Studies on the Pathogenesis of Rheumatoid Joint Inflammation
Authors: RONALD A. RESTIFO
Journal: Annals of Internal Medicine (1965)

Article1 February 1965Studies on the Pathogenesis of Rheumatoid Joint InflammationIII. The Experimental Production of Arthritis by the Intra-articular Injection of Purified 7S Gamma GlobulinRONALD A. RESTIFO, M.D., ANDRE J. LUSSIER, M.D., ARNOLD J. RAWSON, M.D., JOHN H. ROCKEY, M.D., JOSEPH LEE HOLLANDER, M.D., F.A.C.P.RONALD A. RESTIFO, M.D.Search for more papers by this author, ANDRE J. LUSSIER, M.D.Search for more papers by this author, ARNOLD J. RAWSON, M.D.Search for more papers by this author, JOHN H. ROCKEY, M.D.Search for more papers by this author, JOSEPH LEE HOLLANDER, M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-62-2-285 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe finding of leukocytes containing cytoplasmic inclusion granules ("R.A. cells") in the synovial fluids of rheumatoid patients has stimulated an hypothesis for the pathogenesis of the inflammatory changes in this disease (1). This proposes that the inflamed joint results from the phagocytosis of intra-articular complexes of rheumatoid factor and 7S gamma globulin by leukocytes. Supporting such a concept are the release of rheumatoid factor from washed rheumatoid synovial fluid cells fractured by ultrasound (2), the demonstration of intracytoplasmic particulate 7S and 19S gamma globulin in rheumatoid synovial fluid leukocytes (3), and the in vitro phagocytosis of complexes of rheumatoid factor...References1. HOLLANDERRAWSONRESTIFOLUSSIER JLAJRAAJ: Studies on the pathogenesis of rheumatoid joint inflammation (abstract). Arthritis Rheum. 7: 314, 1964. Google Scholar2. HOLLANDERMCCARTYASTORGACASTRO-MURILLO JLDJGC: Studies on the pathogenesis of rheumatoid joint inflammation. I. The "R.A." cell and a working hypothesis. Ann. Intern. Med. 62: 271, 1965. LinkGoogle Scholar3. RAWSONABELSONHOLLANDER AJNMJL: Studies on the pathogenesis of rheumatoid joint inflammation. II. Intracytoplasmic particulate complexes in rheumatoid synovial fluids. Ann. Intern. Med. 62: 281, 1965. LinkGoogle Scholar4. 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HARRISVAUGHAN JJH: Transfusion studies in rheumatoid arthritis. Arthritis Rheum. 4: 47, 1961. CrossrefMedlineGoogle Scholar11. Immunological aspects of rheumatoid arthritis and systemic lupus erythematosus. Arthritis Rheum. 6: Aug. 402, 441, 1963. Google Scholar12. ISHIAZAKAISHIAZAKA IZ: Biologic activities of aggregated gamma globulin. I. Skin reactive and complement fixing properties of heat denatured gamma globulin. Proc. Soc. Exp. Biol. Med. 101: 845, 1959. CrossrefMedlineGoogle Scholar13. CHRISTIAN CL: Properties of aggregated human gamma globulin (abstract). Arthritis Rheum. 3: 268, 1960. Google Scholar14. JAMESHENNEYSTANWORTH KCSDR: Structural changes occurring in 7S gamma globulin. Nature (London) 202: 563, 1964. CrossrefMedlineGoogle Scholar15. OSTERLANDHARBOEKUNKEL CKMHG: Rheumatoid factor (7S and 19S types) reacting with different portions of the gamma globulin molecule. Arthritis Rheum. 5: 312, 1962. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: RONALD A. RESTIFO, M.D.; ANDRE J. LUSSIER, M.D.; ARNOLD J. RAWSON, M.D.; JOHN H. ROCKEY, M.D.; JOSEPH LEE HOLLANDER, M.D., F.A.C.P.Affiliations: Philadelphia, PennsylvaniaFrom the Arthritis Section, Department of Medicine, and the Department of Surgical Pathology, Hospital of the University of Pennsylvania, and the Department of Microbiology, University of Pennsylvania School of Medicine, Philadelphia, Pa.Requests for reprints should be addressed to Joseph Lee Hollander, M.D., Hospital of the University of Pennsylvania, 34th and Spruce Sts., Philadelphia, Pa. 19104. 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The "R.A. Cell" and a Working HypothesisJOSEPH LEE HOLLANDER, M.D., F.A.C.P., DANIEL J. MCCARTY JR., M.D., F.A.C.P., GONZALO ASTORGA, M.D., EDUARDO CASTRO-MURILLO, M.D. 1 February 1965Volume 62, Issue 2Page: 285-291KeywordsArthritisCellsGlobulinsHospital medicineInflammationPathogenesisPhagocytosisSurgical pathologySynovial fluidUltrasound imaging ePublished: 1 December 2008 Issue Published: 1 February 1965 PDF downloadLoading ...