AN APPARATUS FOR THE INTRODUCTION OF PENICILLIN AEROSOL INTO THE NASAL ACCESSORY SINUSES WITH A CASE REPORT OF A PATIENT WITH CHRONIC SINUSITIS
Authors: A L BARACH, B GARTHWAITE
Journal: Annals of Internal Medicine (1946)

Article1 January 1946AN APPARATUS FOR THE INTRODUCTION OF PENICILLIN AEROSOL INTO THE NASAL ACCESSORY SINUSES WITH A CASE REPORT OF A PATIENT WITH CHRONIC SINUSITISALVAN L. BARACH, M.D., F.A.C.P., BETTINA GARTHWAITE, M.D., MAX SOROKA, B.S., FREDERICK F. ANDERSONALVAN L. BARACH, M.D., F.A.C.P.Search for more papers by this author, BETTINA GARTHWAITE, M.D.Search for more papers by this author, MAX SOROKA, B.S.Search for more papers by this author, FREDERICK F. ANDERSONSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-24-1-97 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptIn a preliminary report1 the inhalation of nebulized penicillin in broncho-pulmonary infections was described. In some instances the mist of penicillin was inhaled through the nose with the idea that the sinuses might be in communication with the air in the nasal passages. However, in order to introduce penicillin aerosol into the sinuses, it was finally considered necessary to evacuate air from the sinuses by developing a negative pressure in the nasal passages with immediate replacement of air containing penicillin in high concentrations.†‡An apparatus was devised for production of penicillin aerosol with intermittent negative pressure in the nasal and...Bibliography1. BARACHSILBERSTEINOPPENHEIMERHUNTERSOROKA ALFHETTM: Inhalation of penicillin aerosol in patients with bronchial asthma, chronic bronchitis, bronchiectasis and lung abscess, Ann. Int. Med., 1945, xxii, 485. Google Scholar2. ANDREWSROTHIVY AHLWAC: On the use of reduced atmospheric pressure in the treatment of paranasal sinusitis, Quart. Bull., 1941, xv, 46. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: New York, N. Y.*Received for publication June 22, 1945.From the Department of Medicine, Columbia University, College of Physicians and Surgeons, New York City.The penicillin was provided by the Office of Scientific Research and Development from supplies assigned by the Committee on Medical Research for clinical investigations recommended by the Committee on Chemotherapeutics and Other Agents of the National Research Council.This research was aided by a grant from the Josiah Macy, Jr. Foundation.†We are indebted to Dr. George Foster Herben for suggesting the preliminary use of suction in combination with the penicillin reinhalation apparatus.‡Reduced atmospheric pressure in a low pressure chamber has been used with favorable results to provide effective suction and increase aeration of the sinuses and promote drainage.2 During the period when air reënters the nasal accessory sinuses no antibiotic substance was used in this procedure. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byProdrugs for nasal drug deliveryBibliographyGENERAL PHARMACOLOGY OF ANTIBIOTICSXV Penicillin Aerosol Therapy in SinusitisRecent Therapeutic Trends in AllergyAerosol therapyAerosol Therapy of Respiratory DiseasePenicillin aerosol therapy in bronchiectasis, lung abscess and chronic bronchitisStreptomycinPenicillin Inhalation TherapyPenicillin aerosol and negative pressure in the treatment of sinusitis 1 January 1946Volume 24, Issue 1Page: 97-103KeywordsAntibioticsChemotherapeutic agentsInhalationPenicillinSurgeons ePublished: 1 December 2008 Issue Published: 1 January 1946 PDF downloadLoading ...