Complications with Christmas Factor (Factor IX) Concentrates
Authors: Gary L. Grammens, Robert T. Breckenridge
Journal: Annals of Internal Medicine (1974)

Letters1 May 1974Complications with Christmas Factor (Factor IX) ConcentratesGARY L. GRAMMENS, PH.D., M.D., ROBERT T. BRECKENRIDGE, M.D., F.A.C.P.GARY L. GRAMMENS, PH.D., M.D.Search for more papers by this author, ROBERT T. BRECKENRIDGE, M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-80-5-666 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: Several reports of thromboembolic complications after the use of factor IX concentrates have recently appeared (1-3). These reports have prompted us to survey our experience with the products during the past 4 years*.During this period, 1984 vials of Konȳne® (Cutter Laboratories, Berkeley, California) and 57 vials of Proplex® (Hyland Laboratories, Costa Mesa, California) were used in treating 15 patients with Christmas disease (factor IX deficiency), (Table 1). Most of the treatment episodes required only outpatient care, with the use of small amounts of concentrate for short periods; however, there were seven events in which patients required...References1. CEDERBAUMROBERTS AH: Complications of the use of prothrombin complex concentrates in liver disease (abstract). Clin Res 21:92, 1973 Google Scholar2. KASPER C: Postoperative thromboses in hemophilia B (letter). N Engl J Med 289:160, 1973 CrossrefMedlineGoogle Scholar3. STEINBERGDREILING MB: Vascular lesions in hemophilia B (letter). Ibid., p. 592 Google Scholar4. EDELL S: Anaphylaxis after Konȳne (letter). N Engl J Med 285:580, 1971 CrossrefMedlineGoogle Scholar5. WEINREBMINSKY NN: Serious reaction after Konȳne (letter). Ibid., pp. 1151-1152 Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Department of Medicine University of Rochester School of Medicine and Dentistry Rochester, New York 14621*This work was supported by a U.S. Public Health Service training grant. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byProthrombin Complex Concentrates for Clinical UsePROTHROMBIN COMPLEX CONCENTRATES: CLINICAL USE*Factor IX and thrombosisDisseminated Intravascular Coagulation and Blood Component TherapyIntravascular Coagulation with Use of Human Prothrombin Complex ConcentratesANDREW I. CEDERBAUM, M.D., PHILIP M. BLATT, M.D., HAROLD R. ROBERTS, M.D.Prothrombin complex concentrate: Use in controlling the hemorrhagic diathesis of chronic liver diseaseThe Use of Factor IX Concentrates for Patients with Conditions other than Factor IX DeficiencyFactor IX Deficiency in the Nephrotic Syndrome: Studies with Prothrombin Complex ConcentrateThrombogenic Materials in Prothrombin Complex ConcentratesPHILIP M. BLATT, M.D., ROGER L. LUNDBLAD, Ph.D., HENRY S. KINGDON, M.D., Ph.D., GEORGE McLEAN, M.D., HAROLD R. ROBERTS, M.D.Prothrombin Complex Preparations: A Cautionary NoteOSCAR D. RATNOFF, M.D. 1 May 1974Volume 80, Issue 5Page: 666-667KeywordsHemophilia BMedical servicesOutpatients ePublished: 1 December 2008 Issue Published: 1 May 1974 PDF downloadLoading ...