tbuckley/cabot-search huggingface dataset:
Abstract 3317: Single-cell invasion and chemoresistance of slowly proliferating brain-tumor stem cells
Authors: Florian A. Siebzehnrubl, Daniel J. Silver, Loic P. Deleyrolle, Oleg Suslov, Bugra Tugertimur, Antony T. Yachnis, Simone Brabletz, Thomas Brabletz, Brent A. Reynolds, Dennis A. Steindler
Journal: Cancer Research (2011)

Abstract Despite intense efforts in basic research and clinical medicine, glioblastoma (GBM) remains one of the most lethal types of cancer. In particular, tumor recurrence after surgical resection, aggressive chemotherapy, and targeted radiation remains an insurmountable obstacle. Recurrence may be attributed to residual cancer stem cells that re-initiate tumor growth after primary clinical intervention. Here, we provide new evidence for a subpopulation of relatively quiescent and chemoresistant cancer stem cells that invade deeply into the parenchyma. We have identified a critical transcription factor that is upregulated in these glioma stem cells, which regulates epithelial-mesenchymal transition (EMT) in other tumors. Knockdown of this transcription factor results in an increased sensitivity to chemotherapeutic agents and reduced tumor cell invasion. We hypothesize that single cell invasion of malignant gliomas is regulated by similar molecular pathways as EMT and metastasis in solid tissue tumors. These pathways allow slowly proliferating glioma stem cells to leave the site of the primary tumor, invade deeply into the surrounding parenchyma and, by virtue of their resistance to chemotherapeutic agents, evade all types of classical brain tumor therapy. This offers a potential novel model for GBM recurrence, and a potential new therapeutic target. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 102nd Annual Meeting of the American Association for Cancer Research; 2011 Apr 2-6; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2011;71(8 Suppl):Abstract nr 3317. doi:10.1158/1538-7445.AM2011-3317
TCT-719 Effects of ranolazine in patients with acute coronary syndrome and stable angina according to whether they undergo percutaneous coronary intervention: Observations from the MERLIN-TIMI 36 Trial
Authors: Benjamin Scirica, Sabina Murphy, Ewa Karwatowska-Prokopczuk, Gennyne Walker, Luiz Belardinelli, Ori Ben-Yehuda, David Morrow
Journal: Journal of the American College of Cardiology (2012)
Selective Biliary Cannulation Using Pancreatic Guide-Wire Placement: Reply to Dr. Saad
Authors: S. Maeda, H. Hayashi, O. Hosokawa
Journal: Endoscopy (2004)

We are grateful to Dr. Saad [1] for his interest in our article [2]. We agree that it is important to be cautious during bile duct cannulation, as was also mentioned in the editorial by Dr. Devière [3]. However, as Dr. Saad also points out, there are certainly clinical situations that cannot be managed with the conventional method without great difficulty and danger for patients. Our main reason for conducting the study was that prior insertion of a pancreatic guide wire might be a sensible option in these difficult cases.
The Dynamics of Ventricular Contraction and Relaxation in Patients With Mitral Stenosis as Studied by the Kinetocardiogram and Ballistocardiogram
Authors: E. E. EDDLEMAN, ROBERT H. YOE, WILLIAM T. TUCKER, JOHN L. KNOWLES, KATHRYN WILLIS
Journal: Circulation (1955)

Kinetocardiograms (precordial movements) and ballistocardiograms were studied in patients with "pure" mitral stenosis. The findings were correlated with catheterization data and clinical findings. Certain characteristics of the kinetocardiograms were presented as well as hypothesis for the movements of the heart and dynamics of ventricular contraction and relaxation in patients with mitral stenosis.
Perfluorochemicals and Human Semen Quality: The LIFE Study
Authors: Germaine M. Buck Louis, Zhen Chen, Enrique F. Schisterman, Sungduk Kim, Anne M. Sweeney, Rajeshwari Sundaram, Courtney D. Lynch, Robert E. Gore-Langton, Dana Boyd Barr
Journal: Environmental Health Perspectives (2014)

The relation between persistent environmental chemicals and semen quality is evolving, although limited data exist for men recruited from general populations.We examined the relation between perfluorinated chemicals (PFCs) and semen quality among 501 male partners of couples planning pregnancy.Using population-based sampling strategies, we recruited 501 couples discontinuing contraception from two U.S. geographic regions from 2005 through 2009. Baseline interviews and anthropometric assessments were conducted, followed by blood collection for the quantification of seven serum PFCs (perfluorosulfonates, perfluorocarboxylates, and perfluorosulfonamides) using tandem mass spectrometry. Men collected a baseline semen sample and another approximately 1 month later. Semen samples were shipped with freezer packs, and analyses were performed on the day after collection. We used linear regression to estimate the difference in each semen parameter associated with a one unit increase in the natural log-transformed PFC concentration after adjusting for confounders and modeling repeated semen samples. Sensitivity analyses included optimal Box-Cox transformation of semen quality end points.Six PFCs [2-(N-methyl-perfluorooctane sulfonamido) acetate (Me-PFOSA-AcOH), perfluorodecanoate (PFDeA), perfluorononanoate (PFNA), perfluorooctane sulfonamide (PFOSA), perfluorooctane sulfonate (PFOS), and perfluorooctanoic acid (PFOA)] were associated with 17 semen quality end points before Box-Cox transformation. PFOSA was associated with smaller sperm head area and perimeter, a lower percentage of DNA stainability, and a higher percentage of bicephalic and immature sperm. PFDeA, PFNA, PFOA, and PFOS were associated with a lower percentage of sperm with coiled tails.Select PFCs were associated with certain semen end points, with the most significant associations observed for PFOSA but with results in varying directions.
Successful Treatment of Hepatic Coma by Exchange Transfusions
Authors: Maxewll L. Gelfand
Journal: JAMA (1967)

Hepatic coma developed in a 25-year-old Negro woman with serum hepatitis 24 days after admission. The patient deteriorated and became moribund despite therapy with g'ucose administered intravenously, neomycin sulphate, large doses of steriods, and careful attention to electeolyte balance. Four days later exchange transfusions were begun. She received 5 pt of properly matched blood treated with heparin sodium the first day; 10 pt the second day, and 8 units the third day. Twelve hours after the last exchange, the patient dramatically awoke from her coma and subsequently recovered completely. We believe that exchange transfusions played a significant role in the result obtained and recommend its early use in hepatic coma resulting from fulminating hepatitis.
Review: Angiotensin-receptor blockers increase risk for cancer but not cancer-related death
Authors: John P. Vavalle, L. Kristin Newby
Journal: Annals of Internal Medicine (2010)

Source Citation Sipahi I, Debanne SM, Rowland DY, Simon DI, Fang JC. Angiotensin-receptor blockade and risk of cancer: meta-analysis of randomised controlled trials. Lancet Oncol. 2010;11:627-36. 20542468
Case of Toxoplasma Polymyositis
Authors: K. Chandar, H. J. Mair, N. S. Mair
Journal: BMJ (1968)

BitfsH days for one to two weeks; they noted no toxicity.Sutton (1938) also remarked on its lack of toxicity when used as a local application.However, Slotkowski (1957) reported the case of a child who developed ulceration of his oral mucosa as a result of excessive crystal violet treatment.He remarked on the need to be aware of this possible complication of treatment and suggested that it might previously have been mistaken for a result of the candidial infection.At other sites crystal violet is well recognized as a potential irritant.When vaginal candidiasis is treated with local applica- tions of crystal violet some patients have to discontinue treatment because of its irritant effects (Jennison and Llywelyn-Jones, 1957).If the dye is in accidental contact with the conjunctival epithelium it will cause oedema, hyperaemia, and necrosis of the epithelium within a few hours (Hosford and Smith, 1952).When taken orally as a vermifuge, crystal violet may cause diarrhoea, nausea, and vomiting, suggesting a local effect on the gastrointestinal mucosa (Beckman, 1961 ; Martin- dale, 1967).It might therefore be expected that similar reactions could occur when crystal violet is applied to the oral mucosa.It seems likely that many oral mucosal reactions to crystal violet have gone unrecognized, and it is clear that if crystal violet is used it should be limited to a maximum course of three days with twice-daily applications.As nystatin suspension now provides a satisfactory method of treating oral candidiasis, there would seem to be a substantial case for the abandonment of local crystal violet applications to the oral mucosa.It might be that many sore mouths associated with thrush would dis appear along with the crystal violet.
Mutations of Chk2 in primary hematopoietic neoplasms
Authors: Akira Hangaishi, Seishi Ogawa, Ying Qiao, Lili Wang, Noriko Hosoya, Koichiro Yuji, Yoichi Imai, Kengo Takeuchi, Shuichi Miyawaki, Hisamaru Hirai
Journal: Blood (2002)
The Case of the Triangular Foreign Body
Authors: Daniel D. Von Hoff
Journal: JAMA (1978)

To the Editor.—  At times foreign bodies present diagnostic dilemmas. The following is a case of an unusual but distinctly shaped foreign body in the esophagus.  Report of a Case.—  A 54-year-old nurse with a five-year history of ovarian cancer had been treated with radiotherapy and later with HEXACAF (a combination of methenamine, cyclophosphamide, methotrexate, and fluorouracil). She originally responded to HEXACAF, but because of progressive disease, her therapy was switched to cis -diamminedichloroplatinum II on an every three-week schedule. During her admission on July 6, 1977, she had a routine chest roentgenogram that demonstrated what appeared to be a foreign body in the midesophageal region (Fig 1). The object was radiodense, with a rather distinctive triangular shape. The patient denied any history of dysphagia or dyspnea and in the last 12 hours had swallowed only one tablet of Pepto-Bismol (subsalicylate bismuth, phenyl salicylate, and phenolsulfonate zinc), which she felt
Vancomycin-resistant enterococci bacteremia: Risk factors for mortality and influence of antimicrobial therapy on clinical outcome
Authors: Sang Hoon Han, Bum Sik Chin, Han Sung Lee, Su Jin Jeong, Hee Kyoung Choi, Chang Oh Kim, Dongeun Yong, Jun Yong Choi, Young Goo Song, Kyungwon Lee, June Myung Kim
Journal: Journal of Infection (2009)
Primary managed care in Europe
Authors: C. Ham
Journal: BMJ (1997)

Primary care is at the heart of the agenda for health policy in several countries. A recent management report from the Financial Times brings together information on the organisation and financing of primary care in five European countries and summarises government initiatives to strengthen primary care.1 As the report shows, primary care plays a bigger part in the health systems of Britain, Spain, and Italy than in France and Germany. Furthermore, there are many different approaches to organising primary care services and paying doctors. Government initiatives to move provision of health care to primary care include emphasising the gatekeeper role of general practitioners, developing the contribution of pharmacists as providers of primary health care, and using advances in healthcare technology to relocate services from hospitals to communities.

Reflecting its origins and the focus of the publishers, the report concentrates particularly on the implications of these developments for the drug industry. These include the switch of products from prescription only medicines to over the …
Treatment of Angioimmunoblastic Lymphadenopathy (AILD)-Type T-Cell Lymphoma Using Prednisone with or without the COPBLAM/IMVP-16 Regimen
Authors: Wolfgang Siegert, Alexander Agthe, Henrik Griesser, Rainer Schwerdtfeger, Günter Brittinger, Marianne Engelhard, Rolf Kuse, Markus Tiemann, Karl Lennert, Dieter Huhn
Journal: Annals of Internal Medicine (1992)

▪ Objective: To describe the clinical course of patients with angioimmunoblastic lymphadenopathy (AILD)-type lymphoma with a sequential treatment with prednisone and COPBLAM/IMVP-16. ▪ Design: A multicenter, prospective, nonrandomized trial. ▪ Setting: University medical centers and community hospitals. ▪ Patients: Sixty-seven patients were registered, 28 were excluded, and 39 patients were evaluable for response (median age, 59 years; range, 25 to 82 years) (stages I and II, 10%; stages III and IV, 90%; B symptoms, 74%). ▪ Measurements: Response, survival, and relapse. ▪ Intervention: Patients initially received prednisone and no further treatment if a complete remission was achieved. Relapsing or refractory patients were treated with COPBLAM/IMVP-16. Patients with life-threatening tumor progression or extension received COPBLAM/IMVP-16 initially. Treatments were chosen in accordance with tumor extension and response to prednisone. Treatment modalities were not compared. ▪ Results: Twenty-eight patients received primary prednisone, 18 received secondary prednisone, and 11 received primary chemotherapy. The complete response rates (with 95% Cls) were 29% (Cl, 12% to 46%), 56% (Cl, 33% to 79%), and 64% (Cl, 36% to 92%), respectively. The median observation time of surviving patients was 28 months (range, 7 to 53). The median overall survival time was 15 months. The probabilities (with 95% Cls) of overall survival, event-free survival, and relapse at 36 months were 40.5% (Cl, 24% to 56%), 32.3% (Cl, 17% to 47%), and 34.6% (Cl, 14% to 56%), respectively. At the time of evaluation, 22 of 39 patients had died, 7 of noninfectious complications and 14 of infections. ▪ Conclusions: Prednisone with or without COPBLAM/IMVP-16 treatment in AILD-type lymphoma leads to complete remissions in about half of the patients and in long-term, disease-free survival for one third.
GENERAL MEDICINE A SPECIALTY IN ITSELF; ITS RELATION TO THE RECOGNIZED SPECIALTIES, PARTICULARLY TO BACTERIOLOGY.
Authors: GEORGE BYRD HARRISON
Journal: JAMA (1897)

I wish to urge upon you, as forcibly as I can, that the time has come when we should claim with all our energy that the department of medicine in which we are engaged (the noblest of all the divisions of the science, because the most comprehensive, and calling into play the intellectual faculties as none other can possibly do), is, and of right should be, a<i>specialty</i>in itself, claiming not only<i>recognition</i>from the "manipulative" (or otherwise limited), recognized specialties, but occupying toward them the position of a parent to children—a fostering care which they can not do without, unless they are content to be relegated to the domain of sciolism and quackery. These are strong expressions, but not too emphatic for the occasion. A brilliant medical man, of admirable attainment in the theory of medicine, of thorough hospital training and very considerable experience in private practice, told
Antitumor Activity of miR-1280 in Melanoma by Regulation of Src
Authors: Vera Sun, Wen B Zhou, Mehdi Nosrati, Shahana Majid, Suresh Thummala, David de Semir, Vladimir Bezrookove, Sebastien de Feraudy, Liane Chun, Dirk Schadendorf, Robert Debs, Mohammed Kashani-Sabet, Altaf A Dar
Journal: Molecular Therapy (2014)

MicroRNAs (miRNAs) play a key role in cancer progression by coordinately repressing target genes involved in cell proliferation, migration, and invasion. miRNAs regulate gene expression by repressing translation or directing sequence-specific degradation of complementary mRNA. Here, we report that expression of miR-1280 is significantly suppressed in human melanoma specimens when compared with nevi, and in human melanoma cell lines when compared with cultured normal human melanocytes. The proto-oncogene Src was identified as a target of miR-1280 action. Levels of Src expression were significantly higher in melanoma samples and cell lines than in nevi and normal melanocytes. miR-1280 overexpression significantly suppressed the luciferase activity of reporter plasmids containing the full-length 3′ untranslated region of Src. miR-1280-mediated suppression of Src led to substantial decreases in melanoma cell proliferation, cell cycle progression, invasion, as well as induced melanoma cell apoptosis. The effects of miR-1280 overexpression on melanoma cell proliferation and growth were reversed by Src overexpression. Intratumoral delivery of miR-1280 significantly suppressed melanoma cell growth in vivo. Our results demonstrate a novel role for miR-1280 as a tumor suppressor in melanoma, identify the Src signaling pathway as a target of miR-1280 action, and suggest a potential therapeutic role for miR-1280 in melanoma. MicroRNAs (miRNAs) play a key role in cancer progression by coordinately repressing target genes involved in cell proliferation, migration, and invasion. miRNAs regulate gene expression by repressing translation or directing sequence-specific degradation of complementary mRNA. Here, we report that expression of miR-1280 is significantly suppressed in human melanoma specimens when compared with nevi, and in human melanoma cell lines when compared with cultured normal human melanocytes. The proto-oncogene Src was identified as a target of miR-1280 action. Levels of Src expression were significantly higher in melanoma samples and cell lines than in nevi and normal melanocytes. miR-1280 overexpression significantly suppressed the luciferase activity of reporter plasmids containing the full-length 3′ untranslated region of Src. miR-1280-mediated suppression of Src led to substantial decreases in melanoma cell proliferation, cell cycle progression, invasion, as well as induced melanoma cell apoptosis. The effects of miR-1280 overexpression on melanoma cell proliferation and growth were reversed by Src overexpression. Intratumoral delivery of miR-1280 significantly suppressed melanoma cell growth in vivo. Our results demonstrate a novel role for miR-1280 as a tumor suppressor in melanoma, identify the Src signaling pathway as a target of miR-1280 action, and suggest a potential therapeutic role for miR-1280 in melanoma.
Coronary flow reserve immediately after reperfusion predicts infarct size in patients with acute myocardial infarction without diabetes mellitus
Authors: Takefumi Takahashi, Yoshikazu Hiasa, Takeshi Tomokane, Koji Yamaguchi, Riyo Ogura, Yoshikazu Ohara, Kanji Kasunoki, Kenichiro Yuba, Tatsuro Ogata, Shinobu Hosokawa, Koichi Kishi, Ryuji Ohtani
Journal: Journal of the American College of Cardiology (2003)
Ethics in Obstetrics and Gynaecology
Authors: G. M Stirrat
Journal: BMJ (1995)

Ed Susan Bewley, R Humphry Ward RCOG Press, pounds sterling35, pp 364 ISBN 0 902331 69 8

The front line role of obstetricians and gynaecologists in dealing with the major ethical flashpoints in medicine makes it vital that the ethical basis for good practice be given a high priority by the Royal College of Obstetricians and Gynaecologists, publishers of Ethics in Obstetrics and Gynaecology.

Gordon Dunstan outlines what is needed for consistent translation of moral theory into practical judgments. At the clinical level (which must include the conduct of research) he asserts that “it concerns judgement, choices and decisions taken within certain governing relationships.” …
Automated Measurement of Human Basophil Degranulation
Authors: F. Leynadier, H. Luce, A. Abrego, J. Dry
Journal: Allergy (1981)

Basophils disappear after challenge with specific antigen. A human basophil degranulation test has been carried out on a slide using an enriched cell suspension. On each slide, the same volume of cell suspension was deposited in wells with antigen diluted in buffer or with buffer only (control). The basophil count was made on an equal number of randomly distributed microscopic fields either by eye (optical) or by image analyser (automatic). In 33 subjects, the correlation coefficient between the numbers of non-degranulated basophils counted by eye and by image-analyser on control wells was found to be r-0.91, p less than 10-8. In 12 patients (6 with hydatidosis and 6 with schistosomiasis), the percentage of degranulation with three antigen dilutions was measured. The correlation between the results obtained by eye and by image-analyser reached 0.76 (p less than 10-7). The authors now use the automated measurement of human basophil degranulation routinely.
Spectre of SARS still looms
Authors: Kathryn Senior
Journal: The Lancet Infectious Diseases (2004)

There have been no severe acute respiratory syndrome (SARS) cases since the end of the northern summer but worries are mounting of a recurrence in the winter season. "All the evidence points to a wild-animal source for the SARS coronavirus, but this source remains to be found. If the same set of circumstances occur this year in which the human population in southern China and north Vietnam is exposed again, we could certainly see more cases", comments Meirion Evans (University of Wales College of Medicine, Cardiff, UK), a member of the SARS Expert Committee.
Haemodialysis and forced diuresis for tricyclic antidepressant poisoning.
Authors: R R Bailey, J R Sharman, J O'Rourke, A L Buttimore
Journal: BMJ (1974)

Alpha-fetoprotein and Rh Alloimmunization SIR,--An increase in alpha-fetoprotein (AFP) has been reported in amniotic fluid from fetuses with fetal distress, including fetal distress of Rh alloimmunue origin.' 2We have assayed by radioimmunoassay' specimens of amniotic fluid from a number of Rh alloimmune pregnant women and report the results of the assay of: (1) 72 specimens from 46 women with 27-42-weekold normal or sulbnormal fetuses and (2) 27 specimens from 12 women with 27-38week-old fetuses with severe haemolytic anaemia which, 3-14 da,ys after amniocen- tesis, either died or required intrauterine blood transfusion or were born with levels of haemoglobin below 10 g/ 100 ml.Resultsof AFP determinations are shown in the figure.Mean gestational age ( in weeks)10C O-27.5 29.5 31.5 33.5 35.5 37.
Atypical hand, foot, and mouth disease associated with coxsackievirus A6 infection, Edinburgh, United Kingdom, January to February 2014
Authors: C Sinclair, E Gaunt, P Simmonds, D Broomfield, N Nwafor, L Wellington, K Templeton, L Willocks, O Schofield, H Harvala
Journal: Eurosurveillance (2014)

In January to February 2014, 16 hand, foot and mouth disease (HFMD) cases were identified in Edinburgh, United Kingdom. All presented with atypical features, with most (n=13) resembling eczema herpeticum or chickenpox. Coxsackievirus A6 (CV-A6) was identified in all the typed cases (n=11). As atypical forms of HFMD associated with CV-A6 are likely to emerge throughout Europe, clinicians should be alert to unusual clinical presentations of HFMD and virologists aware of effective diagnostic testing and enterovirus typing methods.
EEG Evaluation of Lidocaine Convulsions
Authors: Richard S. Crampton
Journal: JAMA (1968)

<h3>To the Editor:—</h3> With regard to convulsions and respiratory arrest during intravenously administered lidocaine hydrochloride treatment of ventricular tachycardia, I am indebted to Dr. J.T.M. Bamford, of Cooperstown, NY, for drawing attention to an electroencephalographic evaluation of convulsions and respiratory arrest induced by lidocaine<sup>1</sup>omitted from my report (<b>204</b>: 201,1968). In this study, six normal volunteers were given 1.5 to 3 mg/kg/min of lidocaine intravenously for two to six minutes until convulsions appeared. Three exhibited respiratory arrest lasting 260, 310, and 295 seconds, respectively. The convulsions lasted 105 to 125 seconds, and electroencephalographic records revealed epileptic spikes during all seizures. The total convulsant dose ranged from 6 to 9 mg/kg. During the infusion of lidocaine, a transient rise of respiratory rate was followed by decreased excursion of the thorax. Apnea during the convulsion persisted 10 to 15 seconds after the fit with the chest fixed in the expiratory phase