FATAL APLASTIC ANEMIA DUE TO STREPTOMYCIN: CASE REPORT AND BRIEF REVIEW OF PERTINENT LITERATURE
Authors: C R WOMACK, C B REINER
Journal: Annals of Internal Medicine (1951)

Case Reports1 March 1951FATAL APLASTIC ANEMIA DUE TO STREPTOMYCIN: CASE REPORT AND BRIEF REVIEW OF PERTINENT LITERATUREC. RAY WOMACK, M.D., CHARLES B. REINER, M.D.C. RAY WOMACK, M.D.Search for more papers by this author, CHARLES B. REINER, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-34-3-759 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptStreptomycin was first described over five years ago by Waksman and his coworkers.21 As experience has accumulated regarding its clinical use, manifestations of toxicity have become increasingly and significantly apparent. Depression of the blood-forming organs has been, however, an uncommon occurrence, and only two previous cases of aplastic anemia due to streptomycin are known to have been reported at the time of this communication.Little evidence of toxic effects of streptomycin administration upon the hematopoietic system has been observed in animal studies. Feldman and Hinshaw10noted no effect on hematopoietic tissues or hemoglobin values in tuberculous guinea pigs treated for...Bibliography1. Adcock J: Personal communication to McDermott.15 Google Scholar2. AndersonJewell DGM: The absorption, excretion and toxicity of streptomycin in man, New England J. Med. 233: 485-491, 1945. CrossrefGoogle Scholar3. Bunn PA: Streptomycin in the treatment of human tuberculosis, Dis. Chest 14: 670-681, 1948. CrossrefMedlineGoogle Scholar4. : Streptomycin in the treatment of infections. A report of 1000 cases, J. A. M. A. 132: 70-77, 1946. 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REINER, M.D.*Received for publication March 3, 1949.From the Medical Service, Brooke General Hospital, Fort Sam Houston, Texas.†Present address: Thorndike Memorial Laboratory, Boston City Hospital, Boston, Mass. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byDie Panmyelopathie und andere Formen der PancytopenieMyeloidMyocardial infarction following streptomycin anaphylactic reactionStreptomycin and Dihydrostreptomycin: Applied PharmacologyCHANGING OF DISEASE PATTERNS: DISAPPEARANCE OF DISEASES: NEW DISEASESComplications of antibiotic therapyUntoward Reactions to AntibioticsALLERGY, ANTIBIOTICS AND CHEMOTHERAPEUTICSDRUG INDUCED HYPOPLASTIC ANEMIAS AND RELATED SYNDROMES*EDWIN E. OSGOOD, M.D., F.A.C.P.Hemocytopenic Reactions to Modern DrugsFatal Aplastic Anemias from Chloramphenicol 1 March 1951Volume 34, Issue 3Page: 759-767KeywordsAplastic anemiaGuinea pigsHemoglobinMedical servicesResearch laboratoriesStreptomycinToxicity ePublished: 1 December 2008 Issue Published: 1 March 1951 PDF downloadLoading ...