SALICYLATE TOXICITY: THE PROBABLE MECHANISM OF ITS ACTION
Authors: C M CARAVATI, E F COSGROVE
Journal: Annals of Internal Medicine (1946)

Article1 April 1946SALICYLATE TOXICITY: THE PROBABLE MECHANISM OF ITS ACTIONCHARLES M. CARAVATI, F.A.C.P., EDGAR F. COSGROVECHARLES M. CARAVATI, F.A.C.P.Search for more papers by this author, EDGAR F. COSGROVESearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-24-4-638 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptFor years it has been customary to administer alkalis in conjunction with oral salicylate therapy, based on the assumption that sodium bicarbonate protects the stomach by inhibiting the release of salicylic acid.1However, not until the recent work of Coburn2has it become customary to administer massive doses of salicylates over a protracted period. He advocates the intravenous and oral administration of sodium salicylate until a blood plasma level of over 300 gammas per c.c. is reached, and recommends that it be maintained at a high level for some weeks. In the application of this therapeutic procedure in our hands,...Bibliography1. SCHNEDORFBRADLEYIVY JGWBAC: Effect of salicylic acid upon gastric activity, and the modifying action of calcium gluconate and sodium bicarbonate, Am. Jr. Digest. Dis., 1935, iii, 239-244. Google Scholar2. COBURN AF: Salicylate therapy in rheumatic fever, a rational technique, Bull. Johns Hopkins Hosp., 1943, lxxiii, 435-464. Google Scholar3. SMULLWEGRIALELAND CRJ: The effect of sodium bicarbonate on serum salicylate level during salicylic therapy of patients with acute rheumatic fever, Jr. Am. Med. Assoc., 1944, cxxv, 1173-1175. CrossrefGoogle Scholar4. HURSTLINTOTT AGA: Aspirin haematemesis—clinical and gastroscopic study, Guy's Hosp. Rep., 1939, lxxxix, 173-183. Google Scholar5. PAUL WD: The effect of aspirin on gastric mucosa, Jr. Iowa Med. Soc., 1943, xxxiii, 155-158. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Pittsburgh, Pa.*Received for publication August 27, 1945. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byAspirin and the SalicylatesGastric Mucosal Damage Caused by Plain and Microencapsulated Acetylsalicylic Acid Tablets in Healthy Subjects: A Gastrocamera StudyParenteral aspirin produces and enhances gastric mucosal lesions and bleeding in ratsSalicylate Effects on Gastric Acid SecretionThe role of acid in the pathogenesis of aspirin-induced gastrointestinal erosions and hemorrhageEffects of route of administration on the production of gastric hemorrhage in the rat by aspirin and sodium salicylateGastrointestinal Haemorrhage, Gastric Ulcer and AspirinA Pharmacological Analysis of AspirinGastroscopic findings and fecal blood loss following aspirin administrationAspirin and gastrointestinal bleedingThe Metabolic Basis of the Major Symptoms in Acute Salicylate IntoxicationRelationship between lesion production, absorption, and distribution of 14C-labeled acetylsalicylic acidEffect of aspirin on gastric secretionThe Effect of Salicylates upon the Stomachs of DogsTHE MECHANISM OF THE EMETIC ACTION OF SODIUM SALICYLATETopical Action of Salicylates in Gastrointestinal Erosion and HemorrhageAspirin and gastric bleeding: Further studies of calcium aspirinAspirin and gastric bleedingGastric Secretion in Relation to Gastrointestinal Bleeding from Salicylate CompoundsPhysicochemical Basis of the Buffered Acetylsalicylic Acid ControversyGastric Secretory Studies During Prolonged Salicylate Administration in a Comatose ManSalicylates and Gastric HemorrhageSpecific Therapy for SalicylismSALICYLATES IN RHEUMATIC FEVER DIFFICULTIES EXPERIENCED IN TREATING CHILDREN WITH LARGE DOSESThe Medicinal Treatment of Acute Rheumatic FeverDie Krankheiten des MagensSalicylates, Hormones and Penicillin in the Treatment of Rheumatic FeverPlasma-Volume Determinations in Rheumatic Subjects during Oral Salicylate TherapyThe Treatment of Acute Rheumatic Fever 1 April 1946Volume 24, Issue 4Page: 638-642KeywordsBicarbonatesBlood plasmaOral administrationSalicylatesSodiumStomachToxicity ePublished: 1 December 2008 Issue Published: 1 April 1946 PDF downloadLoading ...