THE EFFECT OF DUODENAL STIMULATION IN MAN UPON ALIMENTARY AND ADRENALIN HYPERGLYCEMIA
Authors: Harry Shay, J. Gershon-Cohen, Samuel S. Fels
Journal: Annals of Internal Medicine (1938)

Article1 March 1938THE EFFECT OF DUODENAL STIMULATION IN MAN UPON ALIMENTARY AND ADRENALIN HYPERGLYCEMIAHARRY SHAY, M.D., J. GERSHON-COHEN, M.D., D.Sc. (Med.), SAMUEL S. FELS, LL.D.HARRY SHAY, M.D.Search for more papers by this author, J. GERSHON-COHEN, M.D., D.Sc. (Med.)Search for more papers by this author, SAMUEL S. FELS, LL.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-11-9-1563 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptAs early as 1825, Leuret and Lassaigne33from studies on the horse and dog wrote that the causes which determined the secretion of pancreatic juice were analogous to those which influenced the outflow of saliva. From the application of various substances to the orifice of the pancreatic duct they concluded that weak acids, especially, caused an abundant flow of pancreatic juice. Later, in a discussion of the physiology of the intestine, they made the pertinent suggestion that the chyme, since it was constantly acid, must enjoy the same property upon its passage from the stomach into the intestines. One must...Bibliography1. BAYLISSSTARLING WMEH: The mechanism of pancreatic secretion, Jr. Physiol., 1902, xxv, 325. CrossrefGoogle Scholar2. BEAUMONT W: Experiments and observations on the gastric juice and the physiology of digestion, Plattsburgh, 1833, p. 17. Google Scholar3. BEKKER NM: De l'influence des solutions de becarbonate de soude, de sel marin, d'acide carbonique, et de quelques eaux alcalines sur la sécrétion du suc pancréatique, Arch. d. Sci. biol., 1893, ii, 433. Google Scholar4. BOATTINI G: L'Azione ipoglicemizzante dell'acido cloridrico nel diabete mellito, Minerva Med., 1931, ii, 245. Google Scholar5. CHAMBERSTHOMPSON EKKW: Quantitative changes in tissue glycogen, blood sugar, plasma, inorganic phosphates and in blood lactic acid in canine histamine shock, Jr. Infect. Dis., 1925, xxxvii, 229. CrossrefGoogle Scholar6. COEHLOOLIVEIRA EJC: Relations entre la sécrétion interne et la sécrétion externe du pancréas, Compt. rendu Soc. de biol., 1928, xcviii, 477. Google Scholar7. CONTI A: L'Azione ipoglicemizzante dell'acido cloridrico (Ricerche cliniche e sperimentali), Giorn. Med. Alto Adige, 1933, v, 241. Google Scholar8. CRIADO FG: Sobre la Secretina Pancréatical, Los Progresos de la clincia, 1928, i, 59. Google Scholar9. DALE HH: On the islets of Langerhans in the pancreas, Philos. Trans. Roy. Soc. London (Series B), 1905, cxcvii, 25. Google Scholar10. DIXONWADIA WEJH: The action of intestinal extracts, Brit. Med. Jr., 1926, i, 820. CrossrefGoogle Scholar11. DOLINSKI J: L'acide comme stimulant de la sécrétion pancréatique, Arch. d. Sci. biol., 1894, iii, 399. Google Scholar12. DUNCANSHUMWAYWILLIAMSFETTER GGNPTLF: The clinical application of duodenal extract (Macallum-Laughton) in diabetes mellitus, Am. Jr. Med. Sci., 1935, clxxxix, 403. CrossrefGoogle Scholar13. EPSTEINROSENTHALMAECHLINGDE BECK AANEHV: Studies on the relation of the external to the internal secretion of the pancreas. 1. Biochemical study of the nature of the action of trypsin on insulin, Am. Jr. Physiol., 1924, lxx, 225. CrossrefGoogle Scholar14. FIESCHI A: Ricerchi sperimentale sull'azione della secretina pancreatica, Biochim. e. Ter. Sperim., 1927, xiv, 289. Google Scholar15. FREUDSAADI-NAZIM J: Action des injections intra-duodénales d'acide sur la sécrétion interne du pancréas, Compt. rendu Soc. de biol., 1926, xcv, 571. Google Scholar16. GLEYHAZARD ER: Excitation simultanée de la sécrétion externe et de la sécrétion interne du pancréas, Compt. rendu Soc. de biol., 1928, xcix, 16. Google Scholar17. GOLDSTEIN B: Zur Physiologie des isolierten Pankreas. IV. Über die Wirkung des Sekretins auf die Adrenalin-sekretion der isolierten Nebenniere, Ztschr. f. d. ges. exper. Med., 1930, lxxiv, 134. Google Scholar18. HELLER H: Über den Blutzuckerwirksamen Stoff in Secretinextrakten, Arch. f. exper. Path. u. Pharm., 1929, cxlv, 343. CrossrefGoogle Scholar19. HELLER H: Über das blutzuckersenkende Hormon der Darmschleimhaut (Duodenin), Wien. klin. Wchnschr., 1931, xliv, 476. Google Scholar20. HELLER H: Über das Insulotrope Hormon des Darmschleimhaut (Duodenin), Arch. f. Path. u. Pharm., 1935, clxxvii, 127. Google Scholar21. HERMANN H: Sur les effets hyperglycémiants primitifs des injections de sécrétine de Bayliss-Starling, Rev. Franc. D'Endocrinologie, 1926, iv, 381. Google Scholar22. IVYFISCHER ACNF: The presence of an insulin-like substance in gastric and duodenal mucosa and its relation to gastric secretion, Am. Jr. Physiol., 1924, lxvii, 445. CrossrefGoogle Scholar23. LA BARRE J: Sur les causes des variations de la glycémie au cours des chocs, anaphylactique, histaminique et peptonique, Arch. Méd. Expér., 1927, iii, 31. Google Scholar24. LA BARRESTILL JEU: Studies on the physiology of secretion. III. Further studies on the effects of secretin on the blood sugar, Am. Jr. Physiol., 1929-30, xci, 649. Google Scholar25. LA BARRE J: Sur les possibilités d'un traitement due diabéte par l'incretine, Bull. d. l'acad. Rov. de Méd. de Belgique, 1932, xii, 620. Google Scholar26. LA BARREHOUSSA JP: Les effects des injections intraduodénales d'acide chez des chiens à portion exocrine due pancréas dégenérée, Compt. rendu Soc. de biol., 1932, cx, 598. Google Scholar27. LA BARRELEDRUT JJ: Maintien en vie de chiens totalement dépancréatés traités par les extraits duodénaux, Compt. rendu Soc. de biol., 1934, cxv, 1233. Google Scholar28. LA BARRE J: Le rôle des hormones duodénales (sécrétine) dans le métabolisme glucidique, Bull. Acad. Roy. Med. Belg., 1934, xiv, 469. Google Scholar29. LALOU S: Recherches sur quelques agents destructeurs de la sécrétine, Jr. de physiol. et de path., 1912, xiv, 465. Google Scholar30. LAMBERTHERMANN MH: Sécrétine et glycémie, Compt. rendu Soc. de biol., 1925, xcii, 440. Google Scholar31. LAUGHTONMACALLUMRABINOWITCHWATSON NBABIMEM: Further observations on the action of duodenal extract on blood sugar, Jr. Biol. Chem., 1931, xcii, xx. Google Scholar32. LAUGHTONMACALLUM NBAB: The relation of the duodenal mucosa to the internal secretion of the pancreas, Proc. Roy. Soc. London, Series B, 1932, iii, 37. Google Scholar33. LEURETLASSAIGNE FJL: Recherches physiologiques et chimiques pour servir a l'histoire de la digestion, Paris, 1825, p. 108, 140-142. Google Scholar34. LUCCHI G: Contributo allo studio dei rapporti tra secrezione interna ed esterna del pancreas, Minerva Med., 1933, xxiv, 799. Google Scholar35. MACALLUM AB: A factor in the causation of diabetes mellitus, Canad. Med. Assoc. Jr., 1929, xx, 46. Google Scholar36. MELLANBY J: Isolation of secretin; its chemical and physiological properties, Jr. Physiol., 1928, lxvi, 1. Google Scholar37. MELLANBY J: Secretin, Proc. Roy. Soc. London, B. III, 1932, 429. Google Scholar38. MICHELAZZI AM: L'azione dell'acido cloridrico sulla glicemia negli epatici. II. Policlinico (Sezione Medica), 1934, xii, 78. Google Scholar39. OEHMEWIMMERS CK: Wirkung von Duodenalschleimhaut Extrakten (Secretin) auf den Blutzucker, Ztschr. f. d. ges. exper. Med., 1923, xxxviii, 1. CrossrefGoogle Scholar40. PARSONS E: Histamine as a constituent of secretin preparations, Am. Jr. Physiol., 1925, lxxi, 479. CrossrefGoogle Scholar41. PENAUSIMONNET HH: Sécrétine duodénale et insuline, Bull. Soc. de Chimie Biol., 1925, vii, 18. Google Scholar42. PENAUSIMONNET HH: La sécrétine, Revue Méd. Chir. des Maladies du Foie, du Pancréas et de la Rate, 1926, i, 64. Google Scholar43. PROUT W: On the nature of the acid and saline matter usually existing in the stomach of animals, Philos. Trans. London, 1824, pp. 45-49. Google Scholar44. RAVDINJOHNSTONMORRISON ISCGPJ: Comparison of concentration of glucose in the stomach and intestine after intragastric administration, Proc. Soc. Exper. Biol. and Med., 1933, xxx, 955. CrossrefGoogle Scholar45. SANTOS RN: L'action hypoglycémiante de la sécrétine duodénale, Bull. Soc. de Chimie Biol., 1925, vii, 1151. Google Scholar46. SANTOS RN: The effect of duodenal secretin upon the secretion of insulin by the pancreas, Endocrinology, 1928, xii, 199. CrossrefGoogle Scholar47. SANTOS RN: Secretina e insulina, Arch. de Med. Cir. Y. Espec., 1929, xxx, 493. Google Scholar48. SHAYGERSHON-COHEN HJ: Experimental studies in gastric physiology in man. II. A study of pyloric control; the rôles of acid and alkali, Surg., Gynec. and Obst., 1934, lviii, 935. Google Scholar49. SPRIGGS E: Quoted by FOSTER N. B.: Cases of diabetes treated with secretin, Jr. Biol. Chem., 1906, ii, 297. Google Scholar50. STILLSHPINER EULB: Studies on the physiology of secretin. II. The effect of purified secretion on the blood sugar, Am. Jr. Physiol., 1929-30, xci, 496. Google Scholar51. STILL EU: Secretion, Physiol. Rev., 1931, xi, 428. Google Scholar52. TAKACS L: Versuche mit Secretin. 1. Blutzuckervermindernde Wirkung des Secretins bei Tierexperimenten, Ztschr. f. d. ges. exper. Med., 1927, lvii. Google Scholar53. TROTEANO VC: Recherches expérimentales sur les variations de la glycémie déterminée par la sécrétine, Compt. rendu Soc. de biol., 1924, xci, 1368. Google Scholar54. USUELLI F: Correlazioni fra funzione esocrina e funzione endocrina del fegato, Atti della Società Lombarda di Scienze Mediche e Biologische, 1927, xvi, 171. Google Scholar55. WORKMAN C: Quoted in reference 32. Google Scholar56. ZUNZLA BARRE EJ: Relations entre les sécrétion externe et interne du pancréas, Bull. L'acad. Roy. de Belg., 1928, viii, 801. Google Scholar57. ZUNZLA BARRE EJ: Sur les causes de l'hyperinsulinémie consécutive a l'injection intraveineuse de solution de sécrétine non-hypotensive, Compt. rendu Soc. de biol., 1928, xcix, 335. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Philadelphia, Pennsylvania*Received for publication June 16, 1937.From the Samuel S. Fels Research Fund and the Gastro-Intestinal Division of Medical Service—I. Mt. Sinai Hospital, Philadelphia, Pa. Nextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byRelease of Gastric Inhibitory Polypeptide (GIP) by Intraduodenal Acidification in Rats and Humans and Abolishment of the Incretin Effect of Acid by GIP-Antiserum in RatsThe incretin concept todayEffects of coffee ingestion on oral glucose tolerance curves in normal human subjectsCONGENITAL WORD BLINDNESSHormones of the Gastrointestinal TractGastric anacidity: Its physiologic and clinical significance and its managementThe absorption and dilution of glucose solutions in the human stomach and duodenumThe absorption of hydrochloric acid by the human stomach 1 March 1938Volume 11, Issue 9Page: 1563-1589KeywordsAcidsGastroenterology and hepatologyHyperglycemiaPancreatic ductsResearch fundingSalivaStomach ePublished: 1 December 2008 Issue Published: 1 March 1938 Copyright & PermissionsCopyright, 1938, by The American College of PhysiciansPDF downloadLoading ...