tbuckley/cabot-search huggingface dataset:
MEDICAL LORE OF THE AMERICAN INDIANS.
Authors: F. Andros
Journal: JAMA (1883)

Mitchell, D. T, August 6, 1883. <h3>Dear Doctor:</h3> I have been so busy, professionally, that I have neglected an early reply to your two last letters. I think the Winnebagos and Chippewas have no knowledge of their origin. They have a tradition, but it is so merged with superstition that it is wholly improbable. They are all F. F. Vs., and spring from a great and powerful stock. In one thing they agree, that their early home was on the great lakes far to the East, or as they express it "from the rising sun." In a recent conversation with an old trader at Fort Hale, he says the Dacotas have some notion that they came from "the rising sun." I am inclined to the belief that the eastern portion of our continent was first settled, and like the whites they have been pushed west either by stronger or more
Points: A regimen of low dose aspirin
Authors: W. J O'Connell
Journal: BMJ (1983)

December, p 1617) of a patient in whom atenolol treatment apparently precipitated renal artery thrombosis.Recent reports suggest that the angiotensin converting enzyme inhibitor captopril may cause the same complication in patients with pre-existing renal artery stenosis.Oelkers' has described two patients with renovascular hypertension who developed renal artery occlusion during treatment with captopril, and, according to Hollenberg,' about 10% of patients with bilateral renal artery stenosis or stenosis of the artery to a solitary kidney developed rapidly progressive renal failure during the first few weeks of treatment with captopril.Half of these patients recovered renal function with a reduction in dosage of captopril.No details of the remaining patients were given, but one might speculate that some or all of them may also have developed renal artery thrombosis.
Miniature Neurotransmission Regulates Drosophila Synaptic Structural Maturation
Authors: Ben Jiwon Choi, Wendy L. Imlach, Wei Jiao, Verena Wolfram, Ying Wu, Mark Grbic, Carolina Cela, Richard A. Baines, Michael N. Nitabach, Brian D. McCabe
Journal: Neuron (2014)

Miniature neurotransmission is the transsynaptic process where single synaptic vesicles spontaneously released from presynaptic neurons induce miniature postsynaptic potentials. Since their discovery over 60 years ago, miniature events have been found at every chemical synapse studied. However, the in vivo necessity for these small-amplitude events has remained enigmatic. Here, we show that miniature neurotransmission is required for the normal structural maturation of Drosophila glutamatergic synapses in a developmental role that is not shared by evoked neurotransmission. Conversely, we find that increasing miniature events is sufficient to induce synaptic terminal growth. We show that miniature neurotransmission acts locally at terminals to regulate synapse maturation via a Trio guanine nucleotide exchange factor (GEF) and Rac1 GTPase molecular signaling pathway. Our results establish that miniature neurotransmission, a universal but often-overlooked feature of synapses, has unique and essential functions in vivo.
Depression, Burnout and Effort-Reward Imbalance among Psychiatrists
Authors: M. Braun, C. Schönfeldt-Lecuona, R.W. Freudenmann, T. Mehta, B. Hay, H. Kächele, P. Beschoner
Journal: Psychotherapy and Psychosomatics (2010)

17 points, suggesting a mild depression, and 62 (5.7%) scored 6 18 points indicating at least moderate depression. Moreover, 450 of 1,081 (41.6%) psychiatrists indicated they had suffered at least one depressive episode according to the ICD-10 criteria; 152 of 472 (32.2%) reported a depressive episode diagnosed by a specialist; 23 of 1,082 (2.1%) had attempted suicide.
PHENYLBUTAZONE THERAPY OF ARTHRITIS AND OTHER PAINFUL MUSCULOSKELETAL DISORDERS
Authors: Otto Steinbrocker
Journal: JAMA (1952)

This report describes our initial clinical observations on the administration of phenylbutazone (butazolidin®) and of phenylbutazone combined with aminopyrine ("butapyrin") in rheumatoid arthritis and other painful musculoskeletal disorders. These substances were submitted to us for investigation of their reputed analgesic and anti-inflammatory properties in articular and related painful conditions.<sup>1</sup>Owing to the widespread interest already aroused in this country regarding these compounds, we are reporting these early results of our trials of these drugs. Even with the recent contributions of cortisone and corticotropin (ACTH) to the management of the rheumatic disorders, and the availability of other therapeutic agents, there are still many patients for whom these measures are contraindicated or ineffective for one reason or another. In such cases, therefore, there remains a real need for a sound and useful therapeutic preparation, even if its action proves merely palliative. Recently the synthetic derivative of pyrazol, called phenylbutazone (3,5-dioxo-1,2 diphenyl-4-n
THE USE OF AMIDOPYRINE IN A CASE OF DIABETES INSIPIDUS
Authors: Bernard S. Kahn
Journal: JAMA (1933)

In July, 1932, Scherf<sup>1</sup>made a report on the use of amidopyrine in the treatment of diabetes insipidus. I had at that time a patient suffering from this disease whose only relief from the great frequency of urination was daily injection of a pituitary preparation. Numerous attempts to alleviate his symptoms by oral administration of large doses of desiccated pituitary gland, and by the intranasal use of sprays and tampons saturated with a potent preparation of double strength solution of pituitary or ampules of pitressin were all without avail. The use of a snuff made from desiccated whole pituitary gland was also ineffective, not the slightest relief being obtained from any of these procedures. The use of amidopyrine according to Scherf seemed to offer some hope. The patient, H. B., is a man, 6 feet (183 cm.) in height and weighing 160 pounds (72 Kg.). Before the onset of
Chronic Severe Hemolytic Anemia from Phenazopyridine
Authors: Mumtaz A. Siddiqui
Journal: Annals of Internal Medicine (1995)

Letters15 January 1995Chronic Severe Hemolytic Anemia from PhenazopyridineMumtaz A. SiddiquiMumtaz A. SiddiquiSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-122-2-199501150-00023 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:The case report by Thomas and colleagues [1] is interesting. Phenazopyridine (Sedural or Pyridium), an azo dye, is not an over-the-counter drug. The other common medications having phenazopyridine in combination with sulfamethoxazole and sulfisoxazole are Azo Gantanol and Azo Gantrisin, respectively [2]. None of the preparations of phenazopyridine is available over the counter. I wonder whether the patient or her husband was, in fact, getting the drug by “inadvertent” prescription.Further, oxidative Heinz-body hemolytic anemia with “bite cells” (degmacytes) is well documented as occurring after chronic overdosing with phenazopyridine [2, 3]. Glucose-6-phosphate dehydrogenase deficiency in erythrocytes may ...References1. Thomas RJ, Doddabele S, Karnad AB. Chronic severe hemolytic anemia related to surreptitious phenazopyridine abuse. Ann Intern Med. 1994; 121:308. Google Scholar2. Physicians' Desk Reference. 48th ed. Montvale, New Jersey: Medical Economics; 1994; 1914-5: 1971. Google Scholar3. Drug: Facts and Comparisons. 48th ed. St. Louis: Wolter Kluwer; 1994:2881-2. Google Scholar4. Kornowski R, Averbuch M, Jaffe A, Schwartz D, Levo Y. Sedural toxicity. Harefuah. 1991; 120:324-5. Google Scholar Author, Article, and Disclosure InformationAffiliations: PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byUrinary tract analgesics for the treatment of patients with acute cystitis: where is the clinical evidence? 15 January 1995Volume 122, Issue 2Page: 156-157KeywordsCellsDrugsGlucose-6-phosphate dehydrogenase deficiencyHemolytic anemiaOver the counter drugs Issue Published: 15 January 1995 Copyright & PermissionsCopyright © 1995 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Alzheimer's 1, Tom nil
Authors: Shirley Willsher
Journal: New England Journal of Medicine (1999)

To the Editor: Krag et al. (Oct. 1 issue) 1 present interesting data on the use of probe-guided resection of radioactive sentinel nodes in patients with breast cancer, but they conclude that "the procedure can be technically challenging, and the success rate varies according to the surgeon."In our opinion, preoperative lymphoscintigraphy can facilitate surgical localization and excision of the sentinel node and increase the detection rate.Lymphoscintigraphy is a nuclear-medicine procedure that is easy to perform and, in conjunction with the intraoperative gamma probe, has been successfully used primarily in patients with malignant melanoma or breast cancer. 2,3The main advantage of this imaging technique is that it allows accurate preoperative localization of the sentinel node; after scintigraphic images have been obtained, a mark can be made on the skin that corresponds to the first lymph node detected by the gamma camera, thereby indicating precisely where the incision should be made.The use of the gamma probe during surgery then guides dissection, making the node biopsy easier and consistently successful.In most patients, the sentinel node is visible within 30 minutes after the injection, regardless of the size of the radiolabeled particles used, when they are injected subdermally. 4Lymphoscintigraphy is not time-consuming; anterior and lateral views, each obtained within five minutes, are sufficient to identify another 10 percent of sentinel nodes that might have not been detected with the use of a probe survey alone. 5
Comparative Hemodynamic, Left Ventricular Functional, and Antiadrenergic Effects of Chronic Treatment With Metoprolol Versus Carvedilol in the Failing Heart
Authors: Edward M. Gilbert, William T. Abraham, Stephanie Olsen, Brack Hattler, Michel White, Patrice Mealy, Patti Larrabee, Michael R. Bristow
Journal: Circulation (1996)

Background The basic pharmacology of the third-generation β-blocking agent carvedilol differs considerably from second-generation compounds such as metoprolol. Moreover, carvedilol may produce different, ie, more favorable, clinical effects in chronic heart failure. For these reasons, we compared the effects of carvedilol and metoprolol on adrenergic activity, receptor expression, degree of clinical β-blockade, hemodynamics, and left ventricular function in patients with mild or moderate chronic heart failure. Methods and Results The effects of carvedilol versus metoprolol were compared in two concurrent placebo-controlled trials with carvedilol or metoprolol that had common substudies focused on adrenergic, hemodynamic, and left ventricular functional measurements. All subjects in the substudies had chronic heart failure resulting from idiopathic dilated cardiomyopathy. Carvedilol at 50 to 100 mg/d produced reductions in exercise heart rate that were similar to metoprolol at 125 to 150 mg/d, indicating comparable degrees of β-blockade. Compared with metoprolol, carvedilol was associated with greater improvement in New York Heart Association functional class. Although there were no significant differences in hemodynamic effects between the carvedilol and metoprolol active-treatment groups, carvedilol tended to produce relatively greater improvements in left ventricular ejection fraction, stroke volume, and stroke work compared with changes in the respective placebo groups. Carvedilol selectively lowered coronary sinus norepinephrine levels, an index of cardiac adrenergic activity, whereas metoprolol did not lower coronary sinus norepinephrine and actually increased central venous norepinephrine levels. Finally, metoprolol was associated with an increase in cardiac β-receptor density, whereas carvedilol did not change cardiac β-receptor expression. Conclusions The third-generation β-blocking agent carvedilol has substantially different effects on left ventricular function, hemodynamics, adrenergic activity, and β-receptor expression than does the second-generation compound metoprolol. Some or all of these differences may explain the apparent differences in clinical results between the two compounds.
Evaluation of previously nonscreened hereditary hemorrhagic telangiectasia patients shows frequent liver involvement and early cardiac consequences
Authors: Rodica Gincul, Gaetan Lesca, Bénédicte Gelas-Dore, Nathalie Rollin, Martine Barthelet, Sophie Dupuis-Girod, Franck Pilleul, Sophie Giraud, Henri Plauchu, Jean-Christophe Saurin
Journal: Hepatology (2008)

Hereditary hemorrhagic telangiectasia (HHT) is a genetic disease characterized by cutaneous, mucosal, and sometimes visceral arteriovenous malformations. Severe hepatic manifestations have been characterized in a subgroup of patients, but few data are available in previously nonscreened patients. We prospectively evaluated liver involvement and its cardiac consequences in such patients. Between 2000 and 2005, we prospectively evaluated the clinical, biological, and hepatic Doppler sonography (DS) characteristics of 102 consecutive HHT patients (mean age, 52.5 years; range, 19-88; 80.4%) with an identified genetic mutation. Patients were segregated into three different severity groups according to DS values. Factors predictive of an abnormal DS, according to predetermined criteria, and of a high cardiac index were identified by logistic and linear regression analysis, respectively. Abnormal liver biology and clinical signs of hepatic involvement were present in 35.3% and 27.5% of cases, respectively. Abnormal DS (defined as at least enlargement of the main hepatic artery) was observed in 56 (54.9%) cases, and direct or indirect signs of significant fistulas were present in 26 (25.5%) cases. Abnormal liver biology and a mutation involving the ACVRL1 gene were predictive of hepatic ultrasound (US) abnormalities. The diameter of the main hepatic artery and the presence of focal nodular hyperplasia (FNH) were predictive of a higher cardiac index.This large prospective series of previously nonscreened HHT patients identified a subgroup at risk of liver involvement (patients with abnormal liver biology and ACVRL1 mutations) and a subgroup with a higher cardiac index: future studies will show whether such patients would benefit from systematic DS screening and long-term cardiac surveillance.
TWIN STUDIES ON SENESCENCE
Authors: FRANZ J. KALLMANN, GERHARD SANDER
Journal: American Journal of Psychiatry (1949)

1. By means of the twin family method and up to the end of 1947, a representative sample of 1,602 twin index cases over 6o years of age was collected from both the general and institutionalized populations of the state of New York, in order to study the biological, social, and psychiatric problems of senescence under experiment-like, but mankind-specific conditions. The study was organized in such a way that complete life histories can be obtained for the purpose of analyzing the differences observed between one-egg and two-egg twin groups with regard to length of life, senile manifestations, and causes of death. 2. The random sampling of the series of aged twins included in this preliminary analysis is indicated not only by the sex distribution of the index cases (697 males to 905 females), but also by the obtained ratio of monozygotic to dizygotic pairs (237 to 548). 3. Many basic elements in the physical and psychological similarities of one-egg twin partners have a tendency to persist throughout life and definitely exceed those found in two-egg pairs, frequently withstanding advancing age as well as significant environmental diversity. Intellectual abilities have also been shown psychometrically to depend on genetically produced potentialities, which in their measurable effects remain variable from man to man until senescence. 4. Married one-egg twin partners of either sex differ less in their rates of reproductivity than do same-sexed dizygotic twin pairs. This finding disagrees with the popular notion that the female partner is the chief determining factor in the regulation of family size. 5. In comparing the life spans of same-sexed twins, the average intra-pair difference of monozygotic pairs has been found to be only one-half that of dizygotic pairs, indicating the significance of genetic factors in longevity. The total mean difference is 36.9 months in the monozygotic group, and 78.3 months in the same-sexed dizygotic group. 6. The biology of senescence cannot be clearly understood without reference to life itself in terms of the variable capacity for survival.
My Second Wind
Authors: Clayton J. Baker
Journal: Annals of Internal Medicine (2009)

Ad Libitum17 February 2009My Second WindClayton J. Baker, MDClayton J. Baker, MDFrom Pittsford, NY 14534-4727.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-150-4-200902170-00014 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail catches up predictablyabout four, four and a halfmiles in.Physiologically,something clicks. Gravity halvesand airbreathes hyperbarically,for two miles more my feet haveto grin.Fatigue then insistentlywearies, till rest proves it hasmy ear.Clayton J. Baker, MDPittsford, NY 14534-4727 Author, Article, and Disclosure InformationAffiliations: From Pittsford, NY 14534-4727.Current Author Address: Clayton J. Baker, MD, Pittsford, NY 14534-4727. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 17 February 2009Volume 150, Issue 4Page: 281KeywordsFatigue ePublished: 17 February 2009 Issue Published: 17 February 2009 Copyright & PermissionsCopyright © 2009 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Human Circulating PD-1+CXCR3−CXCR5+ Memory Tfh Cells Are Highly Functional and Correlate with Broadly Neutralizing HIV Antibody Responses
Authors: Michela Locci, Colin Havenar-Daughton, Elise Landais, Jennifer Wu, Mark A. Kroenke, Cecilia L. Arlehamn, Laura F. Su, Rafael Cubas, Mark M. Davis, Alessandro Sette, Elias K. Haddad, Pascal Poignard, Shane Crotty
Journal: Immunity (2013)
Gallbladder motility and cholecystokinin secretion in chronic pancreatitis: relationship with exocrine pancreatic function
Authors: Hugo A.J. Gielkens, Eric-Hans Eddes, Juda Vecht, Jaques A. van Oostayen, Cornelis B.H.W. Lamers, Ad A.M. Masclee
Journal: Journal of Hepatology (1997)
Moonlighting: Wax Without the Wane
Authors: Philip Lempert
Journal: JAMA (1964)

<h3>To the Editor:—</h3> I have great difficulty in appreciating the delicate sensibilities of the attending staff whose integrity may be stained by the moonlighting residents whose actions are a direct result of the blindness and callousness of their mentors. The 30-year-old or older resident with a family to support on $3,000 or less a year receives my deepest and sincerest sympathies. The "crying shame" is that such situations are still tolerated.
TCT-203 Reproducibility of in Vivo Virtual Histology Intravascular Ultrasound Evaluation of the Carotid Atherosclerotic Plaque Using Novel Quantitative Parameters
Authors: Piotr Musialek, Wladyslaw Dabrowski, Lukasz Tekieli, Piotr Pieniazek, Adam Mazurek, Krzysztof Zmudka, Wieslawa Tracz, Piotr Podolec
Journal: Journal of the American College of Cardiology (2012)
Expression of reelin in hepatic stellate cells and during hepatic tissue repair: a novel marker for the differentiation of HSC from other liver myofibroblasts
Authors: Dominik Kobold, Anka Grundmann, Fabio Piscaglia, Christoph Eisenbach, Katrin Neubauer, Jürgen Steffgen, Giuliano Ramadori, Thomas Knittel
Journal: Journal of Hepatology (2002)
Streptococcus milleri as a cause of pleural empyema.
Authors: D B Hocken, J E Dussek
Journal: Thorax (1985)

Review of an annual series of cases of empyema seen at a regional cardiothoracic unit showed that six out of 25 were due to Streptococcus milleri. The details of the cases are summarised. This organism is now an important cause of empyema, occurring much more commonly in men than in women; but since it is highly sensitive to penicillins permanent resolution can be achieved with antibiotic treatment combined with open or closed drainage.
The utility of prostate-specific antigen for detecting prostate cancer
Authors: J. C. Peirce
Journal: JAMA (1995)

To the Editor.  —In their study of the validity of PSA in detecting prostate cancer, Dr Gann and colleagues 1 provide valuable information reducing spectrum bias by doing a nested case-control study from a cohort of men followed for at least 10 years and stratifying the results by aggressive and nonaggressive tumors. Unfortunately, the authors report their results as sensitivity and specificity, necessitating dichotomous results, or odds ratios at several levels of PSA. The validity of diagnostic or screening tests are better determined by likelihood ratios (LRs), which allow clinicians to ascertain whether the probability of prostate cancer is revised downward (if the LR is  1.0), with the magnitude of the revision determined by the numerical value of the LR. 2   Using the method of Peirce and Cornell, 3 I calculated the LRs for PSA in detecting aggressive cancers based on the seven
1101-65 Predictors of edge stenosis following sirolimus-eluting stent deployment: A quantitative intravascular ultrasound analysis from the SIRIUS trial
Authors: Ryota Sakurai, Junya Ako, Shinjo Sonoda, Hideaki Kaneda, Yoshihiro Morino, Mitsuya Terashima, Ali Hassan, Paul G Yock, Martin B Leon, Jeffrey W Moses, Peter J Fitzgerald, Yasuhiro Honda
Journal: Journal of the American College of Cardiology (2004)
SPONTANEOUS RUPTURE OF THE EYEBALLA PHENOMENON OF GLAUCOMA
Authors: E. C. ELLETT
Journal: JAMA (1910)

<h3>Author's Case.—</h3> Mr. S. C., aged 68, resident of Kentucky on a visit to Memphis, had been given a letter of introduction to me by Dr. J. M. Ray of Louisville. On the night of Dec. 9, 1904, about 9 o'clock, I was called to see him on account of a sudden pain in his left eye, accompanied by bleeding. He had undressed and retired, and afterward felt a desire to go to stool. His bowels moved without straining, and he again retired. After lying down he began to bleed from the left eye, and immediately to experience a severe pain. I found him still suffering such pain as to require half a grain of morphin to relieve him. The eye showed a large clot protruding from a rupture in the cornea, the corneal wound being about 10 mm. long. Oozing of blood was still going on, and the eye