tbuckley/cabot-search huggingface dataset:
Acute Renal Failure Associated With Ticrynafen
Authors: Gary L. Paddack
Journal: JAMA (1980)

Three patients experienced acute renal failure temporally related to the use of ticrynafen. There was no clinical evidence of hypersensitivity. In all three patients, the serum uric acid level fell as they became more azotemic. It is postulated, but not proved, that acute tubular obstruction with urates may be responsible.  ( JAMA 243:764-765, 1980)
An instrumental variable approach finds no associated harm or benefit with early dialysis initiation in the United States
Authors: Julia J. Scialla, Jiannong Liu, Deidra C. Crews, Haifeng Guo, Karen Bandeen-Roche, Patti L. Ephraim, Navdeep Tangri, Stephen M. Sozio, Tariq Shafi, Dana C. Miskulin, Wieneke M. Michels, Bernard G. Jaar, Albert W. Wu, Neil R. Powe, L Ebony Boulware
Journal: Kidney International (2014)

The estimated glomerular filtration rate (eGFR) at dialysis initiation has been rising. Observational studies suggest harm, but may be confounded by unmeasured factors. As instrumental variable methods may be less biased, we performed a retrospective cohort study of 310,932 patients who started dialysis between 2006 and 2008 and were registered in the United States Renal Data System in order to describe geographic variation in eGFR at dialysis initiation and determine its association with mortality. Patients were grouped into 804 health service areas (HSAs) by zip code. Individual eGFR at dialysis initiation averaged 10.8 ml/min per 1.73 m(2) but varied geographically. Only 11% of the variation in mean HSA-level eGFR at dialysis initiation was accounted for by patient characteristics. We calculated demographic-adjusted mean eGFR at dialysis initiation in the HSAs using the 2006 and 2007 incident cohort as our instrument and estimated the association between individual eGFR at dialysis initiation and mortality in the 2008 incident cohort using the two-stage residual inclusion method. Among 89,547 patients starting dialysis in 2008 with eGFR 5-20 ml/min per 1.73 m(2), eGFR at initiation was not associated with mortality over a median of 15.5 months (hazard ratio, 1.025 per 1 ml/min per 1.73 m(2) for eGFR 5-14 ml/min per 1.73 m(2); and 0.973 per 1 ml/min per 1.73 m(2) for eGFR 14-20 ml/min per 1.73 m(2)). Thus, there was no associated harm or benefit with early dialysis initiation in the United States.
Mepacrine induced hepatitis.
Authors: W Gibb, D A Isenberg, M L Snaith
Journal: Annals of the Rheumatic Diseases (1985)

New antigens might be exposed through the trauma, leading to the development of autoimmune phenomena.This hypothesis is supported by other studies,' ' which tend to indicate that ankylosing spondylitis is a reactive arthritis following infection with various gram-negative organisms.Cross reactivity between infecting organisms and self components could be involved.The reason why some individuals develop Reiter's syndrome and others ankylosing spondylitis remains a mystery.It will be informative to seek differences in the genetic map of HLA-B27 positive patients which give rise to either disease.
BURIED SUTURES AND LIGATURES.THEIR MATERIAL AND PROPER USE.
Authors: WALTER B. CHASE
Journal: JAMA (1907)

As the use of buried sutures and ligatures constitutes an important part of most operative procedures, their selection and application is of far-reaching consequence. To some these considerations seem so elementary as to be unworthy of more than passing notice, but to my mind they are so fundamental in their relation to the domain of operative surgery as to demand such critical examination as will lead to their safe employment. In fact, the outcome of most cutting operations will fail in the full measure of their beneficent purpose, in the proportion which the operator fails to comprehend the scientific basis of their employment.  It is universally conceded that simplicity in the art and technic of surgery is the purpose and endeavor of those who stand as its best representatives, and that, other things being equal, a close adherence to these principles marks the radical difference between the successful and unsuccessful
Improved diagnosis of farmer's lung using the fluorescent antibody technique
Authors: G. Boyd, D. Parratt
Journal: Thorax (1974)

<b>Boyd, G. and Parratt, D. (1974).</b><i>Thorax</i>, <b>29</b>, 417-420. <b>Improved diagnosis of farmer9s lung using the fluorescent antibody technique.</b> In the west of Scotland 20 of 40 farmers surveyed had symptoms of farmer9s lung. Ten of this group (50%) gave positive precipitin reactions to <i>Micropolyspora faeni.</i> The fluorescent antibody test was positive in all those with symptoms and also in one who had no clinical evidence of farmer9s lung. There was a close relationship between evidence of sensitization to <i>M. faeni</i> in the serum, demonstrated by the fluorescent antibody test, and the presence of symptoms compatible with farmer9s lung. This test may detect the disease in milder form than is possible by conventional precipitin tests and this study confirms the value of this more sensitive technique as a screening procedure.
Therapeutic Endoscopy of the Paranasal Sinuses
Authors: W. Draf
Journal: Endoscopy (1978)

This paper is mainly concerned with describing and demonstrating the technique of paranasal endoscopies — maxillary, frontal, sphenoidal —, illustrated by diagrams. The improvement of technique in diagnosis and therapy of the paranasal sinuses has proved essentially successful. Indications for therapeutic endoscopy of paranasal sinuses are: 1. Purulent sinusitis. 2. Polypous and purulent sinusitis in children. 3. The so-called "mucosinus" 4. Removal of solitary cysts. 5. Removal of tooth fillings and roots. The different procedures are described.
Government announces army of 133 to rescue England's NHS
Authors: J. Jones
Journal: BMJ (2000)

The “great and the good” of England's healthcare establishment and a “new model army” of Blairite innovators have beenmobilised to draw up a plan to revitalise the NHS—by July (1 April, p 889)

A full membership list for the six task forces (modernisation action teams)was published by the Department of Health last week. The 133 name call up reveals an eclectic and potentially explosive mix.

The Department of Health summed up the composition of the task forces as “leading and frontline doctors, nurses, patients, managers and other NHS staff.”

Close inspection of the list, however, also reveals that substantial numbers of bureaucrats and government officials are getting a slice of the action.

Senior managers, executives, and …
SUDDEN DEATH UNDER AN ANAESTHETIC
Authors: D. Guthrie
Journal: BMJ (1919)

19!9 EIA OR fifty-six deaths recorded in the Proceedings of the Royal Society of Medicine would not have occurred.When the anaesthetic is given by a skilled anaesthetist and the operator is an expert the question is a little altered, but in hospital practice, where one is dependent upon continually changing house-surgeons, anaesthesia becomes very dangerous, whichever anaesthetic is used.-Iam, etc., Birmingham, July 15th.
Dipyridamole in Treatment Of Angina Pectoris
Authors: Augustus Gibson
Journal: JAMA (1968)

<h3>To the Editor:—</h3> The article by Sbar and Schlant, "Dipyridamole in Angina Pectoris," should not be considered a negative result but rather an inconclusive result. At least one point deserves comment. Two of the parameters used in judging the effect of therapy, the frequency of attack and the number of nitroglycerine tablets used, could have been expresssed in quantitative terms. I do not know what the result of the study would have been had this been done but such quantitative treatment would have permitted a more sensitive analysis of the findings. Even more important, however, is that the number of subjects reported in this study is so small as to greatly reduce the power of the test and make almost inevitable a type two error, the probability of accepting a null hypothesis when it may indeed be false. It is generally accepted that a considerable percentage of patients with angina
Input Impedance of the Systemic Circulation
Authors: MICHAEL F. O'ROURKE, MICHAEL G. TAYLOR
Journal: Circulation Research (1967)

The hydraulic load presented to the left ventricle by the systemic circulation was characterized by expressing pressure-flow relationships in the ascending aorta as input impedance. This was determined by spectral or Fourier analysis of simultaneously recorded pressure and flow waves in 1 unanesthetized and 27 anesthetized dogs. Impedance modulus fell steeply from its value at zero frequency (the peripheral resistance) and its value was lowest (less than 1/20th of the peripheral resistance) over that band of frequencies (usually between 1.5 and 10 cycle/sec) which contained most of the energy of the left ventricular ejection (flow) wave. The patterns of modulus and phase of ascending aortic impedance were found to result from the presence of two functionally discrete reflecting sites in the systemic circulation, one in the upper part of the body and the other in the lower. The presence of these two sites appears to be an important factor in maintaining a low impedance modulus between 1.5 and 10 cycle/sec, and so in providing a favorable impedance to pulsatile flow from the heart. Both modulus and phase of impedance in the ascending aorta showed changes similar to those seen in other arteries when blood pressure was altered and when vasodilation occurred in the vascular bed.
Fusion of optical imaging and MRI for the evaluation and adjustment of macroscopic models of cardiac electrophysiology: A feasibility study
Authors: Mihaela Pop, Maxime Sermesant, Damien Lepiller, Michael V. Truong, Elliot R. McVeigh, Eugene Crystal, Alexander Dick, Herve Delingette, Nicholas Ayache, Graham A. Wright
Journal: Medical Image Analysis (2008)
Aortic Expansion Rate in Patients With Dilated Post-Stenotic Ascending Aorta Submitted Only to Aortic Valve Replacement
Authors: Mario Gaudino, Amedeo Anselmi, Mauro Morelli, Claudio Pragliola, Vasileios Tsiopoulos, Franco Glieca, Gianfederico Possati
Journal: Journal of the American College of Cardiology (2011)
Global gene repression in hepatocellular carcinoma and fetal liver, and suppression of dudulin-2 mRNA as a possible marker for the cirrhosis-to-tumor transition
Authors: Cédric Coulouarn, Céline Derambure, Grégory Lefebvre, Romain Daveau, Martine Hiron, Michel Scotte, Arnaud François, Maryvonne Daveau, Jean-Philippe Salier
Journal: Journal of Hepatology (2005)
A centre of excellence in Africa.
Authors: A Cockshott
Journal: BMJ (1981)

Encapsulated in a naivety born of expectations and excitement, I'd given little thought to what my Africa experience would be like.One can talk too freely of "culture shock," but it existed for me in my slow attempts to adapt to my new environment.For the tourist or the professional an arrival in a new country can be smooth and untraumatic, but the student sees the differences more acutely as he is thrown unprotected into strange ETHIOPIA surroundings meeting new people, habits, sights, sounds, and smells.Kenya is a country of contrasts.Nairobi stands at a high altitude RIFT VALLE and is a cool city in August.
Functional Disorders of the Gut
Authors: Kevin W. Olden
Journal: Annals of Internal Medicine (1999)

Medical Writings: Book Notes5 October 1999Functional Disorders of the GutKevin W. Olden, MDKevin W. Olden, MDMayo Clinic Scottsdale, Scottsdale, Arizona. (Olden)Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-131-7-199910050-00037 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail Phillips SF, Wingate DL, eds. 370 pages. London: Churchill Livingstone; 1998. $50.00. ISBN 0443054207. Order phone 800-543-1918.Field of medicine: Gastroenterology, internal medicine, and primary care.Format: Hardcover book.Audience: Gastroenterology fellows, practicing gastroenterologists, and residents in internal medicine and family practice.Purpose: To present a cohesive review of the biology of functional gastrointestinal disorders and a systematic approach to the treatment of these disorders.Content: The first section reviews the epidemiology and anatomic, physiologic, and psychological substrates of the functional gastrointestinal disorders. Two interesting chapters on chronic abdominal pain and hypersensitivity and food intolerance are included. The second section ... Author, Article, and Disclosure InformationAffiliations: Mayo Clinic Scottsdale, Scottsdale, Arizona. (Olden) PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 5 October 1999Volume 131, Issue 7Page: 555KeywordsAbdominal painBiliary systemEpidemiologyEsophagusFoodGastroenterology and hepatologyHypersensitivitySoftware toolsSystematic reviews ePublished: 15 August 2000 Issue Published: 5 October 1999 Copyright & PermissionsCopyright © 1999 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Centre proposes limited use of drugs before phase III trials to speed innovation
Authors: N. Hawkes
Journal: BMJ (2013)

Oxford University and University College London have launched a new centre designed to turn scientific creativity into cures more swiftly and effectively. 

The Centre for Advancement of Sustainable Medical Innovation will be directed by Richard Barker, former director general of the Association of the British Pharmaceutical Industry. It brings together many experts to try to solve what it calls one of the most important problems of the 21st century: transforming bioscience into benefits for patients.

Barker said, “We will tackle the three main ‘gaps in translation’: breakthroughs in the lab not producing therapies for trial; too …
630 Hepatocyte proliferation in hepatitis C: Correlation with degree of liver injury and serum alpha-fetoprotein
Authors: P CANCHIS, L PETROVIC, F AHMED, J DAVILA, M FIEL, S KIM, A TEIXEIRA, L CHIRIBOGA, H YEE, B EDLIN
Journal: Hepatology (2003)

CTLA-4 is a key immune checkpoint in maintaining self-tolerance, which can be co-opted by cancer to evade immune attack. In Science, Kuehn et al. (2014) describe clinical manifestations from inherited heterozygous CTLA4 mutations, and some are reminiscent of immune-related consequences from anti-CTLA-4 cancer therapy.
Mannequins have feelings too
Authors: Robert William Menzies
Journal: BMJ (2008)

In the world of reality television, C-list and would-be celebrities act as guinea pigs for whatever social experiment takes the producer’s fancy. Extended periods of isolation, food rationing, verbal abuse, exposure to potentially harmful animals—nothing, it seems, is deemed ethically out of bounds. 

Thankfully, the ethical guidelines governing medical research bear no resemblance to those apparently operating in television. But, as a clinician struggling to get my first research project off the ground, I am wondering if we haven’t drifted too far to the other extreme of “ethical correctness.”

My particular study is to assess the ability of paramedics to use a new airway device. The aim is to establish that the device is suitable for paramedics in a simulated scenario using a mannequin, a pilot study to a future trial with live participants. There seemed …
Endoscopic Application of Human Fibrin Sealant in the Treatment of Solitary Rectal Ulcer Syndrome
Authors: A. Ederle, G. Bulighin, P. G. Orlandi, S. Pilati
Journal: Endoscopy (1992)

See also: “The Evolution of the Solitary Ulcer of the Rectum” - An Endoscopic and Histopathological Study -Endoscopy 1982; 14(04): 131-134DOI: 10.1055/s-2007-1021600
Obesity and Hypertension
Authors: Harriet P. Dustan
Journal: Diabetes Care (1991)

There is a close association of obesity with hypertension through mechanisms not now understood. Hypertension occurs frequently in industrialized societies where weight gain with advancing years is a common feature and is rare in primitive societies where weight and age are negatively correlated. Hemodynamically, obesity is characterized by an expanded blood volume and increased cardiac output. Hypertension results if/when systemic vascular resistance fails to decrease as cardiac output increases. When calorie restriction leads to weight loss, both blood volume and cardiac output decrease; when the blood pressure falls, this is because peripheral resistance is unchanged. Weight-loss programs are helpful for the obese hypertensive because when hypertension is mild, blood pressure often (but not always) normalizes. Also, weight loss has been shown to decrease antihypertensive drug requirements. Interest in obesity-associated hypertension focuses on hyperinsulinemia/insulin resistance as causative factors. Although the evidence is tempting, it is far from conclusive and it seems likely that the mechanism of this type of hypertension is as multifactorial as those of other types.
DIPHTHERIA INFECTION OF ANTRUM
Authors: F. F. Abbott
Journal: JAMA (1926)

<h3>To the Editor:</h3> —InThe Journal, October 2, under Queries and Minor Notes, a physician in Connecticut inquires regarding a diphtheria infection in the antrum of Highmore. In 1924, I had a similar case. The patient was superintendent of public schools in a nearby town. Cultures sent to the state laboratory were pronounced nonvirulent, which probably accounted for the fact that there were no contact cases. The infection was resistant to washings but cleared up promptly after the making of adequate drainage under the turbinate and the use of diphtheria antitoxin directly into the antrum.
The Evolution of a Health Team
Authors: J. Fry, J. B. Dillane, M. M. Connolly
Journal: BMJ (1965)

We present this paper for two reasons; first, to describe the effects of an attachment of a health visitor to a London suburban practice, and, second, to enumerate for others what we feel should be the necessary steps for success. The PracticeThe practice is sited in a south-east London suburb in a middle-class residential area.Its size (in June 1964) was 7,250, and there were 550 children under the age of 5. Some patients live as far as 3 miles (4.8 km.) away, but the majority live within 1 mile (1.6 km.).Following a preliminary secondment of health visitors for two weekly phild-welfare sessions, arrangements were made in 1963 for a total attachment to the practice.The health visitor's work was to be concerned entirely with the persons in the practice and she was to have no regular outside com- mitments.Present Routine.-Since the start of our association we have worked out a routine which works smoothly and efficiently.Briefly, a typical day consists of a meeting of health visitor, doctors, and clerical staff before morning surgery to discuss referral of patients by the doctors and a report by the health visitor on any problems found during the previous day.The health visitor then goes on her visits by car, while the doctors carry out the morning's consultations.There is an afternoon session every weekday and a further meeting of doctors and health visitor takes place.On one afternoon there is an ante- natal clinic, on another the doctor has his child-welfare clinic at which the health visitor is present, and on one afternoon the health visitor carries out her own child-welfare clinic with no doctor in attendance.As a rule the health visitor finishes her work by the time the evening consulting session starts, at 5 p.m.She usually takes her records home for completion and analysis.
Comparison of debulking followed by stenting versus stenting alone for saphenous vein graft aortoostial lesions: immediate and one-year clinical outcomes
Authors: Javed M Ahmed, Mun K Hong, Roxana Mehran, Gary S Mintz, Alexandra J Lansky, Augusto D Pichard, Lowell F Satler, Kenneth M Kent, Hongsheng Wu, Gregg W Stone, Martin B Leon
Journal: Journal of the American College of Cardiology (2000)
Firearm Injury Prevention
Authors: Robert Starkenburg
Journal: Annals of Internal Medicine (1998)

Letters1 November 1998Firearm Injury PreventionRobert Starkenburg, MDRobert Starkenburg, MDRaleigh, NC 27612Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-129-9-199811010-00028 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:The American College of Physicians position paper on firearms injury prevention [1] argues against the carrying of concealed weapons by average citizens, asserting that such restrictions are “self-explanatory.” To the contrary, Lott and Mustard [2], using cross-sectional time series crime data for all U.S. counties from 1977 to 1992, found that allowing citizens without criminal records or histories of significant mental illness to carry concealed weapons deterred violent crime and produced no increase in accidental deaths. When state laws permitting concealed handguns went into effect in a county, murders decreased by an average of 8.5%, rapes decreased ...References1. Firearm injury prevention. American College of Physicians. Ann Intern Med. 1998; 128:236-41. Google Scholar2. Lott JR, Mustard DB. Crime, deterrence, and right-to-carry concealed handguns. Journal of Legal Studies. 1997; 26:1-68. Google Scholar3. Bureau of Justice Statistics Crime Data Brief. Guns and Crime: Handgun Victimization, Firearm Self-Defense, and Firearm Theft (1987-92). April 1994, NCJ-147003. Google Scholar4. Kleck G. Point Blank: Guns and Violence in America. New York: Aldine de Gruyter; 1991. Google Scholar Author, Article, and Disclosure InformationAuthors: Robert Starkenburg, MDAffiliations: Raleigh, NC 27612 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byHospital visit histories of suicide decedents: a study in Utah 1 November 1998Volume 129, Issue 9Page: 751KeywordsAssaultCrimeFirearm injuriesHomicideViolent crime ePublished: 15 August 2000 Issue Published: 1 November 1998 Copyright & PermissionsCopyright © 1998 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Health Hazard Evaluation Program
Authors: Theodore W. Thoburn
Journal: JAMA (1981)

<h3>To the Editor.—</h3> In the article "Areawide Chemical Contamination: Lessons From Case Histories" by Robert W. Miller, MD (1981;245:1548), the overall theme is that the alert clinician evaluating the alert patient is often the key to recognition and correct diagnosis of diseases caused by environmental hazards. One source of help for the physician in evaluating such hazards, if they involve the workplace, is the Health Hazard Evaluation Program of the National Institute for Occupational Safety and Health (NIOSH), an institute in the Centers for Disease Control (CDC). A physician who suspects that he may have encountered disease caused by occupational exposure may obtain advice, consultation, or a full-fledged field investigation of the problem by contacting the Hazard Evaluation and Technical Assistance Branch at 4676 Columbia Pkwy, Cincinnati, OH 45226, telephone (513) 684-2176; program director, James Melius, MD. Assistance can also be obtained from any of the ten regional offices (Table).
P-32 Bremsstrahlung SPECT Helps Assess Intracavitary Therapy
Authors: BRENDA PETRI, ROBERT NANCE, JON HANADA, JEFFREY STEVENS
Journal: Clinical Nuclear Medicine (1992)

A patient underwent intracavitary P-32 chromic phosphate therapy for a chest tumor. Tc-99m sulfur colloid instilled before the P-32 demonstrated uniform distribution of activity throughout the right pleural space, and the P-32 was immediately administered. Ten days later, SPECT imaging using bremsstrahlung radiation of the P-32 showed an unexpected loculation of the P-32. A subsequent chest CT scan demonstrated pleural infolding and fluid localization in the same area as the P-32, indicating that the bremsstrahlung SPECT study had, in fact, documented the final localization of the P-32, which was unexpected and different from the initial localization. The procedure used in this case may be of value in documenting the ultimate distribution of intracavitary P-32.