Reduction of Serum Cholesterol by Sodium Dextro-thyroxine in Euthyroid Subjects
Authors: NORMAN G. SCHNEEBERG
Journal: Annals of Internal Medicine (1962)

Article1 February 1962Reduction of Serum Cholesterol by Sodium Dextro-thyroxine in Euthyroid SubjectsNORMAN G. SCHNEEBERG, M.D., F.A.C.P., ELTON HERMAN, M.D., HYMAN MENDUKE, PH.D., NORMAN K. ALTSCHULER, M.SC.NORMAN G. SCHNEEBERG, M.D., F.A.C.P.Search for more papers by this author, ELTON HERMAN, M.D.Search for more papers by this author, HYMAN MENDUKE, PH.D.Search for more papers by this author, NORMAN K. ALTSCHULER, M.SC.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-56-2-265 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptIt is well known that thyroid hormones can effect a decline in the level of serum cholesterol (1). The dose required, however, usually causes calorigenic stimulation and an increase in myocardial metabolism, side effects which may be disturbing to subjects free of cardiac disease, and not without danger to patients who have coronary heart disease. Numerous thyroxine analogues have been studied in the hope of finding one whose cholesterol lowering action far exceeds its other hormonal effects. Several reports (2, 3) suggest that dextro-thyroxine (3,5,3′,5′-tetraiodo-D-thyroxine) demonstrates these properties and is the best available analogue at present. Current interest in the...References1. STRISOWERGOFMANGALIONIALMADASIMON BJWEFAAA: Effect of thyroid extract on serum lipoproteins and serum cholesterol. Metabolism 3: 218, 1954. MedlineGoogle Scholar2. BOYDOLIVER GSMF: The effect of certain thyroxine analogues on the serum lipids in human subjects. J. Endocr. 21: 33, 1960. CrossrefGoogle Scholar3. STARRROENFREIBRUNSCHLEISSNER PPLLA: Reduction of serum cholesterol by sodium dextro-thyroxine. Arch. Intern. Med. 105: 830, 1960. CrossrefMedlineGoogle Scholar4. PEARSONSTERNMCGAVACK SSTH: A rapid accurate method for the determination of total cholesterol in serum. J. Analyt. Chem. 25: 813, 1953. CrossrefGoogle Scholar5. RUEGAMER WR: Effects of thyroxine analogues on tissue cholesterol concentrations in rats, in Derivatives and Isomers of the Tyroid Hormone. ed. by Sachs, M. L., Conference of the School of Medicine, University of Pennsylvania, Feb. 5 and 6, 1960. Google Scholar6. BOYDOLIVER GSMF: Thyroid hormones and plasma lipid. Brit. Med. Bull. 16: 138, 1960. CrossrefMedlineGoogle Scholar7. TAPLEY DF: Distribution, excretion and oxygen consumption studies in the rodent, in Symposium on Sodium D-Thyroxine (Paper No. 3), Chicago, December 5, 1959. Abstracted by Kritchevsky, D. Google Scholar8. STARR P: Reduction of serum cholesterol by sodium dextro-thyroxine, in Symposium on Sodium D-Thyroxine (Paper No. 8), Chicago, December 5, 1959, pp. 49-56. Abstracted by Kritchevsky, D. Google Scholar9. GOLDSTEIN MS: Clinical results of D-thyroxine administration, in Symposium on Sodium D-Thyroxine, Chicago, December 5, 1959, pp. 63-66. Abstracted by Kritchevsky, D. Google Scholar10. KRITCHEVSKY D: Influence of thyroid hormones and related compounds on cholesterol biosynthesis and degradation: a review. Metabolism 9: 984, 1960. MedlineGoogle Scholar11. THOMAS CB: Cholesterol characteristics. Maryland Med. J. 8: 2, 1959. Google Scholar12. RIVINYOSHIMOSHICKMANSCHJEIDE AUJMOA: Serum cholesterol measurement—hazards in clinical interpretation. J. A. M. A. 166: 2108, 1958. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Philadelphia, PennsylvaniaSupported by a grant from the Travenol-Baxter Laboratories.Presented at the Section on Internal Medicine, 110th Annual Meeting of the American Medical Association, June 29, 1961.Requests for reprints should be addressed to Norman G. Schneeberg, M.D., 2400 North 54th Street, Philadelphia, Pa. 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LUX, M.D., HOWARD R. SLOAN, M.D., Ph.D., RONALD M. KRAUSS, M.D., PETER N. HERBERT, M.D.Hyperlipoproteinemia and coronary heart diseaseThe Treatment of HyperlipidemiaSelective blood lipid reductions by newer pharmacologic agentsThe status of hormonal therapy for the primary and secondary prevention of atherosclerotic coronary heart diseaseDextro-Thyroxine as a Cholesterol-Lowering Agent in Patients with Angina PectorisThe effect of diet, d-thyroxin and atromid on serum cholesterol and triglycerides in manDextro-Thyroxine and hypercholesterolemia: A clinical studyMetabolic Activity of the D-Isomers of Thyroxine and Tri-Iodothyronine 1 February 1962Volume 56, Issue 2Page: 265-275KeywordsAnginaCholesterolCoronary heart diseaseElectrocardiographyHeart diseasesReflexesSodiumTendonsThyroid hormonesThyroxine Issue Published: 1 February 1962 PDF downloadLoading ...