tbuckley/cabot-search huggingface dataset:
Biologic Properties of Three Newly Established Human Esophageal Carcinoma Cell Lines&lt;xref ref-type="fn" rid="FN2"&gt;2&lt;/xref&gt;
Authors: C P Hu, H G Hsieh, K Y Chien, P Y Wang, C I Wang, C Y Chen, S J Lo, K D Wuu, C M Chang
Journal: JNCI Journal of the National Cancer Institute (1984)

Three epithelial cell lines, CE-48T/VGH, CE-69T/-VGH, and CE-81T/VGH, were established from human squamous cell carcinoma of the esophagus. The cells were polygonal with a high nucleus-to-cytoplasm ratio. Many cells were multinucleate. Electron microscopy revealed the presence of tonofilaments and desmosomes. Chromosome analysis showed that these 3 cell lines were heteroploids of human origin. When transplanted into BALB/c (nu/nu) mice, CE-69T/VGH and CE-81T/VGH produced tumors, the histology of which proved to be carcinomas. All 3 cell lines secreted carcinoembryonic antigen. However, the secretion patterns were different. These 3 cell lines may provide useful models for the study of human esophageal cancer.
Lung cancer in Berlin - NET of the lung; analysis of subgroups and impact on survival (2000 - 2008)
Authors: Christian Gogoll, Torsten Blum, Stephan Eggeling, Christian Grohé, Christel Lauer, Gunda Leschber, Jens Neudecker, Wulf Pankow, Bernd Schicke, Paul Schneider, Nicolas Schoenfeld, Christian Witt, Anita Jagota
Journal: European Respiratory Journal (2013)

Introduction: 

A small proportion (∼3%) of patients with lung cancer show neuroendocrine (NE) differentiation other than small cell lung cancer. Only few is known about epidemiology, clinical features, best treatment, and follow-up.

Aims: to evaluate the subgroups of tumors of the lung with neuroendocrinic differentiation.

Methods: 

In this retrospective case study of pooled data of the Tumorzentrum Berlin of newly diagnosed lung cancer during 2000 and 2008

Results: 

The total cohort comprised 14,302 patients, in this group 254 had NE differentiation, without showing histology of SCLC (typical carcinoid 116 pt, NE carcinoma 116 pt, atypic carcinoid 22 cases). Predominantly women (57% vs 43%) had NE differentiation. Interstingly, we found an increasement of NE carcinoma associateted with a poorer prognosis. Although associated with an excellent prognosis in 3 case of typical carcinoid and 5 cases of atypical carcinoid distant metastases were found. NE carcinoma was found stage IV in 55 cases (47%). Prognosis is poor in NE carcinoma and better in atypic carcinoids (median survival 11 mo vs. 48 mo), whereas the best prognosis is found in typic carcinoids.

![Figure][1] 



Conclusion: 

According to the pooled data of the Tumorzentrum Berlin, the analyses of histology, epidemiologic data, and prognosis over an observation period of 9 years spotted an increase of NE carcinoma, associated with a poorer prognosis in this small subgroup.

 [1]: pending:yes
Conserved genetic networks define ER-alpha status and luminal and basal phenotypes in mouse and human mammary cancer: Added value from the mouse
Authors: Aleksandra M. Michalowska, Ting-Hu Qiu, Claudine Kavanaugh, Eva Y.-H.p. Lee, Daniel Medina, Xiaoling Xu, Chu-Xia Deng, John I. Powell, Joanna H. Shih, Jeffrey E. Green
Journal: Cancer Research (2006)

1551   Defining molecular similarities and differences between genetically engineered mouse models of mammary cancer and human breast cancer is critical to the further understanding of molecular mechanisms of oncogenesis and identifying models most relevant to human disease. One goal of this study was to use expression profiling in an attempt to determine whether several important, oncogenic pathway specific mouse models of mammary cancer could be classified according to the basal - luminal distinctions identified for human breast cancer. We demonstrate that all of the models studied in which p53 is mutated or functionally impaired and a BRCA1 mutant model cluster with human tumors in the basal-type category. All models in which the myc, ras, her2/neu and Polyoma middle T-antigen are driven by the MMTV promoter share molecular characteristics that cluster them with human luminal-type breast tumors. Interestingly, these models have been shown to lack ER-alpha expression (which is strongly associated with lack of GATA-3 expression in human breast cancers), but high expression of transcription factor GATA-3 is observed in our data for these models. A third group of mouse tumors include ER+ tumors arising from the p53fp/fp;Wap- cre  model, which cluster with ER+ human tumors representing the luminal type A group. This new classification of GEM models provides a rational approach for further investigating the cellular origins of the different tumor classes and the appropriate use of the models in relation to the human tumor subclasses, especially pre-clinical testing. A second objective of this study was to determine whether mouse and human breast cancers share gene signatures based upon the status of ER expression. We have performed the first supervised comparison of gene expression profiles from mouse ER+ and ER- mammary tumors (generated by the mammary-specific conditional knock-out mutation of the p53 gene) with that of ER+ and ER- human breast tumors. Direct integration of gene expression levels from mouse tumors with that from human tumors (based upon ER expression) resulted in the most accurate classifier for ER status in human breast cancer, demonstrating the important added value of mouse data generated in a well-defined genetic background. The mouse-human ER classifier represents a set of genes co-expressed between mouse and human and can be placed into evolutionarily conserved networks based upon estrogen signaling. This approach reveals functionally conserved genes and networks across species important for cancer biology and identifying potential new therapeutic targets.
Extramedullary Waldenström macroglobulinemia
Authors: Ranjit Banwait, Yosra Aljawai, Joseph Cappuccio, Serena McDiarmid, Elizabeth A. Morgan, Houry Leblebjian, Aldo M. Roccaro, Jacob Laubach, Jorge J. Castillo, Claudia Paba‐Prada, Steven Treon, Robert Redd, Edie Weller, Irene M. Ghobrial
Journal: American Journal of Hematology (2014)

Disease assessment in Waldenstrom Macroglobulinemia (WM) is dependent on the percent involvement of B-cell neoplasm in the bone marrow and IgM paraprotein in the serum. A subset of patients also demonstrates extramedullary involvement, which is infrequently examined. The role of extramedullary involvement in the diagnosis and prognosis of WM is poorly understood. The purpose of this study is to report the characteristics of WM patients with extramedullary disease (EMD). Nine hundred and eight-five patients with WM were evaluated at one academic center and the presence of EMD was assessed in these patients. Forty-three (4.4%) patients were identified to have EMD. Nine (21%) patients presented with involvement at WM diagnosis, while 34 (79%) developed EMD post-therapy for WM. Most frequent EMD sites involved were pulmonary (30%), soft tissue (21%), cerebrospinal fluid (23%), renal (8%), and bone (9%). The median overall survival at 10 years was 79% (95% CI: 57-90%). This is the first study to describe the clinical characteristics, response and overall survival in patients with extramedullary WM. Further studies to define the molecular characteristics of this entity and mechanisms of its development are warranted.
Stabilization of Antigens on Surfaces of Malignant Cells by Formalin Treatment2
Authors: Toshio Kudo, Tadao Aoki, Janice L. Morrison
Journal: JNCI Journal of the National Cancer Institute (1974)

Journal Article Stabilization of Antigens on Surfaces of Malignant Cells by Formalin Treatment Get access Toshio Kudo, Toshio Kudo 3Immunology Section, Viral Leukemia and Lymphoma Branch, National Cancer Institute, National Institutes of Health, U.S. Public Health Service, Department of Health, Education, and Welfare, Bethesda, Md. 20014 Search for other works by this author on: Oxford Academic PubMed Google Scholar Tadao Aoki, Tadao Aoki 3Immunology Section, Viral Leukemia and Lymphoma Branch, National Cancer Institute, National Institutes of Health, U.S. Public Health Service, Department of Health, Education, and Welfare, Bethesda, Md. 20014 Search for other works by this author on: Oxford Academic PubMed Google Scholar Janice L. Morrison Janice L. Morrison 4Meloy Laboratories, Springfield, Va Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 52, Issue 5, May 1974, Pages 1553–1557, https://doi.org/10.1093/jnci/52.5.1553 Published: 01 May 1974 Article history Received: 02 November 1973 Accepted: 16 January 1974 Published: 01 May 1974
Sequence Type ST131 and ST10 Complex (ST617) predominant among CTX-M-15-producing Escherichia coli isolates from Nigeria* *This study has been partially presented during the 51st Interscience Conference on Antimicrobial Agents and Chemotherapy (ICAAC) in Chicago, IL, September 2011.
Authors: I. Aibinu, T. Odugbemi, W. Koenig, B. Ghebremedhin
Journal: Clinical Microbiology and Infection (2011)
In adult smokers in the ED, a multicomponent intervention increased smoking cessation at 3 months
Authors: Eddy Lang
Journal: Annals of Internal Medicine (2015)

Source Citation Bernstein SL, D’Onofrio G, Rosner J, et al.Successful tobacco dependence treatment in low-income emergency department patients: a randomized trial. Ann Emerg Med. 2015;66:140-7. 25920384
Exploring Statins to Decrease HIV-Related Heart Disease Risk
Authors: Mike Mitka
Journal: JAMA (2015)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Liver resectability following S-1+L-OHP with cetuximab as the first-line treatment of unresectable liver limited metastases from KRAS exon 2 wild-colorectal cancer in Japanese patients (KSCC 1002).
Authors: Yuji Miyamoto, Yasunori Emi, Shoji Tokunaga, Toru Beppu, Yoshihiro Kakeji, Eiji Oki, Hiroshi Saeki, Shinichiro Mori, Masafumi Inomata, Yoshito Akagi, Hideo Baba, Shoji Natsugoe, Yutaka Ogata, Yoshihiko Maehara
Journal: Journal of Clinical Oncology (2015)

755 Background: There is no data concerning liver resectability following S-1+L-OHP (C-SOX) with cetuximab (Cmab) as the first-line treatment of unresectable liver limited metastases from KRAS exon 2 wild-colorectal cancer by prospective, multi-center study in Japan. The Kyushu Study group of Clinical Cancer (KSCC) conducted phase II trials in this setting. Methods: Eligibility criteria included unresectable liver limited metastases from histologically confirmed advanced colorectal cancer, ECOG PS 0-1 and adequate general condition. Patients (pts) received 4-6 cycles of C-SOX (oxaliplatin 130 mg/m 2 , day 1 followed by S-1 80 mg/m2 po [days 1-14] every 3 weeks) with weekly durable intravenous (DIV) Cmab administration at 400 mg/m 2 (day 1) and 250 mg/m 2 /week (except day 1), followed by evaluating the liver resectability. Results: Of the 33 pts enrolled from March 2010 to July 2013; M/F, 20/13; median age, 64 years (range 48-83); ECOG PS 0/1, 27/6; primary lesion -/+, 18/15; number of liver metastasis 1-4/5 or more, 10/23; uni-/bi-lobular liver meta. 5/28; synchronous/metachronous 30/3. The number of FAS and SAS cases was 33. Response without confirmation for CR, PR, SD, PD and NE were 1 (3.0%), 20 (60.6%), 6 (18.2%), 3 (9.1%) and 3 (9.1%), respectively. An overall response rate was 63.6% (95% CI: 46.3–81.0%). The liver resectability for all time treatment was 16/33 (48.5%). The number of R0 cases was 13 pts (39.4%). Median progression free survival (liver resection was not censored and not event, events = relapse, progression, secondary cancer, and death) for 16 liver resection cases and 17 not-resection cases were 25.0 months (8.1-not reached), 4.5 months (3.0-10.8), respectively. Median overall survival (mOS) for all 33cases was 31.6 months (14.8, not reached). Median OS for 17 not-resection cases was 14.0 (6.4-not reached), and mOS for 16 liver resection cases was not reached and 3-year survival rate was 51.4%. Conclusions: C-SOX + Cmab regimen is safe and effective for unresectable liver limited metastases from KRAS exon 2 wild-colorectal cancer, and might be to lead the high liver resectability. Clinical trial information: UMIN000004331.
Flavopiridol Induces Apoptosis of Normal Lymphoid Cells, Causes Immunosuppression, and Has Potent Antitumor Activity In Vivo Against Human Leukemia and Lymphoma Xenografts
Authors: Francisco Arguello, Mark Alexander, Judith A. Sterry, Gabriela Tudor, Erik M. Smith, Naina T. Kalavar, John F. Greene, William Koss, C. David Morgan, Sherman F. Stinson, Timothy J. Siford, W. Gregory Alvord, Richard L. Klabansky, Edward A. Sausville
Journal: Blood (1998)
Gas Exchange in Abdominal Cavity during Laparoscopy
Authors: A E Cameron, G L de Dear, T J Pocock, R W G Tennant
Journal: Journal of the Royal Society of Medicine (1983)

Gas exchange occurring in the abdominal cavity during laparoscopy, using carbon dioxide as the insufflating gas, was investigated in 25 female patients being ventilated with 66.6% nitrous oxide and 33.3% oxygen. The gas remaining in the abdomen at the end of the procedure was collected and measurements were made using an infrared spectrometer, a paramagnetic analyser and a mass spectrometer. The mean duration of the laparoscopy was 9.5 minutes and the mean volume of carbon dioxide delivered was 6.8 litres. Nitrous oxide concentration in the abdomen was found to increase significantly with the duration of the procedure, varying from 1.4% to 12.8% with a mean of 4.3% (s.d. +/- 2.4). Oxygen concentration measured from 0.1 to 1.8% with a mean of 0.7% (s.d. +/- 0.4). Nitrogen concentration varied from zero to 1.8%, having a mean concentration of 0.8% (s.d. +/- 0.5). Carbon dioxide content was from 85.7 to 99.6% with a mean concentration of 94.2% (s.d. +/- 3.1).
Salmonella genomic island 1-J variants associated with change in the antibiotic resistance gene cluster in multidrug-resistant Salmonella enterica serovar Virchow isolated from humans, Taiwan, 2004–2006
Authors: C. Chu, B. Doublet, Y.-L. Lee, A. Cloeckaert, C.-S. Chiou, S.-W. Chen, C.-W. Lin, C.-H. Chiu
Journal: Clinical Microbiology and Infection (2011)
IL-17A induces glucocorticoid insensitivity in airway epithelial cells
Authors: Jan Zijlstra, Nick ten Hacken, Roland Hoffmann, Antoon van Oosterhout, Irene Heijink
Journal: European Respiratory Journal (2011)

Glucocorticoids (GC) are the cornerstone of asthma treatment. However, a subset of asthma patients is insensitive, which is a problem in the management of asthma. Previous studies suggest that GC-insensitivity is associated with Th17 cells. Th17 cells act by producing inflammatory cytokines, including IL-17A. We aimed to assess whether IL-17A reduces GC sensitivity in airway epithelial cells and to elucidate the underlying mechanism.  We investigated the effect of IL-17A on the suppressive effect of budesonide (BUD) (10 -10 -10 -9 M) on TNF-α-induced IL-8 secretion and on Histone Deacetylase (HDAC) activity in the human bronchial epithelial cell line 16HBE with/without specific inhibitors for the ERK, p38 and PI3K pathways and upon overexpression of HDAC2.  We observed that IL-17A-induced IL-8 secretion is normally sensitive to GC in 16HBE, in contrast pre-treatment with IL-17A (2h) significantly reduces the sensitivity of TNF-α-induced IL-8 secretion to BUD. Immunodetection revealed that IL-17A activates the p38, ERK and PI3K pathways, but only inhibition of PI3K signaling reversed this GC-insensitivity. Our data suggest that IL-17A-induced GC-insensitivity is mediated by a reduction in HDAC2 activity, as IL-17A reduced HDAC activity, while overexpression of HDAC2 reversed IL-17A-induced GC-insensitivity. In contrast, IL-17A did not affect BUD-induced transcriptional activity, suggesting that IL-17A does not impair translocation of the ligated GC receptor.  In conclusion, we show that IL-17A induces GC-insensitivity in bronchial epithelium which likely involves PI3K-dependent reduction in HDAC2 activity. IL-17A-induced PI3K signaling may thus serve as a new target for therapeutic intervention in GC-insensitive asthma.
Protease-antiprotease imbalance in airway secretions in subjects with acute respiratory failure
Authors: Jennifer Acevedo, Maria Srinivasan, Mario Ponce, Samuel Rosero, Adriana Amelinckx, Philip Whitney, Michael Campos
Journal: European Respiratory Journal (2012)

Studies have shown that in the acute respiratory distress syndrome (ARDS) there is protease-antiprotease imbalance, reflected as an increase in the ratio of Human Neutrophil Elastase (HNE) to several protease inhibitors in BAL and plasma. This imbalance can be related to the pathophysiology of ARDS and may correlate with clinical outcomes. The purpose of the study was to determine if similar protease-antiprotease imbalance could be detected in airway secretions in subjects at risk of developing ARDS.  Free HNE activity (HNEA) and levels of the protease inhibitors alpha-1 antitrypsin (AAT) and secretory leukocyte protease inhibitor (SLPI) were measured in samples of endotracheal aspirates samples collected serially in subjects intubated because of acute respiratory failure in a medical ICU (n=42 subjects, 10 eventually developed ARDS).  Contrary to reports studying BAL, we observed that free elastase activity is reduced in airway secretions of subjects that develop ARDS compared to subjects that did not. No differences were noted in AAT and SLPI concentrations in airway secretions among these groups. HNEA/AAT and HNEA/SLPI ratios were reduced in 19 subjects. In ARDS subjects, levels of HNEA returned to normal the first day after the onset of ARDS. There were no differences in survival between subjects who had detectable free HNEA compared with those that did not.  Analysis of protease-antiprotease balance in airway secretions of subjects with acute respiratory failure is not useful to discriminate subjects who develop ARDS and does not correlate with survival.
The Role of Chest Radiography in Patients Presenting with Anterior Chest Pain to the Accident &amp; Emergency Department
Authors: N J Russell, C F A Pantin, P A Emerson, N J Crichton
Journal: Journal of the Royal Society of Medicine (1988)

The chest radiological findings and outcomes of 120 consecutive patients attending the Accident &amp; Emergency Department with anterior chest pain were recorded prospectively to investigate the value of routine chest radiography in their management. Twenty-one patients (17.5%) were excluded because of incomplete information. Thirty-seven radiological abnormalities were identified in 33 (33%) of the remaining 99 chest X-rays. Seventeen of the abnormalities identified in 14 (14%) of the chest X-rays were clinically significant. The casualty officer's interpretation of 70 (70%) of the chest X-rays was correct, but 36 errors were made interpreting the other 29 chest X-rays. Of these errors, 19 were false negative errors, resulting in the mismanagement of two patients and 17 false positive errors, resulting in the mismanagement of four patients. It appears that a routine chest X-ray provides little information of practical value in the management of patients with anterior chest pain attending an Accident &amp; Emergency Department, unless the training of medical students and junior doctors in the interpretation of chest X-rays is improved.
Immunological mechanisms of sublingual allergen-specific immunotherapy
Authors: N. Novak, T. Bieber, J.-P. Allam
Journal: Allergy (2011)

To cite this article: Novak N, Bieber T, Allam J-P. Immunological mechanisms of sublingual allergen-specific immunotherapy. Allergy 2011; 66: 733–739. Within the last 100 years of allergen-specific immunotherapy, many clinical and scientific efforts have been made to establish alternative noninvasive allergen application strategies. Thus, intra-oral allergen delivery to the sublingual mucosa has been proven to be safe and effective. As a consequence, to date, sublingual immunotherapy (SLIT) is widely accepted by most allergists as an alternative to conventional subcutaneous immunotherapy. Although immunological mechanisms remain to be elucidated in detail, several studies in mice and humans within recent years provided deeper insights into local as well as systemic immunological features in response to SLIT. First of all, it was shown that the target organ, the oral mucosa, harbours a sophisticated immunological network as an important prerequisite for SLIT, which contains among other cells, local antigen-presenting cells (APC), such as dendritic cells (DCs), with a constitutive disposition to enforce tolerogenic mechanisms. Further on, basic research on local DCs within the oral mucosa gave rise to possible alternative strategies to deliver the allergens to other mucosal regions than sublingual tissue, such as the vestibulum oris. Moreover, characterization of oral DCs led to the identification of target structures for both allergens as well as adjuvants, which could be applied during SLIT. Altogether, SLIT came a long way since its very beginning in the last century and some, but not all questions about SLIT could be answered so far. However, recent research efforts as well as clinical approaches paved the way for another exciting 100 years of SLIT.