THE RESPONSE OF ACUTE LEUKEMIA TO THE ADMINISTRATION OF THE FOLIC ACID ANTAGONISTS, AMINOPTERIN AND AMETHOPTERIN: REPORT OF 14 CASES
Authors: M S SACKS, G T BRADFORD, E B SCHOENBACH
Journal: Annals of Internal Medicine (1950)

Article1 January 1950THE RESPONSE OF ACUTE LEUKEMIA TO THE ADMINISTRATION OF THE FOLIC ACID ANTAGONISTS, AMINOPTERIN AND AMETHOPTERIN: REPORT OF 14 CASESMILTON S. SACKS, M.D., F.A.C.P., GEORGE T. BRADFORD, M.D., EMANUEL B. SCHOENBACH, M.D.MILTON S. SACKS, M.D., F.A.C.P.Search for more papers by this author, GEORGE T. BRADFORD, M.D.Search for more papers by this author, EMANUEL B. SCHOENBACH, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-32-1-80 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptINTRODUCTIONIn June 1948 Farber et al.1presented a preliminary report on the therapy of acute leukemia in children, with the folic acid antagonist, aminopterin, 4-amino pteroylglutamic acid (N-[4-{2,4 diamino-6-pteridyl)-methyl] amino} benzoyl] glutamic acid). Of a group of 16 cases treated, five were reported in some detail. The latter were believed to have experienced temporary remissions. In February, 1949 in a follow-up report,2the senior author stated that approximately 60 cases of acute leukemia in children had been treated with aminopterin and other folic acid antagonists. Fifty per cent of this group of cases were reported to have shown...Bibliography1. FarberDiamondMercerSylvesterWolff SLKRDRFJA: Temporary remissions in acute leukemia in children produced by the folic acid antagonist, Medicine 233: 787, 1948. CrossrefGoogle Scholar2. Farber S: Some observations on the effect of folic acid antagonists on acute leukemia and other forms of incurable cancer, Blood 4: 160-167, 1949. CrossrefMedlineGoogle Scholar3. Dameshek W: The use of folic acid antagonists in the treatment of acute and subacute leukemia, Blood 4: 168-171, 1949. CrossrefMedlineGoogle Scholar4. JacobsonLevinHolt WWCG: Observations on the treatment of acute leukemias with analogues of folic acid, Jr. Lab. and Clin. 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Med. 27: 382, 1947. LinkGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: *Received for publication June 25, 1949.From the Department of Medicine of the University of Maryland School of Medicine and the Department of Preventive Medicine, Johns Hopkins University School of Medicine.This work was aided in part by a grant from the American Cancer Society to the Department of Preventive Medicine, Johns Hopkins University School of Medicine.Aminopterin and a-methopterin were supplied through the courtesy of the Lederle Laboratories Division of the American Cyanamid Co., New York, N. Y.†Baltimore Rh Laboratory Fellow in Medicine.The authors wish to express their appreciation to the following physicians for their courtesy and assistance in studying the cases presented in this report: Drs. J. Edmund Bradley, Tobias Weinberg, Milton Sherry, Hugh R. Spencer, H. Raymond Peters, Alexander J. Schaffer. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byFolate AntagonistsSynthesis and Evaluation of Hydrogen Peroxide Sensitive Prodrugs of Methotrexate and Aminopterin for the Treatment of Rheumatoid ArthritisMethotrexateMethotrexatePancreatic Proteolytic Enzyme Therapy Compared With Gemcitabine-Based Chemotherapy for the Treatment of Pancreatic CancerTransport of Aminopterin by Human Organic Anion Transporters hOAT1 and hOAT3: Comparison with MethotrexateCase files of the New York City Poison Control Center: Antidotal strategies for the management of methotrexate toxicityPhase II Trial of Oral Aminopterin for Adults and Children with Refractory Acute LeukemiaTHE FOLIC ACID COMPLEXMULTIPLE REMISSIONS IN AN ADULT WITH ACUTE LEUKEMIA TREATED PRINCIPALLY WITH A-METHOPTERIN*ESTHER FINCHER HAYS, M.D., THOMAS C. SCANLAN, M.D., RALPH L. ENGLE JR., M.D.PediatricsObservations on the effects of the folic acid antagonists, aminopterin and amethopterin, in patients with advanced neoplasmsThe effects of the folic acid antagonists and 2,6-diaminopurine on neoplastic disease.With special reference to acute leukemiaStudies on the mechanism of action of chemotherapeutic agents in cancer.V. Influence of the citrovorum factor and folic acid on the toxic manifestations of aminopterin in mice 1 January 1950Volume 32, Issue 1Page: 80-115KeywordsAmino acidsCancer preventionChildrenFolic acidMethotrexatePreventive medicine ePublished: 1 December 2008 Issue Published: 1 January 1950 PDF downloadLoading ...