THE CONCENTRATION OF ANTIHEMOPHILIC GLOBULIN (AHG) IN PATIENTS WITH CORONARY ARTERY DISEASE
Authors: A A COOPERBERG, J I TEITELBAUM
Journal: Annals of Internal Medicine (1961)

Article1 May 1961THE CONCENTRATION OF ANTIHEMOPHILIC GLOBULIN (AHG) IN PATIENTS WITH CORONARY ARTERY DISEASEARTHUR A. COOPERBERG, M.D., JACOBO I. TEITELBAUM, M.D.ARTHUR A. COOPERBERG, M.D., JACOBO I. TEITELBAUM, M.D.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-54-5-899 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptBlood coagulation bears an important relationship to atherosclerosis, first, because thrombosis is its most serious complication, and second, because one of the current theories of the pathogenesis of atherosclerosis is that the vascular lesions are initiated by mural thrombi. In both, a hypercoagulable state has been implicated as being responsible for the thrombosis.1, 2Because of increasing understanding of the mechanism of blood coagulation, and newer technics, it is now possible to determine quantitatively the concentration of many clotting factors. It is felt that such factors, which are normally concerned with hemostasis, may be important in thrombus formation when present...Bibliography1. GroenVan der Heide JRM: Atherosclerosis and coronary thrombosis. Medicine 38: 1, 1959. CrossrefMedlineGoogle Scholar2. Duguid JB: Diet and coronary disease. Lancet 1: 891, 1954. CrossrefGoogle Scholar3. AlexanderMeyersKennyGoldsteinGurewitchGrinspoon BLJRVL: Blood coagulation in pregnancy. Proconvertin and prothrombin, and the hypercoagulable state. New Engl. J. Med. 254: 358, 1956. CrossrefMedlineGoogle Scholar4. Macfarlane RG: Blood coagulation, with particular reference to the early stages. Physiol. Rev. 36: 479, 1956. CrossrefMedlineGoogle Scholar5. BiggsDouglas RAS: The thromboplastin generation test. J. Clin. Path. 6: 23, 1953. CrossrefMedlineGoogle Scholar6. Quick AJ: The prothrombin in hemophilia and in obstructive jaundice. J. Biol. Chem. 109: 73, 1935. Google Scholar7. CooperbergTeitelbaum AAJI: The concentration of antihaemophilic globulin (AHG) related to age. Brit. J. Haemat. 6: 281, 1960. CrossrefMedlineGoogle Scholar8. SiseKimballAdamis HSDMD: Plasma thromboplastin component (PTC) deficiency produced by prolonged administration of prothrombopenic anticoagulants. Proc. Soc. Exp. Biol. Med. 89: 81, 1955. CrossrefMedlineGoogle Scholar9. DockertFlueckigerMatterKoller FPMF: Clotting factor X. Physiologic and physiochemical properties. Proc. Soc. Exp. Biol. Med. 90: 17, 1955. CrossrefMedlineGoogle Scholar10. BrinkhousPenick KMGD: Some systemic alterations in clotting factors following local tissue injury, in Thrombosis and embolism, Benno Schwabe and Co., 1954, p. 428. Google Scholar11. Snedecor GW: Statistical methods, 5th Ed. Iowa State College Press, 1956. Google Scholar12. Owren PA: Permanent anticoagulant therapy in cardiovascular disease. Northw. Med. 56: 298, 1957. MedlineGoogle Scholar13. Yudkin J: The epidemiology of coronary disease. Progr. Cardiov. Dis. 1: 116, 1958. CrossrefMedlineGoogle Scholar14. BergsagelHougie DEC: Intermediate stages in the formation of blood thromboplastin. Brit. J. Haemat. 2: 113, 1956. CrossrefMedlineGoogle Scholar15. McDonaldEdgill LM: Coagulability of the blood in ischaemic heart disease. Lancet 2: 457, 1957. CrossrefGoogle Scholar16. Mustard JF: Blood coagulation in subjects with and without clinical evidence of atherosclerotic vessel disease. Canad. Med. Ass. J. 79: 554, 1958. MedlineGoogle Scholar17. GertlerGarnBland MMSMEF: Age, serum cholesterol and coronary artery disease. Circulation 2: 517, 1950. CrossrefMedlineGoogle Scholar18. StewartAcheson JWED: Atherosclerosis in haemophiliac. Lancet 1: 1121, 1957. CrossrefGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Montreal, Canada*Received for publication December 21, 1960.From the Department of Medicine and Haematology, Jewish General Hospital, Montreal, Canada.Requests for reprints should be addressed to A. A. Cooperberg, M.D., Jewish General Hospital, 3755 St. Catherine Road, Montreal, Canada.†General Electric Co. 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OWEN JR., M.D.Coagulation Disturbances with Manifest Bleeding in Extrahepatic Portal Hypertension and in Liver CirrhosisOn the nature of hypercoagulabilityBlood Coagulation and Intravascular Thrombosis 1 May 1961Volume 54, Issue 5Page: 899-907KeywordsAtherosclerosisAttentionBlood coagulationHemostasisHospital medicineLesionsPathogenesisStable coronary artery diseaseThrombosisVascular medicine ePublished: 1 December 2008 Issue Published: 1 May 1961 PDF downloadLoading ...