tbuckley/cabot-search huggingface dataset:
Toxicity of Polychlorinated Biphenyl with Special Reference to Porphyrin Metabolism
Authors: S. Sano, S. Kawanishi, Y. Seki
Journal: Environmental Health Perspectives (1985)

Oral administration of a commercial PCB mixture to chickens caused a hepatic-type porphyria characterized by hepatic accumulation and urinary excretion of uroporphyrin. To clarify the mechanism of the porphyrinogenic activity of these PCBs, we studied the structural requirement of synthetic PCB for porphyrinogenic activities by using the cultured chick embryo liver cells and examined the relationship between induction of delta-aminolevulinic acid (ALA) synthetase and inhibition of uroporphyrinogen decarboxylase. We established that the porphyrinogenic effect of PCBs exhibits a sharply defined structure-activity relationship in that only 3,4,3',4'-tetrachlorobiphenyl and 3,4,5,3',4',5'-hexachlorobiphenyl produced a marked accumulation of uroporphyrin. We also demonstrated that in ALA-supplemented cultures, these same compounds lead to accumulation of a large amount of uroporphyrin III, whereas with other PCBs, which were weak inducers of porphyrin synthesis, the accumulated porphyrin was mostly protoporphyrin. was mostly protoporphyrin. Kinetic studies of the sequential decarboxylation of uroporphyrinogen with purified uroporphyrinogen decarboxylase were performed. The 3,4,3',4'-tetrachlorobiphenyl and 3,4,5,3',4',5'-hexachlorobiphenyl strongly inhibit uroporphyrinogen decarboxylase directly at two steps, i.e. first in the formation of hexacarboxylic porphyrinogen III from heptacarboxylic porphyrinogen III and second in the formation of heptacarboxylic porphyrinogen III from uroporphyrinogen III. The results confirmed that porphyrinogenic PCBs primarily inhibit uroporphyrinogen decarboxylase, leading to a depletion of heme as a result of which synthesis of ALA synthetase increased.
Public Health Policy on Varicella Infection
Authors: Stephen T. Green
Journal: JAMA (1990)

<h3>To the Editor.—</h3> Dr Johnson<sup>1</sup>suggested that early return of varicella-infected children to school would increase herd immunity and decrease the eventual incidence of varicella in adults. However, while Dr Bass'<sup>1</sup>reply stressed the potential risk to community-based immunosuppressed individuals of contracting chickenpox by secondary exposure, the failure to mention nonimmune pregnant women was a significant omission, as both mother and fetus are at risk of serious morbidity and mortality.<sup>2</sup>A maternal mortality rate of 40% has been reported,<sup>3</sup>and varicella, like any febrile condition, may lead to spontaneous abortion,<sup>4</sup>while a fetal varicella-related syndrome is recognized.<sup>5</sup> Pneumonitis is the main danger, especially among tobacco smokers,<sup>6</sup>and can progress to respiratory failure over a matter of hours.<sup>2</sup>Should pulmonary involvement be suspected, early recourse to high-dose intravenous acyclovir therapy (15 to 20 mg/kg of body weight three times daily)<sup>7</sup>and high-flow
Vascular Endothelial Cell Growth–Activated XBP1 Splicing in Endothelial Cells Is Crucial for Angiogenesis
Authors: Lingfang Zeng, Qingzhong Xiao, Mei Chen, Andriana Margariti, Daniel Martin, Aleksandar Ivetic, Heping Xu, Justin Mason, Wen Wang, Gillian Cockerill, Kazutoshi Mori, Julie Yi-shuan Li, Shu Chien, Yanhua Hu, Qingbo Xu
Journal: Circulation (2013)

Background— Vascular endothelial cell growth factor plays a pivotal role in angiogenesis via regulating endothelial cell proliferation. The X-box binding protein 1 (XBP1) is believed to be a signal transducer in the endoplasmic reticulum stress response. It is unknown whether there is crosstalk between vascular endothelial cell growth factor signaling and XBP1 pathway. Methods and Results— We found that vascular endothelial cell growth factor induced the kinase insert domain receptor internalization and interaction through C-terminal domain with the unspliced XBP1 and the inositol requiring enzyme 1 α in the endoplasmic reticulum, leading to inositol requiring enzyme 1 α phosphorylation and XBP1 mRNA splicing, which was abolished by siRNA-mediated knockdown of kinase insert domain receptor. Spliced XBP1 regulated endothelial cell proliferation in a PI3K/Akt/GSK3β/β-catenin/E2F2–dependent manner and modulated the cell size increase in a PI3K/Akt/GSK3β/β-catenin/E2F2–independent manner. Knockdown of XBP1 or inositol requiring enzyme 1 α decreased endothelial cell proliferation via suppression of Akt/GSK3β phosphorylation, β-catenin nuclear translocation, and E2F2 expression. Endothelial cell–specific knockout of XBP1 ( XBP1ecko ) in mice retarded the retinal vasculogenesis in the first 2 postnatal weeks and impaired the angiogenesis triggered by ischemia. Reconstitution of XBP1 by Ad-XBP1s gene transfer significantly improved angiogenesis in ischemic tissue in XBP1ecko mice. Transplantation of bone marrow from wild-type o XBP1ecko mice could also slightly improve the foot blood reperfusion in ischemic XBP1ecko mice. Conclusions— These results suggest that XBP1 can function via growth factor signaling pathways to regulate endothelial proliferation and angiogenesis.
Treatment of acute febrile neutrophilic dermatosis (Sweet's syndrome) with colchicine
Authors: Shoko Suehisa, Hachiro Tagami
Journal: British Journal of Dermatology (1981)

Journal Article Treatment of acute febrile neutrophilic dermatosis (Sweet's syndrome) with colchicine Get access Shoko Suehisa, Shoko Suehisa Department of Dermatology, Hamamatsu University School of Medicine, Hamamatsu, Japan Search for other works by this author on: Oxford Academic Google Scholar Hachiro Tagami Hachiro Tagami Department of Dermatology, Hamamatsu University School of Medicine, Hamamatsu, Japan Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 105, Issue 4, 1 October 1981, Page 483, https://doi.org/10.1111/j.1365-2133.1981.tb00785.x Published: 01 October 1981
Radioisotope Skeletal Survey
Authors: Gerald L. DeNardo
Journal: JAMA (1967)

A rapid, simple method for the detection of localized bone disease has been developed using a whole-body profile scanner and radioactive strontium (<sup>85</sup>Sr). In 49 patients with malignant neoplasm the method has proved to be more sensitive than photoscanning techniques and the roentgenographic skeletal survey. In this limited group of patients no profile scan was normal in the presence of bone involvement. No false-positive results occurred. This radioisotope method for surveying the skeleton is proposed as a routine screening procedure for the earlier detection of neoplastic bone disease.
The Sensitivity and Specificity of Nonmydriatic Digital Stereoscopic Retinal Imaging in Detecting Diabetic Retinopathy
Authors: Rajiv Raman, Padmaja Kumari Rani, Tarun Sharma
Journal: Diabetes Care (2007)

Ahmed et al. (1) concluded that nonmydriatic digital stereoscopic retinal imaging is a sensitive and specific method for the screening and diagnosis of diabetic retinopathy that may help improve compliance with the standards of eye care for patients with diabetes. This strategy seems to be a good option in a country like India, where the ophthalmologist-to-population ratio is estimated to be nearly 1:100,000 (2,3). The ratio is close to …
NAD(P)H:quinone oxidoreductase 1 NQO1*2 genotype (P187S) is a strong prognostic and predictive factor in breast cancer
Authors: Rainer Fagerholm, Barbara Hofstetter, Johanna Tommiska, Kirsimari Aaltonen, Radek Vrtel, Kirsi Syrjäkoski, Anne Kallioniemi, Outi Kilpivaara, Arto Mannermaa, Veli-Matti Kosma, Matti Uusitupa, Matti Eskelinen, Vesa Kataja, Kristiina Aittomäki, Karl von Smitten, Päivi Heikkilä, Jiri Lukas, Kaija Holli, Jirina Bartkova, Carl Blomqvist, Jiri Bartek, Heli Nevanlinna
Journal: Nature Genetics (2008)
Novel Cytotoxic Proteins of <i>Bacillus thuringiensis</i> Isolated from Peninsular India.
Authors: B. Devassy, T. Chubicka, G. Devaki, H. Nair, J. Padikala
Journal: Cancer Research (2009)

Abstract Bacillus thuringiensis (Bt) is a versatile soil born bacterium with potential insecticidal activity over a wide range of species of agriculture pests. These unusual properties are due to the crystal (Cry) inclusion proteins largely produced during the sporulation. Recent findings indicate that some non-insecticidal crystal inclusions are selectively cytotoxic to cancer cells. The toxicity is due to the induction of membrane permeability and apoptosis in susceptible cells. Recently, we have reported the cytotoxic effect of proteins extracted from three native strains of Bacillus thuringiensis from the Western Ghats of Kerala (India). Studies have shown that these potent toxins exhibit selective cytotoxicity against some human breast cancer cells including MCF-7, MDA-MB-231, ZR-75 and SKBR3. Presently, we report the cytotoxic properties of more number of Bacillus thuringiensis isolates from Peninsular India, which are already assessed for their diversity. The cytotoxic properties of isolates were primarily analysed by the amplification of DNA using specific primers designed for cytotoxic parasporal genes. The strains showing positive result were subjected to in vitro cytotoxic analysis using cancer cell lines. The crystal proteins were harvested from 72h old cultures in sporulating medium, after confirming the lysis of the cells and release of the protein. The cytotoxic proteins were isolated by aqueous biphasic (sodium dextran sulfate/polyethylene glycol) separation method and purified by various chromatographic (sephadex/nickel coated columns) and electrophoretic procedures. The molecular weight of proteins isolated from different isolates was varying and ranged from 15 to 80 kDa. The pro-protein isolated was activated and subjected in vitro cytotoxicity assay on various normal as well as breast cancer cell lines. The protein was found to have strong cytocidal activities against tumour cells and the treated cells showed remarkable morphological alterations and apoptotic cell death. Thus, a new 14 isolates were found to be cytotoxic by the study. The study revealed that the diversity of cytotoxic Cry genes in Peninsular India is perplexingly high and specific to certain cancers. Considering these results, we suggest that the receptor-mediated action of crystal proteins against tumour cells may find a new place in the therapeutic as well as diagnostic field of cancer therapy and the bacteria and its genetic potential may be utilized as versatile tools against cancer. Citation Information: Cancer Res 2009;69(24 Suppl):Abstract nr 3143.
The Physician Recognition Award
Authors: Donald W. Petit
Journal: JAMA (1970)

The American Medical Association has recently established a voluntary recognition award for physician participation in continuing education. The award is open to all physicians in the United States. For those physicians wishing to qualify, the requirements are 150 credit hours of continuing education in a period of three years, 60 hours or more made up of required educational activities, the remainder—up to 90 hours—of elective educational activities. The required education activities are accredited continuing education courses, papers or publications, and teaching. For the recent graduate of a medical school, internship-residency, education for an advanced degree, and research activities will quailify as required education activities. Elective education activities include such things as attendance at the scientific meetings of other national professional societies, local or regional scientific meetings, presentation of scientific exhibits, and additional teaching exercises. Details of the award may be obtained by writing to the Division of Medical Education, American
Landmark article Dec 1, 1906: Excision of cancer of the head and neck. With special reference to the plan of dissection based on one hundred and thirty-two operations. By George Crile
Authors: G. Crile
Journal: JAMA (1987)

Though signal advances have been made recently in many surgical problems, the treatment of cancer of the head and neck has, it would seem, neither received the attention nor kept the pace of progress in other fields. These unhappy cases are too often regarded as specters at the clinic. The operative treatment is hampered by tradition and conventionality, and the tragic ending of so large a proportion of these cases has held back lay and even professional confidence. In this paper it is intended to present an outline sketch of the conclusions regarding the surgical treatment of cancer of the head and neck in the curable stage. The etiology, the diagnosis and the pathology will not be considered. It is generally admitted that cancer is primarily a local disease. Each case, then, is presumably at some period curable by complete excision. The immediate extension from the primary focus is principally
A General Strategy for Dual‐Triggered Combined Tumor Therapy Based on Template Semi‐Graphitized Mesoporous Silica Nanoparticles
Authors: Yi Wang, Kaiyuan Wang, Xueying Yan, Rongqin Huang
Journal: Advanced Healthcare Materials (2013)

A general strategy is developed for dual-triggered chemo-photothermal tumor therapy based on template semi-graphitized mesoporous silica nanoparticles (TsGMSN). The strategy endues classic MSN with new charming properties, while easily escaping from toxicity of the surfactant. The doxorubicin-loaded system (TsGMSND) exhibits synergistic heat-stimulative, pH-responsive, and sustained release, and effective combined tumor therapy.
Long-Term Comparison of Endovascular and Open Repair of Abdominal Aortic Aneurysm
Authors: Frank A. Lederle, Julie A. Freischlag, Tassos C. Kyriakides, Jon S. Matsumura, Frank T. Padberg, Ted R. Kohler, Panagiotis Kougias, Jessie M. Jean-Claude, Dolores F. Cikrit, Kathleen M. Swanson
Journal: New England Journal of Medicine (2012)

Whether elective endovascular repair of abdominal aortic aneurysm reduces long-term morbidity and mortality, as compared with traditional open repair, remains uncertain.We randomly assigned 881 patients with asymptomatic abdominal aortic aneurysms who were candidates for both procedures to either endovascular repair (444) or open repair (437) and followed them for up to 9 years (mean, 5.2). Patients were selected from 42 Veterans Affairs medical centers and were 49 years of age or older at the time of registration.More than 95% of the patients underwent the assigned repair. For the primary outcome of all-cause mortality, 146 deaths occurred in each group (hazard ratio with endovascular repair versus open repair, 0.97; 95% confidence interval [CI], 0.77 to 1.22; P=0.81). The previously reported reduction in perioperative mortality with endovascular repair was sustained at 2 years (hazard ratio, 0.63; 95% CI, 0.40 to 0.98; P=0.04) and at 3 years (hazard ratio, 0.72; 95% CI, 0.51 to 1.00; P=0.05) but not thereafter. There were 10 aneurysm-related deaths in the endovascular-repair group (2.3%) versus 16 in the open-repair group (3.7%) (P=0.22). Six aneurysm ruptures were confirmed in the endovascular-repair group versus none in the open-repair group (P=0.03). A significant interaction was observed between age and type of treatment (P=0.006); survival was increased among patients under 70 years of age in the endovascular-repair group but tended to be better among those 70 years of age or older in the open-repair group.Endovascular repair and open repair resulted in similar long-term survival. The perioperative survival advantage with endovascular repair was sustained for several years, but rupture after repair remained a concern. Endovascular repair led to increased long-term survival among younger patients but not among older patients, for whom a greater benefit from the endovascular approach had been expected. (Funded by the Department of Veterans Affairs Office of Research and Development; OVER ClinicalTrials.gov number, NCT00094575.).
Rotational coronary ablation achieves lumen size comparable to balloon angioplasty without stretching the arterial wall
Authors: Scott L. Harris, Richard A. Staudacher, Jacques P. Heibig, Steven T. Minor, John M. Abukhalil, Neal S. Kleiman, Albert E. Raizner, Nadim M. Zacca
Journal: Journal of the American College of Cardiology (1991)
Effects of short-time tamoxifen therapy on breast cancer apoptosis and cell cycle regulators.
Authors: M Madeira, EC Millen, F Vivian, [F Logullo, LH Gebrim
Journal: Cancer Research (2009)

Abstract Abstract #3017 Background: Tamoxifen is the most used endocrine therapy in patients with estrogen and/or progesterone positive receptors breast cancer. Tamoxifen acts in a complex manner as estrogen antagonists in tumor tissue, and its interaction with growth factors may lead to inhibition of cell proliferation.&amp;#x2028; Objectives: The aim of this study was to evaluate the expression of estrogen receptor (ER), progesterone receptor (PR), COX-2, Ciclyn D-1, Bcl-2, BAK, BAX and nitric oxide synthase (NOS I, II and III) in breast carcinoma cells using immunohistochemical essay on tumor samples before and after short-time (14 days) exposure to tamoxifen.&amp;#x2028; Material and Methods: A randomized double-blind study was performed with 29 stage II and III breast cancer patients divided according to the following groups: Group C (n= 15 / control) and Group T (n=14 / 20mg of TAM/day for 14 days). Immunohistochemical expression of ER, PR, COX-2, Ciclyn D-1, Bcl-2, BAK, BAX and NOS I, II and III were evaluated before (diagnosis biopsy) and after treatment. The results were classified according Allred score (semi quantitative), based on the intensity and fraction marked cells. The scores of each reaction were compared pre and post treatment, and also to the control group.&amp;#x2028; Results: The mean scores of each reaction before and after treatment for Group T and Group C are seen in the table 1.&amp;#x2028; &amp;#x2028; No significant difference was observed with short-time tamoxifen therapy (table 2 - Mann Whitney test).&amp;#x2028; &amp;#x2028; Discussion: Although tamoxifen has been in clinical use for over 30 years in oncology, its complex manner of action is not totally elucidated. Our results did not show a significant change in breast cancer apoptosis and cell cycle regulators, but bring new data about the short-time exposure to tamoxifen. Citation Information: Cancer Res 2009;69(2 Suppl):Abstract nr 3017.
Prolonged Survival of Mice with Multiple Liver Metastases of Human Colon Cancer by Intravenous Administration of Replicable E1B-55K-Deleted Adenovirus with E1A Expressed by CEA Promoter
Authors: Tamotsu Sagawa, Minoru Takahashi, Tsutomu Sato, Yasushi Sato, Yue Lu, Tetsuya Sumiyoshi, Yasuyuki Yamada, Satoshi Iyama, Junki Fukaura, Katsunori Sasaki, Hirofumi Hamada, Koji Miyanishi, Tetsuji Takayama, Junji Kato, Yoshiro Niitsu
Journal: Molecular Therapy (2004)

Liver is the most preferential site for metastasis of colon cancer. We, in the present study, constructed a self-replicable adenovirus in which E1A is driven by a CEA promoter and E1B-55K is deleted from the E1B region (AdCEAp/Rep) and examined its effects on multiple metastases of a human colon cancer cell in a mouse xenograft model. We first showed effective replication of the virus in various CEA-producing human colon cancer cells (M7609, HT-29) and subsequent lysis of the infected cells in vitro. We then demonstrated that a single intratumoral injection of the virus (1 x 10(8) PFU/100 microl) induced a complete regression of subcutaneous tumors (M7609) inoculated into nude mice. Further, we demonstrated that systemic administration of the virus (1 x 10(8) PFU/100 microl) through the tail vein to nude mice, which 1 week prior had been inoculated with tumor cells (colon carcinoma cell line HT-29) via the spleen and showed apparent multiple metastases in the liver, effectively suppressed the metastasis formation. The mean survival time of the treated mice was significantly longer than that of the controls. Thus, the systemic administration of AdCEAp/Rep was considered to be effective on multiple liver metastases of CEA-positive colon cancer in a xenograft model.
TCT-650 Impact of the New BioMime™ Sirolimus-Eluting Stent in Comlex Patients of Daily Practice – Preliminary Results of the MeriT-2 Study
Authors: Erlon de Abreu-Silva, Ricardo Costa, Ashok Seth, Upendra Kaul, S.K. Mathew, Gurpreet Wander, Rohit Manoj, Mirela Lima, Suhas Hardas, Suresh Vijan, Ajit Mullasari, Thomas Alexander, Sunita Abraham, C.N. Manjunath, Prabhakar Shetty, Alexandre Abizaid
Journal: Journal of the American College of Cardiology (2012)
Psychiatric reactions to disaster: the Mount St. Helens experience
Authors: James H. Shore, Ellie L. Tatum, William M. Vollmer
Journal: American Journal of Psychiatry (1986)

Following the 1980 Mount St. Helens volcanic eruption, psychiatric reactions were studied in the disaster area and in a control community. Using the new criterion-based diagnostic method for psychiatric epidemiologic research, the Diagnostic Interview Schedule, the authors found a significant prevalence of disaster-related psychiatric disorders. These Mount St. Helens disorders included depression, generalized anxiety, and posttraumatic stress reaction. There was a progressive "dose-response" relationship in the comparison of control, low-exposure, and high-exposure groups. The dose-response pattern occurred among both the bereaved and the property-loss victims.