THE DILEMMA OF THE NONTOXIC NODULAR GOITER
Authors: William R. Schillhammer, Richard I. Crone
Journal: Annals of Internal Medicine (1956)

Article1 September 1956THE DILEMMA OF THE NONTOXIC NODULAR GOITERWILLIAM R. SCHILLHAMMER, RICHARD I. CRONEWILLIAM R. SCHILLHAMMERSearch for more papers by this author, RICHARD I. CRONESearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-45-3-480 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptPURPOSEThe purpose of this paper is to summarize the experience of some of the major clinics in the United States relative to the frequency of carcinoma of the thyroid in association with nontoxic nodular goiter, and to present a series of cases from a large Army hospital. In addition, we shall attempt to point out the difficulty of interpreting the wealth of material now in print on the subject. The problem of whether the presence of symptoms would render the individual case more likely to have cancer, a facet which has received little attention in the literature, was carefully...Bibliography1. CrileDempsey GWS: Indications for removal of non-toxic nodular goiters, J. A. M. A. 139: 1247, 1949. CrossrefMedlineGoogle Scholar2. HermansonGargillLesses LSLMF: The treatment of nodular goiter, J. Clin. Endocrinol. 12: 112, 1952. CrossrefGoogle Scholar3. ColeMajarakisSlaughter WHJDDP: Incidence of carcinoma of the thyroid in nodular goiter, J. Clin. Endocrinol. 9: 1007, 1949. CrossrefGoogle Scholar4. BeahrsPembertonBlack OHJdBM: Nodular goiter and malignant lesions of the thyroid gland, J. Clin. Endocrinol. 11: 1157, 1951. CrossrefGoogle Scholar5. CeriseRandallOchsner EJSA: Carcinoma of the thyroid and non-toxic nodular goiter, Surgery 31: 552, 1952. MedlineGoogle Scholar6. Ward R: Cancer of the thyroid, California Med. 68: 170, 1948. MedlineGoogle Scholar7. CopeDobynsHamlinHopkirk OBMEJ: What thyroid nodules are to be feared, J. Clin. Endocrinol. 9: 1012, 1949. CrossrefGoogle Scholar8. HornWeltyBrooksRhoadsPendergrass RCRFFPJEEP: Carcinoma of the thyroid, Ann. Surg. 126: 140, 1947. CrossrefGoogle Scholar9. CattellColcock RBBP: The present day problem of cancer of the thyroid, J. Clin. Endocrinol. 13: 1408, 1953. CrossrefGoogle Scholar10. Ward R: Malignant goiter, Surgery 16: 783, 1944. Google Scholar11. LaheyHare FHHF: Malignancy in adenomas of the thyroid, J. A. M. A. 145: 689, 1951. CrossrefMedlineGoogle Scholar12. Colley FA: Adenoma and carcinoma of the thyroid, J. A. M. A. 92: 457, 1929. Google Scholar13. MajarakisSlaughterCole JDDPWH: Carcinoma of the thyroid gland, J. Clin. Endocrinol. 13: 1530, 1953. CrossrefGoogle Scholar14. Crile G: Adenoma and carcinoma of the thyroid gland, New England J. Med. 249: 585, 1953. CrossrefMedlineGoogle Scholar15. Sokol JE: Incidence of malignancy in toxic and non-toxic nodular goiter, J. A. M. A. 154: 1321, 1954. CrossrefMedlineGoogle Scholar16. Sokol JE: Occurrence of thyroid cancer, New England J. Med. 249: 393, 1953. CrossrefMedlineGoogle Scholar17. Miller JM: Carcinoma and thyroid nodules. The problem in an endemic area, New England J. Med. 252: 247, 1955. CrossrefMedlineGoogle Scholar18. MeissnerMcManus WARG: A comparison of the histologic patterns of benign and malignant thyroid tumors, J. Clin. Endocrinol. 12: 1474, 1952. CrossrefGoogle Scholar19. Rice CO: Incidence of nodules in the thyroid, Arch. Surg. 24: 505, 1932. CrossrefGoogle Scholar20. Jaffé RH: The variation in weight of the thyroid gland and the frequency of its abnormal enlargement in the region of Chicago, Arch. Path. 10: 887, 1930. Google Scholar21. SchlesingerGargillSaxe MJSLIH: Studies in nodular goiter, J. A. M. A. 110: 1638, 1938. CrossrefGoogle Scholar22. Helwig CA: The thyroid gland in Kansas, Am. J. Clin. Path. 5: 103, 1935. CrossrefGoogle Scholar23. HazardKaufman JBN: A survey of thyroid glands obtained at autopsy in a so-called goiter area, Am. J. Clin. Path. 22: 860, 1952. CrossrefMedlineGoogle Scholar24. Wegelin C: Die Schilddrüse, in Henke, F., and Lubarsch, O.: Handbuch der speziellen pathologischen Anatomie und Histologie, Vol. 8, 1926, Julius Springer, Berlin. Google Scholar25. VanderGastonDawber JBEATR: Significance of solitary non-toxic thyroid nodules, New England J. Med. 251: 970, 1954. CrossrefMedlineGoogle Scholar26. Vanderlaan WP: The occurrence of carcinoma of the thyroid gland in autopsy material, New England J. Med. 237: 221, 1947. CrossrefMedlineGoogle Scholar27. Crile G: Cancer of the thyroid, J. Clin. Endocrinol. 10: 1152, 1950. CrossrefGoogle Scholar28. BeahrsJudd OHES: Malignant lesions of thyroid gland, S. Clin. North America 31: 1169, 1951. CrossrefMedlineGoogle Scholar29. RogersAsperWilliams WFSPRH: Clinical significance of malignant neoplasms of the thyroid gland, New England J. Med. 237: 569, 1947. CrossrefMedlineGoogle Scholar30. BealScholnickStevens JMGLGA: Incidence of unsuspected cancer in thyroid disease occurring in a nonendemic area, Arch. Surg. 65: 879, 1952. CrossrefGoogle Scholar31. Ravdin RG: Cancer of the thyroid, Am. J. M. Sc. 227: 201, 1954. CrossrefMedlineGoogle Scholar32. PerlmutterSlater MSL: Therapeutic implications of the avidity of solitary thyroid nodules for I131 (Abstract), J. Clin. Endocrinol. 15: 835, 1955. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: *Received for publication February 29, 1956.From the Department of Medicine, Letterman Army Hospital, San Francisco, California.Requests for reprints should be addressed to Major William R. Schillhammer (MC), U. S. Army Hospital, Fort Hood, Texas. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byThe Significance of Nontoxic Thyroid Nodules Final Report of a 15-Year Study of the Incidence of Thyroid MalignancyJOHN B. VANDER, M.D., F.A.C.P., EUGENE A. GASTON, M.D., THOMAS R. DAWBER, M.D., F.A.C.P.Die malignen Schilddrüsentumoren 1 September 1956Volume 45, Issue 3Page: 480-489KeywordsHospital medicineHospitalsThyroidThyroid carcinoma ePublished: 1 December 2008 Issue Published: 1 September 1956 PDF downloadLoading ...