tbuckley/cabot-search huggingface dataset:
Myocardial mechanics for the early detection of cardiac sarcoidosis
Authors: John Felekos, Elias Gialafos, Vasileios Kouranos, Elias Perros, Anastasios Kallianos, Ouranis Anagnostopoulou, George Kaltsakas, Aggeliki Rapti, George Tzelepis, Konstantina Aggeli
Journal: European Respiratory Journal (2012)

Background: Speckle tracking has emerged as valuable tool for comprehensive assessment of regional myocardial function, providing angle-independent measurements of ventricular strain. Aim of this study was to evaluate left ventricular (LV) function in patients with newly diagnosed sarcoidosis, utilizing the novel method of 2D speckle tracking.  Methods: Forty one patients with sarcoidosis and unremarkable medical history of cardiovascular disease, as well as 20 healthy age- and gender-matched controls underwent echocardiographic study. Apical 4-,2-,3- chamber as well as short axis acquisitions were made. In addition to conventional 2D, Doppler and TDI measurements, speckle tracking echocardiography was applied and LV global longitudinal strain was derived from the obtained images. Moreover, LV base and apex rotation angles were assessed from which LV twist was derived.  Results: The mean age of patients (17 men) was 41 ± 6.5 years old. Compared with controls, patients had similar conventional 2D and Doppler measurements. TDI revealed increased E/E9 in the patient group vs control group (8.72 ± 1.65 vs 4.6 ± 1.32, p  Conclusions: Speckle tracking echocardiography revealed impaired strain and rotational indices, implying elevated filling pressures of the left ventricle. This may represent a sign of myocardial involvement in patients with sarcoidosis. Therefore deformation imaging could be valuable adjunct for screening.
Abstract P125: Baicalein Preconditioning Protects Murine Cardiomyocytes From Ischemia/reperfusion Injury via Mitochondrial Oxidant and Akt Signaling
Authors: Zuo-hui Shao, Jing Li, Willard W Sharp, Kimberly R Wojcik, Wei-Tien Chang, Chang-Qing Li, Mei Han, Chin-Wang Hsu, Kimm J Hamann, Terry L Vanden Hoek
Journal: Circulation (2009)

Introduction: Most cardioprotection studies with flavonoid compounds focus on their antioxidant properties. However, others have reported that flavoinoids such as baicalein, derived from the root o...
Paradoxical effects of amitriptyline on borderline patients
Authors: P H Soloff, A George, R S Nathan, P M Schulz, J M Perel
Journal: American Journal of Psychiatry (1986)

A paradoxical increase in suicide threats, paranoid ideation, and demanding and assaultive behavior occurred among 15 borderline inpatients receiving amitriptyline in a double-blind study. This pattern differed significantly from that of 14 nonresponding patients receiving placebo.
Congress Passes Mental Health Parity Bill
Authors: Bridget M Kuehn
Journal: JAMA (2008)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The misunderstood Spanish-speaking patient
Authors: Frank Kline, Frank X. Acosta, William Austin, Richard G. Johnson
Journal: American Journal of Psychiatry (1980)

The authors examined the reactions of Spanish-speaking patients and of therapists to initial therapy interviews conducted with or without an interpreter. Twenty-one patients who used an interpreter, 40 bilingual patients, and the 16 psychiatric residents who conducted the interviews completed questionnaires aimed at evaluating therapy and communication effectiveness. A number of patient and therapist perceptions were significantly different. Patients interviewed with interpreters felt understood and helped and wanted to return, whereas the therapists responded that patients seen with interpreters felt less understood and less helped and did not want to return. The authors recommend more bilingual/bicultural therapists and an effort to help present therapists realize how valuable their efforts with patients who need an interpreter are.
Abstract 11658: Three Dimensional Transesophageal Echocardiography in Transcatheter Aortic Valve Implantation - Comparison with 2D Data and Impact on Prosthesis Size Selection
Authors: Oliver Husser, Simon Rauch, Markus Resch, Dierk H Endemann, Julio Nunez, Vicent Bodi, Simon Schopka, Michael Hilker, Christof Schmid, Gunter A Riegger, Andreas Luchner, Christian Hengstenberg
Journal: Circulation (2011)

Objectives: To compare aortic annulus diameters obtained by 3D transesophageal echocardiography (TEE) with 2D-TEE and the impact on prosthesis size selection in transcatheter aortic valve implantation (TAVI) Background: In TAVI the aortic annulus diameter determines prosthesis size. The ideal modality for annulus assessment has not been defined yet. Methods: Annulus diameters in 2D-TEE (long-axis view) and in 3D-TEE (long-axis view in multiple-plane-reconstruction) were compared in consecutive patients with aortic stenosis screened for TAVI. Prosthesis size was selected according to industry guidelines, integrating data from 3D-TEE, angiography and computed tomography. The percentage of cases in which 2D-TEE and 3D-TEE correctly predicted final prosthesis size was calculated. Results: 49 patients were studied (Age 80±5, 39% male, logistic EuroScore 17±11%). Annulus diameters from 2D- and 3D-TEE correlated (r= .808, p<.0001). Mean diameters were significantly larger on 3D- vs. 2D-TEE (23.4±2.2 vs. 22.1±2.6...
Abstract 2049: Fluid Resuscitation with Na+/h+ Exchanger Inhibitor Improves Cardiovascular and Metabolic Function in a Pig Model of Uncontrolled Hemorrhagic Shock
Authors: Dongmei Wu, Hui Dai, Jiansong Qi, William Abraham
Journal: Circulation (2008)

Uncontrolled hemorrhage remains a leading cause of traumatic death. The aim of this study was to evaluate the effects of Na+/H+ exchanger (NHE) inhibition on enhancing fluid resuscitation outcomes in traumatic hemorrhagic shock, and to investigate the mechanisms related to NHE inhibitor -induced protection and recovery from hemorrhagic shock. Tibia fractures with soft tissue injury were induced in 12 anesthetized instrumented male pigs. The animals underwent hemorrhage of 25ml/kg for 20min, followed by a 4mm abdominal aortic tear with surgical repair after 30minutes. Animals then underwent initial fluid resuscitation with either 15ml/kg Hextend (n=6) or 3mg/kg BIIB513 +15ml/kg Hextend (n=6). Resuscitation occurred over 40 minutes. A second resuscitation was given 4 hours later. Studies were terminated at 6 hours. All animals survived the entire experiment. In both groups , hemorrhage resulted in similar impaired myocardial performance, and severe hemodynamic and metabolic alterations. Compared to resuscitation with Hextend alone, the addition of BIIB513, improved the hemodynamic response to fluid resuscitation showing a 23% increase in mean blood pressure and a 31% increase in blood oxygen content, as well as preventing metabolic acidosis during early resuscitation. Echocardiography analysis showed that NHE-1 inhibition with BIIB513 attenuated the hemorrhage induced myocardial hypercontracture and resulted in a significant 77% increase in stroke index. NHE-1 inhibition also reduced plasma levels of myocardial troponin-I by 88%, attenuated myeloperoxidase activity in the liver by 46%, and improved organ function. Consistent with this was the finding that nuclear factor (NF)-κB phosphorylation, nuclear translocation, and NF-κB DNA binding activity in the liver was attenuated in Hextend + BIIB513 treated animals, compared to Hextend only treated animals. The present study shows that the response to fluid resuscitation after traumatic hemorrhage is improved by the addition of the NHE-1 inhibitor BIIB513. That BIIB513 treatment attenuates NF-κB activation and neutrophil infiltration suggests that this improvement may be related to the reduction in tissue inflammatory injury. This research has received full or partial funding support from the American Heart Association, AHA National Center.
Abstract 879: The Chemokine CXCL10 Is Involved In The Development Of Atherosclerotic Plaque Vulnerability
Authors: Dolf Segers, Rini de Crom, Pieter Leenen, Gerard Pasterkamp, Rob Krams
Journal: Circulation (2007)

Introduction: Atherosclerosis is an inflammatory disease in which monocyte/macrophages and Th1 cells are crucial cell types. The CXC-chemokine CXCL10 might play a pivotal role in its pathogenesis as it mediates chemoattraction of these cells. We previously found that high CXCL10 levels in human carotid plaques are associated with a vulnerable phenotype. Moreover, we identified CXCL10 as a possible biomarker for vulnerability in a mouse model for vulnerable plaque. The aim of the current study was to evaluate if CXCL10 has a critical role in the development of plaque vulnerability. Methods: Atherosclerosis-susceptible female ApoE -/-mice on high fat, high cholesterol diet were instrumented with a perivascular shear stress-altering plastic cylinder to induce vulnerable plaque. In the first three weeks following surgery, mice were injected 3 times/week with a bioactivity-neutralizing CXCL10 antibody. After 9 weeks, plaques were harvested and sections were evaluated for macrophages (CD68), immune activation (MHC class II), smooth muscle cells (a-actin), lipids (Oil Red O) and collagen (picrosirius red). Results: Lesion sizes were equal in both the intervention group and the control group. Also lipid accumulation was comparable in both groups. Despite unaffected macrophage content (30.1 vs 28.7% p = 0.73), we did find a 2-fold reduction of MHC class-II expression (4.9 vs 14.5% p = 0.011) in the antibody-treated group. This decline in activation of the immune system coincided with an increase in the presence of smooth muscle cells (12.6 vs 4.2% p = 0.034) and an increase in collagen content (9.7 vs 21.8% p = 0.014). Conclusion: This study confirms a pivotal role of CXCL10 in the development of vulnerable plaque. Inhibiting CXCL10 resulted in an increase of plaque stability by decreasing immune activation and increasing smooth muscle cell and collagen content. Accordingly, CXCL10 is a potential marker for both diagnostic and therapeutic intervention.
Abstract 15012: The Predictive Values in Patients With Multivessel coronary artery disease; The SYNTAX Score, EuroSCORE and Global Risk Classification for the Risk Stratification
Authors: Jeong Yoon Jang, Duk-Woo Park, Yong-Giun Kim, Gyung-Min Park, Ki Won Hwang, Chang Hee Kwon, Suk-Won Choi, Hae-Geun Song, Jung-Min Ahn, Won-Jang Kim, Jong-Young Lee, Soo-Jin Kang, Seung-Whan Lee, Young-Hak Kim, Cheol Whan Lee, Seong-Wook Park, Seung-Jung Park
Journal: Circulation (2011)

Background: There is a renewed interest in combining clinical and angiographic information to predict risk of patients undergoing multivessel revascularization. The aim of this study was to investi...
Abstract 10952: Network Analysis Identifies the Orphan Receptor Tyrosine Kinase Ros1 as a Determinant of Glutathione Peroxidase-1 Mediated Vascular Remodeling
Authors: Ziad A Ali, Vinicio de Jesus Perez, Azad Raiesdana, Nicholas J Leeper, Stephan Pan, Xiumei Qu, Ayyaz Ali, Roxanna Haghighat, Kimihiko Kato, Keith M Channon, Marlene Rabinovitch, Thomas Quertermous, Euan A Ashley
Journal: Circulation (2011)

Ziad A Ali, 2011 Finalist and Presenting Author
SYNTHESIS OF TUMOR INHIBITION BY A TRYTOPHAN MUSTARD.
Authors: Ralph K. Barclay, Mildred A. Phillipps, Giulio C. Perri, Kanematsu Sugiura
Journal: Cancer Research (1964)

5-Bis(β-chloroethyl)amino-dl-tryptophan (“tryptophan mustard”) has been synthesized in improved yields and has been studied extensively for its anti-tumor effect in 32 solid tumors, two ascites tumors, and one virus leukemia. Tryptophan mustard had a complete inhibitory effect on both Ehrlich and Sarcoma 180 ascites tumors in the mouse, and on the Jensen sarcoma, Flexner-Jobling carcinoma, and Yoshida sarcoma in the rat. Its spectrum of activity is essentially the same as phenylalanine mustard (Melphalan). In comparison with nitrogen mustard (HN2), tryptophan mustard has a much wider therapeutic index.
Six different cytokines that share GP130 as a receptor subunit, induce serum amyloid A and potentiate the induction of interleukin-6 and the activation of the hypothalamus-pituitary-adrenal axis by interleukin-1
Authors: F Benigni, G Fantuzzi, S Sacco, M Sironi, P Pozzi, CA Dinarello, JD Sipe, V Poli, M Cappelletti, G Paonessa, D Pennica, N Panayotatos, P Ghezzi
Journal: Blood (1996)
Binding of Anticell Adhesive Oxime‐Crosslinked PEG Hydrogels to Cardiac Tissues
Authors: Gregory N. Grover, Julian Garcia, Mary M. Nguyen, Matthew Zanotelli, Michael M. Madani, Karen L. Christman
Journal: Advanced Healthcare Materials (2015)

Postsurgical cardiac adhesions increase the number of surgeries as well as patient mortality and morbidity. A fast gelling oxime-crosslinked PEG hydrogel with tunable gelation time, degradation, and mechanical properties is presented. This material is cytocompatible and prevents cellular adhesion. Material retention on different cardiac tissues is demonstrated ex vivo over time and that functional group ratio alters material retention on different cardiac tissues.
Bin1: a favorable prognostic marker and chemotherapeutic modulator in neuroblastoma
Authors: Xiaoling Zhong, Derek J. Hoelz, Hari Kumar, John A. Sandoval, Frederick J. Rescorla, Robert J. Hickey, Linda H. Malkas
Journal: Clinical Cancer Research (2008)

A35   Bin1 protein displays multiple functions such as suppression of oncogenic transformation and promoting apoptosis. Loss or reduction of Bin1 expression has been evident in many human cancers including breast, prostate, and neuroblastoma (NB), and correlated with the poor outcome of patients. NB originates from precursor cells of the peripheral nervous system and is the most common extracranial solid tumor in children. The tumor is metastatic in 70% of NB patients at the time of diagnosis and the overall prognosis is particularly poor despite aggressive therapies (10-40% survival in high-risk cases). Here we show that Bin1 is frequently reduced or lost in cell lines derived from the bone marrow metastasis or abdominal mass of NB patients. To establish the direct functional link between Bin1 expression and NB, we created NB cell lines that stably overexpress Bin1. Because Bin1 has a role in apoptosis and because survival of cancer cells in the systemic circulation plays a crucial role in the multistep metastatic process, we examined the role of Bin1 in cell survival under an anchorage disrupted condition. Forced Bin1 overexpression in the stable cells increased cell death when cultured in Poly-Hema coated plates. This type of cell death is believed to be a specialized apoptosis (anoikis) .  Additionally, many chemotherapeutic agents kill tumor cells via apoptosis, and we also evaluated the influence of Bin1 on chemosensitivity. The results showed that Bin1 overexpression enhances cell killing by Doxorubicin, a commonly used anticancer agent. Proteomic analyses of cell lysates from Bin1 transfectants  versus  the vector controls revealed differentially expressed proteins. This indicates that Bin1 may modify the metastatic behaviors and chemoresponsiveness  in NB  via regulating the expression levels of other cellular proteins. Our results establish Bin1 as an important factor for NB metastasis and chemosensitivity. Thus, loss of Bin1 could serve as a prognostic marker for metastatic potential and therapeutic response, and targeting Bin1 and Bin1-regulated pathways could be a rational strategy for the treatment of high-risk NB patients.
Comparison of teams is difficult
Authors: A. Morrison, C. Runcie
Journal: BMJ (1996)

EDITOR,—Joseph Britto and colleagues' study of a paediatric retrieval team1 closely mirrors a descriptive study performed by the specialist transport team based in our hospital's adult intensive care unit.2 We agree with Stuart Logan, who says in his commentary on Britto and colleagues' paper that randomised controlled trials comparing specialist with non-specialist transfer are problematic and that evaluation of the introduction of specialist retrieval teams by the use of scoring systems should provide firmer evidence of their …
Abstract 4188: Prognostic implications of Ischemic Myocardial Scar by Cardiac Magnetic Resonance in Patients with Normal Coronary Angiography and Dilated Cardiomyopathy
Authors: Alfonso Valle, Miguel Corbi, Mercedes Nadal, Jordi Estornell, Elena Lucas, Nieves Martinez, Juan Restrepo, Alesandro Pirola, Leandro Perez, Francisco Ridocci-Soriano
Journal: Circulation (2008)

Background . In patients (pts) with chronic heart failure, late gadolinium enhancement cardiovascular magnetic resonance (LGE-CMR) is capable to distinguish left ventricular systolic dysfunction (LVSD) related or not to coronary artery disease (CAD). Moreover about 10% of pts with dilated cardiomyopathy (DCM) are actually «unrecognized » ischemic cardiomyopathy (ICM), possibly because of coronary recanalization after silent infarction. However, the prognostic implications of « unrecognized » ICM are not known. Methods. Three hundred consecutive pts with heart failure and LVSD underwent LGE-CMR and were followed prospectively during 833 days (12–2724). The primary endpoint was the composite of cardiac death or heart failure hospitalization. Pts were classified into 4 groups : DCM without LGE (N 149) ; DCM with midwall fibrosis (n 35) ; ICM : ischemic scar and CAD (n 81) ; « unrecognized » ICM : ischemic scar without CAD (n 30). Results. 111 pts (38%) experienced events during follow-up.. There were non significant differences in event rate in patients with « unrecognized » ICM and ICM (53% and 63% respectively). By contrast the event rate in ICM groups were significantly higher than in pts with DCM (29% in group 1 and 31% in group 2 ; p = 0.000001) (Figure ). By multivariate analysis LGE was the strongest predictor of cardiac events (HR 1,7 CI 95% 1.07–2.88). Conclusions . In our series, pts with « unrecognized » ICM detected by CMR had a high risk of cardiac events during follow up similar to those pts with ICM. These findings had potentially important implications for routine use of CMR as a diagnostic and prognostic tool in patients with heart failure and systolic dysfunction.
Only 0.08% of funding for research in NHS goes to complementary medicine
Authors: E Ernst
Journal: BMJ (1996)

EDITOR,—In her thought provoking editorial on regulating complementary medicine Julie Stone is right to point out that a commitment to research is one precondition for complementary medicine to advance.1 The lack of rigorous research in complementary medicine is considerable.2 The reasons are probably diverse, but lack of funding …
Is maternal smoking during pregnancy a risk factor for attention deficit hyperactivity disorder in children?
Authors: S Milberger, J Biederman, S V Faraone, L Chen, J Jones
Journal: American Journal of Psychiatry (1996)

This study investigated the role of maternal smoking during pregnancy in the etiology of attention deficit hyperactivity disorder (ADHD).Subjects were 6-17-year-old boys with DSM-III-R ADHD (N = 140) and normal comparison subjects (N = 120) and their first-degree biological relatives. Information on maternal smoking was obtained from mothers in a standardized manner by raters who were blind to the proband's clinical status.Twenty-two percent of the ADHD children had a maternal history of smoking during pregnancy, compared with 8% of the normal subjects. This positive association remained significant after adjustment for socioeconomic status, parental IQ, and parental ADHD status. Significant differences in IQ were found between those children whose mothers smoked during pregnancy and those whose mothers did not smoke (mean IQ = 104.9, SD = 12.3, and mean = 115.4, SD = 12.2, respectively).These findings suggest that maternal smoking during pregnancy is a risk factor for ADHD. If confirmed, these findings will stress the importance of programs aimed at smoking prevention in nonsmoking women and smoking cessation in smoking women of childbearing age.
Abstract 14535: Elevated Levels of D-Dimer Predict Adverse Outcomes in Patients With Nonvalvular Atrial Fibrillation at Low-Intermediate Risk
Authors: Keiko Nakagawa, Tadakazu Hirai, Kazumasa Ohara, Nobuyuki Fukuda, Satoshi Numa, Shutaro Takashima, Takashi Nozawa, Kortaro Tanaka, Hiroshi Inoue
Journal: Circulation (2011)

Background: In patients with atrial fibrillation (AF), there is no clear consensus about risk prediction or antithrombotic treatment at low-intermediate risk stratified by clinical variables. Eleva...
Abstract 13758: Tie2, Angiogenin, and Vegf in a Cohort of Patient With Stable Peripheral Artery Disease and Varying Glucose Metabolism
Authors: Clemens Hoebaus, Johanna M Brix, Gerfried Pesau, Wressnegger Alexander, Eva C Krzizek, Renate Koppensteiner, Guntram Schernthaner, Gerit Schernthaner
Journal: Circulation (2013)

Objective: Recently, stem cell growth factors have gained attention in patients suffering from complications of diabetes. In this study we investigated the angiogenetic proteins: angiogenin (ANG), ...
Cloning, characterization, and functional studies of human and mouse glycoprotein VI: a platelet-specific collagen receptor from the immunoglobulin superfamily
Authors: Martine Jandrot-Perrus, Samantha Busfield, Anne-Helène Lagrue, Ximing Xiong, Najet Debili, Troy Chickering, Jean-Pierre Le Couedic, Andrew Goodearl, Barry Dussault, Christopher Fraser, William Vainchenker, Jean-Luc Villeval
Journal: Blood (2000)
Endothelial-Specific Knockdown Of Caveolin-1 Lowers Circulating Protein Disulfide Isomerase Levels and Is Associated With Changes In Erythrocyte Volume Homeostasis
Authors: Josue A. Benabe-Carlo, Jose R Romero, Enrique D. Machado-Fiallo, Arelys Ramos-Rivera, Gregory N. Prado, Luminita H Pojoga, Alicia Rivera
Journal: Blood (2013)
Immunoglobulin levels and severity of community-acquired pneumonia (CAP)
Authors: Jordi Almirall, Mari De la Torre, Elisabet Palomera, Montserrat Bartrolí, Joan Carles Yébenes, Pere Torán, Mateu Serra-Prat, Antoni Torres
Journal: European Respiratory Journal (2014)

We have prospectively selected 418 patients with CAP who were treated in Health Care Centres (HCC)(mild), and hospitalized in wards (moderate) or in intensive care units (ICU) (severe) from 2001 to 2012.  All of them were tested Ig serum levels using the nefelometry technique on the first day after being diagnosed with CAP. After that we compared results among the three different CAP severities (Table 1) and the frequency of mortality (Table 2).  Conclusions:  1.- In severe CAP patients Ig levels (IgG1, IgG2, IgG3, IgG4, IgA and IgM) decrease.  2.- Having a decreased level in IgG total, IgG1, and IgG2 during a pneumonia process, is related to higher mortality.