tbuckley/cabot-search huggingface dataset:
Lentigo and Electrocardiographic Changes
Authors: Norman L. Matthews
Journal: New England Journal of Medicine (1968)

MORE than a year ago Walther, Polansky and Grots† presented an original description of a family whose members have both generalized lentigo and electrocardiographic abnormalities. I have had under observation a child (M.H.) with such an association and was prompted by the article of Walther et al. to study two other members of the family who were known to have generalized lentigo. The purpose of this communication is to report the electrocardiographic findings of the three family members, to add to the report of Walther and his co-workers and perhaps to confirm the association of lentigo and electrocardiographic changes as . . .
Remarks on Sir James Graham's Amended Medical and Surgical Bill
Authors: G. W. Hardy
Journal: BMJ (1845)

is supposed that, according to this amended bill, all the present members of the Royal College of Surgeons, who are not fellows also, could only be registered as licentiates in medicine and surgery.There are some, however, wbo think differently, and as the profession generaily are deeply interested in the satisfactory ad- justment of the measure, it is highly desirable that all misunderstanding on this point should be speedily removed.In no other way, perhaps, can this be more easily accomplislhed than by direct inquiry from Sir James Graham himself, in his place in Parliament; and it is hoped that some member of House will put the question to him.In the mean time, it may not be altogether useless to examine the various clauses which bear upon it.According to the 13th clause, it appears that in future, medical and surgical practitioners are to be registered as physicians, surgeons, or licentiates in medicine and surgery.In the 14th, 15th, and 16th clauses, the qualifica, tions which will entitle any one to registration under each of these three clases, are clearly explained.But in each of them there is an exception made in favour of certain parties, " for whose registration," it is said, 4' special provision is hereinafter made."This special provision is nowhere to be foiund, except in the 32nd clause, which enacts " that it shall *be lawful for the Council, on the application of any person legally practising, or entitled to practise, at the end of this Session of Parliament, as a physician, or
Amblyopia with Haemorrhages Due to Tobacco and (?) Lead Poisoning
Authors: M. Gilchrist
Journal: BMJ (1926)

THE followinig case presents man-y poinits of both medico- legal anid cliniical interest.A plumber, aged 43, was admitted to the Victoria Inifirmary, Glasgow, as a case of intracraniial pressure.He comrplained of dimness of vision of four to five mouiths' duratio-i.His family history was good.His health was quite good until five years ago.He was never off school nor off work till theni.Since then
Pacemaker Lead Vegetation Trapped in Patent Foramen Ovale
Authors: Yvan Le Dolley, Franck Thuny, Emilie Bastard, Alberto Riberi, Laurence Tafanelli, Sébastien Renard, Frédéric Franceschi, Sébastien Prévot, Jean-François Avierinos, Gilbert Habib, Jean-Claude Deharo
Journal: Circulation (2009)
Skipping Rope Fatalities.
Authors: Winfield S. Hall
Journal: JAMA (1905)

Chicago, May 23, 1905. <h3>To the Editor:</h3> —Your point against rope-jumping is well taken. During a period of four years as medical inspector and medical advisor in certain Philadelphia schools I took every opportunity to discourage rope-jumping, and particularly for all girls over 11 years of age. My objection was that that exercise tended to cause displacement of the uterus of adolescent girls. I would urge physicians to discourage rope-jumping.
Lack of apolipoprotein E dramatically reduces amyloid β-peptide deposition
Authors: Kelly R. Bales, Tatyana Verina, Richard C. Dodel, Yansheng Du, Larry Altstiel, Mark Bender, Paul Hyslop, Edward M. Johnstone, Sheila P. Little, David J. Cummins, Pedro Piccardo, Bernardino Ghetti, Steven M. Paul
Journal: Nature Genetics (1997)
The Role of Automated Speech Recognition in Endoscopic Data Collection
Authors: R. S. Johannes, D. L. Carr-Locke
Journal: Endoscopy (1992)

Speech recognition technology has developed substantially in the past half decade. Currently, large vocabulary, speaker independent, discrete recognizers are the state-of-the-art. This will change. Moderate sized, continuous recognition systems now exist in research settings. However, it is unlikely that such systems will be widely available until the mid to late 1990's. The accuracy rates of current speech recognition systems are high. Consequently, speech accuracy is not the current limiting aspect of using ASR. The limiting aspect of using ASR technology is the approach to integrating speech functionality into applications. One approach is to use ATNs as models of natural language to support both an input strategy and a text generation system. ATNs provide approaches to both syntactical correctness and semantic richness. This is an approach which plays to the strengths of the discrete nature of current speech technology and also provides a methodology for the capture and archiving of highly detailed information. The ATN approach avoids the natural language parsing problem created by a fully free form dictation interface. Evolving along with the underlying speech technology are standards in the definitions and criteria used in endoscopic practice. There are clear benefits from standards in this area. However, it is likely that this will also take several years and may never yield a universally accepted lexicon. Furthermore, there will be user interface barriers to surmount in any system attempting to use speech as an input modality. Because of the relatively large vocabularies used in medical discourse, the user interface will need to be carefully crafted.(ABSTRACT TRUNCATED AT 250 WORDS)
CAN OPSONIC ESTIMATIONS BE RELIED ON IN PRACTICE?
Authors: E. C. Hort
Journal: BMJ (1909)

Epithelial and pus cells ICultures on blood serum of creams and deposits showed the presence of a large Gram-positive, spore-bearing bacillus, pro- bably B. subtilis, only (not inoculated or investigated further).Specific examination after pasteurization-B.coli communis absent from ... ...
Durable molecular remissions with a single cycle of timed sequential consolidation chemotherapy in acute promyelocytic leukemia
Authors: Steven D. Gore, B. Douglas Smith, Ivana Gojo, Michael Grever, Scott H. Kaufmann, Louis Letendre, Debra G.B. Leonard, Guido Marcucci, Carole B. Miller, Lawrence Morris, Steven Piantadosi, Thomas Prior, Wendy Stock, Judith E. Karp
Journal: American Journal of Hematology (2005)

Abstract In a pilot study to reduce the duration of treatment and potential long‐term toxicities, 39 patients with acute promyelocytic leukemia in remission received a single cycle of intensive consolidation therapy, followed by intermittent ATRA maintenance. Consolidation therapy required prolonged hospitalization and was associated with a high incidence of mucositis (43% grade II or greater) and documented infection (45%). No deaths occurred during consolidation. Seven patients have relapsed; all other patients are in molecular remission (median follow‐up, 2.75 years). Kaplan–Meier estimate of 3 year disease‐free survival is 73% (95% confidence interval 55–91%). The relapse rate (0.06 relapses/patient‐year of follow‐up) is well within the range of larger published series that administer more prolonged consolidation. One patient has developed secondary myelodysplastic syndrome. These pilot data suggest that decreasing the total duration of consolidation chemotherapy did not compromise disease‐free survival for APL patients induced with ATRA/anthracycline and given intermittent ATRA maintenance. However, the toxicity of the consolidation module and the development of secondary myelodysplasia despite decreased total therapy emphasize the need to further improve and refine curative therapy for APL. Am. J. Hematol. 79:119–127, 2005. © 2005 Wiley‐Liss, Inc.
A review on the occasion of the retirement of Professor Philip Wood.
Authors: E G Bywaters
Journal: Annals of the Rheumatic Diseases (1990)

of the London Hospital has succeeded to this important post.It is thus an excellent time to review the ERU's swift rise to fame in the national and international rheumatism field and beyond, and its further potential for development in a rapidly changing world.Wood's citation from Heraclitus, that 'you never step twice into the same river', was a memorable reminder of today's problems, when the river flows faster than it has ever done before and when its flora and fauna are deteriorating even more rapidly owing to pollution in various forms.The original impetus for these now famous studies came from the request of the Miners' Welfare Commission in 1948 to the departments of rheumatism (Professor Kellgren) and occupational health (Professor R E Lane) of the University of Manchester to survey rheumatism in miners.Dr John Lawrence was appointed to do this.He had had an unusual background: qualifying in 1930 in Edinburgh, he spent the next 18 years in junior hospital posts and general practice with occasional periods in research, and with the encouragement of Professor Francis Fraser at the Postgraduate Medical School of London at Hammersmith in 1938 he conducted a trial of the effects of gold on rheumatoid arthritis controlled by placebo injec- tion, long before such precautions had become mandatory.From there he began research on the erythrocyte sedimentation rate, publishing a book on this subject, and thence to service in the Royal Air Force.He was led into the study of epidemiology through the National Coal Board in 1948.Rheumatic complaints were common (30%) in both miners and non-mining employees of the National Coal Board, but loss of work, due largely to back and knee trouble, was significantly greater in the miners, associated with heavy lifting and stooping in low coal seams.Professor Kellgren in 1954 with a grant from the Medical Research Council extended these surveys, and in 1956 the Arthritis and Rheumatism Council set up the Field Unit with Dr Lawrence as director.Thenceforth population studies were started in numerous other areas as well as family studies in Manchester, Taplow, and Hammersmith, twin studies, and occupational studies, all with the aid of serological and radiological investigation and in close col- laboration with other centres.The mobile equipment was supplied by the Wellcome Trust.These surveys made a wide impact when published because for the first time we were made aware of the considerable prevalence of rheuma- on July 18,
Influence of Height on Quantitative Sensory, Nerve-Conduction, and Clinical Indices of Diabetic Peripheral Neuropathy
Authors: Maria T Gadia, Norihiko Natori, Laura B Ramos, D Ram Ayyar, Jay S Skyler, Jay M Sosenko
Journal: Diabetes Care (1987)

We have examined associations between height and quantitative sensory, nerve-conduction, and clinical indices of diabetic peripheral neuropathy in adult diabetic patients. Vibratory sensitivity was strongly related to height when measurements were made with either the vibration sensitivity tester (P = .02) or the biothesiometer (P less than .01); however, there was no relation between thermal sensitivity (as measured with the thermal sensitivity tester) and height. The peroneal and posterior tibial motor nerve-conduction velocities were inversely related to height (P less than .05 for both). When age and diabetes duration were included as variables in multiple regression analyses, the associations with height became stronger. Clinical indices of peripheral neuropathy were also related to height in these analyses. Glycosylated hemoglobin was significantly related to thermal sensitivity and the peroneal and posterior tibial motor nerve-conduction velocities but not to vibratory sensitivity. These data indicate that height has a marked influence on quantitative sensory, nerve-conduction, and clinical indices of diabetic peripheral neuropathy.
Environmentalists seek to set research agenda on indoor air pollution
Authors: B. Roehr
Journal: BMJ (2011)

Nearly half the world’s people use open fires and traditional biomass cooking stoves that expose them to indoor air pollution and cause an estimated 1.9 million premature deaths a year. Women and children are particularly affected.

The Global Alliance for Clean Cookstoves seeks to reduce this exposure through a switch to cleaner, more efficient alternatives. It is promoting the ambitious goal of converting 100 million homes by the year 2020.

A three day meeting of health advocates and biomedical researchers has proved to be the catalyst for setting a research agenda on indoor air pollution in developing countries. The US National Institutes of Health organised the conference, held near Washington, DC, on 9-11 May.

Themes reported by the conference’s working groups included …
Michel M. Ter-Pogossian, PhD
Authors: Ronald G. Evens
Journal: JAMA (1996)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Identification of novel immune checkpoints as targets for cancer immunotherapy
Authors: Galit Rotman, Ofer Levy, Amir Toporik, Gady Cojocaru, Liat Dassa, Iris Hecht, Ilan Vaknin, Anat Oren, Zohar Tiran, Nora Tarcic, Sergey Nemzer, Tania Pergam, Amit Novik, Shirley Sameah-Greenwald, Joseph R Podojil, Stephen D Miller, Judith Leitner, Peter Steinberger, Eyal Neria, Zurit Levine
Journal: Journal for ImmunoTherapy of Cancer (2013)

Meeting abstracts Members of the B7/CD28 family of immune checkpoints, such as CTLA-4, PD1 and PDL-1, play critical roles in T cell regulation and have emerged as promising drug targets for cancer immunotherapy. Utilizing Compugen’s predictive discovery platform, we identified novel members of
Chemical stability of adapalene and tretinoin when combined with benzoyl peroxide in presence and in absence of visible light and ultraviolet radiation
Authors: None Martin, None Meunier, None Montels, None Watts
Journal: British Journal of Dermatology (1998)

Adapalene and tretinoin are molecules used in the topical treatment of acne vulgaris. Commercial formulations (adapalene 0.1% gel and tretinoin 0.025% gel) were mixed with equal volumes of commercially available benzoyl peroxide formulation (10% lotion) and subsequently exposed to light over 24 h. With and without exposition to light, adapalene exhibits a remarkable stability whereas tretinoin is very sensitive to light and oxidation. The combination of benzoyl peroxide and light results in more than 50% degradation of tretinoin in about 2 h and 95% in 24 h.
NHS reforms A conspiracy exists
Authors: J T Hart, P Draper
Journal: BMJ (1994)

EDITOR, — Chris Ham denies that government policies “are guided by a … hidden agenda which, through a series of incremental steps, will result in more private involvement in the financing and delivery of health services…. Politicians [are] not that clever [and] for any government to undermine the NHS, however surreptitiously, would be electoral suicide. In practice, health policy is more the result of cock up than conspiracy.”1

The Conservatives gained power in 1979 with a simple agenda: to remove, so far as possible, social decisions from the elected government so that they become byproducts of the pursuit of profit in deregulated markets. The contradiction inherent in running a popular socialised service as a competitive business is obvious. Even the stupidest politician knows that if you …
Meta-analysis in cancer epidemiology.
Authors: R D Morris
Journal: Environmental Health Perspectives (1994)

Meta-analysis has seen increasing use as a tool in epidemiology over the past five years. Although this method is relatively well accepted for use in clinical trials, its use has proved somewhat more controversial in epidemiology. If meta-analysis is viewed as an evolutionary improvement over the review article, it may become more widely acceptable. Meta-analysis should incorporate the concern for study quality and differences in study design seen in classic review articles with the concern for rigor, objectivity, and quantitative precision characteristic of meta-analysis. Available tools for consideration of differences among studies are described with several examples from the literature. The extent to which various methods are used in published meta-analyses is described. Methods for assessing publication bias, and tools for combining dose-response data, are discussed also. Evaluation of risk factors and protective factors for cancer must be based on the weight of the evidence. Tools such as meta-analysis are essential if we are to interpret the vast number of completed studies in cancer epidemiology.
Abstract 248: Vitamin D deficiency promotes hepatocellular carcinoma tumor growth in TGF-β impaired mice by Smad3 heterozygous deletion
Authors: Nina M. Muñoz, Lior H. Katz, Keigo Machida, Hidekazu Tsukamoto, Kirty Shetty, Aiwu R. He, Lynt B. Johnson, Asif Rashid, Sang Bae Kim, Ju-Seog Lee, Lopa Mishra
Journal: Cancer Research (2014)

Abstract Hepatocellular carcinoma (HCC) is the third most common cause of cancer-related deaths worldwide. Vitamin D (VD) has been implicated in the prevention of multiple cancers, some of which are characterized by inactivation of TGF-β signaling. Recently, inactivation of TGF-β signaling has been associated with development of HCC. We examined the potential role of VD in HCC chemoprevention in the context of TGF-β inactivation in a mouse model. Methods: Wild type, Sptbn1+/- and Smad3+/- male mice were treated with 50 mg/kg of the chemical carcinogen diethylnitrosamine (DEN) via i.p. injection at 14 days of age. At 8 months, the animals were changed from regular chow (2,200 IU/kg VD) to one of two diets: lower than normal VD (200 IU/kg) or high VD (10,000 IU/kg). At one year of age, the livers were harvested for tissue analysis. Several metrics were assessed including expression levels of 164 proteins from liver tumors by Reverse Phase Protein Array (RPPA). Results: Twenty three mice were treated with lower than normal dose VD while 26 received high dose VD. We did not find significant differences in blood calcium levels in animals on either diet. As expected, high VD intervention after 8 months of DEN injection did not affect the total number of tumors the mice developed; however, the lower than normal VD regimen promoted tumor growth in the context of Smad3 disruption (liver-to-body weight ratio 18.37% in Smad3+/- mice treated with low dose VD vs. 6.25% in Smad3+/- animals treated with high dose, p=0.028). Furthermore, RPPA data revealed that the lower than normal VD intake in DEN-treated Smad3 heterozygous null mice results in repression of tumor suppressing genes such as PDCD4 and concomitant up-regulation of tumor promoting genes like Stat5A, Bcl2-XL, PDGFRB and PEA15. Conclusions: Remarkably, lower than normal VD in the context of Smad3 disruption promotes tumor growth possibly through repression of tumor suppressing genes such as PDCD4 and up-regulation of oncogenes like Stat5A, Bcl2-XL, PDGFRB and PEA15. These results suggest that VD treatment strategies could potentially be significant for chemoprevention and treatment of HCC in the context of inactivation of TGF-β signaling in patient populations with underlying deficiency of VD. Citation Format: Nina M. Muñoz, Lior H. Katz, Keigo Machida, Hidekazu Tsukamoto, Kirty Shetty, Aiwu R. He, Lynt B. Johnson, Asif Rashid, Sang Bae Kim, Ju-Seog Lee, Lopa Mishra. Vitamin D deficiency promotes hepatocellular carcinoma tumor growth in TGF-β impaired mice by Smad3 heterozygous deletion. [abstract]. In: Proceedings of the 105th Annual Meeting of the American Association for Cancer Research; 2014 Apr 5-9; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2014;74(19 Suppl):Abstract nr 248. doi:10.1158/1538-7445.AM2014-248
Smoking Cessation and Cardiovascular Disease Risk Factors: Results from the Third National Health and Nutrition Examination Survey
Authors: Arvind Bakhru, Thomas P. Erlinger
Journal: PLoS Medicine (2005)

Cigarette smoking is a major risk factor for the development and progression of cardiovascular disease. While smoking is associated with increased levels of inflammatory markers and accelerated atherosclerosis, few studies have examined the impact of smoking cessation on levels of inflammatory markers. The degree and rate at which inflammation subsides after smoking cessation are uncertain. It also remains unclear as to whether traditional risk factors can adequately explain the observed decline in cardiovascular risk following smoking cessation.Using data from 15,489 individuals who participated in the Third National Health and Nutrition Examination Survey (NHANES III), we analyzed the association between smoking and smoking cessation on levels of inflammatory markers and traditional cardiovascular risk factors. In particular, we examined changes in C-reactive protein, white blood cell count, albumin, and fibrinogen. Inflammatory markers demonstrated a dose-dependent and temporal relationship to smoking and smoking cessation. Both inflammatory and traditional risk factors improved with decreased intensity of smoking. With increased time since smoking cessation, inflammatory markers resolved more slowly than traditional cardiovascular risk factors.Inflammatory markers may be more accurate indicators of atherosclerotic disease. Inflammatory markers returned to baseline levels 5 y after smoking cessation, consistent with the time frame associated with cardiovascular risk reduction observed in both the MONICA and Northwick Park Heart studies. Our results suggest that the inflammatory component of cardiovascular disease resulting from smoking is reversible with reduced tobacco exposure and smoking cessation.
EARLY CESSATION OF ADP RECEPTOR INHIBITORS AMONG ACUTE MYOCARDIAL INFARCTION PATIENTS TREATED WITH PCI: INSIGHTS FROM THE TRANSLATE-ACS STUDY
Authors: Emil L. Fosbol, Eric Peterson, Emily Honeycutt, Marjorie Zettler, John Messenger, Ron Waksman, Mark Effron, Paul Vaitkus, David Cohen, Tracy Wang
Journal: Journal of the American College of Cardiology (2013)