tbuckley/cabot-search huggingface dataset:
Elevated monoclonal and polyclonal serum immunoglobulin free light chain as prognostic factors in B- and T-cell non-Hodgkin lymphoma
Authors: Thomas E. Witzig, Matthew J. Maurer, Thomas M. Habermann, Brian K. Link, Ivana N.M. Micallef, Grzegorz S. Nowakowski, Stephen M. Ansell, Joseph P. Colgan, David J. Inwards, Luis F. Porrata, Svetomir N. Markovic, Patrick B. Johnston, Yi Lin, Carrie Thompson, Mamta Gupta, Jerry A. Katzmann, James R. Cerhan
Journal: American Journal of Hematology (2014)

The serum immunoglobulin free light chain (FLC) assay quantitates free kappa (κ) and lambda (λ) light chains. FLC elevations in patients with diffuse large B-cell lymphoma (DLBCL), Hodgkin lymphoma (HL), and chronic lymphocytic leukemia (CLL) are associated with an inferior survival. These increases in FLC can be monoclonal (as in myeloma) or polyclonal. The goal was to estimate the frequency of these elevations within distinct types of B-cell and T-cell non-Hodgkin lymphoma (NHL) and whether the FLC measurements are associated with event-free survival (EFS). We studied serum for FLC abnormalities using normal laboratory reference ranges to define an elevated κ or λ FLC. Elevations were further classified as polyclonal or monoclonal. Four hundred ninety-two patients were studied: 453 B-cell and 34 T-cell NHL patients. Twenty-nine % (142/453) of patients had an elevated FLC of which 10% were monoclonal elevations. Within B-cell NHL, FLC abnormalities were most common in lymphoplasmacytic (79%), mantle cell (68%), and lymphomas of mucosa associated lymphoid tissue (31%); they were least common in follicular (15%). The hazard ratio (HR) for EFS in all patients was 1.41 (95% CI; 1.11–1.81); in all B-cell NHL the HR was 1.44 (95% CI 1.11–1.96); in all T-cell NHL the HR was 1.17 (95% CI 0.55–2.49). FLC abnormalities predicted an inferior OS (HR = 2.75, 95% CI: 1.93–3.90, P < 0.0001). The serum FLC assay is useful for prognosis in both B-cell and T-cell types of NHL. In B-cell NHL further discrimination between a monoclonal and polyclonal elevation may be helpful and should be analyzed in prospective clinical trials. Am. J. Hematol. 89:1116–1120, 2014. © 2014 Wiley Periodicals, Inc.
Accidents and Emergencies. A Practical Handbook for Personal Use.
Authors: R. H. Hardy
Journal: Annals of Internal Medicine (1982)

In the new edition of this handbook the common conditions that are encountered in an Accident and Emergency Department are covered in alphabetical order, along with a comprehensive index which may be useful for cross-referencing. Alternate pages are left blank for the addition of personal notes and local information and variations, so that the reader can produce a personal handbook for day-to-day use. The book is intended to provide practical advice for the casualty officer facing unfamiliar situations and expected to make immediate decisions.
New Formulation of Tripedia
Authors: Bernard A. Schwetz
Journal: JAMA (2001)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Preeclampsia, Placental Insufficiency, Autism, and Antiphospholipid Antibodies
Authors: Lionel Carbillon, Eric Lachassinne, Arsene Mekinian
Journal: JAMA Pediatrics (2015)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Pediatrics HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Pediatrics journal
Lesson of the week: Mercury poisoning after spillage at home from a sphygmomanometer on loan from hospital
Authors: A C Rennie, M McGregor-Schuerman, I M Dale, C Robinson, R McWilliam
Journal: BMJ (1999)

Be aware of the potential for toxicity of mercury spilled from broken medical equipment.

When patients are managed at home, they or their carers have to operate medical equipment. This case report highlights important educational and environmental health aspects of issuing hospital equipment for home use, a practice that is likely to become more common in the future. We describe a 9 year old boy who had neurological and renal complications after mercury spillage from a sphygmomanometer three months after it had been provided by the hospital for monitoring blood pressure at home. The family were unaware of the potential risks of mercury exposure before the patient became acutely ill.

A 9 year old boy presented to his local hospital with a three week history of abdominal pain, constipation, lethargy, limb pain, and unsteadiness. Physical examination showed mild facial weakness, areflexia, ataxia, and impaired sensation and led to a provisional diagnosis of Guillaine-Barre syndrome. The boy's constant restlessness was considered strange, but his mother described him as hyperactive and regarded this behaviour as normal. It was noted, however, that his handwriting and schoolwork had deteriorated over the preceding month.

Features of encephalopathy accompanied by peripheral neuropathy led to a suspicion of …
Seniors Seeking Health Information Need Help Crossing “Digital Divide”
Authors: Rebecca Voelker
Journal: JAMA (2005)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
6-month follow-up in patients with advanced homogeneous emphysema treated with endobronchial lung sealant therapy
Authors: Arschang Valipour, Felix Herth, Ralf Eberhardt, Franz Stanzel, Reiner Bonnet, Juergen Behr, Charles Marquette, Mordechai Kramer
Journal: European Respiratory Journal (2011)

Objective(s):  Bronchoscopic lung volume reduction therapy using endobronchial valves (Scuirba F et al., NEJM, 2010;363) and coils (Herth FJ et al. Therap Adv Resp Dis, 2010;4) has shown limited efficacy in patients with advanced homogenous emphysema (AHoE). This study summarizes responses to AeriSeal® Emphysematous Lung Sealant (ELS) therapy in patients with AHoE out to 6 months.   Methods:  Patients with AHoE and scintigraphy scans showing reduced perfusion to the upper lung zones (n=12) were included in this study, which was performed at 8 investigational centers in Europe and Israel. All patients received initial 2-site upper lobe bronchoscopic ELS therapy; approximately 2/3 received a second treatment at 2 additional sites in the contralateral lung. Follow-up was performed at 3 and 6 months post treatment.   Results:  Upper lobe ELS therapy in this cohort of AHoE patients (8 male, age 64±7 yrs) was well tolerated, and was associated with improvements in pulmonary function, functional capacity, and quality of life. Three (3) and 6 month changes in FEV 1  (+12.6±13.1%; 9.5±13.9%), FVC (8.1±12.1%; 8.6±13.1%), RV/TLC ratio (-3.6±8.7%; -5.1±8.3%), MRCD (-0.2±0.83U; -0.4±0.90U), 6MWT (+15.4±45.8m; +16.6±47.7m), and SGRQ (-7.9±17.6U; -13.3±23.0U) were observed. MCID improvements in spirometry (>12% improvement in FEV 1  and/or FVC) were observed in ≥ 50% of patients at both time points.   Conclusions:  ELS therapy produces durable improvements in pulmonary function and quality of life in patients with AHoE, and represents a new therapeutic option for patients with homogeneous emphysema who remain symptomatic despite maximal medical therapy.
Interferon-Beta Signaling Regulates Arteriogenesis Through its Effects on Monocyte Apoptosis and Smooth Muscle Cell Proliferation
Authors: Stephan H. Schirmer, Joost O. Fledderus, Anja M. van der Laan, Anton J. Horrevoets, Jan J. Piek, Imo E. Hoefer, Niels van Royen
Journal: Circulation (2008)
THE DEVELOPMENT AND IMPORTANCE OF HYPERTENSION IN CHRONIC BRIGHT'S DISEASE
Authors: Herman O. Mosenthal, Howard H. Lander
Journal: Annals of Internal Medicine (1939)

Article1 March 1939THE DEVELOPMENT AND IMPORTANCE OF HYPERTENSION IN CHRONIC BRIGHT'S DISEASEHERMAN O. MOSENTHAL, M.D., F.A.C.P., HOWARD H. LANDER, M.D.HERMAN O. MOSENTHAL, M.D., F.A.C.P.Search for more papers by this author, HOWARD H. LANDER, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-12-9-1449 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe elevation of blood pressure characteristic of chronic Bright's disease is usually believed to occur in two ways: first, without any renal involvement whatsoever—primary or essential hypertension; second, as the result of renal insufficiency—secondary hypertension.However, the development of increased arterial tension before impairment of renal function is present, occurs commonly in cases of chronic diffuse glomerular nephritis, whose initial, dominant, often sole sign is albuminuria. A study of 124 cases shows that 36 per cent had a normal bloodpressure, 19 per cent had an elevation of blood pressure associated with marked renal insufficiency, and 45 per cent had...Bibliography1. TIEGERSTEDTBERGMAN RPG: Niere und Kreislauf, Skand. Arch. f. Physiol., 1898, viii, 223. CrossrefGoogle Scholar2. GOLDBLATT H: Experimental hypertension induced by renal ischemia, The Harvey Lectures, 1938, xxxiii, 237. Google Scholar3. SHAW HB: Auto-intoxication: Its relation to certain disturbances of blood pressure, Lancet, 1906, i, 1295, 1375, 1455. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: New York, N. Y.*Read before the Meeting of the Association of American Physicians, Atlantic City, N. J., May 3, 1938.From the Department of Medicine, New York Post-Graduate Medical School and Hospital, New York, N. Y. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited bySplanchnicotomy in a six-year old child with marked hypertension 1 March 1939Volume 12, Issue 9Page: 1449-1454KeywordsBlood pressureGlomerulonephritisHospital medicineHypertensionNephritis Issue Published: 1 March 1939 PDF downloadLoading ...
Abstract 18460: Post-Norwood Intensive Care Management and Patient Experience: Summary from the Joint Council for Congenital Heart Disease National Pediatric Cardiology Quality Improvement Collaborative Registry
Authors: Carissa Baker-Smith, Steven R Neish, Geoffrey L Rosenthal, Robert H Beekman, Kathy J Jenkins, John D Kugler, Gerard R Martin, Carole Lannon
Journal: Circulation (2010)

Collaborative quality initiatives significantly improve care and outcomes in patients with chronic disease. One in four children with hypoplastic left heart syndrome (HLHS) die between the first an...
Physicians Condemn Torture
Authors: Mike Mitka
Journal: JAMA (2005)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Calcium antagonists not best for first line therapy for hypertension
Authors: David Spurgeon
Journal: BMJ (2000)

A meta-analysis of trials involving 27 743 people has shown that calcium antagonists are inferior to other types of antihypertensive drugs as first line agents in reducing the risks of several major complications of hypertension, although they are equally effective in reducing blood pressure.

In an article in the Lancet , the researchers (from Wake Forest University, Winston Salem, North Carolina; the University of Washington, Seattle, Washington; and Albert Einstein College of Medicine, Bronx, New York) concluded that “the longer-acting calcium antagonists cannot be recommended as first-line therapy for hypertension.”

Lead researcher Marco Pahor, professor of medicine at Wake Forest University's Baptist …
The dendrogenine A: a new aminosteroid for the immunotherapy of cancers.
Authors: Marc E. Poirot, Philippe De Medina, Nadia Boubekeur, Bruno Payré, Gilles Favre, Sandrine Silvente-Poirot
Journal: Cancer Research (2006)

5551  The existence of a new metabolism in the aminosteroid series in fish was suggested, after the isolation of squalamine from the shark. Squalamine is a product of condensation of 24-sulfo-7,24 cholestane diol and spermidine in the C-3 position of the sterol. The squalamine and its analogues are currently evaluated for the treatment of small cell lung cancer, breast and ovaries cancers. We discovered the existence of such a metabolism in the mammals by identifying a new aminosteroid that we named “dendrogenine A (DA)” (World Patent 2003/089449). The aim of the present study was to characterize the biological properties of DA and to determine whether DA displays anti-tumor activity. We showed that in vitro nanomolar concentrations of DA stimulate the differentiation of monocytes into dendritic-like cells that activate the T Lymphocyte response. We have tested the antitumor activity of DA on syngenic mammary tumors (TS/A) injected subcutaneous on the flanc of normal mice and observed that DA (2.5 μg DA/ kg) can control 60% of the growth of tumors after 30 days, while such effect was not observed when similar experiment was performed on athymic mice, confirming that T Lymphocytes are important actors of the antitumor activity of DA. Because no tumor antigenes were injected, we investigated whether DA could also affect tumor cells. TS/A cells treated with DA were shown to produce multivesicular bodies in their cytoplasm and to express major histocompatibility complexes (MHC) of class II, suggesting that DA-treated cells produce tumor antigenes that are presented by MHC to T lymphocytes. Similar results were obtained on B16F10 melanoma cells treated by DA in vivo and in vitro. In conclusion, we have identified a new aminosteroid metabolite that displays a dual anti-tumor mechanism of action by activating the T lymphocyte response through its action on dendritic cells and by inducing the recognition of the tumor cells by T lymphocytes.
Differential Effect of E-Selectin Antibodies on Neutrophil Rolling and Recruitment to Inflammatory Sites
Authors: Carroll L. Ramos, Eric J. Kunkel, Michael B. Lawrence, Unsu Jung, Dietmar Vestweber, Roland Bosse, Kim W. McIntyre, Kathleen M. Gillooly, Christine R. Norton, Barry A. Wolitzky, Klaus Ley
Journal: Blood (1997)
Acute Heart Failure Syndromes in Patients With Coronary Artery Disease
Authors: James D. Flaherty, Jeroen J. Bax, Leonardo De Luca, Joseph S. Rossi, Charles J. Davidson, Gerasimos Filippatos, Peter P. Liu, Marvin A. Konstam, Barry Greenberg, Mandeep R. Mehra, Günter Breithardt, Peter S. Pang, James B. Young, Gregg C. Fonarow, Robert O. Bonow, Mihai Gheorghiade
Journal: Journal of the American College of Cardiology (2009)
SUDDEN DEATH IN RHEUMATIC FEVER
Authors: George C. Griffith, Robert W. Huntington
Journal: Annals of Internal Medicine (1946)

Article1 August 1946SUDDEN DEATH IN RHEUMATIC FEVERGEORGE C. GRIFFITH, ROBERT W. HUNTINGTON JR.GEORGE C. GRIFFITHSearch for more papers by this author, ROBERT W. HUNTINGTON JR.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-25-2-283 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptINTRODUCTIONAbrupt cessation of heart beat, as distinguished from gradual failure, involves mechanisms of which we know little.1, 2Sudden death occurring in this manner often finds no adequate pathologic explanation, although there is usually evidence of cardiac and aortic disease. In searching for a plausible general hypothesis, that of acute circulatory impairment in the heart, lungs, or brain-stem appears not unattractive. Although vascular occlusion by emboli, by thrombi forming in damaged areas, or by gradually progressing sclerosis has long engaged the attention of pathologists, awareness of functional vascular changes, in part, perhaps, referable to the autonomic nervous system3of...Bibliography1. HAMILTONROBERTSON RLH: Electrocardiographic studies of dying heart in angina pectoris, Canad. Med. Assoc. Jr., 1933, xxx, 122-124. Google Scholar2. MUNCK W: Sudden death from heart failure in adults, Ugesk. f. laeger, 1931, xciii, 787-794. Google Scholar3. HILL IG: Stimulation of vagus nerve and carotid sinus in man, Quart. Jr. Exper. Physiol., 1932, xxii, 79-93. CrossrefGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: *Received for publication November 29, 1945.From the Rheumatic Fever Unit, U. S. Naval Hospital, Corona, California. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byDie Coronarerkrankungen. Coronarinsuffizienz, Angina pectoris und HerzinfarktRHEUMATISM AND ARTHRITIS REVIEW OF AMERICAN AND ENGLISH LITERATURE OF RECENT YEARS (TENTH RHEUMATISM REVIEW)* Part IIWILLIAM D. ROBINSON, M.D., F.A.C.P., EDWARD W. BOLAND, M.D., F.A.C.P., JOSEPH J. BUNIM, M.D., F.A.C.P., DARRELL C. CRAIN, M.D., F.A.C.P., EPHRAIM P. ENGLEMAN, M.D., F.A.C.P., WALLACE GRAHAM, M.D., F.R.C.P. (C), L. MAXWELL LOCKIE, M.D., F.A.C.P., MAX M. MONTGOMERY, M.D., F.A.C.P., CHARLES RAGAN, M.D., F.A.C.P., MARIAN W. ROPES, M.D., F.A.C.P., EDWARD F. ROSENBERG, M.D., F.A.C.P., CHARLEY J. SMYTH, M.D.Architectonics of the heartStenosing Coronary ArteritisAcute myocardial infarction during a prolonged allergic reaction to penicillinDiscussion on the Management of Rheumatic Fever and its Early Complications 1 August 1946Volume 25, Issue 2Page: 283-292KeywordsCardiovascular therapyHeartHeart diseasesHeart failureLungsNervous systemPathologistsRheumatic feverSclerodermaSudden cardiac death ePublished: 1 December 2008 Issue Published: 1 August 1946 PDF downloadLoading ...
Abstract 794: The ATR inhibitor VE-821 in combination with the novel topoisomerase I inhibitor LMP-400 selectively kills cancer cells by disabling DNA replication initiation and fork elongation
Authors: Rozenn Jossé, Scott E. Martin, Rajarshi Guha, Pinar Ormanoglu, Thomas Pfister, Joel Morris, James H. Doroshow, Yves Pommier
Journal: Cancer Research (2014)

Abstract Camptothecin, a specific topoisomerase I inhibitor is a potent anticancer drug, especially against solid tumors. This agent produces well-characterized double-strand breaks upon collision of replication forks with topoisomerase I cleavage complexes. In an attempt to improve its efficacy, we conducted a synthetic lethal siRNA screening using a library that targets nearly 7000 human genes. Depletion of ATR, the main transducer of replication stress-induced DNA damage response exacerbated cytotoxic response to both camptothecin and the indenoisoquinoline LMP-400, a novel class of topoisomerase inhibitors in clinical trial. Inhibition of ATR by the recently developed specific inhibitor VE-821 induced synergistic antiproliferative activity when combined with either topoisomerase inhibitor. Cytotoxicity induced by the combination with LMP-400 was greater than with camptothecin. Using single cell analysis and DNA fiber spread, we show that VE-821 abrogated the S-phase checkpoint, restored origin firing and replication fork progression. Moreover, the combination of a topoisomerase inhibitor with VE-821 inhibited the phosphorylation of ATR and ATR-mediated Chk1 phosphorylation but strongly induced γH2AX. Single cell analysis revealed that γH2AX pattern changed overtime from well-defined focus to a pan-nuclear staining. The change in γH2AX pattern can be useful as a predictive biomarker to evaluate the efficacy of therapy. The key implication of our work is the clinical rationale it provides to evaluate the combination of indenoisoquinoline topoisomerase I inhibitors with ATR inhibitors. Citation Format: Rozenn Jossé, Scott E. Martin, Rajarshi Guha, Pinar Ormanoglu, Thomas Pfister, Joel Morris, James H. Doroshow, Yves Pommier. The ATR inhibitor VE-821 in combination with the novel topoisomerase I inhibitor LMP-400 selectively kills cancer cells by disabling DNA replication initiation and fork elongation. [abstract]. In: Proceedings of the 105th Annual Meeting of the American Association for Cancer Research; 2014 Apr 5-9; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2014;74(19 Suppl):Abstract nr 794. doi:10.1158/1538-7445.AM2014-794