tbuckley/cabot-search huggingface dataset:
Abstract 1749: Endothelial Progenitor Cells and Vascular Endothelial Function Follow a Parallel Circadian Pattern
Authors: Ibhar Al Mheid, Konstantinos Aznaouridis, Riyaz Patel, Farheen Shirazi, Diane J Sutcliffe, W. R Taylor, R. W Alexander, Arshed Quyyumi
Journal: Circulation (2008)

Background: Endothelial Progenitor Cells (EPCs) are mobilized in response to endothelial injury and their counts correlate with endothelial function and cardiovascular risk burden. This rare cell population can be characterized by either flow cytometric analysis or mononuclear cell culture and colony counting, however, the 24-hour circadian variation and inter-relation of EPC measures with endothelial function remain unknown. We hypothesized that EPC levels and endothelial function will have a similar circadian variation. Methods: In 12 healthy subjects (8 men, 42 ± 18 yrs), we investigated the circadian variation of: 1-circulating cells positive for: CD34, CD133 andCD34, the number of colonies formed by culturing mononuclear cells utilizing a 7-day assay and flow-mediated vasodilation utilizing brachial artery reactivity at 8am, noon, 4pm, 8pm, midnight, 4am and 8am. Results: ANOVA for repeated measures over 24 hours indicated significant changes in the number of colony counts (p &lt; .001, highest at midnight). Similarly, flow-mediated vasodilation was highest at midnight (p &lt; .001). In contrast, CD34+ and dual positive CD34+ /CD133+ cell counts peaked a little earlier at 8 pm (8 pm vs.8 am p = .07 and .01 for paired t-tests, respectively). (Figure ) Conclusion: Endothelial function and EPCs estimated as colony forming units peak at midnight and are lower at other times of the day. The highest counts of circulating progenitors are seen at 8pm. There is a parallel change in circulating EPCs and vascular endothelial function during a 24-hour period, with lower levels in the morning hours.
Ribavirin and Use of Clotting Factors in Patients With Hemophilia and Chronic Hepatitis C
Authors: Takashi Honda, Hidenori Toyoda, Kazuhiko Hayashi, Yoshiaki Katano, Motoyoshi Yano, Isao Nakano, Kentaro Yoshioka, Hidemi Goto, Koji Yamamoto, Junki Takamatsu
Journal: JAMA (2005)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
FDA Okays Drug to Reduce Double Chins
Authors: Rita Rubin
Journal: JAMA (2015)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Abstract 6165: Increased Circulating Cd62e+ Endothelial Microparticles Levels Predict Poor Outcome in Pulmonary Hypertension Patients
Authors: Nicolas J Amabile, Yerem Yeghiazarians, Vivian Chang, Lauren Damon, Christian Heiss, Franca S Angeli, Eduardo J Rame, Dana McGlothlin, William Grossman, Teresa DeMarco
Journal: Circulation (2008)

Pulmonary hypertension (PH) is characterized by vascular remodeling and endothelial dysfunction. Levels of endothelial (EMPs) and leukocytes-derived (LMPs) microparticles, which are submicron membrane fragments shed from damaged or activated cells, have been shown to be significantly increased in PH patients compared to healthy controls. We hypothesized that the levels of circulating endothelial and leukocytes-MPs could predict outcome in these patients. Patients undergoing right heart catheterization for untreated pre-capillary PH, and without any conditions associated with increased circulating MPs levels, were eligible for the study. The following were measured at the time of enrollment: body mass index, mean pulmonary artery pressure (mPAP), C reactive protein (CRP)and BNP. CD62e+, CD144+, and CD31+/CD41− EMPs and CD45+ LMPs were measured using flow cytometry in platelet-free plasma from venous blood. After inclusion, patients were treated at the discretion of the physician and prospectively followed for 12 months. The primary endpoint assessed was the combined occurrence of death and readmission for right heart failure (RHF) or worsening of RHF symptoms. Seven of 21 patients (mean age=54.1±3.5y/62% female) experienced an adverse clinical event during this period. These patients had significantly higher baseline levels of CD62e+ EMPs (581±123 vs. 202±52 ev/μL, p=0.003), CD45+ LMPs (500±141 vs. 247±44 ev/μL, p=0.03) and CRP (9.9±2.2 vs. 3.8±0.7 IU/L, p=0.004) than patients without events, whereas no difference was observed for CD31+/CD41− and CD144+ EMPs, mPAP or baseline plasma BNP values. Moreover, CD62e+ levels correlated significantly with CD45+ LMPs (r=0.70, p=0.001). Multivariate analysis revealed that 4th quartile levels of CD62e+ EMPs was an independent predictor of adverse event after adjustment for CRP, CD45+ LMPs levels, body mass index and gender. These preliminary results show that high levels of circulating CD62e+ EMPs prior to treatment, but not other MPs subpopulations, are associated with clinical adverse events in PH subjects. These data suggest that this new biological parameter may be useful to predict outcome in patients with PH.
ACCF 2008 Training Statement on Multimodality Noninvasive Cardiovascular Imaging
Authors: James D. Thomas, William A. Zoghbi, George A. Beller, Robert O. Bonow, Matthew J. Budoff, Manuel D. Cerqueira, Mark A. Creager, Pamela S. Douglas, Valentin Fuster, Mario J. Garcia, David R. Holmes, Warren J. Manning, Gerald M. Pohost, Thomas J. Ryan, William A. Van Decker, Susan E. Wiegers
Journal: Journal of the American College of Cardiology (2008)
Abstract P335: High-sensitive C-reactive Protein and Risk of Undiagnosed and Incident Diabetes: The Singapore Chinese Health Study
Authors: An Pan, Jian-Min Yuan, Woon-Puay Koh
Journal: Circulation (2015)

Introduction: There has been growing evidence that elevated levels of C-reactive protein (CRP), as a biomarker of inflammation, are associated with increased risk of diabetes. However, previous prospective studies were mostly conducted among Caucasians, and few were done in Chinese. Thus, we assessed the hypothesis that elevated CRP levels are related to increased risk of type 2 diabetes among Chinese adults residing in Singapore. Methods: The Singapore Chinese Health Study (SCHS) is a population-based cohort that recruited 63,257 Chinese adults aged 45-74 years during 1993 and 1998, and morning blood samples were collected from about 32,000 participants during the first follow-up visit (1999-2004). In this diabetes case-control study nested within SCHS, all eligible participants were free of diagnosed diabetes, cardiovascular disease and cancer at blood collection, and 571 cases subsequently reported to have diabetes at the follow-up II visit (2006-2010), while 571 controls were matched to cases for age (±3 years) and date (±6 months) of blood collection, sex and dialect group and remained free of diabetes, cardiovascular disease at the follow-up II visit. Plasma high-sensitive CRP (hs-CRP) concentrations were assayed, and conditional logistical regression models were used to calculate the odds ratios (ORs) and 95% confidence intervals (CIs). Results: The mean (SD) concentrations of hs-CRP was 2.79 (2.65) and 1.86 (2.03) mg/L, respectively, in cases and controls (P&lt;0.001). After controlling for matching factors, education level, smoking status, alcohol intake, physical activity, baseline hypertension, fasting status, body mass index, triglycerides and HDL cholesterol, the ORs (95% CIs) across quartiles of hs-CRP were 1.00 (ref), 1.25 (0.79-1.98), 1.23 (0.78-1.95), and 1.73 (1.11-2.69; P for trend=0.01). Among the cases, there were 279 subjects who had HbA1C ≥6.5% at the time of blood collection and thus classified as undiagnosed diabetes, and the other 292 subjects had HbA1C &lt;6.5% at blood collection and were classified as incident diabetes. In the undiagnosed diabetes case-control sets, the ORs (95% CIs) across quartiles of hs-CRP were 1.00 (ref), 1.23 (0.59-2.56), 2.26 (1.10-4.66), and 2.46 (1.26-4.83; P for trend=0.009); while in the incident diabetes case-control sets, the ORs (95% CIs) were 1.00 (ref), 1.22 (0.63-2.36), 0.73 (0.38-1.41), and 1.25 (0.65-2.42; P for trend=0.39). Conclusions: In this prospective nested case-control study of Chinese adults, elevated CRP levels are not independently associated with increased risk of incident diabetes. The positive association between CRP and undiagnosed diabetes suggests that CRP may parallel with hyperglycemia. Our results do not support the independent role of CRP in the development of type 2 diabetes in Chinese population.
Abstract 12776: Non-ST-segment Elevation Acute Coronary Syndromes Patients without Angiographically Detected Obstructive Coronary Artery Disease are Low-risk but Not No-risk: A Meta-analysis of 8 Trials of 37,101 Patients
Authors: Keith A Fox, Jennifer A White, Gaetano M DeFerrari, Robert P Giugliano, Pierluigi Tricoci, Harmony R Reynolds, Judith S Hochman, C. M Gibson, Pierre Theroux, Robert A Harrington, Frans Van de Werf, Harvey D White, Robert M Califf, L. K Newby
Journal: Circulation (2010)
Midterm results after the arterial switch operation for transposition of the great arteries with intact ventricular septum: clinical, hemodynamic, echocardiographic, and electrophysiologic data.
Authors: G Wernovsky, T J Hougen, E P Walsh, G F Sholler, S D Colan, S P Sanders, I A Parness, J F Keane, J E Mayer, R A Jonas
Journal: Circulation (1988)

Although the short-term results of atrial level repair of transposition of the great arteries (TGA) are satisfactory, longer follow-up has disclosed a significant incidence of systemic right ventricular dysfunction and rhythm disturbances. The arterial switch operation (ASO) may represent a major improvement by restoring the left ventricle as the systemic ventricle and avoiding extensive atrial surgery. We have prospectively evaluated 49 consecutive survivors of ASO for TGA with intact ventricular septum (IVS) by clinical examination, echocardiography, cardiac catheterization, ambulatory electrocardiographic monitoring, and invasive electrophysiologic studies. The mean length of follow-up has been 29 +/- 14 (SD) months after surgery. All children are currently asymptomatic and on no medications. Severe supravalvular pulmonary stenosis (greater than 60 mm Hg) was present in five children, all of whom have undergone reoperation. No patient has severe supravalvular aortic obstruction. Mild degrees of supravalvular pulmonary or aortic obstruction have not progressed. Seven children (14%) have trivial or mild aortic regurgitation. Two children have proximal occlusion of the left anterior descending coronary artery with adequate retrograde collateral perfusion. One child had an electrocardiographic pattern of inferior myocardial infarction without evidence of ventricular dysfunction. Systemic (left) ventricular function is normal as measured by end-diastolic pressure (mean 7 +/- 6 mm Hg), ejection fraction (mean 68 +/- 6%), end-diastolic volume (mean 101 +/- 22% of predicted normal), and cardiac index (mean 4.7 +/- 1.3 liters/min/m2). Only one patient has sinus node dysfunction. There have been no late deaths. These early results are encouraging. We conclude that the arterial switch operation is currently the procedure of choice for neonates with TGA and IVS.
Thrombin-Induced Platelet Secretion
Authors: M. A. Shuman, M. Botney, J. W. Fenton
Journal: Journal of Clinical Investigation (1979)

We have studied the interaction between thrombin and washed, human platelets using prostacyclin, a reversible inhibitor of platelet secretion. The effect of thrombin is limited to those reactions that are not inhibited by an increased concentration of platelet cyclic adenosine 3′,5′-monophosphate, because prostacyclin is a potent inducer of the latter. Prostacyclin-treated platelets were briefly (15-30 s) exposed to low concentrations of human thrombin (0.01-0.2 U/ml). After removal of the prostacyclin and thrombin, the platelets were incubated with fresh thrombin. Although they had not undergone the release reaction after the first thrombin incubation, these platelets had a diminished capacity to secrete [3H]serotonin when exposed to thrombin the second time. Refractoriness was concentration dependent: the higher the initial thrombin concentration, the greater the degree of inhibition of serotonin secretion on subsequent thrombin exposure. Inhibition was closely related to the ability of thrombin to induce platelet secretion and not to its esterase or fibrinogen clotting activity. Diisopropyl fluorophosphate-inactive thrombin did not induce refractoriness. Refractoriness to thrombin did not increase when the time of the initial incubation with thrombin was lengthened, nor was it reversible.
Drug causes cardiogenic shock
Authors: Norra Macready
Journal: BMJ (1998)

Four hypertensive patients went into cardiogenic shock after switching from mibefradil (Posicor) to other calcium channel blockers, according to a case report. The drug was voluntarily taken off the market by the manufacturers earlier this month (13 June, p 1766).

One case resulted in death; the other three patients survived with intensive support of heart …
Physician Leadership on National Drug Policy Finds Addiction Treatment Works
Authors: C Marwick
Journal: JAMA (1998)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
154. Small Inhibitory RNA Expressed from Sleeping Beauty Transposons Can Reduce alpha1-Antitrypsin Expression
Authors: Joel Montane, Alexandre Mas, Miquel Chillon, Xavier M. Anguela, Sergio Muñoz, Efren Riu, Pedro J. Otaegui, Fatima Bosch
Journal: Molecular Therapy (2004)

Type 1 diabetes patients depend upon insulin replacement therapy. However, glycemic control is not always achieved and the resulting chronic hyperglycemia leads to microvascular, macrovascular and neurological complications. Therefore, there is a need for new treatment strategies for diabetes mellitus that would permit tight glucose regulation. Transgenic mice expressing insulin in skeletal muscle counteract type 1 diabetic alterations which indicates that muscle cells constitutively secreting low insulin levels could be used in gene therapy for diabetes. Furthermore, expression of glucokinase in skeletal muscle of transgenic mice reduced diabetic hyperglycemia without inducing hypoglycemia. However neither of these two transgenic mice showed complete reversion of the diabetic phenotype. Here, we examined the effect of co-expression of insulin and glucokinase in skeletal muscle on diabetic alterations and glycemia. Double transgenic mice expressing both insulin and glucokinase in skeletal muscle and skeletal muscle from diabetic mice electrotransferred with insulin and glucokinase genes were obtained. Blood glucose levels, skeletal muscle glucose uptake, glucose tolerance and insulin sensitivity were analyzed after streptozotozin (Stz) treatment. Double transgenic and electrotransferred mice counteracted hyperglycemia and restored fluid and food intake after treatment with Stz. In contrast, control mice presented polydipsia and polyphagia and developed severe diabetes. No hypogluycemia was detected in the Stz-treated mice expressing both insulin and glucokinase genes. In addition, these mice normalised both hepatic and skeletal muscle glucose metabolism and showed increased glucose disposal after an intraperitoneal glucose tolerance test. These results suggest that secretion of basal levels of insulin, in conjunction with increased glucose uptake by the skeletal muscle, might permit tight regulation of glycemia. Insulin and glucokinase genes cooperated by increasing glucose transport into the muscle cell and phosphorylation. Thus, this study provides evidence of a feasible non-viral gene therapy approach for type 1 diabetes involving the cooperative action of two genes, glucokinase and insulin, which leads to tight regulation of glucose homeostasis.
Abstract 5763: Dynamic Contrast-Enhanced MRI Detects Early Plaque Progression in a Rabbit Model of Atherosclerosis
Authors: William S Kerwin, Jerry Ricks, Michael Rosenfeld
Journal: Circulation (2008)

Recent studies have used dynamic contrast-enhanced (DCE) MRI to quantify the rate of uptake of gadolinium contrast agents in atherosclerotic plaque. The transfer constant K trans , that quantifies the blood supply and permeability of the plaque, shows strong association with plaque inflammation. The purpose of this study was to explore the link between K trans and plaque inflammation in a model of early atherosclerotic lesion development. Twelve NZW rabbits were placed on a 0.2% cholesterol diet and underwent balloon injury of the descending aorta. After 12 weeks, all rabbits underwent a DCE-MRI exam, after which 6 were euthanized and perfusion fixed to harvest the atherosclerotic aortas. The remaining 6 were imaged again at 24 weeks and their aortas were harvested. The DCE-MRI procedure utilized a unique, high-speed, small field-of-view imaging technique with quadruple inversion recovery blood suppression (turbo spin echo, TR=800 ms, TE=9ms, 3mm slice thickness, 0.5mm in-plane resolution). This allowed us to observe enhancement of the vessel wall without contamination from enhancement of the adjacent lumen. The DCE-MRI results were analyzed to determine the average, relative K trans in the vessel wall and compared to histological assessments of the aortas. K trans was significantly higher at 6 months compared to 3 months within the same animals (p&lt;0.005) and compared to those euthanized at 3 months (p&lt;0.001). No difference was observed between the two groups at 3 months (p=0.4). Histologically, aorta cross sections at 6 months had lesions that were no thicker than those at 3 months (0.49 vs. 0.45mm, p=0.6), but complex lesion features including necrotic cores, intraplaque hemorrhage, neovessels, and deep clusters of macrophages were significantly more common at 6 months (82% vs. 18%, p&lt;0.001). The transformation of the lesions from simple to complex morphologies from 12 weeks to 24 coincided with a significant rise in K trans . We attribute this rise to the development of neovessels in response to pro-inflammatory stimuli. We conclude that K trans can be used to probe lesion characteristics and complexity in early atherosclerosis, with applications in early diagnosis and treatment monitoring. This research has received full or partial funding support from the American Heart Association, AHA Pacific/Mountain Affiliate (Alaska, Arizona, Colorado, Hawaii, Idaho, Montana, Oregon, Washington &amp; Wyoming).
Sexual practices among patients with borderline personality disorder
Authors: George S. Zubenko, Anselm W. George, Paul H. Soloff, Patricia Schulz
Journal: American Journal of Psychiatry (1987)

The authors found that 12 (57%) of 21 consecutive male patients with borderline personality disorder who presented for psychiatric treatment at two distant geographic sites were homosexual. They then obtained the sexual histories of 80 patients who met standardized criteria for borderline disorder and found that 17 (21%) of these patients were homosexual, four (5%) were bisexual, and nine (11%) had diagnoses of paraphilias. Ten (53%) of the 19 men with borderline disorder were homosexual, compared with seven (11%) of the 61 women. Homosexuality was 10 times more common among the men and six times more common among the women with borderline personality disorder than in the general population or in a depressed control group.
Abstract 11627: Coenzyme Q10 Does Not Reduce Muscle Pain in Patients With Confirmed Statin Myalgia
Authors: Beth Taylor, Lindsay Lorson, C. Michael White, Paul D Thompson
Journal: Circulation (2014)

Background: Coenzyme Q10 (CoQ10) supplementation is the most popular therapy for statin myalgia despite limited evidence for its efficacy. We examined the effect of CoQ10 on simvastatin (SIMVA) -associated muscle pain, and strength and aerobic performance in patients with confirmed statin myalgia. Methods: Statin myalgia was confirmed in 120 patients with prior statin complaints using an 8-week randomized, double-blind crossover lead-in trial of SIMVA 20 mg/d and placebo. Forty one subjects developed muscle pain with SIMVA but not with placebo and were randomized to SIMVA 20 mg/d combined with CoQ10 (600 mg/d ubiquinol) or placebo for 8 weeks. Of the 41 subjects, 24 then crossed over to the alternative treatment (CoQ10 or placebo). Muscle pain (Brief Pain Inventory [BPI]), time to pain onset, isometric and isokinetic arm and leg muscle strength, and maximal oxygen uptake, (VO2max) were measured before and after each treatment. Results: CoQ10 blood levels increased from 1.3±0.4 to 5.2±2.3 mcg/mL with SIMVA...