THE DIAGNOSTIC, PROGNOSTIC AND EPIDEMIOLOGIC SIGNIFICANCE OF SERUM GLUTAMIC OXALOACETIC TRANSAMINASE (SGO-T) ALTERATIONS IN ACUTE HEPATITIS
Authors: G JERVIS, J S LADUE, F WROBLEWSKI
Journal: Annals of Internal Medicine (1956)

Article1 November 1956THE DIAGNOSTIC, PROGNOSTIC AND EPIDEMIOLOGIC SIGNIFICANCE OF SERUM GLUTAMIC OXALOACETIC TRANSAMINASE (SGO-T) ALTERATIONS IN ACUTE HEPATITISFELIX WRÓBLEWSKI, M.D., F.A.C.P., GEORGE JERVIS, M.D., JOHN S. LADUE, M.D., F.A.C.P.FELIX WRÓBLEWSKI, M.D., F.A.C.P.Search for more papers by this author, GEORGE JERVIS, M.D.Search for more papers by this author, JOHN S. LADUE, M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-45-5-782 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptINTRODUCTIONGlutamic oxaloacetic transaminase (GO-T) is widely distributed in animal and human tissues. Its greatest activity has been found in homogenates of heart muscle, skeletal muscle, brain, liver and kidney, the relative activities varying in different species (table 1). This enzyme activity has been found in all animal and human sera tested, and the activities are comparable whether determined chromatographically,1 spectrophotometrically2 or colorimetrically3 (figure 1). It has been demonstrated that serumglutamic oxaloacetic transaminase (SGO-T) activity increases two to 20 times following acute myocardial infarction,4and may rise to 20 to 500 times normal in acute hepatitis due to toxic...Bibliography1. KarmenWróblewskiLaDue AFJD: Transaminase activity in human blood, J. Clin. Investigation 34: 126-133, 1955. CrossrefMedlineGoogle Scholar2. Appendix to ref. 1. Google Scholar3. CabaudLeeperWróblewski PRF: Colorimetric measurement of glutamic oxaloacetic transaminase, Am. J. Clin. Path., in press. Google Scholar4. LaDueWróblewski JDF: The significance of the serum glutamic oxaloacetic transaminase activity following acute myocardial infarction, Circulation 11: 871-877, 1955. CrossrefMedlineGoogle Scholar5. WróblewskiLaDue FJS: Serum glutamic oxaloacetic transaminase activity as an index of liver cell injury: a preliminary report, Ann. Int. Med. 43: 345-360, 1955. LinkGoogle Scholar6. NydickWróblewskiLaDue IFJS: Evidence for increased serum glutamic oxaloacetic transaminase (SGO-T) activity following graded myocardial infarcts in dogs, Circulation 12: 161-168, 1955. CrossrefMedlineGoogle Scholar7. MolanderWróblewskiLaDue DFJS: Serum glutamic oxaloacetic transaminase as an index of hepatocellular integrity, J. Lab. and Clin. Med. 46: 831-839, 1955. MedlineGoogle Scholar8. WróblewskiLaDue FJS: Serum glutamic pyruvic transaminase in hepatic and cardiac disease: a preliminary report, Proc. Soc. Exper. Biol. and Med. 91: 569-571, 1956. CrossrefMedlineGoogle Scholar9. FriendWróblewskiLaDue CFJS: Glutamic oxaloacetic transaminase activity of serum in mice with viral hepatitis, J. Exper. Med. 102: 699-704, 1955. CrossrefMedlineGoogle Scholar10. WróblewskiLaDue FJS: Serum glutamic oxaloacetic aminopherase (transaminase) in hepatitis, J. A. M. A. 160: 1130-1134, 1956. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: *Presented at the Thirty-seventh Annual Session of The American College of Physicians, Los Angeles, California, April 18, 1956.From Sloan-Kettering Institute and the Medical Service of Memorial Center, New York, and Letchworth Village, Thiells, N. Y.Requests for reprints should be addressed to Felix Wróblewski, M.D., Memorial Center for Cancer and Allied Diseases, 444 East Sixty-eighth Street, New York 21, N. Y. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byHistopathology of the liver in heart failureAnti-inflammatory Effect of a Goji Berry Extract (Lycium barbarum) in Rats Subjected to Inflammation by Lipopolysaccharides (LPS)Hypoxic hepatitisHepatitis C virus: Historical perspective and current conceptBiochemical toxicology of argemone oil. IV short-term oral feeding response in ratsTransfusion-Associated Hepatitis B: Past and PresentAugmented hepatic susceptibility to malathion toxicity in rats on low-protein dietsThe role of serum transaminases (SGO-T and SGP-T) and alkaline phosphatases in relation to inorganic phosphorus with respect to mercury poisoning in aphanius dispar Rüpp (teleostei) of the red seaLiver FunctionToxic renal damage: Changes in enzyme levelsLong-term safety studies of a chloroform-containing dentifrice and mouth-rinse in manLactic Dehydrogenase VirusMiscellaneous Enzymes in Human CancerCellular sites of glutamic oxaloacetic transaminase in pig liver by fluorescent antibody methodThe Effect of Defined Physical Exercise in the Early Convalescence of Viral HepatitisEvaluation of extent of metastatic liver disease: A proposed discriminantLiver FunctionMarked elevations of serum glutamic oxalacetic transaminase and lactic dehydrogenase activity in chronic extrahepatic biliary diseaseSerum isocitric dehydrogenase and glutamic dehydrogenase in schistosomiasisEvolution of Clinical Enzyme TestsAnicteric Viral HepatitisTransaminasenTransaminasenDas Verhalten der Transaminasen (GOT, GPT) und Dehydrogenasen (LDH, MDH) im Serum beim CarcinomrezidivDas Verhalten der Fermentaktivit�ten der GOT, GPT, LDH und MDH im Serum in verschiedenen geburtshilflichen und gyn�kologischen SituationenThe Importance of the Measurement of Enzyme Activity in MedicineCARBON TETRACHLORIDE POISONING: A CASE REPORT AND REVIEWRelative HepatotoxicityComportamento di alcune attivita' enzimatiche del siero di sangue nel diabete mellito, con particolare riferimento agli enzimi epatospecificiDas Verhalten der Transaminasen (GOT, GPT) und Dehydrogenasen (LDH, MDH) im Serum nach Cytostaticabchandlung bei CarcinompatientinnenCorrelation Between Histological Findings and Serum Transaminase Values in Chronic Diseases of the LiverStudies of Serum Transaminases in Xeroderma PigmentosumSerum enzymes in disease.XIV. Abnormality of levels of transaminases and glycolytic and oxidative enzymes and of liver functions as related to the extent of metastatic carcinoma of the liverDer Einflu� gyn�kologischer Operationen auf die Transaminasen (GOT, GPT) und Dehydrogenasen (LDH, MDH) im SerumJaundice, hepatomegaly and fever five years after a radical mastectomyReferencesSorbitdehydrogenase und Chininoxydase im Serum klinisch gesunder und leberkranker Hunde*Serum α-hydroxybutyric dehydrogenase (HBD) in myocardial infarctionEffect of Physical Exercise on Some Enzymes in the SerumExperimentelle und klinische Untersuchungen zur Diagnose der Lebererkrankungen des HundesThe Serum Transaminases in Heart and Liver DiseaseBlood Enzymes in Cancer and Other DiseasesSerum enzymes in disease. V. Isocitric dehydrogenase, malic dehydrogenase, and glycolytic enzymes in patients with carcinoma of the breastElevations of Serum Transaminase Activities Following Infectious HepatitisEnzymverteilungsmuster des glykolytischen Systems und Citronens�urecyclus im Plasma KrebskrankerOsservazioni Sul Tasso Serico Di Alcuni Enzimi E Sulle Sue Modificazioni in Rapporto Alla Terapia Radiante, in Pazienti Affetti Da Neoplasie MaligneSerum Enzymes in Bronchogenic Carcinoma and Other Pulmonary DiseasesRheumatoid Arthritis and Hepatocellular InjuryViral Hepatitis: Clinical and Laboratory ManifestationsHepatic effects of chloroform anesthesia in obstetricsDie diagnostische Bedeutung einiger SerumfermenteDe Glutaminezuur-, Oxaalazijnzuur- En Glutaminezuur-Pyrodruivenzuur-Transaminases in BloedserumRheumatoid Arthritis and Hepatocellular InjuryThe clinical significance of transaminase activities of serumTHE DIAGNOSIS OF ACUTE VIRAL HEPATITIS SIMULATING AN ABDOMINAL EMERGENCY: A CASE REPORT*ELLIS L. ROLETT, M.D., MARVIN H. SLEISENGER, M.D.Liver cell necrosis in chlorpromazine jaundice (allergic cholangiolitis)Zur Kenntnis der Transaminasen im Serum von Pferd, Rind und Schwein*Zur Frage der Serumenzymaktivit�ts�nderungen bei vegetativer GesamtumschaltungSerum Glutamic Oxalacetic Transaminase and Iron in the Differential Diagnosis of JaundiceSerum Enzymes in Hepatic Disease�ber die Bedeutung der Milchs�uredehydrogenase-und Transaminasenbestimmung im KindesalterEvaluation of the transaminase testClinical Significance of Serum-transaminase LevelsParenchymatous Liver Disease (1956-1957)Serum Transaminase and Serum Iron in Liver DiseaseThe Differential Diagnosis of Hepatitis, Cirrhosis and Surgical JaundiceDIAGNOSTIC VALUE OF SERUM-TRANSAMINASE ACTIVITY IN HEPATIC AND GASTROINTESTINAL DISEASESSERUM TRANSAMINASE: THE DIAGNOSTIC VALUE OF THE ESTIMATION IN CARDIAC INFARCTION AND LIVER DAMAGESerum transaminase and other enzymes in acute myocardial infarctionDie Glutamins�ure-Brenztraubens�ure-Transaminase bei LeberkrankheitenSerum Iron and Transaminase in the Differential Diagnosis of JaundiceEvaluation of hepatic dysfunctionEinige Grundprobleme der Störung der Leberfunktion bei der Hepatitis und ihren Folgezuständen 1 November 1956Volume 45, Issue 5Page: 782-800KeywordsAminotransferasesEpidemiologyHepatitisHepatitis AHepatitis EInfectious hepatitisSerum glutamic oxaloacetic transaminaseSkeletal musclesToxic agentsWalking ePublished: 1 December 2008 Issue Published: 1 November 1956 PDF downloadLoading ...