tbuckley/cabot-search huggingface dataset:
THYROTOXICOSIS IN ELDERLY PERSONS WITHOUT SIGNS OF GOITER
Authors: HUGO A. FREUND
Journal: JAMA (1930)

Killins,<sup>1</sup>in a discussion of the diagnosis of exophthalmic goiter in elderly persons, points out the difficulty of recognizing the condition in patients over 55 years of age. He stresses the fact that there is "rarely a history of thyroid enlargement preceding the onset of the illness" and, furthermore, that even after the disease has been established for many months, swelling of the neck is unusual. That hyperthyroidism may exist without evidence of goiter is generally recognized by clinicians, though perhaps not thoroughly enough emphasized. Tucker<sup>2</sup>called attention to this fact when he reported three cases of hyperthyroidism in which there was no visible or palpable thyroid enlargement and in which the correct diagnosis was not suspected by three observers. Mohler<sup>3</sup>had previously reported a like number, of which one occurred in an elderly individual. It is the latter type that concerns us particularly in this discussion,
162 Non-alcoholic fatty liver disease-A common disorder in patients presenting for laparoscopic cholecystectomy
Authors: M WELTMAN, A DAS, C MARTIN, J WYATT, M COX
Journal: Hepatology (2003)

Premature and ill term babies born in regional Australia must be moved to another hospital with Neonatal Intensive Care Unit (NICU) facilities. Transferred pre-term and critically ill term babies have higher mortality rates and much higher rates of long term disability than similar babies born in hospitals with NICU facilities. This paper details the Bush Babies Broadband project that aims to significantly improve the quality of treatment for babies born in rural, remote as well as urban areas by providing the first on-demand virtual NICU architecture in Australia. Real-time data collected from medical monitors and ventilators attached to the baby, audiovisual streams and static physiological data such as X-ray images are transmitted to the consulting Neonatologist to gain a better picture of the patient's condition than is currently available. The key contribution of this significant research is the infrastructure providing a mechanism for Neonatologists to receive information directly from a regional hospital, thereby preventing, in some cases, the immediate need to move the baby. A key benefit of this framework is that it is available to link regional hospitals with the supporting NICU Neonatologist ‘on demand’ eliminating the need to establish permanent point to point connections. This paper further describes the application of that architecture to a specific pilot connecting the Bathurst regional hospital with Neonatologists within the NICU at Nepean Hospital, Penrith Australia.
Ventricular Precontracting Area in the Wolff-Parkinson-White Syndrome
Authors: GIULIO BANDIERA, PIER FAUSTO ANTOGNETTI
Journal: Circulation (1958)

By means of the analytic method of roentgenkymography of Cignolini, 11 typical cases of Wolff-Parkinson-White syndrome were studied. Comparison of the kymographic tracings with the synchronously registered electrocardiogram demonstrated precocious contraction of a limited ventricular area, situated in the left ventricle in the A type and in the right ventricle in the B type.
Cervical carcinoma: prognosis in younger patients.
Authors: J M Russell, V Blair, R D Hunter
Journal: BMJ (1987)

Retrospective analysis of 2870 patients with invasive carcinoma of the cervix treated by radiotherapy from 1971 to 1978 showed that the prognosis for younger patients (defined as either under 35 or under 40) was better than that for older age groups, but young patients presented with earlier disease. When the effect of stage on prognosis was also considered the improved survival of patients under 35 was confirmed, although the result was of only borderline significance. The better survival of younger patients was particularly noticeable for stage IB disease, the corrected five year survival of those under 35 being 93% compared with 79% for those over 35. On the basis of this analysis and a review of previous reports it is concluded that age alone is a poor indicator of prognosis and should not be used as an indication for adjuvant treatment. There is no evidence in this series of an aggressive form of cervical carcinoma in younger patients during the 1970s.
Efficient suppression of murine intracellular adhesion molecule-1 using ultrasound-responsive and mannose-modified lipoplexes inhibits acute hepatic inflammation
Authors: Keita Un, Shigeru Kawakami, Mitsuru Yoshida, Yuriko Higuchi, Ryo Suzuki, Kazuo Maruyama, Fumiyoshi Yamashita, Mitsuru Hashida
Journal: Hepatology (2012)

Hepatitis is often associated with the overexpression of various adhesion molecules. In particular, intracellular adhesion molecule-1 (ICAM-1), which is expressed on hepatic endothelial cells (HECs) in the early stage of inflammation, is involved in serious illnesses. Therefore, ICAM-1 suppression in HECs enables the suppression of inflammatory responses. Here, we developed an ICAM-1 small interfering RNA (siRNA) transfer method using ultrasound (US)-responsive and mannose-modified liposome/ICAM-1 siRNA complexes (Man-PEG(2000) bubble lipoplexes [Man-PEG(2000) BLs]), and achieved efficient HEC-selective ICAM-1 siRNA delivery in combination with US exposure. Moreover, the sufficient ICAM-1 suppression effects were obtained via this ICAM-1 siRNA transfer in vitro and in vivo, and potent anti-inflammatory effects were observed in various types of inflammation, such as lipopolysaccharide, dimethylnitrosamine, carbon tetrachloride, and ischemia/reperfusion-induced inflammatory mouse models.HEC-selective and efficient ICAM-1 siRNA delivery using Man-PEG(2000) BLs and US exposure enables suppression of various types of acute hepatic inflammation. This novel siRNA delivery method may offer a valuable system for medical treatment where the targeted cells are HECs.
Taste loss persists after head/neck irradiation
Authors: Milan Korcok
Journal: JAMA (1982)

Taste loss and salivary dysfunction are usually considered unavoidable complications of radiotherapy for head and neck cancers. Now a new study, reported by a team of scientists from the Georgetown University Medical Center, Washington, DC, shows that impaired taste and salivary function may persist in some patients much longer than has been generally thought (in this series, up to seven years after radiotherapy). Kenneth L. Mossman, MD, associate professor in Georgetown's Department of Radiation Medicine, told the annual meeting of the American Society of Therapeutic Radiologists in Miami Beach that 13 patients who had been irradiated for tumors of the head and neck from one to seven years previously were followed up. Twelve had been given a total dose of 6,000 to 7,000 rad over six to eight weeks. One patient with lymphoma had been given 3,000 rad in four weeks. All but one patient received radiation in the full
A New, Easily Inserted Catheter for Intermittent Peritoneal Dialysis
Authors: Sherman Kupfer
Journal: JAMA (1967)

A new flexible catheter for peritoneal dialysis has been used over a 15-month period in 15 patients for a total of 100 days of dialysis. The catheter is easy to insert, and its insertion causes little or no trauma. For the most part, the catheter has been reintroduced without serious clinical or technical difficulties for each intermittent course of treatment in patients with either acute or chronic uremia. The risk of intra-abdominal infection is thereby reduced. Details of the procedure for peritoneal dialysis and the composition of the fluids generally used for managing various clinical states associated with uremia are outlined.
Using internet to access confidential patient records
Authors: S N Walker
Journal: BMJ (2001)

EDITOR—I am extremely concerned that an article as out of date as Chadwick et al's was published by the BMJ .1 The editorial panel of the BMJ is clearly unaware of important and well publicised developments in information technology that have taken place over the past year and a quarter.

The information in Chadwick et al's article about NHSnet is incorrect in almost all respects. General practitioners do not have to pay either to connect to or use NHSnet, and uptake is increasing rapidly. By 1 October 2000, 70% of practices in England had an ISDN line (a telephone line giving high speed internet access) installed that connected them to the network; many …
Human Autoimmunity, with Pernicious Anemia as a Model
Authors: LEONARD S. GOLDBERG
Journal: Annals of Internal Medicine (1974)

Many investigators consider pernicious anemia an autoimmune disease. Cellular and humoral immunity to gastric antigens, particularly intrinsic factor, has been found in most patients with this disorder. Although a cause-effect relation between these immune abnormalities and the disease process is unproved, current evidence suggests that cell-mediated immune mechanisms may be responsible for the atrophic gastritis in pernicious anemia. Like several other presumed autoimmune disorders, this disease occurs with increased frequency in immunodeficiency states; this association raises the possibility that autoimmunity may be the consequence of a deficient rather than a heightened immune response. Thus, pernicious anemia appears to represent an excellent model to study the interrelations between autoimmune disease, cellular and humoral immune mechanisms, and immunodeficiency states.
Integrated genomic and epigenomic analyses pinpoint biallelic gene inactivation in tumors
Authors: Giuseppe Zardo, Maarit I. Tiirikainen, Chibo Hong, Anjan Misra, Burt G. Feuerstein, Stanislav Volik, Colin C. Collins, Kathleen R. Lamborn, Andrew Bollen, Daniel Pinkel, Donna G. Albertson, Joseph F. Costello
Journal: Nature Genetics (2002)
Blood lipid concentrations and other cardiovascular risk factors: distribution, prevalence, and detection in Britain
Authors: J I Mann, B Lewis, J Shepherd, A F Winder, S Fenster, L Rose, B Morgan
Journal: BMJ (1988)

To establish the distribution of blood lipid concentrations and the prevalences of other risk factors for cardiovascular disease in Britain 12 092 men and women aged 25-59 in Glasgow, Leicester, London, and Oxford were studied. Subjects were selected by opportunistic case finding, in which patients consulting their general practitioner for any reason were offered a health check by appointment, or random selection from age-sex registers, in which an invitation for a health check was posted. The overall rate of response was 73%, being 91-94% by opportunistic case finding and 36-63% by random selection. At the health check subjects answered a brief questionnaire about risk factors for cardiovascular disease, and their height, weight, and blood pressure were recorded; a blood sample was taken for measuring plasma concentrations of cholesterol, triglyceride, high density lipoprotein cholesterol, and glucose. The mean cholesterol concentrations were 5·9 (SD 1·2) and 5·8 (1·2) mmol/l in men and women, respectively. In London the mean value was 5·5 (1·2) mmol/l for both men and women and was significantly lower than mean values in the three other centres, among which there were no significant differences. In men and women aged 25-29 concentrations were similar but they increased in men until the age of 45-49, after which they showed no further increase; in women concentrations did not increase until the age of 40-44 and by the age of 50-59 values were higher than in men. Mean triglyceride concentrations were significantly higher in men than in women (1·8 (1·4) v 1·3 (0·9) mmol/l, respectively), and trends with age were similar to those for cholesterol concentrations, except that at no age were values higher in women than in men. Mean triglyceride values overall were higher in Glasgow and London than in Oxford and Leicester. Body mass index was higher in Glasgow and London than in the other two centres and correlated with systolic and diastolic blood pressures and triglyceride concentration. In addition, subjects in Glasgow smoked significantly more than those in the other centres. These observations could contribute to the higher rate of coronary heart disease in Glasgow. Plasma lipid concentrations and the prevalences of other risk factors for cardiovascular disease were similar in subjects selected by opportunistic case finding and by random selection. In Britain cholesterol values have changed little during the past 12 years despite dietary recommendations and health education. Identifying subjects at particularly high risk of coronary heart disease is required to supplement advice to the general population to reduce the prevalence of this disease. Opportunistic case finding would be an appropriate method of identifying such subjects in general practice, although none of the potential markers for hyperlipidaemia was particularly useful in identifying all subjects at high risk.
Which parameters might predict complications after natural orifice endoluminal surgery (NOTES)? Results from a randomized comparison with open surgical access in pigs
Authors: A. Fritscher-Ravens, A. Ghanbari, S. Thompson, K. Patel, E. Kahle, T. Fritscher, H. Niemann, P. Koehler, P. Milla
Journal: Endoscopy (2007)

See also: Commentaire des travaux de A. Fritscher-Ravens et al. pp. 870 et pp. 888Endoscopy 2007; 39(10): 933-934DOI: 10.1055/s-0032-1308875
Abstract P5-04-11: CDK11p58 inhibits estrogen receptor a positive breast cancer invasion via integrinb3 through repressing ERa signaling
Authors: Y Chi, L Wang, L Wang, P Wei, J Wu
Journal: Cancer Research (2013)

Abstract Background: The sex steroid estrogen plays a major role in the development and progression of breast cancer. Estrogen promotes breast cancer proliferation through a number of established pathways. CDK11p58, a Ser/Thr kinase which belongs to Cell Division Cycle 2-like 1 (CDC2L1) subfamily, is associated with cell cycle progression, tumorigenesis and apoptotic signaling. In the previous study, we found that CDK11p58 interacted with estrogen receptor a (ERa) in breast tumor cells and repressed ERa transcriptional activity through promoting its ubiquitin/proteasome-mediated degradation. Here we sought to investigate the critical role of CDK11p58 in the carcinogenisis of breast cancer. Methods and results: We measured the expression of CDK11p58 in 132 pairs of breast cancer tissues and adjacent tissues by IHC and qPCR. The mRNA and protein level of CDK11p58 were significant higher in breast cancer tissues than those in normal breast tissues. Interestingly, low expression of CDK11 was associated with lymph nodes metastasis in patients (P&amp;lt;0.05). Using the ERa + cell lines ZR-75-30 and T47D, we found CDK11p58 could repress the migration and invasion of ERa positive breast cancer cells. We further demonstrated that mRNA of integrinb3 were dramatically repressed by CDK11p58 by the TaqMan® Metastasis Gene Expression Assays. The effect was CDK11p58 kinase activity dependent. Expression of integrinβ3 was highly related with ERa signaling. While overexpression ERa stimulates integrinβ3 expression, knockdown of ERa attenuates integrinβ3 expression. By the Dual-luciferase array and CHIP assay, we found estrogen response elements (ERE) indeed existed in integrinβ3 promoter. ERa bound to the ERE on the integrinβ3 promoter and increased its transcription. Conclusions: Our findings provide mechanistic insights into how CDK11p58 regulated the expression of integrinβ3 to inhibit the cell invasion though repressing the signaling of ERa in a kinase activity dependent way. These data indicate that CDK11p58 is an antimetastasis gene product in breast cancer and regulation of integrinβ3 by CDK11p58 through ERa could be part of a signaling pathway that determines and explains breast cancer invasion and metastasis. Citation Information: Cancer Res 2013;73(24 Suppl): Abstract nr P5-04-11.
Effects of a School-based Intervention for Urban Adolescents with Asthma
Authors: Jean-Marie Bruzzese, Beverley J. Sheares, Elisa J. Vincent, Yunling Du, Hossein Sadeghi, Moshe J. Levison, Robert B. Mellins, David Evans
Journal: American Journal of Respiratory and Critical Care Medicine (2010)

Asthma prevalence and morbidity are especially elevated in adolescents, yet few interventions target this population.To test the efficacy of Asthma Self-Management for Adolescents (ASMA), a school-based intervention for adolescents and medical providers.Three hundred forty-five primarily Latino/a (46%) and African American (31%) high school students (mean age = 15.1 yr; 70% female) reporting an asthma diagnosis, symptoms of moderate to severe persistent asthma, and asthma medication use in the last 12 months were randomized to ASMA, an 8-week school-based intervention, or a wait-list control group. They were followed for 12 months.Students completed bimonthly assessments. Baseline, 6-month, and 12-month assessments were comprehensive; the others assessed interim health outcomes and urgent health care use. Primary outcomes were asthma self-management, symptom frequency, and quality of life (QOL); secondary outcomes were asthma medical management, school absences, days with activity limitations, and urgent health care use. Relative to control subjects, ASMA students reported significantly: more confidence to manage their asthma; taking more steps to prevent symptoms; greater use of controller medication and written treatment plans; fewer night awakenings, days with activity limitation, and school absences due to asthma; improved QOL; and fewer acute care visits, emergency department visits, and hospitalizations. In contrast, steps to manage asthma episodes, daytime symptom frequency, and school-reported absences did not differentiate the two groups. Most results were sustained over the 12 months.ASMA is efficacious in improving asthma self-management and reducing asthma morbidity and urgent health care use in low-income urban minority adolescents.
Underlying steatohepatitis, but not simple hepatic steatosis, increases morbidity after liver resection: A case-control study
Authors: Srinevas K. Reddy, J. Wallis Marsh, Patrick R. Varley, Brady K. Mock, Kapil B. Chopra, David A. Geller, Allan Tsung
Journal: Hepatology (2012)

Despite the high prevalence of fatty liver disease, the safety of liver resection in settings of steatohepatitis (SH) or hepatic steatosis is poorly understood. The aim of this study was to determine whether underlying SH or simple hepatic steatosis increases morbidity after liver resection. We compared patients undergoing liver resection with underlying SH or greater than 33% simple hepatic steatosis to controls selected for similar demographics, diagnoses, comorbidities, preoperative chemotherapy treatments, and extent of partial hepatectomy. Primary endpoints included postoperative overall and hepatic-related morbidity. One hundred and two patients with SH and 72 with greater than 33% simple hepatic steatosis who underwent liver resection from 2000 to 2011 were compared to corresponding controls. There were no differences in extent or approach of liver resection, malignant indications, preoperative chemotherapy treatment, elements of metabolic syndrome, alcohol use history, American Society of Anesthesiologists score, age, or gender between patients with SH or simple steatosis and corresponding controls. Ninety-day postoperative overall morbidity (56.9% versus 37.3%; P = 0.008), any hepatic-related morbidity (28.4% versus 15.7%; P = 0.043), surgical hepatic complications (19.6% versus 8.8%; P = 0.046), and hepatic decompensation (16.7% versus 6.9%; P = 0.049) were greater among SH patients, compared to corresponding controls. In contrast, there were no differences in postoperative overall morbidity (34.7% versus 44.4%; P = 0.310), any hepatic-related morbidity (19.4% versus 19.4%; P = 1.000), surgical hepatic complications (13.9% versus 9.7%; P = 0.606), or hepatic decompensation (8.3% versus 9.7%; P = 0.778) between simple hepatic steatosis patients and corresponding controls. Using multivariable logistic regression, SH was independently associated with postoperative overall (odds ratio [OR], 2.316; 95% confidence interval [95% CI]: 1.267-4.241; P = 0.007) and any hepatic-related (OR, 2.722; 95% CI: 1.201-6.168; P = 0.016) morbidity.Underlying SH, but not simple hepatic steatosis, increases overall and hepatic-related morbidity after liver resection.
Outcomes With Concurrent Use of Clopidogrel and Proton-Pump Inhibitors
Authors: Wayne A. Ray
Journal: Annals of Internal Medicine (2010)

Proton-pump inhibitors (PPIs) and clopidogrel are frequently coprescribed, although the benefits and harms of their concurrent use are unclear.To examine the association between concurrent use of PPIs and clopidogrel and the risks for hospitalizations for gastroduodenal bleeding and serious cardiovascular disease.Retrospective cohort study using automated data to identify patients who received clopidogrel between 1999 through 2005 after hospitalization for coronary heart disease.Tennessee Medicaid program.20,596 patients (including 7593 concurrent users of clopidogrel and PPIs) hospitalized for myocardial infarction, coronary artery revascularization, or unstable angina pectoris.Baseline and follow-up drug use was assessed from automated records of dispensed prescriptions. Primary outcomes were hospitalizations for gastroduodenal bleeding and serious cardiovascular disease (fatal or nonfatal myocardial infarction or sudden cardiac death, stroke, or other cardiovascular death).Pantoprazole and omeprazole accounted for 62% and 9% of concurrent PPI use, respectively. Adjusted incidence of hospitalization for gastroduodenal bleeding in concurrent PPI users was 50% lower than that in nonusers (hazard ratio, 0.50 [95% CI, 0.39 to 0.65]). For patients at highest risk for bleeding, PPI use was associated with an absolute reduction of 28.5 (CI, 11.7 to 36.9) hospitalizations for gastroduodenal bleeding per 1000 person-years. The hazard ratio associated with concurrent PPI use for risk for serious cardiovascular disease was 0.99 (CI, 0.82 to 1.19) for the entire cohort and 1.01 (CI, 0.76 to 1.34) for the subgroup of patients who had percutaneous coronary interventions with stenting during the qualifying hospitalization.Unmeasured confounding and misclassification of exposure (no information on adherence or over-the-counter use of drugs) and end points (not confirmed by medical record review) were possible. Because many patients entered the cohort from hospitals with relatively few cohort members, the analysis relied on the assumption that after adjustment for observed covariates, PPI users from one such hospital could be compared with nonusers from a different hospital.In patients with serious coronary heart disease treated with clopidogrel, concurrent PPI use was associated with reduced incidence of hospitalizations for gastroduodenal bleeding. The corresponding point estimate for serious cardiovascular disease was not increased; however, the 95% CI included a clinically important increased risk.Agency for Healthcare Research and Quality and National Heart, Lung, and Blood Institute.