RENAL TUBULAR FAILURE OF SHOCK AND NEPHRITIS
Authors: D D VAN SLYKE
Journal: Annals of Internal Medicine (1954)

Article1 October 1954RENAL TUBULAR FAILURE OF SHOCK AND NEPHRITISDONALD D. VAN SLYKEDONALD D. VAN SLYKESearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-41-4-709 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe manner in which tubular injury can cause excretory failure was observed by A. N. Richards in 1929.1He watched through a microscope the nephrons of frogs that had been poisoned with sublethal doses of mercuric chloride, bichromate and other nephrotoxic poisons. Blood circulation and filtration in the glomeruli went on at a normal rate, but the entire filtrate was reabsorbed in the tubules, with resultant anuria. Richards concluded: "The only explanation which I can reach is that, under these conditions, the osmotic pressure of the blood proteins is unobstructed by the normal qualities of the tubular epithelium and is...Bibliography1. Richards AN: Direct observations of change in function of the renal tubule by certain poisons, Tr. A. Am. Physicians 44: 64, 1929. Google Scholar2. Bywaters EG: Ischemic muscle necroses. Crushing injury, traumatic edema, the crush syndrome, traumatic anuria, compression syndrome: a type of injury seen in air-raid casualties following burial beneath debris, J. A. M. A. 124: 1103, 1944. CrossrefGoogle Scholar3. BywatersBeall EGD: Crush injuries with impairment of renal function, Brit. M. J. 1: 427, 1941. CrossrefMedlineGoogle Scholar4. BywatersDible EGJH: The renal lesion in traumatic anuria, J. Path. and Bact. 54: 111, 1942. CrossrefGoogle Scholar5. Churchill ED: Personal communication. Google Scholar6. Brun C: Acute anuria. 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PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByA History of Uremia ResearchEmergence of the Concept of Acute Kidney InjuryRenal Blood Flow in Acute Epidemic Nephritis (Nephropathia Epidemica of Scandinavia)Elektronenmikroskopische Befunde an Kaninchennieren nach orthostatischem KollapsAkute Nierenver�nderungen nach HistaminschockAkutes NierenversagenEffect of the cardiac arrhythmias on the renal and mesenteric circulationsDie allgemeine Pathologie des BlutkreislaufesEffect of shock and of vasopressor drugs on the regional circulation of the brain, heart, kidney and liverAcute renal insufficiency following aortic surgeryBeitrag zur Morphologie der Niere beim akuten NierenversagenDie Analyse der Nierenfunktion Grundlagen und klinischer AussagewertSchock und KollapsRenal Tubular Damage in Infantile Gastro-enteritisDie Pathomorphologie der NierenausscheidungMorphologische Grundlagen akuter extrarenal bedingter NierenfunktionsstörungenSyndromes of Acute Renal FailureCardiac Arrest 1 October 1954Volume 41, Issue 4Page: 709-738KeywordsBloodChloridesEpitheliumNephritisNephronsOsmotic pressureProteinsRenal failureResearch laboratoriesShock Issue Published: 1 October 1954 PDF DownloadLoading ...