tbuckley/cabot-search huggingface dataset:
Ventricular function and contractile proteins in the infarcted overloaded rat heart
Authors: D. L Geenen, A. Malhotra, D. Liang, J. Scheuer
Journal: Cardiovascular Research (1991)

Study objective – The aim was to determine whether surviving myocardium in the infarcted rat heart retains the ability to respond to sustained increases in afterload. Design – Cardiac mass, ventricular function, and actomyosin ATPase activity were compared in animals subjected to coronary artery ligation to produce infarction, superimposed renal artery constriction 4 weeks after infarction, and in sham operated animals. Experimental material – Female Wistar rats obtained at 10 weeks of age (200-225 g) were used for the studies. Measurements and main results – Four weeks after coronary artery ligation, infarcted hearts showed a 22% increase in heart weight and a significant reduction in peak systolic pressure and +/- dP/dt during acute volume infusion and aortic occlusion compared to sham operated hearts. Eight weeks after the initial surgical intervention, the infarct group showed significant impairment in ventricular performance compared to the sham operated group but no further decrement was observed between hearts with infarction and those with infarct and superimposed renal artery constriction for peak systolic pressure and +/- dP/dt during volume infusion and aortic occlusion. Actomyosin ATPase activity, however, was depressed and the shift to V3myosin isoenzyme was greater in infarct and renal artery constriction compared to infarct alone. Conclusions – Left ventricular myocardium following infarction does not retain the ability to increase cardiac mass and shows depressed levels of actomyosin ATPase activity when exposed to a superimposed chronic afterload from renal artery constriction. However, cardiac function in situ is maintained.
Communicating End-of-Life Decisions
Authors: Brendan M. Reilly
Journal: Annals of Internal Medicine (1998)

Letters15 February 1998Communicating End-of-Life DecisionsBrendan M. Reilly, MDBrendan M. Reilly, MDCook County Hospital; Chicago, IL 60612Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-128-4-199802150-00018 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:Hofmann and colleagues [1] observed that in their experience “a majority of seriously ill inpatients had not discussed and were not interested in discussing preferences for cardiopulmonary resuscitation (58%) …” and contrasted their results with ours (only 19% of our patients could be so categorized) [2]. Because the authors do not discuss possible reasons for these differences, I would like to propose a few.First, I believe that the authors have incorrectly summarized their own findings. Among their 1589 respondents, 366 (23%) had previously discussed cardiopulmonary resuscitation preferences and another 516 (32%) hadn't but wanted to. Thus, ...References1. Hofmann JC, Wenger NS, Davis RB, Teno J, Connors AF Jr, Desbiens N, et al. Patient preferences for communication with physicians about end-of-life decisions. Ann Intern Med. 1997; 127:1-12. Google Scholar2. Reilly BM, Magnussen CR, Ross J, Ash J, Papa L, Wagner M. Can we talk? Inpatient discussions about advance directives in a community hospital. Attending physicians' attitudes, their inpatients' wishes, and reported experience. Arch Intern Med. 1994; 154:2299-308. Google Scholar3. Reilly BM, Wagner M, Magnussen CR, Ross J, Papa L, Ash J. Promoting inpatient directives about life-sustaining treatments in a community hospital. Results of a 3-year time-series intervention trial. Arch Intern Med. 1995; 155:2317-23. Google Scholar4. A controlled trial to improve care for seriously ill hospitalized patients. The study to understand prognoses and preferences for outcomes and risks of treatment. The SUPPORT Principal Investigators. JAMA. 1995; 274:1591-8. Google Scholar Author, Article, and Disclosure InformationAuthors: Brendan M. Reilly, MDAffiliations: Cook County Hospital; Chicago, IL 60612 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byEnd-of-life care preferences of Canadian senior citizens with caregiving experience 15 February 1998Volume 128, Issue 4Page: 319KeywordsCardiopulmonary resuscitationDeath ratesInpatients ePublished: 15 August 2000 Issue Published: 15 February 1998 Copyright & PermissionsCopyright © 1998 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Growing up and moving on. A multicentre UK audit of the transfer of adolescents with juvenile idiopathic arthritis from paediatric to adult centred care
Authors: L P Robertson
Journal: Annals of the Rheumatic Diseases (2005)

<b>Objective:</b> To assess the provisions made for the transfer of adolescents with juvenile idiopathic arthritis to adult rheumatology clinics in the UK and the impact of a transitional care programme. <b>Methods:</b> An audit of the documentation of the provisions made for transfer in 10 centres participating in a controlled trial of transitional care. Each centre conducted a retrospective case note audit of the recent patients transferred to adult care before and 12–24 months after the start of the trial. Demographic details, age when transition was first discussed, age at transfer, transitional issues, multidisciplinary team involvement, adolescent self advocacy, and readiness were documented. <b>Results:</b> There were improvements at follow up in documentation of transitional issues, disease specific educational needs, adolescent readiness, and parental needs with the exception of dental care, dietary calcium, and home exercise programmes. The age at which the concept of an independent clinic visit was introduced was lower (mean (SD): 16.8 (1.06) <i>v</i> 15.8 (1.46) years, p = 0.01) but there were no other changes in age related transitional milestones. Significantly more participants had preparatory visits to the adult clinic, had a transition plan, and had joint injections while awake at follow up. <b>Conclusions:</b> The improvement in documentation suggests that involvement in the research project increased awareness of transitional issues. The difficulty of changing policy into practice was highlighted, with room for improvement, particularly at the paediatric/adult interface. The reasons for this are likely to be multiple, including resources and lack of specific training.
The Brazilian Peritoneal Dialysis Multicenter Study (BRAZPD): Characterization of the cohort
Authors: N. Fernandes, M.G. Bastos, H.V. Cassi, N.L. Machado, J.A. Ribeiro, G. Martins, O. Mourão, K. Bastos, S.R. Ferreira Filho, V.M. Lemos, M. Abdo, M.T.I. Vannuchi, A. Mocelin, S.L. Bettoni, R.V. Valenzuela, M.M. Lima, S.W. Pinto, M.C. Riella, A.R. Qureshi, J.C. Divino Filho, R. Pecoits-Filho
Journal: Kidney International (2008)
Outbreak of Nipah-virus infection among abattoir workers in Singapore
Authors: Nicholas I Paton, Yee Sin Leo, Sherif R Zaki, Alexander P Auchus, Kim En Lee, Ai Ee Ling, Suok Kai Chew, Brenda Ang, Pierre E Rollin, T Umapathi, Ivy Sng, Cheng Chuan Lee, Erle Lim, T.G Ksiazek
Journal: The Lancet (1999)
Hormone Therapy and Risk for Venous Thromboembolism: Comments and Correction
Authors: Deborah Grady, Eric Vittinghoff
Journal: Annals of Internal Medicine (2001)

Letters2 January 2001Hormone Therapy and Risk for Venous Thromboembolism: Comments and CorrectionDeborah Grady, MD, MPH and Eric Vittinghoff, PhDDeborah Grady, MD, MPHUniversity of California, San Francisco; San Francisco Veterans Affairs Medical Center (Grady, Vittinghoff)Search for more papers by this author and Eric Vittinghoff, PhDUniversity of California, San Francisco; San Francisco Veterans Affairs Medical Center (Grady, Vittinghoff)Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-134-1-200101020-00022 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail IN RESPONSE:We thank Drs. Peverill, Waitkevicz and Axelrod, and Goldstein for their comments on our manuscript.We found an error in the manuscript after publication. Rates of venous thromboembolic events in the first 90 days after lower-extremity fracture and myocardial infarction were mislabeled as numbers of events per 100 women. In fact, the cited values were rates per 100 woman-years. Since the at-risk period was only 90 days or 0.25 year, the number of events per 100 women in the first 90 days after lower-extremity fracture is 23 (the rate per 100 woman-years cited in our paper) × 0.25 = 5.8 ... Author, Article, and Disclosure InformationAffiliations: University of California, San Francisco; San Francisco Veterans Affairs Medical Center (Grady, Vittinghoff) PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoPostmenopausal Hormone Therapy Increases Risk for Venous Thromboembolic Disease: The Heart and Estrogen/progestin Replacement Study Deborah Grady , Nanette K. Wenger , David Herrington , Steven Khan , Curt Furberg , Donald Hunninghake , Eric Vittinghoff , Stephen Hulley , and Hormone Therapy and Risk for Venous Thromboembolism: Comments and Correction Roger Peverill Hormone Therapy and Risk for Venous Thromboembolism: Comments and Correction H. Joan Waitkevicz and Deborah Axelrod Hormone Therapy and Risk for Venous Thromboembolism: Comments and Correction Mark R. Goldstein Metrics 2 January 2001Volume 134, Issue 1Page: 81KeywordsEmotionsHormonal therapyHormonesMyocardial infarctionVenous thromboembolism ePublished: 2 January 2001 Issue Published: 2 January 2001 Copyright & PermissionsCopyright © 2001 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Red Blood Cell Transfusions
Authors: Max Harry Weil
Journal: JAMA (1970)

<h3>To the Editor.—</h3> It is difficult for me to lend allegiance to the conclusions presented by the AMA Committee on Transfusion and Transplantation in the editorial published inThe Journal(<b>212</b>:147, 1970). Specifically, transfusion of red blood cells (RBC) rather than whole blood would certainly provide additional safety in the case of a patient who has chronic anemia. The critical reduction in RBC mass is usually compensated for by an increase in plasma volume. Increases in cardiac output and in the speed of blood flow in the severely anemic patient increase the risk of "high output" heart failure. Transfusion of RBC would preclude additional volume loads and therefore minimize the risk of heart failure. The same considerations do not apply to the patient who has had acute blood loss. Under this circumstance, total blood volume is reduced and the more critical issue to survival is intravascular volume rather than
Endoscopic Duct Obstruction in Chronic Pancreatitis
Authors: W. Rösch, J. Phillip, Ch. Gebhardt
Journal: Endoscopy (1979)

Ligation of Wirsung's duct or obstruction with a glue may be an alternative to pancreatectomy in patients with intractable pain due to chronic relapsing pancreatitis. In 10 patients obstruction of Wirsung's duct was performed via endoscopic retrograde instillation of an alcoholic aminoacid solution into the ductal system. All patients became free of symptoms within one week; no complications were seen. Long-term follow-up data, however, suggest that clinical improvement may be persistent in only about 50 per cent of the patients. Further data are necessary before endoscopic obstruction of Wirsung's duct can be recommended as a conservative method in the treatment of chronic pancreatitis.
The White Wave
Authors: Thomas B. Cole
Journal: JAMA (2012)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Christmas Day in London: darling, I'm pregnant
Authors: G. Ruiz-Irastorza
Journal: BMJ (2000)

In August 1999 I moved with my wife from Bilbao in Spain to start a one year medical fellowship. We had been married for some years, but never tried to have children. Why not while in London? On Christmas Day we had a positive pregnancy test and many hopes about the future. Within the next five weeks our happy dreams had turned sour.

We booked the first visit with our local general practitioner in the seventh week of pregnancy. His only advice to my wife was to take folic acid, which she was already doing. Apart from that we had a brief chat about Spain. Never mind, we thought, we will soon be able to discuss our questions with the midwife or the obstetrician. We were wrong.

> We would like to point out what a fiasco we found our first experience as NHS patients 

What did the NHS offer my wife afterwards? Basically, unpleasant words. She was rejected from the hospital she was referred to, …
Physiologic Determinants of Ventilator Dependence in Long-term Mechanically Ventilated Patients
Authors: ANDREA PURRO, LORENZO APPENDINI, ANDREA DE GAETANO, MARTA GUDJONSDOTTIR, CLAUDIO F. DONNER, ANDREA ROSSI
Journal: American Journal of Respiratory and Critical Care Medicine (2000)

To investigate the pathophysiologic mechanisms of ventilator dependence, we took physiologic measurements in 28 patients with COPD and 11 postcardiac surgery (PCS) patients receiving long-term mechanical ventilation during a spontaneous breathing trial, and in 20 stable, spontaneously breathing patients matched for age and disease. After 40 ± 14 min of spontaneous breathing, 20 of 28 patients with COPD and all 11 PCS patients were judged ventilator-dependent (VD). We found that in the 31 VD patients tidal volume was low (Vt: 0.36 ± 0.12 and 0.31 ± 0.08 L for COPD and PCS, respectively), neuromuscular drive was high (P0.1: 5.6 ± 1.6 and 3.9 ± 1.9 cm H2O), inspiratory muscle strength was reduced (Pdimax: 42 ± 12 and 28 ± 15 cm H2O), and lung mechanics were abnormal, particularly PEEPi (5.9 ± 3.0 cm H2O) and lung resistance (22.2 ± 9.2 cm H2O/L/s) in COPD. The load/capacity balance was altered (Pdi/Pdimax and Ppl/Pplmax > 0.4) and the effective inspiratory impedance was high (P0.1/Vt/Ti ⩾ 10 cm H2O/L/s). Failure to wean occurred in patients with f/Vt > 105 breaths/min/L and 56% of patients with COPD with f/Vt < 80 breaths/min/L. Those who failed despite a low f/Vt ( < 80 breaths/min/L) either showed ineffective inspiratory efforts, which artificially lowered f/ Vt (n = 8), or did not increase breathing frequency (n = 5), but P0.1 and P0.1/Vt/Ti were as high as in other VD patients. In the 31 VD patients, PaCO2 increased during the weaning trial ( + 12.3 ± 8.0 mm Hg). We conclude that in the presence of a high drive to breathe, the imbalance between increased work load and reduced inspiratory muscle strength causes respiratory distress and CO2 retention. Noninvasive measurements (breathing pattern, P0.1, P0.1/ Vt/Ti) may give better insight into weaning failure useful in clinical decision-making, particularly in patients with COPD not showing rapid shallow breathing (56% in this study).
Acupuncture and the Practice of Medicine
Authors: William J. Curran
Journal: New England Journal of Medicine (1974)

A GREAT deal of attention is currently being given in the United States to the possible benefits of the ancient Chinese practice of acupuncture. It seems to be one of the most immediate results of the recent reopening of China to contact with the United States.The medicolegal problem that arises when a new or novel therapy is offered to the American public is whether it should be licensed or not, or whether it should receive some other form of legal scrutiny and authorization. About acupuncture, the most immediate question is whether the practice is "medical treatment" so that it is . . .
Unexpected Effect of Matrix Metalloproteinase Down-Regulation on Vascular Intravasation and Metastasis of Human Fibrosarcoma Cells Selected <i>In vivo</i> for High Rates of Dissemination
Authors: Elena I. Deryugina, Andries Zijlstra, Juneth J. Partridge, Tatyana A. Kupriyanova, Mark A. Madsen, Thales Papagiannakopoulos, James P. Quigley
Journal: Cancer Research (2005)

Abstract The human tumor/chick embryo model involving grafting of human HT-1080 fibrosarcoma cells on the chorioallantoic membrane was used in conjunction with quantitative real-time Alu PCR to select in vivo a pair of isogenic cell lines (HT-hi/diss and HT-lo/diss), dramatically differing in their ability to disseminate from the primary tumor (i.e., intravasate into the chorioallantoic membrane vasculature and metastasize to the lungs). During an immunohistochemical time course study, HT-hi/diss cells were sequentially visualized having escaped from the primary tumors, engaged with the blood vessels, and eventually observed inside the chorioallantoic membrane capillaries, thus reflecting early intravasating events. In contrast, HT-lo/diss cells seemed restricted to their primary tumor. Importantly, after i.v. inoculation, both variants arrested, extravasated, and proliferated in host tissues with similar efficiencies, highlighting that the observed earlier events at the periphery of the primary tumor could account for their differential dissemination. In a mechanistic probing of these events, we determined that HT-hi/diss intravasation was sensitive to a broad-range matrix metalloproteinase (MMP) inhibitor. To analyze the possible role of individual MMPs, membrane-bound MMP-14 and secreted MMP-9 were individually down-regulated in HT-hi/diss cells with their corresponding small interfering RNAs. Despite efficient down-regulation of MMP-14, neither intravasation nor metastasis of HT-hi/diss cells was affected significantly. However, a substantial down-regulation of MMP-9 was accompanied by a surprising 3-fold increase in intravasation and metastasis. The results emphasize a rising awareness that targeting certain MMPs might result in an enhanced malignancy, exemplified herein at the intravasation level as this step of the metastatic cascade is dissected and quantified.
Value of CT in Patients Undergoing Self-Expandable TAVR to Assess Outcomes of Concomitant Mitral Regurgitation
Authors: Ignacio J. Amat-Santos, Ana Revilla, Javier López, Carlos Cortés, Hipólito Gutiérrez, Ana Serrador, Federico Gimeno, Ana Puerto, Itziar Gómez, José A. San Román
Journal: JACC. Cardiovascular imaging (2014)
Effect of discotheque environment on epileptic children.
Authors: T P Berney, J W Osselton, I Kolvin, M J Day
Journal: BMJ (1981)

A free-field study of 22 epileptic children, selected on the basis of past electroencephalographic abnormality, identified a group who exhibited a significant increase in epileptiform discharge rate on electroencephalography in a discothèque environment (p less than 0.05). Laboratory investigations showed that these children were activated by a wide range of stimuli, including intermittent photic stimulation and exercise. The response to exercise was a good predictor of a child's electroencephalographic response in a discothèque. The findings suggest that most epileptic children are not particularly vulnerable in a discothèque environment.
Let's Stop Driving After Drinking and Using Other Psychoactive Drugs
Authors: George D. Lundberg
Journal: JAMA (1986)

"Ethyl alcohol (alcohol) kills every day in Chicago, Los Angeles, New York, Paris, and virtually every other city in the Western World."1 One of the principal ways in which it kills is by accidents, especially those involving motor vehicles. On Oct 12, 1984, we published an editorial about ethyl alcohol in which we set forth ten proposals. One was that "We as a society should make an abrupt change from our current practice of socially promoting so-called moderate drinking and driving as a norm and should, instead, by policy and example, simply not drive after drinking alcohol at all."<sup>1</sup> It is a source of great satisfaction to publish in this issue a report from the Council of Scientific Affairs<sup>2</sup>of the American Medical Association entitled "Alcohol and the Driver," which was adopted by the AMA at its Annual meeting in Chicago in June 1985, becoming official policy. This
1002-81 Age-related changes in adaptation of the heart to ischemia-reperfusion: A possible role for NADPH oxidase-induced superoxide production
Authors: Alexandra Oudot, Caroline Martin, David Busseuil, Pierre Sicard, Bertrand Collin, Catherine Vergely, Luc Demaison, Luc Rochette
Journal: Journal of the American College of Cardiology (2004)
Contraceptives and Cervical Carcinoma
Authors: B. Sandler
Journal: BMJ (1969)

between the smegma and the cervix may be exerting a beneficial effect in this respect.It would seem important, therefore, that the authors should again attempt to identify those women whose husbands are circumcised, and if this proves impossible in the present series it could perhaps be evaluated in the future.If indeed the incidence of uncircum- cised husbands remains the same in all ethnic groups examined and the statistical difference between diaphragm and steroid methods remains the same, it would seem that the diaphragm acting as a barrier against smegma might possibly be one of the explanations for this difference.-Iam, etc.,
Capillary filtration is reduced in lungs adapted to chronic heart failure: morphological and haemodynamic correlates
Authors: W Huang
Journal: Cardiovascular Research (2001)

Objective: To determine pulmonary capillary filtration in experimental chronic heart failure and to investigate some morphological and haemodynamic mechanisms that could account for reduced filtration in lungs adapted to chronic heart failure. Methods: We studied pulmonary capillary filtration, vascular resistances and morphology in lungs from guinea-pigs adapted to chronic heart failure. Heart failure was induced by banding of the ascending aorta (n = 66) or sham control operation (n = 78) in guinea-pigs which were studied at 150±8 days post-operation. Results: Reduced cardiac output, increased systemic vascular resistance and LV end diastolic pressure and increased LV and RV weight:body weight ratio (all P<0.05) indicated chronic heart failure at 5 months following aortic banding in guinea-pigs. Lung weight was increased (61%, P<0.05) in heart failure compared with controls, but lung water content was reduced (5.5%, P<0.05), a reversal of the pattern seen acutely. Studies in isolated perfused lungs demonstrated a reduced capillary filtration coefficient (0.018±0.003 vs. 0.003±0.002 ml min−1 mmHg−1 g−1, P<0.001), increased arterial (61%) and venous resistance (50%) in heart failure lungs, P<0.05. Wall thickness:lumen ratio was increased in small (<250 μm) pulmonary arterioles (0.15±0.02 vs. 0.08±0.01) and venules (0.06±0.005 vs. 0.04±0.002) in heart failure, P<0.01. Alveolar septal volume fractions (35.2±5.1 vs. 23.1±2.7) and septal:air-space volume ratios (60.5±13.6 vs. 31.9±5.3) were also increased in heart failure, P<0.05. Conclusions: Pulmonary adaptation to chronic heart failure is associated with vascular and alveolar remodelling that contributes to increased vascular resistance and reduced capillary filtration. These changes are likely to be important in mediating resistance to pulmonary oedema in chronic heart failure.