tbuckley/cabot-search huggingface dataset:
Suppression of Autoimmunity and Renal Disease in Pristane‐Induced Lupus by Myeloperoxidase
Authors: Dragana Odobasic, Ruth C. M. Muljadi, Kim M. O'Sullivan, Anthony J. Kettle, Nina Dickerhof, Shaun A. Summers, A. Richard Kitching, Stephen R. Holdsworth
Journal: Arthritis & Rheumatology (2015)

Myeloperoxidase (MPO) locally contributes to organ damage in various chronic inflammatory conditions by generating reactive intermediates. The contribution of MPO in the development of experimental lupus is unknown. The aim of this study was to define the role of MPO in murine lupus nephritis (LN).LN was induced in C57BL/6 wild-type (WT) and MPO knockout (MPO(-/-) ) mice by intraperitoneal injection of pristane. Autoimmunity and glomerulonephritis were assessed 20 and 40 weeks after pristane administration. Cell apoptosis, leukocyte accumulation, and cytokine levels in the peritoneal cavity of WT and MPO(-/-) mice were assessed 3 or 6 days after pristane injection.MPO(-/-) mice developed more severe nephritis than did WT mice 20 and 40 weeks after pristane injection, despite having reduced glomerular deposition of antibody and complement and diminished levels of markers of oxidative stress (oxidized DNA and glutathione sulfonamide). Enhancement of renal disease in MPO-deficient mice correlated with increased accumulation of CD4+ T cells and macrophages in glomeruli, which, in turn, was associated with augmented generation of CD4+ T cell responses and increased activation and migration of dendritic cells in secondary lymphoid organs. In addition, the enhanced renal injury in MPO(-/-) mice was associated with increased glomerular accumulation of neutrophils and deposition of neutrophil extracellular traps. MPO deficiency also increased early cell apoptosis, leukocyte accumulation, and proinflammatory cytokine expression in the peritoneum.MPO attenuates pristane-induced LN by inhibiting early inflammatory responses in the peritoneum and limiting the generation of CD4+ T cell autoimmunity in secondary lymphoid organs.
A functional single‐nucleotide polymorphism in the <i> <scp>ERCC</scp> 1 </i> gene alters the efficacy of narrowband ultraviolet B therapy in patients with active vitiligo in a Chinese population
Authors: W. Dai, F.‐B. Zhou, C. Wei, X.‐W. Wang, S. Guo, X.‐L. Yi, K. Li, T.‐W. Gao, L. Liu, C.‐Y. Li
Journal: British Journal of Dermatology (2015)

T lymphocytes have been shown to cause the destruction of melanocytes in vitiligo pathogenesis. Narrowband ultraviolet B (NB-UVB), as an effective therapeutic strategy in vitiligo, can lead to the formation of DNA photoproducts such as cyclobutane pyrimidine dimers (CPDs) in perilesional lymphocytes and thus induce skin immunosuppression. The repair of DNA photoproducts is performed mainly through the nucleotide excision repair (NER) pathway. We hypothesized that single-nucleotide polymorphisms (SNPs) in NER genes might influence the repair capacity of CPDs and thus contribute to variations in phototherapy efficiency.To detect genetic polymorphisms in NER genes and their relationship with the efficacy of NB-UVB therapy in patients with active vitiligo.We investigated the association of NER SNPs (XPA A23G, XPC Ci11A, XPC C2919A and ERCC1 C118T) with phototherapy efficacy in 86 patients with vitiligo who received NB-UVB treatment. Furthermore, we examined the impact of ERCC1 C118T on the apoptosis of T lymphocytes and CPD accumulation after NB-UVB irradiation.We found that patients with vitiligo with the ERCC1 codon 118 CC genotype showed better efficacy after NB-UVB irradiation than those with the ERCC1 118 TT and CT genotypes, whereas no such association was documented among the genotypes of XPA A23G, XPC Ci11A or XPC C2919A. Additionally, the apoptosis rates and CPD levels of lymphocytes after NB-UVB irradiation in patients with the ERCC1 118 CC genotype were significantly higher than those in patients with the ERCC1 118 TT and CT genotypes.The ERCC1 118 CC genotype confers better efficacy of NB-UVB therapy in patients with active vitiligo.
Prevalence of Chlamydial and Gonococcal Infections Among Young Adults
Authors: Charlotte A Gaydos, Kelly T McKee, Thomas C Quinn, Joel C Gaydos
Journal: JAMA (2004)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
UNILATERAL RENAL TUBERCULOSIS ASSOCIATED WITH HYPERTENSION
Authors: G. Gill Richards
Journal: Annals of Internal Medicine (1941)

Case Reports1 August 1941UNILATERAL RENAL TUBERCULOSIS ASSOCIATED WITH HYPERTENSIONG. GILL RICHARDS, M.D., F.A.C.P.G. GILL RICHARDS, M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-15-2-324 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptBecause Goldblatt1 could, by removing the ischemic kidney in his experimental hypertensive dogs, cause a fall of blood pressure to normal, the possible clinical application of his results to cases of essential hypertension in man aroused considerable interest, particularly among internists and urologists. The following report deals with a case of unilateral renal tuberculosis with hypertension and the satisfactory result which has continued for 11 months after nephrectomy.CASE REPORTL. P., a married white male, aged 37 years, was admitted to the Latter-Day Saints Hospital on January 10, 1940, complaining of occipital headaches of extreme degree, fatigue, shortness of...Bibliography1. GOLDBLATT H: Studies on experimental hypertension due to renal ischemia, ANN. INT. MED., 1937, xi, 69-103. LinkGoogle Scholar2. BUTLER AM: Chronic pyelonephritis and arterial hypertension, Jr. Clin. Invest., 1937, xvi, 889-897. CrossrefGoogle Scholar3. BARNEYSUBY JDHI: Unilateral renal disease with arterial hypertension, New England Jr. Med., 1939, ccxx, 744-746. CrossrefGoogle Scholar4. CRABTREE EG: Hypertension in destructive infected unilateral lesions of the kidney, Trans. Am. Assoc. Genito-Urin. Surgeons, 1938, xxxi, 299-319. Google Scholar5. LEADBETTERBURLAND WFCE: Hypertension in unilateral renal disease, Jr. Urol., 1938, xxxix, 611-626. CrossrefGoogle Scholar6. BOYDLEWIS CHLG: Nephrectomy for arterial hypertension, Jr. Urol., 1938, xxxix, 627-635. CrossrefGoogle Scholar7. BARKERWALTERS NWW: Hypertension and chronic pyelonephritis: results of nephrectomy, Jr. Am. Med. Assoc., 1940, cxv, 912-916. CrossrefGoogle Scholar8. FITZ R: Hypertension, Mississippi Doctor, 1940, xvii, 531-541. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Salt Lake City, Utah*Received for publication December 27, 1940. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byAtypical causes of curable renovascular hypertension: A reviewRenal hypertension secondary to renal tuberculosisAmelioration of Asthma and Hypertension after Nephrectomy for Renal TuberculosisUnilateral Nephrectomy in Hypertensive DiseaseHypertension in Unilateral Renal Disease 1 August 1941Volume 15, Issue 2Page: 324-328KeywordsBlood pressureFallsFatigueHypertensionKidneysNephrectomy ePublished: 1 December 2008 Issue Published: 1 August 1941 PDF downloadLoading ...
Abstract 03: Outpatient Care Preceding Incident Heart Failure (HF) and Implications for Long-Term Outcomes. The Atherosclerosis Risk in Communities (ARIC) Study
Authors: Anna Kucharska-Newton, Lloyd Chambless, Ricky Camplain, Carmen Cuthbertson, Patricia Chang, Sunil Agarwal, Lisa Wruck, Norrina Allen, Eyal Shahar, Alain Bertoni, Gerardo Heiss
Journal: Circulation (2015)

Hypothesis: We hypothesized that outpatient management of patients at risk for a HF hospitalization is associated with lower mortality following an incident HF hospitalization. Methods: Patterns of outpatient visits prior to incident HF hospitalization were assessed among CMS Medicare beneficiaries with continuous fee-for-service eligibility residing during 2003-2006 in four geographic areas of CVD surveillance conducted by the ARIC Study. Incident HF hospitalization was defined as hospitalization with ICD9 code 428.x with no HF hospitalizations in preceding 2 years. Outpatient visits to primary care physicians, general internists, or cardiologists were identified from Carrier files. A comorbidity score was calculated from ICD9 codes at the time of incident HF hospitalization. Cox proportional hazard models adjusted for age, comorbidity score, gender, and race were used to estimate mortality. Results: Mean age among beneficiaries with observed incident HF hospitalization (n=2006; 90.4% white, 45.1% male) was 79.8 years (SD 7.4). Mean comorbidity score was 3.6 (SD 1.9). Mean number of outpatient physician visits occurring in two years preceding the incident HF hospitalization, was 9.6 (SD 9.0); 19.6% beneficiaries had no observed prior outpatient physician visits. Risk of death within one year of incident HF hospitalization was greater among those with no preceding outpatient physician visits as compared to those with at least one physician visit (adjusted HR=1.81 (95% CI 1.50, 2.18); Figure). Adjustment for the presence of an outpatient visit within 2 weeks following the HF hospitalization attenuated the risk of death (HR=1.56 (1.29, 1.89)). Conclusion: Lack of outpatient care in two years prior to a HF-related hospitalization is associated with increased mortality within one year following hospitalization. Further inquiry is warranted to assess whether the association reflects diversity in causes/manifestations of HF, ambulatory care received in ED settings, or benefits associated with outpatient care.
MicroRNAs in control of cell proliferation
Authors: Anindya Dutta
Journal: Clinical Cancer Research (2008)

ED02-03   We are using three approaches to discover microRNAs that regulate cell proliferation. In the first approach, we focused on miRNAs induced during differentiation of C2C12 myoblasts into myotubes  in vitro . One of the microRNAs induced during differentiation, miR-206, suppresses cell proliferation. By surveying mRNAs that are downregulated by miR-206 for genes predicted to be targets of the microRNA, we discovered the mRNA of DNA polymerase alpha p180 is a direct target that is destabilized upon miR-206 transfection. We now report that additional microRNAs induced during muscle differentiation target other cell-cycle regulators.  After noting that targeted mRNAs are often destabilized by microRNAs, in the second approach, we tested whether global downregulation of microRNAs by knockdown of Dicer or Drosha can help identify microRNA-repressed mRNAs. The principle was proved by the discovery that HMGA2 oncogene is repressed by the growth-suppressive let-7 microRNA. Indeed, chromosomal translocations in lipomas and leiomyomas de-repress HMGA2 by deleting the 39 UTR that is normally repressed by let-7. Conversely, downregulation of let-7 has been noted in lung cancers and large leiomyomas and is correlated with over-expression of the HMGA2 oncogene.  In the third approach we have cloned short RNAs from androgen-dependent prostate cancer cells grown in the presence or absence of androgens and subjected them to ultra-high-throughput sequencing. The frequency of a number of clones present in the libraries is changed by androgens and we have identified several microRNAs that change upon androgen-depletion. Over 30-40% of the short RNAs cloned, however, do not correspond to known microRNAs and are produced by cleavage of known mRNAs and noncoding RNAs. The diversity and abundance of the non-micro-short RNAs (nmsRNAs) contrast with how little is known of their function and suggest that much remains to be done before we understand the biological functions of many short RNAs present in the cell. In an extension of the project we have identified several microRNAs that are reproducibly altered in expression level between the androgen-dependent LnCAP cells and androgen-independent derivative C4-2 cells. Interestingly, the microRNAs decreased in C4-2 cells were also reported by others to be decreased as prostate cancers advance in Gleason score or metastasize. This raises the possibility that a microRNA signature may be established for following the molecular stage of prostate cancer and for predicting its predilection to recur in an androgen-independent form.
Spinal Cord Compression in Paget's Disease of Bone Treated Medically
Authors: A S M Jawad, H Berry
Journal: Journal of the Royal Society of Medicine (1987)

The most common sites for Paget's disease of the spine are the sacrum followed by the lumbar spine 1 , but paraparesis is more common with dorsal involvement. Over 100 cases of dysfunction of the spinal cord or cauda equina secondary to Paget's disease of the vertebral column have been described since it was first reported by Wyllie 2 . We report a patient with paraparesis secondary to Paget's disease of the dorsal vertebrae with complete myelographic obstruction, who was treated medically with disodium etidronate.
THE USE OF METHYL-ISO-OCTENYLAMINE IN MIGRAINE
Authors: P S MacNEAL, D DAVIS
Journal: Annals of Internal Medicine (1947)

Article1 April 1947THE USE OF METHYL-ISO-OCTENYLAMINE IN MIGRAINEPERRY S. MACNEAL, M.D., F.A.C.P., DAVID DAVIS, M.D.PERRY S. MACNEAL, M.D., F.A.C.P.Search for more papers by this author, DAVID DAVIS, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-26-4-526 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe mechanism by which headache is produced in the migrainous patient is not entirely understood but it almost certainly is a vascular phenomenon dependent upon alterations in caliber of the cerebral, dural, or scalp vessels. Those drugs which most commonly relieve the pain are sympathicomimetic and vasoconstrictor in their action. Of these the one which has best stood the test of time is ergotamine tartrate (Gynergen, Sandoz), but there are certain disadvantages to the use of this material. Aside from dangers of ergotism from prolonged administration, there are frequently unpleasant symptoms such as nausea, vomiting, paresthesias in the hands, and...Bibliography1. HORTONPETERSBLUMENTHAL BTGALS: A new product in the treatment of migraine: A preliminary report, Proc. Staff Meet. Mayo Clin., 1945, xx, 241-248. Google Scholar2. PALMER H: Migraine headache, Clinics, 1945, iv, 531-554. Google Scholar3. WALTONPREACHER RPCB: Toxicity of methylamino-iso-octene, Federation Proc., 1946, v, 211. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: *Received for publication June 25, 1946.†"Octin," manufactured by the Bilhuber-Knoll Corporation, of Orange, N. J., who kindly supplied the material for this investigation. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byPharmacological analysis of the mechanisms involved in the tachycardic and vasopressor responses to the antimigraine agent, isometheptene, in pithed ratsInhibition of pancreatic exocrine secretion and bile entry into the duodenum by isometheptene, a sympathomimetic agentMigraine: A 1950 SymposiumSOME THERAPEUTIC RESULTS IN CASES OF MIGRAINEHeadache as an Emergency Complaint 1 April 1947Volume 26, Issue 4Page: 526-527KeywordsDrugsHeadachesMigraineNauseaVomiting ePublished: 1 December 2008 Issue Published: 1 April 1947 PDF downloadLoading ...
TSC1 controls IL-1β expression in macrophages via mTORC1-dependent C/EBPβ pathway
Authors: Tao Yang, Linnan Zhu, Yanhua Zhai, Qingjie Zhao, Jianxia Peng, Hongbing Zhang, Zhongzhou Yang, Lianfeng Zhang, Wenjun Ding, Yong Zhao
Journal: Cellular and Molecular Immunology (2015)
Presidential Candidates’ Commentaries
Authors: Stephen J Jay
Journal: JAMA (2005)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Fluid, Electrolyte, and Acid-Base Disorders.
Authors: Allen I. Arieff, Ralph A. DeFronzo
Journal: Annals of Internal Medicine (1988)

SECTION I NORMAL WATER and ACID-BASE REGULATION: Regulation of Intra- And Extracellular Volume. Sodium Metabolism and Maintenance of Extracellular Fluid Volume. Edema-Forming States. Acid-Base Regulation: Cellular and Whole-Body. Classification of Acid-Base Disturbances. Metabolic Acidosis. Acid-Base Disturbances in Pulmonary Medicine. Disorders of Sodium Metabolism. Hyponatremia, Hypernatremia. Disorders of Postassium Metabolism. Hyperkalemia, Hypokalemia. Calcium Homeostasis and Disorders of Calcium Metabolism. Disorders of Magnesium Metabolism. Physiology of Phosphorus Metabolism and Pathophysiology of Hypo-And Hyperphosphatemia SECTION 2 SPECIFIC PATHOLOGIC STATES and SPECIAL CONSIDERATIONS: Clinical Manifestations of Electrolyte and Acid-Base Disorders. Total Parenteral Nutrition and Its Complications. Fluid and Electrolyte Therapy in Critically Ill Patients and Those Who Are Pre-, Post-, Or Intraoperative. Acute Renal Failure. Chronic Renal Failure. Metabolic Encephalopathy as a Complication of Acid-Base and Electrolyte Disorders. Fluid, Electrolyte, And Acid-Base Complications of Diabetic Emergencies. The Liver and Acid-Base Regulation in Health and Disease. Fluid, Electrolyte, And Acid-Base Complications of Dialysis. Metabolic Disorders Associated with Gastrointestinal Disease. Fluid and Electrolyte Metabolism in Normal and Abnormal Pregnancy. Fluid and Electrolyte Therapy in Infants and Children . Ageing and Renal Function
Abstract 16796: Sub-millisievert Radiation Dose with Retained Image Quality in Patients Undergoing Coronary Computed Tomographic Angiography using 80 kV Tube Voltage: A Prospective Multicenter Multivendor Randomized Trial
Authors: Troy M LaBounty, Jonathon Leipsic, Brett Heilbron, G.B. John Mancini, Millie Gomez, David Wood, Monvadi B Srichai, Fay Y Lin, Carolyn Taylor, Nikki Ariaratnam, Jonathan W Weinsaft, James K Min
Journal: Circulation (2010)

Introduction: Coronary computed tomographic angiography (CCTA) is associated with non-negligible radiation doses; current Methods: to lower radiation dose include the use of decreased 100 kV tube v...
Continuous Positive Airway Pressure and Postoperative Hypoxemia—Reply
Authors: V. Marco Ranieri, Vincenzo Squadrone
Journal: JAMA (2005)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Erectile Dysfunction in Obese Men
Authors: David H Sarne
Journal: JAMA (2004)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal