tbuckley/cabot-search huggingface dataset:
Coping With CLIA
Authors: J. Stephen Kroger
Journal: JAMA (1994)

Although most physicians support Congress' intent to improve the reliability of laboratory testing at all testing sites, they are frustrated and confused about what they must do to comply with the Clinical Laboratory Improvement Amendments (CLIA) of 1988.<sup>1</sup>And it is no wonder. The CLIA regulations have proliferated since the first rule was published on May 2,1990.<sup>2</sup>Extremely controversial, this proposed rule significantly restructured the approach to federal laboratory regulation by introducing rules that are based on the complexity of performing and evaluating tests. It provoked an unprecedented 60 000 written comments from physicians and laboratory professionals and forced the Health Care Financing Administration (HCFA) to seek input from the regulated community. A second proposed rule responding to this input was published by HCFA on February 28, 1992.<sup>3</sup>Additional rules have been published describing fees,<sup>4</sup>sanctions and enforcement procedures,<sup>5</sup>categories of tests classified by complexity,
Dermatophyte pseudomycetoma of the scalp: case report and review
Authors: F. Botterel, S. Romand, M. Cornet, G. Recanati, B. Dupont, P. Bouree
Journal: British Journal of Dermatology (2001)

Journal Article Dermatophyte pseudomycetoma of the scalp: case report and review Get access F. Botterel, F. Botterel Department of Tropical Diseases and Parasitology, AP‐HP, Bicêtre Hospital, Paris XI University, 78 rue du Général Leclerc, F‐94275 Le Kremlin‐Bicêtre cedex, France Dr Françoise Botterel.E‐mail: francoise.botterel@bct.ap‐hop‐paris.fr Search for other works by this author on: Oxford Academic Google Scholar S. Romand, S. Romand Department of Tropical Diseases and Parasitology, AP‐HP, Bicêtre Hospital, Paris XI University, 78 rue du Général Leclerc, F‐94275 Le Kremlin‐Bicêtre cedex, France Search for other works by this author on: Oxford Academic Google Scholar M. Cornet, M. Cornet Department of Tropical Diseases and Parasitology, AP‐HP, Bicêtre Hospital, Paris XI University, 78 rue du Général Leclerc, F‐94275 Le Kremlin‐Bicêtre cedex, France Search for other works by this author on: Oxford Academic Google Scholar G. Recanati, G. Recanati Department of Dermatology, Saint‐Germain‐en‐Laye‐Hospital, F‐78105 Saint‐Germain‐en‐Laye cedex, France Search for other works by this author on: Oxford Academic Google Scholar B. Dupont, B. Dupont Mycology Unit, Pasteur Institute, 28 rue du Dr E.Roux, F‐75015 Paris, France Search for other works by this author on: Oxford Academic Google Scholar P. Bourée P. Bourée Department of Tropical Diseases and Parasitology, AP‐HP, Bicêtre Hospital, Paris XI University, 78 rue du Général Leclerc, F‐94275 Le Kremlin‐Bicêtre cedex, France Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 145, Issue 1, 1 July 2001, Pages 151–153, https://doi.org/10.1046/j.1365-2133.2001.04301.x Published: 01 July 2001
Serum and synovial fluid levels of angiotensin converting enzyme in polyarthritis.
Authors: J.R Lowe, J.S Dixon, J.A Guthrie, P McWhinney
Journal: Annals of the Rheumatic Diseases (1986)

Serum levels of angiotensin converting enzyme (ACE) activity in patients with rheumatoid arthritis (RA) (n = 48), osteoarthritis (OA) (n = 11), ankylosing spondylitis (n = 24), psoriatic arthritis (n = 12), and Behçet's syndrome (n = 20) were not significantly different from those of normal controls (n = 26). Synovial fluid ACE activity was lower in OA than in RA but was similar when corrected for protein levels. An increase in serum ACE concentration in patients with RA receiving captopril therapy is in agreement with previous results. There was some correlation of ACE with erythrocyte sedimentation rate (ESR) and C reactive protein (CRP) but not with clinical indices in captopril treated patients. It is suggested that the beneficial actions of captopril in the treatment of RA are not due to its activity as an ACE inhibitor, but more probably a result of captopril being an aliphatic thiol.
Tc-99m-IDA Hepatobiliary Imaging
Authors: J. R. STY, D. P. BABBITT, W. SQUIRES
Journal: Clinical Nuclear Medicine (1979)

The authors describe the scintigraphic appearance of a fractured liver using a Tc-99m-IDA derivative. Tc-99m-IDA imaging provides both functional and morphologic information which is necessary in evaluating biliary tract trauma.
Systemic chemotherapy for primary breast cancer
Authors: M. McCracken
Journal: BMJ (1977)

response.The increasingly widespread use of drugs such as diazepam and the tendency to use Cremophor solubilisation to prevent thrombophlebitis and injection pain must increase the chances of clinical responses occurring.The next few years may well see an increasing number of reports of anaphylactoid phenomena to what have long been considered "safe" drugs.
Pralatrexate-induced tumor cell apoptosis in the epidermis of a patient with HTLV-1 adult T-cell lymphoma/leukemia causing skin erosions
Authors: Alexander G. Marneros, Marc E. Grossman, David N. Silvers, Sameera Husain, Gerard J. Nuovo, Barbara MacGregor-Cortelli, Ellen Neylon, Molly Patterson, Owen A. O'Connor, Jasmine M. Zain
Journal: Blood (2009)
The Train Is Leaving the Station
Authors: Burton J. Williams
Journal: New England Journal of Medicine (1994)

It is 7 a.m. I am sitting in a heroically proportioned lecture hall trying to focus my eyes. On a table in front of me, slightly blurred, sits what was advertised as a continental breakfast: lukewarm coffee in a styrofoam cup and a Danish, which is “continental” only in the sense that it may be a leftover from D-day.I am recovering from a bad night on call. Several assaults by telephone designed to make me “aware” of a problem at a nursing home reduced the architecture of my sleep to rubble. REM-less, my mind wanders. I catch myself thinking . . .
Perversions of Medical Technology
Authors: E. Trepman
Journal: JAMA (1990)

<h3>To the Editor.—</h3> The articles in the August 4 issue of<i>JAMA</i>on chemical weapons, biological warfare, and radiation safety are timely and important. However, we were disappointed that two articles that attempted to provide an historical review of these subjects failed to include some of the most blatant examples of misuse of chemical and radiation technology in war. Orient<sup>1</sup>discusses the German chemical industry during World War II, including the development of tabun and sarin by the Germans. However, she does not mention Zyklon B, the pellet form of a gas with a prussic acid base, which was used by the Germans to annihilate millions of Jewish and non-Jewish enemies of the Third Reich.<sup>2</sup>This fact is of particular importance to physicians because Zyklon B was tested and administered in mass murder with the active participation of the German medical profession.<sup>3</sup> Walker<sup>4</sup>documents some of
<i>L’escalier canadien</i>
Authors: Thomas B. Cole
Journal: JAMA (2015)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
More on Antibiotic Susceptibility of Bacteroides
Authors: ANTHONY W. CHOW
Journal: Annals of Internal Medicine (1971)

Letters, Comments, and Corrections1 November 1971More on Antibiotic Susceptibility of BacteroidesANTHONY W. CHOW, M.D., LUCIEN B. GUZE, M.D.ANTHONY W. CHOW, M.D.Search for more papers by this author, LUCIEN B. GUZE, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-75-5-810_1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: In relation to the question regarding choice of antibiotics for bacteroides sepsis, which has been discussed in recent letters in your journal (Ann Intern Med 75:316-317, 1971), our data (to be presented at the Interscience Conference on Antimicrobial Agents and Chemotherapy, Atlantic City, New Jersey, 17-22 October 1971) support the view of Drs. Bodner, Koenig, and Goodman that at present chloramphenicol may have a role in the treatment of bacteroides sepsis.We have measured the minimal inhibitory concentration (MIC) of several antibiotics by an agar dilution technique against 75 strains of bacteroides isolated from clinical material.Mueller-Hinton... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Harbor General Hospital Torrance, Calif. VA Hospital and UCLA School of Medicine Los Angeles, Calif. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 November 1971Volume 75, Issue 5Page: 810-810KeywordsAntibioticsAntimicrobialsAttentionBacteroidesChemotherapyChloramphenicolMinimum inhibitory concentrationSepsis Issue Published: 1 November 1971 PDF downloadLoading ...
NICE publishes osteoporosis guidance after more than six years of consultation
Authors: Z. Kmietowicz
Journal: BMJ (2008)

The UK National Institute for Health and Clinical Excellence (NICE) has published final guidance on the use of drugs to prevent primary and secondary osteoporotic fractures in postmenopausal women.

The guidance recommends a range of treatments, depending on a woman’s age, her bone density, and how many indicators of fragile bones or risk factors for fracture she has.

It recommends alendronic acid as the first line treatment for primary prevention in women aged 70 or over who are given a diagnosis of osteoporosis and who have a clinical risk factor for the condition or an indicator of low bone density.

NICE defines a diagnosis as a T score of −2.5 or below on dual energy …
Circles of Exclusion: The Politics of Health Care in Israel
Authors: David Chinitz
Journal: JAMA (2009)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The Body Cell Mass and Its Supporting Environment; Body Composition in Health and Disease.
Authors: John F. Maher
Journal: JAMA (1963)

Unlike the usual book on fluids and electrolytes this volume, based on the multiple isotope dilution technique, is a much more complete treatise on body composition. It is well organized and begins with sections on methodology, interpretation, calculation, and statistical methods, which are carefully described but are not easy reading compared to the rest of the text. The fourth chapter, which provides data on body composition in normal adults, is lengthened by some spacious graphs, often having very few coordinates illustrated. It does provide, however, a wealth of information which could serve as the standard of reference for this field. The second section applies the data to an abundance of clinical material, including some very fascinating case studies. The reader gains considerable knowledge of the distortions of body composition produced by various diseases. The authors recognize and discuss the many limitations of their study technique. Some of the automotive analogies,
Department of Veterans Affairs Cooperative Studies Program Clinical Trial Comparing Combined Warfarin and Aspirin With Aspirin Alone in Survivors of Acute Myocardial Infarction
Authors: Louis D. Fiore, Michael D. Ezekowitz, Mary T. Brophy, David Lu, Joseph Sacco, Peter Peduzzi
Journal: Circulation (2002)

Background — Both aspirin and warfarin when used alone are effective in the secondary prevention of vascular events and death after acute myocardial infarction. We tested the hypothesis that aspirin and warfarin therapy, when combined, would be more effective than aspirin monotherapy. Methods and Results — We conducted a randomized open-label study to compare the efficacy of warfarin (target international normalized ratio 1.5 to 2.5 IU) plus aspirin (81 mg daily) with the efficacy of aspirin monotherapy (162 mg daily) in reducing the total mortality in 5059 patients enrolled within 14 days of infarction and followed for a median of 2.7 years. Secondary end points included recurrent myocardial infarction, stroke, and major hemorrhage. Four hundred thirty-eight (17.3%) of 2537 patients assigned to the aspirin group and 444 (17.6%) of 2522 patients assigned to the combination group died (log-rank P =0.76). Recurrent myocardial infarction occurred in 333 patients (13.1%) taking aspirin and in 336 patients (13.3%) taking combination therapy (log-rank P =0.78). Stroke occurred in 89 patients (3.5%) taking aspirin and in 79 patients (3.1%) taking combination therapy (log-rank P =0.52). Major bleeding occurred more frequently in the combination therapy group than in the aspirin group (1.28 versus 0.72 events per 100 person years of follow-up, respectively; P &lt;0.001). There were 14 individuals with intracranial bleeds in both the aspirin and combination therapy groups. Conclusions — In post–myocardial infarction patients, warfarin therapy (at a mean international normalized ratio of 1.8) combined with low-dose aspirin did not provide a clinical benefit beyond that achievable with aspirin monotherapy.
Establishing a national inclusion programme
Authors: Jennifer Gosney
Journal: British Journal of Sports Medicine (2010)

Sir Murray Halberg set up the Halberg Trust after winning a gold medal at the 1960 Olympics in Rome. The Halberg Trust aims to ensure disabled children have the opportunity to participate in sport and active leisure of their choice. The methods taken over the past 50 years to achieve this goal have varied dramatically and grown with community and social change. The Halberg Trust currently has 15 staff around the country to promote inclusion of disabled people in sport and physical activity. The Sport Opportunity Advisors are all based at their regional sporting trusts and work in a project approach to develop community inclusion through one on one project work, education, training and funding.
Immunosuppressive and Cytotoxic Chemotherapy: Long-Term Complications
Authors: PHILIP S. SCHEIN
Journal: Annals of Internal Medicine (1975)

Cytotoxic drugs are being widely used as immunosuppressive and anti-inflammatory agents in patients with nonneoplastic conditions. In addition, patients with specific forms of malignancies have achieved substantial increases in survival as a result of improvements in cancer chemotherapy. Both of these patient populations are at risk for the development of long-term complications of treatment. Of particular concern is the problem of cumulative organ toxicity that is insidious in onset and not manifested clinically until damage has become severe and irreversible. In this review, specific examples of long-term toxicity are discussed to illustrate the complexity and importance of this increasingly common clinical problem.
Simple Clinical Prognostic Model for Hepatocellular Carcinoma in Developing Countries and Its Validation
Authors: Chee Kiat Tan, Ngai Moh Law, Han Seong Ng, David Machin
Journal: Journal of Clinical Oncology (2003)

Purpose: More than 80% of hepatocellular carcinomas (HCCs) worldwide occur in developing countries, especially in Asia. It often presents at an advanced stage beyond treatment. In this circumstance, a simple prognostic model is useful. Previous prognostic models require radiologic and laboratory investigations that are not readily available in developing countries. Our aim is to formulate and then validate a simple clinical prognostic model for HCC in an Asian population using only clinical parameters and with serum alpha-fetoprotein (AFP) as the sole laboratory test. Patients and Methods: Cox regression modeling was performed on several clinical parameters and serum AFP level in 397 patients with HCC who received only supportive care in Singapore. A later group of 324 HCC patients from an Asia-Pacific–wide randomized trial was then used to validate the model. Results: Ascites, physical performance status, and serum AFP were independently predictive of survival. Cox analysis yielded a simple score based on these three variables that categorizes patients into low-, medium-, and high-risk groups with 6-month survivals of 43%, 21%, and 5%, respectively. The prospective validation data provided corresponding estimates of 33%, 15%, and 3% and give confirmation of the utility of the simple model. Conclusion: We have formulated and prospectively validated a simple prognostic score for untreated HCC that only requires a clinical evaluation for ascites and physical performance status and measurement of serum AFP. This simple model is particularly apt for developing country circumstances and can also be used to select patients for treatment trials.
Th22 Cells Are an Important Source of IL-22 for Host Protection against Enteropathogenic Bacteria
Authors: Rajatava Basu, Darrell B. O’Quinn, Daniel J. Silberger, Trenton R. Schoeb, Lynette Fouser, Wenjun Ouyang, Robin D. Hatton, Casey T. Weaver
Journal: Immunity (2012)
Systematic Screening Identifies Dual PI3K and mTOR Inhibition as a Conserved Therapeutic Vulnerability in Osteosarcoma
Authors: Ankita Gupte, Emma K. Baker, Soo-San Wan, Elizabeth Stewart, Amos Loh, Anang A. Shelat, Cathryn M. Gould, Alistair M. Chalk, Scott Taylor, Kurt Lackovic, Åsa Karlström, Anthony J. Mutsaers, Jayesh Desai, Piyush B. Madhamshettiwar, Andrew C.W. Zannettino, Chris Burns, David C.S. Huang, Michael A. Dyer, Kaylene J. Simpson, Carl R. Walkley
Journal: Clinical Cancer Research (2015)

Osteosarcoma is the most common cancer of bone occurring mostly in teenagers. Despite rapid advances in our knowledge of the genetics and cell biology of osteosarcoma, significant improvements in patient survival have not been observed. The identification of effective therapeutics has been largely empirically based. The identification of new therapies and therapeutic targets are urgently needed to enable improved outcomes for osteosarcoma patients.We have used genetically engineered murine models of human osteosarcoma in a systematic, genome-wide screen to identify new candidate therapeutic targets. We performed a genome-wide siRNA screen, with or without doxorubicin. In parallel, a screen of therapeutically relevant small molecules was conducted on primary murine- and primary human osteosarcoma-derived cell cultures. All results were validated across independent cell cultures and across human and mouse osteosarcoma.The results from the genetic and chemical screens significantly overlapped, with a profound enrichment of pathways regulated by PI3K and mTOR pathways. Drugs that concurrently target both PI3K and mTOR were effective at inducing apoptosis in primary osteosarcoma cell cultures in vitro in both human and mouse osteosarcoma, whereas specific PI3K or mTOR inhibitors were not effective. The results were confirmed with siRNA and small molecule approaches. Rationale combinations of specific PI3K and mTOR inhibitors could recapitulate the effect on osteosarcoma cell cultures.The approaches described here have identified dual inhibition of the PI3K-mTOR pathway as a sensitive, druggable target in osteosarcoma, and provide rationale for translational studies with these agents.
<i>Anisakis simplex</i>, a relevant etiologic factor in acute urticaria
Authors: M. D. Del Pozo, M. Audicana, J. M. Diez, D. Muñoz, I. J. Ansotegui, E. Fernández, M. García, M. Etxenagusia, I. Moneo, L. Fernández de Corres
Journal: Allergy (1997)

Del Pozo MD, Audícana M, Diez JM, Muñoz D, Ansotegui IJ, Fernández E, García M, Etxenagusia M, Moneo I, Fernández de Corres L. Anisakis simplex , a relevant etiologic factor in acute urticaria. Anisakis simplex , a parasite of fish and cephalopods, can induce IgE‐mediated reactions. This study aimed to determine the etiologic role of A. simplex in patients affected by urlicaria/angioedema ‘AE’ or anaphylaxis. We studied 100 adult subjects suffering acute episodes of urticaria/AE, by anamnesis, prick tests with A. simplex and fish‐mix extracts, and total and specific IgE to both A. simplex and cod. The following criteria of A. simplex allergy were considered: 1’ urticaria/AE within 6 h after fish ingestion; 2’ specific IgE to A. simplex; 3’ positive prick test to A. simplex extract; 4’ exclusion of other suspected causes. Double‐blind, placebo‐controlled food challenge was not carried out because ethical considerations forbid challenge with a parasite. Specific IgE to A. simplex ‘&lt;0.7 kU/1’ was found in 22 subjects, but only eight were diagnosed as having A. simplex allergy. Other allergens were involved in 37 patients, and 55 cases were considered idiopathic. Specific IgE to fish ‘&lt;0.7 kU/1’ was found in two patients, but only one was diagnosed as having fish allergy. We concluded that A. simplex is an important etiologic factor in acute urticaria. We suggest that it should be considered in cases of urticaria/AE or anaphylaxis, especially after fish ingestion.
PROPHYLACTIC TREATMENT IN THE PREVENTION OF VENEREAL DISEASE
Authors: MORRIS C. THRUSH
Journal: JAMA (1918)

During the past couple of decades, the trend of medicine has been steadily and progressively toward preventive rather than curative medicine. In no domain of medical science has this principle been more strongly exemplified than in the sanitary measures that are being utilized to protect the health of the soldier in the United States Army. For a long time the great bane of all armies has been the venereal problem, and the same applies to navies. The United States government, realizing the great necessity of curbing this evil, has adopted certain regulations which have been of the greatest service. These regulations are four in number:   General orders concerning venereal diseases, requiring men who expose themselves to the danger of contracting venereal diseases to report at once for prophylactic treatment on return to the camp; with trial by court martial for neglect of duty, for any soldier who fails to comply