tbuckley/cabot-search huggingface dataset:
Abstract 12754: The Association Between Surgical Indications, Operative Risk and Outcome in Infective Endocarditis
Authors: Andrew Wang
Journal: Circulation (2014)

Introduction: The use of surgery in IE relative to indications and operative risk has not been well defined. Objectives: 1) To evaluate the use of surgery in IE as related to indications and operative risk; 2) to analyze the association between surgical indications, operative risk, and 6-month survival. Methods: The International Collaboration on Endocarditis-PLUS is a prospective registry involving 29 centers in 16 countries with 1296 patients with definite left-sided IE. Factors related to surgical decision making and Society of Thoracic Surgery (STS-IE) risk score were evaluated for relationship to surgical treatment and 6-month mortality. Results: Patients had a median age of 62 years (25th, 75th %tile: 47, 72) and a substantial rate of medical comorbidities. A surgical indication was present in 74% of all patients; surgery was performed in 57% of the cohort and 76% of patients with an indication. The most common reason for lack of surgery among patients with a surgical indication was having a poor pr...
ECTODERMAL DYSPLASIAS IN CATTLE.
Authors: VICTOR J. SELMANOWITZ
Journal: British Journal of Dermatology (1971)

Journal Article ECTODERMAL DYSPLASIAS IN CATTLE: ANALOGUES IN MAN Get access VICTOR J. SELMANOWITZ VICTOR J. SELMANOWITZ Dermatologic Research Unit, Orentreich Foundation for the Advancement of Science, 909 Fifth Avenue, New York, N.Y., 10021, U.S.A Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 84, Issue 3, 1 March 1971, Pages 258–265, https://doi.org/10.1111/j.1365-2133.1971.tb14216.x Published: 01 March 1971 Article history Accepted: 29 September 1970 Published: 01 March 1971
FGF7 Supports Hematopoietic Stem and Progenitor Cells and Niche-Dependent Myeloblastoma Cells Via Autocrine Action On Bone Marrow Stromal Cells In Vitro
Authors: Ruri Ishino, Satowa Tanaka, Kaori Minami, Yukiko Ikeuchi, Masaya Yano, Azusa Imanishi, Mami Nagai, Natsumi Hasegawa, Shigetaka Asano, DSci, Mitsuhiro Ito
Journal: Blood (2013)
Variable p‐CREB expression depicts different asthma phenotypes
Authors: G Chiappara, P Chanez, A Bruno, E Pace, F Pompeo, J Bousquet, G Bonsignore, M Gjomarkaj
Journal: Allergy (2007)

Background: Chromatin modification may play a role in inflammatory gene regulation in asthma. Cyclic adenosine mono‐phosphate response element‐binding protein (CREB), with the specific co‐activator, the CREB‐binding protein (CBP), contributes to the acetylation of chromatin and to the transcription of pro‐inflammatory genes. Objectives: To evaluate the expression of CBP and of phospho‐CREB (p‐CREB) in bronchial biopsies and in peripheral blood mononuclear cells (PBMC) of controls (C), untreated (UA), inhaled steroid treated (ICS) and steroid‐dependent asthmatic (SDA) patients. Methods: We used immunohistochemistry in bronchial biopsies and western blot analysis and immunocytochemistry in PBMC. Results: Cyclic adenosine mono‐phosphate response element‐binding protein expression, in the epithelium was similar in all groups, while p‐CREB expression was increased in UA and in SDA in comparison with ICS and C subjects (C vs UA P = 0.002, C vs SDA P = 0.007), (ICS vs SDA P = 0.005), (ICS vs UA P = 0.001). Interestingly, also in the submucosa, p‐CREB was increased in UA and SDA in comparison with ICS and C subjects (C vs UA P = 0.0004) (C vs SDA P &lt; 0.0001) (ICS vs UA P = 0.002) (ICS vs SDA P &lt; 0.0001) and positively correlated with leukocyte infiltration within the bronchi (CD45RB+ cells). Similar results were obtained with PBMC isolated from the same patient groups. Incubation of PBMC in vitro , with fluticasone propionate, decreased the p‐CREB expression induced by cytokine activation (interferon‐γ, tumor necrosis factor‐α). Conclusions: This study demonstrates that the expression of p‐CREB is related, in asthma, to the persistent inflammation according to the disease severity. p‐CREB expression can be modulated by glucocorticoids in responsive patients.
Mutation of the gene encoding the ROR2 tyrosine kinase causes autosomal recessive Robinow syndrome
Authors: Hans van Bokhoven, Jacopo Celli, Hülya Kayserili, Ellen van Beusekom, Sevim Balci, Wim Brussel, Flemming Skovby, Bronwyn Kerr, E. Ferda Percin, Nurten Akarsu, Han G. Brunner
Journal: Nature Genetics (2000)
OP0269 Obesity and the Risk for Development of Rheumatoid Arthritis – Results from a Population-Based Nested Case-Control Study: Table 1.
Authors: L. Ljung, S. Rantapää Dahlqvist
Journal: Annals of the Rheumatic Diseases (2015)

<h3>Background</h3> Studies on obesity and the risk for development of rheumatoid arthritis (RA) have shown diverse results, and studies with prospectively collected data are few. <h3>Objectives</h3> To evaluate the association between obesity and subsequent risk for development of RA. <h3>Methods</h3> In The Västerbotten Interventional Program (VIP) or/and The WHO project Multinational MONItoring of Trends and Determinants of CArdiovascular Disease (MONICA) 1985-2013 individuals with RA (year of onset of symptoms 1989-2013) were identified (cases, n=550), and data from the latest visit antedating onset of RA symptoms were retrieved. From the same population-based, prospective cohorts 1650 controls, matched for age, sex, cohort, inclusion year, cohort and area of inhabitance (rural/urban) were randomly selected. Prospectively collected data on body mass index (BMI; weight/lenght<sup>2</sup>), smoking habits, and educational level was used in calculations of odds ratio; OR (95% confidence interval) in conditional logistical regression assessing associations between obesity and the risk for development of RA. <h3>Results</h3> The cases (mean age at RA symptom onset 58 SD 11 years, 68% women) had been included in the cohorts (MONICA n=49, VIP n=501) at median 6.7 (IQR 6.4) years before the onset of symptoms of RA. Obesity (BMI≥30) was associated with an increased risk for RA development, OR 1.4 (1.1-1.9), compared to those with normal weight (BMI 18.5-25). The association was stronger in male subjects (Table 1). Stratifying the patients on age at onset of symptoms of RA the association between obesity and the risk of RA was only observed in the quartile with earliest disease debut, 32-50 years, OR for obesity vs. normal weight 1.9 (1.1-3.7). <h3>Conclusions</h3> Obesity was independently associated with a modest increase in the risk for subsequent development of RA. This appeared to be relevant mainly for men and patients with RA disease onset at 50 years of age or earlier. <h3>Disclosure of Interest</h3> None declared
A Second and a Third Abnormal Haemoglobin in Norfolk
Authors: R. G. Huntsman, M. Hall, H. Lehmann, P. K. Sukumaran
Journal: BMJ (1963)

MEGALOBLASTIC ANAEMIA~~~~~~~~~~~~~WCLJUM abnormal amounts of formiminoglutamic acid (Figlu).A horizontal type, 1,000-volt electrophoresis instrument was used and a clearly recognizable spot of Figlu on the paper strip (a positive test) has been considered indicative of a deficiency in folic-acid metabolism.The patients studied were 50 cases of megaloblastic anaemia or related conditions.It was found that all of five patients with dietary deficiency of-folic acid, four of six patients with cirrhosis, and three of eight patients with a malabsorption syndrome had positive tests, which were easily reverted by the administration of folic acid.Eleven patients with pernicious anaemia in remission had negative tests, but five out of eight patients with pernicious anaemia in relapse had positive tests.Three of these five patients showed some resistance to folic- acid therapy in reversing the Figlu test to normal.Vitamin B12 alone reverted two of the patients to normal, but in another patient vitamin B12 failed to do this and she required injections of folic acid to achieve it.Other patients tested included cases of erythraemic myelosis and leukaemia with megaloblastic bone- marrow.It is considered that a positive Figlu test may result from dietary insufficiency of folic acid, malabsorption of folic acid, or from metabolic disturbances in the action of folic acid in the body, one important factor in this regard being vitamin B12 metabolism.
Abstract 12288: The Association of Coronary Artery Calcium With Age-related Non-Cardiovascular Disease: The Importance of “Biologic Aging” From the Multi-Ethnic Study of Atherosclerosis (mesa)
Authors: Catherine E Handy, Chintan S Desai, Zeina Dardari, Mouaz H Al-Mallah, Michael Miedema, Pamela Ouyang, Matthew J Budoff, Roger S Blumenthal, Khurram Nasir, Michael J Blaha
Journal: Circulation (2014)

Coronary artery calcium (CAC) can be thought of as a measure of biologic vascular aging, associated with increased risk of cardiovascular and all-cause mortality. We sought to determine if CAC is also associated with non-cardiovascular disease (CVD) events. We included 6,814 participants from MESA, aged 45-84 years, free of CVD and cancer at baseline, followed for a median of 8.5 years. We calculated multivariable-adjusted hazard ratios for new hospital ICD-9 diagnoses of cancer, pneumonia, chronic obstructive pulmonary disease (COPD), chronic kidney disease (CKD), deep vein thrombosis (DVT) or pulmonary embolism (PE), hip fracture and dementia. Analyses were adjusted for age, gender, race, socioeconomic status, BMI, physical activity, diet, tobacco use, number of medications used, systolic and diastolic blood pressure, total and HDL cholesterol, antihypertensive, aspirin and cholesterol medication use and diabetes. Participants with no CAC had absolute event rates of 6.7% for cancer, 3.2% for CKD, 2.8% f...
316. Cystic Fibrosis Airway Epithelial Cells Transfection
Authors: Eric B. Kmiec, Miya Drury
Journal: Molecular Therapy (2004)

The pathway of targeted gene repair may consist of two major steps, the pairing of a short modified single-stranded oligonucleotide with the target site followed by a repair event that reverses a point mutation. In this study, we show that the level of correction is influenced by the position of the mismatched base pair at the target site relative to the oligonucleotide. Vectors were designed to target an eGFP gene containing a single point mutation and integrated stability into DLD-1 cells. 72-mers are introduced into these cells by electroporation and expression of the corrected eGFP mutation is detected by FACS analyses. Oligonucleotides with a number of structural variants were designed to target the mutant eGFP gene. Appreciable levels of gene repair occur when the oligonucleotide contains the base that creates the mismatch with the target site in the center, whereas the efficiency of correction decreases less than two fold when the mismatch is located near the 3′ end of the oligonucleotide. However, correction directed by an oligonucleotide which creates a mismatch near its 5′ end is reduced up to 17 fold, depending on the vector design. The same directionality is observed even when these positioned mismatches are separated by 18 bases of sequence heterology. These results lead us to propose a directional specific repair pathway consisting of proteins involved in both homologous recombination and mismatch repair. Thus, the pairing stability of the repair complex likely plays a role in the successful application of this technique and these types of factors must be taken into consideration when designing protocols for targeted gene repair.
Respiratory Morbidity in Late Preterm Births
Authors: Judith U. Hibbard, Isabelle Wilkins, Liping Sun, Kimberly Gregory, Shoshana Haberman, Matthew Hoffman, Michelle A. Kominiarek, Uma Reddy, Jennifer Bailit, D. Ware Branch, Ronald Burkman, Victor Hugo Gonzalez Quintero, Christos G. Hatjis, Helain Landy, Mildred Ramirez, Paul VanVeldhuisen, James Troendle, Jun Zhang
Journal: JAMA (2010)

Context Late preterm births (34 0 ⁄7-36 6 ⁄7 weeks) account for an increasing proportion of prematurity-associated short-term morbidities, particularly respiratory, that require specialized care and prolonged neonatal hospital stays.Objective To assess short-term respiratory morbidity in late preterm births compared with term births in a contemporary cohort of deliveries in the United States.Design, Setting, and Participants Retrospective collection of electronic data from 12 institutions (19 hospitals) across the United States on 233 844 deliveries between 2002 and 2008.Charts were abstracted for all neonates with respiratory compromise admitted to a neonatal intensive care unit (NICU), and late preterm births were compared with term births in regard to resuscitation, respiratory support, and respiratory diagnoses.A multivariate logistic regression analysis compared infants at each gestational week, controlling for factors that influence respiratory outcomes. Main Outcome MeasuresRespiratory distress syndrome, transient tachypnea of the newborn, pneumonia, respiratory failure, and standard and oscillatory ventilator support. ResultsOf 19 334 late preterm births, 7055 (36.5%) were admitted to a NICU and 2032 had respiratory compromise.Of 165 993 term infants, 11 980 (7.2%) were admitted to a NICU, 1874 with respiratory morbidity.The incidence of respiratory distress syndrome was 10.5% (390/3700) for infants born at 34 weeks' gestation vs 0.3% (140/41 764) at 38 weeks.Similarly, incidence of transient tachypnea of the newborn was 6.4%(n = 236) for those born at 34 weeks vs 0.4% (n=155) at 38 weeks, pneumonia was 1.5% (n=55) vs 0.1% (n=62), and respiratory failure was 1.6% (n = 61) vs 0.2% (n = 63).Standard and oscillatory ventilator support had similar patterns.Odds of respiratory distress syndrome decreased with each advancing week of gestation until 38 weeks compared with 39 to 40 weeks (adjusted odds ratio [OR] at 34 weeks, 40.1; 95% confidence interval [CI], 32.0-50.3and at 38 weeks, 1.1; 95% CI, 0.9-1.4).At 37 weeks, odds of respiratory distress syndrome were greater than at 39 to 40 weeks (adjusted OR, 3.1; 95% CI, 2.5-3.7),but the odds at 38 weeks did not differ from 39 to 40 weeks.Similar patterns were noted for transient tachypnea of the newborn (adjusted OR at 34 weeks, 14.7; 95% CI, 11.7-18.4and at 38 weeks, 1.0; 95% CI, 0.8-1.2),pneumonia (adjusted OR at 34 weeks, 7.6; 95% CI, 5.2-11.2and at 38 weeks, 0.9; 95% CI, 0.6-1.2),and respiratory failure (adjusted OR at 34 weeks, 10.5; 95% CI, 6.9-16.1 and at 38 weeks, 1.4; 95% CI, 1.0-1.9). ConclusionIn a contemporary cohort, late preterm birth, compared with term delivery, was associated with increased risk of respiratory distress syndrome and other respiratory morbidity.
Abstract 15890: The Non-HDL Cholesterol to HDL Cholesterol Ratio is an Independent Predictor for Poor Long-Term Clinical Outcomes in Patients With Target LDL Cholesterol in the Drug Eluting Stent Era
Authors: Jung-Yeon Chin, Ki-Bae Seung, Tae-Hoon Kim, Jeong-Eun Yi, Tae-Seok Kim, Soe Hee Ann, Eun Ho Choo, Yoon-Seok Koh, Hun-Jun Park, Kiyuk Chang, Sang-Hyun Ihm, Jong Min Lee, Wook Sung Chung, Suk Min Seo, Pum Joon Kim
Journal: Circulation (2011)

Introduction: LDL Cholesterol/HDL Cholesterol (LDL-C/HDL-C) ratio and triglyceride/HDL Cholesterol (TG/HDL-C) ratio have been increasingly recognized as stronger prognostic factors of coronary arte...
Abstract 3725: HGF/c-Met axis drives cancer aggressiveness in the neo-adjuvant setting of ovarian cancer
Authors: Marisa Mariani, Mark McHugh, Marco Petrillo, Steven Sieber, Shiquan He, Mirko Andreoli, Paul Fiedler, Giovanni Scambia, Shohreh Shahabi, Cristiano Ferlini
Journal: Cancer Research (2014)

Abstract Background: Ovarian cancer is the most lethal gynecologic malignancy. Recently, NACT has been clinically tested as alternative approach for the management of ovarian cancer patients. A biological predictor helpful in selecting patients for NACT would be desirable. Indeed, chemotherapy has a strong impact in modifying the biology of tumor and rendering it more aggressive. This study was aimed at identifying actionable mechanisms of resistance to NACT. Methods: Expression of a panel of microRNAs was screened in a discovery set of 85 patients. Analysis of the potential targets was conducted in the same RNAs by calculating significant correlations between microRNAs and genes. Quantitative fluorescent immunohistochemistry was employed in a validation set of 109 patients. Pre and post-NACT specimens were analyzed in multiple cores of tumor from formalin fixed paraffin embedded material (FFPE). Results: MiR-193a-5p was significantly overexpressed in the NACT setting. Analysis of its potential targets demonstrated that this microRNA is also significantly correlated with the expression levels of HGF and MET genes. Analysis of protein expression in samples taken before and after NACT demonstrated that both HGF and c-Met are increased after NACT. Patients who relapse shortly after NACT exhibited the highest relative basal expression of both HGF and c-Met, while the opposite phenomenon was observed in the best responders. Conclusion: These findings demonstrate that NACT refractory patients express activation of the HGF/c-Met pathway. HGF/c-Met expression may help select eligible patients for this modality of treatment. Moreover, inhibitors of this pathway may improve the efficacy of NACT. Citation Format: Marisa Mariani, Mark McHugh, Marco Petrillo, Steven Sieber, Shiquan He, Mirko Andreoli, Paul Fiedler, Giovanni Scambia, Shohreh Shahabi, Cristiano Ferlini. HGF/c-Met axis drives cancer aggressiveness in the neo-adjuvant setting of ovarian cancer. [abstract]. In: Proceedings of the 105th Annual Meeting of the American Association for Cancer Research; 2014 Apr 5-9; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2014;74(19 Suppl):Abstract nr 3725. doi:10.1158/1538-7445.AM2014-3725
Abstract 2155: Plasma Adiponectin Levels in Patients with Atrial Fibrillation
Authors: Masayuki Shimano, Rei Shibata, Yukiomi Tsuji, Noriyuki Ouchi, Yasuya Inden, Toyoaki Murohara
Journal: Circulation (2008)

The occurrence and development of atrial fibrillation (AF) are associated with changes in electrical properties and cardiac structure, known as electrical and structural atrial remodeling. AF characterized by atrial remodeling also occurs with obesity-related conditions. Adiponectin, an adipose tissue-derived hormone, exerts beneficial effects on the heart in various pathological conditions. These observations led us to speculate that adiponectin levels affect the development and prevalence of AF. Here, we investigated a potential association between circulating adiponectin levels and atrial remodeling in patients with AF. We measured plasma adiponectin levels, serum carboxy-terminal telopeptide of collagen type I (CITP) levels, as a collagen type I degradation marker, and serum type III procollagen-N-peptide (PIIINP) levels, as a collagen type III synthesis marker in consecutive 414 patients; 225 paroxysmal AF, 81 persistent AF and 108 paroxysmal supra-ventricular tachycardia without AF history (control) patients, who admitted for scheduled radiofrequency catheter ablation. Plasma adiponectin levels were significantly higher in patients with persistent AF compared to paroxysmal AF and control patients (p&lt;0.05). Serum CITP levels, but not serum PIIINP levels, were also higher in patients with persistent AF compared to paroxysmal AF and control patients (p&lt;0.05). In addition, a positive correlation was observed between adiponectin levels and CITP levels (r=0.39, p&lt;0.005) or the P wave duration (r=−0.31, p&lt;0.05) in patients with persistent AF. High plasma adiponectin levels are associated with the presence of persistent AF, which is accompanied by increased CITP levels. Hyperadiponectinemia might also attenuate atrial conduction disturbance. Thus, measurement of plasma adiponectin could be useful for assessment of AF.
Abstract 1661: The pro-inflammatory role of the putative oncogene Bcl-3
Authors: Wanhu Tang, Hongshan Wang, Estefania Claudio, Ulrich Siebenlist
Journal: Cancer Research (2014)

Abstract Bcl-3 is an oncogene first identified by its translocation into the immunoglobulin alpha-locus in some cases of chronic B cell lymphocytic leukemia. Bcl-3 is an atypical member of the IκB family that exhibits unique properties compared with classic IκBs. It readily enters nuclei, where it interacts with p50/NF-κB1 or p52/NF-κB2 homodimers to transcriptional activity. Depending on the cellular context and target gene, Bcl-3 may promote or inhibit gene expression. Recently it was reported that Bcl-3 could promote tumor growth as well as metastasis in several mouse tumor models. Bcl-3 is also known to play important roles in innate and adaptive immunity. For example, mice lacking Bcl-3 become highly susceptible to various pathogens, including T. gondii and K. pneumoniae, but the underlying mechanisms remain poorly understood. In addition, little is known about potential roles of Bcl-3 in inflammation that may contribute to cancers. Here we report that in a mouse model of colitis, which is dependent on the functions of Th1 cells, Bcl-3 had an intrinsic role to maintain Th1 cells and thus promote inflammation over time. This could also be demonstrated in vitro, where Bcl-3 had no effect on differentiation of Th1 cells per se, but was required for their maintenance. We will show how Bcl-3 promoted the maintenance of specifically Th1, but not Th17 cells. We will also provide evidence that Bcl-3 likely mediated these effects via p52/NF-κB2. Our data demonstrate that the oncoprotein Bcl-3 can contribute to chronic inflammatory conditions that in turn may be associated with cancer development. Note: This abstract was not presented at the meeting. Citation Format: Wanhu Tang, Hongshan Wang, Estefania Claudio, Ulrich Siebenlist. The pro-inflammatory role of the putative oncogene Bcl-3. [abstract]. In: Proceedings of the 105th Annual Meeting of the American Association for Cancer Research; 2014 Apr 5-9; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2014;74(19 Suppl):Abstract nr 1661. doi:10.1158/1538-7445.AM2014-1661