The Improved Prognosis of Cryptococcal Meningitis with Amphotericin B Therapy
Authors: ANDERSON SPICKARD
Journal: Annals of Internal Medicine (1963)

Article1 January 1963The Improved Prognosis of Cryptococcal Meningitis with Amphotericin B TherapyANDERSON SPICKARD, M.D., WILLIAM T. BUTLER, M.D., VINCENT ANDRIOLE, M.D., JOHN P. UTZ, M.D., F.A.C.P.ANDERSON SPICKARD, M.D.Search for more papers by this author, WILLIAM T. BUTLER, M.D.Search for more papers by this author, VINCENT ANDRIOLE, M.D.Search for more papers by this author, JOHN P. UTZ, M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-58-1-66 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptCryptococcal meningitis is the most frequent cause of mycotic meningitis in man, accounting for about 10 per cent of the 300 to 400 fatal mycoses reported annually in the United States (1). The actual incidence of this type of mycotic meningitis cannot be determined accurately, but the number of case reports in the literature in recent years indicates that the disease is being recognized more frequently.The discovery of amphotericin B by Gold, Stout, Pagano, and Donovick (2) was a significant scientific achievement, for it gave to clinicians a therapeutic agent useful in a wide variety of mycotic diseases, but...References1. LITTMANZIMMERMAN MLLE: Cryptococcosis, Grune & Stratton, Inc., New York, 1956. Google Scholar2. GOLDSTOUTPAGANODONOVICK WHAJFR: Amphotericins A and B, antifungal antibiotics produced by a streptomycete. I. In vitro studies, in Antibiotics Annual, ed. by Welch, H., and Marti-Ibanez, F., Medical Encyclopedia, Inc., New York, 1956, p. 579. Google Scholar3. 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Google Scholar23. LOURIAFALLONBROWNE DBNHG: The influence of cortisone on experimental fungus infections in mice. J. Clin. Invest. 39: 1435, 1960. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: ANDERSON SPICKARD, M.D.; WILLIAM T. BUTLER, M.D.; VINCENT ANDRIOLE, M.D.; JOHN P. UTZ, M.D., F.A.C.P.Affiliations: Bethesda, MarylandFrom the Department of Health, Education, and Welfare, Public Health Service, National Institutes of Health, National Institute of Allergy and Infectious Diseases, Laboratory of Clinical Investigation, Bethesda, Maryland.Requests for reprints should be addressed to Anderson Spickard, M.D., Clinical Center, Room 11N-232, National Institutes of Health, Bethesda 14, Maryland. 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WILSON, M.D.Diagnostic and Prognostic Value of Clinical and Laboratory Findings in Cryptococcal MeningitisHistoplasma MeningitisBAYARD S. TYNES, M.D., JAMES C. CRUTCHER, M.D., JOHN P. UTZ, M.D., F.A.C.P.Systemic fungal infections amenable to chemotherapy 1 January 1963Volume 58, Issue 1Page: 66-83KeywordsAmphotericinClinical laboratoriesCorticosteroid therapyCryptococcal meningitisDrug administrationInfectious diseasesMedical servicesMeningitisMycosesResearch laboratories ePublished: 1 December 2008 Issue Published: 1 January 1963 PDF downloadLoading ...