THE PROHYPERTENSIVE AND ANTIHYPERTENSIVE ACTIONS OF THE KIDNEY
Authors: E BRAUN-MENEDEZ
Journal: Annals of Internal Medicine (1958)

Article1 October 1958THE PROHYPERTENSIVE AND ANTIHYPERTENSIVE ACTIONS OF THE KIDNEYE. BRAUN-MENÉDEZ, M.D., F.A.C.P. (Hon.)E. BRAUN-MENÉDEZ, M.D., F.A.C.P. (Hon.)Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-49-4-717 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe role of the kidney in experimental renal hypertension—and probably also in human renal hypertension—is twofold. On the one hand, it has a prohypertensive action mediated by the release into the blood of a pressor substance, renin, which, by acting on a serum α-globulin, produces "angiotensin," an octapeptide with potent vasoconstrictor and pressor actions.On the other hand, the normal kidney tissue exerts some kind of antihypertensive action the exact nature of which is still unknown.This dual and contrariwise role is not unique in the organism. 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Author, Article, and Disclosure InformationAffiliations: Buenos Aires,*Presented as the Lilly Lecture at the Thirty-ninth Annual Session of The American College of Physicians, Atlantic City, New Jersey, April 29, 1958.From the Institute of Physiology, Faculty of Medical Sciences, University of Buenos Aires.Requests for reprints should be addressed to E. Braun-Menéndez, M.D., Institute of Physiology, Faculty of Medical Sciences, University of Buenos Aires, Buenos Aires,Argentina. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byRenal Medullary Blood Flow and Renal Medullary Antihypertensive MechanismsAssessment of the Kidney in Relation to Blood Pressure RegulationAntihypertensive functions of the kidney: Arthur C. 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CLOUGH, M.D. 1 October 1958Volume 49, Issue 4Page: 717-731KeywordsAdrenal cortexBloodHormonesHypertensionKidneys Issue Published: 1 October 1958 Copyright & PermissionsCopyright ©, 1958, by The American College of PhysiciansPDF downloadLoading ...