tbuckley/cabot-search huggingface dataset:
Abstract 645: IGM-55.5, a novel monoclonal human recombinant IgM antibody with potent activity against B cell leukemia and lymphoma
Authors: Omar Duramad, Beatrice Wang, Fen Zheng, Lena Keyt, Claire Repellin, Lucia Beviglia, Neelima Bhat, Marcia Bieber, Nelson Teng, Bruce Keyt
Journal: Cancer Research (2014)

Abstract IGM-55.5 is an engineered monoclonal human recombinant IgM antibody that was derived from a natural monoclonal antibody 216 isolated at Stanford University from the splenocytes of a patient with Non-Hodgkin's lymphoma. HuMab 216 was previously used in a B-cell acute lymphoblastic leukemia phase I trial and was demonstrated to be well tolerated with significant decrease in peripheral blasts observed (Liedtke et al, Haematologica, 2012). IGM-55.5 has been engineered to be mono-reactive and recognizes a carbohydrate determinant as an epitope on normal human B cells as well as B-cell lymphoma and B-progenitor lymphoblasts. Here, we report new preclinical studies that describe the mechanism of action and potent activity of IGM-55.5. In-vitro analysis of IGM-55.5 was found to have high surface binding on a broad panel of B cell leukemia and lymphoma cells lines by flow cytometry. IGM-55.5 binding leads to the disruption of the plasma membrane and formation of large membrane pores resulting in cell lysis. This non-classical apoptosis occurs in the absence of complement fixation but in vitro cytotoxicity is increased in assays in the presence of human complement. Studies with aggressive disseminated tumor xenograft models (Namalwa, Granta, &amp; Nalm-6) demonstrate that IGM-55.5 significantly prolongs survival and reduces circulating tumor cells. Peripheral blood samples from chronic lymphocytic leukemia patients demonstrated the potent activity of IGM-55 in eliminating B cell lymphoblasts in comparison with Rituxan when treated in-vitro. These data taken together highlight the potent activity of IGM-55.5 as therapeutic for advanced B cell malignancies, especially indicated for Rituxan resistant or refractory patients. Citation Format: Omar Duramad, Beatrice Wang, Fen Zheng, Lena Keyt, Claire Repellin, Lucia Beviglia, Neelima Bhat, Marcia Bieber, Nelson Teng, Bruce Keyt. IGM-55.5, a novel monoclonal human recombinant IgM antibody with potent activity against B cell leukemia and lymphoma. [abstract]. In: Proceedings of the 105th Annual Meeting of the American Association for Cancer Research; 2014 Apr 5-9; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2014;74(19 Suppl):Abstract nr 645. doi:10.1158/1538-7445.AM2014-645
Alimentary Tract Roentgenology.
Authors: Alexander R. Margulis, H. Joachim Burhenne
Journal: Annals of Internal Medicine (1974)

In the six years since Margulis and Burhenne's Alimentary Tract Roentgenology was first printed, it has established itself as a basic reference for all practicing radiologists, radiology residents and other physicians involved in the diseases of the gastrointestinal tract. During this interval new techniques and new concepts have been developed, new insights into the pathophysiology of gastrointestinal disease have been formed, and the role of the radiologist in the diagnosis and overall management of gastrointestinal disease has substantially expanded. These changes are reflected in the second edition of Alimentary Tract Roentgenology which became available in the fall of 1973. The new text is approximately 500 pages longer, the number of illustrations is more than double while avoiding duplication of content, and the index has been expanded from 15 to 42 pages, greatly enhancing the usefulness of the text as a rapid reference source. Two new chapters on physiology provide clear, concise, and up-to-date information on the normal mechanisms involved in digestion and absorption. Emphasis on the radiographic correlation with pathophysiology is initiated here and continued throughout much of the new material. Sections dealing with pathology have now been integrated into each separate anatomical division, thereby increasing its exposure and utilization, while serving to emphasize the close relationship that must exist between the two diagnostic methods. New chapters dealing with abdominal trauma and motility disorders of the esophagus fill a void which had detracted from the overall value of the first edition. The chapter on colonic polyps has been brought up-to-date with a concise discussion of the polyposis syndromes. A major addition to the section on the liver and biliary tract is Arthur Clemett's new chapter, in which he uniquely combines cholangiography, arteriography and portography, isotope scanning, barium contrast and plain film studies to clearly portray a host of congenital, inflammatory, vascular, and neoplastic abnormalities of the liver and biliary tree. Burhenne's chapter on the biliary tract includes a discussion on the removal of retained common duct stones, a technique of immense clinical value. Its recognition and inclusion in this text will assist greatly in the widespread application of this exciting technique. The increased use of arteriography in the abdomen is reflected in the expanded chapter devoted to this topic. The illustrations are excellent and the bibliography is current. In summary, this new edition of Alimentary Tract Roentgenology has substantially increased in value over the original text as an inclusive reference work on the radiology of gastrointestinal disease. It belongs in every radiologist's library.
Allogeneic bone marrow transplantation from HBsAg+ donors: a multicenter study from the Gruppo Italiano Trapianto di Midollo Osseo (GITMO)
Authors: A Locasciulli, A Alberti, G Bandini, P Polchi, W Arcese, P Alessandrino, A Bosi, M Testa, A Bacigalupo
Journal: Blood (1995)
Pulse Oximeter as a Cause of Skin Burn During Photodynamic Therapy
Authors: None Radu, None Zellweger, None Grosjean, None Monnier
Journal: Endoscopy (1999)

Photodynamic therapy is increasingly being used for the treatment of various cancers. However, this technique has a major adverse effect, namely skin photosensitization. An unusual case of skin burn associated with pulse oximetry during photodynamic therapy in a patient treated for an early esophageal tumor is described. The patient, who was treated with mTHPC, suffered a second-degree burn on the index finger with subsequent loss of the nail. The only previously reported case of such a complication occurred with Photofrin, whereby no tissue other than skin was damaged.
Unilateral Stellate Purpura of the Ankle
Authors: Jennifer C. Aronica, Arash Radfar, Ali A. Damavandy
Journal: JAMA Dermatology (2015)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Dermatology HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Dermatology journal
B-lymphocyte targeted therapy for patients with progressive fibrosing mediastinitis
Authors: Blair Westerly, Geoffrey Johnson, Fabien Maldonado, James Utz, Ulrich Specks, Tobias Peikert
Journal: European Respiratory Journal (2014)

Background: Fibrosing Mediastinitis (FM) is an idiosyncratic fibro-inflammatory syndrome characterized by the progressive proliferation of fibrous tissue in the mediastinum. In North America it is most commonly associated with Histoplasma infection. Clinical disease manifestations of FM are directly related to the compression and compromise of vital mediastinal structures. Patients with progressive bilateral FM face high morbidity and mortality. There are currently no effective medical treatment options. We previously demonstrated prominent B-lymphocyte infiltration in FM.

Hypothesis:B-lymphocytes may promote the fibro-inflammatory response in FM and their depletion using rituximab may represent a novel therapeutic alternative.

Methods: Prospective off label therapy of 3 patients with progressive and/or bilateral metabolically active (FDG-PET/CT positive) FM with rituximab. Patient 1 received 375 mg/m2 of rituximab for 4 weekly doses, and patients 2 and 3 were treated with 1000 mg of rituximab twice 15 days apart. All patients received a 2 months taper of Prednisone and Bactrim for pneumocystis pneumonia prophylaxis. Clinical, radiological and metabolic responses were recorded.

Results: Circulating B-lymphocytes were depleted. There were no severe side effects. All patients had favorable therapeutic responses. The lesion resolved in patient 1 and steroids were tapered successfully. Patients 2 and 3 experienced a dramatic symptomatic improvement and resolution of pleural effusion (Patient 2). Patients 2 and 3 had significant metabolic responses by FDG-PET/CT and lesions size decreased in Patient 3 by CT.

Conclusion:B-lymphocyte depletion with rituximab may be the first effective therapy for FM.
Preventive and therapeutic effects of phosphoinositide 3-kinase inhibitors on acute lung injury
Authors: Xiaocong Fang, Chengshui Chen, Yaoli Wang, Xuwen Chen, Chunxue Bai, Xiangdong Wang
Journal: European Respiratory Journal (2011)

Background: Phosphoinositide 3-kinases (PI3Ks) are involved in a number of biological responses. Recent preclinical studies demonstrated that PI3K-dominent signal pathway could play an important and critical role in the development of acute lung injury, while the number of studies are limited and the mechanism remains unclear.  Methods: CD-1 mice were intranasally or intragastrically administered with different PI3K inhibitors once a day for three days before intratracheal instillation of LPS for 4 and 24 hours. Effects of SHBM1009 on LPS-induced capillary permeability, leukocyte distribution and epithelial cells were measured. Besides, the therapeutic effects of SHBM1009 on pancreatic elastase induced lung injury was evaluated in wistar rats.  Results: Local delivery of PI3K inhibitors had more effective roles in the prevention from LPS-induced ALI than systemic delivery. PI3K inhibitors prevented both LPS- or elastase-induced lung injury in mice and rats probably through the directly inhibitory effects on airway epithelial cells, activating neutrophils and macrophages.  Conclusion: PI3K may be a therapeutic target for lung injury.
Abstract 11012: Safety of Beta-Blocker Use in Cocaine-Associated Chest Pain: A Meta-Analysis of 1,794 Patients
Authors: Don Pham, Waleed Kayani, Daniel Addison, Arunima Misra, Hani Jneid, Nasser Lakkis, Mahboob Alam
Journal: Circulation (2014)

Background: Beta-Blockers (BB) have been an established therapy in acute coronary syndrome. Due to the risk of unopposed α-adrenergic stimulation and coronary vasospasm in patients with cocaine-associated chest pain (CACP), their use in this population remains controversial. Few studies exist addressing the role of BB in CACP.

Methods: A comprehensive literature search using PubMed (MEDLINE) and EMBASE was performed using keywords “beta blocker” and “cocaine.” The publications were filtered for either retrospective or prospective studies that included CACP patients with or without BB. Outcomes of interest included non-fatal myocardial infarction (MI) and all-cause mortality. Of 580 identified abstracts, 5 studies met the inclusion criteria (1,794 patients). Data on baseline characteristics and outcomes of interest were extracted. Meta-analysis was performed using Review Manager Version 5.0 (Cochrane Collaboration). Effect sizes for outcomes of interest were estimated using odds ratio (OR) and 95% confidence intervals (CI). Given the inherent heterogeneity in the data, results from the random effects model were reported.

Results: Five trials (n=1,756) reported on MI in CACP with no significant difference between patients on BB vs. no BB (OR 1.36, 95% CI 0.68-2.75, p = 0.39, I2 = 71%). Three trials (n=1,014) reported on all-cause mortality with no significant difference in all-cause mortality in patients on BB vs. no BB (OR 0.17, 95% CI 0.01-4.74, p = 0.30, I2=86%).

Conclusion: This is the first meta-analysis to examine the impact of BB in patients with CACP. Our results indicate that BB use was not associated with an increased risk of MI or all-cause mortality. These findings are of clinical significance given lower use of BB (a guideline-driven therapy) in CACP, and underlines the paucity of data plus need for additional clinical studies in this area.

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Restoration of photoreceptor ultrastructure and function in retinal degeneration slow mice by gene therapy
Authors: Robin R. Ali, Gian-Marco Sarra, Clare Stephens, Mahesh de Alwis, James W.B. Bainbridge, Peter M. Munro, Sascha Fauser, Martin B. Reichel, Christine Kinnon, David M. Hunt, Shomi S. Bhattacharya, Adrian J. Thrasher
Journal: Nature Genetics (2000)
Abstract P301: Age Differences in the Association between Waist-to-height Ratio and Risk of Cardiovascular Disease: The Suita Study
Authors: Yukako Tatsumi, Makoto Watanabe, Yoshihiro Kokubo, Kunihiro Nishimura, Tomonori Okamura, Akira Okayama, Yoshihiro Miyamoto
Journal: Circulation (2013)

Introduction: Waist-to-heightratio (WHtR) has been shown to be useful global screening tool forcardiovascular disease (CVD) in the recent meta-analysis. The impact of WHtR on the risks of CVD by age is not well known. Hypothesis: We assessed whether the association between WHtR and the risks of CVD was different by age categories. Methods: This study is a population-based cohort study in an urban area of Japan. Study participants comprised 5,488 Japanese urban residents (2,600 men and 2,888 women) aged 30-83 years with no history of CVD. At baseline (1989&amp;#8211;1994), waist circumference was measured at the umbilical level and height with bare feet was measured. WHtR was calculated as waist circumference (cm) divided by height (cm). The criteria of myocardial infarction were based on the WHO Monitoring of Trends and Determinants in Cardiovascular Disease Projects. In addition to myocardial infarction, we also evaluated coronary angioplasty, coronary artery bypass grafting and sudden cardiac death, all of which were defined as coronary heart disease (CHD). A stroke was defined according to criteria from the US National Survey of Stroke and confirmed by computed tomography. We stratified participants by sex and age groups (30&amp;#8211;49, 50&amp;#8211;69 and 70&amp;#8211;83 years). The Cox proportional hazard ratios (HRs) and 95% confidence intervals (95% CIs) for CVD according to the quartiles of WHtR were calculated after adjustment for age, smoking and drinking status. Results: During the follow-up period (13.0 years in average), 428 CVD events (184 CHD and 244 strokes) were observed. Men with the highest quartile of WHtR aged 50&amp;#8211;69 years had significantly increased the risks of CVD and CHD, compared with the lowest quartile; the HRs (95% CIs) were 1.81 (1.13&amp;#8211;2.90) and 2.47 (1.17&amp;#8211;5.20), respectively. There were statistically significant linear increases in the HRs of CVD ( p for trend =0.01), CHD ( p for trend =0.02) and cerebral infarction ( p for trend =0.03) in this group. Women with the highest quartile of WHtR aged 50&amp;#8211;69 years had significantly increased the risks of stroke; the HRs (95% CIs) was 2.43 (1.01&amp;#8211;5.84). There were statistically significant linear increases in the HRs of CVD ( p for trend =0.04) and stroke ( p for trend =0.04) in this group. However, the similar results were not observed in the other age groups in both sexes. We observed a significant interaction between age groups and WHtR categories for the risks of CVD in men ( p for interaction=0.02). Conclusions: The association between WHtR and CVD was different among age groups. WHtR could be useful to predict the risks of CVD in middle aged men and women.
Abstract MP69: Relationships Between Sleep Apnea, Cardiovascular Disease Risk Factors, and Aortic Pulse Wave Velocity over 9 Years: The Wisconsin Sleep Cohort
Authors: Rebecca Stern, Claudia E Korcarz, Paul E Peppard, Jodi H Barnet, Erika W Hagen, Terry Young, James H Stein
Journal: Circulation (2015)

Background: Cardiovascular disease (CVD) risk factors associated with obstructive sleep apnea (OSA) contribute to endothelial dysfunction and arterial stiffening. We hypothesized that OSA severity would predict aortic pulse wave velocity (PWV) after nearly a decade of aging in the Wisconsin Sleep Cohort (WSC). Methods: Subjects were 596 participants in the WSC that underwent overnight polysomnography between 2000 and 2008; subsequent tonometry data was acquired a mean of 8.8 (standard deviation, 2.1) years later. OSA severity was described by the apnea-hypopnea index (AHI), mean and minimum nocturnal blood oxygen saturation level (SaO 2 , %), and time with SaO 2 &lt;90%. AHI+1 was log transformed. Participants using positive airway pressure therapy (PAP) at the tonometry visit were evaluated as a distinct categorical variable. Non-invasive applanation tonometry was used to derive aortic (carotid-to-femoral) PWV. Multivariable linear and logistic regression models that included CVD risk factors, antihypertensive, and lipid medications were fit to evaluate longitudinal associations between baseline OSA markers and future PWV. Results: At baseline, the 596 participants were mean 55.9 (7.3) years old (53% male, 97.5% Caucasian). Their mean body-mass index (was 31.4 (6.9) kg/m 2 , 89 (14.9%) had diabetes mellitus, and 252 (42.3%) were hypertensive. Excluding the 40 CPAP users, the mean AHI was 5.8 (7.6) events/hour (range 0.0-53.6); 54 (9.1%) had AHI ≥15 events/hr. Mean SaO 2 was 94.7% (2.1%) and minimum SaO 2 was 82.8% (9.5%). Time with SaO 2 &lt;90% did not predict PWV. In models adjusted for age and sex, lower mean SaO 2 (β=-0.16, SE 0.06, p=0.004), lower minimum SaO 2 (β=-0.04, SE 0.01, p=0.005) and higher log 10 (AHI+1) (β=0.55, SE 0.20, p=0.005) predicted higher PWV a mean of approximately 9 years after OSA assessment. However, none of these associations were statistically significant after waist circumference (p≤0.005 for all 3 outcomes) and height were added to the models. For models with mean SaO 2 , waist circumference independently predicted PWV, but after addition of CVD risk factors, only age (β=0.14, SE 0.01, p&lt;0.001), systolic blood pressure (β=0.02, SE 0.01, p&lt;0.001), and diabetes status (β=0.96, SE 0.28, p=0.002) were independent predictors. Very similar results were observed for models with minimum Sa0 2 and PWV. None of the OSA parameters interacted with age or smoking status to predict PWV. Presence of Metabolic Syndrome did not predict PWV; it did not interact with OSA parameters to predict PWV. Conclusions: The longitudinal associations between OSA and PWV are confounded by body size and influenced by diabetes mellitus and blood pressure. These results suggest that weight management and blood pressure control may help prevent arterial stiffening associated with sleep apnea.
Abstract 15663: A Novel Strategy for Increasing Myocardial Retention of Stem Cells Delivered by Intracoronary Infusion in a Porcine Model of Acute Myocardial Infarction
Authors: Guilherme V Silva, Yi Zheng, Xin Quan, Amir Gahremanpour, Maria G Cabreira, Micheline M Resende, Zakar Mnjoyan, Fred Baimbridge, James T Willerson, Emerson C Perin
Journal: Circulation (2011)

Background The relatively low myocardial retention of intracoronary infused stem cells remains a limitation of stem cell therapy in patients with acute myocardial infarction (AMI). We are the first...
Abstract 15677: Statin Prescription and Dose Intensity Among Elderly Medicare Beneficiaries, by CV Disease Diagnosis and Prescriber Specialty
Authors: Akeem Yusuf, Christopher Wiggenhorn, Jill Hardin, Ryan D Kilpatrick, Charles A Herzog
Journal: Circulation (2014)

Introduction: Statin use is known to benefit elderly patients with cardiovascular (CV) disease. However, little is known about the rate and dose of statin prescriptions or prescriber specialty among elderly Medicare beneficiaries with a history of various CV diseases. Method: In this retrospective analysis of 2007-2010 Medicare claims data, we identified enrollees with history of prevalent CV disease or diabetes (DM) (N=613,674, 68% women, 7.5% black, mean [±SD] age 76.7 [±8] years). We used a disease hierarchy approach and included 9 subgroups: patients with a history of myocardial infarction (MI), unstable angina, ischemic stroke, stable angina, transient ischemic attack (TIA), carotid stenosis, coronary revascularization (PCI/CAB), peripheral arterial disease (PAD), or DM. We identified statin users at diagnosis or within 12 months post-diagnosis; categorized statin therapy as high-, moderate-, and low-intensity; and examined the clinical specialty of statin prescribers. Results: Overall, 41% of patients had at least one cardiologist visit in 2010. Statin use was highest among PCI/CAB patients (81.5%) and lowest among PAD patients (45.5%) (Table 1). Similar proportions of patients with MI (72.8%) and unstable angina (71.4%) were prescribed statins. High-intensity and low-intensity statins were most commonly prescribed to MI patients (22%) and TIA patients (13.7%), respectively. Overall, family/internal medicine was the most common specialty of statin prescribers across all CV disease groups (Table 2). PCI/CAB patients were most likely to receive prescriptions from cardiologists (23.8%). Endocrinologists prescribed 2.3% of statins for DM patients. Most PAD patients (62.9%) were prescribed statins by family/internal medicine clinicians. Conclusions: Statin use is lower among elderly PAD and TIA patients. More comprehensive assessment of statin use is needed, and of its determinants and associated outcomes in elderly CV patients.
Arthritis Pain Guidelines Issued
Authors: Mike Mitka
Journal: JAMA (2002)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal