Gentamicin and Neuromuscular Blockade
Authors: JORDAN L. HOLTZMAN
Journal: Annals of Internal Medicine (1976)

Letters1 January 1976Gentamicin and Neuromuscular BlockadeJORDAN L. HOLTZMAN, M.D., PH.D.JORDAN L. HOLTZMAN, M.D., PH.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-84-1-55_1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptNeuromuscular blockade is a major toxicity of amino-glycoside antibiotics (1, 2). Yet gentamicin has only rarely been associated with blockade (3, 4). Warner and Sanders (3) reported on a patient who had 14 days of gentamicin and then a laparotomy during which he received curare. Forty-eight hours later he had respiratory arrest attributed to gentamicin neuromuscular blockade. Similarly Hall and associates (4) reported on a uremic patient who had neuromuscular blockade after tubocurarine, lidocaine, and gentamicin, suggesting an additive effect of these agents (5). We recently observed a patient with severe Parkinson's disease who on two occasions exhibited a profound...References1. MOLITORGRAESSLE HO: Pharmacology and toxicology of antibiotics. Pharmacol Rev 2:1-60, 1950 Google Scholar2. BRAZILCORRADO OA: The curariform action of streptomycin. J Pharmacol Exp Ther 120:452-459, 1957 MedlineGoogle Scholar3. WARNERSANDERS WE: Neuromuscular blockade associated with gentamicin. JAMA 215:1153-1154, 1971 CrossrefMedlineGoogle Scholar4. HALLMCGIBBONEVANS DDC: Gentamicin, tubocurarine, lidocaine and neuromuscular blockade. Br J Anaesth 44:1329-1332, 1972 CrossrefMedlineGoogle Scholar5. PARADELISTRIANTAPHYLLIDISFIDANI ACV: The action of the isolated rat diaphragm. Potentiation of the neuromuscular blocking activity of gentamicin during combined application with muscle relaxant agents and magnesium Arzneim Forsch 24:1772-1773, 1974 MedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byAminoglycoside antibioticsTobramycinAminoglycosidesOptimizing Aminoglycoside UseANTIBACTERIAL DRUGSAminoglycoside antibioticsTobramycinCompetitive and open channel block of recombinant nAChR channels by different antibioticsDoes once-daily dosing of aminoglycosides affect neuromuscular function?Acute massive gentamicin intoxication in a patient with end-stage renal diseaseAntibiotic use in the emergency department. II. The aminoglycosides, macrolides, tetracyclines, sulfa drugs, and urinary antisepticsProtection against gentamicin nephrotoxicity by daptomycin in nephrectomized ratsAntitubercular drugsPharmacological principles and kineticsHuman safety and pharmacokinetics of a single intramuscular dose of a novel spectinomycin analog, trospectomycin (U-63,366F)Aminoglycoside antibiotic agents: a reviewVentilator Dependence, Hypotonia, Hypocalcemia, and Aminoglycoside TherapyCIRCADIAN AND CIRCANNUAL CHANGES IN NEPHROTOXIC EFFECTS OF HEAVY METALS AND ANTIBIOTICSChemotherapy of InfectionThe Neurotoxicity of Antibacterial AgentsSHARON R. SNAVELY, M.D., GLENN R. HODGES, M.D.Gram-negative sepsisMiopatia por propoxifeno: relato de 2 casos com histoquimica de músculosA myasthenia-like syndrome and polyneuropathy, complications of gentamicin therapyGentamicin in 1978GERALD B. APPEL, M.D., HAROLD C. NEU, M.D., F.A.C.P.In Vitro Activity of Netilmicin Compared with Gentamicin, Tobramycin, Amikacin, and KanamycinOther antibiotic drugs 1 January 1976Volume 84, Issue 1Page: 55-55KeywordsAntibioticsLaparotomyNeuromuscular blockadeParkinson diseaseToxicity Issue Published: 1 January 1976 PDF downloadLoading ...