tbuckley/cabot-search huggingface dataset:
Meat, Meat Cooking Methods and Preservation, and Risk for Colorectal Adenoma
Authors: Rashmi Sinha, Ulrike Peters, Amanda J. Cross, Martin Kulldorff, Joel L. Weissfeld, Paul F. Pinsky, Nathaniel Rothman, Richard B. Hayes
Journal: Cancer Research (2005)

Abstract Cooking meat at high temperatures produces heterocyclic amines (HCAs) and polycyclic aromatic hydrocarbons (PAHs). Processed meats contain N-nitroso compounds. Meat intake may increase cancer risk as HCAs, PAHs, and N-nitroso compounds are carcinogenic in animal models. We investigated meat, processed meat, HCAs, and the PAH benzo(a)pyrene and the risk of colorectal adenoma in 3,696 left-sided (descending and sigmoid colon and rectum) adenoma cases and 34,817 endoscopy-negative controls. Dietary intake was assessed using a 137-item food frequency questionnaire, with additional questions on meats and meat cooking practices. The questionnaire was linked to a previously developed database to determine exposure to HCAs and PAHs. Intake of red meat, with known doneness/cooking methods, was associated with an increased risk of adenoma in the descending and sigmoid colon [odds ratio (OR), 1.26; 95% confidence interval (95% CI), 1.05-1.50 comparing extreme quintiles of intake] but not rectal adenoma. Well-done red meat was associated with increased risk of colorectal adenoma (OR, 1.21; 95% CI, 1.06-1.37). Increased risks for adenoma of the descending colon and sigmoid colon were observed for the two HCAs: 2-amino-3,8-dimethylimidazo[4,5]quinoxaline and 2-amino-1-methyl-6-phenylimidazo[4,5]pyridine (OR, 1.18; 95% CI, 1.01-1.38 and OR, 1.17, 95% CI, 1.01-1.35, respectively) as well as benzo(a)pyrene (OR, 1.18; 95% CI, 1.02-1.35). Greater intake of bacon and sausage was associated with increased colorectal adenoma risk (OR, 1.14; 95% CI, 1.00-1.30); however, total intake of processed meat was not (OR, 1.04; 95% CI, 0.90-1.19). Our study of screening-detected colorectal adenomas shows that red meat and meat cooked at high temperatures are associated with an increased risk of colorectal adenoma.
Systematic mutation screening of <i>KRT5</i> supports the hypothesis that Galli-Galli disease is a variant of Dowling-Degos disease
Authors: S. Hanneken, A. Rütten, S.M. Pasternack, S. Eigelshoven, L. El Shabrawi-Caelen, J. Wenzel, M. Braun-Falco, T. Ruzicka, M.M. Nöthen, R. Kruse, R.C. Betz
Journal: British Journal of Dermatology (2010)

Journal Article Systematic mutation screening of KRT5 supports the hypothesis that Galli–Galli disease is a variant of Dowling–Degos disease Get access S. Hanneken, S. Hanneken Department of Dermatology, University Hospital Düsseldorf, Moorenstrasse 5, 40225 Düsseldorf, Germany Sandra Hanneken. E‐mail:Hanneken@med.uni‐duesseldorf.de Search for other works by this author on: Oxford Academic Google Scholar A. Rütten, A. Rütten Laboratory of Dermatohistopathology, Friedrichshafen, Germany Search for other works by this author on: Oxford Academic Google Scholar S.M. Pasternack, S.M. Pasternack Institute of Human Genetics Search for other works by this author on: Oxford Academic Google Scholar S. Eigelshoven, S. Eigelshoven Department of Dermatology, University Hospital Düsseldorf, Moorenstrasse 5, 40225 Düsseldorf, Germany Search for other works by this author on: Oxford Academic Google Scholar L. El Shabrawi‐Caelen, L. El Shabrawi‐Caelen Department of Dermatology, Medical University of Graz, Graz, Austria Search for other works by this author on: Oxford Academic Google Scholar J. Wenzel, J. Wenzel Department of Dermatology Search for other works by this author on: Oxford Academic Google Scholar M. Braun‐Falco, M. Braun‐Falco Department of Dermatology, Ludwig‐Maximilian's University of Munich, Munich, Germany Search for other works by this author on: Oxford Academic Google Scholar T. Ruzicka, T. Ruzicka Department of Dermatology, University Hospital Düsseldorf, Moorenstrasse 5, 40225 Düsseldorf, GermanyDepartment of Dermatology, Ludwig‐Maximilian's University of Munich, Munich, Germany Search for other works by this author on: Oxford Academic Google Scholar M.M. Nöthen, M.M. Nöthen Institute of Human GeneticsDepartment of Genomics, Life & Brain Center, University of Bonn, Bonn, Germany Search for other works by this author on: Oxford Academic Google Scholar R. Kruse, R. Kruse Department of Dermatology, University Hospital Düsseldorf, Moorenstrasse 5, 40225 Düsseldorf, Germany Search for other works by this author on: Oxford Academic Google Scholar ... Show more R.C. Betz R.C. Betz Institute of Human Genetics Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 163, Issue 1, 1 July 2010, Pages 197–200, https://doi.org/10.1111/j.1365-2133.2010.09741.x Published: 01 July 2010
Dementia and Testosterone Levels in Men—Reply
Authors: Christian J. Pike, Emily R. Rosario, Frank Z. Stanczyk
Journal: JAMA (2005)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Abstract 14935: Impact of Paravalvular Regurgitation after Surgical Aortic Valve Replacement for Severe Aortic Stenosis: An Intraoperative Transesophageal Echocardiography Study
Authors: Hirotsugu Mihara, Javier Berdejo, Yuji Itabashi, Hiroto Utsunomiya, Michele A De Robertis, Alfredo Trento, Takahiro Shiota
Journal: Circulation (2014)

Introduction: Greater than mild paravalvular regurgitation (PVR) is reported to worsen late mortality after transcatheter aortic valve replacement (TAVR). However the impact of PVR on the prognosis after surgical aortic valve replacement (SAVR) is not determined. The purpose of this study was to investigate the impact of PVR on the prognosis after SAVR in patients with aortic stenosis (AS) using intraoperative transesophageal echocardiography (iTEE). Hypothesis: We hypothesized that the prognosis of mild PVR after SAVR in patients with AS is benign. Methods: We retrospectively reviewed 304 consecutive patients with severe AS who underwent isolated SAVR using bioprosthesis and who had color Doppler iTEE images after SAVR. Severity of PVR was determined by the sum of the cross-sectional area of the vena contracta (VCA) using 2D color Doppler just after SAVR. Grading of PVR was determined using the following VCA cutoffs: trivial 0-4 mm2; mild 5-9 mm2; moderate 10-29 mm2; severe ≥ 30 mm2. We investigated the clinical course after SAVR including death, re-hospitalization due to heart failure exacerbation, and reoperation. Results: The patients were 76 ± 10 years old, and 57% were male. PVR was trivial in 28 patients (9%), mild in 18 (6%), moderate in 9 (3%), severe in 0. During the follow-up period of 1111 ± 582 days (median 1071 days), there were significant differences in survival between moderate and none/trivial or mild PVR group (p &lt; 0.001 and 0.004, respectively). There was no significant differences in survival between mild and none/trivial PVR group (p = 0.69). Of 35 patients with ≥ mild PVR, only 3 patients with moderate PAR re-hospitalized for heart failure exacerbation and 1 of them resulted in successful percutaneous paravalvular leak closure. There was no other patient for reoperation except this patient. Conclusions: Although infrequent, moderate PVR showed worse survival following SAVR for severe AS, while the prognosis of mild PVR was benign.
First and second trimester fetal size and asthma outcomes at age ten years
Authors: Steve Turner, Nanda Prabhu, Rebecca Cutts, Peter Danielian, Keith Allen, Leone Craig, Geraldine McNeill, Peter Helms, Anthony Seaton, Graham Devereux
Journal: European Respiratory Journal (2011)

Introduction:  Longer early fetal size is associated with reduced asthma risk and improved lung function in early childhood but outcomes in later childhood have not been reported. Here we tested the hypothesis that associations between early fetal size, asthma symptoms and lung function persist into later childhood.   Methods:  In a longitudinal study, first and second trimester fetal measurements were recorded. At ten years of age a respiratory questionnaire was completed. Spirometry, bronchial challenge and skin prick testing were undertaken in a subset of children.   Results:  There were 1924 individuals recruited. Fetal measurements were available in the first trimester for 903 individuals and the second trimester for 1560. Questionnaires were returned for 927 children and 449 underwent detailed phenotyping. For each mm increase in first trimester size, asthma risk reduced by 7% [95% CI 1, 13] and FEV 1  was higher by an average of 6 mls [95% CI 1, 11]. First trimester size was reduced in those with asthma at both five and ten years compared to early or late onset asthma (p≤0.017). Persistent low growth in first and second trimesters was associated with increased risk for asthma (OR 3.2 [95% CI 1.2, 8.7]) and reduced FEV 1  (mean reduction 137mls [95% CI 21, 252]) compared to persistent high growth. Fetal size was not associated with bronchial responsiveness or atopy.   Conclusions:  Longer fetal size which is maintained during the first and second trimesters has an apparent protective effect on the development of persistent asthma and obstructive lung function and the underlying mechanism is independent of atopy.
Oncology trials—the elephant in the room
Authors: Rebecca Kirk, Lisa Hutchinson
Journal: Nature Reviews Clinical Oncology (2012)

Each year, when new annual cancer incidence and mortality statistics are published, the media are quick and happy to report that cancer mortality is reducing, despite some increases in incidence. There is a lot for the oncology community to celebrate and be proud of in these declining mortality rates and the decades of work that have produced them. However, late-phase clinical trials for anticancer drugs have the highest failure rates of all the clinical areas.1 Furthermore, those drugs that are successful often do not provide sufficient improvement on already available therapies, meaning that health-care providers often cannot afford to make them available to the patients they were designed for.2 Against this backdrop, it is time to discuss oncology clinical trials—the elephant in the room.
Arrhythmias in a Contemporary Fontan Cohort
Authors: Elizabeth A. Stephenson, Minmin Lu, Charles I. Berul, Susan P. Etheridge, Salim F. Idriss, Renee Margossian, John H. Reed, Ashwin Prakash, Lynn A. Sleeper, Victoria L. Vetter, Andrew D. Blaufox
Journal: Journal of the American College of Cardiology (2010)
Intranasal midazolam for febrile seizures
Authors: G. Koren
Journal: BMJ (2000)

Papers p 83 

Despite their benign nature and prognosis, uncomplicated febrile seizures are extremely stressful for both families and medical staff. Most parents believe that these seizures are harmful, and during the first episode half of all parents fear that their child is dying.1 For decades children were given long term anticonvulsant drugs to prevent the recurrence of febrile seizures. Although some of these are effective, their serious adverse effects have led to an unacceptable ratio of benefits to risks.2 3

There is, however, a broad consensus that febrile seizures should be treated promptly. Traditionally, benzodiazepines, barbiturates, or other anticonvulsants have been given intravenously, but rectally administered diazepam is now used as an efficacious alternative.

The intranasal administration of therapeutic agents is undoubtedly the centre of tremendous interest in the field of therapeutics. That there is extensive and prompt absorption of molecules through the nasal mucosa into a rich vascular bed has long been recognised by cocaine users.

In …
THE EFFECT OF THE PHYSICIAN'S "PSYCHE" UPON THE PATIENT'S "SOMA"
Authors: M D BOGDONOFF
Journal: Annals of Internal Medicine (1957)

Article1 May 1957THE EFFECT OF THE PHYSICIAN'S "PSYCHE" UPON THE PATIENT'S "SOMA"MORTON D. BOGDONOFF, M.D.MORTON D. BOGDONOFF, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-46-5-886 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe modern period of investigative psychosomatic medicine might be considered to have been initiated by Walter Cannon's studies on the physiology of rage and fear, and to have culminated in the detailed correlative studies of the rôle of emotions upon disease states. The impact of this large body of work has led to the widely taught and well accepted axiom that the patient's feelings, moods and attitudes may significantly influence the course of a given disorder. Less attention, however, has been accorded to the effect upon the course of an illness of the physician's attitudes and feelings toward the patient.... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Durham, North Carolina*Received for publication September 21, 1956.From the Department of Medicine, Duke University School of Medicine, Durham, North Carolina.Requests for reprints should be addressed to Morton D. Bogdonoff, M.D., The Physicians' Group, Physicians' Building, 1431 North Bayshore Drive, Miami 36, Florida. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byPsychological reactions to oral cancerThe Role of the Emotions in Respiratory Disease 1 May 1957Volume 46, Issue 5Page: 886-892KeywordsEmotionsFear ePublished: 1 December 2008 Issue Published: 1 May 1957 PDF downloadLoading ...
Successful DNA immunization against measles: Neutralizing antibody against either the hemagglutinin or fusion glycoprotein protects rhesus macaques without evidence of atypical measles
Authors: Fernando P. Polack, Sok H. Lee, Sallie Permar, Elizabeth Manyara, Hossein G. Nousari, Yaikah Jeng, Farah Mustafa, Alexandra Valsamakis, Robert J. Adams, Harriet L. Robinson, Diane E. Griffin
Journal: Nature Medicine (2000)
Note on the Catalase Activity of Several Mammalian Cell Strains After Long Cultivation &lt;italic&gt;In Vitro&lt;/italic&gt;
Authors: Ellison V. Peppers, Benton B. Westfall, Harold A. Kerr, Wilton R. Earle
Journal: JNCI Journal of the National Cancer Institute (1960)

The activity of the enzyme catalase was examined in 12 mammalian cell strains cultured for long intervals in vitro. Catalase activity of all cell strains was very low. Certain of the cultured cells were implanted into mice of the inbred strain from which the cells originated. The tumors arising from the implants, both of the sarcoma-producing strains and the one hepatoma-producing strain, had very low activity. The hepatoma-producing strain had much less activity than did spontaneous primary hepatomas excised directly from the mouse.
Who Cares About Tarawa?
Authors: AE Breland
Journal: JAMA (2000)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Activist Young Says "Gathering Storm" Will Propel a Single-Payer Movement
Authors: Q Young
Journal: JAMA (1998)

THE SENSE of health care déja vu was palpable. During the Gay and Lesbian Medical Association's annual symposium this August in Chicago, Quentin Young, MD, and Rep Barney Frank (D, Mass) debated the merits of a single-payer health care system in this country.
683. Cationic Mitochondriotropic Vesicles for DNA Delivery to Mitochondria
Authors: Volkmar Weissig, Gerard G. M. D'Souza
Journal: Molecular Therapy (2004)

The number of diseases found to be associated with defects of the mitochondrial genome has grown significantly since 1988. Despite major advances in understanding mtDNA defects at the genetic and biochemical level, there is no satisfactory treatment available for a vast majority of patients. Objective limitations of conventional biochemical treatment for patients with defects of mtDNA warrant the exploration of gene therapeutic approaches. Two different strategies for mitochondrial gene therapy are imaginable1 The first involves expressing a wild-type copy of the defective gene in the nucleus, with cytoplasmic synthesis and subsequent targeting of the gene product to the mitochondria (“allotopic expression”). Besides the different codon usage in mitochondria, however, there are possibly four major difficulties in adapting this nuclear-cytosolic approach for mitochondrial gene therapy to mammalian cells2. First, the majority of mtDNA defects involve tRNAs and to date, no natural mechanism has been reported for the mitochondrial uptake of cytosolic tRNAs in mammalian cells. Second, it is generally agreed that the thirteen proteins encoded for by mtDNA are very hydrophobic peptides, which would not be readily imported by the mitochondrial protein import machinery. However, since the 13 mitochondrial coded proteins are not equally hydrophobic, the allotopic expression of at least some of the peptides appears as possible3. Third, it has been hypothesized that some of the proteins encoded by the mitochondrion may potentially be toxic if synthesized in the cytosol4. Fourth, according to a hypothesis termed co-location for redox regulation5, the co-location of mtDNA and its products may be essential for the rapid control of gene expression by the redox state in the mitochondrial matrix. Considering all problems associated with the nuclear-cytosolic approach the development of methods for the direct transfection of mitochondria6 as an alternative approach towards mitochondrial gene therapy seems highly warranted. We have developed a strategy for mitochondrial gene therapy which involves the transport of a DNA-mitochondrial leader sequence peptide conjugate to mitochondria using cationic mitochondriotropic vesicles, the liberation of this conjugate from the cationic vector upon contact with the mitochondrial outer membrane followed by DNA uptake via the mitochondrial protein import machinery. For the design of cationic mitochondriotropic vesicles we have utilized the self-assembly behavior of dequalinium, a cationic single-chain bola-amphiphile which is known to selectively accumulate in mitochondria. We found that such bola-amphiphiles are able to form liposome-like cationic vesicles (“bolasomes”), which we termed “DQAsomes” when prepared from dequalinium7,8. Data will be presented showing that DQAsomes fulfill all essential prerequisites for a mitochondria-specific DNA delivery system.
Cancer Prevention in Primary Care: Melanoma: prevention and early diagnosis
Authors: J Austoker
Journal: BMJ (1994)

General practice is undergoing major changes and the profession needs to respond to these changes * One response could be the widespread involvement of general practitioners in higher professional training * At present only 1 in 300 general practitioners are enrolled on the seven general practice (or primary health care) master's degree courses in the United Kingdom * Present master's courses lack flexibility, have little student input to content, and could be less costly to students and have less emphasis on research * The provision and uptake of innovative and flexible master's courses should improve the quality of care that patients receive in general practice general practitioners taking such courses at present which could be ameliorated.It is suggested that course content needs to be more flexible to match more closely the needs of the learners.This can be achieved by increasing elective modules within courses.The option of not doing a formal thesis might help, as might the introduction of the requirement of possession of a relevant higher degree before appointment to various academic general practice posts.The personal financial cost to general practitioners could be reduced by including prolonged part time study leave as a claim- able expense within the NHS regulations, by ensuring all courses were approved for a postgraduate education allowance, increasing external funding of courses, and increasing the availability of paid research fellowship posts funded by departments of general practice or the Royal College of General Practitioners.Increasing the size of the cohort of appropriately trained general practitioners who can teach, research, and lead general practice into the next century should improve patient care throughout the primary care setting.