tbuckley/cabot-search huggingface dataset:
The Last of the Morningside Mothers
Authors: Janice T. Moore
Journal: JAMA (2002)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Diyare Ağırlıklı İrritabl Barsak Sendromlu Hastalarda Glutensiz Diyete Klinik Yanıtın Tahmin Göstergeleri
Authors: Ulrich Wahnschaffe, Jörg-Dieter Schulzke, Martin Zeitz, ‡ ve Reiner ULLRICH‡Medical Clinic A, Nutritrion, Greifswald, Medical Clinic I, Charité-Universitätsmedizin Berlin, Campus Benjamin Franklin, Berlin
Journal: Clinical Gastroenterology and Hepatology (2007)
Assessing Eligibility for Anticoagulation After Diagnosis of Atrial Fibrillation
Authors: Marco Marietta, Giulio Formoso, Anna Maria Marata
Journal: JAMA (2015)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
A Manual of Hygiene and Sanitation.
Authors: Seneca Egbert
Journal: JAMA (1898)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Effect of extended follow‐up in a specialized heart failure clinic on adherence to guideline recommended therapy: <scp>NorthStar</scp> Adherence Study
Authors: Morten Schou, Gunnar Gislason, Lars Videbaek, Lars Kober, Christian Tuxen, Christian Torp‐Pedersen, Per R. Hildebrandt, Finn Gustafsson
Journal: European Journal of Heart Failure (2014)
<i>JAMA Internal Medicine</i>Peer Reviewers in 2014
Authors: Rita F. Redberg
Journal: JAMA Internal Medicine (2015)

Onbehalf of the editorial board of JAMA InternalMedicine and our readers, I would like to acknowledge and express heartfelt gratitude to our dedicated reviewerswho completed reviews from January 1, 2014, toDecember 31, 2014. Peer review is the foundation for all of the work of this journal. We depend on the expertise of our dedicated and thoughtful reviewers to help us choose and improve the best manuscripts for our readers. Thank you very much for your invaluable time and insight. Asterisks indicate the number of articles reviewed by thosewho reviewed 3 or more articles.
Abstract 18817: The Four Statin Benefit Groups Defined by the 2013 ACC/AHA Guideline are Characterized by Increased Plasma Level of Electronegative LDL
Authors: Chih-Sheng Chu, Liang-Yin Ke, Hua-Chen Chan, Hsiu-Chua Chan, Chih-Chieh Chen, Kai-Hung Cheng, Hsiang-Chun Lee, Hsuan-Fu Kuo, Ching-Tang Chang, Sheng-Hsiung Sheu, Wen-Ter Lai, Chu-Huang Chen
Journal: Circulation (2014)

Background:  Anion-exchange chromatography has identified L5 as the most electronegative entity of charge-defined LDL subfractions, L1-L5. In patients with ST-elevation myocardial infarction, L5 is markedly elevated and can enhance platelet aggregation. To further evaluate its clinical relevance, we examined plasma L5 distributions in patients classified as the 4 statin benefit groups (atherosclerotic cardiovascular disease, LDL cholesterol >190 mg/dL, diabetes mellitus, 10-year cardiovascular risk score >7.5%) by the 2013 ACC/AHA guideline.    Methods and results:  By examining the medical history and clinical profiles, we divided a cohort of 62 asymptomatic patients (59.4±10.5 yr) with 2 or more components of the metabolic syndrome criteria into the statin benefit (n=44) and non-statin benefit (n=18) groups. Although the plasma LDL cholesterol levels did not differ between groups (147±35 vs. 153±49 mg/dL), the statin benefit group had significantly higher L5/LDL% (5.2±7.3% vs. 2.6±1.9%,  P =0.031) and L5 concentration (7.4±10.4 vs 3.7±3.1 mg/dL,  P =0.036) values. Linear regression showed a positive correlation between the plasma L5 concentration and the 10-year cardiovascular risk scored by the pooled cohort equation (Figure). In cultured human aortic endothelial cells, L5, but not L1-L4, induced release of inflammatory chemokines (CX3CL1, IL-8, IL-6) in a concentration-dependent manner, supporting L5’s role in clinical atherogenicity. Treatment with rosuvastatin (10 mg/day) reduced L5/LDL% and L5 concentration of the statin benefit group to the levels of the non-stating benefit group (2.5±2.1%, 3.4±2.8 mg/dL) in 3 months.   Conclusions:  The 4 statin benefit groups defined by the 2013 ACC/AHA guideline represent a patient population of high cardiovascular risk. The increased risk in this population is closely related to the increased plasma distribution of L5. Statin treatment can decrease the inflammatory property of LDL by reducing its L5 content.
295. Selective Breast Tumor Growth Suppression Mediated by the Enhanced Breast Cancer-Specific Promoter
Authors: Gunnel K. Hallden, Jiang Hui Meng, Richard Hill, Yaohe Wang, Jennelle Francis, Nicholas N. Lemoine, David H. Kirn
Journal: Molecular Therapy (2004)

Several cell culture based models have previously been developed for evaluation of virus and drug interactions in vitro. Here, we report on data using an improved method to demonstrate synergistic (supra-additive) effects of combination treatment with replication competent adenovirus and cytotoxic drugs in mouse and human tumor cell lines in culture. Sensitivity to treatment in all cell lines was determined by dose killing 50% of cells (EC50 values) after single agent treatment and combination therapy of adenovirus type 5 (Ad5) with paclitaxel or cisplatin. Four murine cell lines, CMT-93, CMT-TK, CMT-64, and JC, and three human cell lines LNCaP, H460, and HCT116, were included in the study. Sequencing of virus and drugs and the specific culture conditions for each cell line were evaluated for maximal synergistic effects on cell death. The data demonstrate that treatment with Ad5 in combination with either paclitaxel or cisplatin resulted in a significant supra-additive increase of cell death in CMT-93, CMT-TK and LNCaP cells independent of order of addition. The effects in other cell lines varied from supra-additive to sub-additive and were dependent on culture conditions and sequence of addition of drugs and virus. The human cell lines H460 and HCT116 showed no increase in cell death in response to different conditions for virus and cytotoxic drug combinations and were sub-additive under most test conditions. The enhancement of cell death resulting from the combination treatment appeared dependent on viral replication, no synergy was observed with a replication defective viral mutant. In addition, both cytotoxic drugs could stimulate viral replication under certain conditions. Preliminary data indicate that the conditions for synergy established in cell culture also resulted in enhanced efficacy in vivo.
Chernobyl: Consequences of the Catastrophe for People and the Environment <i>By AlexeyV. Yablokov, Vassily B. Nesterenko, and AlexeyV. Nesterenko</i> , Boston:Blackwell, 2010. 327 pp. ISBN: 978-1-57331-757-3, $150 
Authors: Mona Dreicer
Journal: Environmental Health Perspectives (2010)
Regular review: Management of spontaneous miscarriage in the first trimester: an example of putting informed shared decision making into practice
Authors: W. M Ankum
Journal: BMJ (2001)

1, ultrasonography shows early anembryonic pregnancy or fetal death (missed miscarriage); 2, vaginal bleeding occurs (threatened miscarriage); 3, open cervical os (inevitable miscarriage); 4, miscarriage (products of conception are expelled, and cramps and bleeding soon subside); 5, ultrasonography may show uterine contents -decidua, blood, and some villi.Diagnosis*
Sickle‐cell disease stroke throughout life: A retrospective study in an adult referral center
Authors: Antoine Gueguen, Matthieu Mahevas, Ruben Nzouakou, Hassan Hosseini, Anoosha Habibi, Dora Bachir, Pierre Brugière, François Lionnet, Jean‐Antoine Ribeil, Bertrand Godeau, Robert Girot, Vahid Ibrahima, David Calvet, Frédéric Galactéros, Pablo Bartolucci
Journal: American Journal of Hematology (2013)

Strokes are one of the most severe complications of sickle-cell disease. Most studies have been restricted to children with sickle-cell disease. To better understand the characteristics and follow-up of strokes occurring from childhood to adulthood, we undertook a retrospective cohort study of 69 stroke patients among the 2,875 patients consulting at the French Adult Sickle-Cell Disease Referral Center. Between 1970 and 2008, they had experienced 104 strokes: 80 ischemic, 22 hemorrhagic, and 2 intracranial sinus thromboses. Coma and/or fatal outcomes underscored the severity of strokes in sickle-cell disease patients.Hemorrhagic strokes occurred mostly in adults and carried a higher risk of death than ischemic stroke. The mechanisms underlying sickle-cell disease associated strokes were reevaluated and etiologies were determined for first stroke and recurrences, in childhood and adulthood. Sickle-cell disease vasculopathy concerned only SS patients and remains their most frequent stroke etiology. Cardioembolism, vaso-occlusive crisis and triggering factors were other etiologies identified in adults. Recurrences occurred in 19 SS patients only after a first ischemic stroke. SC patients' strokes occurred in adulthood and were associated with cardiovascular risk factors. Our findings provide novel information about cerebrovascular pathologies throughout the lives of sickle-cell disease patients and suggest the need for different diagnostic and therapeutic management approaches in those different settings.
Physical Medicine and Rehabilitation
Authors: Mark A. Young
Journal: JAMA (1997)

Rehabilitation medicine has a clear but complex mission. As the 13th century physician-philosopher Maimonides once remarked, "To sustain and nurture a man alive in the throes of disease and disability is as great a miracle as to create him." This credo, emblematic of physiatry's calling, is well represented in the pages of Dr Randall L. Braddom's new rehabilitation textbook,<i>Physical Medicine and Rehabilitation</i>. Intended as a revitalized rendition of an earlier classical rehabilitation text,<i>Krusen's Handbook of Physical Medicine and Rehabilitation</i>, this volume aims to expand and modernize its coverage of PM&amp;R. The goal of<i>Physical Medicine and Rehabilitation</i>, according to its editor, is to "meet the needs of the modern practitioner." By providing state-of-the art information, this volume is a nice complement to its legendary predecessor. As one of several formidable physiatry textbooks that have become available in recent years, Braddom's<i>Physical Medicine and Rehabilitation</i>is likely to appeal
Epilepsy Surgery
Authors: Carolyn J. Hildreth, Cassio Lynm, Robert M. Golub
Journal: JAMA (2012)

Jerome Engel, MD, PhD; Michael P. McDermott, PhD; Samuel Wiebe, MD; John T. Langfitt, PhD; John M. Stern, MD; Sandra Dewar, RN; Michael R. Sperling, MD; Irenita Gardiner, RN; Giuseppe Erba, MD; Itzhak Fried, MD, PhD; Margaret Jacobs, BA; Harry V. Vinters, MD; Scott Mintzer, MD; Karl Kieburtz, MD, MPH; for the Early Randomized Surgical Epilepsy Trial (ERSET) Study Group
Treatment of Depression by Mental Health Specialists and Primary Care PhysiciansTreatment of Depression by Mental Health Specialists and Primary Care Physicians
Authors: Harold Alan Pincus
Journal: JAMA (2003)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Hematology of Infancy and Childhood.
Authors: [edited by] David G. Nathan, Frank A. Oski
Journal: Annals of Internal Medicine (1975)

History neonatal haematology bone marrow failure disorders of erythrocyte production haemolytic anemias disorders of haemoglobin the phagocyte system the immune system oncology haemostasis genetics supportive theory haematologic manifestations of systemic diseases.
Polypharmacy in patients with acute exacerbation of COPD
Authors: Jesús Díez-Manglano, José Barquero-Romero, Pedro Almagro-Mena, Joan B. Soriano, Jesús Recio-Iglesias, F. Javier Cabrera-Aguilar
Journal: European Respiratory Journal (2011)

Introduction:  Polypharmacy (PP) is frequent in patients with COPD who often have comorbid chronic diseases, and PP increases the risk to experience adverse drug events.   Objective:  To determine the prevalence of PP in patients hospitalized for an acute exacerbation of COPD, and the factors associated with PP in this population.   Subjects and methods:  ECCO is an observational, prospective, multicentre study. It included those patients admitted with a COPD exacerbation to any of the participating Internal Medicine departments consecutively between January 1, 2007, and December 31, 2008. They were all spirometry-confirmed COPD GOLD II or higher in stable condition. PP was defined as chronic concurrent use of ≥ 5 medications and excessive PP (EPP) as ≥ 10.   Results:  398 patients, 353 men and 45 women, with a mean (SD) age of 73.7 (8.9) years were surveyed. The average use of drugs was 5.0 (2.6). On admission 224 (56.3%) had PP and 22 (5.5%) EPP. Patients with PP had more comorbidity [Charlson index 2.8 (2.8) vs 2.3 (1.6); p=0.004] and more severe mMRC dyspnea (p=0.009) but there were no differences according to GOLD stage. On discharge the average chronic use of drugs was 6.6 (2.4) with an increase in 272 (68.3%) patients. At discharge, 296 patients (78.7%) had PP and 44 (15.9%) EPP. Patients with PP at discharge had more comorbidity and lower FEV1 (p=0.01). In a multivariate logistic regression model PP was associated with lower predicted FEV1, heart failure, hypertension, diabetes, home oxygen therapy and PP on admission.   Conclusion:  Polypharmacy is frequently observed in COPD patients, and is associated with more severity of COPD and more comorbidity.
Abstract 16574: Depressed Left Ventricular Function is the Main Prognostic Marker Despite Cardio-Defibrillator Implantation in Patients With Chagas Heart Disease
Authors: Maria Licia C Cury, Rafael B Pavao, Elerson Arfelli, Adilson Scorzoni_Filho, Jairo R Silva, Antonio Pazin-Filho, Jose A Marin-Neto, Andre Schmidt
Journal: Circulation (2011)

Background: Implantable cardio-defibrillators (ICD) are empirically used to treat patients with Chagas heart disease (CHD) but their effectiveness in this population has not been demonstrated. In a...
The Corticotropin Releasing Factor System in the Kidney: Perspectives for Novel Therapeutic Intervention in Nephrology
Authors: Vassilis Devetzis, Paul Zarogoulidis, Stylianos Kakolyris, Vassilis Vargemezis, Ekaterini Chatzaki
Journal: Medicinal Research Reviews (2012)

Abstract The adaptation to endogenous and exogenous stress stimuli is crucial for survival but also for the onset of various diseases in humans. Corticotropin releasing factor ( CRF ) system is the major regulator of stress response and homeostasis. The members of this family of peptides extend their actions also outside CNS to the periphery where they may affect various body systems independently, acting via vagal and/or autocrine/paracrine pathways. In search for peripheral targets, kidney has rarely been studied separately, regarding expression and action of CRF and CRF ‐related peptides. We reviewed the existing literature concerning expression and action of the CRF system in normal and pathological renal tissue and explored possible clinical implications in nephrology. CRF system components are expressed in the kidney of experimental animals and in humans. The intrarenal distribution is reported to be equally extensive, suggesting a physiological or pathophysiological role in renal function and in the occurrence of renal disease. Urocortins have given multiple interesting observations in experimental models of renal disease and clinical studies, showing robust effects in renal regulation mechanisms. We summarize the relevant data and put them in context, proposing applications with clinical significance in the field of hypertension, diabetic nephropathy, chronic kidney disease, cardiorenal syndrome, and peritoneal dialysis.
Abstract 16595: Airway Ciliary Dysfunction and Increased Postoperative Respiratory Complications in Broad Spectrum of Congenital Heart Disease Patients
Authors: Eileen Stewart, Maliha Zahid, Omar Khalifa, Ricardo Munoz, Brian Feingold, Peter Wearden, William Devine, Linda Leatherbury, Cecilia W Lo
Journal: Circulation (2014)

Introduction: Congenital heart disease (CHD) patients with heterotaxy (HTX) have high prevalence of airway ciliary dysfunction (CD). This is associated with higher postoperative morbidity and more respiratory complications. As a high prevalence of airway CD is also observed in CHD patients without HTX, we hypothesize patients with broad spectrum of CHD may have increased postoperative morbidity associated with airway CD. Methods: CHD patients &lt;1 yr undergoing cardiac surgery were recruited. CD testing was conducted with two tests used for primary ciliary dyskinesia (PCD) diagnosis: nasal nitric oxide (nNO) was measured, typically low with PCD, and nasal scrape was obtained for ciliary motion (CM) analysis with videomicroscopy. Data on post-operative outcome parameters were collected. Results: We recruited 55 CHD patients with 76 surgical events; 38% had airway CD (low nNO/ abnormal CM). Demographics and surgical complexity scores were similar between patients with or without CD. In CHD patients with CD, there was significant increase in continuous positive airway pressure ventilation (CPAP) (p = 0.008) and trend for more reintubation (11% non-CD vs. 27% CD patients) (Table 1). There was significant increase in beta-agonist use in CD patients (p = 0.006) and five-fold increase in respiratory medication use (Table 1). No difference was observed in length of stay, ventilator days, overall supportive ventilation (CPAP, high flow nasal cannula, nasal cannula), use of pulmonary vasodilators, chest tube days, effusion, or need for extracorporeal membrane oxygenation (ECMO). Conclusions: CHD patients with airway CD have increased postoperative morbidity, including increased need for CPAP, more use of albuterol and respiratory medications, and more reintubations. These results suggest CHD patients may benefit from presurgical screening for airway CD, with those identified with CD given perioperative respiratory therapy to reduce postoperative morbidity.