tbuckley/cabot-search huggingface dataset:
Spectre of Noah
Authors: Jesse Roth
Journal: JAMA (2004)

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Abstract 17065: The Relationship Between Insulin-Like Growth Factor-1 and Augmentation Index, Independent of Pulse Wave Velocity
Authors: Jaewon Oh, Sungha Park, Nak Hoon Son, Dong-Jik Shin, Sang-Hak Lee, Seok-Min Kang, Sun Ha Jee, Yangsoo Jang
Journal: Circulation (2011)

Introduction: Insulin-like Growth Factor (IGF)-1 is associated with aging and recently linked to metabolic syndrome and cardiovascular disease. However, little is known about the relationship between IGF-1 and arterial stiffness such as augmentation index (AIx) and pulse wave velocity (PWV). We assessed the hypothesis that IGF-1 was independently associated with arterial stiffness. Methods: We measured the plasma IGF-1 level of 1114 subjects (724 males, 57.2 ±10.1 years old) using commercially available assays. Arterial stiffness parameters were assessed via VP-2000 pulse wave unit. Results: Our study included 875 (78.5%) hypertension, 580 (52.1%) coronary artery disease, and 177 (15.9%) diabetes mellitus patients. Elderly age group (age≥65 years, n=298) had lower IGF-1 (87.0 vs. 101.6ng/ml) but higher AIx (24.8 vs. 19.9%), heart to femoral PWV (hfPWV) (1110.3 vs. 936.0cm/s), brachial to ankle PWV (baPWV) (1583.2 vs. 1406.0 cm/s) compared with middle age group (age&lt;65 years, n=816). IGF-1 was correlated with AIx (r=-0.211, p&lt;0.001), hfPWV (r=-0.135, p&lt;0.001) and baPWV (r=-0.157, p&lt;0.001). Multiple linear regression analysis showed that IGF-1 was significantly associated with AIx after adjusting for age, gender, body mass index, systolic blood pressure, high sensitive C-reactive protein and hfPWV (p=0.019, r 2 =27.0%). This association strengthened in middle age group (p&lt;0.001, total r 2 =31.7%) but disappeared in elderly age group. Conclusion: In conclusion, IGF-1 was associated with AIx independent of PWV especially in middle age group. The independent relationship between IGF-1 and AIx provides insight into the pathophysiologic mechanisms of arterial stiffness in cardiovascular disease.
Neuroblastoma-targeted nanocarriers improve drug delivery and penetration, delay tumor growth and abrogate metastatic diffusion
Authors: Irene Cossu, Gianluca Bottoni, Monica Loi, Laura Emionite, Alice Bartolini, Daniela Di Paolo, Chiara Brignole, Francesca Piaggio, Patrizia Perri, Angelina Sacchi, Flavio Curnis, Maria Cristina Gagliani, Silvia Bruno, Cecilia Marini, Alessandro Gori, Renato Longhi, Daniele Murgia, Angela Rita Sementa, Michele Cilli, Carlo Tacchetti, Angelo Corti, Gianmario Sambuceti, Serena Marchiò, Mirco Ponzoni, Fabio Pastorino
Journal: Biomaterials (2015)
An Increase in Baseline Level of Urinary Liver-Type Fatty Acid-Binding Protein Linked with Poor Prognosis after Allogeneic Hematopoietic Stem Cell Transplantation
Authors: Naoki Shingai, Taku Morito, Shuntaro Ikegawa, Keita Yamamoto, Yutaro Hino, Kaito Harada, Aiko Igarashi, Ken Watanabe, Yasushi Senoo, Yuho Najima, Noriko Doki, Takeshi Kobayashi, Kazuhiko Kakihana, Kazuteru Ohashi, Hisashi Sakamaki, Minoru Ando
Journal: Blood (2014)
Abstract 3767: Plaque Characterization by Coronary CT Angiography in Asymptomatic Type II Diabetes: Vulnerable Subjects are Missed with Coronary Artery Calcium Scoring?
Authors: Hyuk-Jae Chang, Eue-Keun Choi, Sang-Il Choi, Yong-Seok Cho, Woo-Young Chung, In-Ho Chae, Dong-Ju Choi, Cheol-Ho Kim, Sung-Hee Choi, Soo Lim, Hak C Jang
Journal: Circulation (2007)
Abstract 2309: Intra-Valve Hemorrhage is Associated with Increased Inflammation, Neovascularization and Calcification in Patients with Severe Aortic Stenosis
Authors: Pedro R Moreno, Luis M Astudillo, Elias Zias, Kothandaraman Purushothaman, Meerarani Purushothaman, David H Adams, Patrick Lento, John T Fallon, Valentin Fuster
Journal: Circulation (2008)

Intra-plaque hemorrhage is a manifestation of inflammation and neovascularization in atherosclerosis that may also play a role in severe calcific aortic stenosis (AS). This study tested the hypothesis that intra-valve hemorrhage (IVH) will have increased inflammation and neovascularization in severe AS. From Jan-Dec 2006, 94 patients underwent surgery for AS. Tissue specimens from all 94 valves were evaluated (H&amp;E stain). IVH was defined as erythrocyte extravasation mostly located in severely calcified areas, as shown in Figure . Seven specimens displayed IVH. Of the remaining 87 specimens without IVH, 44 served as controls. Immunohistochemistry was performed to quantify macrophage/T cell infiltration (CD-68+CD-3), and neovessel content (CD-34). Calcification (graded on a scale from 1 to 4) was also perfomed. IVH patients were younger (59 ± 12 versus 69 ± 9; P&lt; 0.05). Gender, risk factors, coronary disease, aortic valve area, gradient, and ejection fraction were similar in both groups. Macrophage/T cell content was increased in IVH when compared to controls (59 ± 22 versus 28 ± 22; P&lt; 0.05). Neovascularization was also increased in IVH when compared to controls (32 ± 6 versus 23 ± 10; P&lt; 0.05). Finally, calcification score was also increased in IVH when compared to controls (3.9 ± 0.4 versus 3 ± 0.9; P&lt; 0.01). IVH is associated with younger age, increased inflammation, neovascularization, and calcification in severe AS. These results suggest that IVH may play a role in the pathobiology of severe AS, accelerating the process of inflammation and calcification, which may trigger symptoms at a younger age.
Die gezielte funktionsgerechte Einführung der Miller-Abbott-Sonde unter endoskopischer Kontrolle
Authors: K. Meissner, W. Weissenhofer
Journal: Endoscopy (1976)

Based on experiences with 9 treatments in 7 cases of intestinal obstruction, the technique of endoscopic transgastric guidance of Miller-Abbott-tubes is reported. On our service, the above mentioned method was applied in the treatment of intestinal obstruction observed in cases of advanced malignant lesions as well as in patients with intestinal obstruction in the early postoperative period. Apparative aids and technical guidelines are accentuated. The method requires a team consisting of at least one physician and three assistents with clearly defined competence. Success also depends on the selection of material used. Special problems arise in the treatment of patients following partial gastrectomy. Routine X-rays are important in order to control the course of treatment and to documentate the result. The inclusion of endoscopic aids resulted in successful intestinal intubation in all cases treated. The utilization of recommended guidelines seemingly rules out technical failure in the attempt of placing the tube in the desired anatomic position.
Major Abdominal Surgery in the Over-Eighties
Authors: C A Palmer, H Reece-Smith, I Taylor
Journal: Journal of the Royal Society of Medicine (1989)

We report a prospective controlled trial looking at the outcome of major abdominal surgery judged on the ability of patients to return to their preoperative activity level. Eighty patients were included in the study. Forty of these were over 80 years old and the remainder in the age group 40–65 years. Fifty-four per cent of the over 80s demonstrated an increased level of dependance six months after surgery compared to 18% of the 40–65 year olds. The mortality rate at six months was 42% for the over 80 group. The poor prognosis of elderly surgical patients not only in their increased mortality rate but also in their dependency should be considered before they are subjected to major abdominal surgery.
Abstract 13827: The Influence of Cytochrome 2c19 Allelic Variants on Clopidogrel-Mediated Platelet Inhibition Evaluated by Five Different Platelet Function Tests
Authors: Thomas Gremmel, Christoph W Kopp, Deddo Moertl, Daniela Seidinger, Renate Koppensteiner, Simon Panzer, Christine Mannhalter, Sabine Steiner
Journal: Circulation (2010)

Objectives: The antiplatelet effect of clopidogrel has recently been linked to cytochrome P450 (CYP) 2C19 carrier status. In order to study the impact of CYP2C19 allelic variants on clopidogrel-med...
Diazepam-induced amnesia: a neuropharmacological model of an "organic amnestic syndrome"
Authors: Owen M. Wolkowitz, Herbert Weingartner, Karen Thompson, David Pickar, Steven M. Paul, Daniel W. Hommer
Journal: American Journal of Psychiatry (1987)

Diazepam has well-known amnestic properties. These effects, however, are selective for certain psychobiologically distinct memory functions. In this study, incremental doses of diazepam administered to 10 normal volunteers selectively impaired anterograde episodic memory and attention while totally sparing access to information in long-term memory (semantic or knowledge memory). This pattern of disruption mimics that seen in patients with organic amnesias and is in sharp contrast to the pattern seen in patients with dementia. These findings provide a framework for defining specific psychobiological determinants of cognitive failure.
Abstract 15561: Does Lead Introduction Site Affect Pacing Lead Fracture Rate? Insights From a Long-Term Analysis in a Large Sample.
Authors: Fabio Quartieri, Steve Compton, Goran Milasinovic, Jill op den Kamp, Shelby Li, Brian Ramza
Journal: Circulation (2010)

Introduction: Long-term data in a large sample investigating the affect of brady pacing lead introduction site on rate of lead fractures is not frequently reported. Data from Medtronic's System Lon...
Surveillance of human listeriosis in France, 2001-2003
Authors: V Goulet, C Jacquet, P Martin, V Vaillant, E Laurent, H de Valk
Journal: Eurosurveillance (2006)

Mandatory notification of listeriosis began in France in 1999. Enhanced public health surveillance, including routine molecular characterisation of Listeria monocytogenes strains, epidemiologic follow up of cases, and collection of food samples, has improved the sensitivity of outbreak detection and response. The incidence of listeriosis declined from 4.5 cases/million in 1999-2000 to approximately 3.5 cases/million during the period 2001-2003. Clinical, demographic and microbiological characteristics of listeriosis in France remained stable during this time period. Maternal-fetal infections accounted for 24% of all cases. Serovar 4b accounted for 49% of cases and 60% of case clusters. The incidence of listeriosis in France has declined and is now lower than in several other European countries.
Abstract 2443: Utility of Isoproterenol During Catheter Ablation of Paroxysmal Atrial Fibrillation
Authors: Hakan Oral, Thomas Crawford, Melissa Frederick, Nitesh Gadeela, Alan Wimmer, Sujoya Dey, Jean F. Sarrazin, Michael Kuhne, Nagib Chalfoun, Darryl Wells, Eric Good, Krit Jongnarangsin, Aman Chugh, Frank Bogun, Frank Pelosi, Fred Morady
Journal: Circulation (2007)

Background:  Assessment of inducibility of AF by isoproterenol (ISO) infusion may be helpful during catheter ablation for paroxysmal atrial fibrillation (PAF). However, there are limited data on the clinical utility and diagnostic accuracy of isoproterenol in patients with PAF.   Methods and Results:  ISO was infused at 5, 10, 15, and 20 μg/min at 2-min intervals until max dose was reached or AF was induced in 20 control subjects with no history of atrial fibrillation and in 80 patients with PAF. In patients with PAF, antral ablation was performed to isolate all pulmonary veins (PVs) after induction of AF by ISO (or rapid pacing if ISO did not induce AF). After restoration of sinus rhythm by ablation or cardioversion, ISO was readministered using the same protocol. Among the 20 control subjects AF (1) or premature atrial depolarizations (PADs, 1) was induced in 2 patients (10%) only after 20 μg/min of ISO. Among 80 patients with PAF, AF (67) or PADs (2) was induced in 69 patients (86%, P   Conclusions:  ISO at doses up to 20 μg/min has a high sensitivity (87%) and specificity (90%) for induction of AF in patients with PAF. Inducibility of AF by ISO may suggest that the mechanism of AF depends on the PVs and/or their antrums.
Predicting acute maxillary sinusitis
Authors: F. Dobbs
Journal: BMJ (1995)

emphasis on the health benefits of activity of moderate intensity.'The Northern Ireland health and activity survey, a cross section survey of 1600 subjects aged 16-74 in Northern Ireland, found that 18% of men and 16% of women, achieved moderate activity of 20 minutes' duration in a four week period through cycling.2Thirty one per cent of men and 20% of women aged 16-34 had cycled to this level.Of those aged 35-54, 10% of men and 13% of women were active to this level through cycling, while among those aged 55-74 the proportions had fallen to 5% and 3% respectively.Of all forms of sport and recreation, cycling was one of those most often recorded in the four week period, in the previous year, and since the age of 14; overall, 37% of men and 26% of women had cycled in the previous year and 53% of men and 36% of women had cycled on some occasion since the age of 14.Clearly, there are opportunities for using cycling as a foundation for an improvement in population levels of physical activity.
Abstract 2767: A New Diagnostic Test For Arrhythmogenic Right Ventricular Cardiomyopathy
Authors: Angeliki Asimaki, Harikrishna Tandri, Hayden Huang, Marc Halushka, Cristina Basso, Gaetano Thiene, Adalena Tsatsopoulou, Nikos Protonotarios, William J McKenna, Hugh Calkins, Jeffrey E Saffitz
Journal: Circulation (2008)
End-of-life legislation in Israel: Physician attitudes and awareness.
Authors: D. Doron, I. D. Wexler, E. Shabtai, B. W. Corn
Journal: Journal of Clinical Oncology (2010)

e19641 Background: End of life (EOL) treatment decisions are influenced by religious/ethical beliefs, hospital protocols, and legislated policy. Recently, Israel passed EOL legislation that allows for indirect cessation of life-support in terminal patients or treatments that alleviate suffering but hasten death (double-effect). The purpose of this study was to determine physician attitudes and awareness regarding Israel's EOL legislation. Methods: After IRB-approval was granted, surveys were distributed to 270 physicians involved in the care of terminal patients. Physician attitudes towards EOL treatment were assessed based on response to different situations involving terminal patients using a 5 point Likert scale. Physicians were also queried regarding EOL legislation. Results: One hundred surveys were filled out appropriately and evaluated (37%) using parametric and logistic regression statistical methods. A substantial majority of physicians supported legislation that allows patients to refuse mechanical ventilation (95%) or nutritional support (72%). Nearly all physicians (93%) agreed that terminal patients should receive maximal analgesia even if it would hasten their death. Only 32% of physicians approved of legislation permitting physician assisted suicide. Physician's awareness of the law was selective. Only 28% knew the legal criterion defining a terminal patient. However, most physicians (97%) were aware that physician assisted suicide was prohibited. Self-identified level of religiosity was related to progressive attitudes towards EOL legislation with religious physicians expressing more conservative attitudes (e.g., opposing physician assisted suicide) regarding euthanasia (p = 0.001). Physicians, whether religious or not, were more willing to support acts hastening the end of life in situations of physical versus psychological discomfort (p < 0.0001). Conclusions: Increasing numbers of Israeli physicians support a terminal patient's right to refuse life-extending treatments. Support for physician assisted suicide was related to level of religiosity. Despite sharp differences regarding active euthanasia, most physicians support passive euthanasia for terminal patients. No significant financial relationships to disclose.
Abstract 4114: Identification of Gap Lesions Following Failed Atrial Fibrillation Ablation: Using Three-Dimensional Delayed Enhancement MRI to Guide Re-ablation Procedure
Authors: Troy J Badger, Robert S Oakes, Eric N Fish, Nathan M Segerson, Nazem W Akoum, Nathan S Burgon, Swati N Rao, Akram Shabaan, Edward V DiBella, Rob S MacLeod, Nassir F Marrouche
Journal: Circulation (2008)

Objectives. Pulmonary vein antrum (PVA) isolation is a common ablation strategy to treat patients with atrial fibrillation (AF). Incomplete lesion formation around the PVA is thought to contribute to recurrence of AF. We report a new multi-step approach to ensure complete PVA scarring by using 3D delayed enhancement MRI (DE-MRI) models of the LA to show regions needing ablation during repeat procedure. Methods. Five patients who suffered AF recurrence following PVAI elected to undergo a second procedure. All 5 patients received DE-MRI scans 3 months following each procedure. 3D segmentation of the LA was performed to evaluate for complete PVA scarring. Application of a color look-up table was used to illuminate scar tissue. Regions of healthy PVA myocardium was marked following the failed ablation and targeted during repeat procedure. Results. All patients showed incomplete PVA scarring after the first ablation. All patients had increased PVA scarring following the repeat procedure. 4 (80%) patients were free of AF (determined by 8 day Holter recordings, ECG and event monitoring) at 3-month follow-up. The figure below shows lack of continuous scar (orange/white) around the left and right PVA following the failed procedure. Gap lesions of healthy myocardium (blue) were identified and targeted (yellow arrows) prior to repeat ablation. Following the successful repeat procedure, all four PVA had continuous scar lesions. Conclusion. 3D DE-MRI models of the LA may identify gaps in RF lesions following failed PVA isolation. These 3D models may assist in procedure planning for the second ablation procedure by identifying the regions necessary for re-ablation.
Abstract 1604: Improved Cardiac Function after Expression of the Human Elastin Gene in the Infarcted Myocardium
Authors: Shu-Hong Li, Zhuo Sun, Lily Guo, Mihan Han, Richard D Weisel, Ren-Ke Li
Journal: Circulation (2008)

Rationale: After a myocardial infarction, necrosed cardiomyocytes are replaced by fibrotic tissue. Subsequent thinning and expansion of this non-elastic scar contributes to cardiac dilatation and congestive heart failure. We attempted to restore the elastic properties of the scar by implanting the infarct area with cells expressing elastin. Methods: Full-length elastin cDNA was generated by PCR using the human lung cDNA library, and then transfected (in adenoviral vector) into rat bone marrow stromal cells (BMSCs). Western blot and immuno-staining confirmed expression of elastin protein. Seven days after coronary artery ligation, BMSCs transfected with genes for either adeno-elastin (BMSC+Elastin) or adeno-green fluorescence protein (BMSC), or media (control group) were injected into the infarct area of adult rats (n=8/group). Results: Over 8 weeks following cell or media implantation, cardiac function (fractional shortening by echocardiography), ventricular volumes, and load independent indices of cardiac function (end systolic and diastolic volumes, preload recruitable stroke work and end systolic elastance by pressure-volume catheter), were all significantly better preserved in both BMSC groups (p&lt;0.05 vs. media), with further improvements in the BMSC+Elastin group (p&lt;0.05 vs. BMSC group). Biochemical analysis detected over-expression of recombinant elastin, and histological examination revealed that collagen fiber length and diameter were preserved in the scar tissue. Myocardial birefringence determined by polarized light (linear retardance of the tissue structure) was significantly highest in the infarct area of the BMSC+Elastin group (p&lt;0.05 compared to BMSC and media groups). Elastin over-expression by cell-based gene therapy restored the elastic matrix structure in the scar tissue, stabilized the infarct and prevented ventricular dilatation, producing the smallest (p&lt;0.05) scar size and surface area in the BMSC+Elastin group. Conclusions: Over-expression of elastin in transplanted BMSCs contributed to the alignment and organization of an elastic extracellular matrix structure, which prevented cardiac dilatation and dysfunction. Elastin plays a key role in the remodeling of the extracellular matrix.
NCCN Task Force Report: Management of Patients with Gastrointestinal Stromal Tumor (GIST)—Update of the NCCN Clinical Practice Guidelines
Authors: George D. Demetri, Robert S. Benjamin, Charles D. Blanke, Jean-Yves Blay, Paolo Casali, Haesun Choi, Christopher L. Corless, Maria Debiec-Rychter, Ronald P. DeMatteo, David S. Ettinger, George A. Fisher, Christopher D. M. Fletcher, Alessandro Gronchi, Peter Hohenberger, Miranda Hughes, Heikki Joensuu, Ian Judson, Axel Le Cesne, Robert G. Maki, Michael Morse, Alberto S. Pappo, Peter W. T. Pisters, Chandrajit P. Raut, Peter Reichardt, Douglas S. Tyler, Annick D. Van den Abbeele, Margaret von Mehren, Jeffrey D. Wayne, John Zalcberg
Journal: Journal of the National Comprehensive Cancer Network (2007)

The NCCN Soft Tissue Sarcoma Guidelines include a subsection about treatment recommendations for gastrointestinal stromal tumors (GISTs). The standard of practice rapidly changed after the introduction of effective molecularly targeted therapy (such as imatinib and sunitinib) for GIST. Because of these changes, NCCN organized a multidisciplinary panel composed of experts in the fields of medical oncology, molecular diagnostics, pathology, radiation oncology, and surgery to discuss the optimal approach for the care of patients with GIST at all stages of the disease. The GIST Task Force is composed of NCCN faculty and other key experts from the United States, Europe, and Australia. The Task Force met for the first time in October 2003 and again in December 2006 with the purpose of expanding on the existing NCCN guidelines for gastrointestinal sarcomas and identifying areas of future research to optimize our understanding and treatment of GIST. ( JNCCN 2007;5[Suppl 2]:S1–S29)