tbuckley/cabot-search huggingface dataset:
Abstract 3254: Rhesus Monkey Derived Cardiospheres (CSps) for Myocardial Restoration After LAD Ligation in Mice
Authors: Andreas Martens, Ina Gruh, Dimitrios Dimitroulis, Sebastian Rojas, Ingrid Schmidt-Richter, Christian Rathert, Nawid Khaladj, Ulrich Martin, Axel Haverich, Ingo Kutschka
Journal: Circulation (2009)
充血性心力衰竭患者服用塞来昔布、罗非昔布或非甾体抗炎药的结果差异：以人群为基础的研究
Authors: Marie, Hudson, Hugues, Richard, Louise, Pilote, 郑文洁（译）, 董怡（校）
Journal: BMJ (2005)

目的：比较老年患者服用塞来昔布、罗非昔布或非甾体抗炎药的死亡和反复发作充血性心力衰竭的危险性，并决定塞来昔布、罗非昔布之间是否存在类效应的差异。设计：以人群为基础的回顾性队列研究。设置：Quebec数据库内医院出院总结和处方用药的资料。
Abstract 3436: Preprocedural N-Terminal Pro-B-Type Natriuretic Peptide Predicts Angiographic No-Reflow Phenomenon During Stent Implantation in Patients with Acute Myocardial Infarction
Authors: Seo Na Hong, Youngkeun Ahn, Nam Sik Yoon, Sun Ho Hwang, Kye Hun Kim, Sang Rok Lee, Young Joon Hong, Ju Han Kim, Myung Ho Jeong, Jeong Gwan Cho, Jong Chun Park, Jung Chaee Kang
Journal: Circulation (2006)

Background: The no-reflow phenomenon after primary percutaneous coronary intervention (PCI) is associated with greater infarct size, worse functional recovery, and higher incidence of complication ...
Expression kinetics of nucleoside-modified mRNA delivered in lipid nanoparticles to mice by various routes
Authors: Norbert Pardi, Steven Tuyishime, Hiromi Muramatsu, Katalin Kariko, Barbara L. Mui, Ying K. Tam, Thomas D. Madden, Michael J. Hope, Drew Weissman
Journal: Journal of Controlled Release (2015)
Standardisation of multilocus variable-number tandem-repeat analysis (MLVA) for subtyping of Salmonella enterica serovar Enteritidis
Authors: K L Hopkins, T M Peters, E de Pinna, J Wain
Journal: Eurosurveillance (2011)

Salmonella enterica serovar (S.) Enteritidis is an important cause of food-borne infection in Europe and the United States. Further subtyping of isolates is necessary to support epidemiological data for the detection of outbreaks and identification of the vehicle of infection. Multilocus variable-number tandem-repeat analysis (MLVA) is reportedly more discriminatory and produces data that are easier to share via databases than other molecular subtyping methods. However, lack of standardisation of the methodology and interpretive criteria for data analysis has meant that comparison of data between laboratories can be problematic. On the basis of MLVA profiles of 298 S. Enteritidis isolates received at the Health Protection Agency’s Salmonella Reference Unit and sequence analysis of selected isolates, we propose a MLVA scheme for S. Enteritidis based on five loci (SENTR4, SENTR5, SENTR6, SENTR7 and SE-3) that have been selected from previously published S. Enteritidis MLVA schemes. A panel of reference strains has been developed that can be used by laboratories to normalise their raw fragment data to actual fragment sizes. We also provide recommendations for analysing and interpreting MLVA data. We urge laboratories to consider implementing these guidelines, thereby allowing direct comparison of data between laboratories irrespective of the platform used for fragment analysis, to facilitate international surveillance and investigation of international outbreaks.
Tetrahydrobiopterin-dependent eNOS coupling attenuates vein graft atherosclerosis through inhibition of MCP-1 mediated monocyte recruitment to sites of vascular injury
Authors: Ziad A Ali, Christina A Bursill, Marianna Papaspyridonos, Asim A Akhtar, David R Greaves, Nicholas J Alp, Keith M Channon
Journal: Circulation (2007)
To what adaptive problems is human teaching a solution?
Authors: Mikołaj Hernik, György Gergely
Journal: Behavioral and Brain Sciences (2015)

Abstract We welcome Kline's systematic overview of teaching from a functional evolutionary perspective. However, Kline's framework does not provide satisfying characterization of the adaptive problems driving the evolution of teaching through communication found in humans, where the key function is better characterized in terms of licensing inferences to opaque generic content than in terms of overcoming shortages of access and attention.
Abstract 3967: Changing Trends in Obesity and Its Impact on Incidence of Atrial Fibrillation in Olmsted County, Minnesota 1980 2000
Authors: Yoko Miyasaka, Marion E Barnes, Bernard J Gersh, Stephen S Cha, Cynthia L Leibson, Kent R Bailey, Walter P Abhayaratna, James B Seward, Teresa S Tsang
Journal: Circulation (2006)
Abstract 2793: Comparison of Midregional Pro-atrial Natriuretic Peptide, B-type Natriuretic Peptide, and Amino-terminal Pro-B-type Natriuretic Peptide in Patients with Chronic Heart Failure: Influencing Factors, Detection of Left Ventricular Systolic Dysfunction, and Prediction of Death
Authors: Deddo Moertl, Martin Huelsmann, Joachim Struck, Andreas Gleiss, Alexandra Hammer, Nils G Morgenthaler, Andreas Bergmann, Rudolf Berger, Richard Pacher
Journal: Circulation (2007)

Background: Although natriuretic peptides are increasingly used for the management of chronic heart failure (CHF), there are sparse comparative data. Therefore, we compared the importance of influencing factors, the ability to detect left ventricular systolic dysfunction, and the prognostic power of midregional pro-atrial natriuretic peptide (MR-proANP), B-type natriuretic peptide (BNP), and aminoterminal pro-B-type natriuretic peptide (NT-proBNP) in patients with chronic heart failure. Methods and Results: MR-proANP, using a new assay directed at the midregion of aminoterminal-proANP, was compared with BNP and NT-proBNP, using conventional assays, in 797 patients with CHF. All three natriuretic peptides were independently influenced by left ventricular ejection fraction (LVEF), glomerular filtration rate (GFR), and the presence of ankle edema. Area under receiver-operator characteristic curves for detection of an LVEF &lt;40% were similar between MR-proANP (0.799 [0.753– 0.844]) and BNP (0.803 [0.757– 0.849]), and NT-proBNP (0.730 [0.681– 0.778]. During a median observation time of 68 months, 492 patients died. In multiple Cox regression analysis each natriuretic peptide was the strongest prognostic parameter among various clinical variables, but proportion of explained variation showed that NT-proANP was a significantly stronger predictor of death than NT-proBNP and BNP (Figure ). Conclusions: Despite similarities in influencing factors and detection of reduced LVEF, MR-proANP outperformed BNP and NT-proBNP in the prediction of death. A new assay technology and the high biological stability of MR-proANP are potential explanations for these findings.
Abstract B64: A Lys-Ala-Leu-Ala (KALA) repeated peptide modification in DNA nanoparticles of DOPE/CHEMS, follows GPCR mediated transgene expression in dendritic cell
Authors: Sharif Mohammad Shaheen, Hidetaka Akita, Hideyoshi Harashima
Journal: Cancer Research (2015)

Abstract Cellular uptake process of cationic peptide modified liposome is still obscured in perspective of cell biology. The mechanisms responsible for the internalization of oligo arginine, oligo-lysine, TAT and other arginine or lysine enriched peptide have focused on macropinocytosis. No information was reported about the uptake process of repeated cationic arginine or lysine (hydrophilic moiety) followed by leucine or alanine (hydrophobic moiety) with lipid bilayer based DNA nanocargoes. Here we orchestrated the concept of repeated lys-ala-leu-ala (KALA) peptide modified DNA-protamine-lipid nanoparticle, proclaimed a promising transfection activity in dendritic cell, following GPCR mediated endocytosis. Chemical inhibitors studies of chlorpromazine, Fillipin, and Amiloride did not support the concept of macropinocytosis, clathrin mediated endocytosis and cavaeola mediated endocytosis. Cetirizine hydrochloride, a GPCR blocker shut down the KALA mediated transgene expression. Confocal studies showed no liposomal uptake in KALA modification rather than R8 modification, which implies to receptor mediated endocytosis and thereby transgene expression. Low concentration of KALA pretreatment allowed a R8 MEND (usually non-expressed) to that of the same expression of KALA MEND and vice versa of high concentration KALA pretreatment. In a nut-shell performance of KALA ensured an engulfment of GPCR based endocytosis as well as GPCR activation thereby, that outcomes a boom transgene expression in dendritic cell. Citation Format: Sharif Mohammad Shaheen, Hidetaka Akita, Hideyoshi Harashima. A Lys-Ala-Leu-Ala (KALA) repeated peptide modification in DNA nanoparticles of DOPE/CHEMS, follows GPCR mediated transgene expression in dendritic cell. [abstract]. In: Proceedings of the AACR Special Conference on Pancreatic Cancer: Innovations in Research and Treatment; May 18-21, 2014; New Orleans, LA. Philadelphia (PA): AACR; Cancer Res 2015;75(13 Suppl):Abstract nr B64.
Reply to Farshad Pourmalek, Hamidreza Abdi, and Peter C. Black's Letter to the Editor re: Daniel P. Nguyen, Bashir Al Hussein Al Awamlh, Xian Wu, et al. Recurrence Patterns After Open and Robot-assisted Radical Cystectomy for Bladder Cancer. Eur Urol 2015;68:399–405
Authors: Daniel P. Nguyen, Douglas S. Scherr
Journal: European Urology (2015)
Abstract 20306: Comparison of Vascular Flow Reserve After Infrapopliteal Intervention Between Patients With Rest Pain and Patients With Tissue Loss
Authors: Masashi Fukunaga, Kenichi Fujii, Kojiro Miki, Machiko Nishimura, Ten Saita, Tetsuo Horimatsu, Akinori Sumiyoshi, Hiroto Tamaru, Takahiro Imanaka, Tohru Masuyama
Journal: Circulation (2014)

Purpose:  Several clinical stages of critical limb ischemia (CLI) are observed in daily practice. Although microcirculatory dysfunction might be correlated in those stages, it is not clear whether the differences of microvascular damage in patients with rest pain or tissue loss are existed. The aim of this study is to compare the physiological parameter in patients with rest pain to that in patients with tissue loss undergoing endovascular treatment (EVT) for isolated infrapopliteal lesions after EVTs.   Methods:  A total of 40 limbs of CLI patients with Rutherford-4 (R4) and Rutherford-5 (R5) undergoing EVT for isolated infrapopliteal lesions were included in this study prospectively. All lesions were treated by conventional balloon angioplasty alone. Initial success was defined as ≤30% residual diameter stenosis on angiogram. After the procedure, a pressure/temperature sensor-tipped guidewire was positioned in the proximal popliteal artery. By using thermodilution technique, mean transit time (Tmn) of a thermodilution-curve was obtained after bolus injections of 3 mL saline at baseline and at intra-arterial papaverine induced maximum hyperemia (30mg). It is generally recognized Tmn closely correlates with inverse of blood flow velocities. Vascular flow reserve (VFR) was calculated as resting Tmn divided by hyperemic Tmn.   Results:  Procedure success rate was 100%. VFR was successfully measured immediately after EVTs in all patients without complications. All patients were classified into 2 groups according to R4 (n=6) and R5 (n=34). No significant differences existed in baseline lesion characteristics between two groups. Although there was no significant difference in pre-VFR between R4 and R5 (3.9±2.4 versus 3.5±1.6, p=0.67), VFR after EVT was significantly lower R5 than R4 (8.6±3.7 versus 3.5±1.7, p   Conclusions:  Post-procedural VFR is restricted in patients with R5 due to the increase of resting flow velocity. Thus, not only reduced vessel flow during hyperemia because of microvascular impairment but also increased resting vessel flow from metabolic abnormalities might be mechanisms of CLI stage. Therefore, advanced lower limb clinical setting might be caused from a poor capability of microvasculature.
Vasovagal shock after insertion of intrauterine device. (Letter)
Authors: Menzies Dn
Journal: BMJ (1978)

With reference to your experts answer to a question on this subject (British Medical Journal December 24-31 1977 p. 1645) while it is to be hoped that all clinicians will use care and gentleness when dealing with patients and while this approach would no doubt reduce patients anxiety it remains a fact that inhibition of cardiac action as a result of pelvic examiantion can at times be dangerous.  This matter was dealt with by you in 1970 in a leading article which was followed by a letter from me pointing out the increased risk during the insertion of IUDs.  To attempt to remove a device while a patient is suffering from vasovagal shock could result in more serious complications.  The correct treatment is to inject atropine iv.  (Unless premedication has included the use of atropine even light anesthesia will not prevent this potentially fatal complication.) The value of the atropine administration can be confirmed by observing that the pulse rises to a normal value some 60 seconds after the injection.  The answer to the question put to your expert should have been: A syringe and solution of atropine suitable for intravenous administration. No clinic at which intrauterine contraceptives are inserted ought to be without this drug and other resuscitation equipment should be available.  As your expert writes Heaven forbid that any other resuscitative measures should need to be considered but this cannot mean that the possibility is to be ignored.  (Our expert replies: What Mr. Menzies suggests is sensible and reasonable though what I recommended should really be enough.  His suggestion that removal of the device might increase the shock is probably more theoretical than real. - Editor British Medical Journal)n(FULL TEXT)
THE EFFECT OF TACHYCARDIA ON THE BLOOD FLOW IN DOGS
Authors: Harold J. Stewart, J. Hamilton Crawford, A. B. Hastings
Journal: Journal of Clinical Investigation (1926)

The frequent.occurrence of tachycardia, both regular and irregular, in patients makes it desirable to have exact information as to the effect of these rhythms on the circulation.Up to the present few studies have been directed toward this end either in patients or in experimental aninals, because of the difficulty in the first place of obtaining samples of mixed venous blood and in the second place of inducing these rhythms under conditions which were not too far removed from normal conditions.Stewart (1) in a study of the oxygen saturation of the arterial and of the venous arm blood in patients during auricular fibrillation and after the return to the normal rhythm under quinidine sulphate, found that during the period of fibrillation the arterial oxygen satura- tion was practically unchanged, while that of the venous blood was decreased.It appeared therefore that the blood flow was slower during auricular fibrillation than during the normalrhythm.Gold- schmidt and Light (2) have shown that the oxygen saturation of the venous arm blood varies with temperature and to some extent with position, but the consistency in the changes which Stewart observed when these factors were taken into account make it seem unlikely that these two factors were responsible for them.Meakins (3) found that neither regular nor irregular tachycardia affected the oxygen saturation of the arterial blood in dogs.There is a difficulty however in the interpretation of Meakins' experiments, for the dogs were under paraldehyde anesthesia, the chests were open and the dogs were kept alive by means of artificial respiration.In cases
Abstract 101: Early Post-Resuscitative Care of Adult, Non-Traumatic Cardiopulmonary Arrests is Rarely Affected by Routine Head Computed Tomography
Authors: Maximilian Mulder, Nathaniel L Scott, Bradley A Bart, Mark Sprenkle, Fouad Bachour, Stephen Smith
Journal: Circulation (2010)

Background: The role of early head CT in the management of non-traumatic out-of-hospital cardiopulmonary arrests (NT-OHCA) is unclear. Objectives: To evaluate the diagnostic value of early head CT and its potential drawbacks in NT-OHCA. Methods: Between June 2007 – July 2009 all NT-OHCA patients aged >18, transported to our hospital, an urban, level one trauma teaching hospital were included. Data collected included demographics, initial rhythm, EKG, emergency department (ED) CT and outcomes. The study population was grouped into those who did and did not have an early CT. The data was analyzed in relation to initial rhythm, outcomes and changes or delay in treatment. Results: In total 201 NT-OHCA were transported to our ED during the study period; 125 (62%) were successfully resuscitated and admitted to the hospital, of which 86 (69%) had CT. Initial rhythm in those with CT was VT/VF in 33/86 (38%), PEA/asystole 48/86 (56%), and unspecified 5/86 (6%). Evidence of cerebral edema was found more commonly in...
Abstract # 10083: From Genotype to Phenotype at a Novel Cholesterol and Myocardial Infarction Locus
Authors: Kiran Musunuru, Alanna Strong, Maria Frank-Kamenetsky, Morgan L. Maeder, Stacey Thibodeau-Beganny, Ludmila Prokunina-Olsson, Jennifer L. Hall, Eric E. Schadt, Marju Orho-Melander, Ronald M. Krauss, J. Keith Joung, Chad A Cowan, Daniel J Rader, Sekar Kathiresan
Journal: Circulation (2010)
The reliability of three definitions of bizarre delusions
Authors: R L Spitzer, M B First, K S Kendler, D J Stein
Journal: American Journal of Psychiatry (1993)

This study was conducted to determine whether the interjudge reliability of the DSM-III-R concept of bizarre delusions could be improved by alternative definitions of the concept.Twelve raters evaluated 180 delusions of separate psychiatric patients according to the DSM-III-R and two alternative definitions of bizarre delusions.The kappas for the DSM-III-R definition and for one of the alternative definitions were 0.64 and 0.65, respectively; for the other alternative definition it was 0.45. All three definitions were highly intercorrelated, largely identifying the same cases.Neither of the alternative definitions of bizarre delusions was more reliable than the DSM-III-R definition. The reliability of the DSM-III-R definition, although only fair, is comparable to that of other important clinical concepts that play a major role in the DSM-III-R diagnostic criteria for psychotic disorders.
Epidemiology of fatal cases associated with pandemic H1N1 influenza 2009
Authors: L Vaillant, G La Ruche, A Tarantola, P Barboza, None for the epidemic intelligence team at InVS
Journal: Eurosurveillance (2009)

This article describes the characteristics of 574 deaths associated with pandemic H1N1 influenza up to 16 July 2009. Data (except from Canada and Australia) suggest that the elderly may to some extent be protected from infection. There was underlying disease in at least half of the fatal cases. Two risk factors seem of particular importance: pregnancy and metabolic condition (including obesity which has not been considered as risk factor in previous pandemics or seasonal influenza).
Abstract 16836: Pioglitazone Reduces Angiogenesis by Altering Mitochondrial Function and Reducing Hypoxia Inducible Factor-1 Activation
Authors: Peter Dromparis, Gopinath Sutendra, Lyndsay Bowers, Alois Haromy, Kyoko Hashimoto, Trevor H Stenson, Spencer Proctor, Evangelos D Michelakis, Michael S McMurtry
Journal: Circulation (2011)

Introduction: Thiazolidinediones (TZDs) used in type II diabetes are linked with adverse cardiovascular events by an unknown mechanism, including lower extremity revascularization. TZDs can affect mitochondria, which are oxygen sensors and therefore could regulate the angiogenic transcription factor hypoxia inducible factor 1 (HIF1) via mitochondrial derived α-ketoglutarate (αKG) and reactive oxygen species (mROS). We hypothesized that pioglitazone (PIO), a TZD, may impair angiogenesis through a mitochondrial-HIF1 dependent mechanism. Methods/Results: Human skeletal myocytes (hSMC) cultured at pO2 120 vs. 40 mmHg were treated with PIO (20 μ g/ml) for 24h. Compared to vehicle, PIO depolarized mitochondria, increased mROS and αKG in hypoxic hSMCs. PIO decreased HIF1 activity (nuclear translocation and decreased VEGF, a HIF1 regulated gene). In vitro, using a matrigel assay, PIO directly inhibited human microvascular endothelial cell (hMVEC) angiogenesis (tubule formation). To assess the paracrine effects and exclude the direct PIO effects on hMVEC, we used a Boyden chamber matrigel bioassay where hSMCs and hMVEC were separated by a cell impermeable membrane. Pre-treatment of hypoxic hSMCs with PIO had less angiogenesis than with vehicle. In vivo, neovascularization was assessed in diabetic (JCR:LP; n=20) and non-diabetic (SD; n= 22) rats. Hindlimb ischemia was induced, and the rats were treated with a clinically relevant PIO dose (10mg/kg/day) or placebo for 14 days. Ischemic hindlimb (gastrocnemius) perfusion was decreased in PIO treated animals (contrast enhanced ultrasound and Tc99m sestamibi micro CT-SPECT), which correlated with decreased angiogenesis (von Willebrand factor and lectin) in both diabetic and non-diabetic models. Conclusions: PIO alters mitochondrial function in hSMC, reducing HIF1 activation and inhibiting both paracrine/autocrine angiogenesis. PIO also impaired angiogenesis in diabetic and non-diabetic rats. Impairment of angiogenesis is undesirable in human diabetics with concomitant atherosclerotic vascular disease, and may be a mechanism for adverse effects of TZDs.
Abstract 8656: Age-Related Macular Degeneration and Incident Cardiovascular Disease: The Multi-Ethnic Study of Atherosclerosis
Authors: Antonio B Fernandez, Tien Y Wong, Ronald Klein, Dorothea Collins, Gregory Burke, Mary Frances Cotch, Barbara Klein, Mehran M Sadeghi, Jersey Chen
Journal: Circulation (2011)

Background: Age-related macular degeneration (AMD) has been linked to cardiovascular risk factors, but it is unclear whether or not AMD represents a marker for subsequent coronary heart disease (CHD) and cardiovascular disease (CVD) events, including stroke. Aim: To determine whether AMD is a risk indicator for CHD/CVD events independent of other known risk factors in a multi-ethnic cohort. Methods: Retinal photographs from participants in the Multi-Ethnic Study of Atherosclerosis (MESA) without known CVD were evaluated for AMD. A Cox proportional hazard regression model was used to examine the association between AMD with subsequent CHD/CVD events, adjusting for clinical CVD risk factors. Additional analyses were conducted evaluating the strength of association between AMD and CHD/CVD stratifying by patient age and race. Results: Among 5951 participants with gradable retinal photographs, there were 895 participants with AMD. Over a mean follow-up period of 5.4 years, there was no statistically significant difference in incident CHD or CVD between the AMD and non-AMD groups (5.0% vs. 3.9%, p=0.13 for CHD and 6.6 vs. 5.5%, p=0.19 for CVD, respectively). In Cox regression models adjusting for CVD risk factors, there were no significant relationship between presence of any AMD and CHD/CVD events (HR=0.99, 95% CI 0.74-1.33, p=0.97). No significant association was found between subgroups of early AMD or late AMD and incident CHD/CVD events. Conclusions: In persons without a history of cardiovascular disease, AMD was not found to be significantly associated with an increased risk of CHD or CVD events.
Medical and legal problems in psychiatric coding under the DSM and ICD systems
Authors: I N Perr
Journal: American Journal of Psychiatry (1984)

The various diagnostic systems in psychiatry have differed in their terminology and associated numerical codes. Lack of attention to coding variations in the DSM and ICD systems during the review of patient records can lead to misinterpretation and confusion; reliance on historical or statistical studies that use differing systems may be questionable. Two cases illustrate the problems caused by lack of awareness of these factors. Specification by the psychiatrist of both the diagnostic system used and the appropriate revision or edition can lessen communication error or misunderstanding.