OBSERVATIONS ON THE PATHOGENESIS, COURSE AND TREATMENT OF NONOBSTRUCTIVE PYELONEPHRITIS
Authors: H D BRAINERD, L M CECIL
Journal: Annals of Internal Medicine (1956)

Article1 August 1956OBSERVATIONS ON THE PATHOGENESIS, COURSE AND TREATMENT OF NONOBSTRUCTIVE PYELONEPHRITISH. D. BRAINERD, M.D., F.A.C.P., L. M. CECIL, M.D.H. D. BRAINERD, M.D., F.A.C.P.Search for more papers by this author, L. M. CECIL, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-45-2-232 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe importance of pyelonephritis as a cause of illness and death has only recently become fully appreciated. Not only are infections of the urinary tract second in frequency to those of the respiratory tract, but also they commonly lead to serious or fatal sequelae. Longcope and Winkenwerder1first emphasized the rôle of chronic pyelonephritis in the production of malignant hypertension. Their observations were further expanded by those of Weiss and Parker,2who also suggested the relationship of chronic or healed pyelonephritis to both benign and malignant hypertension. Pyelonephritis, active or healed, is found in 14 to 20% of autopsies.2-4Furthermore,...Bibliography1. LongcopeWinkenwerder WTWC: Clinical features of the contracted kidney due to pyelonephritis, Bull. Johns Hopkins Hosp. 53: 255, 1933. Google Scholar2. WeissParker SF: Pyelonephritis: its relation to vascular lesions and arterial hypertension, Medicine 18: 221, 1939. CrossrefGoogle Scholar3. MansfieldMalloryEllis JSGKLB: The differential diagnosis of Bright's disease: clinicopathological correlation, New England J. Med. 229: 387, 1943. CrossrefGoogle Scholar4. RhoadsBillingsO'Conor PSCEVJ: Antibacterial management of urinary tract infections, J. A. M. A. 148: 165 (Jan. 19) 1952. CrossrefMedlineGoogle Scholar5. JacksonDallenbachKipnis GGFDGP: Pyelonephritis. Correlation of clinical and pathologic observations in the antibiotic era, M. Clin. North America 39: 297, 1955. CrossrefGoogle Scholar6. PetersLavietesZimmerman JPPHHM: Pyelitis in toxemias of pregnancy, Am. J. Obst. and Gynec. 32: 911, 1936. CrossrefGoogle Scholar7. Finnerty FA: Toxemia of pregnancy as seen by an internist, Ann. Int. Med. 44: 358, 1956. LinkGoogle Scholar8. CecilBrainerdClarkScaparone LMHRM: Experimental pyelonephritis of the rabbit. I. Method of production and the natural course of acute "non-obstructive" pyelonephritis, Stanford Med. Bull. 13: 544, 1955; Clin. Res. Proc. 4: 66, 1956. Google Scholar9. Kass EH: Chemotherapeutic and antibiotic drugs in the management of infections of the urinary tract, Am. J. Med. 18: 764, 1955. CrossrefMedlineGoogle Scholar10. Scott WW: Blood stream infections in urology; report of 82 cases, J. Urol. 21: 527, 1929. CrossrefGoogle Scholar11. Young HH: Renal infections associated with prostatic obstruction, Bull. Johns Hopkins Hosp. 53: 1, 1933. Google Scholar12. SpittelMartinNichols JAWJDR: Bacteremia owing to gram-negative bacilli: experiences in the treatment of 137 patients in a 15-year period, Ann. Int. Med. 44: 302, 1956. LinkGoogle Scholar13. CecilBrainerdLoebScaparone LMHSM: Experimental pyelonephritis of the rabbit. III. Observations on pathogenesis. In preparation. Google Scholar14. HelmholzBeeler , quoted by Kennedy.18 Google Scholar15. Brewer GE: The present state of our knowledge of acute renal infections, J. A. M. A. 57: 179, 1911. CrossrefGoogle Scholar16. BraudeShapiroSimienski AIAPJ: Hematogenous pyelonephritis in rats. I. Its pathogenesis when produced by a simple new method, J. Clin. Investigation 34: 1489, 1955. CrossrefMedlineGoogle Scholar17. GuyonAlbarran , quoted by Brewer.15 Google Scholar18. Kennedy RL: The pathologic changes in pyelitis of children interpreted on the basis of experimental lesions, J. Urol. 27: 371, 1932. CrossrefGoogle Scholar19. BrainerdCecilLoebScaparone HLMSM: Experimental pyelonephritis of the rabbit. IV. The late sequelae of pyelonephritis. In preparation. Google Scholar20. CecilBrainerdClarkScaparone LMHRM: Experimental pyelonephritis of the rabbit: II. Effects of treatment of acute "nonobstructive" pyelonephritis with streptomycin and oxytetracycline. In preparation. Google Scholar21. HopperJawetzHinman JEF: Polymyxin B in chronic pyelonephritis, Am. J. M. Sc. 225: 402, 1953. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: San Francisco, California*Presented at the Thirty-seventh Annual Session of The American College of Physicians, Los Angeles, California, April 16, 1956.From the Infectious Disease Laboratory of the San Francisco Hospital, and the Department of Medicine, University of California School of Medicine, San Francisco.†Giannini Fellow in Medicine.Requests for reprints should be addressed to Henry Brainerd, M.D., Department of Medicine, University of California School of Medicine, San Francisco-22, California. 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Persistence of Normal Renal Structure and FunctionProlonged Treatment of Urinary-Tract Infections with Sulfamethoxypyridazine�ber die Staphylokokken-Pyelonephritis als h�ufigste Komplikation von Staphylodermien im S�uglingsalter 1 August 1956Volume 45, Issue 2Page: 232-241KeywordsHospital medicineHypertensionInfectious diseasesPathogenesisPathogensPyelonephritisResearch laboratoriesRespiratory systemUpper respiratory tract infectionsUrinary tract infections ePublished: 1 December 2008 Issue Published: 1 August 1956 PDF downloadLoading ...