SICKLE CELL-HEMOGLOBIN D DISEASE
Authors: E W SMITH, C L CONLEY
Journal: Annals of Internal Medicine (1959)

Article1 January 1959SICKLE CELL-HEMOGLOBIN D DISEASEERNEST W. SMITH, C. LOCKARD CONLEY, F.A.C.P.ERNEST W. SMITHSearch for more papers by this author, C. LOCKARD CONLEY, F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-50-1-94 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptSoon after the discovery that sickle (S) hemoglobin can be differentiated from normal (A) hemoglobin by electrophoresis,1other abnormalities of hemoglobin were recognized. In studying a white patient who previously had been thought to have sickle cell anemia, Itano2found that the erythrocytes of the mother could not be made to sickle, although the electrophoretic pattern was indistinguishable from that of sickle cell trait. The abnormal hemoglobin which did not produce sickling also differed from S hemoglobin because of its normal solubility in the reduced state, and was subsequently designated ashemoglobin D. The atypical hemolytic disorder in the patient...Bibliography1. PaulingItanoSingerWells LHASJIC: Sickle cell anemia, a molecular disease, Science 110: 543, 1949. CrossrefMedlineGoogle Scholar2. Itano HA: A third abnormal hemoglobin associated with hereditary hemolytic anemia, Proc. Nat. Acad. Sc. 37: 775, 1951. CrossrefMedlineGoogle Scholar3. CabannesSendraDalaut RL: Hemoglobin D—a hereditary hemoglobin abnormality in an Algerian Mussulman—observations of two families, Algérie méd. 59: 387, 1955. MedlineGoogle Scholar4. AksoyLehmann MH: A further example of hemoglobin D in a Turkish family, Tr. Roy. Soc. Trop. Med. and Hyg. 50: 178, 1956. CrossrefMedlineGoogle Scholar5. BirdLehmann GWH: Letter to the editor: Hemoglobin D in India, Brit. M. J. 1: 514, 1956. CrossrefGoogle Scholar6. BirdIkinLehmannMourant GWEWHAE: The blood groups and hemoglobins of the Sikhs, Heredity 10: 425, 1956. CrossrefGoogle Scholar7. Chernoff AI: On the prevalence of hemoglobin D in the American Negro, Blood 11: 907, 1956. CrossrefMedlineGoogle Scholar8. SmithTorbert EWJV: Unpublished observations. Google Scholar9. HynesLehmann MH: Hemoglobin D in a Persian girl: presumably the first case of hemoglobin D-thalassemia, Brit. M. J. 2: 923, 1956. CrossrefMedlineGoogle Scholar10. BirdLehmann GWH: The findings of hemoglobin D disease in a Sikh, Man 55: 1, 1956. CrossrefGoogle Scholar11. Dacie JV: The hemolytic anemias—congenital and acquired, 1954, Grune and Stratton, New York, p. 146. Google Scholar12. StewartMacIver JNJE: Sickle cell-hemoglobin D disease in a mulatto girl, Lancet 1: 23, 1956. CrossrefGoogle Scholar13. SturgeonItanoBergren PHAWR: Clinical manifestations of inherited abnormal hemoglobins. I. The interaction of hemoglobin S with hemoglobin D, Blood 10: 389, 1955. CrossrefMedlineGoogle Scholar14. RobinsonRobsonHarrisonZuelzer ARMAPWW: A new technique for differentiation of hemoglobin, J. Lab. and Clin. Med. 50: 745, 1957. MedlineGoogle Scholar15. SmithConley EWCL: Filter paper electrophoresis of human hemoglobins with special reference to the incidence and clinical significance of hemoglobin C, Bull. Johns Hopkins Hosp. 93: 94, 1953. MedlineGoogle Scholar16. HaynieDobsonHettig TPHLRA: Molecular diseases of hemoglobin: introduction and incidence, Ann. Int. Med. 46: 1031, 1957. LinkGoogle Scholar17. SilverSimonClement HKJLDG: Salmonella osteomyelitis and abnormal hemoglobin disease, Pediatrics 20: 439, 1957. MedlineGoogle Scholar18. Hammond D: Salmonella osteomyelitis and abnormal hemoglobin disease, Pediatrics 21: 162, 1958. Google Scholar19. SmithConley EWCL: Clinical features of the genetic variants of sickle cell disease, Bull. Johns Hopkins Hosp. 94: 289, 1954. MedlineGoogle Scholar20. ShelleyCurtis WHEM: Bone marrow embolism in sickle cell anemia and sickle cell-hemoglobin C disease, Bull. Johns Hopkins Hosp. 103: 8, 1958. MedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Baltimore, Maryland*Received for publication October 28, 1957.From the Department of Medicine, The Johns Hopkins University School of Medicine and Hospital.†Department of Medicine of the Howard Hughes Medical Institute.This investigation was supported in part by a Research Grant of the Division of Research Grants and Fellowships, National Institutes of Health.Requests for reprints should be addressed to Ernest W. Smith, M.D., Assistant Professor of Medicine, The Johns Hopkins Hospital, Baltimore 5, Maryland. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byClinical, hematological and genetic data of a cohort of children with hemoglobin SDHbSD-PunjabFirst Report of Successful Stem Cell Transplantation in a Patient With Sickle Cell Hemoglobin D DiseaseInternational Hemoglobin Information Center Variant ListHB D-Punjab in the United Arab EmiratesHydroxyurea and Sickle Cell Anemia Clinical Utility of a Myelosuppressive “Switching” AgentVariants of the Alpha ChainInternational Hemoglobin Information CenterHB D-Neath or β121 (GH4) GLU→ALA: A New Member of the HB D FamilyVariants of the Alpha ChainInternational hemoglobin information center: Variants of the alpha chainInternational Hemoglobin Information CenterVariants of the Alpha ChainIHIC Variants ListHB D-Los Angeles in Brazil: Simple Heterozygotes and Associations with β-Thalassemia and Kith HB SIHIC Variants ListInternational Hemoglobin Information Center IHIC Variants ListPregnancy in Sickle Cell DiseaseInternational Hemoglobin Information CenterLife-Twieatening Complications in a Child with Hemoglobin Sd-Los Angeles DiseaseInternational Hemoglobin Information Center: Policies—IhicInternational Hemoglobin Information Center Policies - IHICInternational Hemoglobin Information Center Policies - IhicHematological and Clinical Features of Sickle Cell Diseases: a ReviewInternational Hemoglobin Information Center: Policies -Ihicβ-Chain Variants in Jamaican NewbornsVariant ListsInternational Hemoglobin Information CenterThe Concentration Dependence of the Oxygen Affinity of Haemoglobin SHaemoglobin D Punjab (D Los Angeles)Aseptic necrosis of the femoral head in a white boy with S-D hemoglobinopathyALLELISM, NON-ALLELISM, AND GENETIC COMPOUNDS AMONG THE MUCOPOLYSACCHARIDOSESHemoglobin O Arab in Four Negro Families and Its Interaction with Hemoglobin S and Hemoglobin CInfarction of Bone Marrow in the Sickle Cell DisordersSAMUEL CHARACHE, M.D., DAVID L. PAGE, M.D.Hemoglobin S-D DiseaseM. J. CAWEIN, M.D., E. J. LAPPAT, M.D., R. W. BRANGLE, M.D., C. H. FARLEY, M.D.Sickle Cell Hemoglobin D Disease in a Negro Colombian PatientALBERTO M. RESTREPO, M.D., OSCAR G. LONDOÑO, M.D.Abnormal human haemoglobins VIII. chemical studies on haemoglobin DHämoglobin DHereditary persistence of fetal hemoglobinMedical genetics 1959Clinical and Physiologic Studies in a Negro with Sickle-Cell Hemoglobin D Disease 1 January 1959Volume 50, Issue 1Page: 94-105KeywordsAnemiaFellowshipsGeneticsHemoglobinHospital medicinePneumonitisResearch grantsStem cells Issue Published: 1 January 1959 PDF downloadLoading ...