THE NEWER ANALGESIC DRUGS; THEIR USE AND ABUSE
Authors: Harris Isbell
Journal: Annals of Internal Medicine (1948)

Article1 December 1948THE NEWER ANALGESIC DRUGS; THEIR USE AND ABUSEHARRIS ISBELLHARRIS ISBELLSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-29-6-1003 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptAlthough morphine has been regarded for over a hundred years as the most effective and reliable compound for the relief of the more severe grades of pain, the drug has many undesirable properties. It produces respiratory depression; it increases the activity and tone of the smooth muscle of the gastrointestinal, biliary, and urinary tracts, causing constipation, spasm of the gall-bladder and bile ducts, and urinary retention; it frequently causes nausea and vomiting; and it may induce itching of the skin. If morphine has to be administered over a long period of time, tolerance to the analgesic effect develops so that...Bibliography1. SMALLEDDYMOSETTIGHIMMELSBACH LFNBECK: Studies on drug addiction, Supplement No. 138, Pub. Health Reports, 1938. Google Scholar2. KLEIDERERRICECONQUESTWILLIAMS ECMBVJH: Pharmaceutical activities at the I. G. Farbenindustrie Plant, Hoechst am Main, 1945, Washington, D. C., Office of the Publication Board, Department of Commerce, Report No. PB 981. Google Scholar3. WOLFFHARDYGOODELL HGJDH: Studies on pain. Measurement of the effect of morphine, codeine, and other opiates on the pain threshold and an analysis of their relation to the pain experience, Jr. Clin. Invest., 1940, xix, 659. CrossrefGoogle Scholar4. EDDY NB: Metopon, Jr. Am. Pharm. Assoc., 1947, viii, 430. Google Scholar5. LEE LE: Studies of morphine, codeine and their derivations. XVL. Clinical studies of morphine, methyldihydromorphinone (metopon) and dihydrodesoxymorphinone-D (desomorphine), Jr. Pharmacol. and Exper. Therap., 1942, lxxv, 161. Google Scholar6. LEE LE: Medication in the control of pain in terminal cancer with reference to the study of newer synthetic analgesics, Jr. Am. Med. Assoc., 1941, cxvi, 239. Google Scholar7. BATTERMAN RC: Clinical effectiveness and safety of a new synthetic analgesic drug, demerol, Arch. Int. Med., 1943, lxxi, 345. CrossrefGoogle Scholar8. BATTERMANHIMMELSBACH RCCK: Demerol—a new synthetic analgesic. A review of its present status and comparison with morphine, Jr. Am. Med. Assoc., 1943, cxxii, 222. CrossrefGoogle Scholar9. BATTERMAN RC: Demerol: a new synthetic analgesic; its indications as a substitute for morphine, Conn. State Med. Jr., 1944, viii, 13. Google Scholar10. NOTHHECHTYONKMAN PHHHFF: Demerol: a new synthetic analgetic, spasmolytic and sedative agent. II. Clinical observations, Ann. Int. Med., 1944, xxvi, 17. Google Scholar11. CLIMENKOBERG DRH: The influence of demerol on the ureter, Jr. Urol., 1943, xlix, 255. CrossrefGoogle Scholar12. SCOTTCHEN CCKK: The action of 1,1-diphenyl-1-(dimethylaminoisopropyl)-butanone-2, a potent analgesic agent, Jr. Pharmacol. and Exper. Therap., 1946, lxxxvii, 63. Google Scholar13. SCOTTCHENKOHLSTAEDTROBBINSISRAEL CCKKKGEBFW: Further observations on the pharmacology of 'dolophine' (Methadon, Lilly), Jr. Pharmacol. and Exper. Therap., 1947, xci, 147. Google Scholar14. HAAGFINNEGANLARSON HBJKPS: Pharmacologic observations on 1,1-diphenyl-1-(dimethylaminoisopropyl)-butanone-2, Fed. Proc., 1947, vi, 334. Google Scholar15. WIKLERFRANKEISENMAN AKAJ: Effects of single doses of 10820 (4-4-diphenyl-6-dimethylamino-heptanone-3) on the nervous system of dogs and cats, Fed. Proc., 1947, vi, 384. Google Scholar16. EDDY NB: A new morphine-like analgesic, Jr. Am. Pharm. Assoc., 1947, viii, 536. Google Scholar17. ISBELLEISENMANWIKLERFRANK HAJAK: The effects of single doses of 6-dimethylamino-4-4-diphenyl-3-heptanone (amidone, methadon, or '10820') on human subjects, Jr. Pharmacol. and Exper. Therap., 1948, xcii, 83. Google Scholar18. ISBELLWIKLEREDDYWILSONMORAN HANBJLC: Tolerance and addiction liability of 6-dimethylamino-4-4-diphenyl-heptanone-3 (methadon), Jr. Am. Med. Assoc., 1947, cxxxv, 888. CrossrefGoogle Scholar19. HIMMELSBACHSMALL CKLF: Clinical studies of drug addiction. II. Rossium treatment of drug addiction, Supplement No. 125, Pub. Health Rep., 1947. Google Scholar20. ANDREWS HL: The development of tolerance to demerol, Jr. Pharmacol. and Exper. Therap., 1942, lxxv, 338. Google Scholar21. HIMMELSBACH CK: Studies of certain addiction characteristics of (a) dihydromorphine ("paramorphan"), (b) dihydro-desoxymorphine-D ("desomorphine"), (c) dihydrodesoxycodeine-D ("desocodeine"), and (d) methyldihydromorphinone ("metopon"), Jr. Pharmacol. and Exper. Therap., 1939, lxvii, 239. Google Scholar22. HIMMELSBACH CK: Studies of the addiction liability of "demerol" (D-140), Jr. Pharm. and Exper. Therap., 1942, lxxv, 64. Google Scholar23. HIMMELSBACH CK: Further studies of the addiction liability of demerol (1-methyl-4-phenyl-piperidine-4-carboxylic acid ethyl ester hydrochloride), Jr. Pharm. and Exper. Therap., 1943, lxxix, 5. Google Scholar24. KIRCHHOFDAVID ACNA: Clinical trial of a new synthetic heptanone and analgesic, West. Jr. Surg. and Obst., 1947, lv, 183. Google Scholar25. ISBELL H: Unpublished observations. Google Scholar26. WIEDER H: Addiction to meperidine hydrochloride (demerol hydrochloride). Report of three cases, Jr. Am. Med. Assoc., 1946, cxxxii, 1066. CrossrefGoogle Scholar27. ANDREWS HL: Cortical effects of demerol, Jr. Pharmacol. and Exper. Therap., 1942, lxxvi, 89. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: *Presented at the Twenty-Ninth Annual Session of the American College of Physicians, San Francisco, April 19, 1948.From the Department of Research, U. S. Public Health Service Hospital, Lexington, Kentucky. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byOpiates: Human PsychopharmacologyMethadone-Induced Behavioral Changes: Circular Movements, Aggression, and Electrophysiological AspectsMethadone: A Bibliography, 1929–1971, Part 2AnalgetikaAnalgetikaZur Frage der letalen Dosis und des Nachweises von PolamidonZwei beobachtungen von ateml�hmung nach polamidonmi�brauch�ber die Messung analgetischer Wirkungen im Tierversuch II.Manifestations and Treatment of Addiction to Narcotic Drugs and Barbiturates 1 December 1948Volume 29, Issue 6Page: 1003-1013KeywordsAnalgesicsBiliary systemConstipationDrugsMedical servicesMorphineNauseaPruritusSmooth musclesVomiting ePublished: 1 December 2008 Issue Published: 1 December 1948 PDF downloadLoading ...