tbuckley/cabot-search huggingface dataset:
IgE‐mediated hypersensitivity reactions to methylprednisolone
Authors: A. Aranda, C. Mayorga, A. Ariza, I. Doña, N. Blanca‐Lopez, G. Canto, M. Blanca, M. J. Torres
Journal: Allergy (2010)

To cite this article: Aranda A, Mayorga C, Ariza A, Doña I, Blanca‐Lopez N, Canto G, Blanca M, Torres MJ. IgE‐mediated hypersensitivity reactions to methylprednisolone. Allergy 2010; 65 : 1376–1380. Abstract Background: Allergic reactions to systemically administered corticosteroids seem to be infrequent considering their extensive use. The aim of the study was to evaluate the IgE response in patients with immediate allergic reactions to methylprednisolone (MP). Methods: Four subjects who developed immediate reactions after MP administration and ten controls with good tolerance to MP administration were evaluated. Skin prick and intradermal testing were done using MP, hydrocortisone (HC), and dexamethasone (DX). If negative, a drug provocation test (DPT) was done to confirm the diagnosis and assess cross‐reactivity. The in vitro IgE response was evaluated by the basophil activation test (BAT) and ImmunoCAP. Results: Three patients were diagnosed by the presence of a positive skin test in the immediate reading with MP, two by prick and one by intradermal testing, and one patient was skin test negative and diagnosed by DPT. All four patients had good tolerance to HC and DX. The BAT was positive for just MP in those patients with positive skin tests, with all patients being negative for HC and DX. Two patients were also ImmunoCAP positive to MP. Conclusions: This study confirms the existence of immediate allergic reactions to MP and that some are mediated by specific IgE antibodies. Skin testing, ImmunoCAP and the BAT are useful to confirm the diagnosis.
Book: Medicine in the English Middle Ages
Authors: C. Lawrence
Journal: BMJ (1999)

Faye Getz Princeton University Press, £21.95, pp 174 ISBN 0691085226 Rating: ![Graphic][1]</img>![Graphic][2]</img>![Graphic][3]</img> The term medieval, although available for simple descriptive use, is also open to pejorative employment. How would you like your values, way of life, or indeed your medical practice described as medieval? Such a use is an inheritance of the stigmatisation of the middle ages as superstitious and priest-ridden by our rationalist grandparents, notably Edward Gibbon. Outside this tradition, however, has been another that has sought to understand medieval art and religion in its own … [1]: /embed/inline-graphic-1.gif [2]: /embed/inline-graphic-2.gif [3]: /embed/inline-graphic-3.gif
Study strengthens link between BSE and vCJD
Authors: Scott Gottlieb
Journal: BMJ (2000)

A new study has produced compelling evidence that the same infectious protein that causes mad cow disease is also responsible for causing variant Creutzfeldt-Jakob disease (vCJD). The number of deaths from the disease in Europe has now reached 51.

The lead author, Dr Michael Scott, and colleagues at the Institute for Neurodegenerative Diseases at the University of California, San Francisco, and Dr Robert Will and colleagues at the National CJD Surveillance Unit at the Western General Hospital in Edinburgh, found that bovine spongiform encephalopathy (BSE) and its human form, vCJD, are likely to be caused by the same infectious agent ( Proceedings of the National Academy of Sciences 1999;96:15137-42).

In the study the researchers created a strain of mice that had …
Alcoholism in Peru
Authors: J Yamamoto, J A Silva, T Sasao, C Wang, L Nguyen
Journal: American Journal of Psychiatry (1993)

Alcoholism is a problem of worldwide concern. Full appreciation of this international problem requires that adequate diagnostic measures be constructed and that comparable measures for different cultures be available so that valid differences in prevalence across cultures can be detected. A Spanish-language version of the Diagnostic Interview Schedule (DIS) has been used for epidemiologic studies of alcohol abuse and dependence in Los Angeles Mexican-Americans and mainland Puerto Ricans, and the authors used the same instrument to conduct a similar study in Peru.A population sample (N = 815) from the Independencia district of Lima, Peru, was chosen for interviews with a revised form of the Spanish translation of the DIS. Lifetime prevalence rates of alcoholism and other DSM-III diagnoses were determined.The prevalence of alcohol abuse or dependence was higher among the men (34.80%) than among the women (2.46%), but the onset for women was earlier. Alcoholism was strongly associated with antisocial personality disorder and with drug abuse or dependence.The prevalence of alcoholism for the Peruvian men is higher than prevalences for men in U.S. studies, but the prevalence among the Peruvian women is one of the lowest reported. The high prevalence among men is likely due to cultural mores but may also be linked to the stresses found in impoverished societies undergoing rapid social, cultural, and economic change.
Abstract 17732: Identification of Stromal Interaction Molecule 1 Complexes in Cardiac Hypertrophy
Authors: Ahyoung Lee, Changwon Kho, Ludovic Bénard, Antoine Chaanine, Roger Hajjar, Jean-Sébastien Hulot
Journal: Circulation (2014)

Abnormalities in intracellular calcium signaling initiate and promote sustained pathological cardiac hypertrophy. Stromal interaction molecule 1 (STIM1) is an essential calcium sensor that activates calcium influx in response to calcium depletion in the endoplasmic reticulum (ER) in many cells. Previously, we found that STIM1 is activated and functional in hypertrophic cardiomyocytes where it controls store-dependent and -independent calcium influxes that further promote the development of cardiac hypertrophy. To understand the regulatory mechanisms of STIM1 during hypertrophic remodeling, we performed interactome analyses on a rat model of compensated cardiac hypertrophy resulting from pressure overload by thoracic aortic banding. STIM1 complexes were immunoprecipitated from cardiomyocytes isolated from either control or aortic-banded hearts. Electrospray ionization tandem mass spectrometry analysis identified a total of 93 proteins that were reliably enriched in the STIM1 immunoprecipitates in multiple independent experiments. Silver staining of the isolated complexes revealed distinct patterns of associated proteins in the disease states. STIM1 complexes were enriched in hypertrophic hearts with a total of 78 identified proteins as compared to 53 proteins in control hearts. Only 38 proteins were associated with STIM1 in both control and diseased conditions. Next, we performed a functional classification of our interactome data. Gene Ontology (GO) analysis showed distinct functional GO categories including ion channels, cellular signaling molecules, apoptosis, ER function and mitochondrial function. We finally mapped the identified proteins using the STRING interaction database that further revealed functional relationships between the STIM1 complex proteins and significant changes during hypertrophic remodeling. These findings identify multiple specific functional complexes for STIM1 that are recruited during cardiac hypertrophy. These data support a model where STIM1 is a dynamic signal transducer that can interact with a diversity of proteins depending on the pathophysiological conditions.
Managing Heart Failure in Primary Care, by Henry Dargie
Authors: P. J Herbert
Journal: BMJ (1997)

Henry Dargie / Blackwell Scientific, £19.95, pp 256 / ISBN 0 86542 966 9

What does a primary care doctor need to know about heart failure, now that there are established ways of reducing its morbidity and mortality? Heart failure in all its forms affects 1-2% of the populations of Europe and North America, and it represents an escalating healthcare problem in these countries, accounting for between 1% and 2% of the total healthcare spending in Europe …
Abstract 12935: Hypocaloric Diet and Exercise Training Improves the Chemoreflex Sensitivity in Patients with Metabolic Syndrome and Obstructive Sleep Apnea
Authors: Cristiane Maki-Nunes, Edgar Toschi-Dias, Felipe X Cepêda-Fonseca, Maria U Rondon, Maria J Alves, Luciano F Drager, Adriana M Aguilar, Virend K Sommers, Geraldo Lorenzi-Filho, Carlos E Negrão, Ivani C Trombetta
Journal: Circulation (2011)

Cristiane Maki-Nunes, 2011 Finalist and Presenting Author
Prediction of Pulmonary Complications and Long‐Term Survival in Systemic Sclerosis
Authors: Svetlana I. Nihtyanova, Benjamin E. Schreiber, Voon H. Ong, Daniel Rosenberg, Pia Moinzadeh, J. Gerrard Coghlan, Athol U. Wells, Christopher P. Denton
Journal: Arthritis & Rheumatology (2014)

Objective To assess survival and incidence of organ‐based complications in a large single‐center cohort of unselected systemic sclerosis (SSc) patients, and to explore predictors of survival and clinically significant pulmonary fibrosis (PF) and pulmonary hypertension (PH). Methods The study cohort consisted of 398 consecutive SSc patients, followed up for up to 15 years. Cox proportional hazards analysis with demographic, clinical, and laboratory characteristics as predictor variables was used to develop prediction models for pulmonary complications and survival. Results The overall survival estimate at the end of followup was 57% among patients with limited cutaneous SSc (lcSSc) and 50% among patients with diffuse cutaneous SSc (dcSSc) ( P = 0.017). We found that greater age at disease onset, dcSSc, lower diffusing capacity for carbon monoxide (DL co ), lower hemoglobin levels, higher serum creatinine levels, and the presence of PH or cardiac involvement were independent predictors of worse survival. Over the entire followup period, 42% of dcSSc patients and 22% of lcSSc patients developed clinically significant PF ( P &lt; 0.001). The variables that predicted clinically significant PF development were dcSSc, greater age at onset, lower forced vital capacity and DL co , and the presence of anti–topoisomerase I antibody, while the presence of anticentromere antibody was protective. There was no difference in cumulative incidence of PH between the 2 subsets—24% in lcSSc and 18% in dcSSc ( P = 0.558). Incidence rates were 1–2% per year. The PH prediction model demonstrated that greater age at onset, increase in serum creatinine levels, lower DL co , and the presence of anti–RNA polymerase III or anti–U3 RNP antibodies were associated with increased risk of PH, while anti–topoisomerase I antibody positivity reduced the hazard. Conclusion Our study provides data on long‐term outcome of SSc and the timing and frequency of major organ complications. The predictive models we present could be used as clinical tools for patient risk stratification and could facilitate cohort enrichment for event‐driven studies.
Tumor Markers for Hepatocellular Carcinoma: Simple and Significant Predictors of Outcome in Patients with HCC
Authors: Hidenori Toyoda, Takashi Kumada, Toshifumi Tada, Yasuhiro Sone, Yuji Kaneoka, Atsuyuki Maeda
Journal: Liver Cancer (2015)

&lt;b&gt;&lt;i&gt;Background: &lt;/i&gt;&lt;/b&gt;The effectiveness of tumor markers in evaluating outcomes of patients with hepatocellular carcinoma (HCC) remains to be clarified. &lt;b&gt;&lt;i&gt;Summary: &lt;/i&gt;&lt;/b&gt;The usefulness of the HCC tumor markers, alpha-fetoprotein (AFP), &lt;i&gt;Lens culinaris&lt;/i&gt; agglutinin-reactive fraction of alpha-fetoprotein (AFP-L3), and des-gamma-carboxy prothrombin (DCP) was reviewed. Elevations in these tumor markers at the time of HCC diagnosis correlate with disease progression as assessed by both imaging studies and pathologic examinations. The combination of these three tumor markers results in good predictive ability for patient survival after diagnosis. In addition, combination at the time of HCC diagnosis of these three tumor markers (as a measure of tumor progression) and serum albumin and bilirubin levels (as indicators of remnant liver function) can be used for HCC staging and further predicts prognosis in patients with HCC. &lt;b&gt;&lt;i&gt;Key Message: &lt;/i&gt;&lt;/b&gt;The prognosis of patients with HCC can be well discriminated based solely on serum markers. Staging of HCC with serum markers is objective; if stored serum samples are available, HCC stages can be standardized across different countries and time periods.
Perceptions of Physician Shortages
Authors: Richard A. Cooper, Steven A. Wartman
Journal: JAMA (2004)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
A Case With Apical Hypertrophic Cardiomyopathy, Multiple Coronary Artery–Left Ventricular Fistulae, and a Morphological Structure Mimicking Left Ventricular Noncompaction
Authors: Sakura Nagumo, Mio Ebato, Masaaki Kurata, Kohei Wakabayashi, Hisa Shimojima, Tokutada Sato, Yoshiro Hori, Hiroshi Suzuki
Journal: Circulation (2015)
439. Neuronal Membrane Specific Binding Peptides Isolated Via Phage Display Biopanning Against Trisialogangliosides
Authors: James K. Liu, Qingshan Teng, Diana Tanase, Mary Moses, Ajit Krishnaney, Nicholas M. Boulis
Journal: Molecular Therapy (2004)

Background: The tropism of adeno-associated viral vectors can be altered by inserting peptides into the vector's coat. However, large peptides may alter the capacity of VP proteins to package DNA. In order to enhance the neural affinity and specificity of AAV binding, we have attempted to isolate short peptides which when inserted into the cap gene of the AAV genome, would retarget the vector toward neuronal membranes without hindering its transduction efficiency. We have previously reported a phage display biopanning strategy for the isolation of such peptides (Liu et al Mol Ther: 7(5) S351, 2003). We used trisialogangliosides (GT1b), a known receptor of Clostridial tetanus toxin present on neuronal membranes, as our target. Tetanus toxin owes its high neuronal affinity to specific GT1b binding providing an ideal interaction to replicate in AAV. Using a random 12 amino acid peptide phage library, we conducted a novel four round biopanning process against immobilized GT1b. In the final three rounds of biopanning, we eluted with recombinant Tetanus Toxin C Fragment (rTTC) to recover phage that specifically mimic its binding to GT1b. Four candidate peptides were enriched following the biopanning process. We selected the most common peptide (Clone 2A) which was present in 70% of the sequenced phage clones along with a second peptide (Clone 2B) that shared similar homology with Clone 2A (Liu et al Mol Ther: 7(5) S351, 2003).
The International Normalized Ratio (INR) for Monitoring Warfarin Therapy: Reliability and Relation to Other Monitoring Methods
Authors: Dzung The Le
Journal: Annals of Internal Medicine (1994)

Objective: To enhance understanding of the reliability of the international normalized ratio (INR) for monitoring warfarin therapy and its relation to other monitoring techniques. Design: Prospective cohort study. Setting: A university hospital. Patients: 79 patients attending an anticoagulation clinic. Measurements: International normalized ratios obtained with a portable capillary monitor (Coumatrak) and the following from a simultaneous plasma sample: INRs from prothrombin times done with six thromboplastins, prothrombin-proconvertin (P&P) test activity, specific prothrombin activity, and native prothrombin antigen. Results: Converting to INRs failed to standardize prothrombin time results obtained with high- and low-sensitivity thromboplastins. Coumatrak INRs correlated best with INRs obtained with high-sensitivity thromboplastins. The INR range of 2.0 to 3.0 corresponded to a P&P range of 30% to 13%, a native plasma prothrombin antigen range of 56 to 24 µg/mL, and a specific prothrombin activity range of 43% to 21%. Conclusions: Low-sensitivity thromboplastins may give erroneously high INRs in the upper therapeutic range. Plasma prothrombin times should be done with a high-sensitivity thromboplastin, particularly in patients maintained at the upper limit of the therapeutic range. An INR so obtained correlated well with an INR obtained with a portable capillary blood monitor.
NHS in England ends financial year £200m in debt
Authors: Wendy Moore
Journal: BMJ (2000)

Nearly a third of the extra £600m ($960m) already released to the NHS in the UK from the £2bn boost announced in last month's Budget could be wiped out by accumulated debt, a report from the National Audit Office makes clear.

The NHS Confederation, which represents health authorities and trusts, is “optimistic” that the NHS will be allowed to write off England's £197m deficit with the first tranche of new money, even though the health secretary, Alan Milburn, has said that much of it will be earmarked for specific purposes. A …
AT‐Rich–Interactive Domain–Containing Protein 5A Functions as a Negative Regulator of Retinoic Acid Receptor–Related Orphan Nuclear Receptor γt–Induced Th17 Cell Differentiation
Authors: Yukari Saito, Shin‐Ichiro Kagami, Yoshie Sanayama, Kei Ikeda, Akira Suto, Daisuke Kashiwakuma, Shunsuke Furuta, Itsuo Iwamoto, Ken Nonaka, Osamu Ohara, Hiroshi Nakajima
Journal: Arthritis & Rheumatology (2013)

Objective The proinflammatory cytokines tumor necrosis factor α and interleukin‐6 (IL‐6) and the Th17 cell cytokine IL‐17A are implicated in the pathogenesis of rheumatoid arthritis (RA), and the blockade of these cytokines by biologic agents provides clinical benefits for RA patients. We undertook this study to clarify the mechanisms underlying the efficacy of IL‐6 blockade in RA and to find a novel target for treatment of RA. Methods We examined gene expression profiles of CD4+ T cells by DNA microarray analysis before and after treatment with an anti–IL‐6 receptor antibody, tocilizumab (TCZ), in RA patients who exhibited good clinical responses to the treatment. Using murine CD4+ T cells, we then examined the roles of a newly identified molecule whose expression was significantly reduced in CD4+ T cells by TCZ therapy. We also examined the effect of the forced expression of the molecule on retinoic acid receptor–related orphan nuclear receptor γt (RORγt)–induced IL‐17A production in CD4+ T cells and on RORγt‐induced IL‐17A promoter activation. Results We identified AT‐rich–interactive domain– containing protein 5A (ARID‐5A) as a new molecule down‐regulated by IL‐6 blockade in the form of TCZ therapy. IL‐6 induced the expression of ARID‐5A in CD4+ T cells during Th17 cell differentiation by a STAT‐3–dependent mechanism, whereas IL‐6–induced ARID‐5A expression was not affected by the absence of RORγt, a lineage‐specifying transcription factor of Th17 cells. Furthermore, ARID‐5A physically associated with RORγt through its N‐terminal region and inhibited RORγt‐induced Th17 cell differentiation. Conclusion ARID‐5A is a lineage‐specific attenuator of Th17 cell differentiation and may be involved in the pathogenesis of RA.
Phenotypic differences between asymptomatic airway hyperresponsiveness and remission of asthma
Authors: Takahiro Yoshikawa, Hiroshi Kanazawa, Kazuto Hirata
Journal: European Respiratory Journal (2011)

Background:  The present study aimed to illustrate differences in characteristics and perception of dyspnea between young atopic adults who have no history of asthma ( never -asthmatics) with or without asymptomatic airway hyperresponsiveness (AHR) and those who had childhood asthma and consider themselves to be grown out of the disease ( past -asthmatics).   Methods:  Blood parameters, lung function and methacholine PC 20  were measured in 88  never -asthmatics and 24  past -asthmatics. A perception score of dyspnea at 20% fall in FEV 1  (PS 20 ) was obtained by interpolation of the two last points on the perception (modified Borg scale)/fall in FEV 1  curve during methacholine challenge.   Results:  Thirty-one of 88  never -asthmatics and eighteen of 24  past -asthmatics exhibited AHR (PC 20  was  past -asthmatics were observed than  never -asthmatics with and without AHR. Mean values of FEV 1  and FEF 25-75  (%predicted) were significantly lower in  past -asthmatics than  never -asthmatics without AHR, and the values in  never -asthmatics with AHR were intermediate between  never -asthmatics without AHR and  past -asthmatics. PC 20  were not significantly different between  past -asthmatics and  never -asthmatics with AHR. Of particular interest was that PS 20  was significantly lower in  never -asthmatics with AHR compared with  past -asthmatics.   Conclusion:  The present findings suggest the possibilities that presence or absence of past history of outgrow of childhood asthma might be associated with airway narrowing, sensitization to house-dust mite and perception of dyspnea in young asymptomatic adults with atopy and AHR.
Infectious Agents and Host Reactions.
Authors: Stuart Mudd
Journal: Annals of Internal Medicine (1970)

dermal administration of typhoid and influenza vaccine paiticularly because their patielnts are allergic, in order to avoid severe reactions.Dr. Criep's view of this pro- cedure would be valuable.Incidentally, even the pack- age insest in typhoid vaccine lists this type of adin- istration as an alternative to the author's dose schedule.Special credit should be given for the unusually com- plete and accurate index.Most readers, I am sure, are thwarted by a poorly prepared index, but few know what a difficult and painstaking task preparing a good index is.Ideallv, the author should do it himself but usually it takes too much time.Most publishing firms have their own specialized indexers; some are good while many are very bad.I do not know how Dr. Criep's index was pre- pared but it certainly deserves commendation.
Schizophrenia Researchers Striving for Early Detection and Intervention
Authors: J Stephenson
Journal: JAMA (1999)

SANTA FE, NM—Can early treatment, preferably begun even before psychotic symptoms emerge, improve long-term outcomes for people with schizophrenia? That hope, according to researchers presenting new findings last month at the International Congress on Schizophrenia, is sparking efforts to identify early signs of the disease in high-risk individuals and to develop interventions aimed at delaying its onset or reducing its severity.