tbuckley/cabot-search huggingface dataset:
Editorial
Authors: HOWARD B. SPRAGUE
Journal: Circulation (1958)

DiseaseT WO major theories of causation of coro- nary atherosclerosis are now popular.One relates the pathology to an abnormal lipid level in the blood, either total lipid or some fraction of lipoprotein.The other, that of the school of Rokitanskyl and Duguid,2 considers the cholesterol deposit to be secondary to the damage from repeated thrombotic injury in- effectively neutralized by normal fibrinolytic mechanisms.It is possible that both of these may be related in some way to abnormalities of fat metabolism in that thrombotic episodes appear to be more common in populations with high fat intakes.There seems to be some pressure, by those psychosomatically oriented, to admit the camel of atherosclerosis into the spiritual tent, even though, up to now, his nose is the only part even suggestively inside.By this I mean that emotional stress is being proposed as the agent through which lipids appear in coronary ves- sels, and that is why coronary disease is in- creasing in what is supposed to be an unusual- ly anxious age in world history.Just how this happens we are yet to be told.This point of view presents dangers.It is an easy way out because it almost precludes scientific investigation.No one can prove that
Bone Scan in Inferior Vena Cava Obstruction
Authors: DEAN J. RODMAN, LEWIS K. ATKINSON, DANIEL D. MAXWELL, PAUL L. CHANDEYSSON
Journal: Clinical Nuclear Medicine (1990)

RODMAN, DEAN J. M.D.; ATKINSON, LEWIS K. M.D.; MAXWELL, DANIEL D. M.D.; CHANDEYSSON, PAUL L. M.D. Author Information
High-Frequency Direct Body Ballistocardiography: A New Concept.
Authors: Nahum J. Winer
Journal: Annals of Internal Medicine (1970)

Meeting Abstracts1 May 1970High-Frequency Direct Body Ballistocardiography: A New Concept.Nahum J. Winer, M.D., F.A.C.P.Nahum J. Winer, M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-72-5-777_3 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe clinical application of ballistocardiography to the study of heart disease has to date been elusive. Recent studies with high-frequency (acceleration) direct body ballistocardiography interpreted in terms of the second derivative of the carotid pulse and its own further differential have sharply delineated and reoriented the component forces of early (HI) and later (IJK) systolic phases.The theory proposed is that the normal "synergic" heart contracts with optimal acceleration maintaining the integrity of the HI and J waves, whereas acceleration of the "asynergic" heart is diminished even in the presence of minimal focal injury dominantly reflected in the diminished early... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: New York, N.Y. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 May 1970Volume 72, Issue 5Page: 777-777KeywordsCardiovascular therapyHeartHeart rateLongitudinal studies Issue Published: 1 May 1970 PDF downloadLoading ...
Abstract 5102: Identifying targets for melanoma therapy: Biological and clinical implications of BRAF L597 mutants
Authors: Kimberly Brown Dahlman, Junfeng Xia, Katherine Hutchinson, Donald Hucks, Peilin Jia, Zengliu Su, Donna J. Hicks, James L. Netterville, Cindy L. Vnencak-Jones, Jeffrey Sosman, Zhongming Zhao, William Pao
Journal: Cancer Research (2012)

Abstract Recurrent driver mutations in BRAF (V600), NRAS (G12/13, Q61), KIT (W557, V559, L576, K642, D816), GNAQ (Q209) and GNA11 (Q209) have previously been identified in malignant melanomas, but over one-third of cases have no known potentially actionable targets. To identify novel drivers, we performed whole-genome sequencing of a tumor-normal pair from a patient with an aggressive, chemotherapy-naïve metastatic melanoma which was pan-negative for the mutations listed above. Our data analysis pipeline revealed the landscape of somatic single nucleotide polymorphisms (SNPs), insertions and deletions, copy number variations, and structural variants. A subset of the nonsynonymous SNPs was validated by direct sequencing, resulting in the identification of a somatic BRAF L597R mutation. Surrogate kinase assays suggest that this mutant is sensitive to both BRAF and MEK inhibitors. Subsequent mutational analyses showed that BRAF L597 mutations were in 2 of 34 (6%) ‘pan-negative’ tumors. Collectively, these data demonstrate the frequency and potential therapeutic implications of BRAF L597 mutations in melanoma. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 103rd Annual Meeting of the American Association for Cancer Research; 2012 Mar 31-Apr 4; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2012;72(8 Suppl):Abstract nr 5102. doi:1538-7445.AM2012-5102
Factors that drive variation among gut microbial communities
Authors: Andrew H Moeller, Howard Ochman
Journal: Gut Microbes (2013)

Surveys of humans from around the world have revealed differences in gut microbiota composition among geographically separated populations. But because humans from the same regions often share common ancestry as well as dietary and cultural habits, most studies have not been able to differentiate among the effects of heritable factors and external factors on the composition of the gut microbiota. Here we discuss how the analysis of gut microbial communities of chimpanzees residing in Gombe Stream National Park has provided an unprecedented opportunity to measure the effects of external factors while controlling for heritable factors. The differences in gut microbiota composition between separated host populations of chimpanzees are due almost entirely to external factors, with the contribution of heritable factors to intraspecific variation in gut microbiota composition being too small to detect. The dominant influence of external factors in generating differences among the gut microbiota of our closest relatives lends promise to the possibility of manipulating the composition of the gut microbiome within human hosts. These results highlight the need for controlled studies that isolate the roles of specific external factors, such as diet, cultural practices and geography, in generating differences in the gut microbiota composition.
Are fetal brain tissue grafts necessary for the treatment of brain damage?
Authors: Donald G. Stein, Marylou M. Glasier
Journal: Behavioral and Brain Sciences (1995)

Abstract Despite some clinical promise, using fetal transplants for degenerative and traumatic brain injury remains controversial and a number of issues need further attention. This response reexamines a number of questions. Issues addressed include: temporal factors relating to neural grafting, the role of behavioral experience in graft outcome, and the relationship of rebuilding of neural circuitry to functional recovery. Also discussed are organization and type of transplanted tissue, the “trophic hypothesis” of transplant viability, and whether transplants are really needed to obtain functional recovery after brain damage.
THE FREQUENCY OF RICKETS IN INFANCY IN BOSTON AND VICINITY.
Authors: JOHN LOVETT MORSE
Journal: JAMA (1900)

My attention was directed to this subject by the apparent frequency with which a rosary was met with in the routine examination of infants. There seemed to be but two explanations for this frequency—either rickets was much more common in infancy in this vicinity than was commonly supposed, or else a rosary was normal and not an evidence of this disease. In order, if possible, to answer these questions, 400 infants under 2 years of age were examined in the medical out-patient department of the Infants' Hospital, during June and July, 1898, for evidences of rickets. The majority of these children came from the more densely populated districts of Boston, Cambridge and Somerville; the rest from other parts of these cities and from the neighboring towns. The hygienic conditions of their homes were probably often of the worst, usually bad and rarely good. These 400 cases were consecutive, none being
Omeprazole for acute upper gastrointestinal bleeding.
Authors: J. H. Baron
Journal: BMJ (1992)

design features.Case matching is a more reliable fatality rates in this particular trial) must reflect the dose, defined as the amount needed to produce the means of eliminating errors than comparing the probability that the result was simply due to required effect.study group with a control group of a different size mismatching.The gastric acid outputs or acidities of the as in Hinton's survey.
TWO EXPERIMENTS IN RESTORING LOST SPEECH, OR PARTIAL RESTORATION OF SPEECH BY SYSTEMATIC EDUCATION.
Authors: L. PIERCE CLARK
Journal: JAMA (1896)

While reading one of Professor Sully's articles on Childhood, the thought occurred to me that, in many cases of aphasia in people suffering from apoplexy of the brain and also in the allied disorders of softening and actual breaking down of different portions of the brain, there existed a striking analogy between such attempting to acquire the language anew and the child's attempts in learning to speak for the first time. I recall two cases that give interesting and peculiar illustrations of this analogy. The first, a subject of right side paralysis, had been unable to speak at all, with the exception of the words, "gully" and "damn." The former she uses at all times and the latter only at periods when she becomes very much excited. This word "gully" she repeats three or four times in varying degrees of tone and pitch, as though each repetition of the word
Control of Experimental Inflammatory Bowel Disease by Regulatory T cells
Authors: CHRYSTELLE ASSEMAN, SANNA FOWLER, FIONA POWRIE
Journal: American Journal of Respiratory and Critical Care Medicine (2000)

Section:ChooseTop of pageAbstract <<REGULATORY T CELLS IN THE...REGULATORY CELLS IN SYSTE...ANTIGEN-INDUCED REGULATOR...DIFFERENTIATION OF REGULA...CONCLUDING REMARKSReferencesCITING ARTICLES
Inoculation and the Incubation Stage of Plague
Authors: W. B. Bannerman
Journal: BMJ (1901)

MEDICAL JOURNAL I pub- lished a preliminary note regarding the results of experiments with specific antiserums, a complete account of which appeared iR the Journal of Xygiene for July.As stated in the latter publication we had gone a step further than mentioned in the preliminary note, finding it possible to detect human blood, or any other blood for which we had prepared a test serum, when that blood had been mixed with five or six other bloods, each blood in the mixture being present in the pro- portion of i to 5oo or I to 6oo.In the papers above eited it was stated that 36 bloods had been tested.I have since tested 140 bloods, the result being consistent with what has been already described.The 140 bloods tested were derived from all classes of verte- brates.None except monkey bloods gave a reaction with the antiserum for human blood.The monkey bloods tested were the following: Family Cercopithecidw, Semnopithecus entullus (India), Cercopithecus Campbelli, Waterh.(W.Africa), C. patas (W.Africa), C. lalandi, Is.Geoffr.(S.Africa), C. diana (W.Africa), C. melogenys (W.Africa),
Dramatic Readings from Capitol Hill
Authors: Daniel S. Greenberg
Journal: New England Journal of Medicine (1976)

The present-day decline in the art of playwriting is a loss, but there is some compensation to be found in the verbatim catch provided by tape recorders and shorthand reporters.It is to tape that we owe our gratitude for a remarkable conversation that was recently revealed at a hearing of the Senate Finance Committee. The purpose of the hearing was to consider legislation designed to detect and prosecute fraud in the Medicaid and Medicare programs. Senator Frank E. Moss (D-Utah), who chairs a subcommittee that has uncovered serious abuses by physicians, appeared before his fellow senators to tell of . . .
FDA Funding Boost
Authors: Mike Mitka
Journal: JAMA (2008)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Increased synthesis and expression of H-2 antigens on thymocytes as a result of radiation leukemia virus infection: a possible mechanism for H-2 linked control of virus-induced neoplasia.
Authors: D Meruelo, S H Nimelstein, P P Jones, M Lieberman, H O McDevitt
Journal: The Journal of Experimental Medicine (1978)

Previous studies from this laboratory have mapped resistance and/or susceptibility to radiation-induced leukemia virus (RadLV)-induced neoplasia to the H-2D region. H-2 linked effects on virus replication can be detected subsequent to the initial virus infection, and clear-cut differences in numbers of virus infected thymus cells can be detected as early as 5 wk after RadLV inoculation. Rapid increases in cellular synthesis and cell surface expression of H-2 antigens are detectable immediately after virus inoculation. These changes have been studied by immunofluorescence, absorption, cell surface iodination followed by sodium dodecyl-sulfate-polyacrylamide gel electrophoresis, and two dimensional gel electrophoretic analysis of internally labeled lymphocyte proteins. Expression of H-2K molecules is significantly increased in cells of susceptible and resistant animals. However, significant increases in expression of H-2D antigens occurs only on thymus cells from resistant strains (H-2Dd). Transformed cells of resistant and susceptible H-2 haplotypes adapted to tissue culture lack detectable H-2 antigens as determined by serological absorption studies. It is argued that altered expression of H-2 antigens plays a very significant role in the mechanism of host defense to virus infection.
603 Insulin resistance in co-infected HCV/HIV patients: A negative factor influencing sustained response to peginterferon plus ribavirin
Authors: M. Romero-Gomez, C. Tural, R. Sola, M.C. Martinez-Sierra, M.M. Viloria, M.D. Jimenez, A. Arizcorreta, C. Trabadela, B. Clotet, R. Planas
Journal: Journal of Hepatology (2006)
Imported syringes triggered meningitis in Sri Lanka
Authors: Ganapati Mudur
Journal: BMJ (2005)

Health authorities in Sri Lanka have said that imported injection syringes might have triggered an outbreak of meningitis in patients who had received spinal anaesthesia in four hospitals in the country.

Two maternity and two teaching hospitals reported 14 cases of meningitis associated with spinal anaesthesia or other procedures, such as lumbar puncture, during a three week period last month, government epidemiologists said. Four of the patients have died.

Investigations indicate that contaminated syringes and needles might have caused …
234 Percutaneous radiofrequency thermal ablation (RFTA) of small hepatocellular carcinoma: A prospective study
Authors: C. Camma, V. Di Marco, A. Orlando, L. Sandonato, P. Parisi, E. Sciarrino, R. Virdone, A. Casaril, D. Cabibi, S. Pardo, D. Di Bona, S. Alizzi, G. Montalto, M.A. Latteri, N. Nicoli, A. Craxi
Journal: Journal of Hepatology (2004)
African countries need to allocate more of their budgets to health, says WHO
Authors: J. Zarocostas
Journal: BMJ (2011)

Many African governments are not allocating enough funds from their annual budgets to health, says a study by the World Health Organization. Without additional resources, vital health goals will not be achieved, it says.

In the 10 years since heads of state of African Union countries met in Abuja, Nigeria, and pledged to set a target of allocating “at least 15%” of their annual budget to improve the health sector, only Rwanda and South Africa have reached the objective, says WHO.

Overall, WHO says, 27 countries have increased …
GROWTH OF FIBROBLASTS AND HYDROGEN ION CONCENTRATION OF THE MEDIUM
Authors: Albert Fischer
Journal: The Journal of Experimental Medicine (1921)

1. The rate of growth of fibroblasts is markedly modified by slight changes in the hydrogen ion concentration of the medium. The curves expressing the rate of growth in function of the hydrogen ion concentration of the medium are nearly symmetrical on both sides of the maximum. 2. The optimum growth of fibroblasts occurs at pH 7.4 to 7.8. A slight change from this reaction has a remarkable influence on the rate of growth. 3. Fibroblasts show more resistance to higher alkalinity than to higher acidity. They grew for only four to six generations in a medium having a pH of 5.5, and for more than ten generations in one of 8.5. 4. The influence of different hydrogen ion concentrations on fibroblasts was only of a quantitative nature.
Learning Accountability for Patient Outcomes
Authors: Peter J. Pronovost
Journal: JAMA (2010)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
An Unusual Case of Gallbladder Cancer in an Automotive Worker
Authors: P. W. Brandt-Rauf, A. W. Branwood
Journal: CA A Cancer Journal for Clinicians (1980)

Mucinous adenocarcinoma of the gallbladder was found at autopsy in a 65-year-old male. The tumor was composed predominantly of signet ring cells, an uncommon histologic form. In addition, there was an atypical pattern of metastasis, with cancer involving not only the walls of the cystic duct, large and small bowels, peritoneum, abdominal nodes, and omentum, but also the kidneys, ureters, lungs, and heart. Although the patient lacked the common predisposing factors for gallbladder cancer, he did work in an industry with a significant relative risk for the development of this cancer.
Health promotion by encouraged use of stairs
Authors: A. Blamey, N. Mutrie, T. Aitchison
Journal: BMJ (1995)

The national fitness survey for England concluded: “the high prevalence of physical inactivity suggests that it may be even more important for public health than attention to cholesterol, arterial blood pressure or smoking.”1 The prevalence and risk of inactivity in the United States led the American College of Sports Medicine to issue guidelines suggesting that sedentary adults should have at least 30 minutes of accumulated moderate physical activity on most days of the week.2 To achieve this target the members of the public should be encouraged to add activity into their daily routine at every opportunity.

This study investigated whether Scottish commuters or shoppers would respond to an intervention consisting of motivational signs encouraging them to walk up stairs rather than take an escalator.

Signs saying “Stay Healthy, Save Time, Use the Stairs” were placed …
Interpersonal Predictors of HbA1c in Patients With Type 1 Diabetes
Authors: Paul S. Ciechanowski, Irl B. Hirsch, Wayne J. Katon
Journal: Diabetes Care (2002)

OBJECTIVE—Research suggests that increased collaboration and satisfaction in the patient-provider relationship is associated with better outcomes in patients with diabetes. In adults, an interpersonal style characterized by low trust of others and excessive self-reliance is known as “dismissing attachment style.” We hypothesized that diabetic patients with dismissing attachment style, due to a decreased ability to collaborate with providers and others, would have significantly higher HbA1c levels than patients with secure attachment style. RESEARCH DESIGN AND METHODS—From 276 adult tertiary care patients with type 1 diabetes, we obtained mean HbA1c levels over the prior year and assessed patient attachment style, demographics, and clinical characteristics. We used χ2 tests and logistic regression to determine whether attachment style was associated with HbA1c levels. RESULTS—We found that 62% of patients with dismissing attachment style had mean HbA1c levels ≥8% compared with 34% of patients with secure attachment style (P = 0.002). After adjusting for demographics, diabetes severity, medical comorbidity, and depression, dismissing attachment style remained significantly associated with HbA1c levels ≥8%, compared with secure attachment style (odds ratio 2.5, 95% CI 1.1–6.0). CONCLUSIONS—We have found that dismissing attachment style is associated with a higher risk for poor glycemic control. This has relevance from a population-based perspective because ∼25% of the general population has a dismissing attachment style. Attachment style is easily measured using self-report instruments and may inform clinicians how to work with patients who are less engaged in the health care relationship.
Prescribing of lipid lowering drugs to South Asian patients: ecological study
Authors: M. G Patel
Journal: BMJ (2002)

Coronary heart disease is the major cause of morbidity and mortality in the South Asian population in the United Kingdom, and its incidence is higher than in the white population.1 This excess risk seems to be determined by a combination of metabolic factors leading to the insulin resistance syndrome, psychosocial factors, and established risk factors.2 Ten out of 15 coronary risk factors measured were reported to be higher in South Asian patients than in their European counterparts, and several of these factors are believed to reflect relative deprivation. South Asian people are also at risk owing to high triglyceride concentrations and low concentrations of high density lipoprotein cholesterol. Although substantial evidence shows the value of lowering cholesterol in people at risk, studies have shown that many patients are not receiving appropriate treatment.3 We investigated the relation …