THE DIAMIDINES IN CHEMOTHERAPY: A SURVEY OF RECENT DEVELOPMENTS WITH A NOTE REGARDING THERAPEUTIC TRIALS IN PATIENTS WITH RHEUMATOID ARTHRITIS
Authors: Edward F. Rosenberg
Journal: Annals of Internal Medicine (1946)

Article1 November 1946THE DIAMIDINES IN CHEMOTHERAPY: A SURVEY OF RECENT DEVELOPMENTS WITH A NOTE REGARDING THERAPEUTIC TRIALS IN PATIENTS WITH RHEUMATOID ARTHRITISEDWARD F. ROSENBERGEDWARD F. ROSENBERGSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-25-5-832 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptRecent advances in the field of therapy for protozoal diseases, though not so spectacular as the discoveries of sulfonamides and penicillin, have nevertheless been significant and deserving of wider attention than they have yet received in this country.The most interesting and most promising of these discoveries concerns the parasiticidal effects of the family of strongly basic organic preparations known as diamidines. These compounds have been shown to possess value in treatment of leishmaniasis and trypanosomiasis, diseases which affect many inhabitants of great portions of the earth and cause endless suffering. Compounds of this group also possess bactericidal properties, and...Bibliography1. ADAMS AR: Studies in chemotherapy. XXVI. A case of Indian kala-azar treated with 4:4′ diamidinodiphenoxy pentane, Ann. Trop. Med., 1941, xxxv, 53. CrossrefGoogle Scholar2. ADAMSYORKE ARW: Studies in chemotherapy. XXIII. A case of Indian kala-azar treated with 4:4′ diamidino stilbene, Ann. Trop. Med., 1939, xxxiii, 323. CrossrefGoogle Scholar3. ADAMSYORKE ARW: Studies in chemotherapy. XXV. A second case of Indian kala-azar treated with 4:4′ diamidino stilbene, Ann. Trop. Med., 1940, xxxiv, 173. CrossrefGoogle Scholar4. ADLERTCHERNOMORETZ SI: The action of 4:4′ diamidino stilbene on Leishmania donovani in the Syrian hamster, Circetus auratus , Ann. Trop. Med., 1939, xxxiii, 313. CrossrefGoogle Scholar5. ADLERRACHMILEWITZ SM: A note on the treatment of a case of Leishmania infantum with 4:4′ diamidino stilbene, Ann. Trop. Med., 1939, xxxiii, 327. CrossrefGoogle Scholar6. BOWESMAN C: A short report on the use of 4:4′ diamidino stilbene in the treatment of human sleeping sickness, Ann. Trop. Med., 1940, xxxiv, 217. CrossrefGoogle Scholar7. CARMICHAEL J: Treatment of canine babesiasis by 4:4′ diamidino diphenoxy propane, Ann. Trop. Med. and Hyg., 1941, xxxv, 191. Google Scholar8. DAUBNEYHUDSON RJR: Action of two aromatic diamidines on Trypanosoma congolense infections in cattle with a note on delayed poisoning by 4:4′ diamidino diphenoxy pentane, Ann. Trop. Med., 1941, xxxv, 175. CrossrefGoogle Scholar9. DAUBNEYHUDSON RJR: A note on the chemotherapeutic action of 4:4′ diamidino stilbene in Babesia canis infections of domestic animals, Ann. Trop. Med. and Hyg., 1941, xxxv, 187. Google Scholar10. DEVINE J: Studies in chemotherapy; changes in the blood produced by administration of 4:4′ diamidino stilbene, Ann. Trop. Med., 1940, xxxiv, 67. CrossrefGoogle Scholar11. FULLER AT: Antibacterial actions and chemical constitution in long chain aliphatic bases, Biochem. Jr., 1942, xxxvi, 548. CrossrefGoogle Scholar12. FULTON JD: The course of Plasmodium relictum infection in canaries and the treatment of bird and monkey malaria with synthetic bases, Ann. Trop. Med., 1940, xxxiv, 53. CrossrefGoogle Scholar13. FULTONYORKE JDW: Increased toxicity of old solutions of stilbamidine, Ann. Trop. Med., 1942, xxxvi, 134. CrossrefGoogle Scholar14. GILBERT SW: Pentamidine in treatment of late cases of sleeping sickness, Trans. Roy. Soc. Trop. Med. and Hyg., 1943, xxxvi, 353. CrossrefGoogle Scholar15. HALLGROSS MHCD: Propamidine at an E. M. S. Hospital, Lancet, 1943, i, 140. Google Scholar16. HARDING RD: A trial with 4:4′ diamidino stilbene in the treatment of sleeping sickness at Gadau, Northern Nigeria, Ann. Trop. Med., 1940, xxxiv, 101. CrossrefGoogle Scholar17. HAWKINGSMILES FJ: The distribution of 4:4′ diamidino stilbene in trypanosomes and mice as shown by fluorescence, Ann. Trop. Med., 1941, xxxv, 45. CrossrefGoogle Scholar18. HENRYGRINDLEY AJDN: Fluorescence and absorption of stilbamidine and its estimation in biological fluids, Ann. Trop. Med., 1942, xxxvi, 102. CrossrefGoogle Scholar19. HUMPHREYS RM: Two cases of oral pharyngeal leishmaniasis treated with pentamidine, Ann. Trop. Med., 1942, xxxvi, 9. CrossrefGoogle Scholar20. KIRKSATI RMG: Notes on some cases of Sudan kala-azar treated with 4:4′ diamidino stilbene, Ann. Trop. Med., 1940, xxxiv, 83. CrossrefGoogle Scholar21. LAWSON TL: Trypanosomiasis treated with "pentamidine," Lancet, 1942, ii, 480. CrossrefGoogle Scholar22. LOURIEYORKE EMW: Studies on chemotherapy. XXI. The trypanocidal action of certain aromatic diamidines, Ann. Trop. Med., 1939, xxxiii, 289. CrossrefGoogle Scholar23. MORLEYBENTLEY GHJP: Propamidine in burns, Lancet, 1943, i, 138. CrossrefGoogle Scholar24. MCCOMASMARTIN GNH: Trypanosomiasis treated with pentamidine: A fatal case, Lancet, 1944, i, 338. CrossrefGoogle Scholar25. MCINDOETILLEY AHAR: Propamidine in chronic streptococcal infection of raw surfaces, Lancet, 1943, i, 136. CrossrefGoogle Scholar26. MCLETCHIE JL: The treatment of early cases of Nigerian trypanosomiasis with 4:4′ diamidino stilbene, Ann. Trop. Med., 1940, xxxiv, 217. Google Scholar27. NAPIERSEN GUPTA LEPC: Diamidino stilbene in the treatment of kala-azar, Ann. Trop. Med. and Hyg., 1941, xliv, 45. Google Scholar28. NAPIERSEN GUPTA LEPC: A peculiar neurological sequel to administration of 4:4′ diamidino diphenyl ethylene (M & B 744), Indian Med. Gaz., 1942, lxxvii, 71. Google Scholar29. SAUNDERS GF: Preliminary report on the treatment of sleeping sickness by 4:4′ diamidino diphenoxy pentane, Ann. Trop. Med., 1941, xxxv, 169. CrossrefGoogle Scholar30. SOMERS RB: Kala-azar treated with 4:4′ diamidino stilbene, Lancet, 1944, i, 531. CrossrefGoogle Scholar31. SEN GUPTA PC: Observations on the neuropathic sequel of diamidino-stilbene therapy in kala-azar, Indian Med. Gaz., 1943, lxxviii, 537. Google Scholar32. THROWERVALENTINE WRFC: Propamidine in chronic wound sepsis, Lancet, 1943, i, 133. CrossrefGoogle Scholar33. VAN HOOFHENRARDPEEL LCE: Pentamidine in prevention and treatment of trypanosomiasis, Trans. Roy. Soc. Trop. Med. and Hyg., 1944, xxxvii, 271. CrossrefGoogle Scholar34. WINGFIELD AL: 4:4′ diamidino stilbene in the treatment of kala-azar, Ann. Trop. Med., 1941, xxxv, 55. CrossrefGoogle Scholar35. YORKE W: Recent work on the chemotherapy of protozoal infections, Trans. Roy. Soc. Trop. Med. and Hyg., 1940, xxxiii, 463. CrossrefGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: *Received for publication February 18, 1946.From the Army Rheumatism Center, Army and Navy General Hospital, Hot Springs, Arkansas. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byUsing Genome Sequence to Enable the Design of Medicines and Chemical ProbesRHEUMATISM AND ARTHRITIS REVIEW OF AMERICAN AND ENGLISH LITERATURE OF RECENT YEARS (TENTH RHEUMATISM REVIEW)* Part IIWILLIAM D. ROBINSON, M.D., F.A.C.P., EDWARD W. BOLAND, M.D., F.A.C.P., JOSEPH J. BUNIM, M.D., F.A.C.P., DARRELL C. CRAIN, M.D., F.A.C.P., EPHRAIM P. ENGLEMAN, M.D., F.A.C.P., WALLACE GRAHAM, M.D., F.R.C.P. (C), L. MAXWELL LOCKIE, M.D., F.A.C.P., MAX M. MONTGOMERY, M.D., F.A.C.P., CHARLES RAGAN, M.D., F.A.C.P., MARIAN W. ROPES, M.D., F.A.C.P., EDWARD F. ROSENBERG, M.D., F.A.C.P., CHARLEY J. SMYTH, M.D. 1 November 1946Volume 25, Issue 5Page: 832-844KeywordsChemotherapyLeishmaniasisPenicillinRheumatoid arthritisSulfonamideTrypanosomiasis ePublished: 1 December 2008 Issue Published: 1 November 1946 PDF downloadLoading ...