tbuckley/cabot-search huggingface dataset:
Abstract 19298: Is the Seasonal Variation in Acute Aortic Dissection Occurrence Associated with Flu Activity?
Authors: Harleen K Sandhu, Kristofer M Charlton-Ouw, Samuel S Leake, Ali Azizzadeh, Tom C Nguyen, Anthony L Estrera, Hazim J Safi, Charles C Miller
Journal: Circulation (2014)

Introduction: Numerous reports have described seasonal patterns of acute aortic dissection (AAD), but reasons for such patterns are unknown. Correlations between cardiovascular morbidity and seasonal influenza have also been described. Methods: We compared monthly admissions for AADs at our institution to the US seasonal influenza activity based on US Centers for Disease Control statistics over 13 years. Seasonal variation was modeled by autoregressive integrated moving average (ARIMA) analysis, and multivariate effects of season and influenza activity on aortic dissection admissions were assessed by response surface regression. Results: From January 2001 to December 2013, we treated 869 patients with AAD (398 type A, 442 typical type B, 29 type B variants). Admissions for AAD were identified as highest during the months of November to March (high period-HP). For type A AAD, 3.1 cases per month were admitted during HP, compared to 2.1 cases per month for the remainder of the year (p&lt;0.002). Type B AADs averaged 3.2 cases/month during the HP compared to 2.9 cases/month for the remainder of the year (p=0.40). Influenza activity averaged 2.6% during HP compared to 1.1% in the remaining months (p&lt;0.0001). ARIMA models for AAD over the entire 156 month observation period showed statistically significant seasonality (p&lt;0.0001), and smoothed spline plots showed type A dissection and flu activity moving cyclically and generally in synchrony throughout the period (fig 1). Response surface regression demonstrated significant effects of flu activity (p&lt;0.034) and month of the year (p&lt;0.048) on the rate of AAD occurrence at our center. Conclusion: Presentation of AAD to our center and seasonal influenza activity in the US were both elevated during the HP, and were significantly correlated. Type A AAD significantly correlated with season or flu activity while Type B did not. Seasonal flu vaccination among high risk patients may be appropriate
Distal digital keratoacanthoma: a report of 12 cases and a review of the literature
Authors: None Baran, None Goettmann
Journal: British Journal of Dermatology (1998)

Twelve cases of distal digital keratoacanthoma (DKA) affecting the subungual area or the proximal nail fold are reported. The distal phalanx of the toe was affected in three cases. Spontaneous resolution occurred in one; one other recurred after surgery. We also discuss the link between DKA and incontinentia pigmenti subungual tumours; these entities are indistinguishable.
Spring on the Missouri
Authors: M. Therese Southgate
Journal: JAMA (2002)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Abstract 2767: Identification of kinase fusion genes in bladder cancer through kinome-centered RNA sequencing
Authors: Floris Groenendijk, Iris de Rink, Laura Mertens, Annegien Broeks, Yann Neuzillet, Jeroen de Jong, Bas van Rhijn, Rene Bernards, Michiel van der Heijden
Journal: Cancer Research (2014)

Abstract Urothelial carcinoma (UC) of the bladder is one of the most common cancers worldwide. The treatment of patients with metastatic or locally advanced UC consists of platinum-based chemotherapy. Unfortunately, a large number of patients will ultimately develop resistance. Therapeutic options at that point are very limited: the last FDA drug approval for the treatment of bladder cancer dates back more than 2 decades. Identification of activated signaling pathways in UC can provide new targets for treatment. Recent DNA and RNA sequencing projects in invasive UC have revealed somatic mutations in several cancer genes. Some of these mutated genes, such as FGFR3 and PIK3CA, could potentially guide therapy. However, our knowledge of gene rearrangements in bladder cancer remains limited. These fusion genes often involve multiple fusion partners, as was reported for FGFR3 fusions in bladder cancer, which represents a significant challenge for discovery and for subsequent diagnostic screening. Therefore, a global detection method is needed to fully understand the diversity of alterations driving this disease. We used a high-throughput platform to systematically profile kinase fusions through specific enrichment of kinase transcripts. Using this approach, we screened 80 muscle invasive UC specimens and identified a number of activating mutations and novel fusion transcripts. The fusion genes identified in this discovery set will be validated in a second cohort of UC specimens to determine their frequency. Functional validation will be presented for some of these fusion genes. These genetic alterations may provide new avenues for individualized molecular treatment of UC patients. Citation Format: Floris Groenendijk, Iris de Rink, Laura Mertens, Annegien Broeks, Yann Neuzillet, Jeroen de Jong, Bas van Rhijn, Rene Bernards, Michiel van der Heijden. Identification of kinase fusion genes in bladder cancer through kinome-centered RNA sequencing. [abstract]. In: Proceedings of the 105th Annual Meeting of the American Association for Cancer Research; 2014 Apr 5-9; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2014;74(19 Suppl):Abstract nr 2767. doi:10.1158/1538-7445.AM2014-2767
Abstract 3989: Novel Role of CHIP E3 Ubiquitin Ligase, C-terminus of Hsp70-interacting Protein, on Myocyte Apoptosis via ERK5-mediated Destabilization of Inducible Camp Early Repressor (ICER)
Authors: Changhoon Woo, Hiroki Takahashi, Tetsuro Shishido, Carolyn McClain, Thomas Spangenberg, Chen Yan, Cam Patterson, Jun-ichi Abe
Journal: Circulation (2009)

Apoptosis plays a critical role in cardiac dysfunction after myocardial infarction (MI), and emerging evidence suggested the critical role of ICER in this process. Previously, we found that PKA act...
Role of SUMOylation in alternative lengthening of telomeres in cancer
Authors: Jacklyn Yong, M. Hande, Martin Lee
Journal: Clinical Cancer Research (2007)

B77   Small Ubiquitin-like Modifier (SUMO) proteins are involved in reversible post-translational modifications of proteins, termed SUMOylation. SUMO modification of a protein affects its stability, cellular localisation and protein-protein interaction. Additionally, SUMOylation of transcription factors may either increase or decrease their transcriptional activity. Tumour suppressor p53 is a transcription factor that is modifiable by SUMO. In our study, we are looking at the effects of enhancing SUMOylation in primary jejunal cells, JFCF-6/T.1R - which exhibits the Alternative Lengthening of Telomeres (ALT) phenotype. Cells with such phenotype are able to maintain and/or elongate their telomeres in the absence of telomerase and display a unique type of PML nuclear bodies containing telomeres and its associated proteins. In this study, we have shown that p53 is modifiable by SUMO in JFCF-6/T.1R and the SUMOylated levels of p53 are influenced by the stage of the cell cycle. Treatment of JFCF-6/T.1R with sodium arsenite showed reduction in the levels of SUMOylated proteins, including that of p53. We have demonstrated too that by over-expressing SUMO1 and certain SUMO E3 ligases such as PIAS, levels of SUMO-p53 can be increased. As SUMOylation of the PML protein is a prerequisite for PML bodies formation, we speculate that by manipulating the SUMOylation environment in ALT cells, we could interfere with the ALT pathway of telomere maintenance.
Abstract 15562: Impact of Off-time Presentation on the Vulnerability of the Culprit Lesions in ST-elevation Acute Myocardial Infarction
Authors: Young Kim, Sang Wook Kim, Wang Soo Lee, Hoyoun Won, Seong Hyeop Hyeon, Jee Eun Kwon, Yoon Sang Chung, Seung Yong Shin, Kwang Je Lee, Tae Ho Kim, Chee Jeong Kim
Journal: Circulation (2014)

Background: ST-elevation myocardial infarction (STEMI) that occurs during the off hours shows worse clinical status compared to the patients presenting during working hours. Method: We used Virtual Histology Intravascular Ultrasound (VH-IVUS) to assess the complexity of culprit lesion in 193 patients with STEMI. The patients were divided into two groups that presented to the hospital during the working hours (from 8:30 am to 6:00 pm) and the off hours (from 6:00 pm to 8:30 am of the next day). VH-TCFA (thin-capped fibroatheroma) was defined as necrotic core (NC) &gt;10% of plaque area with a plaque burden of &gt;40% and NC in contact with the lumen for ≥3 image slices. Positive remodeling was a remodeling index (lesion/reference EEM [external elastic membrane] area) &gt;1.05. Result: 91(46.0%) pts were visited during working hours, and 102(54.0%) pts during the off hours. Pt age was 60±13 yr in working hour STEMI and off hour STEMI was 61±10 yr. The lesion length, vessel size and minimal lumen area (MLA) were similar. The average and maximum necrotic core area of the off hours STEMI were larger than the working hours STEMI(p=0.025 and p=0.005 respectively). The remodeling index at maximum necrotic core site was also higher in the off hours STEMI than the working hours group respectively (p=0.042). Positive remodeling was 42.9%(39/91) in working hour STEMI and 59.8%(61/102) in off hour STEMI (p=0.028). However, the frequency of TCFA was similar in both group(25.7% vs 26.6%, p=0.123). Conclusion: The culprit lesions of Off-hour STEMI may more vulnerable compared to STEMI occuring during the working hours.
Extravirgin Olive Oil Consumption Reduces Risk of Atrial Fibrillation
Authors: Miguel Á. Martínez-González, Estefanía Toledo, Fernando Arós, Miquel Fiol, Dolores Corella, Jordi Salas-Salvadó, Emilio Ros, Maria I. Covas, Joaquín Fernández-Crehuet, José Lapetra, Miguel A. Muñoz, Monserrat Fitó, Luis Serra-Majem, Xavier Pintó, Rosa M. Lamuela-Raventós, Jose V. Sorlí, Nancy Babio, Pilar Buil-Cosiales, Valentina Ruiz-Gutierrez, Ramón Estruch, Alvaro Alonso
Journal: Circulation (2014)

Background— The PREDIMED (Prevención con Dieta Mediterránea) primary prevention trial showed that a Mediterranean diet enriched with either extravirgin olive oil or mixed nuts reduces the incidence of stroke, myocardial infarction, and cardiovascular mortality. We assessed the effect of these diets on the incidence of atrial fibrillation in the PREDIMED trial. Methods and Results— Participants were randomly assigned to 1 of 3 diets: Mediterranean diet supplemented with extravirgin olive oil, Mediterranean diet supplemented with mixed nuts, or advice to follow a low-fat diet (control group). Some departures from individual randomization occurred in a subset of the trial because members of the same household and small clinics in one of the 11 recruiting centers were allocated by clusters instead of individually. Incident atrial fibrillation was adjudicated during follow-up by an events committee blinded to dietary group allocation. Among 6705 participants without prevalent atrial fibrillation at randomization, we observed 72 new cases of atrial fibrillation in the Mediterranean diet with extravirgin olive oil group, 92 in the Mediterranean diet with mixed nuts group, and 89 in the control group after median follow-up of 4.7 years. The Mediterranean diet with extravirgin olive oil significantly reduced the risk of atrial fibrillation (hazard ratio, 0.62; 95% confidence interval, 0.45–0.86 compared with the control group) after adjusting for propensity scores and using robust variance estimators to account for the intra-cluster correlations. No effect was found for the Mediterranean diet with nuts (hazard ratio, 0.86; 95% confidence interval, 0.63–1.16). In secondary analyses done after excluding all participants randomized in clusters, the results did not materially change. Conclusions— In the absence of proven interventions for the primary prevention of atrial fibrillation, this post hoc analysis of the PREDIMED trial suggests that a lower incidence of atrial fibrillation was found after an intervention with extravirgin olive oil in the context of a Mediterranean dietary pattern. Clinical Trial Registration— URL: http://www.controlled-trials.com . Unique identifier: ISRCTN35739639.
Observations on the Surface Cells of the Mouse Omentum as Studied With the Phase-Contrast and Electron Microscopes
Authors: M D FELIX
Journal: JNCI Journal of the National Cancer Institute (1961)

The conformation and fine structure of the cells covering the surface of the normal, or control, omentum are described. Some of the observations are of particular interest in the light of past controversies concerning the apposition and potentialities of mesothelial cells. Both macrophages and mesothelial cells compose the surface layer of the milky spots. The mesothelial cells, which are contracted, are in the majority, macrophages being interspersed among them. Openings occur between the cells on the milky spots thus exposing the underlying cells or collagen fibers to the surface. No basement membrane appears beneath any of the cells covering the omentum. The surface cells of the netlike areas of the omentum are flattened, tenuous mesothelial cells that appose each other by adjoining or overlapping. The possible significance of the milky spots and their surface modification in relation to the reticuloendothelial system is discussed. Whether the surface macrophages function as sessile phagocytes or migrate in response to stimulation must be determined by experimental studies. Macrophages and mesothelial cells being close neighbors on the omental surface makes this an advantageous region for comparing their reaction to various stimuli.
Asymptomatic Individuals With a Positive Family History for Premature Coronary Artery Disease and Elevated Coronary Calcium Scores Benefit From Statin Treatment
Authors: Ties A. Mulders, Suthesh Sivapalaratnam, Erik S.G. Stroes, John J.P. Kastelein, Alan D. Guerci, Sara-Joan Pinto-Sietsma
Journal: JACC. Cardiovascular imaging (2012)
Tobacco Lobbying Draws Concern From Senators
Authors: Laura Buchholz
Journal: JAMA (2015)

After a New York Times article reported that the US Chamber of Commerce has been engaged in tobacco lobbying abroad (http://nyti.ms/1gk16TC), a group of Democratic senators released a statement imploring the business organization to reconsider its priorities (http://1.usa.gov/1CnccRX).
Is PSA Testing Still Useful?
Authors: Mike Mitka
Journal: JAMA (2004)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Revalidation for doctors
Authors: J. Parboosingh
Journal: BMJ (1998)

The present public demand for periodic revalidation of doctors is inevitable. The tradition of graduating from a training programme and obtaining a licence for life seems naive in this era when the quality of care we provide is so dependent on our efforts to keep up to date. It is considerations such as these that have prompted Britain's General Medical Council to open discussions with the Academy of Royal Colleges and other professional bodies on the concept of regular revalidation of doctors on the specialist and generalist registers.

The objectives of periodic revalidation are to encourage doctors to respect changes in societal values and integrate into their practices innovations that are shown to enhance patient care and also to give recognition to doctors who meet national standards of competence and performance. Delays in establishing such systems are understandable. In many countries regional shortages of specialists and primary care doctors will inevitably complicate the implementation of mandatory revalidation of doctors working in regions of greatest need. More importantly, the standards of competence and performance incorporated into a revalidation process must be sufficiently rigorous to distinguish reliably between those who should …
Endothelin signaling in osteoblastic metastases: molecular mechanisms and biomarkers
Authors: Charles Van Sant, Gang Wang, Mark Anderson, Rick Lesniewski, Dimitri Semizarov
Journal: Clinical Cancer Research (2006)

A86  Osteoblastic metastases are common in advanced prostate cancer and some cases of breast cancer. It has been shown that uncontrolled bone formation at the site of metastasis is caused by a number of growth factors, in particular endothelin-1 (ET-1). Secretion of ET-1 by prostate cancer cells is a major factor in formation of osteoblastic metastases. A highly specific antagonist of the ETa receptor, ABT-627, has been developed by Abbott for the treatment of metastatic prostate cancer.To elucidate the molecular mechanism of ET1-mediated bone formation, we established an in vitro osteoblast model system that was responsive to ET-1 treatment. A genomic screen of the ET-1-treated osteoblasts was followed by pathway analysis of the resulting gene expression signature. This analysis revealed three major themes: osteoblastic differentiation, survival, and invasion. We also observed coordinated induction of genes that constitute the calcineurin/NFAT pathway. Follow-up experiments demonstrated that ET-1 induces calcineurin activity in osteoblasts, followed by nuclear translocation of NFATc1 and NFAT-mediated transcription.An independent set of experiments demonstrated that ET-1 protects osteoblasts from apoptosis induced by several known apoptosis inducers with different mechanisms of action (such as actinomycin D and TNF-alpha). This finding, combined with the previous observations of only weak mitogenic effects of ET-1 on osteoblasts, suggests that suppression of apoptosis is the main mechanism whereby ET-1 promotes osteoblastic metastasis in prostate cancer.The ET-1 signature in osteoblasts contained several genes coding for secreted proteins previously implicated in invasion and metastasis. Their secretion was confirmed by ELISA. These proteins are currently being explored as biomarkers for osteoblastic metastasis and PD biomarkers for ABT-627.Our results suggest that ET-1 stimulates bone growth at the metastatic sites by activating the calcineurin/NFAT pathway in osteoblasts and suppressing apoptosis in osteoblasts. These findings provide the foundation for further drug discovery efforts in metastatic prostate cancer. Additionally, we identified several candidate biomarkers that can be used to monitor the progression of osteoblastic metastases and the efficacy of antimetastatic therapies.
p53 inactivation upregulates p73 expression through E2F mediated transcriptional regulation
Authors: Chaitali Tophkhane, Shihe Yang, Toshiyuki Sakai, Wanguo Liu, XiaoHe Yang
Journal: Cancer Research (2008)

AACR Annual Meeting-- Apr 12-16, 2008; San Diego, CA

2784 

p73 is a structural and functional homologue of tumor suppressor p53. Overexpression of wild type p73 is frequently detected in breast and other cancers. How this putative tumor suppressor is overexpressed in cancer cells is not clear. Although it is speculated that activation of p73 may compensate p53 functions in cells with p53 mutation/inactivation, molecular regulation of p73 by p53 remains controversial. To investigate the effect of p53 inactivation on p73 expression, we first established a stable cell line, MCF-7/p53siRNA, in which wild type p53 in MCF-7 cells was knocked down using p53-specific siRNA. We found that both protein and mRNA levels of TAp73 were increased in MCF-7/p53siRNA cells, as compared to MCF-7/control. This suggests that p53 inactivation may upregulate p73. Consistently, upregulation of p73 was also detected in MCF-7 cells transfected with dominant negative mutant p53 (p53mt135) or HPV E6, which induces functional inactivation of p53. To study the mechanism of p53 knockdown mediated upregulation of p73 regulation, we examined the activation of p73 promoter using reporter gene assay and studied p73 protein turnover rate with cycloheximide (CHX) blocking. The results indicate that p53 knockdown results in the activation of TAp73 promoter (-2713 to +77). In contrast, p73 protein turnover rates between the two sublines were not significantly affected, suggesting that p53 knockdown mediated upregulation of p73 is primarily regulated at the transcription level. Although p53 has a putative binding site in the TAp73 promoter, deletion of this binding site did not affect p53 knockdown mediated activation of TAp73 promoter. Since E2F-1 is a major transcription factor that regulates p73 transcription, we examined whether p53 inactivation affects E2F-1 mediated transcription of p73. We found that p53 knockdown enhanced the E2F-1 dependent p73 transcription, and mutations in E2F-1 binding sites in the p73 promoter abrogated p53 knockdown mediated activation of p73 promoter. Taken together, our results demonstrate that p53 knockdown/inactivation may upregulate TAp73 expression through E2F mediated transcriptional regulation. Our findings highlight the interactions between p53 and TAp73, which may play an important role in the regulation of p53 independent apoptosis and tumor suppression.