tbuckley/cabot-search huggingface dataset:
Operative Treatment of Duodenal Ulcer: Transatlantic Data and Opinion
Authors: Francis D. Moore
Journal: New England Journal of Medicine (1974)

During the past year two randomized trials of surgical operations for definitive management of duodenal ulcer have been published. One by Postlethwait1 is a study of 1357 patients operated on in Veterans Administration hospitals. The series is almost equally divided among four categories — vagotomy and drainage, vagotomy and antrectomy, vagotomy and hemigastrectomy, and classic gastric resection. Truncal vagotomy was used.A somewhat contrasting study was carried out in Glasgow, by Kay and his colleagues, reporting 547 patients all of whom had truncal vagotomy,2 the object of the study being to contrast the results of various drainage operations. About 200 . . .
Patient with tuberculosis who flew internationally has surgery and is sued by passengers
Authors: Janice Hopkins Tanne
Journal: BMJ (2007)

A "cock-up" by the UK government has impeded the ability of the Healthcare Commission to assess independent sector treatment centres (ISTCs), says the watchdog's chief executive, Anna Walker.She says that a government oversight has impeded the commission's ability to assess the safety and quality of the centres.The commission declared this week that the Department of Health had failed to ensure that the data collected on the controversial clinics were compatible with the data used to monitor the rest of the NHS.The commission had aimed to review the first 23 centres, which were set up to carry out high volumes of straightforward elective surgery to cut NHS waiting lists.The commission interviewed 2000 patients, made inspections, and checked health records.Ms Walker said that there were gaps, however, because "comparative data has not been systematically collected."Where independent providers serve NHS patients we must ensure we have the proper systems to provide reassurance about what is being provided," she said."That is why we are calling for one sys-tem that allows comparable information to be published on all major healthcare providers, whether public or private, whether they are treating NHS patients or otherwise."Beginning in October, the Royal College of Surgeons will carry out its own study, funded by the Department of Health, to assess the success of operations carried out in the centres.Bernard Ribeiro, president of the Royal College of Surgeons, said, "It is imperative that patients receive a sustained, safe, and [high] quality service, which is consistent across surgical providers."See www.healthcarecommission.org.uk. Failure to monitor independent centres prevents comparison, say�s watchdog
HYPOXIA LIMITS THE CARDIAC REGENERATIVE POTENTIAL OF HYPOXIA-INDUCIBLE- FACTOR-1ALPHA TRANSDUCED CARDIAC-DERIVED STEM CELLS
Authors: Michail Bonios, John Terrovitis, Connie Chang, Aurelio Pinheiro, James Engles, Andreas Barth, Pei Dong, Veronica Lea Dimaano, Miguel Aon, Inhwa Tina Lee, Christina Melexopoulou, Richard Wahl, Brian O’ Rourke, Theodore Abraham, Roselle Abraham
Journal: Journal of the American College of Cardiology (2010)
The Hospital versus the Home in the Care of the Sick; An Evolution
Authors: P. E. Truesdale
Journal: JAMA (2014)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
NHS sets up unit to reduce carbon emissions in health service
Authors: Henry Creagh
Journal: BMJ (2008)

The government is spending £0.5m (€0.7m; $1m) on a new body that will monitor and encourage energy efficient practices throughout the NHS in England.

The NHS Sustainable Development Unit, which is to be based in the East of England NHS region, is intended to set out evaluation systems and identify good practice for energy use in all aspects of health service activity.

David Pencheon, who is setting up the unit, said that its role will be to build on efforts to reduce carbon emissions in the health service.

He was keen to allay fears that this …
Multiple Muscle Herniae
Authors: I. D. Kitchin, D. A. Richmond
Journal: BMJ (1943)

MENINGITIS DUE TO DIPLOCOCCUS MUCOSUS MEDICALTouS found that the strabismus had existed since childhood.The pupils were dilated but reacted normally to light.Abdominal and plantar reflexes were normal.There was a leucocytosis of 12,400.Lumbar puncture soon after admission yielded a turbid fluid under increased pressure.Sulphapyridine was given by the mouth, the initial dose being 2 g.Oral administration was satisfactory, and 9 g. were given in the first 24 hours.The patient rapidly became quieter, and the temperature had fallen to 99.4°F.by the following morning.The general condition was better, the headache less severe, and the mental state normal.The rash had almost completely faded, but petechiae were noted on the antenor aspect of the legs and there was a circular purpuric patch an inch in diameter on the right calf.The ptosis persisted and neck rigidity was still present, but Kernig's sign was negative.Lumbar puncture again yielded a turbid fluid; the pressure was normal.Sulphapyridine was continued in a dosage of 1 g.every 4 hours.Improvement continued, and during the next few days the rigidity, ptosis, and headache abated.The dosage of sulphapyridine was decreased and the drug was discontinued on June 5., a total of 22 g.having been given.A slight right otitis externa, noticed on June 8, responded quickly to treatment.Convalescence was rapid, and no abnormality was detected on routine examination on June 14.
AUTOPSY REPORT OF A CASE OF SO-CALLED JAKE PARALYSIS
Authors: Hugh Jeter
Journal: JAMA (1930)

About 300 cases of so-called Jake paralysis have been reported in Oklahoma City in the past two months. Briefly, these cases present the following symptoms: Sudden onset, with cramps and soreness of the calf muscles, followed in a few hours by complete bilateral paralysis of the anterior and posterior tibial nerves. In most cases, but not in all, there is a paralysis of the musculospiral, median and ulnar nerves. Pain, touch and thermal sensations are not disturbed, but paresthesia is present in many cases. The function of the cranial nerves is normal. Fundus examinations have been negative. In none of the cases reported have there been sphincter disturbances. Blood counts, complement fixation tests and urinalyses have proved irrelevant. In one case, I found stippling of the red cells, but this patient had been a painter for thirty years. All of these patients have been addicted to alcohol, and nearly all
The same sequence variant on 9p21 associates with myocardial infarction, abdominal aortic aneurysm and intracranial aneurysm
Authors: Anna Helgadottir, Gudmar Thorleifsson, Kristinn P Magnusson, Solveig Grétarsdottir, Valgerdur Steinthorsdottir, Andrei Manolescu, Gregory T Jones, Gabriel J E Rinkel, Jan D Blankensteijn, Antti Ronkainen, Juha E Jääskeläinen, Yoshiki Kyo, Guy M Lenk, Natzi Sakalihasan, Konstantinos Kostulas, Anders Gottsäter, Andrea Flex, Hreinn Stefansson, Torben Hansen, Gitte Andersen, Shantel Weinsheimer, Knut Borch-Johnsen, Torben Jorgensen, Svati H Shah, Arshed A Quyyumi, Christopher B Granger, Muredach P Reilly, Harland Austin, Allan I Levey, Viola Vaccarino, Ebba Palsdottir, G Bragi Walters, Thorbjorg Jonsdottir, Steinunn Snorradottir, Dana Magnusdottir, Gudmundur Gudmundsson, Robert E Ferrell, Sigurlaug Sveinbjornsdottir, Juha Hernesniemi, Mika Niemelä, Raymond Limet, Karl Andersen, Gunnar Sigurdsson, Rafn Benediktsson, Eric L G Verhoeven, Joep A W Teijink, Diederick E Grobbee, Daniel J Rader, David A Collier, Oluf Pedersen, Roberto Pola, Jan Hillert, Bengt Lindblad, Einar M Valdimarsson, Hulda B Magnadottir, Cisca Wijmenga, Gerard Tromp, Annette F Baas, Ynte M Ruigrok, Andre M van Rij, Helena Kuivaniemi, Janet T Powell, Stefan E Matthiasson, Jeffrey R Gulcher, Gudmundur Thorgeirsson, Augustine Kong, Unnur Thorsteinsdottir, Kari Stefansson
Journal: Nature Genetics (2008)
Health, Medical Care, and Economic Crisis
Authors: Ralph Catalano
Journal: New England Journal of Medicine (2009)

On December 1, 2008, the National Bureau of Economic Research declared that the U.S. economy had been in recession since December 2007. The number of Americans seeking unemployment compensation has reached levels unmatched since 1983, when we were suffering the worst recession since the Great Depression. Intuition suggests that the fear or experience of job loss, coupled with the declining value of homes and investments, makes many of us anxious, causes us to reduce discretionary spending (including that on medical care), and distracts us from taking preventive measures. Many physicians may therefore assume that our economic crisis will increase the . . .
National Institutes of Health criticised for not preventing conflicts of interest
Authors: Janice Hopkins Tanne
Journal: BMJ (2004)

The US National Institutes of Health (NIH) has been criticised by members of Congress for letting employees accept lucrative consultancy assignments from drug and biotechnology companies.

On 22 June the director of the NIH, Dr Elias Zerhouni, told the House Energy and Commerce Oversight and Investigations Subcommittee, “In retrospect, there was not a sufficient safeguard against the perception of conflict of interest.” He said the NIH would tighten rules about employees' consultancy work.

The NIH's troubles began on 7 December 2003. …
Two Hundred and Fifty Years of the Westminster
Authors: G. Keynes
Journal: BMJ (1967)

As the author points out in his preface, although patients with head injuries in whom severe complications arise are commonly transferred to special units, other patients, and indeed the majority, are of necessity cared for in the hospital to which they are first admitted.This book is written primarily for surgeons and doctors who have had no neuro- surgical training and who are called upon to care for such patients.The writer has had a long experience of head injuries, at Oxford, in the Army, and latterly at Cambridge, and his interest has been manifest in numerous articles and in his activities in the organization of accident services.The book is written in a clear, simple, and concise style and is " arranged from the view- point of a doctor called to see an acute head injury."Emphasis is placed upon " the need to seek a clinical diagnosis of the extent and
COMPARISON OF TRANSCATHETER AND SURGICAL AORTIC VALVE REPLACEMENT IN SEVERE AORTIC STENOSIS: A LONGITUDINAL STUDY OF ECHO PARAMETERS IN COHORT A OF THE PARTNER TRIAL
Authors: Rebecca T. Hahn, Philippe Pibarot, William J. Stewart, Neil J. Weissman, Augusto Pichard, Howard C. Herrmann, Martin Leon, Susheel Kodali, Vinod Thourani, Lars Svensson, Pamela Douglas
Journal: Journal of the American College of Cardiology (2013)
Manganese: brain transport and emerging research needs.
Authors: M Aschner
Journal: Environmental Health Perspectives (2000)

Idiopathic Parkinson's disease (IPD) represents a common neurodegenerative disorder. An estimated 2% of the U.S. population, age 65 and older, develops IPD. The number of IPD patients will certainly increase over the next several decades as the baby-boomers gradually step into this high-risk age group, concomitant with the increase in the average life expectancy. While many studies have suggested that industrial chemicals and pesticides may underlie IPD, its etiology remains elusive. Among the toxic metals, the relationship between manganese intoxication and IPD has long been recognized. The neurological signs of manganism have received close attention because they resemble several clinical disorders collectively described as extrapyramidal motor system dysfunction, and in particular, IPD and dystonia. However, distinct dissimilarities between IPD and manganism are well established, and it remains to be determined whether Mn plays an etiologic role in IPD. It is particularly noteworthy that as a result of a recent court decision, methylcyclopentadienyl Mn tricarbonyl (MMT) is presently available in the United States and Canada for use in fuel, replacing lead as an antiknock additive. The impact of potential long-term exposure to low levels of MMT combustion products that may be present in emissions from automobiles has yet to be fully evaluated. Nevertheless, it should be pointed out that recent studies with various environmental modeling approaches in the Montreal metropolitan (where MMT has been used for more than 10 years) suggest that airborne Mn levels were quite similar to those in areas where MMT was not used. These studies also show that Mn is emitted from the tail pipe of motor vehicles primarily as a mixture of manganese phosphate and manganese sulfate. This brief review characterizes the Mn speciation in the blood and the transport kinetics of Mn into the central nervous system, a critical step in the accumulation of Mn within the brain, outlines the potential susceptibility of selected populations (e.g., iron-deficient) to Mn exposure, and addresses future research needs for Mn.
Hematopoietic NF-κB1 deficiency results in small atherosclerotic lesions with an inflammatory phenotype
Authors: Edwin Kanters, Marion J.J. Gijbels, Ingeborg van der Made, Monique N. Vergouwe, Peter Heeringa, Georg Kraal, Marten H. Hofker, Menno P. J. de Winther
Journal: Blood (2003)
Hypoxemia during Air Travel in Patients with Chronic Obstructive Pulmonary Disease
Authors: Thomas A. Dillard, Benjamin W. Berg, Krishnan R. Rajagopal, James W. Dooley, William J. Mehm
Journal: Annals of Internal Medicine (1989)

Study Objective: To quantitate and identify determinants of the severity of hypoxemia during air travel in patients with chronic obstructive pulmonary disease. Design: Prospective study of physiologic variables before and during intervention. Setting: Referral-based pulmonary disease clinic at a U.S. Army medical center. Patients: Eighteen ambulatory retired servicemen (age 68 ± 6 [SD] years) with severe chronic obstructive pulmonary disease (forced expiratory volume in the first second [FEV1] 31% ± 10% of predicted). Intervention: Altitude simulation equivalent to 2438 meters (8000 feet) above sea level in a hypobaric chamber. Measurements and Main Results: Radial artery catheter blood oxygen tension in the patients declined from a ground value (PaO2G) at sea level of 72.4 ± 9 mm Hg to an altitude value (PaO2Alt) of 47.4 ± 6 mm Hg after 45 minutes of steady state hypobaric exposure. The PaO2G correlated with PaO2Alt (r = 0.587; P < 0.01). Multiple regression analysis revealed that the preflight FEV1 reduced the variability in PaO2Alt not explained by PaO2G in the equation: PaO2Alt = 0.453 [PaO2G] + 0.386 [FEV1% predicted] + 2.440 (r = 0.847; P < 0.001). Residuals from two previously published formulas using PaO2G also correlated with FEV1 (r ≥ 0.765; P < 0.001). Conclusions: Arterial blood oxygen tension declined to clinically significant levels in most patients during hypobaric exposure. When combined with the preflight arterial PO2 at ground level (PaO2G), the measurement of the preflight FEV1 improved prediction of PaO2 at altitude (PaO2Alt) in patients with severe chronic obstructive pulmonary disease.
Report: Improvements Needed to Protect Food Supply From Potential Threats
Authors: Mike Mitka
Journal: JAMA (2008)

WHILE THE UNITED STATES HAS one of the safest food supplies in the world, new food sources, changes in production and distribution methods, importation, and the threat of deliberate contamination suggest that more needs to be done to protect the public from foodborne disease, according to a new report. The report, issued on April 30 by Trust for America’s Health, a nonprofit, nonpartisan organization, argues that the nation’s food security system has major flaws in its ability to protect consumers. The group says that the system has not been fundamentally modernized in more than 100 years, has inadequate resources to fight modern bacterial threats, and has been crippled by reductions in the numbers of food inspectors and scientists at agencies responsible for food safety. In addition, the group noted, 15 federal agencies operating under at least 30 laws are involved in food safety, with no single department responsible for the overall protection of the food supply. Thereport,FixingFoodSafety:ProtectingAmerica’sFoodSupplyFromFarm-toFork(http://healthyamericans.org/reports /foodsafety08/FoodSafety08.pdf), was supported by a grant from the Robert Wood Johnson Foundation.
Toward Universal Vaccination against Hepatitis B Virus
Authors: Jay H. Hoofnagle
Journal: New England Journal of Medicine (1989)

The first vaccine against human hepatitis B virus was licensed for use in the United States in 1981 and became commercially available in 1982.1 The development of this vaccine represented a milestone in medicine and was the product of two decades of intensive research into the structure and biology of hepatitis B virus. The first vaccine consisted of particles of purified and inactivated hepatitis B surface antigen (HBsAg) extracted from pooled plasma from long-term carriers of HBsAg. A second milestone was reached in 1984 with the development of a recombinant hepatitis B vaccine, the first human vaccine produced with molecular . . .
Gynaecologists cleared of wrongdoing after death of patient
Authors: O. Dyer
Journal: BMJ (2002)

Two gynaecologists accused of a catalogue of errors that led to the death of a woman after a hysterectomy were cleared last week of any clinical wrongdoing by the General Medical Council.

Professor Stuart Campbell and Mr Christoph Lees, both consultants in obstetrics and gynaecology, were also cleared of failing to obtain fully informed consent from Mrs Monica Crockett, 67,\who died in September 1997 at St George's Hospital, London, after undergoing surgery for an ovarian cyst.

Professor Campbell originally planned to treat Mrs Crockett by laparoscopic surgery. Mr …
Amino acid derivatives as transdermal permeation enhancers
Authors: Barbora Janůšová, Barbora Školová, Katarína Tükörová, Lea Wojnarová, Tomáš Šimůnek, Přemysl Mladěnka, Tomáš Filipský, Michal Říha, Jaroslav Roh, Karel Palát, Alexandr Hrabálek, Kateřina Vávrová
Journal: Journal of Controlled Release (2012)
INTESTINAL INDIGESTION IN AN INFANT FROM HAM RIND.
Authors: BLANCH N. EPLER
Journal: JAMA (1905)

<h3>Patient.</h3> —A child, aged 2 years, a patient of Dr. Della Pierce, had complained of vomiting, abdominal pains and diarrhea for two days. <h3>History.</h3> —There was a history of an intestinal indigestion and slight fever of several days' duration. The mother stated that during this time the child passed large pieces of "curd" in the stools. <h3>Course.</h3> —The symptoms abated with treatment, and several days later the child passed what the mother called a long, green worm. Recovery was rapid. The so-called worm certainly resembled one on gross inspection. It measured 8 inches and was flat, one side presenting a white curd-like appearance; the other a dull, green, slimy appearance. On careful examination, aided by the microscope and KOH, this substance proved to be the rind of ham or bacon, only slightly attacked by the digestive juices. This is a good example of what is to be expected in babies
MECHANICAL AID FOR THE ARM AMPUTEE
Authors: Jerome Weiss
Journal: JAMA (1952)

In recent years considerable advance has been made in the rehabilitation of the arm amputee by means of working prostheses. These are supplied with a prehensile hook operated by the opposite shoulder or by muscle motors produced surgically. For special purposes, modifications of the hook have been devised. Some prostheses provide for quick removal of the hook and replacement with a nonfunctioning hand for cosmetic effect. These prosthetic devices have done much to restore the usefulness and to elevate the morale of the arm amputee; however, there remain two important functions that are still difficult for him. These are the opening of an ordinary can, and the removing or replacing of a bulky top from a jar. Dunton and Licht<sup>1</sup>recognize the difficulty that the usefulness of only one arm imposes. No present arm prosthesis that is useful for ordinary purposes will satisfactorily hold a can or jar unless
A SIMPLE METHOD OF PRESCRIBING DIABETIC DIETS
Authors: GEORGE BAEHR
Journal: JAMA (1924)

All the so-called simple methods that have thus far been suggested as aids in prescribing modern diabetic diets require the use of a bewildering array of complicated mathematical formulas. The general practitioner, to whose lot must fall the treatment of the vast majority of patients with diabetes, will not use formulas. He finds it difficult even to translate the values for carbohydrate, protein and fat in these diets into the menus for three meals a day. And yet, the newer methods of treating diabetes (either with or without insulin) demand that each case be treated differently, that the amount of glucose burning ability still remaining in each diabetic patient be determined as accurately as possible, and that, in each instance, the diet prescribed be designed to meet the particular need of that individual. This becomes even more important whenever insulin is to be used. Table 1 has therefore been devised
IS SULPHUR HELPFUL OH HARMFUL IN ACNE VULGARIS?
Authors: OTTO H. MILLS, ALBERT M. KLIGMAN
Journal: British Journal of Dermatology (1972)

Journal Article IS SULPHUR HELPFUL OH HARMFUL IN ACNE VULGARIS? Get access OTTO H. MILLS, Jr., OTTO H. MILLS, Jr. Department of Dermatology, Univrsity of Pennsylvania, School of Medicine, Philadelphia, Pe sylvania, U.S.A Search for other works by this author on: Oxford Academic Google Scholar ALBERT M. KLIGMAN ALBERT M. KLIGMAN Department of Dermatology, Univrsity of Pennsylvania, School of Medicine, Philadelphia, Pe sylvania, U.S.A Requests for reprints should addressed to the Department of Dermatology, Hospital of the University of Pennsylvania, Duhring Laboratories, 3600 Spruce Street, Philadelphia, Pennsylvania 19104 (Dr Kligman). Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 86, Issue 6, 1 June 1972, Pages 620–627, https://doi.org/10.1111/j.1365-2133.1972.tb05078.x Published: 01 June 1972 Article history Accepted: 17 January 1972 Published: 01 June 1972