Gastrin and Islet-Cell Tumors
Authors: Jens Fr. Rehfeld, Flemming Stadil, Lars-Inge Larsson, Frank Sundler, Rolf Håkanson
Journal: Annals of Internal Medicine (1974)

Comments1 June 1974Gastrin and Islet-Cell TumorsJENS FR. REHFELD, M.D., FLEMMING STADIL, M.D., LARS-INGE LARSSON, M.D., FRANK SUNDLER, M.D., ROLF HÅKANSON, M.D.JENS FR. REHFELD, M.D.Search for more papers by this author, FLEMMING STADIL, M.D.Search for more papers by this author, LARS-INGE LARSSON, M.D.Search for more papers by this author, FRANK SUNDLER, M.D.Search for more papers by this author, ROLF HÅKANSON, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-80-6-778 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: The NIH conference on current concepts of islet cell tumors (1) contains some questionable statements about gastrin, which may justify the following comments.1. In the summary (page 239) and later (page 243), it is stated that an increase of circulating "big" gastrin may be the most specific finding in the Zollinger-Ellison syndrome. The references cited in that context (their References 55 and 56) do not support such a suggestion. On the contrary, it has been shown that the fraction of "big" gastrin, (preferably called gastrin-33*[2]) in serum from Zollinger-Ellison patients is of the same order...References1. SCHEINDELELLISKAHN PRC: Islet cell tumors: current concepts and management. Ann Intern Med 79:239-257, 1973 LinkGoogle Scholar2. REHFELD J: Gastrins in serum. Scand J Gastroenterol 8:577-583, 1973 CrossrefMedlineGoogle Scholar3. REHFELDSTADIL JF: "Big gastrins" in the Zollinger-Ellison syndrome (letter). Lancet 2:1200, 1972 CrossrefMedlineGoogle Scholar4. REHFELD J: Three components of gastrin in human serum. Biochem Biophys Acta 285:364-372, 1972 MedlineGoogle Scholar5. REHFELDSTADIL JF: Gel filtration studies on immunoreactive gastrin in serum from Zollinger-Ellison patients. Gut 14:369-373, 1973 CrossrefMedlineGoogle Scholar6. LOMSKYLANGRVORTEL RFV: Immunohistochemical demonstration of gastrin in mammalian islets of Langerhans. Nature (Lond) 223:618-619, 1969 CrossrefMedlineGoogle Scholar7. GREIDERMCGUIGAN MJ: Cellular localization of gastrin in the human pancreas. Diabetes 20:389-396, 1971 CrossrefGoogle Scholar8. POLAKSTAGGPEARSE JBA: Two types of Zollinger-Ellison syndrome: immunofluorescent, cytochemical and ultrastructural studies of the antral and pancreatic gastrin cells in different clinical states. Gut 13:501-512, 1972 CrossrefMedlineGoogle Scholar9. LARSSONLJUNGBERGSUNDLER LOF: Antro-pyloric gastrinoma associated with pancreatic nesidioblastosis and proliferation of islets. Virchows Arch [Pathol Anat] 360:305-314, 1973 CrossrefMedlineGoogle Scholar10. VASSALLOSOLCIABUSSOLATI GEG: Non-G cell-producing tumours of the pancreas. Virchows Arch [Pathol Anat] 11:66-79, 1972 Google Scholar11. HÅKANSON R: New aspects of the formation and function of histamine, 5-hydroxytryptamine and dopamine in gastric mucosa. Acta Physiol Scand [Suppl] 340, 1970 Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: *WALSH JH, TROUT HH, DEBAS HT, et al: Immunochemical and biological properties of gastrins obtained from different species and of different molecular species of gastrins. Symposium on Recent Advances in Gastrointestinal Hormone Research, August 1973, Rochester, New York, edited by CHEY WY. In press. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 June 1974Volume 80, Issue 6Page: 778-778KeywordsGastrinHormonesZollinger Ellison syndrome ePublished: 1 December 2008 Issue Published: 1 June 1974 PDF downloadLoading ...