tbuckley/cabot-search huggingface dataset:
Cardiac Prognosis in Noncardiac Geriatric Surgery
Authors: Myron C. Gerson, James M. Hurst, Vicki S. Hertzberg, Patricia A. Doogan, Mary B. Cochran, Shun P. Lim, Nancy McCALL, Robert J. Adolph
Journal: Annals of Internal Medicine (1985)

Predictors of perioperative complications, including cardiac death, ventricular tachycardia or fibrillation, and heart failure or myocardial infarction, were assessed in an initial study of 100 patients aged 65 years or older scheduled for elective abdominal or noncardiac thoracic surgery. Preoperative history, results of physical examination, chest roentgenogram, electrocardiogram, laboratory data, Dripps (American Society of Anesthesiologists) class, and Goldman cardiac risk index were compared with rest and exercise radionuclide ventriculograms. Thirteen patients had perioperative cardiac complications, and 6 died. Multivariate analysis showed that an inability to do 2 minutes of bicycle exercise in the supine position to raise the heart rate above 99 beats/min (sensitivity 85%, specificity 64%) gave predictive information not available from clinical or radionuclide data. On prospective testing involving 55 additional geriatric patients, inability to exercise was the only independent predictor of perioperative complications (p less than 0.05). Data from rest and exercise radionuclide ventriculography added little information for predicting perioperative cardiac risk.
Latent Thematic Concordancy in Psychotherapy Sessions
Authors: R. Knebusch, H. Kordy
Journal: Psychotherapy and Psychosomatics (1985)

In a single case study of a psychoanalytically oriented treatment, the associative distance between patient and therapist concerning the subject of the session was rated. This distance was operationalized by the so-called 'latent thematic concordancy' (LCON) and measured after each session. With the aid of a modified form of the 'therapy session check sheet' (TSCS) of Graff and Luborsky, a constellation of low manifest and low positive transference together with high resistance was isolated which was linked with low LCON with a high prediction rate. This transference constellation resembles the resistance against transference as described by Gill. It seems to be related to a great distance between the associations of patient and therapist concerning the subject of therapy sessions.
Topical ONYX-015 in the Treatment of Premalignant Oral Dysplasia: Another Role for the Cold Virus?
Authors: Ian Ganly, Bhuvanesh Singh
Journal: Journal of Clinical Oncology (2003)

Article Tools EDITORIALS Article Tools OPTIONS & TOOLS Export Citation Track Citation Add To Favorites Rights & Permissions COMPANION ARTICLES No companion articles ARTICLE CITATION DOI: 10.1200/JCO.2003.08.997 Journal of Clinical Oncology - published online before print September 21, 2016 PMID: 14597746 Topical ONYX-015 in the Treatment of Premalignant Oral Dysplasia: Another Role for the Cold Virus? Ian GanlyxIan GanlySearch for articles by this author , Bhuvanesh SinghxBhuvanesh SinghSearch for articles by this author Show More Laboratory of Epithelial Cancer Biology, Memorial Sloan-Kettering Cancer Center, New York, NY https://doi.org/10.1200/JCO.2003.08.997 First Page Full Text PDF Figures and Tables © 2003 by American Society of Clinical Oncology
Academic medicine: time for reinvention: Teams are crucial for future clinical research
Authors: W. Caan
Journal: BMJ (2004)

Editor—Bell has done a great service in raising the urgency with which a strategic rethink of clinical research is needed.1 It is three years since very similar recommendations were published by Peckham's Foresight panel, including, for example, a national strategy for clinical trials,2 but rather than showing progress, during these years health science for practice has deteriorated further.​further.




Figure 1



Credit: GEOFF TOMPKINSON/SPL




Efforts by the NHS, research councils, and health charities to plan together strategically have been undermined by a rogue stakeholder, the Higher Education Funding Council for England, which has been determined to do its own thing. As the council puts it, in its latest review, there is no similar mechanism for encouraging collaboration between higher education institutions and research organisations outside the health education sector—that is, in health care.3 Whereas the NHS makes a massive contribution to teaching and learning for higher education, the Higher Education Funding Council for England simply will not consider the diverse development needs of teaching hospitals and primary care trusts.

If homegrown research is to thrive, we cannot “afford to look back nostalgically” to past roles.4 Published clinical research is overwhelmingly produced by teams, and clinical teams include nurses and allied health professionals who should contribute as partners (not handmaidens) to innovative research. Even more crucially, for the future of clinical research, patients should influence and be seen to influence research funding and the uptake of research findings. Good preliminary work has recently been shown here by Involve (www.invo.org.uk).
THE NEED OF AMALGAMATION OR FEDERATION OF POOR LAW OFFICERS AND ALLIED ASSOCIATIONS WITH THE BRITISH MEDICAL ASSOCIATION
Authors: J. Brown
Journal: BMJ (1909)

<h3>Summary</h3> Individuals with autism spectrum disorders (ASD) exhibit an increased burden of <i>de novo</i> variants in a broadening range of genes. We functionally tested the effects of ASD missense variants using <i>Drosophila</i> through ‘humanization’ rescue and overexpression-based strategies. We studied 79 ASD variants in 74 genes identified in the Simons Simplex Collection and found 38% of them caused functional alterations. Moreover, we identified <i>GLRA2</i> as the cause of a spectrum of neurodevelopmental phenotypes beyond ASD in eight previously undiagnosed subjects. Functional characterization of variants in ASD candidate genes point to conserved neurobiological mechanisms and facilitates gene discovery for rare neurodevelopmental diseases.
Case 27-2002: Late-Onset Infantile Neuronal Ceroid Lipofuscinosis
Authors: Kim L. McBride
Journal: New England Journal of Medicine (2003)

To the Editor: Rust and Karluk (Aug. 29 issue)1 discuss the case of a child with a neurodegenerative disorder who was found to have curvilinear lysosomal inclusion bodies on electron-micrographic a...
Imaging for Sinusitis
Authors: Duncan B. Howe
Journal: JAMA (1993)

<h3>To the Editor.</h3> —Dr Mafee<sup>1</sup>responded to a question concerning imaging methods for sinusitis. Mafee's response implied that a CT scan should be the radiologic examination of choice for chronic sinusitis. Our concern arises from the article's perfunctory treatment of the cost differential between CT and conventional radiography, the suggestion that benefit and information content are equivalent, and the absence of a comparison of the radiation doses received from the two imaging methods. The comment "the cost to the patient is somewhat more than for a complete sinus series; however, the difference in cost is well worth the expense because of the amount of information obtained from the screening sinus CT scan" is not a sufficiently thorough analysis of the situation. Sometimes additional information may be obtained from CT evaluation of the paranasal sinuses, but additional information does not invariably have a positive impact on the outcome of the
TRICHOMONAS VAGINITIS IN CHILDREN
Authors: LESTER E. FRANKENTHAL
Journal: JAMA (1933)

literature concerning Trichomonas vaginalis and its association with a definite syndrome of leukorrhea and vaginitis has become quite voluminous during the past decade. This type of vaginitis in recent years is frequently found in adults, both in private and in clinic patients. Whether this increase is actual or relative remains to be determined. Undoubtedly one is more alert in studying the vaginal secretions for these protozoa whenever their presence is suspected. Bland and his associates 1 have thoroughly reviewed the literature concerning Trichomonas in women. However, our own scrutiny of the literature has shown this type of vaginitis to be very rare in children. We have been unable to find a report detailing any author's personal experience with trichomonas vaginitis in children. In fact, Kleegman 2 in 1930 makes the following assertion: The organism has never been found before the onset of menstruation, but is frequently found during pregnancy
Smoking and Africa: the coming epidemic.
Authors: A Taha, K Ball
Journal: BMJ (1980)

of overt safeguards (in England) for the parents at the crux of the action, especially the dull and mentally handicapped.We believe that arrangements for reporting care actions in under-5s should be changed, separating out all instances of statutory removal of the newborn and children in their first three months of life.This would allow more detailed scrutiny of very early care actions and maternal abandonment for research and would enable better evaluation of a practice that has emerged tentatively over the past ten years.It would also provide more answers to questions about the drastic use of statutory powers and would, we believe, place the procedure in the context of all child care.proceedings.We believe that removal at birth is occasionally necessary and appropriate, but that more information is needed before proper criteria can be recognised and agreed.We had, for instance, wrongly assumed that psychotic illness or severe mental handicap only would justify removal of first-born children.Care will be needed in avoiding some extremes of intervention in the perinatal period, when all that may be required is to hold the mother and baby together while further inquiries and assessment are set in motion, as advocated recently by Dr Christina Cooper.'4Donald Bross, in a paper presented at the 2nd International Congress on Child Abuse and Neglect in 1978, suggested ways in which various US State laws might be used to bring about some control over a woman in late pregnancy and at childbirth.In Britain wardship might be tried13 to treat mother and baby as one entity, a particularly relevant possibility as more mother-and-child residential assessment units are developed.
Lumbar Puncture and Brain Tumor
Authors: Lester J. Wallman
Journal: JAMA (1967)

<h3>To the Editor:—</h3> In his recent review of the lumbar puncture (<b>201</b>:317, 1967), Dr. Eben Alexander, Jr., is characteristically gentle in pointing out its hazards in the presence of increased intracranial pressure. He might have gone further to show that with the development of other diagnostic tools the indications for lumbar puncture have diminished to the point where it is almost obsolete in the diagnosis of intracranial mass lesions. The lumbar puncture has secured a firm foothold in the folkways of medicine as a screening test to be performed whenever there is apparent malfunction of the nervous system. In many instances, the test is not considered complete unless the effect of jugular compression also is tried. However, I think most neurosurgeons will agree that the care of a patient harboring structural disease of the nervous system is often hampered or at least delayed by indiscriminate invasion of the subarachnoid
A third way
Authors: Gwyn Bevan
Journal: BMJ (2006)

The question of NHS independence is being raised because of the belief that it has been damaged by a series of reorganisations and dramatic shifts in policies. The Department of Health has been reorganised three times; the regional structure and purchasing tier in the NHS have each been reorganised four times; there have been mergers of providers of acute services and reorganisation of mental health services; and inspectorates have been created, expanded, abolished, and merged (with one lasting 17 days).1–5 The policy of a market driven by provider competition in which money followed the patient was introduced in 1991,6 abolished in 1997,1 and reintroduced from 2006, …
Lower-Extremity Edema Associated with Gene Transfer of Naked DNA Encoding Vascular Endothelial Growth Factor
Authors: Iris Baumgartner, Guenter Rauh, Ann Pieczek, Debra Wuensch, Meredith Magner, Marianne Kearney, Robert Schainfeld, Jeffrey M. Isner
Journal: Annals of Internal Medicine (2000)

Background: Vascular endothelial growth factor (VEGF) promotes angiogenesis and vascular permeability. The extent to which VEGF may cause tissue edema in humans has not been established. Objective: To evaluate patients undergoing VEGF gene transfer for evidence of lower-extremity edema. Design: Prospective consecutive case series. Setting: Hospital outpatient clinic. Patients: 62 patients with critical limb ischemia and 28 patients with claudication. Intervention: Gene transfer of VEGF DNA. Measurements: Semiquantitative analysis of lower-extremity edema. Results: Lower-extremity edema was observed in 31 of 90 (34%) patients. Edema was less common in patients with claudication than in those with pain at rest (P = 0.016) or ischemic ulcers (P < 0.001), and it was less common in patients with pain at rest than in those with ischemic ulcers (P = 0.017). Treatment was typically limited to a brief course of oral diuretics. Conclusions: Vascular endothelial growth factor may enhance vascular permeability in humans. At the doses of plasmid DNA used in this study, lower-extremity edema responded to oral diuretic therapy and did not seem to be associated with serious sequelae.
158 DOWN REGULATION OF DIACYLGLYCEROL KINASE q ACTIVITY MEDIATES THE CYTOPROTECTIVE EFFECT OF HEPATIC PRECONDITIONING
Authors: G. Baldanzi, E. Alchera, C. Imarisio, M. Gaggianesi, C. Dal Ponte, P. Nitti, C. Domenicotti, E. Albano, A. Graziani, R. Carini
Journal: Journal of Hepatology (2009)
Prevention of Ventricular Arrhythmias Related to Paired Pacing.
Authors: Edwin L. Rothfeld
Journal: Annals of Internal Medicine (1969)

s1 May 1969Prevention of Ventricular Arrhythmias Related to Paired Pacing.Edwin L. Rothfeld, M.D., F.A.C.P., I. Richard Zucker, M.D.Edwin L. Rothfeld, M.D., F.A.C.P.Search for more papers by this author, I. Richard Zucker, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-70-5-1081_2 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptDespite the advent of coronary care units and more aggressive management of the patient with acute myocardial infarction, the mortality rate due to the cardiogenic-shock—low-output failure syndrome remains unacceptably high. Paired pacing has been suggested as a mode of therapy because of its powerful inotropic effects but has not been extensively used because of the hazard of producing ventricular fibrillation. Previous work in this laboratory has shown that paired pacing of the canine heart after coronary artery ligation results in fatal ventricular fibrillation. The purpose of this study was to observe the combined use of paired pacing and various antiarrhythmic... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: Edwin L. Rothfeld, M.D., F.A.C.P.; I. Richard Zucker, M.D.Affiliations: Newark, New Jersey PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byDrug-pacemaker interactions 1 May 1969Volume 70, Issue 5 Page: 1081-1081 Keywords Acute myocardial infarction Arrhythmia Cardiac care unit Coronary arteries Death rates Heart Ligation assay Research laboratories Ventricular fibrillation ePublished: 1 December 2008 Issue Published: 1 May 1969 PDF downloadLoading ...
Silver Jubilee of the “London Post”
Authors: Franz J. Ingelfinger
Journal: New England Journal of Medicine (1977)

1952 was a portentous year for the Journal. In the spring, Milton Paige came aboard.1 In the fall, in the issue of September 4 to be exact, another faithful crew member enlisted. As an editorial in that issue explained, "In view of this common denominator [i.e., the English language] it has seemed a fortunate circumstance to the editors of the Journal that a London 'correspondent' has been found who is willing to present from time to time an account of matters of general medical interest in Great Britain. Our reporter, whose first installment of 'By the London Post' appears . . .
Internal inquiry clears surgeon
Authors: C. Dyer
Journal: BMJ (1998)

Joseph Rahamim, the surgeon at the centre of concerns raised by Channel 4News about his qualifications, resumed work this week after a preliminary investigation by Plymouth Hospitals NHS Trust found that his death rates were comparable to national figures.

The trust set up the internal investigation after Channel 4 News revealed that Mr Rahamim, consultant thoracic surgeon at Derriford Hospital in Plymouth, was unaccredited and was the only thoracic surgeon in the country with no postgraduate surgical qualification (1 August, 297). This was not a barrier to appointment as a consultant at the time of his appointment in 1992.

The results …
Vincent Van Gogh And Glaucoma
Authors: Gladys Garrett
Journal: JAMA (1971)

<h3>To the Editor.—</h3> An article in the Los Angeles<i>Times</i>referred to the suggestion made by Maire of the possibility that Van Gogh had glaucoma (<b>217</b>:938, 1971). His paintings were used as clues; for example, one pupil was painted larger than the other. If you have the open-mindedness to listen to a nonlettered artist, there is much I can say on the subject of how the artist creates, but here will be only an abstract of my abstract art. The one who is an artist in the true sense of the word makes one eye larger, one higher, and, what is less apparent, one advancing and one receding. Another way to say it is that they are not exactly symmetrical, but this applies to all the planes on the canvas of the modern master, not just the eyes. Further, we can say that the two eyes would have a
Efficacy and safety of CD 271 alcoholic gels in the topical treatment of acne vulgaris
Authors: M. VERSCHOORE, A. LANGNER, H. WOLSKA, S. JABLONSKA, J. CZERNIELEWSKI, H. SCHAEFER
Journal: British Journal of Dermatology (1991)

Journal Article Efficacy and safety of CD 271 alcoholic gels in the topical treatment of acne vulgaris Get access M. VERSCHOORE, M. VERSCHOORE CIRD Galderma, Sophia Antipolis, Valbonne, France Dr M. Verschoore, CIRD Galderma, Sophia Antipolis, 06565 Valbonne, France. Search for other works by this author on: Oxford Academic Google Scholar A. LANGNER, A. LANGNER Department of Dermatology, Warsaw Academy of Medicine, Warsaw, Poland Search for other works by this author on: Oxford Academic Google Scholar H. WOLSKA, H. WOLSKA Department of Dermatology, Warsaw Academy of Medicine, Warsaw, Poland Search for other works by this author on: Oxford Academic Google Scholar S. JABLONSKA, S. JABLONSKA Department of Dermatology, Warsaw Academy of Medicine, Warsaw, Poland Search for other works by this author on: Oxford Academic Google Scholar J. CZERNIELEWSKI, J. CZERNIELEWSKI CIRD Galderma, Sophia Antipolis, Valbonne, France Search for other works by this author on: Oxford Academic Google Scholar H. SCHAEFER H. SCHAEFER CIRD Galderma, Sophia Antipolis, Valbonne, France Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 124, Issue 4, 1 April 1991, Pages 368–371, https://doi.org/10.1111/j.1365-2133.1991.tb00600.x Published: 01 April 1991
Short-term effect of orlistat on dietary glycotoxins in healthy women and women with polycystic ovary syndrome
Authors: Evanthia Diamanti-Kandarakis, Christina Piperi, Krystallenia Alexandraki, Nikolaos Katsilambros, Eirini Kouroupi, Joanna Papailiou, Stefanos Lazaridis, Ekaterini Koulouri, Helen A. Kandarakis, Emmanuel E. Douzinas, George Creatsas, Anastasios Kalofoutis
Journal: Metabolism (2006)
Accuracy of mortality data for interstitial lung diseases in New Mexico, USA.
Authors: D. B. Coultas, M. P. Hughes
Journal: Thorax (1996)

BACKGROUND: The sensitivity and accuracy of death certificates and mortality data as sources of population based data on the occurrence of interstitial lung diseases has received limited attention. To determine the usefulness of these data sources, death certificates and mortality data from patients in New Mexico were examined. METHODS: Patients with an interstitial lung disease were identified from a population based registry. For subjects who had died, diagnostic information from their death certificates and from mortality data was compared with the clinical diagnoses made before death. RESULTS: Of 385 patients with a clinical diagnosis of an interstitial lung disease, 134 died between October 1988 and August 1994. Death certificates were obtained for 96% of these patients. An interstitial lung disease was listed somewhere on the death certificate for only 46% of the patients, and as an immediate cause of death for only 15%. For the patients with an interstitial lung disease listed somewhere on the death certificate the overall concordance between the diagnoses before death and those on the death certificate was 76%. Mortality data for the State of New Mexico showed a diagnosis of interstitial lung disease to be the assigned cause of death for only 22% of the patients. The overall agreement between the diagnoses made before death and those of the state mortality data was only 21%. CONCLUSIONS: These results suggest that death certificates and state mortality data are neither sensitive nor accurate for describing the occurrence of interstitial lung diseases. This finding may partly explain the apparently low mortality rates from idiopathic pulmonary fibrosis in the USA compared with other countries.
Childhood Asthma: Pathophysiology and Treatment
Authors: Richard J. Bonforte
Journal: JAMA (1987)

Despite the amount of published material available, particularly in the pediatric literature, there remains a scarcity of information putting asthma into a clear and meaningful framework. The purpose of this textbook is clearly stated in the preface: "to assemble and integrate in one volume information about the latest information in this field, with an analysis and critique of clinical and basic approaches to the pathophysiology, diagnosis, and management of variable or 'reactive' airway disease." Despite this lofty aim, the editors have done an excellent job in selecting a group of contributors to assemble a series of articles that blend subjects of basic scientific and clinical importance. The result is an informative and practical volume. It is reflective of the quality of this text, and of the basic philosophy of the editors, that they chose Dr Elliot Ellis to write the foreword. Recognized as a premiere pediatric allergist, Dr Ellis is,