RENAL FAILURE IN LAENNEC'S CIRRHOSIS OF THE LIVER. I. DESCRIPTION OF CLINICAL AND LABORATORY FEATURES
Authors: Solomon Papper, Joseph L. Belsky, Kenneth H. Bleifer
Journal: Annals of Internal Medicine (1959)

Article1 October 1959RENAL FAILURE IN LAENNEC'S CIRRHOSIS OF THE LIVER. I. DESCRIPTION OF CLINICAL AND LABORATORY FEATURESSOLOMON PAPPER, M.D., JOSEPH L. BELSKY, M.D., KENNETH H. BLEIFERSOLOMON PAPPER, M.D.Search for more papers by this author, JOSEPH L. BELSKY, M.D.Search for more papers by this author, KENNETH H. BLEIFERSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-51-4-759 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptIn 1863 Austin Flint first called attention to the presence of oliguria in patients with cirrhosis of the liver and hydroperitoneum.1Since that time it has become quite apparent that oliguria is extremely common in patients with cirrhosis and marked ascites. This decreased urine flow is generally not associated with striking diminution in glomerular filtration rate (GFR) or rise in blood nonprotein nitrogen concentration;2rather, the oliguria is usually attributable to the decreased solute load, especially sodium, that is presented for excretion. However, in some instances, decreased urine flow in patients with cirrhosis is accompanied by azotemia. While we have...Bibliography1. Flint A: Clinical report on hydro-peritoneum, based on an analysis of forty-six cases, Am. J. M. Sc. 45: 306-339, 1863. CrossrefGoogle Scholar2. Papper S: The role of the kidney in Laennec's cirrhosis of the liver, Medicine 37: 299-316, 1958. CrossrefMedlineGoogle Scholar3. HeckerSherlock RS: Electrolyte and circulatory changes in terminal liver failure, Lancet 2: 1121-1125, 1956. CrossrefGoogle Scholar4. PapperSaxon SL: The diuretic response to administered water in liver disease. II. Laennec's cirrhosis, Arch. Int. Med. 103: 750-757, 1959. CrossrefGoogle Scholar5. StraussRaisz MBLG: Clinical management of renal failure, 1956, Charles C Thomas, Springfield, Illinois. Google Scholar6. PopperSchaffner HF: Liver structure and function, 1957, Blakiston Division, McGraw-Hill, New York. Google Scholar7. Boyce FF: The role of the liver in surgery, 1941, Charles C Thomas, Springfield, Illinois. CrossrefGoogle Scholar8. Shorr E: Hepatorenal vasotropic factors in experimental cirrhosis, in Conference on liver injury, sixth, May 1-2, 1947, Transactions, 1947, Josiah Macy, Jr. Foundation, New York. Google Scholar9. ShorrZweifachFurchgott EBWRF: Hepatorenal factors in circulatory hemostasis; influence of humoral factors of hepato-renal origin on vascular reactions to hemorrhage, Ann. New York Acad. Sc. 49: 571-592, 1948. CrossrefMedlineGoogle Scholar10. BaezMazurShorr SAE: Hepatorenal factors in circulatory homeostasis. XX. Antidiuretic action of hepatic vasodepressor, VDM (Ferritin), Am. J. Physiol. 162: 198-212, 1950. CrossrefMedlineGoogle Scholar11. FazekasTictinEhrmantrantAlman JFHEWRRW: Cerebral metabolism in hepatic insufficiency, Am. J. Med. 21: 843-849, 1956. CrossrefMedlineGoogle Scholar12. PapperDavidsonEarleyLancestremereO'Brien SPLLERGFJ: Unpublished observations. Google Scholar13. KowalskiAbelmann HJWH: The cardiac output at rest in Laennec's cirrhosis, J. Clin. Investigation 32: 1025-1033, 1953. CrossrefMedlineGoogle Scholar14. MurrayDawsonSherlock JFAMS: Circulatory changes in chronic liver disease, Am. J. Med. 24: 358-367, 1958. CrossrefMedlineGoogle Scholar15. RelmanSchwartz ASWB: The nephropathy of potassium depletion, New England J. Med. 255: 195-203, 1956. CrossrefMedlineGoogle Scholar16. ThoringtonSchmidt JMCF: A study of the urinary output and blood-pressure changes resulting in experimental ascites, Am. J. M. Sc. 165: 880, 1923. CrossrefGoogle Scholar17. BradleyBradley SEGP: The effect of increased intra-abdominal pressure on renal function in man, J. Clin. Investigation 26: 1010-1022, 1947. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: SOLOMON PAPPER, M.D.; JOSEPH L. BELSKY, M.D.; KENNETH H. BLEIFER*Received for publication May 12, 1959.Presented in part at the Fortieth Annual Session of The American College of Physicians, Chicago, Illinois, April 20, 1959.From the Medical Service and Research Laboratory, Boston Veterans Administration Hospital, and the Departments of Medicine, Tufts University School of Medicine and Boston University School of Medicine.Requests for reprints should be addressed to Solomon Papper, M.D., Assistant Chief, Medicine, Veterans Administration Hospital, 150 South Huntington Avenue, Boston 30, Massachusetts. 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COLMAN, M.D., F.A.C.P., RICHARD C. TALAMO, M.D., BERNARD M. BABIOR, M.D., Ph.D.Renal blood flow in malignant disease of the liverThe effect of octapressin on renal and intrarenal blood flow in cirrhosis of the liverRENAL AND INTRARENAL BLOOD-FLOW IN CIRRHOSIS OF THE LIVERRenal failure in the patient with cirrhosisFunctional Renal Failure in Cirrhosis Recovery After Portacaval ShuntEDWARD T. SCHROEDER, M.D., PATRICIA J. NUMANN, M.D., BRUCE E. CHAMBERLAIN, M.D.Combined Ascitic-Fluid and Furosemide Infusion in the Management of AscitesTransplantation of Cadaveric Kidneys from Patients with Hepatorenal SyndromeDas morphologische Substrat der LeberinsuffizienzManagement of postoperative acute renal failureDas sogenannte hepatorenale SyndromCase 42-1967Acute renal failure in association with fatty liver of pregnancyTHE COMPLICATIONS OF DIURETIC THERAPY IN PATIENTS WITH CIRRHOSISPrognosis in Acute Liver Disease of the Alcoholic PatientRenal Failure with Cirrhosis Observations on the Role of DiureticsFRED L. LIEBERMAN, M.D., TELFER B. REYNOLDS, M.D., F.A.C.P.COMPLICATIONS OF DIURETIC THERAPY IN HEPATIC CIRRHOSISPartialfunktionen der Niere bei Cirrhosis hepatisÜber Hemmwirkungen des Serums von Kranken mit hepatorenalem Syndrom und mit chronischer Urämie auf Sauerstoffverbrauch und Kohlenhydratstoffwechsel von Nieren- und Hirngewebe der RatteRenal failure in patients with cirrhosis of the liverRenal failure in patients with cirrhosis of the liverSpontaneous Recovery from the Hepatorenal SyndromeACUTE RENAL FAILURE AFTER ORAL CHOLECYSTOGRAPHYThe Kidney in Cirrhosis I. Clinical and Biochemical Features of Azotemia in Hepatic FailureWILLIAM P. BALDUS, M.D., RALPH N. FEICHTER, M.D., WILLIAM H. J. SUMMERSKILL, M.D.The Kidney in Cirrhosis II. Disorders of Renal FunctionWILLIAM P. BALDUS, M.D., RALPH N. FEICHTER, M.D., WILLIAM H. J. SUMMERSKILL, M.D., JAMES C. HUNT, M.D., KHALIL G. WAKIM, M.D.Hepatic comaPROBLEMS IN THE MANAGEMENT OF ACUTE RENAL FAILUREPhysiology of Body Water and Electrolytes in Hepatic DiseaseStudies of the Cardiovascular System in the Hypotension of Liver FailureCase 48-1962Reversible hyponatremia and azotemia in a patient with cirrhosis and ascitesMedical Management of the Preoperatively and Postoperatively Jaundiced PatientLong-term medical management and complications of `resistant' ascitesIsotope Studies of the Development of Water and Electrolyte Disorders and Azotemia During the Treatment of AscitesRenal Failure in Association With Severe Liver Diseases and Obstructive Jaundice (hepatorenal Syndrome)The liver and Its DiseasesPathogenesis and Treatment of Hepatic Failure 1 October 1959Volume 51, Issue 4 Page: 759-773 Keywords Ascites Attention Cirrhosis Hospital medicine Liver Pathogenesis Renal failure Research laboratories Sodium Urine ePublished: 1 December 2008 Issue Published: 1 October 1959 PDF downloadLoading ...