tbuckley/cabot-search huggingface dataset:
Advanced Lipoprotein Testing in Young Adults
Authors: Paul Ziajka
Journal: Annals of Internal Medicine (2005)

Letters15 November 2005Advanced Lipoprotein Testing in Young AdultsPaul Ziajka, MD, PhDPaul Ziajka, MD, PhDFrom The Florida Lipid Institute, Winter Park, FL 32792.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-143-10-200511150-00019 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:I would like to make 4 comments regarding the article by Tzou and colleagues (1) on advanced lipoprotein testing. First, the paper is of historical interest but I am concerned that the study's conclusions will be applied to contemporary medical practice. It is important to remember that these investigators analyzed 9- to 10-year-old data by using 9- to 10-year-old technologies. The ultrasound device used in this study to assess carotid intima–media thickness (IMT) had an absolute value of repeated measure differences of 0.06 mm and an intraclass correlation of 0.55 for the composite carotid IMT. More recent ...References1. Tzou WS, Douglas PS, Srinivasan SR, Chen W, Berenson G, Stein JH. Advanced lipoprotein testing does not improve identification of subclinical atherosclerosis in young adults: the Bogalusa Heart Study. Ann Intern Med. 2005;142:742-50. [PMID: 15867406] LinkGoogle Scholar2. Oren A, Vos LE, Uiterwaal CS, Grobbee DE, Bots ML. Cardiovascular risk factors and increased carotid intima-media thickness in healthy young adults: the Atherosclerosis Risk in Young Adults (ARYA) Study. Arch Intern Med. 2003;163:1787-92. [PMID: 12912713] CrossrefMedlineGoogle Scholar3. Kulkarni KR, Garber DW, Marcovina SM, Segrest JP. Quantification of cholesterol in all lipoprotein classes by the VAP-II method. J Lipid Res. 1994;35:159-68. [PMID: 8138718] CrossrefMedlineGoogle Scholar Author, Article, and Disclosure InformationAuthors: Paul Ziajka, MD, PhDAffiliations: From The Florida Lipid Institute, Winter Park, FL 32792.Disclosures: Employment: P. Ziajka (Atherotech). PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoAdvanced Lipoprotein Testing Does Not Improve Identification of Subclinical Atherosclerosis in Young Adults: The Bogalusa Heart Study Wendy S. Tzou , Pamela S. Douglas , Sathanur R. Srinivasan , Wei Chen , Gerald Berenson , and James H. Stein Advanced Lipoprotein Testing in Young Adults Wendy S. Tzou and James H. Stein Metrics 15 November 2005Volume 143, Issue 10Page: 756-757KeywordsAtherosclerosisAttentionCholesterolLipidsLipoproteinsLongitudinal studiesPhenotypesUltrasound imagingYoung adults ePublished: 15 November 2005 Issue Published: 15 November 2005 Copyright & PermissionsCopyright © 2005 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Identification of Gulf War Syndrome: Methodological Issues and Medical Illnesses
Authors: Zhongren Jing
Journal: JAMA (1997)

<h3>To the Editor.</h3> —Although Dr Haley and coinvestigators<sup>1</sup>have made a valiant attempt to define Gulf War-related syndromes among Gulf War veterans, a key methodological limitation of their study is the inability to support a link between service in the Gulf War and the syndromes that were uncovered. To conclude that syndromes are related to service in the Gulf War because they are found among Gulf War veterans is premature. The possibility that the same methods applied to a sample of nondeployed, Gulf War-era veterans would find a similar proportion of veterans reporting the same syndromes cannot be excluded. The authors note their sample consists of healthy and ill Gulf War veterans. However, to link syndromes to Gulf War service, this distribution of subjects cannot substitute for a non-Gulf War veteran control group. Similarly, observing relationships among exposures reported by veterans, clinically derived case criteria, or biological factors cannot substitute for an
Abstract 1338: MicroRNAs in a mouse model of oral carcinogenesis
Authors: Xiao-Han Tang, Lorraine Gudas
Journal: Cancer Research (2011)

Abstract MicroRNAs (miRNAs) can function as oncogenes or tumor suppressor genes. Aberrant expression of microRNAs has been reported in human tongue squamous carcinoma cells. In this study, we investigated the effects of the carcinogen, 4-nitroquinoline 1-oxide (4-NQO), on the expression of several miRNAs in mouse tongues by using a seminal mouse model of oral carcinogenesis that was established by our laboratory and demonstrates similarities to human oral tumors in terms of morphological, histopathological, and molecular characteristics. In addition, we studied the effects of the DNA methyltransferase (Dnmt) inhibitor 5-Aza-2′-deoxycytidine (5-Aza, 0.25 mg/kg body weight), all-trans retinoic acid (RA, given at 100 μg/kg body weight and 1 mg/kg body weight, respectively), and the combination of 5-Aza and the low dose RA on murine oral cavity carcinogenesis induced by 4-NQO and on mouse tongue miRNA expression levels in this mouse model. Compared with control mice (not treated with 4-NQO), 4-NQO treatment caused a remarked reduction in the expression of miR-26a and miR-124a in mouse tongues and an increase in CDK2 (one of miR-124a's targets) mRNA expression. Among all drug treatments, the combination of 5-Aza and the low dose RA attenuated the reduction in the expression of miR-124a caused by the 4-NQO treatment. To some extent, mice in all drug treatment groups showed a reduction in the degree of decrease in the expression of miR-26a in mouse tongues induced by 4-NQO. These results correlate with the data on neoplastic tongue lesion numbers and tongue lesion severity. Moreover, we found that RA, 5-Aza, and the combination of RA and 5-Aza all enhanced the expression of miR-26a and miR-124a in a human tongue squamous cell carcinoma cell line, SCC-15, and that the combination of RA and 5-Aza had the greatest effects. Collectively, our results show that miRNAs have potential as a strategy to reduce oral cavity cancer. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 102nd Annual Meeting of the American Association for Cancer Research; 2011 Apr 2-6; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2011;71(8 Suppl):Abstract nr 1338. doi:10.1158/1538-7445.AM2011-1338
TREATMENT OF MALIGNANT DISEASE BY PITUITRIN AND THEELIN
Authors: W. Stewart
Journal: BMJ (1932)

URINARY " PROTEOSE " IN IDIOPATHIC EPILEPSY TMJTsBRITTIR " proteose "-injected arm than in the control arm.The only interesting fact that emerged was that one of the injected patients developed a severe urticarial rash the next day, which, it was considered at the time, might be due to a sensitivity towards the injected " proteose."A week later the same ten cases were taken and again injected, this time with a different " proteose."Five were injected intradermally with 0.1 c.cm. of a 1 in 1,000 solution of a " proteose " obtained from another epileptic, two were injected with a similar volume of a " proteose " obtained from the urine of an asthmatic, and three with a " proteose " from a case of migraine, the last solutions being kindly supplied by Dr. E. N. Davey, the pathologist to the Gloucestershire Royal Infirnmary.At the same time three normal healthy persons were injected with a similar amount of epileptic " proteose."Again no reaction was produced in any of those injected.At the end of another week a further series of injections were given, using a 1 in 100 solution, but with these again no reaction indicating sensitivity was produced.
Guidelines for Treatment of Pediatric Asthma—Reply
Authors: Mike Mitka
Journal: JAMA (2008)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
A Variant of AESOP Syndrome (Adenopathy and Extensive Skin Patch Overlying a Plasmacytoma)—Reply
Authors: Chong Wee Foo, Scott R. Florell, Marta J. Petersen
Journal: JAMA Dermatology (2013)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Dermatology HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Dermatology journal
Multiple bronchial stenoses: treatment by mechanical dilatation.
Authors: P B Iles
Journal: Thorax (1981)

Four patients with multiple bronchial stenoses are described. Two patients had pulmonary sarcoidosis, the third probably had berylliosis, and the aetiology in unknown in the fourth. Their symptoms included dyspnoea, wheeze, stridor, and frequent chest infections. The bronchial stenoses were demonstrated by tomography, flow volume studies, and bronchoscopy. Corticosteroids were ineffective but improvement followed bougie dilatation at rigid bronchoscopy.
Anti-Inflammatory Effect of Obstructive Jaundice in Rats
Authors: R. L. Engerman, R. K. Meyer
Journal: Annals of the Rheumatic Diseases (1959)

Detailed clinical observations by Hench (1933, 1934) established that hepatogenous jaundice ameliorated rheumatoid arthritis and fibrositis.Reports followed of remissions attending jaundice induced by the injection of bile salts and bilirubin (Thompson and Wyatt, 1938), by inoculation with infectious jaundice (Gardner, Stewart, and Mac- Callum, 1945), and by lactophenin (Hanssen, 1942), in addition to the many remissions attributed to cinchophen toxic hepatitis.In rats also, jaundice caused by the ligation of the bile duct inhibited an experimental arthritis produced by the injection of formalin (Selye, 1950) or of pleuropneumonia-like organisms (Snow and Hines, 1941).Selye's inter- pretation of jaundice and arthritis in terms of stress and inflammatory processes suggested that the anti- inflammatory effect of jaundice might be mediated by a hypersecretion of adrenal glucocorticoids (Selye, 1950).Subsequently, Selye (1954) provided evidence that an increased secretion of glucocorticoids is not prerequisite to a reduction of inflam- matory processes during jaundice.He found that jaundice enhanced the anti-inflammatory effect of cortisone in adrenalectomized rats, and interpreted this as being due to a glucocorticoid-sensitizing principle in jaundice.A possibility that jaundice inhibited the inactivation of glucocorticoids was investigated by Baker (1955), and liver slices from jaundiced and non-jaundiced rats were found to inactivate equal amounts of hydrocortisone.The present study was undertaken to obtain additional information about the role of adrenocortical hormones in inflammatory processes during obstructive jaundice.Indices of adrenocortical
The Treatment of Acute Pancreatitis: A Continuing Challenge
Authors: Carlos A. Pellegrini
Journal: New England Journal of Medicine (1985)

Most patients with acute pancreatitis recover rapidly and completely, regardless of the cause or the treatment, but in 5 to 15 per cent of patients the disease takes a fulminant course. Of these patients, 20 to 60 per cent either die or face life-threatening complications. Ranson and colleagues1 defined 11 clinical criteria that correlate with the severity of acute pancreatitis, including such features as the white-cell count, a decrease in the hematocrit, and a reduction in serum calcium. Using these criteria, one can identify most patients who will have an unsatisfactory outcome. After an initial assessment based on the Ranson . . .
Inhibition of cytoplasmic and organellar protein synthesis in Toxoplasma gondii. Implications for the target of macrolide antibiotics.
Authors: C J Beckers, D S Roos, R G Donald, B J Luft, J C Schwab, Y Cao, K A Joiner
Journal: Journal of Clinical Investigation (1995)

We investigated potential targets for the activity of protein synthesis inhibitors against the protozoan parasite Toxoplasma gondii. Although nanomolar concentrations of azithromycin and clindamycin prevent replication of T. gondii in both cell culture and in vivo assays, no inhibition of protein labeling was observed in either extracellular or intracellular parasites treated with up to 100 microM drug for up to 24 h. Quantitative analysis of > 300 individual spots on two-dimensional gels revealed no proteins selectively depleted by 100 microM azithromycin. In contrast, cycloheximide inhibited protein synthesis in a dose-dependent manner. Nucleotide sequence analysis of the peptidyl transferase region from genes encoding the large subunit of the parasite's ribosomal RNA predict that the cytoplasmic ribosomes of T. gondii, like other eukaryotic ribosomes, should be resistant to macrolide antibiotics. Combining cycloheximide treatment with two-dimensional gel analysis revealed a small subset of parasite proteins likely to be synthesized on mitochondrial ribosomes. Synthesis of these proteins was inhibited by 100 microM tetracycline, but not by 100 microM azithromycin or clindamycin. Ribosomal DNA sequences believed to be derived from the T. gondii mitochondrial genome predict macrolide/lincosamide resistance. PCR amplification of total T. gondii DNA identified an additional class of prokaryotic-type ribosomal genes, similar to the plastid-like ribosomal genes of the Plasmodium falciparum. Ribosomes encoded by these genes are predicted to be sensitive to the lincosamide/macrolide class of antibiotics, and may serve as the functional target for azithromycin, clindamycin, and other protein synthesis inhibitors in Toxoplasma and related parasites.
AN IMPROVED METHOD FOR THE DETERMINATION OF WATER BALANCE 1
Authors: F. H. Wiley, L. H. Newburgh
Journal: Journal of Clinical Investigation (1931)

An earlier publication from this laboratory (1) dealt with the meas- urement of total water exchange.In the interval, the application of this method has given rise to a number of modifications which increase the accuracy of the results obtained, so that it appears advisable to discuss the subject again.In a recent article (2), we have shown that the method of Benedict and Root (3) for the estimation of basal heat production from the in- sensible loss of weight, is subject to rather large errors.On the other hand, we have pointed out (4) that the determination of the amount of water vaporized in twenty-four hours gives an accurate method for estimating the total energy exchange in individuals under conditions of normal activity.This paper will deal with the water balance in one of these individuals on two different diets, since this data is well suited for the discussion of the principles involved.A portion of the data of this experiment is being reported in another publication (5).The estimation of water balance necessitates the direct determination, or the calculation of, four sources of water to the organism, and of three means of excretion of water from it.The factors involved in water balance may be advantageously listed as follows:Excretory water Sources of water 1.Water of urine. 4. Water of food. 2. Water of stool.5. Water drunk.3. Insensible water 6.Water of oxidation. 7. Preformed water.
Case 16-1961
Authors: Richard C. Cabot, Benjamin Castleman, Betty U. Kibbee
Journal: New England Journal of Medicine (1961)

Presentation of Case A thirty-eight-year-old man was admitted to the hospital because of diarrhea. During the four years before entry there were four or five episodes of diarrhea, each persisting for two or three weeks except for the most recent episode, which lasted for about ten weeks. During these episodes the patient passed five or six loose or watery stools daily, including nightly bowel movements. There was no blood or mucus or associated vomiting. Abdominal pain rarely occurred. He lost 14 pounds in weight and was weak. Iodoquin therapy afforded no relief, although he believed that it had occasionally been . . .
Residents' Work Schedules-Reply
Authors: Timothy B. McCall
Journal: JAMA (1989)

<h3>In Reply. —</h3> Drs Gleckel and Walerstein complain about my advocacy of "untested guidelines" such as those promulgated by the Bell Committee. But where are the scientific studies supporting the present residency training system? Despite decades of opportunity, not a single study has shown that 100-hour work weeks or 36-hour shifts improve patient care or result in a better educational experience. I find it hypocritical for those who tolerated an obviously flawed residency system—that lacked any scientific underpining—now to demand studies before making changes. I do support trials of innovative training programs. What I oppose is delaying overdue changes for several more years to acquire data. As I have discussed elsewhere,<sup>1</sup>the present system is suboptimal for learning. Although its supposed educational advantages often are used to defend it, according to Wentz and Ford,<sup>2</sup>the "evolution of many... characteristics has been determined more by socioeconomic-political issues than by
Effect of chemotherapy on the larval mass and the long-term course of alveolar echinococcosis
Authors: Rudolf W. Ammann, Nicolas Ilitsch, Borut Marincek, Andreas U. Freiburghaus
Journal: Hepatology (1994)

The efficacy of long-term chemotherapy in nonresectable alveolar echinococcosis is debated, particularly because of the difficulty in defining therapeutic success. In this study the effect of chemotherapy on the parasitic mass was evaluated in a series of 37 patients. The patients had larval lesions documented by serial computed tomography studies at least 1.5 yr after chemotherapy (mean = 6.4 yr, range = 1.5 to 10.7 yr). The therapeutic regimen consisted of mebendazole (n = 34) or albendazole (n = 3) as previously described. The maximal areas of the parasitic lesions were assessed morphometrically by means of digital image analysis, utilizing the point-integration method, before and after chemotherapy. Marked regression of larval tissue occurred in 18 patients (group A; 48.6%), stationary lesions were noted in 13 patients (group C; 35.1%) and progression was found in 6 patients (group B; 16.2%). The three groups did not differ significantly with regard to age, plasma drug levels, duration of chemotherapy or initial size and composition of lesions (e.g., cystic cavities, degree of calcification). Despite morphologically successful chemotherapy in most patients (e.g., 84%; groups A and C), late cholestatic complications after 1.5 to 11 yr of chemotherapy occurred in 10 patients (group A, n = 7; group C, n = 3; 4 of them died) and esophageal variceal bleeding occurred in 3 patients (relieved by sclerotherapy). These late complications were probably mainly due to posttherapy fibrosis of hilar structures. In conclusion, our data support the efficacy of chemotherapy. However, chemotherapy is not curative, and severe late complications were observed in patients with hilar (fibrotic) involvement. (Hepatology 1994;19:735-742).
Increased F-18 FDG Uptake in Resolving Atraumatic Bilateral Adrenal Hemorrhage (Hematoma) on PET/CT
Authors: Brandon M. Repko, Mark Tulchinsky
Journal: Clinical Nuclear Medicine (2008)

A 61-year-old woman developed atraumatic bilateral adrenal hemorrhages while on anticoagulation. CT and MRI scans demonstrated enlarged adrenals with typical hemorrhagic features. Sequential CT scans showed gradual resolution of adrenal enlargement. Four months after the bleed, PET/CT was done and showed intense focal F-18 fluoro-2-deoxy-D-glucose (FDG) uptake in both adrenal glands. Malignancy and infection are often at the top of the differential for increased adrenal FDG uptake. Follow-up confirmed that abnormal FDG uptake in this case was secondary to resolving adrenal hemorrhage. This diagnosis should be considered in an appropriate imaging setting when adrenal glands demonstrate increased FDG uptake.
Abstract P1-09-06: Breast cancer in the Pan-American region: Inequities in incidence and mortality rates according to the human development index
Authors: CH Barrios, G Werutsky, J Martínez-Mesa
Journal: Cancer Research (2013)

Abstract Background: Breast cancer (BC) is considered a public health problem in countries of the Pan-American Health Organization (PAHO). Data from GLOBOCAN 2008 shows BC age-adjusted incidence and mortality rates of 57.1 and 13.7 per 100,000 inhabitants in the region. The aim of the present study is to evaluate the association between BC incidence and mortality rates with the human development index (HDI) in PAHO countries. Methods: This is an ecological analysis including 29 countries (PAHO) with reported data both in GLOBOCAN 2008 and in the 2013 United Nation Development Reports (UNDP). In alphabetical order the participant countries were Argentina, Bahamas, Barbados, Belize, Bolivia, Brazil, Canada, Chile, Colombia, Costa Rica, Cuba, Dominican Republic, Ecuador, El Salvador, Guatemala, Guyana, Haiti, Honduras, Jamaica, Mexico, Nicaragua, Panama, Paraguay, Peru, Suriname, Trinidad and Tobago, United States of America, Uruguay and Venezuela. HDI is a composite statistic of life expectancy, education, and income and was analyzed as a continuous score. Age-adjusted BC incidence and mortality rates were taken from GLOBOCAN 2008 and log-transformed due to skewness. Pearson correlation and simple linear regression were performed using Stata 12 (Stata Corp., College Station, USA). Results: A positive correlation was found between HDI and log-transformed age-adjusted BC incidence and mortality rates. The correlation coefficient between HDI and BC incidence rate was 0.68 (p-value&amp;lt;0.001). The correlation with BC mortality rate was 0.49 (p-value = 0.007). Linear regression showed that an increase in one HDI unit lead to a gain of 3.51 points (se = 0.72; p-value&amp;lt;0.001) in the incidence rate and 2.14 points (se = 0.73; p&amp;lt;0.007) in the mortality rate. Conclusion: HDI inequities are important and should be considered in the analysis of the difference in BC incidence and mortality rates seen in PAHO countries. Citation Information: Cancer Res 2013;73(24 Suppl): Abstract nr P1-09-06.