THERAPEUTIC POSSIBILITIES OF PARA-AMINOBENZOIC ACID
Authors: C J D ZARAFONETIS
Journal: Annals of Internal Medicine (1949)

Article1 June 1949THERAPEUTIC POSSIBILITIES OF PARA-AMINOBENZOIC ACIDCHRIS J. D. ZARAFONETIS, M.D.CHRIS J. D. ZARAFONETIS, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-30-6-1188 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptPara-aminobenzoic acid (PABA) is generally considered to be a member of the B-complex group of vitamins, and is known to be a constituent of many food substances.1, 2Although it is a chemical which has long been known, this substance has been of medical interest only during the past decade. From the available literature, however, the principal interest has been largely confined to studies of its effects on bacterial metabolism, pigment metabolism, and other fields of laboratory investigation. The first important clinical use of PABA was evolved during World War II, when it was found to be of value in...Bibliography1. ROSENBERG HR: Chemistry and physiology of the vitamins, 1945, Interscience Publishers, New York. Google Scholar2. BICKNELLPRESCOTT FF: The vitamins in medicine, 1946, Grune and Stratton, New York. Google Scholar3. SNYDER JC: Treatment of the rickettsial diseases of man, a symposium on the Rickettsial Diseases of Man, 1948, American Association for Advancement of Science, Washington. Google Scholar4. ZARAFONETISCURTISKIRKMAN CJACLW: Para-aminobenzoic acid in lymphoblastoma cutis and mycosis fungoides. To be published. Google Scholar5. ZARAFONETIS CJ: Para-aminobenzoic acid therapy in scleroderma and lymphoblastoma cutis, abstr., Jr. Lab. and Clin. Med., 1948, xxxiii, 1462. Google Scholar6. ZARAFONETISCURTISGREKIN CJACRH: The effects of para-aminobenzoic acid in lupus erythematosus, Univ. Hosp. Bull., 1947, xiii, 122-125. Google Scholar7. 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Y., March 30, 1949.From the Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan.†The solutions of NaPAB and KPAB administered to the cases reported herein were prepared from crystalline para-aminobenzoic acid which was generously contributed by Merck and Co., Rahway, New Jersey.‡Tablets of "PABA Sodium" were kindly supplied for use in these patients by Wyeth and Co., Philadelphia, Pennsylvania. 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