume 38, Issue 3Page: 551-553KeywordsNiacinVasodilation ePublished: 1 December 2008 Issue Published: 1 March 1953 PDF downloadLoading ...
Asymptomatic carriage of Neisseria meningitidis in a randomly sampled population. Serogroup, serotype and subtype distribution and associated risk factors
Authors: Dionisia Fontanals, Diego Van Esso, Immaculada Pons, Valenti Pineda, Isabel Sanfeliu, Dolors Mariscal, Julio Alberto Vázquez, Pere Coll, Guillem Prats
Journal: Clinical Microbiology and Infection (1996)
Decreased Incidences of Resistance to Antimicrobial Agents Among<i>Escherichia coli</i>and<i>Klebsiella-Enterobacter</i>
Authors: ROGER J. BULGER
Journal: Annals of Internal Medicine (1970)

Antibiograms were reviewed of all strains of Escherichia coli and Klebsiella-Enterobacter isolated from lesions of patients at the University of Washington Hospital, Seattle, from mid-1959 through 1968. No trend to increasing resistance to any of the chemotherapeutics tested was noted among the isolates of E. coli or Klebsiella-Enterobacter, and declining resistance was evident. E. coli showed an increase of strains resistant to none or only one of the seven agents and a decrease in multiply resistant strains. The frequency of E. coli bacteremia has not increased since 1959-1960 and 1961, and the antibiograms of organisms isolated from the blood generally coincided with the antibiograms of the total population. The incidences of Klebsiella-Enterobacter strains resistant to the seven chemotherapeutic agents also diminished as did that of multiply resistant strains. In contrast to E. coli, the frequency of klebsiella-enterobacter bacteremia did not diminish during the first 7 years; during the subsequent 3 years there was a marked decrease in frequency of positive blood cultures. The incidences of resistance to tetracycline and streptomycin may be associated with the amounts used per patient.
Abstract 11040: Not Carotid but Femoral Artery Intima-Media Thickness Predicts Peripheral Artery Disease in Patients With Coronary Artery Disease
Authors: Naoki Okumura, Makoto Saito, Toshiro Tanaka, Masaya Matsumoto, Masami Tsuzuki, Toyoaki Murohara
Journal: Circulation (2014)

Background: Numerous studies reported the clinical and prognostic significance of carotid artery intima-media thickness (IMT) in atherosclerotic disease patients. However, clinical significance of femoral artery IMT was not fully elucidated. Femoral artery IMT may have unique clinical significance in patients with coronary artery disease (CAD). Purpose: We examined the relationship among carotid and femoral artery IMT, the presence of PAD, and risk factors in fully medically treated patients with CAD. Methods: Patients (n = 192; mean age 71.8±10.4 years) who were diagnosed by coronary angiography were enrolled. PAD was defined as ABI < 0.9. Using ultrasound echo, the mean common carotid and femoral artery IMT were evaluated. We evaluated the diagnostic value of the carotid and femoral artery IMT for PAD. To determine the cutoff value of IMT for prediction of PAD, we used a receiver operating characteristic (ROC) analysis. Furthermore, we examined the differences of risk factors for the increased IMT in bo...
The Induction of Melanotic Tumors Resembling Cellular Blue Nevi in the Syrian White Hamster by Cutaneous Application of 7,12-Dimethylbenz[a]anthracene
Authors: Henry Rappaport, Giuseppe Pietra, Philippe Shubik
Journal: Cancer Research (1961)

Melanotic tumors resembling cellular blue nevi of man were induced in the Syrian white hamster by single and multiple applications of 7,12-dimethylbenz[ a ]anthracene (DMBA). Histologically they resembled the melanotic tumors produced under similar experimental conditions in the Syrian golden hamster. They showed great variations in pigment content from almost nonpigmented to heavily pigmented tumors. Study of early lesions suggested origin of the melanotic tumors in the Syrian white hamster from amelanotic perifollicular melanocytes. None of the induced tumors metastasized. One of the poorly pigmented tumors was transplanted into both golden and white Syrian hamsters. One of the transplants gave rise to metastases to lymph nodes, lungs, and kidneys. The capacity to produce pigment was retained in the transplanted tumors. The study confirms our previous observation that cutaneous application of a single dose of DMBA to Syrian hamsters induces a high incidence of melanotic tumors which differ morphologically and biologically from the melanomas known to occur spontaneously in the Syrian golden hamster.
Hematology: Basic Principles and Practice
Authors: Ronald Hoffman
Journal: Annals of Internal Medicine (1991)

Part I: Mollecular and Cellular Basis of Hematology. Anatomy and Physiology of the Gene. Protein Synthesis and Intracellular Sorting. Protein Architecture: Relationship of Form and Function. Membrane Biology. Cell Adhesion. Cellular Regulatory and Control Mechanism. Part II: Immunologic Basis of Hematology. Overview of the Immune System (including Compartmentalization of the Immune Response). Generation of B-cells. T-cell Immunity. Regulation of Activation of B and T-cells. Tolerance and Autoimmunity. Part III: Biology of Stem Cells and Disorders of Hematopoiesis. Stem Cell Model of Hematopoiesis. Anatomy and Physiology of Hematopoiesis. Growth Factors and the Control of Hematopoiesis. Biology of Erythropoiesis, Erythroid Differentiation and Maturation. Granulopoiesis and Monocytopoiesis. Thrombocytopoiesis. Inherited Forms of Bone Marrow Failure. Aplastic Anemia. Paroxysmal Nocturnal Hemoglobinuria. Pure Red Blood Cell Aplasia. Part IV: Red Blood Cells. Pathobiology of the Red Cell. Approach to the Adult and Child with Anemia. Anemia of Chronic Diseases. Erythrocytosis. Disorders of Iron Metabolism: Iron Deficiency and Overload. Heme Biosynthesis and Its Disorders: Porphyrias and Sideroblastic Anemias. Megaloblastic Anemias. Thalassemia Syndromes. Sickle Cell Disease. Hemoglobin Variants Associated with Hemolytic Anemia, Altered Oxygen Affinity, and Methemoglobinemias. Enzymopathies. Red Cell Membrane Disorders. Autoimmune Hemolytic Anemias. Extrinsic Nonimmune Hemolytic Anemias. Part V: Host Defense and Its Disorders. Immunoglobulins: Structure, Function, and Uses. Complement Biology. Neutrophil Structure and Function. Monocyte and Macrophage Development and Function. Eosinophils and the Hypereosinophilic Syndrome. Disorders of the Phagocyte Function. Disorders of the Lymphocyte Function. Histiocytic Syndromes. Lysosomal Storage Disease. Infectious Mononucleosis and Other Epstein-Barr Virus-Associated Diseases. Spleen and Its Disorders. Systemic Mastocytosis. Part VI: Hemat
Update on Avian Influenza A (H5N1) Virus Infection in Humans
Authors: Abdel-Nasser Abdel-Ghafar, Tawee Chotpitayasunondh, Zhancheng Gao, Frederick G Hayden, Duc Hien Nguyen, Menno D de Jong, Azim Naghdaliyev, J S Malik Peiris, Nahoko Shindo, Santoso Soeroso, Timothy M Uyeki
Journal: New England Journal of Medicine (2008)
AN ALARMING PRESSOR REACTION TO REGITINE
Authors: H J MARRIOTT
Journal: Annals of Internal Medicine (1957)

Case Reports1 May 1957AN ALARMING PRESSOR REACTION TO REGITINEHENRY J. L. MARRIOTT, M.D.HENRY J. L. MARRIOTT, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-46-5-1001 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptRegitine is generally considered safe for intravenous administration. A recent review by high authorities reiterates that its administration is followed by "no hazardous pressor responses when the patient has essential hypertension."1 It seems timely therefore to report an alarming reaction recently observed.CASE REPORTThe patient was a 53 year old Negro woman whose presenting complaint was precordial pain of anginal type. Her blood pressure was found to be 290/140 mm. of Hg, without pulsus alternans. Eyegrounds showed grade 2 changes. Arterialpulsation in the neck was marked but there was no venous distention. Premature ventricular beats were frequent, and...Bibliography1. KvaleRothWangerPriestley WFGMWMJT: Pheochromocytoma, Circulation 14: 622, 1956. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Baltimore, Maryland*Received for publication January 2, 1957.Requests for reprints should be addressed to Henry J. L. Marriott, M.D., University Hospital, Baltimore 1, Maryland. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byBibliographyEffect of Phentolamine and Tolazoline on Some Metabolic Processes of Heart Homogenates 1 May 1957Volume 46, Issue 5Page: 1001-1002KeywordsBlood pressureHypertensionOintmentsTachycardia ePublished: 1 December 2008 Issue Published: 1 May 1957 PDF downloadLoading ...
Abstract 20440: Cardiovascular Events in a Physical Activity Intervention as Compared to a Successful Aging Intervention: The LIFE Study Randomized Trial
Authors: Anne B Newman, John A Dodson, Timothy Church, Denise Bonds, Thomas Buford, Roger Fielding, Stephen Kritchevsky, Daniel P Beavers, Marco Pahor, Randall S Stafford, Anita D Szady, Mary M McDermott
Journal: Circulation (2014)

Background: There is little clinical trial evidence that sustained physical activity can prevent cardiovascular disease (CVD) in older adults. The LIFE Study was a multi-center randomized trial comparing sustained, structured physical activity (PA) to health education/successful aging (SA) to prevent mobility disability in older sedentary men and women. Cardiovascular morbidity and mortality was a secondary endpoint. Methods: Eligible participants (N=1635, 67% women, aged 70-89 years) were randomized to PA vs. SA. Eligibility criteria included being sedentary with a score &lt;10/12 on a short physical performance battery (SPPB), indicating higher risk for disability. Prevalent CVD was 30% at baseline. The PA intervention was a structured moderate intensity program, predominantly aerobic (walking), with resistance and flexibility exercises, at least five days weekly, 2x per week on site for 2.6 years on average. The SA intervention consisted of weekly health education sessions for six months, then monthly. CVD was assessed every 6 months, including fatal and non-fatal MI, angina, stroke and transient ischemic attack, peripheral artery disease including abdominal aortic aneurysm and all revascularizations. Hospital records were reviewed and adjudicated for CVD events by committee. Silent MI was assessed by ECG at 18 and 36 months. Results: Incident CVD occurred in 14.4% (n=118/818) of PA and 13.8% (113/817) of SA participants (HR=1.07, 95%CI=0.82-1.38. Using a narrower endpoint of MI, stroke or cardiovascular death, rates were 8.9% in PA and 8.7% in PA groups respectively with HR = 1.04 (95% CI=0.75-1.45). There were no significant differences in rates of incident vs. recurrent CVD. Among participants with SPPB &lt;8, CVD rates were 13.8% in PA vs 17.7% in SA with HR = 0.74 (95%CI=0.51-1.08), compared to 14.8% vs.10.5% (HR = 1.54 (95%CI=1.06-2.24) among those with SPPB of 8 or 9 (p for interaction = 0.007). Conclusions: Among participants in the LIFE Study, an aerobically-based, moderately intensive PA program did not reduce cardiovascular events overall. However, the intervention was more protective in lower functioning participants. Hypotheses to explain differences by functional status could be addressed with continued follow-up.
Glomerular clusterin is associated with PKC-α/β regulation and good outcome of membranous glomerulonephritis in humans
Authors: M.P. Rastaldi, G. Candiano, L. Musante, M. Bruschi, S. Armelloni, L. Rimoldi, R. Tardanico, S. Sanna Cherchi, F. Ferrario, V. Montinaro, R. Haupt, S. Parodi, M.L. Carnevali, L. Allegri, G. Camussi, L. Gesualdo, F. Scolari, G.M. Ghiggeri
Journal: Kidney International (2006)
A Challenge to Licensing Boards: The Stigma of Mental Illness
Authors: Steven H. Miles
Journal: JAMA (1998)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
A Walk at Dusk
Authors: M. Therese Southgate
Journal: JAMA (2004)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
<scp>d</scp>-Cycloserine vs Placebo as Adjunct to Cognitive Behavioral Therapy for Obsessive-Compulsive Disorder and Interaction With Antidepressants
Authors: Erik Andersson, Erik Hedman, Jesper Enander, Diana Radu Djurfeldt, Brjánn Ljótsson, Simon Cervenka, Josef Isung, Cecilia Svanborg, David Mataix-Cols, Viktor Kaldo, Gerhard Andersson, Nils Lindefors, Christian Rück
Journal: JAMA Psychiatry (2015)

It is unclear whether d-cycloserine (DCS), a partial N-methyl-d-aspartate agonist that enhances fear extinction, can augment the effects of exposure-based cognitive behavioral therapy (CBT) for obsessive-compulsive disorder (OCD).To examine whether DCS augments the effects of CBT for OCD and to explore (post hoc) whether concomitant antidepressant medication moderates the effects of DCS.A 12-week, double-blind randomized clinical trial with 3-month follow-up conducted at an academic medical center between September 4, 2012, and September 26, 2013. Participants included 128 adult outpatients with a primary diagnosis of OCD and a Yale-Brown Obsessive Compulsive Scale (Y-BOCS) score of 16 or higher. Concurrent antidepressant medication was permitted if the dose had been stable for at least 2 months prior to enrollment and remained unchanged during the trial. The main analysis was by intention-to-treat population.All participants received a previously validated Internet-based CBT protocol over 12 weeks and were randomized to receive either 50 mg of DCS or placebo, administered 1 hour before each of 5 exposure and response prevention tasks.Clinician-administered Y-BOCS score at week 12 and at 3-month follow-up. Remission was defined as a score of 12 or lower on the Y-BOCS.In the primary intention-to-treat analyses, DCS did not augment the effects of CBT compared with placebo (mean [SD] clinician-rated Y-BOCS score, DCS: 13.86 [6.50] at week 12 and 12.35 [7.75] at 3-month follow-up; placebo: 11.77 [5.95] at week 12 and 12.37 [6.68] at 3-month follow-up) but showed a significant interaction with antidepressants (clinician-rated Y-BOCS, B = -1.08; Z = -2.79; P = .005). Post hoc analyses revealed that antidepressants significantly impaired treatment response in the DCS group but not the placebo group, at both posttreatment and follow-up (clinician-rated Y-BOCS: t62 = -3.00; P = .004; and t61 = -3.49; P < .001, respectively). In the DCS group, a significantly greater proportion of antidepressant-free patients achieved remission status at follow-up (60% [95% CI, 45%-74%]) than antidepressant-medicated patients (24% [95% CI, 9%-48%]) (P = .008). Antidepressants had no effect in the placebo group (50% [95% CI, 36%-64%] remission rate in both groups).The findings suggest that antidepressants may interact with DCS to block its facilitating effect on fear extinction. Use of DCS may be a promising CBT augmentation strategy but only in antidepressant-free patients with OCD.clinicaltrials.gov Identifier: NCT01649895.
Hospitals release details of retained organs
Authors: Lynn Eaton
Journal: BMJ (2001)

About 100 NHS trusts have released information this week on organs which have been retained after postmortem examinations, following the work of the Retained Organs Commission, set up to oversee the proper return of organs and tissues to families who request it.

The commission, which officially came into force in April and has the status of a special health authority, has been working with trusts since January to ensure full and …