tbuckley/cabot-search huggingface dataset:
Trimodality Therapy Including Radical Resection for Pancoast Tumors: T4 is not a Contraindication for Radical Surgery
Authors: M.A. Hoda, R. Waseda, T. Klikovits, O. Foesleitner, S. Zoechbauer-Mueller, K. Dieckmann, H. Prosch, R. Pirker, W. Klepetko
Journal: Annals of Oncology (2015)
Effect of a Nutritional Supplement Containing Vitamin E, Selenium, Vitamin C and Coenzyme Q10 on Serum PSA in Patients with Hormonally Untreated Carcinoma of the Prostate: A Randomised Placebo-Controlled Study
Authors: K.M.J.L.F. Hoenjet, P.C. Dagnelie, K.P.J. Delaere, N.E.G. Wijckmans, J.V. Zambon, G.O.N. Oosterhof
Journal: European Urology (2004)
THE THERAPEUTIC SIGNIFICANCE OF PLASMA PROTEIN REPLACEMENT IN SEVERE BURNS
Authors: ROBERT ELMAN
Journal: JAMA (1941)

Of the 5,000 deaths each year in the United States attributed to the effect of severe burns, many could undoubtedly be avoided by adequate replacement therapy in this serious type of injury. An excellent clinical lecture on the treatment of burns is the recent one by McClure;<sup>1</sup>he has discussed the various theories of the etiology of death, among which are hepatic insufficiency, infection, toxemia, adrenal insufficiency and, finally, the theory which explains most of the general manifestations on the idea that there is an extensive loss of protein. It is this last aspect of the problem which I believe is the most important and which I wish to emphasize. This is of particular practical importance since it concerns the type and amount of fluids that are administered to a severely burned patient. It will be part of my purpose to present observations indicating that the type of fluid
Identification and partial characterization of a hepatocyte-derived factor promoting proliferation of cultured fat-storing cells (parasinusoidal lipocytes)
Authors: Axel M. Gressner, Sina Lotfi, Gabriele Gressner, Birgit Lahme
Journal: Hepatology (1992)

The molecular and cellular mechanisms of activation of fat-storing cells (Ito cells or parasinusoidal lipocytes), a prerequisite of the fibrogenic response of injured liver, were studied by analysis in vitro of some aspects of the intercellular communication between parenchymal liver cells and fat-storing cells. Conditioned medium harvested from early serum-free monolayer cultures of hepatocytes isolated from normal rat liver stimulated strongly, reproducibly and dose-dependently the proliferation of nonconfluent fat-storing cells maintained under serum-reduced conditions. During exposure of fat-storing cells for 48 hr to the conditioned medium, the incorporation of [3H]thymidine into DNA was stimulated four to six times over control values, the DNA content per culture well was elevated by 40% above control values and the immunocytochemical detection of bromodeoxyuridine-labeled cell nuclei was increased from 13% stained nuclei in controls to 70% stained nuclei in treated fat-storing cells. The mitogenic effects of hepatocyte-conditioned medium were similar to or even higher than those of 10% fetal calf serum. No mitoinhibitory activity could be detected in the hepatocyte-conditioned medium when arginase, as a potential inhibitor, was excluded. Rat skin fibroblasts could not be stimulated under conditions where the proliferation activity of fat-storing cells was greatly enhanced. The occurrence of the mitogenic activity in the medium is not dependent on de novo synthesis or secretion because the media of hepatocytes cultured under anoxic conditions in the presence of cycloheximide, brefeldin A or ethylenediaminetetraacetate were highly active in promoting fat-storing cell proliferation, although hepatocyte viability was greatly reduced under some of these conditions. A significant positive correlation (r = 0.95, p < 0.01) was found between lactate dehydrogenase activity and the mitogenic potency of the conditioned medium. The proliferation factor for fat-storing cells could also be demonstrated in the lysate of freshly isolated hepatocytes from normal liver. The stimulatory activity in the medium was partially enriched by a combination of gel permeation and anion exchange fast protein liquid chromatography and characterized as a protein with an apparent molecular weight of about 60 kD that is heat and pH sensitive but insensitive to reducing agents. It does not bind to immobilized heparin; nor does soluble heparin or proteinase inhibitor affect the mitogenic activity of the factor.(ABSTRACT TRUNCATED AT 400 WORDS)
Doctors should be alert to needs of patients who may have been trafficked, conference hears
Authors: L. Eaton
Journal: BMJ (2009)

Doctors need to be alert to the risk that some of the non-UK patients they see could have been trafficked and to act sensitively if they think that this may be the case, a psychiatrist has warned.

“The last thing they should do is pick up the phone and ring the police,” said Melanie Abas, senior lecturer in international mental health at the Institute of Psychiatry, King’s College, London.

Dr …
Will primary care trusts lead to US-style health care?
Authors: A. M Pollock
Journal: BMJ (2001)

The use of private finance in primary care premises has seen the entry of commercial property developers and for-profit healthcare companies, paralleling developments in the NHS hospital sector.1 As funding for capital investment in the NHS has become more complex, with the requirement that public-private partnerships generate a mixture of state and commercial revenues, the risks and costs of investment make general practitioners' ownership of premises increasingly unlikely.1 At the same time, the government's NHS Plan expects a rapid move of general practitioners into a salaried service, the end of independent contractor status, and an increasing role for the private sector.2 These changes raise questions about how government policy will affect the control of clinical decision making in managing NHS budgets and the core principles of the NHS. In this article I examine these issues from the perspective of the duties imposed by the NHS Plan on primary care trusts, which are the new NHS structures for health and social care, and show how the Health and Social Care Bill 2000 could move the United Kingdom towards a US-style health care system.

#### Summary points

For the first time, an NHS body will be able to charge for personal care and hotel costs

Government guidance on intermediate care restricts entitlement to NHS care to six weeks except in exceptional circumstances

NHS reimbursement mechanisms are being altered in ways that facilitate a shift to personal insurance rather than social insurance and universal coverage

By 2007, NHS trusts will have to find £4.5bn from annual revenue allocations to service debt incurred by using private finance and capital charges

The incentive structure of the new system will force care trusts to find ways of constraining expenditure through rationing, user charges, and commercial activities

If the principles of the NHS are to be upheld, …
HLA class II molecules and drug-induced idiosyncratic liver disease. A multicenter study
Authors: R.J. Andrade, M.I. Lucena, R. Benitez, A. Alonso, M. Garcia-Cortes, E. Garcia-Ruiz, M.C. Fernandez, L. Rodrigo, J. Salmeron, M. Jimenez-Saenz, J.A. Duran, M. Romero, J.M. Navarro, M. Jimenez
Journal: Journal of Hepatology (2003)
Natural history of reflux oesophagitis: a 10 year follow up of its effect on patient symptomatology and quality of life.
Authors: N I McDougall, B T Johnston, F Kee, J S Collins, R J McFarland, A H Love
Journal: Gut (1996)

BACKGROUND--Although oesophagitis is the most common diagnosis made at upper gastrointestinal endoscopy, data on the longterm outcome of affected patients are sparse. AIMS--This study assessed the level of reflux symptoms, quality of life, drug consumption, and complications in patients at least 10 years after diagnosis of oesophagitis at one centre. PATIENTS--One hundred and fifty two patients with typical reflux symptoms and a first time diagnosis by endoscopy of grade I-III oesophagitis between 1981 and 1984, were followed up using a postal questionnaire and telephone interview. RESULTS--Eighteen of 152 patients had died, 33 failed to respond, and 101 replied (mean follow up 11 years, range 121-160 months). Over 70% of patients still had heartburn at least daily (32%) or weekly (19%) or required daily acid suppression treatment (20%). Two patients (2%) had developed oesophageal strictures and one had Barrett9s oesophagus. Two of eight quality of life scores (physical function and social function) measured by the Short Form-36 were significantly lower than Northern Ireland population scores. CONCLUSION--Nearly three quarters of patients previously diagnosed as having oesophagitis still had significant morbidity related to gastro-oesophageal reflux disease more than 10 years after diagnosis. Some quality of life scores were significantly lower than those of the general population.
Extraction and Properties of Apple Allergens
Authors: Fred Björkstén, Liisa Halmepuro, Matti Hannuksela, Arto Lahti
Journal: Allergy (1980)

It is shown that apple allergens are probably proteins and that they can be extracted in an active form only if reactions with phenolic compounds present in apple are inhibited. This is accomplished by incorporating chelators and solid polyvinylpolypyrrolidone in the extraction medium. Phenol, commonly used as a preservative, should not be added. With the RAST, serum-IgE antibodies capable of reacting with apple allergens were detected in 90% of patients with clinical apple allergy, in 44% of patients with clinical birch-pollen allergy and in 5-10% of patients with other atopic allergies. RAST inhibition indicated that apple and birch-pollen allergens cross-react.
THE FORMATION OF MYELOMA PROTEIN BY A MOUSE PLASMA CELL TUMOR
Authors: Daniel Nathans, John L. Fahey, Michael Potter
Journal: The Journal of Experimental Medicine (1958)

The origin of the myeloma protein found in mice bearing the plasma cell tumor X5563 has been investigated. Specific activity-time curves of the myeloma proteins isolated from the tumor and from the plasma of these animals were compared following intravenous injection of L-lysine-C(14). The results indicate that myeloma protein is synthesized in the plasma cell tumor.
Gain-of-function ADAMTS13 variants that are resistant to autoantibodies against ADAMTS13 in patients with acquired thrombotic thrombocytopenic purpura
Authors: Cui Jian, Juan Xiao, Lingjie Gong, Christopher G. Skipwith, Sheng-Yu Jin, Hau C. Kwaan, X. Long Zheng
Journal: Blood (2012)
Biomechanical analysis of the jump serve in men's volleyball
Authors: M Häyrinen, T Mikkola, P Honkanen, P Lahtinen, A Paananen, M Blomqvist
Journal: British Journal of Sports Medicine (2011)

Background The most used serve technique in men's top volleyball is jump serve (JS). The efficiency of JS is related to the ball velocity (BV) of the serve. BVs have increased lately and thus a biomechanical analysis of JS was justified to investigate which elements have the biggest influence to BV of JS. Setting and participants Six players of the Finnish men's national volleyball team (23.40±2.28 years, 196.50±1.52 cm, 90.67±1.63 kg) served as subjects. Methods 3D-motion analysis (100 Hz) was made from two of the each player's JSs (the fastest (FS) and one slower serve (SS)). T test for paired samples was used to compare the velocities of FS and SS. Analysis of variance was applied to compare JSs in which the velocity was over 30 m/s (+30S) and under 30 m/s (−30S). The relationships between motion analysis variables and BV in all JSs were examined using Pearson's correlation coefficient. Results The most essential variables in which statistically significant differences between FS and SS and velocities +30S and −30S were found were: the position of the ball and the centre of gravity of the body at the time of the ball contact, the minimum angle and the maximal angle velocity of the thigh-trunk joint, the maximal forward velocities of the shoulder, elbow and wrist joints of the hitting hand and forward velocities of the elbow and wrist joints and middle finger at the time of the ball contact. The same variables correlated significantly with BV. Conclusions These findings suggest that in JS a successful throw is crucial in achieving higher BVs. Furthermore good power production abilities in the core, shoulder and arm and optimal function of the kinetic chain are important elements. The mobility of the hip joint and the thoracic vertebrae are also important factors in achieving high BVs.
Benign Chondroblastoma of Talus Demonstrated by Skeletal Scanning
Authors: SIDNEY ULREICH, GEORGE SWARTZ, STEVEN A. STIER, ELLEN PHILIPS
Journal: Clinical Nuclear Medicine (1978)

A patient with a benign chondroblastoma of the talus bone is described. A review of the pathogenesis and more common sites of predilection of this unusual tumor is presented. This is the first case, to our knowledge, shown by labeled phosphate scanning.
Abstract 3392: Molecular determinants for the bone-metastatic potential of prostate cancer cells
Authors: Qingxin Liu, Danielle Jernigan, Alessandro Fatatis
Journal: Cancer Research (2012)

Abstract Skeletal metastasis is the major cause of morbidity and death in patients with advanced prostate cancer (PCa). The propensity of cancer cells to progress into macroscopic lesions at secondary sites relies on the successful adaptation of Disseminated Tumor Cells (DTCs) to the new microenvironment. This requirement explains the predilection of most tumors to produce clinical metastases in selected organs although they can seed malignant cells also in several other tissues. It seems plausible that the metastatic fate of DTCs is dictated by the pleiotropic effects of specific genes and their encoded products establishing functional interactions with the surrounding stroma. The main objective of this study was to identify these molecular mediators of cell survival and growth in the bone with the ultimate goal of identifying effective therapeutic targets to counteract PCa metastases. Using a pre-clinical animal model of experimental metastasis, we have recently shown that exogenous over-expression of PDGFRα in non-metastatic prostate phenotypes conferred bone-metastatic potential and a monoclonal antibody targeting the receptor reduced bone metastatic tumors by more than 70%. Here we report that comparative gene-expression analyses conducted with PCa cells showing different intrinsic metastatic potential, as well as prostate phenotypes that fail to increase their metastatic behavior upon PDGFRα expression, resulted in a bone-metastatic gene signature including three genes encoding for soluble, secreted proteins. This suggests that DTCs with aggressive metastatic behavior modify the bone microenvironment in their favor, not only coercing the stroma to support their own survival, but also allowing other malignant phenotypes, that would otherwise fail to thrive, to grow into macroscopic tumors. We are currently testing this cell-cooperation in metastasis as well as functionally validating our three-gene signature by stably silencing or over-expressing each of the three newly identified genes in bone-metastatic and non-metastatic PCa cells, respectively. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 103rd Annual Meeting of the American Association for Cancer Research; 2012 Mar 31-Apr 4; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2012;72(8 Suppl):Abstract nr 3392. doi:1538-7445.AM2012-3392
Spanish abortion clinics close amid safety fears for women and doctors
Authors: Jane Burgermeister
Journal: BMJ (2008)

Only emergency abortions were performed in Spain last week after clinic staff went on strike, demanding greater legal protection for women and doctors.

More than 2000 women were affected when private clinics, which carry out 98% of all abortions in Spain, closed their doors, according to a report in El Pais (8 January; www.elpais.com/articulo/sociedad/Paro/historico/centros/aborto/elpepisoc/20080108elpepisoc_3/Tes).

In Andalusia, where state clinics do not carry out abortions, only emergency abortions were available at private clinics between 8 and 12 January.

“We will take care of women sent to us by public …
AN EXTRACEREBELLAR TUMOR
Authors: EDWARD L. MOORHEAD
Journal: JAMA (1910)

Extracerebellar tumors lie in the cerebello-pontine recess. They apparently arise from the acoustic nerve; usually grow slowly and it may he years before symptoms, produced by pressure on the lateral lobe of cerebellum and pons, to which they are adherent, appear. This case was referred to me May 23, 1910: <h3>History.—</h3> Mr. R. W., aged 58, married, a car-repairer, born in Switzerland, had lived in America thirty years. His health had always been good. There was no specific history. Two years ago he had a discharge from the right ear which continued for about two weeks. He began to complain of deafness in the left car about three years ago. Two years ago, he was struck under the right eye by a jack-handle, causing some swelling and discoloration. In February, 1910, he began to complain of being dizzy when he would stoop over. There was headache and a sense of fulness
The significance of baseline serum alanine aminotransferase on pretreatment disease characteristics and response to antiviral therapy in chronic hepatitis C
Authors: Stuart C. Gordon, Jane W. Fang, Ann L. Silverman, John G. McHutchison, Janice K. Albrecht
Journal: Hepatology (2000)

We sought to determine whether pretreatment serum alanine aminotransferase (ALT) levels in patients with chronic hepatitis C virus (HCV) correlate with demographic features and other disease characteristics and whether these values influence response to therapy. A total of 1,744 patients with HCV received either interferon alfa-2b and placebo or combination interferon alfa-2b and ribavirin for 24 or 48 weeks. Of these, 105 individuals (6%) had minimally raised serum ALT determinations at entry visit of ≤1.3 × the upper limit of normal (ULN). By analysis of variance both pretreatment histologic activity index (HAI) scores ( P &lt; .0001) and fibrosis scores ( P = .003) were significantly lower among patients with baseline ALT levels ≤1.3 × ULN. Individuals with lower pretreatment ALT values were younger and weighed less than the ALT &gt;1.3 × ULN cohort. Baseline ALT was not related to gender, race, baseline viral level, or HCV genotype. Using logistic regression analysis, the only demographic feature associated with ALT ≤1.3 × ULN was lower baseline weight and lower baseline HAI score. There was no difference in sustained response between patients with baseline ALT levels ≤1.3 × ULN and those with &gt;1.3 × ULN, in all treatment groups (26 of 105, 24.8% for ALT ≤1.3 × ULN; 440 of 1,639, 26.8% for ALT &gt;1.3 × ULN). We conclude that HCV patients with minimally raised ALT values (≤1.3 × ULN) weigh less, and have lower histologic inflammatory scores than patients with more conventionally elevated ALT levels. Despite these differences, these patients have a similar sustained response to antiviral therapy.
Relationship Between Hyperglycemia and Cognitive Function in Older NIDDM Patients
Authors: Gerald M Reaven, Larry W Thompson, David Nahum, Edmund Haskins
Journal: Diabetes Care (1990)

The nature and extent of cognitive impairment was examined in 29 healthy elderly subjects (mean age 69.8 yr) with non-insulin-dependent diabetes mellitus (NIDDM) and 30 demographically similar nondiabetic community volunteers (mean age 68 yr). Measures of verbal learning, abstract reasoning, and complex psychomotor functioning were performed more poorly by diabetic than nondiabetic subjects. Conversely, there were no between-group differences in performance on tasks involving pure motor speed and simple verbal abilities. Within the diabetic group, individuals with poorer metabolic control performed more poorly on tasks involving learning, reasoning, and complex psychomotor performance, although this relationship was not evident for simple verbal or motor tasks. These data indicate that older people with NIDDM who are functioning well and perceive themselves as in good health are likely to manifest greater deficits than healthy elderly people in processing complex verbal or nonverbal material. Possible explanatory mechanisms are discussed, and directions for future research are explored.
Targeted delivery of miR-200c/DOC to inhibit cancer stem cells and cancer cells by the gelatinases-stimuli nanoparticles
Authors: Qin Liu, Ru-Tian Li, Han-Qing Qian, Jia Wei, Li Xie, Jie Shen, Mi Yang, Xiao-Ping Qian, Li-Xia Yu, Xi-Qun Jiang, Bao-Rui Liu
Journal: Biomaterials (2013)
The RFX Complex Is Crucial for the Constitutive and CIITA-Mediated Transactivation of MHC Class I and β2-Microglobulin Genes
Authors: Sam J.P Gobin, Ad Peijnenburg, Marja van Eggermond, Marlijn van Zutphen, Rian van den Berg, Peter J van den Elsen
Journal: Immunity (1998)
The telephone rings...
Authors: V. Mahendrayogam
Journal: BMJ (2010)

The telephone call begins innocuously enough: “Hello, can I speak to Mr Smith please?” Now Mr Smith may or may not be there, but generally the reply is “Who’s calling?” 

This is usually followed by an awkward silence as I am still new to this game. I then say something like, “I’m sorry, but I need to speak to Mr Smith directly.”

I wait for the response, and then it begins. They want to know who I am and why I want to speak to their husband/wife/daughter/son. As a family member, they feel that they have a right to know. I try to deflect …
Some auto-injection pens are counterintuitive
Authors: P. L. Madsen, N. Mattsson
Journal: BMJ (2009)

Type I allergy carries the risk of incorrect self treatment.1 In patients with type I allergy and established systemic reactions, treatment includes self injection of adrenaline with prefilled devices—the EpiPen device is constructed to look like a ballpoint pen. Unfortunately it is constructed as an upside-down pen: the needle emerges from …
Urban hypothermia: preferred temperature and thermal perception in old age.
Authors: K J Collins, A N Exton-Smith, C Dore
Journal: BMJ (1981)

A study of 17 elderly men and 13 young adults of similar body build and wearing equivalent clothing insulation (0.8 clo) showed that when given control over their environment the elderly preferred the same mean comfort temperature (22-23 degrees C) but manipulated ambient temperature much less precisely than the young. Slow adjustment of ambient temperature was related to some cases to a higher temperature-discrimination threshold. These findings suggest that both physiological and behavioural changes contribute to the increased vulnerability of old people in cold conditions.