tbuckley/cabot-search huggingface dataset:
UK government phases doctors' pay award
Authors: L. Beecham
Journal: BMJ (1997)

The UK government has phased the award recommended by the doctors' pay review body: doctors will receive the first increase on 1 April and the second on 1 December.

The review body recommended an above inflation award of 3.4%; in addition, doctors will receive an extra 0.35% this year and a similar increase in 1998 to take account of relative depreciation in their pensions. However, the government's decision to phase the award means that the total increase over the year will be 2.8%. Doctors will receive 2.35% on 1 April and 1.4% from 1 December. The Labour party says that it will honour the phasing decision if it comes into power.

The review body's recommendations have been implemented in full only five times since 1980, and the BMA has condemned yet another interference. The chairman of the BMA council, Dr Sandy Macara, said that the decision “will be regarded as a disgraceful betrayal of trust. What kind …
Transport of 22Na and 86Rb tracer ions in isolated contracting heart cells exposed to lignocaine
Authors: A. EISALO, A. KAHRI, K. KARPPINEN, V. MANNINEN
Journal: Cardiovascular Research (1973)

Transfer of sodium and rubidium tracer ions in lignocaine-treated primary culture of contracting heart cells was studied. In suitable concentrations lignocaine reduced the rate of these ion flows. Connection of the present results with membrane stabilization and previous reports about the electrophysiological mode of action of lignocaine is briefly discussed.
Methods of Disinfecting Endoscopic Material: Results of an International Survey
Authors: A. Van Gossum, M. Loriers, E. Serruys, M. Cremer
Journal: Endoscopy (1989)

See also: Presence of Sebaceous Glands in the EsophagusEndoscopy 1991; 23(06): 353-354DOI: 10.1055/s-2007-1010720 See also: Lack of Evidence of Upper Gastrointestinal Endoscopy as a Risk Factor for Transmission of Hepatitis B VirusEndoscopy 1991; 23(06): 353-353DOI: 10.1055/s-2007-1010719
EXPRESSION OF INFLAMMATORY CYTOKINES IN PERICARDIAL AND SUBCUTANEOUS ADIPOSE TISSUE ON CORONARY ARTERY DISEASE
Authors: Ryo Tsuruta, Katsumi Miyauchi, Takayoshi Suganami, Hirotaka Inaba, Taira Yamamoto, Kenji Kuwaki, Shizuyuki Dohi, Tomotaka Dohi, Yoshihiro Ogawa, Hiroyuki Daida, Atsushi Amano
Journal: Journal of the American College of Cardiology (2011)
Spirit Possession and Healing Cult among the Brasilian Umbanda
Authors: Horst H. Figge
Journal: Psychotherapy and Psychosomatics (1975)

million adherents especially in the bigger Cities. It may be characterized as an extraecclesiastic consolidation of popular catholicism within the vacant forms of ancient Afro -Brasilian sects. The central belief is the existence of all sorts of spirits; a central task is to give them the opportunity temporarily to take ho ld of human bodies. There may be a hundred thousand or more trained incorporation-mediums in Brazil by now, that is, people who in certain in stances believe, and are thought by others, to be spirits. The Umbanda groups meet once to three times a week, mostly at night and in their Centers, which resemble Catholic chape ls. The groups consist of ten to 50 or more spirit mediums and of fewer assistants. All the different sessions are open to the public. Pass ive believers prefer by far those sessions in which they are given the poss ibility to enter into direct contact with the embodied spirits. There are, roughly speaking, five categories of spi rits called and embodied in Umbanda: deities of nature (who are seen in clos e connection to Catholic saints), old people, good and bad people o f middle age, and children. All of them show a semi-standardized beha vior. Personally known dead are seldom or never called. There is no cult session at all without the presenc e of embodied spirits. The priest himself always is a medium and he leads the group and the sessions mainly through his different spirit roles. Every de veloped medium is the 'horse', as it is called, of at least one spirit of each category, generally of more. Mediums are free to incorporate any spirit , male or female of any category - or in the language of Umbanda: th e spirits are free to choose any medium. Umbanda does not know any organisation or leadership above the level of the thousands of cult-groups. Groups form around certain priests
Fluorodeoxyglucose positron emission tomography (FDG-PET) for monitoring lymphadenopathy in the autoimmune lymphoproliferative syndrome (ALPS)
Authors: V. Koneti Rao, Jorge A. Carrasquillo, Janet K. Dale, Stephen L. Bacharach, Millie Whatley, Faith Dugan, Jean Tretler, Thomas Fleisher, Jennifer M. Puck, Wyndham Wilson, Elaine S. Jaffe, Nilo Avila, Clara C. Chen, Stephen E. Straus
Journal: American Journal of Hematology (2006)

Autoimmune lymphoproliferative syndrome (ALPS) is associated with mutations that impair the activity of lymphocyte apoptosis proteins, leading to chronic lymphadenopathy, hepatosplenomegaly, autoimmunity, and an increased risk of lymphoma. We investigated the utility of fluorodeoxyglucose positron emission tomography (FDG-PET) in discriminating benign from malignant lymphadenopathy in ALPS. We report that FDG avidity of benign lymph nodes in ALPS can be high and, hence, by itself does not imply presence of lymphoma; but FDG-PET can help guide the decision for selecting which of many enlarged nodes in ALPS patients to biopsy when lymphoma is suspected.
Lack of Efficacy of Hydergine in Patients with Alzheimer's Disease
Authors: Troy L. Thompson, Christopher M. Filley, Wayne D. Mitchell, Kathleen M. Culig, Mary LoVerde, Richard L. Byyny
Journal: New England Journal of Medicine (1990)

There is no effective pharmacologic treatment for Alzheimer's disease, the most common dementing illness in the United States. Hydergine, a combination of ergoloid mesylates, is the only approved medication for Alzheimer's disease, but despite widespread use its efficacy remains to be established. We conducted a clinical trial of Hydergine-LC, a newer preparation of ergoloid mesylates in the form of a liquid in a capsule (LC) that may have greater bioavailability, to determine its value in patients with Alzheimer's disease.
Distinct Differences in Gene Expression Patterns in Pulmonary Arteries of Patients with Chronic Obstructive Pulmonary Disease and Idiopathic Pulmonary Fibrosis with Pulmonary Hypertension
Authors: Julia Hoffmann, Jochen Wilhelm, Leigh M. Marsh, Bahil Ghanim, Walter Klepetko, Gabor Kovacs, Horst Olschewski, Andrea Olschewski, Grazyna Kwapiszewska
Journal: American Journal of Respiratory and Critical Care Medicine (2014)

The development of pulmonary hypertension (PH) in patients with idiopathic pulmonary fibrosis (IPF) or chronic obstructive pulmonary disease (COPD) is associated with increased morbidity.To elucidate whether vascular remodeling in a well-characterized PH-COPD and PH-IPF patient cohort results from similar or divergent molecular changes.Vascular remodeling of donor, PH-COPD, and PH-IPF pulmonary arteries was assessed. Laser capture microdissected pulmonary artery profiles in combination with whole genome microarrays were performed.Pulmonary arteries from patients with COPD and IPF with PH exhibited remodeling of vascular layers and reduction of lumen area. Pathway analyses comparing normalized gene expression profiles obtained from patients with PH-IPF or PH-COPD revealed the retinol and extracellular matrix (ECM) receptor interaction to be the most perturbed processes. Within the ECM-receptor pathway, differential regulation of 5 out of the top 10 results (collagen, type III, α-1; tenascin C; collagen, type VI, α-3; thrombospondin 2; and von Willebrand factor) were verified by real-time polymerase chain reaction and immunohistochemical staining.Despite clinical and histologic vascular remodeling in all patients with PH-COPD and PH-IPF, differential gene expression pattern was present in pulmonary artery profiles. Several genes involved in retinol metabolism and ECM receptor interaction enable discrimination of vascular remodeling in PH-IPF or PH-COPD. This suggests that pulmonary arterial remodeling in PH-COPD and PH-IPF is caused by different molecular mechanisms and may require specific therapeutic options.
Chlorpropamide-alcohol flushing and microangiopathy in insulin-dependent diabetes.
Authors: A H Barnett, P J Mace, D A Pyke
Journal: BMJ (1981)

As retinal changes usually precede the development of diabetic nephropathy, in the five patients with proteinuria but without retinopathy (three positive and two negative for chlorpropamide- alcohol flushing) the proteinuria may possibly have been due to other causes.If these cases are excluded the difference between the groups positive and negative for flushing becomes greater (1/191 (0 5 ) v 12/100 (120;).
Short-Term Effect of Red Wine (Consumed During Meals) on Insulin Requirement and Glucose Tolerance in Diabetic Patients
Authors: Henri Gin, Philippe Morlat, Jean M Ragnaud, Jean Aubertin
Journal: Diabetes Care (1992)

Objectives To determine the effect of wine on insulin requirement or glucose tolerance. Research Design and Methods Five men with insulin-treated diabetes and 10 men with non-insulin-treated diabetes ate the same lunch with the same volume of either water or red wine (2 glasses). Insulin requirement was determined with an artificial pancreas (Biostator). Glucose tolerance was evaluated from the postprandial glycemic level. Results There was no significant difference in insulin requirement determined with an artificial pancreas in the insulin-treated patients after the two meals (31.5 ± 4.21 U with water and 31.8 ± 4.3 U with wine). Glucose tolerance in the non-insulin-treated patients was lower after the meal with wine. Conclusions Moderate prandial wine consumption has no adverse effect on the glycemic control of diabetic patients. Thus, it appears unnecessary to proscribe the consumption of red wine in moderation with meals to diabetic patients. Wine contains tannins and phytates that can explain its action.
Maximum oxygen consumption rate and dihydrogenated ergot alkaloids in humans.
Authors: T. Ingemann-Hansen, J. Halkjaer-Kristensen
Journal: British Journal of Sports Medicine (1984)

The relationship of maximal oxygen uptake (VO2 max) with dihydrogenated ergot alkaloids was investigated in twelve young men. They were subjected to graded bicycle exercise with work loads corresponding to 75% and 120% of the load necessary to elicit VO2 max. The exercise tests were performed after intravenous administration of 2 mg dihydroergostin (DE-145) as well as after saline as control, both preparations were given double-blind. VO2 max averaged (SD) 3.36 (0.41) 1/min and no significant difference was disclosed between the DE-145 and the control situation. Normal relationships were observed between VO2 and work load, ventilation, heart rate, cardiac output, central venous pressure and acid-base data, and these relations were unaffected by DE-145 administration. Nausea was constantly seen in all subjects tested with DE-145. It is concluded, that the present dose of DE-145 has no influence on the functional capacity of the oxygen transporting system in sedentary young men.
Dissection of serological and cytolytic T lymphocyte epitopes on murine major histocompatibility antigens by a recombinant H-2 gene separating the first two external domains.
Authors: C Murre, E Choi, J Weis, J G Seidman, K Ozato, L Liu, S J Burakoff, C S Reiss
Journal: The Journal of Experimental Medicine (1984)

A novel H-2 gene in which the first external (N) domain of the H-2Ld antigen was replaced with that of the H-2Dd antigen was constructed and introduced into L cells. A transformant expressing the products of the hybrid gene was studied for binding to monoclonal antibodies specific for H-2Ld and H-2Dd antigens. It was found that serological determinants are distributed both in the N (Dd) and Cl (Ld) domains. Determinants recognized by allospecific cytotoxic T lymphocytes (CTLs) and virus-specific CTLs also mapped to the N and Cl domains. Determinants recognized by vesicular stomatitis virus (VSV)-specific effect cells, however, were not present on the recombinant molecule. These results show that a recombinant gene of two H-2 antigens in which the first external domain has been reshuffled can express a functional H-2 antigen that can then be used to map serological and CTL determinants to specific domains.
Prognosis of Men with Coronary Heart Disease as Related to Blood Pressure
Authors: CHARLES W. FRANK, EVE WEINBLATT, SAM SHAPIRO, ROBERT V. SAGER
Journal: Circulation (1968)

Hypertension prior to the onset of the initial myocardial infarction in men is associated with an excess early mortality rate: among men with elevated blood pressure the proportion dead within 1 month is more than twice that found among normotensive men with a first infarction. Hypertensives who survive the acute attack show twice the risk of recurrence and more than five times the risk of cardiac death over the next several years in comparison with men with normal blood pressure prior to infarction. Among men whose first clinical evidence of coronary disease is angina pectoris, those with an elevated blood pressure have two and one half times the likelihood of experiencing a first myocardial infarction and cardiac death within a follow-up period of 30 months. These findings are from the HIP (Health Insurance Plan of Greater New York) study of the incidence and prognosis of coronary heart disease, an ongoing prospective study of a general population of 110,000 men and women aged 25 to 64 years.
Cortical Pain Image or Pain-sensitivity Panel
Authors: G. W. Theobald
Journal: BMJ (1965)

Pain is an apperceptive mental experience which can only be studied in man. It cannot be measured or even satisfactorily described except to those who have suffered like pain, and the similarity is always an assumption. The purpose of this paper is to propound the following hypothesis, which consists of two main parts: (1) that pain is meant to subserve a purely protec tive function and merely to cause sufficient discomfort to warn of noxious stimuli and to make the animal take appropriate action, such as to move from harm or rest a limb ; and (2) that the affective or cortical component of pain, or the pain image, can be envisaged as a panel comparable with a multi-channel electromanometric recording apparatus, which allows the size of the image or the amount of deflection of the pen to be varied by turning knobs on the panel which change its sensi tivity. It will be shown that pain sensitivity can be affected by (a) psychical, and (b) peripheral factors, and that it may also be modified in the spinal cord. The thesis will be supported by gynaecological experience, which gave it birth.
Normophosphatemic Vitamin D-Resistant Osteomalacia in a Patient with Normal Calcium and Fat Absorption
Authors: MORDECHAI WARON
Journal: Annals of Internal Medicine (1971)

The clinical data, calcium metabolic studies, and histological examination of bone in a patient with severe progressive bone demineralization are discussed with respect to the etiology of the bone disease. Several features are consistent with osteomalacia: multiple pseudofractures, subperiosteal resorption, hypocalcemia, increased calcium retention after an intravenous infusion of calcium, decreased bone apposition, and increased amount of bone surface lined by osteoid. Osteoid seam width was not increased, however, and fat and calcium absorption and response to an NH4Cl load all were normal. Because vitamin D antirachitic activity was present in serum, and treatment with vitamin D and sodium fluoride did not lead to clinical improvement, this patient may have an acquired abnormality of bone cells associated with progressive skeletal demineralization and plastic deformities.
Cells of the Hepatic Sinusoid, Vol. 2. Edited by E. Wisse, D. L. Knook and K. Decker, 508 pp. the Netherlands: Kupffer Cell Foundation, 1989. $100.00
Authors: Irwin M. Arias
Journal: Hepatology (1990)

HepatologyVolume 11, Issue 5 p. 900-901 Book ReviewFree Access Cells of the hepatic sinusoid, Vol. 2. Edited by E. Wisse, D. L. Knook and K. Decker, 508 pp. The Netherlands: Kupffer Cell Foundation, 1989. $100.00 Irwin M. Arias M. D., Irwin M. Arias M. D. Tufts University School of Medicine Boston, MA 02111Search for more papers by this author Irwin M. Arias M. D., Irwin M. Arias M. D. Tufts University School of Medicine Boston, MA 02111Search for more papers by this author First published: May 1990 https://doi.org/10.1002/hep.1840110536AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinked InRedditWechat No abstract is available for this article. Volume11, Issue5May 1990Pages 900-901 RelatedInformation
Teaching Creatively With Video: Fostering Reflection, Communication and Other Clinical Skills
Authors: Bruce L. Gewertz
Journal: JAMA (1994)

This concise book is clear in its goals: providing both the theoretical justifications and the specific technical considerations involved in using video for health care education. The authors are authorities who have made substantial contributions in the literature and in frequent seminars with medical educators, in which the practical consequences of the video approach can be tested. They contend that video archiving of student-patient interactions, followed by thoughtful evaluation by instructors, peers, and the students themselves, can best turn students from passive learners to active learners. There is much to be said in support of the authors' hypothesis and of the simplified style and typographically varied format of their book. Each chapter begins with the rationale for using video for various purposes (eg, to illustrate, model, and evaluate) and concludes with precise directions and, often, detailed checklists to assure optimum benefits. An excellent glossary of video production terms is provided.
Chemotherapy of acute lymphoblastic leukemia in children
Authors: Mahroo Haghbin
Journal: American Journal of Hematology (1976)

Abstract Between 1969‐1973, 75 consecutive children under the age of 15 years with acute lymphoblastic leukemia were treated with a multiple‐drug regimen (L‐2). Prophylaxis for meningeal leukemia was limited to the repeated intrathecal injections of methotrexate. Seventy‐four patients achieved remission; the duration of remissions could be evaluated only for 70. Relapse terminated complete remission within 1‐54 months in 21 children. Four of these relapses were confined to the central nervous system. Forty‐nine patients continue in complete remission from 23 to 63 months. Chemotherapy has been discontinued in 29 children, and 25 of these remain without evidence of recurrence for 2‐27 months posttreatment.
Colour Disturbance as a Symptom
Authors: M. J. Pleydell
Journal: BMJ (1975)

Flyweight 3000 50 60 70 80 90 00 110 Body weight ( kg)Body Weight and Performance in Weighdifeing Events (Munich 0lymnpic Medalists, 1972).advantages: greater weight because of his height and greater leverage.The sportig system is ibiased in favour of the taller sec- tions of the population; persons of average height, no matter how good they are within the physial limitation of thei build, are virtually dearred fron some events.12IPTob-ably shorer competitors m the throwng and rowing events are tempted to use steroids to gain in weight what they lack in height.Buut they cannot match the advantages taller com- petitors (of the same weight) have because of better leverage.There is need to empha- size that the use of anabolic steroids will not help to win medals in a large majority of cases.I suggest the administrators of ath- letics re-examine some of the basic assumptions upon whidh these events ae regulated.-I am etc.,
Azathioprine in the treatment of muco-cutaneous pemphigoid
Authors: VINAY K. DAVE, C. F. H. VICKERS
Journal: British Journal of Dermatology (1974)

Four patients with muco‐cutaneous pemphigoid were treated with azathioprine. Satisfactory control of the cutaneous lesions was maintained in two patients, in one of them with concomitant use of a corticesteroid. Oral ulceration was less frequent in three patients, and in two patients with ocular involvement visual impairment did not progress. Although the various complications of azathioprine therapy need to be considered, this drug may significantly improve the prognosis regarding vision in patients with ocular changes otherwise totally unresponsive to therapy.
Recognition of Atypical Reflex Sympathetic Dystrophy
Authors: LARRY L. HECK
Journal: Clinical Nuclear Medicine (1987)

Previous reports of radionuclide imaging have emphasized the hyperemic response and increased rate of bone metabolism in patients with reflex sympathetic dystrophy syndrome (RSD). The atypical presentation to the nuclear medicine physician of this clinical entity occurs when there is decreased rather than increased perfusion to the effected extremity. This clinical presentation may be more commonly seen as patients attempt to continue to exercise on a painful extremity. The cases in this paper emphasize the vasospastic abnormalities that occasionally may be predominant and the importance of early diagnosis of the disorder. The peripheral perfusion may be improved with interventional therapy to decrease sympathetic vasoconstrictive effect.
New Organization Promotes Patient-Oriented Research
Authors: M. J. Friedrich
Journal: JAMA (1999)

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