tbuckley/cabot-search huggingface dataset:
Abstract P421: Estimation Of Adult Dietary Sodium Intake And Source In Shandong China 2011: Finding From SMASH Project Baseline Survey
Authors: Liuxia YAN, Zilong LU, Jixiang MA, Xiaolei GUO, Jiyu ZHANG, Junli TANG, Huicheng WANG, Xiaoning CAI
Journal: Circulation (2014)

Zilong LU, Liuxia YAN, Jixiang MA, Xiaolei GUO, Jiyu ZHANG, Junli TANG, Huicheng WANG, Xiaoning CAI Background: Moderate population salt reduction could reduce blood pressure and the cardiovascular and stroke mortality in the long-term. In 2002, China’s national average dietary salt intake is twice of the recommendation sodium intake limit by Chinese Nutrition Association. To tackle the health burden of excessive salt intake, the former Ministry of Health has chosen Shandong province as national pilot and launched the Shandong &amp; Ministry of Health Action on Salt and Hypertension (SMASH, 2011[[Unable to Display Character: &amp;#8211;]]2015) project. Objective: To develop and target intervention priority, a cross-sectional population survey was conducted to collect baseline data on sodium intake and sources in Shandong adults in 2011. Methods: We used multi-stage clustering sampling method to select the provincial representative sample for Shandong adults aged 18~69 years old. The selected adults were invited to participate the questionnaire survey and consecutive three-round 24-hour dietary recall. The Chinese 24-hour dietary recall includes two parts, cooking condiment weighting and the food (exclude the condiment) intake diary. The sodium contents in the condiments and food were calculated by using reference values from China Food Composition 2004. Results: Overall, 2140 community adult residents were included in the data analysis. The total average dietary sodium intake estimated by 24-hour dietary recall was 5745mg (95%CI: 5428-6063). Men (6147mg/d, 5824-6471) consumed higher sodium than women (5339 mg/d, 5006-5673) (P&lt;0.05). The majority of dietary sodium (81%) was from cooking condiments including salt, soy sauce, sauce and monosodium glutamate (MSG), with a mean sodium intake of 4640mg (4360-4920). Out of the cooking condiments, salt added during food preparation was the leading source (63%) of sodium intake, up to 3638mg/d (3397-3879) sodium intake. Sodium intake from processed food was account for 10% of the total sodium intake, averaged at 582 mg (498-666) sodium intake for Shandong adults. Conclusion: The Shandong adults consume excessive sodium than the recommendation intake and most is from the condiments added at cooking.
Respiratory morbidity of children exposed to crocidolite at Wittenoom, Western Australia
Authors: Peter Franklin, Alison Reid, Latha Samuel, Nicholas de Klerk, Bill Musk
Journal: European Respiratory Journal (2011)

Little is known about the general respiratory health of people exposed to asbestos in childhood. This study investigated respiratory symptoms and lung function in subjects who lived in an asbestos mining town (Wittenoom) as children. Lung function (spirometry), chest x-ray, and respiratory symptom data from former Wittenoom children who participated in an Asbestos Review Program (ARP) were assessed. Symptom frequencies and predicted FVC, FEV1 and FEV1/FVC were calculated. Predictors of increased symptoms and poor lung function were assessed using linear and logistic regression. 386 individuals of the ARP had been children when living in Wittenoom. Of these, 8 had developed mesothelioma, 2 lung cancer, 14 radiographic asbestosis and 3 diffuse pleural thickening. These participants were excluded from the analyses. The median age of arrival was 2.3 (IQR 0.6 – 6.0) years and the median duration of residence was 24 (12 - 48) months. The mean age at assessment was 48.5 (SD 9.3) years. About 25% were past smokers and 22.7% still smoked at the time of the assessment. Reported symptoms included; cough (15.7%), phlegm (11.6%), dyspnea (18.3%), wheeze ever (20.1%) and asthma ever (20.8%). The main predictor for increased symptoms was current smoking. Mean (SD) predicted FVC, FEV1 and FEV1/FVC were 90.6% (21.4), 90.1% (20.4) and 79.5% (2.1), respectively. Age at time of test, age at 1st exposure and cumulative asbestos exposure were associated with both reduced FVC and FEV1. Age at time of test, being male and asthma were associated with decreased FEV1/FVC. Asbestos exposure as a child is associated with sub-clinical restrictive lung function decrements even in the absence of radiographic abnormalities.
Abstract 12807: Severity of Sleep-Disordered Breathing Has an Impact on the Frequency of Nocturnal Enuresis ~ The Challenge With Continuous Positive Airway Pressure to Stop Nocturnal Enuresis in Cardiovascular Patients ~
Authors: Sunao Kojima, Takashi Miyazaki, Seiji Hokimoto, Hisao Ogawa
Journal: Circulation (2014)

Introduction:  Nocturnal enuresis (NE) is an essential issue and the cause is multifactorial in patients with advanced age. Continuous positive airway pressure (CPAP) is the first-line treatment for patients with symptomatic obstructive sleep apnea (OSA).   Hypothesis:  We assessed the hypothesis that NE was associated with sleep-disordered breathing (SDB) and evaluated the effect of CPAP treatment on the frequency of NE in OSA patients with cardiovascular disease.   Methods:  A spectrophotometry of oxygen saturation with a built-in memory device was performed in consecutive 546 patients with cardiovascular disease who were electively hospitalized. A total of 36 patients (35 patients with artificial dialysis and 1 patient with no clinical data) were excluded in this study. The remaining 510 patients were divided into NE (n=433) and non-NE (n=77) groups.   Results:  Frequency of nocturnal urination was positively correlated with 3% oxygen desaturation index (ODI), suggesting the severity of SDB (r=0.271, P 4 hours during asleep almost every night.   Conclusions:  NE is frequently observed in SDB patients. Our findings may help to explain the missing link between pathophysiological aggravation of NE and SDB associated cardiovascular risks such as hypertension and heart failure. These are improved by the treatment with CPAP, which may be beneficial in men with advanced age suffering from cardiovascular disease with NE.
Abstract 13871: MiR-146a-induced Inhibition of Neuregulin1-ErbB4 Pathway may be Involved in Deterioration of Cardiotoxicity under Concurrent Chemotherapy with Doxorubicin and Trastuzumab.
Authors: Takahiro Horie, Koh Ono, Hitoo Nishi, Kazuya Nagao, Minako Kinoshita, Shin Watanabe, Yasuhide Kuwabara, Yasuhiro Nakashima, Rieko Takanabe-Mori, Eiichiro Nishi, Koji Hasegawa, Toru Kita, Takeshi Kimura
Journal: Circulation (2010)
Fetal Microchimeric Cells and Breast Cancer
Authors: Richard C Frank
Journal: JAMA (2004)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Handbuch der Physiologie der niederen Sinne.
Authors: Emil von. Skramlik
Journal: JAMA (1926)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The Natural Increase of Mankind.
Authors: James Shirley Sweeney
Journal: JAMA (1926)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Arthritis Puzzle: Two Pieces Snap Into Place
Authors: Brian Vastag
Journal: JAMA (2002)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Identification of systemic G1/S cell cycle regulation of Apicidin, a histone deacetylase inhibitor, in breast cancer cells through large-scale gene expression analysis
Authors: Ji Heon Noh, Jaehwi Song, Jung Woo Eun, Jeong Kyu Kim, Kwang Hwa Jung, Su Young Kim, Sug Hyung Lee, Won Sang Park, Nam Jin You, Jung Young Lee, Suk Woo Nam
Journal: Clinical Cancer Research (2007)

B51   Apicidin, a histone deacetylase (HDAC) inhibitor that originally isolated as anti-fungal angent, has been investigated to have potent anti-proliferative activity and potentate apoptosis in various cancer cells. Since HDACs have been challenged as promising targets of cancer therapy and some HDAC inhibitors are in clinical trial, it is important to understand systemic inhibitory mechanisms induced by targeted-interruption of HDACs in tumor cells. Thus, to understand comprehensive transcriptomic changes by HDAC inhibition, we analyzed global expression profiles of MDA-MB-435 breast cancer cells treated with Apicidin in a time-dependent manner, and dissected inhibitory mechanisms on cell-cycle regulation by Apicidin through data driven pathway analysis of microarray works. As consequence, total 631 outlier genes were identified as continuously up- or down regulated genes during Apicidin treatment. Most of biological processes involved in outlier genes are cell-cycle, apoptosis, signal transduction, transcription regulation and metabolism. Among these, complicated negative cell-cycle regulation by Apicidin was systemically dissected from data mining and validated through biological assay. In conclusion, we are able to dissect the comprehensive inhibitory circuit of cell-cycle caused by Apicidin, a potent HDAC inhibitor, in breast cancer cells through large-scale DNA microarray data interpretation. Recapitulated genetic elements herein also provide promising therapeutic interventions for new anticancer drugs in breast cancer.
Textbook of Respiratory Medicine.
Authors: [edited by] John F. Murray, Jay A. Nadel
Journal: Annals of Internal Medicine (1988)

This book presents a clinical reference of respiratory medicine. It also details basic science aspects of pulmonary physiology and describes recently developed, sophisticated diagnostic tools and therapeutic methods. It also covers anatomy, physiology, pharmacology, and pathology; microbiologic, radiologic, nuclear medicine, and biopsy methods for diagnosis.
Learning Enhances Sensory and Multiple Non-sensory Representations in Primary Visual Cortex
Authors: Jasper Poort, Adil G. Khan, Marius Pachitariu, Abdellatif Nemri, Ivana Orsolic, Julija Krupic, Marius Bauza, Maneesh Sahani, Georg B. Keller, Thomas D. Mrsic-Flogel, Sonja B. Hofer
Journal: Neuron (2015)

We determined how learning modifies neural representations in primary visual cortex (V1) during acquisition of a visually guided behavioral task. We imaged the activity of the same layer 2/3 neuronal populations as mice learned to discriminate two visual patterns while running through a virtual corridor, where one pattern was rewarded. Improvements in behavioral performance were closely associated with increasingly distinguishable population-level representations of task-relevant stimuli, as a result of stabilization of existing and recruitment of new neurons selective for these stimuli. These effects correlated with the appearance of multiple task-dependent signals during learning: those that increased neuronal selectivity across the population when expert animals engaged in the task, and those reflecting anticipation or behavioral choices specifically in neuronal subsets preferring the rewarded stimulus. Therefore, learning engages diverse mechanisms that modify sensory and non-sensory representations in V1 to adjust its processing to task requirements and the behavioral relevance of visual stimuli.
Is Alzheimer’s disease inevitable with age?
Authors: John C. Morris
Journal: Journal of Clinical Investigation (1999)

The unprecedented and growing number of older adults in the US and other developed countries has crystallized scientific interest in the health consequences of aging.Perhaps the most feared of these consequences is Alzheimer's disease (AD).As the leading cause of dementia, AD not only extracts a terrible toll from patients and their families but is an enormous public health burden, with annual costs in the US alone approaching 100 billion dollars.The major risk factor for AD is living longer; AD prevalence doubles every 5 years after age 65 and approaches 50% by age 85 (1).Some epidemiologists report that the prevalence of AD continues to increase in the very old and conclude that "AD ... may become universal when age is sufficiently advanced" (2).As we enter the 21st century with increasing life expectancies, the obvious question becomes, "If we live long enough, will we all be demented?"(3).Although this question cannot be definitely resolved at present, accumulating evidence suggests that not all of us will.Before reviewing the data that led me to consider aging and AD as discrete rather than continuous processes, I should acknowledge 3 biases.First, I believe that for studies of cognitive aging, longitudinal study designs are preferable to cross-sectional designs, which may be confounded by cohort effects that overestimate
Plan B for "Plan B"?
Authors: Brian Vastag
Journal: JAMA (2004)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Abstract 3952: Recurrent prostate cancer genomic alterations predict response to brachytherapy treatment
Authors: Jacqueline Fontugne, Daniel Lee, Chiara Cantaloni, Christopher E. Barbieri, Caffo Orazio, Esther Hanspeter, Guido Mazzoleni, Paolo Dalla Palma, Mark A. Rubin, Giovanni Fellin, Juan Miguel Mosquera, Mattia Barbareschi, Francesca Demichelis
Journal: Cancer Research (2014)

Abstract Background Discovery of ERG rearrangements and recurrent associated molecular alterations, such as PTEN deletions, has helped understand prostate carcinogenesis. However, prostate cancer (PCa) molecular stratification has not been well studied in response to different treatment modalities. The objective of this study was to evaluate the association of ERG rearrangements and PTEN deletions with oncologic outcomes in PCa patients treated with brachytherapy. Material and methods Ninety-two men underwent I-125 brachytherapy with a 145Gy delivered dose between 2000 and 2008. Pre-treatment prostate biopsies were analyzed by immunohistochemistry (IHC) and fluorescence in situ hybridization (FISH) for ERG rearrangement and overexpression, PTEN deletion and expression loss. Univariable and multivariable Cox-regression analyses evaluated association of ERG and PTEN status with biochemical recurrence (BCR). Results Within a median follow-up of 73 months, 11% of patients experienced BCR. Of 80 samples with both IHC and FISH performed for ERG, 46 (57.8%) demonstrated rearrangement by FISH and 45 (56.3%) by IHC. Of 77 samples with both IHC and FISH for PTEN, 14 (18.2%) had PTEN deletion by FISH and 22 (28.6%) by IHC. No significant associations were found between ERG, PTEN status and clinicopathologic features. Patients with concurrent ERG rearrangement and PTEN deletion demonstrated significantly worse relapse-free survival rates compared to those with ERG or PTEN wild-type (p&amp;lt;0.01). In multivariable Cox regression analysis adjusted for the effects of standard clinicopathologic features, combined ERG rearranged and PTEN deletion was independently associated with BCR (HR 2.6, p=0.02). Conclusions Concurrent ERG rearrangement and PTEN loss was independently associated with time to BCR in patients undergoing brachytherapy. Identifying patients in this molecular subclass may improve treatment personalization. Future studies are needed to validate PCa molecular subtyping for risk-stratification. Citation Format: Jacqueline Fontugne, Daniel Lee, Chiara Cantaloni, Christopher E. Barbieri, Caffo Orazio, Esther Hanspeter, Guido Mazzoleni, Paolo Dalla Palma, Mark A. Rubin, Giovanni Fellin, Juan Miguel Mosquera, Mattia Barbareschi, Francesca Demichelis. Recurrent prostate cancer genomic alterations predict response to brachytherapy treatment. [abstract]. In: Proceedings of the 105th Annual Meeting of the American Association for Cancer Research; 2014 Apr 5-9; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2014;74(19 Suppl):Abstract nr 3952. doi:10.1158/1538-7445.AM2014-3952
Abstract P2-01-28: Prognosis of metastatic internal mammary sentinel nodes (IMSN) in breast cancer
Authors: Eli Avisar, Shai Libson, Eduardo Perez
Journal: Cancer Research (2015)

Abstract Introduction: The presence of positive internal mammary nodes has historically been associated with a significant worse prognosis. Recent studies have also demonstrated a worse prognosis associated with drainage to the internal mammary nodes. Intense search for those nodes, biopsy, appropriate staging and modern treatment for positive IMSN might improve outcome. We sought to study the prognosis of pathologically positive IMSN at our institution. Methods: A retrospective analysis of a prospectively collected database including all breast cancer patients identified with an IMSN that was biopsied between 2005 and 2012 was performed. Demographics, histologic markers, patterns of recurrence as well as survival data were collected. Univariate and multivariate analysis were performed. Results: Thirteen of 82 patients with a biopsied IMSN were metastatic (16%). In 8 of those (62%), the biopsy resulted in a change in staging. In all cases of positive IMSN additional radiation to the internal mammary chain was added. Eighteen percent (18%) of positive nodes did not show drainage to the internal mammary basin during Lymphoscintigraphy. There was no statistical difference in regional and distant recurrences between the patients with positive IMSN and those with negative IMSN. Furthermore there was no difference in disease specific survival. Conclusions: Intense search for IMSN presence and biopsy of those nodes is associated with changes in staging and treatment for metastatic IMSN. In our study, pathologically positive IMSN were associated with a non- inferior prognosis than negative IMSN. Citation Format: Eli Avisar, Shai Libson, Eduardo Perez. Prognosis of metastatic internal mammary sentinel nodes (IMSN) in breast cancer [abstract]. In: Proceedings of the Thirty-Seventh Annual CTRC-AACR San Antonio Breast Cancer Symposium: 2014 Dec 9-13; San Antonio, TX. Philadelphia (PA): AACR; Cancer Res 2015;75(9 Suppl):Abstract nr P2-01-28.