tbuckley/cabot-search huggingface dataset:
Calcitonin gene related peptide immunoreactivity in rat lung: light and electron microscopic study.
Authors: J M Lauweryns, L van Ranst
Journal: Thorax (1987)

Calcitonin gene related peptide immunoreactivity was investigated in the rat lung. Immunoreactive material was observed in nerve fibres surrounding bronchi, bronchioli, and blood vessels, and also in neuroendocrine cells and neuroepithelial bodies. In addition, the peptide was identified by immunoelectron microscopy in dense cored vesicles of granulated cells of the neuroepithelial bodies. These observations suggest that calcitonin gene related peptide plays a part in the regulatory function of the rat respiratory tract, exerting its influence by endocrine, paracrine, neurosecretory pathways, or a combination of these.
P894 PROPHYLAXIS OF DE NOVO HEPATITIS B VIRUS INFECTION WITH LAMIVUDINE IN HBsAg-NEGATIVE NAIVE RECIPIENTS OF HEPATITIS B CORE ANTIBODY-POSITIVE LIVERS: A 13-YEAR SINGLE-CENTER EXPERIENCE
Authors: M. Prieto, A. Braithwaite, M. García-Eliz, V. Aguilera, S. Benlloch, M. Berenguer, A. Rubín, C. Vinaixa, V. Hontangas
Journal: Journal of Hepatology (2014)
747 FAILURE OF LIVER STIFFNESS MEASUREMENT WITH FIBROSCAN: PREVALENCE AND DETERMINANTS
Authors: J.C. Marin-Gabriel, J.B. De-la-Cruz, M. Tocado, Y. Rodriguez-Gil, I. Fernandez-Vazquez, M.L. Manzano-Alonso, A.M. Martin-Algibez, J.C. Meneu-Diaz, F. Colina-Ruizdelgado, E. Moreno-Gonzalez, J.A. Solis-Herruzo, G. Castellano-Tortajada
Journal: Journal of Hepatology (2008)
Coronary angioplasty: a contemporary series analyzing procedural outcome, intermediate term outcome, and cumulative revascularization costs
Authors: R.I. Kacich, C.L. Lucore, G.J. Mishkel, R.V. Trask, K.J. Rocha-Singh, M.E. Shelton, H.W. Moses, F.L. Mikoll, R.W. Ligon
Journal: Journal of the American College of Cardiology (1998)
Doctors protest against surgeon held for six years at Guantanamo
Authors: L. Eaton
Journal: BMJ (2008)

More than 100 doctors have signed a petition to protest against the continued detention of an orthopaedic surgeon at Guantanamo Bay.

Ayman Saeed Batarfi, a 37 year old from Yemen, has been held for six years at the US prison base. His only crime, say the protestors, “was to treat civilian casualties in a war zone.”

The petition states that after his postgraduate studies in Pakistan and inspired by the Afghan trauma patients he had helped Dr Batarfi decided to work for a non-governmental organisation to renovate a hospital in Kabul in spring 2001.

“With the chaos …
Phylogenetic and Expression Analysis of the Glutamate-Receptor–Like Gene Family in Arabidopsis thaliana
Authors: Joanna C. Chiu, Eric D. Brenner, Rob DeSalle, Michael N. Nitabach, Todd C. Holmes, Gloria M. Coruzzi
Journal: Molecular Biology and Evolution (2002)

The ionotropic glutamate receptor (iGluR) gene family has been widely studied in animals and is determined to be important in excitatory neurotransmission and other neuronal processes. We have previously identified ionotropic glutamate receptor–like genes (GLRs) in Arabidopsis thaliana, an organism that lacks a nervous system. Upon the completion of the Arabidopsis genome sequencing project, a large family of GLR genes has been uncovered. A preliminary phylogenetic analysis divides the AtGLR gene family into three clades and is used as the basis for the recently established nomenclature for the AtGLR gene family. We performed a phylogenetic analysis with extensive annotations of the iGluR gene family, which includes all 20 ArabidopsisGLR genes, the entire iGluR family from rat (except NR3), and two prokaryotic iGluRs, SynechocystisGluR0 and Anabaena GluR. Our analysis supports the division of the AtGLR gene family into three clades and identifies potential functionally important amino acid residues that are conserved in both prokaryotic and eukaryotic iGluRs as well as those that are only conserved in AtGLRs. To begin to investigate whether the three AtGLR clades represent different functional classes, we performed the first comprehensive mRNA expression analysis of the entire AtGLR gene family. On the basis of RT-PCR, all AtGLRs are expressed genes. The three AtGLR clades do not show distinct clade-specific organ expression patterns. All 20 AtGLR genes are expressed in the root. Among them, five of the nine clade-II genes are root-specific in 8-week-old Arabidopsis plants.
Amount of pollen has an effect on the systemic and local levels of soluble ICAM-1 in patients with seasonal allergic rhinitis
Authors: M. Kato, T. Hattori, R. Ikeda, J. Yamamoto, T. Yamashita, N. Yanagita, I. Nakashima
Journal: Allergy (1996)

We investigated whether the amount of antigen has an effect on the systemic and local levels of soluble ICAM-1 (sICAM-1) in patients with pollinosis, and assessed its biologic significance. The levels of subjective symptoms and sICAM-1 in sera and nasal epithelial lining fluids (ELF) from 14 subjects with pollinosis (allergic group) and eight healthy subjects (control group) were measured from pre- to postseason in 1993 (total pollen count: 10,854/cm2) and 1994 (total pollen count: 415/cm2), and the results were compared with each other among the four groups. The levels of subjective symptoms and sICAM-1 in ELF from the allergic group significantly increased during the season in both 1993 and 1994. However, there was a significant difference (P < 0.01) between the levels of those in 1993 and those in 1994 during the season. The levels of sICAM-1 in sera from the allergic group were significantly upregulated during the seasons and postseasons only in 1993, and there was a significant difference (P < 0.05) between the levels in 1993 and those in 1994 during the postseason. We conclude that amount of pollen has an influence on the local and systemic levels of sICAM-1, as well as the scores of subjective symptoms, in patients with seasonal allergic rhinitis.
Intraocular Haemorrhage After Epidural Injection
Authors: C. J. Clark, J. Whitwell
Journal: BMJ (1961)

EARLY OCCLUSION IN STRABISMUSAll except one patient achieved bilateral central fixa- tion, the majority of the squints becoming alternating in type, with equal visual acuity.In over half the patients a temporary stage occurred in which the non-central fixation and the squint were transferred to the originally fixing eye.The excellence of these results is ascribed to the fact that none had had any previous treatment, the majority attending for treatment at a relatively early stage after the onset of the squint, and, perhaps even more important, to the intensive and rigorous nature of the occlusion used.I thank the surgeons of the Manchester Royal Eye Hospital for their reference of cases for study and treatment.
Effectiveness of lipid lowering drugs in general practice: Article illustrates major problem
Authors: T. W M Wang
Journal: BMJ (2003)

Iran has one of the greatest death rates from road traffic injuries (RTIs). There is no national injury surveillance in Iran and there is uncertainty on measures of RTIs. We studied the annual incidence of RTIs, the incidence of RTIs per 1000 vehicles and utilisation of vehicles in Tehran. <h3>Methods</h3> In this population-based study, 2488 households were randomly selected for interview using the registry of residential addresses. They were asked to report any RTIs in their household during the past year. <h3>Results</h3> 9100 inhabitants were included. There were 119 RTI (38.7% pedestrians, 46.2% motorcycler and 15.1% car occupants) and three deaths in the survey sample. The annual incidence of all RTIs for 100 000 population was 1310 (1080–1560) and that of fatal traffic injuries was 32.97 (6.8–96.3). Motorcycles were involved in 41.3% of RTIs that occurred for pedestrians. 19.7% of the households had motorcycle; 2.4% belonged to women. Women were mostly rode as passengers rather than driving a motorcycle. The annual incidence of collision RTI for 1000 motorcycle was 95. Moreover, 32.5% of the motorcycle riders had experienced non-collision transport accident (ie, fall). 58.5% of the households owned a car; 12.3% belonged to women. The annual incidence of car occupant RTI per 1000 car was 10. <h3>Conclusion</h3> Although the number of motorcycles is one third of cars, they are involved in a considerable proportion of RTIs; there is need for effective safety regulations to control this pattern.
Treatment With an Oral Proteinase Inhibitor Slows Gastric Emptying and Acutely Reduces Glucose and Insulin Levels After a Liquid Meal in Type II Diabetic Patients
Authors: Joyce G Schwartz, Difu Guan, Gary M Green, William T Phillips
Journal: Diabetes Care (1994)

OBJECTIVE To determine whether an oral trypsin/chymotrypsin inhibitor, POT II, will delay the rate of gastric emptying in recently diagnosed type II diabetic patients and improve their postprandial metabolic parameters. RESEARCH DESIGN AND METHODS Two gastric emptying studies were performedon each of six type II diabetic patients. During one study, the patient ingested a glucose/protein solution, and during the other study, the patientingested the same glucose/protein solution with the addition of 1.5 g ofPOT II, a putative stimulant of cholecystokinin (CCK) release. Each patient served as their own control subject. Each of the two oral solutions were administered to the patients in a counterbalanced order separated by at least 1 week. RESULTS Serum insulin, plasma glucose, plasma gastric inhibitory polypeptide (GIP) values, and the rate of gastric emptying were all significantly (P &amp;lt;0.05) decreased over the 2-h testing period when POT II was added tothe oral glucose/protein meal. The area under the curve above baseline for glucose with POT II was 75% of the glucose value without POT II. The areaunder the curve above baseline for insulin with POT II was 68% of the value without POT II. Plasma CCK was significantly increased by POT II 15 min postprandially. CONCLUSIONS A trypsin/chymotrypsin inhibitor, POT II, can delay therate of gastric emptying, and decrease postprandial plasma glucose levels, GIP levels, and serum insulin levels in type II diabetic patients diagnosed recently. Delay of gastric emptying in diabetic patients may provide a uniqueor adjunctive approach to the treatment of type II diabetes.
480. Gene Transfer to Gut K Cells for Physiologic Insulin Replacement in Diabetes
Authors: Eric C. Hsu, Scott Pownall, Timothy J. Kieffer, Yvonne Luu, Simon Leong, Paul D. Robbins, Xiao Xiao, Anthony T. Cheung
Journal: Molecular Therapy (2006)

We have previously demonstrated the feasibility of using gut K- cells as surrogate cells for insulin production. Transgenic mice expressing human insulin specifically in K-cells remained normoglycemic and glucose tolerant following destruction of their pancreatic |[beta]|-cells. However, a vector system is needed to transfer effective amount of the therapeutic insulin gene to duodenal epithelial cells in vivo. Previous efforts using viral and non-viral gene delivery vector resulted in some success. However, persistent transgene expression and detectable circulating proteins were not observed. Accordingly, this study is to identify a suitable viral vector and an optimal delivery methodology to achieve long-term gene transfer to the duodenum.
THE PROPHYLACTIC TREATMENT OF PATIENTS WHO HAVE HAD ALBUMINURIA IN A PREVIOUS PREGNANCY
Authors: L. C. Rivett
Journal: BMJ (1929)

ALBUIIINURIA OF PREGNANCY.the persistelit paini in thll\ epigastrium anid in the back, to thle right or left of the lohnver dorsal spine accor-ding as tlle iulcer is duodenial or gastric.The paiim, thouigh coinstant, is made worse by niourishment, and mayv necessitate the tse of opium, especially at niglht.Fr equently there a:,e iepeated lhaemorrrhages.The gauit, haggard, and ainaemic facies of tlie patient is a characteristic feature.In nmy experience manly of these patients responid very pooily or Inot at all to the carieful medical treatmenit of mlly medical colleagues, but a w-ell-lplannie(l operation gives immnnediate .andcopl)Iete relief wliichl, witlh reasoniable after-care, is,
P3-16-17: The Identification of Novel Microtubule Stabilizing Taccalonolides.
Authors: AL Risinger, J Li, J Peng, Z Chen, SL Mooberry
Journal: Cancer Research (2011)

Abstract Microtubule stabilizing agents, including the taxanes and epothilones, are some of the most important drugs used in the treatment of cancer. All of the microtubule stabilizers used clinically bind within the taxane site on microtubules and work through a similar mechanism of action. We have identified a new class of microtubule stabilizers, the taccalonolides, from plants of the genus Tacca. The most abundant taccalonolides, A and E, are classified as microtubule stabilizers due to their ability to disrupt both interphase and mitotic cellular microtubules, leading to mitotic arrest and apoptosis. However, they are unique from all other microtubule stabilizers in that they do not bind directly to microtubules or stimulate the polymerization of tubulin in biochemical preparations. The taccalonolide structure is characterized by a highly acetylated pentacyclic steroidal skeleton, which is also structurally distinct from all other microtubule targeted agents. The unique structure and mechanism of action of the taccalonolides, together with their ability to circumvent clinically relevant forms of taxane resistance, prompted our efforts to explore the structure-activity relationship of this class of molecules. We have isolated several novel taccalonolides, designated Z, AA, AB, AC, AF and AG, as well as multiple known taccalonolides. Each of these taccalonolides exhibited cellular microtubule stabilizing activity and antiproliferative actions against breast cancer cells. However, profound differences in potencies were noted with IC50 values ranging from 32 nM to 13 μM. These studies demonstrate that microtubule stabilizing activity is a shared trait among this class of molecules and that significant structure-activity relationships exist. Additionally, in vivo antitumor evaluations of taccalonolides A, E and N demonstrate that each of these molecules has activity in vivo and that taccalonolide A is the most effective against a syngeneic mammary model of breast cancer. Citation Information: Cancer Res 2011;71(24 Suppl):Abstract nr P3-16-17.
Bone Mineral Density Response to Estrogen Replacement in Frail Elderly Women
Authors: Dennis T. Villareal, Ellen F. Binder, Daniel B. Williams, Kenneth B. Schechtman, Kevin E. Yarasheski, Wendy M. Kohrt
Journal: JAMA (2001)

INCIDENCE OF OS-teoporotic fractures is in women older than 75 years, who constitute a rapidly expanding segment of the US population.Bone mineral density (BMD), which is a strong risk factor for osteoporosis, continues to decline with age.Indeed, recent prospective studies indicate that bone loss not only continues from middle age into old age but may in fact accelerate in elderly persons. 1 Given the progressive increase in physical frailty that typically occurs in elderly women, an osteoporotic fracture, particularly of the hip, often contributes to the loss of functional independence.3][4][5][6][7][8] In fact, it has been suggested that the response of bone to estrogens is greatest in those women furthest from menopause. 2,3[9][10][11] Because socioeconomic factors are the chief determinants of estrogen use by elderly women, 12 the benefits of HRT in observational studies may have been related to other lifestyle factors.Although prospective studies have shown an increase in BMD in response to HRT, 2,6-8 they typically have included women younger than 75 years.The effects of HRT on the BMD of very old, frail women at high risk for osteoporotic fractures have not been reported.Therefore, we performed a ran-
Use of Inert Gases and Carbon Monoxide to Study the Possible Influence of Countercurrent Exchange on Passive Absorption from the Small Bowel
Authors: John H. Bond, David G. Levitt, Michael D. Levitt
Journal: Journal of Clinical Investigation (1974)

The purpose of the present study was to quantitate the influence of countercurrent exchange on passive absorption of highly diffusible substances from the small intestine of the rabbit. The absorption of carbon monoxide, which is tightly bound to hemoglobin and therefore cannot exchange, was compared to the absorption of four unbound gases (H(2), He, CH(4), and (133)Xe), which should exchange freely. The degree to which the observed absorption of the unbound gases falls below that predicted from CO absorption should provide a quantitative measure of countercurrent exchange.CO uptake at high luminal Pco is flow-limited and, assuming that villus and central hemoglobin concentrations are equal, the flow that equilibrates with CO (F(co)) was calculated to equal 7.24 ml/min/100 g. The observed absorption rate of the unbound gases was from two to four times greater than would have been predicted had their entire uptake been accounted for by equilibration with F(co). This is the opposite of what would occur if countercurrent exchange retarded absorption of the unbound gases. The unbound gases have both flow- and diffusion-limited components, and F(co) should account for only the fraction of absorption that is flow limited. A simple model of perfusion and diffusion made it possible to calculate the fraction of the total uptake of unbound gases that was flow limited. This fraction of the total observed absorption rate was still about 1.8 times greater than predicted by CO absorption. A possible explanation for this discrepancy is that plasma skimming reduces the hemoglobin of villus blood to about 60% of that of central blood. Thus, F(co) is actually about 1.7 times greater than initially calculated, and with this correction, there is close agreement between the predicted and observed rates of absorption of each of the unbound gases. We conclude that countercurrent exchange does not influence passive absorption under the conditions of this study.
Changes in bile acid composition in patients with primary biliary cirrhosis induced by ursodeoxycholic acid administration
Authors: Andrea Crosignani, Mauro Podda, Pier Maria Battezzati, Emanuela Bertolini, Massimo Zuin, David Watson, Kenneth D. R. Setchell
Journal: Hepatology (1991)

We describe a detailed study of the effects of ursodeoxycholic acid administration on bile acid composition of the serum and bile of patients with primary biliary cirrhosis. Gas chromatography-mass spectrometry was used to analyze bile acids from 10 patients with primary biliary cirrhosis before and during ursodeoxycholic acid administration (500 mg/day, corresponding to approximately 8 mg/kg body wt), after group separation of the unconjugated and conjugated fractions by lipophilic anion exchange chromatography. These studies were directed at assessing whether the beneficial role of ursodeoxycholic acid in primary biliary cirrhosis was the consequence of a shift in the hydrophobic/hydrophilic balance of the bile acid pool and whether the hypercholeresis might result from the cholehepatic circulation of unconjugated ursodeoxycholic acid in bile. In basal conditions, the unconjugated bile acids accounted for only 5.5% and 2.5%, respectively, of the total bile acids of serum and bile; cholic acid was the major component of the conjugated fraction of serum and bile (56.0% +/- 4.0%, mean +/- S.E.M.), and ursodeoxycholic acid was present in only trace amounts. The conjugated fraction contained many unusual bile acids (representing 16.5% +/- 1.3% of total) including C25 bile acids, iso-chenodeoxycholic acid and several oxo-bile acids. After ursodeoxycholic acid administration biochemical indices of liver function all improved, but the proportions of the unconjugated bile acids in serum and bile did not significantly change.(ABSTRACT TRUNCATED AT 250 WORDS)
The Approach of a New Millennium
Authors: Lester S. King
Journal: JAMA (1990)

After one brief decade, we enter into a new millennium, whose approach exerts a certain fascination. If nothing else, we face imminent changes in some ingrained habits—it will indeed seem strange to date a letter or a check with the year 2000 (while remembering, of course, that the new millennium will really start only in 2001). However, will a transition from one millennium to another presage more important changes? The recent past offers some interesting data that on a smaller scale have considerable relevance. For example, the last decade of the 19th century, from about 1890 to 1900, witnessed such a major cultural transformation that it received a special name—the "mauve decade." Quite commonly it was called<i>fin de siècle</i>, "the end of a century," as if that provided an explanation. If we go back another 100 years to the end of the 18th century, we again find intense disturbance.
Endoscopic findings of enteropathy-type T-cell lymphoma
Authors: S. Yanai, T. Matsumoto, S. Nakamura, K. Fujisawa, T. Ueki, M. Hirahashi, T. Yao, M. Iida
Journal: Endoscopy (2007)

Endoscopic appearance of enteropathy-type T-cell lymphoma (ETL) has rarely been described [1] [2] [3] [4]. We report detailed endoscopic findings in two Japanese cases of ETL.
Disposal of remains of fetuses of under 24 weeks' gestation
Authors: R G Forster
Journal: BMJ (2003)

EDITOR—I write as the medical referee to the Wakefield cremation authority about the disposal by cremation of the remains of fetuses of less than 24 weeks' gestation.

Although I understand the emotive reasons for hospital authorities wishing to find a more sensitive way of disposing of fetuses of less than 24 weeks' gestation, it is important to recognise that currently such disposals are outside the scope of …
The Management of Giant Retinal Tears Using Perfluoroperhydrophenanthrene
Authors: Peter J. Kertes, Hussein Wafapoor, Gholam A. Peyman, Nassim Calixto, Hilary Thompson, Gholam A. Peyman, George A. Williams, Jane C. Werner, R. Joseph Olk, Harry W. Flynn, Hamid Mani, Ralph Paylor, Peter Campochiaro, Thomas O. Bennett, Joel A. Schulman, Kevin J. Blinder, Robert Wendel, Rickey Medlock, Bert M. Glaser, James G. Randall, Ching J. Chen, Jay L. Federman, William Tasman, Nalin J. Mehta, Nicholas Z. Zakov, George E. Sanborn, Neil Brourman, Michael J. Elman
Journal: Ophthalmology (1997)
Topical viscous lidocaine solution versus lidocaine spray for pharyngeal anesthesia in unsedated esophagogastroduodenoscopy
Authors: S. Amornyotin, W. Srikureja, W. Chalayonnavin, S. Kongphlay, S. Chatchawankitkul
Journal: Endoscopy (2009)

See also: Commentaire de travail de S. Amornyotin et al., pp. 581Endoscopy 2009; 41(07): 737-737DOI: 10.1055/s-0032-1306737
Thrombolytic Therapy with Urokinase in Pulmonary Thromboembolism.
Authors: Edward Genton
Journal: Annals of Internal Medicine (1968)

s1 May 1968Thrombolytic Therapy with Urokinase in Pulmonary Thromboembolism.Edward Genton, M.D. (Associate), Phillip S. Wolf, M.D. (Associate)Edward Genton, M.D. (Associate)Search for more papers by this author, Phillip S. Wolf, M.D. (Associate)Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-68-5-1186_1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThrombolytic therapy with the plasminogen activator, urokinase (UK), was evaluated in 13 patients with angiographically confirmed bilateral massive pumonary thromboembolism. UK was administered intravenously for 8 to 12 hr at a rate of 1,500 to 2,000 CTA units/lb per hour. In group 1 (five patients) all symptoms occurred within 2 weeks before UK with fresh emboli within 72 hr. Average mean pulmonary artery pressure equaled 38 mm Hg. Each had marked symptomatic blood gas and angiographic improvement after UK, and mean pulmonary artery pressure fell to 24 mm Hg. Group 2 (four patients) had symptoms longer than 2 weeks, plus... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Denver, Colorado PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 May 1968Volume 68, Issue 5Page: 1186-1186KeywordsPulmonary arteriesPulmonary embolismThromboembolism Issue Published: 1 May 1968 PDF DownloadLoading ...