Optimal Timing of Initial Breast Cancer Surgery
Authors: Avrum Z. Bluming, William J. M. Hrushesky
Journal: Annals of Internal Medicine (1992)

Letters1 February 1992Optimal Timing of Initial Breast Cancer SurgeryAvrum Z. Bluming, MD, William J. M. Hrushesky, MDAvrum Z. Bluming, MDSearch for more papers by this author, William J. M. Hrushesky, MDSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-116-3-268_2 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the Editors: In his editorial (1), Dr. McGuire concludes that he cannot be sure of any apparent benefit from timing of initial breast cancer surgery in relation to the patient's menstrual cycle because all published studies dealing with the question have been retrospective. He suggests that a properly designed prospective study be done to resolve this question. We suggested the same in our original 1989 article (2), and subsequently.Dr. McGuire's witty argument, about the inevitability of statistically significant results due only to chance, is misleading. He neglects to mention that the hypothesis that surgical timing within the fertility...References1. McGuire W. The optimal timing of mastectomy: low tide or high tide? Ann Intern Med. 1991;115:401-3. LinkGoogle Scholar2. Hrushesky W, Bluming A, Gruber S, and Sothern R. Menstrual influence on surgical cure of breast cancer. Lancet. 1989;2:949-52. CrossrefMedlineGoogle Scholar3. Hrushesky W, Bluming A, and Gruber S. Menstrual status and breast cancer surgery—reply. Breast Cancer Res Treat. 1990;16:121. CrossrefGoogle Scholar4. Bluming A and Hrushesky W. The effect of surgical timing within the fertility cycle on breast cancer outcome. Ann NY Acad Sci. 1991;618:277-91. CrossrefMedlineGoogle Scholar5. Ratajczak H, Sothern R, and Hrushesky W. Estrous stage influences surgical cure of a mouse breast cancer. J Exp Med. 1988;168:88-96. CrossrefGoogle Scholar1. McGuire W. The optimal timing of mastectomy: low tide or high tide? Ann Intern Med. 1991;115:401-3. LinkGoogle Scholar2. Hrushesky W, Bluming A, Gruber S, and Sothern R. Menstrual influence on surgical cure of breast cancer. Lancet. 1989;2:949-52. CrossrefMedlineGoogle Scholar3. Senie T, Rosen P, Rhodes P, and Lesser M. Timing of breast cancer excision during the menstrual cycle influences duration of diseasefree survival. Ann Intern Med. 1991;115:337-42. LinkGoogle Scholar4. Badwe R, Gregory W, Chaudary M, Richards M, Bentley A, and Rubens R. Timing of surgery during menstrual cycle and survival of premenopausal women with operable breast cancer. Lancet. 1991;337:1261-4. CrossrefMedlineGoogle Scholar5. Rageth J, Wyss P, Unger C, and Hochuli E. Timing of breast cancer surgery within the menstrual cycle: influence of lymph-node involvement, receptor status, postoperative metastatic spread and local recurrence. Ann Oncol. 1991;2:269-72. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: Avrum Z. Bluming, MD; William J. M. Hrushesky, MDAffiliations: University of Southern California Encino, CA 91436 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byTiming of breast cancer surgery, menstrual phase, and prognosis: Systematic review and meta-analysisThe timing of breast cancer surgery within the menstrual cycleOestradiol stimulates growth of oestrogen receptor-negative MDA-MB-231 breast cancer cells in immunodeficient mice by reducing cell lossTiming of breast cancer surgery — some arguments that there is no effectTiming of breast cancer surgery during the menstrual cycleMenstrual effects on surgical treatment for breast cancer 1 February 1992Volume 116, Issue 3Page: 268-269KeywordsBreast cancerMenstrual cycleProspective studiesRetrospective studiesSurgery ePublished: 1 December 2008 Issue Published: 1 February 1992 PDF downloadLoading ...