tbuckley/cabot-search huggingface dataset:
Scanning the field of neuroradiology
Authors: P. Gunby
Journal: JAMA (1983)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
General Medical Care and the Education of Internists in University Hospitals
Authors: Jacqueline Kosecoff, Arlene Fink, Robert H. Brook, Allyson Ross Davies, George Goldberg, Lawrence S. Linn, Virginia A. Clark, Pamela C. Salisbury
Journal: Annals of Internal Medicine (1985)

Abstract Fifteen general internal medicine group practices in university teaching hospitals were studied to evaluate their primary care services and education. Data were collected over 9 months fro...
Synphilin-1 associates with α-synuclein and promotes the formation of cytosolic inclusions
Authors: Simone Engelender, Zachary Kaminsky, Xin Guo, Alan H. Sharp, Ravi K. Amaravi, John J. Kleiderlein, Russell L. Margolis, Juan C. Troncoso, Anthony A. Lanahan, Paul F. Worley, Valina L. Dawson, Ted M. Dawson, Christopher A. Ross
Journal: Nature Genetics (1999)
Abstract 15963: Toward Development of a Genetic Risk Score for Sudden Cardiac Death
Authors: Adriana Huertas-Vazquez, Christopher P Nelson, Janet S Sinsheimer, Kyndaron Reinier, Audrey Uy-Evanado, Carmen Teodorescu, Jo Ayala, Karen Gunson, Janathan Jiu, Peter S Braund, Panos Deloukas, Alistair S Hall, Anthony J Balmforth, Nilesh J Samani, Sumeet S Chugh
Journal: Circulation (2014)

Introduction:  Genome-wide association studies have identified multiple common variants associated with risk of SCD. However, independently these loci make modest contributions to disease risk. The objective of this study was to develop a genetic risk score (GRS) for SCD to evaluate the cumulative effects of these variants on SCD risk.   Methods:  We identified variants with established associations to SCD (14 SNPs). To these we added SNPs associated with intermediate phenotypes of SCD including those involved in cardiac ventricular conduction (QRS duration, 26 SNPs), repolarization (QT interval, 9 SNPs) and heart rate (18 SNPs). After quality control, a total of 67 SNPs were investigated. The GRS was calculated using the weighted approach based on the number of risk alleles weighted by the beta coefficients derived from the original studies. GRSs were tested for association using logistic regression models. A total of 966 cases from an ongoing prospective community-based evaluation of SCD in a large U.S. community and 1,926 subjects with coronary artery disease (CAD) from the Wellcome Trust Case Control Consortium (WTCCC+) were included in this study.   Results:  The highest increased risk of SCD was observed with the combination of two previously associated SCD SNPs, rs3010396 within  CASQ2  and rs6730157 within  RAB3GAP1  (OR= 2.43 [1.8-3.2], P=7.41x10 -10 ). CASQ2 and RAB3GAP1 have been previously implicated in calcium signaling and heart disease. Modest associations were found for a GRS composed of 14 SCD SNPs (OR=1.17 [1.05-1.29], P= 0.002). The results remained significant after adjusting for multiple testing. We did not observe significant associations for SNPs linked to the other investigated traits, for individual loci or the overall combined risk score.   Conclusions:  These findings suggest that the cumulative effects of SCD-associated gene variants may contribute to improved SCD prediction. Additional studies of cumulative genetic risk in larger, well-phenotyped populations are warranted.
Abstract 3876: Can Nanog activity identify aggressive breast cancer stem cell populations
Authors: Thomas J. Sayers, Rachel de Kluyver, Marcella Kaddoura, Jim Stauffer, Poonam Tewary, Alan D. Brooks
Journal: Cancer Research (2014)

Abstract Many tumors have been demonstrated to contain cancer stem cells (CSC). We hypothesized that expression of transcription factors that are required for induction and maintenance of pluripotency would be a possible alternative to cell surface phenotype for identification of CSC populations. Therefore we evaluated Nanog expression in 4T1.2 murine breast carcinoma cells, as a biomarker for CSC sub-populations. Introduction of a Nanog promoter reporter that drives destabilized GFP into 4T1.2 cells resulted in a stable expression of GFP in about 1-3% of the cells. On in vitro cell culture of FACS sorted GFP+ populations, up to 80% of the cells became GFP- over a period of 4 weeks, whereas GFP- populations remained 100% GFP-. In vitro CSC surrogate assays show that Nanog-GFP+ cells exhibited CSC characteristics, with enhanced colony formation in methylcellulose and increased survival in serum-free media. Nanog-GFP+ cells were also more efficient at generating experimental lung metastases following intravenous injection. In addition Nanog-GFP+ cells were also more resistant to the chemotherapeutic drugs paclitaxel and bortezomib. However targeting the extrinsic apoptosis pathway in vitro with a combination of bortezomib and agonist antibodies to the TRAIL death receptor DR5 was equally effective against both Nanog-GFP+ and Nanog-GFP- cell populations. To monitor Nanog expression in human breast cancer cells (SUM159), we used lentiviral vectors to introduce DNA constructs of the Nanog response element driving GFP and luciferase. About 0.5% of the SUM159 cells were GFP+ by FACS, and these cells also demonstrated some CSC characteristics such as enhanced colony formation in methylcellulose. Levels of GFP were increased in the SUM159 cells following cell culture under hypoxic conditions. These findings suggest that Nanog activity may be useful as surrogate marker of aggressive breast CSC subpopulations. Funded by NCI Contract HHSN261200800001E Citation Format: Thomas J. Sayers, Rachel de Kluyver, Marcella Kaddoura, Jim Stauffer, Poonam Tewary, Alan D. Brooks. Can Nanog activity identify aggressive breast cancer stem cell populations. [abstract]. In: Proceedings of the 105th Annual Meeting of the American Association for Cancer Research; 2014 Apr 5-9; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2014;74(19 Suppl):Abstract nr 3876. doi:10.1158/1538-7445.AM2014-3876
Perioperative confocal microscopy of the nail matrix in the management of<i>in situ</i>or minimally invasive subungual melanomas
Authors: S. Debarbieux, V. Hospod, L. Depaepe, B. Balme, N. Poulalhon, L. Thomas
Journal: British Journal of Dermatology (2012)

Although dermoscopy of the nail plate is helpful to discriminate between benign and malignant causes of nail pigmentations, there remain ambiguous cases in which a matricial biopsy is required. When a subungual melanoma is diagnosed histopathologically, a complementary surgical treatment is performed secondarily, the duration of postoperative disability being accordingly prolongated.The purpose of our study was to evaluate the feasibility of an intraoperative diagnosis by reflectance confocal microscopy (RCM).Our series included nine consecutive patients who underwent a matricial biopsy for an acquired melanonychia (one benign lentigo and eight melanomas). RCM examination was performed in vivo on the nail matrix after reclination of the nail plate, and/or ex vivo on the fresh tissue biopsy. RCM data were compared with histopathology.There was a good correlation between confocal and histopathological features. Seven melanoma cases were unequivocally diagnosed intraoperatively according to the confocal features, whereas the lentigo was correctly classified as a benign lesion according to RCM. The remaining lesion could not be unequivocally classified by RCM and corresponded histopathologically to an early melanoma that required immunostaining to be diagnosed.Intraoperative RCM examination of the nail matrix is an efficient diagnostic approach of melanonychia striata that permits an extemporaneous diagnosis of malignancy and therefore a one-step surgical treatment of in situ or minimally invasive melanoma, reducing dramatically the duration of postoperative disability.
Abstract 58: 5-HT promotes hepatocellular carcinoma by influencing β-catenin
Authors: Sarwat Fatima, Shi Xiaoki, Lin Zesie, Chen Guo, John W. Ho, Nikki P. Lee, Xiang Bian Zhao
Journal: Cancer Research (2015)

Abstract 5-hydroxytryptamine (5-HT), a neurotransmitter and vasoactive factor, has been reported to promote proliferation of serum-deprived human hepatocellular carcinoma cells (HCC) but the detailed intracellular mechanism is still unknown. As Wnt/β-catenin signaling is highly dysregulated in a majority of HCC, this study explored the regulation of Wnt/β-catenin signaling by 5-HT. 5-HT promoted proliferation of serum-deprived HuH-7 and HepG2 cells and also increased total β-catenin levels, and active β-catenin protein levels compared to just control cells under serum free medium without 5-HT. Furthermore, 5-HT increased β-catenin levels in the presence of cycloheximide, a protein synthesis inhibitor, suggesting increased β-catenin levels due to inhibition of β-catenin degradation. Quantitative real-time polymerase chain reaction (qPCR) showed increased β-catenin downstream target genes, Axin1, cyclin D1, dickoppf-1 (DKK1) and glutamine synthetase (GS), in serum-deprived HCC cell lines treated with 5-HT. We next studied the expression of various 5-HT were receptors (5-HT1D, 5-HT2A, 5-HT2B, 5-HT5 and 5-HT7) by qPCR in 33 pairs of HCC tumors and corresponding adjacent non-tumor tissues. Receptors 5-HT1D (21/33, 64%), 5-HT2B (12/33, 36%) and 5-HT7 (15/33, 45%) were overexpressed in HCC tumour tissues whereas receptor 5-HT5 was reduced (30/33, 91%) in HCC tumour tissues. Receptor 5-HT2A did not show any significant statistical difference between HCC tumour and corresponding non-tumour tissues. We further investigated whether antagonists of the 5-HT receptors attenuated the activity of 5-HT both in vitro and in vivo and we narrowed our study to 5-HT7 antagonist as the expression of 5-HT7 was found to be significantly associated to liver histology and venous infiltration. Antagonist of receptor 5-HT7, SB258719, attenuated growth of serum-deprived HCC cell lines and primary tumor tissues in the presence of 5-HT. Furthermore, SB258719 reduced tumor growth in a xenograft mouse model accompanied by reduced β-catenin and increased GSK-3β levels as observed by immunohistochemical analysis. Conclusion: This study provides evidence of Wnt/β-catenin signaling activation in 5-HT induced proliferation of serum-deprived HCC cells. The proliferation is inhibited by 5-HT7 antagonist, SB258719, which may represent a potential therapeutic target for hepatocarcinogenesis. Citation Format: Sarwat Fatima, Shi Xiaoki, Lin Zesie, Chen Guo, John W. Ho, Nikki P. Lee, Xiang Bian Zhao. 5-HT promotes hepatocellular carcinoma by influencing β-catenin. [abstract]. In: Proceedings of the 106th Annual Meeting of the American Association for Cancer Research; 2015 Apr 18-22; Philadelphia, PA. Philadelphia (PA): AACR; Cancer Res 2015;75(15 Suppl):Abstract nr 58. doi:10.1158/1538-7445.AM2015-58
Elder Abuse and Neglect a New Research Topic
Authors: Rebecca Voelker
Journal: JAMA (2002)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Abstract 2241: A Novel Measure of Diffuse Myocardial Fibrosis by Cardiac Magnetic Resonance
Authors: Saman Nazarian, David A Bluemke, Kathryn R Wagner, Brian S Caffo, Monda Shehata, David Edwards, Barbara Butcher, Hugh Calkins, Ronald D Berger, Henry R Halperin, Gordon F Tomaselli
Journal: Circulation (2008)

Despite the success of cardiac magnetic resonance (CMR) for identification of cohesive scar, its utility for quantification of diffuse myocardial fibrosis is unknown. We hypothesized that delayed enhancement intensity variance (DEIV) predicts conduction system disease due to diffuse myocardial fibrosis in myotonic muscular dystrophy (MMD). Thirty seven patients with MMD underwent CMR. The DEIV of the entire left ventricle was calculated by obtaining the variance of the mean intensity of each of 20 sectors per inversion recovery prepared gradient echo image plane (120 –200 sectors/patient, Medis software). Standard (ECG) and signal averaged electrocardiography (SAECG) with frank orthogonal leads at a sampling rate of 1 kHz/channel and enough QRS complexes to reduce the noise level to <1 microvolt were performed (Norav software). After correcting for potential confounders of DEIV and conduction disease (body mass index, age and left ventricular ejection fraction), DEIV was predictive of QRS duration on ECG ...
Not My Place?
Authors: Daniel A. Solomon
Journal: Annals of Internal Medicine (2015)

On Being a Doctor5 May 2015Not My Place?Daniel A. Solomon, MDDaniel A. Solomon, MDFrom Brigham and Women's Hospital, Boston, Massachusetts.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/M14-2139 Audio Reading - “Not My Place?” Audio. Michael A. LaCombe, MD, Annals Associate Editor, reads "Not My Place?," by D.A. Solomon. Your browser does not support the audio element. Audio player progress bar Step backward in current audio track Play current audio trackPause current audio track Step forward in current audio track Mute current audio trackUnmute current audio track 00:00/ SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail We all knew him as the “yellow man” who worked in the IT department. My co-residents and I shared some hushed words about him when he was working on the computer in the ICU or as he got off the elevator, his eyes as yellow as his skin. Do you think he's okay? Should we say something? He looks so sick! Do you know anything about him? No, but he sure is yellow. For several weeks he came to the hospital as an employee, working alongside doctors, nurses, and medical assistants, a part of our hospital community, fixing computers. It's ... Author, Article, and Disclosure InformationAffiliations: From Brigham and Women's Hospital, Boston, Massachusetts.Corresponding Author: Daniel A. Solomon, MD, Brigham and Women's Hospital, 75 Francis Street, PBB-A4, Boston, MA 02115. PreviousarticleNextarticle Advertisement Audio Reading - “Not My Place?” Audio. Michael A. LaCombe, MD, Annals Associate Editor, reads "Not My Place?," by D.A. Solomon. Your browser does not support the audio element. Audio player progress bar Step backward in current audio track Play current audio trackPause current audio track Step forward in current audio track Mute current audio trackUnmute current audio track 00:00/ FiguresReferencesRelatedDetails Metrics 5 May 2015Volume 162, Issue 9Page: 666-667KeywordsAlcoholsBilirubinComputersFearIntensive care unitsLiverSleepSpontaneous bacterial peritonitisSteroid therapyTachypnea ePublished: 5 May 2015 Issue Published: 5 May 2015 Copyright & PermissionsCopyright © 2015 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Dissinerjik Defekasyonda Biyogeribildirim, Sahte Geribildirim ve Standart Terapi Üzerine Randomize Kontrollü Araştırma
Authors: Satish S. C. Rao, Kara Seaton, Megan Miller, Kice Brown, Ingrid Nygaard, Phyllis Stumbo, Bridgette Zimmerman, ve Konrad Schulze
Journal: Clinical Gastroenterology and Hepatology (2007)
Abstract MP37: Effects of a Behavioral Intervention that Emphasizes Spices and Herbs on Adherence to Recommended Sodium Intake
Authors: Cheryl Anderson, Laura K Cobb, Edgar R Miller, Mark Woodward, Alex Chang, Morgana Mongraw-Chaffin, Lawrence J Appel
Journal: Circulation (2014)

Introduction: Adherence to the recommended dietary sodium intake is challenging given the ubiquity of sodium in the US food supply. We hypothesized that a multifactorial, behavioral intervention that emphasized spices and herbs would facilitate adherence to dietary sodium recommendations. Methods: SPICE was a two-phase study including adults, 18 years or older, for whom Dietary Guidelines for Americans recommends 1500 mg/d of sodium. In phase one, 55 individuals were fed a low sodium diet for 4 weeks to acclimatize them to eating according to dietary sodium recommendations. Participants were provided all food, snacks and calorie-containing drinks. In phase two, 40 participants from phase 1 were randomized to either a multifactorial behavioral intervention designed to reduce sodium intake (n=20) or a self-directed control group (n=20), for 20 weeks. The intervention included advice on replacing sodium with spices and herbs. The primary study outcome was 24-hour urinary sodium excretion. We used linear regression analyses to determine the effects of the intervention on urinary sodium excretion. Results: Participants were 65% female, 88% African American; 63% had hypertension, 18% had diabetes; mean(sd) age was 61(9.7) years, and BMI was 30(8.9) kg/m 2 . During phase one (controlled feeding), mean 24-hour urinary sodium excretion decreased (150 mmol/d to 72 mmol/d). At the end of the 20-week behavioral intervention, 24-hour urinary sodium excretion increased in both arms but was 42 mmol/d lower in the intervention group than in the control group, p=0.002 (Figure). These findings were robust to methods excluding incomplete urine collections (Mage equation: mean difference -47.4, p=0.001, Joosens equation: mean difference -34.6, p=0.04). Conclusions: A multi-factorial behavioral intervention that emphasizes spices and herbs facilitates adherence to the recommended dietary sodium intake.
Advanced Materials for Biomedical Application and Drug Delivery
Authors: Salam J.J. Titinchi, Mayank P. Singh, Hanna S. Abbo, Ivan R. Green
Journal: Advanced Healthcare Materials (2014)

This chapter contains sections titled: Introduction Anticancer Drug Entrapped Zeolite Structures as Drug Delivery Systems Mesoporous Silica Nanoparticles and Multifunctional Magnetic Nanoparticles in Biomedical Applications BioMOFs: Metal-Organic Frameworks for Biological and Medical Applications Conclusions
Angptl4 is upregulated under inflammatory conditions in the bone marrow of mice, expands myeloid progenitors, and accelerates reconstitution of platelets after myelosuppressive therapy
Authors: Anne Schumacher, Bernd Denecke, Till Braunschweig, Jasmin Stahlschmidt, Susanne Ziegler, Lars-Ove Brandenburg, Matthias B. Stope, Antons Martincuks, Michael Vogt, Dieter Görtz, Annalisa Camporeale, Valeria Poli, Gerhard Müller-Newen, Tim H. Brümmendorf, Patrick Ziegler
Journal: Journal of Hematology & Oncology (2015)

Upon inflammation, myeloid cell generation in the bone marrow (BM) is broadly enhanced by the action of induced cytokines which are produced locally and at multiple sites throughout the body. Using microarray studies, we found that Angptl4 is upregulated in the BM during systemic inflammation. Recombinant murine Angptl4 (rmAngptl4) stimulated the proliferation of myeloid colony-forming units (CFUs) in vitro. Upon repeated in vivo injections, rmAngptl4 increased BM progenitor cell frequency and this was paralleled by a relative increase in phenotypically defined granulocyte-macrophage progenitors (GMPs). Furthermore, in vivo treatment with rmAngptl4 resulted in elevated platelet counts in steady-state mice while allowing a significant acceleration of reconstitution of platelets after myelosuppressive therapy. The administration of rmAngptl4 increased the number of CD61+CD41low-expressing megakaryocytes (MK) in the BM of steady-state and in the spleen of transplanted mice. Furthermore, rmAngptl4 improved the in vitro differentiation of immature MKs from hematopoietic stem and progenitor cells. Mechanistically, using a signal transducer and activator of transcription 3 (STAT3) reporter knockin model, we show that rmAngptl4 induces de novo STAT3 expression in immature MK which could be important for the effective expansion of MKs after myelosuppressive therapy. Whereas the definitive role of Angptl4 in mediating the effects of lipopolysaccharide (LPS) on the BM has to be demonstrated by further studies involving multiple cytokine knockouts, our data suggest that Angptl4 plays a critical role during hematopoietic, especially megakaryopoietic, reconstitution following stem cell transplantation.
Decreased hypercapnic ventilatory response in long-term lung transplant recipients
Authors: Manuela Weidmann, Björn Kleibrink, Thomas Rabis, Gerhard Weinreich, Markus Kamler, Helmut Teschler, Urte Sommerwerck
Journal: European Respiratory Journal (2013)

Background: Bilateral lung transplantation is associated with complete denervation of the lung which might have an impact on hypercapnic ventilatory response (HCVR). Two previous small-scale studies on CO2 rebreathing showed no difference of HCVR between a mixed population of single and bilateral lung transplant recipients and healthy controls.

Objectives: HCVR was measured in bilateral lung transplant recipients and compared to healthy controls.

Methods: In an ongoing prospective study HCVR was tested according to Read’s method as described in 1968. Our study population consisted of 46 patients (21 women and 25 men body mass index (BMI) 25 ± 4 kg/m2, age 54 ± 11 years, time after transplantation 4.5 ± 2.5 years (range 10 month to 10 years)). In controls (14 women and 16 men) BMI was 25 ± 4 kg/m2 and age 38 ± 11 years.

Results: Lung transplant recipients: FEV1 predicted 76 ± 22, IVC predicted 91 ± 20, BGA (pO2 84 ± 13 mmHg, pCO2 36 ± 4 mmHg, pH 7,42 ± 0,03) at rest. Controls: FEV1 predicted 94 ± 13, IVC predicted 105 ± 14, BGA (pO2 90 ± 13 mmHg, pCO2 35 ± 3 mmHg, pH 7,43 ± 0,02). HCVR in lung transplant recipients was 1.44 ± 1.07 l/min/mmHg and 2.09 ± 1.08 l/min/mmHg in controls (p=0.001).

Conclusion: This study demonstrates a significant reduction in HCVR after bilateral lung transplantation between long-term lung transplant recipients and controls. The conflicting results to previous studies might be attributed to the incomplete denervation associated with single lung transplantation. Furthermore, our findings might explain the well-known reduced peak exercise capacity and oxygen consumption after bilateral lung transplantation.