JAUNDICE ASSOCIATED WITH THE ADMINISTRATION OF SODIUM P-AMINOSALICYLIC ACID: REVIEW OF THE LITERATURE AND REPORT OF A CASE
Authors: W E BELLAMY, H P MAUCK, G R HENNIGAR, M WIGOD
Journal: Annals of Internal Medicine (1956)

Case Reports1 April 1956JAUNDICE ASSOCIATED WITH THE ADMINISTRATION OF SODIUM P-AMINOSALICYLIC ACID: REVIEW OF THE LITERATURE AND REPORT OF A CASEWILLIAM E. BELLAMY JR., M.D., H. PAGE MAUCK JR., M.D., GORDON R. HENNIGAR, M.D., MILTON WIGODWILLIAM E. BELLAMY JR., M.D.Search for more papers by this author, H. PAGE MAUCK JR., M.D.Search for more papers by this author, GORDON R. HENNIGAR, M.D.Search for more papers by this author, MILTON WIGODSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-44-4-764 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo date there have been 27 reported cases of jaundice attributed to the oral administration of para-aminosalicylic acid (PAS or sodium p-aminosalicylic acid) used in the treatment of tuberculosis.1-13 Of these cases, only four have been reported in the American literature.9, 12, 14 In this entire group of cases only one has come to autopsy, with the pathologic changes in the liver described.12In view of the wide use of this drug at the present time, we feel it worth while to report a case of jaundice developing in a patient with miliary tuberculosis while on PAS therapy. We believe...Bibliography1. Cuthbert J: Acquired idiosyncrasy to Na PAS, Lancet 2: 209, 1950. CrossrefMedlineGoogle Scholar2. ScottMcCann ABJ: Acquired sensitivity to Na PAS, Lancet 2: 366, 1950. CrossrefGoogle Scholar3. LivingstoneStreet REW: Acquired idiosyncrasy to Na-p-aminosalicylic acid, Lancet 2: 308, 1950. Google Scholar4. Hurrell G: Acute toxic jaundice, Brit. M. J. 2: 729, 1950. CrossrefGoogle Scholar5. HeardCampbellHurley KHAHJJ: Hypokalemia complicating Na-PAS therapy for pulmonary tuberculosis, M. J. Australia 2: 606, 1950. CrossrefMedlineGoogle Scholar6. Landsborough D: Hepatitis during PAS therapy, Brit. M. J. 1: 884, 1951. CrossrefGoogle Scholar7. McManisMira AGWJ: Hepatitis following PAS therapy, M. J. Australia 2: 747, 1951. CrossrefMedlineGoogle Scholar8. McKendrick GD: Toxic hepatitis from PAS, Lancet 2: 15, 1951. MedlineGoogle Scholar9. Quarterly Progress Report, U. S. Veterans Administration Hospitals coöperating in study of chemotherapy of tuberculosis: July, 1951. Google Scholar10. Thomas JH: A case of recurrent jaundice, Tubercle 33: 329, 1952. CrossrefMedlineGoogle Scholar11. FergussonMcIntyreGemmell AGJPAR: Toxic hepatitis and PAS, Brit. M. J. 1: 855, 1952. CrossrefMedlineGoogle Scholar12. AllenBeachamKeschner HSEH: Hepatitis and hypokalemia in tuberculosis, Am. Rev. Tuberc. 68: 136, 1953. MedlineGoogle Scholar13. Dixon WM: Toxic reaction to para-amino-salicylic acid, Brit. J. Tuberc. 48: 102, 1954. CrossrefGoogle Scholar14. HayesWeiss RHEM: Hypersensitivity reaction to oral PAS, Dis. of Chest 22: 645, 1953. CrossrefGoogle Scholar15. Randolph BM: Acute miliary tuberculosis of the liver, Am. Rev. Tuberc. 22: 593, 1930. Google Scholar16. CleveGibsonWebb EAJRWM: Atypical tuberculosis of the liver with jaundice, Ann. Int. Med. 41: 251, 1954. LinkGoogle Scholar17. BiehlNimitz JPH: Studies on the use of high dose of isoniazid. I. Toxicity studies, Am. Rev. Tuberc. 70: 430, 1954. MedlineGoogle Scholar18. BarreDanrigal EA: Hepatite epidemique ou hepatite d'inoculation, Presse méd. 61: 68, 1953. Google Scholar19. Brun J: Les icteres au cours du traitement par le PAS et leur pathogenie, Soc. med. d. hôp. de Lyon Bull. 2: Avril 1951. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Richmond, Virginia*Received for publication February 3, 1955.From the Departments of Medicine and Pathology, Medical College of Virginia, Richmond, Virginia. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byExchange Transfusion as Treatment of Acute Hepatic Failure Due to Antituberculosis DrugsRICHARD J. LEDERMAN, M.D., PH.D., FAITH B. DAVIS, M.D., PAUL J. DAVIS, M.D.The General Appearance (Habitus)Serum transaminase levels during treatment with isoniazid, streptomycin and pasBiochemical Studies of Severe Liver Damage Caused by p-Aminosalicylic AcidExperimental Chemotherapy of Tuberculosis and Other Mycobacterial InfectionsAntimicrobial Treatment of Tuberculosis in ChildhoodCase 42-1961Hypersensitivity to para-aminosalicylic acidHepatitis Due to p-Aminosalicylic Acid HypersensitivityDRUG-INDUCED HEPATIC INJURY*HANS POPPER, M.D., F.A.C.P., FENTON SCHAFFNER, M.D., F.A.C.P.Icterus and Febrile Reactions in Response to Isonicotinic Acid HydrazineFatal Subacute Hepatitis Associated With Para-aminosalicylic AcidPresent-day management of tuberculosis 1 April 1956Volume 44, Issue 4Page: 764-772KeywordsDrug therapyHepatitis AIsoniazidLiverMiliary tuberculosisNecrosisOral administrationPeriodic acid SchiffSodiumTuberculosis ePublished: 1 December 2008 Issue Published: 1 April 1956 PDF downloadLoading ...