tbuckley/cabot-search huggingface dataset:
(11) ?Naevoid hidradenitis suppurativa ?acne naevus
Authors: M. Cheesbrough, B.R. Hughes
Journal: British Journal of Dermatology (1987)

Journal Article (11) ?Naevoid hidradenitis suppurativa ?acne naevus Get access M. Cheesbrough, M. Cheesbrough Huddersfield Royal Infirmary Search for other works by this author on: Oxford Academic Google Scholar B.R. Hughes B.R. Hughes The General Infirmary at Leeds Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 117, Issue s32, 1 June 1987, Pages 59–60, https://doi.org/10.1111/j.1365-2133.1987.tb12052.x Published: 01 June 1987
L-Thyroxine Therapy in Subclinical Hypothyroidism
Authors: DAVID S. COOPER
Journal: Annals of Internal Medicine (1984)

The indications for treating patients with subclinical hypothyroidism (normal serum thyroxine and free thyroxine levels, but elevated serum thyrotrophin levels) are poorly defined. In this study, 33 patients with subclinical hypothyroidism were randomly assigned in a double-blind manner to receive placebo or L-thyroxine therapy and were followed for 1 year with thyroid function tests, serum lipid measurements, basal metabolic rate and systolic time interval determinations, and a questionnaire on hypothyroid symptoms. The placebo group showed no changes in thyroid function or peripheral indices of thyroid hormone action. In the thyroxine-treated group, serum lipids and the mean systolic time interval did not change, but the systolic time intervals became normal in the 5 patients with the most abnormal baseline values. Symptoms improved in 8 of 14 patients receiving thyroxine and in 3 of 12 patients receiving placebo (p < 0.05). L-Thyroxine therapy may be useful for patients with subclinical hypothyroidism with abnormal myocardial contractility or symptoms consistent with mild hypothyroidism, or both.
Tubal Ligation, Hysterectomy, and Risk of Ovarian Cancer
Authors: Susan E. Hankinson
Journal: JAMA (1993)

To assess whether tubal ligation and hysterectomy affect subsequent risk of ovarian cancer.Prospective cohort study with 12 years of follow-up.United States, multistate.A total of 121,700 female registered nurses who were 30 to 55 years of age in 1976; the follow-up rate was 90% as of 1988.Ovarian cancer of epithelial origin confirmed by medical record review.We observed a strong inverse association between tubal ligation and ovarian cancer, which persisted after adjustment for age, oral contraceptive use, parity, and other ovarian cancer risk factors (multivariate relative risk [RR], 0.33; 95% confidence interval [CI], 0.16 to 0.64). The association was similar when we assessed tubal ligation status at the baseline questionnaire and excluded cases in the first 4 years to eliminate any possible short-term decrease in risk due to screening of the ovaries during ligation surgery. We noted a weaker inverse association between simple hysterectomy and ovarian cancer (RR, 0.67; 95% CI, 0.45 to 1.00). Neither vasectomy nor condom use by a partner was associated with risk of ovarian cancer.These data indicate that tubal ligation, and perhaps hysterectomy, may substantially reduce risk of epithelial ovarian cancer.
Respiratory dreams and nightmares.
Authors: N. Douglas
Journal: Thorax (1996)

Roger Altounyan played a major part in the development of inhaled prophylactic therapy for asthma.He pioneered the development of sodium cromoglycate by testing this agent, and many others, on his own asthma.His connec- tion with my theme today is somewhat tenuous, and the best I could find relates to the fact that, as a child, he was the role model for Roger in Arthur Ransom's Swallows and Ama- zons in which appears:"Susan said 'Roger, you had better go to sleep.'There was no answer.Roger was already asleep".'While this somnolence was due to childhood exertion, I wish to focus on the sleep apnoea/hypopnoea syndrome as a major cause of somnolence in adults and children.
Successful biliary stenting and sphincterotomy using an ultrathin forward-viewing endoscope
Authors: S.-L. Yan, C.-H. Chen, Y.-H. Yeh, S.-K. Yueh
Journal: Endoscopy (2009)

Some complications of endoscopic retrograde cholangiopancreatography (ERCP) including cardiovascular stress may be related to the use of large-caliber endoscopes [1] [2]. Procedures with the ultrathin endoscope have been shown to be better tolerated and require less sedation than conventional esophagogastroduodenoscopy [3]. Furthermore, transnasal ERCP utilizing an ultrathin endoscope has been shown to cause less cardiovascular stress [4]. ERCP using the ultrathin endoscope seems to be a promising alternative method, especially for those with a high risk of cardiovascular events. However, therapeutic ERCP procedures, such as biliary stenting or sphincterotomy, via an ultrathin forward-viewing endoscope have not been currently reported. We present here a first case report of successful biliary stenting and sphincterotomy using an ultrathin forward-viewing endoscope.
Parenteral administration of recombinant human neuregulin‐1 to patients with stable chronic heart failure produces favourable acute and chronic haemodynamic responses
Authors: Andrew Jabbour, Christopher S. Hayward, Anne M. Keogh, Eugene Kotlyar, Jane A. McCrohon, John F. England, Raul Amor, Xifu Liu, Xin Yan Li, Ming Dong Zhou, Robert M. Graham, Peter S. Macdonald
Journal: European Journal of Heart Failure (2010)
Selectivity of Protein Excretion in Patients with the Nephrotic Syndrome*
Authors: Gary R. Joachim, J. Stewart Cameron, Melvin Schwartz, E. Lovell Becker
Journal: Journal of Clinical Investigation (1964)

this relationship has been expressed graphically as a straight line whose slope characterizes the degree of selective excretion of large or small protein molecules (Figure .1).A steep slope de- notes selective filtration of small molecules, and thus suggests that the size of the glomerular "defect" is correspondingly small.Selectivity patterns of protein excretion were determined and then compared with response to steroid therapy and renal pathology in individual patients.In addition, the patterns were corre- lated with blood urea nitrogen, inulin and paraaminohippuric acid clearances, total 24-hour uri- nary protein, and duration of disease.The re- sults show that those patients with the nephrotic syndrome secondary to intrinsic renal disease (primary renal disease group), demonstrating a high degree of selective protein excretion before treatment, appear to respond best to steroid ther- apy, irrespective of the histologic findings.Fur- thermore, the selectivity pattern remained fairly constant for a given patient even though the total daily urinary protein excretion was fluctuating.Although no characteristic selectivity pattern was found for any given pathologic group, those patients with more advanced histologic changes in the glomeruli appeared to have the least selective type of proteinuria. MethodsStudies were carried out in 48 patients (23 males, 25 females).Forty-five satisfied Berman and Schreiner's criteria for the nephrotic syndrome (8).Their ages ranged from 16 to 66 years with a median of 31 years, and the duration of illness ranged from 2 to 182 months with a median of 21 months.Renal biopsy was per- formed in 36 patients.Of the 12 patients not biopsied, the diagnosis was inferred in three who had diabetes mellitus, and in one patient in whom a unilateral renal vein thrombosis was demonstrated.Two patients with acute proliferative glomerulonephritis and one who was 2332
Oxytocic Injections by Midwives
Authors: W. J. Clancy
Journal: BMJ (1942)

M B RITISHposterior sacro-iliac and the interosseous sacro-iliac ligaments), and by equally powerful accessory ligaments (namely, the ilio- lumbar, the sacro-spinous, and sacro-tuberous ligaments); (2) by muscles which span the joint-for example, multifidus, sacro- spinalis, gluteus maximus, piriformis, and iliacus; (3) by an ingenious interlocking device between the articular surfaces (one of the most important factors in stabilizing the joint and not referred to by the author).While Dr. Cyriax mentions that the laxity which sometimes occurs at this joint does not affect men, he offers no explanation of the fact.The explanation is that this joint needs to be stable in men in order to withstand the strain of hard manual work, while it needs to be mobile in women in order to perform the function of child-bearing.The joint therefore tends to ossify early in men, but I have yet to see it ossify in women at any age.-Iam, etc., Birmingham.C. F. V. SMOUT.
pH Optima in Immune Hemolysis: A Comparison between Guinea Pig and Human Complement *
Authors: Stanley Yachnin, Janet M. Ruthenberg
Journal: Journal of Clinical Investigation (1965)

1 The following abbreviations are used: C', complement; C'Hso, 50% hemolytic unit of complement; C'1, C'2, C'3, C'4, the first, second, third, or fourth component of com- plement; C'la, activated first component of complement; R3, serum lacking the third component of complement; E, sheep red cells; A, antibody or amboceptor; EA, sensitized sheep red cells; EAC' . .., sensitized
Collagenous Duodenitis and Collagenous Colitis: A Short Clinical Course as Evidenced by Sequential Endoscopic and Histologic Findings
Authors: F. S. Schreiber, S. Eidt, M. Hidding, J. Schmidt-Walczuch, C. Werning
Journal: Endoscopy (2001)

A 25-year-old male patient complained of mucoid, watery and nonbloody diarrhea for 4 weeks. Stool volumes and frequency (5 - 20 per day) varied. Furthermore, he suffered from cramping abdominal pain and weight loss of 10 kg. Physical examination was normal except for the patient’s fatigued appearance.
Interleukin 1 beta induces matrix metalloproteinase expression in human aortic valve myofibroblasts in vitro and promotes cell proliferation
Authors: Jens J. Kaden, Refika Kilic, Aslihan Sarikoc, Karl K. Haase, Carl-Erik Dempfle, Martin Borggrefe
Journal: Journal of the American College of Cardiology (2003)
Hazards of pharmacological tests of growth hormone secretion.
Authors: D. A. Price
Journal: BMJ (1992)

reports (b) "medical records" and "patient education"; (c) administration of drugs, there is no equivalent for "medical records" and "attitude to health"; (d) documenting problems after investigations and SIR,-All learned journals require that their "4medical records" and "patient participation"; alerting the medical community of associated authors have satisfactorily reviewed published or (e) "medical records" and "health education."risks, and thus their report is valuable.It is well work.Over the past decade there have been several(A list of 101 references on the subject of patients' known among growth specialists, however, that critcal evies o autors'use f satisics'and access to records, of which 53 are to original insulin induced hypoglycaemia is potentially recommendations to try to tighten up the use and research, is available.)dangerous, and at least one child was previously
IS MITRAL ANNULUS EARLY DIASTOLIC VELOCITY A CLINICALLY RELEVANT INDEX OF LEFT VENTRICULAR RELAXATION?
Authors: Zoran Popovic, Milind Y. Desai, Adisai Buakhamsri, Chirapa Puntawagkoon, Allen Borowski, Benjamin D. Levine, Wai Hong Wilson Tang, James D. Thomas
Journal: Journal of the American College of Cardiology (2010)
Is Leukoreduction of Blood Components for Everyone?
Authors: Howard L. Corwin, James P. AuBuchon
Journal: JAMA (2003)

docarditis: a 10-year comparative analysis. Circulation. 1978;58:589-597. 7. McAnulty JH, Rahimtoola SH. Surgery for infective endocarditis. JAMA. 1979; 242:77-79. 8. Wilson WR, Giuliani ER, Danielson GK, Geraci JE. Management of complications of infective endocarditis. Mayo Clin Proc. 1982;57:162-170. 9. DiNubile MJ. Surgery in active endocarditis. Ann Intern Med. 1982;96:650659. 10. Alsip SG, Blackstone EH, Kirklin JW, Cobbs CG. Indications for cardiac surgery in patients with active infective endocarditis. Am J Med. 1985;78(suppl 6B): 138-148. 11. Delahaye F, Ecochard R, de Gevigney G, et al. The long term prognosis of infective endocarditis. Eur Heart J. 1995;16(suppl B):48-53. 12. Moon MR, Stinson EB, Miller DC. Surgical treatment of endocarditis. Prog Cardiovasc Dis. 1997;40:239-264. 13. Alexiou C, Langley SM, Stafford H, et al. Surgery for active culture-positive endocarditis: determinants of early and late outcome. Ann Thorac Surg. 2000;69: 1448-1454. 14. Middlemost S, Wisenbaugh T, Meyerowitz C, et al. A case for early surgery in native left-sided endocarditis complicated by heart failure: results in 203 patients. J Am Coll Cardiol. 1991;18:663-667. 15. Jault F, Gandjbakhch I, Rama A, et al. Active native valve endocarditis: determinants of operative death and late mortality. Ann Thorac Surg. 1997;63:17371741. 16. Yusuf S, Zucker D, Peduzzi P, et al. Effect of coronary artery bypass graft surgery on survival: overview of 10-year results from randomized trials by the Coronary Artery Bypass Graft Surgery Trialists Collaboration. Lancet. 1994;344:563570. 17. Hasbun R, Vikram HR, Barakat LA, Buenconsejo J, Quagliarello VJ. Complicated left-sided native valve endocarditis in adults: risk classification for mortality. JAMA. 2003;289:1933-1940. 18. Fine MJ, Auble TE, Yealy DM, et al. A prediction rule to identify low-risk patients with community-acquired pneumonia. N Engl J Med. 1997;336:243-250. 19. Tischler MD, Vaitkus PT. The ability of vegetation size on echocardiography to predict clinical complications. J Am Soc Echocardiogr. 1997;10:562-568. 20. De Castro S, Magni G, Beni S, et al. Role of transthoracic and transesophageal echocardiography in predicting embolic events in patients with active infective endocarditis involving native cardiac valves. Am J Cardiol. 1997;80:1030-1034.
Screening for Abdominal Aortic Aneurysm
Authors: Amber-Nicole Bird, Andrew M. Davis
Journal: JAMA (2015)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Effects of Thiazide Diuretic Therapy on Bone Mass, Fractures, and Falls
Authors: Jane A. Cauley
Journal: Annals of Internal Medicine (1993)

Objective: To determine the relation between the use of thiazide diuretics and bone mass, fractures, and falls in older women. Design: Cross-sectional study of thiazide diuretics, bone mass, and prevalent vertebral deformities; cohort analysis of thiazide diuretics and nonspinal fractures and falls. Setting: Four clinical centers located in Baltimore, Maryland; Minneapolis, Minnesota; Portland, Oregon; and the Monongahela Valley, Pennsylvania. Participants: A total of 9704 ambulatory, nonblack women who were 65 years or older. Measurements: Information on thiazide use, demographic data, medical history, and anthropometric measurements were obtained by questionnaire, interview, and examination. Appendicular bone mass was measured by single-photon absorptiometry. Incident falls and fractures were ascertained every 4 months. Results: Women using thiazide diuretics for more than 10 years had significantly higher bone mass than women who had never used thiazide diuretics (for example, 0.381 g/cm2 compared with 0.355 g/cm2 for the distal radius [P < 0.001]). Current users of thiazide diuretics had an incidence of falls (relative risk, 1.06; 95% CI, 0.90 to 1.25) that was similar to that of those who had never used these drugs. After adjusting for age, body weight, functional status, total calcium intake, duration of estrogen replacement therapy, and self-reported health status, we found that current users of thiazide diuretics who had taken these drugs for more than 10 years had a risk for nonspinal (relative risk, 0.99; CI, 0.81 to 1.20) and osteoporotic (relative risk, 0.98; CI, 0.79 to 1.22) fractures that was similar to that of women who had never used thiazides; however, thiazide users did have a lower risk for fractures of the hip (relative risk, 0.63; CI, 0.34 to 1.16) and wrist (relative risk, 0.66; CI, 0.40 to 1.08), neither of which was significant. Conclusions: Thiazide diuretics have no effect on a woman's risk for falling or for experiencing nonspinal fractures. The trend toward a lower risk for hip and wrist fractures is consistent with findings in previous cohort studies but may reflect selection factors for the use of thiazide diuretics. A randomized trial is needed to determine the effect of thiazide diuretics on the incidence of fractures. From the University of Pittsburgh, Pittsburgh, Pennsylvania; the University of California, San Francisco, California. *Members and participating institutions are listed in the Appendix. For current author addresses, see end of text.
Effect of practolol on the extent of myocardial ischaemic injury after experimental coronary occlusion and its effects on ventricular function in the normal and ischaemic heart
Authors: P. LIBBY, P. R. MAROKO, J. W. COVELL, C. I. MALLOCH, J. ROSS, E. BRAUNWALD
Journal: Cardiovascular Research (1973)

Epicardial electrocardiographic maps were used to assess the effect of practolol (2·5 mg/kg) on the extent and severity of myocardial ischaemic injury after acute coronary artery occlusion in dogs. The average ST segment elevation and number of sites with abnormally elevated ST segments were significantly reduced 15 min following occlusion after practolol pretreatment when compared with a previous 20 min control occlusion (4·7 ± 0·5 to 2·9 ± 0·6 mV and 8·4 ±0·3 to 5·1 ±0·7, respectively). Analysis of ventricular function in normal conscious animals indicated a lack of myocardial depressant effect of practolol, and this finding was confirmed in the group subjected to coronary occlusions.
Detection of cell cycle- and differentiation stage-dependent human telomerase reverse transcriptase expression in single living cancer cells
Authors: Anna Edqvist, Johan Rebetz, Marcus Järås, Anna Rydelius, Gunnar Skagerberg, Leif G. Salford, Bengt Widegren, Xiaolong Fan
Journal: Molecular Therapy (2006)

Elevated telomerase activity is an important molecular signature of cancer cells and primitive cells in regenerative tissues. However, isolation of single living cells with endogenous telomerase activity has not yet been possible. Here, we developed adenovirus serotype 35 tropism-based vectors encoding destabilized enhanced green fluorescence protein with a half-life of 2 h (d2EGFP) driven by the human telomerase reverse transcriptase (hTERT) promoter. As assessed in telomerase-positive or -negative cell lines, the d2EGFP expression positively correlated with hTERT transcript content and telomerase activity. In retinoic acid-induced differentiating HL-60 cells, the d2EGFP expression is diminished in the same manner as the hTERT expression. Individual cells from HeLa and HL-60 cell lines exhibited heterogeneous d2EGFP expression, which was cell cycle dependent, as the sorted d2EGFP+ HL-60 cells contained twice as many cells in S/G2/M phase of the cell cycle compared with the d2EGFP− HL-60 cells. However, both cell populations exhibited the same proliferation and regeneration capacities. Heterogeneous d2EGFP expression was also detected in xenograft glioblastoma multiforme cells with tumor formation capacity. Thus, d2EGFP expression reported cell cycle- and differentiation stage-dependent hTERT expression. Our study facilitates isolation and characterization of single living cells with telomerase activity.
In vivo conditioning of acid–base equilibrium by crystalloid solutions: an experimental study on pigs
Authors: T. Langer, E. Carlesso, A. Protti, M. Monti, B. Comini, L. Zani, D. T. Andreis, G. E. Iapichino, D. Dondossola, P. Caironi, S. Gatti, L. Gattinoni
Journal: Intensive Care Medicine (2012)
Long-term efficacy and safety of endotherapy for management of biliary anastamotic strictures following liver transplantation
Authors: S. Putta, V. Sagar, B. Gunson, G. Haydon, D. Freshwater, A. Holt, S. Pathmakanthan, J. Ferguson
Journal: Gut (2011)

<h3>Introduction</h3> Biliary anastomotic strictures are among the commonest biliary complications following liver transplantation. Endoscopic therapy including balloon dilatation of stricture and maximal stent placement, is widely used as the preferred means of managing these patients.12 However, endoscopic therapy is not standardized and there is very limited prospective data to support the long-term efficacy of this approach. The aim of our study is to assess the safety and long-term efficacy of endotherapy in the management of biliary anastamotic strictures complicating liver transplantation. <h3>Methods</h3> This was a prospective observational study carried out at the liver transplantation unit, Queen Elizabeth Hospital, Birmingham, United Kingdom, between June 2000 and September 2010. In June 2000, the liver transplant unit in Birminghamintroduced a new protocol for managing biliary anastamotic strictures complicating orthotopic liver transplantation. The new protocol entailed a sequence of clearly defined clearly defined endoscopic interventions including balloon dilatations and stent insertions at regular intervals. A total of 1414 adult patients underwent liver transplantation. 81 (6%) patients were diagnosed with biliary anastomotic strictures during this period. <h3>Results</h3> Endoscopic therapy was successful in 61% of patients referred with anastomotic strictures with a median intervention/stent free follow-up of 54 months. Patients required a median of 3 endoscopic procedures and two 24 F balloon dilatations to adequately treat the stricture. Three patients (3%) had recurrent stricture and two of these were successfully retreated with endotherapy. A total of 261 endoscopic procedures were undertaken and complications included mild to moderate pancreatitis (n = 9), Cholangitis (n = 4) and stent migration (n = 2). The rate of pancreatitis per endoscopic procedure was 3%. Severe pancreatitis or death were not reported. Twenty patients underwent biliary reconstruction. <h3>Conclusion</h3> We report one of the very few prospective studies looking at the long-term efficacy and safety of endoscopic therapy in the management of anastamotic biliary strictures. Endoscopic balloon dilatation and stenting is a safe and efficacious means of treating biliary anastomotic strictures complicating liver transplantation.