tbuckley/cabot-search huggingface dataset:
The borderline personality and transitional relatedness
Authors: P H Arkema
Journal: American Journal of Psychiatry (1981)

Borderline patients may be distinguished from patients with personality disorders through the former's use of transitional objects. The transitional relatedness of the borderline patient is generally rigid and maladaptive. By comparison, transitional relatedness, both past and present, is essentially absent in patients with severe character disorders. The borderline patient's capacity for transitional relatedness indicates achievement of a developmental level that has implications for diagnostic classification and psychotherapeutic strategy.
Abstract P2-14-10: Technical results and complication rates after nipple-sparing mastectomy and direct-to-implant breast reconstruction using porcine acellular dermal matrix for implant coverage
Authors: Roland Reitsamer, Florentia Peintinger
Journal: Cancer Research (2015)

Abstract Objective: To evaluate the feasibility and complication rates of nipple-sparing mastectomy (NSM) and direct-to-implant breast reconstruction using a porcine acellular dermal matrix (ADM) for implant coverage. Methods: NSM and direct-to-implant breast reconstruction using a porcine ADM for implant coverage was performed in a series of 91 breasts in 63 patients. Technical results, complications, and cosmetic results were collected from patient records. Results: Short-term complications within one month comprised minor complications as minimal nipple necrosis in 13.2%, and infection in 1.1%. Major complications, as hemorrhage with surgical evacuation in 4.4%, and implant loss due to skin breakdown in 4.4%, totaled in 8.8%. Within three months after primary surgery 3 further severe complications with reoperation ocurred. In 87.9% no second surgical intervention was necessary and cosmetic results were good or excellent. After a mean follow-up of 12 months (range 5 - 35 months) no further complications could be observed. Patient satisfaction was high for 92.3% of the patients and subjective cosmetic result was excellent in 90.1% and satisfactory in 2.2%. Conclusion: Direct-to-implant breast reconstruction using a porcine ADM for implant coverage after NSM is an innovative approach resulting in a high patient satisfaction. The technique is challenging but feasible and complication rates are acceptably low. Citation Format: Roland Reitsamer, Florentia Peintinger. Technical results and complication rates after nipple-sparing mastectomy and direct-to-implant breast reconstruction using porcine acellular dermal matrix for implant coverage [abstract]. In: Proceedings of the Thirty-Seventh Annual CTRC-AACR San Antonio Breast Cancer Symposium: 2014 Dec 9-13; San Antonio, TX. Philadelphia (PA): AACR; Cancer Res 2015;75(9 Suppl):Abstract nr P2-14-10.
Abstract 227: The Effects of Obligatory Training on Attitudes Toward Performing Basic Life Support with Reference to Prior Training Experience
Authors: Miki Enami, Yutaka Takei, Yoshio Tanaka, Daiki Nishi, Keiko Takase, Hideo Inaba
Journal: Circulation (2011)

Backgrounds and aim The effects of BLS training on willingness to perform practicable actions in basic life support (BLS) have not been well studied. This study is conducted to determine the effects of an obligatory BLS training on attitude of the participants towards performing basic life support (BLS). Methods We gave a questionnaire to attendants of the courses for BLS in authorised driving schools. The questionnaire included questions about participants' backgrounds. The questionnaire explored the participant's willingness to perform BLS in four hypothetical scenarios related to early emergency call, CPR on their own initiative, telephone-assisted chest compressions and use of AED, respectively. The questionnaire survey was conducted in the two terms after revision of Japanese guidelines. The questionnaire was given at the beginning in the first term and at the end of course in the second term. Results (see Table) The BLS training augmented the proportions of willingness to use an AED and to perform favorable actions in all scenarios in all attendants with and without prior training, and the proportion to perform the CPR on their own initiative only in attendants without prior training. However, the training failed to increase the proportion of respondents willing to follow telephone-assisted instruction of chest compressions in all respondents with and without prior training. These observations were confirmed by multiple logistic regression analysis including backgrounds of attendants. Analysis of reasons for unwillingness and the actions that negative respondents answered to take suggested that obligatory training increases the confidence of their skill but augments a fear of misjudgment and reliance on other's judgment. Conclusions Obligatory BLS trainings and prior training experiences differently affect the attitude towards BLS. The training should be modified for attendants to gain the confidence of judgment in practical situations.
Abstract 19680: Age but not Body Mass Index (BMI) or Sex Affect Glycemic Response to a Single Food in Healthy Subjects
Authors: Nirupa R Matthan, Janey Ronxhi, Lynne M Ausman, John L Griffith, Anastassios G Pittas, Alice H Lichtenstein
Journal: Circulation (2010)

Introduction: Few large-scale studies have evaluated the variability of glycemic index (GI) value determinations among individuals, particularly on the basis of biological parameters such as sex, a...
<i>BRAF</i>in early stage melanoma: rationale for testing and treatment?
Authors: M.A. Davies
Journal: British Journal of Dermatology (2015)

Journal Article BRAF in early stage melanoma: rationale for testing and treatment? Get access M.A. Davies M.A. Davies University of Texas MD Anderson Cancer Center Houston TX 77030 U.S.A Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 173, Issue 1, 1 July 2015, Pages 9–10, https://doi.org/10.1111/bjd.13926 Published: 01 July 2015
Active Tracing and Monitoring of Contacts Associated With the First Cluster of Ebola in the United States
Authors: Wendy M. Chung, Jessica C. Smith, Lauren M. Weil, Sonya M. Hughes, Sibeso N. Joyner, Emily M. Hall, Julia Ritch, Divya Srinath, Edward Goodman, Michelle S. Chevalier, Lauren Epstein, Jennifer C. Hunter, Alexander J. Kallen, Mateusz P. Karwowski, David T. Kuhar, Charnetta Smith, Lyle R. Petersen, Barbara E. Mahon, David L. Lakey, Stephanie J. Schrag
Journal: Annals of Internal Medicine (2015)

Following hospitalization of the first patient with Ebola virus disease diagnosed in the United States on 28 September 2014, contact tracing methods for Ebola were implemented.To identify, risk-stratify, and monitor contacts of patients with Ebola.Descriptive investigation.Dallas County, Texas, September to November 2014.Contacts of symptomatic patients with Ebola.Contact identification, exposure risk classification, symptom development, and Ebola.The investigation identified 179 contacts, 139 of whom were contacts of the index patient. Of 112 health care personnel (HCP) contacts of the index case, 22 (20%) had known unprotected exposures and 37 (30%) did not have known unprotected exposures but interacted with a patient or contaminated environment on multiple days. Transmission was confirmed in 2 HCP who had substantial interaction with the patient while wearing personal protective equipment. These HCP had 40 additional contacts. Of 20 community contacts of the index patient or the 2 HCP, 4 had high-risk exposures. Movement restrictions were extended to all 179 contacts; 7 contacts were quarantined. Seven percent (14 of 179) of contacts (1 community contact and 13 health care contacts) were evaluated for Ebola during the monitoring period.Data cannot be used to infer whether in-person direct active monitoring is superior to active monitoring alone for early detection of symptomatic contacts.Contact tracing and monitoring approaches for Ebola were adapted to account for the evolving understanding of risks for unrecognized HCP transmission. HCP contacts in the United States without known unprotected exposures should be considered as having a low (but not zero) risk for Ebola and should be actively monitored for symptoms. Core challenges of contact tracing for high-consequence communicable diseases included rapid comprehensive contact identification, large-scale direct active monitoring of contacts, large-scale application of movement restrictions, and necessity of humanitarian support services to meet nonclinical needs of contacts.None.
The Body and Surgery in the Middle Ages
Authors: Roger French
Journal: Annals of Internal Medicine (1991)

of Jacquart's book on sexuality in the Middle Ages: clearly Polity Press have found a niche in the English-reading market.Ultimately, I think, Pouchelle's book can best be described as political.It aims to show, by doing it, that this kind of history is valid.It is partly defensive, the enemies being Anglo-Saxons (particularly in their adoption of "behaviourist" attitudes) and the rational positivism of modern doctors (which tries to dictate what was "scientific" in the Middle Ages).In opposition to this somewhat bloodless and external approach, the validity of the French treatment that Pouchelle is fighting to promote relies on getting inside Henri de Mondeville and re-creating his motives for action.Pouchelle uses a number of devices to do this.The first is the Unconscious "gleanings from the psychologist's couch"-that is, a largely psychoanalytic approach that points to enduring patterns in the mind, together with the "day-to-day workings of my own unconscious as detected in the phantoms and dreams aroused by Mondeville's text itself".The second is a Bachelardian study of the "anthropological structure of the imagination".Third is a systematic study of the power and significance of the analogies, similes, metaphors, and allegories used by Henri.The selection of material to receive emphasis in these approaches is generally made from a feminist viewpoint.It is also a feature of the work that these approaches have been illuminated by reference more to contemporary literary, religious, juridical, and iconographic materials, which "give us access to the medieval imagination" than to other medico-surgical works.So it is certainly not behaviourist or positivist.It is another enterprise.So to criticize it as misdirected would be grossly chauvinistic and Anglo-Saxon.But it may not be inappropriate to point out some consequences of these different techniques.Whatever the justice in seeing a long
A novel point-of-care enoxaparin monitor for use during percutaneous coronary intervention
Authors: David J. Moliterno, James B. Hermiller, Dean J. Kereiakes, Eric Yow, Robert J. Applegate, Gregory A. Braden, Eric J. Dippel, Mark I. Furman, Cindy L. Grines, Neal S. Kleiman, Glenn N. Levine, Tift Mann, Ravi N. Nair, Ronald A. Stine, Steven J. Yacubov, James E. Tcheng
Journal: Journal of the American College of Cardiology (2003)
Guidelines for the definition of time-to-event end points in renal cell cancer clinical trials: results of the DATECAN project
Authors: A. Kramar, S. Negrier, R. Sylvester, S. Joniau, P. Mulders, T. Powles, A. Bex, F. Bonnetain, A. Bossi, S. Bracarda, R. Bukowski, J. Catto, T.K. Choueiri, S. Crabb, T. Eisen, M. El Demery, J. Fitzpatrick, V. Flamand, P.J. Goebell, G. Gravis, N. Houédé, D. Jacqmin, R. Kaplan, B. Malavaud, C. Massard, B. Melichar, L. Mourey, P. Nathan, D. Pasquier, C. Porta, D. Pouessel, D. Quinn, A. Ravaud, F. Rolland, M. Schmidinger, B. Tombal, D. Tosi, E. Vauleon, A. Volpe, P. Wolter, B. Escudier, T. Filleron, Andrew Kramar, Richard Sylvester, Thomas Filleron, Sylvie Negrier, Steven Joniau, Peter Mulders, Thomas Powles, Bernard Escudier, Axel Bex, Franck Bonnetain, Alberto Bossi, Sergio Braccarda, Ronald Bukowski, James Catto, Toni Choueiri, Simon Crabb, Tim Eisen, Mounira El Demery, John Fitzpatrick, Vincent Flamand, Peter J. Goebell, Gwendael Gravis, Nadine Houédé, Didier Jacqmin, Richard Kaplan, Bernard Malavaud, Christophe Massard, Bohuslav Melichar, Loïc Mourey, Paul Nathan, David Pasquier, Camillo Porta, Damien Pouessel, David Quinn, Alain Ravaud, Frédéric Rolland, Manuela Schmidinger, Bertrand Tombal, Diego Tosi, Elodie Vauleon, Alessandro Volpe, Pascal Wolter
Journal: Annals of Oncology (2015)
Evidence of Atrial Functional Mitral Regurgitation Due to Atrial Fibrillation
Authors: Zachary M. Gertz, Amresh Raina, Laszlo Saghy, Erica S. Zado, David J. Callans, Francis E. Marchlinski, Martin G. Keane, Frank E. Silvestry
Journal: Journal of the American College of Cardiology (2011)
Abstract 5530: Predominant Types of Dyslipidemia in U.S. Adults with Coronary Heart Disease and Diabetes
Authors: Nathan D Wong, Heli Ghandehari, Hoangvy Le, Baishali M Ambegaonkar, Vasilisa Sazonov
Journal: Circulation (2008)

Background: The prevalence of isolated (one lipid disorder) and mixed (≥2 lipid disorders) dyslipidemia has not been well-chararacterized, particularly among patients with coronary heart disease (CHD) and type 2 diabetes mellitus (DM). We examined the association between types of dyslipidemia and CHD or DM among a representative sample of US adults. Methods: We studied 2,827 adults with complete lipid data for LDL-C, HDL-C and triglycerides (TG) representing 126 million US adults in the National Health and Nutrition Examination Survey (NHANES) 2003–2004. We determined the prevalence of elevated LDL-C (as per NCEP guidelines), low HDL-C (&lt;40 mg/dL for men and &lt;50 mg/dL for women) and/or elevated TG (≥200 mg/dL) among those with CHD (n=134) or DM (n=277). Multivariate logistic regression examined the association between CHD or DM and types of dyslipidemia while controlling for clinical and demographic characteristics. Results: Overall, 74% with CHD and 80% of those with DM had ≥1 lipid disorder. Among CHD patients, 60%, 27% and 27% had elevated LDL-C, low HDL-C and elevated TG respectively, while 20% had 2 lipid disorders and 10% had all 3. Among DM patients, 65%, 40% and 22% had elevated LDL-C, low HDL-C, and elevated TG respectively, while 29% had 2 lipid disorders and 10% had all 3. Compared to those with no lipid disorder, the odds of CHD were 4–6 times greater with elevated LDL-C combined with elevated TG regardless of HDL-C. In contrast, the odds of DM were the greatest in those with elevated LDL-C and low HDL-C regardless of TG. Other types of dyslipidemia were less strongly or not associated with CHD or DM (Table ). Conclusions: In this representative sample of US adults, CHD was most closely associated with elevated LDL-C combined with elevated TG regardless of HDL-C levels, while DM was most closely associated with elevated LDL-C and low HDL-C regardless of TG levels. These differences should be considered when choosing therapies for dyslipidemia in patients with CHD and DM. Multivariable Adjusted Odds of Coronary Heart Disease (CHD) or Diabetes (DM) by Lipid Disorder
Psychological outcome of lumpectomy versus mastectomy in the treatment of breast cancer
Authors: Steinberg, Juliano Ma, Wise L
Journal: American Journal of Psychiatry (1985)

Forty-six patients who underwent modified radical mastectomy were compared 14 months after surgery with 21 patients who underwent lumpectomy and radiation; all patients had stage I or II breast cancer. Lumpectomy patients reported less of a loss of feelings of attractiveness and femininity, were less self-conscious about their appearance, received more emotional support from friends, and were more open about their surgery and sexual feelings after surgery. Unlike the mastectomy patients, they saw their spouses' sexuality as enhanced after surgery. Lumpectomy patients were not less anxious or less depressed but showed better overall adaptation to their surgery and less functional change.
Differences in presentation and progression between severe FIC1 and BSEP deficiencies
Authors: Ludmila Pawlikowska, Sandra Strautnieks, Irena Jankowska, Piotr Czubkowski, Karan Emerick, Anthony Antoniou, Catherine Wanty, Bjorn Fischler, Emmanuel Jacquemin, Sami Wali, Samra Blanchard, Inge-Merete Nielsen, Billy Bourke, Shirley McQuaid, Florence Lacaille, Jane A. Byrne, Albertien M. van Eerde, Kaija-Leena Kolho, Leo Klomp, Roderick Houwen, Peter Bacchetti, Steven Lobritto, Vera Hupertz, Patricia McClean, Giorgina Mieli-Vergani, Benjamin Shneider, Antal Nemeth, Etienne Sokal, Nelson B. Freimer, A.S. Knisely, Philip Rosenthal, Peter F. Whitington, Joanna Pawlowska, Richard J. Thompson, Laura N. Bull
Journal: Journal of Hepatology (2010)
Usefulness of matrix-assisted laser desorption ionisation–time-of-flight mass spectrometry for identifying clinical Trichosporon isolates
Authors: J.N. de Almeida Júnior, D.S.Y. Figueiredo, D. Toubas, G.M.B. Del Negro, A.L. Motta, F. Rossi, J. Guitard, F. Morio, E. Bailly, A. Angoulvant, D. Mazier, G. Benard, C. Hennequin
Journal: Clinical Microbiology and Infection (2013)
Abstract #5607: Employing functional genomics to reveal emergent dependencies supporting tumorigenic regulatory networks
Authors: Angelique Whitehurst, Scott Purinton, Crisy Roland, Rolf Brekken, Yang Xie, John Schorge, Michael White
Journal: Cancer Research (2009)

AACR Annual Meeting-- Apr 18-22, 2009; Denver, CO

We are using genome-wide loss of function screens in tumor cells to deconstruct the aberrant regulatory networks that develop during tumor evolution. Using this approach, we have identified a group of genes required for tumor cell proliferation and survival whose expression is normally restricted to tissues involved in gametogenesis. While studies focused on identifying aberrant gene expression patterns in tumors have previously correlated the presence of these genes with the tumorigenic state, this functional genomics approach has revealed an acute causal relationship with tumorigenic behavior. Specifically, we have revealed a dependency on the cancer testis antigen, acrosin binding protein (ACRBP), for mitotic fidelity in tumor, but not normal cells. Depletion of ACRBP across a panel of ovarian cancer lines results in inhibition of proliferation or apoptosis depending upon co-occuring genetic abberations. Mechanistic studies suggest that ACRBP supports centrosomal coalescence, allowing tumor cells to complete mitosis, despite the presence of supernumerary centrosomes. Loss of ACRBP prevents centrosomal clustering, leading to multiple gamma-tubulin and Aurora-A kinase positive microtubule organizing centers. This phenotype is accelerated and leads to an aberrant mitosis in the presence of a low, otherwise non-toxic, dose of paclitaxel. Strikingly, 70 % of ovarian tumors have activated ACRBP expression. Using a panel of 29 ovarian tumor samples we determined that ACRBP expression is inversely correlated with patient survival (p=.0009). Thus, we suggest that the products of aberrant gene expression programs activated during tumor evolution can become conditional dependencies that support fitness in the presence of insults, such as genotoxic stress. ACRBP may be one such gene, which, in the tumorigenic state, functions to support a robust mitosis despite the hallmark chromosomal instability of cancer cells.

Citation Information: In: Proc Am Assoc Cancer Res; 2009 Apr 18-22; Denver, CO. Philadelphia (PA): AACR; 2009. Abstract nr 5607.
A foodborne outbreak of norovirus gastroenteritis associated with a Christmas dinner in Porto, Portugal, December 2008
Authors: J R Mesquita, M S Nascimento
Journal: Eurosurveillance (2009)

An outbreak of acute norovirus gastroenteritis was detected and epidemiologically linked to a Christmas dinner reunion of 22 recent graduate students in a restaurant in Porto, Portugal, in December 2008. A retrospective cohort study was carried out using online standardised questionnaires. Sixteen primary and three secondary cases were identified and the risk ratios with 95% confidence intervals for each food item were calculated. The response rate to the online questionnaires was 96%. The outbreak met all four Kaplan’s criteria and the attack rate was 73%. Norovirus GII.4 2006b was detected in stools and emesis samples of two primary cases. The ingestion of soup and lettuce salad was considered a risk factor for this norovirus outbreak, as determined by statistical analysis. Our investigation demonstrated two routes of transmission of norovirus starting with foodborne exposure followed by secondary person-to-person spread. To our knowledge this is the first study identifying norovirus as the causative agent of a foodborne outbreak in Portugal.
Physiology is a better predictor of mortality than HRTC findings in patients with fibrotic idiopathic interstitial pneumonia
Authors: Federica Novelli, Laura Tavanti, Federica Martino, Stella Cini, Lorenza Melosini, Chiara Romei, Fabio Falaschi, Stefano Solfanelli, Alessandro Celi, Pierluigi Paggiaro
Journal: European Respiratory Journal (2011)

Background:  Prognosis of fibrotic idiopathic interstitial pneumonia (IIP) is influenced not only by the histologic pattern observed in lung biopsy but also by high resolution chest tomography (HRCT) and pulmonary function findings.   Aim:  To evaluate if functional parameters are better predictors of mortality that HRCT findings in patients with fibrotic IIP.   Methods:  We studied 43 patients with fibrotic IIP during a follow-up of 37.2±31.7 months after diagnosis. Baseline HRCT was evaluated for different abnormalities: honeycombing (HC), reticulation, ground-glass, bronchiectasis and total fibrotic score. Pulmonary function was assessed as baseline FVC and change of FVC after 6 months of follow-up (less or more 10%).   Results:  Among the different HRCT scores, a cut-off of 10% in the HC score differentiated patients with different survival (5-yrs survival 41% vs 90%, p=0.04). Patients with HC > 10% had a longer duration of symptoms (p=0.04), a lower baseline DLCO (% of predicted, p=0.006) and higher fibrotic and bronchiectasis score (respectively, p=0.04 and p   Conclusion:  Functional findings are more important prognostic factors of mortality than HRCT parameters in patients with fibrotic IIP.
Clinical and epidemiological aspects of parvovirus B19 infections in Ireland, January 1996-June 2008
Authors: N Nicolay, S Cotter
Journal: Eurosurveillance (2009)

Parvovirus B19 infection may be mistakenly reported as measles or rubella if laboratory testing is not performed. As Europe is seeking to eliminate measles, an accurate diagnosis of fever/rash illnesses is needed. The main purpose of this study was to describe the epidemiological pattern of parvovirus B19, a common cause of rash, in Ireland between January 1996 and June 2008, using times series analysis of laboratory diagnostic data from the National Virus Reference Laboratory. Most diagnostic tests for presumptive parvovirus B19 infection were done in children under the age of five years and in women of child-bearing age (between 20-39 years-old). As a consequence, most of the acute diagnoses of B19 infection were made in these populations. The most commonly reported reasons for testing were: clinical presentation with rash, acute arthritis, influenza-like symptoms or pregnancy. The time series analysis identified seasonal trends in parvovirus B19 infection, with annual cycles peaking in late winter/spring and a six-year cycle for parvovirus B19 outbreaks in Ireland.