THE VITAMIN C REQUIREMENT IN RHEUMATOID ARTHRITIS
Authors: Marshall G. Hall, Robert C. Darling, F. H. L. Taylor
Journal: Annals of Internal Medicine (1939)

Article1 September 1939THE VITAMIN C REQUIREMENT IN RHEUMATOID ARTHRITISMARSHALL G. HALL, M.D., ROBERT C. DARLING, M.D., F. H. L. TAYLOR, PH.D.MARSHALL G. HALL, M.D., ROBERT C. DARLING, M.D., F. H. L. TAYLOR, PH.D.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-13-3-415 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptIn normal healthy individuals the blood serum or plasma level and the urinary excretion of vitamin C are dependent largely upon the dietary intake of the vitamin.1, 2, 3, 4 It has been shown by van Eckelen5 and Heinemann6 that normal adults have a daily requirement of 60 mg. of the vitamin.The presence of infection is known to increase the requirements for vitamin C.7In patients suffering with various forms of infection the level of vitamin C in the blood plasma or serum may be reduced to the level found in patients with scurvy.7Under these circumstances the amount...Bibliography1. ABTFARMEREPSTEIN AFCJIM: Normal cevitamic (ascorbic acid) determinations in blood plasma and their relationship to capillary resistance, Jr. Pediat., 1936, viii, 1. 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RINEHARTGREENBERGBAKER JFLDF: Reduced ascorbic acid content of blood plasma in rheumatoid arthritis, Proc. Soc. Exper. Biol. and Med., 1936, xxxv, 347. CrossrefGoogle Scholar10. RINEHARTGREENBERGCHRISTIE JFLDAU: Reduced ascorbic acid content of blood plasma in rheumatic fever, Proc. Soc. Exper. Biol. and Med., 1936, xxxv, 350. CrossrefGoogle Scholar11. FARMERABT CJAF: Determination of reduced ascorbic acid in small amounts of blood, Proc. Soc. Exper. Biol. and Med., 1936, xxxiv, 146. CrossrefGoogle Scholar12. TAYLORCHASEFAULKNER FHDJM: Estimation of reduced ascorbic acid in blood serum and plasma, Biochem. Jr., 1936, xxx, 1119. CrossrefGoogle Scholar13. WRIGHTLILIENFELD ISA: Pharmacologic and therapeutic properties of crystalline vitamin C (cevitamic acid). With special reference to its effects on the capillary fragility, Arch. Int. Med., 1936, lvii, 241. CrossrefGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Boston, Massachusetts*Received for publication June 29, 1938.From the Medical Service of the Robert B. Brigham Hospital; the Thorndike Memorial Laboratory, Second and Fourth Medical Services (Harvard) of the Boston City Hospital, and the Department of Medicine, Harvard Medical School, Boston, Massachusetts. 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