tbuckley/cabot-search huggingface dataset:
Effects of Cholesterol and Inflammation-Sensitive Plasma Proteins on Incidence of Myocardial Infarction and Stroke in Men
Authors: G. Engström, P. Lind, B. Hedblad, L. Stavenow, L. Janzon, F. Lindgärde
Journal: Circulation (2002)

Background — Although cholesterol is a major cardiovascular risk factor, its association with stroke remains controversial. This study explored whether the cholesterol-related incidence of stroke and myocardial infarction is modified by plasma markers of inflammation in a large, population-based cohort with a long follow-up. Methods and Results — Plasma cholesterol and 5 inflammation-sensitive plasma proteins (ISP) (fibrinogen, α 1 -antitrypsin, haptoglobin, ceruloplasmin, and orosomucoid) were determined in 6063 healthy men, 28 to 61 years of age. The incidence of stroke, cardiac events (fatal and nonfatal), and cardiovascular deaths was compared between groups defined by levels of cholesterol and ISP. Mean follow-up was 18.7 years. High ISP level was defined as 2 to 5 ISP in the top quartile. High cholesterol was associated with higher levels of ISP. Hypercholesterolemia (≥6.5 mmol/L, 251 mg/dL) was associated with an increased incidence of ischemic stroke and cardiac events and with a reduced incidence of intracerebral hemorrhage. The ISP levels modified these associations. After risk factor adjustment, men with hypercholesterolemia and high ISP levels had a significantly higher risk of cardiovascular death (relative risk [RR]=2.4; CI, 1.8 to 3.3), cardiac events (RR=2.3; CI, 1.8 to 3.0), and ischemic stroke (RR=2.1; CI, 1.4 to 3.3) than men with normal cholesterol and low ISP levels. In the absence of high ISP levels, hypercholesterolemia was associated with a moderately higher risk of cardiovascular death (RR=1.4; CI, 1.0 to 2.0) and cardiac events (RR=1.5; CI, 1.2 to 1.9) but not significantly with ischemic stroke (RR=1.25; CI, 0.8 to 2.0). Conclusions — Hypercholesterolemia is associated with high plasma levels of ISP. These proteins increase the cholesterol-related incidence of cardiovascular diseases. In the absence of elevated ISP levels, no statistically confirmed association was found between hypercholesterolemia and ischemic stroke.
Endocarditis From Serratia marcescens
Authors: Richard Quintiliani
Journal: JAMA (1969)

Despite the increasing frequency of nosocomial infections due to nonpigmented strains of<i>Serratia marcescens</i>, infective endocarditis from this organism is rare. This communication adds three such cases to the previously reported four. Five of the seven patients succumbed to infection. Some predisposing factor could be identified in all seven. Therapy was extremely difficult because of resistance to antibiotics and persistence of infection despite the use of appropriate chemotherapeutic agents, including nalidixic acid intravenously, used unsuccessfully in two patients. The difficulty in eradicating this infection once it has become established on a prosthetic valve is evident. The possibility that intravenous foreign bodies are a source of infection must be considered.
Opsoclonus in salmonella infection.
Authors: A Vejjajiva, P Lerdverasirikul
Journal: BMJ (1977)

function tests were abnormal (bilirubin 17 IUJ, alkaline phosphatase 66 IU/l, aspartate transaminase 81 IU/1, gammaglutamyltranspeptidase 124 IU/1).The result of an intravenous pyelogram was normal.At operation the choledochus cyst was considerably shrunken, and was seen to have a definitely thickened wall.The gall bladder was not found and was therefore presumed to have been removed at the first laparotomy.The liver felt firm but was not obviously enlarged.There was considerable splenomegaly.A choledocho- cystojejunostomy with Roux-en-Y anastomosis was performed.Histological examination of an operative liver biopsy specimen showed the typical changes of congenital hepatic fibrosis, with an essentially normal liver parenchyma divided by broad bands of fibrous tissue containing strikingly dilated abnormal bile ducts.The postoperative course was satisfactory once post-transfusion hepatitis (HBsAg negative) had resolved.
572. rAd-p21 To Reduce Excessive Dermal Scarring: Efficacy, Expression, and Tensile Strength in Animal Models
Authors: David W. Kang, Dan-Ling Gu, L. David Looper, Barry J. Sugarman, Erlinda M. Quijano, Monica L. Zepeda
Journal: Molecular Therapy (2006)

Excessive scarring is a significant clinical problem, resulting in both adverse tissue form and function. We have previously demonstrated that a recombinant adenovirus encoding the cyclin-dependent kinase inhibitor p21 (rAd-p21), attenuated cell proliferation at the wound site (Gu, et al., Wound Rep Reg 2005). In the studies described here, we demonstrate rAd-p21 DNA presence and p21 RNA expression at the wound site for at least 2 weeks in a rabbit ear model of scar formation. Further, we show that 2x106 particles of rAd-p21 reduced scar elevation by 20% in a rabbit ear scar model when compared to treatment with either a vehicle or a control adenovirus not containing a transgene (rAd-Empty). To investigate the potential effect of rAd-p21 on wound strength, we tested wounded tissue treated with rAd-p21 in vivo using tensile strength as an endpoint. Included in the experimental rat model were comparisons with other clinically relevant antiproliferative agents. Specifically, rAd-p21 at doses from 1x107 to 3.8x1010 particles per incision was administered intradermally to linear incisions, and wound strength was assayed 14–28 days post treatment. High doses of rAd-p21 (≥3x1010 particles) resulted in a mild and transient reduction of tensile strength, whereas low to moderate doses (1x107 to 1x1010 particles) had no significant effect on wound strength. Importantly, all rAd-p21 treated wounds regained tensile strength indistinguishable from vehicle treatment within 4 weeks of treatment. High dose rAd-Empty showed a subtle reduction in tensile strength that was only statistically significant at day 21. 100uL of triamcinolone at 5mg/mL/wound, 5-FU at 10mg/mL/wound, and low doses of MMC did not significantly reduce tensile strength, although high doses of MMC (0.2mg/mL/wound) severely reduced tensile strength, and wounds failed to heal completely by 28 days. Morphological analysis of all treatment groups revealed necrosis only in animals treated with MMC. These data suggest that rAd- p21 can minimize excessive scar formation in animals with minimal effects on wound strength. Authors are employees or former employees of Schering-Plough.
The Lack of Effect of Oral Doses of Cinchona Alkaloids on the Circulation of Dogs with Renal Hypertension
Authors: INEZ GREENE, EDWIN P. HIATT
Journal: Circulation (1951)

The effect of repeated oral doses of quinine and quinidine on the circulation of dogs with renal hypertension was studied with measurements of arterial blood pressure and renal hemodynamics. Alkaloid concentrations up to the toxic range had little effect on the blood pressure or renal blood flow. It is pointed out that this lack of effect is in contrast to the vasodilator action of these agents in normal and neurogenic hypertensive dogs. These experiments are interpreted as constituting support for the thesis that the cinchona alkaloids have their vasodepressor effect by virtue of a blockade of sympathetic neuromuscular vasomotor junctions.
Uterine rupture after intra-amniotic injection of prostaglandin E2.
Authors: S Emery, G J Jarvis, D A Johnson
Journal: BMJ (1979)

<h3>Background</h3> Morphea is a form of localized scleroderma characterized from the presence of sclerotic plates localized in the skin. It may be in the form of plaque morphea or generalized. Usually morphea does not associate with systemic involvement, however anti-nuclear antibody (ANA), ds-DNA, etc, are measured in peripherial blood. <h3>Objectives</h3> Idenification of pulmonary involvement in morphea. <h3>Methods</h3> We studied 18 patients diagnosed with morphea. All patient were tested for auto-antibodies: ANA, ENA, Scl-70, anti RNP, ANCAp/c, anti-Sm, anticentrome antibudies. The patient underwent chest x-ray, pulmonary function test, HRCT of the lung. <h3>Results</h3> 12 from 18 patient that we studied resulted with plaque morphea (PM) and the other 6 patients with generalized morphea (GM). We found the presence of ANA the titer ≥1/320 in 8 patient (5 patient with GM and 3 patient with PM). The laboratory results for ds-DNA, ANCAp/c, Scl-70, anti-Sm, anticentromer antibody were negative in all patients. The chest x-ray resulted with interstitial involvement of the lungs of the reticular pattern in 7 patient (5 patient with GM and positive ANA and 2 patient with PM). HRCT in this patients showed the presence of interstitial infiltrate, while pulmonary function test resulted with mild to moderate restrictive syndrome. <h3>Conclusions</h3> Pulmonary involvement is found more frequently in the generalized form of morphea. The patient that resulted positive for ANA have a higher risk for developing pulmonary involvement. Anyway the pulmonary involvement in morphea is moderate. <h3>Disclosure of Interest</h3> None declared
A Case of Abnormal Sexual Development in a Male.
Authors: Chas. E. Woodruff
Journal: JAMA (1889)

An article on "Teratology" inThe Journalof October 20, by Dr. Joseph Jones, of Lousiana, describes the case of John H. Allen, whose sexual organs were so abnormally developed as to make it uncertain whether testicles were present at all. Some of the peculiarities there mentioned are present in the following case, and taken together the two are interesting. The case is that of a Scandinavian, who, in the early part of 1887, attempted to enlist in the U. S. Navy as a seaman. When he undressed for the physical examination, which the writer conducted, the following facts were noted: He was apparently 24 years old, 5 feet 8 inches in height, weighed about 160 pounds, with a chest measurement of about 37 inches, and was of blonde type and in apparent perfect health. Though he possessed considerable strength, his limbs were not muscular in appearance but were excessively
1031-38 Beneficial Effects of Ramipril in a Model of Isoproterenol-induced Heart Failure in the Rat
Authors: Daniela G. Grimm, Dietmar Elsner, Günter Bruckschlegel, Christl Peter, Stephan Holmer, Günter A. Riegger, Eckhard P. Kromer
Journal: Journal of the American College of Cardiology (1995)
NONDEMENTING PSYCHOSES IN OLDER PERSONS
Authors: John J. Madden
Journal: JAMA (1952)

During the past several years, and after a long period of institutional isolation, psychiatry has become well established in the field of private practice. Facilities for such practice in general hospitals are widespread throughout the country and have increased public demand for psychiatric care on the same terms as care provided in physical illness. This has undoubtedly brought about certain reorientations causing physicians to adopt a more optimistic attitude toward both treatment and prognosis in many patients hitherto regarded as unfavorable candidates for intensive, short-term therapy. In the setting of a general hospital the psychiatrist often finds himself the center of strong pressures exerted by the referring physician and relatives to treat an older patient for whom he may offer only the most guarded prognosis. Under these circumstances we have had under our care in the psychiatric unit of a general hospital a series of 300 patients over the age
Emerging technologies should be formally evaluated
Authors: J. Wise
Journal: BMJ (2010)

The UK government needs to urgently establish a risk analysis framework for emerging medical technologies, reports the centre right think tank 2020health.

Their report examines some of the new medical technologies that are likely to have applications within the next 15 years. It particularly focuses on four areas—IT implants, neurotherapeutics, synthetic biology, and genetic prediction.

The report, which was commissioned by the Conservative party, carries out a strengths and weakness (SWOT) analysis to examine the risks and benefits of these technologies. It states that although each of these technologies offers the possibility of therapeutic advances each one also has potential risks.

For example, neural implants have several emerging applications such as managing tremors in Parkinson’s disease or the …
Non-steroidal anti-inflammatory drug-induced jejunal and colonic diaphragm disease: a report of two cases.
Authors: I W Fellows, J M Clarke, P F Roberts
Journal: Gut (1992)

Two patients with intestinal submucosal diaphragm disease associated with non-steroidal anti-inflammatory drugs are presented. The jejunum was affected in one, and in the other the ascending colon. Most previously reported cases have shown ileal disease and no case to date has shown involvement of the colon. The reasons for the localisation of these diaphragms remain unclear.
We’re Not Leaving: 9/11 Responders Tell Their Stories of Courage, Sacrifice, and Renewal
Authors: Jerome Groopman
Journal: JAMA (2011)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Glucagon-Like Peptide-1 (GLP-1) limits myocardial stunning following acute coronary occlusion and reperfusion in conscious canines
Authors: Lazaros A. Nikolaidis, Teresa Hentosz, Aaron Doverspike, Rhonda Huerbin, Lee Zourelias, Carol Stolarski, Daruish Elahl, Richard P. Shannon
Journal: Journal of the American College of Cardiology (2002)
Incident in Haiti
Authors: Jeffrey W. Gaver
Journal: JAMA (1986)

I saw her standing in line one afternoon in the hot Haitian sun, a young woman, perhaps 18 or 19 years old, with an infant cradled in her arms. Her tiny child was bundled up in many layers of clothes and a kerchief despite the searing heat, a custom the Haitians believe helps in fontanelle closure. This woman, along with several hundred other villagers, was patiently waiting in long lines to be seen by the American doctors and other health professionals who were staffing a local clinic for two weeks. Many people had walked for miles to seek medical attention, and some of the sicker people had been transported to the clinic by burro or dugout canoe. The numbers of people were almost endless and, as the clinic closed each day, the line was already formed with the next day's patients, who would wait through the night. Often the staff
Patterns of virus-immune T-cell responsiveness. Comparison of (H-2(k) x H-2(b)) {arrow} H-2(b) Radiation Chimeras and negatively selected H-2(b) lymphocytes
Authors: PC Doherty, Bennink JR
Journal: The Journal of Experimental Medicine (1979)

Negatively selected H-2K(b)D(b) TDL can be induced to respond strongly to vaccinia virus presented in the context of both H-2K(k) and H-2D(b) when stimulated in irradiated H-2K(k)D(b) recipients. Addition of excess (H- 2K(k)D(b) x H-2K(b)D(b))F1 TDL, which are low responders to H-2D(b)-vaccinia virus, does not obviously suppress the reactivity pattern of the H-2K(b)D(b) T cells. However, lymphocytes from chimeras made by reconstituting H- 2K(b)D(b) mice with (H-2K(k)D(k) × H-2K(b)D(b))F(l) bone marrow cells make little, if any, cytotoxic T-cell response to vaccinia virus when sensitized in H-2K(k)D(b) recipients. We have thus documented one instance where the responder phenotype of T ceils from an F(l) {arrow} parent chimera is not equivalent to that associated with the H-2 type of the parental thymus. Lymphocytes from both the chimera and the H-2K(b)D(b) parent (after negative selection) are tolerant to the H-2K(k) and I-A(k) alloantigens encountered in the recipient, but the chimera T cells are also defective in their response to a neoantigen (vaccinia virus) presented in the context of H-2K(k) which the parental T cells invariably recognize. It is thus possible that at least part of the phenomenology associated with the F(l) {arrow} parent radiation chimeras reflects deletion of repertoire in the context of H-2 antigens present during thymocyte ontogeny on other than radiation-resistant thymic epithelium.
Rationality cut off in mobile phone row
Authors: S. Chapman
Journal: BMJ (1995)

Infertility clinics show variation in successA wide variation in the success rates of infer- tility clinics in Britain has been shown by the first patient's guide to services, published by the Human Fertilisation and Embryology Authority (HFEA) last week.Most centres cluster around the national average of a 14% live birth rate for each cycle of in vitro fertil- isation treatment, which is an increase of 1.5% over the last recorded rate.But St James's Hospital in Leeds is the most suc- cessful, with a rate of 23%, while the BUPA Hospital in Norwich had no live births in 1993-4.St James's Hospital treated 374 patients during this time, compared with the BUPA Hospital's 22 patients."Larger centres have a longer duration of experience and have a higher volume opera- tion," said Allan Templeton, professor of obstetrics and gynaecology at the University of Aberdeen and a member of the authority."With breast cancer, if you go to the best centre you get the best treatment, and a similar picture is emerging with in vitro fertilisa- tion, although in another way it's very different."The guide gives adjusted live birth rates, which take into account such factors as the age of the woman, previous unsuccessful cycles of treatment, the presence of male infertility, and whether the couple have had previous children.Ruth Deech, the chair- woman of the authority, said that the birth rate was not the only or even the main rea- son for a couple to choose an infertility clinic.The clinic's atmosphere, distance from the couple's home, and cost were also important factors.The cost of in vitro fertilisation ranges from £700 to £25 000."We are providing national data here which is consistent and comparable," said Ms Deech."We are giving people who are entering an unknown area information enabling them to ask intelligent questions."Ms Deech said that it was not the job of the authority to chivvy clinics that had lower success rates."Our job is to inspect and reg- ulate clinics.to make sure they are behaving properly.Each clinic is inspected every year and cannot operate without a licence.It is not for us to take responsibility for clinics producing higher and higher outcomes.Medicine is not an exact science, and the rates of a clinic can vary from year to year."Diana Brittan, deputy chairwoman of the authority, said that it was extraordinary to expect infertility treatment to have any guar- antees."Even with the best medical care you may not end up having a baby," she said."penn meets egg
The Management of the Complications of Peptic Ulcer
Authors: T. Grier Miller
Journal: New England Journal of Medicine (1941)

THE important complications of peptic ulcer are perforation, hemorrhage, cicatricial stenosis and, in gastric ulcer, malignant degeneration. Their management, in a broad sense, involves not only procedures designed to restore their victims to good health but also measures to prevent their development. This necessitates, in the first place, a brief consideration of the treatment of simple uncomplicated peptic ulcer. Although perforation or hemorrhage occasionally represents the first manifestation of peptic ulcer, it is exceedingly uncommon for either of them to develop in a person on an adequate ulcer program; this is not necessarily true for obstruction
A Structured Teaching and Self-management Program for Patients Receiving Oral Anticoagulation&lt;SUBTITLE&gt;A Randomized Controlled Trial&lt;/SUBTITLE&gt;
Authors: Peter T. Sawicki
Journal: JAMA (1999)

Control of oral anticoagulation therapy has been reported to often be inadequate. Previous retrospective investigations suggest that patients' self-adjustment of oral anticoagulants may lead to improved control.To investigate the effects of patients' self-management of oral anticoagulation therapy on accuracy of control and measures of treatment-related quality of life.Randomized, single-blind, multicenter trial.A total of 179 patients receiving long-term oral anticoagulation treatment were enrolled at 5 referral centers in Germany.Patients were randomized to an oral anticoagulation self-management group based on a structured treatment and teaching program and international normalized ratio (INR) self-monitoring. The control group received conventional care as provided by family physicians, including referral to specialists if necessary.Deviation of INR values from the individual INR target range (squared) and the 5 categories of treatment-related quality of life.Deviation of INR value from the mean of the INR target range was significantly lower in the intervention group at 3-month (squared INR deviation, 0.59 vs 0.95; P<.001) and 6-month follow-up (0.65 vs 0.83; P=.03) compared with the control group. Also, the intervention group had INR values within the target range more often (repeated measurement analysis for categorical data, P=.006). The results were mainly due to less frequent suboptimal INR values in the intervention group (32.8% vs 50.0% [P=.03] at 3-month, and 33.7% vs 48.2% [P=.08] at 6-month follow-up). Treatment-related quality-of-life measures, especially treatment satisfaction scores, were significantly higher in the intervention group compared with controls.An anticoagulation education program that includes self-management of anticoagulation therapy results in improved accuracy of anticoagulation control and in treatment-related quality-of-life measures. Further studies are needed to describe whether the program will reduce risk of bleeding or thromboembolism.
TCT-493 The Clinical Utility of High-Sensitive Troponin T to Predict Infarct Size, Left Ventricular Function and Adverse Outcome in Patients with First ST Elevation Myocardial Infarction Treated with Primary Percutaneous Coronary Intervention
Authors: H. Boden, T.A.N. Ahmed, M.A. Velders, B.L. van der Hoeven, G.E. Hoogslag, M. Bootsma, S. le Cessie, C.M. Cobbaert, A. van der Laarse, M.J. Schalij
Journal: Journal of the American College of Cardiology (2012)
Effect of Escherichia coli enterotoxins on macromolecular absorption.
Authors: M Verma, S Majumdar, N K Ganguly, B N Walia
Journal: Gut (1994)

Macromolecular absorption of gliadin, a wheat protein and alpha lactalbumin, a milk protein was evaluated in control and Escherichia coli enterotoxin (heat-stable, heat-labile, and both heat-stable and heat-labile enterotoxin) treated mice. The peak concentration of gliadin and lactalbumin was two hours and three hours after their ingestion, respectively. There was also a significant increase (p &lt; 0.01) in the absorption of both the proteins in all the three toxin treated groups compared with the control group. These results suggest that intestinal permeability and macromolecular absorption changes after E coli infection.