tbuckley/cabot-search huggingface dataset:
Gastrointestinal investigation of iron deficiency anaemia
Authors: M V Tobin, I T Gilmore
Journal: BMJ (1986)

fact that half of all students will become GPs and very few specialist ophthalmologists.The pitiable funding of academic general prac- tice posts means that we are few to become involved in all aspects of specialist training; but most medical schools now have general practice departments more than willing to combine effort.These two articles exemplify just how important such cooperation should be.
Cocaine, Smoking, and Spontaneous Abortion
Authors: James L. Mills
Journal: New England Journal of Medicine (1999)

In 1991 the Senate Committee on Appropriations approached the National Institute of Child Health and Human Development with a request and an offer. The request was to design a definitive study to determine the effects of illicit drugs on pregnancy. The offer was substantial financial support to conduct the study. The response caused some surprise.1 My colleagues and I recommended that funds not be allocated because problems in identifying drug use, legal obstacles, privacy issues, and confounding as a result of other factors in women who abuse drugs made a definitive study extremely difficult if not impossible to conduct.Our . . .
Scintigraphic Manifestation of Fibrous Dysplasia
Authors: KIKUO MACHIDA, KOZO MAKITA, JUNICHI NISHIKAWA, TOHRU OHTAKE, MASAHIRO IIO
Journal: Clinical Nuclear Medicine (1986)

Scintigraphic manifestations of fibrous dysplasia were analyzed in 59 lesions of 26 patients (12 monostotic, 14 polystotic). Bone imaging with Tc-99m MDP revealed a high percentage of increased uptake of radioisotope in the lesions of fibrous dysplasia. Four (14%) of 29 cystic lesions and two (7%) of 30 lesions with the appearance of ground glass showed no increase in radioisotope uptake, although roentgenograms showed marked changes. Therefore, care must be taken in the diagnosis of fibrous dysplasia with bone imaging alone. Nuclear methods, however, are indispensable in evaluating the dynamic aspects of bone mineral behavior and in demonstrating disease where none was suspected, or in visualizing polyostotic involvement in those cases where only monostotic disease was suspected clinically. It is concluded that both scintigrams and roentgenograms are complementary procedures in the diagnosis of fibrous dysplasia.
Cercarial dermatitis contracted via contact with an aquarium: case report and review.
Authors: R. Folster-Holst, R. Disko, J. Rowert, W. Bockeler, I. Kreiselmaier, E. Christophers
Journal: British Journal of Dermatology (2001)

Journal Article Cercarial dermatitis contracted via contact with an aquarium: case report and review Get access R. Fölster‐Holst, R. Fölster‐Holst Department of Dermatology, Christian Albrechts University of Kiel, Schittenhelmstrasse 7, 24105 Kiel, Germany Dr R.Fölster‐Holst.E‐mail: rfoelsterholst@dermatology.uni‐kiel.de Search for other works by this author on: Oxford Academic Google Scholar R. Disko, R. Disko Institute of Medical Microbiology of the Technical University of Munich, Germany Search for other works by this author on: Oxford Academic Google Scholar J. Röwert, J. Röwert Department of Dermatology, Christian Albrechts University of Kiel, Schittenhelmstrasse 7, 24105 Kiel, Germany Search for other works by this author on: Oxford Academic Google Scholar W. Böckeler, W. Böckeler Institute of Zoology, University of Kiel, Germany Search for other works by this author on: Oxford Academic Google Scholar I. Kreiselmaier, I. Kreiselmaier Department of Dermatology, Christian Albrechts University of Kiel, Schittenhelmstrasse 7, 24105 Kiel, Germany Search for other works by this author on: Oxford Academic Google Scholar E. Christophers E. Christophers Department of Dermatology, Christian Albrechts University of Kiel, Schittenhelmstrasse 7, 24105 Kiel, Germany Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 145, Issue 4, 1 October 2001, Pages 638–640, https://doi.org/10.1046/j.1365-2133.2001.04414.x Published: 01 October 2001
IMPACT OF CONTRAST ENHANCED TRANS-ESOPHAGEAL ECHOCARDIOGRAPHY ON LEFT ATRIAL APPENDAGE THROMBUS EXCLUSION IN PATIENTS AWAITING DIRECT CURRENT CARDIOVERSION
Authors: Merrick Jay Donenberg, Jeremy Parker, Jonathan Kaplan, Jeffrey Soble, Melissa Tracy, Payman Sattar, Kousik Krishnan, Christopher Madias, Rami Doukky, Steven Feinstein
Journal: Journal of the American College of Cardiology (2014)
Long-term anticoagulant treatment after myocardial infarction.
Authors: C F Borchgrevink
Journal: BMJ (1970)

Placebo."If one compares the mean pre- treatment blood pressure with mean "placebo" blood pressure in Table 1 there is a fall in blood pressure of 26/9 mm.Hg which is very similar to our own results, 26/10 mm.Hg, when patients were receiving a diuretic alone.The authors consider various explanations for the failure of the blood pressure to rise to untreated levels when propranolol was stopped.As almost all were still on diuretic therapy during this time it would seem that no other explanation need be considered.The results presented in Fig. 1 of their paper suggest that the maximal effect of propranolol is seen in less than six weeks, and does not support their initial hypothesis that some trials have failed to show an effect of propranolol because the duration of treatment was not long enough.The authors say that they selected the 32 patients for study from more than 300 on the drug, the grounds of selection being that they had responded to propranolol in a dose of less than 320 mg.daily.If patients are selected for inclusion in a trial on the ground that they had already responded well to the drug the result is bound to be biased in favour of the drug under study, and no amount of care in trial design will eliminate this bias.-Weare, etc.,
An ERK-p38 Subnetwork Coordinates Host Cell Apoptosis and Necrosis during Coxsackievirus B3 Infection
Authors: Karin J. Jensen, Farshid S. Garmaroudi, Jingchun Zhang, Jun Lin, Seti Boroomand, Mary Zhang, Zongshu Luo, Decheng Yang, Honglin Luo, Bruce M. McManus, Kevin A. Janes
Journal: Cell Host & Microbe (2013)
REPORT CX. ON THE DIFFERENCE IN CONTENT OF IMMUNE SUBSTANCES IN BLOOD SERUM AND PLASMA
Authors: G. Dreyer, E. W. A. Walker
Journal: BMJ (1909)

<h3>Background</h3> Nut consumption has increased in the US but little evidence exists on the association between changes in nut consumption and weight change. We aimed to evaluate the association between changes in total consumption of nuts and intakes of different nuts (including peanuts) and long-term weight change, in three independent cohort studies. <h3>Methods and findings</h3> Data collected in three prospective, longitudinal cohorts among health professionals in the US were analysed. We included 27 521 men (Health Professionals Follow-up Study, 1986 to 2010), 61 680 women (Nurses’ Health Study, 1986 to 2010), and 55 684 younger women (Nurses’ Health Study II, 1991 to 2011) who were free of chronic disease at baseline in the analyses. We investigated the association between changes in nut consumption over 4-year intervals and concurrent weight change over 20–24 years of follow-up using multivariate linear models with an unstructured correlation matrix to account for within-individual repeated measures. 21 322 individuals attained a body mass index classification of obesity (BMI ≥30 kg/m<sup>2</sup>) at the end of follow-up. Average weight gain across the three cohorts was 0.32 kg each year. Increases in nut consumption, per 0.5 servings/day (14 g), was significantly associated with less weight gain per 4-year interval (p&lt;0.01 for all): −0.19 kg (95% CI -0.21 to -0.17) for total consumption of nuts, -0.37 kg (95% CI -0.45 to -0.30) for walnuts, -0.36 kg (95% CI -0.40 to -0.31) for other tree nuts, and -0.15 kg (95% CI -0.19 to -0.11) for peanuts. Increasing intakes of nuts, walnuts, and other tree nuts by 0.5 servings/day was associated with a lower risk of obesity. The multivariable adjusted RR for total nuts, walnuts, and other tree nuts was 0.97 (95% CI 0.96 to 0.99, p=0.0036), 0.85 (95% CI 0.81 to 0.89, p=0.0002), and 0.89 (95% CI 0.87 to 0.91, p&lt;0.0001), respectively. Increasing nut consumption was also associated with a lower risk of gaining ≥2 kg or ≥5 kg (RR 0.89–0.98, p&lt;0.01 for all). In substitution analyses, substituting 0.5 servings/day of nuts for red meat, processed meat, French fries, desserts, or potato, chips (crisps) was associated with less weight gain (p&lt;0.05 for all). Our cohorts were largely composed of Caucasian health professionals with relatively higher socioeconomic status; thus the results may not be generalisable to other populations. <h3>Conclusion</h3> Increasing daily consumption of nuts is associated with less long-term weight gain and a lower risk of obesity in adults. Replacing 0.5 servings/day of less healthful foods with nuts may be a simple strategy to help prevent gradual long-term weight gain and obesity.
Tubulointerstitial responses in the progression of glomerular diseases: Albuminuria modulates αvβ5 integrin
Authors: Licia Peruzzi, Livio Trusolino, Alessandro Amore, Bruno Gianoglio, Paola Cirina, Giuseppe Basso, Steven N. Emancipator, Pier Carlo Marchisio, Rosanna Coppo
Journal: Kidney International (1996)
Triage and patient safety in emergency departments
Authors: S. Oredsson
Journal: BMJ (2011)

Overcrowding calls for re-engineering of triage models and new patient flow processes 

The emergency department is the point of entry for more than half of all patients admitted to hospital care, primarily because of an increasingly elderly population. Recent reports also show that more teenagers and young adults are seeking medical care in the emergency department.1 This phenomenon is characterised by expectations of medical service on a 24/7 basis. Together, these changes contribute to overcrowded emergency departments that put patient safety at risk.2

Can these changes be reversed or prevented? Most countries have put much effort into educating patients to use primary care facilities in semi-emergency situations. In general these efforts have failed, especially in urban areas, leaving only one choice—to accept the fact that visits to the emergency department will continue to increase.3 Changes in the organisation of the emergency department are therefore needed to prevent an increase in care related injuries.

Triage was adopted in the 1980s to prevent seriously ill patients from dying while waiting their turn. However, evidence shows that traditional triage increases waiting times rather …
Contrast-enhanced doppler ultrasonography in the diagnosis of hepatocellular carcinoma and premalignant lesions in patients with cirrhosis
Authors: Anna Ludovica Fracanzani, Larry Burdick, Mauro Borzio, Massimo Roncalli, Nicola Bonelli, Franco Borzio, Alessandra Maraschi, Gemino Fiorelli, Silvia Fargion
Journal: Hepatology (2001)

Hepatocellular carcinogenesis in cirrhosis is a multistage process that includes large regenerative nodules, dysplastic nodules, and hepatocarcinoma. The aim of this study was to establish whether contrast-enhanced Doppler ultrasonography (US) is able to distinguish between early hepatocellular carcinoma (HCC) and small nonmalignant nodules in cirrhosis. Between January 1998 and December 1999, 500 cirrhotic patients with no previous history of HCC or evidence of hepatic focal lesions were enrolled and prospectively followed-up with US every 6 months until December 2000. Sixty-one patients developed focal lesions, 12 multifocal, and 49 monofocal. Biopsy of focal lesions, contrast-enhanced Doppler US, and spiral computed tomography (CT) were performed in 41 consecutive patients with small (<3 cm) monofocal lesions. Twenty nodules were diagnosed as HCC and 21 as nonmalignant (14 large regenerative nodules, 3 low-grade, and 4 high-grade dysplastic nodules) by liver biopsy. Intratumoral arterial blood flow was detected in 19 of 20 (95%) HCC and 6 of 21 (28%) nonmalignant nodules by contrast-enhanced Doppler US (P<.0001). The mean peak resistance and pulsatility indices were 0.82 +/- 0.09 and 1.56 +/- 0.2 in HCC and 0.62 +/- 0.08 and 0.82 +/- 0.08 in dysplastic lesions (P =.002 and.0001), respectively. Spiral CT revealed arterial perfusion in 19 of 20 HCC and in 4 of 21 nonmalignant nodules (high-grade dysplastic nodules). Four of the apparently false-positive nodules at enhanced Doppler US were high-grade dysplastic nodules and 2 evolved to HCC during follow-up. In conclusion, contrast-enhanced Doppler US is a noninvasive, very sensitive technique in differentiating malignant and premalignant lesions from nonmalignant focal lesions in the liver.
Laënnec vs. Laennec
Authors: George Halperin
Journal: JAMA (1961)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Hypoalbuminemia, Diarrhea, and the Acquired Immunodeficiency Syndrome
Authors: ROBERT R. BRINSON
Journal: Annals of Internal Medicine (1985)

Letters and Corrections1 March 1985Hypoalbuminemia, Diarrhea, and the Acquired Immunodeficiency SyndromeROBERT R. BRINSON, M.D.ROBERT R. BRINSON, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-102-3-413_1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: Kotler and associates (1) recently reported the first study of the gastrointestinal effects of the acquired immunodeficiency syndrome in a series of homosexual men. Although the authors discussed the possible infectious agents responsible for the high incidence of diarrhea and weight loss in these patients, no viral, bacterial, or parasitic infections could be identified.We have recently treated 35 patients admitted consecutively to the medical intensive care unit at University Hospital of Jacksonville, Jacksonville, Florida. Twelve patients developed diarrhea, all of whom had a serum albumin level of less than 2.5 g/dL. The remaining 23 patients maintained...References1. KOTLERGAETZLANGEKLEINHOLT DHMEP. Enteropathy associated with the acquired immunodeficiency syndrome. Ann Intern Med. 1984;101:421-8. LinkGoogle Scholar2. COBBCARTMILLGILSDORF LAR. Early postoperative nutritional support using the serosal tunnel jejunostomy. J Parenter Enter Nutr. 1981;5:397-401. CrossrefMedlineGoogle Scholar3. MOSS G. Malabsorption associated with extreme malnutrition: importance of replacing plasma albumin. J Am Coll Nutr. 1982;1:89-92. CrossrefMedlineGoogle Scholar4. GRANGERBARROWMAN DJ. Microcirculation of the alimentary tract: II. Pathophysiology of edema. Gastroenterology. 1983;84:1035-49. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByDiarrhea and Human Immunodeficiency Virus: A Possible Synergy for Clinical PracticeNutritional support in HIV infection and AIDSInfluence of HIV Infection on Vitamin Status and RequirementsMalnutrition in Patients with AIDSNutritional status of HIV-infected patients during the early disease stagesPosition of The American Dietetic Association: Nutrition intervention in the treatment of human immunodeficiency virus infectionResponse to Letter from Drs Brinson and PittsIncidence of Malnutrition in Patients With Acquired Immunodeficiency SyndromeNutritional Management of Patients with ARC or AIDSNutrition care of AIDS patientsDiarrhea in Tube-Fed Burn Patients: Incidence, Etiology, Nutritional Impact, and PreventionThe Acquired Immune Deficiency SyndromePLASMA PROTEIN ALTERATIONS IN AIDS AND HEMOPHILIA A 1 March 1985Volume 102, Issue 3Page: 413-413KeywordsAIDSDiarrheaHomosexualsMedical intensive care unitsParasitic diseasesSerum albuminWeight loss Issue Published: 1 March 1985 PDF DownloadLoading ...
HENRY BACHMAN STEHMAN
Authors: Norman Bridge
Journal: JAMA (1918)

<h3>To the Editor:</h3> —InThe Journal, February 23, you published an obituary of Dr. Henry B. Stehman of Los Angeles. It was very brief, and I fear that you did not do him justice. May I add an appreciation: Dr. Henry Bachman Stehman was a modest gentleman and yet a great man whose career as a citizen, physician and philanthropist was unique. His life calendar was brief: Born 1852; graduated Lebanon Valley College, 1873, receiving there his A.M. later; Universities of Leipzig and Brussels, 1873-1875; M.D., Jefferson, 1877. Internship in Blockley Hospital; married Miss Elizabeth Miller, 1881; superintendent, Presbyterian Hospital, Chicago, 1884, and retired by sickness, 1899. Moved to Pasadena. There he worked, handicapped by physical suffering, and died its most useful citizen. He was a man of vision, and whatever he undertook he did. He had a constructive mind, a genius for organization, which found scope in two hospitals,
CELL-MEDIATED IMMUNITY AND SUPPRESSOR-T-CELL DEFECTS TO LIVER-DERIVED ANTIGENS IN FAMILIES OF PATIENTS WITH AUTOIMMUNE CHRONIC ACTIVE HEPATITIS
Authors: C.J. O'Brien, P.T. Donaldson, I.G. Mcfarlane, S. Vento, ClaireG. Mcsorley, Roger Williams, A.L.W.F. Eddleston
Journal: The Lancet (1986)
Tumours: Structure and Diagnosis
Authors: Cyril Abrahams
Journal: JAMA (1992)

This book is a pathologist's delight. It is indeed a feat of the highest accomplishment to be able to produce over 2000 illustrations in color and with none that are out of focus, indistinct, or unclear. The book deals almost entirely with tumor pathology and gives examples of the commonest neoplastic lesions. It is very easy to navigate this work, as the sections are arranged by organ system. All photomicrographs are well illustrated with arrows and lettering. Furthermore, as a bonus, each illustration comes with a short description of the tumor and mentions distinguishing points to help make the correct diagnosis. The book follows the previous gross pathology atlas by these two accomplished pathologists and keeps up the high standard. As it is aimed at pathologists in training as well as experienced pathologists, it may be worthwhile, if the book ever reaches a second edition, to include a few extra
MULTIVARIABLE PREDICTORS OF CLINICAL RESTENOSIS, CARDIAC DEATH OR MYOCARDIAL INFARCTION TO 2 YEARS FOLLOWING EVEROLIMUS OR PACLITAXEL DRUG-ELUTING STENT DEPLOYMENT: THE SPIRIT II, III, IV AND COMPARE TRIAL EXPERIENCE
Authors: Dean J. Kereiakes, Pieter C. Smits, Elvin Kedhi, Helen Parise, Martin Fahy, Patrick W. Serruys, Gregg W. Stone
Journal: Journal of the American College of Cardiology (2011)
Intravenous tissue plasminogen activator and size of infarct, left ventricular function, and survival in acute myocardial infarction.
Authors: F. Van de Werf, A. E. Arnold
Journal: BMJ (1988)

STUDY OBJECTIVE--To assess effect of intravenous recombinant tissue type plasminogen activator on size of infarct, left ventricular function, and survival in acute myocardial infarction. DESIGN--Double blind, randomised, placebo controlled prospective trial of patients with acute myocardial infarction within five hours after onset of symptoms. SETTING--Twenty six referral centres participating in European cooperative study for recombinant tissue type plasminogen activator. PATIENTS--Treatment group of 355 patients with acute myocardial infarction allocated to receive intravenous recombinant plasminogen activator. Controls comprised 366 similar patients allocated to receive placebo. INTERVENTION--All patients were given aspirin 250 mg and bolus injection of 5000 IU heparin immediately before start of trial. Patients in treatment group were given 100 mg recombinant tissue plasminogen activator over three hours (10 mg intravenous bolus, 50 mg during one hour, and 40 mg during next two hours) by infusion. Controls were given placebo by same method. Full anticoagulation treatment and aspirin were given to both groups until angiography (10-22 days after admission). beta Blockers were given at discharge. END POINT--Left ventricular function at 10-22 days, enzymatic infarct size, clinical course, and survival to three month follow up. MEASUREMENTS AND MAIN RESULTS--Mortality was reduced by 51% (95% confidence interval -76 to 1) in treated patients at 14 days after start of treatment and by 36% (-63 to 13) at three months. For treatment within three hours after myocardial infarction mortality was reduced by 82% (-95 to -31) at 14 days and by 59% (-83 to -2) at three months. During 14 days in hospital incidence of cardiac complications was lower in treated patients than controls (cardiogenic shock, 2.5% v 6.0%; ventricular fibrillation, 3.4% v 6.3%; and pericarditis, 6.2% v 11.0% respectively), but that of angioplasty or artery bypass, or both was higher (15.8% v 9.6%) during the first three months. Bleeding complications were commoner in treated than untreated patients. Most were minor, but 1.4% of treated patients had intracranial haemorrhage within three days after start of infusion. Enzymatic size of infarct, determined by alpha hydroxybutyrate dehydrogenase concentrations, was less (20%, 2p = 0.0018) in treated patients than in controls. Left ventricular ejection fraction was 2.2% higher (0.3 to 4.0) and end diastolic and end systolic volumes smaller by 6.0 ml (-0.2 to -11.9) and 5.8 ml (-0.9 to -10.6), respectively, in treated patients. CONCLUSION--Recombinant tissue type plasminogen activator with heparin and aspirin reduces size of infarct, preserves left ventricular function, and reduces complications and death from cardiac causes but at increased risk of bleeding complications4+
Helicobacter pylori and its interaction with risk factors for chronic disease
Authors: D. J A Jenkins
Journal: BMJ (1997)

In this issue Brenner and colleagues document the effects of lifestyle on Helicobacter pylori infection in 447 patients in a German rural practice (p 1489).1 They found that the H pylori infection rate appeared to be reduced by alcohol consumption (≥3 cups per day), and non-significantly increased by smoking. In the past, when idiopathic gastric hyperacidity was considered to be the chief cause of dyspeptic symptoms, smoking, coffee, and alcohol were often implicated as exacerbating the condition and advice given to eliminate these habits. Increasingly since 1984, however, when Warren and Marshall hypothesised that campylobacter-like organisms were the cause of peptic ulcer disease,2 there has been a need to re-evaluate the role of these traditional risk factors. This need has been addressed by Brenner et al with some seemingly unexpected results.

There are reasons why alcohol, coffee, and smoking might have little effect on, or even increase, the hostility of the gastric environment to H …