Antibiotic Prophlaxis in Acute Leukemia
Authors: CARLOS A. DE JONGH
Journal: Annals of Internal Medicine (1981)

Letters and Corrections1 December 1981Antibiotic Prophlaxis in Acute LeukemiaCARLOS A. DE JONGH, M.D., STEPHEN C. SCHIMPFF, M.D., PETER H. WIERNIK, M.D.CARLOS A. DE JONGH, M.D.Search for more papers by this author, STEPHEN C. SCHIMPFF, M.D.Search for more papers by this author, PETER H. WIERNIK, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-95-6-783_3 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: The recent article by Dekker and colleagues (1) addresses an issue of concern, especially to those treating patients with acute leukemia receiving oral antibiotic prophylaxis: namely, is there a risk of infection with resistant microorganisms?Since van de Waaij and colleagues (2) advanced the concept of colonization resistance in 1972, selective microbial suppression of the alimentary canal has been explored as an approach to substitute for the use of oral nonabsorbable antibiotics (3, 4) which, although effective in reducing serious infections, also have significant disadvantages (5). Several studies of trimethoprim-sulfamethoxazole or nalidixic acid have been reported or...References1. DEKKERROSENBERG-ARSKASIXMAVERHOEF AMJJ. Prevention of infection by trimethoprim-sulfamethoxazole plus amphotericin B in patients with acute nonlymphocytic leukaemia. Ann Intern Med. 1981;95:555-9. LinkGoogle Scholar2. VAN DER WAAIJBERGHUISLEKKERKERK DJJ. Colonization resistance of digestive tract of mice during systemic antibiotic treatment. J Hyg (Camb). 1972;70:605-10. CrossrefMedlineGoogle Scholar3. GUIOTVAN FURTH HR. Partial antibiotic decontamination. Br Med J. 1977;1:800-2. CrossrefMedlineGoogle Scholar4. SLEIJFERMULDERDE VRIES-HOSPERS DNH. Infection prevention in granulocytopenic patients by selective decontamination of the digestive tract. Eur J Cancer. 1980;16:859-69. CrossrefMedlineGoogle Scholar5. SCHIMPFF S. Infection prevention during profound granulocytopenia: new approaches to alimentary canal microbial suppression. Ann Intern Med. 1980;93:358-61. LinkGoogle Scholar6. GURWITHBRUNTONLANKHARDINGRONALD MJBGA. A prospective controlled investigation of prophylactic trimethoprim/sulfamethoxazole in hospitalized granulocytopenic patients. Am J Med. 1979;66:248-56. CrossrefMedlineGoogle Scholar7. WADESCHIMPFFHARGADONFORTNERYOUNGWIERNIK JSMCVP. A comparison of trimethoprim/sulfamethoxazole plus nystatin with gentamicin plus nystatin in the prevention of infections in acute leukemia. N Engl J Med. 1981;304:1057-62. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Baltimore Cancer Research Center Baltimore, MD 21201 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByPrevention of Infection by Gramnegative MicroorganismsProtecting neutropenic patients from bowel-derived organismsPrevention of Infections in Granulocytopenic Patients by Fluorinated QuinolonesSpontaneous bacterial peritonitis: Prevention and therapyPrevention of bacterial and fungal infections in granulocytopenic patientsEcological Impacts of Antibacterial Agents: Stockholm, March 7–8, 1986Prevention of infection among patients with cancerColistin and trimethoprim-sulfamethoxazole for the prevention of infection in patients with acute non-lymphocytic leukaemia. Decrease in the emergence of resistant bacteriaTrimethoprim/sulfamethoxazole prophylaxis in neutropenic patients 1 December 1981Volume 95, Issue 6Page: 783-784KeywordsAntibiotic prophylaxisAntibiotic resistance Issue Published: 1 December 1981 PDF DownloadLoading ...