tbuckley/cabot-search huggingface dataset:
Indirect Method for Measurement of Pressure in Blood Capillaries
Authors: M. INTAGLIETTA, B. W. ZWEIFACH
Journal: Circulation Research (1966)

The capillary hydrostatic pressure of blood was measured indirectly. We used a microneedle to occlude exposed mesenteric capillaries in rats and frogs without trauma and then determined the motion of the trapped red blood cells that resulted from the absorption or filtration of water through the capillary wall. The trajectory of red cells was determined from enlarged timed photomicrographs that cover both sides of the occlusion. Gain or loss of water was measured by following the trajectory of two or more red cells to avoid errors due to injury and incomplete occlusion and extrapolating the motion to the instant of occlusion. Pressures were calculated from Starling's formula for fluid exchange. We assumed that the tissue parameters are an unknown constant in acute preparations; we used available values of filtration coefficients and colloidal osmotic pressures. The results show that 70 to 80% of the capillaries tested lost fluid, and therefore, their blood hydraulic pressure was higher than colloidal osmotic pressure. The pressures calculated in this way were similar to those measured by techniques requiring puncture of the capillary wall. Capillary arteriovenous pressure differences were approximately 4 mm Hg.
Changing Patterns of Hip Fracture Care Before and After Implementation of the Prospective Payment System
Authors: John F. Fitzgerald, Leonard F. Fagan, William M. Tierney, Robert S. Dittus
Journal: JAMA (1987)

We tested the hypothesis that since the implementation of the prospective payment system (PPS), elderly patients hospitalized for hip fractures receive shorter, less care-intensive hospitalizations and are more frequently institutionalized. In blinded fashion, we reviewed the charts of elderly patients with hip fractures admitted to a municipal hospital from 1981 through 1985. Demographic and clinical characteristics of patients treated before implementation of the PPS were similar to patients treated thereafter. After implementation of the PPS, the mean length of hospitalization fell from 16.6 to 10.3 days, and the mean number of physical therapy sessions received decreased from 9.7 to 4.9. Concomitantly, the proportion of patients discharged to a nursing home increased (21% to 48%), as did the proportion receiving nursing home care at six months after discharge (13% to 39%). This increase in long-term nursing home placement suggests that the quality of care for elderly patients with hip fractures may have deteriorated.
Benefits of animal research and the doctor's responsibility.
Authors: H Hewitt
Journal: BMJ (1990)

SIR,-The dangers of intravenous thrombolvsis treatment have been comprehensively reviewed by Dr M C Petch.' We report a case of haemorrhage induced by streptokinase successfully treated with intravenous tranexamic acid.Tranexamic acid inhibits plasminogen activation and thrombus fibrinolysis and is referred to in the British National Formulary for use in streptokinase overdosage.A 58 year old man with severe ischaemic heart disease presented with chest pain and electro- cardiographic changes characteristic of myocardial infarction.One hour after receiving streptokinase he developed haemoptysis, haematuria, and progressive focal neurological signs suggesting right cerebral haemorrhage.He was treated with intravenous tranexamic acid (1 g by slow intravenous infusion six hourly).The haemorrhage ceased after the first infusion, and his neurological signs resolved over two days.Aprotinin and fresh frozen plasma are useful in reversing the coagulopathy subsequent to giving streptokinase,2 and tranexamic acid should be evaluated as an immediate antidote to strepto- kinase.These agents may be of great value used in conjunction when streptokinase has been given inappropriately or dangerous bleeding has occurred.
A piece of my mind. Another Saturday
Authors: M. M. DeHart
Journal: JAMA (1990)

Dark and early one Saturday morning, I borrowed some time from prerounding to buy an offering for the floor nurses. It was my 50th consecutive day of internship on the "A team," the vascular surgery team, as well as the 50th consecutive day without sunshine hitting my face. I hoped the early start might provide a timely escape from the hospital later. I set a dozen doughnuts on the counter, and after returning my "Good morning," a nurse calmly offered, "Oh, Mr Batte is having a little chest pain." Mr Batte was a typical A team player. He had come to our clinic in the middle of February complaining of a return of his claudication. His ache was relieved only when he stopped his activity and smoked a cigarette. He was angry. His pain had increased the pack-a-day habit he had only recently mastered to the two-pack-a-day habit he had
Genomic Medicine and Lung Diseases
Authors: David M. Center, David A. Schwartz, Julian Solway, Dorothy Gail, Aaron D. Laposky, Qing S. Lin, Weiniu Gan
Journal: American Journal of Respiratory and Critical Care Medicine (2012)

The recent explosion of genomic data and technology points to opportunities to redefine lung diseases at the molecular level; to apply integrated genomic approaches to elucidate mechanisms of lung pathophysiology; and to improve early detection, diagnosis, and treatment of lung diseases. Research is needed to translate genomic discoveries into clinical applications, such as detecting preclinical disease, predicting patient outcomes, guiding treatment choices, and most of all identifying potential therapeutic targets for lung diseases. The Division of Lung Diseases in the National Heart, Lung, and Blood Institute convened a workshop, "Genomic Medicine and Lung Diseases," to discuss the potential for integrated genomics and systems approaches to advance 21st century pulmonary medicine and to evaluate the most promising opportunities for this next phase of genomics research to yield clinical benefit. Workshop sessions included (1) molecular phenotypes, molecular biomarkers, and therapeutics; (2) new technology and opportunity; (3) integrative genomics; (4) molecular anatomy of the lung; (5) novel data and information platforms; and (6) recommendations for exceptional research opportunities in lung genomics research.
Bringing New PET Drugs to Clinical Practice - A Regulatory Perspective
Authors: Joseph C. Hung
Journal: Theranostics (2013)

The regulatory framework for radioactive drugs, in particular those used in positron emission tomography (PET) scans, has been gradually established since the release of the Food and Drug Administration Modernization Act in 1997. Various guidances specially tailored to accommodate special properties of PET drugs have been issued by the Food and Drug Administration (FDA) in order to ensure this valuable technology (i.e., PET molecular imaging) will continue to be available to patients and yet the safety and efficacy of PET drugs are well regulated so that public health will be protected. This article presents several key elements of this regulatory framework for PET drugs. New regulatory avenues proposed by the FDA to facilitate the research and development process to bring more new PET drugs to clinical practice, as well as to foster the opportunity of using "orphan" PET drugs in clinical practice are also discussed in this paper.
Selling Ourselves: The Ethics of Paid Living Kidney Donation
Authors: Nancy S. Jecker
Journal: The American Journal of Bioethics (2014)

Click to increase image sizeClick to decrease image size ACKNOWLEDGMENTSThis paper was written during June 2014 while I was a participant in the National Endowment for the Humanities Institute “Meanings of Property,” hosted by Marist College. I am grateful to Institute faculty and the institute director, Dr. Ann Davis, for their thoughtful conversations that advanced my thinking about this topic.
Occult Chronic Septic Arthritis Due to Proteus mirabilis
Authors: Joe G. Hardin
Journal: JAMA (1978)

A MAN with long-standing adult Still's disease<sup>1</sup>had a<i>Proteus mirabilis</i>arthritis of the hip a year following an intra-articular injection of 30 mg of prednisolone tebutate. Despite appropriate antibiotic therapy and no symptoms suggestive of a continued pyarthrosis, he still had the same organism in the hip at successful joint replacement more than six months later. To my knowledge, it has not previously been clearly demonstrated that such infections may follow a protracted course of this relatively benign nature. <h3>Report of a Case</h3> A 36-year-old man had a recurring febrile illness since the age of 18 years, ultimately diagnosed as late-onset Still's disease. In 1971, bilateral hip arthritis was first noted, and his long-standing prednisone therapy was permanently discontinued because of increasing side effects. In March 1975, an attack of pain in the left hip and shoulder was unresponsive to 150 mg/day of indomethacin, and approximately 30 mg
OBSERVATIONS ON THE ABSORPTION, DISTRIBUTION AND EXCRETION OF SULPHAPYRIDINE, DAGENAN OR M. &amp; B. 693 1
Authors: W. Hurst Brown, William B. Thornton, J. Stuart Wilson
Journal: Journal of Clinical Investigation (1939)

This preparation is a 33 per cent solution of the sodium salt of Dagenan, contained in ampoules of 3 cc.content.Clinical trials of the drug in this form are still in progress. OBSERVATIONS Observations on oral dosageAll but 2 of the 90 cases treated at some time received sulphapyridine by mouth; some of these received supplemental intravenous, or intra- 2The authors wish to record their appreciation to Poulenc Freres for providing free supplies of Dagenan and Solu-dagenan for use in this study.B The authors are pleased to acknowledge their indebt- edness to Dr. Perrin H. Long and to Dr
Inappropriate Use of Lumbar Magnetic Resonance Imaging: Limitations and Potential Solutions—Reply
Authors: Derek J. Emery, Thomas E. Feasby
Journal: JAMA Internal Medicine (2013)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Internal Medicine HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Internal Medicine journal
Guidelines for the Clinical Diagnosis of Lyme Disease
Authors: Peter Tugwell
Journal: Annals of Internal Medicine (1998)

Letters1 September 1998Guidelines for the Clinical Diagnosis of Lyme DiseasePeter Tugwell, MD, MSc, Allen Steere, MD, and Arthur Weinstein, MDPeter Tugwell, MD, MScOttawa General Hospital; Ottawa, Ontario K1H 8L6, CanadaNew England Medical Center; Boston, MA 02111New York Medical College; Valhalla, NY 10595Search for more papers by this author, Allen Steere, MDOttawa General Hospital; Ottawa, Ontario K1H 8L6, CanadaNew England Medical Center; Boston, MA 02111New York Medical College; Valhalla, NY 10595Search for more papers by this author, and Arthur Weinstein, MDOttawa General Hospital; Ottawa, Ontario K1H 8L6, CanadaNew England Medical Center; Boston, MA 02111New York Medical College; Valhalla, NY 10595Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-129-5-199809010-00019 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail IN RESPONSE:Dr. Liegner and Ms. Kochevar and Dr. McCaulley raise the issue of the frequency and implications of false-negative results on laboratory tests in patients with true Lyme disease.Liegner and Kochevar suggest that such patients may have negative ELISA results but positive or suspicious Western blots, claiming that this differs from the experience with HIV testing. In good laboratories with careful calibration of ELISA, this has not been the case. In these laboratories, ELISA almost always yields positive or indeterminate results in cases of true Lyme disease. Liegner and Kochevar state that the presence of one or two ... Author, Article, and Disclosure InformationAffiliations: Ottawa General Hospital; Ottawa, Ontario K1H 8L6, CanadaNew England Medical Center; Boston, MA 02111New York Medical College; Valhalla, NY 10595 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 September 1998Volume 129, Issue 5Page: 423KeywordsAntibioticsChronic fatigue syndromeEnzyme linked immunosorbent assayLyme diseaseMemoryPatientsResearch laboratoriesSerologySpecificityWestern blot Issue Published: 1 September 1998 Copyright & PermissionsCopyright © 1998 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Infant Mortality Receiving Increasing Attention
Authors: Teri Randall
Journal: JAMA (1990)

IN ITS ideal sense, the epidemiology of infant mortality transcends the mere recording of infant deaths. Rather, it extends back to the infants' births to determine the medical and social context into which they were born. Only then can health care workers identify weaknesses in maternal and infant care and design strategies to address these problems. Despite the importance of linking data from death certificates (age, cause of death, state, and race) with data from birth certificates (the infant's birth weight, live-birth order, length of gestation, and type of delivery and the mother's education, age, marital status, and prenatal care history), the years between 1960 and 1980 lapsed without a national linkage study. "One of the biggest issues of the 1980s was, which babies are dying? How can we characterize the ones that aren't going to do well? We can't answer that question without linking the deaths to the births,"
Supplementary Imaging for Breast Cancer Screening in High-Risk Women
Authors: Tetsuji Fujita
Journal: JAMA (2012)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Heredity and Multiple Epiphyseal Dysplasia
Authors: Richard C. Juberg
Journal: JAMA (1977)

<h3>To the Editor.—</h3> In their family case report on multiple epiphyseal dysplasia (236:2629, 1976), Drs Mena and Pearson incorrectly interpreted the pedigree. Unfortunately, their failure to recognize a typical example of autosomal dominant inheritance appeared not just in the text but also prominently in the synopsis-abstract. The characteristics of inheritance due to a single, completely dominant, rare autosomal gene include (1) direct transmission from affected person to affected person, without skips or breaks in continuity, (2) two sexes affected in equal numbers, and (3) approximately one half of the offspring of affected persons similarly affected.<sup>1</sup>In the article, the authors stated that "the second generation... showed a dominant pattern, but the third generation did not." Yet every affected person in the third generation has an affected parent in the second generation, which is entirely consistent with this form of inheritance. The fact that only three of eleven progeny of
Self-deception is adaptive in itself
Authors: Louisa C. Egan
Journal: Behavioral and Brain Sciences (2011)

Abstract Von Hippel &amp; Trivers reason that the potential benefits of successfully deceiving others provide a basis for the evolution of self-deception. However, as self-deceptive processes themselves provide considerable adaptive value to an individual, self-deception may have evolved as an end in itself, rather than as the means to an end of improving other-deception.
Specific hyposensitization in atopic dermatitis
Authors: MARIA C. DI PRISCO FUENMAYOR, R.H. CHAMPION
Journal: British Journal of Dermatology (1979)

Specific hyposensitization is rarely advocated for the treatment of atopic dermatitis. Good results have been obtained in fifteen mainly adolescent and adult patients selected from over 3,000 patients with atopic dermatitis. Criteria included a history of exacerbations of the dermatitis after exposure to the antigen, an airborne antigen which could not be avoided, a rather distinctive clinical picture and symptoms bad enough to warrant the considerable difficulties involved.
Relationship between saliva and free and total plasma theophylline concentrations in patients with chronic airflow obstruction.
Authors: P Ebden, D Leopold, D Buss, A P Smith, P A Routledge
Journal: Thorax (1985)

Total plasma and mixed stimulated saliva theophylline concentrations (by high performance liquid chromatography) and free plasma theophylline concentrations (by equilibrium dialysis) were measured in simultaneously collected samples from 32 outpatients receiving chronic oral theophylline treatment, who had received the drug at least two hours before sampling. There was a close relationship between saliva and total plasma theophylline concentration and between total saliva and free plasma concentration. The mean saliva to total plasma drug concentration ratio was 0.69 (SE 0.09) and the mean difference between paired saliva and free plasma concentration was 0.65 (0.17) microgram/ml. It is concluded that stimulated mixed saliva provides a simple, non-invasive method of assessing total (and free) plasma theophylline concentrations during chronic oral treatment. The therapeutic range for saliva, corresponding to the generally accepted total plasma concentration range (10-20 micrograms/ml), is approximately 7-14 micrograms/ml.
STUDIES ON IMMUNOLOGICAL RELATIONSHIPS AMONG THE PNEUMOCOCCI
Authors: John Y. Sugg, James M. Neill
Journal: The Journal of Experimental Medicine (1929)

The paper reports evidence of an immunological relationship between one variety of Saccharomyces ceremsise and the Type II variety of Diplococcus pneumonix (Pneumococcus). The most convincing data consisted of the reactions of the Type II bacteria with potent antiyeast serum which agglutinated, and protected mice against these pneumococci as well as the average antiserum obtained by immunization of rabbits with Type II bacteria themselves. The reactivity of the antiyeast serum is strictly specific to the Type II variety of Pneumococcus in the sense that it is entirely devoid of antibodies reactive with Type I or III. The results of absorption experiments with both the antiyeast (rabbit) serum and the anti-Type II (horse) serum were the same as those usually obtained in analogous experiments with immunologically related, but not identical, kinds of bacteria. The immunological relationship of the yeast and the Type II pneumococcus is apparently based upon S-anti-S reactions. It represents an example of heterogenetic specificity which is of particular interest because of the wide genetic separation of the pathogenic schizomycete and the saprophytic ascomycete. Data on the individual irregularity in the yeast-agglutinating capacity of serum from non-immunized or "normal" rabbits are presented as experimental facts.
TCT-686 T-stenting with Two Drug-Eluting Stents Versus One Drug-Eluting Stent with Side Branch PTCA: Long-Term Pathological Findings in Bifurcation Lesions
Authors: Seung-Jin Oh, Armando Tellez, Maxwell Afari, Gerard Conditt, Jenn McGregor, Yanping Cheng, Geng-Hua Yi, Renu Virmani, Juan Granada, Greg Kaluza
Journal: Journal of the American College of Cardiology (2012)
Analysis of 259 Flying-bomb Casualties
Authors: R. C. Bell
Journal: BMJ (1944)

The treatment of throat carriers of haemolytic streptococci proved disappointing, as was anticipated.Nevertheless it is of interest that they became negative while undergoing treatment, and, in the case of the medical student described, this fact proved of practical value.In the small series of patients so far treated it appeared that surgical conditions of the mouth and throat could be kept free from pathogenic organisms during administration of the pastilles, with marked symptomatic relief.On bacteriological grounds faucial diphtheria should be an indication for treatment with .penicillinpastilles.Unfortunately we have as yet been unable to obtain suitable cases, but it is hoped to publish these results later in a fuller report.We would like to express our gratitude to the Penicillin Clinical Trials Committee of the Medical Research Council and Prof. L. P. Garrod for providing the penicillin which made the investigation possible, and to the latter for his encouragement and helpful criticism.We are indebted to Miss G. E. Root for grouping the streptococci and cheerfully accepting other onerous duties.We would also like to thank Dr. Paton, the matron, and staff of the