tbuckley/cabot-search huggingface dataset:
Abstract 2284: Dissecting signaling networks involved in the tumor-microenvironment crosstalk in chronic lymphocytic leukemia (CLL)
Authors: Nupur Bhattacharya, Maiwen Caudron-Herger, Hauke Busch, Karsten Rippe, Hartmut Doehner, Stephan Stilgenbauer, Daniel Mertens
Journal: Cancer Research (2010)

Abstract Crosstalk between tumor cells and the microenvironment is often a prerequisite for carcinogenesis. CLL, the most common leukemia in the western world, is an excellent model system to investigate this microenvironmental crosstalk. The dependence of the CLL cells for pro-survival support from the microenvironment is apparent from the induction of rapid spontaneous apoptosis in CLL cells in vitro unless they are cultured on feeder cells or treated with microenvironmental cytokines. CLL cells are also capable of inducing other non-malignant microenvironmental cells to form a pro-survival niche. We have used a tripartite strategy to characterize the interaction between CLL cells and their microenvironment. Firstly, we have quantified the interaction of pro-survival ligand-receptor pairs and their dose-response curves in primary CLL cells and non-malignant B cells. Of the ligand-receptor pairs tested, IL4 and CD40L were found to rescue primary CLL cells most effectively from apoptosis. The effector dependence of IL4 and CD40L displayed different saturation curves in CLL versus non-malignant B cells, pointing towards distinct differences in ligand-receptor interactions. Secondly, we have used a systems biology approach to identify central nodes in the survival network induced by the microenvironment. The model is generated from the kinetics of the transcriptome acquired from gene expression profiling CLL cells after microenvironmental stimulation. Via a procedure that involves gene-ranking, significance filtering and kinetic classification, deregulated genes have been identified. Model construction using these genes will yield central nodes which will be functionally validated on a cohort of patients. As a third approach, the pro-survival niche inducing property of CLL cells on other microenvironmental cells is studied by gene expression profiling differentiated monocytes, which arise when monocytes are cocultured with CLL cells (which support CLL survival) versus the differentiated monocytes which arise when cultured with non-malignant B cells. Analysis of the gene expression profiles revealed genes specifically deregulated due to the effect of CLL cells. This study will give us a deep insight into the signaling networks operating between the tumor and its microenvironment. This is certainly important for the identification of drug targets which can abrogate this interaction and thereby reduce the viability of the CLL cells in vivo. Note: This abstract was not presented at the AACR 101st Annual Meeting 2010 because the presenter was unable to attend. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 101st Annual Meeting of the American Association for Cancer Research; 2010 Apr 17-21; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2010;70(8 Suppl):Abstract nr 2284.
White Glossy Paper Injurious to the Eye.
Authors: A. C. Simonton
Journal: JAMA (1897)

San Jose, Cal., April 20, 1897. <h3>To the Editor:</h3> —It is not often that one will complain of receiving something that is too good, but I do wish to thus complain at present. While the matter and make up, generally, of theJournal of the Associationhave improved to a high point of excellence, the paper-maker has been endeavoring not to be left in the rear; and he has brought up the excellence of the paper on which theJournalis printed to a degree of perfection altogether too high to be acceptable to many readers of theJournal. As sanitarians and hygienists we ought to practice what we preach. There is not a medical man who will not say at once, when his attention is called to it, that printed matter intended to be read by human eyes—and it is mostly thus intended— should not be impressed on paper
Prophylactic transfer of BCR-ABL–, PR1-, and WT1-reactive donor T cells after T cell–depleted allogeneic hematopoietic cell transplantation in patients with chronic myeloid leukemia
Authors: Martin Bornhäuser, Christian Thiede, Uwe Platzbecker, Alexander Kiani, Uta Oelschlaegel, Jana Babatz, Doris Lehmann, Kristina Hölig, Jörgen Radke, Sebastian Tuve, Martin Wermke, Rebekka Wehner, Hanka Jähnisch, Michael P. Bachmann, E. Peter Rieber, Johannes Schetelig, Gerhard Ehninger, Marc Schmitz
Journal: Blood (2011)
Points: Training of overseas doctors
Authors: N H Gardezi
Journal: BMJ (1982)

September, p 77) express surprise that deaths due to smothering of a baby by a cat do not occur more often.They do not occur more often because most mothers are well aware of the danger.A cat net is a standard piece of baby equipment which is routinely stretched over the pram when it is left unattended in a garden or anywhere frequented by cats.I am astonished that this simple expedient, dictated by common sense rather than by epidemiology, gets no mention in your "Any Questions."'
Health Risks of Radon and Other Internally Deposited Alpha-Emitters, BEIR
Authors: Victor F. Archer
Journal: JAMA (1988)

Although other alpha emitters are reviewed, the emphasis in this report is on radon and its progeny because radon in homes has been identified with the greatest exposure to radiation in our society and as the second most important cause of lung cancer (after cigarettes). It also deals with the effects of most alpha-emitting elements. The unique dosimetry of alpha particles is discussed in detail. The book is not just a review but uses some new modeling techniques to combine data from different sources, including animal data. This is an important step, which distinguishes this review from similar recent reviews on radon made by the National Council on Radiation Protection and Measurements, the National Institute for Occupational Safety and Health, and the International Commission on Radiological Protection. The section on radon combines data from two Canadian, one Swedish, and one US study of underground miners and uses a new lifetime
Relationship between myocardial metabolites and contractile abnormalities during graded regional ischemia. Phosphorus-31 nuclear magnetic resonance studies of porcine myocardium in vivo.
Authors: S Schaefer, G G Schwartz, J R Gober, A K Wong, S A Camacho, B Massie, M W Weiner
Journal: Journal of Clinical Investigation (1990)

The mechanisms responsible for changes in myocardial contractility during regional ischemia are unknown. Since changes in high-energy phosphates during ischemia are sensitive to reductions in myocardial blood flow, it was hypothesized that myocardial function under steady-state conditions of graded regional ischemia is closely related to changes in myocardial high-energy phosphates. Therefore, phosphorus-31 nuclear magnetic resonance spectroscopy was employed in an in vivo porcine model of graded coronary stenosis. Simultaneous measurements of regional subendocardial blood flow, high-energy phosphates, pH, and myocardial segment shortening were made during various degrees of regional ischemia in which subendocardial blood flow was reduced by 16-94%. During mild reductions in myocardial blood flow (subendocardial blood flow = 83% of nonischemic myocardium), only the ratio of phosphocreatine to inorganic phosphate (PCr/Pi), Pi, and [H+] were significantly changed from control. PCr, ATP, and PCr/ATP were not significantly reduced from control with mild reductions in blood flow. Changes in myocardial segment shortening were most closely associated with changes in PCr/Pi (r = 0.94). Pi and [H+] were negatively correlated with segment shortening (r = -0.64 and -0.58, respectively) and increased over twofold when blood flow was reduced by 62%. Thus, these data demonstrate that PCr/Pi is sensitive to reductions in myocardial blood flow and closely correlates with changes in myocardial function. These data are also consistent with a role for Pi or H+ as inhibitors of myocardial contractility during ischemia.
The 'dry' non-eczematous skin associated with atopic eczema*
Authors: A. Y. FINLAY, S. NICHOLLS, C. S. KING, R. MARKS
Journal: British Journal of Dermatology (1980)

The non-eczematous but 'dry' skin of twelve patients with eczema has been studied and contrasted with skin from similar sites in control subjects of similar age and sex and with patients with autosomal dominant ichthyosis. The areas investigated were examined histologically and by techniques for assessment of the stratum corneum structure and function. The 'dry' skin sites demonstrated increased intracorneal cohesion, increased total epidermal thickness, patchy parakeratosis and in places slight hypergranulosis. It is concluded that the dry skin condition of patients with atopic eczema is not autosomal dominant ichthyosis and is probably eczematous in nature.
TECHNIC OF CHOLECYSTOGASTROSTOMY
Authors: J. Tate Mason
Journal: JAMA (1930)

The method of diverting the contents of the gallbladder into the gastro-intestinal tract described here has been used by us for several years. I feel that it is the simplest procedure possible when the necessity of creating a new passage for bile is evident. It is possible to obtain a certain amount of muscular control between the gallbladder and the stomach by separating the muscles of the stomach with a hemostat. For this reason, as well as on account of the inaccessibility of the duodenum, I have not done a cholecystoduodenostomy for years. It is remarkable what beneficial results are obtained and how long these patients continue relatively well.  OPERATIVE PROCEDURE  A small incision 1 cm. long is made on the anterior surface of the stomach wall near the pyloric end about 2 cm. from the greater curvature (fig. 1). The incision is extended into the cavity of the stomach
Mutagenesis from Meiotic Recombination Is Not a Primary Driver of Sequence Divergence between Saccharomyces Species
Authors: M. A. F. Noor
Journal: Molecular Biology and Evolution (2008)

Local rates of recombination positively correlate with DNA sequence diversity in many species. To test whether this relationship stems from mutagenicity of meiotic recombination, studies often look for a similar association between local rates of recombination and sequence "divergence" between species. Because recombination is mutagenic in yeast, I evaluate this assay by testing whether noncoding DNA sequence divergence between Saccharomyces species is related to measures of meiotic double-strand DNA breaks or crossover rates derived from Saccharomyces cerevisiae. Contrary to expectation, I find that sequence divergence is either uncorrelated or negatively correlated with rates of both double-strand break and crossover. Several caveats are mentioned, but these results suggest that mutagenesis from meiotic recombination is not the primary driver of sequence divergence between Saccharomyces species. This study demonstrates that the association between interspecies nucleotide divergence and local recombination rates is not always a reliable indicator of recombination's mutagenicity.
General practice partnerships: till death us do part?
Authors: N. G. Snowise
Journal: BMJ (1992)

OBJECTIVES--To investigate applications for general practice partnership vacancies by established general practitioner principals, the reasons for changing partnerships, and the disincentives to these moves. DESIGN--Confidential postal questionnaire. SUBJECTS--Applicants to 367 general practices in the United Kingdom advertising for a new full time partner. MAIN OUTCOME MEASURES--The proportion of job applications containing at least one application from established principals, proportion of principals appointed as new partners, incentives and disincentives to changing partnership. RESULTS--Of 325 replies (89% response rate) received, 292 were suitable for further analysis. 210/241 (87%) of all applications contained some applications from at least one established principal. 12% of all applications were made by principals. 41/296 (14%) of the newly appointed partners had previously been an established principal. The main reasons for leaving the previous partnership were a desire to move locality or not getting on with previous partners. The disincentives to changing partnerships were largely financial, including the cost of the move and loss of income. CONCLUSIONS--It is possible for established principals in general practice to overcome the disincentives and to change partnerships. There did not seem to be any overall prejudice against appointing principals, in contrast to previously published views.
Policy Implications of Genetic Information on Regulation under the Clean Air Act: The Case of Particulate Matter and Asthmatics
Authors: C. Bradley Kramer, Alison C. Cullen, Elaine M. Faustman
Journal: Environmental Health Perspectives (2005)

The U.S. Clean Air Act (CAA) explicitly guarantees the protection of sensitive human subpopulations from adverse health effects associated with air pollution exposure. Identified subpopulations, such as asthmatics, may carry multiple genetic susceptibilities to disease onset and progression and thus qualify for special protection under the CAA. Scientific advances accelerated as a result of the ground-breaking Human Genome Project enable the quantification of genetic information that underlies such human variability in susceptibility and the cellular mechanisms of disease. In epidemiology and regulatory toxicology, genetic information can more clearly elucidate human susceptibility essential to risk assessment, such as in support of air quality regulation. In an effort to encourage the incorporation of genomic information in regulation, the U.S. Environmental Protection Agency (EPA) has issued an Interim Policy on Genomics. Additional research strategy and policy documents from the National Academy of Science, the U.S. EPA, and the U.S. Department of Health and Human Services further promote the expansion of asthma genetics research for human health risk assessment. Through a review of these government documents, we find opportunities for the inclusion of genetic information in the regulation of air pollutants. In addition, we identify sources of information in recent scientific research on asthma genetics relevant to regulatory standard setting. We conclude with recommendations on how to integrate these approaches for the improvement of regulatory health science and the prerequisites for inclusion of genetic information in decision making.
Researchers Probe Lupus Causes, Treatments
Authors: Tracy Hampton
Journal: JAMA (2007)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Psychodynamics of Paranoia
Authors: N.N. Chatterji
Journal: Psychotherapy and Psychosomatics (1967)

Research Articles| February 12 2010 Psychodynamics of Paranoia Subject Area: Psychiatry and Psychology N.N. Chatterji N.N. Chatterji Lumbini Park Mental Hospital, Calcutta, India Search for other works by this author on: This Site PubMed Google Scholar Psychother Psychosom (1967) 15 (2-4): 105–113. https://doi.org/10.1159/000285883 Article history Published Online: February 12 2010 Content Tools Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Facebook Twitter LinkedIn Email Tools Icon Tools Get Permissions Cite Icon Cite Search Site Citation N.N. Chatterji; Psychodynamics of Paranoia. Psychother Psychosom 31 December 1967; 15 (2-4): 105–113. https://doi.org/10.1159/000285883 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAll JournalsPsychotherapy and Psychosomatics Search Advanced Search Article PDF first page preview Close Modal This content is only available via PDF. 1967Copyright / Drug Dosage / DisclaimerCopyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher.Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. You do not currently have access to this content.
Sjögren's Syndrome in Scurvy
Authors: James Hood, Charlotte A. Burns, Robert E. Hodges
Journal: New England Journal of Medicine (1970)

Five men were deprived of ascorbic acid until they became scorbutic. During deficiency of ascorbic acid, Sjögren's syndrome became apparent in two subjects. In these two and one other keratoconjunctivitis sicca developed. All five had one or more manifestations of the sicca syndrome, including keratoconjunctivitis sicca, enlargement of the salivary glands, xerostomia, dry skin, excessive hair loss, dental decay and recurrent breakdown of dental restorations. Sjögren's syndrome or component features of the syndrome developed when the men had obvious clinical signs of scurvy. Evidence of deficiency other than of ascorbic acid was absent. During repletion with ascorbic acid, as plasma levels of ascorbic acid rose and the size of the body pool of the vitamin increased, the signs of scurvy and of Sjögren's syndrome disappeared. An association between scurvy and Sjögren's syndrome therefore seems apparent.
Perinatal HIV-1 Transmission
Authors: Laurent Mandelbrot, Jérôme Le Chenadec, Alain Berrebi, André Bongain, Jean-Louis Bénifla, Jean-François Delfraissy, Stéphane Blanche, Marie-Jeanne Mayaux, None for the French Perinatal Cohort
Journal: JAMA (1998)

It is unclear whether elective cesarean delivery may have a protective effect against the transmission of human immunodeficiency virus 1 (HIV-1).To investigate whether mode of delivery has an impact on perinatal HIV-1 transmission in the presence of zidovudine prophylaxis.A prospective cohort study.The 85 perinatal centers in the French Perinatal Cohort, from 1985 to 1996.A total of 2834 singleton children born to mothers with HIV-1 infection.Human immunodeficiency virus 1 infection of the infant.No zidovudine was used in 1917 pregnancies and zidovudine prophylaxis was used in 902 pregnancies. Cesarean deliveries were performed in 10.9% on an emergent basis and in 8.3% electively, prior to labor or membrane rupture. In 1917 mothers who did not receive zidovudine, of 1877 with information on mode of delivery, 17.2% transmitted HIV-1 to their child. Risk factors statistically significantly associated with transmission were maternal p24 antigenemia, cervicovaginal infections during pregnancy, amniotic fluid color, and rupture of membranes 4 hours or more before delivery. Mode of delivery was not related to transmission. In 902 mothers receiving zidovudine, transmission was 6.4% in 872 with information on mode of delivery, and elective cesarean delivery (n = 133) was associated with a lower transmission rate than emergent cesarean or vaginal delivery (0.8%, 11.4%, and 6.6%, respectively; P=.002). In a multivariate analysis of all mother-child pairs, including obstetrical risk factors, maternal p24 antigenemia, and zidovudine prophylaxis, interaction between mode of delivery and zidovudine prophylaxis was significant (P=.007). In the multivariate analysis of pregnancies with zidovudine prophylaxis, factors related to transmission rate were maternal p24 antigenemia, amniotic fluid color, and mode of delivery. Adjusted odds ratios (95% confidence intervals) were 1.6 (0.7-3.6) for emergent cesarean delivery and 0.2 (0.0-0.9) for elective cesarean delivery (P = .04) in comparison with vaginal delivery.We observed an interaction between zidovudine prophylaxis and elective cesarean delivery in decreasing transmission of HIV-1 from mother to child. This observation may have clinical implications for prevention.
Non-steroidal anti-inflammatory drugs (NSAIDs) associate with zwitterionic phospholipids: Insight into the mechanism and reversal of NSAID-induced gastrointestinal injury
Authors: Lenard M. Lichtenberger, Zu-Mo Wang, Jimmy J. Romero, Carlos Ulloa, Joseph C. Perez, Marie-Noëlle Giraud, José C. Barreto
Journal: Nature Medicine (1995)
RELATIVE RENAL FUNCTION ESTIMATION FROM EARLY AND DELAY Tc-99m MDP SCINTIGRAPHY: A PROSPECTIVE STUDY
Authors: M Tulchinsky, F Vieras, N Balasubramanian, D M Achong, J J Smith
Journal: Clinical Nuclear Medicine (1989)

Tulchinsky, M; Vieras, F; Balasubramanian, N; Achong, D M; Smith, J J Author Information
Suppression by bone marrow but not by blood T lymphocytes of autologous and allogeneic granulocytic stem cells in a case of lymphoproliferative T‐cell syndrome
Authors: Christine Marinof, Serge Clément
Journal: American Journal of Hematology (1989)

Abstract The bone marrow T lymphocytes of a patient suffering from a lymphoproliferative T‐cell syndrome suppressed the in vitro growth of autologous and allogeneic CFU‐GM. The patient's blood T lymphocytes had no suppressor effect on these same stem cells.
Follow-up of Cases of Opiate Addiction from the Time of Notification to the Home Office
Authors: P. A. L. Chapple, D. E. Somekh, M. E. Taylor
Journal: BMJ (1972)

Follow-up of 108 opiate addicts for a period of six to seven years showed that 35 were still being prescribed opiates, 25 were off drugs, 19 were dead, and for 29 it was not certain whether they were on or off drugs. Most patients who came off drugs did so in the first two years after notification to the Home Office. Clearly treatment is more likely to be successful if given early in the life history of the addict, when it is appropriate to give treatment based on withdrawal of drugs rather than substitution.