tbuckley/cabot-search huggingface dataset:
THE BILE SALTS, UREA, ETC., AS THERAPEUTIC AGENTS.Clinical Lecture delivered at the Medico-Chirurgical Hospital, Philadelphia.
Authors: SAMUEL G. DIXON
Journal: JAMA (1893)

Young men, this intrusion upon your regular cur¬ riculum of medical study just now, when you are all hard at work preparing for arduous examinations, may not permit you to welcome the remarks I have to make regarding my new treatment for tuberculo¬ sis of the skin.However, as I was once in just such a perilous situation I will be exceedingly brief, and therefore trust you will take hearty interest in this, the most momentous medical subject of the day.This expression may sound exaggerated, until you call to mind the fact that one-seventh of the deaths in the human family are caused by tuberculosis.For this reason I have devoted some years to the study of this heretofore almost unconquerable malady.I expressed, in the Medical News of October 19, 1889, a probability of producing immunity by inoculations of an involution form of the tubercle bacillus.While
Reversible Stenosis of the Saphenous Vein Graft Compressed by Giant Coronary Aneurysm in Kawasaki Disease
Authors: Yusuke Hosokawa, Takeshi Yamamoto, Katsuhito Kato, Hiromitsu Hayashi, Shunichi Ogawa, Keiji Tanaka, Kyoichi Mizuno
Journal: Journal of the American College of Cardiology (2013)
Incidence of early syphilis acquired in former Soviet Union is increasing
Authors: J. Deayton, P. French
Journal: BMJ (1997)

Editor—Since 1990 there has been a growing epidemic of syphilis in the countries of the former Soviet Union.1 The Russian health ministry recently reported a 15-fold increase in the incidence of syphilis in adults and a 20-fold increase in children.2 Most cases are attributed to sexual transmission. Explanations for this phenomenon include the rapid growth of the sex industry, including child prostitution; increasing numbers of homeless people and refugees in Russian cities; poor diagnostic facilities;punitive legislation …
Transepithelial transport of epidermal growth factor by absorptive cells of suckling rat ileum.
Authors: P A Gonnella, K Siminoski, R A Murphy, M R Neutra
Journal: Journal of Clinical Investigation (1987)

Epidermal growth factor (EGF), an acid-stable peptide present in rodent and human milk, is absorbed and promotes intestinal growth when fed to suckling rats. To determine whether absorptive cells of suckling rat ileum conduct selective transepithelial transport of EGF, we followed uptake of 125I-EGF from ileal loops by autoradiography and biochemical methods. Specific binding sites for 125I-EGF were localized by electron microscope autoradiography on apical membranes of ileal epithelial sheets in vitro. During uptake in vivo, radiolabeled molecules were concentrated in apical endosomal compartments and were also associated with lysosomal vacuoles, basolateral cell surfaces, and lamina propria. Excess cold EGF reduced basolateral label by 44% and TCA precipitable serum label by 38%. After 30 and 60 min of continuous uptake, radiolabeled molecules in epithelium, denuded mucosa, blood, and liver were analyzed under reducing conditions by reversed-phase high-pressure liquid chromatography (HPLC) and sodium dodecyl sulfate-polyacrylamide gel electrophoresis (SDS-PAGE). Although considerable degradation of 125I-EGF occurred after uptake from the lumen, a portion of radiolabel in epithelium and mucosa represented 125I-EGF which eluted somewhat more rapidly from C18 HPLC columns and showed a slight decrease in apparent molecular weight by SDS-PAGE. All radiolabel in blood and liver represented breakdown products. Thus, EGF is selectively transported across the ileal epithelium in suckling rats but is modified during transport. Milk EGF may accumulate in the lamina propria where it could influence growth and maturation of the suckling intestine.
US flight attendants win settlement over passive smoking
Authors: D. Josefson
Journal: BMJ (1997)

In a landmark trial on second hand smoke 60 000 flight attendants have wrested a historic settlement from five major tobacco companies.

The flight attendants had filed a class action suit charging that they had suffered smoking related illnesses from being subjected to high concentrations of environmental smoke and seeking $5bn (£8bn) in damages. The companies on trial were Philip Morris, R J Reynolds, Brown and Williamson, the Liggett Group, and the Lorillard Group. Also named in the suit were two lobbying groups funded by the …
Social learning and amygdala disruptions in Nf1 mice are rescued by blocking p21-activated kinase
Authors: Andrei I Molosh, Philip L Johnson, John P Spence, David Arendt, Lauren M Federici, Cristian Bernabe, Steven P Janasik, Zaneer M Segu, Rajesh Khanna, Chirayu Goswami, Weiguo Zhu, Su-Jung Park, Lang Li, Yehia S Mechref, D Wade Clapp, Anantha Shekhar
Journal: Nature Neuroscience (2014)
Skin surgeon who obtained false reference from GP friend is struck off
Authors: C. Dyer
Journal: BMJ (2015)

A plastic and dermatological surgeon who persuaded a GP friend in Ireland to write a false work reference for him has been struck off the UK medical register.

Farrukh Butt, 54, who qualified in Pakistan and worked for 17 years in Ireland, obtained a locum consultant post at Leeds General Infirmary by using a misleading curriculum vitae, but he soon committed a string of surgical errors that were “inconsistent with a doctor performing at the level of a consultant,” a panel of the …
Incidence of risk factors for myocardial infarction and other vascular diseases in patients with psoriasis
Authors: J.A. Kaye, L. Li, S.S. Jick
Journal: British Journal of Dermatology (2008)

Recent cross-sectional studies reported a higher prevalence of diabetes and other risk factors for cardiovascular disease in patients with psoriasis than in the general population.To estimate the cumulative incidences of risk factors for myocardial infarction and other vascular diseases after a first recorded diagnosis of psoriasis and the hazard ratio (HR) for these conditions in patients with psoriasis compared with the general population.We used the General Practice Research Database to conduct a cohort study of 44,164 patients with a first-time diagnosis of psoriasis and 219,784 nonpsoriasis comparison subjects psoriasis-matched on age, sex and index date.HRs were increased among patients with psoriasis vs. the comparison cohort for incident diabetes [HR 1.33; 95% confidence interval (CI) 1.25-1.42], hypertension (HR 1.09; 95% CI 1.05-1.14), obesity (HR 1.18; 95% CI 1.14-1.23) and hyperlipidaemia (HR 1.17; 95% CI 1.11-1.23). Patients with psoriasis also had higher risks of incident myocardial infarction (HR 1.21; 95% CI 1.10-1.32), angina (HR 1.20; 95% CI 1.12-1.29), atherosclerosis (HR 1.28; 95% CI 1.10-1.48), peripheral vascular disease (HR 1.29; 95% CI 1.13-1.47) and stroke (HR 1.12; 95% CI 1.00-1.25).Risk factors for cardiovascular disease as well as myocardial infarction and other vascular diseases occur with higher incidence in patients with psoriasis than in the general population. Further work is needed to investigate whether these associations involve causal factors related to psoriasis or its treatment.
Response to Letter Regarding Article, “Left Ventricular Dyssynchrony Is Mandatory for Response to Cardiac Resynchronization Therapy”
Authors: Gabe B. Bleeker, Sjoerd A. Mollema, Eduard R. Holman, Nico Van De Veire, Claudia Ypenburg, Ernst E. van der Wall, Martin J. Schalij, Jeroen J. Bax, Eric Boersma
Journal: Circulation (2008)
Pharmacokinetics of IgPro20 after Subcutaneous Administration in Patients with Primary Immunodeficiency
Authors: J.A. Church, I. Melamed, R.P. Nelson, A.P. Knutsen, M.B. Fasano, M.R. Stein, M.A. Rojavin, P.C. Kiessling, R.L. Wasserman
Journal: Journal of Allergy and Clinical Immunology (2010)
596 TARGETING OF LYSYL OXIDASE-LIKE-2 (LOXL2) PROMOTES REVERSAL OF LIVER FIBROSIS VIA INHIBITION OF COLLAGEN CROSS-LINKING AND FIBROTIC MATRIX STABILIZATION
Authors: N. Ikenaga, S. Yoshida, S.B. Liu, J. Chung, D. Sverdlov, D. Marshall, V. Smith, M. Kovalenko, S. Karnik, N. Afdhal, Y. Popov
Journal: Journal of Hepatology (2013)
Dressage for Cardiologists: Gallop or Canter?
Authors: Frederick W. Hund
Journal: JAMA (1989)

To the Editor.—  In his 1894 textbook, Potain, 1 taught by Bouillaid, described the bruit de galop, an abnormal heart sound causing a rhythm that he likened to the sound of galloping horses: Fort analogue au bruit des chevaux que nous entendons chaque jour galoper dans les rues ou sur la promenade. Today, gallop is regularly used to mean triple or quadruple cardiac rhythms. This is incorrect.  Among equestrians, gallop has a precise meaning: it denotes the faster, four-beat gait, in which each hoof lands separately. When the gallop is slowed and shortened (collected in equestrian terminology), it becomes the canter, a three -beat gait in which a forefoot and the opposite hindfoot land simultaneously. This distinction is clear in the literature of both classical horsemanship 2 and veterinary medicine. 3 Indeed, in dressage, the most ancient and advanced form of equitation, it is considered a serious fault to perform
Endoscopic removal of proximally migrated pancreatic stent by a grasping tripod
Authors: R. Rerknimitr, W. Phuangsombat, P. Naprasert
Journal: Endoscopy (2007)

A 30-year-old man was referred for an endoscopic removal of proximally migrated pancreatic stent. At our institution, the initial attempt by endoscopic removal using a snare, basket and balloon extraction failed. The distal tip of the stent was impacted at the side wall of the pancreatic duct. A rat-tooth forceps was also tried and was able to access the tip of the stent. Unfortunately, it could not be opened fully due to the small size of the pancreatic duct. During subsequent endoscopic retrograde cholangiopancreatography, a Caesar grasping tripod (Wilson-Cook, Winston-Salem, North Carolina) was used. Within the first attempt, the tripod was able to grasp the tip of the stent firmly enough to allow stent removal (Figure [1] and [2]).
The Limits of Reductionism in Medicine: Could Systems Biology Offer an Alternative?
Authors: Andrew C Ahn, Muneesh Tewari, Chi-Sang Poon, Russell S Phillips
Journal: PLoS Medicine (2006)

In the first of a two part series, Ahn and colleagues discuss the reductionist approach pervading medicine and explain how a systems approach (as advocated by systems biology) may complement reductionism.
Can Access Be Improved While Controlling Costs?
Authors: William Campbell Felch
Journal: JAMA (1987)

On the surface, this book is a straightforward, in-depth evaluation of a major health care provision project carried out in five cities between 1978 and 1984. But behind its cold tables and statistics, a reader gets a sense of the human values invested in the project, of the hopes— and disappointments—that accompanied it. The dream was a noble one, posing the question: Can a better way be found for providing health services to the inner-city poor? The stimulus for the Municipal Health Services Program (MHSP) project came, like many other good ideas these days, from the Robert Wood Johnson Foundation, which contributed $3 million to each of five sites for the planning and start-up costs of establishing inner-city primary care centers. A second funding source was the Health Care Financing Administration, which arranged for a waiver program that would encourage people to use the primary care centers (by forgiving the
A Practice of Anesthesia for Infants and Children
Authors: Brenda C. McClain
Journal: JAMA (2010)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Singaporean medical team reports back from Burma
Authors: David Brill
Journal: BMJ (2008)

Although some humanitarian organisations are still encountering obstacles in providing aid to the survivors of the cyclone that hit Burma in May, a team of doctors and nurses from Singapore has been able to treat some 5000 patients.

The team of 23, now back home, was based for two weeks at a hospital in the township of Twan Te, roughly an hour’s drive south west of Rangoon. Dispatched under three separate banners—the Ministry of Health, the Singapore Red Cross, and a non-governmental humanitarian charity called Mercy Relief—they united on arrival to share expertise and resources.

Some international aid had reached the people of Twan Te, many of whom are living in tented refugee camps with access to water filtration systems donated from overseas. Other residents had taken shelter in the town’s monasteries.

Rebuilding of damaged houses has already begun, the Singaporean team says. Many …
PERCUTANEOUS EPICARDIAL ABLATION OF VENTRICULAR TACHYCARDIA AFTER FAILURE OF ENDOCARDIAL APPROACH IN THE PEDIATRIC POPULATION WITH ARRHYTHMOGENIC RIGHT VENTRICULAR DYSPLASIA
Authors: Evgeny Pokushalov, Aleksandr Romanov, Sergey Artemenko, Alex Turov, Nataliya Shirokova, Aleksandr Karaskov
Journal: Journal of the American College of Cardiology (2011)
Malformation of the Head in the F tus
Authors: H. G. Trend
Journal: BMJ (1857)

tion of' urineb lhad now tak-en place, after a complete cessationi of forty-eigiht liours.TIr.inad, in fact recovered.R ArKl,xZs.The foregoing particulars I leave with you.I offer you them in earnestness, an(d vet with all deferenceo to the individnat experience an(d conclus-ions of gentlemen pres-ent.l'ray lo not prujudge this question of the treatment, of chiolera; it is one of great miportance, inivolving as it (loes the healthi and life of very inany now living, andt of couinitless thouisanids yet nciborn.lbe assured tbitit chloilera staitisti's are, 1up) to this time, in maniy respects valueless.You will liave seen elaborate tables;, lonig drawnti out, prepared to sliow the comparaLtive failure of tllk elilmlinative trealtment of thlis foarful nmaladly; but I would ask y0 ou to renienrbr tlhaIt the castor oil treatment is inot the legitimate " eliminative" treatment.Such dtoes not constituite the treatment by purgatives, as the ftoegoing case (letailed to you so completely ndzl sucecesst'ully realises.Trhe statistics of clholera remain to this time to be dlemonistrated.
R-binder deficiency. A clinically benign cause of cobalamin pseudodeficiency
Authors: R. Carmel
Journal: JAMA (1983)

A patient with R-binder deficiency lacked this cobalamin-binding protein in serum, saliva, gastric juice, and leukocytes, as demonstrated by cobalamin-binding ability and radioimmunoassay. The patient's condition was first detected because of a low serum cobalamin (vitamin B12) level. His level of serum cobalamin, however, which was carried largely by transcobalamin II, was not as decreased as in the initial cases reported and was higher by some assays than by others. The demonstration of normal bone marrow morphological appearance and deoxyuridine suppression test findings, lack of attributable neurological dysfunction, and absence of methylmalonic aciduria make clear that deficiency of R binder, whose function is unknown, did not produce notable disturbance of cobalamin metabolism. This entity is probably not as rare as originally thought. It must be considered in the differential diagnosis of low serum cobalamin levels, even among elderly patients, whose conditions often tend to be automatically diagnosed as pernicious anemia.
Abstract 5473: Antiproliferative and antimetastasic activity of a novel vasopressin V2 receptor peptide agonist in a breast cancer model
Authors: Giselle V. Ripoll, Juan Garona, Nancy Iannucci, Ulises Orlando, Osvaldo Cascone, Ernesto Podestá, Daniel E. Gomez, Daniel F. Alonso
Journal: Cancer Research (2010)

Abstract Desmopressin (1-deamino-8-D-arginine vasopressin) is a synthetic analog of vasopressin with antimetastatic properties. The molecule is a well known and safe hemostatic compound that acts as a selective agonist for the vasopressin V2 membrane receptor, which is expressed in endothelium and also in some tumor cells. Previous data revealed that perioperative administration of desmopressin can minimize the spread and survival of residual cancer cells. This cyclic nonapeptide was substituted in positions 4 and 5 searching for compounds with improved biological activity and half life. Such positions belong to the disulphide loop (between positions 1-6), which have a major interaction with its receptor. In this work, we evaluated the in vitro biological activity of a novel analog designated VQ (1-deamino-4-valine-5-glutamine-8-D-arginine vasopressin) in MCF7 human mammary carcinoma cells, as well as its in vivo antitumor action in combination with chemotherapy using the syngeneic F3II mammary carcinoma model in Balb/c mice. Because V2 receptor signaling has been associated with cytostatic effects, we have examined peptide ability to modify in vitro cell proliferation of MCF7 cells expressing V2 receptor. Incubation with VQ analog (100-1500 nM) during 72 h significantly reduced cell proliferation (p&amp;lt;0.001) showing a better performance than desmopressin at higher doses of 500-1500 nM (p&amp;lt;0.05). Inhibition of cell proliferation was associated with an increase of intracellular cAMP levels and this was correlated with PKA activation in MCF7 cells. A similar antiproliferative profile was obtained with loop tetrapeptides (aminoacid positions 2-5) at low doses (&amp;lt;500 nM), although cytostatic activity of tetrapeptides was lost at high concentrations. Three weekly i.v. doses of VQ (0.3 µg/kg/dose) reduced by 40% the subcutaneous tumor volume in mice implanted with F3II mammary carcinoma cells, while VQ treatment plus weekly i.p. cycles of carmustine (20 mg/kg/cycle) was even more effective (p&amp;lt;0.001). Furthermore, VQ treatment, either in combination or not with carmustine cycles, prevented lung metastatic progression in tumor-bearing mice. VQ also inhibited F3II lung colonization in the experimental metastasis assay. Our results indicate that the novel cyclic peptide analog VQ can exert a remarkable antitumor and antimetastatic effect in a preclinical model of breast carcinoma. Loop conformation of the peptide seems to be essential for interaction with V2 receptor and for the biological activity of the compound. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 101st Annual Meeting of the American Association for Cancer Research; 2010 Apr 17-21; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2010;70(8 Suppl):Abstract nr 5473.
Caring for the Poor
Authors: John M. Cox
Journal: JAMA (1988)

To the Editor.—  I read with shock and dismay the Letter to the Editor by Dr Weaver1published in the April 15 issue ofJAMA, in reply to the article by Dr Lundberg and Mr Bodine.2In Dr Weaver's letter, he describes the indigent as derelicts and bums. He also accuses them of being drunks, addicts, illiterates, beggars, and thieves. I, frankly, am appalled that a physician would have such an opinion about the poor of this country and I am amazed that he is willing to voice his opinion in public in the form of a letter to the editor..  Unfortunately, the attitude that the poor and illiterate are that way by lack of effort on their part is an attitude that has been too often repeated by our present administration in Washington. While it is true that some individuals are impoverished owing to their own lack
Cyclin kinase inhibitors are increased during experimental membranous nephropathy: Potential role in limiting glomerular epithelial cell proliferation in vivo
Authors: Stuart J. Shankland, Jürgen Floege, Susan E. Thomas, Masaomi Nangaku, Christian Hugo, Jeffrey Pippin, Kevin Henne, David M. Hockenberry, Richard J. Johnson, William G. Couser
Journal: Kidney International (1997)
Commercial funding of accredited continuing medical education
Authors: J. A. Tabas, R. B. Baron
Journal: BMJ (2012)

Is decreasing but more needs to happen 

Funding from the drug industry and manufacturers of medical devices supports a large proportion of costs for accredited continuing medical education (CME) in the United States. However, newly released data from the Accreditation Council for Continuing Medical Education (ACCME) show that funding for CME from drug companies and medical device makers (including advertising and exhibit income) fell in 2010 to $1.1bn (£0.7bn; €0.84bn), the third consecutive annual decline from a high of $1.5bn in 2007, and the lowest figure since 2002.1 The proportion of total CME funding from commercial support, advertising, and exhibit income has steadily decreased from a high of 62% in 2004 to the current rate of 49%.

In recent years, there has been increasing debate among the public and medical profession about the role of industry funding in medical education. Several prominent organisations—including the Association of American Medical Colleges, the Institute of Medicine, and the Josiah Macy Jr Foundation—have called for limits to the amounts and scope of commercial support for …
Protective effect of preconditioning on reperfusion induced ventricular arrhythmias of isolated rat hearts
Authors: M. Osada, T. Sato, S. Komori, K. Tamura
Journal: Cardiovascular Research (1991)

Study objective — The aim was to investigate the effect of preconditioning on reperfusion induced arrhythmias in the isolated working rat heart. Design — Rat hearts were perfused with modified Krebs-Henseleit bicarbonate buffer. A 15 min period of global ischaemia was performed followed by a reperfusion period of 5 min. This procedure was repeated three times. Hearts were divided into the control group (n = 10) and the free radical scavenger group (n = 11). Hearts in the latter were reperfused in the presence of scavengers (SOD 3.5 × 104U·litre−1 and catalase 5.0 × 105 U·litre−1). Experimental material — Hearts were obtained from male Sprague-Dawley rats (270-350 g). Measurements and main results — The incidence of reperfusion induced ventricular fibrillation in the control group decreased from 100% to 70% (NS) and to 40% (p<0.01) during the second and the third reperfusion periods, respectively. In the scavenger group, the incidence of ventricular fibrillation was the same in each reperfusion period at 45%. The time to onset of ventricular fibrillation increased at the second reperfusion in both groups. Conclusions — (1) The protective effect of preconditioning on reperfusion induced arrhythmia is evident in the isolated rat heart. (2) Addition of free radical scavengers reduced the incidence of reperfusion arrhythmia. However, the protective effect of preconditioning was lost.