Successful Treatment of Hepatitis C in Sickle-Cell Disease
Authors: Mark W. Swaim
Journal: Annals of Internal Medicine (2000)

Letters7 November 2000Successful Treatment of Hepatitis C in Sickle-Cell DiseaseMark W. Swaim, MD, PhD, Swati Agarwal, MD, and Wendell F. Rosse, MDMark W. Swaim, MD, PhDDuke University Medical Center; Durham, NC 27710 (Swaim, Agarwal, Rosse)Search for more papers by this author, Swati Agarwal, MDDuke University Medical Center; Durham, NC 27710 (Swaim, Agarwal, Rosse)Search for more papers by this author, and Wendell F. Rosse, MDDuke University Medical Center; Durham, NC 27710 (Swaim, Agarwal, Rosse)Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-133-9-200011070-00033 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:Patients with sickle-cell disease are at high risk for hepatitis C virus (HCV) infection; HCV seropositivity rates in this group are as high as 30% (1). In the U.S. population, 1.8% of patients with this disease are infected with HCV (2). Cirrhosis caused by HCV may supervene as an important cause of death as patients with sickle-cell disease live longer. Indeed, liver transplantation for HCV-related cirrhosis has been performed in patients with sickle-cell disease (3). Although patients with sickle-cell disease commonly survive to their sixth decade (4, 5), treatment of HCV infection in these patients has not ...References1. DeVault KR, Friedman LS, Westerberg S, Martin P, Hosein B, Ballas SK. Hepatitis C in sickle cell anemia. J Clin Gastroenterol. 1994;18:206-9. CrossrefMedlineGoogle Scholar2. Alter MJ. Epidemiology of hepatitis C. Hepatology. 1997;26 3 Suppl 1 62S-65S. CrossrefMedlineGoogle Scholar3. Kindscher JD, Laurin J, Delcore R, Forster J. Liver transplantation in a patient with sickle cell anemia. Transplantation. 1995;60:762-4. CrossrefMedlineGoogle Scholar4. Platt OS, Brambilla DJ, Rosse WF, Milner PF, Castro O, Steinberg MH, et al . Mortality in sickle cell disease. Life expectancy and risk factors for early death. N Engl J Med. 1994;330:1639-44. CrossrefMedlineGoogle Scholar5. Charache S, Terrin ML, Moore RD, Dover GJ, Barton FB, Eckert SV, et al . Effect of hydroxyurea on the frequency of painful crises in sickle cell anemia. Investigators of the Multicenter Study of Hydroxyurea in Sickle Cell Anemia. N Engl J Med. 1995;332:1317-22. CrossrefMedlineGoogle Scholar Author, Article, and Disclosure InformationAuthors: Mark W. Swaim, MD, PhD; Swati Agarwal, MD; Wendell F. Rosse, MDAffiliations: Duke University Medical Center; Durham, NC 27710 (Swaim, Agarwal, Rosse) PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byHepatitis C Infection in Patients With HemoglobinopathiesSickle Cell DiseaseHepatobiliary Complications of Sickle Cell AnemiaTreating hepatitis C in patients with hemoglobinopathiesPeg-interfon alpha-2a and low-dose ribavirin for treatment of hepatitis C virus infection in patients with sickle-cell anemia in Saudi ArabiaTransplantation for liver failure in patients with sickle cell disease: Challenging but feasibleSafety of pegylated interferon and ribavirin therapy for chronic hepatitis C in patients with sickle cell anemiaTreatment of chronic hepatitis C in sickle cell disease and thalassaemic patients with interferon and ribavirinHepatitis C Virus Infection 7 November 2000Volume 133, Issue 9 Page: 750-751 Keywords Cirrhosis Hematocrit Hemoglobin Infectious diseases Liver fibrosis Liver transplantation Lymphocytes Patients Platelets RNA ePublished: 7 November 2000 Issue Published: 7 November 2000 Copyright & PermissionsCopyright © 2000 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...