Antilymphocyte Serum as an Immunosuppressive Agent
Authors: PAUL S. RUSSELL
Journal: Annals of Internal Medicine (1968)

Editorials1 February 1968Antilymphocyte Serum as an Immunosuppressive AgentPAUL S. RUSSELL, M.D.PAUL S. RUSSELL, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-68-2-483 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe control of immunological responses has become more significant as we have become more aware of their importance in many disease processes. This is true especially in regard to the rising use of tissue transplantation as a form of treatment. Current methods, in which a variety of cytotoxic agents are employed, have had the major drawback of being quite nonspecific with the result that the body's defenses against invading organisms may be dangerously lowered (1). In spite of the potency of available drugs, their effects, at safe dosages, are not infrequently overridden by advancing rejection reactions. Better methods of selecting...References1. RUSSELL PS: Tissue immunity and organ transplantation. 1st American Urological Association Lecture, October 5, 1967. Surg. Gynec. Obstet. In press. Google Scholar2. BARNES BA, MURRAY JE, and ATKINSON J: Data from the kidney transplant registry: survival of secondary renal transplants and an analysis of early renal function. Proceedings of the 1st International Congress of the Transplantation Society, Munksgaard, Copenhagen. In preparation. Google Scholar3. WOLSTENHOLME GE and O'CONNOR M Antilymphocytic Serum. Ciba Foundation Study Group No. 29. edited by J. & A. Churchill, Ltd., London, 1967, 165 pages. Google Scholar4. RUSSELL PS and MONACO AP: Heterologous antilymphocytic sera and some of their effects. Transplantation 5: 1086, 1967. CrossrefGoogle Scholar5. MONACO AP, WOOD ML, VAN DER WERF BA, and RUSSELL PS: Effects of antilymphocytic serum in mice, dogs and man, in Antilymphocytic Serum. Ciba Foundation Study Group. No. 29. edited by WOLSTENHOLME, G. E., O'CONNOR, M. J. & A. Churchill, Ltd., London, 1967, pp. 111-134. Google Scholar6. MONACO AP, ABBOTT WN, OTHERSEN HB, SIMMONS RL, WOOD ML, FLAX MH, and RUSSELL PS: Antiserum to lymphocytes; prolonged survival of canine renal allografts. Science 153: 1264, 1966. CrossrefMedlineGoogle Scholar7. KASHIWAGI N, BRANTIGAN CO, BRETTSCHNEIDER L, GROTH CG, and STARZL TE: Clinical reactions and serologic changes after the administration of heterologous antilymphocyte globulin to human recipients of renal homografts. Ann. Intern. Med. 68: 275, 1968. LinkGoogle Scholar8. JEEJEEBHOY HH: Studies on the mode of action of heterologous antilymphocyte plasma. I. A comparison of the immunosuppressive properties of dog and rabbit anti-rat lymphocyte plasma. Transplantation 5: 273, 1967. CrossrefGoogle Scholar9. LEVEY RH and MEDAWAR PB: Nature and mode of action of antilymphocytic antiserum. Proc. Nat. Acad. Sci. U. S. A. 56: 1130, 1966. CrossrefMedlineGoogle Scholar10. VAN DER WERF BA, MONACO AP, WOOD ML, and RUSSELL PS: Immune competence of mouse cells after in vivo and in vitro contact with RAMLS, in Proceedings of the 1st International Congress of the Transplantation Society, Munksgaard, Copenhagen. In press. Google Scholar11. BATCHELOR JR: Personal communication; McIndoe Research Unit. Google Scholar12. MORRIS PJ, BONDOC C, and BURKE JF: Effect of heterologous antilymphocyte serum on acute bacterial inflammation. Surg. Forum 18: 74, 1966. Google Scholar13. STARZL TE, PORTER KA, IWASAKI Y, MARCHIORO TL, and KASHIWAGI N: The use of heterologous antilymphocyte globulin in human renal homotransplantation, in Antilymphocytic Serum. Ciba Foundation Study Group No. 29. J. & A. Churchill, Ltd., London, 1967, pp. 4-34. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: PAUL S. RUSSELL, M.D.Affiliations: General Surgical Services Massachusetts General Hospital Boston, Mass. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byFive years’ experience with thymoglobulin induction in a pediatric renal transplant populationSelective renal venography in patients with primary renal disease and the nephrotic syndromeAntilymphocyte SerumSuppression of the immune response.Antilymphocyte serum blockade of the reticuloendothelial systemTransplantationExperimental Acute and Chronic Viral HepatitisImmunological Aspects of Renal AllotransplantationThe effect of heterologous Anti-Lymphocyte serum on Delayed-Type hypersensitivity in miceAntilymphocytic Antibody: Effects in Experimental Animals and Problems in Human UseSTEWART SELL, M.D.Transplantation in the FutureANTILYMPHOCYTE SERUM: A REVIEW WITH REPORT OF THE CURRENT CLINICAL SITUATION IN AUSTRALIAHeart transplantation: Some general remarksChapter 21. Non-steroidal Anti-inflammatory Agents 1 February 1968Volume 68, Issue 2Page: 483-486KeywordsCytotoxinsDrugsImmunosuppressivesTransplantation ePublished: 1 December 2008 Issue Published: 1 February 1968 PDF downloadLoading ...