tbuckley/cabot-search huggingface dataset:
A CASE OF SPINDLE CELL SARCOMA OF THE BRONCHUS; SUPPLEMENTARY REPORT
Authors: Otto S. Baum, Gertrude Silverman, Rieva Rosh, Richard L. Riley
Journal: Annals of Internal Medicine (1942)

Case Reports1 October 1942A CASE OF SPINDLE CELL SARCOMA OF THE BRONCHUS; SUPPLEMENTARY REPORTOTTO S. BAUM, M.D., GERTRUDE SILVERMAN, M.D., RIEVA ROSH, M.D., RICHARD L. RILEY, M.D.OTTO S. BAUM, M.D.Search for more papers by this author, GERTRUDE SILVERMAN, M.D.Search for more papers by this author, RIEVA ROSH, M.D.Search for more papers by this author, RICHARD L. RILEY, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-17-4-750 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptIn November 1938 one of us (O. S. B.) reported a case of atelectasis of the right lower and middle lobes due to spindle cell sarcoma of the right main bronchus.1 The patient has since died, and this brief supplementary report, with a summary of the autopsy findings, is given for the sake of completeness, as well as because of the nature of the terminal illness. A brief summary of the early course of the disease is also given.The patient, R. Z., was a 32 year old housewife, first admitted to the Second (Cornell) Medical Division of Bellevue Hospital...Reference1. BAUMRICHARDSRYAN OSJHM: A case of atelectasis of the right lower and middle lobes with bronchoscopy demonstrating spindle cell sarcoma of the right main bronchus, ANN. INT. MED., 1938, xii, 699. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: New York, N. Y.*Received for publication March 31, 1941.From the Tuberculosis Service, the Department of Pathology, and the Department of Radiation Therapy of Bellevue Hospital, New York City. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byIntrapulmonary stromal mesotheliomaRESECTION OF PRIMARY PULMONARY SARCOMABronchogenic LeiomyosarcomaBRONCHOPULMONARY SARCOMAFIBROSARCOMA OF THE BRONCHUSFIBROSARCOMA OF THE BRONCHUS 1 October 1942Volume 17, Issue 4Page: 750-754KeywordsAutopsyBurnsGratitudePatient advocacyRadiation therapySarcoma ePublished: 1 December 2008 Issue Published: 1 October 1942 PDF downloadLoading ...
A CASE OF MARKED TORTUOSITY OF THE ABDOMINAL AORTA WITHOUT CALCIFICATION, CAUSING MILD ATTACKS OF SUBACUTE INTESTINAL OBSTRUCTION
Authors: Robert S. Palmer
Journal: Annals of Internal Medicine (1942)

Case Reports1 August 1942A CASE OF MARKED TORTUOSITY OF THE ABDOMINAL AORTA WITHOUT CALCIFICATION, CAUSING MILD ATTACKS OF SUBACUTE INTESTINAL OBSTRUCTIONROBERT S. PALMER, M.D., F.A.C.P.ROBERT S. PALMER, M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-17-2-358 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe consensus of present medical opinion is that atherosclerosis of the aorta is most marked in the abdominal portion and that it rarely if ever gives rise to clinical symptoms. This opinion is unanimously expressed in the recent textbooks consulted.1One encounters patients with marked general atherosclerosis of the large vessels complaining of various irregular digestive symptoms, various aches and pains, paresthesias, loss of weight and often mental retardation. Such patients seem to exemplify the results of advanced general senile changes rather than specific localizations, accompanied by rather than due to the atherosclerosis. Some authors2have held that digestive disorders...Bibliography1a. BOYD W: Textbook of pathology, 1938, Lea and Febiger, Philadelphia, p. 437. b. MUSSER, JOHN H.: Internal medicine, 1938, Lea and Febiger, Philadelphia, p. 541 (Diseases of blood vessels, E. V. ALLEN). c. WHITE, PAUL D.: Heart disease, 1931, Macmillan Co., New York, p. 526. d. COWDRY, EDMUND V.: Arteriosclerosis, 1933, Macmillan Co., New York, p. 253. Google Scholar2. HELD JW: Digestive symptoms caused by disease of the abdominal vessels with special reference to arteriosclerosis, Med. Jr. and Record, 1925, cxxii, 6-10; and 71-75. Google Scholar3. RIDLONBERKHEISER JEJ: Calcareous degeneration of the dorsal and lumbar aortae as a cause of backache, Jr. Am. Med. Assoc., 1923, lxxx, 1831. CrossrefGoogle Scholar4. GOODMAN EH: Angina abdominis, Am. Jr. Med. Sci., 1918, clx, 524. CrossrefGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Boston, Massachusetts*Received for publication February 7, 1940. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byA clinical roentgenological review of the literature for 1942, pertaining to the digestive tract 1 August 1942Volume 17, Issue 2Page: 358-361KeywordsAortaAtherosclerosisIntellectual disabilityPainWeight loss ePublished: 1 December 2008 Issue Published: 1 August 1942 PDF downloadLoading ...
Abstract 11758: The Heart Team: Myth Vs. Reality
Authors: Charles M Geller, Steven R Bergmann, Robert F Tranbaugh
Journal: Circulation (2014)

INTRODUCTION: The management of patients with complex CAD has led to the development of a heart team strategy involving shared decision making by a multidisciplinary team. Both the 2010 ESC/EACTS Guidelines and the 2012 AHA/ACC Criteria consider a heart team evaluation to be a class 1 indication to determine the treatment of patients with LM and/or 3VD prior to PCI. This study assessed our single institution’s compliance with this strategy. METHODS: Since July, 2012 patients with LM and/or 3VD or multi-vessel restenosis following prior PCI were recommended to have a multidisciplinary heart team discussion prior to any treatment. From November 1, 2012 through April 30, 2014 the results and therapeutic outcomes of all diagnostic cardiac catheterizations were analyzed. The total number of patients meeting criteria for a heart team evaluation, those actually having such a discussion and the subsequent treatment pathways were assessed. RESULTS: During the 18 month study period, 5740 patients underwent diagnostic cardiac catheterization. Of these, 522 patients met criteria for a heart team evaluation. A total of 266 patients (51%) were discussed by the heart team prior to treatment. Of this group, 153 patients received CABG (58%), 101 patients received PCI (38%), and 12 patients received medical management (5%). A total of 256 patients (49%) were not submitted for evaluation by the heart team. Of this group, 3 patients received CABG (1%), 227 received PCI (89%) and 26 received medical management (10%). The total PCI:CABG ratio for all patients was 17:1 and the total PCI:CABG ratio for those 522 patients with LM and/or 3VD was 3:1. Of this group, for those undergoing a heart team evaluation, the PCI:CABG ratio was 0.7:1 and without an evaluation the PCI: CABG ratio was 76:1 (p&lt;0.001). CONCLUSIONS: Despite established guidelines and a clinician consensus regarding the management strategy for complex CAD, half of eligible patients were not prospectively assessed by the heart team. When an evaluation was performed, the PCI:CABG ratio shifted from 76:1 to 0.7:1. Only through a collaborative process can optimal patient care be achieved.
Abstract 13572: The Mammalian Target of Rapamycin Activation is Required for Monocyte Proinflammatory Response in Patients with Coronary Artery Disease
Authors: Shanshan Gao, Weimin Liu, Xiaozhen Zhuo, Junhui Liu, Lijun Wang, Yue Wu, Zuyi Yuan
Journal: Circulation (2014)

Introduction and Hypothesis:  The regulation of nuclear factor kappa B (NF-kappaB) signaling and systematic proinflammatory response in atherosclerosis (AS) remain poorly defined. Therefore, we investigated the relationship between mammalian target of rapamycin (mTOR) and NF-kappaB signaling under proinflammatory state of circulating mononuclear cell (MNC) in coronary artery disease (CAD) patients.   Methods:  MNC was isolated from fasting blood samples of CAD patients (n = 31) and control subjects (n = 35). Serum interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α) were measured by enzyme-linked immunosorbent assay. NF-kappaB activity, p-mTOR and mTOR expression, and p65 nuclear translocation were analyzed by western blot in the isolated MNC. In vitro, Serum extracted from CAD patients (CAD serum) was used to treat MNC isolated from the control subjects. Pharmacological and genetic inhibitors of mTOR were also applied.   Results:  The serum IL-6 and TNF-α concentrations, NF-kappaB activity and p65 nuclear translocation in MNC were significantly elevated in the CAD group, and mTOR phosphorylation in MNC was also higher compared with control group. Serum extracted from CAD patients (CAD serum) induced a time-dependent phosphorylation of mTOR in parallel with aberrant NF-kappaB activation and the upregulation of inflammatory factors. Inhibition of mTOR with pharmacological or genetic means abolished CAD serum-triggered NF-kappaB activation and proinflammatory response. Moreover, lipid lowering drug statins partly, but not completely, blocked CAD serum-activated mTOR and proinflammatory responses.   Conclusion:  Our data demonstrate that the mTOR activation is required for the proinflammatory response via NF-kappaB-dependent pathway in MNC, which suggests underlying mechanism of atherosclerosis and more importantly, potential strategies to attenuate atherosclerosis in clinical practice.
Operative Approach to Congenital Aortic Stenosis in Childhood
Authors: W T MUSTARD, G A TRUSLER, J YAO
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Abstract 2501: Proteomics signature of lack of retinoic acid signal surveillance at early breast cancer stages
Authors: Stefano Rossetti, Wiam Bshara, Nicoletta Sacchi
Journal: Cancer Research (2014)

Abstract Endogenous retinoic acid (RA), the bioactive derivative of Vitamin A, is necessary for breast acinar morphogenesis. One of the hallmarks of early stage breast cancer, such as ductal carcinoma in situ (DCIS), is the inability to respond to RA morphogenetic action, which results in the uncontrolled growth of the mammary duct luminal cells. By imaging endogenous RA signaling during normal and aberrant breast acinar development in three dimensional (3D) culture, we found that the inability to form the acinar lumen can be traced to lack of activation of the RA receptor alpha (RARA) genomic function by endogenous RA variation. We further found that aberrant acinar morphogenesis, regardless of the causing factors, is marked by a distinct protein signature, which includes the upregulation of Annexin A8 (ANXA8). Forced expression of ANXA8 in breast epithelial cells was sufficient to disrupt 3D acinar architecture. Moreover, by screening DCIS tissue microarrays (TMAs), we found that ANXA8 expression correlates with tumor grade and stage. Thus, further development of this proteomics signature indicative of lack RA signal surveillance is expected to assist in the early detection of initial breast cancer stages. This work was funded by R01 CA127614, the Friends for an Earlier Breast Cancer Test Foundation, and the Terri Brodeur Breast Cancer Foundation. Citation Format: Stefano Rossetti, Wiam Bshara, Nicoletta Sacchi. Proteomics signature of lack of retinoic acid signal surveillance at early breast cancer stages. [abstract]. In: Proceedings of the 105th Annual Meeting of the American Association for Cancer Research; 2014 Apr 5-9; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2014;74(19 Suppl):Abstract nr 2501. doi:10.1158/1538-7445.AM2014-2501
Abstract 19954: Wider Dissemination of CPR Training with Chest Compression-only CPR and Changes in Bystander CPR in a Community
Authors: Taku Iwami, Tetsuhisa Kitamura, Chika Nishiyama, Tomonari Shimamoto, Takashi Kawamura, Seishiro Marukawa, Tetsuya Sakamoto
Journal: Circulation (2014)

Backgrounds: There have been few suggestions for communities how to train people in cardiopulmonary resuscitation (CPR) and to increase bystander CPR in a community. We developed a simplified 45-min training program of chest compression-only CPR (CCCPR) and have been promoting this short CPR training program in addition to conventional CPR training program. Objective: The objective of this study is to assess temporal trends in the proportion of bystander CPR and good quality CPR in the target area where we try to disseminate CPR more by use of simplified CPR training program with CCCPR. Method Design: A community-based intervention trial based on a population-based registry. Main outcome measure: Bystander CPR (chest compression-only and conventional) and good quality CPR among the bystander CPR. Participants: Citizens in Toyonaka City (population: approximately 380,000). Since Apr. 2010, we have trained for 14.9% of the population CPR (9.2% with CCCPR and 5.7% conventional CPR). Proportion of bystander C...
International Plan Focuses on Eradication of Polio and Containment of the Virus
Authors: C Marwick
Journal: JAMA (2000)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Delay in Treating Schizophrenia May Narrow Therapeutic Window of Opportunity
Authors: J Stephenson
Journal: JAMA (2000)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Rheumatoid Arthritis Trial
Authors: Tracy Hampton
Journal: JAMA (2004)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Campus Sexual Assault Perpetration
Authors: Jacquelyn Campbell
Journal: JAMA Pediatrics (2015)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Pediatrics HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Pediatrics journal
Recommendations for screening and early detection of common cancers in India
Authors: Preetha Rajaraman, Benjamin O Anderson, Partha Basu, Jerome L Belinson, Anil D' Cruz, Preet K Dhillon, Prakash Gupta, Tenkasi S Jawahar, Niranjan Joshi, Uma Kailash, Sharon Kapambwe, Vishwa Mohan Katoch, Suneeta Krishnan, Dharitri Panda, R Sankaranarayanan, Jerard M Selvam, Keerti V Shah, Surendra Shastri, Krithiga Shridhar, Maqsood Siddiqi, Sudha Sivaram, Tulika Seth, Anurag Srivastava, Edward Trimble, Ravi Mehrotra
Journal: The Lancet Oncology (2015)
801. Novel Targeting Non-AAV Parvoviral Vectors for Gene Therapy
Authors: Refael Itah, Igor Etingov, Clay Davis, Jacov Tal
Journal: Molecular Therapy (2004)

Top of pageAbstract
Parvoviruses infect and are able to kill mid- to late-embryo and cancer cells, but are not pathogenic to fully differentiated, nor to early embryonic cells. While their pathogenicity in vivo is highly species specific, they frequently cross the species barrier when infecting oncogenically transformed cells. Hence, the parvovirus minute virus of mice (MVM) can establish lytic infections in a variety of transformed human cells.

The tissue specificity of MVM is largely determined intracellularly by a capsid host-range determinant (hrd), which presumably interacts with an unknown cellular receptor-an interaction that facilitates uncoating of the infecting virus. When forced upon non-permissive cells, MVM was shown to evolve by generating variants with altered host-range properties. We have isolated and sequenced a number of such variants by end-point dilution and plaque purification. The isolates varied from the wild type virus by two types of mutations: a base substitution at nt 1955, in the single Sp1 binding site of the viral P38 promoter (which directs the synthesis of the two capsid proteins), and variable combinations of mutations in the codons for 6 amino acids within a 220 amino acid stretch of the viral capsid. Each of the viruses was examined for its ability to grow and induce cell death in a variety of cell lines. The results demonstrated that MVM isolates with different combinations of surface amino acids possessed characteristic host range properties.

The examination of MVM host range mutants in tissue culture cells represents only a fraction of what is likely to occur during normal infection. To overcome this limitation we have begun evaluating the host-range of MVM that bear capsid mutations by injecting mouse embryos in utero. The existence in the embryo of hundreds of different cell types in various differentiation states permits the examination, in parallel, of hundreds of different potential MVM/host-cell combinations. The in vivo analysis shows that the variant viruses exhibit striking differences in tissue specificity and pathogenicity compared to the parental strain. Understanding the recognition code between parvoviral capsid and the host cell components is expected to enable the targeting of this unique oncotropic activity to specific tumor cells.
Hematopoietic progenitor cells are innate Th2 cytokine‐producing cells
Authors: Z. Allakhverdi, G. Delespesse
Journal: Allergy (2011)

To cite this article : Allakhverdi Z, Delespesse G. Hematopoietic progenitor cells are innate Th2 cytokine‐producing cells. Allergy 2012; 67 : 4–9. Abstract Typically, hematopoietic stem/progenitor cells (HSPCs) reside within the bone marrow (BM) where they give rise to all hematopoietic populations. However, HSPCs also constantly egress from the BM into the blood and circulate through the peripheral tissues where upon encounter with inflammatory stimuli and epithelial cell‐derived cytokines they rapidly release very high levels of Th2 cytokines/chemokines and differentiate into Th2 effector cells. The novel concept of the dual function of HSPCs as hematopoietic precursors and potent Th2 cytokine producers has important clinical implications in various inflammatory conditions, including allergic diseases.
The Effect of Methylcholanthrene on the Genital Tracts of Rabbits and Dogs as Revealed by Biopsies and Exfoliative Cytology
Authors: E. S. Taylor, W. C. Pallas, W. T. Wikle, P. F. McCallin, S. N. Goodman
Journal: Cancer Research (1950)

Summary and Conclusions  An unsuccessful attempt was made to induce malignant tumors by methylcholanthrene in the cervices and vaginas of rabbits and dogs. The vaginas of rabbits were exposed to the carcinogen for as long as 76 weeks. The uterine cervices of the dogs were exposed to the same substance for as long as 190 weeks. Apparently, the genital tracts of these animals are very resistant to methylcholanthrene. Since no tumors were produced, it was impossible to study the histogenetic evolution of artificially produced tumors.