tbuckley/cabot-search huggingface dataset:
A formula for comparison of selected sport ball compressibility.
Authors: L J Dowell, G Krebs
Journal: British Journal of Sports Medicine (1991)

The purpose of this study was to develop a formula to determine and compare the compressibility of selected sport balls. Six balls (basketball, volleyball, soccer ball, baseball, handball, golf ball) were dropped ten times from each of four different heights onto a smooth solid surface overlaid with a white sheet of typing paper, overlaid with a sheet of carbon paper. The diameter of the area of contact of each ball imprinted onto the typing paper was measured in millimetres with calipers. From the data, the distance (d) that each ball compressed for each velocity (v) was calculated. It was found that a linear relationship existed between velocity at impact and the distance for each ball studied. The compressibility coefficient (c) for each ball was calculated and a formula was developed to determine the distance each ball would compress at a given velocity. When velocity is measured in metres per second and the distance a ball compresses is measured in millimetres, the formula to determine d for selected balls, in order of compressibility is: basketball d = 3.07v, volleyball d = 2.90v, soccer ball d = 2.80v, baseball d = 0.77v, handball d = 0.53v, and golf ball d = 0.17v.
Abstract 1095: Short Poly A sequence in HGF promoter region is involved in overexpression of HGF in cancer cells
Authors: Kazuko Sakai, Tokuzo Arao, Kazuko Matsumoto, Hideharu Kimura, Yoshihiko Fujita, Hiroyasu Kaneda, Daisuke Tamura, Keiichi Aomatsu, Kanae Kudo, Tomoyuki Nagai, Marco A. De Velasco, Isamu Okamoto, Kazuhiko Nakagawa, Kazuto Nishio
Journal: Cancer Research (2011)

Abstract Activation of the HGF-MET signaling increases invasion, metastasis and angiogenesis in cancer cells. Therefore, HGF-MET signaling is regarded as an oncogenic signaling pathway, and intensive therapeutic approaches focusing on this signaling pathway are ongoing in the field of cancer treatment. We previously reported that the concentration of serum HGF was strongly related with the treatment outcome of EGFR-tyrosine kinase inhibitors in patients with adenocarcinoma of the lung (Kasahara K. et al, Clin Cancer Res. 2010). Meanwhile, recent study has clearly demonstrated that HGF expression was regulated by short poly A sequence in its promoter region in breast cancer cells (Ma J. et al, J Clin Invest. 2009). In this study, we evaluated the poly A sequence in HGF promoter region and expression levels of HGF in 51 cancer cell lines. The five cell lines exhibited a short poly A sequence (16A-25A) in HGF promoter compared with wild-type (30A). Two of five cell lines overexpressed HGF at mRNA and protein expression levels determined by quantitative RT-PCR and ELISA. On the other hand, there were no HGF-overexpressing cell lines among 46 cell lines with wild-type poly A sequence. Of note, we have also detected the short poly A sequence in cancer cells in patients with lung cancer. Evaluation of short poly A, HGF expression and treatment outcomes of EGFR-tyrosine kinase inhibitors is under way. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 102nd Annual Meeting of the American Association for Cancer Research; 2011 Apr 2-6; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2011;71(8 Suppl):Abstract nr 1095. doi:10.1158/1538-7445.AM2011-1095
Myeloid leukemia after hematotoxins.
Authors: R A Larson, M M LeBeau, J W Vardiman, J D Rowley
Journal: Environmental Health Perspectives (1996)

One of the most serious consequences of cancer therapy is the development of a second cancer, especially leukemia. Several distinct subsets of therapy-related leukemia can now be distinguished. Classic therapy-related myeloid leukemia typically occurs 5 to 7 years after exposure to alkylating agents and/or irradiation, has a myelodysplastic phase with trilineage involvement, and is characterized by abnormalities of the long arms of chromosomes 5 and/or 7. Response to treatment is poor, and allogenic bone marrow transplantation is recommended. Leukemia following treatment with agents that inhibit topoisomerase II, however, has a shorter latency, no preleukemic phase, a monoblastic, myelomonocytic, or myeloblastic phenotype, and balanced translocations, most commonly involving chromosome bands 11q23 or 21q22. The MLL gene at 11q23 or the AML1 gene at 21q22 are almost uniformly rearranged. MLL is involved with many fusion gene partners. Therapy-related acute lymphoblastic leukemia also occurs with 11q23 rearrangements. Therapy-related leukemias with 11q23 or 21q22 rearrangements, inv(16) or t(15;17), have a more favorable response to treatment and a clinical course similar to their de novo counterparts.
Abstract 1116: Sleeping Beauty mutagenesis identifies genes and pathways that cooperate with BrafV600E in melanoma initiation and progression.
Authors: Michael B. Mann, Michael A. Black, Jerrold M. Ward, Marcus W. Bosenberg, Martin McMahon, Cristin G. Print, David J. Adams, Neal G. Copeland, Nancy A. Jenkins
Journal: Cancer Research (2013)

Abstract Malignant melanoma is a devastating disease the prevalence of which is on the rise. In humans, somatic mutation of BRAF, to encode the BRAFV600E oncoprotein, is an early predisposing event in melanoma initiation, but is insufficient to drive malignant melanomagenesis in the absence of additional cooperating events. We describe a genome-wide, forward genetic screen in mice restricted to pigment producing melanocytes as an unbiased approach to identify new candidate melanoma progression genes. By combining Sleeping Beauty (SB) with a Cre-activated BRafCA allele we observed frank melanomas with average latency of 36 weeks. By contrast, melanocyte specific expression of BRAFV600E elicited benign melanocytic nevi that failed to progress to malignant melanoma by one year of age. These findings confirm that SB mobilization altered genes that cooperate with BRAFV600E to promote melanoma progression. A discovery set of 1,200 statistically-defined candidate melanoma genes was identified from 70 SB|BRAFV600E tumors. Importantly, our screen identified seven SB mutated genes with human orthologs that are well established human melanoma drivers including: Cdkn2a, Pten, Gnaq, Mitf, Nf1, Rac1 and Ppp6c. Many biological signaling pathways and cellular processes were enriched for candidate melanoma genes altered in SB|BRAFV600E melanomas, including Wnt/Beta-catenin, TGFβ, PI3’-kinase and MAPK signaling pathways and biological processes regulating ubiquitin mediated proteolysis, tight junctions, cell cycle and axonal guidance. Integrated comparative oncogenomic analysis with human melanoma data sets provided a data-driven method to filter and prioritize candidate melanoma genes. The genes identified using the SB|BRAFV600E model may represent new human melanoma candidate cancer genes with potential clinical relevance to the progression and maintenance of human BRAF mutated melanoma. Citation Format: Michael B. Mann, Michael A. Black, Jerrold M. Ward, Marcus W. Bosenberg, Martin McMahon, Cristin G. Print, David J. Adams, Neal G. Copeland, Nancy A. Jenkins. Sleeping Beauty mutagenesis identifies genes and pathways that cooperate with BrafV600E in melanoma initiation and progression. [abstract]. In: Proceedings of the 104th Annual Meeting of the American Association for Cancer Research; 2013 Apr 6-10; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2013;73(8 Suppl):Abstract nr 1116. doi:10.1158/1538-7445.AM2013-1116
The SCOFF questionnaire: assessment of a new screening tool for eating disorders
Authors: J. F Morgan, F. Reid, J H. Lacey
Journal: BMJ (1999)

Eating disorders are among the most common psychiatric disorders in young women. Early detection and treatment improves prognosis, but presentation is often cryptic—for example, via physical symptoms in primary care. Ability to diagnose the condition varies and can be inadequate,1 and existing questionnaires for detection 2 3 are lengthy and may require specialist interpretation. No simple, memorable screening instruments are available for non-specialists. In alcohol misuse the CAGE questionnaire4 has proved popular with clinicians because of its simplicity. We developed and tested a similar tool for eating disorders— with questions designed to raise suspicion that an eating disorder might exist—before rigorous clinical assessment.

We developed five questions addressing core features of anorexia nervosa and bulimia nervosa using focus groups of patients with eating disorders and specialists in eating disorders; we tested the questions in a feasibility study of patients and staff at an eating disorders unit None …
Effect of tenidap on cartilage integrity in vitro.
Authors: J.T Dingle, M.R Leeming, J.J Martindale
Journal: Annals of the Rheumatic Diseases (1993)

The maintenance of articular cartilage integrity during long term treatment with non-steroidal anti-inflammatory drugs (NSAIDs) is of clinical importance. These experiments were set up to test the action of tenidap, naproxen, and diclofenac on bovine and porcine cartilage, matrix synthesis, and catabolism. Short term organ culture techniques were used to determine the effect of interleukin 1 (IL-1) on synthesis and degradation, and the action of tenidap and the other drugs on these parameters. The retention of glycosaminoglycans (GAGs) and the synthesis of GAGs by incorporation of sulphur-35 labelled sulphate was used to determine the chondrocyte metabolic activity. The action of human recombinant interleukin 1 alpha (hrIL-1 alpha) in increasing catabolic activity and inhibiting synthetic activity of the animal cartilages was confirmed. Tenidap was shown to give substantial and significant protection against the catabolic effects of hrIL-1 alpha and, to a lesser degree, against the inhibition of matrix synthesis by the cytokine. Neither diclofenac nor naproxen in doses expected to occur in the synovial fluid showed this action. Tenidap also inhibited the GAG loss from cocultures and, to a moderate degree, reversed the inhibition of synthesis by synovial tissue. Tenidap also stimulated cartilage repair activity during recovery from IL-1 treatment. The optimum concentration of the action against IL-1 was between 5 and 10 micrograms/ml. Above this concentration tenidap itself showed some inhibitory action on GAG synthesis. Bearing in mind the problems in extrapolating from in vitro work on animal cartilages to humans, it seems possible that tenidap may be useful in decreasing the deleterious action of cytokines such as IL-1 on cartilage integrity during arthritic disease and in stimulating chondrocyte repair processes.
Method for Measuring Capillary Permeability and its Use in Patients with Skin Disease
Authors: J. Marks, S. Shuster
Journal: BMJ (1966)

Alterations in capillary permeability in disease have not proved easy to measure.Methods used previously include measure- ment of haematocrit and plasma protein before and after a period of venous congestion (Landis, Jonas, Angevine, and Erb, 1932), measurement of disappearance from plasma of Evans blue (T 1824) (Weinbren, 1963) and 131I human serum albumin (Ismail, Khalifa, and Madwar, 1965), and simultaneous deter- mination of plasma volume by T 1824 and high-molecular- weight dextran (Verel, 1958).This is a report of a new method and of the findings obtained with it in patients with skin disease.
Comprehensive analysis of mRNA expression profiles in human respiratory epithelial cells after inoculation with respiratory syncytial virus*1
Authors: Y. Yamada, K. Matsumoto, N. Hashimoto, M. Saikusa, A. Kato, T. Homma, H. Saito, S. Yoshihara, O. Arisaka
Journal: Journal of Allergy and Clinical Immunology (2004)
Further Study of the Teeth of 5-year-old Children
Authors: M. Mellanby, H. Mellanby
Journal: BMJ (1951)

It was brought home to one of us in 1929, when examin- ing the teeth of some 5-year-old children in London County Council schools, that there was a great differ- ence between the condition of their teeth and those of children living in orphanages in the Midlands.Among the L.C.C. pupils at this time there were only 4.7 % * with caries-free or almost caries-free deciduous dentitions, whereas it was obvious at a glance that the number of orphanage children with caries-free teeth was much higher.In 1943 the chance arose of making a limited number of systematic inspections of the teeth of children living under different conditions.It was decided, in the first place, to see whether any changes had occurred in the teeth of L.C.C. pupils between 1929 and 1943.The imnprovement was so great (the 4.7% of 1929 had increased to 24.2% in 1943) that similar inspections were made in 1945, 1947, and 1949 (Mellanby and Coumoulos, 1944, 1946; Mellanby and Mellanby, 1948, 1950).It was not until 1945 that an opportunity arose of seeing whether there was any real connexion between living conditions and dental health in orphanage and L.C.C. children.Concurrently, a similar inquiry was made among pupils attending private (fee-paying) day schools; like the L.C.C. children, they lived with their own families.Meanwhile various workers had observed a tendency for children brought up in orphanages to suffer little from caries, while others, including Collett (1935) and Schiotz (1939) in Norway, and Anderson et al. (1934), in Toronto, had published a few figures relating to mixed age groups indicating that there was less caries among such children than among the general population.The threefold survey of 1945 (Coumoulos and Mellanby, 1947) showed that children living in homes had the worst dental structure, suggesting poor calcifying diets during tooth development, and yet had the least caries-less than the children of comparatively well-to-do families and much less than the L.C.C. group.It would have been instructive had we been able to parallel every survey in L.C.C. schools with similar inspections among residential homes and private-school children, but this was not possible.Early in 1950, however, the two groups in question were reinvestigated.This seemed especially urgent, since the present policy of boarding-out and adoption is removing nearly all 5-year-olds from homes.In this paper we are using the term " home " or " resi- dential home" to cover residential nurseries and schools administered by the State or by voluntary bodies; pre- viously we called them institutions.These are maintained *This figure of 4.70/r included children with up to three teeth with very slight caries (C, cavities) since the number of caries- free individuals was negligible.
MASSIVE DOSES OF PENICILLIN IN THE TREATMENT OF SUBACUTE BACTERIAL ENDOCARDITIS
Authors: Noyes L. Avery, Orlando B. Mayer, Robert C. Nelson
Journal: Annals of Internal Medicine (1946)

Case Reports1 May 1946MASSIVE DOSES OF PENICILLIN IN THE TREATMENT OF SUBACUTE BACTERIAL ENDOCARDITISNOYES L. AVERY JR., ORLANDO B. MAYER, ROBERT C. NELSONNOYES L. AVERY JR.Search for more papers by this author, ORLANDO B. MAYERSearch for more papers by this author, ROBERT C. NELSONSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-24-5-900 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptRecently an impressively high percentage of apparent cures in cases of subacute bacterial endocarditis has been reported by treatment with penicillin. In most of these cases the infecting organism has been aStreptococcus viridans. Some strains of this organism, unfortunately have been resistant to penicillin. We wish to report such a case which, although apparently incurable with rather large doses of penicillin, did respond favorably when massive doses of penicillin were employed in the presence of a renal blockage with diodrast and sodium p-aminohippurate. It should be noted that in this case, during the 17 month period in which various...Bibliography1. OSGOOD EE: Neoarsphenamine therapy of bacterial infections with a method of administration to maintain uniform blood levels for the treatment of serious staphylococcic infection and subacute bacterial endocarditis, Arch. Int. Med., 1942, lxix, 746-765. CrossrefGoogle Scholar2. RAMMELKAMPBRADLEY CHSE: Excretion of penicillin in man, Proc. Soc. Exper. Biol. and Med., 1943, liii, 30. CrossrefGoogle Scholar3. BEYERFLIPPINVERWEYWOODWARD KHHWFR: The effect of para-aminohippuric acid on the plasma concentration of penicillin in man, Jr. Am. Med. Assoc., 1944, lxxvi, 1007. CrossrefGoogle Scholar4. BEYERWOODWARDPETERSVERWEYMATTIS KHRLWFPA: The prolongation of penicillin retention in the body by means of para-aminohippuric acid, Science, 1944, p. 107. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: *Received for publication December 13, 1945. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byEmergence of Antibiotic-Resistant BacteriaPenicillin-resistant non-hemolytic streptococcal subacute bacterial endocarditisNew Concept of Competitive Inhibition of the Renal Tubular Excretion of PenicillinThe Treatment of Bacterial Endocarditis 1 May 1946Volume 24, Issue 5Page: 900-904KeywordsBloodEndocarditisExerciseHeartPenicillinSodiumStreptococcal infectionsStreptococcus ePublished: 1 December 2008 Issue Published: 1 May 1946 PDF downloadLoading ...
Neuregulin in Cardiac Hypertrophy in Rats With Aortic Stenosis
Authors: Susanne Rohrbach, Xinhua Yan, Ellen O. Weinberg, Faisal Hasan, Jozef Bartunek, Mark A. Marchionni, Beverly H. Lorell
Journal: Circulation (1999)

Neuregulins are a family of peptide growth factors that promote cell growth and viability. The potential role of neuregulin-erbB signaling in hypertrophic growth and later failure in the adult heart in vivo is not known.We used ribonuclease protection assays to quantify mRNA levels of neuregulin, erbB2, and erbB4 in left ventricular (LV) tissue and myocytes of normal rats and rats with aortic stenosis with pressure-overload hypertrophy 6 and 22 weeks after banding. At both stages of hypertrophy, Northern blot analyses of mRNA from LV myocytes showed upregulation of atrial natriuretic peptide, a molecular marker of hypertrophy (P<0.05). LV tissue neuregulin message levels were similar in animals with aortic stenosis compared with controls (P=NS) and were not detectable in myocytes. LV erbB2 and erbB4 message levels in LV tissue and myocytes were maintained during early compensatory hypertrophy in 6-week aortic stenosis animals compared with age-matched controls; in contrast, erbB2 and erbB4 message levels were depressed in 22-week aortic stenosis animals at the stage of early failure (both P<0.01 vs age-matched controls). Immunoblotting of erbB2 and erbB4 also showed normal protein levels in 6-week aortic stenosis animals compared with controls; however, erbB2 and erbB4 protein levels were depressed in 22-week aortic stenosis animals (48% decrease in erbB2, P<0.05, and 43% decrease in erbB4, P<0.01) relative to age-matched controls.The neuregulin receptors erbB2 and erbB4 are downregulated at both the message and protein levels at the stage of early failure in animals with chronic hypertrophy secondary to aortic stenosis. These data suggest a role for disabled erbB receptor signaling in the transition from compensatory hypertrophy to failure.
Magnifying endoscopic observation of mantle cell lymphoma in the stomach using the narrow-band imaging system
Authors: K. Nonaka, K. Ishikawa, S. Arai, M. Shimizu, T. Sakurai, M. Nishimura, M. Nakao, Y. Sasaki, H. Kita
Journal: Endoscopy (2010)

Multiple lymphomatous polyposis (MLP) is characterized by multiple polypoid tumors affecting several segments of the gastrointestinal tract due to involvement in Hodgkin’s or non-Hodgkin’s lymphoma [1] [2] [3]. The histologic picture of MLP is in most cases consistent with mantle cell lymphoma, but some patients with mucosa-associated lymphoid tissue lymphoma and follicular lymphoma presenting with MLP have recently been reported [4]. This is the first report of magnifying endoscopic observation of MLP using narrow-band imaging (NBI).
Oral antifungal agent effective even for widespread infections
Authors: William A. Check
Journal: JAMA (1980)

Evidence continues to amass on the effectiveness of the investigational drug ketoconazole in the treatment of both superficial and disseminated fungal infections (<i>JAMA</i>[MEDICAL NEWS] 1980;243:12). Amphotericin B also is efficacious, according to investigators, but chronic fungal infections often require long-term drug administration to prevent relapse. The advantage of ketoconazole is that it is an oral agent, in contrast to amphotericin B, which must be given intravenously and therefore necessitates a lengthy and expensive hospital stay. The most recent report, involving 12 consecutive patients with chronic mucocutaneous candidiasis, was given at the 20th Interscience Conference on Antimicrobial Agents and Chemotherapy in New Orleans. In a double-blind trial, Eskild A. Petersen, MD, and colleagues at the National Institute of Allergy and Infectious Diseases (NIAID) randomly allocated the patients to treatment with ketoconazole or an oral placebo. All but one had been afflicted for more than six years. The subjects were continued
Fatal mumps meningoencephalitis. Isolation of virus premortem and postmortem
Authors: B. Bistrian
Journal: JAMA (1972)

Mumps virus was recovered from both premortem cerebrospinal fluid and postmortem testicular tissue obtained from an 8-year-old boy with fatal meningoencephalitis. There was histologic evidence of both primary encephalitis with acute invasion of the central nervous system by virus and secondary postinfectious encephalitis with demyelination. With a safe and effective live, attenuated mumps vaccine available, a reappraisal of its place in immunization schedules is urged.
Sudden Death and Familial Occurrence of Midsystolic Click-Late Systolic Murmur Syndrome.
Authors: S. D. Shappell
Journal: Annals of Internal Medicine (1973)

Meeting Abstracts1 May 1973Sudden Death and Familial Occurrence of Midsystolic Click-Late Systolic Murmur Syndrome.S. D. Shappell, M.D., F.A.C.P., Charles E. Marshall, M.D., Ross E. Brown, M.D., Thomas A. Bruce, M.D., F.A.C.P.S. D. Shappell, M.D., F.A.C.P.Search for more papers by this author, Charles E. Marshall, M.D.Search for more papers by this author, Ross E. Brown, M.D.Search for more papers by this author, Thomas A. Bruce, M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-78-5-819_2 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe propositus, a 27-year-old white woman, had experienced five syncopal episodes since age 13. During excitement, she suffered cardiac arrest and was successfully resuscitated from ventricular fibrillation. Although her cardiovascular status was stable, she remained apneic and in coma. Her mother and grandmother had both died sudden, unexpected deaths when 32 and 40 years old, respectively. Examination at admission showed midsystolic click and late systolic murmur. Brain scan and EEG were negative. An ECG showed inverted T waves in leads II, III, aVF, and a QTc interval of 0.47 seconds. Control of cerebral edema led to ultimate restoration of near-normal... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Oklahoma City, Oklahoma PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 May 1973Volume 78, Issue 5Page: 819-819KeywordsBrainComaEdemaElectroencephalographyHeartSyncopeSystolic ejection murmurVentricular fibrillation Issue Published: 1 May 1973 PDF downloadLoading ...
Fabry disease mimicking hypertrophic cardiomyopathy: genetic screening needed for establishing the diagnosis in women
Authors: Ole Havndrup, Michael Christiansen, Birgitte Stoevring, Morten Jensen, Jakob Hoffman‐Bang, Paal Skytt Andersen, Lis Hasholt, Anne Nørremølle, Ulla Feldt‐Rasmussen, Lars Køber, Henning Bundgaard
Journal: European Journal of Heart Failure (2010)