High Prevalence of Hyperamylasemia in Patients with Acidemia
Authors: John H. Eckfeldt, James W. Leatherman, Michael D. Levitt
Journal: Annals of Internal Medicine (1986)

Brief Reports1 March 1986High Prevalence of Hyperamylasemia in Patients with AcidemiaJOHN H. ECKFELDT, M.D., Ph.D., JAMES W. LEATHERMAN, M.D., MICHAEL D. LEVITT, M.D.JOHN H. ECKFELDT, M.D., Ph.D.Search for more papers by this author, JAMES W. LEATHERMAN, M.D.Search for more papers by this author, MICHAEL D. LEVITT, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-104-3-362 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptA diagnosis of acute pancreatitis usually depends on the finding of elevated serum amylase activity. Although a low-grade elevation of serum amylase is a relatively non-specific finding, most acutely ill patients with appreciable elevations of serum amylase activity are considered to have acute pancreatitis (1-3). However, many nonpancreatic conditions produce marked elevations in serum amylase activity (1-3). One condition that has received considerable attention is diabetic ketoacidosis (4). Because we noted elevations of serum amylase in the apparent absence of clinical pancreatitis in several nondiabetic patients with acidemia in our intensive care unit, we decided to measure prospectively serum total...References1. SALT W and SCHENKER S. Amylase—its clinical significance: a review of the literature. Medicine (Baltimore). 1976;55:269-89. CrossrefMedlineGoogle Scholar2. BAYSE D, DUNCAN P, and MATHER A. Amylase in serum and urine. In: HOMBURGER HA, ed. Clinical and Analytical Concepts in Enzymology. Skokie, Illinois: College of American Pathologists; 1983:173-94. Google Scholar3. STEINBERG W, GOLDSTEIN S, DAVIS N, SHAMMA A, and ANDERSON K. Diagnostic assays in acute pancreatitis: a study of sensitivity and specificity. Ann Intern Med. 1985;102:576-80. LinkGoogle Scholar4. GOLDBERG D, SPOONER R, and KNIGHT A. Proceedings: serum amylase and related enzymes in diabetic ketoacidosis. J Clin Pathol. 1973;26:985-94. CrossrefMedlineGoogle Scholar5. GILBERT R. Spirometry and blood gases. In: TODD JC, SANFORD AH, DAVIDSON I, HENRY JB, eds. Clinical Diagnosis and Management by Laboratory Methods. New York: W. B. Saunders Company; 1979:107-43. Google Scholar6. O'CONNOR C and MCGEENEY K. Isolation and characterization of four inhibitors from wheat flour which display differential inhibition specificities for human salivary and human pancreatic alpha-amylases. Biochim Biophys Acta. 1981;658:387-96. CrossrefMedlineGoogle Scholar7. OKABE H, UJI Y, NETSU K, and NOMA A. Automated measurement of amylase isoenzymes with 4-nitrophenyl-maltoheptoside as substrate and a selective amylase inhibitor. Clin Chem. 1984;30:1219-22. CrossrefMedlineGoogle Scholar8. LEVITT M and ELLIS C. A rapid and simple assay to determine if macro-amylase is the cause of hyperamylasemia. Gastroenterology. 1982;83:378-82. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: JOHN H. ECKFELDT, M.D., Ph.D.; JAMES W. LEATHERMAN, M.D.; MICHAEL D. LEVITT, M.D.Affiliations: University of Minnesota and Veterans Administration Medical Center Minneapolis, Minnesota PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byPANCREATITIS OR NOT? – Elevated lipase and amylase in ICU patientsAcute PancreatitisMacroamylasemia in a patient with acute myeloid leukemiaConduite à tenir devant une élévation des enzymes pancréatiques de découverte fortuiteHyperamylasemia and Acidemia: Is There an Association?Macroamylasemia in a Patient with Multiple Myeloma10 Pancreatic lesions in HIV-infected patientsPancreatic endocrine function in cystic fibrosisAcidocétose chez une alcoolique chroniqueWhere Does Serum Amylase Come From and Where Does It Go?PancreatitisDiagnostic Enzymes for Pancreatic DiseaseAcid-Base Physiology and PathophysiologySerum amylase levels in ectopic pregnancyDiabetic Ketoacidosis: An Update 1 March 1986Volume 104, Issue 3Page: 362-363KeywordsAcute pancreatitisIntensive care unitsPancreatitis ePublished: 1 December 2008 Issue Published: 1 March 1986 PDF downloadLoading ...