tbuckley/cabot-search huggingface dataset:
Abstract 17514: Hydrogen Sulfide Levels and NRF2 Activity are Attenuated in the Setting of Critical Limb Ischemia (CLI)
Authors: Kazi N Islam, David J Polhemus, Erminia Donnarumma, Hiroyuki Otsuka, Shashi Bhushan, Jessica M Bradley, Giuseppe Cirino, Brewster P Luke, David J Lefer
Journal: Circulation (2014)

Background: Cystathionine γ-lyase (CSE), cystathionine β-synthase (CBS), and 3-mercaptopyruvate sulfurtransferase (3-MST) are enzymatic sources of hydrogen sulfide (H2S). Functions of H2S are mediated by several targets including ion channels and signaling proteins. Nuclear factor-erythriod 2-related factor 2 (NRF2) is responsible for the expression of antioxidant response element (ARE)-regulated genes and is known to be upregulated by H2S. We examined the levels of H2S producing enzymes, H2S, and NRF2 activation status in skeletal muscle obtained from CLI patients. Methods: Gastrocnemius tissues were attained post amputation from human CLI and aged-matched control patients. Tissue H2S levels were measured using gas chromatography methods coupled with sulfur chemiluminescence. RT-qPCR, immunoblot, and electrophoretic mobility shift assay (EMSA) were used to analyze respective gene expression, protein levels, and DNA binding activity, respectively. Results: We found mRNA and protein levels of CSE, CBS, and 3-MST were significantly decreased in skeletal muscle of CLI (~2 fold, p &lt; 0.05) patients as compared to control. H2S and sulfane sulfur levels were significantly decreased in skeletal muscle of CLI patients. We also observed significant reductions in NRF2 activation (2 fold, p &lt; 0.05) as well as antioxidant proteins, such as CuZn-superoxide dismutase (2 fold, p &lt; 0.05), catalase (2 fold, p &lt; 0.05), and glutathione peroxidase (2 fold, p &lt; 0.05) in skeletal muscle of CLI patients. Biomarkers of oxidative stress, such as malondialdehyde and protein carbonyl formation were significantly increased (2 fold, p &lt; 0.05) in skeletal muscle of CLI patients as compared to age-matched controls. Conclusions: The data demonstrate that H2S bioavailability and NRF2 activation are both attenuated in CLI tissues concomitant with significantly increased oxidative stress. Reductions in the activity of H2S producing enzymes may contribute to the pathogenesis of CLI.
Cardiovascular Care of the Elderly.
Authors: Toma Strasser
Journal: Annals of Internal Medicine (1988)

In recent years there has been a spate of books on the terminal care of patients with cancer, but Cancer pain focuses on the single symptom that may dominate the last days of the patient and yet can be alleviated in most cases by a rational approach to treatment.This book by 13 contributors is divided into four sections: basic aspects of cancer pain; assessment; treatment; terminal care.The two chapters by Kathleen Foley on assessment of pain and pain syndromes give clear and concise guidance in establishing an accurate diagnosis as the key to appropriate treat- ment.The core chapter of the book on drug therapy is based on the World Health Organization international consensus on cancer pain and is preceded by a valuable chapter on therapeutic strategy by Vittorio Ventafridda.The chapters on oncological, nerve blocking and neurosurgical modalities in pain relief will be of only academic interest to general practitioners but they indicate the spectrum of specialist treatment available for the 1-207o of patients whose pain is not controlled by drugs.The one striking omission in this book is any reference to diamorphine when considering the strong opioid analgesics.In- deed, the advice to give morphine subcutaneously is impractical because of the volume of drug required for many patients on high doses of morphine; for diamorphine the volumes required are smaller.With this exception, I would strongly recommend this book to general practitioners.
X-linked recessive ichthyosis in a girl: strategy for identifying the causal mechanism
Authors: C. Thauvin‐Robinet, D. Lambert, G. Vaillant, P. Caillier, A. Donzel, V. Cusin, F. Huet, J.‐R. Teyssier, F. Mugneret, L. Faivre
Journal: British Journal of Dermatology (2005)
Abstract P201: Rural/Urban Differences in the Prevalence of Stroke Risk Factors
Authors: Erica L Dawson, John Higginbotham, Dawn O Kleindorfer, Elsayed Z Soliman, Mary Cushman, Monika M Safford, Virginia J Howard, Brett M Kissela, Suzanne E Judd, George Howard
Journal: Circulation (2015)

Introduction: Despite previously reported higher stroke (and heart disease) mortality in rural areas, there are few data on the presence or magnitude of rural-urban disparities in the prevalence of stroke risk factors. Methods: Participants (n = 28,242) of the REasons for Geographic And Racial Differences in Stroke (REGARDS) study were categorized into the 6-level ordinal National Center for Health Statistics Urban-Rural Classification Scheme. The prevalence of 6 traditional risk factors (hypertension, diabetes, cigarette smoking, atrial fibrillation, left ventricular hypertrophy and heart disease) and estimated 10-year risk of stroke (indexed by the Framingham Stroke Risk Function score) was assessed across the rural-urban scale in models adjustment for demographic factors (age, race, sex, and state of residence) and after further adjustment for community-level socioeconomic status disadvantage. Results: Hypertension, diabetes and heart disease were all more prevalent in rural regions (p &lt; 0.05); with respective odds 1.25-times (95% CI: 1.11 - 1.42), 1.15-times (95% CI: 0.99 - 1.33), and 1.19-times (95% CI: 1.02 - 1.39) greater in the most rural as compared to the most urban regions (see Table). The estimated 10-year risk of stroke was also greater in rural areas; however, the estimated magnitude of increased stroke risk was relatively small. Adjustment for neighborhood-level socioeconomic status disadvantage attenuated some, but not all, of these relationships (for example, hypertension OR: 1.25 to 1.21, diabetes OR: 1.15 to 1.00, heart disease OR: 1.19 to 1.10). Discussion: These data suggest that while some of the increased stroke mortality in rural areas may be due to an increased burden of stroke risk factors in rural areas, the contribution of risk factors is quite inconsistent across the rural-urban spectrum. This association was attenuated by the adjustment for socioeconomic status, which suggests that some of the higher stroke risk in rural counties may be due to their lower level of socioeconomic status.
Anatomie des membres. Dissection—Anatomie topographique.
Authors: Charles Dujarier
Journal: JAMA (1925)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Endovascular Therapy for Acute Ischemic Stroke
Authors: Mark J. Alberts, Ty Shang, Alejandro Magadan
Journal: JAMA Neurology (2015)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Neurology HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Neurology journal
Recent advances: Consumer health informatics
Authors: G. Eysenbach
Journal: BMJ (2000)

Medical informatics has expanded rapidly over the past couple of years. After decades of development of information systems designed primarily for physicians and other healthcare managers and professionals, there is an increasing interest in reaching consumers and patients directly through computers and telecommunications systems. Consumer health informatics is the branch of medical informatics that analyses consumers' needs for information; studies and implements methods of making information accessible to consumers; and models and integrates consumers' preferences into medical information systems. Consumer informatics stands at the crossroads of other disciplines, such as nursing informatics, public health, health promotion, health education, library science, and communication science, and is perhaps the most challenging and rapidly expanding field in medical informatics; it is paving the way for health care in the information age.

This non-exhaustive review focuses on topics from the field of consumer health informatics because there has been a markedly increased interest in this field (additional information is available on the BMJ 's website). Medline was searched using the terms “consumer” and “informatics.” The proceedings of the American Medical Informatics Association's symposiums (1998 and 1999) and the proceedings of the ninth World Congress on Medical Informatics (Medinfo 1998) were hand searched. The AltaVista search engine was used to retrieve information from the internet, using the search string “+definition + consumer health informatics” to find unpublished reports.1–3

Medical informatics is “the field that concerns itself with the cognitive, information processing, and communication tasks of medical practice, education, and research.” 4 Until recently medical informatics focused on developing applications for health professionals: medical informaticians looked at medical practice mainly through the eyes of health professionals rather than through the eyes of patients. Ten years ago Greenes and Shortliffe wrote: “After many years of development of information systems to support the infrastructure of …
477. New Pyridinium Cationic Lipids for Gene Delivery Synthesized Via Pyrylium Salts
Authors: Sandra Vanderbyl, Neil MacDonald, Tom Stodola, Adele Telenius, Sandra Stewart, Harry C. Ledebur, Carl F. Perez
Journal: Molecular Therapy (2004)

The ACE System is a versatile, reliable system for genetically modifying cell therapies, generating transgenic animals, and engineering mammalian cells for high expression of a recombinant protein. Key components of the ACE System include an artificial chromosome (Platform ACE) encoding multiple (>50) DNA site-specific integration sites (acceptor sites); a targeting vector (ACE Targeting Vector) encoding both a Platform ACE-specific DNA donor site and the therapeutic gene of interest; and a proprietary DNA recombinase (ACE Integrase) that catalyzes the site-specific recombination of ACE Targeting Vectors onto the Platform ACE. ACEs are a promising means of genetically modifying and engineering cells for cell therapy, as they are stably maintained, autonomous, non-integrating, easily purified by flow cytometry (de Jong et al, 1999) and readily transfected into a variety of cell types, including human adult stem cells (deJong et al, 2001; Vanderbyl et al, 2001; Vanderbyl et al, Stem Cells in Press).
Structural Study for a Mural
Authors: M. Therese Southgate
Journal: JAMA (2004)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Risks and Benefits of Combined Maze Procedure for Atrial Fibrillation Associated With Organic Heart Disease11It was presented at the 43rd Annual Scientific Session, American College of Cardiology, Atlanta, Georgia, March 1994.
Authors: AKIRA T. KAWAGUCHI, YOSHIO KOSAKAI, YOSHIKADO SASAKO, KIYOYUKI EISHI, KIYOHARU NAKANO, YASUNARU KAWASHIMA
Journal: Journal of the American College of Cardiology (1996)
An MRI study of brain size in autism
Authors: J Piven, S Arndt, J Bailey, S Havercamp, N C Andreasen, P Palmer
Journal: American Journal of Psychiatry (1995)

This study was undertaken to obtain detailed measurements of the volume of the brain, using magnetic resonance imaging (MRI), in a carefully selected group of autistic subjects and comparison subjects.Twenty-two male autistic subjects and 20 male volunteer comparison subjects were examined with detailed (1.5-mm slices) MRI throughout the entire brain. Total brain, total brain tissue, and total lateral ventricle volumes were measured by using manual tracing and automated techniques.After height and performance IQ were controlled, autistic subjects had significantly greater total brain, total tissue, and total lateral ventricle volumes than comparison subjects.These findings suggest that male autistic subjects have enlarged brains and that enlargement is a result of both greater brain tissue volume and greater lateral ventricle volume.
Abstract P5-15-22: Evaluation of quality of life in patients with advanced and metastatic breast cancer proposed for palliative chemotherapy and best supportive care versus best supportive care
Authors: Anda-Natalia T Ciuhu, Gabriela I Rahnea Nita, Mihaela T Popescu, Roxana Andreea D Rahnea Nita
Journal: Cancer Research (2015)

Abstract Background: In Romania many patients neglect their symptoms and present to the doctor in advanced stages of cancer. In the case of patients with breast cancer who present with very advanced locoregional disease (ulcerated or hemorrhagic tumors) and symptomatic metastatic disease (visceral or skeletal pain, dyspnea), the choice between chemotherapy/hormonal therapy and best supportive care and only best supportive care became very difficult. Objective: Evaluation of quality of life in patients with advanced and metastatic breast cancer proposed for palliative chemotherapy and best supportive care versus best supportive care Materials and methods: In the last 6 month of the year 2013, 57 patients with advanced and metastatic breast cancer were randomized to either chemotherapy/hormonal therapy in addiction to best supportive care or to best supportive care. The patients were naive to chemotherapy, with performance status – ECOG between 2 and 3 and had symptomatic disease. The randomization of patients was made according to their choice. The performance status and the symptoms were evaluated at the baseline and, later, at each admission in the Oncology Palliative Care Department. Results: More patients in the chemotherapy group (92.68%, 38/41) had an improve quality of life compared to those in the best supportive care group (56.25 %, 9/16). The overall survival was longer in the chemotherapy group. Conclusions: The results show that chemotherapy/hormonal therapy improve the quality of life and overall survival in very advanced locoregional disease and symptomatic metastatic breast cancer. The number of patients who benefit from chemotherapy and best supportive care is higher versus patients who benefit only from best supportive care. Key words: chemotherapy/hormonal therapy, best supportive care, breast cancer. Citation Format: Anda-Natalia T Ciuhu, Gabriela I Rahnea Nita, Mihaela T Popescu, Roxana Andreea D Rahnea Nita. Evaluation of quality of life in patients with advanced and metastatic breast cancer proposed for palliative chemotherapy and best supportive care versus best supportive care [abstract]. In: Proceedings of the Thirty-Seventh Annual CTRC-AACR San Antonio Breast Cancer Symposium: 2014 Dec 9-13; San Antonio, TX. Philadelphia (PA): AACR; Cancer Res 2015;75(9 Suppl):Abstract nr P5-15-22.
Screening for Colorectal Cancer
Authors: Gabriel E Feldman, Colin W McCord, Mary T Bassett, Thomas R Frieden
Journal: JAMA (2003)

To the Editor: In their Scientific Review article, Drs Walsh and Terdiman concluded that screening for colorectal cancer is clinically effective. Like other authors, they also concluded that the optimal screening method remains uncertain. On behalf of the New York City Department of Health and Mental Hygiene, we recently established guidelines recommending colonoscopy as the preferred method of screening for colon cancer, with annual fecal occult blood tests (FOBTs) as an acceptable, although not optimal, alternative for patients unable or unwilling to undergo colonoscopy. Our reasoning was based on the capabilities of colonoscopy to visualize the entire colon and to prevent colon cancer by performing a polypectomy at the time of the screening examination, as well as the large capacity of and the high quality of medical institutions in New York City. Separately, we surveyed 41 primary care physician opinion leaders (24 internists, 10 family physicians, and 7 obstetriciangynecology physicians) cited as the “best doctors in New York” by New York Magazine. We asked each physician to choose a preferred method of colon cancer screening for patients aged 50 years or older, for their friends and family, and for themselves, from among the following screening options: endoscopic colonoscopy, flexible sigmoidoscopy, fecal occult blood testing (FOBT), FOBT in combination with flexible sigmoidoscopy, computed tomographic colography (virtual colonoscopy), or double contrast barium enema. Of these physicians, 36 (88%) recommended colonoscopy as the preferred screening alternative for friends and family. The FOBT was preferred by 3 (7%), flexible sigmoidoscopy by 1 (2%), and the combination of FOBT and flexible sigmoidoscopy was preferred by 1 (2%). Thirty-five respondents (85%) preferred colonoscopy for themselves. This survey suggests that many clinician opinion leaders, at least those in New York City, recommend colonoscopy as their colorectal cancer screening method of choice. We estimate our citywide colonoscopy capacity at approximately 150000 annually (New York City Department of Health and Mental Hygiene, unpublished data), which is sufficient to meet the demand for colonoscopy screening every 10 years for residents aged 50 years to 75 years. Reimbursement issues and safety monitoring will be important components of any effort to provide colonoscopy screening to the entire population at risk.
A CASE OF DIAPHRAGMATIC HERNIA IN WHICH MARKED CYANOSIS AND DYSPNEA WERE THE PRE-DOMINATING SYMPTOMS
Authors: Henry F. Stoll
Journal: Annals of Internal Medicine (1936)

Case Reports1 September 1936A CASE OF DIAPHRAGMATIC HERNIA IN WHICH MARKED CYANOSIS AND DYSPNEA WERE THE PRE-DOMINATING SYMPTOMSHENRY F. STOLL, M.D., F.A.C.P.HENRY F. STOLL, M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-10-3-395 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptIt is of more value to the clinician to be acquainted with the varied clinical pictures which may be caused by a diaphragmatic hernia than to be fully informed as to the details of its anatomical features, or as to the various proposed classifications of diaphragmatic defects. In the instance to be reported, the presenting symptoms and signs were unusually misleading; and it is from this point of view that the case seems worthy of record.E. V., female, aged 50 years, was admitted to the Hartford Hospital on May 9, 1935, and died on May 10, 1935.Chief Complaint:... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: HENRY F. STOLL, M.D., F.A.C.P.Affiliations: Hartford, Connecticut*Received for publication November 13, 1935. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byZwerchfellZwerchfellhernien und -prolapseTHORACIC STOMACH SIMULATING LEFT VENTRICULAR FAILURE*HENRY H. HAFT, M.D., F.A.C.P., DANIEL K. ADLER, M.D.Diaphragmatic hernia 1 September 1936Volume 10, Issue 3Page: 395-399KeywordsDyspneaHerniaSigns and symptoms ePublished: 1 December 2008 Issue Published: 1 September 1936 PDF downloadLoading ...
Anti-tumor activity in vitro and in vivo from DNA damage induced by QS-ZYX-1-61
Authors: Mei-Chuan Chen, Shiow-Lin Pan, Jih-Hwa Guh, Kuo-Hsiung Lee, Che-Ming Teng
Journal: Clinical Cancer Research (2007)

AACR Centennial Conference: Translational Cancer Medicine-- Nov 4-8, 2007; Singapore

B43 

Agents that cause DNA damage have been widely used as anticancer drugs for decades. The DNA lesions can make DNA checkpoints initiation and induce cell death. In recent years, there are many clinical trials were designed in combination with many DNA damage agents which trigger apoptosis through different mechanisms. The compound QS-ZYX-1-61 is a new DNA damage drug which GI50 value of 0.02 μM in A549 human lung carcinoma cells using SRB assay. We found that treatment with QS-ZYX-1-61 results in a dramatic increase of apoptosis with caspase- 3/8/9 activation and survivin down-regulation using Western blot analysis. In addition, the increased expressions of p53, p21, and Bcl-2 family member puma, indicated the cell cycle arrest at G1/S phase after the cells had been treated with QS-ZYX-1-61. However, both the ataxia telangiectasia mutated (ATM)/checkpoint kinase (Chk) 2 and ATM- and Rad 3-related (ATR)/Chk1 checkpoint pathways are activated after treatment with DNA damage agents. In the present data indicate that exposure to QS-ZYX-1-61 may lead to ATM and chk2 activation, with the downstream consequences related to the arrest in cell cycle progression to undergo apoptosis. In a corollary in vivo study, QS-ZYX-1-61 significantly inhibition of tumor growth in SCID mice inoculated with A549 cells. Taken together, our results indicate that QS-ZYX-1-61 induces cell cycle arrest and inhibits tumor growth in vitro and in vivo via the activation of DNA damage checkpoints in A549 cells. Base on these results, QS-ZYX-1-61 is a potential antitumor agent worthy of further investigation.