Tropical Sprue—An Iceberg Disease?
Authors: FREDERICK A. KLIPSTEIN
Journal: Annals of Internal Medicine (1967)

Editorial Notes1 March 1967Tropical Sprue—An Iceberg Disease?FREDERICK A. KLIPSTEIN, M.D.FREDERICK A. KLIPSTEIN, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-66-3-622 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe presence of overt tropical sprue in endemic, and occasionally epidemic, form has been recognized in certain islands of the Caribbean, the Indian subcontinent, and Southeast Asia for more than 2 centuries. Patients with the overt form of this disease usually present with gastrointestinal symptoms and weight loss and are found to have villose atrophy and malabsorption. Impaired intestinal absorption results in the development of multiple deficiencies that become clinically manifest with progression of the disease.The increasingly widespread use of peroral jejunal biopsy for the evaluation of intestinal disorders during the past several years has made evident that the...References1. SPRINZSRIBHIBHADHGANGAROSABENYAJATIKUNDELHALSTEAD HREJCDS: Biopsy of small bowel of Thai people. With special reference to recovery from Asiatic cholera and to an intestinal malabsorption syndrome. Amer. J. Clin. Path. 38: 43, 1962. CrossrefMedlineGoogle Scholar2. BAKERIGNATIUSMATHANWAISHCHACKO SJMVISKCC: Intestinal Biopsy, Ciba Foundation Study Group No. 14. Little, Brown and Co., Boston, 1962, p. 84. Google Scholar3. KLIPSTEINSAMLOFFSCHENK FAIMEA: Tropical sprue in Haiti. Ann. Intern. Med. 64: 575, 1966. LinkGoogle Scholar4. BANWELLHUTTTUNNICLIFFE JGMSR: Observations on jejunal biopsy in Ugandian Africans. E. Afr. Med. J. 41: 46, 1964. MedlineGoogle Scholar5. ACOSTA-MATIENZOCOLL COMALEZCINTRON-RIVERA JGAA: Serum folate levels in relatives of patients with tropical sprue. Clin. Res. 14: 290, 1966. Google Scholar6. KLIPSTEINSCHENKSAMLOFF FAEAIM: Folate repletion associated with oral tetracycline therapy in tropical sprue. Gastroenterology 51: 317, 1966. CrossrefMedlineGoogle Scholar7. O'BRIENENGLAND WNW: Military tropical sprue from South-east Asia. Brit. Med. J. 2: 1157, 1966. CrossrefMedlineGoogle Scholar8. KLIPSTEINSCHENKCUNNINGHAMSMARTHSAMLOFF FAEAJKGIM: Treatment of overt and asymptomatic tropical sprue in Haiti. In preparation. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Department of Medicine Columbia University College of Physicians and Surgeons New York, N. Y. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByEnteropatia ambientalTropical enteropathy: a T-cell-mediated crypt hyperplastic enteropathyTropical Sprue and Subclinical Enteropathy: A Vision for the NinetiesGluten sensitivity and latency: Can patterns of intestinal antibody secretion define the great ‘silent majority?’Small bowel morphology in British Indian and Afro-Caribbean subjects: evidence of tropical enteropathy.Idiopathic Small Intestinal Disease in the TropicsSPRUE AND SUBCLINICAL MALABSORPTION IN THE TROPICSNON-SPECIFIC ILEOJEJUNITIS IN AREQUIPA, PERUContamination of the Small Intestine by Enterotoxigenic Coliform Bacteria among the Rural Population of HaitiGastrointestinal Alterations in Protein-Calorie MalnutritionTropical EnteropathyCŒLIAC DISEASE IN CHILDREN OF ASIAN IMMIGRANTSSmall intestinal villous pattern and mucosal dynamics in healthy JamaicansRecovery of Small-Intestinal Structure and Function After Residence in the Tropics I. Studies in Peace Corps VolunteersJOHN LINDENBAUM, M.D., CHARLES D. GERSON, M.D., THOMAS H. KENT, M.D.Intestinal Morphology of Rural HaitiansNeomycin-Induced Malabsorption in a Tropical PopulationSulfonamides and Tropical SprueTreatment of overt and subclinical malabsorption in Haiti.Tropical Sprue—Specific Disease or Extreme of a Spectrum?ARTHUR B. FRENCH, M.D., F.A.C.P.Potential Medical Problems in Personnel Returning from VietnamDAVID N. GILBERT, WILLIAM L. MOORE JR., CHARLES L. HEDBERG, JAY P. SANFORD, M.D., F.A.C.P.Tropical SprueCytology of Intestinal Epithelial Cells 1 March 1967Volume 66, Issue 3Page: 622-623KeywordsAtrophyBiopsyTropical diseasesWeight loss Issue Published: 1 March 1967 PDF DownloadLoading ...