THE USE OF MIXTURES OF PROTAMINE ZINC AND REGULAR INSULIN
Authors: R G SPRAGUE
Journal: Annals of Internal Medicine (1949)

Article1 October 1949THE USE OF MIXTURES OF PROTAMINE ZINC AND REGULAR INSULINRANDALL G. SPRAGUE, M.D., F.A.C.P.RANDALL G. SPRAGUE, M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-31-4-628 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptDuring the past 10 years a considerable experience in the use of adjustable mixtures of protamine zinc and regular insulin in the Section on Metabolism Therapy of the Mayo Clinic has led to the formation of certain opinions about the usefulness and limitations of this method of insulin therapy of diabetes. Among other things, it has become apparent that appropriate mixtures, because of the intermediate character of their action with respect to onset, intensity and duration, have great usefulness in cases of moderately severe to severe diabetes. It is in these cases that protamine zinc insulin, used alone, lacks sufficient...Bibliography1. SPRAGUEFOLEY AWMA: The education of the diabetic patient, Hosp. Management, 1940, l, 41-44. Google Scholar2. COLWELL AR: Nature and time action of modifications of protamine zinc insulin, Arch. Int. Med., 1944, lxxiv, 331-345. CrossrefGoogle Scholar3. MACBRYDEROBERTS CMHK: Modified protamine zinc insulin: an improvement on standard protamine zinc insulin; comparative studies on 62 diabetic patients, Jr. Am. Med. Assoc., 1943, cxxii, 1225-1231. CrossrefGoogle Scholar4. PECK FB: Insulin mixtures and modifications, Proc. Am. Diab. Assoc., 1946, vi, 273-300. Google Scholar5. LAWRENCE RD: The treatment of insulin cases by one daily injection, Acta med. Scandinav., 1938, xc, 32-53. Google Scholar6. RICKETTS HT: Does hyperglycemia harm the diabetic patient? Med. Clin. North Am., 1947, xxxi, 267-277. CrossrefGoogle Scholar7. KIRKPATRICK NR: Experience with a new insulin, Proc. Staff Meet., Mayo Clin., 1949, xxiv, 365-370. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: *Read at the Thirtieth Annual Session of The American College of Physicians, New York, N. Y., March 31, 1949.†The diet kitchen provides a means whereby fairly rigid dietary control of diabetes can be maintained while the patients are ambulant and receiving instruction in the management of their disease. All servings of food are weighed or carefully estimated according to the requirements of the individual patient. Experience has shown that the patients learn more quickly and more satisfactorily when ambulant outpatients than they do in the hospital. From day to day they are permitted to assume increasing responsibility in their own care.1 By exchanging notes and experiences with other ambulant patients, and having regular conferences with physician and dietitian, the learning process is accelerated. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byInsulin Preparations with Prolonged EffectEvolution of modified insulins in the treatment of diabetes mellitus, with special emphasis on insulin-zinc suspensionsDiabetes Mellitus 1 October 1949Volume 31, Issue 4Page: 628-636KeywordsDietFoodInsulinOutpatient clinicsOutpatientsProtaminesZinc ePublished: 1 December 2008 Issue Published: 1 October 1949 PDF downloadLoading ...