tbuckley/cabot-search huggingface dataset:
Regression of primary breast tumor and blockage of osteolytic skeletal metastasis by a non-RGD based integrin binding peptide (ATN-161) targeting α5β1 and αvβ3 in a xenograft model of breast cancer
Authors: Parisa Khalili, Marian Plunkett, Ivy Beck, Jason Arimura, Andrew Mazar, Shafaat Rabbani
Journal: Cancer Research (2004)

Proc Amer Assoc Cancer Res, Volume 45, 2004

4001 

Breast cancer is commonly associated with osteolytic skeletal metastasis which results in considerable morbidity and mortality. In the late stages of this malignancy, tumor cells become hormone insensitive and metastasize to several organs including skeleton. ATN-161 is a 5-mer capped peptide that binds to activated α5β1 and ανβ 3 and is currently completing a Phase I trial in patients with advanced solid cancer. In the current study, we have evaluated the ability of ATN-161 to block primary tumor growth and the development of skeletal metastases in a xenograft model of breast cancer. Human breast cancer cells MDA-231 (1 X 105) transfected with green fluorescent protein (MDA-231-GFP) were inoculated into the mammary fat pad of female Balb/c nu/nu mice. After staging of tumors to 50 mm3, animals were infused with vehicle alone or ATN-161 (1 mg/kg 3x/week) i.v. for 6 weeks. Tumor volume of control animals infused with vehicle alone continued to increase over time. In contrast, tumors in experimental animals receiving ATN-161 either regressed or grew significantly more slowly than tumors inbc ontrol animals. In other studies, mice were infused with vehicle alone or ATN-161 for 10 weeks after intracardiac (i.c.) inoculation of tumor cells. Animals were monitored weekly by Faxitron for the development of skeletal metastases. At the end of the study, control and experimental animals were euthanized and and the organs analyzed for the presence of microscopic tumor metastases. While fluorescent metastatic tumor cells were routinely seen in the lungs, liver and spleen of control animals, treatment with ATN-161 resulted in a significant decrease in the number of tumor metastases in these organs. Radiological analysis of long bones demonstrated that ATN-161 treatment completely blocked the development of osteolytic skeletal metastases in the femora and tibia of 3/10 animals and led to a significant decrease in the number and size of osteolytic lesions in 7/10 animals. Bone histomorphometric analysis showed a significant decrease in the total area of osteolysis and tumor/bone ratio in the ATN-161 treated mice. Collectively, these studies demonstrate that ATN-161 can inhibit the progression of primary breast cancer and the development of tumor metastases to soft tissues and skeleton. These studies provide rationale for the development of ATN-161 as an effective therapeutic strategy for patients with late stage breast cancer.
Abstract 202: Automated Heart Rate Complexity Calculation: Reference Ranges in Trauma and Cardiology Patients
Authors: Andriy Batchinsky, Slava Belenkiy, William Baker, Nehemiah Liu, Corina Necsoiu, Kerfoot Walker, Jose Salinas, Leopoldo Cancio
Journal: Circulation (2013)

Objective: Heart rate complexity (HRC), measured by sample entropy (SampEn), and multiscale entropy (MSE), has been useful for detection of injury severity in off-line analysis of animal and human data. However there are no reported reference ranges for these metrics, especially as relevant to automated analysis of the electrocardiogram (ECG) Materials and methods: We developed algorithms for automated R-wave detection and HRC and heart rate variability computation. We used them to analyze a mixed data set of ECGs of various lengths from the US Army Trauma Vitals database (TV, n=71), and the Physionet Holter monitor database (n=30). The TV set was further subdivided into injured patients that received lifesaving interventions (LSI, i.e. intubation, chest tube, transfusion, n=49) or who did not (no LSI, n=22). The Physionet data were separated into these groups: (1) normal sinus rhythm, untreated (n=5); (2) normal sinus rhythm, medicated (n=9); and (3) arrhythmias, medicated (n= 16). Group 3 included patients with intermittent atrial fibrillation or ventricular tachycardia while on anti-arrhythmics. One-way analysis of variance with Tukey’s procedure was performed. Data are means ± SD, unitless unless noted otherwise. Results: see table 1 Conclusions: In agreement with previous off-line manual analysis of ECG, automated HRC analysis showed lower values in more severely injured subjects with LSIs. The reference ranges for HRC and select heart rate variability metrics will be useful for prospective evaluation of patients using automated analysis of the ECG. Table 1.
TOXIC EFFECTS OF AZATHIOPRINE IN RHEUMATOID ARTHRITIS: A National Post‐Marketing Perspective
Authors: Gurkirpal Singh, James F. Fries, Patricia Spitz, Catherine A. Williams
Journal: Arthritis & Rheumatology (1989)

Concerns about the short-term and long-term toxic effects of azathioprine (AZA) have limited its use. Accordingly, we surveyed 393 AZA-treated rheumatoid arthritis (RA) patients, who were recruited and enrolled through a nationwide call to rheumatologists. Findings in these patients were compared with the findings, retrieved from the databank of the American Rheumatism Association Medical Information System, on 153 similarly treated RA patients. All 546 patients were surveyed prospectively, using the Health Assessment Questionnaire and information abstracted from hospital records. The 2 groups were closely similar in clinical characteristics. The most frequently reported side effects of AZA treatment were nausea, vomiting, and leukopenia. Gastrointestinal intolerance accounted for nearly 60% of therapy interruptions in 95 patients. Of 81 hospitalizations for all causes, only 8 may have been related in part to AZA, and no deaths were attributed to AZA therapy. No lymphomas or leukemias were encountered and the overall frequency of neoplasms was not significantly different from that seen in RA patients receiving conventional therapy. As used in the treatment of RA, AZA has a surprisingly benign profile with relatively few serious therapeutic mishaps.
Circulating Endothelial Cells As a Reliable Marker Of Endothelial Damage In Children Undergoing Hematopoietic Stem Cell Transplantation
Authors: Fabien Touzot, Despina Moshous, Guilhem Cros, Pierre Frange, Sebastien Heritier, Benedicte Neven, Marina Cavazzana-Calvo, Alain Fischer, Stephane Blanche, Dominique Helley
Journal: Blood (2013)
Abstract 247: Hands-on Defibrillation Has the Potential to Improve CPR Quality and Is Safe for Rescuers: A Preclinical Study
Authors: Tobias Neumann, Matthias Gruenewald, Christoph Lauenstein, Peter Voelk, Anne Rosenthal, Isabell Hartramph, Tobias Drews, Timo Iden, Patrick Meybohm
Journal: Circulation (2011)

Background: It has been demonstrated that hands-on chest compressions (CC) during cardioversion in humans can be safely performed. [1] We assessed the hypothesis that it will be safe during CPR and improves its quality. Methods: Twenty anesthetized swine were subjected to V-fib and subsequent CPR. Self-adhesive defibrillation electrodes were used with a biphasic defibrillator (corpuls3, G. Stemple GmbH, Germany). Swine were randomized either to i) hands-on defibrillation, where rescuers wore polyethylene gloves and defibrillation was delivered during ongoing CC, or ii) conventional hands-off defibrillation. In the hands-on group CC were interrupted only for rhythm analysis, when a marked increase of arterial blood pressure or endtidal CO 2 was observed suggesting spontaneus circulation. Holter ECG was registered to analyze potential cardiac arrhythmias in rescuers. Results: ROSC was achieved in 9 out of 10 swine in the hands-on group compared to 8 out of 10 (ns). Interruptions in CC were reduced by hands-on technique (p &lt; 0.001) and coronary perfusion pressure (CorPP) was earlier restored to the pre-shock level (p = 0.014). In only 13 of 34 cases (38 %) interruption of hands-on CPR revealed a stable spontaneous circulation. Transthoracic impedance was not significantly different (hands-on 66 ± 40 Ohm vs. hands-off 63 ± 24 Ohm, p = 0.720). During all 37 hands-on shocks rescuers never felt any kind of electric stimulus. Holter ECG analysis did not reveal any serious arrhythmia during hands-on CPR (SVES/h: 5.0 ± 5.4, PVC/h: 0.2 ± 0.5). Conclusions: Hands-on defibrillation shortens CPR pauses and fastens restoration of CorPP that is predictive for CPR outcome. More sophisticated ECG filters may enable rhythm analysis during ongoing CC to avoid unnecessary pauses. Hands-on CPR can be safely performed but clinical studies are needed before implementation into daily practice. References: 1. Lloyd MS et al. Circulation 2008; 117: 2510-4
Abstract 2650: Do Changes In Surface Ekg Predict The Clinical Response To Cardiac Resynchronisation Therapy: Data From The Care-hf Study
Authors: Renaud Gervais, Christophe Leclercq, A Shankar, S Jacobs, Hans Eiskjaer, A Hagemann, Nick Freemantle, John G Cleland, Claude Daubert
Journal: Circulation (2007)
Ischaemic heart disease and cholesterol There's more to heart disease than cholesterol
Authors: L Bonneux, J J Barendregt, U Ravnskov, L E Ramsay, W W Yeo, P R Jackson, T A Sheldon, F Song, J Millo, C L M Sudlow, M R Macleod, J A Heady, J N Morris, M F Oliver, D L Vine, G E Hastings, P N Durrington, A Dugdale, M R Law, T Wu, N J Wald, A Hackshaw, A S G T. Bailey
Journal: BMJ (1994)

Ischaemic heart disease and cholesterolThere's more to heart disease than cholesterol EDrroR,-We are impressed by the "cholesterol papers."1'-3M R Law and colleagues prove that it is
P0465 : Persistent intrahepatic Vγ9Vδ2 T-cells impairment in HCV-infected persons
Authors: E. Cimini, V. Bordoni, U. Visco-Comandini, M. Montalbano, R. Lionetti, A. Sacchi, R. Casetti, N. Tumino, M.R. Capobianchi, F. Martini, C. Agrati
Journal: Journal of Hepatology (2015)
Abstract 3338: Long-Term Outcome of Lung and Heart-Lung Transplantation for Primary Pulmonary Hypertension
Authors: Yoshiya Toyoda, Jnanesh Thacker, Ricardo Santos, Christian Bermudez, Brack Hattler, Dennis McNamara, Michael Mathier, Kenneth McCurry
Journal: Circulation (2006)

Background: The long-term outcome of thoracic transplantation for primary pulmonary hypertension (PPH) is unknown. The purpose of this study was to evaluate the long-term outcome of lung and combin...
State of the art and future directions of pancreatic ductal adenocarcinoma therapy
Authors: Cindy Neuzillet, Annemilaï Tijeras-Raballand, Philippe Bourget, Jérôme Cros, Anne Couvelard, Alain Sauvanet, Marie-Pierre Vullierme, Christophe Tournigand, Pascal Hammel
Journal: Pharmacology & Therapeutics (2015)
Associations between the 17q21 region and allergic rhinitis in five birth cohorts
Authors: Elaine Fuertes, Cilla Söderhäll, Nathalie Acevedo, Allan Becker, Michael Brauer, Moira Chan-Yeung, F. Nicole Dijk, Joachim Heinrich, Gerard Koppelman, Dirkje Postma, Juha Kere, Anita Kozyrskyj, Göran Pershagen, Andrew Sandford, Marie Standl, Carla Tiesler, Melanie Waldenberger, Marit Westman, Christopher Carlsten, Erik Melén
Journal: European Respiratory Journal (2014)

Background:  The 17q21 locus is among the most implicated genetic risk factors for childhood asthma, and may be a shared risk locus with allergic rhinitis. Previous candidate gene studies on the 17q21 locus and allergic rhinitis are small and conflicting.   Objective:  In a pooled analysis of five birth cohorts (BAMSE, GINI/LISA, PIAMA, CAPPS and SAGE; N total =4623), we examined whether seven single nucleotide polymorphisms (SNPs) located at 17q21 were associated with allergic rhinitis, and whether this association was modified in those also diagnosed with asthma.   Methods:  Allergic rhinitis was defined using a questionnaire-based report of doctor diagnosis or symptoms and a concomitant positive test for aeroallergen sensitization at ages four to 16 years (in the pooled data). Generalized estimating equation models, adjusted for age and cohort, assessed longitudinal associations between allergic rhinitis and the SNPs. We then evaluated associations for allergic rhinitis with and without concomitant asthma.   Results:  A significant longitudinal association between allergic rhinitis and rs7216389, previously implicated in genome-wide association studies on asthma, was observed (OR:1.17, 95%CI:[1.06, 1.29] with T as the effect allele). Four other SNPs in high linkage disequilibrium with rs7216389 and a fifth SNP were also associated. Associations appeared greatest for concomitant allergic rhinitis and asthma (1.35 [1.11, 1.63] for rs7216389:T), but were also observed for allergic rhinitis without concomitant asthma (1.12 [1.00, 1.24] for rs7216389:T).   Conclusions:  The results of this large study support the role of the 17q21 locus as a shared genetic susceptibility locus of allergic rhinitis and asthma.
Faster T-cell development following gene therapy compared with haploidentical HSCT in the treatment of SCID-X1
Authors: Fabien Touzot, Despina Moshous, Rita Creidy, Bénédicte Neven, Pierre Frange, Guilhem Cros, Laure Caccavelli, Johanna Blondeau, Alessandra Magnani, Jean-Marc Luby, Brigitte Ternaux, Capucine Picard, Stéphane Blanche, Alain Fischer, Salima Hacein-Bey-Abina, Marina Cavazzana
Journal: Blood (2015)
双手皮损-腹痛-腹泻-发热
Authors: 孟婵, 沙悦, 陈嘉林
Journal: BMJ (2009)

患者女，农民，24岁，主因双手皮损、腹痛、消瘦2个月余于2007年6年13日入院。患者于2007年4月无明显诱因出现双手掌指关节处皮肤变黑，逐渐向远端和近端发展，直至累及全手掌，腕部与正常皮肤间界限清晰。皮损以手背为重，局部皮肤肿胀、变硬、破溃流脓，双手指活动受限，但无疼痛或瘙痒感。同时出现阵发脐周绞痛，
Abstract 16196: The Economic Value of Statin Therapy
Authors: Tomas Philipson, Darius N Lakdawalla, Dana Goldman, Michael Eber, Tamer Abdelgawad, Andreas Kuznik, Larry Z Liu, Michael Chernew, David C Grabowski
Journal: Circulation (2011)

Introduction: Medical innovation has frequently produced improvements in the length and quality of life, but at greater initial cost. It is natural to ask whether and to what extent the ultimate so...
Modifiers of C9orf72 dipeptide repeat toxicity connect nucleocytoplasmic transport defects to FTD/ALS
Authors: Ana Jovičić, Jerome Mertens, Steven Boeynaems, Elke Bogaert, Noori Chai, Shizuka B Yamada, Joseph W Paul, Shuying Sun, Joseph R Herdy, Gregor Bieri, Nicholas J Kramer, Fred H Gage, Ludo Van Den Bosch, Wim Robberecht, Aaron D Gitler
Journal: Nature Neuroscience (2015)
Histopathologic and Cytogenetic Features of Pulmonary Adenoid Cystic Carcinoma
Authors: Anja C. Roden, Patricia T. Greipp, Darlene L. Knutson, Sara M. Kloft-Nelson, Sarah M. Jenkins, Randolph S. Marks, Marie Christine Aubry, Joaquín J. García
Journal: Journal of Thoracic Oncology (2015)
Abstract 15370: The Development of LO1, a Novel IgG Monoclonal Natural Antibody, for the Near Infra-Red (NIRF) Imaging of Oxidised LDL in Atherosclerosis
Authors: Ramzi Khamis, Shang-Hung Chang, Joseph Boyle, Colin Bicknell, Michael Johns, Dorian O Haksard
Journal: Circulation (2012)

Background: The identification of inflammatory activity may help to better understand the relationship between vulnerable plaque and clinical syndromes, as well to allow for future therapeutic targ...
Abstract 4136: Incidence and Progression of Coronary Calcium Associated with Metabolic Syndrome and Diabetes in the Multiethnic Study of Atherosclerosis
Authors: Nathan D Wong, Roger Blumenthal, Jeffrey Carr, Alan Guerci, Richard Kronmal, Alain Bertoni, Russell Tracy, Mohammed Saad, David Jacobs, Kiang Liu, Robert Detrano
Journal: Circulation (2006)
Abstract 760: Alterations in Fibroblast Phenotype during Murine Thoracic Aortic Aneurysm Development
Authors: Jeffrey A Jones, Juozas A Zavadzkas, Eileen I Chang, Christine N Koval, Robert E Stroud, John S Ikonomidis
Journal: Circulation (2008)

Thoracic aortic aneurysms (TAAs) result from maladaptive remodeling of the vascular extracellular matrix (ECM). In addition to structural protein changes, resident cellular profiles are altered leaving the fibroblast as the predominant cell type within the vascular wall. The present study tests the hypothesis that fibroblast phenotype is also altered during TAA development. Primary murine aortic fibroblasts were isolated from normal (n=4) and TAA aortas (n=3; 4-wks post-induction; topical 0.5M CaCl 2 15 min) by the outgrowth method. Cultures were established and passages 3–5 were used for gene expression profiling in the absence of stimulation. Relative expression of 30 genes (MMPs, ECM proteins, transcription factors) normalized to 4 house keeping genes was measured by quantitative real-time PCR. Genes displaying a minimum 2-fold increase/decrease or genes with significantly different normalized Ct values (t-test, TAA vs. control; p&lt;0.05) were considered to have altered expression Steady state gene expression of 4-wk TAA versus normal fibroblasts revealed elevated expression of Mmp2, Mmp11, Mmp15, Col1a1, Col1a2, Col3a1, Eln, Lamb2, Fn1, Fbn2, Spp1, Sparc, Fos, and Fosb, and decreased expression of Mmp3, Timp3, Ltbp1, Sp1, and Junb ( Figure ). This study demonstrates for the first time that isolated aortic fibroblasts from 4-wk TAAs possess a unique gene expression profile as compared to normal fibroblasts. This suggests they have undergone a stable phenotypic change, which may be the result of a clonal expansion of a subset of cells, and may play a significant role in TAA development through the enhancement of ECM proteolysis.
Brain drain and health professionals
Authors: D. I Stein
Journal: BMJ (2002)

# Is state ownership of health professionals' intellect being proposed? {#article-title-2} EDITOR—In their editorial on the migration of medical professionals Pang et al suggest that "Just as intellectual property rights need to be discussed by developed and developing countries together, so also should the preservation of the intellectual property of a nation, embodied in its health professionals, be addressed by international organisations."1 Does this mean that the state or some international organisation has a financial claim on a person's intellect? It is one thing to require public service in exchange for education as long as both parties agree beforehand. It is quite another to extort service or money from people who have paid for their own education; this type of action would be justified only at a time of national calamity, such as a world war. Because we so value liberty, most Americans would find this view utterly preposterous. Hopefully many British people will as well. 1. ↵1. Pang T, 2. Lansang MA, 3. Haines A .Brain drain and health professionals.BMJ2002; 324:499–500. (2 March.) [OpenUrl][1][FREE Full Text][2] # Brain drain disseminates skill and advances science {#article-title-4} EDITOR—I cannot understand why some people have difficulty understanding the freedom of movement of professionals.1Professionals move from one region to another and from one country to another all the time. It happens everywhere. This phenomenon is nothing new. The people who leave their country have their reasons for going. Einstein left Germany for the United States in the 1930s for fear of Nazi persecution. Osler emgrated from Canada to John Hopkins University in the United States and eventually ended up in Oxford, England. In the United States we have a variety of professionals from all over the earth. This phenomenon enriches cultures, disseminates skill and information, and advances science and technology. I … [1]: {openurl}?query=rft.jtitle%253DBMJ%26rft.stitle%253DBMJ%26rft.issn%253D0007-1447%26rft.aulast%253DPang%26rft.auinit1%253DT.%26rft.volume%253D324%26rft.issue%253D7336%26rft.spage%253D499%26rft.epage%253D500%26rft.atitle%253DBrain%2Bdrain%2Band%2Bhealth%2Bprofessionals%26rft_id%253Dinfo%253Adoi%252F10.1136%252Fbmj.324.7336.499%26rft_id%253Dinfo%253Apmid%252F11872536%26rft.genre%253Darticle%26rft_val_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Ajournal%26ctx_ver%253DZ39.88-2004%26url_ver%253DZ39.88-2004%26url_ctx_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Actx [2]: /lookup/ijlink?linkType=FULL&journalCode=bmj&resid=324/7336/499&atom=%2Fbmj%2F325%2F7357%2F219.atom
Abstract 9981: Systolic Heart Failure is Associated with Decreased Mitochondrial Respiration in Biopsies From Human Left Ventricle
Authors: Nis Stride, Steen Larsen, Martin Hey-Mogensen, Christina N Hansen, Lars Køber, Daniel Steinbrüchel, Flemming Dela
Journal: Circulation (2011)

Heart failure (HF) with left ventricular systolic dysfunction (LVSD) is associated with a shift in substrate utilization (metabolic remodeling) and reduced ATP and phosphocreatine (PCr) content. We hypothesized that these changes could be caused by reduced mitochondrial oxidative phosphorylation (OXPHOS) and reduced mitochondrial creatine kinase (miCK) capacity. Myocardial biopsies were obtained from left ventricle of patients undergoing cardiac valve- and left ventricular assist device (LVAD), surgery. The patients were stratified in two groups according to left ventricular ejection fraction (LVEF): Controls (LVEF= 55±2%, n=14) and LVSD (LVEF= 17±3%, n=12). Mitochondrial respiration was measured in permeabilized muscle fibers during successive additions of Krebs cycle substrates. In a separate experiment we assessed the oxidation of octanoyl-L-carnitine, a medium chain fatty-acid (MCFA). The kinetics of miCK was determined from APD titrations in the presence or absence of creatine, revealing the in situ enzyme capacity (Vmax) and sensitivity (C50). Octanoyl-L-carnitine elicited 41 % lower respiration in LVSD than in controls (10±2 vs. 17±2 ρmol sec -1 mg -1 , respectively, figure 1, P &lt;0.05), whereas the sensitivity (C50) for octanoyl-L-carnitine was the same in both groups. Maximal respiratory capacity with dual electron input through complex I and II (malate, glutamate, succinate) was lower in the LVSD group compared with controls (76±8 vs. 104 ±7 pmol sec -1 mg -1 , respectively, P &lt;0.05). Addition of creatine increased ADP sensitivity significantly in both groups (62 % vs 42 % reduction C50 respectively, P &lt;0.05), but revealed no significant differences in Vmax. The novel finding of this study is that human LVSD is associated with a markedly diminished OXPHOS capacity, particularly in the oxidation of MCFA. This offers a candidate mechanism for decreased reliance on fatty-acid utilization in HF and for decreased myocardial ATP and PCr content.
Abstract 474: Metabolic Syndrome contributes to Aspirin-Resistant Thromboxane Biosynthesis via Inducing Platelets COX-2 Expression in Patients with Stable Angina
Authors: Kagari M Murasaki, Hisako Omori, Kayoko Sato, Nobihisa Hagiwara, Hiroshi Kasanuki
Journal: Circulation (2006)

Background A large number of patients still experience a vascular event despite aspirin treatment. Cyclooxygenase-1 (COX-1), but not COX-2, is expressed in human platelets, and thromboxane A2 (TXA2...
Log Reduction Levels of WT1 mRNA Expression in BM after Chemotherapies Are Predictive Markers of Good Prognosis in AML Patients Achieved CR after Induction Therapy
Authors: Yasuhiko Shibasaki, Yoshinobu Seki, Tomoyuki Tanaka, Syukuko Miyakoshi, Kyoko Fuse, Takashi Kozakai, Hironori Kobayashi, Takashi Ushiki, Takashi Abe, Toshio Yano, Masato Moriyama, Takashi Kuroha, Noriatsu Isahai, Jun Takizawa, Miwako Narita, Satoru Koyama, Tatsuo Furukawa, Hirohito Sone, Masayoshi Masuko
Journal: Blood (2014)
Abstract 12010: Physiological Overexpression of PGC-1alpha Preserves Mitochondrial Function and Reduces Fibrosis but Does Not Prevent Cardiac Dysfunction Following Pressure Overload Hypertrophy
Authors: Renata O Pereira, Ashley Crum, Adam R Wende, Curtis D Olsen, E. Dale Abel
Journal: Circulation (2011)

Peroxisome proliferator-activated receptor coactivator-1 alpha (PGC-1α) is an inducible integrator of transcriptional circuits that regulate mitochondrial biogenesis and function. In physiological ...
Platelet/Polymorphonuclear Leukocyte Interaction: P-Selectin Triggers Protein-Tyrosine Phosphorylation–Dependent CD11b/CD18 Adhesion: Role of PSGL-1 as a Signaling Molecule
Authors: Virgilio Evangelista, Stefano Manarini, Rita Sideri, Serenella Rotondo, Nicola Martelli, Antonio Piccoli, Licia Totani, Paola Piccardoni, Dietmar Vestweber, Giovanni de Gaetano, Chiara Cerletti
Journal: Blood (1999)