tbuckley/cabot-search huggingface dataset:
Abstract P105: Safety of Beta Blockers in the Acute Management of Cocaine-associated Chest Pain
Authors: Morhaf Ibrahim, Diego Maselli, Housin Merza, Mohammad Manar Abd Alhadi, Zaher Fanari, Yazan Badawi, Andrew Hamilton
Journal: Circulation (2008)

Cocaine is the most abused illegal drug in patients presenting to emergency rooms with chest pain, accounting for almost 40% of all drug related visits. It is not known whether all â Blockers (BB) and α1-Selective agents (α1-BB) or mixed α1/β-adrenergic antagonists (α1/β-BB) are safe in the acute management of cocaine-associated chest pain, due to fears of unopposed alpha-receptor activity resulting in coronary artery spasm and hypertensive urgency. Methods: 378 patients presenting to the emergency rooms (ER) in two different hospitals with chest pain who tested positive for cocaine, were evaluated by retrospective chart review. We reviewed the presence and type of BB used in relation to peak elevation in troponin T and troponin I. Troponin elevation was defined as a troponin I &gt;0.6 and troponin T &gt;0.1 if creatinine was &lt;2 mg/dl. Results: The 378 patients comprised African Americans (77%), Hispanics (11%), Caucasian (9%). Of these 12% had typical chest pain, 22% had history of coronary artery disease, 56% had hypertension, and 21% had diabetes mellitus. The admission EKG showed changes (ST elevation, ST depression or new T wave inversion) in 43%. BBs were used in 43%. Troponin became elevated in 9.9% of all patients. There was no difference in the number of patients with troponin rise in the BB and non-BB groups 21/165 vs 16/213 (p=0.1). There was no difference in mean peak troponin levels in patients with troponin rise who were treated with BB vs. no BB 6.7 vs. 5.7 (p=0.6). There was no difference in mean peak troponin levels in patients with troponin rise who were treated with a β1-BB vs. a α1/β-BB 7.5 vs. 4.1 (p=.4). No cases of hypertensive urgency were identified after taking any BB. Conclusion: Troponin rise is not uncommon in patients with cocaine associated chest pain and occurs in 10%. In patients with cocaine-associated chest pain BBs did not appear to change the incidence of troponin rise. â1 Selective BBs did not appear to worsen troponin levels compared to mixed α1/â-adrenergic antagonists. There were no cases of unopposed alpha activity reported.
Linkage of a familial platelet disorder with a propensity to develop myeloid malignancies to human chromosome 21q22.1-22.2
Authors: CY Ho, B Otterud, RD Legare, T Varvil, R Saxena, DB DeHart, SE Kohler, JC Aster, SB Dowton, FP Li, M Leppert, DG Gilliland
Journal: Blood (1996)
Abstract 19642: Correlation between Diabetes Control and Diastolic Dysfunction
Authors: Roozbeh Sharif, Wissam I Khalife, Mohammad A Morsy, Adnan Khan, Sangeeta Mutnuri, Anjali Kohli
Journal: Circulation (2012)

Background: The association of diabetes mellitus (DM) and left ventricular diastolic dysfunction (DD) has been well established. Objective: We aimed to investigate whether better serum glucose control is associated with lower risk of developing DD in diabetic patients. Methods: In this observational retrospective study, we reviewed the echocardiographic results of patients who presented to ambulatory clinics of a tertiary academic medical center. Study population included 1329 DD patients with LVEF&gt;50% and 308 randomly selected normal controls. Demographic, clinical variables and serum hemoglobin A1c (Hb A1c) level were compared between DD patients and normal controls. The same comparison was conducted between patients with impaired relaxation (grade I) and those with pseudonormal (grade II) or restrictive (grade III). Serum A1c was considered as the surrogate of diabetic control. We used logistic regression analysis to examine the association of DM control with DD and its severity, after adjusting for potential confounders. Results: Overall 51.8% of the participants were females. Among 1329 patients with DD 1238 (93.2%) had grade I and 91 (6.8%) had grade II (or higher). DM was reported in 19% of DD patients and 20.1% of normal controls (p=0.0953). However, serum HbA1c was higher among DD patients, compared to normal controls (7.5 vs. 6.4, p=0.005). Multivariable analysis indicated that after adjusting for age, sex, estimated glomerular filtration rate, and history of hypertension, higher serum HbA1c level is an independent correlate of DD (odds ratio: 1.4, 95%CI: 1.1, 1.7, p=0.006). Furthermore, comparison of DM prevalence and serum HbA1c level between grade I DD patients with grade II (or higher) was not statistically significant. Conclusion: The results of this study demonstrated the possible role of better DM control in prevention of DD in diabetic patients. Further studies are encouraged on potential mechanistic pathway that can alleviate diabetes-induced left ventricle dysfunction.
Abstract 21643: Impaired Functional Sympatholysis in Human Hypertension Is Mediated by Angiotensin II
Authors: Wanpen Vongpatanasin, Zhongyun Wang, Debbie Arbique, Gary Arbique, Beverley Adams-Huet, Jere Mitchell, Ronald G Victor, Gail D Thomas
Journal: Circulation (2010)

In normal physiologic states, sympathetic vasoconstriction is markedly blunted during exercise to optimize blood flow to the working muscle. This protective adaptation known as functional sympathol...
Incidence of Germline Mutations in Cancer-Predisposition Genes in Children with Hematologic Malignancies: a Report from the Pediatric Cancer Genome Project
Authors: Michael Walsh, Gang Wu, Michael Edmonson, Tanja A Gruber, John Easton, Donald Yergeau, Bhavin Vadodaria, Xiaotu Ma, Xiang Chen, Rose McGee, Christine Odom, Sheila A Shurtleff, Matthew Parker, Michael Rusch, Erin Hedlund, Robert Huether, Gordon Lemmon, Joy Nakitandwe, Jared Becksfort, Panduka Nagahawatte, Li Dong, Amanda Larson Gedman, Zachary J Faber, Jinjun Cheng, Jinjun Dang, Ching-Hon Pui, Kim E Nichols, Amar Gajjar, David W Ellison, Alberto Pappo, Charles G. Mullighan, Elaine R Mardis, Richard K Wilson, Jinghui Zhang, James R Downing
Journal: Blood (2014)
Gemcitabine (GEM) + oxaliplatin (OX) in patients (pts) with stage III/IV ovarian cancer following 3 cycles of carboplatin (CB) + paclitaxel (PAC): Preliminary report of a phase II study
Authors: R. Arca, J. Ibarra, G. Lerzo, M. Mandachain, E. Mickievicz, J. Perez, E. Richardet, J. Rodger, M. Van Kooten, M. Orlando
Journal: Journal of Clinical Oncology (2004)

5111 Background: GEM is active in recurrent epithelial ovarian cancer. OX activity in ovarian cancer is similar to cisplatin in first-line therapy and PAC in nonrefractory relapses. This multicenter, prospective phase II study combines GEM/OX as first-line sequential therapy for advanced ovarian cancer in pts after 3 cycles of CB/PAC. Primary endpoint is time to disease progression; secondary endpoints are CA 125 response rate, objective response, response duration, overall survival, correlation between expression of MMR and p53 and efficacy, and toxicity. Methods: Pts with confirmed histologic diagnosis of stage III/IV epithelial ovarian carcinoma, initial surgery including anexohysterectomy + omentectomy, 3 cycles of CB ≥AUC 5 and PAC ≥175 mg/m2, no other prior chemotherapy, and adequate organ and marrow function were enrolled. Three to 4 weeks after CB/PAC, pts received GEM 1000 mg/m2 on days (d) 1,15 (100-minute infusion) and OX 85 mg/m2 on d2,16 (120-minute infusion), q28d. Results: To date, 18 pts (median age 57 [range 42–73]; Zubrod performance status 0/1 [10/8 pts]) have been enrolled. 8 pts had stage IIIB; 7, stage IIIC; 3, stage IV. At baseline, median CA 125 level was 777 ng/ml (range 27–9330). Of 13 evaluable for CA 125 response, 12 had complete response and 1 progressed; 3 were evaluable for objective response (1 complete and 2 partial). Total number GEM/OX cycles was 51 (median 2.83 [range 1–3]). All intended doses given as planned; only 5.8% were delayed due to insufficient hematologic recovery. All were evaluable for toxicity. Grade (G) 3 anemia occurred in 2 cycles (3.9%); G3 neutropenia, in 1 cycle (1.9%); mild thrombocytopenia (G1), in 4 cycles (7.8%). G3 nausea occurred in 1 cycle (1.9%); G3 vomiting, in 2 cycles (3.9%). Reversible G1/2 sensory neuropathy occurred in 9 (17.6%) and 3 cycles (5.9%), respectively. No treatment-related deaths occurred. Conclusions: GEM/OX following CB and PAC is feasible, with minimal and manageable toxicity, in pts with ovarian cancer. Updated results of survival and pharmacology will be presented. Supported by Eli Lilly, Debiopharm. Author Disclosure Employment or Leadership Consultant or Advisory Stock Ownership Honoraria Research Funding Expert Testimony Other Remuneration Eli Lilly
Abstract 810: Impact of Elevated Plasma Matrix Metalloproteinase-2 on Prognosis in Hypertrophic Cardiomyopathy: Evidence from Long-Term Follow-Up of Genotyped Patients
Authors: Eiichi Masuta, Hidekazu Ino, Noboru Fujino, Katsuharu Uchiyama, Kenshi Hayashi, Kenji Sakata, Toshinari Tsubokawa, Yuichiro Sakamoto, Akira Funada, Akihiko Muramoto, Masakazu Yamagishi
Journal: Circulation (2008)

Background: Previous studies suggest that production of matrix metalloproteinase-2 (MMP-2) which is responsible for cardiac remodeling could determine prognosis of hypertrophic cardiomyopahty (HCM). However, few data exist regarding the importance of MMP-2 production in clinical settings. Therefore, we determined MMP-2 levels correlated to prognosis in HCM with sarcomere gene mutations. Methods and Results: Echocardiography and determination of plasma MMP-2 levels by enzyme-linked immunoassay were simultaneously performed in 31 HCM patients (22 women, mean age 56±12 years) with sarcomere protein gene mutation including 22 for cardiac troponin I, 5 for cardiac myosin binding-protein C, 3 for cardiac troponin T and 1 for beta-myosin heavy chain. Major cardiac events such as hospitalization due to congestive heart failure or ventricular fibrillation and mortality were prospectively examined for follow-up period of 48.4±29.1 months. When patients were divided into two groups (Group A: MMP-2 ≥800 ng/ml n=16 and Group B: MMP-2&lt;800ng/ml n=15), there was no differences in mean age (59.4±11.7 year vs 53.1±11.3 year, p=0.13). On echocardiograms, interventricular septal thickness in group A (11.7±4.2 mm) was smaller than that in group B (15.9±4.8 mm, p&lt;0.05) and percent fractional shortening (FS) was significantly impaired in group A (24.8±12.5%) in comparison with that in group B (37.7±8.1%, p=0.002). There was negative correlation between the MMP-2 levels and FS (p&lt;0.001, r=0.76). The frequency of cardiac events was significantly higher in group A (10 patients of 16 patients) than in group B (1 patient of 15 patients, p=0.0012). Importantly, 5 patients of group A died, although none of groupB patients did (p=0.018). Conclusion: These results demonstrate that the high plasma concentration of MMP-2 (≥800 ng/ml) could be a predictor of prognosis in HCM with sarcomere mutations probably through reflecting impaired left ventricular function.
Paradoxical Response to Exercise in Asymptomatic Hypertrophic Cardiomyopathy
Authors: Stéphane Lafitte, Patricia Reant, Cecile Touche, Xavier Pillois, Marina Dijos, Florence Arsac, Jerome Peyrou, Michel Montaudon, Philippe Ritter, Raymond Roudaut, Anthony DeMaria
Journal: Journal of the American College of Cardiology (2013)
Abstract 226: Nurses' Retention of BLS and ACLS Skills Improves Survival from In-Hospital Cardiac Arrest
Authors: Migaku Kikuchi, Hisao Matsushima, Yukiko Tosaki, Ikue Tomizawa, Isao Taguchi, Shichiro Abe, Kazuyuki Ono, Teruo Inoue
Journal: Circulation (2011)

OBJECTIVE: To evaluate whether nurses' retention of BLS and ACLS skills improves survival from in-hospital cardiac arrest (IHCA). METHODS: A prospective interventional cohort study was performed. All of 24 registered nurses in a general ward were assigned to 6 groups after training of BLS and ACLS. At immediately and 9 months after training, the 6 groups were evaluated by skill performance tests based on the American Heart Association 2005 BLS and ACLS tools in simulated environment. Survival from IHCA after resuscitation efforts by nurses as first responders was classified after-training term (2010) and before-training term (2008-2009) and examined the outcome. RESULTS: The evaluation in 9 month after training resulted that core skills of chest compression were well-retained. Delivering 30 compressions and 2 ventilations, pressing first shock button of AED &lt; 90 seconds from AED arrival and management of drug use were also well-retained in 6 groups, whereas both first 2 ventilations with bag-valve-mask were done in only one group. Checking carotid pulse or checking breathing was little done for at least 5 seconds but no more than 10 seconds. As concerns survival from IHCA, 53 patients (67.8 yr, M/F=35/18) received resuscitation efforts by nurses as first responders in 2008-2009, and 6 patients (77.4 yr, M/F=4/2) received resuscitation in ward in 2010. The outcome of in-ward cardiac arrest after training improved significantly compared with that of IHCA before training. The return of spontaneous circulation rate increased from 38% to 83% (P=0.04), 7-day survival increased from 19% to 83% (P=0.003), 30-day survival increased from 15% to 67% (P=0.01), and cerebral performance category 1 at hospital discharge increased from 11% to 50% (P=0.04). CONCLUSIONS: Registered nurses had well retained BLS and ACLS skills for 9 months. The nurses' retention of those skills improved survival from IHCA. Contrary to other skills, the skills of assessment for breathing and circulation were little retained. This assessment may not affect on the outcome, and thus, our results may support validity that “look, listen and feel for breathing” was removed from assessment step of the 2010 algorithm, as well as that “A-B-C” changed to “C-A-B”.
Gastric (and Salivary) Excretion of Radioiodine in Man (Preliminary Report)&lt;xref ref-type="fn" rid="fn1"&gt;&lt;sup&gt;1&lt;/sup&gt;&lt;/xref&gt;
Authors: Schiff L, Stevens Cd
Journal: JNCI Journal of the National Cancer Institute (1947)

Journal Article Gastric (and Salivary) Excretion of Radioiodine in Man (Preliminary Report) Get access Leon Schiff, M. D., Leon Schiff, M. D. Department of Internal Medicine, College of Medicine, University of Cincinnati, and the Gastric Laboratory, of the Cincinnati General Hospital2 Search for other works by this author on: Oxford Academic PubMed Google Scholar C. D. Stevens, Ph. D., C. D. Stevens, Ph. D. Department of Internal Medicine, College of Medicine, University of Cincinnati, and the Gastric Laboratory, of the Cincinnati General Hospital2 Search for other works by this author on: Oxford Academic PubMed Google Scholar W. E. Molle, M. D., W. E. Molle, M. D. Department of Internal Medicine, College of Medicine, University of Cincinnati, and the Gastric Laboratory, of the Cincinnati General Hospital2 Search for other works by this author on: Oxford Academic PubMed Google Scholar H. Steinberg, M. D., H. Steinberg, M. D. Department of Internal Medicine, College of Medicine, University of Cincinnati, and the Gastric Laboratory, of the Cincinnati General Hospital2 Search for other works by this author on: Oxford Academic PubMed Google Scholar Carl W. Kumpe, M. D., Carl W. Kumpe, M. D. Department of Internal Medicine, College of Medicine, University of Cincinnati, and the Gastric Laboratory, of the Cincinnati General Hospital2 Search for other works by this author on: Oxford Academic PubMed Google Scholar P. Stewart P. Stewart Department of Internal Medicine, College of Medicine, University of Cincinnati, and the Gastric Laboratory, of the Cincinnati General Hospital2 Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 7, Issue 5, April 1947, Pages 349–354, https://doi.org/10.1093/jnci/7.5.349 Published: 01 April 1947
Abstract 3219: Influence of Adiposity on Arterial Stiffness in Healthy Children
Authors: Satoru Sakuragi, Katrina Abhayaratna, Christine O’Reilly, Wichat Srikusalanukul, Karen Gravenmaker, Marc Budge, Richard Telford, Walter P Abhayaratna
Journal: Circulation (2008)

Childhood obesity is increasingly prevalent in the community and is related to adverse cardiovascular outcomes during adulthood. Identification of intermediary markers of preclinical cardiovascular disease may identify high-risk children who would benefit greatest from primary prevention measures. In this study, we evaluated the relationship between adiposity on arterial stiffness in healthy children. In 596 healthy children (mean age 10.1 +/− 0.3 years; 51% boys), we measured body mass index (BMI) and waist circumference (WC). Percentage body fat (%BF) was quantitated by dual-energy x-ray absorptiometry (DEXA). Insulin resistance was assessed by a fasting insulin level and homeostasis model assessment as an index of insulin (HOMA-IR). Carotid-femoral pulse wave velocity (PWV), an index of aortic stiffness, was estimated by applanation tonometry. Compared to girls, boys were older (10.1 vs 10.0 years, p=0.01); and had higher WC (61 vs. 60 cm, p=0.02), lower %BF (24% vs. 29 %, p&lt;0.001), similar BMI (18.0 vs. 18.5, p=0.05) and lower PWV (4.4 vs 4.5 m/sec, p&lt;0.001). In univariate analysis, BMI (ρ=0.26 and ρ=0.31), WC (ρ=0.32 and ρ=0.26) and %BF (ρ=0.23 and ρ=0.30) were correlated positively with PWV in boys and girls, respectively (all p&lt;0.001). After adjustment for age, systolic blood pressure, mean arterial pressure and heart rate, BMI, WC and %BF were significantly associated with PWV (p&lt;0.01) (Table ). HOMA-IR and fasting insulin level were not predictors of PWV (p&gt;0.07 for both). Increased adiposity is related to arterial stiffness in healthy children, independently of blood pressure and heart rate. Further studies are required to evaluate whether public health efforts to promote healthy lifestyles and weight loss in children will reduce arterial stiffness, attenuate the progression of subclinical cardiovascular disease, and prevent the development of subsequent cardiovascular events in the community. Table: Separate Multivariable Models relating Predictor Variable to PWV
Abstract 18624: Evidence from an Integrated Analysis Combining Genomics, Transcriptomics, and Lipidomics Implies a Causal Role of Inflammation for Low HDL-C
Authors: Pirkka-Pekka Laurila, Ida Surakka, Antti-Pekka Sarin, Jing Tang, Jussi Naukkarinen, Sanni Söderlund, Christian Ehnholm, Terho Lehtimäki, Johan Eriksson, Veikko Salomaa, Antti Jula, Olli Raitakari, Marjo-Riitta Järvelin, Aarno Palotie, Matej Oresic, Matti Jauhiainen, Marja-Riitta Taskinen, Samuli Ripatti
Journal: Circulation (2012)

Low HDL-C is a major risk factor for CVD. To elucidate potential novel pathways behind low HDL-C, we have employed 3 different omics: genomics, transcriptomics, and lipidomics. We performed GWAS on 450 Finns with low or high HDL-C (90th percentiles). Out of 54 individuals, we obtained subcutaneous (SC) fat biopsies for transcriptome analysis, and isolated plasma HDL particles for lipidomics analysis with MS technology. We first conducted gene network analysis for loci associated with low HDL-C observing that SNPs within 4 inflammatory pathways (e.g. antigen-presentation) were enriched among the low HDL-C associated genes (p=10^-5). Also, these inflammatory pathways were over-expressed in SC fat of low-HDL-subjects (p=10^-10). We then calculated genetic risk scores based on low HDL-C associating SNPs from these pathways, observing that high risk score resulted in both decreased HDL-C-levels and increased expression of these inflammatory pathways. Moreover, individual genes of these pathways (e.g. HLA-DRB1 [p=10^-7, TAP2 p=10^-6) exhibited cis-eQTLs, their expression inversely correlating with HDL-C. Consistent with this, the inflammatory nature of the HDL particle of low HDL-C subjects was further highlighted by the elevation of proinflammatory ceramides and reduction of anti-oxidative plasmalogens in the lipidomic analysis, which was also genetic risk score dependent. In a replication analysis of 5 Finnish population cohorts (n=11,211) the low HDL-C associated SNPs were not associated with HDL-C as quantitative trait, but only after using 75, 90, and 95 percentiles as low/high HDL-C criteria. Interestingly, the effect sizes of individual SNPs became stronger when more extreme phenotype criteria for low HDL-C were implemented (e.g. HLA-DRB1; OR for low HDL-C 75 % = 1.11, OR for 90 % = 1.38, OR for 95 % = 1.77). Our findings imply that genetic variation influences inflammatory processes associated with low HDL-cholesterol on both expression and metabolite levels, suggesting more inflammatory and less vasoprotective role for HDL particles in low-HDL-subjects. Using the extreme phenotype approach, we also demonstrate the presence of ‘low HDL genes’ in addition to the population GWAS identified ‘HDL genes.’
Abstract 17678: The Correlation Between Collagen Degradation and LV Function Following Induction of Beta-Blocker Therapy
Authors: Chikako Yoshida, Shinichi Hirotani, Akiko Goda, Mitsuru Masaki, Misato Otsuka, Ayumi Nakaboh, Akiyo Eguchi, Masaaki Lee-Kawabata, Takeshi Tsujino, Tohru Masuyama
Journal: Circulation (2011)

Objectives: Beta-blocker therapy inhibits LV remodeling, and improves not only LV systolic function but also LV diastolic function, and improves prognosis of heart failure patients. But it is unknown why beta-blocker therapy improves LV function. Recently, serum collagen markers such as Procollagen type I C-terminal propeptide (PICP) and collagen type I C-terminal telopeptide (CITP), are useful as index of myocardium collagen synthesis and degradation. We investigate correlation between collagen turnover and LV function following induction of beta-blocker therapy with systolic heart failure patients. Methods: Study population consisted of 46 patients with systolic heart failure. Patients were clinically stable within 1 month and on stable medical therapy, including ACEI or ARB and diuretics, and no beta-blocker therapy. We started beta-blocker therapy, initiated at a target dose of from 5 to 10mg/day. Echocardiography was performed before, 2, 6, and 12 months after the initiation of beta-blocker therapy. LV systolic function was estimated using the LV ejection fraction by Simpson biplane method. Peak systolic strain in the radial direction was measured at the anterior and posterior walls in the short-axis view. We measured E- and A-wave peak velocities and deceleration time (DcT) form the mitral inflow profile, and tissue Doppler early diastolic mitral annular velocity (E'). Serum PICP and CITP were determined. Results (table): A total of 46 patients were enrolled. The median age of all patients was 56±14 years. 15 patients were women and 31 patients were men. EF, DcT and E' were improved after induction of beta-blocker therapy. PICP was not changed, but CITP was decreased from 8.9±7.8 to 6.1±1.7ng/ml at 12 months after treatment. The lower %changes in CITP was associated with the higher %changes in DcT (r=0.21, p&lt;0.05), EF (r=0.29, p&lt;0.01) and radial systolic strain (r=0.26, p&lt;0.05), but not E'. The %changes in PICP were not related %changes in DcT and E'. Conclusions: The improvement in LV systolic function as indexes in EF and radial systolic strain and LV diastolic stiffness as indexes in DcT, correlated with inhibition of collagen degradation in patients with LV systolic function.