tbuckley/cabot-search huggingface dataset:
A phase I study of VB6–845, an anti-EpCAM fusion protein targeting advanced solid tumours of epithelial origin: preliminary results
Authors: M. Kowalski, L. Brazas, R. Zaretsky, M. Rasamoelisolo, G. MacDonald, W. Cuthbert, N. Glover
Journal: Journal of Clinical Oncology (2008)

14663 Background: VB6–845 is a recombinant fusion protein comprised of a humanized Fab anti-EpCAM antibody linked to a de- immunized version of the ribosome inactivating protein, bouganin (de-bouganin). EpCAM is highly expressed on carcinoma cells of epithelial origin. VB6–845 targets and mediates cell death in EpCAM-positive tumors. Preliminary results from a phase I trial of VB6–845 systemically administered into patients with advanced epithelial tumours are presented. Methods: Dose cohorts of 3–6 patients with EpCAM- positive advanced epithelial tumours were entered into the study. Patients were treated with VB6–845 via IV infusion, once weekly in 4-week cycles. Patients received treatment until an unacceptable toxicity occurred, all lesions completely disappeared or disease progressed. Doses were escalated from 1.0 mg/kg according to a modified Fibonacci design until 2 out of 3 or 2 out of 6 patients experienced a DLT. The MTD will be reached when <2 out of 6 patients experience a DLT. An additional 12 patients will be enrolled at the MTD for further characterization of VB6–845 at that level. All toxicities were assessed according to the NCI CTC AE v3.0. Blood samples were obtained for safety labs, immunogenicity and pharmacokinetics. Results: To date, 11 patients have been treated with the longest treatment being 14 weeks. Three patients were enrolled at 1.0 mg/kg and dose escalation has proceeded to 2.0 mg/kg. A single DLT of a grade 4 infusion reaction has been observed at the 2.0 mg/kg dose level. The most common toxicities reported included fever, hypotension and hypoalbuminemia. Immunogenicity data (10 patients) reveal anti-de-bouganin levels that are either below or near the limit of detection. Enrollment and testing in the higher dose levels is ongoing. Conclusions: Preliminary results reveal that VB6–845 is well tolerated and demonstrates a markedly attenuated antibody response against the de-bouganin. These results support continued evaluation of VB6–845 as a promising new therapy for advanced solid tumours of epithelial origin. Author Disclosure Employment or Leadership Consultant or Advisory Role Stock Ownership Honoraria Research Expert Testimony Other Remuneration Viventia Biotech
Asthma and allergies in schoolchildren of Maputo
Authors: S. Mavale‐Manuel, O. Joaquim, C. Macome, L. Almeida, E. Nunes, A. Daniel, J. Malichocho, A. Pedro, S. Bandeira, E. Eduardo, L. Maciel, E. Constance, S. Marques, A. Tembe, J. De Blic, I. Annesi‐Maesano
Journal: Allergy (2007)

Aim: The study aimed to determine prevalence and severity of asthma, rhinitis and eczema in Maputo, Mozambique. Methods: The International Study of Asthma and Allergies (ISAAC) protocol was applied in 27 schools in urban, suburban and semi‐rural areas. Results: A total of 2630 completed questionnaires were obtained from students aged 13–14 years, and 2383 from schoolchildren aged 6–7 years. The prevalence of current asthma was 13.3% in the two groups, the prevalence of rhinoconjuctivitis and eczema was 23% and 10% in teenagers and 8.8% and 8.5% respectively in children 6–7 years old. Overall, 35% of the adolescents and 23.8% of children were found to have at least one atopic condition or asthma in the last year. In symptomatic adolescents, the conditions were: rhinoconjuctivitis (41.3%), asthma (20%) and eczema (12.4%). In symptomatic children, asthma was the principal condition (36.2%), followed by eczema (20.3%) and rhinoconjunctivitis (19.1%). In adolescents, asthma was more frequently associated with rhinoconjuctivitis (28%). About 4% of all surveyed children had three atopic conditions associated. In adolescents, past year rhinitis was more frequent and severe in the urban area. Hay fever was commoner in the semi‐urban area. Eczema was significantly more recurrent in suburban and semi‐rural area. Exercise‐induced wheeze, nocturnal cough and ever asthma were more reported in children of suburban area. Conclusion: Asthma and allergic diseases are important public health problems in Maputo and improvement in prevention and management plans are required.
Tamoxifen Chemoprevention—End of the Road?
Authors: Steven A. Narod
Journal: JAMA Oncology (2015)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Oncology HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Oncology journal
Abstract #4433: The effects of EGFR activation and attenuation of the TGF\#946; pathway in an orthotopic model of colon cancer
Authors: Melanie Ongchin, Elizabeth Sharratt, Ivan Dominguez, Jing Wang, Richard Cheney, Charles LeVea, Michael Brattain, Ashwani Rajput
Journal: Cancer Research (2009)

AACR Annual Meeting-- Apr 18-22, 2009; Denver, CO

Introduction: Colorectal cancer is the second leading cause of cancer related mortality in the U.S, with a majority of deaths due to metastatic disease. There have been few in vivo models which allow for the study of metastasis. The purpose of this study was to determine the effects of EGFR activation and attenuation of the TGF\#946; pathway in FET, a weakly tumorigenic human colon cancer cell line, in an orthotopic model. Methods: FET cells were transfected with TGF\#945; cDNA with a tetracycline off promoter to create a tumorigenic line, FET\#945;. FET and FET\#945; were transfected with a Dominant Negative RII construct to form FETDNRII and FET\#945;DNRII. The DNRII construct in FETDNRII also had a Tet off promoter. 7 x 106 cells of each line were injected into BALB/c nude male mice to form xenografts. The xenografts were explanted, cut into 1mm³ pieces and subserosally implanted onto the colons of other male mice. The treated mice had a 3mg/ml tetracycline in 5% glucose solution starting post-operative day 2. Mice were necropsied at 7 weeks. Tissues were formalin fixed and paraffin embedded for HEDNRII and FETDNRII had similar apoptotic rates on TUNEL staining, but when compared to FET\#945;, were significantly decreased. Ki-67 staining showed no proliferative difference amongst the 3 lines. Conclusion: EGFR activation transforms a non-tumorigenic cell line (FET) to a tumorigenic one (FET\#945;). With TGF\#946; pathway attenuation, the tumorigenic line becomes metastatic. Loss of EGFR activation in a TGF\#946; inhibited line results in a decreased metastatic burden, but importantly, alters the organotropic homing from lung to liver in vivo. This is further confirmed by the metastatic pattern of FET\#945;DNRII where the EGFR activation was turned off. Redundancy in survival signaling is suggested by FETDNRII + Tet\#8217;s metastatic ability. Thus, these in vivo models offer a way to study the effects of EGFR activation and TGF\#946; signaling in colorectal metastasis.

Citation Information: In: Proc Am Assoc Cancer Res; 2009 Apr 18-22; Denver, CO. Philadelphia (PA): AACR; 2009. Abstract nr 4433.
Abstract 16307: Connexin-43 Contributes to Transmission of MitoKATP Channel-Derived Redox Signal to Akt-GSK-3{beta} Pathway in Cardiomyocyte Protection Afforded by G-protein Coupled Receptors
Authors: Satoko Ishikawa, Atsushi Kuno, Takayuki Miki, Masaya Tanno, Toshiyuki Yano, Hidemichi Kouzu, Tatsuya Sato, Daisuke Sunaga, Tetsuji Miura
Journal: Circulation (2010)

Background: Connexin-43 (Cx43) in mitochondria reportedly plays a crucial role in activation of the mitochondrial ATP-sensitive K+ channel (mKATP), which triggers reactive oxygen species (ROS)-medi...
Endoscopic Ultrasound-Guided Fine-Needle Aspiration Biopsy of Liver Lesions: Histological and Cytological Assessment
Authors: S. Hollerbach, J. Willert, T. Topalidis, M. Reiser, W. Schmiegel
Journal: Endoscopy (2003)

Background and Study Aims: EUS-guided fine-needle aspiration biopsy (EUS-FNA) is used increasingly for the diagnosis of mediastinal, biliopancreatic, and gastric tumors. However, little is known about EUS-FNA in hepatic lesions and the best method for tissue analysis. We assessed EUS-FNA combined with histological and cytological evaluation in selected patients. Patients and Methods: 41 patients (66 ± 7 years) were prospectively studied, 33 of whom had clinical findings suggestive of liver malignancies. Selection for EUS-FNA was based on an increased risk of bleeding from percutaneous biopsy (coagulopathy, cirrhosis, ascites, aspirin intake; n = 15), presence of small liver tumors < 2 cm (n = 12), or liver lesions found incidentally (n = 14). Transgastric EUS-FNA of lesions located in accessible liver segments was performed using the Hitachi FG-34UX longitudinal echo endoscope and a 22-G aspiration needle. Specimens were submitted separately for standard cytological and histological evaluation. In the case of malignancies, findings at surgery with histological examination, endoscopy, or computed tomography (CT)-guided biopsy of the primary cancer served as reference results (n = 33), while in benign disorders, a combination of imaging studies (Magnetic Resonance Tomography 〈MRT〉, scintigraphy) and the clinical follow-up, as summarized in the physician's report, was used as reference. Results: EUS-FNA provided appropriate biopsy specimens in 40/41 patients. It was not possible to aspirate sufficient material in one patient. On average, 1.4 needle passes were necessary to obtain sufficient amounts of tissue. With regard to malignancy, the combination of histological and cytological examination had a sensitivity of 94 %, specificity of 100 %, negative predictive value (NPV) of 78 %, and positive predictive value (PPV) of 100 %. Tissue diagnoses were in agreement in 27/41 patients (65 %). In the remaining patients, only the cytological examination identified six lesions correctly, while the histological assessment was correct in another seven patients. Malignant lesions were correctly identified by cytology in 24/33 (73 %) patients, while histology alone was diagnostic for malignancy in 27/33 (82 %) patients. When both modalities were combined, 31 out of 33-malignancies (94 %) were correctly diagnosed. Minor complications occurred in two patients and consisted of self-limiting local bleeding. Conclusions: EUS-FNA of liver tumors is a powerful, reliable, and safe procedure for the diagnosis of malignant liver lesions. Optimal diagnostic results are achieved by combining cytological with histological assessment. Hence, EUS-FNA is an alternative to percutaneous biopsy, particularly in patients at risk of bleeding or with small lesions of the liver.
Long-term correction of canine hemophilia B by gene transfer of blood coagulation factor IX mediated by adeno-associated viral vector
Authors: Roland W. Herzog, Edmund Y. Yang, Linda B. Couto, J. Nathan Hagstrom, Dan Elwell, Paul A. Fields, Melissa Burton, Dwight A. Bellinger, Marjorie S. Read, Kenneth M. Brinkhous, Gregory M. Podsakoff, Timothy C. Nichols, Gary J. Kurtzman, Katherine A. High
Journal: Nature Medicine (1999)
Abstract 18475: Vegetation Size Does Not Affect Stroke Risk in Infective Endocarditis After 5 Days of Effective Antimicrobial Therapy: An Analysis From the International Collaboration on Endocarditis-Prospective Cohort Study (ICE-PCS)
Authors: Stuart Dickerman, Bruno Barsic, Arnold Bayer, Enrico Cecchi, Vivian Chu, Anna Lisa Crowley, Christoph Naber, Lawrence Park, Christophe Tribouilloy, Andrew Wang
Journal: Circulation (2010)

Introduction: Previous studies have demonstrated a dramatic reduction in stroke risk in infective endocarditis (IE) soon after the initiation of effective antimicrobial therapy. Other studies have ...
RENAL INSUFFICIENCY FOLLOWING BLOOD TRANSFUSION—RECOVERY AFTER VENESECTION
Authors: Henry T. Vondeesten, Samuel A. Cosgrove
Journal: Annals of Internal Medicine (1933)

Article1 July 1933RENAL INSUFFICIENCY FOLLOWING BLOOD TRANSFUSION—RECOVERY AFTER VENESECTIONHENRY T. VONDEESTEN, M.D., F.A.C.P., SAMUEL A. COSGROVE, M.D., F.A.C.S.HENRY T. VONDEESTEN, M.D., F.A.C.P., SAMUEL A. COSGROVE, M.D., F.A.C.S.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-7-1-105 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptIn 1931, Bordley1 reviewed the literature and analyzed 17 cases of renal insufficiency following blood transfusions. Eleven of these 17 cases died and six recovered. No patient recovered who had received more than 540 c.c. of blood; none died who had received less than 350 c.c. of blood.The present case is reported as unusual, in that recovery followed transfusion of 750 c.c. of blood, and that it seemed to depend on venesection, a measure not evidently used in previous cases reported.CASE REPORTSMrs. B., aged 32, wife of a physician, was the mother of three children, and had...Reference1. BORDLEY J: Reactions following transfusion of blood, with urinary suppression and uremia, Arch. Int. Med., 1931, xlvii, 288-315. CrossrefGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: *Received for publication November 11, 1932. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byNeuzeitliche Sicherungen bei BluttransfusionenA Study of two Transfusion Deaths Due to Rh IncompatibilityAnuria: With special reference to renal failure in blackwater fever, incompatible transfusions, and crush injuries 1 July 1933Volume 7, Issue 1Page: 105-108KeywordsBloodBlood transfusionChildrenPhlebotomy Issue Published: 1 July 1933 PDF downloadLoading ...
Abstract 20799: Assessment of Heart Failure With Preserved Ejection Fraction: An Application of Tissue Doppler Imaging-Derived Myocardial Performance Index
Authors: Hyungseop Kim, Hong-Won Shin, Jihyun Son, Hyuck-Jun Yoon, Hyoung-Seob Park, Yun-Kyeong Cho, Chang-Wook Nam, Seung-Ho Hur, Yoon-Nyun Kim, Kwon-Bae Kim
Journal: Circulation (2010)

Background: In heart failure with preserved ejection fraction (HFPEF), physiological abnormalities are not solely restricted to diastole with systolic function not being completely preserved. Because tissue Doppler imaging (TDI)-derived myocardial performance index (MPI) offers the advantage of recording systolic and diastolic tissue velocity simultaneously in the same cardiac cycle, this study was aimed at determining whether TDI-MPI is an informative index for the assessment of HFPEF compared to conventional echocardiographic parameters. Methods: Among one-seventy nine patients of HFPEF and 49 age-matched healthy controls, cardiac function was evaluated by conventional echocardiography, TDI-velocity and -MPI. In the patients with HFPEF, during the median follow-up of 32 months, clinical outcomes, defined as the composite of cardiovascular death and readmission for HF, were assessed. Results: Mean TDI-MPI was significantly greater in HFPEF group compared with healthy control (0.64 ± 0.26 vs. 0.33 ± 0.07,...
Fiction, Asperger Disorder
Authors: Sarah Ringold
Journal: JAMA (2004)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Does 77→G in PTPRC modify autoimmune disorders linked to the major histocompatibility locus?
Authors: Igor Vorechovsky, Jana Kralovicova, Elma Tchilian, Thomas Masterman, Zhiping Zhang, Berne Ferry, Siraj Misbah, Helen Chapel, David Webster, Dennis Hellgren, Maria Anvret, Jan Hillert, Lennart Hammarstrom, Peter C. Beverley
Journal: Nature Genetics (2001)
Fortnightly Review: Paget's disease of bone: diagnosis and management
Authors: D. Hosking, P. J Meunier, J. D Ringe, J.-Y. Reginster, C. Gennari
Journal: BMJ (1996)

<h3>Summary points</h3> Paget9s disease is a localised monostotic or polyostotic progressive bone disease of uncertain origin (it may be caused by a slow viral infection) It is characterised by increased bone remodelling, leading to pain, fractures, and deformities with the risk of skeletal, articular, or neurological complications Radiography, scintigraphy, and bone biochemistry are useful tools in achieving a positive diagnosis The primary aim of treatment is to reduce pain and the risk of developing long term complications Potent antiresorptive drugs are now available which control the increased bone remodelling and have led to a dramatic improvement in treatment
A revised scoring system for cutaneous lupus erythematosus: the RCLASI
Authors: A. Kreuter
Journal: British Journal of Dermatology (2010)

Journal Article A revised scoring system for cutaneous lupus erythematosus: the RCLASI Get access A. Kreuter A. Kreuter Department of Dermatology, Ruhr‐University Bochum, Gudrunstrasse 56, 44791 Bochum, Germany. E‐mail: a.kreuter@derma.de Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 163, Issue 1, 1 July 2010, Page 3, https://doi.org/10.1111/j.1365-2133.2010.09871.x Published: 01 July 2010
67. Protective Immunity Against Yersinia pestis in Mice Immunized with an Ad-Based Vaccine Vector Expressing the Y. pestis F1 and V Antigens
Authors: Maria Chiuchiolo, Julie L. Boyer, Tiffany Niven, Anja Krause, Neil R. Hackett, Ronald G. Crystal
Journal: Molecular Therapy (2005)

The aerosol form of the bacterium Yersinia pestis causes the pneumonic plague, an extremely virulent and rapidly fatal disease that develops within days post-infection. In the context of a bioterror threat, an effective anti-plague vaccine must elicit rapid, robust and long acting protective immunity after a single dose. At present, no plague vaccines are available for use in the USA. Two subunits of Y. pestis, fraction 1 (F1) and V antigen have been identified as vaccine candidates based on: (1) F1 antigen is a temperature-regulated capsular protein of Y. pestis with anti-phagocytic activity in the host; (2) V antigen has local anti-inflammatory effects and influences the function of important virulence factors such as the Yersinia outer membrane proteins (Yops). It is known that protective immunity against Y. pestis challenge can be induced by multiple immunizations with recombinant F1 and V proteins and immediate protection can be achieved by passive transfer of immune sera against these antigens. Based on the knowledge that adenovirus (Ad) gene transfer vectors act as adjuvants in eliciting host immunity against the transgene they carry, replication-defective Ad gene transfer vectors encoding either the Y. pestis V antigen or the F1 protein (AdsecV and AdsecF1, respectively) were constructed. The F1 and V antigen genes were synthesized by an overlap PCR strategy using mammalian preferred codons, and fused to the human Ig signal sequence for extracellular secretion. We tested the hypothesis that AdsecV and AdsecF1 can stimulate strong protective immune responses without a requirement for repeat administration. To test the efficacy of the vaccines, BALB/c mice were immunized with a single intramuscular administration of either vector at a dose of 108 to 1011 particles units (pu). Four wk after immunization, mice were challenged in a BSL3 experimental animal facility (n=10/group) by the intranasal route with 3103 cfu of the fully virulent Yersinia pestis strain, CO92. At challenge time, anti-V antigen IgG reciprocal titers from AdsecV–immunized mice (n=10/group) were 666137 (108 pu), 3045735 (109 pu), 97032193 (1010 pu), and 7611215914 (1011 pu). In contrast, anti-F1 antigen IgG reciprocal titers from AdsecF1-immunized mice (n=10/group) were much lower with 122 (108 pu), 9135 (109 pu), 1154138 (1010 pu), and 939157 (1011 pu). All (10/10) of the animals survived the Y. pestis challenge in the group vaccinated with 1011 pu AdsecV, and 40% (4/10) survived in the 1010 pu AdsecV dose, while in all the other experimental groups immunized with AdsecV and in the control groups the mice died within 2 to 5 days after challenge. No mice vaccinated with AdsecF1 survived the Y. pestis challenge. These observations suggest that an Ad-based vaccine encoding for the V antigen of Y. pestis (AdsecV) is an excellent candidate as a effective single dose vaccine against the plague.