tbuckley/cabot-search huggingface dataset:
Three-phase Bone Scintigraphy in Maffucciʼs Syndrome
Authors: ERKAN IBIS, GUNER ERBAY, GULSEREN ARAS, ALIT. ISITMAN, ARTHUR Z. KRASNOW, B. DAVID COLLIER
Journal: Clinical Nuclear Medicine (1992)

A 17-year-old boy had multiple painful, enlarging masses on both hands for several years. Physical examination of the hands demonstrated diffuse hypertrophy and deformity with multiple blue cutaneous masses; his left hand was more severely involved. A bone biopsy from the left hand revealed an enchondroma, and a biopsy from a cutaneous mass showed a cavernous hemangioma. The patient was diagnosed as having Maffucci's syndrome, a rare congenital, nonhereditary mesodermal dysplasia associated with multiple enchondromas and soft tissue hemangiomas.
Successful Treatment of Hepatic Hemangioma With Corticosteroids
Authors: Stanley J. Goldberg
Journal: JAMA (1969)

Corticosteroids were successfully employed to treat a patient with a large hepatic hemangioma which produced congestive cardiac failure. To our knowledge, this is the fifth reported case in which a patient with this condition survived and the first in which corticosteroids were employed. Corticosteroids should be considered as the major form of therapy for hepatic hemangiomas producing congestive heart failure because of the rapid effect on the hemangioma and the relative safety associated with their use.
Histopathology and Cytology in Detection
Authors: Joao C. Prolla
Journal: JAMA (1973)

Because of its tubular shape and relatively easy access, the esophagus is an organ in which endoscopic biopsy and diagnostic cytologic studies are both easy and accurate.<sup>43-45</sup>Unfortunately, by the time the majority of patients with carcinoma of the esophagus seek medical advice, they already have advanced tumor and their prognosis is very poor. Considering the relative ease of the available diagnostic procedures, and the very high detection rate of this combined diagnostic approach, it is obvious that the main problem is not accurate, but early, diagnosis. However, for the time being, endoscopic biopsy and diagnostic cytologic techniques remain tools of clinical practice rather than of mass screening; it is beyond the scope of this brief review to discuss the reasons involved. Hopefully, wider use of the diagnostic procedures will lead to better therapeutic results and will open the way for improved prognosis to be achieved ultimately by selected
Acute Pain Management Can Be Improved
Authors: J. Jarrett Clinton
Journal: JAMA (1992)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Chloroquine resistant Plasmodium falciparum malaria in Zimbabwe.
Authors: S L Mutambu, A B Dallas, C L Olweny
Journal: BMJ (1986)

Chloroquine resistant Plasmodium falciparum malaria in ZimbabweResistance of Plasmodium falciparum to chloroquine in Africa was first reported from Kenya in 1979.1 Since then reports of resistant strains from other parts of Africa have continued to appear.Drug sensitivity studies during the 1983 and 1984 malaria seasons in endemic areas in the north east and south east of Zimbabwe showed that P fakiparum infections in these localities were fully sensitive to a standard course ofchloroquine.2We report the first seven cases of confirmed chloroquine resistant P fakiparum infection acquired in the Zambezi Valley of Zimbabwe. Patients, methods, and resultsFour ofthe seven patients (cases 1-4) were treated for malaria between May and September 1984 as inpatients or outpatients in various Harare hospitals.They had been in the Zambezi Valley (either Kanyemba or Chirundu) on holiday or work transfer from Harare, an area hypoendemic for malaria, and were taking chloroquine as prophylaxis before the onset oftheir illness.All four patients failed to respond to at least the initial two standard courses of chloroquine and were referred for chloroquine sensitivity tests.The remaining three patients were resident in the Zambezi Valley, an area hyperendemic for malaria, and had asymptomatic Pfalciparum infections confirmed during routine drug sensitivity tests conducted in Kanyemba in August 1984.Blood samples from seven patients were subjected to the in vitro macro test for chloroquine resistant P fakiparum malaria.3Before in vitro testing, all the patients underwent the Dill-Glazko test for chloroquine in urine.4Schizont maturation was expressed in relation to 300 leucocytes.Blood smears from all seven patients before the in vitro tests disclosed parasitaemias ranging from 3020x 10' to 21 040x 10' parasites per litre of blood, and this was considered suitable for in vitro studies (table ).One patient (case 1) failed to respond to a single dose of 1500 mg sulfadoxine and 75 mg pyrimethamine (three tablets of Fansidar) and was finally cured with 4-5 g oral quinine and 5-25 g tetracycline administered concurrently over three and seven days, respectively.A single dose of Fansidar cured two patients (cases 2 and 3).Case 4 responded to a third course of chloroquine ([-8 g base parenterally) given five days after a course of sulphadimidine for a urinary tract infection.
Reviews and Notes: through the Patient's Eyes: Understanding and Promoting Patient-Centered Care
Authors: Rebecca J. Kurth
Journal: Annals of Internal Medicine (1994)

Literature of Medicine15 March 1994Reviews and Notes: through the Patient's Eyes: Understanding and Promoting Patient-Centered CareRebecca J. KurthRebecca J. KurthColumbia Presbyterian Medical Center, New York, NY 10032Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-120-6-199403150-00029 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail Through the Patient's Eyes: Understanding and Promoting Patient-Centered CareMargaret Gerteis, Susan Edgman-Levitan, Jennifer Daley, and Thomas L. Delbanco; eds. 300 pages. San Francisco: Jossey-Bass Publishers; 1993. $29.95.Patient dissatisfaction with the existing U.S. health care system has increased in recent years. The main outcries have been over issues of accessibility, affordability, and quality. Because the public is demanding a more active role in its medical care, health care professionals must understand what patients want and need. Through the Patient's Eyes addresses the issue of quality. Its premise is that understanding the patient's perspective and creating a more “patient-centered” hospital ... Author, Article, and Disclosure InformationAffiliations: Columbia Presbyterian Medical Center, New York, NY 10032 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 15 March 1994Volume 120, Issue 6Page: 527KeywordsEmotionsHealth careHealth care qualityHealth information technologyHospital medicineHospitalizationsPatientsQuestionnaires Issue Published: 15 March 1994 Copyright & PermissionsCopyright © 1994 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
High-Dose Salvage Intensity-Modulated Radiotherapy With or Without Androgen Deprivation After Radical Prostatectomy for Rising or Persisting Prostate-Specific Antigen: 5-Year Results
Authors: Piet Ost, Nicolaas Lumen, An-Sofie Goessaert, Valérie Fonteyne, Bart De Troyer, Filip Jacobs, Gert De Meerleer
Journal: European Urology (2011)
A Major Mitochondrial Gene Rearrangement Among Closely Related Species
Authors: Timothy A. Rawlings, Timothy M. Collins, Rüdiger Bieler
Journal: Molecular Biology and Evolution (2001)

The sequential order of genes in animal mitochondrial DNA tends to be conserved at high taxonomic levels. Consequently, when mitochondrial gene rearrangements occur, they can provide compelling markers of ancient phylogenetic history (see reviews in Boore, Daehler, and Brown [1999], Saccone et al. [1999], and references therein). Such gene order characters have proven particularly useful for resolving deep-branching events characterizing superphyla, phyla, and classes, a scale over which nucleotide sequence analysis has often proven problematic (e.g., Smith et al. 1993; Boore and Brown 1994a, 1998, 2000; Boore et al. 1995; Boore, Lavrov, and Brown 1998; Stechmann and Schlegel 1999). Most frequently, these rearrangements are associated with the movement of tRNA genes which, based on their stem-and-loop structure, may also have an underlying role as mobilizing elements within the mitochondrial genome (Moritz and Brown 1987; Stanton et al. 1994; Saccone et al. 1999). Gene rearrangements involving ribosomal and protein-encoding genes (hereinafter referred to as ‘‘major’’ genes), however, are much rarer. Here we report a mitochondrial gene rearrangement involving major genes that has occurred within a genus of marine vermetid gastropods that diversified within the Cenozoic. Based on data from the fossil record and an independent molecular calibration, we estimate that this gene order change may have occurred within the last 38–48 Myr, making this a very recent major gene order rearrangement. This finding thus has important implications for the use of gene order characters in metazoan phylogeny, in terms of both understanding the mechanism of gene order rearrangements and determining the taxonomic level and timescale over which these major rearrangements may prove useful. The family Vermetidae comprises seven genera with ;100 extant species of sessile, uncoiled, suspension-feeding gastropods found in shallow marine waters in warm temperate to tropical latitudes throughout the world (Keen 1961; Morton 1965; unpublished data). Based on our current understanding of gastropod evolution, vermetid gastropods radiated from a basal caenogastropod stock sometime in the early Cenozoic (Keen 1961; unpublished data). As part of a study to investi-
THE RETICULO-ENDOTHELIAL SYSTEM AND HORMONE REFRACTORINESS
Authors: Albert S. Gordon, William Kleinberg, Harry A. Charipper
Journal: The Journal of Experimental Medicine (1939)

1. Young splenectomized female rats, free of latent infection, show greater increases in ovarian weight in response to injections of pregnant mare's serum than do young normal rats with spleens intact. 2. The regression in ovarian weight which occurs after about a month in such injected splenectomized animals may be prevented by repeated injections of an agent like trypan blue which causes blockage of the compensating reticulo-endothelial elements. 3. The plasmas obtained from these splenectomized and splenectomized dye-blocked animals possess less antihormone substance than plasmas from similarly treated normal animals. 4. Young female rats, heavily infected with Bartonella muris, and therefore possessing an injured reticulo-endothelial system, develop heavier ovaries in response to injections of pregnant mare's serum than do normal uninfected rats. 5. Similar differences in effect on the testes and seminal vesicles of young normal, splenectomized, and bartonella-infected male rats have been obtained using pregnancy urine extract. 6. Young splenectomized, and splenectomized dye-blocked guinea pigs injected with thyrotropic extract, show heavier and more highly active thyroids than normal hormone-injected animals, 7. These results are explained on the basis that the reticulo-endothelial system participates in the production of antihormone substances.
The Occurrence of Chlamydial and Gonococcal Salpingitis During the Menstrual Cycle
Authors: Richard L. Sweet, Michael Blankfort-Doyle, Marilyn O. Robbie, Julius Schacter
Journal: JAMA (1986)

We evaluated 104 women hospitalized with a diagnosis of acute salpingitis to compare the relationship between the menstrual cycle and onset of acute chlamydial and/or gonococcal salpingitis and acute salpingitis associated with other facultative aerobic and anaerobic bacteria. Neisseria gonorrhoeae was recovered from 42 women (40%), Chlamydia trachomatis from 28 (27%), and nongonococcal, nonchlamydial organisms only from the upper genital tract in 48 (46%). Among 37 cases with symptoms of acute salpingitis within seven days of onset of menses, 30 (81%) had chlamydial and/or gonococcal infection. Of 35 cases with onset after 14 days postmenses, 23 (66%) had nongonococcal, nonchlamydial organisms only. Of the 28 women with chlamydial infection, 17 (57%) had the onset of disease within one week from the first day of their last menstrual period. Similarly, 23 (55%) of gonococcal infections had onset of symptoms within one week from onset of menses. However, only seven (14%) of the women with nongonococcal, nonchlamydial salpingitis reported onset of symptoms within one week. The temporal pattern of onset of chlamydial or gonococcal acute salpingitis showed significant differences when compared with the time of onset for nongonococcal, nonchlamydial acute salpingitis.
Evaluating Open Access: Problems with the Program or the Studies?
Authors: Mark F. Murray
Journal: Annals of Internal Medicine (2008)

Letters16 December 2008Evaluating Open Access: Problems with the Program or the Studies?Mark F. Murray, MD, MPAMark F. Murray, MD, MPAFrom Mark Murray & Associates, Sacramento, CA 95816.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-149-12-200812160-00013 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:I had the opportunity to read the article by Mehrotra and colleagues (1). As one of the authors commonly cited in the article's references section, I feel qualified to comment. Although I applaud the efforts of the practices to make fundamental changes in the way they operate, to make a systematic approach to improvements, and to explore change over time, this investigation contains serious and fundamental flaws. First, my co-authors and I have emphasized that the fundamental dynamic in appointment scheduling is the necessity of balancing or matching patient demand with practice appointment supply or capacity. The ...References1. Mehrotra A, Keehl-Markowitz L, and Ayanian JZ. Implementing open-access scheduling of visits in primary care practices: a cautionary tale. Ann Intern Med. 2008;148:915-22 LinkGoogle Scholar2. Murray M, Davies M, and Boushon B. Panel size: how many patients can one doctor manage? Fam Pract Manag. 2007;14:44-51. [PMID: 17458336] MedlineGoogle Scholar3. Murray M, Davies M, and Boushon B. Panel size: answers to physicians' frequently asked questions. Fam Pract Manag. 2007;14:29-32. [PMID: 18046954] MedlineGoogle Scholar4. Murray M. Answers to your questions about same-day scheduling. Fam Pract Manag. 2005;12:59-64. [PMID: 15813306] MedlineGoogle Scholar5. Committee on Quality of Health Care in America. Institute of Medicine. Crossing the Quality Chasm: A New Health System for the 21st Century. Washington, DC National Academy Pr 2001. Google Scholar Author, Article, and Disclosure InformationAuthors: Mark F. Murray, MD, MPAAffiliations: From Mark Murray & Associates, Sacramento, CA 95816.Disclosures: Mark Murray & Associates Healthcare consulting group. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoImplementing Open-Access Scheduling of Visits in Primary Care Practices: A Cautionary Tale Ateev Mehrotra , Lori Keehl-Markowitz , and John Z. Ayanian Evaluating Open Access: Problems with the Program or the Studies? Daren R. Anderson Evaluating Open Access: Problems with the Program or the Studies? Chris Salisbury Evaluating Open Access: Problems with the Program or the Studies? Arthur L. Kellermann Evaluating Open Access: Problems with the Program or the Studies? Ateev Mehrotra , Lori Keehl-Markowitz , and John Z. Ayanian Metrics 16 December 2008Volume 149, Issue 12Page: 909 ePublished: 16 December 2008 Issue Published: 16 December 2008 Copyright & PermissionsCopyright © 2008 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
The A, B and H Blood-Group Antigens in Human Placenta
Authors: Aron E. Szulman
Journal: New England Journal of Medicine (1972)

Thirty human placentas of embryo fetuses of various ABO blood groups and representing all stages of pregnancy between the fifth week (ovulation age) and term were examined for the ABH antigens by immunofluorescence. The trophoblast was consistently negative for both the H and A, B antigens, and the endothelium of the vessels of the chorion, villi and umbilical cord possessed only the basic H structure. The findings contrast with full antigenic complement of the endothelium and of sundry epithelia in the embryo fetus proper, each according to its ABO blood group. The lack of demonstrable ABH antigens in the trophoblast tallies with a similar lack of demonstrable transplantation antigens; it renders the trophoblast unassailable by maternal A, B isoagglutinins.
Biocompatibility of amphiphilic diblock copolypeptide hydrogels in the central nervous system
Authors: Chu-Ya Yang, Bingbing Song, Yan Ao, Andrew P. Nowak, Ryan B. Abelowitz, Rose A. Korsak, Leif A. Havton, Timothy J. Deming, Michael V. Sofroniew
Journal: Biomaterials (2009)
Colony growth of human hematopoietic progenitor cells in the absence of serum is supported by a proteinase inhibitor identified as antileukoproteinase.
Authors: H M Goselink, J van Damme, P S Hiemstra, A Wuyts, J Stolk, W E Fibbe, R Willemze, J H Falkenburg
Journal: The Journal of Experimental Medicine (1996)

Serum contains many growth factors and nutrients that stimulate colony formation of hematopoietic progenitor cells (HPC) in semisolid cultures. In the absence of serum, no proliferation of HPCs could be obtained in semisolid medium cultures of partially purified bone marrow cells in the presence of multiple hematopoietic growth factors, insulin, cholesterol, and purified clinical-grade human albumin. This appeared to be due to a suppressive activity induced by monocyte- and T lymphocyte-depleted accessory cells on CD34+ HPCs. Serum-free conditioned medium from the bladder carcinoma cellline 5637 could replace serum to support the growth of HPCs in these cultures. After gel filtration and reverse-phase high-performance liquid chromatography of 5637 supernatants, this activity could be attributed to a 15-kD protein that was further identified by NH2-terminal sequence analysis as the serine proteinase inhibitor antileukoproteinase (ALP). The growth-supportive activity from the 5637 conditioned medium and the (partially) purified fractions could be completely neutralized by a polyclonal rabbit IgG antibody against human ALP (huALP). Similar supportive effects on the growth of HPC could be obtained in the presence of recombinant huALP. We demonstrated that the COOH-terminal domain of ALP containing the proteinase inhibitory activity was responsible for this effect. alpha-1 proteinase inhibitor was capable of similar support of in vitro HPC growth. These results illustrate that proteinase inhibitors play an important role in the in vitro growth of hematopoietic cells by the neutralization of proteinases produced by bone marrow accessory cells. This may be of particular relevance for in vitro expansion of human hematopoietic stem cells in serum-free media.
Clinical Pharmacology of Psychotherapeutic Drugs
Authors: James H. Kocsis
Journal: JAMA (1984)

Dr Hollister's revised monograph is a good, brief, up-to-date summary of the major areas of importance in clinical psychopharmacology. Sections are devoted to sedative-hypnotic drugs, antidepressants, antipsychotics, and antimaniacal agents. Discussions of posited pathophysiological mechanisms of major psychiatric disorders and basic pharmacologic considerations of major drug groups are nicely integrated with descriptions of clinical use in each section of the book. Clinicians will benefit from segments devoted to discussion of recently approved antidepressant and benzodiazepine drugs not present in psychopharmacology texts published before this decade. Furthermore, the author has a wealth of clinical and research experience in the area of psychopharmacology, which is manifest throughout the text in a peppering of clinical vignettes and methodological observations. It is probably inevitable that any book covering a field as controversial and uncertain as clinical psychopharmacology would contain assertions and suggestions of debatable validity. Clearly this tends to occur more in areas where
Telematic Transmission of Computerized Blood Glucose Profiles for IDDM Patients
Authors: Alain Billiard, Vincent Rohmer, Marie-Agnès Roques, Marie-Geneviève Joseph, Sylvestro Suraniti, Philippe Giraud, Jean-Marie Limal, Philippe Fressinaud, Michel Marre
Journal: Diabetes Care (1991)

Objective To improve the analysis of self-monitoring of blood glucose (SMBG) and its communication between patients and physicians by a telematic transmission of computerized SMBG and to study the consequences of its use on glucose control of insulin-dependent diabetic (IDDM) patients. Research Design and Methods A prospective randomized crossover trial with two 3-mo periods, one with SMBG recorded on traditional booklets (booklet period) and another with computerized SMBG transmitted to a central data base through a telematic network (telematic period), comprised the study. During the latter phase, patients could receive computerized SMBG analysis on individual terminals connected to the telephone network (Minitel system). Blood glucose recordings and HbA1c were measured at inclusion and end of each period. Eleven pairs of IDDM patients on intensified insulin therapy were randomized within each pair to start with the telematic period (group A) or the booklet period (group B). Results Telematic transmissions were successful (&amp;lt;1% failure rate). Although initial HbA1c was low (6.7%), it declined during the telematic period (Δ = -0.41%) compared with the booklet period (Δ = + 0.37%, P = 0.05). The percentage of low (&amp;lt;3.3 mM) blood glucose values correlated with HbA1c changes during the telematic period (r = 0.714, P= 0.0014) but not the booklet period. The patients favored the telematic tool to analyze SMBG. Conclusions Telematic transmission of SMBG is feasible. It can improve SMBG analysis and perhaps glucose control, therefore offering a new way of communication between diabetic patients and their physicians.