tbuckley/cabot-search huggingface dataset:
Recurrent Herpes Simplex Primum Nil Nocete
Authors: Orville J. Stone
Journal: JAMA (1965)

<h3>To the Editor:—</h3> Many dermatologic textbooks and articles include comments on repeated smallpox vaccination for therapy of recurrent herpes simplex. The authors commonly admit that this has no basis in scientific fact and that its effect is psychotherapeutic. My purpose is to challenge the idea of live virus psychotherapy. I am willing to concede the value of psychotherapeutic procedures for certain dermatologic problems, including recurrent herpes simplex. However, there are many reports of death or severe complications that have occurred from smallpox vaccination. Possible death or illness should automatically exclude the procedure from classification as a placebo or as a psychotherapeutic agent. It is not my intention to disagree with the judicious use of vaccination for smallpox immunization. Many of the adverse reactions are probably immunologic, and could be exaggerated by early and frequent repetition. One of the most common complications is erythema multiforme,<sup>1</sup>and I have seen two
Biochemical changes of intervertebral discs in patients with spondylolisthesis or with tears of the posterior annulus fibrosus.
Authors: S Roberts, H K Beard, J P O'Brien
Journal: Annals of the Rheumatic Diseases (1982)

Surgically removed discs from patients with either spondylolisthesis or tears of the posterior annulus fibrosus were analysed for water, proteoglycan, and collagen content and compared with post-mortem control material. Discs from patients with spondylolisthesis had a reduced proteoglycan content in all section sampled and less collagen in the outer annular layers. In contrast discs containing tears in the posterior annulus were unaltered biochemically, although extended studies on 2 patients indicated that there may be localised biochemical changes in the region of the tear itself. Collagen types I, II, and III and proteoglycan distributions were studies qualitatively by immunofluorescence. Collagen types I and III appeared to be reduced in discs from patients with spondylolisthesis, but again little change was found in patients with tears in the posterior annulus fibrosus.
Abstract 5602: Cyclin D2- mediated cardiomyocyte cell cycle activity reverses doxorubicin-induced cardiotoxicity.
Authors: Wuqiang Zhu, Mark H. Soonpaa, Wenjun Zhang, Weinian Shou, Mark Payne, Loren J. Field
Journal: Cancer Research (2013)

Abstract Introduction: Doxorubicin (DOX) is an effective anticancer agent which also induces acute and chronic cardiotoxicities. We have generated a juvenile mouse model to study DOX-induced cardiotoxicity in children. Cardiomyocyte apoptosis with an ensuing loss of myocardial function is observed in this model. Here, we hypothesize that activation of cardiomyocyte cell cycle protects against DOX-induced cardiotoxicity. Methods: Two week old MHC-cylin D2 (D2) mice and their non-transgenic (NON-TXG) littermates were given weekly DOX injections for 5 weeks (25 mg/kg total dose). Animals were studied 1 week (acute stage) or 13 weeks (late stage) after the last DOX injection. Cardiac function was measured with echocardiography and cardiomyocyte (CM) cell cycle was quantified using a tritiated thymidine incorporation assay. Results: Our results showed that CM cell cycle was increased in D2 mice as compared to NON-TXG mice (thymidine positive CM nuclei, 0.03±0.01% vs. 0.002±0.002 in acute stage, p&amp;lt;0.01; and 0.03±0.01% vs. 0.001±0.001 in late stage, p&amp;lt;0.01). In the absence of cell cycle activity, cardiac function remained depressed in late stage vs. acute stage (Fractional Shortening, FS, 41.4±3.1% vs. 44.0±3.2%, p&amp;gt;0.05), whereas in the presence of CM cell cycle activity, cardiac function improved in late stage vs. acute stage (FS = 60.1±1.3% vs. 47.1±3.3%, p&amp;lt;0.01). CM apoptosis (0.02±0.01/mm2 vs. 0.05±0.01/mm2, p&amp;lt;0.01) and fibrosis (6.2±0.9% vs. 12.0±1.7%, p&amp;lt;0.01) was reduced in D2 mice as compared to NON-TXG mice in late stage. Conclusion: For the first time, our data suggest activation of CM cell cycle in adult mice reverses DOX-induced cardiotoxicity. Citation Format: Wuqiang Zhu, Mark H. Soonpaa, Wenjun Zhang, Weinian Shou, Mark Payne, Loren J. Field. Cyclin D2- mediated cardiomyocyte cell cycle activity reverses doxorubicin-induced cardiotoxicity. [abstract]. In: Proceedings of the 104th Annual Meeting of the American Association for Cancer Research; 2013 Apr 6-10; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2013;73(8 Suppl):Abstract nr 5602. doi:10.1158/1538-7445.AM2013-5602
'Coudability': a new physical sign of alopecia areata
Authors: Sam Shuster
Journal: British Journal of Dermatology (1984)

Journal Article 'Coudability': a new physical sign of alopecia areata Get access Sam Shuster Sam Shuster Department of Dermatology, University of Newcastle upon Tyne Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 111, Issue 5, 1 November 1984, Page 629, https://doi.org/10.1111/j.1365-2133.1984.tb06637.x Published: 01 November 1984
Outcomes of Intensive Care Unit Care in Adults with Cystic Fibrosis
Authors: NAMITA SOOD, LINDA J. PARADOWSKI, JAMES R. YANKASKAS
Journal: American Journal of Respiratory and Critical Care Medicine (2001)

Cystic fibrosis (CF) causes progressive respiratory failure and death in more than 90% of patients. Mechanical ventilation has been discouraged in CF because of poor outcomes, but improved survival and the availability of lung transplantation have increased the indications for care of CF patients in the intensive care unit (ICU). We studied the outcomes of all CF patients admitted to the University of North Carolina Hospitals Medical ICU from January 1990 through December 1998. Seventy-six patients, ranging in ages from 17 to 45 yr (mean: 27 yr), and of whom 53% were female, had 136 admissions for exacerbations of CF with respiratory failure (RF, n = 65), hemoptysis (n = 33), antibiotic desensitization (n = 30), pneumothorax (n = 3), or other reasons (n = 5). Eighty-six percent of the patients with hemoptysis and all of those with desensitization and pneumothorax were alive 1 yr after ICU discharge. Of the 42 patients with RF, 37 (88%) required assisted ventilation. Twenty-three (55%) of the patients with RF survived to ICU discharge and 19 (45%) died. Seventeen (40%) of the patients with RF received lung transplants and 14 were alive 1 yr later. Without transplantation, three (7%) of the patients with RF were alive and three (7%) were dead 1 yr later. Sex, body mass index, and respiratory bacteria did not correlate with survival. We conclude that ICU care for adults with CF who have reversible complications is appropriate and effective. Ventilatory support is appropriate for some transplant candidates.
P99 Social deprivation and clinical outcomes in adult CF patients
Authors: A. Ashish, D. Nazareth, A. Tsoulkani, G. Priona, M. Harris, M. Ledson, M. Walshaw
Journal: Thorax (2010)

<h3>Introduction</h3> Economic and social deprivation is associated with increased morbidity and mortality, and this may be particularly important in chronic disease states such as cystic fibrosis, where there is a high burden of care. Despite this, there have been no studies assessing its impact on adult patients with CF. Our large adult CF clinic takes patients from a wide catchment area, including some of the most deprived areas in the country: we wished to study the impact of this deprivation on the health of our CF patients. <h3>Methods</h3> We used the postcode-based Index of Multiple Deprivation (IMD) which takes into account seven domains (including income, education, housing and health-related outcomes), to assign Lower Super Output Areas (LSOAs) in a range of 0–32 486 (where a lower LSOA indicates increased deprivation) to adult patients attending our centre. LSOAs were then correlated with spirometry, BMI, clinic attendances, number and length of inpatient spells, treatment burden, diabetes, and ultimate outcome between 2004 and 2009. Data were analysed using the χ<sup>2</sup> test and bivariate correlations to calculate Pearson9s coefficient, where appropriate. <h3>Results</h3> Of 219 patients (mean age 27.8 years, range 17–65, 99 females), 113 (57%) lived in the lowest 20% of LSOAs (compared to only 20% nationally). We found no correlation between IMD score and FEV1, BMI, hospital admissions, diabetes and death, but there was an inverse relationship (r<sup>2</sup>=−0.153, p&lt;0.05) with the mean length of inpatient stay. <h3>Conclusion</h3> Although many of our adult CF patients live in very deprived areas, this seems to have little impact on their health over a 5-year period, but this is at the expense of more inpatient care, a surrogate marker for more intensive treatment. It is therefore likely that these patients will consume more healthcare resource, and this may need to be factored into any proposed national policy allotting funding towards this complex group of patients.
A Randomized Controlled Trial to Evaluate the Effectiveness of 2 Regimens of Fixed Iodine (131I) Doses for Graves Disease Treatment
Authors: Roberto B. Santos, João H. Romaldini, Laura S. Ward
Journal: Clinical Nuclear Medicine (2012)

Aim: To investigate the effectiveness of 2 fixed iodine (131I) doses for the treatment for Graves hyperthyroidism and their impact on eye disease. Methods: We prospectively examined 76 patients who received a fixed dose of 370 MBq (group 1) and 52 patients who received 555 MBq 131I (group 2). Patients were followed up for 12 months and considered in remission when they were in a stable euthyroid or hypothyroid state in the absence of antithyroid drugs 12 months after 131I administration. Eight patients with active eye disease received a daily dose of 0.5 mg/kg prednisone per kilogram of body weight at the time of radioiodine therapy for 1 month. Results: The remission rate obtained was similar in groups 1 (73.7%) and 2 (80.8%; P = 0.35). Hypothyroidism was diagnosed in 56.5% of the 370-MBq group and 71.1% of the 555-MBq group patients (P = 0.13). There was no correlation among clinical features, thyroid uptake, antibody levels, serum hormones levels, and outcome. However, logistic regression analysis demonstrated that patients with large thyroid glands had 2.4 times less chance to go into remission (odds ratio; 95% confidence interval = 1.18–4.96). None of the patients developed eye disease during any fixed-dose treatment regimen or worsened their previously diagnosed ophthalmopathy. Conclusions: Fixed doses of 370 MBq and 555 MBq 131I provided similar remission rates; however, outcome was influenced by the thyroid size. We propose that 370 MBq 131I should be the routine treatment dose for all Graves disease patients, reserving a dose of 555 MBq 131I to palpable large goiters, without any additional concern to eye disease.
Lymphocyte subpopulations in rheumatoid synovial tissue.
Authors: A Wangel, M Klockars
Journal: Annals of the Rheumatic Diseases (1977)

Synovial tissue obtained at synovectomy of the knee joint in 21 patients with rheumatoid arthritis contained a significantly lower proportion of T lymphocytes as measured by spontaneous rosette formation with nonsensitized sheep red blood cells than did synovial fluid or blood from the same patients. There was on concomitant increase in synovial tissue lymphocytes with B-cell markers such as surface immunoglobulin or Fc fragment receptors. Removal of lymphocyte receptors with trypsin followed by culture to allow new receptors to form, led to an increase in rosette forming cells, suggesting that part of the synovial cells without B- or T-cell markers may be T lymphocytes with blocked receptors.
Newer antipsychotic drugs are no better than older ones, study finds
Authors: Janice Hopkins Tanne
Journal: BMJ (2006)

Older antipsychotic agents are just as effective as the newer, more expensive “second generation” agents, a new study concludes.

The newer drugs, which are almost twice as expensive as the older ones, are no more likely to improve quality of life, say the researchers, from the University of Cambridge and other centres in England ( Archives of General Psychiatry 2006;63: 1079-87).

The study, which was funded by the NHS, reviewed 227 patients aged 18 to 65 years who were users of 14 community psychiatric services in England. The patients had …
Differential Diagnosis of Idiopathic Fibrosis from Malignant Lymphadenopathy with PET and F-18 Fluorodeoxyglucose
Authors: KAZUO KUBOTA, KENJI YAMADA, SEIRO YOSHIOKA, SUSUMU YAMADA, MASATOSHI ITO, TATSUO IDO
Journal: Clinical Nuclear Medicine (1992)

Idiopathic fibrosis and malignant lymphoma were studied with positron emission tomgraphy (PET) using 2-deoxy-2-[F-18]fluoro-D-glucose (F-18DG). Cases of retroperitoneal fibrosis and sclerosing peritonitis showed low F-18DG uptake with the mass/muscle radioactivity (M/M) ratio 2.0 and 1.9, respectively. A case of para-aortic adenopathy from malignant lymphoma showed high F-18DG uptake with the M/M ratio 9.4. F-18DG PET study may be useful for the differential diagnosis of idiopathic fibrosis and malignant lymphadenopathy.
Animal experiments are useful and necessary in understanding cardiovascular disease
Authors: J. F Martin
Journal: Cardiovascular Research (1994)

Journal Article Animal experiments are useful and necessary in understanding cardiovascular disease Get access John F Martin John F Martin King's College, London. UK: Professor J F Martin. Letters relating to this or its companion article should be addressed to The Editor. Cardiovascular Research, Box 2, St Thomas' Hospital, London SEl 7EH. Search for other works by this author on: Oxford Academic PubMed Google Scholar Cardiovascular Research, Volume 28, Issue 7, July 1994, Page 1104, https://doi.org/10.1093/cvr/28.7.1104 Published: 01 July 1994
Drug points: Premature osteonecrosis and sirolimus treatment in renal transplantation
Authors: S. Bhandari, J. Eris
Journal: BMJ (2001)

The incidence of osteonecrosis or avascular necrosis has fallen as a result of new advances in immunosuppression and lower corticosteroid regimens. 1 2 Mycophenolate mofetil and sirolimus are associated with an increase in surgical complications. 3 4 Sirolimus may also be associated with avascular necrosis in patients after renal allograft transplantation. This could be attributed to sirolimus's adverse lipid profile, its potent bone marrow suppressive effect, or perhaps an idiosyncratic …
The Hospital and the Promotion of Health
Authors: William A. Steiger
Journal: New England Journal of Medicine (1969)

THE hospital is the prominent center of medicine today. It is the visible edifice of medical care. No longer is it the poor house or the pesthouse. It is the ultimate in diagnostic depth, in curative power and in rehabilitative potential. However, its efforts to promote health and to prevent disease are minimal, its potential for these purposes having been barely tapped. Municipal departments of public health are usually extra-hospital; medical schools, health departments, and the like establish neighborhood health-care programs, often with only tenuous hospital connections. These are admirable community efforts, but their influence on the central medical structure, . . .
Short-term effect of dynamic exercise on arterial blood pressure.
Authors: L S Pescatello, A E Fargo, C N Leach, H H Scherzer
Journal: Circulation (1991)

To quantify the duration of postexercise hypotension at different exercise intensities, we studied six unmedicated, mildly hypertensive men matched with six normotensive controls.Each subject wore a 24-hour ambulatory blood pressure monitor at the same time of day for 13 consecutive hours on 3 different days. On each of the 3 days, subjects either cycled for 30 minutes at 40% or 70% maximum VO2 or performed activities of daily living. There was no intensity effect on the postexercise reduction in blood pressure, so blood pressure data were combined for the different exercise intensities. Postexercise diastolic blood pressure and mean arterial pressure were lower by 8 +/- 1 (p less than 0.001) and 7 +/- 1 mm Hg (p less than 0.05), respectively, than the preexercise values for 12.7 hours in the hypertensive group. These variables were not different before and after exercise in the normotensive group. Systolic blood pressure was reduced by 5 +/- 1 mm Hg (p less than 0.05) for 8.7 hours after exercise in the hypertensive group. In contrast, systolic blood pressure was 5 +/- 1 mm Hg (p less than 0.001) higher for 12.7 hours after exercise in the normotensive group. When the blood pressure response on the exercise days was compared with that on the nonexercise day, systolic blood pressure (135 +/- 1 versus 145 +/- 1 mm Hg) and mean arterial pressure (100 +/- 1 versus 106 +/- 1 mm Hg) were lower (p less than 0.05) on the exercise days in the hypertensive but not in the normotensive group. We found a postexercise reduction in mean arterial pressure for 12.7 hours independent of the exercise intensity in the hypertensive group. Furthermore, mean arterial pressure was lower on exercise than on nonexercise days in the hypertensive but not in the normotensive group.These findings indicate that dynamic exercise may be an important adjunct in the treatment of mild hypertension.
The epistemological illusion
Authors: Radu J. Bogdan
Journal: Behavioral and Brain Sciences (1995)

Abstract I argue against the mentalist view that commonsense psychology (CSP) is about the intrinsic properties of the mind, and in particular against the notion that the evidence privately or publicly available to the CS psychologists confirms the mentalist view. I suggest that the internal phenomenology of mental attitudes merely provides access to a body of procedural knowledge, and that the propositional forms of the attitudes normally summarize extensive units of procedural knowledge.
Massive cerebral infarction after completion pneumonectomy for pulmonary torsion.
Authors: J Hendriks, P Van Schil, W De Backer, E Hauben, R Vanmaele, E Van Marck
Journal: Thorax (1994)

A case of lower lobe torsion after left upper lobectomy is reported which was complicated by a cerebral infarction after completion pneumonectomy. Results of a small survey in Flanders revealed two additional cases of pulmonary torsion after lobectomy.
Nutrition and cardiovascular disease: Putting a pathogenic framework into focus
Authors: C NAPOLI, W STANLEY, L IGNARRO
Journal: Cardiovascular Research (2006)

In the last two decades it has become clear that dietary recommendations are a key element in the management of cardiovascular disease (CVD). An expanding body of evidence indicates that certain dietary patterns can influence cardiovascular health and primary prevention of CVD by modifying risk factors such as obesity, dyslipidemia, and hypertension as well as factors involved in systemic inflammation, insulin sensitivity, oxidative stress, endothelial function, thrombosis, and cardiac rhythm [1–3]. In the last century dietary and exercise habits have changed, with greater abundance of refined foods and a more sedentary lifestyle, resulting in the rising prevalence of obesity in Western countries [4,5].

In the present Spotlight Issue, we present a series of review articles and original papers with the aim of investigating the various dietary profiles and pathogenic mechanisms that have emerged in the literature and the major studies that investigated their effectiveness in modifying cardiovascular risk. However, we need to keep in mind that long-term adherence can become a problem with some dietary advice that uses severe restriction of certain food groups. Indeed, in trials that investigated the effectiveness of low-carbohydrate diets in inducing weight loss, the attrition rates ranged between 24% and 39%. In most of these trials, comparable attrition rates were observed in subjects assigned to a low-fat diet [6–8]. More important, when a major change in the proportion of one macronutrient is imposed, compensatory changes in the proportions of other macronutrients will naturally occur. In the case of low-carbohydrate diets, there is a concern that excessive dietary protein intake without appropriate quantity of water and beverages can occur and potentially increase long-term risks for nephrolithiasis [9]. Furthermore, when dietary fat intake is severely restricted, biochemical evidence of essential fatty acid deficiency can result. Some clinical consequences have been reported, including episodic … 

*Corresponding author. Tel./fax: +39 081 293399. Email address: claunap{at}tin.it
Gulstonian Lectures on Fever and Inflammation. Delivered before the Royal College of Physicians, London, 1859
Authors: W. Addison
Journal: BMJ (1859)

endency met with among the wool-mill girls.Any one accus- "omed to see the women of the cotton and wool mills, can ,enerally tell, from their appearance, to which mill they belong.rhe cotton-mill girls are generally, though healthy looking, pale, id bleached; whereas the wool girls are rosy and fat.He ilso states that it has been customary, wlhen any young girls bave been noticed whose looks indicated delicacy, to recommend Lhem to change the mill, and that a remarkable effect has often been noticed 1rom a few weeks' work in the wool mill; from the pale, pasty look, they have become healthy and plump.Dr.Simpson states that the great difference and peculiarity in woollen as compared with cotton mills, consists in the fact, that while the hours, the occupation, etc., are much the same in each, in the woollen mills a very large quantity of oil is used, and tlle bodies of the workers are brought, in various ways, freely in contact with it.It is, I believe, in this one item that the great difference between cotton working and wool working consists; anid it is to this material, the oil, as freely used in some of the processes of the wool factories, that the operatives theemselves, universally, and, as I believe, properly, attribute the salutary niature of their occupation.He has also pointed out that the degree of exemption among, the operatives is by no means equal in all the processes of the manufacture, but is regulated by the more or less oily inature of the department of work in which they are engaged.[To be contintued.
Improving palliative care in Africa
Authors: R. A Powell, F. N Mwangi-Powell
Journal: BMJ (2008)

NICE's upper limit of ?30000 (p37000; $47000) per quality adjusted life year and would usually have been rejected.' Andrew Dillon, NICE's chief executive, states that this change would better reflect a general opinion that time at the end of life is more highly valued-a claim that echoes Richards' findings. This comes only a few months after NICE rejected using a rule of rescue on the grounds that it may prejudice decisions against other present and future NHS patients who do not have people to argue on their behalf.( Many may welcome a higher valuation of benefits towards the end of life, but one of the problems with NICE departing from its view that a quality adjusted life year is generally valued the same no matter who ben efits is the ethical difficulty in justifying such selectivity. But there are also problems with the lack of evidence on how much weight society places on different people's lives and how differences in values across society are to be reconciled. Richards' recommendations will no doubt disappoint those who have lobbied for greater diversification in NHS funding and the potential insurance opportunities that top ups could have allowed. But whether the compromises that he-and in particular NICE-have offered mark the final words on the top-ups debate remain to be seen.