A THEORY EXPLAINING THE LOCAL MECHANISM FOR GASTRIC MOTOR AND SECRETORY CONTROL AND THE ALTERATION OF THESE FUNCTIONS IN UNCOMPLICATED DUODENAL ULCER
Authors: Harry Shay, J. Gershon-Cohen, Samuel S. Fels
Journal: Annals of Internal Medicine (1942)

Article1 April 1942A THEORY EXPLAINING THE LOCAL MECHANISM FOR GASTRIC MOTOR AND SECRETORY CONTROL AND THE ALTERATION OF THESE FUNCTIONS IN UNCOMPLICATED DUODENAL ULCERHARRY SHAY, M.D., J. GERSHON-COHEN, M.D., D.SC. (MED.), SAMUEL S. FELS, LL.D.HARRY SHAY, M.D.Search for more papers by this author, J. GERSHON-COHEN, M.D., D.SC. (MED.)Search for more papers by this author, SAMUEL S. FELS, LL.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-16-4-772 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe symptomatology of duodenal ulcer is due in large part to the disordered gastric physiology. It is also true that if an adequate explanation for the disordered physiology were available, therapy could possibly be directed into more physiological channels than is now the practice. The disordered gastric function in duodenal ulcer, as is well known, takes the form of both motor and secretory changes. In uncomplicated cases, the abnormal motor phenomena are hyperperistalsis, hypertonicity, and hypermotility. The secretory abnormality is hypersecretion. These abnormal gastric findings have long been recognized, but no suitable explanation for their existence has as yet been...Bibliography1. SHAYGERSHON-COHEN HJ: Experimental studies in gastric physiology in man. II. A study of pyloric control. The rôles of acid and alkali, Surg., Gynec. and Obst., 1934, lviii, 935. Google Scholar2. SHAYGERSHON-COHENFELS HJSS: The rôle of the upper small intestine in the control of gastric secretion; the effect of neutral fat, fatty acid and soaps; the phase of gastric secretion influenced and the relative importance of the psychic and chemical phases, ANN. INT. MED., 1939, xiii, 294. Google Scholar3. SHAYGERSHON-COHENFELS HJSS: On a self-regulatory duodenal mechanism for gastric acid control and an explanation for the pathologic gastric physiology in duodenal ulcer, Am. Jr. Digest. Dis. and Nutr. (to be published). Google Scholar4. GERSHON-COHENSHAY JH: Experimental studies on gastric physiology in man. III. A study of pyloric control. The rôle of milk and cream in the normal and in subjects with quiescent duodenal ulcer, Am. Jr. Roentgenol., 1937, xxxviii, 427-446. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Philadelphia, Pennsylvania*Read before The Section on General Medicine of the College of Physicians of Philadelphia, May 26, 1941.Received for publication September 24, 1941.From the Medical Research Laboratory Samuel S. Fels Fund and the Gastro-Intestinal Division, Medical Service I, Mt. Sinai Hospital, Philadelphia, Pa.With the technical assistance of Herman Siplet, A.B. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byPlasma secretin concentrations in fasting and postprandial state in manSerum Gastric Inhibitory Polypeptide (GIP) in Duodenal Ulcer Disease: Relationship to Glucose Tolerance, Insulin, and Gastrin ReleaseThe Duodenal Mechanism in the Control of Gastric MotilityCritique on Vagotomy 1 April 1942Volume 16, Issue 4Page: 772-781KeywordsDuodenal ulcersGastroenterology and hepatologyHypertonicityMedical servicesResearch laboratories ePublished: 1 December 2008 Issue Published: 1 April 1942 PDF downloadLoading ...