tbuckley/cabot-search huggingface dataset:
MASSIVE LIPOID GRANULOMA OF THE LUNG AND ITS TREATMENT
Authors: S STONEHILL, G R BODON
Journal: Annals of Internal Medicine (1955)

Case Reports1 February 1955MASSIVE LIPOID GRANULOMA OF THE LUNG AND ITS TREATMENTSIDNEY STONEHILL, M.D., GEORGE R. BODON, M.D., F.A.C.S.SIDNEY STONEHILL, M.D.Search for more papers by this author, GEORGE R. BODON, M.D., F.A.C.S.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-42-2-432 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptSince Laughlen's1first report in 1925 of lipoid pneumonia in the human, many reports of this condition have appeared in the literature.2The oil (animal, vegetable or mineral) enters the lung either through direct instillation or indirectly through some defect in the swallowing mechanism, e.g., cardiospasm, neurogenic diseases, debilitated states.3The pulmonary pathology depends on the type and amount of oil that has entered the lung.4The acuteness of the lesion is dependent on the physical-chemical properties of the aspirated oil. The more inert the oil, the less acute the reaction. The lesions vary from interstitial pneumonitis to granulomatous lesions...Bibliography1. Laughlen GF: Studies on pneumonia following naso-pharyngeal injections of oil, Am. J. Path. 1: 407, 1925. MedlineGoogle Scholar2. JampolisMcDonaldClagett RWJROT: Mineral oil granuloma of the lungs: an evaluation of methods of identification of mineral oil in tissue, Surg., Gynec. and Obst. 97: 105, 1953. MedlineGoogle Scholar3. Tchertkoff IG: Lipoid pneumonia in a patient with diverticulum of the esophagus, Quart. Bull., Sea View Hosp. 7: 334, 1941-42. Google Scholar4. BergBerford HTH: Pulmonary paraffinoma (lipoid pneumonia), J. Thoracic Surg. 20: 418, 1950. CrossrefGoogle Scholar5. AndersonHolmanOlsen ABACS: Pulmonary complications of cardiospasm, J. A. M. A. 151: 608, 1953. MedlineGoogle Scholar6. Wood EH: Unusual case of carcinoma of both lungs associated with lipoid pneumonia, Radiology 40: 193, 1943. CrossrefGoogle Scholar7. Shimkin MB: Induced pulmonary tumors in mice, Arch. Path. 29: 229, 1940. Google Scholar8. TwortLyth JMR: Concentration of carcinogenic materials in minerals oils by distillation process, J. Hyg. 39: 161, 1939. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Rochester, N. Y.*Received for publication April 5, 1954.From the Department of Internal Medicine and Surgery, Rochester General Hospital, Rochester, N. Y. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byOleocysts presenting as rectal tumoursIatrogene und exogen bedingte LungenerkrankungenSampling Methods for Oil Mist in Industry 1 February 1955Volume 42, Issue 2Page: 432-438KeywordsHospital medicineInterstitial lung diseasesLesionsLungsOilsPneumoniaPulmonary diseasesRespiratory system proceduresSurgerySwallowing ePublished: 1 December 2008 Issue Published: 1 February 1955 PDF downloadLoading ...
MAJOR PSYCHOSIS IN UNDULANT FEVER
Authors: Fred E. Angle, W. H. Algie
Journal: Annals of Internal Medicine (1937)

Case Reports1 June 1937MAJOR PSYCHOSIS IN UNDULANT FEVERFRED E. ANGLE, M.D., W. H. ALGIE, M.D.FRED E. ANGLE, M.D.Search for more papers by this author, W. H. ALGIE, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-10-12-1890 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptMental symptoms have frequently been observed during the course of undulant fever. In a study of 154 cases, we have encountered only one major psychosis. We found no reference to this condition as a complication of undulant fever in the American literature. Nouvilas1 reported four cases from the Asylum of Navarre; Roger2 collected 15 cases from the literature and reported three of his own. In a series of 200 cases, Cantaloube3 reported delirium in 12 and mental confusion in ten.CASE REPORTT. H., a white male business college student, aged 23, was admitted to the hospital January 8, 1936,...Bibliography1. NOUVILAS PA: Quatro Casos de Psicosis en la Fiebre de Malta, Siglo Med., 1931, lxxxvii, 113. Google Scholar2. ROGER H: Les troubles psychiques dans la melitococcie, Marseilles Med., 1931, ii, 694. Google Scholar3. CANTALOUBE : Quoted by Roger.2 Google Scholar4. ANGLE FE: Treatment of acute and chronic brucellosis, Jr. Am. Med. Assoc., 1935, cv, 939. CrossrefGoogle Scholar5. MENNINGER WC: Severe mental disturbance associated with organic disease, Jr. Kan. Med. Soc., 1936, xxxix, 356. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Kansas City, Kansas*Received for publication January 25, 1937. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byBrucellar Psychosis 1 June 1937Volume 10, Issue 12Page: 1890-1892KeywordsDeliriumFevers ePublished: 1 December 2008 Issue Published: 1 June 1937 PDF downloadLoading ...
Abstract 14038: Multiple Infective Coronary Arteritis Complicated with Bacterial Pericarditis
Authors: Nobusada Funabashi, Hiroyuki Takaoka, Hiroyuki Takano, Takashi Kishimoto, Masanori Sano, Tomoki Yamaoka, Koya Ozawa, Yoshio Kobayashi
Journal: Circulation (2014)

A 69 year old male was referred to our institute because of dyspnea, chest compression, and fever (39.1 o C). He had had Sjögren’s syndrome, diabetes mellitus, and hypertension and had been taking a low dose of steroid orally for Sjögren’s syndrome. Serum white blood cell count and C-reactive protein were 22100/μL and 37.7mg/dl respectively. Transthoracic echocardiography revealed massive pericardial effusion and on pericardiocentesis, 200ml of purulent pericardial effusion was obtained. Pneumococcus was detected from blood culture and intravenous injection of antibiotics was started. Open-heart surgery was performed with maintenance of pericardial effusion and 300ml of purulent pericardial effusion was extracted. Inflammatory cells including neutrophils and lymphocytes were observed in the extract. On transesophageal echocardiography, presence of an abscess around the left coronary cusp was suspected and cardiac CT was performed. On CT, pericardial effusion and aneurysm with thickened wall, but without luminal stenosis in right coronary artery (RCA), aneurysm with thickened wall in left main (LM) trunk; and luminal stenosis with thickened wall in left anterior descending artery (LAD) were observed. From those findings, presence of coronary arteritis complicated with pericarditis was suspected. The patient had bloody bowel diarrhea, and colonoscopy revealed presence of colon cancer. As infection was not controlled, he died 31 days after admission. Subsequent autopsy showed macro-level findings of aneurysm with thickened wall complicated with hemorrhage in RCA and with thrombus in LM trunk. Thickened and hardened epicardium was also observed, which was in accordance with the clinical diagnosis of pericarditis. On hematoxylin and eosin staining, remarkable fibrous thickening of the intima and inflammatory cell invasion into vessel wall, mainly media, was observed. The epicardium was thickened and inflamed with fibrinous deposition.
Abstract 17260: Percutaneous Recanalization of Totally Occluded Pulmonary Veins After Pulmonary Vein Isolation
Authors: James Hill, Athar M Qureshi, Larry A Latson, Lourdes Prieto
Journal: Circulation (2011)

Background: Pulmonary vein total occlusion (PVO) is an uncommon complication of pulmonary vein isolation (PVI). We have previously published our early experience with diagnosis and treatment of PVO, and now describe mid-term follow-up of attempted recanalization. Methods: Patients with angiographic PVO were identified from our catheterization database. Medical records and catheterization reports were reviewed for: symptoms, flow to affected lung quadrant, time from PVI to diagnosis of PVO, anatomic characteristics of occluded veins, and procedural details. Patients with severely hypoplastic veins had staged intervention with initial balloon angioplasty followed by stenting 2-4 months later to allow for vessel growth. Symptoms, quadrant flow, and status of the vein at last follow-up were ascertained. Results: Between 6/2005 and 6/2011, 14 patients with PVO underwent attempted recanalization. Median age was 56.9 (0.2-67.3) years, weight 88 (5.0-111.4) kg. Symptoms included dyspnea in 11, cough in 4, hemoptysis in 5 with a mean NYHA class of 2.1 ± 0.8. Flow to affected lung quadrant was severely diminished at 5.9 ± 3.7%. Median time from PVI to recanalization attempt was 16.5 (2.0-62.7) months. Reference vessel diameter was 5.3 ± 2.0 mm and length of occluded segment 8.3 ± 6.0 mm. Recanalization results are summarized in Table 1. At median follow-up of 13.3 (0-41.3) months, 10 veins remain patent with minimal diameter of 6.1 ± 2.7 mm, reference diameter of 7.8 ± 3.1 mm, and flow to affected lung quadrant 12.3 ± 7.2%, all significantly greater than pre-intervention (p&lt;0.03). Of 10 patients completing staged intervention, 5 have no symptoms and mean NYHA class decreased to 1.5 ± 0.7. Conclusions: PVO recanalization can be accomplished with reasonable acute and mid-term vessel patency and significant improvement in symptoms and flow to affected lung quadrant. However, recurrent stenosis is common and repeated interventions are often necessary to maintain vessel patency.
Tuberculosis Among Foreign-Born Persons in the United States
Authors: Kevin P Cain, Stephen R Benoit, Carla A Winston, William R Mac Kenzie
Journal: JAMA (2008)

Foreign-born persons accounted for 57% of all tuberculosis (TB) cases in the United States in 2006. Current TB control strategies have not sufficiently addressed the high levels of TB disease and latent TB infection in this population.To determine the risk of TB disease and drug-resistant TB among foreign-born populations and the potential impact of adding TB culture to overseas screening procedures for foreign-born persons entering the United States.Descriptive epidemiologic analysis of foreign-born persons in the United States diagnosed with TB from 2001 through 2006.TB case rates, stratified by time since US entry, country of origin, and age at US entry; anti-TB drug-resistance patterns; and characteristics of TB cases diagnosed within 3 months of US entry.A total of 46,970 cases of TB disease were reported among foreign-born persons in the United States from 2001 through 2006, of which 12,928 (28%) were among recent entrants (within 2 years of US entry). Among the foreign-born population overall, TB case rates declined with increasing time since US entry, but remained higher than among US-born persons--even more than 20 years after arrival. In total, 53% of TB cases among foreign-born persons occurred among the 22% of the foreign-born population born in sub-Saharan Africa and Southeast Asia. Isoniazid resistance was as high as 20% among recent entrants from Vietnam and 18% for recent entrants from Peru. On average, 250 individuals per year were diagnosed with smear-negative, culture-positive TB disease within 3 months of US entry; 46% of these were from the Philippines or Vietnam.The relative yield of finding and treating latent TB infection is particularly high among individuals from most countries of sub-Saharan Africa and Southeast Asia.
Mutations in <i>TRPS1</i> gene in trichorhinophalangeal syndrome type I in Asian patients
Authors: L-H. Chen, C-C. Ning, S-C. Chao
Journal: British Journal of Dermatology (2010)

The trichorhinophalangeal syndromes (TRPSs) are rare hereditary diseases with mainly autosomal dominant inheritance. Three different forms sharing similar clinical features with heterogeneous mutations have been identified: type I (TRPS I), type II (TRPS II) and type III (TRPS III). These syndromes have characteristic facial abnormalities such as sparse and slow-growing scalp hair, laterally sparse eyebrows, bulbous pear-shaped nose, elongated and flat philtrum, thin upper lip, and protruding ears. Various skeletal abnormalities are also frequently noted: short stature, shortening of the phalanges and metacarpals, cone-shaped epiphyses and Perthes-like change of the hips.(1-4) The TRPS1 gene was first identified in 2000 and mapped to 8q24.1.(1) More than 50 mutations have been found in the gene to date. We here report mutation analysis of eight patients with the typical phenotype of TRPS I, revealing five novel mutations.
Abstract 18048: Short and Long Term Mortality in Women and Men Undergoing Primary Angioplasty: a Comprehensive Meta-analysis
Authors: Chirag Bavishi, Dipen Patel, Saurav Chatterjee, Vrinda Trivedi, Ashwin Sawant, Jacqueline E Tamis-Holland
Journal: Circulation (2014)

Introduction: Women with acute myocardial infarction are treated less aggressively than men and have a higher mortality. It is possible that the reported differences in outcome by sex are a result of differences in baseline risk and hospital management. We hypothesized that mortality would be similar among a cohort of women and men receiving guideline recommended reperfusion therapy for STEMI with primary PCI. Methods: We performed a meta-analysis of studies of patients with STEMI referred for primary PCI. PubMed, EMBASE and Scopus databases were searched. Studies reporting 30-day and long-term gender specific crude mortality rates and or adjusted effect estimates in STEMI patients undergoing PCI were identified. Pooled effect estimates were calculated with random effects models. Results: A total of 33 studies, involving 67,875 patients, (17,093 women and 50,782 men) were included in the analysis. As compared to men, women were older, had higher prevalence of hypertension, diabetes, hyperlipidemia, Killip &gt;1/heart failure and had lower use of aspirin, plavix and statins on discharge (p&lt;0.001 for all).Using crude rates from individual studies, women had significantly higher 30-day mortality [pooled relative risk (RR): 1.79 (1.51 -2.11), p&lt;0.001; 20 studies (n=42,749)] and long-term mortality [RR: 1.58 (1.44 -1.74), p&lt;0.001; 25 studies (n=50,552)]. When meta-analysis using multi-variable adjusted RR from individual studies was performed, 30-day mortality [RR: 1.15 (0.97 - 1.37), p =0.11; 11 studies (n=23,805)] and long-term mortality [RR: 1.02 (0.95 -1.10), p =0.58; 19 studies (n=51,124)] were no longer significantly different between women and men. Conclusions: Among STEMI patients undergoing primary PCI, short and long term mortality risk is similar in women and men after adjusting for other confounding variables. This reinforces the importance of providing evidence based reperfusion therapy to eligible women and men with acute STEMI.
Abstract 18627: Monocyte Subsets in Patients With Severe Aortic Valve Stenosis Undergoing TAVI
Authors: Bernd Hewing, Sebastian C Au, Antje Ludwig, Verena Stangl, Gert Baumann, Karl Stangl
Journal: Circulation (2014)

Introduction: Aortic valve stenosis (AVS) shares profound similarities with atherosclerotic plaque progression, including the presence of macrophages in the valve tissue. Monocytes are the precursor of macrophages and various studies have shown associations of individual monocyte subsets with cardiovascular risk. Therefore, we assessed the hypotheses that monocyte subsets differ in the presence of severe AVS compared to an AVS-free setting and change by intervention of the AVS. Methods: Classical (CD14++CD16-), intermediate (CD14++CD16+) and non-classical (CD14+CD16++) CD86 positive monocyte subsets and monocyte activation (median fluorescent intensity of CD11b) were determined by flow cytometry in peripheral blood from patients with severe AVS (n=32) and matched AVS-free controls (n=28). A follow-up evaluation of monocyte subsets and activation was performed in AVS patients undergoing transcutaneous valve implantation (TAVI) 3 months after the procedure (n=9). Results: There were no significant differences in the absolute monocyte counts between AVS patients and controls. In contrast, AVS patients exhibited a shift towards CD16+ monocytes subsets with significant higher proportion of the intermediate monocyte subset compared to controls (median [IQR] 7.0% [5.5-8.7%] versus 5.8% [4.7-6.6%]; p=0.015). Classical and non-classical monocyte subsets and monocyte activation did not differ significantly between the groups. There was no significant change in the distribution of monocyte subsets or in monocyte activation 3 months after TAVI compared to baseline. Conclusions: We found preliminary evidence for a significant difference in the distribution of monocyte subsets in patients with severe AVS compared to AVS-free controls indicating an involvement of monocyte subsets in the pathogenesis of AVS. Monocyte subsets and activation did not change after treatment of AVS by TAVI.
A case‐control study of the relation between plasma selenium and asthma in European populations: a GA<sup>2</sup>LEN project*
Authors: P. Burney, J. Potts, J. Makowska, M. Kowalski, J. Phillips, L. Gnatiuc, S. Shaheen, G. Joos, P. Van Cauwenberge, T. Van Zele, K. Verbruggen, Y. Van Durme, I. Derudder, S. Wohrl, J. Godnic‐Cvar, B. Salameh, L. Skadhauge, G. Thomsen, T. Zuberbier, K. C. Bergmann, L. Heinzerling, H. Renz, N. Al‐Fakhri, B. Kosche, A. Hildenberg, N. G. Papadopoulos, P. Xepapadaki, K. Zannikos, M. Gjomarkaj, A. Bruno, E. Pace, S. Bonini, M. Bresciani, C. Gramiccioni, W. Fokkens, E. J. M. Weersink, K.‐H. Carlsen, E. Bakkeheim, C. Loureiro, C. M. Villanueva, C. Sanjuas, J.‐P. Zock, B. Lundback, C. Janson
Journal: Allergy (2008)

Background: There is evidence that selenium levels are relatively low in Europe and may be falling. Low levels of selenium or low activity of some of the enzymes dependent on selenium have been associated with asthma. Methods: The GA 2 LEN network has organized a multicentre case–control study in Europe to assess the relation of plasma selenium to asthma. The network compared 569 cases in 14 European centres with a diagnosis of asthma and reporting asthma symptoms in the last 12 months with 576 controls from the same centres with no diagnosis of asthma and no asthmatic symptoms in the last 12 months. Results: All cases and controls were selected from the same population defined by age and place of residence. Mean plasma selenium concentrations among the controls ranged from 116.3 μg/l in Palermo to 67.7 μg/l in Vienna and 56.1 μg/l among the children in Oslo. Random effects meta‐analysis of the results from the centres showed no overall association between asthma and plasma selenium [odds ratio (OR)/10 μg/l increase in plasma selenium: 1.04; 95% confidence interval (CI): 0.89–1.21] though there was a significantly protective effect in Lodz (OR: 0.48; 95% CI: 0.29–0.78) and a marginally significant adverse effect in Amsterdam (OR: 1.68; 95% CI: 0.98–2.90) and Ghent (OR: 1.35; 95% CI: 1.03–1.77). Conclusion: This study does not support a role for selenium in protection against asthma, but effect modification and confounding cannot be ruled out.
Amplification of Long Noncoding RNA ZFAS1 Promotes Metastasis in Hepatocellular Carcinoma
Authors: Tao Li, Junjie Xie, Chuan Shen, Dongfeng Cheng, Yuan Shi, Zhichong Wu, Xiaxing Deng, Hao Chen, Baiyong Shen, Chenghong Peng, Hongwei Li, Qian Zhan, Zhecheng Zhu
Journal: Cancer Research (2015)

Despite progress in the diagnostics and treatment of hepatocellular carcinoma (HCC), its prognosis remains poor. In this study, we globally assessed long noncoding RNAs (lncRNA) for contributions to HCC using publicly available microarray data, in vitro and in vivo assays. Here, we report that ZFAS1, encoding a lncRNA that is frequently amplified in HCC, is associated with intrahepatic and extrahepatic metastasis and poor prognosis of HCC. ZFAS1 functions as an oncogene in HCC progression by binding miR-150 and abrogating its tumor-suppressive function in this setting. miR-150 repressed HCC cell invasion by inhibiting ZEB1 and the matrix metalloproteinases MMP14 and MMP16. Conversely, ZFAS1 activated ZEB1, MMP14, and MMP16 expression, inhibiting these effects of miR-150. Our results establish a function for ZFAS1 in metastatic progression and suggest its candidacy as a new prognostic biomarker and target for clinical management of HCC.
Abstract 15685: Contemporary Appraisal of the Heart Failure Epidemic, 2000-2010
Authors: Yariv Gerber, Susan A Weston, Margaret M Redfield, Alanna M Chamberlain, Sheila M Manemann, Ruoxiang Jiang, Jill M Killian, Veronique L Roger
Journal: Circulation (2014)

Background: Heart failure (HF) is commonly referred to as an epidemic posing major clinical and public health challenges. Yet, contemporary data on its magnitude and implications are scarce. We evaluated recent trends in incidence, mortality and hospitalizations in a geographically defined population. Methods: Residents of Olmsted County, Minnesota, with validated incident HF from 2000-2010 were studied. Incidence rates were calculated, overall and by preserved (HFpEF) or reduced (HFrEF) ejection fraction (EF). Outcomes included death and hospitalizations. Results: A total of 2,762 individuals had incident HF during the study period (mean age, 76 years; 43% male). The age- and sex-adjusted incidence rate of HF declined substantially [average annual percent change, -4.6; 95% confidence interval (CI): -3.5 to -5.7], equating to a 40% decline over the last decade (rate ratio 0.60; 95% CI: 0.52 to 0.69). The decline in incidence was observed for HFpEF and HFrEF and among all demographic groups, with some vari...
Palliative radiotherapy at the end of life: A critical review
Authors: Joshua A. Jones, Stephen T. Lutz, Edward Chow, Peter A. Johnstone
Journal: CA A Cancer Journal for Clinicians (2014)

Abstract Answer questions and earn CME/CNE When delivered with palliative intent, radiotherapy can help to alleviate a multitude of symptoms related to advanced cancer. In general, time to symptom relief is measured in weeks to months after the completion of radiotherapy. Over the past several years, an increasing number of studies have explored rates of radiotherapy use in the final months of life and have found variable rates of radiotherapy use. The optimal rate is unclear, but would incorporate anticipated efficacy in patients whose survival allows it and minimize overuse among patients with expected short survival. Clinician prediction has been shown to overestimate the length of survival in repeated studies. Prognostic indices can provide assistance with estimations of survival length and may help to guide treatment decisions regarding palliative radiotherapy in patients with potentially short survival times. This review explores the recent studies of radiotherapy near the end of life, examines general prognostic models for patients with advanced cancer, describes specific clinical circumstances when radiotherapy may and may not be beneficial, and addresses open questions for future research to help clarify when palliative radiotherapy may be effective near the end of life. CA Cancer J Clin 2014;64:295–310. © 2014 American Cancer Society.
Abstract 16920: Randomized, Double-Blind, Placebo Controlled Trial of Autologous CD34+ Cell Therapy for Critical Limb Ischemia: 1 Year Results
Authors: Douglas W Losordo, Melina Kibbe, Farrell Mendelsohn, William Martson, Vickie R Driver, Mel Sharafuddin, Victoria Teodorescu, Bret Wiechmann, Charles Thompson, Larry Kraiss, Teresa Carman, Suhail Dohad, Paul P Huang, John Paul Runyon, Robert M Schainfeld
Journal: Circulation (2010)