tbuckley/cabot-search huggingface dataset:
Economic activity and congenital anomalies: an ecologic study in Argentina. ECLAMC ECOTERAT Group.
Authors: E E Castilla, H Campaña, J S Camelo
Journal: Environmental Health Perspectives (2000)

In this study, we analyze the association between industrial activity and the occurrence of 34 congenital anomalies. We selected 21 counties in Argentina during 1982-1994 and examined a total of 614,796 births in these counties in consecutive series. We used the International Standard Industrial Classification of All Economic Activities (United Nations, 1968) as an indicator of exposure to 80 specific industrial activities. Incidence rate ratios for each congenital anomaly were adjusted by the socioeconomic level of the county according to a census index of social deprivation. For a given exposure/anomaly association to be considered as significant and relevant, the exposure had to be a statistically significant risk for the occurrence of the anomaly and an increase in the birth prevalence rate of the congenital anomaly type involved had to be observed in those counties where the putative causal activity was being performed. Significant associations (p < 0.01) were identified between textile industry and anencephaly, and between the manufacture of engines and turbines and microcephaly. These observations are consistent with previous reports on occupational exposure, and their further investigation by means of case-control studies is recommended.
An imprinted QTL with major effect on muscle mass and fat deposition maps to the IGF2 locus in pigs
Authors: Carine Nezer, Laurence Moreau, Benoît Brouwers, Wouter Coppieters, Johann Detilleux, Roger Hanset, Latifa Karim, Alex Kvasz, Pascal Leroy, Michel Georges
Journal: Nature Genetics (1999)
Detection of JAK2 V617F mutation in patients with myeloproliferative disorders using real-time PCR
Authors: Chantal Courtemanche, Richard LeBlanc, Lise Gosselin, Marie-Guylaine Gagnon, Luc Belanger
Journal: Clinical Cancer Research (2006)

A41  Our molecular diagnostic laboratory is using real-time PCR and conventional PCR to identify 25 translocations and mutations associated with sarcomas, leukemias, and lymphomas. Recently, a somatic point mutation in the Janus kinase 2 (JAK2) gene has been identified in patients with BCR/ABL-negative myeloproliferative disorders (MPD) in most cases of polycythemia vera and in a subset of patients with essential thrombocythemia. To detect the JAK2 V617F mutation in MPD patients, we have developed a fast real-time PCR assay that does not require subsequent sequencing. DNA is purified from whole blood and/or bone marrow, PCR is performed on a LightCycler instrument using hybridization probes, and genotype is identified from the melting curve analysis. In addition to being highly specific, melting curve analysis using hybridization probes allows to semi-quantify JAK2 V617F and wild-type alleles. In our cohort of MPD patients, we have identified 26% homozygous and 40% heterozygous for the JAK2 V167F mutation. The proportion of mutant allele varies from 10% to 70% in heterozygous. Although JAK2 V617F mutation has been associated mostly with BCR/ABL-negative MPD, we have identified a patient carrying both the JAK2 V617F mutation (60% of mutant allele) and the BCR-ABL b3;2a translocation associated with chronic myelogenous leukemia (ratio BCR/ABL over G6PDH of 9%). BCR/ABL-negative MPD patients can undergo complete remission after bone marrow transplantation; future work will then study if reappearance of JAK2 V617F mutation in some patients correlate with disease relapse and how JAK2 V617F allele proportion correlate with disease progression. In conclusion, we demonstrated that the JAK2 V617F mutation can be detected by a fast, specific, and semi-quantitative assay based on real-time PCR. This assay simplifies the diagnostic of MDP, especially of polycythemia vera, and could potentially be used to monitor response to therapy.
Current Trends in the Management of Breast Cancer.
Authors: R. Robinson Baker
Journal: Annals of Internal Medicine (1977)

are devoted to the coronary circulation and ischaemic heart disease, the author's own interests being represented here by numerous microangiographs.For more senior pathologists and clinicians the main value of such an atlas is likely to be for the illustrations of conditions they rarely see in the flesh and for teaching.This volume fulfils its planned purpose as a visual aid in cardiac pathology ad- mirably and by present standards it is not expensive.For anyone who has to teach on this subject it is a strongly recommended supplement to their refer- ence books and at this price it should also appeal to any pathologist with an interest in colour photography.
Impact on survival of high-dose therapy with autologous stem cell support in patients younger than 60 years with newly diagnosed multiple myeloma: a population-based study
Authors: Stig Lenhoff, Martin Hjorth, Erik Holmberg, Ingemar Turesson, Jan Westin, Johan Lanng Nielsen, Finn Wislöff, Lorentz Brinch, Kristina Carlson, Margaretha Carlsson, Inger-Marie Dahl, Peter Gimsing, Erik Hippe, Hans E. Johnsen, Jon Lamvik, Eva Löfvenberg, Ingerid Nesthus, Stig Rödjer
Journal: Blood (2000)
A Handbook of Diseases of the Nose and Pharynx.
Authors: James Barry Ball
Journal: JAMA (1902)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Abstract 3498: The Association of Breastfeeding in Infancy and Adult Cardiovascular Disease Risk Factors: The Framingham Third Generation Cohort
Authors: Nisha I Parikh, Shih-Jen Hwang, Erik Ingelsson, Emelia J Benjamin, Caroline S Fox, Ramachandran S Vasan, Joanne M Murabito
Journal: Circulation (2007)

Background: Public health recommendations advocate breastfeeding in infancy as a means to reducing later-life obesity. However many prior studies relating breastfeeding to cardiovascular (CVD) risk factors have been limited by lack of adjustment for maternal and participant confounding factors. Methods: In 962 Framingham Third Generation participants (mean age = 41 yrs, 54% women) we related history of breastfeeding (yes vs. no) and CVD risk factors in young-mid adulthood. Breastfeeding data was ascertained via questionnaire from mothers enrolled in the Framingham Offspring Study. Dependent variables were body mass index (BMI), HDL-cholesterol (HDL-c), total cholesterol, triglycerides, fasting blood glucose, C-reactive protein (CRP), systolic (SBP) and diastolic blood pressure (DBP). Covariates for multivariable adjustment were age, sex, hypertension medications, lipid treatment, smoking, birth order, oral contraceptives, hormone replacement, physical activity, education, maternal smoking, maternal education, and maternal BMI. Low HDL was defined as &lt; 50 mg/dL (women) and &lt; 40 mg/dL(men). Adiposity categories were defined by BMI normal [&lt; 25], overweight [≥ 25 to &lt; 30] and obese [≥ 30 kg/m 2 ]. Generalized estimating equations (GEE) were used to account for sibling correlations. Results: Overall 26% of participants were reported by their mother to have been breastfed. Compared to non-breastfed individuals, breastfed offspring had lower adult BMI [adjusted mean 26.1 kg/m 2 vs. 26.9 kg/m 2 , p = 0.04) and higher adult HDL-c levels [adjusted mean HDL 56.6 mg/dL relative to 53.7 mg/dL p = 0.01] in multivariable-adjusted models. Breastfeeding was not associated with other examined adult CVD risk factors. Upon adjustment for BMI the association between breastfeeding and HDL was attenuated (p = 0.09). Breastfeeding was associated with high versus low HDL (multivariable-adjusted OR = 1.55, p = 0.04) but not with overweight or obesity versus normal weight (p = 0.26, 0.13 respectively). Conclusions: Breastfeeding in infancy is inversely associated with adult BMI and positively associated with HDL-c. Associations between breastfeeding and BMI appear to mediate most of the association with HDL-c.
New Anthrax Treatment Approved
Authors: Rita Rubin
Journal: JAMA (2015)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
1002. Immune Responses to AAV and to Factor IX in a Phase I Study of AAV-Mediated, Liver-Directed Gene Transfer for Hemophilia B
Authors: Katherine High, Catherine Manno, Denise Sabatino, Sylvia Hutchison, Michael Dake, Mahmood Razavi, Robin Kaye, Valder Aruda, Roland Herzog, Pradip Rustagi, John Rasko, Keith Hoots, Phillip Blatt, Jurg Sommer, Margaret Ragni, Margareth Ozelo, Barbara Konkle, Ruth Lessard, Alvin Luk, Bertil Glader, Glenn Pierce, Linda Couto, Mark Kay
Journal: Molecular Therapy (2004)
Abstract 1543: Systematic functional assessment of driver mutations for individual ovarian cancers
Authors: Seiichi Mori, Takako Yokomizo, Takeshi Fujiwara, Osamu Goto, Haruko Iwase, Kazuyoshi Kato, Tokuichi Kawaguchi, Tetsuo Noda
Journal: Cancer Research (2014)

Abstract Although epithelial ovarian cancer is an intractable cancer and the overall five-year survival rate is approximately 40 to 50%, clinically effective molecular-targeted therapeutics to treat ovarian cancer has not been available thus far. Recent progress of massively parallel sequencing technologies has been enabling us to identify substantial number of genomic aberrations including somatic mutations, indels and translocations in variable cancer types exemplified by epithelial ovarian cancer and non-small cell lung cancer. However, it is still very difficult to identify a ‘driver’ gene, which is functionally relevant for cancer growth, from hundreds of mutations that are usually found from a single cancer sample of an individual patient. An in vitro cultured cell line, which is originated from a clinical sample, can be utilized to assess functions of the genes that are identified to have somatic aberrations in the paired clinical tumor. We have been establishing multiple ovarian cancer cell lines derived from clinical samples and analyzing pairs of the cell lines and clinical samples with exon-capture sequencing. The genes, which are somatically mutated and shared in a pair of cell line and clinical sample, are targeted with RNA interference in the cell line, and subsequently the effect on cell proliferation and survival is examined. As such, a driver mutation for an individual cancer can be identified by a set of experimental perturbations. Identified driver mutations would be then validated with publicly available databases and with clinical archive samples. As a proof-of-principle, somatic mutations of PIK3CA and KRAS were detected as drivers to promote cell proliferation of a carcinosarcoma. We believe this approach can increase an opportunity to identify molecular targets in ovarian cancer therapeutics. Citation Format: Seiichi Mori, Takako Yokomizo, Takeshi Fujiwara, Osamu Goto, Haruko Iwase, Kazuyoshi Kato, Tokuichi Kawaguchi, Tetsuo Noda. Systematic functional assessment of driver mutations for individual ovarian cancers. [abstract]. In: Proceedings of the 105th Annual Meeting of the American Association for Cancer Research; 2014 Apr 5-9; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2014;74(19 Suppl):Abstract nr 1543. doi:10.1158/1538-7445.AM2014-1543
Conversion of tumor-specific CD4+ T-cell tolerance to T-cell priming through in vivo ligation of CD40
Authors: Eduardo M. Sotomayor, Ivan Borrello, Erev Tubb, Frédérique-Marie Rattis, Harold Bien, Zhengbin Lu, Steve Fein, Stephen Schoenberger, Hyam I. Levitsky
Journal: Nature Medicine (1999)
Stents Wrapped in Autologous Vein: An Experimental Study11This investigation was supported by a grant from the Hellenic Heart Foundation, Athens, Greece.
Authors: CHRISTODOULOS STEFANADIS, KONSTANTINOS TOUTOUZAS, CHARALAMBOS VLACHOPOULOS, COSTAS STRATOS, IOANNIS KALLIKAZAROS, PANAYIOTIS KARAYANNAKOS, PAVLOS TOUTOUZAS, MICHAEL M. GRAVANIS, KEITH ROBINSON
Journal: Journal of the American College of Cardiology (1996)
Summary of the Informal Discussion of Dietary Factors and Hormone-dependent Cancers
Authors: Arthur I. Holleb
Journal: Cancer Research (1975)

Dr. de Waard wasaskedabout variablesassociatedwith height and 1st pregnancy. The 2nd point raised was in regard to the cumulative percentageof 1st preganciesin Holland and in Japan. It was suggested that one should go back about 30 or 40 years since it seemed that at that time the age of 1st pregnancy in Holland and Japan varied. Dr. de Waard responded that the relationship among weight, height, and menarche is complex and neededsorting out in terms of mechanisms and the relationship that exists among them. He noted that his data are fairly recent and cross-sectional and that it might be helpful to have historical data as well. One participant reported that in 524 cases of breast cancer in a white population in New York he had found no relationship to height or weight and that this may be due to a population difference in America and the Netherlands. Furthermore, the height and weight data could not explain in the United Statesa higher rate amongJewsand a lower rate among blacks. Also one can selectdata easily as shown by the fact that women with endometrial cancer are significantly heavier than controls. It was reported that young women in the United States are taller than older women and that younger women have menstruated earlier than the older women. There is a
Abstract 2566: Activation of tumor-initiated T cell priming and tumor destruction with potent STING-activating cyclic dinucleotide derivatives
Authors: Laura Hix Glickman, David B. Kanne, Sarah M. McWhirter, Meredith L. Leong, Edward E. Lemmens, Ken Metchette, Russell E. Vance, Drew M. Pardoll, Thomas W. Dubensky
Journal: Cancer Research (2014)

Abstract Cyclic dinucleotides (CDNs) are bacterial messengers that are sensed by the host cytosolic surveillance pathway receptor, STING (Stimulator of Interferon Genes). CDN binding to STING initiates a TLR-independent signaling cascade through the TBK-1/IRF-3 axis, inducing type I interferon (IFN) and other co-regulated genes central to host innate defense. In response to binding cytosolic double-stranded DNA, a recently discovered mammalian enzyme, cyclic GMP-AMP synthase (cGAS), synthesizes CDNs that are structurally distinct from CDNs produced by bacteria. The mammalian CDN has a phosphate bridge with 2′-5′ and 3′-5′ linkages that increases its affinity for STING at least 10-fold. We show that mixed linkage (ML) CDNs were more potent activators of human PBMCs as compared to CDNs with canonical 3′-5′ phosphate linkages. Additionally, particular ML CDN derivatives with sulfur atoms at non-bridging oxygens of the internucleotide phosphate bridge were resistant to digestion by host cell phosphodiesterases, and R,R di-thio CDN diastereomers demonstrated increased potency in vitro and in vivo, as compared to either the R,S di-thio CDN diastereomer, or unmodified CDNs. Strikingly, direct injection of 2-week established flank B16 melanoma tumors with ML R,R dithio-CDN derivatives significantly and profoundly inhibited tumor growth, correlated with cytokine-mediated activation of NK and T lymphocytes, induction of antigen-specific T cell immunity and long-term survival. Anti-tumor efficacy was lost in mice encoding non-functional STING. Similar results were observed in other tumor models. These results demonstrate that CDNs have high translation potential for treatment strategies to induce activation of the tumor microenvironment, leading to effective tumor-initiated CD8+ T cell priming and anti-tumor efficacy. Citation Format: Laura Hix Glickman, David B. Kanne, Sarah M. McWhirter, Meredith L. Leong, Edward E. Lemmens, Ken Metchette, Russell E. Vance, Drew M. Pardoll, Thomas W. Dubensky. Activation of tumor-initiated T cell priming and tumor destruction with potent STING-activating cyclic dinucleotide derivatives. [abstract]. In: Proceedings of the 105th Annual Meeting of the American Association for Cancer Research; 2014 Apr 5-9; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2014;74(19 Suppl):Abstract nr 2566. doi:10.1158/1538-7445.AM2014-2566
Abstract 24: From JNC 1 to JNC 8: Population Impact and Cost-Effectiveness of U.S. Hypertension Guidelines
Authors: Nathalie Moise, Keane Tzong, Lee Goldman, Pamela Coxson, Kirsten Bibbins-Domingo, Andrew Moran
Journal: Circulation (2015)

The 2014 “JNC 8” hypertension guideline decreased the population eligible for treatment and altered blood pressure (BP) targets. We aimed to assess the public health impact and cost-effectiveness of implementing JNC 8 recommendations in the context of prior JNC guidelines. Methods: Using the Cardiovascular Disease (CVD) Policy Model, we simulated CVD events and non-CVD deaths prevented, quality-adjusted life years (QALYs) gained, drug and monitoring costs incurred, and CVD treatment costs averted, if each JNC guideline were fully implemented in a population of untreated U.S. adults aged 35-74 years between 2014-2024. Incremental cost effectiveness ratios (ICER) were calculated as change in costs divided by change in QALYs. An ICER of <50,000 was considered cost effective. JNC guidelines were simplified into four periods based on treatment targets: JNC 1-3 (DBP <90 mmHg), JNC 4 (DBP < 90mmHg or isolated SBP <160mmHg), JNC 5-7 [<130/80 mmHg for diabetes and/or chronic kidney disease (CKD); BP <140/90 mmHg f...
Rationale and study design of the <scp>NEuroCardiac TherApy foR</scp> Heart Failure Study: <scp>NECTAR‐HF</scp>
Authors: Gaetano M. De Ferrari, Anton E. Tuinenburg, Stephen Ruble, Josep Brugada, Helmut Klein, Christian Butter, David J. Wright, Bernd Schubert, Scott Solomon, Scott Meyer, Kenneth Stein, Agnes Ramuzat, Faiez Zannad
Journal: European Journal of Heart Failure (2014)
What is specific about category specificity? Fractionating patterns of impairments and the spurious living/nonliving dichotomy
Authors: E. C. Leek, E. M. Pothos
Journal: Behavioral and Brain Sciences (2001)

What aspects of the data from studies of acquired category- specific impairments are relevant to theories of knowledge representation? Discussion in the target article focuses on the living/nonliving dichotomy. However, many case studies reveal considerably more complex patterns of impaired and preserved performance that undermine this distinction. We consider this evidence and discuss its implications for theories of knowledge representation.
A TEST FOR THE MORE ACCURATE RECOGNITION OF GALL-BLADDER AND LIVER BILE DURING DIAGNOSTIC BILIARY DRAINAGE
Authors: Augustus A. Hall, John M. Masen
Journal: Annals of Internal Medicine (1951)

Article1 October 1951A TEST FOR THE MORE ACCURATE RECOGNITION OF GALL-BLADDER AND LIVER BILE DURING DIAGNOSTIC BILIARY DRAINAGEAUGUSTUS A. HALL, JOHN M. MASENAUGUSTUS A. HALLSearch for more papers by this author, JOHN M. MASENSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-35-4-812 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptINTRODUCTIONThe gross interpretation of gall-bladder bile and liver bile during diagnostic biliary drainage is basically important in the evaluation of the fluid obtained. The sequence of bile flow in a normal subject, as first emphasized by Lyon,1is a small amount of "A," or common duct bile, usually lemon to golden yellow in color. The next bile to appear is the "B" or gall-bladder bile, yellow brown in color. Last in the sequence is the "C," or liver bile, normally a golden yellow in color. Many deviations from this normal color sequence occur in disease and/or pathologic physiologic aberrations...Bibliography1. Lyon BB: Non-surgical drainage of the gall-tract, 1923, Lea and Febiger, Philadelphia and New York. Google Scholar2. Lyon BB: The cyclopedia of medicine, surgery and specialties, 1939, F. A. Davis Co., Philadelphia, pp. 165-185. Google Scholar3. CounsellerMcIndoe VSAH: Dilatation of bile ducts (hydrohepatosis), Surg., Gynec. and Obst. 43: 729, 1926. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: *Received for publication August 14, 1950.From the Brooke General Hospital, Fort Sam Houston, Texas. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byBiliary Tract StudiesBeobachtungen zu Krankheitsbild, Pathogenese und �tiologie der akuten erworbenen h�molytischen An�mie (Lederer-An�mie) 1 October 1951Volume 35, Issue 4Page: 812-819KeywordsBileLiver ePublished: 1 December 2008 Issue Published: 1 October 1951 PDF downloadLoading ...