Disseminated Malignant Lymphoma, Histiocytic Type: The Changing Picture
Authors: D L Sweet, H M Golomb, J E Ultmann
Journal: Annals of Internal Medicine (1976)

Editorials1 October 1976Disseminated Malignant Lymphoma, Histiocytic Type: The Changing PictureDONALD L. SWEET JR., M.D., HARVEY M. GOLOMB, M.D., JOHN E. ULTMANN, M.D., F.A.C.P.DONALD L. SWEET JR., M.D.Search for more papers by this author, HARVEY M. GOLOMB, M.D.Search for more papers by this author, JOHN E. ULTMANN, M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-85-4-521 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptIn this month's issue, Schein and associates (p. 417) report on their successful experience with BACOP (bleomycin, Adriamycin®, cyclophosphamide, Oncovin® [vincristine], and prednisone) combination chemotherapy in the management of patients with advanced histiocytic lymphoma. Nearly one half of previously untreated patients achieved a complete remission as defined by rigorous restaging criteria. Many of these patients may have been cured. The data of Schein and colleagues at the National Cancer Institute add substantially to the notion that malignant lymphoma, histiocytic diffuse type—once an invariably fatal disorder—is now a very treatable and perhaps curable disease. This revolution in the therapy of histiocytic...References1. RAPPAPORT H: Tumors of the hematopoietic system, in Atlas of Tumor Pathology, Section 3, Fasc 8. Washington, D.C., Armed Forces Institute of Pathology, 1966 Google Scholar2. JONESROSENBERGKAPLAN SSH: Non-Hodgkin's lymphomas. II. Single agent chemotherapy. Cancer 30:31-38, 1972 CrossrefMedlineGoogle Scholar3. CARBONESPURRSCHNEIDERMAN PCM: Management of patients with malignant lymphoma: A comparative study with cyclophosphamide and vinca alkaloids. Cancer Res 28:811-822, 1968 MedlineGoogle Scholar4. SKIPPERSCHABELWILCOX HFW: Experimental evaluation of potential anticancer agents. III. On the criteria and kinetics associated with "curability" of experimental leukemia. Cancer Chemother Rep 35:1-111, 1964 MedlineGoogle Scholar5. MENDELSONBLOCKSERPICK DJA: Effect of large intermittent intravenous doses of cyclophosphamide in lymphoma. Cancer 25:715-720, 1970 CrossrefMedlineGoogle Scholar6. DEVITASERPICKCARBONE VAP: Combination chemotherapy in the treatment of advanced Hodgkin's disease. Ann Intern Med 73:881-895, 1970 LinkGoogle Scholar7. LEVITTMARSHDECONTI MJR: Combination sequential chemotherapy in advanced reticulum cell sarcoma. Cancer 29:630-636, 1972 CrossrefMedlineGoogle Scholar8. BERDCORNOGDECONTI DJR: Long-term remission in diffuse histiocytic lymphoma treated with combination sequential chemotherapy. Cancer 35:1050-1054, 1975 CrossrefMedlineGoogle Scholar9. SWEETGOLOMBDESSER DHR: Treatment of advanced histiocytic lymphoma with C.O.M.A. chemotherapy (abstract). Proc Am Assoc Cancer Res 17:10, 1976; and unpublished data Google Scholar10. DEVITACANELLOSCHABNER VGB: Advanced diffuse histiocytic lymphoma, a potentially curable disease. Results with combination chemotherapy. Lancet 1:248-250, 1975 CrossrefMedlineGoogle Scholar11. DURANTLOEBDORFMAN JVR: 1,3-Bis(2-chloroethyl)-1-nitrosourea(BCNU), cyclophosphamide, vincristine-, and prednisone-(BCOP). A new therapeutic regimen for diffuse histiocytic lymphoma. Cancer 36:1936-1944, 1975 CrossrefMedlineGoogle Scholar12. MCKELVEY E: Personal communication Google Scholar13. BITRANSWEETKINZIE JDJ: Survival in localized diffuse histiocytic lymphoma (abstract). Proc Am Assoc Cancer Res 17:240, 1976 Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Department of Medicine The Franklin McLean Memorial Research Institute * Cancer Research Center The University of Chicago Chicago, Illinois*Operated by The University of Chicago for the U.S. Energy Research and Development Administration under Contract No. E( 11-1)-69. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byKlinik der malignen Lymphome 1 October 1976Volume 85, Issue 4Page: 521-523KeywordsCombination chemotherapyCyclophosphamideDiffuse large B-cell lymphomaLymphoma ePublished: 1 December 2008 Issue Published: 1 October 1976 PDF downloadLoading ...