tbuckley/cabot-search huggingface dataset:
Abstract 2958: Knockdown of Src expression dissolves resistance to TRAIL-induced apoptosis in oral cancer cells.
Authors: Tomohiro Hamakawa, Satoshi Hino, Koh-ichi Nakashiro, Hiroyuki Hamakawa
Journal: Cancer Research (2013)

Abstract A radical operation for advanced oral cancer results in malfunction of chewing, swallowing, and pronouncing etc. Nevertheless, the most standard therapy for oral cancer is a surgical resection because of its good outcome compared to radiation and chemotherapy. It is expected that treatment is less-invasive and effective against not only primary lesion but also metastatic sites or cells with metastatic potential. Because the acquisition of resistance to anoikis and apoptosis is considered as an essential event to successfully metastasize, we focused on the apoptotic signaling pathways mediated by natural death ligands. In this study, we have used oral squamous cell carcinoma (OSCC) cell lines with distinct metastatic potential and attempted to disclose their apoptosis sensitivity. More than half of the cells died under the low attachment culture condition in all OSCC cell lines with no relation between their metastatic potential, while other kind of cancer cell lines showed anoikis resistance. SAS cells established from human tongue squamous cell carcinoma showed modest sensitivity to tumor necrosis factor-related apoptosis-inducing ligand (TRAIL), whereas SAS-T5 and SAS-L1 cells, a clone with high metastatic potential showed robust resistance. Fas ligand (Anti-Fas/CD95 monoclonal antibody) showed the similar trend of apoptosis induction as well as TRAIL, but TNF-α had no effect in these cells. We confirmed that the expression levels and the localization of TRAIL receptors were not correlated with TRAIL sensitivity. One of the mechanisms underlying the differences in resistance between these cell lines was an activity of Src kinase. Phosphorylated Src (Tyr 416), the active form, was upregulated in SAS-T5 and SAS-L1 cells compared to parental SAS cells. Src inhibitor PP2 suppressed cell proliferation in response to dependence on Src signaling. Downregulation of Src with siRNA made metastatic cells dissolve the resistance to TRAIL-induced apoptosis. These results suggest that combination therapy with TRAIL plus medicine inhibiting Src kinase may be a treatment strategy for oral squamous cell carcinoma. Citation Format: Tomohiro Hamakawa, Satoshi Hino, Koh-ichi Nakashiro, Hiroyuki Hamakawa. Knockdown of Src expression dissolves resistance to TRAIL-induced apoptosis in oral cancer cells. [abstract]. In: Proceedings of the 104th Annual Meeting of the American Association for Cancer Research; 2013 Apr 6-10; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2013;73(8 Suppl):Abstract nr 2958. doi:10.1158/1538-7445.AM2013-2958
Biophysical Mechanisms in Vascular Homeostasis and Intravascular Thrombosis
Authors: Robert T. Breckenridge
Journal: JAMA (1965)

ABSTRACT Since the time of Virchow it has been postulated that a change in the chemistry of the endothelium lining blood vessels is one of the primary events in the initiation of thrombosis. It is well-known that negatively charged surfaces, such as glass, are clot-promoting in vitro as a direct result of their ability to activate Hageman factor (Factor XII). The problem has been, whether Hageman factor must be activated in vivo for thrombosis to occur and, if so, what kind of a biochemical and biophysical process takes place at the endothelial surface to initiate the coagulation.There have been two methods of approach to this problem. The first is that of the coagulationist who examines the result of treating coagulation proteins with various surfaces in vitro. The second is that of the investigator who measures the biophysical counterparts of normal blood flow and thrombus formation. This monograph is the written
Placebo-Control Evaluation of Desipramine in Depression
Authors: ANTHONY LAPOLLA, HARRY JONES
Journal: American Journal of Psychiatry (1970)

A double-blind clinical trial was conducted to compare the effectiveness of desipramine and placebo in newly hospitalized patients. Analysis of data from 74 patients (34 on desipramine, 40 on placebo) showed that in patients with endogenous depression, the response to desipramine was superior to response to placebo as early as the fifth day of treatment; in patients with neurotic (reactive) depression, no significant differences in response were found.
Immunological Investigation of Possible Structural Similarities between Pollen Antigens and Antigens in Apple, Carrot and Celery Tuber
Authors: L. Halmepuro, H. Løswenstein
Journal: Allergy (1985)

Crossed line immunoelectrophoresis (CLIE) was used to show that a minor allergen present in birch pollen and another present in timothy pollen shared common epitopes with antigens in apple, carrot and celery tuber. Major pollen allergens were not involved. Structural similarities were also noticed in some mugwort pollen antigens and antigens in apple, carrot and celery, but none of these mugwort antigens acted as an allergen. In crossed immunoelectrophoresis (CIE) of samples of apple, carrot or celery extracts towards antibodies against birch pollen, grass pollen or mugwort pollen, four to 14 distinct precipitates were observed and shown to be specific. In crossed radioimmunoelectrophoresis (CRIE) none of the precipitates could be shown to act as an allergen. Using allergen detection on nitrocellulose paper, the apple, carrot and celery extracts were shown to possess IgE‐binding capacity.
Serum ferritin concentration and oral iron treatment in patients on regular haemodialysis.
Authors: A M Cotterill, J N Flather, W R Cattell, M D Barnett, L R Baker
Journal: BMJ (1979)

Two patients with schizophrenic-like psychosis after treatment with beta-adrenergic blockersWe have recently seen two patients suffering from psychotic illnesses which developed during treatment with 3-adrenergic-blocking drugs that had been prescribed for cardiovascular illnesses. Case 1This 53-year-old woman's sister, son, and cousin suffered from schizo- phrenia.She had no psychiatric history, although she had always been
Phospholemman, a chaperone of Na,K-ATPase?
Authors: P FRANSEN
Journal: Cardiovascular Research (2004)

See article by Silverman et al.  [8]  (pages 93–103) in this issue .

Control of intracellular Na+ homeostasis is of crucial importance for normal functioning of the heart. Na+ extrusion in cardiomyocytes occurs mainly via the sodium pump or Na+,K+-ATPase. This enzyme consists of a catalytic α-subunit with binding sites for ATP, Na+, K+ and cardiac glycosides, and a glycoprotein β-subunit. The main function of this pump in cardiac myocytes is to maintain and restore ion gradients for Na+ and K+ during electrical activity by mediating active transport of 3Na+ out and 2K+ into the cell. Of the four α-isoforms, α1, α2 and α3 have been described in cardiac tissue, where they have multiple functions and a different localization in the different cell types or even within a single cardiomyocyte. The isoforms display variable sensitivity to inhibition by cardiac glycosides; the α1 isoform, for example, is less sensitive to ouabain than the α2 or α3 isoform [1–5].

The activity of the Na+,K+-ATPase is sensitive to changing cellular conditions and to physiological stimuli. As a consequence, other Na+-dependent membrane transporters such as the Na+/Ca2+ exchanger, the Na+/H+ exchanger and the Na+/HCO3− transporter, and, hence, cellular Ca2+ and pH homeostasis, are dependent on Na+/K+-ATPase activity [6]. Most of the hormones … 

*Tel.: +32 3 820 25 87; fax: +32 3 820 25 67. Email address: paul.fransen{at}ua.ac.be
Case-control study of hepatitis B and hepatitis C in older adults: Do healthcare exposures contribute to burden of new infections?
Authors: Joseph F. Perz, Scott Grytdal, Suzanne Beck, Ana Maria Fireteanu, Tasha Poissant, Elena Rizzo, Katherine Bornschlegel, Ann Thomas, Sharon Balter, Jeremy Miller, Monina R. Klevens, Lyn Finelli
Journal: Hepatology (2012)

Reports of hepatitis B virus (HBV) and hepatitis C virus (HCV) transmission associated with unsafe medical practices have been increasing in the United States. However, the contribution of healthcare exposures to the burden of new infections is poorly understood outside of recognized outbreaks. We conducted a case-control study at three health departments that perform enhanced viral hepatitis surveillance in New York and Oregon. Reported cases of symptomatic acute hepatitis B and hepatitis C occurring in persons≥55 years of age from 2006 to 2008 were enrolled. Controls were identified using telephone directories and matched to individual cases by age group (55-59, 60-69, and ≥70 years) and residential postal code. Data collection covered exposures within 6 months before symptom onset (cases) or date of interview (controls). Forty-eight (37 hepatitis B and 11 hepatitis C) case and 159 control patients were enrolled. Case patients were more likely than controls to report one or more behavioral risk exposures, including sexual or household contact with an HBV or HCV patient, >1 sex partner, illicit drug use, or incarceration (21% of cases versus 4% of controls exposed; matched odds ratio [mOR]=7.1; 95% confidence interval [CI]: 2.1, 24.1). Case patients were more likely than controls to report hemodialysis (8% of cases; mOR=13.0; 95% CI: 1.5, 115), injections in a healthcare setting (58%; mOR=2.7; 95% CI: 1.3, 5.3), and surgery (33%; mOR=2.3; 95% CI: 1.1, 4.7). In a multivariate model, behavioral risks (adjusted OR [aOR]=5.4; 95% CI: 1.5, 19.0; 17% attributable risk), injections (aOR=2.7; 95% CI: 1.3, 5.8; 37% attributable risk), and hemodialysis (aOR=11.5; 95% CI: 1.2, 107; 8% attributable risk) were associated with case status.Healthcare exposures may represent an important source of new HBV and HCV infections among older adults.
Comparison of Coronary Artery Bypass Surgery and Medical Therapy in Patients 65 Years of Age or Older
Authors: Bernard J. Gersh, Richard A. Kronmal, Hartzell V. Schaff, Robert L. Frye, Thomas J. Ryan, Michael B. Mock, William O. Myers, Marion W. Athearn, Arthur J. Gosselin, George C. Kaiser, Martial G. Bourassa, Thomas Killip
Journal: New England Journal of Medicine (1985)

We compared the results of coronary artery bypass surgery with those of medical therapy alone in 1491 nonrandomized patients 65 years of age or older. Cumulative survival at six years (adjusted for major differences in important base-line characteristics) was 79 per cent in the surgical group and 64 per cent in the medical group (P<0.0001). At five years, chest pain was absent in 62 per cent of the surgical group and 29 per cent of the medical group (P<0.0001). Analysis by the Cox proportional-hazards model suggested an independent beneficial effect of surgery on survival (P<0.0001). Patients were divided into risk quartiles on the basis of preoperative predictors of survival identified by the Cox model. Surgical benefit was greatest in "high-risk" patients (those in the two quartiles containing patients with the poorest prognosis). Among 234 "low-risk" patients with mild angina, relatively good ventricular function, and no left main coronary artery disease, there was no survival difference between those treated medically and those treated surgically. We conclude that in specific higher-risk subsets of nonrandomized patients 65 years of age or older, coronary bypass surgery appeared to improve survival and symptoms in comparison with medical therapy alone. These conclusions must be tempered by consideration of the limitations of nonrandomized studies, particularly since patients in the two treatment groups differed substantially with regard to important base-line characteristics. (N Engl J Med 1985;313:217–24).
Modified Kondoleon Operation for Elephantoid Legs
Authors: T. Kanakaraju
Journal: New England Journal of Medicine (1954)

ELEPHANTIASIS of the legs is a crippling disability, attempts at the surgical correction of which are often unsatisfactory. This paper, which is based on work done by me and my associates in Rajahmundry, in South India, describes an operation that may be of interest to surgeons in other parts of the world. The procedure, with the modifications indicated, does not require too much time and is not followed by complications. Skin grafts take well, and healing occurs in a surprisingly short time; patients are afebrile throughout the postoperative period.TechnicIn 1874 Sappey observed that the deep fascia forms an . . .
The Analysis of a Case of Frigidity (Psychopathology–Psychodynamics)
Authors: G.S. Philippopoulos
Journal: Psychotherapy and Psychosomatics (1967)

Research Articles| February 12 2010 The Analysis of a Case of Frigidity (Psychopathology–Psychodynamics) Subject Area: Psychiatry and Psychology G.S. Philippopoulos G.S. Philippopoulos Athens University Medical School, Department of Psychiatry, Athens, Greece Search for other works by this author on: This Site PubMed Google Scholar Psychother Psychosom (1967) 15 (2-4): 220–230. https://doi.org/10.1159/000285892 Article history Published Online: February 12 2010 Content Tools Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Facebook Twitter LinkedIn Email Tools Icon Tools Get Permissions Cite Icon Cite Search Site Citation G.S. Philippopoulos; The Analysis of a Case of Frigidity (Psychopathology–Psychodynamics). Psychother Psychosom 31 December 1967; 15 (2-4): 220–230. https://doi.org/10.1159/000285892 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAll JournalsPsychotherapy and Psychosomatics Search Advanced Search Article PDF first page preview Close Modal 1967Copyright / Drug Dosage / DisclaimerCopyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher.Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. You do not currently have access to this content.
RUPTURE OF VEIN OF DERMOID CYST: Intraperitoneal Haemorrhage: Operation: Recovery
Authors: J. O. Beven
Journal: BMJ (1920)

AUG. T4, r9201 r~_MEDICAL JOURNAL__4seen recorded in the tracina.Two injections of adrenalin were given; the effect of eaclh was to increase the volume Df air entering the lung as tlle result of dilatation of the .A_4;, -'S-."--bronchioles and to cause a rise of blood pressure.The effects were temporary.The third injection was atropine, wlichl produced permanent and maximal broncho-dilatation by paralysing the bronclio-constrictor nerves, and increased cardiac rate, and therefore blood pressure, by paralysing the cardiac vagus.
Synergy of abciximab and ticiopidine in patients undergoing intracoronary stenting
Authors: N.S. Kleiman, N. Graziadei, E. Lance, K. Maresh, J. Taylor, J. Higginbotham, A. Edwards, M.B. Effron, M.A. Mascalli, R.E. Jordan
Journal: Journal of the American College of Cardiology (1998)
Adrenocorticosteroids in the Treatment of Tuberculosis
Authors: Haskell J. Weinstein, John J. Koler
Journal: New England Journal of Medicine (1959)

THE empirical use of corticosteroids as an adjuvant in the treatment of pulmonary tuberculosis has received widespread attention as well as a degree of acceptance.1 2 3 4 5 6 7 8 Beginning in 1954, under the direction of the late Dr. Daniel W. Zahn, medical director, a roster was maintained at Firland Sanatorium of patients being treated for active pulmonary tuberculosis, who also received corticosteroids for associated pathologic processes. By 1956, 83 patients on this roster had been treated with both tuberculous chemotherapy and steroids for tuberculous meningitis, drug sensitivities, adrenal depletion, collagen disease and acute toxic states. The courses suggested that, with adequate antituberculous chemotherapy, . . .
THYMUS-INDEPENDENT (B) CELL PROLIFERATION IN SPLEEN CELL CULTURES OF MOUSE RADIATION CHIMERAS STIMULATED BY PHYTOHEMAGGLUTININ OR ALLOGENEIC CELLS
Authors: P.-F. Piguet, P. Vassalli
Journal: The Journal of Experimental Medicine (1972)

Spleen cell cultures of radiation chimeras (thymectomized, lethally irradiated mice repopulated with bone marrow cells and thymocytes bearing different chromosomal markers) were stimulated by phytohemagglutinin (PHA) and F(1) allogeneic spleen cells. Karyotypic analyses showed a marked predominance of T mitoses on the 2nd and 3rd days of culture followed by a strong predominance of B mitoses on the 4th and 5th days. Analysis of cells undergoing their first mitoses showed that the majority of T mitoses on day 3 resulted from continuous T cell division, and that most cells entering their first mitoses at that time were of B type. Mixed lymphocyte cultures (MLC) of chimeras immunized against allogeneic spleen cells showed sometimes, but not always, a response different from "primary" MLC, with an earlier and stronger predominance of BM mitoses. The role of stimulated T cells in the induction of B mitoses was shown by (a) the incapacity of T-depleted spleen cells to be stimulated by PHA or in primary or secondary MLC, and (b) the restoration of the mitotic response of B cells to PHA by adding to the T cell-depleted culture either a very small number of T cell (identified by their different karyotype: "in vitro chimeras") or the cell-free supernatant of a 24 hr MLC.
Titanium Dioxide Nanoparticles Induce DNA Damage and Genetic Instability <i>In vivo</i> in Mice
Authors: Benedicte Trouiller, Ramune Reliene, Aya Westbrook, Parrisa Solaimani, Robert H. Schiestl
Journal: Cancer Research (2009)

Abstract Titanium dioxide (TiO2) nanoparticles are manufactured worldwide in large quantities for use in a wide range of applications including pigment and cosmetic manufacturing. Although TiO2 is chemically inert, TiO2 nanoparticles can cause negative health effects, such as respiratory tract cancer in rats. However, the mechanisms involved in TiO2-induced genotoxicity and carcinogenicity have not been clearly defined and are poorly studied in vivo. The present study investigates TiO2 nanoparticles–induced genotoxicity, oxidative DNA damage, and inflammation in a mice model. We treated wild-type mice with TiO2 nanoparticles in drinking water and determined the extent of DNA damage using the comet assay, the micronuclei assay, and the γ-H2AX immunostaining assay and by measuring 8-hydroxy-2′-deoxyguanosine levels and, as a genetic instability endpoint, DNA deletions. We also determined mRNA levels of inflammatory cytokines in the peripheral blood. Our results show that TiO2 nanoparticles induced 8-hydroxy-2′-deoxyguanosine, γ-H2AX foci, micronuclei, and DNA deletions. The formation of γ-H2AX foci, indicative of DNA double-strand breaks, was the most sensitive parameter. Inflammation was also present as characterized by a moderate inflammatory response. Together, these results describe the first comprehensive study of TiO2 nanoparticles–induced genotoxicity in vivo in mice possibly caused by a secondary genotoxic mechanism associated with inflammation and/or oxidative stress. Given the growing use of TiO2 nanoparticles, these findings raise concern about potential health hazards associated with TiO2 nanoparticles exposure. [Cancer Res 2009;69(22):8784–9]
Pacing the Human Cardiac Conduction System During Open-heart Surgery
Authors: JOEL KUPERSMITH, EHUD KRONGRAD, FREDERICK O. BOWMAN, JAMES R. MALM, ALBERT L. WALDO
Journal: Circulation (1974)

Specialized fiber electrograms were recorded from selected sites along the His bundle and bundle branches during open-heart surgery in 26 patients. The heart was then paced from the same recording sites. Stimuli applied to the proximal His bundle recording site always resulted in His bundle pacing, which was characterized by a stimulus artifact-to-QRS interval which equaled or very nearly equaled the previously recorded His bundle electrogram-to-QRS interval, and no change in QRS duration or waveform from that recorded with a conducted atrial beat. When stimuli were applied to distal His bundle recording sites, the response was variable: in some instances, ventricular pacing occurred; in other instances, His bundle pacing occurred; and in still other instances, ventricular pacing occurred when high stimulus amplitudes were applied, while His bundle pacing occurred when the stimulus amplitudes were reduced below a range of 0.5-3.5 ma. Stimuli applied to the right or left bundle branch recording sites always resulted in ventricular pacing. Therefore, when stimuli are applied to specialized fiber recording sites and His bundle pacing results, it is certain that the site of origin of the previously recorded specialized fiber electrogram is the His bundle, but when ventricular pacing results, the site of origin of the previously recorded specialized fiber electrogram could be the distal His bundle or the bundle branches.
884. Anti-Oxidant Gene Delivery to Retinal Epithelial Cells: A Gene Therapy Approach for Macular Degeneration
Authors: Lisa McGinley, Gillian Cosgrave, Aoife Duffy, Timothy O'Brien, Padraig M. Strappe
Journal: Molecular Therapy (2006)

Age related macular degeneration (AMD) is a progressive degenerative disorder that affects the retina, retinal pigments and the choriocapillaries of the eye. Oxidative stress has been implicated in AMD through the production of reactive oxygen species (ROS) in the retinal pigment epithelium (RPE), which provides structural and nutritional support to the retina. Blue light exposure, elevated oxygen tension and high cellular lipid content contribute to oxidative stress in the RPE.