PRIMARY HYPERPARATHYROIDISM: FIVE CASES IN ONE FAMILY
Authors: R N FROHNER, J C WOLGAMOT
Journal: Annals of Internal Medicine (1954)

Article1 April 1954PRIMARY HYPERPARATHYROIDISM: FIVE CASES IN ONE FAMILYRICHARD N. FROHNER, M.D., JOHN C. WOLGAMOT, M.D.RICHARD N. FROHNER, M.D., JOHN C. WOLGAMOT, M.D.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-40-4-765 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptIn 1925 the first parathyroid adenoma was removed for the treatment of hyperparathyroidism.1 Since then approximately 600 cases have been reported. The occurrence of the disease in the same family has been described only three times: once in two siblings,2 once in father and daughter,3 and once in cousins.4 This report describes five cases in siblings. Each patient had all the criteria of the primary disease; each patient was operated on and found to have one or more parathyroid adenomas.CASE REPORTSCase 1. A 25 year old married female was seen on August 5, 1947, complaining of pain in...Bibliography1. Mandl F: Hyperparathyroidism; a review of historical developments and the present state of knowledge on the subject, Surgery 21: 394, 1947. MedlineGoogle Scholar2. GoldmanSmyth LFS: Hyperparathyroidism in siblings, Ann. Surg. 104: 971, 1936. CrossrefMedlineGoogle Scholar3. ShallowFry TAKE: Parathyroid adenoma; occurrence in father and daughter, Surgery 24: 1020, 1948. MedlineGoogle Scholar4. SchneiderKygerMcCullagh RWEREP: Primary hyperparathyroidism; report of 10 cases, Cleveland Clin. Quart. 14: 246 (Oct.) 1947. CrossrefGoogle Scholar5. FitzHallman TEBL: Mental changes associated with hyperparathyroidism, Arch. Int. Med. 89: 547, 1952. CrossrefGoogle Scholar6. EllsworthHoward RJE: Studies on the physiology of the parathyroid glands. VII. Some responses of normal human kidneys and blood to intravenous parathyroid extract, Bull. Johns Hopkins Hosp. 55: 296 (Nov.) 1934. Google Scholar7. AlbrightReifenstein FEC: The parathyroid glands and metabolic bone disease; selected studies, 1948, The Williams and Wilkins Co., Baltimore, p. 75. Google Scholar8. HowardHopkinsConnor JETRTB: On certain physiologic responses to intravenous injection of calcium salts into normal, hyperparathyroid and hypoparathyroid persons, J. Clin. Endocrinol. and Metabolism 13: 1, 1953. CrossrefGoogle Scholar9. AlbrightReifenstein FEC: The parathyroid glands and metabolic bone disease; selected studies, 1948, The Williams and Wilkins Co., Baltimore, p. 46. Google Scholar10. UnderdahlWoolnerBlack LOLBBM: Multiple endocrine adenomas: report of 8 cases in which the parathyroids, pituitary and pancreatic islets were involved, J. Clin. Endocrinol. and Metabolism 13: 20, 1953. CrossrefGoogle Scholar11. SchneiderRobnett RWAH: Diagnosis of obscure hyperparathyroidism, Cleveland Clin. Quart. 18: 66, 1951. CrossrefGoogle Scholar12. Rogers HM: Parathyroidism adenoma and hypertrophy of the parathyroid glands, J. A. M. A. 130: 22, 1946. CrossrefMedlineGoogle Scholar13. RogersKeatingMorlockBarker HMFRCGNW: Primary hypertrophy and hyperplasia of the parathyroid glands associated with duodenal ulcer, Arch. Int. Med. 79: 307, 1947. CrossrefGoogle Scholar14. RobinsonBlackSpragueTillisch AWBMRGJH: Hyperparathyroidism due to diffuse primary hyperplasia and hypertrophy of the parathyroid glands: report of case, Proc. Staff Meet., Mayo Clin. 26: 441 (Nov. 21) 1951. MedlineGoogle Scholar15. Case records of the Massachusetts General Hospital: Case 37392, New England J. Med. 245: 504 (Sept. 27) 1951. CrossrefMedlineGoogle Scholar16. AlbrightKerr HLRC: Primary hyperplasia of parathyroid glands; report of a case with coincident duodenal ulcer, J. A. M. A. 148: 1218, 1952. CrossrefMedlineGoogle Scholar17. AlbrightReifenstein FEC: The parathyroid glands and metabolic bone disease; selected studies, 1948, The Williams and Wilkins Co., Baltimore, p. 96. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Great Falls, Montana*Received for publication August 10, 1953.From the Departments of Internal Medicine and Orthopedic Surgery, Great Falls Clinic, Great Falls, Montana.Presented in part at the Regional Meeting of the American College of Physicians, October, 1952, Great Falls, Montana. 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AURBACH, M.D.The relationship of hereditary hyperparathyroidism to endocrine adenomatosisHyperparathyroidismNeonatal Tetany Diagnostic Lead to Hyperparathyroidism in the MotherPETER HUTGHIN, M.D., DAVID M. KESSNER, M.D.Familial HyperparathyroidismThe ParathyroidsHyperparathyroidism in Relation to PregnancyHyperparathyroidism Analysis of Recent Experiences, Clinical Spectrum, and Diagnostic TestsFRANK A. RIDDICK JR., M.D., ERIC REISS, M.D.Peptic Ulcer in Primary Hyperparathyroidism An Analysis of Fifty-two CasesW. T. WILDER, M.D., BOY FRAME, M.D., F.A.C.P., W. S. HAUBRICH, M.D.RECURRENT HYPERPARATHYROIDISM*GUNTER LAUBINGER, M.D., J. MARTIN MILLER, M.D., RICHMOND W. SMITH JR., M.D.HEREDITARY HYPERPARATHYROIDISM ASSOCIATED WITH RECURRENT PANCREATITIS*†CHARLES E. JACKSON, M.D., F.A.C.P.KnochensystemParathyreoideaPathogenese des primären und sekundären Hyperparathyreoidismus und der renalen OsteomalaciePathogenese des primären und sekundären Hyperparathyreoidismus und der renalen Osteomalacie 1 April 1954Volume 40, Issue 4Page: 765-773KeywordsFallsHyperparathyroidismOrthopedic surgeryParathyroid tumors Issue Published: 1 April 1954 PDF downloadLoading ...