ACQUIRED FIBRINOGEN DEFICIENCY ASSOCIATED WITH CARCINOMA OF THE BRONCHUS
Authors: J R FOUNTAIN, R L HOLMAN
Journal: Annals of Internal Medicine (1960)

Case Reports1 February 1960ACQUIRED FIBRINOGEN DEFICIENCY ASSOCIATED WITH CARCINOMA OF THE BRONCHUSJ. R. FOUNTAIN, M.D., M.R.C.P. (Edin.), R. L. HOLMAN, M.B., Ch.B.J. R. FOUNTAIN, M.D., M.R.C.P. (Edin.)Search for more papers by this author, R. L. HOLMAN, M.B., Ch.B.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-52-2-459 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptCarcinoma may lead to anemia, leukopenia, thrombocytopenia and the appearance of a leuko-erythroblastic blood picture, but only in rare instances have disorders of blood coagulation been observed. Stefanini1 and Cosgriff and Leifer2 have recorded cases of Factor V deficiency associated with advanced carcinoma, while Jürgens and Trautwein3 and, more recently, Swan and his associates,4 have reported a severe hemorrhagic diathesis due to fibrinogen deficiency in patients with advanced carcinoma of the prostate.It is the purpose of this paper to report the occurrence of a bleeding disorder due to fibrinogen deficiency in a patient with bronchial carcinoma.CASE REPORTA...Bibliography1. Stefanini M: Activity of plasma labile factor in disease, Lancet 1: 606, 1951. CrossrefMedlineGoogle Scholar2. CosgriffLeifer SWE: Factor V deficiency in hemorrhagic diathesis (parahemophilia), J. A. M. A. 148: 462, 1952. CrossrefMedlineGoogle Scholar3. JürgensTrautwein RH: Uber Fibrinopenie (Fibrinogenopenie) beim Erwachsenen nebst Bemerkungen über die Herkunft des Fibrinogens, Deutsches Arch. f. klin. Med. 169: 28, 1930. Google Scholar4. SwanWoodDaniel HTKFO: Dangerous bleeding associated with carcinoma of prostate, Brit. M. J. 1: 495, 1957. CrossrefMedlineGoogle Scholar5. BiggsMacFarlane RRG: Human blood coagulation and its disorders, 2nd Ed., 1957, Blackwell, Oxford, England. Google Scholar6. YeagerRhoadsFreeman LBPSS: Fibrinogen deficiency: clinical features and probable etiologic factors, J. Lab. and Clin. Med. 32: 502, 1947. MedlineGoogle Scholar7. AlliboneBaar ECHS: Fibrinogen deficiency as a factor in hemorrhagic disease, Arch. Dis. Childhood 18: 146, 1943. CrossrefMedlineGoogle Scholar8. OpitzSilberberg HM: Afibrinogenämie und Thrombopenie infolge ausgedehntei hepato-lienaler Tuberkulose, Klin. Wchnschr. 2: 1443, 1924. CrossrefGoogle Scholar9. Risak E: Die Fibrinopenie, Ztschr. f. klin. Med. 128: 605, 1935. Google Scholar10. TagnonWhitmoreSchulmanKravitz HJWFPSC: The significance of fibrinolysis occurring in patients with metastatic cancer of the prostate, Cancer 6: 63, 1953. CrossrefMedlineGoogle Scholar11. TagnonSchulmanWhitmoreLeone HJPWFLA: Prostatic fibrinolysis. Study of a case illustrating role in hemorrhagic diathesis of cancer of the prostate, Am. J. Med. 15: 875, 1953. CrossrefMedlineGoogle Scholar12. WeinerReidRoby AEDECC: Incoagulable blood in severe premature separation of the placenta: a method of management, Am. J. Obst. and Gynec. 66: 475, 1953. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Leeds,*Received for publication June 16, 1958.From the Department of Medicine, General Infirmary, Leeds, England.Requests for reprints should be addressed to J. R. Fountain, M.D., Department of Medicine, The General Infirmary, The University of Leeds, Leeds, 1, England. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byThromboembolic complications associated with brain tumorsFibrinogen kinetics in patients with neoplastic diseaseChronic diffuse intravascular coagulation (DIC) in nonmetastatic ovarian cancerBLEEDING AND INTRAVASCULAR CLOTTING IN MALIGNANCY: A REVIEWParaneoplastic syndromes Resulting from elaboration of ectopic hormones, antigens and bizarre toxinsReferenceExtrapulmonary effects of cancer of the lung and pleuraDefibrination syndrome associated with bronchial carcinomaCoagulation disorders in cancer. III.Fibrinolysis and inhibitorsAcute fatal fibrinolysis with gastric carcinomaA review of unusual systemic manifestations associated with carcinomaSymptomatische Afibrinogen�mieFibrinolyse als Blutungsursache beim metastasierenden Magencarcinom 1 February 1960Volume 52, Issue 2Page: 459-463KeywordsAnemiaBloodBlood coagulationFibrinogenHemorrhagePatientsThoraxTuberculosis ePublished: 1 December 2008 Issue Published: 1 February 1960 PDF downloadLoading ...