tbuckley/cabot-search huggingface dataset:
Abstract 850: Hepatitis B virus genotype, mutations, human leukocyte antigen polymorphisms and their interactions in hepatocellular carcinoma: a multi-centre case-control study
Authors: Juan Wen, Ci Song, Deke Jiang, Tianbo Jin, Xiangjun Zhai, Jianfeng Xu, Hongbing Shen, Zhibin Hu
Journal: Cancer Research (2015)

Abstract Objective:Hepatocellular carcinoma (HCC) is the second leading cause of cancer-related deaths worldwide. Our aim was to evaluate the effects of the hepatitis B virus (HBV) genotype, mutations, HLA single nucleotide polymorphisms (SNPs) and their interactions on HCC risk. Methods: A multi-centre case-control study of 1,507 HBV-related HCC cases and 1,560 HBV persistent carriers as controls was performed. HBV genotype, mutations and genome-wide association studies (GWAS)-identified HLA-DQ/DR SNPs (rs9272105 and rs9275319) were detected. Results: We found that the frequencies of the HBV genotypes B and BC (coinfection) were varied among the studied areas, but genotype C was consistently more frequent in HBV-related HCC (80.6% among HCC vs. 34.4% among the controls). Moreover, 11 HBV hotspot mutations in the EnhII/BCP/PC region were independently and significantly associated with HCC risk. We also detected significant interactions of HLA-DQ/DR rs9272105 with both the HBV genotype and mutations (P &amp;lt; 0.05 for each), but there were not significant interactions for rs9275319. Through a stepwise regression analysis, the HBV genotype, the 11 mutations, HLA-DQ/DR rs9272105 and rs9275319, and the interaction of the mutation A1752G with rs9272105 were all entered into the prediction model of HCC, and the area under the curve (AUC) for the panel including the HLA-DQ/DR SNPs, HBV genotype and mutations was 0.840 (sensitivity = 81.3%, specificity = 74.8%). Conclusions: The HBV genotype, the mutations and the HLA-DQ/DR SNPs may serve as biomarkers for the surveillance of HBV persistent carriers. Large studies with prospective designs are warranted to further evaluate our results. Note: This abstract was not presented at the meeting. Citation Format: Juan Wen, Ci Song, Deke Jiang, Tianbo Jin, Xiangjun Zhai, Jianfeng Xu, Hongbing Shen, Zhibin Hu. Hepatitis B virus genotype, mutations, human leukocyte antigen polymorphisms and their interactions in hepatocellular carcinoma: a multi-centre case-control study. [abstract]. In: Proceedings of the 106th Annual Meeting of the American Association for Cancer Research; 2015 Apr 18-22; Philadelphia, PA. Philadelphia (PA): AACR; Cancer Res 2015;75(15 Suppl):Abstract nr 850. doi:10.1158/1538-7445.AM2015-850
Nephron-Sparing Surgery and Renal Cell Carcinoma
Authors: Jonathan C. Routh, Bradley C. Leibovich, Horst Zincke, Micheal L. Blute
Journal: JAMA (2004)

not a direct test of Taguchi’s hypothesis, it is consistent with the conclusion that the association between the ESR1 polymorphisms and risk of MI is unlikely to be a spurious result of the associations between ESR1 polymorphisms and tooth loss and between tooth loss and risk of MI. Whether the association between tooth loss and risk of MI is at least partially explained by ESR1 polymorphisms needs further research.
THE EARLY DIAGNOSIS OF FILARIASIS AND CERTAIN SUGGESTIONS RELATIVE TO CAUSE OF SYMPTOMS
Authors: W. E. Leede, Allen I. Josey
Journal: Annals of Internal Medicine (1945)

Article1 November 1945THE EARLY DIAGNOSIS OF FILARIASIS AND CERTAIN SUGGESTIONS RELATIVE TO CAUSE OF SYMPTOMSW. E. LEEDE, ALLEN I. JOSEYW. E. LEEDESearch for more papers by this author, ALLEN I. JOSEYSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-23-5-816 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptFilariasis has long been characterized by the physical findings of elephantiasis, lymphadenitis, marked physical deformity, and by the demonstration of microfilariae on blood smear. These features are indicative of a "late stage" of filariasis. The military necessity for occupation of filarial endemic areas has afforded an opportunity to study the "early stages" of filariasis. The syndrome of early filariasis has been outlined by Wartman and King,1and by various medical officers who have recently returned from the area in which filariasis is endemic. Since September of 1943, we have had an opportunity to study the "early stages" of filariasis. All...Bibliography1. WARTMANKING WBBG: Early filariasis in American soldiers—Special article in Bull. U. S. Army Med. Dept., 1944, lxxvi, 45. Google Scholar2. BYRDST. AMANT EEL: Filariasis among Marines. Tutuila, Preliminary Epidemiological Investigation. (Unpublished.) Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: *Received for publication June 9, 1945.From the Medical Clinic of O'Reilly General Hospital. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byFILARIASIS IN IMMIGRANTS IN WESTERN AUSTRALIA, INCLUDING A CASE OF CHYLURIA RECURRING IN SEVEN PREGNANCIESWurmkrankheitenFilarial funiculitisFilariasis in the Pacific 1 November 1945Volume 23, Issue 5Page: 816-822KeywordsArmed forcesBloodFilariasisHospitals ePublished: 1 December 2008 Issue Published: 1 November 1945 PDF downloadLoading ...
SYNDROME OF RUPTURE OF AORTIC ANEURYSM INTO THE PULMONARY ARTERY; REVIEW OF THE LITERATURE WITH REPORT OF TWO CASES
Authors: Richard E. Nicholson
Journal: Annals of Internal Medicine (1943)

ExcerptThe incidence of rupture of an aortic aneurysm into the pulmonary artery is of rare enough occurrence to warrant publication by most clinicians of their respective cases soon after discovery. Even rarer is the antemortem diagnosis of such a condition, because the diagnostician is either unfamiliar with the syndrome or discards the possibility in favor of a more statistical probability.The terminology "arteriovenous" aneurysm or anastomosis with reference to the great vessels leaving the heart is not preferable. Although it is true that with regard to the circulating blood in a communication between pulmonary artery and aorta there is a...
Counselling
Authors: A. Bagshawe
Journal: BMJ (2003)

Subfertility usually affects a person's capacity to function normally in close personal relationships, socially, and at work. Many couples find that facing the problem of subfertility, and coping with the investigations and treatments can cause anxiety, stress, and depression. Demands and pressures may be placed on subfertile couples by different cultural, religious, and familial attitudes towards parenthood and childlessness. These factors can also affect the way each individual feels about and responds to the problem.
Seduced by Death: Doctors, Patients, and the Dutch Cure, by Herbert Hendin
Authors: T. Sheldon
Journal: BMJ (1997)

Herbert Hendin / W W Norton, $27.50, pp 256 ISBN 0 393 04003 8

“If e'er I sow my wheat wi'out brinin, I'm a Dutchman,” Luke tells Maggie in George Eliot's Mill On The Floss . Today, the Dutch remain fools for doing things differently as far as Professor Herbert Hendin's hatchet job on Dutch euthanasia policy, Seduced by Death , is concerned.

Hendin—professor of psychiatry at New York Medical College and executive director of the American Suicide Foundation, which works to prevent suicide—vilifies a policy that allows a “bright and compassionate people” to wrongly end other people's lives in the name of humanitarian goals. At its worst, the book declines into generalised …
Abstract 1457: IGFBP-4-Mediated Wnt Inhibition is Required for Cardiac Myogenesis
Authors: Weidong Zhu, Ichiro Shiojima, Li Zhi, Hiroyuki Ikeda, Masashi Yoshida, Atsuhiko T Naito, Tohru Minamino, Toshio Nagai, Issei Komuro
Journal: Circulation (2008)

Insulin-like growth factor-binding proteins (IGFBPs) bind to and modulate the actions of insulin-like growth factors (IGFs). Although some of the effects of IGFBPs appear to be independent of IGFs, the precise mechanisms of IGF-independent actions of IGFBPs are largely unknown. In this study we demonstrate that IGFBP-4 is a novel cardiogenic growth factor. IGFBP-4 enhanced cardiomyocyte differentiation of P19CL6 embryonal carcinoma cells and embryonic stem (ES) cells in vitro. Conversely, siRNA-mediated knockdown of IGFBP-4 in P19CL6 cells or ES cells attenuated cardiomyocyte differentiation, and morpholino-mediated knockdown of IGFBP-4 in Xenopus embryos resulted in severe cardiac defects and complete absence of the heart in extreme cases. We also demonstrate that the cardiogenic effect of IGFBP-4 was independent of its IGF-binding activity but was mediated by the inhibitory effect on canonical Wnt signaling. IGFBP-4 physically interacted with a Wnt receptor Frizzled 8 (Frz8) and a Wnt co-receptor low-density lipoprotein receptor-related protein 6 (LRP6), and inhibited the binding of Wnt3A to Frz8 and LRP6. Moreover, the cardiogenic defects induced by IGFBP-4 knockdown both in vitro and in vivo was rescued by simultaneous inhibition of canonical Wnt signaling. Thus, IGFBP-4 is an inhibitor of the canonical Wnt signaling, and Wnt inhibition by IGFBP-4 is required for cardiogenesis. The present study provides a molecular link between IGF signaling and Wnt signaling, and suggests that IGFBP-4 may be a novel therapeutic target for heart diseases.
Abstract 20012: Measuring the Sinuses of Valsalva and Left Ventricular Outflow Tract by Cardiac Computed Tomographic Angiography: Incremental Value for Sizing the Valve for Transcatheter Aortic Valve Replacement?
Authors: Nina Rashedi, Selma Durakovic, Edward Gill, William Shuman, Creighton Don
Journal: Circulation (2014)

Background: Accurate assessment of aortic annulus size (AoA) is critical for insuring successful transcatheter aortic valve replacement (TAVR) as well as to minimize para-valvular regurgitation. However, the AoA is occasionally difficult to assess due to challenges caused by annular calcification, motion artifact and improper CT gating. Proper TAVR valve size and sealing is dependent more than just AoA, but rather multiple other measurements including the left ventricular outflow tract (LVOT) diameters and sinuses of Valsalva. We hypothesized that the measurement of sinuses of Valsalva and LVOT by cardiac computed tomographic angiography (CCTA) imaging are important adjunctive measurements in determining the ideal valve size for TAVR. Methods: Consecutive patients evaluated for TAVR underwent single phase, prospective ECG gated CCTA with contrast to evaluate the aortic valve anatomy. Measurements of annular, coronary height, left ventricular outflow tract diameters and areas were performed. Findings were analyzed using ANOVA and regression models. Results: CCTA was performed on 87 patients being evaluated for TAVR. Increasing body surface area (BSA) is weakly associated with AoA and somewhat correlated with sinotubular junction measurements. Sinuses of Valsalva and LVOT are strongly predictive of AoA and the ideal valve size (r 2 =0.66, r 2 =0.86, respectively). Sinuses of Valsalva and LVOT are helpful predictive adjuncts along with AoA in determining the ideal valve size for TAVR, specifically in those with the smallest and largest annular areas (figure 1). Coronary heights were not associated with AoA or BSA. Conclusion: There is a strong association between the annulus size and sinuses of Valsalva diameter and LVOT measured by CCTA. This finding is particularly useful in determining the appropriate valve size in those borderline cases or when accurate aortic annulus dimensions are difficult to obtain.
Effect of Serum on Spontaneous Neoplastic Transformations &lt;italic&gt;In Vitro&lt;/italic&gt;
Authors: V. J. Evans, W. F. Andresen
Journal: JNCI Journal of the National Cancer Institute (1966)

Effect of Serum on Spontaneous Neoplastic Transformations In Vitro Get access V. J. Evans, V. J. Evans Laboratory of Biology, National Cancer Institute,3Bethesda, Maryland 20014 Search for other works by this author on: Oxford Academic PubMed Google Scholar W. F. Andresen W. F. Andresen Laboratory of Biology, National Cancer Institute,3Bethesda, Maryland 20014 Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 37, Issue 2, August 1966, Pages 247–249, https://doi.org/10.1093/jnci/37.2.247 Published: 01 August 1966 Article history Received: 13 April 1966 Published: 01 August 1966
Effect of Pravastatin on Angiographic Restenosis After Coronary Balloon Angioplasty fn1fn1This study was supported by a grant from Bristol Myers Squibb Laboratories, Paris.
Authors: Michel E. Bertrand, Eugène P. McFadden, Jean-Charles Fruchart, Eric Van Belle, Philippe Commeau, Gilles Grollier, Jean-Pierre Bassand, Jacques Machecourt, Jean Cassagnes, Jean-Marie Mossard, André Vacheron, Alain Castaigne, Nicolas Danchin, Jean-Marc Lablanche
Journal: Journal of the American College of Cardiology (1997)
Echocardiographic hemodynamic and morphometric predictors of survival after two-ventricle repair in infants with critical aortic stenosis11All manuscripts by authors from the University of California San Francisco have been reviewed by a Guest Editor.
Authors: John P Kovalchin, Michael M Brook, Geoffrey L Rosenthal, Kenji Suda, Julien I.E Hoffman, Norman H Silverman
Journal: Journal of the American College of Cardiology (1998)
<i>Mycobacterium avium</i>infection of the skin associated with lichen scrofulosorum: report of three cases
Authors: None Komatsu, None Terunuma, None Tabata, None Tagami
Journal: British Journal of Dermatology (1999)

Journal Article Mycobacterium avium infection of the skin associated with lichen scrofulosorum: report of three cases Get access H. Komatsu, H. Komatsu Department of Dermatology, Tohoku University School of Medicine, 1‐1 Seiryo‐machi, Aoba‐ku, Sendai 980‐8574, Japan Search for other works by this author on: Oxford Academic Google Scholar A. Terunuma, A. Terunuma Department of Dermatology, Tohoku University School of Medicine, 1‐1 Seiryo‐machi, Aoba‐ku, Sendai 980‐8574, Japan Search for other works by this author on: Oxford Academic Google Scholar N. Tabata, N. Tabata Department of Dermatology, Tohoku University School of Medicine, 1‐1 Seiryo‐machi, Aoba‐ku, Sendai 980‐8574, Japan Search for other works by this author on: Oxford Academic Google Scholar H. Tagami H. Tagami Department of Dermatology, Tohoku University School of Medicine, 1‐1 Seiryo‐machi, Aoba‐ku, Sendai 980‐8574, Japan Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 141, Issue 3, 1 September 1999, Pages 554–557, https://doi.org/10.1046/j.1365-2133.1999.03059.x Published: 01 September 1999
Lesson of the Week: Occult intracranial tumours masquerading as early onset anorexia nervosa
Authors: C J DeVile, R Sufraz, B D Lask, R Stanhope
Journal: BMJ (1995)

Childhood onset anorexia nervosa may be difficult to diagnose because of the lack of clear diagnostic criteria for prepubertal children and because of the difficulty of differentiating psychogenic from organic disease.' Psychological disturbance and symptoms of anorexia without neurological manifestation may also be presenting features of an early intracranial lesion, usually affecting the diencephalon-as shown by the following three cases.Case reports CASE 1
485. Marked Transfection Enhancement by the DPL (DNA/Peptide/Liposomes) Trimeric Complex
Authors: Wendy E. Walker, Andy D. Miller
Journal: Molecular Therapy (2004)

Although gene expression and even functional correction have been demonstrated following administration of non-viral gene therapy vectors in several clinical trials, this response is generally transient. In this report, we attempt to characterise the dynamics of expression decline in order to more fully understand the causes behind this transience, and thereby rationally design vectors for extended expression.
New Perspectives on Noise-Induced Hearing Loss.
Authors: Colleen G. Le Prell, Donald Henderson
Journal: Annals of Internal Medicine (1983)

Hearing impairment is the third most prevalent chronic disability in the United States, and hearing loss in the speech frequency region (pure-tone average threshold at 0.5, 1, 2, and 4 kHz ≥ 25 dB) is currently estimated to affect 29 million Americans ages 20–69 years based on 2003–2004 data (16% of population; Agrawal et al. 2008). When the higher frequencies are considered (pure-tone average at 3, 4, and 6 kHz ≥ 25 HL), the number affected doubles (Agrawal et al. 2008). Consistent with this, the National Institutes of Health has estimated that some 15% of Americans between the ages of 20 and 69 have hearing loss at higher test frequencies, suggesting the hearing loss may have been caused by exposure to loud sound (National Institute on Deafness and Other Communication Disorders 2002).
The Open Air Breakfast
Authors: M. Therese Southgate
Journal: JAMA (2001)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Abstract 2364: Chronic Heart Failure Leads to an Expanded Plasma Volume and Pseudoanemia, but Does Not Lead to a Reduction in the Body’s Red Cell Mass
Authors: Christopher Adlbrecht, Spyridoula Kommata, Martin Hülsmann, Thomas Szekeres, Christian Bieglmayer, Guido Strunk, Brigitte Stoiser, Georgios Karanikas, Rudolf Berger, Deddo Mörtl, Kurt Kletter, Gerald Maurer, Irene M Lang, Richard Pacher
Journal: Circulation (2008)

Chronic heart failure (CHF) is frequently associated with a decreased hemoglobin level. Although in some patients renal anemia may develop, the mechanisms underlying the decrease in hemoglobin in isolated CHF remain largely unknown. We explored robust determinants of anemia including red cell mass as well as related markers and the plasma volume in patients with CHF without renal dysfunction based on non-cardiac reasons. One-hundred consecutive CHF patients were enrolled. The total red cell volume (RCV) was determined by a 51Cr assay. Furthermore, serum ferritin, erythropoietin, hepcidin, and renal function parameters were assessed. The influence of each factor on hemoglobin concentrations was determined in a multiple regression model. Mean hemoglobin concentrations were 11.7 ± 0.8mg/dL in anemic CHF patients and 14.4 ± 1.2mg/dL in non-anemic patients (p &lt; 0.001). However, the RCV was not reduced (1659.3 ± 517.6mL versus 1826.4 ± 641.3mL, p = 0.194). There was no severe deficiency of iron or erythropoietin detectable in CHF patients but corrected reticulocytes were lower in anemic patients (35.1 ± 15.7G/L versus 50.3 ± 19.2G/L, p = 0.001). We found that plasma volume levels were significantly higher in anemic CHF patients, suggesting the presence of pseudoanemia (70.0 ± 2.4% versus 65.0 ± 4.0%, p &lt; 0.001). Correspondingly, plasma volume was the best predictor of hemoglobin concentrations in the regression model applied (B = − 0.651, p &lt; 0.001, R 2 = 0.769). Hemodilution appears to be the most potent factor for the development of low hemoglobin levels in patients with a broad spectrum of severity of heart failure. Our data support an additional independent, but minor influence of iron deficiency on lower than normal hemoglobin concentrations in CHF patients. The study results support not administering erythropoiesis stimulating agents to unselected CHF patients with lower than normal hemoglobin levels.
Abstract 17098: Smoking is an Independent Modifiable Risk Factor for Incident Heart Failure in Community-Dwelling Older Adults: Findings from a Prospective Population Study
Authors: Mustafa Ahmed, Ravi V Desai, Jason Guichard, Marjan Mujib, Yan Zhang, Margaret A Feller, Amiya Ahmed, Gregg C Fonarow, Ali Ahmed
Journal: Circulation (2010)

Background:  Although smoking is a well-established risk factors for coronary heart disease, little is known about the association between smoking and incident heart failure (HF). The objective of this study was to determine the effect of smoking on incident HF among community-dwelling adults ≥65 years in the Cardiovascular Health Study (CHS).   Methods:  Of the 5338 CHS participants without prevalent HF, 2780 (52%) had a smoking history and 1483 were either current smokers or had smoked within  15 years ago were classified as non-smokers (AHA Policy Statement: risk after abstinence >15 yrs = never-smoker). A multivariable Cox regression model was used to estimate the associations of quartiles of smoking pack-year (PY) with incident HF (reference, non-smokers) during 12 years of follow-up. The model was adjusted for demographics and other cardiovascular risk factors including intercurrent acute myocardial infarction occurring before incident HF (n=259).   Results:  Participants (n=5338) had a mean (±SD) age of 73 (±6) years, 58% were women, and 15% African American. The unadjusted and multivariable-adjusted associations of smoking PY quartiles with incident HF are displayed in the Table. When smoking PY was used as a continuous variable, every 10 PY increase in smoking was associated with a significant 5% increase in the risk of incident HF.   Conclusions:  In community-dwelling older adults, compared to never smokers and those who quit smoking >15 years ago, current smoking was associated with a significant increased risk of incident HF. The association seemed to be the strongest among those with >40 PY of smoking.