tbuckley/cabot-search huggingface dataset:
Abstract P6-01-15: Expression of high affinity folate receptor in breast cancer brain metastasis
Authors: Jose P Leone, Rohit Bhargava, Adrian Lee, Adam Brufsky
Journal: Cancer Research (2015)

Abstract Background: Folic acid is required by proliferating cells for the synthesis of nucleotide bases among other tasks. The high affinity folate receptor (HFR) is a membrane protein that is upregulated in several cancers of epithelial origin and rarely present in most normal cells. High expression of HFR has been documented in ovarian, breast, kidney, uterine and lung cancers. In breast cancer patients, HFR is overexpressed in 33% of primary tumors (PT) and this is associated with poor prognosis. The HFR expression in breast cancer brain metastases (BCBM) is unknown. The aim of this study was to analyze the incidence of HFR expression in BCBM and its role in the prognosis of this high-risk patient subgroup. Methods: We analyzed a database of 42 patients who underwent craniotomy with resection of breast cancer brain metastasis (BCBM). Of those, we collected 19 brain metastasis (BM) and 13 PT. HFR status was assessed by immunohistochemistry. Log-Rank test analyzed differences in overall survival (OS) between groups. Results: Median age was 51 years (range 24-74). Median follow-up was 4.2 years (range 0.6-18.5). HFR was positive in 4/19 BM (21.1%) and in 1/13 PT (7.7%). Positive samples had low H-scores (range 1-50). Staining with H&amp;E revealed that 11/19 BM (57.9%) and 7/13 PT (53.8%) had apocrine differentiation. Analysis of OS showed no difference between patients with positive HFR (median OS 48 months) and negative HFR (median OS 69 months) (P=0.25). Similarly, there was no difference in OS between patients with apocrine differentiation (median OS 63 months) and those without apocrine differentiation (median OS 69 months) (P=0.49). Conclusions: To the best of our knowledge, this is the first analysis of HFR expression in BCBM. While previous studies associated the presence of HFR with worse prognosis; in this cohort of high-risk patients, HFR was positive in only 21.1% of BM with low levels of positivity. Around half of our patients had apocrine differentiation. Neither the status of HFR nor the presence of apocrine features had impact in OS in our cohort. Citation Format: Jose P Leone, Rohit Bhargava, Adrian Lee, Adam Brufsky. Expression of high affinity folate receptor in breast cancer brain metastasis [abstract]. In: Proceedings of the Thirty-Seventh Annual CTRC-AACR San Antonio Breast Cancer Symposium: 2014 Dec 9-13; San Antonio, TX. Philadelphia (PA): AACR; Cancer Res 2015;75(9 Suppl):Abstract nr P6-01-15.
Clinical breakpoint changes and their impact on surveillance of antimicrobial resistance in Escherichia coli causing bacteraemia
Authors: A.K. van der Bij, K. van Dijk, J. Muilwijk, S.F.T. Thijsen, D.W. Notermans, S. de Greeff, N. van de Sande-Bruinsma
Journal: Clinical Microbiology and Infection (2012)
A prescription for improvement? An observational study to identify how general practices vary in their growth in prescribing costs Commentary: Beware regression to the mean
Authors: A. J Avery
Journal: BMJ (2000)

<h3>Abstract</h3> <b>Objective:</b> To identify how some general practices have low growth in prescribing costs relative to other practices. <b>Design:</b> Observational study. <b>Setting:</b> Trent region of England. <b>Participants:</b> 162 general practices: 54 with low growth in prescribing costs, 54 with average increases in costs, and 54 with large increases in costs. <b>Main outcome measures:</b> Changes in prescribing costs in therapeutic categories in which it has been suggested that savings can be made. <b>Results:</b> There were significant differences between the three groups of practices in terms of their changes in prescribing costs for almost all the variables studied. For the group of practices with lowest growth in costs the most important factors were reducing numbers of prescription items and costs per item; relatively low growth in the costs of “new and expensive” drugs; increasing generic prescribing; and reducing costs for modified release products. This group of practices did not increase costs as much as the others for lipid lowering drugs (P=0.012) and hormone replacement therapy (P=0.007). The practices with the greatest increases in costs had particularly large increases for proton pump inhibitors, selective serotonin reuptake inhibitors, and modified release products. Compared with the other groups these practices had larger increases in costs for “expensive hospital initiated drugs” (P=0.009). <b>Conclusion:</b> General practices vary in their growth in prescribing costs in many ways, with growth in costs for “new and expensive” drugs being particularly important.
Cumulative Exposure to Ionizing Radiation From Diagnostic and Therapeutic Cardiac Imaging Procedures
Authors: Jersey Chen, Andrew J. Einstein, Reza Fazel, Harlan M. Krumholz, Yongfei Wang, Joseph S. Ross, Henry H. Ting, Nilay D. Shah, Khurram Nasir, Brahmajee K. Nallamothu
Journal: Journal of the American College of Cardiology (2010)
Flow cytometry as a tool for the study of cell kinetics in epidermis.
Authors: F. W. BAUER, N. H. C. M. N. CROMBAG, R. M. GROOD, G. J. JONGH
Journal: British Journal of Dermatology (1980)

Flow cytometric measurements of the DNA content were performed on a large number of skin biopsies by an automated technique. Expressed as a percentage of all viable cells in the epidermis, the figures for cells in S-phase averaged 1.8% and for G2M 0.9%. No significant differences due to sex were found. Concomitantly with age the ratio S/G2M (representing the duration of S to the duration of G2M) increased. Also seasonal effects were clear, showing higher values for S and G2M in June compared to November and December. Lastly we found small differences dependent on body-site, the ratio S/G2M being greater in legs than in arms. The present status is discussed together with future lines of development.
Abstract 15504: A New Coronary Anastomotic Connector in a Preclinical Safety Study
Authors: David Stecher, Gerard Pasterkamp, Marc P Buijsrogge
Journal: Circulation (2014)

Introduction: A facilitated construction of a distal coronary anastomosis is the key towards less invasive coronary bypass surgery, ideally in an endoscopic hybrid approach. This study evaluates a new laser-assisted, zero ischemia coronary anastomotic connector in comparison to the hand-sutured anastomotic technique, in a long-term follow-up porcine off-pump bypass model. The initial results of this preclinical comparative safety study are presented. Hypothesis: We assessed the hypothesis that the coronary connector is not inferior to the hand-sutured technique, in terms of patency, healing, and hemodynamic function. Methods: In 22 pigs (3 months follow-up, n=10; 6 months follow-up, n=12), the so-called Trinity Clip connector facilitated a LITA-to-LAD anastomosis, and in 14 pigs (3 months follow-up, n=6; 6 months follow-up, n=8) the anastomosis was hand-sutured. All anastomoses (n=36) were evaluated intraoperatively by means of graft flow measurements and at follow-up by angiography and histology. Results: After construction, complete hemostasis was obtained in 95% (21/22) of the connector facilitated anastomoses and in 86% (12/14) of the hand-sutured. Both groups had a mean coronary outer diameter of 1.8 ± 0.1 mm. The mean peak hyperemic flow response (peak [following 30-second graft occlusion]/base flow) was 4.1 ± 1.0 in the connector group versus 4.2 ± 1.1 in the hand-sutured group. The patency in both groups was 100% (connector group: at 6 months [n=3/3] and 3 months [n=5/5]; hand-sutured group: at 6 months [n=1/1] and 3 months [n=4/4]). Conclusions: The initial data of this preclinical study demonstrates similar anastomosis success rate in both groups. The connector is easy-to-use and seems to be safe and reliable in the long-term porcine off-pump bypass model. Complete data on the long-term will be expected soon and the resulting histological and angiographic data will further elucidate the future relevance of this new coronary anastomotic device. In conclusion, albeit the preliminary study status, the connector has potential to facilitate minimally invasive or endoscopic CABG.
Abstract 17: One Avocado Per Day Lowers Plasma Oxidized-LDL and Increases Plasma Antioxidants in Overweight and Obese Adults
Authors: Li Wang, Ling Tao, Todd H Stanley, Jennifer A Fleming, Joshua D Lambert, Penny M Kris-Etherton
Journal: Circulation (2015)

Background: Avocados are a nutrient dense source of monounsaturated fatty acids (MUFA) and also are high in antioxidants. A previous study has shown that avocados have additional LDL-C lowering effects beyond their MUFA content, especially on small, dense LDL particles, which are susceptible to oxidation in vivo. However, there is little information about the effects of avocados on oxidative stress. Methods and Result: A randomized, cross-over, controlled feeding trial was conducted with 45 healthy, but overweight or obese participants with a baseline LDL-C in the 25-90th percentile. Three cholesterol-lowering diets (6-7% SFA) were fed (for 5 weeks each): a lower-fat diet (LF: 24% fat); two moderate fat diets (34% fat) that provided similar foods and were matched for macronutrients and fatty acids: the avocado diet (AV) included one fresh Hass avocado (136 g) per day whereas the moderate fat diet (MF) used high oleic acid oils mainly to match the fatty acid content of one avocado. Compared to the baseline...
Protein kinase a-dependent pSer<sup>675</sup> -β-catenin, a novel signaling defect in a mouse model of congenital hepatic fibrosis
Authors: Carlo Spirli, Luigi Locatelli, Carola M. Morell, Romina Fiorotto, Stuart D. Morton, Massimiliano Cadamuro, Luca Fabris, Mario Strazzabosco
Journal: Hepatology (2013)

Genetically determined loss of fibrocystin function causes congenital hepatic fibrosis (CHF), Caroli disease (CD), and autosomal recessive polycystic kidney disease (ARPKD). Cystic dysplasia of the intrahepatic bile ducts and progressive portal fibrosis characterize liver pathology in CHF/CD. At a cellular level, several functional morphological and signaling changes have been reported including increased levels of 3'-5'-cyclic adenosine monophosphate (cAMP). In this study we addressed the relationships between increased cAMP and β-catenin. In cholangiocytes isolated and cultured from Pkhd1(del4/del4) mice, stimulation of cAMP/PKA signaling (forskolin 10 μM) stimulated Ser(675) -phosphorylation of β-catenin, its nuclear localization, and its transcriptional activity (western blot and TOP flash assay, respectively) along with a down-regulation of E-cadherin expression (immunocytochemistry and western blot); these changes were inhibited by the PKA blocker, PKI (1 μM). The Rho-GTPase, Rac-1, was also significantly activated by cAMP in Pkhd1(del4/del4) cholangiocytes. Rac-1 inhibition blocked cAMP-dependent nuclear translocation and transcriptional activity of pSer(675) -β-catenin. Cell migration (Boyden chambers) was significantly higher in cholangiocytes obtained from Pkhd1(del4/del4) and was inhibited by: (1) PKI, (2) silencing β-catenin (siRNA), and (3) the Rac-1 inhibitor NSC 23766.
The deoxyribonucleic acid (DNA) skin test in systemic lupus erythematosus.
Authors: E.A JOHANSSON, K-M. NIEMI, A. LASSUS
Journal: British Journal of Dermatology (1975)

SUMMARY A total of fifty-five biopsies from fifty-two intradermal DNA skin tests were studied. The biopsies were taken 6, 8–10,24 or 48 h after the injection of the DNA material. Necrosis of the vessel wall was taken to be the main characteristic of a specific reaction. In forty of the fifty-two tests the results of the histological evaluation closely matched the clinical results. In five of the fifteen cases with discrepancies, the histological evaluation ruled out clinically false positive test results. In three cases of SLE on corticosteroid treatment, the histological examination gave a positive result despite a clinically negative result. In seven of the fifteen cases the discrepancies occurred in borderline cases with reactions of 5 to 6 mm diameter. The amount of inflammatory cells in positive as well as in negative reactions was also recorded. The number of polymorphonuclear cells in positive reactions increased with the age of the reaction. The number of lymphocytes was not found to increase in the positive reactions, thus differing from the delayed hypersensitivity type of reactions. Rather, the reaction was characterized by an Arthus type of hypersensitivity. On the basis of the present study it may be concluded that clinically positive tests at 6 or 8 h may merely be expressions of nonspecific vascular alterations. On the other hand, in late reactions, even in patients on systemic treatment, histological examination revealed clinically negative results to be positive. By using the histological picture of hypersensitivity angiitis as the main diagnostic criterion the specificity of the clinical reactions may be established.
Therapy of Renal Diseases and Related Disorders
Authors: Wadi N. Suki, Shaul G. Massry
Journal: Annals of Internal Medicine (1991)

A handsome and rugged practical text and ready reference, revised and expanded with 13 new chapters, that blends theory and basic science with practical clinical applications for optimal therapeutic benefit. The 62 contributed chapters are logically organized into eight parts: disorders of fluid, el
Vaccination using class-I restricted epitope peptide derived from vascular endothelial growth factor receptor 2 induces specific cellular immune responses in patients with advanced cancer: a phase I study
Authors: Akira Kanamoto, Mari Sato, Masahisa Jinushi, Akihiko Ito, Hideaki Tahara
Journal: Clinical Cancer Research (2008)

AACR Centennial Conference: Translational Cancer Medicine-- July 20-23, 2008; Monterey, CA

B2 

Purpose: Angiogenesis has been shown to be a critical mechanism for tumor progression. Multiple studies have suggested that tumor growth can be suppressed if tumor angiogenesis can be inhibited using various types of anti-angiogenic agents. We have recently identified VEGFR2-derived epitope peptides restricted to HLA-A*0201 and A*2402 and shown they could be used in the clinical setting. A phase I study was conducted to investigate the safety and immunological response of the vaccination using VEGFR2 peptides.    Experimental Design: Patients with metastatic cancer received intradermal administrations of VEGFR2 peptide vaccine for four times with one week interval. All patients had advanced disease and received heavy chemotherapy prior to the entry. They have received HLA-A*2402-restricted or HLA-A*0201-restricetd peptide vaccine according to their HLA types. Clinical examination, radiological examination, and blood collection were performed regularly. Immune responses of the PBMC were measured with ELISPOT assay for IFN-γ response and MHC multimer assay for peptide-specific CD8+ T-cells.    Results: Nine patients have been enrolled in this study. In these patients, six patients have received HLA-A*2402-restricted peptide vaccine, and three patients have received HLA-A*0201-restricetd peptide vaccine. All the enrolled patients have completed the treatment, and five patients received additional doses as the treatment extension. Treatment was well tolerated with no serious adverse events related to the treatment. Significant immune responses were detected as early as 2 week after the 1st injection in some patients. Conclusion: These results suggest that VEGFR2-peptides can be safely administered. In some cases, the vaccination has induced specific immune responses even in the far advanced cancer patients. These results warrant further development of vaccination using VEGFR2 which appears to be an immunogenic antigen.
Health secretary admits that NHS rationing is government policy
Authors: Gavin Yamey
Journal: BMJ (1999)

Alan Milburn, England's health secretary, admitted this week that rationing is part of the government's modernisation agenda for the health service.

At a debate organised by the Institute for Public Policy Research in London Mr Milburn said: “The NHS—just like every other health system in the world, public or private—has never, or will never, provide all the care it might theoretically be possible to provide. That would probably be true even if the whole of the UK gross domestic product was …
Olanzapine vs Haloperidol for Treatment of Schizophrenia
Authors: William M Glazer
Journal: JAMA (2004)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Sustained survival of human hepatocytes in mice: A model for in vivo infection with human hepatitis B and hepatitis delta viruses
Authors: Kazuo Ohashi, Patricia L. Marion, Hiroyuki Nakai, Leonard Meuse, John M. Cullen, Bruno B. Bordier, Ralph Schwall, Harry B. Greenberg, Jeffrey S. Glenn, Mark A. Kay
Journal: Nature Medicine (2000)
Nipple-sparing mastectomy—is it worth the risk?
Authors: Jean-Yves Petit, Umberto Veronesi, Visnu Lohsiriwat, PierCarlo Rey, Giuseppe Curigliano, Stefano Martella, Cristina Garusi, Francesca De Lorenzi, Andrea Manconi, Edoardo Botteri, Florence Didier, Roberto Orecchia, Mario Rietjens
Journal: Nature Reviews Clinical Oncology (2011)
... and coeliac disease
Authors: C E Macdonald, R J Playford
Journal: BMJ (1996)

herbal medicines are in fact the effects of other herbal material used in error.This type of mistake is typified by the irritatingly common practice of naming vincristine and related anticancer compounds as Vinca alkaloids although they are derived from Catharanthus roseus.Unfortunately, classical taxonomists and phytoanalysts do not have the same glamour and potential to attract money as some other scientists and so are an endangered species.Their demise will result in mistakes more serious than the one in the editorial.
Simplified Test for Hematuria
Authors: T R ELDER, J L BARRY, P M FOLCIK, E M KNIGHTS
Journal: Annals of Internal Medicine (1962)

Brief Communication1 June 1962Simplified Test for HematuriaTHOMAS R. ELDER, M.B., CH.B., JACK L. BARRY, M.D., PAULINE M. FOLCIK, EDWIN M. KNIGHTS JR., M.D., F.A.C.P.THOMAS R. ELDER, M.B., CH.B.Search for more papers by this author, JACK L. BARRY, M.D.Search for more papers by this author, PAULINE M. FOLCIKSearch for more papers by this author, EDWIN M. KNIGHTS JR., M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-56-6-957 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptChemical tests for the detection of blood in the urine are based on the ability of hemoglobin to catalyze the oxidation of an indicator substance by hydrogen peroxide. In this investigation a new reagent stick test (Hemastix*) was evaluated. It consists of a stiff bibulous strip of cellulose in which the test end is impregnated with the reagents: o-tolidine as the indicator, cumene hydroperoxide in a stabilized form, and a citrate buffer to maintain the optimal pH. Hemoglobin catalyzes the oxidation of o-tolidine by cumene hydroperoxide to form a blue color. Also used in the investigation were commercially available tablets...Reference1. FREEFREEGIORANDO HMAHAS: Studies with a simple test for the detection of occult blood in urine. J. Urol. 75: 743, 1956. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Flint, MichiganFrom the Department of Pathology, Hurley Hospital, Flint 2, Michigan.Requests for reprints should be addressed to Edwin M. Knights, Jr., M.D., Department of Pathology, Hurley Hospital, Flint 2, Michigan.*Registered trademark of the Ames Company, Inc., Elkhart, Indiana. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byUrinalysisReview: Isolated Asymptomatic Hematuria in the AdultUromancy 1971: Tricks with SticksHematuria in children 1 June 1962Volume 56, Issue 6Page: 957-959KeywordsHematologic testsHemoglobinPatientsUrine ePublished: 1 December 2008 Issue Published: 1 June 1962 PDF downloadLoading ...
Abstract 11002: Anemia Plays a Role in Pre-Clinical Myocardial Damage and Cardiovascular Mortality in General Population
Authors: Yuki Honda, Tetsu Watanabe, Tetsuya Takahashi, Daisuke Kinoshita, Miyuki Yokoyama, Shinpei Kadowaki, Taro Narumi, Satoshi Nishiyama, Hiroki Takahashi, Takanori Arimoto, Tetsuro Shishido, Takuya Miyamoto, Isao Kubota
Journal: Circulation (2014)

Background: Anemia is an independent risk factor for morbidity and mortality in patients with cardiovascular disease. However, the impact of anemia on pre-clinical cardiac damage has not yet fully determined in apparently healthy subjects. The aim of the present study was to investigate whether anemia is associated with pre-clinical cardiac damage and cardiovascular mortality in general population. Methods and Results: A cohort study was conducted with subjects who participated in a community-based annual health check in Takahata, Japan, from 2004 through 2006. We examined blood count, serum levels of brain-type natriuretic peptide (BNP) and heart-type fatty acid binding protein (H-FABP) in participants and prospectively followed them (n = 3,509). Anemia was defined as hemoglobin &lt; 13 g/dl for men; &lt; 12 g/dl for women. Four hundred subjects (11.4%) had anemia. In both gender, BNP levels were higher in subjects with anemia than in those without. H-FABP levels were also higher in male subjects with anemia than in those without, while anemia was not associated with H-FABP levels in female subjects. During follow-up period of 7 years, 40 subjects died of cardiovascular diseases. Kaplan-Meier analysis demonstrated that subjects with anemia had higher cardiovascular mortality than those without. Further, subjects those with macrocytic anemia, defined as anemia with mean corpuscular volume (MCV) ≥ 100 fl, had the highest levels of BNP and H-FABP and the highest event rate among subjects with anemia. Multivariate Cox proportional hazard analysis revealed that anemia was an independent predictor of cardiovascular diseases after adjusting age, gender, smoking index, estimated glomerular filtration rate, and BNP (HR: 2.307; 95% CI, 1.032 - 4.808). Conclusions: Anemia, especially macrocytic anemia, was associated with pre-clinical myocardial damage and cardiovascular mortality in general population.