tbuckley/cabot-search huggingface dataset:
Effect of Budesonide and Formoterol Administered Via One Pressurized Metered-dose Inhaler on Lung Function in Adults and Adolescents With Moderate to Severe Persistent Asthma
Authors: M.J. Noonan, L.J. Rosenwasser, P. Martin, C.D. O'Brien, L. O'Dowd
Journal: Journal of Allergy and Clinical Immunology (2007)
Rapid Clot-Dissolving Drugs Promising for Stroke
Authors: Andrew A. Skolnick
Journal: JAMA (1993)

RAPID and aggressive treatment of ischemic strokes with clot-dissolving drugs may prevent severe disability or death in many patients, say presenters at the recent 78th Scientific Assembly and Annual Meeting of the Radiological Society of North America (RSNA), in Chicago, Ill. The researchers reported preliminary results of clinical trials involving a small number of patients in the United States and France. Despite the small number, the rapid and dramatic recovery of critically ill stroke patients has prompted the researchers to predict that the care of ischemic stroke might be revolutionized by adopting an approach that is similar to the way heart attacks are now treated. "Strokes do not have to be catastrophic, life-shattering events," says Larry-Stuart Deutsch, MD, chief of cardiovascular and interventional radiology at the University of California, Irvine. Preliminary results suggest that if treatment is instituted promptly, many strokes caused by blood clots may be treated effectively with
Exanthem Due to Contact Allergen (Benzoin) Absorbed Through Skin
Authors: David A. Spott
Journal: JAMA (1970)

A student developed acute eczematous contact dermatitis in response to the application of tincture of benzoin to the skin under a cast. This was followed within 48 hours by the appearance of generalized noneczematous exanthem. Analysis led to the conclusion that absorption of benzoin through the skin was responsible for both the contact dermatitis and the exanthem. Patch tests demonstrated an eczematous reaction to benzoin, with cross sensitivity extending to the gums of myrrh, locust, galbanum, gamboge, and olibanum.
The Grands Boulevards
Authors: M. Therese Southgate
Journal: JAMA (2006)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Endocrine Oncology
Authors: V. Spataro
Journal: Annals of Oncology (2002)

This book contains twenty chapters addressing many topics in the field of endocrine oncology, almost exclusively from the vantage point of molecular pathogenesis, genetics and pharmacology, with little coverage of the clinical aspects. The main focus of the book is the endocrinology of cancers of the breast, prostate, endometrium and ovary, whereas there is very little information on cancers of endocrine tissues. As usual in this type of book, the depth in which the topics are covered is very heterogeneous and varies according to how hot the field is as a research area, rather than its current clinical importance. Along these lines, the reader will find plenty of information on epidermal growth factor-related peptides in endocrine neoplasia and relatively little on important topics, such as selective estrogen-receptor modulators or aromatase inhibition. All the contributions are of excellent scientific quality and the authors are recognized experts in their fields. Most chapters provide good figures and tables and an extensive reference section. The chapter on tamoxifen and other antiestrogens in the prevention and treatment of breast cancer is one of the more clinically oriented, and is very clearly written and prac-tical. In contrast, the single chapter on BRCA genes is the weakest of the book and does not add anything to the general value of the volume. This book will be useful as a reference book, mainly to those who have a strong research interest in the field of breast and/or prostate cancer and those who need an update on molecular advances in a particular field of endocrine oncology. Most of the information contained in this book is of little use to the clinical oncologist.
Gram-negative Bacteremia in Dogs.
Authors: Burton A. Waisbren
Journal: Annals of Internal Medicine (1965)

s1 May 1965Gram-negative Bacteremia in Dogs.Burton A. Waisbren, M.D., F.A.C.P., James W. Hainer, B.S., Irving Lutsky, V.M.D., Theofilos Tsaqaris, M.D.Burton A. Waisbren, M.D., F.A.C.P.Search for more papers by this author, James W. Hainer, B.S.Search for more papers by this author, Irving Lutsky, V.M.D.Search for more papers by this author, Theofilos Tsaqaris, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-62-5-1089_2 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThis investigation was undertaken to see if the injection of living gram-negative bacilli into dogs would give a picture more similar to gram-negative shock in humans than that seen after the injection of endotoxin into dogs. The first dog injected intravenously with livingEscherichia coliproved to be resistant not only to large numbers of living organisms but also to a concentration of 10 mg/kg of endotoxin (that is, five times the lethal dose). Forty-eight of the next 50 dogs injected with livingE. colidied in spite of the therapy of chloramphenicol, hydrocortisone, and the combination of chloramphenicol and... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Milwaukee, Wisconsin PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byExocrine function and histologic changes of the pancreas in chronic hepatic diseases 1 May 1965Volume 62, Issue 5Page: 1089-1089KeywordsAttentionBacteremiaChloramphenicolEndotoxinsEscherichia coliLethal doseShock ePublished: 1 December 2008 Issue Published: 1 May 1965 PDF downloadLoading ...
INTERNISTS AS FAMILY PHYSICIANS
Authors: EDMUND B. FLINK
Journal: Annals of Internal Medicine (1967)

Letters and Comments1 July 1967INTERNISTS AS FAMILY PHYSICIANSEDMUND B. FLINK, M.D.EDMUND B. FLINK, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-67-1-219 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the Editor: I am writing to commend you on the publishing of the editorial by William W. Engstrom, M.D., in the March 1967 ANNALS OF INTERNAL MEDICINE.In a few pages, Dr. Engstrom in characteristic thoroughness has analyzed the symptoms, gathered data, and come up with a diagnosis. Every physician should read this editorial. It is important to note that he acknowledges the fact that everything is not entirely perfect in our training methods and in our method of delivering medical care. He comes up with some very practical and attainable suggestions about improvement of our training. In his...Reference1. : Medical Care for the American People. The University of Chicago Press, Chicago, 1932. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: EDMUND B. FLINK, M.D.Affiliations: PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 July 1967Volume 67, Issue 1Page: 219-221 ePublished: 1 December 2008 Issue Published: 1 July 1967 PDF downloadLoading ...
Pl <sup>A2</sup> Polymorphism of β <sub>3</sub> Integrins Is Associated With Enhanced Thrombin Generation and Impaired Antithrombotic Action of Aspirin at the Site of Microvascular Injury
Authors: Anetta Undas, Kathleen Brummel, Jacek Musial, Kenneth G. Mann, Andrew Szczeklik
Journal: Circulation (2001)

Background Mechanisms by which the Pl A2 (Leu33Pro) polymorphism of β 3 integrins could lead to an increased risk for coronary events are unclear. This study was designed to examine the effect of this polymorphism on blood coagulation. Methods and Results In normal subjects (12 with Pl A1A1 , 9 with Pl A1A2 , and 3 with Pl A2A2 ), we evaluated the activation of prothrombin, factor V, and factor XIII and fibrinogen removal by quantitative immunoblotting; thrombin-antithrombin III complex generation using ELISA; and levels of fibrinopeptide A and B by high-performance liquid chromatography in blood collected every 30 seconds at sites of standardized microvascular injury before and after 7 days of aspirin ingestion (75 mg/d). Compared with the Pl A1A1 subjects, the Pl A2 carriers exhibited higher maximum rates of thrombin B-chain generation (by 31.6%; P =0.005), thrombin-antithrombin III complex generation (by 30.7%; P =0.003), fibrinogen consumption (by 31.3%; P =0.002), prothrombin consumption (by 26.1%; P =0.011), and activation of factor V (by 14.1%; P =0.033) and factor XIII (by 27.0%; P =0.012). In the Pl A1A1 homozygotes, aspirin ingestion resulted in reductions in the velocity of thrombin B-chain formation (by 32.1%; P =0.007), prothrombin consumption (by 30.4%; P =0.018), factor Va generation (by 28.9%; P =0.014), fibrinogen removal (by 41.2%; P =0.001), and factor XIII activation (by 22.6%; P =0.026). In the Pl A2 carriers, aspirin did not alter the velocity of all these processes. After aspirin ingestion, fibrinopeptide A and B concentrations in the last 30-second interval were significantly reduced, but only in the Pl A1A1 subjects. Conclusions The presence of the Pl A2 allele is associated with enhanced thrombin formation and an impaired antithrombotic action of aspirin, which might favor coronary thrombosis in the Pl A2 carriers.
Tolerability of Concomitant Administration of Mometasone Furoate and Oxymetazoline Nasal Sprays Administered Once Daily vs Oxymetazoline Twice Daily, Mometasone Furoate Once Daily, and Placebo in the Treatment of Subjects With Seasonal Allergic Rhinitis
Authors: A.S. Nayak, B. Prenner, D. Gates, T. Shekar, A. Teper
Journal: Journal of Allergy and Clinical Immunology (2010)
Antiprostaglandins for Primary Dysmenorrhea
Authors: Penny W. Budoff
Journal: JAMA (1981)

<h3>To the Editor.—</h3> Primary dysmenorrhea is defined as painful menstruation characterized by the absence of clinical pelvic abnormality. It usually has its onset during the teenage years when menses become ovulatory. Primary dysmenorrhea is a major cause of lost workdays and school days around the world. Recent research has shown that the problem can be alleviated in most women by the administration of antiprostaglandin medications. Studies indicate that 80% to 85% of women respond to antiprostaglandin drug therapy. Women who fail to respond often are considered as not having a prostaglandin basis to their dysmenorrhea, or as having a psychological overlay. In my practice, however, I have found that, in these women, by switching to a second, third, or even fourth drug, more than 95% will respond. The basis for improvement with one antiprostaglandin medication, but not another, probably lies in individual chemical idiosyncracy. Another related phenomenon is the development
Abstract 1756: Intravital imaging of cancer cell cycle in the bone marrow.
Authors: Shuya Yano, Shinji Miwa, Yasunori Tome, Fuminari Uehara, Michelle Digman, Enrico Gratton, Robert M. Hoffman
Journal: Cancer Research (2013)

Abstract The cell cycle of cancer cells in the bone marrow was imaged using a fluorescence ubiquitination cell cycle indicator (FUCCI). With FUCCI, quiescent cancer cells express mKusabira-Orange fluorescent protein (red) and proliferating cells express mAzami-Green fluorescent protein (green). FUCCI-expressing cancer cells were injected into the bone marrow of tibia of mice. At the early stage after injection (7 days), approximately 90% of the cells were in G0/G1. In contrast, at late stage after injection (28 days more), in the endosteal lesion, approximately 80% of the cancer cells were in S/G2/M phases and in the central zone, approximately 75% of cancer cells were in G0/G1. Thus, cancer-cell location and time in the bone marrow determines cell cycle position and possibly dormancy. Thus, quiescent (dormant) cancer cells in the bone marrow need to be targeted as well as proliferating cancer cells, which is a significant current challenge. Citation Format: Shuya Yano, Shinji Miwa, Yasunori Tome, Fuminari Uehara, Michelle Digman, Enrico Gratton, Robert M. Hoffman. Intravital imaging of cancer cell cycle in the bone marrow. [abstract]. In: Proceedings of the 104th Annual Meeting of the American Association for Cancer Research; 2013 Apr 6-10; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2013;73(8 Suppl):Abstract nr 1756. doi:10.1158/1538-7445.AM2013-1756
Hospital admissions among students
Authors: T. C. Dann
Journal: BMJ (1967)

MEDICALIShURNALvolved the surrounding muscles, causing con- siderable damage.In each case an unfortunate milkman had slipped on a wet and slippery pavement or step and fallen heavily on a glass bottle, which had shattered and caused the injury.Altogether a total of about three hours was taken for treatment of these cases, the work involving up to three doctors at any one time, with a difficult exploration and nerve suture.Our casualty department sees and treats between 80 and 120 new attendances daily from a large catchment area, including dock- yards and a motorway.There is one duty casualty officer, with orthopaedic and surgical firms on call, and a second casualty officer seeing reattendances for a few hours in the morning only, and such lacerations impose a severe strain, involving delay in treatment for many patients.Prevention is always better than a cure, which often is incomplete in these cases.Little can be done about our English weather and wet slippery pavements, but surely in this age of plastics much time and expense would be saved to busy casualty departments and the public if milk, distributors and brewers would supply their products in polyethylene bottles.Is there some objection to this or do these firms not realize the potential danger of their containers ?-I am, etc.,
Out of Practice: Fighting for Primary Care Medicine in America
Authors: William Ventres
Journal: JAMA (2012)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Points: Epidemic of prosthetic valve endocarditis
Authors: A W Fowler
Journal: BMJ (1985)

relatively little time available to talk to their inpatients because they are responsible for patients in several hospitals and are also concerned in work in the community, which may be particularly time consuming.Psychiatric firms usually have one junior trainee per site (or part ofone), and there are no housemen, so on call duties are shared by SHOs/registrars, whose posts usually coalesce to form training programmes involving enough firms and units to allow varied experience in a rotating scheme.Cuts in the numbers of junior psychiatric training posts are being proposed in many places and in some cases are draconian.If these numbers are reduced in this way without either a significant increase in consultant numbers or a commensurate increase in non-trainee junior posts then the standard of service may decline unacceptably in many places.Some regions err in supposing that manpower needs and use in psychiatry are essentially the same as in medical and surgical specialties.
Puerperal Erythema Nodosum after Liver Extract Injections
Authors: F. D. C. Ford
Journal: BMJ (1960)

MEDICBRmSJURNALprevious history of illness are suggestive of the presence of histoplasmosis infection, particularly in the riverine areas.Though no definite conclusions can be drawn about the extent of the incidence of histoplasmosis in Dclhi and in other parts of the country from the present study, it undoubtedly emphasizes the uirgent need for a more comprehensive survey which will provide further information about the epidemiology of the disease in this country. SummaryA pilot histoplasmin survey was carried out in the Delhi area.Skin tests were performed on 747 people from different places representing rural, urban, and riverine areas of Delhi.12.3% positive reactors were found in the riverine area, 2.9 % in the rural area, and 4.9% in the urban area.Cultural and serological examinations of histoplasmin- positive reactors were all negative.Our thanks are due to Dr. Hans F. Smetana, who suggested the pilot study, to Dr. Mi. L. Passi
Preventive Medicine Extends to Injuries, Too
Authors: Paul Cotton
Journal: JAMA (1990)

INJURIES are not accidents, says Vernon Houk, MD, an assistant surgeon general in the Public Health Service and director of the CDC's Center for Environmental Health and Injury Control in Atlanta, Ga. Houk fines staff members 25 cents any time they utter the word "accident." "He rightly argues that the word implies something is unpredictable, that there's no pattern to it," says Mark Rosenberg, MD, director of the center's Division of Injury Epidemiology and Control. He vividly recalls having to dig for change in front of one of the top officials of the Department of Health and Human Services—"the assistant secretary for health. I used That Word, and he [Houk] stopped me dead in my tracks and asked for his quarter." Rosenberg paid up because he agrees that the biggest barrier to reducing the incidence of injury is the "notion that things are just accidents you can't do anything about."
Long-Term Therapy for Reflux Esophagitis
Authors: G.N.J. Tytgat
Journal: New England Journal of Medicine (1995)

In gastroesophageal reflux disease, a failure of the barrier function between the stomach and the esophagus allows an excessive reflux of gastric or duodenogastric contents. Reflux disease is often chronic and tends to relapse. Although the disease often does not progress, it does in some patients. In up to 20 percent of patients, complications ultimately develop, such as stricture or columnar metaplasia. Relapse often occurs because underlying motor abnormalities are not improved after a course of medical therapy. Current therapy is based on reducing the amount of the refluxed material and its potential to cause injury by suppressing acid secretion . . .
132 Assessment of bile produced during normothermic extreacorporeal perfusion by heart-beating and non-heart-beating-donor livers: Proton magnetic resonance spectroscopic study
Authors: M.M. Habib, T.S. Hafez, H.G. Parkes, A.M. Seifalian, B.J. Fuller, B.R. Davidson
Journal: Journal of Hepatology (2004)
Dissecting childhood asthma with nasal transcriptomics distinguishes subphenotypes of disease
Authors: Alex Poole, Cydney Urbanek, Celeste Eng, Jeoffrey Schageman, Sean Jacobson, Brian P. O'Connor, Joshua M. Galanter, Christopher R. Gignoux, Lindsey A. Roth, Rajesh Kumar, Sharon Lutz, Andrew H. Liu, Tasha E. Fingerlin, Robert A. Setterquist, Esteban G. Burchard, Jose Rodriguez-Santana, Max A. Seibold
Journal: Journal of Allergy and Clinical Immunology (2014)
22 ELECTROSTATIC MODIFICATIONS OF THE HLA-DR P9 PEPTIDE-BINDING POCKET AND SUSCEPTIBILITY TO PRIMARY SCLEROSING CHOLANGITIS
Authors: J.R. Hov, V. Kosmoliaptsis, J.A. Traherne, M. Olsson, K.M. Boberg, A. Bergquist, E. Schrumpf, J.A. Bradley, C.J. Taylor, B.A. Lie, J. Trowsdale, T.H. Karlsen
Journal: Journal of Hepatology (2011)
Tolerability of Rofecoxib versus Naproxen
Authors: Lonnie B. Hanauer
Journal: Annals of Internal Medicine (2004)

Letters15 June 2004Tolerability of Rofecoxib versus NaproxenLonnie B. Hanauer, MDLonnie B. Hanauer, MDFrom Millburn, NJ 07041.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-140-12-200406150-00020 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:The article comparing rofecoxib with naproxen (1) appears to have been mistakenly published in the editorial pages of Annals rather than the advertising section, where it seems to belong. The article was supported by Merck & Co. and written by employees or consultants of Merck. In addition, requests for reprints go to Merck. All of this might be reasonable if the article included any new, fair, or reasonable information.Selective cyclooxygenase-2 inhibitors (coxibs) as a subset of nonsteroidal anti-inflammatory drugs (NSAIDs) have been available for more than 5 years and are generally accepted as having less gastrointestinal ...Reference1. Lisse JR, Perlman M, Johansson G, Shoemaker JR, Schechtman J, Skalky CS, et al . Gastrointestinal tolerability and effectiveness of rofecoxib versus naproxen in the treatment of osteoarthritis: a randomized, controlled trial. Ann Intern Med. 2003;139:539-46. [PMID: 14530224] LinkGoogle Scholar2. Spiegel BM, Targownik L, Dulai GS, Gralnek IM. The cost-effectiveness of cyclooxygenase-2 selective inhibitors in the management of chronic arthritis. Ann Intern Med. 2003;138:795-806. [PMID: 12755551] LinkGoogle Scholar Author, Article, and Disclosure InformationAffiliations: From Millburn, NJ 07041. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoThe Cost-Effectiveness of Cyclooxygenase-2 Selective Inhibitors in the Management of Chronic Arthritis Brennan M.R. Spiegel , Laura Targownik , Gareth S. Dulai , and Ian M. Gralnek Gastrointestinal Tolerability and Effectiveness of Rofecoxib versus Naproxen in the Treatment of Osteoarthritis Jeffrey R. Lisse , Monica Perlman , Gunnar Johansson , James R. Shoemaker , Joy Schechtman , Carol S. Skalky , Mary E. Dixon , Adam B. Polis , Arthur J. Mollen , Gregory P. Geba , and Tolerability of Rofecoxib versus Naproxen John M. Rusche Tolerability of Rofecoxib versus Naproxen M. L. Jenkinson Tolerability of Rofecoxib versus Naproxen Jeffrey R. Lisse , Monica Perlman , Adam B. Polis , and Gregory P. Geba Metrics 15 June 2004Volume 140, Issue 12Page: 1059KeywordsAdverse reactionsDrugsElderlyMedical risk factorsNSAIDsOsteoarthritisToxicity ePublished: 15 June 2004 Issue Published: 15 June 2004 Copyright & PermissionsCopyright © 2004 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...