tbuckley/cabot-search huggingface dataset:
Social Constriction in Psychiatric Patients: A Normative Study
Authors: W. DEREK SHOWS, W. DOYLE GENTRY, LINDA C. WYRICK
Journal: American Journal of Psychiatry (1974)

The authors analyzed scores on the Bates-Zimmerman Social Constriction Scale and the Minnesota Multiphasic Personality Inventory (MMPI) administered to 132 psychiatric inpatients. Neurotic patients evidenced a higher level of social constriction than did patients with psychophysiologic disorders; no significant differences were found among the other diagnostic groups. Social constriction was found to be positively related to scores on the MMPI hypochondriasis, depression, psychasthenia, schizophrenia, social introversion, anxiety, repression, and F scales; constriction was negatively related to scores on the L, K, mania, and ego strength scales. The authors suggest that social constriction is specifically related to behavioral traits, irrespective of diagnostic labels, and that the Bates-Zimmerman Scale should be given wider use in diagnostic consultation.
Heme Oxygenase-2 and Large-Conductance Ca<sup>2+</sup>-activated K<sup>+</sup> Channels
Authors: Markus Roth, Markus Rupp, Simone Hofmann, Manish Mittal, Beate Fuchs, Natascha Sommer, Nirmal Parajuli, Karin Quanz, Dominic Schubert, Eva Dony, Ralph Theo Schermuly, Hossein Ardeschir Ghofrani, Ulrike Sausbier, Katrin Rutschmann, Sarah Wilhelm, Werner Seeger, Peter Ruth, Friedrich Grimminger, Matthias Sausbier, Norbert Weissmann
Journal: American Journal of Respiratory and Critical Care Medicine (2009)

Rationale: Hypoxic pulmonary vasoconstriction (HPV) is an important mechanism by which pulmonary gas exchange is optimized by the adaptation of blood flow to alveolar ventilation. In chronic hypoxia, in addition to HPV a vascular remodeling process leads to pulmonary hypertension. A complex of heme oxygenase-2 (HO-2) and the BK channel has been suggested as a universal oxygen sensor system.Objectives: We investigated whether this complex serves as an oxygen sensor for the vascular effects of alveolar hypoxia in the lung.Methods: The investigations were performed in chronically hypoxic mice, in isolated perfused and ventilated lungs, and on the cellular level, including HO-2- and BK-channel deficient mice.Measurements and Main Results: Immunohistochemical analysis of mouse lungs identified HO-2 mainly in pulmonary arteries, the bronchial epithelium, and alveolar epithelial cells. BK channel α-subunit (BKα) immunoreactivity was found primarily in the bronchial and vascular smooth muscle layer. Immunofluorescence staining and coimmunoprecipitation suggested only a weak complexation of HO-2 and BKα in pulmonary arterial smooth muscle cells. The strength of acute and sustained HPV, determined in isolated perfused and ventilated lungs, was not different among wild-type, HO-2–deficient, and BKα-deficient mice. Exposure of mice to 3 weeks of chronic hypoxia resulted in a slight down-regulation of HO-2 and no alteration in BKα expression. The degree of pulmonary hypertension that developed, quantified on the basis of right ventricular pressure, right-heart hypertrophy, and the degree of muscularization of precapillary pulmonary arteries, was not different among wild-type, HO-2–deficient, and BKα-deficient mice.Conclusions: It is demonstrated that neither deletion of HO-2 nor BK channels affect acute, sustained, and chronic vascular responses to alveolar hypoxia in the lung.
Stimulatory Effect of Immunization on Tumor Induction by Moloney Murine Sarcoma Virus2
Authors: Donna M. Murasko, Richmond T. Prehn
Journal: JNCI Journal of the National Cancer Institute (1978)

Adult mice were immunized with varying doses of inactivated Moloney murine leukemia virus (M-MuLV). Eight weeks after immunization, mice were challenged with a dose of Moloney murine sarcoma virus (M-MuSV) that could induce tumors in approximately 50% of normal animals. Mice immunized with high doses of M-MuLV (10(10) particles) had significantly decreased tumor incidences, whereas mice immunized with low doses of M-MuLV (10(2) particles) had significnatly increased tumor incidences compared to those in nonimmunized controls. The stimulatory effect could be abrogated by the irradiation of mice with 450 rads 24 hours prior to M-MuSV challenge, whereas the inhibitory effect was resistant to this irradiation procedure. The results suggested that immunization with virus can either stimulate or inhibit virus-induced tumorigenesis, depending on the dose of virus used for immunization.
Results in a tobacco cessation unit in Albacete University Hospital during 2010
Authors: Francisco Javier Callejas Gonzalez, Javier Cruz Ruiz, Sergio Garcia Castillo, Ana Isabel Tornero Molina, Marta Genoves Crespo, Angel Molina Cano, Abel Jesus Martinez Garcia, Juan Pastrana Calderon, Claudia Rossana Rodriguez Ortega
Journal: European Respiratory Journal (2014)

Introduction: Tobacco is the leading cause of preventable disease and death in the world. Therefore it is essential that smokers quit smoking.  Aims and Objectives: Results obtained in a Tobacco Cessation Unit in 2010.  Material and Methods: Retrospective descriptive analysis of the results obtained from patients who were attended to in a Tobacco Cessation Unit from 1st. January to 31st. December 2010 and subsequent follow-up to complete a year.  Results: 314 of 462 patients (50,6% males); 158 patients started treatment (55,7% females) and only 71 (44,9%) completed it, mean age 47,1 years and mean cigarettes/day 24,6. Moderate nicotine dependence (Fagerstrom 5,9) and high motivation (Richmond 8,2). Respiratory comorbidity, 31,6%: 15,2% COPD, 7,6% asthma, 7,6% OSAHS, 2,5% Tuberculosis, 0,6% Home Oxigen Therapy and 1,3% Interstitial Lung Disease; Cardiac, 3,2%: Ischemic Cardiophaty, 2,5%, Arrhytmia, 3,8% and Hearth Failure, 2,5%; CVRF: 29,7% dyslipidemia, 21,5% HT and 8,2% DM. 44,9% psychiatric comorbidity, 41,8% depression and/or anxiety. 10,1% without treatment, 30,4% Nicotine Replacement Therapy (TSN), 14,6% bupropion (BUP), 34,8% varenicline (VRN), 3,1% TSN + BUP, 5,1% TSN + VRN, 1,3% VRN + BUP and 0,6% TSN + VRN + BUP . Of the 158 patients treated, success (one year without smoking) in 53 (33,5%), 18 males and 35 females, and failure, considered as abstinence never, in 20 (12,7%), 12 males and 8 females.  Conclusions: 1. 65,81% did not start treatment (32,04% and 33,77%, first and second appointment respectively). 2. Moderate nicotine dependence and high motivation. 3. Severe comorbidity, especially psychiatric, respiratory and CVRF. 4. Treatment success in 53 patients (33,5%) and failure in 20 (12,7%).
Advances in Muscular Dystrophies
Authors: Peter B. Kang, Robert C. Griggs
Journal: JAMA Neurology (2015)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Neurology HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Neurology journal
The impact of sublingual allergen-specific therapy on asthma control and quality of life
Authors: Dmitry Nagatkin, Alexandr Zhestkov, Julia Bogdanova, Olga Nagatkina
Journal: European Respiratory Journal (2014)

The sublingual allergen-specific therapy (SLIT) is the most perspective method of pathogenic therapy of allergic asthma. Unfortunately, there are very few studies concerning the influence of SLIT on asthma control.  The aim of our work was to find out whether SLIT improves notably the asthma control and quality of life of patients with allergic asthma and sensitization to pollen of trees.  We enrolled 37 patients with mild or moderate asthma, each of them had a skin prick tests positive to pollen of a birch, alder or hazel. Patients were divided into two groups, similar in initial asthma control level, asthma severity, gender and sex: the 1 st  group (18 patients) - received SLIT to birch, alder and hazel allergens and the 2 nd  group - did not have this benefit. We evaluated the control level by ACT test and ACQ-5 test, quality of life by SF-36 and mean dose of inhaled corticosteroids (ICS) before and after SLIT. We used a standardized index of reactivity allergens.  We observed significant difference in the average dose of ICS before and after the research at the 1 st  group: 513.15 mg per day initially and 355.22 mg per day after SLIT (p 1  data, ACQ-5 and ACT™ test results. Patients of the 2 nd  group had significant differences in the FEV 1 , results of ACQ-5 and ACT™ tests and average ICS doses in comparison with the first group.We observed significant differences between two groups in all parameters of life quality level (p  Conclusion: We demonstrated a marked positive affect of SLIT on asthma control and life quality level of patients with sensitization to pollen of trees and mild or moderate asthma.
Satellite DNA Organization in the Chromosomes of Primary Cells, L-Cells, and Sarcoma Mouse Cells 2
Authors: N. O. Bianchi, Martha S. Bianchi, Lidia A. Vidal Rioja, Esther A. Lezana
Journal: JNCI Journal of the National Cancer Institute (1977)

Journal Article Satellite DNA Organization in the Chromosomes of Primary Cells, L-Cells, and Sarcoma Mouse Cells Get access N. O. Bianchi, N. O. Bianchi Search for other works by this author on: Oxford Academic PubMed Google Scholar Martha S. Bianchi, Martha S. Bianchi Search for other works by this author on: Oxford Academic PubMed Google Scholar Lidia A. Vidal Rioja, Lidia A. Vidal Rioja Search for other works by this author on: Oxford Academic PubMed Google Scholar Esther A. Lezana Esther A. Lezana Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 59, Issue 1, July 1977, Pages 113–118, https://doi.org/10.1093/jnci/59.1.113 Published: 01 July 1977 Article history Received: 17 May 1976 Accepted: 29 October 1976 Published: 01 July 1977
Not reading and signing letters you have dictated
Authors: T. Rimmer, M. Jones, T. Powell, J. Nottingham, P. Lindstrom, J. C McIlwain, T L James, A. Midgley, J. Doherty, L. Crossan
Journal: BMJ (2001)

Editor—Shere writes that not reading and signing letters you have dictated may be dangerous, but I disagree with most of most of what he says.1 Perhaps some other doctors do not have as many letters to sign as I do: to scrutinise and sign every routine clinic letter would mean that I would no longer be able to keep my head above the paperwork. Dreary work is bearable if it is useful, but what is the return for checking routine letters for the odd spelling mistake? Shere mentions a mistyped drug dose error that could have been lethal. No doctor should base his or her drug doses solely on another doctor's letter, signed or not.

A signed letter is certainly more courteous than an unsigned one, but I hope that general practitioners in my area realise that an unsigned letter was dictated with just as much courtesy, that my stress levels are kept in check by sending unsigned letters, and that unsigned letters will arrive more quickly. I would postulate that what general practitioners really do not like are long and unstructured letters in which it is difficult to pick out essential information such as diagnosis, treatment (lethal or otherwise), and when the next appointment is.

I started adding “Please accept unsigned to avoid delay” to my letters five years ago. That was some economy of the truth, I admit. But “Please accept this unsigned to avoid delay and because the prospect of unnecessarily signing 2000 or 3000 letters a year fills me with nausea and will bring on my early departure from the NHS” would not have struck the right tone.
Transbronchial node aspiration for intrathoracic lymphadenopathy
Authors: HamidReza Jabbardarjani, Arda Kiani, Mehdi Bakhtiar, Negar Sheikhi
Journal: European Respiratory Journal (2012)

Background and objectives:Lymph node evaluation has been important for many years both regarding diagnosis and staging.This study was aimed at evaluating the diagnostic yield of transbronchial needle aspiration biopsy (TBNA) in patients with intrathoracic lymphadenopathy.  Methods: Our understudy population included all patients suffering from undiagnosed intrathoracic lymphadenopathies (LAP)with no accompanying pulmonary lesions on chest CT scan who had referred to bronchoscopy unit of Masih Daneshvari Hospital. After determining the anatomic location of LAP,patients underwent fiberoptic bronchoscopy (FOB) and TBNA using 19-gauge eXcelon aspiration needle.Four samples were taken from each patient from the same LAP location.  Results: In this study 39 patients were evaluated.The most common anatomic location of LAP was the paratracheal area seen in 14 patients (45.2%),next was subcarinal area and also hilar area with 12 cases (38.7%) for each of them.Five patients (15.6%) had LAP in other anatomical locations.Evaluation of the aspirates obtained by TBNA showed that the sample was adequate and diagnostic in 21 patients (55.26%),adequate but non-diagnostic in 9 patients (23.68%) and inadequate in 8 cases (21.06%).Definite diagnosis was made in 22 patients among which the most common diagnosis was atypical and malignant lesions in 11 cases (50%) followed by sarcoidosis in 8 (36.36%),tuberculosis (TB) in 2 (9.09%) and other diagnoses in 1 (4.55%) case.  Conclusion: Based on our study results,TBNA was diagnostic in more than half the cases.Various studies have reported a wide range of results in this respect but all of them including ours emphasize on the acceptable diagnostic yield of this technique.
Efficacy of anticholinergic prophylaxis for neuroleptic-induced acute dystonia
Authors: George W. Arana, Donald C. Goff, Ross J. Baldessarini, George A. Keepers
Journal: American Journal of Psychiatry (1988)

The authors analyzed data from nine studies comparing the incidence of acute dystonia induced by neuroleptic agents with and without concomitant use of anticholinergic agents. Anticholinergic agents reduced the rate of dystonia by 1.9-fold in all patients treated with different neuroleptics and by 5- to 8-fold in patients treated with high-potency neuroleptics. In addition, the incidence of dystonia and the efficacy of anticholinergic prophylaxis were related inversely to age. These results support the efficacy of anticholinergic agents in preventing neuroleptic-induced dystonia, particularly in young male patients treated with high-potency neuroleptics.
Home antibiotic therapy for low-risk cancer patients with fever and neutropenia: a pilot study of 30 patients based on a validated prediction rule.
Authors: J A Talcott, A Whalen, J Clark, P P Rieker, R Finberg
Journal: Journal of Clinical Oncology (1994)

PURPOSE To assess the feasibility of early discharge to home therapy with standard intravenous antibiotics in 30 patients with fever and neutropenia at low risk by a validated clinical decision rule. PATIENTS AND METHODS Newly admitted outpatients with fever and neutropenia were evaluated for home therapy during 2 days of inpatient observation. To evaluate enrolled patients' acceptance of home care, we assessed patient attitudes and quality of life before and after home therapy. To assess economic effects, we compared the medical charges of patients treated at home with those of medically eligible patients who remained in the hospital. RESULTS Of the first 84 patients, 50 (60%) were medically ineligible, and neutropenia was resolved in another eight (10%) during the observation period. Only nine patients of the remaining 26 who were medically eligible (35%) were enrolled in the home-therapy trial. Thereafter, 21 of 31 medically eligible patients (68%) were enrolled. The 30 patients treated at home were neutropenic for a median of 6 days (mean, 8.2). Four had medical complications, and five others were readmitted for observation. Patients' quality of life improved during home therapy, and favorable attitudes toward home care persisted after treatment. Medically eligible patients not enrolled had briefer neutropenia than patients treated at home, but had 44% higher daily medical charges and equivalent overall charges despite treatment half as long. CONCLUSION We conclude that early discharge of low-risk patients to home intravenous antibiotic therapy is feasible, is well received by patients, and may prove to be cost-saving. However, these conclusions must be validated in a large randomized trial.
Long term outcome of 135 high grade non-Hodgkin’s lymphoma of the head and neck (HN NHL) treated with high dose CHOP regimen and involved field radiotherapy
Authors: L. Laccourreye, B. Desablens, C. Le Maignan, A. Le Mevel, C. Berthou, T. Lamy, C. Gandour, F. Guilhot, N. Ifrah, P. Colombat, None Goelams
Journal: Journal of Clinical Oncology (2006)

7550 Background: We present the results of a prospective study conducted by the GOELAMS group and evaluating long-term clinical outcome in a series of 135 patients with a HN NHL undergoing chemotherapy and radiotherapy. Methods: From 1986 through 1998, 135 patients aged from 17 to 69 years were enrolled in a prospective multicenter study for primary treatment of HN localized stage I/II high-grade NHL. Treatment regimen consisted in 3 VCAP + 40 Gy locoregional irradiation. Results: The median age was 48.5 years (17–69) with 36 patients being 60 or over. The main localization was Waldeyer’s ring (57) including tonsil (35), nasopharynx (14), whole Waldeyer (8), neck (49), nasal cavities (14), thyroid (8) salivary gland (5), mandibular bone (2). According to the WFC, histological subtype were as F (21%), G (57%) and H (20%) and unclassified (2%). Ann Harbor classification included 80 stage 1 and 55 stage II. The IPI score was 0 (49.7%), 1 (22.3%), 2 (10.4%), 3 (2.3%) undetermined (16.3%). PS&gt;2 and bulk (≥ 5 cm) were observed in 7.5% and 43% of patients respectively. 94% achieved CR. 2 patients died during treatment. Relapses occurred in 23/127 (18.1%) at a median time of 31 months (5.5–80). 16 of these relapses occurred before 3 years of CR, 5 between 3 and 6 years and 2 after 6 years of CR. With a median follow up of 65 month (7–146) OS and EFS were 81.5% and 77% respectively. In univariate analysis age≥ 60, extension, PS≥2, Bulk≥5 cm, erythrocyte sedimentation rate≥ 40, high serum LDH,IPI≥2 and salivary gland or panwaldeyer localization significantly decrease EFS (P = 0.055, 0.017, 0.006, 0.0001, 0.04, 0.028, 0.014 and 0.043 or 0.0001 respectively). In multivariate analysis only the bulk≥5 cm, the erythrocyte sedimentation rate≥40 and the localization to salivary gland significantly decrease EFS (P = 0.004, 0.004 and 0.033 respectively). Conclusions: This study underlines the high efficiency of this protocol in treating HN NHL. HN NHL localized to the salivary glands or with a bulk ≥ 5 cm should be included in new therapeutic trials in order to improve their outcome. No significant financial relationships to disclose.
Feasibility and results of bone marrow transplantation after remission induction and intensification chemotherapy in de novo acute myeloid leukemia. Catalan Group for Bone Marrow Transplantation.
Authors: J Sierra, S Brunet, A Grañena, T Olivé, J Bueno, J M Ribera, J Petit, C Besses, A Llorente, R Guardia, J Macía, M Rovira, I Badell, E Vela, C Díaz de Heredia, P Vivancos, E Carreras, E Feliu, E Montserrat, A Julía, J Cubells, C Rozman, A Domingo, J J Ortega
Journal: Journal of Clinical Oncology (1996)

PURPOSE To evaluate prospectively the feasibility and results of bone marrow transplantation (BMT) after induction and intensification chemotherapy (CT) in patients with de novo acute myeloid leukemia (AML). PATIENTS AND METHODS A total of 159 patients less than 51 years of age were treated. Induction CT consisted of daunorubicin 60 mg/m2 for 3 days, cytarabine (ARA-C) 100mg/m2 for 7 days, and etoposide 100 mg/m2 for 3 days. The first intensification therapy included mitoxantrone 10 mg/m2 for 3 days and ARA-C 1.2 g/m2 every 12 hours for 4 days. Amsacrine (100 or 150 mg/m2 for 3 days) and ARA-C (1.2 g/m2 every 12 hours for 2 or 4 days) were given as the second intensification therapy. Depending on the availability of a human leukocyte antigen (HLA)-identical sibling, the intention of treatment after CT was allogeneic BMT (allo-BMT) or autologous BMT (ABMT). RESULTS Complete remission (CR) was obtained in 120 patients (75%) and partial remission (PR) in 11 (7%), while 15 patients (10%) were refractory and 13 (8%) died during induction. There was a trend for better leukemia-free survival (LFS) at 4 years for patients assigned to the ABMT group (50% +/- 6%) compared with the allo-BMT group (31% +/- 7%) (P = .08). This difference in LFS reached statistical significance when considering only transplanted patients (63% +/- 3% at 4 years after ABMT and 38% +/- 11% after allo-BMT, P = .02). The favorable results in patients who received ABMT (no toxic deaths and 37% +/- 7% probability of relapse at 4 years) contrast with the poor outcome of allografted patients (11 patients with transplant-related mortality). CONCLUSION Our study reflects the difficulties in the completion of a therapeutic strategy that include BMT and suggests that intensification before BMT may be useful in the setting of ABMT, but this approach was associated with a high mortality rate in allo-BMT patients.
Unique characteristics of patients with pulmonary arterial hypertension associated with congenital heart disease compared to the rest of pulmonary arterial hypertension subgroups
Authors: George Giannakoulas, Sophia-Anastasia Mouratoglou, Alexandros Kallifatidis, Georgia Pitsiou, Ioannis Stannopoulos, Stavros Hadjimiltiades, Haralambos Karvounis
Journal: European Respiratory Journal (2014)

Purpose:To assess right ventricular (RV) function, dimensions, pressure and volume overload in patients with pulmonary arterial hypertension (PAH) associated to congenital heart disease (CHD-PAH) and in the rest of PAH subgroups (rPAH).  Methods: All patients underwent 6 minute walk test (6MWT) and cardiac magnetic resonance on the same day. Left ventricular eccentricity index in end-systole (LVEI systole) and end-diastole (LVEI diastole) were defined in the short-axis view at the level of papillary muscles.  Results:Our study included 9 patients with CHD-PAH and 16 with rPAH (11 idiopathic PAH, 5 PAH associated to connective tissue disease). All patients had preserved RV function and similar functional capacity as expressed through distance walked in 6MWT and NYHA classification. CHD-PAH patients had higher RV volume but not pressure overload when compared to rPAH. Although patients in both study groups had similarly dilated RV, RV hypertrophy was more prominent in CHD-PAH.  Conclusions:Although patients with CHD-PAH have more severely hypertrophied and volume overloaded RV, they retain good RV function. This may reflect the RV adaptations to long-standing increase of RV blood flow and pressure occurring in CHD-PAH before the development of high pulmonary vascular resistance and the establishment of fixed PAH.