tbuckley/cabot-search huggingface dataset:
GP who ran out of hours service provided inadequate care, tribunal hears
Authors: C. Dyer
Journal: BMJ (2013)

A GP earning £230 000 (€270 000; $350 000) a year was 225 km away at his home in Norfolk when he should have been on call in Croydon in south London, the Medical Practitioners Tribunal Service has been told.

Ravi Sondhi, 52, is also accused of abusing his position as financial director of Croydon Doctors on Call (Croydoc) and taking unauthorised financial advances from the service without the board’s agreement.

A fitness to practise panel at the tribunal in Manchester heard that he took the advances for himself and his wife, Salma Uddin, who also worked for the service, …
TCT-839 Early Changes Of Left Ventricle Deformation Indices After Transcatheter Aortic Valve Implantation. A Speckle Tracking Echocardiographic Study
Authors: Manolis Vavuranakis, Konstantinos Kalogeras, Ioannis Vlasseros, Maria Kariori, Dimitrios Vrachatis, Carmen Moldovan, Vicky Katsi, Stylianos Veioglanis, Ioannis Kallikazaros, Christodoulos Stefanadis
Journal: Journal of the American College of Cardiology (2012)
David G. Cogan, MD
Authors: Carl Kupfer
Journal: JAMA (1994)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Evaluation of Decision Rules for Referring Women for Bone Densitometry by Dual-Energy X-ray Absorptiometry
Authors: Suzanne M. Cadarette
Journal: JAMA (2001)

Identification of women with low bone mineral density (BMD) is an important strategy in reducing the incidence of osteoporotic fractures. However, screening all women is not recommended.To assess the diagnostic properties of 4 decision rules--Simple Calculated Osteoporosis Risk Estimation (SCORE), Osteoporosis Risk Assessment Instrument (ORAI), Age, Body Size, No Estrogen (ABONE), and body weight less than 70 kg (weight criterion)--for selecting women for dual-energy x-ray absorptiometry (DXA) testing and to compare results with recommendations made in the National Osteoporosis Foundation (NOF) practice guidelines.Analysis of data from the Canadian Multicentre Osteoporosis Study, a population-based community sample, collected from 9 study centers across Canada between February 1996 and September 1997.Postmenopausal women aged 45 years or older (N = 2365) without bone disease who had DXA data for the femoral neck, data to apply selection criteria, and who were not currently taking estrogens or who had been taking hormone replacement therapy for 5 or more years.Sensitivity, specificity, and area under the receiver operating characteristic (AUROC) curve of each of the 4 decision rules and the NOF guidelines for identifying women with a BMD T score of less than -1.0 SD, less than -2.0 SD, and no more than -2.5 SD at the femoral neck, and percentages of women recommended for testing, stratified by BMD level and age.The percent of women with a BMD T score less than -1, less than -2, and no more than -2.5 were 68.3%, 25.4%, and 10.0%, respectively. The AUROC curves were greatest using SCORE and ORAI. The sensitivity for identifying women with a BMD T score of less than -2.0 was 93.7% (95% confidence interval [CI], 91.8%-95.6%) using the NOF guidelines and was 97.5% (95% CI, 96.3%-98.8%), 94.2% (95% CI, 92.3%-96.1%), 79.1% (95% CI, 75.9%-82.3%), and 79.6% (95% CI, 76.4%-82.8%), respectively, using the SCORE, ORAI, ABONE, and weight criterion. However, the NOF guidelines also resulted in 74.4% (95% CI, 71.3%-77.6%) of women with a normal BMD (T score of -1.0 or higher) being tested compared with 69.2% (95% CI, 65.9%-72.5%), 56.3% (95% CI, 52.7%-59.8%), 35.8% (95% CI, 32.4%-39.2%), and 38.1% (95% CI, 34.6%-41.6%), respectively, using the 4 decision rules. Assessments suggest that ABONE and weight criterion are not useful case-finding approaches.The SCORE and ORAI decision rules are better than the NOF guidelines at targeting BMD testing in high-risk patients. The acceptability of these rules in clinical practice merits further investigation given their potential effect on the use of densitometry services.
Replacement of Scar with Hair-Bearing Scalp
Authors: Edgar M. Holmes
Journal: New England Journal of Medicine (1954)

A PERSON with areas of absent hair attracts attention and is likely to become self-conscious and most anxious to have the deformity improved or, if possible, eliminated. If the area of absent hair is extensive such as that encountered when the entire scalp is lost, it is necessary to wear a wig or transformation to establish a hairy cover. If the patient is fortunate enough to have retained a large part of his hair, it is possible to transfer the hair-bearing scalp to the nonhair-bearing area in such a way that the defect becomes less conspicuous.The skin of the . . .
Treatment-Associated Suicidal Ideation and Adverse Effects in an Open, Multicenter Trial of Fluoxetine for Major Depressive Episodes
Authors: Roy H. Perlis, Charles M. Beasley Jr., James D. Wines Jr., Roy N. Tamura, Cristina Cusin, Deborah Shear, Jay Amsterdam, Frederick Quitkin, Robert E. Strong, Jerrold F. Rosenbaum, Maurizio Fava
Journal: Psychotherapy and Psychosomatics (2006)

&lt;i&gt;Background:&lt;/i&gt; Some reports suggest that a subset of depressed patients may experience suicidality – that is increase or emergence of suicidal ideation (SI) or behavior – after initiation of an antidepressant. The time course and clinical correlates of this phenomenon have not been characterized in detail. &lt;i&gt;Method:&lt;/i&gt; We conducted a secondary analysis of a multicenter, prospective, open, 12-week trial of fluoxetine 20 mg in outpatients with nonpsychotic major depressive episodes. Adverse effects and other clinical features associated with the emergence of suicidality, defined using item 3 of the Hamilton Depression Rating Scale, were examined using Cox regression models. &lt;i&gt;Results:&lt;/i&gt; Among 414 subjects without SI at baseline, 59 (14.3%) reported SI on at least 1 postbaseline visit. In a Cox regression, emergence of activation and worsening of depression severity were independently associated with emergence of SI, along with female gender, younger age and having thoughts that life was not worth living prior to treatment. Treatment response and remission were significantly less likely among subjects who developed SI. &lt;i&gt;Conclusions:&lt;/i&gt; New SI was relatively common in this trial of fluoxetine and associated with the emergence of activation and overall symptomatic worsening. Whether prophylaxis against or aggressive treatment of adverse events can decrease emergence of SI merits further study.
Long-Term Follow-up of Survival in Hodgkin's Lymphoma
Authors: George P. Canellos, Donna Niedzwiecki, Jeffrey L. Johnson
Journal: New England Journal of Medicine (2009)

To the Editor: In 1992, the Cancer and Leukemia Group B (CALGB) reported the results of a prospective three-group randomized trial involving 359 patients with Hodgkin's lymphoma.This trial
Persistent polyclonal B-cell lymphocytosis: extensively proliferated CD27+IgM+IgD+ memory B cells with a distinctive immunophenotype
Authors: M A Berkowska, C Grosserichter-Wagener, H J Adriaansen, D de Ridder, K P Mirani-Oostdijk, H J Agteresch, S Böttcher, A Orfao, J J M van Dongen, M C van Zelm
Journal: Leukemia (2014)
Previous tumour as a predictor of risk of developing lung cancer
Authors: E. M Toloza
Journal: Thorax (2007)

The prognostic ability of a patient’s history of a previous malignant tumour to predict the risk of developing lung cancer

An estimated 174 470 new cases of lung cancer will be diagnosed and 162 460 patients with lung cancer will die in the USA in 2006.1 Worldwide, a more staggering 1 352 132 new cases of lung cancer were diagnosed and 1 178 918 patients with lung cancer died in 2002.2 A low overall 5 year survival of 15–21% has been observed for all clinical stages combined due to findings of localised (or stage I or II) lung cancers in only 16–42% of all new cases of lung cancer.3

In order to improve survival among new cases of lung cancer, several efforts are being made to identify more patients with lung cancer while in the earlier stages (ie, small primary tumours with no mediastinal or distant metastasis) by both clinical and radiographic means. The use of chest radiograpphy with or without sputum cytology and the use of CT scans as screening tests for lung cancer have been evaluated. Five randomised controlled trials suggested that neither chest radiography nor sputum cytology prolonged life expectancies of individuals found to have lung cancer, despite detection of more cancers and more early stage cancers in the “screened” group than in the control group. However, this apparent lack of benefit from screening with chest radiography or sputum cytology has been criticised for the lack of a “no-screening” study arm in the randomised controlled trials or for being powered to detect a 50% reduction in lung cancer mortality in the screened group compared with the control group rather than a smaller but still clinically meaningful 10% reduction in mortality.4

Eight observational studies of low-resolution CT scanning with volunteer cohorts have shown that …
Churg–Strauss syndrome
Authors: R.A. SCHWARTZ, J. CHURG
Journal: British Journal of Dermatology (1992)

Journal Article Churg–Strauss syndrome Get access R.A. SCHWARTZ, R.A. SCHWARTZ Departments of Dermatology Professor R.A. Schwartz, Department of Dermatology, New Jersey Medical School, 185 South Orange Avenue, Newark, NJ 07103‐2714. U.S.A. Search for other works by this author on: Oxford Academic Google Scholar J. CHURG J. CHURG Pathology, New Jersey Medical School, Newark, New Jersey, U.S.A. Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 127, Issue 3, 1 September 1992, Pages 199–204, https://doi.org/10.1111/j.1365-2133.1992.tb00114.x Published: 01 September 1992
Phase 1 study of weekly dosing with the investigational oral proteasome inhibitor ixazomib in relapsed/refractory multiple myeloma
Authors: Shaji K. Kumar, William I. Bensinger, Todd M. Zimmerman, Craig B. Reeder, James R. Berenson, Deborah Berg, Ai-Min Hui, Neeraj Gupta, Alessandra Di Bacco, Jiang Yu, Yaping Shou, Ruben Niesvizky
Journal: Blood (2014)
On the possible relationship between staphylococcal superantigens and increased Vbeta5.1 usage in cutaneous T-cell lymphoma: reply from authors
Authors: T. Linnemann, S. Gellrich, A. Lukowsky, A. Mielke, H. Audring, W. Sterry, P. Walden
Journal: British Journal of Dermatology (2005)

Journal Article On the possible relationship between staphylococcal superantigens and increased Vβ5·1 usage in cutaneous T‐cell lymphoma: reply from authors Get access T. Linnemann, T. Linnemann Department of Dermatology, Venereology and Allergy, Charité– University Medicine Berlin, D‐10098 Berlin, Germany E‐mail: peter.walden@charite.de Search for other works by this author on: Oxford Academic Google Scholar S. Gellrich, S. Gellrich Department of Dermatology, Venereology and Allergy, Charité– University Medicine Berlin, D‐10098 Berlin, Germany E‐mail: peter.walden@charite.de Search for other works by this author on: Oxford Academic Google Scholar A. Lukowsky, A. Lukowsky Department of Dermatology, Venereology and Allergy, Charité– University Medicine Berlin, D‐10098 Berlin, Germany E‐mail: peter.walden@charite.de Search for other works by this author on: Oxford Academic Google Scholar A. Mielke, A. Mielke Department of Dermatology, Venereology and Allergy, Charité– University Medicine Berlin, D‐10098 Berlin, Germany E‐mail: peter.walden@charite.de Search for other works by this author on: Oxford Academic Google Scholar H. Audring, H. Audring Department of Dermatology, Venereology and Allergy, Charité– University Medicine Berlin, D‐10098 Berlin, Germany E‐mail: peter.walden@charite.de Search for other works by this author on: Oxford Academic Google Scholar W. Sterry, W. Sterry Department of Dermatology, Venereology and Allergy, Charité– University Medicine Berlin, D‐10098 Berlin, Germany E‐mail: peter.walden@charite.de Search for other works by this author on: Oxford Academic Google Scholar P. Walden P. Walden Department of Dermatology, Venereology and Allergy, Charité– University Medicine Berlin, D‐10098 Berlin, Germany E‐mail: peter.walden@charite.de Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 152, Issue 4, 1 April 2005, Page 827, https://doi.org/10.1111/j.1365-2133.2005.06523.x Published: 01 April 2005
Proteasome-Dependent Degradation of Guanosine 5′-Triphosphate Cyclohydrolase I Causes Tetrahydrobiopterin Deficiency in Diabetes Mellitus
Authors: Jian Xu, Yong Wu, Ping Song, Miao Zhang, Shuangxi Wang, Ming-Hui Zou
Journal: Circulation (2007)

Tetrahydrobiopterin (BH4) deficiency is reported to uncouple the enzymatic activity of endothelial nitric oxide synthase in diabetes mellitus. The mechanism by which diabetes actually leads to BH4 deficiency remains elusive. Here, we demonstrate that diabetes reduced BH4 by increasing 26S proteasome-dependent degradation of guanosine 5'-triphosphate cyclohydrolase I (GTPCH), a rate-limiting enzyme in the synthesis of BH4, in parallel with increased formation of both superoxide and peroxynitrite (ONOO-).Exposure of human umbilical vein endothelial cells to high glucose concentrations (30 mmol/L D-glucose) but not to high osmotic conditions (25 mmol/L L-glucose plus 5 mmol/L D-glucose) significantly lowered the levels of both GTPCH protein and BH4. In addition, high glucose increased both the 26S proteasome activity and the ubiquitination of GTPCH. Inhibition of the 26S proteasome with either MG132 or PR-11 prevented the high glucose-triggered reduction of GTPCH and BH4. Exposure of human umbilical vein endothelial cells to exogenous ONOO- increased proteasome activity and 3-nitrotyrosine in 26S proteasome. Furthermore, adenoviral overexpression of superoxide dismutase and inhibition of endothelial nitric oxide synthase with N(G)-nitro-L-arginine methyl ester significantly attenuated the high glucose-induced activation of 26S proteasome and the reduction of GTPCH. Finally, administration of MG132 or a superoxide dismutase mimetic, tempol, reversed the diabetes mellitus-induced reduction of GTPCH and BH4 and endothelial dysfunction in streptozotocin-induced diabetes mellitus.We conclude that diabetes mellitus triggers BH4 deficiency by increasing proteasome-dependent degradation of GTPCH.
PET/CT Study Performed After an Oral Administration of 18F-Fluoride
Authors: Samara Riguete Zacchi, Agnes Araújo Valadares, Paulo Schiavom Duarte, Marcelo Tatit Sapienza, Carlos Alberto Buchpiguel
Journal: Clinical Nuclear Medicine (2013)

A 52-year-old woman with right breast cancer was referred for 18F-fluoride whole-body PET/CT for the assessment of bone metastases. The peripheral i.v. access was not obtained after multiple attempts. The radiopharmaceutical was administered by oral route.
John Anthony Morgan
Authors: T. Batchelor, M. Yeatman, M. Hetzel
Journal: BMJ (2009)

John Anthony Morgan (“Tony”) grew up around Cardigan Bay in South Wales before becoming a scholar at Epsom College in Surrey. His love of organ recital music took him to Cambridge University, where he was Duckworth Exhibitioner of Jesus College. He also found time to study medicine and did his clinical undergraduate training at Guy’s in London. After his graduation in 1971, he trained in general and cardiothoracic surgery in London but moved to Groote Schuur Hospital in Cape Town in 1976. It …
Selection of Casualties for Treatment After Nuclear Attack
Authors: Christine K. Cassel
Journal: JAMA (1989)

In the early 1980s the Federal Emergency Management Agency (FEMA) promulgated Civil Defense plans for nuclear war based on relocation of targeted populations to "host areas" where they could live until the dust settled. The plan was so poorly conceived and, indeed, so absurd as to prompt local antinuclear groups throughout the country to create satires such as a booklet published by New York City Physicians for Social Responsibility entitled<i>A New Yorker's Guide to Civil Defense</i>, which included reminders to bring credit cards and have your mail forwarded. These spoofs were not only comical, but very effective in convincing city and town governments to refuse to participate in FEMA planning for nuclear war. The cover of the British Medical Association publication<i>Selection of Casualties for Treatment after Nuclear Attack</i>has the appearance of a similar spoof on post—nuclear war planning. It pictures the earth, as seen from space, with
And Leave for the Unknown
Authors: John Romano
Journal: JAMA (1964)

WE HAVE LEARNED that human behavior is neither completely learned nor is it preformed, to be revealed during maturation. Accumulated evidence suggests that human growth and behavior develop according to a plan. Initially, this concept of epigenesis stemmed from observations in embryology during the 18th century, and maintained that there is progressive formation and differentiation of organs from a homogeneous germ. The theory is used now to help explain growth and development of the mind as well as the body. Scholars in the fields of psychology, psychoanalysis, and the social sciences have evolved interesting and fruitful ideas about the unity of the human life cycle and the specific dynamics of each of its stages as determined by the laws of individual development and social organization. Erik Erikson's theory assumes an inborn coordination to an average expectable environment. His concept of mutuality emphasizes the crucial coordination between the developing individual and
Book: In Our Own Image: Eugenics and the Genetic Modification of People
Authors: A. Paton
Journal: BMJ (2002)

In vitro fertilisation is so widely accepted these days that it is difficult to comprehend the horror and disgust that greeted the first test tube baby in 1978. Yet every subsequent advance in reproductive technology arouses similar passions. For example, many people are apprehensive about the increasing ease with which genetic material in the embryo can be manipulated, with the …
HEREDITARY ATAXIA—FRIEDREICH'S DISEASE.
Authors: DANIEL R. BROWER
Journal: JAMA (1897)

We have before us today, as patients, three members of the same family. In the antecedent history, we can neither see any positive evidence nor gain any information as to venereal disease or alcoholism, two of the most prolific causes of lesions in the nervous system; but we do find a striking record of pulmonary tuberculosis. On the maternal side, two aunts and two uncles, as well as the grandmother, died of this disease. The mother, a French-Canadian, is living and in good health. She is small in stature. On the paternal side there is a history of health and longevity, but we are told that the children were "scrofu- scrofulous." The father, of the same nationality as his wife, died somewhat over a year ago, of organic heart trouble. So far as our uncertain knowledge can testify, the cousins have had no diseases other than those common to childhood.
Stibophen in the Elimination of Worms
Authors: Harry Most
Journal: JAMA (1964)

<h3>To the Editor:—</h3> The potential toxicity of stibophen is well known and all who use it should be aware of the side effects and know which of them are significant. For example, aching of muscles and joints occurs universally not only with stibophen but also with all other antimony drugs administered parenterally. There is no association between these symptoms and clinical or biochemical signs of intoxication, and their occurrence would not justify discontinuance of medication; otherwise no patient would receive a drug in amounts which even approach halfway the desired curative amounts indicated. Cure rates in the range of 96% to 100% are known to occur after the judicious use of adequate amounts of stibophen, antimony and potassium tartrate, and antimony dimercaptosuccinate in<i>Schistosoma haematobium</i>and<i>S mansoni</i>infections. Less effective results are usually associated with intermittent administration of suboptimal doses. Severe toxic reactions, excepting unpredictable hypersensitive-type reactions, usually do
Subacute Thyroiditis: Evolution Depicted by Serial I^131 Scintigram.
Authors: Joel T. Hamburger
Journal: Annals of Internal Medicine (1965)

s1 November 1965Subacute Thyroiditis: Evolution Depicted by Serial I131 Scintigram.Joel T. Hamburger, M.D. (Associate), J. Martin Miller, M.D., F.A.C.P., George Kadian, M.D., Herbert W. Rossin, M.D.Joel T. Hamburger, M.D. (Associate)Search for more papers by this author, J. Martin Miller, M.D., F.A.C.P.Search for more papers by this author, George Kadian, M.D.Search for more papers by this author, Herbert W. Rossin, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-63-5-909_1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptA low radioiodine uptake, with a symmetrical, patchy and irregular distribution of the tracer on scintigram, and a high normal or modestly elevated protein-bound iodine (PBI), have been considered characteristic of subacute thyroiditis. However, this static concept is inadequate to describe the dynamic changes that may be observed in patients with this disorder. The uptake and scintigram pattern observed depend upon the following: (1) The precise point in the evolution of the disease at which the tracer studies are performed; (2) the extent to which the disease involves the parenchyma of the gland; (3) the severity and persistence of the... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Southfield, Michigan PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 November 1965Volume 63, Issue 5Page: 909-909KeywordsProteinsThyroid Issue Published: 1 November 1965 PDF DownloadLoading ...
ABC of diabetes: practical problems.
Authors: P J Watkins
Journal: BMJ (1982)

Employment and hobbiesMost of the problems of diabetics in society result from the ever-present possibility of hypoglycaemia in insulin-treated diabetics.Although this kivpQaIxsgly ni is th IIIoJr hazard is small in many individuals, it is an unacceptable risk in some hozwd.for ov ibr--hd _ circumstances.The guiding principle in making the difficult assessments for employment or hobbies is whether the risk of confusion during hypoglycaemia affects the individual only or whether it also places the safety of others at risk.
EVALUATION OF PULMONARY CAPILLARY WEDGE PRESSURE BY TECHNETIUM-99m BLOOD POOL SCINTIGRAPHY
Authors: T. M. Botemon, R. J. Gray, R. Levy, M. DeRobertis, D. Brown, A. Rozanski, J. Maddahi, H. J.C. Swan, J. Motloff, D. Berman
Journal: Clinical Nuclear Medicine (1982)

Botemon, T. M.; Gray, R. J.; Levy, R.; DeRobertis, M.; Brown, D.; Rozanski, A.; Maddahi, J.; Swan, H. J.C.; Motloff, J.; Berman, D. Author Information