tbuckley/cabot-search huggingface dataset:
Psychodynamic Understanding in Community Psychiatry
Authors: Jill Savege
Journal: Psychotherapy and Psychosomatics (1975)

Research Articles| February 12 2010 Psychodynamic Understanding in Community Psychiatry Subject Area: Psychiatry and Psychology Jill Savege Jill Savege Tavistock Clinic, Adolescent Department, London Search for other works by this author on: This Site PubMed Google Scholar Psychother Psychosom (1975) 25 (1-6): 272–278. https://doi.org/10.1159/000286880 Article history Published Online: February 12 2010 Content Tools Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Facebook Twitter LinkedIn Email Tools Icon Tools Get Permissions Cite Icon Cite Search Site Citation Jill Savege; Psychodynamic Understanding in Community Psychiatry. Psychother Psychosom 31 December 1975; 25 (1-6): 272–278. https://doi.org/10.1159/000286880 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAll JournalsPsychotherapy and Psychosomatics Search Advanced Search This content is only available via PDF. 1975Copyright / Drug Dosage / DisclaimerCopyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher.Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. Article PDF first page preview Close Modal You do not currently have access to this content.
Drug company raises US price of AIDS drug five-fold
Authors: Fred Charatan
Journal: BMJ (2004)

A decision made earlier this year by Abbott Laboratories to raise the U S price of itsprotease-inhibiting drug Norvir from about $1,500 (£843;€1,240) to $7,800 (£4,380;€6450) annually, which provoked an outcry among AIDS sufferers and organisations, has come underthe spotlight in a Federal public hearing.

The price of Norvir in other countries is much lower, because of government pricing restrictions. In Belgium, for example, is costs less than $720 (£440; €645) annually. Norvir is an adjunct of “drug cocktails” taken by many AIDS patients, to enhance the effectiveness of nearly all other protease inhibitors they may be taking.

Abbott justifies its …
An open pilot study of ambulatory photodynamic therapy using a wearable low-irradiance organic light-emitting diode light source in the treatment of nonmelanoma skin cancer
Authors: S.K. Attili, A. Lesar, A. McNeill, M. Camacho-Lopez, H. Moseley, S. Ibbotson, I.D.W. Samuel, J. Ferguson
Journal: British Journal of Dermatology (2009)

Photodynamic therapy (PDT) is a popular treatment for nonmelanoma skin cancer with clearance rates of between 70% and 100%. Although reported to have a superior cosmetic outcome, the inconvenience of hospital visits and discomfort during therapy are considered drawbacks.To present an open pilot study of a low-irradiance, potentially disposable, lightweight, organic light-emitting diode (OLED), which is an area-emitting light source (2 cm diameter), suitable for ambulatory PDT.Twelve patients with Bowen's disease (eight) and superficial basal cell carcinoma (four) < 2 cm in diameter were recruited into the study following histological confirmation of the diagnosis. Two treatments (45-60 J cm(-2) red light, 550-750 nm, peak 620 nm, irradiance 5 mW cm(-2)) were administered 1 month apart following application of aminolaevulinic acid for 4 h.At the 12-month follow-up, seven of the 12 patients remained clear, with four of the nonresponders demonstrating peripheral margin failure. Patients were scored for pain during and immediately after treatment using the numerical rating scale (NRS; 1-10). All 12 subjects scored pain as < 2 using the NRS (median score 1). In contrast, a similar cohort of 50 consecutive patients from our routine PDT clinic (Aktilite inorganic LED source; 75 J cm(-2), irradiance 80 mW cm(-2)) scored a median of 6 on the NRS.Pain and inconvenience are practical barriers to the use of conventional PDT. This pilot study suggests that OLED-PDT is less painful than conventional PDT with the added advantage of being lightweight, and therefore has the potential for more convenient 'home PDT'. These results need to be validated in larger studies.
BMA claims GMC guidance on conscience goes too far
Authors: Clare Dyer
Journal: BMJ (2007)

The BMA has clashed with the UK General Medical Council about draft guidance from the GMC for doctors who object to providing certain medical services on the ground that they conflict with their personal beliefs.

In its response to the draft of Personal Beliefs and Medical Practice the BMA argues that the guidance goes beyond doctors' widely accepted right to opt out of certain procedures that involve matters of life and death, such as abortion, contraceptive services, and the withdrawal of life prolonging treatment. The association claims it could confuse patients and give doctors a licence to …
The Genetic Defect in Galactosemia
Authors: T. A. Tedesco, J. W. Wu, F. S. Boches, W. J. Mellman
Journal: New England Journal of Medicine (1975)

GALACTOSE-1-PHOSPHATE uridylytransferase (E.C. 2.7.7.12 — subsequently referred to as "transferase") is the enzyme whose function is markedly, if not totally, deficient in the commonly recognized form of galactosemia — an inborn error of metabolism that was described as a clinical entity in 1908 and defined as resulting from a specific enzyme defect in 1956.1 Of all the enzymes involved in human genetic disease, this one has been particularly responsive to the combined attacks of biochemistry and genetics. Enough has been learned about this enzyme to enable a description of its mechanism of action in molecular terms, as well as a look at . . .
Diagnostic Challenges of Hepatitis C
Authors: Monica A. Konerman, Anna S. Lok
Journal: JAMA (2014)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
DELETION ON THE X CHROMOSOME DETECTED BY DIRECT DNA ANALYSIS IN ONE OF TWO UNRELATED BOYS WITH GLYCEROL KINASE DEFICIENCY, ADRENAL HYPOPLASIA, AND DUCHENNE MUSCULAR DYSTROPHY
Authors: D.B. Dunger, M. Pembrey, P. Pearson, A. Whitfield, K.E. Davies, B. Lake, D. Williams, M.J.D. Dillon
Journal: The Lancet (1986)
HLA DR alloantigens in different subsets of patients with Sjogren's syndrome and in family members.
Authors: D L Mann, H M Moutsopoulos
Journal: Annals of the Rheumatic Diseases (1983)

Patients with Sjögren9s syndrome alone (Ss), Sjögren9s syndrome with rheumatoid arthritis (Ss-RA), and Sjögren9s syndrome with Raynaud9s phenomenon (Ss-RP) were typed for the HLA DR and MT antigens. Ss-RA patients had higher frequencies of HLA DR4 than did Ss patients. HLA-DR4 was also increased in frequency in patients with Ss-RP. This group of patients also showed increases in frequencies of HLA DR3. MT2 frequencies were elevated in all 3 patient groups, while MT1 was only increased in Ss. Three families with multiple individuals with Sjogren9s syndrome were typed for HLA antigens. The affected individuals inherited unique combinations of haplotypes, suggesting the possibility of haplotype interaction in predisposition to disease.
Screening for Depression in Clinical Practice: An Evidence-Based Guide
Authors: Elaine W. Cotlove
Journal: JAMA (2010)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Deep Sedation with Propofol for Upper Gastrointestinal Endoscopy in Children, Administered by Specially Trained Pediatricians: a Prospective Case Series with Emphasis on Side Effects
Authors: E. Barbi, P. Petaros, L. Badina, T. Pahor, I. Giuseppin, E. Biasotto, S. Martelossi, G. Di Leo, A. Sarti, A. Ventura
Journal: Endoscopy (2006)

Background and Study Aims: The need to administer procedural sedation to children has increased in recent years, as has experience in this field among nonanesthesiologists. Using propofol makes it easier to achieve sufficiently deep sedation. There is a considerable literature on the administration of propofol by nonanesthesiologists for gastroscopy in adults, but very few data are available on this issue in children. The aim of the present study was to assess the safety and efficacy of procedural sedation with propofol for gastroscopy in a pediatric ward with trained personnel and monitoring facilities. Patients and Methods: A training protocol was developed to educate nurses and residents. Children requiring gastroscopy were included in the study prospectively and underwent procedural sedation with propofol administered by nonanesthesiologists. Results: A total of 811 upper gastrointestinal endoscopies were carried out with procedural sedation. Sedation was achieved in all procedures, and all but three (0.4 %) were conducted successfully. None of the patients required intubation. Stridor with signs of upper airway obstruction occurred in 14 of the 811 procedures (1.7 %). Laryngoscopy was required to manage difficulties in introducing the gastroscope in 16 of the 811 procedures (2.0 %). Major desaturation requiring a short course of ventilation occurred in six procedures (0.7 %), and transient desaturation that resolved spontaneously occurred in 97 of the procedures (12 %). Conclusions: Administration of propofol by nonanesthesiologists for gastroscopy examinations in children was successful in this study, but was associated with a small risk of potentially severe complications. Although the residents were generally able to administer procedural sedation alone, constant and immediate availability of anesthesiological support continues to be mandatory.
Results of photopatch testing in Rotterdam during a 10-year period
Authors: R.S.L.A. Bakkum, F. Heule
Journal: British Journal of Dermatology (2002)

Photoallergic contact dermatitis is of importance in a proportion of photodermatoses and can be evaluated through photopatch testing.To conduct a retrospective evaluation of photopatch tests performed in patients with suspected photodermatoses at the clinic at the University Hospital Rotterdam during a 10-year period.During the first 5(1/2) years 44 patients were tested with a standard set of 14 allergens, and during the next 4(1/2) years 55 patients were tested with a standard set of 23 allergens.Photocontact reactions were found in 9% and 27% of patients in the two periods, respectively. In the second period, positive reactions were mostly produced by sunscreens. The difference in the percentage of positive photopatch tests was probably caused by the difference in composition of the standard set of allergens (more sunscreens in the second period), this being the only alteration in the test procedure.The standard set of photoallergens has to be updated periodically. Standardization of the test procedure is needed to compare the test results of different institutions.
The highly lipophilic DNA topoisomerase I inhibitor DB-67 displays elevated lactone levels in human blood and potent anticancer activity
Authors: D. Bom, D.P. Curran, J. Zhang, S.G. Zimmer, R. Bevins, S. Kruszewski, J.N. Howe, A. Bingcang, L.J. Latus, T.G. Burke
Journal: Journal of Controlled Release (2001)
Photoallergic Contact Dermatitis
Authors: Stephan Epstein
Journal: JAMA (1965)

PHOTOALLERGIC contact dermatitis resulting from use of soap occurs rarely; however, several years ago in England there was an "epidemic" of photoallergic contact dermatitis caused by a soap which contained the potent antiseptic tetrachlorsalicylanilide (TCSA).<sup>1-4</sup>This agent proved to be an equally potent photosensitizer. The literature<sup>5-8</sup>contains only a few reports of cases of photoallergic dermatitis from this chemical in the United States. The sporadic cases which do occur are difficult to diagnose and very often are not recognized, thus prolonging the patient's misery. The following cases are reported to emphasize the importance of recognizing photosensitivity caused by a soap (in these two patients, Lifebuoy) containing an antiseptic related to TCSA, namely, tribromsalan (tribromosalicylanilide, TBS). <h3>Report of Cases</h3><h3>Case 1.—</h3> A 38-year-old white man, a traveling sales representative, consulted us in January 1965 because of an acute dermatitis of the face and neck, which was spreading to the
The Thumb in Trisomy-18
Authors: Charles F. Johnson
Journal: JAMA (1971)

To the Editor.—  The letter toThe Journal(213:1192, 1970) regarding an abnormal hand which simulated trisomy-18 was interesting. The authors, while commenting on the  of the index and fifth fingers which caused them to deviate medially and overlap the ring and the middle fingers, as in trisomy-18, failed to emphasize that their patient's thumb appeared normal.  The thumb in trisomy-18 is unusual (Figure).1It is high-set and short with an ulnar clinodactyly which may cause it to overlap the second digit. The hypoplasia of the thenar eminence is marked and has been shown to be due to aplasia of intrinsic thenar musculature.2  This high position of the thumb persists even when the overlapping finger anomalies disappear in time. Had the illustration of a trisomy-18 hand in the article exposed a more favorable view of the thumb, the similarity between the hands of the patient presented
Needle Biopsy Aspiration Smears
Authors: William H. Kern
Journal: JAMA (1973)

<h3>To the Editor.—</h3> Needle aspiration smears are an important diagnostic tool and should be more widely used provided that the cases are properly selected, the pertinent clinical data are submitted to the pathologist, and that the pathologist is experienced in the interpretation. The article by Kline and Neal (224:1143, 1973) reports a small series of cases, including four of carcinoma of the breast that compares with 315 recently reported by Hajdu and Melamed (<i>Am J Clin Pathol</i>59:350, 1973). The aspiration biopsy smears from solid tumors are tabulated jointly with aspiration smears of cyst fluids and is misleading. Invasion of a cyst wall by carcinoma is rare and in our own case material, over a three-year period the follow-up studies on 467 patients from whom breast fluid had been aspirated were negative although five cases had been cytologically atypical. To have one of four breast carcinomas diagnosed by examination of
Detection of Coronary Artery Stenosis With Power Doppler Imaging
Authors: Flordeliza S. Villanueva, Edward W. Gertz, Melissa Csikari, Gregory Pulido, David Fisher, Jiri Sklenar
Journal: Circulation (2001)

Power Doppler is a new imaging method for detecting microbubbles during myocardial contrast echocardiography (MCE) based on the registration of variance resulting from ultrasound-induced nonlinear bubble behavior. We tested the hypothesis that power Doppler imaging can be used to quantify coronary stenoses.Three left anterior descending (LAD) coronary stenoses of varying severity were created in each of 9 open-chest dogs. MCE was performed by continuous intravenous infusion of a nitrogen-filled bilayer shell microbubble, PB127, during triggered power Doppler imaging at incremental pulsing intervals. MCE and radiolabeled microsphere measurements were made at baseline and during each stenosis, with and without adenosine stress. Videointensities in the LAD and left circumflex (LCx) beds were plotted against pulsing interval and fit to a previously described exponential function modeling microbubble destruction and replenishment, which was used to derive parameters of bubble velocity (beta) and peak plateau videointensity (A). Contrast defects matching the location of radiolabeled microsphere hypoperfusion were clearly seen, without need for image processing. The product of beta and A was linearly related to LAD/LCx flow (r=0.90, P<0.0001) and inversely related to stenosis gradient (r=-0.70, P<0.0001). Endocardial/epicardial flow ratios were visualized and quantifiable.As with B-mode harmonics, a model of microbubble destruction/replenishment can be applied to power Doppler data as a means to detect a broad range of stenoses. Image clarity and the lack of attenuation or requirement for background subtraction are additional advantages of this imaging approach. Power Doppler MCE imaging holds promise for the detection of coronary artery disease.
Randomized comparison of anatomic and electrogram mapping approaches to ablation of the slow pathway of atrioventricular node reentrant tachycardia
Authors: Steven J. Kalbfleisch, S.Adam Strickberger, Brian Williamson, Vicken R. Vorperian, Ching Man, John D. Hummel, Jonathan J. Langberg, Fred Morady
Journal: Journal of the American College of Cardiology (1994)
Induction of osteoclastogenesis and bone loss by human autoantibodies against citrullinated vimentin
Authors: Ulrike Harre, Dan Georgess, Holger Bang, Aline Bozec, Roland Axmann, Elena Ossipova, Per-Johan Jakobsson, Wolfgang Baum, Falk Nimmerjahn, Eszter Szarka, Gabriella Sarmay, Grit Krumbholz, Elena Neumann, Rene Toes, Hans-Ulrich Scherer, Anca Irinel Catrina, Lars Klareskog, Pierre Jurdic, Georg Schett
Journal: Journal of Clinical Investigation (2012)

Autoimmunity is complicated by bone loss. In human rheumatoid arthritis (RA), the most severe inflammatory joint disease, autoantibodies against citrullinated proteins are among the strongest risk factors for bone destruction. We therefore hypothesized that these autoantibodies directly influence bone metabolism. Here, we found a strong and specific association between autoantibodies against citrullinated proteins and serum markers for osteoclast-mediated bone resorption in RA patients. Moreover, human osteoclasts expressed enzymes eliciting protein citrullination, and specific N-terminal citrullination of vimentin was induced during osteoclast differentiation. Affinity-purified human autoantibodies against mutated citrullinated vimentin (MCV) not only bound to osteoclast surfaces, but also led to robust induction of osteoclastogenesis and bone-resorptive activity. Adoptive transfer of purified human MCV autoantibodies into mice induced osteopenia and increased osteoclastogenesis. This effect was based on the inducible release of TNF-α from osteoclast precursors and the subsequent increase of osteoclast precursor cell numbers with enhanced expression of activation and growth factor receptors. Our data thus suggest that autoantibody formation in response to citrullinated vimentin directly induces bone loss, providing a link between the adaptive immune system and bone.
Myocardial infarction redefined—a consensus document of The Joint European Society of Cardiology/American College of Cardiology committee for the redefinition of myocardial infarction
Authors: Elliott Antman, Jean-Pierre Bassand, Werner Klein, Magnus Ohman, Jose Luis Lopez Sendon, Lars Rydén, Maarten Simoons, Michal Tendera
Journal: Journal of the American College of Cardiology (2000)
The Expanding World of Tissue Engineering: The Building Blocks and New Applications of Tissue Engineered Constructs
Authors: Pinar Zorlutuna, Nihal Engin Vrana, Ali Khademhosseini
Journal: IEEE Reviews in Biomedical Engineering (2013)

The field of tissue engineering has been growing in the recent years as more products have made it to the market and as new uses for the engineered tissues have emerged, motivating many researchers to engage in this multidisciplinary field of research. Engineered tissues are now not only considered as end products for regenerative medicine, but also have emerged as enabling technologies for other fields of research ranging from drug discovery to biorobotics. This widespread use necessitates a variety of methodologies for production of tissue engineered constructs. In this review, these methods together with their non-clinical applications will be described. First, we will focus on novel materials used in tissue engineering scaffolds; such as recombinant proteins and synthetic, self assembling polypeptides. The recent advances in the modular tissue engineering area will be discussed. Then scaffold-free production methods, based on either cell sheets or cell aggregates will be described. Cell sources used in tissue engineering and new methods that provide improved control over cell behavior such as pathway engineering and biomimetic microenvironments for directing cell differentiation will be discussed. Finally, we will summarize the emerging uses of engineered constructs such as model tissues for drug discovery, cancer research and biorobotics applications.