tbuckley/cabot-search huggingface dataset:
TRANSIENT "0" DIASTOLIC BLOOD PRESSURE (INDIRECT) IN THE UPPER EXTREMITIES
Authors: I STEIN
Journal: Annals of Internal Medicine (1949)

Article1 March 1949TRANSIENT "0" DIASTOLIC BLOOD PRESSURE (INDIRECT) IN THE UPPER EXTREMITIESISIDORE STEIN, M.D.ISIDORE STEIN, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-30-3-615 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptRecently Wilburne1described a benign cardiovascular syndrome, the most prominent features of which were transient "0" brachial diastolic pressure, normal or elevated popliteal pressure, tachycardia and nervous tension occurring usually in young adults. He felt that the syndrome was psychosomatic in nature and that although the true brachial diastolic pressure probably was not "0", in all likelihood it was subnormal. The reduced diastolic pressure in the brachial arteries appeared to be due to peripheral vascular dilatation. The presence in the lower extremities of normal or increased pressure was considered to represent a compensatory phenomenon directed towards the maintenance of cerebral...Bibliography1. WILBURNE M: Transient "0" diastolic brachial pressure (indirect), associated with normal or elevated popliteal pressure, tachycardia and nervous tension, Am. Heart Jr., 1945, xxx, 381. CrossrefGoogle Scholar2. MAIZNERKRAUSE FM: The influence of fear on the electrocardiogram, British Heart Jr., 1940, ii, 221. Google Scholar3. WENDKOS MH: The influence of autonomic imbalance on the human electrocardiogram. I. Unstable T waves in the precordial leads from emotionally unstable persons without organic heart disease, Am. Heart Jr., 1944, xxviii, 549. CrossrefGoogle Scholar4. STEIN I: A study of abnormal T waves in patients presenting no evidence of organic heart disease, Jr. Lab. and Clin. Med., 1946, xxxi, 837. Google Scholar5. EVANSSTEWART WFHJ: The effect of smoking cigarettes on the peripheral blood flow, Am. Heart Jr., 1943, xxvi, 78. CrossrefGoogle Scholar6. DOWNMANGOGGIOMCSWINEYYOUNG CBAFBAMH: Reflex vasomotor responses of the paw of the cat, Jr. Physiol., 1943, cii, 216. CrossrefGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Brooklyn, New York*Received for publication November 25, 1947. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byHypertonie 1 March 1949Volume 30, Issue 3Page: 615-618KeywordsArteriesBlood pressureTachycardiaYoung adults ePublished: 1 December 2008 Issue Published: 1 March 1949 PDF downloadLoading ...
5-Fluorouracil Filtering Surgery and Neovascular Glaucoma
Authors: James C. Tsai, William J. Feuer, Richard K. Parrish, Alana L. Grajewski
Journal: Ophthalmology (1995)

Background: The long-term efficacy and safety of filtering surgery with 5-fluorouracil (5-FU) in eyes with neovascular glaucoma are unknown. Methods: Kaplan-Meier survival curve analysis of surgical outcome was performed on all 34 patients (34 eyes) enrolled from May 1982 through April 1986 in the original pilot study of filtering surgery with 5-FU. Results: Success rates at the 1-, 2-, 3-, 4-, and 5-year intervals were 71 %, 67%, 61 %, 41 %, and 28%, respectively. The median filter survival time was 38.7 months (95% confidence interval: 32–45 months). Twelve (35%) of 34 patients lost light perception vision, and phthisis bulbi developed in 8 (24%) of 34 patients. Age of 50 years or younger (P < 0.0001) and type 1 diabetes (P = 0.0004) were significant risk factors for surgical failure. The 1-year success rate for patients no older than 50 years of age was 23% compared with a 95% success rate in patients older than 50 years of age. After adjustment for age, type 1 diabetes was a borderline risk factor (P = 0.06). Conclusion: There is a high risk of long-term failure of filtering surgery with 5-FU in neovascular glaucoma. Patients 50 years of age or younger have an extremely poor prognosis. Patients older than 50 years of age have initial short-term success with an accelerated failure rate after 3 years. Background: The long-term efficacy and safety of filtering surgery with 5-fluorouracil (5-FU) in eyes with neovascular glaucoma are unknown. Methods: Kaplan-Meier survival curve analysis of surgical outcome was performed on all 34 patients (34 eyes) enrolled from May 1982 through April 1986 in the original pilot study of filtering surgery with 5-FU. Results: Success rates at the 1-, 2-, 3-, 4-, and 5-year intervals were 71 %, 67%, 61 %, 41 %, and 28%, respectively. The median filter survival time was 38.7 months (95% confidence interval: 32–45 months). Twelve (35%) of 34 patients lost light perception vision, and phthisis bulbi developed in 8 (24%) of 34 patients. Age of 50 years or younger (P < 0.0001) and type 1 diabetes (P = 0.0004) were significant risk factors for surgical failure. The 1-year success rate for patients no older than 50 years of age was 23% compared with a 95% success rate in patients older than 50 years of age. After adjustment for age, type 1 diabetes was a borderline risk factor (P = 0.06). Conclusion: There is a high risk of long-term failure of filtering surgery with 5-FU in neovascular glaucoma. Patients 50 years of age or younger have an extremely poor prognosis. Patients older than 50 years of age have initial short-term success with an accelerated failure rate after 3 years.
ANOTHER CASE OF INTESTINAL MYIASIS
Authors: Marcus W. Lyon, John D. Mizelle
Journal: Annals of Internal Medicine (1945)

Case Reports1 January 1945ANOTHER CASE OF INTESTINAL MYIASISMARCUS W. LYON JR., M.D., JOHN D. MIZELLE, PH.D.MARCUS W. LYON JR., M.D.Search for more papers by this author, JOHN D. MIZELLE, PH.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-22-1-128 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptWhereas larvae of Gastrophilus species which produce horse bots are true intestinal parasites, larvae of other genera (Lucilia, Calliphora, Piophila, Fannia, Phormia, Musca, etc.) are apparently plastic enough in their habits to live for different periods of time in the digestive tract of mammals.The older opinion regarding the prevalence of intestinal myiasis is well expressed by Walsh who says, "Taking everything into consideration, we doubt whether, out of ten thousand cases, where the larvae of two-winged flies have existed in considerable numbers in the human intestines, more than one single case has been reported in print by competent entomological...Bibliography BANKS N: The structure of certain dipterous larvae, U. S. Bur. Ent. Tech. Bull., 22, 1912. Google Scholar CHANDLER AC: Introduction to parasitology, 1940, John Wiley & Sons, New York. Google Scholar CHANDLER AC: A case of urinary myiasis, Jr. Parasitol., 1941, xxvii, 465. CrossrefGoogle Scholar HERMSGILBERT WBQO: An obstinate case of intestinal myiasis, Ann. Int. Med., 1933, vi, 941-945. LinkGoogle Scholar NEVEU-LEMAIRE M: Parasitologie des animaux domestiques, 1912, J. Lamarre et Cie, Paris. Google Scholar PARKER GH: Possible paedogenesis in the blow-fly, Calliphora erythrocephala , Meigen. Psyche, 1922, xxxix, 127-131. CrossrefGoogle Scholar RILEYJOHANNSEN WAOA: Medical entomology, 1938, Hill Book Co., New York. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: *Received for publication March 30, 1943.†Dr. Marcus W. Lyon, Jr., formerly of the South Bend Clinic, South Bend, Indiana died May 18, 1942. The junior author is a member of the Department of Biology, University of Notre Dame, Notre Dame, Indiana. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byGastrointestinal Myiasis 1 January 1945Volume 22, Issue 1Page: 128-130KeywordsGastroenterology and hepatologyGastrointestinal tractHabits ePublished: 1 December 2008 Issue Published: 1 January 1945 PDF downloadLoading ...
Abstract MP03: Associations Of 24-hour Blood Pressure Patterns With Cognitive Function In Healthy Older Adults
Authors: Kyle Conway, Nketi Forbang, Tomasz Beben, Michael Criqui, Joachim Ix, Dena Rifkin
Journal: Circulation (2014)

Background: Abnormal 24-hour ambulatory blood pressure monitoring (ABPM) patterns have been associated with diminished cognitive function in hypertensive and very elderly populations. The relationship between ABPM patterns in community-living older adults is unknown. Methods: We conducted a cross-sectional study in which ABPM, in-clinic blood pressure, and cognitive function measures were obtained in 354 community living older adults. We used multiple linear regression to examine the associations of in-clinic and ABPM with the Montreal Cognitive Assessment (MoCA [range 0-30 with lower levels indicating worse cognition]), adjusting for age, sex, race/ethnicity, education, and comorbid medical conditions. Results: The mean age was 72 years, 68% were female, and 13% were African American; 45% had a diagnosis of hypertension. In-clinic blood pressure measurements were not significantly associated with cognitive function after adjustment. In contrast, less nighttime systolic dipping percentage (Figure) and lower 24-hour average diastolic blood pressure obtained from the ABPM were both significantly associated with worse cognitive function. In the final model, each 1% less night-time dipping was associated with 0.25 points (0.1-0.9) lower MoCA score, whereas each 10 mmHg lower diastolic blood pressure was associated with 0.59 (0.14-1.05) points lower MoCA score. Conclusions: In community-living older persons, less nighttime systolic dipping and lower 24-hour diastolic blood pressure obtained by ABPM were associated with worse cognitive function whereas clinic based blood pressure measurements were not. Future studies should examine whether 24-hour diastolic blood pressure and nighttime systolic dipping may predict future risk for cognitive impairment. (Legend: Dipping quartiles: Q1 -17.8% to 6.0%; Q2 6.1% to 11.0%; Q3 11.1% to 16.3%; Q4 16.4% to 34.2%)
Abstract # 11025: Vasoreactivity to Inhaled Nitric Oxide Predicts Long-term Survival in Pulmonary Arterial Hypertension
Authors: Rajeev Malhotra, Dean Hess, Gregory D. Lewis, Kenneth D. Bloch, Aaron B. Waxman, Marc J. Semigran
Journal: Circulation (2010)

Introduction: Pulmonary vasodilator testing is currently used to guide the use of calcium channel antagonists (CCA) in patients with pulmonary arterial hypertension (PAH). However, the utility of t...
MLH1 promoter methylation in suspected Estonian Lynch syndrome families
Authors: Egle Rebane, Martin Kask, Olga Kostina, Wally Anderson
Journal: Clinical Cancer Research (2010)

Abstract Background: Microsatellite instability (MSI) occurs in 10-20% of colorectal cancer (CRC), and has been attributed to both MLH1 promoter hypermethylation and germline mutation in the mismatch repair (MMR) genes. Inactivation of MLH1 due to promoter hypermethylation strongly suggests a sporadic origin, providing exclusion criteria for Lynch syndrome. The aim of the study is to show the need to perform MLH1 methylation analysis in all MSI-H tumors before sequencing of MLH1 gene in Estonian clinical practice. Methods: The study group included 50 tumors DNA from colorectal cancer patients who fulfill the Amsterdam criteria or met at least one of the revised Bethesda criteria. MSI and activating mutations of BRAF and KRAS were identified in all tumor samples. Methylation of the 5’ regulatory MLH1 region C at −197 to −295 bp (from the transcriptional start site) was analyzed by high-resolution melting (HRM) and also was performed methylation specific-MLPA (MS-MLPA) in all MSI-H cases. Results: The average age of colorectal patients was 46 (29 to 79) years. MSI-H, BRAF and KRAS mutations were observed in 16, 1 and 14 out of all cases, respectively. Tumor localization was right-side in 9 of the MSI-H cases. Hypermethylation of the MLH1 promoter was found in 2 MSI-H tumors with KRAS mutation and right-side tumor localization. Conclusion: The patients selection for the study is ongoing. Methylation analysis of MLH1 can give better performance characteristics in the selection of patients for sequencing of MLH1.
The Medical Care of the Cancer Patient.
Authors: Susan N. Rosenthal, Joanne R. Carignan, Brian D. Smith
Journal: Annals of Internal Medicine (1931)

Interns and residents do not seem to have the same enthusiasm for building a professional library they had in years past. Perhaps this is because modern textbooks are too big, too expensive, and too quickly obsolete to be an attractive investment. Ready access to on-line databases may be another factor. The sight of a house officer searching the medical literature via computer before or during rounds is becoming commonplace. What if, however, there were a reasonably comprehensive, very current textbook of medical oncology in a format
Critical Role of Histone Turnover in Neuronal Transcription and Plasticity
Authors: Ian Maze, Wendy Wenderski, Kyung-Min Noh, Rosemary C. Bagot, Nikos Tzavaras, Immanuel Purushothaman, Simon J. Elsässer, Yin Guo, Carolina Ionete, Yasmin L. Hurd, Carol A. Tamminga, Tobias Halene, Lorna Farrelly, Alexey A. Soshnev, Duancheng Wen, Shahin Rafii, Marc R. Birtwistle, Schahram Akbarian, Bruce A. Buchholz, Robert D. Blitzer, Eric J. Nestler, Zuo-Fei Yuan, Benjamin A. Garcia, Li Shen, Henrik Molina, C. David Allis
Journal: Neuron (2015)
Allogeneic marrow transplantation in patients with acute myeloid leukemia in first remission: a randomized trial of two irradiation regimens [see comments]
Authors: RA Clift, CD Buckner, FR Appelbaum, SI Bearman, FB Petersen, LD Fisher, C Anasetti, P Beatty, WI Bensinger, K Doney
Journal: Blood (1990)
THE PRESIDENT'S REPORT
Authors: Leroy H. Sloan
Journal: Annals of Internal Medicine (1954)

Article1 August 1954THE PRESIDENT'S REPORTLEROY H. SLOAN, F.A.C.P.LEROY H. SLOAN, F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-41-2-426 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptMr. Chairman, Fellows of the College, Associates, Distinguished Guests and Friends:It seems but yesterday that the Board of Regents and the members of this College graciously accepted me as president, and entrusted to me the guardianship of its destinies, for good or for evil, till tomorrow doth end my sojourn in office.It has been a great honor and privilege and a deeply appreciated pleasure. Whatever good has been written into the archives has been due to the whole-hearted help which has been given by your Regents, your Governors and the members of this splendid organization. I do not... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: *Presented at the Third General Session, Chicago, April 7, 1954. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 August 1954Volume 41, Issue 2Page: 426-428KeywordsArchives ePublished: 1 December 2008 Issue Published: 1 August 1954 PDF downloadLoading ...
Abstract 2999: Troponin Profiles in Acute Decompensated Heart Failure: The Relevance of Change
Authors: Hammam D Zmily, Suleiman Daifallah, John D. Dingell, Sandip Zalawadiya, Jareer O Farah, Omaima Ali, Majd Ibrahim, Phillip Levy, Jalal K Ghali
Journal: Circulation (2009)

Introduction: Elevated cardiac troponin I (cTnI) level in patients with acute decompensated heart failure (ADHF) has been correlated with the severity of heart failure and worse outcomes. Limited i...
Cardiovascular Magnetic Resonance Imaging and Spectroscopy Detects Myocardial Fibrosis and Lipidosis in Patients with Dystrophinopathies, Even in the Presence of Normal Left Ventricular Ejection Fraction
Authors: Joseph J Suttie, Sairia Dass, Belen Franco, Rajarshi Banerjee, Peter Cox, Lowri Cochlin, Jane M Francis, Theodoros D Karamitsos, Matthew D Robson, Kieran Clarke, Jurgen E Schneider, Steffen E Petersen, Hugh Watkins, Stefan Neubauer
Journal: Circulation (2010)
Abstract 19214: Non Invasive Assessment of Myocardial Fibrosis in Human Atrial Fibrillation
Authors: Begõna Ĺopez, Eva Delṕon, Felipe Atienza, Arantxa Gonźalez, Jeśus Almendral, Javier D́iez
Journal: Circulation (2010)

Background and objective: Atrial fibrosis is common in patients with atrial fibrillation (AF) and causes abnormal conduction through the atria creating a substrate for AF. Therefore, the early dete...
Study of daytime sleepiness among tunnel workers on rotating schedule
Authors: Kiriakos Karkoulias, Dimosthenis Lykouras, Dimitrios Patouchas, Maria Sargianou, Fotios Sampsonas, Evanthia Faliagka, Athanasios Tsakalidis, Kostas Spiropoulos
Journal: European Respiratory Journal (2012)

Introduction : Working on shifts, and especially, on a night shift, influences the endogenous sleep regulation system leading to diminished sleep time and increased somnolence. This may be dangerous in some cases, especially in large scale constructions, such as tunnels.   Aims and objectives : The aim of our study was to examine whether sleep duration and daytime sleepiness differed between day and night shifts among tunnel workers.   Methods : In this study 42 male workers (during the last semester) in a tunnel construction were recruited and examined at workplace. They underwent spirometric control and they were asked to complete a questionnaire referring to demographic factors, status of health and the Epworth Sleepiness Scale.   Results : The workers present a mean age of 42 years old and a mean Body Mass Index (BMI) of 27.2 kg/m 2 . 69% of them were active smokers, while 31% have never tried smoking. Interestingly, 93% of the tunnel workers were consuming two coffees per day at least, while the remaining 7% were not drinking coffee at all. Almost one third of them reported alcohol consumption on a daily basis. Severe cardiologic, respiratory or endocrine disease was not reported among the participants and neither were depression and anxiety disorders. Our results showed that almost all the workers had gathered a score less than 10 in the Epworth Sleepiness Scale (a score of 10 or more is considered sleepy), except for two subjects in which statistical analysis did not reveal any statistically significant correlation between somnolence and the work schedule (p=0.88).   Conclusions : The rotating shift in a dark and demanding environment, as in the tunnel construction, does not play a significant role in daytime sleepiness.
Nephrogenic Systemic Fibrosis Manifesting a Decade After Exposure to Gadolinium
Authors: Krista N. Larson, Amy L. Gagnon, Melissa D. Darling, James W. Patterson, Thomas G. Cropley
Journal: JAMA Dermatology (2015)

Nephrogenic systemic fibrosis (NSF) is a fibrosing skin disorder that develops in patients with kidney failure and has been linked to exposure to gadolinium-containing contrast agents. The time between exposure to gadolinium and the initial presentation of NSF is typically weeks to months but has been documented to be as long as 3½ years. We report a case of NSF developing 10 years after exposure to gadolinium.A long-term hemodialysis patient was exposed to gadolinium several times between 1998 and 2004 during magnetic resonance angiography of his abdominal vessels and arteriovenous fistula. In 2014, he was seen at our clinic with new dermal papules and plaques. Biopsy of affected skin showed thickening of collagen, CD34+ spindle cells, and increased mucin in the dermis, supporting the diagnosis of NSF.The clinical history and histopathological features of this case support the diagnosis of NSF 10 years after exposure to gadolinium. Although the use of gadolinium contrast agents in patients with kidney failure has markedly decreased, patients with exposure to gadolinium years to decades previously may manifest the disease.
How to Guide Stent-Graft Implantation in Type B Aortic Dissection?
Authors: Dietmar H. Koschyk, Christoph A. Nienaber, Malgorzata Knap, Thomas Hofmann, Yskert V. Kodolitsch, Valeria Skriabina, Mohammed Ismail, Olaf Franzen, Tim C. Rehders, Christoph Dieckmann, Gunnar Lund, Hermann Reichenspurner, Thomas Meinertz
Journal: Circulation (2005)

Background— Despite growing interest in stent-graft implantation for type-B aortic dissection, there are no established recommendations to prepare and perform an implantation procedure. Methods and Results— We directly compared angiography (ANGIO), transesophageal echocardiography (TEE), and intravascular ultrasound (IVUS) intraprocedually before and after placement of 48 stent grafts in 42 consecutive patients (12 women, 61±11 years of age) with acute and chronic type-B aortic dissection for both usefulness and capability to guide aortic stent-graft implantation. Both IVUS and TEE are superior to ANGIO to identify multiple entries (52 and 43 versus 34; P &lt;0.005 each), to diagnose false-lumen slow flow after stent-graft implantation (32 and 31 versus 24; P &lt;0.005 each) and to detect incomplete stent apposition (18 and 16 versus 8; P &lt;0.005 each). In comparison with ANGIO, guide wire position over the entire length of the aorta was documented more frequently by TEE and IVUS (40 and 42 versus 25; P &lt;0.001 each). In 4 patients with abdominal extension of the dissection, only IVUS was able to accurately identify the false lumen over the entire length of the diseased aorta. TEE was superior to IVUS and ANGIO in the detection of endoleaks (5 versus 0 and 1; P &lt;0.05 each). Intraprocedural ANGIO, TEE, and IVUS had been performed without complications in all patients. Conclusions— TEE in conjunction with ANGIO appears to be advantageous and adds incremental information to safely guide stent-graft placement in type-B aortic dissection. Additional use of IVUS was found to be helpful in patients with complex anatomy and abdominal extension of the dissection.
siRNA screening at the functional level using a novel nano-immunoassay platform
Authors: David Voehringer, Wilhelm Lachnit, Arunashree Bhamidipati, Uyen Nguyen
Journal: Clinical Cancer Research (2007)

A53   The invention of small interfering RNA (siRNA) technology has provided a tool for understanding the function and relationships of proteins as well as strategies for drug development in disease. These tools are culled from libraries of potential candidate molecules through labor intensive screenings, usually employing western blot analysis of target protein levels. This approach becomes difficult if the target protein is expressed in small amounts or in rare cells. Here we present a novel nano-immunoassay platform (Firefly TM ) that has advantages over conventional approaches because it is automated, is extremely sensitive and is capable of analytically measuring protein from a few hundred cells. Neuronal growth factor (NGF) -stimulated neurons were treated with a panel of siRNA’s targeted at disrupting the NGF catalytic receptor trkA. siRNA’s that were specific for the trkA suppressed downstream ERK signaling. Control siRNA’s, which were targeted at proteins not involved in this pathway, exhibited no effect on ERK. The most striking finding of this study was that the effect of this siRNA was on the dual phosphorylation of ERK and not on the single phospho- forms. This type of result shows not only the usefulness of Firefly to measure the effectiveness of siRNA’s on target proteins, but also provides scientific insight into the functions of the proteins targeted (in this case: that trkA is responsible for the second phosphorylation event of ERK in NGF stimulation, but not the first).