FAILURE OF CORTISONE AND ACTH IN TREATMENT OF THE MORPHINE ABSTINENCE SYNDROME
Authors: H F FRASER, H ISBELL
Journal: Annals of Internal Medicine (1953)

Article1 February 1953FAILURE OF CORTISONE AND ACTH IN TREATMENT OF THE MORPHINE ABSTINENCE SYNDROMEH. F. FRASER, M.D., HARRIS ISBELL, M.D., F.A.C.P.H. F. FRASER, M.D.Search for more papers by this author, HARRIS ISBELL, M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-38-2-234 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptRecently considerable interest has been expressed in the possible ameliorating effects of cortisone and adrenocorticotropic hormone of the anterior pituitary on the symptoms of withdrawal of morphine and related drugs from addicted persons. Rowe1and co-workers have reported that ACTH and cortisone relieved symptoms of abstinence from meperidine (Demerol). Boswell2reported beneficial results with cortisone in combined addiction to meperidine and morphine. Hogness3found that intravenous infusions of ACTH reduced or abolished withdrawal symptoms in 12 of 19 patients presumed to be addicted to heroin. On the other hand, Thorn4and co-workers attempted to withdraw narcotics in one case of...Bibliography1. RoweLambTaylorInsell AGRFBLW: Experience with ACTH and cortisone in private practice, California Med. 75: 11, 1951. MedlineGoogle Scholar2. Boswell WH: Narcotic addiction, U. S. Armed Forces M. J. 2: 1347-1351, 1951. MedlineGoogle Scholar3. Hogness J: Role of ACTH in narcotic addictions, The Armour Laboratories ACTH Conference 2: 480-488 (April) 1952. Google Scholar4. ThornForshamFrawleyHillRocheStraehelinWilson GWPHTFSRMDDL: Usefulness of ACTH and cortisone, New England J. Med. 242: 865-872, 1950. CrossrefMedlineGoogle Scholar5. Himmelsbach CK: Studies of certain addiction characteristics of dihydromorphine, dihydrodesoxymorphine-D, dihydrodesoxycodeine-D, and methyldihydromorphinone, J. Pharmacol. and Exper. Therap. 67: 239, 1939. Google Scholar6. ThornForshamPruntyHills GWPHFTAG: A test for adrenocortical insufficiency, J. A. M. A. 137: 1005, 1948. CrossrefMedlineGoogle Scholar7. Randolph TG: Differentiation and enumeration of eosinophils in the counting chamber with a glycol stain; a valuable technic in appraising ACTH dosage, J. Lab. and Clin. Med. 34: 1696, 1949. Google Scholar8. WinterFlataker CAL: The effect of cortisone, desoxycorticosterone and ACTH upon the responses of animals to analgesic drugs, J. Pharmacol. and Exper. Therap. 101: 93-105, 1951. Google Scholar9. WiklerCarterFraserIsbell ARLHFH: Precipitation of abstinence syndromes by single doses of N-allylnormorphine in addicts, Federation Proc. 11: 402, 1952. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Lexington, Kentucky*Received for publication September 26, 1952.From the National Institute of Mental Health Addiction Research Center, Public Health Service Hospital, Lexington, Kentucky. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byNeuropeptide modulation of opiate and ethanol tolerance and dependenceAssessment of the Abuse Potentiality of Morphinelike Drugs (Methods Used in Man)Corticosteroid HormonesUrinary excretion of hydroxysteroids∗∗According to Weinman and Jayle method in rat urine we found mainly 3 : 21-hydroxysteroids. This agrees with the observation that rat adrenals produce almost entirely corticosterone (Bush; Morris and Williams12)., 17-ketosteroids and aldosterone in rats during a cycle of treatment with morphine 1 February 1953Volume 38, Issue 2Page: 234-238KeywordsAdrenocorticotropic hormoneDrugsHeroinMedical servicesMorphineOpioid addictionPsychiatry and mental health ePublished: 1 December 2008 Issue Published: 1 February 1953 PDF downloadLoading ...