tbuckley/cabot-search huggingface dataset:
A Phase II Study of Modified Lenalidomide, Bortezomib, and Dexamethasone (RVD lite) for Transplant-Ineligible Patients with Newly Diagnosed Multiple Myeloma
Authors: Elizabeth O'Donnell, Jacob P. Laubach, Andrew J Yee, Carol Ann Huff, Frank Basile, Philip M. Wade, Claudia E. Paba-Prada, Irene M. Ghobrial, Robert L Schlossman, Nicole Couture, Lauren Doherty, Hannah Lyons, Caroline English, Nikhil Munshi, Kenneth C. Anderson, Paul G. Richardson, Noopur Raje
Journal: Blood (2014)
Response to: ‘Synovitis in knee osteoarthritis: a precursor or concomitant feature?’ by Zeng<i>et al</i>
Authors: Inoshi Atukorala, C Kent Kwoh, Ali Guermazi, Frank Roemer, Robert Boudreau, Michael J Hannon, David J Hunter
Journal: Annals of the Rheumatic Diseases (2015)

We thank Zeng et al 1 for their interest in our paper ‘Synovitis in knee osteoarthritis: a precursor of disease?’.2 We would like to clarify the reason we chose radiographs over MRI to identify early radiographic knee osteoarthritis (OA). We agree with the author's statement that MRI is more sensitive than knee radiographs for identification of early knee OA.3 However, at the moment the MRI definition of knee OA has not been …
The different nature of pulmonary vascular resistant and compliance in reduced and preserved ejection fraction heart failure and associated pulmonary hypertension
Authors: Yochai Adir, Laor Arie, Nabia Salman, Offer Amir
Journal: European Respiratory Journal (2014)

Background : Heart Failure (HF) is the most frequent cause of pulmonary hypertension (PH). The nature of the response of the pulmonary circulation to the increased left atrial pressure in patients with HF with reduced ejection fraction and pulmonary hypertension (HFrEF-PH) as opposed to patients with HF with preserved ejection fraction and pulmonary hypertension (HFpEF-PH) is unknown.   Methods : We investigate pulmonary hemodynamics profiles focusing mainly on pulmonary vascular compliance (PVC), by comparing the hemodynamic data from patients with HFrEF-PH to patients with HFpEF-PH.   Results : We retrospectively reviewed the clinical and hemodynamic data of 47 patients with HFrEF-PH and 37 with HFpEF-PH. Compare to patients with HFrEF-PH, patients with HFpEF-PH had significantly higher transpulmonary gradient (TPG) and the diastolic pulmonary gradient (DPG), with significantly higher PVR, while no significant difference was found in the PVC. PVR and PCWP had a significant impact on the PVC. However, in HFpEF-PH, PVR has the most impact on the PVC while the PCWP has a much minor effect whereas in HFrEF-PH the PCWP contribute more than the PVR.   Conclusion : Our results suggest that the association between PVR and PVC in patients with HF and associated PH has different characteristics when comparing reduced to preserved ejection fraction HF. Specifically, the contribution and the effect of PVR on the PVC is more prominent in the HFpEF-PH group while the impact of the wedge pressure was more significant in determining the PVC of the HFrEF-PH group.
Mammary Tumors, Hepatocellular Carcinomas, and Pancreatic Islet Changes in C3H-A vy Mice 2
Authors: Bernard Sass, Mina Lee Vernon, Robert L. Peters, Gary J. Kelloff
Journal: JNCI Journal of the National Cancer Institute (1978)

Studies of tumor incidence and assorted lesions found in 187 C3H-Avy mice throughout their natural life-spans revealed the following: Hepatocellular carcinomas occurred In 54.3% of males, mammary carcinomas in 95% of females, pancreatic islet cell adenomas In 9.4% of males and in no females, and pancreatic islet cell hyperplasia in 41% of males and 23% of females. Islet cell hyperplasia and adenomas appeared to consist predominantly of alpha and delta cells. Multiple tumors, or hyperplasia, or both, of a single site or of multiple sites occurred as frequently in males as they did in females–49.6% and 51.7%, respectively. The most frequent neoplasms were hepatocellular carcinomas and islet cell tumors or hyperplasia in males (45.7%) and multiple mammary tumors In females (30%). Heretofore unreported tumors found In this strain of mouse were 12 islet cell adenomas, 2 spindle cell tumors of the meninges and olfactory lobes, a squamous cell carcinoma of the nasal turbinates, and a schwannoma of the spermatic cord.
Electron Microscopic Observations on a “C”-Type Virus in Cell Cultures Derived From a Tumor-Bearing Viper&lt;xref ref-type="fn" rid="FN2"&gt;2&lt;/xref&gt;
Authors: R. F. Zeigel, H F. Clark
Journal: JNCI Journal of the National Cancer Institute (1969)

Electron microscopic studies on tissues and cell cultures derived from a tumor-bearing Russell's viper revealed a “C”-type, budding virus associated with the spleen cell line in late passage. Virions have not been observed in the primary tissues, the edematous myxofibroma, or other culture lines to date. The virions were approximately 108 mμ, membrane bound, and possessed a dense nucleoid. These observations support the extension of the range of this family of presumably RNA-containing viruses into the cold-blooded vertebrate group.
Genome-wide patterns and properties of de novo mutations in humans
Authors: Laurent C Francioli, Paz P Polak, Amnon Koren, Androniki Menelaou, Sung Chun, Ivo Renkens, Cornelia M van Duijn, Morris Swertz, Cisca Wijmenga, Gertjan van Ommen, P Eline Slagboom, Dorret I Boomsma, Kai Ye, Victor Guryev, Peter F Arndt, Wigard P Kloosterman, Paul I W de Bakker, Shamil R Sunyaev
Journal: Nature Genetics (2015)
Natural Antibodies Directed Against Murine Lymphosarcoma Cells 2
Authors: Marco A. Pierotti, Maria I. Colnaghi
Journal: JNCI Journal of the National Cancer Institute (1975)

Natural antibodies reacting in a test of complement-dependent cytotoxicity with untreated murine lymphosarcoma cells of thymic origin were found in murine sera. Normal thymus cells were unaffected and unable to absorb the serum activity. The natural antibodies were IgM-like and stable at 56 degrees C. They were not uniformly distributed in the studied strains, and high (C3H/He and C3Hf), intermediate (AKR and CBA/J), and low level strains (BALB/c, DBA/2, C57BL, and C57BL/6J) were found. Hybrids between a high (C3Hf) and a low level strain (C57BL) had the same response as the parental C3Hf mice. An inverse relationship was demonstrated between cytotoxicity of, and susceptibility to, serum of lymphoma cells in a given strain, which suggested that an immunologic modulation was at work. Embryonic cells absorbed the cytotoxic activity of the normal serum.
Treatment of advanced Hodgkin's disease with chemotherapy--comparison of MOPP/ABV hybrid regimen with alternating courses of MOPP and ABVD: a report from the National Cancer Institute of Canada clinical trials group.
Authors: J M Connors, P Klimo, G Adams, B F Burns, I Cooper, R M Meyer, S E O'Reilly, J Pater, I Quirt, A Sadura, C Shustik, J Skillings, S Sutcliffe, S Verma, S Yoshida, B Zee
Journal: Journal of Clinical Oncology (1997)

PURPOSE This randomized, prospective trial compares outcomes for patients with advanced Hodgkin's disease treated with mechlorethamine, vincristine, procarbazine, and prednisone (MOPP)/doxorubicin, bleomycin, and vinblastine (ABV) hybrid regimen or alternating MOPP/doxorubicin, bleomycin, vinblastine, and dacarbazine (ABVD). METHODS Three hundred one patients with advanced Hodgkin's disease were randomized to receive MOPP/ ABV hybrid regimen or alternating MOPP/ABVD after stratification for prior treatment, B symptoms, and treatment center. Eligible patients were either previously untreated and found to have stage IIIB, IVA, or IVB disease or previously treated with wide-field irradiation. Responding patients received a minimum of eight cycles of chemotherapy. Those with residual disease in a localized region received irradiation between the sixth and seventh cycle of treatment. RESULTS Response rates to the two regimens were similar. Five-year overall survival rates were 81% and 83% for MOPP/ABV hybrid and alternating MOPP/ ABVD, respectively (P = .74; 95% confidence interval [CI] for the difference, -11% to 7%). Five-year failure-free survivals were 71% and 67% for MOPP/ABV hybrid and alternating MOPP/ABVD, respectively (P = .87; 95% CI for the difference, -9% to 17%). Significantly more episodes of febrile neutropenia and stomatitis were observed with the MOPP/ABV hybrid regimen; there was no significant difference in fatal toxicity. Patients with predefined, high-quality partial responses (PR-1s) had results similar to those with complete responses (CRs). Planned subset analysis showed no significant difference in outcome between the two arms of the trial for patients with newly diagnosed disease (5-year failure-free survival rates were 70% for MOPP/ABV hybrid and 59% for alternating MOPP/ABVD; P = .180), but superiority of alternating MOPP/ABVD for patients with prior irradiation (5-year failure-free survival 94% v 73%; P = .017). CONCLUSION MOPP/ABV hybrid and alternating MOPP/ABVD regimens are equally effective for patients with advanced Hodgkin's disease.
CEA and CA19-9 measurement as a monitoring parameter in metastatic colorectal cancer (CRC) under palliative first-line chemotherapy with weekly 24-hour infusion of high-dose 5-fluorouracil (5-FU) and folinic acid (FA)
Authors: B. Hanke, C. Riedel, S. Lampert, K. Happich, P. Martus, H. Parsch, B. Himmler, W. Hohenberger, E.G. Hahn, A. Wein
Journal: Annals of Oncology (2001)
Modulation of extracellular matrix in cancer is associated with enhanced tumor cell targeting by bacteriophage vectors
Authors: Teerapong Yata, Eugene L. Q. Lee, Keittisak Suwan, Nelofer Syed, Paladd Asavarut, Amin Hajitou
Journal: Molecular Cancer (2015)

Gene therapy has been an attractive paradigm for cancer treatment. However, cancer gene therapy has been challenged by the inherent limitation of vectors that are able to deliver therapeutic genes to tumors specifically and efficiently following systemic administration. Bacteriophage (phage) are viruses that have shown promise for targeted systemic gene delivery. Yet, they are considered poor vectors for gene transfer. Recently, we generated a tumor-targeted phage named adeno-associated virus/phage (AAVP), which is a filamentous phage particle whose genome contains the adeno-associated virus genome. Its effectiveness in delivering therapeutic genes to tumors specifically both in vitro and in vivo has been shown in numerous studies. Despite being a clinically useful vector, a multitude of barriers impede gene transduction to tumor cells. We hypothesized that one such factor is the tumor extracellular matrix (ECM).We used a number of tumor cell lines from different species and histological types in 2D monolayers or 3D multicellular tumor spheroid (MCTS) models. To assess whether the ECM is a barrier to tumor cell targeting by AAVP, we depleted the ECM using collagenase, hyaluronidase, or combination of both. We employed multiple techniques to investigate and quantify the effect of ECM depletion on ECM composition (including collagen type I, hyaluronic acid, fibronectin and laminin), and how AAVP adsorption, internalisation, gene expression and therapeutic efficacy are subsequently affected. Data were analyzed using a student's t test when comparing two groups or one-way ANOVA and post hoc Tukey tests when using more than two groups.We demonstrate that collagenase and hyaluronidase-mediated degradation of tumor ECM affects the composition of collagen, hyaluronic acid and fibronectin. Consequently, AAVP diffusion, internalisation, gene expression and tumor cell killing were enhanced after enzymatic treatment. Our data suggest that enhancement of gene transfer by the AAVP is solely attributed to ECM depletion. We provide substantial evidence that ECM modulation is relevant in clinically applicable settings by using 3D MCTS, which simulates in vivo environments more accurately.Our findings suggest that ECM depletion is an effective strategy to enhance the efficiency of viral vector-guided gene therapy.
Genetic differences in COPD secondary to wood smoke and tobacco smoking
Authors: Gloria Pérez-Rubio, Ramcés Falfán-Valencia, Alejandra Ramírez-Venegas, Juan Carlos Fernández-López, Angel Camarena, María Inés Vargas, Raúl Sansores
Journal: European Respiratory Journal (2013)

Background: COPD is a complex disease with different respiratory symptoms and lung damage, smoking is the main risk factor, however, exposure to smoke from burning biomass (wood smoke) is involved in the establishment of the disease, particularly in developing countries, the objective of this study is to assess whether there are genetic differences in susceptibility to COPD in relation to the risk factor in Mexican mestizo population.  Methods: We included 83 patients with COPD secondary to wood smoke (WS) exposure and 198 secondary to tobacco smoking (TS). It was designed a microarray (Illumina, CA, USA) with 1536 single nucleotide polymorphisms (SNPs), 1285 related to the disease or a phenotype associated and 251 ancestry informative markers. Were employed the analysis software SPSS, STRUCTURE, PLINK and Haploview.  Results: 4 SNPs in  IL10 , and  EPHX1 ,  SERPINE2  were significantly associated to COPD secondary WS exposure.  19 haplotypes were associated in 6 genes:  IL6 ,  CYP2B6 ,  SFTPD ,  SERPINE1 ,  ADAM19  and  SERPINE2 .  Conclusions: There are genetic differences in COPD when compared TS to WS that may contribute to different forms of injury or severity in the lungs.
The effect of a mechanical insufflator-exsufflator on wall shear stress by functional respiratory imaging
Authors: Glenn Leemans, Kris Ides, Tanja Van Doninck, Cedric Van Holsbeke, Jan De Backer, Wim Vos, Wilfried De Backer
Journal: European Respiratory Journal (2014)

Rationale   The linear velocity of gas flow of a mechanical insufflator-exsufflator (MI-E) is of importance in applying sufficient wall shear stress to clear mucus. This study tries to determine the effect inspiratory and expiratory velocity of a MI-E (Cough Assist E70, Phillips Respironics) on wall shear stress in central airways in two clinical conditions: tracheostomy and facemask.   Methods   Functional respiratory imaging is used to create a patient-specific model of the airways and to simulate airflow. Inspiratory flow setting: average flow of 5.2L/s with three rise time profiles as comfort function: slow, medium and fast. Expiratory flow setting: average flow of 4.23L/s as minimum.   Results   Flow simulation with mask reveals that wall shear stress of the inspiratory flow was less or equal to the expiratory flow during all rise time profiles. For tracheostomy, this only occurs with a slow rise time, while wall shear stress of the inspiratory flow with medium and fast rise time exceeds those of the expiratory flow.   Conclusion   When wall shear stress of inspiratory flow exceeds those of the expiratory flow, mucus in central airways can be transported to peripheral airways which make the simulated cough with a MI-E less efficient. Therefore, a slow rise time as comfort function in MI-E should theoretically be favored in tracheostomized patients.
Abstract 1588: Adipokine Resistin Induces Expression of Adhesion Molecules and Tissue Factor in Human Coronary Artery Endothelial Cells
Authors: Paolo Calabro, Plinio Cirillo, Valeria Maddaloni, Giuseppe Limongelli, Sara Weisz, Maria Antonietta Rucco, Rosalinda Palmieri, Lucia Riegler, Raffaele De Palma, Massimo Chiariello, Paolo Golino, Raffaele Calabro
Journal: Circulation (2006)

Objective: Atherosclerosis is characterized by endothelial inflammation and dysfunction. Adipose tissue has been increasingly recognized as an active endocrine organ secreting so-called adipokines,...
Ventilation inhomogeneity in preterm children at school age
Authors: Sophie Yammine, Florian Singer, Anne Schmidt, Oliver Sutter, Urs Frey, Philipp Latzin
Journal: European Respiratory Journal (2013)

Background  Preterm birth with or without subsequent chronic lung disease was shown to be associated with increased ventilation inhomogeneity (VI) in the neonatal period, but little is known at later age.   Objective  To assess VI in formerly preterm born children at school age.   Methods  34 preterm and 27 term-born children performed triplicate nitrogen multiple-breath washout (MBW), nitrogen single-breath washout (SBW) and helium-sulfurhexafluoride mixture SBW at school age. We compared the lung clearance index (LCI), Scond and Sacin from MBW and the slope of phase III (SIII) from SBW. Z-scores were derived from the term-born controls.   Results  Mean age of the preterm children was 10.1 (range 8.0 to 12.8) years, mean gestational age at birth was 28.6 (24.9 to 34.7) weeks. VI measured by the following parameters was significantly increased in preterms: Scond with mean difference of 1.27 (0.58 - 1.96) z-scores, SIII from nitrogen SBW with mean difference of 0.96 (0.12 - 1.79) z-scores and SIII from the gas mixture SBW with mean difference of 1.96 (0.92 - 3.00) z-scores. Neither LCI nor Sacin differed significantly between preterm and term-born children, mean differences (95% CI) were 0.37 (-0.31 - 1.05) and 0.48 (-0.24 - 1.20) z-scores.   Conclusion  Former preterms show increased VI compared to term born children at school age. Regional VI in the lung periphery seems to be more affected than global VI measured by LCI. Varying differences of measured parameters between preterm and term-born children suggest a complex pattern of disturbed lung development in different regions of the airways.
Human Blood Group Isoantigen Expression on Normal and Malignant Gastric Epithelium Studied With Anti-A and Anti-B Monoclonal Antibodies&lt;xref ref-type="fn" rid="fn2"&gt;2&lt;/xref&gt;
Authors: P J Finan, D G Wight, E S Lennox, S H Sacks, N M Bleehen
Journal: JNCI Journal of the National Cancer Institute (1983)

Variation in human blood group isoantigen expression on normal and malignant gastric epithelium was demonstrated with monoclonal antibodies to blood groups A and B in an indirect immunoperoxidase technique. The expected isoantigen expression was demonstrated on endoscopic biopsy specimens of normal gastric mucosa from 11 patients. Of 17 patients with gastric carcinoma (blood group A, 15; blood group AB, 2), complete loss of isoantigen expression was noted in 6 (35%). In these 6 patients, blood group isoantigen remained both in the adjacent uninvolved mucosa and at the margin of resection. The loss of isoantigen did not appear to be related to the degree of differentiation within the tumor, to the secretor status of the patient, or to the blood subgroup. Lymph node metastases reflected the isoantigen status of the primary tumor, being positive in 5 of 6 expression in all 17 patients or in an additional 15 patients studied with blood group O. These findings were discussed in the light of previously reported work on the localization of blood group isoantigens on malignant and nonmalignant gastric epithelium with the use of conventional antisera and a variety of immunohistologic techniques.
Decreasing candidaemia rate in abdominal surgery patients after introduction of fluconazole prophylaxis*
Authors: B.J. Holzknecht, J. Thorup, M.C. Arendrup, S.E. Andersen, M. Steensen, P. Hesselfeldt, J.M. Nielsen, J.D. Knudsen
Journal: Clinical Microbiology and Infection (2010)
In Vitro Assay of the Effects of Psoralens Plus Ultraviolet Radiation on Human Lymphoid Cells&lt;xref ref-type="fn" rid="FN1"&gt;1&lt;/xref&gt;
Authors: Kenneth H. Kraemer
Journal: JNCI Journal of the National Cancer Institute (1982)

An in vitro assay system that mimics some of the features of in vivo oral methoxsalen photochemotherapy (PUVA) in relation to human lymphoid cells was developed. In this assay, suspension cultures of human lymphoid cells were subjected to therapeutic concentrations of 8-MOP and to a UVA radiation spectrum modified to approximate the dermal exposure. The assay permitted correlation and quantitation of multiple 8-MOP plus UVA-induced biological and physical alterations in the same assay system. Thus were demonstrated inhibition of DNA synthesis, reduction of cell survival, production of DNA cross-links, and loss of mixed leukocyte reactivity induced by combinations of 8-MOP and UVA in or near the presumed therapeutic range. This assay may be useful for predicting lymphoid cellular toxicity of other photoactive agents as well as for examining the molecular effects of these agents.
Focusing on the Flood
Authors: Joe G. N. Garcia
Journal: American Journal of Respiratory and Critical Care Medicine (2011)

23,24), thus allowing vitamin D deficiency to affect the developing lung and the subsequent risk of asthma via multiple mechanisms.The public health importance of the hypothesis that vitamin D is critically related to asthma is fueled by the knowledge that currently over 90% of African-American pregnant women and over 60% of white pregnant women are vitamin D-deficient or -insufficient (25,26).This is not true of other major hormonal moderators of lung development such as vitamin A. Clinical trials of vitamin D to prevent asthma are currently underway in both the United States (Vitamin D Antenatal Asthma Reduction Trial [VDAART], U01 HL091528) and in Denmark (ClinicalTrials.gov: NCT00856947).These studies will test only part of vitamin D's influence on asthma risk, namely the fetal origins effect.What will not be tested in these trials is the relative importance of postnatal vitamin D sufficiency versus in utero sufficiency in asthma prevention.It is quite likely that both pre-and postnatal sufficiency will be required to maximally lower risk.There are still many studies that need to be performed on vitamin D and its protean health effects-for example, its effect on pre-eclamsia, preterm birth generally, and hence on Respiratory Distress Syndrome of the newborn and subsequent bronchopulmonary dysplasia.These initial trials should at least begin to provide the clinical basis for determining whether there is a role of vitamin D as a preventative for asthma, but there is much more work to be done.
Staging Presymptomatic Type 1 Diabetes: A Scientific Statement of JDRF, the Endocrine Society, and the American Diabetes Association
Authors: Richard A. Insel, Jessica L. Dunne, Mark A. Atkinson, Jane L. Chiang, Dana Dabelea, Peter A. Gottlieb, Carla J. Greenbaum, Kevan C. Herold, Jeffrey P. Krischer, Åke Lernmark, Robert E. Ratner, Marian J. Rewers, Desmond A. Schatz, Jay S. Skyler, Jay M. Sosenko, Anette-G. Ziegler
Journal: Diabetes Care (2015)

Insights from prospective, longitudinal studies of individuals at risk for developing type 1 diabetes have demonstrated that the disease is a continuum that progresses sequentially at variable but predictable rates through distinct identifiable stages prior to the onset of symptoms. Stage 1 is defined as the presence of β-cell autoimmunity as evidenced by the presence of two or more islet autoantibodies with normoglycemia and is presymptomatic, stage 2 as the presence of β-cell autoimmunity with dysglycemia and is presymptomatic, and stage 3 as onset of symptomatic disease. Adoption of this staging classification provides a standardized taxonomy for type 1 diabetes and will aid the development of therapies and the design of clinical trials to prevent symptomatic disease, promote precision medicine, and provide a framework for an optimized benefit/risk ratio that will impact regulatory approval, reimbursement, and adoption of interventions in the early stages of type 1 diabetes to prevent symptomatic disease.