tbuckley/cabot-search huggingface dataset:
The characteristic sequence for the onset of contraction in the normal human left ventricle.
Authors: P D Clayton, W F Bulawa, S C Klausner, P M Urie, H W Marshall, H R Warner
Journal: Circulation (1979)

The sequence for the onset of segmental contraction of the left ventricle was studied in 25 normal patients by analyzing sequential frames obtained at 16.7-msec intervals of right anterior oblique (RAO) ventriculograms by two independent methods. In the first method, we compared the times of onset of contraction of the hemidiameters associated with each of 54 segments with time of onset of contraction of the average of all the hemidiameters for the ventricular contour. In the second method we used a radial coordinate system and determined relative phase relationships by plotting the motion of each of 54 segments against the average motion of all segments. The resulting pattern showed that, on the average, the midregion of the inferior wall began to contract 25 msec before the apex and the midregion of the anterior wall began contraction 18 msec before the apex. In 12 of 25 patients the interior and anterior walls both began to contrast before the apex. In only one of 25 patients did the apex begin to contract first. This sequences of contraction corresponds to the reported sequence of electrical activation for normal human left ventricles.
Extended Haplotype in the Tumor Necrosis Factor Gene Cluster Is Associated with Asthma and Asthma-related Phenotypes
Authors: Adrienne G. Randolph, Christoph Lange, Edwin K. Silverman, Ross Lazarus, Scott T. Weiss
Journal: American Journal of Respiratory and Critical Care Medicine (2005)

Tumor necrosis factor is a proinflammatory cytokine found in increased concentrations in asthmatic airways. The TNF-alpha (TNF) and lymphotoxin-alpha (LTA) genes belong to the TNF gene superfamily located within the human major histocompatibility complex on chromosome 6p in a region repeatedly linked to asthma. The TNF position -308 and LTA NcoI polymorphisms are believed to influence TNF transcription and secretion, respectively.
510 Viral resistance to adefovir therapy results from reappeared wild type hepatitis B virus in majority of patients with YMDD mutants
Authors: S.H. Ryu, Y.-H. Chung, J.A. Kim, M.H. Choi, Y.-S. Lee, S.W. Jung, D.D. Suh, H.J. Min, M.K. Janes, S.H. Kim, K.M. Kim, Y.S. Lim, Y.S. Lee, D.J. Suh
Journal: Journal of Hepatology (2006)
Please, sir, I want some more
Authors: L Smith, S J Thornton, J Reinarz, A N Williams
Journal: BMJ (2008)

Fictional “truth” doesn’t always coincide with fact, find L Smith and colleagues 

The plaintive words of the unfortunate boy chosen to plead for his fellow inmates still resonate. They speak of chronic want, injustice, and neglect. But how true are the sentiments underpinning this powerful popular work? A dietetic analysis of Oliver Twist’s workhouse diet, as well as contemporaneous workhouse menus, allows us to answer the question—did Oliver really need more?

Today's children try out the Oliver Twist diet in a 10 minute video, which also includes interviews with this paper's authors.

In the past few decades, historians have described workhouses as “pauper palaces.”[1] Yet others have highlighted the barbarous injustices perpetrated on inmates, most notably at Andover workhouse, where paupers were reduced to gnawing rotten bones. Terrifying rumours of floggings, starvation, and the separation of families circulated in contemporary society. Dickens was mainly responsible for the dim view of the Victorian workhouse—the Andover guardians were condemned by a select committee nine years after the publication of Oliver Twist, or, the Parish Boy’s Progress (1837-8).[2] 

In Oliver Twist , Charles Dickens wrote damningly about the workhouse and the plight of Victorian children. Oliver was born in a workhouse, almost immediately orphaned, and then abandoned. He survived his first nine years at a “baby farm,” where eight in 10 children perished.[3] He then entered a workhouse where comforts at best approached the lowest levels that could support existence. Oliver remained there for three months until he was ejected for “ingratitude” after his request for more food.

Dickens describes Oliver’s diet as “three meals of thin gruel a day, with an onion twice a week and half a roll on Sunday.” On feast days, the inmates received an extra two and a quarter ounces (60 g) of bread. …
Severe hemolytic anemia due to cold agglutinin complicating untreated chronic hepatitis C: Efficacy and safety of anti‐CD20 (rituximab) treatment
Authors: Anne Etienne, Stéphane Gayet, Florian Vidal, Pascale Poullin, Corinne Brunet, Jean‐Robert Harlé, Gilles Kaplanski
Journal: American Journal of Hematology (2004)

Abstract Autoimmune hemolytic anemia (AIHA) is rare and difficult to treat during chronic hepatitis C. We report herein the case of a hepatitis C patient with severe and resistant AIHA who experienced a good and sustained response with anti‐CD20 monoclonal antibody treatment. Am. J. Hematol. 75:243–245, 2004. © 2004 Wiley‐Liss, Inc.
Depressive Symptoms in the Community
Authors: Scott Howard Frank
Journal: JAMA (1992)

<h3>To the Editor.</h3> —As a primary care physician, I congratulate Johnson et al on their article, "Service Utilization and Social Morbidity Associated With Depressive Symptoms in the Community."<sup>1</sup>Their careful documentation of the clinical importance of depressive symptoms demonstrates the inadequacy of current psychiatric labeling to identify the spectrum of mental health problems confronting primary care. It is simple common sense to recognize that depression occurs over a continuum rather than in dichotomy as implied by diagnostic labels. By imposing the diagnostic dichotomy, we discount the distress experienced by most primary care patients as trivial or unimportant and risk undervaluing sociocultural factors that don't fit into the biomedical model.<sup>2</sup> I question, however, labeling fewer depressive symptoms as "subclinical" depression, since this designation implies that the diagnosis is hidden, difficult to detect, or "without clinical manifestation."<sup>3</sup>In fact, these patients are defined by symptoms that are easily elicited.
Skin stimulation, objects of perception, and the blind
Authors: Barry Hughes
Journal: Behavioral and Brain Sciences (2007)

Abstract The model developed in the target article is not as comprehensive as might be desired on two counts: (1) in that how the transition from proximal stimulation at the skin gives rise to the perception of external objects is taken for granted; and (2) in that another population of participants, the blind, constitute an important group from which we can understand somatosensory processing and neural plasticity.
New Topical Therapy for Acne Rosacea Offers Conspicuous Improvement, No Systemic Effects
Authors: Marsha F. Goldsmith
Journal: JAMA (1989)

RED-NOSED "BABY BOOMERS" are now less likely to become a serious threat to the aesthetics of American life, thanks to recent Food and Drug Administration (FDA) approval of Metro-Gel, the first product specifically developed to treat acne rosacea. Metro-Gel (metronidazole, 0.75% topical gel) was developed by Curatek Pharmaceuticals, Elk Grove Village, Ill. Rosacea, a dermatologic disease whose etiology is unknown, typically affects fair-skinned men and women in their 30s and 40s who flush or blush easily. The red patches on forehead, cheeks, nose, and chin that typify the disorder wax and wane for reasons not understood. But spontaneous remission is rare and the problem generally worsens without treatment. <h3>Ah, yaaas...</h3> Commonly called "adult acne," the disease is characterized by the progressive development of erythema, telangiectasia, edema, papules and pustules, and finally rhinophyma, the bright pink proboscis that was prominent on bibulous-acting comedian W. C. Fields. This typical feature is probably
The effects of the GABA agonist, baclofen, on sleep and breathing
Authors: AJ Finnimore, M Roebuck, D Sajkov, RD McEvoy
Journal: European Respiratory Journal (1995)

The gamma aminobutyric acid (GABA)-B agonist, baclofen, is a centrally-acting, anti-spasmodic agent and muscle relaxant used in spinal cord lesions, multiple sclerosis and other neurological disorders. In a previous pilot study of quadriplegic patients, 75% of whom were treated with baclofen, we found a high prevalence of sleep-disordered breathing. Because of the depressant effects of GABA on the central nervous system, we hypothesized that baclofen might aggravate sleep-disordered breathing in susceptible individuals by depressing central ventilatory drive, increasing upper airway obstruction and/or increasing the arousal threshold to apnoea. We therefore conducted a double-blind, placebo-controlled, cross-over study of baclofen 25 mg, administered before sleep in 10 snorers with mild sleep-disordered breathing (respiratory disturbance index &lt; 30 events per sleep hour). Each subject underwent two standard polysomnographic assessments, one week apart. Total sleep time was significantly prolonged by baclofen (placebo 356 +/- 9.9 SEM min; baclofen 386 +/- 9.9 min). Both nonrapid eye movement(REM) and REM sleep duration were increased (nonREM: placebo 295 +/- 6.8 min; baclofen 311 +/- 8.9 min; REM: placebo 61 +/- 7.5 min; baclofen 76 +/- 9.0 min). Time spent awake after sleep onset was reduced after baclofen (placebo 71 +/- 10.3 min; baclofen 51 +/- 9.7 min). There was a slight reduction in mean overnight oxygen saturation (placebo 95.2 +/- 0.5%; baclofen 94.4 +/- 0.7%). The frequency of apnoeas plus hypopnoeas (respiratory disturbance index (RDI)) did not change significantly (placebo 9 +/- 1.8 events.h-1; baclofen 13 +/- 3.4 events.h-1).(ABSTRACT TRUNCATED AT 250 WORDS)
Endoscopic Ultrasound Diagnosis of Liesegang Rings
Authors: T. Yusuf, M. Levy
Journal: Endoscopy (2006)

Liesegang rings are rare, acellular, spherical to elongated, concentrically laminated, ring-like structures that range from 5 microns to 820 microns in diameter [1] [2]. They are nonpolarizeable and are characterized by faint radial striations and an amorphous central core [3]. Liesegang rings are most commonly identified in areas of hemorrhage, inflammation, or necrosis, and in renal and perirenal cysts, and can be mistaken for parasites such as the giant kidney worm, Dioctophyma renale [4] [5]. We describe the first known case of Liesegang rings diagnosed by endoscopic ultrasound-guided fine-needle aspiration.
878. Overexpression of Fibromodulin Inhibits Neointima Formation in Cultured Human Saphenous Veins
Authors: Parisa Ranjzad, Husein K. Salem, Paul A. Kingston
Journal: Molecular Therapy (2006)

Introduction: The success of coronary artery bypass grafting (CABG) is limited by poor long-term graft patency. Saphenous vein (SV) is the most commonly used conduit for CABG with a high failure rate due to intimal thickening and superimposed atherosclerosis. In the absence of any effective pharmacological therapies, late vein graft failure has been identified as a putative target for gene therapy. Two small leucine-rich proteoglycans, decorin and fibromodulin, possess TGF-|[beta]|1-antagonist activity in vitro and in vivo. Local overexpression of decorin reduces neointima formation in response to arterial injury in animal models. However fibromodulin is a more effective competitor for TGF-|[beta]| binding than decorin. The purpose of this study was to evaluate the ability of adenoviral-mediated gene transfer of bovine fibromodulin to inhibit neointima formation in an ex vivo model of vascular injury.
For-profit companies will strip NHS assets under proposed reforms
Authors: L. Reynolds
Journal: BMJ (2011)

The unfolding cautionary tale of Southern Cross illustrates the fundamental problems with the outsourcing of public services to corporate bodies ( BMJ 2011;342:d3535, doi:10.1136/bmj.d3535). Its crisis originated when it was bought by private equity firms, which buy companies, like Southern Cross, that own unmortgaged land and buildings. After selling, leasing back, or borrowing against these assets, they dispose of the company, now saddled with debt. Their aim is to extract rather than to add value. Any publicly listed company may be a target because its shares can be acquired on the stock market.

Southern Cross is now threatened by insolvency. Despite pre-existing concerns about inadequate staffing levels, it claims it can cut 3000 frontline posts without harming quality of care. If this is true, the company has previously been charging councils, and residents who fund their own care, for unnecessary staff. The directors have announced cuts in nursing, catering, and cleaning jobs, but not in management pay rates, where savings would not further prejudice care standards.

The reason that any commercial enterprise exists is to make profits, and the over-riding duty of the directors, enshrined in company law, is to maximise the money the company generates for its …
The Deregulatory Effects of Preempting Tort Litigation
Authors: Lawrence O. Gostin
Journal: JAMA (2008)

CHARLES RIEGEL UNDERWENT CORONARY ANGIOplasty in 1996, shortly after sustaining a myocardial infarction. Mr Riegel’s physician inserted the Evergreen balloon catheter, a medical device approved by the US Food and Drug Administration (FDA), into his patient’s coronary artery in an attempt to dilate the artery, but the catheter ruptured. Mr Riegel developed complete heart block, was placed on life support, and underwent emergency coronary artery bypass graft surgery. He sued Medtronic, the manufacturer of the device, alleging that the company was liable under New York tort law in designing, testing, inspecting, labeling, and marketing the catheter. On February 20, 2008, the Supreme Court held that the Medical Device Amendments of 1976 (MDA) bars common law claims challenging the safety or effectiveness of a medical device marketed in a form that received premarket approval from the FDA. Riegel v Medtronic Inc has broad implications for patient safety because it removes all means of judicial recourse for most consumers injured by defective medical devices.
Dyspepsia in general practice.
Authors: P J Shorvon
Journal: BMJ (1990)

study.Similar high figures have been found for the whole South Western region (2 64/1000 in 1987; data provided by the regional information unit).The reason for the high incidence of the syndrome in Avon is unclear but may in part be due to the fact that equivocal findings are less likely to be recorded as a cause of death.If government recommendations to establish a paediatric patholo- gist in each region are implemented the difference between the incidence in Avon and elsewhere may diminish.
Blood pressure regulates platelet-derived growth factor A-chain gene expression in vascular smooth muscle cells in vivo. An autocrine mechanism promoting hypertensive vascular hypertrophy.
Authors: N Negoro, Y Kanayama, M Haraguchi, N Umetani, M Nishimura, Y Konishi, J Iwai, M Okamura, T Inoue, T Takeda
Journal: Journal of Clinical Investigation (1995)

To clarify the role of PDGF A-chain in hypertensive vascular hypertrophy of spontaneously hypertensive rats (SHRs), we studied levels of PDGF A-chain gene expression and transcription factors related to the gene in vascular smooth muscle cells (VSMCs) of SHRs in vivo. RNase protection assay and in situ hybridization showed that PDGF A-chain mRNA levels in VSMCs of SHRs were twofold higher than in those of normotensive Wistar-Kyoto rats. Gel retardation assays showed that levels of Sp1 and AP-2 in VSMCs of SHRs were twofold more abundant than in those of Wistar-Kyoto rats. Treatment with four pharmacologically different species of antihypertensive drugs for 2 wk decreased the levels of both PDGF A-chain mRNA and Sp1, but not AP-2 level in VSMCs of SHRs with regression of aortic hypertrophy, indicating that increases in levels of both PDGF A-chain mRNA and Sp1 in VSMCs of SHRs were associated with high blood pressure. These results suggest that high blood pressure is a stimulus which upregulates PDGF A-chain gene expression in VSMCs of SHRs, resulting in an autocrine enhancement in hypertensive vascular hypertrophy, and that the activation of the gene may be mediated through increases in Sp1 in these cells.
New consultant contract has improved the quality of care, BMA claims
Authors: Andrew Cole
Journal: BMJ (2006)

Short term financial cuts in some trusts in England are threatening the major gains brought by the new consultant contract, the BMA warned at the latest hearing of the parliamentary health select committee into workforce planning.

The deputy chairman of the BMA's consultants' committee, Jonathan Fielden, said that the new contract had fostered collaboration between consultants and managers and helped make dramatic improvements in some areas of work, such as meeting emergency department targets and cutting numbers of cancelled operations.

“Unfortunately, that partnership is put under stress by centrally driven short term measures,” said Dr Fielden. “Where relations are fractured you will …
Prognostic impact of tumor location in stage IV colon cancer: A propensity score analysis in a multicenter study
Authors: Soichiro Ishihara, Takeshi Nishikawa, Toshiaki Tanaka, Junichiro Tanaka, Tomomichi Kiyomatsu, Kazushige Kawai, Keisuke Hata, Hioaki Nozawa, Takamitsu Kanazawa, Shinsuke Kazama, Hironori Yamaguchi, Eiji Sunami, Joji Kitayama, Yojiro Hashiguchi, Kenichi Sugihara, Toshiaki Watanabe
Journal: International Journal of Surgery (2014)
Third-Generation SERMs May Face Uphill Battle
Authors: C. Schmidt
Journal: JNCI Journal of the National Cancer Institute (2010)

Lasofoxifene, a third-generation selective estrogen receptor modulator (SERM), has emerged from the phase III PEARL trial with what could be considered flying colors. Compared with placebo, the drug reduced breast cancer risk in postmenopausal women with osteoporosis as effectively as firstgeneration tamoxifen and second-generation raloxifene, prevented more kinds of fractures than raloxifene, and did not raise the risk of endometrial cancer like tamoxifen. As reported in this issue of the Journal, lasofoxifene was particularly effective in reducing risk in higherrisk women and those with high estradiol levels. But don’t look for lasofoxifene as an immediate option in breast cancer chemoprevention. The drug, made by Pfi zer, has approval in Europe, but only as an osteoporosis treatment. In the U.S., the company has withdrawn its application to the Food and Drug Administration despite the PEARL trial results. According to its most recent fi ling with the Securities and Exchange Commission, in August, Pfi zer is now “exploring strategic options for [lasofoxifene], including but not limited to out-licensing or sale.”
Recurrent facial oedema associated with a silicone-rubber implant
Authors: MARION I. WHITE, LOUISE M. SMART, DIANA M. MACGREGOR, C.R.W. RAYNER, F.W. SMITH
Journal: British Journal of Dermatology (1991)

Journal Article Recurrent facial oedema associated with a silicone‐rubber implant Get access MARION I. WHITE, MARION I. WHITE Department of Dermatology, Aberdeen Royal infirmary. Aberdeen, U.K. Dr Marion I. White, Ward 29. Foresterhill, Aberdeen Royal Infirmfary. Aberdeen AB9 2ZB, U.K. Search for other works by this author on: Oxford Academic Google Scholar LOUISE M. SMART, LOUISE M. SMART Department of Pathology. University of Aberdeen. Aberdeen. U.K. Search for other works by this author on: Oxford Academic Google Scholar DIANA M. MACGREGOR, DIANA M. MACGREGOR Department of Dermatology, Aberdeen Royal infirmary. Aberdeen, U.K. Search for other works by this author on: Oxford Academic Google Scholar C.R.W. RAYNER, C.R.W. RAYNER Department of Plastic Surgery, Aberdeen Royal infirmary. Aberdeen, U.K. Search for other works by this author on: Oxford Academic Google Scholar F.W. SMITH F.W. SMITH Department of Nuclear Medicine, Aberdeen Royal infirmary. Aberdeen, U.K. Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 125, Issue 2, 1 August 1991, Pages 183–185, https://doi.org/10.1111/j.1365-2133.1991.tb06069.x Published: 01 August 1991
Association Between Leukocyte Telomere Length and Drug-Eluting Stent Strut Coverage by Optical Coherence Tomography
Authors: Ehrin J. Armstrong, Lei Xing, Jianzhong Zhang, Yanhua Zheng, Kendrick A. Shunk, Robert W. Yeh, Ramin Farzaneh-Far, Bo Yu, Ik-Kyung Jang
Journal: Journal of the American College of Cardiology (2012)
'Ivory Vertebra' in Hodgkin's Disease
Authors: Marjorie Hertz
Journal: JAMA (1977)

BONE involvement in Hodgkin's disease does not usually occur in its early stage.<sup>1</sup>The "ivory" appearance of the vertebra is the result of a purely sclerotic change in the bone. This occurs in 10% to 15% of cases. Local pain, when present, may disappear following radiation therapy. However, the response of the ivory vertebra to therapy has not received wide comment. We report the case of a patient with Hodgkin's disease who had an ivory vertebra. Following radiation therapy, the bone was completely restored to its normal architecture. <h3>Report of a Case</h3> A 23-year-old man had had back pain of several months' duration. Examination showed enlarged supraclavicular lymph glands. A biopsy specimen from a lymph gland showed nodular sclerotic Hodgkin's disease. A chest roentgenogram was normal. In May 1974, lymphangiography was performed. No pathologic findings were noted at that time. However, the 11th dorsal vertebra was found to be
Liver and Biliary Diseases
Authors: Donald M. Jensen
Journal: JAMA (1993)

This is the first edition of<i>Liver and Biliary Diseases</i>, a multiauthored text edited by Neil Kaplowitz, MD. As such, it joins a prestigious library of other textbooks in this rapidly evolving field. What is it, therefore, that sets this book apart from the others? Although<i>Liver and Biliary Diseases</i>is comprehensive, at 732 pages it is considerably more concise and readable than many of the other more exhaustive texts. It is primarily aimed at a general audience of physicians in training, internists, and gastroenterologists, but even hepatologists may find the many tables and graphics useful for quick reference. Among the most attractive features of the book is way each chapter is formatted. Within each subsection, important facts are highlighted in bold print to facilitate quick review. The reference section at the end of each chapter contains an annotated bibliography of only the most important works and review articles, rather
Four-Dimensional Cardiac Image by Helical Computed Tomography
Authors: Yasushi Koyama, Hiroshi Matsuoka, Hiroshi Higasino, Hideo Kawakami, Katsuji Inoue, Taketoshi Ito, Masaya Doi, Sigeru Nakata, Teruhito Mochizuki
Journal: Circulation (1999)

U ltrasound and MRI are useful in assessing wall motion and systolic thickening with 2D images.Volumetric data of the helical CT provide frozen 3D images.We sought to determine whether helical CT could assess left ventricular wall motion with 3D animation.We have developed a new cardiac application, ventriculography by 4D enhanced helical CT (4D-CT-VG), which can assess wall motion with 3D animation from any perspective.We demonstrate representative 4D-CT-VG in 3 patients with acute myocardial infarction.In all 3 patients, akinetic areas assessed by 4D-CT-VG were concordant with those evaluated by conventional left ventriculography (LVG) (Figure).
Some countries will not achieve millennium development goals for health by 2015, WHO says
Authors: Owen Dyer
Journal: BMJ (2005)

The UN's millennium development goals on maternal and child health will not be met unless dozens of countries swiftly create national maternal and child health services with universal access, according to the World Health Organization's 2005 World Health Report .

The report, which was published last week to coincide with world health day (7 April), estimates that each year 3.3 million babies are stillborn, more than four million die in their first month of life, and a further 6.6 million children die before the age of five years. The number of women dying each year as a result of pregnancy, abortion, or childbirth …