tbuckley/cabot-search huggingface dataset:
Dissociation of Antiviral and Antitumor Immunity in Resistance to Marek's Disease
Authors: P. C. Powell, J. G. Rowell
Journal: JNCI Journal of the National Cancer Institute (1977)

Immunization of chickens either with gluteral-dehyde-inactivated chicken kidney cells infected with Marek's disease (MD) virus or with glutaraldehyde-inactivated cells of MD lymphoma-derived continuous lymphoblastoid cell lines protected against MD. The former type of immunity was associated with an immunologic suppression of virus replication and virus antigen production after challenge with virulent virus, but lymphocytes specifically cytotoxic to cells bearing MD tumor antigens were not detected. In the latter type of immunity, virus multiplication was not affected; some evidence of the stimulation of cell-mediated antitumor immunity was found. The results supported the view that immunity to MD may be directed against either virus-specific or tumor-specific antigens and that in natural resistance to MD both mechanisms may be operative.
Risk factors, etiology and prognosis of adult patients with hospital -acquired pneumonia in Shanghai
Authors: Ning Li, Qijian Cheng
Journal: European Respiratory Journal (2012)

Objective To investigate clinical features, risk factors, drug resistance, and clinical outcomes of hospital-acquired pneumonia (HAP) in Shanghai. Methods From November 2007 to December 2009, HAP was observed and prospectively studied in Shanghai seven large general hospitals. Clinical data and etiology of pneumonia were recorded. Blood and sputum cultures, identification of bacteria in specimen and drug sensitivity test were performed. Results We included 204 patients (mean age 68.07 ± 16.61 years [± SD], 58.3% more than 70 years old) mainly from surgical wards, surgical ICU, medical wards, and medical ICU. Patients were complicated with cerebral vascular disease (19.61%), diabetes mellitus (14.22%), or abdominal surgery (11.76%). Ventilator-associated pneumonia occurred in 20.6% of the cases. Total mortality was 15.69%. Increased heart rate, decreased arterial PH, hypoxia, high glucose, increased plasma creatinine and vasopressor use were associated with the poor outcome in patients with HAP. In all bacterial isolates from HAP, 64.90% were gram-negative bacilli bacteria, including Acinetobacter baumannii , Pseudomonas aeruginosa , Klebsiella pneumoniae , and Escherichia coli . 26.5% of the isolates were Staphylococcus aureus and the rate of MRSA was 65.4%. Conclusion The elderly, cerebrovascular diseases, and diabetes are risk factors of HAP and septic shock is the most important complication associated with poor prognosis of HAP. In this setting, Acinetobacter baumannii , Pseudomonas aeruginosa , Klebsiella pneumoniae , Escherichia coli , and Staphylococcus aureus (MRSA 60%) should be considered as the common etiologic pathogens of HAP.
A randomized, double-blind, placebo-controlled, phase III trial of erlotinib with or without a c-Met inhibitor tivantinib (ARQ 197) in Asian patients with previously treated stage IIIB/IV nonsquamous nonsmall-cell lung cancer harboring wild-type epidermal growth factor receptor (ATTENTION study)
Authors: H. Yoshioka, K. Azuma, N. Yamamoto, T. Takahashi, M. Nishio, N. Katakami, M.J. Ahn, T. Hirashima, M. Maemondo, S.W. Kim, M. Kurosaki, S. Akinaga, K. Park, C.M. Tsai, T. Tamura, T. Mitsudomi, K. Nakagawa
Journal: Annals of Oncology (2015)
Abstract 9637: Outcomes in Pediatric Cardiac Arrest with Pulseless Ventricular Tachycardia or Ventricular Fibrillation with use of Amiodarone versus Lidocaine
Authors: Santiago O Valdes, Aaron J Donoghue, Derek B Hoyme, Marc D Berg, Robert A Berg, Ricardo A Samson
Journal: Circulation (2012)

BACKGROUND: Current PALS guidelines recommend amiodarone for cardiac arrest associated with refractory pulseless ventricular tachycardia (pVT) and ventricular fibrillation (VF), based on a single pediatric study and extrapolation from adult data. We sought to compare outcomes of refractory pVT/VF arrest treated with amiodarone or lidocaine. METHODS: Retrospective cohort study from the Get With the Guidelines-Resuscitation database for in-patient cardiac arrest. Patients &lt; 18 years old with pVT/VF cardiac arrest treated with amiodarone, lidocaine or both were included. Patients receiving amiodarone or lidocaine prior to arrest were excluded. Univariate analysis compared Utstein outcomes (ROSC, 24 hour survival, survival to discharge) between those receiving amiodarone, lidocaine or both (chi square analysis). Multivariate analysis was done to estimate the association between amiodarone and lidocaine and survival outcomes while controlling for potential confounders among patient, event and treatment characteristics. RESULTS: A total of 358 patients met all inclusion criteria. Utstein outcomes are summarized below. Univariate analysis demonstrated significant differences between groups in ROSC and 24 hour survival; survival to discharge did not differ significantly. Multivariate analysis showed improved 24 hour survival with lidocaine compared to amiodarone (adjusted odds ratio 1.78, 95% CI 1.12 - 2.84) while controlling for the above confounders. Neither amiodarone or lidocaine was significantly associated with ROSC or survival to discharge. CONCLUSIONS: For children with in-hospital refractory pVT/VF, lidocaine use without amiodarone was independently associated with improved 24 hour survival. Amiodarone alone or in combination with lidocaine was not associated with superior rates of ROSC, survival at 24 hours, or survival to discharge. Lidocaine should be considered in the treatment of pediatric cardiac arrest with pVT/VF.
Abstract 21191: Disturbed Flow-Mediated Reactive Oxygen Species Production and Subsequent Protein Kinase C{zeta} Activation Plays a Key Role in Endothelial Apoptosis via PIASy (SUMO E3 ligase)-Mediated p53-SUMOylation and p53 Protein Stability
Authors: Kyungsun Heo, Hakjoo Lee, Patrizia Nigro, Nhat-Tu Le, Eugene Chang, Carolyn McClain, Bradford C Berk, Keigi Fujiwara, Chang-Hoon Woo, Jun-ichi Abe
Journal: Circulation (2010)

Atherosclerosis formation is readily observed in certain areas of the arterial tree such as branch points, which experience disturbed flow (d-flow). A positive correlation between protein kinase C ...
BRAF codons 594 and 596 mutations identify a new molecular subtype of metastatic colorectal cancer at favorable prognosis
Authors: C Cremolini, M Di Bartolomeo, A Amatu, C Antoniotti, R Moretto, R Berenato, F Perrone, E Tamborini, G Aprile, S Lonardi, A Sartore-Bianchi, G Fontanini, M Milione, C Lauricella, S Siena, A Falcone, F de Braud, F Loupakis, F Pietrantonio
Journal: Annals of Oncology (2015)
Review: Type 2 diabetes screening does not reduce mortality but treating dysglycemia delays onset of diabetes
Authors: Michael Tanner
Journal: Annals of Internal Medicine (2015)

ACP Journal Club15 September 2015Review: Type 2 diabetes screening does not reduce mortality but treating dysglycemia delays onset of diabetesMichael Tanner, MDMichael Tanner, MDNew York University School of Medicine, New York, New York, USA (M.T.)Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/ACPJC-2015-163-6-002 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail Source CitationSelph S, Dana T, Blazina I, et al. Screening for type 2 diabetes mellitus: a systematic review for the U.S. Preventive Services Task Force. Ann Intern Med. 2015;162:765-76. https://pubmed.ncbi.nlm.nih.gov/25867111Clinical Impact RatingsGIM/FP/GP: Endocrinology: References1. Centers for Disease Control and Prevention. National diabetes statistics report: Estimates of diabetes and its burden in the United States, 2014. Atlanta, GA: US Department of Health and Human Services; 2014. Google Scholar2. American Diabetes Association. Standards of medical care in diabetes—2015. Diabetes Care. 2015;38(Suppl 1):S1-S93. Google Scholar3. James PA, Oparil S, Carter BL, et al. 2014 evidence-based guideline for the management of high blood pressure in adults: report from the panel members appointed to the Eighth Joint National Committee (JNC 8). JAMA. 2014;311:507-20. [PMID: 24352797] Google Scholar Author, Article, and Disclosure InformationAffiliations: New York University School of Medicine, New York, New York, USA (M.T.)This article was published at Annals.org on 1 September 2015. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byWho is getting screened for diabetes according to body mass index and waist circumference categories in Peru? a pooled analysis of national surveys between 2015 and 2019 15 September 2015Volume 163, Issue 6Page: JC2KeywordsBlood pressureDrugsGlucoseGlucose intoleranceHazard ratioMortalitySystematic reviewsType 2 diabetesVisual impairments ePublished: 15 September 2015 Issue Published: 15 September 2015 Copyright & PermissionsCopyright © 2015 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Risk of Nonmelanoma Skin Cancer Associated With the Use of Immunosuppressant and Biologic Agents in Patients With a History of Autoimmune Disease and Nonmelanoma Skin Cancer
Authors: Frank I. Scott, Ronac Mamtani, Colleen M. Brensinger, Kevin Haynes, Zelma C. Chiesa-Fuxench, Jie Zhang, Lang Chen, Fenglong Xie, Huifeng Yun, Mark T. Osterman, Timothy Beukelman, David J. Margolis, Jeffrey R. Curtis, James D. Lewis
Journal: JAMA Dermatology (2015)

Immune dysfunction underlies the pathogenesis of rheumatoid arthritis (RA) and inflammatory bowel disease (IBD). Immunosuppressive therapy is the standard of care for these diseases. Both immune dysfunction and therapy-related immunosuppression can inhibit cancer-related immune surveillance in this population. Drug-induced immunosuppression is a risk factor for nonmelanoma skin cancer (NMSC), particularly squamous cell tumors. For patients with a history of NMSC, data are limited on the effect of these drugs on the risk of additional NMSCs.
Serotypes of carriage and invasive isolates of Streptococcus pneumoniae in Brazilian children in the era of pneumococcal vaccines
Authors: C.B. Laval, A.L.S.S. de Andrade, F.C. Pimenta, J.G. de Andrade, R.M. de Oliveira, S.A. Silva, E.C. de Lima, J.L. Di Fabio, S.T. Casagrande, M.C.C. Brandileone
Journal: Clinical Microbiology and Infection (2006)
Cardiovascular diseases are responsible for increased plasma NT-proBNP level in obstructive sleep apnoea (OSA) patients
Authors: Robert Plywaczewski, Luiza Jonczak, Przemyslaw Bielen, Dorota Gorecka, Pawel Sliwinski
Journal: European Respiratory Journal (2012)

Untreated OSA is a risk factor for cardiovascular morbidity and mortality. Brain natriuretic peptide (BNP) is a hormone secreted by the ventricles in response to heart overload. The aim of this study was to assess plasma NT-proBNP (inactive form of BNP) in OSA subjects and relationship between hormone level and OSA severity and complications. We studied 1145 OSA pts (859 males-75% and 286 females-25%), mean age - 56.4±10.4 years, AHI – 39.6±21.6, BMI - 34,2±6,4 kg/m 2 . Increased NT-proBNP (> 125 pg/ml) was found in 294 subjects (25.7%). Comparison of OSA subjects with normal and elevated NT-proBNP is shown in a table.  Logistic regression analysis revealed that heart failure (OR- 4.4; 95%CI – 4.09-4.74; p  Conclusions: Increased plasma NT-proBNP concentration in OSA subjects was mainly related to cardiovascular diseases.
Use of Ultrasound Localization to Improve Results of Fine Needle Aspiration Cytology of Breast Masses
Authors: J J Patel, P C Gartell, P B Guyer, A Herbert, I Taylor
Journal: Journal of the Royal Society of Medicine (1988)

A prospective randomized controlled trial of 116 patients with breast masses was conducted to compare the accuracy of ‘blind’ aspiration cytology performed in the clinic with aspiration cytology using ultrasound localization. The unsatisfactory aspiration cytology rate was significantly reduced by ultrasound localization (P=0.028). This was mainly due to an improvement in the unsatisfactory rate for tumours less than 3 cm in diameter (P=0.036). The results were influenced by the number of needle manoeuvres performed, &lt; 10 needle manoeuvres being associated with a 54% unsatisfactory aspiration rate compared with 25% when &gt; 10 manoeuvres were performed (P= &lt;0.02). One experienced aspirator in the clinic had results comparable to those achieved with ultrasound localization. It is concluded that experience and technique are the most important factors in obtaining a satisfactory aspirate from breast masses. Routine ultrasound localization prior to aspiration confers some benefit. Consideration should be given to the use of the ultrasound-assisted technique following a previous unsatisfactory aspiration, particularly if the tumour is less than 3 cm in diameter.
Reactions Between Activated Benzo[ a ]pyrene and Nucleophilic Compounds, With Possible Implications on the Mechanism of Tumor Initiation 2
Authors: E. Cavalieri, R. Auerbach
Journal: JNCI Journal of the National Cancer Institute (1974)

Journal Article Reactions Between Activated Benzo[a]pyrene and Nucleophilic Compounds, With Possible Implications on the Mechanism of Tumor Initiation Get access E. Cavalieri, E. Cavalieri Search for other works by this author on: Oxford Academic PubMed Google Scholar R. Auerbach R. Auerbach Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 53, Issue 2, August 1974, Pages 393–397, https://doi.org/10.1093/jnci/53.2.393 Published: 01 August 1974 Article history Received: 03 July 1973 Revision received: 11 January 1974 Accepted: 23 April 1974 Published: 01 August 1974
Prevalence and Effect of Cyberbullying on Children and Young People
Authors: Michele P. Hamm, Amanda S. Newton, Annabritt Chisholm, Jocelyn Shulhan, Andrea Milne, Purnima Sundar, Heather Ennis, Shannon D. Scott, Lisa Hartling
Journal: JAMA Pediatrics (2015)

Social media has had a profound effect on how children and adolescents interact. While there are many benefits to the use of social media, cyberbullying has emerged as a potential harm, raising questions regarding its influence on mental health.To review existing publications that examine the health-related effects of cyberbullying via social media among children and adolescents.We searched 11 electronic databases from January 1, 2000, through January 17, 2012 (updated June 24, 2014). Studies were screened by 2 independent reviewers and were included if they reported primary research, described or evaluated the use of a social media tool in the context of cyberbullying, and were conducted with children or adolescents. Data were extracted by 1 reviewer and verified by a second. All studies were assessed by 2 reviewers for methodological quality using the Mixed Methods Appraisal Tool. Results were not pooled owing to heterogeneity in study objectives and outcomes; a narrative analysis is presented.Thirty-six studies in 34 publications were included. Most were conducted in the United States (21 [58.3%]), sampled middle and high school populations (24 [66.7%]), and included adolescents who were 12 to 18 years of age (35 [97.2%]). The median reported prevalence of cyberbullying was 23.0% (interquartile range, 11.0%-42.6%). Five studies reported inconsistent and/or weak correlations between cyberbullying and anxiety. Ten studies found a statistically significant association between cyberbullying and report of depression. Five studies investigated self-harm or suicidality, with conflicting results. Results indicate that the most common reason for cyberbullying is relationship issues, with girls most often being the recipients. Responses to cyberbullying are most often passive, with a pervasive lack of awareness or confidence that anything can be done.There is a consistent relationship across studies between cyberbullying and depression among children and adolescents; however, the evidence of the effect of cyberbullying on other mental health conditions is inconsistent. This review provides important information that characterizes cyberbullying within the context of social media, including attributes of the recipients and perpetrators, reasons for and the nature of bullying behaviors, and how recipients react to and manage bullying behaviors. This information is critical to the development of effective prevention and management strategies.
Equivalency of Endothelial Cell Growth Supplement to Irradiated Feeder Cells in Carcinogen-Induced Morphologic Transformation of Syrian Hamster Embryo Cells
Authors: C H Evans, J A DiPaolo
Journal: JNCI Journal of the National Cancer Institute (1982)

Endothelial cell growth supplement (ECGS), an extract of bovine neural tissue with growth-promoting properties for human endothelial and epithelial cells and for mouse BALB/c fibroblast-like cells, can be substituted for feeder cells in a quantitative 7-day Syrian hamster embryo cell colony in vitro model of carcinogenesis. Inclusion of 50 or 100 micrograms ECGS/ml medium throughout the 7-day growth period produced results equal to those obtained with feeder cells. The frequency and morphology of normal fibroblast colonies and carcinogen-induced morphologically transformed cell colony growth in the presence of ECGS were similar to those in the presence of feeder cells. A positive dose-response relationship in transformation by benzo[a]pyrene occurred. The frequency of transformed colonies following UV irradiation and treatment of the cells with the cocarcinogenic tumor promoter 12-O-tetradecanoylphorbol 13-acetate was greatly augmented, and lymphotoxin, a lymphokine with anticarcinogenic activity, reduced transformation. Thus ECGS can substitute for feeder cells in supporting in vitro transformation and eliminates a potential complex source of variability for studies where interaction(s) with feeder cells are a consideration. The mechanics of this model system was simplified, and its versatility for the study of physiologic, carcinogenic, and other pathophysiologic processes was broadened.
Filaggrin loss-of-function mutation R501X and 2282del4 carrier status is associated with fissured skin on the hands: results from a cross-sectional population study
Authors: J.P. Thyssen, K. Ross-Hansen, J.D. Johansen, C. Zachariae, B.C. Carlsen, A. Linneberg, H. Bisgaard, C.G. Carson, N.H. Nielsen, M. Meldgaard, P.B. Szecsi, S. Stender, T. Menné
Journal: British Journal of Dermatology (2011)

Filaggrin metabolites act as osmolytes and are important for skin hydration. Carriers of filaggrin loss-of-function mutations have a higher prevalence of atopic dermatitis and dry skin. There is also evidence to suggest that filaggrin mutations increase the risk of hand eczema in atopic individuals. In our clinic, we have observed a distinct phenotype of hand eczema in patients with filaggrin mutation carrier status, characterized by fissured dermatitis on the dorsal aspect of the hands and with only sparse involvement of the palms including fine scaling.To investigate whether filaggrin loss-of-function mutations are associated with skin fissures on the hands and/or fingers in the general population.Participants in a population-based study were questioned about skin symptoms, genotyped for filaggrin mutation, patch tested for nickel allergy and skin prick tested.In an adjusted logistic regression analysis, filaggrin mutation status was significantly associated with fissured skin on the hands and/or fingers in adults (odds ratio 1·93, 95% confidence interval 1·05-3·55) and showed a nearly significant negative interaction with atopic dermatitis (P=0·055), suggesting that the effect was predominantly in subjects without atopic dermatitis.Filaggrin loss-of-function mutations seem not only to increase the risk of atopic dermatitis and dry skin but also the risk of fissures on the hands and/or fingers in subjects without atopic dermatitis. Prophylactic emollient therapy should be particularly encouraged in filaggrin loss-of-function mutation carriers.
The blaSHV-5 gene is encoded in a compound transposon duplicated in tandem in Enterobacter cloacae
Authors: U. Garza-Ramos, G. Davila, V. Gonzalez, C. Alpuche-Aranda, V.R. López-Collada, D. Alcantar-Curiel, O. Newton, J. Silva-Sanchez
Journal: Clinical Microbiology and Infection (2009)
Purification and Characterization of a Human Lung Tumor-Associated Antigen&lt;xref ref-type="fn" rid="FN1"&gt;2&lt;/xref&gt;
Authors: J A Braatz, K R McIntire, G L Princler, K H Kortright, R B Herberman
Journal: JNCI Journal of the National Cancer Institute (1978)

A human lung tumor-associated antigen was purified from a saline extract of a lung adenocarcinoma. The antigen was demonstrated in extracts of lung adenocarcinoma. The antigen was demonstrated in extracts of lung tumors with the use of an absorbed antiserum by double-diffusion immunoprecipitation. The antiserum did not react with extracts of normal lung or other normal tissues, and the antigen was immunologically distinct from other tumor-associated antigens. Purification was achieved by antibody affinity chromatography and preparative polyacrylamide gel electrophoresis. Isolation procedures were monitored by immunoreactivity with absorbed monospecific antiserum. The antigen was labeled with 125I and judged homogeneous by 1) polyacrylamide gel elecrophoresis in detergent and nondetergent gels, 2) molecular sieve chromatography, 3) ion exchange chromatography, and 4) sucrose gradient sedimentation analysis. A molecular weight of 77,000 was calculated from the s20.w value of 4.24S and from the D20.w value of 5.0X10(-7) cm2/sec. Sodium dodecyl sulfate gel electrophoresis indicated a subunit molecular weight of 42,000. The Stokes radius of the antigen was 40 A and the frictional ratio was 1.42, indicating a nonspherical molecule. The purified radioiodinated antigen could be quantitatively precipitated with specific antiserum.