PROLONGED FUNCTIONAL DEPRESSION OF ANTIDIURETIC MECHANISMS IN PSYCHOGENIC POLYDIPSIA SIMULATING PRIMARY DIABETES INSIPIDUS
Authors: R WEDEEN
Journal: Annals of Internal Medicine (1961)

Case Reports1 April 1961PROLONGED FUNCTIONAL DEPRESSION OF ANTIDIURETIC MECHANISMS IN PSYCHOGENIC POLYDIPSIA SIMULATING PRIMARY DIABETES INSIPIDUSRICHARD WEDEEN, M.D.RICHARD WEDEEN, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-54-4-805 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe differential diagnosis of polyuria and polydipsia is a common problem. Increased renal water loss may occur with: (1) diabetes mellitus, (2) chronic nephritis, (3) severe thyrotoxicosis, (4) kaliopenic nephropathy, (5) hypercalcemia, (6) diabetes insipidus, both primary and nephrogenic, and (7) psychogenic polydipsia. The first five of this group can be differentiated by specific laboratory and clinical studies. There remains, however, the frequently encountered problem of distinguishing primary diabetes insipidus from nephrogenic insipidus and from psychogenic polydipsia.The case herein reported is an example of prolonged functional depression of antidiuretic mechanisms secondary to excessive water intake and simulating primary diabetes...Bibliography1. KourilskyFournier RE: Etude physiopathologique du diabete insipide humain; la forme polyurique. Ann. Méd. 48: 135, 1948. Google Scholar2. CarterRobbins ACJ: The use of hypertonic saline infusions in the differential diagnosis of diabetes insipidus and psychogenic polydipsia. J. Clin. Endocr. 7: 735, 1947. CrossrefGoogle Scholar3. DingmanBenirschkeThorn JFKGA: Studies of the neurohypophyseal function in man. Amer. J. Med. 23: 226, 1957. CrossrefMedlineGoogle Scholar4. WaringKajdiTappan AJLV: A congenital defect of water metabolism. J. Dis. Child. 69: 323, 1945. Google Scholar5. BerlinerDavidson RWDO: Production of hypertonic urine in the absence of pituitary antidiuretic hormone. J. Clin. Invest. 35: 690, 1957. Google Scholar6. CroxattoBarnafiLopezAndrade HLRF: Antidiuretic potency of the blood in diabetes insipidus. Metabolism 3: 32, 1954. MedlineGoogle Scholar7. De WardenerHerxheimer HEA: The effect of high water intake on the kidney's ability to concentrate the urine in man. J. Physiol. 139: 42, 1957. CrossrefMedlineGoogle Scholar8. EpsteinKleemanHendrik FHCRA: The influence of bodily hydration on the renal concentrating process. J. Clin. Invest. 36: 629, 1957. CrossrefMedlineGoogle Scholar9. KleemanMaxwellWitlin CRMMS: Functional isothenuria: an isolated reversible renal tubular defect. Arch. Intern. Med. 101: 1023, 1958. CrossrefGoogle Scholar10. DreifusFrankBellet LSMNS: Determination of osmotic pressure in diabetes insipidus. A new diagnostic test. New Engl. J. Med. 251: 1091, 1954. CrossrefMedlineGoogle Scholar11. Barlowde Wardener EDHE: Compulsive water drinking. Quart. J. Med. 28: 235, 1959. MedlineGoogle Scholar12. Lauson HD: The problem of estimating the rate of secretion of antidiuretic hormone in man. Amer. J. Med. 11: 135, 1951. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: New York, N. Y.*Received for publication March 16, 1960.From the Department of Medicine, Beth Israel Hospital, New York, N. Y.Requests for reprints should be addressed to Richard Wedeen, M.D., 319 Avenue C. New York 9, N. Y. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited bySerum vasopressin (AVP) levels in polyuric brain-dead organ donorsElectroencephalographic Changes in Acute Water IntoxicationPolyuria in Children: Clinical Evaluation and Differential DiagnosisThe Polyuric SyndromesEffects of Water Deprivation in Rats with Polydipsia and Polyuria Due to Long-term Administration of LithiumMIKULICZ'S SYNDROME WITH PERSISTENT HYPOSTHENURIAStörungen der HarnkonzentrierungNephrogenic Diabetes Insipidus Due to Sarcoidosis Without HypercalcemiaFRED PANITZ, JAMES H. SHINABERGERInvestigations into the Thiazide-induced Antidiuresis in Patients with Diabetes InsipidusWATER BALANCE AND THE PITUITARY GLAND: A REVIEW 1 April 1961Volume 54, Issue 4Page: 805-809KeywordsClinical laboratoriesDiabetes mellitusHospital medicineHypercalcemiaNephritisResearch laboratories ePublished: 1 December 2008 Issue Published: 1 April 1961 PDF downloadLoading ...