Severe Neutropenia Associated with Ticarcillin Therapy
Authors: DENNIS GASTINEAU
Journal: Annals of Internal Medicine (1981)

Letters and Corrections1 May 1981Severe Neutropenia Associated with Ticarcillin TherapyDENNIS GASTINEAU, M.D., REYNOLD SPECTOR, M.D., DAVID PHILIPS, M.D.DENNIS GASTINEAU, M.D.Search for more papers by this author, REYNOLD SPECTOR, M.D.Search for more papers by this author, DAVID PHILIPS, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-94-5-711_2 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: Ticarcillin, a semisynthetic penicillin with a spectrum of activity similar to that of carbenicillin, has been particularly useful in conjuction with the aminoglycosides in treating bacteremia due to Pseudomonas aeruginosa. Although neutropenia has been reported in association with several penicillins (1), it has not previously been reported with ticarcillin. We report a patient in whom extreme neutropenia associatedwith ticarcillin therapy developed and recurred with reexposure to the drug.A 48-year-old woman was admitted to the University of Iowa Hospital for evaluation of hepatosplenomegaly and angina. Initial laboratory values included normal segmented neutrophil, platelet, and total leukocyte...References1. HOMAYOUNI H, GROSS P, SETIA U, and LYNCH T. Leukopenia due to penicillin and cephalosporin homologues. Arch Intern Med. 1979;139:827-8. CrossrefMedlineGoogle Scholar2. KRAMER M, LEVENTHAL J, HUTCHINSON T, and FEINSTEIN A. An algorithm for the operational assessment of adverse drug reactions I. Background, description, and instructions for use. JAMA. 1979;242:623-32. CrossrefMedlineGoogle Scholar3. VARELA-DURAN J, ROHOLT P, and RATLIFF N. Sea-blue histocyte syndrome. Arch Pathol Lab Med. 1980;104:30-4. MedlineGoogle Scholar4. CHU J, O'CONNOR D, and SCHMIDT R. The mechanism of oxacillin-induced neutropenia. J Pediatr. 1977;90:668-9. Letter. CrossrefMedlineGoogle Scholar5. CARPENTER J. Neutropenia induced by semisynthetic penicillin. South Med J. 1980;73:745-8. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: DENNIS GASTINEAU, M.D.; REYNOLD SPECTOR, M.D.; DAVID PHILIPS, M.D.Affiliations: University of Iowa Hospitals and Clinics Iowa City, IA 52242 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byHigher Risk of Neutropenia Associated With Piperacillin-Tazobactam Compared With Ticarcillin-Clavulanate in ChildrenCarbenicillin, Carindacillin, Carfecillin and TicarcillinTicarcillin–Clavulanic AcidAgranulocytosis Induced by Vancomycin or Ticarcillin/ClavulanateChemical Agents Which Suppress Myelopoiesis: Agranulocytosis and LeukemiaAgranulocytosis associated with semisynthetic penicillins and cephalosporinesPenicillins, cephalosporins and tetracyclines 1 May 1981Volume 94, Issue 5Page: 711-712KeywordsAnginaBacteremiaDrug therapyHepatosplenomegalyNeutropeniaNeutrophilsPenicillinPlateletsPseudomonas aeruginosaResearch laboratories ePublished: 1 December 2008 Issue Published: 1 May 1981 PDF downloadLoading ...