tbuckley/cabot-search huggingface dataset:
Steps toward categorizing motivation: Abilities, limitations, and conditional constraints
Authors: Valerie A. Kuhlmeier, Susan A. J. Birch
Journal: Behavioral and Brain Sciences (2005)

Tomasello et al. have not characterized the motivation underlying shared intentionality, and we hope to encourage research on this topic by offering comparative paradigms and specific empirical questions. Although we agree that nonhuman primates differ greatly from us in terms of shared intentionality, we caution against concluding that they lack all aspects of it before other empirical tools have been exhausted. In addition, identifying the conditions in which humans spontaneously engage in shared intentionality, and the conditions in which we fail, will more fully characterize this ability.
Assignment of an autosomal sex reversa– locus (SRA1) and campomelic dysplasia (CMPD1) to 17q24.3–q25.1
Authors: N. Tommerup, W. Schempp, P. Meinecke, S. Pedersen, L. Bolund, C. Brandt, C. Goodpasture, P. Guldberg, K.R. Held, H. Reinwein, O.D. Saugstad, G. Scherer, O. Skjeldal, R. Toder, J. Westvik, C.B. van der Hagen, U. Wolf
Journal: Nature Genetics (1993)
Stage-Specific Impact of Tumor Location on Oncologic Outcomes in Patients With Upper and Lower Tract Urothelial Carcinoma Following Radical Surgery
Authors: Michael Rink, Behfar Ehdaie, Eugene K. Cha, David A. Green, Pierre I. Karakiewicz, Marko Babjuk, Vitaly Margulis, Jay D. Raman, Robert S. Svatek, Harun Fajkovic, Richard K. Lee, Giacomo Novara, Jens Hansen, Siamak Daneshmand, Yair Lotan, Wassim Kassouf, Hans-Martin Fritsche, Armin Pycha, Margit Fisch, Douglas S. Scherr, Shahrokh F. Shariat
Journal: European Urology (2012)
Floods Carry Potential for Toxic Mold Disease
Authors: Charles Marwick
Journal: JAMA (1997)

MOLD GROWTH in water-damaged homes is a potential hazard from spring flooding. Health officials in Ohio are already familiar with a toxic mold that has been linked to life-threatening pulmonary hemorrhage in infants younger than 1 year in Cleveland. The mold,<i>Stachybotrys atra</i>, may be found in houses affected by major water damage. "Unless the water damage is properly cleaned up, the recent floods in the midwest may provide an ideal opportunity for the growth of fungi. The<i>Stachybotrys</i>fungus seems to need a lot of water to grow," noted Ruth A. Etzel, MD, an epidemiologist in the Division of Environmental Hazards and Health Effects at the Centers for Disease Control and Prevention (CDC), Atlanta, Ga. "But," she said, "it's not just a matter of drainage. If carpeting has been soaked there's almost no way to get the water out of it. It has to be pulled up and thrown
Germline RECQL mutations are associated with breast cancer susceptibility
Authors: Cezary Cybulski, Jian Carrot-Zhang, Wojciech Kluźniak, Barbara Rivera, Aniruddh Kashyap, Dominika Wokołorczyk, Sylvie Giroux, Javad Nadaf, Nancy Hamel, Shiyu Zhang, Tomasz Huzarski, Jacek Gronwald, Tomasz Byrski, Marek Szwiec, Anna Jakubowska, Helena Rudnicka, Marcin Lener, Bartłomiej Masojć, Patrica N Tonin, Francois Rousseau, Bohdan Górski, Tadeusz Dębniak, Jacek Majewski, Jan Lubiński, William D Foulkes, Steven A Narod, Mohammad R Akbari
Journal: Nature Genetics (2015)
Inguinal Hernia: Operative Reinforcement
Authors: A. Simpson-Smith
Journal: BMJ (1939)

Suirgeoni to Out-patienits, West Lonidon Hospital Max Page (1934) stated that the recurrence rate in inguinal hernia was far greater than previously admitted, and in healthy metropolitan policemen, whose average age ,was 32, the rate amounted to 20.2 per cent. in indirect and 25.8 per cent. in direct varieties.Since this paper several carefully examined series of cases supporting Page's view have been published.Grace and Johnson (1937) record 1,032 cases, all over 50, with a recurrence rate of 25.8 per cent., Birkenfeld (1933) gives 28.49 per cent., Lyle (1928) 10.3 per cent., Fallis (1936) 8.25 per cent., andBlock (1933), in 642 cases personally followed for two years, 34.8 per cent.Fascia sutures have been of great service in repairing wide hernias, but even this method is not without defect, for Burdick et al. (1937) admit 29.1 per cent. of failures in a series of 975 fascial repairs.In addition, it is tedious and time-consuming to use this material.Ogilvie and Maingot (Maingot, 1937) have employed heavy floss silk loosely woven across the posterior wall of the canal to form a lattice.They claim that the minute fibres consti- tuting the silk cords are readily absorbed, provoke little reaction, and have no tendency to encourage sepsis.
Time to get smart about IT
Authors: Kinesh Patel
Journal: BMJ (2011)

Imagine an organisation that knows what you like, what you don’t like, where you live, where you shop, and how much you spend. Imagine all these data held on a central database, accessible from thousands of locations around the country by unknown operators at their whim.

It sounds scary written down; even ominous. Yet this is exactly the information loyalty cards such as the Tesco Clubcard or Nectar card provides.

Are most people bothered by this? Quite the contrary. Most people seem happy to allow these data to be collected about …
Mutations in the PCNA-binding domain of CDKN1C cause IMAGe syndrome
Authors: Valerie A Arboleda, Hane Lee, Rahul Parnaik, Alice Fleming, Abhik Banerjee, Bruno Ferraz-de-Souza, Emmanuèle C Délot, Imilce A Rodriguez-Fernandez, Debora Braslavsky, Ignacio Bergadá, Esteban C Dell'Angelica, Stanley F Nelson, Julian A Martinez-Agosto, John C Achermann, Eric Vilain
Journal: Nature Genetics (2012)
Myocardial relaxation and passive diastolic properties in man.
Authors: A Pasipoularides, I Mirsky, O M Hess, J Grimm, H P Krayenbuehl
Journal: Circulation (1986)

We have developed a model for assessing the influence of the decaying contractile systolic tension on diastolic wall dynamics and the passive properties of left ventricular muscle. Total measured left ventricular diastolic pressure and stress (sigma T) are determined by two overlapping processes: the decay of actively developed pressure and stress (sigma A) and the buildup of passive filling pressure and stress (sigma*). The decaying contractile stress sigma A is formulated in terms of a relaxation pressure with a time constant (T) assessed during the isovolumic relaxation interval. By subtracting the contribution of sigma A from sigma T we obtain sigma*. With micromanometry, echocardiography, and cineangiography, total and passive stress-strain relations and strain rates were evaluated over the entire filling period in six normal control subjects and in seven patients with aortic stenosis. Elastic stiffness constants (k), the slopes of the linear passive stiffness vs sigma* relations, did not differ in the two groups over a common lower stress range (6/6 normal, k = 9.37 +/- 1.23; 7/7 aortic stenosis, k = 9.34 +/- 1.08). Over a higher sigma* range, transition into a much steeper linear region occurred, and k values were much larger (4/7 aortic stenosis, k = 28.76 +/- 2.02). When diastolic stress levels are elevated, passive stiffness-stress relations can be better described as bilinear, with a much greater wall stiffness constant in the higher than in the lower stress range. Dynamic effects of decaying systolic contractile wall stress components are important in the rapid filling phase in normal hearts as well as in those with aortic stenosis.
A 62-Year-Old Woman With Chronic Obstructive Pulmonary Disease
Authors: Bartolome R. Celli
Journal: JAMA (2003)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Journals JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Heart Failure in Outpatients
Authors: Daniel Chia-Sen Lee, Robert Arnold Johnson, John B. Bingham, Marianne Leahy, Robert E. Dinsmore, Allan H. Goroll, John B. Newell, H. William Strauss, Edgar Haber
Journal: New England Journal of Medicine (1982)

The view that digitalis clinically benefits patients with heart failure and sinus rhythm lacks support from a well-controlled study. Using a randomized, double-blind, crossover protocol, we compared the effects of oral digoxin and placebo on the clinical courses of 25 outpatients without atrial fibrillation. According to a clinicoradiographic scoring system, the severity of heart failure was reduced by digoxin in 14 patients; in nine of these 14, improvement was confirmed by repeated trials (five patients) or right-heart catheterization (four patients). The other 11 patients had no detectable improvement from digoxin. Patients who responded to digoxin had more chronic and more severe heart failure, greater left ventricular dilation and ejection-fraction depression, and a third heart sound. Multivariate analysis showed that the third heart sound was the strongest correlate of the response to digoxin (P less than 0.0001). These data suggest that long-term digoxin therapy is clinically beneficial in patients with heart failure unaccompanied by atrial fibrillation whose failure persists despite diuretic treatment and who have a third heart sound.
Orthopaedics in Primary Care
Authors: Jon Divine
Journal: Annals of Internal Medicine (1998)

Medical Writings1 April 1998Orthopaedics in Primary CareJon Divine, MDJon Divine, MDBaylor College of Medicine, Houston, Texas.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-128-7-199804010-00038 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail Barr AJ, Harnden A; eds. 230 pages. Boston: Butterworth-Heinemann; 1997. $50.00. ISBN 0750622199. Order phone 800-366-2665.Field of medicine: Primary care with an emphasis on musculoskeletal medicine.Format: Softcover book.Audience: Primary care physicians; primary care and orthopedic residents; medical students; and allied health providers, such as physical therapists and athletic trainers.Purpose: To describe common and important orthopedic problems in the context of a primary care setting.Content: This concise, well-illustrated text describes common musculoskeletal injuries and problems. Each chapter is devoted to joint-specific problems and examination techniques. Along with important history and examination findings, problem-specific sections on differential ... Author, Article, and Disclosure InformationAffiliations: Baylor College of Medicine, Houston, Texas. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 April 1998Volume 128, Issue 7Page: 611KeywordsExerciseExercise therapyHealth care providersMusculoskeletal injuryOrthopedicsPatientsPrimary carePrimary care physiciansSportsSports and exercise medicine ePublished: 15 August 2000 Issue Published: 1 April 1998 Copyright & PermissionsCopyright © 1998 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Incidental Detection of Rupture of Substitute Urinary Bladder on Bone Scan
Authors: Kazuhiro Yamanouchi, Hiroshi Toyama, Takahiro Maruyama, Kiyotaka Hoshinaga, Kazuhiro Katada
Journal: Clinical Nuclear Medicine (2013)

We report here a case of rupture of a substitute urinary bladder due to a relapse of bladder cancer detected incidentally on a bone scan. The radionuclides used in bone scans accumulate in the bone and are excreted in the urine. Incidental detection of rupture of a substitute urinary bladder may lead to appropriate intermediate neobladder repair.
Abstract 3463: Treatment of young children with localized medulloblastoma by chemotherapy alone: Final results of the prospective multicenter trial HIT 2000 confirming the prognostic impact of histology
Authors: Andre O. von Bueren, Katja von Hoff, Torsten Pietsch, Nicolas Gerber, Monika Warmuth-Metz, Frank Deinlein, Isabella Zwiener, Andreas Faldum, Gudrun Fleischhack, Martin Benesch, Juergen Krauss, Joachim Kuehl, Rolf D. Kortmann, Stefan Rutkowski
Journal: Cancer Research (2011)

Abstract Background: This study was designed to confirm the previously observed favorable survival rates and prognostic factors in young children with non-metastatic medulloblastoma (MB) treated by postoperative chemotherapy alone. Methods: Patients diagnosed between January 2001 and December 2005 and younger than 4 years received three cycles of postoperative systemic multiagent chemotherapy and intraventricular methotrexate. In case of complete remission, treatment was terminated after two additional cycles of chemotherapy. Otherwise secondary surgery, radiotherapy and consolidation chemotherapy were recommended. Results: The 5-year event-free survival (EFS) and overall survival (OS) (±SE) rates of 45 patients were 57 ± 8% and 80 ± 6% (median follow-up: 4.5 years, median age: 2.5 years). Nineteen patients with desmoplastic / nodular MB variants had better EFS and OS (5-year rates: 90 ± 7% and 100 ± 0%) compared to 23 patients with classic MB (30 ± 11% and 68 ± 10%; p&amp;lt; 0.001 for EFS, p=0.008 for OS). Five-year EFS and OS rates of 3 children with anaplastic MB were 33 ± 27%. Desmoplastic / nodular histology was an independent prognostic factor for EFS. Twenty-nine of 30 (97%) patients without postoperative residual tumor remained in continuous complete remission. Conclusions: Our results confirm histology of MB variants as a strong prognostic factor in this age-group. Sustained tumor control and favorable survival rates can be achieved by this chemotherapy regimen in young children with desmoplastic / nodular MB variants. For children with non-desmoplastic / non-nodular MB variants, where predominantly local relapses lead to less favorable survival rates, local radiotherapy has been introduced after chemotherapy since 2006. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 102nd Annual Meeting of the American Association for Cancer Research; 2011 Apr 2-6; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2011;71(8 Suppl):Abstract nr 3463. doi:10.1158/1538-7445.AM2011-3463
Abstract LB-97: A novel anticancer bispecific antibody targeting VEGF and Dll4 inhibits tumor progression in lung and gastric cancer xenograft models
Authors: Weon-Kyoo You, Dongheon Lee, Yu Bin Choi, Kyung Jae Kang, Dong In Kim, Jin-Hyung Ahn, Jinwon Jung, Eun-Sil Sung, Jun Seo Goo, Hyun Sook Jang, Kyung Duk Moon, Sang Hooon Lee
Journal: Cancer Research (2014)

Abstract Several angiogenesis inhibitors targeting the vascular endothelial growth factor (VEGF) signaling pathway have been used for cancer treatment. However, VEGF inhibitors alone can promote tumor invasion and metastasis by increase of intratumoral hypoxia in some preclinical models. Emerging reports regarding angiogenesis suggest Delta-like-ligand 4 (Dll4) is a promising target to augment the effects of VEGF inhibitors. Dll4 blockade inhibits tumor progression by increasing nonproductive angiogenesis whereas VEGF blockade inhibits tumor progression by decreasing angiogenesis. To evaluate the effect by inhibiting both VEGF and Dll4 on tumor angiogenesis, we have developed HD105, a novel bispecific antibody targeting VEGF and Dll4, as the format of VEGF-binding IgG linked with Dll4-binding single-chain Fv. The bispecific antibody showed potent binding affinity against VEGF (KD: 3.4 x 10-12 M) and Dll4 (KD: 4.2 x 10-8 M), which are comparable with KD values of anti-VEGF antibody (9.8 x 10-10 M) and Dll4 single targeting antibody (5.5 x 10-9 M). The HD105 bispecific antibody also inhibited interaction of Dll4 and its receptor, Notch 1 (IC50: 1 nM ± 0.2). By using in vitro cell-based assays, the HD105 effectively blocked Dll4 as well as VEGF signaling pathways in endothelial cells, resulting in downregulation of Notch intracellular domain (NICD) and VEGFR-2/extracellular-signal-regulated kinase (ERK) phosphorylation. In addition, the HD105 more efficiently inhibited tumor progression than each single-targeting antibody in A549 human lung cancer and SCH human gastric cancer xenograft models. In conclusion, the novel bispecific antibody could be potentially developed as a clinically more efficacious therapeutic antibody. Citation Format: Weon-Kyoo You, Dongheon Lee, Yu Bin Choi, Kyung Jae Kang, Dong In Kim, Jin-Hyung Ahn, Jinwon Jung, Eun-Sil Sung, Jun Seo Goo, Hyun Sook Jang, Kyung Duk Moon, Sang Hooon Lee. A novel anticancer bispecific antibody targeting VEGF and Dll4 inhibits tumor progression in lung and gastric cancer xenograft models. [abstract]. In: Proceedings of the 105th Annual Meeting of the American Association for Cancer Research; 2014 Apr 5-9; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2014;74(19 Suppl):Abstract nr LB-97. doi:10.1158/1538-7445.AM2014-LB-97
Stroke Recovery Improved
Authors: Mike Mitka
Journal: JAMA (2002)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
MAGNESIUM SULPHATE SUCCESSFUL IN TWO CASES OF TETANUS.
Authors: HORACE GREELEY
Journal: JAMA (1907)

<h3>Case 1.</h3> —History.—R., a healthy boy, aged 2 years, residing with his parents on Court street, Brooklyn, stepped on an old garden rake and lacerated the web between the great and the adjoining toe of the left foot. Healing progressed under home treatment and the wound was completely closed by the tenth day, when the child was seized, in the morning, by a severe muscular spasm involving. I deduced from hearsay evidence, the muscles of the throat, face, neck and even extending down the trunk and legs. I was sent for, but, being unable to attend at once deputized a friend, who, not being told about the injury, surmised that gastrointestinal troubles were responsible and administered a dose of calomel. In the afternoon of July 16, 1907, when I called, I was informed that the mother had taken the patient out for an airing, as the severe spasms seemed to
New Panel Tackles Clinical Research Funding Cuts
Authors: Charles Marwick
Journal: JAMA (1995)

AS COST-CONSCIOUS managed care organizations become the predominant force in the US health care system, the future of clinical research is in jeopardy. The academic medical centers that, since the 1960s, have provided the facilities for such research are coming under increased pressure to reduce costs. Clinical research, usually more expensive than patient care, is on the firing line. Deeply concerned about this situation, Harold Varmus, MD, director of the National Institutes of Health (NIH), convened an advisory panel of 14 experts to review the problems facing clinical research in the current cost-cutting environment and make recommendations for dealing with them. Chaired by David Nathan, MD, professor of pediatrics, Harvard Medical School, Boston, Mass, the panel met on the NIH campus in Bethesda, Md, last month. As might be expected from an NIH-appointed group, the benefits of clinical research were taken as given. Members agreed with, or at least voiced
Processes in Pathology: An Introduction for Students of Medicine
Authors: Cyril Abrahams
Journal: JAMA (1980)

<i>Processes in Pathology</i>is an excellent text for the student of medicine. The book is just over 400 pages in length and is packed with information that is both basic and advanced in the field of the pathological processes responsible for disease. Eminently readable, clear, and explicit but not dogmatic in areas of controversy, it presents current theories and extensive useful information that make this a book that is of value not only to those entering medicine but to all students of medicine at all levels. It would serve, in addition, as a useful adjunct to the medical student about to take the National Boards Part II, for those taking Specialty Boards, and for practitioners who want to keep abreast of modern developments in the disease process of man. There are five chapters: inflammation, the immune response, the circulation, neoplasia, and the genetic basis of disease. Each chapter is subdivided
Trends in Medical Education
Authors: J. M. Hayman
Journal: New England Journal of Medicine (1962)

THE invitation from the Massachusetts Medical Society to deliver the Annual Discourse for 1962 is an honor that I prize and a task worthy of a great orator. But the choice of this year's speaker from one of the yet small number of medical deans in the Commonwealth shows a prime interest of the Society in medical education. From this platform, Dr. Sosman1 observed six years ago that the subjects presented annually over the last hundred and fifty years covered a wide field of practical, theoretical and philosophical content, but that problems of medical education were foremost. This is as . . .
UNMASKING THE BLINDNESS OF RENAL DENERVATION PROCEDURAL EFFICACY: DOES ELECTRICAL STIMULATION ON RENAL ARTERIAL AUTONOMIC NERVES REALLY WORK?
Authors: Konstantinos P. Tsioufis, Dimitris Tsiachris, Kyriakos Dimitriadis, Athanasios Kordalis, Konstantinos Manakos, Ioannis Kallikazaros, Dimitris Tousoulis, Christodoulos I. Stefanadis
Journal: Journal of the American College of Cardiology (2014)
Ovarian cancer should be treated by specialist teams
Authors: J. Wise
Journal: BMJ (1999)

Women with ovarian cancer should be seen by expert teams based in cancer centres, and if surgery is needed it should by carried out by specialist gynaecological oncologists, according to guidance issued this week by the NHS Executive.

The guidelines, which will be sent to all commissioners of cancer services in England and Wales, state that dedicated diagnostic and assessment services should be established in cancer units, to which all women with suspected gynaecological cancers should …