tbuckley/cabot-search huggingface dataset:
Pathogenesis of Hodgkin's Disease
Authors: M. H. Gordon
Journal: BMJ (1953)

The clinical picture is strikingly uniform from case- to case, and strongly resembles that of tuberculous spondylitis.The distinction may be made by the tuber- culin skin test, and is confirmed by the appearance of recalcification in the x-ray films within three months of the onset in the pyogenic cases.We believe that it is wise to immobilize these children during the active stage of the disease, but that unre- stricted activity can safely be allowed as soon as recalci- fication is evident in the x-ray films.We are most grateful to Mr. J. A.
Magnetic resonance imaging as a screening procedure for methotrexate induced liver damage
Authors: M. RADEMAKER, J.A.W. WEBB, D.G. LOWE, R.H. MEYRICK-THOMAS, J.D.T. KIRBY, D.D. MUNRO
Journal: British Journal of Dermatology (1987)

Journal Article Magnetic resonance imaging as a screening procedure for methotrexate induced liver damage Get access M. RADEMAKER, M. RADEMAKER Department of Dermatology, St Bartholomew's Hospital, West Smithfield, London, U.K. Dr M.Rademaker, Department of Dermatology, Glasgow Royal Infirmary, Glasgow G40SF., U.K. Search for other works by this author on: Oxford Academic Google Scholar J.A.W. WEBB, J.A.W. WEBB Department of Radiology, St Bartholomew's Hospital, West Smithfield, London, U.K. Search for other works by this author on: Oxford Academic Google Scholar D.G. LOWE, D.G. LOWE Department of Histopathology, St Bartholomew's Hospital, West Smithfield, London, U.K. Search for other works by this author on: Oxford Academic Google Scholar R.H. MEYRICK‐THOMAS, R.H. MEYRICK‐THOMAS Department of Dermatology, St Bartholomew's Hospital, West Smithfield, London, U.K. Search for other works by this author on: Oxford Academic Google Scholar J.D.T. KIRBY, J.D.T. KIRBY Department of Dermatology, St Bartholomew's Hospital, West Smithfield, London, U.K. Search for other works by this author on: Oxford Academic Google Scholar D.D. MUNRO D.D. MUNRO Department of Dermatology, St Bartholomew's Hospital, West Smithfield, London, U.K. Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 117, Issue 3, 1 September 1987, Pages 311–316, https://doi.org/10.1111/j.1365-2133.1987.tb04137.x Published: 01 September 1987
Nongenetic Male Pseudohermaphroditism and Reduced Prenatal Growth
Authors: Berenice B. Mendonca, Ana Elisa C. Billerbeck, Francis de Zegher
Journal: New England Journal of Medicine (2001)

To the Editor: Most cases of male pseudohermaphroditism have a genetic origin.1 A nongenetic variant of the disorder, characterized by reduced prenatal growth and the lack of evidence of any associated malformation or endocrinopathy,2 has not been established. We report here on a pair of twins (karyotype, 46,XY) who were born at term after a normal gestation sustained by one placenta. Monozygosity was corroborated by identity for seven informative DNA loci in six chromosomes (D5S818, D13S317, D7S820, VWA, FGA, THO1, and CSF1PO). One boy (birth weight, 3.0 kg; length, 48 cm) had normal genitalia. The twin (birth weight, 1.7 kg; . . .
The American Health Care System
Authors: John K. Iglehart
Journal: New England Journal of Medicine (1992)

Repeated, unsuccessful efforts throughout this century to create a national scheme of health insurance have left a clear message: most Americans prefer private insurance to plans mandated or operated by the government to finance their medical care. This preference is unique among the industrialized nations. But now, largely in response to soaring medical expenditures and demands by employers that costs be constrained, the very nature of the insurance industry is changing. Its fundamental risk-bearing function is being assumed by its best customers (employers), and carriers are entering the new world of managed care. This blurring of functions leaves the future . . .
Radiation and Human Health
Authors: Jane M. Orient
Journal: JAMA (1982)

To the Editor.—  Because of the favorable review in a recent issue ofThe Journal(1982;247:1637) of John Gofman's book Radiation and Human Health , 1 I purchased a copy, only to discover that it is an antinuclear diatribe rather than a serious scientific work. Its innuendos about the integrity and competence of scientists who disagree with the author serve as flags to stimulate closer scrutiny. The innovative method proposed for calculating the risk of cancer induced by low-dose radiation begins with doubtful assumptions and multiplies manyfold the error of values observed in epidemiologic studies. The results are then tabulated to three significant figures for use by compensation lawyers and policymakers. Such statistical esoterica as confounding variables, confidence limits, and goodness-of-fit tests are introduced, if at all, only to explain why actual observations do not confirm Gofman's predictions. While the reviewer commented on the large number of references, he did not
A randomized, controlled comparison of ibuprofen at the maximal over-the-counter dose compared with prescription-dose celecoxib on upper gastrointestinal mucosal injury
Authors: James M. Scheiman, Byron Cryer, Michael B. Kimmey, Richard I. Rothstein, Dennis S. Riff, Michael M. Wolfe
Journal: Clinical Gastroenterology and Hepatology (2004)
Viral Hepatitis
Authors: John R. Neefe
Journal: New England Journal of Medicine (1949)

DURING recent years, the importance of viral hepatitis as a public-health and military problem has become increasingly apparent. The term "viral hepatitis" is used to include as a group the forms of hepatitis caused by filterable infectious agents that apparently are primarily hepatotropic and produce, as their outstanding clinical manifestations, evidences of liver injury that may or may not be associated with phenomena suggesting an infectious origin.Viral hepatitis thus includes the two types of disease commonly referred to as infectious (epidemic) and homologous serum hepatitis. The available evidence indicates that at least two filterable agents, which tentatively can be . . .
"Munchausen" Coronary Artery Disease
Authors: Tsung O. Cheng, Jerry F. Meyer, George A. Kelser, Nyab Ali
Journal: Annals of Internal Medicine (1975)

Comments and Corrections1 April 1975"Munchausen" Coronary Artery DiseaseTSUNG O. CHENG, M.D., F.A.C.P., JERRY F. MEYER, M.D., GEORGE A. KELSER JR., M.D., F.A.C.P., NYAB ALI, M.D.TSUNG O. CHENG, M.D., F.A.C.P.Search for more papers by this author, JERRY F. MEYER, M.D.Search for more papers by this author, GEORGE A. KELSER JR., M.D., F.A.C.P.Search for more papers by this author, NYAB ALI, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-82-4-593 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: We wish to report the case of a patient with "Munchausen syndrome" who presented with cardiovascular complaints indicative of severe coronary artery disease.A 46-year-old white man was transferred to The George Washington University Hospital (GWUH) 5 days before Christmas 1974 because of preinfarction angina. He gave a history of typical angina for the past 2 months, which had become worse 10 days ago when he collapsed and was admitted to a local hospital. His angina did not respond to sublingual nitroglycerin, oral isosorbide dinitrate, and oral propranolol. The only medication that seemed to offer relief was... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: TSUNG O. CHENG, M.D., F.A.C.P.; JERRY F. MEYER, M.D.; GEORGE A. KELSERJR., M.D., F.A.C.P.; NYAB ALI, M.D. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byMunchausen syndrome revisitedMunchausen syndrome presenting as cardiovascular disease (cardiopathia fantastica)Cardiac Munchausen SyndromeMunchausen syndrome presenting as acute coronary syndromeMunchausen SyndromeMunchausen syndromeFactitious disorders presenting as acute emergenciesCardiac Munchausen's syndromeMunchausen Cases with ConnectionsCHARLES R. RETHY, M.D. 1 April 1975Volume 82, Issue 4 Page: 593-594 Keywords Angina Stable coronary artery disease ePublished: 1 December 2008 Issue Published: 1 April 1975 PDF downloadLoading ...
Measurement of the False Positive Rate in a Screening Program for Human Immunodeficiency Virus Infections
Authors: Donald S. Burke, John F. Brundage, Robert R. Redfield, James J. Damato, Charles A. Schable, Pamela Putman, Robert Visintine, Howard I. Kim
Journal: New England Journal of Medicine (1988)

In a program screening civilian applicants for U.S. military service for human immunodeficiency virus (HIV) infection, we studied the frequency of false positive diagnoses retrospectively among applicants seropositive for HIV in a subpopulation with a very low prevalence of infection. That subpopulation was defined as consisting of all applicants tested between October 16, 1985, and June 30, 1987, who were young (17 or 18 years of age) and resided in a rural county in a state with a low incidence of reported acquired immunodeficiency syndrome (n = 135,187). Serum specimens from 15 applicants positive for HIV in this low-prevalence subpopulation were retrieved from a serum bank and retested by two Western blot methods, radioimmunoprecipitation, and an immunoassay constructed from a molecularly cloned and expressed viral envelope polypeptide. Fourteen of the 15 samples were unequivocally positive on all retest assays, and 1 was negative. Thus, the measured rate of false positive diagnoses in this program was 1 in 135,187 persons tested. Factors important in achieving a low false positive rate were a redundant, multistep testing algorithm, conservative criteria for interpreting Western blots, the requirement that a second, newly drawn serum specimen be tested for verification before a diagnosis of HIV was considered established, and tight quality control of laboratory testing procedures. We conclude that a screening program for HIV infection in a low-prevalence population can have an acceptably low false positive rate. (N Engl J Med 1988; 319: 961–4.)
Rubella (German Measles)
Authors: Robert B. Kalmansohn
Journal: New England Journal of Medicine (1952)

THE following observations are based on 100 consecutive cases of rubella in patients admitted to the contagious wards of the United States Army Hospital, Fort Belvoir, Virginia, during a two-week period in January, 1952. Comprehensive reviews of this subject have been presented in the past.1 2 3 No attempt is made here to duplicate this material, but an effort is made to discuss hitherto undescribed clinical aspects of the disease.The patients were all male soldiers ranging in age from seventeen to twenty-five. Without exception they were seen in the hospital within twenty-four hours of the onset of the exanthem. In most . . .
Silent Myocardial Ischemia
Authors: Arthur J. Barsky
Journal: JAMA (1990)

The symptoms of organic disease vary widely among patients with the same tissue abnormality, because the experience of a symptom is shaped by the patient's perceptual and cognitive style. Thus, the relationship between myocardial ischemia and chest pain is variable in that many patients experience pain without ischemia and many others exhibit ischemia without pain—termed "silent" or "asymptomatic ischemia." Although the nature of the ischemic event may be important in determining the degree of associated pain, we suggest more study of the individual who perceives the event. Myocardial ischemia may not generate a spontaneous report of chest pain because the patient is generally hyposensitive to visceral sensation; because he or she is coping with the threat of heart disease by denying the evidence of it—ie, denying the pain to deny the disease; or because the patient misunderstands the cause and significance of a vague or ambiguous cardiac sensation, normalizing the symptom and misattributing it to a nonpathologic cause. (<i>JAMA</i>. 1990;264:1132-1135)
Incidence of primary skin cancer after organ transplantation: An 18-year single-center experience in Korea
Authors: Gyeong-Hun Park, Sung Eun Chang, Chong Hyun Won, Mi Woo Lee, Jee Ho Choi, Kee Chan Moon, Duck Jong Han, Su Kil Park, Jae-Joong Kim, Jae Won Lee, Sung-Gyu Lee
Journal: Journal of the American Academy of Dermatology (2013)
Hidradenitis suppurativa and inflammatory bowel disease: are they associated? Results of a pilot study
Authors: H.H. Van Der Zee, C.J. Van Der Woude, E.F. Florencia, E.P. Prens
Journal: British Journal of Dermatology (2009)

Background The co-occurrence of hidradenitis suppurativa (HS) and Crohn disease (CD) published in a few case reports resulted in the wide acceptance of an association between these two diseases. However, the combined prevalence of these diseases is currently unknown; furthermore, it is unknown whether this co-occurrence also applies for ulcerative colitis (UC). Objectives To estimate the prevalence of HS in patients with inflammatory bowel disease (IBD) living in the Southwest of the Netherlands. Methods During an IBD patient information meeting, randomly, 158 patients with IBD were interviewed about recurrent painful boils in the axillae and/or groin and were shown illustrative clinical pictures of the appearance of HS. Results Of the 158 patients interviewed, 102 (65%) had CD and 56 (35%) had UC. Twenty-five people (16%) responded that they had had or still experienced painful boils in the axillae and/or groin, of whom 17 were patients with CD (17%) and eight had UC (14%). Conclusions This pilot study shows for the first time that HS occurs in patients with CD or UC. More prospective studies are warranted to establish the association between HS and IBD and its underlying pathogenesis.
Differentiation of liver progenitor cell line to functional organotypic cultures in 3D nanofibrillar cellulose and hyaluronan-gelatin hydrogels
Authors: Melina M. Malinen, Liisa K. Kanninen, Anne Corlu, Helena M. Isoniemi, Yan-Ru Lou, Marjo L. Yliperttula, Arto O. Urtti
Journal: Biomaterials (2014)

Physiologically relevant hepatic cell culture models must be based on three-dimensional (3D) culture of human cells. However, liver cells are generally cultured in two-dimensional (2D) format that deviates from the normal in vivo morphology. We generated 3D culture environment for HepaRG liver progenitor cells using wood-derived nanofibrillar cellulose (NFC) and hyaluronan-gelatin (HG) hydrogels. Culture of undifferentiated HepaRG cells in NFC and HG hydrogels induced formation of 3D multicellular spheroids with apicobasal polarity and functional bile canaliculi-like structures, structural hallmarks of the liver tissue. Furthermore, hepatobiliary drug transporters, MRP2 and MDR1, were localized on the canalicular membranes of the spheroids and vectorial transport of fluorescent probes towards the biliary compartment was demonstrated. Cell culture in 3D hydrogel supported the mRNA expression of hepatocyte markers (albumin and CYP3A4), and metabolic activity of CYP3A4 in the HepaRG cell cultures. On the contrary, the 3D hydrogel cultures with pre-differentiated HepaRG cells showed decreasing expression of albumin and CYP3A4 transcripts as well as CYP3A4 activity. It is concluded that NFC and HG hydrogels expedite the hepatic differentiation of HepaRG liver progenitor cells better than the standard 2D culture environment. This was shown as improved cell morphology, expression and localization of hepatic markers, metabolic activity and vectorial transport. The NFC and HG hydrogels are promising materials for hepatic cell culture and tissue engineering.
Plagiarism in Residency Application Essays
Authors: Sameer Siddique, Harris V. Naina, Samar Harris
Journal: Annals of Internal Medicine (2010)

Letters7 December 2010Plagiarism in Residency Application EssaysJason P. Lott, MD, MSHPJason P. Lott, MD, MSHPFrom Yale University School of Medicine, New Haven, CT 06510.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-153-11-201012070-00018 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:Segal and colleagues (1) offer compelling evidence on the significant incidence of plagiarism among applicants' essays to select residency programs and conclude that “a concerted, nationwide effort to detect and deter plagiarism is warranted.” In an accompanying editorial, Papadakis and Wofsy (2) call attention to numerous online essay-revision services that aid and abet in “misrepresentation of the applicant's independent capability” and question whether the personal statement is “best left to history.”As a former member of various medical admissions committees, my reviews of personal statements were often wrought with skepticism precisely because of such concerns about their ...References1. Segal S, Gelfand BJ, Hurwitz S, Berkowitz L, Ashley SW, Nadel ES, et al. Plagiarism in residency application essays. Ann Intern Med. 2010;153:112-20. [PMID: 20643991] LinkGoogle Scholar2. Papadakis MA, Wofsy D. Plagiarism on personal statements: a disturbing symptom of a broader trend [Editorial]. Ann Intern Med. 2010;153:128-9. [PMID: 20643994] LinkGoogle Scholar Author, Article, and Disclosure InformationAffiliations: From Yale University School of Medicine, New Haven, CT 06510.Disclosures: None disclosed. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoPlagiarism in Residency Application Essays Scott Segal , Brian J. Gelfand , Shelley Hurwitz , Lori Berkowitz , Stanley W. Ashley , Eric S. Nadel , and Joel T. Katz Plagiarism on Personal Statements: A Disturbing Symptom of a Broader Trend Maxine A. Papadakis and David Wofsy Plagiarism in Residency Application Essays Sameer Siddique , Harris V. Naina , and Samar Harris Plagiarism in Residency Application Essays Moxie Stratton-Loeffler Plagiarism in Residency Application Essays Jonas B. Green Plagiarism in Residency Application Essays Michael Kirsch Response to Comments on Plagiarism in Residency Application Essays Scott Segal , Brian J. Gelfand , and Joel T. Katz Metrics Cited byPlagiarised letters of recommendation submitted for the National Resident Matching ProgramResponse to Comments on Plagiarism in Residency Application EssaysScott Segal, MD, MHCM, Brian J. Gelfand, MD, and Joel T. Katz, MD 7 December 2010Volume 153, Issue 11Page: 765KeywordsConflicts of interestResidency ePublished: 7 December 2010 Issue Published: 7 December 2010 Copyright & PermissionsCopyright © 2010 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Multiple Skin-Colored Papules With Diffuse Sclerosis
Authors: Danielle S. Applebaum, Seema Daulat, Madeleine Duvic
Journal: JAMA Dermatology (2014)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Dermatology HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Dermatology journal
Less specific myositis autoantibodies?
Authors: R MIERAU
Journal: Annals of the Rheumatic Diseases (2001)

Brouwer et al studied a very large group of European patients with idiopathic inflammatory myopathies for myositis associated autoantibodies with a variety of methods.1 This is the largest group of patients with myositis ever studied for autoantibodies. The results substantially increase the existing knowledge about frequencies of autoantibodies in patients with inflammatory myopathies.

Compared with the pre-existing data, clinical associations of certain myositis-specific autoantibodies seem to be widening and are becoming less specific. Whereas the overwhelming majority of patients with anti-SRP up until now were reported to have polymyositis (PM),2 3 and anti-Mi-2 was almost completely specific for dermatomyositis (DM),3-5 Brouwer et al mention several anti-SRP positive DM and anti-Mi-2 positive PM cases, and even some patients with these autoantibodies and inclusion body myositis. The question is whether this is a matter of test or autoantibody specificity or a problem of adequate clinical diagnosis or classification as PM or DM. Moreover, the specificity of myositis related autoantibodies is further questioned by several violations of the well established rule that coincidences of myositis-specific antibodies are almost non-existent6—for example, by patients being positive for anti-Jo-1 and anti-Mi-2 or anti-SRP at the same time.

As the authors correctly state, the detection of more positive results is mostly due to the assay design, …
The Genetics of Mental Disorders
Authors: Philip L. Townes
Journal: JAMA (1972)

This is a modest title for this exceedingly well-written text which deals most comprehensively with considerably more than this rather vast subject. The "genetics" of schizophrenia, the affective psychoses, senile and presenile dementias have long posed many imponderable problems. While there is considerable evidence for genetic predisposition for this complex group of disorders, specific modes of inheritance remain unclear. To a great extent, genetic analysis is complicated by the very poorly defined and unmeasurable environmental factors that modulate expression of genetic predisposition. To this difficult problem the authors have very effectively addressed themselves. Chapters 2 through 9 comprise a very detailed review of the evidence for genetic predisposition and an objective anlaysis of the data in terms of several genetic models. In their analysis, the authors reach conclusions supported by the data but they critically resist the oversimplification and dogma advanced by others in an attempt to establish the "genetics"
PROVIDER VARIABILITY AND CHARACTERISTICS ASSOCIATED WITH BIVALIRUDIN USE FOR BLEEDING AVOIDANCE IN PERCUTANEOUS CORONARY INTERVENTION AFTER IMPLEMENTATION OF A DECISION SUPPORT TOOL
Authors: Timothy J. Fendler, Philip Jones, Henry Ting, Faraz Kureshi, Adam Salisbury, Praneet Sharma, Adnan Chhatriwalla, John Spertus
Journal: Journal of the American College of Cardiology (2014)