OCULO-ORO-GENITAL SYNDROME: A DEFICIENCY DISEASE
Authors: Eugene C. Jacobs
Journal: Annals of Internal Medicine (1951)

Article1 November 1951OCULO-ORO-GENITAL SYNDROME: A DEFICIENCY DISEASEEUGENE C. JACOBSEUGENE C. JACOBSSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-35-5-1049 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptI. INTRODUCTIONSince Gasper Casal first described "mal de rosa" some 200 years ago, many observers have noted that pellagra has varied considerably in its clinical manifestations. The variations of pellagra have received many designations: mild pellagra, pellagroid, pseudopellagra, pellagra sine pellagra, ariboflavinosis, hyporiboflavinosis, riboflavin deficiency disease, oro-genital syndrome and oculo-oro-genital syndrome.1-11 Although these terms are confusing, they represent progress in the separation and classification of the various component deficiencies of the vitamin B complex.Thirty-eight months of incarceration in several Japanese prisoner-of-war camps revealed that deficiency diseases run a gamut in a fairly regular order during protracted dietary restriction....Bibliography1. Wood EJ: A treatise on pellagra, 1912, D. Appleton Co., New York. Google Scholar2. Stannus HS: Pellagra in Nyasaland, Tr. Roy. Soc. Trop. Med. and Hyg. 7: 32, 1913. CrossrefGoogle Scholar3. Crosby CE: Pellagra with erythema of the scrotum as initial manifestation, J. A. M. A. 68: 1403, 1917. CrossrefGoogle Scholar4. GoldbergerWheeler JGA: Experimental pellagra in white male convicts, Arch. Int. Med. 25: 451-471, 1920. CrossrefGoogle Scholar5. LanderPallister JVRA: Avitaminosis B2 , Tr. Roy. Soc. Trop. Med. and Hyg. 29: 121-134, 1935. CrossrefGoogle Scholar6. Mitra K: Oro-genital syndrome, Indian M. Gaz. 78: 330, 1943. MedlineGoogle Scholar7. Fehily L: Deficiency diseases in reoccupied Hong Kong, Brit. M. J. 1: 220, 1947. CrossrefMedlineGoogle Scholar8. Burgess RC: Deficiency diseases in prisoners-of-war at Changi, Singapore, Lancet 251: 411-418, 1946. CrossrefGoogle Scholar9. Stannus HS: Some problems in riboflavin and allied deficiencies, Parts I and II, Brit. M. J. 2: 103-105, and 140-144, 1944. CrossrefMedlineGoogle Scholar10. Denny-Brown D: Neurological conditions resulting from prolonged and severe dietary restrictions, Medicine 26: 41-113, 1947. CrossrefMedlineGoogle Scholar11. Frankland AW: Deficiency scrotal dermatitis, Brit. M. J. 2: 1023-1026, 1948. CrossrefMedlineGoogle Scholar12. Page JA: Painful feet syndrome among prisoners-of-war in Far East, Brit. M. J. 2: 260-262, 1946. CrossrefGoogle Scholar13. Cruickshank EK: Painful feet syndrome among prisoners of war in Far East, Lancet 2: 369-372, 1946. CrossrefMedlineGoogle Scholar14. Lewis RB: Painful feet in American prisoners-of-war, U. S. Armed Forces M. J. 1: 146-157, 1950. MedlineGoogle Scholar15. BloomMergTaylor SMEHWW: Nutritional amblyopia in American prisoners, Am. J. Ophth. 29: 1248-1257, 1946. CrossrefMedlineGoogle Scholar16. Musselman MM: Nutritional diseases in Cabanatuan prison camp, War Med. 8: 325-332, 1945. Google Scholar17. Katz CJ: Neuropathologic manifestations found in Japanese Prison Camp, J. Nerv. and Ment. Dis. 103: 456-465, 1946. CrossrefMedlineGoogle Scholar18. Jacobs EC: Effects of starvation on sex hormones in the male, J. Clin. Endocrinol. 8: 227-232, 1948. CrossrefGoogle Scholar19. Jacobs EC: Gynecomastia following severe starvation, Ann. Int. Med. 28: 792-797, 1948. LinkGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: *Received for publication October 20, 1950. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byOral Signs of Nutritional DiseaseOral Manifestations of Hematologic and Nutritional DiseasesSkin and mucosal manifestations in vitamin deficiencyGlucagonoma syndromeErkrankungen des Auges im KindesalterErnährungskrankheiten 1 November 1951Volume 35, Issue 5Page: 1049-1054KeywordsB vitaminsCyclic adenosine monophosphateRiboflavin ePublished: 1 December 2008 Issue Published: 1 November 1951 PDF downloadLoading ...