tbuckley/cabot-search huggingface dataset:
Interaction between KIR3DS1 and HLA-Bw4 predicts for progression-free survival after autologous stem cell transplantation in patients with multiple myeloma
Authors: Ian H. Gabriel, Ruhena Sergeant, Richard Szydlo, Jane F. Apperley, Hugues deLavallade, Abdullah Alsuliman, Ahmad Khoder, David Marin, Edward Kanfer, Nichola Cooper, John Davis, Donald MacDonald, Marco Bua, Letizia Foroni, Chrissy Giles, Dragana Milojkovic, Amin Rahemtulla, Katayoun Rezvani
Journal: Blood (2010)
A SKIN TEST FOR SUSCEPTIBILITY TO SCARLET FEVER
Authors: GEORGE F. DICK
Journal: JAMA (1924)

In 1923, we succeeded in producing experimental scarlet fever with an apparently pure culture of a hemolytic streptococcus isolated from a case of scarlet fever.<sup>1</sup>The Berkefeld V filtrate of this culture did not produce scarlet fever in a person who later developed the disease on inoculation with the unfiltered culture. In the series of inoculation experiments in which scarlet fever was produced, only two of the ten volunteers acquired the disease. These ten volunteers were young adults who said that they had not had scarlet fever. They were all inoculated with the same culture. The failure of some to acquire scarlet fever, while others developed it in a typical form, was probably due to a difference in susceptibility. Attempts to demonstrate immunity to scarlet fever by means of skin tests had previously been made. In 1916, we<sup>2</sup>described the reaction occurring in convalescent scarlet fever patients on
Dysphagia and retrosternal pain related to a round plastic foreign body impacted in the esophageal wall for over 20 years
Authors: K. Zinkiewicz, M. Majewski, M. Krawczyk, W. Zgodzinski, T. Skoczylas, G. Wallner
Journal: Endoscopy (2008)

A 25-year-old female was referred to our unit with chronic solid-food dysphagia and retrosternal pain. According to the patient, all symptoms had persisted with fluctuating intensity since she was 6 years old. Regardless of several examinations (e. g. esophageal fluoroscopy, patient was refusing esophagoscopy) undertaken throughout this period, a history of other diseases was negative. After admission to our unit, endoscopic evaluation of the esophagus revealed a relatively tough stricture located below the pharyngoesophageal junction surrounded by inflammatory infiltration. Additionaly, a foreign body impacted in the esophageal wall at the same level was visualized. Subsequently, the object was safely extracted with a flexible endoscope while the patient was under general anesthesia ([Fig. 1] and [2]). The impacted foreign body appeared to be a 2 cm, round, plastic toy that was popular in Poland in the 1980s, which the patient claims to have swallowed at the age of 4 years ([Fig. 3]). As a result she suffered from continuous vomiting for a few days, yet was free from further symptoms until she was 6 years old, when dysphagia and retrosternal pain occured for the first time. Because the extracted foreign body was impacted deeply inside the esophageal wall, only a minor part was visible yet no secondary injuries or complications were encountered. After the procedure, postoperative care included a 5-day hospital stay with total parenteral nutrition and oral intake withheld. Afterwards, a rapid resolution of all symptoms was observed. The subsequent 12-month follow-up period was uneventful.
The Head Rolling Phenomenon
Authors: Edwin Swillinger
Journal: Annals of Internal Medicine (1990)

ExcerptTo the Editor:During the past 30 years I have done between 300 and 400 complete physical examinations annually. In 69 of those patients receiving annual examinations, I have consistently observed a peculiar phenomenon which I call the head rolling phenomenon. During auscultation of the chest, the patient is seated with the head straight forward and the hands resting in the lap. At the end of a mildly deep inspiration through the open mouth, the patient will inadvertently or unknowingly roll the head from one side to the other with a slight upward thrusting of the chin. The motion is...
AN OPERATIVE TREATMENT FOR CORNS
Authors: WALTER I. GALLAND
Journal: JAMA (1933)

The treatment of the common corn, which is one of the most widespread of the minor ailments affecting the feet, has been almost entirely ignored by the medical profession, and most sufferers have been exclusively treated by practitioners of chiropody. The common treatment is the paring down of the hypertrophied epithelium or the application of various types of keratolytic pastes, plasters, collodium paints and protective pads. These remedies are at best palliative and frequently, in spite of the adoption of proper footwear, the corn persists and continues to cause not inconsiderable discomfort. The palliative treatment of corns is adequate in perhaps the greater number of cases, but occasionally the condition is intractable and renders the wearing of any type of shoe painfully uncomfortable. Indeed, the irritated corn, which compels the individual to hold the foot in a strained attitude in order to avoid the unpleasant friction with the shoe, may
Boundaries of Schizoaffective Disorder
Authors: Roman Kotov, Shirley H. Leong, Ramin Mojtabai, Ann C. Eckardt Erlanger, Laura J. Fochtmann, Eduardo Constantino, Gabrielle A. Carlson, Evelyn J. Bromet
Journal: JAMA Psychiatry (2013)

Established nosology identifies schizoaffective disorder as a distinct category with boundaries separating it from mood disorders with psychosis and from schizophrenia. Alternative models argue for a single boundary distinguishing mood disorders with psychosis from schizophrenia (kraepelinian dichotomy) or a continuous spectrum from affective to nonaffective psychosis.To identify natural boundaries within psychotic disorders by evaluating associations between symptom course and long-term outcome.The Suffolk County Mental Health Project cohort consists of first-admission patients with psychosis recruited from all inpatient units of Suffolk County, New York (72% response rate). In an inception cohort design, participants were monitored closely for 4 years after admission, and their symptom course was charted for 526 individuals; 10-year outcome was obtained for 413.Global Assessment of Functioning (GAF) and other consensus ratings of study psychiatrists.We used nonlinear modeling (locally weighted scatterplot smoothing and spline regression) to examine links between 4-year symptom variables (ratio of nonaffective psychosis to mood disturbance, duration of mania/hypomania, depression, and psychosis) and 10-year outcomes. Nonaffective psychosis ratio exhibited a sharp discontinuity-10 days or more of psychosis outside mood episodes predicted an 11-point decrement in GAF-consistent with the kraepelinian dichotomy. Duration of mania/hypomania showed 2 discontinuities demarcating 3 groups: mania absent, episodic mania, and chronic mania (manic/hypomanic >1 year). The episodic group had a better outcome compared with the mania absent and chronic mania groups (12-point and 8-point difference on GAF). Duration of depression and psychosis had linear associations with worse outcome.Our data support the kraepelinian dichotomy, although the study requires replication. A boundary between schizoaffective disorder and schizophrenia was not observed, which casts further doubt on schizoaffective diagnosis. Co-occurring schizophrenia and mood disorder may be better coded as separate diagnoses, an approach that could simplify diagnosis, improve its reliability, and align it with the natural taxonomy.
Philosophical Perspectives on Psychiatric Diagnostic Classification
Authors: Carl C. Bell
Journal: JAMA (1994)

<b>DSM-IV Casebook: A Learning Companion to the Diagnostic and Statistical Manual of Mental Disorders</b>, edited by Robert L. Spitzer, Miriam Gibbon, Andrew E. Skodol, Janet B. W. Williams, and Michael B. First, 4th ed, 576 pp, $40.50, ISBN 0-88048-674-0, Washington, DC, American Psychiatric Press Inc, 1994. <b>The Clinical Interview Using DSM-IV</b>, vol 1:<b>Fundamentals</b>, by Ekkehard Othmer and Sieglinde C. Othmer, 513 pp, $40.50, ISBN 0-88048-541-8, Washington, DC, American Psychiatric Press Inc, 1994. The editors of<i>Philosophical Perspectives on Psychiatric Diagnostic Classification</i>have achieved their goal of producing a text to be "an exploration of the conceptual foundations of psychiatric diagnosis and classification." The contributing authors reveal the tacit assumptions that shape the perspectives of nosology; reveal the scientific, administrative, and practical consequences of specific nosologies; clarify methodological approaches to psychiatric classification; and generate new ideas to stimulate research. With the chapters written by different authors from different viewpoints, the
Binding, attention, and exchanges
Authors: Gary S. Dell, Victor S. Ferreira, Kathryn Bock
Journal: Behavioral and Brain Sciences (1999)

Levelt, Roelofs &amp; Meyer present a comprehensive and sophisticated theory of lexical access in production, but we question its reliance on binding-by-checking as opposed to binding-by-timing and we discuss how the timing of retrieval events is a major factor in both correct and errorful production.
Merriam-Webster's Medical Office Handbook
Authors: Jane M. Orient
Journal: JAMA (1997)

Office Management This book trades on the name Merriam-Webster, and the best part (recommended for both transcriptionists and physicians) is the 155 pages on the English language: punctuation, grammar, frequently confused words, and abbreviations. However, the advice on medical office management is decidedly generic, dangerously incomplete, and diametrically opposed in its underlying principles to what is manifested in Noah Webster's dictionary. Helpful sections include a discussion of filing methods, record disposition, and scheduling systems. Sample reports will serve as useful guides for transcriptionists. The computer sections are marginal at best. While emphasizing the need for frequent backups, the book gives little information about the types of systems that are available. The discussion of computer security is restricted to reprinting the American Medial Association position, with no practical advice on implementation and no mention of the potential third-party abuse of personally identifiable data entered into a networked computer. However, there is
COMPARISON OF IN VIVO ECCENTRICITY AND SYMMETRY INDICES BETWEEN METALLIC STENTS AND BIORESORBABLE VASCULAR SCAFFOLDS: INSIGHTS FROM THE ABSORB AND SPIRIT TRIALS
Authors: Salvatore Brugaletta, Josep Gomez-Lara, Roberto Diletti, Vasim Farooq, Maria Radu, Robert-Jan van Geuns, Bernard de Bruyne, Dariuz Dudek, Leif Thuesen, Bernard Chevalier, Dougal McClean, Stephan Windecker, Robert Whitbourn, Cecile Dorange, Dong Li, Susan Veldhof, Yoshinobu Onuma, Nico Bruining, Hector M. Garcia-Garcia, John A. Ormiston, Patrick W. Serruys
Journal: Journal of the American College of Cardiology (2011)
Abstract A20: Molecular Detection of Prostate-Specific Membrane Antigen in Canine Prostate Carcinoma Cells
Authors: Lisa Y. Wu, Tiancheng Liu, Bernard Vanwie, William C. Davis, Clifford E. Berkman
Journal: Cancer Research (2012)

Abstract Apart from the man, the dog develops prostate cancer spontaneously. Although the diseases in both species have several clinical aspects in common, not much is known about the expression of markers in the canine prostate cancer due to the lack of study in canine prostate cancer research. Therefore, the vast majority of canine prostate cancers at the time of diagnosis are end-staged. Numerous prostate cancer cell lines have been developed, but few cell lines develop bone metastases and no cell lines have been reported to cause brain metastases except the Ace-1 and the Leo canine prostate cancer cell lines. Prostate-specific membrane antigen (PSMA), which is known as a prostate cancer biomarker in humans, its usefulness in canine specimens has not been examined fully in these cell lines. Although there has been a considerable effort toward the development of PSMA-targeted diagnostic and therapeutic technologies for dogs, methods for detecting circulating and invasive prostate tumor cells currently remain limited. Previously, we developed a prostate circulating tumor cell (PCTC) detection method by a fluorescent PSMA inhibitor. The focus of the study is to evaluate PSMA expression on the Ace-1 and Leo cell lines by fluorescent conjugated PSMA inhibitor in flow cytometry. It is expected that the results will enable the development of detecting PSMA expressing canine cells in circulation for prognosis and diagnosis of canine prostate cancer. Citation Format: Lisa Y. Wu, Tiancheng Liu, Bernard Vanwie, William C. Davis, Clifford E. Berkman. Molecular Detection of Prostate-Specific Membrane Antigen in Canine Prostate Carcinoma Cells [abstract]. In: Proceedings of the AACR Special Conference on Chemical Systems Biology: Assembling and Interrogating Computational Models of the Cancer Cell by Chemical Perturbations; 2012 Jun 27-30; Boston, MA. Philadelphia (PA): AACR; Cancer Res 2012;72(13 Suppl):Abstract nr A20.
Plight of the younger consultant
Authors: M. J Armstrong
Journal: BMJ (1976)

Apart from the community physicians in their various roles, most of the other staff were recruited from the hospital services, knew little if anything of community medicine, and did not want to know.Fitted carpets, new furniture, and potted plants became the order of the day for the new administrators, the trans- ferred ex-local authority staff usually being left with their faded lino and furniture dating back to the early days of health departments.Developments in much-needed spheres such as the speech therapy service were curtailed because of financial considerations, while almost daily one saw further deliveries of new furniture and carpets.A plethora of subcommittees, working parties, and other teams appeared, all holding up the possibility of positive action even when there were few financial implications."Consensus" became stagnation.Fortunately I was able to retire- not to be replaced because of the financial crisis.
Abstract P5-08-10: Upregulation of microRNA-181a promotes metastasis of breast cancer cells following chemotherapy
Authors: J Niu, Y Shi, Z-H Wu
Journal: Cancer Research (2013)

Abstract Recent studies indicated that genotoxic treatment may promote cancer cell invasion. Moreover, resistance to chemotherapy highly correlates with high metastatic potential in breast cancer patients. Nevertheless, the molecular mechanisms linking chemotherapeutic resistance to metastasis remain poorly understood. Here, we show that microRNA-181a (miR-181a) plays an important role in promoting chemodrug-induced breast cancer metastasis. Treatment with genotoxic drugs increases miR-181a expression in triple-negative breast cancer cells, which is dependent on NF-kB activation by DNA damaging agents. Genotoxic NF-κB activation upregulates IL-6 expression and secretion in breast cancer cells, which leads to STAT3 (signal transducer and activator of transcription 3) phosphorylation and activation. Activated STAT3 translocates onto miR-181a gene promoter region and enhances its transcription in response to genotoxic treatments. Interestingly, chemodrug treatment also induces epigenetic modifications, such as increased histone H3 Ser28 phosphorylation and decreased H3 Lys27 trimethylation, at miR-181a promoter region, which are also required for miR-181a up-regulation. In addition, we found overexpression of miR-181a in breast cancer cells significantly enhanced cell invasion and metastasis, while inhibiting miR-181a reduced cell aggressiveness upon genotoxic exposure. We further show that miR-181a directly suppresses the expression of ataxia telangiectasia mutated (ATM) in breast cancer cells, which plays a pivotal role in DNA damage response and cancer progression. Therefore, our findings support a critical role of DNA damage-induced miR-181a in promoting breast cancer metastasis following chemotherapeutic treatment. Further exploration of molecular mechanisms regulating miR-181a induction and miR-181a-driven aggressive behaviors of breast cancer cells in response to chemotherapy may reveal novel approaches to reduce metastasis and improve therapeutic response in breast cancers by targeting miRNAs. Citation Information: Cancer Res 2013;73(24 Suppl): Abstract nr P5-08-10.
The Genetic Basis of Human Cancer
Authors: Charles M. Rubin
Journal: Annals of Internal Medicine (1998)

Medical Writings1 November 1998The Genetic Basis of Human CancerCharles M. Rubin, MDCharles M. Rubin, MDUniversity of Chicago Pritzker School of Medicine, Chicago, IllinoisSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-129-9-199811010-00045 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail The Genetic Basis of Human Cancer; Vogelstein B, Kinzler KW; eds. 731 pages. New York: McGraw-Hill; 1998. $95.00. ISBN 0070675961. Order phone 800-262-4729.Field of medicine: Cancer biology, oncology, and genetics.Format: Hardcover book.Audience: Scientists in cancer research, medical and graduate students, oncologists, and geneticists.Purpose: To describe the role of genes in the development of cancer.Content: This text has 43 chapters grouped into four parts: basic concepts in cancer genetics, control of solid-growth tumors, familial cancer syndromes, and site-specific neoplasms. The first chapter serves as a primer in human genetics that can be used as a reference ... Author, Article, and Disclosure InformationAffiliations: University of Chicago Pritzker School of Medicine, Chicago, Illinois PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 November 1998Volume 129, Issue 9Page: 759KeywordsCancer geneticsForecastingGenetic diseasesGraduate medical educationHuman geneticsMetabolic disordersMolecular biologyMutationScientists Issue Published: 1 November 1998 Copyright & PermissionsCopyright © 1998 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
A SIMPLE HAEMOGLOBINIZED SALINE CULTURE MEDIUM: FOR THE GROWTH OF LEISHMANIA AND ALLIED PROTOZOA
Authors: R. Row
Journal: BMJ (1912)

fAEMOGLOBINIZEI 1 SALINE CULTUBE MEDIUM.[MEDwsLJOuaA I I 19 small intestine could be traced into the rectum at the pelvic brim, with no apparent trace of caecum or appendix.The abdominal wound was closed in layers, and united by primary union.The patient made an uneventful recovery and
The Faculty Advisor on Internship Selection
Authors: George X. Trimble
Journal: New England Journal of Medicine (1963)

WITH the increasing concern being displayed by medical educators in the merits of the internship the failure by some to ensure that senior medical students are properly advised concerning the selection of an internship is somewhat anomalous.My experience over the past several years, during which correspondence has been carried on personally with 850 applicants for internship, as well as with an additional 1200 inquiring about internship, has led to certain observations and conclusions. I thought that it would be worthwhile sharing these with medical educators everywhere, particularly those who have the responsibility of counseling medical students about internship selection. . . .
Bilateral amastia in a female with X‐linked hypohidrotic ectodermal dysplasia
Authors: F. Al Marzouqi, C. Michot, S. Dos Santos, J.‐P. Bonnefont, C. Bodemer, S. Hadj‐Rabia
Journal: British Journal of Dermatology (2014)

Funding sources: no external funding. Conflicts of interest: none declared. Dear Editor, Ectodermal dysplasia is a clinically and genetically heterogeneous condition characterized by abnormal development of two or more of the following ectodermal‐derived structures: hair, teeth, nails and sweat glands. Anomalies in other organs including mammary glands (nipple and breast) may also be observed.1 Hypohidrotic or anhidrotic ectodermal dysplasia (HED/EDA), the most common phenotype of ED, is characterized by a triad of signs comprising sparse hair (hypotrichosis), abnormal or missing teeth (hypodontia or anodontia) and inability to sweat (hypo or anhidrosis). The most frequent form of HED/EDA is the X‐linked form (XLHED; MIM #305100) resulting from mutations in the EDA1 gene, located on chromosome Xq12–q13.1, which encodes the ectoderm signalling molecule ectodysplasin (MIM #300451), a member of the tumour necrosis factor (TNF) family; and mutations in the EDA receptor encoding gene EDAR, located on chromosome 2q11–q13 (MIM #604095), or in the EDAR‐associated death domain encoding gene EDARADD, located on chromosome 1q42–q43 (MIM #606603), have been shown to cause both autosomal recessive and dominant HED forms.2 These three forms are clinically indistinguishable, probably because they alter a single signal transduction pathway. This pathway is critical for initiation, formation and differentiation of skin appendages.3 4 5 We report the first case of a female patient with XLHED and bilateral amastia.
Effect of bronchodilation on expiratory flow limitation and resting lung mechanics in COPD
Authors: R. L. Dellacà, P. P. Pompilio, P. P. Walker, N. Duffy, A. Pedotti, P. M. A. Calverley
Journal: European Respiratory Journal (2009)

Bronchodilator drugs produce variable improvements in forced expiratory volume in 1 s (FEV 1 ), but larger changes in end-expiratory lung volume (EELV) in chronic obstructive pulmonary disease (COPD), which were suggested to be related to the presence of expiratory flow limitation (EFL) at rest. We tested this concept in 42 COPD patients (FEV 1 42.3±13.8% predicted) during spontaneous breathing before and after 5 mg nebulised salbutamol. EFL was detected by within-breath changes in respiratory system reactance measured by a multifrequency forced oscillation method, while changes in EELV were assessed by inspiratory capacity (IC). Bronchodilation (BD) increased IC (from 1.8±0.5 to 2.1±0.6 L, p&lt;0.001) and reduced inspiration resistance ( R̄ insp ) at 5 Hz (from 5.1±1.6 to 4.2±1.5 cmH 2 O·s·L −1 , p&lt;0.001). R̄ insp identified BD responders with a discriminative power of 80.1%. In total, 20 patients were flow-limited before BD. They showed worse spirometry and higher residual volume, but significant improvements in IC were seen in all patients irrespective of flow limitation. Changes in R̄ insp were confined to flow-limited patients, as were reactance changes. BD reduced the degree of heterogeneity in the respiratory system, a change best seen with inspiratory values. BD has complex effects on lung mechanics in COPD, and EFL affects both this and the response of some respiratory variables to treatment. However, changes in EELV are consistently seen, irrespective of the presence of flow limitation at rest.
Florid Cushing's Syndrome and Hirsutism Induced by Desoximetasone
Authors: Thep Himathongkam
Journal: JAMA (1978)

CORTICOSTEROIDS have been used topically since 1952 with minimal side effects compared with corticosteroids administered systemically. However, substantial amounts of topically applied corticosteroids may be absorbed percutaneously and cause adrenal suppression.<sup>1</sup>It is surprising that few cases of Cushing's syndrome induced by use of topical steroids have been reported, and those were in children. Cushing's syndrome and hirsutism induced by topically applied desoximetasone (Topicorte) was diagnosed in a woman. <h3>Report of a Cas</h3> A 45-year-old woman was referred to Ramathibodi Hospital for examination for Cushing's syndrome. Two years before admission, hair growth had developed on her face and back to an extent that she had to shave every other day. One year before admission, she experienced reddish striae on her skin and bruising with slight contact. Her weight had increased by 10 kg during the past nine months. She had had psoriasis since age 17 years, and the lesions