tbuckley/cabot-search huggingface dataset:
Regression of Body Compositional Abnormalities of Heart Failure after Intracardiac Operations
Authors: ALBERT D. PACIFICO, STAN DIGERNESS, JOHN W. KIRKLIN
Journal: Circulation (1970)

Alterations in body composition are present in patients with heart disease and congestive heart failure, and additional changes occur acutely after corrective surgery. The reversibility and time course of reversion to normal body composition have not been demonstrated. Nine patients were studied preoperatively and 2 to 4 weeks and 6 to 12 mo postoperatively. Measurements were made, using the isotope-dilution technic, of the volumes of total body water, extracellular water, plasma, and red cells, and of the amounts of total exchangeable sodium and potassium. Values were derived for body fat, indices of body cell mass, and the intracellular and extracellular distribution of water and potassium. Significant changes ( P &lt; 0.05) occurring 2 to 4 weeks after operation were increased in total body water (8.2%), intracellular water (15.0%), exchangeable sodium (7.1%), and intracellular potassium content (7.7%), and decrease in body weight (4.6%) and body fat (21.6%); 6 to 12 mo postoperatively there was increase in exchangeable potassium (6.8%), body weight (7.8%), and decrease in exchangeable sodium (16.1%), extracellular fluid (7.8%), plasma (8.0%), and the ratio of exchangeable sodium to exchangeable potassium (23.6%). Late postoperative values were similar to predicted normal values and indicate that postoperative recovery from valvular replacement in these patients is accompanied by resolution of most of the body compositional abnormalities of heart failure.
Comparative study between cold air analgesia and supraorbital and supratrochlear nerve block for the management of pain during photodynamic therapy for actinic keratoses of the frontotemporal zone
Authors: C. Serra-Guillen, L. Hueso, E. Nagore, M. Vila, B. Llombart, C. Requena Caballero, R. Botella-Estrada, O. Sanmartin, A. Alfaro-Rubio, C. Guillen
Journal: British Journal of Dermatology (2009)

Background Photodynamic therapy (PDT) is an effective treatment for actinic keratoses, Bowen's disease and basal cell carcinoma. The main drawback of PDT is pain during application. Objectives To compare the efficacy of supratrochlear and supraorbital nerve block with cold air analgesia to control the pain experienced during PDT. Methods A controlled open clinical trial was conducted in 34 patients having multiple actinic keratoses in the frontal region treated with PDT. On one side of the frontal region the supratrochlear and supraorbital nerves were blocked, while on the other side cold air was used as the method of analgesia. Pain was recorded on a visual analogue scale after treatment. Results Thirty‐one of 34 patients reported less pain in the zone treated with nerve block. This difference was statistically significant. Conclusions Nerve block is superior to cold air and is an easy, safe, effective means of controlling the pain associated with PDT.
SOME PREPARATIONS OF THE NATIONAL FORMULARY.
Authors: C. LEWIS DIEHL
Journal: JAMA (1898)

At the meeting of thisAssociationin 1893 I had the honor to read a paper<sup>1</sup>before this Section, in which I outlined some of the conditions that have had marked influence upon the practice of pharmacy in its relation to that of medicine. I pointed out that the modern practice of prescribing medicaments of special manufacture had become a burden upon the pharmacist which, if not relieved, would surely end disastrously to those who, adhering to the ancient landmarks, strove to supply their patrons with medicaments of their own manufacture or of generally recognized and officially accepted composition. Indeed, the thought has impressed itself more and more upon my mind, that if physicians had entered into a conspiracy to drive the educated and qualified pharmacist out of business, they could not have pursued a more certain method than that which has become a common practice during the last
The cultivation of human multipotent mesenchymal stromal cells in clinical grade medium for bone tissue engineering
Authors: Robert Pytlík, David Stehlík, Tomáš Soukup, Marie Kalbáčová, František Rypáček, Tomáš Trč, Katarína Mulinková, Petra Michnová, Linda Kideryová, Jan Živný, Pavel Klener, Romana Veselá, Marek Trněný, Pavel Klener
Journal: Biomaterials (2009)
Case 21-1969
Authors: Paul H. Black, Harold F. Dvorak
Journal: New England Journal of Medicine (1969)

Presentation of CaseA sixty-eight-year-old man was admitted to the hospital because of hematemesis and melena.He had been well until two days previously, when there was the onset of repeated hematemesis. On the next day the stools became bloody.He had had no abdominal pain or previous episodes of nausea, vomiting or melena. He had imbibed alcohol in large amounts for many years but had abstained during the two years before entry. A cholecystectomy has been performed in the past. His weight had been stable.The patient was cold and clammy, with a thready pulse. The anteroposterior diameter of . . .
Hypertonic Peritoneal Dialysis
Authors: M.V. MORIARTY
Journal: Annals of Internal Medicine (1970)

Letters and Comments1 January 1970Hypertonic Peritoneal DialysisM.V. MORIARTY, M.B., F.R.C.P. (C.)M.V. MORIARTY, M.B., F.R.C.P. (C.)Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-72-1-146 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: Drs. Nolph, Hano, and Teschan are to be congratulated on their thorough exposition of the problems of water and solute transport during hypertonic peritoneal dialysis (May 1969 ANNALS). I would like to draw attention however to the fact that their main observations—"Hypertonic glucose exchanges invariably yielded an ultrafiltrate that was hyponatric to serum" and "The development of hypernatremia during hypertonic peritoneal dialysis results from proportionately greater removal of extra cellular water than sodium and not by the inward diffusion of sodium from the peritoneal dialysate"—have already been documented. The same remark applies to their equation deriving a...Reference1. Proc. E.D.T.A. III. 359, 1966. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Renal Unit The Vancouver General Hospital Vancouver 9, B.C. Canada PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByComplications of peritoneal dialysis other than peritonitisComplications of Peritoneal Dialysis Other Than PeritonitisFluid and Electrolyte Complications of Peritoneal Dialysis Choice of Dialysis SolutionsM. HENRY GAULT, M.D., F.A.C.P., E. L. FERGUSON, M.D., J. S. SIDHU, M.D., R. P. CORBIN, M.D. 1 January 1970Volume 72, Issue 1Page: 146-146KeywordsGlucoseHypernatremiaPeritoneal dialysisSodium Issue Published: 1 January 1970 PDF DownloadLoading ...
Goldfrank’s Toxicologic Emergencies
Authors: Daniel E. Rusyniak
Journal: JAMA (2007)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Plasma DNA, Microsatellite Alterations, and p53 Tumor Mutations Are Associated with Disease-Free Survival in Radically Resected Non-small Cell Lung Cancer Patients: A Study of the Perugia Multidisciplinary Team for Thoracic Oncology
Authors: Vienna Ludovini, Lorenza Pistola, Vanesa Gregorc, Irene Floriani, Eliana Rulli, Simonetta Piattoni, Luciana Di Carlo, Antonia Semeraro, Samir Darwish, Francesca Romana Tofanetti, Lucia Stocchi, Zhasmina Mihaylova, Guido Bellezza, Rachele Del Sordo, Giuliano Daddi, Lucio Crinò, Maurizio Tonato
Journal: Journal of Thoracic Oncology (2008)
The hemodynamic and neurohormonal effects of low doses of tezosentan (an endothelin A/B receptor antagonist) in patients with acute heart failure
Authors: Gad Cotter, Edo Kaluski, Karl Stangl, Richard Pacher, Christoph Richter, Olga Milo‐Cotter, Loïc Perchenet, Isaac Kobrin, Shoshana Kaplan, Maurizio Rainisio, Aline Frey, Eric Neuhart, Zvi Vered, Jasper Dingemanse, Guillermo Torre‐Amione
Journal: European Journal of Heart Failure (2004)
Prediction of Outcome of Surgery and Anesthesia in Patients Over 80
Authors: Jovan L. Djokovic
Journal: JAMA (1979)

We studied the outcome of surgery in 500 patients over 80 years of age. Hospital mortality within one month of surgery was 6.2%. The American Society of Anesthesiologists class 1 to 5 preoperative evaluation scale was useful in predicting death—less than 1% of class 2 patients died, 4% of class 3, and 25% of class 4. Six of seven perioperative deaths were caused by mesenteric infarction. Myocardial infarction was the leading cause of postoperative death. Twenty-four percent of 141 patients who underwent upper abdominal surgery required controlled endotracheal ventilation for more than 24 hours postoperatively; 57% after intrathoracic surgery; and only 2% after surgery that did not enter pleura or peritoneum. Forty-seven patients underwent gallbladder surgery, and 27 peripheral underwent vascular surgery without any hospital fatality. Enflurane appears to be a safe general anesthetic for sick, elderly patients. (<i>JAMA</i>242:2301-2306, 1979)
A 3-year Course of Subcutaneous Specific Immunotherapy Results in Long-term Prevention of Asthma in Children. Ten Year Follow-up on the PAT-Study
Authors: E. Valovirta, L. Jacobsen, B. Niggemann, S. Dreborg, H. Ferdousi, S. Halken, A. Host, L.A. Nordborg, A. Koivikko, C. Moller
Journal: Journal of Allergy and Clinical Immunology (2006)
Stenting After Optimal Lesion Debulking (SOLD) Registry
Authors: Issam Moussa, Jeffrey Moses, Carlo Di Mario, Giovanna Busi, Bernhard Reimers, Yoshio Kobayashi, Remo Albiero, Massimo Ferraro, Antonio Colombo
Journal: Circulation (1998)

Background —Coronary stenting has reduced restenosis in focal de novo lesions, but its impact has been less pronounced in complex lesion subsets. Preliminary data suggest a role for plaque burden in promoting intimal hyperplasia after stent implantation. The aim of this study was to test the hypothesis that plaque removal with directional atherectomy before stent implantation may lower the intensity of late neointimal hyperplasia, reducing the incidence of in-stent restenosis. Methods and Results —Seventy-one patients with 90 lesions underwent directional atherectomy before coronary stenting. Intravascular ultrasound–guided stenting was performed in 73 lesions (81%). Clinical success was achieved in 96% of patients. Procedural complications were as follows: emergency bypass surgery in 1 patient (1.4%), who died 2 weeks later; Q-wave myocardial infarction in 2 patients (2.8%); and non–Q-wave myocardial infarction in 8 patients (11.3%). None of the patients had stent thrombosis at follow-up. Angiographic follow-up was performed in 89% of eligible patients at 5.7±1.7 months. Loss index was 0.33 (95% CI, 0.26 to 0.40), and angiographic restenosis was 11% (95% CI, 5% to 20%). Clinical follow-up was performed in all patients at 18±3 months. Target lesion revascularization was 7% (95% CI, 3% to 14%). Conclusions —Directional atherectomy followed by coronary stenting could be performed with good clinical success rate. Also, these data point to a possible reduction in angiographic restenosis and a significant reduction in the need for repeated coronary interventions. Therefore, a randomized clinical trial seems appropriate to test the validity of this approach.
Anticoagulant Therapy in Acute Myocardial Infarction
Authors: Donald L. Howie
Journal: JAMA (1962)

To the Editor:—  Dr. Charles K. Friedberg's article on abandoning anticoagulants in myocardial infarction ( JAMA  180 :307 [April 28] 1962) is an incomplete analysis of the problem.  Dr. Friedberg continually speaks of the reduction in thromboembolism and ignores myocardial rupture, intimal hemorrhage, renal hemorrhage, and cerebral hemorrhage. Simply because a mode of treatment has a favorable influence on the process treated does not make the treatment practicable or desirable. For instance, bilateral pyelonephritis could be 100% cured by bilateral nephrectomy.  Dr. Friedberg points out that 100 series favor anticoagulation and only a half-dozen are against, as if scientific proof were a matter of democracy.  In analyzing the Danish series he states, Furthermore, the disproportionately low incidence of thromboembolism in the treated as compared with that in the untreated, fatal cases, indicates a much higher incidence of other serious complications in the treated cases, which casts doubt on the claims the
In vivo determination of the force of leukocyte-endothelium adhesion in the mesenteric microvasculature of the cat.
Authors: S D House, H H Lipowsky
Journal: Circulation Research (1988)

Quantitative estimates of the force of adhesion between leukocytes and endothelium were obtained from in vivo hemodynamic measurements in small venules of cat mesentery during topical application of the chemotactic compound N-formyl-methionyl-leucyl-phenylalanine (FMLP). Simultaneous measurements of upstream to downstream pressure drop, red cell velocity, microvessel hematocrit, and vessel diameter and length permitted application of the principles of momentum conservation to calculate the forces acting upon a leukocyte during adhesion to the endothelium. For venules ranging in diameter from 23 to 49 micron, the ratio of force (acting in the vessel axial direction) to wall shear stress on the endothelium fell from 14.6 X 10(-6) in small venules to 2.3 X 10(-6) dynes per dyne/cm2 in large venules; reflecting the larger pressure drops and forces attendant to greater lumen obstruction in the smaller venules. The equilibrium force representative of a balance between fluid shear stresses on the leukocyte and those at its site of contact with the endothelium ranged from 1.1 to 76.1 X 10(-5) dynes for wall shear stress ranging from 2 to 25 dynes/cm2; with venules with greater wall shear stresses having the greater leukocyte-endothelium shear force. Within individual venules, however, the force acting on a single leukocyte varied inversely with wall shear stress, most likely due to white blood cell deformation, which leads to a lessening of shear stress on the surface of the white blood cell.
Synergistic effects of UV photofunctionalization and micro-nano hybrid topography on the biological properties of titanium
Authors: Naoki Tsukimura, Masahiro Yamada, Fuminori Iwasa, Hajime Minamikawa, Wael Att, Takeshi Ueno, Lei Saruwatari, Hideki Aita, Wen-An Chiou, Takahiro Ogawa
Journal: Biomaterials (2011)
High serum corticotropin-releasing hormone (CRH) and bone marrow mast cell CRH receptor expression in a mastocytosis patient
Authors: Theoharis C. Theoharides, Anastasia I. Petra, Julia M. Stewart, Irene Tsilioni, Smaro Panagiotidou, Cem Akin
Journal: Journal of Allergy and Clinical Immunology (2014)
Effects of Changing Heart Rate in Man by Electrical Stimulation of the Right Atrium
Authors: JOHN ROSS, JOSEPH W. LINHART, EUGENE BRAUNWALD
Journal: Circulation (1965)

A technic is described for controlling the heart rate in patients with normal atrioventricular conduction by means of an electrical pacemaker catheter that stimulated the right atrium. When the heart rates of 17 patients in the resting state were elevated from an average of 80 to 121 beats/min., the cardiac indices remained virtually unchanged and averaged 3.67 and 3.72 L./min./M. 2 , respectively. Further increases in the heart rates resulted in small reductions in the cardiac indices to an average value of 3.21 L./min./M. 2 at 148 beats/min. The stroke volumes, ejection periods, and mean rates of ejection decreased as heart rate was increased. The role of heart rate in the circulatory response to exercise was examined in seven patients. When the heart rates were controlled by electrical stimulation at rates comparable to those previously achieved spontaneously during exercise, it was observed that cardiac output rose normally with exercise and that this rise was accomplished entirely through an increase in the stroke volume. In five patients the effects of isoproterenol infusion were also studied before and during control of the heart rate at the level reached spontaneously during isoproterenol administration. Again, when the heart rate was not permitted to rise, the increases in cardiac output with isoproterenol were mediated through increases in the stroke volume. These studies indicate that in the absence of augmented metabolic requirements, homeostatic mechanisms maintain cardiac output relatively constant despite large induced changes in the heart rate. However, when metabolic demands are increased by muscular exercise, or the circulation is stimulated by catecholamines, cardiac output can rise through an increase in stroke volume, even when alterations in the heart rate are prevented.
Prognostic Value of Echocardiographic Calcium Score in Patients With a Clinical Indication for Stress Echocardiography
Authors: Nicola Gaibazzi, Thomas R. Porter, Eustachio Agricola, Giovanni Cioffi, Carmine Mazzone, Valentina Lorenzoni, Lisa Albertini, Giacomo Faden, Mohammed Chamsi Pasha, Bipul Biabhav, Damiano Regazzoli, Andrea Di Lenarda, Pompilio Faggiano
Journal: JACC. Cardiovascular imaging (2015)
Incretin-Based Therapy and Risk of Acute Pancreatitis: A Nationwide Population-Based Case-Control Study
Authors: Reimar Wernich Thomsen, Lars Pedersen, Niels Møller, Johnny Kahlert, Henning Beck-Nielsen, Henrik Toft Sørensen
Journal: Diabetes Care (2015)

OBJECTIVE To investigate whether the use of incretin-based drugs (GLP-1 receptor agonists and dipeptidyl peptidase 4 [DPP4] inhibitors) is associated with acute pancreatitis. RESEARCH DESIGN AND METHODS The study was a nationwide population-based case-control study using medical databases in Denmark. Participants were 12,868 patients with a first-time hospitalization for acute pancreatitis between 2005 and 2012 and a population of 128,680 matched control subjects. The main outcome measure was the odds ratio (OR) for acute pancreatitis associated with different antihyperglycemic drugs. We adjusted for history of gallstones, alcoholism, obesity, and other pancreatitis-associated comorbidities and medications. RESULTS A total of 89 pancreatitis patients (0.69%) and 684 control subjects (0.53%) were ever users of incretins. The crude OR for acute pancreatitis among incretin users was 1.36 (95% CI 1.08–1.69), while it was 1.44 (95% CI 1.34–1.54) among users of other antihyperglycemic drugs. After confounder adjustment, the risk of acute pancreatitis was not increased among incretin users (OR 0.95 [95% CI 0.75–1.21]), including DPP4 inhibitor users (OR 1.04 [95% CI 0.80–1.37]) or GLP-1 receptor agonist users (OR 0.82 [95% CI 0.54–1.23]), or among nonincretin antihyperglycemic drug users (OR 1.05 [95% CI 0.98–1.13]), compared with nonusers of any antihyperglycemic drugs. Findings were similar in current versus ever drug users and in patients with pancreatitis risk factors. The adjusted OR comparing incretin-based therapy with other antihyperglycemic therapy internally while also adjusting for diabetes duration and complications was 0.97 (95% CI 0.76–1.23). CONCLUSIONS Our findings suggest that the use of incretin-based drugs appears not to be associated with an increased risk of acute pancreatitis.
Case 46-1966
Authors: Robert H. Schcipiro, Wallace A. Jones
Journal: New England Journal of Medicine (1966)

Presentation of Case First admission. A thirty-six-year-old woman entered the hospital because of a mass in the abdomen.Five weeks previously nausea and generalized abdominal pain developed, followed three days later by icterus of the skin and scleras, anorexia and elevation of the temperature to 103°F. The stools remained brown, but the urine became dark. Three weeks later the icterus diminished. On the day before admission a physician found an abdominal mass.The patient was born in Italy and had immigrated to the United States at the age of twenty-one years.Physical examination revealed a thin, slightly icteric woman. A . . .
"Operation Cataract": a means of reducing waiting lists for cataract operations.
Authors: H. F. Thomas, R. H. Darvell, C. Hicks
Journal: BMJ (1989)

In 1986 there were 58 000 people in England and Wales on ophthalmic waiting lists, most awaiting operations to remove cataracts.Although 97%/o of these operations were classified as non-urgent, 17% of the patients had been waiting for over a year.Most patients awaiting ophthalmic operations are elderly, and many have other disabilities that are further exacerbated by poor vision.By March 1988 the waiting lists for ophthalmic operations in England and Wales had increased to 66 000.2The size of the waiting list varies widely among districts, ranging from a few to over 1000 patients.In a fifth of districts a quarter of the patients have been on the waiting list for over a year.If waiting lists were frozen-that is, no new cases were added-it would take half of the district health authorities more than six months at present operating rates to clear the current backlog.'After reviewing the British figures Sir John Wilson, president of the International Agency for the Preven- tion of Blindness and chairman of the IMPACT Foundation, who pioneered "eye camps"-a means of doing many operations in a fairly short time-in India and Africa, suggested that an eye camp was needed in southern England.'This suggestion was taken up by Worthing District Health Authority, which in partnership with the IMPACT Foundation undertook "Operation Cataract" in 1987.The proportion of residents aged over 65 is much greater in Canterbury and Thanet health district (22%) than in England and Wales overall (15%).In August 1988, 474 patients were awaiting ophthalmic surgery in the district, of whom 217 were on Thanet's waiting list for removal of cataracts.The district health authority, after consultation with local ophthalmologists and the IMPACT Foundation, decided to carry out its own Operation Cataract to reduce this number, and this was done over 10 days in November 1988.We describe here how the scheme was organised and conducted.