SYSTEMIC LUPUS ERYTHEMATOSUS: A COMPLEX AUTO-IMMUNE DISORDER?
Authors: W DAMESHEK
Journal: Annals of Internal Medicine (1958)

Article1 April 1958SYSTEMIC LUPUS ERYTHEMATOSUS: A COMPLEX AUTO-IMMUNE DISORDER?WILLIAM DAMESHEK, M.D., F.A.C.P.WILLIAM DAMESHEK, M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-48-4-707 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptINTRODUCTIONSystemic (disseminated) lupus erythematosus has been known for at least 50 years, but its exact nature and the pathogenetic mechanisms bringing it about are almost as obscure now as they were when the disease was first described. Considered a rarity for the first three decades of the present century, its incidence seems to be increasing steadily, although whether this is actually so or the result of better recognition is difficult to state.Systemic lupus must still be classed as a complex disorder of obscure origin. 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Author, Article, and Disclosure InformationAffiliations: Boston, Massachusetts*Presented at the Thirty-eighth Annual Session of The American College of Physicians, Boston, Massachusetts, April 12, 1957.From the Blood Research Laboratory, a unit of the Ziskind Laboratories, New England Center Hospital, and the Department of Medicine, Tufts University School of Medicine.†Aided by a grant from the U. S. Public Health Service, National Institutes of Health, National Heart Institute, Grant No. H-2021 (C2).Requests for reprints should be addressed to William Dameshek, M.D., Director, Blood Research Laboratory, New England Center Hospital, Harrison Avenue and Bennett Street, Boston 11, Massachusetts. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byMaternal Diseases Complicating Pregnancy: Diabetes, Tumors, Preeclampsia, Lupus AnticoagulantEvolving Connective Tissue Disease Influenced by SplenectomyThe Significance of Auto-Immune DiseaseAntiphospholipid antibodies: discovery, definitions, detection and diseaseMaternal Diseases Complicating Pregnancy: Diabetes, Tumors, Preeclampsia, Lupus AnticoagulantMaternal Diseases Complicating Pregnancy: Diabetes, Tumors, Preeclampsia, Lupus AnticoagulantHypoprothrombinemia in childhood systemic lupus erythematosusSurgical treatment of immune thrombocytopenic purpuraLupus Erythematosus and Lupus AnticoagulantDisorders of hemostatic function in patients with systemic lupus erythematosusMaternal Diseases Complicating Pregnancy: Diabetes, Tumors, Preeclampsia, Lupus AnticoagulantBIBLIOGRAPHYIMMUNOPATHOLOGICAL INVESTIGATIONS IN THE SENEARUSHER SYNDROME (COEXISTENCE OF PEMPHIGUS AND LUPUS ERYTHEMATOSUS)Niere bei Tumoren, Blutkrankheiten und ParaproteinämienSystemic lupus erythematosus with circulating anticoagulant discovered after postextraction hemorrhageThe Platelet Destruction Site in Thrombocytopenic PurpurasThe Autoimmune DiseasesSignificance of Morphologic ThyroiditisKENNETH L. BECKER, M.D., JACK L. TITUS, M.D., PH.D., LEWIS B. WOOLNER, M.D., WILLIAM M. MCCONAHEY, M.D.Immunity and Systemic Lupus ErythematosusAUTOIMMUNE DISEASES IN DOMESTIC ANIMALS*INDUCTION OF A DISEASE RESEMBLING SYSTEMIC LUPUS ERYTHEMATOSUS IN LATER STAGE OF PROLONGED SENSITIZATION IN RABBITS*Erythematodes visceralis und TuberkuloseThe Association of Chronic "Nonspecific" Inflammatory Bowel Disease with Lupus ErythematosusDONALD J. KURLANDER, M.D., JOSEPH B. KIRSNER, M.D., PH.D.“Acquired” antibody hemolytic anemia and familial aberrations in gamma globulinsREFERENCESPsychic Disorders in Disseminated Lupus ErythematosusCurrent Concepts of the Pathogenesis of the So-Called Collagen DiseasesThrombocytopeniaA Critical Look at the Splenectomy-S.L.E. ControversyLupus ErythematosusAutoimmunity and DiseaseHepatitis Associated with Disseminated Lupus ErythematosusChronic liver disease in young peopleAnatomical Findings in a Case of Schönlein-Henoch Syndrome: Relationship of this Condition to Collagen DiseasesThe FII agglutinating factors in serums of patients with non-rheumatic diseasesCasualty DepartmentsSystemic Lupus ErythematosusImmunological Aspects of Rheumatoid Disease: A ReviewPROGRESS IN THE UNDERSTANDING OF LUPUS ERYTHEMATOSUS. *A Study on the Onset and Prognosis of Acute Vascular Purpura (the Schönlein-Henoch Syndrome) in ChildrenAUTO-IMMUNIZATION AND AUTO-ANTIBODIESPAUL W. CLOUGH, M.D.SYSTEMIC LUPUS ERYTHEMATOSUS AFTER "IDIOPATHIC" THROMBOCYTOPENIC PURPURA: A REVIEW. A study of systemic lupus erythematosus occurring after 78 splenectomies for "idiopathic" thrombocytopenic purpura, with a review of the pertinent literature*†YALE RABINOWITZ, M.D., WILLIAM DAMESHEK, F.A.C.P.ThrombocytopathienPararheumatische Krankheiten (Sogenannte Kollagenkrankheiten)Systemic lupus erythematosusTHE USE OF CORTICOSTEROIDS IN HEMATOLOGICAL THERAPY*Serum Complement, Rheumatoid Factor, and Other Serum Proteins in Rheumatoid Disease and Systemic Lupus ErythematosusNucleoprotein-Latex Agglutination Test in Connective Tissue DiseasesSerum responses in rheumatoid arthritisTwo Auto-Immune Diseases in one PatientLupus erythematosus visceralisHepatitis and Cirrhosis in Women with Positive Clot Tests for Lupus ErythematosusTHE SIGNIFICANCE OF THE LUPUS GLOBULIN-NUCLEOPROTEIN REACTION*†GEORGE J. FRIOU, M.D. 1 April 1958Volume 48, Issue 4Page: 707-730KeywordsAntigensBlood plasmaHematologic testsHemolytic anemiaHospital medicineLupus erythematosusPathogensResearch laboratoriesSyphilisSystemic lupus erythematosus Issue Published: 1 April 1958 Copyright & PermissionsCopyright ©, 1958, by The American College of PhysiciansPDF downloadLoading ...