tbuckley/cabot-search huggingface dataset:
Unusual Length of Funis.
Authors: JUNIUS C. HOAG
Journal: JAMA (1889)

<h3>To the Editor:</h3> —I wish to report a case which, although by no means unique, is, nevertheless, not without interest. I recently attended a young woman, 22 years of age, in her first confinement. She was of slight figure and weighed less than 100 pounds. The child (which was found to weigh 9½ pounds) was born in a condition of<i>asphyxia livida</i>, a condition produced by reason of a coiling of the funis around the neck. There were<i>five</i>of these coils, drawn very tight, notwithstanding which circumstance there was an abundance of slack left. The child was resuscitated without much difficulty, and in half an hour the placenta was delivered by Crede's method. The latter was of unusual size, being far larger than any other placenta I ever saw, although, as usual in such cases, it was by no means proportionately thick. When expelled it was rolled up like
Two arrested in US for selling organs for transplantation
Authors: D. Josefson
Journal: BMJ (1998)

The Federal Bureau of Investigations has arrested two Chinese men for conspiring to sell organs for transplantation in the United States. The organs being offered were allegedly harvested from executed Chinese prisoners.

The two arrested were Wang Chengyong, a former criminal prosecutor from Hainan Province, and Xingqi Fu, a Chinese citizen currently living in New York. The two men allegedly offered corneas, lungs, livers, a kidney, a pancreas, and skin for …
Fibroblast Network in Rabbit Sinoatrial Node
Authors: Patrizia Camelliti, Colin R. Green, Ian LeGrice, Peter Kohl
Journal: Circulation Research (2004)

Cardiomyocytes form a conducting network that is assumed to be electrically isolated from nonmyocytes in vivo. In cell culture, however, cardiac fibroblasts can contribute to the spread of excitation via functional gap junctions with cardiomyocytes. To assess the ability of fibroblasts to form gap junctions in vivo, we combine in situ detection of connexins in rabbit sinoatrial node (a tissue that is particularly rich in fibroblasts) with identification of myocytes and fibroblasts using immunohistochemical labeling and confocal microscopy. We distinguish two spatially distinct fibroblast populations expressing different connexins: fibroblasts surrounded by other fibroblasts preferentially express connexin40, whereas fibroblasts that are intermingled with myocytes largely express connexin45. Functionality of homogeneous and heterogeneous cell coupling was investigated by dye transfer in sinoatrial node tissue explants. These studies reveal spread of Lucifer yellow, predominantly along extended threads of interconnected fibroblasts (probably via connexin40), and occasionally between neighboring fibroblasts and myocytes (probably via connexin45). Our findings show that cardiac fibroblasts form a coupled network of cells, which may be functionally linked to myocytes in rabbit SAN.
GPs are told to tender for their own practice
Authors: Zosia Kmietowicz
Journal: BMJ (2006)

Ashley Liston seems like a model GP. He has an altruistic streak, inspired he says by Julian Tudor Hart, the socialist doctor and passionate advocate of the NHS who worked as a GP in Wales for 30 years. Two years ago Dr Liston gave up his position as principal GP in a practice in a comfortable Newcastle neighbourhood, where he had worked for eight years, to become a salaried GP at a practice that had relied on locums for 30 months.

“I wanted to maximise the benefits of my skills without going abroad. I wanted to make a difference and to have a personal challenge,” he said.

If the feedback from his patients at the Encompass practice in Washington, Tyne and Wear, is anything to …
Quantitative Radioautography of Sugar Transport in Intestinal Biopsies from Normal Humans and a Patient with Glucose-Galactose Malabsorption
Authors: Charles E. Stirling, Albert J. Schneider, Ming-Der Wong, William B. Kinter
Journal: Journal of Clinical Investigation (1972)

Both galactose accumulation and phlorizin binding by columnar epithelial cells have been investigated in vitro with a recently developed technique for high-resolution, plastic-section radioautography which is particularly suited to small quantities of biopsy tissue. Grain density analysis of the radioautographs provides definitive support for the view that the cellular mechanisms underlying glucose-galactose absorption in laboratory animals are fully applicable to the small intestine of man. Even the number of sugar carriers at the microvillar membrane appears similar and the major quantitative difference, lower affinity for phlorizin in man, correlates with the finding that phlorizin is also a less potent inhibitor of uphill, galactose transport at the microvilli. In addition, radioautographs of biopsies taken 2 yr apart from a patient with glucose-galactose malabsorption provide evidence that the cellular defect in this inborn error of transport is a persistent reduction in the number of functioning sugar carriers at the microvillar membrane.
Acute otitis media in children
Authors: A. Majeed, T. Harris
Journal: BMJ (1997)

Acute otitis media in childrenFewer children should be treated with antibiotics M ost general practitioners in Britain would treat a child with acute otitis media with antibiotics. 1 However, papers published recently in the BMJ cast doubt on the effectiveness of this policy. 2 3The authors concluded that antibiotics offer only limited benefits and that most children with acute otitis media can be managed without them.If justified, the authors' conclusions would have important implications for British general practice.Acute otitis media is one of the commonest childhood problems seen by general practitioners.Every year, about 10% of under 5 year olds and 3.5% of 5-15 year olds are seen by their general practitioner at least once with the condition.Hence, a typical general practitioner will see about 20 children with acute otitis media every year. 4 As there are more than 30 000 general practitioners in Britain, a more restricted role for antibiotics in the management of acute otitis media would lead to a substantial reduction in the prescribing of antibiotics.This in turn would result in fewer children experiencing the side effects of antibiotics and less likelihood of antibiotic resistance developing.The potential benefits of reduced antibiotic prescribing are clear, but are the authors of the two papers right to call for a more restricted role for antibiotics in the management of acute otitis media?Del Mar and colleagues carried out a meta-analysis of six randomised controlled trials. 2 They found no difference in the percentage of children who still had pain 24 hours after starting treatment (39% in the treatment group v 40% in the control group).However, after two to seven days, fewer children in the antibiotic group had pain than children in the placebo group (9.7% v 14.3%).Moreover, the risk of contralateral otitis media was also reduced by 43%.There was no significant difference in the prevalence of deafness at one month or in the percentage of children with recurrent acute otitis media.Del Mar et al concluded that the early use of antibiotics provides only modest benefits, with 17 children requiring treatment at first presentation to prevent one child experiencing pain at two to seven days.However, their meta-analysis had only limited power to show whether antibiotics had an effect on some important outcomes.Thus, some differences which may be clinically significant did not achieve statistical significance-for example, a 50% reduction in the risk of perforation of the ear drum and a 20% reduction in deafness at three months in those treated with antibiotics.Furthermore, all of the trials in the meta-analysis were too small to look at rare complications like mastoiditis and meningitis.
Ser <sup>1292</sup> Autophosphorylation Is an Indicator of LRRK2 Kinase Activity and Contributes to the Cellular Effects of PD Mutations
Authors: Zejuan Sheng, Shuo Zhang, Daisy Bustos, Tracy Kleinheinz, Claire E. Le Pichon, Sara L. Dominguez, Hilda O. Solanoy, Jason Drummond, Xiaolin Zhang, Xiao Ding, Fang Cai, Qinghua Song, Xianting Li, Zhenyu Yue, Marcel P. van der Brug, Daniel J. Burdick, Janet Gunzner-Toste, Huifen Chen, Xingrong Liu, Anthony A. Estrada, Zachary K. Sweeney, Kimberly Scearce-Levie, John G. Moffat, Donald S. Kirkpatrick, Haitao Zhu
Journal: Science Translational Medicine (2012)

LRRK2 autophosphorylation on Ser 1292 may be a useful indicator of kinase activity, providing a readout for screening candidate LRRK2 inhibitors.
Economical test methods for developmental neurobehavioral toxicity.
Authors: G Bignami
Journal: Environmental Health Perspectives (1996)

The assessment of behavioral changes produced by prenatal or early postnatal exposure to potentially noxious agents requires both the designing of ad hoc tests and the adaptation of tests for adult animals to the characteristics of successive developmental stages. The experience in designing tests is still more limited than in the adaptation of tests, but several tests have already proven their usefulness; some examples are the suckling test, the homing test, and evaluations of dam-pup and pup-pup interactions. Functional observational batteries can exploit the development at specified postnatal ages of several reflexes and responses that are absent at birth in altricial rodent species with a short pregnancy such as the rat and the mouse. In neonates, the assessment of early treatment effects can rely not only on deviations from normal responding but also on changes in the time of appearance of otherwise normal response patterns. The same applies to other end points such as responses to pain and various types of spontaneous motor/exploratory activities, including reactivity to a variety of drug challenges that can provide information on the regulatory systems whose development may be affected by early treatments. In particular, the analysis of ontogenetic dissociations (i.e., differential early treatment effects depending jointly on developmental stage at the time of exposure, age of testing, and response end point) can be of considerable value in the study of treatments' mechanisms of action. Overall, it appears that behavioral teratological assessments can be effectively used both proactively, i.e., in risk assessment prior to any human exposure, and reactively. In the latter case, these assessments could have special value in the face of agents suspected to produce borderline changes in developing humans, whose innocuousness or noxiousness can be difficult to establish in the absence of hard evidence of teratogenicity.
The Constitutionality of the Individual Mandate for Health Insurance
Authors: Jack M. Balkin
Journal: New England Journal of Medicine (2010)

Once President Barack Obama and Democrats in Congress have passed a health care reform bill, conservative groups are likely to challenge parts of it as unconstitutional, arguing that it oversteps Congress's powers. A key target will be the individual mandate, which is designed to coax uninsured persons into purchasing insurance.The term “individual mandate” is misleading for two reasons. First, the law would not actually require all individuals to purchase insurance. The mandate would not apply to dependents, persons receiving Medicare or Medicaid, military families, persons living overseas, persons with religious objections, or persons who already get health insurance from . . .
Improved method of recovering Toxocara species ova from soil.
Authors: A W Woodruff, A I Shah
Journal: BMJ (1976)

Perforation of ileal duplication in old ageIntestinal duplications have an individual muscle coat, submucosa, and an epithelium corresponding to the structure of the adjacent bowel, although heterotopic mucosa is common.Such anomalies generally lie within the mesentery or mediastinum and may com- municate with the bowel or remain discrete.They are either tubular or cystic in nature.Most are found during childhood, often at opera- tion.Out of 315 cases recorded up to 1950, Dohn and Poulsen1 found that 30% were first diagnosed in patients aged 16 and only 5% in patients over 50.Anderson et a12 reviewed 63 cases in adults recorded between 1949 and 1959; the oldest patient was 68, the condition being found incidentally at necropsy.We report a case of peritonitis occur- ring after perforation of an ileal duplication in old age. Case reportAn 81-year-old man was admitted to hospital as an emergency case with a
Plasma-Cell Dyscrasia and Peripheral Neuropathy with a Monoclonal Antibody to Peripheral-Nerve Myelin
Authors: Norman Latov, William H. Sherman, Raffaello Nemni, Giuliana Galassi, Joanna S. Shyong, Audrey S. Penn, Leonard Chess, Marcelo R. Olarte, Lewis P. Rowland, Elliott F. Osserman
Journal: New England Journal of Medicine (1980)

PERIPHERAL neuropathy has been associated with plasma-cell dyscrasia, 1 but it is not known whether the monoclonal immunoglobulins react with peripheral-nerve antigens. We report on a patient with a peripheral neuropathy associated with an IgMk monoclonal protein, in whom pathological and immunological studies indicated that the IgMk antibody was directed against peripheral-nerve myelin, as shown by complement fixation and immunoabsorption.Case ReportThe patient was a 45-year-old man admitted for evaluation of a slowly progressive sensory-motor neuropathy of 11 years' duration. On examination there was moderate to severe weakness and atrophy of the muscles of the hands and distal parts of . . .
Oncogenic NRAS signaling differentially regulates survival and proliferation in melanoma
Authors: Lawrence N Kwong, James C Costello, Huiyun Liu, Shan Jiang, Timothy L Helms, Aliete E Langsdorf, David Jakubosky, Giannicola Genovese, Florian L Muller, Joseph H Jeong, Ryan P Bender, Gerald C Chu, Keith T Flaherty, Jennifer A Wargo, James J Collins, Lynda Chin
Journal: Nature Medicine (2012)
THE TREATMENT OF VITILIGO WITH A COMBINATION OF PSORALENS AND QUINOLINES.
Authors: ABDEL MONEM EL-MOFTY
Journal: British Journal of Dermatology (1964)

Journal Article THE TREATMENT OF VITILIGO WITH A COMBINATION OF PSORALENS AND QUINOLINES. Get access ABDEL MONEM EL‐MOFTY ABDEL MONEM EL‐MOFTY Assistant Professor of Dermatology, Kosr El‐Aini, Faculty of Medicine, Cairo University Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 76, Issue 2, 1 February 1964, Pages 56–62, https://doi.org/10.1111/j.1365-2133.1964.tb14475.x Published: 01 February 1964
Hispanic/Latino Health Issues Explored
Authors: Marsha F. Goldsmith
Journal: JAMA (1993)

SHEER NUMBERS compel interest. At the recent Midwest Regional Meeting on Hispanic/Latino Health, held in Chicago, Ill—part of the Surgeon General's National Hispanic/Latino Health Initiative that Antonia C. Novello, MD, MPH (Surgeon General of the US Public Health Service), introduced with a workshop in Washington, DC, last September—the ever-increasing presence of people of Hispanic descent in American society was a major theme. Today there are 22 million such persons in the United States, two thirds of them born here. By the year 2000 there will be 31 million, and by 2050 the projected figure is 96 million. Hispanics are the single largest and also the youngest ethnic minority in the country (their number has grown 50% in the last decade and one third are 18 to 24 years of age), they have the highest fertility rate and largest families, and lack of adequate health care is but one of their
Abstract 5704: Curcumin-folate conjugate for increased bioavailability and targeted delivery of curcumin to cancer cells
Authors: Bhudev C. Das, Abhishek Tyagi, Rakesh Kumar, Alok C. Bharti, Ramendra K. Singh
Journal: Cancer Research (2012)

Abstract Specific types of high risk Human Papillomavirus (HR-HPV) types, particularly the HPV type 16 and HPV 18 are known to cause cervical cancer. The expression of two viral oncogenes E6 and E7 responsible for tumorigenic transformation, is mainly dependent on specific host-cell transcription factor, Activator Protein 1 (AP-1) which acts as a signaling epicenter for cervical cancer. Although recently two prophylactic HPV vaccines have been developed, there is no therapeutic molecule available for the treatment of cervical lesions. We demonstrate that Curcumin (Diferuloylmethane), a yellow pigment, used in traditional medicines and present in the dietary spice turmeric (Curcuma longa), can selectively down regulate HPV 18 transcription as well as AP-1 binding activity. Curcumin can also reverse the expression dynamics of c-fos and fra-1 in tumorigenic HeLa cells by mimicking their expression pattern in normal cells. But the bioavailability of curcumin is extremely poor due to its hydrophobicity, rapid metabolism and lack of specificity in targeting cancer cells. Therefore, a folic acid-curcumin conjugate for mutation has been developed by attaching one molecule of curcumin with two molecules of folic acid (Cur-2FA) to make curcumin hydrophilic, enhance its bioavailability and to target only cancer cells which specifically express high level of folate receptors. The effect of both native curcumin and Cur-2FA on HPV and AP-1 has been analyzed in HPV positive cervical cancer and HPV negative breast cancer cell lines, by band shift assay, confocal microscopy, flow cytometry and western blotting including their cytotoxic potential and targeted cellular uptake of curcumin. In comparison to native curcumin, curcumin-2FA has been found to be atleast two times more effective in inducing down regulation of HPV transcription, AP-1 activity and expression of its components particularly c-fos and fra-1. Curcumin-2FA was found to be more potent than curcumin in inducing apoptosis, inhibits tumor cell proliferation and Cur-2FA conjugate was specifically taken up by cancer cells. In mice, curcumin-2FA was more bioavailable and had a longer half-life than curcumin. We demonstrate that this nontoxic low molecular weight curcumin-2Folic acid conjugate formulation specifically targets cancer cells which overexpress high affinity folate receptor and enhanced cellular uptake facilitating increased bioavailability and targeted delivery to cancer cells. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 103rd Annual Meeting of the American Association for Cancer Research; 2012 Mar 31-Apr 4; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2012;72(8 Suppl):Abstract nr 5704. doi:1538-7445.AM2012-5704
Volitional and Emotional Supranuclear Facial Weakness
Authors: R T Ross, R Mathiesen
Journal: New England Journal of Medicine (1998)

Figure 1. A 50-year-old man with a primary lymphoma of the central nervous system in the left thalamus had a normal, symmetric face at rest (Panel A) and on voluntary movement, showing his teeth (Panel B), but had weakness of the lower right side of the face on reflex smiling (Panel C). His family reported that the weakness was of recent onset. The facial asymmetry improved after chemotherapy and radiation, but regressed when treatment was discontinued. In contrast, a 72-year-old woman with hypertension and an infarct in the territory of the left middle cerebral artery had the more commonly seen . . .
microRNA expression in the biology, prognosis, and therapy of Waldenström macroglobulinemia
Authors: Aldo M. Roccaro, Antonio Sacco, Changzhong Chen, Judith Runnels, Xavier Leleu, Feda Azab, Abdel Kareem Azab, Xiaoying Jia, Hai T. Ngo, Molly R. Melhem, Nicholas Burwick, Lyuba Varticovski, Carl D. Novina, Barrett J. Rollins, Kenneth C. Anderson, Irene M. Ghobrial
Journal: Blood (2008)
Gluten-Sensitive Enteropathy with Osteomalacia but without Steatorrhea
Authors: Arthur J. Moss, Christine Waterhouse, Roger Terry
Journal: New England Journal of Medicine (1965)

GLUTEN-sensitive enteropathy with steatorrhea (celiac disease) is a well defined clinical entity, and selective absorptive deficiencies may exist for many years before the discovery of the overt enteropathy.1 2 3 4 Osteomalacia, which may occur with chronic enteropathy, has generally been attributed to vitamin D malabsorption accompanying the steatorrhea. To our knowledge, severe bone disease in gluten-sensitive enteropathy without steatorrhea has not previously been reported. In the case presented below, osteomalacia, osteoporosis and multiple bone fractures were the principal manifestations of a gluten-sensitive enteropathy; the diagnosis of a malabsorption syndrome was not initially entertained because of the absence of steatorrhea or diarrhea. The . . .
Book Review Clinical Hematology and Fundamentals of Hemostasis Second edition. Edited by Denise M. Harmening. 657 pp., illustrated. Philadelphia, F.A. Davis, 1992. $51.95. ISBN 0–8036–4603–8 . Clinical Hematology: Principles, procedures, correlations Edited by Cheryl A. Lotspeich-Steininger, E. Anne Stiene-Martin, and John A. Koepke. 757 pp., illustrated. Philadelphia, J.B. Lippincott, 1992. $49.95. ISBN 0–397–54806–0 .
Authors: Philip R. Daoust
Journal: New England Journal of Medicine (1992)
830-2 Platelet glycoprotein IIb/IIIa receptor inhibition as adjunctive treatment during saphenous vein graft stenting: Differential effects after randomization to occlusion or filter-based embolic protection
Authors: Michael Jonas, Gregg W Stone, James Hermiller, Robert Feldman, Patrick Hall, Robert Haber, Zaki Masud, Patrick Cambier, Ron P Caputo, Mark Turco, Richard Kovach, Bruce Brodie, Howard C Hermann, David Cox, Roxana Mehran, Campbell Rogers
Journal: Journal of the American College of Cardiology (2004)
Commentary: Telemedicine trials--clinical pull or technology push?
Authors: J. C Wyatt
Journal: BMJ (1996)

Telemedicine—remote consultation via an electronic link—is now feasible and increasingly easy to realise. But is it necessary for patients, doctors, or the health service? Randomised trials of telemedicine were first performed two decades ago,1 2 but some recent studies seem to have been driven by technology push rather than clinical pull.3 4 5 These studies give inadequate attention to three fundamental aspects of any trial: defining what is done, to whom it is done, and what is measured.6

Doctors conducted remote consultations long before the advent of telemedicine by diagnosing a sick patient over the telephone or reviewing mailed histology slides. The unique feature of telemedicine is the fast two way electronic network that allows interactive communication such as video conferencing.5 To show that telemedicine confers benefit we must compare electronic means for transferring information with the most appropriate alternative.2 This means comparing teledermatology with a …
Gene expression profiling of follicular lymphoma and normal germinal center B cells using cDNA arrays
Authors: Hervé Husson, Elizabeth G. Carideo, Donna Neuberg, Joachim Schultze, Olivier Munoz, Peter W. Marks, John W. Donovan, Antoinette C. Chillemi, Peter O'Connell, Arnold S. Freedman
Journal: Blood (2002)