tbuckley/cabot-search huggingface dataset:
Psychotic disorders in DSM-III-R
Authors: K S Kendler, R L Spitzer, J B Williams
Journal: American Journal of Psychiatry (1989)

The authors review the important changes in the three sections of DSM-III-R that include only psychotic disorders (schizophrenia, delusional disorder, and psychotic disorders not elsewhere classified), outline the rationale for these changes, and, where available, review their empirical basis. In addition, they review two proposed changes that were not incorporated into DSM-III-R. They conclude by calling for an increasingly rigorous and data-based process of nosologic revision.
Bifurcation Coronary Lesions Treated With the “Crush” Technique
Authors: Ricardo A. Costa, Gary S. Mintz, Stephane G. Carlier, Alexandra J. Lansky, Issam Moussa, Kenichi Fujii, Hideo Takebayashi, Takenori Yasuda, Jose R. Costa, Yoshihiro Tsuchiya, Lisette O. Jensen, Ecaterina Cristea, Roxana Mehran, George D. Dangas, Sriram Iyer, Michael Collins, Edward M. Kreps, Antonio Colombo, Gregg W. Stone, Martin B. Leon, Jeffrey W. Moses
Journal: Journal of the American College of Cardiology (2005)
Malaria knowledge, attitudes and practices among migrants from malaria-endemic countries in Evrotas, Laconia, Greece, 2013
Authors: Iro Evlampidou, Kostas Danis, Annick Lenglet, Maria Tseroni, Yorgos Theocharopoulos, Takis Panagiotopoulos
Journal: Eurosurveillance (2015)

Following re-emergence of malaria in Evrotas, Laconia, in 2009–12, a malaria-control programme was implemented in 2011–12 targeting migrants from malaria-endemic countries, including house-to-house active case detection, health education and distribution of mosquito protection items. In June 2013, we surveyed migrants in Evrotas to assess their malaria knowledge, attitudes and practices to guide prevention activities. We selected participants using simple random sampling and interviewed them, using structured questionnaires. We defined mosquito protection practices (MPPs) as the use of full-length clothes/topical repellent, mosquito screens, fans or air-conditioning, and insecticides. We calculated prevalence ratios (PRs) using Poisson regression and we allowed for clustering of participants in a residence. Of 654 migrants, we invited 132 and 130 participated (all men; 120 (92%) from Pakistan). Of the 130, 56 (43%) identified fever as a malaria symptom; those who were aware of this had higher level of education (PR: 3.2; 95% confidence interval (CI): 1.2–9.0). A total of 111 (85%) used insecticide-treated bednets and 95 (73%) used more than two MPPs. Poor housing conditions (warehouses/shacks: PR: 0.8; 95% CI: 0.6–0.9), were associated with use of up to two MPPs. Despite extensive interventions in Evrotas, the level of malaria awareness among migrants remained suboptimal and poor housing conditions hindered effective mosquito protection. We recommend culturally adapted health education and improvement of housing conditions to minimise the risk of new cases and re-establishment of malaria in Greece.
Prognostic Value of Numerical Chromosome Aberrations in Multiple Myeloma: A FISH Analysis of 15 Different Chromosomes
Authors: J.A. Pérez-Simón, R. Garcı́a-Sanz, M.D. Tabernero, J. Almeida, M. González, J. Fernández-Calvo, M.J. Moro, J.M. Hernández, J.F. San Miguel, A. Orfão
Journal: Blood (1998)
Abstract 15508: Detection and Therapy of Ischemia-Reperfusion Injury Using Hydrogen Peroxide-Activatable Polyoxalate Nanoparticles
Authors: Dongwon Lee, Soochan Bae, Qingen Ke, Byung J Son, Ji Y Lee, S A Karumanchi, Haksoo Choi, Peter M Kang
Journal: Circulation (2011)

The main culprit in the pathogenesis of ischemia/reperfusion (I/R) injury is the generation of high level of hydrogen peroxide (H2O2), which causes apoptosis and inflammation leading to cellular da...
Abstract 21325: Is Retention of the Presynaptic Sympathetic Nerve Function Probe, [11C] Hydroxyephedrine, Related to Myocardial Blood Flow in Non-Ischemic Cardiomyopathy?
Authors: Maria C Ziadi, Albert Swedani, Robert A deKemp, Ann Guo, Ian G Burwash, Haissam Haddad, Lisa M Mielniczuk, Olga Walter, John S Floras, Rob S Beanlands
Journal: Circulation (2010)

Introduction:  Impaired cardiac presynaptic sympathetic nervous (SN) function measured using meta-iodobenzylguanidine (MIBG) or [ 11 C] hydroxyephedrine (HED) PET has been identified as a prognostic indicator in patients with heart failure (HF). Reperfusion studies in animals have suggested that HED retention is dependent on perfusion. However, it is unclear whether the same principle applies to patients with non-ischemic cardiomyopathy (NICM). We sought to determine whether there is a relationship between [ 11 C] hydroxyephedrine (HED) retention and resting myocardial blood flow (MBF) - measured with [ 11 C] acetate kinetics, which would have implications for HED retention as a parameter for measuring SN function.   Methods:  We prospectively evaluated 18 HF patients with chronic stable NICM (left ventricular ejection fraction (LVEF) ≤ 40% and New York Heart Association (NYHA) class ≥ II). Global myocardial presynaptic SN function was quantified using HED PET uptake and retention. Rest MBF was assessed with [ 11 C] acetate PET time-activity data using a one-compartment model.   Results:  For the 18 patients [mean age 61 yrs (±11), 55% male, 83% NYHA class II), mean LVEF was 32% (±6) and 71% had obstructive sleep apnea. Global HED retention was related to LVEF (r=0.41, p=0.09) and also significantly correlated with [ 11 C] acetate MBF at rest (r=0.85 p=   Conclusions:  Myocardial retention of HED is significantly dependent on MBF in patients with NICM. This data underscores the importance of parallel MBF measurements and correction of HED retention for flow to ensure accurate interpretation of neuronal imaging PET studies in HF populations. This relationship could impact the prognostic value of presynaptic SN function probes and requires further study.
Abstract 2884: Elevated Postoperative Cardiac Troponin I Levels Independently Predict Higher Long-Term Morbidity and Mortality Following Off-Pump CABG
Authors: Ismail El-Hamamsy, Louis M Stevens, Raymond Cartier
Journal: Circulation (2007)

Background- Cardiac enzyme elevations after CABG are frequent, but little is known about the long-term outcomes of patients. The aims of the present study were to evaluate the prognostic significance of postoperative cTnI and CK-MB elevations on long-term morbidity and mortality following off-pump CABG. Methods- Between 1996 and 2004, 1004 consecutive off-pump CABG procedures were performed. Major adverse cardiac events (MACE) were defined as cardiac death or death of unknown cause, myocardial infarction, repeat revascularization and recurring angina. Mean length of follow-up was 4.6 ± 1.9 years (up to 9 years). Follow-up was 100% complete. Time-specific effects were estimated using parametric multiphase hazard regression. Results- Elevated cTnI (&gt;0.3 ng/mL) and CK-MB (&gt;50 ng/mL) were observed in 166/719 (23%) and 85/1001 (8%) of patients, respectively. Thirty-day mortality was 1.8%. The incidence of perioperative myocardial infarction was 2%. Overall 8-year survival was 71 ± 3% and cardiac survival was 93 ± 1%. Long-term mortality was independently predicted by cTnI ( p &lt; .001 , respectively; see figure ), but not by CK-MB ( p &gt; .05 ). Long-term incidence of MACE was independently predicted by postoperative cTnI ( p = 0.02 ), not by CKMB ( p &gt; .05 ). MACE-free survival at 5 years ranged from 86 ± 3% for the lowest cTnI quartile to 69 ± 4% in the highest ( p &lt; .001 ). Conclusion- Postoperative levels of cTnI bear significant prognostic value on long-term morbidity and mortality following off-pump CABG. cTnI is a more sensitive marker of long-term outcomes than CK-MB. Patients with mild cTnI elevations after CABG should be closely followed up despite an uneventful postoperative recovery.
HIV risk behaviour knowledge, substance use and unprotected sex in men who have sex with men in Tallinn, Estonia
Authors: A Tripathi, K Rüütel, R D Parker
Journal: Eurosurveillance (2009)

This study examines HIV risk behaviour knowledge, substance use and unprotected sex in a sample of 79 men who have sex with men (MSM) in Tallinn, Estonia. Median age of the study population was 30 years (range 18-62 years); 35 were bisexual; 56 answered correctly to at least 10 out of 13 questions about HIV risk behaviours; 23 consumed more than seven alcoholic drinks in the week before the survey; nearly half (n=34) of the participants reported some illicit drug use in the past 12 months; 40 did not use a condom regularly in the 12 months preceding the survey, and 41 did not use a condom during their last sexual intercourse. Alcohol consumption in the week before the survey was negatively associated with condom use during last intercourse (RR 0.48; 95% CI 0.41-0.56). Use of illicit drugs varied significantly by ethnicity (p-value = 0.02). Multivariable analysis showed that higher consumption of alcohol in the week before the survey could be predicted by education, age group and sexual orientation. In conclusion, socio-demographic factors such as education, age, ethnicity and sexual orientation may affect HIV risk behaviour knowledge, sexual behavior and substance use among MSM in Estonia, and need to be taken into consideration for targeted HIV prevention.
Abstract 8712: Anticoagulation-Associated Adverse Drug Events
Authors: Gregory Piazza, Thanh N Nguyen, Deborah Cios, Matthew Labreche, Benjamin Hohlfelder, John Fanikos, Karen Fiumara, Samuel Z Goldhaber
Journal: Circulation (2011)

Introduction: Anticoagulant drugs are among the most common medications that cause adverse drug events (ADEs) in hospitalized patients. Hypothesis: We assessed the hypothesis that anticoagulant-associated ADEs are preventable sources of morbidity, mortality, and increased hospitalization costs. Methods: We reviewed all inpatient anticoagulant-associated ADEs, including adverse drug reactions (ADRs) and medication errors (MEs), reported at Brigham and Women's Hospital through the Safety Reporting System from May 2004 to May 2009. We also collected data regarding the cost associated with hospitalizations in which ADRs occurred. Results: Of 463 anticoagulant-associated ADEs, 226 were MEs (48.8%), 141 were ADRs (30.5%), and 96 (20.7%) involved both an ME and ADR. Patients who suffered anticoagulant-associated ADEs had a median length of stay of 13 days and a high rate of re-hospitalization within 30 days of the ADE (17.5%). Seventy percent of anticoagulant-associated ADEs were preventable. Transcription errors (48%) were the most frequent root cause of anticoagulant-associated MEs, while MEs were the most common root cause of anticoagulant-associated ADRs (40%). Death within 30 days of anticoagulant-associated ADEs occurred in 11% of patients. After an anticoagulant-associated ADR, most hospitalization expenditures were attributable to nursing costs (mean $33,189 per ADR) followed by pharmacy costs (mean $7,451 per ADR). Conclusion: Most anticoagulant-associated ADEs among inpatients are due to MEs and are therefore preventable. We observed an increased 30-day mortality rate among patients who suffered an anticoagulant-associated ADE and high hospitalization costs following ADRs. Further Quality Improvement efforts to reduce anticoagulant-associated MEs are warranted to improve patient safety and decrease health care expenditures.
Present use of bedside right heart catheterization in patients with cardiac disease11This Expert Consensus Document was approved by the American College of Cardiology Board of Trustees in March 1998.22Address for reprints: Educational Services, American College of Cardiology, 9111 Old Georgetown Road, Bethesda, Maryland 20814-1699.
Authors: HiltrudS Mueller, Kanu Chatterjee, KathrynB Davis, MichaelA Fifer, Cory Franklin, MarkA Greenberg, ArthurJ Labovitz, PredimanK Shah, KennethJ Tuman, MaxHarry Weil, WilliamS Weintraub, JamesS Forrester, PamelaS Douglas, DavidP Faxon, JohnD Fisher, RaymondJ Gibbons, JonathanL Halperin, JudithS Hochman, AdolphM Hutter, Sanjiv Kaul, WilliamS Weintraub, WilliamL Winters, MichaelJ Wolk
Journal: Journal of the American College of Cardiology (1998)
A human antibody directed to the factor VIII C1 domain inhibits factor VIII cofactor activity and binding to von Willebrand factor
Authors: Marc Jacquemin, Abdellah Benhida, Kathelijne Peerlinck, Benoı̂t Desqueper, Luc Vander Elst, Renaud Lavend'homme, Roseline d'Oiron, Rainer Schwaab, Marleen Bakkus, Kris Thielemans, Jean-Guy Gilles, Jos Vermylen, Jean-Marie Saint-Remy
Journal: Blood (2000)
To Err Is Human
Authors: Joseph L Halbach, Laurie Sullivan
Journal: JAMA (2005)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Marijuana use in schizophrenia: a clear hazard
Authors: D A Treffert
Journal: American Journal of Psychiatry (1978)

The use of marijuana as the independent variable produced a serious exacerbation of a psychotic process in four schizophrenic patients whose illness was otherwise well controlled with antipsychotic medication. Each patient served as his own control--the sole substance abused was marijuana and antipsychotic medication intake remained constant. Each time marijuana use at moderate levels began, there was exacerbation and deterioration. The author suggests that marijuana use is a special hazard to schizophrenic patients and that physicians should alert such high-risk patients to the possible untoward interaction between their illness and marijuana.
Atrial Fibrillation Begets Atrial Fibrillation in the Pulmonary Veins
Authors: Thomas Rostock, Daniel Steven, Boris Lutomsky, Helge Servatius, Imke Drewitz, Hanno Klemm, Kai Müllerleile, Rodolfo Ventura, Thomas Meinertz, Stephan Willems
Journal: Journal of the American College of Cardiology (2008)
Prenatal Ambient Air Pollution, Placental Mitochondrial DNA Content, and Birth Weight in the INMA (Spain) and ENVIR <i>ON</i> AGE (Belgium) Birth Cohorts
Authors: Diana B.P. Clemente, Maribel Casas, Nadia Vilahur, Haizea Begiristain, Mariona Bustamante, Anne-Elie Carsin, Mariana F. Fernández, Frans Fierens, Wilfried Gyselaers, Carmen Iñiguez, Bram G. Janssen, Wouter Lefebvre, Sabrina Llop, Nicolás Olea, Marie Pedersen, Nicky Pieters, Loreto Santa Marina, Ana Souto, Adonina Tardón, Charlotte Vanpoucke, Martine Vrijheid, Jordi Sunyer, Tim S. Nawrot
Journal: Environmental Health Perspectives (2015)

Mitochondria are sensitive to environmental toxicants due to their lack of repair capacity. Changes in mitochondrial DNA (mtDNA) content may represent a biologically relevant intermediate outcome in mechanisms linking air pollution and fetal growth restriction.We investigated whether placental mtDNA content is a possible mediator of the association between prenatal nitrogen dioxide (NO2) exposure and birth weight.We used data from two independent European cohorts: INMA (n = 376; Spain) and ENVIRONAGE (n = 550; Belgium). Relative placental mtDNA content was determined as the ratio of two mitochondrial genes (MT-ND1 and MTF3212/R3319) to two control genes (RPLP0 and ACTB). Effect estimates for individual cohorts and the pooled data set were calculated using multiple linear regression and mixed models. We also performed a mediation analysis.Pooled estimates indicated that a 10-μg/m3 increment in average NO2 exposure during pregnancy was associated with a 4.9% decrease in placental mtDNA content (95% CI: -9.3, -0.3%) and a 48-g decrease (95% CI: -87, -9 g) in birth weight. However, the association with birth weight was significant for INMA (-66 g; 95% CI: -111, -23 g) but not for ENVIRONAGE (-20 g; 95% CI: -101, 62 g). Placental mtDNA content was associated with significantly higher mean birth weight (pooled analysis, interquartile range increase: 140 g; 95% CI: 43, 237 g). Mediation analysis estimates, which were derived for the INMA cohort only, suggested that 10% (95% CI: 6.6, 13.0 g) of the association between prenatal NO2 and birth weight was mediated by changes in placental mtDNA content.Our results suggest that mtDNA content can be one of the potential mediators of the association between prenatal air pollution exposure and birth weight.Clemente DB, Casas M, Vilahur N, Begiristain H, Bustamante M, Carsin AE, Fernández MF, Fierens F, Gyselaers W, Iñiguez C, Janssen BG, Lefebvre W, Llop S, Olea N, Pedersen M, Pieters N, Santa Marina L, Souto A, Tardón A, Vanpoucke C, Vrijheid M, Sunyer J, Nawrot TS. 2016. Prenatal ambient air pollution, placental mitochondrial DNA content, and birth weight in the INMA (Spain) and ENVIRONAGE (Belgium) birth cohorts. Environ Health Perspect 124:659-665; http://dx.doi.org/10.1289/ehp.1408981.
Abstract 16396: Glucose-6-Phosphate Dehydrogenase Deficiency Promotes Susceptibility to Pressure Overload Induced Left Ventricular Dysfunction and Hypertrophy
Authors: Peter A Hecker, Rogerio F Ribeiro, Bethany H Brown, Kelly O'Connell, William C Stanley
Journal: Circulation (2011)

Glucose-6-phosphate dehydrogenase (G6PD) deficiency is the most common enzymopathy in the world, is highly prevelant in Africans, and has been associated with either increased or reduced risk for c...
Abstract 261: Intentional or Inadvertent Hyperventilation of Patients with Out-of-Hospital Cardiac Arrest on Hospital Arrival
Authors: Eric Helfenbein, Reza Firoozabadi, Saeed Babaeizadeh, Mohamud Daya
Journal: Circulation (2012)

Background The deleterious effects of intentional or inadvertent hyperventilation of out-of-hospital cardiac arrest (OHCA) patients include decreased venous blood return, increased intracranial pressure and decreased coronary perfusion pressure. Recent AHA guidelines specify ventilation rates between 8-12 breaths per minute (bpm). We previously presented findings that hyperventilation is common immediately following placement of an airway device. We also observed a number of cases in which hyperventilation occurred close to the end of recordings from EMS monitor-defibrillators presumably corresponding to the time of hospital arrival and transfer of care. Objective Determine the prevalence of intentional or inadvertent hyperventilation of OHCA patients upon hospital arrival and transfer of care to hospital staff. Methods Capnogram recordings from a convenience sample of 205 OHCA patients collected between 2006 to 2010 from a single EMS agency using Philips HeartStart MRx defibrillators were examined. An automated breath detection algorithm that relied on capnographic waveforms was used to compute ventilation rates and EtCO2 levels. Clinical charts written by the EMS personnel were examined to determine cardiac rhythm and if spontaneous breathing was observed upon hospital arrival, which was excluded. Results 23 cases (11.2%) were identified which were determined to have an episode of hyperventilation at the end of the recordings, with times corresponding to transfer of care after hospital arrival. Running average hyperventilation rates were 28±8 bpm, with average peak instantaneous rate 36±10 bpm, range 24-46 bpm. Average minimum EtCO2 during hyperventilation was 12±14 mmHg, range 1.8-70 mmHg. Conclusion Intentional or inadvertent hyperventilation of OHCA patients at rates well above AHA guidelines was present in 11% of cases at times corresponding to transfer of care from EMS to hospital staff. It is unclear if this was performed by EMS staff or hospital staff. Better awareness and communication of this potentially harmful behavior to EMS personnel and hospital staff is warranted.
Confidentiality and “Jambo, Jahi”—Reply
Authors: Claire Panosian Dunavan
Journal: JAMA (2005)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Abstract 1360: Vegetarian Dietary Pattern and Systolic Blood Pressure: Results From the Adventist Health Study 2 (AHS-2)
Authors: Ramtin Anousheh, Betty Pettersen, Gary Fraser
Journal: Circulation (2009)

Objective: To study how vegetarian dietary pattern influence systolic blood pressure(SBP) adjusting for well established risk factors for Hypertension(HTN). Background: Prior studies have suggested...