tbuckley/cabot-search huggingface dataset:
Tracheal resection for post-intubation tracheal stenosis
Authors: Fatih Candas, Akin Yildizhan, Nurettin Yiyit, Rauf Gorur, Turgut Isitmangil
Journal: European Respiratory Journal (2012)

Tracheal resection and reconstruction is required in some conditions, such as tumors, post-traumatic lesions. Post-intubation tracheal stenozis (PS) remain the most common indications for tracheal resection. The best treatment of PS is surcigal resection. We aim to evaluate our experience on patients with PS.  Between 2008-2011 seven patients underwent primary tracheal resection and reconstruction for PS. Six of the patient were male and one of the patient was female, with main age of twenty eight (range 21-75 years). Before the surgery, dilatation with rigid bronchoscopy was perform for two patients and a stent was inserted in one patient. A 1.5-4 cm tracheal segment resection and end-to-end anastomosis was applied.  Tracheal resection and end-to-end anastomosis caused good tracheal healing postoperatively. We had one tracheal air leak, one tracheal stenosis and one wound infection. Postoperative mortality was not observed. Patients who underwent tracheal resection and end-to-end anastomosis had a better airway on examination and were symptomatically improved in all cases (7/7).  The treatment of PS is well establihed and leads to high level of succes with minimally complication. Good results are obtained both with tracheal resection and end-to-end anastomosis, but restenosis remains a problem. Detailed preoperative assesment and preparation associated with good surgical results.  Good outcomes are achieved with both LTR and CTR. An individual approach is required for treatment of paediatric airway stenosis to achieve good final outcomes. The overall success rate has increased only marginally in our institution over the last 20 years.
Transcription factor Nr4a1 couples sympathetic and inflammatory cues in CNS-recruited macrophages to limit neuroinflammation
Authors: Iftach Shaked, Richard N Hanna, Helena Shaked, Grzegorz Chodaczek, Heba N Nowyhed, George Tweet, Robert Tacke, Alp Bugra Basat, Zbigniew Mikulski, Susan Togher, Jacqueline Miller, Amy Blatchley, Shahram Salek-Ardakani, Martin Darvas, Minna U Kaikkonen, Graham D Thomas, Sonia Lai-Wing-Sun, Ayman Rezk, Amit Bar-Or, Christopher K Glass, Hozefa Bandukwala, Catherine C Hedrick
Journal: Nature Immunology (2015)
Abstract P253: Genome-Wide Association Study of Electrocardiographic Left Ventricular Hypertrophy among Persons of European Ancestry: the Kaiser Permanente/UCSF GERA Cohort
Authors: Carlos Iribarren, Ling Shen, Alfred D Round, Edward McNulty, Peter M Okin, Neil Risch, Catherine Schaefer, Eric Jorgenson
Journal: Circulation (2014)

Electrocardiographic (ECG)-derived left ventricular hypertrophy (LVH) is a recognized phenotype of hypertensive target organ damage and an independent risk factor for cardiovascular disease morbidity and mortality, and has been shown to be 20 to 40% heritable. A major prior collaborative study (EchoGen) relied on echocardiography measurement of LVH. We report here the results of the first genome-wide association study of an ECG index of LVH, the Cornell voltage, in a large US, population-based cohort. The Kaiser Permanente/UCSF Genetic Epidemiology Research on Adult Health and Aging (GERA) Cohort enrolled 110,266 persons, of whom 84,760 (77%) were of European ancestry (EA). Twelve-lead ECGs (obtained as part of routine medical care) were available in 59% (n=52,423; 62% female, mean age ± SD, 62 ± 13 years) of EA members of the GERA cohort. For those with more than 1 ECG (75%), one was selected at random. We programmatically derived from the digital tracings the Cornell voltage as R in aVL plus S in V3 (in mV). Mean ± SD Cornell voltages were 1.39 ± 0.58 mV in men and 1.16 ± 0.55 mV in women. Genotypes were generated on 674,518 SNPs using a custom designed Affymetrix Axiom array, and imputation was conducted using the 1000 Genomes data as a reference set. We identified 10 genetic loci (nearest genes: NFIA, CRIM1, CCDC141, HAND1, VGLL2, CTNNA, TBX3, SIPA1L1, ZNF595, and PROCR) with genome-wide significant associations (p&lt;5*10 -8 ) with Cornell voltage as a continuous variable. Five of the loci (NFIA, CRIM1, HAND1, TBX3, and SIPA1L1) have previously been reported to influence QRS and PR intervals, while the other loci are novel. Interestingly, none of these loci were associated with left ventricular mass in the EchoGen consortium. Sex-specific analyses supported the association of these loci in both men and women; six loci were associated at a genome-wide significant level in these stratified analyses, including TBX3 and ZNF595 in both men and women, CCDC141, SIPA1L1, and PROCR in men, and VGLL2 in women, despite reduced sample sizes. These results may help elucidate both the biological and genetic basis of this clinically relevant phenotype.
Cell Interactions with Vascular Regenerative MAA‐Based Materials in the Context of Wound Healing
Authors: Alexandra Lisovsky, Michael Dean Chamberlain, Laura Anne Wells, Michael Vivian Sefton
Journal: Advanced Healthcare Materials (2015)

In diabetic patients the development of chronic non-healing wounds is a common complication. A methacrylic acid-based biomaterial is a vascular regenerative material that enhances diabetic healing without the use of cells or growth factors. The bioactive nature of this material is thought to be associated with its anionic charge or surface chemistry. Contact between the methacrylic acid-based biomaterial and tissue begins with protein (including complement) adsorption and is followed by interaction of the biomaterial with resident and infiltrating cells in the wound bed (e.g., macrophages and endothelial cells). This results in changes to their surface receptors to activate phosphorylation cascades that lead to differential activation of signalling pathways such as those involving osteopontin and sonic hedgehog. These changes modulate the phenotype of the cells in the wound bed, eventually improving vessel formation and wound healing. Understanding the molecular and cellular mechanisms will have broad implications for biomaterials, not just the methacrylic acid-based material, and will facilitate the advancement of regenerative biomaterials for diverse applications.
Increased risk of atopic asthma at school age among children with persistent high BMI
Authors: Petra Loid, Emma Goksör, Bernt Alm, Rolf Pettersson, Per Möllborg, Laslo Erdes, Nils Åberg, Göran Wennergren
Journal: European Respiratory Journal (2014)

Background : Childhood overweight has been associated with asthma development. However, the association appears to be complex with conflicting results, for example regarding a possible link to allergic disease. The aim of this study was to explore the relationship between body mass index, BMI, and school age asthma.   Methods : Data were obtained from a prospective, longitudinal study of children born in western Sweden. The parents answered questionnaires at 6 months and 1, 4.5 and 8 years of age. The response rate at 8 years was 80% of the questionnaires distributed (4,051/5,044), that is 71% of the families entering the study (4,051/5,654).   Results : In a multivariate, stratified analysis we found an independently increased risk of doctor-diagnosed asthma at school age among children with high BMI,  i.e.  85th percentile and above, both at 1 and at 8 years (OR 2.9, 95% CI 1.3-6.4). A high BMI (age and gender adjusted) only at 1 year or only at 8 years of age did not increase the risk of school age asthma.  In addition, a persistent high BMI was associated with significantly increased risk of atopic asthma (OR 4.7, 2.0- 10.9), but not of non-atopic asthma. The analyses were adjusted for gender, preterm birth, small/large for gestational age, maternal obesity, caesarean section, atopic heredity, farm childhood, neonatal antibiotic, smoking during pregnancy, breast-feeding, parental education, fish consumption in infancy and allergic manifestations in infancy.   Conclusion : Persistent high BMI during childhood independently increased the risk of doctor-diagnosed asthma at school age. The increased risk of atopic asthma, but not of non-atopic asthma, suggests an effect mediated via the immune system.
Screening for intracranial aneurysms
Authors: J. Rowe, S. Renowden, T. Cadoux-Hudson
Journal: BMJ (1995)

EDITOR,--Since migraine without aura aggregates in families of probands with migraine without aura, it is expected that migraine without aura is less common in families of probands who have never had migraine. We calculated the population relative risk, adjusting for sex and age, since migraine without aura depends on these factors. If the population relative risk significantly exceeds one an increased family aggregation is implied, whereas a result significantly below one implies a decreased family aggregation.

W E Waters states that the risk of migraine without aura among the first degree relatives …
Is hyaluronic acid (HA) a marker of effectiveness of anti-inflammatory therapy in COPD patients?
Authors: Bogdana Basina, Tetyana Pertseva, Lyudmyla Konopkina
Journal: European Respiratory Journal (2013)

HA is considered by some researchers as one of the markers of inflammation in COPD patients.

Aim: to study the diagnostic value of HA in COPD patients and the role of the HA as a marker of the effectiveness of anti-inflammatory therapy in COPD pstients.

Materials and methods: we studied 51 COPD patients with III stages (FEV1 - 48,39±1,8 % pred), which formed a main group (age - 62,2±1,1 yrs), which are either accepted anti-inflammatory therapy (inhaled glucocorticosteroids (IGCS)) variably or did not take it according to the stage of the disease. The patients were examined twice: at visit 1 - to correct treatment, and at visit 2 - after 3 months after correction of treatment. Measurements included clinical status, spirometry, plasma level of HA.

The control group consisted of 13 healthy individuals (age - 53,2±2,8 yrs).

Results: we found that on visit 1 the level of HA in main group was significantly higher than in patients of the control group (0,21±0,01 ng/ml comparing to 0,15±0,01 ng/ml) (p<0,05). At visit 2 HA level decreased significantly in all patients comparing to this one on visit 1, it’s average rate was 0,16 ng/ml (p<0,05), which corresponded to the level of the control group.

Conclusion: the significant decreasing of HA level in COPD patients may be a marker of the effectiveness of anti-inflammatory therapy.
Depressed Chemotactic Responses In Vitro of Peritoneal Macrophages From Tumor-Bearing Mice2
Authors: Mary M. Stevenson, Monte S. Meltzer
Journal: JNCI Journal of the National Cancer Institute (1976)

The in vitro chemotactic responses of peritoneal macrophages from mice bearing transplantable syngeneic 3-methylcholanthrene-induced tumors in their footpads were depressed to about 50% of normal levels. This chemotactic defect to both lymphocyte- and complement-derived stimuli was evident before the appearance of palpable tumor (within 1 week of tumor injection) and persisted until the death of the animal by 6-8 weeks. Chemotactic depression was not observed with macrophages from mice treated with tissue culture medium, fetal calf serum, incomplete Freund's adjuvant, or syngeneic spleen cells.
Haemophilus influenza related respiratory infections and hospital re-admissions
Authors: Rajesh Yadavilli, Rosalind Benson, Vinay Shanker Sreeguru Lakshman, Elizah Matovu, Sanjeev Agarwal
Journal: European Respiratory Journal (2013)

Introduction: 

Haemophilus Influenza (HI) is a virulent organism that commonly colonise patients with chronic lung diseases and cause respiratory illness in the form of pneumonia, exacerbation of chronic lung diseases and acute bronchitis. Inadequately treated HI infection can lead to recurrent hospital admission.

Hypothesis: 

HI sensitive antibiotics administered for >7 days result in fewer hospital readmissions within 30 days.

Methods: 

HI isolated from the sputum in hospitalised adult patients were identified over a 2 year period (Jan 2010 to Dec 2011). Association of readmissions with duration of treatment and sensitive antibiotics were studied.

Results: 

Total No of patients-150; No of admissions-277; HI related Readmissions-128; Respiratory co-morbidities - 83% (COPD -76%, Bronchiectasis - 5%, Asthma - 7%, Combined -8%).

52/128 readmissions were admitted within 30 days from hospital discharge.

Patients treated and discharged on HI resistant antibiotics had resulted in more hospital readmissions 23/35(66%) compared to treated and discharged on HI sensitive antibiotics 105/242(43%).P=0.017, Fisher’s exact test.

Duration of antibiotics administered for   7days 27/82(33%). P=0.024, Fisher’s exact test.

Conclusions: 

This study confirms the importance of treating HI with sensitive antibiotics. It would be urged to check sputum sensitivity on each admission to guide the management of HI with sensitive antibiotics especially in patients with recurrent admissions.

Antibiotics administered more than 7 days reduced readmissions in this study and we recommend 7 days should be the minimum duration of treatment for HI.
The Role of Transplant in Multiple Myeloma
Authors: Matthew Mei, George Somlo
Journal: Journal of the National Comprehensive Cancer Network (2014)

Over the past decades significant therapeutic advances have been made in the treatment of multiple myeloma (MM). A population-based study of 45,595 patients showed substantial incremental increases in myeloma-specific survival in patients younger than 80 years treated between 1973 and 2009. Depth of response to therapy has long been associated with improved long-term outcomes. Autologous stem cell transplantation (ASCT) was previously the only modality capable of inducing a very good partial response (VGPR) or complete response in a substantial proportion of patients. The introduction of 2 classes of novel agents, immunomodulatory drugs and proteasome inhibitors, resulted in induction regimens that achieve VGPR rates exceeding 60% even before transplant, thus challenging the role of ASCT. Allogeneic stem cell transplantation (allo-SCT) has also been tested in patients with MM; however, its current role remains undefined given the high rates of transplant-related mortality and chronic graft-versus-host disease. Posttransplant consolidation and maintenance strategies have further improved progression-free and overall survivals. This article discusses the current roles of ASCT, allo-SCT, and consolidation and maintenance therapies in the management of MM.
Evidence That B-Lymphocytes Carry the Nuclear Pocket Abnormality Associated With Bovine Leukemia Virus Infection: Brief Communication2
Authors: Kem A. Pomeroy, Prem S. Paul, Alvin F. Weber, Dale K. Sorensen, Donald W. Johnson
Journal: JNCI Journal of the National Cancer Institute (1977)

Journal Article Evidence That B-Lymphocytes Carry the Nuclear Pocket Abnormality Associated With Bovine Leukemia Virus Infection: Brief Communication Get access Kem A. Pomeroy, Kem A. Pomeroy Search for other works by this author on: Oxford Academic PubMed Google Scholar Prem S. Paul, Prem S. Paul Search for other works by this author on: Oxford Academic PubMed Google Scholar Alvin F. Weber, Alvin F. Weber Search for other works by this author on: Oxford Academic PubMed Google Scholar Dale K. Sorensen, Dale K. Sorensen Search for other works by this author on: Oxford Academic PubMed Google Scholar Donald W. Johnson Donald W. Johnson Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 59, Issue 1, July 1977, Pages 281–283, https://doi.org/10.1093/jnci/59.1.281 Published: 01 July 1977 Article history Received: 04 November 1976 Accepted: 25 January 1977 Published: 01 July 1977
Phase I trial of interferon gamma to potentiate cyclosporine-induced graft-versus-host disease in women undergoing autologous bone marrow transplantation for breast cancer.
Authors: M J Kennedy, G B Vogelsang, R J Jones, E R Farmer, A D Hess, V Altomonte, A M Huelskamp, N E Davidson
Journal: Journal of Clinical Oncology (1994)

PURPOSE We investigated if interferon gamma (IFN-gamma) could augment cyclosporine (CSA)-induced graft-versus-host disease (GVHD) following autologous bone marrow transplant in women with metastatic breast cancer and defined the toxicities of this therapy. PATIENTS AND METHODS Thirty-six women with advanced breast cancer were treated with CSA 2.5 mg/kg daily for 28 days and IFN-gamma 0.025 mg/m2 subcutaneously (SC) every other day, days 7 to 28 following autologous bone marrow transplantation and monitored for induction and severity of GVHD and toxicity of therapy. RESULTS GVHD was induced in 56% of patients. The severity of GVHD was greater than in a historic control population treated with CSA alone. Stage III rash was seen in 36% of patients, compared with 3% in the historic control population. Fourteen of 36 patients required therapy with topical corticosteroids and two of 36 required systemic treatment. Only three of 31 historic controls needed topical corticosteroids and no patient was treated systemically. There was no severe visceral GVHD. Hematopoietic recovery was not delayed. There were three toxic deaths. CONCLUSION CSA-induced GVHD can be safely augmented by IFN-gamma in women treated with high-dose alkylating agents and autologous bone marrow transplantation. There is little evidence of increased toxicity. Evidence of antitumor efficacy awaits further investigation.
Absorption and Protein Binding of N-2-Fluorenylacetamide and Its Metabolites in the Bladder of the Rabbit2
Authors: Martin L. Hopp, Michio Matsumoto, Chung Lee, Ryoichi Oyasu
Journal: JNCI Journal of the National Cancer Institute (1977)

Journal Article Absorption and Protein Binding of N-2-Fluorenylacetamide and Its Metabolites in the Bladder of the Rabbit Get access Martin L. Hopp, Martin L. Hopp Search for other works by this author on: Oxford Academic PubMed Google Scholar Michio Matsumoto, Michio Matsumoto Search for other works by this author on: Oxford Academic PubMed Google Scholar Chung Lee, Chung Lee Search for other works by this author on: Oxford Academic PubMed Google Scholar Ryoichi Oyasu Ryoichi Oyasu 6 6Address reprint requests to Dr. Ryoichi Oyasu. Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 58, Issue 2, February 1977, Pages 281–285, https://doi.org/10.1093/jnci/58.2.281 Published: 01 February 1977 Article history Received: 06 January 1976 Accepted: 14 June 1976 Published: 01 February 1977
Management for Doctors: Analysing your organisation and environment and setting its strategy
Authors: J. S M Zorab, A. Lloyd
Journal: BMJ (1995)

With regard to other recommended information, it would be particularly helpful if more employers could set interview dates in advance (in this study only 60/o of advertisements gave an interview date).This would facilitate the planning of locum cover.It would also be useful if employers could give a contact name for inquiries, preferably someone who could provide useful information about the post.Only 18% of advertisements gave a medical name as a contact in this survey, although this was much more common in psychiatry than other specialties.The content of the advertisements did not otherwise seem to be affected by grade or specialty of the post or by employer.When the unified training grade is introduced as a result of the Calman report2 junior doctors will usually seek one long rotation as a specialist trainee, rather than having to change jobs several times as the current system requires.Matching the right doctor to the right training programme will become even more important for both employer and trainee as the two will usually be linked for five or more years.It would therefore help to include more information in advertisements for specialist training programmes.Although certain specialties and geographical areas find it difficult to recruit suitable junior doctors, few employers seem to construct advertisements that are designed to attract applicants.Those writing adver- tisements for doctors in a training grade might wish to review their practice in relation to the BMA guidelines.More informative advertisements may attract more job applicants.
Early antiretroviral therapy in children perinatally infected with HIV: a unique opportunity to implement immunotherapeutic approaches to prolong viral remission
Authors: Nigel Klein, Paolo Palma, Katherine Luzuriaga, Savita Pahwa, Eleni Nastouli, Diane M Gibb, Pablo Rojo, William Borkowsky, Stefania Bernardi, Paola Zangari, Vincent Calvez, Alexandra Compagnucci, Britta Wahren, Caroline Foster, María Ángeles Munoz-Fernández, Anita De Rossi, Jintanat Ananworanich, Deenan Pillay, Carlo Giaquinto, Paolo Rossi
Journal: The Lancet Infectious Diseases (2015)
Plerixafor+G-CSF–mobilized CD34+ cells represent an optimal graft source for thalassemia gene therapy
Authors: Garyfalia Karponi, Nikoletta Psatha, Carsten Werner Lederer, Jennifer Eileen Adair, Fani Zervou, Nikolaos Zogas, Marina Kleanthous, Constantinos Tsatalas, Achilles Anagnostopoulos, Michel Sadelain, Isabelle Rivière, George Stamatoyannopoulos, Evangelia Yannaki
Journal: Blood (2015)
Inhibition of Cancer Cell Migration by Multiwalled Carbon Nanotubes
Authors: Lorena García‐Hevia, Rafael Valiente, José L. Fernández‐Luna, Emmanuel Flahaut, Lidia Rodríguez‐Fernández, Juan C. Villegas, Jesús González, Mónica L. Fanarraga
Journal: Advanced Healthcare Materials (2015)

Inhibiting cancer cell migration and infiltration to other tissues makes the difference between life and death. Multiwalled carbon nanotubes (MWCNTs) display intrinsic biomimetic properties with microtubules, severely interfering with the function of these protein filaments during cell proliferation, triggering cell death. Here it is shown MWCNTs disrupt the centrosomal microtubule cytoskeletal organization triggering potent antimigratory effects in different cancer cells.
Absorbable bioprosthesis for the treatment of bile duct injury in an experimental model
Authors: Eduardo E. Montalvo-Javé, Germán E. Mendoza Barrera, Alan I. Valderrama Treviño, María C. Piña Barba, César Montalvo-Arenas, Fernando Rojas Mendoza, Benjamin León Mancilla, Manuel A. García Pineda, Álvaro Jaime Limón, Jorge Albores Saavedra, Jesús Tapia-Jurado
Journal: International Journal of Surgery (2015)
The Cytokine GM-CSF Drives the Inflammatory Signature of CCR2+ Monocytes and Licenses Autoimmunity
Authors: Andrew L. Croxford, Margit Lanzinger, Felix J. Hartmann, Bettina Schreiner, Florian Mair, Pawel Pelczar, Björn E. Clausen, Steffen Jung, Melanie Greter, Burkhard Becher
Journal: Immunity (2015)
Genome Wide-Association Study Identifies Il28B Polymorphism to Be Associated with Baseline Alt and Hepatic Necro-Inflammatory Activity in Chronic Hepatitis C Patients Enrolled in the Ideal Study
Authors: Alexander J. Thompson, Paul J. Clark, Mingfu Zhu, Qianqian Zhu, Dongliang Ge, Mark S. Sulkowski, Andrew J. Muir, Hans L. Tillmann, Keyur Patel, Susanna Naggie, Nezam H. Afdhal, Ira M. Jacobsons, Rafael Esteban, Fred Poordad, Eric Lawitz, Jonathan McCone, Mitchell L. Shiffman, Greg Wayne Galler, John W. King, Paul Y. Kwo, Lisa Marie Nyberg, Zachary Goodman, Stephanie Noviello, Navdeep Boparai, Kenneth J. Koury, Lisa Pedicone, Clifford Brass, Janice K. Albrecht, David B. Goldstein, John G. McHutchison
Journal: Hepatology (2010)