tbuckley/cabot-search huggingface dataset:
Role of CD11/CD18 in shear rate-dependent leukocyte-endothelial cell interactions in cat mesenteric venules.
Authors: M A Perry, D N Granger
Journal: Journal of Clinical Investigation (1991)

In vivo microscopy was used to assess the relationships among shear rate (and shear stress), leukocyte rolling velocity, and leukocyte adherence in a cat mesentery preparation. Shear rate in individual venules and arterioles of 25-35 microns diameter were varied over a wide range by graded occlusion of an arterial loop. There was a linear decline in leukocyte rolling velocity (Vwbc) as red cell velocity (Vrbc) was reduced. The ratio Vwbc/Vrbc remained constant despite variations in shear stress from 5-25 dyn/cm2. A reduction in shear stress was associated with an increased leukocyte adherence, particularly when Vwbc was reduced below 50 microns/s. Reduction in wall shear rate below 500 s-1 in arterioles allowed 1-3 leukocytes to adhere per 100 microns length of vessel, while venules exposed to the same shear rates had 5-16 adherent leukocytes. In arterioles, leukocyte rolling was only observed at low shear rates. At shear rates less than 250 s-1 leukocyte rolling velocity was faster in arterioles than venules, and the ratio Vwbc/Vrbc for arterioles was 0.08 +/- 0.02, which was fourfold higher than the ratio obtained in venules at similar shear rates. Pretreatment with the CD18-specific antibody (mAb) IB4 increased leukocyte rolling velocity in venules by approximately 20 microns/s at red cell velocities below 2,000 microns/s. mAb IB4 largely prevented the leukocyte adherence to arterioles and venules, and increased the ratio Vwbc/Vrbc observed in venules at low shear elicit a CD18-dependent adhesive interaction between leukocytes and microvascular endothelium, and that differences in shear rates cannot explain the greater propensity for leukocyte rolling and adhesion in venules than arterioles.
777-6 Assessment of Radiofrequency Boiling and Thrombus Formation During Catheter Ablation by Transesophageal Echocardiography
Authors: Yves Gallais, Gilles Lascault, Joelci Tonet, Philip Aouate, Fernando Rosas, Jorge Elias, Osamu Kinoshita, Robert Frank, Guy Fontaine
Journal: Journal of the American College of Cardiology (1995)
Cancer in Adolescents and Young Adults
Authors: James R. Egner
Journal: JAMA (2008)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Threat to break patents saves Brazil $1bn in cost of HIV treatment
Authors: Michael Day
Journal: BMJ (2007)

While biologic disease-modifying antirheumatic drugs (bDMARDs) have transformed outcomes of people with rheumatoid arthritis (RA), a proportion of patients are refractory to multiple bDMARDs. Definitions of refractory RA thus far have been arbitrary, and outcome data and impact of such cohorts remain limited. Extrapolation from randomised controlled trial and some real-life data suggest approximately 20% progress onto a third bDMARD with a more modest proportion failing additional bDMARDs. This viewpoint discusses an opinion of refractory RA disease and proposes key principles to accurately identify refractory cohorts. These include demonstrating presence of persistent inflammation despite multiple therapies and acknowledging development of antidrug antibody. Potential basis of refractory disease is summarised, and suggestions for an initial approach in the future evaluation of refractory disease are offered. Specific investigation of refractory RA disease is necessary to inform the clinical need and provide a basis for robust investigation of underlying mechanisms.
Monomeric and Oligomeric Complexes of the B Cell Antigen Receptor
Authors: Wolfgang W.A Schamel, Michael Reth
Journal: Immunity (2000)

The current structural model of the B cell antigen receptor (BCR) describes it as a symmetric protein complex in which one membrane-bound immunoglobulin molecule (mIg) is noncovalently bound on each side by an Ig-alpha/Ig-beta heterodimer. Using peptide-tagged Ig-alpha proteins, blue native polyacrylamide gel electrophoresis (BN-PAGE), and biosynthetical labeling of B cells, we find that the mIg:Ig-alpha/Ig-beta complex has a stoichiometry of 1:1 and not 1:2. An anti-Flag stimulation of B cells coexpressing Flag-tagged and wild-type Ig-alpha proteins results in the phosphorylation of both Ig-alpha proteins, suggesting that on the surface of living B cells, several BCR monomers are in contact with each other. A BN-PAGE analysis after limited detergent lysis provides further evidence for an oligomeric BCR structure.
982 ANTI-HBC AS A RISK FACTOR FOR THE DEVELOPMENT OF HEPATOCELLULAR CARCINOMA IN PATIENTS WITH ALCOHOLIC CIRRHOSIS: A CROSS-SECTIONAL CASE-CONTROL STUDY
Authors: P.S. Kwon, Y.K. Jung, Yun Soo Kim, J.H. Kim, S.G. Kim, Young Seok Kim, J.I. Lee, J.W. Lee, Young Soo Kim
Journal: Journal of Hepatology (2011)
The Weakening of the Oslerian Tradition
Authors: William Regelson
Journal: JAMA (1978)

SIR William Osler, in his speech on "Teacher and Student" in 1892, said "an academic system without the personal influence of teachers upon pupils, is an arctic winter; it will create an ice bound, petrified, cast-iron university, and nothing else."<sup>1</sup> A generation or two ago, the professor of medicine was molded on the rational and humanistic Oslerian tradition. The essential characteristics of the teacher of medicine were a concern for students and patients and a broad knowledge of clinical medicine. Concern for the patient was a prime responsibility, on a one-to-one basis in a bond of ego and morality that placed the internist as the first arbiter between dissolution and death. The patient was an individual, and the interaction could transcend readily into concerns for economic, family, and emotional factors. The student and house staff were equally involved as people fascinated by the professor's knowledge and performance. The peer
An Otologic Experience in China
Authors: Alfred Coodley
Journal: JAMA (1979)

<h3>To the Editor.—</h3> I would like to express<i>xiexie</i>(Chinese "thank you") to Dr Crawshaw (240:2257, 1978) for his COMMENTARY on Chinese medicine. Because I have also recently returned from a comprehensive trip to China, you might ask what really stood out after seeing it in-depth. As a physician, or even as a psychiatrist, I suspect almost all visitors would watch with great interest, if not astonishment, as major surgery takes place while acupuncture is being used for anesthesia. As a self-appointed architect and engineer, I can say the Great Wall construction is most impressive. As a car buff, my opportunity to walk through the automobile plant in Changchun was stimulating. As a coal mine expert, I know the physical ecstasy of walking down approximately 200 steep steps to observe the open coal mine in action and the sheer torture of walking up what seemed to be 2,000 steps (duck
Thirteenth AACR Special Conference on Cancer Epigenetics
Authors: Jason P. Ross, Peter L. Molloy
Journal: Cancer Research (2010)

Abstract The 13th American Association of Cancer Research (AACR) Special Conference on Cancer Epigenetics was held in San Juan, Puerto Rico, on January 20–23, 2010. This event heralded insights arising from the large sequencing efforts within the NIH Epigenetics Roadmap Project and the Cancer Genome Atlas Project, as well as important new discoveries in the basic biology of epigenetics and results of epigenetic drug clinical trials. A summary of the recent findings is presented here, with particular emphasis on the major themes of the conference. Cancer Res; 70(19); 7372–8. ©2010 AACR.
VARIATION IN RADIATION DOSES FROM NUCLEAR CARDIOLOGY PROCEDURES: RESULTS FROM THE 66 COUNTRY INCAPS (IAEA NUCLEAR CARDIOLOGY PROTOCOLS) STUDY
Authors: Andrew Jeffrey Einstein, Thomas N. Pascual, Joao Vitola, Ganesan Karthikeyan, John Mahmarian, Erin R. Kulick, Mathew Mercuri, Joseph Meeks, Diana Paez, Maurizio Dondi
Journal: Journal of the American College of Cardiology (2014)
Cytogenetic Diagnosis of Down's Syndrome in Utero
Authors: Carlo Valenti
Journal: JAMA (1969)

Fetal cells, obtained by amniocentesis from a balanced carrier of D/G chromosome translocation during the 18th week of pregnancy, were analyzed after 22 days of cultivation in vitro. The karyotypes showed a modal chromosome number of 46, with the D/G fusion chromosome characteristic of Down's syndrome. Pregnancy was interrupted by intra-amniotic instillation of hypertonic saline solution. A 700-gm, macerated, male fetus was delivered and showed dermatoglyphic and anatomic changes compatible with the diagnosis made prenatally.
A Personal Post from Rio
Authors: John Lister
Journal: New England Journal of Medicine (1970)

A WELL known writer once told me that he could do his best writing in the top room of his house in a dense London fog, since this eliminated nearly all external stimuli. I am writing this in Rio de Janeiro on the way back from Buenos Aires, where the Seventh International Diabetic Federation meeting was held, and although it is one of the noisiest cities I have ever visited, and I have been subjected to many unusual external stimuli in the last few weeks, I am far enough from home to be able to reflect in a more detached . . .
GAO: FDA Oversight of Produce Is Poor
Authors: Bridget M. Kuehn
Journal: JAMA (2008)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
THE ACUTE AND SUBACUTE LESIONS INDUCED IN THE SPINAL CORD BY INFECTION OF ITS LYMPH SYSTEM
Authors: D. Orr, R. G. Rows
Journal: BMJ (1912)

MEDICAL JOUnNAL I 1 05 follows :-(1) It can be-easily and quickly performed, provided the details I have suggested are observed.(2) It requires a very much smaller incision and less exposure of Fig. 8.-Fractured femur of a boy of 13. broken in its iupper third, with displacement of its upper fragment in front of the lower..~~~~N
Clonal analysis of erythroid progenitors suggests that pegylated interferon α-2a treatment targets JAK2V617F clones without affecting TET2 mutant cells
Authors: Kiladjian Jj, Massé A, Cassinat B, Mokrani H, Teyssandier I, le Couédic Jp, Cambier N, Almire C, Pronier E, Casadevall N, Vainchenker W, Chomienne C, Delhommeau F
Journal: Leukemia (2010)
299 A novel genetic screen for isolation of neutralizing HCV serine protease single-chain antibodies
Authors: M GALTANAMY, R ZEMEL, L BACHMATOV, Y BERDICHEVSKY, I BENHAR, R TURKASPA
Journal: Hepatology (2003)

Protein tyrosine phosphatase 1B (PTP1B) plays important roles in downregulation of insulin and leptin signaling and is an established therapeutic target for diabetes and obesity. PTP1B is regulated by reactive oxygen species (ROS) produced in response to various stimuli, including insulin. The reversibly oxidized form of the enzyme (PTP1B-OX) is inactive and undergoes profound conformational changes at the active site. We generated conformation-sensor antibodies, in the form of single-chain variable fragments (scFvs), that stabilize PTP1B-OX and thereby inhibit its phosphatase function. Expression of conformation-sensor scFvs as intracellular antibodies (intrabodies) enhanced insulin-induced tyrosyl phosphorylation of the β subunit of the insulin receptor and its substrate IRS-1 and increased insulin-induced phosphorylation of PKB/AKT. Our data suggest that stabilization of the oxidized, inactive form of PTP1B with appropriate therapeutic molecules may offer a paradigm for phosphatase drug development.
Inhibition of rat hepatocyte proliferation by transforming growth factor ? and glucagon is associated with inhibition of ERK2 and p70 S6 kinase
Authors: Mark Dixon, Loranne Agius, Stephen J. Yeaman, Christopher P. Day
Journal: Hepatology (1999)

Stimulation of hepatocyte proliferation by epidermal growth factor (EGF) and insulin is inhibited by transforming growth factor beta (TGF-beta) and by glucagon. It is also suppressed by inhibitors of various protein kinases, including rapamycin, which blocks activation of p70 S6 kinase (p70(S6k)), PD98059, which inhibits the activation of extracellular-regulated kinase (ERK), and SB 203580, an inhibitor of the p38 mitogen-activated protein kinase (p38 MAPK). In this study, we investigated whether the inhibition of proliferation by TGF-beta involves these protein kinase cascades. Culture of hepatocytes with TGF-beta for 16 hours decreased the stimulation by EGF of ERK2 and p70(S6k) (by 50% and 35%, respectively), but did not affect the stimulation of either p38 MAPK, c-jun NH2-terminal kinase (JNK), or protein kinase B (PKB). Culture of hepatocytes with glucagon for 16 hours also inhibited the stimulation by EGF of activation of ERK2 and p70(S6k) (by approximately 50%). The inhibitory effects of glucagon were observed when the hormone was added either 10 minutes or 60 minutes before EGF addition, whereas no effects of TGF-beta were observed after 10-minute or 60-minute incubation. These results suggest that the inhibition of hepatocyte proliferation by TGF-beta may be in part mediated by inhibition of ERK2 and p70(S6k), but does not involve PKB, JNK, or p38 MAPK. Unlike glucagon, the effects of TGF-beta are not elicited in response to short-term treatment.
Growth Factor-Antagonized Rexinoid Apoptosis Involves Permissive PPARγ/RXR Heterodimers to Activate the Intrinsic Death Pathway by NO
Authors: Pattabhiraman Shankaranarayanan, Aurélie Rossin, Harshal Khanwalkar, Susana Alvarez, Rosana Alvarez, Annica Jacobson, Angela Nebbioso, Angel R. de Lera, Lucia Altucci, Hinrich Gronemeyer
Journal: Cancer Cell (2009)
In Early Breast Cancer, Who Does NOT Need Chemo? The Hunt for Prognostic Markers
Authors: C. McNeil
Journal: JNCI Journal of the National Cancer Institute (1998)

In Early Breast Cancer, Who Does NOT Need Chemo?The Hunt for Prognostic Markers for The March, where Sen. Connie Mack (D-Fla.)and newsman Sam Donaldson were among the luminaries to strap in and turn on.While clinicians experience virtual fatigue, researchers work on assessing it.Scales which break fatigue into physical, mental, emotional, and behavioral components are the latest trend, said Kevin Stein, Ph.D., of the Moffitt Cancer Center in Tampa.Stein is one of several researchers who are developing such surveys.He said if you simply ask a patient to rate their fatigue from 1 to 10, "you are not really getting an accurate picture of what the patient is experiencing.But if you break it down into categories, then you can identify the pattern of fatigue in individuals."When asked how this fatigue profiling is useful, Stein said, "There
Q wave and non-Q wave myocardial infarction after thrombolysis
Authors: Shlomi Matetzky, Gabriel I. Barabash, Babeth Rabinowitz, Shmuel Rath, Yedael Har Zahav, Oren Agranat, Elieser Kaplinsky, Hanoch Hod
Journal: Journal of the American College of Cardiology (1995)
ABC of multiple authorship
Authors: G. L Hutchison
Journal: BMJ (1995)

From time to time someone's name appears at the head of a research paper to which they have had not the slightest input.1 There are many possible reasons for this. Perhaps the authors are members of a publication syndicate; or the accessory author is being complimented, or bribed; or the professor has exercised the modern day equivalent of droit de seigneur. One case is unique, however. It is widely known to those in the field and equally widely forgiven. To describe it adequately I must first introduce three physicists.

Hans Bethe was born in Strasbourg in 1906 when the town was part of …
Gout and hyperuricaemia in adults with cystic fibrosis
Authors: Alex Horsley, Jennifer Helm, Amanda Brennan, Rowland Bright-Thomas, Kevin Webb, Andrew Jones
Journal: Journal of the Royal Society of Medicine (2011)

Gout has not been described previously as a complication in cystic fibrosis (CF). Here we present data on nine CF patients who have presented with symptoms of acute gout. This gives an estimated prevalence of gout of around 2.5%in our adult CF population, compared to a previously described prevalence in the non-CF population of just over 1%. Serum urate is measured routinely at the annual review in our unit. Mean (SD) serum urate was 0.40(0.09)mmol/L in male CF patients (n=108) and 0.31 (0.08)mmol/L in female patients (n = 74). This was significantly greater than in historical controls. Thirty-seven percent of male CF patients and 36% of female patients had serum urate levels above the upper limit of normal.
G20 pathologist is suspended and has limits put on his future practice
Authors: C. Dyer
Journal: BMJ (2010)

<h3>Objectives</h3> To complete a 30-year interrupted time-series analysis of the impact of austerity-related and prosperity-related events on the occurrence of suicide across Greece. <h3>Setting</h3> Greece from 1 January 1983 to 31 December 2012. <h3>Participants</h3> A total of 11 505 suicides, 9079 by men and 2426 by women, occurring in Greece over the study period. <h3>Primary and secondary outcomes</h3> National data from the Hellenic Statistical Authority assembled as 360 monthly counts of: all suicides, male suicides, female suicides and all suicides plus potentially misclassified suicides. <h3>Results</h3> In 30 years, the highest months of suicide in Greece occurred in 2012. The passage of new austerity measures in June 2011 marked the beginning of significant, abrupt and sustained increases in total suicides (+35.7%, p&lt;0.001) and male suicides (+18.5%, p&lt;0.01). Sensitivity analyses that figured in undercounting of suicides also found a significant, abrupt and sustained increase in June 2011 (+20.5%, p&lt;0.001). Suicides by men in Greece also underwent a significant, abrupt and sustained increase in October 2008 when the Greek recession began (+13.1%, p&lt;0.01), and an abrupt but temporary increase in April 2012 following a public suicide committed in response to austerity conditions (+29.7%, p&lt;0.05). Suicides by women in Greece also underwent an abrupt and sustained increase in May 2011 following austerity-related events (+35.8%, p&lt;0.05). One prosperity-related event, the January 2002 launch of the Euro in Greece, marked an abrupt but temporary decrease in male suicides (−27.1%, p&lt;0.05). <h3>Conclusions</h3> This is the first multidecade, national analysis of suicide in Greece using monthly data. Select austerity-related events in Greece corresponded to statistically significant increases for suicides overall, as well as for suicides among men and women. The consideration of future austerity measures should give greater weight to the unintended mental health consequences that may follow and the public messaging of these policies and related events.
Intermittent short courses of cyclosporine microemulsion for the long-term management of psoriasis: A 2-year cohort study
Authors: Vincent C.Y. Ho, Christopher E.M. Griffiths, John Berth-Jones, Kim A. Papp, Francisco Vanaclocha, Esteban Dauden, Anna Beard, Lohita Puvanarajan, Carle Paul
Journal: Journal of the American Academy of Dermatology (2001)
Publishing Protocols of Systematic Reviews
Authors: Chris A. Silagy, Philippa Middleton, Sally Hopewell
Journal: JAMA (2002)

Publication of research protocols minimizes bias by explicitly stating a priori hypotheses and methods without prior knowledge of results.We conducted a retrospective comparative study to assess the extent to which the content of published Cochrane reviews had changed compared with their previously published protocols and to assess any potential impact these changes may have had in introducing bias to the study. We identified previously published protocols for new Cochrane reviews appearing in The Cochrane Library; 2000, issue 3. The texts of published protocols and completed reviews were compared. Two raters independently identified changes to the different sections of the protocol and classified the changes as none, minor, or major.Of the 66 new Cochrane reviews, we identified a previously published protocol for 47 reviews. Of these, 43 reviews had at least 1 section that had undergone a major change compared with the most recently published protocol. The greatest variation between protocols and reviews was in the methods section, in which 68% of reviews (n = 32) had undergone a major change. Changes made in other sections that may have resulted in the introduction of bias included narrowing of objectives, addition of comparisons or new outcome measures, broadening of criteria for the types of study design included, and narrowing of types of participants included.Research protocols, even if published, are likely to remain, at least to some extent, iterative documents. We found that a large number of changes were made to Cochrane reviews, some of which could be prone to influence by prior knowledge of results. Even if many of the changes between protocol and review improve the overall study, the reasons for making these should be clearly identified and documented within the final review.