tbuckley/cabot-search huggingface dataset:
On the clinical value of calibrated displacement apexcardiography.
Authors: B Denef, R Popeye, H D Geest, H Kesteloot
Journal: Circulation (1975)

A new type of displacement transducer for recording the calibrated left apexcardiogram (QLAC) has been evaluated in 69 normal subjects and 99 cardiac patients. Total displacement of QLAC (TD), its peak first derviative (peak dD/dt (t-peak dD/dt). A strong corretation exists between peak dD/dt and TD in normal subjects (r=0.95) and the deviation from the normal relationship allows a separation between normal and abnormal ventricular function. In normal subjects (dD/dt/Dt) max averaged 34.2 plus or minus 5.7 sec-1; it was signigicantly lower in patients with congestive cardiomyopathy (26.5 plus or minus 6.3 sec-1 p greater than 0.005). This index correlates with left ventricular end-diastolic pressure (LVEDP) (R = - 0.69) and with ejection fraction (R - 0.66) and behaves as expected during positive and NEGATIVE INOTROPIC interventions. The index (dD/dt/Dt) max is superior to TD and peak dD/dt, being less variable independent of thorax circumference and better correlated with hemodynamic parameters. The index t-peak dD/dt was 53.9 plus or minus 9.5 msec in normal subjects and 81.6 plus or minus 18.9 msec in patients with congestive cardiomyopathy (p greater than 0.001). This time-interval correlates weakly with LVEDP (R = 0.04) and with ejection fraction (R = - 0.66). It is concluded that the normalized first derivative of QLAC provides useful information on left ventricular function.
Phase 2 and pharmacodynamic study of oral forodesine in patients with advanced, fludarabine-treated chronic lymphocytic leukemia
Authors: Kumudha Balakrishnan, Dushyant Verma, Susan O'Brien, John Michael Kilpatrick, Yuling Chen, Brenita F. Tyler, Susan Bickel, Shanta Bantia, Michael J. Keating, Hagop Kantarjian, Varsha Gandhi, Farhad Ravandi
Journal: Blood (2010)
A novel chronic lymphocytic leukemia subset expressing mutated IGHV3-7-encoded rheumatoid factor B-cell receptors that are functionally proficient
Authors: R Hoogeboom, T A Wormhoudt, M R Schipperus, A W Langerak, D K Dunn-Walters, J E J Guikema, R J Bende, C J M van Noesel
Journal: Leukemia (2012)
CONCEALED TRAUMATIC MENINGEAL HEMORRHAGE.
Authors: H. REINEKING
Journal: JAMA (1899)

The appropriateness of the title of my paper may, strictly speaking, well be questioned, for to the well-informed physician or surgeon no intracranial hemorrhage, of any considerable amount, could long remain<i>concealed</i>. I have applied the term, and shall limit my remarks, to cases in which there is absence of outward flow of blood and of fracture or fissure of the cranium, but in which the presence of a hemorrhage is usually indicated by unmistakable symptoms relating to the intellectual, sensory and motor functions. The following case illustrates so typically the usual symptomatology and course, as well as the results to be expected both under the expectant and the operative plans of treatment of this important class of cases, that I wish to put it on record, and might well offer it in lieu of any dissertation on the subject. If, in attempting to present briefly the most advanced views
2005 VIROLOGIC RESPONSE RATES FOLLOWING 4 WEEKS OF FILIBUVIR IN COMBINATION WITH PEGYLATED INTERFERON ALFA-2A AND RIBAVIRIN IN CHRONICALLY-INFECTED HCV GENOTYPE-1 PATIENTS
Authors: I. Jacobson, P.J. Pockros, J. Lalezari, E. Lawitz, M. Rodriguez-Torres, E. DeJesus, F. Haas, C. Martorell, R. Pruitt, V. Purohit, S. Srinivasan, S. Jagannatha, K. Rana, J. Hammond
Journal: Journal of Hepatology (2010)
MyD88-dependent induction of allergic Th2 responses to intranasal antigen
Authors: Damani A. Piggott, Stephanie C. Eisenbarth, Lan Xu, Stephanie L. Constant, James W. Huleatt, Christina A. Herrick, Kim Bottomly
Journal: Journal of Clinical Investigation (2005)

MyD88 is a common Toll-like receptor (TLR) adaptor molecule found to be essential for induction of adaptive Th1 immunity. Conversely, innate control of adaptive Th2 immunity has been shown to occur in a MyD88-independent manner. In this study, we show that MyD88 is an essential innate component in the induction of TLR4-dependent Th2 responses to intranasal antigen; thus we demonstrate what we believe to be a novel role for MyD88 in pulmonary Th2 immunity. Induction of the MyD88-independent type I IFN response to LPS is defective in the pulmonary environment. Moreover, in the absence of MyD88, LPS-induced upregulation of costimulatory molecule expression on pulmonary DCs is defective, in contrast to what has been observed with bone marrow–derived DCs (BMDCs). Reconstitution of Th2 responses occurs upon adoptive pulmonary transfer of activated BMDCs to MyD88-deficient recipients. Furthermore, the dependence of Th2 responses on MyD88 is governed by the initial route of antigen exposure; this demonstrates what we believe are novel site-specific innate mechanisms for control of adaptive Th2 immunity.
Unfavorable Effect of Atropine-Diphenoxylate (Lomotil) Therapy in Lincomycin-Caused Diarrhea
Authors: Ervin Novak
Journal: JAMA (1976)

In this double-blind, randomized study, 200 normal subjects received a three-day course of one of five treatment regimens: lincomycin hydrochloride monohydrate injection (sterile solution, 300 mg/ml) with two tablets of either placebo, a mixture of atropine sulfate and diphenoxylate hydrochloride (Lomotil), an aspirin-phenacetin-caffeine (APC) combination or the latter with codeine, or an injection of saline with two placebo tablets. Gastrointestinal irritation was most prominent in subjects receiving lincomycin with atropine-diphenoxylate and lincomycin with APC plus codeine (P less than .05). Decreased intestinal motility from atropine-diphenoxylate or codeine may increase the contact time between the lincomycin (or its metabolites) or some developing toxic substances and the mucosal epithelium. The use of atropine-diphenoxylate or codeine in treating lincomycin-induced diarrhea may be questionable.
I don't want you to see a psychiatrist.
Authors: L. Mynors-Wallis
Journal: BMJ (1988)

<h3>Introduction</h3> Patients with cancer undergoing surgery often suffer from reduced quality of life and various forms of distress. Untreated distress can negatively affect coping resources as well as surgical and oncological outcomes. A virtual reality-based stress reduction intervention may increase quality of life and well-being and reduce distress in the perioperative phase for patients with cancer. This pilot trial aims to explore the feasibility of the proposed intervention, assess patient acceptability and obtain estimates of effect to provide data for sample size calculations. <h3>Methods and analysis</h3> Patients with colorectal cancer and liver metastasis undergoing elective surgery will be recruited for this single-centre, randomised pilot trial with a three-arm design. A total of 54 participants will be randomised at 1:1:1 ratio to one of two intervention groups or a control receiving standard treatment. Those randomised to an intervention group will either receive perioperative virtual reality-based stress reduction exercises twice daily or listen to classical music twice daily. Primary feasibility outcomes are number and proportions of participants recruited, screened, consented and randomised. Furthermore, adherence to the intervention, compliance with the completion of the quality of life questionnaires and feasibility of implementing the trial procedures will be assessed. Secondary clinical outcomes are measurements of the effectiveness of the interventions to inform sample size calculations. <h3>Ethics and dissemination</h3> The study protocol, the patient information and the informed consent form have been approved by the ethics committee of the Ludwigs-Maximilians-University, Munich, Germany (Reference Number: 19–915). Study findings will be submitted for publication in peer-reviewed journals. <h3>Trial registration number</h3> DRKS00020909.
The Supreme Court and the Affordable Care Act
Authors: Robert B. Doherty
Journal: Annals of Internal Medicine (2013)

Letters5 March 2013The Supreme Court and the Affordable Care ActRobert B. Doherty, BARobert B. Doherty, BAFrom American College of Physicians, Washington, DC.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-158-5-201303050-00018 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail IN RESPONSE:I respectfully disagree with Dr. Vaccarezza's characterization that the uninsured consists of people who could afford coverage but choose to spend money on “nonessential pleasures.” The Kaiser Family Foundation and the Urban Institute report that “the vast majority of uninsured people are in low- or moderate-income families. Individuals below poverty are at the highest risk of being uninsured, and this group comprises 38% of the uninsured population (the poverty level for a family of four was $22,350 in 2011). In total, nine out of ten uninsured people are in low- or moderate-income families, meaning they are below 400% ...References1. The Kaiser Commission on Medicaid and the Uninsured. The Uninsured—A Primer: Key Facts About Americans Without Health Insurance. Menlo Park, CA: The Henry J. Kaiser Family Foundation; 2012. Accessed at www.kff.org/uninsured/upload/7451-08.pdf on 29 November 2012 Google Scholar2. Banthin J, Harvey H, Hearne J. Estimates for the Insurance Coverage Provisions of the Affordable Care Act Updated for the Recent Supreme Court Decision. Washington, DC: Congressional Budget Office; 2012. Accessed at www.cbo.gov/sites/default/files/cbofiles/attachments/43472-07-24-2012-CoverageEstimates.pdf on 29 November 2012 Google Scholar3. Dorn S. Uninsured and Dying Because of It: Updating the Institute of Medicine Analysis on the Impact of Uninsurance on Mortality. Washington, DC: Urban Institute; 2008. Accessed at www.urban.org/UploadedPDF/411588_uninsured_dying.pdf on 29 November 2012 Google Scholar Author, Article, and Disclosure InformationAffiliations: From American College of Physicians, Washington, DC.Disclosures: Disclosures can be viewed at www.acponline.org/authors/icmje/ConflictOfInterestForms.do?msNum=M12-1687. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoThe Supreme Court and the Affordable Care Act: Milestone or Detour on the Road to Universal Coverage? Robert B. Doherty The Supreme Court and the Affordable Care Act Stephen Vaccarezza Metrics 5 March 2013Volume 158, Issue 5_Part_1Page: 364KeywordsConflicts of interestDecision makingDisclosureHealth insurance ePublished: 5 March 2013 Issue Published: 5 March 2013 Copyright & PermissionsCopyright © 2013 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Chromosome aberrations detected by conventional karyotyping using novel mitogens in chronic lymphocytic leukemia with “normal” FISH: correlations with clinicobiologic parameters
Authors: Gian Matteo Rigolin, Francesca Cibien, Sara Martinelli, Luca Formigaro, Lara Rizzotto, Elisa Tammiso, Elena Saccenti, Antonella Bardi, Francesco Cavazzini, Maria Ciccone, Ilaria Nichele, Giovanni Pizzolo, Francesco Zaja, Renato Fanin, Piero Galieni, Alessia Dalsass, Francesca Mestichelli, Nicoletta Testa, Massimo Negrini, Antonio Cuneo
Journal: Blood (2012)
Recurrent Kaposi's varicelliform eruption in Darier's disease
Authors: P.G. HIGGINS, K.D. CROW
Journal: British Journal of Dermatology (2006)

This paper describes five attacks of Kaposi's varicelliform eruption which occurred during a period of 18 months in a woman with Darier's disease. Herpes simplex virus type i was isolated from the lesions in three of the four episodes which were studied in the laboratory and Coxsackievirus type A16 from the remaining attack. It is suggested that Coxsackievirus A16 may be a hitherto overlooked cause of Kaposi's varicelliform eruption.
Colony morphology of piliated Neisseria meningitidis.
Authors: M S Blake, C M MacDonald, K P Klugman
Journal: The Journal of Experimental Medicine (1989)

An association between piliation and colony morphology has not been observed for the meningococcus. We have found that growth of meningococci overnight at 30 degrees C in a candle extinction jar allows observation of distinct colonial phenotypes correlated to the presence or absence of piliation and the expression of opacity-associated proteins. These phenotypes are similar to those observed in gonococci grown overnight at 37 degrees C.
How Useful Are Serum Digitalis Measurements?
Authors: Louis Lasagna
Journal: New England Journal of Medicine (1976)

Throughout most of its history, the practice of medicine has been conducted without concern for the levels of drugs in body fluids and tissues. In part this state of affairs was occasioned by methodologic deficiencies, but even after the advent of sophisticated assay technics there was little interest in drug measurements, with the exception of certain chemotherapeutic agents and the management (or at least the forensic work-up) of poisoned patients.The flowering of clinical pharmacology and pharmacokinetics has changed all that. Measurements of biologic fluid concentrations for a number of drugs are now routinely available in many hospitals, and special . . .
Human Lung Carcinogen--DNA Adduct Levels Mediated by Genetic Polymorphisms In Vivo
Authors: S. Kato, E. D. Bowman, A. M. Harrington, B. Blomeke, P. G. Shields
Journal: JNCI Journal of the National Cancer Institute (1995)

Cancer risk from exposure to tobacco smoke varies widely from person to person, depending in part on the status of particular genes and acquired susceptibilities. Certain genes determine how cells activate and detoxify carcinogens. Activated carcinogen metabolites may bind to DNA and form DNA adducts (e.g., 7-methyl-2'-deoxyguanosine-3'-monophosphate [7-methyl-dGMP] and polycyclic aromatic hydrocarbons-dGMP [PAHs-dGMP]), many of which can induce genetic mutations. Thus, if individuals have an increased capacity to activate carcinogens, they might form more carcinogen-DNA adducts and subsequently have an increased risk of cancer.Using DNA-adduct detection methods specific for 7-methyl-dGMP and PAH-dGMP, we sought to determine whether an inherited genetic susceptibility to cancer associated with certain carcinogen-metabolizing and detoxifying genes (e.g., cytochrome P450 and glutathione S-transferase) is related to DNA adduct formation in lung tissue.Human lung tissues were collected randomly from 90 autopsy donors who were free of cancer. Levels of 7-methyl-dGMP, a metabolic product of N-nitrosamines, and PAH-dGMP adducts were determined in lung tissue specimens by use of micropreparative DNA purification steps combined with a 32P-postlabeling assay. Genetic polymorphisms (the presence of different genes and/or alleles) were determined for the cytochrome P450 genes, CYP2D6, CYP2E1, and CYP1A1, as well as for glutathione S-transferase M1 (GSTM1). Statistical differences among adduct levels for the study variables, including genotypes, were assessed by the two-sided Student's t test or the Mann-Whitney U test.Higher 7-methyl-dGMP adduct levels were associated with CYP2D6 genotypes (P = .01), consistent with the reports of the increased risk of lung cancer associated with this genotype. Higher adduct levels were also associated with CYP2E1 minor alleles (P = .05). In both cases, the association was attributed mostly to individuals with low serum cotinine levels (P = .004 and P = .05, respectively), suggesting that the effect of the genotypes is mostly in nonsmokers exposed to either passive tobacco smoke or to N-nitrosamine exposures other than tobacco smoke or to N-nitrosamine exposures other than tobacco smoke. Separately, the presence of PAH-dGMP adducts was associated with the GSTM1 null genotype (absence of the gene) (odds ratio = 8.6; 95% confidence interval = 1.03-100).This study finds that the levels of two different carcinogen-DNA adducts vary in lung tissue (an important target tissue) in association with three separate genetic polymorphisms (i.e., CYP2D6, CYP2E1, and GSTM1). CYP2D6 and CYP2E1 genotypes are associated with higher 7-methyl-dGMP levels, while the GSTM1 null genotype is associated with higher numbers of PAH-dGMP adducts. These findings suggest that genetic polymorphisms are predictive of carcinogen-DNA adduct levels and would thus be predictive of an individual's lifetime response to carcinogen exposure.
"Wear and Tear" Protein
Authors: Max Wishnofsky
Journal: JAMA (1961)

<h3>To the Editor:—</h3> In the article, "Nutrition in Chronic Renal Failure," inThe Journal, June 25, 1960, page 905, Dr. A. J. Merrill, in discussing protein metabolism in chronic nephritis, states as follows: "Estimates by authorities vary from almost no protein content in the butter-sugar-cornstarch diet of Borst, to 20 Gm. of protein per day in the rice diet suggested by Kempner, and 1 Gm. of protein per kilogram per day in the diet as suggested by Burnett.... The minimum for wear-and-tear replacement is 0.5 Gm. of protein per kilogram of body weight.... Raising carbohydrate intake above 100 Gm. in normal subjects failed to produce much more protein-sparing action in six to eight days than the 100 Gm. carbohydrate diet." An intake of 0.5 Gm. of protein per kilogram of body weight per day does not represent "wear-and-tear" protein. The term "wear-and-tear" quota of protein was coined by Rubner to
Endurance training–induced changes in the insulin response to oral glucose are associated with the peroxisome proliferator–activated receptor-γ2 Pro12Ala genotype in men but not in women
Authors: Edward P. Weiss, Onanong Kulaputana, Ioana A. Ghiu, Josef Brandauer, Christopher R. Wohn, Dana A. Phares, Alan R. Shuldiner, James M. Hagberg
Journal: Metabolism (2004)
FRACTURE OF PATELLA.
Authors: MILTON JAY
Journal: JAMA (1899)

Fractures of the patella are not of frequent occurrence; they constitute about 2 per cent, of all fractures, and are found more frequently in the male than in the female—in the proportion of about five to one. Fractures of this bone demand careful consideration, on account of its close proximity to the knee-joint, and also in consequence of the imperfect way in which the fragments unite; fracture of the patella is caused by muscular action or direct violence. The direction of the fracture may be transverse, vertical, oblique or even stellate. In the fracture produced by sudden and violent muscular contraction, the transverse variety usually occurs; when the fracture is caused by direct violence, the direction may be vertical, transverse, oblique or stellate, or the fracture may be comminuted. In fracture of the patella the kneejoint is always opened, unless the extreme lower end of the patella is broken, in
Primary T-cell immunodeficiency with immunodysregulation caused by autosomal recessive LCK deficiency
Authors: Fabian Hauck, Clotilde Randriamampita, Emmanuel Martin, Stéphane Gerart, Nathalie Lambert, Annick Lim, Jean Soulier, Zosia Maciorowski, Fabien Touzot, Despina Moshous, Pierre Quartier, Sébastien Heritier, Stéphane Blanche, Fréderic Rieux-Laucat, Nicole Brousse, Isabelle Callebaut, André Veillette, Claire Hivroz, Alain Fischer, Sylvain Latour, Capucine Picard
Journal: Journal of Allergy and Clinical Immunology (2012)
SUGGESTIONS FOR THE RECONSTRUCTION OF SYPHILITIC NOSES.
Authors: JOHN B. ROBERTS
Journal: JAMA (1901)

Nasal deformity from syphilitic destruction of bone and cartilage is a very frequent result of the tertiary stage of the disease. The disfigurement varies in extent and character, but is always very noticeable because of the importance of the nose in facial contour. The mental distress of the patient is usually acute, because the disfigurement is associated in the public mind with a loathesome and disgraceful disease. The fact that syphilis may be inherited or be acquired in an innocent manner avails little in the public's estimate of a person carrying ever upon his countenance the well-known mark of sexual impurity. Nearly every other lesion of syphilis may be concealed from public observation, or may at least be attributable to diseases of a less dishonorable nature. The patient with the sunken or distorted nose of syphilis has, however, scarcely any shield to protect him from impertinent scrutiny and the innuendo
Health-related quality of life in patients with melanoma expressed as utilities and disability weights
Authors: I. Tromme, B. Devleesschauwer, P. Beutels, P. Richez, A. Leroy, J.-F. Baurain, F. Cornelis, C. Bertrand, N. Legrand, J. Degueldre, L. Thomas, C. Legrand, J. Lambert, J. Haagsma, N. Speybroeck
Journal: British Journal of Dermatology (2014)

Few studies about health-related quality of life (HRQoL) in patients with melanoma have expressed their results in terms of utilities or disability weights (DWs). Utilities are required for calculating quality-adjusted life years and therefore for cost-effectiveness analyses. DWs are useful to assess the burden of diseases through disability-adjusted life years.To provide utilities and DWs regarding patients with melanoma.The patients were classified into eight groups using four stages based on the 2009 American Joint Committee on Cancer stages, with each stage subdivided into treatment and remission phases. The EuroQoL Five Dimensions Five Levels (EQ-5D-5L) questionnaire was completed by the patients with melanoma to provide a mean utility for each group. In addition to this, the EuroQoL visual analogue scale (VAS) and a validated quality-of-life questionnaire dedicated to patients with melanoma [Functional Assessment of Cancer Therapy Melanoma (FACT-M)] were completed by the same patients in order to compare their results with the obtained utilities. DWs were obtained by calculating, for each patient, the difference between his/her utility and the corresponding sex- and age-specific population norm.A total of 395 questionnaire sets were completed. Utilities and DWs showed significant differences between follow-up groups. Treatment groups had similar utilities and DWs but these results were obtained during different treatment durations and therefore have different weights. The VAS and the FACT-M were found to be less sensitive. Nevertheless, the FACT-M identified some problems not found by the EQ-5D-5L questionnaire.The EQ-5D-5L questionnaire seems adequate to provide utilities and DWs in patients with melanoma. Lower HRQoL in female patients with melanoma is probably linked to lower HRQoL in the general population.
Inhibition of Measles Rash by Chickenpox
Authors: Vernon Knight, William F. Fleet, David J. Lang
Journal: JAMA (1964)

A CASE was recently observed in which measles had onset one week following chickenpox. Surrounding each chickenpox lesion was a zone of normal-appearing skin which never became involved with measles rash. These findings suggested the natural occurrence of a local viral interference phenomenon. <h3>Report of a Case</h3> A 7-year-old boy developed a febrile illness characterized by brightly flushed cheeks and slight malaise, which was followed three days later, on March 31, 1963, by onset of a vesicular rash characteristic of chickenpox. The rash spread maximally within two days and gradually faded in association with recovery from illness. On April 6 febrile illness recurred, this time with considerable prostration, irritation of the eyes, and a dry hacking cough. On April 7 a rash appeared which, by the next day, was typical of measles. At this time (April 8) the crusted healing lesions of chickenpox were surrounded by zones of apparently normal
TCT-447 Predictors and clinical implications of stent thrombosis in patients with ST-segment elevation myocardial infarction. Insights from the EXAMINATION trial
Authors: Salvatore Brugaletta, Manel Sabate, Victoria Martin-Yuste, Monica Masotti, Angel Cequier, Armando Bethencourt, Josep Gomez Lara, Andres Iñiguez, Antonio Serra, Rosana Hernandez-Antolin, Marco Valgimigli, Vicente Mainar, Maurizio Tespili, Nicolas Vazquez, Peter den Heijer, Patrick W. Serruys
Journal: Journal of the American College of Cardiology (2013)