tbuckley/cabot-search huggingface dataset:
Seroprevalence to cytomegalovirus in the Portuguese population, 2002-2003
Authors: S Lopo, E Vinagre, P Palminha, M T Paixão, P Nogueira, M G Freitas
Journal: Eurosurveillance (2011)

The prevalence of cytomegalovirus (CMV) infections ranges between 50% and 85% in adults in the United States, and its epidemiology varies in different regions of the world and between socioeconomic and age groups. In Portugal, no study has been carried out to date to determine the prevalence of CMV in the general population. Under the second National Serological Survey conducted in continental Portugal in 2001–2002, we estimated the prevalence of individuals with antibodies to CMV using indirect immunofluorescence to detect virus-specific IgG. The population sample included 2,143 individuals of both sexes and different ages from all 18 districts in Portugal. The national seroprevalence of CMV was determined as 77%. We analysed the proportion of CMV IgG by sex, age group and district of residence. This was the first nationally representative study of seroprevalence of CMV in Portugal. The results of the study indicate that CMV infection is highly prevalent in the population and occurs mainly in the first years of life.
Are panic attacks traumatic stressors?
Authors: R J McNally, B M Lukach
Journal: American Journal of Psychiatry (1992)

Like typical stressors that produce posttraumatic stress disorder (PTSD), panic attacks are sudden, unpredictable, and often perceived as life-threatening. Structured interviews with 30 subjects with panic disorder revealed that five (17%) and two (7%) met lifetime and current DSM-III-R PTSD criteria, respectively, following their most terrifying panic attack. PTSD produced by panic is less severe than PTSD produced by either rape or combat.
The Relation of Chemical Influences, Including Diet and Endocrine Disturbances, to Epilepsy
Authors: H. Rawle Geyelin
Journal: Annals of Internal Medicine (1929)

Article1 January 1929The Relation of Chemical Influences, Including Diet and Endocrine Disturbances, to EpilepsyH. RAWLE GEYELIN, M.D.H. RAWLE GEYELIN, M.D.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-2-7-678 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptI had expected to speak in relation to epilepsy and endocrine disease, but the work along this line has not reached a stage where it is suitable to report it. I will, therefore, limit my remarks to three subjects: First, the effect of fasting and the ketogenic diet upon the course of epilepsy; sceond, the effect of the fasting and ketogenic diet upon the acid base equilibrium, and, third, I will tabulate the results of therapy as I have outlined it, with the old attempt to offer a tentative new classification of this condition.Work was begun by us on... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: New York City†Proof submitted to author but not returned, Editor.*Informal address as part of a Symposium on Epilepsy, at the Twelfth Annual Clinical Session of The American College of Physicians, New Orleans, La., March 7, 1928. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byKetogenic Diet in Cancer Prevention and Therapy: Molecular Targets and Therapeutic OpportunitiesClassic ketogenic diet (and its modifications) - the therapy for epileptiform conditions caused by some defects of carbohydrate and fat metabolism. Part I. Ketogenic diet mechanisms of actionHistory and Origin of the Ketogenic Diet 1 January 1929Volume 2, Issue 7Page: 678-681KeywordsDietEpilepsy ePublished: 1 December 2008 Issue Published: 1 January 1929 PDF downloadLoading ...
Baseline Assessment Of GPI-Anchored Protein Deficient Blood Cells In Patients With Bone Marrow Failure (The OPTIMA study)
Authors: Naoshi Obara, Shigeru Chiba, Kohei Hosokawa, Chiharu Sugimori, Masaki Yamamoto, Hideyoshi Noji, Yuji Yonemura, Yoshihiko Nakamura, Kiyoshi Ando, Tatsuya Kawaguchi, Tsutomu Shichishima, Haruhiko Ninomiya, Jun-ichi Nishimura, Yuzuru Kanakura, Shinji Nakao
Journal: Blood (2013)
Early restaging positron emmision tomography (PET) with 18F-fluorodeoxyglucose ((18)FDG) predicts outcome in patients with aggressive non Hodgkin's lymphoma (NHL).
Authors: Karoline Spaepen, S Stroobants, Patrick Dupont, P Vanderberghe, José Thomas, T de Groot, J Balzarini, C De Wolf-Peeters, Luc Mortelmans, Gregor Verhoef
Journal: Blood (2001)
Is a breach of human rights
Authors: D. Holdstock
Journal: BMJ (1996)

Table 1-Correlation coefficients between height and waist circumference in subjects identified by waist circum- ference action level 1 (94 cm in men and 80 cm in women) Men WomenWaist <94 cm Waist ¢94 cm Waist <80 cm Waist ¢80 cm Age (years) No
Pulmonary Phototherapy for Treating Carbon Monoxide Poisoning
Authors: Luca Zazzeron, Chen Liu, Walfre Franco, Akito Nakagawa, William A. Farinelli, Donald B. Bloch, R. Rox Anderson, Warren M. Zapol
Journal: American Journal of Respiratory and Critical Care Medicine (2015)

Carbon monoxide (CO) exposure is a leading cause of poison-related mortality. CO binds to Hb, forming carboxyhemoglobin (COHb), and produces tissue damage. Treatment of CO poisoning requires rapid removal of CO and restoration of oxygen delivery. Visible light is known to effectively dissociate CO from Hb, with a single photon dissociating one CO molecule.To determine whether illumination of the lungs of CO-poisoned mice causes dissociation of COHb from blood transiting the lungs, releasing CO into alveoli and thereby enhancing the rate of CO elimination.We developed a model of CO poisoning in anesthetized and mechanically ventilated mice to assess the effects of direct lung illumination (phototherapy) on the CO elimination rate. Light at wavelengths between 532 and 690 nm was tested. The effect of lung phototherapy administered during CO poisoning was also studied. To avoid a thoracotomy, we assessed the effect of lung phototherapy delivered to murine lungs via an optical fiber placed in the esophagus.In CO-poisoned mice, phototherapy of exposed lungs at 532, 570, 592, and 628 nm dissociated CO from Hb and doubled the CO elimination rate. Phototherapy administered during severe CO poisoning limited the blood COHb increase and improved the survival rate. Noninvasive transesophageal phototherapy delivered to murine lungs via an optical fiber increased the rate of CO elimination while avoiding a thoracotomy.Future development and scaling up of lung phototherapy for patients with CO exposure may provide a significant advance for treating and preventing CO poisoning.
Cooperative and redundant signaling of leukotriene B4 and leukotriene D4 in human monocytes
Authors: L.Y. Chen, M. Eberlein, S. Alsaaty, A. Martinez-Anton, J. Barb, P. J. Munson, R. L. Danner, Y. Liu, C. Logun, J. H. Shelhamer, G. Woszczek
Journal: Allergy (2011)

Leukotriene B(4) (LTB(4)) and cysteinyl leukotrienes (cysLTs) are important immune mediators, often found concomitantly at sites of inflammation. Although some of the leukotriene-mediated actions are distinctive (e.g., bronchial constriction for cysLTs), many activities such as leukocyte recruitment to tissues and amplification of inflammatory responses are shared by both classes of leukotrienes.We used human monocytes to characterize leukotriene-specific signaling, gene expression signatures, and functions and to identify interactions between LTB(4)- and cysLTs-induced pathways.Responsiveness to leukotrienes was assessed using oligonucleotide microarrays, real-time PCR, calcium mobilization, kinase activation, and chemotaxis assays.Human monocytes were found to express mRNA for high- and low-affinity LTB(4) receptors, BLT(1) and BLT(2), but signal predominantly through BLT(1) in response to LTB(4) stimulation as shown using selective agonists, inhibitors, and gene knock down experiments. LTB(4) acting through BLT(1) coupled to G-protein α inhibitory subunit activated calcium signaling, p44/42 mitogen-activated protein kinase, gene expression, and chemotaxis. Twenty-seven genes, including immediate early genes (IEG), transcription factors, cytokines, and membrane receptors were significantly up-regulated by LTB(4). LTB(4) and LTD(4) had similar effects on signaling, gene expression, and chemotaxis indicating redundant cell activation pathways but costimulation with both lipid mediators was additive for many monocyte functions.Leukotriene B(4) and LTD(4) display both redundant and cooperative effects on intracellular signaling, gene expression, and chemotaxis in human monocytes. These findings suggest that therapies targeting either leukotriene alone may be less effective than approaches directed at both.
Neurogranin Levels in Cerebrospinal Fluid
Authors: Henrik Zetterberg, Kaj Blennow
Journal: JAMA Neurology (2015)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Neurology HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Neurology journal
Casebook of Neuropsychiatryedited by Trevor A. Hurwitz, M.B.Ch.B., and Warren T. Lee, M.D., Ph.D. Washington, DC, American Psychiatric Publishing, 2013, 383 pp., $75.00 (paper).
Authors: Sheldon Benjamin, Barbara Schildkrout, Margo D. Lauterbach
Journal: American Journal of Psychiatry (2013)
Abstract 5471: Peroxisome Proliferator-Activated Receptor-{gamma} Activation Reduces Inflammation in Atherosclerosis as Assessed by Serial In Vivo Fluorescence Molecular Imaging
Authors: Kiyuk Chang, Jose-Luiz Figueiredo, Rainer Kohler, Sanjeev Francis, Purvish Patel, Jason McCarthy, Ralph Weissleder, Jorge Plutzky, Farouc Jaffer
Journal: Circulation (2008)

Background: Although indirect evidence suggests that peroxisome proliferator-activated receptor (PPAR)-γ agonists modulate atherosclerosis, their effects have not been directly imaged, tracked, or ...
Abstract 1988: Genomic Expression Pathways Associated to Brain Injury after Cardiopulmonary Bypass
Authors: Basel Ramlawi, Hasan Otu, Isaac S Kohane, Cesario Bianchi, Frank W Sellke
Journal: Circulation (2006)

Background: Neurologic injury after cardiac surgery, often manifested as neurocognitive decline (NCD), is a common postoperative complication. We studied acute variations in gene expression profile...
Flow cytometric testing of susceptibilities of Mycobacterium avium to amikacin, ciprofloxacin, clarithromycin and rifabutin in 24 hours
Authors: R.M. Vena, E.L. Munson, D.J. DeCoster, C.L. Croke, D.B. Fett, S.M. Callister, R.F. Schell
Journal: Clinical Microbiology and Infection (2000)
Hereditary non-polyposis colorectal cancer associated with disseminated superficial porokeratosis. Microsatellite instability in skin tumours
Authors: M. Takata, F. Shirasaki, T. Nakatani, K. Takehara
Journal: British Journal of Dermatology (2000)

Journal Article Hereditary non‐polyposis colorectal cancer associated with disseminated superficial porokeratosis. Microsatellite instability in skin tumours Get access M. Takata, M. Takata Department of Dermatology, Kanazawa University School of Medicine, 13‐1 Takara‐machi, Kanazawa 920‐8641, Japan Minoru Takata. E‐mail: takata@med.kanazawa‐u.ac.jp Search for other works by this author on: Oxford Academic Google Scholar F. Shirasaki, F. Shirasaki Department of Dermatology, Kanazawa University School of Medicine, 13‐1 Takara‐machi, Kanazawa 920‐8641, Japan Search for other works by this author on: Oxford Academic Google Scholar T. Nakatani, T. Nakatani Department of Dermatology, Kanazawa University School of Medicine, 13‐1 Takara‐machi, Kanazawa 920‐8641, Japan Search for other works by this author on: Oxford Academic Google Scholar K. Takehara K. Takehara Department of Dermatology, Kanazawa University School of Medicine, 13‐1 Takara‐machi, Kanazawa 920‐8641, Japan Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 143, Issue 4, 1 October 2000, Pages 851–855, https://doi.org/10.1046/j.1365-2133.2000.03789.x Published: 01 October 2000
Abstract 10021: Oral Lycopene Supplementation Improves Endothelial Function in Patients with Cardiovascular Disease: A Randomised Controlled Trial
Authors: Parag R Gajendragadkar, Annette Hubsch, Kaisa Maki-Petaja, Martin Serg, Ian B Wilkinson, Joseph Cheriyan
Journal: Circulation (2012)

Introduction A ‘Mediterranean diet’ rich in antioxidants may reduce the incidence of cardiovascular disease (CVD). Lycopene is a potent antioxidant and carotenoid component in tomatoes. Association...
Carbamates in the Chemotherapy of Leukemia. III. The Relationship between Chemical Structure and Anti-Leukemic Action of a Series of Urethan Derivatives
Authors: Howard E. Skipper, Carl E. Bryan
Journal: JNCI Journal of the National Cancer Institute (1949)

Carbamates in the Chemotherapy of Leukemia. III. The Relationship between Chemical Structure and Anti-Leukemic Action of a Series of Urethan Derivatives Howard E. Skipper, Howard E. Skipper Search for other works by this author on: Oxford Academic PubMed Google Scholar Carl E. Bryan Carl E. Bryan Biochemistry Division, Southern Research Institute, Birmingham, Ala. Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 9, Issue 5-6, April-June, Pages 391–397, https://doi.org/10.1093/jnci/9.5-6.391 Published: 01 April 1949 Article history Received: 27 September 1948 Published: 01 April 1949
Ketamine versus aminophylline for status asthmatic in children: A randomized, controlled trial
Authors: Abhimanyu Tiwari, Vishal Guglani, Kana Ram Jat
Journal: European Respiratory Journal (2014)

Background:  There is lack of consensus regarding use of second line adjuvant therapies in children with acute asthma who respond poorly to standard therapy.   Objectives:  To evaluate efficacy and safety of ketamine as compared to aminophylline in children with acute exacerbation of asthma.   Methods:  This RCT enrolled children of 1 to 12 years of age with acute asthma having Pediatric Respiratory Assessment Measure (PRAM) score ≥ 5 at 2 hours of standard therapy. Patients were randomized to intravenous ketamine OR aminophylline. Primary outcome measure was change in PRAM score.   Results:  A total of 48 subjects, 24 in each group, were enrolled. Change in PRAM score at three hours of intervention was similar in both the groups with a change of 4.00±1.25 and 4.17±1.68 (mean difference 0.16; 95% CI -1.02, 0.69; p=0.699) in ketamine and aminophylline group respectively. At three hours of intervention PRAM score was similar between the groups (3.79±1.84 versus 3.88±1.92; mean difference 0.08; 95% CI -1.18, 1.01; p=0.879) and it decreased significantly from enrollment in both the groups (p=0.000 for both group) without any significant adverse effects. Secondary outcomes (changes in pO2, pCO2 and PEFR, duration of hospital stay, need for mechanical ventilation) were similar between groups.   Conclusion:  Ketamine and aminophylline were equally effective for improvement in PRAM score in children with acute asthma and any of these two drugs may be used for children with acute asthma who responds poorly to standard therapy, depending on availability of drug and experience of users with drug.  Trial is registered at Clinical Trials Registry-India: CTRI/2013/09/004000.
GMC to hold a meeting with its critics
Authors: Bryan Christie
Journal: BMJ (2001)

The General Medical Council has organised a special one day consultative conference next month, when it will discuss its modernisation plans with its critics in an attempt to forge an agreement.

The initiative has been welcomed by the BMA, which warned recently that it would be forced to withdraw support from the GMC's system of revalidation as currently proposed.

The BMA council's chairman, Dr Ian, Bogle has criticised the plans as not having been “fully thought through” (5 May, p 1084). The decision …
DNA Content Analysis by Flow Cytometry and Cytogenetic Analysis in Mycosis Fungoides and Sézary Syndrome
Authors: Paul A. Bunn, Jacqueline Whang-Peng, Desmond N. Carney, Mark L. Schlam, Turid Knutsen, Adi F. Gazdar
Journal: Journal of Clinical Investigation (1980)

Flow cytometric (FCM) analysis of DNA content was performed on 82 lymph node and peripheral blood specimens from 46 patients with mycosis fungoides and the Sézary syndrome. Overall, 32 of the 46 patients (70%) had aneuploidy detected by FCM. Aneuploidy was present in 63% of the patients at the time of diagnosis before systemic therapy. In these patients, aneuploidy was frequently detected in blood and lymph node specimens scored as negative by cytology and histology, suggesting that unsuspected extracutaneous dissemination is present in many patients at the time of diagnosis.
Human keratin 8 variants promote mouse acetaminophen hepatotoxicity coupled with c‐jun amino‐terminal kinase activation and protein adduct formation
Authors: Nurdan Guldiken, Qin Zhou, Ozlem Kucukoglu, Melanie Rehm, Kateryna Levada, Annika Gross, Raymond Kwan, Laura P. James, Christian Trautwein, M. Bishr Omary, Pavel Strnad
Journal: Hepatology (2015)

Keratins 8 and 18 (K8/K18) are the intermediate filaments proteins of simple-type digestive epithelia and provide important cytoprotective function. K8/K18 variants predispose humans to chronic liver disease progression and poor outcomes in acute acetaminophen (APAP)-related liver failure. Given that K8 G62C and R341H/R341C are common K8 variants in European and North American populations, we studied their biological significance using transgenic mice. Mice that overexpress the human K8 variants, R341H or R341C, were generated and used together with previously described mice that overexpress wild-type K8 or K8 G62C. Mice were injected with 600 mg/kg of APAP or underwent bile duct ligation (BDL). Livers were evaluated by microarray analysis, quantitative real-time polymerase chain reaction, immunoblotting, histological and immunological staining, and biochemical assays. Under basal conditions, the K8 G62C/R341H/R341C variant-expressing mice did not show an obvious liver phenotype or altered keratin filament distribution, whereas K8 G62C/R341C animals had aberrant disulphide cross-linked keratins. Animals carrying the K8 variants displayed limited gene expression changes, but had lower nicotinamide N-methyl transferase (NNMT) levels and were predisposed to APAP-induced hepatotoxicity. NNMT represents a novel K8/K18-associated protein that becomes up-regulated after K8/K18 transfection. The more pronounced liver damage was accompanied by increased and prolonged JNK activation; elevated APAP protein adducts; K8 hyperphosphorylation at S74/S432 with enhanced keratin solubility; and prominent pericentral keratin network disruption. No differences in APAP serum levels, glutathione, or adenosine triphosphate levels were noted. BDL resulted in similar liver injury and biliary fibrosis in all mouse genotypes.Expression of human K8 variants G62C, R341H, or R341C in mice predisposes to acute APAP hepatotoxicity, thereby providing direct evidence for the importance of these variants in human acute liver failure.
Abstract 68: The Combination of Adenosine and Lidocaine (Adenocaine) Improves Postresuscitation Cardiac Function Following Cardiac Arrest
Authors: Asger Granfeldt, WeiWei Shi, L. Susan Schmarkey, Rong Jiang, C. Collin Bone, Lise Wogensen, Geoffrey P. Dobson, Else Tonnensen, Jakob Vinten-Johansen
Journal: Circulation (2010)
Experiences with the new genetic variant of Chlamydia trachomatis in Örebro county, Sweden – proportion, characteristics and effective diagnostic solution in an emergent situation
Authors: M Unemo, P Olcén, I Agné-Stadling, A Feldt, M Jurstrand, B Herrmann, K Persson, P Nilsson, T Ripa, H Fredlund
Journal: Eurosurveillance (2007)

Binary file ES_Abstracts_Final_ECDC.txt matches
Sequential therapy with gemcitabine and carboplatin followed by paclitaxel in first line treatment of advanced urothelial cancer
Authors: F. S. Farhat, C. Boutros, J. G. Kattan, G. Chahine, F. Younes, M. Ghosn
Journal: Journal of Clinical Oncology (2008)

16051 Background: Gemcitabine and platinum compounds represent the new standard combination for bladder cancer. Sequential adjunction of Paclitaxel could enhance the efficacy of this combination. Methods: This phase II multicentric study was based on the doublet gemcitabine 800 mg/m2 and carboplatine AUC= 2 on days 1 and 8 every 21 days for 4 cycles, followed sequentially by Paclitaxel 60 mg/m2 for 12 consecutive weeks. Disease assessment was recorded after each sequence. Results: From September 2004 to September 2007, 27 pts were enrolled: 25 achieved their treatment and 2 are still under therapy. There were 22 men and 5 women. Mean age was 68 (extremes 44 to 79). Primary tumor was localized in the bladder and renal pelvis in 25 and 2 pts respectively. 16 pts had locally advanced disease and 11 metastatic. Metastatic sites were lymphnodes in 21, lung in 5, bone in 4, liver in 3, and adrenal gland in 1. Mean number of cycles of the first sequence was 3.5 (extremes 1 to 4). Toxicities were mainly hematologic, including grade III neutropenia and anemia in 3 pts. Objective response was noted in 11 pts (44%), including 1 CR and 10 PR. 3 pts achieved SD and 11 progressed. 14 patients received the second sequence. Mean paclitaxel injection was 7 (extremes 2 to 12). Toxicities were limited to diarrhea and neurotoxicity in 1 pt each. OR was documented in 8 pts (57%) (3 CR and 5 PR), including the improvement of PR into CR in 2 pts. Median response duration was 6+ months. After a median follow-up of 7 months, 21 pts died and 6 are alive, including 2 maintained CR and 1 PR. Conclusion: sequential approach of advanced urothelial cancer by Gemcitabine and Carboplatine followed by Paclitaxel showed a high therapeutic index and seemed a good alternative to the combined triplet. Author Disclosure Employment or Leadership Consultant or Advisory Role Stock Ownership Honoraria Research Expert Testimony Other Remuneration ISCC