tbuckley/cabot-search huggingface dataset:
Impact of age on outcome of patients with cancer undergoing autologous bone marrow transplant.
Authors: C B Miller, S Piantadosi, G B Vogelsang, D C Marcellus, L Grochow, M J Kennedy, R J Jones
Journal: Journal of Clinical Oncology (1996)

PURPOSE We examined the impact of age on outcomes in patients with cancer undergoing autologous bone marrow transplantation (ABMT). PATIENTS AND METHODS All 506 adult patients who underwent ABMT at the Johns Hopkins Oncology Center between January 1987 and January 1994 were studied. A total of 405 patients were aged 18 to 49 years and 101 were aged &gt; or = 50. The effect of age and other prognostic variables on transplant-related mortality (TRM), relapse, and event-free survival rates were analyzed. RESULTS Patients aged &gt; or = 50 years has a 2.24-fold increased risk of TRM. Although relapse rates were not different based on age, the increased TRM rate resulted in a slight decrease in overall event-free survival in the older patients. Causes of death were not different by age and were mainly related to preparative regimen toxicity. Length of hospital stay and hospitalization costs were not increased in the older patients. CONCLUSION While the TRM rate was higher in older patients, relapse rates were not increased. Nearly 25% of older patients were expected to be cured of the disease. These data support the use of ABMT in eligible older patients, at least up to the age of 65.
Abstract 15739: Effects of Ranolazine on Long QT3 Syndrome are Mutation Dependent
Authors: Dan Hu, Hector Barajas-Martinez, Lei Ruan, Ryan Pfeiffer, Elena Burashnikov, Gabriel Caceres, Luiz Belardinelli, Charles Antzelevitch
Journal: Circulation (2011)

AIM: Long QT syndrome type 3 (LQT3) is attributable to mutations in SCN5A (Nav1.5) causing an increase in late sodium channel current (INa,L) and leading to delayed ventricular repolarization and T...
Mutations in the homeobox gene HESX1/Hesx1 associated with septo-optic dysplasia in human and mouse
Authors: Mehul T. Dattani, Juan-Pedro Martinez-Barbera, Paul Q. Thomas, Joshua M. Brickman, Raj Gupta, Inga-Lill Mårtensson, Håkan Toresson, Margaret Fox, Jerry K. H. Wales, Peter C. Hindmarsh, Stefan Krauss, Rosa S. P. Beddington, Iain C. A. F. Robinson
Journal: Nature Genetics (1998)
Living longer with pancreatic cancer: More than FOLFIRINOX?
Authors: Phillip Chae, Punam Punja, Nate Koutlas, Prashanti Atluri
Journal: Journal of Clinical Oncology (2015)

476 Background: Effective treatment for uresectable locally advanced pancreatic cancer (LAPC) or metastatic pancreatic cancer is limited and has a poor prognosis with a five year survival rate of 6.7%. FOLFIRINOX has been studied as a neoadjuvant therapy for LAPC and has a response rate of 32%. We set out to investigate which factors, if any, have a meaningful impact on time to disease progression within this cohort of patients. Methods: A retrospective chart review was conducted. All patients who recieved FOLFIRINOX at our institution from 2011-2014 were included. 16 of 19 had unresectable LAPC or metastatic disease at time of diagnosis. A few recieved FOLFIRINOX upon first progression after adjuvant therapy. Results: See Table. Conclusions: Novel approaches are being used to get patients to R0 resection if they have borderline resectable pancreatic cancer or unresectable LAPC consisting of combination chemotherapy followed by radiation. Metastatic patients or unresectable LAPC who do not undergo surgery have limited survival. Reviewing our data we found that the addition of radiation in the metastatic setting may impact time to progression as determined by RECIST criteria. Of the three patients who had the longest time to progression, two were metastatic and both underwent palliative RT to the primary pancreatic lesion. Incorporation of RT to the primary lesion upon completion of FOLFIRINOX therapy should be considered as an innovative approach to increase time to progression and potentially progression free survival and overall survival. Clinical trials randomizing selected patients with metastatic or unresected LAPC to FOLFIRINOX followed by RT versus no RT should be considered. [Table: see text]
K33-linked polyubiquitination of Zap70 by Nrdp1 controls CD8+ T cell activation
Authors: Mingjin Yang, Taoyong Chen, Xuelian Li, Zhou Yu, Songqing Tang, Chen Wang, Yan Gu, Yanfang Liu, Sheng Xu, Weihua Li, Xuemin Zhang, Jianli Wang, Xuetao Cao
Journal: Nature Immunology (2015)
Mother fails in bid to use dead daughter's frozen eggs
Authors: C. Dyer
Journal: BMJ (2015)

A mother’s request to use her dead daughter’s frozen eggs to try to give birth to her own grandchild has been turned down by the High Court.

The 59 year old woman, referred to in court as IM, claimed that her only child, whose eggs were frozen before chemotherapy for bowel cancer, “wanted her genes to be carried on.” Her daughter, referred to as AM, was given the diagnosis at the age of …
Don’t forget standing blood pressure
Authors: Daniel A Jones, Farhad Huwez
Journal: BMJ (2008)

<h3>Objective:</h3> To identify the rate of successful antiepileptic drug (AED) withdrawal after resective surgery and the predictors of postwithdrawal seizure recurrence in patients with extratemporal epilepsy. <h3>Methods:</h3> We retrospectively analyzed the postoperative AED profile of 106 consecutive patients who had completed 2 or more years after resections involving frontal, parietal, and occipital lobes for AED-resistant epilepsy. To identify the potential predictors of seizure recurrence, we compared the attributes of recurred and nonrecurred groups by univariate and multivariate analyses. <h3>Results:</h3> We attempted AED withdrawal in 94 (88.7%) patients. Forty-four (41.5%) patients had seizure recurrence while reducing AED, of which 14 (31.8%) did not become seizure-free subsequently. On multivariate analysis, an abnormal postoperative EEG and longer preoperative duration of epilepsy predicted seizure recurrence, while early postoperative seizures and presence of gliosis or dysplasia were additional predictors on univariate analysis. At mean follow-up duration of 4.6 years, 63 (59.4%) patients were seizure-free. The cumulative probability of achieving complete AED-free status was 20% at fourth year, 34% at sixth year, 40% at eighth year, and 52% at 10th year after surgery. <h3>Conclusions:</h3> Following resective extratemporal epilepsy surgery, AED can be successfully discontinued in only in a minority of patients. One-third of patients who recur fail to regain seizure control upon AED reintroduction. Longer duration of epilepsy prior to surgery, abnormal postoperative EEG, early postoperative seizures, and focal gliosis or dysplasia as substrate predispose to seizure recurrence. This information will be helpful in making rational decisions on AED withdrawal following extratemporal resective epilepsy surgery.
Prevention and Early Treatment of Opportunistic Viral Infections in Patients With Leukemia and Allogeneic Stem Cell Transplantation Recipients
Authors: Michael Angarone, Michael G. Ison
Journal: Journal of the National Comprehensive Cancer Network (2008)

A leading complication of leukemia therapy and stem cell transplantation is opportunistic viral infections. Infections caused by cytomegalovirus, herpes simplex, varicella-zoster, Epstein-Barr, and the community respiratory viruses are associated with significant morbidity and mortality in this highly immunosuppressed population. Fortunately, a growing armamentarium is allowing more effective prophylaxis of these pathogens. This article reviews the epidemiology and prophylactic strategies available for these common opportunistic viral pathogens.
Hereditary Malformation of the Hands and Feet; with Operation on One Subject
Authors: W. R. Smith, J. S. Norwell
Journal: BMJ (1894)

trophied, and during life the veins in the neck would occa- si,onally stand out like tubes the thickness of one's little finger.The pulse at first was rather hard and incompressible, later on small and jerky, whilst towards the end of life it became very rapid and small, but never to any extent irregu- lar.Taken in conjunction with my remarks upon the dis- tended right chambers of the heart and the venous system generally, the two attacks of profuse epistaxis are worthy of notice.
Placebo Effects and Informed Consent
Authors: Mark Alfano
Journal: The American Journal of Bioethics (2015)

The concepts of placebos and placebo effects refer to extremely diverse phenomena. I recommend dissolving the concepts of placebos and placebo effects into loosely related groups of specific mechanisms, including (potentially among others) expectation-fulfillment, classical conditioning, and attentional-somatic feedback loops. If this approach is on the right track, it has three main implications for the ethics of informed consent. First, because of the expectation-fulfillment mechanism, the process of informing cannot be considered independently from the potential effects of treatment. Obtaining informed consent influences the effects of treatment. This provides support for the authorized concealment and authorized deception paradigms, and perhaps even for outright deceptive placebo use. Second, doctors may easily fail to consider the potential benefits of conditioning, leading them to misjudge the trade-off between beneficence and autonomy. Third, how attentional-somatic feedback loops play out depends not only on the content of the informing process but also on its framing. This suggests a role for libertarian paternalism in clinical practice.
Airway epithelial toll-like receptor expression in asthma and its relationship to disease severity
Authors: Laura Cottey, Nivenka Jayasekera, Hans-Michael Hiatchi, Ben Green, Chris Grainge, Peter Howarth
Journal: European Respiratory Journal (2011)

Asthma is classically considered a Th2 mediated disease. However severe, treatment-resistant disease is more heterogeneous and often associated with airway neutrophil recruitment. This could be due to altered airway bacterial colonisation. Bacteria express molecular patterns that are recognised as non-self by pattern recognition receptors expressed on innate cell surfaces such as Toll-like receptors (TLR9s). This study has investigated the expression of mRNA for TLR-2, -4 and -5 in airway epithelial cells in asthmatics and healthy volunteers.  Epithelial brushings were obtained from the large airways at bronchoscopy from 18 healthy non-asthmatic volunteers and 34 asthmatic volunteers. The asthmatic group comprised 7 non-steroid treated and 27 steroid treated asthmatics. RT-qPCR analysis was performed on extracted RNA for TLR-2,-4 and -5 and IL-8.  Gene expression for TLR-2 (p=0.008) and TLR-4 (p=0.012) was significantly increased within the asthmatic sample compared to healthy subjects whilst TLR5 expression did not differ significantly. IL-8 mRNA was also increased in the asthmatic population (p=0.007) compared to that of healthy subjects. These significant differences from the healthy population were also individually present in both the mild and severe asthmatics groups, with no significant difference being evident between mild and severe asthma.  These findings reveal up-regulation of epithelial gene expression for TLR family members and IL-8 relevant to bacterial responses within the airways. These features are indicative of ongoing innate immune airway responses in asthma. The relevance of this to clinical disease expression requires understanding.
Intrapleural streptokinase therapy in tubercular pleural effusions - Randomized controlled study
Authors: Gajanan Gaude, H. Sandeep, Jyothi Hattiholi
Journal: European Respiratory Journal (2013)

Background: Tuberculosis (TB) is the most common cause of exudative lymphocytic pleural effusion in India. Residual pleural thickening (RPT) is present in about 50% of patients even after the proper therapy for TB. The present study was done to evaluate the efficacy of intrapleural instillation of streptokinase in the TB pleural effusion and its influence on the incidence of RPT at the end of 1 year.  Materials and Methods: Clinical profiles, hospital course and outcome of TB pleural effusion patients at the end of 6 months of anti-TB therapy of 100 patients were analyzed. All the patients were diagnosed by combination of various modalities. These patients were randomly divided into two groups: study group (50) received intrapleural streptokinase via pigtail catheter and control group (50) received intercoastal drainage without streptokinase instillation. All patients received standard anti-TB therapy with 2HERZ/4HR and were followed up for 1 year for any evidence of RPT.  Results: Majority of patients were more than 40 years of age with mean ADA of 70IU/L. the mean pleural fluid drainage was 2616 ±126 ml in the study group and 1858 ±93 ml in the control group (p   Conclusion: Intrapleural streptokinase is successful in increasing the total drainage of pleural fluid and decreased incidence of RPT in TB pleural effusions.
Thymoma and thymic carcinoma: A retrospective analysis of the Brazilian National Cancer Institute (INCA) Experience.
Authors: C. S. Baldotto, M. Siqueira, J. Gonzaga, M. Zukin
Journal: Journal of Clinical Oncology (2010)

e12043 Background: Thymoma (T) and thymic carcinoma (TC) are exceptionally rare tumors. Most studies of thymic neoplasms are based on small numbers of clinical cases and an optimal treatment remains to be defined. The Brazilian National Cancer Institute (INCA) is a cancer reference center in Brazil, receiving patients from all over the country. The aim of this study was to investigate the clinicopathologic features, treatment modalities, and outcome of T and TC in our population, as a step in further understanding these uncommon neoplasms. Methods: A retrospective review of the medical records of patients who had a pathologic diagnosis of T or CT was performed between January 1996 and December 2007 at a single institution (INCA). Results: A total of 43 patients were included. The mean age at diagnosis was 57 (range: 26–78), and the male/female ratio was 2:3 (18/25). Masaoka stage distribution is presented in the Table. There was a predominance of WHO type A, B1, and AB. Paraneoplastic syndromes were detected in 20.4% of cases. For survival analysis patients were subdivided in initial disease (Masaoka I and II) and advanced disease (Masaoka III and IV). Complete resection was possible in 92.5% of patients with initial disease and 7 patients, all Masaoka stage II, received adjuvant radiotherapy. Only one patient had progressive disease and died. Sixteen (72.7%) patients with advanced disease were treated with a multimodality neoadjuvant approach. Surgical resection was possible in only 8 (50%) of these patients. Five-year survival and progression-free survival rates were estimated respectively in 31.8% and 39.9% for advanced disease. Conclusions: Clinical characteristics, treatment features, and survival rates were in line with previous reports from other countries. Our results, in a 12-year period, show a representative amount of cases, and the poor overall survival for advanced disease suggests the need for new strategies to improve outcomes. Masaoka stage distribution Masaoka stage Frequency (%) I 27.9 II 20.9 III 37.2 IVA 9.3 IVB 4.7 No significant financial relationships to disclose.
Assessment of Left Ventricular Dyssynchrony by Speckle Tracking Strain Imaging
Authors: Victoria Delgado, Claudia Ypenburg, Rutger J. van Bommel, Laurens F. Tops, Sjoerd A. Mollema, Nina Ajmone Marsan, Gabe B. Bleeker, Martin J. Schalij, Jeroen J. Bax
Journal: Journal of the American College of Cardiology (2008)
Impact of aerobic and resistance training of different intensities on peripheral muscle strength and BODE index in patients with COPD - Pilot study
Authors: Marina Sallum Barusso, Júlia Gianjoppe-Santos, Eloisa M.G. Regueiro, Jéssica C. Panin, Valéria A. Pires Di Lorenzo
Journal: European Respiratory Journal (2014)

Background:  The systemic effects of Chronic Obstructive Pulmonary Disease (COPD) cause reduction in the physical capacity and increase the mortality risk. The combined aerobic and resistence training is the most complete physiologically resource for improvement on peripheral muscle strength and functional capacity.  Aim:  To compare the effects of aerobic and resistance training in different intensities on peripheral muscle strength and BODE index in patients with COPD.  Methods:  Fifteen patients with moderate to very severe COPD were assessed pre and post both physical training by: six-minute walk test (6MWT), modified Medical Research Council (mMRC), peripheral muscle strength testing and BODE Index. The patients underwent a 36 training sessions were randomized into two groups: Aerobic + High Intensity Resistance Training (HI-RT, n=7, 67±6yrs; FEV 1  51±17%pred) and Aerobic+Low Intensity Resistance Training (LI-RT, n=8, 63±8yrs, FEV 1  44.8±17.6%pred).  Results:  There was a significant increase (p≤0.05) in the isometric knee extensors strength (KExt) (from 287±99N to 320±80N) and shoulder flexors (from 114±20N to 137±22N) for LI-RT and KExt (from 288±71N to 330±85N) and elbow flexors (from 134±31N to 154±38N) for HI-RT group. It was found a significant reduction in the BODE Index score (from 3±2 to 2±2) and an increase in 6MW distance (from 453±77m to 480±74m) only for the HI-RT group. No significant difference was detected for hip abductors in both groups.  Conclusion: Both groups rose the peripheral isometric strength, though the HI-RT seems to be more efficient to improve exercise tolerance and disease prognosis.
Second malignant neoplasms complicating Hodgkin's disease: the National Cancer Institute experience.
Authors: W J Tester, T J Kinsella, B Waller, R W Makuch, P A Kelley, E Glatstein, V T DeVita
Journal: Journal of Clinical Oncology (1984)

The medical records of all patients treated for Hodgkin's disease during the years 1964-1981 were reviewed. Four hundred seventy-three previously untreated patients were analyzed. Thirty-four subsequent second malignant neoplasms were observed in 33 patients among those treated for Hodgkin's disease. Eight cases of acute nonlymphocyctic leukemia, one case of chronic myeloid leukemia, three cases of non-Hodgkin's lymphoma, three cases of sarcoma, and 19 other tumors were identified. The ten-year estimated risk of leukemia by treatment was the following: radiotherapy only (0), chemotherapy only (0.02), initial combined radiotherapy-chemotherapy (0.06), and salvage combined radiotherapy-chemotherapy (0.09). The ten-year estimated risk of solid tumors was 0.07 overall, with all treatment groups associated with similar risks. Unlike some other reports, a greater risk of leukemia in patients who began treatment for Hodgkin's disease at age 40 or older was not found. However, a positive association was noted between increasing risk of solid tumors and increasing patient age.
Clinical Aspects of Meningeal Carcinomatosis
Authors: J. W. A. Swen, J. W. Hengefeld, L. J. Endtz
Journal: Neuro-Oncology (1980)

Although carcinomatous meningitis is a good descriptive term, the lesion is purely neoplastic and signs of meningitis are not always present. It therefore seems more appropriate to speak of meningeal carcinomatosis. This affection is a diffuse or widespread multifocal seeding of the leptomeninges of the brain and spinal cord by a metastatic tumour. Eberth (1) gave the first description of a patient with this clinical picture. Recent reports indicate that this complication of systemic cancer is a still increasing problem (2, 3). Because the blood-brain barrier prevents many anti-neoplastic drugs from reaching the central nervous system, it is extremely difficult to treat metastasis beyond this barrier.
β2 adrenoceptor polymorphisms (ADRB2 gene) are not strongly associated with asthma incidence or prevalence.
Authors: M Pagaria
Journal: Thorax (2007)

▴ Hall IP, Blakey JD, Al Balushi KA, et al . β2-adrenoceptor polymorphisms and asthma from childhood to middle age in the British 1958 birth cohort: a genetic association study. Lancet2006;368:771–79.

[OpenUrl][1][CrossRef][2][PubMed][3][Web of Science][4]



The aim of this study was to analyse any potential correlation between β2 adrenoceptor ( ADRB2 ) polymorphism and asthma risk and prognosis. The ADRB2 gene contains polymorphic variants with high minor allele frequencies in the white population. The three coding regions, Arg16Gly, Gln27Glu and Thr164Ile, are shown to be functionally relevant. Previous meta analyses looking into the correlation between the genetic polymorphism and asthma risk have …

 [1]: {openurl}?query=rft.jtitle%253DLancet%26rft.stitle%253DLancet%26rft.aulast%253DHall%26rft.auinit1%253DI.%2BP.%26rft.volume%253D368%26rft.issue%253D9537%26rft.spage%253D771%26rft.epage%253D779%26rft.atitle%253DBeta2-adrenoceptor%2Bpolymorphisms%2Band%2Basthma%2Bfrom%2Bchildhood%2Bto%2Bmiddle%2Bage%2Bin%2Bthe%2BBritish%2B1958%2Bbirth%2Bcohort%253A%2Ba%2Bgenetic%2Bassociation%2Bstudy.%26rft_id%253Dinfo%253Adoi%252F10.1016%252FS0140-6736%252806%252969287-8%26rft_id%253Dinfo%253Apmid%252F16935688%26rft.genre%253Darticle%26rft_val_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Ajournal%26ctx_ver%253DZ39.88-2004%26url_ver%253DZ39.88-2004%26url_ctx_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Actx
 [2]: /lookup/external-ref?access_num=10.1016/S0140-6736(06)69287-8&link_type=DOI
 [3]: /lookup/external-ref?access_num=16935688&link_type=MED&atom=%2Fthoraxjnl%2F62%2F1%2F28.atom
 [4]: /lookup/external-ref?access_num=000240240200029&link_type=ISI
The incidence of alpha-1-antitrypsin (A1AT) deficiency alleles in Polish population - Results from the ongoing newborn screening
Authors: Joanna Chorostowska-Wynimko, Radoslaw Struniawski, Beata Poplawska, Maria Borszewska-Kornacka
Journal: European Respiratory Journal (2013)

Data concerning the prevalence of A1AT deficiency in Poland are very limited due either to small groups analyzed or unreliable methodology. Here, we present the up-date from the large scale newborn screening ongoing in Central Poland.  Methods: DBS samples were collected prospectively from 2423 newborns between September 2011 – December 2012. AAT serum concentration was measured by nephelometry and PI-phenotype identified by real-time PCR. The PI*S and PI*Z alleles were confirmed by isoelectrofocusing.  Results: Deficiency S- or Z allele was observed respectively in 54 (2,23%) and 55 (2,27%) DBS samples (in total 109 (4,5%) samples). Calculated frequencies expressed per 1000 were for PI*Z 11,3 (95% CI: 8,4-14,3), PI*S 11,1 (95% CI: 8,2-14,1). The AAT gene prevalence calculated by Hardy-Weinberg equilibrium were: 1/1.04 for MM, 1/46 for MS, 1/8053 for SS, 1/45 for MZ, 1/3953 for SZ and 1/7763 for ZZ. The mean A1AT concentration was 177±39 mg/dl, in non-S non-Z individuals 179±38 mg/dl, in PI*S carriers 154±36 mg/dl, in PI*Z 116±17 mg/dl.  Conclusion: Our results suggest considerably higher prevalence of deficiency alleles in Polish population than currently available data.
European Perspectives
Authors: Stanley Heptinstall, Christian Spaulding, Jan Danser, Sigrun Halvorsen, Stefan James, Jaakko Tuomilehto, Stefan Hohnloser, Thierry Lefèvre, Peter Carmeliet, Adriana Gittenberger-de Groot
Journal: Circulation (2010)

and meant that the textbooks on the diagnosis, risk stratification, and treatment algorithms of acute coronary syndrome had to be rewritten.
Metabolic Adaptation To Tissue Iron Overload Confers Tolerance To Malaria
Authors: Raffaella Gozzelino, Bruno Bezerril Andrade, Rasmus Larsen, Nivea F. Luz, Liviu Vanoaica, Antonio Coutinho, Silvia Cardoso, Sofia Rebelo, Maura Poli, Manoel Barral-Netto, Deepak Darshan, Lukas Kuehn, Miguel P. Soares
Journal: American Journal of Hematology (2013)

Reference EPFL-CONF-189179View record in Web of Science Record created on 2013-10-01, modified on 2017-05-12