THE ENCEPHALOPATHY OF HYPERINSULINISM
Authors: S. K. Fineberg, Alexander Altschul
Journal: Annals of Internal Medicine (1952)

Article1 February 1952THE ENCEPHALOPATHY OF HYPERINSULINISMS. K. FINEBERG, M.D., ALEXANDER ALTSCHUL, M.D., F.A.C.P.S. K. FINEBERG, M.D.Search for more papers by this author, ALEXANDER ALTSCHUL, M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-36-2-536 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptHyperinsulinism, in this discussion, is defined as the state produced by excessive amounts of insulin in the body, whether the insulin is exogenous or endogenous in origin. Although the term has been widely used since it was first proposed by Harris in 19241as indicative of the clinical state produced by excessiveendogenous(spontaneous) sources of insulin, as in hypertrophy, neoplasm or functional oversecretion of the islets of Langerhans, the far more frequent occurrence of the inadvertent administration of overdoses of insulin lays greater claim to the usage and application of a name so descriptively clear in its semantics. The...Bibliography1. Harris S: Hyperinsulinism and dysinsulinism, J. A. M. A. 83: 729 (Sept.) 1924. CrossrefGoogle Scholar2. Christopher F: A textbook of surgery, 3rd Ed., 1942, W. B. Saunders Company, Philadelphia, p. 1692. Google Scholar3. FabrykantBruger MM: Dynamics of the hypoglycemic reaction, Am. J. M. Sc. 216: 84 (July) 1948. MedlineGoogle Scholar4. MalamudGrosh NLC: Hyperinsulinism and cerebral changes, Arch. Int. Med. 61: 579 (Apr.) 1938. CrossrefGoogle Scholar5. Himwich HE: Review of hypoglycemia, Am. J. Digest. Dis. 11: 1 (Jan.) 1944. CrossrefGoogle Scholar6. FabrykantPacella MBL: Association of spontaneous hypoglycemia with hypocalcemia and electro-cerebral dysfunction, Proc. Am. Diabetes A. (1947) 7: 231, 1947. Google Scholar7. AllanCrommelin FNRM: Cerebral damage from insulin "shock," J. A. M. A. 118: 373 (Jan.) 1942. CrossrefGoogle Scholar8. Spencer AM: Post-hypoglycaemic encephalopathy in Sakel's insulin treatment, J. Ment. Sc. 94: 513 (July) 1948. CrossrefGoogle Scholar9. AltschulFineberg ASK: The encephalopathy of hyperinsulinism, Am. J. Digest. Dis. 16: 413 (Nov.) 1949. CrossrefMedlineGoogle Scholar10. Hill JM: Incontinence in acutely psychotic patients, Psychiatric Quart. 13: 294 (Apr.) 1939. CrossrefGoogle Scholar11. LayneBaker JAAB: Hypoglycemic cerebral damage in diabetic patients, Minnesota Med. 22: 771 (Nov.) 1939. Google Scholar12. Albright F: Osteoporosis, Ann. Int. Med. 27: 861 (Dec.) 1947. LinkGoogle Scholar13. Selye H: General adaptation syndrome and the diseases of adaptation, J. Clin. Endocrinol. 6: 117 (Feb.) 1946. CrossrefGoogle Scholar14. Smith JJ: Endocrine basis of hormonal therapy of alcoholism, New York State J. Med. 50: 1704 (July) 1950. Google Scholar15. GreerBeatty MAJH: Cerebral damage following insulin hypoglycemia, Stanford M. Bull. 5: 169 (Nov.) 1947. MedlineGoogle Scholar16. FerraroHervis AGA: Brain pathology in four cases of schizophrenia treated with insulin, Psychiatric Quart. 13: 207 (Apr.) 1939. CrossrefGoogle Scholar17. Kerwin AJ: Fatal hyperinsulinism with cerebral lesions due to pancreatic adenoma, Am. J. M. Sc. 203: 363 (March) 1942. CrossrefGoogle Scholar18. LawrenceMeyerNevin RDAS: The pathological changes in the brain in fatal hypoglycaemia, Quart. J. Med. 11: 181 (Oct.) 1942. Google Scholar19. EllenbergPollack MH: Convulsive state in diabetes, Am. J. M. Sc. 214: 503 (Nov.) 1947. CrossrefMedlineGoogle Scholar20. Bruch E: Recent progress in insulin physiology, Arch. Int. Med. 86: 427 (Sept.) 1950. CrossrefGoogle Scholar21. Duncan GG: Diseases of metabolism, 2nd Ed., 1947, W. B. Saunders Company, Philadelphia, p. 62. Google Scholar22. Yannet H: Experimental study of pathogenesis of cerebral changes following prolonged insulin hypoglycemia, Arch. Neurol. and Psychiat. 42: 395 (Sept.) 1939. CrossrefGoogle Scholar23. Allen FM: Spontaneous and artificial hyperinsulinism, J. Clin. Endocrinol. 1: 595 (July) 1941. CrossrefGoogle Scholar24. PriceCoriColowick WHCFSP: Effect of anterior pituitary extract and of insulin on hexokinase reaction, J. Biol. Chem. 160: 633 (Oct.) 1945. CrossrefMedlineGoogle Scholar25. ColowickCoriSlein SPGTMW: Effect of adrenal cortex and anterior pituitary extracts and insulin on hexokinase reaction, J. Biol. Chem. 168: 583 (May) 1947. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: New York, N. Y.*Received for publication July 9, 1951.From the Medical Service of The Harlem Hospital, New York, N. Y. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byDiabetes, Hypoglycaemia and Cognitive PerformanceCognitive function in diabetes mellitusDiabetes and Hypoglycaemia: Medicolegal Aspects of Criminal ResponsibilityRelationship Between High Fasting Blood Sugar and Depression in a Mental Hygiene Clinic Population *Morphologie cerebraler InsulinschädenFunctioning beta islet cell tumorsCorrelazioni fra alcune funzioni psiconeurologiche e livelli glicemici: Necessita' che nel diabetico il tessuto nervoso fruisca di livelli glicemici molto piu' elevati che nel normaleSevere hypoglycemia after the ingestion of a sulfonylurea compoundNONTROPICAL SPRUE AND FUNCTIONING ISLET-CELL ADENOMA OF THE PANCREAS: REPORT OF CASE*HAROLD H. SCUDAMORE, M.D., WILLIAM M. MCCONAHEY, M.D., F.A.C.P., JAMES T. PRIESTLEY, M.D., F.A.C.S.Contribution à l'étude électroencéphalographique des syndromes endocriniensProlonged Unconsciousness in Connection with an Attack of HypoglycemiaHormoneObservations on organic brain damage and clinical improvement following protracted insulin comaISLET CELL TUMOR OF THE PANCREAS WITH SURGICAL CURE*KARL PICKARD, M.D., F.A.C.P., JOSEPH J. KELTER, M.D., ROBERT E. ROTHENBERG, M.D., F.A.C.S.PITUITARY INSUFFICIENCY IN WOMEN 1 February 1952Volume 36, Issue 2_Part_2Page: 536-550KeywordsBrain diseasesHyperinsulinemiaInsulinMedical services ePublished: 1 December 2008 Issue Published: 1 February 1952 PDF downloadLoading ...