tbuckley/cabot-search huggingface dataset:
Diagnostic and Therapeutic Quandaries in a Patient With a Germ Cell Tumor
Authors: Nasser Hanna, Kenneth Kesler, Lawrence Einhorn
Journal: Journal of Clinical Oncology (2001)

Article Tools SPECIAL DEPARTMENTS Article Tools OPTIONS & TOOLS Export Citation Track Citation Add To Favorites Rights & Permissions COMPANION ARTICLES No companion articles ARTICLE CITATION DOI: 10.1200/JCO.2001.19.20.4088 Journal of Clinical Oncology - published online before print September 21, 2016 PMID: 11600612 Diagnostic and Therapeutic Quandaries in a Patient With a Germ Cell Tumor Nasser HannaxNasser HannaSearch for articles by this author , Kenneth KeslerxKenneth KeslerSearch for articles by this author , Lawrence EinhornxLawrence EinhornSearch for articles by this author Show More Indiana University, Indianapolis, IN https://doi.org/10.1200/JCO.2001.19.20.4088 First Page Full Text PDF Figures and Tables © 2001 by American Society of Clinical Oncology
Waist-to-height ratio and lung function among adults. The PLATINO cohort
Authors: Ana Maria Menezes, Fernando Cesar Wehrmeister, Rogelio Perez-Padilla, Adriana Muino, Maria Victorina Lopez Varella, Gonzalo Valdivia, Carmem Lisboa, Jose R. Jardim, Carlos Talamo, Pedro C. Hallal, Maria Montes de Oca
Journal: European Respiratory Journal (2013)

Background: waist-to-height ratio (WtHR) has been used as a better indicator for obesity and fat distribution rather than body mass index or waist circumference and a possible risk for several chronic diseases, including respiratory impairment.  Aim: to evaluate the association between changes in WtHR and lung function among adults.  Methods: a follow-up was conducted in three out of the five centers of the PLATINO study: Montevideo, Santiago, and Sao Paulo, after a period of 5, 6 and 9 years, respectively. The same spirometers, questionnaires and standardized methods for measuring height and waist circumference implemented in the baseline were carried out in the follow-up. The main exposure variable was WtHR, being a cut-off point of ≥ 0.5 considered as an abdominal fat pattern; for the longitudinal analysis, this variable was categorized in four groups: low WtHR at both visits, high WtHR at the baseline, high WtHR at the follow-up visit and high WtHR at both visits. The outcomes were absolute FEV1 and FVC parameters. Unadjusted and adjusted linear regression models were performed to evaluate the association.  Results: a reduced FEV1 was observed in the crude analysis (β = -0.23L – 95% CI -0.36; -0.10) for those subjects who had a high WtHR at both visits; in the adjusted analysis the statistical significance was lost (β = -0.04L – 95% CI -0.09; 0.02); for the FVC parameter, there was a reduction in the crude and adjusted analysis ((β = -0.11L – 95% CI -0.19; -0.03) for those subjects who had a high WtHR at both visits.  Conclusion: it is suggested that the maintenance of a high waist-to-height ratio can be a predictor of low lung function, mainly FVC.
The kick with the kite: an analysis of kite surfing related off shore rescue missions in Cape Town, South Africa
Authors: A K Exadaktylos, G M Sclabas, I Blake, K Swemmer, G McCormick, P Erasmus
Journal: British Journal of Sports Medicine (2005)

This study analyses kite surfing related off shore rescue missions in Cape Town, South Africa with the aim of providing more information on the frequency, pattern, and severity of kite surfing related injuries.The observation period for this study started on October 1, 2003 and ended on May 1, 2004 and included 30 air rescue missions. Data and information were collected prospectively.The Air Mercy Service in Cape Town Province responded to 30 requests for help. Twenty five accidents were attributed to inability to detach the kite from the harness. Injuries occurred in five incidents and included fractures of the upper arm, ribs and ankle, and lacerations and contusions to the head and neck. Two patients suffered from hypothermia and one experienced severe exhaustion. All surfers were rescued successfully and there were no fatal accidents.The risk potential of this new sport is unclear. Dangerous situations can occur despite proper training and safety precautions due to unpredictable conditions and difficulties with equipment. Safety should be stressed. Surfers should sailing with a fellow kiter and should wear a life vest. More efforts must be taken to make this booming new water sport safer.
Time to Initiation of Adjuvant Chemotherapy in Patients with Rapidly Proliferating Early Breast Cancer
Authors: A. Farolfi, E. Scarpi, A. Schirone, S. Bravaccini, R. Maltoni, L. Cecconetto, S. Sarti, P. Serra, D. Amadori, A. Rocca
Journal: Annals of Oncology (2014)
Abstract 2825: Incidence, Predictors, and Outcome of Plaque Prolapse after Stent Implantation in Patients with Acute Myocardial Infarction: An Intravascular Ultrasound Analysis
Authors: Young Joon Hong, Myung Ho Jeong, Jae Youn Moon, Ju Han Kim, Jeong Gwan Cho, Jong Chun Park, Jung Chaee Kang
Journal: Circulation (2007)
Mycobacterial knee infection in patients with idiopathic inflammatory myositis
Authors: I Haq, D Isenberg, R Callaghan
Journal: Annals of the Rheumatic Diseases (2004)

We read with interest the report by Callaghan and Allen about a patient with inflammatory myositis who developed Mycobacterium malmoense infection in her right knee.1 The authors state in their discussion that they reviewed the …
Cellular and Subcellular Expression of the Monocarboxylate Transporter MCT1 in Rat Heart
Authors: Erlingur Johannsson, Erlend A. Nagelhus, Karl J.A. McCullagh, Ole M. Sejersted, Theodor W. Blackstad, Arend Bonen, Ole P. Ottersen
Journal: Circulation Research (1997)

An antibody to the C-terminus of the monocarboxylate transporter MCT1 was used to study the precise cellular and subcellular distribution of this transporter in rat heart. Postembedding immunogold procedures revealed that the labeling in the heart was restricted to cardiomyocytes and concentrated along the plasma membrane, including the transverse tubules. Gold particles occurred with highest densities in intercalated disks, where they avoided desmosomes and gap junctions. Labeling was also associated with plasmalemmal invaginations having ultrastructural features typical of caveolae. Internal membrane compartments were unlabeled. Quantitative analyses following postembedding labeling showed that the distribution of gold particles across the plasma membrane was nearly symmetrical, indicating that the C-terminus of the transporter is situated very close to the cell membrane. In preembedding immunogold experiments, the gold particles were localized at the external aspect of the plasma membrane, suggesting that the C-terminus is extracellular. From the present data, it can be concluded that even under basal conditions the majority of the MCT1 molecules in heart is present in the myocyte plasma membrane, implying that there is a constitutive functional expression of this transporter. It follows that the increased transmembrane flux of lactate during exercise or in pathological conditions such as ischemia must be a result of altered substrate gradients rather than of translocation of MCT1 molecules to the plasma membrane.
Soundings: The gas we pass
Authors: George Dunea
Journal: BMJ (2004)

Benjamin Franklin once wrote that “it is universally known that in digesting our common food there is produced in the bowels of human creatures a great quantity of wind.” As escaping gas is offensive because of its smell, and retained gas causes pain and disease, he wished one would discover a drug that “shall render the natural discharges of wind from our bodies, not only inoffensive, but agreeable as perfumes.”
TGFB1 Functional Polymorphisms: Impact on Outcome in Allogeneic Sibling Donor Haematopoietic Stem Cell Transplantation
Authors: Mariano Berro, Virginia Palau, Maria Marta Rivas, Juliana Martinez Rolon, Adriana Vitriu, Karin Padros, Guillermina Remaggi, Maria Cecilia Foncuberta, Maria Beatriz Rodriguez, Carolina Belli, Irene B Larripa, Gustavo Daniel Kusminsky
Journal: Blood (2014)
Abstract 15: Trends in Consumption of Key Foods and Nutrients Linked to Cardiometabolic Risk Among Us Adults, 1999 to 2012
Authors: Colin D Rehm, Dariush Mozaffarian
Journal: Circulation (2015)

Introduction: Most prior studies of US diet trends have evaluated macronutrients (e.g., total fat), rather than the foods and other nutrients most strongly linked to cardiometabolic risk. Assessment of these trends, including heterogeneity by age, sex, race, and education, is crucial to identify challenges and opportunities to improve the diet of Americans. Objective: To characterize trends in US dietary intakes of foods and nutrients related to cardiometabolic health. Methods: We evaluated repeated cross-sectional diet assessments among 33,929 US adults age 20+y from 6 consecutive cycles of NHANES (1999-2012). Based on an in-person 24-hour dietary recall, we evaluated energy-adjusted intakes for vegetables, fruits, whole grains, processed meat, poultry, nuts/seeds, 100% fruit juice, and sugar-sweetened beverages (SSBs); and sodium, potassium, fiber, seafood omega-3’s, and total polyunsaturated fat, among others. Analyses were further stratified by age, sex, race, and education. Results: Among all adults, significant increases were seen in yogurt, nuts/seeds, whole grains, dark-green vegetables, fruit, and poultry; processed meat also increased (Figure). Decreases were observed in potatoes, unprocessed red meats, milk, fruit juice, and SSBs. Energy-adjusted intakes of sodium, fiber, and polyunsaturated fat increased; potassium and seafood omega-3’s did not change (not shown). Trends were generally consistent within population subgroups, with some exceptions. The increase in nuts/seeds was strongest among the well-educated, the decrease in SSBs was strongest in adults 20-34y and the increase in yogurt consumption was limited to women. Conclusion: Overall US dietary habits are improving, consistent with continuing declines in population blood pressure and cholesterol; although processed meat and sodium intake are increasing. Disparities in dietary intakes by race and education did not markedly change, suggesting that additional efforts be explored to reduce disparities.
Bioactivity-guided isolation of bronchodilator fraction from clitoria ternatea roots
Authors: Dnyaneshwar Taur, Raju Patil, Ravindra Patil
Journal: European Respiratory Journal (2013)

Introduction: Asthma is regarded as a lifetime disorder of airway and which require long term multitargated therapy for its management.

Aim and Objectives: To overcome these adverse effects of synthetic drugs there is much interest in plant derived medicine for the management asthma have been increased. The roots of Clitoria ternatea Linn family Fabeaceae have been traditionally used for the treatment of asthma.

Method: In present study seven fractions F3 to F8 and F10 isolated from ethanol extract of C. ternatea (50 mg/kg) were tested on histamine induced bronchospam in guinea pig using salbutamol (2 mg/kg) as standard drug (Patel, K.G. et al. Iranian Biomedical J 2008; 12(3): 191-196). The time required for onset of preconvulsive dyspnoea was recorded. Among these most significant fraction was rechromatographed and phytoconstituent was identified by spectroscopic method.

Results: Result of study reveals that fraction F7 significantly protects guinea pig against histamine induced bronchoconstriction as shown in Figure 1.

![Figure][1] 



Compound separated from fraction F7 was identified as taraxerol.

Conclusions: In conclusion C. ternatea may be used in the treatment of asthma it may be due to presence of taraxerol.

 [1]: pending:yes
Therapeutic benefits of infrared (810-nm) diode laser macular grid photocoagulation in prophylactic treatment of nonexudative age-related macular degeneration
Authors: R.Joseph Olk, Thomas R. Friberg, Kristin L. Stickney, Levent Akduman, Keye L. Wong, Melvin C. Chen, Marc H. Levy, Charles A. Garcia, Lawrence S. Morse
Journal: Ophthalmology (1999)
Does day 11 omission of methotrexate due to toxicity influence the outcome in myeloablative hematopoietic cell transplant? Results from a single-center retrospective cohort study
Authors: B K Hamilton, L Rybicki, H Haddad, D Abounader, M Yurch, N S Majhail, R Hanna, R Sobecks, R Dean, H Liu, B Hill, E Copelan, B Bolwell, M Kalaycio
Journal: Blood Cancer Journal (2015)

Does day 11 omission of methotrexate due to toxicity influence the outcome in myeloablative hematopoietic cell transplant? Results from a single-center retrospective cohort study
Therapy-related acute myeloid leukemia with t(8;21), inv(16), and t(8;16): a report on 25 cases and review of the literature.
Authors: B Quesnel, H Kantarjian, J P Bjergaard, P Brault, E Estey, J L Lai, H Tilly, A M Stoppa, E Archimbaud, J L Harousseau
Journal: Journal of Clinical Oncology (1993)

PURPOSE To analyze therapy-related acute myeloid leukemias (tAMLs) with t(8;21), inv(16), or t(8;16). PATIENTS AND METHODS Twenty-five patients with tAML and t(8;21)(q22;q22), inv(16)(p13;q22), or t(8;16)(p11;p13) from seven centers, along with 23 previously published cases, were studied. RESULTS Twenty-six, 16, and six patients, respectively, had t(8;21), inv(16), and t(8;16). Prior cancer was a solid tumor in 27 cases, and a hematologic malignancy in all other patients. Five patients had received prior radiotherapy (RT) alone, and 43 had received prior chemotherapy with or without RT. Prior chemotherapy included a drug that directly reacts with DNA (alkylating agent or cisplatin) and/or an agent that targets topoisomerase II (ATTop, an anthracycline or derivative or, less often, epipodophyllotoxin) in most patients. The interval between prior tumor and diagnosis of tAML was less than 3 years in most cases, and only seven patients had a preleukemic phase of disease. Morphology was M2 AML for t(8;21), M4eo for inv(16), and M4 or M5 for t(8;16). Sixteen of 21 (76%), 12 of 14 (86%), and zero of four patients with t(8;21), inv(16), and t(8;16), respectively, achieved complete remission (CR) with intensive chemotherapy. The actuarial disease-free survival rate at 24 months was 47% and 54% in patients with t(8;21) and inv(16), respectively. CONCLUSION Like other tAMLs with a karyotype specific of de novo AML [balanced 11q23 rearrangement or t(15;17)], tAMLs with t(8;21), inv(16), or t(8;16) are usually characterized by a short latent period, previous treatment often combining a drug that directly reacts with DNA and an ATTop, and absence of preleukemic phase. Hematologic characteristics and response to treatment are also identical to those of de novo AML with the same karyotypes.
Phase I trial of dose escalation with growth factor support in patients with previously untreated diffuse aggressive lymphomas: determination of the maximum-tolerated dose of ProMACE-CytaBOM.
Authors: L I Gordon, J Anderson, T M Habermann, J N Winter, J Glick, R J Schilder, P Cassileth
Journal: Journal of Clinical Oncology (1996)

PURPOSE The aim of this study was to determine the maximum-tolerated dose (MTD) of cyclophosphamide, doxorubicin, etoposide, prednisone, bleomycin, cytarabine, methotrexate, and leucovorin (ProMACE-CytaBOM) when the myelotoxic drugs cyclophosphamide, doxorubicin, etoposide, and cytarabine are escalated. PATIENTS AND METHODS Thirty-eight eligible patients with diffuse aggressive non-Hodgkin's lymphoma were treated on a phase I trial of dose escalation using the ProMACE-CytaBOM regimen and granulocyte-macrophage colony-stimulating factor (GM-CSF; Schering, Kenilworth, NJ). Patients were treated with recombinant (r)GM-CSF 10 microg/kg/d subcutaneously from day 9 to 19. Twenty-seven patients had stage IV disease, four had stage III, and seven had bulky stage II. Half of the patients had bone marrow involvement. The median age was 45 years. RESULTS We found that the MTD was 200% for the escalated drugs in this regimen (although we never escalated above the MTD or defined by dose-limiting toxicity) and that the normalized dose-intensity (NDI; defined as the ratio of the received dose-intensity to the 100% dose-intensity of ProcMACE-CytaBOM) decreased with each cycle and was lower for the day-8 drug (cytarabine) than for the day-1 drugs. The complete response (CR) rate was 66%, and 92% of patients who achieved CR are alive without disease with a median follow-up time for survival of 3.6 years. CONCLUSION The MTD of cyclophosphamide, doxorubicin, etoposide, and cytarabine in the ProMACE-CytaBOM regimen given with growth factor support is 200%, and this dose should be tested in larger phase II trials.
The Antagonism of Amphetamine-Induced Symptomatology by a Neuroleptic
Authors: B. ANGRIST, H. K. LEE, S. GERSHON
Journal: American Journal of Psychiatry (1974)

A neuroleptic (haloperidol) that, in the doses used, is a specific blocker of dopamine was effective in antagonizing amphetamine-induced symptoms in eight patients. This finding suggests that dopaminergic mechanisms play an important role in amphetamine psychosis, as well as the additional possibility that these mechanisms may be important in other psychotic states.
Survey on domiciliary oxygen by concentrator in England and Wales
Authors: JC Waterhouse, J Nichol, P Howard
Journal: European Respiratory Journal (1994)

Long-term oxygen therapy is initiated in England and Wales by the patient's family doctor, sometimes at the request of a hospital consultant. Guidelines for therapy exist but are not mandatory. We wish to investigate the numbers and types of patients being treated under this regimen, the method of treatment and how they responded to their oxygen dose. We therefore interviewed and tested patients at the inception of therapy in six of the nine prescribing areas of the whole country, during August 1990 and February 1991. Main outcome measures were diagnoses, daily duration and flow prescribed, arterial oxygen saturation (SaO2) breathing air and improvement in arterial oxygen saturation on prescribed oxygen. Most patients both in summer and winter reported diagnoses of chronic bronchitis (45%) or emphysema (50%), in addition to other conditions. Most were male (58%), and most (72%) were over retirement age. Roughly half (45%) were house-bound, but only 28 (6%) were totally bedridden. Three quarters (77%) reported that a hospital consultant had told them how much oxygen to use, and in all diagnostic groups mean prescriptions exceeded 15 h.day-1 and 2 l.min-1. However, only half (54%) of the patients with complete measurements had basal arterial oxygen saturation of 90% or less at the start of treatment, together with a satisfactory improvement in arterial oxygen saturation on the prescribed flow of oxygen. In conclusion, patients are usually prescribed adequate regimens but little attempt is made to ensure that prescription is appropriate or response satisfactory. Resources continue to be used for treating patients without ensuring that they benefit.(ABSTRACT TRUNCATED AT 250 WORDS)
Impulse-oscillometry (IOS) differences in asthma and COPD patients, and healthy-subjects
Authors: Vandana Das, Kanchan Pyasi, Jyoti Londhe, Arvind Bhome, Tavpritesh Sethi, Anurag Agrawal, Sundeep Salvi, Rahul Kodgule, Bill Brashier
Journal: European Respiratory Journal (2014)

Impulse-oscillometry (IOS) measures lung-functions during tidal-breathing with multi-frequency sound-waves. However, the differences in IOS parameters between asthma and COPD are not well understood. We aimed to compare IOS parameters of asthma and COPD patients with those from healthy-subjects.  Methods : 100 stable-asthmatics, 101 stable-COPD patients and 55 healthy-subjects underwent pre-and-post-bronchodilator IOS according to ERS (2003) statement. Age-height-corrected post-bronchodilator parameters were compared between asthmatic and COPD subjects using log-transformation and ANCOVA-test.  Results : Compared with healthy-subjects, both asthmatic and COPD-subjects had higher resistance (R5Hz, R20Hz), impedance at 5Hz (Z5Hz), reactance at 5Hz (X5Hz), area-of-reactance (Ax) and resonance-frequency (Rf). Compared with asthmatics, COPD-subjects had higher Z5Hz [kPa/(L/s)] (0.69±0.37 vs 0.93±0.42, p Conclusion : Despite similarities in airway-resistances, COPD-patients exhibit lower expiratory-inspiratory resistance difference, with higher lung-impedance, lung-reactance, area of-reactance and resonant-frequency compared to asthmatics. IOS offers a comparative understanding of lung-dynamics in asthma and COPD during tidal-breathing.
Treatment outcomes and deaths among multidrug-resistant tuberculosis (MDR-TB) patients in Gomel region, Belarus - 2009-2010
Authors: Alena Skrahina, Andrei Khaliaukin, Dennis Falzon, Valiantsin Rusovich, Masoud Dara, Aliaksandr Shyrayeu, Liudmila Zhylevich, Matteo Zignol, Hennadz Hurevich
Journal: European Respiratory Journal (2013)

Background: In Gomel, a region in south-east Belarus (country population 9.5 million in 2011; Gomel 1.5 million), TB patients with strains resistant to at least isoniazid and rifampicin (multidrug-resistance;MDR-TB) have been treated using standardised regiments with second-line drugs since 2009.  Methods: We analyse factors associated with death in MDR-TB patients started on treatment in 2009-2010.  Results: Of 514 confirmed MDR-TB patients, 436 (85%) started treatment. Median age was 45y (IQR:36-52), 84% were males, 15% were HIV-infected (40% on antiretrovirals) and 6% had additional resistance to ofloxacin plus a second-line injectable (XDR). 34% of patients were successfully treated, in 13% treatment failed, 35% died, and 18% interrupted therapy. Among the 152 deaths, 64% were attributed to pulmonary TB, 25% to HIV/AIDS, 6% to associated malignancy, and 5% to other causes. At multivariable regression, death was statistically-significantly associated with age>34 y (adjusted odds ratios: 2.2; 95% confidence limits:1.2-4.2), previous treatment with second-line drugs (2.5;1.3-5.0), HIV-infection (2.9;1.5-5.8); and protective effects were associated with ethambutol (0.5;0.3-0.9), ofloxacin (0.2;0.1-0.4) and prothionamide/ethionamide (0.4;0.2-0.6).  Conclusion: In these first MDR-TB patients placed on standardised treatment, regimens were not optimised with negligible access to later-generation fluoroquinolones. Many patients had long-standing disease and more extensive lesions. No social support was provided to MDR-TB patients before 2011. With enhanced regimens, expanded access to antiretrovirals and social support, treatment outcomes are expected to improve.