HEMOPHILIA AND ALLIED DISORDERS
Authors: PAUL W. CLOUGH
Journal: Annals of Internal Medicine (1954)

Editorial1 June 1954HEMOPHILIA AND ALLIED DISORDERSPAUL W. CLOUGHPAUL W. CLOUGHSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-40-6-1235 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptAlthough hemophilia is a relatively rare disease, its spectacular nature and its unusual clinical and genetic features have made it a subject of unusual interest both to the laity and to the medical profession. The disease has been recognized clinically for a century, and less definitive descriptions can be found in older writings back to the Talmud. Recent studies have amplified and modified some of our conceptions of the disease.Hemophilia is commonly defined as a disorder characterized by a tendency to abnormally persistent bleeding, eventually often exsanguinating, and by a prolonged coagulation time, which is usually hereditary, confined (almost)...1 Brinkhous KM: A study of the clotting defect in hemophilia, the delayed formation of thrombin, Am. J. M. Sc. 198: 509, 1935. CrossrefGoogle Scholar2 Quick AJ: Studies on enigma of hemostatic dysfunction of hemophilia, Am. J. M. Sc. 214: 272, 1947. CrossrefMedlineGoogle Scholar3 Pavlovsky A: Contribution to the pathogenesis of hemophilia, Blood 2: 185-191, 1947. CrossrefMedlineGoogle Scholar4 TocantinsCarrollHolburn DMRTRR: Clot accelerating effect of dilution on blood and plasma. Relation to the mechanism of coagulation of normal and hemophilic blood, Blood 6: 720, 1951. CrossrefMedlineGoogle Scholar5 Lewis JH: The relation of certain globulin fractions of the plasma globulins to the coagulation defect in hemophilia, Blood 1: 166, 1946. CrossrefMedlineGoogle Scholar6 LangdellWagnerBrinkhous RDRHKM: Effect of antihemophilic factor on one stage clotting tests, J. Lab. and Clin. Med. 41: 637, 1953. MedlineGoogle Scholar7 Merskey C: Hemophilia associated with normal coagulation time, Brit. M. J. 1: 906-912, 1951. CrossrefMedlineGoogle Scholar8 GrahamMcLendonBrinkhous JBWWKM: Mild hemophilia: an allelic form of the disease, Am. J. M. Sc. 225: 46-53, 1953. CrossrefMedlineGoogle Scholar9 Haberman S: Trans, of Fourth Conference On Blood Clotting and Allied Problems, New York, Josiah Macy, Jr. Foundation, 1951, Discussion, p. 101-112. Google Scholar10 Owren PA: The diagnosis of the hemophilic conductor, in Proc. Third Internat. Congress, Internat. Soc. Hematology, New York, Grune and Stratton, 1951, p. 446. Google Scholar11 Stefanini M: Hemophilia: Specific entity or syndrome? Blood 9: 273-280, 1954. CrossrefMedlineGoogle Scholar12 BrinkhousGrahamPenickLangdell KMJBGDRD: Studies on canine hemophilia, Trans. of Fourth Conference on Blood Clotting and Allied Problems, New York, Josiah Macy, Jr. Foundation, 1951, p. 51. Google Scholar13 Brinkhous KM: Newer approaches to the study of hemophilia and hemophilioid states, J. A. M. A. 154: 481-486, 1954. CrossrefMedlineGoogle Scholar14 Isreals MC: Hemophilia in the female, Lancet 1: 1375-1380, 1951. CrossrefMedlineGoogle Scholar15 Merskey C: The occurrence of hemophilia in the human female, Quart. J. Med. 20: 299-312, 1951. MedlineGoogle Scholar16 QuickHussey AJCV: Hemophilic condition in a girl, Am. J. Dis. Child. 85: 698, 1953. Google Scholar17 WhiteAggelerGlendenning SGPMMB: Plasma thromboplastin component (PTC). A hitherto unrecognized blood coagulation factor. Case report of PTC deficiency, Blood 8: 101-124, 1953. CrossrefMedlineGoogle Scholar18 Koller F: Ueber eine besondere Form haemorrhagischer Diathese, Schweiz. med. Wchnschr. 80: 41, 1950. Google Scholar19 Biggs R: Christmas disease. A condition previously mistaken for haemophilia, Brit. M. J. 2: 1378-1382, 1952. CrossrefMedlineGoogle Scholar20 RosenthalDreskinRosenthal RLOHN: New hemophilia-like disease caused by deficiency of a third thromboplastin factor, Proc. Soc. Exper. Biol. and Med. 82: 171, 1953. CrossrefMedlineGoogle Scholar21 AggelerWhiteSpaet PMSGTH: Deuterohemophilia: Plasma thromboplastic factor B deficiency. Plasma thromboplastin component (PTC) deficiency. Christmas disease, Hemophilia B, Blood 9: 246-253, 1954. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: PAUL W. CLOUGH PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byChristmas disease 1 June 1954Volume 40, Issue 6Page: 1235-1241KeywordsAllied health care professionalsClinical geneticsGenetic diseasesHemophiliaHemorrhage ePublished: 1 December 2008 Issue Published: 1 June 1954 PDF downloadLoading ...