THE OPTIMAL DOSE OF MERCURIAL DIURETICS
Authors: Walter Modell
Journal: Annals of Internal Medicine (1944)

Article1 February 1944THE OPTIMAL DOSE OF MERCURIAL DIURETICSWALTER MODELL, M.D.WALTER MODELL, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-20-2-265 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptFatalities following the injection of mercupurin,1a phenomenon rarely reported in cardiac patients, stimulated interest in the problem of the safest effective dose of the mercurial diuretics. It has been suggested2that doses much larger than necessary are used, occasionally to the detriment of the patient. In New and Nonofficial Remedies,3the doses of merbaphen, mercupurin and salyrgan-theophyllin (each containing about 35 to 40 mg. of mercury per c.c.) are given as from 1 to 2 c.c. In Goodman and Gilman's textbook,4the same doses are advised. Similarly, Fishberg,5Levine,6and White7suggest doses of from 1 to 2 c.c....Bibliography1. BROWNFRIEDFELDKISSINMODELLSUSSMAN GLMWRM: Deaths immediately following the intravenous administration of mercupurin, Jr. Am. Med. Assoc., 1942, cxix, 1004. CrossrefGoogle Scholar2. Conferences on Therapy: The use of diuretics, New York State Jr. Med., 1942, xlii, 1092. Google Scholar3. New and Nonofficial Remedies, 1941, Am. Med. Assoc., Chicago. Google Scholar4. GOODMANGILMAN LA: The pharmacological basis of therapeutics, 1941, The Macmillan Co., New York. Google Scholar5. FISHBERG A: Heart failure, 1937, Lea and Febiger, Philadelphia. Google Scholar6. LEVINE SA: Clinical heart disease, 1941, W. B. Saunders Co., Philadelphia. Google Scholar7. WHITE PD: Heart disease, 1937, The Macmillan Co., New York. Google Scholar8. FOURNEAUMELVILLE EKI: Studies in mercurial chemotherapy, II. Jr. Pharmacol. and Exper. Therap., 1931, xli, 47. Google Scholar9. SOLLMANNSCHREIBER TNE: Comparative diuretic response to clinical injections of various mercurials, Arch. Int. Med., 1936, lviii, 1067. CrossrefGoogle Scholar10. BLUMGARTGILLIGANLEVYBROWNVOLK HLDRRCMGMC: Action of diuretic drugs. I. Action of diuretics in normal persons, Arch. Int. Med., 1934, liv, 40. CrossrefGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: *Received for publication September 17, 1942.From the Department of Pharmacology of Cornell University Medical College and the Cardiac Clinics of the Beth Israel Hospital and the Hospital for Joint Diseases, New York, N. Y. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byProblems in the Evaluation of Drugs in ManQuecksilberhaltige DiureticaA study of the effectiveness of mercurial diuretics in treatment of cardiac decompensationDiuretic Drugs in Congestive Heart FailurePresent Day Treatment of Congestive Heart FailurePathogenesis and Treatment of Salt and Water Retention in Congestive FailureA system for the routine treatment of the failing heart 1 February 1944Volume 20, Issue 2Page: 265-274KeywordsDiureticsEffective doseHeart diseasesHospitalsPharmacology ePublished: 1 December 2008 Issue Published: 1 February 1944 PDF downloadLoading ...