tbuckley/cabot-search huggingface dataset:
Nanoparticles Targeted With NGR Motif Deliver c-myc siRNA and Doxorubicin for Anticancer Therapy
Authors: Yunching Chen, Jinzi J Wu, Leaf Huang
Journal: Molecular Therapy (2010)

We have designed a PEGylated LPD (liposome-polycation-DNA) nanoparticle for systemic, specific, and efficient delivery of small interfering RNA (siRNA) into solid tumors in mice by modification with NGR (aspargine–glycine–arginine) peptide, targeting aminopeptidase N (CD13) expressed in the tumor cells or tumor vascular endothelium. LPD-PEG-NGR efficiently delivered siRNA to the cytoplasm and downregulated the target gene in the HT-1080 cells but not CD13− HT-29 cells, whereas nanoparticles containing a control peptide, LPD-PEG-ARA, showed only little siRNA uptake and gene silencing activity. LPD-PEG-NGR efficiently delivered siRNA into the cytoplasm of HT-1080 xenograft tumor 4 hours after intravenous injection. Three daily injections (1.2 mg/kg) of c-myc siRNA formulated in the LPD-PEG-NGR effectively suppressed c-myc expression and triggered cellular apoptosis in the tumor, resulting in a partial tumor growth inhibition. When doxorubicin (DOX) and siRNA were co-formulated in LPD-PEG-NGR, an enhanced therapeutic effect was observed. We have designed a PEGylated LPD (liposome-polycation-DNA) nanoparticle for systemic, specific, and efficient delivery of small interfering RNA (siRNA) into solid tumors in mice by modification with NGR (aspargine–glycine–arginine) peptide, targeting aminopeptidase N (CD13) expressed in the tumor cells or tumor vascular endothelium. LPD-PEG-NGR efficiently delivered siRNA to the cytoplasm and downregulated the target gene in the HT-1080 cells but not CD13− HT-29 cells, whereas nanoparticles containing a control peptide, LPD-PEG-ARA, showed only little siRNA uptake and gene silencing activity. LPD-PEG-NGR efficiently delivered siRNA into the cytoplasm of HT-1080 xenograft tumor 4 hours after intravenous injection. Three daily injections (1.2 mg/kg) of c-myc siRNA formulated in the LPD-PEG-NGR effectively suppressed c-myc expression and triggered cellular apoptosis in the tumor, resulting in a partial tumor growth inhibition. When doxorubicin (DOX) and siRNA were co-formulated in LPD-PEG-NGR, an enhanced therapeutic effect was observed.
Can We Prevent Heart Disease?
Authors: Lars Werkö
Journal: Annals of Internal Medicine (1971)

Prevention of heart disease is critically reviewed. Although several risk factors have been identified that seem to characterize individuals most prone to later development of ischemic heart disease, no one has been able to show that interfering with these risk factors will decrease the incidence of the disease. A current population study indicates that removal of only one risk factor may have little or no impact on the overall morbidity or mortality in middle-aged men in Western societies. A multifactorial approach seems necessary to influence a disease that, like ischemic heart disease, is influenced by many environmental factors. The hypothesis that removal of several risk factors will decrease the incidence of ischemic heart disease in the community must be tested before any large-scale changes are advocated in our life style. Such a study is described. Changing social structure in the community, however, may be of larger importance for the prevention of ischemic heart disease than any medical intervention.
β-Blockade in Older Patients With Myocardial Infarction
Authors: Joël Belmin
Journal: JAMA (1992)

<h3>To the Editor.</h3> —From their retrospective study in Beth Israel Hospital, Forman and Wei<sup>1</sup>concluded that the agerelated decrease in use of β-blockers in elderly patients with myocardial infarction was out of proportion to the prevalence of contraindications to these drugs. However, their data indicated the opposite. They in fact showed that this age-related decrease seems to be entirely related to a higher prevalence of contraindications in the older groups. The percentage of patients receiving β-blockers when expressed as a function of patients with no contraindications ("patients without problems") was similar in all age groups or was even higher in the septuagenarian group: 38.4% among those aged 50 through 59 years, 37.4% among those aged 60 through 69 years, 40.5% among those aged 70 through 79 years, and 36.7% among those older than 80 years. Finally, among their patients older than 50 years with myocardial infarction and no contraindication
Cerebellar Vermis Relative Hypermetabolism: An Almost Constant PET Finding in an Injured Brain
Authors: Andrea Lupi, Giannettore Bertagnoni, Matteo Salgarello, Piergiuseppe Orsolon, Veronica Malfatti, Pierluigi Zanco
Journal: Clinical Nuclear Medicine (2007)

Cortical alterations of brain metabolism, as seen in PET, obviously depend on the nature of the damage (either mechanical, toxic, anoxic, or other). However, some subcortical abnormalities seem to occur rather frequently regardless of the extension, position and cause of the damage. In particular, relative cerebellar vermis activation seems to be frequently encountered. The aim of this work was to determine the incidence of this pattern in a heterogeneous population of brain trauma, and to compare it on a quantitative basis with a group of age-sex matched controls. The case records of this study consist of 58 consecutive patients, 44 males, 14 females, age 14-69 (median 34) 44 traumatic, 8 anoxic, 4 vascular and 2 toxic injuries. In the trauma group, the visualization of the cerebellar vermis was readily appreciable as a consistent majority of cases. In particular, the mean vermis/cerebellum ratio (calculated by appropriate ROI positioning) was 1.26 +/- 0.17 SD (range 0.92-1.82); in the control group the same parameters showed much less dispersion: average 0.92 +/- 0.06, range 0.80-1.10 (P < 0.005). If, on the basis of the normal group data, a cut-off value of 1 is accepted for the v/c ratio, it is noted that 54/57 trauma patients (95%) showed a ratio above this value. In conclusion, a hypermetabolic cerebellar vermis is a common finding in a damaged brain, regardless of the nature of the trauma (probably due to the relative preservation compared with other structures of alternative metabolic pathways), and seems to be the hallmark of the injured brain.
Photodynamic Therapy: A Multifunctional Probe with Aggregation‐Induced Emission Characteristics for Selective Fluorescence Imaging and Photodynamic Killing of Bacteria Over Mammalian Cells (Adv. Healthcare Mater. 5/2015)
Authors: Meng Gao, Qinglian Hu, Guangxue Feng, Nikodem Tomczak, Rongrong Liu, Bengang Xing, Ben Zhong Tang, Bin Liu
Journal: Advanced Healthcare Materials (2015)

A multifunctional probe is developed by B. Liu and co-workers on page 659 for selective fluorescence imaging and photodynamic killing of both Gram-positive and -negative bacteria over mammalian cells. Based on its aggregation-induced emission and excited-state intramolecular proton transfer characteristics, the probe is weakly emissive in aqueous solution, but shows intense fluorescence upon binding to negatively charged bacterial membranes. The antibacterial activity arises from both the dark-toxicity and the phototoxicity under white light irradiation.
Managed Care, Outcomes, and Quality: A Practical Guide
Authors: Eugene C. Rich
Journal: Annals of Internal Medicine (1998)

Medical Writings: Book Notes1 June 1998Managed Care, Outcomes, and Quality: A Practical GuideEugene C. Rich, MDEugene C. Rich, MDCreighton University Medical Center, Omaha, NebraskaSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-128-11-199806010-00033 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail Managed Care, Outcomes, and Quality: A Practical Guide; Isenberg SF; ed. 343 pages. Thieme Medical Publishers; 1998. $59.00 ISBN 0865776873. Order phone 212-683-5088.Field of medicine: Health care administration.Format: Softcover book.Audience: Practicing physicians.Purpose: To help physicians “rescue medicine from the questionable mercies of business and politics …” and to provide information on practice management and socioeconomic issues facing practitioners in the United States.Content: The 23 chapters are organized around four themes: the essentials of managed care and competition, the use of outcomes in a managed care environment, quality, and the physician's response to managed care. Most ... Author, Article, and Disclosure InformationAffiliations: Creighton University Medical Center, Omaha, Nebraska PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 June 1998Volume 128, Issue 11Page: 963-964KeywordsHealth careHealth care qualityHospital medicineQuality improvement ePublished: 15 August 2000 Issue Published: 1 June 1998 Copyright & PermissionsCopyright © 1998 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
New horizons in medical ethics. Who is the patient's friend?
Authors: R Klein, D Pyke, A Smith
Journal: BMJ (1973)

Who is the Patient's Friend?This tape-recorded discussion was devoted to the mechanisms for complaints within the Health Service.In their working papers, circulated before the discussion, Mr. Rudolf Klein, an academic who has written extensively on this topic, argues that the existence of some sort of patient's friend would reduce the number of formal complaints; Dr. David Pyke, a consul-
Prospective randomized trial of intravenous Ciprofloxacin for prevention of bacterial infection in cirrhotic patients with variceal bleeding
Authors: Sung Noh Hong, Min Kyu Rhyu, Jun Hyuk Lee, Moon Suk Choi, Kwang Chul Koh, Young Ho Kim, Jae J. Kim, Sung Woon Paik, Jong Chul Lee, Kwu Wan Choi
Journal: Journal of Hepatology (2002)
Effects of Telephone-Based Peer Support in Patients With Type 2 Diabetes Mellitus Receiving Integrated Care
Authors: Juliana C. N. Chan, Yi Sui, Brian Oldenburg, Yuying Zhang, Harriet H. Y. Chung, William Goggins, Shimen Au, Nicola Brown, Risa Ozaki, Rebecca Y. M. Wong, Gary T. C. Ko, Ed Fisher
Journal: JAMA Internal Medicine (2014)

<h3>Importance</h3> In type 2 diabetes mellitus (T2DM), team management using protocols with regular feedback improves clinical outcomes, although suboptimal self-management and psychological distress remain significant challenges. <h3>Objective</h3> To investigate if frequent contacts through a telephone-based peer support program (Peer Support, Empowerment, and Remote Communication Linked by Information Technology [PEARL]) would improve cardiometabolic risk and health outcomes by enhancing psychological well-being and self-care in patients receiving integrated care implemented through a web-based multicomponent quality improvement program (JADE [Joint Asia Diabetes Evaluation]). <h3>Design, Setting, and Participants</h3> Between 2009 and 2010, 628 of 2766 Hong Kong Chinese patients with T2DM from 3 publicly funded hospital-based diabetes centers were randomized to the JADE + PEARL (n = 312) or JADE (n = 316) groups, with comprehensive assessment at 0 and 12 months. <h3>Interventions</h3> Thirty-three motivated patients with well-controlled T2DM received 32 hours of training (four 8-hour workshops) to become peer supporters, with 10 patients assigned to each. Peer supporters called their peers at least 12 times, guided by a checklist. <h3>Main Outcomes and Measures</h3> Changes in hemoglobin A<sub>1c</sub>(HbA<sub>1c</sub>) level (primary), proportions of patients with attained treatment targets (HbA<sub>1c</sub>&lt;7%; blood pressure &lt;130/80 mm Hg; low-density lipoprotein cholesterol &lt;2.6 mmol/L [to convert to milligrams per deciliter, divide by 0.0256]) (secondary), and other health outcomes at month 12. <h3>Results</h3> Both groups had similar baseline characteristics (mean [SD] age, 54.7 [9.3] years; 57% men; disease duration, 9.4 [7.7] years; HbA<sub>1c</sub>level, 8.2% [1.6%]; systolic blood pressure, 136 [19] mm Hg; low-density lipoprotein cholesterol level, 2.89 [0.82] mmol/L; 17.4% cardiovascular-renal complications; and 34.9% insulin treated). After a mean (SD) follow-up period of 414 (55) days, 5 patients had died, 144 had at least 1 hospitalization, and 586 had repeated comprehensive assessments. On intention-to-treat analysis, both groups had similar reductions in HbA<sub>1c</sub>(JADE + PEARL, 0.30% [95% CI, 0.12%-0.47%], vs JADE, 0.29% [95% CI, 0.12%-0.47%] [<i>P</i> = .97]) and improvements in treatment targets and psychological-behavioral measures. In the JADE + PEARL group, 90% of patients maintained contacts with their peer supporters, with a median of 20 calls per patient. Most of the discussion items were related to self-management. <h3>Conclusions and Relevance</h3> In patients with T2DM receiving integrated care, peer support did not improve cardiometabolic risks or psychological well-being. <h3>Trial Registration</h3> clinicaltrials.gov Identifier:NCT00950716
Plasma Fetuin-A Levels and the Risk of Myocardial Infarction and Ischemic Stroke
Authors: Cornelia Weikert, Norbert Stefan, Matthias B. Schulze, Tobias Pischon, Klaus Berger, Hans-Georg Joost, Hans-Ulrich Häring, Heiner Boeing, Andreas Fritsche
Journal: Circulation (2008)

Fetuin-A, a protein almost exclusively secreted by the liver, induces insulin resistance and subclinical inflammation in rodents. Circulating fetuin-A levels are elevated in humans with metabolic syndrome and insulin resistance, conditions that are associated with increased risk of cardiovascular disease.We investigated the association between fetuin-A levels and the risk of future myocardial infarction (MI) and ischemic stroke (IS) in a case-cohort study based on the European Prospective Investigation into Cancer and Nutrition (EPIC)-Potsdam Study comprising 27 548 middle-aged subjects of the general population. Fetuin-A levels were measured in plasma of 227 individuals who developed MI, in 168 who developed IS, and in 2198 individuals who remained free of cardiovascular events during a mean follow-up of 8.2+/-2.2 years. Individuals in the highest compared with the lowest quintile of plasma fetuin-A had significantly increased risks of MI (relative risk, 3.80; 95% confidence interval, 2.37 to 6.10; P for trend <0.0001) and IS (relative risk, 3.93; 95% confidence interval, 2.17 to 7.12; P for trend <0.0001) after adjustment for sex and age. Additional adjustment for smoking status, body mass index, waist circumference, alcohol consumption, educational attainment, physical activity, hypertension, diabetes mellitus, total and high-density lipoprotein cholesterol, and C-reactive protein only moderately attenuated these risks (MI: relative risk, 3.25; 95% confidence interval, 2.01 to 5.28; P for trend <0.0001; IS: relative risk, 3.78; 95% confidence interval, 2.06 to 6.94; P for trend <0.0001).Our data provide evidence for a link between high plasma fetuin-A levels and an increased risk of MI and IS. Therefore, more research is warranted to determine the role of fetuin-A in the pathophysiology of cardiovascular disease.
TG02, a novel oral multi-kinase inhibitor of CDKs, JAK2 and FLT3 with potent anti-leukemic properties
Authors: K C Goh, V Novotny-Diermayr, S Hart, L C Ong, Y K Loh, A Cheong, Y C Tan, C Hu, R Jayaraman, A D William, E T Sun, B W Dymock, K H Ong, K Ethirajulu, F Burrows, J M Wood
Journal: Leukemia (2011)
Extensive Bullous Emphysema in a Young Woman
Authors: Ronald S. Rankin
Journal: JAMA (1976)

History  A 24-year-old woman had shortness of breath of several months' duration and complained of a cold that lasted all winter, associated with cough. She had smoked one pack of cigarettes per day for five years. Physical examination showed that she breathed through pursed lips and had distant heart sounds. Pulmonary function tests were consistent with severe obstructive airways disease. An aunt and uncle of the patient also complained of chronic dyspnea.  The correct diagnosis was suggested by the roentgenologist from the routine chest films (Fig 1 and 2).  Diagnosis  Antitrypsin, deficiency.  Comment  The chest films show striking pulmonary emphysema with preferential involvement of the lower lobes (Fig 1). Bullae are evident in the anterior clear space on the lateral view (Fig 2). A pulmonary angiogram (Fig 3) demonstrates a dramatic asymmetry of perfusion between the upper and lower lung fields and verifies the severity of involvement in this young
Solitary Cerebriform Nodule—Quiz Case
Authors: Michael Armando Marchetti, Mark Russell
Journal: JAMA Dermatology (2013)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Dermatology HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Dermatology journal
Clinical Usefulness of Home Oximetry Compared with Polysomnography for Assessment of Sleep Apnea
Authors: William A. Whitelaw, Rollin F. Brant, W. Ward Flemons
Journal: American Journal of Respiratory and Critical Care Medicine (2004)

The practical purpose of diagnostic assessment in most cases of obstructive sleep apnea is to predict which patients have symptoms that will improve on treatment. We measured the accuracy with which clinicians make this prediction using polysomnography compared with oximeter-based home monitoring. Patients referred to a sleep center with suspicion of symptomatic obstructive sleep apnea were randomized to have polysomnography or home monitoring. Patients with comorbidity or physiologic consequences of sleep apnea were excluded. Sleep specialists estimated the likelihood of success of treatment as greater than 50% (predicted success) or less than 50% (predicted failure) on the basis of clinical data and test results. All patients were treated for 4 weeks with autoadjusting continuous positive airway pressure. Success was defined as an increase greater than 1.0 in Sleep Apnea Quality of Life Index. Correct prediction rates were compared. Two hundred eighty-eight patients were enrolled. Initial patient characteristics, compliance, and improvement in quality of life at 4 weeks were not different in the two groups. The correct prediction rate was 0.61 with polysomnography and 0.64 with home monitoring (not significant). We conclude that the ability of physicians to predict the outcome of continuous positive airway treatment in individual patients is not significantly better with polysomnography than with home oximeter-based monitoring.
Benefits of implantable cardiac defibrillators in heart failure are confirmed
Authors: Janice Hopkins Tanne
Journal: BMJ (2004)

Implantable cardiac defibrillators significantly reduce mortality in patients with heart failure and impaired left ventricular function, a new study shows.

Dr Gust Bardy of the Seattle Institute for Cardiac Research, Washington, reported the study to the conference.

The sudden cardiac death in heart failure trial (SCD-HeFT) was a randomised controlled trial of an implantable cardiac defibrillator in addition to standard treatment. It reduced mortality by 23% in a five year study of 2521 patients at …
Rijnse Roemer-Reply
Authors: Terrell Hillebrand
Journal: JAMA (1987)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Protecting Childhood in the AIDS Pandemic: Finding Solutions That Work
Authors: Carl C. Bell
Journal: JAMA (2012)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Taking medical histories through interpreters: practice in a Nigerian outpatient department.
Authors: J Launer
Journal: BMJ (1978)

Consultations through interpreters in the medical outpatient department of a Nigerian hospital were tape-recorded. These recordings were translated completely into English and transcribed, and the performance of the interpreters was analysed. The interpreters often did not provide word-for-word translations of what the doctor or patient had said. Some of these deviations were helpful, but others were confusing or incorrect. In particular, interpreters were inclined to conduct much of the consultations themselves. Hospitals using interpreters should ensure that they have no conflicting duties during consultations and that they have some training in language and interpretation. The quality of interpretation should be checked by native-speaking doctors and by using recordings. Doctors using interpreters should try to make sure that everything said is translated and check the patient's answers by asking questions in several ways.
The May-Hegglin anomaly gene MYH9 is a negative regulator of platelet biogenesis modulated by the Rho-ROCK pathway
Authors: Zhao Chen, Olaia Naveiras, Alessandra Balduini, Akiko Mammoto, Mary Anne Conti, Robert S. Adelstein, Donald Ingber, George Q. Daley, Ramesh A. Shivdasani
Journal: Blood (2007)