tbuckley/cabot-search huggingface dataset:
Improving the Adverse Childhood Experiences Study Scale
Authors: David Finkelhor, Anne Shattuck, Heather Turner, Sherry Hamby
Journal: JAMA Pediatrics (2012)

To test and improve upon the list of adverse childhood experiences from the Adverse Childhood Experiences (ACE) Study scale by examining the ability of a broader range to correlate with mental health symptoms.Nationally representative sample of children and adolescents.Telephone interviews with a nationally representative sample of 2030 youth aged 10 to 17 years who were asked about lifetime adversities and current distress symptoms.Lifetime adversities and current distress symptoms.The adversities from the original ACE scale items were associated with mental health symptoms among the participants, but the association was significantly improved (from R2 = 0.21 to R2 = 0.34) by removing some of the original ACE scale items and adding others in the domains of peer rejection, peer victimization, community violence exposure, school performance, and socioeconomic status.Our understanding of the most harmful childhood adversities is still incomplete because of complex interrelationships among them, but we know enough to proceed to interventional studies to determine whether prevention and remediation can improve long-term outcomes.
Group Offers Advice on Safe Extraction of Lead Wires in Implantable Heart Devices
Authors: Mike Mitka
Journal: JAMA (2009)

cinations for nonmedical reasons. Because of the success of immunization, parents do not see the illness and death associated with these vaccinepreventable diseases and some are thus more likely to fear potential adverse effects of vaccination than the toll of the infections that the vaccines prevent, said Daniel A. Salmon, PhD, a coauthor of the Colorado study and vaccine safety specialist with the federal government’s National Vaccine Program in the Office of Public Health and Science. The public hears, for example, that some children have bad reactions to vaccines, do not develop immunity, or contract disorders that manifest themselves coincidentally following vaccination. These scenarios lead some parents to question the efficacy and safety of vaccines and to draw connections between immunization and increased risk of developing nonvaccination conditions. The changes in parents’ perceptions of disease pose a challenge for today’s vaccine programs, Salmon explained. Some parents believe there is a link between vaccination and autism, despite the numerous epidemiological studies that have failed to demonstrate such an association (Gerber JS and Offit PA. Clin Infect Dis. 2009;48[4]451-461 [http: //www.journals.uchicago.edu/doi/pdf /10.1086/596476]). Whatever the reason, choosing not to vaccinate has consequences because most vaccinepreventable diseases “are still around and reemerge when children are not vaccinated,” Salmon said. Paul A. Offit, MD, director of the Vaccine Education Center at the Children’s Hospital of Philadelphia, had hoped last year’s outbreak of Haemophilus influenzae type b (Hib) in 5 Minnesota children—3 of whom had not received the Hib vaccine because of parental refusal or delay—would provide the anecdotal weapon needed to convince reluctant parents to agree to vaccination. “I thought the tipping point would be the Hib cluster in Minnesota, but children are still dying,” Offit said. “People still fear the vaccine more than the disease.” The resolution of that fear most likely will come from discussions between parents and their children’s pediatricians, said Harry L. Keyserling, MD, a member of the Committee on Infectious Diseases of the American Academy of Pediatrics (AAP). To aid in the discussion, the AAP issued a clinical report offering guidance to practitioners responding to parents who refuse vaccination (Diekema DS et al. Pediatrics. 2005;115[5]:1428-1431). Keyserling, who is also a professor of pediatrics at Emory University School of Medicine in Atlanta, said some pediatricians become so frustrated with reluctant parents that they want to drop these children as patients. That, he said, would be wrong. “Many physicians are uncomfortable taking care of parental refusers, but there is always the opportunity for the parents to change their minds,” Keyserling said. “So at each visit, the issue needs to be brought up again.”
Association between prehypertension and chronic kidney disease in the Japanese general population
Authors: Yuichiro Yano, Shouichi Fujimoto, Yuji Sato, Tsuneo Konta, Kunitoshi Iseki, Toshiki Moriyama, Kunihiro Yamagata, Kazuhiko Tsuruya, Hideaki Yoshida, Koichi Asahi, Issei Kurahashi, Yasuo Ohashi, Tsuyoshi Watanabe
Journal: Kidney International (2011)
Renal Failure After Angiography
Authors: James F. Glenn
Journal: JAMA (1985)

<h3>To the Editor.—</h3> The report of renal dysfunction as a consequence of arteriography, by Dr Mason et al,<sup>1</sup>in the Feb 15 issue is outstanding. Transient impairment of renal function is a common complication of contrast studies, particularly in patients with surgical disease such as carcinoma of the kidney. When radical nephrectomy follows arteriographic studies by a day or two, renal failure may become manifest in the postoperative interval, complicating convalescence from major surgical intervention. Many believed that the degree of renal failure observed after arteriography was related to the total volume of contrast material employed in a given study. The authors did not observe such a correlation, but they do point out that multiple injections of contrast material apparently, irrespective of volume, will be more likely to predispose impairment of renal function. This is an extremely important observation. One additional factor is worthy of mention. In my experience,
ARTIFICIAL PNEUMOTHORAX IN THE TREATMENT OF BILATERAL CASES OF PULMONARY TUBERCULOSIS
Authors: HERBERT F. GAMMONS
Journal: JAMA (1918)

Erosive and gangrenous balanitis, the balano- posthite \l=e'\rosivecircin\l=e'\eof Berdal and Bataille,1 is a fairly uncommon affection, even in large venereal clinics, but its serious character when unrecognized entitles it to more frequent and extended notice in medical literature than it has received up to the present time.
TCT-694 Clinical And Angiographical Outcomes Of Percutaneous Coronary Intervention With Triple Kissing Balloon Technique After Drug-Eluting Stent Implantation For Left Main Trifurcation Disease
Authors: Shunsuke Kubo, Kazushige Kadota, Seiji Habara, Takeshi Tada, Hiroyuki Tanaka, Yasushi Fuku, Naoki Oka, Harumi Katoh, Tsuyoshi Goto, Kazuaki Mitsudo
Journal: Journal of the American College of Cardiology (2012)
Safety and clinical activity of the combination of 5-azacytidine, valproic acid, and all-trans retinoic acid in acute myeloid leukemia and myelodysplastic syndrome
Authors: Andres O. Soriano, Hui Yang, Stefan Faderl, Zeev Estrov, Francis Giles, Farhad Ravandi, Jorge Cortes, William G. Wierda, Souzanne Ouzounian, Andres Quezada, Sherry Pierce, Elihu H. Estey, Jean-Pierre J. Issa, Hagop M. Kantarjian, Guillermo Garcia-Manero
Journal: Blood (2007)

The combination of a DNA hypomethylating agent with a histone deacetylase inhibitor has synergistic antileukemia activity and may restore sensitivity to all-trans retinoic acid (ATRA). We conducted a phase 1/2 study of the combination of 5-azacitidine (5-AZA), valproic acid (VPA), and ATRA in patients with acute myeloid leukemia or high-risk myelodysplastic syndrome. 5-AZA was administered subcutaneously at a fixed dose of 75 mg/m2 daily for 7 days. VPA was dose-escalated and given orally daily for 7 days concomitantly with 5-AZA. ATRA was given at 45 mg/m2 orally daily for 5 days, starting on day 3. A total of 53 patients were treated. Their median age was 69 years (range, 5-84 years). The maximum tolerated dose of VPA in this combination was 50 mg/kg daily for 7 days. Dose-limiting toxicity was reversible neurotoxicity. The overall response rate was 42%. In previously untreated older patients, the response rate was 52%. Median number of courses to response was 1 (range, 1-3 courses). Median remission duration was 26 weeks, and median survival has not been reached. A significant decrease in global DNA methylation and induction of histone acetylation were achieved. VPA blood levels were higher in responders (P &lt; .005). In conclusion, the combination studied is safe and has significant clinical activity. This clinical trial was registered at www.clinicaltrials.gov as no. NCT00326170.
ATYPICAL SURGICAL MASTOIDITIS: REPORT OF A CASE
Authors: J. L. Johnson
Journal: JAMA (1923)

That surgical mastoiditis may be a grave menace, without any syndrome that would be apparent to a casual examiner, was recently shown by Phillips and Friesner.<sup>1</sup>My impression is that this is more apt to be found typically in adults than in children. The case here reported is, I feel, fairly representative of this condition. Also it is especially interesting from the standpoint of the duration of the process, which by history was three, and to my own observation two months. <h3>REPORT OF CASE</h3> R. J., aged 68, a farmer, seen first, Sept. 9, 1922, complained of deafness in the right ear. One month before he had experienced a sharp, sudden pain in the ear. The canal was washed with warm water, whereupon the pain ceased; but the patient had been deaf in the ear since that time. There had never since been any pain. There had never been
Failure of aerosolised 99mTc DTPA clearance to predict outcome in patients with adult respiratory distress syndrome.
Authors: D Royston, S Braude, K B Nolop
Journal: Thorax (1987)

The rate of clearance of technetium-99m labelled diethylene triamine pentacetic acid (99mTc DTPA) was measured in 32 patients with adult respiratory distress syndrome to determine if a more rapid clearance rate, possibly reflecting a more severe abnormality of pulmonary function, was associated with a reduced likelihood of recovery from pulmonary failure. Although the mean rate of clearance from lung to blood (T1/2LB) of 99mTc DTPA was more rapid in the patients (T1/2LB = 29 (SEM 3.2) min than in 42 normal subjects (T1/2LB = 59 (1.8)min), there was no difference between the clearance rate in the 18 patients who recovered from respiratory failure (T1/2LB = 31 (5) min) and the 14 who died (T1/2LB = 27 (4) min). Additionally, not all patients studied had abnormally rapid clearance rates. In 12 of the 32 patients the T1/2 fell within the range for normal individuals; this was found more commonly in patients who were predisposed to develop adult respiratory distress syndrome by pancreatitis or massive blood transfusion. These data suggest that a single measurement of 99mTc DTPA clearance in patients with established respiratory failure and adult respiratory distress syndrome is of no value in assessing the likelihood of recovery from this condition.
Directed differentiation of telencephalic precursors from embryonic stem cells
Authors: Kiichi Watanabe, Daisuke Kamiya, Ayaka Nishiyama, Tomoko Katayama, Satoshi Nozaki, Hiroshi Kawasaki, Yasuyoshi Watanabe, Kenji Mizuseki, Yoshiki Sasai
Journal: Nature Neuroscience (2005)
A CRITICAL STUDY OF THE ALBUMIN REACTION IN THE SPUTUM OF TUBERCULOUS PATIENTS
Authors: JAMES R. SCOTT
Journal: JAMA (1913)

The attention of the medical profession in the United States is being more and more directed toward a chemical study of the sputum in diseases of the respiratory tract, especially in an effort to discover easier and more reliable methods of accurately diagnosing some of these diseases. The trend of modern investigation was turned toward these channels by the pioneer work of the French school of physicians, and has since been continued by the laboratory workers of England and America. The chemical study of the sputum was begun in 1835 by a French physician, Biermier,1and his work was supplemented by his colleagues. One of the first results of this work was the discovery that albumin occurred in certain diseases of the respiratory tract and not in others. With this as a working basis, Roger and Levy-Valensi2attempted to discover the exact relationship between the presence of albumin
An immunofluorescent study of the distribution of immunoglobulin-containing cells in the normal and the inflamed human gall bladder
Authors: F. H. Y. Green, H. Fox
Journal: Gut (1972)

Immunoglobulin-containing cells are present in the normal human gall bladder but they are much less numerous in this site than in the normal intestine. IgA-containing cells predominate in the mucosa but in the muscle layer IgM cells are the more numerous. In both acute and chronic inflammation of the gall bladder there is a marked increase in the number of immunoglobulin-containing cells. In all but the most severe cases of inflammation it is those cells containing IgA which show the greatest increase in numbers, but in severe cases there is a disproportionate rise in the number of IgG- and IgM-containing cells, these latter being possibly derived from the blood. IgA cannot be demonstrated in the epithelial cells of the gall bladder and positive evidence of secretion into the bile of locally produced immunoglobulin is lacking. It is suggested that the concentration of IgA normally present in bile is such that, irrespective of local production, some is derived from the serum or the intestine.
Changes in Sucrase, Enterokinase, and Peptide Hydrolase after Intestinal Resection THE ASSOCIATION OF CELLULAR HYPERPLASIA AND ADAPTATION
Authors: Denis M. McCarthy, Young S. Kim
Journal: Journal of Clinical Investigation (1973)

In a study of changes in digestive enzymes after massive intestinal resection and the mechanisms by which such changes occur, rats were sacrified 4 wk after removal of the proximal two-thirds of the small intestine. Alterations in the mucosal levels of sucrase, enterokinase, and dipeptide hydrolase (L-leucyl-L-alanine substrate) were examined in the light of associated changes in protein. DNA and wet mucosal weight, measured in standardized gut segments from various regions of intestine. Metabolic studies showed that normal growth patterns were reestablished after the operation but significant elevations in stool weight and fecal nitrogen occurred in the second postoperative week, falling towards normal by the 4th wk. In standard gut segments wet weight of mucosa, protein, and DNA rose, especially in distal segments, DNA increasing disproportionately. Mucosal levels of the proximally distributed and membrane-bound enzymes, sucrase and enterokinase, showed similar patterns of change: when enzyme activity was expressed in terms of the total per segment, proximally there were considerable increases in both enzymes, but, expressed in terms of specific activity, that of sucrase fell and that of enterokinase was unaltered. By contrast, the largely soluble and more distally distributed dipeptide hydrolase increased more in distal segments and the increases in total activity were accompanied by lesser increases in specific activity. However, in spite of increases in total activity, enzyme activity per milligram DNA fell by over 50% in postanastomotic segments. Subcellular distribution studies showed no change in the percentage of the total activity which was membrane-bound and zymograms confirmed that no new dipeptide hydrolase had appeared after resection. It is concluded that increases in the segmental totals of various enzymes seen after resection are achieved by disproportinate increases in the number of mucosal cells per segment and that the greatest change in a particular enzyme occurs in the region where the enzyme is normally found in highest concentration.
Thiazolidinediones and Lowered HDL Cholesterol
Authors: Ruth L. Savage, Anne Kiuru
Journal: Diabetes Care (2005)

Three publications, including two recently in Diabetes Care, have indicated that a combination of rosiglitazone and fibrates may lower serum HDL cholesterol in some patients (1–3). It is known that a paradoxical fall in HDL cholesterol may occur with fibrates.

These series of cases include only one case of HDL cholesterol lowering in a patient taking rosiglitazone without a fibrate (1). There are no published case reports of this reaction occurring with other thiazolidinediones, where the reaction resolved when the latter, rather than the fibrate, was withdrawn. Thus, confirmatory evidence of this reaction occurring with rosiglitazone alone and whether it …
Paratyphoid in Man and Cattle
Authors: J. T. A. George, J. G. Wallace, H. R. Morrison, J. F. Harbourne
Journal: BMJ (1972)

Salmonella paratyphi B, phage type Taunton, caused generalized subclinical infection of cows and cases of human enteric fever at a dairy farm. The cattle were probably infected from a stream receiving the sewage effluent of a village in which a chronic carrier lived. At the same time as the farm outbreak a water-borne outbreak of human paratyphoid fever occurred in villages several miles away. The water supply was chlorinated and no failure of its treatment had been detected. S. paratyphi B, type Taunton, was isolated from the septic tank of a cottage near the water source and from soil over a break in the effluent pipe. Several inhabitants of the cottage worked at the infected dairy farm and one showed serological evidence of infection.Attention is drawn to the lack of statutory powers which could be applied to prevent the spread of the disease from the dairy herd and to the hazards of simple chlorination in the absence of additional safeguards of a water supply liable to pollution by surface water.
The placental growth factor as a target against hepatocellular carcinoma in a diethylnitrosamine-induced mouse model
Authors: Femke Heindryckx, Stephanie Coulon, Ellen Terrie, Christophe Casteleyn, Jean-Marie Stassen, Anja Geerts, Louis Libbrecht, Joke Allemeersch, Peter Carmeliet, Isabelle Colle, Hans Van Vlierberghe
Journal: Journal of Hepatology (2012)
A Balanced Diet?: Selenium May Offset the Effects of Methylmercury on Cataract Development
Authors: Naomi Lubick
Journal: Environmental Health Perspectives (2010)

Genotoxicity of Chemicals in Indoor Swimming PoolsDisinfection by-products (DBPs) form in swimming pool water from reactions between disinfectants such as chlorine and organic matter such as sweat, skin cells, and urine.A new study described in a set of three articles provides the first comprehensive characterization of DBPs in an indoor pool environment and offers initial evidence of cellular-level effects of these chemicals in swimmers in an indoor chlorinated pool [
Moonlighting House Officers
Authors: Arthur J. Moss
Journal: New England Journal of Medicine (1984)

Moonlighting by house officers is a continuing problem. Despite the importance some attach to it, it has received little more than token consideration in recent years. A review of the Index Medicus back to the year 1966, under the rubric "Interns and Residents," uncovered only nine communications on the subject: four editorials,1 2 3 4 four letters to the editor,5 6 7 8 and one article that only tangentially addressed moonlighting.9 The opinions expressed pro and con were purely speculative and derived from conviction rather than from data.Debate about this emotionally charged and controversial subject has been avoided for the most part by house officers . . .
Biodegradable injectable polyurethanes: Synthesis and evaluation for orthopaedic applications
Authors: Raju Adhikari, Pathiraja A. Gunatillake, Ian Griffiths, Lisa Tatai, Malsha Wickramaratna, Shadi Houshyar, Tim Moore, Roshan T.M. Mayadunne, John Field, Margaret McGee, Tania Carbone
Journal: Biomaterials (2008)
Topical benzoyl peroxide increases the sebum excretion rate
Authors: C. Pierard-Franchimont, P. Melotte, G.E. Pierard
Journal: British Journal of Dermatology (1984)

Journal Article Topical benzoyl peroxide increases the sebum excretion rate Get access C. Pierard‐Franchimont, C. Pierard‐Franchimont Department of Dermatology, CHU de Baviére, University of Liége, Bid. de la Constitution 66, B‐4020 Liege, Belgium Search for other works by this author on: Oxford Academic Google Scholar P. Melotte, P. Melotte Department of Dermatology, CHU de Baviére, University of Liége, Bid. de la Constitution 66, B‐4020 Liege, Belgium Search for other works by this author on: Oxford Academic Google Scholar G.E. Pierard G.E. Pierard Department of Dermatology, CHU de Baviére, University of Liége, Bid. de la Constitution 66, B‐4020 Liege, Belgium Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 110, Issue 4, 1 April 1984, Page 506, https://doi.org/10.1111/j.1365-2133.1984.tb04669.x Published: 01 April 1984
The allogeneic bisection of carrier-specific enhancement of monoclonal B-cell responses.
Authors: S K Pierce, N R Klinman
Journal: The Journal of Experimental Medicine (1975)

The ability of T cells to enhance the response of syngeneic and allogeneic B cells to thymus-dependent hapten-carrier conjugates was analyzed. This analysis was carried out on individual primary B cells in splenic fragment cultures derived from irradiated reconstituted mice. This system has several advantages: (a) the response of the B cells is entirely dependent on carrier priming of the irradiated recipient; (b) this B-cell response can be quantitated in terms of the number of responding cells; and (c) very small B-cell responses can be readily detected and analyzed. The results indicate that the majority of hapten-specific B cells were stimulated in allogeneic and syngeneic recipients only if these recipients were previously carrier primed. The number of B cells responding in carrier-primed allogeneic recipients was 60-70% of that in syngeneic carrier-primed recipients. The antibody-forming cell clones resulting from B cells stimulated in the allogeneic environment produced small amounts of antibody and antibody solely of the IgM immunoglobulin class, while the larger responses in syngeneic recipients were predominantly IgG1 or IgM plus IgG1. The capacity of collaborative interactions between carrier-primed T cells and primary B cells to yield IgG1 antibody-producing clones was shown to be dependent on syngeny between these cells in the H-2 gene complex. It is concluded that: (a) B cells can be triggered by T-dependent antigens to clone formation through collaboration with T cells which differ at the H-2 complex as long as these T cells recognize the antigen; (b) the immunoglobulin class produced by the progeny of stimulated B cells generally depends on the nature of the stimulatory event rather than the nature of the B cell itself; and (c) stimulation to IgG1 production is dependent on syngeny between the collaborating T and B cells probably within the Ir-1A region. The role of the Ia antigens in the formation of IgG1-producing clones is not yet clear; Ia identity could permit IgG1 production or, conversely, nonidentity of Ia could induce all allogeneic interactions which prohibit IgG1 production.