Sedentary Time and Risk for Mortality
Authors: Seigo Urushidani, Akira Kuriyama
Journal: Annals of Internal Medicine (2015)

Letters16 June 2015Sedentary Time and Risk for MortalitySeigo Urushidani, MD and Akira Kuriyama, MD, MPHSeigo Urushidani, MDFrom Kurashiki Central Hospital, Kurashiki, Japan.Search for more papers by this author and Akira Kuriyama, MD, MPHFrom Kurashiki Central Hospital, Kurashiki, Japan.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/L15-0180 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:Biswas and colleagues (1) did a meta-analysis of observational studies to examine the association between sedentary time and various health outcomes. Their analysis suggested that sedentary time was associated with an increased risk for all-cause mortality but was substantially heterogeneous (I2 = 94.96%). We wonder whether further sensitivity analyses are needed to elucidate the cause of this heterogeneity.First, sample sizes varied across studies, ranging from 217 to 240 819. A forest plot suggested that 5 of the 7 studies with fewer than 10 000 participants presented more exaggerated point estimates of hazard ratios than the remaining 8 studies. In ...References1. Biswas A, Oh PI, Faulkner GE, Bajaj RR, Silver MA, Mitchell MS, et al. Sedentary time and its association with risk for disease incidence, mortality, and hospitalization in adults: a systematic review and meta-analysis. Ann Intern Med. 2015;162:123-32. [PMID: 25599350] doi:10.7326/M14-1651 LinkGoogle Scholar2. Pereira TV, Horwitz RI, Ioannidis JP. Empirical evaluation of very large treatment effects of medical interventions. JAMA. 2012;308:1676-84. [PMID: 23093165] doi:10.1001/jama.2012.13444 CrossrefMedlineGoogle Scholar3. Seguin R, Buchner DM, Liu J, Allison M, Manini T, Wang CY, et al. Sedentary behavior and mortality in older women: the Women's Health Initiative. Am J Prev Med. 2014;46:122-35. [PMID: 24439345] doi:10.1016/j.amepre.2013.10.021 CrossrefMedlineGoogle Scholar4. Matthews CE, George SM, Moore SC, Bowles HR, Blair A, Park Y, et al. Amount of time spent in sedentary behaviors and cause-specific mortality in US adults. Am J Clin Nutr. 2012;95:437-45. [PMID: 22218159] doi:10.3945/ajcn.111.019620 CrossrefMedlineGoogle Scholar5. van der Ploeg HP, Chey T, Korda RJ, Banks E, Bauman A. Sitting time and all-cause mortality risk in 222 497 Australian adults. Arch Intern Med. 2012;172:494-500. [PMID: 22450936] doi:10.1001/archinternmed.2011.2174 CrossrefMedlineGoogle Scholar Author, Article, and Disclosure InformationAffiliations: From Kurashiki Central Hospital, Kurashiki, Japan.Disclosures: Authors have disclosed no conflicts of interest. Forms can be viewed at www.acponline.org/authors/icmje/ConflictOf InterestForms.do?msNum=L15-0180. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoSedentary Time and Its Association With Risk for Disease Incidence, Mortality, and Hospitalization in Adults Aviroop Biswas , Paul I. Oh , Guy E. Faulkner , Ravi R. Bajaj , Michael A. Silver , Marc S. Mitchell , and David A. Alter Sedentary Time and Its Association With Risk for Disease Incidence, Mortality, and Hospitalization in Adults Aviroop Biswas , Paul I. Oh , Guy E. Faulkner , Ravi R. Bajaj , Michael A. Silver , Marc S. Mitchell , and David A. Alter Sedentary Time and Risk for Mortality Aviroop Biswas and David A. Alter Sedentary Time and Risk for Mortality Aviroop Biswas and David A. Alter Metrics 16 June 2015Volume 162, Issue 12Page: 875KeywordsClinical trialsConflicts of interestDisclosureForecastingInformation retrievalObservational studiesPopulation statisticsSystematic reviews ePublished: 16 June 2015 Issue Published: 16 June 2015 CopyrightCopyright © 2015 by American College of Physicians. All Rights Reserved.PDF DownloadLoading ...