EXTRACELLULAR HYPEROSMOLARITY SECONDARY TO HIGH-PROTEIN NASOGASTRIC TUBE FEEDING
Authors: W S WILSON, J K MEINERT
Journal: Annals of Internal Medicine (1957)

Case Reports1 September 1957EXTRACELLULAR HYPEROSMOLARITY SECONDARY TO HIGH-PROTEIN NASOGASTRIC TUBE FEEDINGWILLIAM S. WILSON, M.D., JOHN K. MEINERT, M.D.WILLIAM S. WILSON, M.D.Search for more papers by this author, JOHN K. MEINERT, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-47-3-585 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptHyperosmolarity exists in the extracellular fluid when the concentrations of solutes is increased above the normal range.The cellular membrane is considered to be relatively impermeable to the sodium ion, and for this reason the extracellular sodium concentration is much higher than is the intracellular sodium concentration. Because of this concentration gradient, the sodium ion concentration is an important factor in determining the effective osmotic pressure of the extracellular fluid,1 and extracellular hyperosmolarity is most commonly associated with extracellular hypernatremia.Hypo-osmolarity is a rather common clinical condition. Diarrhea, chronic glomerulonephritis, and mercurial diuresis with restriction of sodium intake are among...Bibliography1. Peters JP: Sodium, water and edema, J. Mt. Sinai Hosp. 17: 159-175, 1950-1951. MedlineGoogle Scholar2. SchoolmanDubinHoffman HAW: Clinical syndromes associated with hypernatremia, Arch. Int. Med. 95: 15-23, 1955. CrossrefGoogle Scholar3. EngelJaeger FLC: Dehydration with hypernatremia, hyperchloremia and azotemia complicating nasogastric tube feeding, Am. J. Med. 17: 196-204, 1954. CrossrefMedlineGoogle Scholar4. Smith H: The kidney: structure and function in health and disease, 1951, Oxford Medical Publications, New York, p. 135. Google Scholar5. ElkintonTaffel JRM: Prolonged water deprivation in the dog, J. Clin. Investigation 21: 787-794, 1942. CrossrefMedlineGoogle Scholar6. WinklerDanowskiElkintonPeters AWTSJRJP: Water deprivation and starvation in man, J. Clin. Investigation 23: 807-815, 1944. CrossrefMedlineGoogle Scholar7. Verney EB: Croonian lecture: The antidiuretic hormone and the factors which determine its release, Proc. Royal Soc. B135: 25-106, 1947. Google Scholar8. McCance RA: Medical problems in mineral metabolism. III. Experimental human salt deficiency, Lancet 1: 823-830, 1936. CrossrefGoogle Scholar9. HolmesCizek JHLJ: Observations on sodium chloride depletion in the dog, Am. J. Physiol. 164: 407-414, 1951. CrossrefMedlineGoogle Scholar10. PareiraConradHicksElman MDEJWR: Therapeutic nutrition with tube feeding, J. A. M. A. 156: 810-816, 1954. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: *Received for publication July 2, 1956.From the Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan.Requests for reprints should be addressed to William S. Wilson, M.D., Heart Station, University Hospital, Ann Arbor, Michigan. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byPrinciples of quantitative water and electrolyte replacement of losses from osmotic diuresisTube Feeding Syndrome RevisitedProtein-induced hyperthermia for liver cancer treatmentExtreme Hypernatraemia in a Child Receiving Gastrostomy FeedingNonketotic hyperglycemic hyperosmolar comaHypernatremia following gastrointestinal bleeding in cirrhosis with ascitesMetabolic response to surgery in relation to caloric, fluid and electrolyte intakeThe surgical significance of hyperosmolar comaHypernatremia, Azotemia, and Dehydration Due to High-Protein Tube FeedingM. HENRY GAULT, M.D., M.SC., F.A.C.P., MICHAEL E. DIXON, M.D., F.R.C.P.(C), MICHAEL DOYLE, M.D., WALTER M. COHEN, M.D. 1 September 1957Volume 47, Issue 3Page: 585-590KeywordsAttentionDiarrheaGlomerulonephritisHypernatremiaIngestionOsmotic pressureProteinsSodium ePublished: 1 December 2008 Issue Published: 1 September 1957 PDF downloadLoading ...