tbuckley/cabot-search huggingface dataset:
P2-01-16: Dissecting the Cellular Mechanism of Induction and Sustenance of Dormancy by Rho GTPases in Breast Cancer.
Authors: M Chatterjee, Golen KL van
Journal: Cancer Research (2011)

Abstract Tumor dormancy has been a very real problem in breast cancer survivors where recurrences are common and usually fatal. Molecular mechanisms involved in this process are often poorly understood and are a hot spotin breast cancer research today. We have found that Rho GTPases, specifically RhoC, is hyperactivated in low metastatic dormant breast tumor cells while RhoA is downregulated. We also found RhoC causes phosphorylation of c-jun NH2 terminal kinase (JNK) in these cells which in turn activates the process of autophagy, a possible mode of cell survival in dormant tumor cells. Modulating RhoC affected phosphorylation of JNK. Also, abrogating JNK by a pharmacological inhibitor SP600125 inhibited expression of the autophagy marker LC3B-II. Autophagy genes like Atg 5 and Atg 12 were expressed along with the autophagy marker LC3B-II. On inhibiting autophagy by a specific inhibitor 3-Methyladenine (3-MA), cells did not readily undergo apoptosis but on stressing them doubly with LY294002, an inhibitor of Class I PI3K, along with 3-MA (inhibitor of Class III PI3K), significant number of dormant cells underwent apoptosis as observed by TUNEL staining. We also found that p190RhoGAP was activated in these dormant cells which may lead to the observed downregulation of RhoA activation levels. Involvement of beta-1 integrin along with c-src in activation of RhoC was observed in these dormant cells. We are in the process of further elucidating these signal transduction processes that might be involved in cellular dormancy of breast cancer. A better understanding of some of the cellular mechanisms of induction and sustenance of dormancy may aid in formulating therapies for annihilating these dormant tumor cells thus preventing the often fatal relapses in breast cancer survivors. Citation Information: Cancer Res 2011;71(24 Suppl):Abstract nr P2-01-16.
Dietary Fat Intake and Risk of Epithelial Ovarian Cancer
Authors: H. A. Risch, M. Jain, L. D. Marrett, G. R. Howe
Journal: JNCI Journal of the National Cancer Institute (1994)

Journal Article Dietary Fat Intake and Risk of Epithelial Ovarian Cancer Get access Harvey A. Risch, Harvey A. Risch Department of Epidemiology and Public Health, Yale University School of MedicineNew Haven, Conn. Correspondence to : Harvey A. Risch, M.D., Ph.D., Department of Epidemiology and Public Health, Yale University School of Medicine, 60 College St., P.O. Box 3333, New Haven, CT 06510. Search for other works by this author on: Oxford Academic PubMed Google Scholar Meera Jain, Meera Jain National Cancer Institute of Canada Epidemiology Unit, Department of Preventive Medicine and Biostatistics, University of TorontoOntario, Canada Search for other works by this author on: Oxford Academic PubMed Google Scholar Loraine D. Marrett, Loraine D. Marrett Ontario Cancer Treatment and Research FoundationToronto Search for other works by this author on: Oxford Academic PubMed Google Scholar Geoffrey R. Howe Geoffrey R. Howe National Cancer Institute of Canada Epidemiology Unit, Department of Preventive Medicine and Biostatistics, University of TorontoOntario, Canada Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 86, Issue 18, 21 September 1994, Pages 1409–1415, https://doi.org/10.1093/jnci/86.18.1409 Published: 21 September 1994 Article history Received: 21 January 1994 Revision received: 02 June 1994 Accepted: 29 June 1994 Published: 21 September 1994
Enhanced Excitatory Transmission at Cortical Synapses as the Basis for Facilitated Spreading Depression in CaV2.1 Knockin Migraine Mice
Authors: Angelita Tottene, Rossella Conti, Alessandra Fabbro, Dania Vecchia, Maryna Shapovalova, Mirko Santello, Arn M.J.M. van den Maagdenberg, Michel D. Ferrari, Daniela Pietrobon
Journal: Neuron (2009)
Ribavirin enhances the efficacy but not the adverse effects of interferon in chronic hepatitis C
Authors: Solko W. Schalm, Bettina E. Hansen, Liliana Chemello, Antonio Bellobuono, Johannes T. Brouwer, Ole Weiland, Luisa Cavalletto, Robert Schvarcz, Gaetano Ideo, Alfredo Alberti
Journal: Journal of Hepatology (1997)
Abstract 3074: NAD(P)H:quinone oxidoreductase 1 stabilizes C/EBPα from 20S proteasomal degradation leading to protection against myeloproliferative disease
Authors: Junkang Xu, Anil Jaiswal
Journal: Cancer Research (2012)

Abstract NAD(P)H:quinone oxidoreductase 1 (NQO1) is a flavoprotein that protects cells against radiation and chemical induced oxidative stress. Disruption of NQO1 gene in mice leads to α-radiation-induced myeloproliferative disease. In the present study, we demonstrate that myeloid differentiation factor C/EBPα is degraded by 20S proteasome, and that NQO1 could salvage C/EBPα from 20S proteasomal degradation. Coimmunoprecipitation studies showed that NQO1, C/EBPα and 20S all interacted with each other. Deletion and site-directed mutagenesis studies demonstrated that NQO1 and 20S competed for the same binding region in C/EBPβ. Mutagenesis study also revealed that NQO1Y127/Y129 required for NADH binding is essential for NQO1 stabilization of C/EBPβ. Exposure of mice and HL-60 cells to α-radiation led to increased NQO1 and decreased 20S interaction with C/EBPβ, which resulted in stabilization of C/EBPα and protection against α-radiation-induced myeloproliferative diseases. This mechanism might provide day-to-day protection to bone marrow against adverse effects of radiation and chemical exposure, which has significant effect on individuals carrying hetero- or homozygous NQO1P187S mutation. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 103rd Annual Meeting of the American Association for Cancer Research; 2012 Mar 31-Apr 4; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2012;72(8 Suppl):Abstract nr 3074. doi:1538-7445.AM2012-3074
903-9 Effectiveness of Recombinant Hirulog ® in Reducing Restenosis After Balloon Angioplasty in the Atherosclerotic Rabbit
Authors: Leonard M. Thome, S. David Gertz, Lawrence W. Gimple, Kyle W. McCoy, Eric R. Powers, John M. Maraganore, Ian J. Sarembock
Journal: Journal of the American College of Cardiology (1995)
Aspergillus pseudomembranous necrotizing tracheitis
Authors: Xiuning Le, Preetesh Jain, Susan O'Brien
Journal: American Journal of Hematology (2012)

A 35-year-old female received multiagent induction chemotherapy including corticosteroids for acute lymphoblastic leukemia. Around day 20 of her chemotherapy, she developed progressive dry cough, low-grade fever, and hoarseness. It appeared that she has a foreign body in her throat. However, her sputum culture grew Aspergillus terrus. Computed tomographic imaging of her chest revealed circumferential thickening of trachea and left main stem bronchus with endoluminal densities compatible with sloughed-off material (Image 1, arrow). Under bronchoscopic examination, a large white necrotic but firm pseudomembrane was found to obstruct the trachea up to 80% (Image 2) and the pseudomembranous mass was removed. Histopathology of the tissue confirmed extensive deposition of fungal-hyphae. Aspergillus necrotizing tracheitis is a rare but life-threatening infection that affects immunosuppressed patients. 1 This condition is seen with Aspergillus fumigatus. Patients with acute leukemia are also severely immunosuppressed and a strong clinical suspicion of this unusual infection can be life saving for a patient. There are very few reports of Aspergillus pseudomembranous necrotizing tracheitis in acute leukemia patients. 2, 3 Our patient received intravenous voriconazole and G-CSF to aid the recovery. A repeat computed tomographic imaging showed decreased thickening of tracheal wall; therefore, she was discharged for follow-up in the clinic.
Aortic occlusion in systemic lupus erythematosus associated with antiphospholipid antibodies.
Authors: P Drew, R A Asherson, R J Zuk, F J Goodwin, G R Hughes
Journal: Annals of the Rheumatic Diseases (1987)

The patient, a Caucasian woman of 22 years, developed malignant hypertension at the age of 16 years. An abdominal bruit was found on routine examination. She had two spontaneous abortions and systemic lupus erythematosus was diagnosed at age 21 years. She was found to have a persistently low positive VDRL and antibodies to mitochondria were also present on repeated examinations, to a titre of 1/160. Because of angiographic findings, demonstrating an occlusion of the aorta, an endarterectomy of the descending thoracic and upper abdominal aorta was performed. This showed mainly intimal thickening and the presence of thrombus. She then had four further spontaneous abortions (with good blood pressure control). The lupus anticoagulant and antibodies to cardiolipin were found to be positive at this time.
Plastic foam neck support.
Authors: P. Harris
Journal: BMJ (1966)

Study of the LiverHashimoto's thyroiditis and rheumatoid arthritis, pointing out that it was not sur- prising that some of their patients with cir- rhosis had polyarthralgia, rashes, raised gammaglobulin levels, and positive cyto- plasmic antibodies.The lupus-erythematosus-cell phenomenon was noted in two out of seven patients.
A CONTRIBUTION FOR DEFINITE AND KNOWN QUANTITY AND QUALITY IN MINERAL WATERS.Read by title at the Meeting of the Mississippi Valley Medical Association, Oct. 14, 15 and 16, 1891, held at St. Louis, Mo.
Authors: GEO. F. HULBERT
Journal: JAMA (1891)

As medical science steps forward in her ceaseless stride for more and better understanding of disease in the human economy, so too is the desire and necessity created for better and more efficient means of relief. The study and use of the armamentarium at our command for this purpose has gradually and steadily brought before us that exceedingly valuable class of remedies known as mineral waters. Nature, in her beneficial and bounteous provision for the wants of mankind, has herein provided a weapon of defense, which, unfortunately, has not commanded the special attention of the profession<i>en masse</i>, but has been accepted and utilized by only the few. Why this has been so is easily understood. 1. The presentation of the character and value of mineral waters has only too frequently been in the lines of the charlatan and unscientific, advertised by those interested in a reckless, catchpenny style, and
Survival Benefit of Neoadjuvant Chemotherapy in Non-small Cell Lung Cancer: An Updated Meta-Analysis of 13 Randomized Control Trials
Authors: Wei-An Song, Nai-Kang Zhou, Wei Wang, Xiang-Yang Chu, Chao-Yang Liang, Xiao-Dong Tian, Jun-Tang Guo, Xi Liu, Yang Liu, Wei-Min Dai
Journal: Journal of Thoracic Oncology (2010)
TCT-461 Isolated Left-Anterior-Descending Artery In-stent Restenosis: Comparison Between Treatment With PCI-DES And CABG With Left-Internal-Mammary Artery
Authors: Dennis Zavalloni, Margherita Soldi, Giuseppe Ferrante, Marco G. Mennuni, Gabriele Luigi Gasparini, Paolo Pagnotta, Marco L. Rossi, Patrizia Presbitero
Journal: Journal of the American College of Cardiology (2013)
Standard Clinical Practice of Folfirinox in Advanced/Metastatic Pancreatic Cancer (Pc) Patients: A Canadian Registry
Authors: Maroun Jean, Ko Yoo-Joung, Ghafoor Akmal, Cripps Christine, Jonker Derek, Goel Rakesh, Asmis Tim, Goodwin Rachel, Tsvetkova Elena, Marginean Horia
Journal: Annals of Oncology (2014)
AN ELECTROENCEPHALOGRAPHIC AND CLINICAL STUDY OF CHILDREN WITH PRIMARY BEHAVIOR DISORDERS
Authors: JAMES P. CATTELL, BERNARD L. PACELLA
Journal: American Journal of Psychiatry (1950)

1. The literature pertaining to EEG and clinical studies of children with behavior disorders is reviewed and special attention is given to techniques of recording and evaluating EEGs, diagnostic classification of children, and the findings of various investigators. 2. A manual counting technique for EEG evaluation is described. 3. EEG and clinical studies of 42 boys in the age range of 6-12 are presented, including 20 children with neurotic traits, 16 with conduct type disorder, and 6 childhood schizophrenics. Evaluation of EEGs by frequency counting and "inspection" methods is reported with attention to hyperventilation response. Clinical data concerning family history of mental illness, type of home care and parental attention, history of significant illness and injury, presence of enuresis, fire-setting, and stealing as well as intelligence quotients are presented. Relationship of this material to clinical classification and EEG normality or abnormality is presented. 4. There is a discussion of the clinical and theoretical significance of this material.
A pilot phase II study of the safety and immunogenicity of HIV p17/p24:VLP (p24-VLP) in asymptomatic HIV seropositive subjects
Authors: B.S. Peters, R. Cheingsong-Popov, D. Callow, R. Foxall, G. Patou, K. Hodgkin, J.N. Weber
Journal: Journal of Infection (1997)
The transcription factor Spi-B is expressed in plasmacytoid DC precursors and inhibits T-, B-, and NK-cell development
Authors: Remko Schotte, Marie-Clotilde Rissoan, Nathalie Bendriss-Vermare, Jean-Michel Bridon, Thomas Duhen, Kees Weijer, Francine Brière, Hergen Spits
Journal: Blood (2003)
Impaired angiotensin II regulation of renal C-type natriuretic peptide mRNA expression in experimental diabetes mellitus
Authors: Thomas Walther, Heinz-Peter Schuitheiss, Carsten Tschöpe
Journal: Cardiovascular Research (2001)

Abnormalities in the regulation of natriuretic peptides (NP) associated with major diseases such as hypertension, heart failure, and diabetes mellitus (DM) have been reported. We investigated levels of mRNA for the vasodilator C-type natriuretic peptide (CNP) in the renal cortex of streptozotocin (STZ)-diabetic rats and the influence of an angiotensin II inhibition.DM was induced in Wistar rats by a single STZ injection. Rats were kept for 12 weeks. Additionally, the influence of the ACE inhibitor ramipril (Ram: 3 mg/kg/day) and the AT1 receptor antagonist losartan (Los: 20 mg/kg/day) on CNP expression in the STZ-diabetic and control groups was studied (each group n=6). Animals were characterized by their mean arterial blood pressure, plasma glucose levels, and renal function (each group n=9). After extraction of total renal cortical RNA, CNP expression was analyzed by Northern blots.Renal function was impaired in STZ-diabetic rats which has been improved by Ram and Los treatment. Untreated STZ-diabetic rats showed no difference in renal CNP expression compared to untreated controls. Ram and Los treatments led to an increase in renal cortical CNP mRNA in both diabetic and non-diabetic rats. This effect was weaker in STZ-diabetic rats (Ram: control 5.4-fold, STZ 3.5-fold; Los: control 4.2-fold, STZ 1.9-fold).These results clearly demonstrate a direct regulatory effect of the renin-angiotensin system (RAS) on renal mRNA levels of CNP. We suggest that RAS inhibition not only prevents the generation of angiotensin II (AngII) but also leads to a stimulation of CNP expression. We conclude that AngII suppresses CNP expression via the AT1 receptor and this mechanism is impaired in STZ-diabetic rats.
Medical Malpractice Crisis
Authors: Robert E. Cline, Carl J. Pepine
Journal: Circulation (2004)

s summarized in several previous Circulation Mini-Reviews 1-3 and elsewhere, 4 the United States is experiencing a growing deficit in cardiovascular physicians that is made worse as cardiovascular diseases become more prevalent.Important contributors to this deficit in the cardiovascular workforce and other specialty workforces are the high and rising costs of malpractice premiums in the majority of our states. 5As cardiovascular specialists in Florida (cardiothoracic surgery and cardiology), we are at the center of this crisis.In the present review, we will examine the problem along with recent activities related to this crisis in Florida and discuss their implications.
History of the Section on Radiology
Authors: J. P. Medelman
Journal: JAMA (1961)

THE HONOR that was given to me by being chosen as Chairman of the Section on Radiology for the current year is humbly and deeply appreciated. My gratitude for the distinction stems greatly from the opportunities that have come over the past several years for association with colleagues who are genuinely concerned with the advancement of radiology as a part of the practice of medicine. Their dedication has been always in accordance with ethical and scientific standards of excellence. If we are to be so fortunate as to continue with the type of leadership demonstrated by our predecessors and immediate successors, it is inevitable that our usefulness to the medical and general public will grow to a stage of importance only faintly sensed at this point. I do not mean to say that we should take credit for initiating a new era. We represent the bridge between eras and we
Abstract 5313: Phosphoproteomic analysis with reverse phase protein array identifies N-myc downstream regulated gene 1 (NDRG1) as a biomarker of phosphatidylinositol-3-kinase (PI3K)α inhibitor activity in a PTEN-deficient glioma cell line
Authors: Takeomi Inoue, Naoko Iwata, Eiji Nishiwaki, Yasuyuki Kirii
Journal: Cancer Research (2014)

Abstract Aberrant activation of phosphoinositide 3-kinase (PI3K) signaling is commonly reported in cancer, and leads to deregulation of several intracellular processes, including cell survival, growth, proliferation and migration. PI3K activates AKT, serum/glucocorticoid regulated kinase (SGK), phosphoinositide -dependent kinase 1 (PDK1), mammalian target of rapamycin (mTOR), and several other molecules involved in cell progression and survival. Reports have also indicated that the deletion of the gene encoding the tumor suppressor phosphatase and tensin homologue (PTEN) is one of the key factors controlling activation of the PI3K pathway. Glioblastoma (GBM), the most common malignant brain tumor in adults, represents a compelling disease for kinase inhibitor therapy. Although many therapies to target the Ras-PI3K-mTOR axis in GBM have been attempted, their efficacies have not been pronounced, presumably because of the complexity of PI3K mediated signaling. To elucidate the role of PTEN in PI3K signaling, the phosphorylation status of two glioma cell lines, LN229 (wild type PTEN) and U-87 MG (PTEN deficient) was investigated with phosphoproteomic reverse phase protein array (RPPA). When basal phosphorylation was compared between both cell lines, the phosphorylation of N-myc downstream regulated gene 1 (NDRG1) (Thr346), a physiological substrate of SGK1, was increased in U-87 MG cells compared with levels in LN229 cells. These data suggest that PTEN deletion affects the phosphorylation status of NDRG1 in U-87 MG cells. Following treatment with PIK-90, a PI3Kα inhibitor, phosphorylation of Akt (Ser473) and its direct substrate PRAS40 (Thr246) were decreased in both cell lines, however, NDRG1 (Thr346) phosphorylation was strongly inhibited only in U-87 MG cells. These results suggest that the differential effects of PIK-90 on LN229 and U-87 MG cells is PTEN dependent, and that detecting NDRG1 (Thr346) phosphorylation could be a biomarker for PI3Kα inhibitor treatment in PTEN deleted cancer cells. Ongoing studies are focusing on elucidating the mechanism of action of PIK-90 in glioma cell lines. Citation Format: Takeomi Inoue, Naoko Iwata, Eiji Nishiwaki, Yasuyuki Kirii. Phosphoproteomic analysis with reverse phase protein array identifies N-myc downstream regulated gene 1 (NDRG1) as a biomarker of phosphatidylinositol-3-kinase (PI3K)α inhibitor activity in a PTEN-deficient glioma cell line. [abstract]. In: Proceedings of the 105th Annual Meeting of the American Association for Cancer Research; 2014 Apr 5-9; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2014;74(19 Suppl):Abstract nr 5313. doi:10.1158/1538-7445.AM2014-5313
Clinical examination for non-cephalic presentation: Royal College of Midwives' response to research
Authors: Sue Macdonald
Journal: BMJ (2006)

EDITOR—Nassar et al conclude that a third of breech pregnancies are missed using abdominal palpation.1 The Royal College of Midwives recommends caution before using this research to advocate more reliance on technological solutions rather than clinical examination.

This study was carried out in Australia, where antenatal care practices are different from those …
microRNA-155 Regulates the Generation of Immunoglobulin Class-Switched Plasma Cells
Authors: Elena Vigorito, Kerry L. Perks, Cei Abreu-Goodger, Sam Bunting, Zou Xiang, Susan Kohlhaas, Partha P. Das, Eric A. Miska, Antony Rodriguez, Allan Bradley, Kenneth G.C. Smith, Cristina Rada, Anton J. Enright, Kai-Michael Toellner, Ian C.M. MacLennan, Martin Turner
Journal: Immunity (2007)
OC-044 Gastroscopy rate in English general practice populations: association with outcome for oesophagogastric cancer
Authors: M Shawihdi, G Powell, N Stern, N Kapoor, R Sturgess, E Thompson, M Pearson, K Bodger
Journal: Gut (2012)

<h3>Introduction</h3> Rates of gastroscopy vary between English general practice populations. The magnitude of this variation suggests a wide spectrum of clinical practice. Current guidelines focus on alarm symptoms as triggers for investigation but early symptoms of cancer are non-specific. This project aimed to determine whether overall gastroscopy rate in GP practice populations in England is associated with outcome of oesophagogastric cancer (OGC), as measured by rate of major surgical resection, emergency admission for cancer diagnosis and mortality. <h3>Methods</h3> Analysis of Hospital Episode Statistics (HES, 2006–2008) linked to death registry and practice population data. <b>Gastroscopy volume</b> determined by extracting total diagnostic gastroscopy procedures and aggregated at GP practice level. <b>OGC cases:</b> Methods developed and validated (using local &amp; national audit) to identify new cases of OGC and then extract all hospital episodes in chronological order, flag key milestones (eg, diagnostic gastroscopy; emergency admission to hospital; major surgery) using relevant diagnostic and procedure codes. <b>Entry criteria:</b> General practices with ≥1 new case of OGC and with a per capita gastroscopy rate within a valid reference range (0.4–4.0 per 1000 population). Practices grouped into tertiles (low, medium and high gastroscopy rate). <h3>Results</h3> 20 709 OGC cases from 5956 practices serving an adult population of 35.1 million. Characteristics of OGC cases matched the national audit findings. Cases registered with practices in lowest tertile of gastroscopy rate had lowest rate of surgery (14% vs 16% vs 16%; p=0.028), highest rate of emergency admission (29% vs 27% vs 25%; p&lt;0.01), and highest mortality at 6 months (41% vs 40% vs 39%; p&lt;0.01). After adjustment for age, sex, co-morbidity and deprivation quintile in logistic regression analysis, the rate of gastroscopy (low, medium or high) at the patient9s general practice was an independent predictor of all three outcomes. <h3>Conclusion</h3> There is &gt;10-fold variation in the rate of gastroscopy among general practice populations in England. On average, OGC patients belonging to practices within the lowest tertile have poorer outcomes. These findings suggest that guidelines aimed at reducing the use of gastroscopy may adversely affect cancer outcomes. <h3>Competing interests</h3> None declared.