SERUM GLUTAMIC OXALACETIC TRANSAMINASE ACTIVITY AS AN INDEX OF LIVER CELL INJURY: A PRELIMINARY REPORT
Authors: F WROBLEWSKI, J S LADUE
Journal: Annals of Internal Medicine (1955)

Article1 August 1955SERUM GLUTAMIC OXALACETIC TRANSAMINASE ACTIVITY AS AN INDEX OF LIVER CELL INJURY: A PRELIMINARY REPORTFELIX WRÓBLEWSKI, M.D., JOHN S. LADUE, M.D., Ph.D., F.A.C.P.FELIX WRÓBLEWSKI, M.D., JOHN S. LADUE, M.D., Ph.D., F.A.C.P.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-43-2-345 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptINTRODUCTIONGlutamic oxalacetic transaminase is widely distributed in animal tissues. Its greatest concentration, however, is in heart muscle, skeletal muscle, brain, liver and kidney, in decreasing order.1 We have already shown that, when measured in serum, this enzyme is elevated after acute myocardial infarction.2 This finding led us to study its concentration in liver diseases, since the enzyme is present in relatively high concentration in liver.Glutamic oxalacetic transaminase is present in all human sera and will henceforth be referred to as SGO-T. Comparable concentrations are found whether chromatographic or spectrophotometric methods are employed.3When serum is added to excesses...Bibliography1. AwaparaSeale JH: Distribution of transaminase in rat organs, J. Biol. Chem. 194: 497, 1952. CrossrefMedlineGoogle Scholar2. LaDueWróblewskiKarmen JSFA: Serum glutamic oxalacetic transaminase activity in human acute transmural myocardial infarction, Science 120: 497, 1954. CrossrefMedlineGoogle Scholar3. KarmenWróblewskiLaDue AFJS: Transaminase activity in human blood, J. Clin. Investigation 34: 126, 1955. CrossrefMedlineGoogle Scholar4. NydickWróblewskiLaDue IFJS: Evidence for increased serum glutamic oxalacetic transaminase activity following graded myocardial infarction in dogs, in press (Circulation). Google Scholar5. WróblewskiLaDue FJS: Serum glutamic oxalacetic transaminase activity as an index of liver destruction and disease, Clin. Res. Proc. 3. Google Scholar6. MolanderWróblewskiLaDue DFJS: Transaminase compared with cholinesterase and alkaline phosphatase as an index of hepatocellular integrity in the white rat, Clin. Res. Proc. 3. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: New York, N. Y.*Received for publication April 13, 1955.From the Sloan-Kettering Institute, Division of Clinical Investigation, and the Medical Service of the Memorial Center for Cancer and Allied Diseases, New York, N. Y.†Supported in part by a grant from the National Institutes of Health. 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