tbuckley/cabot-search huggingface dataset:
The storehouse/correspondence partition in memory research: Promises and perils
Authors: Arie W. Kruglanski
Journal: Behavioral and Brain Sciences (1996)

Abstract The novel correspondence metaphor outlined by Koriat &amp; Goldsmith offers important advantages for studying critical issues of memory-accuracy. It also fits well with the current emphasis on the reconstructive nature of memory and on the role of cognitive, metacognitive, and motivational factors in memory performance. These positive features notwithstanding, the storehouse/correspondence framework faces potential perils having to do with its implied linkage to the laboratory/real-life controversy and its proposal of studying correspondence issues in isolation from memory phenomena captured by the storehouse paradigm.
Abuse of Pregnant Women and Adverse Birth Outcome
Authors: Eli H. Newberger
Journal: JAMA (1992)

ABUSE of pregnant women is not rare. The prevalence of physical assault of women during pregnancy has been estimated at 8% in a random sample drawn from public and private prenatal clinics,<sup>1</sup>and between 7% and 11% in nonrandom samples drawn from university obstetric clinic services.<sup>2,3</sup>Rates of overall violence against pregnant women gathered by the Second National Family Violence Survey<sup>4</sup>were as follows: 154 acts of violence per 1000 during the first 4 months of pregnancy and 170 acts of violence per 1000 women during the fifth through ninth months. (Pregnant women's risk of what was characterized as "abusive violence" was 60.6% greater than that of nonpregnant women in this national probability sample of 6002 households, but this was interpreted as an artifact of age because women under 25 years of age were more likely both to be pregnant and to be abused by husbands and
A case of chronic paraffin pneumonitis
Authors: R. Salm, E. W. Hughes
Journal: Thorax (1970)

A case of chronic paraffin pneumonitis is reported which had remained undiagnosed during life. The patient, a woman aged 48 at death, was subsequently found to have been taking regularly very large doses of liquid paraffin during a decade or more. The main clinical, radiological and histological features are discussed.
The Risk of Cesarean Delivery with Neuraxial Analgesia Given Early versus Late in Labor
Authors: Cynthia A. Wong, Barbara M. Scavone, Alan M. Peaceman, Robert J. McCarthy, John T. Sullivan, Nathaniel T. Diaz, Edward Yaghmour, R-Jay L. Marcus, Saadia S. Sherwani, Michelle T. Sproviero, Meltem Yilmaz, Roshani Patel, Carmen Robles, Sharon Grouper
Journal: New England Journal of Medicine (2005)

Epidural analgesia initiated early in labor (when the cervix is less than 4.0 cm dilated) has been associated with an increased risk of cesarean delivery. It is unclear, however, whether this increase in risk is due to the analgesia or is attributable to other factors.
The Relative Frequency of the Hurler and Hunter Syndromes
Authors: Victor A. McKusick
Journal: New England Journal of Medicine (1970)

DURING the past academic year, in connection with their course in genetics, our medical students were provided with a study guide consisting mainly of questions and problems, together with answers, for use with the textbook1 as a self-teaching device. One of the questions in the study guide stimulated so much discussion (and initially disagreement) among those involved in teaching this part of the course,† and the answer is of sufficient interest in connection with certain disorders that are currently receiving renewed investigative attention,2 3 4 5 6 7 that I chose to share it more widely with colleagues.The question was as follows: Question 7.3 . . .
Anorexia Nervosa in Male Subjects
Authors: P.J.V. Beumont
Journal: Psychotherapy and Psychosomatics (1970)

The term anorexia nervosa does not indicate merely weight loss in association with psychiatric disturbance but rather it designates a syndrome with distinctive characteristics. The author reports the case histories of six young male patients who fulfilled the rather stringent criteria needed for the diagnosis of anorexia nervosa and reports on estimations of urinary testosterone and of gonadotrophins which were undertaken in order to find an equivalent in the male of the menstrual disturbance which is such a prominent feature of the syndrome in females. The conclusions reached are that anorexia nervosa does undoubtedly occur in males, that these subject do show a disturbance in their sex hormones while they are emaciated, but that the precise nature of this endocrine disturbance remains to be clarified.
Abstract 3304: Hyaluronan mediates interactions between CD44+ MSCs and CD34+ fibrocytes in Desmoid Tumors.
Authors: Hira Rizvi, Adelaide M. Carothers, Monica M. Bertagnolli, Nancy L. Cho
Journal: Cancer Research (2012)

Abstract We reported that 16/16 sporadic and familial desmoid tumors (DTs) contained CD44+CD73+CD90+Bmi1+ mesenchymal stromal cells (MSCs) and CD34+CD105+ALK1+ monocyte-derived fibrocytes. Hematopoietic stem cells (HSCs) and MSCs reside in the same bone marrow niche, and MSCs regulate HSC progenitor release into the circulation. Numerous signaling pathways maintain chemotactic and physical crosstalk between these types of stem cells (c-Kit/SCF, CXCR4/SDF-1, Notch/Jagged1, etc). HSC and MSC progenitors are both recruited to sites of tissue injury to aid in wound healing. We were interested to learn what crosstalk engages these multipotent cells in DTs. Hyaluronan (HA) is a long charged chain of repeating glucuronate and N-acteylglucosamine disaccharides that is synthesized by HA synthases (HAS 1, 2, 3) and degraded by hyaluronidases (HYAL1, 2). HA binds to receptors CD44, TLR2/4 and Hyaluronan binding protein (HABP). Immunofluorescent histochemistry was performed on our tumor collection to determine the expression of both metabolic and catabolic HA enzymes. All of our DTs contained cells expressing HA, HYAL2, HAS2, and HABP2. HABP2 attenuates hyaluronan-receptor interactions. Double staining showed that all MSCs expressed HA and HAS2, confirming the functional significance of the CD44+ receptor in these cells. The majority of MSCs co-expressed HABP2. CD34+ fibrocytes but not CD44+ MSCs co-expressed HYAL2. CD44 expression by MSCs is stimulated by PDGF-BB, and in DTs, CD44+ MSCs co-expressed PDGFRα. These results suggest that paracrine regulation of HA signaling in these tumors may be another way in which MSCs and fibrocytes crosstalk. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 103rd Annual Meeting of the American Association for Cancer Research; 2012 Mar 31-Apr 4; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2012;72(8 Suppl):Abstract nr 3304. doi:1538-7445.AM2012-3304
Clinical importance of enteric communication with abdominal abscesses.
Authors: S H Saverymuttu, A M Peters, J P Lavender
Journal: BMJ (1985)

The dynamics of leucocytes in abdominal abscesses were studied using indium-111 autologous leucocyte scanning in 30 patients. Thirteen patients showing enteric drainage of leucocytes on delayed scans were characterised by a lack of abdominal localising signs and a low detection rate by ultrasound (25%). By contrast, 16 of 17 patients without enteric drainage had abdominal signs, and in these patients ultrasound was associated with a higher detection rate (58%). Despite the presence of an enteric route of drainage for the abscess 10 of the 13 patients needed surgical intervention. These results help explain the wide variation in clinical presentation of abdominal abscesses; suggest that 111In leucocyte scanning should be the initial investigation in those patients without focal signs; and show that formal surgical drainage is needed in patients recognised as having enteric communication with abscesses.
Principles of Anesthesiology
Authors: John R. Gordon
Journal: JAMA (1977)

The 1976 edition, like the previous one, is arranged in four sections covering fundamental practices, regional anesthesia, and physiological and pharmacological considerations. Of the 90 chapters, 12 are completely new, and four are amplified. The original 75 chapters remain with varying degrees of revision. The new topics are antiemetic drugs, vomiting and aspiration, drug interaction, fluids and electrolytes, acid-base balance, the kidney and anesthesia, drug effects in liver disease, oxygenation and resuscitation, dynamics and pharmacology of carbon dioxide, temperature regulation and heat problems, complications of spinal anesthesia, postoperative complications peculiar to spinal anesthesia, and acupuncture. A notable feature of the book continues to be its wealth of clear and informative illustrations borrowed from prominent, contemporary sources. The section on regional anesthesia is generous in scope and reasonably current. The chapter on hazards in anesthesia practice includes much useful information on environmental pollution in the operating room and presents modern material
TCT-175 Optimal Antiplatelet Regimen for Critical Limb Ischemia due to Pure Isolated Infrapopliteal Lesions
Authors: Junichi Tazaki, Keisuke Hirano, Osamu Iida, Daizo Kawasaki, Takeshi Kimura, Yusuke Miyashita, Yoshiaki Shintani, Yoshimitsu Soga, Nobuhiro Suematsu, Kenji Suzuki, Terutoshi Yamaoka, Yasutaka Yamauchi
Journal: Journal of the American College of Cardiology (2012)
Characterization of the lymphocyte membrane receptor for factor H (β1H- globulin) with an antibody to anti-factor H idiotype
Authors: JD Lambris, GD Ross
Journal: The Journal of Experimental Medicine (1982)

Antibody to the binding site (idiotype) of anti-factor H was shown to have specificity for both B lymphocyte membrane H receptors and C3b. Goat F(ab')(2) anti-human H was purified by absorption and elution from H agarose and used for rabbit immunization to produce anti-anti-H (aaH). After absorption with nonimmune goat IgG, (125)I-labeled aaH bound to B lymphocytes and to sheep erythrocytes coated with C3b (EC3b) but did not bind to T lymphocytes or to EC3d. All B cell- and C3b-specific activities of the aaH were removed and subsequently recovered by absorption and elution of the antibody from either C3-agarose or goat-anti-H-agarose. This indicated that the aaH probably recognized a single common antigenic structure that was shared by anti-H, C3b, and the membranes of B cells. Affinity-purified aaH resembled H in that it bound to B cells, blocked the uptake of H onto B cell H receptors, and triggered B cells to release endogenous factor I (C3b inactivator). In addition, aaH functioned with factor I as either a cofactor for cleavage of fluid-phase C3b or a potentiator for cleavage of bound C3b. This same spectrum of C3 binding functions could not be demonstrated with either sheep anti-C3b or rabbit-anti-C3c. Analysis by sodium dodecyl sulfate- polyacrylamide get electrophoresis of the [(3)H]leucine intrinsically labeled B cell proteins reactive with the purified aaH revealed proteins of 100,000 M(r) and 50,000 M(r) without reduction, and after complete reduction of disulfide bonds, a single protein band of 50,000 M(r). This same protein molecular weight profile was also demonstrated with labeled B cell proteins that were absorbed and eluted from H-agarose. Thus, aaH is apparently specific for both B cell H receptors and C3b. However, because parallel analysis of C3b confirmed its known 115,000- and 75,000-M(r) polypeptide chain structure, the H receptor is probably not C3b and shares only the structure of the H binding site with C3b.
Radiocontrol for general practitioners.
Authors: R. D. Haigh
Journal: BMJ (1969)

MWICALJoUWNALseen, a small hole had been made in the neck of the ampoule, the contents abstracted and replaced by water, and the inert and con- ta.ninated phial carefully put back in the rack, with the hole at the back, where it was virtually invisible.Fortunately, an astute staff nurse noticed this, and Methedrine has now been withdrawn from the racks.; ~~~~~... . . . . . . . .
THE THERAPY OF CALCIUM SULPHID IN INFLAMMATORY DISEASES OF THE AIR PASSAGES.
Authors: W. BAYARD SHIELDS
Journal: JAMA (1897)

My attention was first attracted to the therapeutical uses of calcium sulphid in inflammatory diseases of the air passages by an article which appeared in theJournal of the American Medical Association, April, 1892, written by Edward F. Wells of Chicago. Dr. Wells has been using this drug in tuberculosis for a number of years and claimed to have had good results in selected cases. He had antedated Burgeon's treatment of rectal injections of sulphuretted hydrogen gas by several years. It seems that his attention had first been called to this treatment by noticing that his tubercular patients who frequented sulphur springs improved more rapidly and uniformally than those going elsewhere. There seems to be no doubt in my mind that to a certain extent that this drug has a beneficial but not curative effect in tuberculosis, as my experience leads me to know that I have seen cases in
Bullets and Bacilli: The Spanish-American War and Military Medicine
Authors: E. McSweegan
Journal: JAMA (2004)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
'Transdermal' may travel to other drugs
Authors: Catherine Macek
Journal: JAMA (1983)

Transdermal is the catchword in a number of drug advertisements these days.  But delivery of medications by the transdermal route really is not a new concept, as a variety of drugs that are readily absorbed through the skin have been available in ointment form since the 1950s.  Certainly, for the right drug, transdermal delivery has several advantages over oral administration. It eliminates irregular gastric absorption as well as first pass inactivation by the liver. Moreover, constant absorption through the skin maintains relatively consistent blood levels of the drug. Yet the ointments present one major disadvantage: When applying them, it is difficult to achieve precise drug dosages.  This difficulty is largely eliminated by the new transdermal patches, in which a defined rate of drug release over a prescribed period of time is possible. The patches are worn on the chest or arm or behind the ear and dispense drugs for up
Iontophoretic delivery of dobutamine: An effective method to increase contractility of non-transmural infarcts
Authors: Boaz Avitall, John W. Hare, Cynthia S. Wilhelm, Raml Gal, Mohammad R. Jazayeri, Patrick J. Tchou, Jasbir S. Sra, Masood Akhtar
Journal: Journal of the American College of Cardiology (1991)
The Relationship Between Firearm Design and Firearm Violence
Authors: Garen J. Wintemute
Journal: JAMA (1996)

IN 1994, an estimated 39720 persons died from firearm-related injuries.<sup>1</sup>Firearms now rank a close second to motor vehicles as a cause of traumatic death nationwide. This convergence results not so much from an increase in the firearm-related death rate, which has remained relatively stable for the past 15 years, as from a steady decrease in the death rate from motor vehicle injuries.<sup>2</sup>That decrease stems in large part from an explicit focus on the contribution to motor vehicle death rates made by the design and marketing of motor vehicles themselves.<sup>3,4</sup>
Abstract 894: Targeting ROS1 receptor tyrosine kinase gene fusions in non-small cell lung cancer
Authors: Kurtis D. Davies, Anh T. Le, Margaret C. Skokan, Mariana F. Theodoro, Marileila Varella-Garcia, D. Ross Camidge, Robert C. Doebele
Journal: Cancer Research (2012)

Abstract Genomic rearrangements that fuse kinase domain-containing 3′ regions of tyrosine kinase genes with 5′ regions of unrelated genes are well characterized in cancer. The resulting fusion proteins often drive proliferation and invasion of tumor cells and thus represent attractive targets for therapeutic intervention. One such kinase that has been demonstrated to be involved in various genomic rearrangement events in non-small cell lung cancer (NSCLC), glioblastoma, and cholangiocarcinoma is the ROS1 receptor tyrosine kinase (also known as c-ROS and ROS). To date, three different 5′ fusion partners for ROS1 have been identified. In this study, we examined the frequency of ROS1 gene rearrangement in a panel of 428 patient-derived NSCLC tumor samples using a break-apart FISH assay. We found that approximately 1.2% of samples were positive. In positive samples, the expression of the fusion gene and the identity of the fusion partner were examined. HCC78 is a NSCLC cell line that has been demonstrated by us and others to express the SLC34A2-ROS1 gene fusion. In order to assess the cellular consequences of ROS1 inhibition, we treated HCC78 cells with two distinct small molecule kinase inhibitors that have activity against ROS1 (crizotinib and TAE684). We found that both drugs inhibited proliferation of HCC78 cells, down-regulated signaling pathways known to control cellular growth and survival, and disrupted normal cell-cycle progression. Finally, we report clinical data from a NSCLC patient with a ROS1 gene rearrangement, as detected by the FISH break-apart assay, who demonstrated tumor shrinkage when treated with crizotinib. This patient's tumor exhibited a novel ROS1 gene fusion partner. In conclusion, genomic rearrangements involving the ROS1 receptor tyrosine kinase are present in a small subset of NSCLC patients, and drugs that target ROS1 may be an effective treatment strategy for these patients. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 103rd Annual Meeting of the American Association for Cancer Research; 2012 Mar 31-Apr 4; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2012;72(8 Suppl):Abstract nr 894. doi:1538-7445.AM2012-894
Intravenous administration of the endothelin-1 antagonist BQ-123 does not ameliorate myocardial ischaemic injury following acute coronary artery occlusion in the dog
Authors: S. M Krause, J. J Lynch, I. I Stabilito, R. F Woltmann
Journal: Cardiovascular Research (1994)

Objective: It has been proposed that myocardial ischaemic injury is modulated in part by the release of endothelin-1 from the coronary endothelium either during ischaemia or following reperfusion. Release of sufficient amounts of endothelin-1 would result in coronary vasoconstriction and could potentiate ischaemic damage. An endothelin-1 antagonist. BQ-123, was given intravenously to evaluate the role of endothelin-1 in postischaemic injury and determine whether blockade of the ETA receptor would afford protection from ischaemia/reperfusion injury. Methods: Myocardial injury was induced in anaesthetised dogs using 90 min of left circumflex coronary artery occlusion followed by 4 h of reperfusion. Animals treated with a continuous intravenous infusion of BQ-123 (0.1 mg·kg−1·min−1). begun 10 min before ischaemia and continued throughout ischaemia and reperfusion, were compared to saline treated animals. Results: After 4 h of reperfusion the myocardial infarct size measured by triphenyltetrazolium chloride staining was not different between the two groups. Infarct size in the control group was 25.7(SEM 5.4)% of the area at risk while BQ-123 treatment resulted in an infarct size of 29.2(7.1)% of the area at risk (p = 0.70). Plasma endothelin-1 concentration measured at the coronary sinus was only significantly increased following 5 min of reperfusion. Conclusions: The intravenous administration of a specific ETA receptor antagonist does not protect against ischaemia/reperfusion injury. These results suggest that endothelin-1 receptor antagonists require access to the area at risk during occlusion to protect the myocardium from ischaemic injury. Cardiovascular Research 1994;28:1672-1678
Gene therapy for neurodegenerative disorders and malignant brain tumors
Authors: Lan Chiang, Eric P. Flores, Dennis Y. Wen, Walter A. Hall, Walter C. Low
Journal: Behavioral and Brain Sciences (1995)

Abstract Gene therapy approaches have great promise in the treatment of neurodegenerative disorders and malignant brain tumors. Neuwelt et al. review available viral-mediated gene therapy methods and their blood-brain-barrier (BBB) disruption delivery technique, briefly mentioning nonviral mediated gene therapy methods. This commentary discussed the BBB disruption delivery technique, viral and nonviral mediated gene therapy approaches to Parkinson's disease, and the potential use of antisense oligo to suppress malignant brain tumors.
Reform, Regulation, and Pharmaceuticals — The Kefauver–Harris Amendments at 50
Authors: Jeremy A. Greene, Scott H. Podolsky
Journal: New England Journal of Medicine (2012)

In 1962, President Kennedy signed into law the Kefauver–Harris Amendments to the Federal Food, Drug, and Cosmetic Act. Many issues covered by provisions cut from the bill continue to confront those who would ensure access to innovative, safe, efficacious, affordable therapeutics.
Sweating with Pulmonary Edema
Authors: DAN ADERKA
Journal: Annals of Internal Medicine (1984)

Letters and Corrections1 September 1984Sweating with Pulmonary EdemaDAN ADERKA, M.D., JACK PINKHAS, M.D.DAN ADERKA, M.D.Search for more papers by this author, JACK PINKHAS, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-101-3-402_1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: A recent article (1) has reviewed the latest developments in pulmonary edema. Despite the progress in understanding the pathogenesis of this emergency condition, there are still no objective clinical signs for staging the severity of the pulmonary edema or for monitoring the efficiency of treatment in the first few minutes after its initiation.We have been impressed that the distribution of perspiration may be a useful clinical sign. We followed this sign prospectively in 48 patients with pulmonary edema and found that the clinical severity was clearly related to the distribution of sweat: In 10 patients with...Reference1. CRANDALL E, STAUB N, GOLDBERG H, and EFFROS R. Recent developments in pulmonary edema. Ann Intern Med. 1983;99:808-22. LinkGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: DAN ADERKA, M.D.; JACK PINKHAS, M.D.Affiliations: Beilinson Medical Center Petah Tiqva, Israel 49 100 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 September 1984Volume 101, Issue 3Page: 402-402KeywordsEdemaPathogenesisSweat ePublished: 1 December 2008 Issue Published: 1 September 1984 PDF downloadLoading ...