tbuckley/cabot-search huggingface dataset:
Trans-Fatty Acid Levels in White Adults—Reply
Authors: Hubert W. Vesper, James L. Pirkle
Journal: JAMA (2012)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Abnormal Vascular Responses to Exercise in Patients with Aortic Stenosis
Authors: Allyn L. Mark, J. Michael Kioschos, Francois M. Abboud, Donald D. Heistad, Phillip G. Schmid
Journal: Journal of Clinical Investigation (1973)

We tested the hypothesis that the normal forearm vasoconstrictor response to leg exercise is inhibited or reversed in patients with aortic stenosis, possibly because of activation of left ventricular baroreceptors. Forearm vascular responses to supine leg exercise were measured in 10 patients with aortic stenosis and in 2 control groups of 6 patients with mitral stenosis and 5 patients without valvular heart disease.
Fatal liver failure associated with pioglitazone
Authors: Ed Farley-Hills, R Sivasankar, M Martin
Journal: BMJ (2004)

in heroin supply. 4Nearly all such infections are related to injecting drug use, and there are no alternative explanations for the decrease in notifications, which was not predicted by mathematical models of the hepatitis C epidemic in Australia. 5However, the true impact of reduced supply is unlikely to be detectable for some time.Reduction in injecting drug use, as indicated by reduced output in the needle and syringe programmes, would be consistent with reduction in such infections at the population level.We are currently exploring further impacts of the shortage on overdose, treatment, and crime.
Racism and health
Authors: K. McKenzie
Journal: BMJ (2003)

Discussion of racial discrimination in medicine has concerned mainly recruitment and career development. 1 2 This has overshadowed a growing literature showing an association between racism, morbidity and mortality.3–7 Racism may be aetiologically important in the development of illness.

Racism stems from the belief that people should be treated differently because of a few phenotypic features. Racism can manifest as individual or group acts and attitudes or institutionalised processes that lead to disparities. Racism is common: in one national survey in the United Kingdom, 25-40% of participants said they would discriminate against ethnic minorities; an estimated 282 000 UK crimes were racially motivated in 1999; and a third of people from ethnic minorities constrain their lives through fear of racism. 8 9 Disparities between ethnic minority and majority groups in housing, education, arrests, and court sentencing are believed to be due to racism, not simply to economic fources. 8 9

Cross sectional studies in the United States report associations between perceived racial discrimination and hypertension, birth weight, self related …
Amelioration of severity of myocardial injury by a nitric oxide donor in rabbits fed a cholesterol-rich diet
Authors: Shiro Hoshida, Masashi Nishida, Nobushige Yamashita, Junsuke Igarashi, Masatsugu Hori, Takenobu Kamada, Tsunehiko Kuzuya, Michihiko Tada
Journal: Journal of the American College of Cardiology (1996)
Mechanistic biomarkers in acute liver injury: Are we there yet?
Authors: Danielle Adebayo, Rajeshwar P. Mookerjee, Rajiv Jalan
Journal: Journal of Hepatology (2012)

Although the outcome of acute liver failure (ALF) has improved due to developments in the general intensive care techniques, mortality rates without transplantation in patients who fulfil poor prognostic criteria are still in excess of 80%. Besides N-acetylcysteine, there are no specific treatment options for ALF that occurs on the background of acetaminophen (APAP) toxicity. Also, strategies to limit progression of acute liver injury in patients who are progressing to ALF remain an unmet need. Further difficulties in the management of patients with ALF are the lack of biomarkers that may indicate progression of liver failure early as decision making regarding listing for transplantation in patients with ALF is challenging.
Indirect Costs of Structural Interventions—Reply
Authors: Mitchell H. Katz
Journal: JAMA (2009)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Decision Making for Incompetent Patients by Designated Proxy
Authors: Robert Steinbrook
Journal: New England Journal of Medicine (1984)

Medical decisions require both technical expertise and informed consent. They should be made jointly by physicians and patients. But when the patient is incapable of participating in decision making, what should the doctor do? This question haunts contemporary discussions of medical ethics. It grabs the headlines with cases like those of Karen Ann Quinlan and the two California physicians who were accused of murdering a comatose patient by discontinuing life-sustaining treatment. It also troubles doctors who are faced with less dramatic decisions, such as whether to admit a elemented nursing-home patient to the hospital for treatment of pneumonia.1 Joint decision . . .
Thiotepa in Carcinoma of Breast Treated by Bilateral Adrenalectomy and Oophorectomy
Authors: A. B. Miller
Journal: BMJ (1961)

estimated chemically, it was of a low order, particularly in the intermediate ranges.One may conclude that single occasional smears are not accurate enough to give a useful indication of oestrogenic activity in this group of women.Even with sensitive chemical determinations, selection of those patients most likely to benefit from endocrine ablation is apparently not possible by means of OE, OD, and OT measurements alone.The trend shown by this small series suggests that the subjects with the larger amounts of the more active oestrogens, OE and OD, relative to the less active OT, may be the ones less likely to respond to castration.However, there is much overlapping, and the ratio OE plus OD :OT would not seem to have any practical predictive value.In most cases the operations were carried out as therapeutic procedures when metastases had actually occurred, rather than as a prophylactic measure.It might be that by the time these women were considered for gonadectomy, tumours which were possibly once hormone-dependent had become autonomous.Another possibility is that tumour growth is dependent not on the absolute amounts of oestrogens secreted but on the balance between the various oestrogens, their metabolites, and other hormones (Bulbrook, Greenwood, and Hayward, 1960).It may be that where surgery is effective it succeeds by altering that balance.Summary Oestrone, oestradiol, and oestriol estimations were made pre-and post-operatively on patients with breast cancer who underwent oophorectomy or adrenalectomy, or both.No difference was found in the pre-operative oestrogen levels of patients who improved and those who did not.Clinical progress was not correlated with the decrease in oestrogens caused by operation.No connexion was evident between the histology of the primary tumour and oestrogen levels or clinical response.We are grateful to the radiotherapy department and surgical staff of University College Hospital for allowing us access to their patients, and we thank the sisters for collection of specimens.
If I had...If my wife had cancer of the breast.
Authors: H Ellis
Journal: BMJ (1978)

<h3>Abstract</h3> The entomopathogenic Fungi comprise a wide range of ecologically diverse species. This group of parasites can be found distributed among all fungal phyla and as well as among the ecologically similar but phylogenetically distinct Oomycetes or water molds, that belong to a different kingdom (Stramenopila). As a group, the entomopathogenic fungi and water molds parasitize a wide range of insect hosts from aquatic larvae in streams to adult insects of high canopy tropical forests. Their hosts are spread among 18 orders of insects, in all developmental stages such as: eggs, larvae, pupae, nymphs and adults exhibiting completely different ecologies. Such assortment of niches has resulted in these parasites evolving a considerable morphological diversity, resulting in enormous biodiversity, much of which remains unknown. Here we gather together a huge amount of records of these entomopathogens to comparing and describe both their morphologies and ecological traits. These findings highlight a wide range of adaptations that evolved following the evolutionary transition to infecting the most diverse and widespread animals on Earth, the insects.
Primary Care Physician Workforce and Medicare Beneficiaries' Health Outcomes
Authors: Chiang-Hua Chang
Journal: JAMA (2011)

Despite a widespread interest in increasing the numbers of primary care physicians to improve care and to moderate costs, the relationship of the primary care physician workforce to patient-level outcomes remains poorly understood.To measure the association between the adult primary care physician workforce and individual patient outcomes.A cross-sectional analysis of the outcomes of a 2007 20% sample of fee-for-service Medicare beneficiaries aged 65 years or older (N = 5,132,936), which used 2 measures of adult primary care physicians (general internists and family physicians) across Primary Care Service Areas (N = 6542): (1) American Medical Association (AMA) Masterfile nonfederal, office-based physicians per total population and (2) office-based primary care clinical full-time equivalents (FTEs) per Medicare beneficiary derived from Medicare claims.Annual individual-level outcomes (mortality, ambulatory care sensitive condition [ACSC] hospitalizations, and Medicare program spending), adjusted for individual patient characteristics and geographic area variables.Marked variation was observed in the primary care physician workforce across areas, but low correlation was observed between the 2 primary care workforce measures (Spearman r = 0.056; P < .001). Compared with areas with the lowest quintile of primary care physician measure using AMA Masterfile counts, beneficiaries in the highest quintile had fewer ACSC hospitalizations (74.90 vs 79.61 per 1000 beneficiaries; relative rate [RR], 0.94; 95% confidence interval [CI], 0.93-0.95), lower mortality (5.38 vs 5.47 per 100 beneficiaries; RR, 0.98; 95% CI, 0.97-0.997), and no significant difference in total Medicare spending ($8722 vs $8765 per beneficiary; RR, 1.00; 95% CI, 0.99-1.00). Beneficiaries residing in areas with the highest quintile of primary care clinician FTEs compared with those in the lowest quintile had lower mortality (5.19 vs 5.49 per 100 beneficiaries; RR, 0.95; 95% CI, 0.93-0.96), fewer ACSC hospitalizations (72.53 vs 79.48 per 1000 beneficiaries; RR, 0.91; 95% CI, 0.90-0.92), and higher overall Medicare spending ($8857 vs $8769 per beneficiary; RR, 1.01; 95% CI, 1.004-1.02).A higher level of primary care physician workforce, particularly with an FTE measure that may more accurately reflect ambulatory primary care, was generally associated with favorable patient outcomes.
The Effect of Androgens on Erythropoiesis and on the Kidney.
Authors: Walter Fried
Journal: Annals of Internal Medicine (1969)

s1 May 1969The Effect of Androgens on Erythropoiesis and on the Kidney.Walter Fried, M.D., Bernard Chomet, M.D.Walter Fried, M.D.Search for more papers by this author, Bernard Chomet, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-70-5-1083_2 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptAndrogens have been shown to increase erythropoietin production in various species of mammals, including man. Although patients with anemias responsive to testosterone often have high plasma erythropoietin levels before treatment, androgens result in further elevation of these levels and probably thereby stimulate erythropoiesis. In 1937 Selye reported that androgens caused renal hypertrophy. Since the kidneys are the main site of erythropoietin production, the effects of testosterone on the kidneys and on erythropoietin production may be related. Studies were performed to clarify this relationship.Testosterone increased the plasma erythropoietin levels of normal mice and produced several-fold higher levels in mice subsequently... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Chicago, Illinois PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 May 1969Volume 70, Issue 5Page: 1083-1083KeywordsAndrogensAnemiaBlood plasmaErythropoiesisErythropoietinKidneysTestosterone Issue Published: 1 May 1969 PDF downloadLoading ...
Management of Hepatocellular Carcinoma in Cirrhotic Patients with Portal Hypertension: Relevance of Hagen-Poiseuille's Law
Authors: Gerond Lake-Bakaar, Muneeb Ahmed, Amy Evenson, Alan Bonder, Salomao Faintuch, Vinay Sundaram
Journal: Liver Cancer (2014)

&lt;b&gt;&lt;i&gt;Background: &lt;/i&gt;&lt;/b&gt;Hepatic decompensation in cirrhosis heralds an accelerated course with poor survival. An increase in hepatic venous pressure gradient (HVPG), rather than surrogate tests of liver function, appears to be the sole predictor of decompensation after surgical resection. We propose that hepatic sinusoidal walls become less elastic as cirrhosis progresses. Decompensation signals the development of increased vessel wall rigidity. The pressure-flow characteristics then become subject to Hagen-Poiseuille's law, which applies only to rigid, cylindrical vessels. Thereafter, HVPG rises exponentially (by a factor inversely proportional to the fourth power of the net radius of functional sinusoidal vessels , 1/r&lt;sup&gt;4&lt;/sup&gt;, at any given hepatic blood flow rate. This review attempts to correlate liver stiffness, risk of decompensation and outcomes from hepatocellular carcinoma (HCC) in patients with cirrhosis. &lt;b&gt;&lt;i&gt;Summary: &lt;/i&gt;&lt;/b&gt;We compare the complexity of autoregulation in the normal elastic liver, which has a unique dual blood supply, with that in the rigid cirrhotic liver. We also review, in the context of background liver cirrhosis, the management of HCC which is in essence, a solid mass of unorganized cells that exacerbates liver stiffness. We discuss the differential effects of various therapeutic modalities such as liver transplantation, loco-regional therapy and drugs on HCC outcomes, based on their effects on HVPG. &lt;b&gt;&lt;i&gt;Key Messages: &lt;/i&gt;&lt;/b&gt;Increased hepatic artery supply, or the hepatic artery buffer response, may be the only available method for autoregulation or maintenance of hepatic blood flow in the cirrhotic liver. In HCC, loco-regional therapies, including partial resection of the cirrhotic liver, can exacerbate portal hypertension by increasing blood flow within the remnant organ. We conclude that studies of HVPG reduction as part of HCC management may be beneficial and are warranted.
A powerful molecular synergy between mutant Nucleophosmin and Flt3-ITD drives acute myeloid leukemia in mice
Authors: A Mupo, L Celani, O Dovey, J L Cooper, C Grove, R Rad, P Sportoletti, B Falini, A Bradley, G S Vassiliou
Journal: Leukemia (2013)

Acute myeloid leukemia (AML) is the commonest myeloid malignancy, yet there has been little therapeutic progress for this disease in decades, and only 25–30% of patients survive long term.1 This reflects its pathogenetic complexity and the fact that the molecular basis of its largest cytogenetic subgroup, AML with a normal karyotype (AML-NK), was obscure until recently. Recent advances in DNA sequencing have revealed that AML-NK is molecularly heterogeneous with >30 genes recurrently targeted by somatic mutations in this disease.2 What is also evident is that each individual case of AML-NK appears to harbor only a small number of coding driver mutations, often as few as three and usually no more than five.2, 3 Furthermore, it is manifest that the precise combination of driver mutations in the genome of each AML impacts on its salient features, including responsiveness to treatments and prognosis.3
Acute Glomerulonephritis with Few Urinary Abnormalities
Authors: Jay A. Cohen, Marvin F. Levitt
Journal: New England Journal of Medicine (1963)

IN acute glomerulonephritis the systemic manifestations of hypertension, edema and congestive heart failure result, in large part, from salt and water retention whereas hematuria and proteinuria are direct expressions of the inflammatory process in the glomeruli. The severity of these separate manifestations and the consequent clinical picture may differ widely in individual patients. Hematuria and proteinuria, however, are present more consistently than any other finding, and before the availability of the renal-biopsy technic, the diagnosis of acute nephritis was considered unwarranted unless hematuria was demonstrated.1 It is therefore of interest to present 2 biopsy-proved cases of acute glomerulonephritis in which . . .
A possible molecular mechanism of the action of digitalis: ouabain action on calcium binding to sites associated with a purified sodium-potassium-activated adenosine triphosphatase from kidney.
Authors: A Gervais, L K Lane, B M Anner, G E Lindenmayer, A Schwartz
Journal: Circulation Research (1977)

Calcium binding at 0 degrees C to a purified sheep kidney Na+,K+-ATPase was described by linear Scatchard plots. Binding at saturating free calcium was 65-80 nmol/mg of protein, or 30-40 mol of calcium/mol of enzyme. Aqueous emulsions of lipids extracted from Na+,K+-ATPase yielded dissociation constants and maximum calcium-binding values that were similar to those for native Na+,K+-ATPase. Phospholipase A treatment markedly reduced calcium binding. Pretreatment of native Na+,K+-ATPase with ouabain increased the dissociation constant for calcium binding from 131 +/- 7 to 192 +/- 7 muM without altering maximum calcium binding. Ouabain pretreatment did not affect calcium binding to extracted phospholipids, ouabain-insensitive ATPases, or heat denatured Na+,K+-ATPase, Na+ and K+ (5-20 mM) increased the dissociation constants for calcium, which suggests competition between the monovalent cations and calcium for the binding sites. At higher concentrations of monovalent cations, ouabain increased the apparent affinity of binding sites for calcium. Extrapolation to physiological cation concentrations revealed that the ouabain-induced increase in apparent affinity for calcium may be as much as 2- to 3-fold. These results suggest: (1) calcium binds to phospholipids associated with Na+,K+-ATPase; (2) ouabain interaction with Na+,K+-ATPase induces a perturbation that is transmitted to adjacent phospholipids, altering their affinity for calcium; and (3) at physiological concentrations of Na+ or K+, or both, ouabain interaction with Na+,K+-ATPase may lead to an increased pool of membrane-bound calcium.
Was ist Familienpsychotherapie?
Authors: Pavao Brajša
Journal: Psychotherapy and Psychosomatics (1975)

Research Articles| February 12 2010 Was ist Familienpsychotherapie? Subject Area: Psychiatry and Psychology Pavao Brajša Pavao Brajša Medizinisches Zentrum Varazdin, Dispansair fúr Neurologie und Psychiatrie, Ambulanz fúr Kinder-, Jugend- und Familienpsychiatrie Search for other works by this author on: This Site PubMed Google Scholar Psychother Psychosom (1975) 25 (1-6): 142–145. https://doi.org/10.1159/000286848 Article history Published Online: February 12 2010 Content Tools Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Facebook Twitter LinkedIn Email Tools Icon Tools Get Permissions Cite Icon Cite Search Site Citation Pavao Brajša; Was ist Familienpsychotherapie?. Psychother Psychosom 31 December 1975; 25 (1-6): 142–145. https://doi.org/10.1159/000286848 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAll JournalsPsychotherapy and Psychosomatics Search Advanced Search Article PDF first page preview Close Modal This content is only available via PDF. 1975Copyright / Drug Dosage / DisclaimerCopyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher.Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. You do not currently have access to this content.