tbuckley/cabot-search huggingface dataset:
Abstract 2273: Comparison of Drug-Eluting Stents and Coronary Artery Bypass Surgery for the Treatment of Multivessel Coronary Disease
Authors: Yan Li, Bo Xu, Zhe Zheng, Wei Li, Shiju Zhang, Runlin Gao, Shengshou Hu
Journal: Circulation (2008)

Background: Numerous studies have compared the outcomes of coronary artery bypass grafting (CABG) surgery and coronary stenting for the treatment of multivessel coronary disease. In 2003 drug-eluting stents was introduced with the hope of reducing restenosis. However, limited information exists on the comparison of drug-eluting stents and CABG surgery, and it is also unclear how the long-term outcomes of drug-eluting stents compares with that of CABG surgery. Methods: We identified 3720 consecutive patients with multivessel disease who underwent isolated CABG surgery or received drug-eluting stents between April 1, 2004, and December 31, 2005, and we compared safety (total mortality, myocardial infarction) and efficacy (target-vessel revascularization) during a 2-year follow-up. These outcomes were compared after adjustment for differences in baseline risk factors among the patients. We also compared the average total costs per patient at the end of the initial hospitalization and of 1 year follow-up. Results: Patients who underwent CABG (n=1886) were older and had more comorbidities than patients who received drug-eluting stents (n=1834). Patients undergoing CABG had significantly lower 2-year rates of target-vessel revascularization (1.39% versus 13.1%). The treatment with a drug-eluting stents was associated with higher rates of total mortality [adjusted hazard ratio (HR) 1.623, 95%CI 1.069 to 2.466], and myocardial infarction. (adjusted HR 1.647, 95%CI 1.147 to 2.442). For the initial hospitalization, the average total costs per patient were similar ($8035 for CABG; $8007 for drug-eluting stents). However, total follow-up costs at 1 year remained lower for CABG ($672 vs $1086) compared with treatment with drug-eluting stents. Conclusions: For patients with multivessel disease, CABG continues to be associated with lower rates of total mortality, myocardial infarction and target-vessel revascularization than does drug-eluting stents. CABG is also likely a cost-saving strategy for patients with multivessel disease.
Overview: efficacy and safety of the rapid neuroleptization method with injectable haloperidol
Authors: P T Donlon, J Hopkin, J P Tupin
Journal: American Journal of Psychiatry (1979)

The authors review the literature on the rapid neuroleptization (titration) method with I.M. haloperidol. Most of the approximately 650 predominantly schizophrenic and manic patients represented in the studies calmed down rapidly on medication, and some demonstrated an early reduction in core psychotic symptoms. The initial doses varied widely, ranging from 1 to 30 mg, with a maximum total daily dosage of 100 mg. The medication seemed to have been well tolerated in all cases, with no reported major complications. The authors conclude that the method shows definite merit with agitated and belligerent patients. However, they make a number of specific recommendations for further research to clearly establish the effectiveness and safety of this method of neuroleptic administration.
CD Rom: Communications Skills Version 1:2
Authors: M. Houston
Journal: BMJ (1998)

Department of Behavioural Sciences, University of Nottingham £10 to medical schools ISBN 0 85358 068 5 Rating: ![Graphic][1]</img>![Graphic][2]</img> Byrne and Long were the first with Doctors talking to Patients , a seminal book published back in 1976. Up to then it just happened. Talking to patients, I mean. The problem is, a lot of it was talking at patients. Pendleton and colleagues followed with The Consultation—An Approach to Learning and Teaching , truly a great book. My own favourite has always been Stott and Davis's Model of the Consultation . I recall hanging a … [1]: /embed/inline-graphic-1.gif [2]: /embed/inline-graphic-2.gif
Quantitative Studies of the Local Cellular Response to Isoantigens&lt;xref ref-type="fn" rid="fn1"&gt;2&lt;/xref&gt;
Authors: M. E. Dreisbach, G. D. Snell, R. S. Speirs
Journal: JNCI Journal of the National Cancer Institute (1956)

Quantitative Studies of the Local Cellular Response to Isoantigens Get access M. E. Dreisbach, M. E. Dreisbach Roscoe B. Jackson Memorial Laboratory, Bar Harbor, Maine Search for other works by this author on: Oxford Academic PubMed Google Scholar G. D. Snell, G. D. Snell Roscoe B. Jackson Memorial Laboratory, Bar Harbor, Maine Search for other works by this author on: Oxford Academic PubMed Google Scholar R. S. Speirs R. S. Speirs Roscoe B. Jackson Memorial Laboratory, Bar Harbor, Maine Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 17, Issue 3, September 1956, Pages 297–303, https://doi.org/10.1093/jnci/17.3.297 Published: 01 September 1956 Article history Received: 24 April 1956 Published: 01 September 1956
Seasonal Distribution of Acute Myocardial Infarction in the Second National Registry of Myocardial Infarction 11The National Registry of Myocardial Infarction is supported by Genentech, Inc., South San Francisco, California. Genentech, Inc. reimburses ClinTrials Research, Inc. for the cost of data analysis and biostatistical services.
Authors: Frederick A. Spencer, Robert J. Goldberg, Richard C. Becker, Joel M. Gore
Journal: Journal of the American College of Cardiology (1998)
Low–Glycemic Load Diet and Resting Energy Expenditure
Authors: Katherine Esposito, Dario Giugliano
Journal: JAMA (2005)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Kawasaki disease and parvovirus B19 infection in an adult HIV-1-infected patient
Authors: M. Muniain-Ezcurra, C. Bueno-Mariscal, J. Rodríguez-Baño, A. Domínguez-Castellano, B. Balonga-Tomás, M.J. Ríos-Villegas, M.V. Borobio-Enciso, R. Pérez-Cano
Journal: Clinical Microbiology and Infection (1998)
Mortality and Ratio of Blood Products Used in Patients With Severe Trauma—Reply
Authors: John B. Holcomb, Erin E. Fox, Charles E. Wade
Journal: JAMA (2015)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Abstract P2-06-14: Clinical relevance and biological properties of oligometastatic breast cancer in lung; prognostic impact of CD44+/CD24−/low cells
Authors: Rei Mimoto, Tadashi Kobayashi, Yoshimi Imawari, Makiko Kamio, Kumiko Kato, Hiroko Nogi, Yasuo Toriumi, Ken Uchida, Hiroshi Takeyama
Journal: Cancer Research (2015)

Abstract Background: Metastatic breast cancer is a systemic disease. Our aim was to evaluate the clinical outcomes of pulmonary metastasectomy of recurrent breast tumors and to identify possible prognostic factors. Methods: We reviewed data from a registry of patients with lung metastases from breast tumors who received pulmonary metastasectomy in Jikei University Hospital between 2004 and 2011. We analyzed prognostic factors for overall survival (OS) and progression free survival (PFS) after metastasectomy. We also investigated lung metastases for the prevalence of CD44+/CD24−/low tumor cells and evaluated their prognostic significance. Results: Among 17 patients with lung metastasis of breast tumors, 5-year OS and PFS were 72% and 36%, respectively. Better OS was observed among patients with oligometastatic breast cancer (OMBC). Patients with OMBC, estrogen receptor (ER) positive cells, and disease free intervals (DFI) of &amp;gt;8 years had better PFS. The average prevalence of CD44+/CD24−/low tumor cells in lung metastases of breast cancer was 21%, ranging from 0 to 90%. The presence of CD44+/CD24−/low tumor cells influenced the progression after lung metastasectomy, with median PFS times of only 6 months in patients with high-prevalence of cancer-initiating cells. CD44+/CD24−/low cells with cancer-initiating properties were present in only 9% ± 12 of patients with OMBC but were found in 73% ± 21 of patients with non-OMBC. Conclusion: Pulmonary metastasectomy may be a treatment option for OMBC patients with lung metastases. Better prognosis of OMBC may be related to low levels of cancer-initiating cells. Citation Format: Rei Mimoto, Tadashi Kobayashi, Yoshimi Imawari, Makiko Kamio, Kumiko Kato, Hiroko Nogi, Yasuo Toriumi, Ken Uchida, Hiroshi Takeyama. Clinical relevance and biological properties of oligometastatic breast cancer in lung; prognostic impact of CD44+/CD24−/low cells [abstract]. In: Proceedings of the Thirty-Seventh Annual CTRC-AACR San Antonio Breast Cancer Symposium: 2014 Dec 9-13; San Antonio, TX. Philadelphia (PA): AACR; Cancer Res 2015;75(9 Suppl):Abstract nr P2-06-14.
Abstract P224: Sex Differences in the Risk of Stroke and HbA1c among Diabetic Patients
Authors: Gang Hu, Peter Katzmarzyk, Ronald Horswell, Yujie Wang, Jolene Johnson, Wenhui Zhao
Journal: Circulation (2014)

Background: Epidemiological studies have reported that type 2 diabetes is an independent risk factor for stroke, but how much its effect varies by sex is uncertain. Aim: To better understand the relationship between glycemic control and stroke risk in men and women, we studied a large sample of patients with type 2 diabetes with long-term follow up. Methods: We prospectively investigated the sex-specific association of different levels of HbA1c with incident stroke risk among 10,876 male and 19,278 female diabetic patients within the Louisiana State University (LSU) Hospital System. Results: During a mean follow up of 6.7 years, 2,949 incident cases of stroke were identified. The multivariable-adjusted hazard ratios (HRs) of stroke associated with different levels of HbA1c at baseline (&lt;6.0%, 6.0-6.9% [reference group], 7.0-7.9%, 8.0-8.9%, 9.0-9.9%, and ≥10.0%,) were 0.96 (95% confidence interval [CI] 0.80-1.14), 1.00, 1.04 (0.85-1.28), 1.11 (0.89-1.39), 1.10 (0.86-1.41), and 1.22 (0.92-1.35) (P trend =0.66) for males, and 1.03 (0.90-1.18), 1.00, 1.09 (0.94-1.26), 1.19 (1.00-1.42), 1.32 (1.09-1.59), and 1.42 (1.23-1.65) (P trend &lt;0.001) for females, respectively. The graded association of HbA1c during follow-up with stroke risk was observed among female diabetic patients (P trend=0.066). When stratified by race, with glucose-lowering agents or not, this graded association of HbA1c with stroke was still present. When stratified by age, the adjusted HRs were significantly higher in women older than 55 years compared to younger women. Conclusions: The current study suggests a graded association between HbA1c and the risk of stroke among female patients with type 2 diabetes and poor control of blood sugar has a stronger effect in women older than 55 years.
Improving child health: the role of research
Authors: F Dabis, J Orne-Gliemann, F Perez, V Leroy, M L Newell, A Coutsoudis, H Coovadia
Journal: BMJ (2002)

Working Group on Women and Child Health Child health has improved greatly in the past decade, thanks to research that has quantified health problems and identified strategies for improving child health.The Working Group on Women and Child Health reviews the major advances in this field in developing countries since 1990 and argues that research is fundamental to further improvements in child health Child mortality (before age 5 years) has shown a relative decrease of 15% since 1990 but remains above 100 per 1000 live births in more than 40 countries. 1 The risk of death can be reduced through evidence based interventions such as immunisation and oral rehydration treatment.Research has helped to quantify child health problems, identified strategies to improve health, and shown the effectiveness of interventions.In preparation for the forthcoming United Nations special session on children, we review the major advances in child health in developing countries since 1990 and illustrate the role of research in this progress. MethodsWe reviewed the literature published between January 1990 and June 2001 to document progress of and challenges in child health research since the previous UN session for children in 1990.The Medline search strategy was based on the combination (Boolean operator AND) of "child" and "developing countries" and the following keywords: breastfeeding, diarrhoeal diseases, health system, HIV infection, immunisation, injuries, malaria, measles, mental health, mortality, opportunistic diseases, oral health, perinatal health, respiratory infections, sanitation, and welfare.The search identified 4701 references, of which we selected 488 on title and 137 on content.We identified unpublished documents and reports by major child health institutions through an electronic mail survey to over 90 informants in national and international public, private, and non-profit organisations. Research to improve child survivalChild health research aims to quantify childhood mortality and morbidity, improve understanding of causes, and identify appropriate interventions (table 2).The
Evidence based management of hypertension: Cardiovascular risk factors and their effects on the decision to treat hypertension: evidence based review
Authors: R. Padwal
Journal: BMJ (2001)

This is the second in a series of five articles 

Blood pressure, like any physiological variable, is normally distributed in the population. Not surprisingly, expert bodies disagree substantially on the definition of hypertension—of the 27 national hypertension societies represented at the 17th world conference of the Hypertension League Council held in Montreal in 1997, 14 use 140/90 mm Hg to diagnose hypertension and 13 use 160/95 mm Hg.1

#### Summary points

There is a continuous, strong, and graded relation between blood pressure and cardiovascular disease, but no clear threshold value separates hypertensive patients who will experience future cardiovascular events from those who will not

Risk of cardiovascular disease depends on blood pressure, coexistent risk factors, and whether there is hypertensive damage to target organs

Numerous factors definitely increase cardiovascular risk, including age, male sex, family history, raised cholesterol, smoking, diabetes mellitus, obesity, sedentary lifestyle, and left ventricular hypertrophy

Models can be used to predict an individual's risk of cardiovascular disease to define the expected benefits and harms of treatment

### Relative risk

Most population based studies confirm that hypertension increases an individual's risk of various cardiovascular consequences approximately two to three times (figure). Large population based cohort studies consistently show continuous, strong, and graded relations between blood pressure (particularly systolic pressure) and the subsequent occurrence of various atherosclerotic events. 2 3 The sizes of the relative risks reported in each study depend on the duration of follow up and the definition of hypertension in use.4 These relative risks are consistent across all settings5 and for all patient subgroups, including those with and without known atherosclerotic disease.6



Risk of atherosclerotic disease in people with hypertension



Multiple high quality long term cohort studies and randomised clinical trials have shown that the risks from raised blood pressure can be partially reversed. 6 7 Two important …
Role of MT1-MMP and Kras in invasive pancreatic tumors with pronounced fibrosis.
Authors: S. B. Krantz, S. Dangi-Garimella, M. A. Shields, P. J. Grippo, D. J. Bentrem, H. G. Munshi
Journal: Journal of Clinical Oncology (2010)

4158 Background: Pancreatic ductal adenocarcinoma (PDAC), which is currently the fourth leading cause of cancer-related death in the United States, is associated with extensive fibrosis known as the desmoplatic reaction, which surrounds the infiltrating tumor. Recently, it was shown that this fibrotic reaction limits the delivery and efficacy of chemotherapy, thereby limiting the progress made in the treatment of this cancer. To identify potential therapeutic targets to overcome the desmoplastic reaction, we examined the interplay between fibrosis and a key proteinase required for growth and invasion in the collagen-rich microenvironment. Previously we had published that the proteinase membrane type 1-matrix metalloproteinase (MT1-MMP, MMP-14) is overexpressed in pancreatic cancer and can be induced by the collagen-rich fibrosis. Methods: To further examine the contribution of MT1-MMP to pancreatic cancer progression in the in vivo microenvironment, we generated transgenic mice overexpressing MT1-MMP and mutant Kras in the pancreas. The mice were sacrificed, and their pancreata were permanently fixed and then analyzed for the presence of precancerous lesions. Results: Relative to control Kras+-only mice, Kras+/MT1-MMP+ mice demonstrated a more pronounced phenotype. The Kras+/MT1-MMP+ mice exhibited significant increases in the frequency and size of precancerous lesions, with more fibrosis both around each lesion and throughout the gland when compared to control mice. The bigenic mice also demonstrated significantly more acinar to ductal metaplasia and showed evidence of invasion into the stroma. Conclusions: Given that MT1-MMP functions to promote the desmoplastic reaction and is overexpressed in human PDAC tumors, targeting MT1-MMPprovides a new treatment strategy to address the significant challenge of delivering therapeutic agents through the desmoplastic reaction in pancreatic cancer. No significant financial relationships to disclose.
Dilated-Hypokinetic Evolution of Hypertrophic Cardiomyopathy
Authors: Elena Biagini, Fabio Coccolo, Marinella Ferlito, Enrica Perugini, Guido Rocchi, Letizia Bacchi-Reggiani, Carla Lofiego, Giuseppe Boriani, Daniela Prandstraller, Fernando M. Picchio, Angelo Branzi, Claudio Rapezzi
Journal: Journal of the American College of Cardiology (2005)
Smoking cessation in heart failure: it is never too late∗∗Editorials published in the Journal of the American College of Cardiologyreflect the views of the authors and do not necessarily represent the views of JACCor the American College of Cardiology.
Authors: James Lightwood, Kirsten E Fleischmann, Stanton A Glantz
Journal: Journal of the American College of Cardiology (2001)
Radiation-induced melanoma-associated leucoderma, systemic antimelanoma immunity and disease-free survival in a patient with advanced-stage melanoma: a case report and immunological analysis
Authors: H.E. Teulings, E.P.M. Tjin, K.J. Willemsen, G. Krebbers, C.J. van Noesel, E.H. Kemp, L. Nieuweboer-Krobotova, J.P.W. van der Veen, R.M. Luiten
Journal: British Journal of Dermatology (2013)

Melanoma is an immunogenic tumour. The development of skin depigmentation or melanoma-associated leucoderma (MAL) has been associated with favourable clinical outcome in patients with metastatic melanoma, especially after immunotherapy. Evidence for clinically meaningful enhancement of melanoma-directed autoimmunity, as indicated by MAL, after radiotherapy without immunotherapy has not yet been published.We investigated whether a patient with stage IV melanoma, who developed leucoderma in the irradiated skin areas following radiotherapy and experienced exceptional disease-free survival of 3 years despite brain metastasis, possessed antimelanoma immunity that could be linked to the favourable disease course.A detailed immunological analysis was performed consisting of immunohistochemistry of several melanoma tissues, and analyses of T cells isolated from the blood and MAL skin tissue for melanocyte/melanoma specificity and functionality, as well as the presence of a melanoma-specific antibody response.Immunological analyses showed the presence of CD8+ T cells and antibody responses directed against melanocyte differentiation antigens expressed in the primary tumour, lymph node and brain metastasis, indicating adequate tumour recognition by activated T cells.The immune responses found in this patient, probably enhanced by radiotherapy, are thought to have contributed to his favourable clinical course. Radiotherapy may act as local immunotherapy in patients with melanoma by destroying melanocytes, leading to the induction, or enhancement, of already existent antimelanoma immunity. As in patients treated with immunotherapy, this may lead to MAL, also at distant sites from the treated area. This patient is a clear example of the positive prognostic value of MAL, which is possibly induced by radiotherapy, for patients with melanoma.
Abstract 4094: High Triglycerides, Low HDL Cholesterol, and Small LDL Particles are the Main Lipid Risk Factors In Coronary Patients With Type 2 Diabetes
Authors: Heinz Drexel, Stefan Aczel, Thomas Marte, Philipp Rein, Lorena Koch, Fabian Schmid, Peter Langer, Guenter Hoefle, Christoph H Saely
Journal: Circulation (2006)

Background: Data on the impact of serum lipids on the incidence of vascular events in coronary patients with type 2 diabetes mellitus (T2DM) are scarce. The aim of this study was to identify the li...