Diffuse Systemic Scleroderma
Authors: DENNY L. TUFFANELLI
Journal: Annals of Internal Medicine (1962)

Article1 August 1962Diffuse Systemic SclerodermaA Comparison with AcrosclerosisDENNY L. TUFFANELLI, M.D., R. K. WINKELMANN, M.D.DENNY L. TUFFANELLI, M.D.Search for more papers by this author, R. K. WINKELMANN, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-57-2-198 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptMost early classifications of scleroderma were based solely on the distribution of cutaneous lesions, and early texts (1, 2) divided scleroderma into localized and generalized forms only. Hutchinson (3) first associated scleroderma with Raynaud's phenomenon in 1896. The concept that there were 2 types of systemic scleroderma, "acrosclerosis" (scleroderma with Raynaud's phenomenon) and "diffuse scleroderma" (scleroderma without vasospastic change) was postulated by Sellei (4) in Europe, and by O'Leary and Waisman (5) in this country. This differentiation has many advocates (6-8), but many doubt its usefulness (9-12). As the multiple systemic findings of the disease became better known, other authors...References1. BESNIERBROCQJACQUET ELL: La Pratique Dermatologique: Traité de Dermatologique Appliquée, 4 vols., Masson & Cie, Paris, 1900-1904. Google Scholar2. HEBRAKAPOSI FM: Lehrbuch der Hautkrankheiten, 2 vols., Verlag von Ferdinand Enke, Erlangen, 1874. Google Scholar3. HUTCHINSON J: Cases demonstrated at the clinical museum: acro-scleroderma following Raynaud's phenomena. Clin. J. 7: 240, 1896. Google Scholar4. SELLEI J: Die Akrosklerosis (Sklerodaktylie) und deren Symptomenkomplex nebst neueren Untersuchungen bei Sklerodermie. Arch. Dermat. Syph. 163: 343, 1931. CrossrefGoogle Scholar5. O'LEARYWAISMAN PAM: Acrosclerosis. Proc. Mayo Clin. 15: 702, 1940. Google Scholar6. INGRAM JT: Acrosclerosis and systemic sclerosis. Arch. Derm. 77: 79, 1958. CrossrefGoogle Scholar7. ŠŤÁVA Z: The problem of interrelation between diffuse generalized scleroderma, acrosclerosis, Raynaud's phenomenon and Raynaud's disease: a clinical study based on an analysis of 70 cases. Dermatologica (Basel) 118: 1, 1959. CrossrefGoogle Scholar8. TRUELOVEWHYTE SCHM: Acrosclerosis. Brit. Med. J. 2: 873, 1951. CrossrefMedlineGoogle Scholar9. BEIGELMANGOLDNERBAYLES PMFTB: Progressive systemic sclerosis (scleroderma). New Engl. J. Med. 249: 45, 1953. CrossrefMedlineGoogle Scholar10. JABLONSKABUBNOWLUKASIAK SBB: Raynaud's syndrome; acrosclerosis; scleroderma. Brit. J. Derm. 70: 37, 1958. CrossrefMedlineGoogle Scholar11. LEINWANDDURYEERICHTER IAWMN: Scleroderma (based on a study of over 150 cases). Ann. Intern. Med. 41: 1003, 1954. LinkGoogle Scholar12. ROTHMANWALKER SS: Scleroderma. Med. Clin. N. Amer. January, 1949, p. 55. CrossrefMedlineGoogle Scholar13. GOETZ RH: The pathology of progressive systemic sclerosis (generalized scleroderma): with special references to changes in the viscera. Clin. Proc. 4: 337, 1945. Google Scholar14. PAGELTREIP WCS: Viscero-cutaneous collagenosis: a study of the intermediate forms of dermatomyosites, scleroderma, and disseminated lupus erythematosus. J. Clin. Path. 8: 1, 1955. CrossrefMedlineGoogle Scholar15. TUFFANELLIWINKELMANN DLRK: Systemic scleroderma: a clinical study of 727 cases. Arch. Derm. 84: 359, 1961. CrossrefMedlineGoogle Scholar16. TUFFANELLI DL: Scleroderma: A Twenty Year Study. Thesis, Graduate School, University of Minnesota, 1961. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Rochester, MinnesotaFrom the Mayo Clinic and Mayo Foundation, Rochester, Minnesota.Dr. Tuffanelli is a Fellow in Dermatology, Mayo Foundation.Requests for reprints should be addressed to Mayo Clinic, Rochester, Minnesota. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited BySystematic Analysis of the Literature in Search of Defining Systemic Sclerosis SubsetsVery early systemic sclerosisThere is a need for new systemic sclerosis subset criteria. 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WEINBERGER, M.D., F.A.C.P.Chronic disease of the liver associated with systemic scleroderma 1 August 1962Volume 57, Issue 2_Part_1Page: 198-203KeywordsArthritisDermatologyEdemaLesionsRaynaud syndromeSclerodermaSystemic diseases Issue Published: 1 August 1962 PDF DownloadLoading ...