tbuckley/cabot-search huggingface dataset:
Abstract 2565: Conformation overrides base sequence - insights from a novel class TLR-9 agonists
Authors: Kerstin Kapp, Christiane Kleuss, Matthias Schroff, Burghardt Wittig
Journal: Cancer Research (2014)

Abstract Introduction DNA-based TLR-9 agonists are potent activators of immune cell populations and the immune system. Preclinical and ongoing clinical studies support the use of TLR-9 agonists as immunomodulators and/or adjuvants, and proof their anti-tumor effect by enhancing both the humoral and cellular responses. From the 4 classes of known activators with distinct immunomodulation profiles all members except one comprise of linear DNA molecules. The exception is dSLIM®, the active ingredient of MGN1703 in several clinical trials. dSLIM® establishes a new class of TLR-9 agonists, represented by covalently closed dumbbell-like DNA molecules consisting entirely of natural DNA with two single-stranded CG-containing loops separated by a double-stranded stem. Results By cytokine secretion and cellular activation of relevant cells in human PBMC we show that CG-motifs - such as in ODN2006, a class B TLR9 agonist - if incorporated in dSLIM® conformation reveal an improved immunomodulatory potential compared to their corresponding linear CpG oligonucleotides. Increased cytokine secretion encompasses the central anti-cancer cytokine IFN-alpha, the potent angiostatic cytokine IP-10, or IFN-gamma the key activator of NK-, NKT-, and cytotoxic T-cell responses. After 24-48h exposure to dSLIM® TLR-9 agonists, also activation surface markers of relevant cell subpopulations of PBMC are up-regulated including CD80 of pDCs, CD86 of B-cells, CD86 and CD169 of monocytes, CD69 of NK, NKT as well as T cells. Consequently, dSLIM® triggers an explicit specific cytotoxicity against Jurkat target cells while ODN2006 is without significant effect in this readout. All these effects are considered important and relevant cancer-fighting features of dSLIM®. Conclusions Differences in immunomodulation profiles between classes of TLR-9 agonists appear to be more closely related to their conformation than their individual nucleotide sequences. We show individual loop sequences in dSLIM® that differentiate the immunomodulation profile of molecules only to a moderate extent. Inherent to the dumbbell-like structure of dSLIM® TLR-9 agonists is their potential to dimerize loop-binding TLR-9 molecules in the membrane of immune-competent cells. Thereby, dSLIM® TLR-9 agonists most probably not only bind and activate but also cluster TLR-9 molecules thereby changing the TLR-9 triggered immune response in a qualitative way. Stabilizing chemical modifications in linear CpG ODN also impact the immunomodulatory profile of TLR-9 agonists and are discussed. Citation Format: Kerstin Kapp, Christiane Kleuss, Matthias Schroff, Burghardt Wittig. Conformation overrides base sequence - insights from a novel class TLR-9 agonists. [abstract]. In: Proceedings of the 105th Annual Meeting of the American Association for Cancer Research; 2014 Apr 5-9; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2014;74(19 Suppl):Abstract nr 2565. doi:10.1158/1538-7445.AM2014-2565
The Comparative Anatomy and Histology of the Cerebellum from Myxinoids through Birds.
Authors: Olof Larsell, Jan Jansen
Journal: Annals of Internal Medicine (1967)

Comparative Anatomy and Histology of the Cerebellum From Myxinoids Through Birds. By Olaf Larsell, PhD. Edited by Jan Jansen, MD. Pp 291, Price, $14. University of Minnesota Press, Minneapolis 14. Mav 10. 1967. This book was produced posthumously with Jan Jansen of Oslo as editor. This is the first volume of a two-volume reference work, the continuation to be devoted to the cerebellum of mammals. It is a magnificent study to which Dr. Larsell devoted the last ten years of his life and gives every promise of becoming a classic of its kind. In the tradition of our other great works in comparative neurology (Herrick, Kappers, Huber and Crosby), its emphasis is upon structural relations developed in the phylogenetic context. Following a brief introduction which covers the history of the cerebellum and the general principles involved in establishing homologies in the cerebellar lobules between different species, genera orders, and classes, the main text divides into 16 sections covering protovertebrates and vertebrates through the birds. The editorial plan for subdivision of the sections is a wise one, evolving in a systematic fashion as the cerebellum evolves and permitting ready cross-reference between the topic areas of the different sections. The book is well but not excessively illustrated contrasting it with those anatomical studies of the cerebellum which depend extensively upon illustrations and their legends inter¬ spersed by complex wiring diagrams to con¬ vey information. The text is lucid; the refer¬ ences, comprehensive. The whole provides a book of excellent readability. The work is published during a renais¬ sance of interest in the cerebellum. Repre¬ senting the culmination of a scientific life spent in the pursuit of the secrets of that or¬ gan, it serves as a delicate reminder that the cerebellum will continue to yield its major secrets stubbornly in spite of its presumed simplicity of substrate and a prevailing eleetrophysiological optimism that ultima thule is in sight if not actually upon us. William James once wrote that the best way to spend a life is for something that out¬ lasts. It is a tribute to Larsell that he built his life upon that approach to neurological science. J. L. O'leary, MD
IS7. lung cancer
Authors: J. C. H. Yang, Y.-L. Wu, J. S.-K. Au, S. Yuankai, S. Thongprasert, S. Srinivasan, C.-M. Tsai, M. T. Khoa, K. Heeroma, Y. Itoh, G. Cornelio, P.-C. Yang, J. O'Connell, A. Bottomley, S. S Ramalingam, M. J. Boyer, K. Park, F. Blackhall, R. Mundayat, S.-Y. Lee, A. Campbell, J.-M. Sun, S.-W. Kim, M.-J. Ahn, J. S. Ahn, D. H. Lee, Y. C. Ahn, H. Pyo, E. K. Choi, S. Y. Song, S.-H. Lee, C. Suh, J. S. Lee, T. Hida, K. Kubota, S. Ishikura, T. Shibata, M. Nishio, M. Kawahara, A. Yokoyama, F. Imamura, K. Takeda, S. Negoro, H. Okamoto, N. Yamamoto, T. Shinkai, N. Saijo, T. Tamura, H. Kaneda, Y. Kotani, M. Satouchi, M. Ando, Y. Ichinose, Y. Ohe, S. Kudoh, K. Minato, A. Inoue, M. Maemondo, S. Sugawara, T. Harada, Y. Minegishi, K. Usui, N. Morikawa, Y. Mori, O. Ishimoto, N. Matsubara, T. Sakakibara, K. Watanabe, A. Gemma, T. Nukiwa, T. Shukuya, S. Atagi, T. Sawa, K. Mori, T. Kumagai, R. Sekiguchi, S. Enatsu, K. Nakagawa, Y. Urata, I. Okamoto, Y. Hattori, K. Okuno, T. Shimada, M. Takeda, T. Kurata, M Miyazaki, M. Terashima, K. Tanaka, S Morita, H. Murakami, T. Seto, K. Kiura, D.-W. Kim, Y. Shi, T. M. De Pas, G. J. Riely, L. Crinò, T. L. Evans, X. Liu, J.-Y. Han, R. Salgia, S. Lanzalone, A. Polli, S. Iyer, A. T. Shaw, G. V. Scagliotti, S.-H. I. Ou, S. N. Gettinger, B. Besse, M. Thomas, K. Wilner, C. H. Bartlett, D. R. Gandara, Y.-J. Bang, S. Ou, D. R. Camidge, J. W. Clark, L. Tye, P. Stephenson, M. Varella-Garcia, A. J. Iafrate, G. Scagliotti, D. Spigel, J. H. Kim, T.-C. Hsia, R. K. Li, B. Tiangco, S. Yau, W.-T. Lim, B. Yao, Y.-j. Hei, M. G. Kris, T. Mok, R. G. Martins, Z. Goldberg, H. Zhang, I. Taylor, S. P. Letrent, P. A. Jänne, E. Ichihara, A. Hisamoto, S. Harita, Y. Segawa, H. Kamei, T. Shibayama, K. Gemba, K. Hotta, K. Matsuo, K. Aoe, N. Takigawa, M. Tabata, M. Tanimoto, S. Niho, H. Sakai, H. Isobe, H. Kunitoh, Y. Takiguchi, K. Kobayashi, Y. Nakamura, N. Katakami, M. Takeuchi
Journal: Annals of Oncology (2012)
Comparison between dual-energy computed tomography and standard lung perfusion scintigraphy in preoperative evaluation of lung cancer patients
Authors: Johannes Mueller, Helene Vogelsinger, Florian Augustin, Wolfgang Recheis, Tobias De Zordo, Gudrun Feuchtner, Christian Kaehler
Journal: European Respiratory Journal (2013)

Background    :   In the pre-operative assessment of lung cancer patients functional evaluation of operability is a crucial step. It includes, apart from spirometry, measurement of diffusion capacity and exercise testing, split function studies by means of lung perfusion scintigraphy. Using this approach it is possible to predict postoperative lung function and therefore assess resection limit and operability. As computed tomography (CT) is essential for pre-operative evaluation in every patient, a recently advanced CT-protocol, the so called dual-energy computed tomography (DECT), by which lung tissue perfusion gets visible, might be a new and better alternative to radioactive scintigraphy.    Objectives    :   To compare calculated percentage values for perfused lung tissue, as measured on the one hand by lung perfusion scintigraphy and on the other hand gathered by DECT.    Methods    :   Seven patients were included in this pilot project. All patients had to undergo lung perfusion scintigraphy, as well as dual-energy computed tomography a few days before surgery. Lung function testing and assessment of diffusion capacity was performed in all patients preoperatively.    Results    :   Patients (mean age 61±8 yrs) were investigated by scintigraphy and DECT. Split studies revealed no significant difference in calculated percentages for lung perfusion between both methods ( p >0.05). Values for the FEV1 ppo did not differ between scintigraphy or DECT results which served as basis for calculation.  Conclusion    :   There is no significant divergence between the use of dual-energy CT and lung perfusion scintigraphy for pre-operative evaluation of lung cancer patients.
My famous friends.
Authors: Kevin Barraclough
Journal: BMJ (2001)

I am lucky in that many of my closest friends are really famous people. I first met Johnson on my elective in British Columbia. It was otherwise not a good time in my life. My father had recently died, I had split up with my girlfriend, and the Canadians didn't believe in alcohol. The winter had set in early in the Rockies and I was alone in a small, snowed-in hospital house.

Luckily, I had been introduced to …
Transgenic mice expressing the Sh ble bleomycin resistance gene are protected against bleomycin-induced pulmonary fibrosis.
Authors: Jérôme Weinbach, Anne Camus, Jacqueline Barra, Patrick Dumont, Monique Julian, Suzy Cros, Charles Babinet, Gérard Tiraby
Journal: Cancer Research (1996)

Despite the high efficiency of bleomycin (BLM) as a chemotherapeutic agent against various carcinomas, the potentially lethal and chronic fibrotic response of the lung is a major dose-limiting side effect. Here, we explore the possibility of a direct inhibition of lung tissue injury by in vivo expression of the actinomycetes BLM resistance protein Sh ble. Transgenic mice expressing the Sh ble gene under the control of a composite viral promoter were produced after introduction of the transgene into D3 ES cells. The protein was detected at high level in lungs, spleen, and kidney. We then assessed its ability to modulate the BLM-induced fibrotic response in the transgenic mice in comparison with C57BL/6 and 129/Sv parental mice. Cumulative doses of 300, 400, or 500 mg/kg BLM were administered either by i.p. or s.c. repeated injections in the different strains. Transgenic mice were shown to be clearly less sensitive to BLM toxicity, as assessed by lung histology. The pulmonary hydroxyproline content in the treated transgenic mice was close to its baseline level, whereas it was up to 50% higher than the control level in C57BL/6 and 129/Sv parental mice. These observations are consistent with the hypothesis that a resistance gene specifically expressed in lungs may prevent the BLM-induced inflammation.
Increased expression of interleukin-23 p19 mRNA in erythema nodosum-like lesions of Behçet’s disease
Authors: W. Lew, J.Y. Chang, J.Y. Jung, D. Bang
Journal: British Journal of Dermatology (2008)

Journal Article Increased expression of interleukin‐23 p19 mRNA in erythema nodosum‐like lesions of Behçet's disease Get access W. Lew, W. Lew Department of Dermatology and Cutaneous Biology Research Institute, Yonsei University College of Medicine, 134 Shinchon‐Dong, Seodaemoon‐Gu, Seoul 120‐752, Korea Search for other works by this author on: Oxford Academic Google Scholar J.Y. Chang, J.Y. Chang Department of Dermatology and Cutaneous Biology Research Institute, Yonsei University College of Medicine, 134 Shinchon‐Dong, Seodaemoon‐Gu, Seoul 120‐752, Korea Search for other works by this author on: Oxford Academic Google Scholar J.Y. Jung, J.Y. Jung Department of Dermatology and Cutaneous Biology Research Institute, Yonsei University College of Medicine, 134 Shinchon‐Dong, Seodaemoon‐Gu, Seoul 120‐752, Korea Search for other works by this author on: Oxford Academic Google Scholar D. Bang D. Bang Department of Dermatology and Cutaneous Biology Research Institute, Yonsei University College of Medicine, 134 Shinchon‐Dong, Seodaemoon‐Gu, Seoul 120‐752, Korea Correspondence: Dongsik Bang. E‐mail: dongsikbang@yumc.yonsei.ac.kr Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 158, Issue 3, 1 March 2008, Pages 505–511, https://doi.org/10.1111/j.1365-2133.2007.08403.x Published: 01 March 2008
Activity of the Type II JAK2 Inhibitor CHZ868 in B Cell Acute Lymphoblastic Leukemia
Authors: Shuo-Chieh Wu, Loretta S. Li, Nadja Kopp, Joan Montero, Bjoern Chapuy, Akinori Yoda, Amanda L. Christie, Huiyun Liu, Alexandra Christodoulou, Diederik van Bodegom, Jordy van der Zwet, Jacob V. Layer, Trevor Tivey, Andrew A. Lane, Jeremy A. Ryan, Samuel Y. Ng, Daniel J. DeAngelo, Richard M. Stone, David Steensma, Martha Wadleigh, Marian Harris, Emeline Mandon, Nicolas Ebel, Rita Andraos, Vincent Romanet, Arno Dölemeyer, Dario Sterker, Michael Zender, Scott J. Rodig, Masato Murakami, Francesco Hofmann, Frank Kuo, Michael J. Eck, Lewis B. Silverman, Stephen E. Sallan, Anthony Letai, Fabienne Baffert, Eric Vangrevelinghe, Thomas Radimerski, Christoph Gaul, David M. Weinstock
Journal: Cancer Cell (2015)
Studies on Ehrlich Ascites Cells Exposed to the Sodium Salt and Ethyl Ester of Heptyloxyacetic Acid-1-14C
Authors: Parvathi K. Basrur, Gordon F. Townsend
Journal: Cancer Research (1966)

Summary  Autoradiographic and cytologic studies were undertaken on Ehrlich ascites tumor cells exposed to ethyl heptyloxyacetate-1- 14 C and sodium heptyloxyacetate-1- 14 C. These ascites cells exposed to the water-soluble compound sodium heptyloxyacetate showed no changes from the controls, whereas those exposed to the lipid-soluble compound ethyl heptyloxyacetate exhibited a variety of changes, including stretching and clumping of metaphase chromosomes, followed by a mitotic suppression for approximately 48 hr after treatment. The autoradiographs of ethyl heptyloxyacetate-treated samples showed a maximum incorporation in the cells at 1 hr after treatment, whereas those of sodium heptyloxyacetate showed no accumulation of grains in the cells in any of the samples, suggesting either rapid breakdown in the peritoneal fluid or failure to cross the cell membrane.  The chromosome features of the modal cells in the control and sodium heptyloxyacetate-treated mice were identical, whereas all ethyl heptyloxyacetate-treated mice differed from the controls and from one another. The predominant cell types of all 6 ethyl heptyloxyacetate-treated mice exhibited hypotetraploid numbers.
Abstract 852: Conditional Overexpression Of Neuronal Nitric Oxide Synthase Is Cardioprotective In Ischemia-reperfusion
Authors: Natalie Burkard, Adam Rokita, Susann Kaufmann, Matthias Hallhuber, Claudia Gebhardt, Kai Hu, Ludwig Neyses, Lars Maier, Kai Schuh, Oliver Ritter
Journal: Circulation (2007)

Introduction: We previously demonstrated that conditional overexpression of the neuronal nitric oxide synthase (nNOS, NOS1) inhibited L-type Ca 2+ -channels. We now hypothesize that nNOS overexpression has an impact on myocardial contractility and acts cardioprotective after ischemia-reperfusion. Methods and results: We assessed cardiac function in the newly established transgenic mouse model with conditional, myocardial nNOS overexpression. NOS-activity (22 ± 1.5 vs. 29 ± 1μM /sec, n=18, p&lt;0.05) was significantly enhanced after nNOS overexpression. Co-immunoprecipitation experiments indicated interaction of nNOS with SR Ca 2+ ATPase and additionally with L-type Ca 2+ -channels in nNOS overexpressing animals. I ca,L (reduction of 40±6 rel. %, n=12, p&lt;0.05) as well as intracellular Ca 2+ -transients and fractional shortening in cardiomyocytes were clearly impaired in nNOS overexpressing mice (3.0 ± 0.4F/F 0 vs. 2.2 ± 0.2F/F 0 , n=13, p&lt;0.005 and 7.7 ± 1.3% vs. 3.8 ± 0.5%, n=13, p&lt;0.05). In vivo examinations of the nNOS overexpressing mice showed a decrease of +dp/dt max (reduction for 52 ± 17%, n=12, p&lt;0.05) as well as a reduced ejection fraction (43±5% vs. 63±9%, n=12, p&lt;0.05). Ischemia-reperfusion experiments showed a cardio-protective effect of nNOS overexpression (30 min post-ischemia, LVDP 20±6 in non-induced animals vs. 60±11 mmHg in nNOS overexpressing animals, n=6, p&lt;0.05). Discussion: In summary, we demonstrated that under basline conditions, conditional transgenic overexpression of nNOS resulted in a mild reduction of myocardial contractility, mainly due to inhibition of the L-type Ca 2+ -channel. In contrast, under pathophysiological conditions (i.e. ischemia-reperfusion) nNOS overexpression acts cardioprotective. These effects might be caused by a reduction of myocardial Ca 2+ -overload after reperfusion.
Naturally occurring CD4+ CD25+ FoxP3+ Treg cells are related to the absence of antigen induced airway obstruction in a guinea pig asthma model
Authors: Patricia Ramos-Ramírez, Olivia Tellez-Jimenez, Erasmo Martinez-Cordero, Eduardo Garcia-Zepeda, Fernando Gutierrez-Aguilar, Blanca Bazan-Perkins
Journal: European Respiratory Journal (2011)

Some allergic asthma individuals did not display airway obstruction after an anaphylactic challenge (dAOAC); however, the mechanism involved in this process is unknown, it has been suggested that regulatory T cells (Tregs) may be involved. We developed a model of airway obstruction-induced by antigenic challenge in guinea pig (GP) to elucidate the potential role of Tregs. In our model, the sensitized GP are intermittently challenged with the antigen (ovalbumin, OA; applied every 10 days). We found two groups of GP ones that showed dAOAC and ones that did not. Then, we evaluated the antigen-induced airway obstruction and hyperresponsiveness (HR) to histamine and identified the population of Tregs in the bronchoalveolar lavage (BAL) in GP after three and six OA challenges. Controls received saline solution instead of OA. From the first challenge, GP that dAOAC showed a transient response and developed of HR at third and sixth challenges. In GP that did not dAOAC HR was observed at third but not at sixth challenge. The total number of cells that produced TGF-β1 and IL-10 in BAL were similar to controls in all groups. In GP that dAOAC, CD4+CD25+Foxp3+ T cells (nTreg) numbers were reduced in BAL in comparison to controls and GP that did not dAOAC. The number of inducible regulatory T cells (iTreg) that produced IL-10 was similar to controls in all groups, while iTregs that produced TGF-β1 increased only in the group of GP that did not dAOAC on the sixth challenge. We suggests that nTregs might play an important role in suppression of dAOAC and that probably iTregs that produce TGF-β1 are involved in the attenuation of HR in this asthma model.
Abstract 13796: Quantitative Measurement of Cross sectional Area of Small Pulmonary Vessels Using High-resolution Ct in Chronic Thromboembolic Pulmonary Hypertension
Authors: Toshihiko Sugiura, Nobuhiro Tanabe, Naoko Kawata, Yukiko Matsuura, Hajime Kasai, Ayako Shigeta, Seiichiro Sakao, Yasunori Kasahara, Kouichiro Tatsumi
Journal: Circulation (2014)

Background: It is generally recognized that there is narrowing and diminution of the small vessels on pulmonary angiography in patients with chronic thromboembolic pulmonary hypertension (CTEPH). Previous studies have shown that these vascular alterations could be assessed by the cross-sectional area of small pulmonary vessels (CSA) on high-resolution CT (HRCT) in patients with COPD. However, it is unknown whether there is a correlation between CSA and hemodynamics in patients with CTEPH. Aims: We retrospectively evaluated the relationship between the CSA on HRCT and hemodynamics measured by right heart catheterization (RHC). Materials and Methods: 61 patients (61±12 yrs, 13 male) with proven CTEPH underwent non-enhanced 64-slice HRCT (Aquilion ONE, Toshiba) and RHC. The HRCT images with 0.5 mm section thickness and 10 mm spacing were selected from all of the CT images in each patient. Using a semiautomatic image-processing program (Image J), CSA less than 5mm2 and 5-10mm2 , and total lung area were measured, and the percentage of the total CSA less than 5mm2 and 5-10mm2 for the lung area (%CSA&lt;5 and %CSA5-10, respectively) were calculated. The correlations of %CSA with hemodynamics measured by RHC were evaluated. Results: Mean pulmonary arterial pressure (mPAP) and pulmonary vascular resistance (PVR) from RHC were 41±9 mmHg and 8.3±3.0 Wood Units, respectively. %CSA&lt;5 and %CSA5-10 were 1.095±0.166% and 0.447±0.093 %, respectively. The correlation coefficients of %CSA&lt;5 with mPAP and PVR were -0.45 (P&lt;0.001) and -0.64 (P&lt;0.001), respectively. The correlation coefficients of %CSA5-10 with mPAP and PVR were -0.20 (P=0.1) and -0.38 (P=0.002), respectively. Conclusions: This study suggests that %CSA&lt;5 measured on HRCT is inversely correlated with PVR and can be used to evaluate hemodynamics in CTEPH subjects.
Association Between Weekend Discharge and Hospital Readmission Rates Following Major Surgery
Authors: Jordan M. Cloyd, Joy Chen, Yifei Ma, Kim F. Rhoads
Journal: JAMA Surgery (2015)

Although evidence suggests worse outcomes for patients admitted to the hospital on a weekend, to our knowledge, no previous studies have investigated the effects of weekend discharge.To determine whether weekend discharge would be associated with an increased rate of 30- and 90-day hospital readmission.Retrospective review of discharge abstracts from the California Office of State Health Planning and Development from 2012 identifying all patients who underwent abdominal aortic aneurysm (AAA) repair, colectomy, total hip arthroplasty, and pancreatectomy. This study was conducted from January to December 2012.Thirty- and 90-day readmission rates were compared between patients discharged on a weekend vs weekday.Of 128 057 patients, 5225 patients (4.1%) underwent AAA repair; 29 388 (22.9%), colectomy; 91 168 (71.2%), hip replacement; and 2276 (1.8%), pancreatectomy. Overall, 29 883 (23.3%) were discharged on a weekend. Although there were no significant differences with respect to sex, age, race/ethnicity, insurance status, or type of admission, patients discharged on a weekend had shorter length of stays and were less often discharged to a skilled nursing facility. Overall, the 30-day readmission rate was 9.4% after AAA repair, 13.6% after colectomy, 7.5% after hip replacement, and 16.3% after pancreatectomy. Hospital readmission rates were similar for those discharged on a weekend vs weekday after AAA repair (8.8% vs 9.3%; P = .55) and pancreatectomy (17.5% vs 15.9%; P = .40). However, weekend discharge was associated with a lower 30-day readmission rate for patients undergoing colectomy (12.1% vs 14.1%; P < .001) and hip replacement (6.9% vs 7.7%; P < .001). On multivariable analysis, weekend discharge was inversely associated with readmission after colectomy (odds ratio [OR], 0.86; 95% CI, 0.79-0.93) but not AAA repair (OR, 0.93; 95% CI, 0.73-1.19), hip replacement (OR, 0.97; 95% CI, 0.91-1.03), or pancreatectomy (OR, 1.02; 95% CI, 0.76-1.36). Finally, a substantial percentage of 30-day readmissions occurred at a different hospital (AAA repair: 40.5%; colectomy: 25.8%; hip replacement: 32.5%; and pancreatectomy: 19.7%) compared with the index hospitalization. Similar results were seen for 90-day readmissions.Weekend discharge after major surgery is not associated with higher 30- or 90-day readmission rates.