tbuckley/cabot-search huggingface dataset:
Abstract 19648: Exposure to Ionized Medical Radiation after Heart Transplant is Associated with Higher Risk of Malignancies
Authors: Nir Uriel, Sang-Woo Pak, Kerry Morrison, Arthur R Garan, Melana Yuzefpolskaya, Paolo C Colombo, Susan W Restaino, Andrew Einstein, Hiroo Takayama, Donna M Mancini, Yoshifumi Naka, Ulrich P Jorde
Journal: Circulation (2012)

Objective Evidence on the increase cancer risk due to medical radiation is mounting. Heart transplant (OHT) patients are at high risk for cancer due to immunosuppression medications. In this study we shout to determine the correlation between the cumulative ionized medical radiations after OHT to the development of cancer. Methods: Adult Patients transplanted between 1999-2010 without history of cancer in a large medical center were included in this analysis. Medical tests that expose the patients to radiation (i.e X-ray, Computer Tomography (CT), nuclear test and cardiac catheterization) were collected from the hospital database, and the amount of radiation was calculated based on a look up tables specified for our institution. The prevalence of cancer was recorded from electronical medical records. Results: 891 patients were enrolled to the study. Age 52.3±13.0 years old, 677 (75.9%) were male. The mean follow up time post OHT was 6.9±3.3 years and 76 (8.5%) patients developed de-novo malignancy. Prostate cancer was the most common 20%, followed by lung 17% and hematologic malignancies 13%. The mean time for development of malignancy was 5.2±3.4 years. Patients that developed cancer were exposed to significantly more ionizing radiation 68.0 ± 65.9 mSv vs 54.4 ± 45.9 mSV (p=0.026) respectively. Cumulative radiation exposure was the only variable associated with the development of de-novo cancer in a multivariable regression model (for every increase of 10mSv the chance of cancer increase by 5.1% P=0.046). Patients in the higher tertile of radiation exposure had 40% more chance to develop cancer (Figure). Conclusion High frequency of early post OHT malignancy was reported. There was a strong association between the amounts of medical ionizing radiation to the frequency of post OHT malignancy. This is the first study to report actual cancer percentage in relate to radiation exposure. Minimized the amount of radiation post OHT may reduce the frequency of cancer.
Testosterone and “Age-Related Hypogonadism” — FDA Concerns
Authors: Christine P. Nguyen, Mark S. Hirsch, David Moeny, Suresh Kaul, Mohamed Mohamoud, Hylton V. Joffe
Journal: New England Journal of Medicine (2015)

Despite rampant direct-to-consumer ads regarding "low T" in older men, the Food and Drug Administration has concluded that the available evidence does not support an indication for testosterone therapy for "age-related hypogonadism."
Corrected QT Variability in Serial Electrocardiograms in Long QT Syndrome
Authors: Ilan Goldenberg, Jehu Mathew, Arthur J. Moss, Scott McNitt, Derick R. Peterson, Wojciech Zareba, Jesaia Benhorin, Li Zhang, G. Michael Vincent, Mark L. Andrews, Jennifer L. Robinson, Brian Morray
Journal: Journal of the American College of Cardiology (2006)
A Multicenter Randomized Noninferiority Trial Comparing GreenLight-XPS Laser Vaporization of the Prostate and Transurethral Resection of the Prostate for the Treatment of Benign Prostatic Obstruction: Two-yr Outcomes of the GOLIATH Study
Authors: James A. Thomas, Andrea Tubaro, Neil Barber, Frank d’Ancona, Gordon Muir, Ulrich Witzsch, Marc-Oliver Grimm, Joan Benejam, Jens-Uwe Stolzenburg, Antony Riddick, Sascha Pahernik, Herman Roelink, Filip Ameye, Christian Saussine, Franck Bruyère, Wolfgang Loidl, Tim Larner, Nirjan-Kumar Gogoi, Richard Hindley, Rolf Muschter, Andrew Thorpe, Nitin Shrotri, Stuart Graham, Moritz Hamann, Kurt Miller, Martin Schostak, Carlos Capitán, Helmut Knispel, Alexander Bachmann
Journal: European Urology (2015)
Lullaby
Authors: Hedy S Wald
Journal: JAMA (2010)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Abstract 5795: Impact of the Modified Henry Ford Warfarin Maintenance Dosing Algorithm on Quality of Anticoagulation at a Specialist Anticoagulation Clinic
Authors: Robby Nieuwlaat, Yang-Ki Kim, Stuart J Connolly, Sam Schulman, Jack Hirsh, Karina Meijer, Nina Raju, Scott Kaatz, John W Eikelboom
Journal: Circulation (2009)

Purpose: The efficacy of warfarin depends on the time that the international normalized ratio (INR) is in the target therapeutic range. The time-in-therapeutic range (TTR) is a measure of anticoagulation quality, and should be maximized. The objective of our before-after study was to determine whether routine use of a simple manual warfarin dosing algorithm compared with ‘expertise-based’ dosing can improve the TTR for warfarin. Methods: The study was performed at a single anticoagulation clinic in Hamilton, Canada. In the ‘before’ phase (August, 2006 until September, 2007) we retrospectively calculated in patients on warfarin: agreement between warfarin dosing and the modified Henry Ford dosing algorithm and TTR, using Rosendaal’s linear interpolation method. In this period, warfarin was managed by experienced anticoagulation clinic physicians. In the ‘after’ phase (July until December, 2008) we prospectively calculated the same parameters. Differences between ‘before’ and ‘after’ were tested with the independent t-test for continuous and chi-square for dichotomous variables. Results: We included 873 patients in the ‘before’ phase and 1,088 patients in the ‘after’ phase. Before introduction of the algorithm, 71% of warfarin dose adjustments were consistent with the algorithm in patients targeting an INR of 2–3 and 56% for those targeting INR 2.5–3.5, whereas after algorithm introduction agreement increased to 90% and 81%, respectively. Introduction of the dosing algorithm significantly increased the TTR in patients targeting an INR of 2–3 from 67.2% to 73.2% (p&lt;0.001) and in those targeting an INR of 2.5–3.5 from 49.8% to 63.8% (p&lt;0.001). This improvement of TTR was due to a decreased proportion of subtherapeutic INRs, from 18 to 13% (p&lt;0.01) with target INR 2–3 and from 41 to 25% (p&lt;0.01) with target INR 2.5–3.5, while the proportion of supratherapeutic INRs did not significantly change. Conclusion: Introduction of the modified Henry Ford manual warfarin maintenance dosing algorithm in place of expertise-based dosing significantly improved the mean TTR in our tertiary care anticoagulation clinic. This widely applicable algorithm could be an inexpensive evidence-based method to improve warfarin control and thereby patient outcomes.
Stricture of the OEsophagus
Authors: R. Batty
Journal: BMJ (1859)

part, but when a serous cavity intervenes, and widely separates the vascular plexuses of the cutaneous surface and the subja- cenit mucous.It is beyond all question that leeches to the epigastrium relieve an inflamed gastric membrane; but surely no one will imagine that this relief depends on any -witlhdrawal of blood from the engorged gastric capillaries.General bleeding lay be of service, if the heart's action, as evidencedi by a firm pulse, is over-powerful; but it is of no much avail as a tissue-sedative alone.In some instances, we have drus wlhich exert a decided sedative action on the in.flameed membrane.In inflammation of the air-passages, anti- mony or ipecacuan; in enteric catarrh, hydrargyrum cum cretit anid Dover's powder; in dysentery, ipecacuan; in ton- sillitis, ani cmetic,-are all means of well proved efficacy.It
Occupational Hydrofluoric Acid Injury from Car and Truck Washing — Washington State, 2001–2013
Authors: Carolyn K. Reeb-Whitaker, Carly M. Eckert, Naomi J. Anderson, David K. Bonauto
Journal: MMWR Morbidity and Mortality Weekly Report (2015)

Exposure to hydrofluoric acid (HF) causes corrosive chemical burns and potentially fatal systemic toxicity. Car and truck wash cleaning products, rust removers, and aluminum brighteners often contain HF because it is efficient in breaking down roadway matter. The death of a truck wash worker from ingestion of an HF-based wash product and 48 occupational HF burn cases associated with car and truck washing in Washington State during 2001-2013 are summarized in this report. Among seven hospitalized workers, two required surgery, and all but one worker returned to the job. Among 48 injured workers, job titles were primarily auto detailer, car wash worker, truck wash worker, and truck driver. Because HF exposure can result in potentially severe health outcomes, efforts to identify less hazardous alternatives to HF-based industrial wash products are warranted.
Comparison of the Pharmacokinetics and Pharmacodynamics of LY2963016 Insulin Glargine and EU- and US-Approved Versions of Lantus Insulin Glargine in Healthy Subjects: Three Randomized Euglycemic Clamp Studies
Authors: Helle Linnebjerg, Eric Chen Quin Lam, Mary E. Seger, David Coutant, Laiyi Chua, Chew Lan Chong, Maria M. Ferreira, Danny Soon, Xin Zhang
Journal: Diabetes Care (2015)

OBJECTIVE LY2963016 (LY IGlar) and Lantus (IGlar) are insulin glargine products manufactured by distinct processes but with identical amino acid sequences. Three studies evaluated the pharmacokinetic (PK) and pharmacodynamic (PD) similarity of LY IGlar and the European Union– and US-approved versions of IGlar. RESEARCH DESIGN AND METHODS These were three single-site, randomized, double-blind, two-treatment, four-period, crossover, euglycemic clamp studies. In each study, fasted healthy subjects received 0.5 units/kg s.c. doses of two different insulin glargine products on two occasions each, following a randomized sequence. A ≥7-day washout period separated the doses. Blood samples were collected predose and up to 24 h postdose to assess PK; PD was assessed by a euglycemic clamp lasting up to 24 h. RESULTS A total of 211 subjects participated in the three studies. The PK (area under the curve [AUC]; maximum observed concentration [Cmax]) and PD (maximum glucose infusion rate [Rmax]; total glucose infusion during the clamp [Gtot]) were similar between LY IGlar and IGlar, with the ratios of geometric means ranging from 0.90 to 0.95 for PK parameters and from 0.91 to 0.99 for PD parameters across studies. In all cases, the 90% CIs for the ratios of geometric means were completely contained in the prespecified acceptance limits of 0.80–1.25. Adverse events were similar between treatments. CONCLUSIONS These studies demonstrated that the PK and PD properties of LY IGlar and IGlar were similar after single 0.5 units/kg s.c. doses in healthy subjects, contributing to the totality of evidence supporting similarity of these products.
Abstract 11146: Coronary Artery Negative Remodeling and Intimal Thickening Predict Long-Term Clinical Outcomes After Heart Transplantation
Authors: Kozo Okada, Hideki Kitahara, Hyoung-Mo Yang, Hong-Seok Lim, Kyuhachi Otagiri, Shigemitsu Tanaka, Yuhei Kobayashi, Paul G Yock, Alan C Yeung, Peter J Fitzgerald, Kiran K Khush, Yasuhiro Honda, William F Fearon
Journal: Circulation (2014)

Introduction: Heart transplant studies have primarily focused on coronary artery intimal thickening to assess severity of cardiac allograft vasculopathy. More recently, negative vessel remodeling has been recognized as another important measure. This study aimed to investigate the association between early vessel remodeling and clinical prognosis after heart transplantation.

Methods: In 99 recipients of heart transplants, baseline (4-6 weeks post-transplant) and 1-year volumetric intravascular ultrasound (IVUS) was performed in the first 50 mm of the left anterior descending coronary artery. In categorical analysis, significant intimal thickening and vessel remodeling were defined using the median value of the volume change. Acute cellular rejection was determined by endomyocardial biopsy as ISHLT Grade ≥2R. Clinical outcomes were followed for a median of 5.2 years, and late major adverse events were defined as death or re-transplantation after the first year.

Results: During the first year after transplant, 30.4% of patients experienced one or more episodes of acute cellular rejection. Patients with acute rejection showed significantly greater intimal thickening (Δintimal volume), whereas vessel remodeling (Δvessel volume) did not differ between patients with or without acute rejection. After 1 year, adverse events occurred in 28.5% of patients, and were significantly associated with vessel shrinkage during the first year. Kaplan-Meier analysis demonstrated the lowest long-term event-free survival in patients with both vessel shrinkage and intimal thickening detected at 1-year post-transplant.

Conclusions: In this population, negative vessel remodeling was the primary determinant of long-term mortality or re-transplantation. Combined assessment of both vessel remodeling and intimal thickening enhances the prognostic value of IVUS by identifying high-risk patients who may benefit from close follow-up and targeted medical therapies.

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Nitrone anti-cancer activity in Apcmin/+ model of colon cancer
Authors: Robert Floyd, Rheal Towner, Dee Wu, Wei-Xing Guo, Steven Foster, Mark Huycke
Journal: Cancer Research (2008)

2324   We examined the anti-cancer activity of the nitrone α-phenyl-tert-butyl nitrone (PBN) in the  APC  min/+  model of colon cancer. PBN as well as its metabolite 4-hydroxy-PBN (4-OHPBN) was administered in drinking water to the mice starting at age day 21 and continued throughout. Tumor development in three groups of 15-20 mice each were examined using gadolinium probe enhanced magnetic resonance imaging (MRI) taken 4 times (7,12,16 and 18 weeks) during tumor development. At the time of experiment termination pathologic data of tumor size and number was done. The MRI results showed that in the non-treated mice there was a time-dependent increase in tumor number and size, but the PBN-treated mice showed a time-dependent significant decrease in tumor volume and number throughout the treatment period. 4-OHPBN showed no anti-cancer activity in this study because it had limited water solubility. The final pathologic data was in agreement with the MRI data. Human colon cancer cells (HCT-116) were used to determine if PBN interfered with oxaliplatin killing of these cells. The results showed that PBN when added up to 2 mM and incubated with 0-20 μM oxaliplatin for up to 48 hours caused at most a 4-5% decrease in oxaliplatin killing. The amount of active fraction caspase 3 present in the oxaliplatin treated cells showed little difference between PBN treated and non-treated cells. We previously showed PBN had anti-cancer activity in the rat choline deficient model of hepatocellular carcinoma and the rat C6 cell orthotopic model of glioblastoma and now in the  APC  min/+  model. Research was supported in part by OARS grant AR052-041 and NIH RO1CA82506, OCAST fMRI.002 and Department of Veterans Affairs Merit Review Program and Frances Duffy Endowment.
Disseminating Health Care InnovationDisseminating Health Care Innovation
Authors: Ziad E. Deeb, Todd D. Otteson
Journal: JAMA (2003)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Abstract 16366: FDG PET Myocardial Metabolism Differentiates Electrophysiological Voltage Scar, Border Zone and Healthy Points in Patients Undergoing Ischemic Ventricular Tachycardia Ablation
Authors: Jing Tian, Mark Smith, Ghada Ahmad, Ameer Abutaleb, Alejandro Jimenez, Anastasios Saliaris, Vincent See, Steve Shorofsky, Vasken Dilsizian, Timm Dickfeld
Journal: Circulation (2011)

Introduction: Left ventricular (LV) scar and border zone (BZ) have been implicated in the arrhythmogenesis of ventricular tachycardia (VT). Assessment of myocardial viability with SPECT and PET for...
A Clinical and Immunological Study of Allergy to Hen's Egg White
Authors: Tor Langeland
Journal: Allergy (1983)

The occurrence of proteins cross‐reacting with allergens in hen's egg white was studied in turkey, duck, goose and seagull egg whites, in hen egg yolk, and in hen and chicken sera and flesh. The study was based upon quantitative immunoelectrophoretic techniques. The different egg whites were all found to contain proteins cross‐reacting with most of the allergens in hen's egg white, but the degree of cross‐reactivity varied considerably among the various egg whites. All egg whites contained proteins able to bind human IgE‐antibody in the sera of patients with allergy to hen's egg white. Several proteins cross‐reacting with allergens in hen's egg white were also detected in egg yolk and in hen and chicken sera and flesh. Clinical implications of the results are discussed.
ZNF521 Is a Zinc Finger Protein That Prevents Differentiation Of Human MLL-AF9-Positive Myeloid Leukemic Cells
Authors: Giulia Morello, Sanja Aveic, Sonia Minuzzo, Barbara Michielotto, Silvia Bresolin, Chiara Frasson, Martina Pigazzi, Stefano Indraccolo, Giuseppe Basso, Giuseppe Germano
Journal: Blood (2013)
Abstract 1641: Altered Hemoglobin is Associated with High Density Lipoproteins in Sera from Mice Fed Atherogenic/Hyperlipidemic Diets
Authors: Srinivasa T Reddy, Junji Watanabe, Katherine J Chou, James C Liao, Julian Whitelegge, Robin Farias-Eisner, Mohamad Navab, Alan M Fogelman
Journal: Circulation (2006)
Abstract 20240: CD-NP, a Novel Dual Guanylyl Cyclase Receptor Activator, Decreases Fibrosis and Improves Diastolic Dysfunction Produced by Mild Renal Insufficiency
Authors: Fernando L Martin, Tomoko Ichiki, Brenda K Huntley, Paul M McKie, S J Sangaralingham, Josef Korinek, Gerald E Harders, Horng H Chen, John C Burnett
Journal: Circulation (2010)

Reduced renal function increases cardiovascular (CV) morbidity and mortality. We have reported that mild reduction in renal function produced by unilateral nephrectomy (UNX) increases myocardial collagen content resulting in myocardial diastolic impairment in the absence of hypertension. Natriuretic peptides (NPs) possess cardiorenal protective properties via activation of particulate guanylyl cyclase (GC) receptors. We hypothesized that in this model of mild renal dysfunction, that a novel Mayo designed chimeric NP, CD-NP, would prevent cardiac remodeling, diastolic impairment, suppress aldosterone (Aldo) and preserve renal function. CD-NP represents the first dual GC receptor agonist which has anti-fibrotic via GC-B, aldosterone suppressing and renopreserving properties via GC-A without excessive hypotension. Methods: Cardiorenal function and structure were assessed in Wistar rats (UNX;n=9) and (CD-NP UNX;n=9) 4 weeks (wk) after UNX. At wk 4 GFR, Na, water excretion, and Aldo were assessed. LV mass, EF,...
Abstract 2870: In Women without Obstructive Coronary Artery Disease, Endothelial-Dependent and Non-Endothelial Dependent Coronary Reactivity Dysfunction are Associated with Different Types of Adverse Outcomes. The NHLBI Women’s Ischemia Syndrome Evaluation (WISE).
Authors: Scott Midwall, R. David Anderson, Delia Johnson, Eileen Handberg, Rhonda Cooper-Dehoff, Karen Smith, Carl Pepine
Journal: Circulation (2007)

Backround: Altered coronary reactivity frequently occurs in women with chest discomfort both with and without obstructive coronary artery disease (CAD). Among those with obstructive CAD, the endothelial-dependent and non-endothelial dependent components of this altered reactivity have been associated with adverse outcomes. The clinical events among those with altered coronary reactivity but without obstructive CAD are not well defined. Methods: We evaluated 169 women with suspected myocardial ischemia who had no obstructive CAD at coronary angiography. Coronary reactivity was assessed by measuring flow reserve (CFR) with adenosine (endothelial-dependent) and change in vessel diameter (DIAM) following acetylcholine (non-endothelial dependent). Women were then followed for major adverse events (death, myocardial infarction, stroke, or hospitalization for heart failure) as well as hospitalization for recurrent angina by annual telephone contact over a median of 6.0 years. Results: Mean age was 54 ± 10 years, 15% were non-white, 37% had abnormal CFR (&lt;2.32), and 47% had abnormal DIAM (no change or constriction). Of the women receiving both coronary reactivity tests, results were concordant in only 52%. Major events occurred in 16% (28/169) of which 5% (8/169) died. An additional 24% (41/169) were hospitalized for worsening angina. Major adverse events were predicted by abnormal CFR (27% vs 10%, p = 0.006) but not abnormal DIAM, while abnormal DIAM, but not CFR, predicted hospitalization for angina. Conclusion: Endothelial-dependent and non-dependent coronary dysfunction coexist in approximately one-half of women tested without angiographic evidence of CAD and appear to predict different types of adverse outcomes during follow-up. These results should foster developement of new diagnostic and treatment strategies targeting both endothelial and non-endothelial (e.g. vascular smooth muscle) dependent coronary dysfunction in women.
Abstract 16563: Importance of Exercise Capacity in Predicting Impact of Delaying Surgical Correction in Significant Degenerative Mitral Regurgitation
Authors: Peyman Naji, Fadi Asfahan, Tyler Barr, A Marc Gillinov, Richard A Grimm, L Leonardo Rodriguez, Tomislav Mihaljevic, Brian P Griffin, Milind Y Desai
Journal: Circulation (2013)

Background: In degenerative mitral regurgitation (DMR), exercise echocardiography (ExEc) aids in symptom evaluation & timing of mitral valve (MV) surgery. In patients with ≥3+ DMR undergoing MV sur...