tbuckley/cabot-search huggingface dataset:
Abstract 1676: The HSP90 inhibitor 17-AAG improves chemoresistance of cisplatin-resistant esophageal squamous cell carcinoma cell lines
Authors: Takashi Ui, Kazue Morishima, Shin Saito, Yuji Sakuma, Hirofumi Fujii, Yoshinori Hosoya, Yoshikazu Yasuda, Toshiro Niki
Journal: Cancer Research (2014)

Abstract [Background] Although cisplatin is a platinum drug that is widely used to treat esophageal squamous cell carcinoma, acquired chemoresistance develops during the course of treatment and is often the reason for treatment failure. Overcoming chemoresistance is essential for improving the outcomes of patients. Heat shock protein 90 (HSP90) is known to be overexpressed in various cancer cells, and its inhibition by small molecules, either alone or in combination, has shown promise in the treatment of solid malignancies. In the present study, we evaluated the synergistic effect of combining cisplatin with the HSP90 inhibitor, 17-N-allylamino-17-demethoxy geldanamycin (17-AAG), on two cisplatin-resistant human esophageal squamous cancer cell lines, KYSE30 and KYSE150. [Results] The results obtained demonstrated the synergistic inhibitory effects of cisplatin and 17-AAG on the growth of KYSE30 and KYSE150 cells. Cell growth and cell number were more effectively reduced by the combined treatment with cisplatin and 17-AAG than by the treatment with either cisplatin or 17-AAG alone. Western blotting revealed that the combined action of cisplatin and 17-AAG cleaved poly (ADP-ribose) polymerase (PARP) and caspase 3. Time lapse imaging revealed that the activations of caspase 3/7 preceded the cell death induced by the combined treatment of cisplatin and 17-AAG. These demonstrated that the reductions in both cell growth and cell number were mediated by apoptosis. Time-course experiments showed that reductions in X-linked inhibitor of apoptosis protein (XIAP) and phosphorylated Akt were concomitant with apoptosis. [Discussion] The results of the present study demonstrated that 17-AAG synergized with cisplatin and induced apoptosis in cisplatin-resistant esophageal squamous cell carcinoma cell lines, and also that modulation of the Akt/XIAP pathway may underlie this synergistic effect. [Conclusion] Combination therapy with cisplatin and a HSP90 inhibitor may represent a promising strategy to overcome cisplatin resistance in esophageal squamous cell carcinoma. Citation Format: Takashi Ui, Kazue Morishima, Shin Saito, Yuji Sakuma, Hirofumi Fujii, Yoshinori Hosoya, Yoshikazu Yasuda, Toshiro Niki. The HSP90 inhibitor 17-AAG improves chemoresistance of cisplatin-resistant esophageal squamous cell carcinoma cell lines. [abstract]. In: Proceedings of the 105th Annual Meeting of the American Association for Cancer Research; 2014 Apr 5-9; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2014;74(19 Suppl):Abstract nr 1676. doi:10.1158/1538-7445.AM2014-1676
Abstract 18718: The Sarcoplasmic Reticulum Calcium ATPase (SERCA) Cysteine 674 Thiol is Required for Cardiac Myocyte Hypertrophy
Authors: Robert J Morgan, Fuzhong Qin, David R Pimentel, Deborah A Siwik, Richard A Cohen, Wilson S Colucci
Journal: Circulation (2014)

Introduction: Cardiac hypertrophy is mediated in part by oxidative stress and calcium-sensitive pathways. The interaction between oxidative stress and calcium signaling is not understood. The activity of SERCA, which maintains calcium stores, is regulated via oxidative post-translational modification of the cysteine 674 (C674) thiol, with stimulation caused by reversible glutathiolation and inhibition of that mechanism by irreversible sulfonylation. Hypothesis: We used a knock-in mouse in which SERCA C674 is mutated to serine in one allele (SKI mouse), eliminating the thiol and resulting in decreased redox-sensitivity of the enzyme in order to test the hypothesis that redox regulation of SERCA C674 mediates myocardial hypertrophy in vivo and in vitro. Methods & Results: WT and SKI mice (8-10 weeks old) were subjected to ascending aortic constriction (AAC) for 3 weeks. In WT, AAC increased left ventricular (LV) total wall thickness measured by echocardiography from 1.52 ± 0.02 mm to 1.88 ± 0.06 mm (p<0.001...
Tiotropium effects on airway inflammatory events in the cat as an animal model for acute cigarette smoke-induced lung inflammation
Authors: Khalil Ansarin, Saeed Kolahian, AmirAli Shahbazfar, Tayefi-Nasrabadi Hossain, Keyhanmanesh Raana, Ghasemi Hamid, Rashidi Amirhossain, Gosens Reinoud, Hanifeh Mohsen
Journal: European Respiratory Journal (2014)

Background:  Chronic obstructive pulmonary disease is an inflammatory lung disease mainly caused by tobacco smoke inhalation.  Methods:  Fifteen healthy adult male cats were categorized into 3 groups: I) control group, II) exposed to cigarette smoke (CS), and III) exposed to CS treated with tiotropium.  Results:  Increases in clinical signs and airway responsiveness in CS cats were found compared with control animals. These airway hyper-responsiveness and clinical signs were significantly attenuated by treatment with tiotropium. The CS-induced pulmonary release of IL-6, IL-8, MCP-1, and TNF alpha was reduced with tiotropium treatment. Exposure to CS significantly increased total inflammatory cell number in BAL fluid, which was significantly attenuated by treatment with tiotropium. The numbers of macrophages, eosinophils and neutrophils and lymphocytes were all increased after exposure to CS. Tiotropium significantly reduced the number of all these cells. Perivascular, peribronchiolar infiltration of inflammatory cells and Reid index increased in the CS group. Enhanced lipid peroxidation with concomitant reduction of antioxidants status was observed in the CS group. Tiotropium significantly reduced the serum, lung lavage, lung and tracheal tissue lipid peroxides to near control levels. Tiotropium also decreased lung and tracheal protein leakage, and prevented the reduction of total antioxidant status in serum, lung lavage, lung and tracheal tissue of the CS group.  Conclusion:  Cigarette smoke increases airway responsiveness and inflammation in a cat model of CS induced lung inflammation, which can effectively be reduced by treatment with tiotropium.
Generic Abilify Gets FDA Approval
Authors: Rita Rubin
Journal: JAMA (2015)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Abstract 1: A Randomised Placebo Controlled Trial of Adrenaline in Cardiac Arrest - the PACA Trial
Authors: Ian Jacobs, Judith Finn, George Jelinek, Harry Oxer, Peter Thompson
Journal: Circulation (2010)

Background: Adrenaline (Epinephrine) remains the primary pharmacological agent in cardiac arrest. Despite a total absence of any experimental trials to establish efficacy, adrenaline is considered ...
THE PLEURAL AND PULMONARY COMPLICATIONS OF CARCINOMA OF THE ESOPHAGUS
Authors: Chester S. Keefer
Journal: Annals of Internal Medicine (1934)

Article1 July 1934THE PLEURAL AND PULMONARY COMPLICATIONS OF CARCINOMA OF THE ESOPHAGUSCHESTER S. KEEFER, M.D., F.A.C.P.CHESTER S. KEEFER, M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-8-1-72 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptINTRODUCTIONOne of the ways carcinoma of the esophagus may disguise itself is in the form of a chronic pleural or pulmonary infection. This usually is the result of a perforation of the esophagus into the trachea, bronchi, mediastinum, lung or pleura. In some cases, food or fluid is aspirated into the air passages due to the obstruction of the esophagus, or a necrotic lymph node which is the site of metastases may perforate into both the lung and esophagus producing a fistula. In other cases, the trachea or bronchi may be obstructed due to the invasion of the tumor...Bibliography1. DAVIDSONMILLS PBES: Fistulae between esophagus and respiratory tract, Med. Clin. N. Am., 1923, vii, 999-1017. Google Scholar2. CALDERARA A: Beiträge zur Kenntnis der Kankroide, Virchow's Arch. f. path. Anat., 1910, cc, 181-192. CrossrefGoogle Scholar3. ZENKERZIEMSSEN VV: Handbuch, II Aufl., Bd. VII; Quoted by MOHR, L., and STAEHELIN, R.: Handbuch der inneren Medizin, Julius Springer, 1918, iii (part 1), 253. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Boston, Massachusetts*Received for publication April 20, 1934.From the Thorndike Memorial Laboratory, Second and Fourth Medical Services (Harvard), Boston City Hospital and the Department of Medicine, Harvard Medical School, Boston, Mass. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited bySekundäre maligne Tumoren der Bronchien und LungenOne hundred consecutive cases of dysphagia: Some problems in diagnosisSURGICAL ASPECTS OP CARCINOMA OF THE ESOPHAGUSTREATMENT OF LUNG ABSCESS 1 July 1934Volume 8, Issue 1Page: 72-81KeywordsBronchiEsophagusFoodHospital medicineLungsLymph nodesMedical servicesPulmonary diseasesResearch laboratoriesTrachea ePublished: 1 December 2008 Issue Published: 1 July 1934 PDF downloadLoading ...
Low-dose isotretinoin in acne vulgaris: a critical review
Authors: K. Sardana, V.K. Garg
Journal: British Journal of Dermatology (2011)

Journal Article Low‐dose isotretinoin in acne vulgaris: a critical review Get access K. Sardana, K. Sardana Maulana Azad Medical College and Lok Nayak Hospital, New Delhi, India. E‐mail: kabirijdvl@gmail.com Search for other works by this author on: Oxford Academic Google Scholar V.K. Garg V.K. Garg Maulana Azad Medical College and Lok Nayak Hospital, New Delhi, India. E‐mail: kabirijdvl@gmail.com Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 165, Issue 3, 1 September 2011, Pages 698–700, https://doi.org/10.1111/j.1365-2133.2011.10440.x Published: 01 September 2011
Fractional flow reserve (FFR) for the appropriateness of percutaneous transluminal coronary angioplasty (PTCA) in patients with a coronary stenosis but without proof of ischemia : two-year follow-up of the prospective randomized DEFER study
Authors: Gjw Jan Willem Bech, de B Bruyne, Nhj Nico Pijls, de E Muinck, Jca Hoorntje, J Escaned, PR Stella, E Boersma, J Jozef Bartunek, Jacques J Koolen, W Wijns
Journal: Journal of the American College of Cardiology (2001)
Gewebezüchtung. Handbuch der Biologie der Gewebezellen in Vitro.
Authors: Albert Fischer
Journal: JAMA (1928)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Review of the 94th Annual Meeting of the British Association of Dermatologists, Glasgow 2014
Authors: R.M. Porter, S.M.C. George
Journal: British Journal of Dermatology (2015)

This is a review of the 94th Annual Meeting of the British Association of Dermatologists, held in Glasgow from 1 to 3 July 2014. The conference covered some of the latest developments in the treatment of atopic dermatitis, psoriasis and cancer, a follow-up on the methylisothiazolinone contact allergy epidemic, advances in genetically inherited disorders and somatic mutations underlying birth marks. In addition, there was an international perspective on vitiligo, leprosy and HIV, and a session discussing the regulatory process behind pharmaceutical development.
Battered parents: a new syndrome
Authors: H T Harbin, D J Madden
Journal: American Journal of Psychiatry (1979)

The authors identify a new syndrome of family violence--parent battering. Relevant dynamics include individual characteristics of the parent batterer, distortions in the generational authority hierarchy, the role of secrets and denial, and cultural influences. The authors conclude, on the basis of their clinical work with these families, that this subtype of family violence is distinct from child and spouse abuse.
Abstract 12859: Increased Physical Activity Prevents the Progress of Left Ventricular Hypertrophy via Reducing Advanced Glycation End-Products in Patients With Hypertension
Authors: Aoyama Akihiro, Takashi Masuda, Ogura Misao, Shimizu Ryosuke, Kato Michitaka, Kamekawa Daisuke, Kamada Yumi, Tanaka Shinya, Kamiya Kentaro, Hamazaki Nobuaki, Maekawa Emi, Tojo Y Minako, Ako Junya
Journal: Circulation (2014)

Background: Elevated oxidative stress or insulin resistance has been shown to promote the production of advanced glycation end-products (AGEs) in patients with hypertension (HT). AGEs are known to enhance left ventricular hypertrophy (LVH) via the activation of nuclear factor-kappa B in myocardium. Although increased physical activity (PA) reduces elevated oxidative stress or insulin resistance, it is unclear whether increased PA inhibits the AGEs production and prevents the progress of LVH in HT patients. The aim of this study was to investigate the influence of increased PA on AGEs and LVH in them. Methods: Seventy five HT patients aged 70 ± 8 years were prospectively followed up for a year, whose blood pressure was controlled under 140/90mmHg. We assessed daily steps as a parameter of PA using an accelerometer. We also measured serum malondialdehyde-modified LDL-cholesterol (MDA-LDL), plasma pentosidine, homeostasis model assessment ratio (HOMA-R) and left ventricular mass index (LVMI) as parameters of...
Abstract P109: The Cross-sectional and Longitudinal Association of Dispositional Optimism with Sleep Duration and Quality: Findings form the Coronary Artery Risk Development in Young Adults (CARDIA) Study
Authors: Rosalba Hernandez, Thanh-Huyen T Vu, Kiarri N Kershaw, Mercedes Carnethon, Kristen L Knutson, Laura Colangelo, Kiang Liu
Journal: Circulation (2014)

Background: Sleep disturbance is associated with multiple adverse cardiovascular-related health outcomes. Little is known about the relationship between psychological well-being, an independent modifiable risk factor for cardiovascular disease, and sleep disruptions. This study examines cross-sectional and longitudinal associations of optimism with sleep duration and quality. Methods: Data were collected from 3,549 Black and White adults aged 33-45 years who participated in the Coronary Artery Risk Development in Young Adults (CARDIA) study during follow-up years 15 (2000-2001) and 20 (2005-2006). Optimism was assessed in 2000-2001 using the Life-Orientation Test—Revised, with possible scores ranging from 6 (least optimistic) to 30 (most optimistic). Single-item questions on sleep quality and duration in the past month were assessed during 2000-2001 and 2005-2006. Cross-sectional analyses considered optimism and sleep measures at follow-up year 15. Longitudinal analyses considered 5-year incidence of poor sleep quality (fairly/very bad) and duration (short/long sleep) in 2005-2006 by optimism in 2000-2001 (participants with poor sleep quality and duration in 2000-2001 were excluded). Results: Among 3,549 participants (56% female, 46% Black) with complete data on optimism in 2000-2001, 15.9% reported fairly/very bad sleep quality. Sleep duration was distributed as follows: short-sleep (47.9%), sufficient sleep (31.6%), and long-sleep (20.5%). In unadjusted and fully adjusted models, a 1-unit higher optimism score was cross-sectionally associated with 11% lower odds of having fairly/very bad sleep quality and 3-5% lower odds of having short-sleep duration (Table 1). Cross-sectional associations were attenuated after adjustment for depressive symptoms (not shown). Incidence of poor sleep quality in 2005-2006 was 7% lower with each unit higher optimism score, after full adjustment. Conclusion: Optimism is associated with lower incidence of poor self-reported sleep quality over a 5-year period.
Comparison of Autologous Bone Marrow Transplantation and Intensive Chemotherapy as Postremission Therapy in Adult Acute Myeloid Leukemia
Authors: Jean-Luc Harousseau, Jean-Yves Cahn, Bernard Pignon, Francis Witz, Noël Milpied, Martine Delain, Bruno Lioure, Thierry Lamy, Bernard Desablens, François Guilhot, Denis Caillot, Jean-François Abgrall, Sylvie Francois, Jean Briere, Denis Guyotat, Philippe Casassus, Bruno Audhuy, Zéra Tellier, Patrick Hurteloup, Patrick Herve
Journal: Blood (1997)
Abstract 312: "Stand Clear" Belongs to the Past: A Solution for Safe Hands-on Defibrillation
Authors: Jakob E Thomsen, Graham W Petley, Bo Løfgren, Charles D Deakin
Journal: Circulation (2014)

Introduction: Interruptions to chest compressions during defibrillation reduce the chances of subsequent ROSC and successful defibrillation. Safe hands-on defibrillation (HOD) will allow uninterrupted chest compression during defibrillation and may improve resuscitation success. We tested the safety of rescuer contact with the patient (at the waist) whilst additionally wearing electrical insulating gloves during clinical defibrillation; a worst case scenario. Materials and Method: Leakage current flowing from the patient to the ‘rescuer’ during defibrillation of patients undergoing elective defibrillation was measured. The ‘rescuer’ remained in contact with the patient during defibrillation, wearing Class 1 electrical insulating gloves while simulating an inadvertent contact with the patient, through an additional wired contact between rescuer’s waist and patient. The results were compared with an international safety threshold of 1 mA. Results: Data from 67 shocks of variable biphasic energy from a total of 50 patients was recorded. The median leakage current from all defibrillations was 30 μA, (range: 7 - 164). Of the 34 of the shocks delivered at 360J the median leakage current was 62 μA (range: 13 - 164), all below the safety threshold of 1 mA. Conclusion: This study demonstrates that leakage current through the rescuer is within a safe threshold to allow hands-on defibrillation when using electrically insulated gloves and in the presence of an additional point of contact with the patient
Ischemia- and cytokine-induced mobilization of bone marrow-derived endothelial progenitor cells for neovascularization
Authors: Tomono Takahashi, Christoph Kalka, Haruchika Masuda, Donghui Chen, Marcy Silver, Marianne Kearney, Meredith Magner, Jeffrey M. Isner, Takayuki Asahara
Journal: Nature Medicine (1999)
Abstract 703: Highly selective HSV virotherapy for glioblastoma
Authors: Aofei Li, Marco Marzulli, Lucia Mazzacurati, Hiroaki Uchida, Justus Cohen, Joseph Glorioso, Paola Grandi
Journal: Cancer Research (2014)

Abstract Glioblastoma Multiforme (GBM) is an aggressive brain cancer for which there is no effective treatment. Oncolytic HSV vectors (oHSV) are attenuated lytic viruses that have shown promise in the treatment of human GBM models in animals. Although proven safe for treatment of GBM in patients, oHSVs efficacy has been limited, a consequence of poor intra-tumoral virus replication and spread. To counter these limitations, we have developed oHSVs whose selective replication in GBM cells does not rely on defective genes. This was accomplished by (i) full retargeting of oHSV to utilize the epidermal growth factor receptor (EGFR) for infection of human GBM tumor cells and (ii) further vector engineering to modify the essential HSV immediate early gene (ICP4) for sensitivity to repression by the microRNA mir-124. Mir-124 is highly expressed in neurons but virtually absent in GBM and highly conserved among different species. The mir-124-regulated vector was unable to replicate in nude mice following intracranial inoculation supporting vector safety and was shown to be effective in the treatment of human GBM in nude mice. To enhance vector intra-tumor vector spread, our EGFR retargeted-mir-124 controlled vector was further modified by vector arming with the matrix metalloproteinase gene encoding MMP9. MMP9 degrades collagen type IV, a major component of the extracellular matrix (ECM) and basement membranes of glioblastomas but absent in normal brain tissue. Studies are ongoing to determine whether MMP9 expression enhances vector spread in GBM neurospheres and as a therapeutic agent for enhanced treatment of human GBM in animals Citation Format: Aofei Li, Marco Marzulli, Lucia Mazzacurati, Hiroaki Uchida, Justus Cohen, Joseph Glorioso, Paola Grandi. Highly selective HSV virotherapy for glioblastoma. [abstract]. In: Proceedings of the 105th Annual Meeting of the American Association for Cancer Research; 2014 Apr 5-9; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2014;74(19 Suppl):Abstract nr 703. doi:10.1158/1538-7445.AM2014-703
Quality of life after balloon angioplasty or stenting for acute myocardial infarction
Authors: Stéphane Rinfret, Cindy L Grines, Roberta S Cosgrove, Kalon K.L Ho, David A Cox, Bruce R Brodie, Marie-Claude Morice, Gregg W Stone, David J Cohen
Journal: Journal of the American College of Cardiology (2001)