tbuckley/cabot-search huggingface dataset:
Questions on the Validity of Papers on Mitral Valve Prolapse and on Cardiomyopathy
Authors: Stephen Heymsfield, Linton C. Hopkins, Nanette K. Wenger, James F. Glenn, Candace L. Miklozek
Journal: Annals of Internal Medicine (1983)

Letters and Corrections1 August 1983Questions on the Validity of Papers on Mitral Valve Prolapse and on CardiomyopathySTEPHEN HEYMSFIELD, M.D., LINTON C. HOPKINS, M.D., NANETTE K. WENGER, M.D., JAMES F. GLENN, M.D., DEAN, CANDACE L. MIKLOZEK, M.D.STEPHEN HEYMSFIELD, M.D.Search for more papers by this author, LINTON C. HOPKINS, M.D.Search for more papers by this author, NANETTE K. WENGER, M.D.Search for more papers by this author, JAMES F. GLENN, M.D., DEANSearch for more papers by this author, CANDACE L. MIKLOZEK, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-99-2-275 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: In response to the announcement by Harvard University that John R. Darsee, M.D., had fabricated research data while serving as a research fellow in the Harvard School of Medicine, we initiated an extensive investigation by both internal and external committees of Dr. Darsee's work at Emory University. This letter concerns the article on ophthalmoplegia and mitral valve prolapse (1).Our recently concluded investigation was unable to identify all of the patients and the clinical data that formed the basis of this article. In view of our inability to verify Dr. Darsee's observations and the original data, as...Reference1. DARSEEMIKLOZEKHEYMSFIELDHOPKINSWENGER JCSLN. Mitral valve prolapse and ophthalmoplegia: a progressive cardioneurologic syndrome. Ann Intern Med. 1980;92:735-41. LinkGoogle Scholar1. DARSEENUTTER JD. Reversible severe congestive cardiomyopathy in three cases of hypophosphatemia. Ann Intern Med. 1978;89:867-70. LinkGoogle Scholar1. DARSEEMIKLOZEKHEYMSFIELDHOPKINSWENGER JCSLN. Mitral valve prolapse and ophthalmoplegia: a progressive cardioneurologic syndrome. Ann Intern Med. 1980;92:735-41. LinkGoogle Scholar2. DARSEENUTTER JD. Reversible severe congestive cardiomyopathy in three cases of hypophosphatemia. Ann Intern Med. 1978;89:867-70. LinkGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: STEPHEN HEYMSFIELD, M.D.; LINTON C. HOPKINS, M.D.; NANETTE K. WENGER, M.D.; JAMES F. GLENN, M.D., DEAN; CANDACE L. MIKLOZEK, M.D.Affiliations: PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byAnnals of Internal Medicine at Age 75: Reflections on the Past 25 YearsEdward J. Huth, MD and Kathleen Case, MSCardiomyopathyResponsibilities of CoauthorsKANTI R. RAI, M.D.Responsibilities of CoauthorshipUncertain Validity of Papers on Mitral Valve Prolapse with Ophthalmoplegia and on Cardiomyopathy with Hypophosphatemia 1 August 1983Volume 99, Issue 2Page: 275-276KeywordsCardiomyopathiesMitral valve prolapse ePublished: 1 December 2008 Issue Published: 1 August 1983 PDF downloadLoading ...
Effect of Elastic Compression on Venous Hemodynamics in Postphlebitic Limbs
Authors: Thomas F. O'Donnell
Journal: JAMA (1979)

To determine whether elastic compression alters the venous hemodynamics in the postphlebitic limb, we measured venous pressure patterns in 11 postphlebitic limbs with and without elastic compression stockings. Following cannulation of a dorsal vein of the foot, the patients underwent measurements of basal resting pressure, maximum percent decrease in venous pressure with exercise (delta VPex), peak systolic venous pressure during exercise (SVPmax), the amplitude of the pressure swing, and venous return time. Elastic compression did not alter basal resting pressure, delta VPex, or venous return time. By contrast, SVPmax decreased from 139 +/- 0.3 mm Hg to 11 +/- 8 mm Hg with elastic compression. If venous ulcers are related to the high pressure developed in the superficial veins during calf muscle systole, then elastic compression may be beneficial by decreasing systolic venous pressure and its subsequent deleterious consequences.
Systems biological analyses reveal the hepatitis C virus (HCV)‐specific regulation of hematopoietic development
Authors: Victoria M. Velazquez, Luke S. Uebelhoer, Manoj Thapa, Chris C. Ibegbu, Cynthia Courtney, Steven E. Bosinger, Joseph F. Magliocca, Andrew B. Adams, Allan D. Kirk, Stuart J. Knechtle, Daniel Kalman, Mehul S. Suthar, Arash Grakoui
Journal: Hepatology (2014)

Chronic liver disease is characterized by the liver enrichment of myeloid dendritic cells (DCs). To assess the role of disease on myelopoiesis, we utilized a systems biology approach to study development in liver‐resident cells expressing stem cell marker CD34. In patients with endstage liver disease, liver CD34+ cells were comprised of two subsets, designated CD34+CD146+ and CD34+CD146–, and hematopoietic function was restricted to CD34+CD146– cells. Liver CD34 frequencies were reduced during nonalcoholic steatohepatitis (NASH) and chronic hepatitis C virus (HCV) compared to alcohol liver disease (ALD), and this reduction correlated with viral load in the HCV cohort. To better understand the relationship between liver CD34+CD146+ and CD34+CD146– subsets and any effects of disease on CD34 development, we used gene expression profiling and computational modeling to compare each subset during ALD and HCV. For CD34+CD146+ cells, increased expression of endothelial cell genes including von Willebrand factor, VE‐cadherin , and eNOS were observed when compared to CD34+CD146– cells, and minimal effects of ALD and HCV diseases on gene expression were observed. Importantly for CD34+CD146– cells, chronic HCV was associated with a distinct “imprint” of programs related to cell cycle, DNA repair, chemotaxis, development, and activation, with an emphasis on myeloid and B lymphocyte lineages. This HCV signature was further translated in side‐by‐side analyses, where HCV CD34+CD146– cells demonstrated superior hematopoietic growth, colony formation, and diversification compared to ALD and NASH when cultured identically. Disease‐associated effects on hematopoiesis were also evident by phenotypic alterations in the expression of CD14, HLA‐DR, and CD16 by myeloid progeny cells. Conclusion : Etiology drives progenitor fate within diseased tissues. The liver may be a useful source of hematopoietic cells for therapy, or as therapeutic targets. (H epatology 2015;61:843–856)
Single-nucleotide polymorphism analysis of the multidrug resistance protein 3 gene for the detection of clinical progression in Japanese patients with primary biliary cirrhosis
Authors: Yuki Ohishi, Minoru Nakamura, Naomi Iio, Shingo Higa, Mao Inayoshi, Yoshihiro Aiba, Atsumasa Komori, Katsuhisa Omagari, Hiromi Ishibashi, Kazuhiro Tsukamoto
Journal: Hepatology (2008)

Primary biliary cirrhosis (PBC) is a multifactorial disease in which genetic factors rather than environmental factors may predominantly contribute to the pathogenesis. In order to identify the genetic determinants of the disease severity and progression of PBC, we examined an association of seven tag single-nucleotide polymorphisms (SNPs) in the multidrug resistance protein 3 (MDR3/ABCB4) gene in 148 Japanese PBC patients and 150 age- and sex-matched healthy control subjects. SNPs were detected via polymerase chain reaction (PCR) restriction fragment length polymorphism and PCR direct DNA sequencing methods. Subsequently, haplotypes were constructed from three tag SNPs (rs31658, rs31672, and rs1149222) that were significantly associated with progression of PBC. Logistic regression analyses revealed that a Hap 2 haplotype and its homozygous diplotype, Hap 2/Hap 2, in MDR3 were closely associated with the susceptibility to jaundice-type progression of PBC [P = 0.004, odds ratio (OR) 3.93, 95% confidence interval (CI) 1.56-9.90 and P = 0.0003, OR 17.73, 95% CI 3.77-83.42, respectively]. Conversely, another haplotype, Hap 1, and its homozygous diplotype, Hap 1/Hap 1, were associated with the insusceptibility to the progression to late-stage PBC (P = 0.021, OR 0.55, 95% CI 0.33-0.91 and P = 0.011, OR 0.24, 95% CI 0.08-0.71, respectively).The present study is the first report of an association of MDR3 haplotypes and diplotypes with progression of PBC. The Hap 2/Hap 2 diplotype in MDR3 could therefore be potentially applied to DNA-based diagnosis in Japanese patients with PBC as a strong genetic biomarker for predicting the progression and prognosis of PBC.
Cardiac Arrhythmias: Self-Learning
Authors: Samuel Zoneraich
Journal: JAMA (1987)

In this informative volume, the author reviews the electrocardiograms of patients with common cardiac arrhythmias encountered by the physician, medical student, and nurse. Modern cardiology has become a realm of spectacular diagnostic and surgical techniques. In the wide field of cardiac arrhythmias, impressive diagnostic laboratories replete with expensive and sophisticated equipment are now in existence in many medical centers. In daily practice, however, electrocardiographic diagnosis continues to depend on the skill and experience of the electrocardiographer and on the ability to relate findings to clinical experience. From this standpoint, interpretation of the surface electrocardiogram continues to be an art. The strength of the book lies in its practical approach to the interpretation of various arrhythmias, based on the well-known teaching technique of "self-learning." In many cases, the author also notes the pertinent clinical significance and therapeutic approach in a concise manner. Overall, the text accomplishes the goal of providing a
Comments on Baker's “Draft Model Aggregated Code of Ethics for Bioethicists”
Authors: Michael Davis
Journal: The American Journal of Bioethics (2005)

of ethics can justify discipline or legal liability. So, for example, once a profession has a formal code of ethics, courts can appeal to it when deciding what reasonable care in that profession is. The code’s higher (more demanding) standard may, and should, replace the standard common sense would 25 otherwise set. A code of ethics should be designed with all these purposes in mind—if only to state expressly that the code should be used in such-and-such ways but not in others. The preamble is a good place for such a statement. I think Baker’s Preamble (2005) should say more than it does 30 about how the code should be used.
Understanding the Complexity of Homocysteine Lowering With Vitamins
Authors: J. David Spence, Meir J. Stampfer
Journal: JAMA (2011)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Artemether in Severe Malaria — Still Too Many Deaths
Authors: Stephen L. Hoffman
Journal: New England Journal of Medicine (1996)

The impact of malaria is almost inconceivable to those who do not live in the tropics or subtropics. Each year, there are 300 million to 500 million new plasmodium infections and 1.5 million to 2.7 million deaths from malaria in the developing world. Since 1981 there have been an estimated 2.5 million deaths caused by infection with the human immunodeficiency virus worldwide, as compared with 20 million to 40 million deaths caused by malaria. Malaria is a major threat to travelers, and the U.S. military has had more casualties from malaria than from bullets in every campaign of the 20th . . .
Expansion of human bone marrow stromal cells on poly-(dl-lactide-co-glycolide) (PDLLGA) hollow fibres designed for use in skeletal tissue engineering
Authors: Suzanne M. Morgan, Simon Tilley, Semali Perera, Marianne J. Ellis, Janos Kanczler, Julian B. Chaudhuri, Richard O.C. Oreffo
Journal: Biomaterials (2007)
Systemic Absorption of Orally Administered Neomycin in Liver Disease
Authors: Peter M. Last, Sheila Sherlock
Journal: New England Journal of Medicine (1960)

NEOMYCIN was introduced by Waksman and Lechevalier1 as an antibiotic active against organisms resistant to streptomycin. It was first given to patients with intractable tuberculosis or urinary infections, but was found to damage readily the kidney, the eighth nerve and possibly the liver.2 3 4 Waisbren and Spink5 gave neomycin parenterally to 63 patients and found evidence of transient renal damage in 24 cases, and 5 patients became deaf. At autopsy in their fatal cases, as in those of others,6 7 8 9 the kidneys showed severe tubular necrosis. Some of these authors also reported permanent perception deafness and occasionally vestibular damage; these sometimes developed . . .
Possible Explanation of Appearance of Warthin??s Tumor on I-123 and Tc-99m-Pertechnetate Scans
Authors: ASLAM R. SIDDIQUI, EDWARD C. WEISBERGER
Journal: Clinical Nuclear Medicine (1981)

A 71-year-old man presented with a parotid mass and a thyroid nodule. An 1–123 scan revealed a “cold” nodule in the thyroid and uptake of the radioactive iodine in the parotid mass. On a Tc-99m-pertechnetate salivary gland scan, the parotid mass was “hot” and did not wash out with sodium perchlorate. At surgery, he was found to have a Warthin's tumor of the parotid gland and an adenomatous goiter. The reasons for the scan appearance of the Warthin's tumor are discussed. Since Warthin's tumors are benign and uptake of radioactive iodine in the extrathyroidal deposits of thyroid carcinoma is rare with the thyroid gland in place, the uptake of iodine by a salivary gland mass probably indicates a benign process.
Tuberculosis control in Europe and international migration
Authors: HL Rieder, JP Zellweger, MC Raviglione, ST Keizer, GB Migliori
Journal: European Respiratory Journal (1994)

This is a consensus-based position paper of a Task Force, comprising representatives of nongovernmental and governmental organizations in the European Region of the International Union Against Tuberculosis and Lung Disease and the World Health Organization, on tuberculosis control in the countries of Europe and international migration. Tuberculosis among the foreign population entering European countries represents an increasing and important proportion of all tuberculosis cases reported in these countries. Adequate surveillance systems allow the identification of population segments at an excess risk of tuberculosis compared to the general population. Among groups of foreigners with a risk considerably exceeding that of the general population, screening for tuberculosis and infection with M. tuberculosis yields a large number of persons in many countries who can benefit from curative and preventive interventions. The Task Force recommends that European countries: 1) have notification systems based on both mandatory laboratory and physician reports of tuberculosis cases, to allow identification of population segments at an excess incidence of tuberculosis compared to the general population; 2) consider screening of high incidence and prevalence groups among the entering foreign population for tuberculosis and infection with M. tuberculosis amenable to curative and preventive i intervention; 3) utilize existing governmental and nongovernmental organizations to provide culturally and socially sensitive services to ensure proper follow-up and implementation of interventions; 4) provide comprehensive curative and preventive services to treat tuberculosis; and 5) evaluate efficiency and efficacy of screening procedures on an ongoing basis.
Thrombocytopenic Purpura Complicating Arsenobenzene Therapy
Authors: S. M. Laird
Journal: BMJ (1942)

must not be allowed to give rise to a false sense of security, and every possible care should be taken in handling material containing it.Summary Methods used for the production of human plasma and serum on a large scale are described.Plasma is separated either by an Alfa-Laval separator or by suction after the cells have settled.It is then pooled in 10- litre bottles for convenience in handling.Serum is separated by various methods at the blood supply depots and is sent to us in bulk for filtration and bottling.The plasma and serum are clarified by passage through sterile paper pulp and are then sterilized by Seitz filtration.Technical details are given of the methods employed to pre- vent contamination during the various stages of preparation and to ensure sterility of the final products.Methods similar to the above have been used in and de- scribed from various laboratories.In the early days of the work information was freely exchanged between Dr. R. I. N. Greaves, Dr. W. S. Stanbury, Colonel L. E. H. Whitby, and our- selves, and it is impossible always to establish where particular processes originated.Bushby and Whitby (1941) have published an account of a similar procedure, but it was thought that a description of our methods might be of interest.
Ketamine Prevention of Penile Turgescence
Authors: Arnold S. Gale
Journal: JAMA (1972)

<h3>To the Editor.—</h3> Cystoscopy and operative procedures on the penis can be rendered difficult, if not impossible, if an erection occurs. Since the latter is not uncommon, in spite of general and even regional anesthesia, a method to prevent or reverse this condition would be helpful. Since the turgescence seems to occur in response to external stimuli, it was thought that a dissociative anesthetic such as ketamine might prevent such a response. A limited number of patients (25) were given a does of 1 mg/lb of body weight at the time of induction. Anesthesia was induced and maintained in the usual manner with thiopental and nitrous oxide with a narcotic (anileridine) or halothane. In no case did an erection occur, even though only a single dose of ketamine was administered and the procedure lasted an hour or more. In two additional cases, the same dose of ketamine was administered after
Poor long term outcome of severe alopecia areata in children treated with high dose pulse corticosteroid therapy
Authors: T. Hubiche, C. Léauté-Labrèze, A. Taïeb, F. Boralevi
Journal: British Journal of Dermatology (2008)

Conflicts of interest: none declared. Sir, Alopecia areata (AA) occurring before puberty is associated with a poorer prognosis than adult AA.1, 2 It is more likely to have a chronic evolution and to worsen over time.2 Treatment with boluses of methylprednisolone (MPBT) is currently used to treat this T‐cell mediated auto‐immune disease. It is considered as an effective and well‐tolerated treatment for extensive patchy AA.3 However, despite the tendency for a chronic evolution of AA occurring before puberty, long‐term assessment of this therapy to the best of our knowledge has not been reported. The objective of this cross sectional study was to assess the long‐term effectiveness of MPBT on severe AA occurring before puberty. The 12 consecutive patients aged between 1 and 16 years who had been treated with MPBT between January 1999 and December 2005 were asked to come for a visit. The treatment was done according to Kiesch et al.4 All patients were systematically examined before and one month after the end of the therapy. Long‐term assessment was carried out between January 2006 and March 2007. The short term and long term outcomes were measured according to the following criteria: good if regrowth was better than 60%, moderate if between 30 and 60% and bad below 30%, when compared to baseline photographs obtained at the first MBPT course.
NMS Review for the USMLE Clinical Skills Exam
Authors: Victoria Wong
Journal: JAMA (2007)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Lipid peroxidation and antioxidative protection mechanism in rat lungs upon acute and chronic exposure to nitrogen dioxide.
Authors: M Sagai, T Ichinose
Journal: Environmental Health Perspectives (1987)

This work was done to clarify the relation between the changes of lipid peroxidation and the activities of antioxidative protective enzymes in lungs of rats exposed acutely, subacutely, and chronically to nitrogen dioxide. It was confirmed that the activities of the antioxidative enzymes to protect cells from oxidative stress increased in an early phase, and then the activities decreased gradually. Lipid peroxides increased once in an early phase and then returned to the control level; thereafter, lipid peroxides increased gradually again. Lipid peroxidation as measured by ethane exhalation increased significantly with 0.04, 0.4, and 4 ppm nitrogen dioxide exposure for 9, 18, and 27 months, and a dose-response relationship was clearly observed. The temporal changes of lipid peroxidation varied inversely with that of the activities of antioxidative protective enzymes. From these results, it was suggested that the increments of antioxidative protective enzyme activities in an early phase were complementary effects to protect cells from damage by lipid peroxides which were increased by nitrogen dioxide exposure, and that the complementary effects are lost in later phases of life-span exposure. Finally, loss of such protective complementary effects might relate to some chronic diseases in lungs. Therefore, the temporal changes described above are important characteristics in chronic exposure of air pollutants.