PANHYPOPITUITARISM AND HYPOCALCEMIC TETANY IN A MALE: CASE PRESENTATION
Authors: J J RUPP, K E PASCHKIS
Journal: Annals of Internal Medicine (1953)

Case Reports1 November 1953PANHYPOPITUITARISM AND HYPOCALCEMIC TETANY IN A MALE: CASE PRESENTATIONJ. J. RUPP, M.D., KARL E. PASCHKIS, M.D.J. J. RUPP, M.D.Search for more papers by this author, KARL E. PASCHKIS, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-39-5-1103 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptLesions of the anterior pituitary gland which prevent the elaboration of the pituitary trophic hormones (adrenocorticotropin, thyrotropin and the gonadotropins) will produce hypothyroidism, hypoadrenocorticalism and hypogonadism, the syndrome of severe panhypopituitarism. This syndrome is rare. Ninety-five confirmed cases of severe panhypopituitarism have been collected from the world literature by Sheehan and Summers.1 In his monograph on extreme insufficiency of the adenohypophysis, Farquharson2 listed 92 cases collected from the world literature, of which 57 cases presented the typical syndrome.The following lesions of the pituitary gland have been reported as causes of panhypopituitarism: postpartum necrosis, tumors and cysts, trauma, "spontaneous atrophy...Bibliography1. SheehanSummers HLVH: The syndrome of hypopituitarism, Quart. J. Med. 18: 319, 1949. MedlineGoogle Scholar2. Farquharson RF: Simmonds' disease—extreme insufficiency of the adenohypophysis, 1950, Charles C Thomas, Springfield, Ill. Google Scholar3. HoltorffKoch AFFC: The colorimetric estimation of 17-ketosteroids and their application to urine extracts, J. Biol. Chem. 135: 377, 1940. CrossrefGoogle Scholar4. CutlerPowersWilder HHMHRM: Concentration of sodium chloride and potassium in the blood plasma and urine of patients with Addison's disease: their diagnostic significance, Proc. Staff Meet., Mayo Clin. 13: 244 (Apr.) 1938. Google Scholar5. DaughadayWilliamsDaland WHRHGA: The effects of endocrinopathies on the blood, Blood 3: 1342, 1948. CrossrefMedlineGoogle Scholar6. WatkinsonMcMenemeyEvans GWHG: Hypopituitarism, hypogonadism, and anemia treated with testosterone. Lancet 1: 631, 1947. CrossrefMedlineGoogle Scholar7. Crafts RG: The effects of cobalt, liver extract, and vitamin B12 on the anemia induced by hypophysectomy in adult female rats, Blood 7: 863, 1952. CrossrefMedlineGoogle Scholar8. CantopoulosVan DykeSimpsonGarciaHuffWilliamsEvans ANDCMEJFRLBSHM: Increase in circulating red cell volume after oral administration of pituitary anterior lobe, Blood 8: 131, 1953. CrossrefMedlineGoogle Scholar9. AlbrightReifenstein FEC: Parathyroid glands and metabolic bone disease, 1948, The Williams and Wilkins Co., Baltimore. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Philadelphia, Pennsylvania*Received for publication May 20, 1953.From the Division of Endocrine and Cancer Research, Jefferson Medical College, Philadelphia. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byAutoimmune HypophysitisPrimary hypophysitis and other autoimmune disorders of the sellar and suprasellar regionsRevisitation of autoimmune hypophysitis: knowledge and uncertainties on pathophysiological and clinical aspectsUse of serum pituitary antibodies to improve the diagnosis of hypophysitisAutoimmune HypophysitisPituitary AutoimmunityThe Effect of Growth Hormone on Urinary Calcium ExcretionHypophysitisAutoimmune HypophysitisLymphocytic adenohypophysitis: A pituitary mass lesion occurring in pregnancyAdrenal Autoimmunity and Autoimmune Polyglandular SyndromesAuto-immunity of the Anterior PituitaryThe Association of Diabetes Insipidus with Hypoparathyroidism, Addison's Disease and Mucocutaneous CandidiasisThe ParathyroidsHYPOPARATHYROIDISM AND HYPOPITUITARISMTHE SYNDROME OF HYPOPARATHYROIDISM, ADDISION'S DISEASE AND MONILIASISIdiopathic hypoparathyroidism and Addison's disease 1 November 1953Volume 39, Issue 5Page: 1103-1106KeywordsAdrenocorticotropic hormoneGonadotropinsHypogonadismHypothyroidismLesionsNecrosisPanhypopituitarismPituitary glandProlactinThyroid-stimulating hormone ePublished: 1 December 2008 Issue Published: 1 November 1953 PDF downloadLoading ...