THE FRACTIONATION OF IMPORTANT CONSTITUENTS OF GASTRIC JUICE OTHER THAN HYDROCHLORIC ACID
Authors: R CAPUTTO, V RICHMOND, L RUSSELL, S WOLF
Journal: Annals of Internal Medicine (1956)

Article1 November 1956THE FRACTIONATION OF IMPORTANT CONSTITUENTS OF GASTRIC JUICE OTHER THAN HYDROCHLORIC ACIDSTEWART WOLF, M.D., F.A.C.P., RANWEL CAPUTTO, M.D., VIRGINIA RICHMOND, M.S., LOIS RUSSELL, B.S.STEWART WOLF, M.D., F.A.C.P.Search for more papers by this author, RANWEL CAPUTTO, M.D.Search for more papers by this author, VIRGINIA RICHMOND, M.S.Search for more papers by this author, LOIS RUSSELL, B.S.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-45-5-825 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe present communication is a very preliminary report, essentially a statement of progress on an attempt to sort out the biologically important ingredients of the gastric juice.The importance of the stomach in the bodily economy was recognized in the early eighteenth century when the wealthy and indefatigable French scientist de Réaumur made his birds swallow tiny perforated metal containers in which he had placed particles of food.1Later he pulled up the containers and found that the food had been dissolved out of them. A few years later the brilliant Italian investigator, Abbé Spallanzani, first demonstrated that the solvent...Bibliography1. de Réaumur RA: Sur la digestion des oiseaux. Mémoire 1 and 2. Mém. de l'acad. roy. d. sc. 1752. Google Scholar2. Spallanzani L: Le Opere, 1932, Hoepli, Milan. Google Scholar3. Prout W: On the nature of the acid and saline matters usually existing in the stomachs of animals, J. de physiol. exper. Paris 4: 294-299, 1824. Google Scholar4. Beaumont W: Experiments and observations on the gastric juice and the physiology of digestion, 1833, F. P. Allen, Plattsburg. Google Scholar5. Schwann T: Über das Wesen des Verdauungsprozesses, Arch. f. Anat., Physiol. u. wissensch. Med. p. 90, 1836. Google Scholar6. Northrop JH: Crystalline enzymes; the chemistry of pepsin, trypsin and bacteriophage, 1939, Columbia University Press, New York. Google Scholar7. Castle WB: Observation on etiologic relationship of achylia gastrica to pernicious anemia, Am. J. M. Sc. 178: 748, 1929. CrossrefGoogle Scholar8. WolfWolff SHG: Human gastric function, an experimental study of a man and his stomach, 1943, Oxford University Press, New York. Google Scholar9. MackWolfStern MHSKG: Preliminary electrophoretic analysis of human gastric juice, J. Clin. Investigation 32: 862, 1953. CrossrefMedlineGoogle Scholar10. CaputtoSchultzKarnesWolf RPJS: Chromatographic analysis of fasting human gastric content, Federation Proc. 13: 22, 1954. Google Scholar11. RichmondCaputtoWolf VRS: Biochemical study of the large molecular constituents of gastric juice, Gastroenterology 29: 1017, 1955. CrossrefMedlineGoogle Scholar12. JohnsonRichmondCaputtoWolf PCVRS: Fractionation of human gastric content; the separation of intrinsic factor activity, abstract, J. Clin. Investigation 35: 716, 1956. Google Scholar13. GoettschPappenheimer MAM(a) : Nutritional muscular dystrophy in guinea pig and rabbits, J. Exper. Med. 54: 145, 1931. (b) Evans, H. M.: New light on the biological role of vitamin E, J. Mt. Sinai Hosp. 7: 65, 1940. CrossrefMedlineGoogle Scholar14. Pappenheimer AM: Certain nutritional disorders of laboratory animals due to vitamin deficiency, J. Mt. Sinai Hosp. 7: 65, 1940. Google Scholar15. MilhoratBartels ATEW: The defect in utilization of tocopherol in progressive muscular dystrophy, Science 101: 93, 1945. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: *Presented at the Annual Session of The American College of Physicians, Los Angeles, California, April 18, 1956.From the Department of Medicine, University of Oklahoma School of Medicine, and the Oklahoma Medical Research Foundation.†Aided by grants from the National Cancer Institute (USPHS), the Bureau of Medicine and Surgery, U. S. Army, and the Muscular Dystrophy Association of America.Requests for reprints should be addressed to Stewart Wolf, M.D., Professor of Medicine, University of Oklahoma School of Medicine, Oklahoma City, Oklahoma. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byTHE RECOGNITION AND ASSAY OF GASTRONEClinical Assessment of Gastric FunctionThe Significance of GastritisFractionation of the Biologically Active Large Molecular Components of Human Gastric Content 1 November 1956Volume 45, Issue 5Page: 825-830KeywordsBiologicsChemical fractionationFoodHydrochloric acidMuscular dystrophiesProteinsScientistsStomachSurgery ePublished: 1 December 2008 Issue Published: 1 November 1956 PDF downloadLoading ...