THE ROLE OF LEUKOCYTE AND PLATELET ANTIBODY TESTS IN MANAGEMENT OF DIVERSE CLINICAL DISORDERS
Authors: J L TULLIS
Journal: Annals of Internal Medicine (1961)

Article1 June 1961THE ROLE OF LEUKOCYTE AND PLATELET ANTIBODY TESTS IN MANAGEMENT OF DIVERSE CLINICAL DISORDERSJAMES L. TULLIS, M.D., F.A.C.P.JAMES L. TULLIS, M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-54-6-1165 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptIt has been known for more than 50 years that heterologous platelet antibodies can induce experimental thrombocytopenic purpura1-3 and that iso-immune leukocyte antibodies can lead to pyrogenic and urticarial transfusion reactions.4 Yet surprisingly little attempt was made to transfer these concepts to clinical states of leukopenia and thrombocytopenia until Oliva and Burbetta5 in 1944 and Evans et al.6 in 1948 showed in vitro evidence of cytotoxic substances in plasma, and Harrington et al.7 shortly thereafter found profound in vivo thrombocytopenic activity of plasma from a patient with idiopathic thrombocytopenic purpura.These latter studies were soon followed by the development of...Bibliography1. 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Author, Article, and Disclosure InformationAffiliations: Boston, Massachusetts*Received for publication December 29, 1960.From The Protein Foundation, Cambridge, Mass.; the New England Deaconess Hospital, Boston, Mass.; and the Department of Medicine, Harvard Medical School, Boston, Mass.†This work was supported by Grant H-2440 from the National Institutes of Health, by grants from the Kresge Foundation and other charitable trusts, and by contributions from industries interested in the alleviation and cure of human disease.Requests for reprints should be addressed to James L. Tullis, M.D., 281 South St., Jamaica Plain 30, Mass. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byAgranulocytosis associated with flucytosine for urinary candidiasisLeukopenien und AgranulocytosenMyeloidLeukocyte agglutinins in workers exposed to benzene, toluene and xyleneBIBLIOGRAPHYThe Platelet Destruction Site in Thrombocytopenic PurpurasDrug-Induced blood dyscrasiasEditorialWhite Blood Cell DisordersSplenectomy in hematologic disorders 1 June 1961Volume 54, Issue 6Page: 1165-1180KeywordsBlood plasmaHospital medicineIdiopathic thrombocytopenic purpuraLymphomaPlateletsProteins ePublished: 1 December 2008 Issue Published: 1 June 1961 PDF downloadLoading ...