THE CLINICAL APPLICATION OF PITUITARY ADRENOCORTICOTROPIC AND ADRENAL STEROID HORMONES
Authors: L W KINSELL
Journal: Annals of Internal Medicine (1951)

Article1 September 1951THE CLINICAL APPLICATION OF PITUITARY ADRENOCORTICOTROPIC AND ADRENAL STEROID HORMONESLAURANCE W. KINSELL, M.D., F.A.C.P.LAURANCE W. KINSELL, M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-35-3-615 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptBACKGROUND AND FUNDAMENTAL CONCEPTSThe history of the pituitary-adrenal system, at least from the standpoint of the clinical physiologist, may be divided arbitrarily into three periods. Thefirstbegan with the masterly description by Thomas Addison1in 1855 of the disease which has since borne his name, and with the demonstration a year later by Brown-Séquard2that extirpation of the adrenals in laboratory animals resulted in the death of the animals. Thesecond, or period of intensive experimentation, had its inception with the demonstration in 1927, by Hartman, MacArthur and Hartman,3and by Rogoff and Stewart,4independently, that adrenal cortical...Bibliography1. Addison T: On the constitutional and local effects of disease of the suprarenal capsules, 1855, S. Highley, London. Google Scholar2. Brown-Séquard E: La physiologie et la pathologie des capsules surrenales, Arch. gén. de méd. 8: 385, 1856. Google Scholar3. HartmanMacArthurHartman FACGWE: A substance which prolongs the life of adrenalectomized cats, Proc. Soc. Exper. Biol. and Med. 25: 69, 1927. CrossrefGoogle Scholar4. RogoffStewart JMGN: The influence of adrenal extracts on the survival period of adrenalectomized animals, Science 66: 327, 1927. CrossrefMedlineGoogle Scholar5. 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Author, Article, and Disclosure InformationAffiliations: Oakland, California*Morning Lecture, presented at the Thirty-second Annual Session of the American College of Physicians, St. Louis, Mo., April 11, 1951.From the Institute for Metabolic Research, Highland Alameda County Hospital, Oakland, California.Any original work here reported represents the combined work of the author and his co-workers, including Lenore Boling, M.D., Sheldon Margen, M.D., George D. Michaels, Ph.D., and John W. Partridge, M.D., aided by the following technical assistants: Carl T. Anderson, Nancy C. Dawson, E. Rosalie Greer, Eleanor E. Kipp, Judith M. Lange, Gerald Liebert, Nancy J. McKillican, Florence Olson and Sadie Smyrl.Grateful acknowledgment is made to Dr. Edward Henderson, Medical Director of Schering Corporation, for supplies of testosterone propionate; to Dr. John Mote, Assistant General Manager of the Armour Laboratories, for supplies of ACTH; to Dr. Augustus Gibson, Executive Director of the Medical Division of Merck & Company, for supplies of cortisone; and to Dr. Warren Cox, Director of Research of the Mead Johnson Research Laboratories, for supplies of Lonalac which have been used in some of the studies here reported. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byThe management of tuberculous meningitis.Subacute and Chronic Granulomatous ThyroiditisCorticosteroids as an adjuvant to the chemotherapy of tuberculous meningitisMorbus ReiterPrednisone for Treatment of Subacute ThyroiditisSUBACUTE GRANULOMATOUS THYROIDITIS: A REVIEW*FRANZ U. 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PARTRIDGE, M.D., LENORE BOLING, M.D., SHELDON MARGEN, M.D.The Effect of ACTH on Gastric Secretion in Experimental Animals 1 September 1951Volume 35, Issue 3Page: 615-651KeywordsAdrenocorticotropic hormonePropionatesResearch laboratoriesSteroid hormonesTestosterone ePublished: 1 December 2008 Issue Published: 1 September 1951 PDF downloadLoading ...