tbuckley/cabot-search huggingface dataset:
MORE ON PH
Authors: A. GORMAN HILLS
Journal: Annals of Internal Medicine (1967)

Letters and Comments1 January 1967MORE ON PHA. GORMAN HILLS, M.D., EDWARD L. REID, M.D.A. GORMAN HILLS, M.D., EDWARD L. REID, M.D.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-66-1-238 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail Excerpt[In the letter entitled "pH Defended" by Drs. Hills and Reid (Ann. Intern. Med. 65: 1150, 1966) an unfortunate typographical error obscured the meaning and one reference in their line of thought. This error was the omission of part of a sentence (as shown in boldface below). The sentences beginning on line 26, column 1, should have read:Sörensen (3) and Clark (4) then showed that it is variation of the logarithm of [H+], rather than of [H+] itself, that is most simply and generally related to acid-base equilibria and to related kinetic aspects of solution chemistry, a penetrating insight...References1. LENNONLEMANN EJJ: Defense of hydrogen ion concentration in chronic metabolic acidosis. A new evaluation of an old approach. Ann. Intern. Med. 65: 265, 1966. LinkGoogle Scholar2. HILLSREID AGEL: pH defended (letters and comments). Ibid., p. 1150. Google Scholar3. LENNONLEMANN EJJ: Is pH defensible? (letters and comments). Ibid., p. 1151. Google Scholar4. HUCKABEE WE: Henderson vs. Hasslebalch. Clin. Res. 9: 116, 1961. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: A. GORMAN HILLS, M.D.; EDWARD L. REID, M.D.Affiliations: University of Miami School of Medicine Miami, Fla. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byRIl centenario del pH (1909-2009) - Parte seconda. Ma era proprio necessario sostituire l'equazione di Henderson con quella di Henderson-Hasselbalch?In defence of pHpH and the Henderson-Hasselbalch equation 1 January 1967Volume 66, Issue 1Page: 238-239 ePublished: 1 December 2008 Issue Published: 1 January 1967 PDF downloadLoading ...
Alcohol and Smoking as Risk Factors in an Epidemiology Study of Patients With Chronic Pancreatitis
Authors: Gregory A. Coté, Dhiraj Yadav, Adam Slivka, Robert H. Hawes, Michelle A. Anderson, Frank R. Burton, Randall E. Brand, Peter A. Banks, Michele D. Lewis, James A. Disario, Timothy B. Gardner, Andres Gelrud, Stephen T. Amann, John Baillie, Mary E. Money, Michael O'Connell, David C. Whitcomb, Stuart Sherman
Journal: Clinical Gastroenterology and Hepatology (2010)
Studies of immune functions of patients with systemic lupus erythematosus: antibodies to desialized, rather than intact, T cells preferentially bind to and eliminate suppressor effector T cells.
Authors: M Honda, T Sakane, A D Steinberg, H Kotani, T Tsunematsu, K Moriyama, M Fukase
Journal: Journal of Clinical Investigation (1982)

Patients with systemic lupus erythematosus (SLE) were found to have in their plasma antibodies specific for desialized T cells. Adsorption studies with intact or desialized T cells indicated that SLE anti-T cell antibodies consisted of two populations with different target cell specificities, one capable of recognizing unique determinants on desialized T cells and another able to bind to both intact and desialized T cells. Normal T cells did not remove the antibodies specific for desialized T cells. moreover, the antibodies to desialized T cells were not removed by adsorption with either desialized non-T cells or desialized erythrocytes. Thus, the antibodies to desialized T cells recognize a determinant that is unique to a T cell subset and also includes a sugar. Inhibition studies with various sugars indicated that lactose was the most potent inhibitor of antibody binding. The anti-desialized T cell antibody appears to recognize a T cell determinant which includes lactose, probably in the form of a beta-galactosyl residue, but which also includes additional T cell determinants. The antibodies to desialized T cells were found to bind preferentially to concanavalin A-induced autorosetting T cells, which had been already demonstrated to contain suppressor effector cells. Indeed, such antibodies were effective in eliminating suppressor effector function without interfering with T cells necessary for such activation (such as precursor or inducer cells). Finally, studies of patients with SLE yielded a highly significant correlation (r = 0.92) between impaired suppressor effector function of their cells and the presence of antibodies to desialized T cells in their plasma.
Walking, Jumping, Collaboration, and Competition Characterize Race to Cystic Fibrosis Gene
Authors: Beverly Merz
Journal: JAMA (1989)

THE INDENTIFICATION of the cystic fibrosis (CF) gene earlier this month culminated one of the most concerted and competitive efforts in the history of medical genetics. Cystic fibrosis' high incidence (one in 2000 births in the United States), severity, and resistance to prenatal diagnosis has made its gene an especially attractive prey for molecular biologists and geneticists. The race to find the gene began, for all practical purposes, in 1980 with the discovery that restriction fragment length polymorphisms (RFLPs), stretches of DNA that vary among people, could serve as diagnostic markers if they were close enough to a disease gene to be inherited with the gene most of the time. By analyzing the DNA from several members of an affected family, it was often possible to tell which RFLP haplotype signaled the disease in that family. Lap-Chee Tsui, PhD, became involved in the quest to find RFLPs associated with the
Triptolide sensitizes AML cells to TRAIL-induced apoptosis via decrease of XIAP and p53-mediated increase of DR5
Authors: Bing Z. Carter, Duncan H. Mak, Wendy D. Schober, Martin F. Dietrich, Clemencia Pinilla, Lyubomir T. Vassilev, John C. Reed, Michael Andreeff
Journal: Blood (2008)
Pathway Analysis of Breast Cancer Genome-Wide Association Study Highlights Three Pathways and One Canonical Signaling Cascade
Authors: Idan Menashe, Dennis Maeder, Montserrat Garcia-Closas, Jonine D. Figueroa, Samsiddhi Bhattacharjee, Melissa Rotunno, Peter Kraft, David J. Hunter, Stephen J. Chanock, Philip S. Rosenberg, Nilanjan Chatterjee
Journal: Cancer Research (2010)

Abstract Genome-wide association studies (GWAS) focus on relatively few highly significant loci, whereas less attention is given to other genotyped markers. Using pathway analysis to study existing GWAS data may shed light on relevant biological processes and illuminate new candidate genes. We applied a pathway-based approach to the breast cancer GWAS data of the National Cancer Institute (NCI) Cancer Genetic Markers of Susceptibility project that includes 1,145 cases and 1,142 controls. Pathways were retrieved from three databases: KEGG, BioCarta, and NCI Protein Interaction Database. Genes were represented by their most strongly associated SNP, and an enrichment score reflecting the overrepresentation of gene-based association signals in each pathway was calculated by using a weighted Kolmogorov-Smirnov procedure. Finally, hierarchical clustering was used to identify pathways with overlapping genes, and clusters with an excess of association signals were determined by the adaptive rank-truncated product (ARTP) method. A total of 421 pathways containing 3,962 genes was included in our study. Of these, three pathways (syndecan-1–mediated signaling, signaling of hepatocyte growth factor receptor, and growth hormone signaling) were highly enriched with association signals [PES &amp;lt; 0.001, false discovery rate (FDR) = 0.118]. Our clustering analysis revealed that pathways containing key components of the RAS/RAF/mitogen-activated protein kinase canonical signaling cascade were significantly more likely to have an excess of association signals than expected by chance (PARTP = 0.0051, FDR = 0.07). These results suggest that genetic alterations associated with these three pathways and one canonical signaling cascade may contribute to breast cancer susceptibility. Cancer Res; 70(11); 4453–9. ©2010 AACR.
The Mechanism of the Generation of the Third and Fourth Heart Sounds
Authors: LAMAR CREVASSE, MYRON W. WHEAT, JAMES R. WILSON, RICHARD F. LEEDS, W. JAPE TAYLOR
Journal: Circulation (1962)

A simple unitarian concept of the mechanism of third and fourth sounds is presented. This study demonstrates that the third sound occurs during early rapid diastolic ventricular filling at a time when atrial pressure exceeds ventricular pressure. It is recorded within the ventricle and on the ventricular wall. It coincides with ventricular muscle vibrations. The fourth sound is demonstrated to consist of two components, both occurring when atrial pressure exceeds ventricular. The first component coincides with the peak of atrial contraction, is recorded within the atria, and is inaudible. The second component, which is audible (25 to 70 cycles per second) and follows the first by 0.01 to 0.02 second, is recordable within the ventricle coinciding with the impact of blood from atrial systole against the ventricular wall. These observations demonstrate that the audible third and fourth heart sounds have a common origin in the ventricles and have the same temporal and hemodynamic relationships regardless of etiology.
Reciprocity and Qualifications as Viewed by the Illinois Board.
Authors: James A. Egan
Journal: JAMA (1906)

Springfield,Ill., July 24, 1906. <h3>To the Editor:</h3> —I can really see little occasion for replying to the very extraordinary comunication of Dr. B. D. Hanson, secretary of the Michigan State Board of Registration in Medicine, which was published inThe JournalJuly 21, under the above caption. As my silence might be misconstrued, however,—not by Dr. Harison, but by other readers ofThe Journal—I take occasion to comment on his various remarks. Dr. Harison exhibits unwarranted temper and marked discourtesy in his communication. It might be well if, before undertaking further correspondence concerning a sister medical examining body, if Dr. Harison would cultivate a "judicial temperament" and realize that he "represents a state rather than a base-ball organization." It must be apparent to every reader ofThe Journalthat Dr. B. D. Harison, secretary of the Michigan State Board of Registration in Medicine, concerns himself unnecessarily with the
Acute kidney injury and acute-on-chronic liver failure classifications in prognosis assessment of patients with acute decompensation of cirrhosis
Authors: Paolo Angeli, Ezequiel Rodríguez, Salvatore Piano, Xavier Ariza, Filippo Morando, Elsa Solà, Antonietta Romano, Elisabet García, Marco Pavesi, Alessandro Risso, Alexander Gerbes, Chris Willars, Mauro Bernardi, Vicente Arroyo, Pere Ginès
Journal: Gut (2014)

<h3>Abstract</h3> Bioinformatic pipelines optimised for the processing and assessment of metagenomic ancient DNA (aDNA) are needed for studies that do not make use of high yielding DNA capture techniques. These bioinformatic pipelines are traditionally optimised for broad aDNA purposes, are contingent on selection biases and are associated with high costs. Here we present a bioinformatic pipeline optimised for the identification and assessment of ancient metagenomic DNA without the use of expensive DNA capture techniques. Our pipeline actively conserves aDNA reads, allowing the application of a bioinformatic approach by identifying the shortest reads possible for analysis (22-28bp). The time required for processing is drastically reduced through the use of a 10% segmented non-redundant sequence file (229 hours to 53). Processing speed is improved through the optimisation of BLAST parameters (53 hours to 48). Additionally, the use of multi-alignment authentication in the identification of taxa increases overall confidence of metagenomic results. DNA yields are further increased through the use of an optimal MAPQ setting (MAPQ 25) and the optimisation of the duplicate removal process using multiple sequence identifiers (a 4.35-6.88% better retention). Moreover, characteristic aDNA damage patterns are used to bioinformatically assess ancient vs. modern DNA origin throughout pipeline development. Of additional value, this pipeline uses open-source technologies, which increases its accessibility to the scientific community.
A prospective randomised controlled clinical trial comparing somatostatin and vasopressin in controlling acute variceal haemorrhage.
Authors: S A Jenkins, J N Baxter, W Corbett, P Devitt, J Ware, R Shields
Journal: BMJ (1985)

Twenty two patients were entered into a randomised controlled clinical trial comparing the efficacy of somatostatin and vasopressin in controlling acute variceal haemorrhage. Somatostatin was significantly more successful in controlling acute variceal haemorrhage than vasopressin (p = 0.003). Furthermore, no complications were observed during treatment with somatostatin.
Another Clean Medical Journal
Authors: William H. Weir
Journal: JAMA (1910)

<h3>To the Editor:—</h3> An editorial inThe Journal, Aug. 20, 1910, p. 697, discusses the action of the<i>Gulf States Journal of Medicine and Surgery</i>in eliminating from its pages advertisements of such medicinal preparations as do not comply with the requirements of the Council on Pharmacy and Chemistry of the American Medical Association. May I call your attention to the fact that the<i>Cleveland Medical Journal</i>in November, 1909, announced a similar program and since then this rule has been observed in accepting new advertisements? Existing contracts, of course, had to be observed, and although practically all of the objectionable advertisements appeared for the last time in the issue of December, 1909, it was not until August, 1910, that the last one had disappeared. Publicity of such facts as the above should certainly help in inducing other independent journals to adopt a similar censorship.
Normal Oxidative Phosphorylation in Mitochondria from the Failing Heart
Authors: BURTON E. SOBEL, JAMES F. SPANN, PETER E. POOL, EDMUND H. SONNENBLICK, EUGENE BRAUNWALD
Journal: Circulation Research (1967)

Oxidative phosphorylation was measured polarographically in mitochondria isolated from normal ventricles and from the ventricles of guinea pigs and cats with experimental heart failure produced by constriction of the aorta or pulmonary artery. The presence of heart failure was proved by the study of myocardial mechanics in vitro, by cardiac catheterization, and by postmortem examination. Mitochondria from failing ventricles had normal oxidative phosphorylation, and P-O ratios, respiratory control, oxygen consumption and ATPase activity did not differ from those of mitochondria from normal hearts. Results were the same whether incubations were performed at 25° or 37°C and whether glutamate or pyruvate and malate were used as the substrate. Mitochondria showed functional deterioration, probably due to fatty acid accumulation, when incubated for more than 10 min at 37°C or when isolated from hearts made hypoxic in vivo for as little as 3 min. The results of this study suggest that decreased myocardial contractility in experimental heart failure is not due to an intrinsic defect in mitochondrial function.
Whose View of Life? Embryos, Cloning, and Stem Cells
Authors: A. W. Siegel
Journal: JAMA (2004)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
A Study of the Spatial Vectorcardiogram in Normal Subjects over the Age of Forty Years
Authors: J. A. ABILDSKOV
Journal: Circulation (1955)

The spatial vectorcardiograms of 114 normal subjects over the age of 40 years have been studied. Differences in the form, orientation and magnitude of the QRS loops of these records and those of younger normal subjects recorded with the same techniques were found. The study represents a further step in defining the normal spatial vectorcardiograms.
Differential expression of apolipoprotein E messenger RNA within the rat liver lobule determined byin situ hybridization
Authors: Mara Massimi, Steven R. Lear, David L. Williams, Albert L. Jones, Sandra K. Erickson
Journal: Hepatology (1999)

Apolipoprotein (Apo) E plays a key role in the metabolism of lipoproteins. It also modulates immunoregulation, cell growth and differentiation and the response to nerve injury. The liver is a major site of ApoE synthesis. Most of the circulating ApoE is thought to be of hepatic origin with most synthesized in hepatocytes. We showed that total liver ApoE messenger RNA (mRNA) levels were greater in normal adult female rats than in male and that gender-specific patterns of liver ApoE mRNA expression were present by in situ hybridization. In the male liver, the signal was strongest in the portal area, decreasing toward the central vein with the weakest signal in pericentral hepatocytes, resulting in a hepatic lobular gradient of expression. In female liver, a strong periportal signal also was observed that decreased in Zone 2, similar to that in males, but which then increased in pericentral hepatocytes resulting in a bowl-like distribution in marked contrast with that of the male. The results suggest that ApoE mRNA level is regulated differentially in hepatocytes within the liver plate and that the regulation is gender-dependent. Further, the results suggest that in males, hepatocytes in the portal area are the major contributors of ApoE to the plasma and/or sinusoidal pool, whereas in females, both portal and central area hepatocytes play an equal role.
How valuable is feedback of information on hospital referral patterns?
Authors: P de Marco, C Dain, T Lockwood, M Roland
Journal: BMJ (1993)

OBJECTIVES--To determine general practitioners9 responses to and explanations for variation in rates of referral to hospital and how feedback of data on rates of referral could be used to facilitate practices in auditing their own referral behaviour. DESIGN--Visits by audit facilitators to general practices after feedback of details of rates of referral to hospital derived from annual reports in general practice. SETTING--92 general practices in East Anglia. RESULTS--General practitioners judged that access to specialist care, the individual skill of general practitioners, patient demand, and fear of litigation were major determinants of referral behaviour. Because there was widespread scepticism about the accuracy of the data on which the feedback was based and because there is no clear relation between rates of referral and quality of care, it was extremely difficult to encourage doctors to use the feedback as a basis for auditing their own hospital referrals. CONCLUSION--If general practitioners are to contribute meaningfully to monitoring future changes in referral patterns it will be essential to develop reliable information systems in which doctors have confidence. Furthermore, audits need to be based on analysis of clinical cases rather than on rates of referral.
Advances in Neurology, vol 13: Current Reviews
Authors: Frank R. Freemon
Journal: JAMA (1976)

In this book are reviewed selected research areas that border basic and clinical neurology. Of special interest is the chapter by Walker and Weiss, predicting that the next decade will see advances in the chemotherapy of brain malignancies to rival recent improvements in the treatment of leukemia. The authors emphasize that clinical studies must be based on animal experimentation and basic pharmacological principles. A review of nutritional deprivation shows that in animals, the earlier the deprivation, the more permanent the behavioral effects. Many developing countries are crippled by a vicious circle of poverty, producing poor nutrition and incomplete mental development, which intensifies poverty, worsening the nutritional deprivation, and so on. An exhaustive review of the effects of synaptically active agents on seizure frequency plods through voluminous animal studies and uncontrolled clinical observations. Great variation, from model to model in experiments, and from case to case clinically obscures an overall tendency
Experience With Pregnant Problem Drinkers-Reply
Authors: Henry L. Rosett
Journal: JAMA (1983)

In Reply.—  We appreciate Dr Singh's favorable comments on our ten-question drinking history and treatment plan. A comparison of several forms of therapy for heavy drinking during pregnancy is an important subject for investigation. However, the goal of our research was to study the relationship between patterns of alcohol consumption and fetal development. We have reported demographic and behavioral maternal characteristics of 1,711 women who registered for prenatal care at Boston City Hospital between 1974 and 19791and evaluations of their newborns' conditions.2Sustained heavy drinking was associated with intrauterine growth retardation and congenital anomalies; reduction of heavy drinking benefited offspring.  The three phases of heavy drinking were described to help plan successful treatment strategies. When therapy was adapted to the needs of individual patients, the majority of women in each phase attained sobriety. Social characteristics and drinking patterns did not predict the effectiveness of therapy.  Since this
Gait Speed as an Incremental Predictor of Mortality and Major Morbidity in Elderly Patients Undergoing Cardiac Surgery
Authors: Jonathan Afilalo, Mark J. Eisenberg, Jean-François Morin, Howard Bergman, Johanne Monette, Nicolas Noiseux, Louis P. Perrault, Karen P. Alexander, Yves Langlois, Nandini Dendukuri, Patrick Chamoun, Georges Kasparian, Sophie Robichaud, S. Michael Gharacholou, Jean-François Boivin
Journal: Journal of the American College of Cardiology (2010)