STUDIES RELATING VITAMIN C DEFICIENCY TO RHEUMATIC FEVER AND RHEUMATOID ARTHRITIS; EXPERIMENTAL, CLINICAL, AND GENERAL CONSIDERATIONS*
Authors: JAMES F. RINEHART
Journal: Annals of Internal Medicine (1935)

Article1 November 1935STUDIES RELATING VITAMIN C DEFICIENCY TO RHEUMATIC FEVER AND RHEUMATOID ARTHRITIS; EXPERIMENTAL, CLINICAL, AND GENERAL CONSIDERATIONSI. RHEUMATIC FEVERJAMES F. RINEHART, M.D.JAMES F. RINEHART, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-9-5-586 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptOn the basis of experimental data previously reported1, 2 the concept was presented that rheumatic fever may be the result of the combined influence of vitamin C deficiency and infection. It is the purpose of this communication briefly to review this and to summarize further confirmatory experimental observations and other data accumulated during the past three years that would appear to support this thesis.Experimental Method. The methods employed are essentially similar to those reported.1, 2Guinea pigs were maintained on a basic diet adequate in all food factors except vitamin C. Regulating the intake of vitamin C by giving...References1. RINEHARTMETTIER JFSR: The heart valves and muscle in experimental scurvy with superimposed infection. With notes on the similarity of the lesions to those of rheumatic fever, Am. Jr. Path., 1934, x, 61-79. Google Scholar2. RINEHARTCONNORMETTIER JFCLSR: Further observations on pathologic similarities between experimental scurvy combined with infection and rheumatic fever, Jr. Exper. Med., 1934, lix, 97-114. CrossrefGoogle Scholar3. POYNTONSCHLESINGER FJB: Recent advances in the study of rheumatism, 1931, P. Blakiston's Son and Co., Inc., Philadelphia. Google Scholar4. RIBBERT H: Die Erkrankungen des Endokards. Handbuch der speziellen pathologischen Anatomie und Histologie, by HENKE and LUBARSCH, Julius Springer, Berlin, 1924, ii, 217. Google Scholar5. 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Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: San Francisco, California*Read at the Philadelphia meeting of the American College of Physicians, May 1, 1935.This work has been made possible by research funds granted from the Christine Breon Fund for Medical Research.The second and final part of Dr. Rinehart's article will be published in the December number of the ANNALS. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByStreptococcal PharyngitisStreptococcal PharyngitisVitamin C and Infectious DiseasesDie Pathologie der Avitaminosen und HypervitaminosenThe administration of vitamin C in a large institution and its effect on general health and resistance to infectionRHEUMATIC HEART DISEASEReport on the Epidemiology of Rheumatic Infection in South AustraliaTHE INFLUENCE OF VITAMIN DEFICIENCIES ON OTHER DISEASES*JOHN B. YOUMANS, M.D., F.A.C.P.The follicular lesions of vitamine a and c deficiencies: a critical surveySCURVY AND CARDITISTHE PROBLEM OF RHEUMATISM AND ARTHRITIS REVIEW OF AMERICAN AND ENGLISH LITERATURE FOR 1935* (Third Rheumatism Review)PHILIP S. HENCH, M.D., F.A.C.P., WALTER BAUER, M.D., F.A.C.P., A. ALMON FLETCHER, M.D., DAVID GHRIST, M.D., F.A.C.P., FRANCIS HALL, M.D., F.A.C.P.,, T. PRESTON WHITE, M.D.Rheumatic fever in northern CaliforniaSTUDIES RELATING VITAMIN C DEFICIENCY TO RHEUMATIC FEVER AND RHEUMATOID ARTHRITIS; EXPERIMENTAL, CLINICAL AND GENERAL CONSIDERATIONS*II. RHEUMATOID (ATROPHIC) ARTHRITISJAMES F. RINEHART, M.D. 1 November 1935Volume 9, Issue 5Page: 586-599KeywordsDietEatingGuinea pigsResearch designResearch fundingResearch grantsRheumatic feverRheumatoid arthritisVitamin C Issue Published: 1 November 1935 PDF DownloadLoading ...