STUDIES ON THE EFFECT OF MASSIVE QUANTITIES OF SODIUM BICARBONATE ON THE ACID BASE EQUILIBRIUM AND ON RENAL FUNCTION
Authors: JOSEPH B. KIRSNER
Journal: Annals of Internal Medicine (1943)

Case Reports1 January 1943STUDIES ON THE EFFECT OF MASSIVE QUANTITIES OF SODIUM BICARBONATE ON THE ACID BASE EQUILIBRIUM AND ON RENAL FUNCTIONREPORT OF A CASE WITH REMARKABLE TOLERANCE*JOSEPH B. KIRSNER, M.D., Ph.D., WALTER LINCOLN PALMER, M.D., Ph.D., F.A.C.P.JOSEPH B. KIRSNER, M.D., Ph.D.Search for more papers by this author, WALTER LINCOLN PALMER, M.D., Ph.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-18-1-100 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptINTRODUCTIONAlthough considerable emphasis has been placed on the development of alkalosis during the alkali treatment of peptic ulcer, this complication does not occur in most patients so treated. Recent studies1have indicated that therapy may be continued for many years without significant alteration either in the acid base balance or in renal function. Berger,2Jeghers and Lerner,3and others occasionally have observed patients in whom the prolonged use of large quantities of sodium bicarbonate and calcium carbonate caused no apparent untoward effects. This remarkable tolerance to alkalis is particularly well illustrated by the following case in which the ingestion...Bibliography1. KIRSNERPALMER JBWL: Alkalosis complicating the Sippy treatment of peptic ulcer. An analysis of 135 episodes, Arch. Int. Med., 1942, lxix, 789. CrossrefGoogle Scholar2. BERGER EH: Importance of kidney function in alkalosis, Northwest Med., 1937, xxxvi, 125. Google Scholar3. JEGHERSLERNER HHH: The syndrome of alkalosis complicating the treatment of peptic ulcer: Report of cases with a review of the pathogenesis, clinical aspects, and treatment, New England Jr. Med., 1936, ccxiv, 1236. CrossrefGoogle Scholar4. PETERSVAN SLYKE JPDD: Quantitative clinical chemistry, Vol. 2, Methods, 1931, Williams and Wilkins, Baltimore, pp. 835, 283, 796, 367. Google Scholar5. VAN SLYKE DD: Observations on the course of different types of Bright's disease and resultant changes in renal anatomy, Medicine, 1930, ix, 257. CrossrefGoogle Scholar6. STADIEROSS WCEC: Micro method for determination of base in blood and serum and other biological materials, Jr. Biol. Chem., 1925, xlv, 735. CrossrefGoogle Scholar7. PALMERVAN SLYKE WWDD: Studies of acidosis. IX. Relationship between alkali retention and alkali reserve in normal and pathological individuals, Jr. Biol. Chem., 1917, xxxii, 499. CrossrefGoogle Scholar8. ELLIS AW: Disturbance of the acid base equilibrium to the alkaline side, alkalemia, Quart. Jr. Med., 1924, xvii, 405. CrossrefGoogle Scholar9. HARROP GA: Production of tetany by intravenous infusion of sodium bicarbonate: report of adult case, Bull. Johns Hopkins Hosp., 1919, xxx, 62. GRANT, S. B.: Tetany—a report of cases with acid base disturbance, Arch. Int. Med., 1922, xxx, 355. MORSE, J. L.: An unusual case of alkalosis and impairment of the excretory power of the kidneys, New York Med. Jr., 1920, cxii, 965. Google Scholar10. PETERSVAN SLYKE JPDD: Quantitative clinical chemistry, Vol. I., Interpretations, 1931, Williams and Wilkins, Baltimore, p. 974. Google Scholar11. KIRSNERPALMER JBWL: The rôle of chlorides in alkalosis following the administration of calcium carbonate, Jr. Am. Med. Assoc., 1941, cxvi, 384. CrossrefGoogle Scholar12. HOAGWEIGELETALAMOMARPLESWOODWARD LACEHEK: Effect of therapeutic doses of sodium bicarbonate on the kidneys, Jr. Pharmacol. and Exper. Therap., 1933, xlvii, 233. Google Scholar13. KIRSNER JB: The effect of the prolonged administration of large quantities of sodium bicarbonate on the kidney of the dog, Arch. Path., 1941, xxxii, 76. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: JOSEPH B. KIRSNER, M.D., Ph.D.; WALTER LINCOLN PALMER, M.D., Ph.D., F.A.C.P.Affiliations: Chicago, Illinois*Received for publication June 21, 1941.From the Frank Billings Medical Clinic, the Department of Medicine, University of Chicago. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byAcute toxicity from baking soda ingestion5: Final Report on the Safety Assessment of Sodium Sesquicarbonate, Sodium Bicarbonate, and Sodium CarbonateEFFECT OF MASSIVE SODIUM BICARBONATE INFUSION ON RENAL FUNCTIONEFFECT OF MASSIVE SODIUM BICARBONATE INFUSION ON RENAL FUNCTION 1 January 1943Volume 18, Issue 1Page: 100-104KeywordsBicarbonatesCalciumCarbonatesIngestionPeptic ulcersSodium ePublished: 1 December 2008 Issue Published: 1 January 1943 PDF downloadLoading ...