Oxacillin Hepatotoxicity in HIV-infected Patients
Authors: Bassam Saliba
Journal: Annals of Internal Medicine (1994)

Letters15 June 1994Oxacillin Hepatotoxicity in HIV-infected PatientsBassam Saliba, MD and Peter N. Herbert, MDBassam Saliba, MDHospital of Saint Raphael; New Haven, CT 06510Search for more papers by this author and Peter N. Herbert, MDHospital of Saint Raphael; New Haven, CT 06510Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-120-12-199406150-00018 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:Patients with human immunodeficiency virus (HIV) infection are unusually sensitive to chemical hepatitis caused by trimethoprim-sulfamethoxazole and pentamidine [1, 2]. Our anecdotal observations suggested a similar sensitivity of such patients to oxacillin. To examine this hypothesis, we compared all HIV-infected patients treated for bacterial endocarditis at our hospital between January 1991 and December 1992 with patients not known to be HIV-positive.All patients received oxacillin therapy for at least 10 days or stopped therapy because of hepatotoxicity as defined by an increase in the aspartate or alanine aminotransferase levels to at least three times the upper limit ...References1. Medina I, Mills J, Leoung G, Hopewell PC, Lee B, Modin G, et al. Oral therapy for Pneumocystis carinii pneumonia in the AIDS. N Engl J Med. 1990; 323:776-82. Google Scholar2. Kovacs JA, Hiemenz JW, Macher AM, Stover D, Murray HW, Shelhamer J, et al. Pneumocystis carinii pneumonia: a comparison between patients with the acquired immunodeficiency syndrome and patients with other immunodeficiencies. Ann Intern Med. 1984; 100: 663-71. Google Scholar3. Manzo RH. de Bertorello MM. Isoxazoles. II. Kinetics and mechanism of degradation of sulfisoxazole in moderately concentrated acids. J Pharm. Sci. 1973; 62:154-8. Google Scholar4. van der Ven AJ, Koopmans PP, Vree TB, van der Meer JW. Adverse reactions to co-trimoxazole in HIV infection. Lancet. 1991; 338:431-3. Google Scholar5. Buhl R, Jaffe HA, Holroyd KJ, Wells FB, Mastrangeli A, Saltini C, et al. Systemic glutathione deficiency in symptom-free HIV seropositive individuals. Lancet 1989; 2:1294-98. Google Scholar Author, Article, and Disclosure InformationAffiliations: Hospital of Saint Raphael; New Haven, CT 06510 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByHepatotoxicity of Antimicrobials and Antifungal AgentsReversible oxacillin-associated hepatitis in a 9-month-old boyHepatotoxicity of antibiotics and antifungalsHigher Occurrence of Hepatotoxicity and Rash in Patients Treated with Oxacillin, Compared with Those Treated with Nafcillin and Other Commonly Used AntimicrobialsAntibiotic-Associated Hepatitis: Update from 1990Drug-Induced Hepatotoxicity 15 June 1994Volume 120, Issue 12Page: 1048KeywordsAlcoholismChronic hepatitisEndocarditisGlutathioneHIVHIV infectionsHepatitisHepatitis B surface antigenHepatitis virusesIntoxication Issue Published: 15 June 1994 CopyrightCopyright © 1994 by American College of Physicians. All Rights Reserved.PDF DownloadLoading ...