tbuckley/cabot-search huggingface dataset:
Male genital lichen sclerosus and hepatitis C
Authors: T.N. Shim, C.B. Bunker
Journal: British Journal of Dermatology (2012)

Funding sources: Skin Treatment and Research Trust (START) and Sir John Fisher Foundation. Conflicts of interest: none declared. Madam, Male genital lichen sclerosus (MGLSc) is an acquired cutaneous disease of uncertain aetiology. It causes acute and chronic balanoposthitis and scarring that can result in significant sexual and urinary dysfunction and has been associated with squamous carcinoma of the penis. The aetiopathogenesis of MGLSc is unknown. Prior postulated pathogenic factors in GLSc include genetic and environmental influences, exposure to the irritant effects of urine and infections such as Borrelia and human papillomavirus. A relationship with hepatitis C virus (HCV) has been suggested by case reports of extragenital and genital LSc.1–3 We have therefore screened for HCV seropositivity in a cohort of patients with MGLSc. This work was approved by the local Research Ethics Committee (REC 09/H0607/58). We studied 61 men attending the Male Genital Dermatoses Clinics at Chelsea and Westminster (CWH) and University College Hospitals (UCH), London. All had clinical and histology findings consistent with the diagnosis of GLSc. None of the patients had extragenital LSc upon complete cutaneous examination. The age range was 22–72 years. Patients had blood samples taken for HCV antibody titre and conventional liver function tests (LFTs).
Abstract 165: Impact of Fever on Neurologic Outcome in Patients Undergoing Therapeutic Hypothermia Post Cardiac Arrest
Authors: Prachi U Thanawala, Natasha Fonseka, Gregary Marhefka
Journal: Circulation (2014)

Introduction:  Therapeutic hypothermia (TH) is thought to increase the rate of neurologic recovery after resuscitation from cardiac arrest. Recent evidence demonstrates that TH may be less significant than avoiding hyperthermia in preventing neurologic damage. The aim of this study is to review patients who underwent TH as a part of post cardiac arrest care and examine whether being febrile at a certain time point (i.e. 0-24hr, 24-48hr, 48-72hr) was associated with worse neurologic outcome.   Methods:  This is a retrospective analysis of 46 patients who underwent hypothermia protocol between 2008 and 2014 in the cardiac intensive care unit at a tertiary care center. Patients who were suitable for TH were cooled to maintain a target body temperature of 34° for 24 hours after return of spontaneous circulation (ROSC). Data collected through chart review included medical history, initial rhythm, disposition, temperature up to 72 hours post arrest, and cerebral performance category score (CPC) at discharge. Favorable CPC was defined as 1-2 whereas unfavorable was defined as 3-5. The primary outcome of this study was neurologic function quantified by the CPC score. A logistic regression model was used to determine the relationship between fever and CPC.   Results:  Within the cohort, 22 patients (48%) developed fever within 72 hours and 24 remained afebrile. There was a significant overall effect of fever timing (p=0.028), with the odds of favorable CPC significantly lower in all fever time points than in the reference category of no fever. Odds ratios between 0-24, 24-48, and 48-72 hours were not significant (p=0.671, 0.6721, and 0.954, respectively). Patients with fever at any time within 72 hours were significantly less likely to have a favorable CPC than those with no fever. People with no fever had 12.5 times the odds of a favorable CPC score than those with fever (OR =0.08, 95% CI (0.02, 0.37), p =0.001).   Conclusions:  Fever up to 72 hours post cardiac arrest is associated with poor neurologic outcomes. There was no significant difference in neurologic outcome between the different time groups, however patients with no fever had better neurologic outcome within each group.
236. Delivery of VEGF Using AAV Vectors Stimulates Skeletal Muscle Regeneration In Vivo
Authors: Luke M. Judge, Jeffrey S. Chamberlain
Journal: Molecular Therapy (2004)

Duchenne Muscular Dystrophy (DMD) is caused by absence of the protein dystrophin in skeletal muscle. Dystrophin completes a link between the extracellular matrix and the cytoskeleton by binding to β-dystroglycan and actin. It is also required for stable expression of the dystrophin-glycoprotein complex (DGC) that is thought to be involved in cell signaling. Thus, dystrophin may play both mechanical and signaling roles in muscle fibers. The mechanical defect in DMD is likely to be the initial cause of injury to the sarcolemma, which is then exacerbated by altered cellular signaling that results in increased apoptosis, inflammation, and fibrosis. Correction of the signaling defects could potentially reduce the severity and progression of muscle damage. In order to evaluate the relative importance of the signaling and mechanical functions of dystrophin we generated transgenic mice that express D116, the peripheral nerve-specific isoform of dystrophin, in skeletal muscle. Dp116 contains the complete WW, cysteine-rich and C-terminal domains of dystrophin, which are necessary for stabilization of the DGC and associated molecules important for cell signaling. However, Dp116 retains only two complete spectrin-like repeats from the central rod domain and does not contain any known actin-binding domains, thus it should not contribute to mechanical stabilization of the sarcolemma. Dp116 transgenic mice were backcrossed onto the mdx4cv strain, a model of DMD. Despite expression of Dp116 at the sarcolemma these mice have a dystrophic phenotype that appears to be at least as severe as that of mdx alone. This result implies that portions of the N-terminal and rod domains of dystrophin are absolutely required for prevention of the dystrophic pathology.
Abstract 17749: Magnetohydrodynamic Quantification of the Peripheral Perfusion Index in High-field MRI
Authors: T. Stan Gregory, Ehud J Schmidt, Shelley H Zhang, Jonathan R Murrow, Zion T Tse
Journal: Circulation (2014)

Background:  Peripheral Perfusion Index (PFI) measurements are typically used in the assessment of total body perfusion, commonly serving as indicators of tissue hypoxia and other potential risks [1]. PFI is typically recorded with pulse oximetry (PO), an indirect measurement. Magnetohydrodynamic Voltages (VMHD), caused by interaction of the MRI’s high-magnetic-field with blood-flow [2], are observed on ECG recordings performed inside MRI.   Objectives:  Develop a method to directly assess patient perfusion levels and PFI using VMHD observed on 12-lead ECGs in MRI.   Methods:  ECG data was collected in 5 healthy volunteers, using an MRI-conditional 12-lead ECG system. Measurements were performed while incrementally moving the bed into the bore of a 3T MRI. ECG sets were recorded at each positional step, and the real-ECG-signal subtracted from the total trace observed, thus extracting the VMHD contribution in each trace. A Vectorcardiogram (VCG) was then synthesized from the individual MHD signals using an inverse Dower transform [3], and integrated over the cardiac S-T segment, generating a metric proportional to the summed segmental perfusion (SSP) contributions. The SP at each step was solved for by using a linear decomposition matrix, weighting each term based on the magnetic field exposure. VMHD based PFI estimates were calculated as the ratio of aortic to extremity SP [4], and compared to PO- based measurements.   Results:  VMHD based PFI was calculated for all subjects, providing an error of    Conclusions:  VMHD-based PFI and perfusion measurements provide characteristic SP patterns and perfusion levels, at comparable accuracy to standard clinical methods.   Ref:  [1] Lima, Circulation, 2002. [2] Gupta, IEEE, 2008. [3] Dower, Clinical Cardiology, 1980. [4] Ridling, PediatrNurs, 2009.   Acknowledgements:  NIH U41-RR019703, NIH R03 EB013873-01A1, SBIR-1 R43 HL110427-01
Heinz Kohut's self psychology: an overview
Authors: Howard S. Baker, Margaret N. Baker
Journal: American Journal of Psychiatry (1987)

In the 16 years since its inception, self psychology has provided a comprehensive theory of psychopathology and treatment. It has articulated a new group of developmental needs and transferences: mirroring, idealizing, and alter ego. The failure of parental empathy to meet those needs during childhood results in the inability to develop intrapsychic structures that can reliably regulate self-esteem and calm the self, leaving the person overly dependent on those in the surround to provide those functions. Treatment requires careful understanding of the early failures and provides an environment in which the intrapsychic structures may belatedly and effectively develop.
Adolescents With Depression—Reply
Authors: John S. March
Journal: JAMA (2004)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
NSC101612 potently inhibits tumor cell growth and is a topoisomerase IIα catalytic inhibitor.
Authors: Xing Wu, Hong Liang, Brian B. Hasinoff
Journal: Cancer Research (2006)

Proc Amer Assoc Cancer Res, Volume 47, 2006

5533 

The fully substituted quinone NSC101612 (5,6-bis((2-hydroxyethyl)thio)-1H-benzimidazole-4,7-dione) was examined for its ability to inhibit cell growth and to inhibit human DNA topoisomerase IIα (topo II). NSC101612 significantly inhibited the catalytic activity of topo II with an IC50 value of 0.33 μM. NSC101612 also inhibited the growth of human erythroleukemic K562 and Chinese hamster ovary (CHO) cells with IC50 values of 28 μM and 48 μM, respectively. NSC101612 was also examined for its ability to stabilize a DNA-topo II covalent complex and act as a topo II poison by measuring its ability to cleave pBR322 DNA to produce linear DNA. It did not induce pBR322 DNA cleavage suggesting that it is not a topo II poison. The growth inhibitory effects of NSC101612 on K562 and K/VP.5 cells (an etoposide-resistant cell line containing one-fifth the topo II content of the parental K562 cells) were not significantly different. These results also suggest that NSC101612 did not act as a topo II poison. NSC101612 did not detectably increase levels of γH2AX protein in K562 cells, indicating that this compound did not act by damaging DNA, further confirming that this compound did not act as a topo II poison. Our spectrophotometric results showed that the quinone compound NSC101612 quickly reacted with the sulfhydryl compounds dithiothreitol (DTT), glutathione (GSH) and cysteine. DTT partially protected topo II from inhibition by NSC101612. These results suggest that this compound may inhibit topo II by reacting with critical thiol groups on topo II. The fact that DTT did not completely protect topo II from NSC101612 suggests that reaction with sulfhydryl groups on topo II may not be the only mechanism by which NSC101612 acts. In conclusion, our results suggest that NSC101612 may inhibit cell growth in part by inhibiting the catalytic activity of topo II. Support: CIHR and a Canada Research Chair in Drug Development.
Conduction and Infiltration Anesthesia.
Authors: Mendel Nevin
Journal: JAMA (1924)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Abstract 16495: A New Approach to Select Novel Potential Therapeutic Mirna Targets Effectively in the Cardiac Protection of Ischemia/Reperfusion (i/r) Injury
Authors: Yue Zhou, Qiying Chen, Karsheng Lew, Arthur M Richards, Peipei Wang
Journal: Circulation (2014)

Modulation of miRNAs is a potential therapeutic strategy in cardiac ischemic injury. Therefore a highly efficient approach to select potential therapeutic miRNA targets is needed. We have assessed selection of microRNAs based on differential dysregulation in ischemia-reperfusion (I/R) in the comparison of presence and absence of cardioprotective drugs. METHODS: Isolated rat hearts undergoing a I/R protocol were treated with 50 μM NaHS or 10 nM urocortin (UCN) in controlled experiments. Hearts were collected for miRNA array analysis (Exiqon). Up-regulated miRNAs were selected for high throughput functional screening. After transfection with 25 nmol of selected miRNA mimics, H9c2 and neonatal rat ventricular myocytes (NRVM) were subjected to 15 and 8 hours 0.2% O2 hypoxia / 2 hours re-oxygenation. Cell viability (WST) and injury (LDH release) were measured. RISK-loaded miRNAs from specific immunoprecipitation of protein Agonaute-2 were measured by qPCR. RESULTS: NaHS or UCN treatment doubled cardiac functio...
Sugar-Sweetened Beverages, Weight Gain, and Diabetes
Authors: Iain Murray, Sam Kazman
Journal: JAMA (2005)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
A memorable patient: Escape by water
Authors: J. Tye
Journal: BMJ (2001)

Our trekking party in north eastern Nepal had ascended to the magical Thyangboche Monastery at 3800m. We continued our descent and return journey through the village of Namche Bazaar (3400m) in high spirits, after completion of our mission. Suddenly our thoughts were interrupted when an anxious Sherpa raced up behind me. He told me that a doctor was needed and rushed me breathlessly back up the hill. I wrongly assumed that all of our party were ahead of me and wondered if I was being taken to sort out a medical problem in the village.

I was shown into one of the lodge rooms at Namche that we had left earlier. One member of …
Prevalence of permanent childhood hearing impairment
Authors: S. Amis
Journal: BMJ (2002)

Editor—We are the parents of a baby with profound sensorineural deafness, and the article by Fortnum et al rang many bells.1 The absence of universal screening of newborn infants seems a national scandal to us. If it had been in place we would not have waited nearly a year to discover that our baby has profound deafness. A year is a long time to lose when the early years are critical to the development of language and speech. The family friendly culture and seamless collaboration aspired to in the pilot protocols for universal screening seem a long way off. Lack of urgency from health professionals, a system that designs delay into it rather than managing delay out, and no real focus on customers or families are the dominant characteristics of the health service we have encountered.

Simple changes could make all the difference. Medical professionals are still dictating letters to secretaries and using the postal system to take a week or more to refer cases onwards when email could do it in minutes. A leading London hospital relied on a retired professional who comes in once a month to interpret computed tomography scans, automatically building in a six week delay. When we tried to track him down we discovered that he had been off sick for four weeks, yet this was not known to the departments that relied on him for results, and no alternative arrangements had been put in place.

When our daughter received her hearing aids, it would have been helpful to know that we could have battery covers that guard against the tiny batteries falling out and being accidentally swallowed. It would have been useful to be given a simple tubing tool and shown how to fit new tubing, vital after a baby has pulled the tubing out countless times. It should be obvious for the hospital to demand improvements from its earmould supplier when faced with turnaround times of two weeks that do not keep up with fast growing babies' ears.

These are just a few of the problems we have encountered. None of them is difficult to solve. The fact that they exist suggests that the family friendly hearing services, with a culture of service evaluation and feedback from parents that Fortnum et al hope for, cannot arrive a moment too soon.
Paroxysmal AF Catheter Ablation With a Contact Force Sensing Catheter
Authors: Andrea Natale, Vivek Y. Reddy, George Monir, David J. Wilber, Bruce D. Lindsay, H. Thomas McElderry, Charan Kantipudi, Moussa C. Mansour, Daniel P. Melby, Douglas L. Packer, Hiroshi Nakagawa, Baohui Zhang, Robert B. Stagg, Lee Ming Boo, Francis E. Marchlinski
Journal: Journal of the American College of Cardiology (2014)

Catheter ablation is important for treatment of paroxysmal atrial fibrillation (PAF). Limited animal and human studies suggest a correlation between electrode-tissue contact and radiofrequency lesion generation. The study sought to assess the safety and effectiveness of an irrigated, contact force (CF)-sensing catheter in the treatment of drug refractory symptomatic PAF. A prospective, multicenter, nonrandomized study was conducted. Enrollment criteria included: ≥3 symptomatic episodes of PAF within 6 months of enrollment and failure of ≥1 antiarrhythmic drug (Class I to IV). Ablation included pulmonary vein isolation with confirmed entrance block as procedural endpoint. A total of 172 patients were enrolled at 21 sites, where 161 patients had a study catheter inserted and 160 patients underwent radiofrequency application. Procedural-related serious adverse events occurring within 7 days of the procedure included tamponade (n = 4), pericarditis (n = 3), heart block (n = 1, prior to radiofrequency application), and vascular access complications (n = 4). By Kaplan-Meier analyses, 12-month freedom from atrial fibrillation/atrial flutter/atrial tachycardia recurrence was 72.5%. The average CF per procedure was 17.9 ± 9.4 g. When the CF employed was between investigator selected working ranges ≥80% of the time during therapy, outcomes were 4.25 times more likely to be successful (p = 0.0054; 95% confidence interval: 1.53 to 11.79). The SMART-AF trial demonstrated that this irrigated CF-sensing catheter is safe and effective for the treatment of drug refractory symptomatic PAF, with no unanticipated device-related adverse events. The increased percent of time within investigator-targeted CF ranges correlates with increased freedom from arrhythmia recurrence. Stable CF during radiofrequency application increases the likelihood of 12-month success. (THERMOCOOL® SMARTTOUCH® Catheter for Treatment of Symptomatic Paroxysmal Atrial Fibrillation; NCT01385202)
Abstract 16599: Impaired Right Ventricular Contractile Reserve During Exercise in Endurance Athletes With Right Ventricular Arrhythmias
Authors: Guido Claessen, Andre La Gerche, Jens-Uwe Voigt, Steven Dymarkowski, Luc Van Hees, Johan Van Cleemput, Piet Claus, Hein Heidbuchel
Journal: Circulation (2014)

Introduction: Ventricular arrhythmias in endurance athletes (EAs) frequently originate from a mildly dysfunctional right ventricle (RV). We evaluated whether RV dysfunction in EAs with ventricular arrhythmias of RV origin (EA-VAs) becomes more apparent during exercise than at rest. Methods: Ten healthy EAs, 7 healthy non-athletes (NAs) and 17 EA-VAs (8 with ICD) first underwent cardiopulmonary exercise testing to determine maximal power (Pmax). Then, exercise echocardiography was performed at 25%, 50% and 66% of Pmax to measure the RV end-systolic pressure-area ratio (ESPAR), a surrogate of RV contractility, which was calculated as systolic pulmonary artery pressure/RV end-systolic area. Finally, all subjects without ICD underwent cardiac MRI during supine bicycle exercise at similar workloads with simultaneous invasive pulmonary artery pressure measurement to determine the RV end-systolic pressure-volume ratio (SP/ESV). Results: At rest, RV ESPAR was similar in EA-VAs relative to NAs (P=0.1), although slightly lower than in NAs (P=0.02). During exercise, EA-VAs had an impaired increase in RV ESPAR compared to both EAs and NAs (interaction P&lt;0.0001; Figure 1A). Also the slopes of RV ESPAR to absolute workload (in Watts) were lower in EA-VAs than in EAs and NAs (P&lt;0.0001) and correlated highly with the slopes of RV SP/ESV to workload obtained by MRI and invasive pressure measures (R=0.75; P&lt;0.0001). Figure 1B shows that resting and peak exercise RV ESPAR cutoffs of 1.4 and 3.9 mmHg/cm 2 had a sensitivity of 77% and 79% and specificity of 80% and 100%, respectively, to identify EA-VAs. Conclusion: EA-VAs have impaired RV contractility which is evident during exercise but hardly at rest. This strengthens the association between RV arrhythmias and functional impairment. Our data suggest that exercise echocardiography is sufficiently accurate to determine RV contractile reserve in a non-invasive manner and may assist in risk stratification of RV remodeling in EAs.
Late onset of renal and hepatic cysts in Pkd1-targeted heterozygotes
Authors: Weining Lu, Xiaohong Fan, Nuria Basora, Hermik Babakhanlou, Terry Law, Nader Rifai, Peter C. Harris, Antonio R. Perez-Atayde, Helmut G. Rennke, Jing Zhou
Journal: Nature Genetics (1999)