NEUTROPENIA ASSOCIATED WITH SPLENOMEGALY AND ATROPHIC ARTHRITIS (FELTY'S SYNDROME): REPORT OF A CASE IN WHICH SPLENECTOMY WAS PERFORMED
Authors: H M ROGERS, F H LANGLEY
Journal: Annals of Internal Medicine (1950)

Case Reports1 April 1950NEUTROPENIA ASSOCIATED WITH SPLENOMEGALY AND ATROPHIC ARTHRITIS (FELTY'S SYNDROME): REPORT OF A CASE IN WHICH SPLENECTOMY WAS PERFORMEDH. MILTON ROGERS, M.D., F.A.C.P., FRANCIS H. LANGLEY, M.D.H. MILTON ROGERS, M.D., F.A.C.P.Search for more papers by this author, FRANCIS H. LANGLEY, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-32-4-745 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe syndrome of atrophic polyarthritis occurring in an adult, associated with fever, secondary anemia, leukopenia and splenomegaly, was described by Felty1in 1924. Chevallier2suggested in 1930 that splenectomy might produce relief of the arthritis in Felty's syndrome. This surgical procedure, however, was not performed until 1932, when Hanrahan and Miller3reported the first case of Felty's syndrome in which splenectomy was performed for the neutropenia and splenomegaly. Subsequent cases of the syndrome under discussion in which splenectomy was performed were reported by Craven4; Reich5; Bloem, van Creveld, Kuipers and Zuidema6; Steinberg7; Gyntelberg8; Trolle and Trolle9; Dameshek10; Zimmer11; Hirschboeck12(two...Bibliography1. Felty AR: Chronic arthritis in the adult, associated with splenomegaly and leucopenia; a report of five cases of an unusual clinical syndrome, Bull. Johns Hopkins Hosp. 35: 16-20, 1924. Google Scholar2. Chevallier MP: La maladie de Chauffard-Still et les syndromes voisins, Rev. de méd., Paris 47: 77-130, 1930. Google Scholar3. HanrahanMiller EMSR: Effect of splenectomy in Felty's syndrome, J. A. M. A. 99: 1247-1249, 1932. CrossrefGoogle Scholar4. Craven EB: Splenectomy in chronic arthritis associated with splenomegaly and leukopenia (Felty's syndrome), J. A. M. A. 102: 823-826, 1934. CrossrefGoogle Scholar5. Reich C: A case of Felty's syndrome, M. Rec. 144: 448, 1936. Google Scholar6. Bloemvan CreveldKuipersZuidema TFSFCPJ: De Syndromen van Still, Chauffard-Ramond en Felty, Nederl. tijdschr. v. geneesk. 81: 5601-5609, 1937. Google Scholar7. Steinberg CL: The value of splenectomy in Felty's syndrome, Ann. Int. Med. 17: 26-40, 1942. LinkGoogle Scholar8. Gyntelberg I: Et Tilfaelde af Felty's Syndrom behandlet med Splenectomia, Nord. med. 13:927-930, 1942. Google Scholar9. TrolleTrolle ED: To sjaeldne splenomegaliformer: polyarthroitis chronica cum splenomegalia (Felty's syndrom) og cystis lienis non-parasitica, Nord. med. 18: 761-766, 1943. Google Scholar10. Dameshek W: Leukopenia. In Christian, H. A.: The Oxford Medicine, New York, Oxford University Press, 1944, vol. 2, pt. 3, chap. 22, pp. 841-848(14); Agranulocytosis, chap. 22-A, pp. 848(15)-484(66). Google Scholar11. Zimmer J: Felty's syndrome: splenomegalia, leucopenia and chronic polyarthritis—familial occurrence, Acta med. Scandinav. 120: 543-567, 1945. CrossrefGoogle Scholar12. Hirschboeck JS: Hematologic effects of splenectomy in Still-Chauffard-Felty syndrome; report of 2 cases, Blood 1: 247-255, 1946. CrossrefMedlineGoogle Scholar13. Doan CA: Pan-marrow hematopoiesis (L. casei factor) and splenic hematopenia; experimental and clinical studies. Fifth Edwin R. Kretschmer Memorial Lecture, Apr. 26, 1946. Google Scholar14. Bauer E: Ueber die Wirkung der sogenannten Fixationsabscesse, Virchow's Arch. f. path. Anat. 156: 529-565, 1899. CrossrefGoogle Scholar15. Eppinger H: Zur Pathologie der Milzfunktion, Berl. klin. Wchnschr. 50: 1509-1512; 1572-1576; 2409-2411, 1913. Google Scholar16. WisemanDoan BKCA: A newly recognized syndrome caused by excessive splenic leukolysis and successfully treated by splenectomy, J. Clin. Investigation 18: 473, 1939. Google Scholar17. WisemanDoan BKCA: Primary splenic neutropenia; a newly recognized syndrome, closely related to congenital hemolytic icterus and essential thrombocytopenic purpura, Ann. Int. Med. 16: 1097-1117, 1942. LinkGoogle Scholar18. SalzerRansohoffBlatt MJLH: Primary splenic neutropenia, with report of a case, Ann. Int. Med. 22: 271-273, 1945. LinkGoogle Scholar19. RogersHall HMBE: Primary splenic neutropenia, Arch. Int. Med. 75: 192-196, 1945. CrossrefGoogle Scholar20. LangstonWhiteAshley WOAJD: Splenic neutropenia: report of a case with splenectomy, Ann. Int. Med. 23: 667-672, 1945. LinkGoogle Scholar21. Levy H: Granulocytopenic and lymphocytopenic hypersplenism associated with atrophic arthritis, Acta med. Scandinav. 129: 203-212, 1947. CrossrefGoogle Scholar22. Doan CA: Personal communication to the authors. Google Scholar23. Williams RH: Felty's syndrome; report of a case with necropsy findings, Ann. Int. Med. 9: 1247-1255, 1936. LinkGoogle Scholar24. MooreBierbaum CVOS: Chronic neutropenia treated by splenectomy, Internat. Clin. n.s.2, 3: 86-95, 1939. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: H. MILTON ROGERS, M.D., F.A.C.P.; FRANCIS H. LANGLEY, M.D.Affiliations: St. Petersburg, Florida*Received for publication October 12, 1948. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byFelty's syndrome without rheumatoid arthritis?The spleen in Felty's syndrome: A histological, morphometrical, and immunohistochemical study111Indium-labelled white blood cells in the diagnosis of Felty's syndrome.Felty syndromeThe rarity of felty's syndrome in blacksHaematological Changes in Rheumatoid DiseaseNeutropenia, Elevated Rheumatoid Factor, Splenomegaly, and Absence of Rheumatoid ArthritisG. G. CORNWELL III, M.D., L. R. ZACHARSKI, M.D.Hautmanifestationen rheumatischer KrankheitenThe variable features of Felty's syndromeIndikationen zur Splenektomie bei BlutkrankheitenFELTY'S SYNDROMEDermatologische Ver�nderungen beim Felty-SyndromDestruction of the Superior Maxilla in Felty's SyndromeTherapy of "Felty's Syndrome"Haematological Findings in SplenomegalyRHEUMATISM AND ARTHRITIS REVIEW OF AMERICAN AND ENGLISH LITERATURE OF RECENT YEARS (TENTH RHEUMATISM REVIEW)* Part IIWILLIAM D. ROBINSON, M.D., F.A.C.P., EDWARD W. BOLAND, M.D., F.A.C.P., JOSEPH J. BUNIM, M.D., F.A.C.P., DARRELL C. CRAIN, M.D., F.A.C.P., EPHRAIM P. ENGLEMAN, M.D., F.A.C.P., WALLACE GRAHAM, M.D., F.R.C.P. (C), L. MAXWELL LOCKIE, M.D., F.A.C.P., MAX M. MONTGOMERY, M.D., F.A.C.P., CHARLES RAGAN, M.D., F.A.C.P., MARIAN W. ROPES, M.D., F.A.C.P., EDWARD F. ROSENBERG, M.D., F.A.C.P., CHARLEY J. SMYTH, M.D.SPLENECTOMY IN RHEUMATOID ARTHRITIS*CHARLES LEROY STEINBERG, B.S., M.D., F.A.C.P.Die Panmyelophthise und verwandte Zustände der Knochenmarksinsuffizienz 1 April 1950Volume 32, Issue 4Page: 745-754KeywordsArthritisBloodBlood countsFelty syndromeHemoglobinLymphocytesMonocytesNeutropeniaSplenectomySplenomegaly ePublished: 1 December 2008 Issue Published: 1 April 1950 PDF downloadLoading ...