tbuckley/cabot-search huggingface dataset:
Side Effects of Ibuprofen
Authors: ROBERT D. BRANDSTETTER
Journal: Annals of Internal Medicine (1980)

Letters1 April 1980Side Effects of IbuprofenROBERT D. BRANDSTETTER, M.D., DEXTER D. MAR, PHARM. D.ROBERT D. BRANDSTETTER, M.D.Search for more papers by this author, DEXTER D. MAR, PHARM. D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-92-4-569_3 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: In his otherwise excellent review of ibuprofen (1), Dr. Kantor has omitted adverse renal side effects when he discusses this drug's adverse effects. Over the last 2 years, significant attention has been directed towards deterioration of renal function caused by nonsteroidal anti-inflammatory drugs, including ibuprofen (2-5). The mechanism of the renal dysfunction is believed to involve renal prostaglandin synthetase inhibition with resulting alteration in renal hemodynamics (2)....References1. KANTOR T. Ibuprofen. Ann Intern Med. 1979;91:877-82. LinkGoogle Scholar2. KIMBERLY R, BOWDEN R, KEISER H, and PLOTZ P. Reduction of renal function by newer nonsteroidal anti-inflammatory drugs. Am J Med. 1978;64:804-7. CrossrefMedlineGoogle Scholar3. BREZIN J, KATZ S, SCHWARTZ A, and CHINITZ J. Reversible renal failure and nephrotic syndrome associated with nonsteroidal anti-inflammatory drugs. N Engl J Med. 1979;301:1271-3. CrossrefMedlineGoogle Scholar4. BRANDSTETTER R and MAR D. Reversible oliguric renal failure associated with ibuprofen treatment. Br Med J. 1978;2:1194-5. CrossrefMedlineGoogle Scholar5. KIMBERLY R and BRANDSTETTER R. Exacerbation of phenylbutazone-related renal failure by indomethacin. Arch Intern Med. 1978;138:1711-2. CrossrefMedlineGoogle Scholar1. KANTOR T. Ibuprofen. Ann Intern Med. 1979;91:877-82. LinkGoogle Scholar2. STERNLIEB P and ROBINSON R. Stevens-Johnson syndrome plus toxic hepatitis due to ibuprofen. NY State J Med. 1978;78:1239-43. MedlineGoogle Scholar3. STEMPEL D and MILLER J. Lymphopenia and hepatic toxicity with ibuprofen. J Pediatr. 1977;90:657-8. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: ROBERT D. BRANDSTETTER, M.D.; DEXTER D. MAR, PHARM. D.Affiliations: The New York Hospital-Cornell University Medical Center New York, NY 10021 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 April 1980Volume 92, Issue 4Page: 569-570KeywordsAdverse reactionsDrugsHemodynamicsIbuprofenLigasesProstaglandin ePublished: 1 December 2008 Issue Published: 1 April 1980 PDF downloadLoading ...
Late onset of autoimmune hemolytic anemia and pure red cell aplasia after allogeneic hematopoietic stem cell transplantation using in vivo alemtuzumab
Authors: Shinichi Kako, Yoshinobu Kanda, Kumi Oshima, Nahoko Nishimoto, Hiroyuki Sato, Takuro Watanabe, Noriko Hosoya, Toru Motokura, Shigesaburo Miyakoshi, Shuichi Taniguchi, Aki Kamijo, Koki Takahashi, Shigeru Chiba, Mineo Kurokawa
Journal: American Journal of Hematology (2007)

Abstract Hemolytic anemia and pure red cell aplasia (PRCA) after allogeneic hematopoietic stem cell transplantation (HSCT) have been reported to be mainly related to ABO‐incompatibility between donor and recipient. Autoimmune hemolytic anemia (AIHA) without ABO‐incompatibility has been also reported after allogeneic HSCT, especially with T‐cell depletion. However, optimal management of AIHA or PRCA remains unclear. A 54‐year‐old male with myelodysplastic syndrome (MDS) underwent haploidentical human leukocyte antigen‐mismatched HSCT using in vivo alemtuzumab and developed AIHA and PRCA simultaneously 15 months after transplantation, following the administration of cidofovir and probenecid for persistent cytomegalovirus (CMV) antigenemia and retinitis. AIHA was successfully treated with rituximab, and subsequently PRCA with cyclosporine without relapse of MDS or recurrence of CMV infection. The clinical course suggested that AIHA was mainly caused by humoral immune response, while PRCA was mainly caused by cell‐mediated immune response in this patient, although these immune responses might be related to each other. Am. J. Hematol., 2008. © 2007 Wiley‐Liss, Inc.
Radioiodine for Hyperthyroidism
Authors: David S. Cooper
Journal: JAMA (1998)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
ABNORMALITIES OF THE FINGER NAILS ASSOCIATED WITH IMPAIRED PERIPHERAL BLOOD SUPPLY.
Authors: PETER D. SAMMAN, BASIL STRICKLAND
Journal: British Journal of Dermatology (1962)

Journal Article ABNORMALITIES OF THE FINGER NAILS ASSOCIATED WITH IMPAIRED PERIPHERAL BLOOD SUPPLY. Get access PETER D. SAMMAN, M.D., M.R.C.P., PETER D. SAMMAN, M.D., M.R.C.P. Physician for Diseases of the Skin, Westminster Hospital, London, S.W.I, and the Institute of Dermatology, St. John's Hospital, Lisle Street, London, W.C.I Search for other works by this author on: Oxford Academic Google Scholar BASIL STRICKLAND, M.B., B.S., M.R.C.P., F.F.R. BASIL STRICKLAND, M.B., B.S., M.R.C.P., F.F.R. Radiologist, Westminster Hospital, London, S.W.I Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 74, Issue 5, 1 May 1962, Pages 165–173, https://doi.org/10.1111/j.1365-2133.1962.tb13484.x Published: 01 May 1962
Fatal Complement-Induced Leukostasis After Diatrizoate Injection
Authors: Henry Schneiderman, Dale E. Hammerschmidt, Anne Ritke McCall, Harry S. Jacob
Journal: JAMA (1983)

A case of fatal radiographic contrast medium (RCM)-induced pulmonary granulocyte aggregation (leukostasis) showed massive elevation of the postmortem histamine level. Suspicion of this phenomenon in diverse clinical settings permits clinical and pathological documentation via increased plasma levels of C3a and other means. The existence of effective prophylaxis stimulates a search for predictive tests. (<i>JAMA</i>1983;250:2340-2342)
Drug-induced expansion of infarct: morphologic and functional correlations.
Authors: H Hammerman, F J Schoen, E Braunwald, R A Kloner
Journal: Circulation (1984)

It has been established that glucocorticoids and several nonsteroidal antiinflammatory drugs, when administered early after coronary occlusion, interfere with myocardial scar formation. To determine whether this action is associated with expansion of myocardial infarct during the first week of coronary occlusion and whether expansion affects ventricular function, the effects of indomethacin on the left ventricle in the early phase of infarction were studied. In a blinded randomized study, experimental myocardial infarction was produced in 17 open-chest dogs by ligation of the proximal left anterior descending coronary artery; the treated group (n = 8) received 10 mg/kg iv indomethacin at 15 min and 3 hr after occlusion, and the control group (n = 9) received saline. After 7 days, regional function expressed as percent change of area (% delta A) of the left ventricular cavity was calculated from short-axis two-dimensional echocardiograms at the level of the infarct, the animals were killed, and their hearts were examined. The ratio of infarct thickness to noninfarcted wall thickness was 1.20 +/- 0.08 (mean +/- SEM) in the control group, and the ratio was lower in the indomethacin group, 0.96 +/- 0.04 (p less than .025). An expansion index of myocardial infarction was calculated as previously described and was 1.02 +/- 0.04 in the control group vs 1.29 +/- 0.06 in the indomethacin group (p less than .005). In eight dogs (six control and two treated) without expansion (expansion index less than 1.09), regional function expressed as % delta A was 46.8 +/- 2.6% (SEM), and in nine dogs (six treated and three control) with expansion, % delta A was significantly lower, 28.7 +/- 4.0% (p less than .005).(ABSTRACT TRUNCATED AT 250 WORDS)
1190 STUDY OF ABT-267 2-DAY MONOTHERAPY FOLLOWED BY 12-WEEK COMBINATION THERAPY IN TREATMENT-NAÏVE PATIENTS WITH CHRONIC HCV GENOTYPE 1 INFECTION
Authors: M. Epstein, F. Felizarta, T. Marbury, P. Badri, V. Mullally, T. Pilot-Matias, X. Liu, C.M. Setze, A.L. Campbell, B. Bernstein
Journal: Journal of Hepatology (2013)
Children's Reactions to Temporary Loss of the Father
Authors: FRANK E. CRUMLEY, RONALD S. BLUMENTHAL
Journal: American Journal of Psychiatry (1973)

The impact of separation from a parent is recognized as a crucial factor in a child's development. Forced military separations also lead to clinically observable reactions in children. This long-term loss of the father is considered a developmental interference resulting in a disturbance in the typical unfolding of the child's personality. Important treatment considerations flow from understanding the impact this has on the child.
Comparison of airway and peripheral blood T cell characteristics in severe asthma and COPD*1
Authors: J.C. Ratoff, M.I. Allenby, M.W. Lethbridge, W. Turnbull, A.C.L. Cheung, T. Snape, A.C. Hayday, C.J. Corrigan, B.J. O'Connor
Journal: Journal of Allergy and Clinical Immunology (2004)
The Diabetes Project at Fort Totten, North Dakota, 1984–1988
Authors: William P Newman, Jackie J Hollevoet, Karen L Frohlich
Journal: Diabetes Care (1993)

To characterize demographic, therapeutic, and complication features of patients in the Fort Totten Diabetes Project and to assess the longitudinal impact of intervention strategies.Individuals (n = 215) of varying American Indian ethnic origin and a quantum of mean age 53 yr (range 14-86 yr), 62% women, with type II diabetes of 9 yr average duration were studied. Annual chart audits of the complete diabetic population were conducted from 1984 to 1988.Obesity is a major problem complicating diabetes management (average BMI 32 +/- 0.9), but BMI does not correlate with glucose control as assessed by total GHb (r = 0.014, NS). Individuals lost an average of 3.7 kg (P < 0.001) during the audit years. Mean GHb declined for the population (11.3-9.7%, P < 0.025) during the interval, but no significant decline was evident when values for individuals were considered. Complication rates for retinopathy, nephropathy, and neuropathy paralleled those rates published for urban populations.Diabetes mellitus in American Indians living in a rural, economically deprived area can be identified and cared for with success similar to that published for urban populations.
Pathogenic molds (including Aspergillus species) in hospital water distribution systems: a 3-year prospective study and clinical implications for patients with hematologic malignancies
Authors: Elias J. Anaissie, Shawna L. Stratton, M. Cecilia Dignani, Choon-kee Lee, Richard C. Summerbell, John H. Rex, Thomas P. Monson, Thomas J. Walsh
Journal: Blood (2003)
The action of sennosides and related compounds on human colon and rectum
Authors: J. D. Hardcastle, J. L. Wilkins
Journal: Gut (1970)

The direct action of intraluminal senna and related compounds on the human colon and rectum has been investigated. Motility was recorded by balloon kymography with recording units inserted into well established transverse colostomies or into the rectum. The motility of the colon was not changed by intraluminal senna glycosides but the introduction of senna previously incubated with faeces or <i>Esch. coli</i> stimulated the colon to peristalt. The peristalsis was similar to that stimulated by rheinanthrone, an oxanthrone produced by chemical hydrolysis and reduction of senna. Both activated senna and rheinanthrone appeared to act in the colon by contact stimulation. No peristaltic response was stimulated in the rectum, either with activated senna or with rheinanthrone.
Edward Crosby Field
Authors: I. Hesketh
Journal: BMJ (2003)

Former general practitioner Blackwell, Derbyshire (b Barbados 1916; q Edinburgh 1941), d 30 March 2003.​2003.




Figure 1




He settled in singlehanded general practice in Blackwell, Derbyshire, in 1946, retiring in 1960. He moved to Eastbourne, continuing with his great interest in cricket and latterly solving crosswords. He died peacefully in Eastbourne District General Hospital after a fall at home. He leaves a wife, Margaret (Peggy), and a daughter, Elizabeth.
Diagnostic Significance of Dental History in the Clinical Evaluation of Patients with Thyroid Carcinoma
Authors: GARY HERZOG, GREGORY KISLING, CARLOS BEKERMAN
Journal: Clinical Nuclear Medicine (1992)

A whole body scan after the administration of 10 mCi of I-131 was performed on a 45-year-old woman who 1 year earlier had a partial thyroidectomy and a therapeutic dose of 150 mCi of I-131 for follicular thyroid carcinoma. An area of increased activity was demonstrated in the left side of the neck on the 24-hour and 48-hour images, thought to represent a functioning thyroid metastasis. Oral examination and medical history revealed significant dental disease and recent periodontal surgery of the left maxilla. The area of abnormal uptake was, therefore, attributed to a combination of dental disease and peridontal surgery.
Deregulated gene expression pathways in myelodysplastic syndrome hematopoietic stem cells
Authors: A Pellagatti, M Cazzola, A Giagounidis, J Perry, L Malcovati, M G Della Porta, M Jädersten, S Killick, A Verma, C J Norbury, E Hellström-Lindberg, J S Wainscoat, J Boultwood
Journal: Leukemia (2010)
Is the incidence of hypospadias increasing? Analysis of Finnish hospital discharge data 1970-1994.
Authors: M Aho, A M Koivisto, T L Tammela, A Auvinen
Journal: Environmental Health Perspectives (2000)

Reports suggesting an increasing incidence of male genitourinary anomalies such as hypospadias, possibly related to environmental factors such as environmental estrogen-like compounds, have recently received considerable publicity. These reports are based on birth defects registry data, and there may be variation in the completeness of the registries used. We analyzed temporal trends in the prevalence of hypospadias in Finland to assess the previously reported low overall prevalence and to detect any possible increasing tendencies during the past decade. We identified all patients who were surgically treated for hypospadias before the age of 9 years among boys born 1970-1986 in the national hospital discharge registry. We calculated the cumulative prevalence by dividing the number of patients by the number of male births, and we used Poisson regression analysis. Out of 549,176 boys born in Finland in 1970-1986, 1,543 were treated for hypospadias by the age of 8 years (28.1 surgically treated patients per 10,000 male live births; 95% confidence interval, 26.7-29.5). The prevalence of hypospadias in Finland remained constant throughout the study period and appears to have been approximately three times higher than previously reported. Changes in completeness of registration may account for a substantial proportion of the reported increases in the prevalence of hypospadias in Finland and possibly also elsewhere.
Aneurysm of Abdominal Aorta in the Newborn Infant
Authors: M. Beckett Howorth
Journal: New England Journal of Medicine (1967)

ANEURYSM of the aorta in children is rare. Aneurysm of the abdominal aorta at birth of a living infant has not been reported. In the following case a large congenital aneurysm of the abdominal aorta was not properly identified until operative rupture occurred.Case BeportA white female infant was born at the Oxford – Lafayette County Hospital, Oxford, Mississippi, On February 7, 1966, after a period of gestation of 34 weeks and spontaneous labor, with a double-footling delivery. The weight 3 days after birth was 3203 gm. (7 pounds, 1 ounce). The mother's age was 22 years, and this . . .
A FURTHER REPORT ON ISCHOCHYMIA (DILATATION OF THE STOMACH).
Authors: MAX. EINHORN
Journal: JAMA (1897)

The President of ourAssociation, Dr. Nicholas Senn, was the first in this country to direct the attention of the profession to the importance of surgical interference in cases of stenosis of the pylorus. In 1891 Senn published in the<i>Medical Record</i>(November 7 and 14) fifteen cases of pyloric stenosis, two of a benignant type and thirteen due to malignant disease (cancer), on which he had operated. In the two cases of benignant stricture the operation consisted in Heinecke-Mikulicz pyloroplasty. In the remaining thirteen, of cancer of the pylorus, gastro-enterostomy was established. In this paper Senn said: "Stricture of the pylorus is a surgical affection and should be treated as such with the same right and for the same reasons as a stricture of the esophagus, rectum or urethra. Reliance on medicine is as deceptive and useless in these cases as in the treatment of stricture of any other
Circumcision and HIV Risk
Authors: Joan Stephenson
Journal: JAMA (2009)

Although observational studies have shown that male circumcision can reduce a man's risk of acquiring HIV infection by 50% to 60%, it does not decrease HIV transmission from a man to female partners, report US and Ugandan researchers (Wawer MJ et al. Lancet. 2009;374[9685]:229-237).
Empiric Therapy for Febrile Neutropenia
Authors: Ben E. DePauw
Journal: Annals of Internal Medicine (1994)

Letters15 October 1994Empiric Therapy for Febrile NeutropeniaBen E. DePauw, MD, PhD and J. Peter Donnelly, MIBiol, PhDBen E. DePauw, MD, PhDSearch for more papers by this author and J. Peter Donnelly, MIBiol, PhDSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-121-8-199410150-00017 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail IN RESPONSE:Dr. Inciardi believes that our report [1] left several issues unanswered. We take this as a compliment, given that the opposite often seems true when few data are tortured until they yield their secrets. The extensive data assembled for this study were far greater than we could hope to include in a single report. In choosing our priorities, we omitted logistic regression analysis because variables such as age, underlying disease, and depth and duration of granulocytopenia were well balanced, as can be seen in Table 1 of our original report, suggesting that any possible effect would be slight. ...References1. De Pauw BE, Deresinski SC, Feld R, Lane-Allman EF, Donnelly JP, for the Intercontinental Antimicrobial Study Group. Ceftazidime compared with piperacillin and tobramycin for the empiric treatment of fever in neutropenic patients with cancer. A multicenter randomized trial. Ann Intern Med. 1994; 120:834-44. Google Scholar2. Feld R, Goodman PJ, Higgins B, De Pauw BE, Deresinski S, Donnelly JP, et al. Prognostic factors predicting for the development of superinfection in febrile neutropenic patients (Abstract). 32nd Interscience Conference on Antimicrobial Agents and Chemotherapy, 11-14 October 1992, Anaheim, California. Google Scholar Author, Article, and Disclosure InformationAffiliations: PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 15 October 1994Volume 121, Issue 8Page: 623-624KeywordsFactor analysisLearning curvesNeutropeniaOdds ratioPerceptionRegression analysisSuperinfections Issue Published: 15 October 1994 CopyrightCopyright © 1994 by American College of Physicians. All Rights Reserved.PDF DownloadLoading ...
Antitrypsin Deficiency in Pulmonary Disease
Authors: ALEX B. LATTY
Journal: Annals of Internal Medicine (1970)

Letters and Comments1 January 1970Antitrypsin Deficiency in Pulmonary DiseaseALEX B. LATTY, M.D.ALEX B. LATTY, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-72-1-147_2 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: In the September 1969 ANNALSWelch and associates make a significant contribution to the antitrypsin literature with the finding of no significant difference in the frequency of "heterozygote" antitrypsin deficiency among healthy persons versus patients with lung disease. However, they then deduce that this observation coupled with the very different clinical lung disease found among heterozygous and homozygous antitrypsin-deficient patients mitigates a significant role for antitrypsin deficiency in pulmonary disease. This conclusion is not warranted by their data. The differences in clinical presentations of their heterozygotes and homozygotes could well reflect a quantitative difference in the severity...References1. LIEBERMAN J: Heterozygous and homozygous alpha1-antitrypsin deficiency in patients with pulmonary emphysema. New Eng J Med 281: 279, 1969. CrossrefMedlineGoogle Scholar2. KUEPPERS K, FALLAT R, and LARSON R: Obstructive lung disease and alpha1-antitrypsin deficiency gene heterozygosity. Science 165: 899, 1969. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: ALEX B. LATTY, M.D.Affiliations: Department of Medicine Duke University Medical Center Durham, N.C. 27706 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byLes antiprotéases du plasma 1 January 1970Volume 72, Issue 1 Page: 147-148 Keywords Lungs Pulmonary diseases ePublished: 1 December 2008 Issue Published: 1 January 1970 PDF downloadLoading ...
Abortion and Unplanned Pregnancy
Authors: Matthew J. Bulfin
Journal: JAMA (2000)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal