tbuckley/cabot-search huggingface dataset:
QUININE AND ATEBRINE—A COMPARISON
Authors: Otto T. Brosius
Journal: Annals of Internal Medicine (1938)

Article1 September 1938QUININE AND ATEBRINE—A COMPARISONOTTO T. BROSIUS, M.D., D.T.M. & H., F.A.C.P.OTTO T. BROSIUS, M.D., D.T.M. & H., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-12-3-353 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo be tremendously over-rated when first introduced is quite a characteristic event in the history of all new remedial agents—especially of specifics. Then after the pendulum has swung in the opposite direction through the condemnations of the ultra-conservatives a return towards a correct estimate of the remedial measure may be expected.Practically ever since the historical occasion when a decoction from the bark of a Peruvian tree first effected a spectacular cure in the oft-cited case of Cinchona, the wife of the Spanish Viceroy to Perú, substitutes for this bark and its derivatives have been eagerly sought because of the... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Santa Marta, Colombia, S. A.*Received for publication December 4, 1936. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 September 1938Volume 12, Issue 3Page: 353-364KeywordsQuinineResearch laboratories ePublished: 1 December 2008 Issue Published: 1 September 1938 PDF downloadLoading ...
765. The Efficacy of Adenovirus Vector-Mediated Gene Transfer into Human Osteoblasts In Vitro and Osseous Tissue In Vivo
Authors: Keun Bae Lee, Charles L. Saltzman, Peter Taft, Michael Klotz, Joseph Zabner
Journal: Molecular Therapy (2004)

Adenovirus has been extensively used in experimental and clinical models as a vector for gene therapy and has been used successfully to infect a variety of bone cells. However, gene transfer to osteoblasts in unfractured bone has not been adequately investigated. The purpose of this study is to demonstrate the feasibility and efficacy of adenovirus-mediated gene transfer into bone cells in vitro and in vivo.
The hair dye allergy self-test: considerations for treating physicians
Authors: J.P. Thyssen, I.R. White, C. Lidén, J.D. Johansen
Journal: British Journal of Dermatology (2012)

Journal Article The hair dye allergy self‐test: considerations for treating physicians Get access J.P. Thyssen, J.P. Thyssen National Allergy Research Centre, Department of Dermato‐Allergology, Copenhagen University Hospital Gentofte, Niels Andersens Vej 65, DK‐2900 Hellerup, Denmark Search for other works by this author on: Oxford Academic Google Scholar I.R. White, I.R. White Department of Cutaneous Allergy, St John’s Institute of Dermatology, London SE1 7EH, U.K Search for other works by this author on: Oxford Academic Google Scholar C. Lidén, C. Lidén Institute of Environmental Medicine, Karolinska Institutet, SE‐171 77 Stockholm, Sweden E‐mail: jacob.p.thyssen@regionh.dk Search for other works by this author on: Oxford Academic Google Scholar J.D. Johansen J.D. Johansen National Allergy Research Centre, Department of Dermato‐Allergology, Copenhagen University Hospital Gentofte, Niels Andersens Vej 65, DK‐2900 Hellerup, Denmark Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 168, Issue 2, 1 February 2013, Page 448, https://doi.org/10.1111/j.1365-2133.2012.11163.x Published: 01 February 2013
Infused autograft lymphocyte-to-monocyte ratio and survival in T-cell lymphoma post-autologous peripheral blood hematopoietic stem cell transplantation
Authors: Luis F. Porrata, David J. Inwards, Stephen M. Ansell, Ivana N. Micallef, Patrick B. Johnston, William J. Hogan, Svetomir N. Markovic
Journal: Journal of Hematology & Oncology (2015)

The infused autograft lymphocyte-to-monocyte ratio (A-LMR) is a prognostic factor for survival in B-cell lymphomas post-autologous peripheral hematopoietic stem cell transplantation (APHSCT). Thus, we set out to investigate if the A-LMR is also a prognostic factor for survival post-APHSCT in T-cell lymphomas.From 1998 to 2014, 109 T-cell lymphoma patients that underwent APHSCT were studied. Receiver operating characteristic (ROC) and area under the curve (AUC) were used to identify the optimal cut-off value of A-LMR for survival analysis and k-fold cross-validation model to validate the A-LMR cut-off value. Univariate and multivariate Cox proportional hazard models were used to assess the prognostic discriminator power of A-LMR.ROC and AUC identified an A-LMR ≥ 1 as the best cut-off value and was validated by k-fold cross-validation. Multivariate analysis showed A-LMR to be an independent prognostic factor for overall survival (OS) and progression-free survival (PFS). Patients with an A-LMR ≥ 1.0 experienced a superior OS and PFS versus patients with an A-LMR < 1.0 [median OS was not reached vs 17.9 months, 5-year OS rates of 87% (95% confidence interval (CI), 75-94%) vs 26% (95% CI, 13-42%), p < 0.0001; median PFS was not reached vs 11.9 months, 5-year PFS rates of 72% (95% CI, 58-83%) vs 16% (95% CI, 6-32%), p < 0.0001].A-LMR is also a prognostic factor for clinical outcomes in patients with T-cell lymphomas undergoing APHSCT.
Pouring fuel on the fire: Th17 cells, the environment, and autoimmunity
Authors: Patrick R. Burkett, Gerd Meyer zu Horste, Vijay K. Kuchroo
Journal: Journal of Clinical Investigation (2015)

Cytokines play a critical role in controlling the differentiation of CD4 Th cells into distinct subsets, including IL-17-producing Th17 cells. Unfortunately, the incidence of a number of autoimmune diseases, particularly those in which the IL-23/IL-17 axis has been implicated, has risen in the last several decades, suggesting that environmental factors can promote autoimmunity. Here we review the role of cytokines in Th17 differentiation, particularly the role of IL-23 in promoting the differentiation of a pathogenic subset of Th17 cells that potently induce autoimmune tissue inflammation. Moreover, we highlight emerging data that indicate that environmental factors, including the intestinal microbiota and changes in diet, can alter normal cytokine regulation with potent effects on Th17 differentiation and thus promote autoimmunity, which has strong implications for human disease.
Non-Development of Eosinophilia in Pernicious Anemia Patients Treated With Desiccated Stomach
Authors: S. M. Goldhamer
Journal: Annals of Internal Medicine (1931)

Article1 March 1931Non-Development of Eosinophilia in Pernicious Anemia Patients Treated With Desiccated StomachS. M. GOLDHAMER, M. D.S. M. GOLDHAMER, M. D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-4-9-1105 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe possibility of producing remissions in pernicious anemia under controlled conditions by the use of liver, liver extracts or stomach has opened the way for the careful study of the changes in the blood as the condition improves. The present paper deals with the changes in the eosinophile content of the blood. Minot and Murphy1noted that after a liver diet the polymorphonuclear eosinophile leucocytes occasionally increased to 20% or more, the rise persisting for many weeks. Whitby2reported an eosinophilia in four patients treated with raw or cooked liver. He felt that there was a relationship between the reticulocyte...Bibliography1 MINOTMURPHY GRWP: "A Diet Rich in Liver in the Treatment of Pernicious Anemia," J. A. M. A., September, 1927, 89, 759. CrossrefGoogle Scholar2 WHITBY LE: "Leucocytic Changes Resulting from the Treatment of Pernicious Anemia with Liver," Lancet, February, 1928, 1, 285. CrossrefGoogle Scholar3 SMITHSHIRLEYWHITBY KLE: "Blood Changes Associated with Liver Diet in Young Convalescents," Lancet, August, 1928, 2, 277. CrossrefGoogle Scholar4 ORDWAYGORHAM TLW: "The Treatment of Pernicious Anemia with Liver and Liver Extract," J. A. M. A., September, 1928, 91, 925. CrossrefGoogle Scholar5 WATKINSBERGLUND CHH: "Analysis of Morphological Blood Changes in Pernicious Anemia Following Administration of Liver," Proc. Soc. for Exp. Biology and Medicine, December, 1927, 25, 206. CrossrefGoogle Scholar6 MEULENGRACHTHOLM ES: "Eosinophilia in Liver Diet," Am. J. Med. Sci., February, 1930, 129, 199. CrossrefGoogle Scholar7 LEVINELADD SAWS: "Pernicious Anemia," Clinical Study of 150 Consecutive Cases with Special Reference to Gastric Anacidity, Johns Hopkins Hosp. Bulletin, August, 1921, 32, 254. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Ann Arbor, Michigan*From the Thomas Henry Simpson Memorial Institute for Medical Research, of the University of Michigan, Ann Arbor. Nextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byDie Erkrankungen des erythrocytären SystemsErkennung und Behandlung der AnämienPhysiologie und Pathologie des Antiperniciosaprinzips 1 March 1931Volume 4, Issue 9Page: 1105-1107KeywordsBloodDietEosinophiliaLiverPernicious anemiaReticulocytesStomach ePublished: 1 December 2008 Issue Published: 1 March 1931 PDF downloadLoading ...
Eosinophils and IgE Receptors: A Continuing Controversy
Authors: Hirohito Kita, Gerald J. Gleich
Journal: Blood (1997)

DURING THE PAST 2 decades, considerable new information has been obtained about the functions of the eosinophil and its roles in human disease. Presently, the eosinophil is recognized as a proinflammatory granulocyte implicated in protection against parasitic infections and believed to play a major
Cheaper HIV Drugs for Poor Nations Bring a New Challenge: Monitoring Treatment
Authors: Joan Stephenson
Journal: JAMA (2002)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Polyethylene Glycol Coatings on Plastic Substrates for Chemically Defined Stem Cell Culture
Authors: Samantha K. Schmitt, Angela W. Xie, Raha M. Ghassemi, David J. Trebatoski, William L. Murphy, Padma Gopalan
Journal: Advanced Healthcare Materials (2015)

Human mesenchymal stem cells (hMSCs) are a widely available and clinically relevant cell type with a host of applications in regenerative medicine. Current clinical expansion methods can lead to selective changes in hMSC phenotype potentially resulting from relatively undefined cell culture surfaces. Chemically defined synthetic surfaces can aid in understanding the influence of cell–material interactions on stem cell behavior. Here, a thin copolymer coating for hMSC culture on plastic substrates is developed. The random copolymer is synthesized by living free radical polymerization and characterized in solution before application to the substrate, ensuring a homogeneous coating and limiting the sample‐to‐sample variations. The ability to coat multiple substrate types and cover large surface areas is reported. Arg–Gly–Asp‐containing peptides are incorporated into the coating under aqueous conditions via their lysine or cysteine side chains, resulting in amide and thioester linkages, respectively. Stability studies show amide linkages to be stable and thioester linkages to be labile under standard serum‐containing culture conditions. In addition, chemically defined passaging of hMSCs using only ethylenediaminetetraacetic acid on polystyrene dishes is shown. After passage, the hMSCs can be seeded back onto the same plate, indicating potential reusability of the coating.
CXCL10 reduces melanoma proliferation and invasiveness in vitro and in vivo
Authors: F. Antonicelli, J. Lorin, S. Kurdykowski, S.C. Gangloff, R. Le Naour, J.M. Sallenave, W. Hornebeck, F. Grange, P. Bernard
Journal: British Journal of Dermatology (2010)

Melanoma is often infiltrated by inflammatory and immune cells that might either maintain chronic inflammation, therefore promoting tumour growth, or mount an antitumour response to control tumour outcome. In this setting, Th1-oriented lymphocyte infiltration is associated with a better outcome in melanoma. Although the interferon-induced protein CXCL10 is expressed by Th1 immune cells, its receptor was also shown to be involved in melanoma progression and metastasis.To investigate the CXCL10-mediated antitumoral response in vivo, and its clinical relevance. Methods C57BL/6 mice bearing B16F1 melanoma were treated intraperitoneally with an adenovirus vector expressing CXCL10. In addition, peripheral blood mononuclear cells (PBMC) from 20 patients, 10 with melanoma in remission and 10 with melanoma in progression, were assessed for their cytokine/chemokine content using a 30-plex assay, and for their ability to modulate melanoma invasion in vitro in Transwell(®) (Sigma-Aldrich) chambers coated with Matrigel(®) (BD Biosciences).Treatment with CXCL10 reduced melanoma tumour growth in C57BL/6 mice compared with controls in vivo, and reduced melanoma invasion in vitro. Screening for expression of 30 cytokine/chemokine proteins showed that only CXCL10 was significantly increased in patients in remission compared with patients in progression. PBMC only from patients in remission significantly reduced melanoma cell invasiveness in an ex vivo Transwell(®) assay. Accordingly, this inhibitory effect was also observed with PBMC culture media from patients with melanoma in remission.The quantitative increase in CXCL10 production, together with its ability to limit melanoma progression, shows the potential benefit of this chemokine to control melanoma progression or metastasis.
Abstract 13907: Statin-Induced Myopathy is Mediated by Isoprenoid Depletion and is Independent of Serum Cholesterol Levels
Authors: Jeffrey Lawrence, Carolyn Moyer, Mehrdad Ameri, Charley Dean, Betsy Russell, Shlece Alexander, Feng Cai, Brandon Ason, HQ Han, Ricardo Dent, Ren Xu, Graeme Moffat
Journal: Circulation (2014)

Statin use is associated with muscle-related side-effects (ie, MRSE) in ~10-20% patients and is the most common reason for discontinuation of treatment. Moreover, high-risk patients who have inadequately controlled LDL-C as a result of statin intolerance present a significant public health problem. A study to assess the role of cholesterol and/or isoprenoid intermediates of the cholesterol biosynthetic pathway in statin-induced myopathy was conducted in female rats treated with cerivastatin for 14 days. Cerivastatin treatment of rats fed standard diet induced myopathy in type II muscle fibers, but not in type I muscle fibers. Cholesterol supplementation in the diet of cerivastatin treated rats increased circulating cholesterol levels, but failed to prevent myopathy, suggesting that statin-mediated myopathy was independent of the cholesterol lowering effects of statins. Conversely, mevalonate supplementation of the diet abrogated cerivastatin induced myopathy evidenced by either microscopy or sensitive biomarkers of muscle injury including AST, CK, sTnI, FABP3, and urinary myoglobin. These data suggest that statin-induced myopathy involves a cholesterol biosynthetic intermediate upstream of cholesterol and downstream of mevalonate. Most animals with myopathy had increased expression of genes involved in stress (UCP1, NRF2), inflammation (Alox5ap), and autophagy/mitophagy (GABARAP), and decreases in genes involved in energy production (GATM, ATP5b, ATP5f1) or mitochondrial biogenesis (PGC-1α). These data suggest that sensitive muscle fibers may have deficits in mitochondrial biogenesis in the presence of increased autophagy/mitophagy that result in an energy crisis. In addition, many of these genes have also been reported to be changed in human statin myopathy, suggesting a similarity in mechanisms between rats and humans. In conclusion, cerivastatin-induced myopathy in rats involves a step upstream of cholesterol in isoprenoid intermediary metabolism that likely results in an energy crisis. These data suggest that lowering of cholesterol by mechanisms other than HMG CoA inhibition-associated isoprenoid intermediate depletion would not be expected to result in myopathy.
Studies on an inhibitor of vaccinia hemagglutinin.
Authors: Harold L. Wolin
Journal: Cancer Research (1961)

Summary  The inhibitor of vaccinia hemagglutinin appearing in the ascites of the Ehrlich carcinoma of the mouse has been characterized and partially purified. The biological and chemical properties of this substance indicate that it has much in common with inhibitors reported previously in other biological material and suggest that, like these, it, too, is mucoprotein in nature. The inhibitor is found not only in the ascites of the Ehrlich carcinoma but in the ascites of various other tumors of the mouse.
Abstract 3888: Expression of ABCG2, ALDH1A1, CD44, and CD44 variant 9 in human oral squamous cell carcinoma and its relationship with clinical factors
Authors: Tetsuya Tamatani, Natsumi Takamaru, Makoto Kinouchi, Nobuyuki Kuribayashi, Daisuke Uchida, Hirokazu Nagai, Youji Miyamoto
Journal: Cancer Research (2014)

Abstract [Background] A cancer stem cell (cancer initiating cell, CSC) is considered capable of self -replication, self-differentiation, drug resistance, and immune evasion. Recently, CSC has become increasingly important in the treatment of malignant tumors. Cancer stem cells express specific molecules termed CSC marker, including ATP-binding cassette, G2 subfamily (ABCG2), aldehyde dehydrogenase (ALDH) 1A1, CD44, and CD44 variant 9 (CD44v9), and their expression has been reported to be the potential prognostic values. However, the prognostic values of ABCG2, ALDH1A1, CD44, and CD44v9 expression in patients with oral cancer are less understood. [Purpose] The aims of present study were to evaluate the expression of ABCG2, ALDH1A1, CD44, and CD44v9 in oral squamous cell carcinoma (OSCC) and to elucidate the relationships among the CSC marker expression, clinical stages, histological differentiation, classification of invasion mode, lymph node metastasis and disease-free survival rate. [Materials and Methods] Tissue specimens were obtains from 99 patients with OSCC after surgery or biopsy. Immunohistochemistry was used to assess ABCG2, ALDH1A1, CD44, and CD44v9 protein using at least 10% staining-positive cells as the definition of positive staining. [Results] Immunohistochemical analysis of 99 cases of OSCC showed that CD44 and CD44v9 expression were strongly detected in all OSCC compared with normal epithelial cells. Twenty eight (28.2%) cases of 99 OSCC patients expressed ABCG2. There was no relationship between ABCG2 expression and clinical stages, histological differentiation, metastasis, or disease-free survival rate. There was significant association between ABCG2 expression and classification of invasion mode. Otherwise, thirty one (31.3%) cases of 99 OSCC patients expressed ALDH1A1. There was no relationship between ALDH1A1 expression and clinical stagesor metastasis. However, there was significant association between ALDH1 expression and histological differentiation, or classification of invasion mode or disease-free survivalrate. [Conclusions] These findings suggested that the expression of ALDH1A1 as CSC markers in OSCC may be good marker indicating survival in patients with OSCC. Citation Format: Tetsuya Tamatani, Natsumi Takamaru, Makoto Kinouchi, Nobuyuki Kuribayashi, Daisuke Uchida, Hirokazu Nagai, Youji Miyamoto. Expression of ABCG2, ALDH1A1, CD44, and CD44 variant 9 in human oral squamous cell carcinoma and its relationship with clinical factors. [abstract]. In: Proceedings of the 105th Annual Meeting of the American Association for Cancer Research; 2014 Apr 5-9; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2014;74(19 Suppl):Abstract nr 3888. doi:10.1158/1538-7445.AM2014-3888
Risk factors for diabetes and coronary heart disease
Authors: Sarah H Wild, Christopher D Byrne
Journal: BMJ (2006)

Body mass index at follow-up and relative risk for type 2 diabetes in participants in nurses' health study. Data derived from Colditz et al (see Further Reading box) 



Many cross sectional and prospective studies have confirmed the association between obesity and type 2 diabetes. Most people with type 2 diabetes are overweight or obese: more than 85% of people with type 2 diabetes in southeast Scotland in 2005 had a body mass index (weight in kilograms divided by height in metres squared) of over 25. Recent evidence indicates that high waist circumference may be an even better indicator than body mass index (BMI) of increased risk of type 2 diabetes. 

The risk of developing diabetes over a 14 year follow-up period (among nurses aged 30-55 years at baseline) in the nurses' health study was 49 times higher among women whose baseline BMI was >35 than among women whose baseline BMI was <22. Even a a slightly raised BMI (22.0-22.9) at follow-up was associated with an age adjusted relative risk of diabetes that was three times higher than that in women with a BMI of <22.0 at follow-up. 



Distribution of body mass index in people with diagnosis of type 2 diabetes in past two years, by age at diagnosis (based on 371, 1466, 1302 people aged 25-44, 45-64, and ≥65 respectively at diagnosis, in population based diabetes register in Lothian, Scotland) 



Similar findings have been reported for men from a United States cohort of 51 529 male health professionals aged 40-75 in 1986 who were followed until 1992. Those with a BMI of ≥35 had a relative risk of developing diabetes of 42 (95% confidence interval 22.0-80.6) compared with men with a BMI of <23.0 at age 21, after adjustment for age, smoking, and family history of diabetes. Moreover, earlier onset …