ELECTROLYTE METABOLISM AND ALDOSTERONE SECRETION IN BENIGN AND MALIGNANT HYPERTENSION
Authors: J H LARAGH, S ULICK, V JANUSZEWICZ, W G KELLY, S LIEBERMAN
Journal: Annals of Internal Medicine (1960)

Article1 August 1960ELECTROLYTE METABOLISM AND ALDOSTERONE SECRETION IN BENIGN AND MALIGNANT HYPERTENSIONJOHN H. LARAGH, STANLEY ULICK, VLODZIMIERZ JANUSZEWICZ, WILLIAM G. KELLY, SEYMOUR LIEBERMANJOHN H. LARAGH, STANLEY ULICK, VLODZIMIERZ JANUSZEWICZ, WILLIAM G. KELLY, SEYMOUR LIEBERMANAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-53-2-259 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe fundamental relationship between intravascular pressure and electrolyte metabolism is poorly understood. The hormones of the adrenal cortex which act to regulate sodium and potassium balance can produce hypertension both in man and in experimental animals.1, 2 The hypertensive state produced by adrenal mineralocorticoids such as desoxycorticosterone is dependent upon administration of adequate amounts of sodium in the diet, whereas the hypertension induced by glucocorticoids such as hydrocortisone differs in that it is less severe, and it is not dependent upon sodium intake.3Aldosterone, though more potent, produces effects on sodium and potassium metabolism similar to those of desoxycorticosterone. Aldosterone...Bibliography1. SelyeHallRowley HCEEM: Malignant hypertension produced by treatment with desoxycorticosterone acetate and sodium chloride, Canad. M. A. J. 49: 88, 1943. MedlineGoogle Scholar2. PereraKnowltonLowellLoeb GAAIARF: Effect of desoxycorticosterone acetate on the blood pressure of man, J. A. M. A. 125: 1030, 1954. CrossrefGoogle Scholar3. 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FerrebeeParkerCarnesGerityAtchleyLoeb JWDWHMKDWRF: Certain effects of desoxycorticosterone, the development of "diabetes insipidus" and the replacement of muscle potassium by sodium in normal dogs, Am. J. Physiol. 135: 230, 1941. CrossrefGoogle Scholar21. CookeSegarCheekColvilleDarrow REWEDBFEDC: The extrarenal correction of alkalosis associated with potassium deficiency, J. Clin. Investigation 31: 788, 1955. Google Scholar22. HildenKrogsgaard TAR: Low serum potassium level in severe hypertension, Am. J. M. Sc. 236: 487, 1958. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: New York, N. Y.*Received for publication April 29, 1960.Presented at the Forty-first Annual Session of The American College of Physicians, San Francisco, California, April 4, 1960.From the Departments of Medicine, of Obstetrics and Gynecology, and of Biochemistry, College of Physicians and Surgeons, Columbia University and The Presbyterian Hospital in the City of New York.†This work was supported by a grant from the U. S. Public Health Service (H-1275), the Fleitas Fund and by Mr. Daniel G. Arnstein.Requests for reprints should be addressed to John H. Laragh, M.D., Department of Medicine, Columbia University College of Physicians and Surgeons, Presbyterian Hospital, 620 West 168th Street, New York 32, N. Y. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited bySelecting Optimum Antihypertensive TherapyJohn H. 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ARMSTRONG, M.D., ANNETTE E. FITZ, M.D., LOUIS SCHWARTZ, M.D.Aldosterone AntagonistsProduction of potassium depletion by benzothiadiazine compounds∗On the Influence of Body Water Volume and Potassium Supply on the Aldosterone Excretion in Arterial Hypertension 1RENAL ISCHAEMIA AND HYPERTENSION : A REVIEW OF THE RESULTS OF SURGERYRelation of Aldosterone Secretion to Hypertensive Vascular DiseaseAldosteronism and Arterial Hypertension 1 August 1960Volume 53, Issue 2Page: 259-272KeywordsAldosteroneHospital medicineHypertensionIngestionMedical servicesMineralocorticoidsObstetrics and gynecologyPotassiumSodiumSurgeons ePublished: 1 December 2008 Issue Published: 1 August 1960 PDF downloadLoading ...