tbuckley/cabot-search huggingface dataset:
CONSIDERATIONS OF RENAL, HEPATIC, AND EXTREMITAL ARTERIOVENOUS DIFFERENCES IN CONCENTRATION OF RADIOMERCURY OF A MERCURIAL DIURETIC 1
Authors: Pervis Milnor, George Burch, Thorpe Ray, Sam Threefoot, Gerald Berenson
Journal: Journal of Clinical Investigation (1950)

Mercurial diuretics are employed extensively today in the management of congestive heart failure, but the mechanism by which elimination of electrolytes and water is increased is not thor- oughly understood.Furthermore, the metabolism and pharmacodynamics of mercury are only par- tially known despite the numerous investigations into the diuretic action of mercury.The majority of these studies have been concerned principally with clinical observations on the comparative value of various mercurial preparations, time of onset and quantity of diuresis, efficacy of the prepara- tion in the management of edematous states and toxicity.The anatomic changes in the kidney appearing as a reaction to mercury have been ade- quately studied, but the physiologic renal changes are not so well understood.The effects of mer- curial diuretics on electrolytes, especially chlorine, sodium, and potassium, have received considerable attention, as have the influence of the acidic salts and theophylline in enhancing diuresis.A few investigations have been conducted on the action of mercury on glomerular filtration and tubular reabsorption as well as on the distribution and ex- cretion of mercury.Experiments in animals have demonstrated limited ability of the kidney to re- move mercury from the blood when the element is administered in small amounts into the renal ar- tery.Studies of mercurial clearance, only recently possible in man, have not previously been reported.For purposes of clarifying certain aspects of these problems a mercurial diuretic (Mercuhy-
Systemic autoimmune disease arises from polyclonal B cell activation.
Authors: D M Klinman, A D Steinberg
Journal: The Journal of Experimental Medicine (1987)

The number of B cells producing antibodies reactive with any of seven autoantigens or two conventional antigens was compared at the single-cell level to the total number of Ig-secreting B cells present in the spleens of NZB, MRL lpr/lpr, and BXSB autoimmune mice. The proportion of lymphocytes producing antibodies of each specificity, expressed as a percentage of the total B cell repertoire, was virtually identical among autoimmune and congenic nonautoimmune animals. Furthermore, B cells and serum antibodies reactive with conventional antigens increased commensurately with those reactive with autoantigens. These results indicate that systemic autoimmune diseases arise from polyclonal B cell activation.
1183 Clinical evaluation of a new enzyme immunoassay for hepatitis B virus core-related antigen; a marker distinct from viral DNA for monitoring lamivudine treatment
Authors: A ROKUHARA, T KIMURA, A MATSUMOTO, E TANAKA, N MAKI, K KIYOSAWA
Journal: Hepatology (2003)

The objective of this study was to evaluate the validities of serum hepatitis B core-related antigen (HBcrAg) for predicting the pathological status of liver tissues of chronic hepatitis B (CHB). A total of 205 Chinese patients with CHB, including 121 HBeAg-positive and 84 HBeAg-negative patients, were enrolled in this study. In HBeAg-positive patients, AUCs of serum HBcrAg for predicting severe necro-inflammation and advanced fibrosis were greater than 0.70; using serum HBcrAg < = 4.81 × 104 kU mL−1 and < = 2.45 × 104 kU mL−1 as cutoffs, the sensitivities, specificities, accuracies for predicting severe necro-inflammation and advanced fbrosis were 0.697, 0.716, 0.711 and 0.818, 0.778, 0.785, respectively. In HBeAg-negative patients, the AUCs of serum HBcrAg for predicting significant necro-inflammation and significant fibrosis were greater than 0.70; using serum HBcrAg > = 1.70 × 102 kU mL−1 and > = 4.02 kU mL−1 as cutoffs, the sensitivities, specificities, accuracies for predicting significant necro-inflammation and significant fibrosis were 0.929, 0.964, 0.952 and 1.000, 1.000, 1.000, respectively. These results indicated favorable performances of serum HBcrAg for predicting severe necro-inflammation and advanced fibrosis in HBeAg-positive patients and significant necro-inflammation and significant fibrosis in negative patients.
Abstract 3739: Clinicopathologic significance of ERCC1, Thymidylate Synthase and Glutathione S-Transferase P1 expression for advanced gastric cancer patients receiving adjuvant 5-FU and cisplatin chemotherapy
Authors: SUNG YONG OH, Ki Han Kim, Sung Hyun Kim, Suee Lee, Kyung-A Kwon, Jin Seok Jang, Min Chan Kim, Su-Jin Kim, Hyo-Jin Kim, Hyuk-Chan Kwon
Journal: Cancer Research (2010)

Abstract Background: The aim of this study was to determine whether expressions of the excision cross-complementing (ERCC1), thymidylate synthase (TS) and glutathione S-transferase P1 (GSTP1) predict clinical outcome in patients with advanced gastric cancer treated with adjuvant 5-fluorouracil (5-FU) and cisplatin (FP) chemotherapy. Patients and methods: The study population consisted of 149 advanced gastric cancer patients. After curative resection, if the patients had stage II or higher disease, we administered adjuvant FP combination chemotherapy. The FP regimen was as follows. Cisplatin 60 mg/m2 was administered intravenously on day 1, and 5-FU 1,000 mg/m2 was administered intravenously on days 1 to 5. This regimen was repeated every three weeks. The expressions of ERCC1, TS and GSTP1 of primary tumors were examined by immunohistochemistry. Clinicopathologic information, including tumor size, histological grade, Lauren's classification, Borrmann type, vascular invasion, ratio of involved lymph nodes to dissected nodes, stage, carcinoembryonic antigen (CEA), and disease-free survival (DFS) and overall survival (OS) were evaluated with respect to the expressions of ERCC1, TS and GSTP1. Results: Median follow-up duration was 65.2 months, and median patient age was 51 ± 11 years (range 24-75). The positive rates of ERCC1, TS, and GSTP1 were 63.1%, 76.5%, and 40.3%, respectively. ERCC1 and GSTP1 expression was significantly correlated with size (p = 0.040, p = 0.018, respectively). Positive relationships were found between the expression of TS and Borrmann type (p = 0.030) and stage (p = 0.041). Univariate analysis showed that Lauren classification, stage, positive lymph node ratio, and type of operation were associated with both DFS and OS. ERCC1 and GTP1 were significant variables affecting OS (p = 0.005, p = 0.024, respectively). Patients who were both ERCC1 and GSTP1 positive had longer survival (p = 0.003). Multivariate analysis revealed that stage and positive lymph node ratio were independently associated with DFS and OS. Expression of both ERCC1 and GSTP1significantly impacted on OS (hazard ratio = 0.069, p = 0.021). Conclusion: Immunohistochemical studies for ERCC1 and GSTP1 were useful in prediction of the clinical outcome in advanced gastric cancer patients treated with adjuvant FP. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 101st Annual Meeting of the American Association for Cancer Research; 2010 Apr 17-21; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2010;70(8 Suppl):Abstract nr 3739.
Suppression of immune response by antigen-modified liposomes encapsulating model agents: A novel strategy for the treatment of allergy
Authors: Kanae Ichikawa, Tomohiro Asai, Kosuke Shimizu, Sei Yonezawa, Takeo Urakami, Haruna Miyauchi, Hiroto Kawashima, Tatsuhiro Ishida, Hiroshi Kiwada, Naoto Oku
Journal: Journal of Controlled Release (2013)
A coding VKORC1 Asp36Tyr polymorphism predisposes to warfarin resistance
Authors: Ronen Loebstein, Ilana Dvoskin, Hillel Halkin, Manuela Vecsler, Aharon Lubetsky, Gideon Rechavi, Ninette Amariglio, Yoram Cohen, Gie Ken-Dror, Shlomo Almog, Eva Gak
Journal: Blood (2006)
Coronary perfusion related changes in myocardial contractile force and systolic ventricular stiffness
Authors: T. Iwamoto, X.-J. Bai, H F. Downey
Journal: Cardiovascular Research (1994)

Journal Article Coronary perfusion related changes in myocardial contractile force and systolic ventricular stiffness Get access Toshihiro Iwamoto, Toshihiro Iwamoto Department of Physiology, University of North Texas Health Science Center at Fort Worth, 3500 Camp Bowie Boulevard, Fort Worth, TX 76107-2699, USA: T Iwamoto, X-J Bai, H F Downey. Correspondence to Dr Downey. Search for other works by this author on: Oxford Academic PubMed Google Scholar Xiao-Juan Bai, Xiao-Juan Bai Department of Physiology, University of North Texas Health Science Center at Fort Worth, 3500 Camp Bowie Boulevard, Fort Worth, TX 76107-2699, USA: T Iwamoto, X-J Bai, H F Downey. Search for other works by this author on: Oxford Academic PubMed Google Scholar H Fred Downey H Fred Downey Department of Physiology, University of North Texas Health Science Center at Fort Worth, 3500 Camp Bowie Boulevard, Fort Worth, TX 76107-2699, USA: T Iwamoto, X-J Bai, H F Downey. Search for other works by this author on: Oxford Academic PubMed Google Scholar Cardiovascular Research, Volume 28, Issue 9, September 1994, Pages 1331–1336, https://doi.org/10.1093/cvr/28.9.1331 Published: 01 September 1994 Article history Received: 23 December 1993 Accepted: 20 April 1994 Published: 01 September 1994
Schizophrenia and the Brain
Authors: M.-Marsel Mesulam
Journal: New England Journal of Medicine (1990)

Schizophrenia is a devastating disease of unknown cause. Its protean symptoms range from a pervasive blunting of affect, thought, and socialization, to florid hallucinations and delusions. Its characteristic onset during adolescence and young adulthood interferes with the most productive period of life and results in prolonged suffering. Even with the most up-to-date management, about half the patients have chronic deterioration, and the rest a more episodic course. The worldwide prevalence is approximately 1 percent. In the United States alone, the cost to society runs from $10 to $20 billion yearly.1 There have been two major advances in this field recently. . . .
Frequent somatic reversion of KRT1 mutations in ichthyosis with confetti
Authors: Keith A. Choate, Yin Lu, Jing Zhou, Peter M. Elias, Samir Zaidi, Amy S. Paller, Anita Farhi, Carol Nelson-Williams, Debra Crumrine, Leonard M. Milstone, Richard P. Lifton
Journal: Journal of Clinical Investigation (2015)

Widespread reversion of genetic disease is rare; however, such events are particularly evident in some skin disorders in which normal clones develop on a background of affected skin. We previously demonstrated that mutations in keratin 10 (KRT10) cause ichthyosis with confetti (IWC), a severe dominant disorder that is characterized by progressive development of hundreds of normal skin spots via revertant mosaicism. Here, we report on a clinical and histological IWC subtype in which affected subjects have red, scaly skin at birth, experience worsening palmoplantar keratoderma in childhood, and develop hundreds of normal skin spots, beginning at around 20 years of age, that increase in size and number over time. We identified a causal de novo mutation in keratin 1 (KRT1). Similar to IWC-causing KRT10 mutations, this mutation in KRT1 resulted in a C-terminal frameshift, replacing 22 C-terminal amino acids with an alternate 30-residue peptide. Mutant KRT1 caused partial collapse of the cytoplasmic intermediate filament network and mislocalized to the nucleus. As with KRT10 mutations causing IWC, reversion of KRT1 mutations occurred via mitotic recombination. Because reversion is not observed with other disease-causing keratin mutations, the results of this study implicate KRT1 and KRT10 C-terminal frameshift mutations in the high frequency of revertant mosaicism in IWC.
Syndrome of Left Ventricular-Right Atrial Shunt Resulting from High Interventricular Septal Defect Associated with Defective Septal Leaflet of the Tricuspid Valve
Authors: MILDRED STAHLMAN, SAMUEL KAPLAN, JAMES A. HELMSWORTH, LELAND C. CLARK, H. WILLIAM SCOTT
Journal: Circulation (1955)

Two similar cases of unusual congenital anomalies of the heart are presented, in which there existed a direct communication between the left ventricle and the right auricle through a defect involving the membranous portion of the interventricular septum with defective formation of the medial leaflet of the tricuspid valve. Data obtained at catheterization, operative and postmortem findings are presented in each case. The differential diagnosis of this type of lesion is discussed.
Response to Letter Regarding Article, “Searching for the Culprit Vessel in Acute Myocardial Infarction Beyond Angiography: Role of Cardiac Magnetic Resonance”
Authors: Eduardo Pozo, Irene Méndez, Amparo Benedicto, María José Olivera, Alfonso Ascensión, Luis Jesús Jiménez-Borreguero, Fernando Alfonso
Journal: Circulation (2015)
850-2 Value of signal-averaged ECG and electrophysiological testing in identifying arrhythmogenic right ventricle dysplasia patients who do receive implantable cardioverter defibrillator therapy
Authors: Khurram Nasir, Darshan Dalal, Chandra Bomma, HariKrishna Tandri, Daniyal Ahmed, Ariel Roguin, Crystal Tichnell, Cynthia James, Hugh Calkins
Journal: Journal of the American College of Cardiology (2004)
Sprue-like Mouth and Swelling of Lips as a Manifestation of Streptomycin Sensitivity
Authors: A. W. S. Thevathasan
Journal: BMJ (1949)

~~~fifth m e t a t a r s o- phalangeal joints, with the little toe directed in s, following the axial deviation of the outer three digits.Radiographs show a varus position of the little toe, adaptive changes in the basal phalangeal and metatarsal epiphyses, and outward splaying of the fifth metatarsal.Clinically and radio- logically the condition therefore resembles metatarsus p r i m u s varus.
A New Endoscopic Method for Managing Food Impaction in the Esophagus
Authors: Z. A. Saeed, P. A. Michaletz, S. D. Feiner, K. L. Woods, D. Y. Graham
Journal: Endoscopy (1990)

Previously described methods for dealing with acute food impaction in the esophagus are not uniformly efficacious, are cumbersome, and often prove dangerous. This paper describes a new technique using an endoscope which is modified such that the endoscope itself becomes a direct-vision suction device. We have successfully used the technique in seven patients with meat bolus impaction in the esophagus. The method proved quick and safe, and no complications occurred. After relieving the impaction an adequate diagnostic examination was done in all patients. In four patients with a predisposing peptic stricture and one with Schatzki's ring, treatment of the lesion was possible during the same endoscopic session.
The integrity of the ether linkage during thyroxine metabolism in man
Authors: Constance S. Pittman, Virginia H. Read, Joseph B. Chambers, Haruyoshi Nakafuji
Journal: Journal of Clinical Investigation (1970)

The structures of thyroxine metabolites after total deiodination bear on the mode of thyroxine (T4) action in vivo. The present study was undertaken to determine the integrity of the ether linkage during thyroxine metabolism in man. Normal volunteers were given simultaneous intravenous injections of two thyroxines labeled with either 14C or 3H on the opposite sides of the ether linkage, D,L-[α,β-3H]T4 and D,L-[phenolic ring-14C]T4. The ratio of alanine side chain to phenolic ring which was measured as 3H:14C ratio was found to remain constant in the serum, urine, and feces during the subsequent 3 wk. The disappearance rates of the 3H and 14C radioactivity from blood were similar. The values of half-life were in the ranges of 4.2-6.7 days. 51-63% of the 3H and 50-57% of the 14C doses were recovered from urine and 13-20% of the 3H and 15-20% of the 14C doses were recovered from feces. Chromatography of the urinary metabolites confirmed that the phenolic ring and the nonphenolic ring including at least part of the side chain remained linked together.
Phakomatosis pigmentovascularis type IIb associated with Klippel–Trénaunay syndrome and congenital triangular alopecia
Authors: Bengu Gerceker Turk, Meltem Turkmen, Arzu Tuna, Isil Kilinc Karaarslan, Fezal Ozdemir
Journal: Journal of the American Academy of Dermatology (2011)
P809 PATIENTS WITH T2DM ACCOMPANYING SEVERE DEGREE OF NAFLD ASSESSED BY CONTROLLED ATTENUATION PARAMETER USING FIBROSCAN
Authors: Y.E. Chon, K. Kim, K.S. Jung, S.U. Kim, J.Y. Park, D.Y. Kim, S.H. Ahn, C.Y. Chon, K.-H. Han
Journal: Journal of Hepatology (2014)
Toward Better Integration of Medical and Psychiatric Care
Authors: Mark L. Teitelbaum
Journal: JAMA (1982)

The article by Dr Hoffman in this issue ofThe Journal(p 964) is timely and important. Efforts to integrate medical and psychiatric care of patients such as described underscore how poorly medical and psychiatric care of patients is sometimes integrated. This lack of integration persists despite the awareness, since ancient times, of the association between physical and psychological disturbance and, more recently, epidemiologic work that clearly demonstrates this association.<sup>1</sup>It has been estimated that of the 15% of the population of the United States that is psychiatrically ill and in need of mental health services, approximately 60% are seen in the general health care setting.<sup>2</sup>Epidemiologic surveys report the prevalence of psychiatric disorder to be anywhere from 30% to 60% among medical inpatients and from 50% to 80% among medical outpatients.<sup>3</sup>Studies conducted at The Johns Hopkins Hospital have shown that anywhere from 29% to 37%
Generalized Decreased Osseous Uptake on Bone Scintigraphy in Hepatorenal Syndrome
Authors: Henrik Gutte, Liselotte H??jgaard
Journal: Clinical Nuclear Medicine (2005)

A 52-year-old Caucasian male with a history of heavy alcohol abuse and liver cirrhosis was admitted with hepatorenal syndrome, consistent bacteraemia (enterococcus faecalis in blood culture) and low back pain. A bone scan revealed generalized decreased osseous uptake, increased uptake in the spine, several foci in the ribs, and diffuse bilateral increased renal uptake.
Screening of novel genetic aberrations in pediatric acute myeloid leukemia: a report from the AIEOP AML-2002 study group
Authors: Martina Pigazzi, Elena Manara, Valeria Bisio, Sanja Aveic, Riccardo Masetti, Giuseppe Menna, Marco Zecca, Andrea Pession, Franco Locatelli, Giuseppe Basso
Journal: Blood (2012)
Adjuvant Mitotane Therapy of Adrenal Cancer — Use and Controversy
Authors: David E. Schteingart
Journal: New England Journal of Medicine (2007)

Adrenocortical carcinoma is a rare, highly malignant neoplasm with an incidence of 2 cases per 1 million population per year worldwide, representing 0.2% of all cases of cancer. Several treatment strategies in patients with advanced disease have resulted in temporary or partial tumor regression, yet very few patients attain long-term survival. Assessing the effectiveness of most published treatment protocols has been difficult, since most series have been limited by the inclusion of relatively few subjects, with tumors at various stages and grades. Several drug regimens have been used, and multiple treatments have been administered in various sequences. In addition, the . . .
European legislators tighten rules on drug safety
Authors: R. Watson
Journal: BMJ (2012)

The European Union has agreed major changes to new pharmacovigilance legislation, which came into force this July, to strengthen monitoring procedures used across the continent to ensure the safety of drugs.

The trigger for the latest package of amendments, which was endorsed by the European parliament on 11 September, was the drug safety inquiry launched in France last year (after the EU legislation had been agreed in December 2010) into the drug Mediator.1 Produced by the French company Servier, its main active ingredient was benfluorex to treat type 2 diabetes.

Despite the emergence of adverse reaction reports …
552. Gene Therapy of Uterine Fibroids: Adenovirus-Mediated Expression of Dominant Negative Estrogen Receptor Inhibits ERE-Reporter Transactivation in Rat and Human Leiomyoma Cells.
Authors: Ayman Al-Hendy
Journal: Molecular Therapy (2005)

Introduction: Uterine leiomyomas (fibroids) are the most common tumors in premenopausal women. Currently there is no medicinal treatment for this condition and surgery is the main stay. This constitutes a clinical dilemma especially in young fibroid patients who desire to preserve their fertility. We have recently (Am J Obstetrics and Gynecology, 2004,191:00-00) demonstrated the ability of a mutated dominant-negative estrogen receptor gene delivered via an adenoviral vector (Ad-DN-ER) to induce apoptosis in leiomyoma cells as well as ablate pre-existing fibroids in vivo.
Severe acute respiratory syndrome: Guidelines were drawn up collaboratively to protect healthcare workers in British Columbia
Authors: A. Yassi
Journal: BMJ (2003)

<h3>Objectives</h3> National dietary guidelines were introduced in 1977 and 1983, by the US and UK governments, respectively, with the ambition of reducing coronary heart disease (CHD) by reducing fat intake. To date, no analysis of the evidence base for these recommendations has been undertaken. The present study examines the evidence from randomised controlled trials (RCTs) available to the US and UK regulatory committees at their respective points of implementation. <h3>Methods</h3> A systematic review and meta-analysis were undertaken of RCTs, published prior to 1983, which examined the relationship between dietary fat, serum cholesterol and the development of CHD. <h3>Results</h3> 2467 males participated in six dietary trials: five secondary prevention studies and one including healthy participants. There were 370 deaths from all-cause mortality in the intervention and control groups. The risk ratio (RR) from meta-analysis was 0.996 (95% CI 0.865 to 1.147). There were 207 and 216 deaths from CHD in the intervention and control groups, respectively. The RR was 0.989 (95% CI 0.784 to 1.247). There were no differences in all-cause mortality and non-significant differences in CHD mortality, resulting from the dietary interventions. The reductions in mean serum cholesterol levels were significantly higher in the intervention groups; this did not result in significant differences in CHD or all-cause mortality. Government dietary fat recommendations were untested in any trial prior to being introduced. <h3>Conclusions</h3> Dietary recommendations were introduced for 220 million US and 56 million UK citizens by 1983, in the absence of supporting evidence from RCTs.
Fundholders' patients are treated quicker, says BMA
Authors: L Beecham
Journal: BMJ (1994)

Over 40% of respondents in a survey by the British Medical Association said that patients of general practitioner fundholders were being treated more quickly than other patients in their hospitals. Last October the Central Consultants and Specialists Committee (CCSC) sent out a questionnaire to 247 short stay units in England; 173 replied. Of these, 73 units (42%) said that arrangements were offered to fundholders' patients that were …