tbuckley/cabot-search huggingface dataset:
Comparison of Outcomes in Adults With Pediatric‐Onset Morphea and Those With Adult‐Onset Morphea: A Cross‐Sectional Study From the Morphea in Adults and Children Cohort
Authors: Daniel Condie, Daniel Grabell, Heidi Jacobe
Journal: Arthritis & Rheumatology (2014)

Objective Few studies have examined outcomes in adults with pediatric‐onset morphea. The objective of the present study was to compare clinical outcomes and health‐related quality of life (HRQOL) in adults with onset of morphea in childhood to those in patients with adult onset of morphea. Methods Participants in the study were drawn from the Morphea in Adults and Children cohort and included 68 adults with pediatric‐onset morphea and 234 patients with adult‐onset morphea. Outcome measures included the Localized Scleroderma Cutaneous Assessment Tool (LoSCAT), physical examination findings, and HRQOL questionnaires. Results Adults with pediatric‐onset morphea were younger, had longer disease duration, and were more likely to have the linear subtype of morphea. Patients with pediatric‐onset disease were less likely to have active disease. Among patients with active disease, those with pediatric‐onset morphea had less disease activity as measured by the LoSCAT. Patients with pediatric‐onset disease had higher severity of disease damage when measured by the physician's global assessment of damage, but had similar levels of disease damage when measured by the Localized Scleroderma Skin Damage Index. Patients with pediatric‐onset disease had more favorable HRQOL scores for all measures, all of which were statistically significantly different from those in patients with adult‐onset morphea. Conclusion Adults with pediatric‐onset morphea differ from patients with adult‐onset disease with respect to disease subtype, severity of disease activity and damage, and levels of HRQOL.
Sézary syndrome without erythroderma
Authors: Aurélia Henn, Laurence Michel, Charlotte Fite, Lydia Deschamps, Nicolas Ortonne, Saskia Ingen-Housz-Oro, Eduardo Marinho, Marie Beylot-Barry, Martine Bagot, Liliane Laroche, Béatrice Crickx, Eve Maubec
Journal: Journal of the American Academy of Dermatology (2015)
LSC 2012 abstract - Monocyte-derived dendritic cell recruitment and allergic TH2 responses after exposure to diesel particles are CCR2-dependent
Authors: Tania Maes, Sharen Provoost, Guy Joos, Kurt Tournoy
Journal: European Respiratory Journal (2012)

Background: Diesel exhaust particles (DEP) inhalation is associated with increased sensitization towards inhaled allergens. Inhalation of DEP increases pulmonary dendritic cell (DC) accumulation and enhances TH2 responses in mediastinal lymph nodes 1 . In inflammatory conditions, DC recruitment is mediated by different CC chemokine receptors (CCR). We hypothesized that CCR2 mediates DC recruitment and TH2 responses upon DEP exposure.  Methods and Results: WT and CCR2 KO mice were exposed to saline or DEP, followed by immunological examination. DEP-exposure increased pulmonary expression of CCR2 and MCP-1 in WT mice. DEP-exposure induced a pulmonary recruitment of monocytes and inflammatory (CD11b+) DCs in WT mice, which was abolished in CCR2 KO mice. Adoptive transfer of fluorescently labeled bone marrow derived cells from WT and CCR2 KO mice into DEP-exposed WT mice demonstrated the direct involvement of CCR2 in recruitment of blood monocytes towards the lung upon DEP-exposure. Furthermore, analysis of TH2 cytokine production in mediastinal lymph nodes upon DEP-exposure showed an abolished TH2 response in CCR2 KO mice.  Conclusion: These data suggest that monocyte-derived DC, recruited in a CCR2-dependent manner, are critical in inducing TH2 responses upon DEP inhalation.  Funding: Belgian IUAP (P6/35), FWO-Flanders (G.0052.06; G.0329.11N).   1 Provoost et al, J. Immunol 2010, 184:426-32.
Effects of cis-Dichlorodiammine Platinum (II) in the Regression of Sarcoma 180: A Fine Structural Study.2
Authors: Ajit Sodhi, Surinder K. Aggarwal
Journal: JNCI Journal of the National Cancer Institute (1974)

Journal Article Effects of cis-Dichlorodiammine Platinum (II) in the Regression of Sarcoma 180: A Fine Structural Study. Get access Ajit Sodhi, Ajit Sodhi Search for other works by this author on: Oxford Academic PubMed Google Scholar Surinder K. Aggarwal Surinder K. Aggarwal 4Department of Zoology, Michigan State University, East Lansing, Mich. 48823. Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 53, Issue 1, July 1974, Pages 85–101, https://doi.org/10.1093/jnci/53.1.85 Published: 01 July 1974 Article history Received: 20 February 1973 Revision received: 19 February 1974 Accepted: 28 March 1974 Published: 01 July 1974
Early oxygen desaturation is related to AMS development during acute exposure to high altitude (HA)
Authors: Luca Pomidori, Gaia Mandolesi, Giovanni Avancini, Eva Bernardi, Annalisa Cogo
Journal: European Respiratory Journal (2011)

Early desaturation during acute simulated HA exposure is significantly related to AMS development.

Aim: To study the hypoxic profile and the AMS development during the ascent from Alagna (A), 1200m, to Capanna Regina Margherita (M), 4559m, with an overnight stay in Rifugio Gnifetti (G), 3647m.

Methods: 44 (8F) subjects (age 18-67) were recruited in A, equipped with a 24-h data memory pulse oximeter (Pulsox-3Si, Minolta) and asked to fill the Lake Louise questionnaire (LL).

Results: 15 subjects (34%) showed a LL score ≥3 (AMS+). In A SpO2 data were similar but during HA exposure AMS+ group had a significantly lower SpO2: at Punta Indren (I), 3275m after a 45min cable car ascent; in G during 3h rest and the subsequent night. There was no significant difference during the 2h exercise (Ex1) to reach G.

View this table:

Table 1. Spo2% mean





In G, AMS+ always spent more time with a lower SpO2.

View this table:

Table 2. % of total time





As regard the ascent to M (Ex2), data of only 24 subjects are available, (5 AMS+; 19 AMS–). None of AMS- group developed AMS during the climb to M. AMS+ had a significantly lower SpO2 as compared to AMS- but the sample is too small to draw definitive conclusions.

Conclusion: AMS development is significantly related to a more severe O2 desaturation at rest and during the night; the more severe hypoxemia occurs very early at the beginning of HA exposure as already shown during hypoxia simulated test (Loeppky '08 and Burtscher '04) (*p<0,05).
Alterations of Glycolipid Glycosyltransferase Levels in Lymphoma and Lymphoid Tissues of Lymphoma-Bearing Hamsters2
Authors: Teruo Ishibashi, Tomoyoshi Atsuta, Akira Makita
Journal: JNCI Journal of the National Cancer Institute (1975)

Thymuses from lymphoma-bearing hamsters in advanced stages of tumor growth showed enhanced activities of four glycolipid—glycosyltransferases which lead to the step-wise synthesis of lactosylceramide to Forssman hapten. The α-galactosyltransferase activity of the thymus was decreased until day 6 of inoculation but increased thereafter. The activities of all the transferases tested were significantly lowered in lymphoma tissue. The level of UDP-galactose pyrophosphatase did not correlate with the transferase activities.
Qualitative characteristic of clusters of dyspnea in various diseases
Authors: Nina Karoli, Alina Tsybulina
Journal: European Respiratory Journal (2013)

purpose of the research was to revelation of special features of Cluster analysis among the patients with different diseases.  In the research take part 180 people with chronic heart failure - 50; COPD - 43 people, bronchial asthma -50, idiopathic interstitial pneumonia - 26 and 11 people with obesity. In the research was conducted an oral inquiry, qualitative assessment of dyspnea with an adapted survey The indication of shortbreathing » [Simon et al., 1990, Elliott et al., 1991] and 8 clusters of dyspnea (Simon et al., 1990).  Due to the research it was revealed that each group of diseases in the description of shortness of breath is characterized by the various clusters. For the patients with COPD it is typical to have clusters of heaviness, work / effort, shallow breathing and frequency, which are caused by lung hyperinflation, and for the patients with bronchial asthma - suffocation, heaviness and exhalation which are the characteristics of bronchial obstruction, among patients with idiopathic interstitial pneumonia which is a result of the restriction, emerged the clusters shallow breathing, heaviness and exhalation. Patients with chronic heart failure which is a result of an insufficient blood have clusters of dyspnea, clusters are the frequency, choking and work / effort, and patients with obesity have frequency and shallow breathing as a result of poor exercise tolerance.  Due to the research it was revealed that each disease is characterized by certain clusters of dyspnea, and it may be of great importance for diagnosis of diseases and detection of the possible mechanism of dyspnea.
Function of Myocardial Mitochondria in the Adriamycin-Induced Cardiomyopathy of Rabbits2
Authors: Colin C. Bier, Roger S. Jaenke
Journal: JNCI Journal of the National Cancer Institute (1976)

Journal Article Function of Myocardial Mitochondria in the Adriamycin-Induced Cardiomyopathy of Rabbits Get access Colin C. Bier, Colin C. Bier Search for other works by this author on: Oxford Academic PubMed Google Scholar Roger S. Jaenke Roger S. Jaenke 3 3Department of Pathology, College of Veterinary Medicine and Biomedical Sciences, Colorado State University, Fort Collins, Colo. 80523. Address reprint requests to Dr. Jaenke. Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 57, Issue 5, November 1976, Pages 1091–1094, https://doi.org/10.1093/jnci/57.5.1091 Published: 01 November 1976 Article history Received: 10 December 1975 Accepted: 16 April 1976 Published: 01 November 1976
Vitiligo: new insights
Authors: M. Picardo
Journal: British Journal of Dermatology (2012)

Journal Article Vitiligo: new insights Get access M. Picardo M. Picardo San Gallicano Dermatologic Institute, IRCCS, Via Elio Chianesi 53, 00144 Rome, Italy E‐mail: picardo@ifo.it Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 166, Issue 3, 1 March 2012, Pages 472–473, https://doi.org/10.1111/j.1365-2133.2012.10839.x Published: 01 March 2012
Myeloid Cells and Related Chronic Inflammatory Factors as Novel Predictive Markers in Melanoma Treatment with Ipilimumab
Authors: Christoffer Gebhardt, Alexandra Sevko, Huanhuan Jiang, Ramtin Lichtenberger, Maike Reith, Kathrin Tarnanidis, Tim Holland-Letz, Ludmila Umansky, Philipp Beckhove, Antje Sucker, Dirk Schadendorf, Jochen Utikal, Viktor Umansky
Journal: Clinical Cancer Research (2015)

Immunotherapy with ipilimumab improves the survival of patients with metastatic melanoma. Because only around 20% of patients experience long-term benefit, reliable markers are needed to predict a clinical response. Therefore, we sought to determine if some myeloid cells and related inflammatory mediators could serve as predictive factors for the patients' response to ipilimumab.We performed an analysis of myeloid cells in the peripheral blood of 59 stage IV melanoma patients before the treatment and at different time points upon the therapy using a clinical laboratory analysis and multicolor flow cytometry. In addition, the production of related inflammatory factors was evaluated by ELISA or Bio-Plex assays.An early increase in eosinophil count during the treatment with ipilimumab was associated with an improved clinical response. In contrast, elevated amounts of monocytic myeloid-derived suppressor cells (moMDSC), neutrophils, and monocytes were found in nonresponders (n = 36) as compared with basal levels and with responding patients (n = 23). Moreover, in nonresponders, moMDSCs produced significantly more nitric oxide, and granulocytic MDSCs expressed higher levels of PD-L1 than these parameters at baseline and in responders, suggesting their enhanced immunosuppressive capacity. Upon the first ipilimumab infusion, nonresponders displayed elevated serum concentrations of S100A8/A9 and HMGB1 that attract and activate MDSCs.These findings highlight additional mechanisms of ipilimumab effects and suggest levels of eosinophils, MDSCs, as well as related inflammatory factors S100A8/A9 and HMGB1 as novel complex predictive markers for patients who may benefit from the ipilimumab therapy. Clin Cancer Res; 21(24); 5453-9. ©2015 AACR.
The expanding role of primary care in cancer control
Authors: Greg Rubin, Annette Berendsen, S Michael Crawford, Rachel Dommett, Craig Earle, Jon Emery, Tom Fahey, Luigi Grassi, Eva Grunfeld, Sumit Gupta, Willie Hamilton, Sara Hiom, David Hunter, Georgios Lyratzopoulos, Una Macleod, Robert Mason, Geoffrey Mitchell, Richard D Neal, Michael Peake, Martin Roland, Bohumil Seifert, Jeff Sisler, Jonathan Sussman, Stephen Taplin, Peter Vedsted, Teja Voruganti, Fiona Walter, Jane Wardle, Eila Watson, David Weller, Richard Wender, Jeremy Whelan, James Whitlock, Clare Wilkinson, Niek de Wit, Camilla Zimmermann
Journal: The Lancet Oncology (2015)
Effect of low level laser (LLL) and mesenchymal stem cells (htMSCs) therapies on cigarette-induced lung inflammation in mice
Authors: Jean Pierre Peron, Vanessa da Silva, Manoel de Oliveira, Tatiana Jazedje, Mayra Pelatti, Carlos Eduardo Czeresnia, Paulo Perin, Marcelo Gil Nisenbauum, Lucila Evangelista, Silvio Halpern, Mariângela Maluf, Mayana Zatz, Ana Paula Ligeiro de Oliveira
Journal: European Respiratory Journal (2013)

Chronic Obstructive Pulmonary Disease (COPD) has a high prevalence and economic and social cost. In this context, new therapeutic approaches such as the use of Mesenchymal Stem Cells (MSCs) or low level laser therapy (LLL) may be innovative and promising. Here we investigated the effect of LLL (670 nm) and htMSCs (human tubal-derived Mesenchymal Stem Cells) for the treatment of cigarette-induced pulmonary inflammation in mice. To induce COPD C57Bl/6 mice were submitted to cigarette smoke for 75 days (2 times/day). Next, animals were treated with LLL (COPD+LLL group) or htMSCs (COPD+htMSCs group) 7 and 15 days before the experiment, on day 76th when mice were sacrified for morphologic and functional analysis of the lung. Bronchoalveolar lavage (BAL) analysis showed that COPD+LLL and COPD+htMSCs groups had a significant decrease in neutrophils and lymphocytes when compared to COPD group. This was associated with reduced mucous secretion and collagen deposition. Moreover, LLL significantly reduced IL-6 and TNF-α, which was not observed after htMSCs. In vitro experiments showed reduction in IL-6 secretion by bronchial epithelial cells (BEC) and TNF-α by pneumocytes type II (PII) exposed to cigarette extract at 2,5% and further irradiated with LLL. These results indicate that LLL and htMSCs therapies have anti-inflammatory effect on cigarette-induced lung inflammation reducing local inflammation and may be considered interesting therapeutic approaches.  Support Financial: UNINOVE, FAPESP-CEPID, INCT,CNPq.
The impact of breast-conserving treatment and mastectomy on the quality of life of early-stage breast cancer patients: a review.
Authors: G M Kiebert, J C de Haes, C J van de Velde
Journal: Journal of Clinical Oncology (1991)

In recent years, doubt has been shed on the necessity of mastectomy for women with early-stage breast cancer. Apart from purely medical studies comparing (radical) mastectomy to less intruding surgical treatment, a number of studies (N = 18) have been published investigating the impact of breast-conserving treatment versus mastectomy on quality of life. We review these studies with respect to medical issues (treatment modality, stage of disease), methodologic issues (design, measurement moment, sample size), and results (psychologic discomfort, changes in life patterns, fears and concerns). It is concluded that there is no solid proof of a better psychologic adjustment after breast-conserving treatment and that there are no substantial differences between the different treatment modalities in changes of life patterns and fears and concerns. However, the results with respect to body image and sexual functioning favor the use of breast-conserving treatment.
On the use of nucleic acid sequences to infer early branchings in the tree of life.
Authors: Z Yang, D Roberts
Journal: Molecular Biology and Evolution (1995)

Simplifying assumptions made in various tree reconstruction methods--notably rate constancy among nucleotide sites, homogeneity, and stationarity of the substitutional processes--are clearly violated when nucleotide sequences are used to infer distant relationships. Use of tree reconstruction methods based on such oversimplified assumptions can lead to misleading results, as pointed out by previous authors. In this paper, we made use of a (discretized) gamma distribution to account for variable rates of substitution among sites and built models that allowed for unequal base frequencies in different sequences. The models were nonhomogeneous Markov-process models, assuming different patterns of substitution in different parts of the tree. Data of the small-subunit rRNAs from four species were analyzed, where base frequencies were quite different among sequences and rates of substitution were highly variable at sites. Parameters in the models were estimated by maximum likelihood, and models were compared by the likelihood-ratio test. The nonhomogeneous models provided significantly better fit to the data than homogeneous models despite their involvement of many parameters. They also appeared to produce reasonable estimation of the phylogenetic tree; in particular, they seemed able to identify the root of the tree.
Interferon-alpha, zidovudine, and granulocyte-macrophage colony-stimulating factor: a phase I AIDS Clinical Trials Group study in patients with Kaposi's sarcoma associated with AIDS.
Authors: S E Krown, J Paredes, D Bundow, B Polsky, J W Gold, N Flomenberg
Journal: Journal of Clinical Oncology (1992)

PURPOSE To increase the hematologic tolerance of interferon-alpha (IFN alpha) and zidovudine combination therapy by the addition of granulocyte-macrophage colony-stimulating factor (GM-CSF), and to evaluate the safety, tolerance, and potential efficacy of the combination in patients with Kaposi's sarcoma and AIDS. PATIENTS AND METHODS Seventeen patients with Kaposi's sarcoma associated with AIDS received zidovudine 200 mg orally every 4 hours and GM-CSF 5 micrograms/kg/d subcutaneously. Successive cohorts received IFN-alpha 2b at a daily subcutaneous dose of 5, 10, or 20 million units. The dose of GM-CSF was titrated to maintain the neutrophil count between 1 and 5 x 10(9) cells/L. Doses of all three drugs were reduced, as required, for nonhematologic toxicities. RESULTS GM-CSF induced leukocytosis in all patients. On average, a dose of 1.25 micrograms/kg/d was sufficient to maintain the neutrophil count within the desired range. The combination of 20 million units of IFN-alpha with zidovudine and GM-CSF induced dose-limiting toxicity in four of six patients. The major side effects were constitutional symptoms, which included malaise, anorexia, fatigue, fever, and were dose-limiting in three patients. Severe anemia and/or thrombocytopenia developed in three patients. Seven patients (41%; 95% confidence interval [CI], 18% to 64%) showed objective tumor regression that persisted for a median of 51 weeks. A rapid decrease in free-serum p24 antigen levels was observed in seven patients who had measurable levels at baseline; the mean time required to isolate human immunodeficiency virus (HIV-1) from peripheral-blood cells was increased by 7 days. The number and percentage of CD4-positive lymphocytes showed no significant change. CONCLUSIONS GM-CSF prevents neutropenia induced by the IFN-alpha and zidovudine combination and induced no adverse effects on immune function or HIV activity. However, nonhematologic toxicity precluded a major increase in the maximum-tolerated doses of IFN-alpha and zidovudine.
Collecting Duct Na+/K+-ATPase Activity Is Correlated with Urinary Sodium Excretion in Rat Nephrotic Syndromes
Authors: GEORGES DESCHE[Combining Circumflex Accent]NES, ALAIN DOUCET
Journal: Journal of the American Society of Nephrology (2000)

Abstract. In puromycin aminonucleoside (PAN)-treated nephrotic rats, sodium retention is associated with increased Na + /K + -ATPase activity in the cortical collecting ducts (CCD). This study was undertaken to determine whether stimulation of Na + /K + -ATPase in the CCD is a feature of other experimental nephrotic syndromes, whether it might be responsible for renal sodium retention, and whether it is mediated by increased plasma vasopressin levels or activation of calcineurin. For this purpose, the time courses of urinary excretion of sodium and protein, sodium balance, ascites, and Na + /K + -ATPase activities in microdissected CCD were studied in rats with PAN or adriamycin nephrosis or HgCl 2 nephropathy. The role of vasopressin and calcineurin in PAN nephrosis were evaluated by measuring these parameters in Brattleboro rats and in rats treated with cyclosporin or tacrolimus. Despite different patterns of changes in urinary sodium and protein excretion in the three nephrotic syndrome models, there was a linear relationship between CCD Na + /K + -ATPase activities and sodium excretion in all three cases. The results also indicated that there was no correlation between proteinuria and sodium retention, but ascites was present only when proteinuria was associated with marked reduction of sodium excretion. Finally, the lack of vasopressin in Brattleboro rats or the inhibition of calcineurin by administration of either cyclosporin or tacrolimus did not prevent development of the nephrotic syndrome in PAN-treated rats or stimulation of CCD Na + /K + -ATPase. It is concluded that stimulation of Na + /K + -ATPase in the CCD of nephrotic rats might be responsible for sodium retention and that this phenomenon is independent of proteinuria and vasopressin and calcineurin activities.
Clinical relevance of CD44 cell-surface expression and N-myc gene amplification in a multicentric analysis of 121 pediatric neuroblastomas.
Authors: V Combaret, N Gross, C Lasset, D Frappaz, G Peruisseau, T Philip, D Beck, M C Favrot
Journal: Journal of Clinical Oncology (1996)

PURPOSE In contrast to other human tumors, a repression of the cell-surface glycoprotein CD44 on neuroblastoma is a marker of aggressiveness that usually correlates to N-myc amplification. We thus compared the prognostic value of both markers in the initial staging of 121 children treated for neuroblastoma in collaborative institutions. METHODS Frozen samples were analyzed by a rapid and well-standardized technique of immunostaining with monoclonal antibodies (MoAbs) against epitopes in the CD44 constant region. RESULTS In this retrospective series, CD44 was expressed on 102 specimens and strongly correlated with favorable tumor stages and histology, younger age, and normal N-myc copy numbers. In univariate analysis, CD44 expression and normal N-myc were the most powerful markers of favorable clinical outcome (P &lt; 10(-6) and chi 2 = 65.40 and P &lt; 10(-6) and chi 2 = 42.56, respectively), but analysis of CD44 affords significant prognostic discrimination in subgroups of patients with or without N-myc-amplified tumors. In the subgroup of stage IV neuroblastomas, CD44 was the only significant prognostic marker (P &lt; .02, chi 2 = 5.76), whereas N-myc status was not discriminant. In multivariate analysis of five factors, ie, N-myc amplification, CD44 expression, age, tumor stage, and histology, the only independent prognostic factors of event-free survival were CD44 expression and tumor stage. CONCLUSION The analysis of CD44 cell-surface expression must be recommended as an additional biologic marker in the initial staging of the disease.