tbuckley/cabot-search huggingface dataset:
Abstract 4874: Epigenetic gene silencing is co-regulated by DNMT3B and polycomb-mediated histone modifications in human cancer
Authors: Bilian Jin, Keith D. Robertson
Journal: Cancer Research (2010)

Abstract CpG-cytosine methylation, the only epigenetic modification in mammalian DNA, is established and maintained by three DNA methyltransferases (DNMT): DNMT1, DNMT3A, and DNMT3B. Although essential for development and differentiation, DNA methylation patterns are frequently disrupted in cancer and contribute directly to carcinogenesis. Recent studies linking polycomb group (PcG) repression complexes (PRC1 and PRC2) to the DNMTs have begun to shed light on how methylation is targeted. By comparing genes regulated by DNMT3B, which we identified in previous studies, with known polycomb group target genes, we chose a panel of genes co-regulated by DNMT3B and PRC1/PRC2 to test whether these criteria (DNMT &amp; PcG co-regulation) could accurately identify novel targets of epigenetic silencing in human colon cancer. Using reverse transcription-PCR, bisulfite genomic sequencing, and pyrosequencing, we show that the majority of these genes are frequently silenced in colorectal cancer cell lines and primary tumors. We then analyzed the histone code, DNMT, and PRC1/PRC2 binding by chromatin immunoprecipitation at epigenetically silenced loci to reveal a novel link between DNMT3B and PRC1, which was further confirmed by siRNA knockdown assays. Specifically, loss of DNMT3B resulted in significant reductions in ubiquitinated histone H2A levels, a mark catalyzed by the RING2 subunit of PRC1. Taken together, these studies suggest that patterns of epigenetic modifiers and the histone code influence the propensity of a gene to become hypermethylated in cancer and that DNMT3B plays an important role in regulating PRC1 function. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 101st Annual Meeting of the American Association for Cancer Research; 2010 Apr 17-21; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2010;70(8 Suppl):Abstract nr 4874.
History of Inuit Community Exposure to Lead, Cadmium, and Mercury in Sewage Lake Sediments
Authors: Mark H. Hermanson, James R. Brozowski
Journal: Environmental Health Perspectives (2005)

Exposure to lead, cadmium, and mercury is known to be high in many arctic Inuit communities. These metals are emitted from industrial and urban sources, are distributed by long-range atmospheric transport to remote regions, and are found in Inuit country foods. Current community exposure to these metals can be measured in food, but feces and urine are also excellent indicators of total exposure from ingestion and inhalation because a high percentage of each metal is excreted. Bulk domestic sewage or its residue in a waste treatment system is a good substitute measure. Domestic waste treatment systems that accumulate metals in sediment provide an accurate historical record of changes in ingestion or inhalation. We collected sediment cores from an arctic lake used for facultative domestic sewage treatment to identify the history of community exposure to Pb, Cd, and Hg. Cores were dated and fluxes were measured for each metal. A nearby lake was sampled to measure combined background and atmospheric inputs, which were subtracted from sewage lake data. Pb, Cd, and Hg inputs from sewage grew rapidly after the onset of waste disposal in the late 1960s and exceeded the rate of population growth in the contributing community from 1970 to 1990. The daily per-person Pb input in 1990 (720,000 ng/person per day) exceeded the tolerable daily intake level. The Cd input (48,000 ng/person per day) and Hg input (19,000 ng/person per day) were below the respective TDI levels at the time.
A history questionnaire for dermatology out-patients
Authors: A.Y. FINLAY, R. MARKS
Journal: British Journal of Dermatology (1979)

A questionnaire has been devised to be completed by new patients at home before attending the dermatology clinic. We report our experience with this questionnaire and discuss the potential advantages of this system; these include increased detail and accuracy of history, standardization of information and easier availability of information at patients' follow-up. Previously used questionnaires and other similar methods of obtaining a self administered history are discussed.
Is emotional restraint a healthy response to adversity?
Authors: K. Ecclestone, B. L. Robinson, S. Wheeler
Journal: BMJ (2014)

<b>Kathryn Ecclestone</b> worries about inappropriate educational interventions that promote emotional openness and pathologise normal responses, but <b>Ben Robinson</b> and <b>Sarah Wheeler</b> point to evidence showing better outcomes in patients who have been encouraged to express what they are feeling
The Prevalence of Gallstone Disease in Very Old Institutionalized Persons
Authors: Jack Ratner
Journal: JAMA (1991)

We present the results of a study that was undertaken at a large geriatric nursing home to assess the prevalence of gallstone disease in very old institutionalized persons. One hundred seventeen residents underwent ultrasound examination of the gallbladder. Two thirds of 82 women and half of 35 men had gallstone disease. When stratified for age, 80% of women and men over the age of 90 years were positive for the disease. In summary, the prevalence of gallstone disease in our very old nursing home population was found to be unexpectedly high.
Abstract LB-80: ATRX loss refines the classification of anaplastic glioma and is a favorable prognostic marker.
Authors: Benedikt Wiestler, David Capper, Tim Holland-Letz, Andreas von Deimling, Stefan M. Pfister, Michael Platten, Michael Weller, Wolfgang Wick
Journal: Cancer Research (2013)

Abstract Mutation / loss of ATRX expression has been described in anaplastic gliomas. The present study explored the role for ATRX status in the molecular classification of anaplastic gliomas and the impact of ATRX status on survival in the biomarker cohort of the NOA-04 trial. Patients (n=123) of the NOA-04 trial were analyzed for ATRX expression using immunohistochemistry. ATRX status was correlated with age, reference histology, IDH, 1p/19q and MGMT status, and the efficacy endpoints of the NOA-04 trial. Loss of ATRX expression was detected in 42% of anaplastic astrocytomas, 24% of anaplastic oligoastrocytomas and 10% of anaplastic oligodendrogliomas. It was restricted to IDH mutated tumors and almost mutually exclusive with 1p/19q co-deletion. Anaplastic oligoastrocytoma harboring ATRX loss shared a similar clinical course with anaplastic astrocytoma. Survival analysis showed a separation of IDH mutant tumors into two groups based on ATRX status: Tumors with ATRX loss have a significantly better prognosis (median time to treatment failure 1758 days [95% CI 1316 days - to not reached] vs. 968 days [95% CI 496 days - to not reached], log rank test, p = 0.0044). Independent of histological subtype, patients whose tumors harbored ATRX loss had a longer overall survival when initially treated with radiotherapy rather than with chemotherapy (p = 0.03). ATRX status helps to re-classify oligoastrocytomas, since ATRX loss is a hallmark of astrocytic tumors. Furthermore, ATRX loss defines a subgroup of tumors with a favorable prognosis and predicts benefit from radiotherapy. Citation Format: Benedikt Wiestler, David Capper, Tim Holland-Letz, Andreas von Deimling, Stefan M. Pfister, Michael Platten, Michael Weller, Wolfgang Wick. ATRX loss refines the classification of anaplastic glioma and is a favorable prognostic marker. [abstract]. In: Proceedings of the 104th Annual Meeting of the American Association for Cancer Research; 2013 Apr 6-10; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2013;73(8 Suppl):Abstract nr LB-80. doi:10.1158/1538-7445.AM2013-LB-80
RADIAL ACCESS DURING PRIMARY ANGIOPLASTY IN ACUTE MYOCARDIAL INFARCTION. EXPERIENCE OF A UNIQUE CENTER IN SOUTHAMERICA
Authors: Luis A. Pérez, Eduardo Lecannelier, Reinaldo Venegas, Jorge Gajardo, Alvaro Saldaña, Jessica Parra, Virginia Segall, Isabel Robles
Journal: Journal of the American College of Cardiology (2010)
918-19 The Effect of Preprocedural Intracoronary Thrombus on Patient Outcome After Percutaneous Coronary Intervention
Authors: William B. Hillegass, E. Magnus Ohman, Mary Ann O’Hanesian, Robert A. Harrington, David P. Faxon, Donald F. Fortin, Stephen G. Ellis, Richard S. Stack, David R. Holmes, Robert M. Califf
Journal: Journal of the American College of Cardiology (1995)
Pattern of Sensitization of Tomato Seed Lipid Transfer Protein
Authors: Miguel González, Laura Martin-Pedraza, Maria Luisa Somoza, Natalia Blanca, Mayte Villalba, Cristobalina Mayorga, Gabriela Canto, Maria J. Torres, Ana Molina, Miguel Blanca
Journal: Journal of Allergy and Clinical Immunology (2015)
Interactive Effect of Eczema and Food Allergy on Asthma in Children
Authors: D.M. Caruso, L.M. Arguelles, J.S. Kim, R. Gupta, A. Schroeder, K.E. Meyer, Y. Vucic, B. Rowland, E. Frankis, J. Costello
Journal: Journal of Allergy and Clinical Immunology (2009)
Use of the Curved Linear-Array Echo Endoscope to Identify Gastrorenal Shunts in Patients with Gastric Fundal Varices
Authors: H. Kakutani, S. Hino, K. Ikeda, T. Mashiko, K. Sumiyama, Y. Uchiyama, A. Kuramochi, Y. Kitamura, K. Matsuda, M. Kawamura, H. Tajiri, M. Urashima
Journal: Endoscopy (2004)

: Balloon-occluded retrograde transvenous obliteration (B-RTO) has emerged as an effective, minimally invasive treatment for fundal varices. B-RTO requires a spontaneously developed gastrorenal shunt as a pathway for the balloon catheter to reach the fundal varices. We used a curved linear-array (CLA) echo endoscope in patients with fundal varices to identify gastrorenal shunts, and compared the detection rate with the gold standard, contrast-enhanced computed tomography (CECT).A total of 40 patients with fundal varices were examined with both CLA echo endoscopy and CECT. The CECT images were retrospectively and independently evaluated by two gastroenterologists who were unaware of the clinical details, including the results of the CLA echo endoscopy.CLA echo endoscopy identified gastrorenal shunts in 26/40 patients with fundal varices. It visualized the shunt in a longitudinal direction and provided images of the connections of the shunt at both ends, the fundal varices and the left renal vein/branch of the inferior adrenal vein. The kappa index for CLA echo endoscopy and CECT for the identification of gastrorenal shunt was 0.9 (95 % CI, 0.6 to 1.0). When the cutoff point for the diameter of the gastrorenal shunt detected by the CLA echo endoscope was set at equal to or greater than 5 mm, the kappa index was 1.0 (95 % CI, 0.7 to 1.0).These results suggest that CLA echo endoscopy can successfully identify gastrorenal shunt and provide detailed morphological information. It also efficiently identifies patients suitable for B-RTO, particularly in cases of acute bleeding. It also has considerable potential for providing detailed information with regard to the treatment of gastric varices.
Public should be told that vaccines may have long term adverse effects
Authors: J. B. Classen, D. C Classen
Journal: BMJ (1999)

Thank you for your interest in spreading the word about The BMJ.NOTE: We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail. We do not capture any email address. Username * Your Email * Send To * You are going to email the following Public should be told that vaccines may have long term adverse effects Your Personal Message CAPTCHA This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
Increased Cardiovascular Morbidity and Mortality in Type 2 Diabetes Is Associated With the Glutathione S Transferase Theta–Null Genotype
Authors: Alex S.F. Doney, Simon Lee, Graham P. Leese, Andrew D. Morris, Colin N.A. Palmer
Journal: Circulation (2005)

Glutathione S-transferases (GSTs) modulate oxidative stress, and variation in GST genes has been associated with cardiovascular disease risk. We prospectively determined smoking-related cardiovascular morbidity by GST genotype in a large cohort of individuals with type 2 diabetes using a population-based diabetes research database (DARTS).We performed a cohort study of 2015 individuals with type 2 diabetes. Individuals were genotyped for the Ile105Val variant of GSTP1 and the deleted variants of GSTT1 and GSTM1. Clinical characteristics, smoking status, and incidence of subsequent cardiovascular events were obtained by examining the DARTS databases. Variation in the GSTP1 and GSTM1 genes was not associated with smoking-related risk of death or cardiovascular events. There was an increase in the rate of cardiovascular events in smokers lacking the GSTT1 gene compared with smokers with the GSTT1 gene intact (hazard ratio [HR], 1.96; P=0.001). This excess of cardiovascular events was due to both strokes (HR, 2.7; P=0.008) and myocardial infarctions (HR, 1.9; P=0.006). The rate of death as a result of a cardiovascular event was even more markedly increased in the GSTT1-null smokers (HR, 2.7; P=0.001), with a 2-fold increase in myocardial infarction fatality ratio. These effects translated into an increase in overall death and a decrease in age at death. We also found that the GSTT1- genotype was associated with progression of both diabetic retinopathy and nephropathy (P=0.005 and P=0.01, respectively), although we found little evidence for an interaction with smoking.Genetic absence of the GSTT1 enzyme is an independent and powerful predictor of premature vascular morbidity and death in individuals with type 2 diabetes.
Behind every great woman
Authors: T. Greenhalgh
Journal: BMJ (2000)

What I want for Christmas more than anything else is a wife. I'm only interested in the old fashioned sort, who would stay at home most of the time baking scones and ironing. If anyone's interested, here's the job description:

1.  Get up a few minutes before me, grind beans, and put coffee on. Tidy up kitchen and place any half abandoned piles of paper neatly …
A randomized trial of cyclosporine in steroid-resistant idiopathic nephrotic syndrome
Authors: Claudio Ponticelli, Gianfranco Rizzoni, Alberto Edefonti, Paolo Altieri, Emilio Rivolta, Stefano Rinaldi, Luciana Ghio, Egidio Lusvarghi, Rosanna Gusmano, Francesco Locatelli, Sonia Pasquali, Alfonso Castellani, Ornella Della Casa-Alberighi
Journal: Kidney International (1993)
Global atmospheric changes.
Authors: W T Piver
Journal: Environmental Health Perspectives (1991)

Increasing concentrations of CO2 and other greenhouse gases in the atmosphere can be directly related to global warming. In terms of human health, because a major cause of increasing atmospheric concentrations of CO2 is the increased combustion of fossil fuels, global warming also may result in increases in air pollutants, acid deposition, and exposure to ultraviolet (UV) radiation. To understand better the impacts of global warming phenomena on human health, this review emphasizes the processes that are responsible for the greenhouse effect, air pollution, acid deposition, and increased exposure to UV radiation.
Management of Cholelithiasis-Reply
Authors: Rama P. Venu
Journal: JAMA (1984)

In Reply.—  The case reported by Dr McKenzie is of a 24-year-old woman who had recurrent biliary colic secondary to choledocholithiasis that could only be diagnosed by laparotomy. Although our article dealt with gallbladder stones diagnosed only by ERCP, the clinical situation described by Dr McKenzie is similar to the problem that we have dealt with.  Based on our experience on the usefulness of ERCP in demonstrating small stones in the common bile duct, we would like to reemphasize that roentgenographic technique and the concentration of the contrast material used are extremely important because small stones could easily be missed.  We disagree with Dr McKenzie in recommending exploratory laparotomy for patients with biliary colic as a diagnostic and therapeutic approach. This is supported by our small but incomplete data on two of the seven patients (group 1) who had no stones detected by ERCP examination and who underwent exploratory laparotomy
Is recommended for severe accidental hypothermia
Authors: L. Gordon, G. J. Peek, J. A. Ellerton
Journal: BMJ (2010)

Gaffney and colleagues provide a useful overview of extracorporeal life support but fail to mention one important area—the rewarming of patients with severe accidental hypothermia accompanied by apnoea and cardiac arrest.1 Many reports describe the successful use of cardiopulmonary bypass, extracorporeal membrane oxygenation (ECMO), and …
Peripheral-blood-based PCR assay to identify patients with active pulmonary tuberculosis
Authors: R Condos, A McClune, W.N Rom, N.W Schluger
Journal: The Lancet (1996)

Summary Background There is a need for rapid diagnosis of pulmonary tuberculosis. We have previously used a PCR to detect circulating Mycobacterium tuberculosis DNA in blood samples from patients (mostly HIV-infected) with pulmonary tuberculosis. We have now prospectively investigated the role of this blood-based PCR assay for diagnosis of this disease in a clinical setting. Methods Our PCR assay is specific for the IS6110 insertion element of the M tuberculosis complex of organisms. We used it to test peripheral blood from 88 consecutive patients admitted to a chest ward with suspected pulmonary tuberculosis. Personnel who carried out the assay did not know the results of any clinical investigations and ultimate diagnosis, and clinicians did not know the PCR results. Results of the PCR assay were compared with the final clinical diagnosis. A subgroup of 15 patients had blood samples assayed serially to track the PCR signal over time. Findings 41 patients had a final clinical diagnosis of tuberculosis, and the cases were typical of those seen at our hospital: HIV infection was common, and most cases were not sputum-smear positive for acid-fast bacilli. The PCR assay correctly identified 39 of 41 patients with proven pulmonary tuberculosis, 26 (63%) of whom were sputum-smear negative. There were five patients in whom a positive PCR result did not accord with the final clinical diagnosis, and two of the 44 negative PCR results were classified as false negatives. The overall sensitivity and specificity of the PCR assay for a diagnosis of tuberculosis was 95% and 89%, respectively. In 15 patients with pulmonary tuberculosis and a positive blood assay, the PCR result remained positive after 1 month of therapy, but had reverted to negative in 13 of the 15 by 4 months of therapy. Interpretation We conclude that peripheral-blood-based PCR detection for the diagnosis of tuberculosis is a technically feasible approach that has a potentially important role in the diagnosis of pulmonary tuberculosis.
Induction of oxidative stress by oxidized LDL via meprinα-activated epidermal growth factor receptor in macrophages
Authors: Pan Gao, Xiao-mei Wang, Dei-hui Qian, Ze-Xue Qin, Jun Jin, Qiang Xu, Qiao-Ying Yuan, Xue-Jun Li, Liang-Yi Si
Journal: Cardiovascular Research (2012)

AimsThe aim of this study was to explore meprinα-mediated transactivation of the epidermal growth factor receptor (EGFR) and reactive oxygen species (ROS) production in macrophages.
Coagulation factor IX: Successful surgical experience with a purified factor IX concentrate
Authors: Jonathan C. Goldsmith, Carol K. Kasper, Philip M. Blatt, Edward D. Gomperts, Craig M. Kessler, Arthur R. Thompson, Steve W. Herring, Patricia L. Novak
Journal: American Journal of Hematology (1992)

Abstract The use of plasma‐derived coagulation factor concentrates has been marked by the transmission of viral agents. Infusions of factor IX complex concentrates have been additionally complicated by inappropriate thrombosis. Use of these concentrates in the neonate, in those with liver disease, and in surgical patients results in increased risk for this complication. Twenty patients have been infused with a purified coagulation factor IX concentrate for fall‐off and recovery studies. A two‐compartment model indicated an initial phase half‐life of 4.06 ± 2.86 hr and a β phase half‐life of 20.0 ± 3.8 hr following the administration of AlphaNine®, Coagulation Factor IX (Human). In vivo recovery was 62.7% ± 13.8%, with an average factor IX coagulant level of 73% ± 16% at 15 min after the infusion of a mean dose of 45 U/kg. Thirteen previously transfused patients with hemophilia B underwent major orthopedic or general or dental surgery using this purified factor IX. Operative outcomes were excellent in all patients. No excessive bleeding was noted. There was no laboratory or clinical evidence for a disseminated intravascular coagulopathy. The excellent surgical outcomes observed in this multitransfused group with biochemical evidence for active liver disease demonstrates the utility and safety of a purified coagulation factor IX concentrate. © 1992 Wiley‐Liss, Inc.
Dynamic Lymphoscintigraphy in Intermediate Thickness Melanoma: Results of our First 100 Patients.
Authors: J S Kempf, A P Yudd, J Goydos, M Kozaczek, D Landsnes
Journal: Clinical Nuclear Medicine (1999)

Scientific Abstracts And Posters From The 44Th Annual Meeting Of The Southwestern Chapter Of The Society Of Nuclear Medicine, And From The 12Th Northeastern Regional Scientific Meeting Of The New England And New York Chapters Of The Society Of Nuclear Medicine
The Precautionary Principle and Risk Perception: Experimental Studies in the EMF Area
Authors: Peter M. Wiedemann, Holger Schütz
Journal: Environmental Health Perspectives (2005)

Possible adverse health effects due to electromagnetic fields (EMFs) from cellular phones and base stations present a major public health issue across Europe. Because scientists cannot exclude that EMFs may cause health problems, the application of the precautionary principle is debated heavily. By considering precautionary measures, political decision makers hope to cope with public fears about EMFs. We present results from two experimental studies that indicate that precautionary measures may trigger concerns, amplify EMF-related risk perceptions, and lower trust in public health protection. Such impacts, questioning common expectations, should be considered in decisions about precautionary measures.
Fundamentals of Radiology
Authors: Ronald D. Harris
Journal: JAMA (1983)

Almost any book by Lucy Squire is worth reading, especially if you are a medical student or someone interested in an introduction to the various phases of general radiology. This book has been required introductory reading in many, if not all, training programs in radiology and as an introduction to radiology for medical students for many years. Dr Squire's writing style is delightful, and the information comes across in a straightforward and entertaining manner. In her discussion of any particular topic, she frequently incorporates appropriate bits of interesting medical history along the way for further enlightenment of the reader. There are also short self-motivated quizzes to test the reader's analytical abilities and powers of observation and recall. (The answers are in the back of the book.) The book is quite well illustrated, and since it is published on good-quality paper, the pictures of the x-ray images reproduce very well. This