tbuckley/cabot-search huggingface dataset:
Abstract P037: Effect of a Family Based Intervention on Biomarkers of Diet Quality/Endogenous Metabolism and BMI z-score
Authors: Nirupa R Matthan, Xiaonan Xue, Qi Gao, Judith Wylie-Rosett, Alice H Lichtenstein
Journal: Circulation (2015)

Developing strategies to prevent excess weight gain during childhood is critical to support efforts to stem the current juvenile obesity epidemic and associated long-term adverse cardiometabolic consequences. The objective was to assess how participation in a family-based weight management intervention affected biomarkers of diet quality/endogenous metabolism and cardiometabolic outcomes in children aged 7-12 years (n=309) with baseline BMI z-score (BMIz) >85th percentile. Families were randomized to a control group, receiving a booklet targeting healthy eating behaviors/increasing physical activity, and quarterly visits to review lifestyle recommendations or an experimental group, receiving weekly sessions for 3 months including targeted diet strategies (increasing highly pigmented fruit/vegetable and fish intake; substituting non-fat/low-fat for full-fat dairy products; and reducing meat, fried food and savory snack intakes) and physical activity curriculum followed by 9 monthly sessions. Biomarkers of nutrient intake and metabolism (RBC fatty acid profiles, plasma carotenoids, vitamins A, E, K and dihydrovitamin K) were measured using GC or HPLC. Presented are results of pooled group analysis between change in age and sex standardized BMIz and dietary/endogenous metabolism biomarkers. Using multivariate logistic regression (odds ratios [95% confidence intervals]), MUFA 16:1n-7 (0.26 [0.07-0.98]), an indicator of de novo lipogenesis, was negatively associated with, while 18:1n-9trans (13.5 [1.5-128.1]), a biomarker of partially-hydrogenated fat, and lycopene (1.02 [1.01-1.05]), a biomarker for tomato-based foods, were positively associated with change in BMIz. Delta-6-desaturase (D6D; 20:3n-6/18:2n-6) and delta-5-desaturase (D5D; 20:4n-6/20:3n-6) activities, indicators of endogenous fatty acid metabolism, were negatively (0.32 [0.15-0.68]) and positively (1.10 [1.01-1.22]) associated with change in BMIz, respectively. Results suggest that foods high in partially-hydrogenated fat and tomato-based products (e.g., pizza) have an adverse effect on change in BMIz. Additionally, the changes in D6D and D5D indices suggest that in vivo metabolism is predictive of change in BMIz in this cohort of high-risk children.
Abstract 1552: CCN5/wisp-2 induced growth arrest of aggressive triple negative breast cancer cells is promoted through accumulation and trafficking of p27kip1
Authors: Inamul Haque, Snigdha Banerjee, Archana De, Gargi Maity, Sandipto Sarkar, Douglas McGragor, Sushanta K. Banerjee
Journal: Cancer Research (2014)

Abstract CCN5, a matricellular protein, represents promising treatment target in triple negative breast cancer (TNBC) as treatment or induced activation of CCN5 in TNBC cells promotes cell growth arrest at G0/G1 phase, reduces cell proliferation and delays tumor growth in xenograft model. Our studies found that p27Kip1 tumor suppressor protein is upregulated and relocalized to the nucleus from cytoplasm by CCN5 in these cells and that these two events (i.e., upregulation and relocalization) of p27Kip1 is required for CCN5-induced growth inhibition of TNBC cells. In the absence of CCN5, p27Kip1 remains mostly in the cytoplasm, a state of aggressive nature of cancer cells. Mechanistically, CCN5 inhibits Skp2 expression, which seems to stabilize p27Kip1 protein in these cells. On the other hand, CCN5 also recruits FOXO3a to mediate transcriptional regulation of p27Kip1. The recruitment of FOXO3a is achieved by the induction of its expression and activity through shifting from cytoplasm to the nucleus. Our data indicate that CCN5 blocks PI3K/AKT signaling to dephosphorylate at S318, S253 and Thr32 in FOXO3a for nuclear relocalization and activation of FOXO3a. Inhibition of α6β1 diminishes CCN5 action on p27Kip1 in TNBC cells. Collectively, CCN5 may have therapeutic potential for TNBC. Citation Format: Inamul Haque, Snigdha Banerjee, Archana De, Gargi Maity, Sandipto Sarkar, Douglas McGragor, Sushanta K. Banerjee. CCN5/wisp-2 induced growth arrest of aggressive triple negative breast cancer cells is promoted through accumulation and trafficking of p27kip1 . [abstract]. In: Proceedings of the 105th Annual Meeting of the American Association for Cancer Research; 2014 Apr 5-9; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2014;74(19 Suppl):Abstract nr 1552. doi:10.1158/1538-7445.AM2014-1552
Abstract 2672: Vinyl sulfone analogues of lysophosphatidylcholine irreversibly inhibit autotaxin and prevent angiogenesis in melanoma
Authors: Mandi M. Murph, Molly Altman, Wei Jia, Duy Nguyen, Jada Fambrough, William J. Hardman, Guowei Jiang, Damian Madan, Jianxing Zhang, Glenn D. Prestwich
Journal: Cancer Research (2014)

Abstract Autotaxin (ATX) is an enzyme discovered in the conditioned medium of cultured melanoma cells and identified as a protein that strongly stimulates motility. This unique ectonucleotide pyrophosphatase and phosphodiesterase facilitates the removal of a choline headgroup from lysophosphatidylcholine (LPC) to yield lysophosphatidic acid (LPA), which is a potent lipid stimulator of tumorigenesis. Thus, ATX has received renewed attention because it has a prominent role in malignant progression and represents a promising area of research with significant translational potential. Since ATX inhibitors may have broad implications for therapy, we sought to create a novel series of inhibitors for use against cancer, especially melanoma. Herein we report on the synthesis and biological activity of a targeted affinity label for the active site of ATX, which has a critical threonine residue that acts as a nucleophile in the lysophospholipase D reaction to liberate choline. We synthesized a set of vinyl sulfone analogs of ATX that function as irreversible inhibitors of ATX and inactivate the enzyme. We commenced biological testing of this compound with viability assays against multiple cancer cell lines whereby the IC50 values ranged from 6.74 - 0.39 μM, which was consistent with the Ki of the vinyl sulfone (3.50 μM). In addition, this compound was also able to significantly inhibit melanoma cell wound closure and pore migration. Most importantly, the vinyl sulfone significantly inhibited melanoma progression using an in vivo tumor model by preventing angiogenesis. Taken together, this suggests that the vinyl sulfone is a potent and irreversible ATX inhibitor with significant biological activity both in vitro and in vivo. Note: This abstract was not presented at the meeting. Citation Format: Mandi M. Murph, Molly Altman, Wei Jia, Duy Nguyen, Jada Fambrough, William J. Hardman, Guowei Jiang, Damian Madan, Jianxing Zhang, Glenn D. Prestwich. Vinyl sulfone analogues of lysophosphatidylcholine irreversibly inhibit autotaxin and prevent angiogenesis in melanoma. [abstract]. In: Proceedings of the 105th Annual Meeting of the American Association for Cancer Research; 2014 Apr 5-9; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2014;74(19 Suppl):Abstract nr 2672. doi:10.1158/1538-7445.AM2014-2672
Nostalgia: In praise of on call?
Authors: C. Gunstone
Journal: BMJ (1998)

My not too long retired senior partners can recall clashing forceps and chloroform in the back streets of Burton. As I am gently eased out of time consuming obstetric care I sense a vague feeling of disquiet.

I have spent this bank holiday on call. I have been working in an urban 10 000 patient practice for the past 10 years. During the 24 hours I saw 16 patients—a few more …
AIDS: Etiology, Diagnosis, Treatment, and Prevention.
Authors: Vincent T. DeVita, Samuel Hellman, Steven A. Rosenberg
Journal: Annals of Internal Medicine (1985)

This book presents the latest information from leading authorities involved in ongoing AIDS research and developments. Featured in this new edition are chapters on the laboratory diagnosis of the HIV infection; TB and other bacterial infections; cytomegaloviruses and other infections; Kaposi's sarcoma in AIDS; neurological manifestation in the HIV infected patient; counselling of the HIV-infected individual, their families and partners; and risk exposure to the health care worker.
High expression of tissue inhibitors of metalloproteinase-2 (TIMP-2) in serous ovarian carcinomas and its role in ovarian tumorigenesis
Authors: Byoung-Gie Kim, Tae-Joong Kim, Chel Hun Choi, Jeong-Won Lee, Duk-Soo Bae, Je-Ho Lee, Seung Bae Rho, Yoon-La Choi
Journal: Cancer Research (2006)

Proc Amer Assoc Cancer Res, Volume 47, 2006

4508 

Tissue inhibitors of metalloproteinases (TIMPs) play a key role in maintaining homeostasis of the extracellular matrix (ECM) by controlling matrix metalloproteinases (MMPs). In addition to their role in regulating MMPs, TIMPs have been shown to also have pluripotential effects on cell growth, apoptosis and differentiation. The aim of this study was to examine TIMP-2 level in serous ovarian tumor tissues and to further understand the role of TIMP-2 protein in ovarian tumorigenesis. In a total of 57 ovarian specimens including 5 normal ovaries, 12 benign serous cystadenomas, 20 serous borderline tumors and 20 serous carcinomas, expression of TIMP-2 was assessed by immunohistochemical staining. In order to understand the effect of TIMP-2 overexpression in cell lines, we performed an apoptosis assay as well as a MTT assay by transfecting TIMP-2 vector into SKOV3, 2774 and HeLa cell lines. The study results demonstrated that immunohistochemical staining of TIMP-2 was observed to be significantly more frequent in serous carcinomas when compared to the other groups. A transient overexpression of TIMP-2 caused dramatic reduction of cell growth and a change in cell morphology only in HeLa cells, not in 2774 or SKOV3 cells. These results demonstrate that TIMP-2 is up-regulated in serous ovarian carcinoma tissues when compared to normal ovarian tissues; it dose not mediate pro-apoptotic activity in ovarian cancer cell lines, however, it does mediate pro-apoptotic activity in cervical cancer cells. These findings suggest that TIMP-2 may function in favor of tumor growth in serous ovarian tumorigenesis. Additional research is now needed to further elucidate the role of TIMP-2 in the biological behavior of ovarian serous carcinoma.
Abstract 17474: The Morphological Change of Left Ventricular Outflow Tract by Aging
Authors: Tai Sekine, Takatsugu Kajiyama, Yusuke Hyodo, Norimasa Tonoike, Kyokushi Hou, Yuji Matsudo, Yoshihide Fujimoto, Masashi Yamamoto, Toshiharu Himi
Journal: Circulation (2010)

Background: The Area of left ventricular outflow tract (LVOT) is now calculated with LVOT diameter on the assumption that it's shape is a circle. The latest development of three dimensional echocardiography (3DE) can visualize LVOT directly. The morphological change of LVOT by aging is not clear. Methods: we evaluated 50 cases (mean age 61 years, 24 male ) which have normal left ventricular ejection fraction with transthoracic echocardiography. We recorded conventional left ventricular morphology with two dimensional echocardiography and recorded 3DE of parasternal long axis view and analyzed LVOT area (LVOT-A) and long (D1) and short axis (D2) of LVOT diameter at end diastole. Results: LVOT showed elliptical shape and LVOT-A obtained with 3DE was larger than the LVOT-A calculated with LVOT diameter (3.9±0.6cm2 v.s.3.1±0.6cm2;p<0.01). We divided these study population into 2 groups according with age. GroupIwas composed with less than 60 years (mean age 45 years n=21), GroupII was more than 60 years ( mea...
Dyke's Automobile and Gasoline Engine Encyclopedia: The Elementary Principles, Construction, Operation and Repair of Automobiles, Gasoline Engines and Automobile Electric Systems; Including Trucks, Tractors, Motorcoaches, Automotive Diesel Engines, Aircraft Engines and Motorcycles. Simple, Thorough and Practical
Authors: Dyke, A. L. , b.
Journal: JAMA (1941)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Journals JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2024 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The Necessity of Nurses
Authors: Tracy Hampton
Journal: JAMA (2004)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Cytological and Immunocytochemical Features of Merkel Cell Carcinoma on Fine Needle Cytology Samples: A Study of 22 Cases
Authors: Anna Cipolletta Campanile, Maria Gabriella Malzone, Veronica Sanna, Jessica Barizzi, Angela Manna, Antonella Gioioso, Annarosaria De Chiara, Franco Fulciniti
Journal: Endocrine Pathology (2015)
Abstract 3052: Genomic, transcriptomic, and epigenomic analyses of gastric cancer stem cells
Authors: Seon-Young Kim, Su-Jin Baek, Myoung-Eun Han, Hee-Jin Kim, Jeong-Hwan Kim, Sae-Ock Oh
Journal: Cancer Research (2014)

Abstract Cancer stem cells are a small population of tumor cells with self-renewal and differentiation capacity, and have been isolated from many types of cancers including stomach. However, the molecular mechanisms underlying the self-renewal and tumorigenic potential of cancer stem cells are poorly understood. To understand the molecular characteristics of gastric cancer stem cells (GCSC), we performed five kinds of experiments including genomic (Exome-seq and Affymetrix SNP 6.0 array), transcriptomic (RNA-seq and small RNA-seq), and epigenomic (MBD-seq) analyses on GCSC, non-gastric cancer stem cells (non-GCSC), and normal tissues from three gastric cancer patients. Among the five data sets, miRNA changes were most significant between GCSC and non-GCSC showing that 39.4% of miRNAs were down-regulated and 1.25% of miRNAs were up-regulated in GCSC compared with non-GCSC. In RNA-seq, 217 (0.93%) genes were up-regulated while 470 (2.02%) genes were down-regulated. Gene-set analysis revealed that development-associated biological processes such as epidermis development and ectoderm development were most enriched terms. In MBD-seq, there were 2.80% of hypermethylated and 2.38% of hypomethylated genes in GCSC compared with non-GCSC. Detailed lists of genes, gene-sets and biological pathways that distinguish GCSC from non-GCSC will be presented and discussed. Citation Format: Seon-Young Kim, Su-Jin Baek, Myoung-Eun Han, Hee-Jin Kim, Jeong-Hwan Kim, Sae-Ock Oh. Genomic, transcriptomic, and epigenomic analyses of gastric cancer stem cells. [abstract]. In: Proceedings of the 105th Annual Meeting of the American Association for Cancer Research; 2014 Apr 5-9; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2014;74(19 Suppl):Abstract nr 3052. doi:10.1158/1538-7445.AM2014-3052
ABC of hypertension: Blood pressure measurement
Authors: E. O'Brien
Journal: BMJ (2001)

It has been recognised for over 50 years that blood pressure measured in the home is lower than that recorded by a doctor.1 The discrepancy between pressures recorded in the home and the clinic has been confirmed repeatedly, and is present regardless of whether patients, or their relatives or friends, measure blood pressure.2



A selection of automated devices



Why then has home measurement of blood pressure failed to achieve the success and popularity of home urinalysis in diabetes? There are a number of explanations: training patients to measure their own blood pressures using the auscultatory technique was troublesome and time consuming and not suitable for many subjects; the technique is subject to bias whereby some patients record pressures of their own making; doctors often perceive the technique as one which induces anxiety or causes the patient to take an obsessional interest in blood pressure; most automated devices available for self measurement had not been validated adequately, or had been shown to be inaccurate; finally, because the technique was little used data have been lacking to provide the evidence needed to assure its place in modern clinical practice.

For these reasons home measurement of blood pressure has not received widespread acceptance in medical practice, although its popularity with patients is considerable. However, the advent of accurate inexpensive automated devices which can provide a printout of blood pressure measurement with the time and date of measurement, or which allow storage of data for later analysis, plotting and/or electronic transmission of data, has removed many of the drawbacks referred to above, and there is now a renewed interest in self blood pressure measurement. This revival of interest in an old methodology was recognised when experts from around the world gathered at the First International Consensus Conference on Self-Blood Pressure Measurement (SBPM) …
Don’t forget mediastinal masses
Authors: Matthew J Murray, James C Nicholson, Donna McShane
Journal: BMJ (2008)

O’Carroll et al highlight some of the important issues in childhood asthma unresponsive to simple treatment in primary care.1 However, they omit malignancy from their differential diagnoses, missing an essential learning point—that chest radiography is advised in children failing to respond to simple standard asthma treatment and certainly before starting oral steroids. …
Nonmulberry Silk Fibroin Scaffold Shows Superior Osteoconductivity Than Mulberry Silk Fibroin in Calvarial Bone Regeneration
Authors: Neety Sahu, Prakash Baligar, Swati Midha, Banani Kundu, Maumita Bhattacharjee, Snehasish Mukherjee, Souhrid Mukherjee, Florian Maushart, Sanskrita Das, Marko Loparic, Subhas C. Kundu, Sourabh Ghosh, Asok Mukhopadhyay
Journal: Advanced Healthcare Materials (2015)

Recent years have witnessed the advancement of silk biomaterials in bone tissue engineering, although clinical application of the same is still in its infancy. In this study, the potential of pure nonmulberry Antheraea mylitta (Am) fibroin scaffold, without preloading with bone precursor cells, to repair calvarial bone defect in a rat model is explored and compared with its mulberry counterpart Bombyx mori (Bm) silk fibroin. After 3 months of implantation, Am scaffold culminates in a completely ossified regeneration with a progressive increase in mineralization at the implanted site. On the other hand, the Bm scaffold fails to repair the damaged bone, presumably due to its low osteoconductivity and early degradation. The deposition of bone matrix on scaffolds is evaluated by scanning electron and atomic force microscopy. These results are corroborated by in vitro studies of enzymatic degradation, colony formation, and secondary conformational features of the scaffold materials. The greater biocompatibility and mineralization in pure nonmulberry fibroin scaffolds warrants the use of these scaffolds as an “ideal bone graft” biomaterial for effective repair of critical size defects.
Parliamentary committee on abortion fails to agree
Authors: Doug Payne
Journal: BMJ (2000)

A 12 person parliamentary committee, set up last year to consider the Irish government's green paper on abortion, has failed to agree on any definitive course of action.

After reviewing 100 000 submissions, the committee issued a 700 page report outlining three possible options.

The first is, in essence, no change to current legislation. After a 1992 Supreme Court decision, abortion is permissible where there is a real and substantial risk to the life, as distinct from the health, of …
Problematic Internet use: is it more compulsory than rewarding or mood driven?
Authors: STEFANO PALLANTI
Journal: World Psychiatry (2010)

Internet represents the most important product of cultural industry in the mass society, and at the same time the ultimate threatening to the intimate space of subjectivity. Nonetheless, for most of us, it is just an unavoidable part of daily rituality. A few years ago, L. Wittgenstein stated that newspaper reading has replaced the morning prayer in the modern age. Today we could state that the laptop screen has replaced the tabernacle. Nowadays Internet dysfunctional use is a true concern. In a sample of Italian students 1, we found that 5.6% were addicted to Internet according to the Internet Addiction Scale, and more than 15%, when interviewed by the PROMIS Questionnaire, reported they were disturbed by compulsive submissive or dominant repetitive behavior (including Internet chatting and mobile phone messaging). All these compulsions were strongly related to substance addiction, such as alcohol or drug use. The distinction between physiological and pathological use of electronic media is, socially, a matter of quantity of time consumed and related social impairment. From the subjective viewpoint, the first signs are the psychological changes occurring in the virtual world (online disinhibition and increased risk-taking behaviors), along with the occurrence of dissociative experiences up to “loss of control”. In a recent study 2, we found that the severity measures of Internet addiction were positively correlated with perceived impairment of functioning in the family context (r = 0.814; p≤0.001) and Yale-Brown Obsessive Compulsive severity score (r = 0.771; p≤0.001). Scores on the Dissociative Experience Scale were higher than expected (23.2±1.8) and were related to higher obsessive compulsive scores (r = 0.618; p≤0.001), increased hours per week on the Internet (r = 0.749; p≤0.001), and a higher perceived impairment of functioning in the family context (r = 0.677; p≤0.001). From a phenomenological point of view, Internet addiction in our sample seemed to be more compulsory than rewarding or mood driven. The main attractiveness of Internet appeared to be emotional detachment. It remains unclear whether Internet problematic use should be included among impulse control or addictive disorders. It will be useful in this respect to investigate the brain mechanisms and candidate endophenotypes (especially the number of D2 receptors in the mesocorticolimbic system and their downregulation after stimulation of the system). This could help us to develop effective strategies to prevent and treat the disorder both pharmacologically and behaviourally.