tbuckley/cabot-search huggingface dataset:
Was Rembrandt Stereoblind?
Authors: Margaret S Livingstone, Bevil R Conway
Journal: New England Journal of Medicine (2004)

dr. pietrangelo replies: MRI can undoubtedly be a useful noninvasive alternative to liver biopsy for quantifying the hepatic iron concentration.It may make it possible to avoid performing so many liver biopsies, such as those performed for workups of unexplained hyperferritinemia without clear evidence of liver disease 1 (often encountered in nonhemochromatotic hereditary iron overload 2 ), or for the follow-up of known iron-overload disorders.However, the purpose of the biopsy in the proposed algorithm in my article is not for the detection or quantification of hepatic iron overload but for the diagnosis of hereditary hemochromatosis.My definition of this disease may be at variance with that adopted by Dr. Castiella and colleagues. 3In my view, in patients with nondiagnostic genetic tests and persistent biochemical signs of iron overload, confirmation of clinically suspected hereditary hemochromatosis requires documentation not only of the presence but also of the typical cellular-distribution pattern of excess iron in hepatic tissues. 4Both can be assessed with biopsy, whereas current MRI techniques provide only the quantitative data.
Outpatient closure of the patent ductus arteriosus.
Authors: D L Wessel, J F Keane, I Parness, J E Lock
Journal: Circulation (1988)

We have modified and applied to selected outpatients the transvenous approach to correction of patent ductus arteriosus (PDA) with the Rashkind PDA Occluder. Modifications included establishing the diagnosis and PDA anatomy before catheterization with echocardiography. The sedation/anesthetic regimen was altered to meet the needs with respect to transcatheter PDA closure rather than diagnostic cardiac catheterization. Anticoagulation was avoided. A strategy for management of pin entrapment in the foam was devised. Residual trans-PDA flow after umbrella placement was temporarily occluded with balloon-tipped catheters. These modifications were used in 23 consecutive patients with uncomplicated PDA. Closure was successful in each child. Nineteen of 23 patients were discharged on the day of the procedure. No serious complications were encountered.
Phlebitis Associated With Noninvasive 24-Hour Ambulatory Blood Pressure Monitor
Authors: Patrisha C. Creevy
Journal: JAMA (1985)

To the Editor.—  The ambulatory blood pressure monitor is a recently developed device used in diagnosis and treatment of hypertension. Previous reports have suggested that there have been no adverse effects while using noninvasive 24-hour blood pressure monitors.1Recently, development of the Rumpel-Leede sign in association with use of a noninvasive ambulatory blood pressure monitor has been reported inJAMA, demonstrating that complications can occur with this device.2  We have used 24-hour ambulatory blood pressure monitoring for the past 18 months in both research investigations and in a wide range of clinical circumstances. The blood pressure cuff is applied in the usual fashion and attached to a microprocessor-controlled, battery-powered compressor and worn like a Holter monitor. Cuff inflation causes recurrent, intermittent obstruction to veins, which might lead to the development of thrombophlebitis. This letter reports a malfunction of this device associated with clinical thrombophlebitis occurring in alternate arms
Definition of Acute Respiratory Distress Syndrome—Reply
Authors: Gordon D. Rubenfeld, Arthur S. Slutsky, B. Taylor Thompson, for the ARDS Definition Task Force
Journal: JAMA (2012)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Genome-wide responses of a pathogenic bacterium to its host
Authors: David A. Relman
Journal: Journal of Clinical Investigation (2002)

abundance and processing; and (c) protein expression, modification, and localization. Of these, a wealth of information bears on gene transcriptional regulation. Data from completed bacterial genome sequences suggest a direct relationship between the breadth of environmental conditions encountered by a bacterium and the number of genes in its genome that are predicted to encode transcriptional regulatory factors (2). Escherichia coli is particularly well endowed, presumably reflecting environmental transitions in and out of the intestinal tract (3). On closer examination of this species, we now recognize an immense degree of genomic heterogeneity among different serovars and pathovars.
Cancer in the Residual Stomach After Gastric Resection for Duodenal Ulcer
Authors: Nicholas J. Capos
Journal: JAMA (1961)

CANCER of the gastric remnant, developing after gastric resection for duodenal ulcer, is uncommon. Recently Cote and associates<sup>1</sup>of Mayo Clinic reported 5 such cases over a period of 50 years, 1905 through 1954. They concluded that cancer of the stomach rarely develops in patients who have been treated for duodenal ulcer by gastric resection. Pack and Banner<sup>2</sup>of Memorial Center for Cancer, New York, report 2 cases among 1,623 case records of gastric cancer. Freedman and Berne<sup>3</sup>surveyed the world literature from 1926 to 1954 and found only 24 such cases, and reported one. We wish to report 2 such cases. This report is intended to alert the profession to the early consideration of carcinoma in the differential diagnosis of stomal lesions, at a time when surgery may be of greatest help to the patient. <h3>Report of Cases</h3><h3>Case 1.</h3> A male physician aged 78
Hyperglucagonemia in Uremia: Reversal by Renal Transplantation
Authors: GORDON L. BILBREY
Journal: Annals of Internal Medicine (1975)

Chronic renal failure in man is associated with hyperglucagonemia that is not corrected by hemodialysis. Plasma glucagon concentrations were measured in nine patients before and after renal transplantation. Mean plasma glucagon concentration in eight patients with chronic renal failure before transplantation was 295 ± 171 pg/ml (± SD). After successful transplantation, mean plasma glucagon concentration fell to 134 ± 81 pg/ml (± SD) (P < 0.001). Plasma glucagon concentration remained elevated in an additional patient who received a cadaveric graft that never functioned. Immunologic rejection of transplanted kidneys was associated with a dramatic increase of plasma glucagon concentration.
Disparities in Revascularization Rates After Acute Myocardial Infarction Between Aboriginal and Non-Aboriginal People in Australia
Authors: Deborah A. Randall, Louisa R. Jorm, Sanja Lujic, Aiden J. O’Loughlin, Sandra J. Eades, Alastair H. Leyland
Journal: Circulation (2013)

This study examined revascularization rates after acute myocardial infarction (AMI) for Aboriginal and non-Aboriginal patients sequentially controlling for admitting hospital and risk factors.
The treatment of pemphigus vulgaris. Experience with 48 patients seen over an 11-year period
Authors: O. MOURELLOU, G. C. CHAIDEMENOS, Th. KOUSSIDOU, E. KAPETIS
Journal: British Journal of Dermatology (2006)

We present a retrospective analysis of 48 patients with pemphigus vulgaris (PV) who were seen between 1978 and 1988. They were divided into three treatment groups: 25 (group A) received 40-100 mg of oral prednisone daily; eight (group B) received > 100 mg of prednisone daily; 15 (group C) received 40 mg of oral prednisone every other day and azathioprine 100 mg daily. A second immunosuppressive agent was subsequently added to the treatment regimen of three patients in group A and eight patients in group B. By 1989, 10% of the patients had been able to discontinue all therapy, and were in complete remission. Sixty-five per cent of patients were on maintenance therapy, but in clinical remission. Twenty-five per cent of the patients had died [eight in group A (31%) and four in group B (50%)] either as a consequence of the disease or its treatment. None of the patients in group C had died. Most of the deaths occurred during the first 2-3 months of therapy. Morbidity and mortality were related to the severity of the disease, to the maximum dose of prednisone required to induce remission, and to the presence of other diseases. Patients needing a total of 5 g or more of prednisone to induce a remission during the acute stage had a high mortality rate.
A Non-tumoral Esophago-bronchial Fistula Managed by lsobutyl-2-Cyanoacrylate
Authors: C. Barthelemy, J.C. Audigier, H. Fraisse
Journal: Endoscopy (1983)

Non-tumoral esophago-bronchial fistulas are usually treated by gastrostomy. This case-report describes the endoscopic obstruction with an acrylate glue in a 75-year-old woman.
Using MEDLINE to Solve Clinical Problems
Authors: Max Fink
Journal: JAMA (1993)

<h3>To the Editor.</h3> —Lindberg et al<sup>1</sup>report that physicians find that searching the MEDLINE database "is at times critical to sound patient care and favorably influences patient outcomes." This conclusion is a welcome reflection on the wisdom of the National Library of Medicine (NLM) in establishing the database and in making it available so inexpensively to the clinical and academic communities worldwide. Unfortunately, clinicians may not be aware that MEDLINE is highly selective in its decision as to which sources of information to index, and indeed its choice of journals has been described as idiosyncratic by Wakeford and Roberts.<sup>2</sup>In recent clinical reviews or case presentations we frequently read that a MEDLINE search was done, leaving the reader to believe that the relevant world literature was assessed. Henshaw<sup>3</sup>reports that MEDLINE has a select coverage, mainly of US journals, and that it has only a 36% overlap
Malignancies and false-positive serological results for hydatidosis.
Authors: S Mansueto, G Migneco, C La Cascia, M D Miceli
Journal: BMJ (1980)

SIR,-The study in your last issue by Dr I G Barrison and others (18 October, p 1040) incorporated two false premises: (a) that "heavy drinkers" are likely to reveal them- selves during "routine history taking"; and (b) that a heavy drinking habit is a necessary or sufficient condition for the diagnosis of an alcoholic.
Radionuclide Blood Pool Imaging of Calvarial Hemangioma
Authors: MORRIS L. GAVANT, JAMES D. MASSIE, BARRY GERALD
Journal: Clinical Nuclear Medicine (1983)

A patient with new onset seizures was found to have radiographic findings of a calvarial hemangioma. Because of the history, additional diagnostic tests were employed, which excluded cerebral lesions. Findings characteristic of hemangioma on blood pool imaging were felt to confirm the diagnosis.
Chronic idiopathic intestinal pseudo-obstruction: clinical and intestinal manometric findings.
Authors: V Stanghellini, M Camilleri, J R Malagelada
Journal: Gut (1987)

We report the clinical and intestinal manometric findings in a group of 42 patients with chronic idiopathic intestinal pseudo-obstruction evaluated at the Mayo Clinic. The main clinical manifestations in these patients were nausea and vomiting (83%), abdominal pain (74%), distension (57%), constipation (36%), diarrhoea (29%), and urinary symptoms (17%). These symptoms preceded surgery in all patients. Air fluid levels or distended bowel loops occurred in 57% and a dilated bladder or urinary excretory pathway in 17%. All patients showed intestinal manometric abnormalities none of which are seen in healthy individuals: aberrant configuration or propagation of interdigestive motor complexes in 25 patients; bursts (greater than 2 min duration) of non-propagated phasic pressure activity in fasting and/or fed state in 30 patients; sustained incoordinated fasting pressure activity in 15 patients; and inability of an ingested meal to convert fasting into fed pattern in 28 patients. We conclude that qualitative analysis of intestinal manometry provides evidence of gut dysmotility in patients with the clinical syndrome of chronic intestinal pseudo-obstruction. These abnormalities of motility can help to establish the correct diagnosis.
Early production of thymic stromal lymphopoietin precedes infiltration of dendritic cells expressing its receptor in allergen‐induced late phase cutaneous responses in atopic subjects
Authors: C. J. Corrigan, A. Jayaratnam, Y. Wang, Y. Liu, R. De Waal Malefyt, Q. Meng, A. B. Kay, S. Phipps, T. H. Lee, S. Ying
Journal: Allergy (2009)

Background: Thymic stromal lymphopoietin (TSLP) is an interleukin (IL)‐7‐like cytokine that triggers dendritic cell‐mediated T helper (Th)2 inflammatory responses through a receptor consisting of a heterodimer of the IL‐7 receptor alpha (IL‐7Rα) chain and the TSLP receptor (TSLPR), which resembles the cytokine receptor common gamma chain. Dendritic cells activated by TSLP prime development of CD4 + T cells into Th2 cells contributing to the pathogenesis of allergic inflammation. We hypothesized that allergen exposure induces expression of TSLP and results in recruitment of TSLPR bearing cells in the cutaneous allergen‐induced late‐phase reaction (LPR) in atopic subjects. Methods: Skin biopsies were obtained from atopic subjects ( n = 9) at various times after cutaneous allergen challenge. In situ hybridization and immunohistochemistry were used to determine TSLP mRNA expression and to measure infiltration of TSLPR + DC in skin LPR. RT‐PCR and flow cytometry were employed to analyse TSLPR expression on isolated blood DC. Results: Allergen‐induced skin TSLP expression occurred as early as 1 h after allergen challenge, whereas TSLPR + and CD11c + cells infiltrated relatively late (24–48 h). The majority of TSLPR + cells were DC co‐expressing blood DC antigen‐1 (BDCA‐1) or BDCA‐2. Freshly isolated blood DC expressed both TSLPR and IL‐7Rα chains. Maturation and stimulation with TSLP or polyriboinosinic–polyribocytidylic acid in vitro upregulated the expression of both TSLPR and IL‐7Rα chains in DC but not in chemoattractant receptor‐homologous molecule expressed on Th2 cells + CD4 + T cells. Conclusion: The data suggest that TSLP plays a role in augmenting, through DC recruitment and activation, the development of Th2‐type T cells in allergic inflammation.
Economisation of vaccination against Haemophilus influenzae type b: a randomised trial of immunogenicity of fractional-dose and two-dose regimens
Authors: Rosanna Lagos, Maria Teresa Valenzuela, Orin S Levine, Genevieve A Losonsky, Alvaro Erazo, Steven S Wasserman, Myron M Levine
Journal: The Lancet (1998)
Dating the origin and dispersal of hepatitis B virus infection in humans and primates
Authors: Dimitrios Paraskevis, Gkikas Magiorkinis, Emmanouil Magiorkinis, Simon Y.W. Ho, Robert Belshaw, Jean-Pierre Allain, Angelos Hatzakis
Journal: Hepatology (2012)

The origin of hepatitis B virus (HBV) infection in humans and other primates remains largely unresolved. Understanding the origin of HBV is crucial because it provides a framework for studying the burden, and subsequently the evolution, of HBV pathogenicity with respect to changes in human population size and life expectancy. To investigate this controversy we examined the relationship between HBV phylogeny and genetic diversity of modern humans, investigated the timescale of global HBV dispersal, and tested the hypothesis of HBV-human co-divergence. We find that the global distribution of HBV genotypes and subgenotypes are consistent with the major prehistoric modern human migrations. We calibrate the HBV molecular clock using the divergence times of different indigenous human populations based on archaeological and genetic evidence and show that HBV jumped into humans around 33,600 years ago; 95% higher posterior density (HPD): 22,000-47,100 years ago (estimated substitution rate: 2.2 × 10(-6) ; 95% HPD: 1.5-3.0 × 10(-6) substitutions/site/year). This coincides with the origin of modern non-African humans. Crucially, the most pronounced increase in the HBV pandemic correlates with the global population increase over the last 5,000 years. We also show that the non-human HBV clades in orangutans and gibbons resulted from cross-species transmission events from humans that occurred no earlier than 6,100 years ago.Our study provides, for the first time, an estimated timescale for the HBV epidemic that closely coincides with dates of human dispersals, supporting the hypothesis that HBV has been co-expanding and co-migrating with human populations for the last 40,000 years. (HEPATOLOGY 2013).
Abstract B73: Human omental-derived adipose stem cells: Modulator of ovarian cancer proliferation, migration and chemoresistance
Authors: Aleksandra Nowicka, Travis Solley, Frank C. Marini, Hadley J. Sharp, Russell R. Broaddus, Kolonin G. Mikhail, Samuel C. Mok, Wendy A. Woodward, Karen H. Lu, Ann H. Klopp
Journal: Clinical Cancer Research (2013)

Abstract Objectives: Adipose tissue contains a population of multipotent mesenchymal stromal cells (ASC) which exhibit tumor tropism, similar to bone marrow derived mesenchymal stem cells (MSC). Excess visceral adipose tissue increases the risk of ovarian cancer. The omentum is a prominent site for ovarian cancer metastasis. We hypothesize that the omentum serves as a source of ASC which promote ovarian cancer progression. Materials and Methods: ASC were isolated from the omentum (O-ASCs) of three patients with ovarian cancer. O-ASC1 was isolated from a patient with synchronous adenocarcinoma of endometrial and ovarian cancer without peritoneal metastasis; and O-ASC4 and O-ASC5 were isolated from patients with peritoneally disseminated serous ovarian cancer. Gene expression array profiling was performed with using Nimblegen arrays (Roche NimbleGen, Inc., Madison, WI). The impact of stromal cells on proliferation and chemoresistane and radio-protection of ovarian cancer cells was tested with co-culture assays using luciferase-labeled human ovarian cancer cell lines. Transwell migration assays were performed with conditioned media from O-ASC and control cell lines. To evaluate of O-ASCs tumor tropism in-vivo experiment was performed. Results: Human O-ASCs were detected engrafted within the stroma of human ovarian cancer xengrafts. O-ASC significantly promoted in-vitro proliferation and migration of ovarian cancer cell lines OVCA 429, OVCA 433, A2780. Co-culture of ovarian cancer cells with O-ASCs increased resistance to chemotherapeutic drugs and radiation. Gene expression array analysis revealed significant differences in expression profiles for group of 415 genes in sub-populations of O-ASCs. Conclusions: Adipose stem cells derived from human omentum promoted the proliferation, migration, chemoresistance and radioresistance of ovarian cancers. Clinical isolates demonstrate heterogenous effects in- vitro. Future studies will determine if tumor promoting effects of O-ASC can be predicted on the basis of clinical or disease related characteristics. Citation Format: Aleksandra Nowicka, Travis Solley, Frank C. Marini, Hadley J. Sharp, Russell R. Broaddus, Kolonin G. Mikhail, Samuel C. Mok, Wendy A. Woodward, Karen H. Lu, Ann H. Klopp. Human omental-derived adipose stem cells: Modulator of ovarian cancer proliferation, migration and chemoresistance. [abstract]. In: Proceedings of the AACR Special Conference on Advances in Ovarian Cancer Research: From Concept to Clinic; Sep 18-21, 2013; Miami, FL. Philadelphia (PA): AACR; Clin Cancer Res 2013;19(19 Suppl):Abstract nr B73.
Coronal Man: The Visible Human Male Navigator
Authors: Stanley W. Jacob
Journal: JAMA (1996)

New Media "Coronal Man" represents a multidirectional journey through the human male physical body, specifically the Visible Human Male. The first piece to be completed of The Visible Human Project developed by the Center for Human Simulation at the University of Colorado Health Sciences Center for the National Library of Medicine,<sup>1,2</sup>the Visible Human Male is an anatomy "text" of a different sort, with far-reaching potential. The first stage of the journey is twodimensional. The Coronal Man poster is a coronal image created from 1878 reformatted axial photographic "slices" of a man from head to foot. Because the images are from a real cadaver, the detailing is precise. The locations of muscles, organs, and other structures are presented from a novel perspective not captured by even the best drawing. This representation has a realism that drawings can't, or at least usually don't, match—as in the individualized feature of the degree
On the Element that Kills in Chloroform, and Other Allied Chemicals
Authors: J D Brown
Journal: BMJ (1871)

A healthy, non-consanguineous couple had a son with complete situs inversus viscerum (including dextrocardia but without other cardiac defects), broad thumbs and big toes, postaxial polydactyly, average intelligence and length proportion of the extremities, and a normal face. The common cause of these defects may have a role in the origin of sidedness and symmetry in morphogenesis.
From the Health Care Financing Administration
Authors: Gail R. Wilensky
Journal: JAMA (1991)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Direct and indirect effects of parathyroid hormone on circulating levels of fibroblast growth factor 23 in vivo
Authors: Ignacio López, M. Encarnación Rodríguez-Ortiz, Yolanda Almadén, Fátima Guerrero, A. Montes de Oca, Carmen Pineda, Vicky Shalhoub, Mariano Rodríguez, Escolástico Aguilera-Tejero
Journal: Kidney International (2011)