tbuckley/cabot-search huggingface dataset:
Day hospitals and centres for disturbed children in the London area.
Authors: A Bentovim, R Lansdown
Journal: BMJ (1973)

Several hospitals and child guidance units in the London area have recently found it necessary to extend the educational facilities for disturbed children, and have established day centres or day hospitals, where psychiatric care can be given to children and their families for several hours daily. At a day-conference organized recently by the National Association of Mental Health at the Hospital Centre, London, members of the seven units in the London area took part in a discussion on their common and individual problems. The following arises out of the contributions to this conference.
Modifiable Determinants of Serum 25-Hydroxyvitamin D Status in Early Childhood
Authors: Jonathon L. Maguire, Catherine S. Birken, Marina Khovratovich, Julie DeGroot, Sarah Carsley, Kevin E. Thorpe, Muhammad Mamdani, Patricia C. Parkin, for the TARGet Kids! Collaboration
Journal: JAMA Pediatrics (2013)

OBJECTIVES To determine the effect of modifiable dietary intake variables (current vitamin D supplementation and daily cow's milk intake) on 25-hydroxyvitamin D level in early childhood and to evaluate the relationship between these modifiable dietary factors and other largely nonmodifiable determinants of vitamin D status including skin pigmentation and season. DESIGN Cross-sectional study. SETTING Primary care pediatric and family medicine practices participating in the TARGet Kids! practice-based research network in Toronto, Ontario, Canada. PARTICIPANTS From December 2008 to June 2011, healthy children 1 to 5 years of age were recruited during a routine physician's visit. INTERVENTIONS Survey, anthropometric measurements, and laboratory data were collected. A multivariable linear regression model was developed to examine the independent effects of vitamin D supplementation and daily volume of cow's milk on 25-hydroxyvitamin D level. MAIN OUTCOME MEASURES 25-Hydroxyvitamin D level. RESULTS Blood was obtained in 1898 children. Two modifiable dietary intake variables, vitamin D supplementation and cow's milk, increased 25-hydroxyvitamin D level by 3.4 ng/mL (95% CI, 2-4 ng/mL) and 1.6 ng/mL per 250-mL cup per day (95% CI, 1-2 ng/mL), respectively. Two nonmodifiable variables reflecting cutaneous vitamin D synthesis (skin pigmentation and season) were also strongly associated with 25-hydroxyvitamin D status but accounted for a much smaller proportion of the explained variation in 25-hydroxyvitamin D level. The effect of vitamin D supplementation and milk intake on 25-hydroxyvitamin D level appeared similar regardless of skin pigmentation or season. CONCLUSION Two modifiable dietary intake variables (vitamin D supplementation and cow's milk intake) are the most important determinants of 25-hydroxyvitamin D status in early childhood.
519 INITIAL ENDOSCOPIO RETROGRADE CHOLANGIOGRAPHY (ERC) FAILURE IN PATIENTS WITH ANASTOMOTIC STRICTURES AFTER LIVER TRANSPLANTATION (LT): RISK FACTORS AND EFFECTIVENESS OF SECOND-UNE TREATMENTS
Authors: P. Balderramo, J. Bordas, O. Sendino, J. Llach, A. Cardenas
Journal: Journal of Hepatology (2011)
Novel mechanism by which histone deacetylase inhibitors facilitate topoisomerase IIα degradation in hepatocellular carcinoma cells
Authors: Mei Chuan Chen, Chun-Han Chen, Hsiao Ching Chuang, Samuel K. Kulp, Che Ming Teng, Ching Shih Chen
Journal: Hepatology (2010)

Histone deacetylase (HDAC) inhibitors exhibit a unique ability to degrade topoisomerase (topo)IIα in hepatocellular carcinoma (HCC) cells, which contrasts with the effect of topoII-targeted drugs on topoIIβ degradation. This selective degradation might foster novel strategies for HCC treatment in light of the correlation of topoIIα overexpression with the aggressive tumor phenotype and chemoresistance. Here we report a novel pathway by which HDAC inhibitors mediate topoIIα proteolysis in HCC cells. Our data indicate that HDAC inhibitors transcriptionally activated casein kinase (CK)2α expression through increased association of acetylated histone H3 with the CK2α gene promoter. In turn, CK2 facilitated the binding of topoIIα to COP9 signalosome subunit (Csn)5 by way of topoIIα phosphorylation. Furthermore, we identified Fbw7, a Csn5-interacting F-box protein, as the E3 ligase that targeted topoIIα for degradation. Moreover, knockdown of CK2α, Csn5, or Fbw7 reversed HDAC inhibitor-induced topoIIα degradation. Mutational analysis indicates that the 1361SPKLSNKE1368 motif plays a crucial role in regulating topoIIα protein stability. This motif contains the consensus recognition sites for CK2 (SXXE), glycogen synthase kinase (GSK)3β (SXXXS), and Fbw7 (SPXXS). This study also reports the novel finding that topoIIα may be a target of GSK3β phosphorylation. Evidence suggests that CK2 serves as a priming kinase, through phosphorylation at Ser1365, for GSK3β-mediated phosphorylation at Ser1361. This double phosphorylation facilitated the recruitment of Fbw7 to the phospho-degron 1361pSPKLpS1365 of topoIIα, leading to its ubiquitin-dependent degradation. Conclusion : This study shows a novel pathway by which HDAC inhibitors facilitate the selective degradation of topoIIα, which underlies the complexity of the functional role of HDAC in regulating tumorigenesis and aggressive phenotype in HCC cells. (Hepatology 2011;)
Some Reflections on the Coronary Bypass Operation
Authors: WILLIAM W. L. GLENN
Journal: Circulation (1972)

A promising new operation-coronary bypass-has been developed for the treatment of coronary heart disease. However, because of the nature of the underlying disease and the minute size of the vessels to be anastomosed, its long-range prospects are in doubt. At this point in time there is no evidence that the operation either prevents infarction or prolongs life, and great caution is urged in applying it, reserving it for those who have life-threatening coronary artery disease, are clearly recalcitrant to optimum medical management, and have apparently normal coronary vessels distal to the point of stenosis. There is an urgent need for a better definition of the indications for operation in patients with coronary artery disease based on a study of the natural history of this coindition. Prophylactic operation for patients with a compromised coronary circulation with or without angina must await long-term results of therapeutic operation.
NOTICE TO THE BOARD OF TRUSTEES.
Authors: P. O. Hooper
Journal: JAMA (1891)

Office of the Board of Trustees of the American Medical Association, Little Rock, Ark., April 5, 1891.  The Annual Meeting of the Board of Trustees of the American Medical Association will be convened in the parlors of the Arlington Hotel, at Washington, D. C., on Saturday, May 2, at 10 o'clock A.M.
Comment on Tovote et al. Individual Mindfulness-Based Cognitive Therapy and Cognitive Behavior Therapy for Treating Depressive Symptoms in Patients With Diabetes: Results of a Randomized Controlled Trial. Diabetes Care 2014;37:2427–2434
Authors: Veronica Y. Womack, Mercedes R. Carnethon
Journal: Diabetes Care (2015)

The study by Tovote et al. (1) was the first randomized clinical trial to examine the effectiveness of individual mindfulness-based cognitive therapy in reducing depressive symptoms in patients with diabetes. However, the researchers did not account for the racial/ethnic background of the participants. Compared with the general population, African Americans are disproportionately affected by diabetes and diabetes-related complications. For some African Americans, the stress of diabetes compounded by higher levels of chronic life stressors (e.g., financial insecurity, low education level, lack of health care) makes them particularly vulnerable to complications from the synergistic effects of obesity, diabetes, …
Creative Portrayals of a Mad, Sad World
Authors: Lynne Lamberg
Journal: JAMA (1999)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Effect of Breast Magnetic Resonance Imaging on the Clinical Management of Women With Early-Stage Breast Carcinoma
Authors: Gayle F. Tillman, Susan G. Orel, Mitchell D. Schnall, Delray J. Schultz, Jacqueline E. Tan, Lawrence J. Solin
Journal: Journal of Clinical Oncology (2002)

PURPOSE: To determine the impact of breast magnetic resonance imaging (MRI) on the clinical management of patients with early-stage breast cancer. PATIENTS AND METHODS: A review was performed of the records of 207 women with early-stage breast cancer (including five women with bilateral disease) who underwent breast MRI during work-up for breast conservation treatment. All patients presented with clinical stage 0, I, or II disease. For each patient, a determination was made whether the breast MRI affected the clinical management, and if so, whether the patient was well served by the change in management. RESULTS: The MRI findings affected the clinical management in 43 cases (20% of 212 breast cancers). Based on the pathology findings and the overall clinical course for each case, the breast MRI was judged to have had a strongly favorable effect on management in 18 cases (8%), a somewhat favorable effect in six cases (3%), an uncertain effect in five cases (2%), a somewhat unfavorable effect in 11 cases (5%), and a strongly unfavorable effect in three cases (1%). The effect of MRI was not significantly different for invasive carcinoma compared with ductal carcinoma-in-situ (all P ≥ .27). However, the effect of MRI was significantly greater when the MRI was performed before an excisional biopsy (P = .0011) or for larger tumors (P = .0089). CONCLUSIONS: Breast MRI alters the clinical management for a sizable fraction of women with early-stage breast cancer and appears to offer clinically useful information for determining optimal local treatment.
Pregnancy and Obsessive-Compulsive Disorder
Authors: DAN J. STEIN, ERIC HOLLANDER, DAPHNE SIMEON, LISA COHEN, MICHAEL HWANG
Journal: American Journal of Psychiatry (1993)

Trichotillomania, a disorder characterized by repetitive hair pulling, has been only recently systemically investigated. Such research was encouraged by data that showed obsessive-compulsive disorder, which is also characterized by ritual behaviors, responds selectively to serotonin reuptake inhibitors. In this review, we consider similarities and contrasts in the diagnosis, demographics, phenomenology, neurochemistry, neuropsychiatry, and treatment of trichotillomania and obsessive-compulsive disorder. We argue that a view of trichotillomania as an obsessive-compulsive spectrum disorder that may involve disturbances in grooming behaviors comprises a useful clinical and research heuristic. Nevertheless, there may also be important differences between the two disorders; in particular, trichotillomania has a number of characteristics in common with impulsive disorders. Further empirical investigation is necessary to determine the nature of these complex disorders and their relationship to one another.
Deubiquitinating enzyme CYLD negatively regulates RANK signaling and osteoclastogenesis in mice
Authors: Wei Jin, Mikyoung Chang, Emmanuel M. Paul, Geetha Babu, Andrew J. Lee, William Reiley, Ato Wright, Minying Zhang, Jun You, Shao-Cong Sun
Journal: Journal of Clinical Investigation (2008)

Osteoclastogenesis is a tightly regulated biological process, and deregulation can lead to severe bone disorders such as osteoporosis. The regulation of osteoclastic signaling is incompletely understood, but ubiquitination of TNF receptor–associated factor 6 (TRAF6) has recently been shown to be important in mediating this process. We therefore investigated the role of the recently identified deubiquitinating enzyme CYLD in osteoclastogenesis and found that mice with a genetic deficiency of CYLD had aberrant osteoclast differentiation and developed severe osteoporosis. Cultured osteoclast precursors derived from CYLD-deficient mice were hyperresponsive to RANKL-induced differentiation and produced more and larger osteoclasts than did controls upon stimulation. We assessed the expression pattern of CYLD and found that it was drastically upregulated during RANKL-induced differentiation of preosteoclasts. Furthermore, CYLD negatively regulated RANK signaling by inhibiting TRAF6 ubiquitination and activation of downstream signaling events. Interestingly, we found that CYLD interacted physically with the signaling adaptor p62 and thereby was recruited to TRAF6. These findings establish CYLD as a crucial negative regulator of osteoclastogenesis and suggest its involvement in the p62/TRAF6 signaling axis.
Intraerythrocytic Parasitosis in Humans with<i>Entopolypoides</i>Species (Family Babesiidae)
Authors: ROBERT E. WOLF
Journal: Annals of Internal Medicine (1978)

We have observed two cases of human infection with intraerythrocytic protozoa. The organisms appeared to be in the Entopolypoides group, which has not previously been associated with human infection. One patient was asplenic. Both patients had hepatic dysfunction, and their serum samples contained blocking factors that interfered in vitro with the stimulation of normal lymphocytes by phytohemagglutinin. It appears that in humans, as well as in experimental animals, host factors are important in resistance to infection by intraerythrocytic parasites. These factors include the presence of a spleen and cell-mediated and humoral immunities. Possibly similar infections will be observed in patients with other impairments of T-cell function, such as those induced by malignancy, thymic dysfunction, or immunosuppressive drugs.
Expression of Bcl-2 by human bone marrow mast cells and its overexpression in mast cell leukemia
Authors: Carlos Cerver�, Luis Escribano, Jes�s F. San Miguel, Beatriz D�az-Agust�n, Pilar Bravo, Jes�s Villarrubia, Ram�n Garc�a-Sanz, Jos� L. Velasco, Pilar Herrera, Mario Vargas, Marcos Gonz�lez, Jos� L. Navarro, Alberto Orfao
Journal: American Journal of Hematology (1999)

Bcl-2 protein plays a major role in the prevention of programmed cell death of differentiating cells. In the present study, the expression of cytoplasmic bcl-2 by human Bone Marrow Mast Cells (BMMC) from both normal and pathological bone marrow samples was examined. A total of 35 subjects corresponding to 9 healthy volunteers, 8 cases of adult indolent systemic mast cell disease (SMCD), 4 cases of pediatric mastocytosis (PM), 11 cases of hematological malignancies (HM), 2 cases of reactive bone marrow, and 1 case of mast cell leukemia (MCL) were analyzed. The expression of bcl-2 was studied using quantitative three-color flow cytometry. We also studied the molecular configuration of the bcl-2 gene and other relatives by Southern blot and polymerase chain reaction (PCR) in the MCL case. Bcl-2 expression was detected in BMMC from all samples analyzed. No significant differences on the expression of bcl-2 were detected between BMMC from healthy subjects and patients with SMCD, PM, HM, and reactive bone marrow. By contrast, bcl-2 protein was overexpressed in BMMC from MCL patient without gene rearrangement. Our results show that bcl-2 protein was constitutively expressed by BMMC. BMMC from MCL display overexpression of bcl-2, which could not be related to molecular rearrangements involving the bcl-2 gene. The expression of this protein by mature MC may play a role in the prevention of MC apoptosis and thus help to explain the long survival of these cells. The overexpression of bcl-2 by BMMC in MCL may help to explain their resistance to chemotherapy-induced apoptosis. Am. J. Hematol. 60:191–195, 1999. © 1999 Wiley-Liss, Inc.
Quantification of the 3H-ouabain binding site concentration in human myocardium: a postmortem study
Authors: A. NORGAARD, K. KJELDSEN, O. HANSEN, T. CLAUSEN, C. G. LARSEN, F. G. LARSEN
Journal: Cardiovascular Research (1986)

Journal Article Quantification of the 3H-ouabain binding site concentration in human myocardium: a postmortem study Get access AAGE NØRGAARD, AAGE NØRGAARD **From the Institute of Physiology, University of Aarhus, Aarhus C, Denmark Search for other works by this author on: Oxford Academic PubMed Google Scholar KELD KJELDSEN, KELD KJELDSEN **From the Institute of Physiology, University of Aarhus, Aarhus C, Denmark Search for other works by this author on: Oxford Academic PubMed Google Scholar OTTO HANSEN, OTTO HANSEN **From the Institute of Physiology, University of Aarhus, Aarhus C, Denmark Search for other works by this author on: Oxford Academic PubMed Google Scholar TORBEN CLAUSEN, TORBEN CLAUSEN **From the Institute of Physiology, University of Aarhus, Aarhus C, Denmark Search for other works by this author on: Oxford Academic PubMed Google Scholar CHRISTIAN GRØNHØJ LARSEN, CHRISTIAN GRØNHØJ LARSEN †From the Department of Medicine C, Aarhus Municipal Hospital, Aarhus C, Denmark Search for other works by this author on: Oxford Academic PubMed Google Scholar FREDERIK GRØNHØJ LARSEN FREDERIK GRØNHØJ LARSEN †From the Department of Medicine C, Aarhus Municipal Hospital, Aarhus C, Denmark Search for other works by this author on: Oxford Academic PubMed Google Scholar Cardiovascular Research, Volume 20, Issue 6, June 1986, Pages 428–435, https://doi.org/10.1093/cvr/20.6.428 Published: 01 June 1986
ROLE OF PERCUTANEOUS BALLOON AORTIC VALVULOPLASTY FOR CALCIFIC AORTIC STENOSIS: UPDATED TECHNIQUE, INDICATIONS AND IMMEDIATE HAEMODYNAMIC RESULTS IN A HIGHLY EXPERIENCED CENTER
Authors: Akira Furuta, Karim Bejar, Helene Eltchaninoff, Christophe Tron, Brahim Baala, Matthieu Godin, Carlos Sanchez Giron, Bogdan Borz, Alain Cribier
Journal: Journal of the American College of Cardiology (2010)
Colonoscopic Evaluation of Severe Hematochezia in an Oriental Population
Authors: K. Y. Y. Kok, C. K. Kum, P. M. Y. Goh
Journal: Endoscopy (1998)

Background and Study Aims: Hematochezia is a common clinical problem. When the bleeding is brisk and continuous it requires prompt hospital admission and careful diagnostic evaluation and management. Colonoscopy has become the first-line investigative modality in patients presenting with severe hematochezia in many centers, including ours. A retrospective review was carried out to evaluate the effectiveness of colonoscopy in determining the cause of severe hematochezia in our Oriental population.
Nutritional Regulation of the Insulin-Like Growth Factors*
Authors: JEAN-PAUL THISSEN, JEAN-MARIE KETELSLEGERS, LOUIS E. UNDERWOOD
Journal: Endocrine Reviews (1994)

INSULIN-LIKE growth factor-I (IGF-I) and IGF-II growth factors that are structurally related to insulin (Table 1). The human IGFs (refered to generically as somatomedins) are single chain peptides of 7.5 kilodaltons (kDa), composed of 70 and 67 amino acid residues for IGF-I and IGF-II, respectively (1–3). Four domains, designated A, B, C, and D are identified in the IGF molecules; the A and B domains being homologous with the A and B chains of insulin, respectively. In contrast with most hormonal peptides, the IGFs are secreted as they are produced. Consequently, there are no organs in which IGFs are concentrated. The liver is believed to be the principal source of circulating IGF-I (4–6) but the highest concentrations of IGFs are observed in blood (7). The IGFs are produced in most organs (8, 9) and exert biological effects on most cell types (10, 11). The ubiquity of sites of production and action has led to the concept that these peptides act by autocrine and paracrine mechanisms (12, 13) as well as by classical endocrine mechanisms (14).
Polymorphism of human acetyltransferases.
Authors: U A Meyer
Journal: Environmental Health Perspectives (1994)

Acetylation by arylamine N-acetyltransferases (NATs) is a major route in the metabolism of numerous drugs and carcinogens. Recent studies suggest that the same enzymes also catalyze N,O-transacetylation and O-acetylation. A genetic polymorphism of clinical relevance divides the human population into slow and rapid acetylators of arylamines. Two human NATs, NAT1 and NAT2, have recently been characterized by protein purification, cloning, and functional expression of the respective genes; both were localized to chromosome 8. NAT1 codes for a protein with ubiquitous tissue distribution and a high affinity for p-aminobenzoic acid and p-aminosalicylic acid, so-called monomorphic substrates. NAT2 codes for a protein predominantly expressed in liver with a high affinity for sulfamethazine and other polymorphically metabolized drugs. NAT2 was analyzed at the level of protein, RNA and DNA derived from phenotyped slow and rapid acetylators. Two common (M1, M2) and one rare (M3) mutant allele were identified and their mutations characterized. A simple polymerase chain reaction-based DNA test can identify > 95% of mutant alleles and predict the phenotype.
Effect of Age on Pulse Wave Velocity and "Aortic Ejection Time" in Healthy Men and in Men with Coronary Artery Disease
Authors: ERNST SIMONSON, K. NAKAGAWA
Journal: Circulation (1960)

Impedance plethysmograms were taken in 51 healthy men and 42 normotensive men with coronary heart disease from the aorta near the place of auscultation of the aortic valve and from the femoral artery in the femoral triangle recorded simultaneously with the 3 electrocardiographic standard leads. The aortic pulse wave velocity was determined from the time interval between the foot points of the aortic and femoral volume pulse, and the anatomic distance between the electrodes. It increases with age in normal subjects as well as in patients, but the values are significantly higher in the patients. These results are suggestive of accelerated degenerative changes in the aorta, probably due to atherosclerosis. The interval from the earliest detectable QRS deflection to the foot point of the aortic volume pulse ("aortic ejection time") becomes longer with age in the normal group. In patients with coronary artery disease, the prolongation is significantly larger for each of 3 age subgroups. The results suggest that ventricular ischemia affects ventricular isometric contraction.
The Rac GTPase effector p21-activated kinase is essential for hematopoietic stem/progenitor cell migration and engraftment
Authors: Adrienne M. Dorrance, Serena De Vita, Maria Radu, Pavankumar N. G. Reddy, Meaghan K. McGuinness, Chad E. Harris, Ronald Mathieu, Steven W. Lane, Rachelle Kosoff, Michael D. Milsom, Jonathan Chernoff, David A. Williams
Journal: Blood (2013)