THE METABOLISM OF FOLIC ACID IN CIRRHOSIS
Authors: J H JANDL, A A LEAR
Journal: Annals of Internal Medicine (1956)

Article1 December 1956THE METABOLISM OF FOLIC ACID IN CIRRHOSISJAMES H. JANDL, M.D., ARNOLD A. LEAR, M.D.JAMES H. JANDL, M.D., ARNOLD A. LEAR, M.D.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-45-6-1027 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe prevalence of macrocytic anemia in patients with chronic liver disease has suggested to many observers that liver damage disturbs hematopoiesis by altering the storage or the metabolism of one or more of the substances effective in the treatment of pernicious anemia.1-4However, it has been observed that most cases of the macrocytic anemia of liver disease bear little resemblance to pernicious anemia morphologically, and generally do not respond to liver extract.5, 6Moreover, extracts prepared from the livers of patients with the anemia of liver disease have been found to possess antipernicious anemia activity.7Nevertheless, apparent hematologic responses to...Bibliography1. 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Author, Article, and Disclosure InformationAffiliations: Boston, Massachusetts*Received for publication August 8, 1956.From the Thorndike Memorial Laboratory and Second and Fourth (Harvard) Medical Services, Boston City Hospital, and the Department of Medicine, Harvard Medical School, Boston, Massachusetts.This investigation was supported in part by the J. K. Lilly gift to the Harvard Medical School and by a grant from the Helen Hay Whitney Foundation.†Present address: 4314 Gallatin Street, Hyattsville, Maryland.Requests for reprints should be addressed to James H. Jandl, M.D., Thorndike Memorial Laboratory, Boston City Hospital, Boston 18, Massachusetts. 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DAVIDSON, M.D., F.A.C.P.The Diagnosis and Treatment of Folic Acid DeficiencyMegaloblastic anemia during pregnancy and the puerperiumMalabsorption Syndrome Associated with Anicteric Liver DiseaseMetabolic Effects and Diagnostic Value of Small Doses of Folic Acid and B12 in Megaloblastic Anemias1MEGALOBLASTIC ANlEMIA OF PREGNANCYMegaloblastic Anemia in Scurvy with Response to 50 Microgm. of Folic Acid DailyNutritional and other megaloblastic anaemias among Africans and Indians in DurbanThe Urinary and Faecal Excretion of Radioactivity after Oral Doses of 3 H-folk AcidErythrocyte dynamics in liver diseaseBone-Marrow Failure Due to Relative Nutritional Deficiency in Cooley's Hemolytic AnemiaThe Folic Acid Excretion Test in the Steatorrhea SyndromeNon-addisonian megaloblastic anemiaHemochromatosis with Megaloblastic Anemia Responding to Folic AcidSpontaneous Remission in Pernicious AnemiaTreatment of megaloblastic anemias 1 December 1956Volume 45, Issue 6Page: 1027-1044KeywordsAlcoholsAnemiaCirrhosisFolic acidHospital medicineLiverLiver diseasesOral administrationPernicious anemiaResearch laboratories Issue Published: 1 December 1956 PDF downloadLoading ...