tbuckley/cabot-search huggingface dataset:
A Comedy of Errors
Authors: Frederic Speer
Journal: JAMA (1966)

<h3>To the Editor:—</h3> In one of their statements about constitutional reactions being followed by a period of refractoriness, the authors refer to Vaughan's text of 1939, which like every other textbook of allergy assumes the efficacy of hyposensitization. The authors have concluded that "it is known" that injections below the constitutional reaction level<i>also</i>confer refractoriness. Their patient follow-up seems to have depended on evaluation by a lay study clerk. Great reliance was placed on symptoms reported by parents and on the number of antihistamine tablets they gave their children. Questions pertaining to accuracy of the symptom cards were referred to the physicians in the clinic who further questioned both child and parent. Nothing is said about physical examination or laboratory procedures. Observations on asthma had to be discarded the first year because patients did not understand that "difficulty in breathing" was supposed to mean asthma. There is no question
Clear ultraviolet blocking lenses for use by PUVA patients
Authors: H. MOSELEY, S.K. JONES
Journal: British Journal of Dermatology (1990)

It is well recognized that patients receiving photochemotherapy (PUVA) need to wear UV-blocking sunglasses on the day of ingestion of 8-methoxypsoralen. For many patients the wearing of tinted sun-glasses causes difficulties because they interfere with colour perception, reduce definition in conditions of low background light and often because they are considered 'cosmetically unacceptable'. In this study the UV-blocking properties of a number of lenses with little or no tint were assessed. The following lenses or lens coatings were found to be suitable for use by PUVA patients: Orcolite UV 400, Orma UVX, Rodenstock Lambda 400, Sola UV Gard 400 and Polaroid polarizing lenses.
Reversible airway obstruction in cystic fibrosis.
Authors: L P Ormerod, R A Thomson, C M Anderson, D E Stableforth
Journal: Thorax (1980)

Fourteen (29%) of 48 children with cystic fibrosis had a greater than 15% improvement in forced expiratory volume in one second, or in forced vital capacity after inhalation of salbutamol. All these children were atopic (one or more positive prick tests) and had a significantly higher mean serum IgE than either non-atopic subjects or those atopic subjects without airways reversibility (p less than 0.02). Half of those with airways reversibility had or subsequently developed the clinical picture of allergic bronchopulmonary aspergillosis. Of the whole group 81% were atopic, of whom 77% had a positive reaction to A fumigatus, 64% to housedust, and 56% each to grass pollen and cat hair. Children who were not atopic had significantly better spirometry (p greater than 0.05) than those who were. Children with skin hypersensitivity to A fumigatus had identical spirometry to those who were atopic without reactivity to A fumigatus. Serum precipitins to A fumigatus were present in 48%. Serum precipitins to pancreatin were present in 71%, but the presence of these precipitins did not correlate with atopy, airways reversibility, or serum IgE.
High molecular weight glycosaminoglycans in AA type amyloid fibril extracts from human liver.
Authors: J H Magnus, S O Kolset, G Husby
Journal: Annals of the Rheumatic Diseases (1991)

Glycosaminoglycans have previously been identified in extracts of AA type hepatic amyloid fibril from a patient with amyloidosis associated with juvenile rheumatoid arthritis. The macromolecular properties of these polysaccharides are described here in more detail. By gel filtration and ion exchange chromatography glycosaminoglycans in the form of high molecular weight free chains were shown to coisolate with water extracted amyloid fibrils. About 60% of these were characterised as galactosamines (chondroitin sulphate/dermatan sulphate), whereas the remaining 40% consisted of N-sulphated glucosamines (heparin/heparan sulphate). The amyloid associated glycosaminoglycans were not part of intact proteoglycans in the fibril extracts.
Immunohistochemical demonstration of chromogranin A, chromogranin B, and secretoneurin in primary non-small-cell carcinomas of the lung
Authors: Martin Tötsch, Birgit Kunk, Barbara Dockhorn-Dworniczak, Dietmar öfner, Reiner Fischer-Colbrie, Gregor Mikuz, Werner Böcker, Kurt Werner Schmid
Journal: Endocrine Pathology (1994)
The SNP276G&gt;T polymorphism in the adiponectin (ACDC) gene is more strongly associated with insulin resistance and cardiovascular disease risk than SNP45T&gt;G in nonobese/nondiabetic Korean men independent of abdominal adiposity and circulating plasma adiponectin
Authors: Yangsoo Jang, Jong Ho Lee, Oh Yoen Kim, Soo Jeong Koh, Jey Sook Chae, Jin Hee Woo, Hongkeun Cho, Jong Eun Lee, Jose M. Ordovas
Journal: Metabolism (2005)
Sensitization to Thyreophagus Entomophagus and other Mite Species in Cuban Patients with Allergic Asthma and/or Rhinoconjunctivitis
Authors: F. de la Torre Morín, R. Aguila de la Coba, M. Gallego, V. Iraola, E. Fernández-Caldas
Journal: Journal of Allergy and Clinical Immunology (2006)
Body Language: 5 East, NIH
Authors: Barbara Seaman
Journal: JAMA (1992)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The clinical and histological spectrum of lymphomatoid papulosis
Authors: R. WILLEMZE, C.J.L.M. MEYER, W.A. VLOTEN, E. SCHEFFER
Journal: British Journal of Dermatology (1982)

A review of sixty-four biopsies from sixteen patients with lymphomatoid papulosis revealed two characteristic histological types (type A and type B), which also had a different clinical behaviour. In lymphomatoid papulosis type A lesions, four histological patterns corresponding with the age of the lesion could be distinguished. Such a relationship was not found in type B lesions. The findings of transitional forms in some biopsy specimens, showing histological features of both type A and type B, and the presence of both types in different but concurrent lesions, suggests that these two types are not different entities but rather represent the ends of a spectrum. At least two different populations of atypical cells can be distinguished in lymphomatoid papulosis. Apart from the atypical cerebriform mononuclear cells, which are T-lymphocytic in origin and predominant in type B lesions, large atypical cells with vesicular nuclei, prominent nucleoli and abundant cytoplasm are found, particularly in type A lesions. Preliminary immunohistochemical and cytochemical investigations suggest that these cells are not lymphoid in origin, but are related to the Langerhans cell series.
Genetic evidence for a tumor suppressor role of HIF-2α
Authors: Till Acker, Antonio Diez-Juan, Julian Aragones, Marc Tjwa, Koen Brusselmans, Lieve Moons, Dai Fukumura, Maria Paz Moreno-Murciano, Jean-Marc Herbert, Angelika Burger, Johanna Riedel, Gerd Elvert, Ingo Flamme, Patrick H. Maxwell, Désiré Collen, Mieke Dewerchin, Rakesh K. Jain, Karl H. Plate, Peter Carmeliet
Journal: Cancer Cell (2005)
Case of Popliteal Aneurysm: Ligature of Femoral Artery
Authors: J. N. Stone
Journal: BMJ (1890)

ment fails in attaining its object.In such cases we would strongly urge that the mastoid cells should be trephined, and all casous matter (which will probably be found) cleare out, and a thorough drainage of the tympanum established.By this method the presence of matter likely to form a focus of secondary infec- tion would be avoided, a return to the local condition of health made possible, and the chances of subsequent intracranial sup- puration considerably reduced.
804-3 The effects of cardiac resynchronization therapy on regional left and right ventricular energetics and metabolic reserve in patients with dilated cardiomyopathy
Authors: Juhani M Knuuti, Jan Sundell, Erik Engblom, Juhani Koistinen, Antti Ylitalo, Kira Q Stolen, Riikka Kalliokoski, Stephan G Nekolla, Jeroen J Bax, Juhani K.E Airaksinen
Journal: Journal of the American College of Cardiology (2004)
Clonality in Langerhans' cell histiocytosis
Authors: F. E Cotter, J. Pritchard
Journal: BMJ (1995)

The more acute problem is the distance that doctors are from their patients.Although most people report that distance is not an obstacle to access, for those most in need, including elderly and disabled people and those dependent on public transport, distance is often an important constraint.The negative effect of distance on the use of general practice services, both at the surgery and at home, has been repeatedly documented over the past 20 years.'I Knox has described how the changes in the locations of general practices in Aberdeen between 1950 and 1973 reinforced the geographical patterns of disadvantage.6(Their amalgamation into group practices and their failure to devolve from city centre to peripheral housing estates made access more rather than less difficult.)Most general practitioners breathe a sigh of relief when new premises are built.Siting, however, is often a parochial affair, dependent on personal preference, the availability of a site,
Functional analysis of human cardiac troponin by the in vitro motility assay: comparison of adult, foetal and failing hearts
Authors: I Purcell
Journal: Cardiovascular Research (1999)

Objective: Human cardiac development and heart failure are associated with altered troponin isoform expression and phosphorylation. As the functional effects of these changes in troponin are unknown, we isolated troponin from human foetal, normal adult and failing adult hearts and investigated their regulatory function. Methods: Human cardiac troponin was assayed for regulatory function by in vitro motility assay and for protein content by SDS PAGE and immunoblotting. Results: Human cardiac troponin regulated movement of actin–tropomyosin filaments over a bed of immobilised heavy meromyosin. At pCa 9, troponin from foetal and adult hearts reduced the fraction of filaments moving from 90% to less than 15% with a modest (25–30%) decrease in velocity. At pCa 5, troponin from normal adult hearts increased filament velocity by up to 47±3% with no change in the fraction of filaments moving. Foetal troponin increased velocity by only 4±6% and the effect of troponin from failing hearts was between these values at 31±5%. Foetal hearts showed different troponin I and T isoform expression compared with adult hearts. No differences in troponin isoform expression were demonstrated between normal and failing adult hearts. Conclusions: Functioning troponin and tropomyosin may be isolated from human heart and their properties investigated by in vitro motility assay. Both functional and isoform expression differences exist between foetal and adult cardiac troponin. The regulatory function of troponin from adults with end stage heart failure is different from normal adult troponin. These data suggest a role for altered troponin function in human cardiac development and heart failure.
A Prevalence Survey of Diabetes in Mauritania
Authors: Michel Ducorps, Serge Baleynaud, Herve Mayaudon, Christian Castagne, Bernard Bauduceau
Journal: Diabetes Care (1996)

To perform an epidemiological study of the prevalence of diabetes in Mauritania, West Africa, with little data available on diabetes in West Africa.The study was performed with a representative sample of the Mauritanian population. A random selection of the study population (n = 744) was drawn by a cluster sampling method. Screening for diabetes was made by capillary blood glucose (CBG) measurement, using strips analyzed by reflectance meter. Criteria for the diagnosis of diabetes were those of the World Health Organization (WHO).The survey performed a screening of 744 subjects whose sex distribution was 307 men and 437 women. Their mean age was 34.6 +/- 15.2 years, and their mean BMI was 22.7 +/- 5.1 kg/m2, with a significant difference for BMI between men (20.0 +/- 2.9 kg/m2) and women (24.3 +/- 5.5 kg/m2). According to the study criteria, we found 14 diabetic patients (4 men, 10 women). The crude prevalence of diabetes was 1.88% (95% CI 0.90-2.86). The difference in prevalence by sex was 1.30% (95% CI 0.00-2.60) for men and 2.29% (95% CI 0.89-3.43) for women. For the truncated 30- to 64-year-old age-group, the crude prevalence was 2.84%; the age-adjusted prevalence for the same 30- to 64-year-old age-group, using the standardized age distribution of Segi (10), was 2.61%.With a crude prevalence of diabetes of 1.88% and an age-adjusted prevalence of 2.61%, Mauritania may be classified among the countries with a low prevalence of diabetes, a finding which is not surprising, considering the low level of development of this region of Africa.
Release of calcium from guinea pig cardiac sarcoplasmic reticulum induced by sodium-calcium exchange
Authors: P. C Levesque, N. Leblanc, J. R Hume
Journal: Cardiovascular Research (1994)

Objective: Depolarisation-induced Na+ influx through tetrodotoxin sensitive Na+ channels causes a rapid increase in intracellular Ca2+ concentration ([Ca2+]i). The Na+ current (INa) induced [Ca2+]i transients: (a) occur after blocking sarcolemmal Ca2+ channels with nisoldipine or D-600, (b) are inhibited by ryanodine, and (c) are dependent upon extracellular Ca2+. Thus the INa induced [Ca2+]i transients arise from sarcoplasmic reticular Ca2+ release triggered by Ca2+ entering the myocyte, following a transient rise in intracellular Na+ ([Na+]i), via a pathway distinct from sarcolemmal Ca2+ channels. Reverse mode Na+-Ca2+ exchange could provide such a pathway for Ca2+ entry. The aim of this study was to ascertain directly whether Na+-Ca2+ exchange mediates the INa induced release of Ca2+ from sarcoplasmic reticulum. Methods: Whole cell voltage and current clamped guinea pig ventricular myocytes dialysed with indo-1 were used; Ca2+ transients elicited upon activation of INa before and after inhibiting the exchanger were measured. Results: Following conditioning protocols to load Ca2+ stores, activation of INa during a test pulse to −50 mV from a holding potential of −80 mV elicited [Ca2+]i transients in caesium loaded myocytes superfused with solutions containing 2.5 mM Ca2+ and 5 μM nisoldipine. When extracellular Na+ was replaced with equimolar lithium, which carries current through Na+ channels but does not readily substitute for Na+ on the Na+-Ca2+ exchanger, or when Ni2+ (5 mM) or dichlorobenzamil (10 μM), which block the exchanger, were added to superfusion solutions, activation of INa failed to elicit [Ca2+]i transients. Lithium and Ni2+ also inhibited nisoldipine insensitive [Ca2+]i transients elicited by action potentials, indicating that INa and Na+-Ca2+ exchange may play a role in excitation-contraction coupling under physiological conditions. Conclusions: Activation of INa appears to promote Ca2+ entry into cardiac cells by stimulation of reverse mode Na+-Ca2+ exchange, triggering Ca2+ release from the sarcoplasmic reticulum.
Retrograde concealed conduction in the atrioventricular node: differential manifestations related to level of intranodal penetration.
Authors: M H Lehmann, R Mahmud, S Denker, J Soni, M Akhtar
Journal: Circulation (1984)

Although concealed conduction in the atrioventricular node (AVN) has been the focus of numerous experimental and clinical studies, little is known about the differential effects on AVN functional behavior of prior concealed retrograde impulse penetration alone vs prior anterograde or dual AVN activation. This study was undertaken specifically to investigate this aspect of human AVN physiology in patients without intact ventriculoatrial conduction to provide a model with which to analyze concealed retrograde AVN conduction. In 13 such patients AVN behavior during a subsequent anterograde input was characterized for each of three different manners of prior AVN activation: anterograde alone (method I), simultaneous anterograde and retrograde excitation (method II), or equivalently timed retrograde concealed AVN penetration alone (method III). In all patients evidence for retrograde AVN concealment was documented by longer anterograde conduction in the AVN during method III than that observed when the retrograde impulse was omitted (method IV). Furthermore, in these patients lacking intact ventriculoatrial conduction, anterograde conduction in the AVN was facilitated and refractoriness was decreased during dual excitation vs anterograde activation alone (method II vs method I). However, when each of methods I and II were compared with concealed retrograde AVN penetration alone (method III), two patterns of AVN responses were observed: In 11 of 13 patients (group A) conduction in the AVN was "worse" and refractoriness was greater both in methods I and II compared with method III; in the remaining two patients (group B) the opposite relationships were observed. The results suggest that among patients with no ventriculoatrial AVN conduction there exist at least two subpopulations whose AVN functional characteristics differ markedly when the effects of anterograde and dual excitation are compared with equivalently timed concealed retrograde activation alone. These findings may be related to differences in level of retrograde AVN concealment in groups A and B, which can be unmasked by the outlined pacing techniques.
Is It Obvious Why Patients Ask Questions?
Authors: Joseph R. Glaser
Journal: JAMA (1976)

THE QUESTIONS that patients put to their physicians are more than unilevel in meaning. On the one hand, they deal with the reality factors of being ill; on the other, they involve root problems of dependency, potency, shame, guilt, and self-awareness. The question "Why did all this happen to me?" reiterated from the book of Job is often dismissed as a philosophical or theological dilemma. Nothing human is outside the scope of medicine. An analysis and attempt to answer this question is a useful introduction to the human process of becoming ill. Complementary to the molecular disturbances involved in illness and aging, a similar homologous disruption is occurring at a psychological level. Stable psychic structures are called into question. Previous self-images are no longer coherent and consistent. Job was a righteous man and offered sacrifice daily to God, but still he lost his possessions and became ill with a skin
Expression of Heparanase in Renal Cell Carcinomas: Implications for Tumor Invasion and Prognosis
Authors: Shuji Mikami, Mototsugu Oya, Masayuki Shimoda, Ryuichi Mizuno, Masaru Ishida, Takeo Kosaka, Makio Mukai, Motowo Nakajima, Yasunori Okada
Journal: Clinical Cancer Research (2008)

Heparanase activity has been detected in many malignant tumors, showing a correlation with the metastatic potential. The present study was undertaken to investigate the expression of heparanase and its prognostic significance in renal cell carcinomas (RCC).Nineteen RCCs and 6 nonneoplastic renal tissues were analyzed for heparanase mRNA expression by real-time PCR. Heparanase protein expression was semiquantitatively investigated by immunohistochemistry in 70 RCCs. Involvement of heparanase in the invasiveness of RCC cell lines, 786-O and Caki-2 cells, was examined by down-regulating the gene expression with small interfering RNA (siRNA) using the Matrigel invasion assay.The expression level of heparanase mRNA was significantly higher in clear cell RCCs than in papillary RCCs, chromophobe RCCs, and nonneoplastic renal tissues. Heparanase was predominantly immunolocalized to cell surface and cytoplasm of clear cell RCCs and mean expression levels of heparanase were significantly higher in clear cell RCCs than in papillary and chromophobe RCCs. The protein expression levels were positively correlated with primary tumor stage, distant metastasis, and histologic grade. Targeting of heparanase mRNA expression in 786-O and Caki-2 cells with siRNA down-regulated the mRNA expression and inhibited the Matrigel invasion by these cells, whereas nonsilencing siRNA showed no effect. Multivariate Cox analysis revealed that elevated heparanase expression was a significant and an independent predictor of disease-specific survival (odds ratio, 8.814; P = 0.019).These data suggest that heparanase plays an important role in invasion and metastasis and silencing of the gene might be a potential therapeutic target in clear cell RCCs.
CORONARY CALCIFICATION IN HIV-INFECTED PATIENTS, ASSESSED BY CORONARY ARTERY CALCIUM SCORE (CACS): THE VIHCAC STUDY
Authors: Romain Chopard, Adeline Foltzer, Jerome Jehl, Christine Drobacheff-Thiebaut, Catherine Chirouze, Laurent Hustache-Mathieu, Helder Gil, Jean-Pierre Faller, Bruno Kastler, Bruno Hoen, Francois Schiele
Journal: Journal of the American College of Cardiology (2011)
THERAPEUTIC VALUE AND EFFECTS OF AMNIOTIN IN GONORRHEAL VAGINITIS IN CHILDREN
Authors: JOHN HUBERMAN
Journal: JAMA (1934)

The serious problem of gonorrheal vaginitis in children has been brought nearer to solution by the ingenious application of a safe and efficient method of treatment, demonstrated by Robert M. Lewis. We are of the opinion that this new radical treatment may convert what was formerly a serious social and economic problem into a mild and controlled medical syndrome.  Edgar Allen in 1928 clearly demonstrated that after the injection of 1,005 rat units of ovarian hormone into immature female monkeys, over a period of twenty-one days, there was a definite increase in the number of epithelial layers of the vagina to thirty, as compared to from four to eight layers in the control animal. Associated with these changes, the vaginal smears showed an increased number of partly or completely cornified epithelial cells. Allen further showed that involution of the vaginal structures occurred several weeks subsequent to the cessation of the