tbuckley/cabot-search huggingface dataset:
Detection of diseased coronary artery by exercise ST-T maps in patients with effort angina pectoris, single-vessel disease, and normal ST-T wave on electrocardiogram at rest.
Authors: I Kubota, K Hanashima, K Ikeda, K Tsuiki, S Yasui
Journal: Circulation (1989)

To examine the clinical significance of ST-T isopotential maps, 87-lead body surface mapping was performed after treadmill exercise in 21 patients with effort angina pectoris, single-vessel disease, and normal ST-T waves on the resting electrocardiogram. Single-vessel disease was found in the left anterior descending artery (LAD) (nine patients), in the right coronary artery (RCA) (seven patients), and in the left circumflex artery (LCx) (five patients). At 40 msec after the J point, the isopotential maps showed the site of the minimum to be in the left anterior chest in all patients. According to the changes in the position of the minimum from the ST segment to the T wave, postexercise maps were classified into four types. Type A maps (n = 8) were characterized by the persistence of the minimum in the left anterior chest until its negativity decreased and until it became less negative than another minimum that subsequently appeared in a different position. Type B maps (n = 6) were characterized by the gradual movement of the minimum toward the lower thoracic surface. Type C maps (n = 5) were characterized by the gradual movement of the minimum to the left upper direction and then to the back. Type D maps (n = 2) did not show any of the characteristics of A, B, or C. All patients with type A, type B, or type C maps had single-vessel disease of LAD, RCA, or LCx, respectively.(ABSTRACT TRUNCATED AT 250 WORDS)
The place of Shepard in the world of perception
Authors: Walter Gerbino
Journal: Behavioral and Brain Sciences (2001)

To balance Kubovy &amp; Epstein, I evaluate the relationship between Shepard and Gestalt theorists along three dimensions. First, both discover internal universals by reducing external support. Second, they share strengths and weaknesses of the minimum principle. Third, although their attitudes toward an evolutionary account of perception is superficially different, they are fundamentally similar with respect to the internalization process. [Kubovy &amp; Epstein; Shepard]
Abstract 39: Mir-21 regulates TGF-β1-induced CAF formation through Smad7
Authors: Jun Mi
Journal: Cancer Research (2012)

Abstract The TGF-β1, one of major cytokines secrected by tumor cells, not only promotes the growth of tumor cells themselves, but also transforms the adjacent stroma cells into cancer-associated fibroblast formation. However, the detail mechanism by which TGF-β1 induces CAF (cancer-associated fibroblast) formation is unveiled. In this study, the primary fibroblast from skin was successfully transformed into CAF in vitro. These TGF-β1-induced CAF cells significantly promoted the tumor growth in the A175 xenografted mice model. Moreover, the TGF-β1 stimulation not only increased the amount of miR-21, but also reduced the protein level of Smad 7 in primary fibroblast. The TGF-β1 accelerated the Drosha-mediated miR-21 maturation and the Smad 7 was identified to be a target of miR-21. Both the overexpression of miR-21 and knocking down of Smad 7 induced the CAF formation, which represented the TGF- β1 triggered phenotype in primary fibroblast. The Smad 7 physically associates with the Smad 2/3 and regulates the activation of Smad 2/3. The activation of Smad signaling globally changed the status of chromatin and triggered the reprogramming process and transformed the primary fibroblast into CAF. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 103rd Annual Meeting of the American Association for Cancer Research; 2012 Mar 31-Apr 4; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2012;72(8 Suppl):Abstract nr 39. doi:1538-7445.AM2012-39
Stereotypical Relationship Patterns and Psychopathology
Authors: M. Cierpka, M. Strack, D. Benninghoven, H. Staats, R. Dahlbender, D. Pokorny, G. Frevert, G. Blaser, H. Kächele, M. Geyer, A. Körner, C. Albani
Journal: Psychotherapy and Psychosomatics (1998)

&lt;b&gt;Background: &lt;/b&gt;We explored the relationship between the consistency of relationship patterns and the severity of psychopathology. &lt;b&gt;Method: &lt;/b&gt;Relationship patterns were assessed by means of Relationship Anecdote Paradigm interviews rated according to the Core Conflictual Relationship Theme (CCRT) method. The repetition of the same type of CCRT components across relationship narratives indicated stereotypical patterns. &lt;b&gt;Results: &lt;/b&gt;Subjects treated in an inpatient setting (n = 25) told narratives with more consistent patterns than subjects in an outpatient setting (n = 32). Relationship episodes of normal adults (n = 23) were more flexible compared with the two clinical groups. Especially repetitions of the wish component were closely associated with the severity of psychopathology assessed by SCL-90R. &lt;b&gt;Conclusions: &lt;/b&gt;The consistency of relationship patterns seems to be connected with the severity of psychopathology.
MORPHINISM IN MEDICAL MEN.Read in the Section on Practice of Medicine, at the Forty-fifth Annual Meeting of the American Medical Association, held at San Francisco. June 5-8. 1894.
Authors: J. B. MATTISON
Journal: JAMA (1894)

It is a fact—striking though sad—that more cases of morphinism are met with among medical men than in all other professions combined. It is too true that a very large proportion of cases in general are found in our own fraternity. In a paper, "Opium Addiction among Medical Men," presented in the<i>Medical Record</i>, eleven years ago—June 9, 1883, reference was made to the dismissal within a week of a half dozen doctors recovered from this disease, and attention called to the surprising frequency with which it occurs in this particular class. Another decade of professional work exclusively given to the betterment of such patients has brought no decrease in this number; indeed the reverse has quite steadily obtained, so that in a paper, "The Ethics of Opium Habitués,"<i>Medical and Surgical Reporter</i>, Sept. 8, 1888, in a résumé of 300 cases, we noted 118 doctors, and of 125 most
Treatment of <i>Mycobacterium avium</i> Complex Bacteremia in AIDS with a Four-Drug Oral Regimen
Authors: Carol A. Kemper, Tze-Chiang Meng, Joseph Nussbaum, Joseph Chiu, David F. Feigal, Angie E. Bartok, John M. Leedom, Jeremiah G. Tilles, Stanley C. Deresinski, J. Allen McCutchan
Journal: Annals of Internal Medicine (1992)

▪ Objective: To determine the quantitative microbiologic response and the clinical response of patients with Mycobacterium avium complex bacteremia and AIDS to an oral antimycobacterial regimen. ▪ Design: A phase II, multicenter clinical trial. ▪ Setting: Four university-affiliated medical centers. ▪ Patients: Forty-one patients with HIV infection who had at least two consecutive blood cultures positive for M. avium complex and who had not received previous antimycobacterial therapy were enrolled in the study. Thirty-one patients were valuable with regard to the efficacy of the oral regimen. ▪ Interventions: Patients received a combination of orally administered rifampin (600 mg), ethambutol (15 mg/kg body weight), clofazimine (100 mg once daily), and ciprofloxacin (750 mg twice daily) for 12 weeks. Parenterally administered amikacin, 7.5 mg/kg daily for 4 weeks after the first 4 weeks of oral therapy, was used at the discretion of the individual investigator. ▪ Measurements: Clinical symptoms, Karnofsky scores, and adverse events were monitored. Colony counts for M. avium complex were determined. ▪ Main Results: The mean logarithmic (log) baseline colony count decreased from 2.1 to 0.7 after 4 weeks of oral therapy (P < 0.001). Suppression of bacteremia was sustained throughout therapy. Thirteen patients (42%) became culture negative during therapy. The mean duration of treatment was 9.7 weeks. Nineteen evaluable patients (61%) completed 12 weeks of therapy. Adverse reactions to one or more agents were common. ▪ Conclusions: A rapid reduction in symptoms and bacteremia can be achieved as early as week 2 of therapy using an oral regimen of rifampin, ethambutol, clofazimine, and ciprofloxacin. Colony counts rose dramaticallyafter therapy was discontinued, suggesting that more prolonged periods of therapy are necessary to eradicate systemic infection.
EXPERIMENTAL OBSERVATIONS ON THE SO-CALLED SENILE CHANGES OF INTRACELLULAR NEUROFIBRILS
Authors: KARL STERN, K. A. C. ELLIOTT
Journal: American Journal of Psychiatry (1949)

Various observations reported in the literature suggest that the so-called Alzheimer changes of the intracellular neurofibrils in senile and presenile conditions are associated with dehydration. In the present experiments rabbits' brains were dehydrated in vivo by intravenous administration of 25% glucose solution. Microscopic examination showed that in some nerve cells, irregularly scattered in the brain, the intracellular argentophile fibres become coarse, and have a tendency to become matted strands. The nucleus remains intact. These changes correspond to the initial stages of Alzheimer's cell change in man as encountered in senile and presenile conditions. These findings are discussed in the light of the literature on this subject. The histological findings in experimental hydration are also reported.
Hospitals and benefactors
Authors: C G D Brook
Journal: BMJ (1994)

EDITOR, - The anguish felt by benefactors when their gift is apparently spurned is understandable, but it would be disastrous if potential benefactors were discouraged by the current furore about funding hospital building in south London.1 Charitable money has become essential to services and research.

People like to see something for their money; thus equipment is easy to fund, especially if it has to do with hearts, children, or cancer. Public collections for the construction of buildings have a long history, as inscriptions on many hospitals testify. …
Recent advances in plant hepatoprotectives: A chemical and biological profile of some important leads
Authors: Arvind S. Negi, J.K. Kumar, Suaib Luqman, Karuna Shanker, M.M. Gupta, S.P.S. Khanuja
Journal: Medicinal Research Reviews (2007)

Abstract Medicinal plants have been traditionally used for treating liver diseases since centuries. Several leads from plant sources have been found as potential hepatoprotective agents with diverse chemical structures. Although, a big list of hepatoprotective phytomolecules was reported in the scientific literature, only a few were potent against various types of liver damages. Of which, silymarin, andrographolide, neoandrographolide, curcumin, picroside, kutkoside, phyllanthin, hypophyllanthin, and glycyrrhizin have largely attracted the scientific community. This review focuses discussion on the chemistry, biological activity, mode of action, toxicity, and future prospects of these leads. © 2007 Wiley Periodicals, Inc. Med Res Rev, 28, No. 5, 746–772, 2008
An electrical impedance technique for assessment of wheals
Authors: M. Nyrén, S. Ollmar, I. Nicander, L. Emtestam
Journal: Allergy (1996)

In previous studies of the electrical impedance of the skin, we introduced a set of physical indices which could be used to distinguish between the cutaneous effects produced by different irritants and allergic contact reactions. In this study, wheals were induced in 10 allergic patients by performing prick tests on the forearm with the relevant allergen and histamine, respectively. Normal skin was used for control. The wheals were evaluated by visual scoring, laser Doppler, and electrical impedance. As expected, there was a close agreement between the visual and laser Doppler readings. Compared to the controls, there were significant changes in the electrical impedance of the wheals, especially in the index related to the phase angle. The changes in the indices were found to follow a particular pattern, which diverged from those obtained in contact skin reactions of both allergic and irritant type. Our results indicate that, by the application of the impedance technique, it will be possible to characterize objectively and quantify the wheal reaction. The results also suggest that cutaneous reactions of completely different causes, such as allergic skin reactions of the late and immediate type, and irritant contact reactions, may be distinguished on the basis of their effects on the electrical impedance of the skin.
Studies on the Renal Humoral Mechanism of Chronic Experimental Hypertension
Authors: ALBERTO C. TAQUINI, PEDRO BLAQUIER, ALBERTO C. TAQUINI
Journal: Circulation (1958)

The renin content of the kidneys from chronic renal hypertensive dogs rises when the kidneys are transplanted to the neck of a normotensive nephrectomized animal. This elevation precedes and accompanies the elevation of the blood pressure of the recipient. This type of experiment does not allow one to draw conclusions concerning the humoral mechanism of chronic renal hypertension.
Surgical Treatment of Mitral Stenosis: A Medical Milestone
Authors: Lawrence H. Cohn, John J. Collins
Journal: New England Journal of Medicine (1973)

Mitral stenosis is not only one of the most distressing forms of cardiac disease, but in its severe forms it resists all treatment by medicine. [Sir Lauder Brunton, 1902.]1 The anniversary of a milestone in the surgical treatment of valvular heart disease is celebrated in 1973. It is the 50th anniversary of the successful clinical operation for acquired mitral-valve disease performed in May, 1923, at the Peter Bent Brigham Hospital by Dr. Elliot Carr Cutler with the medical consultation of his colleague, Dr. Samuel A. Levine.2 Dr. Cutler was associate in surgery at the Peter Bent Brigham Hospital and was . . .
Genetic variability of the 2 adrenergic receptor and asthma exacerbations
Authors: S B Liggett
Journal: Thorax (2006)

Predictive value of genetic tests for asthma exacerbations

The treatment of asthma remains a formidable task for clinicians, despite the development of new treatment options such as long acting β agonists, potent inhaled corticosteroids, and leukotriene receptor antagonists. The complexities in treatment arise not only from temporal changes in the clinical status of patients (such as viral infections and allergy exposures), but also from the well recognised variability between individuals in the response to treatment. This variability is found with the most widely used treatment for asthma—the β agonists—which act to dilate constricted airways by binding to the β2 adrenoceptor on airway smooth muscle. It has been suggested that up to 50% of the variability in response to β agonists between individuals has a genetic basis.1 Beta agonists evoke smooth muscle relaxation in airways that have become constricted from virtually any spasmogen, so it is no wonder they have a central role in treating asthma.

However, several aspects of β2 adrenoceptor signalling have been lurking in the shadows for many years. Firstly, in virtually every cell type that has been studied, chronic exposure (∼8 hours or more) to β agonists results in a loss of receptor expression with accompanying desensitisation of the cellular response.2 At the physiological level, desensitisation could be manifested as tachyphylaxis. Clinically, tachyphylaxis to β agonists could lead to a variety of outcomes such as progressive loss of the bronchodilating effect, a loss of the protective effect against bronchoconstriction, and increased exacerbations. It has also been recognised for over 25 years that corticosteroids increase β2 adrenoceptor expression,3 which could mitigate against agonist promoted downregulation.4 The clinical response to corticosteroids in asthma may therefore involve both anti-inflammatory effects which reduce local spasmogens, as well as improvement in β2 adrenoceptor signalling. …
Isolation Practices in Hospitals
Authors: ROBERT A. WEINSTEIN
Journal: Annals of Internal Medicine (1987)

Letters and Corrections1 November 1987Isolation Practices in HospitalsROBERT A. WEINSTEIN, M.D., SHERWIN A. KABINS, M.D.ROBERT A. WEINSTEIN, M.D., SHERWIN A. KABINS, M.D.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-107-5-781_2 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: We were encouraged to find that Lynch and colleagues (1) have rethought the role of isolation practices in hospitals, as have others (2). We have long favored using barrier precautions to prevent horizontal transmission from colonized as well as infected patients (3, 4) and have also felt that in selected settings the use of gloves (or no-touch techniques) can remove more onerous barriers (5).We have four notes of caution in addition to those raised by Garner and Hughes (6). First, we have shown contamination of the hands of personnel who have used gloves during care of...References1. LYNCHJACKSONCUMMINGSSAMM PMJW. Rethinking the role of isolation practices in the prevention of nosocomial infections. Ann Intern Med. 1987;107:243-6. LinkGoogle Scholar2. GERBERDING J. Recommended infection-control policies for patients with human immunodeficiency virus infection. N Engl J Med. 1986;315:1562-4. CrossrefMedlineGoogle Scholar3. WEINSTEINNATHANGRUNESFELDERKABINS RCRS. Endemic aminoglycoside resistances in gram-negative bacilli: epidemiology and mechanisms. J Infect Dis. 1980;141:338-45. CrossrefMedlineGoogle Scholar4. WEINSTEINKABINS RS. Strategies for prevention and control of multiple-drug resistant nosocomial infections. Am J Med. 1981;70:449-54. CrossrefMedlineGoogle Scholar5. WEINSTEINBOYERLINN RKE. Isolation guidelines for obstetrical patients and newborns. Am J Obstet Gynecol. 1983;146:353-60. CrossrefMedlineGoogle Scholar6. GARNERHUGHES JJ. Options for isolation precautions. Ann Intern Med. 1987;107:248-50. LinkGoogle Scholar7. OLSONWEINSTEINNATHANCHAMBERLINKABINS BRCWS. Occult aminoglycoside resistance in Pseudomonas aeruginosa: epidemiology and implications for therapy and control. J Infect Dis. 1985;152:769-74. CrossrefMedlineGoogle Scholar8. FLYNNWEINSTEINNATHANGASTONKABINS DRCMS. Patients' endogenous flora as the source of "nosocomial" Enterobacter in cardiac surgery. J Infect Dis. 1987;156:363-8. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Michael Reese Hospital and Medical Center Chicago, IL 60616 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByHandwashing and Glove Use in a Long-Term-Care FacilityGuideline for Isolation Precautions in HospitalsGuideline for Isolation Precautions in HospitalsAdoption of Guidelines for Universal Precautions and Body Substance Isolation in Canadian Acute-Care Hospitals 1 November 1987Volume 107, Issue 5Page: 781-782 Issue Published: 1 November 1987 PDF DownloadLoading ...
Genome-Wide Scan Identifies Novel QTLs for Cholesterol and LDL Levels in F2[Dahl R×S]-Intercross Rats
Authors: Victoria L.M. Herrera, Tamara Didishvili, Lyle V. Lopez, Richard H. Myers, Nelson Ruiz-Opazo
Journal: Circulation Research (2004)

Hypercholesterolemia is a significant risk factor for coronary artery disease development. Genes influencing nonmonogenic hypercholesterolemia susceptibility in humans remain to be identified. Animal models are key investigative systems because major confounding variables such as diet, activity, and genetic background can be controlled. We performed a 121-marker, total genome-analysis of an F2[Dahl RxS]-intercross selected for contrasting parental strain susceptibilities for hyperlipidemia on regular rat diets at 6 months of age. Quantitative traits studied were plasma total cholesterol, triglyceride, HDL, and LDL levels adjusted for obesity. Genome-wide analysis of 200 F2-intercross male rats detects two QTLs with highly significant linkage for total cholesterol (TC) on chromosome (chr) 5-133.3 Mbp (LOD 5.8), and chr5-54.2 Mbp (LOD 4.8), and two QTLs with significant linkage for TC: on chromosome 8, chr8-60.4 Mbp (LOD 3.8), and chromosome 2, chr2-243.5 Mbp (LOD 3.4). A QTL for LDL with significant linkage is detected on chromosome 5, chr5-104 Mbp (LOD 3.7). These QTLs contribute from 7% to 12% of total trait variance, respectively, with Dahl-S allele effects resulting in increased TC and LDL levels consistent with hyperlipidemia susceptibility in the parental Dahl-S rat strain. Predicted QTL-peaks do not coincide with previous genome scans. Human homologues of two TC-QTLs span genes listed in a LocusLink profile for cholesterol. Only suggestive loci were detected for HDL and total triglyceride levels. Altogether, the data demonstrates the contribution of multiple QTLs to hypercholesterolemia making a multipathway pathogenic framework imperative. QTL-peak candidate genes delineated are syntenic between rat and human genomes, increasing clinical relevance and mandating further study.
Splenic-Perisplenic Infected Hematoma Detected on Radiogallium-Radiocolloid Subtraction Study
Authors: MELISSA M. LANTZ, MICHAEL D. BOURQUE, JAMES D. SLAVIN, RICHARD P. SPENCER
Journal: Clinical Nuclear Medicine (1995)

An 18-year-old man had a CT documented splenic hematoma. Chills and abdominal tenderness later developed. CT and ultrasound results were consistent with a splenic hematoma and perisplenic fluid. A Ga-67 citrate/Tc-99m SC subtraction study showed radiogallium excess in the inferior spleen and the perisplenic area. An infected splenic hematoma with an infected perisplenic collection was found and successfully aspirated.
SO-CALLED NEW DISEASES
Authors: B. M. Fried
Journal: JAMA (1935)

To the Editor:—  Besides infantile paralysis and encephalitis spoken of by Hans Zinsser (The Journal, May 11, p. 1700), many other diseases with marked characteristics have emerged within the last century, and even within the last few years. This seems  in view of the fact  it is often stated  physicians of the past possessed a very keen  of observation and their horse sense was by far superior to modern clinical and laboratory methods.  In this connection it is of interest to quote a statement by the French clinician Edouard Rist:  It is strange, writes Rist (La tuberculose, Paris, Librairie Arman Colin, 1927), that certain affections, the symptoms and course of which appear to us sufficiently characteristic as to be distinguished by simple clinical observation without the assistance of special technical methods, failed to be identified by our predecessors for many centuries. Measles and scarlet fever, for