SHUNT ENCEPHALOMYELOPATHY. I. RECURRENT PROTEIN ENCEPHALOPATHY WITH RESPONSE TO ARGININE
Authors: L ZIEVE, D F MENDELSON, M GOEPFERT
Journal: Annals of Internal Medicine (1960)

Article1 July 1960SHUNT ENCEPHALOMYELOPATHY. I. RECURRENT PROTEIN ENCEPHALOPATHY WITH RESPONSE TO ARGININELESLIE ZIEVE, M.D., F.A.C.P., DAVID F. MENDELSON, M.D., MARY GOEPFERT, M.D.LESLIE ZIEVE, M.D., F.A.C.P.Search for more papers by this author, DAVID F. MENDELSON, M.D.Search for more papers by this author, MARY GOEPFERT, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-53-1-33 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe neuropsychiatric complications of spontaneous or surgically induced portal-systemic shunts have been widely observed and extensively discussed, so the most frequent clinical patterns are now common knowledge. Various more obscure and infrequent but no less fascinating manifestations of these complications are becoming evident as our awareness of the clinical entity increases. Two such manifestations have been observed in patients described in this report. The first is the occurrence of extreme and progressive protein intolerance, with correction of the recurrent toxic states by large doses of arginine. The second, elaborated upon in the companion paper that follows, is the occurrence of...Bibliography1. SummerskillDavidsonSherlockSteiner WHEASRE: The neuropsychiatric syndrome associated with hepatic cirrhosis and an extensive portal colateral circulation, Quart. J. Med. 25: 245, 1956. MedlineGoogle Scholar2. ZieveHillBuddAnderson LEJWE: Unpublished observations on hepatic coma. Google Scholar3. NajarianHarper JSHA: A clinical study of the effect of arginine on blood ammonia, Am. J. Med. 21: 832, 1956. CrossrefMedlineGoogle Scholar4. NajarianHarperMcCorkle JSHAHJ: The diagnosis and clinical management of hepatic coma in surgical patients, Am. J. Surg. 96: 172, 1958. CrossrefMedlineGoogle Scholar5. NajarianHarperMcCorkle JSHAHJ: Amino acid therapy of ammonia intoxication, Surgery 44: 11, 1958. MedlineGoogle Scholar6. FaheyNathansRairigh JLDD: Effect of l-arginine on elevated blood ammonia levels in man, Am. J. Med. 23: 860, 1957. CrossrefMedlineGoogle Scholar7. FazekasTicktinShea JFHEJG: Effects of l-arginine on hepatic encephalopathy, Am. J. M. Sc. 234: 462, 1957. CrossrefMedlineGoogle Scholar8. WolfeFastStormontDavidson SJBBJMCS: Treatment of hepatic coma: use of certain Krebs' urea cycle intermediates (l-arginine, dl-ornithine), J. Lab. and Clin. Med. 51: 672, 1958. MedlineGoogle Scholar9. ReynoldsRedekerDavis TBAGP: A controlled study of the effects of l-arginine on hepatic encephalopathy, Am. J. Med. 25: 359, 1959. CrossrefGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Minneapolis, Minnesota*Received for publication October 14, 1959.From the Departments of Medicine and Neurology and the Radioisotope Service, Veterans Administration Hospital, University of Minnesota, Minneapolis, Minnesota.†Present address: St. Louis University School of Medicine.Requests for reprints should be addressed to Leslie Zieve, M.D., Veterans Administration Hospital, Minneapolis 17, Minnesota. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byAlcoholic Myelopathy and Nutritional DeficiencyUse of model for end-stage liver disease exception points for early liver transplantation and successful reversal of hepatic myelopathy with a review of the literatureCorticospinal involvement in patients with a portosystemic shunt due to liver cirrhosisPortosystemic myelopathy: Spastic paraparesis after portosystemic shuntingHepatic myelopathy Case report with review of the literatureEffects of ornithine aspartate on plasma ammonia and plasma amino acids in patients with cirrhosis. A double-blind, randomized study using a four-fold crossover designAcute Fragility of Cerebral Blood Vessels in Hepatic ComaMYELOPATHY IN HEPATIC DISEASE AND PORTOSYSTEMIC VENOUS ANASTOMOSISPortal HypertensionLaboratory notes 1 July 1960Volume 53, Issue 1Page: 33-52KeywordsArginineBrain diseasesCirrhosisComaHospital medicineNeurologyProteinsResearch laboratories ePublished: 1 December 2008 Issue Published: 1 July 1960 PDF downloadLoading ...