Alpha-Difluoromethylornithine Infusion and Cardiac Arrest
Authors: RICK A. BARBARASH
Journal: Annals of Internal Medicine (1986)

Letters and Corrections1 July 1986Alpha-Difluoromethylornithine Infusion and Cardiac ArrestRICK A. BARBARASH, PHARM.D., LAURA TOLL, PHARM.D., STEVEN A. SAHN, M.D.RICK A. BARBARASH, PHARM.D.Search for more papers by this author, LAURA TOLL, PHARM.D.Search for more papers by this author, STEVEN A. SAHN, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-105-1-141_2 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: Alpha-difluoromethylornithine is an investigational antiprotozoal agent used to treat Pneumocystis carinii pneumonia in patients with the acquired immunodeficiency syndrome (AIDS) who are unresponsive to or intolerant of trimethoprim-sulfamethoxazole and pentamidine (1). We report the case of a patient who developed cardiac conduction disturbances leading to death during infusion of this agent.A 31-year-old woman was admitted with AIDS,P. cariniipneumonia, and respiratory failure requiring mechanical ventilation. She initially received intravenous trimethoprim-sulfamethoxazole (20 and 100 mg/kg body weight · d, respectively) but developed a maculopapular rash after 3 days, and intravenous pentamidine (4 mg/kg · d) was...References1. GOLDEN J, SJOERDSMA A, and SANTI D. Pneumocystis carinii pneumonia treated with α-difluoromethylornithine. West J Med. 1984;141:613-23. MedlineGoogle Scholar2. MURRAY J, FELTON C, and GARAY S. Pulmonary complications of the acquired immunodeficiency syndrome: report of a National Heart, Lung, and Blood Institute workshop. N Engl J Med. 1984;310:1682-8. CrossrefMedlineGoogle Scholar3. STOVER D, WHITE D, and ROMANO P. Spectrum of pulmonary disease associated with the acquired immune deficiency syndrome. Am J Med. 1985;78:429-37. CrossrefMedlineGoogle Scholar4. MITSUYASU R, GROOPMAN J, and VOLBERDING P. Cutaneous reaction to trimethoprim-sulfamethoxazole in patients with AIDS and Kaposi's sarcoma. N Engl J Med. 1983;308:1535-6. CrossrefMedlineGoogle Scholar5. GORDIN F, SIMON G, WOFSY C, and MILLS J. Adverse reactions to trimethoprim-sulfamethoxazole in patients with the acquired immunodeficiency syndrome. Ann Intern Med. 1984:100:495-9. LinkGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: RICK A. BARBARASH, PHARM.D.; LAURA TOLL, PHARM.D.; STEVEN A. SAHN, M.D.Affiliations: Medical University of South Carolina Charleston, SC 29425 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byThe impact of hypoxia on B cells in COVID-19AIDS and the heart: Clinicopathologic assessmentTrypanosomiase humaine africaine et myocardite. Traitement par difluorométhylornithineCardiac manifestations of acquired immune deficiency syndrome: A 1991 updateCardiac complications in acquired immunodeficiency syndrome (AIDS): A reviewEflornithine for the Treatment of Pneumocystis carinii Pneumonia in Patients with the Acquired Immunodeficiency Syndrome: A Preliminary Review 1 July 1986Volume 105, Issue 1Page: 141-142KeywordsAIDSBody weightHeartPneumocystis carinii pneumoniaPneumoniaRashesRespiratory failureVentilators ePublished: 1 December 2008 Issue Published: 1 July 1986 PDF downloadLoading ...