tbuckley/cabot-search huggingface dataset:
THE AMERICAN MEDICAL ASSOCIATION, ITS AIMS AND INTERESTS.PRESIDENT'S ADDRESS AT THE FIFTY-EIGHTH ANNUAL SESSION OF THE AMERICAN MEDICAL ASSOCIATION AT ATLANTIC CITY, N. J., JUNE 4-7, 1907.
Authors: JOSEPH D. BRYANT
Journal: JAMA (1907)

The fifty-eighth consecutive session of the American Medical Association is now at hand. Those members whom you kindly honored one year ago with your confidence in official station are now before you in token of their loyalty to your undertakings and of their obedience to your behests. These annual conferences are of prodigious moment to the entire medical profession and to the country at large; they serve to broaden the scope of general understanding; they extend the sphere and increase the vigor of professional fellowship and of healthy civic brotherhood, and they correspondingly elevate the station of our calling in the appreciation of thoughtful right-minded people everywhere in the land. Who of us was not made a better physician because of the visit to Boston a year ago? Who of us, then inspired by patriotic emotions, aroused by the memorable examples so abundantly at hand, did not again renew unalterable
Assessment of QT Interval and QT Dispersion for Prediction of All-Cause and Cardiovascular Mortality in American Indians
Authors: Peter M. Okin, Richard B. Devereux, Barbara V. Howard, Richard R. Fabsitz, Elisa T. Lee, Thomas K. Welty
Journal: Circulation (2000)

Background —Both a prolonged QT interval and increased QT interval dispersion (QTD) have been proposed as surface ECG markers of vulnerability to ventricular arrhythmias and potential predictors of mortality. Methods and Results —The predictive values of QT prolongation and QTD were assessed in 1839 participants in the Strong Heart Study, a prospective study of cardiovascular disease in American Indians. ECGs were acquired at 250 Hz; QT intervals were measured by computer in all 12 leads and corrected for heart rate (QTc) by use of Bazett’s formula. QTD was calculated as the difference between the maximum and minimum QTc. After a mean follow-up of 3.7±0.9 years, there were 188 deaths from all causes, including 55 cardiovascular deaths. In univariate Cox analyses, prolonged QTc and increased QTD were significant predictors of all-cause mortality (χ 2 =53.0, P &lt;0.0001; χ 2 =11.3, P =0.0008) and cardiovascular mortality (χ 2 =14.7, P =0.0001; χ 2 =26.5, P &lt;0.0001). In multivariate Cox regression analyses controlling for risk factors, QTc remained a strong predictor of all-cause mortality (χ 2 =16.5, P &lt;0.0001) and a weaker predictor of cardiovascular mortality (χ 2 =5.8, P =0.016); QTD remained a significant predictor of cardiovascular mortality only (χ 2 =12.5, P =0.0004). Conclusions —These findings support the value of computerized measurements of QTc and QTD in noninvasive risk stratification and suggest that these surface ECG variables may reflect different underlying abnormalities of ventricular repolarization.
Review of international drugs policies is unlikely to change UK stance on criminality
Authors: Z. Kmietowicz
Journal: BMJ (2014)

A study of how other countries approach drug misuse and addiction is unlikely to lead to any change in drug policy in the United Kingdom, despite the study’s finding that tougher criminal sentences for drug misuse did not reduce levels of use, the government has said.

The study was commissioned by the coalition government to appease MPs on the Home Affairs Select Committee, who in a 2012 report called for a royal commission to rethink the UK approach to drugs. Evidence for the study was gathered from 11 countries that have introduced various approaches to try to reduce the effects of drug misuse on society, the judicial system, and health.1

The study dismissed most of the approaches it observed as being inappropriate for the UK or incompatible …
751 AVL-192: POTENCY AGAINST HCV NS3 MUTANTS ALLOWS FOR REPLICON CLEARANCE AS A MONOTHERAPY AND IN COMBINATION STUDIES
Authors: M. Hagel, D. Niu, T. St. Martin, M. Sheets, L. Qiao, P. Chaturvedi, M. Labenski, M. Nacht, R. Petter, J. Singh, W. Westlin
Journal: Journal of Hepatology (2010)
The Role of Testing for<i>BRCA1</i>and<i>BRCA2</i>Mutations in Cancer Prevention
Authors: Anne Marie McCarthy, Katrina Armstrong
Journal: JAMA Internal Medicine (2014)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Internal Medicine HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Internal Medicine journal
Learning Disabilities and Brain Function: A Neuropsychological Approach
Authors: David L. Coulter
Journal: JAMA (1981)

This ambitious book attempts to relate neurology and education by applying neuropsychology to childhood learning disorders. It is written primarily for teachers to promote the development of "neuroeducators," as William Cruickshank, PhD, argues in the foreword. In fact, an evangelical tone colors this attempt to "convert" teachers to a neuropsychological point of view. The first two introductory chapters are followed by an oversimplified and flawed exposition of neuroscience in relation to learning. Here, as elsewhere, the neurology is surprisingly naive (referring to dendrites as "dendrons" for example). The more important parts of the book are contained in six chapters that constitute a balanced review of neuropsychology. A chapter on therapy is followed by a summary chapter or "Postscript." "Clinical Addendums" at the end of most chapters and numerous case summaries scattered throughout the text help to relate the neuropsychological principles to actual clinical situations that a teacher might encounter. Gaddes
Legal Implications of Changing Patterns of Practice
Authors: Joseph F. Sadusk
Journal: JAMA (1964)

The complexity of modern medical care and, more directly, the shortage of highly trained personnel present a need for increased interdependence of nurse and physician. Whereas a poor delineation of duties between physician and nurse has emerged, a clearer delineation between the professional nurse and the practical nurse is evident. It seems likely, therefore, that some of the physician's present obligations to his patient will be passed to the professional nurse, who in turn will pass along some of her tasks to the practical nurse. Indeed, such changes are already taking place. For example, the professional nurse has transferred many of her traditional bedside-care duties to the practical nurse; and the physician has transmitted responsibility to the professional nurse for starting intravenous solutions. The legal implications of these changes in duties are important, as it is basic in the law that increased authority necessarily carries with it increased responsibility. This
Dystrophin-deficient myocardium is vulnerable to pressure overload in vivo
Authors: Y Kamogawa
Journal: Cardiovascular Research (2001)

Objective: Dystrophin provides mechanical reinforcement to the membranes of myocytes. Dystrophin abnormalities are known to cause cardiomyopathy and skeletal muscle disorders; however, the pathogenesis of these abnormalities remains unclear. Dystrophin-deficient skeletal muscle is vulnerable to stresses such as stretch and hypo-osmotic shock. We investigated whether the myocardium of dystrophin-deficient (mdx) mice shows increased vulnerability to acute pressure overload in vivo. Methods and results: Abdominal aortic banding was performed in 12-week-old mdx and control mice. The aortic pressure was measured by cannulation of the right carotid artery at the time of sacrifice. Systolic pressures in mdx mice at 0, 1, 2, 7 and 14 days after aortic banding were 100±11, 119±7, 123±4, 134±11 and 130±10 mmHg, respectively. Microscopic analysis revealed focal lesions in the left ventricular wall in banded mdx mice. These lesions consisted of damaged myocytes and inflammatory cells, and also of fibrosis at a late stage. Similar lesions were not observed in non-banded or banded control mice. The proportion of areas of lesions to total left ventricular area increased over time: 1.0±0.6% in mdx mice without aortic banding (sham, n=6), and 1.7±1.4% 1 day (n=6, vs. sham, NS), 2.6±1.9% 2 days (n=7, vs. sham, P<0.05), 6.3±6.5% 7 days (n=13, vs. sham, P<0.05) and 9.9±8.3% 14 days after aortic banding (n=15, vs. sham, P<0.01). Furthermore, linear regression analysis revealed a significant correlation between percentage of lesion area and systolic pressure in mdx mice (P<0.05). Conclusion: Dystrophin-deficient myocardium is more vulnerable than normal myocardium to pressure overload in vivo. This result has two clinical implications: (1) the patients with dystrophynopathy, such as the Duchenne and the Becker types of muscular dystrophy and X-linked type of dilated cardiomyopathy, who develop arterial hypertension should be treated aggressively, and (2) they should avoid stresses that elevate blood pressure.
STUDIES ON THE HETEROLOGOUS IMMUNOGENICITY OF A METHANOL-INSOLUBLE FRACTION OF ATTENUATED TUBERCLE BACILLI (BCG)
Authors: David W. Weiss, Rose S. Bonhag, James A. Parks
Journal: The Journal of Experimental Medicine (1964)

Small quantities of the non-toxic residue of phenol-killed, acetone-washed, and methanol-extracted tubercle bacilli of the BCG strain conferred a high degree of resistance on mice against otherwise lethal experimental infection with Klebsiella pneumoniae and with a number of other pathogenic bacteria. The heightened resistance reached a peak within 24 hours after administration of the fraction, but was already discernible immediately thereafter. A period of reduced resistance was not observed. The state of heightened resistance was invariably manifested for at least 10 days, and could frequently still be demonstrated after several weeks or months. The methanol-insoluble fraction was immunogenically active even in experimental circumstances under which living BCG exerted no effect. Its protective effect was more marked in females than in males. The optimum dosage must be determined empirically vis-á-vis the strain of infecting organisms and the experimental parameters of administration and testing. Administration of the fraction to breeding females reduced the incidence of a naturally occurring endemic pneumonitis among their young, and increased considerably the breeding productivity of the mothers. These effects were manifested as late as 11 months after treatment.
Phase-contrast magnetic resonance angiography: A new approach in the evaluation of coronary LAD artery graft patency and flow following treatment of LIMA hypoperfusion syndrome with additional vein graft
Authors: Gregor Zund, Markus Hauser, Paul Vogt, Jorg Debatin, Ludwig K. von Segesser, Marko Turina
Journal: Journal of the American College of Cardiology (1996)
Exome-wide association study identifies a TM6SF2 variant that confers susceptibility to nonalcoholic fatty liver disease
Authors: Julia Kozlitina, Eriks Smagris, Stefan Stender, Børge G Nordestgaard, Heather H Zhou, Anne Tybjærg-Hansen, Thomas F Vogt, Helen H Hobbs, Jonathan C Cohen
Journal: Nature Genetics (2014)
Structural requirements for binding of an immunodominant myelin basic protein peptide to DR2 isotypes and for its recognition by human T cell clones.
Authors: K W Wucherpfennig, A Sette, S Southwood, C Oseroff, M Matsui, J L Strominger, D A Hafler
Journal: The Journal of Experimental Medicine (1994)

Immunodominant T cell epitopes of myelin basic protein (MBP) may be target antigens for major histocompatibility complex class II-restricted, autoreactive T cells in multiple sclerosis (MS). Since susceptibility to MS is associated with the DR2 haplotype, the binding and presentation of the immunodominant MBP(84-102) peptide by DR2 antigens were examined. The immunodominant MBP(84-102) peptide was found to bind with high affinity to DRB1*1501 and DRB5*0101 molecules of the disease-associated DR2 haplotype. Overlapping but distinct peptide segments were critical for binding to these molecules; hydrophobic residues (Val189 and Phe92) in the MBP(88-95) segment were critical for peptide binding to DRB1*1501 molecules, whereas hydrophobic and charged residues (Phe92, Lys93) in the MBP(89-101/102) sequence contributed to DRB5*0101 binding. The different registers for peptide binding made different peptide side chains available for interaction with the T cell receptor. Although the peptide was bound with high affinity by both DRB1 and DRB5 molecules, only DRB1 (DRB1*1501 and 1602) but not DRB5 molecules served as restriction elements for a panel of T cell clones generated from two MS patients suggesting that the complex of MBP(84-102) and DRB1 molecules is more immunogenic for MBP reactive T cells. The minimal MBP peptide epitope for several T cell clones and the residues important for binding to DRB1*1501 molecules and for T cell stimulation have been defined.
Medicinema—Doctors in Films
Authors: Tony Miksanek
Journal: JAMA (2010)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Gene Silencing and Vasculitis
Authors: M. J. Friedrich
Journal: JAMA (2010)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Sexual Medicine in Primary Care
Authors: Sharon J. Parish, William H. Salazar
Journal: Annals of Internal Medicine (1999)

Medical Writings: Book Notes19 October 1999Sexual Medicine in Primary CareSharon J. Parish, MD and William H. Salazar, MDSharon J. Parish, MDAlbert Einstein College of Medicine, Bronx, New York (Parish)Medical College of Georgia, Augusta, Georgia. (Salazar)Search for more papers by this author and William H. Salazar, MDAlbert Einstein College of Medicine, Bronx, New York (Parish)Medical College of Georgia, Augusta, Georgia. (Salazar)Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-131-8-199910190-00036 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail Maurice WL. 366 pages. St. Louis: Mosby; 1999. $39.95. ISBN 0815127979. Order phone 800-426-4545.Field of medicine: Internal medicine, family medicine, psychiatry, and behavioral medicine.Format: Softcover book.Audience: Primary care providers, psychiatrists, gynecologists, and trainees.Purpose: To provide a comprehensive guide to taking a sexual history and evaluating and treating sexual dysfunctions encountered in primary care.Content: The first part of the book addresses taking a sexual history and emphasizes screening; clinician barriers; and developmental, life cycle, and sexual orientation issues. Sample dialogues demonstrate how and when to ask questions, which words to use, and what paths to follow ... Author, Article, and Disclosure InformationAffiliations: Albert Einstein College of Medicine, Bronx, New York (Parish)Medical College of Georgia, Augusta, Georgia. (Salazar) PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 19 October 1999Volume 131, Issue 8Page: 636KeywordsEmotionsFearHomosexualsHuman sexual behaviorInformation theorySexual and gender issuesSexual dysfunctionSexual identitySoftware tools ePublished: 15 August 2000 Issue Published: 19 October 1999 Copyright & PermissionsCopyright © 1999 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Medicine and the Media: Un-health promotion: results of a survey of alcohol promotion on television
Authors: R. Barton, S. Godfrey
Journal: BMJ (1988)

To estimate how widely and to whom alcoholic drinks are promoted 1258 television advertisements were studied over a 10 week period that included the Christmas and New Year holidays in 1986-7. A total of 156 advertisements (12%) promoted alcohol, and this percentage increased significantly over the holiday period to 17%. These advertisements were longer than those advertising other products, and just over half (56%) occupied the first position in commercial breaks. During sports programmes and between the hours of 1800 and 1900 there was an increase in the number of advertisements for alcohol, but there was no difference before and after 2100. It was found that the extent and influence of the promotion of alcohol were great and that such advertising is seen by many children and adolescents.
Prevention of oral food allergy sensitization via skin application of food allergen in a mouse model
Authors: W. Li, Z. Zhang, A. Saxon, K. Zhang
Journal: Allergy (2012)

Treatment options for food allergy remain limited. Development of novel approaches for the prevention and/or treatment of severe peanut allergy and other food allergies is urgently needed. The objective of this study was to test whether skin application of food allergen can be used as a prophylactic and/or therapeutic intervention for food allergy.Balb/C mice were given 5 weekly cutaneous application of complete peanut extract (CPE) or ovalbumin (OVA) ranging from 10 to 1000 μg on the shaved back skin, followed by 5 weekly treatments with oral CPE or OVA plus cholera toxin to induce allergic reactivity to the food. At various time points, the immunologic responses and allergic clinical manifestations to allergens were examined.Skin application of a 10-1000 μg dose of CPE or OVA to structurally intact skin did not lead to allergic sensitization to peanut or OVA. Rather, cutaneous allergen application blocked, in a dose-dependent fashion, the subsequent induction of the oral sensitization including inhibiting oral sensitization-induced CPE-specific IgE, IgG1, and IgG2a production, suppressing the peanut anaphylaxis, and modulating the oral sensitization-promoted cytokine production. The cutaneous OVA application also resulted in similar results as seen with CPE application.Cutaneous application of intact skin with peanut or OVA can block the development of orally induced corresponding food allergies, suggesting that allergic tolerance to peanuts and OVA might be achieved via allergen cutaneous application.
Retinoblastoma: Epidemiologic Characteristics
Authors: Robert D. Jensen, Robert W. Miller
Journal: New England Journal of Medicine (1971)

Nationwide study of 269 death certificates for United States children with retinoblastoma, 1960–67, revealed a peak in mortality at two to three years of age that was 2 1/2 times greater in Negroes than in whites. Nationally, an estimated 81 per cent of children with the neoplasm survived. Study of 1623 hospital records of children with retinoblastoma revealed an excess of mental retardation: 21 cases observed vs. 4.7 expected. Associated malformations in several cases suggested D-deletion syndrome, which has been described by others in six children with retinoblastoma. In accord with previous studies, radiotherapy was associated with an excess of osteosarcoma, soft-tissue neoplasms or carcinoma of the skin. In addition, 11 children had second primary cancers not attributable to radiotherapy, a seeming excess over normal expectation. The cell types were diverse, but three were osteosarcomas, suggesting an innate susceptibility that may add to the risk of radiotherapy.