Reversible Myopathy after Statin Therapy in Patients with Normal Creatine Kinase Levels
Authors: William E. Bennett, Almond J. Drake, KM Mohamed Shakir
Journal: Annals of Internal Medicine (2003)

Letters4 March 2003Reversible Myopathy after Statin Therapy in Patients with Normal Creatine Kinase LevelsWilliam E. Bennett, MD, Almond J. Drake III, MD, and KM Mohamed Shakir, MDWilliam E. Bennett, MDNational Naval Medical Center; Bethesda, MD 20889 (Bennett, Drake III, Shakir)Search for more papers by this author, Almond J. Drake III, MDNational Naval Medical Center; Bethesda, MD 20889 (Bennett, Drake III, Shakir)Search for more papers by this author, and KM Mohamed Shakir, MDNational Naval Medical Center; Bethesda, MD 20889 (Bennett, Drake III, Shakir)Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-138-5-200303040-00021 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:The brief communication by Phillips and colleagues (1) parallels what we have observed at the National Naval Medical Center in Bethesda, Maryland, where we recently withdrew 5 patients from statin therapy secondary to severe muscle cramps. These patients started receiving therapy for elevated levels of low-density lipoprotein cholesterol and met all National Cholesterol Education Program guidelines for initiation of pharmacologic therapy. They had normal baseline renal and hepatic function and did not take any drugs that are known to interact with statins (2). All 5 patients received dietary counseling and simvastatin in daily doses of 20 to ...References1. Phillips PS, Haas RH, Bannykh S, Hathaway S, Gray NL, Kimura BJ, . Statin-associated myopathy with normal creatine kinase levels. Ann Intern Med. 2002;137:581-5. [PMID: 12353945] LinkGoogle Scholar2. Boger RH. Drug interactions of the statins and consequences for drug selection. Int J Clin Pharmacol Ther. 2001;39:369-82. [PMID: 11563683] CrossrefMedlineGoogle Scholar Author, Article, and Disclosure InformationAffiliations: National Naval Medical Center; Bethesda, MD 20889 (Bennett, Drake III, Shakir) PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoStatin-Associated Myopathy with Normal Creatine Kinase Levels Paul S. Phillips , Richard H. Haas , Sergei Bannykh , Stephanie Hathaway , Nancy L. Gray , Bruce J. Kimura , Georgirene D. Vladutiu , John D.F. England , and Metrics Cited ByMuscle Toxicity of Drugs: When Drugs Turn Physiology into PathophysiologyNeuromuscular Effects of Rocuronium Bromide in Patients in Statin Therapy for at least Three MonthsPrevalence and risk factors of muscle complications secondary to statinsDrugs Causing Muscle DiseaseMetabolic, drug-induced, and other non-inflammatory myopathiesMedicationsMyotoxicity associated with lipid-lowering drugsSTATIN MYOPATHIESStatin-associated myopathy with normal creatine kinase levels. Case report from a Norwegian familyPotential Adverse Effects of Statins on Muscle 4 March 2003Volume 138, Issue 5Page: 436-437KeywordsCreatine kinaseDrugsEnzymesHypercholesterolemiaMusclesMyalgiaResearch laboratoriesRhabdomyolysisStatinsThyroid ePublished: 4 March 2003 Issue Published: 4 March 2003 CopyrightCopyright © 2003 by American College of Physicians. All Rights Reserved.PDF DownloadLoading ...