CHOLINE AS AN ADJUVANT TO THE DIETARY THERAPY OF CIRRHOSIS OF THE LIVER
Authors: A. H. Russakoff, Harold Blumberg
Journal: Annals of Internal Medicine (1944)

Article1 November 1944CHOLINE AS AN ADJUVANT TO THE DIETARY THERAPY OF CIRRHOSIS OF THE LIVERA. H. RUSSAKOFF, M.D., HAROLD BLUMBERG, SC.D.A. H. RUSSAKOFF, M.D.Search for more papers by this author, HAROLD BLUMBERG, SC.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-21-5-848 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe past several years have seen a change in the treatment of portal cirrhosis of the liver, particularly in regard to the rôle of diet in therapy. This is especially true of alcoholic cirrhosis, the type which constitutes a majority of the cases of cirrhosis observed in the United States (Ratnoff and Patek1). The change has been brought about by experimental and clinical observations.Connor2, 3emphasized the importance of prolonged fatty infiltration of the liver in the development of cirrhosis in diabetes and in chronic alcoholism. Experimental support for this theory was found in 1938 when Chaikoff, Connor, and...Bibliography1. RATNOFFPATEK ODAJ: The natural history of Laennec's cirrhosis of the liver, Medicine, 1942, xxi, 207-268. CrossrefGoogle Scholar2. CONNOR CL: Fatty infiltration of the liver and the development of cirrhosis in diabetes and chronic alcoholism, Am. Jr. Path., 1938, xiv, 347-364. Google Scholar3. CONNOR CL: The etiology and pathogenesis of alcoholic cirrhosis of the liver, Jr. Am. Med. Assoc., 1939, cxii, 387-390. CrossrefGoogle Scholar4. CHAIKOFFCONNORBISKIND ILCLGR: Fatty infiltration and cirrhosis of the liver in depancreatized dogs maintained with insulin, Am. Jr. Path., 1938, xiv, 101-110. Google Scholar5. CONNORCHAIKOFF CLIL: Production of cirrhosis in fatty livers with alcohol, Proc. Soc. Exper. Biol. and Med., 1938, xxxix, 356-359. CrossrefGoogle Scholar6. BLUMBERG H: Attempts to produce tumors in rats by feeding crude wheat germ oil made by prolonged ether extraction, Pub. Health Rep., 1940, lv, 531-537. CrossrefGoogle Scholar7. BLUMBERGGRADY HHG: The production of diffuse nodular cirrhosis of the liver in rats on high fat-low protein diets, Jr. Biol. Chem., 1941, cxl, 15. Google Scholar8. BLUMBERGGRADY HHG: Production of cirrhosis of the liver in rats by feeding low protein, high fat diets, Arch. Path., 1942, xxxiv, 1035-1041. Google Scholar9. CHAIKOFFCONNOR ILCL: Production of cirrhosis of the liver of the normal dog by high fat diets, Proc. Soc. Exper. Biol. and Med., 1940, xliii, 638-641. CrossrefGoogle Scholar10. CHAIKOFFEICHORNCONNORENTENMAN ILKBCLC: The production of cirrhosis in the liver of the normal dog by prolonged feeding of a high-fat diet, Am. Jr. Path., 1943, xix, 9-21. Google Scholar11. GYÖRGYGOLDBLATT PH: Hepatic injury on a nutritional basis in rats, Jr. Exper. Med., 1939, lxx, 185-192. CrossrefGoogle Scholar12. RICHHAMILTON ARJD: The experimental production of cirrhosis of the liver by means of a deficient diet, Bull. Johns Hopkins Hosp., 1940, lxvi, 185-198. Google Scholar13. RICHHAMILTON ARJD: Further studies on cirrhosis of the liver produced by a dietary deficiency, Trans. Assoc. Am. Phys., 1940, lv, 133-139. Google Scholar14. GYÖRGYGOLDBLATT PH: Experimental production of dietary liver injury (necrosis, cirrhosis) in rats, Proc. Soc. Exper. Biol. and Med., 1941, xlvi, 492-494. CrossrefGoogle Scholar15. GYÖRGYGOLDBLATT PH: Observations on the conditions of dietary hepatic injury (necrosis, cirrhosis) in rats, Jr. Exper. Med., 1942, lxxv, 355-368. CrossrefGoogle Scholar16. BLUMBERGGRADY HHG: Read before American Society for Experimental Pathology, Chicago, April 19, 1941. Google Scholar17. BLUMBERGMCCOLLUM HEV: The prevention by choline of liver cirrhosis in rats on high fat, low protein diets, Science, 1941, xciii, 598-599. CrossrefGoogle Scholar18. LILLIEDAFTSEBRELL RDFSWH: Cirrhosis of the liver in rats on a deficient diet and the effect of alcohol, Pub. Health Rep., 1941, lvi, 1255-1258. CrossrefGoogle Scholar19. DAFTSEBRELLLILLIE FSWHRD: Production and apparent prevention of a dietary liver cirrhosis in rats, Proc. Soc. Exper. Biol. and Med., 1941, xlviii, 228-229. CrossrefGoogle Scholar20. WEBSTER GT: Cirrhosis of the liver among rats receiving diets poor in protein and rich in fat, Jr. Clin. Invest., 1942, xxi, 385-392. CrossrefGoogle Scholar21. SPELLBERGKEETON MARW: The production of fatty and fibrotic livers in guinea pigs and rabbits by seemingly adequate diets, Am. Jr. Med. Sci., 1940, cc, 688-697. CrossrefGoogle Scholar22. SPELLBERGKEETONGINSBERG MARWR: Dietary production of hepatic cirrhosis in rabbits, Arch. Path., 1942, xxxiii, 204-217. Google Scholar23. BLUMBERGMACKENZIESELIGSON HCGD: The prevention by choline, methionine, or casein of dietary cirrhosis of the liver in rats and rabbits, Federation Proc., 1942, i, 187. Google Scholar24. FOUTS PJ: Vitamin B complex studies in dogs: production of cirrhosis of liver, Jr. Nutr., 1943, xxv, 217-228. CrossrefGoogle Scholar25. BESTHERSHEYHUNTSMAN CHJMME: The control of the deposition of liver fat, Am. Jr. Physiol., 1932, ci, 7. Google Scholar26. BESTHUNTSMAN CHME: The effects of the components of lecithine upon deposition of fat in the liver, Jr. Physiol., 1932, lxxv, 405-412. CrossrefGoogle Scholar27. EARLEVICTOR DPJ: Cirrhosis of the liver caused by excess dietary cystine, Jr. Exper. Med., 1941, lxxiii, 161-172. CrossrefGoogle Scholar28. LOWRYDAFTSEBRELLASHBURNLILLIE JVFSWHLLRD: Treatment of dietary liver cirrhosis in rats with choline and casein, Pub. Health Rep., 1941, lvi, 2216-2219. CrossrefGoogle Scholar29. BLUMBERG H: Unpublished data. Google Scholar30. PATEK AJ: Treatment of alcoholic cirrhosis of the liver with high vitamin therapy, Proc. Soc. Exper. Biol. and Med., 1937, xxxvii, 329-330. CrossrefGoogle Scholar31. PATEKPOST AJJ: Treatment of cirrhosis of the liver by a nutritious diet and supplements rich in vitamin B complex, Jr. Clin. Invest., 1941, xx, 481-505. CrossrefGoogle Scholar32. PATEK AJ: Dietary treatment of Laennec's cirrhosis with special reference to early stages of the disease, Bull. New York Acad. Med. (second Series), 1943, xix, 498-506. Google Scholar33. FLEMINGSNELL RGAM: Portal cirrhosis with ascites: An analysis of 200 cases with special reference to prognosis and treatment, Am. Jr. Digest. Dis., 1942, ix, 115-120. CrossrefGoogle Scholar34. SNELL AM: Recent advances in the treatment of hepatic disease, Minnesota Med., 1940, xxiii, 551-556. Google Scholar35. BUTTSNELL HRAM: Recent trends in treatment of cirrhosis of the liver, Proc. Staff Meet. Mayo Clin., 1942, xxvii, 250-254. Google Scholar36. GOODHARTJOLLIFFE RN: Effects of vitamin B (B1) therapy on the polyneuritis of alcohol addicts, Jr. Am. Med. Assoc., 1938, cx, 414-418. CrossrefGoogle Scholar37. WAYBURNGUERARD ECR: Relation between multiple peripheral neuropathy and cirrhosis of the liver, Arch. Int. Med., 1940, lxvi, 161-172. CrossrefGoogle Scholar38. KEEFERFRIES CSED: The fatty liver—its diagnosis and clinical course, Trans. Assoc. Am. Phys., 1942, lvii, 283-288. Google Scholar39. RALLIPALEYRUBIN EPKSH: The liver lipids and their distribution in disease. An analysis of 60 human livers, Jr. Clin. Invest., 1941, xx, 413-417. CrossrefGoogle Scholar40. THANNHAUSERREINSTEIN SJH: Fatty changes in the liver from different causes: comparative studies of the lipid partition, Arch. Path., 1942, xxxiii, 646-654. Google Scholar41. BROUNMUETHER GORO: Treatment of hepatic cirrhosis with choline chloride and diet low in fat and cholesterol. Proc. Central Soc. Clin. Res., in Jr. Am. Med. Assoc., 1942, cxviii, 1403. Google Scholar42. RAVDINTHOROGOODRIEGELPETERSRHOADS ISECRJE: The prevention of liver damage and the facilitation of repair in the liver by diet, Jr. Am. Med. Assoc., 1943, cxxi, 322-325. CrossrefGoogle Scholar43. FAGINZINN IDFT: Cirrhosis of the liver: results of treatment with parenterally administered amino acids, Jr. Lab. and Clin. Med., 1942, xxvii, 1400-1409. Google Scholar44. FAGINSAHYUNPAGEL IDMRW: Cirrhosis of the liver: the lipotropic action of parenterally administered amino acids, Jr. Lab. and Clin. Med., 1943, xxviii, 987-993. Google Scholar45. HOAGLAND CL: In Conferences on Therapy: The modern treatment of cirrhosis of the liver and hepatic insufficiency, New York State Jr. Med., 1943, xliii, 1041-1048. Google Scholar46. LECOUNTSINGER ERHA: Fat replacement of the glycogen in the liver as a cause of death, Arch. Path. Lab. Med., 1926, i, 84-89. Google Scholar47. GRAHAM RL: Sudden death in young adults in association with fatty liver, Bull. Johns Hopkins Hosp., 1944, lxxiv, 16-25. Google Scholar48. DANISANDERSON PGWA: Choline chloride in the treatment of icterus gravis neonatorum, South. Med. Jr., 1942, xxxv, 1070-1076. CrossrefGoogle Scholar49. GAVINMCHENRY GEW: Inositol: a lipotropic factor, Jr. Biol. Chem., 1941, cxxxix, 485. CrossrefGoogle Scholar50. GAVINPATTERSONMCHENRY GJMEW: Comparison of the lipotropic effects of choline, inositol, and lipocaic in rats, Jr. Biol. Chem., 1943, cxlviii, 275-279. CrossrefGoogle Scholar51. YATER WM: In discussion of paper by C. H. GREENE, Jr. Am. Med. Assoc., 1943, cxxi, 720. Google Scholar52. GORDON ES: Personal communication. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Baltimore, Maryland*Received for publication May 23, 1944.From the Medical Service, Sinai Hospital (A.H.R.), and the Department of Biochemistry, School of Hygiene and Public Health, Johns Hopkins University (H.B.)†Formerly Resident in Medicine, Sinai Hospital, Baltimore, Maryland; now Assistant Surgeon (R), U. S. Public Health Service. 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The CirrhosesProtein NutritionAn Assay for Choline Chloride in Pharmaceutical Products*Effect of Methionine Supplements on Hepatic Injury Produced by Carbon Tetrachloride 1 November 1944Volume 21, Issue 5Page: 848-862KeywordsChloridesCirrhosisHospital medicineHygieneLiverMedical servicesPrevention, policy, and public healthResearch fundingSurgeonsTechnicians ePublished: 1 December 2008 Issue Published: 1 November 1944 PDF downloadLoading ...