A CLINICAL EVALUATION OF COLCHICINE IN THE TREATMENT OF HODGKIN'S DISEASE
Authors: Arthur Grollman, Robert L. Johnson, William W. Regan
Journal: Annals of Internal Medicine (1955)

Article1 January 1955A CLINICAL EVALUATION OF COLCHICINE IN THE TREATMENT OF HODGKIN'S DISEASEARTHUR GROLLMAN, M.D., Ph.D., F.A.C.P., ROBERT L. JOHNSON, M.D., WILLIAM W. REGAN, M.D.ARTHUR GROLLMAN, M.D., Ph.D., F.A.C.P.Search for more papers by this author, ROBERT L. JOHNSON, M.D.Search for more papers by this author, WILLIAM W. REGAN, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-42-1-154 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptAlthough patients with Hodgkin's disease may in many cases be controlled satisfactorily for a number of years by the use of irradiation, nitrogen mustard and triethylene melamine, a state of refractoriness to these agents ultimately ensues. The addition to our therapeutic armamentarium of other agents for the palliative control of this fatal disorder is obviously desirable.The recognition of the radiomimetic potentialities of colchicine led early to its trial in the control of neoplastic processes.1However, the toxicity as well as the ineffectiveness of this drug in the conditions in which it was first tried discouraged its further use, although...Bibliography1. LevineSilver MGB: Mitotic response to colchicine in human cancer, Proc. Soc. Exper. Biol. and Med. 65: 54, 1947. CrossrefMedlineGoogle Scholar2. Grollman A: Pharmacology and therapeutics, 2nd Ed., 1954, Lea & Febiger, Philadelphia. Google Scholar3. LeiterHartwellKlineNadkarniShear JJLIVMJ: Damage induced in sarcoma 37 with chemical agents. IV. Derivatives of colchiceinamide, J. Nat. Cancer Inst. 13: 731, 1952. MedlineGoogle Scholar4. Isch-Wall P: Quatre cas de maladie de Hodgkin traité par la colchicine, Sang 23: 689, 1952. MedlineGoogle Scholar5. BrownHagerGoehausenGrebelSweeneyHellman GOVMCCBWMRH: Remission in Hodgkin's disease following colchicine, desoxycorticosterone and ascorbic acid, J. Lab. and Clin. Med. 36: 803, 1950. MedlineGoogle Scholar6. Streicher E: Toxicity of colchicine, di-isopropylfluorophosphate, Intocostrin and potassium cyanide in mice, Proc. Soc. Exper. Biol. and Med. 76: 536, 1951. CrossrefMedlineGoogle Scholar7. Albahary C: Maladies medicamenteuses, 1954, Masson & Cie, Paris, pp. 402-407. Google Scholar8. MoeschlinMeyerLichtman SHA: Ein neues Colchicumnebenalkaloid (Demecolcin Ciba) als Zytostatikum myeloischer Leukämien, in press. Google Scholar9. LeblondSegal CPG: Action de la colchicine sur la surrenale et les organes lymphatiques, Compt. rend. Soc. de biol. 128: 995, 1938. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: *Received for publication March 13, 1954.From the Department of Experimental Medicine, Southwestern Medical School of the University of Texas, and the Medical Service, 3750th U.S.A.F. Hospital, Sheppard Air Force Base. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byThe Pharmacology and Therapeutic Aspects of ColchicineDie LymphogranulomatoseClinical Management of Hodgkin’s DiseaseCytological and clinical observations during vincaleukoblastine therapy of disseminated cancerCytologie und Klinik der LymphogranulomatoseClinical studies on anticancer agents 1 January 1955Volume 42, Issue 1Page: 154-170KeywordsAdverse reactionsColchicineDrug regulationHodgkin lymphomaMedical servicesPalliative careToxicity ePublished: 1 December 2008 Issue Published: 1 January 1955 PDF downloadLoading ...