THE CLINICAL SIGNIFICANCE OF HYPERGLOBULINEMIA. I. DIAGNOSTIC IMPLICATIONS
Authors: A R FEINSTEIN, R G PETERSDORF
Journal: Annals of Internal Medicine (1956)

Article1 May 1956THE CLINICAL SIGNIFICANCE OF HYPERGLOBULINEMIA. I. DIAGNOSTIC IMPLICATIONSALVAN R. FEINSTEIN, M.D., ROBERT G. PETERSDORF, M.D.ALVAN R. FEINSTEIN, M.D.Search for more papers by this author, ROBERT G. PETERSDORF, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-44-5-899 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptIn certain diseases the occurrence of hyperglobulinemia has been noted so frequently that the laboratory finding of an elevated serum globulin, without evident clinical explanation, will usually provoke an intensive diagnostic search for evidence of their presence. Among the conditions regularly associated with hyperglobulinemia are multiple myeloma, sarcoidosis, collagen disease, cirrhosis of the liver, kala-azar, lymphogranuloma venereum and certain other infections. The first three of these diseases in particular may often be unsuspected following routine clinical examinations, and are found only after the discovery of hyperglobulinemia gives the first clue leading to the diagnosis.At many hospitals the quantitative measurement...Bibliography1. GornallBardawillDavid AGCJMM: Determination of serum proteins by means of the biuret reaction, J. Biol. Chem. 177: 751, 1949. CrossrefMedlineGoogle Scholar2. CohnWolfson CWQ: Studies in serum proteins. II. A rapid clinical method for the accurate determination of albumin and globulin in serum or plasma, J. Lab. and Clin. Med. 33: 367, 1948. MedlineGoogle Scholar3. Howe PE: The use of sodium sulfate as the globulin precipitant in the determination of proteins in blood, J. Biol. Chem. 49: 93, 1921. CrossrefGoogle Scholar4. Dole VP: The electrophoretic patterns of normal plasma, J. Clin. Investigation 23: 708, 1944. CrossrefMedlineGoogle Scholar5. 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Author, Article, and Disclosure InformationAffiliations: New Haven, Connecticut*Received for publication November 18, 1955.From the Department of Medicine, Yale University School of Medicine, and the University Service of the Grace-New Haven Community Hospital, New Haven, Connecticut.†Present address: Columbia-Presbyterian Medical Center, New York, N. Y.‡Present address: The Johns Hopkins Hospital, Baltimore, Maryland. 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