tbuckley/cabot-search huggingface dataset:
A new scale for the assessment of depressed mood in demented patients
Authors: T Sunderland, I S Alterman, D Yount, J L Hill, P N Tariot, P A Newhouse, E A Mueller, A M Mellow, R M Cohen
Journal: American Journal of Psychiatry (1988)

Twenty-one subjects with clinically diagnosed dementia of the Alzheimer type were rated on the Dementia Mood Assessment Scale, a new instrument intended to measure the severity of depressed mood in cognitively impaired patients. Ratings were based on direct observation and a semistructured interview of the patient. Interrater reliability was established. There were highly significant correlations between patients' scores on the instrument's 17-item depression subscale and their scores on global measures of depression and sadness. The potential usefulness of this new scale in assessing the severity of depression in demented patients longitudinally or under drug treatment conditions is discussed.
Outbreak due to a Klebsiella pneumoniae strain harbouring KPC-2 and VIM-1 in a German university hospital, July 2010 to January 2011
Authors: J Steinmann, M Kaase, S Gatermann, W Popp, E Steinmann, M Damman, A Paul, F Saner, J Buer, P M Rath
Journal: Eurosurveillance (2011)

We describe the epidemiology and characteristics of the pathogen and patients (n=7) associated with an outbreak of a carbapenem-resistant Klebsiella pneumoniae (CRKP) strain in a German university hospital from July 2010 to January 2011. Species identification and detection of carbapenem resistance were carried out using standard microbiological procedures. Carbapenemases were detected by phenotypic methods and specific polymerase chain reactions (PCRs). DNA fingerprinting profiles were performed with repetitive sequence-based PCR. Medical records of colonised or infected patients were retrospectively reviewed. Antibiotic resistance profiles, PCR-specific amplification products and genotyping demonstrated that the outbreak occurred because of the spread of a single CRKP clone harbouring both KPC-2 and VIM-1. Five of the seven patients had invasive infections with the CRKP strain; the deaths of four of them were directly related to the infection. Early implementation of infection control interventions brought about efficient containment of further cross-transmission. Rapid dissemination of carbapenemase-producing Enterobacteriaceae is a serious concern in patient care and is a problem that has emerged in western Europe.
Abstract 8300: SkM1 Gene Transfer Into Canine Ventricular Myocardium Decreases the Threshold Potential for Action Potential Initiation
Authors: Eugene A Sosunov, Gerard J Boink, Iryna N Shlapakova, Yelena Kryukova, Peter Danilo, Evgeny P Anyukhovsky, Ira S Cohen, Richard B Robinson, Michael R Rosen
Journal: Circulation (2011)

Introduction: We have previously shown that combined HCN2/SkM1 gene expression in canine left bundle branch (LBB) results in a biological pacemaker having a faster rate than that based on HCN2 alone. We now tested the hypothesis that expressing Nav1.4 channels (encoded by the SkM1 gene) decreases the threshold potential (TrP) for action potential (AP) initiation. Thus, in the LBB expressing Nav1.4, the same slope of phase 4 depolarization should bring membrane potential to TrP faster, resulting in a more rapid automatic rate. We now tested this hypothesis in left ventricular subepicardial (LV) preparations suitable for current injection and TrP measurement. Methods: Adenoviral constructs of HCN2, SkM1 or HCN2/SkM1 were implanted into canine anterior LV. At 7d, myocardial fascicles (~0.5 mm diameter, 6-10 mm long) were isolated from injected sites and transferred to a tissue bath having 2 compartments separated by a plastic membrane with a hole permitting passage of the preparation. Transmembrane potential was recorded by microelectrodes. Preparations were driven at 1 Hz and every 10th stimulus was substituted by a 30 ms pulse of extracellular depolarizing current. The magnitude of depolarizing current was gradually increased until AP was initiated and TrP recorded. Results: For regularly paced AP, there were no differences in maximum diastolic potential (MDP) among groups whereas maximum upstroke velocity (V max ) was higher in SkM1 and HCN2/SkM1 than in HCN2 (Table, * P &lt;0.05 vs HCN2). TrP was significantly more negative and V max at TrP was higher in SkM1 and HCN2/SkM1 than in HCN2 (Table, * P &lt;0.05 vs HCN2). Conclusions: Expression of Nav1.4 Na+ channels can accelerate the rate of HCN2 based biological pacemakers by decreasing TrP for AP initiation.
Sensory input deficits and negative symptoms in schizophrenic patients
Authors: D L Braff
Journal: American Journal of Psychiatry (1989)

The information-processing correlates of positive and negative symptoms in schizophrenic patients are of increasing clinical research interest. The author tested 40 schizophrenic patients and 35 normal control subjects and reports on two major findings. First, patients with negative symptoms had dramatic inflations of stimulus recognition thresholds, similar to the deficits previously reported in patients with head injuries resulting in organic brain syndromes. Second, the schizophrenic patients had deficits in the time-dependent processing of information. Collectively, these data support the link between negative symptoms and multiple levels of information-processing abnormalities in patients with schizophrenic disorders.
Abstract 15602: Rotors and Focal Sources Frequently Localize Outside Anatomically-Based Ablation Sites
Authors: David E Krummen, Carey R Briggs, Ruchir Sehra, Wouter-Jan Rappel, Sanjiv M Narayan
Journal: Circulation (2011)

Introduction: Prior elegant animal studies have shown atrial fibrillation electrical rotors and focal sources may exist outside pulmonary veins (PVs). We therefore hypothesized that computational a...
In Vivo Proof of Concept of Activity and Safety of UCART19, an Allogeneic “Off-the-Shelf” Adoptive T-Cell Immunotherapy Against CD19+ B-Cell Leukemias
Authors: Agnes Gouble, Brian Philip, Laurent Poirot, Cecile Schiffer-Mannioui, Roman Galetto, Sophie Derniame, Gordon Weng-Kit Cheung, Sylvain Arnould, Carole Desseaux, Martin Pule, Julianne Smith
Journal: Blood (2014)
Multicenter Intravascular Ultrasound Validation Study Among Heart Transplant Recipients
Authors: Jon A. Kobashigawa, Jonathan M. Tobis, Randall C. Starling, E. Murat Tuzcu, Andrew L. Smith, Hannah A. Valantine, Alan C. Yeung, Mandeep R. Mehra, Hitoshi Anzai, Brandy T. Oeser, Kamal H. Abeywickrama, Jane Murphy, Nathalie Cretin
Journal: Journal of the American College of Cardiology (2005)
Abstract 1380: Role of Copper Transport System for Extracellular Superoxide Dismutase in Angiotensin II-Induced Hypertension
Authors: Kiyoshi Ozumi, Ha Won Kim, Ronald D McKinney, Masuko Ushio-Fukai, Tohru Fukai
Journal: Circulation (2008)

Extracellular superoxide dismutase (ecSOD) is a secretory copper enzyme highly expressed in the vasculature, and plays an important role in protecting angiotensin II (Ang II)-induced hypertension by reducing the extracellular levels of vascular superoxide. Copper-containing enzymes obtain cofactor copper through specific copper transport system including the copper uptake transporter Ctr1 and the copper chaperone/transcription factor, antioxidant-1 (Atox1). We previously demonstrated that Ang II upregulates ecSOD expression and activity; however, underlying molecular mechanisms remain unclear. Here we show that ecSOD expression and activity are markedly decreased in fibroblasts lacking Atox1 or Ctr1. Western and immunohistochemical analysis reveal that chronic Ang II infusion (500 ng/kg/min) for 7 days increases nuclear staining of Atox1 and ecSOD protein expression in mouse aorta, which are abolished in Atox1−/− mice. In cultured vascular smooth muscle cells, Ang II stimulates translocation of Atox1 from cytosol to nucleus with peak at 30 min, which is prevented in Ctr1−/− cells. Luciferase reporter gene assays show that Ang II increases ecSOD promoter by 4.1±0.2 fold, which is blocked by the mutation of Atox1 responsive elements (Atox1-RE) and by siRNA knockdown of Ctr1. DNA pull down assays show that Ang II markedly increases binding of Atox1 to the Atox1-RE including DNA segment in the ecSOD promoter. Of note, Atox1 co-immunoprecipitates with Ctr1 in a copper dependent manner. These findings suggest that Atox1 functions as a transcription factor for ecSOD in a Ctr1-dependent manner. Finally, Ang II infusion-induced increase in systolic blood pressure and vascular superoxide production, as measured by lucigenin assay, are further enhanced in Atox1−/− mice compared to those in WT mice (149±2.3 (KO) vs. 137±1.2 (WT) mmHg; 4.0±0.2 (KO) vs. 2.54±0.2 (WT) fold), both of which are reduced by treatment of the SOD mimetic tempol. In summary, copper-dependent transcription factor function of Atox1 plays an important role in Ang II-induced upregulation of ecSOD expression and activity through Ctr1-Atox1 pathway, which may contribute to preventing oxidant-stress-dependent Ang II-induced hypertension.
Graft versus host disease prophylaxis with low-dose cyclosporine-A reduces the risk of relapse in children with acute leukemia given HLA-identical sibling bone marrow transplantation: results of a randomized trial
Authors: Franco Locatelli, Marco Zecca, Roberto Rondelli, Federico Bonetti, Giorgio Dini, Arcangelo Prete, Chiara Messina, Cornelio Uderzo, Mimmo Ripaldi, Fulvio Porta, Giovanna Giorgiani, Eugenia Giraldi, Andrea Pession
Journal: Blood (2000)
Deaf or Dead?
Authors: C. W. H. Havard, L. P. Garrod, P. M. Waterworth
Journal: BMJ (1959)

The following is the history of a patient who had to be warned that the treatment necessary to save his life would probably cause severe deafness.He accepted this consequence.and suffered it, but he is alive and well nearly a year later.The history also illustrates the value of tests of combined antibiotic bactericidal action in difficult cases of bacterial endocarditis.
A phase I study of amrubicin and carboplatin for previously untreated patients with extensive stage small-cell lung cancer
Authors: M. Fukuda, Y. Nakamura, T. Kasai, A. Kinoshita, M. Fukuda, K. Motoshima, T. IIda, K. Nakatomi, H. Soda, M. Oka, S. Kohno
Journal: Journal of Clinical Oncology (2008)

19070 Background: Amrubicin (AMR) and cisplatin are active in the treatment of small cell lung cancer (SCLC), and carboplatin (CBDCA) is an analogue of cisplatin with less nonhematological toxicity. However, the appropriate dose of AMR and CBDCA combination chemotherapy for previously untreated patients with extensive stage SCLC has not been established. This phase I trial aimed to determine the maximum tolerated dose (MTD) and the dose-limiting toxicity (DLT). Methods: Eligibility criteria were chemotherapy-naïve extensive stage SCLC patients (pts), performance status (PS) 0–1, age ≤ 75, and adequate hematological, hepatic and renal function. Pts received escalating AMR dose under a fixed target AUC = 5 of CBDCA (Chatelut formula, Jaffe method). AMR and CBDCA were administered i.v. infusion on days 1, 2 and 3, and day 1. The initial dose of AMR was 30 mg/m2, and the dose was escalated to 35 and 40. DLT was defined as grade (G) 4 leukopenia (L) or neutropenia (N) lasting ≥ 4 days, G4 thrombocytopenia (T), febrile neutropenia or non-hematologic toxicity ≥ G3. Therapy was repeated in every 4 weeks. Results: 16 pts were enrolled and 15 eligible pts were evaluated. Pts’ characteristics: male/female = 15/0; PS 0/1 = 2/13; median age (range) = 67 (49–75); IIIB/IV = 6/9. Toxicities were in Table. One of 6 pts in level 1, 1 of 6 in level 2, and 3 of 3 in level 3 experienced DLT. Evaluation of responses were: 2CR, 9PR, 3SD and 1PD (RR 73%). Conclusions: The MTD dose of AMR and CBDCA were determined 40 mg/m2 and AUC=5. The DLT were neutropenia, thrombocytopenia, leucopenia, febrile neutropenia, and liver dysfunction. The dose of AMR 35 mg/m2 and CBDCA AUC = 5 was recommended in this study. Toxicities Level Amrubicin Carboplatin Pts G3/4L G3/4N G3/4T Liver ≥ 3 DLT 1 30 AUC=5 6 1/1 4/1 1/0 1 1 2 35 AUC=5 6 2/0 4/2 2/1 0 1 3 40 AUC=5 3 1/2 0/3 1/1 0 3 No significant financial relationships to disclose.
Abstract 4625: Dantrolene Inhibits Spontaneous Ca <sup>2+</sup> Release as a Substrate for Catecholaminergic Polymorphic Ventricular Tachycardia (PSVT) by Correcting Defective Inter-Domain Interaction within the Ryanodine Receptor
Authors: Shigeki Kobayashi, Masafumi Yano, Takeshi Suetomi, Makoto Ono, Xiaojuan Xu, Hitoshi Uchinoumi, Hiroki Tateishi, Shinichi Okuda, Takeshi Yamamoto, Masunori Matsuzaki
Journal: Circulation (2008)

We previously reported that dantrolene, a therapeutic agent for malignant hyperthermia (MH), prevented abnormal Ca 2+ leak by correction of the defective inter-domain interaction between N-terminal (1– 600) and central (2000 –2500) domains in MH-type ryanodine receptor (RyR). These N-terminal and central domains of the RyR, harbor many mutations associated with MH in RyR1 and CPVT in RyR2. Here, we examined the effect of dantrolene on the Ca 2+ release in CPVT-associated RyR2 R2474S/ + knock-in (KI) mice model. In KI (but not in wild-type:WT) mice (n=6), ventricular tachycardia was observed during or after exercise with treadmill (6/6), which was prevented by pretreatment of dantrolene (20 mg −1 kg −1 day −1 , for 7 days). Cardiac sarcoplasmic reticulum (SR) vesicles were isolated (n=4), then RyR2 was fluorescently labeled with methylcoumarin acetamido (MCA) using DP 2460 – 2495 (DPc10), harboring the CPVT mutation site; R2474S, as a site-directing carrier. Only in KI (but not WT) SR, cAMP (1 μM) reduced stabilizing interactions between N-terminal and central domains (viz. domain unzipping), as assessed by the quenching of the MCA fluorescence by a large-size fluorescence quencher. Dantrolene (1 μM) inhibited the cAMP-induced domain unzipping (in KI) without effect on the cAMP-induced increase in Ser2808 phosphorylation that showed no difference between WT and KI. Using a quartz crystal microbalance technique (a highly sensitive mass-measuring technique), dantrolene was found to specifically bind to the domain 601– 620 of RyR2. In isolated, saponin-permeabilized cardiomyocytes, local Ca 2+ release events were measured using a confocal microscopy with Rhod-2; [Ca 2+ ] was buffered at 30 nM by 0.5 mM EGTA. In KI, the frequency of Ca 2+ sparks (SpF: s −1 · 100 μm −1 ) was much more increased in response to 1μM cAMP (9.7±0.4 in WT; 14.5±0.4 in KI, p&lt;0.01). In the co-presence of dantrolene (1 μM), the increase in SpF in KI was markedly inhibited. In conclusion, dantrolene, by normally restoring the defective inter-domain interaction, seems to correct the hyper-activated channel gating caused by RyR2 mutation, thereby inhibiting spontaneous Ca 2+ release leading to lethal arrhythmia.
Abstract 3478: Midregional Pro-Adrenomedullin (MR-proADM) in a Cardiovascular Risk Population- Impact on Diastolic Dysfunction
Authors: Frank Edelmann, Ingmar Rahn, Rolf Wachter, Gotz Gelbrich, Anke Kockskamper, Jan Kunde, Gerd Hasenfuss, Burkert M Pieske
Journal: Circulation (2009)
Abstract 13260: Glial Fibrillary Acidic Protein in Children With Congenital Heart Disease Undergoing Cardiopulmonary Bypass
Authors: Marissa A Brunetti, R. B Easley, Melania Bembea, Anna Brown, Eugenie Heitmiller, Jamie M Schwartz, Jacky M Jennings, Ken M Brady, Allen D Everett
Journal: Circulation (2011)
Abstract 10076: Angiotensin II Downregulates Micro-RNA 22 to Promote CYR61-Mediated Vascular Smooth Muscle Cell Calcification
Authors: Hae-Young Lee, Joshua A Balderman, Hyun-Joo Cho, Yeon-Yee Yoon, Hyo-Soo Kim, Joseph Loscalzo, Jane A Leopold
Journal: Circulation (2011)

Angiotensin II (AngII) has been linked to vascular calcification; however, the molecular mechanism(s) by which this occurs remain unknown. We hypothesized that AngII increases vascular smooth muscle cell (SMC) calcification by regulating microRNAs (miR) to increase the expression of cysteine-rich angiogenic protein 61 (CYR61), which induces osteoblastic differentiation of mesenchymal stem cells. We treated human coronary artery SMC with AngII (10 -9  mol/l) and confirmed a 21.6-fold increase in CYR61 mRNA at 1 h (p
Effects of Ionizing Radiations on a Transplanted Lymphosarcoma&lt;xref ref-type="fn" rid="fn1"&gt;&lt;sup&gt;2&lt;/sup&gt;&lt;/xref&gt;
Authors: Joanne Hollcroft, Egon Lorenz, Harriet Hunstiger
Journal: JNCI Journal of the National Cancer Institute (1950)

Journal Article Effects of Ionizing Radiations on a Transplanted Lymphosarcoma Get access Joanne Hollcroft, Joanne Hollcroft Search for other works by this author on: Oxford Academic PubMed Google Scholar Egon Lorenz, Egon Lorenz Search for other works by this author on: Oxford Academic PubMed Google Scholar Harriet Hunstiger Harriet Hunstiger National Cancer Institute, National Institutes of Health, U. S. Public Health Service, Bethesda, Md., and Argonne National Laboratory, Chicago, Ill. Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 11, Issue 1, August 1950, Pages 1–16, https://doi.org/10.1093/jnci/11.1.1 Published: 01 August 1950 Article history Received: 03 March 1950 Published: 01 August 1950
Multimedia: Elsie Inglis
Authors: Melinda Tenant-Flowers
Journal: BMJ (1999)

Leah Leneman


NMS Publishing, £5.99, pp 94 




ISBN 1 901663 09 4

———————

Rating: ★★

“My good lady, go home and sit still,” was the rebuff issued to Dr Elsie Inglis, licentiate of the Royal Colleges of Glasgow and Edinburgh, with 16 years of hospital experience behind her, when she offered her services to the Royal Army Medical Corps at the outbreak of the first world war. As this biography points out, “there was nothing personal in this, men considered war to be their business, not that of the ‘weaker’ sex.” In 1916, “when the shortage of male doctors was so acute that medical women had to be recruited, they were kept well away from the front line and were never granted officer status.” The Scottish Women’s Hospitals for Foreign Service, however, led by Dr Inglis, was one example, running field hospitals and dressing stations in France, Serbia, Turkey, and Russia.

Elsie Inglis was born in India in 1864, trained in Edinburgh, and then worked in obstetrics and gynaecology. She was inspired by patriotism and the need to show that medical women did not have to be restricted to gynaecology and paediatrics. Her committee raised money, and the first hospital was set up in Paris in 1914. Their duties involved operating on and caring for the wounded, infection control, and arranging clean water and sewage control. The book describes the courage shown by Dr Inglis in the face of intimidation and accusations of spying. Her efforts were often not supported and sometimes obstructed by the British War Office, but the efforts of her team in maintaining high standards of asepsis and surgery in appalling conditions were recognised.

Compared with the body of literature concerning Florence Nightingale and other pioneering nurses, little has been written about the role of women doctors in the first world war. “To remember and to teach children about the achievements of Dr Elsie Inglis and the Scottish Women’s Hospitals would have been to acknowledge that medical women were every bit as capable as men.”
Abstract 10024: Fixative-free Decellularization of Human Pericardium Ensures Maintenance of Biomechanical Properties and Maximizes Graft Immunotolerance After Cryopreservation
Authors: Maria Cristina Vinci, Giulio Tessitore, Laura Castiglioni, Monica Soncini, Filippo Consolo, Barbara Micheli, Francesca Prandi, Rosaria Santoro, Luigi Sironi, Gianluca Polvani, Maurizio Pesce
Journal: Circulation (2012)
Stem cell transplantation in severe congenital neutropenia: an analysis from the European Society for Blood and Marrow Transplantation
Authors: Francesca Fioredda, Simona Iacobelli, Anja van Biezen, Bobby Gaspar, Phil Ancliff, Jean Donadieu, Mahmoud Aljurf, Christina Peters, Michaela Calvillo, Susanne Matthes-Martin, Giuseppe Morreale, Nelleke van ’t Veer-Tazelaar, Liesbeth de Wreede, Amal Al Seraihy, Akif Yesilipek, Alain Fischer, Marc Bierings, Gulyuz Ozturk, Owen Smith, Paul Veys, Per Ljungman, Régis Peffault de Latour, José Sánchez de Toledo Codina, Reuven Or, Arnold Ganser, Boris Afanasyev, Robert Wynn, Krzysztof Kalwak, Judith Marsh, Carlo Dufour
Journal: Blood (2015)
Drug points: Agranulocytosis associated with lamotrigine
Authors: O. A K. de Camargo, H. Bode
Journal: BMJ (1999)

To our knowledge, only leucopenia and thrombocytopenia have been described as possible haematological side effects of lamotrigine.1–3 We report a case of agranulocytosis associated with lamotrigine treatment.

A white girl aged 11 years 10 months who had left renal agenesis, an imperforate anus (corrected postnatally), neuronal heterotopia at the left insula, and seizures had been free of seizures for nearly two years while taking carbamazepine. …
Abstract 1158: Nox4 Mediates Cardiomyopathy Phenotype in Diabetes
Authors: Rita Maalouf, Assaad A Eid, Yves Gorin, Patricia Escobar, Mauli Agrawal, Hanna Abboud, Steven Bailey
Journal: Circulation (2009)

Cardiomyopathy is a common complication of type 1 and type 2 diabetes. Diabetic cardiomyopathy is characterized by myocyte hypertrophy, interstitial fibrosis and impaired left ventricular function....
Abstract 4347: Comparison of Dyssynchrony in Heart Failure Patients with Narrow QRS to Those with Wide QRS: Implications for Resynchronization Therapy
Authors: Han-Na Kim, HIdeyuki Hara, Hidekazu Tanaka, Olusequn Oyenuga, David Schwartzman, John Gorcsan
Journal: Circulation (2008)

Background Although cardiac resynchronization therapy (CRT) has been clearly shown to benefit patients with wide QRS, its use for patients with narrow QRS is currently unclear. Our objective was to test the hypothesis that there are significant differences in the prevalence and severity of dyssynchrony in heart failure patients with narrow QRS compared to wide QRS.

Methods We studied 310 class III-IV heart failure (HF) patients with ejection fraction ≤35% referred for CRT and/or implantable cardioverter defibrillator; 168 had QRS ≥120 ms and 142 had QRS <120 ms. Overall, 59% had ischemic disease. Dyssynchrony was assessed by tissue Doppler longitudinal velocity opposing wall delay (OWD), speckle tracking radial strain, pulsed Doppler interventricular mechanical delay (IVMD) and pre-ejection delay (PED).

Results Overall, the prevalence of interventricular dyssynchrony (IVMD> 40 ms) was significantly less (5%) in narrow QRS patients compared with 38% in wide QRS patients (p<0.001). Global dyssynchrony by IVMD and PED significantly correlated with QRS width (r=0.54 and r=0.58, p<0.001). The degree of radial dyssynchrony was also significantly less in the narrow QRS patients:118±93 versus 204±118 ms in the wide QRS patients (p<0.001). Interestingly, TDI opposing wall delay was not significantly different in narrow vs wide QRS groups.

Conclusions Narrow QRS HF patients have significantly less prevalent and less severe interventricular and intraventricular radial dyssynchrony, compared with those with wide QRS. However, TDI measures were similar in both groups. These findings may impact future CRT considerations.



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A Zebrafish Model Of Antithrombin III Deficiency Displays Bleeding and Thrombosis Secondary To Disseminated Intravascular Coagulation
Authors: Yang Liu, Colin A. Kretz, Morgan L. Maeder, Michael C. Huarng, Catherine E. Richter, Andy H. Vo, Philip Tsao, Alok Swaroop, J. Keith Joung, Jordan A. Shavit
Journal: Blood (2013)