HYPERCALCEMIA OF MALIGNANT DISEASE: CASE REPORT AND A PROPOSED MECHANISM OF ETIOLOGY
Authors: Gerald E. Stone, Christine Waterhouse, Roger Terry
Journal: Annals of Internal Medicine (1961)

Case Reports1 May 1961HYPERCALCEMIA OF MALIGNANT DISEASE: CASE REPORT AND A PROPOSED MECHANISM OF ETIOLOGYGERALD E. STONE, M.D., CHRISTINE WATERHOUSE, M.D., F.A.C.P., ROGER TERRY, M.D.GERALD E. STONE, M.D.Search for more papers by this author, CHRISTINE WATERHOUSE, M.D., F.A.C.P.Search for more papers by this author, ROGER TERRY, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-54-5-977 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptHypercalcemia, as one of the manifestations of malignant disease, has become a well recognized phenomenon during recent years. In 1953 Woodard1reported that about nine per cent of patients with metastases to bones from primary sites other than the prostate showed elevations of total serum calcium. Myers2, 3has found high serum calcium levels frequently associated with carcinoma of the lung, breast, and kidney, in addition to multiple myeloma and the lymphomas. Other tumors that have been associated with hypercalcemia include malignant lesions of the stomach, cervix, urinary bladder, uterus, tonsils, cartilage, and neuroblastomas. As will be discussed later, the...Bibliography1. Woodard HO: Changes in blood chemistry associated with carcinoma metastatic to bone. Cancer 6: 1219-1227, 1953. CrossrefMedlineGoogle Scholar2. Myers WP: Hypercalcemia in neoplastic disease. Cancer 9: 1135-1140, 1956. CrossrefMedlineGoogle Scholar3. Myers WP: Hypercalcemia in neoplastic disease. Arch. Surg. 80: 308-318, 1960. CrossrefMedlineGoogle Scholar4. ThomasWiswellConnorHoward WCJGTBJE: Hypercalcemic crisis due to hyperparathyroidism. Amer. J. Med. 24: 229-239, 1958. CrossrefMedlineGoogle Scholar5. 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LongcopeFreiman WTDG: A study of sarcoidosis. Medicine 31: 1-132, 1952. CrossrefMedlineGoogle Scholar17. AndersonDentHarperPhilpot JCECGR: Effect of cortisone on calcium metabolism of sarcoidosis with hypercalcemia: possibly antagonistic actions of cortisone and vitamin D. Lancet 2: 720-724, 1954. CrossrefGoogle Scholar18. HennemanCarrollDempsey PHELEF: Mechanism responsible for hypercalcuria in sarcoid. J. Clin. Invest. 33: 941, 1954. Google Scholar19. HennemanDempseyCarrollAlbright PHEFELF: Cause of hypercalcuria in sarcoid and its treatment with cortisone and sodium phytate. J. Clin. Invest. 35: 1229-1242, 1956. CrossrefMedlineGoogle Scholar20. Case Records of the Massachusetts General Hospital (Case 37091). New Engl. J. Med. 244: 333-339, 1951. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Rochester, New York*Received for publication August 26, 1960.From the Departments of Medicine and Pathology, University of Rochester School of Medicine and Dentistry, Rochester, N. Y.†This study was aided by Grant P-138 from the American Cancer Society.Dr. Stone is an Assistant in Medicine and Associate Resident in Medicine, Strong Memorial Hospital; Dr. Waterhouse is an Associate Professor of Medicine, University of Rochester School of Medicine and Dentistry; Dr. Terry is an Associate Professor of Pathology, University of Rochester School of Medicine and Dentistry.Requests for reprints should be addressed to Christine Waterhouse, M.D., Strong Memorial Hospital, 260 Crittenden Boulevard, Rochester 20, N. Y. 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H. 1 May 1961Volume 54, Issue 5Page: 977-985KeywordsCalciumDentistryHospital medicineHypercalcemiaLymphomaMultiple myelomaNeuroblastomaStomachTonsilsUterus ePublished: 1 December 2008 Issue Published: 1 May 1961 PDF downloadLoading ...