tbuckley/cabot-search huggingface dataset:
Absolute Proteome Composition and Dynamics during Dormancy and Resuscitation of Mycobacterium tuberculosis
Authors: Olga T. Schubert, Christina Ludwig, Maria Kogadeeva, Michael Zimmermann, George Rosenberger, Martin Gengenbacher, Ludovic C. Gillet, Ben C. Collins, Hannes L. Röst, Stefan H.E. Kaufmann, Uwe Sauer, Ruedi Aebersold
Journal: Cell Host & Microbe (2015)
Abstract 17569: Transapical Aortic Valve Implantation With the 2nd Generation Self-Expandable Symetis Acurate TA™ TAVI System - First Clinical Experience and 1-Year Follow-up Results
Authors: Susanne Pasa, Daniel Wendt, Philipp Kahlert, Karim El-Chilali, Fadi Al-Rashid, Polykarpos Patsalis, Mareike Eißmann, Raimund Erbel, Heinz Jakob, Matthias Thielmann
Journal: Circulation (2014)

Introduction: We report our first clinical experience and 1-year outcome of transapical transcatheter aortic valve implantation (TAVI) with the use of the 2nd generation self-expandable ACURATE TA™ device.

Methods: The Symetis (Symetis S.A., Ecublens, Switzerland) ACURATE TA™ system is composed of a porcine bioprosthesis attached into a self-expandable nitinol stent. This 2nd generation system enables anatomical orientation and facilitates intuitive implantation providing tactile feedback. Between 08/2010 and 06/2014 a total of 85 high-risk patients with symptomatic aortic stenosis were enrolled. All patients gave written informed consent. Clinical and hemodynamic data were prospectively recorded. Hemodynamic performance was evaluated by transthoracic echocardiography including mean pressure gradients (MPG) at baseline, discharge, 30-days, 6 and 12 months after surgery.

Results: Patients mean age was 79±7years (mean ±SD) and 55% were female. Logistic EuroSCORE was 32.6±10.7% and STS-score 6.8±3.0% on average. All but one valve could be implanted successfully. This single patient was converted to conventional surgery due to intra-procedural device embolization. Intra-procedural re-ballooning after deployment was performed in 28% of the patients. Mean aortic gradient was 43.6±19.3 mmHg preoperatively and significantly decreased to 13.0±6.6mmHg at 30 days postoperatively and remained stable with 10.3±5.8mmHg at 12 months. Thirty-day mortality was 2%. Survival was 89% at 6 and 12-months, and 78% at two and three years. During follow-up, three (3.5%) patients suffered from stroke and five (5.9%) patients required new pacemaker implantation. MPGs were 43.6±19.3mmHg at baseline, 12.5±7.0mmHg at discharge, 13.0±6.6mmHg at 30-days, 11.2±2.9mmHg at 6-months and 10.3±5.8mmHg at 12-months. At 30 days paravalvular regurgitation was ≤ mild in 95.3% and no patient had severe regurgitation. At 12 months follow-up all (100%) patients showed either none/trace or mild paravalvular leakage.

Conclusions: The present single-center study proves good hemodynamic performance with low paravalvular leakages and good clinical outcomes for transapical TAVI, using the ACURATE TA™ prosthesis over a 1 year follow-up period.
Antimicrobial Prophylaxis for Children with Vesicoureteral Reflux
Authors: Alejandro Hoberman, Saul P. Greenfield, Tej K. Mattoo, Ron Keren, Ranjiv Mathews, Hans G. Pohl, Bradley P. Kropp, Steven J. Skoog, Caleb P. Nelson, Marva Moxey-Mims, Russell W. Chesney, Myra A. Carpenter
Journal: New England Journal of Medicine (2014)

Children with febrile urinary tract infection commonly have vesicoureteral reflux. Because trial results have been limited and inconsistent, the use of antimicrobial prophylaxis to prevent recurrences in children with reflux remains controversial.
Abstract P338: Diurnal Salivary Cortisol is Associated with Increased Glycemia and Insulin Resistance: The Multiethnic Study of Atherosclerosis
Authors: Joshua J Joseph, Steven X Wang, Elias Spanakis, Ana Diez Roux, Teresa Seeman, Gary Wand, Belinda Needham, Sherita H Golden
Journal: Circulation (2015)

Introduction:  Hypercortisolism is associated with insulin resistance (IR) and diabetes mellitus (DM); however, to our knowledge prior studies have not examined the association of diurnal cortisol curve features with measures of glycemia or IR in a population-based setting. We hypothesized that cortisol curve features would be positively associated with (1) glycemia in those with and without DM and (2) IR, in non-diabetic subjects.   Methods:  We examined the cross-sectional association of cortisol curve features with glycemia and IR in 1,069 ethnically diverse men and women (mean age 70 ± 9) in the Multi-Ethnic Study of Atherosclerosis Stress II Study. Salivary cortisol measures were collected over 2 days with 8 time points measured per day. Cortisol curve features included log-transformed wake-up cortisol, cortisol awakening response (CAR; awakening to 30 minutes post-awakening), early decline slope (30 minutes to 2 hours post-awakening), late decline slope (2 hours post-awakening to bedtime), overall decline slope, bedtime cortisol, and total area under the curve (AUC). DM was defined based on fasting glucose (≥ 126 mg/dL), hypoglycemic medication use, and/or physician diagnosis. Glycemia was assessed via hemoglobin A1c (HbA1c) and IR via the homeostasis model assessment of IR (HOMA-IR). We used linear regression models to examine the cross-sectional association of log-transformed cortisol curve features with HbA1c, stratified by DM status, and with HOMA-IR in non-diabetic participants. Adjustments were made for socio-demographics, adiposity, depressive symptoms, medications and cigarette smoking.   Results:  The association of cortisol curve features with HbA1c varied by DM status in unadjusted and adjusted models. Following multivariable adjustment, cortisol curve features were not associated with HbA1c among non-diabetic subjects; however, among those with DM, early decline slope, overall decline slope, bedtime cortisol, and total cortisol AUC were significantly and positively associated with a 5.7% (95% CI, 2.3,9.3), 38.8% (95% CI, 4.4, 84.4), 3.1% (95% CI 1.1,5.2), and 5.3% (95% CI 2.3,8.5) higher HbA1c, respectively. Wake-up cortisol, CAR, and late decline slope were not associated with HbA1c. Among those without DM, wake-up cortisol and AUC were inversely associated with a 9.4% lower (95% CI, -14.3, -4.2) and 11% lower (95% CI, -17.2, -4.3) HOMA-IR, respectively, in the unadjusted model; however, these results were attenuated and became non-significant following multivariable adjustment (-1.6%; 95% CI, -6.4, 3.4 for wake-up cortisol and -2.8%; 95% CI, -9.2, 4.2 for AUC).   Conclusion:  Among those with DM, cortisol curve parameters suggestive of higher cortisol exposure were associated with higher HbA1c. These findings suggest a role for hypothalamic-pituitary-adrenal axis activation in hyperglycemia associated with DM.
Introduction to Physical Biochemistry
Authors: Henry B. Bull
Journal: JAMA (1941)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Long-Term Angiographic Follow-Up of Coronary Balloon Angioplasty in Patients With Diabetes Mellitus
Authors: Yoseph Rozenman, Dan Sapoznikov, Morris Mosseri, Dan Gilon, Chaim Lotan, Hisham Nassar, A.Teddy Weiss, Yonathan Hasin, Mervyn S Gotsman
Journal: Journal of the American College of Cardiology (1997)
PROBLEMS OF ENDEMIC GOITER
Authors: Friedrich Von Mueller
Journal: Annals of Internal Medicine (1937)

Article1 May 1937PROBLEMS OF ENDEMIC GOITERFRIEDRICH VON MUELLERFRIEDRICH VON MUELLERSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-10-11-1617 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe two goiter conferences held at Berne in 1928 and 1933 revealed to the trained eyes of the participants the fact that in different countries, as, for example, in Munich, Berne, Vienna, Oslo and Utrecht, the clinical course and microscopic appearance of endemic goiter are quite variable. One dare not, for example, carry over and apply the experience of McCarrison or the Scandinavian countries to the endemic malady of the subalpine regions or, perhaps, the North American areas. The fundamental studies of the Swiss investigators and recently those of Dieterle and Eugster have shown that endemic goiter is locally confined... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Munich*Received for publication March 10, 1937. Nextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byKrankheiten der SchilddrüseDisorders of internal gland secretion in children 1 May 1937Volume 10, Issue 11Page: 1617-1620 Issue Published: 1 May 1937 Copyright & PermissionsCopyright, 1937, by The American College of PhysiciansPDF downloadLoading ...
A systematic approach to evaluate humoral and cellular immune responses to Coxiella burnetii immunoreactive antigens
Authors: C. Chen, T.J. Bouman, P.A. Beare, K. Mertens, G.Q. Zhang, K.E. Russell-Lodrigue, J.P. Hogaboam, B. Peters, P.L. Felgner, W.C. Brown, R.A. Heinzen, L.R. Hendrix, J.E. Samuel
Journal: Clinical Microbiology and Infection (2009)
Abstract MP04: Determinants of attaining and maintaining a low cardiovascular risk profile - the Doetinchem Cohort Study
Authors: Gerben Hulsegge, Martha L Daviglus, Yvonne T van der Schouw, Henriëtte A Smit, W M Verschuren
Journal: Circulation (2014)

Introduction: Increasing the proportion of adults who attain and maintain low cardiovascular risk profile is essential in the prevention of cardiovascular disease (CVD). It is unknown which factors are associated with attaining and maintaining a low risk profile. We investigate the association of 6 demographic, 4 lifestyle, 3 CVD history, and 4 psychosocial determinants with 1) attaining and 2) maintaining a low risk profile. Method: CVD risk factors and determinants were measured at baseline (1987-1991) and 5-year intervals until 2013 among 6,390 adults initially aged 20-59. Participants were categorized into low risk (i.e., ideal levels of blood pressure, cholesterol, and body mass index, not smoking and no diabetes) and medium or high risk profile. Those with low risk profile maintained or lost their low risk status, whereas those with medium/high risk profiles maintained that risk profile or attained a low risk profile during 5 years follow-up. Determinants of change in risk profiles were examined using modified Poisson regression to obtain risk ratios (RR) and 95% confidence intervals (95%CI) and generalized estimating equations to combine multiple 5-year comparisons. Results: A small proportion of participants (3%) with medium/high risk profile attained a low risk profile during the following 5 years. Compared to those who maintained a medium/high risk profile, one unit increment in Mediterranean (healthy) diet score was associated with 9% (RR: 1.09, 95%CI: 1.02-1.16) and being physically active compared to being inactive with a 104% (RR: 2.04, 95%CI: 1.05-4.00) higher likelihood to attain a low risk profile. Older age (RR: 0.66), male gender (RR: 0.46), low (RR: 0.55) and intermediate (RR: 0.77) education, low education of partner (RR: 0.70), and being a homemaker (RR: 0.73) were significantly associated with lower chance to attain low risk status. Of those having a low risk profile, 40% maintained that low risk profile over 5 years. For those with low risk profile, only older age (RR: 0.93) and low educational level (RR: 0.80) were significantly inversely associated with maintaining low risk profile. Conclusion: Low education level had an unfavorable impact on changes in risk profiles. This underscores the need to target preventive efforts at individuals with low education in the prevention of CVD. A healthy diet and physical activity were the only modifiable risk factors that were favorably associated with attaining low risk profile.
Abstract P449: Use of Low-dose Aspirin as Secondary Prevention of Recurrent Ischemic Vascular Disease among Adults in the United States-- National Health Interview Survey, 2012
Authors: Jing Fang, Mary George, Carma Ayala, Yuling Hong, Fleetwood Loustalot
Journal: Circulation (2014)

Background: Current guidelines recommend that adults with ischemic vascular disease take low-dose aspirin or other antiplatelet medications as secondary prevention of recurrent cardiovascular events. The objective of this study is to assess the low-dose aspirin use among US adults with ischemic vascular disease. Methods: Using data from the 2012 National Health Interview Survey, we identified participants aged ≥40 years with ischemic vascular disease (self-reported history of myocardial infarction, stroke, coronary heart disease, or angina). Low-dose aspirin use was ascertained based on four questions: 1) ever advised to take low-dose aspirin; 2) among those who answered “yes”, they were also asked if they followed this advice; 3) for those who didn’t follow the advice, they were asked if they were later advised not to take low-dose aspirin and 4) among those who were not advised to take low-dose aspirin, they were asked if they took it on their own. Multivariable logistic regression models were used to determine the adjusted odds ratio of aspirin use, adjusting for sociodemographic characteristics, health insurance status, and cardiovascular risk factors. Results: In 2012, among those with ischemic vascular disease (N=3213), 76.2% (95% confidence interval 74.3-77.9) had been told to take low-dose aspirin, and 87.8% (86.0-89.5) followed this advice. Among those who were not advised to take low-dose aspirin, only 11.4% (8.7-14.8) were taking low-dose aspirin on their own. Among those who weren’t following the advice, 53.2% (45.5-60.9) were later told not to take low-dose aspirin. Overall, 69.6% (67.6-71.5) were taking low-dose aspirin. Logistic regression showed those ≥ 65 years were more likely to take low-dose aspirin than those aged 40-64 (adjusted odds ratio =1.50, 95% CI=1.17-1.93). Non-Hispanic blacks and Hispanics were less likely to take LDA compared to non-Hispanic whites (adjusted odds ratio =0.71, CI=0.54-0.94; adjusted odds ratio =0.54, 95% CI=0.38-0.77, respectively). Those with a high school education or with some college were less likely than those with ≥ college education to take low-dose aspirin (adjusted odds ratio =0.64, CI=0.46-0.90; adjusted odds ratio =0.66, CI=0.47-0.92, respectively). Men were more likely to take low-dose aspirin than women (adjusted odds ratio =1.39, CI=1.10-1.75). Conclusions: Among US adults with ischemic vascular disease, only 76% reported being advised to take low-dose aspirin, and 88% followed this advice. Of the 12% who did not follow this advice, half were later advised to not take low-dose aspirin. Participants reported good compliance with physician’s advice to take low-dose aspirin, yet there is room for improvement in providing advice for low-dose aspirin among those with ischemic vascular disease.
Aspirin‐Triggered Lipoxin Prevents Antiphospholipid Antibody Effects on Human Trophoblast Migration and Endothelial Cell Interactions
Authors: Angela M. Alvarez, Melissa J. Mulla, Lawrence W. Chamley, Angela P. Cadavid, Vikki M. Abrahams
Journal: Arthritis & Rheumatology (2014)

Antiphospholipid antibodies (aPL) interfere with several physiologic functions of human trophoblasts, including reducing their ability to migrate, decreasing their production of angiogenic factors, and inducing an inflammatory response. This may provide the underlying mechanism by which aPL responses lead to recurrent pregnancy loss or preeclampsia in women with obstetric antiphospholipid syndrome (APS). Although treatment with heparin may reduce the rate of recurrent pregnancy loss, the risk of preeclampsia remains high. Therefore, alternative treatments are needed for the management of pregnant patients with APS. Since aspirin-triggered lipoxins (ATLs) have immune and angiogenic modulatory properties, the objective of this study was to determine the effects of the ATL 15-epi-lipoxin A4 on the function of aPL-altered human trophoblasts in the first trimester of pregnancy.A first-trimester human trophoblast cell line (HTR8) was treated with mouse anti-human β2 -glycoprotein I monoclonal antibodies (aPL) in the presence or absence of the ATL 15-epi-lipoxin A4 . Trophoblast migration and interactions with endometrial endothelial cells were measured using Transwell and coculture assays. Trophoblast secretion of cytokines and angiogenic factors was measured by enzyme-linked immunosorbent assay.Treatment of HTR8 cells with ATL reversed the aPL-induced decrease in trophoblast migration, an effect that appeared to be regulated through restoration of interleukin-6 production. Using a model of spiral artery transformation, aPL and sera from APS patients with pregnancy morbidity disrupted trophoblast-endothelial cell interactions, and treatment with ATL restored the stability of the cocultures. In contrast, ATL treatment did not resolve the proinflammatory and antiangiogenic responses of trophoblasts induced by aPL.These findings indicate that ATLs may have some benefits in terms of preventing the effects of aPL on trophoblast function, which raises the possibility of the use of ATLs as an adjuvant therapy in women with aPL.
Prescription Opioid Duration of Action and the Risk of Unintentional Overdose
Authors: Xiulu Ruan, Jiang Wu, Alan David Kaye
Journal: JAMA Internal Medicine (2015)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Internal Medicine HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Internal Medicine journal
THE ASSOCIATION OF ATROPHIC GASTRITIS WITH HYPOTHYROIDISM; A PRELIMINARY REPORT OF 11 CASES
Authors: Frank C. Golding
Journal: Annals of Internal Medicine (1942)

Article1 November 1942THE ASSOCIATION OF ATROPHIC GASTRITIS WITH HYPOTHYROIDISM; A PRELIMINARY REPORT OF 11 CASESFRANK C. GOLDING, A.B., M.D.FRANK C. GOLDING, A.B., M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-17-5-828 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptIt is well recognized that anemia and hypochlorhydria or achlorhydria are frequently present in patients having hypothyroidism or myxedema.1 Gastroscopy has demonstrated that atrophy of the gastric mucosa is also frequently associated with anemia and hypochlorhydria or achlorhydria.2This frequent occurrence of anemia and hypochlorhydria or achlorhydria in both hypothyroidism and atrophic gastritis led me to believe that it would be worth while to study a series of hypothyroid or myxedematous patients to determine whether or not there is a significantly high percentage of gastric atrophy present in these conditions.Herein are reported a series of 11 cases of hypothyroidism...Bibliography1. MEANS JH: The thyroid and its diseases, 1937, J. B. Lippincott Co., Philadelphia, pp. 217, 218, 253. Google Scholar2. SCHINDLER R: Gastroscopy, 1937, University of Chicago Press, Chicago, pp. 202, 203, 204, 205, 206. Google Scholar3. BASSLER A: Three cases of masked hypothyroidism having abdominal symptoms, Endocrinology, 1940, xxvi, 218-220. CrossrefGoogle Scholar4. DU BOIS EF: Basal metabolism in health and disease, Third Edition, Lea and Febiger, Philadelphia, pp. 389, 390, 391. Google Scholar5. HERTOGHE E: Thyroid insufficiency, Practitioner, 1915, xciv, 28-36. Google Scholar6. MANSFIELD G: La glande thyroide et l'anemie pernicieuse, Presse méd., Paris, 1938, xlvi, 993, 994. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Denver, Colorado*Received for publication November 15, 1941.From the Department of Medicine, University of Colorado School of Medicine. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byHypogastrinemia in hypothyroidismEffect of endocrine glands on function of the gastrointestinal tractThe Gastric Mucosa in Diabetes MellitusPhysiology and treatment of myxedemaThe Relationship of Gastric Motility to Abdominal Pain in Hypothyroidism: A Preliminary Report 1 November 1942Volume 17, Issue 5Page: 828-834KeywordsAchlorhydriaAnemiaAtrophyGastric mucosaGastritisGastroenterology and hepatologyHypothyroidism ePublished: 1 December 2008 Issue Published: 1 November 1942 PDF downloadLoading ...
Re-evaluation of “reactive lymphoid hyperplasia of the uvea” 1 1The opinions and assertions contained herein are the private views of the authors and are not to be construed as the views of the Department of the Air Force, Department of the Army, or the Department of Defense.
Authors: Glenn C Cockerham, Ahmed A Hidayat, Karen E Bijwaard, Zong-Mei Sheng
Journal: Ophthalmology (2000)