QUINIDINE PURPURA: REPORT OF SIX CASES
Authors: R C BISHOP, H H SPENCER, F H BETHELL
Journal: Annals of Internal Medicine (1959)

Article1 May 1959QUINIDINE PURPURA: REPORT OF SIX CASESRONALD C. BISHOP, M.D., F.A.C.P., HERBERT H. SPENCER, M.D., FRANK H. BETHELL, M.D., F.A.C.P.RONALD C. BISHOP, M.D., F.A.C.P.Search for more papers by this author, HERBERT H. SPENCER, M.D.Search for more papers by this author, FRANK H. BETHELL, M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-50-5-1227 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptAlthough Seyderhelm1in 1927, in a very brief clinical discussion, associated thrombocytopenic purpura with quinidine administration, Broch2in 1941 was the first to give a detailed case report of this phenomenon, to speculate as to the mechanism of the thrombocytopenia, and to provide evidence that the thrombocytopenia was indeed due to an idiosyncrasy to quinidine. In the period from 1947 to 1955 numerous single case reports3-23and a report of two cases by Bigelow and Desforges24were published. Gold25also mentioned two cases of thrombocytopenia due to quinidine in a discussion of quinidine therapy. Nudelman et al.5expressed the opinion...Bibliography1. Seyderhelm R: Medizinische Gesellschaft Göttingen, Klin. Wchnschr. 6: 2065, 1927. Google Scholar2. Broch OJ: Thrombopenisk purpura etter kinidin, Nord. med. 10: 1542-1544, 1941. Google Scholar3. Soisalo P: Thrombocytopenic purpura produced by quinidine, Ann. med. int. Fenniae 36: 181-184, 1947. MedlineGoogle Scholar4. BursteinLamberg AJBA: Thrombocytopeni efter kinidinmedikation, Nord. med. 37: 473-476, 1948. MedlineGoogle Scholar5. NudelmanLeffHowe PLILCD: Thrombopenic purpura following quinidine, J. A. M. A. 137: 1219-1220, 1948. CrossrefMedlineGoogle Scholar6. Larimer RC: Thrombocytopenic purpura following quinidine therapy, Canad. M. A. J. 60: 508-510, 1949. MedlineGoogle Scholar7. 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Med. 37: 190-194, 1952. LinkGoogle Scholar15. Akesson S: A case of thrombocytopenia after quinidine treatment, Cardiologia 21: 762-764, 1952. CrossrefMedlineGoogle Scholar16. Larson RK: The mechanism of quinidine purpura, Blood 8: 16-25, 1953. CrossrefMedlineGoogle Scholar17. BoltonYoung FGRV: Observations on cases of thrombocytopenic purpura due to quinine, sulphamezathine and quinidine, J. Clin. Path. 6: 320-323, 1953. CrossrefMedlineGoogle Scholar18. BarkhamTocantins PLM: Observations on the thrombocytopenia due to hypersensitivity to quinidine, Blood 9: 134-143, 1954. CrossrefMedlineGoogle Scholar19. WeisfuseSpearSass LPWM: Quinidine-induced thrombocytopenic purpura. Report of a fourteenth case and review of clinical and experimental studies, Am. J. Med 17: 414-422, 1954. CrossrefMedlineGoogle Scholar20. GittlerKissinLitwins RDMJ: Quinidine-induced thrombocytopenic purpura complicating Dicumarol therapy, Ann. Int. Med. 42: 1118-1122, 1955. LinkGoogle Scholar21. 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Report of four new cases with special observations on patch testing, J. Lab. and Clin. Med. 48: 205-217, 1956. MedlineGoogle Scholar28. BrecherCronkite GEP: Morphology and enumeration of human blood platelets, J. Appl. Physiol. 3: 365-377, 1950. CrossrefMedlineGoogle Scholar29. Macfarlane RG: A simple method for measuring clot-retraction, Lancet 1: 1199-1201, 1939. CrossrefGoogle Scholar30. Bolton FG: Thrombocytopenic purpura due to quinidine. II. Serologic mechanisms, Blood 11: 547-564, 1956. CrossrefMedlineGoogle Scholar31. BourneO'Sullivan SDJ: Fatal thrombocytopenic purpura due to quinidine, Brit. M. J. 1: 1046-1047, 1957. CrossrefMedlineGoogle Scholar32. SpielmannGathofFritzchePfeiffer WAWEF: Über die Bedeutung der serologischen Reaktionen bei allergisch-medikamentös bedingten Thrombopenien, dargestellt an einem Fall von Chinidinpurpura, Acta haemat. 17: 287-304, 1957. CrossrefMedlineGoogle Scholar33. HalbeisenBreckenridge WARL: Quinidine purpura. A case report, J. M. Soc. New Jersey 54: 385-387, 1957. MedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: *Received for publication February 28, 1958.From the Thomas Henry Simpson Memorial Institute for Medical Research and the Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan.Requests for reprints should be addressed to Ronald C. Bishop, M.D., Simpson Memorial Institute, University of Michigan, Ann Arbor, Michigan. 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