tbuckley/cabot-search huggingface dataset:
Abstract 16945: Role of Thromboxane A2-Activated Nonselective Cation Channels in Hypoxic Pulmonary Vasoconstriction of Rat
Authors: Hae Young Yoo, Su Jung Park, Amy Zeifman, Yung E Earm, Jason X Yuan, Sung Joon Kim
Journal: Circulation (2011)

Hypoxia-induced pulmonary vasoconstriction (HPV) is a physiological mechanism responsible for controlling the ventilation-perfusion ratio in the lungs. Maintenance of the ventilation-perfusion rati...
Myocardial Strain and Torsion Quantified by Cardiovascular Magnetic Resonance Tissue Tagging
Authors: Marco J.W. Götte, Tjeerd Germans, Iris K. Rüssel, Jaco J.M. Zwanenburg, J. Tim Marcus, Albert C. van Rossum, Dirk J. van Veldhuisen
Journal: Journal of the American College of Cardiology (2006)
Abstract MP44: Leukocyte Telomere Length and Risks of Incident Coronary Heart Disease and Mortality in a Racially Diverse Population
Authors: Cara L Carty, Jingmin Liu, Charles Kooperberg, Megan Skinner Herndon, Andrea LaCroix, Abraham Aviv, Alexander P Reiner
Journal: Circulation (2015)

Background: Telomeres are nucleotide repeat regions at the ends of chromosomes that maintain chromosomal structural integrity and genomic stability. Telomeres from circulating leukocytes can be readily measured; mean leukocyte telomere length (LTL) tends to decrease with age, vary by race/ ethnicity and is a putative marker of cellular aging. In studies of mainly white populations, shorter LTL has been associated with cardio-metabolic risk factors and increased risks of mortality and coronary heart disease (CHD), yet it is not clear whether these findings extend to other race/ethnicity groups. We sought to assess the relationship of LTL with risks of incident CHD and total mortality in a racially diverse population of post-menopausal women. Methods: Using a nested case-cohort design, African American (AA) and white women with incident CHD or mortality during a maximal follow-up of 19.4 years were randomly selected from the Women’s Health Initiative. LTL from baseline blood samples was assayed by Southern blotting. Race-stratified and risk factor-adjusted Cox proportional hazards models, weighted to account for the sampling scheme, were used to estimate the hazard of CHD or mortality. Results: A total of 1,525 women (858 whites and 667 AA) were included in the analyses. In whites, there were 367 incident CHD (292 mortality) events, while AA experienced 269 incident CHD (265 mortality) events. Cross-sectional LTL associations (p&lt;0.05) with age, current smoking, and US recruitment region were observed in AA, whereas in whites, LTL was associated with age, current smoking and HDL cholesterol. Whites with longer LTL at baseline were less likely to have incident CHD, HR=0.58 (95%CI: 0.40-0.84), p=0.004, yet no significant association was observed in AA, HR=1.07 (95%CI: 0.71-1.61), p=0.74. This LTL-CHD association varied significantly by race/ethnicity, p=0.028. Similar trends were observed for total mortality, with longer LTL associated with reduced hazard in whites, HR=0.70 (95%CI: 0.46-1.06), but a slightly increased hazard in AA, HR=1.10 (95%CI: 0.80-1.53), though neither association was significant. In exploratory analyses of cause-specific mortality, increased LTL was associated with an increased, but non-significant hazard of cancer mortality in both AA and whites, p=0.17 and 0.28 respectively. Conclusion: We describe LTL associations with incident mortality, CHD and cardiovascular risk factors in post-menopausal women; these findings appear to vary by race/ethnicity. As a marker of chronic inflammation and cellular stress, LTL is robustly associated with CHD in whites, even after adjustment for cardio-metabolic risk factors including C-reactive protein, yet it does not appear to be associated with CHD in AA. Future studies exploring these race-specific differences may be warranted.
Reduction of particles by using a particle separator in pig barn environment reduces inflammatory response in healthy volunteers
Authors: Anna Hedelin, Britt-Marie Sundblad, Kjell Larsson, Lena Palmberg
Journal: European Respiratory Journal (2012)

The pig farming environment is a well-known inducer of upper and lower airway inflammation and it is unknown what causes the strong inflammatory response.

The objective was to investigate if the number or size distributions of particles in the barn dust affect the airway inflammatory reaction in healthy volunteers.

Two identical barns were cleaned and a particle separator (CentriClean System AB) was installed in one stable before the pigs were housed for ten weeks. Twelve non-smoking volunteers were exposed while weighing pigs for 3 hours to normal pig house environment and particle separated pig house environment (6 in each group, cross-over design) with 2-4 weeks between the two exposures.

Initial particle (0.3µm-25µm) analyses showed e.g. 2-4 fold higher particle numbers in an ordinary pig barn than in particle separated barn.

There were increase in body temperature, exhaled NO and almost all perceived symptoms while FEV1, PD20FEV1 (methacholine), VC and PEF were reduced in all subjects after exposure to pig barn in comparison to filtered milieu. No significant changes were seen between the exposures except for body temperature (p=0.034).

IL-8 and IL-6 in nasal lavage fluid and CD14-expressing monocytes in blood increased more after exposure to swine barn in comparison to the air filtered swine barn (p=0.040, p=0.021 and p=0.034 respectively).

The results indicate that reduction in particles exposure of pig barns affect both local and systemic inflammatory responses in healthy persons after acute exposure to swine barn environment.
Houston 5, Atlanta 8
Authors: Fran Markover
Journal: JAMA (2002)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
An approach to monitoring influenza vaccination uptake across Europe
Authors: M. Kroneman, W  J Paget, L. E. Meuwissen, C Joseph, H Kennedy
Journal: Eurosurveillance (2008)

Currently, the monitoring of influenza vaccination uptake is mainly a national issue. As influenza infection easily crosses international borders, it is in the interest of all countries to have a high vaccine uptake in people who may be vulnerable when influenza spreads. A Europe-wide monitoring system can provide insight into the strengths and weaknesses of uptake rates in countries and, on ce sufficient levels are achieved, can safeguard the continuation of the achieved levels. This paper aims to address the following issues: a) How is influenza vaccination uptake monitored in Europe? b) What methods to monitor vaccination uptake are available and what are their limitations? c) What steps should be taken to implement a European-wide influenza vaccination uptake monitoring system? Based on existing literature and experiences in monitoring influenza vaccination uptake, an approach to set up a European-wide monitoring system is proposed. The following issues were identified as relevant for influenza vaccination uptake monitoring: a) Agreement on the population groups in which vaccination uptake should be monitored; b) The frequency of data collection; c) The importance of sharing experiences regarding existing influenza vaccination campaigns in order to learn from each other, and develop 'best practices'; d) The need to publish uptake data in close relation with influenza surveillance data and other European efforts on dissemination of vaccination knowledge. To stimulate the discussion on implementing a pan-European influenza uptake monitoring scheme the following recommendations were suggested : a) Develop a common set of variables; b) Build on experience from individual countries; c) Create a coordinating body; d) Create or identify a platform to publish the data; e) Start small and expand rapidly.
Tungiasis: eggs seen with dermoscopy
Authors: R. Cabrera, F. Daza
Journal: British Journal of Dermatology (2007)

Journal Article Tungiasis: eggs seen with dermoscopy Get access R. Cabrera, R. Cabrera Department of Dermatology, Clínica Alemana, Universidad del Desarrollo, Manquehue Norte 1410, 7650567 Santiago, Chile Search for other works by this author on: Oxford Academic Google Scholar F. Daza F. Daza Department of Dermatology, Clínica Alemana, Universidad del Desarrollo, Manquehue Norte 1410, 7650567 Santiago, Chile Correspondence: F. Daza E‐mail: mdazap@udd.cl Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 158, Issue 3, 1 March 2008, Pages 635–636, https://doi.org/10.1111/j.1365-2133.2007.08376.x Published: 01 March 2008
Ventilator-induced heat shock protein 70 and cytokine mRNA expression in a model of lipopolysaccharide-induced lung inflammation
Authors: Harriët A. Vreugdenhil, Jack J. Haitsma, Koos J. Jansen, Jitske Zijlstra, Frans B. Plötz, Jaap E. van Dijk, Burkhard Lachmann, Hans van Vught, Cobi J. Heijnen
Journal: Intensive Care Medicine (2003)
Effectiveness of Over-the-Counter Nicotine Replacement TherapyRisk of Hemolytic Uremic Syndrome From Antibiotic Treatment of
Authors: Mikael Franzon, Gunnar Gustavsson, Barbara H. Korberly
Journal: JAMA (2002)

To the Editor: Drs Pierce and Gilpin1 conclude that nicotine replacement therapy (NRT) has not increased smoking cessation rates since it became available over-the-counter. We do not believe that the authors can draw such efficacy conclusions from this nonrandomized, noncontrolled study.
Teasing Out Effects of Estrogen on the Brain
Authors: M J Friedrich
Journal: JAMA (2002)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Reply
Authors: Mazen Noureddin, Elizabeth C. Wright, Marc G. Ghany
Journal: Hepatology (2013)

We appreciate the insightful comments by Grebely et al. regarding the role of HCV RNA levels on disease outcome among persons with advanced chronic hepatitis C virus (HCV).1 We performed the requested analysis to address the issue. HCV RNA levels were available on all patients from the HALT-C cohort but only from 108 of the 246 patients from the NIH cohort. In the cross-sectional analysis, the mean HCV RNA level was higher between the HALT-C cohort compared to the NIH cohort, 6.40 log10 IU/mL (SD 0.56) versus 5.58 log10 IU/mL (SD 0.90), P < 0.0001, respectively. For both cohorts combined, HCV RNA levels were higher among patients with IL28B CC genotype (6.39 log10 IU/mL, SD 0.78) compared to IL28B TT genotype (6.23 log10 IU/mL, SD 0.53), P = 0.0013, but not IL28B CT genotype (6.34 log10 IU/mL, SD 0.59), P = 0.28. When CC was compared to CT and TT combined (mean 6.31, SD 0.78), the P-value was 0.087. Analyzing the two cohorts separately revealed no difference between IL28B genotypes CC and CT/TT in the NIH cohort, 5.51 log10 IU/mL (SD 1.00) for those with CC and 5.63 log10 IU/mL (SD 0.83) for those with IL28B CT/TT, P = 0.52. However, in the HALT-C cohort the mean was 6.53 log10 IU/mL (SD 0.64) for those with IL28B genotype CC and 6.35 (SD 0.53) for those with genotype CT/TT, P < 0.0001. The observation that HCV RNA levels did not differ between IL28B CC and non-CC genotypes in the NIH cohort could have been due to the small sample size. Importantly, in multivariate analysis, HCV RNA levels were neither associated with fibrosis progression (P = 0.61) nor clinical outcomes (P = 0.75). Thus, while we found HCV RNA levels to be higher among patients with IL28CC genotype, as demonstrated previously by Grebely et al.,2 they did not influence fibrosis progression or clinical outcomes. Further studies are needed to investigate why patients with IL28 CC genotype have worse clinical outcomes compared to non-CC patients. This research was supported by the Intramural Research Program of the NIDDK, NIH. Mazen Noureddin, M.D.1 Elizabeth C. Wright, M.D.2 Marc G. Ghany, M.D.1 1Liver Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 2Office of the Director, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD
Fortnightly review: Acute dystonia induced by drug treatment
Authors: P. N van Harten, H. W Hoek, R. S Kahn
Journal: BMJ (1999)

Acute dystonia induced by drug treatment can be a side effect of treatment with antipsychotic drugs and other drugs, and it may occur at an early stage of treatment.1 2 Acute dystonia is often frightening and may seriously disturb the relationship between the doctor and the patient. Therefore, every doctor who prescribes dopamine blocking agents should be familiar with the prevalence of and the risk factors for acute dystonia and should know how to prevent and treat the condition.

#### Summary points

Acute dystonia induced by drug treatment can be caused by antipsychotic, antiemetic, and antidepressant drugs

Acute dystonia caused by drug treatment can seriously disturb the relationship between doctor and patient and should be prevented

Patients who develop abnormal positioning or muscle spasms within seven days of starting drug treatment or of a rapid increase in the dose of a drug may be diagnosed with acute, drug induced dystonia

Biperiden 5 mg should be administered intramuscularly to treat the condition; this is nearly always effective within 20 minutes

Risk factors for acute, drug induced dystonia include young age, male sex, use of cocaine, and a history of acute dystonia

Drug induced dystonia can be prevented either by adding, during the first four to seven days of treatment, anticholinergic drugs to treatment with antipsychotic drugs or by starting treatment with atypical antipsychotics

We searched Medline and Embase for the period 1980-98 using the key terms extrapyramidal syndromes, dyskinesia, dystonia, movement disorders, side effects, and antipsychotics, and we checked the reference lists of the articles that we identified. This information supplemented our own research into extrapyramidal side effects induced by antipsychotic drugs.3–5

Acute dystonia induced by antipsychotic drugs is described as “sustained abnormal postures or muscle spasms that develop within seven days of starting or rapidly raising the dose of …
TONSILLITIS ASSOCIATED WITH ACUTE ASEPTIC MENINGITIS
Authors: David Riesman
Journal: Annals of Internal Medicine (1936)

Case Reports1 April 1936TONSILLITIS ASSOCIATED WITH ACUTE ASEPTIC MENINGITISDAVID RIESMAN, M.D., Sc.D., F.A.C.P.DAVID RIESMAN, M.D., Sc.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-9-10-1427 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptCASE REPORTSCase 1. Mr. I. B., a married man of 45 years, a native of New York City, had always enjoyed good health. On Tuesday, April 4, 1933, he awoke with a severe headache and a sore throat. The headache was obstinate, not yielding, to codeine or other anodynes. Sinus roentgen-ray and blood Wassermann test were negative. The blood count was entirely normal, the fasting sugar 120 mg. per 100 c.c. of blood. The tendon reflexes were exaggerated on the right side and the Babinski reflex was present on that side. Eye ground examination showed dilated vessels but no...Bibliography1. KROLL M: Die neuropathologischen Syndrome (zugleich Differentialdiagnostik der Nervenkrankheiten), 1929, J. Springer, Berlin, 456. CrossrefGoogle Scholar2. WALLGREN A: Meningitis "aseptica" acuta, Wien. Arch. f. inn. Med., 1926, xii, 297-312. Google Scholar3. VIETSWATTS HRJW: Aseptic (lymphocytic) meningitis, Jr. Am. Med. Assoc., 1929, xciii, 1553-1555; Acute aseptic meningitis, Jr. Nerv. and Ment. Dis., 1934, lxxv, 253-273. CrossrefGoogle Scholar4. DICKENS PF: Aseptic (lymphocytic) meningitis, U. S. Nav. Med. Bull., 1932, xxx, 362-366. Google Scholar5. ARMSTRONGLILLIE CRD: Experimental lymphocytic choriomeningitis of monkeys and mice, Pub. Health Rep., 1934, xlix, 1019-1027. CrossrefGoogle Scholar6. RIVERSSCOTT TMTF: Meningitis in man caused by a filterable virus, Science, 1934, lxxxi, 439-440. Google Scholar7. ARMSTRONGDICKENS CPF: Benign lymphocytic choriomeningitis, Pub. Health Rep., 1935, l, 831-842. CrossrefGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Philadelphia, Pennsylvania*Read before the Section on Medicine of the College of Physicians of Philadelphia, February 25, 1935; with additions. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byLIII The Underlying Factors Concerned in Otitic Hydrocephalus 1 April 1936Volume 9, Issue 10Page: 1427-1430KeywordsAnalgesicsBloodBlood countsCodeineHeadachesHematologic testsMeningitisPharyngitisReflexesTendons ePublished: 1 December 2008 Issue Published: 1 April 1936 PDF downloadLoading ...
Abstract 169: Maintenance of breast cancer stem cells in an inert matrix is mediated by mesenchymal stem cells in the tumor stroma
Authors: Samaneh K. Sarvestani, Danial Barati, Esmaiel Jabbari
Journal: Cancer Research (2014)

Abstract Introduction: Cancer stem cells (CSCs) hypothesis relates cancer recurrence to a small population of tumor cells with the ability to self-renew to maintain the tumor mass. Recent studies demonstrate that conventional therapies eliminate the differentiated cells that form bulk of the tumor, while leaving CSCs unharmed. There is increasing evidence that the maintenance of CSCs in the tumor tissue is regulated by microenvironment. In particular, human mesenchymal stem cells (hMSCs) and associated soluble factors as part of the tumor stroma play a significant role in self-renewal and maintenance of CSCs (1). Our laboratory has developed an inert 3D synthetic matrix with defined properties that maintains and enriches the CSC sub-population of tumor cells within a certain range of stiffness (2). The objective of this work was to investigate the effect of co-encapsulation of MDA-MB-231 (MDA) human breast cancer cells with human hMSCs in the engineered patterned matrix on tumorsphere formation and CSC maintenance. Methods: Thee effect of MSCs on MDA cells was investigated in a patterned matrix with defined stiffness to control tumorsphere size. To separate the patterned cellular matrix from the glass substrate, a layer of the gel without cells was first crosslinked on the glass substrate by UV radiation. Next, a mixture of MDA and hMSCs (5x105 cells/mL each) in the hydrogel precursor solution was patterned by UV radiation on the gel covered glass slide with a UV mask. The stiffness of the matrix was controlled by the concentration of macromer in the hydrogel precursor solution. Tumorsphere size and density, and expression of CSC markers were determined with incubation time in tumor CSC culture medium. Results and Conclusion: The micro-patterned 3D synthetic hydrogel matrix with defined modulus supported tumorsphere formation and expression of CSC markers. Specifically, co-culture of MDA cells with hMSCs increased the expression of CD44 and ABCG2 markers of stemness by three-fold after 6 days of encapsulation in the engineered matrix from 25 to 58 for CD44 and 14 to 42 for ABCG2. Likewise, tumorsphere density more than doubled and average tumorsphere diameter increased from 25 to 47 µm after 6 days of incubation when MDA cells were co-encapsulated with hMSCs. The model inert matrix can be used to understand the effect of individual cell types in the tumor stroma on CSC maintenance and tumorigenesis. Citation Format: Samaneh K. Sarvestani, Danial Barati, Esmaiel Jabbari. Maintenance of breast cancer stem cells in an inert matrix is mediated by mesenchymal stem cells in the tumor stroma. [abstract]. In: Proceedings of the 105th Annual Meeting of the American Association for Cancer Research; 2014 Apr 5-9; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2014;74(19 Suppl):Abstract nr 169. doi:10.1158/1538-7445.AM2014-169