THE ORIGIN AND NATURE OF ANISOTROPIC URINARY LIPIDS IN THE NEPROTIC SYNDROME
Authors: J G ZIMMER, R DEWEY, C WATERHOUSE, R TERRY
Journal: Annals of Internal Medicine (1961)

Article1 February 1961THE ORIGIN AND NATURE OF ANISOTROPIC URINARY LIPIDS IN THE NEPROTIC SYNDROMEJAMES G. ZIMMER, M.D., RICHARD DEWEY, M.D., CHRISTINE WATERHOUSE, M.D., F.A.C.P., ROGER TERRY, M.D.JAMES G. ZIMMER, M.D.Search for more papers by this author, RICHARD DEWEY, M.D.Search for more papers by this author, CHRISTINE WATERHOUSE, M.D., F.A.C.P.Search for more papers by this author, ROGER TERRY, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-54-2-205 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptINTRODUCTIONAnisotropic lipid material has been observed in the urine sediment of patients with the nephrotic syndrome since the early 1900s. These globular anisotropic bodies have the well known "Maltese cross" appearance when viewed with a polarizing microscope. This appearance of certain spherical bodies in a liquid medium has caused them to be classified, since about 1905, as "fluid spherocrystals" or "spherulites," and they are felt to be pure crystalline substances in a phase intermediate between the fluid and the crystalline states.1Most of the studies concerning the localization and chemical nature of anisotropic lipids are to be found in...Bibliography1. Schenck : Flüssige Kritalle, Leipzig, 1905. Google Scholar2. Mettenheimer : Correspondence in Bl. d. Verein. F. ges. Arb. z. Förder. d. Wissensch. Heilk 31: 467, 1858. Google Scholar3. StengelAustin AJH: Syphilitic nephritis. Amer. J. Med. Sci. 149: 12, 1915. CrossrefGoogle Scholar4. Munck F: a) Über lipoide Degeneration. Virchows Arch. 194: 527, 1908; b) Klinische Diagnostik der degenerativen Nierenerkrankungen. Z. Klin. Med. 78: 1, 1913; c) Die Nephrosen. Med. Klinik 12: pp. 1019, 1047, 1073, 1916. CrossrefGoogle Scholar5. Brice AT: The incidence of lipoids in urine. J. Lab. Clin. Med. 15: 953, 1930. Google Scholar6. Adami JG: The myelins and potential fluid crystalline bodies of the organism. J. A. M. A. 48: 463, 1907. CrossrefGoogle Scholar7. Windaus A: Über die quantitative Bestimmung des Cholesterins und des Cholesterinester in einigen normales und pathologischen Nieren. Z. Physiol. Chemie 65: 110, 1910. CrossrefGoogle Scholar8. Dunn IS: Nephrosis or nephritis? J. Path. Bact. 39: 1, 1934. CrossrefGoogle Scholar9. Leiter L: Nephrosis. Medicine 10: 135, 1931. CrossrefGoogle Scholar10. Oliver J: New directions in renal morphology: a method, its results and its future. Harvey Lectures 40: 102, 1944-45. Google Scholar11. Allen AC: The clinicopathologic meaning of the nephrotic syndrome. Amer. J. Med. 18: 277, 1955. CrossrefMedlineGoogle Scholar12. MarinettiErblandKochen GVJJ: Quantitative chromatography of phosphatides. Fed. Proc. 16: 837, 1957. MedlineGoogle Scholar13. Burchard H: Beiträge zur Kenntniss der Cholesterine (dissertation, 26 pp.), Rostock, Germany, 1889. Google Scholar14. Addis TF: Glomerular Nephritis, pp. 207-208, The Macmillan Co., N. Y., 1948. Google Scholar15. QuinnZimmerman JRHJ: Significance of oval fat bodies in urinary sediment. Amer. J. Clin. Path. 24: 787, 1954. CrossrefMedlineGoogle Scholar16. SchradlBöhleBecker WEG: Über die Ausscheidung von Lipoprotein im Urin bei den sogenannten Albuminurien. Deut. Arch. Klin. Med. 202: 415, 1955-56. MedlineGoogle Scholar17. Gerard P: Histopathology of the vertebrate nephron. J. Anat. 70: 354, 1935-36. Google Scholar18. SmetanaJohnson HFR: The origin of colloid and lipoid droplets in the epithelial cells of the renal tubules. Amer. J. Path. 18: 1029, 1942. MedlineGoogle Scholar19. WeltmannBiach OP: Zur Frage der experimentellen Cholesteatose. Z. exper. Path. und Therap. 14: 367, 1913. CrossrefGoogle Scholar20. Genck M: Über das vorkommen und die bedeutung droppelbrechender Substangen im Ham. Deut. Arch. Klin. Med. 125: 333, 1918. Google Scholar21. RutsteinIngenitoCraigMartinelli DDEFJMM: Effects of linoleic and stearic acids on cholesterol-induced lipoid deposition in human aortic cells in tissue culture. Lancet 1: 545, 1958. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Rochester, New York*Received for publication July 5, 1960.From the Departments of Medicine and Pathology, University of Rochester School of Medicine and Dentistry, Rochester New York.Drs. Zimmer and Dewey are Associate Residents and Assistants in Medicine; Dr. Waterhouse is Associate Professor of Medicine; and Dr. Terry is Associate Professor of Pathology; University of Rochester School of Medicine and Dentistry, Rochester, New York.†This study was aided by Grant P-138 from the American Cancer Society, and by the Ernest L. Woodward Fund.Requests for reprints should be addressed to Christine Waterhouse, M.D., Associate Professor of Medicine, University of Rochester School of Medicine and Dentistry, 260 Crittenden Boulevard, Rochester 20, New York. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byFactors Associated with Postoperative Lipiduria and Hypoxemia in Patients Undergoing Surgery for Orthopedic FracturesGood response of low-fat/high-protein diet in a patient with chyluriaPathology in PracticeTurbid white urineChyluria presenting as milky urine and nephrotic-range proteinuriaUrinary Doubly Refractile Lipid Bodies in Nonglomerular Renal DiseasesRenal cholesterol granulomas: identification and morphological pattern of developmentUrinary Lipid Bodies in polycystic Kidney DiseaseUrinary cholesterol in cancer screeningSelf-assessment questionsStudies on the clinical significance of nonesterified and total cholesterol in urineCorrelation of total cholesterol and protein in urine in patients with the NEPHROTIC syndromeComparative evaluation of nonesterified and total urinary cholesterol in papilloma and carcinoma of the bladderUrinary cholesterol excretion in men with benign prostatic hyperplasia and carcinoma of the prostateThe interpretation of proteinuria and the urinary sedimentMovement of lipids into and out of the blood during hyperlipidemia induced in rabbits by pituitary extract and Fraction HThe Urinary Sediment in Renal Disease 1 February 1961Volume 54, Issue 2Page: 205-214KeywordsBody fluidsCholesterolDentistryExcretionLipidsUrine ePublished: 1 December 2008 Issue Published: 1 February 1961 PDF downloadLoading ...