Metronidazole-Associated Pancreatitis
Authors: Kurt A. Sanford
Journal: Annals of Internal Medicine (1988)

Brief Reports1 November 1988Metronidazole-Associated PancreatitisKurt A. Sanford, MD, James E. Mayle, MD, Howard A. Dean, DO, David S. Greenbaum, MDKurt A. Sanford, MDSearch for more papers by this author, James E. Mayle, MDSearch for more papers by this author, Howard A. Dean, DOSearch for more papers by this author, David S. Greenbaum, MDSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-109-9-756 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptMetronidazole is a widely used antiprotozoal drug prescribed for infections with Trichomonas vaginalis, Giardia lamblia, Entamoeba histolytica, and Gardnerella vaginalis as well as for generalized anaerobic infections. We report a case of recurrent pancreatitis associated with metronidazole-treated Gardnerella vaginalis infections.A previously healthy, obese, 23-year-old black woman was hospitalized after 4 days of epigastric, right upper quandrant, and back pain, associated with anorexia, nausea, and low-grade fever. The patient had previously been treated twice for gonorrhea salpingitis and three times for pneumonia. She denied a personal or family history of pancreatitis, gallbladder disease, liver disease, or hyperlipidemias. She reported only...References1. PheiferForsythDurfeePollockHolmes TPMHK. Nonspecific vaginitis: role of Haemophilus vaginalis and treatment with metronidazole. N Engl J Med. 1978;298:1429-34. CrossrefMedlineGoogle Scholar2. WallaceCushingBawdonSugawaLucasLedgerwood JRRCCA. Assessment of antimicrobial penetrance into the pancreatic juice in humans. Surg Gynecol Obstet. 1986;162:313-6. MedlineGoogle Scholar3. Finegold S. Metronidazole. Ann Intern Med. 1980;93:585-7. LinkGoogle Scholar4. GeokasBaltaxeBanksSilvaFrey MHPJC. Acute pancreatitis. Ann Intern Med. 1985;103:86-100. LinkGoogle Scholar5. MalloryKern AF. Drug-induced pancreatitis: a critical review. Gastroenterology. 1980;78:813-20. CrossrefMedlineGoogle Scholar6. NakashimaHoward YJ. Drug-induced acute pancreatitis. Surg Gynec Obstet. 1977;145:105-9. MedlineGoogle Scholar7. BanksMarks SI. Case reports. Hyperlipaemic pancreatitis and the pill. Postgrad Med J. 1970;46:576-8. CrossrefMedlineGoogle Scholar8. DavidoffTishlerRosoff FSC. Marked hyperlipidemia and pancreatitis associated with oral contraceptive therapy. N Engl J Med. 1973;289:552-5. CrossrefMedlineGoogle Scholar9. PlotnickCohenTsangCullinane BITT. Metronidazole-induced pancreatitis. Ann Intern Med. 1985;103:891-2. LinkGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: Kurt A. Sanford, MD; James E. Mayle, MD; Howard A. Dean, DO; David S. Greenbaum, MDFrom the College of Human Medicine, Michigan State University, East Lansing, Michigan. For current author addresses, see end of text. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byDrugs associated with drug-induced pancreatitis: focus on rarely discussed drugsDrug induced pancreatitis: A systematic review of case reports to determine potential drug associationsDrug-Induced Acute Pancreatitis in AdultsMetronidazole-Induced Pancreatitis: Is There Underrecognition? A Case Report and Systematic Review of the LiteratureThermal reversible rheology behaviors of biscarbamates-containing uncured epoxy composite pastesMetronidazoleNitroimidazole Antibacterial AgentsPsychogenic Vomiting Considered as Co-Morbidity With Tuberculosis in AdolescentsMetronidazole-Induced PancreatitisPancreatitis in Inflammatory Bowel DiseasesDrug-Induced PancreatitisDrug-Induced Acute Pancreatitis: An Evidence-Based ReviewLow Molecular Weight Organogels Based on Long-Chain CarbamatesMetronidazole and risk of acute pancreatitis: a population-based case-control studyAntibiotic prophylaxis in the initial management of severe acute pancreatitisMetronidazole-Induced Pancreatitis in a Patient with Recurrent Vaginal TrichomoniasisAcute and chronic pancreatitisMetronidazole-Associated PancreatitisDrug-Associated Acute Pancreatitis: Twenty-One Years of Spontaneous Reporting in The NetherlandsMetronidazole and Darkened Urine: Is There a Causal Relationship?Review article: Drug-induced pancreatitisNon-infective Acute PancreatitisDrug-Induced PancreatitisToxicities of Antimicrobial Agents Used to Treat OsteomyelitisAntiprotozoal drugsHow often does metronidazole induce pancreatitis?Biliary and Pancreatic Disease in the ElderlyDrug-Induced Acute PancreatitisExcessive Drug ChallengeRobert M. Donaldson Jr., MD 1 November 1988Volume 109, Issue 9Page: 756-757KeywordsGiardia lambliaGiardiasisGonorrheaHyperlipidemiaLiver diseasesLower back painNauseaOverweightPancreatitisPneumonia ePublished: 1 December 2008 Issue Published: 1 November 1988 PDF downloadLoading ...