THE SIGNIFICANCE OF THE HYPERTROPHY AND HYPERPLASIA OF THE PARATHYROID GLANDS IN RICKETS AND OSTEOMALACIA
Authors: Russell M. Wilder, George M. Higgins, Charles Sheard
Journal: Annals of Internal Medicine (1934)

Article1 March 1934THE SIGNIFICANCE OF THE HYPERTROPHY AND HYPERPLASIA OF THE PARATHYROID GLANDS IN RICKETS AND OSTEOMALACIARUSSELL M. WILDER, M.D., GEORGE M. HIGGINS, PH.D., CHARLES SHEARD, PH.D.RUSSELL M. WILDER, M.D.Search for more papers by this author, GEORGE M. HIGGINS, PH.D.Search for more papers by this author, CHARLES SHEARD, PH.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-7-9-1059 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe earliest suggestion of a correlation between the function of the parathyroid glands and rickets is to be found in a contribution of Erdheim2in 1906. Extirpation of the parathyroid glands of young rats led to decalcification of the dentin of the incisor teeth and to dental abnormalities resembling those found in spontaneous rickets of rats. In the normal rats, after parathyroidectomy, an increased amount of osteoid tissue developed, especially in the ribs; fractures occurred and the deposit of calcium in the calluses of the fractures was deficient. A cartilage typical of rickets was not seen, but this discrepancy was...Bibliography1. DEMOLECHRIST VA: Wirkung des D-Vitamins am nebenschilddrüsenextirpierten Hund, Arch. f. exper. Path. u. Pharmakol., 1929, cxlvi, 361-376. CrossrefGoogle Scholar2. ERDHEIM J: Tetania parathyreopriva, Mitt. a. d. Grenzgeb. d. Med. u. Chir., 1906, xvi, 632-744. Google Scholar3. ERDHEIM J: Über Epithelkörperbefunde bei Osteomalacia, Sitzungsb. d. Akad. d. Wissensch. Mathemat.-naturw. Kl., Abt. 3, 1907, cxvi, 311-370. Google Scholar4. ERDHEIM J: Über den Kalkgehalt des wachsenden Knochens und des Callus nach der Epithelkörperchenextirpation, Frankf. Ztschr. f. Path., 1911, vii, 175-230. Google Scholar5. ERDHEIM J: Rachitis und Epithelkörperchen, Wien, 1914, 321 pp. Google Scholar6. HAMILTONSCHWARTZ BC: Rickets and hyperparathyroidism, Proc. Am. Soc. Clin. Invest., Jr. Clin. Invest., 1932, xi, 817. Google Scholar7. HESSLEWIS AFJM: Clinical experience with irradiated ergosterol, Jr. Am. Med. Assoc., 1928, xci, 783-788. CrossrefGoogle Scholar8. HESSWEINSTOCKRIVKIN AFMH: Effect of thyroparathyroidectomy on the action of irradiated ergosterol, Proc. Soc. Exper. Biol. and Med., 1929, xxvi, 555-556. CrossrefGoogle Scholar9. HESSWEINSTOCKRIVKIN AFMH: A further report on the effect of thyroparathyroidectomy on the action of irradiated ergosterol, Proc. Soc. Exper. Biol. and Med., 1930, xxvii, 298-299. CrossrefGoogle Scholar10. HIGGINSSHEARD GMC: Effects of selective solar irradiation on the parathyroid glands of chicks, Am. Jr. Physiol., 1928, lxxxv, 299-310. CrossrefGoogle Scholar11. HIGGINSSHEARDWILDER GMCRM: The effect of ultra-violet irradiation on rachitic chickens, Anat. Rec. (In press.) Google Scholar12. JOHNSON JL: Experimental chronic hyperparathyroidism; effects of administration of irradiated ergosterol, Am. Jr. Med. Sci., 1932, clxxxiii, 776-784. CrossrefGoogle Scholar13. KLEMPERER P: Parathyroid hyperplasia and bone destruction in generalized carcinomatosis, Surg., Gynec. and Obst., 1923, xxxvi, 11-15. Google Scholar14. KOZELKA FL: Reproduction and lactation in the absence of the parathyroid glands and their probable function, Proc. Jr. Biol. Chem., 1933, c, page lx. Google Scholar15. KOZELKAHARTBOHSTEDT FLEBG: Growth, reproduction, and lactation in absence of parathyroid glands, Jr. Biol. Chem., 1933, c, 715-729. CrossrefGoogle Scholar16. NONIDEZGOODALE JFHD: Histological studies on endocrines of chickens deprived of ultra-violet light; parathyroids, Am. Jr. Anat., 1927, xxxviii, 319-347. CrossrefGoogle Scholar17. SEEDSREED LCI: Administration of viosterol in human parathyroid tetany, Proc. Soc. Exper. Biol. and Med., 1931, xxviii, 379-380. CrossrefGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Rochester, Minnesota*Read before the Central Society for Clinical Research, Chicago, Illinois, October 27, 1933.From the Division of Medicine, Division of Experimental Medicine, and the Division of Physics and Biophysical Research, The Mayo Clinic and The Mayo Foundation. Nextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byA case of osteitis fibrosa cysticaKidney Function in Calcium and Phosphate MetabolismEndokrinologie in der KinderheilkundeThe cytology of the parathyroid gland of rats injected with parathyroid extract 1 March 1934Volume 7, Issue 9Page: 1059-1069KeywordsCalciumCartilageParathyroidParathyroidectomyRibs Issue Published: 1 March 1934 PDF downloadLoading ...