tbuckley/cabot-search huggingface dataset:
Renal carcinoma with thrombocytopenia, clubbing, and hypertrophic osteoarthropathy.
Authors: P T Wilmshurst, K R Mills, Y J Drabu
Journal: BMJ (1979)

agglutinating antibodies could be detected against the isolated strain, but by the time the enteritis was over the titre had risen to 1/1280.When we saw the patient in our outpatient clinic the titre had declined to 1/160.After the arthritis had disappeared no antibodies could be detected.Radiological examination of the sacroiliac and ankle joints showed no abnormalities.Tissue typing showed HLA-A 2,28; B 12,27.Eight weeks after the onset of the arthritis all signs and symptoms had disappeared.
Pathology and Laboratory Medicine
Authors: Cecilia M. Fenoglio-Preiser
Journal: JAMA (1993)

The explosion of knowledge and technology in cellular and molecular biology has universally affected medical research, clinical diagnosis, and treatment. The possibility of novel and innovative diagnostic approaches in all areas of the laboratory allows the pathologist to diagnose disorders with increasing accuracy, to predict populations at risk for the development of specific diseases, and to provide clinicians with an array of prognostic markers. No part of the laboratory is exempt from the influence of these technologies. In particular, the polymerase chain reaction, which allows detection of molecular abnormalities in very small patient samples, exemplifies this powerful technology. Molecular biologic evaluation of patients with cancer is one arena profoundly influenced by the polymerase chain reaction technique, since genetic changes that are detectable may have diagnostic or prognostic significance. Since normal protooncogene and tumor suppressor gene functions are required to maintain orderly differentiation and proliferation pathways in cells, it is reasonable
Soft x-ray therapy for cutaneous basal cell and squamous cell carcinomas
Authors: Klaus-Werner Schulte, Andrea Lippold, Christine Auras, Gernot Bramkamp, Claudia Breitkopf, Heinz-Joachim Elsmann, Eva Maria Habenicht, Volker Jasnoch, Helga Müller-Pannes, Rainer Rupprecht, Ludwig Suter
Journal: Journal of the American Academy of Dermatology (2005)
A POSSIBLE DIFFERENTIAL SIGN BETWEEN CARDIAC DILATATION AND PERICARDITIS WITH EFFUSION
Authors: W. J. CALVERT
Journal: JAMA (1910)

In attempting to develop a differential sign I wish to acknowledge the dangers of generalizing from my limited material and of interpreting post-mortem findings as clinical signs. While studying the details of the mechanics of the support of the normal and pathologic heart, some relations between the heart, right lung and liver turned my attention to the changes in the position of the liver due to dilatation of the right heart and to pericarditis with effusion. On analysis these changes seemed to be due to certain physical forces producing strains on given anatomic structures. As the nature and direction of these stresses are constant, varying only in degree, their effect should also be constant, varying only in degree. In the two lesions the physical forces present differ in that the support rendered the liver by the inferior cava through its connection with the heart and the connective tissue structures extending
THE IN VITRO DIFFERENTIATION OF MONONUCLEAR PHAGOCYTES
Authors: Zanvil A. Cohn, Belinda Benson
Journal: The Journal of Experimental Medicine (1965)

The influence of selected inhibitors of protein synthesis on the in vitro differentiation of mouse mononuclear phagocytes has been investigated. DL-p-Fluorophenylalanine at concentrations of 250 microg/ml inhibits the formation of three lysosomal hydrolases, cytochemically demonstrable acid phosphatase and osmiophilic, phase-dense granules. These effects occur in the absence of cell death and are reversed by L-phenylalanine. Puromycin at concentrations of 0.2 to 0.4 microg/ml has a similar effect on both the morphology and biochemistry of cell maturation. Colchicine at a concentration of 0.05 microg/ml inhibits the growth in cell diameter and has less of an effect on enzyme production. Cells exposed to leucine-H(3) for 2 to 3 minutes exhibit the localization of grains in the perinuclear-dense granule region. After an exposure of 60 minutes a similar localization is evident but with a correspondingly greater number of grains. A similar localization of grains occurs when choline-methyl-H(3) is employed as a tracer. The data suggest the storage of newly formed protein and possibly phospholipid in the centrosphere region.
Reduction in Size and Firmness of Breast
Authors: Roy C. Gumpel
Journal: JAMA (1963)

<h3>To the Editor:</h3> —The question concerning postpartum reduction in size and firmness of the breast (Questions and Answers,<i>JAMA</i><b>181</b>:724 [Feb 23] 1963) prompts me to share the following interesting example of the adage, "the unexpected always happens." In referring to the Chiari-Frommel syndrome, the consultant noted that treatment is, "unhappily, usually unsatisfactory." My treatment of a recent patient with that clinical complex proved unhappily, unusually satisfactory. An initial response to a course of radiation was short-lived, and subsequent surgical intervention demonstrated a cystic, chromophobe tumor. In keeping with the previously recognized trophic and target organ deficiencies and the radiation and operative treatments, replacement therapy with thyroid and cortisone was begun. Regret was expressed that a satisfactory hormone was not available to restore fertility. This disheartening news was received by the patient with no great dismay, perhaps because of the existing burden of family responsibility. Apparently freed of the
Chromosome Transfer Induced Aneuploidy Results in Complex Dysregulation of the Cellular Transcriptome in Immortalized and Cancer Cells
Authors: Madhvi B. Upender, Jens K. Habermann, Lisa M. McShane, Edward L. Korn, J. Carl Barrett, Michael J. Difilippantonio, Thomas Ried
Journal: Cancer Research (2004)

Abstract Chromosomal aneuploidies are observed in essentially all sporadic carcinomas. These aneuploidies result in tumor-specific patterns of genomic imbalances that are acquired early during tumorigenesis, continuously selected for and faithfully maintained in cancer cells. Although the paradigm of translocation induced oncogene activation in hematologic malignancies is firmly established, it is not known how genomic imbalances affect chromosome-specific gene expression patterns in particular and how chromosomal aneuploidy dysregulates the genetic equilibrium of cells in general. To model specific chromosomal aneuploidies in cancer cells and dissect the immediate consequences of genomic imbalances on the transcriptome, we generated artificial trisomies in a karyotypically stable diploid yet mismatch repair-deficient, colorectal cancer cell line and in telomerase immortalized, cytogenetically normal human breast epithelial cells using microcell-mediated chromosome transfer. The global consequences on gene expression levels were analyzed using cDNA arrays. Our results show that regardless of chromosome or cell type, chromosomal trisomies result in a significant increase in the average transcriptional activity of the trisomic chromosome. This increase affects the expression of numerous genes on other chromosomes as well. We therefore postulate that the genomic imbalances observed in cancer cells exert their effect through a complex pattern of transcriptional dysregulation.
Determining Prevalence of Chronic Kidney Disease Using Estimated Glomerular Filtration Rate
Authors: Pierre Delanaye, Etienne Cavalier, Jean Marie Krzesinski
Journal: JAMA (2008)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
THE ULTIMATE RESULTS OF THE BLOODLESS REPLACEMENTS OF CONGENITALLY DISLOCATED HIPS.
Authors: JOHN RIDLON
Journal: JAMA (1904)

<h3>CASES IN THE THIRD GROUP.</h3> The third group consists of the Lorenz cases, and is divided into three subgroups: (<i>a</i>), (<i>b</i>) and (<i>c</i>). He examined in my office and refused to operate on 17 patients, 27 hips, from 7 years (with 2½ inches shortening) to 29 years of age. He recommended operation in 3 other cases that, insofar as I can learn, have not been operated on. He advised operation in a unilateral case of 9 years, the operation to follow preliminary stretching by weight and pulley in bed for some weeks. This case I have since operated on, breaking the neck of the femur (Case 100, Group 4). He refused to operate on a unilateral case, a girl of 8 years, on the ground that replacement was impossible. This case was at once operated on by Dr. John L. Porter and myself, and appears as Case 98, Group 4.
Markedly improved outcomes and acceptable toxicity in adolescents and young adults with acute lymphoblastic leukemia following treatment with a pediatric protocol: a phase II study by the Japan Adult Leukemia Study Group
Authors: F Hayakawa, T Sakura, T Yujiri, E Kondo, K Fujimaki, O Sasaki, J Miyatake, H Handa, Y Ueda, Y Aoyama, S Takada, Y Tanaka, N Usui, S Miyawaki, S Suenobu, K Horibe, H Kiyoi, K Ohnishi, Y Miyazaki, S Ohtake, Y Kobayashi, K Matsuo, T Naoe
Journal: Blood Cancer Journal (2014)

The superiority of the pediatric protocol for adolescents with acute lymphoblastic leukemia (ALL) has already been demonstrated, however, its efficacy in young adults remains unclear. The ALL202-U protocol was conducted to examine the efficacy and feasibility of a pediatric protocol in adolescents and young adults (AYAs) with BCR-ABL-negative ALL. Patients aged 15-24 years (n=139) were treated with the same protocol used for pediatric B-ALL. The primary objective of this study was to assess the disease-free survival (DFS) rate and its secondary aims were to assess toxicity, the complete remission (CR) rate and the overall survival (OS) rate. The CR rate was 94%. The 5-year DFS and OS rates were 67% (95% confidence interval (CI) 58-75%) and 73% (95% CI 64-80%), respectively. Severe adverse events were observed at a frequency that was similar to or lower than that in children treated with the same protocol. Only insufficient maintenance therapy significantly worsened the DFS (hazard ratio 5.60, P<0.001). These results indicate that this protocol may be a feasible and highly effective treatment for AYA with BCR-ABL-negative ALL.
Ash1l controls quiescence and self-renewal potential in hematopoietic stem cells
Authors: Morgan Jones, Jennifer Chase, Michelle Brinkmeier, Jing Xu, Daniel N. Weinberg, Julien Schira, Ann Friedman, Sami Malek, Jolanta Grembecka, Tomasz Cierpicki, Yali Dou, Sally A. Camper, Ivan Maillard
Journal: Journal of Clinical Investigation (2015)

Rapidly cycling fetal and neonatal hematopoietic stem cells (HSCs) generate a pool of quiescent adult HSCs after establishing hematopoiesis in the bone marrow. We report an essential role for the trithorax group gene absent, small, or homeotic 1-like (Ash1l) at this developmental transition. Emergence and expansion of Ash1l-deficient fetal/neonatal HSCs were preserved; however, in young adult animals, HSCs were profoundly depleted. Ash1l-deficient adult HSCs had markedly decreased quiescence and reduced cyclin-dependent kinase inhibitor 1b/c (Cdkn1b/1c) expression and failed to establish long-term trilineage bone marrow hematopoiesis after transplantation to irradiated recipients. Wild-type HSCs could efficiently engraft when transferred to unirradiated, Ash1l-deficient recipients, indicating increased availability of functional HSC niches in these mice. Ash1l deficiency also decreased expression of multiple Hox genes in hematopoietic progenitors. Ash1l cooperated functionally with mixed-lineage leukemia 1 (Mll1), as combined loss of Ash1l and Mll1, but not isolated Ash1l or Mll1 deficiency, induced overt hematopoietic failure. Our results uncover a trithorax group gene network that controls quiescence, niche occupancy, and self-renewal potential in adult HSCs.
THE INFLUENCE OF ETHER ANESTHESIA, OF HEMORRHAGE, AND OF PLETHORA FROM TRANSFUSION ON THE PRESSOR EFFECT OF MINUTE QUANTITIES OF EPINEPHRINE
Authors: Peyton Rous, George W. Wilson
Journal: The Journal of Experimental Medicine (1919)

Ether anesthesia has a marked influence in diminishing the pressor response to minute amounts of epinephrine injected directly into the circulation. Hemorrhage also acts to lessen or abolish the response, and to a degree directly proportional to the lowering of the blood pressure it causes. In the exsanguinated animal an amount of epinephrine three or four times that sufficient to produce a pressure rise of 10 to 15 mm. of mercury under normal conditions, may be entirely without effect. The response to large doses, on the other hand, is uninfluenced by ether or hemorrhage. The facts stated have a practical bearing not only on the employment of epinephrine to tide over collapse but on its possible utilization in the future to raise a low blood pressure to the normal height and maintain it during a considerable period. For the amount of epinephrine which under normal conditions will suffice to bring up the blood pressure may have little or no effect on an etherized individual or on one who has lost blood. The same difficulty will doubtless be encountered under other conditions. In animals rendered plethoric by transfusion the response to small doses of epinephrine lessens in proportion as the blood pressure is increased by the plethora.
Lewis Bernard Cannell
Authors: J. Malpas
Journal: BMJ (2003)

Consultant radiologist Stoke Mandeville Hospital 1975-91 (b 1926; q St Mary's Hospital, London, 1958; MA, FRCR), died from heart disease on 19 March 2003.​2003.




Figure 1




After service in the Royal Air Force, Lewis read modern greats at Oxford. He played rugby for Oxford University, the Barbarians, and England, being capped on 19 occasions. He was considered by some to be the outstanding player of his generation. After qualifying in medicine, he did junior jobs in England and South Africa, eventually obtaining consultancies in radiology in Durban and later Johannesburg. In 1975 he returned to take up a consultant radiology post at Stoke Mandeville, where he pioneered the development of an ultrasound service and later computed tomography. He leaves a wife, Audrey.
Can Loss and Grief Activate Latent Neoplasia?
Authors: Massimo Biondi, Anna Costantini, Annamaria Parisi
Journal: Psychotherapy and Psychosomatics (1996)

Background. Nineteenth-century physicians working with cancer patients frequently reported that severe emotional losses and grief occurred in some cases before cancer. Research on psychoneuroimmunology seems to reactivate this interest and could give a possible convincing background. Method: We recently observed the case of a 45-year-old woman who developed symptoms of breast cancer (ductal infiltrating carcinoma, T1, N1, M0) 3 years after the loss of her only child. The affection for the child compensated inadequacies of her marriage, which became increasingly unstable. The child died in a dramatic accident at home, while his mother was near him but unable to help. Results: The patient had a moderate genetic-familial risk of mammary cancer. Animal studies strongly suggest that stress, through neuroimmunomodulatory mediatory mechanisms, can significantly affect appearance and progression of mammary cancer. The patient developed long-lasting intense grief, despair and hopelessness. Discussion: We discuss the case from three main standpoints: genetic and risk factors for breast cancer, findings which demonstrated a relationship between stress, neuroimmunomodulation and cancer in animals; data from autopsy studies which found foci of latent breast cancer in 20% of healthy women in the same age range. Stress does not create cancer. However we hypothesize that in this case it could have contributed by the activation of a latent neoplasia and/or by impairing immunosurveillance during a critical life phase.
Effects of inflammatory cytokines on vascular tone
Authors: F. Ohkawa, U. Ikeda, T. Kanbe, K. Kawasaki, K. Shimada
Journal: Cardiovascular Research (1995)

To assess the direct effects of the inflammatory cytokines interleukin-2 (IL-2), interleukin-6 (IL-6) and interleukin-8 (IL-8) on vascular smooth muscle contraction.Smooth muscle contractility was studied in the thoracic aorta isolated from male Sprague-Dawley rats. Syntheses of cAMP and nitric oxide (NO) were investigated in cultured rat vascular smooth muscle cells (VSMC).Pretreatment of the rings with IL-6 (10 ng/ml) for 180 min caused a significant inhibition of their contraction in response to 10(-5) M phenylephrine, wile Il-2 (10 ng/ml) and IL-8 (100 ng/ml) showed no significant effect on the contraction. The inhibitory effect of IL-6 exhibited a dose-dependency (0.1 approximately 10 ng/ml). In cultured rat VSMC, synthesis of cAMP was increased time-dependently by IL-6, while IL-2 and IL-8 failed to show any significant effects. IL-2, IL-6 and IL-8 did not affect the production of nitrite, a stable metabolite of NO, by VSMC.IL-6, but not IL-2 and IL-8, is a potent inhibitor of vascular contraction, which effect is mediated through the increased cAMP synthesis.
behavioral symmetry and reverse asymmetry in the chick and rat
Authors: victor h. denenberg
Journal: Behavioral and Brain Sciences (2005)

chicks reared in the absence of light and rat pups reared without extra stimulation fail to exhibit behavioral laterality, implying that a threshold amount of environmental stimulation is necessary for the brain to follow an asymmetry pathway. reverse asymmetry has been reported in the chick, but not the rat, though a sex difference resembling reverse asymmetry has been found in the rat.
Peer Review in Journals Indexed in Index Medicus
Authors: Lois Ann Colaianni
Journal: JAMA (1994)

To determine whether peer review policies are published in English-language journals indexed in Index Medicus and, secondarily, to obtain information on the peer review practices of such journals.Examined one issue of a sample of all journal titles written in English and indexed in Index Medicus, and all indexed English-language journals in four subject fields. A questionnaire was sent to the editors of journals in the subject fields requesting information on their peer review practices.Journals received at the National Library of Medicine.Editors of journals in four subject fields.Existence of a printed statement of the peer review process for manuscripts.Although the editors queried in the four subject fields indicated that overall, 56% to 65% of the articles were peer reviewed, clear statements about their peer review practices were not found in half of their journals or in the overall sample.Editors should publish clear statements of the peer review process followed for each type of article published in their journals.
Sharing the benefits of genetic research
Authors: Doris Schroeder, Miltos Ladikas, Udo Schuklenk, Carolina Lasén Lasén Diáz, Anita Kleinsmidt, Fatima Alvarez-Castillo,, Dafna Feinholz
Journal: BMJ (2005)

Thank you for your interest in spreading the word about The BMJ.NOTE: We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail. We do not capture any email address. Username * Your Email * Send To * You are going to email the following Sharing the benefits of genetic research Your Personal Message CAPTCHA This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
A Medical Humanist Says Good-bye
Authors: Celia Engel Bandman
Journal: JAMA (2008)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Effects of thyroid hormone (thyroxine) and testosterone on hepatic 11β-hydroxysteroid dehydrogenase mRNA and activity in pubertal hypothyroid male rats
Authors: Yan-Jun Liu, Yuichi Nakagawa, Kazuhiko Toya, Hirokazu Saegusa, Kaoru Nasuda, Akira Endoh, Takehiko Ohzeki
Journal: Metabolism (1998)
Manpower: compendium of deliberate mistakes
Authors: G Batchelor
Journal: BMJ (1986)

remains to be seen whether non-antisecretory doses of prostaglandins have any therapeutic effi- cacy in duodenal ulcer.The situation may be different for gastric ulcer, where a strong correlation between acid suppression and healing rates is not seen,4 or for maintenance therapy after ulcer healing, where a drug which enhances mucosal resistance and can prevent damage to normal mucosa might be of therapeutic benefit.It would be of considerable interest to study the effects of a non-antisecretory dose of a synthetic prostaglandin in gastric ulcer.