tbuckley/cabot-search huggingface dataset:
The National Committee for Quality Assurance
Authors: John K. Iglehart
Journal: New England Journal of Medicine (1996)

The quality of medical care provided by managed-care plans is an increasingly complicated and controversial topic.17 Traditionally, the quality of care has been measured by professional judgment, often rendered subjectively in individual cases.8 Now, as health care delivery and financing are being reordered by the rapid growth of managed care, physicians and the health plans with which they contract are being called to greater account for the quality of the services they provide. The scrutiny is coming largely from corporations and governments, which are concerned that as health plans compete, they may stint on services to reduce prices.9 In . . .
A piece of my mind. The hymn
Authors: D. N. Little
Journal: JAMA (1993)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Compound Protects Against Ionizing Radiation by Unique Mechanism
Authors: Tracy Hampton
Journal: JAMA (2013)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Diagnosis of systemic lupus erythematosus from a bone marrow aspirate
Authors: Abbas Hashim Abdulsalam, Nafila Sabeeh, Abdulsalam Hatim, Barbara J. Bain
Journal: American Journal of Hematology (2011)

An 18-year-old Iraqi girl presented with fever and a generalized rash. The spleen was palpable four cm below the left costal margin. A full blood count showed: white cell count 3 × 109/l, hemoglobin concentration 97 g/l, platelet count 63 × 109/l, neutrophil count 2.2 × 109/l and lymphocyte count 0.6 × 109/l. A bone marrow aspirate performed to investigate the thrombocytopenia showed a normocellular marrow with normal numbers of megakaryocytes. In addition numerous LE cells were detected (left image). The LE cells were detected in bone marrow films spread immediately without any anticoagulation, incubation or other manipulation. The diagnosis of systemic lupus erythematosus (SLE) was confirmed by the demonstration of antinuclear antibody and anti-double stranded DNA antibody. An LE cell is a neutrophil that has ingested denatured nuclear material of another cell as the result of antinuclear activity in the plasma. This phenomenon was first described in the bone marrow in 1948 with a Feulgen stain being used to demonstrate that the ingested material was DNA [1]. In the subsequent year an in vitro test was reported using either buffy coat cells or normal bone marrow components plus the patient's plasma [2]. Hargraves and colleagues [1] also described the phenomenon shown in the right image – “numerous mature polymorphonuclear leukocytes attempting to pick up the same mass of material”. With the availability of serological tests an LE cell preparation is now rarely used for the diagnosis of SLE. However the observation of LE cells in a bone marrow aspirate can still provide confirmation of this diagnosis.
New, but Not Improved? Incorporating Comparative-Effectiveness Information into FDA Labeling
Authors: Randall S. Stafford, Todd H. Wagner, Philip W. Lavori
Journal: New England Journal of Medicine (2009)

The FDA does not currently require label statements regarding a product's comparative effectiveness. Dr. Randall Stafford, Todd Wagner, and Philip Lavori propose an expanded labeling requirement that would provide explicit information about proven comparative benefits or lack thereof.
Abstract 170: Thymoquinone-mediated suppression of NF- αB activity causes inhibition of cell viability and induces apoptosis in activated B-cell sub-type of diffuse large B-cell lymphoma
Authors: Azhar R. Hussain, Saeeda O. Ahmed, Maqbool Ahmed, Omar S. Khan, Shahab Uddin, Khawla S. Al-Kuraya
Journal: Cancer Research (2012)

Abstract Diffuse Large B-cell Lymphoma (DLBCL) is the most common lymphoid malignancy and constitutes approximately 40% of all cases of non-Hodgkin's lymphoma (NHL). Despite improvement in treatment protocols, a large number of DLBCL cases remain refractory to treatment. DLBCL can be further classified as three distinct subtypes: germinal center B cell-like (GCB)-, activated B cell-like (ABC)-, and primary mediastinal B-cell lymphoma (PMBL). ABC DLBCL has a worse survival after upfront chemotherapy and is characterized by constitutive activation of the anti-apoptotic nuclear factor-kappa B (NF-κB) pathway. Yet the implication of NF-κB inhibition in ABC DLBCL need to be further elucidated. We have previously shown that Thymoquinone (TQ), a natural compound isolated from Nigella sativa, induces growth inhibition and induces apoptosis in several NHL cell lines. However its role in inhibition of growth and apoptosis has not been fully elucidated in ABC sub-type of DLBCL cell lines. We found that TQ treatment inhibits cell viability and induces apoptosis in a dose dependent manner in various ABC cell lines. Further more, we found that TQ treatment causes inactivation of IκBα and consequently inhibits NF-κB activity by decreasing the expression of p65 subunit of NF-κB in the nuclear compartment of ABC cell lines. In-activation of NF-κB survival pathway leads to induction of apoptosis via the mitochondrial apoptotic pathway initiated by conformational changes in the Bax protein leading to changes in the mitochondrial membrane potential and release of cytochrome c in the cytosole. Once cytochrome c is released, it leads to activation and cleavage of caspases-9 and -3 and cleavage of PARP. This leads to caspase dependent apoptosis in ABC cell lines. In addition, we also found that TQ treatment causes up-regulation of death receptor 5 (DR5), an important and essential receptor for tumor necrosis factor related apoptosis inducing ligand (TRAIL). However, up-regulation of DR5 does not play a role in TQ-induced apoptosis in ABC cell lines. Interestingly, combination of sub-toxic doses of TQ and TRAIL induces efficient significant apoptosis in ABC cell lines. These data show that TQ can be used alone or in combination with TRAIL to induce apoptosis in these aggressive sub-types of DLBCL and may play an important role in the management of DLBCL in the future. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 103rd Annual Meeting of the American Association for Cancer Research; 2012 Mar 31-Apr 4; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2012;72(8 Suppl):Abstract nr 170. doi:1538-7445.AM2012-170
Adenosine: a sensitive marker of myocardial ischaemia in man
Authors: H. J Bardenheuer, A. Fabry, B. Hofling, K. Peter
Journal: Cardiovascular Research (1994)

Journal Article Adenosine: a sensitive marker of myocardial ischaemia in man Get access Hubert J Bardenheuer, Hubert J Bardenheuer University of Munich, Munich, Germany—Department of Anaesthesiology: H J Bardenheuer, A Fabry, K Peter; Department of Medicine: B Höfling. Correspondence to Professor Bardenheuer, at Department of Anaesthesiology, University of Heidelberg, Im Neuenheimer Feld 110, D-69120 Heidelberg, Germany. Search for other works by this author on: Oxford Academic PubMed Google Scholar Andrea Fabry, Andrea Fabry University of Munich, Munich, Germany—Department of Anaesthesiology: H J Bardenheuer, A Fabry, K Peter; Department of Medicine: B Höfling. Search for other works by this author on: Oxford Academic PubMed Google Scholar Berthold Höfling, Berthold Höfling University of Munich, Munich, Germany—Department of Anaesthesiology: H J Bardenheuer, A Fabry, K Peter; Department of Medicine: B Höfling. Search for other works by this author on: Oxford Academic PubMed Google Scholar Klaus Peter Klaus Peter University of Munich, Munich, Germany—Department of Anaesthesiology: H J Bardenheuer, A Fabry, K Peter; Department of Medicine: B Höfling. Search for other works by this author on: Oxford Academic PubMed Google Scholar Cardiovascular Research, Volume 28, Issue 5, May 1994, Pages 656–662, https://doi.org/10.1093/cvr/28.5.656 Published: 01 May 1994 Article history Received: 18 August 1993 Accepted: 23 December 1993 Published: 01 May 1994
Binding of the chemokine SLC/CCL21 to its receptor CCR7 increases adhesive properties of human mesangial cells
Authors: Bernhard Banas, Markus Wörnle, Monika Merkle, Mercedes Gonzalez-Rubio, Holger Schmid, Matthias Kretzler, Miriam C. Pietrzyk, Monika Fink, Guillermo Perez De Lema, Detlef Schlöndorff
Journal: Kidney International (2004)
Mechanisms of neutrophil accumulation in the lungs of patients with idiopathic pulmonary fibrosis.
Authors: G W Hunninghake, J E Gadek, T J Lawley, R G Crystal
Journal: Journal of Clinical Investigation (1981)

Neutrophils are a characteristic feature of the alveolitis of idiopathic pulmonary fibrosis (IPF). a chronic disorder limited to lung. One mechanism by which neutrophils may be selectively attracted to lung and not other tissues is via the secretion of the neutrophil-specific chemotactic factor by alveolar macrophages. To evaluate the role of alveolar macrophages in modulating the migration of neutrophils to he lung in IPF, alveolar macrophages, obtained by bronchoalveolar lavage of patients with IPF, were evaluated for their ability to release a chemotactic factor for neutrophils. Unstimulated alveolar macrophages from normal individuals did not release the factor. In patients with IPF, there was a significant correlation between the proportions of neutrophils in lavage fluid and the release of a chemotactic factor for neutrophils by alveolar macrophages (p less than 0.001). The chemotactic factor released by IPF alveolar macrophages was of low molecular weight (400-600), at least partially lipid in nature, and preferentially attracted neutrophils compared with monocytes. Several lines of evidence suggested that immune complexes in the lung stimulated alveolar macrophages of patients with IPF to release the chemotactic factor. First, immune complexes stimulated normal macrophages to release the factor.Second, there was a significant correlation between the release of the chemotactic factor by IPF alveolar macrophages and the levels of immune complexes in bronchoalveolar lavage fluid. Third, bronchoalveolar lavage fluid containing immune complexes stimulated normal macrophages to release the factor. Fourth, IPF alveolar macrophages that released large amounts of the chemotactic factor had an apparent suppression of their immunoglobulin (Ig)G Fc receptor function, suggesting that immune complexes were bound to their surface. In contrast, the IgG Fc receptor function of IPF alveolar macrophages that released only small amounts of the factor was similar to that of normal macrophages. These studies suggest that neutrophils are attracted to the lung in patients with IPF by a potent chemotactic factor released by alveolar macrophages that have been stimulated, in vivo, via their IgG Fc receptor by immune complexes.
An obligate role for T-cell receptor αβ+ T cells but not T-cell receptor γδ+ T cells, B cells, or CD40/CD40L interactions in a mouse model of atopic dermatitis
Authors: Amy L. Woodward, Jonathan M. Spergel, Harri Alenius, Emiko Mizoguchi, Atul K. Bhan, Emanuela Castigli, Scott R. Brodeur, Hans C. Oettgen, Raif S. Geha
Journal: Journal of Allergy and Clinical Immunology (2001)
Occupational allergy caused by spathe flower (<i>Spathiphyllum wallisii</i>)
Authors: L. Kanerva, S. Mäkinen‐Kiljunen, R. Kiistala, H. Granlund
Journal: Allergy (1995)

Occupational allergy caused by plants is seldom reported although it is probably relatively common. We report on a 22‐year‐old male atopic caretaker of plants who developed IgE‐mediated allergic rhinitis, laryngitis, pharyngitis, and contact and generalized urticaria caused by exposure to spathe flower ( Spathiphyllum wallisii ) while he was working for a firm that supplied plants to offices. He also had an asthmatic attack at work, but in bronchial provocation tests conducted 8 months after he had stopped doing the work in question, he developed rhinoconjunctivitis, pharyngitis, and laryngitis, but exhibited neither bronchial reaction nor fall in PEF values. Prick tests with spathe flower gave 3 + reactions for exudates from the flower, pollen, stem, and leaves. He also had several positive reactions to fruits, vegetables, and spices, but not to natural rubber latex. The radioallergosorbent test with spathe flower was positive (3.4 PRU/ml, close to class 3). In protein staining with SDS—PAGE, one heavy band was detected at about 14 kDa, and other faint bands were visible on both sides. Six faint bands were detected at the mol. mass range of 30–67 kDa. In IgE immunoblotting, one heavy band was detected at about 14 kDa. The patient became symptomless after he had ceased working with plants.
Peptidase activities of the multicatalytic protease in rat liver after voluntary and intragastric ethanol administration
Authors: Terrence M. Donohue, Rowen K. Zetterman, Zhi-Qi Zhang-Gouillon, Samuel W. French
Journal: Hepatology (1998)

Ethanol consumption slows down the rate of hepatic protein catabolism. The present study was conducted to determine whether ethanol consumption, given by voluntary (pair) feeding or by intragastric administration, affected the peptidase activities of the proteasome in rat liver. Rats were pair-fed liquid diets containing either ethanol or isocaloric maltose-dextrin. A separate group of animals was intragastrically infused continuously with similar liquid diets containing either ethanol or isocaloric dextrose. Crude liver homogenates and their cytosolic fractions were assayed for their chymotrypsin-like (Cht-L), trypsin-like (T-L), and peptidyl-glutamyl-peptide hydrolase (PGPH) activities, using specific fluorogenic peptides as substrates. Voluntary ethanol feeding did not affect the three peptidase activities of the proteasome. However, intragastric ethanol administration caused a 35% to 40% decline in the Cht-L and the T-L activities, but did not significantly change the PGPH activity. The lower peptidase activities in cytosol samples from intragastrically ethanol-fed rats were not restored to control levels by overnight dialysis, nor by the inclusion of low levels of sodium dodecyl sulfate (SDS) or of 0.5 mmol/L adenosine triphosphate (ATP) in the proteasome assay mixture. Immunoblot analyses using anti-rat liver proteaseome exhibited equal levels of immunoreactive proteasome subunits in livers of control and ethanol-fed rats. Similar results were obtained when blots were probed with antibody made specifically against the proteasome subunit, LMP-7. The results indicate that intragastric, but not voluntary, ethanol consumption differentially affects the separate catalytic activities of the proteasome without affecting its steady-state levels. Such changes may be related to the degree of ethanol-induced oxidative stress.
Epidemiology and clinical significance of cervical erosion in women attending a family planning clinic.
Authors: M J Goldacre, N Loudon, B Watt, G Grant, J D Loudon, K McPherson, M P Vessey
Journal: BMJ (1978)

Women attending a family planning clinic were studied to determine the relation between cervical erosion and clinical and social characteristics. The appearance of the cervix was recorded without knowledge of the women's symptoms. The prevalence of erosion increased with parity but, when the effects of other factors were controlled, decreased in women aged 35 and over. Erosion was significantly more common in women taking the "pill" and less common in women using barrier methods of contraception than in others. There was considerable variation between doctors in the reporting of erosion. No association was found between erosion and postcoital bleeding, dyspareunia, backache, or dysuria. There was a significant but modest association between erosion and vaginal discharge and a suggestion that erosion may sometimes be associated with nocturia and frequency of micturition. Vaginal flora was similar in women with and without erosion. Cervical erosion should not be regarded as pathological in asymptomatic women, nor should it be assumed necessarily to be the cause of symptoms in women with genitourinary complaints.
Effect of H+ ion activity and Ca2+ on the toxicity of metals in the environment.
Authors: T C Hutchinson, F W Collins
Journal: Environmental Health Perspectives (1978)

The role of acidity in determining and restricting plant distribution and performance is discussed. In soils especially, a key effect of H+ ion concentration is on the solubility of potentially toxic heavy metals such as aluminum, managenese, zinc, iron, copper, and nickel. Al has been reported from many studies since the 1920's as the key determining toxic factor in acid soils. Some acid-tolerant species have been shown to be especially tolerant of Al, and mechanisms of tolerance have been suggested. Mn is also a commonly toxic factor at soil pH less than 5.0. Calcium has been shown to alleviate Mn toxicity. Low pH soils are also generally low in Ca, K, Na, and P; all essential major elements for plant growth. In lakes and marine situations acidic waters are uncommon as the waters are buffered. Calcium is again ameliorative of metal toxicities. The pH, redox, and valency state are critical in determining nutrient availability and metal speciation. Recent increases in the H+ ion content of precipitation have caused increased acidities of freshwater lakes in Scandinavia and eastern North America, which have depleted biota, including fish populations.
THE PERMEABILITY OF HUMAN SWEAT GLANDS TO A SERIES OF SULFONAMIDE COMPOUNDS
Authors: Jørn Hess Thaysen, Irving L. Schwartz
Journal: The Journal of Experimental Medicine (1953)

A series of sulfonamide compounds, para-aminohippurate, and inulin were used to study the permeability of the epithelium of human sweat glands. Inulin was not excreted in the sweat. The ratios of the concentrations in sweat to the concentrations in plasma, S/P, of sulfanilamide, sulfapyridine, sulfathiazole, sulfadiazine, and para-aminohippurate were found to be 0.69, 0.58, 0.13, 0.11, and 0.02 respectively, independent of the plasma concentrations and the sweating rates. The fact that the S/P ratios are thus unaffected by the absolute number of molecules transported suggests that these compounds enter into the sweat by simple diffusion and not via a specific secretory mechanism which could become saturated by increasing load. If this is so, the difference in the S/P ratios must be explained by an unequal permeability of the epithelium of the sweat gland to the various compounds and some explanation for these differences in the rate of excretion must exist in terms of physicochemical properties of the compounds. A comparison between the S/P ratios and the pK values of the various sulfonamides indicates that the differences in their rates of excretion in the sweat depend upon the degree of ionization of the various compounds at the physiological pH. Compounds which are mainly non-ionized are excreted with high S/P ratios, whereas ionized compounds appear with low ratios. A quantitative relationship was shown to exist between the S/P ratio for each compound and the percentage of the compound which is non-ionized at pH 7.4.
Prevalence and Risk Factors for Urinary Incontinence in Italy
Authors: A. Bortolotti, B. Bernardini, E. Colli, P. Di Benedetto, G. Giocoli Nacci, M. Landoni, M. Lavezzari, A. Pagliarulo, S. Salvatore, M. von Heland, F. Parazzini, W. Artibani
Journal: European Urology (2000)
Metabolic effects of nigrostriatal denervation in basal ganglia
Authors: Etienne C. Hirsch, Céline Périer, Gaël Orieux, Chantal François, Jean Féger, Jér⩽ ome Yelnik, Miquel Vila, Richard Levy, Eduardo S. Tolosa, Concepcio Marin, M. Trinidad Herrero, José A. Obeso, Yves Agid
Journal: Trends in Neurosciences (2000)
GOLGA2/GM130, cis-Golgi Matrix Protein, is a Novel Target of Anticancer Gene Therapy
Authors: Seung-Hee Chang, Seong-Ho Hong, Hu-Lin Jiang, Arash Minai-Tehrani, Kyeong-Nam Yu, Jae-Ho Lee, Ji-Eun Kim, Ji-Young Shin, Bitna Kang, Sungjin Park, Kiwon Han, Chanhee Chae, Myung-Haing Cho
Journal: Molecular Therapy (2012)

Achievement of long-term survival of patients with lung cancer treated with conventional chemotherapy is still difficult for treatment of metastatic and advanced tumors. Despite recent progress in investigational therapies, survival rates are still disappointingly low and novel adjuvant and systemic therapies are urgently needed. A recently elucidated secretory pathway is attracting considerable interest as a promising anticancer target. The cis-Golgi matrix protein, GOLGA2/GM130, plays an important role in glycosylation and transport of protein in the secretory pathway. In this study, the effects of short hairpin RNA (shRNA) constructs targeting GOLGA2/GM130 (shGOLGA2) on autophagy and lung cancer growth were evaluated in vitro and in vivo. Downregulation of GOLGA2/GM130 led to induction of autophagy and inhibition of glycosylation in A549 cells and in the lungs of K-ras(LA1) mice. Furthermore, downregulation of GOLGA2/GM130 decreased angiogenesis and cancer cell invasion in vitro and suppressed tumorigenesis in lung cancer mice model. The tumor specificity of sequence targeting GOLGA2/GM130 was also demonstrated. Taken together, these results suggest that induction of autophagy by shGOLGA2 may induce cell death rather than cell survival. Therefore, downregulation of GOLGA2/GM130 may be a potential therapeutic option for lung cancer.
IMPACT OF MYOCARDIAL MID WALL FIBROSIS AND CHAMBER REMODELING ON LEFT VENTRICULAR WALL STRESS AS QUANTIFIED BY CARDIAC MAGNETIC RESONANCE (CMR) IMAGING
Authors: Jiwon Kim, Jonathan Kochav, Sergey Gurevich, Anika Afroz, Maya Petashnick, Samuel Volo, Belen Diaz, Peter Okin, Evelyn Horn, Richard Devereux, Jonathan Weinsaft
Journal: Journal of the American College of Cardiology (2014)