tbuckley/cabot-search huggingface dataset:
The metropolitan acid aerosol characterization study: results from the summer 1994 Washington, D.C. field study.
Authors: H H Suh, Y Nishioka, G A Allen, P Koutrakis, R M Burton
Journal: Environmental Health Perspectives (1997)

An ambient particle monitoring study was conducted in Washington, D.C. during the summer of 1994 as part of the Metropolitan Acid Aerosol Characterization Study (MAACS). Acid aerosol and inhalable (particulate matter with aerodynamic diameters < 10 micron; PM10) and fine (particulate matter with aerodynamic diameters < 2.5 micron; PM2.5) particle samples were collected for 24-hr periods (9 A.M.-9 A.M. EDT) on alternate days at six monitoring sites located throughout the greater Washington, D.C. area. Monitoring sites were located in both urban and rural areas and were generally situated along a southwest to northeast line due to the prevailing winds. Information on site characteristics, including population density and distance from the city center, was also obtained, as were data on meteorological parameters. Results from this study show strong correlations among the particulate measures, PM10, PM2.5, SO4(2-), and H+. These strong correlations resulted from the fact that PM2.5 comprised 77% of PM10, with SO4(2-)-related species accounting for 49% of total PM2.5. PM10, PM2.5, SO4(2-), and H+ concentrations were found to be uniform across the metropolitan Washington area. Spatial variation was found, however, for coarse particles (PM2.5-10) and NH3 concentrations. In our previous Philadelphia study, population density was an important determinant of spatial variation in coarse particles and NH3 concentrations, however, in Washington, D.C., population density was not associated with observed spatial patterns in coarse particle concentrations, but was an important determinant of NH3 concentrations. When data from one site (Reservoir) was excluded from the analysis, population density explained larger percentage of the variability in NH3 levels and became an important determinant of the H+/SO4(2-) ratio as well. Ambient H+ models developed from Philadelphia data were found to predict H+ concentrations in Washington, D.C. reasonably well, representing an improvement over measurements made at a single stationary ambient monitoring site.
Ibrutinib-induced lymphocytosis in patients with chronic lymphocytic leukemia: correlative analyses from a phase II study
Authors: S E M Herman, C U Niemann, M Farooqui, J Jones, R Z Mustafa, A Lipsky, N Saba, S Martyr, S Soto, J Valdez, J A Gyamfi, I Maric, K R Calvo, L B Pedersen, C H Geisler, D Liu, G E Marti, G Aue, A Wiestner
Journal: Leukemia (2014)
25 INTRAHEPATIC HHV6 DNA LEVELS BUT NOT EBV OR CMV ARE ASSOCIATED WITH GRAFT SURVIVAL AFTER LIVER TRANSPLANTATION
Authors: S. Pischke, J. Goesling, I. Engelmann, B. Woelk, J. Schlue, T. Becker, T. Schulz, C.P. Strassburg, M.P. Manns, H. Wedemeyer, A. Heim
Journal: Journal of Hepatology (2010)
Psychiatric Manifestations From Insecticide Exposure
Authors: Robert F. Mobbs
Journal: JAMA (1972)

<h3>To the Editor.—</h3> Graybill and his collaborators reported an epidemic of 221 cases of neuromyasthenia, primarily among hospital personnel, at the Lackland Air Force Base in Texas (219:1440, 1972). The syndrome was characterized chiefly by acute gastroenteritis, myalgias, and lethargy, among numerous other symptoms, and in 18 of the cases, encephalopathy. Extensive and obviously very careful epidemiologic studies failed to elicit a cause, despite consideration of possible bacteriologic, viral, or toxic etiology. The syndrome is reminiscent of one we have encountered many times in the course of more than two decades of investigation, in persons exposed to chlorinated cyclic hydrocarbon, organic phosphorus, or carbamate insecticides, used in and about hospitals, schools, apartment buildings, homes, and other structures. There is no indication in the paper by Graybill and associates that possible exposure to insecticides was considered in the search for an etiologic agent. Hospitals especially are routinely treated by exterminators at
Endoscopic diagnosis of pharyngeal carcinoma by NBI
Authors: S. Nonaka, Y. Saito
Journal: Endoscopy (2008)

Head and neck cancer, especially pharyngeal cancer, frequently co-exist with esophageal cancer, but pharyngeal cancer has proven difficult to detect in such cases before its progression to an advanced stage. Several recent reports have indicated that narrow-band imaging (NBI) endoscopy with magnification is able to improve the detection of superficial pharyngeal cancer. NBI is a relatively new optical technology based on limiting the depth of light penetration into the mucosa. The recognition of these lesions is dramatically improved and the microvascular structure of the mucosal surface is significantly enhanced by NBI. As a result, NBI enables more accurate diagnosis and increases the detection rate of superficial pharyngeal cancer. This particular field has only been developed in recent years, however, and there are still a number of problems that need to be addressed in the future. It will be necessary to accumulate and evaluate resected specimens and follow up patients in order to establish the appropriate criteria for curative endoscopic treatment in these patients. The ease in using NBI in combination with this new diagnostic concept based on microvascular changes makes NBI suitable for worldwide use in the future.
Abstract 2184: Analysis of human polynucleotide phosphorylase function in human melanoma
Authors: Upneet K. Sokhi
Journal: Cancer Research (2012)

Abstract Human polynucleotide phosphorylase (hPNPaseold-35) is an evolutionarily conserved 3′, 5′ exoribonuclease predominantly involved in mRNA degradation. It is a type I IFN-inducible early response gene that was identified as a gene upregulated in terminally differentiated and senescent fibroblasts. Overexpression of hPNPaseold-35 via a replication incompetent adenovirus (Ad.hPNPaseold-35) arrests multiple cancer cell types in the G1 phase of the cell cycle, with cells eventually undergoing apoptosis. A potential mechanism of this growth inhibition and eventual apoptosis induction is the ability of hPNPaseold-35 to selectively degrade c-myc mRNA. This was further proven by the overexpression of c-myc that partially but significantly protects human melanoma cells from Ad.hPNPaseold-35-mediated growth inhibition, indicating that c-myc down-regulation might directly mediate the growth-inhibitory properties of Ad.hPNPaseold-35. Since the protection offered by c-myc overexpression was incomplete, additional targets of hPNPaseold-35 are likely to exist that may play a role in mediating its growth-inhibitory effects. The goal of the present study was to identify these additional candidate genes that may be directly or indirectly regulated by hPNPaseold-35, which would help us better understand the physiological implications of this interesting enzymatic protein. In order to identify the target genes a whole genome cDNA microarray was performed to assess gene expression changes that occur when hPNPaseold-35 was silenced in HO-1 melanoma cells. The genes that are upregulated in the hPNPaseold-35 knockdown cell line might be potential direct degradation targets of hPNPaseold-35 according to our current hypothesis. Finally, validation of these targets may provide us a unique opportunity for defining specific molecules and pathways that may represent new targets of hPNPaseold-35 contributing to its growth-inhibitory effects, which may be further used for developing approaches to enhance its therapeutic efficacy. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 103rd Annual Meeting of the American Association for Cancer Research; 2012 Mar 31-Apr 4; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2012;72(8 Suppl):Abstract nr 2184. doi:1538-7445.AM2012-2184
A Tablet Test for Blood in Urine
Authors: E. J. Watson-Williams
Journal: BMJ (1955)

<b>Objective:</b> To investigate the prevalence and distribution of gadolinium (Gd) enhancement at cardiac magnetic resonance (CMR) imaging in patients with cardiac amyloidosis (CA) and to look for associations with clinical, morphological, and functional features. <b>Patients and design:</b> 21 patients with definitely diagnosed CA (nine with immunoglobulin light chain amyloidosis and 12 transthyretin related) underwent Gd-CMR. <b>Results:</b> Gd enhancement was detected in 16 of 21 (76%) patients. Sixty six of 357 (18%) segments were enhanced, more often at the mid ventricular level. Transmural extension of enhancement within each patient significantly correlated with left ventricular (LV) end systolic volume (<i>r</i> = 0.58). The number of enhanced segments correlated with LV end diastolic volume (<i>r</i> = 0.76), end systolic volume (<i>r</i> = 0.6), and left atrial size (<i>r</i> = 0.56). Segments with &gt; 50% extensive transmural enhancement more often were severely hypokinetic or akinetic (p = 0.001). Patients with &gt; 2 enhanced segments had significantly lower 12 lead QRS voltage and Sokolow-Lyon index. No relation was apparent with any other clinical, morphological, functional, or histological characteristics. <b>Conclusion:</b> Gd enhancement is common but not universally present in CA, probably due to expansion of infiltrated interstitium. The segmental and transmural distribution of the enhancement is highly variable, and mid-ventricular regions are more often involved. Enhancement appears to be associated with impaired segmental and global contractility and a larger atrium.
The Human Molecular Genetics Network
Authors: Carlo Gambacorti-Passerini, Jurg Ott, Arthur Bergen
Journal: New England Journal of Medicine (1995)

To the Editor: Tugwell et al. ( July 20 issue) 1 found that "patients with severe rheumatoid arthritis and only partial responses to methotrexate had clinically important improvement after combination therapy with cyclosporine and methotrexate."We are concerned about the manner in which the cyclosporine doses were adjusted.No mention of the patients' serum cyclosporine levels was made.Determination of serum cyclosporine levels might have allowed a better understanding of the results with respect to therapeutic serum ranges of this medication.The authors state that people with rheumatoid arthritis "have a risk of cancer 20 to 30 times higher than people in general."Cash and Klippel 2 concluded in a 1995 review that patients with rheumatoid arthritis are not at increased risk of cancer overall, although the rates of selected cancers, such as hematologic cancers, especially multiple myeloma and non-Hodgkin's lymphoma, appear to be increased.
Updated Systematic Review and Meta-Analysis of the Comparative Data on Colposuspensions, Pubovaginal Slings, and Midurethral Tapes in the Surgical Treatment of Female Stress Urinary Incontinence
Authors: Giacomo Novara, Walter Artibani, Matthew D. Barber, Christopher R. Chapple, Elisabetta Costantini, Vincenzo Ficarra, Paul Hilton, Carl G. Nilsson, David Waltregny
Journal: European Urology (2010)
Botulinum toxin abolishes sweating via impaired sweat gland responsiveness to exogenous acetylcholine
Authors: M. Shibasaki, S.L. Davis, J. Cui, D.A. Low, D.M. Keller, C.G. Crandall
Journal: British Journal of Dermatology (2009)

Botulinum toxin A (BTX) disrupts neurotransmitter release from cholinergic nerves. The effective duration of impaired sweat secretion with BTX is longer relative to that of impaired muscle contraction, suggesting different mechanisms in these tissues.The aim of this study was to test the hypothesis that BTX is capable of altering sweating by reducing the responsiveness of the sweat gland to acetylcholine.BTX was injected into the dorsal forearm skin of healthy subjects at least 3 days before subsequent assessment. On the day of the experiment, intradermal microdialysis probes were placed within the BTX-treated area and in an adjacent untreated area. Incremental doses of acetylcholine were administered through the microdialysis membranes while the sweat rate (protocol 1; n = 8) or a combination of sweat rate and skin blood flow (protocol 2; n = 8) were assessed.A relative absence of sweating was observed at the BTX site for both protocols (protocol 1: 0.05 +/- 0.09 mg cm(-2) min(-1); protocol 2: 0.03 +/- 0.04 mg cm(-2) min(-1), both at the highest dose of acetylcholine), while the sweat rate increased appropriately at the control sites (protocol 1: 0.90 +/- 0.46 mg cm(-2) min(-1); protocol 2: 1.07 +/- 0.67 mg cm(-2) min(-1)). Cutaneous vascular conductance increased to a similar level at both the BTX and control sites.These results demonstrate that BTX is capable of inhibiting sweat secretion by reducing the responsiveness of the sweat gland to acetylcholine, while not altering acetylcholine-mediated cutaneous vasodilatation.
Is gliadin really safe for non-coeliac individuals? Production of interleukin 15 in biopsy culture from non-coeliac individuals challenged with gliadin peptides
Authors: D Bernardo, J A Garrote, L Fernandez-Salazar, S Riestra, E Arranz
Journal: Gut (2007)

anti-CD-WPC, and should be confirmed in a prospective placebo-controlled randomised trial.
Risk of Tuberculosis in Pregnancy
Authors: Dominik Zenner, Michelle E. Kruijshaar, Nick Andrews, Ibrahim Abubakar
Journal: American Journal of Respiratory and Critical Care Medicine (2011)

Tuberculosis (TB) disease adversely affects mother and child, and strategies to control TB in this group are important. The aim of this study was to analyze the epidemiology of TB in pregnancy, and to establish whether pregnancy is an independent risk factor for TB.The United Kingdom-wide cohort study was based on the General Practitioner Research Database (GPRD), enrolling all women with pregnancies between 1996 and 2008. Incidence rates and incidence rate ratios (IRRs) of TB events during pregnancy, 6 months postpartum, and outside pregnancy were calculated and compared by Poisson regression. A nested self-controlled case series compared the risk of TB in these periods, adjusting for individual and time-bound confounders.The crude TB rate for the combined pregnancy and postpartum period was 15.4 per 100,000 person-years, significantly higher than outside of pregnancy (9.1 per 100,000 person-years; P = 0.02). Adjusting for age, region, and socioeconomic status the postpartum TB risk was significantly higher than outside pregnancy (IRR, 1.95; 95% confidence interval [CI], 1.24-3.07), whereas there was no significant increase during pregnancy (IRR, 1.29; 95% CI, 0.82-2.03). These observations were confirmed in the self-controlled case series (IRR, 1.62; 95% CI, 1.01-2.58 and IRR, 1.03; 95% CI, 0.64-1.65, respectively).The incidence of TB diagnosis is significantly increased postpartum. Although we did not find an increase during pregnancy, the postpartum incidence may reflect an increase during pregnancy given diagnostic, immunological and administrative delays. Clinicians' awareness should be improved and the effectiveness of public health policy measures such as targeted screening of pregnant and postpartum women in high-risk groups should be evaluated.
Interventional Therapy for Coronary Artery Disease
Authors: Pinak B. Shah, Craig M. Lilly
Journal: American Journal of Respiratory and Critical Care Medicine (2002)

generation stents have been associated with restenosis rates of Since the introduction of percutaneous coronary intervention in approximately 15% in selected patient populations. the 1970s, its use has increased dramatically. An estimated The United States Food and Drug Administration initially 650,000 patients underwent percutaneous coronary intervention approved stents for use in emergency situations when balloon in 1999 (1), and the American College of Cardiology and the angioplasty was complicated by severe dissection or abrupt vesAmerican Heart Association guidelines now designate the qualsel closure. Currently, however, coronary stents are used as firstity of the evidence of benefit for high-risk patients as 1A. Balloon line treatment in as many as 80% of percutaneous coronary angioplasty allows for minimally invasive treatment of coronary interventions. The one lesion subset for which coronary stents artery disease but has limitations when used alone. These limitahave not been convincingly shown to improve on balloon angiotions include abrupt vessel closure (caused by vessel recoil or plasty is diseased vessels with diameters of less than 2.5 mm (4). persistent intimal dissection) in up to 5% of patients and restenoThese lesions are often treated with balloon angioplasty alone. sis requiring repeat angioplasty or coronary artery bypass sur-
Androgen receptor dysfunction in human androgen insensitivity
Authors: Terry R. Brown
Journal: Trends in Endocrinology and Metabolism (1995)

The androgen insensitivity syndromes comprise a spectrum of phenotypic abnormalities in male sex differentiation and development that result from target tissue resistance to androgen action due to molecular lesions in the X-chromosome-linked androgen receptor gene. The androgen receptor, like other members of the superfamily of steroid receptors, is characterized by the presence of three structural domains that function in transcriptional activation, DNA binding, and steroid binding, respectively. Missense mutations in the androgen receptor gene causing amino acid substitutions are the most common molecular lesions among affected subjects; deletions, mRNA splice site alterations, and nonsense mutations occur less frequently. Because of the large number and diverse array of these naturally occurring mutations and their associated clinical phenotypes, there is a great opportunity for understanding the structure-function relationships of the androgen receptor from in vitro and in vivo expression of the mutant receptors in various cell types.
Letter: Mid-trimester termination.
Authors: S M Karim, S S Ratnam
Journal: BMJ (1974)

This letter comments on a previously published article (August 17, p. 428) relating to the use of prostaglandins for midtrimester abortion. It is estimated that prostaglandin PGF-2-alpha given by the i ntrauterine route has been used in over 5000 patients; 13 cases of cervi cal rupture have been reported. Most ruptrues have occurred in primigravidae. All but 1 of them (who received PGE-2) were given PGF-2-alpha intraamniotically. Periods of gestation have been 15-22 weeks. Large doses of prostaglandins have been used and often supplemented by other oxytocics such as urea or oxytocin. No reported cervical ruptures have followed use of PGE-2 alone, possibly because of its relaxant effect on the cervix. Previous gradual dilatation of the cervix with laminaria tents or with some synthetic prostaglandin analogue is being studied. In first trimester pregnancies prostaglandin analogues given as a single extraamniotic dose 12 or more hours prior to termination has been shown to effect gradual dilatation of the cervix. Of 88 such cases, only 3 required mechanical dilatation of the cervix. It is felt that prostaglandins offer an attractive alternative to hysterotomy or hypertonic saline for terminating second trimester pregnancies when overstimulation of the uterus by large doses is avoided.
Henoch-Schonlein purpura associated with Legionnaires' disease.
Authors: P W Bull, J T Scott, S M Breathnach
Journal: BMJ (1987)

morbidity in patients with acute medical conditions.24Patients with psychiatric morbidity have a poorer outcome in terms of social adaptability and also further mortality and morbidity.'The ratio of men to women in this study was 3:1, with 29% (14/48) of the patients with depression and 23% (14/60) of those without depression being women.Strikingly, 14 of the 16 patients who had a poor outcome were men (p<000l).Relation between score on Montgomery-Asberg rating scale and good and poor outcome Score on rating scale Outcome < 14 -14 Total Good 58 34 92 Poor 2 14 16 Total 60 48 108Clearly, depression in men in the first 24 hours after myocardial infarction represents a considerably increased risk of early death, reinfarction, or myocardial arrest, and therefore these patients should be closely monitored for longer than is at present routine.I thank Dr J P H Davies, consultant cardiologist, for his support and encouragement in this study and Dr E M Phillips and Dr P Jenkins for allowing me to use their patients.
Temporal Changes In Lung Function In A Mouse Worker Population
Authors: B.M. Thomas, C. Aloe, J. Curtin-Brosnan, R.D. Peng, P.A. Eggleston, W.G. Shreffler, K.A. Hagberg, M. Krevans, R. Korstanje, E.C. Matsui
Journal: Journal of Allergy and Clinical Immunology (2012)
Contractility, Metabolism and Pharmacological Reactions of Isolated Gas-Perfused Cat Hearts
Authors: LLOYD P. GABEL, IVAN BIHLER, PETER E. DRESEL
Journal: Circulation Research (1966)

Cat hearts were perfused through the aorta with substrate-free Krebs solution for 5 min, then with 5% CO 2 -95% O 2 saturated with water vapor at 37.5°C. Heart rate decreased rapidly but contractility was maintained at pre-gas levels for 3 to 4 hours, decreasing to 25% at 10 hours. Driving the preparations at 168 beats/min did not appreciably change the time course of change in contractility. The hearts developed more tension at all resting tensions and were able to perform more work than hearts perfused with substrate-free Krebs solution, but their work capacity was less than that of hearts perfused with glucose-Krebs solution. They reacted normally to sympathomimetic amines and blocking agents. They were very sensitive to increases in perfusion pressure, developing completely reversible arrhythmias at pressures 80 to 150% above the control (60 mm Hg). Most hearts developed contractile alternans which usually was not accompanied by electrical alternation. Glycogen, lactate, pyruvate content decreased rapidly, the first to a residual level and the others to undetectable levels.
Vascular Endothelial Cell Antibodies in Diabetic Patients: Association With Diabetic Retinopathy
Authors: David B Jones, Robert Wallace, Brian M Frier
Journal: Diabetes Care (1992)

Objectives To determine the incidence of antiendothelial cell antibodies in diabetic patients with and without retinopathy. Research Design and Methods The study consisted of 70 insulin-dependent diabetic (IDDM) subjects, 36 non-insulin-dependent diabetic (NIDDM) subjects, and 40 nondiabetic control subjects. Blood samples were obtained from diabetic patients and control subjects and patients with background and proliferative retinopathy were identified. Results Vascular endothelial cell (VEC) antibodies were examined in the sera of 36 NIDDM subjects, 70 IDDM subjects, and 40 nondiabetic control subjects by indirect immunofluorescence. VEC antibodies were present in 5 of 40 (12%) control subjects, 7 of 23 (30%) newly diagnosed IDDM patients, 6 of 17 (35%) IDDM patients without retinopathy, 12 of 18 (67%) IDDM patients with background retinopathy (P &amp;lt;0.05), and 9 of 12 (75%) IDDM patients with proliferative retinopathy (P &amp;lt;0.01). Three of 13 (23%) NIDDM patients with retinopathy and 6 of 23 (26%) without retinopathy were VEC antibody positive. No associations were observed between the presence of VEC antibodies and either the quality of glycemic control or the duration of diabetes. A significant association between VEC antibodies and large-vessel disease was found in IDDM patients with retinopathy (P &amp;lt;0.05). Conclusions Antibodies directed against vascular endothelial cells may play a role in the development of microvascular, and possibly macrovascular, disease in diabetes.
Renal Failure from Vitamin C after Transplantation
Authors: Brian J Nankivell, Karumathil M Murali
Journal: New England Journal of Medicine (2008)

In this 31-year-old woman, oliguric renal allograft failure developed from widespread deposition of calcium oxalate crystals. She had a history of self-medication with vitamin C (2 g per day) while on dialysis.