tbuckley/cabot-search huggingface dataset:
Human breast cancer: prognostic significance of the c-erbB-2 oncoprotein compared with epidermal growth factor receptor, DNA ploidy, and conventional pathologic features.
Authors: G Gasparini, W J Gullick, P Bevilacqua, J R Sainsbury, S Meli, P Boracchi, A Testolin, G La Malfa, F Pozza
Journal: Journal of Clinical Oncology (1992)

PURPOSE A study was undertaken to define the prognostic value of the expression of the c-erbB-2 oncoprotein in a series of breast cancer patients when compared by multivariate analysis with expression of the epidermal growth factor receptor (EGFR), DNA ploidy, and conventional clinicopathologic features. PATIENTS AND METHODS Prognostic indicators were analyzed in 165 primary breast cancers. The c-erbB-2 oncoprotein was recognized by the polyclonal antibody 21N using an immunocytochemical method. Expression of the EGFR was stated immunocytochemically using the monoclonal antibody EGFR1. DNA ploidy was assessed in paraffin-embedded sections using a standard flow-cytometric method. RESULTS Overall, 27% of carcinomas had membrane 21N-staining and were classified as c-erbB-2-positive. Overexpression of the c-erbB-2 oncoprotein was poorly associated with EGFR expression and the conventional pathologic features, and it was weakly associated with DNA ploidy and nodal status. Univariate analysis showed that c-erbB-2 expression, nodal status, DNA ploidy, and EGFR provided significant prognostic information concerning 4-year relapse-free survival (RFS) with the odds ratios (ORs) of not relapsing of 2.94, 2.83, 2.34, and 2.20, respectively. Regarding overall survival (OS) at 4 years, only nodal status and DNA ploidy had prognostic significance, with the ORs of not dying of 2.68 and 2.80, respectively. Applying multivariate analysis to RFS, 21N when adjusted for nodal status, EGFR, and DNA ploidy (full model) failed to retain prognostic value (P = .202), whereas nodal status was the most significant indicator of relapse (P = .027) followed by DNA ploidy (P = .056) and EGFR (P = .093). CONCLUSIONS This study suggests that overexpression of the c-erbB-2 oncoprotein appears to be an important indicator of relapse in stage I-II breast cancer when singly evaluated. Multivariate analysis shows that the determination both of nodal status and DNA ploidy improves our ability to identify subsets of patients with different prognoses, and allows for a better selection of patients for systemic adjuvant treatments.
Abstract 12621: The Acquired and the Inherited Form of the LQT2 Syndrome are associated with different Abnormal T-wave Morphology
Authors: Jean-Philippe Couderc, Xiajuan Xia, Derick Peterson, Scott McNitt, Wojciech Zareba, Arthur J Moss
Journal: Circulation (2010)

A similar mechanism is present in the congenital LQT2 patients and in individuals exposed to non-cardiac arrhythmogenic drugs associated with Ikr blockade. We investigated specific T-wave morpholog...
Cutaneous lupus erythematosus and the association with systemic lupus erythematosus: a population-based cohort of 1088 patients in Sweden
Authors: C.M. Grönhagen, C.M. Fored, F. Granath, F. Nyberg
Journal: British Journal of Dermatology (2011)

Studies reporting the incidence of isolated cutaneous lupus erythematosus (CLE) are rare.To examine in a population-based cohort study the incidence of CLE and its subsets in Sweden. The short-term probability of receiving an additional diagnosis of systemic lupus erythematosus (SLE) is also assessed.A population-based open cohort study including all patients with CLE [International Classification of Diseases (ICD) code, ICD-10: L93] in Sweden, 2005-2007. Patients (n=1088) were identified in the Swedish National Patient Register.The incidence of CLE was 4·0/100,000; the female/male ratio was 3:1. Mean age at disease onset was 54 years. The most common subset was discoid lupus erythematosus (DLE) (80%, n = 868). A quarter of the patients (24%, n=260) were already diagnosed with SLE at the time they were diagnosed with CLE. During the whole observation period (2005-2007), an additional 18% (n = 107) were diagnosed with SLE, the probability of receiving an additional SLE diagnosis being highest for the subacute CLE (SCLE) subset.This is the first nationwide epidemiological study on CLE. We found the incidence of CLE to be about equal to that of SLE, and found a higher short-term probability for receiving an additional diagnosis with SLE than previously described for CLE. Subsets other than DLE and SCLE were rarely reported in our system; an update of the ICD codes for this diagnostic group could increase reporting of these more unusual cases. Our study clarifies that monitoring and follow-up are called for in this patient group due to the risk for SLE, and underscores the need for clear criteria for risk assessment in the large group of patients with CLE who also fulfil criteria for SLE.
How can we improve the rate of autopsies among Muslims?
Authors: Mudher Al-Adnani, Irene Scheimberg
Journal: BMJ (2006)

A mong Muslim people in Britain the uptake of autopsies in general, and perinatal and paediatric autopsies in particular, is low. Family members may decline consent for an autopsy for several reasons: they believe that Islam doesn't allow autopsy; they see no need for an autopsy because of their belief that death is God's will; advances in medical knowledge mean that everything is already known about the case and hence an autopsy isn't necessary; they fear that the body will be desecrated; and they worry that an autopsy will prevent the body from being buried as soon as possible, an Islamic requirement. Are these reasons justified?

Islamic law is derived from three sources: the Koran, the Sunnah—which includes the teachings, whether by word or deed, of Mohammed—and ijtihad, the process of deductive logic. The laws set by the Koran and Sunnah are obligatory for all Muslims and cannot be disputed. Ijtihad opinion is formulated by a single scholar or group of scholars who reach a consensus. The ruling, called a fatwa, is not binding. It can be right or wrong and can be debated and modified, so a range of views on a given question is possible.

> Although death is …
Osteoprotegerin, body composition and cardiovascular risk in sleep apnea syndrome
Authors: Monika Kosacka, Anna Korzeniewska, Renata Jankowska
Journal: European Respiratory Journal (2012)

Obstructive sleep apnea syndrome (OSAS) is a frequent disease associated with increased risk of cardiovascular disorders. The aim of this study was the evaluation of changes in osteoprotegerin serum levels and in body composition parameters in patients with sleep apnea syndrome.

We examinated 47 patients with OSAS (mean age 55,42 ±7,91, mean AHI 32,76 ±19,98) and 29 persons from control group (mean age 49,48 ±13,68). All subjects underwent bioelectrical impedance analysis with a single-frequency bioimpedance analyzer (Model BIA 101 Akern) and polysomnography Grass Aura Lite. The osteoprotegerin serum level was measured using a ELISA kit: Human Osteoprotegerin (R&D Systems).

We didn't showed either differences in osteprotegerin serum levels between OSAS patients and control group (4,696 vs 4,631 pmol/l, p=0,680) nor correlations between osteoprotegerin and AHI (p=0,484, R=0,08). Moreover we didn't find changes in osteprotegerin levels in OSAS patients with diabetes (p=0,251), with hypertension (0,911) or ischemic heart disease (0,876).

We observed higher BMI in OSAS patients (p=0,009),but from all body composition parameters we revealed only lower phase angle in OSAS patients (5,65, vs 5,87,p=0,047). We evaluated the relationships between osteoprotegerin and body composition parameters and we found only tendency, that osteoprotegerin level correlated negative with muscle mass percentage (MM%) (p=0,069, R=-0,209) and positive with fat mass percentage FM%. CRP was significant higher in OSAS than in control group (6,59 vs 3,85 p=0,006).R=0,198,p=0,08), but we didn't find correlations between osteoprotegerin and CRP (p=0,929, R=0,010).

Our study didn't show changes in osteoprotegerin in OSAS patients.
A randomized trial of the effects of early cardiac serum marker availability on reperfusion therapy in patients with acute myocardial infarction
Authors: W.Brian Gibler, James W. Hoekstra, W.Douglas Weaver, Mitchell W. Krucoff, Alfred P. Hallstrom, Raymond E. Jackson, Michael R. Sayre, James Christenson, George L. Higgins, Grant Innes, Richard J. Harper, Gary P. Young, Nathan R. Every
Journal: Journal of the American College of Cardiology (2000)
Oral contraceptives and the periodontium
Authors: Philip M. Preshaw
Journal: Periodontology 2000 (2012)

Abstract Oral contraceptives are a safe and effective means of contraception for millions of women worldwide. The first formulations of these drugs contained much higher doses of estrogens and progestins than those available today, and these were associated with an unacceptably high rate of unwanted effects including serious cardiovascular events. In addition, a number of case reports and clinical studies suggested that use of the first generation oral contraceptives was also associated with an increased risk for gingival and/or periodontal disease. Unfortunately, many of these early studies suffered from significant methodological flaws which throw their findings into question. Nonetheless, these studies provided the basis for a perception among the dental profession that oral contraceptives increase the risk for gingivitis and/or periodontitis. Realisation that the adverse events profile of oral contraceptives was dose dependant led to the development of the modern low dose formulations that are in use today. There have been far fewer studies to investigate whether modern oral contraceptives have any impact on the periodontium compared to studies of the early contraceptive formulations, but the quality of the more recent research is undoubtedly better. Following extensive review of the relevant literature and consideration of the historical perspective, the best available evidence strongly supports that oral contraceptives no longer place users at any increased risk for gingivitis or periodontitis. Oral contraceptives should not be viewed as a risk factor for gingival or periodontal disease.
Response: high ERG gene expression is an unfavorable prognostic marker in pediatric acute myeloid leukemia
Authors: Anna Staffas, Meena Kanduri, Randi Hovland, Richard Rosenquist, Hans Beier Ommen, Jonas Abrahamsson, Erik Forestier, Kirsi Jahnukainen, Ólafur G. Jónsson, Bernward Zeller, Josefine Palle, Gudmar Lönnerholm, Henrik Hasle, Hans Ehrencrona, Lars Palmqvist
Journal: Blood (2012)
Clinical features and studies of erythropoiesis in Israeli Bedouins with congenital dyserythropoietic anemia type I
Authors: H Tamary, H Shalev, D Luria, D Shaft, M Zoldan, L Shalmon, A Gruinspan, B Stark, M Chaison, E Shinar, P Resnitzky, R Zaizov
Journal: Blood (1996)
Abstract 4509: Cardiac Catheterization as a Strategy for Pre-Operative Risk Stratification in Patients Undergoing Liver Transplantation
Authors: Inder M Singh, Patrick S Antoun, Timothy J Shoemaker, Colin Terry, Paul Y Kwo, Joseph A Tector, Jeffrey A Breall, Saihari Sadanandan
Journal: Circulation (2008)

Liver transplantation (LT) is considered a high risk surgery due to the hemodynamic and cytokine stress on the recipient coronary arteries. Limited data exists on the role of cardiac catheterizatio...
Evaluating Research on the Safety of Medical Therapies
Authors: Phil B. Fontanarosa, Howard Bauchner, Robert M. Golub
Journal: JAMA (2015)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Mechanisms of MicroRNAs in Atherosclerosis
Authors: Andreas Schober, Christian Weber
Journal: Annual Review of Pathology Mechanisms of Disease (2016)

The maladaptation of endothelial cells to disturbed flow at arterial bifurcations increases permeability for lipoproteins. Additional injury by chemically modified lipoproteins disrupts the continuous repair of maladapted endothelial cells and triggers intimal macrophage accumulation. Macrophages remove modified lipoproteins from the extracellular space until the cholesterol overload leads to macrophage death and insufficient efferocytosis. This macrophage failure promotes the progression to advanced lesions by formation of a lipid-rich necrotic core, which may rupture and cause myocardial infarction and stroke. In this article, we summarize the fundamental roles of microRNAs (miRNAs) in the regulation of endothelial maladaptation and macrophage failure during atherosclerosis. We describe how miRNAs coordinate the mutual interaction between chronic endothelial repair and endothelial senescence and mechanistically link the regulation of macrophage cholesterol homeostasis with defective efferocytosis. Lastly, we discuss how miRNAs may challenge and extend current theories about atherosclerosis.
Positive effects of carbamazepine on behavioral dyscontrol in borderline personality disorder
Authors: D L Gardner, R W Cowdry
Journal: American Journal of Psychiatry (1986)

In a double-blind crossover trial, carbamazepine, an anticonvulsant with primary effects on subcortical limbic structures, decreased the severity of behavioral dyscontrol in 11 women with borderline personality disorder significantly more than placebo. The authors emphasize the preliminary nature of their findings and discuss alternative hypotheses regarding mechanisms by which carbamazepine might influence behavioral dyscontrol.
The Hysterical Personality in Men
Authors: PAUL V. LUISADA, ROGER PEELE, ELIZABETH A. PITTARD
Journal: American Journal of Psychiatry (1974)

The authors studied case records of 27 men who had been diagnosed as having hysterical personality, although they note that the current literature assumes that the diagnosis of hysterical personality applies predominantly to women. They believe that not recognizing the hysterical personality in men is not only a common diagnostic error but antitherapeutic and counterproductive as well.
Management of Cancer Pain
Authors: Allen W. Burton, Arun Rajagopal, Charles S. Cleeland, Samuel J. Hassenbusch, Daniel B. Carr
Journal: JAMA (2004)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
A correlation of erythrokinetics, ineffective erythropoiesis, and erythroid precursor apoptosis in Thai patients with thalassemia
Authors: Pensri Pootrakul, Pornpan Sirankapracha, Surai Hemsorach, Wanna Moungsub, Rawiprapa Kumbunlue, Anong Piangitjagum, Prawase Wasi, Lisa Ma, Stanley L. Schrier
Journal: Blood (2000)
Myasthenic crisis following cisplatin chemotherapy in a patient with malignant thymoma.
Authors: Y Solak, O Dikbas, K Altundag, N Guler, Y Ozisik
Journal: Journal of experimental & clinical cancer research (2004)

Malignant thymomas are associated with numerous autoimmune disorders including myasthenia gravis. Myastenia gravis is characterized by antibodies against the acetylcholine receptors located on the neuromuscular junction of the skeletal muscle. We present a case with malignant thymoma who developed myasthenia crisis while he was treated with cisplatin chemotherapy.
Colon Cancer
Authors: Paul F. Engstrom, Juan Pablo Arnoletti, Al B. Benson, Yi-Jen Chen, Michael A. Choti, Harry S. Cooper, Anne Covey, Raza A. Dilawari, Dayna S. Early, Peter C. Enzinger, Marwan G. Fakih, James Fleshman, Charles Fuchs, Jean L. Grem, Krystyna Kiel, James A. Knol, Lucille A. Leong, Edward Lin, Mary F. Mulcahy, Sujata Rao, David P. Ryan, Leonard Saltz, David Shibata, John M. Skibber, Constantinos Sofocleous, James Thomas, Alan P. Venook, Christopher Willett
Journal: Journal of the National Comprehensive Cancer Network (2009)

OverviewColorectal cancer is the fourth most frequently diagnosed cancer and the second leading cause of cancer death in the United States.In 2009, an estimated 106,100 new cases of colon and 40,870 cases of rectal cancer will occur.During the same year, it is estimated that 49,920 people will die from colon and rectal cancer. 1 Despite these statistics, mortality from colon cancer has decreased slightly over the past 30 years, possibly due to earlier diagnosis through screening and better treatment modalities.
Structured interview data on 102 cases of multiple personality disorder from four centers
Authors: C A Ross, S D Miller, P Reagor, L Bjornson, G A Fraser, G Anderson
Journal: American Journal of Psychiatry (1990)

Patients with multiple personality disorder (N = 102) at four different centers were interviewed with the Dissociative Disorders Interview Schedule. The presenting characteristics of the patients at all four centers were very similar. The clinical profile that emerged included a history of childhood physical and/or sexual abuse in 97 (95.1%) of the cases. The subjects reported an average of 15.2 somatic symptoms, 6.4 Schneiderian symptoms, 10.2 secondary features of the disorder, 5.2 borderline personality disorder criteria, and 5.6 extrasensory experiences; their average score on the Dissociative Experiences Scale was 41.4. The results indicate that multiple personality disorder has a stable, consistent set of features.
Effectiveness of national standardized and WHO regimens and risk factors of unfavorable outcomes in treatment of patients with MDR-TB in Novosibirsk Oblast, Russian Federation
Authors: Yana Batyrshina, Tatyana Petrenko
Journal: European Respiratory Journal (2014)

Background:  High prevalence of MDR-TB in Novosibirsk Oblast (NO) (61,0 on 100000 population in 2012) requires for search of optimal treatment regimens for these patients.   Aims:  To evaluate outcomes of MDR-TB treatment with use of WHO regimens and 4th regimen of national standard of MDR-TB therapy. To define risk factors (RF) of unfavorable outcomes.   Methods:  Retrospective cohort study. The sample is –341 patients with newly diagnosed MDR-TB, residents of NO, treated with use of mentioned regimens in 2005-2010. Outcomes were defined after completed treatment course as a cure (culture conversion) and unfavorable (failure, death) with follow-up time 1-3 years in 202 patients. Collected clinical and socio-demographic patients9 data were evaluated for potential RF of unfavorable outcomes by odds ratio (OR) with 95%CI calculation.   Results:  268(78,6%) patients were cured, 14(4,1%) died during treatment and 59(17,3%) had treatment failure. Relapses occurred in 14 of 146 cured (9,6%), 9 of 56 patients with treatment failure (16,1%) died during follow-up time. RF of unfavorable outcomes were: smear positivity (OR 3,0(1,7-5,3), p=0,0001), pulmonary lesions > 2 segments (OR 5,7(2,8-11,5), p   Conclusions:  Treatment outcomes depend on severity of TB process and patient adherence to therapy and may be improved by early TB diagnostics and increasing tolerance especiallyamong socially maladjusted patients.
Drug points: Artificial colourings and adverse reactions
Authors: L Gracey-Whitman, S Ell
Journal: BMJ (1995)

Drs L GRACEY-WHITMAN and S ELL (Queen Elizabeth Hospital, King's Lynn, Norfolk PE30 4ET) write: An 80 year old man with membranous glomerulonephritis was reviewed in clinic after an emergency admission in heart failure. His prednisolone, nizatidine, and amiloride were stopped, his frusemide was halved to 80 mg once daily, and his enalapril was increased from 5 mg to 10 mg once daily. One week later, he developed a widespread, pruritic maculopapular rash. The patient's wife (who had read the fine print of the data sheet) noted …
Abstract 298: Development of a Pediatric Field Trauma Triage Algorithm for Identifying Children With Serious Injuries or Need for Major Surgical Intervention
Authors: Craig Newgard, Thomas Rea, Eileen Bulger, Ross Fleischman, Ewen Wang, Renee Hsia, Craig Warden, Michael Liao, Ritu Sahni, Clay Mann, Nathan Kuppermann
Journal: Circulation (2010)
Mutations in a Large Cohort of Young Adult Patients with Core Binding Factor Acute Myeloid Leukemia: Impact on Outcome and the Selection of Patients for Alternative Treatment Including Transplantation in First Complete Remission
Authors: Christopher G Allen, Robert K Hills, Catherine M Evans, Katarina Lamb, Rob Sellar, Anthony V Moorman, Michelle Sale, John Ahman Liu-Yin, Alan K Burnett, David C Linch, Rosemary E Gale
Journal: Blood (2011)
Hospital-based policies for prevention of perinatal group B streptococcal disease-United States, 1999.
Authors: P. Daily, L. Gelling, G. Rothrock, A. Reingold, D. Vugia, H. Linardos, A. Roome, C. Morin, Q. Phan, J. L. Hadler, W. Baughman, M. Farley, D. Stephens, P. Blake, M. Pass, L. Harrison, J. C. Roche, J. Rainbow, R. Lynfield, R. Danila, B. Damaske, D. Morse, N. Bennett, P. Smith, L. Duke, K. . Stefonek
Journal: MMWR Morbidity and Mortality Weekly Report (2000)
Second cancers and late toxicities after treatment of aggressive non-Hodgkin lymphoma (NHL) with the ACVBP regimen. A GELA (Groupe d'Etude des Lymphomes de l'Adulte) cohort study on 2849 patients.
Authors: Marc André, N. Mounier, X Leleu, Anne Sonet, P. Brice, H. Tilly, B. Coiffier, André Bosly, Priscilla Morel, C. Haioun, P. Gaulard, C. Gisselbrecht
Journal: Blood (2001)
Cytogenetic profile of B-cell chronic lymphoproliferative disorders displaying TCR gene rearrangements.
Authors: Lucienne Michaux, M. Stul, Jm. Hernandez, Erp Velloso, J. Dierlamm, A. Vanorshoven, A. Criel, André Bosly, Jl. Michaux, C. Dewolfpeeters, Jj. Cassiman, C. Mecucci, Hans Vandenberghe
Journal: Blood (1995)
Loss of the Rap1 effector RIAM results in leukocyte adhesion deficiency due to impaired β2 integrin function in mice
Authors: Sarah Klapproth, Markus Sperandio, Elaine M. Pinheiro, Monika Prünster, Oliver Soehnlein, Frank B. Gertler, Reinhard Fässler, Markus Moser
Journal: Blood (2015)