tbuckley/cabot-search huggingface dataset:
The periodic acid‐schiff reaction and prognosis in children with acute lymphoblastic leukemia
Authors: R. Beverly Raney, Robert S. Festa, Maria T. G. Waldman, David Manson, Hie‐Won L. Hann
Journal: American Journal of Hematology (1979)

Abstract We evaluated the intensity of the periodic acid‐Schiff (PAS) stain reaction by examining 200 lymphoblasts from the initial marrow aspirate specimen of 38 children with acute lymphoblastic leukemia (ALL). The patients were separated into low, intermediate, and high groups according to mean PAS score. The groups were then compared in terms of age, sex, initial hematologic values, T‐ and B‐lymphocyte markers, percentage of patients in remission six months after diagnosis, and percentage surviving. Significant differences were found between the low group and the other two groups with respect to sex, height of initial white blood cell (WBC) count, outlook for continued remission at six months, and overall survival (P &lt; 0.05). The low‐score patients were predominantly males, whereas the other PAS‐score groups contained approximately equal numbers of males and females. The low‐score patients had a higher median initial WBC than the others, but all three groups had a similar proportion of patients with initial WBC under 20,000/cu mm. Low‐score patients were less likely to be in remission six months from diagnosis, and they had shorter survival than the intermediate‐ and high‐score patients (P &lt; 0.05). The results suggest that children with ALL whose lymphoblasts stain weakly with PAS have a worse prognosis than those with intermediate or high PAS reactivity. PAS reactivity may vary independently of the WBC at diagnosis in children with ALL, because children with a low PAS score have a poor outlook even with initial WBC under 20,000/cu mm.
Dr. Beale's Views on Pus-Cells
Authors: J. H. Bennett
Journal: BMJ (1874)

Tu.efl well-k v-n c.-.,;rpuscl.es founid in pus I, w,ith most pathologists, call pus-cells.TO thiis Dr. Beale objects.I-le says they are not cells.He admits that they are like young mucous and epithelial cells to look at; that they exhibit sim-
Abstract C18: Matrix metalloproteinase-1 (MMP-1) facilitates intravasation and vascular dissemination of human carcinoma cells by regulating the microarchitecture and permeability of intratumoral vasculature
Authors: Anna Juncker-Jensen, Berta Casar, Ivo Rimann, Ewa Zajac, Tatyana A. Kupriyanova, Elena I. Deryugina, James P. Quigley
Journal: Cancer Research (2013)

Abstract Patients with squamous cell carcinomas (SCCs) often present with advanced stage disease and face one of the lowest 5-year post-therapeutic survival rates. Among 25 signature genes, Mmp1 has been found to be third best SCC tumor predictor, suggesting a critical role of MMP-1 in SCC progression. Functional role of MMP-1 in SCCs was analyzed in this study by employing a highly-disseminating variant of human epidermoid HEp-3 carcinoma, HEp3-hi/diss. The dissemination capacity of HEp3-hi/diss cells in chick embryo spontaneous metastasis models positively correlated with their high levels of MMP-1 expression. MMP-1-deficiency induced by RNA interference resulted in 70-95% inhibition of HEp3-hi/diss intravasation, concomitant with collapse of the intravasation-sustaining microarchitecture of intratumoral vasculature. Furthermore, we have demonstrated the mechanism whereby HEp3-hi/diss-produced MMP-1 contributes to tumor cell intravasation by proteolytically inducing vascular endothelial permeability and increasing rates of carcinoma cells crossing over vascular barriers during the intravasation step of the metastatic cascade. Citation Format: Anna Juncker-Jensen, Berta Casar, Ivo Rimann, Ewa Zajac, Tatyana A. Kupriyanova, Elena I. Deryugina, James P. Quigley. Matrix metalloproteinase-1 (MMP-1) facilitates intravasation and vascular dissemination of human carcinoma cells by regulating the microarchitecture and permeability of intratumoral vasculature. [abstract]. In: Proceedings of the AACR Special Conference on Tumor Invasion and Metastasis; Jan 20-23, 2013; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2013;73(3 Suppl):Abstract nr C18.
Thymoma-associated Graft-versus-Host Disease-like Erythroderma
Authors: Tomoyuki Nakagiri, Meinoshin Okumura, Masayoshi Inoue, Masato Minami, Eiji Kiyohara, Noriko Umegaki, Toshiaki Nakamura, Yasuhiko Tomita, Ichirou Katayama, Katsuyuki Aozasa
Journal: Journal of Thoracic Oncology (2007)
Angiographic determinants of infarct size after successful percutaneous intervention for acute ST-T elevation myocardial infarction: the impact of distal embolization
Authors: Jose P. Henriques, Felix Zijlstra, Jan Paul Ottervanger, Menko-Jan de Boer, Jan-Henk E. Dambrink, Arnoud W. van 't Hof, Jan C. Hoorntje, Harry Suryapranata
Journal: Journal of the American College of Cardiology (2002)
Genetic deletion of the angiotensin-(1–7) receptor Mas leads to glomerular hyperfiltration and microalbuminuria
Authors: Sérgio V B Pinheiro, Anderson J Ferreira, Gregory T Kitten, Kátia D da Silveira, Deivid A da Silva, Sérgio H S Santos, Elisandra Gava, Carlos H Castro, Júnio A Magalhães, Renata K da Mota, Giancarla A Botelho-Santos, Michael Bader, Natalia Alenina, Robson A S Santos, Ana Cristina Simoes E Silva
Journal: Kidney International (2009)
The Persistently Absent Bowel Loop
Authors: MELISSA J. LEE, LIONEL S. ZUCKIER, BENJAMIN ZALTA, EUGENE FINE
Journal: Clinical Nuclear Medicine (2001)

LEE, MELISSA J. M.D.†; ZUCKIER, LIONEL S. M.D.*†; ZALTA, BENJAMIN M.D.†; FINE, EUGENE M.D.* Author Information
HS1 Functions as an Essential Actin-Regulatory Adaptor Protein at the Immune Synapse
Authors: Timothy S. Gomez, Sean D. McCarney, Esteban Carrizosa, Christine M. Labno, Erin O. Comiskey, Jeffrey C. Nolz, Peimin Zhu, Bruce D. Freedman, Marcus R. Clark, David J. Rawlings, Daniel D. Billadeau, Janis K. Burkhardt
Journal: Immunity (2006)
Treatment with oral clotrimazole blocks Ca(2+)-activated K+ transport and reverses erythrocyte dehydration in transgenic SAD mice. A model for therapy of sickle cell disease.
Authors: L De Franceschi, N Saadane, M Trudel, S L Alper, C Brugnara, Y Beuzard
Journal: Journal of Clinical Investigation (1994)

Prevention of red cell K+ and water loss is a therapeutic strategy for sickle cell disease. We have investigated in vitro and in vivo the effects of clotrimazole (CLT) and miconazole (MIC) on transgenic mice red cells expressing hemoglobin SAD. CLT blocked the Gardos channel (ID50 75 +/- 22 nM; n = 3) and the A23187-induced dehydration of Hbbs/Hbbthal SAD 1 mouse erythrocytes in vitro. Oral treatment with CLT (160 mg/kg per d) and MIC (100 mg/kg per d) inhibited the Gardos channel in both SAD 1 and control (Hbbs/Hbbthal) mice. In the SAD 1 mice only, cell K+ content increased, and mean corpuscular hemoglobin concentration and cell density decreased. After 7 d of treatment, the hematocrit of SAD 1, CLT-treated animals also increased. All changes were fully reversible. Long-term treatments of SAD 1 mice with oral CLT (80 mg/kg per d for 28 d) lead to sustained increases in cell K+ content and hematocrit and sustained decreases in mean corpuscular hemoglobin concentration and cell density, with no changes in animals treated with vehicle alone. Thus, CLT and MIC can reverse dehydration and K+ loss of SAD 1 mouse erythrocytes in vitro and in vivo, further supporting the potential utility of these drugs in the treatment of sickle cell anemia.
Effectiveness of vaccine against pandemic influenza A/H1N1 among people with underlying chronic diseases: cohort study, Denmark, 2009-10
Authors: H.-D. Emborg, T. G. Krause, A. Hviid, J. Simonsen, K. Molbak
Journal: BMJ (2011)

<b>Objective</b> To determine the effectiveness of an adjuvanted monovalent vaccine against pandemic influenza A/H1N1 among people with underlying chronic diseases. <b>Design</b> Historical cohort study. <b>Setting</b> Mandatory national reporting systems, 2 November 2009 to 31 January 2010, Denmark. <b>Participants</b> 388 069 people under 65 years of age with a diagnosis in the past five years of at least one underlying disease expected to increase the risk of severe illness after influenza. <b>Main outcome measures</b> Laboratory confirmed H1N1 infection and influenza related hospital admission with laboratory confirmed H1N1 infection. Estimates of vaccine effectiveness were adjusted for age and underlying disease. <b>Results</b> The effectiveness of pandemic vaccine against confirmed H1N1 infection 14 days after one dose of vaccine was 49% (95% confidence interval 10% to 71%). The effectiveness of vaccine against admission to hospital for confirmed H1N1 infection was 44% (−19% to 73%). <b>Conclusions</b> The adjuvanted monovalent vaccine against pandemic influenza A/H1N1 was offered late in the 2009-10 influenza season. Among chronically ill people, this vaccine offered protection against laboratory confirmed H1N1 infection but only offered non-significant protection against influenza related hospital admissions confirmed as H1N1 infection. This finding is of public health relevance because the population of chronically ill people is a major target group for pandemic vaccinations and because of the delayed availability of pandemic vaccines in a forthcoming pandemic.
Characterization of premature liver polyploidy in DNA repair (Ercc1)-deficient mice
Authors: M Chipchase
Journal: Hepatology (2003)

ERCC1-XPF is the endonuclease that cuts 5' of the damage in nucleotide excision repair (NER). Unlike other NER proteins, ERCC1-XPF is also involved in recombination and the repair of DNA interstrand cross-links. Unique among the NER gene knockouts, Ercc1 null mice are severely runted with high levels of hepatocyte polyploidy. To understand the link between DNA repair deficiency and polyploidy we have compared the premature polyploidy in Ercc1 null liver with the normal development of polyploidy in aging control mice. Polyploidy was accelerated dramatically in Ercc1 null hepatocytes, such that ploidy levels were equivalent in 3-week-old Ercc1 null and 1- to 2-year-old wild-type mouse liver. Levels of the cyclin-dependent kinase inhibitor, p21, were increased in the nuclei of Ercc1 null hepatocytes, and this increase was concentrated in, but not confined to, the polyploid hepatocytes. Much lower levels of p21 messenger RNA (mRNA) were found in old wild-type liver with equivalent levels of ploidy. We suggest that the more rapid accumulation of DNA damage in Ercc1 null liver leads to an increase in p21 levels, but that there is not a simple direct link between p21 levels and premature polyploidy. The failure to observe any link between p21 levels and polyploidy in aged wild-type liver may be attributable to the much lower levels of accumulated DNA damage, the much greater timescale involved, or the existence of a p21-independent mechanism for polyploidy. In conclusion, the premature polyploidy in Ercc1-deficient liver differs from the normal aging-related process.
A New Design for Randomized Clinical Trials
Authors: Marvin Zelen
Journal: New England Journal of Medicine (1979)

Abstract This paper proposes a new method for planning randomized clinical trials. This method is especially suited to comparison of a best standard or control treatment with an experimental treatment. Patients are allocated into two groups by a random or chance mechanism. Patients in the first group receive standard treatment; those in the second group are asked if they will accept the experimental therapy; if they decline, they receive the best standard treatment. In the analyses of results, all those in the second group, regardless of treatment, are compared with those in the first group. Any loss of statistical efficiency can be overcome by increased numbers. This experimental plan is indeed a randomized clinical trial and has the advantage that, before providing consent, a patient will know whether an experimental treatment is to be used. (N Engl J Med 300:1242–1245, 1979)
Subacute Thrombotic Occlusion and Spontaneous Recanalization of the Right Coronary Artery After Percutaneous Coronary Intervention for ST-Elevation Myocardial Infarction Visualized by Coronary Angiography and Cardiac Magnetic Resonance Imaging
Authors: Rainer Wessely, Rene M. Botnar, Marc Vorpahl, Markus Schwaiger, Albert Schömig, Tareq Ibrahim
Journal: Circulation (2007)
Deadly New Virus?
Authors: Joan Stephenson
Journal: JAMA (2008)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Ten Recommendations for Advancing Patient-Centered Outcomes Measurement for Older Persons
Authors: Colleen A. McHorney
Journal: Annals of Internal Medicine (2003)

The past 50 years have seen great progress in the measurement of patient-based outcomes for older populations. Most of the measures now used were created under the umbrella of a set of assumptions and procedures known as classical test theory. A recent alternative for health status assessment is item response theory. Item response theory is superior to classical test theory because it can eliminate test dependency and achieve more precise measurement through computerized adaptive testing. Computerized adaptive testing reduces test administration times and allows varied and precise estimates of ability. Several key challenges must be met before computerized adaptive testing becomes a productive reality. I discuss these challenges for the health assessment of older persons in the form of 10 Ds: things we need to deliberate, debate, decide, and do.
Companies’ Use of Web to Recruit Patients for Studies Brings Opportunities, Risks
Authors: Bridget M. Kuehn
Journal: JAMA (2008)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Molecular Engineering of a Two-Step Transcription Amplification (TSTA) System for Transgene Delivery in Prostate Cancer
Authors: Liqun Zhang, Jason Yeates Adams, Erika Billick, Romyla Ilagan, Meera Iyer, Kim Le, Andrea Smallwood, Sanjiv S Gambhir, Michael Carey, Lily Wu
Journal: Molecular Therapy (2002)

Gene therapy is founded on the concept that tissue-specific promoters can express heterologous genes for molecular imaging or therapeutic applications. The engineering of cell-specific enhancers to improve potency and the development of two-step transcriptional activation (TSTA) approaches have significantly improved the efficacy of transgene expression. Here we combine these technologies to create a robust, titratable, androgen-responsive system targeted to prostate cancer cells. Our "chimeric" TSTA system uses a duplicated variant of the prostate-specific antigen (PSA) gene enhancer to express GAL4 derivatives fused to one, two, or four VP16 activation domains. We targeted the resulting activators to cells with reporter templates bearing one, two, or five GAL4 binding sites upstream of firefly luciferase. We monitored activity via firefly luciferase assays in transfected cell extracts and in live nude mice using a cooled charge-coupled device (CCD) imaging system. In this system, we found that firefly luciferase expression in prostate cancer cells can be varied over an 800-fold range. We also found that a single plasmid bearing the optimized enhancer, GAL4–VP16 derivative, and reporter expressed firefly luciferase at 20-fold higher levels than the cytomegalovirus enhancer. We discuss the implications of this strategy and its application to molecular imaging and therapy.
Thrombospondin-1, Vascular Endothelial Growth Factor Expression and Microvessel Density in Renal Cell Carcinoma and Their Relationship with Multifocality
Authors: Sümer Baltacı, Diclehan Orhan, Çağatay Göğüş, Ercan Filiz, Özden Tulunay, Orhan Göğüş
Journal: European Urology (2003)
Structural Evolution of Otx Genes in Craniates
Authors: A. Germot, G. Lecointre, J.-L. Plouhinec, C. Le Mentec, F. Girardot, S. Mazan
Journal: Molecular Biology and Evolution (2001)

Using a degenerate PCR approach, we performed an exhaustive search of Otx genes in the reedfish Erpetoichthys calabaricus, the dogfish Scyliorhinus canicula, and the hagfish Myxine glutinosa. Three novel Otx genes were identified in each of these species, and their deduced protein sequences were determined over a large C-terminal fragment located immediately downstream of the homeodomain. Like their lamprey and osteichthyan counterparts, these nine genes display a tandem duplication of a 20–25-residue C-terminal domain, which appears to be a hallmark of all craniate Otx genes identified thus far, including the highly divergent Crx gene. Phylogenetic analyses show that, together with their osteichthyan counterparts, the dogfish and reedfish genes can be classified into three gnathostome orthology classes. Two of the three genes identified in each of these species belong to the Otx1 and Otx2 orthology classes previously characterized in osteichthyans. The third one unambiguously clusters with the Otx5/Otx5b genes recently characterized in Xenopus laevis, thus defining a novel orthology class. Our results also strongly suggest that the highly divergent Crx genes identified in humans, rodents, and oxen are the mammalian representatives of this third class. The hagfish genes display no clear relationships to the three gnathostome orthology classes, but one of them appears to be closely related to the LjOtxA gene, previously identified in Lampetra japonica. Taken together, these data support the hypothesis that the Otx multigene families characterized in craniates all derive from duplications of a single ancestral gene which occurred after the splitting of cephalochordates but prior to the gnathostome radiation. Using site-by-site sequence comparisons of the gnathostome Otx proteins, we also identified structural constraints selectively acting on each of the three gnathostome orthology classes. This suggests that specialized functions for each of these orthology classes were fixed in the gnathostome lineage prior to the splitting between osteichthyans and chondrichthyans.
Evidence Supporting Cholesterol-Lowering Therapy for Postmenopausal Women With Heart Disease
Authors: Mark R. Goldstein
Journal: JAMA (1997)

<h3>To the Editor.</h3> —Dr Schrott and colleagues<sup>1</sup>suggest that women with established coronary heart disease have been undertreated for elevated low-density lipoprotein cholesterol (LDLC) levels based on screening data from the Heart and Estrogen/ Progestin Replacement Study (HERS). However, evidencebased medicine suggests the women were adequately treated. At screening, nearly half of the participants of the trial were taking cholesterol-lowering medication. The suggestion that women were undertreated was based on the failure of a majority of the HERS cohort to have achieved LDL-C goals set by the National Cholesterol Education Program (NCEP) adult treatment panel in 1988<sup>2</sup>and 1993.<sup>3</sup>Those goals were derived from trials involving men and extrapolated to women. The screening for HERS ended in September 1994, before evidence-based medicine suggested that women might benefit from cholesterol lowering. The Scandinavian Simvastatin Survival Study (4S)<sup>4</sup>and the Cholesterol and Recurrent Events (CARE) trial<sup>5</sup>were
Myocardial Infarction in Two Sisters Less Than 20 Years Old
Authors: Isidor C. Brill
Journal: JAMA (1971)

Myocardial infarction occurred in two sisters, ages 18 and 19 years, respectively. The younger (case 1) died following an attempt to revascularize the myocardium by the Vineberg procedure. The lesions in this case differed from the arteriosclerotic changes usually present in occlusive coronary artery disease in that an advanced degree of intimal fibrous proliferation without associated lipid or calcium deposits was the sole pathological process observed.
The Estrogen Elixir: A History of Hormone Replacement Therapy in America
Authors: K. Eddie Gabry
Journal: JAMA (2008)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Tool use induces complex and flexible plasticity of human body representations
Authors: Matthew R. Longo, Andrea Serino
Journal: Behavioral and Brain Sciences (2012)

Abstract Plasticity of body representation fundamentally underpins human tool use. Recent studies have demonstrated remarkably complex plasticity of body representation in humans, showing that such plasticity (1) occurs flexibly across multiple time scales and (2) involves multiple body representations responding differently to tool use. Such findings reveal remarkable sophistication of body plasticity in humans, suggesting that Vaesen may overestimate the similarity of such mechanisms in humans and non-human primates.