Prevalence of Familial Dysalbuminemic Hyperthyroxinemia in Hispanics
Authors: DIANA R. DECOSIMO
Journal: Annals of Internal Medicine (1987)

Letters and Corrections1 November 1987Prevalence of Familial Dysalbuminemic Hyperthyroxinemia in HispanicsDIANA R. DECOSIMO, M.D., SHIH-LIEH FANG, Ph.D., LEWIS E. BRAVERMAN, M.D.DIANA R. DECOSIMO, M.D., SHIH-LIEH FANG, Ph.D., LEWIS E. BRAVERMAN, M.D.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-107-5-780_2 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: Familial dysalbuminemic hyperthyroxinemia is a recently recognized autosomal dominant syndrome often confused with thyrotoxicosis in laboratory tests (1-3). This syndrome is characterized by elevations in the serum thyroxine concentration, free thyroxine index, and free thyroxine concentration measured by radioimmunoassay using125I-labeled thyroxine analogs (4) and normal serum triiodothyronine concentrations, due to a serum albumin that preferentially binds thyroxine and, rarely, triiodothyronine or reverse triiodothyronine (5). However, serum free thyroxine concentrations measured by equilibrium dialysis or by radioimmunoassay using tracer125I-thyroxine are normal and the patients are euthyroid with normal thyroid suppression tests and basal and thyrotrophin-releasing-hormone-stimulated serum...References1. LEEGOLDENVAN DERLELEIPPEKAPLAN WMABS. Inherited abnormal thyroid hormone-binding protein causing selective increase in total serum thyroxine. J Clin Endocrinol Metab. 1979;49:292-9. CrossrefMedlineGoogle Scholar2. STOCKIGTTOPLISSBARLOWWHITEHURLEYTAFT JDHEDP. Familial euthyroid thyroxine excess: an appropriate response to abnormal thyroxine binding associated with albumin. J Clin Endocrinol Metab. 1981;53:353-9. CrossrefMedlineGoogle Scholar3. RUIZRAJATANAVINYOUNG MMR. Familial dysalbuminemic hyperthyroxinemia: a syndrome that can be confused with thyrotoxicosis. N Engl J Med. 1982;306:635-9. CrossrefMedlineGoogle Scholar4. RAJATANAVINFOURNIERDECOSIMOABREAUBRAVERMAN RLDCL. Elevated serum free thyroxine by thyroxine analog radioimmunoassays in euthyroid patients with familial dysalbuminemic hyperthyroxinemia. Ann Intern Med. 1982;97:865-6. LinkGoogle Scholar5. LALLOZBYFIELDHIMSWORTH MPR. A new and distinctive albumin varient with increased affinities for both triiodothyroxones and causing hyperthyroxinaemia. Clin Endocrinol. 1985;22:521-9. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: DIANA R. DECOSIMO, M.D.; SHIH-LIEH FANG, Ph.D.; LEWIS E. BRAVERMAN, M.D.Affiliations: University of Massachusetts Medical School Worcester, MA 01655 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byFree thyroxine measurement in clinical practice: how to optimize indications, analytical procedures, and interpretation criteria while waiting for global standardizationHormone Immunoassay Interference: A 2021 UpdateAn Update on the Pathophysiology and Diagnosis of Inappropriate Secretion of Thyroid-Stimulating HormoneThe Free Hormone Hypothesis: When, Why, and How to Measure the Free Hormone Levels to Assess Vitamin D, Thyroid, Sex Hormone, and Cortisol StatusClinical recognition and evaluation of patients with inherited serum thyroid hormone-binding protein mutationsA Chinese Family with Familial Dysalbuminemic Hyperthyroxinemia (FDH) due to R242H Mutation on Human Albumin Gene: Reevaluating the Role of FDH in Patients with Asymptomatic HyperthyroxinemiaAdmixture, Genetics and Complex Diseases in Latin Americans and US HispanicsDirectional thyroid hormone distribution via the blood stream to target sitesSeven Familial Dysalbuminemic Hyperthyroxinemia Cases in Three Unrelated Japanese Families and High-Performance Liquid Chromatography Analysis of the Thyroxine Binding ProfileFirst Report of Familial Dysalbuminemic Hyperthyroxinemia With an ALB VariantInherited defects of thyroxine-binding proteinsA Novel Albumin Gene Mutation (R222I) in Familial Dysalbuminemic HyperthyroxinemiaHuman serum albumin: From bench to bedsideAn Outline of Inherited Disorders of the Thyroid Hormone Generating SystemFamilial Dysalbuminemic Hyperthyroxinemia: A Rare Example of Albumin Polymorphism and its Rapid Molecular DiagnosisClinical Aspects and Diagnosis of Thyroid Hormone Transport Protein AnomaliesFamilial Dysalbuminemic Hyperthyroxinemia in a Hispanic FamilyJILL M. KUNITAKE, M.D., JEROME M. HERSHMAN, M.D., JERALD C. NELSON, M.D. 1 November 1987Volume 107, Issue 5Page: 780-781KeywordsAttentionEquilibrium dialysisHispanic peopleHyperthyroxinemiaLaboratory testsRadioimmunoassaysSerum albuminThyroidThyroxineTriiodothyronine ePublished: 1 December 2008 Issue Published: 1 November 1987 PDF downloadLoading ...