Tremor Induced by Trimethoprim-Sulfamethoxazole in Patients with the Acquired Immunodeficiency Syndrome (AIDS)
Authors: Michael J. Borucki
Journal: Annals of Internal Medicine (1988)

Brief Reports1 July 1988Tremor Induced by Trimethoprim-Sulfamethoxazole in Patients with the Acquired Immunodeficiency Syndrome (AIDS)Michael J. Borucki, MD, Debbie S. Matzke, MD, Richard B. Pollard, MDMichael J. Borucki, MD, Debbie S. Matzke, MD, Richard B. Pollard, MDAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-109-1-77 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptPatients with the acquired immunodeficiency syndrome (AIDS) treated with trimethoprim-sulfamethoxazole for Pneumocystis carinii pneumonia often have adverse reactions, with a frequency of 83% reported in one series (1). Only 14% of persons without AIDS have side effects with treatment for P. carinii pneumonia (2).Adverse neurologic reactions to trimethoprim-sulfamethoxazole, including headaches, depression, and hallucinations, rarely occur (3, 4) in normal persons, and have rarely been described in patients with AIDS. Of 80 patients with AIDS treated with trimethoprim-sulfamethoxazole, 1 had a focal seizure (5). Another report showed 2 patients with AIDS who developed ataxia while taking trimethoprim-sulfamethoxazole (6). In another...References1. Gordin F, Simon G, Wofsy C, and Mills J. Adverse reactions to trimethoprim-sulfamethoxazole in patients with the acquired immunodeficiency syndrome. Ann Intern Med. 1984;100:495-9. LinkGoogle Scholar2. Hughes W, Feldman S, and Sanyal S. Treatment of Pneumocystis carinii pneumonitis with trimethoprim-sulfamethoxazole. Can Med Assoc J. 1975;112(Suppl):47S-50S. MedlineGoogle Scholar3. Frisch J. Clinical experience with adverse reactions to trimethoprim-sulfamethoxazole. J Infect Dis. 1973;128(Suppl):S607-12. CrossrefGoogle Scholar4. Salter A. Trimethoprim-sulfamethoxazole: an assessment of more than 12 years of use. Rev Infect Dis. 1982;4:196-236. CrossrefMedlineGoogle Scholar5. Winston D, Lau W, Gale R, and Young L. Trimethoprim-sulfamethoxazole for the treatment of Pneumocystis carinii pneumonia. Ann Intern Med. 1980;92:762-69. LinkGoogle Scholar6. Liu L, Seward S, and Crumpacker C. Intravenous trimethoprim-sulfamethoxazole and ataxia [Letter]. Ann Intern Med. 1986;104:448. LinkGoogle Scholar7. Jaffe H, Abrams D, Ammann A, Lewis B, and Golden J. Complications of co-trimoxazole in treatment of AIDS-associated Pneumocystis carinii pneumonia in homosexual men. Lancet. 1983;2:1109-11. CrossrefMedlineGoogle Scholar8. Navia B, Jordan B, and Price R. The AIDS dementia complex: I. Clinical features. Ann Neurol. 1986;19:517-24. CrossrefMedlineGoogle Scholar9. Smith I, Howells D, Kendall B, Levinsky R, and Hyland K. Folate deficiency and demyelination in AIDS [Letter]. Lancet. 1987;2:215. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: Michael J. Borucki, MD; Debbie S. Matzke, MD; Richard B. Pollard, MDFrom University of Texas Medical Branch, Galveston, Texas. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byDrug-induced tremorsCortical myoclonic tremor after chimeric antigen receptor T-cell therapyAcute movement disorders in the medical settingSulfonamidesTrimethoprim and co-trimoxazoleMedication-induced tremorsToolbox: Neuropsychiatric adverse effects of antimicrobial agentsTetrahydrobiopterin Biosynthesis as an Off-Target of Sulfa DrugsOther TremorsHyperkinetic movement disorders associated with HIV and other viral infectionsHIV Infection and Movement DisordersANTIBACTERIAL DRUGSSulfonamidesTrimethoprim and co-trimoxazoleDrug-induced tremorsTREMORS AND CHOREA INDUCED BY TRIMETHOPRIM-SULFAMETHOXAZOLE IN A CHILD WITH PNEUMOCYSTIS PNEUMONIADrug- and Toxin-Induced TremorMovement disorders and AIDS: a reviewOther Drug-induced Movement DisordersDrug-induced ParkinsonismMultifocal Myoclonus Induced by Trimethoprim–Sulfamethoxazole Therapy in a Patient with Nocardia InfectionAdverse Reactions to Trimethoprim/Sulfamethoxazole in AIDSAcute delirium induced by intravenous trimethoprim–sulfamethoxazole therapy in a patient with the Acquired Immunodeficiency SyndromeTrimethoprim/Sulfamethoxazole-Induced Tremor in a Patient with AIDSACUTE RESPIRATORY FAILURE IN THE HIV-SEROPOSITIVE PATIENTPNEUMOCYSTIS CARINIIMiscellaneous antibacterial and antiviral drugsDrug-Induced EncephalopathyMiscellaneous antibacterial and antiviral drugs 1 July 1988Volume 109, Issue 1Page: 77-78KeywordsAIDSAdverse reactionsAtaxiaEpileptic seizuresHallucinationsPneumocystis carinii pneumoniaPneumoniaVirology ePublished: 1 December 2008 Issue Published: 1 July 1988 PDF downloadLoading ...