GAUCHER'S DISEASE WITH ASCITES: A CASE REPORT WITH AUTOPSY FINDINGS
Authors: A N MORRISON, M LANE
Journal: Annals of Internal Medicine (1955)

Case Reports1 June 1955GAUCHER'S DISEASE WITH ASCITES: A CASE REPORT WITH AUTOPSY FINDINGSALAN N. MORRISON, M.D., MONTAGUE LANE, M.D.ALAN N. MORRISON, M.D.Search for more papers by this author, MONTAGUE LANE, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-42-6-1321 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptSince the original description of this disease in 1882, reports of approximately 280 cases have appeared in the literature. The condition was originally considered to be a primary splenic epithelioma,1and it was Gaucher who first described the cells in the spleen characteristic of this disease. The involvement of the liver by these cells was observed by Bovaird2in 1900. The classic features of Gaucher's disease—hepatosplenomegaly, brownish pigmentation of the skin, pingueculae, bone marrow infiltration with resulting anemia, leukopenia, thrombocytopenia, osseous changes, and central nervous system manifestations in infants—are well known. Despite the frequent involvement of the liver, aberrations in...Bibliography1. Gaucher E: De l'epithelioma primitif de la rate, Thésé de Paris, 1882. Google Scholar2. Bovaird D: Primary splenomegaly—endothelial hyperplasia of the spleen; two cases in children; autopsy and morphological examination in one, Am. J. M. Sc. 120: 377, 1900. CrossrefGoogle Scholar3. ReichSeifeKessler CMBJ: Gaucher's disease; a review, and discussion of twenty cases, Medicine 30: 1, 1951. CrossrefMedlineGoogle Scholar4. Snapper I: Personal communication. Google Scholar5. Thannhauser SJ: Lipidoses; diseases of the cellular lipid metabolism, 1940, Oxford University Press, New York, p. 293. Google Scholar6. Snapper I: Medical clinics on bone diseases, 1949, Interscience Publishers, Inc., New York, p. 202. Google Scholar7. Doan CA: Hypersplenism, Bull. New York Acad. Med. 25: 625, 1949. MedlineGoogle Scholar8. Risel W: Über die grosszellige Splenomegalie (Typus Gaucher) und über das endotheliale Sarkom der Milz, Beitr. z. path. Anat. 46: 241, 1909. Google Scholar9. MelamedChester SW: Osseous form of Gaucher's disease, Arch. Int. Med. 61: 798, 1938. CrossrefGoogle Scholar10. Telium G: Die Gauscher'sche Krankheit mit der Beschreibung eines Falles der Veranderungen in der Hypophyse und im Hypothalamus Zeigte, Acta med. Scandinav. 116: 170, 1944. CrossrefGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Brooklyn, N. Y.*Received for publication June 9, 1954.From the Medical Service of Dr. E. L. Shlevin, Jewish Hospital of Brooklyn. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byAscites in infantile onset type II SialidosisCauses of death in 184 patients with type 1 Gaucher disease from the United States who were never treated with enzyme replacement therapyGaucher's disease and portal hypertensionGaucher disease of the liver: CT appearanceNeurological involvement in type 1 (adult) Gaucher's disease.Nichtentzündliche Erkrankungen des UnterhautbindegewebesLiver abnormalities in patients with Gaucher's diseaseProgressive myoclonic epilepsy due to Gaucher's disease in an adult.Esophageal varices in a 60-year-old man with Gaucher's diseaseEsophageal VaricesGaucher's Disease: Neurologic Disorder in Adult SiblingsJ. D. MILLER, M.D., ROBERT McCLUER, Ph.D., JULIAN N. KANFER, Ph.D.SpeicherkrankheitenGaucher’s DiseaseGaucher's disease with portal hypertension: Case reportThe Genetic Mechanism of Gaucher's Disease,Pathological Basis of StrokesGaucher's DiseaseObservations on a patient with Gaucher's diseaseGaucher's DiseaseGAUCHER'S DISEASE IN IDENTICAL TWINS*RICHARD I. CRONE, JAMES J. BERGIN 1 June 1955Volume 42, Issue 6Page: 1321-1329KeywordsAnemiaAscitesAutopsyBone marrowCellsCentral nervous systemLiverMedical servicesSpleen ePublished: 1 December 2008 Issue Published: 1 June 1955 PDF downloadLoading ...