PATHOGENESIS OF COCCIDIOIDOMYCOSIS WITH SPECIAL REFERENCE TO PULMONARY CAVITATION
Authors: C E SMITH, R R BEARD, M T SAITO
Journal: Annals of Internal Medicine (1948)

Article1 October 1948PATHOGENESIS OF COCCIDIOIDOMYCOSIS WITH SPECIAL REFERENCE TO PULMONARY CAVITATIONCHARLES EDWARD SMITH, M.D., RODNEY RAU BEARD, M.D., MARGARET TAIKO SAITO, A.B.CHARLES EDWARD SMITH, M.D.Search for more papers by this author, RODNEY RAU BEARD, M.D.Search for more papers by this author, MARGARET TAIKO SAITO, A.B.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-29-4-623 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptIt is now accepted that human infections ofCoccidioides immitisare usually acquired by inhaling the chlamydospores and arthrospores of the fungus. Occasionally the portal of entry may be by abrasions or lacerations.8After an incubation period ranging from one to three weeks, symptoms develop in approximately 40 per cent of infected males.37However, three-fifths of the infections are completely asymptomatic. The pneumonic or respiratory symptoms which occur in two-fifths are of varying degrees of severity. Among females an increased frequency of erythema nodosum results in a somewhat higher proportion of clinically manifest disease. This erythema nodosum is a complication...Bibliography1. BAKERMRAKSMITH EEEMCE: The morphology, taxonomy and distribution of Coccidioides immitis Rixford and Gilchrist, 1896, Farlowia, 1943, i, 199-244. Google Scholar2. BECKDICKSONRIXFORD MDECE: Coccidioidal granuloma, California State Department of Public Health Bulletin 57, 1931. Google Scholar3. BRUNN H: Personal communication. Google Scholar4. CHERRYBARTLETT CBAG: The diagnosis of acute Coccidioides immitis infections, Bull. U. S. Army Med. Dept., 1946, v, 190-193. Google Scholar5. CLELAND RS: Personal communication. Google Scholar6. COLBURN JR: Roentgenological types of pulmonary lesions in primary coccidioidomycosis, Am. Jr. Roentgenol. and Rad. Therap., 1944, li, 1-8. Google Scholar7. DENENHOLZCHENEY EJG: Diagnosis and treatment of chronic coccidioidomycosis, Arch. Int. Med., 1944, lxxiv, 311-330. CrossrefGoogle Scholar8. DICKSON EC: Coccidioides infection. Part I., Arch. Int. Med., 1937, lix, 1029-1044. CrossrefGoogle Scholar9. DICKSON EC: Valley fever, Calif. and West. Med., 1937, xlvii, 151-155. Google Scholar10. DICKSONGIFFORD ECMA: Coccidioides infection (coccidioidomycosis); II, Arch. Int. Med., 1938, lxii, 853-871. CrossrefGoogle Scholar11. FARNESSMILLS OJCW: A case of primary infection with coccidioides in lung with cavity formation and healing, Am. Rev. Tuberc., 1939, xxxix, 266-273. Google Scholar12. FINEGAN TC: Personal communication. Google Scholar13. FORBUSBESTEBREUTJE WDAM: Coccidioidomycosis; a study of 95 cases of the disseminated type with special reference to the pathogenesis of the disease, Mil. Surg., 1946, xcix, 653-719. Google Scholar14. GIFFORD MA: Annual Report Kern County Health Department for the Fiscal Year July 1, 1935, to June 30, 1936, pp. 22-23. Google Scholar15. GIFFORDBUSSDOUDS MAWCRJ: Annual Report Kern County Health Department for the Fiscal Year July 1, 1936, to June 30, 1937, pp. 39-54. Google Scholar16. GOLDSTEINLOUIE DMS: Primary pulmonary coccidioidomycosis, report on an epidemic of 75 cases, War Med., 1943, iv, 299-317. Google Scholar17. HOUCK GW: Personal communication. Google Scholar18. JAMISON HW: A roentgen study of chronic pulmonary coccidioidomycosis, Am. Jr. Roentgenol. and Rad. Therap., 1946, lv, 396-412. Google Scholar19. JAMISONCARTER HWRA: The roentgen findings in early coccidioidomycosis, Radiology, 1947, xlviii, 323-332. CrossrefGoogle Scholar20. KABZA TG: Personal communication. Google Scholar21. KURZLOUD ERNW: Coccidioidomycosis in New England, New England Jr. Med., 1947, ccxxxvii, 610-616. CrossrefGoogle Scholar22. LEE RV: Coccidioidomycosis in the Western Flying Training Command, Calif. and West. Med., 1944, lxi, 133-134. Google Scholar23. LEENIXONJAMISON RVNHW: Syllabus on coccidioidomycosis. Coccidioidomycosis control program for the A.A.F.W.F.T.C., Prepared by Headquarters Army Air Forces Western Flying Training Command, Office of the Surgeon, Santa Ana, California (various editions 1942-1944). Google Scholar24. MAHON HW: Personal communication. Google Scholar25. MARPLE CD: Personal communication. Google Scholar26. NALLS WL: Personal communication. Google Scholar27. PEERSHOLMANSMITH RAEFCE: Pulmonary coccidioidal disease, Am. Rev. Tuberc., 1942, xlv, 723-740. Google Scholar28. POWERSSTARKS RADJ: Acute (primary) coccidioidomycosis: Roentgen findings in a group "epidemic," Radiology, 1941, xxxvii, 448-453. CrossrefGoogle Scholar29. RIFKINFELDMANHAWESGORDON HDJLELE: Coexisting tuberculosis and coccidioidomycosis, Arch. Int. Med., 1947, lxxix, 381-390. CrossrefGoogle Scholar30. ROGERS WL: Personal communication. Google Scholar31. ROSENBERGERWHITINGSMITH HGEGCE: Clinical manifestations in 753 hospitalized cases of coccidioidomycosis (to be published). Google Scholar32. ROSENTHALROUTIEN SRJB: The infectiousness of coccidioidomycosis, Science, 1946, civ, 479. CrossrefGoogle Scholar33. ROSENTHALROUTIEN SRJB: Contagiousness of coccidioidomycosis. An experimental study, Arch. Int. Med., 1947, lxxx, 343-357. CrossrefGoogle Scholar34. SMART RH: Personal communication. Google Scholar35. SMITH CE: The epidemiology of acute coccidioidomycosis with erythema nodosum ("San Joaquin" or "Valley Fever"), Am. Jr. Pub. Health, 1940, xxx, 600-611. CrossrefGoogle Scholar36. SMITH CE: Coccidioidomycosis, Med. Clin. North Am., 1943, xxvii, 790-807. CrossrefGoogle Scholar37. SMITHBEARDWHITINGROSENBERGER CERREGHG: Varieties of coccidioidal infection in relation to the epidemiology and control of the diseases, Am. Jr. Pub. Health, 1946, xxxvi, 1394-1402. CrossrefGoogle Scholar38. SMITHWHITINGBAKERROSENBERGERBEARDSAITO CEEGEEHGRRMT: The use of coccidioidal, Am. Rev. Tuberc., 1948, lvii, 330-360. Google Scholar39. SWEIGERTTURNERGILLESPIE CFJWJB: Clinical and roentgenological aspects of coccidioidomycosis, Am. Jr. Med. Sci., 1946, ccxii, 652-673. CrossrefGoogle Scholar40. WILLETTWEISS FMA: Coccidioidomycosis in Southern California; Report of a new endemic area with a review of 100 cases, Ann. Int. Med., 1945, xxiii, 349-375. Google Scholar41. WINN WA: Coccidioidomycosis associated with pulmonary cavitation, Arch. Int. Med., 1941, lxviii, 1179-1214. CrossrefGoogle Scholar42. WINN WA: The treatment of pulmonary cavitation due to coccidioidal infection, Calif. and West. Med., 1942, lvii, 45-46. Google Scholar43. WIPER TB: Personal communication. Google Scholar44. YEGIANKEGEL DR: Coccidioides immitis infection of the lung; report of a case resembling chronic pulmonary tuberculosis, Am. Rev. Tuberc., 1940, xli, 393-397. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: San Francisco, California*Presented at the Twenty-Ninth Annual Session of the American College of Physicians, San Francisco, California, April 22, 1948.From the Commission on Acute Respiratory Diseases, Army Epidemiological Board, Office of the Surgeon General, Department of the Army, and its project for the study of coccidioidomycosis in the Department of Public Health and Preventive Medicine, Stanford University School of Medicine, San Francisco, California. Preliminary studies 1937-1941 were supported by the Rosenberg Foundation.The data presented are the result of coöperative effort. We cannot express adequately our gratitude even to the extent of listing all who provided histories and replied to our many inquiries. However, in the military hospitals we are especially indebted to Col. Hugh W. Mahon and his colleagues at Fitzsimons General Hospital. Among the civilians the following physicians provided especial aid: W. A. Winn, R. H. Smart, S. L. Goldman, M. A. Gifford and E. Bogen. Appreciation for notable specific collaboration of others is also indicated at the appropriate points of the text. 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