Evaluation of Grid Pattern Photocoagulation for Macular Edema in Central Vein Occlusion
Authors: John G. Clarkson, Elaine Chuang, Donald Gass, Maria Pedroso, Tony Cubillas, Erlinda S. Duria, Ditte J. Hess, Isabel Rams, Marguerite Ball, Alex Gutierrez, Nayla Muniz, June Thompson, Michele Pall, Charles J. Pappas, Daniel Finkelstein, Arnall Patz, Dolores Rytel, Judy Belt, Dennis Cain, Terri Cain, David Emmert, Terry George, Mark Herring, Pete Sotirakos, David H. Orth, Timothy P. Flood, Kirk H. Packo, Toni Larsen, Nancy Perez, Doug Bryant, Don Doherty, Jay Fitzgerald, Martha Gordon, Cynthia Holod, Kathy Kwiatkowski, Celeste MacLeod, Chris Morrison, Charlotte Westcott, Michael L. Klein, David Wilson, Richard G. Weleber, Susan Nolte, Nancy Hurlburt, Mark Evans, Patrick Wallace, Peter Steinkamp, Debora Funkner, Cathy Gordon, Clement Trempe, Alex Jalkh, John Weiter, Sherry Anderson, Dennis Donovan, Tom O'Day, Gerald Friedman, Rodney Immerman, Gabriel Coscas, Gisele Soubrane, Rose Marie Haran, Christophe Debibie, Jean Gizelsky, Ingolf H.L. Wallow, Guillermo de Venecia, George Bresnick, Sandra Larson, Sandy Fuller, Bob Harrison, Gene Knutson, Michael Neider, Greg Weber, Ruth Bahr, Bonnie Grosnick, Robert Lazorik, Helen Lyngaas, Diane Quackenboss, Guy Somers, Froncie A. Gutman, Sanford Myers, Tina Kiss, Deborah Ross, Pamela Vargo, Janet Edgarton, Sue Hanson, Janet Nader, Nancy Tomsak, Lawrence J. Singerman, Hernando Zegarra, Susan Lichterman, Adrienne Fowler Kramer, Sheila Smith-Brewer, Pam Brown Rowe, Geraldine Daley, Anne Pinter, Kathy Coreno, Lori Cooper, Marty Delisio, Donna Cross, Wendy Lord, Argye Hillis, Mark W. Riggs, Cheryl KasbergPreece, M. Hasan Rajab, Krista Carlson Giniewicz, Kevin Gilmore, Carol Zimmerman, John G. Clarkson, Mary Lou Lewis, Elaine Chuang, Maria Cristina Wells, Julie Lord Forbes, Kathleen C. Fetzer, Heather McNish, George H. Bresnick, Sandy Fuller, Lissa McNulty, Jim Baliker, Linda Alanen, Laura Gentry, Richard L. Mowery, Donald F. Everett, John G. Clarkson, George H. Bresnick, Gabriel Coscas, Daniel Finkelstein, Froncie A. Gutman, Argye Hillis, Michael L. Klein, Richard L. Mowery, Donald F. Everett, David H. Orth, Lawrence J. Singerman, Clement Trempe, Robert J. Hardy, Gary Abrams, Robert N. Frank, Maureen G. Maguire, Abner V. McCall, John G. Clarkson, Donald F. Everett, Argye Hillis
Journal: Ophthalmology (1995)

<b>Purpose:</b> To evaluate the efficacy of macular grid photocoagulation in preserving or improving central visual acuity in eyes with macular edema due to central vein occlusion (CVO) and best-corrected visual acuity of 20/50 or poorer. <b>Methods:</b> Patients with angiographically documented macular edema due to CVO were entered into a multicenter randomized controlled clinical trial supported by the National Eye Institute. Eligibility was determined based on both clinical examination findings and photographic documentation evaluated at a photograph reading center. Eyes were assigned randomly to macular grid photocoagulation (77 eyes) or no treatment (78 eyes). Patients were followed every 4 months for 3 years or until the end of the study. The outcome measure was visual acuity. <b>Results:</b> The study population consisted of 155 eyes in 155 patients. There was no difference between treated and untreated eyes in visual acuity at any point during the follow-up period. Initial median visual acuity was 20/160 in treated eyes and 20/ 125 in control eyes. Final median visual acuity was 20/200 in treated eyes and 20/160 in control eyes. However, treatment clearly reduced angiographic evidence of macular edema. <b>Conclusion:</b> The results of this study do not support a recommendation for macular grid photocoagulation for the population meeting the Central Vein Occlusion Study macular edema group eligibility criteria.