Ranitidine and Theophylline
Authors: Marie E. Gardner, Gerlad W. Sikorski
Journal: Annals of Internal Medicine (1985)

Letters and Corrections1 April 1985Ranitidine and TheophyllineMARIE E. GARDNER, Pharm.D., GERLAD W. SIKORSKI, D.O.MARIE E. GARDNER, Pharm.D.Search for more papers by this author, GERLAD W. SIKORSKI, D.O.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-102-4-559_1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: A recent report described theophylline toxicity during ranitidine administration (1). We wish to report a similar experience.A 74-year-old white woman was hospitalized with substernal chest pain, nausea, dyspnea, and diaphoresis. Before hospitalization the patient had received theophylline (Theo-Dur; Key Pharmaceuticals, Inc., Miami, Florida), 300 mg twice a day; furosemide, 40 mg/d; digoxin (Lanoxin; Burroughs-Wellcome Co., Research Triangle Park, North Carolina), 0.25 mg/d; and potassium. The theophylline level on admission was 16.6 µg/mL. Treatment was continued with these drugs and 2 days later, ranitidine hydrochloride (Zantac; Glaxo Inc., Fort Lauderdale, Florida), 150 mg twice daily, was added...References1. FERNANDESMELEWICZ EF. Ranitidine and theophylline [Letter]. Ann Intern Med. 1984; 100:459. LinkGoogle Scholar2. JACKSONPOWELLWANDELLBENTLEYDORR JJMJR. Cimetidine decreases theophylline clearance. Am Rev Respir Dis. 1981;123:615-7. MedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byEffects of omeprazole and cisapride treatment in Japanese asthmatics with reflux esophagitisTreatment of theophylline overdoseEffect of Ranitidine on Theophylline Metabolism in Healthy Koreans Living in ChinaPhenytoin Concentration Elevation Subsequent to Ranitidine AdministrationTheophylline toxicityComparative Investigation of the Influence of Nizatidine, Ranitidine, and Cimetidine on the Steady-State Pharmacokinetics of Theophylline in COPD PatientsRanitidine treatment and cortisol metabolism in manDrug-Drug Interactions with H2-Receptor AntagonistsThe drug interaction potential of ranitidine: An updateRanitidine—Theophylline Interaction—Fact or Fiction?Histamine 2 -Receptor AntagonistsEffect of cimetidine and ranitidine on plasma theophylline in patients with chronic obstructive airways disease treated with theophylline and corticosteroidsInterspecies Metabolism and Pharmacokinetic Scaling of Theophylline DispositionComparison of the Parenteral Histamine 2 -Receptor AntagonistsEffects of equimolar doses of cimetidine and ranitidine on theophylline eliminationTheophylline toxicity subsequent to ranitidine administration: A possible drug-drug interactionInduction of theophylline toxicity and inhibition of clearance rates by ranitidineComment: Peptic Ulcer H2-receptor Antagonist TherapyMethylxanthines: Toxicity to humans. 1. TheophyllineSafety perspectives on parenteral H2-receptor antagonistsCimetidine and ranitidine on basal and ACTH-stimulated steroidogenesis.Clinically Important Adverse Effects and Drug Interactions with H 2 -Receptor Antagonists: An UpdateUpdate on methylxanthine therapyRanitidine drug interactions—a literature reviewGastrointestinal drugsAdverse Reactions and Interactions with H2-Receptor Antagonists 1 April 1985Volume 102, Issue 4Page: 559-559KeywordsDrugsDyspneaHospitalizationsIschemiaNauseaPotassiumTheophylline toxicity Issue Published: 1 April 1985 PDF downloadLoading ...