tbuckley/cabot-search huggingface dataset:
Influence of Infarct-Zone Viability on Left Ventricular Remodeling After Acute Myocardial Infarction
Authors: Leonardo Bolognese, Giampaolo Cerisano, Piergiovanni Buonamici, Alberto Santini, Giovanni M. Santoro, David Antoniucci, Pier Filippo Fazzini
Journal: Circulation (1997)

The relation between residual myocardial viability after acute myocardial infarction (AMI) and ventricular remodeling has yet to be fully elucidated. We hypothesized that the presence of residual viability would favorably influence left ventricular remodeling after AMI and that serial changes in left ventricular dimensions might be related to the extent of myocardial viability in the infarct zone.Ninety-three patients with a first AMI successfully treated with primary coronary angioplasty underwent two-dimensional echocardiography within 24 hours of admission and low-dose dobutamine echocardiography at a mean of 3 days after AMI. Two-dimensional echocardiography and coronary angiography were obtained in all patients 1 and 6 months after coronary angioplasty. On the basis of dobutamine echocardiography responses, patients were divided in two subsets: those with (n=48; group I) and those without (n=45; group II) infarct-zone viability. There was no difference in minimal lesion diameter and infarct-related artery patency at 1 and 6 months between the two groups. Group II patients had significantly greater end-diastolic (76+/-18 versus 53+/-14 mL/m2; P<.0003) and end-systolic (42+/-17 versus 22+/-11 mL/m2; P<.0003) volumes at 6 months than did patients in group 1. The extent of infarct-zone viability was significantly inversely correlated with percent changes in end-diastolic volumes at 6 months (r=-.66; P<.000001) and was the most powerful independent predictor of late left ventricular dilation.After reperfused AMI, the degree of left ventricular dilation, when it occurs, is inversely related to the extent of residual myocardial viability in the infarct zone. Thus, the absence of residual infarct-zone viability discriminates patients who develop progressive left ventricular dilation after reperfused AMI from those who maintain normal left ventricular geometry.
Gastritis cystica profunda in a patient with no history of gastric surgery
Authors: D. Béchade, J. Desramé, J.P. Algayres
Journal: Endoscopy (2007)

A 79-year-old woman was admitted because of intermittent epigastric pain. She had no history of gastrectomy or gastroenterostomy. Gastroscopy revealed giant gastric folds along the anterior wall of the fundus (Figure [1]). A partial mucosectomy of the lesion showed dilated cystic glands in the basal portion of mucosa, extending to the submucosa through an interruption of the muscularis mucosae (Figure [2]). No dysplastic changes were observed. Contrast-enhanced abdominal computed tomography revealed an intraluminal polypoid mass with a thick peripheral wall (Figure [3]). Endoscopic ultrasound showed a thickened, echo-poor submucosal layer containing multiple anechogenic areas, indicating the presence of submucosal cysts (Figure [4]). These findings were consistent with gastritis cystica profunda. Because of the age of the patient, no surgical resection was performed. A follow-up gastroscopy 3 months after the initial examination showed no macroscopic changes.
Normalization of plasma lipoprotein concentrations in patients with type II hyperlipoproteinemia by combined use of neomycin and niacin.
Authors: J M Hoeg, M B Maher, E Bou, L A Zech, K R Bailey, R E Gregg, D L Sprecher, J K Susser, A M Pikus, H B Brewer
Journal: Circulation (1984)

The oral administration of neomycin or niacin as single-drug therapy can significantly lower total and low-density lipoprotein cholesterol concentrations in patients with type II hyperlipoproteinemia. However, in the majority of patients treated with one of these drugs as sole therapy plasma lipid and lipoprotein concentrations do not normalize. The effect of combined neomycin (2 g/day) and niacin (3 g/day) treatment on the plasma lipoprotein concentrations was determined in 25 type II hyperlipoproteinemic patients in a double-blind, randomized, placebo-controlled, crossover clinical trial. Treatment with neomycin was well tolerated by all 25 study patients and significantly reduced total and low-density lipoprotein cholesterol concentrations by 23% and 29%, respectively (p less than .05). In contrast to the well-tolerated neomycin regimen, 11 patients (44%) were unable to continue niacin treatment because of adverse side effects. In the 14 patients treated with both neomycin and niacin, niacin further lowered the concentrations of total and low-density lipoprotein cholesterol by 18% and 25%, respectively, and increased high-density lipoprotein cholesterol by 32% (p less than .05) compared with that in the patients receiving neomycin plus niacin placebo. Compared with diet-only therapy, combined treatment with neomycin plus niacin reduced the total plasma cholesterol concentration by 36%, low-density lipoprotein cholesterol by 45%, and the low-density lipoprotein/high-density lipoprotein ratio by 46% and it increased plasma high-density lipoprotein concentrations by 24% (p less than .001). During the study, 80% of all the study patients and 92% of the patients who complied with the combined regimen normalized their total and low-density lipoprotein concentrations.(ABSTRACT TRUNCATED AT 250 WORDS)
Four-year to Eight-year Results of Vagotomy and Simple Drainage for Benign Lesser Curve Gastric Ulcer
Authors: H. Burge, A. M. Gill, C. Maclean, R. Stedeford
Journal: BMJ (1970)

The results of vagotomy and simple drainage for recurrent benign lesser curve gastric ulcer are recorded. Seventy-two consecutive cases were treated from 1962 to 1965. The follow-up is therefore from five to eight years. In only two cases did the ulcer fail to heal and remain healed. Four years after operation both these had persistent ulceration and persistent gastric retention. Both have apparently been cured by gastrojejunostomy done to improve gastric drainage.
Ruptured Chordae Tendineae: Clinical Experience and Treatments.
Authors: Ralph L. Brandt
Journal: Annals of Internal Medicine (1965)

s1 May 1965Ruptured Chordae Tendineae: Clinical Experience and Treatments.Ralph L. Brandt, M.D., F.A.C.P., Joe O. Morris, M.D., Craig R. Barlow, M.D. (Associate)Ralph L. Brandt, M.D., F.A.C.P.Search for more papers by this author, Joe O. Morris, M.D.Search for more papers by this author, Craig R. Barlow, M.D. (Associate)Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-62-5-1073_2 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptRupture of chordae tendinae probably occurs more frequently than has been realized. This entity was found to be the mechanism of mitral regurgitation in 14 out of 64 patients operated upon for mitral valve insufficiency, a frequency of 22%. Coronary heart disease has been sited as a cause of rupture of papillary muscles but not chordae tendinae. The lesion in eight patients, mean age was 41, was of rheumatic etiology. In the nonrheumatic group of six patients, mean age was 58, coronary heart disease was present in four with electrocardiographic evidence of posterior myocardial infarction in three. Hypertension was recorded... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Ann Arbor, Michigan PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 May 1965Volume 62, Issue 5Page: 1073-1073KeywordsCoronary heart diseaseElectrocardiographyEtiologyHypertensionLesionsMitral insufficiencyMyocardial infarctionPapillary muscles Issue Published: 1 May 1965 PDF downloadLoading ...
TCT-161 Transcatheter Closure of Atrial Septal Defect with Inferior Vena Cava Rim Deficiency: Reconsideration of anatomical indication
Authors: Teiji Akagi, Yasufumi Kijima, Koji Nakagawa, Yoichi Takaya, Hiroki Oe, Hiroshi Ito, Shunji Sano
Journal: Journal of the American College of Cardiology (2014)
Emergency patients in England wait longer to be seen
Authors: A. Cole
Journal: BMJ (2009)

More than a quarter of patients who attend emergency departments (A&E) in England say that they have to wait longer than the government’s four hour limit, and 14% are receiving no pain relief, according to the Healthcare Commission’s annual survey.

The survey, conducted last year in 151 trusts and involving nearly 50 000 people, shows that despite more pressure on emergency services most patients (88%) are satisfied with their care.

But it also shows that more people are waiting longer to be seen. Fewer patients were seen by a doctor or nurse within 15 minutes (40%) or examined within an hour (73%) than in the commission’s surveys …
Clinical Trials and Meta-Analysis
Authors: Jerome P. Kassirer
Journal: New England Journal of Medicine (1992)

The factors that influence doctors' decisions to embrace a new treatment are incompletely understood. Choices are influenced by advertising, medical opinion leaders, peers, and patients, but of all the sources, the most objective are randomized clinical trials. In this issue of the Journal, Lamas and colleagues show that the publication of clinical trials can have a prompt and direct effect on physicians' prescribing practices.1 The select group of physicians whose patients were enrolled in the Survival and Ventricular Enlargement trial of angiotensin-converting—enzyme inhibitors in patients who recovered from a myocardial infarction responded fairly rapidly to the published results of other . . .
DAMAGE TO THE SCIATIC NERVE FROM INTRAMUSCULAR ADMINISTRATION OF QUININE
Authors: A. G. Biggam
Journal: BMJ (1930)

InIsane 2 months 0.07 0.04 0.07 0 0S Became clear in a few days, but remained apathetic.2 Confuisional excitement, dementia 25 ?5 years 0.08 0.05 0.03 0.07 Became quiiet after years of ec- praecox citemiient.Chronlc acne cured. 3Confusional insanity, puerperal 25 Insaile 1 3ear 0.C9 0 01 0.07 Recovered. 4Confusional insanity, exhaustion 32 Insane 3 rnonths 0.07 0.07 0.03 0.07 0.06 0.06 Recovered. 5Confusional insanity, puerperal 30 ? 4 months 0.07 0.12 0.09 0.07 0.03 Recovered.6 Confusional insanity, lactational 27 Insane 5 months 0.07 0.09 0.07 0.06 0.06 0.06 Recovered.7 Confusional insanity, exhaustion 17 Alcoholic 7 months 0.18 0 18 0.34 0.14 0.1 Recovered.8 Confusional insanity, puerperal 21 Insane 4 months 0.22 0.12 0.14 0.12 0.12 0.09 Recovered.9 Confusional insanity, exhaustion 21 Alcoholic 6 months 0.08 0 03 0.03 0.03 -Recovered. 10Confulsional excitement, post-21 ?Insane 3 months 0.08 0 03 Recovered.influenzal 11 Confntsional excitement, erhaus-19 Negative 3 nmonths 0.09 0.09 0.07 Recovered.tion 12 Mental defective, congenital 24 Alcoholic 21 years 0 05 0.1 0.05 0.07 No change.syphilitic 13 G. 1'.I., excitement, confusion .. 49 Insane and 2 years 0.07 0 07 0.05 0.06 Became quieter.alcoholic 14 Organic brain disease ... ... 52 Unknown ?years 0.08 0.08 0.06 0.07 0.35 0.03 No change.15
On the Mechanism of Thrombocytopenic Purpura in Sexually Active Homosexual Men
Authors: Christina M. Walsh, Michael A. Nardi, Simon Karpatkin
Journal: New England Journal of Medicine (1984)

Thrombocytopenic purpura has recently been noted in sexually active homosexual men. To elucidate the pathogenesis of thrombocytopenic purpura in this population, we compared the disorder in 33 homosexual men with that in 23 patients (15 women and 8 men) thought to have classic autoimmune thrombocytopenic purpura. The homosexual group had 3.8-fold higher levels of platelet-bound IgG and 4.2-fold higher levels of platelet-bound complement than the patients with autoimmune thrombocytopenic purpura. Eluates from the platelets of only 1 of 10 homosexual patients reacted in vitro with normal platelets, as compared with those from the platelets of 12 of 15 patients with autoimmune thrombocytopenic purpura. Twenty-one of 24 homosexual patients (88 per cent) had elevated serum levels of immune complexes that were capable of binding to platelets, whereas none of 5 patients with autoimmune thrombocytopenic purpura had circulating immune complexes. The IgG fraction of positive serum samples from three homosexual patients did not bind to normal platelets, whereas that from the positive serum of two patients with autoimmune thrombocytopenic purpura and one woman in whom isoimmune antiplatelet antibody developed during pregnancy (studied as a positive control) did bind to normal platelets. We conclude that, whereas classic autoimmune thrombocytopenic purpura involves antiplatelet IgG directed against platelet antigenic determinants, the thrombocytopenic purpura that occurs in sexually active homosexual men is usually caused not by antiplatelet IgG but probably by the nonspecific deposition of complement and immune complexes on platelets. (N Engl J Med 1984; 311: 635–9.)
Stents or surgery?
Authors: Douglas Kamerow
Journal: BMJ (2007)

Stents are in the news. Which kind should you recommend: drug eluting stents, which may prevent early restenosis better but are more expensive and may lead to late thrombosis? Or bare metal stents, which may not be as good at preventing restenosis initially but are cheaper and less likely to lead to late thrombosis? News reports say that this controversy has now led to fewer doctors recommending drug eluting stents and some insurance companies reconsidering their coverage of them.

The larger question, of course, is not just which type of stent to use. …
Increased concentrations of immunoreactive leukotrienes in cutaneous lesions of eosinophilic cellulitis
Authors: ELIZABETH WONG, M.W. GREAVES, T. O'BRIEN
Journal: British Journal of Dermatology (1984)

A case of eosinophilic cellulitis is described. Tests of eosinophil function were normal. Radioimmunoassay identification of inflammatory mediators showed greatly increased concentrations of leukotrienes LTC4/D4 (components of slow‐reacting substance of anaphylaxis) in the affected skin. These mediators may play a causal role in the inflammation seen with eosinophilic cellulitis.
NSAIDs need not usually be withheld after orthopaedic surgery
Authors: P. G Stone, E. Richards
Journal: BMJ (1998)

EDITOR —We cannot let Varghese et al's letter go unchallenged. After extrapolation of rodent data they say that non-steroidal anti-inflammatory drugs should not be used after orthopaedic surgery.1 Prompted by similar views from some of our surgical colleagues, we recently undertook a comprehensive electronic literature search of the effects of non-steroidal anti-inflammatory drugs in orthopaedics, trauma, and bone metabolism. We also …
Homosexual related legislation does not reduce suicidal intent in sexual minority groups
Authors: R. M Mathy
Journal: BMJ (2002)

EDITOR—Bagley and D'Augelli contend that suicidal behaviour in bisexual, gay, and lesbian youth is an international problem associated with homophobic legislation.1 Heretofore, no data existed to examine this. I recently found considerable variation in suicidal behaviour by sexual orientation cross culturally.2 I re-examined the data to determine whether variations in suicidal behaviour are associated with national legislation on homosexual ( a ) adoption, ( b ) military service, ( c ) employment, and ( d ) marriage or domestic partnership.

A more detailed description of participants and methods can be found elsewhere. 3 4 Four English speaking countries were selected from the intercontinental study2 …
Proliferation of synovial lining cells and fibroblasts.
Authors: W Mohr, G Beneke, W Mohing
Journal: Annals of the Rheumatic Diseases (1975)

After in vitro incubation with 3H-thymidine, the proliferation of synovial lining cells and fibroblasts was investigated in surgically-removed articular tissue. Under normal conditions, in nonrheumatoid arthritis and in osteoarthrosis, low proliferation rates for both cell types were observed. In rheumatoid arthritis, the rate of proliferation of both cell types was usually increased. An increased proliferation of the synovial lining cells was especially observed in cases with a hyperplastic lining cell layer and in cases with a minimal lymphocytic and plasma cellular infiltration in the synovial membrane.
Intestinal Absorption of D-Xylose in Man
Authors: John S. Fordtran, Konrad H. Soergel, Franz J. Ingelfinger
Journal: New England Journal of Medicine (1962)

The d-xylose absorption test is useful in the diagnosis of tropical and idiopathic sprue,1 2 3 4 but results are variable in other disorders and in elderly persons without intestinal disease.5 , 6 Interpretation of this test is hampered by lack of information on the extent to which spontaneous variation and physiologic phenomena may affect xylose absorption. Consequently, we have studied the following aspects of dxylose absorption in the normal human intestine: the amount of an orally ingested dose that is actually absorbed in the small intestine and the degree of correlation of intestinal absorption with urinary excretion of this pentose; the site of absorption . . .
Association of Mental Health Disorders With Prescription Opioids and High-Risk Opioid Use in US Veterans of Iraq and Afghanistan
Authors: Karen H. Seal, Ying Shi, Gregory Cohen, Beth E. Cohen, Shira Maguen, Erin E. Krebs, Thomas C. Neylan
Journal: JAMA (2012)

Record numbers of Iraq and Afghanistan veterans survive their war injuries and yet continue to experience pain and mental health problems, particularly posttraumatic stress disorder (PTSD). Little is known about the association of mental health disorders and prescription opioid use.To investigate the effect of mental health disorders, particularly PTSD, on risks and adverse clinical outcomes associated with prescription opioid use.Retrospective cohort study involving 141,029 Iraq and Afghanistan veterans who received at least 1 non-cancer-related pain diagnosis within 1 year of entering the Department of Veterans Affairs (VA) health care system from October 1, 2005, through December 31, 2010.Independent association of mental health disorders and the prescription of opioids, higher risk opioid use, and adverse clinical outcomes (eg, accidents and overdose) within 1 year of receiving a pain-related diagnosis.A total of 15,676 veterans were prescribed opioids within 1 year of their initial pain diagnosis. Compared with 6.5% of veterans without mental health disorders, 17.8% (adjusted relative risk [RR], 2.58; 95% CI, 2.49-2.67) of veterans with PTSD and 11.7% (adjusted RR, 1.74; 95% CI, 1.67-1.82) with other mental health diagnoses but without PTSD were significantly more likely to receive opioids for pain diagnoses. Of those who were prescribed pain medication, veterans with PTSD were more likely than those without mental health disorders to receive higher-dose opioids (22.7% vs 15.9%, adjusted RR, 1.42; 95% CI, 1.31-1.54), receive 2 or more opioids concurrently (19.8% vs 10.7%, adjusted RR, 1.87; 95% CI, 1.70-2.06), receive sedative hypnotics concurrently (40.7% vs 7.6%, adjusted RR, 5.46; 95% CI, 4.91-6.07), or obtain early opioid refills (33.8% vs 20.4%; adjusted RR, 1.64; 95% CI, 1.53-1.75). Receiving prescription opioids (vs not) was associated with an increased risk of adverse clinical outcomes for all veterans (9.5% vs 4.1%; RR, 2.33; 95% CI, 2.20-2.46), which was most pronounced in veterans with PTSD.Among US veterans of Iraq and Afghanistan, mental health diagnoses, especially PTSD, were associated with an increased risk of receiving opioids for pain, high-risk opioid use, and adverse clinical outcomes.
Isolated Ventricular Septal Defect of the Persistent Common Atrioventricular Canal Type
Authors: HENRY N. NEUFELD, JACK L. TITUS, JAMES W. DUSHANE, HOWARD B. BURCHELL, JESSE E. EDWARDS
Journal: Circulation (1961)

Among 60 necropsy specimens of isolated ventricular septal defects and more than 300 cases of ventricular septal defect observed at operation, 15 cases demonstrating unusual anatomic positions of the defect were found. The ventricular defect differed from the ordinary ventricular septal defect in that it usually occupied the position of the ventricular component of the defect in persistent common atrioventricular canal. For this reason it was named ventricular septal defect of the persistent common atrioventricular canal type. Deformities of one or both atrioventricular valves were common (nine of 15 cases). No atrial septal defects of the ostium primum type were present. Anatomic studies of the conduction tissue revealed that this tissue skirted the posterior and inferior aspects of the ventricular septal defect and that, as in persistent common atrioventricular canal, the course taken by the conduction tissue was unusually long, as a result of the peculiar posteroinferior position of the lower edge of the defect. The electrocardiographic features were striking. In all cases the mean electrical axis of the QRS lay above the isoelectric point; the vector loop obtained in the frontal plane from the scalar electrocardiogram was directed counterclockwise, and its main mass was above the zero line. In addition, in all cases there were signs of right ventricular overload, and in some cases of left ventricular overload as well. Electrocardiographic findings of this pattern have been thought by some authors to be diagnostic of persistent common atrioventricular canal, but we observed that they also occurred in each of the cases of isolated ventricular septal defect of the variety described herein. We recognize that in the usual variety of ventricular septal defect this electrocardiographic pattern occurs, but it does so uncommonly. We have not studied its exact incidence. The anatomy, hemodynamics, and surgical considerations are different in cases with this defect from those with persistent common atrioventricular canal. The surgical risk in these cases has been higher than that in the usual type of ventricular septal defect. In the discussion of the electrophysiologic theories that seek to explain the unusual electrocardiographic patterns in this group of cases, a new theory is offered, based on studies of the conduction system. In our opinion, the different orientation of the advancing fronts of depolarization is the result of congenital displacement of the bundle of His in its relation to the ventricular septal defect.
THE PROTECTION OF BODY CASTS BY CELLOPHANE
Authors: Bernard N. E. Cohn
Journal: JAMA (1934)

The adequate handling of children to prevent soiling of body casts presents a difficult problem even in orthopedic institutions where the nursing personnel is especially trained to care for such patients. In general hospitals one depends on a regimen of watchful waiting to cope with such a situation, often without success. It taxes the patience of the surgeon who applies a satisfactory body cast only to find it so soiled in a few days that a new one is required. In order to obviate such altogether too frequent occurrences, a simple and inexpensive means was sought. Various methods for accomplishing this purpose are already in vogue, the most common of which is shellacking the part around the perineal region or covering it with oiled silk. Neither of these is entirely satisfactory from the standpoint of time and expense involved. It has been found that cellophane affords the easiest and most
669 Chronic liver damage after an episode of idiosyncratic drug induced liver injury (DILI)
Authors: R.J. Andrade, M.I. Lucena, K. Pachkoria, Y. Borraz, N. Kaplowitz, B. García-Muñoz, M. García-Cortés, M.C. Fernandez, G. Pelaez, L. Rodrigo, J.A. Durán, R. Planas, A. Soler, C. Guarner, M. Romero-Gómez, T. Muñoz-Yagüe
Journal: Journal of Hepatology (2006)
894 IL28B-BASED MODEL FOR PREDICTION OF WEEK 4 VIRAL RESPONSE IN PEGINTERFERON-alfa2a + RIBAVIRIN TREATED HEPATITIS C GENOTYPE 1&amp;4. FINAL REPORT WEEK 4 OPTIM STUDY
Authors: M. Romero-Gómez, B. de Cuenca, E. Baeyens, J. García- Samaniego, J. Salmeron, M.D.M. Alonso, J. Buenestado, R. Muñoz, M. Diago, A. García, C. Mínguez, L. Morano, J.A. Girón, J. González-García, J. Crespo, R. Planas, J. Turnes, J.L. Calleja, R. Solà
Journal: Journal of Hepatology (2013)