tbuckley/cabot-search huggingface dataset:
A MODIFICATION OF THE YOUNG PROSTATIC TRACTOR
Authors: HARVEY A. MOORE
Journal: JAMA (1910)

I have used Dr. Hugh H. Young's prostatic tractor successfully in a number of perineal prostatectomies, yet I have found it very difficult of introduction in a few cases and have therefore devised the instrument here illustrated, which is straight and has the advantage of being easily introduced through the perineal opening in the urethra. By turning the thumb-screw the blades are opened at right angles to the shaft, giving the shape and the tractile advantages of the original instrument.
The Relative Safety of Ephedra Compared with Other Herbal Products
Authors: Annette Dickinson
Journal: Annals of Internal Medicine (2003)

Letters2 September 2003The Relative Safety of Ephedra Compared with Other Herbal ProductsAnnette Dickinson, PhDAnnette Dickinson, PhDFrom Council for Responsible Nutrition; Washington, DC 20036.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-139-5_Part_1-200309020-00019 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:As president of the Council for Responsible Nutrition, a trade association representing the dietary supplement industry, I am familiar with market data regarding industry sales and the fraction of those sales accounted for by herbal products generally and by ephedra products specifically. The article by Bent and colleagues (1) on the relative safety of ephedra purported to show that ephedra products account for less than 1% of the market for herbal supplements (specifically, 0.82%), yet are associated with a high percentage of adverse events reported to poison control centers. Unfortunately, the authors relied on sales data that ...References1. Bent S, Tiedt TN, Odden MC, Shlipak MG. The relative safety of ephedra compared with other herbal products. Ann Intern Med. 2003;138:468-71. [PMID: 12639079] LinkGoogle Scholar2. NBJ's Annual Industry Overview VIII. Nutrition Business Journal. 2003;VIII:1-9. Google Scholar Author, Article, and Disclosure InformationAuthors: Annette Dickinson, PhDAffiliations: From Council for Responsible Nutrition; Washington, DC 20036. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoThe Relative Safety of Ephedra Compared with Other Herbal Products Stephen Bent , Thomas N. Tiedt , Michelle C. Odden , and Michael G. Shlipak The Relative Safety of Ephedra Compared with Other Herbal Products Stephen Bent , Thomas N. Tiedt , and Michael G. Shlipak The Relative Safety of Ephedra Compared with Other Herbal Products Richard L. Kingston and Stephen W. Borron The Relative Safety of Ephedra Compared with Other Herbal Products Julian M. Whitaker The Relative Safety of Ephedra Compared with Other Herbal Products Julian M. Whitaker The Relative Safety of Ephedra Compared with Other Herbal Products Richard L. Kingston and Stephen W. Borron The Relative Safety of Ephedra Compared with Other Herbal Products Stephen Bent , Thomas N. Tiedt , and Michael G. Shlipak Metrics Cited bySafety Assurances for Dietary SupplementsLiteratureWatch 2 September 2003Volume 139, Issue 5_Part_1Page: 385KeywordsAdverse eventsFoodNutritionRelative riskSafety ePublished: 2 September 2003 Issue Published: 2 September 2003 Copyright & PermissionsCopyright © 2003 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Effect on hospital attendance rates of giving patients a copy of their referral letter: randomised controlled trial
Authors: W. Hamilton, A. Round, D. Sharp
Journal: BMJ (1999)

To investigate whether sending patients a copy of their referral letter can reduce non-attendance at outpatient departments.Blinded randomised controlled trial.13 general practices in Exeter, Devon.2078 new consultant referrals from 26 doctors.Non-attendance at outpatient departments.The doctors excluded 117 (5.6%) referrals, and 100 (4.8%) received no appointment. Attendance data were available for 1857 of the 1861 patients sent an appointment (99.8%). The receipt of a copy letter had no effect on the non-attendance rate: copy 50/912 (5.5%) versus control 50/945 (5.3%).Copy letters are ineffective in reducing non-attendance at outpatient departments.
Donald Forbes Mungall
Authors: Ian Mungall
Journal: BMJ (2005)

​FormerFormer general practitioner York (b Carlisle 1916; q Edinburgh 1939), died from generalised cerebrovascular disease on 10 September 2005.




Figure 1




During the second world war Don served for four years in the Royal Air Force Volunteer Reserve, mostly in the Western desert. On demobilisation he joined a long established practice in York, where he combined an enthusiasm for new developments with traditional patient centred care. He was medical officer to Bootham School, St John's Teacher Training College, and York Water-works, of which he was also a director. His year as president of the York Medical Society was marked by his restoration of the society's historic rooms. He leaves a wife, Bishie; three children; and four grandchildren.
Battered Children of All Ages
Authors: Samuel Vaisrub
Journal: JAMA (1979)

Few encounters are more disturbing to the physician than an encounter with a battered child or a tortured political prisoner. Distinct from each other, yet closely related, child abuse and prisoner torture may have similar physical and psychological effects, but their motivations, causes, and management often differ.  Political prisoners are tortured to obtain information, extract a confession, or simply to amuse the jailers. Sometimes, as in enforced confinement to mental institutions, the aim is to undermine the inmate's self-confidence and to discredit him in the eyes of society. Our sensibilities, albeit somewhat dulled by the revelations of mass torture in concentration camps, can be shaken still by disclosures of recently perpetrated tortures in prisons.  One such disclosure published in a recent issue of the Canadian Medical Association Journal records a detailed study on 11 torture victims applying for refugee status, whose harrowing reminiscences were corroborated by scars and biopsy specimens
THE CREDULITY OF THE PEOPLE AS IT PERTAINS TO MEDICINE AND RELIGION.
Authors: T. B. GREENLEY
Journal: JAMA (1900)

It would seem, from our every-day reading and observation, that the faith or credulity of the people is greatly on the increase. And this faith in the virtues of medicine and so-called doctors, is only equalled, or excelled, by religious instincts. If a new doctrine, either in medicine or religion, is promulgated, no difference how absurd it may be in the estimation of persons of common sense, there will soon be many believers or followers to embrace it. By way of illustration we will allude to a few instances of this fallacious credulity, first as it relates to medicine. We see every day in the secular newspapers advertisements of wonderful curative remedies which have relieved patients after the treatment of the best doctors has failed to cure, and such published statements are calculated to excite the minds of the credulous to believe the statements, and if unwell, to try the
An Evaluation of an Alternative Dosing Regimen with Tadalafil, 3 Times/Week, for Men with Erectile Dysfunction: SURE Study in 14 European Countries
Authors: Vincenzo Mirone, Pierre Costa, Jan-Erik Damber, Simon Holmes, Ignacio Moncada, Hermann Van Ahlen, Eric Wespes, William H. Cordell, Melanie Chan, Danilo Lembo, Lucio Varanese
Journal: European Urology (2005)
Population screening for congenital hypothyroidism.
Authors: J A Hulse, D B Grant, B E Clayton, P Lilly, D Jackson, A Spracklan, R W Edwards, D Nurse
Journal: BMJ (1980)

A pilot screening programme for congenital hypothyroidism covering most of North London, Essex, Bedfordshire, and Hertfordshire entailed carrying out an assay of thyroid-stimulating hormone on single Guthrie dried blood spots. During one year 87 444 babies were screened and 26 cases of primary congenital hypothyroidism detected, giving an incidence of 1:3363. Only two cases (7.7%) had already been diagnosed on clinical grounds before the results of screening became available. In two other babies the diagnosis was delayed. The programme thus resulted in the early treatment of 22 babies, eight of whom already had pronounced features of hypothyroidism that had not been detected on routine clinical examinations. Although definitive evidence will not be available for some years, the results suggest that the prognosis for most of these babies is likely to be improved by early diagnosis; thus the introduction of national screening should be delayed no longer.
Overlap connective tissue disease, pulmonary fibrosis, and extensive subcutaneous calcification
Authors: A T Y Chan
Journal: Annals of the Rheumatic Diseases (2003)

<h3>Abstract</h3> Recently, a novel variant p.Y314S in <i>UQCRC1</i> has been implicated as pathogenic in Parkinson's disease (PD). In the current study, we aimed to examine the association of <i>UQCRC1</i> with PD in large cohorts of European origin. We examined common and rare genetic variation in <i>UQCRC1</i> using genome-wide association study data from the International Parkinson Disease Genomics Consortium (IPDGC), including 14,671 cases and 17,667 controls, and whole-genome sequencing data from the Accelerating Medicines Partnership - Parkinson's disease initiative (AMP-PD), including 1,647 PD patients and 1,050 controls. No common variants were consistently associated with PD, and a variety of burden analyses did not reveal an association between rare variants in <i>UQCRC1</i> and PD. Therefore, our results do not support a major role for <i>UQCRC1</i> in PD in the European population, and additional studies in other populations are warranted.
Persistent Baltic cough
Authors: E. Moran, A. McGown, C. Conlon
Journal: BMJ (2010)

A 22 year old female Lithuanian student studying in the United Kingdom presented to her university's health centre on several occasions over a three month period starting in May 2008. She had moved to the UK in 2004 and had received the BCG vaccination some years previously. She described cough productive of sputum and night sweats, and she was given three courses of antibiotics that had little effect. By August 2008, the patient had lost 4 kg in weight and was referred to her local hospital. On examination the only findings were a temperature of 37.6°C and a mild expiratory wheeze. Chest radiography showed a small patch of left upper lobe consolidation. Sputum was collected for examination, and she was treated empirically with doxycyline and co-amoxiclav. She was HIV negative. The patient was seen in the chest clinic the following week and informed that sputum microscopy had shown acid fast bacilli. She was started on rifampicin, isoniazid, pyrazinamide, ethambutol, and pyridoxine. Sputum culture confirmed Mycobacterium tuberculosis shortly afterwards. Review two weeks later suggested that the patient was improving. One month after starting therapy for tuberculosis, the clinic was contacted by the National Mycobacterium Reference Laboratory and informed that the patient's isolate was resistant to all tested first line drugs. All four anti-tuberculous agents were stopped pending further sensitivity data. Three weeks later, the National Mycobacterium Reference Laboratory issued a further report confirming resistance to all fluoroquinolones and kanamycin sulphate.
Visualization of Thyroglossal Duct Cyst in Differentiated Thyroid Cancer Patient
Authors: Dong Li, Zhaowei Meng, Guizhi Zhang, Tielian Yu, Jian Tan, Feng Dong
Journal: Clinical Nuclear Medicine (2010)

Iodine-131 (I-131) treatment and subsequent whole body iodine-131 scans (WBSs) are important in the management of differentiated thyroid carcinoma (DTC). Nevertheless, false positive benign lesions in WBS should be interpreted with reliable anatomic imaging methodologies to differentiate from true metastases. We report a DTC case with a concurrent thyroglossal duct cyst (TDC), which is relatively uncommon compared with an accompanying lingual thyroid. After thyroid remnant ablation, subsequent posttherapeutic WBS showed a stable I-131 avid lesion in the neck despite cumulative dosage of 346 mCi I-131. Low level of thyroglobulin indicated that the lesion should be from thyroid origin, yet only a small amount of thyroid remnant should be contained. Magnetic resonance imaging and computed tomography were performed and revealed a dumbbell-shaped TDC. Part of the lesion was behind the hyoid bone, part of it protruded to the anterior surface of the thyroid cartilage, and the isthmus penetrated through the thyrohyoid membrane. Although the shape of this TDC reflects the route of the thyroglossal duct in embryological perspective, its coincidence with DTC is rarely documented. Our case also proved that the possibility of concurrent TDC should be considered as the cause of residual thyroglobulin for an I-131 avid lesion in the midline anterior cervical area, which could show great resistance to I-131 therapy.
Abstract 1717: Prognostic impact of cancer stem cell-related markers in non-small cell lung cancer patients treated with induction chemoradiotherapy
Authors: Kazuhiko Shien, Shinichi Toyooka, Kouichi Ichimura, Junichi Soh, Masashi Furukawa, Yuho Maki, Takayuki Muraoka, Norimitsu Tanaka, Tsuyoshi Ueno, Hiroaki Asano, Kazunori Tsukuda, Hiromasa Yamamoto, Masaomi Yamane, Takahiro Oto, Katsuyuki Kiura, Shinichiro Miyoshi
Journal: Cancer Research (2012)

Abstract Background: Several cancer stem cell (CSC) related markers have been confirmed to be expressed in non-small cell lung cancer (NSCLC). The aim of this study was to clarify the prognostic role of CSC related markers expression in locally advanced NSCLC with induction chemoradiotherap (CRT).Methods: Fifty patients with clinically N2 or N3 NSCLC underwent induction CRT with cisplatin and docetaxel concurrently with thoracic radiation followed by surgery. Expressions of CSC related markers (CD133, ABCG2, ALDH1, and Bmi-1) were examined by immunohistochemical stain from surgical resected specimen. The prognostic factors were investigated by multivariate analysis using Cox proportional hazard model.Results: Among 50 patients, 20 patients had no pathologically residual tumor cell in the surgical resected specimen, and CSC related markers expressions were evaluated in other 30 patients. With a median follow-up duration of 71 months, the 5-year overall survival rate in the patients of CD133 or ALDH1 -positive was significantly worse than that in the patients of CD133 and ALDH1 -negative (90.0% vs. 44.9%, respectively, P = 0.042). In multivariate analysis, CD133 and ALDH1 negativity (Hazard ratio [HR] 0.16, 95% confidential interval [CI]: 0.0086-0.98, P = 0.047) and c-N2-3 single node metastasis (not multi node metastasis) (HR 0.19, 95% CI: 0.028-0.91, P = 0.03) were significant independent prognostic factors for the prolongation of survival.Discussion: The expressions of CSC related markers after CRT are significantly related to poor prognosis in NSCLC. The development of therapeutic strategy including adjuvant therapy, is a key for further improvement of prognosis in patients who underwent trimodality therapy. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 103rd Annual Meeting of the American Association for Cancer Research; 2012 Mar 31-Apr 4; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2012;72(8 Suppl):Abstract nr 1717. doi:1538-7445.AM2012-1717
Familial hypercatabolic hypoproteinemia. A disorder of endogenous catabolism of albumin and immunoglobulin.
Authors: T A Waldmann, W D Terry
Journal: Journal of Clinical Investigation (1990)

The metabolism of albumin and IgG was investigated in two siblings, products of a first-cousin marriage, a female aged 34 yr and a male aged 17, who had a marked reduction in their respective serum concentrations of IgG (1.3 and 3.1 mg/ml) and albumin (19 and 21 mg/ml). The metabolism of radioiodinated IgG and albumin was studied in the two patients. The total circulating and body pools of IgG were less than 28% of normal. The IgG synthetic rates were within the normal range. However, the IgG survival was short, with their respective fractional catabolic rates increased fivefold to 31% and 36% of the intravenous pool per day (normal, 6.7 +/- 2%/d). Furthermore, the patients had reduced total body pools, normal synthetic rates, and increased fractional catabolic rates for albumin. There was no proteinuria or abnormality of renal or liver function. In addition, the patients did not have circulating antibodies directed toward IgG, IgA, or albumin. Furthermore, both patients had normal fecal 51Cr-labeled albumin tests, thus excluding excessive gastrointestinal protein loss. We propose that these siblings have a previously unrecognized familial disorder characterized by reduced serum concentrations of IgG and albumin caused by a defect in endogenous catabolism, leading to a short survival of these proteins that is associated in this family with chemical diabetes and a skeletal deformity.
Effects of insulin-like growth factor-I on glucose tolerance, insulin levels, and insulin secretion.
Authors: P D Zenobi, S Graf, H Ursprung, E R Froesch
Journal: Journal of Clinical Investigation (1992)

Insulin-like growth factor-I (IGF-I) and insulin interact with related receptors to lower plasma glucose and to exert mitogenic effects. Recombinant human IGF-I (rhIGF-I) was recently shown to decrease serum levels of insulin and C-peptide in fasted normal subjects without affecting plasma glucose levels. In this study we have investigated in six healthy volunteers the responses of glucose, insulin, and C-peptide levels to intravenous rhIGF-I infusions (7 and 14 micrograms/kg.h) during standard oral glucose tolerance tests (oGTT) and meal tolerance tests (MTT), respectively. Glucose tolerance remained unchanged during the rhIGF-I infusions in the face of lowered insulin and C-peptide levels. The decreased insulin/glucose-ratio presumably is caused by an enhanced tissue sensitivity to insulin. The lowered area under the insulin curve during oGTT and MTT as a result of the administration of rhIGF-I were related to the fasting insulin levels during saline infusion (oGTT: r = 0.825, P less than 0.05; MTT: r = 0.895, P less than 0.02). RhIGF-I, however, did not alter the ratio between C-peptide and insulin, suggesting that the metabolic clearance of endogenous insulin remained unchanged. In conclusion, rhIGF-I increased glucose disposal and directly suppressed insulin secretion. RhIGF-I probably increased insulin sensitivity as a result of decreased insulin levels and suppressed growth hormone secretion. RhIGF-I, therefore, may be therapeutically useful in insulin resistance of type 2 diabetes, obesity, and hyperlipidemia.
The Vectorcardiogram and Electrocardiogram in Persistent Common Atrioventricular Canal
Authors: JONAS BEREGOVICH, SELVYN BLEIFER, EPHRAIM DONOSO, ARTHUR GRISHMAN
Journal: Circulation (1960)

The electrocardiogram and vectorcardiogram are of great aid in differentiating atrial septal defect of the secundum type from the ostium-primum type. In the latter condition there is left axis deviation in the scalar electrocardiogram and superior orientation of the QRS vector in the sagittal and frontal planes. There are relatively few congenital lesions that lead to the same degree of axis deviation and superior orientation of the QRS vector.
Forensic Medicine: Clinical and Pathological Aspects
Authors: F. T. Zugibe
Journal: JAMA (2003)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Take as Directed?
Authors: Sam Lerman
Journal: JAMA (1974)

<h3>To the Editor.—</h3> Prescriptions labeled "as directed" have aroused my concern as well as that of pharmacists Powell, Cali, and Linkewich ("Inadequately Written Prescriptions," 226:999, 1973). Frequently, I write a prescription for a medication and "Sig: With manufacturer's directions." Almost inevitably, if I have occasion to see the label, it reads, "Take as directed." All too many pharmacists disregard the instruction on our prescription blanks to "Label as Such." They will not take the trouble to transcribe the recommended dosage provided by the manufacturer. A dose of vermifuge is dependent on the child's weight. Is it asking too much, if the mother provides the weight of each child, for the pharmacist to provide the dose for each child? Verbal instructions are unreliable; my handwriting is not very legible to patients. Cannot the pharmacist type out the manufacturer's instructions— or better still—give the patient the package insert,<i>underlining the dosage instructions?</i>
Platelet calcium‐dependent proteins: Identification and localization of the calcium‐dependent regulator, calmodulin, in platelets
Authors: Gilbert C. White, Steven N. Levine, Alton N. Steiner
Journal: American Journal of Hematology (1981)

The calcium-dependent regulator protein, calmodulin, is a 17,000 molecular weight polypeptide which binds calcium and has been shown to confer calcium sensitivity on contractile and other proteins. In the present study, we have examined the presence and subcellular distribution of this protein in preparations of human platelets. Calmodulin was quantified using a two-stage phosphodiesterase assay. Whole platelets contained 1.33 +/- 0.06 units calmodulin per 10(6) platelets or 26.5 +/- 3.4 fg calmodulin per platelet. The distribution of calmodulin in the platelet was predominantly soluble with over 80 percent of calmodulin activity in the soluble fraction of the cell. There was no apparent difference in the distribution of calmodulin between soluble and particulate compartments in recalcified platelet homogenates compared to homogenates in EDTA. Indirect immunofluorescent studies with monospecific antisera to dinitrophenylated calmodulin showed intense staining of platelets in a diffuse pattern. The identification of calmodulin in platelets raises the possibility that this protein may participate in calcium-dependent reactions important in platelet aggregation and release.
Possible Role of Endothelin in Endothelial Regulation of Vascular Tone
Authors: T Masaki
Journal: The Annual Review of Pharmacology and Toxicology (1995)

Heme oxygenases (HO) catabolize free heme, that is, iron (Fe) protoporphyrin (IX), into equimolar amounts of Fe2+, carbon monoxide (CO), and biliverdin. The stress-responsive HO-1 isoenzyme affords protection against programmed cell death. The mechanism ...Read More