METABOLIC STUDIES IN PATIENTS WITH CANCER OF THE GASTROINTESTINAL TRACT. IX. EFFECTS OF DIETARY CONSTITUENTS UPON THE CHEMICAL COMPOSITION OF THE LIVER, ESPECIALLY IN PATIENTS WITH GASTROINTESTINAL CANCER
Authors: Jules C. Abels, Irving M. Ariel, Helen T. Murphy, George T. Pack, C. P. Rhoads
Journal: Annals of Internal Medicine (1944)

Article1 April 1944METABOLIC STUDIES IN PATIENTS WITH CANCER OF THE GASTROINTESTINAL TRACT. IX. EFFECTS OF DIETARY CONSTITUENTS UPON THE CHEMICAL COMPOSITION OF THE LIVER, ESPECIALLY IN PATIENTS WITH GASTROINTESTINAL CANCERJULES C. ABELS, M.D., IRVING M. ARIEL, M.D., HELEN T. MURPHY, PH.D., GEORGE T. PACK, M.D., C. P. RHOADS, M.D., F.A.C.P.JULES C. ABELS, M.D.Search for more papers by this author, IRVING M. ARIEL, M.D.Search for more papers by this author, HELEN T. MURPHY, PH.D.Search for more papers by this author, GEORGE T. PACK, M.D.Search for more papers by this author, C. P. RHOADS, M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-20-4-580 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptINTRODUCTIONIn a previous investigation the livers of patients with gastrointestinal cancer were found to have abnormally high concentrations of fat and probably low concentrations of glycogen.1This may be of clinical significance because, from the evidence, these changes render the liver abnormally susceptible to injury.2The physiological effects of these two constituents may be interrelated, as suggested by the fact that the livers of individuals exposed to several hepatotoxins are not damaged when considerable amounts of glucose are administered.3This effect apparently is not due simply to the increased amounts of hepatic glycogen deposited, but to the fact that...Bibliography1. ARIELABELSMURPHYPACKRHOADS IMJCHTGTCP: Metabolic studies in patients with cancer of the gastrointestinal tract. VIII. The chemical composition of the liver, especially in patients with gastrointestinal cancer, ANN. INT. MED., 1940, xx, 570-579. Google Scholar2. GREENE CH: Liver and biliary tract, a review for 1941, Arch. Int. Med., 1942, lxix, 691-714. CrossrefGoogle Scholar3. SOSKINHYMAN SM: Physiologic basis of intravenous dextrose therapy for diseases of the liver, Arch. Int. Med., 1939, lxiv, 1265-1270. CrossrefGoogle Scholar4. RAVDINVARSTHOROGOODSCHULTZJOHNSON ISHMEJJ: The liver glycogen and lipid concentrations following intravenous glucose administration and diet in the dog and man in the presence of liver damage, Ann. Surg., 1941, cxiv, 1018-1025. CrossrefGoogle Scholar5. MILLERWHIPPLE LIGH: Chloroform liver injury increases as protein stores decrease: studies in nitrogen metabolism in these dogs, Am. Jr. Med. Sci., 1940, cxcix, 204-216. CrossrefGoogle Scholar6. BOYCEMCFETRIDGE FFEM: Studies of hepatic function by the Quick hippuric acid test. III. Various surgical states, Arch. Surg., 1938, xxxvii, 443-445. CrossrefGoogle Scholar7. GREENE CH: Liver and biliary tract: a review of the literature for 1942, Arch. Int. Med., 1943, lxxii, 563-578. CrossrefGoogle Scholar8. HAWKINS WB: Liver and bile, in LUCK J. M. HALL V. E.: Ann. Rev. Physiol., 1941, iii, 259-282, Ann. Reviews, Inc., Stanford University, California. CrossrefGoogle Scholar9. RALLIRUBINRINZLER EPSHS: The liver lipids in normal human livers and in cases of cirrhosis and fatty infiltration of the liver, Jr. Clin. Invest., 1941, xx, 93-97. CrossrefGoogle Scholar10. DRAGSTEDTVAN PROHASKAHARMS LRJHP: Observations on a substance in pancreas (a fat metabolizing hormone) which permits survival and prevents changes in depancreatized dogs, Am. Jr. Physiol., 1936, cxvii, 175-181. CrossrefGoogle Scholar11. BESTFERGUSONHERSHEY CHGCJM: Choline and liver fat in diabetic dogs, Jr. Physiol., 1933, lxxix, 94-102. CrossrefGoogle Scholar12. GAVINMCHENRY GEW: Inositol: a lipotropic factor, Jr. Biol. Chem., 1941, cxxxix, 485. CrossrefGoogle Scholar13. Unpublished data. These Laboratories. Google Scholar14. ABELSREKERSBINKLEYPACKRHOADS JCPEGEGTCP: Metabolic studies in patients with cancer of the gastrointestinal tract. II. Hepatic dysfunction, ANN. INT. MED., 1942, xvi, 221-240. Google Scholar15. LONGKATZINFRY CNBEG: The adrenal cortex and carbohydrate metabolism, Endocrinology, 1940, xxvi, 309-344. CrossrefGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: New York, N. Y.*Received for publication June 9, 1943.From The Memorial Hospital for the Treatment of Cancer and Allied Diseases, New York City.The authors gratefully acknowledge a grant from the National Cancer Institute.†Finney-Howell Fellow.‡Trainee in diagnosis and treatment, National Cancer Research Institute. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 April 1944Volume 20, Issue 4Page: 580-589KeywordsAttentionCancer treatmentFatsGastrointestinal cancersGlucoseGlycogensHepatotoxinsLiver ePublished: 1 December 2008 Issue Published: 1 April 1944 PDF downloadLoading ...