tbuckley/cabot-search huggingface dataset:
A Rude Awakening
Authors: Richard S. Panush
Journal: JAMA (1997)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
ACUTE MASTOIDITIS AFTER SUBSIDENCE AND WITHOUT RECURRENCE OFTYMPANIC INFLAMMATION.
Authors: HIRAM WOODS
Journal: JAMA (1901)

The symtomatology of acute mastoiditis is so generally known that it is almost useless to write of it. Two modes of onset are most common. While otorrhea continues, or increases in amount, mastoid symptoms develop. This, in my experience, is the rule. Less frequently otorrhea ceases, perhaps gradually, more commonly, suddenly, with simultaneous lighting up of mastoid disease. Politzer, in his text-book, says that only once has he seen suppuration in the tympanic cavity cease, while the symptoms of inflammation in the mastoid continued undiminished. And again he states: "Occasionally cases are observed in which, several days after local symptoms disappear, abscess formation in the mastoid process is manifested." In the clinic of the Presbyterian Eye, Ear and Throat Hospital of Baltimore, so far as I find recorded, there have been only two such cases in twenty-two years: one, a child three years ago, where there was no otorrhea; the
Effect of Several Drugs on Gastric Potential Difference in Man
Authors: H. S. Murray, M. P. Strottman, A. R. Cooke
Journal: BMJ (1974)

Measurement of gastric mucosal potential difference was used to study the effect on the gastric mucosal barrier in six volunteer subjects of several drugs known to provoke ulcers. Potential differences were also recorded in nine patients with rheumatoid arthritis being treated with long-term aspirin and five patients on long-term prednisone. Unbuffered aspirin and ethanol "broke" the barrier as shown by a rapid fall in potential difference. The effects of aspirin were dose related, with 600 mg causing a greater reduction than 300 mg. The effects of aspirin and ethanol given together were additive and caused the greatest fall in potential difference. Sodium acetylsalicylate did not alter the normal potential difference. Indomethacin, phenylbutazone, and prednisone all failed to cause any change in potential difference. The patients on long-term aspirin and prednisone had readings within the normal range and responded the same as normal subjects to an acute challenge. These studies show that aspirin and ethanol will damage the gastric mucosal barrier but that indomethacin, phenylbutazone, and prednisone do not.
Correction: Authors of Session Abstract
Authors: ROBERT A. CHAHINE
Journal: Annals of Internal Medicine (1972)

Letters, Comments, and Corrections1 December 1972Correction: Authors of Session AbstractROBERT A. CHAHINE, M.D.ROBERT A. CHAHINE, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-77-6-1005_3 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: I wish to point out an error in the list of authors for the Session abstract "Complications of Coronary Arteriography: Comparison of the Brachial to the Femoral Approach" (Ann Intern Med76:862). The list of authors as printed is incomplete. The correct authorship appeared in the abstracts booklet for the Fifty-Third Annual Session of the American College of Physicians, Atlantic City, N.J., 17-21 April 1972. Drs. Chahine, Herman, and Gorlin, who are from Peter Bent Brigham Hospital in Boston, were listed as coming from Miami, Fla. In addition, four other co-authors, namely Drs. Abbasi, Eber, Iyengar, and... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 December 1972Volume 77, Issue 6Page: 1005-1006KeywordsAngiographyStable coronary artery disease Issue Published: 1 December 1972 PDF DownloadLoading ...
Secreted Frizzled-Related Protein 4 Reduces Insulin Secretion and Is Overexpressed in Type 2 Diabetes
Authors: Taman Mahdi, Sonja Hänzelmann, Albert Salehi, Sarheed J. Muhammed, Thomas M. Reinbothe, Yunzhao Tang, Annika S. Axelsson, Yuedan Zhou, Xingjun Jing, Peter Almgren, Ulrika Krus, Jalal Taneera, Anna M. Blom, Valeriya Lyssenko, Jonathan Lou S. Esguerra, Ola Hansson, Lena Eliasson, Jonathan Derry, Enming Zhang, Claes B. Wollheim, Leif Groop, Erik Renström, Anders H. Rosengren
Journal: Cell Metabolism (2012)
TREATMENT OF INFLUENZA
Authors: Julius Martinson
Journal: JAMA (1918)

<h3>To the Editor:</h3> —During the recent epidemic of influenza I saw a great number of cases in which one of the most prominent symptoms was hemorrhage from the nose, which lasted usually several days and was often profuse. What struck me in these cases was that none of the patients developed pneumonia and all recovered.... Does this bleeding give us a hint to employ bloodletting more frequently in cases in which pneumonia is suspected or beginning to develop?
X-ray Burns in Industry
Authors: J. T. B. Bain, J. E. MacCabe
Journal: BMJ (1962)

Four cases of industrial x-ray burns, seen by industrial medical officers, which occurred in research and analytical workers using x-ray diffraction and x-ray spectrometer machines, are described. In 2 of the cases an x-ray fluorescent spectrometer was partly dismantled with the beam on, and fairly severe burns to the right hand resulted in each case. These healed uneventfully, if slowly. In the 3rd case a small burn occurred on the right hand after a few seconds' exposure while adjusting a beam aperture on an x-ray diffraction apparatus, the beam again being on. This also healed uneventfully. In the 4th case, however, the outcome was more serious; an analytical worker adjusted the beanr of an x-ray diffraction apparatus, the machine being on. An unknown, but large, dose was received. Burns of the fingers appeared in a few weeks and failed to heal. Six months after exposure it was necessary to amputate the distal parts of the index and middle fingers. All the machines were standard pieces of apparatus and visible warning lights were on. Each incident was due to adjustment of the apparatus despite this warning. Although chemists and physicists may be theoretically conversant with the nature and properties of x-more » ray beams, they may lack a sufficient realization of the dangers of x-ray equipment. (H.H.D.)« less
Phenotypic characterization of idiosyncratic drug-induced liver injury: The influence of age and sex
Authors: M. Isabel Lucena, Raúl J. Andrade, Neil Kaplowitz, Miren García‐Cortes, M. Carmen Fernández, Manuel Romero‐Gomez, Miguel Bruguera, Hacibe Hallal, Mercedes Robles‐Diaz, Jose F. Rodriguez‐González, Jose Maria Navarro, Javier Salmeron, Pedro Martinez‐Odriozola, Ramón Pérez‐Alvarez, Yolanda Borraz, Ramón Hidalgo
Journal: Hepatology (2009)

Increased age and female sex are suggested risk factors for drug-induced hepatotoxicity (DILI). We studied the influence of these variables on the propensity to develop DILI, as well as its clinical expression and outcome. All cases of DILI submitted to the Spanish Registry between April 1994 and August 2007 were analyzed. Six hundred three DILI cases (310 men; mean age, 54 years) showed a similar sex distribution, reaching two peaks in the 40- to 49-year-old and 60- to 69-year-old age groups. No cases were recorded in the 20- to 29-year-old group. Patients aged ≥60 years accounted for 46% of the cases, with a male predominance (158 males, 118 females; P= 0.009), as opposed to younger patients. Older age was independently associated with cholestatic type of injury (odds ratio for an age interval for 1 year: 1.024 [95% confidence interval: 1.010-1.038]; male/female ratio, 1:2;P = 0.001) and younger age with hepatocellular damage (odds ratio: 0.983 [95% confidence interval: 0.972-0.994]; female/male ratio, 1:2;P = 0.002). In the mixed group, no age effect was evident. Outcome with fulminant liver failure/liver transplantation was more frequently encountered in women (P < 0.01). Conclusion:Neither older age nor female sex are predisposing factors to overall DILI. However, older age is a determinant for cholestatic damage with a male predominance, whereas younger age is associated with cytolytic damage and a female overrepresentation. Women distinctly exhibit the worst outcome. Knowledge of these phenotypic associations could guide differential diagnosis and attribution of causality in DILI. (HEPATOLOGY 2009;49:2001–2009.)
Oral 12, Acute haemorrhagic oedema of infancy: an important differential diagnosis to nonaccidental injury
Authors: S. Hann, R.G. Goodwin
Journal: British Journal of Dermatology (2007)

Journal Article Oral 12, Acute haemorrhagic oedema of infancy: an important differential diagnosis to nonaccidental injury Get access S. Hann, S. Hann Royal Gwent Hospital, Newport, U.K. Search for other works by this author on: Oxford Academic Google Scholar R.G. Goodwin R.G. Goodwin Royal Gwent Hospital, Newport, U.K. Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 156, Issue 6, 1 June 2007, Page 1407, https://doi.org/10.1111/j.1365-2133.2007.07876_12.x Published: 01 June 2007
Persistent Cryptococcus neoformans Infection of the Prostate after Successful Treatment of Meningitis
Authors: Robert A. Larsen
Journal: Annals of Internal Medicine (1989)

Study Objective: To assess the frequency of persistent Cryptococcus neoformans infection in patients with the acquired immunodeficiency syndrome (AIDS) after receiving apparently adequate treatment for meningitis. Design: Blood, urine, and cerebrospinal fluid were cultured at the conclusion of primary therapy to assess the adequacy of treatment. Setting: Outpatient clinics at three medical centers. Patients: Patients had C. neoformans grown in culture from cerebrospinal fluid. Primary therapy consisted of either 2.0 g of amphotericin B alone; 6 weeks of combination therapy with flucytosine; or, if flucytosine was poorly tolerated, an adjusted minimum total amphotericin B dose. To meet criteria for adequate treatment of meningitis all patients had two sequential cerebrospinal fluid samples which were culture negative. Measurements and Main Results: Nine of forty-one patients grew C. neoformans from urine after completion of primary treatment, but none had urinary symptoms. Fungi were visualized in expressed prostatic secretions in 4 of these patients. One patient refused further treatment and developed cryptococcemia within 5 weeks. Three patients received additional amphotericin B; all had persistent funguria without systemic relapse. Six patients received fluconazole; 4 became urine culture negative, and 2 had systemic relapse. Conclusion: The persistence of urinary C. neoformans after adequate therapy for meningitis suggests that the urinary tract (probably the prostate) is a sequestered reservoir of infection from which systemic relapse may occur.
Tuberous sclerosis and polycystic kidney disease.
Authors: D W Webb, M Super, I C Normand, J P Osborne
Journal: BMJ (1993)

contracts than they received in 1992-3, without a parallel increase in activity.Last year, providers' deadlines for issuing prices slipped several times, causing chaos to purchasers.East Birmingham's last contract was signed in August instead of the preceding March.The new regional edict is: "There are deadlines; we do not accept changes thereafter."Howard Shaw was less enthusiastic than his director of corporate management about the workings of the intemal market."We're two months ahead of last year, but I'm not sure we've leamt that much.I don't think we've understood how to play the market, or even if the market's to be played because of the whole complexity of the system.We've got 20 units providing 50 specialties-for inpatients, day cases, and outpatients.There's a price and a volume for each of these, and you can have price and volume variance on all these contracts.So you've got this mass of data, and we can't make head or tail of it."His opinion was echoed by Robert Marriott.He did not think that you could decide at this stage whether the outcome of the reforms was good or bad."Mostly it seems confusion-because of the demands being made on both purchasers and providers."Perhaps in a year's time things will be clearer.
Response to Shandro et al.
Authors: Carry M. Renders, Gerlof D. Valk
Journal: Diabetes Care (2002)

We read with interest the letter from Shandro et al. (1) in this issue of Diabetes Care . In our systematic review, in which we reviewed the effectiveness of interventions targeted at health care professionals and/or the structure of care to improve the management of diabetes in primary care, outpatient, and community settings, only a few of the studies that were included sent reminders to patients for follow-up visits. In these studies, …
ANTIGENS IN IMMUNITY
Authors: J. J. Miller, G. J. V. Nossal
Journal: The Journal of Experimental Medicine (1964)

The localization of antigen in primary follicles and germinal centers of rat popliteal lymph nodes described previously using I125- and I125-labeled antigen has been confirmed by direct staining with fluorescent antibodies. A fine web of phagocytic reticulum in primary follicles was found to be responsible for antigen localization in this area. The nature of this web was confirmed by studies of the localization of colloidal carbon. This unique feature of primary follicles is discussed in relation to its importance in the induction of immune responses, our belief being that the great surface area of antigen retaining cytoplasm in primary follicles is responsible for the appearance of germinal centers in these particular parts of the node.
Secondary cancers, comorbidities and mortality associated with nitrogen mustard therapy in patients with mycosis fungoides: a 30-year population-based cohort study
Authors: L.M. Lindahl, M. Fenger-Grøn, L. Iversen
Journal: British Journal of Dermatology (2013)

Topical nitrogen mustard is a widely used therapy in patients with mycosis fungoides (MF). However, it remains controversial whether nitrogen mustard therapy is associated with increased risk of secondary cancers and chronic pulmonary diseases in patients with MF.To assess the risk of secondary cancers, comorbidities, mortality and cause-specific mortality in patients with MF treated with nitrogen mustard compared with patients not receiving this treatment.Linking the Danish nationwide registries in a 30-year population-based cohort study, we compared 110 patients with MF from a regional Danish centre using nitrogen mustard treatment with 193 patients from Danish centres not using nitrogen mustard. The two cohorts were compared by Cox regression analysis.Overall, secondary cancers were not significantly increased [hazard ratio (HR) 0.84, 95% confidence interval (CI) 0.46-1.56], and subanalyses showed no significantly increased risk of nonmelanoma skin cancers, malignant melanomas or cancers in the respiratory organs in the nitrogen mustard-treated cohort. Furthermore, we found no significantly increased risk of any category of comorbidity, including chronic pulmonary diseases, in patients treated with nitrogen mustard (HR 0.93, 95% CI 0.48-1.81). Moreover, mortality and cause-specific mortality did not significantly differ between the two cohorts.This study does not support any previous suspicion of increased risk of secondary cancers and chronic pulmonary diseases among patients with MF treated with nitrogen mustard. Furthermore, mortality and cause-specific mortality were not influenced by nitrogen mustard treatment. Thus our findings indicate that topical nitrogen mustard is a safe therapy in patients with MF.
Dietary Intervention in Infancy and Later Signs of Beta-Cell Autoimmunity
Authors: Mikael Knip, Suvi M. Virtanen, Karri Seppä, Jorma Ilonen, Erkki Savilahti, Outi Vaarala, Antti Reunanen, Kari Teramo, Anu-Maaria Hämäläinen, Johanna Paronen, Hans-Michael Dosch, Timo Hakulinen, Hans K. Åkerblom
Journal: New England Journal of Medicine (2010)

Early exposure to complex dietary proteins may increase the risk of beta-cell autoimmunity and type 1 diabetes in children with genetic susceptibility. We tested the hypothesis that supplementing breast milk with highly hydrolyzed milk formula would decrease the cumulative incidence of diabetes-associated autoantibodies in such children.In this double-blind, randomized trial, we assigned 230 infants with HLA-conferred susceptibility to type 1 diabetes and at least one family member with type 1 diabetes to receive either a casein hydrolysate formula or a conventional, cow's-milk-based formula (control) whenever breast milk was not available during the first 6 to 8 months of life. Autoantibodies to insulin, glutamic acid decarboxylase (GAD), the insulinoma-associated 2 molecule (IA-2), and zinc transporter 8 were analyzed with the use of radiobinding assays, and islet-cell antibodies were analyzed with the use of immunofluorescence, during a median observation period of 10 years (mean, 7.5). The children were monitored for incident type 1 diabetes until they were 10 years of age.The unadjusted hazard ratio for positivity for one or more autoantibodies in the casein hydrolysate group, as compared with the control group, was 0.54 (95% confidence interval [CI], 0.29 to 0.95), and the hazard ratio adjusted for an observed difference in the duration of exposure to the study formula was 0.51 (95% CI, 0.28 to 0.91). The unadjusted hazard ratio for positivity for two or more autoantibodies was 0.52 (95% CI, 0.21 to 1.17), and the adjusted hazard ratio was 0.47 (95% CI, 0.19 to 1.07). The rate of reported adverse events was similar in the two groups.Dietary intervention during infancy appears to have a long-lasting effect on markers of beta-cell autoimmunity--markers that may reflect an autoimmune process leading to type 1 diabetes. (ClinicalTrials.gov number, NCT00570102.).
Organic-Mercury Food Poisoning
Authors: Thomas B. Eyl
Journal: New England Journal of Medicine (1971)

THE increasing concern over environmental mercury contamination throughout the world was spotlighted by the International Conference on Environmental Mercury Contamination held September 30 to October 2, 1970, at the University of Michigan.The symptoms of alkylmercury poisoning, contrary to those of inorganic mercury intoxication, involve chiefly the central nervous system.1 2 3 4 5 6 7 More or less in order of ascending severity, they include the following: paresthesia of mouth, lips, tongue, hands, feet; inability to concentrate, lack of interest at home and at work, weakness, apathy and extreme fatigue; difficulty in swallowing and in articulating words; concentric constriction of visual fields ("tunnel vision"), with . . .
A New Pattern of Drug Addiction.
Authors: Jacob Schut
Journal: Annals of Internal Medicine (1973)

Meeting Abstracts1 May 1973A New Pattern of Drug Addiction.Jacob Schut, M.D., Barbara A. Naglin, Karen File, Theodora WohlmuthJacob Schut, M.D.Search for more papers by this author, Barbara A. NaglinSearch for more papers by this author, Karen FileSearch for more papers by this author, Theodora WohlmuthSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-78-5-814_5 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptA comparison of admissions over a 4-year period in a large outpatient methadone maintenance facility showed some startling patterns regarding initial drug use and drug-taking behavior. First, there has been a strong shift away from the use of marijuana as the first drug used, with the narcotics, especially heroin, significantly replacing marijuana. Secondly, a significant majority of patients began using their first narcotic before their twenty-first birthday, becoming addicted, therefore, at a much earlier age than previously noted. Thirdly, more than three fourths of patients admitted used drugs other than heroin in the 2-month period before treatment, a complete reversal... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Philadelphia, Pennsylvania. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 May 1973Volume 78, Issue 5Page: 814-815KeywordsBehaviorDrug addictionDrugsHeroinMarijuanaOutpatients Issue Published: 1 May 1973 PDF DownloadLoading ...
Letter: Aortic valvular disease and valve replacement.
Authors: A Lewis
Journal: Circulation (1975)

We are aware that Gorlin's formula underestimates mitral valve area in the presence of regurgitation; that is why we indicated the degree of regurgitation in our table.We con- sider severe mitral stenosis the dominant lesion in patients 5, 7, 9, 11, and 16 in the table.We did not consider cases with significant mitral regurgitation as having severe mitral stenosis except for patient #16 who had a flat diastolic slope on the echocardiogram.Had we excluded this last case, the message would not have been altered.Since our paper has been published we have received per- sonal communications from other institutions confirming our observations, albeit in a small number of cases.We would like to reemphasize that posterior motion of the posterior mitral leaflet is seen in a small minority of cases with mitral stenosis, including moderate and severe stenosis.Echocardiographers should be aware of this in order to avoid misdiagnosis.
Spectrin and Spherocytosis
Authors: Stephen B. Shohet
Journal: New England Journal of Medicine (1982)

Knowledge of the structure and function of the red-cell membrane has increased during the past several years. The advent of highly sensitive methods for protein preparation and purification has enabled us to identify structural membrane components that may have important functional roles. In particular, the concept of a "membrane skeleton" of proteins that may modulate cell shape and deformability has emerged. This skeleton appears to be a moderately dense meshwork of interconnected proteins immediately below the lipid bilayer. In this position it supports the bilayer and acts as a scaffolding for that otherwise weak and ephemeral structure.The strength of . . .
Secretoneurin as a marker for hypoxic brain injury after cardiopulmonary resuscitation
Authors: Julia Hasslacher, Georg Franz Lehner, Ulrich Harler, Ronny Beer, Hanno Ulmer, Rudolf Kirchmair, Reiner Fischer-Colbrie, Romuald Bellmann, Stefan Dunzendorfer, Michael Joannidis
Journal: Intensive Care Medicine (2014)