tbuckley/cabot-search huggingface dataset:
Isoimmune Anti-IgA Causing Anaphylactoid Transfusion Reactions
Authors: G. N. Vyas, H. H. Fudenberg
Journal: New England Journal of Medicine (1969)

Nonhemolytic adverse reactions to transfusion of blood and plasma have been grouped together by Mollison1 as "other unfavorable effects of transfusion." Identification of antibodies to leukocytes and platelets in some of these reactions was a consequence of development of suitable serologic methods. Application of chromic chloride as an agent for coupling purified plasma proteins to inert indicator red cells marked the beginning of yet another phase in serologic advances that enable us to detect antibodies to various plasma proteins by a very sensitive and specific passive hemagglutination method.2 This method has been rapidly exploited and applied to various protein-antiprotein systems . . .
Identification of a gene element essential for leukemia-specific expression of transgenes
Authors: N Hosen, M Yanagihara, T Nakazawa, K Kanato, S Nishida, T Shirakata, M Asada, T Masuda, Y Taniguchi, M Kawakami, A Tsuboi, K Ikegame, Y Oka, H Ogawa, I Kawase, Y Oji, H Sugiyama
Journal: Leukemia (2004)
Inflammatory manifestations in a single-center cohort of patients with chronic granulomatous disease
Authors: Alessandra Magnani, Pauline Brosselin, Julien Beauté, Nathalie de Vergnes, Richard Mouy, Marianne Debré, Felipe Suarez, Olivier Hermine, Olivier Lortholary, Stéphane Blanche, Alain Fischer, Nizar Mahlaoui
Journal: Journal of Allergy and Clinical Immunology (2014)
MicroRNA Profiling Can Classify Acute Leukemias of Ambiguous Lineage as Either Acute Myeloid Leukemia or Acute Lymphoid Leukemia
Authors: David C. de Leeuw, Willemijn van den Ancker, Fedor Denkers, Renée X. de Menezes, Theresia M. Westers, Gert J. Ossenkoppele, Arjan A. van de Loosdrecht, Linda Smit
Journal: Clinical Cancer Research (2013)

Classification of acute leukemia is based on the commitment of leukemic cells to the myeloid or the lymphoid lineage. However, a small percentage of acute leukemia cases lack straightforward immunophenotypical lineage commitment. These leukemias of ambiguous lineage represent a heterogeneous category of acute leukemia that cannot be classified as either acute myeloid leukemia (AML) or acute lymphoid leukemia (ALL). The lack of clear classification of acute leukemias of ambiguous lineage as either AML or ALL is a hurdle in treatment choice for these patients.Here, we compared the microRNA (miRNA) expression profiles of 17 cases with acute leukemia of ambiguous lineage and 16 cases of AML, B-cell acute lymphoid leukemia (B-ALL), and T-cell acute lymphoid leukemia (T-ALL).We show that leukemias of ambiguous lineage do not segregate as a separate entity but exhibit miRNA expression profiles similar to AML, B-ALL, or T-ALL. We show that by using only 5 of the most lineage-discriminative miRNAs, we are able to define acute leukemia of ambiguous lineage as either AML or ALL.Our results indicate the presence of a myeloid or lymphoid lineage-specific genotype, as reflected by miRNA expression, in these acute leukemias despite their ambiguous immunophenotype. miRNA-based classification of acute leukemia of ambiguous lineage might be of additional value in therapeutic decision making.
Lack of expertise and funding are hampering prostate cancer screening and treatment
Authors: C. White
Journal: BMJ (2002)

A lack of widespread expertise and adequate funding–rather than the screening test itself–is hampering screening for and treatment of prostate cancer, claims a leading cancer epidemiologist.

Professor Peter Boyle, of the European Institute of Oncology, was speaking in advance of a conference on the opportunities and challenges faced by screening programmes in London last week. One in 14 men will develop prostate cancer, the second most common cancer in men in the United Kingdom, and 9500 men die from the disease every year. Four out of five cases diagnosed are in men over the age of …
(39) Morphoea with skeletal foot deformity
Authors: H.K. Shamy
Journal: British Journal of Dermatology (1987)

Journal Article (39) Morphoea with skeletal foot deformity Get access H.K. Shamy H.K. Shamy York District Hospital Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 117, Issue s32, 1 June 1987, Pages 91–92, https://doi.org/10.1111/j.1365-2133.1987.tb12079.x Published: 01 June 1987
PRE-PROCEDURAL HIGH-SENSITIVITY C-REACTIVE PROTEIN PREDICTS DEATH, RECURRENT MYOCARDIAL INFARCTION AND STENT THROMBOSIS ACCORDING TO STENT TYPE IN PATIENTS WITH ST-SEGMENT ELEVATION MYOCARDIAL INFARCTION TREATED WITH PRIMARY PERCUTANEOUS CORONARY INTERVENTION
Authors: Mikkel M. Schoos, Henning Kelbæk, Klaus F. Kofoed, Lars Køber, Lene Kløvgaard, Steffen Helqvist, Thomas Engstrøm, Kari Saunamäki, Erik Jørgensen, Lene Holmvang, Peter Clemmensen
Journal: Journal of the American College of Cardiology (2011)
Association between Genetic Variations in FGF receptors and Airway Hyperresponsiveness
Authors: S. Sohn, H. Kwon, K. Kim, C. Park, H. Kim, S. Kim, H. Park, H. Park, Y. Jeong, S. Kim, Y. Jang, Y. Kim, S. Cho, K. Min, Y. Kim
Journal: Journal of Allergy and Clinical Immunology (2006)
From Research to Health Care Practice
Authors: Bridget M. Kuehn
Journal: JAMA (2010)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Neural reuse and cognitive homology
Authors: Vincent Bergeron
Journal: Behavioral and Brain Sciences (2010)

Abstract Neural reuse theories suggest that, in the course of evolution, a brain structure may acquire or lose a number of cognitive uses while maintaining its cognitive workings (or low-level operations) fixed. This, in turn, suggests that homologous structures may have very different cognitive uses, while sharing the same workings. And this, essentially, is homology thinking applied to brain function.
Nitric Oxide Attenuates Neutrophil-Mediated Myocardial Contractile Dysfunction After Ischemia and Reperfusion
Authors: Ravinder Pabla, Andrew J. Buda, David M. Flynn, Steven A. Blessé, Alice M. Shin, Michael J. Curtis, David J. Lefer
Journal: Circulation Research (1996)

Abstract With the knowledge of NO as an antiadhesion molecule, we performed studies to investigate the effects of NO on postischemic polymorphonuclear leukocyte (PMN)–mediated myocardial contractile dysfunction. Studies were performed with isolated perfused rat hearts subjected to 20 minutes of global ischemia and 45 minutes of reperfusion. Human PMNs (50 million) were infused over the first 5 minutes of reperfusion, and the recovery of left ventricular function was compared with baseline values. Infusion of PMNs alone (n=10) led to a 61% reduction in left ventricular developed pressure (LVDP) and a 57% reduction in the pressure-rate product (PRP) at 45 minutes of reperfusion. Infusion of an NO donor, CAS-754 (n=9), resulted in 80.2±6.7% recovery of LVDP and 77.0±8.6% recovery of PRP. Treatment with l -arginine (2.5 mmol/L, n=10) resulted in a similar improvement in the postischemic contractile state of the heart. In contrast, N G -nitro- l -arginine methyl ester (L-NAME) treatment (250 μmol/L, n=10) resulted in an exacerbation of contractile dysfunction, as evidenced by a 93% reduction in LVDP at 45 minutes of reperfusion and a 91% reduction in PRP. The deleterious effects of L-NAME were prevented by l -arginine coperfusion. We failed to observe any cardioprotective effects when NO or l -arginine was administered to hearts subjected to 25 minutes of ischemia and 45 minutes of reperfusion in the absence of PMNs. In conclusion, PMN-mediated myocardial contractile dysfunction is attenuated by NO and exacerbated by blockade of NO synthesis.
Encouraging Physical Activity
Authors: Ross E. Andersen
Journal: Annals of Internal Medicine (1998)

Letters1 April 1998Encouraging Physical ActivityRoss E. Andersen, PhD and Steve N. Blair, PEDRoss E. Andersen, PhDJohns Hopkins School of Medicine; Baltimore, MD 21224Cooper Institute for Aerobics Research; Dallas, TX 75230Search for more papers by this author and Steve N. Blair, PEDJohns Hopkins School of Medicine; Baltimore, MD 21224Cooper Institute for Aerobics Research; Dallas, TX 75230Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-128-7-199804010-00035 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail IN RESPONSE:We appreciate Dr. McDuffie's and Dr. Malkin's interest in our recent paper. Both have reiterated the importance of being a good role model for patients. We commend Dr. McDuffie on his own commitment to regular vigorous physical activity. He addresses the key point of tailoring and individualizing exercise prescriptions to meet the individual health needs of each patient. Our paper focused on how to help apparently healthy adults adopt a more active lifestyle. However, as Dr. McDuffie notes, patients with musculoskeletal limitations or other medical ailments can also get symptom relief through regular activity.Dr. Malkin suggests that ...References1. Andersen RE, Brownell KD, Haskell WL. The Health and Fitness Club Leader's Guide: Administering a Weight Management Program. Dallas: American Health Publishing; 1992. Google Scholar2. Long BJ, Calfas KJ, Wooten W, Sallis JF, Patrick K, Goldstein M, et al. A multisite field test of the acceptability of physical activity counseling in primary care: project PACE. Am J Prevent Med. 1996; 12:73-81. Google Scholar3. Physical Activity and Health: A Report of the Surgeon General. Atlanta: U.S. Department of Health and Human Services, Centers for Disease Control and Prevention, National Center for Chronic Disease Prevention and Health Promotion; 1996. Google Scholar Author, Article, and Disclosure InformationAuthors: Ross E. Andersen, PhD; Steve N. Blair, PEDAffiliations: Johns Hopkins School of Medicine; Baltimore, MD 21224Cooper Institute for Aerobics Research; Dallas, TX 75230 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 April 1998Volume 128, Issue 7Page: 606KeywordsExerciseHypertensionSports ePublished: 15 August 2000 Issue Published: 1 April 1998 Copyright & PermissionsCopyright © 1998 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Drugs in Pregnancy and Lactation
Authors: Jeanne Manson
Journal: Annals of Internal Medicine (1999)

Medical Writings: Book Notes16 February 1999Drugs in Pregnancy and LactationJeanne Manson, PhD and Michelle Berlin, MD, MPHJeanne Manson, PhDCenter for Clinical Epidemiology and Biostatistics, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania (Manson)Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania. (Berlin)Search for more papers by this author and Michelle Berlin, MD, MPHCenter for Clinical Epidemiology and Biostatistics, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania (Manson)Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania. (Berlin)Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-130-4_Part_1-199902160-00024 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail 5th edition. Briggs GG, Freeman RK, Yaffee SJ; eds. 1220 pages. Baltimore: Williams & Wilkins; 1998. $105.00. ISBN 0683302620. Order phone 800-638-0672.Field of medicine: Obstetrics, pediatrics, family practice, genetic counseling, and pharmacy.Format: Hardcover book.Audience: Health care providers who see women planning pregnancies, pregnant and nursing women, and parents of infants with developmental disabilities.Purpose: To aid in the management of pregnant and nursing women who have inadvertently been exposed to a drug or who require drug therapy for serious conditions.Content: More than 800 monographs cover approximately 100 new drugs and update information on older ones. Drugs ...References1. FDA classification of drugs for teratogenic risk. Teratology Society Public Affairs Committee. Teratology. 1994; 49:446-7, 1994. Google Scholar2. Friedman JM, Little BB, Brent RL, Cordero JF, Hanson JW, Shepard TH. Potential human teratogenicity of frequently prescribed drugs. Obstet Gynecol. 1990;75:594-9. MedlineGoogle Scholar Author, Article, and Disclosure InformationAffiliations: Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania (Manson)Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania. (Berlin) PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 16 February 1999Volume 130, Issue 4_Part_1Page: 332KeywordsComputersDatabasesDrug informationDrug therapyDrugsFood and Drug AdministrationLactationPediatricsPregnancyRisk management Issue Published: 16 February 1999 Copyright & PermissionsCopyright © 1999 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
MONOCYTE CHEMOATTRACTANT PROTEIN 1 PREDICTS FIRST CORONARY EVENTS BUT NOT RECURRENT STROKES: RESULTS FROM THE SPARCL STUDY
Authors: Peter Ganz, Pierre Amarenco, Larry Goldstein, Henrik Sillesen, Weihang Bao, Gregory M. Preston, K. Michael Welch
Journal: Journal of the American College of Cardiology (2010)
Irish junior doctors spend too little time being trained
Authors: D. Payne
Journal: BMJ (2001)

Irish junior doctors are spending an average of only 4% of their working day studying or receiving formal training. A report released last week by the national joint steering group on the working hours of non-consultant hospital doctors said that consultants have too little time to provide training and non-consultants are often “too busy to attend that which is provided.”

As a result, the report added, many of the non-consultant hospital doctors “feel that they are …
Physicians and Patients Need an Electronic Card
Authors: Ahmed F. Ghouri
Journal: JAMA (1992)

<h3>To the Editor.</h3> —As a physician and founder of a software development company, I was appalled to read in the recent issue of<i>JAMA</i><sup>1</sup>that a proposal by Louis Sullivan, secretary of the Department of Health and Human Services, for medical recordkeeping on a personal credit card has drawn such criticism. It has been suggested that this card "is to protect the special interests of those who are profiteering from the health care system, as opposed to... the consumers," and that it represents a "gimmick" whose principal purpose is to improve cash flow, not access. I have always assumed it to be evident that deciphering cryptic handwriting and requesting old medical records over and over again is a waste of a physician's time, as well as a health risk to the patient when errors occur in obtaining this vital information. I encourage critics of Dr Sullivan's proposal to
Oncogenic activation of the Notch1 gene by deletion of its promoter in Ikaros-deficient T-ALL
Authors: Robin Jeannet, Jérôme Mastio, Alejandra Macias-Garcia, Attila Oravecz, Todd Ashworth, Anne-Solen Geimer Le Lay, Bernard Jost, Stéphanie Le Gras, Jacques Ghysdael, Thomas Gridley, Tasuku Honjo, Freddy Radtke, Jon C. Aster, Susan Chan, Philippe Kastner
Journal: Blood (2010)
INSTRUMENT FOR IMPROVED IRRIGATION OF LUNG ABSCESSES, WITH ESPECIAL REFERENCE TO UPPER LOBE ABSCESS
Authors: M. C. Myerson
Journal: JAMA (1924)

Until Clerf brought out his modification of Lynah's spring tube for the irrigation of upper lobe suppurations, these lesions were practically ignored by the bronchoscopist. The tube that I am presenting was perfected at the time that the Clerf tube was announced. It has proved very satisfactory. I have adapted the Lynah tube to the Yankauer suction irrigation tube, and as a result have a tube that can be inserted not only into the upper lobe bronchus, but also into any branch bronchus from which pus may be found exuding. In other words, this tube can be used for all point of entry of the washings into the larger bronchial element. This is not attainable with the suction bronchoscope and a single irrigating tube. Therefore, we can feel that our irrigation is more thorough. The spiral end, which is straight while inside the bronchoscope, becomes curved on its emergence from
Medical Management of Aldosterone-Producing Adenomas
Authors: Nor N. Chan
Journal: Annals of Internal Medicine (2000)

Letters4 April 2000Medical Management of Aldosterone-Producing AdenomasNor N. Chan, MB, ChB, MRCPNor N. Chan, MB, ChB, MRCPUniversity College London; London, United Kingdom (Chan)Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-132-7-200004040-00022 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:Ghose and colleagues (1) showed that long-term medical management (5 to 17 years) is a reasonable option for aldosterone-producing adenomas diagnosed by standard biochemistry and computed tomography in terms of blood pressure control and normalization of serum potassium levels in patients who decline or are unfit for surgery. However, I have concerns about the diagnostic accuracy in their cohort of patients. The use of computed tomography alone without adrenal venous sampling is often inadequate in differentiating between aldosterone-producing adenomas and adrenocortical hyperplasia (2, 3), the two major causes of primary hyperaldosteronism. In a series of hypertensive patients ...References1. Ghose RP, Hall PM, Bravo EL. Medical management of aldosterone-producing adenomas. Ann Intern Med. 1999;131:105-8. LinkGoogle Scholar2. Doppman JL, Gill JR, Miller DL, Chang R, Gupta R, Friedman TC, et al . Distinction between hyperaldosteronism due to bilateral hyperplasia and unilateral aldosteronoma: reliability of CT. Radiology. 1992;184:677-82. CrossrefMedlineGoogle Scholar3. Linde R, Coulam C, Battino R, Rhamy R, Gerlock J, Hollifield J. Localization of aldosterone-producing adenoma by computed tomography. J Clin Endocrinol Metab. 1979;49:642-5. CrossrefMedlineGoogle Scholar4. McAlister FA, Lewanczuk RZ. Primary hyperaldosteronism and adrenal incidentaloma: an argument for physiological testing before adrenalectomy. Can J Surg. 1998;41:299-305. MedlineGoogle Scholar5. Saruta T, Suzuki H, Takita T, Saito I, Murai M, Tazaki H. Pre-operative evaluation of the prognosis of hypertension in primary aldosteronism owing to adenoma. Acta Endocrinol. 1987;116:229-34. CrossrefMedlineGoogle Scholar Author, Article, and Disclosure InformationAffiliations: University College London; London, United Kingdom (Chan) PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoMedical Management of Aldosterone-Producing Adenomas Ranjan P. Ghose , Phillip M. Hall , and Emmanuel L. Bravo Medical Management of Aldosterone-Producing Adenomas J.B. Ferriss Metrics 4 April 2000Volume 132, Issue 7Page: 594KeywordsAdenomasAdrenalectomyBiochemistryBlood pressureComputed axial tomographyHypertensionPositive predictive valuePotassiumSpecificitySurgery ePublished: 15 August 2000 Issue Published: 4 April 2000 Copyright & PermissionsCopyright © 2000 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Rondel: Déjà Vu
Authors: Valerie Wohlfeld
Journal: JAMA (2009)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Streptavidin Paramagnetic Particles Provide a Choice of Three Affinity-Based Capture and Magnetic Concentration Strategies for Retroviral Vectors
Authors: C. Hughes, J. Galea-Lauri, F. Farzaneh, D. Darling
Journal: Molecular Therapy (2001)

Three strategies have been designed to concentrate infectious retroviral vectors from the supernatants of human- (HT1080) and murine- (NIH 3T3) based packaging cells. Streptavidin-conjugated paramagnetic particles in conjunction with (i) antibodies directed against murine fibronectin, (ii) biotinylated lectins, or (iii) biotin-modified packaging cell-surface proteins allow affinity-mediated magnetic concentration of retroviral vectors. Retroviral titers (assayed by colony formation of human myeloid K562 cells) are increased by 1-4 x 10(3)-fold after volume reductions of only 125-fold. Using these procedures, preparations of 5 x 10(8) cfu/ml are routinely made from relatively low-titer (2-5 x 10(5) cfu/ml) starting material. High-titer (paramagnetic) retroviral vector preparations can be used for magnetic field-dependent retroviral infection in vitro. Magnetic field-dependent localization such as this may enable the in vivo administration of formulations that concentrate retroviral infection to the required target tissues and organs.
Ammonia and partial pressure of ammonia — correlation with postural control, Child-Pugh-stage and reitan a test in patients with cirrhosis
Authors: Monika Schmid, Christian Mittermayer, Georg-Christian Funk, Bernhard Voller, Veronika Fialka-Moser, Alfred Gangl, Markus Peck-Radosavljevic
Journal: Journal of Hepatology (2002)