tbuckley/cabot-search huggingface dataset:
Prolonged Weakness and Vecuronium
Authors: Dana Bernstein
Journal: Annals of Internal Medicine (1993)

Letters1 April 1993Prolonged Weakness and VecuroniumDana Bernstein, MDDana Bernstein, MDSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-118-7-199304010-00017 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:The recent article by Kupfer and colleagues [1] describes prolonged weakness in 5 of 10 patients who received long-term therapy with vecuronium. In none of these cases, however, was the dose of vecuronium given in mg/kg per day. Four of the ten patients received average doses between 6.7 and 12 mg/hunusually high doses.Metabolites of vecuronium may play a role in prolonged paralysis. The metabolite 3-desacetylvecuronium has neuromuscular blocking activity in feline models [2]. Segredo and colleagues [3] showed an association between high levels of this metabolite and prolonged paralysis. In their study, patients without prolonged paralysis ...References1. Kupfer Y, Namba T, Kaldawi E, Tessler S. Prolonged weakness after long-term infusion of vecuronium bromide. Ann Intern Med. 1992; 117:484-6. Google Scholar2. Bencini AF, Houwertjes MC, Agoston S. Effects of hepatic uptake of vecuronium bromide and its putative metabolites on the neuromuscular blocking actions in the cat. Br J Anaesth. 1985; 57:789-95. Google Scholar3. Segredo V, Caldwell JE, Matthay MA, Sharma ML, Gruenke LD, Miller RD. Persistent paralysis in critically ill patients after long-term administration of vecuronium. N Engl J Med. 1992; 327:524-8. Google Scholar Author, Article, and Disclosure InformationAuthors: Dana Bernstein, MD PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byDiseases of the Peripheral Nervous SystemElectrodiagnostic Studies of the Neuromuscular Respiratory System 1 April 1993Volume 118, Issue 7Page: 569-571KeywordsMetabolitesNeuromuscular blockadeParalysis ePublished: 15 August 2000 Issue Published: 1 April 1993 Copyright & PermissionsCopyright © 1993 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Allergy to Tobacco: An Occupational Hazard
Authors: Gerald J. Gleich, Patrick W. Welsh, John W. Yunginger, Robert E. Hyatt, John B. Catlett
Journal: New England Journal of Medicine (1980)

In the past many investigators suggested that allergic reactions to tobacco antigens might be responsible for the occurrence of disease.1 The evidence linking disease with allergy to tobacco antigens was based on positive skin tests in patients with the disease. More recently, Becker and his associates2 , 3 have revived the concept that sensitivity to antigens present in tobacco may cause allergic reactions in human beings.We describe a patient who experienced rhinitis and asthma while working in a cigarette factory and who was sensitive to allergens in tobacco leaf. This allergy is a hazard of employment in the tobacco manufacturing industry. . . .
Bronchoscopy under General Anaesthesia and its Application: (A cuffed bronchoscopy in an emergency, haemorrhage in particular)
Authors: S. Hanzawa, S. Horie, H. Katsuki
Journal: Endoscopy (1974)

Since 1957, a newly designed and developed cuffed bronchoscope with general anaesthesia has been used for the examination and treatment of over 2,500 patients at our institute. The examination of bronchoscopy under general anaesthesia is carried out using rigid bronchofiberscopes and flexible bronchofiberscopes through a cuffed straight tracheal tube. Through this tube, bronchial brushing, punch biopsy and transbronchial needle biopsy can be done in combination with routine observation. As a rule, the clinical diagnosis and indication of operation are determined in reference to the findings of bronchial epithelium as well as the results of cytological and histological examinations of brushing smear or punch biopsy. On the other hand, in the curative aspect, not only the securing of the airway under direct view even through active bleeding in bronchial lumen, but also sucking in the bronchial lumen or inflating the lung, can be performed easily and accurately during the operation or in an emergency through this bronchoscope. So, it seems that the ultimate value of this method cannot be evaluated. To further emphasize the usefulness of the cuffed bronchoscope, the author reports the details of several significant cases in the institute's experience, including a case which developed an intrabronchial bleeding and was successfully treated using this method, thus saving the patient's life.
Survivin promotes cell proliferation in human hepatocellular carcinoma
Authors: Takeshi Ito, Katsuya Shiraki, Kazushi Sugimoto, Takenari Yamanaka, Katsuhiko Fujikawa, Masaaki Ito, Koujiro Takase, Masami Moriyama, Hirokazu Kawano, Midori Hayashida, Takeshi Nakano, Atsushi Suzuki
Journal: Hepatology (2000)

Survivin is a recently described inhibitor of apoptosis. Because suppression of apoptosis is important for carcinogenesis and tumor growth, we investigated the expression and function of survivin in human hepatocellular carcinomas (HCCs). We have shown that 4 HCC cell lines and 7 out of 8 human HCC tissues expressed survivin messenger RNA (mRNA), whereas expression of survivin mRNA was not detected in normal liver and nontumor areas of these tissues using the reverse transcription polymerase chain reaction. Survivin was detected primarily in the nucleus by immunofluorescence staining of HCC cells. In addition, 14 of 20 (70%) HCC tissues showed positive nuclear staining for survivin, whereas nontumor tissues showed little detectable staining by immunohistochemistry. Survivin expression strongly correlated with the proliferation index but not significantly with the apoptosis index in HCC tissues. Therefore, we performed cell cycle analysis after survivin transfection and showed that overexpression of survivin resulted in a decrease in the G 0 /G 1 phase and an increase in the S phase in all 4 HCC cell lines. Furthermore, we have found that survivin interacted with cyclin-dependent kinase 4 (Cdk4) and overexpression of survivin released p21 WAF1/Cip1 (p21) from Cdk4. From these results, we conclude that survivin promotes cell proliferation by interacting with Cdk4 and releasing p21 from Cdk4. This may play an important role in carcinogenesis and progression of human HCCs.
Learning from a crisis
Authors: J. G. Merino
Journal: BMJ (2013)

Famines induced by war and economic and social crises are humanitarian tragedies. But they are also “tragic experiments” that shed light on the health effects of food deprivation. Studies of adults born of mothers who were pregnant during the Dutch Hunger Winter at the end of the second world war and of the Chinese famine of 1959-61, for example, contributed to our understanding of the effect of in utero deprivation on adult physical and mental health.

In this week’s issue, Manuel Franco from the Johns Hopkins Bloomberg School of Public Health and colleagues from Cienfuegos in Cuba and Alcala de Henares in Spain report an unfortunate “30-year …
Pulmonary Hypertension Predicts Mortality and Morbidity in Patients with Dilated Cardiomyopathy
Authors: Sandra V. Abramson, James F. Burke, John J. Kelly, James G. Kitchen, Michael J. Dougherty, Donald F. Yih, Frank C. McGeehin, John W. Shuck, Thomas P. Phiambolis
Journal: Annals of Internal Medicine (1992)

▪ Objective: To ascertain whether pulmonary hypertension, as assessed noninvasively by continuous-wave Doppler of tricuspid regurgitation, can be an important independent factor in the prognosis of patients with ischemic or idiopathic dilated cardiomyopathy. ▪ Design: Cohort study of consecutive patients with dilated cardiomyopathy in whom follow-up was obtained on all survivors for 28 months. ▪ Setting: Outpatient cardiology private practice office in a tertiary care center. ▪ Patients: Consecutive sample of 108 patients who presented for a scheduled office visit during a 15-month period. ▪ Measurements: M-mode, two-dimensional, and Doppler echocardiographic examinations were done on all patients at entry into the study and on survivors 1 year later. All examinations included extensive pulsed- and continuous-wave Doppler evaluation for tricuspid regurgitation. ▪ Main Outcome Measures: Overall mortality, mortality due to myocardial failure, and hospitalization for congestive heart failure. ▪ Results: Twenty-eight patients had a high velocity of tricuspid regurgitation (> 2.5 m/s), and 80 patients had a low velocity (≤ 2.5 m/s). After 28 months of follow-up, the mortality rate was 57% in patients with a high velocity compared with 17% in patients with a low velocity (difference of 40%, 95% Cl, 20% to 60%). Hospitalization for congestive heart failure occurred in 75% and 26% of patients, respectively (difference of 49%, Cl, 30% to 68%). Eighty-nine percent of patients with a high velocity either died or were hospitalized compared with only 32% of patients with a low velocity (difference of 57%, Cl, 42% to 72%). The peak velocity of tricuspid regurgitation was the only prognostic variable selected using stepwise logistic regression models for the three outcome events. ▪ Conclusion: Noninvasive assessment of pulmonary hypertension using continuous-wave Doppler of tricuspid regurgitation can predict morbidity and mortality in patients with ischemic or idiopathic dilated cardiomyopathy.
Genome-wide association study identifies a susceptibility locus for thyrotoxic periodic paralysis at 17q24.3
Authors: Ching-Lung Cheung, Kam-Shing Lau, Andrew Y Y Ho, Ka-Kui Lee, Sau-Cheung Tiu, Emmy Y F Lau, Jenny Leung, Man-Wo Tsang, Kin-Wah Chan, Chun-Yip Yeung, Yu-Cho Woo, Elaine Y N Cheung, Victor H F Hung, Ho-Kwong Pang, Chi-Sang Hung, Pak-Chung Sham, Annie W C Kung
Journal: Nature Genetics (2012)
THE ROLE OF ANTIBODY, DELAYED HYPERSENSITIVITY, AND INTERFERON PRODUCTION IN RECOVERY OF GUINEA PIGS FROM PRIMARY INFECTION WITH VACCINIA VIRUS
Authors: Robert M. Friedman, Samuel Baron, Charles E. Buckler, Robert I. Steinmuller
Journal: The Journal of Experimental Medicine (1962)

In guinea pigs, methotrexate and x-radiation have been employed to block the development of delayed hypersensitivity and of antibody to vaccinia virus during experimental infection. Animals whose specific responses were blocked by x-radiation and methotrexate recovered from vaccinia virus infection as rapidly as non-treated control animals suggesting that these responses were not essential in recovery of the infected animals. A virus-inhibiting substance with the properties of interferon was present in skin of untreated and methotrexate- and x-radiation-treated animals infected with vaccinia virus.
Improved outcomes in patients with hepatitis C with difficult-to-treat characteristics: Randomized study of higher doses of peginterferon α-2a and ribavirin
Authors: Michael W. Fried, Donald M. Jensen, Maribel Rodriguez‐Torres, Lisa M. Nyberg, Adrian M. Di Bisceglie, Timothy R. Morgan, Paul J. Pockros, Amy Lin, Lisa Cupelli, Frank Duff, Ka Wang, David R. Nelson
Journal: Hepatology (2008)

Treatment response remains suboptimal for many patients with chronic hepatitis C, particularly those with genotype 1 and high levels of viremia. The efficacy of high-dose regimens of peginterferon alfa-2a and ribavirin was compared with conventional dose regimens in patients with features predicting poor treatment responses. Eligible treatment-naïve adults with genotype 1 infection, hepatitis C virus (HCV) RNA >800,000 IU/mL and body weight >85 kg were randomized to double-blind treatment with peginterferon alfa-2a at 180 or 270 microg/week plus ribavirin at 1200 or 1600 mg/day for 48 weeks (four regimens were evaluated). The primary endpoint was viral kinetics during the first 24 weeks of therapy. Among patients receiving peginterferon alfa-2a (270 microg/week) the magnitude of HCV RNA reduction was significantly greater than for patients randomized to the conventional dose of peginterferon alfa-2a (180 microg/week) for the pairwise comparison for ribavirin at 1600 mg/day (P = 0.036) and numerically greater for the pairwise comparison for ribavirin at 1200 mg/day (P = 0.060). Patients randomized to the highest doses of peginterferon alfa-2a (270 microg/week) and ribavirin (1600 mg/day) experienced the numerically highest rates of sustained virologic response (HCV RNA < 50 IU/mL) and the lowest relapse rate (47% and 19%, respectively). The arm with the higher doses of both drugs was less well-tolerated than the other regimens.Higher fixed doses of peginterferon alfa-2a (270 microg/week) and ribavirin (1600 mg/day) may increase sustained virologic response rates compared with lower doses of both drugs in patients with a cluster of difficult-to-treat characteristics.
Palliative Care for Frail Older Adults
Authors: Kenneth S. Boockvar, Diane E. Meier
Journal: JAMA (2006)

Frailty in older adults is increasingly a recognized syndrome of decline, sometimes subtle, in function and health that may be amenable to available approaches to care. Frailty manifests the following core clinical features: loss of strength, weight loss, low levels of activity, poor endurance or fatigue, and slowed performance. The presence of 3 or more of these features is associated with adverse outcomes including falls, new or worsened function impairment, hospitalization, and death. In this article, we use the case of Mrs K to describe the challenges of recognizing frailty in clinical practice, common problems and symptoms that frail older adults experience, and approaches to these issues that clinicians may incorporate into their practices. We discuss the importance of advance care planning, provider-patient communication, and appropriate palliative care and hospice referral for frail older adults. Frailty is associated with symptomatic long-term disease, decline in function, and abbreviated survival. Therefore, when frailty is severe, delivery of palliative care focused on relief of discomfort and enhancement of quality of life is highly appropriate. The application of multidisciplinary, team-based palliative approaches and of up-to-date geriatrics knowledge is beneficial for treating these patients because of the complexity of their coexisting social, psychological, and medical needs.
A new experimental model for measurement of pulmonary arterial haemodynamic variables in conscious rats before and after pulmonary embolism and during general anaesthesia
Authors: G. A J Riegger, P. Hoferer
Journal: Cardiovascular Research (1990)

Journal Article A new experimental model for measurement of pulmonary arterial haemodynamic variables in conscious rats before and after pulmonary embolism and during general anaesthesia Get access Günter A J Riegger, Günter A J Riegger Medizinische Universitätsklinik, Joseph Schneider Strasse 2, D-8700 Würzburg, Federal Republic of Germany Search for other works by this author on: Oxford Academic PubMed Google Scholar Peter Hoferer Peter Hoferer Medizinische Universitätsklinik, Joseph Schneider Strasse 2, D-8700 Würzburg, Federal Republic of Germany Search for other works by this author on: Oxford Academic PubMed Google Scholar Cardiovascular Research, Volume 24, Issue 4, April 1990, Pages 340–344, https://doi.org/10.1093/cvr/24.4.340 Published: 01 April 1990 Article history Received: 06 October 1989 Accepted: 14 December 1989 Published: 01 April 1990
Risk Factors for Prostate Cancer
Authors: Kenneth J. Pienta
Journal: Annals of Internal Medicine (1993)

Purpose: To review the current state of knowledge regarding risk factors for prostate cancer. Data Sources: Analysis of the literature through the use of MEDLINE as well as identification of papers through review of article bibliographies and the authors' personal files. Current data were also extracted from the Surveillance, Epidemiology, and End Results Program (SEER) database. Data Selection: A review of risk factors for the development of prostate cancer. Emphasis was placed on identifying larger, controlled studies. Data Synthesis: The clinical incidence of prostate cancer is increasing. Risk factors for prostate cancer appear to include age, race, positive family history, vasectomy, and dietary fat intake. Conclusions: It appears that prostate cancer results from an interplay between endogenous hormones and environmental influences that include, most prominently, dietary fat.
Actinic damage on the back is significantly determined by <i>MC1R</i> variants and previous sun exposure compared with other body sites in a multivariate analysis
Authors: J. Wendt, S. Rauscher, S. Burgstaller‐Mühlbacher, F. Roka, I. Fae, G. Fischer, H. Pehamberger, I. Okamoto
Journal: British Journal of Dermatology (2014)

Only recently, site-dependent associations of actinic damage with melanoma were identified in our study population.To elucidate the diverse aetiologies for actinic damage at different body sites.We performed multivariate logistic regression analyses to identify independent risk factors for actinic damage on the face, hands and the back in 2112 participants of central European origin.For actinic damage on the face, age was the only risk factor that remained consistently significant in a multivariate analysis, whereas actinic damage on the back was predominantly associated with number of sunburns, freckles in childhood, holiday weeks and male sex. Moreover, we identified a particular significance of MC1R variants and dorsal actinic skin damage.The particular effect of MC1R variants and sun exposure during recreational time on dorsal actinic damage indicates that actinic damage on the back is more informative regarding susceptibility to sunlight and past sun exposure associated with melanoma risk.
Are All Diseases Infectious? Another Look
Authors: Bennett Lorber
Journal: Annals of Internal Medicine (1999)

Currents21 December 1999Are All Diseases Infectious? Another LookBennett Lorber, MDBennett Lorber, MDSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-131-12-199912210-00101 SectionsAboutFull Text ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail Three years ago, I pointed out that a quiet revolution was taking place in our understanding of disease (Ann Intern Med. 1996; 125:844-51). Emerging evidence suggested that transmissible agents caused or contributed to many illnesses that were previously thought to be degenerative, inflammatory, or neoplastic in origin, and I lamented the lack of attention to this important new model for disease. During the past 3 years, more illnesses have been linked to infections, and evolutionary biologists as well as the popular media are paying attention (The Atlantic Monthly. 1999; 283:41-53). In many instances, technological advances, such as polymerase chain reaction ... Author, Article, and Disclosure InformationAffiliations: PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByFocal infection theory: past and presentDiseases with Long-Term Consequences in Search of a Microbial AgentConcluding Perspectives of Sequelae and Long-Term Consequences of Infectious Diseases-What's Next?What's Out There Making Us Sick?Understanding and Managing Periodontal Diseases: A Notable Past, a Promising FutureMedical practice and community health care in the 21st Century: A time of changeOur genes are not our destiny: incorporating molecular medicine into clinical practiceInfectious Agents and CancerFocal infection: new age or ancient history?Examining unmet needs in infectious diseaseNanobacteria: controversial pathogens in nephrolithiasis and polycystic kidney diseaseA link between chronic asthma and chronic infectionEmerging infectious diseases - a therapeutic challenge 21 December 1999Volume 131, Issue 12Page: 989-990KeywordsAntigensAtherosclerosisChlamydiaChlamydia infectionInfectious diseasesMyocardial infarctionPediatric infectionsPneumoniaStreptococcal infectionsUlcers Issue Published: 21 December 1999 CopyrightCopyright © 1999 by American College of Physicians. All Rights Reserved.Loading ...
Case 6-1979
Authors: Richard C. Cabot, Robert E. Scully, James J. Galdabini, Betty U. McNeely, Neil R. Blacklow, Eugene J. Mark
Journal: New England Journal of Medicine (1979)

Presentation of CaseA 60-year-old woman was admitted to the hospital because of respiratory failure.She was well until 10 days earlier, when symptoms of a respiratory-tract infection developed several days after exposure to epiglottitis and tracheitis in her husband; her symptoms included coryza and myalgia. A week before admission a dry cough appeared, and the temperature rose to 38.9°C. A physician prescribed erythromycin; the cough worsened, and dyspnea developed. She entered another hospital, where confusion was noted. An x-ray film of the chest revealed patchy consolidation throughout both lungs, with confluence in the right upper and lower lobes. The . . .
920 STEATOSIS INDUCED PORTAL HYPERTENSION IS ASSOCIATED IN TIME WITH VASCULAR HYPORESPONSIVENESS, CHARACTERISTICS OF HYPERDYNAMIC CIRCULATION AND SIGNS OF COLLATERAL CIRCULATION
Authors: S.F. Francque, S. Wamutu, W. Verlinden, I. Brosius, A. Herman, E. Van Marck, P. Pelckmans, P. Michielsen
Journal: Journal of Hepatology (2008)
Effect of nedocromil sodium on specific mediator- and antigen-induced airway responses in allergic sheep
Authors: William M. Abraham
Journal: Journal of Allergy and Clinical Immunology (1993)

This study evaluated the airway effects of nedocromil sodium in the sheep model of allergic bronchoconstriction. Nedocromil sodium provided statistically significant protection against both reflex- and mediator-induced bronchoconstriction in allergic sheep as assessed by bronchial responses to inhaled bradykinin and platelet-activating factor, respectively. When administered before antigen challenge, nedocromil sodium blocked both the immediate and late asthmatic response and prevented the subsequent increase in airway hyperresponsiveness. The protective effect of nedocromil sodium against the antigen-induced late response was associated with a significant decrease in the number of airway eosinophils measured by bronchoalveolar lavage. Although nedocromil sodium has no direct bronchodilatory activity, it prevented antigen-induced contractions in sheep tracheal smooth muscle in vitro. These results suggest that nedocromil sodium is active in the sheep model of allergic bronchoconstriction and may be useful in the treatment of reversible obstructive airway disease in human beings.
Case of Ulcerated Stomach
Authors: G. Waldron
Journal: BMJ (1849)

I was sent for early in the morning of November 12th, 1848, to visit a Miss E.,37 years of age, of a dark and sallow complexion.I found her labouring under severe anPd violent pains in the epigastrium, accompanied with cramps of the extremities, a sharp and vibrating pulse, of little volume, and the body suffused with cold and clammy perspiration.Being informed that she