tbuckley/cabot-search huggingface dataset:
Transient ascites in progressive systemic sclerosis.
Authors: J J McAleer, S R Cunningham, W Dickey, D Burrows, M E Callender
Journal: BMJ (1986)

appeared earliest, as previously reported,4 5 and before day 11 of illness, coincident with the appearance of activated lymphocytes.Antienvelope protein antibodies, p41, and gpl20/160 (data not shown; Gerald Robey) were first detected faintly at day 16, coincident with clinical improvement.Days after onset of illness o .Positive 1983 4 11 12 16 27 42 52 57 control p64 p55 p53 C .p41 0 ~~~p31-0 -p24-Appearance of antibody to HIV, as shown by Western blot analysis, in patient with acute febrile encephalopathy (days 2-15) and residual lymphopahy.Western blot analysis was performed with HIV grown in H9 cell lines.Serum obtained during the illness was analysed in the same tray using an avidin-biotinperoxidase technique to show antibody attachment to HIV polypeptides.4Serum from 1983 was available from a previous study.Antibodies against other antigens (p15, p31, p53, p64) appeared before day 27, coincident with the development of persistent generalised lymphadenopathy.Thus severe symptoms including an illness similar to mononucleosis, encephalopathy, and persistent generalised lymphadenopathymay occur as a consequence of primary HIV infection.Whether this profile development ofantibody to HIV is typical of other seroconversions remains unknown.I Anonymous.
Case 10-1983
Authors: Richard C. Cabot, Robert E. Scully, Eugene J. Mark, Betty U. McNeely, William E. Strole, Randall J. Margolis
Journal: New England Journal of Medicine (1983)

Presentation of CaseA 25-year-old woman was admitted to the hospital because of syncope.She was well until five days earlier, when she began to experience orthostatic dizziness, nausea, and sweating, accompanied by the passage of tarry stools. Crampy pain in both lower abdominal quadrants prompted the removal of an intrauterine device, which had been inserted one month earlier; there was no improvement in the symptoms. On the day of admission she lost consciousness while walking to work and was brought to the Emergency Ward.Grand-mal seizures developed when the patient was 11 years of age and were controlled with . . .
Natural Interferon α/β–Producing Cells Link Innate and Adaptive Immunity
Authors: Norimitsu Kadowaki, Svetlana Antonenko, Johnson Yiu-Nam Lau, Yong-Jun Liu
Journal: The Journal of Experimental Medicine (2000)

Innate immune responses to pathogens critically impact the development of adaptive immune responses. However, it is not completely understood how innate immunity controls the initiation of adaptive immunities or how it determines which type of adaptive immunity will be induced to eliminate a given pathogen. Here we show that viral stimulation not only triggers natural interferon (IFN)-α/β–producing cells (IPCs) to produce vast amounts of antiviral IFN-α/β but also induces these cells to differentiate into dendritic cells (DCs). IFN-α/β and tumor necrosis factor α produced by virus-activated IPCs act as autocrine survival and DC differentiation factors, respectively. The virus-induced DCs stimulate naive CD4+ T cells to produce IFN-γ and interleukin (IL)-10, in contrast to IL-3–induced DCs, which stimulate naive CD4+ T cells to produce T helper type 2 cytokines IL-4, IL-5, and IL-10. Thus, IPCs may play two master roles in antiviral immune responses: directly inhibiting viral replication by producing large amounts of IFN-α/β, and subsequently triggering adaptive T cell–mediated immunity by differentiating into DCs. IPCs constitute a critical link between innate and adaptive immunity.
Taxation alone cannot save the NHS, says report
Authors: C. Court
Journal: BMJ (1995)

The gap between resources and demand within the NHS will widen unless radical action is taken to find additional funding, says a new report on Britain's health care. The report, from Healthcare 2000, backs the principle of general taxation as the primary source of funding for the NHS but says that increased taxation alone cannot close the gap.

The report observes that all developed countries have a mix of public and private finance for health services and adds: “Relative to other …
No green light for grass in glaucoma
Authors: Elizabeth Rasche González
Journal: JAMA (1980)

What's new in the area of marijuana treatment for glaucoma? Not much, said Keith Green, PhD, Regents Professor of Ophthalmology, Medical College of Georgia, Augusta, in an interview with<i>JAMA</i>MEDICAL NEWS. Green is engaged in an ongoing effort to screen the naturally occurring and synthetic cannabinoids, as well as the water-soluble molecular components of the marijuana plant, for their intraocular pressure-lowering effects by testing them in rabbits. (There is no good animal model for glaucoma, and even these rabbits have normal intraocular pressure.) But so far, Green says, "It looks as if we can't have the pressure fall without the euphoriant effect." Essentially, then, a patient who wishes to use a cannabinoid to control his intraocular pressure satisfactorily must stay "stoned" all day. Other undesirable side effects of the cannabinoids include tachycardia, conjunctival hyperemia, respiratory and reproductive changes, and visual problems (for example, difficulties with color vision and dark
Favus due to<i>Trichophyton schoenleinii</i>in a patient with metastatic bronchial carcinoma
Authors: R. Cecchi, S. Paoli, A. Giomi, R. Rossetti
Journal: British Journal of Dermatology (2003)

Journal Article Favus due to Trichophyton schoenleinii in a patient with metastatic bronchial carcinoma Get access R. Cecchi, R. Cecchi Departments of Dermatology and R.Cecchi. E‐mail: a.giomi@mail.pt.usl3.toscana.it Search for other works by this author on: Oxford Academic Google Scholar S. Paoli, S. Paoli Departments of Dermatology and Search for other works by this author on: Oxford Academic Google Scholar A. Giomi, A. Giomi Departments of Dermatology and Search for other works by this author on: Oxford Academic Google Scholar R. Rossetti R. Rossetti Microbiology, Spedali Riuniti, 51100 Pistoia, Italy Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 148, Issue 5, 1 May 2003, Page 1057, https://doi.org/10.1046/j.1365-2133.2003.05310.x Published: 01 May 2003 Article history Accepted: 22 November 2002 Published: 01 May 2003
Aluminium potroom asthma confirmed by monitoring of forced expiratory volume in one second.
Authors: A Desjardins, J P Bergeron, H Ghezzo, A Cartier, J L Malo
Journal: American Journal of Respiratory and Critical Care Medicine (1994)

Chronic airflow obstruction has long been seen among aluminium potroom workers. Currently referred to as "potroom asthma," it is debatable as to whether it is occupational asthma or nonspecific airway obstruction. A 35-yr-old male lifelong nonsmoker, with no history of asthma or atopy, was hired by an aluminium plant that had begun its operation in 1986. Preemployment screening, consisting of spirometry and a chest radiograph, was normal. During his 12-h shifts, he replaced 10 to 20 anodes (prebake type), spending 5 min each time close to open pots releasing hot fumes. The patient experienced episodes of cough and dyspnea, which were resolved during withdrawal from work in January and December 1991. He resumed work in the potrooms in March 1992, his dyspnea recurred at work and at night with 25% drops in peak expiratory flow rates (PEFR), associated with mild-to-moderate bronchial hyperresponsiveness (PC20 histamine, 1.0 mg/ml). After a chest physician's assessment, he was withdrawn from the potroom department. Assessment of the bronchial response to the occupational exposure in potrooms carried out in November 1992 revealed a pattern of dual asthmatic response, paralleled by a drop in PC20 methacholine from 5.1 to 0.7 mg/ml. A similar pattern was seen again during repeat workplace challenges 3 wk later. Spirometry obtained on control days was stable. We conclude that asthmatic reactions can exist among workers in aluminium smelters.
Anorexia nervosa in diabetes mellitus.
Authors: J Gomez, P Dally, A J Isaacs
Journal: BMJ (1980)

<h3>Objectives</h3> Rates of vulvar cancer are increasing globally. Early detection reduces surgical morbidity and prolongs survival. Although population screening has no role, vulvar self-examination may prompt early diagnosis in high-risk women. UK guidance promotes self-examination in women with high-risk vulvar conditions, but there is a lack of evidence about current practice, acceptability and barriers to vulvar self-examination. <h3>Methods</h3> Clinician questionnaires were completed at a UK vulvar conference. Patient questionnaires (incorporating vulvar self-examination and cancer awareness) were distributed through patient networks and clinics. <h3>Results</h3> All ninety-eight clinicians agreed that self-examination plays an important role in detecting sinister vulvar changes in high-risk women. 87% recommended monthly self-examination and 81% provided one-to-one teaching despite believing that few patients practised self-examination. 455 patients (median age 58 years) with lichen sclerosus(69%), lichen planus(13%), vulvar cancer(14%) and VIN(13%) participated. Clinic respondents(n=197) were older(median 65 vs 52 years, p&lt;0.001) and 65% reported self-examining compared with 86% of online respondents(p&lt;0.001). Despite regular self-examination, 40% were not confident about recognising vulvar abnormalities. Lack of awareness(38%), confidence(31%) and physical difficulties visualising the vulva(32%) were top barriers to self-examination. Face-to-face specialist teaching was regarded as the best way to learn self-examination but only 9% of patients reported receiving this. Patients agreed that a magnified, extendable mirror and photographs depicting sinister changes would aid self-examination. <h3>Conclusions</h3> Patients and clinicians recognise that vulvar self-examination is important in early detection of cancer, but a lack of formal teaching impairs confidence in the identification of abnormalities. Visual aids may facilitate self-examination but should be reinforced by education and support.
A Mendelian Presentation of Multiple TH2-Mediated Allergic Diseases
Authors: Pamela A. Frischmeyer-Guerrerio, Anthony Guerrerio, Gretchen Oswald, Kristin Chichester, Loretha Meyers, Marc Halushka, Maria Oliva-Hemker, Robert A. Wood, Harry Dietz
Journal: Journal of Allergy and Clinical Immunology (2013)
Acarbose ameliorates atherogenecity of low-density lipoprotein in patients with impaired glucose tolerance
Authors: Ikuo Inoue, Yuichi Shinoda, Takanari Nakano, Masatoshi Sassa, Sei-ichi Goto, Takuya Awata, Tsugikazu Komoda, Shigehiro Katayama
Journal: Metabolism (2006)
Biomedical Research: Collaboration and Conflict of Interest
Authors: Herman S. Wigodsky
Journal: JAMA (1993)

In the words of the authors, "This volume provides an analysis of the impact of industry and academia on biomedical research and how these institutions work together. The analysis begins with the moral imperative for biomedical research and ends with an analysis of how the US federal government regulates its own laboratories." In the middle of the book, one of the authors, Roger J. Porter, points out that the main impact of conflict of interest in research is to produce biased results or biased interpretation of results, and this is the focus of one chapter. The volume grew from the extraordinary opportunity for Porter to be a scholar-in-residence in the Division of Biomedical Research of the Association of American Medical Colleges, a division under the direction of the other editor, Thomas E. Malone. Porter is deputy director of the National Institute of Neurological Disorders and Stroke, National Institutes of Health
Screening in Planarians Identifies MORN2 as a Key Component in LC3-Associated Phagocytosis and Resistance to Bacterial Infection
Authors: Prasad Abnave, Giovanna Mottola, Gregory Gimenez, Nicolas Boucherit, Virginie Trouplin, Cedric Torre, Filippo Conti, Amira Ben Amara, Catherine Lepolard, Benjamin Djian, Daniel Hamaoui, Amel Mettouchi, Atul Kumar, Sophie Pagnotta, Stefano Bonatti, Hubert Lepidi, Alessandra Salvetti, Laurent Abi-Rached, Emmanuel Lemichez, Jean-Louis Mege, Eric Ghigo
Journal: Cell Host & Microbe (2014)
Gastroesophageal Variceal Hemorrhage
Authors: Ala I. Sharara, Don C. Rockey
Journal: New England Journal of Medicine (2001)

Gastroesophageal variceal hemorrhage, a major complication of portal hypertension resulting from cirrhosis, accounts for 10 to 30 percent of all cases of bleeding from the upper gastrointestinal tract.1 Variceal hemorrhage occurs in 25 to 35 percent of patients with cirrhosis and accounts for 80 to 90 percent of bleeding episodes in these patients.24 Variceal hemorrhage is associated with more substantial morbidity and mortality than other causes of gastrointestinal bleeding, as well as with higher hospital costs.57 Up to 30 percent of initial bleeding episodes are fatal, and as many as 70 percent of survivors have recurrent bleeding after . . .
Quantitative detection of regional left ventricular contraction abnormalities by two-dimensional echocardiography. II. Accuracy in coronary artery disease.
Authors: A F Parisi, P F Moynihan, E D Folland, C L Feldman
Journal: Circulation (1981)

The quantitative approaches to the assessment of regional left ventricular (LV) function described in the preceding paper were applied in a well-defined population of patients with coronary artery disease. Two groups were chosen by electrocardiographic and angiographic criteria: group 1 had infarction and regional wall motion abnormalities and group 2 had no infarction and normal wall motion. Sensitivity to detect wall motion defects, specificity to correctly categorize normal segments, and overall predictive accuracy were evaluated for each two-dimensional echocardiographic approach. In addition, the ability of each method to localize regional contraction defects properly was evaluated. Area methods yielded better predictive accuracy than linear methods (87-95% vs 76-84%). No significant differences in accuracy were noted between quadrant and octant approaches. The fixed external-axis system was superior to a floating one for localizing contraction defects. We conclude that an area-based method, using a fixed-axis system and either octant or quadrant image subdivision, provides the best combination of predictive accuracy in categorizing LV segments as normal or abnormal and the greatest ability to localize LV regional abnormalities.
Selective Screening for Gestational Diabetes Mellitus
Authors: C. David Naylor, Mathew Sermer, Erluo Chen, Dan Farine
Journal: New England Journal of Medicine (1997)

The usual approach to detecting gestational diabetes mellitus is to screen all pregnant women by measuring their plasma glucose after a 50-g oral glucose load at 24 to 28 weeks' gestation. Women are referred for an oral glucose-tolerance test if the plasma glucose concentration one hour later is >140 mg per deciliter (7.8 mmol per liter). We hypothesized that the efficiency of screening could be enhanced by considering women's risks of gestational diabetes on the basis of their clinical characteristics.
Large Atrial Myxoma
Authors: Aman Mundi
Journal: New England Journal of Medicine (2009)

A 57-year-old woman presented with a 4-month history of leg swelling and dyspnea on exertion. Physical examination revealed a grade 3/6 holosystolic murmur at the right upper sternal border and an early diastolic decrescendo murmur at the left lower sternal border.
Improved Effects of Viral Gene Delivery of Human uPA plus Biliodigestive Anastomosis Induce Recovery from Experimental Biliary Cirrhosis
Authors: Alejandra Miranda-Díaz, Ana Rosa Rincón, Silvia Salgado, José Vera-Cruz, Javier Gálvez, Ma Cristina Islas, Jaime Berumen, Estuardo Aguilar Cordova, Juan Armendáriz-Borunda
Journal: Molecular Therapy (2003)

Gene therapy may represent a new avenue for the development of multimodal treatment for diverse forms of cirrhosis. This study explores the potential benefits of combining adenovirus-mediated human urokinase-plasminogen activator (AdHuPA) gene delivery and biliodigestive anastomosis to enhance the therapeutic efficacy of each treatment alone for cholestatic disorders resulting in secondary biliary cirrhosis. In an experimental model of secondary biliary cirrhosis, application of 6 x 10(11) vp/kg AdHuPA adenovirus vector resulted in 25.8% liver fibrosis reduction and some improvement in liver histology. The relief of bile cholestasis by a surgical procedure (biliodigestive anastomosis) combined with AdHuPA hepatic gene delivery rendered a synergistic effect, with a substantial 56.9 to 42.9% fibrosis decrease. AdHuPA transduction resulted in clear-cut expression of human uPA protein detected by immunohistochemistry and induction of up-regulation in the expression of metalloproteinases MMP-3, MMP-9, and MMP-2. Importantly, functional hepatic tests, specifically direct bilirubin, were improved. Also, hepatic cell regeneration, rearrangement of hepatic architecture, ascites, and gastric varices improved in cirrhotic rats treated with AdHuPA but not in counterpart AdGFP cirrhotic animals. We believe this might represent a novel therapeutic strategy for human cholestatic diseases.
Characterization of antigens from nontypable Haemophilus influenzae recognized by human bactericidal antibodies. Role of Haemophilus outer membrane proteins.
Authors: H E Gnehm, S I Pelton, S Gulati, P A Rice
Journal: Journal of Clinical Investigation (1985)

Major outer membrane antigens, proteins, and lipopolysaccharides (LPSs), from nontypable Haemophilus influenzae were characterized and examined as targets for complement-dependent human bactericidal antibodies. Outer membranes from two nontypable H. influenzae isolates that caused otitis media and pneumonia (middle ear and transtracheal aspirates) were prepared by shearing organisms in EDTA. These membranes were compared with membranes prepared independently by spheroplasting and lysozyme treatment of whole cells and found to have: similar sodium dodecyl sulfate-polyacrylamide gel electrophoresis (SDS-PAGE) patterns of the proteins; identical densities (rho = 1.22 g/cm3); and minimal d-lactose dehydrogenase activity indicating purity from cytoplasmic membranes. Outer membranes were solubilized in an LPS-disaggregating buffer and proteins were separated from LPS by molecular sieve chromatography. The SDS-PAGE patterns of outer membrane proteins (OMPs) from the two strains differed in the major band although other prominent bands appeared similar in molecular weight. LPS prepared by hot phenol water extraction of each of the strains contained 45% (pneumonia isolate) and 60% (otitis isolate) lipid (wt/wt), 49% and 50% carbohydrate (wt/wt), respectively, and less than 1%, 3-deoxy-manno octulosonic acid. Immunoglobulin M (IgM) purified from normal human serum (NHS) plus complement was bactericidal for both strains. Purified immunoglobulin G (IgG) from NHS killed the middle ear isolate and immune convalescent IgM from the serum of the patient with pneumonia killed his isolate. NHS or convalescent serum were absorbed with OMPs and LPS (0.6-110 micrograms) from each of the strains and immune specific inhibition of bactericidal antibody activity by each antigen was determined. OMPs from the pulmonary isolate inhibited bactericidal antibody activity directed against the isolate in both NHS (1.5 microgram of antigen) and immune serum (0.75 microgram of antigen). OMPs (60 micrograms) from the ear isolate also inhibited bactericidal activity in the respective immune serum. LPSs exhibited minimal inhibition (greater than 110 micrograms). Three human sera (two normal, one immune) were selectively depleted of 80% of antibody activity against OMPs (measured by enzyme-linked immunosorbent assay) by affinity chromatography using OMPs from the pulmonary isolate coupled to a solid phase. These OMP antibody-depleted sera also showed an 88% reduction of bactericidal activity against this strain. Immunopurified antibody against OMPs eluted from the solid phase was bactericidal.
Estriol in the Management of the Menopause
Authors: Vassilios A. Tzingounis
Journal: JAMA (1978)

Estriol was administered for a six-month period as estrogen replacement therapy to 52 symptomatic postmenopausal women. Assays of serum follicle-stimulating hormone (FSH), luteinizing hormone (LH), estrone, and estradiol were performed before and during therapy. During this period of administration, vaginal cytology, cervical mucus, and endometrial studies were performed. Clinical effectiveness was directly related to dosage (2 to 8 mg/day). Estriol (8 mg/day) failed to induce endometrial proliferation and proved a poor suppressor of FSH and LH. This agent's capacity to relieve vasomotor instability and improve vaginal maturation without notable side effects is sufficient reason to include this drug in the management of the postmenopausal syndrome.
Unusual Extracardiac Findings Detected on Myocardial Perfusion Single Photon Emission Computed Tomography Studies With Tc-99m Sestamibi
Authors: Gonca Kara Gedik, Eser Lay Ergün, Mehmet Aslan, Biray Caner
Journal: Clinical Nuclear Medicine (2007)

The authors describe the incidence and various uptake patterns of Tc-99m sestamibi (MIBI) in the extracardiac area due to unusual causes on myocardial perfusion single photon emission computed tomography (SPECT) studies. Seven patients are presented in whom incidental extracardiac findings were observed during the interpretation of the raw data besides the routine evaluation of myocardial reconstructed SPECT slices. These 7 patients were detected out of 582 consecutive patients (1.2%) who had myocardial perfusion SPECT with Tc-99m MIBI. The findings on the raw data led to additional reconstruction of thoracic SPECT images and eventually detailed examination of the extracardiac area. Two of the patients underwent surgery because of incidental extracardiac findings (thymoma and multinodular goiter) on cardiac scintigraphy. Other causes of increased extracardiac activity were the intestine protruded through the left hemithorax, uptake in the pulmonary arterial wall, and pulmonary interstitial fibrosis due to sarcoidosis. The reasons for decreased Tc-99m MIBI accumulation in the extracardiac area in the 2 other patients were significantly dilated pulmonary arteries and hydatic cyst, which were not defined before to our knowledge. Familiarity with the normal biodistribution and variable uptake patterns in the raw images becomes necessary during the interpretation of myocardial SPECT in order not to miss very unusual incidental extracardiac uptake or information that could lead to alteration in patient management. Potential underlying mechanisms of extracardiac Tc-99m MIBI accumulation are discussed, and the literature about noncardiac Tc-99m MIBI findings detected on myocardial perfusion SPECT studies was reviewed.
Pulmonary embolism in surgical patients: 1959-79.
Authors: C V Ruckley, C Thurston
Journal: BMJ (1982)

The Edinburgh surgical statistics (audit) have been analysed for the years 1959, 1964, 1969, 1974, and 1979 to determine the trends in pulmonary embolism in surgical patients who died. There was a total of 61,038 operations, 1528 postoperative deaths, 804 necropsies, and 158 reported pulmonary emboli. The incidence of embolism diagnosed clinically and at necropsy fell throughout the period. This fall held good after corrections for necropsy rates, prognosis, and proportions of major operations. Although the overall necropsy rate fell from 58% to 40%, in patients expected to have a good prognosis the rate rose from 68% to 75%. Necropsy-proved embolism in "good prognosis" patients fell from 0.5% to 0.15% per 100 major operations. The main reduction has taken place since most surgeons in the area adopted methods of prophylaxis against venous thrombosis, but a direct relationship is not proved by this study.