tbuckley/cabot-search huggingface dataset:
The effect of ageing on phenotype and function of monocyte-derived Langerhans cells
Authors: S. Ogden, R.J. Dearman, I. Kimber, C.E.M. Griffiths
Journal: British Journal of Dermatology (2011)

With increasing age the immune system shows functional decline. In the skin this is associated with an increased incidence of epidermal malignancies and infections. Epidermal Langerhans cells (LCs) act as sentinels of the immune system, recognizing, processing and presenting antigen and inducing T-cell responses. Previous investigations have demonstrated a reduction in the number of epidermal LCs in elderly subjects. Moreover, the ability of LCs to migrate in response to tumour necrosis factor (TNF)-α, but not interleukin (IL)-1β, is significantly impaired in the elderly.To characterize further the changes in LC function that are associated with increasing chronological age, we have evaluated age-related changes in the response of monocyte-derived LCs (mLCs) to IL-1β and TNF-α.The phenotype and function of mLCs were compared in six young (≤ 30 years) and six aged (≥ 70 years) healthy individuals using a combination of flow cytometry, cytokine and chemokine array, and a Transwell migration assay.Monocytes from aged individuals were able to differentiate into LCs. There were no significant differences in expression of activation markers, or in baseline or inducible cytokine secretion, by mLCs derived from aged or young subjects. Furthermore, migration in response to a chemokine ligand, CCL19, was equivalent in both age groups.These data demonstrate that changes in LC function in the elderly are not associated with changes in systemic dendritic cell phenotype and function. Conditioning of LCs in situ by the epidermal microenvironment is likely to be more important.
Double-blind, placebo-controlled, crossover trial of inositol treatment for panic disorder
Authors: J Benjamin, J Levine, M Fux, A Aviv, D Levy, R H Belmaker
Journal: American Journal of Psychiatry (1995)

Because they found in an earlier study that inositol, an important intracellular second-messenger precursor, was effective against depression in open and double-blind trials, the authors studied its effectiveness against panic disorder.Twenty-one patients with panic disorder with or without agoraphobia completed a double-blind, placebo-controlled, 4-week, random-assignment crossover treatment trial of 12 g/day of inositol.The frequency and severity of panic attacks and the severity of agoraphobia declined significantly more after inositol than after placebo administration. Side effects were minimal.The authors conclude that inositol's efficacy, the absence of significant side effects, and the fact that inositol is a natural component of the human diet make it a potentially attractive therapeutic for panic disorder.
Surfactant changes in patients with lung cancer underwent to resection
Authors: Yordanka Yamakova, Rosen Petkov, Maya Bangyozova, Albena Jordanova, Asya Tsanova, Zdravko Lalchev, Victoria Ilieva, Vasil Stenev
Journal: European Respiratory Journal (2014)

Aim: To identify changes in the biochemical and biophysical behavior of lung surfactant (LS) in the unventilated and ventilated lung during surgery in patients with nonsmall cells lung cancer (NSCLC). The relationship between the surfactant changes and complications was examined.  Material and Methods: In prospective study we included 32 patients (SG) with NSCLC and a control group(CG) of 29 patients without cancer. Surgery was performed under general anesthesia and a double lumen tube intubation. In both groups we performed bronchoalveolar lavage (BAL): A. From the operated (nonventilated) lung after intubation and before reventilation; B. From ventilated lung after intubation and at the end of anestesia. Biochemical analysis: the amount of phospholipids, cholesterol and proteins. Biophysical analysis: the equilibrium surface tension(γ eq ) and dynamic characteristics of monolayers (minimal surface tension γ min , maximal surface tension, γ max ).  Results: In SG the amount of LS phospholipids was significantly lower, as compared to the CG (70.4 vs. 219.2 µg/mg protein). In addition, we detected an increase in the amount of the LS proteins (mg/ml) in the second samples of both lungs: ventilated (0.13 vs. 0.42) and nonventilated(0.23 vs. 0.47). We noticed a deterioration of γ eq  in cancer patients as compared to the CG (43.11 vs. 29.4 mN/m). γ min  was increased in the second samples: ventilatedlung (10.98 vs. 14.3 mN/m) and unventilatedlung (9.65 vs. 17.69 mN/m). Respiratory postoperative complications were observed - hypoventilation in 8 patients , pneumonia - in 3.  Conclusion: Lung cancer patients have changed behavior of LS. Hypoxia and inhalation anesthesia affects the biochemical and biophysical properties of LS.
A family study of obsessive-compulsive disorder
Authors: D L Pauls, J P Alsobrook, W Goodman, S Rasmussen, J F Leckman
Journal: American Journal of Psychiatry (1995)

The goal of this study was to determine 1) whether obsessive-compulsive disorder is familial, 2) whether there is a familial relationship between obsessive-compulsive disorder and Gilles de la Tourette's syndrome and chronic tics, and 3) whether different familial types of obsessive-compulsive disorder exist.In this family study, all available first-degree relatives of 100 probands with obsessive-compulsive disorder were interviewed directly with structured interviews, and best-estimate diagnoses were assigned. In addition to the 466 first-degree relatives of the probands, 113 comparison subjects who were first-degree relatives of 33 psychiatrically unaffected subjects were studied with the same interviews.The rates of obsessive-compulsive disorder and subthreshold obsessive-compulsive disorder were significantly greater among the relatives of the probands with obsessive-compulsive disorder (10.3% and 7.9%, respectively) than among the comparison subjects (1.9% and 2.0%, respectively). Furthermore, the rate of tics (Tourette's disorder and chronic tics) was also significantly greater among the relatives of the probands (4.6%) than among the comparison subjects (1.0%). The relatives of female probands with obsessive-compulsive disorder were more likely to have tics, and the relatives of probands with early onset were at higher risk for both obsessive-compulsive disorder and tics.Obsessive-compulsive disorder is a heterogeneous condition. Some cases are familial and related to tic disorders, some cases are familial and unrelated to tics, and in other cases there appears to be no family history of either obsessive-compulsive disorder or tics.
Abstract 1419: Biocompatible 3-Dimensional RGD-Modified Alginate Scaffold Designed to Enhance Cell Transplantation to Infarcted Myocardium
Authors: Hugo P Sondermeijer, Fiona See, Tetsunori Seki, Piotr Witkowski, David C Woodland, Mark A Hardy, Silviu Itescu
Journal: Circulation (2008)

Introduction Cell transplantation strategies for cardiac repair are currently limited by poor survival of transplanted cells. Three dimensional scaffolds improve cell transplant survival after delivery to infarcted myocardium. We aimed to design a biocompatible porous 3D scaffold using custom purified alginate that augments cell viability. Two-dimensional surfaces coated with cyclic RGDfK peptides have been shown to improve cell viability. We hypothesized that covalent attachment of cRGDfK peptide to an alginate scaffold would improve cell viability in 3D. Methods Cyclic RGDfK peptide modified porous scaffolds were fabricated by freeze gelation and subsequently seeded with 3x10e6 neonatal rat cardiomyocytes or 3x10e6 neonatal rat cardiac fibroblasts. Cell containing scaffolds were cultured for one week and cell viability was determined by trypan blue exclusion. Scaffolds were implanted intramuscularly in rats (n=4) for 1 month to determine biocompatibility by multinucleated giant cell formation, compared to immunogenic suture material. Efficacy of circular scaffold (16 mm x 0.75 mm) application to the epicardial surface of rat hearts (n=12) was evaluated macroscopically and by ED-2 positive macrophage staining 1 week after transplantation. Results Scaffolds with interconnected pores (100–200 μm) allowed seeding and even distribution of cells. At 1 week, neonatal rat myocyte viability inside scaffolds increased from 3.3±1.2% (0 mg/g cRGDfK) to 12.3±0.1% (10 mg/g cRGDfk) to 28.9±7.3% (10 mg/g cRGDfk + gelatin) (P&lt;0.05). Clusters of beating myocytes could be detected. Neonatal rat cardiac fibroblast viability increased from 48.8±21% (0 mg/g cRGDfK) to 77.2±3.2% (10 mg/g cRGDfK) (P&lt;0.05). One month after intramuscular scaffold implantation, 1.2±0.7 multinucleated cells could be seen per HPF throughout the scaffold, vs 17.5±4.2 around immunogenic sutures (P&lt;0.05). Scaffolds integrated with the epicardial surface 1 week after transplantation. ED-2 staining was negative. Conclusion Three dimensional scaffolds generated from custom purified alginate modified with cRGDfK peptide promote cardiac cell viability in vitro. Scaffolds are biocompatible and may be used to transplant cells to the myocardium by epicardial application.
Abstract 18304: Prognostic Value of Right Ventriclular EchoDoppler Parameters in Patients With Left Ventricular Systolic Dysfunction: Comparison to Radionuclide Right Ventricular Ejection Fraction
Authors: Pascal De Groote, Celine Goeminne, Marie Fertin, Frederic Mouquet, Sandrine Peyrot, Cedric Delhaye, Christophe Bauters, Nicolas Lamblin
Journal: Circulation (2010)

Background: In patients with reduced left ventricular ejection fraction (LVEF), right ventricle (RV) systolic parameters are powerful predictors of survival. Aim of the study: To compare the progno...
Abstract 11926: Prognostic Utility of Myocardial Single Photon Emission Computed Tomography (SPECT) with Iodine-123-Beta-Methyl Iodophenyl-Pentadecanoic Acid (BMIPP) in Risk Stratification of Nonischemic Cardiomyopathy
Authors: Yuko Utanohara, Nobuo Iguchi, Ryuta Asano, Morimasa Takayama, Jun Umemura, Tetsuya Sumiyoshi, Hitonobu Tomoike
Journal: Circulation (2011)

Background: Iodine-123-beta-methyl iodophenyl-pentadecanoic acid (BMIPP) can assess myocardial fatty acid utilization. Recently, several reports have indicated that BMIPP imaging might identify isc...
Concentration variability of potent allergens of p-tert-butylphenol-formaldehyde resin (PTBP-FR) in patch test preparations and commercially available PTBP-FR
Authors: C.R. Hamann, E. Zimerson, D. Hamann, L. Laugesen, B. Carlsson, C. Nathansen, C. Hamann, M. Bruze
Journal: British Journal of Dermatology (2011)

Journal Article Concentration variability of potent allergens of p‐tert‐butylphenol‐formaldehyde resin (PTBP‐FR) in patch test preparations and commercially available PTBP‐FR Get access C.R. Hamann, C.R. Hamann Loma Linda University School of Medicine, Loma Linda, CA 92354, U.S.ADepartment of Occupational and Environmental Dermatology, Skåne University Hospital, Lund University, SE‐205 02 Malmö, Sweden Carsten R. Hamann. E‐mail: hamann511@gmail.com Search for other works by this author on: Oxford Academic Google Scholar E. Zimerson, E. Zimerson Department of Occupational and Environmental Dermatology, Skåne University Hospital, Lund University, SE‐205 02 Malmö, Sweden Search for other works by this author on: Oxford Academic Google Scholar D. Hamann, D. Hamann Department of Occupational and Environmental Dermatology, Skåne University Hospital, Lund University, SE‐205 02 Malmö, SwedenUniversity of Arizona College of Medicine‐Phoenix, 550 East Van Buren Street, Phoenix, AZ 85004, U.S.A Search for other works by this author on: Oxford Academic Google Scholar L. Laugesen, L. Laugesen Mekos Laboratories, Herredsvejen 2, DK‐3400 Hillerød, Denmark Search for other works by this author on: Oxford Academic Google Scholar B. Carlsson, B. Carlsson Mekos Laboratories, Herredsvejen 2, DK‐3400 Hillerød, Denmark Search for other works by this author on: Oxford Academic Google Scholar C. Nathansen, C. Nathansen Mekos Laboratories, Herredsvejen 2, DK‐3400 Hillerød, Denmark Search for other works by this author on: Oxford Academic Google Scholar C. Hamann, C. Hamann SmartPractice, 3400 E. McDowell Road, Phoenix, AZ 85008, U.S.A Search for other works by this author on: Oxford Academic Google Scholar M. Bruze M. Bruze Department of Occupational and Environmental Dermatology, Skåne University Hospital, Lund University, SE‐205 02 Malmö, Sweden Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 166, Issue 4, 1 April 2012, Pages 761–770, https://doi.org/10.1111/j.1365-2133.2011.10781.x Published: 01 April 2012 Article history Accepted: 01 December 2011 Published: 01 April 2012
Evidence of increased pathogenicity of HRVC compared with HRVA and B: Comparisons between children with an acute lower respiratory illness and controls
Authors: Desmond Cox, Siew-Kim Khoo, Giovanni Ferrari, Guicheng Zhang, Wai-Ming Lee, Gary Geelhoed, Jack Goldblatt, James Gern, Joelene Bizzintino, Ingrid Laing, Peter Le Souef
Journal: European Respiratory Journal (2012)

Introduction: Recent studies suggest that human rhinovirus group C (HRVC) is more pathogenic in young children than HRVA and B. However, the relative frequency of isolation of these HRV groups between children presenting to an emergency department (ED) with an acute lower respiratory illness (ALRI) and healthy community controls has not been determined.  Aim: To compare isolation rates for HRVA, B and C between children with an ALRI presenting to ED and health community controls.  Methods: Children aged 0-5 years presenting with an ALRI to the ED of a tertiary paediatric hospital along with healthy children from a local childcare centre were prospectively recruited. A nasal sample was collected at recruitment from which RNA was extracted and reverse transcribed. From cDNA, a 2-step PCR of the HRV 59 NCR was used for HRV detection and molecular typing.  Results: There were no differences in isolation rates for HRVA between ALRI cases and controls. Isolation rates for HRVB were low and slightly higher in controls than cases. For HRVC, not only were isolation rates higher than for HRVA or B, but rates were substantially higher for cases versus controls (48.5 vs 8.7%, p  Conclusions: HRVC is the most common HRV group causing ALRI in this group of young children, but is relatively uncommon in healthy children. In contrast, HRVA and B were not more common in children with ALRI than controls. These data provide support for HRVC being more pathogenic than HRVA and B.
Smokers' characteristics, pharmacological treatment and their association with weight gain during smoking cessation
Authors: Melaine Fidelix, Suzana Tanni, Livia Baldini, Andre Bertani, Liana Coelho, Mariana Ambrosi, Carolina Mesquita, Ilda Godoy, Sergio Paiva, Irma Godoy
Journal: European Respiratory Journal (2012)

Tobacco addiction is responsible for many deaths. However, the adherence to the treatment is made difficult by several factors.  Aim:  Investigate if the weight gain during smoking cessation is associated with smokers characteristics or smoking cessation treatment strategies.  Methods:  148 smokers (female=65.5%, age=50.2±11.6y) were evaluated at baseline and after one year during a smoking cessation program. At baseline, all patients were analyzed by general date, anthropometric measurements, motivation stage, nicotine dependence, Hospital Anxiety and Depression Scale (HADS) and pharmacological treatment for smoking cessation. After one year of treatment, the patients were reevaluated for smoking cessation, weight changes. Weight gain above 3.0 kg was considered significant. We used T test, Chi 2  and multiple logistic regression.  Results:  Among 148 smokers, 81.8% received at least one pharmacological treatment and 20.2% used bupropion. After one year, 34.4% of patients (60.78% female, age: 51.5 ±11.3y) were abstinent and they gained more weight [5 (2-10) kg, p Conclusion:  Ours results confirms previous findings of weight gain after smoking cessation and did not identify association between weight gain and any patient characteristics or treatment strategy.
Abstract 18440: Hypertension Control in all Age Groups - a VA 10 Year Multicenter Analysis
Authors: Ross D Fletcher, Vasilios Papademetriou, Raya Kheirbek, Richard Amdur, Charles Faselis, Ronald Jones
Journal: Circulation (2011)

Introduction: While the benefits of blood pressure (BP) control are well known, BP control is rarely studied in large populations. Elderly patients have been considered difficult to control. We reviewed blood pressure control in a large cohort of VA patients. Methods: From September 2000 to August 2010, we assessed BP control in 582,851 hypertensive patients from 15 VA hospitals in various geographic locations around the United States. Patients were divided in 4 groups based on age: G1: &lt;55 (N=176,604), G2: 55 - &lt;70 (N=214,967), G3: 70 - &lt;80 (N=139,103), G4: &gt;80 (N=52,177). Medical interventions to control BP included use of electronic medical records with automated reminders, medical regimen adjustments, and frequent visits to both specialty and nurse run clinics. Results: Control rates (BP≤140/90) in FY00 were: 50.0% in G1, 45.5% in G2, 45.5% in G3 and 47.8% in G4. After 10 years of follow up, BP control improved to 73.6% in G1, 74.5% in G2, 75.1% in G3 and 73.2% in G4 (p&lt;0.0001 for all groups compared to baseline). In all age groups, BP levels were lower during summer as compared to winter. Diastolic BP for patients over the age of 55 approached that of those &lt; 55. Systolic and diastolic BP fell more rapidly in the first 6 years than the last 4 years. The stable diastolic BP achieved in the last 4 years permits BP control without deleterious low levels of diastolic BP in elderly patients. Conclusions: 1) All age groups can be well controlled, with lower rates of control in average systolic and diastolic BP in the last 4 years. 2) Older patients &gt; 70 yo respond well and achieve higher control rates without deleterious lowering of diastolic BP. 3) Seasonal BP variation is seen independent of age.
Safety and efficacy of tigatuzumab plus sorafenib as first-line therapy in subjects with advanced hepatocellular carcinoma: A phase 2 randomized study
Authors: Ann-Lii Cheng, Yoon-Koo Kang, Aiwu Ruth He, Ho Yeong Lim, Baek-Yeol Ryoo, Chao-Hung Hung, I-Shyan Sheen, Namiki Izumi, TaShara Austin, Qiang Wang, Jonathan Greenberg, Shinichi Shiratori, Robert A. Beckman, Masatoshi Kudo
Journal: Journal of Hepatology (2015)
Abstract 3047: Role of Pericardium in Maintaining the Left Ventricular Twist
Authors: Sung-A Chang, Kyung-II Park, Myung-Ki Suh, Seung-Pyo Lee, Hyung-Kwan Kim, Yong-Jin Kim, Seil Oh, Dae-Won Sohn, Young-Bae Park
Journal: Circulation (2009)
Tarasoff and the clinician: problems in fulfilling the duty to protect
Authors: Paul S. Appelbaum
Journal: American Journal of Psychiatry (1985)

The obligation to protect potential victims of one's patients, as first described in the California Tarasoff case, is being endorsed by an increasing number of jurisdictions. Although problematic in many respects, it has become a factor that must be dealt with in routine clinical interactions. The author presents a three-part model of the Tarasoff obligation--identifying the requirements of assessment, selection of a course of action, and implementation--and illustrates with case examples the mistakes that clinicians commonly make at each of these stages. Guidelines are suggested for a reasonable approach to dealing with the Tarasoff doctrine.
Enriching Careers in General Practice: Building an efficient and healthy practice
Authors: S Handysides
Journal: BMJ (1994)

All happy families are alike but an unhappy family is unhappy after its own fashion.'General practitioners' professional status is, or at least has been, lower than that of hospital consultants.The jibe of "perfunctory care by perfunctory men" still cuts, more than 80 years after it was made,' although the context is at least partly sympathetic-what can be expected of inappropriately trained, underpaid, over- worked doctors without effective treatments?3 Lord Moran's surprise that general practitioners (doctors who had fallen off the career ladder) could be thought equal to consultants, expressed in 1960, can still make sensitive general practitioners wonder whether con- sultants regard them as equals.This history of being overshadowed by the hospital service may explain the egalitarian philosophy in- grained in general practice.Marshall Marinker, until 12 years ago a general practitioner and now director of medical education at Merck Sharp and Dohme and visiting professor at Guy's and St Thomas's United Medical and Dental School, agrees that "there is an unwritten law that general practitioners must never be hierarchical, an unwillingness to accept that some general practitioners might be better than others, a fear of unfair competition.The BMA used to frown on ,/,
Effect of methadone plus neuroleptics on treatment-resistant chronic paranoid schizophrenia
Authors: D. A. Brizer, N. Hartman, John A Sweeney, R. B. Millman
Journal: American Journal of Psychiatry (1985)

In a placebo-controlled single-crossover study, seven patients with treatment-resistant chronic paranoid schizophrenia who received methadone plus neuroleptic showed significant improvement. Methadone may be a useful adjunctive treatment in a subpopulation of patients with chronic paranoid schizophrenia.
An outbreak of skin and soft tissue infection caused by Mycobacterium abscessus following acupuncture
Authors: S.-J. Koh, T. Song, Y.A. Kang, J.W. Choi, K.J. Chang, C.S. Chu, J.G. Jeong, J.-Y. Lee, M.-K. Song, H.-Y. Sung, Y.H. Kang, J.-J. Yim
Journal: Clinical Microbiology and Infection (2009)
HIV infection in prisons
Authors: D. Shewan, M. Reid, A. Macpherson, J. B Davies
Journal: BMJ (1995)

Extrahepatic cholestasis produced by bile duct ligation decreased the net hepatic uptake of organic anions including sllfobromophthalein, sulfobromophthalein glutathione and phenol-3,6-dibromophthalein disulfonate, and the neutral organic compound, ouabain. The net hepatic uptake of procaine amide ethobromide, an organic cation was not similarly affected. Impairment of net hepatic uptake by bile duct ligation was demonstrated by reduced liver concentration and content of administered compound despite higher plasma concentration. Acute bile duct ligation did not alter the amount of hepatic cytoplasmic anion binding proteins. The impaired net hepatic uptake of sulfobromophthalein in bile duct-ligated rats was reversed by re-establishing bile flow. Deleterious effects of endogenous bile or bile constituents and specific alteration of membrane carrier proteins are considered possible contributing factors to the impaired net hepatic uptake process observed in bile duct-ligated rats.