SODIUM SUCCINATE—AN ANALEPTIC FOR BARBITURATE POISONING IN MAN
Authors: R H BARRETT
Journal: Annals of Internal Medicine (1949)

Article1 November 1949SODIUM SUCCINATE—AN ANALEPTIC FOR BARBITURATE POISONING IN MANRICHARD H. BARRETT, M.D., M.SC.RICHARD H. BARRETT, M.D., M.SC.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-31-5-739 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe barbiturates, next to carbon monoxide, are the most frequent source of poisoning, both suicidal and accidental.2 This may well be attributable to the widespread use of the barbiturate drugs1 as evidenced by the fact that in 1945, alone, over 290 tons of this one group of hypnotics were produced.This paper reports an investigation of the effects of a new analeptic agent, sodium succinate, in the treatment of poisoning with barbituric acid compounds.The present and generally accepted treatment of barbiturate poisoning3consists of one or all of the following procedures with, possibly, others: (a) Administration of oxygen, alone...Bibliography1. Federal officials puzzled by large United States consumption of sleeping pills, Jr. Am. Med. Assoc., 1946, cxxxiii, 405. Google Scholar2. . Conferences on Therapy; Treatment of Barbiturate Poisoning, Am. Jr. Med., 1946, i, 93-103. Google Scholar3. BARRETT RH: The analeptic effect of sodium succinate on barbiturate depression in man, Anesthesia and Analgesia, 1947, xxvi, 74-81, 105-113. Google Scholar4. DARCEY JF: The picrotoxin treatment of barbiturate poisoning, Jr. Nerv. and Ment. Dis., 1944, xcix, 367-375. Google Scholar5. BARLOW OW: The relative efficiency of a series of analeptics as antidotes to sublethal and lethal dosages of pentobarbital, chloral hydrate, and tribromethanol ("Avertin"), Jr. Pharmacol. and Exper. Therap., 1935, lv, 1-22. Google Scholar6. SOSKINTAUBENHAUS SM: Sodium succinate as an analeptic for barbiturate poisoning and in the control of the duration of barbiturate anesthesia, Jr. Pharmacol. and Exper. Therap., 1943, lxxviii, 49-55. Google Scholar7. CAMPBELLMAESBARRETT CJJPRH: Sodium succinate as an analeptic in man, Fed. Proc., 1946, v, 15. Google Scholar8. FITCHTATUM RHAL: Duration of action of barbituric acid hypnotics as a basis of classification, Jr. Pharmacol. and Exper. Therap., 1932, xliv, 325-335. Google Scholar9. RICHARDS RK: The therapy of barbiturate poisoning, In: FANTUS, BERNARD: The therapy of the Cook County Hospital, Jr. Am. Med. Assoc., 1940, cxv, 527-529. Google Scholar10. ELLIOTT KA: The possible rôle of intermediary metabolites as hydrogen carriers. In: A symposium on respiratory enzymes, 1942, The University of Wisconsin Press, Madison, pp. 33-35. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Hanover, New Hampshire*Presented at New England Sectional Meeting of the American College of Physicians, January 28, 1947.From the Hitchcock Clinic, Mary Hitchcock Memorial Hospital, Hanover, New Hampshire. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited bySudden Death after the Administration of Sodium SuccinateREMARQUES SUR LE TRAITEMENT DE LA SCLÉROSE EN PLAQUES PAR LE SUCCINATE SODIQUEAn appraisal of the present treatment of barbiturateElectrographic monitoring of anaesthesia*THE ANALEPTIC EFFECT OF SUCCINATE IN COMA AND IN CONFUSIONAL STATESThe Pathologic Physiology of Cerebral Metabolic Disease 1 November 1949Volume 31, Issue 5Page: 739-749KeywordsCarbon monoxideDrugsHospitalsOxygenSodium Issue Published: 1 November 1949 PDF downloadLoading ...