tbuckley/cabot-search huggingface dataset:
Phenotypically Distinct Target Cells for Murine Sarcoma Virus and Murine Leukemia Virus Marrow Transformation In Vitro&lt;xref ref-type="fn" rid="fn2"&gt;2&lt;/xref&gt;
Authors: J S Greenberger
Journal: JNCI Journal of the National Cancer Institute (1979)

An in vitro hematopoietic microenvironment was established from explanted fragments of bone marrow from adult nonlnbred NIH Swiss mice with the use of corticosteroid-reconstituted horse serum. Infection with Kirsten murine sarcoma virus (Ki-MuSV) with either a Rauscher murine leukemia virus (R-MuLV) or Balb:virus-1 helper virus coat reduced proliferation of granulocytic and pluripotenf hematopoietic stem cells and produced neoplastic transformation of both macrophages and preadipocytes in the adherent cell population within a 4-week period. Ki-MuSVtransformed, virus-releasing macrophages formed clusters of 4-49 cells in 0.8% methylcellulose-containing medium in the absence of added colony-stimulating factor (CSF), synthesized lysozyme, ASD-chloroacetate substrate-specific esterase-M, and CSF, and produced tumors following inoculation iv into adult NIH Swiss mice or ip into newborn NIH Swiss mice. In cultures infected with helper leukemia viruses R-MuLV or Balb:virus-1, gradual transformation of a distinct cell phenotype was observed over a 9-week period with generation of increasing numbers of atypical myeloblasts and promyelocytes which showed dyssynchronous nuclear-cytoplasmic maturation, basophilic granulation, cytoplasmic vacuolation, and formation of incompletely maturing CSF-dependent granulocyte-macrophage colonies in vitro and small spleen colonies in vivo. These data demonstrated that rapid biologic expression of the murine sarcoma virus genome in specific adherent "stromal" marrow cells prevents detection of a more subtle helper-virus-induced dysmyelopoiesis in a distinct nonadherent cell population.
Evaluation of latent tuberculosis infection in health care workers by QuantiFERON-TB Gold test and tuberculin skin test
Authors: Derya Yenibertiz, Dilek Kanmaz, Baris Yilmaz, Firdevs Atabey, Esin Tuncay
Journal: European Respiratory Journal (2011)

Introduction:  It is estimated one third of the world population is infected by mycobacterium tuberculosis (TB) and the risk factor of TB infection is contacting with TB patients.   Aim:  The aim of this study was to evaluate the parameters affecting the tuberculin skin test and QuantiFERON-TB Gold tests and the results of both tests used in health care workers for confirming latent tuberculosis infection (LTBI).   Method:  94 health care workers who work in Yedikule Chest Diseases and Surgery Hosital participated to this study.The demographic characteristics of cases, working hours and the number of BCG scar were recorded.Tuberculin skin test were applied to all patients and QuantiFERON levels were measured   Results:  The TST and QTF-G positivities had similar dispersion in gender groups and work types.There were a statistically significant relation between the levels of QTF with work times and ages of all participants. It was determined that there was a statistically significant relationship between positivity of QTF with TST psitivities and TST enduration diameters.   Conclusion:  In this study the findings indicated that QTF is very usefull in determining and following LTBI as a confirming test for healthcare workers who have close and longterm contact with tuberculosis patients and whose TST tests were positive.
Treatment of AIDS-related non-Hodgkin’s lymphoma with chemotherapy (CNOP) and r-hu-G-CSF: Clinical outcome and effect on HIV-1 viral load
Authors: M.J. Kersten, T.J. Verduyn, P. Reiss, L.M. Evers, F. de Wolf, M.H.J. van Oers
Journal: Annals of Oncology (1998)
The Mistreatment of Women during Childbirth in Health Facilities Globally: A Mixed-Methods Systematic Review
Authors: Meghan A. Bohren, Joshua P. Vogel, Erin C. Hunter, Olha Lutsiv, Suprita K. Makh, João Paulo Souza, Carolina Aguiar, Fernando Saraiva Coneglian, Alex Luíz Araújo Diniz, Özge Tunçalp, Dena Javadi, Olufemi T. Oladapo, Rajat Khosla, Michelle J. Hindin, A. Metin Gülmezoglu
Journal: PLoS Medicine (2015)

Background Despite growing recognition of neglectful, abusive, and disrespectful treatment of women during childbirth in health facilities, there is no consensus at a global level on how these occurrences are defined and measured. This mixed-methods systematic review aims to synthesize qualitative and quantitative evidence on the mistreatment of women during childbirth in health facilities to inform the development of an evidence-based typology of the phenomenon. Methods and Findings We searched PubMed, CINAHL, and Embase databases and grey literature using a predetermined search strategy to identify qualitative, quantitative, and mixed-methods studies on the mistreatment of women during childbirth across all geographical and income-level settings. We used a thematic synthesis approach to synthesize the qualitative evidence and assessed the confidence in the qualitative review findings using the CERQual approach. In total, 65 studies were included from 34 countries. Qualitative findings were organized under seven domains: (1) physical abuse, (2) sexual abuse, (3) verbal abuse, (4) stigma and discrimination, (5) failure to meet professional standards of care, (6) poor rapport between women and providers, and (7) health system conditions and constraints. Due to high heterogeneity of the quantitative data, we were unable to conduct a meta-analysis; instead, we present descriptions of study characteristics, outcome measures, and results. Additional themes identified in the quantitative studies are integrated into the typology. Conclusions This systematic review presents a comprehensive, evidence-based typology of the mistreatment of women during childbirth in health facilities, and demonstrates that mistreatment can occur at the level of interaction between the woman and provider, as well as through systemic failures at the health facility and health system levels. We propose this typology be adopted to describe the phenomenon and be used to develop measurement tools and inform future research, programs, and interventions.
&lt;italic&gt;Brief Communication:&lt;/italic&gt; Tumor Response in Strain A Mice Exposed to Silylating Compounds Used for Gas-Liquid Chromatography&lt;xref ref-type="fn" rid="fn2"&gt;2&lt;/xref&gt;
Authors: G D Stoner, E K Weisburger, M B Shimkin
Journal: JNCI Journal of the National Cancer Institute (1975)

Six reagents used to silylate, alkylate, or acyl ate compounds for ease of identification on gas chromatographic columns significantly increased the frequency of lung tumors in A/He mice.
Sebaceous carcinoma arising at a chronic candidiasis skin lesion of a patient with keratitis-ichthyosis-deafness (KID) syndrome
Authors: Y. Kaku, H. Tanizaki, M. Tanioka, J. Sakabe, A. Miyagawa-Hayashino, Y. Tokura, Y. Miyachi, K. Kabashima
Journal: British Journal of Dermatology (2011)

Journal Article Sebaceous carcinoma arising at a chronic candidiasis skin lesion of a patient with keratitis–ichthyosis–deafness (KID) syndrome Get access Y. Kaku, Y. Kaku Department of Dermatology, Kyoto University Graduate School of Medicine, 54 Shogoin‐Kawara, Sakyo, Kyoto 606‐8507, Japan Search for other works by this author on: Oxford Academic Google Scholar H. Tanizaki, H. Tanizaki Department of Dermatology, Kyoto University Graduate School of Medicine, 54 Shogoin‐Kawara, Sakyo, Kyoto 606‐8507, Japan Hideaki Tanizaki. E‐mail: tanizaki@kuhp.kyoto‐u.ac.jp Search for other works by this author on: Oxford Academic Google Scholar M. Tanioka, M. Tanioka Department of Dermatology, Kyoto University Graduate School of Medicine, 54 Shogoin‐Kawara, Sakyo, Kyoto 606‐8507, Japan Search for other works by this author on: Oxford Academic Google Scholar J. Sakabe, J. Sakabe Department of Dermatology, University of Occupational and Environmental Health, Kitakyushu, Japan Search for other works by this author on: Oxford Academic Google Scholar A. Miyagawa‐Hayashino, A. Miyagawa‐Hayashino Department of Diagnostic Pathology, Kyoto University Graduate School of Medicine, Kyoto, Japan Search for other works by this author on: Oxford Academic Google Scholar Y. Tokura, Y. Tokura Department of Dermatology, University of Occupational and Environmental Health, Kitakyushu, JapanDepartment of Dermatology, Hamamatsu University School of Medicine, Japan Search for other works by this author on: Oxford Academic Google Scholar Y. Miyachi, Y. Miyachi Department of Dermatology, Kyoto University Graduate School of Medicine, 54 Shogoin‐Kawara, Sakyo, Kyoto 606‐8507, Japan Search for other works by this author on: Oxford Academic Google Scholar K. Kabashima K. Kabashima Department of Dermatology, Kyoto University Graduate School of Medicine, 54 Shogoin‐Kawara, Sakyo, Kyoto 606‐8507, Japan Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 166, Issue 1, 1 January 2012, Pages 222–224, https://doi.org/10.1111/j.1365-2133.2011.10521.x Published: 01 January 2012
Chest wall tumor - dual thoracoscopic and open approach
Authors: Gabriel Cozma, Ioan Petrache, Alin Nicola, Ovidiu Burlacu
Journal: European Respiratory Journal (2014)

INTRODUCTION  Tumoral pathology of the chest wall is more common nowadays, even in young patients. Chest wall tumors usually requires extended surgery to acheieve oncological margins. In some cases the position of the tumoral formation makes it difficult to approach using classic tecniques and to acheive oncological margins, thus complementary thoracoscopic approach may be needed.  MATERIAL AND METHOD  We present the case of a 16 year old patient admitted in our clinic after a sport accident. Incidentally the chest xray identified a tumoral formation of the left 2nd rib. The CT scan revealed that the formation was limited only to the second rib, with osteolisis.  We decided to use both thoracoscopic and open approach. We created a port using the 4th intercostal space mid axillary line, and visualized the tumor; using the cautery we delimitated the resection area. Using the dissector we established the uitility incision site.  We then performed a 3 inch incision for the open approach and we started the endoscopic dissection of the tumoral formation. After the dissection was complete we proceeded with the rib resection using the utility incision and resected the tumor.  Chest wall reconstruction was performed using separated interlaced spider web stiches. One chest drain was placed.  RESULTS  The postoperative outcome was good, with no complications. The resection was within oncologic margins. Hospital stay was 4 days, with one day ICU care, with minimal analgetic treatment.  CONCLUSION  Dual approach was very useful for the resection, the magnification helped us to establish the macroscopic margins for the tumoral formation. The use of endoscopic dissection has the advantage of a minimal resection incision and minimal bleeding.
ADAM23 Negatively Modulates αvβ3 Integrin Activation during Metastasis
Authors: Newton V. Verbisck, Érico T. Costa, Fabrício F. Costa, Felícia P. Cavalher, Michele D.M. Costa, Angelita Muras, Valéria A. Paixão, Ricardo Moura, Mariana F. Granato, Daniela F Ierardi, Tamara Machado, Fabiana Melo, Karina B. Ribeiro, Isabela W. Cunha, Vladmir C.C. Lima, Maria do Socorro Maciel, André L. Carvalho, Fernando F. Soares, Silvio Zanata, Mari C. Sogayar, Roger Chammas, Anamaria A. Camargo
Journal: Cancer Research (2009)

Abstract The ADAM23 gene is frequently silenced in different types of tumors, and, in breast tumors, silencing is correlated with tumor progression, suggesting that it might be associated with the acquisition of a metastatic phenotype. ADAM23 exerts its function mainly through the disintegrin domain, because its metalloprotease domain is inactive. Analysis of ADAM23 binding to integrins has revealed a specific interaction with αvβ3 integrin mediated by the disintegrin domain. Altered expression of αvβ3 integrin has been observed in different types of tumors, and expression of this integrin in the activated form has been shown to promote metastasis formation. Here, we investigated the possibility that interaction between ADAM23 and αvβ3 integrin might negatively modulate αvβ3 activation during metastatic progression. ADAM23 expression was knocked down using short hairpin RNA in the MDA-MB-435 cell line, which has been extensively used as a model for αvβ3 integrin activation. Ablation of ADAM23 enhanced αvβ3 integrin activation by at least 2- to 4-fold and ADAM23 knockdown cells showed enhanced migration and adhesion to classic αvβ3 integrin ligands. Ablation of ADAM23 expression also enhanced pulmonary tumor cell arrest in immunodeficient mice. To complement our findings with clinical evidence, we showed that silencing of ADAM23 gene by DNA promoter hypermethylation in a collection of 94 primary breast tumors was significantly associated with lower distant metastases–free and disease-specific survivals and was an independent prognostic factor for poor disease outcome. Our results strongly support a functional role of ADAM23 during metastatic progression by negatively modulating αvβ3 integrin activation. [Cancer Res 2009;69(13):5546–52]
Effects of chlormadinone acetate, acetazolamide and oxygen on awake and asleep gas exchange in patients with chronic obstructive pulmonary disease (COPD)
Authors: PJ Vos, HT Folgering, TM de Boo, WJ Lemmens, CL van Herwaarden
Journal: European Respiratory Journal (1994)

The purpose of this study was to assess the short-term effects of chlormadinone acetate (CMA), a synthetic progestogen, acetazolamide (ACET) and oxygen on awake and asleep blood gas values. The study was conducted according to a randomized, double-blind and placebo-controlled design in 53 hypoxaemic patients with chronic obstructive pulmonary disease. On the first two consecutive nights, all patients received either room air or oxygen, via a nasal cannula, in random order. They then received either CMA (25 mg), ACET (250 mg) or placebo twice a day, all in identical capsules. On the third study night, after one week of drug treatment, the patients were tested breathing room air. CMA and ACET therapy decreased mean daytime arterial carbon dioxide tension (PaCO2) by 0.7 and 0.5 kPa, respectively, and night-time end-tidal carbon dioxide tension (PETCO2) by 0.5 and 0.3 kPa, respectively. Supplemental oxygen caused increased CO2 retention during the day and night (0.6 and 0.3 kPa, respectively. Daytime arterial oxygen tension (PaO2) increased to the same extent during ACET (1.9 kPa) and oxygen (2.5 kPa). Asleep oxygen saturation improved most with oxygen supplementation (7%), although ACET also caused significant improvement (4%). CMA administration had virtually no effect on mean awake and asleep hypoxaemia. ACET therapy significantly improved subjective sleep quality. On CMA, minute ventilation increased in association with an augmentation of the hypercapnic ventilatory response. ACET treatment increased both hypercapnic and hypoxic ventilatory responses. We conclude from the group of patients with COPD studied, that the short-term effects of ACET treatment on gas exchange compare favourably with those of CMA. Oxygen therapy improves oxygenation slightly more than ACET, but aggravates CO2 retention.
Comparison of the Duke activity status index and the incremental Shuttle walk test in COPD
Authors: Katy Wagg, Johanna Williams, Sally Singh
Journal: European Respiratory Journal (2011)

The Duke Activity Status Index (DASI) was developed as a simple tool of assessment of functional status for people with congestive heart failure (CHF)and correlated well with VO2max derived from cycle ergonometry and 6-minute walk distance in patients with COPD. Peak oxygen uptake correlates well with the Incremental Shuttle Walk Test (ISWT) which is commonly used to prescribe exercise in pulmonary rehabilitation. The aim was to establish whether VO2max predicted by the DASI compares well with that predicted by the ISWT and therefore whether the DASI could be used to support prescription of a training programme.

153 COPD patients (75 male; mean (SD) Age 70 (9.36)yrs; FEV1 1.34 (0.57)l; BMI 28.36 (6.75)) completed the DASI and the ISWT. Mean VO2max predicted from the DASI was 17.69 ml/min/kg and 10.03ml/min/kg from the ISWT, a significant difference of 7.67 (95%CI= 7.0-8.32)p<0.001. A Bland and Altman plot shows that there is poor agreement between the 2 measures (Fig1). There was moderate correlation between VO2max predicted by the DASI and ISWT (r=0.55,p<0.001).

![Figure][1] 



Although there is a correlation between the DASI and the ISWT, poor agreement indicates that the measures cannot be used interchangeably and that the DASI cannot be used to prescribe a training programme for individuals with COPD.

 [1]: pending:yes
Dietary vitamin E supplement does not inhibit changes in lung pressure-volume characteristics produced by bleomycin in hamsters
Authors: S Sato, H Nakamura, K Takada, K Takahashi
Journal: European Respiratory Journal (1988)

We tested the hypothesis that a dietary supplement of vitamin E (VE) may lessen changes in pulmonary pressure-volume characteristics induced by intratracheal instillation of bleomycin. Ninety-nine male hamsters were separated into a control group (C), a VE supplement group (E), a control plus bleomycin group (CB) and a VE supplement plus bleomycin group (EB). Animals were killed at 30, 40, 55, 70 and 90 days and the pressure-volume curves of their lungs, both air-filled and saline-filled, were determined. Bleomycin was instilled on the thirtieth day. Lung volumes, compliance and curve-fitting data were compared. The mean serum VE concentration was 17.5 micrograms.ml-1 in groups E and EB as compared to 5.7 micrograms.ml-1 in groups C and CB. Despite the remarkably high VE content, no significant difference was found between groups CB and EB for the parameters compared.
CIRCULATORY RATINGS IN MENTALLY DEFECTIVE ADOLESCENT CHILDREN
Authors: Philip J. Trentzsch
Journal: American Journal of Psychiatry (1926)

1. A circulatory rating test was used during the war to aid in detecting aviators who were unstable, and therefore were not in condition to fly at that time. 2. In applying this test to a group of psychotic cases it was found that 82.61 per cent of the hebephrenic and catatonic types of dementia præcox patients rated low and that only 26.9 per cent of the paranoid types of dementia præcox rated low. Also only 11.2 per cent of the manic depressive patients rated low. 3. In 4800 necropsies reported by Lewis (3) he found that 71.55 per cent of the hebephrenic and catatonic types of dementia præcox had a small aplastic heart, the incomplete development involving also the capillary system. Furthermore 75.5 per cent of these cases had hearts of less than average weight, while only 7.8 per cent of the paranoid dementia præcox had hearts of less than average weight. 4. The circulatory rating test was revised by me so that it could be applied on adolescent children between the ages of 10 and 15 years. 5. The revised test was applied to 100 adolescent children in the public schools of the District of Columbia, all of whom were in the same grade but in three different groups, having been rated by a psychological test and placed accordingly. 6. Out of the 1OO children rated by my revised circulatory test, 26 were in the advanced class, and four of these, or an average of 15.3 per cent, rated below 10. Forty-five pupils were in the middle class and four of these, or an average of 8.9 per cent, rated below 10 points; and finally 29 pupils were in the retarded class, and seven of these, or an average of 24.4 per cent, rated below 10 points. This showing that the more or less stable middle class had the smallest average of pupils rating below 10 points. 7. When this list of 15 pupils, who had a low rating was presented to the principal of the school she stated that all of them were problem children, and the histories obtained from both the teachers and the pupils showed many neurotic symptoms. 8. The revised test was performed on 100 adolescent feeble-minded children in the Waverley School for Feeble-Minded and only two pupils graded below 10 points. One of these pupils had an organic heart disease, both were of the familial type of feeble-minded, and neither was syphilitic. 9. As a group, the mental defects graded high in the circulatory rating test. 10. In reading the literature on the pathology of the mental-defect one finds very little concerning the cardio-vascular system. 11. The circulatory test seems a valuable instrument for detecting a certain special type of individual. Eighty-two and sixty-one-hundreds per cent of the hebephrenic and catatonic dementia præcox type rated low. The 15 per cent of the public school children who had neurotic symptoms rated low. While practically none of the adolescent feeble-minded children graded low.
Asthma self-management programmes in a population of Italian children: a multicentric study. Italian Study Group on Asthma Self-Management Programmes
Authors: R Ronchetti, L Indinnimeo, E Bonci, A Corrias, D Evans, M Hindi-Alexander, F Midulla, R Pulejo, MP Villa
Journal: European Respiratory Journal (1997)

This study was designed to answer three main questions: 1) Does asthma self-management education reduce asthma morbidity? 2) Are the two programmes "Living With Asthma" and "Open Airways" equally effective in doing so? 3) Is a shortened version of these programmes (4 weeks) as effective as the longer original programme (8 weeks)? Twelve Italian centres of paediatric bronchopneumology selected 312 children with asthma, who were stratified by disease severity, gender and age, and then randomly assigned to an Experimental group which received an educational programme or to a Comparison group, which did not. Of the 312 children selected, 209 (114 Experimental and 95 Comparison) completed the educational protocol and a 1 year follow-up. Data recorded during the last 2 months of follow-up, 10 months after the educational intervention, showed that the Experimental group required significantly fewer emergency treatments: this reduction was more evident in the more severe asthma cases. In the Experimental, but not in the Comparison group, patients with more severe asthma consumed more medications than patients with milder asthma "Open Airways" yielded, in some cases, better results than "Living with Asthma": but a type 2 error is possible. The standard and the shortened programmes proved equally effective. In conclusion, following education, regardless of receiving a short or long educational programme, asthma patients use emergency care services less and use medications more appropriately in comparison with standard care without education. This suggests that short educational programmes can be highly cost-effective in children with asthma.
Systematic reviews and meta-analyses in infectious diseases: topics that merit special attention
Authors: L. Leibovici, D. Yahav, M. Paul
Journal: Clinical Microbiology and Infection (2013)

As in other disciplines in medicine, systematic reviews (SR) and meta-analyses (MA) in infectious diseases are an important aid to clinical decision-making. In the present article we review features important to SRs in infectious diseases that should be addressed in most SRs and MAs. We stress the need to include in the SR analysis all patients that were randomized; and all studies that were performed. Authors of SRs should choose one main outcome that matters to patients, and base their conclusions mainly on this outcome. Resistance as an outcome is a topic that should be addressed in all SRs of antibiotic treatment. Ethical aspects and especially patients' safety should be addressed in SRs.