DIABETES AND PANHYPOPITUITARISM
Authors: B ROTHFELD, J M RODAS
Journal: Annals of Internal Medicine (1954)

Case Reports1 July 1954DIABETES AND PANHYPOPITUITARISMBEN ROTHFELD, M.D., J. M. RODAS, M.D.BEN ROTHFELD, M.D.Search for more papers by this author, J. M. RODAS, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-41-1-140 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptINTRODUCTIONThe syndrome of panhypopituitarism was first clearly defined in 1914 by Simmonds.1He felt that the pathogenesis of this disease post partum was due to the embolic occlusion of the arterial blood supply, with resultant ischemic necrosis of the pituitary. That this was not the true pathogenesis was shown by Sheehan in a series of papers.2-4In these papers he proved that the etiology in cases developing post partum was that the blood supply of the gland after delivery is normally reduced rapidly. If further reduced by circulatory collapse the blood flow may reach an extremely low level. Thrombosis...Bibliography1. Simmonds M: Über Hypophysisschwund mit tödlichem Ausgang, Deutsche med. Wchnschr. 40: 322-323 (Feb.) 1914. CrossrefGoogle Scholar2. Sheehan HL: Postpartum necrosis of the anterior pituitary, J. Path. and Bact. 45: 189-214 (July) 1947. CrossrefGoogle Scholar3. Sheehan HL: Postpartum necrosis of anterior pituitary. Pathological and clinical aspects, J. Obst. and Gynec. Brit. Emp. 45: 456-489 (June) 1938. CrossrefGoogle Scholar4. Sheehan HL: Simmonds' disease due to post-partum necrosis of the anterior pituitary, Quart. J. Med. 8: 277-309 (Oct.) 1939. Google Scholar5. SheehanSummers HLK: The syndrome of hypopituitarism, Quart. J. Med. 18: 319-378 (Oct.) 1949. MedlineGoogle Scholar6. Calder RM: Anterior pituitary insufficiency (Simmonds' disease), Bull. Johns Hopkins Hosp. 50: 87, 1932. Google Scholar7. LyallInnes AJA: Diabetes mellitus and the pituitary gland: a case of diabetes with intercurrent pituitary lesion and concomitant improvement of diabetes, Lancet 1: 318, 1935. CrossrefGoogle Scholar8. KotteVonderahe JHAR: The Houssay phenomenon in man: a case of diabetes mellitus, infarct of anterior pituitary and terminal hypoglycemia, J. A. M. A. 114: 950, 1940. Google Scholar9. FeldmanRobertsSisselmanLipetz FJBSB: Coincidence of diabetes mellitus and hypopituitarism, Arch. Int. Med. 79: 322-332 (Mar.) 1947. CrossrefGoogle Scholar10. VandenbroeckFerin JJ: L'influence de l'insuffisance hypophysaire sur le cours du diabetique pancreatique. Une observation humaine. Les effets de la gonadotrophine serique d'origine equine chez la femme, Ann. d'endocrinol. 8: 366-369, 1947. Google Scholar11. MarzulloHandelsman ERMB: Pituitary necrosis and diabetes mellitus, J. Clin. Endocrinol. 11: 537-547 (May) 1951. CrossrefGoogle Scholar12. Williams FW: Pituitary necrosis in diabetic during pregnancy, Diabetes 1: 37-40 (Jan.) 1952. CrossrefMedlineGoogle Scholar13. de BodoKurtzAncowitzKiang RCMASP: Loss of insulin hypersensitivity and development of diabetes in hypophysectomized dogs produced by purified growth hormone, Proc. Soc. Exper. Biol. and Med. 74: 524-526 (July) 1950. CrossrefMedlineGoogle Scholar14. MayerSilides JD: A quantitative method of determination of the diabetogenic activity of growth hormone preparations, Endocrinology 52: 54-56 (Jan.) 1953. CrossrefMedlineGoogle Scholar15. Young FG: Banting Memorial Lecture: Endocrine approach to problem of diabetes, Proc. Am. Diabetes A. 10: 11-22, 1950. Google Scholar16. Houssay BA: Carbohydrate metabolism, New England J. Med. 214: 971-982 (May) 1936. CrossrefGoogle Scholar17. Selye H: Textbook of endocrinology, 1949, Univ. de Montreal, p. 206-207. Google Scholar18. Williams RH: Textbook of endocrinology, 1950, Saunders, Philadelphia, p. 16-17. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Perry Point, Maryland*Received for publication January 5, 1954.From the Medical Service, Veterans Administration Hospital, Perry Point, Maryland.Published with permission of the Chief Medical Director, Department of Medicine and Surgery, Veterans Administration, who assumes no responsibility for the opinions expressed or conclusions drawn by the authors. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byHormonal Diabetes Secondary to Extrapancreatic EndocrinopathiesHormonal DiabetesThe Coincidence of Diabetes Mellitus and Pituitary InsufficiencyAmelioration of Diabetes Mellitus after Pituitary InfarctionThe Houssay phenomenon in man 1 July 1954Volume 41, Issue 1Page: 140-146KeywordsBloodBlood flowEtiologyMedical servicesNecrosisPanhypopituitarismPathogenesisSurgeryThrombosis ePublished: 1 December 2008 Issue Published: 1 July 1954 PDF downloadLoading ...