Prostacyclin for Secondary Pulmonary Hypertension
Authors: Karamjit Kaur, Bernice Brown, Fred Lombardo
Journal: Annals of Internal Medicine (2000)

Letters18 January 2000Prostacyclin for Secondary Pulmonary HypertensionKaramjit Kaur, MD, Bernice Brown, MD, and Fred Lombardo, PharmDKaramjit Kaur, MDHoward University College of Medicine; Washington, DC 20059 (Kaur)Howard University College of Medicine; Washington, DC 20059 (Brown)Howard University College of Medicine; Washington, DC 20059 (Lombardo)Search for more papers by this author, Bernice Brown, MDHoward University College of Medicine; Washington, DC 20059 (Kaur)Howard University College of Medicine; Washington, DC 20059 (Brown)Howard University College of Medicine; Washington, DC 20059 (Lombardo)Search for more papers by this author, and Fred Lombardo, PharmDHoward University College of Medicine; Washington, DC 20059 (Kaur)Howard University College of Medicine; Washington, DC 20059 (Brown)Howard University College of Medicine; Washington, DC 20059 (Lombardo)Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-132-2-200001180-00019 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:We read with interest McLaughlin and colleague's report on the use of prostacyclin to treat secondary pulmonary hypertension (1). Primary causes of precapillary pulmonary hypertension in their series included congenital heart disease, collagen vascular disease, sarcoidosis, distal thromboembolic disease, and portopulmonary hypertension. Sickle cell disease is also a cause of secondary pulmonary hypertension (2, 3). During the cardiac catheterization diagnosis of pulmonary hypertension in four adult patients with sickle cell anemia, our cardiology colleague tested them for response to prostacyclin. The results are listed in the Table.Table. Pulmonary Vascular Resistance before and after Prostacyclin Infusion ...References1. McLaughlin VV, Genthner DE, Panella MM, Hess DM, Rich SH. Compassionate use of continuous prostacyclin in the management of secondary pulmonary hypertension: a case series. Ann Intern Med. 1999;130:740-3. LinkGoogle Scholar2. Sutton LL, Castro O, Cross DJ, Spencer JE, Lewis JF. Pulmonary hypertension in sickle cell disease. Am J Cardiol. 1994;74:626-8. CrossrefMedlineGoogle Scholar3. Castro O. Systemic fat embolism and pulmonary hypertension in sickle cell disease. Hematol Oncol Clin North Am. 1996;6:1289-303. CrossrefGoogle Scholar Author, Article, and Disclosure InformationAffiliations: Howard University College of Medicine; Washington, DC 20059 (Kaur)Howard University College of Medicine; Washington, DC 20059 (Brown)Howard University College of Medicine; Washington, DC 20059 (Lombardo) PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoCompassionate Use of Continuous Prostacyclin in the Management of Secondary Pulmonary Hypertension: A Case Series Vallerie V. McLaughlin , Diane E. Genthner , Maureen M. Panella , Dina M. Hess , and Stuart Rich Prostacyclin for Secondary Pulmonary Hypertension Vallerie V. McLaughlin and Stuart Rich Metrics Cited ByHemolytic-Anemia-Associated Pulmonary Hypertension: Sickle-Cell-Disease- and Thalassemia-Associated Pulmonary HypertensionLongitudinal follow up of elevated pulmonary artery pressures in children with sickle cell diseaseProtective effects of phosphodiesterase‐4 (PDE‐4) inhibition in the early phase of pulmonary arterial hypertension in transgenic sickle cell micePULMONARY HYPERTENSION IN SICKLE CELL DISEASE: Relevance to ChildrenLes traitements de l’hypertension artérielle pulmonaire à l’heure de la T2A. Recommandations du groupe de travail “Maladies vasculaires pulmonaires” de la Société de pneumologie de langue françaisePulmonary Complications of Sickle Cell AnemiaFlolan Infusion Interruption: A Lethal Complication during Venous Access 18 January 2000Volume 132, Issue 2Page: 165KeywordsHeart diseasesHypertensionInterstitial lung diseasesProstacyclinPulmonary hypertensionPulmonary vascular diseasesPulmonary vascular resistanceSarcoidosisSickle cell diseaseVascular diseases Issue Published: 18 January 2000 CopyrightCopyright © 2000 by American College of Physicians. All Rights Reserved.PDF DownloadLoading ...