THE TOXICITY OF BENADRYL: REPORT OF A CASE AND REVIEW OF THE LITERATURE
Authors: Bernard A. Sachs
Journal: Annals of Internal Medicine (1948)

Case Reports1 July 1948THE TOXICITY OF BENADRYL: REPORT OF A CASE AND REVIEW OF THE LITERATUREBERNARD A. SACHSBERNARD A. SACHSSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-29-1-135 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptBenadryl‡ (b-dimethylaminoethyl benzhydryl ether hydrochloride) is an anti-histaminic substance synthesized by Rieveschl and Huber and first reported by Loew, Kaiser and Moore.37 Ever since the first clinical report by Curtis and Owens1 toxic reactions have been mentioned frequently and prominently. A recent instance led us to review the literature and attempt to ascertain the frequency and character of toxic reactions and the relation of reaction to dosage. Toxic reactions have been variously termed side effects, side reactions, side actions, untoward reactions or untoward effects and these terms will be used interchangeably.CASE REPORTThe patient, a 28 year old white...Bibliography1. CURTISOWENS ACBB: B-dimethylaminoethyl benzhydryl ether HCl (benadryl) in treatment of urticaria, Univ. Hosp. Bull., Ann Arbor, 1945, xi, 25; Arch. Dermat. and Syph., 1945, lii, 239. Google Scholar2. MCELINHORTON TWBT: Clinical observations on the use of benadryl: a new antihistaminic substance, Proc. Staff Meet., Mayo Clin., 1945, xx, 417. Google Scholar3. O'LEARYFARBER PAEM: Benadryl in the treatment of urticaria, ibid., 1945, xx, 429. Google Scholar4. WALDBOTT GL: Clinical results with benadryl, Jr. Allergy, 1946, xvii, 142; New anti-histaminic drugs in allergic diseases, Jr. Mich. Med. Soc., 1946, xlv, 1051. CrossrefGoogle Scholar5. LEVIN SJ: B-dimethylaminoethyl benzhydryl ether hydrochloride (benadryl). Its use in allergic diseases, Jr. Allergy, 1946, xvii, 145. CrossrefGoogle Scholar6. KOELSCHEPRICKMANCARRYER GALEHM: The symptomatic treatment of bronchial asthma and hay fever with b-dimethylaminoethyl benzhydryl ether hydrochloride, ibid., 1946, xvii, 151; Proc. Staff Meet., Mayo Clin., 1945, xx, 432. Google Scholar7. EYERMAN CH: Clinical experiences with a new antihistaminic drug, Jr. Allergy, 1946, xvii, 210. CrossrefGoogle Scholar8. JENKINSSCHREIBERSHELDON DEEOJM: Benadryl (b-dimethylaminoethyl benzhydryl ether HCl) in the treatment of hay fever and asthma, Univ. Hosp. Bull., Ann Arbor, 1946, xii, 30. Google Scholar9. MCGAVACKELIASBOYD THHLJ: The influence of dimethylaminoethyl benzhydryl ether HCl (benadryl) upon normal persons and upon those suffering from disturbances of the autonomic nervous system. Preliminary report, Jr. Lab. and Clin. Med., 1946, xxxi, 560. Google Scholar10. BAREFOOTRILEYKUHN SWKABH: B-dimethylaminoethyl benzhydryl ether HCl in the treatment of urticaria and related dermatoses, N. Carolina Med. Jr., 1946, vii, 150. Google Scholar11. BARNETTBARBASGOSS SEFMSB: Benadryl in hay fever, asthma and vasomotor rhinitis, Jr. Mich. Med. Soc., 1946, xlv, 771. Google Scholar12. ZOLOV B: Benadryl—a new antihistamine agent in allergic disease, Jr. Maine Med. Assoc., 1946, xxxvii, 126. Google Scholar13. FRIEDLANDER AS: The use of a histamine antagonist, b-dimethyl-aminoethyl benzhydryl ether HCl in allergic disease, Am. Jr. Med. Sci., 1946, ccxii, 185. CrossrefGoogle Scholar14. ARNOLD HL: Symptomatic control of urticaria and its equivalents by "benadryl," Proc. Clinic, Honolulu, 1945, xi, 123; Benadryl in chronic urticaria, Arch. Dermat. and Syph., 1946, liv, 71. Google Scholar15. LOFSTROMNURNBERGER JEEE: Irradiation sickness: histamine effect treated with benadryl, Am. Jr. Roentgenol., 1946, lvi, 211. Google Scholar16. SCHWARTZLEVIN EL: Benadryl in the symptomatic treatment of allergy, N. Y. State Jr. Med., 1946, xlvi, 1233. Google Scholar17. LOGAN GB: The use of benadryl in treating some of the allergic diseases of childhood, Proc. Staff Meet., Mayo Clin., 1945, xx, 436. Google Scholar18. O'LEARYFARBER PAEM: Evaluation of benadryl in the treatment of urticaria, scleroderma and allied disturbances, ibid., 1946, xxi, 295. Google Scholar19. MCGAVACKELIASBOYD THHLJ: Some pharmacological and clinical experiences with dimethylaminoethyl benzhydryl ether HCl (benadryl), Bull. N. Y. Acad. Med., 1946, xxii, 481. Google Scholar20. NOTIERROTH VAGM: Treatment of hypersensitiveness to cold with benadryl: report of a case, Proc. Staff Meet., Mayo Clin., 1946, xxi, 170. Google Scholar21. TAUB SJ: The use of a new anti-histamine drug (benadryl) in allergic diseases, Quart., Chicago Med. School, 1945, vii, 6. Google Scholar22. HARLEY D: Benadryl in hay fever, Lancet, 1946, ii, 158. CrossrefGoogle Scholar23. MACINNIS HF: Clinical observations on the use of benadryl, a new anti-histamine compound, Canad. Med. Assoc. Jr., 1946, lv, 476. Google Scholar24. FRIEDLANDER S: Experimental and clinical evaluation of synthetic anti-histamine drugs, Am. Jr. Med., 1946, i, 174. CrossrefGoogle Scholar25. KELLY WH: Anti-histamine agents, Jr. S. Carolina Med. Assoc., 1946, xlii, 209. Google Scholar26. TODD LC: Some clinical observations on the use of benadryl for the symptomatic relief of allergic conditions, Ann. Allergy, 1946, iv, 282; N. Carolina Med. Jr., 1946, vii, 308; Urticaria—with observations on the use of the new anti-histamine drug, benadryl, South. Med. and Surg., 1946, cviii, 1. Google Scholar27. FRIEDLANDERFEINBERG SSM: Histamine antagonists: III. The effect of oral and local use of b-dimethylaminoethyl benzhydryl ether hydrochloride on the whealing due to histamine, antigen-antibody reactions, and other whealing mechanisms; therapeutic results in allergic manifestations, Jr. Allergy, 1946, xvii, 129. CrossrefGoogle Scholar28. WILLIAMS HL: Use of benadryl in the syndrome of physical allergy of the head: a preliminary report, Proc. Staff Meet., Mayo Clin., 1945, xx, 434. Google Scholar29. BLANK WH: Some clinical experiences with benadryl, Jr. Med. Assoc. Alabama, 1946, xv, 367. Google Scholar30. BOWEN R: Benadryl, its therapeutic value in allergy, Texas State Jr. Med., 1946, xlii, 188. Google Scholar31. SLATERFRANCIS BJN: Benadryl, a contributing cause of an accident, Jr. Am. Med. Assoc., 1946, cxxxii, 212. CrossrefGoogle Scholar32. RIEVESCHLGRUHZIT GOM: A toxicologic study of histamine antagonist b-dimethylaminoethyl benzhydryl ether HCl (benadryl), Fed. Proc., 1945, iv, 150. Google Scholar33. LOEWMACMILLANKAISER ERRME: Anti-histamine properties of benadryl, b-dimethylaminoethyl benzhydryl ether hydrochloride, Jr. Pharmacol. and Exper. Therap., 1946, lxxxvi, 229. Google Scholar34. CODE CF: A discussion of benadryl as an antihistaminic substance, Proc. Staff Meet., Mayo Clin., 1945, xx, 439. Google Scholar35. FEINBERG SM: Histamine and antihistaminic agents, Jr. Am. Med. Assoc., 1946, cxxxii, 702. Google Scholar36. WELLSMORRISBULLDRAGSTEDT JAHCHBCA: Observations on the nature of the antagonism of histamine by b-dimethylaminoethyl benzhydryl ether hydrochloride (benadryl), Jr. Pharmacol. and Exper. Therap., 1945, lxxxv, 122. Google Scholar37. LOEWKAISERMOORE ERMEV: Synthetic benzhydryl alkamine ethers effective in preventing fatal experimental asthma in guinea pigs exposed to atomized histamine, Jr. Pharmacol. and Exper. Therap., 1945, lxxxiii, 120. Google Scholar38. STATEWANGENSTEEN DOH: Procaine intravenously in the treatment of delayed serum sickness, Jr. Am. Med. Assoc., 1946, cxxx, 990. CrossrefGoogle Scholar39. WEIL HR: Unusual side effect from benadryl, ibid., 1947, cxxxiii, 393. Google Scholar40. SCHWARTZBERGWILLERSON SD: Prolonged reaction to benadryl, ibid., 1947, cxxxiii, 393. Google Scholar41. BORMAN MC: Danger with benadryl of self medication and large dosage, ibid., 1947, cxxxiii, 394. Google Scholar42. GEIGERROSENFIELDHARTMAN JSZDL: Unusual reaction following benadryl administration, ibid., 1947, cxxxiii, 392. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: M.C. A.U.S. † Baltimore, Maryland*Received for publication April 21, 1947.From the Regional Station Hospital, Fort Belvoir, Virginia.†At Present visiting Fellow in Medicine, The Johns Hopkins University School of Medicine.‡Diphenhydramine hydrochloride, New and Non-official Remedies, 1947. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byA Danish Survey of Antihistamine Use and Poisoning PatternsDiphenhydramine and Dimenhydrinate Poisoning: an Evidence-Based Consensus Guideline for Out-of-Hospital ManagementDiphenhydramine-Induced Delirium in Elderly Hospitalized Patients With Mild DementiaFatality secondary to massive overdose of dimenhydrinateClinical Symptomatology of Diphenhydramine Overdose: An Evaluation of 136 Cases in 1982 to 1985Diphenhydramine-induced toxic psychosisAdverse effects of antihistaminesChanges in body temperature after administration of acetylcholine, histamine, morphine, prostaglandins and related agents: IILethal intoxication with diphenhydramineThe Effectiveness of Diphenhydramine HCI In Pediatric Sleep DisordersDrug-induced Psychoses and their Relationship to SchizophreniaSchizophrenia-like Psychosis Following ‘Mandrax’ OverdoseEEG findings following intravenous injection of diphenhydramine hydrochloride (benadrylR)Seltenere psychotrope SubstanzenAntihistaminikaAntihistaminikaAccidental fatal dibistine poisoningTreatment of acute benadryl (Diphenhydramine hydrochloride) intoxication with severe central nervous system changes and recoveryBIOCHEMICAL STUDIES ON DIPHENHYDRAMINE (BENADRYL) 1 July 1948Volume 29, Issue 1Page: 135-144KeywordsToxicity ePublished: 1 December 2008 Issue Published: 1 July 1948 PDF downloadLoading ...