Penicillin-Associated Interstitial Nephritis
Authors: ROBERT B. COLVIN
Journal: Annals of Internal Medicine (1974)

Letters1 September 1974Penicillin-Associated Interstitial NephritisROBERT B. COLVIN, M.D., JOHN R. BURTON, M.D., NEWTON E. HYSLOP JR., M.D., LAWRENCE SPITZ, M.D., NORMAN S. LICHTENSTEIN, M.D.ROBERT B. COLVIN, M.D.Search for more papers by this author, JOHN R. BURTON, M.D.Search for more papers by this author, NEWTON E. HYSLOP JR., M.D.Search for more papers by this author, LAWRENCE SPITZ, M.D.Search for more papers by this author, NORMAN S. LICHTENSTEIN, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-81-3-404 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: Interstitial nephritis is a rare, but clinically significant, complication of therapy with penicillin and related drugs (1, 2). The immunopathologic features of this unusual response have been described in but a single, well-studied methicillin case (1). We report here a case of interstitial nephritis associated with penicillin G therapy that substantially confirms previous findings and provides further information.A 70-year-old man with normal renal function (creatinine level, 0.9 mg/100 ml) became afebrile while receiving 20 X 106units/day of penicillin G intravenously for viridans streptococcus endocarditis. In the fourth week of therapy he developed low-grade fever, eosinophilia,...References1. BALDWINLEVINEMCCLUSKEY DBR: Renal failure and interstitial nephritis due to penicillin and methicillin. N Engl J Med 279:1245-1252, 1968 CrossrefMedlineGoogle Scholar2. BURTONLICHTENSTEINCOLVIN JNR: Acute interstitial nephritis from oxacillin. Hopkins Med J 134:58-61, 1974 MedlineGoogle Scholar3. COLVINJOHNSONMIHM RRM: Role of the clotting system in cell-mediated hypersensitivity. I. Fibrin deposition in delayed skin reactions in man. J Exp Med 138:686-698, 1973 CrossrefMedlineGoogle Scholar4. KARCHMERHYSLOPDISMUKES ANW: Specificity of antipenicilloyl antibodies: utility in radioimmunassay of penicillins. Clin Res 20:531, 1972 Google Scholar5. DVORAKSIMPSONFLAX HBM: The fate of antigen in delayed hypersensitivity skin reactions. J Immunol 104:718-727, 1970 MedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Departments of Pathology and Medicine Massachusetts General Hospital Harvard Medical School Boston, Massachusetts 02114 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByDrug-Induced Acute Interstitial NephritisAcute Interstitial NephritisPenicillin G-induced Hemorrhagic Cystitis with HydronephrosisImmunological Mechanisms of Interstitial DiseaseImmunologically-mediated toxin-induced renal diseasesCloxacillin-Induced Acute Tubulo Interstitial NephritisDrug-Induced Renal DisordersEnzymuria as an Indicator of Renal PathomorphologyReview: Acute tubulointerstitial nephritisInterstitial NephritisPathogenesis and therapy of interstitial nephritisImmunologically Mediated Nephritis Induced by Toxins and DrugsIncidence of renal diseases in a geriatric unitNephrotoxic Tubular and Interstitial Lesions: Morphology and ClassificationHypersensitivity Phenomena and the Kidney: Role of Drugs and Environmental AgentsPenicillin Allergy ? Can the Incidence be Reduced?Different Forms of Ischemic/ Toxic Acute Renal Failure in HumansCase 42-1983Toxicology of β-Lactam AntibioticsPenicillins and CephalosporinsImmunologically mediated lesions of kidney tubules and interstitium in laboratory animals and in manEFFECT OF STORAGE OF PENICILLIN-G SOLUTIONS ON SENSITISATION TO PENICILLIN-G AFTER INTRAVENOUS ADMINISTRATIONImmunopathology of Tubulo-Interstitial Nephritis in Man and in Experimental AnimalsSTRUCTURE SIDE-EFFECT SORTING OF DRUGS.Drug-Associated NephropathyIN-VITRO BASOPHIL DEGRANULATION IN DRUG-SUSPECTED ACUTE RENAL FAILURETHYROID HEART-DISEASEThe Nephrotoxicity of Antimicrobial AgentsMethicillin-Associated Nephritis: Clinical Rarity or Common Entity?Case 49-1975Basophilic Leucocytes: Structure, Function and Role in Disease 1 September 1974Volume 81, Issue 3Page: 404-405KeywordsCreatinineDrug therapyEndocarditisEosinophiliaFeversHyperthermiaNephritisPenicillinStreptococcus Issue Published: 1 September 1974 PDF DownloadLoading ...