Optimal Duration of Treatment for Kidney Infection
Authors: ALLAN R. RONALD
Journal: Annals of Internal Medicine (1987)

Editorials1 March 1987Optimal Duration of Treatment for Kidney InfectionALLAN R. RONALD, M.D.ALLAN R. RONALD, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-106-3-467 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptPrescribing an antimicrobial agent for a patient with a bacterial urinary tract infection is generally straightforward. One of several agents with a wide spectrum of activity against most urinary tract pathogens can be chosen with anticipation of a satisfactory response. Acute symptoms usually resolve within 24 hours, and a urine culture is predictably negative within a few hours after initiation of therapy. The decision as to length of therapy to cure the infection is more controversial. The performance of definitive studies to determine the necessary treatment duration for cure has not been seen to be an important goal for most...References1. BUCKWOLDLUDWIGHARDING FPG. Therapy for acute cystitis in adult women: randomized comparison of single-dose sulfisoxazole vs trimethoprim-sulfamethoxazole. JAMA. 1982;247:1839-42. CrossrefMedlineGoogle Scholar2. TOLKOFF-RUBINWILSONZUROMSKISJACOBYMARTINRUBIN NMPIAR. Single-dose amoxicillin therapy of acute uncomplicated urinary tract infections in women. Antimicrob Agents Chemother. 1984;25:626-9. CrossrefMedlineGoogle Scholar3. HOOTONRUNNINGSTAMM TKW. Single-dose therapy for cystitis in women: a comparison of trimethoprim-sulfamethoxazole, amoxicillin, and cyclacillin. JAMA. 1985;253:387-90. CrossrefMedlineGoogle Scholar4. TURCKBROWDERLINDEMEYERBROWNANDERSONPETERSDORF MARNKR. Failure of prolonged treatment of chronic urinary-tract infections with antibiotics. N Engl J Med. 1962;267:999-1006. CrossrefMedlineGoogle Scholar5. MCCABEJACKSON WG. Treatment of pyelonephritis: bacterial, drug and host factors in success or failure among 252 patients. N Engl J Med. 1965;272:1037-44. CrossrefGoogle Scholar6. TURCKANDERSONPETERSDORF MKR. Relapse and reinfection in chronic bacteriuria. N Engl J Med. 1966;275:70-3. CrossrefMedlineGoogle Scholar7. PREIKSAITISTHOMPSONHARDINGMARRIEHOBANRONALD JLGTSA. A comparison of the efficacy of nalidixic acid and cephalexin in bacteriuric women and their effect on fecal and periurethral carriage of Enterobacteriaceae. J Infect Dis. 1981;143:603-8. CrossrefMedlineGoogle Scholar8. GUTMANTURCKPETERSDORFWEDGWOOD IMRR. Significance of bacterial variants in urine of patients with chronic bacteriuria. J Clin Invest. 1965;44:1945-52. CrossrefMedlineGoogle Scholar9. STAMMMCKEVITTCOUNTS WMG. Acute renal infection in women: treatment with trimethoprim-sulfamethoxazole or ampicillin in a randomized trial of two or six weeks. Ann Intern Med. 1987; 106:341-5. LinkGoogle Scholar10. SMITHJONESREEDTICEDEUPREEKAIJSER JSWARB. Recurrent urinary tract infections in men: characteristics and response to therapy. Ann Intern Med. 1979;91:544-8. LinkGoogle Scholar11. GLECKMANCROWLEYNATSIOS RMG. Therapy of recurrent invasive urinary-tract infections in men. N Engl J Med. 1979;301:878-80. CrossrefMedlineGoogle Scholar12. NORDENSTAMBRANDBERGODENSVANBORG EDENSVANBORG GCACA. Bacteriuria and mortality in an elderly population. N Engl J Med. 1986;314:1152-6. CrossrefMedlineGoogle Scholar13. HARDINGBUCKWOLDMARRIETHOMPSONLIGHTRONALD GFTLRA. Prophylaxis of recurrent urinary tract infection in female patients: efficacy of low-dose, thrice-weekly therapy with trimethoprim-sulfamethoxazole. JAMA. 1979;242:1975-7. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: The University of Manitoba Health Sciences Centre Winnipeg, Manitoba Canada PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byTime courses of bacterial density in urine during antibacterial chemotherapy and influential factors in patients having positive bacteriuria with a complicated urinary tractAntibiotic overuse versus chronic suppressionCurrent Cost-Effective Management of Urinary Tract InfectionsNosocomial Infections in the ICUEVALUATION OF AND ANTIMICROBIAL THERAPY FOR RECURRENT URINARY TRACT INFECTIONS IN WOMENDIAGNOSIS AND TREATMENT OF UNCOMPLICATED URINARY TRACT INFECTIONAntimicrobial agents are the mainstay for managing UTIsCurrent concepts in the treatment of urinary tract infections and prostatitisShort-course versus long-course antibiotic treatment of spontaneous bacterial peritonitisBacteriuria in elderly female subjectsManagement of Acute Uncomplicated Urinary Tract Infection in AdultsUrinary Tract Infection: Economic ConsiderationsAntibiothérapie des infections urinaires : textes du consensusLes nouvelles molécules sont-elles susceptibles de modifier les schémas thérapeutiques des infections urinaires hautes de l'adulte ?Urinary Tract Infections in PregnancyReview of published studies on single dose therapy of urinary tract infectionsUrinary Tract Infections in Women: Diagnosis and TreatmentJames R. Johnson, MD, Walter E. Stamm, MDUrinary Tract Infections in Men Epidemiology, Pathophysiology, Diagnosis, and TreatmentBenjamin A. Lipsky, MDSouthwestern Internal Medicine Conference: Prognosis in Pyelonephritis: Promise or Progress?Ciprofloxacin: Chemistry, Mechanism of Action, Resistance, Antimicrobial Spectrum, Pharmacokinetics, Clinical Trials, and Adverse ReactionsDiagnosis and Treatment of Acute Urinary Tract InfectionsRecurrent Urinary Tract Infection in Adult Women: Diagnosis and TreatmentCommentary 4 1 March 1987Volume 106, Issue 3Page: 467-468KeywordsAntimicrobialsKidneysPathogensUrinary tract infectionsUrine Issue Published: 1 March 1987 PDF downloadLoading ...