Combination Chemotherapy for Malignant Thymoma
Authors: GEDSKE DAUGAARD
Journal: Annals of Internal Medicine (1983)

Brief Reports1 August 1983Combination Chemotherapy for Malignant ThymomaGEDSKE DAUGAARD, M.D., HEINE H. HANSEN, M.D., MIKAEL RØRTH, M.D.GEDSKE DAUGAARD, M.D.Search for more papers by this author, HEINE H. HANSEN, M.D.Search for more papers by this author, MIKAEL RØRTH, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-99-2-189 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptSurgery and radiotherapy have been considered as the primary therapies for malignant thymoma. Recent information on chemotherapy (1-4) and steroidal therapy (5) indicates that invasive thymomas are sensitive to cytostatic agents. Most of the evidence has been presented only in single case reports; we discuss our experience with nine patients.From 1975 to 1982, nine patients with malignant thymoma (histologically classified as thymoma with invasive features at primary surgery) were treated with the same type of combination chemotherapy at the Department of Chemotherapy, Finsen Institute. Thoracotomy was initially done in six patients, sterniotomy in two, and mediastinoscopy in one patient....References1. EVANSTHOMPSONSIMOSONPHILLIPS WDWM. Combination chemotherapy in invasive thymoma: role of COPP. Cancer. 1980;46:1523-7. CrossrefMedlineGoogle Scholar2. BOSTON B. Chemotherapy of invasive thymoma. Cancer. 1976;38:49-52. CrossrefMedlineGoogle Scholar3. CHAHINIANBHARDWAJMEYERJAFFREYKIRSCHNERHOLLAND ASRIPJ. Treatment of invasive or metastatic thymoma: report of eleven cases. Cancer. 1981;47:1752-61. CrossrefMedlineGoogle Scholar4. TALLEYO'BRYANGUTTERMANBROWNLEEMCCREDIE RRJRK. Clinical evaluation of toxic effects of cis-diamminedi-chloroplatinum (NSC-119875): phase I clinical study. Cancer Chemother Rep. 1973;57:465-71. MedlineGoogle Scholar5. SHELLITOKHANDEKARMCKEEVERVICK JJWN. Invasive thymoma responsive to oral corticosteroids. Cancer Treat Rep. 1978;62:1397-400. MedlineGoogle Scholar6. . WHO Handbook for Reporting Results of Cancer Treatment. Geneva: World Health Organization; 1979. (Publication no. 48). Google Scholar7. BERGHGATZINSKYLARSSONLUNDINRIDELL NPSPB. Tumors of the thymus and thymic region: I. Clinicopathological studies of thymomas. Ann Thorac Surg. 1978;25:91-8. CrossrefMedlineGoogle Scholar8. MARKSWALLACEPETTIT RKH. Radiation therapy control of nine patients with malignant thymomas. Cancer. 1978;41:117-9. CrossrefMedlineGoogle Scholar9. LIDNERBERGERATZINGER HKA. Zur Strahlentherapie der Thymome. Strahlentherapie. 1981;157:487-98. MedlineGoogle Scholar10. HANSENDOMBERNOWSKYHANSENHIRSCH HPMF. Chemotheraphy of advanced small-cell anaplastic carcinoma: superiority of four-drug combination to three-drug combination. Ann Intern Med. 1978;89:177-81. LinkGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Finsen Institute Copenhagen, Denmark PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByThymoma and Thymic CarcinomaThymoma and Thymic CarcinomaUncommon Thoracic TumorsRadiotherapy for Thymic NeoplasmsMultimodality Treatment of Thymic TumorsCurrent chemotherapy options for thymic epithelial neoplasmsTreatment of Thymoma: A Comparative Study Between Thailand and the United States and a Review of the LiteratureTreatment of Invasive Thymoma With Single-Agent IfosfamideNonsurgical management of malignant thymomaThymoma—Prognostic Factors and OutcomeCombination Chemotherapy with a Five-Drug Regimen for Invasive ThymomaThymoma. A retrospective study of 87 casesThe role of chemotherapy in invasive thymoma: a review of the literature and considerations for future clinical trialsChemotherapy and operation for invasive thymomaGlucocorticoid receptors in human malignancies: A reviewChemotherapy for invasive thymoma. A 13-year experiencePost-operative radiotherapy in invasive thymomaSuccessful treatment of metastatic thymic carcinoma with cisplatin, vinblastine, bleomycin, and etoposide chemotherapyMetastasizing thymoma and myasthenia gravis. Favorable response to glucocorticoids after failed chemotherapy and radiation therapyLate Pseudo-Exacerbation of Myasthenia Gravis Due to Ectopic Thymoma Invading Lower Cranial NervesChemotherapy for Invasive ThymomasChemotherapy of invasive thymoma. A retrospective study of 22 casesChemotherapy in thymoma and myasthenia gravisTumors of the thymusTimomas invasivos: presentacion de cinco casos y revision de la literaturaTherapiekonzepteA proposal for treatment of invasive thymomaChemotherapy in invasive thymomas: Five case reportsChemotherapy of malignant thymoma. Case report and review of the literatureRemission of Invasive Thymoma due to Chemotherapy*Primary Malignant Mediastinal TumorsChemotherapy for Malignant Thymoma 1 August 1983Volume 99, Issue 2Page: 189-190KeywordsChemotherapyCombination chemotherapySteroid therapySurgeryThoracotomyThymoma Issue Published: 1 August 1983 PDF DownloadLoading ...