tbuckley/cabot-search huggingface dataset:
Epidemiologic Study of Sleep Disturbances and Psychiatric Disorders
Authors: Daniel E. Ford
Journal: JAMA (1989)

As part of the National Institute of Mental Health Epidemiologic Catchment Area study, 7954 respondents were questioned at baseline and 1 year later about sleep complaints and psychiatric symptoms using the Diagnostic Interview Schedule. Of this community sample, 10.2% and 3.2% noted insomnia and hypersomnia, respectively, at the first interview. Forty percent of those with insomnia and 46.5% of those with hypersomnia had a psychiatric disorder compared with 16.4% of those with no sleep complaints. The risk of developing new major depression was much higher in those who had insomnia at both interviews compared with those without insomnia (odds ratio, 39.8; 95% confidence interval, 19.8 to 80.0). The risk of developing new major depression was much less for those who had insomnia that had resolved by the second visit (odds ratio, 1.6; 95% confidence interval, 0.5 to 5.3). Further research is needed to determine if early recognition and treatment of sleep disturbances can prevent future psychiatric disorders. (<i>JAMA</i>. 1989;262:1479-1484)
496. Recombinant Sendai Virus Vector to Evaluate Vector Distribution in a Large Animal Model of Lung Gene Transfer
Authors: Hisao Shirohzu, Katsuhisa Mitomo, Toshiaki Tabata, Uta Griesenbach, Steve C. Hyde, Eric W. Alton, Yasuji Ueda, Mamoru Hasegawa
Journal: Molecular Therapy (2004)

Although airways are important targets for gene therapy for diseases such as cystic fibrosis or asthma, few vectors can transduce these organs. Recombinant Sendai virus (SeV) vectors can easily penetrate the mucus layer and efficiently transduce airway epithelial cells from apical side. However, the expression of transgene by the vectors of present design is transient and generally lasts only for several days. To improve lentivirus entry into airway epithelial cells, we have attempted to make the novel pseudotyped Simian Immunodeficiency Virus (SIV) vector with SeV envelope proteins, F and HN. The SIV vector could not be pseudotyped with the intact F and HN, but could be successfully pseudotyped after modification of the cytoplasmic portion of both proteins (Kobayashi et al. ASGT 2002). The new F and HN pseudotyped SIV vector was produced to the titers of more than 106 TU/ml and could be easily concentrated by centrifugation. When 108TU of SIV pseudotyped with F and HN was administered to mouse lungs through sniffing, distinct transgene (GFP) expression was detected in the alveolar epithelium (Figure 1) and bronchiolar epithelial cells (Figure 2) ten days after the transduction. In contrast, VSV-G pseudotyped SIV vectors did not transduce the lung. These results suggest that our novel pseudotyped SIV vector with F and HN may be of great value as a tool for gene therapy of respiratory diseases.
1008. Intratumoral Injection of INGN 241, a Non-Replicating Adenovector Expressing the Melanoma-Differentiation Associated Gene-7 (MDA-7/IL-24): Biologic Outcome in Advanced Cancer Patients
Authors: C. Casey Cunningham, Sunil Chada, James Merritt, Alex Tong, Neil Senzer, Yuan Zhang, Abner Mhashilkar, Karen Parker, Sasha Vukelja, Donald Richards, Jill Hood, Keith Coffee, John J. Nemunaitis
Journal: Molecular Therapy (2004)

The melanoma differentiation-associated gene-7 (mda-7) is a tumor suppressor gene whose expression causes apoptotic cell death in cells from a wide variety of solid tumor types, but has little effect in non-malignant cell cultures. To begin to characterize the safety and biologic activity of mda-7 gene transfer in a clinical setting, we conducted a phase I trial using intratumoral injections of an adenovirus containing the mda-7 construct (Ad-mda7; INGN 241) in patients with resectable solid tumor lesions. Sequential cohorts of patients received escalating doses of INGN 241 from 2 × 1010 to 2 × 1012 viral particles (vp) injected into the center of the accessible target tumor lesion. In the first 5 cohorts, the injected lesions were resected at 24 to 96 hours post injection, serially sectioned, then analyzed to determine the distribution and concentration of the viral agent, mRNA and protein expression, and assess the resultant biologic effects on the tumor cells. The last two cohorts had incisional biopsies performed pre-treatment and 30 days post treatment with the final cohort receiving 2 × 1012 vp injected twice weekly for 3 weeks of a 28 day cycle. All injected lesions demonstrated INGN 241 vector DNA and mRNA copies with the highest level near the injection site, then decreasing inversely with distance. Protein expression of MDA-7 determined by immunostaining paralleled the geographic and temporal pattern of expression of DNA and mRNA. Apoptosis staining by TUNEL reactivity also closely correlated with the expression pattern of the MDA-7 protein. Toxicity attributable to the injections consisted of transient low grade fever and mild injection site pain and erythema. Evidence of activity in two patients was seen with the repeat injections. One was a patient with metastatic melanoma who achieved a complete response in two separately injected lesions. In summary, INGN 241 delivered through intratumoral injection is well tolerated, induces apoptosis in a large percentage of tumor cells where protein expression is seen, and, with repeat injections, demonstrates evidence of clinically significant activity.
Lecture Notes on the Infectious Diseases.
Authors: Bibhat K. Mandal
Journal: Annals of Internal Medicine (1970)

Preface.List of Abbreviations.Genus Abbreviations.Section I: General Topics.- 1. Introduction.- 2. Host Response to Infection.- 3. Chemotherapy.Section II: Systems-Based Infections.- 4. Eye and Upper Respiratory Tract Infections.- 5. Lower Respiratory Tract Infections.- 6. Infections of the Cardiovascular System.- 7. Infections of the Nervous System.- 8. Rashes, Skin and Soft Tissue Infections.- 9 Infections of the Gastrointestinal Tract.- 10 Infections of the Liver and Biliary Tract.- 11 Infections of the Genitourinary Tract.- 12 Bone and Joint Infections.Section III: Multi-system Infections.- 13 Acquired Immunodeficiency Syndrome.- 14 Tuberculosis.- 15 Systemic Mycosis.Section IV: Infection in Special Groups, Zoonoses, Tropical Diseases, and Helminths.- 16 Infection in Special Groups.- 17 Tropical Infections and Non-helminthic Zoonoses.- 18 Helminthiasis.Index
Abstract 2710: Lead based development and evaluation of selective estrogen mimics in tamoxifen resistant breast cancer
Authors: Hitisha Patel, Rui Xiong, Jiong Zhao, Mary Ellen Molloy, Debra Tonetti, Gregory R.J Thatcher
Journal: Cancer Research (2014)

Abstract Tamoxifen is the standard of care for many patients with ER+ breast cancer and works by antagonizing the actions of estrogen at ER. However it poses an increased risk of endometrial cancer and thrombotic events, and most significantly, 30-50% women develop resistance to tamoxifen therapy, underlining the need for superior therapeutic options. Paradoxically, prior to tamoxifen therapy, estradiol (E2) and the ER agonist, diethylstilbestrol, had been used in breast cancer therapy, though with serious side effects. Development of Selective Estrogen Mimics (SEMs) that cause regression of tamoxifen-resistant breast cancer, but without the side effects of E2, represents a rational therapeutic strategy. Novel SEMs were developed, which in vitro in 3D cultures and in vivo caused complete regression of tamoxifen-resistant xenografts, with characteristics similar to those of E2. These SEMs did not fuel growth of estrogen-dependent T47D xenografts and did not cause uterine growth. SEM mediation of classical ER-signaling was profiled in MCF7 and MDA-MB231:β41 cells. A tamoxifen-resistant cell line, MCF-7: 5C, was used to assay induction of cell death by both E2 and the SEMs and to probe the mechanism of action. Several SEMs were observed to act as partial agonists at ERα , suggesting ideal characteristics as therapeutics. Structure-activity relationships were explored, suggesting that partial ERα agonist have the capacity to cause regression of tamoxifen-resistant tumors, without adverse effects associated with estrogenic actions in normal gynecological tissues of the breast and uterus, which might contribute to carcinogenesis. The ER-mediated agonist/antagonist activity, regression efficacy, and pharmacokinetic profiles of these SEMs were examined to obtain lead compounds that are effective with minimal estrogenic side effects. In MCF-7:5C cells, SEM-induced cell death was mediated by activation of classical nuclear ERα signaling, via induction of apoptosis. This research paves the way for use of SEMs with partial agonist activity at ER for use in tamoxifen-resistant breast cancer with enhanced safety profiles. Citation Format: Hitisha Patel, Rui Xiong, Jiong Zhao, Mary Ellen Molloy, Debra Tonetti, Gregory R.J Thatcher. Lead based development and evaluation of selective estrogen mimics in tamoxifen resistant breast cancer. [abstract]. In: Proceedings of the 105th Annual Meeting of the American Association for Cancer Research; 2014 Apr 5-9; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2014;74(19 Suppl):Abstract nr 2710. doi:10.1158/1538-7445.AM2014-2710
Response of human lung tumor xenografts to treatment with a somatostatin analogue (Somatuline).
Authors: Bogden Ae, Taylor Je, Moreau Jp, Coy Dh, LePage Dj
Journal: Cancer Research (1990)

Four human small cell lung carcinomas, NCI-H69, NCI-N417, NCI-H345, LX-1, and a non-small cell lung carcinoma, H-165, implanted s.c. as tumor xenografts in athymic nude mice, were treated with Somatuline (BIM-23014C), an endocrinologically potent octapeptide analogue of somatostatin. All tumors responded, although in varying degrees, with percentage of test/control values ranging from 3 to 88. Somatuline administered as a perilesional infusion effectively inhibited xenograft growth inducing prolonged remissions. When treatment was terminated, some tumors regrew, suggesting antimitogenic activity rather than cytocidal. Absence of observable systemic or local toxicity during prolonged treatment would support this conclusion and suggest the feasibility of long term maintenance therapy with a resultant extended survival.
A combination of molecular cytogenetic analyses reveals novel recurrent breakpoints in Mantle cell lymphoma
Authors: Itziar Salaverria, Silvia Beà, Laura Plà, Blanca Espinet, Jordi Camps, Anna Carrió, Dolors Colomer, Dolors Costa, Rosa Miró, Francesc Solé, Elias Campo
Journal: Cancer Research (2006)

Proc Amer Assoc Cancer Res, Volume 47, 2006

4206 

Mantle cell lymphoma (MCL) is an aggressive lymphoid neoplasm genetically characterized by chromosomal translocations involving the 11q13 region and its molecular counterpart BCL-1 rearrangement, leading to the overepression of CCND1 gene. experimental studies have shown that CCND1 can function as an oncogene but its tumorigenic and transforming properties seem to be less effective than other oncogenes, suggesting that other mechanisms may participate in the development and progression of MCLs. These other mechanisms presumably are secondary genomic alterations, usually affecting large chromosomal regions that may contain many candidate genes. In this study, we have analysed 29 MCL obtained at diagnosis, 19 men, 10 women, mean age 75 years (range 50-90 years), four relapsed samples obtained between 1 and 4 years after diagnosis, and five MCL cell lines (JVM-2, GRANTA-519, REC-1, JEKO-1 and NCEB-1) using G-Banding technique, multicolour-FISH (M-FISH) in 17 samples, and comparative genomic hybridization (CGH). Clinical data of all cases was available. Combined cytogenetic analysis detected the MCL-hallmark t(11;14) in all cases and was found as a single abnormality in 4 of these cases. M-FISH revealed new alterations not detected by G- Banding in 59% of the analyzed cases. Thirty-six numerical (range 1-19, mean 2.7 imbalances/case), and 51 structural aberrations (range 1-7, mean 3 imbalances/case) were observed. Furthermore, no other recurrent translocations were detected in this series. All five cell lines carried structural, including t(11;14) and numerical (except JVM-2) alterations and display different patterns of instability. Three cases and JEKO-1 cell line displayed complex translocations involving the IGH and CCND1 loci rearrangement and other chromosomes including chromosomes 8 (two cases), 10 and 17. Cytogenetic formulas were corrected using breakpoints detected by CGH. Recurrent breakpoints were identified at 1p32, 1p36, 3q25, 10p14, 11q13, 11q21, 11q23, 13q11, 13q21, 14q32, and 15q22 (two cases each, except 11q13 and 14q32). Breakpoints located at 1p32, 1p36 and 15q22 were also detected in JEKO-1, REC-1 and JVM-2 respectively. Breakpoints 1p36, 3q25, 10p14, 13q11, 13q21 and 15q22 are described for the first time in MCL. Besides 11 and 14, the most involved chromosomes in rearrangements were 1, 8, and 10 (6, 5, and 5 rearrangements, respectively). Comparison between the four sequential samples detected the same chromosomal alterations in three of them and gains of 3q24-qter and 7p in the second sample of the fourth case. In conclusion, the combination of M-FISH and CGH analysis gives a more specific approach to the genetic imbalances in MCL pathogenesis delineating several frequent regions of gain and loss and new recurrent breakpoints.
In vivo assessment of chronological ageing and photoageing in forearm skin using reflectance confocal microscopy
Authors: E.M.T. Wurm, C. Longo, C. Curchin, H.P. Soyer, T.W. Prow, G. Pellacani
Journal: British Journal of Dermatology (2012)

Skin ageing is a complex process due to intrinsic chronological factors (chronoageing) and extrinsic environmental factors. The primary extrinsic factor is cumulative ultraviolet (UV) exposure, and is therefore termed photoageing. The current standards for measuring cumulative sun damage are biopsy histology and skin microtopography. However, skin biopsies are too invasive for population studies and skin replicas render only superficial skin architecture data. Reflectance confocal microscopy (RCM) is a noninvasive imaging tool that allows for in vivo imaging of the skin at quasihistological resolution.To define and identify RCM features associated with chronological ageing and photoageing on the forearm in two age groups with different skin phototypes and to assess whether these results agree with previous findings.We obtained RCM images of dorsal and volar nonlesional skin of the lower forearm of 75 individuals with skin Fitzpatrick phototypes I-III in two age groups (20-30 years and 50-60 years). From each participant and body site, 21 RCM features were assessed and statistically significant differences between the two age groups and different forearm sites determined.RCM enabled identification of changes in architecture, cell morphology and extracellular matrix (collagen) at the level of the epidermis, dermoepidermal junction and papillary dermis. Changes that were correlated with chronological ageing and which were aggravated on the UV-exposed dorsal forearm were: loss of small skin furrows resulting in wider and less intersecting furrows; irregularity of the epidermal honeycomb pattern; irregularly distributed (mottled) pigmented keratinocytes/melanocytes; irregularity of the papillary rings and/or effacement of the rete ridges; and loss of thin collagen fibres and presence of collagen clods.We have tested previously reported and new parameters for skin ageing evaluation by RCM, and identified 15 statistically significant RCM features that can be used to quantify ageing and photoageing in forearm skin noninvasively.
Relationship of Fitness and Body Mass Index to Cardiac Disease—Reply
Authors: Timothy R. Wessel, Carl J. Pepine, Leslee J. Shaw, C. Noel Bairey Merz
Journal: JAMA (2005)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Regular Physical Activity and Risk Factors for Coronary Heart Disease
Authors: Werner Benzer, Robert Bitschnau, Ernst Groechenig, Stefan Aczel, Heinz Drexel
Journal: Circulation (1998)

Veinot et al 1 reviewed 500 heart specimens from autopsies during a 22-year period.They described the anatomy of the left atrial appendage (LAA) by determining orifice diameter, width, length, and number of lobes.They found orifice size, width, and length to be age and sex related.In men and women aged Ͼ20 years, mean orifice diameters of 1.16 and 1.07 cm, length of 2.59 and 2.53 cm, and width of 1.83 and 1.66 cm were found, respectively, as well as 1 to 4 lobes.In a study on 220 LAA casts obtained shortly after death, 2 we determined LAA morphology by describing the course and ramifications of the principal axis and by measuring minimal and maximal orifice diameters, length (bottom to top), width (at right angles), and volume.The course of the principal axis was straight (7%), slightly bent and slightly spiral (23%), slightly bent and extremely spiral (5%), extremely bent and slightly spiral (24%), or extremely bent and extremely spiral (42%).Fifty-six percent of the casts had Ͼ5 branches (orifice area Ͼ10 mm 2 ), and 47% had Ͼ40 twigs (orifice area 1 to 10 mm 2 ).The mean minimal and maximal orifice diameters were 15 and 21 mm, respectively.Mean length was 30 mm, width was 31 mm, and volume was 5220 mm 3 .The casts of 35 cases with normal cardiac findings were not different from those that showed pathological cardiac findings at autopsy.Differences between the results of the study by Veinot et al and our results can be explained as follows:1.The specimens used in the 2 studies were of different age and type of conservation.It is possible that the years of conservation led to a shrinkage and change of the elastic properties of the LAA tissue, whereas casting possibly led to dilation of the LAA.This assumption is supported by the shorter LAA length in the study by Veinot et al compared with our study.Furthermore, the number of LAA outpouchings is lower in their study compared with our study.2. Veinot et al measured the LAA tissue, whereas we measured synthetic resin casts.3. The orifice diameters were measured differently.4. Veinot et al measured width as the widest external width, whereas we measured at right angles, perpendicular to the bottom-to-top axis. 5.The definition of lobes in the study by Veinot et al differed from our definition of branches and twigs.We conclude that postmortem casts may reflect the intravitam morphology of the LAA more closely than specimens conserved for years.We demonstrate that the anatomy and morphology of the LAA is more complex, bizarre, and variable than previously thought.This should be considered when images of the LAA are being interpreted, in particular when thrombi are being diagnosed.
Heavy Night Call vs Alcohol Ingestion in Residents—Reply
Authors: J. Todd Arnedt, Judith A. Owens, Mary A. Carskadon
Journal: JAMA (2006)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2022 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Biomaterials: Magnetic Levitational Assembly for Living Material Fabrication (Adv. Healthcare Mater. 10/2015)
Authors: Savas Tasoglu, Chu Hsiang Yu, Volha Liaudanskaya, Sinan Guven, Claudio Migliaresi, Utkan Demirci
Journal: Advanced Healthcare Materials (2015)

Functional living materials with microscale compositional topographies are prevalent in nature. However, the creation of biomaterials composed of living micro building blocks, each programmed by composition, functionality, and shape, is still a challenge. On page 1469, S. Tasoglu, U. Demirci, and co-workers present a powerful yet simple approach to create living materials using a levitation-based magnetic method.
Impact of ATG-containing reduced-intensity conditioning after single- or double-unit allogeneic cord blood transplantation
Authors: Laurent Pascal, Luciana Tucunduva, Annalisa Ruggeri, Didier Blaise, Patrice Ceballos, Patrice Chevallier, Jan Cornelissen, Natacha Maillard, Reza Tabrizi, Eefke Petersen, Werner Linkesch, Henrik Sengeloev, Chantal Kenzey, Antonio Pagliuca, Ernst Holler, Hermann Einsele, Eliane Gluckman, Vanderson Rocha, Ibrahim Yakoub-Agha
Journal: Blood (2015)
Apoptotic Role of Fas/Fas Ligand System in the Regulation of Erythropoiesis
Authors: R. De Maria, U. Testa, L. Luchetti, A. Zeuner, G. Stassi, E. Pelosi, R. Riccioni, N. Felli, P. Samoggia, C. Peschle
Journal: Blood (1999)
A global perspective on caring for healthy stratum corneum by mitigating the effects of daily cleansing: report from an expert dermatology symposium
Authors: K.P. Ananthapadmanabhan, K. Subramanyan, G. Nole
Journal: British Journal of Dermatology (2012)

A symposium was held in October 2011 on skin cleansing and its role in basic skin care. The meeting was attended by an international group of leading dermatologists.