tbuckley/cabot-search huggingface dataset:
Abstract 14368: Long Term Freedom From Atrial Fibrillation In Patients With Paroxysmal Atrial Fibrillation and Documented Pulmonary Vein Antrum Isolation.
Authors: Luigi Di Biase, Antonio Dello Russo, Michela Casella, Pasquale Santangeli, Rong Bai, Prasant Mohanty, J. David Burkhardt, Javier E. Sanchez, Rodney Horton, Raimondo Massaro, Domenico Potenza, Gemma Pelargonio, Giovanni Forleo, Sakis Themistoklakis, Antonio Raviele, Sanghamitra Mohanty, Claudio Tondo, Andrea Natale
Journal: Circulation (2011)

Introduction:  Long term freedom from atrial fibrillation (AF), in patients with paroxysmal AF (PAF) and proven isolation of the pulmonary vein is unknown.   Methods:  Ninety eight (98) consecutive patients with PAF undergoing ablation were enrolled in this study. Patients underwent pulmonary vein antrum (PVA) isolation. In the period between 3 to 6 months post ablation, irrespective of recurrences, patients underwent a left atrial catheterization to exclude the presence of pulmonary vein reconnection. In case of reconnection, patients underwent re-isolation of the pulmonary veins and a third procedure was considered to confirm permanent isolation. Patients were followed-up after the last procedure showing isolation with event recordings and 7-day Holters. After documented PVA isolation, and in case of recurrence, an additional procedure was considered during which non-PV triggers were identified with the administration of high dose of isoproterenol.   Results:  After a single procedure PVA remained isolated in 58% of the cases (57pts). The 41 patients (42%) with PV reconnection underwent re-isolation of the PVA. At the third procedure all PVs, except in 1 patient, remained isolated. At 46±6 months of follow-up the overall success rate was 74% off AADs. The success rate was 91 % at 6 months follow up, 87% at 1 year, 79% at two years, 76% at 3 years, and 74% at the last follow up. At the multivariate analysis, long episode of AF (more than 24 hours) [hazard ratio (HR) 1.70, 95% CI 1.34 to 2.16, p=0.002], left atrial size (>4.5cm) (HR 1.96, 95% CI 1.11 to 3.46, p= 0.02) and female sex (HR 3.26, 95% CI 1.05 to 5.26, p=0.04) were predictors of long term failure despite PVA isolation. Figure   Conclusions:  In patients with PAF, permanent PVA isolation alone is associated with a good long term freedom from AF. Recurrence due to non PV triggers appeared clustered in the first 2 years. Whether non PVA triggers become relevant later in the patient life is unclear.
Prostaglandin E1 enhances the histamine induced stimulation of the mucociliary activity in the rabbit maxillary sinus
Authors: J Dolata
Journal: European Respiratory Journal (1990)

Inflammatory mediators are released in the airways during both inflammatory and allergic reactions, and many of these mediators affect mucociliary activity. To discover whether mucociliary activity is changed by a combination of mediators, the interaction between prostaglandins and histamine or methacholine was studied in vivo in the rabbit maxillary sinus. We used a photoelectric technique and recorded frequency changes induced by tested substances. Prostaglandins E1 and F2 alpha (PGE1 and PGF2 alpha) were given as ia. infusions followed by bolus injections of histamine or methacholine. Infusion with PGE1 (0.1 microgram.kg-1) enhanced the stimulating effect of a subsequent injection of histamine (10 micrograms.kg-1), maximum stimulation being 33 +/- 6% compared to 14 +/- 4% after histamine alone (p = 0.02). When the histamine injection was given 20 min after PGE1 no enhancement was observed. PGE1 did not enhance the stimulating effect of methacholine. In contrast to PGE1, PGF2 alpha failed to enhance the effect of histamine. It is proposed that a role of PGE1 is to modify the mucociliary response to other mediators released during inflammatory and allergic reactions.
Prospective Randomized Trial of Docetaxel Versus Mitomycin Plus Vinblastine in Patients With Metastatic Breast Cancer Progressing Despite Previous Anthracycline-Containing Chemotherapy
Authors: J.-M. Nabholtz, H. J. Senn, W. R. Bezwoda, D. Melnychuk, L. Deschênes, J. Douma, T. A. Vandenberg, B. Rapoport, R. Rosso, V. Trillet-Lenoir, J. Drbal, A. Molino, J.W.R. Nortier, D. J. Richel, T. Nagykalnai, P. Siedlecki, N. Wilking, J. Y. Genot, P.S.G.J. Hupperets, F. Pannuti, D. Skarlos, E. M. Tomiak, M. Murawsky, M. Alakl, A. Riva, M. Aapro
Journal: Journal of Clinical Oncology (1999)

PURPOSE: This phase III study compared docetaxel with mitomycin plus vinblastine (MV) in patients with metastatic breast cancer (MBC) progressing despite previous anthracycline-containing chemotherapy. PATIENTS AND METHODS: Patients (n = 392) were randomized to receive either docetaxel 100 mg/m 2 intravenously (IV) every 3 weeks (n = 203) or mitomycin 12 mg/m 2 IV every 6 weeks plus vinblastine 6 mg/m 2 IV every 3 weeks (n = 189), for a maximum of 10 3-week cycles. RESULTS: In an intention-to-treat analysis, docetaxel produced significantly higher response rates than MV overall (30.0% v 11.6%; P &lt; .0001), as well as in patients with visceral involvement (30% v 11%), liver metastases (33% v 7%), or resistance to previous anthracycline agents (30% v 7%). Median time to progression (TTP) and overall survival were significantly longer with docetaxel than MV (19 v 11 weeks, P = .001, and 11.4 v 8.7 months, P = .0097, respectively). Neutropenia grade 3/4 was more frequent with docetaxel (93.1% v 62.5%; P &lt; .05); thrombocytopenia grade 3/4 was more frequent with MV (12.0% v 4.1%; P &lt; .05). Severe acute or chronic nonhematologic adverse events were infrequent in both groups. Withdrawal rates because of adverse events (MV, 10.1%; docetaxel, 13.8%) or toxic death (MV, 1.6%; docetaxel, 2.0%) were similar in both groups. Quality-of-life analysis was limited by a number of factors, but results were similar in both groups. CONCLUSION: Docetaxel is significantly superior to MV in terms of response, TTP, and survival. The safety profiles of both therapies are manageable and tolerable. Docetaxel represents a clear treatment option for patients with MBC progressing despite previous anthracycline-containing chemotherapy.
THE ROLE OF THE EPIDERMIS IN THE HISTOPATHOGENESIS OF LICHEN AMYLOIDOSUS.
Authors: MARTIN M. BLACK
Journal: British Journal of Dermatology (1971)

Journal Article THE ROLE OF THE EPIDERMIS IN THE HISTOPATHOGENESIS OF LICHEN AMYLOIDOSUS: HISTOCHEMICAL CORRELATIONS Get access MARTIN M. BLACK MARTIN M. BLACK The Department of Histopathology, The Institute of Dertnatuiogy, St John's Hospital, London, W.C.2 Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 85, Issue 6, 1 December 1971, Pages 524–530, https://doi.org/10.1111/j.1365-2133.1971.tb14077.x Published: 01 December 1971 Article history Accepted: 28 June 1971 Published: 01 December 1971
Dyspnoea in COPD patients recorded in a primary care database
Authors: Hana Mullerova, Chao Lu, Maggie Tabberer
Journal: European Respiratory Journal (2011)

Background:  Dyspnoea is a primary clinical feature of COPD [1,2]. Information on dyspnoea recording in electronic medical record databases has not yet been reported.   Methods:  A cohort was identified in the UK General Practice Research Database (GPRD) (01/01/2003 – 30/6/2010) with both a COPD medical diagnosis code and spirometry (FEV1/FVC    Results:  A cohort of 9502 patients was identified: mean age 67 y. (SD 11), 55% males, GOLD stage I: 12%, II: 50%, III: 29%, and IV: 7%. At least one “probable” dyspnoea code was found in 76% of COPD patients; “possible” codes were identified in 2% of patients. Codes most frequently associated with dyspnoea were “shortness of breath” (16% of patients) and MRC Dyspnoea Scale grade; 45% patients recorded as grade 2, 34% grade 3 and 5.5% grade 4 (frequencies based on the total cohort). Dyspnoea was more often reported by older patients and those with more advanced disease (69% patients in GOLD stage I with “probable” dyspnoea vs. 81% in GOLD stages II or IV).   Conclusions:  Dyspnoea was reported in > 75% of COPD patients identified in the GPRD. The high frequency of dyspnoea across all GOLD stages highlights this symptom as a significant burden and possible unmet need in COPD treatment. MRC Dyspnoea grade is the predominant code used, linked to the Quality Outcomes Framework, an NHS system supporting management of selected diseases.   References:   1Bestall JC, Paul EA, Garrod R et al. Thorax 1999;54:581–6.  2GOLD: Pocket Guide, December 2010.  Funded by GSK.
Comparison of nebulized and sprayed topical anaesthesia for fibreoptic bronchoscopy
Authors: D Keane, WT McNicholas
Journal: European Respiratory Journal (1992)

We compared the efficacy of nebulized (N) and sprayed (S) topical anaesthesia prior to fibreoptic bronchoscopy in a blinded study involving 54 patients aged 57 +/- 26 yrs (mean +/- SD). Cough frequency, recorded on cassette tape, was the index of efficacy. All patients received 100 mg lignocaine sprayed into the pharynx, or nebulized in random order prior to bronchoscopy, and all received intravenous diazepam sedation. Each patient received a further 100 mg of lignocaine solution through the bronchoscope onto the vocal cords and major airways during the procedure. No significant difference was found in overall cough frequency between N and S groups (8.7 +/- 6.9 coughs.min-1 N vs 10.5 +/- 6.0 S), and cough frequency was also similar between N and S during the periods above and below the vocal cords. Furthermore, no differences were found in cough frequency between N and S among smokers, patients with asthma and COPD, and patients who had a biopsy procedure, although a trend was seen in all comparisons towards a lower cough frequency with the nebulized route. Most patients in the S group found the spray unpleasant, whereas only one in the N group complained. We conclude that nebulized and sprayed lignocaine have similar efficacy as topical anaesthetics in fibreoptic bronchoscopy, but patient preference favours the nebulized route.
Reducing accident death rates in children and young adults: the contribution of hospital care
Authors: I. Roberts, F. Campbell, S. Hollis, D. Yates
Journal: BMJ (1996)

<h3>Abstract</h3> <b>Objective</b>: To assess the contribution of trauma care to the recent decline in accident death rates among children and young people. <b>Design</b>: Logistic regression modelling of temporal trends in the probability of death in patients admitted to hospital for the treatment of severe injury. <b>Setting</b>: Hospitals participating the United Kingdom major trauma outcome study. <b>Subjects</b>: 3230 patients with an injury severity score of 16 or more, who were admitted for more than three days, transferred or admitted to intensive care, or died from their injuries. <b>Main outcome measures</b>: Death or survival in hospital within three months of injury. <b>Results</b>: Over the seven year period 1989–95 there was a substantial decline in the probability of death among children and young adults admitted to hospital after severe injury. The overall estimate of the reduction in the odds of death was 16% per year (odds ratio for the yearly trend 0.84; 95% confidence interval 0.79 to 0.89). This decline did not differ significantly between age groups. (0–4 years 0.79; 5–14 years 0.87; 15–24 years 0.83). <b>Conclusions</b>: Reductions in hospital case fatality have made an important contribution to reaching the Health of the Nation targets. The contribution of hospital care in the reduction of accident mortality should be taken into account in decisions about the allocation of resources to preventive and curative services. <h3>Key messages</h3> Government publications emphasise the role of accident prevention in reaching the targets, but the hospital care of seriously injured children might also make an important contribution Analyses of data from the major trauma outcome study show that, after severity of injury is control- led for, there has been a substantial decline in hos- pital case fatality for severe injury Over the seven year period 1989–95 the odds of death after severe injury declined by 16% a year The contribution of hospital care to the reduction of child accident mortality should be taken into account in decisions about the allocation of resources to preventive and curative services
Early in-situ cellularization of a supramolecular vascular graft is modified by synthetic stromal cell-derived factor-1α derived peptides
Authors: Dimitri E.P. Muylaert, Geert C. van Almen, Hanna Talacua, Joost O. Fledderus, Jolanda Kluin, Simone I.S. Hendrikse, Joost L.J. van Dongen, Eline Sijbesma, Anton W. Bosman, Tristan Mes, Shraddha H. Thakkar, Anthal I.P.M. Smits, Carlijn V.C. Bouten, Patricia Y.W. Dankers, Marianne C. Verhaar
Journal: Biomaterials (2015)
Inhibition of NKCC1 may be beneficial in sepsis
Authors: B Jayaraman
Journal: Thorax (2008)

Mortality related to bacteraemic pneumonia remains high, and previous studies have shown that the Na+–K+–Cl cotransporter (NKCC1) may have an important role in causing acute lung injury secondary to compromise of the alveolar-capillary barrier. Under normal physiological conditions, NKCC1 plays a central role in salt transport and volume …
Effect of tiotropium bromide on collagen-IV level: Results from 180-days study in subjects with moderate COPD
Authors: Mykola Ostrovskyy, Mariana Kulynych-Miskiv, Iryna Savelikhina, Oleksandr Varunkiv
Journal: European Respiratory Journal (2014)

OBJECTIVE:  We investigated the effects of treatment with the long-acting muscarinicreceptor antagonist tiotropium on collagen-IV level in bronchoalveolar fluid before and during the treatment in patient with COPD II stages.   METHODS: The type IV collagen was tested using commercially available ELISA kits, in accordance with the manufacturer9s recommendations (Collagen IV ELISA®, Echelon Biosciences Inc, Salt Lake City, EUA).  The content of type IV collagen was investigated in bronchoalveolar fluid after bronchoscopy in 49 patients with stage 2 COPD before and after treatment. The severity of COPD was classified by the FEV1 % predicted, according to the guidelines established by the GOLD.  RESULTS: The results of our research showed that in patients with COPD on early stages (2nd stage) was accompanied by increased content of collagen type IV in bronchoalveolar fluid in 6.19 times compared with healthy. We found further positive trends - reduction of type IV collagen on 79.4% with using tiotropium bromide within 2 months. The level of type IV collagen in bronchoalveolar fluid dropped in 2.23 times (p  Finally, we identified practically complete normalization of type IV collagen levels in bronchoalveolar fluid only during 6-month of tiotropium bromide admission in patients with stage 2 COPD. This rate was higher only at 29.8% (p    CONCLUSIONS:  The reduction of type IV collagen content in bronchoalveolar fluid under tiotropium bromide treatment during 6 month is a clear evidence of inhibiting effects of tiotropium bromide on the processes of neocollagenesis.
RNA Toxicity from the ALS/FTD C9ORF72 Expansion Is Mitigated by Antisense Intervention
Authors: Christopher J. Donnelly, Ping-Wu Zhang, Jacqueline T. Pham, Aaron R. Haeusler, Nipun A. Mistry, Svetlana Vidensky, Elizabeth L. Daley, Erin M. Poth, Benjamin Hoover, Daniel M. Fines, Nicholas Maragakis, Pentti J. Tienari, Leonard Petrucelli, Bryan J. Traynor, Jiou Wang, Frank Rigo, C. Frank Bennett, Seth Blackshaw, Rita Sattler, Jeffrey D. Rothstein
Journal: Neuron (2013)
Abstract 15730: Serum Interferon Alpha 21 is a Biomarker of the 9p21.3 Risk Locus for Coronary Artery Disease
Authors: Naif A Almontashiri, Meng Fan, Hsiao-Huei Chen, Allen C Teng, Brian L Chen, Ruth McPherson, Robert Roberts, Alexandre F Stewart
Journal: Circulation (2011)

Background - The 9p21.3 locus confers risk for coronary artery disease (CAD) by an unknown mechanism. A recent report identified several long-range enhancers, at CDKN2B, CDKN2A, MTAP and between th...
Mutations in the fibrinogen Aα gene account for the majority of cases of congenital afibrinogenemia
Authors: Marguerite Neerman-Arbez, Philippe de Moerloose, Claire Bridel, Ariane Honsberger, Anni Schönbörner, Colette Rossier, Kathelijne Peerlinck, Ségolène Claeyssens, Donna Di Michele, Roseline d'Oiron, Marie Dreyfus, Monique Laubriat-Bianchin, Jacelyne Dieval, Stylianos E. Antonarakis, Michael A. Morris
Journal: Blood (2000)
Association Between Total Hip Replacement Characteristics and 3-Year Prosthetic Survivorship
Authors: Sandrine Colas, Cédric Collin, Philippe Piriou, Mahmoud Zureik
Journal: JAMA Surgery (2015)

Total hip replacement (THR) is successful in treating hip arthritis. Prosthetic survivorship may depend on characteristics of the implant, notably THR fixation technique and bearing surface type.To compare THR short-term survivorship according to cement type and bearing surface.The cohort included all French patients aged 40 years or older covered by the general scheme of the French national health insurance system who had undergone THR from April 1, 2010, through December 31, 2011, for arthritis, according to French national health insurance databases. The cohort was followed up until December 31, 2013. The THR survivorship was assessed according to cement type and bearing surface in univariate and multivariate Cox proportional hazards regression models adjusted for patient and implanting center characteristics.Antibiotic-free cemented THRs and antibiotic-impregnated cemented THRs were compared with uncemented THRs. Ceramic-on-ceramic (CoC), ceramic-on-polyethylene (CoP), and metal-on-metal (MoM) THRs were compared with metal-on-polyethylene (MoP) THRs.Revision, including any surgical reintervention in which the implant or any of its components was changed or removed.The study cohort comprised 100 191 individuals: mean age at baseline, 69.5 years; women, 56.6%; uncemented THR, 74.8%; antibiotic-free cemented THR, 3.8%; antibiotic-impregnated cemented THR, 21.4%; CoC, 40.9%; MoP, 33.9%; CoP, 20.8%; and MoM, 4.4%. During the median 33-month follow-up period, 3142 individuals underwent prosthetic revision. Antibiotic-impregnated cemented THRs had a better prognosis than uncemented THRs: cumulative revision rates were 2.4% and 3.3%, respectively (P < .001), and the multivariate adjusted hazard ratio was 0.75 (95% CI, 0.67-0.84; P < .001). This association was particularly significant in women. The CoP and CoC THRs were no different from the MoP THR. The MoM THR had slightly shorter survivorship compared with the MoP THR (adjusted hazard ratio, 1.20; 95% CI, 1.01-1.43; P < .001).Characteristics of THR are related to early prosthetic revision: antibiotic-impregnated cemented THRs have a better prognosis and MoM THRs a worse one. These findings are useful in helping surgeons select a THR fixation technique and helpful for both patient and surgeon in the decision-making process.
Karyotype and Tumorigenicity of 1-Methylguanine-Transformed Chinese Hamster Cells2
Authors: R. W. Trewyn, Sylvia J. Kerr, John M. Lehman
Journal: JNCI Journal of the National Cancer Institute (1979)

Journal Article Karyotype and Tumorigenicity of 1-Methylguanine-Transformed Chinese Hamster Cells Get access R. W. Trewyn, R. W. Trewyn 3Department of Biochemistry, University of Colorado Medical Center, Denver, Colo. 80262. Search for other works by this author on: Oxford Academic PubMed Google Scholar Sylvia J. Kerr, Sylvia J. Kerr 4 3Department of Biochemistry, University of Colorado Medical Center, Denver, Colo. 80262. 4Address reprint requests to Dr. Kerr. Search for other works by this author on: Oxford Academic PubMed Google Scholar John M. Lehman John M. Lehman 5Department of Pathology, University of Colorado Medical Center. 6We thank Mrs. Evelyn Read, Mrs. Gail Thurman, and Miss Pat Poche for their skilled technical assistance. Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 62, Issue 3, March 1979, Pages 633–638, https://doi.org/10.1093/jnci/62.3.633 Published: 01 March 1979 Article history Received: 29 June 1978 Accepted: 21 September 1978 Published: 01 March 1979
Computerised data collection systems have not improved data collection
Authors: J L Burton
Journal: BMJ (1995)

<h3>Background</h3> Chemical disinfectants have traditionally been used to clean pharmaceutical facilities to ensure acceptable microbiological conditions. However, the use of such agents are costly, time-consuming and environmentally undesirable. Exchanging the disinfectants with sterile water and composite fibre cloths was tested in a class A hospital pharmacy compounding environment with regard to their effects on microbiological contamination. <h3>Purpose</h3> The goal of the project was to establish whether an acceptable level of microbiological cleanliness could be upheld in the production facility when cleaning with sterile water and composite fibre cloths instead of traditional chemical disinfectants. <h3>Material and methods</h3> The sterile chemical disinfectants used were an alternating regimen of Klercide Quat/Biguanide, Amine, Sporicidal low residue peroxide and neutral detergent, provided by Ecolab (St Paul, MN, USA). The alternative system, consisting of sterile water and composite fibre cloths, was provided by De forenede dampvaskerier (Viima, Maribo, Denmark). Klercide Sterile 70% ethanol (Ecolab, St Paul, MN, USA) was used for disinfection of grade A between each production, and for surface disinfection of materials to be transferred into grade A. The effect of cleaning methods was compared for four pharmaceutical isolators and two biological safety cabinets, all of class A grade. The quality of the microbiological conditions was monitored with glove prints, settle plates and contact plates (Tryptone Soya Agar, Oslo University Hospital, Oslo, Norway). The rate of contaminated tests (≥1 cfu/plate) for glove prints, settle plates and contact plates in class A in a 24 month period before and after the change in cleaning method were compared. <h3>Results</h3> The rate of contaminated tests were comparable for the 24 month period before and after the change in cleaning method. The rate of positive tests (≥1 cfu/plate) were for glove prints 5.3% before (n=1562) and 5.0% after (n=1584), settle plates 3.2% before (n=809) and 3.0% after (n=824) and contact plates 2.7% before (n=807) and 1,5% after (n=817). <h3>Conclusion</h3> The level of microbiological contamination in a class A hospital pharmacy compounding environment is maintained when cleaning with sterile water and composite fibre cloths, compared to traditional cleaning with chemical disinfectants. <h3>References and/or acknowledgements</h3> None. No conflict of interest.