Haloperidol and Torsades de Pointes
Authors: CHI-SUNG ZEE-CHENG
Journal: Annals of Internal Medicine (1985)

Letters and Corrections1 March 1985Haloperidol and Torsades de PointesCHI-SUNG ZEE-CHENG, M.D., CATHERINE E. MUELLER, Pharm.D., CHARLES F. SEIFERT, Pharm.D., HARRY R. GIBBS, M.D.CHI-SUNG ZEE-CHENG, M.D.Search for more papers by this author, CATHERINE E. MUELLER, Pharm.D.Search for more papers by this author, CHARLES F. SEIFERT, Pharm.D.Search for more papers by this author, HARRY R. GIBBS, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-102-3-418_2 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: Haloperidol, a butyrophenone, is widely used in the treatment of acute and chronic psychoses as well as in the management of agitated patients. It has been considered extremely safe at therapeutic doses of 1 to 100 mg/d (1). Cardiotoxicity has been minimal and consists of bradycardia and hypertension (2); ventricular tachyarrhythmia has not been described. To show the arrhythmogenic potential of this drug, we report the cases of two patients who developed torsades de pointes after ingestion of large doses of haloperidol in suicide attempts.A 63-year-old woman was brought to the emergency department after ingestion of...References1. SETTLE E and AYD F. Haloperidol: a quarter century of experience. J Clin Psychiatry. 1983;44:440-8. MedlineGoogle Scholar2. SCIALLI J and THORNTON W. Toxic reaction from a haloperidol overdose in two children: thermal and cardiac manifestations. JAMA. 1978;239:48-9. CrossrefMedlineGoogle Scholar3. FOWLER N, MCCALL D, CHOU T, HOLMES J, and HANENSON I. Electrocardiographic changes and cardiac arrhythmias in patients receiving psychotropic drugs. Am J Cardiol. 1976;37:223-30. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: CHI-SUNG ZEE-CHENG, M.D.; CATHERINE E. MUELLER, Pharm.D.; CHARLES F. SEIFERT, Pharm.D.; HARRY R. GIBBS, M.D.Affiliations: University of Missouri-Kansas City School of Medicine Kansas City, Missouri MO 64108-2792 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byProarrhythmic Risk with Antipsychotic and Antidepressant DrugsElectrophysiological effects of haloperidol on isolated rabbit Purkinje fibers and guinea pigs papillary muscles under normal and simulated ischemiaSedation in the mechanically ventilated patientSafety of medications used to treat acute agitationInfluence of IV Haloperidol on Ventricular Repolarization and Monophasic Action Potential Duration in Anesthetized DogsTorsade de pointes associated with the administration of intravenous haloperidol:a review of the literature and practical guidelines for useDual Rate-dependent Cardiac Electrophysiologic Effects of Haloperidol: Slowing of Intraventricular Conduction and Lengthening of RepolarizationTorsade de Pointes Associated with the Administration of Intravenous HaloperidolSedation in the intensive care unitTorsades de pointes secondary to intravenous haloperidol after coronary bypass grafting surgeryErhöhte Mortalität bei Schizophrenie und möglicher Einfluss der antipsychotischen BehandlungCytochrome P450-Mediated Drug InteractionsEffect of Ethanol, Haloperidol, and Lorezepam on Cardiac Conduction and ContractionDELIRIUMThe Association Between Intravenous Haloperidol and Torsades de PointesComplications Associated with Sedative and Neuromuscular Blocking Drugs in Critically Ill PatientsUse of Haloperidol Infusions to Control Delirium in Critically Ill AdultsTorsade de pointes caused by high-dose intravenous haloperidol in cardiac patientsAnalgesia and Sedatives in EmergenciesCardiotoxicity More Common in Thioridazine Overdose than with Other NeurolepticsIn vitro electrophysiological detection of iatrogenic arrhythmogenicityTHE SIDE-EFFECTS OF ANTIPSYCHOTIC DRUGS. II. EFFECTS ON OTHER PHYSIOLOGICAL SYSTEMSThe Effect of Haloperidol on Ventricular Fibrillation Threshold in PigsLife-Threatening Ventricular Arrhythmia (Torsades de Pointes) after Haloperidol OverdoseHaloperidol-Induced Torsades de PointesThe Hemodynamic Consequences of Pain and Its Management 1 March 1985Volume 102, Issue 3Page: 418-418KeywordsBradycardiaDrugsEmergency departmentHypertensionIngestionPsychosesSuicideTachycardia ePublished: 1 December 2008 Issue Published: 1 March 1985 PDF downloadLoading ...