Hepatotoxicity of Combination Chemotherapy for Acute Myelocytic Leukemia
Authors: JOHN S. PENTA
Journal: Annals of Internal Medicine (1977)

Letters and Corrections1 August 1977Hepatotoxicity of Combination Chemotherapy for Acute Myelocytic LeukemiaJOHN S. PENTA, PH.D., DANIEL D. VON HOFF, M.D., FRANCO M. MUGGIA, M.D.JOHN S. PENTA, PH.D.Search for more papers by this author, DANIEL D. VON HOFF, M.D.Search for more papers by this author, FRANCO M. MUGGIA, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-87-2-247_2 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: Recently, reports have appeared that describe hepatotoxicity in patients with acute leukemia after combination chemotherapy with antimetabolites and anthracycline antibiotics (1, 2). Over the past 9 months since Dr. J. Lawrence Naiman (St. Christopher's Hospital for Children, Philadelphia, Pennsylvania) first brought to our attention four cases of possible hepatotoxicity after daunorubicin therapy, we have received a total of 13 reports on leukemia patients with hepatotoxicity after administration of 6-thioguanine or cytarabine (cytosine arabinoside), or both, in combination with the anthracycline antibiotic daunorubicin (see Table 1).Most of the patients were in remission at the onset of hepatic...References1. GRINER P, ELBADAWI A, and PACKMAN C: Veno-occlusive disease of the liver after chemotherapy of acute leukemia. Ann Intern Med 85:578-582, 1976 LinkGoogle Scholar2. MINOW R, STERN M, and CASEY J: Clinico-pathologic correlation of liver damage in patients treated with 6-mercaptopurine and adriamycin. Cancer 38:1524-1528, 1976 CrossrefMedlineGoogle Scholar3. PITTILLO R and WOOLLEY C: Disposition of arabinosyl cytosine (NSC 63878) and 6-thioguanine (NSC 762) in solid L1210 leukemia tumor-bearing mice. Cancer Chemother Rep 57 (Part 1):275-289, 1973 MedlineGoogle Scholar4. PANNUTI F, LEGABUE A, and TRASARTI F: Pharmacologic interaction in oncology: modification of pharmacokinetics of 6-mercaptopurine (6-MP) in animals pretreated with adriamycin (Adria). Riv Patol Clin 29:169-174, 1974 Google Scholar5. RODRIGUEZ V, BODEY G, and MCCREDIE K: Combination 6-mercaptopurine-adriamycin in refractory adult acute leukemia. Clin Pharmacol Ther 18:462-466, 1975 CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: JOHN S. PENTA, PH.D.; DANIEL D. VON HOFF, M.D.; FRANCO M. MUGGIA, M.D.Affiliations: National Cancer Institute Bethesda, MD 20014 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byBrain Perfusion in Adult Patients with Acute Myeloblastic Leukemia before and after Cytosine ArabinosideDrug-Induced Liver DiseaseSinusoidal Obstruction SyndromeDRUG-INDUCED HEPATIC VASCULAR ABNORMALITIESPediatric Hepatic Drug ReactionsProphylactic heparin does not prevent liver veno-occlusive disease following autologous bone marrow transplantationAcral erythema and systemic toxicity related to CHA induction therapy in acute myeloid leukemiaA COMPARATIVE PATHOLOGICAL STUDY OF LIVER INJURY AFTER DIFFERENT COMBINATION CHEMOTHERAPIES FOR LEUKEMIADifferent cytotoxicity and metabolism of doxorubicin, daunorubicin, epirubicin, esorubicin and idarubicin in cultured human and rat hepatocytesPeliosis hepatis induced by 6-thioguanine administration.Peripheral neuropathy associated with high-dose ara-C therapyVeno-occlusive disease of the liver in children following chemotherapy for acute myelocytic leukemiaDrug effects on the liverHepatic and pancreatic damage produced by cytotoxic drugs6-Thioguanine as a cause of toxic veno-occlusive disease of the liverCentral nervous system toxicity of high-dose systemic cytosine arabinosideAn analysis of hepatic venocclusive disease and centrilobular hepatic degeneration following bone marrow transplantationLong-Term Sequelae of Cancer ChemotherapyAntineoplastic agents and the liverMEASUREMENT OF LACTOFERRIN IN PANCREATIC JUICEGENERAL ANÆSTHESIA FOR HIGH-DOSE TOTAL-BODY IRRADIATIONClinical correlations of adriamycin pharmacology 1 August 1977Volume 87, Issue 2 Page: 247-248 Keywords Acute myeloid leukemia Antibiotics Children Combination chemotherapy Cytosine ePublished: 1 December 2008 Issue Published: 1 August 1977 PDF downloadLoading ...