tbuckley/cabot-search huggingface dataset:
Groups Urge Warning Label for Medical Devices Containing Toxic Chemical
Authors: Tracy Hampton
Journal: JAMA (2007)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
SHOULD NORMAL CUTOFF VALUES FOR E/E’ AND BNP DIFFER IN THE PRESENCE OF OBESITY?
Authors: Aaron Matthew From, Carolyn S.P. Lam, Sridevi R. Pitta, Prasanna V. Kumar, Kais A. Balbissi, Jeffrey D. Booker, Guy S. Reeder, Inder M. Singh, Paul Sorajja, Barry A. Borlaug
Journal: Journal of the American College of Cardiology (2010)
High death rates defended by paediatric cardiologist
Authors: C. Dyer
Journal: BMJ (1998)

The high death rate for children operated on by cardiac surgeon James Wisheart for atrioventricular septal defects was not due to the quality of the surgery, a leading paediatric cardiologist told the General Medical Council last week.

Elliot Shinebourne, a consult-ant at the Royal Brompton Hospital in London, said some of the children who underwent such surgery at Bristol Royal Infirmary should not, with hindsight, have been operated on. Some would have had a better chance of survival if surgery had been done at an earlier age before the progression of pulmonary vascular disease, and one child had a combination of defects that had never before been described, a combination of abnormalities that would have “taxed the most experienced surgeons in the world.”

Dr Shinebourne was giving evidence for Mr Wisheart, one of two surgeons accused of serious professional misconduct. Mr Wisheart and Janardan …
Large, Compressive Goiters Treated with Radioiodine
Authors: Dyde A.K.C. Huysmans
Journal: Annals of Internal Medicine (1994)

To evaluate the effectiveness of radioiodine therapy as an alternative for surgery in elderly patients with a large, compressive goiter using objective methods for measuring thyroid volume and tracheal compression.Prospective study.University hospital in the Netherlands.19 patients (mean age +/- SD, 66 +/- 14 years) with a large, compressive multinodular goiter who had a high operative risk or refused to have thyroid surgery.A single intravenous dose of 131I at 2.6 +/- 1.0 GBq (70 +/- 28 mCi) (3.7 MBq or 100 microCi/g of thyroid tissue), followed by daily administration of L-thyroxine in doses that did not suppress thyroid-stimulating hormone.Clinical evaluation and measurements of thyroid volume, maximal tracheal deviation, and the smallest cross-sectional area of the tracheal lumen with magnetic resonance imaging before and 1 year after 131I treatment.No exacerbation of compressive symptoms after 131I therapy was observed. Thyroid volume was 269 +/- 153 mL before treatment and 154 +/- 73 mL 1 year after treatment (P < 0.001). Thyroid volume was reduced 40% +/- 15% (range, 19% to 68%). Maximal tracheal deviation (1.9 +/- 0.8 cm before and 1.5 +/- 0.7 cm 1 year after therapy) had decreased by 20% +/- 20% (range, -4% to 73%; P < 0.001), and the smallest cross-sectional area of tracheal lumen (0.78 +/- 0.38 cm2 before and 1.04 +/- 0.48 cm2 1 year after therapy) had increased by 36% +/- 38% (range, -3% to 125%; P < 0.001). Clinical signs and symptoms improved in 8 of 12 patients with dyspnea and inspiratory stridor and in both patients with compression of the superior vena cava.Therapy with 131I is an effective alternative to surgery for elderly patients with a large, compressive multinodular goiter.
Dietary Fat and Its Relation to Heart Attacks and Strokes
Authors: Irvine H. Page, Edgar V. Allen, Francis L. Chamberlain, Ancel Keys, Jeremiah Stamler, Fredrick J. Stare
Journal: Circulation (1961)

CURRENT available knowledge is sufficient to warrant a general statement regarding the relation of diet to the possible prevention of atherosclerosis (Appendix I).A heart attack, also called coronary throm- bosis or myocardial infarction, or just plain "coronary, " is almost always caused by atheroselerosis (arteriosclerosis or hardening of the arteries).Stroke, or apoplexy, is often caused by the same condition.The problem of preventing or retarding these diseases is, then, one of preventing or retarding athero- sclerosis.How Does Atherosclerosis Develop?Atherosclerosis is a complex disease of the arteries.It is known that a number of factors influence or are related to its development.Among these factors are a high content in the blood of a type of fat called cholesterol.elevation of blood pressure above normal, presence of diabetes, obesity, and a habit of excessive cigarette smoking.Age, sex and heredity are also important. What Types of Research Relate Diet toAtherosclerosis?Many years ago a scientist fed cholesterol and other types of fat to rabbits.The blood cholesterol content increased and the rabbits developed atherosclerosis; that is, cholesterol and other fatty substances were deposited in the walls of the arteries.Many other animal species have been found to behave similarly.These animal experiments indicate that diet may be an important cause of atherosclerosis.Global studies have shown that dietary habits of human populations differ.Evidence gathered from many couiitries suggests a re- lationship between the amount and type of *The Central Commiinittee for Medical and Community Program is the senior medical body of the Ameri- can Heart Association and is chaired by A. Carnton
Late FDG PET Normalization After Radioimmunotherapy in a Patient With Non-Hodgkin Lymphoma
Authors: Anna Margherita Maffione, Paolo Castellucci, Vittorio Stefoni, Cristina Nanni, Monica Tani, Domenico Rubello, Valentina Ambrosini, Pierluigi Zinzani, Roberto Franchi, Stefano Fanti
Journal: Clinical Nuclear Medicine (2009)

Fluoro-deoxy-glucose positron emission tomography (FDG PET) has largely been used for response assessment after treatment of lymphoma, resulting in a very sensitive and specific imaging technique for the detection of residual disease. For this reason FDG PET has recently been proposed to be integrated in the International Workshop Criteria. In this report, a patient with non-Hodgkin lymphoma was treated with radioimmunotherapy for disease relapse, demonstrated by PET. Post-treatment evaluation was performed 9 weeks after treatment, and PET showed almost complete disappearance of tracer uptake, but with faint persistence of uptake at 1 iliac node and thus was a suspect for residual disease. However, a wait-and-see approach was decided and the patient was rescanned with PET 18 weeks after treatment, and the results were finally negative. This case indicates that after completion of radioimmunotherapy it may be recommended to wait several weeks before performing a PET scan and, in case of minimal findings, to consider a short-term re-evaluation.
Clinical end points for drug treatment trials in BCR-ABL1-negative classic myeloproliferative neoplasms: consensus statements from European LeukemiaNET (ELN) and Internation Working Group-Myeloproliferative Neoplasms Research and Treatment (IWG-MRT)
Authors: G Barosi, A Tefferi, C Besses, G Birgegard, F Cervantes, G Finazzi, H Gisslinger, M Griesshammer, C Harrison, R Hehlmann, S Hermouet, J-J Kiladjian, N Kröger, R Mesa, M F Mc Mullin, A Pardanani, F Passamonti, J Samuelsson, A M Vannucchi, A Reiter, R T Silver, S Verstovsek, G Tognoni, T Barbui
Journal: Leukemia (2014)
In vitro myotrophic effect of serum kappa chain immunoglobulins from a patient with kappa light chain myeloma and muscular hypertrophy.
Authors: C Delaporte, B Varet, M Fardeau, D Nochy, A Ract
Journal: Journal of Clinical Investigation (1986)

Muscle hypertrophy due to enlarged muscle fibers was accompanied by kappa light chain myeloma in a 62-yr-old man. Immunofluorescence showed kappa light chain deposits around muscle fibers. We hypothesized that a circulating growth factor may be involved in the pathogeny of this muscular hypertrophy. Patient serum cultured with muscle cells showed that (a) the patient's serum exhibited a trophic effect on human muscle cells in culture, (b) this trophic effect increased the differentiation and did not influence the proliferation of human muscle cells, and (c) the fraction of the patient's serum immunoadsorbed on antihuman kappa chain antibodies exhibited the same in vitro effect on the muscle cells, whereas the fraction immunoadsorbed on antihuman lambda chain antibodies did not. These results support the hypothesis that the patient's kappa light chains have a specific enhancing effect on human muscle cell differentiation, perhaps leading to an acquired muscular hypertrophy.
Deprivation and general practitioner workload.
Authors: R. Balarajan, P. Yuen, D. Machin
Journal: BMJ (1992)

OBJECTIVES--To examine general practitioner consultations by demographic and socioeconomic variables and to derive a method of measuring the impact of relative deprivation on general practitioner workload. DESIGN--The study was based on general practitioner consultations reported in the general household surveys of 1983-7, covering a sample of 129,987 individuals in Great Britain. Odds ratios for general practitioner consultations were obtained for selected variables among children (0-15 years), men (16-64), women (16-64), and elderly people (greater than or equal to 65). These were then used to derive deprivation indices specific to electoral wards for use in general practice. SETTING--Great Britain, with particular findings illustrated by English electoral wards and the conurbations of London, Manchester, Merseyside, and the West Midlands. RESULTS--Council tenure increased the likelihood of consultation significantly in all four groups. Odds ratios were raised in children, men, and women with no access to a car. Birth in the New Commonwealth or Pakistan yielded high odds ratios in men, women, and elderly people but not in children. Marginally increased consultation rates were evident in the manual socioeconomic groups in women, elderly people, and children with a single parent mother. The deprivation indices for general practice derived using these odds ratios varied substantially among English electoral wards with, for example, anticipated general practitioner consultations in the electoral ward of Hulme, Manchester, being 24% higher than the average ward in England as a result of local attributes, and consultations in the Cheam South ward of Sutton, London, 11% lower than average. CONCLUSION--This deprivation index for general practice overcomes several shortcomings expressed about the underprivileged area score, which has been adopted in the 1990 contract as a basis for allocating deprivation supplements to general practitioners. The proposed index can be applied nationwide.
Antibodies to native DNA in discoid lupus erythematosus
Authors: P. DAVIS, BRENDA ATKINS, G.R.V. HUGHES
Journal: British Journal of Dermatology (1974)

DNA antibodies, known to be highly specific for systemic lupus erythematosus, have been measured in twenty‐seven cases of discoid lupus erythematosus, without evidence of systemic involvement. In seven (27°), DNA antibodies have been found in the range normally associated with active SLE. It is suggested that these results support the concept that discoid LE and SLE are closely related diseases, and that the finding of DNA antibodies in patients with discoid LE may be of value in management and prognosis.
Role of zinc in formulation of PLGA/PLA nanoparticles encapsulating betamethasone phosphate and its release profile
Authors: Tsutomu Ishihara, Nobuo Izumo, Megumu Higaki, Emi Shimada, Tomomi Hagi, Lisa Mine, Yasuaki Ogawa, Yutaka Mizushima
Journal: Journal of Controlled Release (2005)
Virtual Colonoscopy: Time for Some Tough Questions for Radiologists and Gastroenterologists
Authors: D. K. Rex
Journal: Endoscopy (2000)

The study by Kay and colleagues in this issue of Endoscopy [1], when published in abstract form [2] [3] was the first blinded prospective study (to my knowledge) to demonstrate a sensitivity of computed tomographic (CT) colonography of ≥ 90 % for polyps ≥ 1 cm in size. Prior to publication of this study in manuscript form, others have reported similar sensitivity for CT [4] [5] [6] or magnetic resonance (MR) [7] colonography, and perhaps extended this level of sensitivity to 6 - 9 mm polyps [8]. CT and MR colonography are continuing to evolve rapidly and improve. Image acquisition will be faster and better with multislice scanners, which are being installed in the United States at a remarkable pace. Image rendering and display have improved, and will improve, at an even more rapid pace. lt seems all but certain that CT and MR colonography will achieve sufficient sensitivity and specificity to become important options in colorectal neoplasia screening, diagnosis, and surveillance.
HRT modulates brachial artery diameter and flow-mediated dilation: the NHLBI-sponsored Women's Ischemia Syndrome Evaluation (WISE) study
Authors: B.Delia Johnson, Richard Holubkov, C.Noel Bairey Merz, Carl J. Pepine, William J. Rogers, Nathaniel Reichek, Barry L. Sharaf, Sheryl F. Kelsey, George Sopko, Steven E. Reis
Journal: Journal of the American College of Cardiology (2002)
A Post-mortem Examination in a Case of Appendiceal Abscess.
Authors: J. F. Jenkins
Journal: JAMA (1895)

Tecumseh, Mich., July 13, 1895. <h3>To the Editor:</h3> —Mrs. B., age about 54 years, was confined to her bed on the first of July of the present year. The family sent for a homeopath, who appears to have had not the slightest idea of the nature of her illness, but apparently satisfied the gullibility of the friends until the death of the patient, which occurred ten days from the commencement of the attack. After death, the friends became anxious to know the cause, and whether, or not, the patient died from neuralgia of the heart, which was the cause assigned by this ignorant homeopath. At the solicitation of the family, three physicians (including the writer), and two homeopaths attended the post-mortem examination. Upon opening the abdominal cavity, there was found a ruptured appendiceal abscess which occurred a few hours before death; doubtless the rupture was produced by the attendant pressing
Sex-Based Analysis of Outcome in Patients With Acute Myocardial Infarction Treated Predominantly With Percutaneous Coronary Intervention
Authors: Julinda Mehilli
Journal: JAMA (2002)

A higher mortality risk for women with acute myocardial infarction (AMI) is a common finding in studies that compare the postinfarction outcome of women vs men. It is not clear, however, whether sex is an independent predictor of death among patients systematically treated with aggressive reperfusion and medical strategies.To assess the impact of patient's sex on outcome in a consecutive series of patients with AMI treated with a reperfusion strategy largely based on percutaneous coronary interventions.Inception cohort of 1937 patients (502 women and 1435 men) who were admitted with a diagnosis of AMI to a tertiary referral institution between January 1995 and December 2000.Mortality at 1 year after AMI.Compared with men, women were older (70 vs 61 years; P<.001) and had known diabetes or hypertension more often. Both men and women received essentially identical therapy with the majority of patients (86%) receiving reperfusion therapy via percutaneous coronary interventions. There were no significant differences in 1-year Kaplan-Meier death rates with 13.8% (68 cases) among women and 12.9% (184 cases) among men (unadjusted hazard ratio, 1.06; 95% confidence interval, 0.80-1.39; P =.70). After age adjustment, women had a lower risk of death (hazard ratio, 0.65; 95% confidence interval, 0.49-0.87; P =.004).Despite their more advanced age and greater prevalence of diabetes or hypertension, women with AMI who were treated with a reperfusion strategy largely based on percutaneous coronary interventions show a similar outcome as men.
Inadvertent Intra-arterial Injection
Authors: William H. Hardesty
Journal: JAMA (1970)

<h3>To the Editor. —</h3> Doctors Morgan, Waugh, and Boback's recent article (<b>212</b>:476-478, 1970) prompted me to write this letter alerting physicians to the problem of inadvertent intraarterial injection which is not restricted to self-administration. Even in competent hands limb loss has resulted from medication intended to be given intravenously being given intra-arterially.<sup>1</sup>Hydroxyzine hydrochloride (Vistaril) has been known to produce necrosis of the upper extremities following intra-arterial injection.<sup>2</sup> Presumably because of the following case and others like it, hydroxyzine has been withdrawn from the market as an intravenous medication. <h3>Report of a Case.—</h3> A 23-year-old, five months pregnant woman was admitted to the Mercer Hospital with a history of having received an injection in her left antecubital space three days before, administered by her physician. The medication injected was hydroxyzine and, for all intents and purposes, was administered intravenously. However, during the injection, the patient complained of
A novel ALL-L3 cell line, BALM-16, lacking expression of immunoglobulin chains derived from a patient with hypercalcemia
Authors: Y Matsuo, RAF MacLeod, K Kojima, K Kuwahara, A Sakata, HG Drexler, C Nishizaki, S Fukuda, Y Inoue, T Sezaki, N Sakaguchi, K Orita
Journal: Leukemia (1997)
Civil Defense Agency
Authors: Thomas F. Maher
Journal: New England Journal of Medicine (1955)

BASIC MEDICAL PROBLEMS ASSOCIATED WITH ATOMIC EXPLOSIONSThe clinical problems associated with the use of radium and x-rays are now well known, as are the conditions that may arise from the medical use of radioactive isotopes. With the more widespread use of atomic power and fissionable material by industry in the future, more problems concerning clinical medicine and industrial hygiene will arise. Atomic explosions of the future may be of civilian origin, such as an industrial accident, or may follow an enemy attack.The commonest clinical condition caused by atomic explosion is blast injury. There are two main types: the . . .
Interactions of aniline with soil and groundwater at an industrial spill site.
Authors: D S Kosson, S V Byrne
Journal: Environmental Health Perspectives (1995)

The interactions of aniline with soil at an industrial spill site were investigated. Sorption of aniline to the soil was observed to occur through a two-step mechanism. The first step was an ion exchange process with the protonated amine serving as an organic cation. This step was influenced by solution pH and ionic composition. The second step was covalent bonding most likely with quinone moieties and oxidation with polymerization of aniline. The extent of covalent bonding was influenced by the presence of oxygen and redox potential. The majority of aniline that was bound to the soil did not readily desorb under a variety of abiotic conditions. However, aniline was released to a significant extent in the presence of denitrifying and methanogenic microbial activity. Aniline in aqueous solution was readily biodegradable under aerobic and denitrifying conditions. Soil-bound aniline was observed not to be biodegradable. This paper provides an overview of results.
Effects of Phenoxybenzamine in Shock due to Myocardial Infarction
Authors: J. F. Riordan, G. Walters
Journal: BMJ (1969)

Treatment of cardiogenic shock with vasodilator drugs has been advocated on the basis of experimental work showing that a fall in peripheral resistance allows the cardiac output to increase without any increase in cardiac work.Seven patients suffering from shock secondary to myocardial infarction were treated with phenoxybenzamine. In two cases there was dramatic improvement in the signs and symptoms of shock, but in six of the seven cases there were severe adverse effects on respiration, including the development of wheezing and rales and rhonchi.
Prediction of sensitization to flour allergens
Authors: W. Popp, C. Wagner, D. Kiss, H. Zwick, K. Sertl
Journal: Allergy (1994)

The purpose of the present study was to investigate the factors that may contribute to the sensitization to flour in baker's apprentices, and to predict this type of sensitization with a stepwise logistic regression model. Of the total of 258 baker's apprentices, 54 (20.9%) exhibited specific IgE development against flour allergens (wheat, rye, and/or barley). Allergologic variables, such as the total IgE level and IgE specific to grass pollen, tree pollen, weed pollen, molds, and animal dander, were found to correlate strongly with the sensitization to flour. However, the correlation between the presence of other manifest allergies and the sensitization to flour was weak. The presence of shadowing of the paranasal sinuses on the radiograph (mucosal thickening, opacity, air/fluid levels, and/or polypous shadowing) correlated with flour sensitization as well as with the leukocyte and lymphocyte counts in peripheral blood. Of the lung function data, only total lung capacity (in percentage of the predicted values) weakly correlated with the sensitization to flour. We were able to predict flour sensitization with a sensitivity of 63%, a specificity of 90%, and an efficiency of 84% by using the parameters that allow for the presence or absence of IgE specific to grass pollen and tree pollen, the presence or absence of radiographic shadowing, and total lung capacity in percentage of the predicted values.
The Next Ten Years in Medicine
Authors: Galdwell B. Esselstyn
Journal: New England Journal of Medicine (1962)

THOSE who spent three hours to see "Around the World in Eighty Days" will sympathize with anyone assigned twenty minutes to cover the next ten years in medicine. This paper is written with the complete realization of the sketchiness any such schedule demands, and is simply an attempt to include not all, but some, interesting issues.It has often been said that the best way to see ahead is to look behind, and if we do this we find in the field of medicine certain forces at work which will inevitably have continuing influence on the shape of things to . . .
Relationship between polymorphisms 804C/A and 252A/G of lymphotoxin-α gene and −308G/A of tumor necrosis factor α gene and diabetic retinopathy in Japanese patients with type 2 diabetes mellitus
Authors: Keiji Yoshioka, Toshihide Yoshida, Yasuto Takakura, Tsunekazu Umekawa, Akinori Kogure, Hitoshi Toda, Toshikazu Yoshikawa
Journal: Metabolism (2006)
Endoscopic diagnosis of secondary aortoesophageal fistula
Authors: T. Akaraviputh, T. Sriprayoon, V. Prachayakul, P. Sakiyalak
Journal: Endoscopy (2008)

Secondary aortoesophageal fistula (AEF) is a catastrophic complication of endovascular graft placement [1]. The typical symptom of secondary AEF is massive gastrointestinal bleeding with a history of thoracic aortic aneurysm repair [2]. Endoscopy is the most sensitive and specific diagnostic study [3]. Endoscopy should be carefully performed, as it excludes other, more common causes of upper gastrointestinal bleeding, but should be terminated if a fistula is identified. We present an endoscopic finding of secondary AEF.