tbuckley/cabot-search huggingface dataset:
Abstract P005: Association Between County Elementary and Secondary Educational Policy With Cardiovascular Health
Authors: Adam Christian, Courtney Pilkerton, Sarah Singh, Thomas K Bias, Stephanie J Frisbee
Journal: Circulation (2015)

BACKGROUND: Recent research recognizing the socioeconomic influence of educational attainment on population health, including cardiovascular health (CVH), suggests that modifying educational policy to improve educational outcomes could be an effective approach to improving health outcomes. Although the positive association of educational level with health status is well documented, the effect of education policy on health outcomes is not as thoroughly studied. Identifying relationships amongst educational policy and CVH could provide a target for public policy initiatives designed to positively impact population health. OBJECTIVE: The objective was to examine the potential effect of varying county educational policy on county and individual CVH outcomes. METHODS: Variables of county educational policy were expenditures per pupil, percent of total revenue from each state and local sources, and pupil teacher ratios. School district data from 1997-2005 sourced from the National Center for Education Statistics were adjusted for inflation using the U.S. Dept. of Labor Consumer Price Index as well as regional cost differences using the NCES Comparable Wage Index by school district, and grouped by county. County and individual CVH for 2011 was scored using the AHA’s CVH metric and data from the Behavioral Risk Factor Surveillance System. Linear regression models were used to compare the county means for each education policy variable with both county and individual CVH scores. RESULTS: Mean percent revenue from local sources and mean pupil teacher ratio were both shown to be positively associated with county level CVH (p=0.007 and p=0.023). Individual CVH was inversely associated with mean expenditures per pupil (p=0.023), and positively associated with mean percent revenue from local (p&lt;0.01), mean percent revenue from state (p&lt;0.01), and mean pupil teacher ratio (p&lt;0.001). There was an interactive effect between mean expenditure per pupil and county urbanicity on county CVH (p&lt;0.05), which differed in rural counties compared to the most urban. There was also an interactive effect between mean percent revenue from local and county urbanicity on county CVH (p&lt;0.001). Although no significant effect was observed for mean expenditures per pupil on county CVH, mean expenditures per pupil was inversely related to county CVH in the most urban counties (b=-3.58e-06), and positively related to county CVH in most rural counties (b=4.62e-06). Evidence of relationships between county educational policies and resources with CVH suggests the need for continued research more thoroughly examining variables of education policy as indicators for CVH. CONCLUSION: Further clarification of these relationships will help determine if educational policy adjustments driven by health improvement initiatives would be a useful addition to current strategies aimed at improving population health.
c-Cbl Is Tyrosine-Phosphorylated by Interleukin-4 and Enhances Mitogenic and Survival Signals of Interleukin-4 Receptor by Linking With the Phosphatidylinositol 3′-Kinase Pathway
Authors: Hiroo Ueno, Ko Sasaki, Hiroaki Honda, Tetsuya Nakamoto, Tetsuya Yamagata, Kiyoshi Miyagawa, Kinuko Mitani, Yoshio Yazaki, Hisamaru Hirai
Journal: Blood (1998)
Intensive ALL-type therapy without local radiotherapy provides a 90% event-free survival for children with T-cell lymphoblastic lymphoma: a BFM group report.
Authors: Alfred Reiter, Martin Schrappe, Wolf-Dieter Ludwig, Markus Tiemann, Reza Parwaresch, Martin Zimmermann, Eckard Schirg, Günter Henze, Günther Schellong, Helmut Gadner, Hansjörg Riehm
Journal: Blood (2000)
A shotgun optical map of the entire Plasmodium falciparum genome
Authors: Zhongwu Lai, Junping Jing, Christopher Aston, Virginia Clarke, Jennifer Apodaca, Eileen T. Dimalanta, Daniel J. Carucci, Malcolm J. Gardner, Bud Mishra, Thomas S. Anantharaman, Salvatore Paxia, Stephen L. Hoffman, J. Craig Venter, Edward J. Huff, David C. Schwartz
Journal: Nature Genetics (1999)
Novel murine xenograft models of human osteosarcoma and in vivo response to gemcitabine, L-alanosine, and herceptin
Authors: E. Anders Kolb, Bethanne Wenzel, Pamela Merola, Rui Yang, Rebecca Sowers, Peter G. Steinherz, John Healey, Andrew G. Huvos, Paul A. Meyers, Richard Gorlick
Journal: Cancer Research (2004)

5131   Osteosarcoma (OS) is the most common primary malignant tumor of bone in children and young adults. It has a high propensity to metastasize to the lungs, liver, and bone. In fact, death from lung metastases will occur in 30% of OS patients. Nonetheless there are few good  in vivo  models of human osteosarcoma that can be utilized for the identification of new therapies. Between 1996 and 2003 we collected 230 osteosarcoma samples from pediatric patients at the time of diagnosis, definitive surgery, or relapse. All samples were disaggregated and placed in culture. Tumors that were successfully cultured, were subsequently injected into SCID mice. Twenty cultured and 8 xenograft lines were derived. Heterotopic flank models and orthotopic lung and tibia models are described. The xenograft lines have been characterized for  in vivo  response to a variety of chemotherapeutic agents, and these responses correlated to the molecular characteristics of the tumors. Treatment groups consisted of 5 to 8 mice, and each animal received treatment with either drug or normal saline when tumors reached a volume of 1cm 3 . Tumor measurements were taken at the completion of 1 week of therapy. Mice treated with twice weekly gemcitabine (60mg/kg/dose) had tumors of 0.2cm 3  versus the controls of 2.2cm 3 . Mice bearing tumors with a deletion in MTAP (responsible for the salvage of adenine back into the adenylate pool) were treated with L-alanosine (an inhibitor of de novo adenylate synthesis) and their response compared to mice with MTAP intact tumors. After one week of L-alanosine, MTAP-deleted tumors were significantly smaller (1.2cm 3 , standard deviation 0.9) than controls (7.0cm 3 , standard deviation 2.4, p 3  versus 1.8cm 3 ). We describe 8 novel xenograft models of human osteosarcoma and demonstrate that the molecular characteristics of these lines predict  in vivo  response to chemotherapeutics.
1027. A 4-Week Safety Study of Reolysin® Administered by Daily Intravenous Infusion to Cynomolgus Monkeys, with a 4-Week Recovery Period
Authors: Ken Draper, Lydia Andrews-Jones, Jeremy Evans, Matthew C. Coffey, Brad Thompson
Journal: Molecular Therapy (2004)

Reovirus (Reolysin®) is a viral entity that replicates only in cells expressing an activated Ras pathway, and as such, this virus represents a novel therapy for cancer. In anticipation of systemic application of Reolysin® to humans, this study evaluated the safety of Reolysin® administration (via 15-minute intravenous infusion) to cynomolgus monkeys at daily dose levels of 0, 5.0 × 107, 5.0 × 108, and 5.0 × 109 TCID50 for 28 consecutive days. In-life, monkeys were evaluated for clinical signs of effect, and changes in food consumption, body weight, electrocardiographic and ophthalmic measurements, and serum chemistry, hematology, and coagulation parameters. A subset of monkeys underwent scheduled euthanasia on Day 29, and the remaining monkeys were maintained for an additional treatment-free 28-day period to evaluate reversibility of Reolysin®-related changes. At euthanasia, a full necropsy was conducted on all monkeys, urine samples were obtained via bladder puncture and analyzed, selected organ weights were recorded, and tissues were collected, preserved, processed and examined using light microscopy.
Challenges of Using Peri-procedural Myocardial Infarction as a Quality Measure Among Patients Undergoing Percutaneous Coronary Intervention
Authors: Tracy Y Wang
Journal: Circulation (2007)

Abstract 1754 Tracy Y Wang, David Dai, Eric D Peterson, Sunil V Rao, Matthew T Roe, Duke University, Durham, NC; on behalf of the National Cardiovascular Data Registry Tracy Y Wang, 2007 Finalist and Presenting Author
Treatment of Recurrent Erysipelas
Authors: Harold L. Amoss
Journal: Annals of Internal Medicine (1931)

Article1 October 1931Treatment of Recurrent ErysipelasHAROLD L. AMOSS, M.D., F.A.C.P.HAROLD L. AMOSS, M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-5-4-500 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptRecrudescences and relapses are not uncommon in streptococcal infections. In facial erysipelas, the lesion may subside and the skin become almost normal but suddenly within a few hours all the signs and symptoms may return. When this occurs in facial erysipelas we have learned to suspect the presence of sinusitis. An example will illustrate this type of recrudescence:Italian girl, aged sixteen years, admitted on the sixth day of an erysipelas infection involving both sides of the face, marked cervical adenitis and pharyngitis with obstruction to breathing. There was tenderness over both maxillary sinuses.The symptoms of toxemia disappeared quickly... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Durham, N. C.*Presented at the Baltimore Meeting of the American College of Physicians, March 25, 1931. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byPulmonary fibrosis in rheumatic heart disease 1 October 1931Volume 5, Issue 4Page: 500-504KeywordsBreathingLesionsPharyngitisSigns and symptomsStreptococcal infections ePublished: 1 December 2008 Issue Published: 1 October 1931 PDF downloadLoading ...
Lead aVR, a mostly ignored but very valuable lead in clinical electrocardiography**Editorials published in the Journal of the American College of Cardiologyreflect the views of the authors and do not necessarily represent the views of JACCor the American College of Cardiology.
Authors: Anton P.M. Gorgels, D.J.M. Engelen, Hein J.J. Wellens
Journal: Journal of the American College of Cardiology (2001)
A STUDY OF 118 READMISSIONS TO OAKHURST SANATORIUM OF GRAYS HARBOR COUNTY, WASHINGTON
Authors: Howard L. Hull
Journal: Annals of Internal Medicine (1935)

Article1 August 1935A STUDY OF 118 READMISSIONS TO OAKHURST SANATORIUM OF GRAYS HARBOR COUNTY, WASHINGTONHOWARD L. HULL, M.D., F.A.C.P.HOWARD L. HULL, M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-9-2-134 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptEvery tuberculosis sanatorium, especially if it is tax supported, has its more or less large quota of readmissions, and yet one does not often see in medical literature studies of such statistics with efforts to account for relapses or other conditions requiring readmission. A careful consideration of such data by the staff of each sanatorium should yield valuable information and in time might help to correct some of the inherent difficulties.The present statistics relate to Oakhurst Sanatorium at Elma, Grays Harbor County in the State of Washington. The institution is owned and maintained by the county which has an... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Yakima, Washington*Received for publication November 15, 1934.†Formerly Medical Director of Oakhurst Sanatorium. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 August 1935Volume 9, Issue 2Page: 134-142KeywordsTaxes ePublished: 1 December 2008 Issue Published: 1 August 1935 PDF downloadLoading ...
THE SYNDROME OF PSOAS MYOSITIS AND FIBROSITIS; ITS MANIFESTATIONS AND ITS SIGNIFICANCE IN THE DIFFERENTIAL DIAGNOSIS OF LOWER ABDOMINAL PAIN
Authors: James A. Greene
Journal: Annals of Internal Medicine (1945)

Article1 July 1945THE SYNDROME OF PSOAS MYOSITIS AND FIBROSITIS; ITS MANIFESTATIONS AND ITS SIGNIFICANCE IN THE DIFFERENTIAL DIAGNOSIS OF LOWER ABDOMINAL PAINJAMES A. GREENE, M.D., F.A.C.P.JAMES A. GREENE, M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-23-1-30 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptPain and tenderness in the psoas muscle which is probably attributable to myositis or fibrositis has been known for many years, but its importance in the differential diagnosis of lower abdominal disease has not been emphasized sufficiently. During the past few years I have observed this syndrome in over 50 cases varying in age from 16 to 60 years. It has been mistaken for other diseases in most instances. In 25 of the 50 cases abdominal operations have been performed alone or in conjunction with perineal repair because of mistaken diagnosis. In addition, many of these patients have become extremely... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Houston, Texas*Received for publication December 11, 1944.From the Department of Internal Medicine, Baylor University, College of Medicine, Houston, Texas. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byAbdominal Pain 1 July 1945Volume 23, Issue 1Page: 30-34KeywordsAbdominal painFibromyalgiaMusclesMyalgiaMyositis ePublished: 1 December 2008 Issue Published: 1 July 1945 PDF downloadLoading ...
Factors predicting drop‐out in community mental health centres
Authors: BLANCA RENESES, ELENA MUÑOZ, JUAN JOSÉ LÓPEZ‐IBOR
Journal: World Psychiatry (2009)

This study aimed to identify treatment, therapist and patient factors associated with dropping out of treatment in four outpatient mental health services. The experimental group comprised all 789 individuals who attended for the first time the mental health services during one year and dropped out of treatment in the same year or during the two following ones. The control group consisted of the same number of individuals, chosen at random from patients who, in the same year, attended for the first time the services and did not subsequently drop out of treatment. The overall drop-out rate was 33.2%. According to logistic regression analysis, the predictive factors of dropping out were: being treated in a particular centre, the involvement of more than one therapist in treatment, having no previous history of psychiatric disorders, being young and being male.
Longitudinal oncology registry of head and neck carcinoma (LORHAN): Initial treatment findings
Authors: W. J. Curran, A. Chen, A. Garden, P. Harari, B. A. Murphy, S. J. Wong, L. Bellm, M. Schwartz, D. Dawson, K. Ang
Journal: Journal of Clinical Oncology (2008)

6054 Background: Registries can be invaluable for describing patterns of care for a population of patients. Most cancer registries, however, do not possess sufficient breadth or depth to provide a complete and reliable picture of clinical practice. We report the initial treatment findings of LORHAN, a new, prospective, longitudinal, observational national registry of head and neck carcinoma (HNC) patients. Methods: Patients with newly diagnosed HNC, scheduled to receive radiotherapy or drug therapy, 18 years of age or older and providing written informed consent are being enrolled. Patients participating in clinical trials are eligible for LORHAN. Patient data are entered in the registry from the time of initial diagnosis and through follow-up for a minimum of 2 years and up to 10. Detailed information on initial treatment and re-treatment is collected. Both community and academic investigators are participating in LORHAN. Results: LORHAN was launched in October 2005 and as of December 2007, 1,277 patients have been enrolled. Of these, 640 have completed initial treatment and are the subject of this report. Most (98%) have locoregional disease. The treatment data for these patients are shown in the Table. 162 patients (36%) required dose reductions at some point during initial treatment. Conclusion: LORHAN is a new national initiative that may further the understanding of the pattern of care of HNC patients across practice settings. Further follow up will generate toxicity profiles and outcome data. Initial Treatment Received All N=640 Academic n=464 Community n=176 p Value Radiotherapy (RT) alone 129 (20%) 92 (20%) 37 (21%) .74 Concurrent chemoradiation (CRT) 217 (34%) 156 (34%) 61 (35%) .80 Surgery followed by CRT 105 (16%) 84 (18%) 21 (12%) .06 Induction chemotherapy followed by CRT 74 (12%) 53 (11%) 21 (12%) .86 Surgery followed by RT 59 (9%) 43 (9%) 16 (9%) .95 Chemotherapy alone 15 (2%) 8 (2%) 7 (4%) .09 Other 16 (3%) 12 (3%) 4 (2%) .82 Most Common Drug Regimens All N=448 Academic n=326 Community n=122 p Value Cisplatin 219 (49%) 169 (52%) 50 (41%) .04 Cetuximab 82 (18%) 56 (17%) 26 (21%) .31 Carboplatin, paclitaxel 38 (9%) 27 (8%) 11 (9%) .80 Docetaxel, cisplatin, 5-FU 21 (5%) 8 (3%) 13 (11%) .0003 Other 78 (17%) 57 (18%) 21 (17%) .95 Author Disclosure Employment or Leadership Consultant or Advisory Role Stock Ownership Honoraria Research Expert Testimony Other Remuneration ImClone Bristol-Myers Squibb, ImClone, sanofi-aventis ImClone Bristol-Myers Squibb, ImClone, sanofi-aventis ImClone, Roche
Abstract 4706: Perfusion Stress Echocardiography with Perflubutane Polymer Microspheres Provides Incremental Predictive Value for Coronary Artery Disease Over Clinical Risk Factors
Authors: Asli Memisoglu, Janet Wittes, Ami E Iskandrian, Sanjiv Kaul, Thomas R Porter, Roxy Senior, Mark J Monaghan, James E Udelson, Richard C Walovitch, Michael H Picard
Journal: Circulation (2008)

Introduction RAMP (Realtime Assessment of Myocardial Perfusion Imaging) 1 and 2 showed that coronary artery disease (CAD) diagnosis with perfusion stress echocardiography (PSE) and perflubutane polymer microspheres in chest pain patients is as accurate as SPECT perfusion imaging. Hypothesis PSE provides incremental predictive value over clinical risk factors and ECG for CAD presence. Methods RAMP analysis population (n=488; mean age 62 years) included chest pain patients who underwent PSE (real-time and triggered) and gated 99m Tc SPECT at rest and with dipyridamole stress and had known CAD status by angiography (≥70% stenosis). Severe CAD was defined as &gt;40% left ventricular mass at risk of infarction (jeopardy score). Independent blinded readers (6 PSE, 4 SPECT) interpreted images for the presence of defects (wall motion and/or perfusion). Majority PSE and SPECT assessment was evaluated for CAD association using logistic regression. Covariates included resting ECG and risk factors: age, gender, smoking, diabetes, hypertension, and angina type (typical or unstable). Results Three hundred (61%) patients had CAD. In multivariate analyses adjusted for known clinical risk factors and ECG, positive PSE and SPECT were significant predictors of CAD (odds ratio (95% CI)=5.7 (3.7–8.7) and 3.6 (2.4–5.4)), respectively. PSE and SPECT added incremental value for prediction of CAD in multivariate models already including clinical factors and ECG (Table 1 ). Among patients with severe CAD (n=80), clinical factors and ECG predicted only 68% CAD prevalence compared to 83% and 79% predicted by clinical factors, ECG and either positive PSE or SPECT, respectively (p&lt;0.001). Conclusion PSE with perflubutane polymer microspheres significantly increases the probability of correct CAD diagnosis in stable chest pain patients beyond the probability established by risk factors, symptoms and ECG. Table 1 : Incremental Predictive Value of ECG, PSE and SPECT over Clinical Factors
Abstract 135: Impacts of Rewarming Speed Differences on Outcomes of Therapeutic Hypothermia in Out-of-Hospital Cardiac Arrest: an Analysis in J-Pulse Hypo-Registry, a Multicenter Hypothermia Registry in Japan
Authors: Nobuaki Kokubu, Mamoru Hase, Kazufumi Tsuchihashi, Shinya Shimoshige, Tetsuji Miura, Yasufumi Asai, Naohiro Yonemoto, Hiroyuki Yokoyama, Ken Nagao, Hiroshi Nonogi
Journal: Circulation (2010)

Background:  Although it has been reported that therapeutic hypothermia (TH) improves neurological outcomes of patients with out-of-hospital cardiac arrest, procedures of TH remain to be established. Particularly rewarming speed that maximizes protection afforded by TH has not been identified.   Methods:  Five years (2005–2009) data from the 452 patients treated with TH in the multicenter registry in Japan (J-Pulse-Hypo registry) were available, for the purpose to investigate the efficacy of TH in out-of-hospital cardiac arrest patients. Selection of cooling procedure, target body temperatures, cooling duration, and rewarming speed were left to each institution. Four hundred twenty-nine patients completed TH were retrospectively divided into the three groups according to rewarming speed: 129 patients with rewarming speed ≥ 2.0 degrees C/day (fast, F group), 188 patients with rewarming speed 1.0–1.9 degrees C /day (moderate, M group), and 118 patients with rewarming speed    Results:  In baseline characteristics, there were no significant inter-group differences in gender, age, the presence of bystanders, rate of bystander cardiopulmonary resuscitation, rate of return of spontaneous circulation before admission, target temperature and mean cooling duration, but S group had a lower frequency of ventricular fibrillation in initial ECG and a lower incidence of complication during hypothermia compared with the other 2 group. The 30-day mortality of M group was significantly lower than that of the other groups (23.0% for F, 12.3% for M, 17.8% for S, p=0.036). There were no significant difference in FNO rate between 3 groups (59.4% for F, 56.4% for M, 56.8% for S, p=0.87).   Conclusions:  The results suggest that FNO of patients treated with TH might be not affected by rewarming speed, but faster or slower rewarming might cause increase of the mortality.
The parasympathetic neuroeffector junction of the heart.
Authors: K Löffelholz, A J Pappano
Journal: Pharmacological Reviews (1985)

This review has directed attention to the anatomical, biochemical, physiological, and pharmacological features of cardiac parasympathetic neuroeffector transmission. The relationships among these properties have permitted a synthesis of the operation of the parasympathetic nervous system at the subcellular, cellular, tissue, and organ level in the heart. However, the attempt to obtain a comprehensive model of parasympathetic neuroeffector transmission in the heart has not only unmasked many features of junctional activity that are poorly understood, but also indicated significant gaps between in vitro and in vivo experimental situations.
Re-prescription of penicillin in patients who have had allergic-like reactions*1Investigation using a large electronic medical record
Authors: A.J. Apter, J.L. Kinman, W.B. Bilker, M. Herlim, D.J. Margolis, E. Lautenbach, S. Hennessy, B.L. Strom
Journal: Journal of Allergy and Clinical Immunology (2004)