tbuckley/cabot-search huggingface dataset:
MicroRNA Expression in Cytogenetically Normal Acute Myeloid Leukemia
Authors: Guido Marcucci, Michael D. Radmacher, Kati Maharry, Krzysztof Mrózek, Amy S. Ruppert, Peter Paschka, Tamara Vukosavljevic, Susan P. Whitman, Claudia D. Baldus, Christian Langer, Chang Gong Liu, Andrew J. Carroll, Bayard L. Powell, Ramiro Garzon, Carlo M. Croce, Jonathan E. Kolitz, Michael A. Caligiuri, Richard A. Larson, Clara D. Bloomfield
Journal: New England Journal of Medicine (2008)

A microRNA signature in molecularly defined
Soluble CXCL16 Predicts Long-Term Mortality in Acute Coronary Syndromes
Authors: Anna M. Jansson, Pål Aukrust, Thor Ueland, Camilla Smith, Torbjørn Omland, Marianne Hartford, Kenneth Caidahl
Journal: Circulation (2009)

Background— CXCL16/SR-PSOX is an interferon-γ–regulated chemokine and scavenger receptor for oxidized low-density lipoprotein that is expressed in atherosclerotic lesions. Proteolytic cleavage of membrane-bound CXCL16 releases soluble CXCL16, which may promote migration of effector T cells and augment a proatherogenic inflammatory response. We hypothesized that soluble CXCL16 concentrations are associated with long-term outcome in patients with acute coronary syndromes. Methods and Results— We assessed the association between circulating CXCL16 levels obtained within 24 hours after admission and time to death in 1351 patients (median age 67 years, 30% female) with a diagnosis of unstable angina, non–ST-segment–elevation myocardial infarction, or ST-segment–elevation myocardial infarction. During a median follow-up time of 81 months, 377 patients died. Increased levels of CXCL16 were prognostically unfavorable; the fourth versus first quartile was associated with higher risk of death (hazard ratio 2.1; 95% CI 1.6 to 2.8; P &lt;0.0001), triple risk of developing heart failure (hazard ratio 3.0; 95% CI 1.8 to 5.1; P &lt;0.0001), and a doubling of the risk of rehospitalization for myocardial infarction (hazard ratio 2.1; 95% CI 1.3 to 3.3; P =0.002). After adjustment for conventional risk markers, logarithmically transformed CXCL16 level remained a strong independent indicator of long-term mortality (hazard ratio 1.21; 95% CI 1.09 to 1.36 per 1 SD increase in CXCL16; P =0.0006) and congestive heart failure development (hazard ratio 1.25; 95% CI 1.05 to 1.48; P =0.01). In a subsample of 714 patients, after further adjustment for troponin T, high-sensitive C-reactive protein, pro–B-type natriuretic peptide, and left ventricular ejection fraction, CXCL16 still provided significant additional prognostic information on mortality (hazard ratio 1.21; 95% CI 1.02 to 1.42 per 1 SD increase in CXCL16; P =0.02). Conclusions— In patients with an acute coronary syndrome, CXCL16 levels obtained within 24 hours of admission are associated with long-term mortality after adjustment for other risk factors.
Balanced Nutrition: Beyond the Cholesterol Scare
Authors: Stanley M. Garn
Journal: JAMA (1990)

Most popular "diet" books are written by free-lancers who bait their literary fare with breathless revelations, lists of allegedly healthy foods, dietary approaches to near-immortality, and a sprinkling of misinformation. However, Stare, Olson, and Whelan, who qualify as both accomplished writers and nutrition professionals, take on a very different task, aiming to provide a basic knowledge of human nutrition in an easily read, large-type format, complete with a glossary and an index. They deal with the question of vitamin supplements (of which they properly disapprove), fad diets, and inevitably cholesterol intake and coronary heart disease, which gives this book its subtitle. Stare, Olson, and Whelan take a pessimistic position on lowering cholesterol by dietary restriction as a means to reduce atherosclerosis and associated vascular diseases. They are also far less than enthusiastic about the "prudent" diet and the suggestions made by the American Heart Association. With these exceptions, the suggestions
Pregnancy and Hodgkin's Disease
Authors: DANIEL J. MAZANEC
Journal: Annals of Internal Medicine (1982)

Letters and Corrections1 April 1982Pregnancy and Hodgkin's DiseaseDANIEL J. MAZANEC, M.D.DANIEL J. MAZANEC, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-96-4-531 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: Jacobs and colleagues (1) have addressed an important clinical problem in their study on management of the pregnant woman with Hodgkin's disease. Treatment directed at maintaining a high likelihood of cure while protecting the fetus is, as they indicate, the critical objective. However, their recommendation of therapeutic abortion for patients in the first trimester or first half of second trimester (20 weeks), except those with stage IA nonbulky neck or axillary disease, is not supported by their data or literature review. Moreover, this therapy obviously fails to achieve the second aspect of the treatment objective—protection of the...Reference1. JACOBS C, DONALDSON S, ROSENBERG S, and KAPLAN H. Management of the pregnant patient with Hodgkin's disease. Ann Intern Med 1981;95:669-75. LinkGoogle Scholar1. JACOBS C, DONALDSON S, ROSENBERG S, and KAPLAN H. Management of the pregnant patient with Hodgkin's Disease. Ann Intern Med. 1981;95:669-75. LinkGoogle Scholar2. HELLMAN L and PRICHARD J. Williams Obstetrics. 14th ed. New York: Appleton-Century-Crofts; 1970:1063. Google Scholar1. ROSENBERG S. The clinical evaluation and staging of patients with malignant lymphoma. Recent Rev Cancer Res. 1971;36:32-42. CrossrefGoogle Scholar2. HOPPE R. Radiation therapy in the treatment of Hodgkin's disease. Semin Oncol. 1980;7:144-54. MedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: DANIEL J. MAZANEC, M.D.Affiliations: Cleveland Clinic Foundation Cleveland, OH 44106 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 April 1982Volume 96, Issue 4 Page: 531-532 Keywords Fetuses Hodgkin lymphoma Pregnancy ePublished: 1 December 2008 Issue Published: 1 April 1982 PDF downloadLoading ...
Correction: Intravenous Verapamil and Multifocal Atrial Tachycardia
Authors: CHARLES Y. LUI
Journal: Annals of Internal Medicine (1988)

Letters and Corrections1 June 1988Correction: Intravenous Verapamil and Multifocal Atrial TachycardiaCHARLES Y. LUI, M.SC., M.D.CHARLES Y. LUI, M.SC., M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-108-6-914 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptIn the letter by Lui and Franchina (1) in the March issue, the word "not" was omitted in the sixth sentence of the last paragraph. This sentence should read: "It is of interest to note that in the study of Aronow and associates. . . the patient who was restored to sinus rhythm was not on digoxin, whereas 3 of the 4 who did not convert were receiving digoxin at the time of study."...Reference1. LUI C and FRANCHINA J. Verapamil and multifocal atrial tachycardia [Letter]. Ann Intern Med. 1988;108:485-6. LinkGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: CHARLES Y. LUI, M.SC., M.D.Affiliations: Salem Veterans Administration Medical Center Salem, VA 24153 University of Virginia, Charlottesville VA 22908 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 June 1988Volume 108, Issue 6Page: 914-914KeywordsTachycardia ePublished: 1 December 2008 Issue Published: 1 June 1988 PDF downloadLoading ...
Gastric Emptying Patterns in Kaposiʼs Sarcoma and Gastroenteritis Secondary to Human Immunodeficiency Virus Infection
Authors: H. T. TUROGLU, H. M. ABDEL-DAYEM, C. BONANNO
Journal: Clinical Nuclear Medicine (1994)

The study included 11 patients with AIDS who underwent gastric emptying studies for solid food, endoscopy (esophagogastroduodenoscopy), and gastric biopsy whenever gastritis was diagnosed on endoscopy. All studies were performed within 1 week. The studies were retrospectively reviewed to analyze the changes in gastric emptying secondary to Kaposi's sarcoma (KS) with or without opportunistic infections. Two patients with KS only had rapid gastric emptying (T1/2 6.7 and 45 minutes). Two other patients with KS and opportunistic infections had normal gastric emptying (T1/2 56.7 and 70 minutes), and one patient with KS and opportunistic infections had rapid gastric emptying (T1/2 25.9 minutes). Four patients with gastritis secondary to opportunistic infections and no KS had delayed gastric emptying (T1/2 622, 92, 266.5, and 179.4 minutes). The remaining two patients had endoscopy showing gastritis not proven by biopsy, and both had rapid gastric emptying. One patient had gastric ulcer (T1/2 39 minutes), and the other had chronic active hepatitis and early cirrhosis (T1/2 15 minutes). Esophagitis was present in 6 out of 7 patients who had gastritis. Esophageal candidiasis was confirmed in three patients, and cytomegalovirus was confirmed in one patient. The findings suggest that gastroduodenal KS is associated with fast gastric emptying in patients with AIDS. However, normal gastric emptying study does not reflect normal gastric physiology in patients with AIDS.
New HIV diagnoses in UK continue to decline
Authors: J. Wise
Journal: BMJ (2014)

The number of people with a new HIV diagnosis in the United Kingdom has slightly declined over the past year, although it increased among young gay men and the over 50s, figures from Public Health England have shown.1

New HIV diagnoses in 2013 numbered 6000, down from 6245 in 2012. New diagnoses have continued to decline since they peaked at 7892 in 2005, largely due to a fall in people infected abroad.

The latest statistics showed that the number of people receiving HIV care in 2013 …
She has " Suffered Many Things of Many Physicians."
Authors: A. L. Cory
Journal: JAMA (1896)

Chicago, Ill., March 14, 1896. <h3>To the Editor:</h3> —A lady recently referred to me for urinalysis and examination of the sputum gives the following history: She has had an operation for the repair of a lacerated perineum and uterine cervix, also afterward had abdominal hysterectomy; a prominent medical man of the city says she has Graves' disease. She has mitral insufficiency, urinalysis shows the urine loaded with albumin waxy, granular and epithelial casts, showing she is well advanced in chronic interstitial nephritis, and the sputa is abundantly mixed with tubercle bacilli. Is there anything more she can have? Yours truly, 4101 State Street.
Thrombocytopenia During Infectious Diseases
Authors: Hobart A. Reimann
Journal: JAMA (1966)

<h3>To the Editor:—</h3> Editorial comment (<b>195</b>:680, 1966) calls attention to thrombocytopenia as a feature of gram-negative bacteremic infections. Numerous recent papers have emphasized thrombocytopenia as peculiar to dengue, mumps, rubella, and infectious mononucleosis as if it were something new (<i>Postgrad Med J</i><b>41</b>:1965, 542). Hayem (<i>C R Acad Sci</i><b>96</b>:653,1883), however, recorded thrombocytopenia during the acute stages of most infectious diseases and transient thrombocytosis after recovery. The same was described in lobar pneumonia (<i>J Exp Med</i><b>40</b>:533, 1924), in typhus (<i>Arch Path</i><b>7</b>:640, 1929) and in many other coccal, bacillary, viral, protozoal, and metazoal diseases (<i>Medicine</i><b>17</b>:155, 1938). Evidently, as pointed out 83 years ago, transient thrombocytopenia is a feature of most or all acute infectious diseases.
Superannuation and Substandard Lives
Authors: A. J. Steeds
Journal: BMJ (1971)

better qualifications as "they should have a true knowledge of the type of life ahead."Many students whose parents are doctors enter the profession after some gentle per- suasion to follow in father's footsteps, rather than genuinely desiring to become medical practitioners.Their knowledge in these cir- cumstances is hardly likely to promote a "sense of vocation and kindness."Those who join medicine without such compelling in- fluences are more likely to have a vocation.For too long the medical profession barred many for reasons other than academic attainment.The change in attitude in recent years is a most welcome one.-Iam, etc.,
Interference of a propranolol metabolite with serum bilirubin estimation in chronic renal failure.
Authors: S al-Damluji, J H Meek
Journal: BMJ (1980)

pressure is tiring and can be given only periodically.It offers a useful alternative to continuous mechanical ventilation plus positive end expiratory pressure when treatment is prolonged and the patient can breathe spontaneously.4There are few reports on the use of continuous positive airway pressure in adults, but our case shows that it may be an alternative to continuous mechanical ventilation plus positive end expiratory pressure in treating the adult respiratory distress syndrome.
ACTION OF THE GOLDEN BELT DISTRICT MEDICAL SOCIETY OF KANSAS.
Authors: Eric E. Sattler
Journal: JAMA (1891)

<h3>To the Editor:</h3> —While in favor of Chicago, as the publishing centre forThe Journal, I think the better plan, in view of the present controversy, would be to<i>abolish</i>The Journal<i>altogether</i>. It has never supplied a want in medical journalism, and it can never be a universal success, because it cannot unite and harmonize the varied and various interests of this immense breadth of country. Comparisons with the<i>British Medical Journal</i>, so often made in these columns, are entirely illogical when we take in consideration the small area of England, and the difference in the character of the medical profession in the two countries. There are plentyof medical journals in this country to-day which would publish the papers that are read at our meetings to much greater advantage to their authors, and much sooner, thanThe Journalcan or has done. I am in favor of abolishingThe
The foul taste of medicine
Authors: Theodore Dalrymple
Journal: BMJ (2007)

I was one of the many middle class children whose tonsils were sacrificed to the need of ear, nose, and throat surgeons to increase their incomes. I am not in the least bitter about it because of the ice cream I was given to eat after the operation, though I did dive down to the bottom of the bed and spit out the foul tasting medicine I was also given. The ward sister rebuked me sternly for my bad behaviour, but I had my revenge when my mother gave me a box of chocolate letters that I distributed to all the staff with the conspicuous exception of her.

Medicine has always tasted foul, of …
The Thomas Vicary Lecture ON THE SURGICAL TRADITION: Delivered in the Royal College of Surgeons of England on December 3rd, 1919
Authors: J. Tweedy
Journal: BMJ (1919)

IN thie year 1646 Mr. Edward Arris, a mernber of the Company of Barbers and Surgeons, paid to the Company tlle sum of £300 for the use of the New Publique Anatomy."This sum was subsequently repaid to Mr. Arris, and in lieu thereof lhe settled upon tlhe Company an annuity of £30, whiclh shortly before hiis deatlh lhe redeemed by the payment of £510.Nine years later Mr. Jolhn Gale, a member of the Company, left to the Com- pany an annuity of £16
754-4 Proven Efficacy of Repeated Dose Intravenous Ibutilide, a Class III Antiarrhythmic Drug, for Rapid Termination of Chronic Atrial Flutter or Fibrillation: Results of a Multicenter Placebo-Controlled Study
Authors: Bruce S. Stambler, Arthur S. Portnow, Mark A. Wood, James T. VanderLugt, Linda K. Wakefield, Kim T. Perry, Gail L. Jungbluth, Kenneth A. Ellenbogen
Journal: Journal of the American College of Cardiology (1995)
Rituximab for treatment of refractory/relapsing thrombotic thrombocytopenic purpura (TTP)
Authors: Afaq Ahmad, Anita Aggarwal, Daya Sharma, Harish P. Dave, Virginia Kinsella, Margaret E. Rick, Geraldine P. Schechter
Journal: American Journal of Hematology (2004)

Abstract Plasma exchange is the standard treatment for thrombotic thrombocytopenic purpura (TTP). For patients refractory to plasma exchange, treatment options are limited and often unsuccessful. The platelet thrombi that form in acquired TTP are believed to result from the presence of procoagulant ultralarge multimers of von Willebrand factor (VWF) in the circulation due to autoantibody inhibition of VWF cleaving protease (ADAMTS‐13), the enzyme that normally cleaves the ultralarge multimers. Rituximab, a chimeric monoclonal antibody against CD20, has been recognized as a useful therapy for antibody‐mediated autoimmune disease. We therefore treated four patients with recurrent TTP with 2 or 4 weekly doses of rituximab in addition to corticosteroids, vincristine, plasma, or continuing plasma exchange. Three patients responded with prompt improvement in microangiopathic hemolytic anemia and thrombocytopenia, which allowed plasma exchange to be discontinued or avoided and prednisone to be rapidly discontinued. Two of the 3 responders have remained in unmaintained complete remission for 13+ months. The third patient relapsed at 13 months; a second course of rituximab and prednisone resulted in an unmaintained remission for 6+ months. All four patients were tested for ADAMTS‐13 activity and its inhibitor at a point in their course when samples were available. Low ADAMTS‐13 activity was noted in 3 patients tested at relapse, and the inhibitor activity was detectable in 2 patients. ADAMTS‐13 activity increased during remission in one of these 2 patients although the patient had a persistence of the inhibitor. One patient tested only during remission had a normal ADAMTS‐13 level. We conclude that rituximab may have a role and deserves further study in the treatment of patients with relapsing TTP. Am. J. Hematol. 77:171–176, 2004. © 2004 Wiley‐Liss, Inc.
Cessation of Smoking-Reply
Authors: Alan Blum
Journal: JAMA (1981)

<h3>In Reply.—</h3> I sympathize with the difficulty of a physician in private practice to conduct a controlled, doubleblind study. It surely does not follow, however, that a private physician be accorded credence merely for claiming success with a new treatment tried on however many patients. And although it is not imperative that a pharmacologic rationale be found for a therapeutic method, persistence in using acupuncture sites—in the face of acupuncture's ineffectiveness in the treatment of cigarette smoking<sup>1</sup>— is unlikely to enhance the confidence of either the public or the medical profession in nicotine neutralization.
Atypical Multiple Myelomatosis
Authors: R. L. B. Beare, E. T. Knudsen
Journal: BMJ (1956)

McGeown and Montgomery (1956) reported a fatal case of multiple myelomatosis with many features of hyper- parathyroidism.A study of the serum proteins, how- ever, would have revealed the true condition in life.In October, 1955, a similar problem presented itself at this hospital.The results of the investigation of the serum proteins tended to exclude multiple myelomatosis,
Pulmonary Allergie Aspergillosis
Authors: Thomas M. Golbert, Roy Patterson
Journal: Annals of Internal Medicine (1970)

In pulmonary allergic aspergillosis the fungus grows in secretions of the respiratory tract. Its pathogenesis results from two types of hypersensitivity to aspergillus immediate, due to reaginic antibody, and toxic-complex, due to precipitating antibody. Both types were present in the serum of the first such case of a patient with pulmonary allergic aspergillosis reported in North America. The immediate and toxic-complex types of reactivity were transferred to the skin of rhesus monkey recipients. Passive systemic transfer to a rhesus recipient was accomplished by infusion of the patient's serum followed by aerosol challenge with aspergillus antigen. The recipient animal developed cutaneous reactivity and pulmonary lesions consistent with the donor's illness. Clinical manifestations of the patient were intermittent fever and cough with peripheral blood and sputum eosinophilia and fluctuating pulmonary infiltrates. The respiratory secretions contained Aspergillus fumigatus, but no evidence of lung tissue invasion was demonstrated by X ray or biopsy. The disease cleared rapidly with prednisone therapy and has remained absent for 2½ years after treatment.
Lung involvement in Sjogren's syndrome: a comparison between patients with primary and with secondary syndrome.
Authors: C Vitali, A Tavoni, G Viegi, E Begliomini, A Agnesi, S Bombardieri
Journal: Annals of the Rheumatic Diseases (1985)

Lung function was assessed in 20 patients with primary Sjögren's syndrome (SS) and in a group of patients with SS associated with a variety of connective tissue diseases. Signs of small airway disease and of altered diffusion capacity, together with chest x-ray features of mild interstitial involvement, were the most common findings in primary SS. On the whole, lung involvement was more frequent and severe in patients with the secondary form of the syndrome. In both primary and secondary SS lung function changes did not correlate with the other clinical and serological parameters, except for a more severe impairment of diffusion capacity in patients with Raynaud's phenomenon.
Psychiatric Treatment Of the Patient during Cancer Therapy
Authors: P. M. Silberfarb
Journal: CA A Cancer Journal for Clinicians (1988)

In summary, the physician should view abnormal behavior in the cancer patient as an early and important diagnostic sign that an underlying medical problem (such as hypercalcemia) may be present. Depression and insomnia yield to intervention with antidepressants and hypnotics in cancer patients as readily as in noncancer patients. Finally, attentive listening is in and of itself anxiety-relieving and can go a long way toward reducing the emotional distress of people with cancer.