THE CHEMOTHERAPY OF UREASE- AND CITRASE- PRODUCING BACTERIA OF THE URINARY TRACT
Authors: H SENECA, J K LATTIMER, H H ZINSSER
Journal: Annals of Internal Medicine (1960)

Article1 September 1960THE CHEMOTHERAPY OF UREASE- AND CITRASE- PRODUCING BACTERIA OF THE URINARY TRACTHARRY SENECA, M.D., F.A.C.P., JOHN K. LATTIMER, M.D., F.A.C.S., HANS H. ZINSSER, M.D.HARRY SENECA, M.D., F.A.C.P.Search for more papers by this author, JOHN K. LATTIMER, M.D., F.A.C.S.Search for more papers by this author, HANS H. ZINSSER, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-53-3-468 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptINTRODUCTIONBeginning with the premise that magnesium ammonium phosphate stones formed in the urinary tract were primarily the result of the enzymatic urea-splitting capacities of some types of urinary tract pathogens, both Gram-positive and Gram-negative, the possibilities of blocking this enzyme were explored by Walberg from 1951 to 1956.1The kinetics and characteristics of some of the bacterial urea-splitting enzymes were elucidated, and several potent inhibitors were described.1Shortly after this approach was applied clinically, it was found that the capacity of chlormerodrin to change the urinary pH to the acid side resulted in considerable dissolution of struvite stones within...Bibliography1. Walberg CB: The purification and properties of bacterial urease, thesis, University of Southern California School of Medicine, 1957. Google Scholar2. ZinsserLattimerSeneca HHJKH: Aerogenosis: a plea for clinical bacteriology, to be published. Google Scholar3. LattimerSenecaZinsserTroc JKHHHOK: Increasing seriousness of resistant urinary infections with Aerobacter aerogenes , J. A. M. A. 170: 938, 1959. CrossrefMedlineGoogle Scholar4. Seneca H: Aerobacter aerogenes bacteremia and bacilluria, Surg., Gynec. and Obst. 108: 733, 1959. MedlineGoogle Scholar5. SenecaTroc HOK: Implications of maximal bacterial resistance to antibiotics, Postgrad. Med. 26: 457 (Oct.) 1959. CrossrefMedlineGoogle Scholar6. SenecaZinsserLattimer HHHJK: Relation of drug resistance to enzyme activity among coliform bacteria, J. A. M. A. 172: 1015, 1960. CrossrefMedlineGoogle Scholar7. Hellerman L: Reversible inactivation of certain hydrolytic enzymes, Physiol. Rev. 17: 454, 1937. CrossrefGoogle Scholar8. WackerVallee WEBL: Nucleic acids and metals, J. Biol. Chem. 234: 3257, 1959. CrossrefGoogle Scholar9. WackerFuwaDruyan WEKR: Structural determinants of RNA, Federation Proc. 19: 319 (Mar.) 1960. Google Scholar10. FelsenfeldHuang GS: The interaction of polynucleotides with metal ions, amino acids and polyamines, Biochim. et Biophys. Acta 37: 425 (Jan. 29) 1960. CrossrefMedlineGoogle Scholar11. Johnson RG: Prevention and dissolution of calculi in rats with fluoroacetate and citric acid, J. Urol. 82: 261 (Aug.) 1959. CrossrefMedlineGoogle Scholar12. SenecaMilnerTroc HPOK: Clinical laboratory classification of proteus on the basis of its biochemical potentialities, Read before the Association for the Advancement of Science, Dec., 1959. Google Scholar13. SenecaMilnerTroc HPOK: Enzyme profile of B. proteus , to be published. Google Scholar14. WhiteNuhfer SPA: The diuretic activity and urinary excretion of three new mercurial compounds when administered intravenously, J. Pharmacol. and Exper. Therap. 101: 38, 1951. Google Scholar15. Catlin BW: Interspecific transformation of neisseria by culture slime containing deoxyribonucleate, Science 131: 608 (Feb.) 1960. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: New York, N. Y.*Received for publication April 25, 1960.Presented at the Forty-first Annual Session of The American College of Physicians, San Francisco, California, April 6, 1960.From the Department of Urology, Columbia University College of Physicians & Surgeons, New York, N. Y.Requests for reprints should be addressed to Harry Seneca, M.D., Columbia University (P & S), New York 32, N. Y. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byEffect of Organic Mercurials and Sulfhydryl Compounds on the Urease Activity of Proteus : Inhibition by Urine and Ascorbic AcidQuecksilberhaltige DiureticaBACTERIAL MUTATION AND THE EVOLUTION OF DRUG RESISTANCE IN RELATION TO CHEMOTHERAPY*Experimental Pharmacology and Toxicology of SulfonamidesRenal calculiRENAL CALCULI ASSOCIATED WITH HYPEROXALURIA*Bacillus Proteus: Clinical Laboratory ClassificationUrease and Citrase of Pathogenic and Saprophytic FungiChlormerodrin Treatment for Experimental Urolithiasis in Presence of Urea-splitting InfectionChanges in Bacterial Enzyme Patterns, Drug Susceptibility and Chemotherapy Through Enzyme Blocking AgentsMicrobial UreaseThe relationship between drug susceptibility patterns and enzyme patterns in pathogenic gram-positive cocci 1 September 1960Volume 53, Issue 3Page: 468-474KeywordsBacterial pathogensEnzymesEpidermal growth factorSalmonellaShigellaStreptococcus pyogenesSurgeonsUreasesUrologyVibrio ePublished: 1 December 2008 Issue Published: 1 September 1960 PDF downloadLoading ...