tbuckley/cabot-search huggingface dataset:
A randomized, placebo-controlled trial of intravenous recombinant tissue-type plasminogen activator and emergency coronary angioplasty in patients with acute myocardial infarction.
Authors: E J Topol, W W O'Neill, A B Langburd, J A Walton, P D Bourdillon, E R Bates, C L Grines, A M Schork, E Kline, B Pitt
Journal: Circulation (1987)

To determine the role of tissue-type plasminogen activator (t-PA) and immediate percutaneous transluminal coronary angioplasty (PTCA) in treating patients with evolving transmural myocardial infarction, 50 patients received t-PA (1.25 mg/kg iv over 3 hrs) or placebo according to 3:1 double-blind randomization 3.8 +/- 1.1 hr after onset of symptoms. At emergency coronary arteriography, patency of the infarct-related vessel was demonstrated in 32 of 38 (84%) patients receiving t-PA vs two of 12 (17%) receiving placebo (p less than .001). Of the 32 patients with recanalization after t-PA, 28 had a residual stenosis of at least 50% and underwent randomization a second time to immediate (n = 15) or no PTCA (n = 13). Immediate PTCA of the infarct-related vessel was successful in all 15 patients, with reduction of the residual diameter stenosis from 80.8 +/- 8.2% to 32.5 +/- 15.6% (p less than .001). The incidence of postinfarction angina (greater than or equal to 20 min of chest discomfort and reversible electrocardiographic changes) and reinfarction (documented by recurrent creatine kinase isoenzyme elevation) was reduced in the patients receiving t-PA and PTCA (2/15) compared with that in patients receiving t-PA alone (7/13; p = .006). At 1 week there was no difference in patency of the infarct-related vessel (12/15 t-PA and PTCA vs 9/13 t-PA only) or in global ventricular functional change between the two groups (0.5 +/- 10.4 SD/chord for t-PA and PTCA vs -2.1 +/- 8.2 SD/chord for t-PA only).(ABSTRACT TRUNCATED AT 250 WORDS)
First AHA Statement on Tobacco and Children
Authors: Andrew A. Skolnick
Journal: JAMA (1994)

THE AMERICAN Heart Association (AHA) has released a draft of its first scientific statement on the effects of passive smoking on the health of children. The statement, prepared by the AHA's Committee on Atherosclerosis and Hypertension in Children and endorsed by the American Academy of Pediatrics (AAP) and the American Thoracic Society, will be published in the association's journal<i>Circulation</i>. It was released following the Children's Heart Health Conference, held in Chicago, Ill. Entitled "Active and Passive Tobacco Exposure: A Serious Pediatric Health Problem," the report is a major review of the medical literature that links smoking and passive smoking to a wide variety of health problems in children. See also p 843. AHA speakers stressed the importance of studies that show that active and passive smoking cause immediate physiological changes and illnesses in children—not just cancer, cardiovascular disease, emphysema, and other diseases that show up much later in life.
Esophageal Carcinoma with Membranous Nephropathy
Authors: PAUL S. HECKERLING
Journal: Annals of Internal Medicine (1985)

Letters and Corrections1 September 1985Esophageal Carcinoma with Membranous NephropathyPAUL S. HECKERLING, M.D.PAUL S. HECKERLING, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-103-3-474_1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: Nephrotic syndrome, secondary to immune-complex glomerulonephritis, has been reported in association with several types of extrarenal carcinomas (1-3). Only one case of nephrotic syndrome associated with carcinoma of the esophagus has been described (4). The renal lesion in that case proved to be membranoproliferative glomerulonephritis. We report the case of a patient with esophageal cancer and nephrotic syndrome secondary to membranous nephropathy.A previously healthy 65-year-old man presented with odynophagia and dysphagia for solid foods, accompanied by ankle swelling, of 6 months' duration. Physical findings included 2+ pitting edema of both legs but were otherwise unremarkable. Esophagoscopy...References1. LEE J, YAMAUCHI H, and HOPPER J. The association of cancer and the n phrotic syndrome. Ann Intern Med. 1966;64:41-51. LinkGoogle Scholar2. EAGEN J and LEWIS E. Glomerulopathies of neoplasia. Kidney Int. 1977;11:297-306. CrossrefMedlineGoogle Scholar3. PAPPER S. Nephrotic syndrome and neoplasm. Postgrad Med. 1984;76:147-58. CrossrefMedlineGoogle Scholar4. WALKER J, O'NEILL S, and CAMPBELL E. Carcinoma of the esophagus associated with membrano-proliferative glomerulonephritis. Postgrad Med J. 1981;57:592-6. CrossrefMedlineGoogle Scholar5. ROSSEN R, REISBERG M, HERSH E, and GUTTERMAN J. Measurement of soluble immune complexes: a guide to prognosis in cancer patients [Abstract]. Clin Res. 1976;24:462A. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: PAUL S. HECKERLING, M.D.Affiliations: Rush-Presbyterian-St. Luke's Medical Center Chicago, IL 60612 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byA patient with esophageal cancer showing remission of nephrotic syndrome after esophagectomy: report of a caseParaneoplastic glomerular diseases and malignanciesCausal Relationships between Esophageal Squamous Cell Carcinoma and Nephrotic SyndromeOesophageal basaloid squamous cell carcinoma: a unique clinicopathological entity with telomerase activity as a prognostic indicatorGlomerulonephritis Associated with Basaloid Squamous Cell Carcinoma of the Oesophagus: A Possible Unusual Paraneoplastic SyndromeTriple association : Glomérulonéphrite extramembraneuse, adénocarcinome rénal et hamartome splénique. À propos d'un casMembranous Glomerulonephritis and Malignancy 1 September 1985Volume 103, Issue 3Page: 474-474KeywordsAnklesDysphagiaEdemaEsophageal cancerEsophagusFoodGlomerulonephritisInflammationLesions ePublished: 1 December 2008 Issue Published: 1 September 1985 PDF downloadLoading ...
Glucosylceramide accumulates preferentially in lamellar bodies in differentiated keratinocytes
Authors: S. Hamanaka, S. Nakazawa, M. Yamanaka, Y. Uchida, F. Otsuka
Journal: British Journal of Dermatology (2005)

Background Sphingolipids, e.g. ceramide (Cer), glucosylceramide (GlcCer) and sphingomyelin (SM), are important bulk constituents of plasma membranes in mammalian cells. In addition, these lipids are also enriched in certain intracellular organelles, as well as in the epidermal lamellar bodies (LBs) of differentiating keratinocytes (KCs). Epidermal Cer, which comprises a heterogeneous family of at least 10 members, is a key component of the stratum corneum (SC) lipids, and regulates permeability barrier function. Levels of GlcCer, but not SM, significantly increase during epidermal differentiation, and then both GlcCer and SM are enzymatically hydrolysed to Cer at and just above the transition from the stratum granulosum to the SC. Objectives To determine: (i) whether the GlcCer contained in different pools, i.e. the membrane fraction or the LB fraction, has different metabolic fates; and (ii) whether specific molecular species of GlcCer localize to distinct subcellular pools. Methods To study the metabolic fate of specific molecular fractions of GlcCer and Cer, we first ascertained the full spectrum of molecular species present in cultured normal human KCs (CHK) in a differentiated condition as shown in vivo in epidermis. Cer species were analysed in CHK using matrix-assisted laser desorption/ionization time-of-flight mass spectrometry. Next, the metabolic fate of the GlcCer was studied by pulse-labelling of CHK with L-[14C]-serine. Results The GlcCer of undifferentiated KCs comprised GlcCer B and Cer NS (or Cer 2), which contain nonhydroxy fatty acid (FA) as the amide-linked FA, while differentiated KCs displayed further heterogeneity of both GlcCer and Cer, including the presence of acylGlcCer and acylCer. The metabolic fates of these sphingolipids were determined. The GlcCer B level decreased over 2 days and then plateaued between days 3 and 5 following pulse-labelling of sphingolipids for 24 h. As GlcCer B declined, Cer NS (Cer 2) increased in a similar time-dependent manner. In contrast, both acylGlcCer and acylCer increased continuously in parallel over this experimental period. Conclusions Distinct GlcCer pools segregated to those that were either hydrolysable or nonhydrolysable in differentiated KCs. We assume that the latter pool appears to be LB enriched, and also sequestrates acylGlcCer from other cellular membrane fractions.
Formation and reactions of negative ions relevant to chemical ionization mass spectrometry. I. Cl mass spectra of organic compounds produced by F <sup>−</sup> reactions
Authors: T. O. Tiernan, C. Chang, C. C. Cheng
Journal: Environmental Health Perspectives (1980)

A systematic study of the negative-ion chemical ionization mass spectra produced by the reaction of F− with a wide variety of organic compounds has been accomplished. A time-of-flight mass spectrometer fitted with a modified high pressure ion source was employed for these experiments. The F− reagent ion was generated from CF3H or NF3, typically at an ion source pressure of 100 μm. In pure NF3, F− is the major ion formed and constitutes more than 90% of the total ion intensity. While F− is also the major primary ion formed in pure CF3H, it undergoes rapid ion-molecule reactions at elevated source pressures, yielding (HF)nF− (n = 1−3) ions, which makes CF3H less suitable as a chemical ionization reagent gas. Among the organic compounds investigated were carboxylic acids, ketones, aldehydes, esters, alcohols, phenols, halides, nitriles, nitrobenzene, ethers, amines and hydrocarbons. An intense (M − 1)− ion was observed in the F− chemical ionization mass spectra of carboxylic acids, ketones, aldehydes and phenols. Alcohols yield only (M + F)− ions upon reaction with F−. A weaker (M + F)− ion was also detected in the F− chemical ionization spectra of carboxylic acids, aldehydes, ketones and nitriles. The F− chemical ionization mass spectra of esters, halides, nitriles, nitrobenzene and ethers are characterized primarily by the ions, RCOO−, X−, CN−, NO2−, and OR−, respectively. In addition, esters show a very weak (M − 1)− ion (except formates). In the F− chemical ionization spectra of some aliphatic alkanes and o-xylene, a very weak (M + F)− ion was observed. Amines and aliphatic alkenes exhibit only insignificant fragment ions under similar conditions, while aromatic hydrocarbons, such as benzene and toluene are not reactive at all with the F− ion. The mechanisms of the various reactions mentioned are discussed, and several experimental complications are noted. In still other studies, the effects of varying several experimental parameters, including source pressure, relative proportions of the reagent and analyte, and other ion source parameters, on the observed chemical ionization mass spectra were also investigated. In a mixture of NF3 and n-butanol, for example, the ratio of the intensities of the ions characteristic of the alcohol to that of the (HF)nF− ion was found to decrease with increasing sample pressure, with increasing NF3 pressure, and with increasing electron energy. No significant effects on the spectra were observed to result from variation of the source repeller field or the source temperature. The addition of argon to the source as a potential moderator did not alter the F− chemical ionization spectrum significantly, but the use of oxygen appears to inhibit formation of the (HF)nF− cluster ion. The advantages of using F− as a chemical ionization reagent are discussed, and comparisons are made with other reagent ions.
Cowboys Ain't Milkboys-Reply
Authors: Relda E. Niederhofer
Journal: JAMA (1986)

<h3>In Reply.—</h3> I appreciated Dr Churchill's comments about my article. Dr Churchill indicated that<i>Eupatorium rugosum</i>Houtt has been changed to<i>Ageratina altissima</i>R. M. King and H. Rob. The scientific name for the Midwestern white snakeroot has undergone several changes since it was first identified. The articles I reviewed showed that white snakeroot<i>Eupatorium urticaefolium</i>was named<i>Eupatorium ageratoides</i>in the earlier literature. In 1938, E. D. Merrill<sup>1</sup>reported three binomials:<i>Eupatorium rugosum</i>Maarten Houttuyn,<i>Natuurlijke Historie II</i>, x (part 10) page 558 (1779);<i>Eupatorium urticaefolium</i>D. Joanne Jacobo Reichard,<i>Systema Plantarum</i>iii (part 3), page 719 (1780); and<i>Eupatorium ageratoides</i>Carl von Linne, filius,<i>Supplementum Plantarum</i>, page 355 (1781). All three taxonomists proposed new names for the same species, one year apart. Merrill's choice of the oldest published name,<i>Eupatorium rugosum</i>Houtt, based on<i>Ageratum altissimum</i>Linn, followed the principle of priority, adopted by the International Botanical
Modified Masaoka Stage and Size Are Independent Prognostic Predictors in Thymoma and Modified Masaoka Stage Is Superior to Histopathologic Classifications
Authors: Anja C. Roden, Eunhee S. Yi, Sarah M. Jenkins, Kelly K. Edwards, Janis L. Donovan, Stephen D. Cassivi, Randolph S. Marks, Yolanda I. Garces, Marie Christine Aubry
Journal: Journal of Thoracic Oncology (2015)
Inhibition of an IgE response by secondary B cells of a different isotype.
Authors: S Haba, M F Gurish, A Nisonoff
Journal: The Journal of Experimental Medicine (1986)

We found that the synthesis of IgE anti-Ars antibodies is strongly inhibited by the presence of secondary non-IgE-producing cells that are specific for the Ars hapten. Such B cells can be induced by inoculation of a protein-Ars conjugate in CFA. The effect is seen after inoculation of OVA-Ars in CFA followed by KLH-Ars in alum, or, more convincingly, after adoptive transfer of B cells induced by antigen in CFA. Dose-response data indicated that inhibition can be effected by B cells containing noninhibitory numbers of contaminating T cells. Possible synergistic effects of carrier-specific regulatory T cells were ruled out by using a different protein carrier for immunization of donor and recipient mice. The effect was shown to be specific for the hapten used for immunization of donor mice.
Body Mass and Hypertension in Women
Authors: Allison Oler
Journal: Annals of Internal Medicine (1998)

Letters1 July 1998Body Mass and Hypertension in WomenAllison Oler, MD and Philippe Szapary, MDAllison Oler, MDUniversity of Pennsylvania; Philadelphia, PA 19104Search for more papers by this author and Philippe Szapary, MDUniversity of Pennsylvania; Philadelphia, PA 19104Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-129-1-199807010-00020 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:Huang and colleagues' article on body weight, weight change, and risk for hypertension produced a convincing and unsurprising conclusion that both excess body mass and weight gain in adult women were associated with a linear increased risk for hypertension [1]. Two related issues that they did not discuss in the article would be interesting to address.First, in the United States, it has been estimated that 44% of African-American women meet criteria for obesity (body mass index ≥ 27 kg/m2), compared with 24% of white women [2]. The prevalence of hypertension among African-American women has also been ...References1. Huang Z, Willett WC, Manson JE, Rosner B, Stampfer MJ, Speizer FE, et al. Body weight, weight change, and risk for hypertension in women. Ann Intern Med. 1998; 128:81-8. Google Scholar2. Kumanyika SK. Special issues regarding obesity in minority populations. Ann Intern Med. 1993; 119(7 pt 2):650-4. Google Scholar3. Cooper R, Rotimi C. Hypertension in blacks. Am J Hypertens. 1997; 10(7 pt 1):804-12. Google Scholar4. Lissner L, Bengtsson C, Lapidus L, Larsson B, Bengtsson B, Brownell K. Body weight variability and mortality in the Gothenburg prospective studies of men and women. In: Bjorntorp P, Rossner S, eds. Obesity in Europe 88. Proceedings of the First European Congress on Obesity. London: John Libbey; 1989:55-60. Google Scholar5. Lissner L, Odell PM, D'Agostino RB, Stokes J 3d, Kreger BE, Belanger AJ, et al. Variability of body weight and health outcomes in the Framingham population. N Engl J Med. 1991; 324:1839-44. Google Scholar Author, Article, and Disclosure InformationAffiliations: University of Pennsylvania; Philadelphia, PA 19104 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 July 1998Volume 129, Issue 1Page: 71KeywordsBody weightDietHypertensionObesityProspective studiesRacial and ethnic issuesRelative riskRisk managementWeight gainWeight loss Issue Published: 1 July 1998 Copyright & PermissionsCopyright © 1998 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
True power dissipation of catheter tip velocity probes
Authors: J. W. BUCHANAN, R. SHABETAI
Journal: Cardiovascular Research (1972)

Journal Article True power dissipation of catheter tip velocity probes Get access JACK W. BUCHANAN, JR., JACK W. BUCHANAN, JR. From the Cardiovascular Division, Department of Medicine, University of Kentucky College of Medicine, Lexington, Kentucky 40506, U.S.A. Search for other works by this author on: Oxford Academic PubMed Google Scholar RALPH SHABETAI RALPH SHABETAI From the Cardiovascular Division, Department of Medicine, University of Kentucky College of Medicine, Lexington, Kentucky 40506, U.S.A. Search for other works by this author on: Oxford Academic PubMed Google Scholar Cardiovascular Research, Volume 6, Issue 2, March 1972, Pages 211–213, https://doi.org/10.1093/cvr/6.2.211 Published: 01 March 1972
Successful Treatment of Langerhans'-Cell Histiocytosis with Etanercept
Authors: Jan-Inge Henter, Jonas Karlén, Ulrika Calming, Cecilia Bernstrand, Ulf Andersson, Bengt Fadeel
Journal: New England Journal of Medicine (2001)

To the Editor: Langerhans'-cell histiocytosis, previously called histiocytosis X, is an accumulation of dendritic Langerhans' cells and granulomatous lesions in various organs; its cause is unknown...
KIDNEY FUNCTION IN MORPHINE ADDICTS
Authors: ROBERT S. ACKERLY
Journal: JAMA (1930)

The controversy over the effect of morphine on kidney function has long been unsettled and many physicians, particularly genito-urinary surgeons, are loath to give the drug even for severe pain, fearing that it will increase the dysfunction in an already impaired kidney. If their fears can be dispelled, their patients will derive the benefits of rest with minimized postoperative pain to aid in their recovery. Slocum's<sup>1</sup>questionnaire brought out the conflicting opinions of surgeons generally. Ten per cent of the surgeons answering the question "Does morphine have a deleterious action on the kidney?" replied in the affirmative but did not explain why it was harmful, and 85 per cent answered in the negative. The article by Haines and Milliken<sup>2</sup>and that of Davis<sup>3</sup>showed not only that morphine might be used without fear of injuring the kidney but that morphine and atropine even accelerated and improved kidney
Long-Term Leptin-Replacement Therapy for Lipoatrophic Diabetes
Authors: Ken Ebihara, Hiroaki Masuzaki, Kazuwa Nakao
Journal: New England Journal of Medicine (2004)

and Decherd do not provide robust outcome data on the procedures they advocate.I consider an average fee of more than $5,000 for an operation lasting several hours to be expensive and profitable. 1 The experience of a mystery shopper who consulted five established plastic surgeons with the same requests illustrates the lack of consensus among cosmetic surgeons about optimal therapy. 2 Both the recommended treatments and their costs ($2,900 to $14,150) varied greatly among the surgeons.Given the lack of good studies quantifying the benefits and risks of many of the cosmetic procedures and products that leading plastic sur-geons now advocate and sell, and given the even scantier information on individual surgeons' outcomes, I hope the American Society of Plastic Surgeons will take a leading role in filling this void in the data.
Numbers needed to treat and harm
Authors: P. Sedgwick
Journal: BMJ (2010)

The effects of statins in people aged between 30 and 84 years were investigated using a prospective cohort study.1 Data were taken from the QResearch database, a computerised database of anonymised longitudinal medical records collected prospectively in primary care. A cohort of patients registered with general practices between 1 January 2002 and 30 June 2008 was used. New users of statins were compared with non-users. The intended effect of statins was a reduction in the occurrence of cardiovascular disease. The number needed to treat for cardiovascular disease over five years was 37 (95% confidence interval 27 to 64) for women and 33 (95% CI 24 to 57) for men. Acute renal failure was a side effect of statins: the number needed to harm was 434 (95% CI 284 to 783) for women and 593 (95% CI 388 to 1070) for men. Which of the following statements, if any, are true?
Helical atheractomy for in-stent restenosis: acute and long-term results from the helixcision™ endoluminal in-stent excision (HELIX 1) international feasibility trial
Authors: Mamoo Nakamura, Andrew J. Carter, Yasuhiro Honda, Alexander Abizaid, Arne Tofte, Eberhard Grube, Paul G. Yock, Alan C. Young, Peter J. Fitzgerald
Journal: Journal of the American College of Cardiology (2002)