GENERAL SANARELLI-SHWARTZMAN PHENOMENON WITH FATAL OUTCOME FOLLOWING TYPHOID VACCINE THERAPY
Authors: Erich Urbach, Harold L. Goldburgh, Philip M. Gottlieb
Journal: Annals of Internal Medicine (1944)

Case Reports1 June 1944GENERAL SANARELLI-SHWARTZMAN PHENOMENON WITH FATAL OUTCOME FOLLOWING TYPHOID VACCINE THERAPYERICH URBACH, M.D., F.A.C.A., HAROLD L. GOLDBURGH, M.D., F.A.C.P., PHILIP M. GOTTLIEB, M.D., F.A.C.A.ERICH URBACH, M.D., F.A.C.A.Search for more papers by this author, HAROLD L. GOLDBURGH, M.D., F.A.C.P.Search for more papers by this author, PHILIP M. GOTTLIEB, M.D., F.A.C.A.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-20-6-989 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptInstances of sudden death after intravenous typhoid vaccine therapy have appeared sporadically in the literature (Hench,1 Cecil,2 Ziskind and Schattenberg,3 Lewis,4 Russel5). No uniform opinion exists concerning the mechanisms responsible for death. A number of possibilities have been considered by various authors: (1) disturbances of the neurovascular system (acute vasomotor collapse) (Cecil2), hyperpyrexia (Russel5), (2) vascular changes (disturbances in the capillary permeability), chemical changes leading to acute thrombosis (Hench1), (3) stimulation of inflammatory foci of infectious origin (Hench1), (4) anaphylactic shock (Ziskind and Schattenberg,3 Russel5).On the basis of the case reported herein and the experimental work of Sanarelli6and...Bibliography1. HENCH PS: Usual and unusual reactions to protein (fever) therapy, Arch. Int. Med., 1932, xlix, 1. CrossrefGoogle Scholar2. CECIL RL: Non-specific protein therapy, Jr. Am. Med. Assoc., 1935, cv, 1846. CrossrefGoogle Scholar3. ZISKINDSCHATTENBERG JHJ: Fatal anaphylaxis shock in man, Arch. Int. Med., 1938, lxii, 813. CrossrefGoogle Scholar4. LEWIS PM: Dangers from non-specific protein therapy, South. Med. Jr., 1941, xxxiv, 660. CrossrefGoogle Scholar5. RUSSEL JL: Report of two deaths from third inoculation with typhoid, para-typhoid vaccine, Kentucky Med. Jr., 1924, xxii, 378. Google Scholar6. SANARELLI G: Les Entéropathies Microbiennes, 1926, Mason, Paris. Google Scholar7. SHWARTZMAN G: Phenomenon of local tissue reactivity, 1937, P. B. Hoeber, New York. Google Scholar8. URBACHGOLDBURGH EHL: Hemorrhagic necrotic reaction to tuberculin P. P. D. Shwartzman or Arthus phenomenon? Am. Rev. Tuberc., 1942, xlvi, 418. Google Scholar9. ALBUS J: Das Shwartzman-phänomen in seiner Bedeutung für die ärztliche Praxis, Zentralbl. f. inn. Med., 1937, lviii, 801. Google Scholar10. URBACH E: Heteroallergy: parallergy and metallergy, Arch. Pediat., 1941, lviii, 780. Google Scholar11. ALECHINSKY A: Localisation experimentale de la suffusion sanguine dans le phenomene hemorragique de Sanarelli-Shwartzman, Proc. Internat. Congress Microbiol., 1940, p. 760. Google Scholar12. WEINBERGGOLDSTEIN JHH: Modification of the use of typhoid vaccine in production of hyperpyrexia, Illinois Med. Jr., 1941, lxxix, 139. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Philadelphia, Pa.*Received for publication July 28, 1942.From the Jewish Hospital, Philadelphia, Allergy Department (Dr. E. Urbach) and Medical Department (Dr. H. L. Goldburgh). PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byEndotoxins in commercial vaccinesPNEUMOCOCCAL SEPSIS WITH GENERALISED SHWARTZMAN REACTIONThe Defibrination Syndrome: Clinical Features and Laboratory DiagnosisA Case of Renal Cortical Necrosis Probably Caused by a Human Equivalent of the Shwartzman ReactionExperimentelle Untersuchungen �ber die hormonale Beeinflussung toxisch-infekti�ser GewebsreaktionenTHE SHWARTZMAN PHENOMENON: A REVIEW WITH A CONSIDERATION OF SOME POSSIBLE DERMATOLOGICAL MANIFESTATIONS.Fatal reaction following intravenous 10 per cent dextroseHEMORRHAGIC MANIFESTATIONS OF BACTERIAL AND VIRUS INFECTIONS: EXPERIMENTAL STUDIES AND PATHOLOGICAL INTERPRETATIONS 1 June 1944Volume 20, Issue 6Page: 989-994KeywordsAllergy and immunologyCapillariesShockThrombosisTyphoidVaccinesVascular permeability ePublished: 1 December 2008 Issue Published: 1 June 1944 PDF downloadLoading ...