tbuckley/cabot-search huggingface dataset:
Abstract 911: Prostate-specific membrane antigen (PSMA) expression as a potential patient selection marker in patients with refractory solid tumors administered BIND-014, a PSMA-targeted nanoparticle containing docetaxel
Authors: Susan Low, Daniel Von Hoff, Monica Mita, Howard Burris, Peter Eisenberg, Lowell Hart, Patricia LoRusso, Glen Weiss, Jasgit Sachdev, Alain Mita, Ramesh Ramanathan, Jeff Hrkach, Jason Summa, Gregory Berk
Journal: Cancer Research (2014)

Abstract Background: Prostate-specific membrane antigen (PSMA) is a transmembrane protein that is overexpressed in prostate adenocarcinomas and in non-prostatic tumor neovasculature. As a novel target for therapeutic approaches, the distribution pattern of PSMA in primary and metastatic tumors is of significant interest. In this study we addressed the cellular distribution and heterogeneity of PSMA expression in solid tumors from patients on a phase 1 study of BIND-014, a PSMA-targeted nanoparticle containing docetaxel.Methods: Paraffin-embedded sections of surgical specimens from 1 patient (pt) with prostate carcinoma and 4 pts with non-prostatic tumors (cervical, NSCLC, breast and hepatobiliary) were evaluated. Immunohistochemistry by platelet endothelial cell adhesion molecule (CD31) for the detection of endothelial cells and monoclonal mouse anti-human PSMA (Clone 3E6) for detection of PSMA were used to determine the cellular localization and staining intensity for each tumor type. Results: All pts evaluated experienced some clinical benefit from BIND-014 (including complete response, partial response or stable disease) which is targeted to PSMA. We demonstrated differences in staining intensity and localization of PSMA in neoplastic epithelium and neoplastic tissue-associated blood vessels. PSMA was detected in the epithelium of prostate tissue and in neoplastic tissue-associated vessels of cervical, anal, NSCLC, and hepatobiliary cancers. PSMA was not detected in benign tissue of any specimens evaluated. Conclusions: Our findings support the feasibility of developing this assay as a companion diagnostic to potentially select patients who may benefit from PSMA-directed targeted therapy. Ongoing Phase 2 studies with BIND-014 include further PSMA expression analysis. Citation Format: Susan Low, Daniel Von Hoff, Monica Mita, Howard Burris, Peter Eisenberg, Lowell Hart, Patricia LoRusso, Glen Weiss, Jasgit Sachdev, Alain Mita, Ramesh Ramanathan, Jeff Hrkach, Jason Summa, Gregory Berk. Prostate-specific membrane antigen (PSMA) expression as a potential patient selection marker in patients with refractory solid tumors administered BIND-014, a PSMA-targeted nanoparticle containing docetaxel. [abstract]. In: Proceedings of the 105th Annual Meeting of the American Association for Cancer Research; 2014 Apr 5-9; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2014;74(19 Suppl):Abstract nr 911. doi:10.1158/1538-7445.AM2014-911
Abstract 3663: Immune suppressive myeloid cells expansion in vitro requires a simulated tumor microenvironment
Authors: Joseph Markowitz, Taylor R. Brooks, William E. Carson
Journal: Cancer Research (2014)

Abstract Elevated levels of immune suppressor cells induced by tumor derived factors are associated with inhibition of immune responses. One such group of immune suppressor cells is Myeloid Derived Suppressor Cells (MDSCs). They are phenotypically defined in humans as HLADR low or negative and CD33, CD11b, and CD15 or CD14 positive and functionally by their ability to suppress the activation of other immune cells such as T cells. We hypothesized that MDSCs generated in vitro could be propagated but would lose their suppressive ability on the action of T cells in the absence of a simulated tumor microenvironment. MDSCs were first differentiated in vitro from normal donor peripheral blood mononuclear cells (PBMCs) using a simulated tumor microenvironment consisting of either cytokines (GMCSF and IL-6) or tumor cell lines (pancreatic adenocarcinoma SW-1990 or head and neck cancer CAL-27). The MDSCs generated in vitro suppressed T cell proliferation of autologous T cells using the carboxyfluorescein succinimidyl ester (CFSE) assay (31%, 46% and 75% suppression for cytokines, CAL-27 and SW-1990, respectively). Given the MDSCs obtained from co-culture of PBMCs with SW-1990 were the most suppressive on the proliferation of T cells, we attempted to proliferate these cells in vitro to expand the number of MDSC available for experimentation rather than having to purify MDSC from clinical samples. In vitro generated MDSC were propagated using a Rho-associated kinase (ROCK) inhibitor. Generated MDSC collected via magnetic bead isolation (CD33) were cultured with irradiated fibroblast feeder cells (± 3000 rad) in F medium [3:1 (v/v) F-12 Nutrient Mixture (Ham)-Dulbecco's modified Eagle's medium, 5% fetal bovine serum, 0.4 µg/mL hydrocortisone, 5 µg/mL insulin, 8.4 ng/mL cholera toxin, 10 ng/mL epidermal growth factor (or 10 ng/mL GMCSF), and 24 µg/mL adenine]. The ROCK inhibitor was added at 10 µM and the media was exchanged every 3 days. The generated MDSC did propagate as measured by CFSE staining of the generated MDSC; however, the generated MDSCs completely lost their ability to inhibit T cells by day 11 in culture. In conclusion, generated MDSCs can be propagated in culture but lose their ability to suppress T cells in the absence of a simulated tumor microenvironment and the presence of a Rho kinase inhibitor. Citation Format: Joseph Markowitz, Taylor R. Brooks, William E. Carson. Immune suppressive myeloid cells expansion in vitro requires a simulated tumor microenvironment. [abstract]. In: Proceedings of the 105th Annual Meeting of the American Association for Cancer Research; 2014 Apr 5-9; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2014;74(19 Suppl):Abstract nr 3663. doi:10.1158/1538-7445.AM2014-3663
Functional analysis of secreted and transmembrane proteins critical to mouse development
Authors: Kevin J. Mitchell, Kathy I. Pinson, Olivia G. Kelly, Jane Brennan, Joel Zupicich, Paul Scherz, Philip A. Leighton, Lisa V. Goodrich, Xiaowei Lu, Brian J. Avery, Peri Tate, Kariena Dill, Edivinia Pangilinan, Paul Wakenight, Marc Tessier-Lavigne, William C. Skarnes
Journal: Nature Genetics (2001)
Impaired Coronary Vascular Reactivity and Functional Capacity in Women
Authors: Eileen Handberg, B. Delia Johnson, Christopher B. Arant, Timothy R. Wessel, Richard A. Kerensky, Gregory von Mering, Marian B. Olson, Steven E. Reis, Leslee Shaw, C. Noel Bairey Merz, Barry L. Sharaf, George Sopko, Carl J. Pepine
Journal: Journal of the American College of Cardiology (2006)
Evidence of effectiveness of audit in improving care is growing
Authors: R. Baker, R. C Fraser
Journal: BMJ (1996)

EDITOR,—Andrew Miles and colleagues' letter about audit exemplifies the confusion in the debate about the achievements of the national audit programme.1 There are misunderstandings about the true nature of audit among both clinicians and researchers, and this results in opinions that are poorly supported by evidence. In evaluating the impact of audit it is essential to distinguish between audit as a method and the way in which it has been implemented. Although only …
The Oxidative Stress Network of Mycobacterium tuberculosis Reveals Coordination between Radical Detoxification Systems
Authors: Subhalaxmi Nambi, Jarukit E. Long, Bibhuti B. Mishra, Richard Baker, Kenan C. Murphy, Andrew J. Olive, Hien P. Nguyen, Scott A. Shaffer, Christopher M. Sassetti
Journal: Cell Host & Microbe (2015)
Hearing loss and coronary heart disease
Authors: S Rosen, P Olin
Journal: JAMA (1965)

Hearing tests were carried out in 1961, 1962, and 1963 among members of the isolated Mabaan tribe which for centuries has lived in virtual silence in the jungle of southeast Sudan. At all frequencies (500 to 24,000 cps) and all ages, their hearing is far superior to any previously recorded. Equally interesting are measurements of their systolic and diastolic blood pressures which are comparable at 15 and 75 years of age; coronary heart disease is unknown. The tribe's main food is millet, some fish, nuts, wild dates, and little meat. Members of the tribe are muscular and well postured at all ages, physically active, never obese, do not smoke, age slowly and are agile in their seventies and eighties. The mean cholesterol level is 160 mg/ 100 ml. Occasionally a tribal member moves to the city of Khartoum, and subsequently develops hypertension and coronary heart disease. In the United States,
Effect of parasite infection on allergic disease
Authors: M. Capron
Journal: Allergy (2011)

Vertebrates and helminths have co-evolved for 500 million years, developing mutual adaptation mechanisms between parasites and hosts. Today, however, helminth diseases are among the most neglected communicable diseases. Epidemiological evidence shows that exposure to helminth parasites is inversely correlated with allergy incidence, and helminths induce immune hyporeactivity in both the innate and adaptive systems. The mechanisms include parasite-derived regulatory molecules, the study of which opens new avenues for the control of allergic and autoimmune diseases.
Abstract 16364: The Triglycerides to High-density Lipoprotein Cholesterol Ratio, a Predictor of the LDL-C Particle Size, is Associated with Coronary Plaque Regression
Authors: Michiaki Matsumoto, Sigemasa Tani, Takao Anazawa, Hirofumi Kawamata, Shingo Furuya, Hiroshi Takahashi, Kiyoshi Iida, Takehiko Washio, Narimichi Kumabe, Ken Nagao, Atsushi Hirayama
Journal: Circulation (2010)

Background: We reported that elevated body mass index (BMI) show delayed coronary plaque regression by statin. However, the underlying mechanisms are still unknown. The purpose of this study was to...
Long-term efficacy of etanercept for psoriasis in daily practice
Authors: P.P.M. Van Lümig, R.J.B. Driessen, J.B.M. Boezeman, P.C.M. Van De Kerkhof, E.M.G.J. De Jong
Journal: British Journal of Dermatology (2011)

Journal Article Long‐term efficacy of etanercept for psoriasis in daily practice Get access P.P.M. Van Lümig, P.P.M. Van Lümig Department of Dermatology, Radboud University Nijmegen Medical Centre, 6525 GL Nijmegen, the Netherlands E‐mail: P.vanLumig@derma.umcn.nl Search for other works by this author on: Oxford Academic Google Scholar R.J.B. Driessen, R.J.B. Driessen Department of Dermatology, Radboud University Nijmegen Medical Centre, 6525 GL Nijmegen, the Netherlands E‐mail: P.vanLumig@derma.umcn.nl Search for other works by this author on: Oxford Academic Google Scholar J.B.M. Boezeman, J.B.M. Boezeman Department of Dermatology, Radboud University Nijmegen Medical Centre, 6525 GL Nijmegen, the Netherlands E‐mail: P.vanLumig@derma.umcn.nl Search for other works by this author on: Oxford Academic Google Scholar P.C.M. Van De Kerkhof, P.C.M. Van De Kerkhof Department of Dermatology, Radboud University Nijmegen Medical Centre, 6525 GL Nijmegen, the Netherlands E‐mail: P.vanLumig@derma.umcn.nl Search for other works by this author on: Oxford Academic Google Scholar E.M.G.J. De Jong E.M.G.J. De Jong Department of Dermatology, Radboud University Nijmegen Medical Centre, 6525 GL Nijmegen, the Netherlands E‐mail: P.vanLumig@derma.umcn.nl Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 166, Issue 2, 1 February 2012, Pages 445–447, https://doi.org/10.1111/j.1365-2133.2011.10584.x Published: 01 February 2012
Reply to Pranav Sharma, Asad Sawar and Philippe Spiess’ Letter to the Editor re: Re: Craig Rogers, Ravi Barod, Scott Schwartz, Mani Menon. Endovascular Extraction of Caval Tumor Thrombus to Facilitate Minimally Invasive Cytoreductive Nephrectomy for Metastatic Kidney Cancer. Eur Urol 2015;68:167–8
Authors: Craig G. Rogers, Ravi Barod, Scott Schwartz, Mani Menon
Journal: European Urology (2015)
A randomized comparative study of tolerance and satisfaction in the treatment of actinic keratosis of the face and scalp between 5% imiquimod cream and photodynamic therapy with methyl aminolaevulinate
Authors: C. Serra-Guillen, E. Nagore, L. Hueso, B. Llombart, C. Requena, O. Sanmartín, R. Botella-Estrada, C. Guillen
Journal: British Journal of Dermatology (2010)

Photodynamic therapy (PDT) and imiquimod are two excellent treatments for actinic keratosis but are often not well tolerated by patients.To ascertain which treatment is better tolerated and which produces greater patient satisfaction. A secondary objective was to determine the factors related to the patient's tolerance to each treatment.Patients with at least five actinic keratosis lesions on the face and scalp were selected. The patients were randomized to receive treatment with PDT with methyl aminolaevulinate or treatment with imiquimod. Tolerance, satisfaction and predisposition to repeat the treatment were evaluated.Most patients exhibited good or acceptable tolerance to both PDT and imiquimod treatment. There was a higher percentage of patients treated with PDT (93%) who were very satisfied compared with imiquimod (62%) (P=0·004). Most patients treated with either one of the two options would repeat the same treatment. No significant relationship was found between age, sex, working time exposed to the sun, phototype and hair colour and the tolerance to both treatments.Both PDT and imiquimod are treatments that are generally well tolerated. While both treatments provide a high level of satisfaction, PDT appears to be slightly superior in this regard.
Lesson of the Week: False localising signs in the spinal cord
Authors: D R S Jamieson, E Teasdale, H J Willison
Journal: BMJ (1996)

Acute spinal cord compression is an emergency where irreversible neurological damage can occur within hours. The diagnosis should be considered in any patient with an acute paraparesis, parasthesiae, or urinary retention, but there is commonly a delay because neurological examination is incompletely performed or the urgency of the condition is not appreciated. In the days of myelography the whole spinal axis up to the foramen magnum was routinely examined, but nowadays the use of more sophisticated imaging may miss the lesion because of the tendency to restrict the imaged field to the likely clinical site. If the signs are falsely localising there is a danger of missing a treatable cause. We describe a case where the sensory level localised the lesion 11 cord segments distal to the abnormality, leading to a serious delay in diagnosis.

Normal radiological examination at the clinical site of a cord lesion should prompt investigation at higher levels

### Case report

A 68 year old right handed retired joiner was admitted with acute retention of urine. There had been no prostatic symptoms and no constipation. Three weeks earlier he had developed numbness on the anterior aspects of his thighs. In the initial examination he was reported to have Medical Research Council grade 4 power globally in the legs with normal tendon reflexes and plantar responses. There was impairment of pinprick sensation bilaterally below the inguinal ligament with sacral sparing. Rectal examination and chest x ray examination were normal.

Two days later he was unable to stand and he was transferred as a neurosurgical emergency with a provisional diagnosis of an …
The Future of Research in Multiple Sclerosis
Authors: Robert J. Fox, Richard A. Rudick
Journal: JAMA Neurology (2015)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Neurology HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Neurology journal
Transcription Factor Snail Regulates Tumor Necrosis Factor α–Mediated Synovial Fibroblast Activation in the Rheumatoid Joint
Authors: Shih‐Yao Chen, Ai‐Li Shiau, Yuan‐Tsung Li, Chi‐Chen Lin, I‐Ming Jou, Ming‐Fei Liu, Chao‐Liang Wu, Chrong‐Reen Wang
Journal: Arthritis & Rheumatology (2014)

Objective The transcription factor Snail is involved in various biologic functions. We hypothesized that this molecule regulates tumor necrosis factor α (TNFα)–mediated synovial fibroblast activation in the rheumatoid joint. The aim of this study was to examine the role of Snail in the expression of cadherin‐11 (Cad‐11) and myofibroblast markers, interleukin‐6 (IL‐6) production, and the invasive ability of cells. Methods Synovium samples were obtained from patients with rheumatoid arthritis (RA) and from rats with collagen‐induced arthritis (CIA). Synovial fibroblasts were treated with TNFα or a Wnt signaling inducer, and the joints of rats with CIA were injected with a TNFα antagonist. Modulation of Snail expression in the synovial fibroblasts and joints was performed by lentiviral vector–mediated transfer of complementary DNA or short hairpin RNA. Results The expression of Snail and Cad‐11 was higher in synovium and synovial fibroblasts from patients with RA compared with patients with osteoarthritis and was increased in rats with CIA. TNFα stimulation or activation of Wnt signaling up‐regulated the expression of Snail, Cad‐11, and α‐smooth muscle actin (α‐SMA) in synovial fibroblasts, and anti‐TNFα therapy down‐regulated the expression of Snail, Cad‐11, and α‐SMA in the joints of rats with CIA. Although synovial fibroblast transfectants in which Snail was overexpressed showed increased expression of Cad‐11 and α‐SMA and enhanced TNFα‐mediated invasive capacity and IL‐6 production, synovial fibroblast transfectants from rats with CIA in which Snail was silenced showed decreased expression and had the opposite effect on these functions. Normal joints in which Snail was overexpressed had hyperplastic synovium, with increased expression of Cad‐11, α‐SMA, and IL‐6. Silencing Snail expression ameliorated arthritis, with reduced Cad‐11 expression and reduced levels of extracellular matrix deposition in the joints of rats with CIA, whereas overexpression of Snail exacerbated arthritis, with increased Cad‐11 expression and increased levels of extracellular matrix deposition. Conclusion Our results demonstrate that Snail regulates TNFα‐mediated activation of synovial fibroblasts in the rheumatoid joint. These findings may contribute to the pharmacologic development of therapeutics targeting synovial fibroblasts in patients with RA.
Double-negative (CD4- CD8-) T cells from adult T-cell leukemia patients also have poor expression of the T-cell receptor alpha beta/CD3 complex
Authors: H Suzushima, N Asou, S Nishimura, K Nishikawa, JX Wang, T Okubo, M Naito, T Hattori, K Takatsuki
Journal: Blood (1993)
A memorable patient: An elderly man with flushing
Authors: H. Engel
Journal: BMJ (2002)

An old friend aged 78 occasionally complained that he had attacks of flushing, often after quite small amounts of alcohol. He had no other complaints, so I, in my ignorance, made light of it, with a joke about the “male menopause,” and thought no more about it. He was a fit man, apart from fairly well controlled hypertension, who had …
Abstract 13233: Does Fetal Aortic Valvuloplasty alter the Natural History of Aortic Stenosis?
Authors: Alexander Kovacevic, Mats Mellander, Gerald Tulzer, Ulrike Herberg, Joanna Dangel, Annika Öhman, Helena Gardiner
Journal: Circulation (2014)

Introduction: Fetal aortic valvuloplasty (FV) is proposed as therapy to achieve biventricular circulation (BV) in fetuses where univentricular circulation (UV) is likely. Hypothesis: FV cannot alter natural history (NH) outcome. Methods: Hybrid of case-control and repeated samples cohort study. Fetuses with aortic stenosis (AS) were enrolled in a multicenter study (2005-2012). FV was considered in 70 / 214 AS and successful in 59/67 (88.0%) performed. Six salvage cases (hydrops) were excluded and 47 liveborn FV could be matched with 95 controls (NH) by scan closest to 23 +/- 3 weeks and +/- 1 Z-score for MV, LV and AV, producing a best match group for each. Results: Procedure-related death occurred in 7/67 (10.4%). Overall 151/214 (71%) were liveborn, but outcome unknown in 5. Serial left sided growth was similar in FV and NH: Z score differences MV = 0.11, LV = 0.08, AV = 0.11, p&gt;0.90. Hazard ratio for FV survival was similar to NH at 30 d, 1 and 4 yrs after birth [0.68 (95% CI 0.347 - 1.315), p= 0.25]. Cohorts matched for MV, LV and AV did not show survival advantage after FV and survival with freedom from UV circulation showed fewer BV survivors in FV than NH. (Fig 1) Funnel plots show improved BV survival by center volume for FV, but more BV-UV conversions in one with limited surgical options where 17% vs 82% FV remain BV. (Fig 2) Conclusions: Data show no survival advantage or improved chance of BV at 4 years in fetuses matched for morphology at 23 wks undergoing FV. Centralization of FV may improve survival, but BV - UV conversion suggests a specialized surgical approach is also essential to maintain BV outcome. A carefully designed prospective study is indicated to better evaluate FV. procedure.
Erratum: Corrigendum: Sarcolipin is a newly identified regulator of muscle-based thermogenesis in mammals
Authors: Naresh C Bal, Santosh K Maurya, Danesh H Sopariwala, Sanjaya K Sahoo, Subash C Gupta, Sana A Shaikh, Meghna Pant, Leslie A Rowland, Sanjeewa A Goonasekera, Jeffery D Molkentin, Muthu Periasamy
Journal: Nature Medicine (2012)
Symmetrical ventricular hypertrophy.
Authors: J E Val-Mejias
Journal: Circulation (1978)

To the Editor:Recently Udall and Ellestad' reported the incidence and predic- tive implications of ventricular premature contractions associated with treadmill study.A population of 6500 patients stress tested was described with none lost to follow-up.However, if all patients are totalled in table 1 (1067 + 758 + 609 + 569) one arrives at a total of 3003 patients.What happened to the other 3497 patients, since none were lost to follow-up and the normals (negative TSTs and no VPCs) numbered only 1067 in table 1?The true total number of patients sampled is of some importance, because the authors add the patients with VPCs (758 + 569) to obtain 1327, and then divide by 6500 (or should 3003 be used?) to report a 20% prevalence of VPCs before, during, or after exercise in the first sentence of their results.
Squamous cell carcinoma in a child with Clericuzio-type poikiloderma with neutropenia
Authors: W. Rodgers, P. Ancliff, C.P. Ponting, L. Sanchez-Pulido, S. Burns, M. Hayman, V. Kimonis, N. Sebire, N. Bulstrode, J.I. Harper
Journal: British Journal of Dermatology (2012)

Fig S1. Left: Characteristic facies showing midface hypoplasia; also note poikiloderma with prominent pigmentary changes. Right: Preoperative image of the nonhealing ulcer of the right fourth toe. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
Increasing Prevalence of Knee Pain and Symptomatic Knee Osteoarthritis
Authors: Uyen-Sa D. T. Nguyen, Yuqing Zhang, Yanyan Zhu, Jingbo Niu, Bin Zhang, Piran Aliabadi, David T. Felson
Journal: Annals of Internal Medicine (2011)

Background
Recent surge in knee replacements has been assumed to be due to aging and increased obesity of the US population.