tbuckley/cabot-search huggingface dataset:
Lifelong severe verrucosis associated with human papillomavirus type 2: report of a case with a 38-year follow-up
Authors: None Requena, None Sarasa, None Terai, None Sata, None Matsukura
Journal: British Journal of Dermatology (1998)

We describe a 67-year-old woman with disseminated warts which she had had for more than 38 years. The lesions consisted of common and plane warts, wart-like plaques and red-brownish macules similar to those in pityriasis versicolor. Furthermore, during follow-up, several solar keratoses, plaques of Bowen's disease and invasive squamous cell carcinomas were excised. The patient also had T-cell immunodeficiency of unknown aetiology. Histopathology demonstrated that all the warts showed the cytopathological features of common warts, but not those of the warts in epidermodysplasia verruciformis (EV). We investigated the presence of human papillomavirus (HPV) DNA in the warts by blot hybridization and molecular cloning and found that the lesions harboured HPV 2, but not EV–HPVs or other HPVs. In addition, the histopathological distribution of the viral DNA was confirmed in paraffin sections of warts from the patient at different ages by in situ hybridization. However, these investigations yielded negative results in specimens of Bowen's disease and invasive squamous cell carcinoma. These results demonstrated that the patient had been infected with HPV 2 from childhood, but the negative results for detection of DNA of HPV 2 in carcinomas from the patient do not support an oncogenic potential for HPV 2. In conclusion, HPV 2, an aetiological agent of common warts in the general population, may induce a lifelong severe verrucosis in some immunosuppressed patients.
Using injury data for violence prevention
Authors: J. P Shepherd
Journal: BMJ (2000)

The UK government has indicated that its plans to tackle community violence will be based not just on information about offences but also on injury data derived from emergency departments.1 This stems from evidence both nationally and internationally of the substantial extent to which violence that results in injury is not investigated by the police. 2 3

In the 11 industrialised countries which took part in the 1996 international victimisation survey the median reporting rate of violent offences was 39%, ranging from 18% to 51%.4 In the UK only about 25% to 50% of offences which lead to treatment in emergency departments appear in police records, 5 6 a proportion consistent with the findings of biennial British crime surveys, which allow comparison of householders' accounts of crime with police records. One study in the US found that only 54% of assaults treated in an emergency department were documented by the police.7 A study of emergency department attendees carried out in Bristol showed that assaults on men and assaults occurring in bars, nightclubs, and public streets were less likely to …
Characterization of extensively drug-resistant mycobacterium tuberculosis in Siberia
Authors: Maya Dymova, Olga Alkhovik, Andrey Cherednichenko, Tatyana Petrenko, Maxim Filipenko
Journal: European Respiratory Journal (2013)

The emergence of extensively drug-resistant TB (XDR-TB) is widely considered a serious threat to global TB control. Although molecular characterization of drug resistance-associated mutations in multidrug-resistant isolates in Siberia has been made, mutations in XDR isolates and their genotypes have not been reported previously. In this study, we identified and characterized 29 extensively drug resistance Mycobacterium tuberculosis isolates from clinical isolates in Siberia. The most prevalent mutations involved in isoniazid, rifampicin, ofloxacin, streptomycin resistance were Ser315Thr in katG gene, Ser531Leu in rpoB gene, Asp94Gly in gyrA gene, Lys43Arg in rpsL gene, Glu92Asp in gidB gene respectively. VNTR – typing and deligotyping revealed that 93% belonged to Beijing family, 11 of them belonged to highly virulent type M11 (39.2 %). We also found two isolates belonged to LAM family, the second most common family in Russia, as well as Beijing-associated to multi drug resistance. Due to the epidemiological significance of both families it can be recommended deligotyping as a method of use for prescreening, and then VNTR-typing, for a more detailed differentiation of isolates M. tuberculosis. Our result highlights the need to reinforce the TB policy in Siberia with regard to control and detection strategies.
Principles and Methods for the Preparation of Drug Protein Conjugates for Immunological Studies
Authors: Bernard F. Erlanger
Journal: Pharmacological Reviews (1973)

A brief review has been presented of the many procedures applicable for the preparation of hapten-protein conjugates that can be used to elicit antibodies to biologically interesting compounds. This review has been organized in a way to make it easier for the working scientist to recognize and thus utilize methods that would be suitable for his own research problems. Despite the recent upsurge in the application of immunological methods for the investigation of small biological molecules, there are still many more applications possible, and it is hoped that this review will encourage and facilitate some of them.
Abstract 19271: Effect of Transcatheter Aortic Valve Implantation on Neurohumoral Activation and NYHA Functional Class
Authors: Stefan Stortecky, Thomas Pilgrim, Alexander Kadner, Balthasar Eberle, Bernhard Meier, Thierry Carrel, Peter Wenaweser, Stephan Windecker
Journal: Circulation (2010)

Background: Severe aortic valve stenosis often is accompanied by severe symptoms of congestive heart failure (CHF) restricting quality of life in elderly patients. Natriuretic peptides like B-type ...
Scientific Meeting of the Netherlands Society for Dermatology and Venereology, 4 June 1994
Authors: C.A.F.M. BRUIJNZEEL-KOOMEN, F.C. REIJSEN, G.R. DUBOIS, E.G. LANGEVELD-WILDSCHUT, I.J. VRIES, M.M. PANIS, G.C. MUDDE, T. THEPEN
Journal: British Journal of Dermatology (2010)
Prognostic Factors in Nonmetastatic Ewing’s Sarcoma of Bone Treated With Adjuvant Chemotherapy: Analysis of 359 Patients at the Istituto Ortopedico Rizzoli
Authors: Gaetano Bacci, Stefano Ferrari, Franco Bertoni, Simonetta Rimondini, Alessandra Longhi, Patrizia Bacchini, Cristiana Forni, Marco Manfrini, Davide Donati, Piero Picci
Journal: Journal of Clinical Oncology (2000)

PURPOSE: The identification of prognostic factors in patients with nonmetastatic Ewing’s sarcoma could allow the use of risk-adapted therapeutic strategies of treatment. PATIENTS AND METHODS: Data on 359 patients with nonmetastatic Ewing’s sarcoma of bone treated at a single institution between January 1979 and April 1995 were retrospectively considered. The influence of clinical, hematologic, therapeutic, and histologic parameters on event-free survival was assessed. RESULTS: By univariate analysis, the following features were found to be associated with a poor prognosis: male sex (P &lt; .02), age older than 12 years (P &lt; .006), fever (P &lt; .0001), anemia (P &lt; .0025), high serum lactate dehydrogenase (LDH) level (P &lt; .0001), axial location (P &lt; .04), radiation therapy only for local control (P &lt; .009), type of chemotherapy regimen (P &lt; .0001), and poor chemotherapy-induced necrosis (P &lt; .001). After multivariate analysis, the adverse independent prognostic factors were male sex (P &lt; .04), age older than 12 years (P &lt; .001), fever (P &lt; .0002), anemia (P &lt; .02), high serum LDH level (P &lt; .0003), axial location (P &lt; .02), and type of chemotherapy regimen (P &lt; .0003). When the multivariate analysis was restricted to surgically treated patients, the adverse independent prognostic factors were poor chemotherapy-induced necrosis (P &lt; .0001), fever (P &lt; .015), anemia (P &lt; .02), and high serum LDH level (P &lt; .025). CONCLUSION: The prognosis in cases of nonmetastatic Ewing’s sarcoma is influenced by many different clinical and hematologic variables, all of which are to be considered when patients are being stratified according to the risk of relapse. In surgically treated patients, the most important prognostic factor is chemotherapy-induced necrosis.
Abstract 11770: Left Bundle Branch Block Induced by Transcatheter Aortic Valve Implantation Increases Risk for 1-Year All-Cause Mortality
Authors: Leen A Van Garsse, Patrick Houthuizen, Thomas T Poels, Ben M Swinkels, Jurriën M ten Berg, Frank van der Kley, Martin J Schalij, Jan Baan, Ricardo Cocchieri, Guus R Brueren, Bart H van Straten, Peter den Heijer, Mohamed Bentala, Vincent V van Ommen, Jolanda Kluin, Pieter R Stella, Jos G Maessen, Frits W Prinzen
Journal: Circulation (2011)

Introduction: Transcatheter aortic valve implantation (TAVI) is a valuable therapy in selected patients with severe aortic stenosis. However, ∼30% of patients develop a new left bundle branch block...
Most people with insurance from US exchanges are satisfied with coverage, survey finds
Authors: M. McCarthy
Journal: BMJ (2015)

A large majority (74%) of people who bought their health insurance through the exchanges created by the US Affordable Care Act say that their plan’s coverage is “excellent” or “good,” and 59% consider it “excellent” or “good” value for what they pay, a survey by the Kaiser Family Foundation has found.1 

The exchanges were set up by the 2010 health reform law to create online market places where individuals and families can easily compare insurance plans side by side. All plans offered on the exchanges must provide …
Identification of candidate downstream genes for the homeodomain transcription factor Labial in Drosophila through oligonucleotide-array transcript imaging.
Authors: Ronny Leemans, Thomas Loop, Boris Egger, Haiqiong He, Lars Kammermeier, Beate Hartmann, Ullrich Certa, Heinrich Reichert, Frank Hirth
Journal: Genome biology (2001)
Soluble Macrophage Biomarkers Indicate Inflammatory Phenotypes in Patients With Knee Osteoarthritis
Authors: Hikmat N. Daghestani, Carl F. Pieper, Virginia B. Kraus
Journal: Arthritis & Rheumatology (2014)

Objective To evaluate the ability of the macrophage markers CD163 and CD14 to predict different osteoarthritis (OA) phenotypes defined by severity of joint inflammation, radiographic features and progression, and joint pain. Methods We evaluated 2 different cohorts totaling 184 patients with radiographic knee OA. These included 25 patients from a cross‐sectional imaging study for whom there were data on activated macrophages in the knee joint, and 159 patients (134 with 3‐year longitudinal data) from the longitudinal Prediction of Osteoarthritis Progression study. Multivariable linear regression models with generalized estimating equations were used to assess the association of CD163 and CD14 in synovial fluid (SF) and blood with OA phenotypic outcomes. Models were adjusted for age, sex, and body mass index. P values less than or equal to 0.05 were considered significant. Results SF CD14, SF CD163, and serum CD163 were associated with the abundance of activated macrophages in the knee joint capsule and synovium. SF CD14 was positively associated with severity of joint space narrowing and osteophytes in both cohorts. SF and plasma CD14 were positively associated with self‐reported knee pain severity in the imaging study. Both SF CD14 and SF CD163 were positively associated with osteophyte progression. Conclusion Soluble macrophage biomarkers reflected the abundance of activated macrophages and appeared to mediate structural progression (CD163 and CD14) and pain (CD14) in OA knees. These data support the central role of inflammation as a determinant of OA severity, progression risk, and clinical symptoms, and they suggest a means of readily identifying a subset of patients with an active inflammatory state and worse prognosis.
The Role of Decision Aids in Depression Care
Authors: Kurt Kroenke
Journal: JAMA Internal Medicine (2015)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Internal Medicine HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Internal Medicine journal
Obinutuzumab (GA101) plus chlorambucil (Clb) or rituximab (R) plus Clb versus Clb alone in patients with chronic lymphocytic leukemia (CLL) and preexisting medical conditions (comorbidities): Final stage 1 results of the CLL11 (BO21004) phase III trial.
Authors: Valentin Goede, Kirsten Fischer, Kathryn Humphrey, Elina Asikanius, Raymonde Busch, Anja Engelke, Clemens M. Wendtner, Olga Samoylova, Tatiana Chagorova, Marie-Sarah Dilhuydy, Javier De La Serna Torroba, Thomas Illmer, Stephen Opat, Carolyn Owen, Karl A Kreuzer, Anton W Langerak, Matthias Ritgen, Stephan Stilgenbauer, Michael Wenger, Michael Hallek
Journal: Journal of Clinical Oncology (2013)

7004 Background: Chemoimmunotherapy (CIT) is standard of care in young and physically fit patients (pts) with CLL. Development of CIT for older and less fit CLL pts is ongoing, but data from phase III trials are sparse. CLL11 is the largest trial to evaluate three treatments in previously untreated CLL pts with comorbidities: Clb alone, GA101 + Clb (GClb), R + Clb (RClb). The final analysis of CLL11 stage 1 efficacy and safety results is presented here. Methods: Treatment-naïve CLL pts with a Cumulative Illness Rating Scale (CIRS) total score &gt;6 and/or an estimated creatinine clearance (CrCl) &lt;70 mL/min were eligible. Pts received Clb alone (0.5 mg/kg po d1, d15 q28 days, 6 cycles), GClb (100 mg iv d1, 900 mg d2, 1000 mg d8, d15 of cycle 1, 1000 mg d1 cycles 2-6), or RClb (375 mg/m 2 iv d1 cycle 1, 500 mg/m 2 d1 cycles 2-6). Primary endpoint was investigator-assessed progression-free survival (PFS). Results: Median age, CIRS score, and CrCl at baseline were 73 years, 8, and 61.1 mL/min for stage 1a (Clb vs GClb, 356 pts) and 73 years, 8, and 62.1 mL/min for stage 1b (Clb vs RClb, 351 pts, triggered by a different event rate). Key efficacy and safety results are shown in the Table.Grade 3-4 infusion-related reactions with GClb occurred at first infusion only. Management required splitting the first dose over 2 days. Conclusions: CIT with GClb or RClb significantly prolongs PFS vs Clb alone. The results demonstrate that GClb and RClb are very active in CLL and superior treament options in this population. GClb vs RClb will be compared in stage 2 analysis with more follow-up available. Clinical trial information: NCT01010061. [Table: see text]
Next-generation deep-sequencing detects multiple clones of CALR mutations in patients with BCR-ABL1 negative MPN
Authors: S Jeromin, A Kohlmann, M Meggendorfer, S Schindela, K Perglerová, N Nadarajah, W Kern, C Haferlach, T Haferlach, S Schnittger
Journal: Leukemia (2015)
NHS Provision for the Treatment of Ankle Fractures: A Patient Satisfaction Study
Authors: Philip Meredith, N R Gillham
Journal: Journal of the Royal Society of Medicine (1993)

From a clinical audit of the treatment given to 1005 patients suffering from ankle fractures, 507 patients of 626 taken randomly from 15 hospitals were contacted and asked to complete a questionnaire describing and evaluating their experiences. The design of the study aimed in a number of ways to reduce respondents' tendency towards a positive response in completing satisfaction scales. The very high response rate, commentaries and variations in opinions about specific service criteria indicate that the results have a high degree of validity. The generally high rates of satisfaction reported here reflect very well on existing NHS provision for a specific procedure, with the exception of certain hospitals' arrangements for waiting, and the provision of certain types of information. Against general indicators of satisfaction with the management of pain relief in hospitals, that in ankle fracture treatments appears to be exceptionally high. However, it would be valuable to discover why younger patients appear to be strikingly more critical than older patients across the entire range of issues. The inquiry aims to compare findings with studies of other orthopaedic services using a similar elementary methodology as a routine component of clinical audit.
Antibody Therapy Blocks Effects of Traumatic Brain Injury
Authors: Tracy Hampton
Journal: JAMA (2015)

Treating mice with an antibody against the cis form of phosphorylated tau protein (cis P-tau) can prevent some of the pathological changes that occur after traumatic brain injury (TBI), researchers report (Kondo A et al. Nature. doi:10.1038/nature14658 [published online July 15, 2015]).
Abdominal Lymphoma - the Place for Surgery
Authors: A D Baildam, G T Williams, P F Schofield
Journal: Journal of the Royal Society of Medicine (1989)

Gastrointestinal lymphoma (GIL) is rare but may be cured by surgery and chemotherapy. Because symptoms frequently mimic common abdominal conditions, presentation is often to a surgeon. Fifty-five patients with GIL were treated between 1975 and 1984: all underwent operations before the correct diagnosis was made, 22 (40%) as emergencies. Misdiagnosis in 23 (42%) led to a delay in correct treatment of greater than or equal to 6 months from the start of symptoms: in 17 (31%) the delay was greater than or equal to one year. Endoscopy and radiology were inaccurate and suggested peptic ulceration, Crohn's disease or irritable bowel syndrome. The site of disease was usually stomach and duodenum (26, 47%) or ileum and jejunum (29, 53%). The extent of surgical resection was associated with survival at greater than or equal to 3 years-in 16 (29%) who underwent 'complete resection' 14 survived, but only one of 28 survived when the operation was limited to diagnostic biopsy (P less than 0.0001). Most deaths occurred within one year of operation, commonly from perforation or haematemesis from residual mural disease during chemotherapy. In 5 of 11 patients who had biopsy only, CT scans suggested localized disease, and 'complete resection' was achieved at a second laparotomy. Complete resection should be attempted wherever possible before chemotherapy. The place for surgeons with experience is clearly central to the management of this disease.
Abstract 14713: Left Atrial Diameter Predicts Mortaliy in African Americans with Hypertension
Authors: David A Sutter, Athanasios Thomaides, Kyle Hornsby, Abhishek Khemka, Jothiharan Mahenthiran, Irmina Gradus-Pizlo, Harvey Feigenbaum, Stephen Sawada
Journal: Circulation (2010)

Introduction:  Left atrial (LA) dilatation has been shown to be a predictor of adverse outcomes in Caucasian patients with hypertension and other forms of heart disease. Less is known about the prognostic value of LA size in African Americans (AfrAm) and there is evidence that LA remodeling is relatively reduced in AfrAm with heart disease. We investigated the prognostic value of single plane LA dimension in hypertensive AfrAm.   Methods:  Clinical data and two-dimensional echocardiographic measurements were obtained in 583 consecutive AfrAm (mean ejection fraction = 58.6 ± 9.9%) with hypertension undergoing stress echocardiography at an urban community hospital. LA systolic diameter was measured as the maximum dimension in the parasternal long or short-axis view and indexed to body surface area (BSA). Patients were followed for mortality. ROC analysis was used to determine the best predictor of LA size for mortality and Cox regression was used to determine clinical and echocardiographic predictors of mortality.   Results:  LA size above normal values (≥ 2.4 cm/m 2  according to the American Society of Echocardiography guidelines) was found in 9.5% of all patients. During follow-up of 4.5 ± 1.7 years, 85 patients (14.6%) died. LA size had an area under the curve of 0.72 with the best cutoff value of 2.05 cm/m 2 . Cox analysis showed that LA size ≥ 2.05 cm/m 2  (p = 0.013, HR 1.85 [1.14–3.01]), age (p    Conclusions:  LA dilatation is relatively infrequent in hypertensive AfrAm patients when published normal values are used. Single plane LA dimension indexed for BSA has reasonable accuracy for prediction of mortality with the best threshold value residing well within the normal range. LA size was an independent predictor of mortality.
Atrial dysrhythmia control through cardioversion improves sleep disordered breathing in patients with heart failure
Authors: Henrik Fox, Thomas Bitter, Dieter Horstkotte, Olaf Oldenburg
Journal: European Respiratory Journal (2014)

Sleep disordered breathing (SDB) is accompanied with increased risk to develop atrial dysrhythmia such as atrial fibrillation or atrial flutter, especially in heart failure patients. In this study we investigated SDB type and severity in patients with atrial dysrhythmias and we sought to determine an effect of successful cardioversion into sinus rhythm on SDB type and severity.

We enrolled 81 patients prospectively for our study with heart failure symptoms subject to New York Heart Association (NYHA) functional classification II, III or IV. All patients underwent multichannel polygraphy for SDB diagnosis before and immediately (within 12 hours) after electrical cardioversion (CV) into sinus rhythm. All patients were invited to a four week follow up outpatient clinic visit to rescan for atrial dysrhythmia and SDB.

A total of 95.5 % of patients with atrial dysrhythmia had SDB with a Apnea-Hypopnea-Index (AHI) of ≥ 5/h; 40.7 % had obstructive SDB, 54.3 % had central SDB. Directly after cardioversion AHI was found significantly dropped down, from 22.9 ± 16.5 /h to 16.2 ± 11.1 /h, p<0.005). When scheduled for a four week follow-up, AHI was found back at similar levels than before CV (AHI 25.3 ± 15.4). 78.7 % maintained sinus rhythm in the outpatient setting at four weeks, 21.3 % developed atrial dysrhythmia reoccurrence.

SDB was found at an unexpected high prevalence in HF patients with atrial dysrhythmia. Cardioversion into sinus rhythm improved SDB significantly, but SDB severity was found at comparable levels to initial investigations at a four week follow up.