tbuckley/cabot-search huggingface dataset:
Quality of randomised controlled trials: Caution is important
Authors: N. J Brewer
Journal: BMJ (2004)

Neurological disorders such as epilepsy arise from disrupted brain networks. Our capacity to treat these disorders is limited by our inability to map these networks at sufficient temporal and spatial scales to target interventions. Current best techniques either sample broad areas at low temporal resolution (e.g. calcium imaging) or record from discrete regions at high temporal resolution (e.g. electrophysiology). This limitation hampers our ability to understand and intervene in aberrations of network dynamics. Here we present a technique to map the onset and spatiotemporal spread of acute epileptic seizures <i>in vivo</i> by simultaneously recording high bandwidth microelectrocorticography and calcium fluorescence using transparent graphene microelectrode arrays. We integrate dynamic data features from both modalities using non-negative matrix factorization to identify sequential spatiotemporal patterns of seizure onset and evolution, revealing how the temporal progression of ictal electrophysiology is linked to the spatial evolution of the recruited seizure core. This integrated analysis of multimodal data reveals otherwise hidden state transitions in the spatial and temporal progression of acute seizures. The techniques demonstrated here may enable future targeted therapeutic interventions and novel spatially embedded models of local circuit dynamics during seizure onset and evolution.
Health in the Guatemalan Highlands
Authors: Ralph Crawshaw
Journal: JAMA (1984)

Are you weary of bad news about the health of the millions who eke out an existence in the Third World? Of the dollars of government aid mindlessly wasted through bureaucratic bungling and corruption? Well, here is an antidote to all that is frightful in the account of the US intervention in Central America.<i>Health in the Guatemalan Highlands</i>is a brief tale told with words of the people and illustrated with their faces, smiling or in pain, but always replete with human dignity. This is a true tale with that rarest of modern plots—a genuine hero who sets out to make a difference for the poorest of the poor, and who succeeded. The book tells the saga of Dr Carroll Behrhorst, profiled in the<i>JAMA</i>CONTEMPO issue 1980;243:2139, whom I know through his membership on the Steering Committee of the Club of Kos. In 1962, Dr Behrhorst left his
Case-control studies of leukaemia clusters.
Authors: P G Smith
Journal: BMJ (1991)

carbon caused a fivefold to sixfold decrease in production of toxins, although removing phosphorus had no effect."1After the Rutland incident the Department of Health warned recreational users to avoid contact with algal scum and water close to it, and this message has been incorporated into a leaflet issued by the National Rivers Authority.The authority regularly monitors the quality of inland waters and now screens for the presence of blooms of potentially toxic blue- green algae.Toxic algae have already killed many animals, and humans are also at risk of illness and death.Better understanding of the biochemistry, physiology, and toxicology ofcyanobacteria is needed to keep these risks to a minimum.
Enhanced drug targeting by attachment of an anti αv integrin antibody to doxorubicin loaded human serum albumin nanoparticles
Authors: Sylvia Wagner, Florian Rothweiler, Marion G. Anhorn, Daniel Sauer, Iris Riemann, Eike C. Weiss, Alisa Katsen-Globa, Martin Michaelis, Jindrich Cinatl, Daniel Schwartz, Jörg Kreuter, Hagen von Briesen, Klaus Langer
Journal: Biomaterials (2009)
Commentary: Statistical problems
Authors: G D Smith, M Egger
Journal: BMJ (1994)

occur.For the time being trainee surgeons will stiU be exposed to open gastrectomies, pancreatectomies, and other complex procedures, but as laparoscopic surgery becomes more and more advanced and these more complicated procedures become available to the laparoscopic approach, training in all open procedures will be a problem for the future.
Recombinant transforming growth factor beta 1 and beta 2 protect mice from acutely lethal doses of 5-fluorouracil and doxorubicin.
Authors: K Grzegorzewski, F W Ruscetti, N Usui, G Damia, D L Longo, J A Carlino, J R Keller, R H Wiltrout
Journal: The Journal of Experimental Medicine (1994)

Transforming growth factor beta 1 (TGF-beta 1) and TGF-beta 2 can reversibly inhibit the proliferation of hematopoietic progenitor cells in vivo, leading us to hypothesize that such quiescent progenitors might be more resistant to high doses of cell cycle active chemotherapeutic drugs, thereby allowing dose intensification of such agents. Initial studies showed that whereas administration of TGF-beta 1 or TGF-beta 2 did not prevent death in normal mice treated with high doses of 5-fluorouracil (5-FU), those mice that received TGF-beta 2 did exhibit the beginning of a hematologic recovery by day 11 after administration of 5-FU, and were preferentially rescued by a suboptimal number of transplanted bone marrow cells. Subsequently, it was found that the administration of TGF-beta 2 protected recovering progenitor cells from high concentrations of 5-FU in vitro. This protection coincided with the finding that significantly more progenitors for colony-forming unit-culture (CFU-c) and CFU-granulocyte, erythroid, megakaryocyte, macrophage (GEMM) were removed from S-phase by TGF-beta in mice undergoing hematopoietic recovery than in normal mice. Further studies showed that the administration of TGF-beta protected up to 90% of these mice undergoing hematologic recovery from a rechallenge in vivo with high dose 5-FU, while survival in mice not given TGF-beta was &amp;lt; 40%. Pretreatment of mice with TGF-beta 1 or TGF-beta 2 also protected 70-80% of mice from lethal doses of the noncycle active chemotherapeutic drug, doxorubicin hydrochloride (DXR). These results demonstrate that TGF-beta can protect mice from both the lethal hematopoietic toxicity of 5-FU, as well as the nonhematopoietic toxicity of DXR. This report thus shows that a negative regulator of hematopoiesis can be successfully used systemically to mediate chemoprotection in vivo.
<i>In vitro</i> reconstructed skin models for wound coverage in deep burns
Authors: F. BERTHOD, O. DAMOUR
Journal: British Journal of Dermatology (1997)

Journal Article In vitro reconstructed skin models for wound coverage in deep burns Get access F. BERTHOD, F. BERTHOD Laboratoire d'Organogenèse Expèrimentale, Hópital du Saint‐Sacrement, 1050 Chemin de Saihte‐Fay, GIS 4L8 Quèbec Search for other works by this author on: Oxford Academic Google Scholar O. DAMOUR O. DAMOUR Laboratoire des Substituts Cutanés, HôHpital Edouard Herriot, Lyon, 69437 France Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 136, Issue 6, 1 June 1997, Pages 809–816, https://doi.org/10.1111/j.1365-2133.1997.tb03917.x Published: 01 June 1997 Article history Accepted: 11 January 1997 Published: 01 June 1997
Immunopathogenesis of HIV Infection
Authors: Vijay V. Yeldandi
Journal: Annals of Internal Medicine (1998)

Medical Writings1 March 1998Immunopathogenesis of HIV InfectionVijay V. Yeldandi, MDVijay V. Yeldandi, MDLoyola University Stritch School of Medicine, Maywood, IllinoisSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-128-5-199803010-00021 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail Fauci AS, Pantaleo G; eds. 153 pages. New York: Springer-Verlag; 1997. $124.00. ISBN 3540632549. Order phone 800-777-4643.Field of medicine: Infectious disease and immunology.Format: Hardcover book.Audience: Basic scientists, students, and other health care professionals involved with the care of patients with HIV infection.Purpose: To review research findings relevant to the immunopathogenesis of HIV infection.Content: This is a collection of review articles describing the biology of HIV infection and its effect on the human host. The articles review the interactions of HIV with constituents of the human immune system.Highlights: This concise collection touches on the highlights ... Author, Article, and Disclosure InformationAffiliations: Loyola University Stritch School of Medicine, Maywood, Illinois PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 March 1998Volume 128, Issue 5Page: 416KeywordsHIVHIV infectionsImmunologyInfectious diseasesLymphoid tissuePathogenesisPatientsScientistsTouchVaccines ePublished: 15 August 2000 Issue Published: 1 March 1998 Copyright & PermissionsCopyright © 1998 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Hepatic Arterial Infusion of Chemotherapy as a Salvage Therapy for Patients with Advanced Hepatocellular Carcinoma
Authors: Shao Yu-Yun, Liang Po-Chin, Wu Yao-Ming, Huang Chun-Chieh, Huang Kai-Wen, Cheng Jason Chia-Hsien, Hsu Chih-Hung, Hsu Chiun, Cheng Ann-Lii, Lin Zhong-Zhe
Journal: Annals of Oncology (2014)
Influence of evaluation of clinical pictures on the histopathologic diagnosis of inflammatory skin disorders
Authors: Lorenzo Cerroni, Zsolt Argenyi, Rino Cerio, Fabio Facchetti, Harald Kittler, Heinz Kutzner, Luis Requena, Omar P. Sangueza, Bruce Smoller, Janine Wechsler, Helmut Kerl
Journal: Journal of the American Academy of Dermatology (2010)
Abstract 4685: SH2D4A is frequently downregulated in hepatocellular carcinoma.
Authors: Mariacarla Andreozzi, Luca Quagliata, Michal Kovac, Luigi Tornillo, Zuzanna Makowska, Marcus Heim, Karl Heinimann, Salvatore Piscuoglio, Luigi Maria Terracciano
Journal: Cancer Research (2013)

Abstract Hepatocellular carcinoma (HCC) is the third leading cause of cancer-related death worldwide. The lack of effective therapeutic options combined with an increasing incidence rate in the past 20 years calls for the identification of early stage HCC molecular markers. SH2D4A maps to human chromosome 8p21.3 and encodes for SH(2)A. The chromosomal region containing SH2D4A has been shown to be frequently lost in colorectal, lung and HCC cancers. Using a combination of gene expression, protein level and clinical data, our study aimed to investigate the SH2D4A involvement in HCC pathogenesis. Transcriptome analysis (Affymetrix) performed on 37 HCC samples (matched with their corresponding non-neoplastic liver parenchyma) and 5 normal liver donors revealed that SH2D4A is downregulated in HCC. These results were validated by qPCR in fresh frozen tissues [25 out of 37 samples (67.6%) showed SH2D4A downregulation; p&amp;lt;0.026]. Furthermore, the combination of qPCR data and immunohistochemistry staining performed on corresponding formalin-fixed paraffin embedded (FFPE) needle biopsies demonstrated a direct correlation between the SH2D4A mRNA expression and SH(2)A protein levels. Additional data obtained from the analysis of a tissue microarray (TMA) containing 336 informative specimens confirmed that SH(2)A protein levels are frequently reduced in HCC and additionally in cirrhosis nodules compared to normal liver samples. To conclude, our study revealed that SH2D4A is frequently downregulated in HCC samples thus corroborating its putative role as tumor suppressor gene. In addition, we provide new evidence for SH2D4A involvement in HCC pathogenesis demonstrating for the first time its deregulation also in cirrhotic nodules. Citation Format: Mariacarla Andreozzi, Luca Quagliata, Michal Kovac, Luigi Tornillo, Zuzanna Makowska, Marcus Heim, Karl Heinimann, Salvatore Piscuoglio, Luigi Maria Terracciano. SH2D4A is frequently downregulated in hepatocellular carcinoma. [abstract]. In: Proceedings of the 104th Annual Meeting of the American Association for Cancer Research; 2013 Apr 6-10; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2013;73(8 Suppl):Abstract nr 4685. doi:10.1158/1538-7445.AM2013-4685 Note: This abstract was not presented at the AACR Annual Meeting 2013 because the presenter was unable to attend.
Prospective randomized trial of intravenous and intracoronary streptokinase in acute myocardial infarction.
Authors: W J Rogers, J A Mantle, W P Hood, W A Baxley, P L Whitlow, R C Reeves, B Soto
Journal: Circulation (1983)

To evaluate the relative thrombolytic efficacy and complications of intracoronary vs high-dose, short-term intravenous streptokinase infusion in patients with acute myocardial infarction, we performed baseline coronary arteriography and then randomly allocated 51 patients with acute myocardial infarction to receive either intracoronary (n = 25) or intravenous (n = 26) streptokinase. Patients getting the drug by the intracoronary route received 240,000 IU of streptokinase into the infarct-related artery over 1 hr, whereas those getting the drug by the intravenous route received either 500,000 IU of streptokinase over 15 min (n = 10) or 1 million IU of streptokinase over 45 min (n = 16). Angiographically observed thrombolysis occurred in 76% (19/25) of the patients receiving intracoronary streptokinase, in 10% (1/10) of the patients receiving 500,000 IU of streptokinase intravenously, and in 44% (7/16) of the patients receiving 1 million IU of streptokinase intravenously. Among patients in whom thrombolysis was observed, mean elapsed time from onset of streptokinase infusion until lysis was 31 +/- 18 min in patients receiving intracoronary streptokinase and 38 +/- 20 min in those receiving intravenous streptokinase (p = NS). Among patients in whom intravenous streptokinase "failed," intracoronary streptokinase in combination with intracoronary guidewire manipulation recanalized only 7% (1/15). Fibrinogen levels within 6 hr after streptokinase were significantly lower in the patients receiving intravenous streptokinase (39 +/- 17 mg/dl) than the levels in those receiving intracoronary streptokinase (88 +/- 70 mg/dl) (p less than .05) but were similar 24 hr after streptokinase in the two groups. Bleeding requiring transfusion occurred in one patient in each group. Thus, in this prospective randomized trial of intracoronary vs intravenous streptokinase, hemorrhagic complications were few, although both regimens produced a systemic lytic state. Although the thrombolytic efficacy of intracoronary streptokinase was superior to that of high-dose, short-term intravenous streptokinase, the higher-dose intravenous regimen (1 million IU over 45 min) achieved thrombolysis in a significant minority (44%) of patients and might be useful therapy for patients not having access to emergency catheterization.
Heyman's steady-state theory of addiction
Authors: Stuart A. Vyse
Journal: Behavioral and Brain Sciences (1996)

Abstract Heyman's target article contributes to our understanding of addictions by offering solutions to several paradoxes and by recognizing the stable nature of addictive behavior. Previous classical and operant conditioning models have emphasized molecular processes, such as acquisition and extinction, and have failed to address the aggregate effects of long-term exposure to the contingencies of drug and alcohol use.
The role of a computed tomography-based image registered navigation system for natural orifice transluminal endoscopic surgery: a comparative study in a porcine model
Authors: G. Fernández-Esparrach, R. San José Estépar, C. Guarner-Argente, G. Martínez-Pallí, R. Navarro, C. Rodríguez de Miguel, H. Córdova, C. Thompson, A. Lacy, L. Donoso, J. Ayuso-Colella, A. Ginès, M. Pellisé, J. Llach, K. Vosburgh
Journal: Endoscopy (2010)

Background and study aims: Most natural orifice transluminal endoscopic surgery (NOTES) procedures have been performed in animal models through the anterior stomach wall, but this approach does not provide efficient access to all anatomic areas of interest. Moreover, injury of the adjacent structures has been reported when using a blind access. The aim of the current study was to assess the utility of a CT-based (CT: computed tomography) image registered navigation system in identifying safe gastrointestinal access sites for NOTES and identifying intraperitoneal structures.
Analyses of coding region polymorphisms in apical and basolateral human organic anion transporter (OAT) genes [OAT1 (NKT), OAT2, OAT3, OAT4, URAT (RST)] Rapid Communication
Authors: Gang Xu, Vibha Bhatnagar, G.E.N. Wen, Bruce A. Hamilton, Satish A. Eraly, Sanjay K. Nigam
Journal: Kidney International (2005)
The effect of simvastatin on chemotactic capability of SDF-1α and the promotion of bone regeneration
Authors: Yun-Song Liu, Meng-En Ou, Hao Liu, Ming Gu, Long-Wei Lv, Cong Fan, Tong Chen, Xiang-Hui Zhao, Chan-Yuan Jin, Xiao Zhang, Yun Ding, Yong-Sheng Zhou
Journal: Biomaterials (2014)
Case 38-1976
Authors: Richard C. Cabot, Robert E. Scully, James J. Galdabini, Betty U. McNeely, Michael N. Margolies, Austin L. Vickery
Journal: New England Journal of Medicine (1976)

Presentation of CaseA 49-year-old man was admitted to the hospital because of pain in the right lower quadrant of the abdomen.He was well until eight months previously, when he had a brief bout of chills, fever and sweats that were ascribed to "the flu." His symptoms subsided within a few days, and physical examination was negative. Thereafter, he began to experience dull aching in the right lower quadrant with repeated intermittent attacks of sharp pain, particularly during the daytime, associated with bowel movements. Four months before admission a barium-enema examination and a test on the urine for 5-hydroxyindoleacetic . . .
Effects of troglitazone on hepatic and peripheral insulin resistance induced by growth hormone excess in rats
Authors: Miyuki Sugimoto, Noriyuki Takeda, Kazuya Nakashima, Shoji Okumura, Kazuhisa Takami, Kouji Yoshino, Junko Hattori, Masatoshi Ishimori, Rieko Takami, Akihiko Sasaki, Keigo Yasuda
Journal: Metabolism (1998)
Skin Toxicities Compromise Prolonged Pemetrexed Treatment
Authors: Belen Eguia, Anne-Marie Ruppert, Julie Fillon, Armelle Lavolé, Valérie Gounant, Christelle Epaud, Bernard Milleron, Philippe Moguelet, Marie Wislez, Camille Frances, Jacques Cadranel
Journal: Journal of Thoracic Oncology (2011)
Recurrence of Langerhans' cell granulomatosis following lung transplantation
Authors: E Gabbay, J H Dark, T Ashcroft, D Milne, G J Gibson, M Healy, P A Corris
Journal: Thorax (1998)

A case is presented of pulmonary Langerhans' cell granulomatosis which recurred following lung transplantation and responded to cyclophosphamide. This suggests that the primary abnormality in this condition lies in the Langerhans' cell or precursor dendritic cell.
Violence against children is widespread
Authors: John Zarocostas
Journal: BMJ (2006)

A United Nations report on violence against children says that each year more than 50 000 children are killed as a result of homicide. Millions are subjected to physical and psychological abuse, discrimination, neglect, maltreatment, and sexual exploitation.

   ![][1] 

A Chinese child chained by his parents to stop him playing video games

Credit: SIPA/REX

The …

 [1]: /embed/graphic-1.gif
The transdermal inhibition of melanogenesis by a cell-membrane-permeable peptide delivery system based on poly-arginine
Authors: Nanako Ookubo, Hiroyuki Michiue, Mizuki Kitamatsu, Maho Kamamura, Tei-ichi Nishiki, Iori Ohmori, Hideki Matsui
Journal: Biomaterials (2014)
Letter from Europe.
Authors: James B. Herrick
Journal: JAMA (1894)

Prag, Bohemia, May 15, 1894. <h3>To the Editor:</h3> —I have delayed writing until I had become fairly settled and sufficiently acquainted with the methods of work here to be able to give you in a few letters to the Journal, as you requested, some idea of the methods of study in a German University and particularly some idea of what is being done in internal medicine. As I came abroad to do some practical work in pathology and clinical diagnosis, I shall not travel about from place to place to see different men, but shall remain at Prag until the end of the summer semester, the latter part of July. My letters may therefore be lacking in the interest that would come from change of scene and personages. Prag is a wonderful mixture of the old and the new; it is a city of delightful surprises and of strange contrasts.
Dramatic Worsening of Hepatitis C Virus-Related Cryoglobulinemia Subsequent to Treatment With Interferon Alfa
Authors: Jean-Robert Harlé
Journal: JAMA (1995)

To the Editor.  —Interferon alfa is an efficient treatment for mixed cryoglobulinemia related to hepatitis C virus (HCV). We describe a patient whose disease markedly worsened when interferon alfa treatment was started.  Since 1990, a 54-year-old woman had been suffering from cutaneous vasculitis and mixed cryoglobulinemia related to HCV. Between 1990 and 1993, she developed asthenia and arthralgia. In December 1993, results of a liver biopsy showed chronic active hepatitis. On February 7, 1994, a dosage of 3 million U of interferon alfa-2a administered subcutaneously three times per week was started. Twelve hours after the second injection, the patient experienced progressive right leg paresis, and the interferon was stopped after the fifth injection. Between February 20 and 25, numbness and paresthesia in the four limbs occurred, and mononeuritis multiplex affecting the limbs was evident on electrophysiologic study. Results of muscle biopsy showed type II fiber atrophy, and results of nerve
The tsunami and the dangers of goodwill
Authors: Andrew C K Lee
Journal: BMJ (2005)

Following the tsunami in South Asia, there was, as would be expected, the rushing to the scene of a multitude of non-governmental organisations (NGOs), United Nations organisations, and other actors providing emergency relief. There was also a remarkable outpouring of public charity with massive funds being raised for the victims of the disaster. Many volunteers from abroad have independently inundated the afflicted areas. Although notable and well meaning, the public “goodwill” is not without its drawbacks.

In Sri Lanka, where I was dispatched with a relief agency, we found several issues …
Report of an Obstinate Case of Chronic Myelitis, with Accompanying Paralysis of the Lower Half of the Body, Successfully Treated
Authors: C. Taylor
Journal: BMJ (1862)

At that time, he was suffering from equal paralysis of both lower extremities, with obstinate constipation, and incomplete control of the urinary bladder.He had been in this condition eleven months.He was a steady married man, with two chil- dren; and there was no evidence of hereditary taint, gout, syphilis, or lead-poisoning; but he had long suf- fered from various aches and pains, which he termed rheumatic.lie was five feet seven inches in height, moderately strong, and of bilious temperament.The history of the case is briefly as follows.Without any very marked premonitory syroptoms, he experienced one day, when at work in a windowless house, and while exposed to a strong draught, a peculiar tingling sensa- tion in both legs, which soon amounted to numbness, and, in the night, to complete paralysis.He was then seen by a medical gentleman, who, after treating him ORIGINAL COMMUNICATIONS.
Decreased VLDL apoprotein CII/apoprotein CIII ratio may be seen in both normotriglyceridemic and hypertriglyceridemic patients on chronic hemodialysis treatment
Authors: Yasuhisa Wakabayashi, Michihito Okubo, Hajime Shimada, Naoyuki Sato, Asao Koide, Fumiaki Marumo, Haruo Nakamura
Journal: Metabolism (1987)