CRYOGLOBULINEMIA: REPORT OF A CASE ASSOCIATED WITH GANGRENE OF THE DIGITS
Authors: J H HUTCHINSON, R A HOWELL
Journal: Annals of Internal Medicine (1953)

Case Reports1 August 1953CRYOGLOBULINEMIA: REPORT OF A CASE ASSOCIATED WITH GANGRENE OF THE DIGITSJAMES H. HUTCHINSON, M.D., ROY A. HOWELL, M.D.JAMES H. HUTCHINSON, M.D.Search for more papers by this author, ROY A. HOWELL, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-39-2-350 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptIn 1947 Lerner and Watson1 suggested the term "cryoglobulinemia" to describe the presence of a cold precipitable protein in the serum. Three years later Barr, Reader and Wheeler2 reviewed the literature and found eight cases in which significant amounts of cryoglobulin had been observed; to these they added two of their own. Three additional cases have recently been recorded.3, 4, 5In the case reported here, cold precipitable globulins were demonstrated in association with Raynaud's phenomena which progressed to gangrene and required multiple amputations. To our knowledge this is the first instance in which gangrene has been associated with cryoglobulinemia....Bibliography1. LernerWatson ABCJ: Studies of cryoglobulins. I. Unusual purpura associated with the presence of a high concentration of cryoglobulin (cold precipitable serum globulin), Am. J. M. Sc. 214: 410, 1947. CrossrefMedlineGoogle Scholar2. BarrReaderWheeler DPGCCH: Cryoglobulinemia. I. Report of two cases with discussion of clinical manifestations, incidence and significance, Ann. Int. Med. 32: 6, 1950. LinkGoogle Scholar3. Rorvik K: Cryoglobulinemia, Acta med. Scandinav. 137: 390, 1950. CrossrefMedlineGoogle Scholar4. LuceyLeighHochMarrackJohns HCEHJRRG: Study of a case of purpura associated with bone changes and formation of a gel in the serum on cooling, Brit. J. Exper. Path. 31: 380, 1950. MedlineGoogle Scholar5. BianchiGiampalmoMarmont VAA: Contributo alla conoscenza della gelificazione plasmatica a frigore e della plasmocitosi aleucemica con emogelificazione (gel-plasmocitomatosi), Minerva med. 2: 101, 1949. Google Scholar6. MuirheadMontgomeryGordon EEPOCE: Thromboembolic pulmonary vascular sclerosis: report of a case following pregnancy and of a case associated with cryoglobulinemia, Arch. Int. Med. 89: 41, 1952. CrossrefGoogle Scholar7. AllenBarkerHines EVWEA: Peripheral vascular disease, 1946, W. B. Saunders Co., Philadelphia, p. 195. Google Scholar8. BayrdHeck EDFJ: Multiple myeloma—a review of 83 proven cases, J. A. M. A. 133: 147, 1947. CrossrefMedlineGoogle Scholar9. MostLavietes HPH: Kala azar in American military personnel, Medicine 26: 221, 1947. CrossrefMedlineGoogle Scholar10. LernerBarnumWatson ABCPCJ: Studies of cryoglobulins. II. The spontaneous precipitation of protein from serum at 5° C. in various disease states, Am. J. M. Sc. 214: 416, 1947. CrossrefMedlineGoogle Scholar11. Forbes GB: Autohaemagglutination and Raynaud's phenomenon, Brit. M. J. 1: 598, 1947. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: *Received for publication January 2, 1953.From the Department of Internal Medicine, Washington University, School of Medicine, and the Unit I (Washington University) Medical Service, St. Louis City Hospital, St. Louis, Missouri. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byCerebral Ischemia in Patients With Hepatitis C Virus Infection and Mixed CryoglobulinemiaBilateral forefoot ischemia as a premonitory symptom of mixed cryoglobulinemiaDeafness in CryoglobulinemiaMixed cryoglobulinemia: Clinical aspects and long-term follow-up of 40 patientsEncephalopathy associated with cryoprecipitable Australia antigenBiologic and clinical significance of cryoglobulinsParaproteinämische HämoblastosenLupus ErythematosusNeurological Manifestations Associated with Cold Hemagglutinin Syndrome Report of Two CasesRetikulosenHemopoietic SystemCRYOPROTEINEMIA IN LEPROSYTissue hypoxia in surgical practiceRetinal Findings Associated with Serum HyperviscosityCirculatory Problems in DysproteinemiaMesothelioma associated with cryoglobulinemiaExperiments on the Mechanism of Precipitation of CryoglobulinsESSENTIAL CRYOGLOBULINAEMIA.Krankheiten der GefäßePlasma-Cell Myeloma"MYELOMA" SERUM ELECTROPHORETIC PATTERNS IN CONDITIONS OTHER THAN MYELOMATOSISDie Pathomorphologie der NierenausscheidungDysproteinemiaDie MakroglobulinämieCRYOGLOBULINAEMIAEssential cryoglobulinaemiaCryo- and macroglobulinemiaKryoglobulinämieMakromolekulare Kryoglobulin�mie 1 August 1953Volume 39, Issue 2Page: 350-357KeywordsChemical fractionationGlobulinsHospital medicineMedical servicesProteinsResearch laboratoriesSerum proteins Issue Published: 1 August 1953 PDF downloadLoading ...