tbuckley/cabot-search huggingface dataset:
New Kidney Function Test
Authors: Tracy Hampton
Journal: JAMA (2005)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Abstract 2488: Can an Elderly Woman's Heart be too Strong? Increased Mortality with High vs. Normal Ejection Fraction after an Acute Coronary Syndrome. The Global Registry of Acute Coronary Events
Authors: Fadi A Saab, Philippe Gabriel Steg, Alvaro Avezum, Dante Pazzanese, Jose Lopez-Sendon, Frederick A Anderson, Wei Huang, Kim A Eagle
Journal: Circulation (2006)
Abstract 11656: Ranolazine Improves Cardiovascular-and Diabetes-Related Healthcare Utilization in Patients With Chronic Stable Angina and Co-Morbid Diabetes
Authors: Robert L Page, Vahram Ghushchyan, Richard A Allen, Cynthia L Hartsfield, Bruce R Koch, Kavita V Nair
Journal: Circulation (2014)

Introduction: Ranolazine(RAN) may improve cardiovascular (CV) and diabetes (DM) healthcare utilization and outcomes in patients with chronic stable angina (CSA) and DM. Methods: Medical, pharmacy claims linked with laboratory data from 2008-2012 were analyzed using a commercial database. Patients with CSA receiving RAN, beta blocker (BB),calcium channel blocker (CCB), or long-acting nitrate (nitrate), along with sublingual nitroglycerin were identified and followed for 12 months after antianginal therapy change. Therapy change was defined as adding or switching to another antianginal or RAN (index date) following previous therapy. Four CSA groups were identified (BB, CCB, nitrates,RAN) and propensity matched based on baseline age, gender, chronic condition index, ACS, hypertension, DM, heart failure, hyperlipidemia, DM related complications, and CV costs. A subset of patients with DM represented the study groups. Logistic regression models were developed comparing revascularization at 30, 60, 90, 180 and 360 days between groups. Negative binomial regression was used to compare CV and DM related healthcare utilization. Descriptive differences in HbA1C levels pre and post therapy change were reported. Results: 3724 patients were identified (BB, n=933;CCB,n=940; nitrates,n=937, RAN, n=914). Majority (61-65%) were male with a mean age of 66-67 years. Compared to other antianginals, RAN exhibited significantly lower odds for revascularization at all time periods, a lower rate for CV related outpatient and ER visits, and a reduced expected rate of DM related inpatient length of stay (Table). RAN was associated with a mean HbA1C reduction of 0.20 mg/dl compared to the BB (0.14 mg/dl increase, p=0.028), CCB (0.21 mg/dl increase, p=0.005), and nitrate (0.05 mg/dl decrease, p=0.277) cohorts. Conclusion: RAN demonstrated lower CV and DM healthcare utilization compared to traditional antianginals, while not worsening glycemic control vs. BB and CCB.
Abstract 269: Extracorporeal Cardiopulmonary Resuscitation Can Bring a Better Outcome of Out-of-Hospital Cardiac Arrest With Shockable Rhythm Than Conventional CPR: An Interim Report From "Study of Advanced Life Support for Ventricular Fibrillation With Extracorporeal Circulation in Japan "(SAVE-J) Study Group
Authors: Tetsuya Sakamoto, Yasufumi Asai, Ken Nagao, Hiroyuki Yokota, Yoshio Tahara, Naoto Morimura, Takahiro Atsumi, Mamoru Hase, Satoshi Nara
Journal: Circulation (2010)

Background: An objective of this study is to examine the efficacy of extracorporeal cardiopulmonary resuscitation (ECPR) for patients in out-of hospital cardiac arrest (OHCA) with shockable rhythm ...
Abstract 1470: Endothelial Specific Overexpression of the L-Arginine Transporter, CAT1, Augments Nitric Oxide Production and Endothelial Function
Authors: Zhiyong Yang, Emma Jones, Kylie Venardos, Jaye Chin-Dusting, David M. Kaye
Journal: Circulation (2006)

Background: Endothelial dysfunction due to reduced nitric oxide (NO) bioavailability is a fundamental feature of a number of cardiovascular disorders and their associated risk factor states. Severa...
Abstract 19772: The Significance of Blood Pressure on Cardiovascular Risk Attributable to Diabetes
Authors: Ryosuke Komi, Fumitaka Tanaka, Shinji Makita, Toshiyuki Onoda, Kozo Tanno, Masaki Ohsawa, Kazuyoshi Itai, Kiyomi Sakata, Shin-iti Omama, Kuniaki Ogasawara, Yasuhiro Ishibashi, Akira Okayama, Motoyuki Nakamura
Journal: Circulation (2014)

Background: Diabetes mellitus (DM) is an established risk factor of atherosclerotic cardiovascular events (CVE). Individuals with DM often have elevated levels of blood pressure (BP) which is closely associated with CVE.

Hypothesis: The risk of DM-related CVE may depend on BP levels.

Methods: A population-based prospective cohort study was performed in 24,350 subjects aged 40 to 89 years (mean age = 63.0±10.0 years) who did not have a history of CVE. DM was defined as a casual blood glucose level ≥ 200 mg/dl or fasting blood glucose level ≥ 126 mg/dl, a glycated hemoglobin value ≥ 6.5%, and/or current anti-diabetic therapy. BP levels at the baseline examination were classified into three categories including normotension, pre-hypertension, and hypertension according to JNC7. This classification was applied also to subjects with antihypertensive agents use. After adjustment for age, sex, body mass index, eGFR, total and HDL cholesterol, smoking habits, and anti-hypertensive medication use, a multivariate Cox regression analysis was performed to examine an association and contribution of pre-hypertension and hypertension on the risk of CVE in DM and non DM.

Results: During a mean follow-up period of 5.5 years, 746 subjects developed CVE which was defined as stroke or acute myocardial infarction/sudden cardiac death. In both DM and non DM, the hazard ratios for CVE were increased in pre-hypertensives (HR 1.25, p < 0.05; HR 2.59, p < 0.02, respectively) and in hypertensives (HR 1.82, p < 0.01; HR 3.66, p < 0.01, respectively) in comparison with normotensives. However, the population-attributable fractions (PAFs) of pre-hypertension and hypertension were apparently higher in DM (21.5%, 41.2%, respectively), as these were more than double compared to PAFs in non DM (6.7%, 20.3%, respectively).

Conclusions: Approximately two-third of excess CVE attributable to DM is estimated to occur among individuals with elevated BP levels.

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Abstract 15537: Morphological Characteristics of Culprit Ruptured Plaques Differ Between NSTEMI and STEMI
Authors: Konstantinos Toutouzas, Antonios Karanasos, Eleftherios Tsiamis, Maria Riga, Maria Drakopoulou, Andreas Synetos, Aggelos Papanikolaou, George Latsios, Dimitrios Tousoulis, Christodoulos Stefanadis
Journal: Circulation (2011)

Purpose: Plaque rupture is a common trigger in the pathogenesis of non-ST-elevation myocardial infarction (NSTEMI) and ST-elevation myocardial infarction (STEMI). However, the association between t...
Novel chromatographic process for the purification of recombinant adeno-associated virus pseudotypes
Authors: Michael Moxley, Donald Fisher, Anthony P. Green, Timothy D. Kierstead
Journal: Molecular Therapy (2004)

Recombinant Adeno-Associated Virus (AAV) is an important vector for efficient gene transfer. AAV generates minimal immune responses and recombination of surface capsid proteins to generate pseudotypes has allowed for the development of more efficient tissue targeting. However, purification processes applicable to multiple AAV pseudotypes presents a challenge and is only now being addressed. Conventional gradient methods using CsCl are cumbersome, difficult to scale and will not meet the anticipated needs for pre-clinical and clinical trials. First generation chromatographic processes are typically based on anion-exchange chromatography and also have limitations.
Mitral Apparatus Assessment by Delayed Enhancement CMR
Authors: Jason S. Chinitz, Debbie Chen, Parag Goyal, Sean Wilson, Fahmida Islam, Thanh Nguyen, Yi Wang, Sandra Hurtado-Rua, Lauren Simprini, Matthew Cham, Robert A. Levine, Richard B. Devereux, Jonathan W. Weinsaft
Journal: JACC. Cardiovascular imaging (2013)
The gene encoding a newly discovered protein, chorein, is mutated in chorea-acanthocytosis
Authors: Shu-ichi Ueno, Yoshiko Maruki, Masayuki Nakamura, Yuko Tomemori, Kazue Kamae, Hirotaka Tanabe, Yoriaki Yamashita, Seiji Matsuda, Sunao Kaneko, Akira Sano
Journal: Nature Genetics (2001)
Task Force 1: The ACCF and AHA codes of conduct in human subjects research
Authors: Joseph S. Alpert, Kenneth I. Shine, Robert J. Adams, Elliott M. Antman, Rae Ellen W. Kavey, Lawrence Friedman, Robert L. Frye, Robert A. Harrington, David Korn, Jon F. Merz, Elizabeth Ofili
Journal: Journal of the American College of Cardiology (2004)
Lesson of the week: Unnecessary surgical treatment of fungal kerions in children
Authors: K. L Gibbon
Journal: BMJ (2000)

Children with suspected kerion or scalp abscess should be assessed first by a dermatologist 

The incidence of tinea capitis in children living in inner cities in the United Kingdom is rising and is reaching epidemic proportions in London. The organism responsible for the infection is also changing. There has been a dramatic increase in infection with Trichophyton tonsurans , particularly among Asian and Afro-Caribbean patients. Fungal infections of the scalp can cause kerions—pus filled inflammatory swellings that may look like bacterial abscesses. Many children with scalp infections who present at accident and emergency departments are being triaged to surgical teams rather than dermatology units. We report two children who underwent incision and drainage of their kerions under local and general anaesthesia. This treatment was unnecessary and inappropriate and carried the risks associated with general anaesthesia and surgery. We recommend that children who present at emergency departments with boggy, pus filled swellings on the scalp should be seen first at dermatology units, where appropriate investigations and antifungal treatment can be instigated.

### Case 1

An 11 year old white boy presented to the accident and emergency department. He had had a scaly eruption affecting the right parietal area of the scalp for six weeks. He had been prescribed potent topical …
Myocardial Recovery Using Ventricular Assist Devices
Authors: Marc A. Simon, Robert L. Kormos, Srinivas Murali, Pradeep Nair, Michael Heffernan, John Gorcsan, Stephen Winowich, Dennis M. McNamara
Journal: Circulation (2005)

Background— Ventricular assist devices (VADs) are important bridges to cardiac transplantation. VAD support may also function as a bridge to ventricular recovery (BTR); however, clinical predictors of recovery and long-term outcomes remain uncertain. We examined the prevalence, characteristics, and outcomes of BTR subjects in a large single center series. Methods and Results— We implanted VADs in 154 adults at the University of Pittsburgh from 1996 through 2003. Of these implants, 10 were BTR. This included 2/80 (2.5%) ischemic patients (supported 42 and 61 days, respectively). Both subjects had surgical revascularization, required perioperative left VAD support, and were alive and transplant-free at follow up (232 and 1319 days, respectively). A larger percentage of nonischemic patients underwent BTR (8/74, 11%; age 30±14; 88% female; left ventricular ejection fraction 18±6%; supported 112±76 days). Three had myocarditis, 4 had post-partum cardiomyopathy (PPCM), and 1 had idiopathic cardiomyopathy. Five received biventricular support. After explantation, ventricular function declined in 2 PPCM patients who then required transplantation. Ventricular recovery in the 6 nonischemic patients surviving transplant-free was maintained (left ventricular ejection fraction 54±5%; follow-up 1.5±0.9 years). Overall, 8 of 10 BTR patients are alive and free of transplant (follow-up 1.6±1.1 years). Conclusions— In a large single center series, BTR was evident in 11% of nonischemic patients, and the need for biventricular support did not preclude recovery. For most BTR subjects presenting with acute inflammatory cardiomyopathy, ventricular recovery was maintained long-term. VAD support as BTR should be considered in the care of acute myocarditis and PPCM.
Isolated corticotropin deficiency in chronic alcoholism
Authors: T Kearney, S Robinson, D G Johnston
Journal: Journal of the Royal Society of Medicine (2000)

Summary Three patients who chronically abused alcohol were found to be hyponatraemic with normal plasma potassium. The first had been admitted with confusion and weight loss, the second with hypotension and sepsis, and the third with confusion and hypoglycaemia-induced seizures. All three patients had a subnormal cortisol response in the short synacthen test; however, the plasma cortisol after three days of tetracosactrin administration was greater than 550 nmol/L. Baseline corticotropin levels were less than 10 pg/mL in all three. No structural lesions of the hypothalamo-pituitary tract were found and there was no evidence of other endocrinopathies. Glucocorticoid replacement therapy led to the resolution of hyponatraemia and hypoglycaemia, where present, and to clinical improvement. The two surviving patients remained hypocortisolaemic in the long term, without recurrence of hyponatraemia or hypoglycaemia. The features of isolated corticotropin deficiency are easily confused with other effects of chronic alcohol abuse. In alcoholic patients with unexplained hyponatraemia, hypoglycaemia or haemodynamic instability, a short tetracosactrin test is advisable.
Facing Our Morality
Authors: D Loxterkamp
Journal: JAMA (1999)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
A New Subtype of Large B-Cell Lymphoma Expressing the ALK Kinase and Lacking the 2; 5 Translocation
Authors: Georges Delsol, Laurence Lamant, Bernard Mariamé, Karen Pulford, Nicole Dastugue, Pierre Brousset, Françoise Rigal-Huguet, Talal Al Saati, Douglas Pat Cerretti, Stephan W. Morris, David Y. Mason
Journal: Blood (1997)
Neuropharmacological agents modifying endotoxin-induced changes in mice
Authors: David J M Wright, Malcolm P I Weller
Journal: Journal of the Royal Society of Medicine (1980)

A variety of neuropharmacological agents were tested to elucidate how chlorpromazine influenced an endotoxin-induced reaction. The results obtained, particularly with beta-adrenergic blocking agents, reserpine and fusaric acid, suggested that the primary locus of chlorpromazine's action was mediated by peripheral beta-adrenergic receptor blockade. Such a locus is compatible with the low doses of propranolol which suppress the reaction, and with successful treatment of shock with dopamine.
Abstract #5566: NKTR-105 demonstrates superior antitumor activity over docetaxel in a NSCLC mouse xenograft model and increases tumor docetaxel exposure
Authors: Ute Hoch, Renee Hartsook, Heather Persson, Aleksandrs Odinecs, Yuan Song, Wen Zhang, Antoni Kozlowski, Ron Wolff
Journal: Cancer Research (2009)

AACR Annual Meeting-- Apr 18-22, 2009; Denver, CO

NKTR-105, a novel multi-arm PEGylated docetaxel conjugate, is entering phase 1 development in patients with refractory solid malignancies. In nonclinical studies, NKTR-105 demonstrated superior activity over docetaxel in several mouse models of human cancer. To assess whether the improved antitumor activity is due to greater plasma and tumor docetaxel exposure following NKTR-105 administration, we analyzed plasma and tumor homogenates after a single IV administration of NKTR-105 or docetaxel in mice bearing H460 tumors. NKTR-105 and docetaxel were dosed at respective maximum tolerated doses (MTDs) of 33 and 25 mg/kg. After NKTR-105 administration, plasma docetaxel concentrations were sustained above 5 ng/mL for as long as 168 hr, whereas docetaxel concentrations fell below 1 ng/mL by 72 hr after docetaxel administration. Despite administering a 32% higher dose, the plasma docetaxel Cmax with NKTR-105 was 13-fold lower than that with docetaxel. While both treatments achieved a similar plasma docetaxel area under the concentration-time curve (AUC), NKTR-105 treatment resulted in tumor docetaxel concentrations that were 0.4 to 4-fold higher than those for docetaxel, leading to a 2-fold greater tumor docetaxel AUC. At equitoxic doses, this greater and sustained tumor exposure to docetaxel after NKTR-105 administration was associated with significantly longer tumor growth delay over docetaxel (122% vs 48%). NKTR-105 retained significant antitumor activity at 19 mg/kg (58% of its MTD), whereas docetaxel doses less than 25 mg/kg did not.$$table_{6768386D-27E1-4C1B-87FA-30297B260528}$$ This comparative study indicates that the superior antitumor activity of NKTR-105 is mediated by greater and sustained tumor docetaxel exposure. The encouraging antitumor activity and unique pharmacokinetic profile of NKTR-105 in nonclinical studies warrants advancement of this novel drug candidate into clinical trials.

Citation Information: In: Proc Am Assoc Cancer Res; 2009 Apr 18-22; Denver, CO. Philadelphia (PA): AACR; 2009. Abstract nr 5566.
New nomenclature for MHC receptors
Authors: P. André, R. Biassoni, M. Colonna, D. Cosman, L. L. Lanier, E. O. Long, M. Lopez-Botet, A. Moretta, L. Moretta, P. Parham, J. Trowsdale, E. Vivier, N. Wagtmann, M. J. Wilson
Journal: Nature Immunology (2001)
Drug trials still fail to include sufficient numbers of women
Authors: Deborah Josefson
Journal: BMJ (2001)

Efforts to limit sex bias in clinical drug trials have improved but are still inadequate, says a follow up report on the drug approval practices of the United States' Food and Drug Administration (FDA), issued by the General Accounting Office.

The General Accounting Office is the investigative arm of the US Congress. In 1992 it found that not enough women were included in pre-approval clinical trials of drugs and charged the FDA with the task of improving …
Looking forward: The NHS: feeling well and thriving at 75
Authors: D. M Berwick
Journal: BMJ (1998)

This article is based on a talk given to “The NHS: All our tomorrows,” the 50th anniversary of the NHS conference, London, 1 July 1998

It is a thrill and an honour to welcome you to the 75th anniversary celebration of the NHS. Time flies. It seems only moments ago that many of us here were assembled in 1998 for the glorious 50th anniversary celebration. That meeting, at the close of the last millenium, marked, as you know, a turning point for the NHS. We recognised and celebrated the achievements of the last half of the 20th century, but we also set the stage for the enormous leaps that we have made in the 25 years since.

A lot has changed since 1998. Who could then have anticipated that durable peace would finally settle not only on Ireland but also on the Middle East and the Balkan states? We could not then have known for sure that measles would now be eradicated, river blindness brought under control, and the worldwide epidemic of multidrug resistant tuberculosis stopped through unprecedented international public health collaboration. In the United States, where health care costs reached 22% of the gross domestic product in 2015, real reform finally took hold, beginning with President Whoopie Goldberg's famous call, paraphrasing Ian Morrison, that the United States become, “At last a nation where health care is a right and carrying a semiautomatic machine gun is a privilege, instead of the other way round.” Today American health care is administered under a single, government sponsored insurance scheme, with public accountability not at all dissimilar to the NHS. For the first time in nearly a century, American healthcare costs are falling (they are now only 50% higher than Britain's), the population's health is improving, and all Americans can get the care …
Indocyanine green-augmented diode laser treatment of port-wine stains: clinical and histological evidence for a new treatment option from a randomized controlled trial
Authors: A. Klein, R.-M. Szeimies, W. Bäumler, F. Zeman, S. Schreml, U. Hohenleutner, M. Landthaler, M. Koller, P. Babilas
Journal: British Journal of Dermatology (2012)

Complete clearance of port-wine stains (PWS) is difficult to achieve, mainly because of the resistance of small blood vessels to laser irradiation. Indocyanine green (ICG)-augmented diode laser treatment (ICG+DL) may overcome this problem.To evaluate the feasibility of ICG+DL therapy of PWS and to compare the safety and efficacy of ICG+DL with the standard treatment, flashlamp-pumped pulsed dye laser (FPDL).In a prospective randomized controlled clinical study, 31 patients with PWS were treated with FPDL (λ(em)=585 nm, 6 J cm(-2) , 0.45 ms pulse duration) and ICG+DL (λ(em)=810 nm, 20-50 J cm(-2) , 10-25 ms pulse duration, ICG-concentration: 2 mg kg(-1) body weight) in a split-face modus in one single treatment setting that included histological examination (haematoxylin and eosin, CD34). Two blinded investigators and the patients assessed clearance rate, cosmetic appearance and side-effects up to 3 months after treatment.ICG+DL therapy induced photocoagulation of medium and large blood vessels (>20 μm diameter) but not of small blood vessels. According to the investigators' assessment, clearance rates and cosmetic appearance were better after ICG+DL therapy than after FPDL treatment (P=0.114, P=0.291, respectively), although not up to a statistically significant level, whereas patients considered these parameters superior (P=0.003, P=0.006, respectively). On a 10-point scale indicating pain during treatment, patients rated ICG+DL to be more painful (5.81 ± 2.12) than FPDL treatment (1.61 ± 1.84).ICG+DL represents a new and promising treatment modality for PWS, but laser parameters and ICG concentration need to be further optimized.