THE PATHOLOGY AND MECHANISM OF ANAPHYLAXIS
Authors: Virgil H. Moon
Journal: Annals of Internal Medicine (1938)

Article1 August 1938THE PATHOLOGY AND MECHANISM OF ANAPHYLAXISVIRGIL H. MOONVIRGIL H. MOONSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-12-2-205 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptA survey of recorded studies on anaphylaxis and on shock reveals the remarkable fact that neither of these conditions has been investigated by the methods of pathology. Probably this was because this type of circulatory phenomenon was interpreted as a functional disturbance having no morphologic basis. The belief that postmortem examinations in such conditions reveal no significant changes, apparently had not been questioned.It has become apparent recently that a combination of the methods of pathology with those of physiology may produce pertinent evidence. It has been shown17a, b, 18that shock, occurring clinically or produced experimentally in various ways...Bibliography1. BOUGHTON TH: Anaphylactic death in asthmatics, Jr. Am. Med. Assoc., 1919, lxxiii, 1912. CrossrefGoogle Scholar2. BULLOWAJACOBI JGM: Fatal human anaphylactic shock; report of case with autopsy, observations and review of literature, Arch. Int. Med., 1930, xlvi, 306-315. CrossrefGoogle Scholar3. COCA AF: Die Ursache des plötzlicken Todes bei intravenöser Injektionen artfremder Blutkorper, Virchow's Arch., 1909, cxcvi, 92. CrossrefGoogle Scholar4. DALE HH: The anaphylactic reaction of plain muscle in the guinea pig, Jr. Pharm. and Exper. Therap., 1912, iv, 167. Google Scholar5. DEANWEBB HRRA: Blood changes in anaphylactic shock in dog, Jr. Path. and Bacteriol., 1924, xxvii, 65-79. CrossrefGoogle Scholar6. FIELDDRINKER MWCK: Permeability of capillaries of dog to protein, Am. Jr. Physiol., 1931, xcvii, 40-51. CrossrefGoogle Scholar7. FRIEDMANNFRÄNKEL UE: Ueber Veranderungen der Wasser- und Kochsalz ausscheidung während der Serumkrankheit, Verhandl. d. deutsch. Gesellsch. f. inn. Med., 1921, xxxiii, 400. Google Scholar8. GAYSOUTHARD FPEE: Further studies in anaphylaxis, Jr. Med. Res., 1907, xvi, 143; 1908, xix, 17. Google Scholar9. GUREWITSCH NA: Über den reflektorischen und den toxischen Gefässshock, Arch. f. clin. Chir., 1931, clxvi, 401-411. Google Scholar10. JOBLINGPETERSENEGGSTEIN JWWFAA: The mechanism of anaphylactic shock, Jr. Exper. Med., 1915, xxii, 401. CrossrefGoogle Scholar11. KARSNER HT: The lungs of the guinea pig in anaphylaxis produced by toxic sera, Immunitätsforsch. u. exper. Therap., 1912, xiv, 81. Bacteriology and immunology, 1928, chapter lxxiii, Jordan and Falk, University of Chicago Press. Google Scholar12. LAMSON RW: Sudden death associated with injection of foreign substances, Jr. Am. Med. Assoc., 1924, xcii, 1091-1098. CrossrefGoogle Scholar13. LEWIS T: Blood vessels of the human skin and their responses, 1927, Shaw and Sons, London. Google Scholar14. MACKENZIEHANGER GMFM: Serum disease and serum accidents, Jr. Am. Med. Assoc., 1930, xciv, 260. CrossrefGoogle Scholar15. MAJOR RH: Studies of blood chemistry in allergy, Bull. Johns Hopkins Hosp., 1923, xxxiv, 104-108. Google Scholar16. MANWARINGCHILCOTEHOSEPIAN WHRCVM: Capillary permeability in anaphylaxis, Jr. Am. Med. Assoc., 1923, lxxx, 303-309. CrossrefGoogle Scholar17. MOON VH: (1) The shock syndrome in medicine and surgery. (2) Shock, a definition and differentiation. (3) Mechanism of acute inflammation, ANN. INT. MED., 1935, viii, 1633: Arch. Path., 1936, xxii, 325; ibid., 1935, xx, 561. Google Scholar18. MOONKENNEDY VHPJ: Pathology of shock, Arch. Path., 1932, xiv, 360-371. Google Scholar19. OPIE EL: Desensitization to local action of antigen (Arthus phenomenon), 1924, ix, 247-268. Inflammation and immunity. Jr. Immunol., 1929, xvii, 329-342. Google Scholar20. PEARCEEISENBREY RMAB: Anaphylactic shock in the dog, Jr. Infect. Dis., 1910, vii, 565. CrossrefGoogle Scholar21. PETERSENJAFFELEVINSONHUGHES WFRHSATP: Endothelial permeability; endothelium in canine anaphylactic shock, Jr. Immunol., 1923, viii, 323-349: Jr. Biol. Chem., 1925, lxiii, 179. Google Scholar22. PORTIERRICHET PC: De l'action anaphylactique de certains venins, Compt. rend Soc. d. biol., 1902, liv, 170. Google Scholar23. RICHET C: Anaphylaxis, 1913, Liverpool University Press. Google Scholar24. SCHULTZ WH: Physiologic studies in anaphylaxis, Jr. Pharm. and Exper. Therap., 1912, iii, 299. Google Scholar25. SEEGAL BC: Agents of disease and host resistance, by Gay, F. P. et al., 1935, Thomas, Baltimore, chapter vi. Google Scholar26. SHATTUCK HF: Protein intoxication, Arch. Int. Med., 1917, xx, 167. CrossrefGoogle Scholar27. TOPLEYWILSON WWGS: Principles of bacteriology and immunology, 1936, Wm. Wood and Co., Baltimore. Google Scholar28. WEIL R: (1) The nature of anaphylaxis and the relations between anaphylaxis and immunity. (2) Studies in anaphylaxis, Jr. Med. Res., 1912, xxvii, 497; 1914, xxx, 87, 299. Anaphylaxis of dog, Jr. Immunol., 1917, ii, 399, 525. Google Scholar29. WELLS HG: Present status of problems of anaphylaxis, Physiol. Rev., 1921, i, 44. Chemical pathology, 1925, W. B. Saunders, Philadelphia, p. 220-235. CrossrefGoogle Scholar30. WITZINGER O: Zur anaphylaktischen Analyse der Serumkrankheit, Ztschr. f. Kinderheilk., 1911, iii, 211. Google Scholar31. ZINSSER H: Resistance to infectious diseases, 1931, 4th ed., Macmillan, New York. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Philadelphia, Pennsylvania*Received for publication September 10, 1937.From the Department of Pathology, Jefferson Medical College, Philadelphia. 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