tbuckley/cabot-search huggingface dataset:
Hormonal stress in adolescent female volleyball players
Authors: J C Cruz-Márquez, J C Cruz-Campos, A Cruz-Campos, MªB Cueto-Martín, Mª García-Jiménez
Journal: British Journal of Sports Medicine (2011)

Background Catecholamine and cortisol are markers of hormonal stress in young female athletes and may indicate adaptation to an active lifestyle and sports activity. Objective To discover if volleyball training produces changes in catecholamine and cortisol. Design We performed a prospective study during a sports season (September–May) with monthly measurements of catecholamine and cortisol in urine collected over a 24-h period, on a rest day and between days 5 and 25 of the menstrual cycle. Setting and participants 24 women (mean age 17±0.5 years; height: 172.8±4.7 cm; weight: 60.7±3.8 kg), volleyball players from two youth teams competing regionally (years of training: 3±0.4) and 24 sedentary women (ages: 17±0.9; height: 161±5.8 cm; weight: 58±5.6) selected from the high school. Participating teams: Ranked first and second last season. All players who started the study completed it. None of the participants were taking contraceptives or receiving hormonal treatments. Interventions The players trained four days/week (an average of 8.3 h/week) and played 24 official matches. The sedentary women attended a physical education class 2 days/week (2 h/week), along with the players. Independent Variables: exercise, volleyball training and healthy lifestyle. Dependent Variables: urinary catecholamines and cortisol. Results The sedentary participants had higher levels of epinephrine, norepinephrine, dopamine, metanephrine, normetanephrine and cortisol than the women athletes (p&lt;0.05). Higher levels of catecholamines were recorded in September and October in both groups, whereas cortisol levels were higher in April and May. All levels were in normal ranges. There were no significant differences between players based on minutes of competition. Conclusions Playing volleyball and following a healthy lifestyle do not increase levels of catecholamines and cortisol in well-trained adolescent girls.
Visualization of Distal Splenorenal Shunt by Isotopic Splenovenography
Authors: Minoru Sukigara, Toshiro Komazaki, Kazumi Koga, Tatsuya Miyamae, Ryozo Omoto
Journal: Clinical Nuclear Medicine (1987)

Radioisotopic angiography of the splenic vein was performed in six patients following a distal splenorenal shunt (Warren procedure). Under echographic guidance, the spleen was punctured with a 22-gauge needle, and Tc-99m pertechnetate was injected into the splenic pulp. In five patients whose esophageal varices had remained atrophic, the splenic vein, the left renal vein, the inferior vena cava, and the heart were clearly visualized within 8 seconds. In one patient, in whom recurrence of esophageal varices had been recognized, the splenic vein was not imaged. The injected material coursed mainly upwards through collaterals.
Endothelium bound extracellular superoxide dismutase type C reduces damage in reperfused ischaemic rat hearts
Authors: P.-O. Sjoquist, S. L Marklund
Journal: Cardiovascular Research (1992)

Objective: The aim was to determine if endothelium associated extracellular superoxide dismutase type C (EC-SOD C) exerts any protective effect against cardiac damage induced by ischaemia and reperfusion. Methods: Langendorff perfused rat hearts were subjected to 15 min global ischaemia followed by reperfusion. Prior to the ischaemia the hearts were perfused for 15 min with a buffer containing recombinant human EC-SOD C (rh-EC-SOD C, 20 mg·litre−1), or the corresponding vehicle, followed by extensive perfusion with SOD free medium. Results: In hearts receiving the vehicle, reperfusion was associated with a marked release of creatine kinase into the effluent [28 (SEM 1.5) IU·15 min−1, n=5] and coronary flow measured 15 min after initiation of reperfusion was reduced by 68% compared to preischaemic flow. In hearts pretreated with EC-SOD C but washed with enzyme free buffer before being subjected to ischaemia, the creatine kinase release was significantly smaller, at 14(2.1) IUmin−1, n=5 (p<0.001), and the reduction in coronary flow less extensive (54%, p<0.05, v vehicle). To demonstrate the binding of EC-SOD C to the endothelium, heparin, which releases EC-SOD C from the endothelial surfaces, was added to the perfusate 30 min after initiation of reperfusion. The same amount of EC-SOD C was released to the effluent from previously ischaemic hearts [(12.4(2) μg)] as from hearts not subjected to ischaemia [(13.8(1.4) μg)]. Conclusions: Recombinant human EC-SOD type C bound to the endothelial surface reduces the cardiac damage associated with ischaemia and reperfusion. The protective effect was evident both in terms of a reduction of biochemical markers of injury and a better preservation of postischaemic coronary flow. Furthermore, ischaemia and subsequent reperfusion did not cause any alteration in the binding capacity of EC-SOD C to the cardiac vasculature.
Vitamin E for Chronic Hepatitis B
Authors: Pietro Andreone
Journal: Annals of Internal Medicine (1998)

Letters15 January 1998Vitamin E for Chronic Hepatitis BPietro Andreone, MD, Annagiulia Gramonzi, and Mauro BernardiPietro Andreone, MDUniversita di Bologna; 40138 Bologna, ItalySearch for more papers by this author, Annagiulia GramonziUniversita di Bologna; 40138 Bologna, ItalySearch for more papers by this author, and Mauro BernardiUniversita di Bologna; 40138 Bologna, ItalySearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-128-2-199801150-00019 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:Interferon-α for chronic hepatitis B is often ineffective and is associated with drawbacks, such as prolonged parenteral schedules, high costs, and side effects [1]. Oral vitamin E is an inexpensive antioxidant that can stimulate the immune response and does not induce side effects [2]. We evaluated vitamin E supplementation as therapy for chronic hepatitis B.Twenty-four patients (12 were positive for hepatitis B e antigen [HBeAg] and 12 were infected by the “e” minus mutant) with elevated serum alanine aminotransferase (ALT) levels and serum hepatitis B virus DNA (Abbott Laboratories, North Chicago, Illinois) were randomly assigned to ...References1. Lok AS. Treatment of chronic hepatitis. Br J Virol Hepatol. 1994; 1:105-24. Google Scholar2. Meydani M. Vitamin E. Lancet. 1995; 345:170-5. Google Scholar Author, Article, and Disclosure InformationAuthors: Pietro Andreone, MD; Annagiulia Gramonzi; Mauro BernardiAffiliations: Universita di Bologna; 40138 Bologna, Italy PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byAntioxidant supplements for liver diseasesEfficacy of vitamin E in children with immunotolerant-phase chronic hepatitis B infectionVitamin E in Chronic Liver Diseases and Liver FibrosisHigh-dose vitamin E supplementation does not diminish ribavirin-associated haemolysis in hepatitis C treatment with combination standard α-interferon and ribavirinImpaired response to 5mU/day interferon treatment in African-Americans with chronic hepatitis CVitamin E as treatment for chronic hepatitis B: results of a randomized controlled pilot trialInterferon/antioxidant combination therapy for chronic hepatitis C—a controlled pilot trial 15 January 1998Volume 128, Issue 2Page: 156-157KeywordsAlanine aminotransferaseChronic hepatitis BClinical laboratoriesDNAHepatitis BHepatitis B virusImmune responseImmune systemInfectious hepatitisVitamin E ePublished: 15 August 2000 Issue Published: 15 January 1998 Copyright & PermissionsCopyright © 1998 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
17. Visualization of the Intranuclear rAAV Replication Centers and Their Co-Localization with Double-Stranded DNA Break Repair Proteins
Authors: Cervelli Tiziana, Lorena Zentilin, Alessandro Marcello, Mauro Giacca
Journal: Molecular Therapy (2005)

We have developed a method for the visualization of the sites of conversion of the ssDNA AAV genome to dsDNA inside the cell nucleus. This method is based on the utilization of a recombinant AAVlacO.14 vector, containing 112 LacR binding sites (lacO) cloned between the viral ITRs, which is used for the infection of cells that constitutively express a LacR-GFP fusion protein. The rationale of this approach is that the fluorescent sequence-specific DNA binding protein only binds its target site when this is present in a dsDNA form; this permits visualization and monitoring of ss to ds AAV genome conversion over time.
1,230 Cases of Acute Bronchiolitis in Infancy
Authors: T. C. Noble
Journal: BMJ (1962)

From the Slunderland Children's Hospital Six years ago we described a single epidemic of acute bronchiolitis involving 164 infants (Heycock and Noble, 1956).Since then 1,230 cases of this disease have been treated in Sunderland Children's Hospital, and we think it is of interest to analyse their case records and to consider theories of aetiology and treatment on the basis of this experience.We define acute bronchiolitis as a potentially serious infective illness of infancy which involves the whole respiratory tract and in which bronchospasm plays a large part. Clinical DescriptionThe baby acquires a cold from an older child or adult.usually in the family.The baby itself develops a nasal discharge and slight cough with anorexia.This clinical picture may remain unchanged for a few days before clearing up or there may be a rapid increase in the severity of the symptoms.In the more severely affected patients acute respiratory distress, including frequent irritating unproductive cough and bronchospasm, can
Stress Fracture of the Ulnar Styloid Protuberance
Authors: Panagiotis Georgoulias, Nikolaos Demakopoulos, Ioannis Fezoulidis
Journal: Clinical Nuclear Medicine (2005)

Stress fractures of the upper extremities are uncommon but can be a serious source of morbidity if not correctly diagnosed. We present a rare case of a 49-year-old female typist, who reported a 4-month history of a pain located in the region of the left lower ulnar epiphysis and extended to the left portion of the wrist. The patient did not mention any injury. The pain was exacerbated during typing and the clinical diagnosis of tendonitis was made initially. Because of the patient's persistent symptoms, she underwent a plain radiograph investigation in the region of the left lower forearm and wrist, which did not reveal any bone lesion. Consequently, we performed a 3-phase bone scan that showed findings consistent with a fracture of the left ulnar styloid protuberance. The fracture was thought to have a stress origin attributed to the patient's tough working.
SETBP1 mutations occur in 9% of MDS/MPN and in 4% of MPN cases and are strongly associated with atypical CML, monosomy 7, isochromosome i(17)(q10), ASXL1 and CBL mutations
Authors: M Meggendorfer, U Bacher, T Alpermann, C Haferlach, W Kern, C Gambacorti-Passerini, T Haferlach, S Schnittger
Journal: Leukemia (2013)
Interferon γ Enhances Both In Vitro and In Vivo Priming of CD4+ T Cells for IL-4 Production
Authors: Petr Bocek, Gilles Foucras, William E. Paul
Journal: The Journal of Experimental Medicine (2004)

Classical studies have demonstrated that in vitro priming of naive CD4 T cells to become T helper (Th)2 cells is strikingly dependent on interleukin (IL)-4, whereas priming for interferon (IFN)gamma production is IL-12/IFNgamma-dependent. Therefore, it was quite surprising when we noted that priming of naive C57BL/6 CD4(+) cells to become IL-4 producers was substantially inhibited by the addition of anti-IFNgamma antibodies. This was true using immobilized anti-CD3 and anti-CD28 antibodies or soluble anti-CD3/anti-CD28 and antigen-presenting cells in the presence or absence of added IL-4. Priming of CD4 T cells from IFNgamma(-/-) C57BL/6 mice with immobilized anti-CD3 and anti-CD28 resulted in limited production of IL-4, even with the addition of 1,000 U/ml of IL-4. Titrating IFNgamma into such cultures showed a striking increase in the proportion of T cells that secreted IL-4 upon challenge; this effect was completely IL-4-dependent in that it was blocked with anti-IL-4 antibody. Thus, IFNgamma plays an unanticipated but substantial role in Th2 priming, although it is an important Th1 cytokine, and under certain circumstances a Th1 inducer.
Dope Fiend to Drug Addict
Authors: William W. Stead
Journal: JAMA (1972)

<h3>To the Editor.—</h3> I have just read your EDITORIAL entitled, "From Dope Fiend to Drug Addict" in which you mentioned Dr. Lewis Thomas's suggestion for an approach to the problem through a vast enlargement of methadone programs. This prompts me to call to your attention an article in<i>Science</i>for 26 May, 1972, entitled "The Methadone Illusion," in which Lennard, Epstein, and Rosenthal point out that "the heroin problem" is not a problem but merely a small part of a larger problem of society today.<sup>1</sup>They emphasize that substituting one drug for another is not a solution but merely a means of enabling the rest of us to feel that we are doing something. Actually, a person who is taking methadone is still an addict who is taking a potent drug and whose life and outlook are profoundly affected by a potent drug, even though it is given under
De Sapientia Veterum (The wisdom of the ancients)
Authors: R. Maskell
Journal: BMJ (2002)

On my first firm as a student at “Barts” in the early 1950s I was taught so much more than surgery by two eminent surgeons of the day. One small and seemingly insignificant piece of advice was that painful cracks around the mouth should be treated with Ung Hydrarg Ammon Dil .

I never forgot this cumbersome name and when, some years later, my family was bothered by such cracks, either beside the mouth or at the tips of the fingers, we had no problem in obtaining the ointment from the local chemist. A minute …
Book: Suicide: An Unnecessary Death
Authors: R. Persaud
Journal: BMJ (2001)

Ed Danuta Wasserman Martin Dunitz, £29.95, pp 286 ISBN 1 85317 822 5 Rating: ![Graphic][1]</img>![Graphic][2]</img>![Graphic][3]</img> Around the world, approximately one million people a year take their own lives, but of greatest concern is the recent rise in suicide rates among young people. The largest proportion of suicides now committed relates to those below the age of 45. This “ungreying” of suicide, traditionally associated with later life, acquires a dramatic aspect when one considers that the proportion of elderly people in the total population … [1]: /embed/inline-graphic-1.gif [2]: /embed/inline-graphic-2.gif [3]: /embed/inline-graphic-3.gif
Acute voltage, charge, and energy thresholds as functions of electrode size for electrical stimulation of the canine heart
Authors: F. W. LINDEMANS, A. N. E. ZIMMERMAN
Journal: Cardiovascular Research (1979)

Journal Article Acute voltage, charge, and energy thresholds as functions of electrode size for electrical stimulation of the canine heart Get access FRED W. LINDEMANS, FRED W. LINDEMANS 1 From the Departments of Medical Physics and Cardiology, University of Utrecht and University Hospital Utrecht, The Netherlands 1Correspondence and reprint requests to: Fred W. Lindemans, Medtronic, Inc., 3055 Old Highway Eight, Minneapolis, MN 55440, USA. Search for other works by this author on: Oxford Academic PubMed Google Scholar ARIAEN N. E. ZIMMERMAN ARIAEN N. E. ZIMMERMAN From the Departments of Medical Physics and Cardiology, University of Utrecht and University Hospital Utrecht, The Netherlands Search for other works by this author on: Oxford Academic PubMed Google Scholar Cardiovascular Research, Volume 13, Issue 7, July 1979, Pages 383–391, https://doi.org/10.1093/cvr/13.7.383 Published: 01 July 1979
Workplace exposure to passive smoking and risk of cardiovascular disease: summary of epidemiologic studies.
Authors: I Kawachi, G A Colditz
Journal: Environmental Health Perspectives (1999)

We reviewed the published epidemiologic studies addressing the relationship between workplace exposure to environmental tobacco smoke (ETS) and cardiovascular disease risk in three case-control studies and three cohort studies. Although the point estimates of risk for cardiovascular disease exceeded 1.0 in five of six studies, none of the relative risks was statistically significant because of the small number of cardiovascular end points occurring in individual studies. In common with most epidemiologic investigations of the health risks of ETS, none of the workplace studies included independent biochemical validation of ETS exposure. In contrast to the evidence on increased cardiovascular disease risk from exposure to spousal ETS, studies of ETS exposure in the workplace are still sparse and inconclusive. Conversely, there is no biologically plausible reason to believe that the hazards of ETS exposure that have been demonstrated in the home should not also apply to the workplace.
Abstract 3474: Formation of myosmine under oxidation of nicotine
Authors: Wolfgang Zwickenpflug, Christof Hoegg
Journal: Cancer Research (2010)

Abstract Nicotine and myosmine are alkaloids in tobacco products at which nicotine occurs in 200fold higher concentrations than myosmine. Nicotine is restricted on tobacco mainly, but myosmine is widespread in the biosphere and food materials additionally. Activation of nicotine showed amongst others N-nitrosation conversion to a compound class, the tobacco specific N-nitrosamines (TSNA). N’-nitrosonornicotine (NNN), 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol (NNAL) and 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) represent nicotine derived substances. These are assumed to be responsible for tumorigenesis and cancer disease, especially from the lung after activation to highly reactive intermediate species pyridyloxobutanone (POB). POB is known in the context of CYP 450 dependent activation of TSNA and was detected in DNA of tissues from laboratory animals, after TSNA application. The POB-DNA adducts release under hydrolysis 4-hydroxy-1-(3-pyridyl)-1-butanone (HPB) which was observed also during myosmine metabolism in rats, under N-nitrosation and under peroxidation procedures of this compound. Partially, nicotine and myosmine seem to be metabolized on similar way and support assumption from employment of identical CYP450 isozymes. Oxidation processes of nicotine and myosmine employing non CYP450 dependent systems undergoe different pathways involving N or N’ ring positions of their pyridine and pyrrole structures. Peroxidation of nicotine is reported under formation of nicotine N-oxides mainly. First results of finding higher myosmine contents in cigarette filter tips from smoked in relation to unburned cigarettes gave rise to deliberation of possible conversion of nicotine to myosmine. Following, (−)-nicotine in concentrations equivalent to amount in cigarettes 4.9-5.5µmol was incubated with hydrogen peroxide at 37°C and analyzed. To simulate the assumed reaction on biological systems, (−)-nicotine was incubated with horse radish peroxidase (HRP) and occurence of the relevant compounds analyzed. The assays were directly measured with high pressure liquid chromatography (HPLC) instrumentation and confirmed by cochromatography with respective standard compounds. Our results showed formation of myosmine under peroxidation from (−)-nicotine. This would mean conversion of nicotine to myosmine releases activated methyl-species, which could undergo protein or DNA methylation. This possible effect would indicate ability of nicotine to become activated not only as nitrosated but also as peroxidated species. Additional experiments are demanded to elucidate possible carcinogenic risk of nicotine conversion to myosmine. Acknowledgement: This work was supported by DFG grant 59/2-2 Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 101st Annual Meeting of the American Association for Cancer Research; 2010 Apr 17-21; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2010;70(8 Suppl):Abstract nr 3474.
Eosinophilic pneumonia as a presentation of occult chronic granulomatous disease
Authors: D Trawick, A Kotch, R Matthay, RJ Homer
Journal: European Respiratory Journal (1997)

We present a case of invasive pulmonary aspergillosis (IPA) in a previously healthy young woman who presented with what initially appeared to be an acute eosinophilic pneumonia. A second lung biopsy taken after treatment with steroids showed invasive Aspergillus with associated necrotizing granulomas, a pattern commonly found in chronic granulomatous disease (CGD). Both siblings, and by extrapolation, the patient, were actually found to have CGD. A review of the literature revealed other cases of presumed immunocompetent patients with IPA with presentations and lung histopathology similar to that of our patient. We conclude that chronic granulomatous disease presenting in the adult may be more common than previously assumed, and that patients previously presumed immunocompetent, but with granulomatous invasive pulmonary aspergillosis, may have chronic granulomatous disease. Furthermore, and most devastatingly in this case, the presentation may simulate a recently described steroid responsive acute lung disease, acute eosinophilic pneumonia.
695 EMODIN PROTECTS PRIMARY RAT HEPATOCYTES FROM PRO-OXIDATIVE EFFECTS AND AKT PATHWAY DYSREGULATION INDUCED BY A HIGH-FAT/LOW CARBOHYDRATE DIET
Authors: A. Alisi, F. Piemonte, G. Bruscalupi, A. Pastore, M. Massimi, G. Tozzi, S. Leoni, V. Nobili
Journal: Journal of Hepatology (2009)
STXBP1 promotes Weibel-Palade body exocytosis through its interaction with the Rab27A effector Slp4-a
Authors: Dorothee van Breevoort, Ambrosius P. Snijders, Nicola Hellen, Sarah Weckhuysen, Kathinka W. E. M. van Hooren, Jeroen Eikenboom, Karine Valentijn, Mar Fernandez-Borja, Berten Ceulemans, Peter De Jonghe, Jan Voorberg, Matthew Hannah, Tom Carter, Ruben Bierings
Journal: Blood (2014)
Pharmacological evidence for A1 and A2 adenosine receptors in the skin microcirculation.
Authors: I Stojanov, K G Proctor
Journal: Circulation Research (1989)

To characterize adenosine-mediated vascular responses, synthetic A1 and A2 receptor agonists (N-ethyl carboxamido adenosine [NECA], 2-chloro adenosine [2CA], or cyclohexyl adenosine [CHA]), the parent compound (adenosine [ADO]), an uptake inhibitor (dipyridamole [DIPYRID]) or a nonselective, competitive antagonist (8-phenyl theophylline [8pTHEO]) were topically applied to 20-60 microns arterioles in the subcutaneous microcirculation of the hamster. Blood flow was calculated from arteriolar diameter and red blood cell velocity using intravital microscopy. At greater than 10(-8) M, the potency order for vasodilation (maximum, 170-190% of control) was NECA greater than 2CA greater than ADO; these responses were attenuated by 10(-5) M 8pTHEO. From 10(-8) to 10(-6) M, 2CA evoked vasodilation whereas ADO, which has an identical affinity at A1 and A2 receptors, evoked lesser responses. ADO-induced vasodilation was potentiated by 10(-5) M DIPYRID; this response was similar to that evoked by 2CA alone or 2CA + DIPYRID. In contrast to ADO, 2CA is a poor substrate for cellular uptake, which suggests that uptake reduces the A2 effect of exogenous ADO. From 10(-10) to 10(-8) M, CHA and ADO were equipotent antagonized by 8pTHEO. Norepinephrine was a more potent vasoconstrictor and 8pTHEO did not alter these responses. Since ADO is a metabolic substrate and a nonselective receptor agonist, while CHA is A1-selective and a poor substrate for cellular uptake, neither A2 activation nor cellular uptake altered expression of the A1 effect of exogenous ADO. Furthermore, DIPYRID had no effect on the A1 response.(ABSTRACT TRUNCATED AT 250 WORDS)