tbuckley/cabot-search huggingface dataset:
Antigen responsiveness of the mature and generative B cell populations of aged mice.
Authors: D Zharhary, N R Klinman
Journal: The Journal of Experimental Medicine (1983)

The deficit of humoral immune responsiveness associated with aging was investigated at the level of individual antigen-specific B cells. It was found that mature dinitrophenyl (DNP)-responsive B cells isolated from the spleen of aged mice gave rise to clones of antibody-forming cells that were normal with respect to both the amount and relative affinity of anti-DNP antibody produced. However, although the proportion of immunoglobulin-bearing cells in the spleen of aged mice was normal, the proportion of cells that responded to T cell dependent DNP-specific stimulation (1.1 per 10(6) injected cells) was significantly lower than the proportion that responded when cells were obtained from the spleen of young mice (2.3 per 10(6) injected cells). To examine the origin of this diminution in antigen-responsive B cells, the responsiveness of precursor cells from the B cell generative pool isolated as the surface immunoglobulin negative (sIg-) cells within the bone marrow was evaluated. The frequency of DNP-responsive cells in both intact bone marrow cell suspensions and the sIg- subpopulation was not significantly different when such cells were isolated from aged vs. young individuals. Thus, it would appear that among the immunologic deficits associated with aging is a decrease in the proportion of antigen-responsive B cells, which is associated with maturation of B cell clones in the aged environment and occurs during the migration of cells from the bone marrow to the spleen.
Intrathoracic fundoplication for reflux stricture associated with short oesophagus
Authors: K Moghissi
Journal: Thorax (1983)

Intrathoracic fundoplication was carried out in 45 patients with reflux stricture associated with a short oesophagus after the stricture had been fully dilated at operation. There were two deaths in hospital (4·4%). The follow-up extended from one to 10 years. Two patients required dilatation and four others had symptoms of nausea and fullness, all for up to six months. Thirty-seven patients remained symptom free. No patient required further surgery. The procedure is recommended as a conservative surgical method for patients with reflux stricture associated with shortening of the oesophagus.
Alcohol consumption protects against arthritis development in seropositive arthralgia patients: Table 1
Authors: Lotte A van de Stadt, Dirkjan van Schaardenburg
Journal: Annals of the Rheumatic Diseases (2012)

Patients with arthralgia and auto-antibodies such as anticitrullinated protein antibodies and/or IgM-rheumatoid factor (seropositive) are at risk for developing rheumatoid arthritis (RA).1 RA is associated with lower alcohol intake, suggesting that alcohol consumption is protective for the development of RA.2,–,5 The proposed mechanism for this effect is that alcohol is immunosuppressive, possibly via intrinsic corticosteroid production. In animal …
Are We in a Medical Education Bubble Market?
Authors: David A. Asch, Sean Nicholson, Marko Vujicic
Journal: New England Journal of Medicine (2013)

Interview with Dr. David Asch on the cost and value of medical education. (00:00)Download Debt-to-income ratios for new physicians reveal the connection between what physicians can charge patients and what medical schools can charge students. If we aim to reduce the costs of health care, we need to reduce the costs of medical education.
Treatment in Depressive Illness
Authors: E. H. Hare
Journal: BMJ (1965)

years.I believe one of the greatest causes of this increase in deaf children is inadequate treatment with antibiotics.After twenty-four hours of oral penicillin the pain of otitis media disappears and the child feels better.This leads to a premature cessation of treat- ment.Too often children with measles are given antibiotics to prevent " complications," whereas they frequently mask otitis media.Because the ear drum is not red it does not mean all is well in the middle ear.The retracted drum, the white drum with a few vessels coursing over it, the yellow drum, the black drum, or the drum with a " hairline " across its middle all indicate underlying disease.These are all physical signs that are becoming more and more common but are infrequently recognized.Simple tests for hearing should always be carried out after treating otitis media.-Iam, etc.,
PERSISTENCE OF LEFT VENTRICULAR HYPERTROPHY IS ASSOCIATED WITH MARKEDLY WORSE OUTCOMES IN PATIENTS WITH LOWER ACHIEVED SYSTOLIC PRESSURE (?130 MM HG) DURING ANTIHYPERTENSIVE TREATMENT: THE LIFE STUDY
Authors: Peter M. Okin, Darcy A. Hille, Sverre E. Kjeldsen, Björn Dahlöf, Richard B. Devereux
Journal: Journal of the American College of Cardiology (2011)
Nondegradative Role of Atg5-Atg12/ Atg16L1 Autophagy Protein Complex in Antiviral Activity of Interferon Gamma
Authors: Seungmin Hwang, Nicole S. Maloney, Monique W. Bruinsma, Gautam Goel, Erning Duan, Lei Zhang, Bimmi Shrestha, Michael S. Diamond, Adish Dani, Stanislav V. Sosnovtsev, Kim Y. Green, Carlos Lopez-Otin, Ramnik J. Xavier, Larissa B. Thackray, Herbert W. Virgin
Journal: Cell Host & Microbe (2012)
RELATION OF THE ALLOXURIC BODIES TO GOUT OR A URIC ACID DIATHESIS.
Authors: T. B. FUTCHER
Journal: JAMA (1897)

In the German contributions on the studies of metabolism in various diseases which have appeared since 1895, one meets very frequently with the terms "alloxurkörper" or alloxuric bodies, and "alloxurbasen" or alloxuric bases. Especially is this the case in the study of the metabolism of gout. A brief explanation of the circumstances leading to the adoption of these terms may be of interest. In 1869 Miescher isolated a phosphorus-containing substance from the nuclei of pus cells to which Hoppe-Seyler gave the name nuclein. Previous to this date, xanthin and hypoxanthin had been known to chemists, but it was not until some time later that Kossel demonstrated that yeast nuclein could be made to yield phosphoric acid, hypoxanthin and an albuminous body, by the action of boiling water. Since then, hypoxanthin has been definitely proven to be derived from the nuclein of animal cells as well. In addition to hypoxanthin, four
Acute renal failure following oral sodium phosphate bowel preparation: a nationwide case-crossover study
Authors: Nam-Kyong Choi, Joongyub Lee, Yoosoo Chang, Ye-Jee Kim, Ju-Young Kim, Hong Song, Ju-Young Shin, Sun-Young Jung, Yukyong Choi, Jin-Ho Lee, Byung-Joo Park
Journal: Endoscopy (2014)

<b>Background and study aims:</b> Oral sodium phosphate (OSP) is a cleansing agent for colonoscopy. Recent reports have cited an increased risk of acute renal failure (ARF) in OSP bowel purgative users, but this risk remains under debate. This study was performed to evaluate the association between OSP and ARF in patients who underwent colonoscopy. <b>Patients and methods:</b> A population-based case-crossover study was conducted using the Korean Health Insurance Review and Assessment Service (HIRA) claims data from 1 January 2005 to 31 December 2009. The study population consisted of patients aged ≥ 50 years who underwent colonoscopies after an OSP prescription prior to their first hospitalization for ARF. For each patient, one hazard and four control periods were matched at specified time windows. Conditional logistic regression analysis was used to estimate the odds ratio (OR) and 95 % confidence interval (CI), adjusting for concomitant medications that could induce ARF. <b>Results:</b> A total of 1105 patients were included (54 % male). The adjusted ORs for ARF related to the use of OSP when applying the 1-, 2-, 4-, 8-, or 12-week time windows were 3.7 (95 %CI 2.37 – 5.67), 3.5 (95 %CI 2.45 – 4.89), 3.0 (95 %CI 2.30 – 3.95), 2.4 (95 %CI 1.93 – 2.96), and 2.0 (95 %CI 1.69 – 2.46), respectively. When adopting an 8-week time window, the adjusted OR was 2.5 (95 %CI 1.98 – 3.16) for the subgroup without chronic renal failure. <b>Conclusions:</b> The use of OSP was significantly associated with ARF both in patients with and without co-morbidities.
Future of the Safety Net Under Health Reform
Authors: Mitchell H. Katz
Journal: JAMA (2010)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Plasma Fas Ligand, an Inducer of Apoptosis, and Plasma Soluble Fas, an Inhibitor of Apoptosis, in Patients With Chronic Congestive Heart Failure
Authors: Kazuhiko Nishigaki, Shinya Minatoguchi, Mitsuru Seishima, Kiyoji Asano, Toshiyuki Noda, Norio Yasuda, Hirotake Sano, Hirokazu Kumada, Masao Takemura, Akio Noma, Tsutomu Tanaka, Sachiro Watanabe, Hisayoshi Fujiwara
Journal: Journal of the American College of Cardiology (1997)
Pulmonary Hypertension
Authors: Christopher F. Barnett, Priscilla Y. Hsue, Roberto F. Machado
Journal: JAMA (2008)

Modern health care has greatly increased longevity for patients with congenital hemolytic anemias (such as sickle cell disease and thalassemia) and human immunodeficiency virus (HIV) infection. It is estimated that 10% of patients with hemoglobinopathies and 0.5% of patients with HIV infection develop moderate to severe pulmonary hypertension. Pulmonary hypertension is a relentlessly progressive disease leading to right heart failure and death. Worldwide, there are an estimated 30 million patients with sickle cell disease or thalassemia and 40 million patients with HIV disease. Considering the prevalence of pulmonary vascular disease in these populations, sickle cell disease and HIV disease may be the most common causes of pulmonary hypertension worldwide. In this review, the available data on epidemiology, hemodynamics, mechanisms, and therapeutic strategies for these diseases are summarized. Because therapy is likely to reduce morbidity and prolong survival, efforts to screen, diagnose, and treat these patients represent a global health opportunity.
Health and the environment. Waste disposal: fresh looks at a rotting problem.
Authors: A Walker
Journal: BMJ (1991)

This patient had an abscess in the right groin and an abscess from an aortoenteric fistula secondary to an infected graft.He survived after removal of the infected aortic graft and bilateral axillofemoral grafting.This article has discussed the complications of peripheral arterial reconstruction, but the principles apply equally to reconstructions of other arteries such as carotid, renal, and mesenteric arteries.Arterial reconstructions are complex but they enable an independent mobile existence for many patients.The common problems are the most simple to manage.With prompt action the more serious problems can usually be resolved satisfactorily, leading to restoration of function.
How the Cows Turned Mad
Authors: M. Otto
Journal: BMJ (2003)

The bovine spongiform encephalopathy (BSE) crisis has had a major impact on health politics, the scientific landscape, and the economy over the past 15 years. Panic over BSE seems to have been driven by a lack of knowledge and contradictory information about the pathogen.

Maxime Schwartz, former head of the Pasteur Institute in Paris, has …
Development of Crohn disease in a patient on etanercept for psoriasis
Authors: K. Ahmad, S. Rogers
Journal: British Journal of Dermatology (2007)

Journal Article Development of Crohn disease in a patient on etanercept for psoriasis Get access K. Ahmad, K. Ahmad Department of Dermatology, St Vincent's University Hospital, Dublin 4, Ireland E‐mail: kashifaa2002@gmail.com Search for other works by this author on: Oxford Academic Google Scholar S. Rogers S. Rogers Department of Dermatology, St Vincent's University Hospital, Dublin 4, Ireland E‐mail: kashifaa2002@gmail.com Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 157, Issue 2, 1 August 2007, Page 396, https://doi.org/10.1111/j.1365-2133.2007.08009.x Published: 01 August 2007
Implication of Serum Neutrophil Gelatinase-Associated Lipocalin Levels in Patients Who Underwent First-time Diagnostic Coronary Angiography
Authors: Ahmet Bacaksız, Ziya Ismailoglu, Ahu Sarbay, Sitki Kucukbuzcu, Seref Kul, Abdurrahman Tasal, Osman Sonmez, Ercan Erdogan, Murat Turfan, Mehmet Akif Vatankulu, Parviz Jafarov, Mehmet Ergelen, Omer Goktekin
Journal: Journal of the American College of Cardiology (2013)
JM2, encoding a fork head–related protein, is mutated in X-linked autoimmunity–allergic disregulation syndrome
Authors: Talal A. Chatila, Frank Blaeser, Nga Ho, Howard M. Lederman, Constantine Voulgaropoulos, Cindy Helms, Anne M. Bowcock
Journal: Journal of Clinical Investigation (2000)

X-linked autoimmunity-allergic disregulation syndrome (XLAAD) is an X-linked recessive immunological disorder characterized by multisystem autoimmunity, particularly early-onset type 1 diabetes mellitus, associated with manifestations of severe atopy including eczema, food allergy, and eosinophilic inflammation. Consistent with the allergic phenotype, analysis of two kindreds with XLAAD revealed marked skewing of patient T lymphocytes toward the Th2 phenotype. Using a positional-candidate approach, we have identified in both kindreds mutations in JM2, a gene on Xp11.23 that encodes a fork head domain-containing protein. One point mutation at a splice junction site results in transcripts that encode a truncated protein lacking the fork head homology domain. The other mutation involves an in-frame, 3-bp deletion that is predicted to impair the function of a leucine zipper dimerization domain. Our results point to a critical role for JM2 in self tolerance and Th cell differentiation.
A DOUBLE HOOK FOR USE IN ADVANCEMENT OPERATIONS.
Authors: C. F. CLARK
Journal: JAMA (1900)

This instrument is intended to simplify the operation for advancement of the recti muscles and to make it possible to regulate with certainty the amount of shortening obtained. It consists of a small hook, the shank of which is embedded in the anterior surface of a larger one, and the arm of which passes between the blades of the forked arm of the larger one. By means of a milled screw and a ratchet the single hook may be projected beyond and between the blades of the double one, so as to take up a fold of the tendon and draw it up between the blades to the desired height, when the sutures may be introduced and the superfluous fold cut off, if so desired. The instrument is made with a detachable handle, so that during the suturing the aid of an assistant may be dispensed with. I have found
A NEW FORCEPS
Authors: Charles S. Venable
Journal: JAMA (1913)

I have had made by Kny-Scherer a new instrument which may be of interest to readers of The Journal. It is a combined pair of scissors and mouse-toothed forceps. It is to be used by the first assistant in picking up structures to be sutured, drawing the needle through after it has pierced the structure and cutting the suture at the desired moment. It will be seen at a glance that this obviates the use of two and possibly three instruments to accomplish the same thing—namely, a thumb-forceps, a hemostat and a pair of scissors. 205 East Myrtle Street.
Lupus-type illness associated with labetalol.
Authors: I D Griffiths, J Richardson
Journal: BMJ (1979)

<h3>ABSTRACT</h3> Chimeric antigen receptor (CAR) costimulatory domains steer the phenotypic output of therapeutic T cells. In most cases these domains are derived from native immune receptors, composed of signaling motif combinations selected by evolution. To explore if non-natural combinations of signaling motifs could drive novel cell fates of interest, we constructed a library of CARs containing ∼2,300 synthetic costimulatory domains, built from combinations of 13 peptide signaling motifs. The library produced CARs driving diverse fate outputs, which were sensitive to motif combinations and configurations. Neural networks trained to decode the combinatorial grammar of CAR signaling motifs allowed extraction of key design rules. For example, the non-native combination of TRAF- and PLCγ1-binding motifs was found to simultaneously enhance cytotoxicity and stemness, a clinically desirable phenotype associated with effective and durable tumor killing. The neural network accurately predicts that addition of PLCγ1-binding motifs improves this phenotype when combined with TRAF-binding motifs, but not when combined with other immune signaling motifs (e.g. PI3K-or Grb2-binding motifs). This work shows how libraries built from the minimal building blocks of signaling, combined with machine learning, can efficiently guide engineering of receptors with desired phenotypes. <h3>Graphical Abstract</h3>
Low-dose dithranol treatment and tape stripping induce tolerance to dithranol in a mouse ear oedema model
Authors: L. Keme'ny, A'. Farkas, A. Dobozy
Journal: British Journal of Dermatology (2002)

Journal Article Low‐dose dithranol treatment and tape stripping induce tolerance to dithranol in a mouse ear oedema model Get access L. Keme´ny, L. Keme´ny Department of Dermatology, Faculty of General Medicine, University of Szeged, Szeged, HungaryDermatological Research Group of the Hungarian Academy of Sciences, PO Box 427, 6701 Szeged, Hungary Dr Lajos Kemény. E‐mail: kl@derma.szote.u‐szeged.hu Search for other works by this author on: Oxford Academic Google Scholar A´. Farkas, A´. Farkas Department of Dermatology, Faculty of General Medicine, University of Szeged, Szeged, Hungary Search for other works by this author on: Oxford Academic Google Scholar A. Dobozy A. Dobozy Department of Dermatology, Faculty of General Medicine, University of Szeged, Szeged, HungaryDermatological Research Group of the Hungarian Academy of Sciences, PO Box 427, 6701 Szeged, Hungary Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 146, Issue 5, 1 May 2002, Pages 764–769, https://doi.org/10.1046/j.1365-2133.2002.04663.x Published: 01 May 2002 Article history Accepted: 25 October 2001 Published: 01 May 2002
Physicochemical, Cytotoxic, and Dermal Release Features of a Novel Cationic Liposome Nanocarrier
Authors: Maura Carboni, Angela M. Falchi, Sandrina Lampis, Chiara Sinico, Maria L. Manca, Judith Schmidt, Yeshayahu Talmon, Sergio Murgia, Maura Monduzzi
Journal: Advanced Healthcare Materials (2012)

Abstract A novel cationic liposome nanocarrier, having interesting performance in topical drug delivery, is here presented and evaluated for its features. Two penetration enhancers, namely monoolein and lauroylcholine chloride, are combined to rapidly formulate (15 min) a cationic liposome nanostructure endowed of excellent stability (&gt;6 months) and skin penetration ability, along with low short‐term cytotoxicity, as evaluated via the MTT test. Cytotoxicity tests and lipid droplet analysis give a strong indication that monoolein and lauroylcholine synergistically endanger long‐term cells viability. The physicochemical features, investigated through SAXS, DLS, and cryo‐TEM techniques, reveal that the nanostructure is retained after loading with diclofenac in its acid (hydrophobic) form. The drug release performances are studied using intact newborn pig skin. Analysis of the different skin strata proves that the drug mainly accumulates into the viable epidermis with almost no deposition into the derma. Indeed, the flux of the drug across the skin is exceptionally low, with only 1% release after 24 h. These results validate the use of this novel formulation for topical drug release when the delivery to the systemic circulation should be avoided.
Solid-supported reagents in organic synthesis
Authors: David H. Drewry, Diane M. Coe, Steve Poon
Journal: Medicinal Research Reviews (1999)

The current interest in solid-phase organic synthesis has led to a renewed interest in a complementary technique in which solid supported reagents are used in solution phase chemistry. This technique obviates the need for attachment of the substrate to a solid-support, and enables the chemist to monitor the reactions using familiar analytical techniques. The purpose of this review is to increase awareness of the wide range of useful transformations which can be accomplished using solid-supported reagents. © 1999 John Wiley & Sons, Inc. Med Res Rev 19, 97–148, 1999.
Paralytic poliomyelitis in England and Wales, 1985-91.
Authors: R. Joce, D. Wood, D. Brown, N. Begg
Journal: BMJ (1992)

To ascertain all cases of paralytic poliomyelitis in England and Wales during 1985-91 and to determine the source of infection in each case.Descriptive study of cases reported between 1985 and 1991.All health districts in England and Wales.Patients normally resident in England and Wales whose clinical features were consistent with paralytic poliomyelitis or with laboratory evidence of recent poliovirus infection and compatible symptoms.Clinical, epidemiological, and laboratory features in identified cases.Of 54 suspected cases of poliomyelitis, 33 were excluded, leaving 21 cases, of which 13 were vaccine associated (nine recipient and four contact) cases, five were imported cases, and three were cases whose source of infection was unknown. No cases due to indigenous wild polioviruses were identified; two were imported cases due to wild viruses. One patient died during the acute phase of the illness, and two children with previously unrecognised severe congenital immune deficiency died between one and two months after the onset of paralysis after the first or second dose of oral polio vaccine. The estimated risk of vaccine associated paralysis is 1.46 per million for the first dose, 0.49 for the second, zero for the third and fourth doses, and 0.33 for the fifth.Indigenous wild poliovirus seems to have been eradicated, although wild virus may be imported; improved surveillance of suspected cases including immediate notification and characterisation of the virus to ensure that eradication is maintained is essential.
Commentary: Knowledge is not always power
Authors: N. Mays
Journal: BMJ (2010)

Tunis and Pearson describe the objections raised by critics to the inclusion of comparative effectiveness research as part of President Obama’s health reforms and the concessions made so that the Patient-Centred Outcomes Research Institute could be included in the final legislation.1 Despite (possibly because of) the compromises made, the authors believe that the new institute “will prove to be enduring and highly influential.” Their belief seems to rest on the following frail foundations:
Pregnancy and Lactation Changes in Fibro-adenoma of Breast
Authors: C. F. Geschickter, D. Lewis
Journal: BMJ (1938)

The fibro-adenoma is the most common tumour of the breast occurring in young women in the child-bearing period.The firm character of the lesion, the definite encapsulation, and the slow growth over a period of years make the clinical diagnosis relatively easy.The rapid growth of fibro-adenoma during pregnancy and the cystic enlargement during lactation are less well-known features.