A FURTHER REPORT ON THE TREATMENT OF ADDISON'S DISEASE WITH DESOXYCORTICOSTERONE ACETATE BY INTRAMUSCULAR INJECTIONS, SUBCUTANEOUS IMPLANTATION OF PELLETS, AND SUBLINGUAL ADMINISTRATION
Authors: Frank L. Engel, Clarence Cohn, Louis J. Soffer
Journal: Annals of Internal Medicine (1942)

Article1 October 1942A FURTHER REPORT ON THE TREATMENT OF ADDISON'S DISEASE WITH DESOXYCORTICOSTERONE ACETATE BY INTRAMUSCULAR INJECTIONS, SUBCUTANEOUS IMPLANTATION OF PELLETS, AND SUBLINGUAL ADMINISTRATIONFRANK L. ENGEL, M.D., CLARENCE COHN, M.D., LOUIS J. SOFFER, M.D.FRANK L. ENGEL, M.D.Search for more papers by this author, CLARENCE COHN, M.D.Search for more papers by this author, LOUIS J. SOFFER, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-17-4-585 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptSince the original reports by Levy-Simpson1and Thorn2, 3, 4on the use of desoxycorticosterone acetate in the treatment of Addison's disease, many further reports have appeared confirming its value and pointing out its limitations and toxic effects resulting from overdosage.5, 6, 7In 1939 an advance in therapy was made by Thorn and his co-workers8, 9who utilized the technic of Deanesly and Parkes10and maintained adrenalectomized dogs and patients with Addison's disease in good condition by implantation of pellets of crystalline desoxycorticosterone acetate subcutaneously. By this method a slow and steady release of hormone, calculated at about 0.2...Bibliography1. 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WILLSONRYNEARSONDRY OMEHTJ: Cardiac failure following treatment of Addison's disease with desoxycorticosterone acetate, Proc. Staff Meet. Mayo Clin., 1941, xvi, 168. Google Scholar19. WILDER RM: Progress in the treatment of Addison's disease, Proc. Staff Meet. Mayo Clin., 1940, xv, 273. Google Scholar20. TOOKEPOWERKEPLER TBMHEJ: Tolerance for potassium of patients with Addison's disease treated with desoxycorticosterone acetate, Proc. Staff Meet. Mayo Clin., 1940, xv, 365. Google Scholar21. KUHLMANNRAGANFERRABEEATCHLEYLOEB DCJWDWRF: Toxic effects of desoxycorticosterone esters in dogs, Science, 1939, xc, 496. CrossrefGoogle Scholar22. FERREBEERAGANATCHLEYLOEB JWCDWRF: Comparison of desoxycorticosterone, corticosterone and cortical extract in the treatment of a patient with Addison's disease, Endocrinology, 1940, xxvii, 360. CrossrefGoogle Scholar23. THORNKOEPFLEWISOLSEN GWGFRAEF: Carbohydrate metabolism in Addison's disease, Jr. Clin. Invest., 1940, xix, 813. CrossrefGoogle Scholar24. INGLE DJ: The work performance of adrenalectomized rats treated with corticosterone and related compounds, Endocrinology, 1940, xxvi, 472. CrossrefGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: New York, N. Y.*Received for publication December 22, 1941.From the Medical Services of The Mount Sinai Hospital, New York City.The desoxycorticosterone acetate (Percorten) was generously supplied and manufactured by the Ciba Pharmaceutical Co., Summit, N. J.†Eugene Meyer, Jr. Fellow. Nextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byTHE DIAGNOSIS AND TREATMENT OF ADDISON'S DISEASEA Study of Sublingual Absorption I. 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