tbuckley/cabot-search huggingface dataset:
HICCUP AS A COMPLICATION OF ACUTE CORONARY ARTERY OCCLUSION
Authors: Morris M. Weiss
Journal: Annals of Internal Medicine (1939)

Case Reports1 July 1939HICCUP AS A COMPLICATION OF ACUTE CORONARY ARTERY OCCLUSIONMORRIS M. WEISS, M.D., F.A.C.P.MORRIS M. WEISS, M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-13-1-187 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptHiccup as a complication of an acute coronary artery occlusion is not mentioned in the literature. In the past year I have encountered this annoying and distressing symptom in three cases. In one patient the hiccups commenced about four hours after the onset of the painful features of the occlusion and lasted with varying severity for five days. In the other two cases they appeared on the second day following the occlusion and lasted, also with varying intensity, two and four days respectively. In one patient they ceased suddenly and in the others gradually subsided. Two of the patients had...References1. KATZHAMBURGERSCHUTZ LNWWWJ: Effects of generalized anoxemia on the electrocardiogram of normal subjects. Its bearing on the mechanism of attacks of angina pectoris, Am. Heart Jr., 1934, ix, 771-781. CrossrefGoogle Scholar2. LEVYBARACHBRUENN RLALHG: Effects of induced oxygen want in patients with cardiac pain, Am. Heart Jr., 1938, xv, 187-200. CrossrefGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Louisville, Kentucky*Received for publication May 12, 1938. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byDie Coronarerkrankungen. Coronarinsuffizienz, Angina pectoris und HerzinfarktHiccups Complicating Myocardial Infarction 1 July 1939Volume 13, Issue 1Page: 187-188KeywordsCoronary arteries ePublished: 1 December 2008 Issue Published: 1 July 1939 PDF downloadLoading ...
Researchers Use Dots to Light Up Tumor Cells
Authors: Tracy Hampton
Journal: JAMA (2004)

MUCH LIKE WILDLIFE BIOLOgists studying the comings and goings of animals in nature with devices like radiocollars, cancer investigators would relish in the opportunity to track malignant cells and watch them in action. If they could observe how tumor cells grow and spread, they might be able to come up with effective treatment strategies. Now researchers are able to see the minute-by-minute activities of cancer cells, thanks to a new technology that uses fluorescent inorganic nanocrystals that glow under UV light. Two new studies highlight the utility of these tiny particles, called quantum dots.
Abstract 2633: TP53 loss creates therapeutic vulnerability in cancer
Authors: Yunhua Liu, Xiongbin Lu
Journal: Cancer Research (2014)

Abstract TP53, a well-known tumor suppressor gene, is frequently inactivated by mutation or deletion in a majority of human tumors. Theoretically, targeting the p53 pathway would lead to successful anti-cancer treatments. However, no effective p53-based anti-cancer therapy has been developed due to the complexity of the p53 regulators and their poor drugability. Here we demonstrate that focal deletion of TP53 often encompasses neighboring essential genes, rendering cancer cells with hemizygous p53 deletion highly vulnerable to further suppression of such genes. One such gene, POLR2A, encodes the largest subunit of RNA polymerase II complex. We found that its expression correlates with copy number changes and suppression of POLR2A with its inhibitors, alpha-amanitin or short-hairpin RNA, selectively inhibits growth, survival and tumorigenic potential in colon cancer cells with hemizygous TP53 loss, suggesting an novel and effective strategy for cancers with such genomic alternations. Note: This abstract was not presented at the meeting. Citation Format: Yunhua Liu, Xiongbin Lu. TP53 loss creates therapeutic vulnerability in cancer. [abstract]. In: Proceedings of the 105th Annual Meeting of the American Association for Cancer Research; 2014 Apr 5-9; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2014;74(19 Suppl):Abstract nr 2633. doi:10.1158/1538-7445.AM2014-2633
713. Gene Correction Therapy Using Designed Zinc Finger-Based Endonucleases
Authors: Michael C. Holmes, Fyodor D. Urnov, Ya-Li Lee, Jeffrey C. Miller, Philip D. Gregory
Journal: Molecular Therapy (2004)

Human monogenic disorders, such as X-linked SCID, cystic fibrosis, sickle cell anemia, and hemophilia, are caused by hypomorphic or null mutations in a single gene, and restoration of even a single wild-type allele in a sub-population of cells can be curative. In practice, however, resistance to homologous recombination (HR) is a universal feature of mammalian genomes. An important exception to this rule occurs during repair of double-strand breaks (DSBs), which are healed by  conversion – a unidirectional transfer of genetic information missing at the break from a homologous sequence such as a sister chromatid. Extensive analysis with reporter genes engineered to contain recognition sites for rare endonucleases validated the notion that a DSB potentiates homologous recombination by several orders of magnitude. The concept of targeted DSB-driven genome editing can be expanded from reporter genes to any endogenous locus via the use of zinc finger protein-based chimeric endonucleases (ZFNs): enzymes whose DNA cleavage specificity is determined by a designed zinc finger protein, engineered to bind specifically to a sequence at the mutated locus. We present data on the use of such ZFNs to introduce defined nucleotide changes at several endogenous loci in the human genome, including the IL2Rg and b-globin loci. Use of such   in the context of the clinic will require high-frequency targeting. We present data on optimization of the targeting protocol that reproducibly yields > 10' gene-targeted cells in a given population in the absence of any selective pressure. This approach to gene correction could be used to treat monogenic disorders such as X-linked SCID and Sickle Cell Anemia.
The kidney plays a major role in the hyperammonemia seen after simulated or actual GI bleeding in patients with cirrhosis
Authors: Steven W.M. Olde Damink, Rajiv Jalan, Nicolaas E.P. Deutz, Doris N. Redhead, Cornelis H.C. Dejong, Paula Hynd, Rosy A. Jalan, Peter C. Hayes, Peter B. Soeters
Journal: Hepatology (2003)

Upper gastrointestinal (UGI) bleeding in cirrhosis is associated with enhanced ammoniagenesis, the site of which is thought to be the colon. The aims of this study were to evaluate interorgan metabolism of ammonia following an UGI bleed in patients with cirrhosis. Study 1: UGI bleed was simulated in 8 patients with cirrhosis and a transjugular intrahepatic portasystemic stent–shunt (TIPSS) by intragastric infusion of an amino acid solution that mimics the hemoglobin molecule. We sampled blood from the femoral artery and a femoral, renal, portal, and hepatic vein for 4 hours during the simulated bleed and measured plasma flows across these organs. Study 2: In 9 cirrhotic patients with an acute UGI bleed that underwent TIPSS insertion, blood was sampled from an artery and a hepatic, renal, and portal vein, and plasma flows were measured. Study 1: During the simulated bleed, arterial concentrations of ammonia increased significantly ( P = .002). There was no change in ammonia production from the portal drained viscera, but renal ammonia production increased 6–fold ( P = .008). In contrast to an unchanged ammonia removal by the liver, a significant increase in muscle ammonia removal was observed. Study 2: In patients with an acute UGI bleed, ammonia was only produced by the kidneys (572 [184] nmol/kg bw/min) and not by the splanchnic area (-121 [87] nmol/kg bw/min). In conclusion, enhanced renal ammonia release has an important role in the hyperammonemia that follows an UGI bleed in patients with cirrhosis. During this hyperammonemic state, muscle is the major site of ammonia removal.
Abstract 851: Characteristics of adult men who are willing to give HPV vaccine to their daughters in the United States: a national survey
Authors: Jessica Rogers, Kolapo A. Idowu, Rahmatalai Coker, Hamidat Segunmaru, Mohammad Daremipouran, Clinton Burnside, Carla D. Williams, Adeyinka O. Laiyemo
Journal: Cancer Research (2015)

Abstract Background: The uptake of Human Papillomavirus (HPV) vaccination needs improvement. However, efforts to improve uptake of HPV vaccine is often concentrated on women. Although men can influence the uptake of the vaccine by their children, the opinion of adult men in the United States on HPV vaccination has not been well studied. Aim: To evaluate the willingness of adult men to vaccinate their daughters for HPV Methods: Health Information National Trends Survey (HINTS) 2007 was used to capture the opinion of 1,927 men (weighted population size = 72,633,670) who answered questions on their willingness to let their daughters receive HPV vaccine. We compared the characteristics of those who were willing to let their daughters receive HPV vaccine with those who were not. We used survey weights in all analyses, and variance estimations were performed using Taylor series linearization to account for the complex survey design. We used logistic regression models to calculate odds ratios (OR) and 95% confidence intervals (CI). Results: A total of 1,554 (80.7%) men were willing to let their daughters receive HPV vaccine while 373 (19.3%) would not let their daughters receive the vaccine. The most common reasons for disagreeing with vaccination were: not knowing enough about it (27.7%); vaccine safety concerns (16.5%); and “my child is not sexually active” (13.7%). Of note, less than 1% felt the vaccine will promote promiscuity. Demographic (age, race, marital status, education status, and health insurance) and lifestyle characteristics (smoking and body mass index) did not predict men who would let their daughters get HPV vaccine. Conclusion: A high percentage of men are willing to let their daughters receive HPV vaccine suggesting that all men should be engaged in the conversation to improve HPV vaccine uptake in the United States. Primary care physicians should make it a priority to discuss the HPV vaccine with men and women more frequently to enlighten the population and allay their fears about the safety of the vaccine. Citation Format: Jessica Rogers, Kolapo A. Idowu, Rahmatalai Coker, Hamidat Segunmaru, Mohammad Daremipouran, Clinton Burnside, Carla D. Williams, Adeyinka O. Laiyemo. Characteristics of adult men who are willing to give HPV vaccine to their daughters in the United States: a national survey. [abstract]. In: Proceedings of the 106th Annual Meeting of the American Association for Cancer Research; 2015 Apr 18-22; Philadelphia, PA. Philadelphia (PA): AACR; Cancer Res 2015;75(15 Suppl):Abstract nr 851. doi:10.1158/1538-7445.AM2015-851
THE HEART RATE IN MALARIA; A REVIEW OF NINETY CASES
Authors: Sherman M. Mellinkoff, John R. Higgins
Journal: Annals of Internal Medicine (1947)

Article1 September 1947THE HEART RATE IN MALARIA; A REVIEW OF NINETY CASESSHERMAN M. MELLINKOFF, JOHN R. HIGGINSSHERMAN M. MELLINKOFFSearch for more papers by this author, JOHN R. HIGGINSSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-27-3-433 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptMost textbooks state that the typical malaria patient exhibits chills, fever, and tachycardia.1, 2, 3, 4, 5This clinical triad is frequently helpful in the differential diagnosis that runs through the physician's mind when he first sees a patient in a malarious zone. Among army personnel in certain regions of Asia, for example, it is common to see an acutely ill, prostrated man with chills and fever, while the physical examination gives no clue to the diagnosis except the heart rate. On the basis of probability in this particular locality, when there is a relative bradycardia one thinks of the...Bibliography1. STRONG R: Stitt's Diagnosis, prevention and treatment of tropical diseases, 1944, Blakiston Co., Philadelphia, pages 67 and 77. Google Scholar2. NAPIER LE: The principles and practice of tropical medicine, 1946, Macmillan Co., page 81. Google Scholar3. MANSON-BAHR PH: Tropical diseases, 1945, Cassell and Co., Ltd., London, page 67. Google Scholar4. MACKIEHUNTERWORTH TTGWCB: Manual of tropical medicine, 1945, W. B. Saunders Co., Philadelphia, page 243. Google Scholar5. CRAIGFAUST CFEC: Clinical parasitology, 1940, Lea and Febiger, Philadelphia, page 206. Google Scholar6. JONES AN: Malignant malaria on the gold coast, Ann. Trop. Med., 1944, xxxviii, 2. Google Scholar7. NOEHREN TH: The malaria triad, Ann. Int. Med., 1946, xxiv, 299. Google Scholar8. HYMAN AS: Clinical masquerades of malaria, U. S. Nav. Med. Bull., 1945, xlv, 297. Google Scholar9. HUGHESBOMFORD SBRR: Clinical features and treatment of malaria in British troops in West Africa, Brit. Med. Jr., 1944, i, 71. Google Scholar10. The War Office Memoranda on Medical Diseases in Tropical and Subtropical Areas, 1942, Chemical Publishing Co., London. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: *Received for publication November 22, 1946. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byTrajectories of the heart rate characteristics index, a physiomarker of sepsis in premature infants, predict Neonatal ICU mortalityPathologic physiology and chemotherapy of Plasmodium berghei 1 September 1947Volume 27, Issue 3Page: 433-440KeywordsArmed forcesBradycardiaFeversHeart rateMalaria ePublished: 1 December 2008 Issue Published: 1 September 1947 PDF downloadLoading ...
Clinical and pharmacy-economical reasonability of the choice of fixed combination of fluticasone/salmeterol in the curing of bronchial asthma in the country with limited financing of the public health
Authors: Dmitry Ruzanov, Elena Davidovskaya, Tatyana Baranovskaya
Journal: European Respiratory Journal (2011)

Aim:  To estimate the real practice of prescription of preparations in curing BA, to analyze clinical and pharma-economical efficiency of conversion to the fixed combination of SALM/FP in curing BA.   Method:  The real practice of curing 266 patients with separated using of different preparations of basic therapy and short-rated broncholitics was retrospectively analyzed during the year (1st period) and the following year of their using of SALM/FP (2nd period).   Results:  It was managed to attain control (ACT) of 15,5% of patients in the real practice (1st period). System glucocorticoids were ambulatorially prescripted to 41 patient. On the average each patient used 15,6 inhaler SABA. The cost of treatment (ambulance, hospitalization, medicines, visits of the doctor, social payment) came to 1405 EUR per year.  Controlled BA (at the end of the observation year) was recorded among 74,3% of patients during the 2nd period. The prescriptions of auxiliary medicines were cut by 6,4 times, the frequency of ambulance by 16,8 times, the duration of hospitalization by 11,7 times. On the average each patient used 0,78 of inhaler SABA. The cost of treatment came to 892 EUR per year. Typical errors of treatment have been analysed.   Conclusion:  The real clinical practice of curing BA in RB often differs from the recommendations of GINA 2009 and leads to the low level of control of BA (among 15,5%). The conversion to using fixed combination of SALM/FP enables to increase the percentage of patients with controlled asthma to 74,3% and cut the cost of treatment by 1,6 times.
Augmented production of soluble CD93 in patients with systemic sclerosis and clinical association with severity of skin sclerosis
Authors: K. Yanaba, Y. Asano, S. Noda, K. Akamata, N. Aozasa, T. Taniguchi, T. Takahashi, Y. Ichimura, T. Toyama, H. Sumida, Y. Kuwano, Y. Tada, M. Sugaya, T. Kadono, S. Sato
Journal: British Journal of Dermatology (2012)

Background The cell surface protein CD93, expressed on endothelial and myeloid cells, mediates phagocytosis, inflammation and cell adhesion. A soluble form of CD93 (sCD93) is released during inflammation. Objectives To determine the serum sCD93 level and its association with clinical parameters in patients with systemic sclerosis (SSc). Methods Serum sCD93 levels were examined by enzyme-linked immunosorbent assay in 59 patients with SSc, 24 patients with systemic lupus erythematosus and 47 healthy individuals. The expression of CD93 in skin tissues was examined immunohistochemically. In a retrospective longitudinal study, sera from 11 patients with SSc were analysed. Results Serum sCD93 levels were increased in patients with SSc compared with healthy individuals (P < 0·001). Patients with diffuse cutaneous SSc showed greater levels of sCD93 than those with limited cutaneous SSc (P < 0·01) or systemic lupus erythematosus (P < 0·01). Serum sCD93 levels correlated positively with the severity of skin sclerosis. Strong CD93 immunostaining was observed on endothelial cells in lesional skin tissues. In the longitudinal study, sCD93 levels decreased in parallel with improvement in skin sclerosis. Conclusions Serum sCD93 levels are increased in patients with SSc and correlate with the severity and activity of skin sclerosis. CD93 may contribute to the development of skin fibrosis in SSc.
MEDICINE AND EDUCATION
Authors: E E IRONS
Journal: Annals of Internal Medicine (1946)

Article1 August 1946MEDICINE AND EDUCATIONERNEST E. IRONS, F.A.C.P.ERNEST E. IRONS, F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-25-2-228 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptEducation has been described as the "taking on of the arts and sciences and of moral attitudes which make up the fabric of civilization." In this process, educated people acquire an appreciation of values, the ability to think and to see the relations of the values to each other in human living. Unfortunately, as George Vincent put it, many people do not think; they merely rearrange their prejudices. The Harvard report well states the general problem. "The aim of education should be to prepare an individual to become an expert both in some particular vocation or art and in the... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Chicago, Illinois*Presidential Address, Victory Convocation, Twenty-Seventh Annual Session, American College of Physicians, Philadelphia, May 15, 1946. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byRecent Advances in the Knowledge of “Virus Hepatitis” 1 August 1946Volume 25, Issue 2Page: 228-235 ePublished: 1 December 2008 Issue Published: 1 August 1946 PDF downloadLoading ...
Researchers Coax Human Stem Cells to Become Motor Neurons
Authors: Bridget M Kuehn
Journal: JAMA (2005)

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Abstract 3075: Midwall Fractional Shortening and Circumferential End- Systolic Wall Stress in Morbidly Obese Patients Before and After Bariatric Surgery
Authors: Maria Luaces, Ivan J Nunez-Gil, Rosa M Jimenez-Hernandez, Paula Awamleh, Pedro Talavera-Calle, Manuel Medina, Azucena Rodriguez-Robles, Joaquin J Alonso-Martin
Journal: Circulation (2009)

Introduction . Adaptative cardiac changes in morbidly obese patients frequently involve abnormalities in the left ventricular geometric pattern, including hypertrophy and modified left ventricular sphericity properties. Midwall measurement of LV systolic function may be preferable to endocardial measurements in these patients.   Objective . To assess the parameters of midwall LV function in morbidly obese patients accepted for bariatric surgery before and after the procedure.   Methods . Patients accepted for bariatric surgery were prospectively included. In each case, transthoracic echocardiography and measurement of systolic blood pressure following the study were registered before surgery and repeated for follow-up 6 months and 1 year after the procedure. Midwall fractional shortening and circumferential end-systolic wall stress were calculated using their respective equations.   Results . 47 consecutive patients were included. The mean age was 40.4 (10.6) years, and there were 40 women. Follow-up reached 1 year in 24 cases so far. The mean body mass index changed from 46.8 Kg/m 2  before surgery, to 33.9 after 6 months and 30.78 after 1 year, p   Conclusions . Midwall fractional shortening and circumferential end-systolic wall stress are preserved in morbidly obese patients. Systolic blood pressure and relative wall thickness get back to normal values 1 year after bariatric surgery.