Can Gastroduodenal Ulcers in NSAID Users Be Prevented?
Authors: Mark Feldman
Journal: Annals of Internal Medicine (1993)

Editorials15 August 1993Can Gastroduodenal Ulcers in NSAID Users Be Prevented?Mark FeldmanMark FeldmanUniversity of Texas Southwestern Medical Center, Department of Veterans Affairs Medical Center, Dallas, TX 75216.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-119-4-199308150-00015 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail Numerous epidemiologic and endoscopic studies have shown that regular use of prostaglandin synthesis inhibitors such as aspirin or other NSAIDs can lead to gastroduodenal [1] and intestinal ulcers [2]. It is not unusual for a regular NSAID user to have a life-threatening ulcer complication (bleeding or perforation). Among persons who ingest NSAIDs regularly, how often do clinically important ulcers occur? The answer to this important question is not yet known. It has been stated that symptomatic ulcers (that is, ulcers associated with pain or a complication such as bleeding or perforation) occur in approximately 1% of patients after use of ...References1. Cryer B, Feldman M. Effects of nonsteroidal anti-inflammatory drugs on endogenous gastrointestinal prostaglandins and therapeutic strategies for prevention and treatment of nonsteroidal anti-inflammatory drug-induced damage. Arch Intern Med. 1992; 152:1145-55. Google Scholar2. Allison MC, Howatson AG, Torrance CJ, Lee FD, Russell RI. Gastrointestinal damage associated with the use of nonsteroidal anti-inflammatory drugs. N Engl J Med. 1992; 327:749-54. Google Scholar3. Risk of GI ulceration, bleeding and perforation with nonsteroidal anti-inflammatory therapy. In: Physicians Desk Reference. 47th ed. Montvale, New Jersey: Medical Economics Data; 1993:2352. Google Scholar4. Cryer B, Goldschmiedt M, Redfern JS, Feldman M. 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Arch Intern Med. 1989; 149:775-9. Google Scholar19. Raskin JB, White R, Sue SO. Efficacy and safety of misoprostol in the prevention of NSAID-induced gastric ulcerspreliminary findings. Gastroenterology. 1993; 104:A177. Google Scholar Author, Article, and Disclosure InformationAffiliations: University of Texas Southwestern Medical Center, Department of Veterans Affairs Medical Center, Dallas, TX 75216.Corresponding Author: Mark Feldman, MD, Department of Veterans Affairs Medical Center, (111), 4500 South Lancaster Road, Dallas, TX 75216.Grant Support: By the Department of Veterans Affairs and the Southland Financial Corporation Distinguished Chair in Geriatrics. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoDuodenal and Gastric Ulcer Prevention with Misoprostol in Arthritis Patients Taking NSAIDs David Y. Graham , Richard H. White , Larry W. Moreland , Timothy T. Schubert , Robert Katz , Richard Jaszewski , Elizabeth Tindall , George Triadafilopoulos , Scott C. Stromatt , Leah S. Teoh , and Metrics Cited ByQuantitative estimation of rare adverse events which follow a biological progression: a new model applied to chronic NSAID useUlkusrisiko und-prophylaxe bei der Therapie mit nichtsteroidalen AntirheumatikaNonnarcotic Analgesics: Prevalence and Estimated Economic Impact of ToxicitiesGI Effects of OTC Analgesics: Implications for Product SelectionEffects of Nonsteroidal Antiinflammatory Drugs on Platelet Function and Systemic HemostasisGibt es eine effektive medikamentöse Prophylaxe der Ulcuskomplikationen? 15 August 1993Volume 119, Issue 4Page: 337-339KeywordsAbdominal painAspirinDuodenal ulcersGastric ulcersIbuprofenNSAIDsPeptic ulcersProstaglandinRheumatoid arthritisUlcers Issue Published: 15 August 1993 CopyrightCopyright © 1993 by American College of Physicians. All Rights Reserved.PDF DownloadLoading ...