THE COEXISTENCE OF TOXIC HEPATITIS, ACUTE HEMOLYTIC ANEMIA AND RENAL DAMAGE FOLLOWING SULFANILAMIDE THERAPY; REPORT OF TWO CASES
Authors: Maxwell Spring, Isidor Bernstein
Journal: Annals of Internal Medicine (1940)

Case Reports1 July 1940THE COEXISTENCE OF TOXIC HEPATITIS, ACUTE HEMOLYTIC ANEMIA AND RENAL DAMAGE FOLLOWING SULFANILAMIDE THERAPY; REPORT OF TWO CASESMAXWELL SPRING, M.D., ISIDOR BERNSTEIN, M.D.MAXWELL SPRING, M.D.Search for more papers by this author, ISIDOR BERNSTEIN, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-14-1-153 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptIn 1937 Harvey and Janeway1first described acute hemolytic anemia as a toxic manifestation of sulfanilamide therapy. They presented three cases in adults. Shortly thereafter Kohn2and Willis3each presented a case in an infant. Wood4studied 522 patients, 144 children and 378 adults, receiving sulfanilamide and found that 21 developed acute anemia. Of these, 12 or 8.3 per cent were children, and nine or 2.4 per cent were adults. Long, Bliss and Feinstone5in their study of 307 adults and 101 children found the incidence 2.9 per cent and 8.9 per cent respectively. In 1938 Bannick, Brown and Foster6...References1. HARVEYJANEWAY AMCA: The development of acute hemolytic anemia during the administration of sulfanilamide, Jr. Am. Med. Assoc., 1937, cix, 12-16. CrossrefGoogle Scholar2. KOHN SE: Acute hemolytic anemia during treatment with sulfanilamide, Jr. Am. Med. Assoc., 1937, cix, 1005-1006. CrossrefGoogle Scholar3. WILLIS T, quoted by WOOD, W. B., JR.: Anemia during sulfanilamide therapy, Jr. Am. Med. Assoc., 1938, cxi, 1916-1919. Google Scholar4. WOOD WB: Ibid. Google Scholar5. LONGBLISSFEINSTONE PHEAWH: Mode of action, clinical use and toxic manifestations of sulfanilamide, Jr. Am. Med. Assoc., 1939, cxii, 115-121. CrossrefGoogle Scholar6. BANNICKBROWNFOSTER EGAEFP: The therapeutic effectiveness and toxicity of sulfanilamide, Jr. Am. Med. Assoc., 1938, cxi, 770-777. CrossrefGoogle Scholar7. GARVIN CF: Toxic hepatitis due to sulfanilamide, Jr. Am. Med. Assoc., 1938, cxi, 2283-2285. CrossrefGoogle Scholar8. HAGEMANBLAKE POF: A specific febrile reaction to sulfanilamide, Jr. Am. Med. Assoc., 1937, cix, 642-646. CrossrefGoogle Scholar9. OTTENBERG R: Clinical experiences with sulfanilamide therapy, New York State Jr. Med., 1939, xxxix, 418-430. Google Scholar10. JENNINGSSOUTHWELL-SANDER GHG: Anemia and agranulocytosis during sulfanilamide therapy, Lancet, 1937, ccxxxiii, 898-901. CrossrefGoogle Scholar11. EGGLESTONWEISS CS: The use of sulfanilamide in the treatment of various infections, Am. Jr. Med. Sci., 1938, cxcv, 701-708. CrossrefGoogle Scholar12. LONGBLISS PHEA: Toxic manifestations of sulfanilamide, Ann. Surg., 1938, cviii, 808-811. CrossrefGoogle Scholar13. BOYD W: Pathology of internal disease, Second Ed., 1936, Lea and Febiger, Philadelphia, pp. 358-359. Google Scholar14. RICH A: Pathogenesis of forms of jaundice, Bull. Johns Hopkins Hosp., 1930, xlvii, 338-377. Google Scholar15. WEIR JF: Hepatitis, Jr. Am. Med. Assoc., 1938, cxi, 1356-1362. CrossrefGoogle Scholar16. MOLITORROBINSON HH: Some pharmacological and toxicological properties of sulfanilamide and benzyl sulfanilamide, Jr. Pharmacol. and Exper. Therap., 1939, lxv, 405-423. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Bronx, New York*Received for publication April 1, 1940.From the Medical Services of Dr. Henry Schumer and Dr. Emil Koffler, The Bronx Hospital, Bronx, New York.We are indebted to Dr. Henry Schumer and Dr. Emil Koffler for permission to report these cases. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byDrugs, Chemicals and HemolysisToxic manifestations in the newborn infant following placental transmission of sulfanilamide 1 July 1940Volume 14, Issue 1Page: 153-164KeywordsAnemiaChildrenHemolytic anemiaHepatitisInfantsMedical services ePublished: 1 December 2008 Issue Published: 1 July 1940 PDF downloadLoading ...