tbuckley/cabot-search huggingface dataset:
Stimulator of Interferon Genes–Associated Vasculopathy With Onset in Infancy
Authors: Justine Munoz, Michel Rodière, Nadia Jeremiah, Frédéric Rieux-Laucat, Anthony Oojageer, Gillian I. Rice, Flore Rozenberg, Yanick J. Crow, Didier Bessis
Journal: JAMA Dermatology (2015)

The type I interferonopathies comprise a recently recognized group of mendelian diseases characterized by an upregulation of type I interferon signaling. These monogenic phenotypes include classic Aicardi-Goutières syndrome and syndromic forms of systemic lupus erythematosus, including familial chilblain lupus and spondyloenchondrodysplasia. Dermatologic features provide a major diagnostic clue to this disease grouping, as exemplified by the recently described stimulator of interferon genes-associated vasculopathy with onset in infancy (SAVI) caused by gain-of-function mutations in TMEM173.We describe a male child who, from the age of 2 months, had significant cutaneous disease that manifested as red violaceous plaques of the cheeks, nose, ears, fingers, and toes that progressed to gangrenous necrosis. In addition to his severe cutaneous vasculopathy, he experienced recurrent fevers, interstitial lung disease, and failure to thrive. His clinical syndrome was refractory to multiple immunosuppressive therapies. Evidence of marked upregulation of type I interferon signaling was observed in peripheral blood, and genetic testing identified a de novo germline mutation in TMEM173, confirming a diagnosis of SAVI 7 years after the onset of his disease.This observational report describes a new case of SAVI, a recently defined monogenic inflammatory phenotype, that exemplifies an emerging group of disorders related to primary upregulation of type I interferon signaling.
AN UNUSUAL CASE OF WEBER-CHRISTIAN SYNDROME
Authors: H Z POMERANTZ, M A SIMON
Journal: Annals of Internal Medicine (1957)

Case Reports1 December 1957AN UNUSUAL CASE OF WEBER-CHRISTIAN SYNDROMEHAROLD Z. POMERANTZ, M.D., MORRIS A. SIMON, M.D.HAROLD Z. POMERANTZ, M.D.Search for more papers by this author, MORRIS A. SIMON, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-47-6-1251 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe rarity of relapsing, febrile, nodular, nonsuppurative panniculitis, as well as its unknown etiology and its resistance to any specific therapy, makes every case worthy of comment and possible analysis.The case reported is of particular interest because of its onset with a single, small nodule, which made the initial diagnosis extremely difficult. The response to prednisone during six months of therapy is another feature worth noting, since only a limited number of cases reported in the literature1, 2, 3 have been so treated.CASE REPORTA 21 year old white male was admitted to hospital December 29, 1955, with...Bibliography1. Friedenberg R: Weber-Christian disease. A report of two cases, Ann. Int. Med. 38: 528-532, 1953. LinkGoogle Scholar2. DoernerNaegeleReganCameron AACFFDGF: The development of tuberculous meningitis following cortisone therapy, Am. Rev. Tuberc. 64: 564-571, 1951. MedlineGoogle Scholar3. Shuman CR: Relapsing panniculitis (Weber-Christian disease), Arch. Int. Med. 87: 669-681, 1951. CrossrefGoogle Scholar4. Duran-Reynals F: Necrotizing disease in rabbits affecting fatty and muscular tissues: analogies with Weber-Christian disease in humans, Yale J. Biol. and Med. 18: 583-594, 1946. MedlineGoogle Scholar5. De LorMartz CJRW: Weber-Christian disease with bone involvement, Ann. Int. Med. 43: 591, 1955. LinkGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Montreal,*Received for publication June 22, 1956.From the Departments of Medicine and Pathology, Jewish General Hospital, Montreal.Requests for reprints should be addressed to Harold Z. Pomerantz, M.D., Suite 705, Medical Arts Building, Montreal, Quebec, Canada. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byPanniculitisRHEUMATISM AND ARTHRITIS: REVIEW OF AMERICAN AND ENGLISH LITERATURE OF RECENT YEARS (THIRTEENTH RHEUMATISM REVIEW)*CHARLEY J. SMYTH, M.D., F.A.C.P., ROGER L. BLACK, M.D., FELIX E. DEMARTINI, M.D., IVAN F. DUFF, M.D., F.A.C.P., EPHRAIM P. ENGLEMAN, M.D., F.A.C.P., DONALD C. GRAHAM, M.D., F.R.C.P.(C), MAX M. MONTGOMERY, M.D., F.A.C.P., HOWARD F. POLLEY, M.D., F.A.C.P., EDWARD F. ROSENBERG, M.D., F.A.C.P., CARLOS F. SACASA, M.D., F.A.C.P., OTTO STEINBROCKER, M.D., HANS WAINE, M.D., GEORGE M. WILSON JR., M.D.FATAL PANNICULITIS 1 December 1957Volume 47, Issue 6Page: 1251-1256KeywordsEtiologyHospital medicine ePublished: 1 December 2008 Issue Published: 1 December 1957 PDF downloadLoading ...
Diagnostic use of recombinant Tha p 2 in the allergy to <i>Thaumetopoea pityocampa</i>
Authors: A. I. Rodríguez‐Mahillo, N. Carballeda‐Sangiao, J. M. Vega, J. C. García‐Ortiz, A. Roques, I. Moneo, M. González‐Muñoz
Journal: Allergy (2015)

Thaumetopoea pityocampa causes allergies and skin and ocular lesions. No commercial tools are currently available for the clinical diagnosis of this allergy. We aimed to develop an in vitro method for the diagnosis of this allergy to avoid patients undergoing in vivo tests with insect extracts. Recombinant Tha p 2 was produced and used in an ELISA validated with 15 allergic patients. Subsequently, 42 subjects recruited from a random sampling cross-sectional study were analysed. The ELISA sensitivity and specificity were 93.3% and 100%, respectively, for the allergic patients and 71.4% and 95.3%, respectively, for the epidemiological study. The positive ELISA results correlated with the skin prick test areas with the whole body and the setae extracts. Professional exposure and short latency of symptoms onset were risk factors for a positive result in the ELISA. In conclusion, our ELISA is very useful for T. pityocampa allergy diagnosis and for epidemiologic testing.
Abstract 3610: High stromal S100A9 expression serves an early oral cancer recurrence marker possibly through enhancing cancer cell invasivenes, angiogenesis, and differentially recruiting infiltrating immune cells
Authors: Li-Wha Wu
Journal: Cancer Research (2014)

Abstract S100A9 belongs to S100 family with Ca+2-binding EF-hands in both N- and C-termini and is frequently deregulated in several cancer types. Consistent with this notion, we identified the increase of S100A9 mRNA expression by 2.6 fold (p&amp;lt;0.01) in oral cancer cells when compared to normal oral keratinocytes using DNA microarray analysis. The increase of S100A9 protein validated in clinical tissue specimens was also detected in the adjacent tumor stroma, especially in CD15+ or CD68+ immune infiltrates. High S100A9 expression in the stroma was positively associated not only with the poor differentiation of tumor but also tumor recurrence. Moreover, high stromal S100A9 expression in early-stage patients had shorter recurrence-free survival, suggesting a role of S100A9 in oral cancer recurrence. Although altering the expression of S100A9 affected cell proliferation depending on the cell lines, S100A9 functioned as a promoting molecule for cell migration and invasion. Moreover, S100A9 secreted from oral cancer cells inhibited anti-inflammatory IL-10 production and acted as positive regulator in angiogenesis. Ectopic S100A9 expression promoted subcutaneous tumorigenesis in vivo with the enhanced recruitment of a CD11c+ myeloid cells and production of several inflammatory cytokines. The serum concentration of S100A9, a secretable protein, was significantly increased in early-stage but not late stage oral cancer patients. Together, stromal S100A9 plays a tumor-promoting role in oral carcinogenesis and serum S100A9 may serve as an early marker for cancer recurrence. Understanding the potential role of S100A9 in oral cancer and stromal cells should facilitate the development of new therapeutic approaches for oral cancer treatment. Citation Format: Li-Wha Wu. High stromal S100A9 expression serves an early oral cancer recurrence marker possibly through enhancing cancer cell invasivenes, angiogenesis, and differentially recruiting infiltrating immune cells. [abstract]. In: Proceedings of the 105th Annual Meeting of the American Association for Cancer Research; 2014 Apr 5-9; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2014;74(19 Suppl):Abstract nr 3610. doi:10.1158/1538-7445.AM2014-3610
Abstract 1487: Identification of oral carcinoma miRNA signature and control OSCC tumorigenesis through Wnt/β-catenin signaling
Authors: Wei-Min Chang, Yuan-Ming Hsu, Sung-Tau Chou, Yi-Shing Shieh, Michael Hsiao, Jenn-Ren Hsiao, Jang-Yang Chang, Shine-Gwo Shiah
Journal: Cancer Research (2014)

Abstract Aberrant microRNAs (miRNAs) expressions are often happened in cancer. In order to identify miRNAs altered in oral carcinogenesis, we investigated miRNAs and cDNA expression profiles in 40 pair-wise oral squamous cell carcinoma (OSCC) specimens. Eighty-four miRNAs were differentially expressed in the OSCC specimens compared to the matched tissue. Interestingly, 19 down-regulated miRNAs are clustered in DLK-1/Meg3 imprinted domain of chromosome 14q32.2 region. Loss of 14q32.2-miRNAs expression also raised the 14q32.2-miRNA targets expression in OSCC. We identified one target protein, Wnt-7b, was highly expressed in OSCC and regulated by miR-329 and -410. Wnt-7b increased the Wnt/β-catenin signaling activity and promoted OSCC tumor progression. Furthermore we also identify the regulation mechanism that down-regulated 14q32.2 miRNAs. Hyper-methylation in meg-3 differential methylated region (DMR) was confirmed by bisulfate sequencing. The hyper-methylation of meg-3 DMR was also induced by betel nuts extract exposure. In summary, we identified the expression signature of aberrant miRNAs in OSCC and provide a novel molecular insight how betel quid contribute to oral carcinogenesis through the epigenetic silencing of tumor suppressor miRNAs targeting the Wnt/β-catenin signaling pathway. Note: This abstract was not presented at the meeting. Citation Format: Wei-Min Chang, Yuan-Ming Hsu, Sung-Tau Chou, Yi-Shing Shieh, Michael Hsiao, Jenn-Ren Hsiao, Jang-Yang Chang, Shine-Gwo Shiah. Identification of oral carcinoma miRNA signature and control OSCC tumorigenesis through Wnt/β-catenin signaling. [abstract]. In: Proceedings of the 105th Annual Meeting of the American Association for Cancer Research; 2014 Apr 5-9; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2014;74(19 Suppl):Abstract nr 1487. doi:10.1158/1538-7445.AM2014-1487
Specific IgE antibodies in the diagnosis of atopic disease
Authors: R. Paganelli, I. J. Ansotegui, J. Sastre, C.‐E. Lange, M. H. W. M. Roovers, H. de Groot, N. B. Lindholm, P. W. Ewan
Journal: Allergy (1998)

A new immunoassay system utilizing new automatic instrumentation, new software for evaluation of data, and reagents updated for increased speed and accuracy was evaluated. Six clinical studies included 894 consecutive patients. Major symptoms were rhinoconjunctivitis, asthma, atopic dermatitis, and urticaria. The prevalence of inhalant allergy was 54–69%. Phadiatop®, detecting atopic sensitization to common inhalant allergens, agreed with clinical diagnosis in 764/836 cases (91.4%). TTie clinical sensitivity and specificity were 93% and 89%, respectively The clinical sensitivity and specificity of UniCAP specific IgE derived from 5170 comparisons with clinical diagnosis were 89% and 91 %, respectively Specific IgE measurements in UniCAP and in the Pharmacia CAP System agreed in 266/274 cases (97%). A comparison of the sensitivity and specificity of Pharmacia CAP System RAST in 1987 and with UniCAP specific IgE in 1995 showed equivalent performance without change of efficacy or degradation of IgE antibodies after 8 years. The systems were equivalent also in terms of measured values (r=0.96, slope=1.12), confirming the standardization of allergens and of assay calibration. UniCAP is an efficient laboratory system for routine diagnostic testing of allergy and a valuable tool for basic studies on allergens and antibodies.
Improving American Board of Surgery In-Training Examination Scores
Authors: Karen Deveney
Journal: JAMA Surgery (2015)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Surgery HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Surgery journal
The Acid-Base Composition of Gastric Juice During the Secretory Cycle
Authors: Theodore L. Bliss
Journal: Annals of Internal Medicine (1930)

Article1 February 1930The Acid-Base Composition of Gastric Juice During the Secretory CycleTHEODORE L. BLISS, M.D.THEODORE L. BLISS, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-3-8-838 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptMany determinations have been made of the acids and the total chlorides in the gastric secretion, but only a few of the other inorganic constituents. All observers have found that there is an increase in the concentration of the total acid and free hydrochloric acid in the normal gastric secretion following stimulation. However, observers have found differences in the response of the chlorides to stimulation. Berglund, Wahlquist and Sherwood found that the concentration of chlorides was essentially equal to that of the hydrochloric acid titrated in the secretion from a human subject having an acidity range within normal limits, after... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: The Mayo Foundation Rochester, Minnesota*This work was done under the supervision of Dr. Leonard G. Rowntree, Division of Medicine, The Mayo Clinic and The Mayo Foundation. Submitted for publication August 16, 1929. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byThe Significance of Sodium and Potassium in Gastric SecretionPotassium in Histamine-Stimulated Gastric Secretion in ManThe alkali metal ions in the organismStudies on the non-parietal component of gastric secretion in humansSur certains procédés d’épuration extra-rénale. Perfusion Intestinale et Exsanguino TransfusionGastric alkalosis with hypokalemiaThe composition of pure gastric juiceSTUDIES IN GASTRIC SECRETION 1 February 1930Volume 3, Issue 8Page: 838-849KeywordsAcidsAttentionChloridesHydrochloric acid Issue Published: 1 February 1930 PDF downloadLoading ...
National Hand Hygiene Campaigns in Europe, 2000-2009
Authors: A P Magiorakos, C Suetens, L Boyd, C Costa, R Cunney, V Drouvot, C Farrugia, M M Fernandez-Maillo, B G Iversen, E Leens, S Michael, M L Moro, C Reinhardt, R Serban, R Vatcheva-Dobrevska, K Wilson, E Heisbourg, H C Maltezou, R Strauss, K Böröcz, M Dolinšek, U Dumpis, S Erne, O Gudlaugsson, P Heczko, D Hedlova, J Holt, L Jõe, O Lyytikäinen, I Riesenfeld-Örn, M Stefkovikova, R Valinteliene, A Voss, D L Monnet
Journal: Eurosurveillance (2009)

Hand hygiene represents the single most effective way to prevent healthcare-associated infections. The World Health Organization, as part of its First Global Patient Safety Challenge, recommends implementation of multi-faceted strategies to increase compliance with hand hygiene. A questionnaire was sent by the European Centre for Disease Prevention and Control to 30 European countries, regarding the availability and organisation of their national hand hygiene campaigns. All countries responded. Thirteen countries had organised at least one national campaign during the period 2000-2009 and three countries were in the process of organising a national campaign. Although the remaining countries did not have a national campaign, several reported regional and local hand hygiene activities or educational resources on national websites.
PRIMARY JEJUNAL ULCER; REPORT OF A CASE WITH RUPTURE AND RECOVERY
Authors: F. Eugene Zemp
Journal: Annals of Internal Medicine (1939)

Case Reports1 July 1939PRIMARY JEJUNAL ULCER; REPORT OF A CASE WITH RUPTURE AND RECOVERYF. EUGENE ZEMP, M.D., F.A.C.P.F. EUGENE ZEMP, M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-13-1-188 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptPrimary jejunal ulcer is a very rare condition and differs in its clinical manifestations considerably from ulcers involving other parts of the gastrointestinal tract. Richardson1 collected 12 cases in 1922. In 1933 Ebeling2 made a survey of both domestic and foreign literature and presented a summary of the important findings in 47 collected cases and reported a case of his own. Since then Puhl,3 and Hall4 have each reported one case. Each case thoroughly studied, should add to its clinical entity.CASE REPORTE. B. R., a white male, 59 years of age, complained of pain in the lower abdomen....Bibliography1. RICHARDSON EP: Jejunal ulcer without previous gastroenterostomy, Surg., Gynec. and Obst., 1922, xxxv, 1. Google Scholar2. EBELING W: Primary jejunal ulcer, Ann. Surg., 1933, xcvii, 857. CrossrefGoogle Scholar3. PUHL H: Primary jejunal ulcer with heterotopic mucosa of the fundus, Deutsch. Ztschr. f. Chir., 1933, ccxxxix, 624. CrossrefGoogle Scholar4. HALL DP: Perforation of a primary jejunal ulcer, South. Surg., 1936, v, 309. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Columbia, S. C.*Received for publication May 10, 1938. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byBenign ulcer of the small bowel 1 July 1939Volume 13, Issue 1Page: 188-190KeywordsAbdominal painGastrointestinal tractUlcers ePublished: 1 December 2008 Issue Published: 1 July 1939 PDF downloadLoading ...
Abstract 17571: Prognostic Role of Soluble Micrornas in the Early Detection of High Platelet Reactivity and Periprocedural Myocardial Damage in Patients Undergoing Percutaneous Coronary Intervention
Authors: Annunziata Nusca, Donato Santovito, Pamela Marcantonio, Velia De Nardis, Silvia Caroli, Camilla Paganelli, Germano Di Sciascio, Francesco Cipollone
Journal: Circulation (2014)

Introduction: Despite an optimal antiplatelet strategy, high residual platelet reactivity (HRPR) is associated with an increased risk of procedural myocardial infarction (PMI) in patients undergoing percutaneous coronary intervention (PCI). MicroRNAs (miR), small non-coding RNA molecules, play a significant role in vascular and platelet pathways by modulating several transcription factors. However, nowadays, few clinical studies has been conducted to evaluate the prognostic role of microRNAs in patients undergoing PCI. Hypothesis: Thus, we aimed to analyze possible role of these molecules on platelet aggregation and PMI development in such patients. Methods: To-date we enrolled 23 patients. Blood samples were collected for detection of cardiac markers (troponin I and creatine kinase-MB) and microRNAs extraction. RT-quantitative PCR was performed and relative quantification of miR expression calculated with the 2-ΔΔCt method. Platelet reactivity was measured by the VerifyNow P2Y12 assay and HRPR was define...
Parvovirus B19 and Onset of Juvenile Dermatomyositis
Authors: Gulnara Mamyrova, Lisa G Rider, Laura Haagenson, Susan Wong, Kevin E Brown
Journal: JAMA (2005)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Serious and Unstable Condition: Financing America's Health Care
Authors: Henry J. Aaron
Journal: Annals of Internal Medicine (1991)

The United States spends more on health care than any other nation in the world, yet millions of Americans cannot afford basic care for acute illnesses, few are insured against the costs of long-term care, and many frequently used medical procedures have never been fully evaluated. The goals of controlling spiraling health care costs and extending insurance coverage or even maintaining current insurance coverage seem to be in conflict. But progress can be made on both goals if they are tacked together. Henry Aaron evaluates these critical issues and explores how adequate care can be provided without fueling inflation. Because the current arrangements for financing America's health care cannot endure, Aaron contends that a major national debate on the restructuring of the U.S. system of financing health care is inescapable, and major legislation is likely. Serious and Unstable Condition offers a guide that is crucial to understanding the reform debate. It explains the important economic issues of health care as a background for evaluating both the current system and proposals for change. Aaron compares the U.S. system of health care financing with certain foreign systems and reviews major options for reform. He cautions that unless the health insurance system is radically changed, the number of uninsured will continue to increase and costs will continue to escalate. He then offers his own comprehensive plan to address these problems.
The Rehabilitation Specialist's Handbook
Authors: Jules M. Rothstein
Journal: Annals of Internal Medicine (1991)

Americans with Disabilities Act and Accessibility Issues (Including Wheelchair Information) Musculoskeletal Anatomy, Orthopedics, and Orthopedic Therapy Neuroanatomy, Neurology, and Neurologic Therapy Pulmonary Anatomy and Pulmonary Therapy Vascular Anatomy, Cardiology, and Cardiac Rehabilitation Pediatrics Geriatrics Measurement, Assessment, and Outcomes Kinesiology and Gait Prosthetics and Orthotics Psychology and Psychiatry Electromagnetic, Thermal Modalities and Electrotherapy Massage and Soft-Tissue Techniques General Medicine (Including Oncology and AIDS) Pharmacology Burns Reference Tables and Conversion Charts Translations: Useful Expressions Appendix: First Aid