Hypokalemia in the Hypertensive Patient
Authors: NORMAN M. KAPLAN
Journal: Annals of Internal Medicine (1967)

Article1 June 1967Hypokalemia in the Hypertensive PatientWith Observations on the Incidence of Primary AldosteronismNORMAN M. KAPLAN, M.D., F.A.C.P.NORMAN M. KAPLAN, M.D., F.A.C.P.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-66-6-1079 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptHypokalemia has been used as the major diagnostic criterion for the diagnosis of primary aldosteronism. With this criterion, the prevalence of primary aldosteronism among the hypertensive population has been exceedingly small, with probably fewer than 1,000 cases having been recognized in the United States where the number of hypertensives has been estimated at 17 million (1).Conn (2) has recently proposed that primary aldosteronism is much more commonly found in normokalemic patients, suggesting that the prevalence may be 20% of the hypertensive population. 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Author, Article, and Disclosure InformationAffiliations: Dallas, TexasFrom the Department of Internal Medicine, The University of Texas Southwestern Medical School, Dallas, Tex.This study was supported by grant AM-06938-04, National Institute of Arthritis and Metabolic Diseases, and grant 5T01-GM 1421-01, National Institute of General Medical Sciences, National Institutes of Health, Bethesda, Md., and by the Dallas Heart Association, Dallas, Tex.This work was presented in part at the annual meeting of the American Society for Clinical Investigation, Endocrinology Section, Atlantic City, N. J., May 1, 1966.Requests for reprints should be addressed to Norman M. Kaplan, M.D., 5323 Harry Hines Blvd., Dallas, Tex. 75235. 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SCOGGINS, Ph.D., CATHERINE J. ODDIE, M.Sc., WILLIAM S. C. HARE, M.D., JOHN P. COGHLAN, Ph.D.The generation and maintenance of metabolic alkalosisDynamic Changes in Plasma Aldosterone and Cortisol Levels and Renin Activity in Patients with Oligosymptomatic Adrenocortical Hypertension Simulating Essential HypertensionAldosterone, Deoxycorticosterone, and Corticosterone Metabolism in Benign Essential HypertensionMineralocorticoidsyndromeThe pattern of plasma renin activity and aldosterone secretion in normal and hypertensive subjects before and after saline infusionsThe pattern of electrolyte excretion in normal and hypertensive subjects before and after saline infusionsSystemic Arterial Hypertension in Pediatric PracticeHypermineralocorticoidismus und HypertonieREFERENCESHypertension, Adrenal Abnormalities, and Alterations in Plasma Renin ActivityJ. CAULlE GUNNELLS JR., M.D., F.A.C.P., W. L. MCGUFFIN JR., M.D., R. R. ROBINSON, M.D., F.A.C.P., C. E. GRIM, M.D., SAMUEL WELLS, M.D., DONALD SILVER, M.D., J. F. GLENN, M.D.Renal electrolyte cycles and mechanism of nocturia in primary aldosteronismOn the pathogenesis of metabolic alkalosis in hyperaldosteronismPlasmareninaktivit�t bei Hypertonien unter Stimulations- und SuppressionsbedingungenThe Control of Aldosterone Secretion and Its Relationship to the Diagnosis of HyperaldosteronismCase 17-1969Primary Aldosteronism: Diagnosis and TreatmentProgress in the Diagnosis of Secondary HypertensionA FIRST-ARCH SYNDROME VARIANT ?DIAGNOSING PRIMARY HYPERALDOSTERONISMIncidence of Suppressed Renin Activity and of Normokalemic Primary Aldosteronism in Hypertensive Negro PatientsSurgery of the Adrenal GlandRenin-Angiotensin-Aldosteronsystem bei Störungen der Blutdruckregulation 1 June 1967Volume 66, Issue 6Page: 1079-1090KeywordsArthritisEndocrinologyExcretionHeart diseasesHypertensionLongitudinal studiesMetabolic disordersPlasma renin activity Issue Published: 1 June 1967 CopyrightCopyright ©, 1967, by The American College of PhysiciansPDF DownloadLoading ...