WATER DIURESIS IN ADRENAL CORTICAL INSUFFICIENCY
Authors: A E THOMSON, E G BROWNELL, G R CUMMING
Journal: Annals of Internal Medicine (1960)

Article1 May 1960WATER DIURESIS IN ADRENAL CORTICAL INSUFFICIENCYA. E. THOMSON, M.D., F.R.C.P.(C), E. G. BROWNELL, M.D., F.A.C.P., F.R.C.P.(C), G. R. CUMMING, M.D., F.R.C.P.(C)A. E. THOMSON, M.D., F.R.C.P.(C)Search for more papers by this author, E. G. BROWNELL, M.D., F.A.C.P., F.R.C.P.(C)Search for more papers by this author, G. R. CUMMING, M.D., F.R.C.P.(C)Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-52-5-949 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptOne of the earliest and most widely used screening tests for adrenal cortical insufficiency was that proposed by Robinson, Power and Kepler, which depended upon the inability of patients with Addison's disease to show a normal water diuresis. This procedure was subsequently found to exclude erroneously some cases of Addison's disease.1, 2Moreover, the required 12-hour period of fluid restriction and the relatively large water load of 20 ml./Kg. were capable of inducing crises in the adrenal-deficient subject. In many centers a more direct method of diagnosis, by measurement of the changes in 17-hydroxycorticoid excretion before and after ACTH, superseded...Bibliography1. RobinsonPowerKepler JFMHEJ: Two new procedures to assist in the recognition and exclusion of Addison's disease: a preliminary report, Proc. Staff Meet., Mayo Clin. 16: 577, 1941. Google Scholar2. LevyPowerKepler MSMHEJ: The specificity of the "water test" as a diagnostic procedure in Addison's disease, J. Clin. Endocrinol. 6: 607, 1946. CrossrefGoogle Scholar3. SofferGabrilove LJJL: A simplified water-loading test for the diagnosis of Addison's disease, Metabolism 1: 504, 1952. MedlineGoogle Scholar4. 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CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Winnipeg, Manitoba, Canada*Received for publication December 29, 1959.From the Department of Medicine, University of Manitoba, Winnipeg, Manitoba, Canada.Requests for reprints should be addressed to A. E. Thomson, M.D., The University of Manitoba Faculty of Medicine, Medical Buildings, Bannatyne and Emily, Winnipeg 3, Canada. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byAddison Disease Presenting with Acute Neurologic Deterioration: A Rare Presentation Yields New Lessons from Old Observations in Primary Adrenal FailurePostconcussive hyperosmolality and deficient thirstEndokrinologische DiagnostikPhysiology of the kidneyAssessment of Adrenocortical Function 1 May 1960Volume 52, Issue 5Page: 949-959KeywordsAdrenocorticotropic hormoneCirrhosisDiureticsExcretionIngestion ePublished: 1 December 2008 Issue Published: 1 May 1960 Copyright & PermissionsCopyright ©, 1960, by The American College of PhysiciansPDF downloadLoading ...