tbuckley/cabot-search huggingface dataset:
First use of an untethered, vented electric left ventricular assist device for long-term support.
Authors: O H Frazier
Journal: Circulation (1994)

This report describes the first long-term (505-day) application of the vented electric (VE) HeartMate left ventricular assist device (LVAD) (Thermo Cardiosystems, Inc). The device consists of an abdominally placed, battery-powered titanium blood pump that, in contrast to earlier pneumatically powered systems, allows patients untethered freedom of movement. The batteries last 5 to 8 hours and can be changed on a rotating basis indefinitely. The patient, a 33-year-old man (90 kg, blood type O) with idiopathic cardiomyopathy, experienced end-organ heart failure (New York Heart Association [NYHA] class IV) while he was awaiting heart transplantation. When his hemodynamic criteria met those outlined in the protocol, we implanted the VE-LVAD as a bridge to transplantation. The patient was supported by the device for more than 16 months. His cardiac status returned to NYHA class I, and he was eventually allowed to take day trips outside the hospital as he awaited transplantation. The VE-LVAD enabled the patient to participate in activities such as eating in restaurants, going to movies, and practicing basketball shots. Unfortunately, the patient died suddenly due to a neurological thromboembolic event that occurred on day 503 of VE-LVAD support. The VE-LVAD improved native left ventricular function by chronic unloading, and ventricular remodeling resulted in a more normal configuration anatomically, physiologically, and ultimately, histologically and pathologically.
Neuropsychological deficits and morphological MRI brain scan abnormalities in apparently healthy non-encephalopathic patients with cirrhosis
Authors: J.W. Moore, A.A. Dunk, J.R. Crawford, H. Deans, J.A.O. Besson, G. De Lacey, T.S. Sinclair, N.A.G. Mowat, P.W. Brunt
Journal: Journal of Hepatology (1989)
Efficacy of Intranasal Corticosteroids for Acute Sinusitis
Authors: Peter R. Starke, Badrul A. Chowdhury
Journal: JAMA (2002)

To the Editor: Dr Dolor and colleagues 1 concluded that intranasal corticosteroids are efficacious in the treatment of acute rhinosinusitis. We believe, however, that the design of their trial significantly limits the conclusions that can be drawn from it. We believe the trial design was more like that of a large simple trial rather than a well-controlled trial. The primary efficacy variable was “time to clinical success,” based solely on telephone reports of whether patients were feeling better. There were no objective measures of compliance or improvement. Direct patient symptom assessments were used as secondary end points, and interestingly, failed to show significant differences between fluticasone and placebo. The entry criteria were also problematic. Since duration of symptoms was not measured at study entry, the diagnosis of acute sinusitis could not be adequately established. 2,3 The entry criterion allowing for mucosal thickening on radiographs is a poor indicator of sinusitis, particularly in the setting of chronic sinus disease and other possible comorbid conditions, such as rhinitis or upper respiratory infections, in which as many as 87% of patients have such radiographic abnormalities. 4 It is likely that the observed benefits were selected to the effects of intranasal corticosteroids on rhinitis symptoms, such as congestion, and not on relief of specific sinus-related symptoms. Intranasal corticosteroids are effective and approved for treatment of symptoms associated with both allergic and perennial nonallergic rhinitis, which often accompany chronic sinus disease. Recently, even the use of antibiotics for uncomplicated sinusitis has been questioned. 5 Adding other therapies of unproven benefit to illnesses that may spontaneously improve only confounds and complicates medical practice. We do not believe that there are sufficient data that intranasal corticosteroids have a substantive role in the treatment of rhinosinusitis. Furthermore, we do not believe that there is a safety database to establish that the use of intranasal corticosteroids in the presence of acute bacterial sinusitis is sufficiently safe. We are concerned that the risk vs benefit ratio for the use of intranasal corticosteroids in sinusitis needs further evaluation prior to recommendations for such use.
MASSIVE DYSTROPHIC CALCIFICATION OF THE MYOCARDIUM
Authors: I I LASKY
Journal: Annals of Internal Medicine (1954)

Case Reports1 March 1954MASSIVE DYSTROPHIC CALCIFICATION OF THE MYOCARDIUMIRVING I. LASKY, M.D.IRVING I. LASKY, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-40-3-626 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptMassive calcification in myocardial infarcts is relatively uncommon. Although there are not more than 21 undoubted cases in the medical literature to date, the condition occurs in a well defined group of patients with a characteristic clinical picture and may be demonstrated by standard radiologic technics. The diagnosis is of some prognostic import since these patients, like others with coronary heart disease, are prone to sudden death.Dystrophic calcification is the term applied to the laying down of calcium in dead, degenerated or devitalized tissue, as in infarcts. This constitutes the most common type of pathologic calcification and is not...Bibliography1. Duncan GG: Diseases of metabolism, 3d Ed., 1947, W. B. Saunders Co., Philadelphia. Google Scholar2. GoveArons IW: Calcification of the myocardium; pathological study of 13 cases, Arch. Path. 48: 1 (July) 1949. Google Scholar3. Simmonds M: Über der Nachweis von Verkalkungen am Herzen durch das Röntgenverfahren, Fortschr. a. d. Geb. d. Röntgenstrahlen 12: 371, 1908. Google Scholar4. BreanMarksSosmanSchlesinger HPJHMCMJ: Massive calcification in infarcted myocardium, Radiology 54: 33, 1950. CrossrefMedlineGoogle Scholar5. BrennerWachner FG: Über einen ungewöhnlichen Sitz eines Herzaneurysmas und seine Rontgendiagnostik, Fortschr. a. d. Geb. d. Röntgenstrahlen 54: 243 (Sept.) 1936. Google Scholar6. BrownEvans CEWD: Primary calcification of the myocardium, Am. Heart J. 19: 106, 1940. CrossrefGoogle Scholar7. Sossman MC: The technique for locating and identifying pericardial and intracardiac calcifications, Am. J. Roentgenol. 150: 461 (Oct.) 1943. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Beverly Hills, California*Received for publication July 23, 1953. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byRapid Onset Development of Myocardial Calcifications in the Setting of Renal Failure and SepsisIncidental Myocardial Infarct on Conventional Nongated CT: A Review of the Spectrum of Findings With Gated CT and Cardiac MRI CorrelationA Massive Calcified Left Ventricular Aneurysm with Normal Coronary Arteries and Without Myocardial InfarctionMyocardial fibre calcification.Massive Calcification of the MyocardiumIntrakardiale VerkalkungenCardiovascular SystemMassive calcification of the myocardiumMyokarditis und weitere Myokardiopathien 1 March 1954Volume 40, Issue 3Page: 626-631KeywordsCalciumCoronary heart diseaseMyocardial infarctionMyocardium ePublished: 1 December 2008 Issue Published: 1 March 1954 PDF downloadLoading ...
Contraindications to use of metformin
Authors: A. T Elder
Journal: BMJ (2003)

Medical staff need to be aware of major incident planningEditor-Last month the BMA warned that too few people in the United Kingdom know how to respond to a terrorist attack. 1 Its concerns about too few senior officials being aware of plans and recommendations to improve preparedness are sensible, but we believe that not enough medical staff are aware of their role in the event of a terrorist attack.We recently carried out a survey in the largest acute NHS trust of the south west of England to assess medical staff's knowledge about the local major incident plan.We sent questionnaires to the 107 doctors in North Bristol NHS Trust with a potential role in the mobile medical team if they were on duty during a major incident.Seventy seven doctors replied (72%).Sixty nine were aware of the existence of the local major incident plan, but only 26 had read part or all of it.Only 11 of the responding doctors were aware of their potential role in the mobile medical team.Of these 11 doctors, only three thought themselves adequately trained for this position, and all three had been trained as medical incident officers.Last year's National Audit Office report highlighted deficiencies in NHS plans to deal with major incidents in England. 2 It recommended upgrading training arrangements.Five months later some doctors are still unaware of their roles in the event of a terrorist attack.As a trust we are currently considering several measures to improve on our results.We suspect, however, that our findings are not unique and encourage other acute trusts to look closely at their staff's knowledge and training and act accordingly.
The Dietetic Management of the Diabetic in the Doctor's Office
Authors: W. H. Olmsted
Journal: Annals of Internal Medicine (1928)

Article1 October 1928The Dietetic Management of the Diabetic in the Doctor's OfficeW. H. OLMSTEDW. H. OLMSTEDSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-2-4-325 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptIt hardly seems necessary to point out that the discovery of insulin has not changed the necessity for measuring the diet of the diabetic individual. Insulin has made diabetic diets more generous in the amount of carbohydrate used. This is most graphically shown by the improvement recorded in diabetic children. With insulin treatment and the resulting increase of carbohydrate intake normal growth and development are usually possible,―quite the opposite picture from the diabetic child of preinsulin days. Today there are two reasons why we must insist that the diabetic measure his food: First; because if insulin and diet are not... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: *Read before the American College of Physicians, March 8, 1928, New Orleans, La. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 October 1928Volume 2, Issue 4Page: 325-333KeywordsCarbohydratesChildrenDietFoodInsulin ePublished: 1 December 2008 Issue Published: 1 October 1928 PDF downloadLoading ...
833. Metabolically Stabilized Non-Viral Gene Delivery Systems
Authors: Dijie Liu, Molly E. Martin, Changpo Chen, Kevin G. Rice
Journal: Molecular Therapy (2004)

Peptide-based gene delivery systems are composed of synthetic (20 amino acid) peptides derivatized with a targeting oligosaccharide or a polyethylene glycol chain (PEG) 1,2. Ad-mixtures of the glycopeptide and PEG-peptide conjugates were used to form DNA condensates that were stabilized by glutaraldehyde cross-linking through formation of a di-Schiffs base. The degree of metabolic stability is directly related to the degree of glutaraldehyde crosslinking, with metabolic half-lives in mouse liver ranging from 2 hours to 3 days 3.
Abstract 11415: NGAL is Independently Associated with Cardiovascular Disease and All-Cause Mortality in Community-Dwelling Older Adults: The Rancho Bernardo Study
Authors: Lori B Daniels, Paul Clopton, Gail A Laughlin, Joachim H Ix, Alan S Maisel, Elizabeth Barrett-Connor
Journal: Circulation (2011)

Lori B. Daniels, 2011 Finalist and Presenting Author
Crisis in Sudan
Authors: Joan Stephenson
Journal: JAMA (2004)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Updating the Academic Playbook
Authors: Elena Fuentes-Afflick
Journal: JAMA Pediatrics (2015)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Pediatrics HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Pediatrics journal
Identification of novel and known <i>KRT5</i> and <i>KRT14</i> mutations in 53 patients with epidermolysis bullosa simplex: correlation between genotype and phenotype
Authors: M.J. Arin, G. Grimberg, H. Schumann, H. De Almeida Jr, Y.-R. Chang, G. Tadini, J. Kohlhase, T. Krieg, L. Bruckner-Tuderman, C. Has
Journal: British Journal of Dermatology (2010)

Journal Article Identification of novel and known KRT5 and KRT14 mutations in 53 patients with epidermolysis bullosa simplex: correlation between genotype and phenotype Get access M.J. Arin, M.J. Arin Department of Dermatology, University of Cologne, Kerpener Strasse 62, 50924 Cologne, Germany Meral J. Arin. E‐mail: meral.arin@uk‐koeln.de Search for other works by this author on: Oxford Academic Google Scholar G. Grimberg, G. Grimberg Department of Dermatology, University of Cologne, Kerpener Strasse 62, 50924 Cologne, Germany Search for other works by this author on: Oxford Academic Google Scholar H. Schumann, H. Schumann Department of Dermatology, University of Freiburg, Freiburg, Germany Search for other works by this author on: Oxford Academic Google Scholar H. De Almeida Jr, H. De Almeida Jr Department of Dermatology, University of Pelotas, Pelotas, Brazil Search for other works by this author on: Oxford Academic Google Scholar Y.‐R. Chang, Y.‐R. Chang Department of Dermatology, University of Freiburg, Freiburg, Germany Search for other works by this author on: Oxford Academic Google Scholar G. Tadini, G. Tadini Department of Dermatology, University of Milano, Germany Search for other works by this author on: Oxford Academic Google Scholar J. Kohlhase, J. Kohlhase Center for Human Genetics, Freiburg, Germany Search for other works by this author on: Oxford Academic Google Scholar T. Krieg, T. Krieg Department of Dermatology, University of Cologne, Kerpener Strasse 62, 50924 Cologne, Germany Search for other works by this author on: Oxford Academic Google Scholar L. Bruckner‐Tuderman, L. Bruckner‐Tuderman Department of Dermatology, University of Freiburg, Freiburg, GermanyFreiburg Institute for Advanced Studies, University of Freiburg, Freiburg, Germany Search for other works by this author on: Oxford Academic Google Scholar C. Has C. Has Department of Dermatology, University of Freiburg, Freiburg, Germany Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 162, Issue 6, 1 June 2010, Pages 1365–1369, https://doi.org/10.1111/j.1365-2133.2010.09657.x Published: 01 June 2010
MASSIVE DOSES OF VITAMIN D IN THE TREATMENT OF PROLIFERATIVE ARTHRITIS
Authors: Bernard L. Wyatt, Robert Alan Hicks, H. E. Thompson
Journal: Annals of Internal Medicine (1936)

Article1 October 1936MASSIVE DOSES OF VITAMIN D IN THE TREATMENT OF PROLIFERATIVE ARTHRITISBERNARD L. WYATT, M.D., F.A.C.P., ROBERT ALAN HICKS, M.D., H. E. THOMPSON, M.D.BERNARD L. WYATT, M.D., F.A.C.P.Search for more papers by this author, ROBERT ALAN HICKS, M.D.Search for more papers by this author, H. E. THOMPSON, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-10-4-534 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptRecent interest in the treatment of arthritis, by massive doses of vitamin D,1 has been sufficiently great to warrant a clinical trial of this mode of therapy in a group of patients with the chronic proliferative (infectious) type. Past experience of disappointing results when such recommended therapeutic agents as gold and sulphur were used over an adequately long period under controlled clinical conditions had rendered us somewhat skeptical but it appeared worthwhile, however, to determine if vitamin D might constitute a valuable adjunct to a composite program of treatment in this group of diseases.Thirty-eight patients having chronic infectious or...Bibliography1. DREYERREED ICI: The treatment of arthritis with massive doses of vitamin D Arch. Phys. Therapy, 1935, xvi, 537. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Tucson, Arizona*Received for publication June 22, 1936.From The Wyatt Clinic and Research Laboratories, Tucson, Arizona. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byVitamins as Pharmacologic AgentsThe effects of a single massive dose of vitamin D2 (D-stoss therapy) on oral and other tissues of young dogsVITAMINS D2 AND D3 AND A.T. 10Treatment of rickets and tetany by parenteral administration of one massive dose of vitamin DTreatment of rickets and tetany with a single massive dose of vitamin D 1 October 1936Volume 10, Issue 4Page: 534-536KeywordsArthritisClinical trialsResearch laboratoriesVitamin D ePublished: 1 December 2008 Issue Published: 1 October 1936 PDF downloadLoading ...
Optimal Timing of Coronary Invasive Strategy in Non–ST-Segment Elevation Acute Coronary Syndromes
Authors: Eliano Pio Navarese, Paul Alfred Gurbel, Felicita Andreotti, Udaya S. Tantry, Young-Hoon Jeong, Marek Koziński, Thomas Engstrøm, Giuseppe Di Pasquale, Wacław Kochman, Diego Ardissino, Elvin Kedhi, Gregg W. Stone, Jacek Kubica
Journal: Annals of Internal Medicine (2013)

Debate remains regarding the optimal timing of invasive therapy for patients with non–ST-segment elevation acute coronary syndrome. This meta-analysis assessed available evidence on early versus de...
Cysteine proteases as therapeutic targets: does selectivity matter? A systematic review of calpain and cathepsin inhibitors
Authors: Marton Siklos, Manel BenAissa, Gregory R.J. Thatcher
Journal: Acta Pharmaceutica Sinica B (2015)

Cysteine proteases continue to provide validated targets for treatment of human diseases. In neurodegenerative disorders, multiple cysteine proteases provide targets for enzyme inhibitors, notably caspases, calpains, and cathepsins. The reactive, active-site cysteine provides specificity for many inhibitor designs over other families of proteases, such as aspartate and serine; however, a) inhibitor strategies often use covalent enzyme modification, and b) obtaining selectivity within families of cysteine proteases and their isozymes is problematic. This review provides a general update on strategies for cysteine protease inhibitor design and a focus on cathepsin B and calpain 1 as drug targets for neurodegenerative disorders; the latter focus providing an interesting query for the contemporary assumptions that irreversible, covalent protein modification and low selectivity are anathema to therapeutic safety and efficacy.
General Aspects of Surgery
Authors: Robert G. Louis, Brian J. Williams, Mark E. Shaffrey
Journal: Neuro-Oncology (2012)

Neurosurgical intervention remains the primary method for both definitive diagnosis and treatment of most tumors involving the central nervous system. The goals of these interventions may vary from stereotactic biopsy, to cytoreductive surgery to gross total resection and surgical cure. The literature can at times provide conflicting evidence to suggest which operation might be most beneficial for each particular tumor type. The primary operation in neurosurgical oncology is the craniotomy. Technical innovations such as neuronavigation, intraoperative neurophysiology and real-time image-guided surgery have led to improved rates of resection and, in some cases, improved outcomes. Despite these advances, the range of complications affecting these patients is broad and can lead to significant morbidity and mortality.
Abstract 12533: Mast Cells Induce Vascular Smooth Muscle Cell Apoptosis in Atherosclerotic Plaques via a Toll-Like Receptor 4 Activation Pathway
Authors: Wijnand K den Dekker, Caroline Cheng, Dennie Tempel, Mihai Netea, Jos van der Meer, Henricus J Duckers
Journal: Circulation (2010)

Rationale Vascular smooth muscle cells (VSMCs) play a crucial role in the stabilization of the fibrous cap of atherosclerotic plaques. Activated mast cells may contribute to vulnerable plaque forma...