OBSERVATIONS ON ERYTHROPOIETIC-STIMULATING FACTOR (ESF) IN THE PLASMA OF UREMIC AND NONUREMIC ANEMIC PATIENTS
Authors: N I GALLAGHER, J M McCARTHY, R D LANGE
Journal: Annals of Internal Medicine (1960)

Article1 June 1960OBSERVATIONS ON ERYTHROPOIETIC-STIMULATING FACTOR (ESF) IN THE PLASMA OF UREMIC AND NONUREMIC ANEMIC PATIENTSN. I. GALLAGHER, M.D., J. M. MCCARTHY, M.D., R. D. LANGE, M.D., F.A.C.P.N. I. GALLAGHER, M.D.Search for more papers by this author, J. M. MCCARTHY, M.D.Search for more papers by this author, R. D. LANGE, M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-52-6-1201 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptDuring the last decade the clinical and experimental observations of numerous investigators have established the concept that erythropoiesis is regulated in part by humoral factors. Recent extensive reports1-6indicate the present interest in this subject; nonetheless, select areas are unexplored, while others remain controversial. The part played by disturbances of the humoral regulatory mechanism in the pathogenesis of anemia is essentially unknown and the existence of single or multiple factors is debated.7-10Likewise, the site of production of the regulatory factor(s) is not clear. Jacobson's11-14experiments point to the kidney as the source or activator of the humoral factor(s). Other...Bibliography1. GrantRoot WCWS: Fundamental stimulus for erythropoiesis, Physiol. Rev. 32: 449, 1952. CrossrefMedlineGoogle Scholar2. JacobsonGoldwasser LOE: The dynamic equilibrium of erythropoiesis, Brookhaven Sympos. Biol. 10: 110, 1957. Google Scholar3. Gordon AS: Hematopoietine, Physiol. Rev. 39: 1, 1959. CrossrefMedlineGoogle Scholar4. BrecherStohlman GF: Humoral factors in erythropoiesis, Progress in Hematology 2: 110, 1959. Google Scholar5. GordonRoot ASWS, Editors: Hematopoietic mechanisms, Ann. New York Acad. Sc. 77: 407, 1959. Google Scholar6. 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Erythropoietin in human plasma, J. Lab. and Clin. Med. 50: 534, 1957. MedlineGoogle Scholar44. StohlmanBrecher FG: Humoral regulation of erythropoiesis. V. Relationship of plasma erythropoietine level to bone marrow activity, Proc. Soc. Exper. Biol. and Med. 100: 40, 1959. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: *Received for publication March 7, 1960.Presented in part at the Fortieth Annual Session of The American College of Physicians, Chicago, Illinois, April 20, 1959.From the St. Louis Veterans Administration Hospital and the Departments of Medicine, St. Louis University and Washington University, St. Louis, Missouri.†Work supported in part by U. S. Public Health Service Grant No. H-2793.Requests for reprints should be addressed to N. I. Gallagher, M.D., Veterans Administration Hospital, 915 North Grand Boulevard, St. Louis 6, Missouri. 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