tbuckley/cabot-search huggingface dataset:
THE GUARANTEE OF SAFETY IN THE MARRIAGE CONTRACT.
Authors: A. DUEHRSSEN
Journal: JAMA (1906)

In the address of your chairman a sentence is contained which I should like to use as a motto for my short remarks: Sanitary science prevents injury to another, even inadvertently. Therefore it is the self-evident duty of a man entering into matrimony to show a medical certificate proving that he is in good physical and mental health. This demand is particularly necessary in the case of men who have indulged in sexual intercourse before marrying. But I doubt very much whether such a certificate is sufficient with regard to gonorrhea. I could mention many cases from my own practice in which men who had acquired gonorrhea five, ten or even fifteen years before, infected their wives, though they had been declared perfectly healthy by eminent specialists. And the cases of which I speak were not simply catarrhs of the uterus and the vagina, but cases of pyosalpinx and abscess
Sodium Phosphate Enemas: How to Kill Cats, Cause Cardiac Arrest, and Cure Eye Rolling at Stanford
Authors: Clarke E. Atkins
Journal: JAMA (1987)

<h3>To the Editor.—</h3> The continuing reports of intoxication following administration of commercial hypertonic sodium phosphate enema solution in both the human<sup>1,2</sup>and veterinary<sup>3</sup>literature and the recent comment on the lack of animal studies of sodium phosphate enema intoxication prompt me to write. In a recent study,<sup>4</sup>we systematically evaluated alterations in acid-base, fluid, and electrolyte balance after administration of hypertonic sodium phosphate enemas to normal adult cats. <h3>Study.—</h3> Ten awake cats, in whom arterial catheters had been previously implanted, were divided into two groups. Group A received 60 mL (mean dose, 18 mL/kg) of hypertonic sodium phosphate enema solution and group B received 120 mL (mean dose, 32 mL/kg) of hypertonic sodium phosphate enema solution, both with five minutes' forced retention. Abnormalities, noted as early as 15 minutes following administration of enema solution, included severe hyperphosphatemia, mild hypernatremia, hyperglycemia, hypocalcemia, lactic acidosis with an increased anion
A novel missense mutation in tumour necrosis factor receptor superfamily 1A (<i>TNFRSF1A</i>) gene found in tumour necrosis factor receptor-associated periodic syndrome (TRAPS) manifesting adult-onset Still disease-like skin eruptions: report of a case and review of the Japanese patients
Authors: M. Nakamura, M. Kobayashi, Y. Tokura
Journal: British Journal of Dermatology (2009)

Conflicts of interest: none declared. Sir, Tumour necrosis factor receptor (TNFR)‐associated periodic syndrome (TRAPS) is a rare autosomal dominant disorder characterized by recurrent episodes of fever, myalgia, abdominal pain, conjunctivitis and skin eruptions.1 The most common cutaneous manifestation is a centrifugal migratory, erythematous patch overlying the area with myalgia. Less frequently, urticaria‐like plaques and generalized serpiginous patches and plaques occur. Mutations in the TNFRSF1A (TNFR superfamily 1A) gene are responsible for TRAPS.2 Most of the reported mutations reside in exons 2, 3 and 4, which code the extracellular portion of TNFRSF1A. The mutations result in defective shedding of surface TNFR, leading to the long‐lasting activation of TNF signals. Herein, we report a case of TRAPS showing a novel mutation in the TNFRSF1A gene. A 17‐year‐old Japanese female patient was referred to us due to high fever and erythema. For the last 3 months, she had had recurrent high fever up to 39 °C with arthralgia lasting for 5–7 days. However, she had no history of myalgia, conjunctivitis, chest or abdominal pain. The patient had no family history of recurrent high fever or arthralgia.
A New Approach to the Treatment of Asthma
Authors: John A. Oates, Alastair J.J. Wood, Peter J. Barnes
Journal: New England Journal of Medicine (1989)

ASTHMA affects more than 5 percent of the population in industrialized countries, yet it is underdiagnosed and undertreated. There is evidence that the prevalence and severity of asthma are rising.1 The number of deaths from asthma may also be rising,2 3 4 5 contrary to the trend for other common treatable conditions.6 These alarming increases are occurring despite a marked increase in prescribed asthma therapy,7 , 8 which suggests that currently available therapy is inadequate or is not being used optimally. In the past, attention has been concentrated on bronchoconstrictor mechanisms and possible abnormalities of airway smooth muscle in asthma, with consequent emphasis on bronchodilator . . .
Grodzinsky's latest stand – or, just how specific are “lesion-specific” deficits?
Authors: Frederic Dick, Elizabeth Bates
Journal: Behavioral and Brain Sciences (2000)

Deficits observed in Broca's aphasia are much more general than Grodzinsky acknowledges. Broca's aphasics have a broad range of problems in lexical and morphological comprehension; furthermore, the classic “agrammatic” syntactic profile is observed over many populations. Finally, Broca's area is implicated in the performance of many linguistic and nonlinguistic tasks.
Mutations in LGI1 cause autosomal-dominant partial epilepsy with auditory features
Authors: Sergey Kalachikov, Oleg Evgrafov, Barbara Ross, Melodie Winawer, Christie Barker-Cummings, Filippo Martinelli Boneschi, Chang Choi, Pavel Morozov, Kamna Das, Elita Teplitskaya, Andrew Yu, Eftihia Cayanis, Graciela Penchaszadeh, Andreas H. Kottmann, Timothy A. Pedley, W. Allen Hauser, Ruth Ottman, T. Conrad Gilliam
Journal: Nature Genetics (2002)
Hematologic Aspects of Arsenic Intoxication
Authors: Robert A. Kyle, Gertrude L. Pease
Journal: New England Journal of Medicine (1965)

HEMATOLOGIC abnormalities from the organic arsenicals — mainly arsphenamine, neoarsphenamine and oxophenarsine hydrochloride (Mapharsen) — used in antisyphilitic therapy were not uncommon. These consisted of bone-marrow hypoplasia,1 2 3 agranulocytosis4 and thrombocytopenia.5 6 7 Excellent reviews have been published.1 2 3 , 7 In contrast, reports of hematologic abnormalities from inorganic arsenic intoxication have been few and limited in scope. Leukopenia has been the most common finding,8 9 10 11 12 13 14 15 and white-cell counts as low as 600 have been reported.13 Anemia9 , 11 , 15 and thrombocytopenia15 , 16 have been less common.Recently, we have seen 2 patients with chronic arsenic intoxication that was difficult to recognize clinically and took the form of unusual, serious hematologic . . .
Effects of L-Asparaginase in Acute Myelocytic Leukemia
Authors: Takao Ohnuma
Journal: JAMA (1969)

A man with acute myelocytic leukemia was induced into complete remission after a single injection of L-asparaginase 1,000 international units/kg body weight. Nausea, vomiting, fever, weight loss, muscle wasting, hepatic impairment, pancreatitis, hypoinsulinemia, hyperglycemia, fibrinogenopenia, hypocholesterolemia, malabsorption syndrome, and acute brain dysfunctional syndrome developed. These phenomena of L-asparaginase toxicity can be interpreted as induced asparagine deficiency. A "rescue" infusion of L-asparagine was attempted. After relapse eight months later, the patient again attained remission from L-asparaginase.
Platelet Factor 4 Activity against P. falciparum and Its Translation to Nonpeptidic Mimics as Antimalarials
Authors: Melissa S. Love, Melanie G. Millholland, Satish Mishra, Swapnil Kulkarni, Katie B. Freeman, Wenxi Pan, Robert W. Kavash, Michael J. Costanzo, Hyunil Jo, Thomas M. Daly, Dewight R. Williams, M. Anna Kowalska, Lawrence W. Bergman, Mortimer Poncz, William F. DeGrado, Photini Sinnis, Richard W. Scott, Doron C. Greenbaum
Journal: Cell Host & Microbe (2012)
Highlights from the 20th ECCMID
Authors: Peter Hayward, John McConnell
Journal: The Lancet Infectious Diseases (2010)

With about 8000 delegates from 100 countries, this year's European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) in Vienna, Austria (April 10–13) rivaled in size the Interscience Conference on Antimicrobial Agents and Chemotherapy, the major North American infectious diseases meeting.
Screening blood donors by computer interview
Authors: M. P. Wright
Journal: JAMA (1993)

<h3>To the Editor.</h3> —Locke et al<sup>1</sup>demonstrate that potential blood donors yield more data about personal risk factors for the human immunodeficiency virus (HIV) in private computer interviews than they do in response to written questionnaires and face-to-face encounters. As these authors acknowledge, it is now well recognized that patients respond favorably to computer-assisted interviews. The development of computer risk-assessment techniques is a relatively recent endeavor, and knowledge about the validation process for these instruments is at an embryonic stage. At this time, discussion should explore the nature of experimental methods for assessing the accuracy of these techniques. The conventional measures for reporting the accuracy of diagnostic instruments are sensitivity, specificity, and positive and negative predictive value. One's first impulse is to attempt to estimate these measures for risk assessment techniques. Locke et al claim that their computer interview is "more sensitive" than the traditional method. They promise that
Percutaneous Endoscopic Gastrostomy as a Decompressive Technique in Bowel Obstruction due to Abdominal Carcinomatosis
Authors: R. Cannizzaro, F. Bortoluzzi, M. Valentini, C. Scarabelli, E. Campagnutta, M. Sozzi, M. Fornasarig, M. Poletti
Journal: Endoscopy (1995)

Background and Study Aims: Percutaneous endoscopic gastrostomy (PEG) is a simple method of achieving non-surgical gastric decompression in patients suffering from metastatic abdominal tumors and upper gastrointestinal tract obstruction. The aim of this prospective study was both to evaluate the efficacy of PEG for intestinal decompression in patients with disseminated abdominal cancer and to compare two catheters with different diameters.
Measurement of CD4+ Percentage
Authors: Patrick E. Olson
Journal: JAMA (1994)

To the Editor.  —In his Editorial, 1 Dr Volberding notes the stronger correlation between clinical stage and CD4 + percentage than with the absolute CD4 + cell count. He recommends that practitioners switch to use of this more stable marker of progression. To the array of arguments 2 previously advanced for this change should be added simplicity and thrift.  Many clinicians may not be aware of the redundant procedural burden introduced with the process of derivation of absolute CD4 + cell count from CD4 + percentage. Flow cytometry initially determines CD4 + percentage on a blood specimen. A separate white blood cell count and a differential are required to calculate the total CD4 + cell count. High coefficients of variation may be introduced by this additional step, 3 which also increases laboratory costs. As CD4 + evaluation is now suggested every 3 months for patients infected with the human immunodeficiency virus, the US health care system could
Atmospheric metal pollution monitored by spherical moss bags: a case study of Armadale.
Authors: F A Gailey, O L Lloyd
Journal: Environmental Health Perspectives (1986)

To supplement epidemiological investigations into the mortality from respiratory cancer in the small industrial town of Armadale, central Scotland, spherical moss bags were used to study the deposition of atmospheric metal pollution there during a period of 17 months. High concentrations of most metals were found in areas close to the local steel foundry. High concentrations of some metals were also found in the north/northeast of the town. Temporal variations in the metal deposition patterns during the survey-period were observed. By means of statistical analyses, those metals were indicated which were probably emitted from the steel foundry. The scientific and financial advantages of using this method of low technology sampling in epidemiological studies are discussed.
Restraint in Use of High-Dose Fluorides To Treat Skeletal Disorders
Authors: Stephen J. Marx
Journal: JAMA (1978)

There is presently no treatment generally recognized as completely satisfactory for involutional osteoporosis, a condition that may be found in more than 50% of women past age 60 years and in a lesser percent of men in the same age group.<sup>1</sup>This disorder is associated with appreciable morbidity manifested most strikingly as femoral neck fractures or vertebral compression. Many drugs are currently being investigated in an effort to find a useful treatment. Among these drugs are several preparations of inorganic fluoride. Fluorides have also been used for treatment of otospongiosis (otosclerosis), a disorder with osteopenia of the bony capsule of the inner ear.<sup>2</sup>We suspect that in certain settings high-dose fluoride is being used for treatment of involutional osteoporosis and other osteopenic disorders without systematic monitoring for either efficacy or complications of long-term treatment. The purpose of this editorial is to emphasize that fluoride treatment for skeletal disorders
826 ANTIVIRAL TREATMENT OF HCV CARRIERS WITH NORMAL ALT
Authors: C. Puoti, A.M. Pellicelli, M. Romano, R. Guarisco, F. Mecenate, G. Barbarini, E. Mazzoni, A. Barlattani, A. Picardi, A. Paffetti, L. Nosotti, M.E Bonaventura, R. Villani, L. Bellis, S. Nicodemo, L. Spilabotti, F. Soccorsi
Journal: Journal of Hepatology (2008)
Phycomycosis Complicating Leukemia and Lymphoma
Authors: RICHARD D. MEYER
Journal: Annals of Internal Medicine (1972)

During the 10-year period from 1962 to 1971, 26 cases of phycomycosis were diagnosed at Memorial Hospital, New York. This large series enables us to report a significant increase in the incidence of phycomycosis at autopsy. Unlike our experience with aspergillosis, phycomycosis occurred only in patients with leukemias and lymphomas and not in those with carcinomas. Leukopenia was commoner in patients with leukemia and diabetes mellitus with lymphomas. The hallmark of infection was vascular invasion and infarction. Pulmonary involvement was present in 21 of 26 patients. Unusual presentations of phycomycosis included rhinocerebral infection without diabetes mellitus, cavitary pneumonia, and renal vein thrombosis. The commonest suggestive clinical pattern was fever and development or progression of pulmonary infiltrates despite antibiotic therapy. Premortem cultures were uniformly negative. None of the patients survived; suspicion of phycomycosis and earlier diagnosis is discussed in the hope that effective treatment can be given in the immunosuppressed patient.
A Text-Book of Practical Medicine. Designed for the use of Students and Practitioners of Medicine.
Authors: Alfred Lebbeus Loomis
Journal: JAMA (1895)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Conditional disruption of mouse HFE2 gene: Maintenance of systemic iron homeostasis requires hepatic but not skeletal muscle hemojuvelin
Authors: Konstantinos Gkouvatsos, John Wagner, George Papanikolaou, Giada Sebastiani, Kostas Pantopoulos
Journal: Hepatology (2011)

Mutations of the HFE2 gene are linked to juvenile hemochromatosis, a severe hereditary iron overload disease caused by chronic hyperabsorption of dietary iron. HFE2 encodes hemojuvelin (Hjv), a membrane-associated bone morphogenetic protein (BMP) coreceptor that enhances expression of the liver-derived iron regulatory hormone hepcidin. Hjv is primarily expressed in skeletal muscles and at lower levels in the heart and the liver. Moreover, a soluble Hjv form circulates in plasma and is thought to act as a decoy receptor, attenuating BMP signaling to hepcidin. To better understand the regulatory function of Hjv, we generated mice with tissue-specific disruption of this protein in hepatocytes or in muscle cells. The hepatic ablation of Hjv resulted in iron overload, quantitatively comparable to that observed in ubiquitous Hjv-/- mice. Serum iron and ferritin levels, transferrin saturation, and liver iron content were significantly (P < 0.001) elevated in liver-specific Hjv-/- mice. Hepatic Hjv mRNA was undetectable, whereas hepcidin expression was markedly suppressed (12.6-fold; P < 0.001) and hepatic BMP6 mRNA up-regulated (2.4-fold; P < 0.01), as in ubiquitous Hjv-/- counterparts. By contrast, the muscle-specific disruption of Hjv was not associated with iron overload or altered hepcidin expression, suggesting that muscle Hjv mRNA is dispensable for iron metabolism. Our data do not support any significant iron-regulatory function of putative muscle-derived soluble Hjv in mice, at least under physiological conditions.The hemochromatotic phenotype of liver-specific Hjv-/- mice suggests that hepatic Hjv is necessary and sufficient to regulate hepcidin expression and control systemic iron homeostasis.
Intrinsic Anticancer Drug Resistance of Malignant Melanoma Cells Is Abrogated by IFN-β and Valproic Acid
Authors: Wynand P. Roos, Eva Jöst, Christina Belohlavek, Georg Nagel, Gerhard Fritz, Bernd Kaina
Journal: Cancer Research (2011)

Malignant melanoma, once metastasized, has a dismal prognosis because of intrinsic resistance to anticancer drugs. First-line therapy includes the methylating agents dacarbazine and temozolomide. Although DNA mismatch repair and O(6)-methylguanine (O(6)MeG)-DNA methyltransferase (MGMT) are key determinants of cellular resistance to these drugs, there is no correlation between these markers and the therapeutic response in melanoma, indicating as yet unknown mechanisms of drug resistance. We show that in malignant melanoma cells with wild-type p53, the temozolomide-induced DNA damage O(6)MeG triggers upregulation of the Fas/CD95/Apo-1 receptor without activating the apoptosis cascade. This is due to silencing of procaspase-8. A single treatment with IFN-β reactivated procaspase-8 and sensitized melanoma cells to temozolomide. The key role of procaspase-8 in melanoma cell sensitization was verified by experiments in which the death receptor pathway was blocked by expression of dominant-negative FADD, siRNA knockdown of procaspase-8, or stimulation with Fas/CD95/Apo-1 activating antibody. The expression of procaspase-8 could further be enhanced by additional pretreatment with the histone deacetylase inhibitor valproic acid (VPA), which together with IFN-β caused significant sensitization of melanoma cells in vitro. Sensitization of melanoma cells to temozolomide by IFN-β and VPA was also shown in a xenograft mouse model. The data provide a plausible explanation why therapy of malignant melanomas with alkylating anticancer drugs failed even in trials where the repair of the critical toxic lesion O(6)MeG was blocked by MGMT inhibitors and suggest approaches to abrogate intrinsic drug resistance by IFN and VPA-mediated reactivation of the death receptor pathway.
Abstract 177: MiR-10b promotes migration and invasion in pancreatic cancer cells
Authors: Haoxu Ouyang, Murray Korc
Journal: Cancer Research (2012)

Abstract Pancreatic ductal carcinoma (PDAC) is the fourth leading cause of cancer-related death in Unites States. Due to its aggressive local invasion and metastatic nature, the median survival for patients with PDAC is only 6-month. There is therefore an urgent need to improve our understanding of the pathobiology of this malignancy. In this regard, microRNAs (miRs) have emerged as potentially important regulators in PDAC progression by acting on multiple signaling pathways involved in proliferation, apoptosis, invasiveness and metastasis. MiR-10b is an important RNA implicated in the facilitation of cancer cell invasion and metastasis in several cancers. We have previously shown that miR-10b is upregulated in pancreatic cancer cells, and that high levels of miR-10b are associated with decreased time to metastasis following therapy, enhanced resistance to gemcitabine, and decreased overall survival. In the present study, we have sought to characterize the mechanisms of action of miR-10b in PDAC. We found that overexpression of miR-10b promoted migration and invasion of PANC-1 cells in vitro, without enhancing their proliferation. Microarray analysis revealed that TIP30, a tumor and metastasis suppressor, was downregulated by miR-10b overexpression. Validation experiments using luciferase readout assays showed that TIP30 is a direct target of miR-10b. Taken together, these observations suggest that miR-10b plays an important role in PDAC and may be a novel therapeutic target in this deadly malignancy. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 103rd Annual Meeting of the American Association for Cancer Research; 2012 Mar 31-Apr 4; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2012;72(8 Suppl):Abstract nr 177. doi:1538-7445.AM2012-177
L-Selectinhi but not the L-selectinlo CD4+25+ T-regulatory cells are potent inhibitors of GVHD and BM graft rejection
Authors: Patricia A. Taylor, Angela Panoskaltsis-Mortari, Jessica M. Swedin, Philip J. Lucas, Ronald E. Gress, Bruce L. Levine, Carl H. June, Jonathan S. Serody, Bruce R. Blazar
Journal: Blood (2004)
Presence of N regions in the clonotypic DJ rearrangements of the immunoglobulin heavy-chain genes indicates an exquisitely short latency in t(4;11)-positive infant acute lymphoblastic leukemia
Authors: Karin Fasching, Simon Panzer, Oskar A. Haas, Arndt Borkhardt, Rolf Marschalek, Frank Griesinger, E. Renate Panzer-Grümayer
Journal: Blood (2001)
Relationship Between Pulmonary Artery Pressure and Catheter Position
Authors: MELVIN M. SCHEINMAN
Journal: Circulation (1973)

EDITORpatients with regard to more than 2 mm ST depression during submaximal treadmill stress tests, and if so, what percentage of this subgroup had main left coronary artery obstruction on coronary angiography?Admitted- ly, only 11 patients in their group had main left coronary disease so that the statistical significance of such an observation might be questioned.Nevertheless, if most patients with greater than 2 mm of ST depression on exercise stress testing have main left coronary disease demonstrated by coronary angiogra- phy, this subgroup of patients with coronary artery disease could be better suspected prior to coronary angiography.Because of the poor natural history, even asymptomatic patients with a prior myocardial infarc- tion or prior angina should probably have coronary angiography performed and coronary vascular surgery if main left disease is demonstrated.It would also be useful for the coronary angiographer to be forewarned of the likelihood of main left coronary artery disease since Cohen's series demonstrated an approximately 15% mortality of the cardiac catheterization procedure alone.