tbuckley/cabot-search huggingface dataset:
Abstract 17396: Iron Deficiency as the Most Ominous Substrate for Anemia in Patients Undergoing Coronary Artery Bypass Surgery
Authors: Susanne Weissert, Julia Flint, Suneil Aggarwal, Alistair Connell, Francesco Papalia, Girish Babu, Hua Zen Ling, Nay Aung, Toby Richards, Darlington Okonko
Journal: Circulation (2011)

Background: Whilst pre-operative anemia escalates morbidity and mortality after coronary artery bypass grafting (CABG), it is unclear whether its different etiologies confer different magnitudes of risk. Because iron is quantitatively the most important biocatalyst in human physiology, we hypothesized that iron deficiency (ID) anemia (IDA) might confer the greatest hazard. Additionally, we supposed that ID even in the absence of anemia might be detrimental. Methods: We analysed hospital outcomes in 1910 CABG patients (mean [±SD] age 67±10 years, EuroSCORE 4±3%, 79% male, 36% CCS class&gt;2). The combination of a red cell distribution width≥15% and a mean cell volume ≤80fL was utilised to identify ID as it has a ≥90% sensitivity and specificity for this diagnosis. A hemoglobin &lt;13g/dL in males and &lt;12g/dl in females defined anemia. Results: On admission, 70%, 27%, and 3% of patients had no anemia, non-iron deficiency anemia (NIDA), and IDA, respectively. Patients with IDA were more likely to be female (38% vs 21%), diabetic (53% vs 25%), with poorer ejection fractions (51% vs 33% with EF&lt;50%), more congestive symptoms (15% vs 5%), and higher CCS class (2.5±1.6 vs 2.1±1.2), EuroSCOREs (5±3 vs 4±3) and post-op renal (15% vs 8%) and neurological (16% vs 5%) complications (all P&lt;0.05). Over a median (±IQR) hospital stay of 10±12 days, 46 (2.4%) patients died. IDA predicted inpatient mortality (HR 3.9, CI: 1.6-9.3, P=0.002) independently of all covariates including the EuroSCORE, and conferred a greater risk than NIDA (Fig A ). Interestingly, ID per se also predicted an escalated risk of death (unadjusted HR 3.3, CI:1.4-7.8, P=0.007, Fig B ) and did so independently of the presence of anemia (ID adjusted HR 2.6, CI:1.1-6.5, P=0.03). Conclusions: Pre-operative iron deficiency is the most ominous cause of anemia in CABG patients and confers adversity even in the absence of anemia. Optimizing iron status in anemic and non-anemic subjects might improve outcomes.
Duration of Ischemia Is a Major Determinant of Transmurality and Severe Microvascular Obstruction After Primary Angioplasty
Authors: Giuseppe Tarantini, Luisa Cacciavillani, Francesco Corbetti, Angelo Ramondo, Martina Perazzolo Marra, Enrico Bacchiega, Massimo Napodano, Claudio Bilato, Renato Razzolini, Sabino Iliceto
Journal: Journal of the American College of Cardiology (2005)
Abstract 20007: Effects of Eicosapentaenoic Acid, Docosahexaenoic Acid, and Olive Oil on Cardiovascular Disease Risk Factors
Authors: Ernst J Schaefer, Ivor B Asztalos, Joi A Gleason, Bela F Asztalos, Katalin Horvath, Michael L Dansinger, Peter J Gillies
Journal: Circulation (2010)

The effects of eicosapentaenoic acid (EPA) 600 and 1800 mg/day and docosahexaenoic acid (DHA) 600 mg/day versus olive oil placebo on cardiovascular disease (CVD) risk factors were examined over a 6...
Abstract 4047: High Volume Transplant Centers Achieve Better Post-transplant Survival In Low And High-risk Recipients
Authors: Mark Russo, Kimberly N Hong, Alexander Iribarne, Basel Ramlawi, Ryan Davies, Hiroo Takayama, Michael Argenziano, Annetine Gelijns, Yoshifumi Naka
Journal: Circulation (2009)

Purpose. Previous studies have demonstrated a relationship between increasing center volume and outcomes in cardiac transplant. The purpose of this study was to examine the relationship between cen...
Abstract 1964: Bone Morphogenetic Protein Antagonist “Protein Related to Dan and Cerberus” Promotes Differentiation of Embryonic Stem Cells to Atrial Cardiomyocytes
Authors: Jingbo Yan, Jianyong Hu, Iris I Mueller, William H Heaton, Wan-Der Wang, Igor Dzhura, Franz Baudenbacher, Ela W Knapik, Antonis K Hatzopoulos
Journal: Circulation (2008)

The molecular factors that regulate cardiac differentiation have been extensively studied, yet, relatively little is known about how cardiomyocytes acquire atrial versus ventricular characteristics. Embryonic stem (ES) cells, which have the potential to differentiate to a wide array of distinct cell types, including most types of cardiovascular cells, offer a pertinent in vitro model to work out the molecular mechanisms of atrial specification and differentiation. We discovered that the secreted antagonist of BMP signaling, Protein Related to Dan and Cerberus (PRDC, also called Gremlin2) leads to a surge in cardiomyocytic differentiation when applied to mouse ES-derived cardiac progenitor cells. This property is unique to PRDC among tested BMP antagonists. Lineage expansion is restricted to cardiomyocytes, with the differentiation of endodermal, blood, endothelial and neuronal cells being unaffected. Using molecular and electrophysiological analyses, we show that PRDC-induced cardiomyocytes acquire atrial characteristics. Consistent with the in vitro results, we found that injection of PRDC mRNA into the developing zebrafish embryo leads to supernumerary contracting areas. The ectopic cardiomyocytes express atrial-, but not ventricular- specific cardiac genes. We determined that PRDC treatment induces the expression of COUP-TFII, a known transcriptional regulator of atrial differentiation, but suppresses Notch signaling. Inhibition of Notch is sufficient to induce atrial-specific genes; however, blocking Notch does not expand the cardiogenic fields. Taken together, our data suggest that antagonism of BMP and Notch signaling by PRDC is a critical early step in the specification, expansion and differentiation of atrial progenitor cells. This information might be relevant for treating atrial degeneration, as well as for understanding the etiology of atrial fibrillation.
Abstract 13635: CETP Inhibitor (Torcetrapib) Induces LDL Particle Polydispersity Like that Observed in CETP Deficient Homozygote Subjects
Authors: Elizabeth T Leary, Caicai Wu, Tonya Aggoune, Charles Shear, Timothy H Carlson
Journal: Circulation (2011)

Background: LDL subclass distribution may be correlated with CVD risk. An advantage of gradient gel electrophoresis (GGE) is that it gives a visual image of the subfractions. This report is the fir...
Abstract 10994: Use of Aspiration Thrombectomy and Practice Patterns During Primary PCI for STEMI – Results of an International Survey
Authors: Juan J Russo, Vladimír Džavík, John A Cairns, Petr Widimsky, Sunil V Rao, Markku Eskola, Kari O Niemelä, Olivier F Bertrand, Pawel Maciejewski, Madhu K Natarajan, Asim Cheema, Anthony Fung, Sanjit S Jolly
Journal: Circulation (2010)

Background:  Small randomized trials and meta-analyses of aspiration thrombectomy (AT) for STEMI demonstrate improved angiographic outcomes and suggest a possible reduction in mortality but an increase in stroke. We conducted an international survey of the extent and patterns of use of AT and assessed the feasibility of performing a definitive, large randomized trial.   Methods:  A 27-item survey was distributed to 1616 interventional cardiologists (IC) internationally through various national organizations and investigator networks.   Results:  A total of 425 surveys were completed (response rate 26%). AT is used routinely by 33% and selectively by 62% of IC during primary PCI. Overall, respondents use AT in 51% (standard deviation (SD) 31%) of their cases of primary PCI for STEMI. Common utilization criteria include: large thrombus (84%), TIMI 0 or 1 flow (55%), and proximal coronary artery occlusion (33%). Regarding technique, i) 79% turn on suction prior to advancing the catheter through the target lesion and ii) 81% remove the catheter from the target vessel under continuous suction. One-fifth (20%) of IC report having experienced at least one serious complication from aspiration thrombectomy, including: thrombus brought back from target vessel into left main (5%), left main dissection (   Conclusions:  This is the first international survey of AT and it shows that it is used routinely by less than one-third of IC. In “real world” practice, complications related to AT are not infrequent. The data suggests that a definitive trial is needed and that there is sufficient equipoise and interest among IC such that a trial is feasible in the current era.
Abstract 5093: Atorvastatin Reduces Macrophage Accumulation in the Atherosclerotic Plaque: A Comparison versus Non-statin Based Regimen in Patients Undergoing Carotid Endarterectomy
Authors: Massimo Puato, Elisabetta Faggin, Marcello Rattazzi, Francesco Cipollone, Alberto Zambon, Franco Grego, Andrea Mezzetti, Paolo Pauletto
Journal: Circulation (2009)

Several studies suggested that statins may exert anti-atherosclerotic effects beyond cholesterol lowering. No definite data on humans are available confirming this hypothesis. To compare the effect of high dose vs low dose of atorvastatin vs non-statin based treatment (cholestyramine plus sistosterol) on carotid plaque composition, we studied 60 hypercholesterolemic patients (total cholesterol, TC, 225–295 mg/dl) eligible for carotid endarterectomy. Three months prior surgery patients were randomized into 3 groups (n=20) receiving atorvastatin 10 mg/day (AT-10), or atorvastatin 80 mg/day (AT-80), or cholestyramine 8 g/day plus sitosterol 2.5 g/day (C-S). Blood samples were collected to assess lipid profile and inflammatory markers levels. Analysis of carotid plaque cell composition and lipid content was performed on endarterectomy specimens. The AT-80 group showed the highest reduction in TC and LDL cholesterol (LDL-C) levels. A comparable TC and LDL-C level was achieved in the AT-10 and C-S groups. The three regimens did not significantly influence the levels of inflammatory markers (including hs-PCR). A lower content in macrophages was observed in the AT-10 group plaques compared to the C-S group. The macrophage content was further on reduced in the AT-80 group plaques. No difference in lymphocyte number was observed among treatments while the content of smooth muscle cells was higher in the AT- 80 group. The plaque lipid content was similar in the 3 groups. In conclusion, dspite a comparable reduction in cholesterol levels, atorvastatin treatment was superior to a non-statin based regimen in blunting macrophage accumulation inside carotid atherosclerotic plaque.
Abstract 16242: Atorvastatin Preserves the Integrity of Adherens Junctions in Endothelial Cells
Authors: Mehran Haidari, Wei Zhang, Zhenping Chen, Richard Dixon
Journal: Circulation (2011)

Endothelial barrier function depends on the integrity of intercellular adherens junctions formed by the complex between VE-cadherin (VE-cad) and catenins. VE-cad tyrosine phosphorylation has been i...
Concurrent Expression Of MYC/BCL2 Protein In Newly Diagnosed DLBCL Is Not Associated With An Inferior Survival Following EPOCH-R Therapy
Authors: Kieron Dunleavy, Stefania Pittaluga, Margaret Shovlin, Svetlana Pack, Seth M. Steinberg, Catherine E. Lai, Cliona Grant, Eric D. Hsi, Louis M. Staudt, Elaine S. Jaffe, Wyndham H Wilson
Journal: Blood (2013)
Abstract 17110: Prognostic Value of the Residual SYNTAX Score to Quantify Untreated Coronary Artery Disease After Coronary Artery Bypass Grafting
Authors: Giovanni Melina, Emiliano Angeloni, Simone Refice, Furio Colivicchi, Francesco Monti, Pietro Spitaleri, Fabio Capuano, Cosimo Comito, Antonino Roscitano, Roberto Bianchini, Roberto Serdoz, Riccardo Sinatra
Journal: Circulation (2013)

Background: It has been previously shown that incomplete revascularization (IR) after CABG is associated with a worse prognosis compared with complete revascularization (CR). However, formal quanti...
Abstract 5865: High-density Lipoproteins (HDL) Are Present In Stenotic Aortic Valves And May Protect Them Against Calcification
Authors: Jaakko I Lommi, Petri T Kovanen, Miriam Lee-Rueckert, Markku Kupari, Satu Helske
Journal: Circulation (2008)

Purpose: The pathogenesis of aortic valve stenosis (AS) is characterized by accumulation of low-density lipoprotein (LDL) cholesterol and inflammatory cells in aortic valves, as well as by marked calcification and bone formation in the affected leaflets. Hitherto, the factors which inhibit aortic valve calcification have remained obscure. We aimed to determine, whether HDL cholesterol particles enter aortic valve leaflets and whether HDL could protect the valves from cholesterol accumulation and calcification. Methods: Stenotic aortic valves were obtained from 10 AS patients undergoing valve replacement surgery. Non-stenotic control valves (n=10) were collected from cardiac transplantations. The amount and localization of HDL/apolipoprotein (apo) A-I, apoB, apoE, and osteoprotegerin (OPG) were analyzed by immunohistochemistry and computer-assisted morphometry. Myofibroblasts were isolated from aortic valves and their secretion of calcific mediators in response to HDL-stimulation was studied by real-time PCR and ELISA. Results: Accumulation of HDL/apoA-I was detected in both control and stenotic aortic valves. HDL was detected particularly around calcific deposits in the stenotic valves, in which it was colocalized with apoB and apoE, as well as with OPG. Stimulation of cultured aortic valve myofibroblasts with HDL or apoA-I significantly increased secretion of OPG by these cells (p&gt;0.001), whereas the secretion of RANKL, which counteracts the effects of OPG, remained unchanged. Conclusions: HDL is present locally in human stenotic aortic valves and induces secretion of OPG in valvular cells in vitro. Since OPG is known to inhibit aortic valve calcification, this mechanism may provide HDL a protective role in AS.
Fatal acute melioidosis in a tourist returning from Martinique Island, November 2010
Authors: L Gétaz, M Abbas, L Loutan, J Schrenzel, A Iten, F Simon, A Decosterd, R Studer, P Sudre, Y Michel, P Merlani, S Emonet
Journal: Eurosurveillance (2011)

We report the fatal case of acute melioidosis in a patient returning from Martinique with fever in November 2010. Gram-negative rods were isolated from a blood culture and Burkholderia pseudomallei identified within 24 hours after first medical contact. The patient died two days after admission to hospital despite intravenous therapy with high doses of imipenem/cilastatin and intensive care. Clinicians seeing travellers returning from the subtropics or tropics with severe pneumonia or septicaemia should consider the possibility of acute melioidosis.
Abstract 16497: Prediction of Left Atrial Appendage Thrombus by Spaced in Comparison to Chads2And Cha2Ds2-vasc. Validation Study
Authors: Kevin P Cohoon, Naser Ammash, Matylda Mazur, Alfonso Tafur, Ewa Konik, Diane E Grill, Joshua P Slusser, Robert D McBane, Waldemar E Wysokinski
Journal: Circulation (2012)

BACKGROUND.SPACED (Stroke, Permanent AF, Atrial Fibrillation duration, CHF, presence of sEc, and Diabetes mellitus) is a novel risk assessment tool to determine the thromboembolic propensity of non...
Clinical implication of ERCC1 overexpression in advanced biliary tract adenocarcinoma patients treated with platinum-based palliative chemotherapy
Authors: I. Hwang, K. Chi, J. Do, G. Lee, J. Kang, S. Oh, H. Kwon, H. Park, S. Lee, S. Lee, J. Jang
Journal: Journal of Clinical Oncology (2009)

e22018 Background: Several clinical studies have shown that Excision repair cross-complementation group1 (ERCC1) overexpression is associated with resistance to platinum-based chemotherapy and poor prognoses in several tumors. However these studies have never been tried for biliary tract cancer. The aim of this study was to evaluate the association between ERCC1 expression and treatment outcomes in advanced biliary tract adenocarcinoma patients treated with platinum-based palliative chemotherapy. Methods: We analyzed 45 patients with histologically confirmed adenocarcinoma of biliary tract at 5 institutions between January 2002 and March 2008. ERCC1 expression was assessed by immunohistochemistry from biopsy specimens. Results: ERCC1 expression was positive in 17 of 45 specimens (37.8%). 26 (57.8%) of 45 patients showed clinical benefits(including complete response, partial response and stable disease). Among 26 patients who obtained clinical benefits, seven (27%) were positive for ERCC1 expression and ninety (73%) were negative (p=0.079). With a median follow-up of 6.6 months (range, 0.9–39.4 months), median Progression free survival (PFS) and Overall survival (OS) were 4.4 months (95% CI, 3.2–5.6 months) and 8.5 months (95% CI, 6.1–10.9 months), respectively, for the total study population. On univariate analysis, PFS was 2.3 months for patients with ERCC1 positive tumor and 5.3 months for those with ERCC1 negative tumor (P = 0.053). However OS was significantly longer in the ERCC1-negative group than in the ERCC1-positive group (10.0 vs 4.4 months, respectively; P = 0.001). Other factors affecting the prolongation of OS were objective response rate (P = 0.016) and clinical benefits (P = 0.001). A Cox proportional hazard model showed that negative ERCC1 expression (hazard ratio 0.405, 95% CI, 0.200–0.820; P = 0.012) and clinical benefit (hazard ratio 0.183, 95% CI 0.080–0.420; P = 0.001) were significant independent prognostic factors for the prolongation of survival. Conclusions: These results suggest that advanced biliary tract adenocarcinoma patients with ERCC1-negative tumors show a survival benefit from palliative chemotherapy with a platinum- containing regimen. No significant financial relationships to disclose.
Chorioretinal Toxoplasmosis
Authors: Zouheir Hafidi, Rajae Daoudi
Journal: New England Journal of Medicine (2014)

A 30-year-old man was found on funduscopic examination to have pigmented and sharply demarcated choroidal lesions involving the macular region. The lesions measured 5 mm in the right eye and less than 1 mm in the left eye.
Effects of novel retinoid X receptor-selective ligands on myeloid leukemia differentiation and proliferation in vitro
Authors: M Kizaki, MI Dawson, R Heyman, E Elster, R Morosetti, S Pakkala, DL Chen, H Ueno, W Chao, M Morikawa, Y Ikeda, D Heber, M Pfahl, HP Koeffler
Journal: Blood (1996)
Meeting the demand for donor organs in the US
Authors: R. M Davis
Journal: BMJ (1999)

Personal view p 1445

Walter Payton, the most accomplished running back in the history of American football, died on 1 November at the age of 45. In February he announced that he had primary sclerosing cholangitis. A liver transplant, it was said, was all that could save him. In contacts with the media and on his personal website (http://www.payton34.com/), Payton tried to raise awareness of the need for organ donation. Only after his death did his doctors reveal they had later diagnosed bile duct cancer, which made him ineligible for a transplant. Yet Payton's plight served as a vivid reminder of our failure to supply donor organs to those in need. More than 66 500 patients are waiting for a transplant in the United States,1 and about 4000 Americans will die each year while waiting for organs2—until bold policies are adopted to increase their supply.

The most contentious policy debate surrounding organ transplantation in the US is the way in which scarce organs are distributed. Organ allocation is overseen by the Organ Procurement and Transplantation Network, a private sector system created by the US Congress in 1984. Currently matching organs are made available first to all listed patients in a local organ procurement area, then to patients in the same region (one of 11), and then nationally. Thus …
NF-κB mediated ERK inhibition in radiation-induced radioresistance
Authors: Kazi M. Ahmed, Ming Fan, Chang-Deng Hu, William C. Dewey, Jian-Jian Li
Journal: Cancer Research (2006)

4419   Transcription factors NF-κB and ERK are co-activated in acute response to many stress conditions. Their relationship in signaling the resistance of heterogeneous tumor cells to therapeutic radiation remains to be elucidated. The present study presents the evidence indicating an opposite regulation of NF-κB and ERK pathways in radioresistant breast cancer population (MCF+FIR) derived from fractionated doses of radiation. MCF+FIR cells displayed a heterogenic but temporary advantage of clonogenic survival with an increased NF-κB transcriptional activity and p65 and p50 (NF-κB subunits) expression. Unlike in single dose response, the level of phosphorylated ERK (pERK) was remarkably inhibited in all MCF+FIR cell lines with enhanced NF-κB activity. Phosphorylated MEK (pMEK) that activate ERK was inhibited in MCF+FIR cells but demonstrated a substantial level in MCF-7 cells. Both pMEK and pERK were inhibited with enhanced radioresistance by further irradiation with fractionated doses to MCF+FIR and control MCF-7 cells. Thus, MEK/ERK pathway is significantly down-regulated in radiation derived radioresistant cells. NF-κB subunit p65 interacts with MEK in MCF+FIR cells, suggesting an inhibitory role in MEK/ERK pathway via NF-κB. To identify the elements of up-stream of NF-κB, we observed an  in vivo  association of ATM and NF-κB in MCF+FIR cells but not in wild-type MCF-7 cells, indicating that ATM is involved in NF-kB activation. Direct protein interaction between p65 and ERK1 or ERK2 was further visualized in living cells by bimolecular fluorescence complementation using fusion proteins. p65/ERK interaction and nuclear translocation was significantly decreased in MCF+FIR cells and pMEK/pERK inhibitor PD98059 reduced p65/ERK interaction. In summary, these results demonstrate a novel communication between NF-κB and pMEK/pERK pathway in long-term radiation derived radioresistant populations.
MYC Analysis by Fluorescent In Situ Hybridization and Immunohistochemistry in Primary Adrenal Angiosarcoma (PAA): a Series of Four Cases
Authors: Kristine M. Cornejo, Lloyd Hutchinson, Maryann St. Cyr, Vania Nose, Patrick J. McLaughlin, A. John Iafrate, Peter M. Sadow
Journal: Endocrine Pathology (2015)
Abstract 1919: The Postoperative Systemic Inflammatory Response and Organ Injury are not Influenced by Bypass Temperature During Paediatric Open Heart Surgery: A Randomised Trial
Authors: Christian F Stocker, Lara S Shekerdemian, Daniel J Penny, Steve B Horton, Christian P Brizard
Journal: Circulation (2007)

Objectives: Systemic cooling during cardiopulmonary bypass (CPB) is widely used as a potential method of attenuating the CPB-related systemic inflammatory response syndrome (SIRS) and organ injury....
Long-Term Clinical Outcomes of Sirolimus- Versus Paclitaxel-Eluting Stents for Patients With Unprotected Left Main Coronary Artery Disease
Authors: Jong-Young Lee, Duk-Woo Park, Sung-Cheol Yun, Seung-Whan Lee, Young-Hak Kim, Cheol Whan Lee, Myeong-Ki Hong, Seong-Wook Park, Seung-Jung Park
Journal: Journal of the American College of Cardiology (2009)
Comparison Of Hevylite™ Assay and Plasma Cell Immunophenotyping For Response Evaluation and Residual Disease Characterisation In IgA Myeloma
Authors: Daniela Lakomy, Stephanie Lemaire-Ewing, Cedric Rossi, Jessica Borgeot, Jean-Noël Bastie, Ingrid Lafon, Marc Maynadie, Denis Caillot, Julien Guy
Journal: Blood (2013)
Abstract 21109: Bayesian Approach to Moderate Implausible Treatment Effects Observed in Trials Stopped Early: Lessons Learnt from JUPITER Trial.
Authors: Ryan P Morrissey, George A Diamond, Sanjay Kaul
Journal: Circulation (2010)

Background: The JUPITER trial was halted early after interim analysis showed a 44% risk reduction in the primary endpoint in primary-prevention patients randomly allocated to treatment with rosuvas...
Identification of Previously Unrecognized CD1d-Restricted Peripheral T Cell Lymphomas (PTCLs) in Mouse and Human Reveals Blocking Anti-CD1d Monoclonal Antibodies As a New Therapeutic Possibility in PTCLs
Authors: Emmanuel Bachy, Mirjam Urb, Gabriel Bricard, Shilpi Jayaswal, Remy Robinot, Alexandra Traverse-Glehen, Sophie Gazzo, Lucile Baseggio, Martine Ffrench, Paul Mondiere, Morgan Taillardet, Gilles Salles, Joel Lachuer, Olivier Hermine, Vahid Asnafi, Mikael Roussel, Thierry Lamy, Patrice Marche, Philippe Gaulard, Mitchell Kronenberg, Thierry Defrance, Laurent Genestier
Journal: Blood (2014)