tbuckley/cabot-search huggingface dataset:
P69 Mesothelioma in the 21st century. A 1-year survey of malignant mesothelioma in the South West of the UK
Authors: R. Bhatnagar, S. Earl, K. Lansdell, T. J. Howell
Journal: Thorax (2010)

<h3>Introduction</h3> Malignant mesothelioma (MM) is a cancer that most commonly arises within the pleura, and carries a poor prognosis. There is a strong association with past asbestos exposure so incidence varies across the UK. In the South West of the UK there is a high incidence with many cases being due to asbestos exposure in the ship-building industry. <h3>Aims</h3> To describe the demographics, treatment strategies and survival of patients presenting with MM across the Peninsula cancer network, a population of around 1.7 million people, over a 1-year period. <h3>Method</h3> Cases of MM diagnosed in 2007 were identified retrospectively and reviewed following interrogation of cancer, MDT, pathology and post mortem databases for the five hospitals in the network. A full review of the clinical records was performed. <h3>Results</h3> 81 patients were identified. Average age was 72 and 94% were male. 82.7% of patients had a performance status of 0 or 1 at presentation but 21% had a significant co-morbidity, most commonly cardiac in nature. 77.8% of patients had definite or probable asbestos exposure. At presentation symptoms had been present for a mean of 3.7 months, the commonest being breathlessness and chest pain. A definitive diagnosis was made in 84% of patients, either on histology (75%) or cytology (9%) and the epithelioid subtype was most common (40.7% of cases). VATS was the main diagnostic modality (61.7%). Despite 61.7% of patients technically being fit for chemotherapy, only 29.6% received it. Mean survival was 269 days (8.8 months). Survival was longer in those with a better performance status at presentation (PS0=344 days, PS1=270d, PS2=125d, PS3=89d), and in those who received chemotherapy (448d vs 269d). <h3>Conclusion</h3> MM remains a common problem in the South West of the UK. Despite recent treatment advances the prognosis remains poor, with our survival data being similar to that described in earlier population based studies and in chemotherapy treatment trials. Only a small proportion of our patients received chemotherapy and this may reflect the lack of NICE guidance for use of pemetrexed which was only issued in 2008. However, those patients who recieved chemotherapy had a better survival time (14.7 months vs 8.8 month).
ADENOSINE TRIPHOSPHATASE IN AN ORAL EPITHELIAL NAEVUS
Authors: L. COHEN, A. H. YOUNG, R. A. KIMBER
Journal: British Journal of Dermatology (1967)

Journal Article ADENOSINE TRIPHOSPHATASE IN AN ORAL EPITHELIAL NAEVUS Get access L. COHEN, Ph.D., B.Ch.D., F.D.S., M.R.C.S., L.R.C.P., L. COHEN, Ph.D., B.Ch.D., F.D.S., M.R.C.S., L.R.C.P. Departments of Oral Medicine and Oral Surgery, Institute of Dental Surgery, Gray's Inn Road, London, W.C.1 Search for other works by this author on: Oxford Academic Google Scholar A. H. YOUNG, B.D.S., F.D.S., M.R.C.S., L.R.C.P., A. H. YOUNG, B.D.S., F.D.S., M.R.C.S., L.R.C.P. Departments of Oral Medicine and Oral Surgery, Institute of Dental Surgery, Gray's Inn Road, London, W.C.1 Search for other works by this author on: Oxford Academic Google Scholar R. A. KIMBER R. A. KIMBER Departments of Oral Medicine and Oral Surgery, Institute of Dental Surgery, Gray's Inn Road, London, W.C.1 Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 79, Issue 12, 1 December 1967, Pages 699–703, https://doi.org/10.1111/j.1365-2133.1967.tb11440.x Published: 01 December 1967
Monitoring of Minimal Residual Disease After Allogeneic Stem-Cell Transplantation in Relapsed Childhood Acute Lymphoblastic Leukemia Allows for the Identification of Impending Relapse: Results of the ALL-BFM-SCT 2003 Trial
Authors: Peter Bader, Hermann Kreyenberg, Arend von Stackelberg, Cornelia Eckert, Emilia Salzmann-Manrique, Roland Meisel, Ulrike Poetschger, Daniel Stachel, Martin Schrappe, Julia Alten, Andre Schrauder, Ansgar Schulz, Peter Lang, Ingo Müller, Michael H. Albert, Andre M. Willasch, Thomas E. Klingebiel, Christina Peters
Journal: Journal of Clinical Oncology (2015)

To elucidate the impact of minimal residual disease (MRD) after allogeneic transplantation, the Acute Lymphoblastic Leukemia Berlin-Frankfurt-Münster Stem Cell Transplantation Group (ALL-BFM-SCT) conducted a prospective clinical trial.In the ALL-BFM-SCT 2003 trial, MRD was assessed in the bone marrow at days +30, +60, +90, +180, and +365 after transplantation in 113 patients with relapsed disease. Standardized quantification of MRD was performed according to the guidelines of the Euro-MRD Group.All patients showed a 3-year probability of event-free survival (pEFS) of 55%. The cumulative incidence rates of relapse and treatment-related mortality were 32% and 12%, respectively. The pEFS was 60% for patients who received their transplantations in second complete remission, 50% for patients in ≥ third complete remission, and 0% for patients not in remission (P = .015). At all time points, the level of MRD was inversely correlated with event-free survival (EFS; P < .004) and positively correlated with the cumulative incidence of relapse (P < .01). A multivariable Cox model was fitted for each time point, which showed that MRD ≥ 10(-4) leukemic cells was consistently correlated with inferior EFS (P < .003). The accuracy of MRD measurements in predicting relapse was investigated with time-dependent receiver operating curves at days +30, +60, +90, and +180. From day +60 onward, the discriminatory power of MRD detection to predict the probability of relapse after 1, 3, 6, and 9 months was more than 96%, more than 87%, more than 71%, and more than 61%, respectively.MRD after transplantation was a reliable marker for predicting impending relapses and could thus serve as the basis for pre-emptive therapy.
Cat (<i>Fel d</i> I), dog (<i>Can f</i> I), and cockroach allergens in homes of asthmatic children from three climatic zones in Sweden
Authors: A. K. M. Munir, B. Björkstén, R. Einarsson, C. Schou, A. Ekstrand‐Tobin, A. Warner, N.‐I. M. Kjellman
Journal: Allergy (1994)

We have investigated the levels of cat (Fel d I), dog (Can f I), and cockroach (Per a I) allergens in dust from bedrooms, living rooms, kitchens, and bathrooms from 123 homes of asthmatic children in three zones of Sweden with varying climates. Absolute indoor humidity (AIH), relative humidity (RH), rate of ventilation in air changes per hour (ach), and number of airborne particles were also measured. Fel d I, Can f I, and Per a I allergen contents were determined by mab ELISA, and the levels were related to various environmental factors. The major cat allergen, Fel d I, was detected in all homes, and the concentrations varied between 16 ng and 28,000 ng/g fine dust. The dog allergen, Can f I, was detected in 85% of the homes, and the levels varied from 60 ng to 866,000 ng/g dust. Cockroach allergen was detected in only one home (40 ng/g). Fel d I and Can f I allergens were equally distributed geographically. Dust from living rooms contained significantly higher (P < 0.05) concentrations of both Fel d I and Can f I allergens than dust from bedrooms, kitchens, and bathrooms. The levels tended to be higher in homes with poor ventilation (< 0.5 ach) and in homes with wall-to-wall carpets. Significantly higher (P < 0.01) numbers of airborne particles were found in homes with high humidity (i.e., AIH > or = 7 g/kg or RH > or = 45%).(ABSTRACT TRUNCATED AT 250 WORDS)
Case 5-1989
Authors: Richard C. Cabot, Robert E. Scully, Eugene J. Mark, William F. McNeely, Betty U. McNeely, P.A. Banks, A.E. Rosenberg
Journal: New England Journal of Medicine (1989)

Presentation of CaseA 27-year-old woman was admitted to the hospital because of portal-vein thrombosis and an epigastric mass.The patient was well until 10 days earlier, when moderately severe epigastric pain developed; she was able to continue her work, and the pain diminished during the day. On the following day, after she drank milk, the pain became constant and very severe and radiated around to the back in a band-like fashion; nausea and vomiting occurred. She was admitted to another hospital, where evaluation revealed a normal amylase level. An x-ray film of the abdomen was reported to show calcification . . .
FIBROUS CHANGES IN THE DERMIS, WITH SPECIAL REFERENCE TO SENILE ELASTOSIS
Authors: G. H. PERCIVAL, P. W. HANNAY, D. A. DUTHIE
Journal: British Journal of Dermatology (1949)

Journal Article FIBROUS CHANGES IN THE DERMIS, WITH SPECIAL REFERENCE TO SENILE ELASTOSIS Get access G. H. PERCIVAL, M.D., Ph.D., F.R.C.P.E., D.P.H., G. H. PERCIVAL, M.D., Ph.D., F.R.C.P.E., D.P.H. Department of Dermatology, University of Edinburgh Search for other works by this author on: Oxford Academic Google Scholar P. W. HANNAY, M.B., Ch.B., P. W. HANNAY, M.B., Ch.B. Department of Dermatology, University of Edinburgh Search for other works by this author on: Oxford Academic Google Scholar D. A. DUTHIE, M.B., Ch.B., M.R.C.P.E. D. A. DUTHIE, M.B., Ch.B., M.R.C.P.E. Department of Dermatology, University of Edinburgh Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology and Syphilis, Volume 61, Issue 8-9, 1 August 1949, Pages 269–276, https://doi.org/10.1111/j.1365-2133.1949.tb11099.x Published: 01 August 1949
Meningitis Due to Lymphocytic Choriomeningitis Virus Endemic in a Hamster Colony
Authors: Donald Armstrong
Journal: JAMA (1969)

Meningitis due to lymphocytic-choriomeningitis (LCM) virus occurred in a 36-year-old man after brief contact with infected hamsters. To our knowledge, this is the second instance of an LCM infection developing in a man exposed to hamsters used for experimental tumor investigation.
Home Inhalation Equipment For Less Than $10
Authors: Thomas L. Petty
Journal: JAMA (1966)

<h3>To the Editor:—</h3> Nebulized bronchodilators and steam are useful to provide effective bronchial hygiene in many patients with chronic obstructive lung disease (emphysema and chronic bronchitis). The bronchodilator drug is indicated to combat bronchial mucosal edema and smooth muscle spasm (bronchospasm). Inhalation of steam helps moisturize and thin secretions to provide ease in removal by coughing or in-bed postural drainage maneuvers. This type of sequential therapeutic program is the mainstay of home management for many patients with marked airway resistance caused both by bronchospasm and by retained secretions. The available equipment designed to power nebulizers (pump and intermittent positive pressure respirator [IPPR] and humidifiers is excellent in design, but expensive. Simple hand bulb nebulizers require the patient's coordination and some degree of strength; sufficient hand strength is lacking in many patients who are chronically ill, and pain is a problem in patients with inflammatory arthritis. The adaptation of a tire
Comparison of arm and leg ergometry in patients with moderate chronic obstructive lung disease.
Authors: G R Owens, F E Thompson, F C Sciurba, R Robertson, K F Metz, R R Volmer
Journal: Thorax (1988)

Exercise testing is traditionally performed with leg exercise on either a treadmill or a bicycle ergometer. Many of these tests are terminated before dyspnoea occurs because of leg fatigue, arthritic pain, or claudication. A study was carried out to determine whether arm ergometry testing might serve as an alternative method to leg testing in eight patients with chronic obstructive lung disease. The patients had mild to moderate dyspnoea on exertion and required bronchodilator treatment. They had smoked an average of 62 pack years and had a mean FEV1 of 1.88 l. Arm and leg ergometry yielded similar levels of maximum ventilation (arm 47.2, leg 48.6 l/min), maximum heart rates (126 v 124 beats/min), maximum tidal volume (1.5 v 1.6 l), and respiratory rate (30 v 29 breaths/min); but maximum oxygen consumption (1120 v 966 ml/min), maximum power output (62 v 26 w), and oxygen pulse (9.1 v 7.8 ml/beat) were all higher with leg than with arm ergometry. In addition, ventilation and heart rate at a given level of oxygen consumption were higher for arm than for leg work during both submaximal and maximal exercise. It is concluded that arm ergometry offers an alternative testing method to leg testing in patients with moderate chronic obstructive lung disease.
Calcified right atrial mass: Report of a case and discussion of the differential diagnosis
Authors: H. A. Fleming, P. G. I. Stovin
Journal: Thorax (1972)

This is the report of a case of a grossly calcified right atrial mass in a woman of 40 who also suffered from systemic hypertension, pyelonephritis, and hepatic cirrhosis. The differential diagnosis, surgical treatment, and necropsy findings are described along with a review of the literature.
Association of primary sclerosing cholangitis and celiac disease: Fact or fancy?
Authors: Erik Schrumpf
Journal: Hepatology (1989)

The association of primary sclerosing cholangitis and celiac disease was observed in three patients, an association not previously reported. All three patients were men who presented with chronic cholestatic liver disease at ages 32, 46, and 62 years, respectively. In each patient, endoscopic retrograde cholangiography showed the typical findings of primary sclerosing cholangitis. Histologic features of liver biopsy were compatible with the diagnosis. Two patients had associated chronic ulcerative colitis. All three patients complained of frequent loose stools and weight loss; subsequent testing showed severe steatorrhea (204 to 323 mmolfd of fecal fat on a 100 g fat diet). Total villous atrophy was found in all three patients on histologic examination of the small bowel. Celiac disease was diagnosed at the time of presentation in two patients who had primary sclerosing cholangitis and was diagnosed three years after the onset of primary sclerosing cholangitis in the third patient. The celiac disease responded to a gluten–free diet in each patient whereas the primary sclerosing cholangitis was not affected by dietary treatment. The possibility of a chance association of primary sclerosing cholangitis and celiac disease cannot be accurately assessed but seems unlikely given the rarity of both diseases. The relationship between the two diseases remains unknown, although an immunologic connection is suspected. Celiac disease should be considered in the differential diagnosis of severe steatorrhea in patients with primary sclerosing cholangitis.
RABBIT MACROPHAGE INTERFERONS
Authors: Thomas J. Smith, Robert R. Wagner
Journal: The Journal of Experimental Medicine (1967)

Antiviral factors present in cultures of rabbit peritoneal macrophages or rabbit kidney (RK) cells infected with Newcastle disease virus (NDV) and those in cultures of uninfected macrophages all fulfilled the biological and physicochemical criteria for classification as interferons. Virus-induced macrophage and RK interferons were slightly more stable to heat or acid than "spontaneously produced" or endotoxin-induced macrophage interferon. Interferon activity in serum of NDV-infected rabbits was decidedly more labile than NDV-induced macrophage interferon. However, these differences in lability were too slight to serve as a useful basis for distinguishing one rabbit interferon from another. Rabbit interferons from various sources could be differentiated by filtration through Sephadex G-100 and their molecular weights estimated by comparison with elution profiles of a series of marker proteins of known molecular weight. Each of four different preparations of rabbit interferons was found to contain more than one molecular component. Elution peaks for three NDV-induced interferons were equivalent to the following molecular weights: RK approximately 44,000-45,000 and > 134,000 (variable and < 1% when present); macrophage approximately 37,000, 44,000-45,000, and > 134,000 (variable and <1% when present); and serum approximately 50,000-52,000 and > 134,000 ( approximately 10% and heat labile). NDV-induced serum interferon may also contain another molecular component of mol wt approximately 45,000 represented by a trailing shoulder from the major 51,000 mol wt peak. Endotoxin-induced macrophage interferon proved to be polydisperse. Sephadex filtration of this interferon did not reveal clear and consistent elution patterns, partially owing to its low initial titer and lability. However, variable peaks of biological activity could be detected in Sephadex fractions equivalent to approximate molecular weight values of > 134,000, 72,000-78,000, 33,000-38,000, 28,000-30,000, and possibly a component of 42,000-45,000. A major component of mol wt approximately 37,000 was present in all samples of endotoxin-induced macrophage interferon. The other constituents may be biologically active subunits or polymers. These data indicate that rabbit macrophages produce two primary kinds of interferon: (a) an RK-like component of mol wt approximately 45,000 that is synthesized in greatest amount after viral induction, and (b) a different species of mol wt approximately 37,000 that can also be synthesized in the absence of viral induction. The presence of major interferon constituents of mol wt approximately 51,000 and > 134,000 in rabbit serum after viral induction suggests that macrophages are not the principal interferon-producing cells that respond to intravenous injection of NDV.
A case of acute eosinophilic pneumonia caused by inhalation of Trichosporon terrestre.
Authors: E Miyazaki, K Sugisaki, T Shigenaga, T Matsumoto, S Kita, Y Inobe, T Tsuda
Journal: American Journal of Respiratory and Critical Care Medicine (1995)

We present the diagnostically challenging case of an 18-yr-old Japanese woman who presented with fever, nonproductive cough, and acute respiratory distress. Her chest radiograph showed diffuse interstitial infiltrates and bilateral pleural effusions. Eosinophilic pneumonia was diagnosed by bronchoalveolar lavage and transbronchial lung biopsy. She was treated with minocycline, and was discharged in 2 wk. However, within 3 h of returning home, she experienced a recurrence. She showed positive immediate, Arthus, and delayed-type skin reactions and positive lymphocyte stimulation test to an antigen derived from Trichosporon terrestre, which was isolated from dust in her home. In addition, a bronchoprovocation test with the same antigen caused a nonproductive cough with fever, hypoxemia, and peripheral eosinophilia. We concluded that T. terrestre was the causal agent of the acute eosinophilic pneumonia.
HDACs and Hypertrophy, Kinases and Cancer
Authors: Berdymammet Hojayev, Joseph A. Hill
Journal: Circulation (2011)

I n the course of daily life, the heart reacts to alterations in workload demand with changes in contractility and beating rate; over time, robust changes in ventricular volume and mass take place. 1 In the context of organism development, athleticism, or pregnancy, the cardiac growth response is normal and adaptive.In the context of pathological triggers, however, cardiac remodeling is ultimately maladaptive and a discrete milestone in disease pathogenesis.The end result is heart failure, a syndrome with Ϸ50% 5-year mortality, rivaling the most lethal cancers.
ONLY TOTAL OCCLUSION TYPE IN-STENT RESTENOSIS IS ASSOCIATED WITH POOR FUNCTIONAL AND CLINICAL OUTCOMES AFTER SUCCESSFUL PRIMARY PERCUTANEOUS CORONARY INTERVENTION FOR ST ELEVATION MYOCARDIAL INFARCTION
Authors: Hiroyuki Shibata, Shinichiro Yamada, Takatoshi Hayashi, Yasuyo Taniguchi, Sachiyo Iwata, Katsunori Okajima, Akira Shimane, Tomofumi Takaya, Gaku Kanda, Naoki Miyoshi, Kiminobu Yokoi, Yukio Mizuguchi, Syogo Ohishi, Keiko Yodoi, Takayoshi Toba, Teishi Kajiya
Journal: Journal of the American College of Cardiology (2011)
Interval and continuous training are similarly effective in chronic obstructive pulmonary disease
Authors: Mark R Elkins, Tiffany J Dwyer
Journal: British Journal of Sports Medicine (2011)

1. Beauchamp MK, 2. Nonoyama M, 3. Goldstein RS, 4. et al . Thorax, 2010;65:157–64. [OpenUrl][1][Abstract/FREE Full Text][2] People with chronic obstructive pulmonary disease (COPD) experience progressive airflow limitation and are predisposed to respiratory infections, both of which can limit their exercise capacity, and quality and length of life. People with COPD benefit from pulmonary rehabilitation, which involves exercise training, education and psychosocial support. Exercise training does not improve lung function but instead reverses deconditioning and maximises the available exercise capacity to reduce the impact of COPD. Increasing the intensity of training results in greater gains in exercise capacity, but many people with COPD are unable to sustain high-intensity training. An alternative to continuous exercise is interval training, which involves periods of high-intensity exercise separated by recovery periods. Interval training may provide a tolerable training regimen with a greater overall training load than continuous exercise. This systematic review by Beauchamp and colleagues aimed to synthesise the best available evidence comparing the effectiveness of continuous and interval exercise training on exercise capacity and health-related quality of life in people with COPD. Six key biomedical databases were searched for appropriate studies published up until May 2009. The reference lists of identified studies were hand-searched. Only randomised trials of continuous versus interval exercise training on a cycle ergometer or treadmill were included. Participants had to have a clinical diagnosis of COPD, with impairment of either the forced expiratory volume in one second (FEV … [1]: {openurl}?query=rft.jtitle%253DThorax%26rft_id%253Dinfo%253Adoi%252F10.1136%252Fthx.2009.123000%26rft_id%253Dinfo%253Apmid%252F19996334%26rft.genre%253Darticle%26rft_val_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Ajournal%26ctx_ver%253DZ39.88-2004%26url_ver%253DZ39.88-2004%26url_ctx_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Actx [2]: /lookup/ijlink?linkType=ABST&journalCode=thoraxjnl&resid=65/2/157&atom=%2Fbjsports%2F45%2F2%2F155.atom
Clinical Biochemistry of Domestic Animals
Authors: R. E. Olsen
Journal: JAMA (1964)

For the teacher in veterinary clinical medicine or clinical pathology, this book is a most welcome addition to his armamentarium of teaching aids. It will help bridge the gap between basic and clinical sciences for the student in veterinary medicine. In addition, it should prove of value to the veterinary clinician in the interpretation of laboratory test results, as well as being a source of comparative biochemistry for the research worker in biology. There are 13 chapters devoted to organ function, plasma protein, fluids of the body cavities, porphyrins, uses of isotopes in veterinary clinical medicine, fluids and electrolytes, and disorders of carbohydrate, lipid, and mineral metabolism. There has been some attempt in each chapter to include sections reviewing biochemistry and discussing special tests, factors affecting interpretation of biochemical findings, and comparative normal and abnormal values. Certain chapters, such as that devoted to the use of radioisotopes in veterinary medicine,
Hypomagnesemia with secondary hypocalcemia is caused by mutations in TRPM6, a new member of the TRPM gene family
Authors: Karl P. Schlingmann, Stefanie Weber, Melanie Peters, Lene Niemann Nejsum, Helga Vitzthum, Karin Klingel, Markus Kratz, Elie Haddad, Ellinor Ristoff, Dganit Dinour, Maria Syrrou, Søren Nielsen, Martin Sassen, Siegfried Waldegger, Hannsjörg W. Seyberth, Martin Konrad
Journal: Nature Genetics (2002)