THE PHYSIOLOGIC AND CLINICAL SIGNIFICANCE OF ERYTHROPOIETIN
Authors: C W GURNEY, L O JACOBSON, E GOLDWASSER
Journal: Annals of Internal Medicine (1958)

Article1 August 1958THE PHYSIOLOGIC AND CLINICAL SIGNIFICANCE OF ERYTHROPOIETINCLIFFORD W. GURNEY, M.D., LEON O. JACOBSON, M.D., F.A.C.P., EUGENE GOLDWASSER, Ph.D.CLIFFORD W. GURNEY, M.D.Search for more papers by this author, LEON O. JACOBSON, M.D., F.A.C.P.Search for more papers by this author, EUGENE GOLDWASSER, Ph.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-49-2-363 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptUntil recently it was generally agreed that low oxygen tension in the bone marrow constituted a direct stimulus for red cell production. This view was challenged by many investigators whose studies demonstrated that the rate of erythropoiesis, both in vivo1, 2 and in marrow cultures,3, 4 was independent of changes in oxygen tension. Clearly an alternate hypothesis was needed.In 1906 Carnot and Deflandre described the erythropoietic-stimulating properties of serum of anemic rabbits by injecting this serum into normal rabbits, thereby obtaining increased reticulocyte and hemoglobin values in the animals that received the anemic serum.5This experimental procedure was employed...Bibliography1. GrantRoot WCWS: The relation of oxygen in bone marrow blood to post-hemorrhagic erythropoiesis, Am. J. Physiol. 150: 618, 1947. CrossrefMedlineGoogle Scholar2. BerkBurchenalWoodCastle LJHTWB: Oxygen saturation of sternal marrow blood with special reference to pathogenesis of polycythemia vera, Proc. Soc. Exper. Biol. and Med. 69: 316, 1948. CrossrefMedlineGoogle Scholar3. RosinRachmilewitz AM: Studies on marrow in vitro. III. The effect of anoxia and hyperoxia on explanted bone marrow, Blood 3: 165, 1948. CrossrefMedlineGoogle Scholar4. Thomas ED: In vitro studies of erythropoiesis. II. 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Gardner FH: The use of cobaltous chloride in anemia associated with chronic renal disease, J. Lab. and Clin. Med. 41: 56, 1953. MedlineGoogle Scholar28. WeinsaftBernstein PPLH: Treatment of certain refractory anemias, Am. J. M. Sc. 230: 264, 1955. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Chicago, Illinois*Presented at the Thirty-ninth Annual Session of the American College of Physicians, Atlantic City, New Jersey, April 30, 1958.From the Argonne Cancer Research Hospital, U. S. Atomic Energy Commission, and the Departments of Medicine and Biochemistry, The University of Chicago.Requests for reprints should be addressed to Clifford W. Gurney, M.D., 950 East Fifty-ninth Street, Chicago 37, Illinois. 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LONG, M.S.STUDIES OF ERYTHROPOIETIN: THE HORMONE REGULATING RED CELL PRODUCTIONPolycythemia in Renal Carcinoma 1 August 1958Volume 49, Issue 2Page: 363-370KeywordsBlood plasmaBone marrowHemoglobinHormonesHospital medicineNephritisOxygenPolycythemiaRabbitsReticulocytes ePublished: 1 December 2008 Issue Published: 1 August 1958 PDF downloadLoading ...