tbuckley/cabot-search huggingface dataset:
Philadelphia Chromosome in Human Multiple Myeloma&lt;xref ref-type="fn" rid="fn2"&gt;2&lt;/xref&gt;
Authors: H Van Den Berghe, A Louwagie, A Broeckaert-Van Orshoven, G David, R Verwilghen, J L Michaux, G Sokal
Journal: JNCI Journal of the National Cancer Institute (1979)

Four patients with multiple myeloma in whom a Ph1 chromosome was found were described; 1 patient had a (9;22) translocation, 2 had no evidence of a translocation, and 1 had a complex translocation (3;8;22). Ph1 chromosomes with standard (9;22) or with unusual translocations were recently found in various myeloproliferative disorders (other than chronic myelogenous leukemia) and in acute lymphoblastic leukemia. These findings point to the genesis of a Ph1 chromosome in diseases other than chronic myclogenous leukemia and other myeloproliferative disorders.
Pigment Epithelium–derived Factor in Idiopathic Pulmonary Fibrosis
Authors: Gregory P. Cosgrove, Kevin K. Brown, William P. Schiemann, Amanda E. Serls, Jane E. Parr, Mark W. Geraci, Marvin I. Schwarz, Carlyne D. Cool, G. Scott Worthen
Journal: American Journal of Respiratory and Critical Care Medicine (2004)

Pigment epithelium-derived factor (PEDF) is a 50-kD protein with angiostatic and neurotrophic activities that regulates vascular development within the eye. PEDF expression was increased in the lungs of patients with idiopathic pulmonary fibrosis (IPF) based on microarray analyses. Angiogenesis has been implicated in the pathogenesis of fibrotic lung diseases, we therefore hypothesized that regional abnormalities in vascularization occur in IPF as a result of an imbalance between PEDF and vascular endothelial growth factor. We demonstrated that vascular density is regionally decreased in IPF within the fibroblastic foci, and that within these areas PEDF was increased, whereas vascular endothelial growth factor was decreased. PEDF colocalized with the fibrogenic cytokine, transforming growth factor (TGF)-β1, particularly within the fibrotic interstitium and the fibroblastic focus, and prominently within the epithelium directly overlying the fibroblastic focus. This suggested that TGF-β1 might regulate PEDF expression. Using 3T3-L1 fibroblasts and human lung fibroblasts, we showed that PEDF was indeed a TGF-β1 target gene. Collectively, our findings implicate PEDF as a regulator of pulmonary angiogenesis and an important mediator in IPF.
Immunity to a 3-Methylcholanthrene-Induced Fibrosarcoma in the C57BL/6 Mouse: In Vivo Analysis by the Adoptive Tumor Neutralization Test&lt;xref ref-type="fn" rid="FN2"&gt;2&lt;/xref&gt;
Authors: M F Poupon, G Lespinats, J P Kolb, B Payelle
Journal: JNCI Journal of the National Cancer Institute (1979)

Analyses of the adoptive tumor neutralization test (modified Winn test) in C57BL/6 mice made immune to a 3-methylcholantheene-induced fibrosarcoma showed that the reaction was mediated by a thymus-derived lymphocyte, it was tumor-specific, and the resistance of the immunized donor mouse to the challenge was strongly correlated with the protection of the recipient mouse. Proliferation of immune cells and close contact between tumor cells and immune T-cells were required. The hypothesis of a participation of the recipient in the reaction was considered because of the lack of adoptive protection of pangenic nude mice.
Prognostic Value of the SYNTAX Score in Patients With Acute Coronary Syndromes Undergoing Percutaneous Coronary Intervention
Authors: Tullio Palmerini, Philippe Genereux, Adriano Caixeta, Ecaterina Cristea, Alexandra Lansky, Roxana Mehran, George Dangas, Dana Lazar, Raquel Sanchez, Martin Fahy, Ke Xu, Gregg W. Stone
Journal: Journal of the American College of Cardiology (2011)
Evolutionary dynamics of the enhancer region of even-skipped in Drosophila.
Authors: M Z Ludwig, M Kreitman
Journal: Molecular Biology and Evolution (1995)

We report findings on naturally occurring variation in the regulatory region of even-skipped in Drosophila. This pair-rule gene encodes a homeobox-containing transcription factor, is expressed as a series of seven transverse stripes in developing embryos, and defines parasegmental boundaries. The 5' flanking region of the gene contains a 671-bp enhancer governing stripe 2 expression. The stripe 2 enhancer contains multiple binding sites for four transcription factors that provide positional information in developing blastoderm, the positive regulators bicoid and hunchback and the repressors giant and Kruppel. The study compares polymorphism and divergence in Drosophila melanogaster and Drosophila simulans for the enhancer region, the spacer between the enhancer and the transcription start site, the untranslated leader, the first exon and the intron of eve. Contrary to expectations, we find a relatively high level of variation in the stripe 2 enhancer region, including point substitutions and insertion/deletions in binding sites, and a comparable level of variation in the other noncoding regions. The patterns of variation and divergence within the enhancer region and between regions of the locus fit a model of neutral molecular evolution. We suggest that the multiplicity of binding sites in the enhancer provides a redundancy in function that allows flexibility in the sequence requirements and structural design of the promoter.
Solitary bronchial amyloid presenting with haemoptysis
Authors: SM Tariq, D Morrison, K McConnochie
Journal: European Respiratory Journal (1990)

Pulmonary amyloidosis can be classified into tracheobronchial diffuse alveolar-septal and nodular parenchymal forms. Tracheobronchial amyloidosis can be further subdivided into diffuse and focal varieties. The latter is rare. We report a patient with a focal intrabronchial deposit of amyloid who presented with haemoptysis. The haemoptysis ceased following bronchoscopic removal of this deposit.
Tuberculosis among health care workers
Authors: Maja Zakoska, Biljana Ilievska Poposka, Ismail Vaiti
Journal: European Respiratory Journal (2012)

Aim of this study is to assess the occupational risk and characteristic of tuberculosis (TB) among health care workers (HCWs) employed at health institutions in Republic of Macedonia from 2007-2011 year. The diagnosis of TB was based on clinical and radiological findings and confirmed bacteriological or histological. The data were from National TB registry.  Results: From total number of 16 HCWs with TB (9 nurses, 3 stomatologists. 1 chemist9sassistant and 3 other employed), 13(81.3 %) were female. The majority of them 5 (31.1%) were on the age of 25-34 years. The pulmonary TB were 9(56.3%), extra pulmonary TB 4(25%) and both pulmonary and extra pulmonary TB 3(18.7%). The SS+ and culture + were 9(56.3%), only culture + were 3(18.7%) and 4 (25%) extra pulmonary TB have histological confirmation. The all 12 (75%) were sensitive on first line drugs. The all registered HCWs with TB were success treated, 6(37.5%) as cured and 10(62.5%) as treatment completed. Between those patients were not employed in institutions for lung diseases and tuberculosis because the infection control is better than in other health institutions.
High-dose etoposide and melphalan, and autologous bone marrow transplantation for patients with advanced Hodgkin's disease: importance of disease status at transplant.
Authors: M Crump, A M Smith, J Brandwein, F Couture, H Sherret, D M Sutton, J G Scott, J McCrae, C Murray, D Pantalony
Journal: Journal of Clinical Oncology (1993)

PURPOSE To evaluate an intensive therapy regimen of high-dose etoposide and melphalan and autologous bone marrow transplantation (ABMT) in advanced Hodgkin's disease; and to determine possible prognostic factors that predict for long-term disease-free survival (DFS). PATIENTS AND METHODS Seventy-three patients with advanced Hodgkin's disease who had failed to achieve remission with front-line chemotherapy (n = 16) or who had relapsed (n = 57) were treated with high-dose etoposide 60 mg/kg and melphalan 160 mg/m2 and ABMT. Previous therapy included mechlorethamine, vincristine, procarbazine, and prednisone (MOPP) alternating with doxorubicin, bleomycin, vinblastine, and dacarbazine (ABVD), or hybrid MOPP/ABV. All patients received pretransplant cytoreduction with conventional-dose salvage chemotherapy and 40 also received pretransplant extended-field radiation to areas of bulky nodal disease (&gt; 5 cm). RESULTS Response to high-dose etoposide and melphalan was determined at 3 months post-ABMT. The complete response (CR) rate was 75% (95% confidence interval [CI], 64% to 84%), including 35 of 50 patients with measurable disease before ABMT (70%; 95% CI, 60% to 86%). There were three early deaths (septicemia) and four late deaths (three interstitial pneumonitis, one intracerebral hemorrhage). Actuarial DFS is 38.6% at 4 years. Multivariate regression analysis showed that disease status at the time of ABMT (no evidence of disease [NED], nonbulky residual disease [NBRD], or bulky disease) was the most important factor determining DFS: 68% of those transplanted with NED versus 26% for patients with NBRD and 0% for bulky disease (P = .0002, log-rank test). Relapse in a previous radiation field was the only other significant prognostic factor. CONCLUSION Etoposide and melphalan is an effective and well-tolerated intensive therapy regimen in advanced Hodgkin's disease. Patients in complete remission after conventional-dose salvage therapy transplanted with this regimen enjoy superior long-term DFS.
Nuclear Magnetic Resonance Study of Human Bone Marrows From Patients With Leukemia, Anemia, and Myeloma and From Normal Donors
Authors: Tadashi Kagimoto, Yamasaki Masaki, Yoshimasa Morino, Kazuyuki Akasaka, Susumu Kishimoto
Journal: JNCI Journal of the National Cancer Institute (1977)

Journal Article Nuclear Magnetic Resonance Study of Human Bone Marrows From Patients With Leukemia, Anemia, and Myeloma and From Normal Donors Get access Tadashi Kagimoto, Tadashi Kagimoto Search for other works by this author on: Oxford Academic PubMed Google Scholar Yamasaki Masaki, Yamasaki Masaki Search for other works by this author on: Oxford Academic PubMed Google Scholar Yoshimasa Morino, Yoshimasa Morino Search for other works by this author on: Oxford Academic PubMed Google Scholar Kazuyuki Akasaka, Kazuyuki Akasaka Search for other works by this author on: Oxford Academic PubMed Google Scholar Susumu Kishimoto Susumu Kishimoto Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 59, Issue 2, August 1977, Pages 355, https://doi.org/10.1093/jnci/59.2.335 Published: 01 August 1977 Article history Received: 10 December 1976 Accepted: 25 February 1977 Published: 01 August 1977
Outpatient follow up of discharges following acute hospital admission requiring non-invasive ventilation (NIV)
Authors: Sukhneet Randhawa, Helena Boryslawskyj, Santana-Vaz Natasha, Sharma Pooja, Biman Chakraborty, Jumaa Bwika, Manahil Abdelhalim, Kirstie Morley, Rahul Mukherjee
Journal: European Respiratory Journal (2014)

Introduction   Outpatient follow up rates are a national metric for acute NIV services in the UK (Davies M.  Adult NIV Audit report 2012 .  BTS Reports  2012. 4 (3): 9-10.) Also, the number of re-admissions is a determinant of health status. We analyse the proportion of live discharges that were offered respiratory follow up within 6 months of all patients requiring Acute NIV during the calendar year 2009 and first 6 months of 2013 at our 709-bedded acute Central England hospital.   Methods   Information was sought from the acute NIV database maintained continuously since 2004, electronic discharge summaries and clinic letters. The chi-squared test was performed for statistical significance of differences.   Results   The proportion of unique live discharges offered a follow up appointment at the time of discharge improved from 57% (62/107) in 2009 to 80% (36/45) in 2013: p=0.009. The proportion of patients attending follow-up appointments increased from 40% (42/107) in 2009 to 58% (26/45) in 2013: p=0.036, confirming a statistically significant improvement. The number of acute NIV re-admissions slightly dropped between 2009 and 2013.   Conclusions   The increase in the number of patients attending follow up is likely due to the increase in the number being offered follow up, an improvement explained by upskilling of the multidisciplinary team and introduction of the rapid access 9HUB9 clinic in Oct 2011. The responsive HUB would also be a plausible explanation for the slight drop in acute NIV re-admissions between the 2 periods, reflecting its ability to offer a safety net for patients who are often recurrent re-admissions and keep them well in the community.
Multidrug resistant acinetobacter baumannii in ventilator associated pneumonia: Prevalence and predictors of mortality
Authors: Basima Almomani, Rawan Al-Gharaibeh, Fatimah Al-Mahasneh, Shaher Samrah
Journal: European Respiratory Journal (2014)

Background:  Acinetobacter baumannii  ( A. baumannii ) is one of the most challenging pathogens in Ventilator-associated pneumonia (VAP) patients as the treatments are limited to only a few antibiotics. Worldwide, the emergence of multidrug resistant  A. baumannii  (MDR-AB) strains has become increasingly common in hospitals and associated with significant impact on patient9s survival and hospital cost.  Aims and objectives: To determine the prevalence and predictors of mortality for MDR-AB in patients with VAP.  Methods: A retrospective, observational study was conducted at King Abdullah University Hospital, to collect data from patients with MDR-AB VAP from 1 st  January 2007 to 31 st  June 2013. After having obtained ethical approval, the list of candidate patients were retrieved using computerized database in the hospital.  Results: Of the 121 patients diagnosed with  A. baumannii  VAP, 98.3% (119/121) were infected with MDR-AB, and thus were included in the final detailed analysis. Multivariate analysis adjusted for possible confounders (age and gender variables) revealed that only lower number of definitive therapy (OR=0.451, 95% CI: 0.281–0.726, p=0.001) was an independent predictors of 14-days mortality in MDR-AB VAP patients. In addition, using ipratropium bromide/ albuterol sulfate during mechanical ventilation (OR=0.152, 95% CI: 0.031–0.733, p=0.019) was identified as an independent factor associated with low mortality.  Conclusions: Identification of prognostic factors of mortality would be a reliable tool for early detection and guiding empirical therapy.
Does single dose salmeterol affect exercise capacity in asthmatic men?
Authors: W Robertson, J Simkins, SP O'Hickey, S Freeman, RM Cayton
Journal: European Respiratory Journal (1994)

The aim of this study was to investigate whether the long-acting beta-agonist salmeterol affects athletic performance in patients with asthma. The effect of 50 micrograms salmeterol on the cardiorespiratory responses to a progressive maximal cycle exercise test and on endurance capacity (defined as the exercise duration at 70% maximum oxygen uptake), was compared with 200 micrograms salbutamol and a matched placebo in eight asthmatic men. Both salmeterol and salbutamol improved pre- and postexercise forced expiratory volume in one second (FEV1) for maximal and endurance exercise. Following active treatment, patients exercised from a significantly high baseline FEV1, with both salmeterol (3.58(1.16)l) (mean (SD)) and salbutamol (3.55(1.24)l) compared with placebo (3.29(1.35)l). Similar improvements preceded endurance exercise. Cardiorespiratory, haemodynamic or subjective responses to the progressive maximum exercise tests were not different with salmeterol, salbutamol or placebo, nor did endurance capacity change with any treatment modality. Blood lactate levels, after 15 min exercise, were significantly higher with salbutamol (3.64 (1.83) mM), but not with salmeterol (3.03 (1.64) mM), compared with placebo (2.95 (1.69) mM). These results demonstrate the absence of significant cardiorespiratory or metabolic effects during exercise after a single dose of salmeterol, together with a lack-of ergogenic effect, as measured by maximal or endurance exercise performance, in patients with asthma.
Does childhood obesity influence asthma, or wheeze phenotype at age 6 years?
Authors: Katharine Pike, Hazel Inskip, Sarah Crozier, Keith Godfrey, Graham Roberts, Jane Lucas
Journal: European Respiratory Journal (2013)

Rationale  Obesity is associated with adult asthma, notably non-atopic asthma. Obesity-related systemic inflammation and mechanical effects may explain this association. The relationship between obesity and childhood asthma is unclear.   Methods  3 and 6-year age, height and gender standardised body mass index (BMI) z-scores were calculated for 937 children from the Southampton Women’s Survey. Relative risks per SD BMI were calculated for questionnaire-determined asthma (ever), and wheeze aged 6 years. Wheeze was classed atopic or non-atopic by skin prick testing. Spirometry, bronchial hyperresponsiveness (BHR) and fractional exhaled nitric oxide (FeNO) were assessed at 6 years. Likely confounders were adjusted for.   Results  3-year BMI was associated with asthma (RR 1.2, p=0.03). Neither 3 nor 6-year BMI was associated with atopy or wheeze phenotype. 3-year BMI and non-atopic wheeze at 6 years were positively but non-significantly associated. 3-year BMI was positively associated with FEV 1  (p=0.02) and BHR (p=0.05). 6-year BMI was inversely associated with FEV 1 /FVC (p=0.04). Neither 3 nor 6-year BMI was associated with FeNO.   Conclusions  This study found 3-year BMI to be associated with asthma and BHR. There was evidence for both developmental and current effects of childhood obesity: higher 3-year BMI, possibly as a marker of adequate nutrition, was associated with higher FEV 1 , whilst higher 6-year BMI predisposed to an obstructive pattern of lung function. Lack of association between BMI and FeNO, together with the non-significant association between 3-year BMI and non-atopic wheeze suggests atopy is unaffected by obesity and that the association between obesity and asthma reflects a non-eosinophilic phenotype.
CD21<sup>−/low</sup>Marginal Zone B Cells Highly Express Fc Receptor-like 5 Protein and Are Killed by Anti-Fc Receptor-like 5 Immunotoxins in Hepatitis C Virus-Associated Mixed Cryoglobulinemia Vasculitis
Authors: Benjamin Terrier, Satoshi Nagata, Tomoko Ise, Michelle Rosenzwajg, Ira Pastan, David Klatzmann, David Saadoun, Patrice Cacoub
Journal: Arthritis & Rheumatology (2013)

Hepatitis C virus (HCV) is associated with B cell lymphoproliferative disorders, including mixed cryoglobulinemia (MC) vasculitis and B cell non-Hodgkin's lymphoma. The expansion of clonal and autoreactive rheumatoid factor-bearing CD21(-/low) marginal zone (MZ) B cells was demonstrated in patients with HCV-associated MC vasculitis. Fc receptor-like (FCRL) proteins comprise a family of immunoregulatory proteins preferentially expressed on B lineage cells. The goal of this study was to investigate the expression of FCRL proteins 1-5 on B cells from patients with HCV-associated MC vasculitis.Expression of FCRL proteins 1-5 was assessed by flow cytometry on B cells from 15 HCV-infected patients with type II MC (7 of whom had B cell non-Hodgkin's lymphoma), 20 HCV-infected patients without MC, and 20 healthy donors. To evaluate FCRL-5 as an immunotherapy target in HCV-associated MC vasculitis, 2 anti-FCRL-5 recombinant immunotoxins were produced using anti-FCRL-5 monoclonal antibodies and Pseudomonas exotoxin.Expression of FCRLs 2, 3, and 5 was markedly increased while expression of FCRL-1 was decreased on clonal CD21(-/low) MZ B cells, as compared with other B cell subsets, from HCV-infected patients and healthy donors. However, there was no difference in the pattern of FCRL expression between HCV-MC patients with lymphoma and those without lymphoma. The anti-FCRL-5 immunotoxins showed specific cytotoxicity against FCRL-5-expressing clonal CD21(-/low) MZ B cells isolated from HCV-infected patients as well as FCRL-5-transfected cell lines. No cytotoxicity against T cells or conventional B cells was observed.These findings suggest that FCRL-5-targeting therapies could be a specific treatment for HCV-associated MC vasculitis and other FCRL-5-positive autoimmune B cell disorders.
Abstract 15887: Anemia, Red Blood Cell Transfusion, and Mortality in Patients With Acute Coronary Syndromes: A Meta-Analysis and Systematic Review
Authors: Patrick R Lawler, Kristian B Filion, Michael Garfinkle, Mark J Eisenberg
Journal: Circulation (2011)

Background - Despite the high prevalence of anemia among patients presenting with acute coronary syndromes (ACS), the impact of anemia on their outcomes is incompletely understood. Furthermore, the...
Measurement of Serum Ferritin by Radioimmunoassay: Results in Normal Individuals and Patients With Breast Cancer 2
Authors: Donald M. Marcus, Nira Zinberg
Journal: JNCI Journal of the National Cancer Institute (1975)

Journal Article Measurement of Serum Ferritin by Radioimmunoassay: Results in Normal Individuals and Patients With Breast Cancer Get access Donald M. Marcus, Donald M. Marcus Search for other works by this author on: Oxford Academic PubMed Google Scholar Nira Zinberg Nira Zinberg Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 55, Issue 4, October 1975, Pages 791–795, https://doi.org/10.1093/jnci/55.4.791 Published: 01 October 1975 Article history Received: 01 May 1975 Accepted: 17 June 1975 Published: 01 October 1975
Characterization of myofibroblasts cultured from small volumes of diagnostic bronchoalveolar lavage fluid samples
Authors: Riitta Kaarteenaho, Henna Karvonen, Terttu Harju, Raija Sormunen, Elisa Lappi-Blanco, Meeri Keinänen, Heta Merikallio, Siri Lehtonen
Journal: European Respiratory Journal (2011)

Myofibroblasts are supposed to have a key role in pathogenesis of fibrotic lung diseases. Our aim was to standardize process for culturing cells from small volumes of diagnostic bronchoalveolar lavage (BAL) fluid samples and to characterize the cultured cells. Small volumes of BAL samples were collected from 98 patients that underwent bronchoscopy and BAL for diagnostic purposes. Cells were visualized by electron and immunoelectron microscopy. Proliferation and invasion capacities as well as stem cell properties of the cells were evaluated. Colonies of proliferating fibroblast type cells could be seen in 62% of samples. The success rate varied significantly based on the disease being 92% in idiopathic pulmonary fibrosis (IPF), 80% in non-specific interstitial pneumonia, 89% in collagen vascular disease associated interstitial lung disease, 62% in asbestosis, 53% in sarcoidosis, 100% in allergic alveolitis, 80% in drug reaction, 40% in lung cancer and 25% in normal lung. The success was not dependent on volume or cell amount of the BAL sample. The cultured cells were either fibroblasts or myofibroblasts. Typical features of myofibroblasts were detectable in the cells by electron and immunoelectron microscopy. Some cell samples exhibited differentiation potency into osteoblasts or adipocytes. The invasion capacity varied in different disorders being the highest in IPF-patients. We concluded that myofibroblasts can be cultured from small volumes of diagnostic BAL fluid samples. This method could increase the usability of BAL fluid both in diagnostics of interstitial lung diseases and in scientific research.