CHRONIC SODIUM CHLORIDE TOXICITY: THE PROTECTIVE EFFECT OF ADDED POTASSIUM CHLORIDE
Authors: G R MENEELY, C O BALL, J B YOUMANS
Journal: Annals of Internal Medicine (1957)

Article1 August 1957CHRONIC SODIUM CHLORIDE TOXICITY: THE PROTECTIVE EFFECT OF ADDED POTASSIUM CHLORIDEG. R. MENEELY, M.D., F.A.C.P., C. O. T. BALL, J. B. YOUMANS, M.D., F.A.C.P.G. R. MENEELY, M.D., F.A.C.P., C. O. T. BALL, J. B. YOUMANS, M.D., F.A.C.P.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-47-2-263 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptEarly in our investigations of chronic sodium chloride toxicity, possible interrelations between dietary sodium and potassium came to our attention. There has been a good basis for suspecting such since 1843. At that time it was suggested, on the basis of direct chemical analysis, that the herbivores' need for salt and the occasion for their long journeys in search of it were due not to lack of sodium in the diet but to an excess of potassium. We drew attention to this in introductory remarks to our presentations before the September, 1952, meeting of the American Physiological Society.1, 2These...Bibliography1. MeneelyTuckerDarbyAuerbach GRRGWJSH: Hypertension, edema and renal failure produced in the rat by high salt diet, Proc. Am. Physiol. Soc., Am. J. Physiol. 171: 750, 1952. Google Scholar2. ThompsonMcQuarrie HWI: Effects of various salts on carbohydrate metabolism and blood pressure in diabetic children, Proc. Soc. Exper. Biol. and Med. 31: 907, 1933-34. CrossrefGoogle Scholar3. Meneely GR: Salt, Am. J. Med. 16: 1, 1954. CrossrefMedlineGoogle Scholar4. Meneely GR: The relation of sodium to congestive failure, Trans. Am. Coll. Cardiol. 4: 305, 1954. Google Scholar5. Priddle WW: Observations on the management of hypertension, Canad. M. A. J. 25: 5-8, 1931. MedlineGoogle Scholar6. MeneelyTuckerAuerbachDarby GRRGSHWJ: Renal damage in rats fed large quantities of sodium chloride, Proc. Am. Soc. Clin. Invest., J. Clin. Investigation 31: 650, 1952. Google Scholar7. MeneelyTuckerDarby GRRGWJ: Chronic sodium chloride toxicity in the albino rat. I. Growth on a purified diet containing various levels of sodium chloride, J. Nutrition 48: 489, 1952. CrossrefMedlineGoogle Scholar8. MeneelyTuckerDarbyAuerbach GRRGWJSH: Chronic sodium chloride toxicity in the albino rat. II. Occurrence of hypertension and a syndrome of edema and renal failure, J. Exper. Med. 98: 71, 1953. CrossrefMedlineGoogle Scholar9. MeneelyTuckerDarbyAuerbach GRRGWJSH: Chronic sodium chloride toxicity: hypertension, renal and vascular lesions, Ann. Int. Med. 39: 991, 1953. LinkGoogle Scholar10. TuckerDarbyAuerbachBallMeneely RGWJSHCOGR: Effect of dietary NaCl on the longevity of the albino rat, XIX, International Physiological Congress, Montreal, abstracts of communications, p. 838, 1953. Google Scholar11. MeneelyLemley-StoneTuckerBlakeAuerbachDarbyGoodpasture GRJRGTMSHWJEW: Chronic sodium chloride toxicity: the arteriosclerotic lesion, Proc. Am. Soc. for the Study of Arteriosclerosis, Circulation 12: 481, 1955. Google Scholar12. MeneelyDarbyLemley-StoneTuckerBall GRWJJRGCO: Survival of rats prolonged by adding potassium chloride to diets containing toxic levels of sodium chloride, Proc. Am. Physiol. Soc., Am. J. Physiol. 187: 617, 1956. Google Scholar13. Youmans JB: The chronic toxicity of salt (sodium chloride), The 1956 Jerome Cochran Lecture, Med. Assoc. State of Alabama J. 26: 161, 1957. MedlineGoogle Scholar14. TuckerBallDarbyEarlyKoryYoumansMeneely RGCOWJWRRCJBGR: Chronic sodium chloride toxicity in the albino rat. III. Maturity characteristics, survivorship and organ weights, J. Gerontol. 12: 182-189 (1957). CrossrefMedlineGoogle Scholar15. Tobian L: Tissue cations and water in arterial hypertension, Circulation 5: 754, 1952. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Nashville, Tennessee*Presented at the Thirty-eighth Annual Session of The American College of Physicians, Boston, Massachusetts, April 10, 1957.From the Radioisotope Service and the Research Laboratory, Thayer Veterans Administration Hospital, and the Departments of Medicine, Preventive Medicine and Public Health, and Biochemistry, Vanderbilt University School of Medicine, Nashville, Tennessee.The research reported was supported in part by the Life Insurance Medical Research Fund G-54-24 and the National Institutes of Health, H-1816.Requests for reprints should be addressed to George R. Meneely, M.D., Vanderbilt University School of Medicine, Nashville 5, Tenn. 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