tbuckley/cabot-search huggingface dataset:
Abstract P389: Effects of Dietary Patterns on Vitamin D and Other Markers of Bone-Mineral Metabolism: Results From the Dash Trial
Authors: Ahmed Hassoon, Lawrence Appel, Edgar Miller
Journal: Circulation (2015)

Background: The relationship of CVD with vitamin D levels and other markers of bone-mineral metabolism is of substantial interest. The Dietary Approaches to Stop Hypertension (DASH) diet effectively lowers blood pressure and is now recommended to promote CV health. The effects of the DASH diet on vitamin D and other markers of bone-mineral metabolism is unknown. Objective: To determine the effect of dietary patterns on blood levels of vitamin D, PTH, and ionized calcium, and urinary excretion of calcium and phosphate. Methods: Data on study outcomes were available in 334 participants from the original DASH trial. Baseline levels were obtained from blood and urine collected at the end of the run-in while on the control diet. Participants were then randomized to control diet (37% kcal total fat); fruits &amp; vegetable diet (also 37% kcal total fat); or the DASH diet (27% kcal total fat). Follow-up levels were obtained during the last week of the eight-week intervention period. Results: Mean (±SD) baseline blood levels of vitamin D, PTH , and ionized calcium were 15.1±3.7ng/ml, 46.1±18.5 ng/ml and 1.3±0.06 mmol/l, respectively. For urinary calcium and phosphate were 126.8±45.3mg/dl and 715.0±277.3 mg/dl, respectively. See table for within-diet changes. The DASH diet, net of control, reduced vitamin D by -1.29ng/ml (P= 0.005). In stratified analyses, the reduction in vitamin D appeared more prominent in blacks, but the p-value for interaction (race*diet) was non-significant (P=0.21). Otherwise, the DASH diet had no significant effect on the other markers, net of control. Compared to control, the fruit &amp; vegetable diet reduced urinary calcium and phosphorus excretion. Conclusion: The DASH diet modestly reduced vitamin D levels among all participants, with potentially larger effects in blacks. The reduction in vitamin D levels might have resulted from the lower fat content of the DASH diet. Overall, during the eight-weeks of intervention, no major harm or benefit of the DASH diet was documented on biomarkers related to bone-mineral metabolism.
449. Evaluation of New Generation of Prostate Specific Replication Competent Adenoviruses with E1A-AR Chimera
Authors: Ying Li, Chien-lun Chen, Aarup Kubal, Qinghua Xia, Ronald Rodriguez
Journal: Molecular Therapy (2004)

Adenoviral vector-based gene therapy has been evaluated as a potential therapeutic for prostate cancer. The prostate specific conditionally replication competent adenoviruses (CRADs) are designed to replicate and lyse the prostate epithelium under the control of the E1A gene expression by a prostate specific promoter. Recently we have determined that E1A inhibits the androgen receptor (AR) function, resulting in the attenuation of prostate specific CRAD vectors. We designed E1A-AR fusion chimeras in a new generation of prostate specific replication competent adenoviruses to overcome the inhibition of AR and restore efficient ARE-dependent E1A expression. A series of CRADs with chimeric E1A-AR were constructed and evaluated in prostate cancer cells and non-prostate cancer cells. Here, we describe the function of recombinant adenoviruses with E1A-AR chimeric expression in in vitro study.
Severe hemolytic anemia associated with Hb Volga [β27(B9)Ala→Asp]: GCC→GAC at codon 27 in a Turkish family
Authors: M. Sözen, Ç. Karaaslan, R. Öner, F. Gümrük, M.A. Özdemir, C. Altay, A. Gürgey, C. Öner
Journal: American Journal of Hematology (2004)

Abstract A boy presented at age 4 years with severe congenital hemolytic anemia characterized by highly elevated reticulocyte count (30–50%) and prominent basophilic stippling. Hb had been 4 g/dL at age 7 months. The patient was on a monthly transfusion regimen up to the age of 7 years, when he underwent splenectomy. After removal of the spleen, his Hb stabilized at 11 g/dL. No abnormal pattern was detected in hemoglobin electrophoresis at pH 9 and 6. In‐vitro globin synthesis revealed the presence of an abnormal β‐chain in front of the γ‐chain. The β A /β X ratio was 0.77 at 30 min and 0.74 at 2 hr of incubation. Molecular analysis revealed that the patient had G C C→G A C alteration at codon 27 (β27(B9)Ala→Asp) causing the abnormal hemoglobin Volga. The β‐cDNA derived from the β‐Hb Volga allele could be differentiated from HbA β‐cDNA on silver‐stained gel. No imbalance in the mRNA of β A /β Hb Volga ratio was observed. Am. J. Hematol. 76:378–382, 2004. © 2004 Wiley‐Liss, Inc.
ABO BLOOD GROUPS IN THE ACCELERATED FORM OF HYPERTENSION
Authors: G A PERERA, G ADLER
Journal: Annals of Internal Medicine (1960)

Article1 July 1960ABO BLOOD GROUPS IN THE ACCELERATED FORM OF HYPERTENSIONGEORGE A. PERERA, M.D., F.A.C.P., GERALD ADLER, M.D.GEORGE A. PERERA, M.D., F.A.C.P.Search for more papers by this author, GERALD ADLER, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-53-1-84 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe accelerated ("malignant") form of hypertension is characterized by the presence of widespread necrotizing arteriolitis and proliferative endarteritis. When it appears after the prior development of primary (essential) hypertension, it has been regarded by some investigators as a phase representing an increased intensity of the hypertensive process.A number of clinical observations1, 2 support the view that factors other than tempo play at least a part. The present study deals with the frequencies of ABO blood groups.CLINICAL MATERIALThe ABO blood groups were determined in white and Negro men and women with the accelerated form of hypertension, there being...Bibliography1. PereraDamon GAA: Height, weight and their ratio in the accelerated form of primary hypertension, Arch. Int. Med. 100: 263, 1957. CrossrefGoogle Scholar2. Perera GA: The accelerated form of hypertension—a unique entity?, Tr. A. Am. Physicians 71: 62, 1958. MedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: New York, N. Y.*Received for publication December 8, 1959.From the Department of Medicine, Columbia University College of Physicians and Surgeons, and the Presbyterian Hospital, New York.†Aided by grants from the Union County, N. J., Heart Association, and the Albert H. and Jessie D. Wiggin Foundation.Requests for reprints should be addressed to George A. Perera, M.D., Department of Medicine, Columbia University College of Physicians and Surgeons, 620 West 168th Street, New York 32, N. Y. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byGenetic Variance and Heritability of Cardiovascular Risk Factors in Chinese Adolescent TwinsGenetics in Human HypertensionAbo and Rh blood groups in patients with coronary heart diseaseDie Korrelation von Blutgruppenantigenen und-substanzen mit hypertonischer ErkrankungA statistical appraisal on the relationship between non-ABO blood group systems and diseasesMedical genetics 1960 1 July 1960Volume 53, Issue 1Page: 84-86KeywordsBlood banksBlood groupsHeartHospital medicineHypertensionSurgeons ePublished: 1 December 2008 Issue Published: 1 July 1960 PDF downloadLoading ...
Use of Coronary Calcification Scores to Predict Coronary Heart Disease
Authors: Anthony S. Wierzbicki, Patrick J. Twomey, Timothy M. Reynolds, Mark J. Pletcher, Jeffrey A. Tice, Michael Pignone, Matthew J. Budoff, James Ehrlich, Harvey S. Hecht, John A. Rumberger, Robert C. Detrano, Philip Greenland, Terence M. Doherty, Stanley P. Azen, Laurie LaBree
Journal: JAMA (2004)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Abstract 16153: Exercise Stress Testing Triggers Immediate Changes in Cardiac Troponin I Levels in Patients With Advanced Heart Failure
Authors: Petr Jarolim, Michael J Conrad, David A Morrow, Josef Kautzner, Vojtech Melenovsky
Journal: Circulation (2011)

Background: Recent studies have shown that cardiac troponin (cTn) has prognostic implications throughout its range in patients with and without CAD. Elevations of cTn occur in heart failure and cor...
Abstract 13829: Endothelial Insulin Sensitisation Enhances Vascular Repair in Systemic Insulin Resistance and Improves Endothelial Function by Restoring Nitric Oxide Bioavailability
Authors: Anshuman Sengupta, Hema Viswambharan, Nadira Yuldasheva, Ben Mercer, Stacey Galloway, Noman Ali, Andrew Walker, Amir Aziz, Matthew Gage, Anna Skromna, Stephen Wheatcroft, Mark Kearney, Richard Cubbon
Journal: Circulation (2014)

Objectives: Insulin resistance is independently associated with vascular disease. Mice with heterozygous insulin receptor (IR) knock out (IRKO) are non-diabetic, yet exhibit hypertension, endothelial dysfunction and impaired vascular repair, with reduced endothelial progenitor cell (EPC) number/function. We hypothesise that intact endothelial insulin signalling is crucial for vascular function and that its selective restoration may rescue the vascular derangements seen in systemic insulin resistance.

Methods: We generated transgenic mice with Tie-2-driven human IR expression in endothelial cells (HIRECO). These, bred with IRKO, provide HIRECOxIRKO offspring, which were compared with IRKO. Glucocompetence was assessed using glucose- and insulin-tolerance tests and ELISA for plasma insulin concentration. Femoral artery injury was performed using angioplasty guide wires; vessels were excised at day 4 to quantify repair using Evans Blue dye. Circulating progenitor cells (CPC) were counted using FACS and cultured blood-derived EPCs counted using DiI/lectin stain. Finally, aortic rings were exposed to incremental acetylcholine and phenylephrine (PE) before and after incubation with the NOS inhibitor L-NMMA in organ baths to assess vasomotor function. Data are expressed as mean (SE) and compared using t-tests; *=p<0.05.

Results: HIRECOxIRKO and IRKO showed similar glucocompetence and insulin levels [0.8(0.1)ng/mL vs 0.7(0.2);p=0.8] but lower systolic BP [97(2)mmHg vs 106(3)*]. Vascular re-endothelialisation improved in HIRECOxIRKO [57(4)% vs 46(2)%*]. There was no recovery in peripheral CPC [99(10) vs 105(15);p=0.7], nor cultured EPC number [0.4(0.1)/HPF vs 0.4(0.2);p=0.99]. HIRECOxIRKO aortic rings displayed significantly less PE-induced constriction than IRKO [EC50 8.9(0.8)x107nM vs 6.3(0.9)x107nM*] and showed greater NO bioavailability [Post-L-NMMA PE EC50 4.1(0.8)x107nM vs IRKO 6.1(1.8)x107nM*].

Conclusion: HIRECOxIRKO show improved BP, endothelial function, NO bioavailability and vascular repair in the setting of global insulin resistance. This is not related to glucoregulation or EPC abundance. Endothelial insulin sensitisation may be a therapeutic target for vascular dysfunction in insulin resistance.
Abstract P032: Wine Consumption and Cognitive Function
Authors: Chelsey Kamson, Alexis K Bui, Beatrice A Golomb
Journal: Circulation (2015)

Background: Regular modest wine consumption may be linked favorably or adversely to cognition. Goal: To assess the cross-sectional relation between wine consumption frequency ( WineF ) &amp; cognitive indices. Method: Of 1018 adults age 20-85 without CVD or DM, 945 completed a food frequency questionnaire eliciting WineF. Frequency was of interest, since frequency of a food with antioxidant effects previously related favorably to cognitive indices in younger adults. Cognitive tests included grooved pegboard (time), Trails A &amp; B (time), digit symbol, Elithorn mazes, Stroop color word. Memory and attention tests included digit span and recurrent words; and digit vigilance. (Table legend shows coding). Regression (robust standard errors) assessed how WineF predicted cognitive performance. Since two prior dietary predictors showed age-dependency in relation to cognition (selectively evident in younger adults), assessment included age-stratified analysis. Covariates adjusted were known cognitive predictors (per this sample and/or the literature): age, sex, education, exercise, diet variables linked to cognition in this sample, and metabolic variables (glucose, LDL, systolic blood pressure), recognizing that adjustment for the latter could attenuate associations if these variables are mediating. Results: More frequent WineF predicted significantly better performance, in younger adults and often in the full sample, for the tests shown in the Table (fully adjusted model). These tests involved timed performance and/or constructs such as executive function. WineF did not relate significantly to the tests above of memory or attention (data not shown). Limitations: Alcohol bears risks and findings are observational. Heavy drinkers were poorly represented and findings need not apply to them. Conclusion: More frequent WineF in a study sample (with few heavy wine drinkers) was favorably linked to performance on cognitive tests related to timed performance and executive function, particularly in younger adults.
Abstract 662: Generation and characterization of antibodies specific for IL1RAP antigen to target quiescent and proliferating AML leukemic stem cells
Authors: Ping Jiang, Sharmili Roy, Jen Huang, Trang Dao-Pick, Jennifer Lu, Madhavi Mishra, Jeffrey Lin, Eric D. Hsi, Robert J. Tressler, Holger Karsunky
Journal: Cancer Research (2014)

Abstract We have isolated and characterized blast cells and leukemic stem cells (LSCs) enriched from AML patients and identified cell surface targets selectively expressed on AML blast cells and LSCs and not their normal hematopoietic stem cell counterparts. A series of potent, specific, monoclonal antibodies (mAbs) have been generated against one of these AML LSC targets, IL1RAP. IL1RAP mAb clones were characterized for patient binding properties and also evaluated in in vitro cell based assays and in in vivo tumor xenograft models. These monoclonal antibodies demonstrated promising binding profiles in primary AML patients’ samples and robust anti-tumor activity in in vitro cell based assays and in vivo tumor xenograft models. Specifically, select clones have a high degree of specific binding to AML primary patient samples (&amp;gt;90%), and specifically kill primary patient AML cells in complement-dependent cytotoxicity assays. These IL1RAP clones are being evaluated for inhibition of clonogenic potential of AML patient samples in vitro in colony forming assays and against normal clonogenic hematopoietic bone marrow derived stem cells. Select IL1RAP mAb clones evaluated in orthotopic AML tumor xenograft models have shown potent inhibition of tumor engraftment as well as significant tumor growth inhibition effects ranging from 80-90%. Because a key driver of LSC resistance is their quiescence, we also evaluated the antitumor effect of IL1RAP mAbs on quiescent AML cells in vitro. In summary, the patient binding profiles and in vitro and in vivo efficacy against AML cells indicates that targeting IL1RAP is a promising therapeutic approach for the treatment of AML and has the potential for effective eradication of AML LSCs and long term remission in the clinic. Citation Format: Ping Jiang, Sharmili Roy, Jen Huang, Trang Dao-Pick, Jennifer Lu, Madhavi Mishra, Jeffrey Lin, Eric D. Hsi, Robert J. Tressler, Holger Karsunky. Generation and characterization of antibodies specific for IL1RAP antigen to target quiescent and proliferating AML leukemic stem cells. [abstract]. In: Proceedings of the 105th Annual Meeting of the American Association for Cancer Research; 2014 Apr 5-9; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2014;74(19 Suppl):Abstract nr 662. doi:10.1158/1538-7445.AM2014-662
Dissociative symptoms in relation to childhood physical and sexual abuse
Authors: J A Chu, D L Dill
Journal: American Journal of Psychiatry (1990)

Studies have reported high rates of childhood abuse in people with psychiatric illness. This study examined whether dissociative symptoms are specific to patients with histories of abuse. Ninety-eight female psychiatric inpatients completed self-report instruments that focused on childhood history of trauma, dissociative symptoms, and psychiatric symptoms in general. Sixty-three percent of the subjects reported physical and/or sexual abuse. Eighty-three percent had dissociative symptom scores above the median score of normal adults, and 24% had scores at or above the median score of patients with posttraumatic stress disorder. Subjects with a history of childhood abuse reported higher levels of dissociative symptoms than those who did not.
Studies on dapsone induced haemolytic anaemia.
Authors: GIULIANO MANFREDI, GIUSEPPE PANFILIS, MAURIZIO ZAMPETTI, FULVIO ALLEGRA
Journal: British Journal of Dermatology (1979)

Journal Article Studies on dapsone induced haemolytic anaemia: I. METHAEMOGLOBIN PRODUCTION AND G‐6‐PD ACTIVITY IN CORRELATION WITH DAPSONE DOSAGE Get access GIULIANO MANFREDI, GIULIANO MANFREDI Istituto di Clinica Dermosifilopatica, Università degli Studi di Parma, Italy Dr Giuliano Manfredi, Istituto di Clinica Dermosifilopatica dell'Università di Parma, 1‐43100 PARMA, Italy Search for other works by this author on: Oxford Academic Google Scholar GIUSEPPE DE PANFILIS, GIUSEPPE DE PANFILIS Istituto di Clinica Dermosifilopatica, Università degli Studi di Parma, Italy Search for other works by this author on: Oxford Academic Google Scholar MAURIZIO ZAMPETTI, MAURIZIO ZAMPETTI Istituto di Clinica Dermosifilopatica, Università degli Studi di Parma, Italy Search for other works by this author on: Oxford Academic Google Scholar FULVIO ALLEGRA FULVIO ALLEGRA Istituto di Clinica Dermosifilopatica, Università degli Studi di Parma, Italy Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 100, Issue 4, 1 April 1979, Pages 427–432, https://doi.org/10.1111/j.1365-2133.1979.tb01644.x Published: 01 April 1979
Effect of sleep deprivation on brain metabolism of depressed patients
Authors: J C Wu, J C Gillin, M S Buchsbaum, T Hershey, J C Johnson, W E Bunney
Journal: American Journal of Psychiatry (1992)

Sleep deprivation is a rapid, nonpharmacologic antidepressant intervention that is effective for a subset of depressed patients. The objective of this study was to identify which brain structures' activity differentiates responders from nonresponders and to study how metabolism in these brain regions changes with mood.Regional cerebral glucose metabolism was assessed by positron emission tomography (PET) with [18F]deoxyglucose (FDG) before and after total sleep deprivation in 15 unmedicated awake patients with unipolar major depression and 15 normal control subjects, who did the continuous performance test during FDG uptake.After sleep deprivation, four patients showed a 40% or more improvement on the Hamilton Rating Scale for Depression. Before sleep deprivation the depressed responders had a significantly higher cingulate cortex metabolic rate than the depressed nonresponders, and this normalized after sleep deprivation. The normal control subjects and nonresponding depressed patients showed no change in cingulate metabolic rate after sleep deprivation.Overactivation of the limbic system as assessed by PET scans may characterize a subset of depressed patients. Normalization of activity with sleep deprivation is associated with a decrease in depression.
Abstract 1593: GSK3β mediated arsenite induction of spindle abnormalities
Authors: Tz-Chi Lin, Ren-Meei Chen, Hsiao-Hui Kuo, Ling-Huei Yih
Journal: Cancer Research (2014)

Abstract Arsenite induces centrosome amplification and spindle abnormalities, leading to chromosome missegregation and consequently resulting in mitotic cell apoptosis or aneuploidy. However, the underlying mechanism of how arsenite disrupts mitotic spindles is not known. In this study, we showed that CGL2 cells treated with arsenic trioxide (ATO) were arrested at mitotic stage in company with the formation of substantial spindle abnormalities and significant reduction of acetylated- and detyrosinated-tubulin, characteristics of decreased MT stability. Immunofluorescence staining of EB1, a plus-end microtubule-binding protein, revealed discrete EB1 spots distributing along microtubule (MT) nucleated from the two spindle poles in untreated mitotic cells. However, it showed a disorganized pattern in ATO-arrested mitotic cells with the spot-like EB1 clusters splashing all over the cells. In addition, immunoblotting and immunofluorescence staining revealed that the mitosis-specific inhibitory phospho-GSK3 was diminished in ATO-arrested mitotic cells. Pharmacological inhibition of GSK3 could prevent ATO induction of spindle abnormalities, mitotic arrest, and cell death. Since GSK3β has been reported to reduce MT stability by phosphorylating several microtubule-associated proteins, our current results indicated that GSK3β may mediate ATO induction of spindle abnormalities. Citation Format: Tz-Chi Lin, Ren-Meei Chen, Hsiao-Hui Kuo, Ling-Huei Yih. GSK3β mediated arsenite induction of spindle abnormalities. [abstract]. In: Proceedings of the 105th Annual Meeting of the American Association for Cancer Research; 2014 Apr 5-9; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2014;74(19 Suppl):Abstract nr 1593. doi:10.1158/1538-7445.AM2014-1593
A Push for Comparative Effectiveness
Authors: Bridget M. Kuehn
Journal: JAMA (2012)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal