SICKLE CELL DISEASE: REPORT OF A CASE WITH CEREBRAL MANIFESTATIONS IN THE ABSENCE OF ANEMIA
Authors: R K THOMPSON, J A WAGNER, C M MacLEOD
Journal: Annals of Internal Medicine (1948)

Case Reports1 November 1948SICKLE CELL DISEASE: REPORT OF A CASE WITH CEREBRAL MANIFESTATIONS IN THE ABSENCE OF ANEMIARAYMOND K. THOMPSON, M.D., JOHN A. WAGNER, M.D., CHRISTIE M. MACLEOD, M.D.RAYMOND K. THOMPSON, M.D., JOHN A. WAGNER, M.D., CHRISTIE M. MACLEOD, M.D.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-29-5-921 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptSickle cell disease was originally described by Herrick1in 1910, as anemia with sickle-shaped erythrocytes. During a crisis of sickling these characteristic cells become wedged in capillaries, often producing thrombosis. In the past 20 years increasing attention has centered about the histopathology of sickle cell disease, particularly with reference to the vascular thromboses so frequently noted. This vascular occlusive phenomenon results in a protean symptomatology dependent upon the vessels occluded. 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Author, Article, and Disclosure InformationAffiliations: Middletown, Connecticut*Received for publication September 5, 1947.†Resident in Neurosurgery, University of Maryland Hospital, Baltimore, Maryland.‡Assistant Professor, Neurosurgery and Neuropathology, University of Maryland Medical School.§Department of Laboratories, Middlesex Hospital, Middletown, Connecticut. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byProspective Brain Imaging Evaluation of Children with Sickle Cell Trait: Initial ObservationsSuperior sagittal sinus thrombosis with infarction in sickle cell trait.Cerebral infarction in sickle cell traitSickle Cell Trait and Multiple Cerebral InfarctionsThe morbidity of sickle cell traitThe Electroencephalogram in Neurological Complications of Sickle Cell Anemia (SS-Hemoglobinopathy)Neurological Manifestations in Sickle-Cell Disease With a Review of the Literature and Emphasis on the Prevalence of HemiplegiaBARRY A. 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LOCKARD CONLEY, M.D.Sickle-cell disease 1 November 1948Volume 29, Issue 5Page: 921-928KeywordsAnemiaCapillariesCellsHistopathologyNeuropathologyNeurosurgerySickle cell diseaseThrombosis ePublished: 1 December 2008 Issue Published: 1 November 1948 PDF downloadLoading ...