tbuckley/cabot-search huggingface dataset:
Evolution of Child Psychiatric Teamwork in a Somatic Hospital
Authors: Inger Helene Vandvik, Wencke J. Seltzer
Journal: Psychotherapy and Psychosomatics (1984)

This paper outlines the evolution of child psychiatric team work within the context of a general hospital. It focuses especially on the professional challenges and systemic problems arising during this 8 year long process. The question of what happens when two cultures meet in the same arena is discussed, and the process whereby a minority becomes a reality in a well-established majority system is described. Special attention is devoted to those principles appearing to play a major role in the evolutionary process. Prominent among these are: (1) operating within the already established; (2) transforming the 'ugly duckling into a swan', and (3) breaking into the established. The paper concludes with a brief discussion of the problems associated with maintaining enthusiasm in the team, scapegoating, and 'burn out'.
Hypersensitivity to lansoprazole and rabeprazole with tolerance to other proton pump inhibitors
Authors: A.J. Pérez Pimiento, L. Prieto Lastra, M.I. Rodríguez Cabreros, L.A. González Sánchez, M. Rodríguez Mosquera, A. García Cubero
Journal: Journal of Allergy and Clinical Immunology (2006)
Radiation Exposure to Radiologists With Eye Pathology
Authors: Gerhart S. Schwarz
Journal: JAMA (1979)

<h3>To the Editor.—</h3> I would like to comment on the inquiry by Irvin Deutsch, MD (242:372, 1979), in relation to "Irradiation Exposure Hazard to Radiologist With Existing Eye Pathology." As far as exposure for the radiologist to x-rays is concerned, all he need do is wear lead glass goggles during fluoroscopic examination; they reduce the incident radiation to practically zero. The more important factor, in my opinion, is the ultraviolet radiation emanating from standard view boxes. Ever since plastic diffusion panels came into use instead of glass, the ultraviolet light created by the fluorescent tubes strikes the observer. To avoid this, it is necessary for the radiologist to wear glass spectacles. The ordinary safety spectacles now mandated by law are made of plastic and do not absorb the ultraviolet rays. It is imperative that the radiologist use glass spectacles. They can be obtained by requesting safety<i>glasses</i>.
Exhaled nitric oxide as a marker for organic nitrate tolerance.
Authors: M Husain, C Adrie, F Ichinose, M Kavosi, W M Zapol
Journal: Circulation (1994)

BACKGROUND This study was designed to demonstrate the development of biochemical tolerance to organic nitrates by measuring levels of exhaled gaseous nitric oxide (NO) in lambs given intravenous (IV) nitroglycerin or sodium nitroprusside. METHODS AND RESULTS IV injections of nitroglycerin or sodium nitroprusside produced dose-dependent and sustained increases in the exhaled levels of nitric oxide measured by chemiluminescence in awake lambs with tracheostomies. After a 6-hour IV infusion of 25 micrograms.kg-1.min-1 nitroglycerin, peak exhaled NO levels were significantly reduced (-53.6 +/- 4.9%, mean +/- SEM, P &lt; .001) and systemic hypotensive responses were attenuated (-52.6 +/- 5.9%, P &lt; .001) after an IV challenge of nitroglycerin but not sodium nitroprusside. After a subsequent 12-hour nitroglycerin-free period, there was complete recovery of NO excretion in exhaled breath and a return to baseline of systemic hypotensive changes on administration of IV nitroglycerin boluses. For IV sodium nitroprusside challenges, pulmonary NO excretion and systemic hypotensive responses remained constant throughout the study. Challenges with IV nitroglycerin but not sodium nitroprusside during a 12-hour nitroglycerin-free period resulted in delayed biochemical recovery with various exhaled NO levels and systemic hypotensive responses to challenges with IV nitroglycerin. CONCLUSIONS Measurements of exhaled NO provide in vivo, noninvasive evidence for the development of biochemical tolerance to nitroglycerin. There was reduced NO release into exhaled gas from the pulmonary vasculature concomitant with evidence of tolerance to nitroglycerin vasodilation in the systemic circulation.
Recent Trends in Lung Cancer Mortality in the United States
Authors: A. Jemal, K. C. Chu, R. E. Tarone
Journal: JNCI Journal of the National Cancer Institute (2001)

Background: Previous age–period–cohort analyses of lung cancer incidence and mortality rates in the United States have demonstrated a decrease in risk by birth cohort through 1950, consistent with declining trends in smoking prevalence. This study was conducted to examine recent lung cancer trends, including trends among the cohorts born after 1950. Methods: Lung cancer mortality rates from 1970 through 1997 for whites aged 24–83 years and for blacks aged 30–83 years were investigated. Using age–period–cohort analyses with 2-year age and 2-year calendar-period intervals, we examined changes in the slope of the trends in birth-cohort and calendar-period effects. All statistical tests are two-sided. Results: There was an unexpected, statistically significant moderation in the rate of decrease of the birth-cohort trend in lung cancer mortality for whites born after 1950, with a corresponding smaller and statistically nonsignificant moderation for blacks. These data are consistent with smoking initiation rates: Rates of both cigarette and marijuana smoking initiation increased for children aged 12–17 years from 1965 through 1977. There was a statistically significant decrease in the slope of the calendar-period trend for lung cancer mortality in 1990 for both whites and blacks that was observed primarily in people 55 years of age and older. Conclusions and Implications: The birth-cohort pattern of lung cancer mortality after 1950 appears to reflect the early impact of teenage cigarette smoking on lung cancer risk in people under the age of 45 years, although a contribution from marijuana smoking cannot be ruled out. This result provides additional support for increasing smoking cessation and prevention programs for teenagers. The calendar-period decrease in lung cancer mortality after 1990 may reflect the long-term benefits of reductions in tobacco carcinogens in cigarettes and increases in smoking cessation beginning around 1960.
THE PHYSIOLOGY OF WORK
Authors: A. C. IVY
Journal: JAMA (1942)

The industries of our country have a tremendous task to perform. The successful accomplishment of this task depends primarily on the morale and physical fitness of our man power. Pearl Harbor and the fact that our sons are fighting constitute sufficient motivation for the maintenance of a high morale. It is the province of those charged with the maintenance of industrial health to increase and to conserve the physical fitness of the personnel in the office and in the factory. It is for this reason that I accepted the invitation to discuss "the physiology of work" before this group of physicians, whose responsibility in the emergency that confronts us is large. Even in ordinary times and apart from any sense of social responsibility, the industrial physician well knows that attention devoted to the health and well-being of executives and laborers is in the interest of efficient management. In physics and
Hematopoietic-Cell Transplantation for Chronic Granulomatous Disease
Authors: Adrian Thrasher, David Goldblatt
Journal: New England Journal of Medicine (2001)

The Sounding Board by Bedell et al. on the doctor's letter of condolence (April 12 issue) 1 was distressing to read.My wife of 40 years died at a prestigious teaching hospital.For nearly four years she had struggled with carcinoma of the fallopian tube.There were 26 hospital admissions for surgery, chemotherapy, or emergency rehydration.When standard approaches ultimately failed, she managed, largely through her own research, to become enrolled at another distinguished hospital in a high-risk experimental protocol: high-dose chemotherapy followed by transplantation of autologous bone marrow.But the regimen turned out to be lethal.She died after three days in the emergency cardiac unit.Neither the hospital management nor the attending physician or anyone from the house staff ever troubled to write or telephone to express sympathy or offer an account of what had gone so wrong those last disastrous days.The effect of that bizarre silence was to make me wonder whether some monumental mistake might have been made in preparing the dose that was to end her life.The next of kin are entitled to some expression of sympathy or concern, even when it is not deeply felt.Those close to the deceased can only be baffled, resentful, or suspicious when no condolences are expressed.
Effective risk stratification using exercise myocardial perfusion SPECT in women: Gender-related differences in prognostic nuclear testing
Authors: Rory Hachamovitch, Daniel S. Berman, Hosen Kiat, C.Noel Bairey Merz, Ishac Cohen, J.Arthur Cabico, John Friedman, Guido Germano, Kenneth F. Van Train, George A. Diamond
Journal: Journal of the American College of Cardiology (1996)
Detection of adenovirus and initiation of apoptosis in hepatocellular carcinoma cells after ad-p53 treatment
Authors: Ragai R. Mitry, Catherine E. Sarraf, Roman Havlík, Nagy A. Habib
Journal: Hepatology (2000)

Transcription of the p53 gene can regulate progression of apoptosis in a wide variety of tissues. Three categories of human hepatocyte culture have been used to show the initiation of apoptosis after treatment with p53-bearing adenovirus. Chang liver cells are derived from normal liver tissue and express native p53, whereas hepatocellular carcinoma (HCC)-derived cell lines were Hep3B (p53-deleted) and PLC/PRF/5 (p53-mutant). Cultures were infected with Ad-p53 (15 particles per cell; 36 hours), and after treatment, morphological changes in all cell categories were observed by electron microscopy. Infection was evident in the cytoplasm of all treated cell types: after entry across the plasma membrane viruses translocated and came to rest surrounding and adjacent to nuclei, cytoplasm proximal to nuclear membranes became dense with virus- and membrane-derived debris, but intact viruses did not enter nuclei. Apoptosis, recognized morphologically by characteristic chromatin and cytoplasmic condensation, occurred more frequently in HCC-derived cells, and the ultimate fate of apoptotic bodies was phagocytosis and degradation by neighboring cells.
Abstract 4612: Overexpression of cholesterol metabolism regulatory gene farnesyl diphosphate farnesyltransferase is associated with poor prognosis of non-small cell lung cancer patient and promotes metastasis through feedback regulation of SPP1-PI3K-AKT signaling pathway
Authors: Yi-Fang Yang, Hong-Yuan Tsia, Chien-Hsin Lee, Christina H Lim, Michael Hsiao
Journal: Cancer Research (2012)

Abstract Lung cancer is the leading cause of the human cancer-related death in the world and non-small cell lung cancer (NSCLC) accounts for up to 80 % of those patients. Cholesterol metabolism is especially active in cancer cells, whereas cholesterol synthesis inhibition has been show to reduce tumor cell growth. However, the involvement of farnesyl diphosphate farnesyltransferase (FDFT1) in lung cancer development and progression remains unclear. FDFT1 was involved in cholesterol biosynthesis. In this study, we investigated the clinical significance and biological effects of FDFT1 in NSCLC. Immunohistochemical studies performed on 141 primary NSCLC specimens revealed a high prevalence of FDFT overexpression (51%), which was significantly associated with lymph node metastasis (regional, P = 0.022), advanced tumor stage (P = 0.004), and poorer disease-free survival (P = 0.001, log-rank test; P = 0.001, Cox proportional hazard model). FDFT1 down-regulation by two shRNAs significantly reduced cell migration and invasion in highly invasive lung cancer cell lines in vitro, as well as lung metastases in vivo. Conversely, overexpression of FDFT1 in weakly invasive lung cancer cell lines in vitro and orthotopic metastasis assay in vivo shows enhanced cell motility and lung metastases. In addition, inhibition of FDFT1 decreased AKT activation and thereby suppressing the migration of human lung cancer cell in vitro. The results suggested that FDFT1 can positive feedback to regulate AKT. In weakly invasive lung cancer cell lines, FDFT1 overexpression was associated with the upregulation of secreted phosphoprotein 1(SPP1). The shRNA mediated knockdown of SPP1 was found to block FDFT1-enhanced invasion. Taken together, we have identified cholesterol metabolism regulatory gene FDFT1 as a cancer progression biomarker who overexpression leading to poor prognosis and result tumor metastasis feedback regulation of SPP1-PI3K-AKT signaling pathway. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 103rd Annual Meeting of the American Association for Cancer Research; 2012 Mar 31-Apr 4; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2012;72(8 Suppl):Abstract nr 4612. doi:1538-7445.AM2012-4612
Doctors are tending to be perceived as inherently bad
Authors: Francesco Carelli
Journal: BMJ (2004)

EDITOR—In his editor's choice Smith describes how doctors are mangled by “justice.”1 What's bad is bad, what's wrong is wrong, and wrongdoing has to be recognised and criminality punished. However, criminalisation of doctors seems to be the new way forward in society and increasingly in Europe.

Daily in Italy media reports mention the neologism “ …
Mental Health Services for Children and Adolescents
Authors: Paramjit T. Joshi
Journal: JAMA Psychiatry (2013)

11. Finger EC, Marsh AA, Blair KS, et al. Disrupted reinforcement signaling in the orbitofrontal cortex and caudate in youths with conduct disorder or oppositional defiant disorder and a high level of psychopathic traits. Am J Psychiatry. 2011;168(2):152-162. 12. Stringaris A, Goodman R. Longitudinal outcome of youth oppositionality: irritable, headstrong, and hurtful behaviors have distinctive predictions. J Am Acad Child Adolesc Psychiatry. 2009;48(4): 404-412.
ANURIA RELIEVED BY URETERAL CATHETERIZATION IN A CASE OF RENAL HYPOPLASIA
Authors: Julia C. Strawn
Journal: JAMA (1925)

A man, aged 45, was seen July 22, on account of severe left-sided renal colic, which had begun suddenly about eight hours before. About forty-eight hours before the onset, he had fallen into a lake, in a neighboring state, with his clothes on, and had become chilled. Several doses of morphin failed to relieve the left ureteral colic. During the first fourteen hours after admission, he passed 3½ ounces of urine, which did not show any albumin, and contained only an occasional white cell. During this period, nausea and vomiting were constant, and there was a frequent hiccup. Catheterization of the bladder about twenty hours after the onset yielded only 1 ounce of urine, of very dark color. A tentative diagnosis of almost complete anuria due to calculus obstruction of the ureter was made. Immediate cystoscopic examination was made, and relief by ureteral catheterization was advised. Cystoscopy revealed the presence
Integrin-Induced PIP5K1C Kinase Polarization Regulates Neutrophil Polarization, Directionality, and In Vivo Infiltration
Authors: Wenwen Xu, Ping Wang, Björn Petri, Yong Zhang, Wenwen Tang, Le Sun, Holger Kress, Thomas D. Manes, Yan Shi, Paul Kubes, Dianqing Wu
Journal: Immunity (2010)
Sequential delivery of TAT-HSP27 and VEGF using microsphere/hydrogel hybrid systems for therapeutic angiogenesis
Authors: Seung-Hwa Shin, Jangwook Lee, Kwang Suk Lim, Taiyoun Rhim, Sang Kyung Lee, Yong-Hee Kim, Kuen Yong Lee
Journal: Journal of Controlled Release (2012)
Angiographically Documented Late Reocclusion After Successful Coronary Angioplasty of an Infarct-Related Lesion Is a Powerful Predictor of Long-Term Mortality
Authors: Christophe Bauters, Maxence Delomez, Eric Van Belle, Eugène McFadden, Jean-Marc Lablanche, Michel E. Bertrand
Journal: Circulation (1999)

Late reocclusion of an infarct-related artery (IRA) that was patent in the early days after acute myocardial infarction (MI) is a frequent event; the reocclusion rate may be as high as 30%. Few studies have been designed to analyze the impact of late reocclusion of the IRA on late survival.We studied 528 patients who all had a patent IRA after a successful PTCA procedure 10+/-6 days after MI and who underwent systematic 6-month angiographic follow-up to assess late patency of the IRA. We compared long-term survival of patients with and without late reocclusion. Based on the results of 6-month follow-up angiography, 2 groups of patients were defined: (1) 90 patients (17%) with reocclusion (Thrombolysis In Myocardial Infarction [TIMI] flow 0 or 1) and (2) 438 patients (83%) without reocclusion. Long-term clinical follow-up was obtained for all 528 patients at a median of 5.7 years after follow-up angiography (6.4 years after PTCA). The overall actuarial 8-year total mortality rate was 13%. At the end of follow-up, there were 35 deaths (8%) among the 438 patients without reocclusion and 18 deaths (20%) among the 90 patients with reocclusion (P=0.002). The actuarial 8-year total mortality rate was 10% in patients without reocclusion and 28% in patients with reocclusion (P=0.0003). The actuarial cardiovascular mortality rate was 7% in patients without reocclusion and 25% in patients with reocclusion (P<0.0001). The impact of reocclusion on long-term mortality was greater in patients with anterior MI.Late IRA patency is strongly associated with long-term survival after MI. These observations should encourage prospective studies to evaluate the impact of strategies designed to prevent late reocclusion in postinfarction patients.
Changes of smoking habits and cough in men smoking cigarettes with 30% NSM tobacco substitute.
Authors: S Freedman, C M Fletcher
Journal: BMJ (1976)

The effects of smoking cigarettes with 30% of the tobacco replaced by NSM tobacco substitute, which lowered their tar and nicotine delivery, were studied by comparing them with the effects of conventional cigarettes in a controlled crossover trial lasting 20 months. Chest symptoms, cigarette consumption, and forced expiratory volume in one second (FEV1) were measured each month. Two-hundred men began the trial and 159 completed it. The test cigarettes were acceptable to all but one of the men. In a subsample of 35 men estimates of nicotine intake were obtained from monthly analyses of cigarette stubs. On changing from NSM to control cigarettes six of the 17 men, who were accustomed to low nicotine, kept their nicotine intake down by some change in smoking habit. Before the crossover and this change in smoking habit the men smoking NSM cigarettes had a small but significant reduction of cough. Cigarettes containing 30% NSM and delivering only 1 mg of nicotine are likely to be acceptable to smokers and may reduce coughing. Further trials are needed to confirm these findings and establish what long-term effects such cigarettes may have on smokers' health.
Evaluation of Pericardial Mesothelioma by Ga-67 and MRI
Authors: H SHIOTANI, H UENO, K MATSUNAGA, A MUROTANI, M YOSHIMURA, N TSUBOTA
Journal: Clinical Nuclear Medicine (1994)

The authors describe abnormal Ga-67 and magnetic resonance imaging in a 26-year-old man with a pericardial mesothelioma.
Clinical experience and psychometric properties of the Children's Dermatology Life Quality Index (CDLQI), 1995-2012
Authors: M.S. Salek, S. Jung, L.A. Brincat-Ruffini, L. MacFarlane, M.S. Lewis-Jones, M.K.A. Basra, A.Y. Finlay
Journal: British Journal of Dermatology (2013)

The Children's Dermatology Life Quality Index (CDLQI) is a widely used questionnaire to measure the quality of life of children aged from 4 to 16 years. The purpose of this review is to summarize all published data regarding the clinical experience of the CDLQI and its psychometric properties as a single reference source for potential users. A literature search was carried out to identify all articles describing the use of the CDLQI from 1995 to November 2012. One hundred and six articles were identified, with four excluded. The CDLQI has been used in 28 countries in 102 clinical studies and is available in 44 languages, including six cultural adaptations; a cartoon version is available in 10 languages. It has been used in 14 skin conditions and used in the assessment of 11 topical drugs, nine systemic drugs, 13 therapeutic interventions and two epidemiological and other studies. There is evidence of high internal consistency, test–retest reliability, responsiveness to change, and significant correlation with other subjective and objective measures. Rasch analysis has not been carried out and more information is needed concerning minimal clinically important difference; these are areas requiring further study.
Atrial Septal Defect in Infancy
Authors: RAJENDRA TANDON, JESSE E. EDWARDS
Journal: Circulation (1974)

The atrial septum was evaluated in necropsy specimens from subjects who died under the age of one year. Observations indicated that when an atrial septal defect (ASD) was present, there was commonly an associated condition. In the vast majority, the ASD was at the fossa ovalis and took the form of valvular incompetent foramen ovale. The findings strongly support the concept that an ASD at the fossa ovalis found in symptomatic infants is acquired secondary to the effects of an underlying anomaly. Overloading of the left or right atrium appears to be the mechanism resulting in the formation of an acquired ASD. In infants with various anomalies that cause overloading of the left atrium, such as left-to-right shunts from ventricular septal defect and left-sided inflow obstruction, the incidence of a defect at the fossa ovalis was 18% and 29%, respectively. A similar type of ASD was found in 31% of the cases with right-sided inflow or outflow obstruction.
Medical Care: Social and Organizational Aspects
Authors: Amasa B. Ford
Journal: JAMA (1967)

This book is as various as its subject. It consists of a series of 36 articles, originally published in the<i>New England Journal of Medicine</i>, on topics ranging from medical education, health services, and healthrelated organizations, to public and international health. The authors are experts of many kinds, predominantly physicians from the Boston and New York areas. The prevailing tone is that of expository status reports or position papers by experienced administrators. Most of the pieces are authoritative, and all are informative, although there is generally more opinion than fact. Notable exceptions are Weinerman's original and factual analysis of outpatient services, Anderson's survey of health service systems in various countries, and Peterson's review of the evaluation of the quality of medical care. Some articles stimulate interpretive thought, such as Ellis on regionalization of hospital services and Robertson on the role of private foundations in medicine. An occasional passage, such as
Cation Exchange Resin in the Treatment of Congestive Heart Failure
Authors: W. C. KLINGENSMITH, J. R. ELKINTON
Journal: Circulation (1952)

Thirty-four edematous cardiac patients who were being treated with cation exchange resin were studied for its long term effectiveness and for clinical and chemical complications. In 23 of 27 patients the resin was effective in terms of mobilizing edema fluid previously refractory to other forms of treatment, of partial or complete substitution for mercurial diuretics, and of permitting a slight increase in the salt content of the diet. Gastrointestinal intolerance was the chief clinical complication but prevented therapy in only five patients. Chemical complications of sodium depletion, potassium depletion or excess, and severe chloride acidosis were not seen.