tbuckley/cabot-search huggingface dataset:
Isoniazid and Liver Injury
Authors: LAURENCE S. FARER
Journal: Annals of Internal Medicine (1976)

Comments and Corrections1 June 1976Isoniazid and Liver InjuryLAURENCE S. FARER, M.D.LAURENCE S. FARER, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-84-6-753 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: I wish to comment on a possible misinterpretation of the data presented by Dr. Zimmerman in the NIH Conference published in the February issue (1). He describes the characteristics of clinically overt hepatic injury in 114 patients reported by Black, Mitchell, and Zimmerman (2), and indicates that 13 of the 114 (12%) died. Most of the 114 cases studied by Black's group came from the U.S. Public Health Service prospective surveillance of 13 838 isoniazid recipients in cities across the United States. However, the authors added 27 other patients, accounting for 6 of the 13 fatalities in...References1. MITCHELLZIMMERMANISHAK JHK: Isoniazid liver injury: clinical spectrum, pathology, and probable pathogenesis. Ann Intern Med 84:181-192, 1976 LinkGoogle Scholar2. BLACKMITCHELLZIMMERMAN MJH: Isoniazid-associated hepatitis in 114 patients. Gastroenterology 69:289-302, 1975 CrossrefMedlineGoogle Scholar3. : Preventive therapy of tuberculous infection. Am Rev Respir Dis 110:371-374, 1974 MedlineGoogle Scholar4. COMSTOCKEDWARDS GP: The competing risks of tuberculosis and hepatitis for adult tuberculin reactors (editorial). Am Rev Respir Dis 111:573-577, 1975 MedlineGoogle Scholar1. ZIMMERMAN H: Drug-induced hepatic injury, in Hypersensitivity to Drugs, IEPT section 75, edited by SAMTER M, PARKER CW. New York, Pergamon Press, Inc., 1972, pp. 299-365 Google Scholar2. GARIBALDIDRUSINFEREBEE RRS: Isoniazid-associated hepatitis: report of an outbreak. Am Rev Respir Dis 106:357-365, 1972 CrossrefMedlineGoogle Scholar3. MADDREYBOITNOTT WJ: Isoniazid hepatitis. Ann Intern Med 79:1-12, 1973 LinkGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Tuberculosis Control Division Bureau of State Services Center for Disease Control Atlanta, GA 30333 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByOther Antibacterial Drugs 1 June 1976Volume 84, Issue 6Page: 753-754KeywordsIsoniazidLiverMedical services Issue Published: 1 June 1976 PDF DownloadLoading ...
PROSPECTIVE VALIDATION BY INTRAVASCULAR ULTRASOUND WITH RADIOFREQUENCY BACKSCATTER THAT HIGHER PLAQUE VOLUME AND FIBRO-FATTY TISSUE AND LESS DENSE CALCIUM IS ASSOCIATED WITH MAJOR ADVERSE CARDIOVASCULAR EVENTS
Authors: Abhinav Sharma, Parag H. Joshi, Gustavo Vazquez, Zhen Qian, Torrance Laury, Ambar Bajpai, Sarah Rinehart, Dimitri Karmapaliotis, Szilard Voros
Journal: Journal of the American College of Cardiology (2011)
French GPs launch organ donor campaign
Authors: A. Dorozynski
Journal: BMJ (1995)

About 10 000 French general practitioners have agreed to participate in a campaign to encourage their patients to donate organs after their death. Posters are being placed in waiting rooms, stating, “Your doctor has volunteered for organ donation. Ask him why.”

The doctors have also received a brochure giving practical, legal, and statistical information to help patients understand the importance of organ donation, and a volunteer donor card that will be given to all adult patients aged under 55 who agree to donate their organs after death.

The campaign has been prompted by an unprecedented shortage of organs resulting from an increase in the number of families that …
EVALUATION OF DIASTOLIC FUNCTION BY CARDIAC MAGNETIC RESONANCE IMAGING USING A NOVEL FEATURE TRACKING TECHNIQUE AND COMPARISON WITH ECHOCARDIOGRAPHY IN HEALTHY SUBJECTS
Authors: Deepu Alexander, Rena Toole, Kathleen Bertman, Florentina Petillo, Michael Passick, Simcha Pollack, Eddy Barasch, Madhavi Kadiyala
Journal: Journal of the American College of Cardiology (2012)
Linkage of the potent leukemogenic activity of Meis1 to cell-cycle entry and transcriptional regulation of cyclin D3
Authors: Bob Argiropoulos, Eric Yung, Ping Xiang, Chao Yu Lo, Florian Kuchenbauer, Lars Palmqvist, Carola Reindl, Michael Heuser, Sanja Sekulovic, Patty Rosten, Andrew Muranyi, Siew-Lee Goh, Mark Featherstone, R. Keith Humphries
Journal: Blood (2010)
Updated Guidelines for Management of High Blood Pressure
Authors: Howard Bauchner, Phil B. Fontanarosa, Robert M. Golub
Journal: JAMA (2013)

Hypertension is a common major risk factor for cardiovascular disease and stroke.It is estimated that in 2010, nearly 78 million US adults (aged ≥20 years) had high blood pressure, but in approximately 50%, hypertension was not adequately controlled. 1 Most patients with hypertension are treated by primary care physicians; treatment is effective and includes both lifestyle interventions and relatively inexpensive medications.The importance of detecting and treating hypertension is well-recognized by professional societies and federal agencies.In their article published in JAMA, the panel members appointed to the Eighth Joint National Committee (JNC 8) report their Evidence-Based Guideline for the Management of High Blood Pressure in Adults. 2 This guideline has been long-awaited and much anticipated, with the last revision of the blood pressure guidelines, the JNC 7 report, having been published in JAMA in 2003. 3An update of this decade-old guideline is overdue, considering that about half of the major recommendations in guidelines become outdated in approximately 6 years. 4s the panel members describe in the report, 2 the JNC 8 committee was appointed in 2008 by the National Heart, Lung, and Blood Institute (NHLBI) and was charged with reviewing and synthesizing the most recent available scientific evidence, updating existing clinical recommendations, and providing guidance for clinicians on the best approaches to manage and control high blood pressure to minimize the risk of cardiovascular events and other complications.The panel used rigorous evidence-based methods and developed evidence statements and recommendations for blood pressure treatment based on a systematic review of available randomized controlled trials.The panel focused on 3 critical questions that address thresholds and goals for pharmacologic treatment of hypertension: (1) in adults with hypertension, does initiating antihypertensive pharmacologic therapy at specific blood pressure thresholds improve health outcomes?(2) in adults with hypertension, does treatment with antihypertensive pharmacologic therapy to a specified blood pressure goal lead to improvements in health outcomes?and (3) in adults with hypertension, do various antihypertensive drugs or drug classes differ in comparative benefits and harms on specific health outcomes?In addition to the 9 recommendations and the treatment algorithm based on their systematic review of the evidence and included in their article, 2 the authors also provide the comprehensive evidence review and methods in an online supplement.Importantly, despite the care in formulating their evidence-based guideline, the panel members clearly acknowledge that their recommendations are not a substi-
Gastroduodenal Involvement, With Pain, Vomiting, and Weight Loss
Authors: Azam Ansari
Journal: JAMA (1976)

<h3>History</h3> A 52-year-old woman complained of epigastric pain, early satiety, post-prandial vomiting, and weight loss of six months' duration. An upper gastrointestinal roentgenographic series was performed (Fig 1 and 2). Two years earlier she had undergone abdominal surgery for a related illness. <h3>Diagnosis</h3> Crohn disease of the stomach and duodenum. <h3>Comment</h3> Figures 1A and B demonstrate rigidity, narrowing, and irregularity of the antrum, pylorus, and duodenum. A "cobblestone" or "string of pearls" appearance of the mucosa in the body of the stomach is clearly seen in Fig 1C and D and 2. Figure 3 shows pseudopolypoid nodulation of the mucosa in the resected specimen of the stomach that closely parallels with the roentgenographic pattern shown in Fig 1C and D. Figure 4 illustrates the histologic appearance, showing foci of chronic inflammatory reaction in the submucosa. Granulomas are easily identified and contain many giant cells. No central caseation nor acid-fast bacilli
Exome-wide Rare Variant Analysis Identifies TUBA4A Mutations Associated with Familial ALS
Authors: Bradley N. Smith, Nicola Ticozzi, Claudia Fallini, Athina Soragia Gkazi, Simon Topp, Kevin P. Kenna, Emma L. Scotter, Jason Kost, Pamela Keagle, Jack W. Miller, Daniela Calini, Caroline Vance, Eric W. Danielson, Claire Troakes, Cinzia Tiloca, Safa Al-Sarraj, Elizabeth A. Lewis, Andrew King, Claudia Colombrita, Viviana Pensato, Barbara Castellotti, Jacqueline de Belleroche, Frank Baas, Anneloor LMA ten Asbroek, Peter C. Sapp, Diane McKenna-Yasek, Russell L. McLaughlin, Meraida Polak, Seneshaw Asress, Jesús Esteban-Pérez, José Luis Muñoz-Blanco, Michael Simpson, Wouter van Rheenen, Frank P. Diekstra, Giuseppe Lauria, Stefano Duga, Stefania Corti, Cristina Cereda, Lucia Corrado, Gianni Sorarù, Karen E. Morrison, Kelly L. Williams, Garth A. Nicholson, Ian P. Blair, Patrick A. Dion, Claire S. Leblond, Guy A. Rouleau, Orla Hardiman, Jan H. Veldink, Leonard H. van den Berg, Ammar Al-Chalabi, Hardev Pall, Pamela J. Shaw, Martin R. Turner, Kevin Talbot, Franco Taroni, Alberto García-Redondo, Zheyang Wu, Jonathan D. Glass, Cinzia Gellera, Antonia Ratti, Robert H. Brown, Vincenzo Silani, Christopher E. Shaw, John E. Landers, Sandra D’Alfonso, Letizia Mazzini, Giacomo P. Comi, Roberto Del Bo, Mauro Ceroni, Stella Gagliardi, Giorgia Querin, Cinzia Bertolin
Journal: Neuron (2014)
Immunoglobulins on the Surface of Lymphoid Cells in Waldenström's Macroglobulinemia
Authors: Jean-Louis Preud'homme, Maxime Seligmann
Journal: Journal of Clinical Investigation (1972)

Immunofluorescence study of viable and fixed cells was performed on marrow and blood samples from 25 patients with Waldenström's macroglobulinemia. Whereas intracytoplasmic staining for IgM was restricted to the plasma cells and to a limited number of lymphocytic cells, the vast majority of the pleomorphic “lymphoid” proliferating cells in the marrow were shown to bear the monoclonal IgM on their surface. All IgM-secreting plasma cells displayed membrane positivity. Most lymphocytic proliferating cells carried the monoclonal IgM on their surface in the absence of detectable amounts of intracytoplasmic IgM. Despite the usual absence of increase in blood lymphocyte counts, a large number of circulating lymphocytes were shown to bear membrane-bound monoclonal IgM in patients with active disease. The number of fluorescent spots, their size and brightness varied greatly from cell to cell in marrow and blood samples of a given patient, and this finding is in contrast to the homogeneous fluorescent pattern observed in chronic lymphocytic leukemia. The data suggest that macroglobulinemia represents the proliferation of a clone of B cells which continues to mature and differentiate.
Comparison of oestradiol and prostaglandin E2 vaginal gel for ripening the unfavourable cervix
Authors: G. J. Lewis
Journal: BMJ (1981)

I was surprised that Mr. Philip M. Tromans and others (February 28 p. 679) neglected to discuss the relatively high cesarean section rates (23% and 27%) in the groups of patients they studied.  Recently at St. Marys Hospital Manchester the effects of a (PG) prostaglandin vaginal pessary (3 mg PGE2 in a Witepsol base) or an intracervical extraamniotic Foleys catheter on cervical ripening prior to induction were studied prospectively in 66 patients.  Although both methods significantly improved the modified Bishop score and decreased the length of subsequent labor compared with the controls the cesarean section rates were similar in all groups (PGE2 group--27%; Foleys catheter group--32%; control group--27%).  In our study 68% of patients delivered by cesarean section had cephalopelvic disproportion.  The possibility of cephalopelvic disproportion should therefore be considered in women admitted for induction of labor with an unripe cervix.  (Full Text)
LICHEN PLANUS: FAILURE TO CULTIVATE VIRUSES OR MYCOPLASMA
Authors: LIONEL FRY, MICHAEL WITHERS
Journal: British Journal of Dermatology (1968)

Journal Article LICHEN PLANUS: FAILURE TO CULTIVATE VIRUSES OR MYCOPLASMA Get access LIONEL FRY, LIONEL FRY Department of Dermatology, The London Hospital and Department of Bacteriology, The London Hospital Medical College Search for other works by this author on: Oxford Academic Google Scholar MICHAEL WITHERS MICHAEL WITHERS Department of Dermatology, The London Hospital and Department of Bacteriology, The London Hospital Medical College Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 80, Issue 6, 1 June 1968, Pages 384–386, https://doi.org/10.1111/j.1365-2133.1968.tb12324.x Published: 01 June 1968 Article history Accepted: 23 January 1968 Published: 01 June 1968
Endoscopic Signs in Celiac Disease: Reply
Authors: A. Tursi
Journal: Endoscopy (2003)

I am grateful to Dr. Brocchi and colleagues for their interest in our article and for their comments. They offer several constructive points for discussion. With regard to the issue of the classification of endoscopic signs, I think that it is necessary to clarify a few points. First of all, I agree with Brocchi and colleagues that histological damage usually occurs in advance of the macroscopic appearance of damage. In fact, we showed that a normal appearance of the second part of the duodenum may also conceal slight histological damage (Table 1 in [1]). Secondly, there are no existing classifications of endoscopic lesions in celiac disease. Before carrying out our study, we noted in our clinical practice that in patients with celiac disease, there was a certain correlation between the endoscopic appearance of the duodenum and histological damage. As the duodenal folds decreased and the appearance of the mucosa deteriorated, we observed a progressive worsening of the histological damage. We therefore conducted the study with arbitrary assessment of the grading of the increasing duodenal endoscopic damage, from a normal appearance of the duodenum to an absence of duodenal folds, with or without a “mosaic” or “micronodular” appearance of the mucosa. With regard to the sign defined as “granular mucosa” in the second part of the duodenum, this is an endoscopic sign that has not been reported in the published literature [2] [3] [4], in which duodenal mucosa shows a “granular” appearance, with normal presence of duodenal folds. This sign is very different from the sign defined as “micronodular mucosa”, in which it is clearly observed that the duodenal mucosa mimics submucosal nodules (see Figure 1 in [1]), as clearly described recently by Brocchi et al. [2]. In our experience, “granular mucosa” is an endoscopic feature which, although strictly related to several small-bowel diseases (such as celiac disease, Crohn's disease, and Giardia lamblia infestation), is more prevalent in celiac disease, just as “scalloping” of the duodenal folds is more prevalent in celiac disease, although it is not a specific marker of the disease [5].
Underdiagnosis and undertreatment of asthma in childhood
Authors: M H Verdier-Taillefer, J F Tessier, B Doyon, J Lellouch
Journal: BMJ (1983)

pines, which raise seizure thresholds and reduce seizure durations; the use of minimal currents with unknown consequences to seizure pattern and duration; and the failure to monitor seizures, both to describe the electro- graphic durations and patterns and to assure us that an effective fit did, indeed, occur.The last factor is particularly important.In their survey of British practice, Pippard and Ellam15 found that even sophisticated observers could misjudge seizure duration and decide that a short fit was "effective," when it was not.The controversy about seizures and currents will continue until seizure durations and seizure patterns are monitored objectively and researchers determine the parameters of the fit that have the highest correlation with anti- depressant efficacy.A change of focus is needed-from the electric current (and, in the United States, the electrode location) to the biochemical, neurohumoral, and electro- graphic factors in the fit which accompany and which facilitate clinical change.
Syringe and Needle Exchange to Prevent HIV Infection-Reply
Authors: John K. Watters
Journal: JAMA (1994)

<h3>In Reply.</h3> —In our article in<i>JAMA</i>we concluded that needle sharing (a term Dr Fernando dislikes) is perpetuated by laws that restrict access to and possession of needles and syringes. We disagree with Fernando's assertion that NEPs undermine progress toward the needed deregulation of injection equipment. Needle-exchange programs have led directly to the relaxation and/or repeal of antiparaphernalia laws in Connecticut, Hawaii, Maryland, Massachusetts, and throughout Australia. Consequently, we think the successful demonstration of syringe exchange will continue to help, not impede, modification of these laws. We likewise question the veracity of Fernando's claim that outreach efforts involving bleach distribution for needle disinfection have already interfered with such progress. Needle exchange, like all health promotion technologies, has limitations and we addressed some of these in our article. Despite these limitations, in our study NEP use was a robust predictor of not sharing needles, and this effect increased with the
Signalling through neutrophil Fc gamma RIII, Fc gamma RII, and CD59 is not impaired in active rheumatoid arthritis.
Authors: J Jones, I Laffafian, T Lawson, B D Williams, B P Morgan
Journal: Annals of the Rheumatic Diseases (1996)

To compare neutrophil Fc receptor (Fc gamma R) and CD59 signalling responses in normal healthy subjects and patients with active rheumatoid arthritis (RA).Intracellular free calcium concentrations were measured in neutrophils loaded with the fluorescent calcium indicator fura-2, using a spectrofluorimeter.Basal intracellular calcium ion concentrations were similar in both groups when no primary antibody, CD59, or CD32 (Fc gamma RIII) antibody was added. When CD16 (Fc gamma RIII) antibody was added, there was a significantly greater basal calcium concentration in the patient group compared with the control group. Transient cytosolic calcium ion fluxes were observed after binding Fc gamma RII, Fc gamma RIII, or CD59 with specific monoclonal antibodies and cross linking with the F(ab)2 fragment of sheep antimouse IgG. Peak concentrations of intracellular free calcium, [Ca2+]i, after cross linking each of the three receptors, were comparable between normal healthy donors and patients with RA. The lag period between addition of cross linking antibodies and the increase in calcium was also similar between normal individuals and patients.Contrary to previous reports, these results demonstrate that Ca2+ signalling responses of cross linked Fc receptors in blood neutrophils from patients with RA are identical to those in neutrophils of normal subjects. Signalling responses of cross linked CD59 are also unaltered.
Blood pressure and endocrine responses to changes in dietary sodium intake in cardiac transplant recipients. Implications for the control of sodium balance.
Authors: D R Singer, N D Markandu, M G Buckley, M A Miller, G A Sagnella, D R Lachno, F P Cappuccio, A Murday, M H Yacoub, G A MacGregor
Journal: Circulation (1994)

BACKGROUND The role of cardiac extrinsic innervation in the regulation of sodium balance and blood pressure is controversial. METHODS AND RESULTS We performed a double-blind study of endocrine and blood pressure responses to 5 days of low- (LS, 10 mmol/d) and 5 days of high- (350 mmol/d) sodium intake in 12 cardiac transplant recipients, 12 matched healthy subjects, and 12 matched subjects with untreated essential hypertension. In transplant recipients on low sodium, supine blood pressure was 137/94 +/- 8/4 (mean +/- SEM) mm Hg and plasma atrial natriuretic peptide (ANP) was 59.3 +/- 6.3 pg/mL; on high sodium, blood pressure was 148/97 +/- 5/3 mmHg (P &lt; .05 for systolic pressure versus LS), and ANP was 94.3 +/- 10.6 pg/mL (P &lt; .01 versus LS), respectively. Plasma ANP for those on each diet was significantly higher in the cardiac transplant recipients than in healthy or hypertensive controls; relative changes in plasma ANP in changing from low- to high-sodium diet were similar in each group. Urinary sodium excretion by the fifth day of each diet was similar in each group. Suppression of plasma renin activity and aldosterone by high-sodium diet was blunted in cardiac transplant recipients compared with healthy subjects (respectively, plasma renin activity: 1.41 +/- 0.30 versus 0.68 +/- 0.21 ng.mL-1 x h-1, P &lt; .05; aldosterone: 391 +/- 35 versus 166 +/- 21 pmol/L, P &lt; .05). CONCLUSIONS These results suggest that extensive denervation of the heart does not result in major abnormalities in regulation of large changes in sodium intake and that intact cardiac innervation is not required for plasma ANP responses to altered sodium intake. Blood pressure after cardiac transplantation is sensitive to reduced sodium intake.
IM-13 * MOLECULAR ENGINEERING OF AMPLIFIED TUMOR RNA-PULSED DENDRITIC CELLS IN ADOPTIVE CELLULAR THERAPY TARGETING MEDULLOBLASTOMA AND GLIOBLASTOMA
Authors: O. Yegorov, J. Drake, D. Mitchell
Journal: Neuro-Oncology (2015)

BACKGROUND: Adoptive cellular therapy using transfer of tumor-specific lymphocytes has emerged as a potent strategy for treatment of advanced and refractory malignancies. We have employed the use of total tumor RNA (TTRNA)-pulsed DCs in the ex vivo expansion of tumor-specific lymphocytes for use in adoptive cellular therapy targeting pediatric and adult malignant brain tumors. METHODS: Total tumor RNA was extracted and amplified from resected brain tumor specimens using previously published methods. Efforts to improve recovery, fidelity of amplification, and integrity of RNA included comparative analysis of phenol-free extraction methods, SMARTTM-based cDNA synthesis, RT and PCR primer modifications. To characterize whole pool of cDNA libraries and their IVT RNA products obtained from tumor brain tissues we used next generation sequencing approach. DC generation and T cell expansion under varying culture conditions and cytokine milieus were evaluated to improve functional yields of autologous cellular products. RESULTS AND CONCLUSIONS: We have optimized high quality (RNA integrity, RIN ≥ 8) TTRNA amplification from resected brain tumor specimens using as little as 1 ng of input TTRNA through incorporation of solid-phase paramagnetic bead technology for cDNA synthesis and optimized PCR conditions. Massively parallel RNA sequencing analysis of TTRNA amplified from brain tumor specimens using in-house development of a complete system for cDNA amplification show similar or even better results compared to commercial available Clontech's SMARTer kit. RNA-Seq analysis detected the higher number of transcripts in brain tumor tissues compared to normal brain. We found that TTRNA transfection up-regulates the expression of CD80, CD83, CD86, HLA-DR in mature DCs. We have recently demonstrated the safety and feasibility of this adoptive cellular therapy platform in a phase I trial of pediatric patients with relapsed medulloblastoma and PNETs in a single institutional setting. A multi-institutional phase 2 clinical trial is underway.