PARENTERAL ADMINISTRATION OF AMMIVIN (KHELLIN) IN THE TREATMENT OF CORONARY DISEASE
Authors: E E KLEIBER
Journal: Annals of Internal Medicine (1952)

Article1 May 1952PARENTERAL ADMINISTRATION OF AMMIVIN (KHELLIN) IN THE TREATMENT OF CORONARY DISEASEESTELLE E. KLEIBER, M.D., F.A.C.P.ESTELLE E. KLEIBER, M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-36-5-1179 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptIn recent years there has appeared on the market a drug named khellin, C14H12O5, the active principle from a native Egyptian plant,Ammi visnaga, known since ancient times as an antispasmotic. This drug has been found to be a coronary vasodilator, with apparent potency about four times that of aminophylline. It is available for oral use in doses of 20 to 50 mg. in an enteric coated tablet. An abundant literature has appeared on the oral use of this drug.1-5However, many of these studies, while suggesting a good effect in the control of angina, report a high...Bibliography1. BestCoe MMWS: Effect of khellin on coronary artery insufficiency as evaluated by electrocardiographic tests, Circulation 2: 344, 1950. CrossrefMedlineGoogle Scholar2. AnrepKenawyBarsoum GVMRGS: The coronary vasodilatory action of khellin, Am. Heart J. 37: 531, 1949. CrossrefMedlineGoogle Scholar3. DewarGrimson HATA: Khellin in the treatment of angina of effort, Brit. Heart J. 12: 54, 1950. CrossrefMedlineGoogle Scholar4. ArmbrustLevine CASA: The treatment of angina pectoris with a preparation of khellin (Ammi visnaga), Am. J. M. Sc. 220: 127, 1950. CrossrefMedlineGoogle Scholar5. ScottIglauerGreenKaufmanBermanMcGuire RCARSJWBJ: Studies on the effect of oral and parenteral administration of visammin (khellin) in patients with angina pectoris, Circulation 3: 80, 1951. CrossrefMedlineGoogle Scholar6. BarsoumKenawyEl-Sheehy GSMRA: Absorption of khellin and its estimation in blood and tissues, J. Roy. Egyptian M. A. 30: 312, 1947. MedlineGoogle Scholar7. Ayad H: Khellin in angina pectoris, Lancet 1: 305, 1948. CrossrefGoogle Scholar8. RosenmanFishmanKaplanLevinKatz RHAPSRHGKH: Observations on the clinical use of visammin (khellin), J. A. M. A. 143: 160, 1950. CrossrefMedlineGoogle Scholar9. GreinerGoldCattellTravellBakstRinzlerBenjaminWarshawBobbKwitModellRothendlerNesseloffKramer THMJHSHZHLJALNTWHHCRML: A method for the evaluation of the effects of drugs on cardiac pain in patients with angina of effort: a study of khellin (visammin), Am. J. Med. 9: 143, 1950. CrossrefMedlineGoogle Scholar10. GreinerGold TH: A method for the evaluation of the effects of drugs on the cardiac pain of angina of effort: a study of khellin, J. Pharmacol. and Exper. Therap. 98: 10, 1950. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: *Received for publication August 29, 1951. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byArrhythmiasBibliographyDie Coronarerkrankungen. Coronarinsuffizienz, Angina pectoris und HerzinfarktDrug evaluation in angina pectoris: Khellin, heparin, PeritrateTreatment of Angina PectorisTHE TREATMENT OF ANGINA PECTORIS WITH KHELLIN*PART IIJAMES J. CONN, M.D., R. W. KISSANE, M.D., F.A.C.P., RUTH A. KOON, M.D., F.A.C.P., THOMAS E. CLARK, M.D. 1 May 1952Volume 36, Issue 5Page: 1179-1189KeywordsAnginaDrug regulationDrugsExerciseNursesVasodilators ePublished: 1 December 2008 Issue Published: 1 May 1952 PDF downloadLoading ...