SULFONAMIDES: PASSAGE INTO SPINAL FLUID AND RECTAL ABSORPTION
Authors: Windsor C. Cutting, Ernest H. Sultan
Journal: Annals of Internal Medicine (1942)

Article1 April 1942SULFONAMIDES: PASSAGE INTO SPINAL FLUID AND RECTAL ABSORPTIONWINDSOR C. CUTTING, M.D., ERNEST H. SULTAN, A.B.WINDSOR C. CUTTING, M.D.Search for more papers by this author, ERNEST H. SULTAN, A.B.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-16-4-708 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe increasing importance of sulfathiazole in the treatment of bacterial infections makes it desirable to elucidate any differences from the more familiar sulfanilamide, particularly concerning distribution in the body. Thus it has been thought that sulfathiazole penetrated into the spinal fluid less readily than sulfanilamide, and was also less readily absorbed from the rectum. This report presents results on these aspects of the sulfonamides in animals and patients.SPINAL FLUID PENETRATIONSadusk and coauthors,1in 1940, claimed that spinal fluid concentrations of sulfathiazole, from 0 to 25 per cent of the simultaneous blood values, occurred after four hours of administration...References1. SADUSK JE: Observations on absorption, excretion, diffusion and acetylation of sulfathiazole in man, Yale Jr. Biol. and Med., 1940, xii, 681-696. Google Scholar2. CAREY BW: Use of sulfanilamide and related compounds in diseases of infancy and childhood, Jr. Am. Med. Assoc., 1940, cxv, 924-929. CrossrefGoogle Scholar3. MARSHALL EK: Para-aminobenzenesulfonamide, Jr. Am. Med. Assoc., 1937, cviii, 953-957. CrossrefGoogle Scholar4. REINHOLD JG: Observations on pharmacology and toxicology of sulfathiazole in man, Am. Jr. Med. Sci., 1940, cxcix, 393-401. CrossrefGoogle Scholar5. HARTMANN AF: Present status of therapy with sulfanilamide and sulfapyridine, Jr. Missouri Med. Assoc., 1940, xxxvii, 41-54. Google Scholar6. NEAL J: Sulfapyridine and its sodium salt in the treatment of meningitis, Jr. Am. Med. Assoc., 1940, cxv, 2055-2058. CrossrefGoogle Scholar7. MARINO A: Rectal administration of sulfanilamide, Med. Times, 1940, lxviii, 110-112. Google Scholar8. TURELL R: Absorption of sulfanilamide from the large intestine, Ann. Surg., 1940, cxii, 417-420. CrossrefGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: San Francisco, California*Received for publication September 9, 1941.From the Departments of Pharmacology and of Medicine, Stanford University School of Medicine, San Francisco, California.Supported, in part, by the Rockefeller Fluid Research Fund of Stanford University School of Medicine. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byTetrahydrobiopterin Biosynthesis as an Off-Target of Sulfa DrugsThe Influence of Suppository Bases Upon the Rectal Absorption of Acetylsalicylic AcidBarreira hemoencefálica 1 April 1942Volume 16, Issue 4Page: 708-715KeywordsAttentionBloodPharmacologyRectumResearch fundingSulfonamide ePublished: 1 December 2008 Issue Published: 1 April 1942 PDF downloadLoading ...