tbuckley/cabot-search huggingface dataset:
Allergic rhinitis in children
Authors: Thomas Sanford
Journal: BMJ (2014)

Allergic rhinitis (AR) is common in children. The prevalence has been reported to be 20-40% in the pediatric population worldwide. The cause and risk factors for the development of AR are incompletely defined but involve both genetic and environmental elements. Although allergic rhinitis is seldom a severe or life threatening disease, it can have profound effects on daily living and development of a child. AR has multiple comorbidities and is closely related to asthma and atopic dermatitis. Often the child's parents will concentrate on comorbid diseases only and will not mention or be concerned by symptoms of their child's allergic rhinitis. Diagnosis of AR is made by a combination of history and physical exam. The causative allergens are identified by allergy testing. Allergy testing is done in vivo (skin testing) or in vitro (Rast testing). Treatment ofAR can include allergen avoidance, pharmacotherapy and immunotherapy. All three therapies are effective and safe in children.
955. Bystander Activity of Ad-mda7: MDA-7 Protein Kills Melanoma Cells Via a Receptor-Dependent but STAT3-Independent Mechanism
Authors: Sunil Chada, Abner Mhashilkar, Rajagopal Ramesh, John B. Mumm, Dora Bocangel, Elizabeth A. Grimm, Suhendan Ekmekcioglu
Journal: Molecular Therapy (2004)
Clonal analyses and gene profiling identify genetic biomarkers of the thermogenic potential of human brown and white preadipocytes
Authors: Ruidan Xue, Matthew D Lynes, Jonathan M Dreyfuss, Farnaz Shamsi, Tim J Schulz, Hongbin Zhang, Tian Lian Huang, Kristy L Townsend, Yiming Li, Hirokazu Takahashi, Lauren S Weiner, Andrew P White, Maureen S Lynes, Lee L Rubin, Laurie J Goodyear, Aaron M Cypess, Yu-Hua Tseng
Journal: Nature Medicine (2015)
The role of humor and folklore themes in psychotherapy
Authors: J E Heuscher
Journal: American Journal of Psychiatry (1980)

In the alternation of deconstitution and constitution that is fundamental to human life, humor has a useful role, mainly as a deconstituting force, whereas folklore emphasizes the revitalization of existence. Yet humor can be harmful in situations where there is a lack of mutual respect, and it can be growth-retarding if it becomes a substitute for needed change. The effectiveness of humor and folklore themes is proportional to the genuineness of the interpersonal relationship. In folklore, humor reinforces the injunction to seek wider worlds beyond the one that has become monotonous and stifling. Humor and folklore themes can, therefore, prove helpful when used judiciously in psychotherapy.
Technology and Technique Standards for Camera-Acquired Digital Dermatologic Images
Authors: Elizabeth A. Quigley, Barbara A. Tokay, Sarah T. Jewell, Michael A. Marchetti, Allan C. Halpern
Journal: JAMA Dermatology (2015)

Photographs are invaluable dermatologic diagnostic, management, research, teaching, and documentation tools. Digital Imaging and Communications in Medicine (DICOM) standards exist for many types of digital medical images, but there are no DICOM standards for camera-acquired dermatologic images to date.To identify and describe existing or proposed technology and technique standards for camera-acquired dermatologic images in the scientific literature.Systematic searches of the PubMed, EMBASE, and Cochrane databases were performed in January 2013 using photography and digital imaging, standardization, and medical specialty and medical illustration search terms and augmented by a gray literature search of 14 websites using Google. Two reviewers independently screened titles of 7371 unique publications, followed by 3 sequential full-text reviews, leading to the selection of 49 publications with the most recent (1985-2013) or detailed description of technology or technique standards related to the acquisition or use of images of skin disease (or related conditions).No universally accepted existing technology or technique standards for camera-based digital images in dermatology were identified. Recommendations are summarized for technology imaging standards, including spatial resolution, color resolution, reproduction (magnification) ratios, postacquisition image processing, color calibration, compression, output, archiving and storage, and security during storage and transmission. Recommendations are also summarized for technique imaging standards, including environmental conditions (lighting, background, and camera position), patient pose and standard view sets, and patient consent, privacy, and confidentiality. Proposed standards for specific-use cases in total body photography, teledermatology, and dermoscopy are described.The literature is replete with descriptions of obtaining photographs of skin disease, but universal imaging standards have not been developed, validated, and adopted to date. Dermatologic imaging is evolving without defined standards for camera-acquired images, leading to variable image quality and limited exchangeability. The development and adoption of universal technology and technique standards may first emerge in scenarios when image use is most associated with a defined clinical benefit.
Metabolism of Neoplastic Tissue. XV. Oxidation of Exogenous Fatty Acids in Lettré-Ehrlich Ascites Tumor Cells&lt;xref ref-type="fn" rid="FN1"&gt;2&lt;/xref&gt;
Authors: Grace Medes, Alice J. Thomas, Sidney Weinhouse
Journal: JNCI Journal of the National Cancer Institute (1960)

Lettré-Ehrlich ascites tumor cells were incubated in vitro in a phosphate saline medium with palmitate-1-C14, and its oxidation was measured by following the incorporation of radioactivity in respiratory CO2. Regardless of whether the labeled fatty acid was present as plasma lipide, free palmitate, or as the serum-protein complex, it was oxidized readily at slightly less than linear rates over periods up to 4 hours. Oxidation of the 3 forms was greatly depressed by glucose, to a lesser extent by galactose, and only slightly by lactate and acetate. The data indicate that fatty acids are major substrates for tumor respiration, but their oxidation is partially spared when glucose is present in adequate concentration. These findings amplify and confirm previous conclusions based on studies of endogenous fatty-acid oxidation.
Abstract 10291: An Active Targeting Drug Delivery System, a Nano-Size Liposome with Sialyl Lewis X, is a Promising Protective Tool against Ischemia Reperfusion Injury
Authors: Yoshihisa Yamada, Hiroyuki Kobayashi, Masamitsu Iwasa, Shohei Sumi, Hiroaki Ushikoshi, Takuma Aoyama, Kazuhiko Nishigaki, Genzou Takemura, Takako Fujiwara, Hisayoshi Fujiwara, Shinya Minatoguchi
Journal: Circulation (2010)

Purpose: It has been reported that erythropoietin(EPO) prevents cardiac remodeling and improves cardiac function via activation of prosurvival signals and angiogenesis. However, an effective dose o...
PORPHYKIA CUTANEA TARDA FOLLOWING JAUNDICE..
Authors: L. G. TULLOCH, K. P. Warin
Journal: British Journal of Dermatology (1957)

Journal Article PORPHYKIA CUTANEA TARDA FOLLOWING JAUNDICE.: Report of Two Cases. Get access L. G. TULLOCH, M.D., L. G. TULLOCH, M.D. United Bristol Bristol Hospitals Search for other works by this author on: Oxford Academic Google Scholar K. P. Warin, M.D., M.R.C.P. K. P. Warin, M.D., M.R.C.P. United Bristol Bristol Hospitals Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 69, Issue 3, 1 March 1957, Pages 82–85, https://doi.org/10.1111/j.1365-2133.1957.tb13233.x Published: 01 March 1957
New global Health for All targets
Authors: L. M van Herten, H. P A van de Water
Journal: BMJ (1999)

In May 1998, the World Health Organisation adopted a resolution in support of the new global Health for All policy.1 The new policy, Health for All in the 21st Century,2 succeeds the Health for All by the Year 2000 strategy launched in 1977.3 The renewal of Health for All, concurrent with the 50th anniversary of the WHO and the appointment of a new director general, offers a unique opportunity for the organisation to re-establish its purpose. In the new policy, the worldwide call for social justice is elaborated in key values, goals, objectives, and targets. The 10 global health targets are the most concrete end points to be pursued. They can be divided into three subgroups (see box)—four health outcome targets, two targets on determinants of health, and four targets on health policies and sustainable health systems. All member states are supposed to set their own targets within this framework, based on their specific needs and priorities.

Presenting the new policy at the World Health Assembly was the first step in the renewal of the Health for All movement. The development of indicators for some of the targets and the promotion of the Health for All policy in all member states formed the next steps in the process.4 There are two main aims behind the Health for All in the 21st Century programme. Firstly, the WHO wants to develop a shared vision by listing the 10 most important health issues. Secondly, the organisation wants to formulate 10 targets to motivate all member states to take action and to set priorities for resource allocation. To fulfil these aims the WHO sought to include in the new targets components that were inspirational and achievable.

#### Summary points

The renewal of the Health for All strategy represents a further call for social …
Tumor–host interactions in the gallbladder suppress distal angiogenesis and tumor growth: Involvement of transforming growth factor β1
Authors: Takeshi Gohongi, Dai Fukumura, Yves Boucher, Chae-Ok Yun, Gerald A. Soff, Carolyn Compton, Takeshi Todoroki, Rakesh K. Jain
Journal: Nature Medicine (1999)
195. Therapeutic Angiogenesis in Mouse Ischemic Heart after Intramyocardial Injection of a Novel Two Gene Plasmid Vector Co-Expressing High Levels of Human VEGF and bFGF Genes
Authors: Phoebe Luo, Kengo Kusano, Tom Tsang, David Harris, Douglas Losordo
Journal: Molecular Therapy (2004)

Therapeutic angiogenesis has been shown a great promise to treat ischemic cardiovascular diseases. Many growth factor cytokines with angiogenic activity have been investigated for such purpose. Vascular endothelial growth factor (VEGF) and fibroblast growth factor (FGF) are the two best studied angiogenic cytokines in treating ischemic cardiovascular diseases both in animal models and clinical trials. And synergistic effect in therapeutic angiogenesis from using VEGF and bFGF either as recombinant proteins or genes has been reported by several groups. In the context of cardiovascular gene therapy, development of gene therapy vehicles capable of delivering multiple genes is desired. In this study, two angiogenic cytokine genes, human VEGF165 and bFGF, were incorporated into a multiple-gene expression plasmid vector, p2-MCS. Instead of using the viral-derived IRES, we employed independent transcriptional units to drive these two genes, respectively. In vitro transient transfections, our data showed that p2-VEGF-FGF vector was capable of co-expressing high levels of both hVEGF and bFGF genes simultaneously. The expression levels of both genes from the p2-hVEGF-FGF vector were comparable to that achieved by using vectors carrying either VEGF or bFGF gene alone. Using mouse ischemic heart model, the efficacy of therapeutic angiogenesis after intramyocardial injection with p2-VEGF-FGF vector is investigated and compared to that achieved from injection with vectors carrying either of the two genes alone.
Abstract 4547: Enhanced anti-tumor effect of WNT pathway antagonists in combination with taxanes
Authors: Wan-Ching Yen, Marcus M. Fischer, John Lewicki, Austin Gurney, Timothy Hoey
Journal: Cancer Research (2014)

Abstract The Wnt/beta-catenin pathway, which signals through the Frizzled (FZD) receptor family and several co-receptors, has long been implicated in cancer. We have previously demonstrated that inhibition of WNT/beta-catenin signaling by vantictumab (anti-FZD) or OMP-54F28 (FZD8-Fc) inhibits tumor growth, decreases tumorigenicity and induces differentiation in solid tumors. The anti-tumor effect of our Wnt antagonists is most evident in combination with chemotherapeutic agents. We sought to determine if the anti-tumor effect of Wnt pathway inhibitors varied with different chemotherapeutic agents. We compared the growth inhibitory effect of vantictumab and OMP-54F28 with either taxanes (paclitaxel and nab-paclitaxel) or with DNA synthesis inhibitors (gemcitabine and carboplatin) in patient-derived tumor xenografts. In a model for pancreatic ductal carcinoma, vantictumab with nab-paclitaxel was more efficacious than vantictumab with gemcitabine in inhibiting tumor growth and Wnt target gene expression (at doses of nab-paclitaxel and gemcitabine that were equivalent in their single-agent growth-inhibitory effects). Histologic analysis indicated that nab-paclitaxel increased mitotic cells and beta-catenin levels. Importantly, the addition of vantictumab to nab-paclitaxel reversed the nab-paclitaxel-induced increase in mitotic cells and beta-catenin expression. An independent experiment in a serous ovarian cancer xenograft model also showed enhanced anti-tumor activity when combining OMP-54F28 with either paclitaxel or nab-paclitaxel compared to the combination with carboplatin. A potential mechanism to account for these results involves on the observation that Wnt/beta-catenin signaling is under cell cycle control and peaks at the G2/M phase. Taxanes inhibit microtubule function and block the cell cycle at G2/M. In contrast, other chemotherapeutic agents, such as platinum compounds and nucleoside analogs, inhibit DNA synthesis and block cell proliferation at S phase. We hypothesize that combination of Wnt blockade with chemotherapeutic agents, such as taxanes, that induce G2/M arrest may result in optimal anti-tumor activity. Citation Format: Wan-Ching Yen, Marcus M. Fischer, John Lewicki, Austin Gurney, Timothy Hoey. Enhanced anti-tumor effect of WNT pathway antagonists in combination with taxanes. [abstract]. In: Proceedings of the 105th Annual Meeting of the American Association for Cancer Research; 2014 Apr 5-9; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2014;74(19 Suppl):Abstract nr 4547. doi:10.1158/1538-7445.AM2014-4547
Detection of circulating tumor cells in peripheral blood of patients with metastatic breast cancer - A multi-center validation study of the CellSearch™ system.
Authors: Sabine Riethdorf, Volkmar Müller, Cornelia Coith, Katrin Baack, Fritz Jänicke, Herbert A. Fritsche, Summer Jackson, Terry Gornet, Klaus Pantel
Journal: Cancer Research (2006)

5146   Background: The CellSearch ™  system (Veridex) is able to enrich circulating tumor cells (CTC) and to provide clinical relevant information. The aim of this multi-center study was to validate the analytical performance of the CellSearch ™  system for clinical routine use in patients with metastatic breast cancer. Material and Methods: This prospective study involved samples from both normal individuals and patients with metastatic breast cancer. CTC were identified as nucleated cells expressing cytokeratins, but lacking CD45 expression. The following analytical and clinical parameters were tested: intra- and inter-assay variability using positive controls containing defined numbers of high (average 1000) and low (average 50) control cells, cell stability based on varying storage time and temperature, recovery precision of spiked samples from 1000 cells to 5 cells, and incidence of CTC in samples from patients with metastatic breast cancer. Results: The intra-assay precision for both sites was high: All 8 positive controls analyzed in the same run were within the specified range. The inter-assay precision was also high: >90% of control values (n=100) were within the specified range. Recovery in spiking experiments ranged from 70-100% at the 4 to 12 cell level for both sites. None of the control subjects had CTC. Recovery rate was found to be more dependent on storage temperature with improved results for room temperature versus 4°C than by time of storage. For stability testing, samples were categorized into those with either  ™  system enables the reliable detection of CTC in whole blood of metastatic breast cancer patients. Combined with previous clinical reports, the system appears to be a suitable tool for the routine assessment of metastatic breast cancer patients. Blood samples should be shipped at room temperature and CTC counts are stable for at least 72 hours. These results can be the basis for the clinical implementation of this system.
Abstract 3084: Bare Metal Stenting versus Percutaneous Pulmonary Valve Implantation for Treatment of Right Ventricular Outflow Tract Obstruction - Utilization of a Catheter/Magnetic Resonance Hybrid Lab for Acute Physiological Comparison
Authors: Philipp Lurz, Johannes Nordmeyer, Sachin Khambadkone, Graham Derrick, Rob Yates, Vivek Muthurangu, Rod Jones, Philipp Bonhoeffer, Andrew M Taylor
Journal: Circulation (2008)

Background: Treatment of right ventricular outflow tract obstruction (RVOTO) is possible with a bare metal stent (BMS), though this causes pulmonary regurgitation (PR). In this study, we sought to assess the acute physiological effects of BMS vs. percutaneous pulmonary valve implantation (PPVI) using a catheter/ magnetic resonance (MR) hybrid lab (Siemens). Methods: 12 consecutive children (median age 12.9) with significant RVOTO (echo gradient &gt; 50 mmHg) were included. Patients were initially placed in the MR scanner and the ventricular volumes and great vessel blood flow assessed under general anaesthetic (GA). Patients were then transferred into the bi-plane catheter lab (under the same GA, on a sliding table) and a BMS inserted. Catheters and wires were removed and patients were transferred back to MR for repeat assessment. This whole process was repeated for a PPVI, which was placed into the BMS. MR and pressure data were compared with repeated measures ANOVA and post-hoc testing between the 3 physiological states. Results (see Table ): BMS placement significantly reduced RV pressures and caused free PR. The increased PR was partially compensated for by a decrease in RV ESV and an increase in RV EF. There was no improvement in effective RV SV after BMS placement. Re-valvulation with PPVI resulted in a significant increase in effective RV SV, with consequent heart rate reduction at maintained cardiac output. Conclusion: Utilisation of a catheter/MR hybrid lab offers new opportunities for the assessment of acute physiology following percutaneous interventions. Using this method we have demonstrated the superior acute haemodynamic effects of PPVI over BMS in patients with RVOTO.
Augmented-Reality–Assisted Laparoscopic Adrenalectomy
Authors: Jacques Marescaux, Francesco Rubino, Mara Arenas, Didier Mutter, Luc Soler
Journal: JAMA (2004)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Variation of Interstitial Glucose Measurements Assessed by Continuous Glucose Monitors in Healthy, Nondiabetic Individuals
Journal: Diabetes Care (2010)

OBJECTIVE To characterize glucose levels during daily living using continuous glucose monitors (CGMs) in nondiabetic individuals. RESEARCH DESIGN AND METHODS Seventy-four healthy children, adolescents, and adults aged 9–65 years with normal glucose tolerance used a blinded CGM device for 3 to 7 days. RESULTS Sensor glucose concentrations were 71–120 mg/dl for 91% of the day. Sensor values were ≤60 or &amp;gt;140 mg/dl for only 0.2% and 0.4% of the day, respectively. Sensor glucose concentrations were slightly higher in children than adults (P = 0.009) and were slightly lower during the night than day (95 vs. 99 mg/dl, P &amp;lt; 0.001). CONCLUSIONS Glucose values ≤60 and &amp;gt;140 mg/dl, measured with CGM, are uncommon in healthy, nondiabetic individuals. CGM may be useful to evaluate glucose tolerance in nondiabetic individuals over time. Furthermore, these data provide a basis for comparison for studies that use CGM to assess glucose control in subjects with diabetes.
BLOOD CHOLESTEROL AND CREATINE EXCRETION IN THE URINE AS AIDS TO DIAGNOSIS AND TREATMENT OF HYPOTHYROIDISM
Authors: Julius H. Hess
Journal: Annals of Internal Medicine (1934)

Article1 November 1934BLOOD CHOLESTEROL AND CREATINE EXCRETION IN THE URINE AS AIDS TO DIAGNOSIS AND TREATMENT OF HYPOTHYROIDISMJULIUS H. HESS, F.A.C.P.JULIUS H. HESS, F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-8-5-607 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe clinical symptoms of diminished thyroid activity in their classical form, during infancy and childhood, are too well known to bear repetition. One of the most important problems in the care and treatment of congenital or acquired hypothyroidism during childhood is early recognition. It is reasonable to assume that the longer treatment is delayed, the less opportunity there is of attaining the most desirable therapeutic result. Until recent years, physical signs, clinical symptoms, and basal metabolism determinations were the most important methods of establishing the diagnosis of hypothyroidism.In infants and children, the characteristic physical appearance, subnormal temperature, retardation of...References1. HARRISBRAND MME: Metabolic and therapeutic studies in myopathies, with special reference to glycine administration, Jr. Am. Med. Assoc., 1933, ci, 1047-1052. CrossrefGoogle Scholar2. BRONSTEIN IP: Studies in cretinism and hypothyroidism in childhood; blood cholesterol, Jr. Am. Med. Assoc., 1933, c, 1661-1663. CrossrefGoogle Scholar3. PONCHERVISSCHERWOODWARD HGMBH: Creatine metabolism in children with hypothyroidism, Jr. Am. Med. Assoc., 1934, cii, 1132. CrossrefGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Chicago, Illinois*Read at the Chicago meeting of the American College of Physicians, April 19, 1934. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byFunction of the Hypophysis-Thyroid System in the Rabbit Fœtus with Regard to Cholesterol MetabolismREFERENCESKrankheiten der SchilddrüseThe clinical significance of cholesterolThe Use of the Creatine-Creatinine RatioTierexperimentelle Untersuchungen über den Einfluß der männlichen Keimdrüse auf den CholesterinstoffwechselDisorders of internal gland secretion in children 1 November 1934Volume 8, Issue 5Page: 607-611KeywordsChildrenCholesterolCreatineExcretionHypothyroidismInfantsSigns and symptomsTemperatureThyroidUrine ePublished: 1 December 2008 Issue Published: 1 November 1934 PDF downloadLoading ...