tbuckley/cabot-search huggingface dataset:
Skin equivalents: skin from reconstructions as models to study skin development and diseases
Authors: N. Ali, M. Hosseini, S. Vainio, A. Taïeb, M. Cario‐André, H.R. Rezvani
Journal: British Journal of Dermatology (2015)

While skin is readily available for sampling and direct studies of its constituents, an important intermediate step is to design in vitro and/or in vivo models to address scientific or medical questions in dermatology and skin biology. Pioneered more than 30 years ago, human skin equivalents (HSEs) have been refined with better cell culture techniques and media, together with sophisticated cell biology tools including genetic engineering and cell reprogramming. HSEs mimic key elements of human skin biology and have been instrumental in demonstrating the importance of cell-cell interactions in skin homeostasis and the role of a complex cellular microenvironment to coordinate epidermal proliferation, differentiation and pigmentation. HSEs have a wide field of applications from cell biology to dermocosmetics, modelling diseases, drug development, skin ageing, pathophysiology and regenerative medicine. In this article we critically review the major current approaches used to reconstruct organotypic skin models and their application with a particular emphasis on skin biology and pathophysiology of skin disorders.
Thornton's Medical Books, Libraries and Collectors: A Study of Bibliography and the Book Trade in Relation to the Medical Sciences
Authors: John Leonard Thornton
Journal: Annals of Internal Medicine (1992)

Medical books before the invention of printing, P.M.Jones medical incunabula, D.E.Rhodes medical books of the 16th century, Y.Hibbott 17th century medical books, C.R.English medical books from 1701-1800, P.C.Want medical books of the 19th century, G.Davenport the growth of medical periodical literature, L.T.Morton medical bibliographies and bibliographers, J.Symons private medical libraries, A.Besson medical libraries of today, R.B.Tabor.
Dynamics in cytokine responses during the development of occupational sensitization to rats
Authors: E. J. M. Krop, M. A. Van De Pol, R. Lutter, D. J. J. Heederik, R. C. Aalberse, J. S. Van Der Zee
Journal: Allergy (2010)

Occupational allergy forms an attractive model to study the development of allergic responses, as in some occupations it has a high incidence and develops quickly. In a cohort of starting laboratory animal workers, we previously found 20% sensitization to animal allergens within 2 years.We compared cellular responses of incident laboratory animal workers who developed rat-specific sensitization (cases, n = 18) during 2 years of follow-up to control animal workers matched for atopic status but without sensitization after follow-up (controls, n = 18). Practically, this is a case-control study, nested within the cohort. Rat-specific IgE antibodies were measured in sera, and allergen-specific and nonspecific cytokine responses were measured in whole blood and in isolated peripheral blood mononuclear cells.Self-reported allergic symptoms were related to the presence of rat-specific IgE (P ≤ 0.01). Cases developed a rat allergen-specific interleukin (IL)-4 response during sensitization, while controls did not show an increased IL-4 response (at visit D: 33 vs 5 IL-4 producing cells/10(6) cells, P < 0.001). The IL-4 response was related to the levels of rat-specific IgE in cases (visit D: rho = 0.706, P < 0.001). By contrast, allergen-specific IL-10 and interferon γ (IFNγ) responses as well as nonspecific cytokine responses were comparable between cases and controls.This study is the first to show the development of an allergen-specific IL-4 response in adult human subjects during allergen-specific sensitization. This IL-4 response was quantitatively associated with the development of the specific IgE antibodies. Allergen-specific or nonspecific IL-10 and IFNγ responses showed no protective effect on the development of allergic sensitization.
Myofunctional treatment of sleep disordered breathing in children
Authors: Brasili Luca, Susy Martella, Ottavio Vitelli, Carlotta Bianchini, Silvia Miano, Alessandro Ferretti, Marco Del Pozzo, Maria Pia Villa
Journal: European Respiratory Journal (2013)

Introduction:  Notwithstanding adenotonsillar hypertrophy is the main causative factor of pediatric obstructive sleep apnea (OSA), a residual OSA after adenotonsillectomy (AT) is often reported and we hypothesise that oropharyngeal hypotonia is implicated in the pathogenesis of OSA and oropharingeal exercises (myofunctional therapy) may improve stomatognathics functions and reduce neuromuscular impairment.   Aim:  To evaluate efficacy of myofunctional treatment in children with residual OSA.   Methods:  Polysomnographic recordings have been performed before the surgical therapy (T0) and 6 months after AT (T1). Thereafter, patients with a residual OSA (apnea hypopnea index, AHI>1) have been randomized in a group treated with myofunctional therapy (group 1) and a control group (group 2). A morphofunctional evaluation with Glatzel and Rosenthal tests were performed before (T1) and after 3 months of exercises (T2). All subjects were reevalueted at T2.  The improvement of OSA was defined by ΔAHI: (AHI at T1-AHI at T2)/AHI at T1*100.   Result   Group 1 was composed by 12 subjects (males 10; mean age 5.37 ± 1.71) and Group 2 was composed by 9 subjects (males 8; mean age 4.25 ± 0.39). The AHI was 16.31 ± 9.51 in T0 ad 3.46 ± 2.32 in T1 (p  The ΔAHI was significantly higher (p  Myofunctional evaluation demonstrated: reduction of oral breathing (12/12 vs 3/12, p   Conclusion   Myofunctional therapy could be an efficacious treatment in pediatric OSA in addition to AT.
Is a Pre-Operative Brain Natriuretic Peptide or N-Terminal Pro–B-Type Natriuretic Peptide Measurement an Independent Predictor of Adverse Cardiovascular Outcomes Within 30 Days of Noncardiac Surgery?
Authors: Ganesan Karthikeyan, Ross A. Moncur, Oren Levine, Diane Heels-Ansdell, Matthew T.V. Chan, Pablo Alonso-Coello, Salim Yusuf, Daniel Sessler, Juan Carlos Villar, Otavio Berwanger, Matthew McQueen, Anna Mathew, Stephen Hill, Simon Gibson, Colin Berry, Huei-Ming Yeh, P.J. Devereaux
Journal: Journal of the American College of Cardiology (2009)
SALMONELLOSIS: NINE CASES SUCCESSFULLY TREATED WITH CHLOROMYCETIN
Authors: J H DORAN
Journal: Annals of Internal Medicine (1952)

Article1 October 1952SALMONELLOSIS: NINE CASES SUCCESSFULLY TREATED WITH CHLOROMYCETINJ. HAL DORAN, M.D.J. HAL DORAN, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-37-4-714 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptSalmonella infections in the United States today still present major problems to the medical profession. The variety of species and the protean nature of the organisms are prime factors in the problem, over 150 different organisms having been described to date. All of these are pathogenic for both men and animals, and can be transmitted from man to man by direct contact, by food contaminated by handlers, improper cooking of infected meat and fowl, foods such as creamy pastries, pies, ice-cream, mayonnaise, eggs (fresh, powdered and frozen), and by mechanical vectors such as fleas and other insects, by contaminated water...Bibliography1. FelsenfeldYoung OUM: Geography of salmonellosis, Am. J. Digest. Dis. 14: 47-52 (Feb.) 1947. CrossrefMedlineGoogle Scholar2. EdwardsBrunerMoran PRDWAB: Further studies on the occurrence and distribution of salmonella types in the United States, J. Infect. Dis. 83: 220-231 (Nov.-Dec.) 1948. CrossrefMedlineGoogle Scholar3. Lomberg F: Actions of sodium and magnesium sulfate on salmonellae, shigellae, and vibrios, Am. J. Digest. Dis. 17: 38-39 (Feb.) 1950. CrossrefMedlineGoogle Scholar4. JacksonGockeCollinsFinland GGTMHSM: In vitro sensitivity of pathogenic enteric bacteria to various antibiotics, J. Infect. Dis. 87: 63-78 (July-Aug.) 1950. CrossrefMedlineGoogle Scholar5. KurzCrehanThomson ERELC: Salmonella endocarditis with streptomycin failure, Ann. Int. Med. 31: 497-503 (Sept.) 1949. LinkGoogle Scholar6. FelsenfeldVoliniGonzalez OIFLM: The sensitivity of salmonellae and shigellae to streptomycin, Am. J. Digest. Dis. 17: 108-110, 1950. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Indianapolis, Indiana*Received for publication May 5, 1952.†U. S. Public Health Service, Communicable Disease Center, Chamblee, Georgia. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byInfection with Salmonella TennesseeCurrent pediatric references 1 October 1952Volume 37, Issue 4Page: 714-722KeywordsFleasFoodMeatMedical servicesPathogensSalmonellaSalmonellosis ePublished: 1 December 2008 Issue Published: 1 October 1952 PDF downloadLoading ...
Determination of the Histocompatibility Locus Involved in the Resistance of Mice of Strains C57BL/10-&lt;italic&gt;x&lt;/italic&gt;, C57BL/6-&lt;italic&gt;x&lt;/italic&gt;, and C57BL/6Ks to C57BL Tumors&lt;xref ref-type="fn" rid="fn1"&gt;2&lt;/xref&gt;
Authors: G. D. Snell, P. R. F. Borges
Journal: JNCI Journal of the National Cancer Institute (1953)

Determination of the Histocompatibility Locus Involved in the Resistance of Mice of Strains C57BL/10-x, C57BL/6-x, and C57BL/6Ks to C57BL Tumors Get access G. D. Snell, G. D. Snell Roscoe B. Jackson Memorial Laboratory, Bar Harbor, Maine Search for other works by this author on: Oxford Academic PubMed Google Scholar P. R. F. Borges P. R. F. Borges Roscoe B. Jackson Memorial Laboratory, Bar Harbor, Maine Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 14, Issue 3, December 1953, Pages 481–484, https://doi.org/10.1093/jnci/14.3.481 Published: 01 December 1953 Article history Received: 15 June 1953 Published: 01 December 1953
Bilirubin and the Most Highly Associated Variant are Associated with the Risk of Incident Type 2 Diabetes in the Community: A Mendelian Randomization Approach
Authors: Ali Abbasi, Eva Corpeleijn, Ronald Gansevoort, Reinold Gans, Hans L. Hillege, Pim van der Harst, Ronald P. Stolk, Gerarda Navis, Stephan J. Bakker
Journal: Circulation (2013)

Background: A higher circulating bilirubin, as an antioxidant, has been shown to be associated with a lower risk of cardiometabolic traits/diseases. We aimed to prospectively investigate the association of serum bilirubin and the most highly associated variant in UGT1A1 locus (rs6742078) with the risk of future diabetes in the community. We performed a mendelian randomisation approach to examine the hypothesis that the association of serum bilirubin with diabetes is causal.

Methods: We performed prospective cohort analysis in 3,381 participants free of diabetes (aged 28-75 years; women 52.6%) from the Prevention of Renal and Vascular End-stage Disease (PREVEND) study in Groningen, the Netherlands. We genotyped the variant rs6742078 within the gene region encoding hepatic enzyme, UDP glucuronosyltransferase 1 family, polypeptide A1 (UGT1A1). We examined the association of serum bilirubin and the variant rs6742078 with risk of diabetes in multivariable-adjusted logistic regression model for the KORA clinical diabetes score including data on age, sex, BMI, smoking, hypertension, family history of diabetes and glucose. Using rs6742078 allele as an instrument variable in mendelian randomization approach, the expected risk of diabetes per 1-SD increase in log-transformed bilirubin levels was calculated as: exp (ln(OR diabetes-genotupe)/ s coefficient bilirubin-genotype)).

Results: A total of 210 (6.2%) participants developed diabetes during a median follow-up of 7.8 years. Bilirubin level was strongly associated with rs6742078, -0.68 SD change in log-transformed level with each copy of risk allele (P< 1×10 -122). In multivariable-adjusted model, we observed a 44% (OR=1.44, 95%CI, 1.11-1.86; P=0.006) higher risk of incident diabetes with each copy of risk allele. In multivariable-adjusted model, we observed a 25% (OR=0.75, 95%CI, 0.62-0.92; P=0.004) lower risk of incident diabetes per 1-SD increase in log-transformed bilirubin levels. In mendelian randomization approach, the expected risk of diabetes was 22.2% lower per 1-SD increase of log-transformed bilirubin levels. We observed no associations between confounders and the variant rs6742078.

Conclusions: Both serum bilirubin and the variant rs6742078 in UGT1A1 locus are strongly associated with the risk of developing diabetes. Based on our findings, it seems that bilirubin signalling may have causal role in the development of diabetes. Further studies are warranted to confirm this and translate into practice, such as early screening and prevention.
Drug points: Hypersensitivity to retinol palmitate injection
Authors: W B Shelley, E D Shelley, N Y Talanin
Journal: BMJ (1995)

Professors W B SHELLEY and E D SHELLEY and Assistant Professor N Y Talanin (Department of Medicine, Medical College of Ohio, PO Box 10008, Toledo, Ohio 43699-0008, USA) write: McCormick reported local inflammatory reactions after intramuscular injections of vitamin A and concluded that the vehicles used to make vitamin A water soluble were responsible.1 Our observations show that vitamin A (retinol) can itself cause an inflammatory hypersensitivity reaction.

A 66 …
LEF-1 is crucial for neutrophil granulocytopoiesis and its expression is severely reduced in congenital neutropenia
Authors: Julia Skokowa, Gunnar Cario, Murat Uenalan, Axel Schambach, Manuela Germeshausen, Karin Battmer, Cornelia Zeidler, Ulrich Lehmann, Matthias Eder, Christopher Baum, Rudolf Grosschedl, Martin Stanulla, Michaela Scherr, Karl Welte
Journal: Nature Medicine (2006)
Factors associated with growth and blood pressure patterns in children with sickle cell anemia: Silent Cerebral Infarct Multi‐Center Clinical Trial cohort
Authors: Rachel B. Wolf, Benjamin R. Saville, Dionna O. Roberts, Rachel B. Fissell, Adetola A. Kassim, Gladstone Airewele, Michael R. DeBaun
Journal: American Journal of Hematology (2014)

Individuals with sickle cell anemia (SCA) exhibit delayed growth trajectories and lower blood pressure (BP) measurements than individuals without SCA. We evaluated factors associated with height, weight, and BP and established reference growth curves and BP tables using data from the Silent Cerebral Infarct Multi-Center Clinical (SIT) Trial (NCT00072761). Quantile regression models were used to determine the percentiles of growth and BP measurements. Multivariable quantile regression was used to test associations of baseline variables with height, weight, and BP measurements. Height and weight measurements were collected from a total of 949 participants with median age of 10.5 years [Interquartile range (IQR) 8.2-12.9] and median follow-up time of 3.2 years (IQR 1.8-4.7, range 0-12.9). Serial BP measurements were collected from a total of 944 and 943 participants, respectively, with median age of 10.6 years (IQR = 8.3-12.9 years), and median follow-up time of 3.3 years (IQR = 1.7-4.8). Multivariable quantile regression analysis revealed that higher hemoglobin measurements at baseline were associated with greater height (P < 0.001), weight (P = 0.000), systolic BP (P < 0.001), and diastolic BP (P = 0.003) measurements. We now provide new reference values for height, weight, and BP measurements that are now readily available for medical management.
Calnexin dendritic vaccine and tumor vaccine for canine transmissible venereal tumor in the canine model
Authors: Reamin Chu, Chuang Tienfu, Chen LiyYin
Journal: Clinical Cancer Research (2007)

AACR Centennial Conference: Translational Cancer Medicine-- Nov 4-8, 2007; Singapore

C27 

Surgery and chemotherapy are standard treatments of canine cancers, but tumors commonly have a high rate of relapse. Dendritic cells (DC) vaccine and tumor vaccine are new treatment options for tumor diseases. Calnexin (CNX) is an endoplasmic reticulum chaperone and is identified as a protein involving in the production of MHC class I molecules. The antitumor efficiency of autologous DC and canine transmissible venereal tumor (CTVT) transduced with a lentiviral vector expressing CNX and were evaluated in a CTVT model. Four subcutaneous administration of CNX gene-modified DC and tumor cells led to marked tumor growth suppression with intratumoral lymphocytic infiltration. DC vaccine is more effective than tumor vaccine in the supression of established tumors. The surface expression of MHC I and II molecules of CTVT cells was significantly increased after these therapies. By ELISpot technique, the CNX therapy groups in DC or tumor vaccine therapy revealed a significantly greater frequency of tumor-specific T cells that released IFN-γ compared with the controls. The specific T-cell antitumor responses were significantly increased following the therapy but the innate natural killer antitumor responses were not. In addition, the DC vaccine and tumor vaccine therapies did not present with any apparent adverse effects. These results demonstrated that both DC and tumor vaccine for CTVT in vivo using calnexin were efficient in suppressing dog tumor and can be considered as another choice in treating canine cancers.
Association between atopic dermatitis and obesity in adulthood
Authors: J.I. Silverberg, N.B. Silverberg, M. Lee-Wong
Journal: British Journal of Dermatology (2011)

Background Obesity in early childhood is associated with increased risk for and severity of atopic dermatitis (AD). Objective To determine whether obesity in adulthood is associated with risk of AD. Methods This was a retrospective case–control study of 2090 adults using questionnaire, height and weight, and skin‐prick testing between January 1994 and December 2003. Results Obesity in adults was associated with increased AD [multinomial logistic regression: adjusted odds ratio (aOR) 1·43, 95% confidence interval (CI) 1·08–1·89; P =0·01], but not nonatopic dermatitis (aOR 0·59, 95% CI 0·21–1·68; P =0·32). Obesity was also associated with increased atopic asthma (aOR 1·98, 95% CI 1·47–2·66, P <0·0001), but not associated with nonatopic asthma (P =0·20), atopic or nonatopic rhinoconjunctivitis (P =0·08 and 0·31, respectively), food allergies (P =0·67 and 0·35, respectively) or atopy (P =0·40). The association between obesity and AD remained significant even when controlling for history of asthma, rhinoconjunctivitis and food allergies (aOR 1·40, 95% CI 1·05–1·86; P =0·02) or in subset analyses of subjects with AD alone (aOR 1·96, 95% CI 1·02–3·75; P =0·04) and with comorbid asthma, rhinoconjunctivitis and/or food allergies (aOR 1·40, 95% CI 1·03–1·91; P =0·03). Conclusion Obesity in adulthood is associated with AD. Further studies are warranted to determine if weight loss may prevent or mitigate AD in adults.
Instrumentation and practice standards for electrocardiographic monitoring in special care units. A report for health professionals by a Task Force of the Council on Clinical Cardiology, American Heart Association.
Authors: D M Mirvis, A S Berson, A L Goldberger, L S Green, J J Heger, T Hinohara, J Insel, M W Krucoff, A Moncrief, R H Selvester
Journal: Circulation (1989)

The proposed recommendations for continuous electrocardiographic monitoring systems represent goals for future development. Description of a technique in the report does not constitute an endorsement of its clinical use. Lead systems for ECG monitoring must adequately sense the cardiac electrical field and the leads should be standardized. Future monitors should be capable of simultaneously displaying and analyzing multiple leads. Recommendations for electrode placement and position of patient are made. Important parameters in each category of standards for instrumentation published in 1983 in the American National Standard for Cardiac Monitors, Heart Rate Meters, and Alarms are listed. Selected procedures proposed by the Association for the Advancement of Medical Instrumentation to inform users of minimally acceptable accuracy of computerized systems in a standardized manner are presented. Emphasis is placed on the importance of nursing and medical staff capabilities. Personnel qualifications and training as well as systems to assure and maintain quality of immediate ECG diagnosis are highlighted.
Educating Residents Why Less Is More With Telemetry
Authors: Mona Beier, Daniel J. Morgan, Mangla Gulati
Journal: JAMA Internal Medicine (2015)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Internal Medicine HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Internal Medicine journal