PERICARDIAL EFFUSION ASSOCIATED WITH MYXEDEMA
Authors: P A MARKS, B S ROOF
Journal: Annals of Internal Medicine (1953)

Article1 August 1953PERICARDIAL EFFUSION ASSOCIATED WITH MYXEDEMAPAUL A. MARKS, M.D., BETTY S. ROOF, M.D.PAUL A. MARKS, M.D., BETTY S. ROOF, M.D.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-39-2-230 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptINTRODUCTION"Myxedema heart" was first described as a clinical entity by Zondek1 in 1918. His description of the abnormal findings in patients with myxedema included enlargement of the heart, feeble cardiac pulsations, slow heart rate, normal blood pressure and reduced voltage in the electrocardiogram. These changes were found to be completely reversible upon treatment with thyroid hormone. Since this initial report there have been numerous observations2-8 confirming Zondek's findings.The nature of the pathologic changes accounting for these cardiac disturbances has been a matter of some disagreement in the literature. The suggested changes include cardiac dilatation, fibrosis of the myocardium,...Bibliography1. Zondek H: Das Myxödemherz, München. med. Wchnschr. 65: 1180, 1918. Google Scholar2. AymanRosenblumFalcon-Lesses DHM: "Myxedema heart" without evidence of cardiac insufficiency, J. A. M. A. 98: 1721, 1932. CrossrefGoogle Scholar3. Fahr G: Myxedema heart, J. A. M. A. 84: 345, 1925. CrossrefGoogle Scholar4. Holzman JE: Myxedema heart with report of two cases, Am. Heart J. 4: 351, 1928-29. CrossrefGoogle Scholar5. LermanClarkMeans JRJJH: The heart in myxedema, Ann. Int. Med. 6: 1251, 1933. LinkGoogle Scholar6. OhlerAbramson WRJ: The heart in myxedema, Arch. Int. Med. 53: 165, 1934. CrossrefGoogle Scholar7. CapriglioneSchermannSchlesingerBenchimol LJPAB: O carocao no mixedema, Arq. clin. 11: 225, 1950. MedlineGoogle Scholar8. McGavackLangeSchwimmer THKD: Management of the myxedematous patient with symptoms of cardiovascular disease, Am. Heart J. 29: 421, 1945. CrossrefGoogle Scholar9. La Due JS: Myxedema heart: a pathological and therapeutic study, Ann. Int. Med. 18: 332, 1943. LinkGoogle Scholar10. Cabot RC: Case Records of the Massachusetts General Hospital, Case No. 14411, New England J. Med. 199: 1106, 1928. CrossrefGoogle Scholar11. BehrMueder EJ: Het Myxoedeemhart, Nederl. tijdschr. v. Geneesk. 82: 4303, 1938. Google Scholar12. Schultz A: Über einen Fall von Athyreosis congenita (Myxödem) mit besonderer Berücksichtigung der dabei beobachteten Muskelveränderungen, Virchows Arch. f. path. Anat. 232: 302-315, 1921. CrossrefGoogle Scholar13. Yener MS: Miksodemelilerde Perikard Epansumani (pericardial effusion myxedema), Türk tib cem. mec. 17: 135, 1951 (summary in English). MedlineGoogle Scholar14. SchnitzerGutmann RD: Myxedema with pericardial effusion, Brit. Heart J. 8: 25, 1946. CrossrefGoogle Scholar15. MarzulloFranco ERS: Myxedema with multiple serous effusions and cardiac involvement (myxedema heart), Am. Heart J. 17: 368, 1939. CrossrefGoogle Scholar16. Schmidt S: L'epanchement pericardeque dans le myxedéme, J. de radiol. et d'électrol. 31: 428, 1950. MedlineGoogle Scholar17. HarrellJohnston GTC: Pericardial effusion in myxedema, Am. Heart J. 25: 505, 1943. CrossrefGoogle Scholar18. GarcinLenegieWeltiSalet RJJJJ: Cardiomegalie et pericardite dans le myxoedeme, Bull. et mém. Soc. méd. d. hôp. de Paris 58: 146, 1942. Google Scholar19. BullrichRepettoFerrari RARJA: Derrame pericardio mixedematoso taponamento cardiaco cronico, Prensa méd. argent. 31: 2423, 1944. Google Scholar20. Musso-FournierCervinoBazzano JCJMJJ: Myxedematous dropsy—report on a case of myxedema with congestive heart failure and serous effusions with a high protein content, J. Clin. Endocrinol. 6: 758, 1946. CrossrefGoogle Scholar21. KernSoloffSnapeBello RALAWJCT: Pericardial effusion: a constant, early and major factor in myxedema heart, Am. J. M. Sc. 217: 609, 1949. CrossrefMedlineGoogle Scholar22. Kaunitz H: Hydroperikard bei inkretorischer Störung, Ztschr. f. klin. Med. 130: 601, 1936. Google Scholar23. Boivin JM: Histoire d'un épanchement péricardique recidivant asséché par l'extrait thyroidien, Arch. d. mal. du cœur 38: 289, 1945. Google Scholar24. Feasby WR: Pericardial effusion in myxedema, Am. Heart J. 19: 749, 1940. CrossrefGoogle Scholar25. Freeman EB: Chronic pericardial effusion in myxedema, Ann. Int. Med. 7: 1070, 1934. LinkGoogle Scholar26. Waring JJ: The heart in myxedema, in Essays in Biology, 1943, University of California Press, Berkeley and Los Angeles, p. 611. Google Scholar27. Gordon AH: Pericardial effusion in myxedema, Tr. A. Am. Physicians 50: 272, 1935. Google Scholar28. Howard JW: Myxedema with cholesterosis and massive pericardial effusion, Delaware State M. J. 18: 150, 1946. MedlineGoogle Scholar29. SheifBoyd DL: Cardiovascular diseases, 1947, J. B. Lippincott Company, Philadelphia. Google Scholar30. MayNetterTiret EAJ: Les epanchement des séreuses dans le myxoedeme, Presse méd. 51: 199, 1943 (abstract). Google Scholar31. Vallery-RadotLenegreWelti PLJJ: La pericardite myxoedemateuse, Presse méd. 51: 210, 1943. Google Scholar32. GascardPierror EJ: Myxedematous pericarditis, Paris méd. 41: 3, 1951. Google Scholar33. CachinMaurice MP: Myxedematous pericarditis, Semaine d. hôp. Paris 26: 137, 1950. MedlineGoogle Scholar34. MarcaidoCarreno RBEP: Derrame pericardico en el corago mixedematoso, Rev. cubana de cardiol. 10: 205, 1949. Google Scholar35. Friedberg CK: Diseases of the heart, 1949, W. B. Saunders Company, Philadelphia, p. 939. Google Scholar36. StewartDeitrichCrane HJJENF: Studies of the circulation in patients suffering from spontaneous myxedema, J. Clin. Investigation 17: 237, 1938. CrossrefMedlineGoogle Scholar37. DaviesMacKinnonPlatts CEJMM: Renal circulation and cardiac output in "low output" heart failure and in myxedema, Brit. M. J. 2: 595, 1952. CrossrefMedlineGoogle Scholar38. Tatum AL: Morphological studies in experimental cretinism, J. Exper. Med. 17: 636, 1913. CrossrefMedlineGoogle Scholar39. WebsterCoohe BC: Morphological changes in the heart in experimental myxedema, Arch. Int. Med. 58: 269, 1936. CrossrefGoogle Scholar40. Goldberg SA: Changes in organs of thyroidectomized sheep and goats, Quart. J. Exper. Physiol. 17: 15, 1927. CrossrefGoogle Scholar41. Lange K: Capillary permeability in myxedema, Am. J. M. Sc. 208: 5, 1944. CrossrefGoogle Scholar42. WatsonPearce EMRH: The cutaneous mucopolysaccharides in localized (pre-tibial) myxedema, Ann. New York Acad. Sc. 52: 1004, 1950. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: New York, N. Y.*Received for publication February 10, 1953.From the Department of Medicine, College of Physicians and Surgeons, Columbia University, and the Presbyterian Hospital, New York, N. Y. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byHypothyroid cardiomyopathy: A reversible phenocopy of hypertrophic cardiomyopathyPleural EffusionPleura and pleural disordersPleural EffusionCholesterol-Based Pericardial Effusion and Aortic Thromboembolism in a 9-Year-Old Mixed-Breed Dog with Hypothyroidism3 Clinical pathophysiology and metabolic effects of hypothyroidismProlonged persistence of a large pericardial effusion and hemodynamic evidence of cardiac tamponade during treatment of myxedemaCardiac tamponade in medical patients.Echocardiographic evaluation of pericardial effusion in myxedema. Incidence and biochemical and clinical correlations.EFFUSIONS INTO BODY CAVITIES IN HYPOTHYROIDISMChanges in the Electrocardiogram and Achilles Reflex Test during Treatment of HypothyroidismSerum lactic dehydrogenase isoenzymes in "myxoedema heart disease".Cholesterol pericarditisCardiomegaly in myxedemaThe heart in hypothyroidismTHE ELECTROCARDIOGRAM IN MYXOEDEMAMYXŒDEMA AND HEART-FAILUREMediastinal Effusions in a Case of Pituitary MyxedemaThe heart in hypothyroidismHypothyreosen — Strumen — ThyreoiditidenThe Current Status of Procaine Amide in the Management of Cardiac ArrhythmiasErkrankungen des PerikardHerz und Kreislauf bei Störungen der SchilddrüsenfunktionHerz und Kreislauf bei Störungen der SchilddrüsenfunktionElectrocardiographic changes in hypopituitarism of pregnancyDas Herz bei Myxödem und HypothyreosePhysiology and treatment of myxedemaKrankheiten der Schilddrüse 1 August 1953Volume 39, Issue 2Page: 230-240KeywordsBlood pressureElectrocardiographyFibrosisHeartHeart rateHospital medicineMyocardiumSurgeonsThyroid hormones ePublished: 1 December 2008 Issue Published: 1 August 1953 PDF downloadLoading ...