Familial Mediterranean Fever
Authors: SHERMAN M. MELLINKOFF
Journal: Annals of Internal Medicine (1962)

Article1 February 1962Familial Mediterranean FeverPlasma Protein Abnormalities, Low-fat Diet, and Possible Implications in PathogenesisSHERMAN M. MELLINKOFF, M.D., F.A.C.P., RICHARD W. SNODGRASS, M.D., ARTHUR D. SCHWABE, M.D., JAMES F. MEAD, PH.D., HENRY E. WEIMER, PH.D., MARJORIE FRANKLAND, A.B.SHERMAN M. MELLINKOFF, M.D., F.A.C.P.Search for more papers by this author, RICHARD W. SNODGRASS, M.D.Search for more papers by this author, ARTHUR D. SCHWABE, M.D.Search for more papers by this author, JAMES F. MEAD, PH.D.Search for more papers by this author, HENRY E. WEIMER, PH.D.Search for more papers by this author, MARJORIE FRANKLAND, A.B.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-56-2-171 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptClinical and laboratory features of familial Mediterranean fever have been described by many authors (1-5). A comprehensive and thoughtful analysis of the medical problem and clarification of terminology in the world-wide literature were provided in 1958 by Heller, Sohar, and Sherf (1), stimulating renewed interest in this disease.In brief, the patients are almost always of Mediterranean ancestry and inherit a tendency to suffer from recurrent short attacks of fever, usually accompanied by peritonitis, pleuritis, arthritis, or dermatitis (6). Ultimately a large number develop amyloidosis, which is apparently not well correlated with the duration or frequency of the febrile episodes...References1. HELLERSOHARSHERF HEL: Familial Mediterranean fever. Arch. Intern. Med. 102: 50, 1958. CrossrefGoogle Scholar2. EHRENFELDELIAKIMRACHMILEWITZ ENMM: Recurrent polyserositis (familial Mediterranean fever; periodic disease), a report of fifty-five cases. Amer. J. Med. 31: 107, 1961. CrossrefGoogle Scholar3. MARMORCATTAN HR: La maladie periodique (sur 13 cas personnels dont 8 compliques de nephropathies). Sem. Hop. Paris 28: 1062, 1952. MedlineGoogle Scholar4. REIMANN HA: Periodic disease; probable syndrome including periodic fever, benign paroxysmal peritonitis, cyclic neutropenia, and intermittent arthralgia. J. A. M. A. 126: 239, 1948. CrossrefGoogle Scholar5. SIEGAL S: Benign paroxysmal peritonitis. Ann. Intern. Med. 23: 1, 1945. LinkGoogle Scholar6. SOHARPRASSHELLERHELLER EMJH: Genetics of familial Mediterranean fever. Arch. Intern. Med. 107: 529, 1961. CrossrefGoogle Scholar7. SOHARGAFNIHELLER EJJ: Amyloidosis in familial Mediterranean fever. Arch. Intern. Med. 107: 539, 1961. CrossrefMedlineGoogle Scholar8. BONDYCOHNCASTIGLIONE PKGLC: Etiocholanolone fever. A clinical entity. Trans. Ass. Amer. Physicians 73: 186, 1960. Google Scholar9. COHNBONDYCASTIGLIONE GLPKC: Studies on pyrogenic steroids. I. Separation, identification, and measurement of unconjugated dehydroepiandrosterone, etiocholanolone, and androsterone in human plasma. J. Clin. Invest. 40: 400, 1961. CrossrefMedlineGoogle Scholar10. MELLINKOFFSCHWABELAWRENCE SMADJS: A dietary treatment for familial Mediterranean fever. Trans. Ass. Amer. Physicians 73: 197, 1960. Google Scholar11. FILLERUPMEAD DLJF: Chromatographic separation of plasma lipids. Proc. Soc. Exp. Biol. Med. 83: 574, 1953. CrossrefMedlineGoogle Scholar12. WEIMERMOSHIN HEJR: Serum glycoprotein concentrations in experimental tuberculosis in guinea pigs. Amer. Rev. Tuberc. 68: 31, 1953. Google Scholar13. STEYERMARK A: Quantitative Organic Microanalysis, The Blakiston Division, McGrawHill Book Co., Inc., New York, 1951, ch. 9. Google Scholar14. LAWRENCEWEIMERSALKIN SHHED: Serial electrophoretic studies of the serum glycoproteins and proteins in patients with pulmonary tuberculosis. Clin. Chim. Acta 4: 374, 1959. CrossrefMedlineGoogle Scholar15. FISHER RA: Statistical Methods for Research Workers, 12th ed., Hafner Publishing Co., Inc., New York, 1954. Google Scholar16. KINGSLEY GR: Unpublished observations. Google Scholar17. SCHJEIDE OA: Personal communication. Google Scholar18. SINZLER RJ: The Plasma Proteins. Vol. I. Isolation, Characterization, and Function, ed. by Putnam, F. W., Academic Press, New York and London, 1960, ch. 9. Google Scholar19. ROBERTS S: Personal communication. Google Scholar20. HSIA DY: Medical genetics. New Engl. J. Med. 262: 1172, 1960. CrossrefMedlineGoogle Scholar21. KAPPASSOYBELFUGUSHIMAGALLAGHER AWDKTF: Studies on pyrogenic steroids in man. Trans. Ass. Amer. Physicians 72: 54, 1959. Google Scholar22. PALMERGLICKMANKAPPAS RHPBA: Unpublished observations. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Los Angeles, CaliforniaFrom the Departments of Medicine, Physiological Chemistry and Infectious Diseases, Medical School, University of California at Los Angeles, Los Angeles, California.Supported by grant A-4625 from the United States Public Health Service.Requests for reprints should be addressed to Sherman M. Mellinkoff, M.D., University of California Medical CenterLos Angeles 24, California. 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WESTFALL, M.D.Primary systemic amyloidosis simulating acute idiopathic ulcerative colitisFamilial paroxysmal polyserositisSynovial fluid lipids in normal individuals and patients with rheumatoid arthritis 1 February 1962Volume 56, Issue 2Page: 171-182KeywordsAmyloidosisBlood plasmaClinical laboratoriesFeversInfectious diseasesLipoproteinsMedical servicesPeritonitisProteinsResearch laboratories Issue Published: 1 February 1962 CopyrightCopyright ©, 1962, by The American College of PhysiciansPDF DownloadLoading ...