tbuckley/cabot-search huggingface dataset:
Identification of different laminin binding proteins in basolateral cell membranes of human colorectal carcinomas and normal colonic mucosa.
Authors: A Stallmach, H H Riese, D Schuppan, G Bornhoft, H Stein, E O Riecken
Journal: Gut (1991)

The adhesive properties of tumour cells to laminin, the major glycoprotein of basement membranes, play a crucial part in the complex process of tumour invasion and metastasis. We therefore investigated the expression of laminin binding proteins in isolated basolateral cell membranes of human colorectal carcinomas and the adjacent normal colonic mucosa. Cell membrane binding assays and immunoblotting experiments showed appreciable quantitative and qualitative differences in the expression of these proteins in neoplastic and normal tissue. Epithelial basolateral cell membranes of colorectal carcinomas bound five to eight times more radioactive labelled laminin than basolateral cell membranes of the adjacent normal colonic epithelium. The expression of laminin binding proteins with Mr 66,000-69,000 daltons corresponding to the so called 'Mr 67,000 dalton laminin receptor' was three to four times higher in colorectal carcinomas than in normal colonic epithelium. In addition, laminin binding proteins with higher molecular weights, which may be related to the family of integrins, were also increased in colorectal carcinomas. In particular, laminin binding proteins with Mr 180,000 daltons were exclusively expressed on neoplastic epithelial cells of human colorectal carcinomas. Our data suggest that certain classes of laminin binding proteins may be selectively expressed on colonic tumour cells, leading to an increased capacity for migration, invasion, and metastasis.
“First AID” for T cell adoptive transfer: TCR affinity maturation by somatic hypermutation
Authors: Yosi M Gozlan, Esther Tzehoval, Lea Eisenbach
Journal: Journal for ImmunoTherapy of Cancer (2013)

Meeting abstracts Adoptive cell transfer (ACT) of tumor specific T lymphocytes, after host immunodepletion, was shown to mediate objective cancer regression of metastatic melanoma. Effective T cell activation depends, among other factors, on the functional avidity of the peptide-MHC complex (pMHC)
NITROFURANTOIN IN RENAL FAILURE
Authors: HAROLD W. GLASCOCK
Journal: Annals of Internal Medicine (1968)

Letters and Comments1 November 1968NITROFURANTOIN IN RENAL FAILUREHAROLD W. GLASCOCK JR., M.D.HAROLD W. GLASCOCK JR., M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-69-5-1077 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the Editor: In reading Dr. Calvin Kunin's interesting editorial note entitled "More on Antimicrobials in Renal Failure" (Ann. Intern. Med. 69: 397, 1968), I find the paragraph concerning nitrofurantoin contains a statement that deserves further explanation.While the studies of Dr. Kunin and Dr. Schlegel have clearly shown nitrofurantoin is poorly excreted by uremic patients and while it is true that neurotoxicity has been reported in uremic patients who received nitrofurantoin, it is believed the sentence that reads, "Accordingly, the drug appears to be contraindicated in the face of even moderate renal failure," is worthy of refinement as to... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byNitrofurantoin Contraindication in Patients with a Creatinine Clearance Below 60 mL/min: Looking for the EvidenceNNeural, hematologic and bacteriologic effects of nitrofurantoin in renal insufficiency 1 November 1968Volume 69, Issue 5Page: 1077-1077KeywordsAntimicrobialsDrugsRenal failure Issue Published: 1 November 1968 PDF downloadLoading ...
Accidental Poisoning and the Law
Authors: Joel J. Alpert
Journal: New England Journal of Medicine (1971)

The accidental ingestion of lye has been recognized for years as a major cause of acquired esophageal stricture in children. One would like to believe, therefore, that manufacturers of lye-containing household products would have been making efforts to reduce the toxicity of such products and the likelihood of their accidental ingestion. Unbelievably, exactly the opposite appears to have taken place (see page 578). Tragic is the only way to describe the unfortunate child victimized by a liquid caustic so toxic that the apparent mere licking of a cap permanently damaged her esophagus. Although this particular household product has now been . . .
Transplanted bone marrow mononuclear cells and MSCs impart clinical benefit to children with osteogenesis imperfecta through different mechanisms
Authors: Satoru Otsuru, Patricia L. Gordon, Kengo Shimono, Reena Jethva, Roberta Marino, Charlotte L. Phillips, Ted J. Hofmann, Elena Veronesi, Massimo Dominici, Masahiro Iwamoto, Edwin M. Horwitz
Journal: Blood (2012)
Pharmacologic Treatment of Alcohol Withdrawal
Authors: James R. Johnson
Journal: JAMA (1997)

To the Editor.  —In their meta-analysis, Dr Mayo-Smith and colleagues 1 stated that alcohol withdrawal occurred in a wide variety of settings but did not comment on the appropriateness of their suggested guidelines for outpatients vs inpatients. The authors noted that the Clinical Institute Withdrawal Assessment, Alcohol (CIWA-A) 2 and the CIWA-A, revised (CIWA-Ar) 3 had been used for patients admitted to the hospital (detoxification units, psychiatry units, and general hospital medical/surgical wards), but they did not specify whether these structured assessment scales had been used or were applicable to outpatient settings. Three of the 10 questions on the CIWA-A scale pertain to tactile, auditory, and visual hallucinations, 2 symptoms that often merit observation in inpatient rather than outpatient settings. 4 Thus, these scales might be more applicable to inpatient settings.  Symptom-triggered detoxification also might require modification for outpatients. In an outpatient setting, patients might not be assessed for symptoms of withdrawal as
HYPOGLYCEMIC SYMPTOMS PROVOKED BY REPEATED GLUCOSE INGESTION IN A CASE OF RENAL DIABETES
Authors: R. B. Gibson
Journal: JAMA (1924)

One of us (R. B. G.), in November last, reviewed the chemical findings in a case from our diabetic clinic before the Iowa Clinical Medical Society. Interest in the case centered in the fact that a final diagnosis of what was otherwise a case of pronounced renal diabetes could not be made because the sugar curve indicated a deficient glycogenesis of the mildly diabetic type. A study of the effects of a repeated ingestion of glucose on the sugar curve by Hamman and Hirschman<sup>1</sup>was recalled, and we predicted in our report that a decisive differentiation might be obtained if we employed the double sugar curve test in this case. The patient was requested to return for further observation, and promised to come to the clinic in January of this year. We have in the clinic, at the present time, a second patient with a fasting hypoglycemia and a
Polysymptomatic Conversion Disorder in Childhood and Adolescence in Japan
Authors: Satomi Murase, Toshiro Sugiyama, Takashi Ishii, Rie Wakako, Tatsuro Ohta
Journal: Psychotherapy and Psychosomatics (2000)

In conversion disorder in childhood and adolescence, polysymptomatic (PS) presentations are reportedly commoner than monosymptomatic (MS) ones. Somatization disorder is also associated with pseudoneurological symptoms, but is extremely rare in childhood. This occurs despite the age of onset peaking in the teens among adult somatization disorder patients.We reviewed the records of 44 children and adolescents with pseudoneurological symptoms. They were categorized as MS cases (19) or PS cases (25), and their psychological backgrounds and clinical courses were compared.PS patients had a poorer prognosis and more past psychiatric and family problems. While none met the DSM-IV criteria for somatization disorder, 2 PS patients met all but the sexual symptoms criteria.PS conversion disorder in childhood and adolescence may constitute a different entity from MS conversion disorder and may be an early manifestation or incomplete form of somatization disorder.
The Urgent Need to Improve Health Care Quality&lt;SUBTITLE&gt;Institute of Medicine National Roundtable on Health Care Quality&lt;/SUBTITLE&gt;
Authors: Mark R. Chassin
Journal: JAMA (1998)

To identify issues related to the quality of health care in the United States, including its measurement, assessment, and improvement, requiring action by health care professionals or other constituencies in the public or private sectors.The National Roundtable on Health Care Quality, convened by the Institute of Medicine, a component of the National Academy of Sciences, comprised 20 representatives of the private and public sectors, practicing medicine and nursing, representing academia, business, consumer advocacy, and the health media, and including the heads of federal health programs. The roundtable met 6 times between February 1996 and January 1998. It explored ongoing, rapid changes in health care and the implications of these changes for the quality of health and health care in the United States.Roundtable members held discussions with a wide variety of experts, convened conferences, commissioned papers, and drew on their individual professional experience.At the end of its deliberations, roundtable members reached consensus on the conclusions described in this article by a series of discussions at committee meetings and reviews of successive draft documents, the first of which was created by the listed authors and the Institute of Medicine project director. The drafts were revised following these discussions, and the final document was approved according to the formal report review procedures of the National Research Council of the National Academy of Sciences.The quality of health care can be precisely defined and measured with a degree of scientific accuracy comparable with that of most measures used in clinical medicine. Serious and widespread quality problems exist throughout American medicine. These problems, which may be classified as underuse, overuse, or misuse, occur in small and large communities alike, in all parts of the country, and with approximately equal frequency in managed care and fee-for-service systems of care. Very large numbers of Americans are harmed as a direct result. Quality of care is the problem, not managed care. Current efforts to improve will not succeed unless we undertake a major, systematic effort to overhaul how we deliver health care services, educate and train clinicians, and assess and improve quality.
Deficiency of complement-dependent prevention of immune precipitation in systemic sclerosis
Authors: G J Arason
Journal: Annals of the Rheumatic Diseases (2002)

Background: Previous studies have indicated that complement may be activated or inherently abnormal in systemic sclerosis (SSc), and it has been suggested that immune complex deposition plays a part in the microvascular damage of this disease. Objective: To study several aspects of the complement system in 24 patients with SSc. Methods: Complement dependent prevention of immune precipitation (PIP) was measured by a sensitive enzyme immunoassay, levels of C1q, C4, and C3 by rocket immunoelectrophoresis, C4 allotypes by high voltage agarose electrophoresis, and C4A, C4B, and C3d by an enzyme linked immunosorbent assay (ELISA). Results: PIP was markedly decreased in the patients with SSc (p&lt;0.001). Abnormal complement activation was detected in nine patients as raised levels of the complement split product C3d. However, a relation between low PIP and complement activation was not seen. PIP was significantly lower in patients who carried the C4A*Q0 allotype (p=0.03), and a strong correlation was found between PIP and C4A concentration (p&lt;0.00001). The PIP defect may, at least in some patients, be associated with the initial phase of the disease. Conclusions: The results show a previously unrecognised functional defect of complement in SSc; the defect correlates with low levels of classical pathway components and, in particular, C4A.
Proposed Rule Seeks to Safeguard Against Phased-Out Chemicals
Authors: Tracy Hampton
Journal: JAMA (2015)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Automatic Implantable Cardioverter Defibrillators and Survival of Patients with Left Ventricular Dysfunction and Malignant Ventricular Arrhythmias
Authors: Patrick J. Tchou
Journal: Annals of Internal Medicine (1988)

To assess survival after insertion of automatic implantable cardioverter defibrillators in high-risk patients who have malignant ventricular arrhythmias and left ventricular dysfunction.Actual survival time compared with arrhythmia-free time in a single group of patients.Inpatient services of a tertiary referral center and outpatient follow-up.Seventy consecutive patients with clinical sustained ventricular tachycardia or fibrillation whose arrhythmia could not be controlled by medication as determined by programmed electrical stimulation, and who had an automatic cardioverter defibrillator implanted.All patients received an implantable defibrillator.Two-year survival was 93.4% (95% CI, 87 to 99.8) and projected survival based on recurrence of malignant arrhythmias was 60.3% (CI, 47.3 to 73.3; P less than 0.001). In the 25 patients with left ventricular ejection fraction less than 30%, actual survival was 86.7% (CI, 72.3 to 91.1) and projected survival was 56.9% (CI, 35.9 to 77.9; P = 0.025). Projected survival percentages are similar to survival figures reported in the literature for such high-risk patients. There was only one sudden death; the remaining deaths were not arrhythmic in nature. Of the 65 patients who were alive at the end of follow-up, 13 were in New York Heart Association Class I; 44, Class II; 5, Class III; and 3, Class IV.The automatic implantable cardioverter defibrillator is probably highly effective in preventing arrhythmic mortality even in high-risk patients. Such treatment does not appear to significantly impair a patient's functional status.
Treatment of Ulcerative Colitis with Azathioprine
Authors: E. Theodor, E. Gilon, U. Waks
Journal: BMJ (1968)

Azathioprine (Imuran) was administered to seven patients with ulcerative colitis suffering from a relapse which could not be controlled by adrenocortical steroids. In four patients remission started one to two weeks after initiation of antimetabolite therapy. Corticosteroid administration was continued concurrently with azathioprine, but the dosage could be reduced and in one case they were withdrawn. Apart from transient leucopenia in two cases, and transient nausea and vomiting in two, no complications were encountered.
Letter: Tubal transplants.
Authors: P Steptoe
Journal: BMJ (1975)

An article discussing the possibility of tubal grafts states it may be a temporary solution sufficient to allow a pregnancy, but also states it may offer a permanent cure to severe tubal damage. Not only are these statements contradictory, but women with old pelvic inflammatory disease have not achieved successful uterine pregnancy, and have a high risk of ectopic pregnancy. In vitro fertilization and embryo transfer, on the other hand, can be repeated until pregnancy occurs. Both methods should be researched further since some patients are more suited to tubal transplant or to embryo transfer.
MORTALITY FROM CANCER
Authors: J. W. Schereschewsky
Journal: JAMA (1925)

<h3>To the Editor:</h3> —Referring to the editorial comment (The Journal, October 17, p. 1224) on my article on cancer mortality in the ten original registration states: In the course of the preparation of the bulletin of which this article is a summary, I, too, was struck by the apparent discrepancy between my conclusions for the ten original registration states and those arrived at by Dr. William T. Howard in his study of the statistics of the city of Baltimore (The Journal, Jan. 13, 1923, p. 71). This apparent discrepancy led me, of course, to careful study of Dr. Howard's article. From internal evidence in the article itself, it was apparent that the figures and the rates published were erroneous and, therefore, the conclusions based thereon could not be correct. In his article, Dr. Howard publishes the following table for the city of Baltimore: From his table the following conclusion is
Octreotide and opioids reduce the rate of proliferation of human hepatocellular carcinoma (HCC) cell line HEPG2, with parallel increase of nitric oxide (NO) production
Authors: G. Notas, M. Kampa, A. Vasilaki, C. Xidakis, V. Valatas, K. Thermos, G. Kolios, E. Custanas, E. Kouroumalis
Journal: Journal of Hepatology (2003)
A very rare presentation of miliary tuberculosis in mid-trimester pregnancy masquerading as sepsis and severe acute respiratory syndrome
Authors: Thomas Lavender, Victoria Robson, Manjusha Narayanan, Anne Barrett, Uli Schwab
Journal: Journal of Infection (2011)

We report a rare presentation of miliary tuberculosis (TB) in an HIV-negative pregnant Bangladeshi woman masquerading as acute sepsis with rapid progression to respiratory failure and acute respiratory distress syndrome (ARDS) and subsequent acute renal failure (ARF). The absence of any typical systemic prodromal symptoms, the short duration of illness and initially normal chest x-ray (CXR) with rapidly evolving radiological changes made ascertainment of the diagnosis of TB infection difficult. Aggressive investigation including liver and bone marrow biopsy lead to diagnostic confirmation, appropriate therapy, and, despite foetal loss at 22 weeks gestation, to a successful outcome.
Prevalence of Pre-Diabetes and Its Association With Clustering of Cardiometabolic Risk Factors and Hyperinsulinemia Among U.S. Adolescents
Authors: Chaoyang Li, Earl S. Ford, Guixiang Zhao, Ali H. Mokdad
Journal: Diabetes Care (2008)

Impaired fasting glucose (IFG) and/or impaired glucose tolerance (IGT) are considered to constitute "pre-diabetes." We estimated the prevalence of IFG, IGT, and pre-diabetes among U.S. adolescents using data from a nationally representative sample.We analyzed data from participants aged 12-19 years in the National Health and Nutrition Examination Survey 2005-2006. We used fasting plasma glucose and 2-h glucose during an oral glucose tolerance test to assess the prevalence of IFG, IGT, and pre-diabetes and used the log-binomial model to estimate the prevalence ratios (PRs) and 95% CIs.The unadjusted prevalences of IFG, IGT, and pre-diabetes were 13.1, 3.4, and 16.1%, respectively. Boys had a 2.4-fold higher prevalence of pre-diabetes than girls (95% CI 1.3-4.3). Non-Hispanic blacks had a lower rate than non-Hispanic whites (PR 0.6, 95% CI 0.4-0.9). Adolescents aged 16-19 years had a lower rate than those aged 12-15 years (0.6, 0.4-0.9). Overweight adolescents had a 2.6-fold higher rate than those with normal weight (1.3-5.1). Adolescents with two or more cardiometabolic risk factors had a 2.7-fold higher rate than those with none (1.5-4.8). Adolescents with hyperinsulinemia had a fourfold higher prevalence (2.2-7.4) than those without. Neither overweight nor number of cardiometabolic risk factors was significantly associated with pre-diabetes after adjustment for hyperinsulinemia.Pre-diabetes was highly prevalent among adolescents. Hyperinsulinemia was independently associated with pre-diabetes and may account for the association of overweight and clustering of cardiometabolic risk factors with pre-diabetes.
Non‐Hodgkin's lymphoma and other nonhepatic malignancies in Swedish patients with hepatitis C virus infection†
Authors: Ann‐Sofi Duberg, Marie Nordström, Anna Törner, Olle Reichard, Reinhild Strauss, Ragnhild Janzon, Erik Bäck, Karl Ekdahl
Journal: Hepatology (2005)

The aim of this study was to evaluate the association between hepatitis C virus (HCV) infection and non-Hodgkin's lymphoma (NHL), multiple myeloma (MM), thyroid cancer (TC), chronic lymphatic leukemia (CLL), acute lymphatic leukemia (ALL), and Hodgkin's lymphoma (HL). A Swedish cohort of 27,150 HCV-infected persons notified during 1990-2000 was included in the study. The database was linked to other national registers to calculate the observation time, expressed as person-years, and to identify all incident malignancies in the cohort. The patients were stratified according to assumed time of previous HCV infection. The relative risk of malignancy was expressed as a standardized incidence ratio (SIR)—the observed number compared to the expected number. During 1990-2000 there were 50 NHL, 15 MM, 14 ALL, 8 TC, 6 CLL, and 4 HL diagnoses in the cohort. Altogether, 20 NHL, 7 MM, 5 TC, 4 CLL, 1 ALL, and 1 HL patient fulfilled the criteria to be included in the statistical analysis. The observation time was 122,272 person-years. The risk of NHL and MM was significantly increased in the stratum with more than 15 years of infection (SIR 1.89 [95% CI, 1.10-3.03] and 2.54 [95% CI, 1.11-5.69], respectively). The association was not significant in TC or CLL. In conclusion, we report the incidence of several malignancies in a nationwide cohort of HCV-infected persons. Although the delayed diagnosis of HCV probably has resulted in an underestimation of the risk, this study showed a significantly increased risk of NHL and MM. (HEPATOLOGY 2005;41:652–659.)