tbuckley/cabot-search huggingface dataset:
Drug points: Atrial fibrillation associated with sumatriptan
Authors: D R Morgan, M Trimble, G E McVeigh
Journal: BMJ (2000)

A 34 year old man with a history of migraine presented with palpitations after taking sumatriptan by nasal spray for a severe headache. Examination was unremarkable apart from atrial fibrillation, with a ventricular rate of 130 beats/min. He recalled having had a fast irregular pulse after taking sumatriptan previously, and this was confirmed from his case notes. He reverted to sinus rhythm spontaneously within …
476. Human Mesenchymal Stem Cells Genetically Modified To Express High Levels of Erythropoietin through Transfer of an Artificial Chromosome Engineered Using the ACE System
Authors: Caroline Lonez, Jean-Marie Ruysschaert, Abdelatif Elouahabi
Journal: Molecular Therapy (2004)

Cationic lipids represent a safe alternative to viral vectors for gene therapy applications but their use is still limited by a low in vivo gene transfer efficiency. We report here that cationic lipid-mediated intravenous transfection efficiency can be improved by a single preinjection of free diC14-amidine liposomes or of the steroidal anti-inflammatory drug dexamethasone (Dex). This improvement is dose dependent. Surprisingly, the transfection activity of the complex was enhanced by approximately 24 fold when both diC14-amidine free liposomes and Dex were preinjected, at a doses where individually they have no effect. Synergy between diC14-amidine free liposomes and Dex improved also the intravenous transfection efficiency of DOTAP/DNA lipoplex demonstrating that the method is applicable to other lipoplexes. These finding suggest preinjection of diC14-amidine and dexamethasone as a way to improve the gene transfer efficiency and reduce the toxicity of liposomes.
The health of American Indians and Alaska Natives
Authors: Charles W Grim
Journal: BMJ (2003)

Health influence factors in common with other indigenous populations 

From BMJ USA 2003;May:242 

The health and welfare of the indigenous American Indian and Alaska Native people of the United States have improved significantly since passage of the Snyder Act in 1921, which authorized health services for them, and official establishment of the Indian Health Service (IHS) in 1955 as an agency of the US Department of Health and Human Services. Although the American Indian and Alaska Native populations of the United States number approximately 2.6 million, the provision of federal health services is available only to members of tribes that are federally recognized. Currently there are 562 federally recognized tribes in this country, with a total population of 1.6 million persons who are eligible for IHS services. Of the 50 states, 35 are considered “reservation” states because of the presence of Indian reservations - with 55.7 million acres of tribal land held in trust by the US government for the benefit of tribal governments and their members.1

A significant factor in the improvement of health status for American Indians and Alaska Natives is the increasing involvement …
A multicenter study of recombinant factor VIII (recombinate): safety, efficacy, and inhibitor risk in previously untreated patients with hemophilia A. The Recombinate Study Group.
Authors: Bray Gl, Gomperts Ed, Courter S, Gruppo R, Gordon Em, Manco-Johnson M, Shapiro A, Scheibel E, White G rd, Lee M
Journal: Blood (1994)
Synthesis of the literature on the effectiveness of regional anesthesia for cataract surgery11This article is based on research conducted by the Johns Hopkins University under contract to the Agency for Healthcare Research and Quality, formerly the Agency for Health Care Policy and Research (contract no.: 290-97-0006). The authors of this article are responsible for its contents, including any clinical or treatment recommendations. No statement in this article should be construed as an official…
Authors: David S Friedman, Eric B Bass, Lisa H Lubomski, Lee A Fleisher, John H Kempen, Jeffrey Magaziner, Michael Sprintz, Karen Robinson, Oliver D Schein
Journal: Ophthalmology (2001)
Abstract 1575: ARF regulates the stability of p16 protein via REGγ-dependent proteasome degradation
Authors: Takashi Kobayashi, Osamu Ogawa, Cory Abate-Shen
Journal: Cancer Research (2014)

Abstract The cell cycle regulatory gene INK4A-ARF (CDKN2A) has two alternative transcripts that produce entirely different proteins, namely p14ARF and p16, which have complementary functions as regulators of p53 and pRB tumor suppressor pathways, respectively. The unusual organization of INK4A-ARF has long led to speculation of a need for coordinated regulation of p14ARF and p16. We now show that p14ARF (ARF) regulates the stability of p16 protein in human cancer cell lines, as well as in mouse embryonic fibroblasts (MEFs). In particular, ARF promotes rapid degradation of p16 protein, which is mediated by the proteasome and, more specifically, by interaction of ARF with one of its subunits, REGγ. Furthermore, this ARF-dependent destabilization of p16 can be abrogated by knock-down of REGγ or by pharmacological blockade of its nuclear export. Thus our findings have uncovered a novel crosstalk of two key tumor suppressors mediated by a REGγ-dependent mechanism. Citation Format: Takashi Kobayashi, Osamu Ogawa, Cory Abate-Shen. ARF regulates the stability of p16 protein via REGγ-dependent proteasome degradation. [abstract]. In: Proceedings of the 105th Annual Meeting of the American Association for Cancer Research; 2014 Apr 5-9; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2014;74(19 Suppl):Abstract nr 1575. doi:10.1158/1538-7445.AM2014-1575
Spotlight on measles 2010: An epidemiological overview of measles outbreaks in Poland in relation to the measles elimination goal
Authors: J Rogalska, S Santibanez, A Mankertz, A Makowka, L Szenborn, P Stefanoff
Journal: Eurosurveillance (2010)

The objective of this study was to describe transmission chains of measles observed in Poland during 2008-2009. A decade ago, the incidence of measles in Poland declined and approached one case per million inhabitants one of the World Health Organization's criteria for measles elimination. Following a period of very few reported measles cases (2003 to 2005), an increase in incidence was observed in 2006. Since then, the incidence has constantly exceeded one case per million inhabitants. Of 214 measles cases reported in 2008 and 2009 in Poland, 164 (77%) were linked to 19 distinct outbreaks, with 79% of cases belonging to the Roma ethnic group. Outbreaks in the non-Roma Polish population had different dynamics compared to those in the Roma population. On average, measles outbreaks in Roma communities involved 10 individuals, seven of whom were unvaccinated, while outbreaks in the non-Roma Polish population involved five individuals, half of whom were incompletely vaccinated. The majority of outbreaks in Roma communities were related to importation of virus from the United Kingdom. In six outbreaks, the epidemiologic investigation was confirmed by identification of genotype D4 closely related to measles viruses detected in the United Kingdom and Germany. Our data indicate that Poland is approaching measles elimination, but measles virus circulation is still sustained in a vulnerable population. More efforts are needed to integrate the Roma ethnic group into the Polish healthcare system and innovative measures to reach vulnerable groups should be explored.
The Content of Eosinophil Cationic Protein in Eosinophil Leucocytes
Authors: Ronald Dahl, Per Venge, Inge Olsson
Journal: Allergy (1978)

Eosinophil cationic protein consitutes a major pan of eosinophil Leucocyte granule protein. Low serum concentrations have previously been found in patients with bronchial asthma. As this might reflect a low intracellular content, eosinophils were isolated from normal controls and patients with bronchial asthma. Eosinophil cationic protein was estimated after extraction of the cells and a similar content was found in cells from both groups.
Posture and Lumbar Puncture Headache: A Controlled Trial in 50 Patients
Authors: Clive E Handler, G D Perkin, F R Smith, F Clifford Rose
Journal: Journal of the Royal Society of Medicine (1982)

A prospective single blind trial in 50 patients was performed to investigate the effect of posture on post lumbar puncture headache (LPH). A difference between the frequency of headache at five hours between the two groups (prone for four hours, versus 30° head down tilt for 30 minutes followed by supine posture for 3 1/2 hours) did not reach significance. These findings do not support the suggestion that a prone posture, by possibly reducing cerebrospinal fluid (CSF) leakage, significantly reduces the frequency of this common clinical problem. The value of bed rest after lumbar puncture remains equivocal. Other methods used for reducing LPH are reviewed.
Endoscopic Fluorescence Detection of Intraepithelial Neoplasia in Barrett's Esophagus after Oral Administration of Aminolevulinic Acid
Authors: T.  Stepinac, C.  Felley, P. Jornod, N.  Lange, T.  Gabrecht, C.  Fontolliet, P.  Grosjean, G.  van Melle, H.  van den Bergh, P.  Monnier, G.  Wagnières, G.  Dorta
Journal: Endoscopy (2003)

Background and Study Aims: Barrett's esophagus is strongly associated with adenocarcinoma. Early malignant transformation of the Barrett's mucosa is often not visible endoscopically and may remain undetected until the invasive adenocarcinoma stage. Endoscopic surveillance is currently carried out on random four-quadrant biopsies at 1-2 cm intervals. Endoscopic fluorescence detection of protoporphyrin IX induced by 5-aminolevulinic acid can identify premalignant lesions. This study evaluates endoscopic fluorescence detection in patients having Barrett's esophagus and compares the results to those of standard endoscopy with random four-quadrant biopsies.Patients and Methods: The study included 30 examinations in 28 patients (22 men, 6 women; age range 37-78 years, mean age 60 years,), with five patients having known intraepithelial neoplasia. A dose of 20 mg/kg of 5-aminolevulinic acid was given orally 5 hours before examination. Random four-quadrant biopsies were performed 4-6 weeks before endoscopic fluorescence detection.Results: Of the biopsies taken during the endoscopic fluorescence detection procedure, 28 % (23/81) were true positives. More than one-third of the false-positive results were due to inflammation. None of the 97 control biopsies taken on nonfluorescing areas during endoscopic fluorescence detection were dysplastic. Endoscopic fluorescence detection showed low-grade intraepithelial neoplasia in five patients which was not diagnosed with random four-quadrant biopsies, while random four-quadrant biopsies alone showed three low-grade intraepithelial neoplasias that were invisible during endoscopic fluorescence detection. All high-grade intraepithelial neoplasias or adenocarcinomas (2/2) were detected with both methods.Conclusions: Fluorescence detection achieved a similar performance when compared with four-quadrant random biopsy, but resulted in fewer biopsies (81 for endoscopic fluorescence detection vs 531 for random four-quadrant biopsies).
Abstract 3822: Correlation between worse prognosis and lower expression of the <i>TPPP</i> gene in patients with hepatocellular carcinoma, detected by multiarray analysis
Authors: Yoshikuni Inokawa, Shuji Nomoto, Mitsuhiro Hishida, Nao Takano, Mitsuro Kanda, Michitaka Fujiwara, Masahiko Koike, Hiroyuki Sugimoto, Tsutomu Fujii, Goro Nakayama, Suguru Yamada, Chie Tanaka, Daisuke Kobayashi, Naoki Iwata, Yasuhiro Kodera
Journal: Cancer Research (2014)

Abstract Background. Hepatocellular carcinoma (HCC) patients who undergo liver resection often suffer multicentric occurrence after surgery. Therefore, understanding carcinogenesis in background liver is important. Methods. Control liver samples (super normal [SN]), were taken from 11 cases of metastatic liver cancer. We selected corresponding normal tissue from typical cases of HCC with chronic hepatitis C (corresponding normal [CN]) for comparison. Expression profiling and methylation arrays were performed to compare SN and CN. Array data showed that the tubulin polymerization promoting protein (TPPP) gene showed differences in both array analyses. The relationship between clinicopathological factors of 179 HCC patients and TPPP expression was investigated. Results. The expression array showed that the TPPP gene was decreased by 2.236-fold (log2 ratio) in CN compared with SN. The methylation array showed a higher value of methylation for CN (0.730) than SN (0.384). We studied TPPP gene expression by real-time reverse transcription PCR. When compared expression level of TPPP (TPPP value ×103/GAPDH), among SN (n=11), normal liver tissue of HCC patients (n=179), and tumor tissue of HCC (n=179), there were significant differences (median: 116, 4.60, and 2.63, respectively). The group with lower TPPP expression in tumors compared with normal tissue showed a worse prognosis of overall survival than that in the increased expression group (P=0.0317). Strongly reduced TPPP expression in tumor tissue compared with normal tissue (ratio &amp;lt;0.3, n=57) was detected as an independent prognostic factor by multivariate analysis (P=0.0310). Conclusions. Expression of the TPPP gene in tumor and non-cancerous liver tissue in HCC patients is significantly lower compared with SN. HCC patients with this low TPPP expression show a poor prognosis. This indicates that this gene is a new candidate of tumor suppressor genes in HCC. Low TPPP expression in liver tissue might be a predictor of HCC. Citation Format: Yoshikuni Inokawa, Shuji Nomoto, Mitsuhiro Hishida, Nao Takano, Mitsuro Kanda, Michitaka Fujiwara, Masahiko Koike, Hiroyuki Sugimoto, Tsutomu Fujii, Goro Nakayama, Suguru Yamada, Chie Tanaka, Daisuke Kobayashi, Naoki Iwata, Yasuhiro Kodera. Correlation between worse prognosis and lower expression of the TPPP gene in patients with hepatocellular carcinoma, detected by multiarray analysis. [abstract]. In: Proceedings of the 105th Annual Meeting of the American Association for Cancer Research; 2014 Apr 5-9; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2014;74(19 Suppl):Abstract nr 3822. doi:10.1158/1538-7445.AM2014-3822
HEMOLYTIC ANEMIA COMPLICATING PRIMARY ATYPICAL PNEUMONIA WITH COLD ISOHEMAGGLUTININS
Authors: B BATTAGLIA
Journal: Annals of Internal Medicine (1947)

Case Reports1 September 1947HEMOLYTIC ANEMIA COMPLICATING PRIMARY ATYPICAL PNEUMONIA WITH COLD ISOHEMAGGLUTININSBIAGIO BATTAGLIABIAGIO BATTAGLIASearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-27-3-469 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptHemolytic anemia of varying severity, associated with cold isohemagglutinins, in primary atypical pneumonia has been previously reported.1, 2, 3 In a series of 200 cases, hemolytic anemia was noted in 11.2 It occurred at a time when the maximal titer of cold agglutinins is most often encountered, between the middle of the second and the middle of the fourth week. The presence of cold agglutinins in high titer does not necessarily result in such hemolytic phenomena.3 In some of the previously reported cases the administration of a sulfonamide compound has been considered a contributory cause of the hemolytic crisis.1The...Bibliography1. DAMESHEK W: Cold hemagglutinins in acute hemolytic reactions, Jr. Am. Med. Assoc., 1943, cxxiii, 77-80. CrossrefGoogle Scholar2. FINLAND M: Cold isohemagglutinins in primary atypical pneumonia, Jr. Clin. Invest., 1945, xxiv, 458-473. CrossrefGoogle Scholar3. YOUNG LE: Clinical significance of cold hemagglutinins, Am. Jr. Med. Sci., 1946, ccxi, 23-39. CrossrefGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Brooklyn, N. Y.*A hydrolysate of lactalbumin, supplied us by Frederick Stearns & Co.†Received for publication March 6, 1947. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byThe Lab: Serological Diagnosis of Acquired Hemolytic AnemiaSerologie und Klinik der autoimmunhämolytischen ErkrankungenTYPE-SPECIFIC COLD AUTO-ANTIBODIES AS A CAUSE OF ACQUIRED HEMOLYTIC ANEMIA AND HEMOLYTIC TRANSFUSION REACTIONS: BIOLOGIC TEST WITH BOVINE RED CELLS*A. S. WIENER, F.A.C.P., L. J. UNGER, L. COHEN, J. FELDMANThe Syndrome of High-Titre Cold Hemagglutination. 1 September 1947Volume 27, Issue 3Page: 469-471KeywordsAgglutininsHemolytic anemiaPneumoniaSulfonamide ePublished: 1 December 2008 Issue Published: 1 September 1947 PDF downloadLoading ...
The Relationship Between Metabolic Risk Factors and Incident Cardiovascular Disease in Europeans, South Asians, and African Caribbeans
Authors: Therese Tillin, Alun D. Hughes, Jamil Mayet, Peter Whincup, Naveed Sattar, Nita G. Forouhi, Paul M. McKeigue, Nish Chaturvedi
Journal: Journal of the American College of Cardiology (2013)

This study sought to determine whether ethnic differences in diabetes, dyslipidemia, and ectopic fat deposition account for ethnic differences in incident cardiovascular disease.Coronary heart disease risks are elevated in South Asians and are lower in African Caribbeans compared with Europeans. These ethnic differences map to lipid patterns and ectopic fat deposition.Cardiovascular risk factors were assessed in 2,049 Europeans, 1,517 South Asians, and 630 African Caribbeans from 1988 through 1991 (mean age: 52.4 ± 6.9 years). Fatal and nonfatal events were captured over a median 20.5-year follow-up. Subhazard ratios (SHR) were calculated using competing risks regression.Baseline diabetes prevalence was more than 3 times greater in South Asians and African Caribbeans than in Europeans. South Asians were more and African Caribbeans were less centrally obese and dyslipidemic than Europeans. Compared with Europeans, coronary heart disease incidence was greater in South Asians and less in African Caribbeans. The age- and sex-adjusted South Asian versus European SHR was 1.70 (95% confidence interval [CI]: 1.52 to 1.91, p < 0.001) and remained significant (1.45, 95% CI: 1.28 to 1.64, p < 0.001) when adjusted for waist-to-hip ratio. The African Caribbean versus European age- and sex-adjusted SHR of 0.64 (95% CI: 0.52 to 0.79, p < 0.001) remained significant when adjusted for high-density lipoprotein and low-density lipoprotein cholesterol (0.74, 95% CI: 0.60 to 0.92, p = 0.008). Compared with Europeans, South Asians and African Caribbeans experienced more strokes (age- and sex-adjusted SHR: 1.45 [95% CI: 1.17 to 1.80, p = 0.001] and 1.50 [95% CI: 1.13 to 2.00, p = 0.005], respectively), and this differential was more marked in those with diabetes (age-adjusted SHR: 1.97 [95% CI: 1.16 to 3.35, p = 0.038 for interaction] and 2.21 [95% CI: 1.14 to 4.30, p = 0.019 for interaction]).Ethnic differences in measured metabolic risk factors did not explain differences in coronary heart disease incidence. The apparently greater association between diabetes and stroke risk in South Asians and African Caribbeans compared with Europeans merits further study.
Determinative Bacteriology Laboratory Manual
Authors: Thomas Henry Lord
Journal: JAMA (1952)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Contrasts and dissociations suggest qualitative differences between conscious and unconscious processes
Authors: Gezinus Wolters, R. Hans Phaf
Journal: Behavioral and Brain Sciences (2002)

The authors reject a computationally powerful unconscious. Instead, they suggest that simple unconscious processes give rise to complex conscious representations. We discuss evidence showing contrastive effects of conscious and unconscious processes, suggesting a distinction between these types of processes. In our view, conscious processes often serve to correct or control negative consequences of relatively simple unconscious processes.
Pioneer Accountable Care Organizations
Authors: Lawrence P. Casalino
Journal: JAMA (2015)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Biological and chemical terrorism: strategic plan for preparedness and response.
Authors: S. L. Groseclose, E. K. Gray, E. W. Gunter, A. B. Johnson, A. L. Wilson, D. A. Ashford, R. B. Craven, R. P. Gaynes, S. A. Morse, C. J. Peters, R. A. Spiegel, D. L. Swerdlow, S. D. Deitchman, P. K. Halverson, J. Hughart, P. Quinlisk
Journal: MMWR Morbidity and Mortality Weekly Report (2000)
Proposal Published on Dissemination of Information on Unapproved Uses
Authors: Stuart L. Nightingale
Journal: JAMA (1998)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal