tbuckley/cabot-search huggingface dataset:
Portrait of a Halberdier (Francesco Guardi?)
Authors: M. Therese Southgate
Journal: JAMA (2003)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Estimate of human gene number provided by genome-wide analysis using Tetraodon nigroviridis DNA sequence
Authors: Hugues Roest Crollius, Olivier Jaillon, Alain Bernot, Corinne Dasilva, Laurence Bouneau, Cécile Fischer, Cécile Fizames, Patrick Wincker, Philippe Brottier, Francis Quétier, William Saurin, Jean Weissenbach
Journal: Nature Genetics (2000)
Some Toxaemias of Animals Due to Anaerobic Organisms: A Comparative Pathological Study of recent work with particular reference to the Toxaemia of Intestinal Obstruction in man
Authors: H. A. Woodruff
Journal: BMJ (1936)

4o~rE 29~1~3CTNFth6S my Aqualities, seems theoretically the most rational type to employ, but it soon loses its effect owing,to an inherent compensatory ability of the skin to assume a per-manent alkaline reaction.On the other hand, the use. of hydro- chloric, lactic, tartaric, carbolic, and other acids, the acid effect of which is due rather to their molecules than to their hydrogen-ion content, tends later to become irritating.In view of these facts, and after reading an article by Armstrong in the British Medical Journal which described the relief obtained by the use of lemon juice in vesicular dermatoses of external irritant origin, I decided to try its effect on those of mycotic origin.For the last four months I have compared the results of therapeutic concentrations of some of the aforemen- tioned acids with those obtained by the use of lemon juice, which were definitely superior.Although I have not treated a sufficient number of cases to dra-w any accurate conclusions it would seem that the vitamin content in fresh lemon juice might play some minor part in addition to the citric acid content.This acid has the
Factors associated with cognitive dysfunction in COPD patients hospitalised with exacerbations
Authors: Andrew Tappouni, Mohani Bajaj, Michael Tumilty, James Dodd, Paul Jones, Emma Baker
Journal: European Respiratory Journal (2014)

Introduction   COPD patients awaiting hospital discharge following exacerbation have cognitive impairment, which is worse than that seen in stable COPD patients and doesn9t improve over 3 months [Dodd et al Chest 144:119-27].   Aims   We determined factors associated with cognitive impairment in COPD during acute exacerbation and examined associations between cognition and time from hospital admission.   Methods   COPD patients with exacerbations without known neurological disease or alcohol dependence were recruited from hospital wards. Participants completed Montreal Cognitive Assessment (MoCA), Hospital Anxiety and Depression score (HAD), COPD Assessment Test (CAT) and underwent spirometry and clinical record review.   Results   20 COPD patients (age 73±10 years, 40% male, FEV 1  42±19% predicted, 3.1±3.4 days from admission) had MoCA 21.0±5.8. Sixteen (80%) had cognitive impairment (MoCA l26/30). MoCA decreased with increasing age (r=-0.59, p=0.006), Charlson Index (r=-0.69, p=0.001) and random blood glucose (r=-0.57, p=0.034) and increased with time from admission (r=0.56, p=0.010). MoCA was not significantly associated with smoking (pack years), airflow obstruction, acute illness severity, C-reactive protein, CAT or HAD. On multiple linear regression, age, Charlson index, random glucose and time till assessment were not independently associated with MoCA.   Conclusions   Hospitalised patients with COPD exacerbations have considerable cognitive impairment, associated with age and comorbidity, rather than smoking load, airflow obstruction or exacerbation severity. However, association with time from admission indicates acute worsening of cognition with exacerbation that initially improves with recovery.
Expression profiling of Th17 cell activators revealed elevation of STAT-3 in progressing sarcoidosis
Authors: Regina Fillerova, Eva Kriegova, Tereza Tomankova, Frantisek Mrazek, Monika Zurkova, Vitezslav Kolek, Martin Petrek
Journal: European Respiratory Journal (2011)

Sarcoidosis is a Th1/Th17 multisystem inflammatory disorder of unknown aetiology. Although Th17 cells have been implicated in sarcoidosis and its progression, there is limited information about the molecules involved in the Th17 immune response in sarcoidosis and its phenotypes.  We, therefore, investigated, mRNA expression of Th17 pathway activators (IL-6, IL-21, IL-23, TGFbeta, RORC, STAT-3) together with the cytokines produced by Th17 cells (IL-17A, IL-17F, IL-22) by quantitative RT-PCR in bronchoalveolar (BAL) cells from 77 sarcoidosis patients (S) and 20 control subjects (C); subanalysis was performed in sarcoid phenotypes.  Of studied Th17 activators, IL-6 (mean S/C; 0.37/0.04,  p =0.0001), IL-21 (0.002/0.001,  p =0.001), IL-23 (0.06/0.02,  p =0.001), TGFbeta (0.86/0.51,  p =0.02) and RORC (0.06/0.02,  p =0.0002) were up-regulated in sarcoidosis vs. controls. Expression of Th17 cytokines did not differ between sarcoidosis and controls ( p> 0.05). The expression profiling in remitting (n=27) and progressing (n=40) sarcoidosis, as assessed by the disease outcome after 2 years, revealed elevation of STAT-3 in progressing sarcoidosis ( p =0.01).  In conclusion, increased expression of Th17 activators (IL-6, IL-21, IL-23, TGFbeta, RORC) was observed in sarcoid BAL cells irrespective of clinical phenotype. Enhanced expression of STAT-3, an essential regulator of Th17 cells, was detected in patients with progressing sarcoidosis. Further studies on the role of STAT-3 and Th17 cells in the progression towards the fibrosis in sarcoidosis are needed.  Grant support: IGA MZ CR NS/11117, IGA MZ CR NS/10267, PU LF_2010_008.
A PK/PD and Systems Biology Approach for Anti-angiogenic Drug Discovery
Authors: Jonathan Yingling
Journal: Clinical Cancer Research (2007)

CN06-02   Angiogenesis is one of the key biological processes in tumor growth and metastasis. Clinical validation of angiogenesis as a therapeutic target fueled the burgeoning pipeline of small molecule and biologics which target this mechanism. Yet, we are still at the beginning of understanding the diverse ligands and receptors involved in this process. We are interested both in developing novel therapeutics based on our targeted PK/PD strategy and novel systems biology approaches to better understand the angiogenic process and its role in tumor progression.  We have developed a systems biology approach involving a co-culture assay of endothelial cells and fibroblasts. High content image analysis allows discrimination of complex morphological features during in vitro angiogenesis. ECs form cord like capillary structure when co-cultured with fibroblasts in vitro over 9 to 12 days. The EC competence and the fibroblast supportiveness of cord formation are highly cell passage dependent. We performed complementary gene expression analysis on both EC and fibroblasts under optimal and suboptimal conditions to model angiogenesis control in vitro. We established an interactome from differentially expressed genes (DEGs) in this co-culture system. The interactome consists of 26000 interactions and represents a scale free network. Major signaling pathways involved in angiogenesis regulation are mapped in this network along with feedback and resistance mechanisms and oncogene and tumor suppressor genes. A phenotypic drug discovery effort has been initiated to identify novel small molecule inhibitors of angiogenesis utilizing the co-culture system and efforts are underway to enable in vivo characterization of the molecular mechanisms of anti-angiogenesis of compounds identified in this screen. Details of our chemo- and bio-informatic approach to studying angiogenesis will be presented.
Abstract 12267: The Alpha1 Isoform of Soluble Guanylate Cyclase Regulates Cardiac Contractility but is not Required for Cardioprotective Signaling
Authors: Patrick Y Sips, Peter Brouckaert, Fumito Ichinose
Journal: Circulation (2010)

Background: Soluble guanylate cyclase (sGC) stimulation is an important signaling event in various cardioprotective pathways, with potential clinical applications in cardiac critical care and resuscitation. The sGCα subunit, which binds to the common sGCβ1 subunit, exists in 2 different isoforms, sGCα1 and sGCα2, but their relative physiological roles remain unknown. Methods: We studied Langendorff-perfused isolated hearts of genetically engineered mice lacking functional sGCα1 (sGCα1KO mice), which is the predominant isoform in the heart. We subjected the hearts to 40 min of global ischemia and 1 hour of reperfusion, with or without ischemic preconditioning (IPC) to elicit cardioprotection. Results: Deficiency of sGCα1 enhanced both inotropy and lusitropy in isolated hearts, indicating an important role for this isoform in regulating basal myocardial contractility. Surprisingly, cardioprotection by IPC led to a similar reduction in infarct size in both wild-type (WT) and sGCα1KO hearts (from 41 ± 4% to 2...
Giving HIV the Silent Treatment and Other Strategies Examined at Conference
Authors: Joan Stephenson
Journal: JAMA (2003)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Abstract 1177: Effects of Stress Reduction on Clinical Events in African Americans With Coronary Heart Disease: A Randomized Controlled Trial
Authors: Robert Schneider, Sanford Nidich, Jane Morley Kotchen, Theodore Kotchen, Clarence Grim, Maxwell Rainforth, Carolyn Gaylord King, John Salerno
Journal: Circulation (2009)

Introduction: Atherosclerotic cardiovascular disease (CVD) is the leading cause of death in the US. African Americans suffer from disproportionately high rates of mortality and morbidity from CVD. ...
Abstract 15857: Aortic Valve Calcification is Reduced by COX2 Inhibition
Authors: Elaine E Wirrig, Robert B Hinton, Katherine E Yutzey
Journal: Circulation (2014)

Calcific aortic valve disease (CAVD) is a significant cause of morbidity and mortality in the United States and is characterized by calcific nodule formation and stenosis of the valve. The molecular mechanisms underlying valve calcification are poorly understood and surgical replacement remains the most common treatment option for severe aortic stenosis. Molecular mechanisms and treatment strategies for CAVD were examined in klotho-deficient mice, which develop aortic valve (AoV) calcification in association with accelerated aging. Through a microarray screen comparing AoV tissues from klotho-deficient and wild type mice, the gene encoding COX2 (cyclooxygenase 2/ ptgs2) was observed to have significantly increased expression in calcified AoV tissues of klotho-deficient mice. Since COX2 activity contributes to bone differentiation and homeostasis, we hypothesize that COX2 activity also contributes to valve calcification through induction of osteogenic mechanisms. In klotho-deficient mice, COX2 expression is increased throughout regions of valve calcification and is induced in the valvular interstitial cells (VICs) prior to the presence of detectable calcification. Similarly, COX2 expression is increased in human diseased AoVs in regions of valve calcification. Treatment of cultured porcine aortic VICs with osteogenic media induces bone marker gene expression, which is blocked by inhibition of COX2 activity, supporting a therapeutic strategy of COX2 inhibition in CAVD. In vivo, genetic loss of function of COX2 cyclooxygenase activity partially rescues AoV calcification in klotho-deficient mice. Moreover, pharmacologic inhibition of COX2 activity in klotho-deficient mice via celecoxib-containing diet reduces AoV calcification and blocks bone marker gene expression. Thus, COX2 expression is upregulated in CAVD and inhibition of COX2 activity is an effective treatment for reducing AoV calcification in klotho-deficient mice. The data presented show for the first time that COX2 activity contributes to bone marker gene induction and AoV calcification and that COX2 inhibition effectively reduces valve calcification in a mouse model of CAVD.
gp130, The Cytokine Common Signal-Transducer of Interleukin-6 Cytokine Family, Is Downregulated in T Cells In Vivo by Interleukin-6
Authors: Xue-Jie Wang, Tetsuya Taga, Kanji Yoshida, Mikiyoshi Saito, Tadamitsu Kishimoto, Hitoshi Kikutani
Journal: Blood (1998)
All Night Diners
Authors: Lynne Lamberg
Journal: JAMA (2003)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Abstract 1823: Novel regulation of Jagged1 by ErbB2 in breast cancer: implications for anti-ErbB2 therapy
Authors: Clodia Osipo, Kinnari Pandya, Debra Wyatt
Journal: Cancer Research (2014)

Abstract We have demonstrated that Notch1 is required for trastuzumab resistance in ErbB2 positive breast cancer. This indicates that ErbB2 suppresses Notch1 in breast cancer and therapeutic intervention targeting ErbB2 might have an unintended consequence which is aberrant up regulation of Notch1 which is a breast oncogene. However, the mechanism of action by which ErbB2 restricts Notch1 activation is unknown. In this current study, we investigated the role of cis- and trans-activation of Notch signaling by Notch ligands which are developmentally conversed to tightly regulate Notch activation. To address this hypothesis, we performed co-culture studies using fibroblasts expressing no Notch ligands or over-expressing human Jagged1 or Deltalike1 and ErbB2 positive breast cancer cells. We performed flow cytometry to isolate breast cancer cells after co-culture and extracted RNA to measure expression of Notch gene targets as a measure of Notch activity. The results showed that trastuzumab, Lapatinib, or ErbB2 knockdown increased overall Notch activition. Similarly, Co-culture with Jagged1-expressing fibroblasts increased overall Notch activation. However, Knocked down of Jagged1 in the breast cancer cells had little effect on ligand-induced Notch activation relieving the possibility of cis-inhibition. In contrast, Jagged1 knocked down abrogated trastuzumab-induced Notch activation in the breast cancer cells. These results suggest that ErbB2 might restrict Notch activation by preventing Jagged1-mediated trans activation of Notch and not by promoting cis-inhibition. Confocal immunofluorescence showed that Jagged1 is localized with Notch1 when ErbB2 is hyperactive but is trafficked to the cell surface in response to trastuzumab. K44ADynamin abrogated Jagged1 expression on the cell surface as measured by IF and surface biotinylation studies. Furthermore, K44ADynamin expression abrogated trastuzumab-induced Notch1 activation. Importantly, we measured growth consequences of Jagged1-mediated Notch activation in response to trastuzumab and found that Jagged1 is necessary for survival of ErbB2 positive breast cancer cells and trastuzumab resistance as measured by cell cycle analysis and Annexin V staining. These results taken together indicate that ErbB2 restricts Notch by limiting Jagged1-mediated trans-activation. Citation Format: Clodia Osipo, Kinnari Pandya, Debra Wyatt. Novel regulation of Jagged1 by ErbB2 in breast cancer: implications for anti-ErbB2 therapy. [abstract]. In: Proceedings of the 105th Annual Meeting of the American Association for Cancer Research; 2014 Apr 5-9; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2014;74(19 Suppl):Abstract nr 1823. doi:10.1158/1538-7445.AM2014-1823
GMC reviews burden of proof in professional misconduct cases
Authors: Clare Dyer
Journal: BMJ (2000)

The General Medical Council may adopt a lower standard of proof when considering allegations of serious professional misconduct. The regulatory body for doctors registered in the United Kingdom, came under pressure to review its practices last July when the NHS Plan for England said that the council should explore the introduction of the civil standard of proof and other reforms “if it is to generally protect patients.”

Jean Ritchie QC, in the report of her inquiry into system failures in the case of the gynaecologist Rodney Ledward, …
EARLY DETECTION OF PRIMARY HEPATOCELLULAR CARCINOMA BY SCREENING FOR ALPHA-FETOPROTEIN IN HIGH-RISK FAMILIES
Authors: WilliamL. Heyward, ThomasR. Bender, Steven Kilkenny, KathyT. Kline, AnneP. Lanier, BrianJ. McMahon, TedR. Paprocki, DianaR. Silimperi, JamesE. Maynard
Journal: The Lancet (1983)
Outbreak of legionnaires' disease in the United Kingdom
Authors: R. S Bhopal
Journal: BMJ (2002)

<h3>Abstract</h3> Overabundant, free-roaming dog populations are associated with risks to public health, livestock losses, wildlife conservation, and dog health and welfare. Dog population management is conducted to mitigate these issues. Assessing dog population management strategies is important to determine their effectiveness, efficiency, and long-term impact. It is essential to also determine how the behaviour and outlook of local communities may influence the efficacy of dog population management. This study aimed to determine public attitudes towards free-roaming dogs and their management and describe dog ownership practices in three European countries using an online questionnaire survey. This study found that most surveyed respondents wanted to see a reduction in free-roaming dog numbers, and felt that this should be achieved through sheltering, catch-neuter-release, and by controlling the breeding of owned dogs. This questionnaire also identified significant associations between public attitudes and dog ownership practices with gender, religious beliefs, age, education level, reason for dog ownership, previous experience with free-roaming dogs, and country of residence. Respondents who identified as: (i) being male, (ii) holding religious beliefs, (iii) owning dogs for practical reasons, (iv) being young, and (v) having no schooling or primary education had a lower probability of neutering and a higher probability of allowing dogs to roam. Respondents who identified as: (i) being female, (ii) feeling threatened by free-roaming dogs, (iii) being older, and (iv) having more education had a higher probability of answering that an increase in free-roaming dog numbers should be prevented. These findings can help to inform future dog population management interventions in these countries and highlight the importance of considering local public attitudes and dog ownership practices in the development of effective dog population management approaches. Including these social factors will ensure that both the community and organisations involved in dog population management work cohesively towards a shared goal.
Dog allergen in indoor air and dust during dog shows
Authors: H. Mussalo‐Rauhamaa, K. Reijula, M. Malmberg,, S. Mäkinen‐Kiljunen, T. Lapinlampi
Journal: Allergy (2001)

Background and methods: Dog dander is one of the most important indoor allergens in Nordic countries. Due to the population flow into cities, the number of dogs in urban areas has increased. Dog allergens can be found practically everywhere indoors. We measured allergen content in indoor air and dust during dog shows. Results: In facilities used for dog shows, the dog allergen content was exceptionally high, up to 2 100 000 ng Can f 1/g dust, but it can be reduced by proper cleaning. The efficiency of cleaning will remain poor if furniture and textiles are not cleaned or the distribution of airborne allergen cannot be prevented. Conclusions: Dog shows should not be held in public facilities, such as schools, where a significant proportion of occupants are hypersensitive to dog allergens and may therefore suffer symptoms due to the exposure to dog dander.