THE GALACTOSE TOLERANCE TEST IN JAUNDICE; A CONSIDERATION OF THE EVIDENCE PERMITTING THE MEASUREMENT OF GALACTOSE UTILIZATION BY URINARY EXCRETION; SOME SOURCES FOR ERROR IN ITS INTERPRETATION; AND AN ADDITION IN ROUTINE TECHNIC
Authors: Harry Shay, Philip Fieman
Journal: Annals of Internal Medicine (1937)

Article1 March 1937THE GALACTOSE TOLERANCE TEST IN JAUNDICE; A CONSIDERATION OF THE EVIDENCE PERMITTING THE MEASUREMENT OF GALACTOSE UTILIZATION BY URINARY EXCRETION; SOME SOURCES FOR ERROR IN ITS INTERPRETATION; AND AN ADDITION IN ROUTINE TECHNICHARRY SHAY, M.D., PHILIP FIEMAN, M.D.HARRY SHAY, M.D.Search for more papers by this author, PHILIP FIEMAN, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-10-9-1297 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptIn 1931, in a paper on the study of the metabolism of galactose in the human subject, Shay, Schloss and Bell1concluded that this hexose was best suited for testing the carbohydrate function of the liver. In order for the urinary excretion of this sugar, orally administered, to act as a measure of hepatic carbohydrate function, they considered the following among the necessary conditions: (1) that there be no renal threshold for the excretion of galactose; (2) that galactose utilization remain unmodified by the activity of those endocrine glands known to affect glucose metabolism; (3) that galactose be practically unutilizable...Bibliography1. SHAYSCHLOSSBELL HEMMA: The metabolism of galactose. I. Considerations underlying the use of galactose in tests of the function of the liver, Arch. Int. Med., 1931, xlvii, 391-402. CrossrefGoogle Scholar2. ROESCHWARTZMAN JHAS: Galactose tolerance as a measure of liver function, Am. Jr. Med. Sci., 1933, clxxxvi, 425. CrossrefGoogle Scholar3. HARDINGGRANT VJGA: Metabolism of galactose. I. Cutaneous blood sugars after galactose ingestion, Jr. Biol. Chem., 1933, xcix, 629. CrossrefGoogle Scholar4. HARDINGVAN NOSTRAND VJFH: Variations in blood and urinary sugar after the ingestion of galactose, Jr. Biol. Chem., 1930, lxxxv, 765. CrossrefGoogle Scholar5. ROESCHWARTZMAN JHAS: Galactose tolerance of normal and diabetic subjects, and the effect of insulin upon galactose metabolism, Jr. Biol. Chem., 1932, xcvi, 717. CrossrefGoogle Scholar6. OWEN RK: The use of galactose in the differential diagnosis of jaundice, Jr. Lab. and Clin. Med., 1934, xix, 1311. Google Scholar7. FOLINBERGLUND OH: Some new observations and interpretations with reference to transportation, retention, and excretion of carbohydrates, Jr. Biol. Chem., 1922, li, 213. CrossrefGoogle Scholar8. GOLDBLATT MW: Observations on the effect of various carbohydrates on the ketosis of starvation in human subjects, Biochem. Jr., 1925, xix, 948. CrossrefGoogle Scholar9. MANNMAGATH FCTB: The effect of the administration of glucose in the condition following the total extirpation of the liver, Arch. Int. Med., 1922, xxx, 171. CrossrefGoogle Scholar10. WIERZUCHOWSKI M: Intermediärer Kohlenhydratstoffwechsel. IX. Intravenöse Galaktose-assimilation unter dem Einfluss der Hormone, des Hungers und der Nahrungsfaktoren, Biochem. Ztschr., 1931, cccxxvii, 92. Google Scholar11. ARCQ J: A propos de la fixation du galactose, Rev. Belge des Sci. Méd., 1931, iii, 860. Google Scholar12. LAQUERMEYER FP: Über den Abbau der Kohlehydrate im quergestreiften Muskel, Hoppe-Seyler's Ztschr. f. physiol. Chem., 1923, cxxiv, 211. CrossrefGoogle Scholar13. GRIESBACH W: Über die Verwertung einiger Zucker im Muskel, Ztschr. f. exper. Med., 1929, lxv, 172. CrossrefGoogle Scholar14. ROECOWGILL JHGR: The metabolic fate of galactose in adult dogs and rabbits, Am. Jr. Physiol., 1935, cxi, 530. CrossrefGoogle Scholar15. BOLLMANPOWERMANN JLMHFC: The relation of the liver to the metabolism of galactose, Proc. Staff Meet. Mayo Clin., 1931, vi, 724. Google Scholar16. BOLLMANMANNPOWER JLFCMH: The utilization of galactose following complete removal of the liver, Am. Jr. Physiol., 1935, cxi, 483. CrossrefGoogle Scholar17. ROEGILMANCOWGILL JHAGR: A study of the oxidation that occurs in the dog after the ingestion of galactose, Am. Jr. Physiol., 1934-35, cx, 531. CrossrefGoogle Scholar18. SHERIFHOLMES MAEG: A note on the oxygen consumption of nerve in presence of glucose and galactose, Biochem. Jr., 1930, xxiv, 400. CrossrefGoogle Scholar19. KOSTERLITZWEDLER HHW: Untersuchungen über die Verwertung der Galaktose in physiologischen und pathologischen Zuständen. II. Die Verwertung der Galaktose beim Diabetes mellitus. Die Galaktose als Ersatzkohlehydrat, Ztschr. f. d. ges. Exper. Med., 1933, lxxxvii, 397. CrossrefGoogle Scholar20. KOSTERLITZWEDLER HHW: III. Das Verhalten der Galaktose am pankreaslosen Hund bei völliger und teilweiser Insulinkarenz, Ztschr. f. d. ges. Exper. Med., 1933, lxxxvii, 405. CrossrefGoogle Scholar21. BOLLMANMANN JLFC: Utilization of various carbohydrates by the depancreatized animal, Am. Jr. Physiol., 1934, cvii, 183. Google Scholar22. SHAYSCHLOSSRODIS HEMI: The galactose tolerance test in the differential diagnosis of jaundice, Arch. Int. Med., 1931, xlvii, 650. CrossrefGoogle Scholar23. SHAYSCHLOSS HEM: Painless jaundice. Its differential diagnosis by the galactose tolerance test, Jr. Am. Med. Assoc., 1932, xcviii, 1433. CrossrefGoogle Scholar24. SCHIFFSENIOR LFA: A study of 100 cases of jaundice with particular reference to galactose tolerance, Jr. Am. Med. Assoc., 1934, ciii, 1924. CrossrefGoogle Scholar25. ROSENBERG DH: The galactose and urobilinogen test in the differential diagnosis of obstructive and intrahepatic jaundice, ANN. INT. MED., 1934, viii, 60. Google Scholar26. TUMENPIERSOL HJGM: The value of alimentary galactosuria in the diagnosis of jaundice, ANN. INT. MED., 1933, vii, 311. Google Scholar27. BLANCO JG: Sugar metabolism; lactose, galactose, and xylose, Jr. Biol. Chem., 1928, lxxix, 667. CrossrefGoogle Scholar28. BLOCKWEISZ JM: Reflex-oder Resorptionshyperglykämie? Ztschr. f. d. ges. Exper. Med., 1930, lxix, 453. CrossrefGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Philadelphia, Pennsylvania*Received for publication December 11, 1936.From the Gastro-Intestinal Division of Medical Service 1, Mt. Sinai Hospital, Philadelphia. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byIntravenous galactose tolerance test using a modified techniqueAN INTRAVENOUS GALACTOSE-TOLERANCE TESTThe Value Of A Combined Study Of The Newer Laboratory Test In The Differential Diagnosis Of Toxic And Obstructive Jaundice Including Blood Phosphatase, Cholesterol Partition, Galactose Tolerance And Glucose Tolerance 1 March 1937Volume 10, Issue 9Page: 1297-1303KeywordsCarbohydrate metabolismCarbohydratesEndocrine physiologyExcretionGastroenterology and hepatologyGlucose metabolismLiverMedical services ePublished: 1 December 2008 Issue Published: 1 March 1937 PDF downloadLoading ...