RENAL FUNCTION DURING PREGNANCY COMPLICATED BY INTERCAPILLARY GLOMERULOSCLEROSIS: SERIAL STUDIES IN A YOUNG DIABETIC
Authors: E A SIMS
Journal: Annals of Internal Medicine (1960)

Case Reports1 March 1960RENAL FUNCTION DURING PREGNANCY COMPLICATED BY INTERCAPILLARY GLOMERULOSCLEROSIS: SERIAL STUDIES IN A YOUNG DIABETICETHAN A. H. SIMS, M.D., F.A.C.P.ETHAN A. H. SIMS, M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-52-3-693 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptINTRODUCTIONRecent studies of renal function in normal pregnancy have indicated that the renal plasma flow and glomerular filtration rate are increased roughly 50 and 30% respectively, particularly during midpregnancy.1, 2It is known that diabetic patients may enter pregnancy with renal function impaired as a result of intercapillary glomerulosclerosis (Kimmelstiel-Wilson syndrome), but may nevertheless successfully complete pregnancy without further deterioration of renal function, although in general the presence of nephritis places the patient in a relatively poor prognostic category.3However, little is known about the course of pregnancy with respect to renal function in these patients and how it...Bibliography1. Bucht H: Studies on renal function in man with special reference to glomerular filtration and renal plasma flow in pregnancy, Scandinav. J. Clin. and Lab. Invest. 3 (Suppl. 3): 1, 1951. MedlineGoogle Scholar2. SimsKrantz EAKE: Serial studies of renal function during pregnancy and the Puerperium in normal women, J. Clin. Investigation 37: 1764, 1958. CrossrefMedlineGoogle Scholar3. NelsonGillespieWhite HBLP: Pregnancy complicated by diabetes mellitus, Obst. and Gynec. 1: 219, 1953. Google Scholar4. WelshSims GWEA: Unpublished studies. Google Scholar5. BaldwinSchreinerBreedWessonMaxwell DSGEESLGMH: Depression of apparent p-aminohippurate extraction ratio by glucose, J. Clin. Investigation 29: 614, 1950. CrossrefMedlineGoogle Scholar6. BuchtEkWerkö HJL: Renal function studies in diabetic nephropathy, Scandinav. J. Clin. and Lab. Invest. 8: 309, 1956. CrossrefMedlineGoogle Scholar7. Gradwohl R: Clinical laboratory methods, 4th Ed., 1948, Vol 1, the C. V. Mosby Company, St. Louis, p. 67. 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WelshSims GWEA: Renal tubular reabsorption of glucose and the mechanism of glycosuria in pregnancy, Clin. Res. 6: 287, 1958 (Abstract). Google Scholar15. Friedenwald JS: New approach to some problems of retinal vascular disease, Am. J. Ophth. 32: 487, 1949. CrossrefMedlineGoogle Scholar16. LeCompte PM: Vascular lesions in diabetes mellitus, J. Chron. Dis. 2: 178, 1955. CrossrefMedlineGoogle Scholar17. BerkmanRifkinRoss JHG: The serum polysaccharides in diabetic patients with and without degenerative vascular disease, J. Clin. Investigation 32: 415, 1953. CrossrefMedlineGoogle Scholar18. KinsellLawrenceBalchWeyand LWLHERD: Hypophysectomy in human diabetes: metabolic and clinical observations in diabetics with malignant vascular disease, Diabetes 3: 358, 1954. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Burlington, Vermont*Received for publication July 20, 1959.Presented at the Fortieth Annual Session of The American College of Physicians, Chicago, Illinois, April 21, 1959.From the Department of Medicine, College of Medicine, University of Vermont, Burlington, Vermont.This study was supported through a grant, RG-3745, from the U. S. Public Health Service, National Institutes of Health.Requests for reprints should be addressed to Ethan A. H. Sims, M.D., Department of Medicine, Medical Alumni Building, The University of Vermont College of Medicine, Burlington, Vermont. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byMedical Aspects of Diabetes in Pregnancy and the Diabetogenic Effects of Oral ContraceptivesControlling the Kidney in PregnancyDie Nephropathien in der SchwangerschaftChronic renal diseases and pregnancy: A reviewChronic renal disease and pregnancyErkrankungen der inneren Organe Krankheiten des Herzens und der GefäßeTHE NEPHROTIC SYNDROME IN PREGNANCY 1 March 1960Volume 52, Issue 3Page: 693-702KeywordsBlood plasmaGlomerular filtration rateHypertensionMedical servicesNephritisPregnancyProteinuriaRegenerative medicine Issue Published: 1 March 1960 PDF downloadLoading ...