tbuckley/cabot-search huggingface dataset:
Abstract 17184: CMR Derived Myocardial Mechanics in Patients With Systemic Sarcoidosis
Authors: Veronica Rolim S. Fernandes, Beatriz Jauregui Garrido, Maria E Siqueira, Jonathan Katz, Adam Jacobi, Valentin Fuster, Jagat Narula, Javier Sanz
Journal: Circulation (2014)

Objective: To assess myocardial mechanics by cardiac magnetic resonance (CMR)-derived strain in patients with biopsy-proven systemic sarcoidosis. Methods: We included 50 consecutive patients (age 51 ± 11 years old, 30 males) with biopsy-proven systemic sarcoidosis who underwent gadolinium-enhanced CMR for suspected cardiac sarcoid involvement. Late gadolinium enhancement (LGE) was considered positive if showing an intramyocardial/subepicardial location with a nonischemic pattern. From cine images and using dedicated software (TomTec©), we quantified mean left ventricular (LV) longitudinal, radial, and circumferential peak strains as the average of 16 standard myocardial segments. We also randomly selected from our database 15 control subjects without structural heart disease (age 41 ± 11 years old, 5 males). Results: Both mean longitudinal strain (LS) and LV ejection fraction (LVEF) were lower in sarcoid patients than controls (-11.8 ± 7.3% vs. -18.1 ± 3.9%, p55%, n=32) mean LS was reduced compared to controls (-12.2 ± 7.8% vs. -18.1 ± 3.9% respectively, p=0.01; Fig 1B). There was no correlation between LVEF and mean LS (r=-0.11, p=0.65). We found no significant differences in circumferential or radial strains. LGE was present in 16 patients (32%). Sarcoid patients with LGE showed significantly less mean LS than those without (-8.5 ± 8.4% vs. -13.6 ± 6.4%, p&lt;0.001; Fig 1A) although LVEF did not differ significantly (52% vs. 59%, p=0.35). No significant differences in circumferential or radial strains were found. Conclusions: In patients with systemic sarcoidosis, evaluation of cardiac mechanics with CMR detects myocardial dysfunction even in the presence of preserved LVEF. This is more pronounced in patients with positive LGE. The potential diagnostic and prognostic significance of CMR-derived myocardial strain in sarcoidosis deserves further investigation.
Abstract 270: The association between medical history and breast cancer risk: A nationwide population-based case-control study using claim data
Authors: Shu-Chun Chuang, Guo-Jie Wu, Yen-Shen Lu, Ching-Hung Lin, Chao Agnes Hsiung
Journal: Cancer Research (2014)

Abstract Introduction: It is suggested that chronic disease may be associated with increased cancer risk due to common risk factors, treatments to the prior conditions, or other unknown mechanisms. We evaluated the associations between prior medical conditions and subsequent breast cancer risk using the claim data from the Taiwan National Health Insurance (NHI) program. Material and Method: A matched case-control study was conducted using the NHI 1,000,000 random sample dataset. A list of medical conditions based on literature review was retrieved for each case and control. The odds ratios (OR) and 95% confidence intervals (CI) of the association between medical conditions and breast cancer risk were estimated using conditional logistic regression and adjusted for occupation and number of breast cancer screening. The associations were estimated for younger (&amp;lt;50 years old) and older subjects, separately. Results: Prior breast diseases, hypertensive diseases, and endometriosis were associated with increased breast cancer risk in both age groups. Thyroid diseases were associated with breast cancer in the younger (OR=1.32, 95% CI=1.04-1.66) but not in the older group (OR=1.02, 95% CI=0.82-1.27). On the other hand, metabolic syndrome, particularly the disorders involved lipid metabolism, was associated with breast cancer only in the older group (OR=1.24, 95% CI=1.04-1.49). Conclusion: Our analyses support results from previous studies that prior breast diseases and endometriosis were associated with subsequent breast cancer at all ages, thyroid diseases were associated with premenopausal, and metabolic syndrome were associated with postmenopausal breast cancer. Note: This abstract was not presented at the meeting. Citation Format: Shu-Chun Chuang, Guo-Jie Wu, Yen-Shen Lu, Ching-Hung Lin, Chao Agnes Hsiung. The association between medical history and breast cancer risk: A nationwide population-based case-control study using claim data. [abstract]. In: Proceedings of the 105th Annual Meeting of the American Association for Cancer Research; 2014 Apr 5-9; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2014;74(19 Suppl):Abstract nr 270. doi:10.1158/1538-7445.AM2014-270
Abstract 17128: Pathophysiology of Coronary Artery Disease in Hiv-infected Patients: Dissociation Between Anatomy and Function
Authors: Massimo Mancone, Alessandra Cinque, Noemi Bruno, Alessandra Armato, Nicolò Salvi, Andrea Ceccacci, Pasqualina Bruno, Gennaro Sardella, Gabriella d’Ettorre, Vincenzo Vullo, Francesco Fedele
Journal: Circulation (2014)

Introduction: Numerous reports suggest, among HIV+ patients (pts), an increased rate of acute coronary syndrome and cardiac death. Several data suggest that endothelial dysfunction is a major mechanisms in the development of coronary atherosclerosis in non-HIV infected patients. Hypothesis: The aim of our study is to assess coronary microvascular function using Doppler-flow wire in HIV+ patients in therapy with HAART. Methods: Thirteen HIV-infected patients were enrolled from the Department of Cardiovascular, Respiratory, Nephrology, Anesthesiology and Geriatric Sciences of the “Sapienza” University of Rome (Italy). The main inclusion criteria were: Framingham risk score &lt;10%, absence of metabolic syndrome (according to the definition of Adult Treatment Panel III e ATPIII12), negative echocardiographic and ECG stress-test and negative for anti-HCV antibodies. Diagnostic coronary angiography was performed via percutaneous radial approach. Microvascular function was assessed by measuring coronary flow velocity reserve (CFR). Intracoronary functional tests were performed to evaluate both endothelium-dependent microvascular function [via intracoronary (IC) infusion of acetylcholine (2.5[[Unable to Display Character: &amp;#8211;]]10 μg)] and non-endothelium-dependent microvascular function [via IC infusion of adenosine (5 μg) ]. Results: All the patients presented a Framingham risk score &lt;10%. The medium age was 53.3±4.1 years. The mean duration of highly active antiretroviral therapy was 12.9±2.4 years. Thirteen patients presented 23 coronary atherosclerotic plaques; while endothelium and non endothelium-dependent microvascular function was quite normal in our population (CFR after adenosine 2.37±0.4; CFR after Achetylcholine 2.43±0.4). Conclusion: Microvascular function is not compromised in HIV + pts who presented coronary atherosclerotic plaque. Microvascular dysfunction, involved in pathophysiology of coronary artery disease in general population, seems to be not implicated in coronary atherosclerosis in HIV + pts. These data suggest a peculiar pathophysiological mechanisms for HIV related atherosclerosis.
EXPERIMENTAL RUBELLA IN HUMAN VOLUNTEERS
Authors: S G ANDERSON
Journal: JAMA (1949)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
SUDDEN MAJOR ARTERIAL OCCLUSION IN THE UPPER EXTREMITY OF A DIABETIC: CASE REPORT
Authors: B G MCLAUGHLIN, R F BRADLEY
Journal: Annals of Internal Medicine (1955)

Case Reports1 December 1955SUDDEN MAJOR ARTERIAL OCCLUSION IN THE UPPER EXTREMITY OF A DIABETIC: CASE REPORTB. G. MCLAUGHLIN, R. F. BRADLEYB. G. MCLAUGHLINSearch for more papers by this author, R. F. BRADLEYSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-43-6-1330 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptSudden occlusion of a major artery in the upper extremity has recently been observed in a diabetic patient. Peripheral vascular disease, usually manifested by thrombosis of or, rarely, by embolism to a major vessel, is frequently seen in this clinic. However, the overwhelming majority of such lesions have involved the lower extremities. Occlusion of a major vessel supplying an upper extremity has been extremely rare, although before the use of sulfonamides or antibiotics1gangrene requiring amputation occurred in five cases secondary to severe infection. Gangrene has occurred in such other unusual sites as neck, skin, nose, tongue, lungs, vulva and...Bibliography1. JoslinRootWhiteMarble EPHFPA: The treatment of diabetes mellitus, 1952, Lea and Febiger, Philadelphia, p. 591. Google Scholar2. See reference 1, page 602. Google Scholar3. AllenBarkerHines EVNWEA: Peripheral vascular disease, 1946, W. B. Saunders Co., Philadelphia, p. 313. Google Scholar4. See reference 3, page 317. Google Scholar5. Bell ET: A postmortem study of 1,214 diabetic subjects with special reference to the vascular lesions, Proc. Am. Diabetes A. 10: 62, 1950. Google Scholar6. WarrenLeCompte SP: The pathology of diabetes mellitus, 1952, Lea and Febiger, Philadelphia, p. 138. Google Scholar7. WilsonRootMarble JLHFA: Controlled versus free diet management of diabetes, Diabetes 1: 33, 1952. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: *Received for publication September 29, 1954. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 December 1955Volume 43, Issue 6Page: 1330-1334KeywordsLesionsLungsOverweightPeripheral vascular diseaseRetinitisStaphylococcal infectionStreptococcal infectionsSulfonamideThrombosisTongue ePublished: 1 December 2008 Issue Published: 1 December 1955 PDF downloadLoading ...
Do we need a new word for patients? Let's do away with "patients" Commentary: Leave well alone
Authors: J. Neuberger, R. Tallis
Journal: BMJ (1999)

Do we need a new word for patients?In these days of public involvement and active participation, has the term "patient" become an offensive anachronism or does it capture what is positive about the special relationship between health workers and ill people?A former chairman of the Patients' Association and a clinician argue for and against "patients."
Age-related prevalence of cross-reactive antibodies against influenza A(H3N2) variant virus, Germany, 2003 to 2010
Authors: B Blümel, B Schweiger, M Dehnert, S Buda, A Reuss, I Czogiel, P Kamtsiuris, M Schlaud, C Poethko-Müller, M Thamm, W Haas
Journal: Eurosurveillance (2015)

To estimate susceptibility to the swine-origin influenza A(H3N2) variant virus (A(H3N2)v) in the German population, we investigated cross-reactive antibodies against this virus and factors associated with seroprotective titre using sera from representative health examination surveys of children and adolescents (n = 815, 2003–06) and adults (n = 600, 2008–10). Antibodies were assessed by haemagglutination inhibition assay (HI); in our study an HI titre ≥ 40 was defined as seroprotective. We investigated associated factors by multivariable logistic regression. Overall, 41% (95% confidence interval (CI): 37–45) of children and adolescents and 39% (95% CI: 34–44) of adults had seroprotective titres. The proportion of people with seroprotective titre was lowest among children younger than 10 years (15%; 95% CI: 7–30) and highest among adults aged 18 to 29 years (59%; 95% CI: 49–67). Prior influenza vaccination was associated with higher odds of having seroprotective titre (odds ratio (OR) for children and adolescents: 3.4; 95% CI: 1.8–6.5; OR for adults: 2.4; 95% CI: 1.7–3.4). Young children showed the highest and young adults the lowest susceptibility to the A(H3N2)v virus. Our results suggest that initial exposure to circulating seasonal influenza viruses may predict long-term cross-reactivity that may be enhanced by seasonal influenza vaccination.
Abstract 16257: Blocking of Wnt/Frizzled Signaling Stops the Dilatation of the Left Ventricle After Myocardial Infarction
Authors: Hilde Laeremans, Evangelos P Daskalopoulos, Ben J Janssen, W Matthijs Blankesteijn
Journal: Circulation (2011)

Purpose: Current pharmacotherapy can not stop the left ventricular (LV) dilatation that occurs after myocardial infarction (MI). However, this would be of utmost clinical relevance to prevent the d...
Protection against Plasmodium falciparum malaria in chimpanzees by immunization with the conserved pre-erythrocytic liver-stage antigen 3
Authors: Pierre Daubersies, Alan W. Thomas, Pascal Millet, Karima Brahimi, Jan A.M. Langermans, Benjamin Ollomo, Lbachir BenMohamed, Bas Slierendregt, Wijnand Eling, Alex Van Belkum, Guy Dubreuil, Jacques F.G.M. Meis, Claudine Guérin-Marchand, Sylvie Cayphas, Joe Cohen, Hélène Gras-Masse, Pierre Druilhe
Journal: Nature Medicine (2000)
Notch signalling in primary cutaneous CD30+ lymphoproliferative disorders: a new therapeutic approach?
Authors: M.R. Kamstrup, E. Biskup, R. Gniadecki
Journal: British Journal of Dermatology (2010)

Background The oncogenic potential of deregulated Notch signalling has been described in several haematopoietic malignancies. We have previously reported an increased expression of Notch1 in primary cutaneous CD30+ lymphoproliferative disorders, lymphomatoid papulosis and primary cutaneous anaplastic large‐cell lymphoma (pcALCL). Objectives To investigate the functional importance of Notch signalling in cell lines derived from pcALCL. Methods Cell lines derived from pcALCL (Mac1, Mac2a and JK) were treated with different γ‐secretase inhibitors (GSIs) (GSI I, IX, XX and XXI). The effects of GSIs on cell viability, apoptosis and cell cycle progression were measured as well as the impact of GSI I on the known prosurvival pathway Akt–mTOR–FOXO3a. Results Notch family members were expressed in all investigated pcALCL cell lines. GSI I had a marked proapoptotic effect, but GSI IX, XX and XXI were much less potent. The GSI I‐triggered apoptosis was preceded by an accumulation of cells in the G2/M, cyclin B1‐controlled phase of the cell cycle accompanied by an increase in the cyclin‐dependent kinase inhibitor, p21WAF/Cip. GSI I induced the nuclear translocation of proapoptotic FOXO3a, probably via an Akt‐independent pathway. Conclusions Notch signalling may be a future therapeutic target for the treatment of advanced pcALCL.
Drug points: Tinnitus and ciprofloxacin
Authors: J Paul, N M Brown
Journal: BMJ (1995)

Drs J PAUL (Public Health Laboratory, John Radcliffe Hospital, Oxford OX3 9DU) and N M BROWN (Department of Microbiology, Southmead Hospital, Bristol BS10 5NB) write: Tinnitus is not generally recognised as an adverse reaction to treatment with ciprofloxacin. An incidence of only three cases per 9473 courses of treatment has been reported,1 and animal studies have failed to associate ciprofloxacin with ototoxicity.2 3 Eleven previous cases of tinnitus linked …
Industrial Action by Radiographers
Authors: P. G. T. Ford
Journal: BMJ (1974)

175 despite Dr. Cleary's doubts, becomes easier with dis sort of help.I have previously reported an so trals5 -one for murder, the other for druniken driving-in which air encephalographic evidence of cerebral atrophy was instr- mental in preventing a mnscarriage of justice in the first case and a manifestly in- appropriate sentence in the other.In a more recent trial6 the defence, learning tht the acused -had a documented history of alocyholism, rightly raised the possibility of brain damage.The air encephalography re- vealed no atrphy and it was possible to discount this suggestion beyond all reason- able, or even unresonable, doubt.He was found guilty of murder.The most questionable of Dr. Cleary's thoughts is that psychiatric evidence should be given after the verdict rather than before.I have pointed out7 that in the case of Carl Sodemn 4 hanged in Ausalia in 1936 despite unopposed psychiatric testimony that he was "McNaughton insane," cerebrl atrophy and probably menigits were found at necropsy.Air studies could have detected this before death and would probably -have influenced any appeal in his favour.Execu- tion is now unfashioble, but the possi- bility of further useful mvestgaion still dfiinishes sharply after conviction since there is an understandable reluctance ito permit action which, might 'lead to a retrial.
Prevalence and incidence of dermatitis herpetiformis: a 40-year prospective study from Finland
Authors: T.T. Salmi, K. Hervonen, H. Kautiainen, P. Collin, T. Reunala
Journal: British Journal of Dermatology (2011)

Background Dermatitis herpetiformis (DH) is an external manifestation of coeliac disease presenting with blistering rash and pathognomonic cutaneous IgA deposits. Better knowledge of subclinical forms and serological testing has resulted in a sharp increase in the incidence and prevalence of coeliac disease. Objectives To investigate the prevalence of DH and analyse whether the incidence of DH changed when the occurrence of coeliac disease increased. Methods All 477 patients with DH diagnosed from 1970 onwards at the Tampere University Hospital were analysed for prevalence in 2009. The incidence of DH was calculated in three 10-year periods from the year 1980. Results The prevalence of DH was 75·3 per 100 000 which is eight times lower than the prevalence of coeliac disease in our area. The annual incidence of DH in the whole period was 3·5 per 100 000, and in the three 10-year periods 5·2, 2·9 and 2·7 per 100 000, respectively. The decrease in incidence between the first and second 10-year period was significant (P < 0·001). The male to female ratio of DH was 1·1 : 1. The mean age at diagnosis increased significantly during the study, in men from 35·3 to 51·1 years and in women from 36·3 to 45·8 years. Conclusions The present study shows the highest prevalence of DH reported to date. Although the overall incidence of DH was also high, a significant decrease occurred in the 1990s, which is in contrast to the incidence of coeliac disease.
Cancer and Scientific Research.
Authors: Barbara Holmes
Journal: JAMA (1931)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Abstract 15365: Sleep-Disordered Breathing is Associated with Subclinical Myocardial Injury and Disease Severity in Pulmonary Hypertension Patients
Authors: Takashi Kohno, Yuichi Tamura, Takashi Kawakami, Masaharu Kataoka, Yuichiro Maekawa, Motoaki Sano, Keiichi Fukuda
Journal: Circulation (2014)

Background: Sleep disordered breathing (SDB) is well known to be associated with increased mortality in patients with left-heart failure, however the clinical significance of SDB in patients with pulmonary hypertension (PH) is not established. We sought to investigate the association of SDB with hemodynamic parameters and serum troponin T concentrations in patients with PH. Methods and Results: Overnight polygraphy was performed in 107 clinically stable patients with PH (pulmonary arterial hypertension n=52 [idiopathic n=23, collagen disease n=11, congenital heart disease n=6, others n=12]and chronic thromboembolic PH n=55), and evaluated apnea-hypopnea index (AHI; 7.6±9.3, obstructive apnea 1.8, central apnea 0.4, and hypopnea 5.3 events/h). Based on AHI, these patients were divided into two groups: non SDB (AHI&lt;15/h, n = 90) and SDB groups (AHI≧15/h, n = 17). The presence of SDB was associated with older age (p&lt;0.05), but not associated with gender, BMI, smoking, and the presence of hypertension, dyslipidemia, and diabetes mellitus. Hemodynamic studies showed that SDB patients had higher mean pulmonary artery pressure (mPA; 38±13 vs. 31±12 mmHg, p&lt;0.05), higher pulmonary vascular resistance (PVR; 9.4±7.5 vs. 5.2±3.6 Wood, p&lt;0.05) and lower cardiac output (3.4±0.9 vs. 4.8±1.9 L/min, p&lt;0.05), but PCWP did not differ between two groups. In laboratory study, plasma BNP and serum CRP levels were not associated with SDB. However, high-sensitivity troponin T (hsTnT) level was significantly higher in patients with SDB than those without (0.017±0.014 vs. 0.008±0.006 ng/mL; p&lt;0.05). HsTnT level positively correlated with plasma BNP level, mPA, PVR, and WHO functional class, and negatively correlated with cardiac output and 6 minute-walking distance (all p&lt;0.05). Furthermore, after adjustment for age, lower eGFR, hypertension, smoking, and plasma BNP level in multiple regression analysis, the presence of SDB was the independent factor to determine plasma level of log hsTnT (β = 0.19, p&lt;0.05). Conclusions: SDB is associated with subclinical myocardial damage and disease severity in patients with PH, suggesting the role of SDB-related myocardial injury in the vicious circle leading to hemodynamics destabilization and adverse prognosis.
The HMG-CoA reductase inhibitor simvastatin activates the protein kinase Akt and promotes angiogenesis in normocholesterolemic animals.
Authors: Yasuko Kureishi, Zhengyu Luo, Ichiro Shiojima, Ann Bialik, David Fulton, David J. Lefer, William C. Sessa, Kenneth Walsh
Journal: Nature Medicine (2000)