tbuckley/cabot-search huggingface dataset:
Abstract P1-03-05: Genetic variant in the OPG gene is associated with aromatase inhibitor-related musculoskeletal toxicity in breast cancer patients
Authors: Anneleen Lintermans, Kathleen Van Asten, Annouschka Laenen, Thomas Van Brussel, Johan Verhaeghe, Dirk Vanderschueren, Diether Lambrechts, Patrick Neven
Journal: Cancer Research (2015)

Abstract Background Aromatase inhibitor (AI) therapy is associated with musculoskeletal toxicity, which adversely affects quality of life and therapy adherence. Our objective was to evaluate genetic predictors for endocrine therapy-related musculoskeletal pain in a prospective cohort study, which was previously published. Patients &amp; methods 254 early breast cancer patients starting AI (n=159) or tamoxifen therapy (n=95) were included in this genetic biomarker study. Musculoskeletal symptoms were assessed at baseline and at 3, 6 and 12 months thereafter. AI-induced musculoskeletal pain was defined as an increase in arthralgia or myalgia relative to baseline. Single nucleotide polymorphisms (SNP) in candidate genes involved in estrogen signaling or reported to have associations with AI-related musculoskeletal pain or estrogen levels were selected. Of the 40 selected SNPs, 7 failed genotyping and were excluded from further analysis. Results Twenty SNPs exhibited a minor allele frequency &amp;lt;0.05 and were omitted from the final analysis. Overall, 13 SNPs in CYP19, CYP17, osteoprotegerin (OPG) and estrogen receptor 1 were included. 74% of AI-users reported new or worsened musculoskeletal pain compared to 33% of tamoxifen-treated patients. The OPG SNP rs2073618 was significantly associated with AI-induced musculoskeletal toxicity after correction for multiple testing (p=0.039). None of the other SNPs showed significant associations, both in AI and tamoxifen-treated patients. Conclusion The SNP rs2073618 in OPG predicts the risk of musculoskeletal symptoms with AI therapy, which has not been reported so far. Validation of this finding and further functional studies are needed. Citation Format: Anneleen Lintermans, Kathleen Van Asten, Annouschka Laenen, Thomas Van Brussel, Johan Verhaeghe, Dirk Vanderschueren, Diether Lambrechts, Patrick Neven. Genetic variant in the OPG gene is associated with aromatase inhibitor-related musculoskeletal toxicity in breast cancer patients [abstract]. In: Proceedings of the Thirty-Seventh Annual CTRC-AACR San Antonio Breast Cancer Symposium: 2014 Dec 9-13; San Antonio, TX. Philadelphia (PA): AACR; Cancer Res 2015;75(9 Suppl):Abstract nr P1-03-05.
Community pharmacy supply of emergency contraception
Authors: P. Bissell, C. Anderson, L. Bacon, B. Taylor, K. O'Brien, G. Ward
Journal: BMJ (2001)

EDITOR—Stammers in his letter expresses anxiety about the supply of emergency hormonal contraception in community pharmacies and the effect this may have on the spread of sexually transmitted infections. He says that women in need of emergency hormonal contraception will be at risk of sexually transmitted infections. But many of these women are using the contraceptive pill and have forgotten to take it, or are in stable relationships. These women are not at increased risk of contracting infections, and pharmacy supply will have no impact on their spread. If a woman is attending for emergency contraception because of a burst condom or an episode of unprotected sex, there is a risk of contracting sexually transmitted infections, but the level of risk is not directly affected by the wider availability of emergency contraception in the pharmacy. If women are at risk of sexually transmitted infections they do not need an emergency intrauterine device: the quick and accessible supply of levonorgestrel is even more pertinent here.
Heart failure with preserved ejection fraction induces molecular, mitochondrial, histological, and functional alterations in rat respiratory and limb skeletal muscle
Authors: T. Scott Bowen, Natale P. L. Rolim, Tina Fischer, Fredrik H. Bækkerud, Alessandra Medeiros, Sarah Werner, Eivind Brønstad, Oivind Rognmo, Norman Mangner, Axel Linke, Gerhard Schuler, Gustavo J. J. Silva, Ulrik Wisløff, Volker Adams
Journal: European Journal of Heart Failure (2015)
957. bcl-xL Antisense Oligonucleotides as an Enhancer of the Cytotoxic Effects of Cisplatin, Mitomycin C and Paclitaxel in the Treatment of Bladder Cancer
Authors: Axel Schaaf, Sreedhar Sagi, Sigrun Langbein, Lutz Trojan, Peter Alken, Maurice S. Michel
Journal: Molecular Therapy (2004)
Pulmonary Circulation-A Handbook for Clinicians
Journal: Thorax (1996)

Letters to the Editor drug.We consider that this leaves insufficient time for reliable identification ofthe offending drug or drugs.We agree that the drugs should probably be re-introduced in this order.A further difficult problem is the re-in- troduction of chemotherapy after an episode of acute liver failure.Certainly it is our policy, as discussed by Mitchell et al,' to change to drugs with no history of hepatotoxicity in patients fortunate enough to have survived this complication.
Abstract 18: MicroRNA-103 induces DNA damage and radiosensitizes the tumor vasculature
Authors: Sudarshan Anand, Sunil J. Advani, David A. Cheresh
Journal: Cancer Research (2014)

Abstract While it is well known that tumor vasculature is a key determinant of resistance to radiotherapy, there remains a paucity of agents that sensitize this compartment to clinical doses of radiation. Using an expression screen for ‘apoptomiRs’ induced by high dose radiation, we have identified microRNA-103 as a potent, genotoxic stress responsive apoptomiR in endothelial cells. Functionally, ectopic expression of miR-103 mimics genotoxic stress causing DNA double strand breaks leading to cell death and decreased retinal angiogenesis in mice . Mechanistically, we show that miR-103 targets DNA repair pathway components - the exonuclease TREX1 and the adaptor FANCF. Finally, miR-103 injection in mice decreased tumor burden in a human colorectal cancer xenograft model where it enhanced the effects of low dose radiation. Our data uncovers a microRNA mediated pathway of DNA damage unique to proliferating endothelium that can be exploited for radiosensitization of tumor vasculature. Citation Format: Sudarshan Anand, Sunil J. Advani, David A. Cheresh. MicroRNA-103 induces DNA damage and radiosensitizes the tumor vasculature. [abstract]. In: Proceedings of the 105th Annual Meeting of the American Association for Cancer Research; 2014 Apr 5-9; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2014;74(19 Suppl):Abstract nr 18. doi:10.1158/1538-7445.AM2014-18
Abstract P207: Incidence of Hypertension in Colombia Similar to That Observed Decades Ago in Developed Countries: An Observation From the Chicamocha Cohort Study
Authors: Juan C Villar, Luz X Martínez, Yeny Z Castellanos, Skarlet M Vásquez, Víctor M Herrera
Journal: Circulation (2015)

Background: Overweight is a modifiable risk factor for high blood pressure (BP). Despite the increasing prevalence of both conditions in the Latin American population, there are no estimates of either the incidence of hypertension or the impact of overweight on it that inform the design and evaluation of individual and community-based preventive interventions in the region. Methods: We conducted a prospective cohort study in a sample of normotensive, blood donors from Bucaramanga, Colombia, who were free of transfusion-transmitted infectious and cardiovascular diseases at baseline. Participants were re-evaluated after a median follow-up of 12 years to determine the incidence of hypertension defined as: 1) Self-reported diagnosis with evidence of pharmacological treatment; 2) Systolic BP &gt;140 mmHg or diastolic BP &gt;90 mmHg (average of two measures in seated position); or 3) Current systolic/diastolic BP &gt;120/80 mmHg with evidence of increments &gt;10/5 mmHg from baseline. We estimated crude incidence rates of hypertension and age- and sex-adjusted hazard ratios (HRs) for baseline overweight (body mass index ≥25 kg/m2) using Cox regression analysis. The population attributable fraction (PAF) for overweight was also assessed. Results: We followed 594 participants (baseline mean age = 38.0 years; 64% male; adherence rate = 78%) at risk of hypertension among which we observed 164 incident cases: Cumulative incidence of 27.6%; incidence rate of 23.4 cases per 1,000 person-years. Incidence rate was similar in men and women (23.4 vs. 23.2 per 1,000 person-years; p&gt;0.05) and tended to increase with age (17.4, 21.2, and 27.8 per 1,000 person-years among participants &lt;30, 30-39, and ≥40 years old, respectively; p&gt;0.05). Participants with overweight at baseline had twice the risk of developing hypertension than participants with normal weight (adjusted-HR = 2.00, 95%CI: 1.11, 3.61). The estimated PAF was 25.7%, considering a national prevalence of overweight equal to 34.6%. Conclusion: The incidence of hypertension in our study is similar to that reported two decades ago in cohorts from developed countries, which is consisting with the ongoing epidemiological transition in Latin America. We also confirmed the role of overweight as a risk factor for hypertension, accounting for about 1 out 4 incident cases. This finding highlights the importance of addressing overweight in our population.
The Treatment of Angina Pectoris
Authors: Harlow Brooks
Journal: Annals of Internal Medicine (1929)

Article1 September 1929The Treatment of Angina PectorisHARLOW BROOKSHARLOW BROOKSSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-3-3-242 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptAngina pectoris is not a disease, but a symptom complex. It has a widely varied etiological pathology which produces, nonetheless, a symptomatic picture of very striking and significant character, best as first described by Heberden in 1768.The pathology, basically concerned is the cause of death in angina pectoris. All or any of these lesions may exist without the appearance of the symptom complex and the pathological changes are in themselves probably quite as likely to cause sudden or ultimate death without angina as with it. The symptoms of angina in themselves are not lethal, they may probably exist or... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: New York City*Read before the American College of Physicians, April 9, 1929, Boston, Mass. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 September 1929Volume 3, Issue 3Page: 242-251KeywordsAnginaLesions ePublished: 1 December 2008 Issue Published: 1 September 1929 PDF downloadLoading ...
Abstract 4063: Potential targets of PTP4A3 involved in uveal melanoma migration
Authors: Geraldine Liot, Oceane Anezo, Cecile Laurent, Selma Maacha, Nathalie Planque, Simon Saule
Journal: Cancer Research (2014)

Abstract Uveal melanoma (UM) is the most frequent eye cancer in the adulthood and it represents 4-5% of all melanomas. Although at diagnosis over 95% of patients have disease limited to the eye, about 50% will develop metastases after a median time of three years. From transcriptomic study, we identified PTP4A3/PRL3 level as an efficient predictor of patient's survival. Overexpression of PTP4A3 in UM OCM-1 increased both cell migration and invasiveness. We then got interested in identifying downstream targets of PTP4A3 and more precisely proteins linked to cytoskeleton. We first highlighted collapsin Response Mediator Protein (CRMP2) by 2-D electrophoresis of phosphorus-enriched UM OCM1 stably-expressing PTP4A3 or an inactive catalytic mutant of PTP4A3 (C104S). CRMP2 was dephosphorylated in presence of PTP4A3. CRMP2 expression in UM is inversely correlated with that of PTP4A3, suggesting an antagonistic role of these proteins in tumor progression. Through the use of shRNA in OCM-1, the downregulation of CRMP2 led to an increase in cell migration of PTP4A3-expressing OCM1. In addition, we focused on ATIP3, a protein encoded by the gene MTUS1, which binds to microtubules. In breast cancer, MTUS1 expression was shown to be downregulated in highly proliferative breast carcinomas of poor clinical outcome. Similarly, our transcriptomic analysis showed that expressions of PTP4A3 and MTUS1 were anti-correlated, suggesting that the reduction of MTUS1 gene and ATIP3 expression in UM would be of bad prognosis. In our OCM1 cells, we demonstrated that ATIP3 overexpression blocks proliferation however effect of ATIP3 overexpression on cell migration still need to be elucidaded.In conclusion, CRMP2 and ATIP3 may play a role in the metastatic process of UM tumors expressing high levels of the phosphatase. Citation Format: Geraldine Liot, Oceane Anezo, Cecile Laurent, Selma Maacha, Nathalie Planque, Simon Saule. Potential targets of PTP4A3 involved in uveal melanoma migration. [abstract]. In: Proceedings of the 105th Annual Meeting of the American Association for Cancer Research; 2014 Apr 5-9; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2014;74(19 Suppl):Abstract nr 4063. doi:10.1158/1538-7445.AM2014-4063
80. A Rapid and Effective Lentivirus Purification Procedure
Authors: Natalia Landazuri, Joseph M. Le Doux
Journal: Molecular Therapy (2004)

During production of recombinant retroviruses, packaging cell lines secrete molecules that later act as inhibitors of transduction. We analyzed the effect of these inhibitors in stocks of amphotropic retroviruses produced by two different packaging cell lines: ψ-CRIP derived from NIH 3T3 fibroblasts and TELCeB6-A derived from TE671 cells. Virus stocks from TELCeB6-A had titers 1000-fold higher than those from ψ-CRIP, but contained high concentrations of inhibitors. Surprisingly, due to inhibition, the efficiency of transduction using undiluted virus stocks from TELCeB6-A was lower than that obtained with undiluted stocks from ψ-CRIP. Inhibition appeared to be partly due to free envelope protein, which limited early steps of gene transfer, and partly due to other molecules that acted at late steps of gene transfer. We found that it was possible to rapidly and easily purify stocks from transduction inhibitors by selectively flocculating virus particles with combinations of oppositely charged polymers, and pelleting the flocs by low speed centrifugation in a table-top centrifuge. The pellet concentrated most of the virus particles initially present in solution, but did not concentrate the inhibitors. When using stocks of retroviruses produced by TELCeB6-A, removal of the conditioned medium (supernatant) and resuspension of the inhibitor-free pellet in fresh medium resulted in more than a 70-fold enhancement of gene transfer. The implications of these findings with respect to the purification and processing of retroviruses for the purposes of human gene therapy will be discussed.
Alexithymia – an Inherited Trait?
Authors: Astrid Heiberg, Arvid Heiberg
Journal: Psychotherapy and Psychosomatics (1977)

Other Types| February 16 2010 Alexithymia – an Inherited Trait? / Discussion: A Study of Twins Subject Area: Psychiatry and Psychology Astrid Heiberg; Astrid Heiberg Psychiatric Institute, and Institute of Medical Genetics, University of Oslo, Oslo Search for other works by this author on: This Site PubMed Google Scholar Arvid Heiberg Arvid Heiberg Psychiatric Institute, and Institute of Medical Genetics, University of Oslo, Oslo Search for other works by this author on: This Site PubMed Google Scholar Psychother Psychosom (1977) 28 (1-4): 221–229. https://doi.org/10.1159/000287066 Article history Published Online: February 16 2010 Content Tools Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Facebook Twitter LinkedIn Email Tools Icon Tools Get Permissions Cite Icon Cite Search Site Citation Astrid Heiberg, Arvid Heiberg; Alexithymia – an Inherited Trait? / Discussion: A Study of Twins. Psychother Psychosom 31 December 1977; 28 (1-4): 221–229. https://doi.org/10.1159/000287066 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAll JournalsPsychotherapy and Psychosomatics Search Advanced Search Article PDF first page preview Close Modal This content is only available via PDF. 1977Copyright / Drug Dosage / DisclaimerCopyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher.Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. You do not currently have access to this content.
Diversity, cellular origin and autoreactivity of antibody-secreting cell population expansions in acute systemic lupus erythematosus
Authors: Christopher M Tipton, Christopher F Fucile, Jaime Darce, Asiya Chida, Travis Ichikawa, Ivan Gregoretti, Sandra Schieferl, Jennifer Hom, Scott Jenks, Ron J Feldman, Ramit Mehr, Chungwen Wei, F Eun-Hyung Lee, Wan Cheung Cheung, Alexander F Rosenberg, Iñaki Sanz
Journal: Nature Immunology (2015)
Evidence for symmetric chromosomal inversions around the replication origin in bacteria
Authors: Jonathan A Eisen, John F Heidelberg, Owen White, Steven L Salzberg
Journal: Genome biology (2000)

Whole-genome comparisons can provide great insight into many aspects of biology. Until recently, however, comparisons were mainly possible only between distantly related species. Complete genome sequences are now becoming available from multiple sets of closely related strains or species. By comparing the recently completed genome sequences of Vibrio cholerae,Streptococcus pneumoniae and Mycobacterium tuberculosis to those of closely related species - Escherichia coli, Streptococcus pyogenes and Mycobacterium leprae, respectively - we have identified an unusual and previously unobserved feature of bacterial genome structure. Scatterplots of the conserved sequences (both DNA and protein) between each pair of species produce a distinct X-shaped pattern, which we call an X-alignment. The key feature of these alignments is that they have symmetry around the replication origin and terminus; that is, the distance of a particular conserved feature (DNA or protein) from the replication origin (or terminus) is conserved between closely related pairs of species. Statistically significant X-alignments are also found within some genomes, indicating that there is symmetry about the replication origin for paralogous features as well. The most likely mechanism of generation of X-alignments involves large chromosomal inversions that reverse the genomic sequence symmetrically around the origin of replication. The finding of these X-alignments between many pairs of species suggests that chromosomal inversions around the origin are a common feature of bacterial genome evolution.
Abstract P075: Prevalence and Characterization of Sleep Disordered Breathing in Heart Failure Patients
Authors: Zunera Ghaznavi, Alberta Warner, Armand Ryden, Dale Jun, Michelle Zeidler
Journal: Circulation (2015)

Introduction: There is increasing evidence that sleep-disordered breathing (SDB) plays a significant role in progression of heart failure (HF) and increased risk of mortality, yet it remains underdiagnosed among HF patients. Retrospective studies suggest that the prevalence of SDB among patients with HF is approximately 50%, with more than 40% having central sleep apnea (CSA) and about 27% having obstructive sleep apnea (OSA). Few studies have prospectively evaluated the prevalence of SDB in a cohort of patients recently hospitalized for heart failure. Hypothesis: Prevalence of SDB among patients with a recent HF hospitalization is greater than 50% and that greater than 40% will have CSA. Methods: Patients hospitalized with a primary diagnosis of HF were enrolled. Diagnosis was verified using elevated B-type natruietic peptide, Framingham criteria, and validated by a cardiologist. Subjects completed standard sleep questionnaires and underwent ambulatory sleep tests. Overnight polysomonography (PSG) was re...
Surgeons perform Germany's first crossover kidney transplantation
Authors: Tuffs Annette
Journal: BMJ (2005)

German surgeons have carried out the country's first crossover kidney transplantation at transplant centres in Hamburg and Essen, after a court ruling making the procedure legal in certain circumstances.

Crossover transplants are used in some countries, such as Switzerland and Romania, when a healthy partner in a couple is unable to donate his or her kidney to the spouse, either because of blood group incompatibility or the potential recipient's sensitisation to certain antibodies. In a crossover transplantation a healthy person in one couple donates his or her kidney to the ill person in another couple, in exchange for a kidney from the recipient's healthy spouse.

In the past crossover transplantation was not done in Germany because it was considered illegal under the …