tbuckley/cabot-search huggingface dataset:
Abstract 15891: Age-Related Changes of Right Atrial and Right Ventricular Functions Assessed by Speckle Tracking Echocardiography
Authors: Roxana Cristina G Rimbas, Simona Ionela Calin, Oana Aurelia Enescu, Sorina Mihaila, Dragos Vinereanu
Journal: Circulation (2014)

Introduction: Limited data are reported about age-related changes of the RA phasic functions, assessed by speckle tracking echocardiography (STE), and their correlation with the RV function. Methods: 131 normal subjects (19-78 yrs, 89 women), divided in 4 age groups, were studied by conventional, tissue Doppler, and STE. Active RA function was assessed from negative global strain at atrial contraction (GSA-) and derived time from P onset (TGSA-), and late diastolic SR (GSRL); passive function from positive global strain at TVO (GSA+) and time from R to peak (TGSA+), and from early negative diastolic global strain rate (GSRE); reservoir function from the sum of GSA- and GSA+ (SUMGSA), positive global SR at the beginning of RV systole (GSR+) and derived time from P onset (TGSR+). RA volumes were measured. RV systolic function was assessed from TAPSE, FAC, S’, global systolic strain (GS) and strain rate (RVSRs); diastolic function from early and late global SR (RVSRe and RVSRl). Results: Active RA function was not affected by age, but RA contraction time was longer over 50 yrs. Reservoir function decreased starting from 50 yrs (GRS+), but especially over 60 yrs (SUMGSA, TGRS+). Passive function also decreased over 50 yrs (GSA+, TGSA+, GSRE). RV systolic function was not affected by age, whereas RVSRe decreased, and RVSRl increased over 50 yrs (Table). Global RV function (TAPSE, FAC) did not correlate with any of the RA functions. However, longitudinal RV systolic function (RVSRs, GS, S’) correlated inversely with active function (GSA-, GSRL). RVSRe had positive correlation with RA reservoir (SUMGSA, GSR+), and also with passive function (GSA+, GSRE) (r=0.4, p&lt;0.001). Atrial volumes were not affected by age. Conclusion: Active RA function is not affected by age. Passive and reservoir RA functions, and diastolic RV function decreased over 50 yrs. Longitudinal systolic RV correlates with active RA function, and diastolic RV function with passive and reservoir RA functions.
Giving Bad News Reminds Me of You
Authors: Doug Hester
Journal: Annals of Internal Medicine (2015)

Ad Libitum16 June 2015Giving Bad News Reminds Me of YouDoug HesterDoug HesterFrom Nashville, Tennessee.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/M15-0397 Audio Reading - "Giving Bad News Reminds Me of You" Audio. Michael A. LaCombe, MD, Annals Associate Editor, reads "Giving Bad News Reminds Me of You," by D. Hester. Your browser does not support the audio element. Audio player progress bar Step backward in current audio track Play current audio trackPause current audio track Step forward in current audio track Mute current audio trackUnmute current audio track 00:00/ SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail Storms rise, releasing an old memoryof your death. But this time I'm the giverof rites, sitting in my scrubs and white coat.The rusty words sound familiar as theyrain down on his newborn widow. I wantto tell her about you, to tell her Iburied a spouse, but instead I stare atthe plastic roses backlit by lightning.Here with her I hear thunder, lumberingand jagged, fracture and grind as the stormreels outside the Family Room's windows.Dry-eyed, she looks through me before stumblingbeyond sound, clutching each breath in fear hismemories will flee in exhalation.Doug HesterNashville, Tennessee Author, Article, and Disclosure InformationAffiliations: From Nashville, Tennessee.Current Author Address: Doug Hester; e-mail, doug.[email protected]edu. PreviousarticleNextarticle Advertisement Audio Reading - "Giving Bad News Reminds Me of You" Audio. Michael A. LaCombe, MD, Annals Associate Editor, reads "Giving Bad News Reminds Me of You," by D. Hester. Your browser does not support the audio element. Audio player progress bar Step backward in current audio track Play current audio trackPause current audio track Step forward in current audio track Mute current audio trackUnmute current audio track 00:00/ FiguresReferencesRelatedDetails Metrics 16 June 2015Volume 162, Issue 12Page: 859KeywordsFearMemoryStorms ePublished: 16 June 2015 Issue Published: 16 June 2015 Copyright & PermissionsCopyright © 2015 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Infections caused by carbapenem-resistant Klebsiella pneumoniae among patients in intensive care units in Greece: a multi-centre study on clinical outcome and therapeutic options
Authors: F. Kontopidou, H. Giamarellou, P. Katerelos, A. Maragos, I. Kioumis, E. Trikka-Graphakos, C. Valakis, H.C. Maltezou
Journal: Clinical Microbiology and Infection (2013)
Histopathologic and immunocytochemical analysis of the retina and ocular tissues in batten disease
Authors: Thouria Bensaoula, Hisashi Shibuya, Martin L Katz, Julie E Smith, Gary S Johnson, Sinoj K John, Ann H Milam
Journal: Ophthalmology (2000)

Purpose To describe the pathophysiologic features of retinal degeneration in Batten disease (juvenile neuronal ceroid lipofuscinosis [JNCL]) caused by mutations in the CLN3 gene. Study design Comparative human tissue study. Materials The retina and other ocular tissues of a 22-year-old man with JNCL were compared with the same tissues of a healthy 30-year-old man. DNA from whole blood and RNA from retina were used for genotype analysis. Methods The retinas, corneas, conjunctiva, and ciliary body were processed for histopathologic and immunofluorescence analysis. Genomic DNA was subjected to polymerase chain reaction (PCR) and nucleotide sequence analyses. Reverse transcriptase/PCR and sequence analysis were performed on retinal RNA. Results The JNCL donor was heterozygous for a ∼1 kb deletion in CLN3, as found in most JNCL patients. The other allele had a single base pair deletion in exon 6 that resulted in a frame shift. Gross pathology of the JNCL retina resembled that in retinitis pigmentosa, including deposits of bone spicule pigment. Histopathologic studies revealed loss of neurons from all retinal layers. Immunofluorescence labeling with antibodies to rhodopsin, recoverin, and cone opsin demonstrated degenerate rods and cones with short outer segments in the far periphery. Autofluorescent lipopigment granules were prominent in ganglion cells and some cells of the inner nuclear layer, but not in the photoreceptors. The retinal pigment epithelium (RPE) had fewer lipofuscin granules than the control specimen. Increased numbers of lipofuscin granules were found in the epithelia of the ciliary body and conjunctiva, but not in the cornea of the JNCL eye. Conclusions Immunofluorescence studies revealed degenerate rods and cones in the far periphery. Lipofuscin granules were decreased in the RPE, consistent with loss of photoreceptor outer segments. The novel finding that degenerate photoreceptors did not contain autofluorescent inclusions suggests that granule accumulation may not precede photoreceptor degeneration in JNCL. The presence of normal photoreceptor proteins in the degenerate rods and cones suggests that these cells may be capable of functional regeneration if a therapy for Batten disease is developed.
Book: Conflict in General Practice
Authors: R. Neal
Journal: BMJ (1998)

Lynne A Hobden-Clarke, Susan A T Law Royal Society of Medicine Press, £17.50, pp 208 ISBN 0443059365 Rating: ![Graphic][1]</img>![Graphic][2]</img> Taken literally, conflict, defined either as a fight or a struggle or as a clashing of opposed principles, pervades medicine. Such conflict ranges from differences of opinion with professional colleagues to dissatisfaction with health service management and ongoing battles with poorly compliant patients. It is all part of a day's work for most doctors. The concept of … [1]: /embed/inline-graphic-1.gif [2]: /embed/inline-graphic-2.gif
Abstract 8924: Heterochromatin Protein 1 Acts as an Intra-nuclear Redox Sensor
Authors: Shuichiro Higo, Yoshihiro Asano, Hisakazu Kato, Atsushi Nakano, Osamu Tsukamoto, Issei Komuro, Masafumi Kitakaze, Seiji Takashima
Journal: Circulation (2010)

Background: Pro-atherogenic stimuli generates reactive oxygen species (ROS) in endothelial cells. To adapt to extrinsic ROS, cells possess the protective mechanisms using various sensor proteins in...
Abstract 15178: Assessment of Optical Coherence Tomogaphic Findings between Cobalt-Chromium Everolimus-Eluting Stents and New Generation Drug-Eluting Stents
Authors: Hirofumi Ohtani
Journal: Circulation (2014)

Introduction: Uncovered and malapposed stent struts are risk of stent thrombosis in drug-eluting stents (DES). Second-generation DESs improved endothelial coverage and reduced stent thrombosis rate compared to those of first-generation DESs. However few studies have directly compared stent coverage using OCT between second-generation DESs (CoCr-EES or R-ZES) and new generation drug-eluting stents (platinum-chromium EES; PtCr-EES). The aim of this study is to compare OCT findings between CoCr-EES, R-ZES and PtCr-EES at 9 months after stent implantation. Methods: Total of 30 patients who underwent single stent implantation in de novo coronary arteries leasions without target lesion revascularization were included (10 CoCr-EESs, 10 PtCr-EESs and 10 R-ZESs). Cross-sectional OCT images were analyzed at 1-mm intervals. At every cross-section (CS), stent area and neointimal hyperplasia area (NIA) were measured and percent NIA [(NIA /stent area)[[Unable to Display Character: &amp;#9747;]]100] were calculated. For each strut, neointimal thickness (NIT), malapposed and uncovered struts were assessed. Strut malapposition was defined as detachment from the vesell wall by &gt;90μm for CoCr-EES, by &gt;100μm for R-ZES, or by &gt;90μm for PtCr-EES. Results: Total of 4646 struts and 588 CS were analyzed. Baseline patient and lesion characteristics were similar between 3 groups. In CoCr-EESs, NIT was thinner than the others (CoCr-EES: 70μm (30-130μm) vs. R-ZES: 80μm (40-150μm) vs. PtCr-EES: 90μm (50-140μm); p=0.0001). The percent NIA were similar among the groups (R-ZES: 8.1% vs. CoCr-EESs: 8.4% vs. PtCr-EES: 10%; p=0.18). PtCr-EESs had less frequency of malapposed (PtCr-EES: 0.08% vs. CoCr-EES: 0.4% vs. R-ZES: 0.9%, p=0.005) and uncovered (PtCr-EES: 0.94% vs. R-ZES: 2.2% vs. CoCr-EES: 3.4%; p=0.0001) struts than the others. Conclusions: PtCr-EESs had fewer uncovered struts and better stent apposition although greater NIT than CoCr-EESs and R-ZESs. These findings may suggest the fewer risks for stent thrombosis in PtCr-EESs.
Abstract P190: The Associations of Brachial Artery Shear Rate and Endothelial Dysfunction with Age Related Carotid Distensibility
Authors: Dhananjay Vaidya, Yan Zhang, Brian G Kral, Lisa R Yanek, Lewis C Becker, Diane M Becker
Journal: Circulation (2015)

Loss of carotid artery distensibility (CD) with age portends of clinical cerebrovascular disease. Endothelial dysfunction mediated by impaired nitric oxide vascular dilatation precedes vascular remodeling and age-related stiffening of arteries. However, it is unknown whether endothelial dysfunction contributes to loss of vascular distensibility with age. Methods: We examined 828 asymptomatic healthy subjects in the GeneSTAR family cohort, identified from index cases with early-onset coronary artery disease. We determined mean CD of both common carotid arteries using ultrasound; CD was quantified as the pulsatile change in lumen diameter/diastolic lumen diameter/brachial pulse pressure. Vascular shear rate (SR) was determined in the brachial artery as 4 х maximum blood flow velocity/maximum lumen diameter, and brachial flow mediated dilatation (FMD), a measure of endothelial dysfunction, as % change in diastolic diameter during reactive hyperemia. We tabulated both rest and hyperemic responses by age, sex and race-indexed tertiles of CD generated by quantile regression. Generalized estimating equations (GEE) were used to estimate the family correlation corrected associations of CD with FMD and SR. Results: The sample was 60% female, 40% African American, with mean age 52 (SD 12) years. While SR was significantly associated with higher tertiles of CD, FMD was not (Table). Adjusted for age, sex and race, every 540/s (1 SD) higher of shear rate was significantly associated with a 6.2% higher CD (p = 0.019) but FMD was not associated at all (p = 0.54). This pattern remained after adjustment for LDL and HDL- cholesterol, hypertension, diabetes and smoking (p = 0.03 and 0.95, respectively). Conclusion: Higher vascular shear rate is associated with preserved arterial distensibility indexed for age. FMD is not related to CD. The pathophysiological interpretations of this finding need further study before either CD or vascular shear rate can be used for assessing stoke risk in a population at increased risk for vascular disease.
The impact of race, age, and sex in follicular lymphoma: A comprehensive SEER analysis across consecutive treatment eras
Authors: Chadi Nabhan, Briseis Aschebrook‐Kilfoy, Brian C‐H Chiu, Kimberly Kruczek, Sonali M. Smith, Andrew M. Evens
Journal: American Journal of Hematology (2014)

The impact of race/ethnicity and the additional factors of age, sex, and socioeconomic status (SES) on follicular lymphoma (FL) outcomes have not been comprehensively studied and are not well defined. We examined population-based FL data from >18,000 patients in SEER-13 (1992-2009) investigating race/ethnicity and the impact of relevant factors including sex, age, and SES. Further, we compared data over two consecutive periods: Era-1 (1992-2000, n = 8,355) and Era-2 (2001-2009, n = 10,475). We identified 18,830 FL patients (White: n = 15,116; Hispanic: n = 1,627; Asian/Pacific Islander (A/PI): n = 1,002; and Black: n = 846). Median ages (years) differed significantly by race/ethnicity: White: 62.1, Hispanic: 57.3, A/PI: 60.7, and Black: 56.8 (P < 0.01 each race versus White). Overall survival (OS) was superior in Era-2 versus Era-1 for all patients (5-year: 76.7% versus 67.4%, respectively, P < 0.001). Further, survival was significantly improved for all age groups <80 years, for males (P = 0.0019), and females (P < 0.001) across eras. Females had superior OS compared with males in Era-1 (P = 0.004), but not in Era-2. Additionally, all races, except A/PI, had improved 5-year OS rates from Era-1 to Era-2. Finally, OS improved across eras for lower and higher SES populations; however those with higher SES were superior to lower SES patients in both eras. In conclusion, and in the largest comprehensive evaluation of US-based FL patients to date, we show that despite improvements in OS for FL over time, critical disparities across races/ethnicities, sex, and age groups remain in the modern era and warrant further studies.
Crying in the Curriculum
Authors: N R Angoff
Journal: JAMA (2001)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Cytokines and chemokines in the airway epithelial lining fluid are down-regulated in newborns of atopic mothers
Authors: Nilofar Følsgaard, Bo L.K. Chawes, Morten A. Rasmussen, Klaus Bonnelykke, Susanne Brix, Hans Bisgaard
Journal: European Respiratory Journal (2011)

Background: We have analyzed cytokines and chemokines in the nasal airway epithelial lining fluid in asymptomatic neonates born of atopic and non-atopic parents.

Method: 18 cytokines and chemokines were assessed in the nasal airway epithelial lining fluid in 309 1 month old neonates from the novel unselected Copenhagen Prospective Study on Asthma in Childhood (COPSAC2010) birth cohort. 56% of mothers and 47% of fathers had a history of asthma, allergy and/or eczema.

Results: Children with atopic mothers had significantly lower levels of CCL26 (eotaxin-3); CXCL10 (IP-10); IFNγ, IL13, IL1β,IL2, IL4, CXCL8 (IL8), TNFα, CCL11 (Eotaxin-1), CCL2 (MCP-1), CCL13 (MCP4) and CCL22 (MDC), compared to children of non-atopic mothers: and exhibited a non-significant trend of lower levels of IL10, IL12p70, IL5, CCL4 (MIP-1β) and CCL17 (TARC); while none of the cytokines or chemokines exhibited trend of high levels in children of atopic mothers.

Father's atopic status was not significantly associated with the level of these mediators.

Conclusion: Maternal atopy (but not paternal) is associated with a general down-regulation of Th1, Th2 and regulatory cytokines and chemokines in the nasal airway epithelial lining fluid in asymptomatic neonates.
S100A1 DNA-based Inotropic Therapy Protects Against Proarrhythmogenic Ryanodine Receptor 2 Dysfunction
Authors: Julia Ritterhoff, Mirko Völkers, Andreas Seitz, Kristin Spaich, Erhe Gao, Karsten Peppel, Sven T Pleger, Wolfram H Zimmermann, Oliver Friedrich, Rainer H A Fink, Walter J Koch, Hugo A Katus, Patrick Most
Journal: Molecular Therapy (2015)

Restoring expression levels of the EF-hand calcium (Ca(2+)) sensor protein S100A1 has emerged as a key factor in reconstituting normal Ca(2+) handling in failing myocardium. Improved sarcoplasmic reticulum (SR) function with enhanced Ca(2+) resequestration appears critical for S100A1's cyclic adenosine monophosphate-independent inotropic effects but raises concerns about potential diastolic SR Ca(2+) leakage that might trigger fatal arrhythmias. This study shows for the first time a diminished interaction between S100A1 and ryanodine receptors (RyR2s) in experimental HF. Restoring this link in failing cardiomyocytes, engineered heart tissue and mouse hearts, respectively, by means of adenoviral and adeno-associated viral S100A1 cDNA delivery normalizes diastolic RyR2 function and protects against Ca(2+)- and β-adrenergic receptor-triggered proarrhythmogenic SR Ca(2+) leakage in vitro and in vivo. S100A1 inhibits diastolic SR Ca(2+) leakage despite aberrant RyR2 phosphorylation via protein kinase A and calmodulin-dependent kinase II and stoichiometry with accessory modulators such as calmodulin, FKBP12.6 or sorcin. Our findings demonstrate that S100A1 is a regulator of diastolic RyR2 activity and beneficially modulates diastolic RyR2 dysfunction. S100A1 interaction with the RyR2 is sufficient to protect against basal and catecholamine-triggered arrhythmic SR Ca(2+) leak in HF, combining antiarrhythmic potency with chronic inotropic actions.
Abstract 2211: Left Ventricular Stroke Volume Values Measured by 2- D Echocardiographic Volumetric and Doppler-Based Methods Cannot be Used Interchangeably
Authors: Eddy Barasch, Jing Han, Florentina Petillo, Michael Passick, Nathaniel Reichek
Journal: Circulation (2008)

The values of left ventricular stroke volume (SV) measured by Doppler and 2-D echo are frequently reported as if they were interchangeable. No systematic evaluation of the agreement between these methods has been done. To determine the agreement, correlation and reproducibility of SV values measured by 2-D echo and Doppler methods. 107 healthy subjects (mean age 59 ± 14 yrs, 59 % females), had comprehensive echocardiographic evaluation. 2-D LV volumes (2D) were measured by the biplane Simpson’s method. For Doppler, the product of the area of the LV outflow tract (LVOT) x LVOT time velocity integral (TVI), and the area of aortic annulus (AA), and the product of aortic cusp separation (ACS) x aortic TVI were used. Mixed model analysis of variance was performed and Bland Altman agreement limits, Pearson correlation and within-subject coefficient of variation and intraclass correlation coefficient were determined. The mean SV (ml/beat) measured by 2-D and Doppler methods using LVOT, AA and ACS area were: 64 ± 18, 65 ± 15, 76±14, 70 ± 16, respectively. No differences were found between LVOT and 2-D (p = 0.99), borderline between LVOT and ACS (p = 0.051) and significant differences were found between all the other methods. The within-subject coefficient of variation was 19.3% and the intraclass correlation coefficient =0.71, for all the methods indicating good reproducibility. Bland Altman 95% agreement limits for LVOT vs. 2-D were −38.0 and 38.6 ml/beat. The correlation coefficients for all 4 methods are given below. 1. In healthy subjects, although no significant differences were found between mean SV values measured by 2-D and Doppler LVOT methods, the correlation was weak and the agreement limits were large. 2. There was a modest correlation between the Doppler methods and between AA, ACS and 2-D, but the mean SV values were significantly different. 3. SV values measured by these 4 methods cannot be used interchangeably.
Dopamine blockade and clinical response: evidence for two biological subgroups of schizophrenia
Authors: A Wolkin, F Barouche, A P Wolf, J Rotrosen, J S Fowler, C Y Shiue, T B Cooper, J D Brodie
Journal: American Journal of Psychiatry (1989)

Because CNS neuroleptic concentration cannot be directly measured in patients, the relation between clinical response and extent of dopamine receptor blockade is unknown. This relationship is critical in ascertaining whether nonresponse to neuroleptics is the result merely of inadequate CNS drug levels or of more basic biological differences in pathophysiology. Using [18F]N-methylspiroperidol and positron emission tomography, the authors assessed dopamine receptor occupancy in 10 schizophrenic patients before and after treatment with haloperidol. Responders and nonresponders had virtually identical indices of [18F]N-methylspiroperidol uptake after treatment, indicating that failure to respond clinically was not a function of neuroleptic uptake or binding in the CNS.