tbuckley/cabot-search huggingface dataset:
Abstract 127: Comparison of Vital Sign Abnormalities Prior to Ward Cardiac Arrest vs Intensive Care Unit Transfer
Authors: Matthew M Churpek, Trevor C Yuen, Seo Young Park, Dana P Edelson
Journal: Circulation (2011)

INTRODUCTION:  Previous studies have demonstrated that most patients who suffer cardiac arrest (CA) on the ward have abnormal vital signs prior to the event. However, no study to date has compared the vital signs of CA patients to patients transferred to the intensive care unit (ICU).   METHODS:  All adult patients hospitalized at an academic institution from November 2008 to January 2011 were included in this retrospective study. Vital signs for each patient documented on the ward from admission until a first CA, first ICU transfer, or hospital discharge (controls) were extracted from an electronic medical record (EPIC, Verona, WI). The mean maximum and minimum values for each vital sign were compared between groups using t-tests. Area under the receiver operating characteristic curve (AUC) was also calculated for each vital sign by comparing the CA and ICU transfer groups to controls.   RESULTS:  A total of 47427 patients were included in the study (2820 ICU transfers, 88 CA patients, and 44519 controls). Compared to ICU transfer patients, CA patients had a higher mean maximum heart rate and a lower mean minimum diastolic blood pressure and temperature (Table). The best predictors of CA were maximum respiratory rate (AUC 0.76), maximum heart rate (AUC 0.69), and minimum diastolic blood pressure (AUC 0.63). For ICU transfer, the best predictors were maximum respiratory rate (AUC 0.66), maximum heart rate (AUC 0.61), minimum oxygen saturation (AUC 0.58), and minimum systolic blood pressure (AUC 0.55).   CONCLUSIONS:  Patients transferred to the ICU and those suffering CA both have significant vital sign abnormalities. Although the abnormalities are more severe in CA patients, they are not transferred to a higher-level of care. Further work into deriving a CA risk prediction model may assist in identifying these critically ill patients.
Abstract 288: Nox1 is Required for Smooth Muscle Cell Activation of Matrix-Metalloproteinase-9 and Cell Migration in Response to Thrombin
Authors: Jagadeesha K Dammanahalli, Botond Banfi, Ramesh C Bhalla, Francis J Miller
Journal: Circulation (2006)

Smooth muscle cell (SMC) degradation of the extracellular matrix and migration to the intima are fundamental processes in the vascular response to injury. NADPH oxidase-derived reactive oxygen species (ROS) are involved in development of vascular disease, however, the specific contribution of Nox1 and Nox4, the primary catalytic subunits of NADPH oxidase in SMC, is poorly understood. We hypothesized that Nox1-derived ROS mediate thrombin-dependent activation of matrix-metalloproteinase-9 (MMP-9) and migration of SMC. Studies were performed in SMC cultured from the aorta of Nox1 null and littermate control mice. Thrombin (2 U/ml) increased superoxide levels in control SMC, as measured by dihydroethidium, and this response was inhibited by the flavoenzyme inhibitor diphenylene iodonium (DPI, 10 μM). In contrast, thrombin failed to increase ROS in Nox1 null SMC. Previous studies have identified Src and mitogen activated protein kinases as key redox-dependent regulatory proteins in thrombin stimulated responses. Five minutes following thrombin stimulation, both Src and ERK1/2 phosphorylation were significantly decreased in Nox1 null SMC as compared to normal SMC (0.5±0.1 vs. 2.0 ± 0.4 for Src and 0.1 ± 0.1 vs. 2.9 ± 0.1 for ERK1/2, p
Abstract 2496: Eplerenone Attenuates Left Ventricular Remodeling after Acute Myocardial Infarction in Patients with Left Ventricular Systolic Dysfunction
Authors: Robin A Weir, Aengus Murphy, Patrick B Mark, Suzanne Clements, Tracey Steedman, Ian Ford, John J McMurray, Henry J Dargie
Journal: Circulation (2007)

Introduction: Eplerenone reduces morbidity and mortality in patients with left ventricular systolic dysfunction (LVSD) and heart failure (HF) or diabetes, after acute myocardial infarction (AMI). T...
Multiple Mucosal Neuroma
Authors: Marie Rouzaud, Franck Boralevi
Journal: New England Journal of Medicine (2015)

A 9-year-old boy presented with a history of asymptomatic soft, yellow papules measuring 3 to 12 mm on the tip of his tongue, along with chronic constipation and abdominal discomfort since infancy. Findings on histologic analysis of lesion samples were consistent with mucosal neuroma.
Monoclonal antibody KID24 targets human ADAM9 and is a potent inhibitor of tumor growth and metastasis in vivo
Authors: Tony Liang, Francine Chen, Suzanne Coberly, Jonathan Li, Peter Young, Beverly Potts, Monica Licea, Mark Armanini, Yan Chen, Dharmendra Ahluwalia, Claude Beltejar, Darlene Cruz, Deryk Loo
Journal: Cancer Research (2008)

3989  ADAM9, a member of the A Disintegrin And Metalloprotease family of proteins, is a membrane-anchored protein containing an SH3 domain-containing cytoplasmic tail and an extracellular domain comprised of a pro-domain, metalloprotease domain, disintegrin domain, cystein-rich domain, and an epidermal growth factor repeat. ADAM9 has been shown to regulate E-Cadherin internalization and participate in integrin-mediated adhesion processes, and is thought to play a role in tumor aggressiveness. We have developed an ADAM9-specific monoclonal antibody, termed KID24, which is the first reported antibody that inhibits the catalytic activity of ADAM9 in vitro. Immunohistochemical analysis demonstrated KID24 exhibits preferential staining of human tumor tissue over normal tissue. Elevated KID24 staining was observed in lung, colon, pancreatic and prostate adenocarcinomas, confirming previous reports defining ADAM9 as a tumor-associated antigen. ADAM9 is also expressed by a number of Raven cancer stem cell lines derived from solid tissue cancers, including a Merkel cell carcinoma (MCC) cancer stem cell line. Based on the expression pattern of ADAM9 and the inhibitory activity of KID24 toward ADAM9 in vitro, we examined KID24 antitumor activity in vivo using two xenograft models: A549 lung carcinoma and MCC. Treatment of established subcutaneous A549 xenografts with KID24 at 25mg/kg/dose ip twice weekly for 7 weeks led to a 40-60% reduction in tumor size relative to control tumors. Further, KID24 treatment (50 mg/kg/dose twice weekly) of MCC xenografts for three weeks led to a 70% reduction in the size of the primary tumor, relative to control tumors. Most strikingly, KID24 treatment significantly reduced the number and size of spontaneous metastatic lesions in the lung, diaphragm, pancreas, mesentery and spleen in mice bearing MCC xenografts. Because we have not observed direct growth inhibitory or cytotoxic activity with KID24 in cell-based assays, we hypothesize that the in vivo antitumor activity of KID24 may occur through an indirect effect of inhibiting ADAM9 enzymatic activity, or may occur via non-enzymatic mechanisms such as regulation of cell/matrix interactions. As a step toward understanding the antitumor mechanism(s) of the KID24/ADAM9 interaction, we examined possible substrates of ADAM9 that may be modulated by KID24. Of note, we found that processing of the proapoptotic Fas ligand by cultured tumor cells can be modulated by KID24, suggesting that inhibition of ADAM9 catalytic activity may be one mechanism by which KID24 exerts antitumor activity. In summary, KID24 exhibits potent antitumor activity toward primary and metastatic tumors, and the observed activity may result from modulation of multiple ADAM9-mediated mechanisms.
A 25-year-old woman with hallucinations, hypersexuality, nightmares, and a rash [clinical conference]
Authors: S L Stein, H B Solvason, E Biggart, D Spiegel
Journal: American Journal of Psychiatry (1996)

A 25.year-old Asian-American single woman, diagnosed with chronic paranoid schizophrenia since age 19, was referred from the inpatient psychiatric unit for evaluation of atypical hallucinations. She had been admitted 3 days earlier after an intentional overdose of 32 over-the.counter sleeping pills. In the emergency room the patient suffered a witnessed grand mal selzure without incontinence, which was followed by a brief period of confusion and combativeness. A computerized tomogra phy (CT) scan of the brain and an EEG at the referring hospital were reportedly normal. A repeat EEC at our hospital demonstrated intermittent asymmetry with posterior right-hemisphere background slowing, which was considered artifact. The patient expressed a delusional belief that she was controlled by an attractive, popular male former high school teacher who had put a curse on her family before her birth and was now sexually obsessed with her. When her eyes were closed, the patient experienced auditory hallucinations and a single visual hallucination consisting of the man’s face in a black spot that wandered throughout her field of vision. She constantly experienced vivid tactile hallucinations of this man molesting her genitally but not having intercourse with her, and she believed that he videotaped her showering and masturbating in order to show these
Sphinx: A novel mutation that promotes liver tumor growth and impairs cytotoxic lymphocyte development
Authors: Michael Barnes, Bruce Beutler, Kasper Hoebe
Journal: Cancer Research (2007)

3850   The full spectrum of genetic lesions that contribute to liver tumor development remains ill-defined. Using a forward genetic approach, we have identified an  N -ethyl- N -nitrosourea induced germ-line mutation that promotes hepatocarcinogenesis. The mutation, named  Sphinx , acts as a recessive allele. Homozygotes show progressive liver tumor growth at multiple foci and concurrent anemia by five weeks of age. Tumors had the morphology of well differentiated hepatic adenomas and no metastases in other organs were observed. Death occurred in homozygotes at the age of eight to twelve weeks. Severe hematopoietic defects were noted, including lymphopenia in the spleen, lymph nodes and bone marrow. Additionally,  Sphinx  homozygotes lacked cytotoxic lymphocytes in peripheral lymphoid organs, although CD8 +  single positive T cells were present (though reduced) in the thymus and mature natural killer (NK) cells accumulated in the bone marrow. These phenotypes were concordant in 15 of 15 backcrossed and 70 of 70 intercrossed mice, suggesting the complex phenotype derived from a single genetic locus. Positional cloning has mapped the  Sphinx  mutation to a region on Chromosome 6 in which there are no obvious candidate genes for such a phenotype. We expect cloning the causative mutation will reveal a novel gene involved in both tumor progression and lymphocyte development, and will establish a new mouse model to study hepatocarcinogenesis.
Abstract 5694: Interpretation of the Spatial QRS-T Angle: Normal Limits in Healthy Subjects and Implications for Risk Stratification
Authors: Roderick W Scherptong, Ivo R Henkens, Sum Che Man, Saskia Le Cessie, Hubert W Vliegen, Arie C Maan, Martin J Schalij, Cees A Swenne
Journal: Circulation (2008)
Abstract 193: Lapaquistat Acetate, A Novel Squalene Synthase Inhibitor, Co-administered with Atorvastatin Reduces Plasma Lipids and C-Reactive Protein Levels in Subjects with Primary Hypercholesterolemia
Authors: Michael H Davidson, Kevin C Maki, James H Zavoral, Shawn Yu, Clement Popovici, Graham D Price
Journal: Circulation (2007)

Background/Objective: Lapaquistat acetate (LAPA), a novel lipid-lowering agent, inhibits squalene synthase, an enzyme distal to HMG-CoA reductase in the cholesterol biosynthetic pathway. We evaluated the effects of LAPA on LDL-C, other plasma lipid variables, and high-sensitivity C-reactive protein (hs-CRP) levels when co-administered with a stable dose of the HMG-CoA reductase inhibitor, atorvastatin (ATV), in subjects with primary hypercholesterolemia already on ATV therapy. Methods: This multicenter, randomized, double-blind, placebo-controlled, Phase III trial was conducted at 79 centers in the US. After a 4-wk dietary run-in and ATV (10, 20, or 40 mg/d) stabilization, 448 subjects (LDL-C ≥100 mg/dL, TG ≤400 mg/dL) were randomized to 1 of 3 treatments: LAPA 50 mg, 100 mg, or placebo co-administered with ongoing ATV dosed once daily for 24 wks. The primary endpoint was percent (%) change from baseline in direct LDL-C at 24 wks; secondary endpoints included % changes in calculated LDL-C, total cholesterol (TC), non-HDL-C, Apo B, TG, HDL-C, VLDL-C, Apo A1, and hs-CRP levels. Safety was monitored using clinical and laboratory examinations. Results: Baseline clinical and lipid characteristics were comparable among the 3 treatment groups. Compared with placebo, LAPA treatment resulted in significant reductions (see Table ) in LDL-C, other lipid variables, and hs-CRP. The enhanced LDL-C-lowering effect was independent of ATV dose. LAPA co-administration was well tolerated. Overall, adverse event (AE) incidences were similar in the 3 treatment groups. Serious AEs in 12 subjects (5 in placebo, 3 in 50 mg LAPA, and 4 in 100 mg LAPA) were reported. Conclusion: Lapaquistat acetate, a novel squalene synthase inhibitor, was well tolerated and effective in reducing LDL-C, hs-CRP, and in improving the atherogenic lipid profile when co-administered with atorvastatin. This combination may prove to be a useful therapeutic option for patients with hypercholesterolemia. Least Squares Mean % Change from Baseline (±SE)
Familial transmission of schizotypal and borderline personality disorders
Authors: Miron Baron, Rhoda Gruen, Lauren Asnis, Sally Lord
Journal: American Journal of Psychiatry (1985)

The authors determined the risk for psychiatric disorders in the first-degree relatives of 36 probands with schizotypal personality disorder (13 definite, 23 probable), 17 probands with borderline personality disorder (two definite, 15 probable), and 90 normal control probands. The relatives of probands with schizotypal personality disorder without a concurrent diagnosis of borderline personality disorder had a significantly greater risk for schizotypal personality disorder than the relatives of normal control probands, borderline probands, or schizotypal probands with coexisting borderline personality disorder. The relatives of borderline probands had a significantly greater risk for definite and probable borderline personality disorder than the relatives of normal control probands.
Abstract 1515: Regional Effects of Katp Channel Openers Reflect Distinct Atrial and Ventricular Katp Channel Structure in the Murine Heart
Authors: Alexey V Glukhov, Thomas P Flagg, Vadim V Fedorov, Igor R Efimov, Colin G Nichols
Journal: Circulation (2008)

Classically, cardiac sarcolemmal KATP channels are thought to be composed of Kir6.2 (inward-rectifier potassium channel 6.2, KCNJ11) and SUR2A (sulfonylurea receptor type 2A, ABCC9) subunits. However, the evidence is strong that SUR1 (sulfonylurea receptor type 1, ABCC8) subunits are also expressed in the heart and that they play a significant functional role in the atria. To examine this further, we have estimated the effects of potassium channel-opening drugs diazoxide (specific to SUR1 &gt; SUR2A) and pinacidil (SUR2A &gt; SUR1) in intact hearts from wild type (WT, n=6) and SUR1−/− mice (KO, n=3) that lack SUR1 subunits. Action potential duration (APD) in both atria and ventricles were estimated by optical mapping of posterior surface of Langendorff-perfused hearts using the voltage sensitive dye RH237 and high spatiotemporal resolution CMOS camera (100x100 pixels; 3,000 frames/sec). In WT hearts, diazoxide (300 μM) decreased APD in atria (from 33.6±2.1 ms to 25.5±1.0 ms, p&lt;0.001) and did not change it in ventricles (60.0±8.5 ms vs 61.2±8.3 ms, NS). The absence of SUR1 in KO mice resulted in loss of efficacy of diazoxide in atria (37.5±0.7 ms vs 36.5±0.7 ms, NS). In contrast, pinacidil (300 μM) significantly decreased ventricular APD in both type of mice (from 60.0±8.5 ms to 30.5±4.2 ms in WT, p&lt;0.001; and from 62.0±1.4 ms to 30.5±6.4 ms in KO, p&lt;0.001) and did not change atrial APD in either WT or KO hearts. Glass microelectrode recordings from isolated superfused atria confirmed the optical data. In both WT and KO hearts, the APD in left ventricle was significantly longer and the effect of pinacidil was significantly greater than in right ventricle (APD decreasing by 56.3±4.2% and 62.3±12.0% in left ventricle vs 49.4±3.4% and 50.9±4.1% in right ventricle for WT and KO mice respectively, p&lt;0.05). Similar differences between APDs in right and left atria were not observed. Collectively, these results indicate that in the intact mouse heart, significant differential KATP pharmacology in atria and ventricles results from SUR1 predominance in forming the atrial channel, highlighting an unappreciated heterogeneity of KATP function in the heart.
Book: Is Menstruation Obsolete?
Authors: C. De Cree
Journal: BMJ (2001)

Elsimar M Coutinho, Sheldon J Segal Oxford University Press, £15.95, pp 190 ISBN 0 19 5113021 9 Rating: ![Graphic][1]</img>![Graphic][2]</img>![Graphic][3]</img> Menstruation is one of the most prominent anthropological taboos to have left its mark on present day society. Women who are menstruating have been branded as impure and, in a not too distant past, were accused of turning cow's milk sour or causing iron to rust. Elsimar Coutinho claims that “tecurrent menstruation is unnecessary and can be harmful to the health of women. It is a needless loss of blood.” This statement represents the key message of the book. Coutinho advocates an almost … [1]: /embed/inline-graphic-1.gif [2]: /embed/inline-graphic-2.gif [3]: /embed/inline-graphic-3.gif
Colistin–tigecycline versus colistin–imipenem–cilastatin combinations for the treatment of Acinetobacter baumannii ventilator-acquired pneumonia: a prognosis study
Authors: Anis Chaari, Tài Pham, Basma Mnif, Kamilia Chtara, Fatma Medhioub, Najeh Baccouche, Mabrouk Bahloul, Adnène Hammami, Mounir Bouaziz
Journal: Intensive Care Medicine (2015)
Abstract 1510: Oxidative Stress Interferes with Targeted Delivery of Gap Junctions to the Plasma Membrane
Authors: James W Smyth, Ting-Ting Hong, Monika Jain, Tina Fong, Robin M Shaw
Journal: Circulation (2008)

Chronically stressed myocardium has decreased gap junction coupling between cardiomyocytes. The mechanisms underlying this decrease are poorly understood. A common component in stressed myocardium ...
Abstract 18114: Efficacy of Apolipoprotein A-IV as a Vascular Anti-Inflammatory and Anti-Oxidant Agent
Authors: Kate D Shearston, Philip Barter, Ling Yan, Kerry-Anne Rye
Journal: Circulation (2011)

Objective: Apolipoprotein (apo) A-IV, the 3rd most abundant HDL apolipoprotein in human plasma, has anti-inflammatory properties in animal models of colitis and LPS-induced systemic inflammation. This study investigates the ability of apoA-IV to inhibit acute vascular inflammation in the NZW rabbit. Methods: A non-occlusive peri-arterial carotid collar was inserted into normocholesterolemic NZW rabbits (mean weight 3 Kg) 24 h after administering a single intravenous (iv) infusion of either saline or lipid-free apoA-IV (1 mg/kg). The animals were sacrificed 24 h post-collar insertion. Carotid arteries were extracted and analysed immunohistochemically for endothelial expression of vascular cell adhesion molecule-1 (VCAM-1), intercellular adhesion molecule-1 (ICAM-1) and intima/media neutrophil infiltration (CD18+ cells). Human coronary artery endothelial cells (HCAECs) were pre-incubated for 16 h with discoidal reconstituted HDL (rHDL) containing phosphatidylcholine complexed with apoA-IV (final apoA-IV concentration 10 µM/L), then stimulated for a further 5 h with tumour necrosis factor α (TNF- α) (0.2 ng/ml). Cell surface VCAM-1 and ICAM-1 expression was measured by flow cytometry. VCAM-1 and ICAM-1 mRNA levels and the mRNA level of the anti-oxidant and anti-apoptotic enzyme 3β-hydroxysteroid-D24 reductase (DHCR24) were quantified by qPCR. Results: Relative to the saline-infused animals, a single iv infusion of lipid-free apoA-IV decreased collar-induced neutrophil infiltration by 74% and endothelial expression of ICAM-1 and VCAM-1 by 75% and 68%, respectively. Pre-incubation of TNF-α stimulated HCAECs with rHDL reduced ICAM-1 protein and mRNA levels by 34% and 48%, respectively. VCAM-1 protein and mRNA levels were decreased by 61% and 55%, respectively. Pre-incubation of HCAECs with rHDL increased DHCR24 mRNA levels 2.6-fold. Conclusion: ApoA-IV has potent vascular anti-inflammatory and anti-oxidant properties in vitro and in vivo .
Multifunctional liposomes having target specificity, temperature-triggered release, and near-infrared fluorescence imaging for tumor-specific chemotherapy
Authors: Kenji Kono, Munenobu Takashima, Eiji Yuba, Atsushi Harada, Yoshie Hiramatsu, Hiroyuki Kitagawa, Takayuki Otani, Kazuo Maruyama, Sadahito Aoshima
Journal: Journal of Controlled Release (2015)
R-Bendamustine Vs R-CHOP As Initial Treatment for Advanced Stage Low Grade Follicular Lymphoma: A Matched-Pair Analysis
Authors: Karishma Phansalkar, Mohamed Amin Ahmed, Nathan Fowler, Long Ma, Mansoor Noorani, Seung Tae Lee, Lei Feng, Fredrick B. Hagemeister, Jorge E. Romaguera, Luis Fayad, Alma Rodriguez, Felipe Samaniego, Michelle A. Fanale, Michael Wang, Yasuhiro Oki, Francesco Turturro, Jason R. Westin, Loretta J. Nastoupil, Larry W Kwak, Richard E. Davis, Sattva S. Neelapu
Journal: Blood (2014)
Minichromosome maintenance 3(MCM3) and radiation resistance in human hepatocellular carcinoma Hep G2 cells
Authors: Wan-Yee Tang, Pui-Yee Chau, Tim-Tak Kwok
Journal: Cancer Research (2004)

1305   One of the major obstacles in cancer radiotherapy is development of radiation resistance after radiotherapy. To understand the mechanisms of radiation resistance, two radiation conditioned sublines of human hepatocellular carcinoma Hep G2 cells were established respectively from cells survived after two different irradiation regimes, 2 Gy for 10 days or 10 Gy for 2 days. Both radiation conditioned sublines were more resistant to gamma irradiation and also had a greater capacity in potential lethal damage repair (PLDR) than the parent cells as measured by MTT assay. To explore the underlying radiation resistance mechanism, RT-PCR based differential display was performed. Among the cDNA clones that shown differential expression between Hep G2 parent cells and radiation conditioned cells, one of the clones was found to be over-expressed in radiation conditioned cells and have 97% sequence homology with part of the sequence of mcm3 (minichromosome maintenance 3) gene. MCM3 protein is one of the nuclear proteins that are involved in regulation of genome replication. Over-expression of MCM3 in the radiation conditioned cells was subsequently confirmed by Northern blot and Western blot analysis. Furthermore, transfection of cells with antisense mcm3 oligonucleotides was found to increase the radiation sensitivity of Hep G2 cells. The results from this study therefore supported that MCM3 may play an important role in radiation resistance of Hep G2 cells.
Targeted screening and health education for Chagas disease tailored to at-risk migrants in Spain, 2007 to 2010
Authors: M Navarro, A Perez-Ayala, A Guionnet, J A Pérez-Molina, B Navaza, L Estévez, F Norman, M Flores-Chávez, R Lopez-Velez
Journal: Eurosurveillance (2011)

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