tbuckley/cabot-search huggingface dataset:
Essentials of Gynecologic and Obstetric Endocrinology.
Authors: Habeeb Bacchus
Journal: Annals of Internal Medicine (1976)

1. Mechanisms of Hormone Actions.- Hormonal Actions Propagated by Release of Membrane Adenyl Cyclase.- Hormonal Actions Propagated by Participation of Cytosol and Nuclear Receptors.- 2. Hypothalamic-Pituitary-Ovarian Axis.- Maturation of Pituitary Gonadotropin Function in Females.- Ovarian Response to Gonadotropins.- Factors Affecting Ambient Levels of Gonadal Hormones.- Hypothalamic-Pituitary Control of Other Endocrine Functions.- 3. The Anterior Pituitary Gland.- Control of the Anterior Pituitary Gland.- Hormones Produced by the Anterior Pituitary Gland.- Assessment of Functions of the Anterior Pituitary Gland.- 4. Gonadal Development.- Ovary from Birth to Puberty.- Disorders of Sexual Development.- The Menstrual Cycle.- Corpus Luteum of Pregnancy.- Steroidogenesis in the Fetoplacental Unit.- Control of Steroidogenesis in Fetal Life.- Other Endocrine Changes in Pregnancy.- Endocrine Changes in the Maternal System in Pregnancy.- Endocrine Changes in Parturition.- Gestational Trophoblastic Neoplastic Syndromes.- 5. Pubertal Development and Disturbances of Menarche.- Changes in the Hypothalamic-Pituitary-Ovarian-Endometrium Axis at the Time of Puberty.- Disorders of Menarche.- 6. Amenorrhea.- Primary Amenorrhea.- Secondary Amenorrhea.- Procedures in Diagnosis of Amenorrhea.- Management of Amenorrhea.- Management of Hirsutism.- 7. Infertility.- Male Infertility.- Female Infertility.- Hormonal Methods of Contraception.- 8. The Breasts.- Maturation of Ductal and Lobule-Alveolar System.- Cyclic Changes in the Breast.- Breast Changes during Pregnancy.- Syndromes of Inappropriate Lactation (Galactorrhea).- Hormonal Effects on Breast Cancer.- 9. The Thyroid Gland.- Biosynthesis of Thyroid Hormones.- Transport of Thyroid Hormones.- Metabolism of Thyroid Hormones.- Regulation of Thyroid Activity.- Metabolic Effects of Thyroid Hormones.- Assessment of Thyroid Function.- Long-Acting Thyroid Stimulator.- Hyperthyroidism.- Hypothyroidism.- Thyroid Cancer.- 10. The Adrenal Cortex.- Adrenocortical Secretion.- Biosynthesis of Adrenocortical Hormones.- Transport of Adrenocortical Hormones.- Further Considerations of Synthesis of Androgens by the Adrenal Cortex.- Steroid Hormone Production in Fetal Adrenals.- Biologic Actions of Adrenocortical Hormones.- Catabolism of Adrenocortical Secretions.- Clinical Disorders of Adrenocortical Function.- Idiopathic Cyclic Edema.- Clinical Syndromes Due to Biosynthetic Defects in the Adrenal Cortex.- Idiopathic Hirsutism.- Feminizing Adrenocortical Tumors.- Laboratory Diagnosis of Adrenocortical Hyperplasia with Biosynthetic Defects.- Summary of Diagnostic Procedures.- 11. Special Topics.- Disorders of Carbohydrate Metabolism.- Clinical Application of Measurements of Hormones and Their Derivatives.
Cancer Drug in Nasal Drops
Authors: Rebecca Voelker
Journal: JAMA (1999)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
DNA‐Binding Small Molecules as Inhibitors of Transcription Factors
Authors: Chung‐Hang Leung, Daniel Shiu‐Hin Chan, Victor Pui‐Yan Ma, Dik‐Lung Ma
Journal: Medicinal Research Reviews (2012)

Abstract Accumulating evidence implicating the role of aberrant transcription factor signaling in the pathogenesis of various human diseases such as cancer and inflammation has stimulated the development of small molecule ligands capable of targeting transcription factor activity and modulating gene expression. The use of DNA ‐binding small molecules to selectively inhibit transcription factor– DNA interactions represents one possible approach toward this goal. In this review, we summarize the development of DNA ‐binding small molecule inhibitors of transcription factors from 2004 to 2011, and their binding mode and therapeutic potential will be discussed.
Predicting Late Myocardial Recovery and Outcomes in the Early Hours of ST-Segment Elevation Myocardial Infarction
Authors: Eric Larose, Josep Rodés-Cabau, Philippe Pibarot, Stéphane Rinfret, Guy Proulx, Can M. Nguyen, Jean-Pierre Déry, Onil Gleeton, Louis Roy, Bernard Noël, Gérald Barbeau, Jacques Rouleau, Jean-Rock Boudreault, Marc Amyot, Robert De Larochellière, Olivier F. Bertrand
Journal: Journal of the American College of Cardiology (2010)
Abstract 3963: MYCN-dependent expression of sulfatase2 regulates neuroblastoma cell survival
Authors: Valeria Solari, Lucia Borriello, G. Esteban Fernandez, Hiroyuki Shimada, Richard Sposto, Shahab Asgharzadeh, Edwin A. Yates, Jeremy E. Turnbull, Yves A. Declerck
Journal: Cancer Research (2014)

Abstract Despite the well-demonstrated role of MYCN in the pathogenesis of neuroblastoma, the mechanisms underlying its oncogenic function are not entirely understood and there is evidence that its function is in part dependent on the tumor microenvironment (TME). Heparan sulfate proteoglycans (HSPG) play a critical role in the interaction between tumor cells and the TME in great part because of their ability to retain cytokines, chemokines and growth factors and to control their bioavailability. This function of HSPG is dependent on the sulfation pattern that itself is controlled by sulfotransferases that add sulfate groups to the repeating disaccharide units and sulfatases (SULF) that selectively remove 6-O-sulfates. An unbiased analysis of the expression of 12 of these enzymes by RT-PCR in 8 human neuroblastoma cell lines revealed higher levels of expression of SULF2 in cell lines with amplification of the MYCN oncogene (MYCN-A), an observation that was confirmed at the protein level by Western blot analysis. We then demonstrated that the knock down (KD) of SULF2 in MYCN-A cells by siRNA resulted in a significant decrease in cell viability caused by a decrease in cell cycle entry and in apoptosis as documented by increase in caspase 3/7 activity, PARP cleavage and annexin-V expression. Evidence was provided that SULF2 is a downstream target of MYCN by demonstrating that overexpression of MYCN in CHLA-255 neuroblastoma cells increased SULF2 expression whereas downregulation of MYCN expression in SHEP-21N cells was followed by a downregulation of SULF2. Underlying the importance of SULF2 in neuroblastoma cell survival independently of MYCN, we demonstrated that overexpression of SULF2 in MYCN-NA cells increased cell viability without increasing MYCN expression. Finally, an analysis of SULF2 protein expression in 65 primary human neuroblastoma tumors indicated a statistically significant higher level of expression in MYCN-A tumors along with an almost complete absence of expression in MYCN-non amplified (NA) tumors, whether they were of favorable or unfavorable histology. The data thus identify SULF2 as a new downstream target of MYCN and a key contributor to its oncogenic function in human neuroblastoma. Citation Format: Valeria Solari, Lucia Borriello, G. Esteban Fernandez, Hiroyuki Shimada, Richard Sposto, Shahab Asgharzadeh, Edwin A. Yates, Jeremy E. Turnbull, Yves A. Declerck. MYCN-dependent expression of sulfatase2 regulates neuroblastoma cell survival. [abstract]. In: Proceedings of the 105th Annual Meeting of the American Association for Cancer Research; 2014 Apr 5-9; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2014;74(19 Suppl):Abstract nr 3963. doi:10.1158/1538-7445.AM2014-3963
Limited application period for dithranol in psoriasis
Authors: HANS SCHAEFER, E. M. FARBER, LEONARD GOLDBERG, W. SCHALLA
Journal: British Journal of Dermatology (1980)

SUMMARY This preliminary study suggests that a 1 h application of dithranol may be effective in the treatment of psoriasis. It is conceivable that short application periods for other topically applied agents, e. g. corticosteroids, may reduce the side-effects in non-affected skin, while maintaining the therapeutic benefit in diseased areas.
Abstract MP06: Sport Club Participation During Adolescence and Sports-Related Physical Activity During Adulthood in Relation to Mortality From Cardiovascular Disease: The JACC Study
Authors: Krisztina Gero, Hiroyasu Iso, Akihiko Kitamura, Kazumasa Yamagishi, Hiroshi Yatsuya, Akiko Tamakoshi
Journal: Circulation (2015)

Background and Purpose:  Taking part in cultural or sport club activities during Junior and Senior high school years is an integral part of Japanese culture. This study examines potential effects of sport club participation during Junior and Senior High School and sports-related physical activity during adulthood on mortality from cardiovascular disease (CVD).   Methods:  Between 1988 and 1990, as part of the Japan Collaborative Cohort (JACC) Study, 29 526 men and 41 044 women aged 40 to 79 years with no history of coronary heart disease (CHD), cerebrovascular disease, or cancer responded to a questionnaire, which included questions regarding the frequency of sports participation at baseline and sport club participation during Junior and Senior high school. A follow-up study was conducted until the end of 2009, and 4230 cardiovascular deaths (870 CHD and 1859 stroke) were identified. Cox proportional-hazard regression model was used to estimate hazard ratios first separately, and then combined for sports participation during Junior and Senior high school, and sports participation during adulthood at baseline. The multivariate model was adjusted for age, sex, BMI, history of hypertension, history of diabetes, smoking status, alcohol intake, hours of sleep, age of completed education, job style, stress, fish intake, and walking time.   Results:  Men and women participating in sports activities at baseline for 5 hours or more per week had a 19% lower risk of CVD mortality compared to the reference category of 1 to 2 hours of sports-related physical activity per week. When examined separately, participation in sport clubs during Junior or Senior high school years was not associated with mortality from CVD. The multivariate-adjusted hazard ratios (95% confidence interval) for CHD and CVD were 0.79 (0.58-1.08) and 0.81 (0.71-0.94), respectively, for sports participation at baseline (≥5h/week versus 1-2h/week); and 0.97 (0.83-1.13) and 0.99 (0.93-1.06), respectively, for sport club participation during Junior or Senior high school years (participants versus non participants). When combined, compared to men and women who did sports for less than 5h/week at baseline and did not participate in sport clubs in Junior or Senior high school, the multivariate-adjusted hazard ratio of CHD for those who did sports for ≥5 h/week and participated in sport clubs was 0.70 (0.46-1.07), and for those who did sports for ≥5h/week but did not participate in sport clubs was 0.90 (0.63-1.27). The corresponding multivariate-adjusted hazard ratios for total CVD were 0.79 (0.66-0.95) and 0.80 (0.68-0.94), respectively.   Conclusion:  Participating in sports activities during adolescence might have an additional risk-reducing effect for CHD mortality among those who participate in sports activities during adulthood.
The Power of Hope
Authors: James C. Harris, Catherine D. DeAngelis
Journal: JAMA (2008)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Abstract 15201: Association Between Diabetic Peripheral Neuropathy and Atrial Fibrillation - A Community Based Case Control Study
Authors: Mohammed N Nazmul, Rowlens M Melduni, Stephen S Cha, Bernard J Gersh, Hon-Chi Lee
Journal: Circulation (2013)

Background: Diabetes Mellitus (DM) as a risk factor of atrial fibrillation (AF) has remained controversial. Emerging evidence indicates that endothelial and vascular dysfunction is associated with AF complications. Since there is a close but complex interaction between nerves and blood vessels, we hypothesized that in patients with Type 2 DM, the presence of peripheral neuropathy (PN) is associated with an increased risk in AF development. Methods: Using electronic medical records of the Mayo Clinic AF Database and the Rochester Epidemiology Project, we identified 780 cases of newly diagnosed AF patients and 1,032 controls with no history of AF, matched by age and gender on 1:1 or 1:2 basis, between 1980 and 2000. Multivariate logistic regression analysis was carried out to calculate Odds ratios and adjust for potentially confounding variables Result: In retrospective analysis, the prevalence of diabetic neuropathy was significantly higher in case compared to control (9.0% vs. 5.0%, p =.002), odds ratio 1...
Ocular Ultrasound in Alagille Syndrome
Authors: Ken K. Nischal, Melanie Hingorani, Christopher R. Bentley, Anthony J. Vivian, Alan C. Bird, Alistair J. Baker, Alex P. Mowat, Georgina Mieli-Vergani, Wagih A. Aclimandos
Journal: Ophthalmology (1997)
A New β2‐Adrenoceptor Agonist – D2343 – with Long Duration
Authors: C.‐G. Löfdahl, N. Svedmyr
Journal: Allergy (1984)

A new β 2 ‐adrenoceptor agonist D2343 has been shown in a human i.v. study to be less potent than terbutaline. Animal experiments showed an increased affinity to lung tissue and a longer bronchodilating effect than terbutaline when inhaled. In a randomized single‐blind, crossover comparison, 2.5 and 5 mg D2343 and 5 mg terbutaline were inhaled by eight asthma patients. We found that 5 mg of D2343 was equipotent to 5 mg terbutaline in bronchodilatory effect measured with FEV 1 . The duration was longer with an increased bronchodilation ( P &lt; 0.01) 6 h after D2343 inhalation compared with terbutaline. The mean fall in FEV 1 3–6 h after inhalation was significantly greater with terbutaline than with D2343 ( P &lt; 0.05). Thus, this study shows that inhaled D2343 has a longer bronchodilating effect than terbutaline.
Abstract 11293: Increased Circulating Asymmetric Dimethylarginine in Chronic Kidney Disease Mice Induces Endothelial Dysfunction by Inhibiting Ca/Calmodulin-Dependent Protein Kinase II-eNOS Signaling
Authors: Hidemi Kajimoto, Hisashi Kai, Hiroki Aoki, Suguru Yasuoka, Takahiro Anegawa, Tsutomu Imaizumi
Journal: Circulation (2010)

Background — Patients with chronic kidney disease (CKD) have impaired endothelial function. The serum asymmetric dimethylarginine (ADMA) level is elevated in CKD. ADMA is known to be an endogenous ...
The European Leisure Time Directive
Authors: James Owen Drife
Journal: BMJ (2001)

The European Working Time Directive, currently causing chaos in the NHS, puts a 48 hour limit on the working week. This is difficult for doctors as most of us warm up only after 48 hours. Indeed, we are starting to panic about how to fill the other 120. Fortunately, help is at hand in the form of the European Leisure Time Directive.

Research has shown that leisure is beneficial to health and therefore, like …
Abstract 15989: Intracoronary Infusion of Multicellular Cardiospheres Can Be Safely Used to Prevent Adverse Remodeling in a Pig Model of Myocardial Infarction
Authors: Romain Gallet, Eleni Tseliou, James Dawkins, Ryan Middleton, Jackelyn Valle, Michelle Kreke, Rachel Smith, Linda Marbán, Eduardo Marbán
Journal: Circulation (2014)

Background: Pre-clinical studies in rodents and pigs indicate that the self-assembling microtissues known as cardiospheres (CSp), when administered intramyocardially, may be more effective than dispersed CSp-derived cells (CDCs). However, the more desirable intracoronary (IC) route has been assumed to be unsafe for CSp delivery: CSp are large (&gt;35 μm), raising concerns about likely microembolization. Objective: We sought to evaluate the safety and efficacy of IC delivery of allogeneic CSp in a porcine model of convalescent MI. Methods: Dosage was optimized by infusing CSp (3.25x10 5 particles [n=2], 6.5 x10 5 [n=3] and 1.3x10 6 [n=2], size=44±23, 29%&gt;50μm) in the LAD of naïve pigs, looking for acute adverse effects (troponin I [TnI] leak, low TIMI flow, stunning). We next tested the efficacy of IC allogeneic Csp (1.3x10 6 ; n=7) or vehicle (n=8) in a minipig model of chronic MI. Animals underwent MRI before infusion and 1 month later. Left ventricular (LV) ejection fraction (EF), scar mass and viable mass were evaluated at both time points. Results: In the dosing study, we observed no impairment of TIMI flow or LVEF after CSp infusion. TnI at 24 hours was 0.7±0.5ng/mL and did not differ among groups (P=0.11). In the post-MI study, EF was identical in the two groups at baseline. One month post-infusion, LV function was preserved in the CSp group but not in controls (ΔEF=+0.5±1.6% vs. -4.5±1.8%, p&lt;0.001). CSp reduced scar mass (P&lt;0.001) and increased viable mass (+17±8% vs. +6±6% from baseline, P=0.04) compared to controls. IC CSp also decreased LV end diastolic pressure (-7±4mmHg vs. -1±4 mmHg in control, P&lt;0.01)) and increased cardiac output (+0.5±0.4 mL/min vs. -0.1±0.3mL/min, P&lt;0.01. Conclusions: IC delivery of allogeneic CSp is safe and preserves LV function after MI. In addition, global hemodynamic improvement is observed, which may have significant clinical implications. The decision to use CDCs or CSp is not forced, therefore, by an inability to infuse CSp safely via the IC route.
Abstract 1938: The Risk of Carotid Endarterectomy Preceding Coronary Artery Bypass Grafting in Patients with Concomitant Significant Coronary Artery Disease and Critical Carotid Stenosis
Authors: Zeshan Rana, Divya Tiwari, Paul Kolm, Nowwar Mustafa, Vinay Hosmane, Michael Metzger, Donna Mahoney, Angela Disabatino, Maria Albert, William Weintraub, Ehsanur Rahman
Journal: Circulation (2007)
Lesson of the Week: Potentially lethal bacterial infection associated with varicella zoster virus
Authors: A. J Pollard, A. Isaacs, E G H. Lyall, N. Curtis, K. Lee, S. Walters, M. Levin
Journal: BMJ (1996)

Chickenpox is generally considered to be a benign self limiting illness in children. Indeed, mild secondary bacterial infection of the skin, of little clinical importance, is the most common complication of varicella virus infection.1 2 There has been a recent increase in reports of serious bacterial infections, however, both during or after chickenpox.

We reviewed the case notes of 13 children (mean age 30 months; seven boys, six girls) who presented to our unit over 12 months (1994-5) with bacterial sepsis associated with chickenpox. We also included one case (case 1) who died of group A streptococcal septicaemia at another hospital.

Occult bacterial infection with group A streptococcus or Staphylococcus aureus may complicate chickenpox and cause potentially lethal disease

An 11 month old girl was admitted with fever, poor feeding, and diarrhoea on the fourth day after the onset of chickenpox. She had a fever of 40°C and a haemorrhagic pustular rash. There was periorbital oedema and conjunctival injection with oral erythema and a 1 cm diameter black necrotic lesion around a vesicle on the dorsum of her left hand. There was no neurological or cardiovascular compromise at presentation.

Twenty four hours later she became shocked with a capillary refill time of four seconds, peripheral core temperature difference of 8°C, blood pressure of 75/40 mm Hg, and a pulse of 150 beats/min. She developed increasing oedema and required supplementary oxygen. Despite resuscitation with colloid and a course of antibiotics she continued to deteriorate and was intubated and mechanically ventilated. Inotropic support and large volumes of colloid were required to correct the shock.

Initial laboratory investigations indicated a haemoglobin concentration of 103 g/l, a white cell count of 7.2 × 109/l, and a platelet count of 119 x109/l with normal clotting. There was hyponatraemia with a …
Medical Mycology. The Pathogenic Fungi and Pathogenic Actinomycetes.
Authors: John Willard Rippon
Journal: Annals of Internal Medicine (1976)

Medical mycology: the pathogenic fungi and the pathogenic actinomycetes , Medical mycology: the pathogenic fungi and the pathogenic actinomycetes , مرکز فناوری اطلاعات و اطلاع رسانی کشاورزی