tbuckley/cabot-search huggingface dataset:
Randomised controlled trial of cardiotocography versus Doppler auscultation of fetal heart at admission in labour in low risk obstetric population Commentary: changes between protocol and manuscript should be declared at submission Commentary: research governance must focus on research training Commentary: Approach to power calculations has to be realistic
Authors: G. Mires
Journal: BMJ (2001)

To compare the effect of admission cardiotocography and Doppler auscultation of the fetal heart on neonatal outcome and levels of obstetric intervention in a low risk obstetric population.Randomised controlled trial.Obstetric unit of teaching hospitalPregnant women who had no obstetric complications that warranted continuous monitoring of fetal heart rate in labour.Women were randomised to receive either cardiotocography or Doppler auscultation of the fetal heart when they were admitted in spontaneous uncomplicated labour.The primary outcome measure was umbilical arterial metabolic acidosis. Secondary outcome measures included other measures of condition at birth and obstetric intervention.There were no significant differences in the incidence of metabolic acidosis or any other measure of neonatal outcome among women who remained at low risk when they were admitted in labour. However, compared with women who received Doppler auscultation, women who had admission cardiotocography were significantly more likely to have continuous fetal heart rate monitoring in labour (odds ratio 1.49, 95% confidence interval 1.26 to 1.76), augmentation of labour (1.26, 1.02 to 1.56), epidural analgesia (1.33, 1.10 to 1.61), and operative delivery (1.36, 1.12 to 1.65).Compared with Doppler auscultation of the fetal heart, admission cardiotocography does not benefit neonatal outcome in low risk women. Its use results in increased obstetric intervention, including operative delivery.
The homeobox gene mirror links EGF signalling to embryonic dorso-ventral axis formation through Notch activation
Authors: Katherine C. Jordan, Nigel J. Clegg, Jennifer A. Blasi, Alyssa M. Morimoto, Jonaki Sen, David Stein, Helen McNeill, Wu-Min Deng, Michael Tworoger, Hannele Ruohola-Baker
Journal: Nature Genetics (2000)
Abstract 20029: Inhibition of Myostatin for the Prevention and Treatment of Cardiac Dysfunction after Aortic Constriction
Authors: Pablo A Quintero, Matthew Coggins, Chunyang Xiao, Anthony Rosenzweig
Journal: Circulation (2010)

Introduction: Myostatin (MSTN) is a secreted regulator of skeletal muscle growth recently recognized to increase in cardiac pathologies. MSTN inhibits the pro-survival kinase, Akt, and MSTN-null mice are protected against aging-related cardiac dysfunction and fibrosis. We hypothesized that increased cardiac MSTN is maladaptive and tested whether RAP-031, a murine analog of MSTN inhibitor (ACE-031) currently in clinical trials for skeletal muscle disease, could mitigate cardiac dysfunction after transverse aortic constriction (TAC). Methods: To see if RAP-031 could prevent cardiac dysfunction, wild-type (WT) FVB mice were randomized to RAP-031 (10mg/kg SQ, 2x/week) or vehicle. After 1 week, groups were further randomized to TAC (27G needle) or sham operation (N=5–7). Body weight, body composition by MRI, and cardiac function were followed for 12 weeks. To evaluate if RAP-031 could treat cardiac dysfunction, WT mice underwent TAC and when fractional shortening (FS) was ≥2STD below baseline were randomized t...
Abstract 4555: Long-term Outcomes of Drug-eluting vs Bare-metal Stents in Off-label Lesions: Results From the National Cardiovascular Database Registry (NCDR)
Authors: Art Sedrakyan, J M Brennan, David Dai, David Kong, Kevin Anstrom, Eric Eisenstein, Eric Peterson, Pamela S Douglas
Journal: Circulation (2009)

Background: Drug eluting stents (DES) are commonly used in the community for non-FDA approved indications. The long term outcomes of DES vs Bare Metal Stents (BMS) in these ‘off-label’ indications ...
ANGINA PECTORIS AS A PREDOMINATING SYMPTOM IN SPONTANEOUS HYPOGLYCEMIA
Authors: Joseph Weinstein, Bernard Mattikow
Journal: Annals of Internal Medicine (1939)

Case Reports1 May 1939ANGINA PECTORIS AS A PREDOMINATING SYMPTOM IN SPONTANEOUS HYPOGLYCEMIAJOSEPH WEINSTEIN, M.D., BERNARD MATTIKOW, M.D.JOSEPH WEINSTEIN, M.D.Search for more papers by this author, BERNARD MATTIKOW, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-12-11-1886 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptWhile the general symptomatology of hyperinsulinism has been known since Harris1 first recognized the syndrome in 1924, symptoms referable to the gastrointestinal tract, and vague generalized symptoms of varying degrees of severity as are usually observed in the psychoneuroses and in vasomotor disturbances have been the main features described.We wish to report two cases which have come under our observation in which the predominating symptom was angina pectoris.CASE REPORTSCase 1. A male, 42 years of age, gave a two year history of attacks of substernal pains radiating to both shoulders, coming on with exertion or excitement and...References1. HARRIS S: Hyperinsulinism and dysinsulinism, Jr. Am. Med. Assoc., 1924, lxxxiii, 729-733. CrossrefGoogle Scholar2. HARRIS S: Hyperinsulinism, a definite disease entity, Jr. Am. Med. Assoc., 1933, ci, 1958. CrossrefGoogle Scholar3. HARRIS S: The diagnosis of surgical hyperinsulinism, Southern Surgeon, 1934, iii, 199. Google Scholar4. HARRIS S: High carbohydrate-low fat diets in the treatment of diabetes mellitus and low carbohydrate-high fat diets in hyperinsulinism, Mississippi Doctor, 1936, 9-23. Google Scholar5. GRAHAMWOMACK EANA: The application of surgery to the hypoglycemic state due to islet tumors of the pancreas, Surg., Gynec. and Obst., 1933, lvi, 728-742. Google Scholar6. WILDERALLENPOWERROBERTSON RMFNMHHE: Carcinoma of the islands of the pancreas, Jr. Am. Med. Assoc., 1927, lxxxix, 348-355. CrossrefGoogle Scholar7. WOODYATT RT: Text-book of medicine (Cecil), 4th Edition, W. B. Saunders, Philadelphia, 1937, 650-652. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Brooklyn, New York*Received for publication March 29, 1938.From the M. A. Rabinowitz Medical Service of the Jewish Hospital of Brooklyn. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byDie Coronarerkrankungen. Coronarinsuffizienz, Angina pectoris und HerzinfarktAdenoma of the Islands of LangerhansCardiac Pain Due to Glucose Deficiency. ? Pituitary Dysfunction 1 May 1939Volume 12, Issue 11Page: 1886-1890KeywordsAnginaGastrointestinal tractHyperinsulinemiaHypoglycemiaMedical servicesPainShoulders ePublished: 1 December 2008 Issue Published: 1 May 1939 PDF downloadLoading ...
Contributions of the Raf/MEK/ERK, PI3K/PTEN/Akt/mTOR and Jak/STAT pathways to leukemia
Authors: L S Steelman, S L Abrams, J Whelan, F E Bertrand, D E Ludwig, J Bäsecke, M Libra, F Stivala, M Milella, A Tafuri, P Lunghi, A Bonati, A M Martelli, J A McCubrey
Journal: Leukemia (2008)
Abstract 4227: The ribonucleotide reductase inhibitor Didox reverses tamoxifen resistance in breast cancer cells
Authors: Khyati N. Shah, Howard L. Elford, Jesika S. Faridi
Journal: Cancer Research (2014)

Abstract Tamoxifen is the most prescribed endocrine therapy for estrogen receptor positive breast cancer patients. The emergence of endocrine resistance is a major hurdle in achieving a successful clinical outcome. Many advances have been made over the past few years to understand the biology of tamoxifen resistance. Activation of the AKT kinase is one of the primary mechanisms of intrinsic tamoxifen resistance. Previously, we reported that the Ribonucleotide Reductase M2 (RRM2) subunit is upregulated in AKT induced tamoxifen resistance and that inhibition of RRM2 by siRNA mediated interference reduces tamoxifen induced cell proliferation. In this study, we report that the inhibition of RRM2 by the small molecule inhibitor of ribonucleotide reductase activity Didox (3, 4-dihydroxybenzohydroxamic acid), significantly reduced tamoxifen induced cell proliferation in AKT overexpressing cells and tamoxifen resistant tumors generated by these cells. As well, Didox in combination with tamoxifen also inhibited cell proliferation in acquired tamoxifen resistant breast cancer cell lines. Employing comprehensive cell culture and in vivo models, we demonstrate that combining tamoxifen with Didox may reverse tamoxifen resistance in AKT expressing breast cancer cells. Citation Format: Khyati N. Shah, Howard L. Elford, Jesika S. Faridi. The ribonucleotide reductase inhibitor Didox reverses tamoxifen resistance in breast cancer cells. [abstract]. In: Proceedings of the 105th Annual Meeting of the American Association for Cancer Research; 2014 Apr 5-9; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2014;74(19 Suppl):Abstract nr 4227. doi:10.1158/1538-7445.AM2014-4227
Abstract P049: Race/Ethnic Differences in Patterns of Antihypertensive Medication Uptake and Clinical Outcomes among Hospitalized Diabetic Patients with Hypertension
Authors: Heidi Mochari-Greenberger, Lori Mosca
Journal: Circulation (2014)

Background: Hypertension increases the risk of complications in patients with diabetes. Race/ethnic differences in the uptake of antihypertensive medications may contribute to disparities in clinical outcomes, but this has not been formally evaluated. We aimed to assess patterns of antihypertensive medication prescription by race/ethnic group and the association with clinical outcomes among hospitalized diabetic patients with hypertension. Methods: This was a 1 year prospective study of individuals with existing diabetes and hypertension (N=1126, 42% black/Hispanic [minority]; 39% female) that participated in an NHLBI clinical outcomes study of patients admitted to a cardiovascular service. Baseline clinical/medication data and outcomes (rehospitalization/death) were documented by electronic medical record, National Death Index, and standardized mail survey. Logistic regression was used to evaluate associations between race/ethnicity, antihypertensive prescription, and outcomes adjusted for demographics/comorbidities. Results: Overall utilization of antihypertensive medication prior to admission did not differ between minority (92%) vs. white/other (93%) patients; minorities were more likely to report taking calcium channel blockers (OR=1.40;95%CI=1.08-1.81) and less likely to use beta blockers (OR=0.65;95%CI=0.50-0.84) vs. whites/others. Race/ethnic differences in prescription type did not persist at discharge after adjustment for demographics/comorbidities (96% prescribed any antihypertensive medication: 62% ACE inhibitor/ARB, 81% beta blocker, 29% calcium channel blocker, 48% diuretic). A total of 676 (60%) of participants were rehospitalized/dead at 1 year; predictors of rehospitalization/death included minority race/ethnicity, lack of health insurance, renal failure/dialysis, peripheral vascular disease, and heart failure (p&lt;0.05). Prescription of beta blocker (OR=0.60;95%CI=0.43-0.82) was associated with lower odds of rehospitalization/death at 1 year. Race/ethnic minority status remained a significant predictor of death/rehospitalization at 1 year after adjustment demographics, comorbidities and beta blocker prescription at discharge (OR=1.31;95%CI=1.01-1.71). Conclusion: In this study of hospitalized diabetic patients with hypertension, antihypertensive prescription at discharge did not vary by race/ethnicity; beta blocker prescription at discharge was associated with lower odds of rehospitalization/death at 1 year. Higher odds of rehospitalization/death among minorities was not explained by measured covariates including type of antihypertension medication.
Failure of Corynebacterium parvum Presensitization To Modify the Antitumor Effects of Systemic and Local Therapeutic Iniections of C. parvum in Mice 2
Authors: Martin T. Scott
Journal: JNCI Journal of the National Cancer Institute (1976)

Journal Article Failure of Corynebacterium parvum Presensitization To Modify the Antitumor Effects of Systemic and Local Therapeutic Iniections of C. parvum in Mice Get access Martin T. Scott Martin T. Scott 3Trudeau Institute Inc., Saranac Lake, N.Y. 12983. 4Present address: Department of Experimental Immunobiology, Wellcome Research Laboratories, Beckenham, Kent BR3 3BS, England. 5The excellent technical assistance of Sandra L. Warner is gratefully acknowledged. Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 56, Issue 3, March 1976, Pages 675–677, https://doi.org/10.1093/jnci/56.3.675 Published: 01 March 1976 Article history Received: 12 August 1975 Accepted: 26 September 1975 Published: 01 March 1976
Abstract 11642: Exposure to Fine Particulate Matter is Associated With Progression of Subclinical Atherosclerosis: Systematic Review and Meta-Analysis
Authors: Emmanuel Akintoye, Liuhua H Shi, Itegbemie Obaitan, Mayowa Olusunmade, Yan Wang, John A Dodson
Journal: Circulation (2014)

Introduction: Individual studies have suggested an association between exposure to fine particulate matter (PM with aerodynamic diameter ≤2.5μm [PM2.5]) and atherosclerosis progression using carotid intimal medial thickness (CIMT), but their generalizability is limited. We therefore conducted a systematic review and meta-analysis of available literature in order to investigate the association of PM2.5 and atherosclerosis as measured by CIMT across multiple studies. Hypothesis: PM2.5 exposure is associated with atherosclerosis progression by CIMT. Methods: We performed a comprehensive search for studies published up to 3/2014 (Medline, Embase, Web of Science, Environmental Index) that evaluated any association between exposure to PM 2.5 and change in CIMT. Studies were selected based on predefined inclusion criteria. 5 authors reviewed eligible manuscripts and 2 authors independently extracted the data. We estimated the mean change in CIMT per 10μg/m2 increase in PM 2.5. Using random effects models, pooled...
Proteinase-activated receptor-2 and hyperalgesia: A novel pain pathway
Authors: N. Vergnolle, N.W. Bunnett, K.A. Sharkey, V. Brussee, S.J. Compton, E.F. Grady, G. Cirino, N. Gerard, A.I. Basbaum, P. Andrade-Gordon, M.D. Hollenberg, J.L. Wallace
Journal: Nature Medicine (2001)
Cerebral Folate Deficiency Syndrome
Authors: Michèl A A P Willemsen, Ron A Wevers, Marcel M Verbeek, Marcel M Vebeek
Journal: New England Journal of Medicine (2005)

report 28 patients with the cerebral folate deficiency syndrome characterized by decreased levels of 5-methyltetrahydrofolate (5MTHF) in the cerebrospinal fluid caused by autoantibodies' blocking of folate transport into the brain.The patients benefited from folinic acid supplementation.The clinical features of this syndrome fit with other neurodegenerative disorders.3][4] The authors do not report the presence or absence of folate-receptor autoantibodies in secondary cerebral folate deficiency.Before claiming that the cerebral folate deficiency syndrome is a separate entity, the investigators should demonstrate that it is a unique, autoantibody-mediated disease, different from secondary cerebral folate deficiency.
A History of Surgery with Emphasis on the Netherlands
Authors: Daniel de Moulin
Journal: Annals of Internal Medicine (1988)

Antiquarian interest apart, the value of the book for students of ancient medicine ultimately depends on the quality of Caius' textual criticism.As far as the modern editor is concerned, this value is not great.Caius' knowledge of Greek was not particularly sensitive (certainly he was not as good as Cornarius).Nutton is realistic about this throughout, yet he shows a considerable amount of charity towards his subject.He sees Caius as an important figure in the history of Galenic textual scholarship because "a modern editor of Galen is perforce a pioneer"; as a witness to the reading of certain manuscripts, "his pedantry here proves to be a virtue".Nutton himself indicates what might be stressed rather more: that much of Caius' work on Galen was polemically motivated, with an eye on contemporary rivals.Galen had established the precedent, in "reinterpreting" Hippocrates to the point not only where Hippocrates could do no wrong, anticipating much of the natural philosophy of Plato and Aristotle, but also to the point where he was always in agreement with Galen.The case seems to have been similar with Caius.In my view, we are not dealing here with a transparent case of a medical philologist at work.I came away from this book with a far higher regard for Dr Nutton's historical detective work than for Dr Caius' reaction and pedantry.
Abstract P2-05-01: The non-coding transcriptome of hypoxic breast cancer: Novel insights of clinical relevant long non-coding RNA in hypoxia signalling
Authors: Hani Choudhry, Johannes Schodel, Ashwag Albukhari, Syed Haider, Francesca Buffa, Peter J Ratcliffe, David R Mole, Ioannis Ragousis, Adrian L Harris
Journal: Cancer Research (2015)

Abstract Hypoxia is associated with aggressive and poor prognosis of breast cancer. Generally, pan-genome analyses of hypoxia have focussed on protein-coding genes, however, the role of non-coding RNAs, in particular long non-coding RNAs (lncRNA) in hypoxia is not well characterised. We undertook an integrated genomic analysis of the hypoxic transcriptome in MCF7 breast cancer cells, employing total RNA-seq together with ChIP-seq for the hypoxia-inducible transcription factor (HIF) and for epigenetic marks of transcriptional activation (RNApol2 and histone H3K4me3). Analyses revealed that all classes of RNA are significantly regulated by hypoxia including piwiRNA, miRNA, tRNA, and sn/snoRNA. Significant numbers of lncRNAs were upregulated in hypoxia and were associated with increased RNApol2 and H3K4me3 markers and with HIF binding, indicating direct transcriptional activation of lncRNAs by HIF. The most hypoxiclly upregulated lncRNA was NEAT1, which is a direct transcriptional target of HIF-2a but not HIF-1a. The role of NEAT1 in cancer has not been previously studied. We demonstrated that hypoxic NEAT1 induction is common in breast cancer cell lines and xenografts models treated with bevacizumab. NEAT1 directly induces the formation of nuclear paraspeckle bodies in hypoxia. Moreover, it contributes to tumourigenicity by increasing cell proliferation, colony formation, and reducing apoptosis. In addition, we report that NEAT1 is required to retain hypoxia induced hyper edited Junctional Adhesion Molecule A (JAM-A) mRNA in the nucleus, thus preventing export into the cytoplasm for translation. Finally, in a large cohort of 2000 breast cancers, high levels of NEAT1 were associated with poor clinical outcomes and clinicopathological features. Our results extend knowledge of the hypoxic transcriptional response into the spectrum of non-coding transcripts. These findings provide novel mechanisms of transcriptional regulation in hypoxia and open new avenues to find novel pathways and targets to develop therapies for breast cancer. Citation Format: Hani Choudhry, Johannes Schodel, Ashwag Albukhari, Syed Haider, Francesca Buffa, Peter J Ratcliffe, David R Mole, Ioannis Ragousis, Adrian L Harris. The non-coding transcriptome of hypoxic breast cancer: Novel insights of clinical relevant long non-coding RNA in hypoxia signalling [abstract]. In: Proceedings of the Thirty-Seventh Annual CTRC-AACR San Antonio Breast Cancer Symposium: 2014 Dec 9-13; San Antonio, TX. Philadelphia (PA): AACR; Cancer Res 2015;75(9 Suppl):Abstract nr P2-05-01.
Abstract 20105: Sympathetic Nervous Dysregulation Without Systolic Dysfunction in a Rat Model of Insulin Resistance with Sustained Hyperglycemia
Authors: James T Thackeray, Jerry Radziuk, Mary-Ellen Harper, Kathryn J Ascah, Rob S Beanlands, Jean N DaSilva
Journal: Circulation (2010)

Chronic diabetes and insulin resistance are associated with cardiovascular disease and dysregulation of cardiac sympathetic nervous system (SNS) characterized by persistent elevation of plasma and ...
Abstract 16025: Continuous Positive Airway Pressure Therapy as a Therapy for Cardiac Arrhythmias: Meta - Analysis of 14 Studies
Authors: Waqas Qureshi, Usama b Nasir, Zeeshan Ali, Shayan Qadir, Muhammad K Hayat-Syed, Shehabaldin Alqalyoobi, Sagger Mawri, Mouaz H Al-Mallah
Journal: Circulation (2014)

Introduction: Obstructive sleep apnea (OSA) is a risk factor for cardiac arrhythmias. Continuous positive airway pressure (CPAP) as a therapy of these arrhythmias is not well established. Hypothesis: We performed a meta-analysis of prospective cohort studies and randomized controlled trials to evaluate effect of CPAP on cardiac arrhythmias. Methods: MEDLINE, EMBASE, Cochrane databases, GoogleScholar and WebofScience from inception to June 2014 were searched for prospective cohort and intervention studies reporting that had CPAP as intervention and cardiac arrhythmia as an outcome measure. Two authors independently assessed study quality and extracted data. Random effects model was used to estimate pooled effect of CPAP on burden as well as number of events of cardiac arrhythmias. Between-study heterogeneity was assessed by I2 method. Results: Ten prospective cohort studies and four randomized controlled trials were included. There were a total of 1246 individuals that underwent CPAP therapy and 1213 were in comparison group. In random-effect models, CPAP was associated with decreased risk of cardiac arrhythmia (pooled Risk Ratio 0.62; 95% CI 0.41 - 0.93, p = 0.02) as well as burden of cardiac arrhythmia (mean difference in electrocardiographic abnormality -14.6; 95% CI -23.6 - -5.7, p = 0.002). Significant heterogeneity was present in studies (I2 = &gt;90%). Type of cardiac arrhythmia (atrial vs. ventricular) explained most of the heterogeneity; with greater effect of CPAP on reducing atrial rather than ventricular arrhythmia. Forest plots are given in the figure. Conclusions: CPAP appears to be effective in treatment of cardiac arrhythmia in OSA patients. The effect is greater for atrial arrhythmia than ventricular arrhythmia. Long term studies evaluating this effect on mortality are needed.