MILIARY TUBERCULOSIS IN A CORTISONE TREATED PATIENT: CASE REPORT WITH AUTOPSY
Authors: R F KLEINSCHMIDT, J M JOHNSTON
Journal: Annals of Internal Medicine (1951)

Case Reports1 September 1951MILIARY TUBERCULOSIS IN A CORTISONE TREATED PATIENT: CASE REPORT WITH AUTOPSYROBERT F. KLEINSCHMIDT, M.D., JOHN M. JOHNSTON, M.D., F.A.C.P.ROBERT F. KLEINSCHMIDT, M.D.Search for more papers by this author, JOHN M. JOHNSTON, M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-35-3-694 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptA case of acute miliary tuberculosis in a patient receiving cortisone for a chronic febrile illness with arthritic manifestations has recently been observed by us. We have not been able to find a similar instance reported in the literature, although active tuberculosis has been enhanced and aggravated by administration of cortisone to experimental animals.Spain and Molomut1produced tuberculosis in guinea pigs and later treated them respectively with cortisone, with streptomycin, and with a combination of cortisone and streptomycin. Autopsy studies showed the lesions in those receiving cortisone to be more extensive, more widely distributed and less well localized than...Bibliography1. SpainMolomut DMN: Effects of cortisone on the development of tuberculous lesions in guinea pigs and on their modification by streptomycin therapy, Am. Rev. Tuberc. 62: 337, 1950. MedlineGoogle Scholar2. HartRees PDRJ: Enhancing effect of cortisone on tuberculosis in the mouse, Lancet 2: 391, 1950. CrossrefMedlineGoogle Scholar3. McNee JW: Cortisone and ACTH: the present position in America, Brit. M. J. 1: 113, 1950. CrossrefMedlineGoogle Scholar4. ThornForshamFrawleyHillRocheStaehelinWilson GWPHTFSRMDDL: The clinical usefulness of ACTH and cortisone, New England J. Med. 242: 783, 1950. CrossrefMedlineGoogle Scholar5. FreemanPershingWangSmith SJCCLC: Effect of ACTH on patients with pulmonary tuberculosis, Proc. of the First Clinical ACTH Conference, Ed. by Mote, J. R., 1950, Blakiston Co., Philadelphia, p. 509. Google Scholar6. TomsettLeMaistreMuschenheimMcDermott RCCW: Effects of ACTH on tuberculosis in humans, Program, 42nd Annual Meeting, Am. Soc. Clin. Investigation, May 1, 1950, p. 59. Google Scholar7. ShickBaggenstossFullerPolley RMAHBFHF: Effects of cortisone and ACTH on periarteritis nodosa and cranial arteritis, Proc. Staff Meet., Mayo Clin. 25: 492, 1950. MedlineGoogle Scholar8. AdlersbergSchaeferDrachman DLSR: Development of hypercholesteremia during cortisone and ACTH therapy, J. A. M. A. 144: 909, 1950. CrossrefMedlineGoogle Scholar9. CosgriffDiefenbachVogt SWAFW: Hypercoagulability of the blood associated with ACTH and cortisone therapy, Am. J. Med. 9: 752, 1950. CrossrefMedlineGoogle Scholar10. SpainMolomutHaber DMNA: Biological studies on cortisone in mice, Science 112: 335, 1950. CrossrefMedlineGoogle Scholar11. HowesPlotzBluntRagan ELCMJWC: Retardation of wound healing by cortisone, Surgery 28: 177, 1950. MedlineGoogle Scholar12. Stoerk HC: Inhibition of the tuberculin reaction by cortisone in vaccinated guinea pigs, Federation Proc. 9: 345, 1950. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: ROBERT F. KLEINSCHMIDT, M.D.; JOHN M. JOHNSTON, M.D., F.A.C.P.Affiliations: Pittsburgh, Pennsylvania*Received for publication March 16, 1951.From the University of Pittsburgh, School of Medicine, and the Department of Medicine, Mercy Hospital, Pittsburgh, Pennsylvania. 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DAVEY, F.A.C.P.COMBINED CORTICOTROPHIN THERAPY AND CHEMOTHERAPY IN PULMONARY TUBERCULOSISTuberculous MeningitisKlinische Beobachtungen bei der Cortison- und ACTH-Behandlung von DermatosenSection of EndocrinologyDeleterious Effect of ACTH and Cortisone on Tuberculosis 1 September 1951Volume 35, Issue 3 Page: 694-702 Keywords Autopsy Guinea pigs Hospital medicine Lesions Miliary tuberculosis Streptomycin ePublished: 1 December 2008 Issue Published: 1 September 1951 PDF downloadLoading ...