Androgen Role in Erythroleukemia After Treatment with Alkylating Agents
Authors: B. WlNFRED RUFFNER
Journal: Annals of Internal Medicine (1974)

Letters1 July 1974Androgen Role in Erythroleukemia After Treatment with Alkylating AgentsB. WlNFRED RUFFNER, M.D.B. WlNFRED RUFFNER, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-81-1-118 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: The development of acute myelomoncytic leukemia after treatment with alkylating agents is being reported with increasing frequency. This letter concerns a patient in whom concomitant treatment with androgens may have influenced the course of her disease. Four other reports of androgen and alkylating agent therapy preceding acute leukemia are also cited.In 1963 the patient underwent radical mastectomy for infiltrating ductal carcinoma, with metastasis to axillary nodes. She was 30 years old at that time. After surgery she received prophylactic radiotherapy to the chest wall and axillary, internal mammary, and supraclavicular areas.In 1965 pulmonary metastases were...References1. KENNEDYGILBERTSEN BA: Increased erythropoiesis induced by androgenic-hormone therapy. N Engl J Med 256:719-726, 1957 CrossrefMedlineGoogle Scholar2. DELAMOREGEARY IC: Aplastic anaemia, acute myeloblastic leukaemia, and oxymetholone. Br Med J 2:743-745, 1971 CrossrefMedlineGoogle Scholar3. OSSERMAN E: Monocytic and monomyelocytic leukaemia with increased serum and urine lysozyme as a late complication in plasma cell myeloma. Ibid., p. 327 Google Scholar4. KYLEPIERREBAYRD RRE: Multiple myeloma and acute myelomonocytic leukemia. N Engl J Med 283:1121-1125, 1970 CrossrefMedlineGoogle Scholar5. DAVISPROUTMCKENNA HMP: Acute leukemia complicating metastatic breast cancer. Cancer 31:543-546, 1973 CrossrefMedlineGoogle Scholar6. HAITGORSHEINJEPSON WDJ: 19-nortestosterone decanoate induced erythropoiesis in the actinomycin-D-treated hyperoxic mouse. Biochem Biophys Res Commun 47:426-431, 1972 CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: B. WlNFRED RUFFNER, M.D.Affiliations: Department of Internal Medicine School of Medicine Charlottesville, Virginia 22901 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byToxicity of thiotepa on mouse spermatogenesis as determined by dual-parameter flow cytometryThiono compounds. 4. In vitro mutagenic and antineoplastic activity of TEPA and thio-TEPAAcute Myeloblastic Leukemia after Adjuvant Chemotherapy with Melphalan in Breast Cancer. Case Report with Cytogenetic AnalysisOccurrence of second tumors in man after anticancer drug treatmentEmergence of Acute Non-Lymphocytic Leukemia in Breast Cancer PatientsChemically induced leukemia in humans.Reprocessing of Spent Nuclear FuelsErythroleukemia following drug induced hypoplastic anemiaHodgkin's disease terminating in oat cell carcinoma of the lungBreast cancer and acute leukemia: Report of 24 cases and review of the literatureAcute Leukemia after Alkylating-Agent Therapy of Ovarian CancerThe action of antitumor agents: A double-edged sword?Toxicity of Antineoplastic Agents in Man: Chromosomal Aberrations, Antifertility Effects, Congenital Malformations, and Carcinogenic Potential 1 July 1974Volume 81, Issue 1Page: 118-119KeywordsAcute myeloid leukemiaAndrogensSurgeryThorax ePublished: 1 December 2008 Issue Published: 1 July 1974 PDF downloadLoading ...