tbuckley/cabot-search huggingface dataset:
Abstract 19525: Number and Function of Endothelial Progenitor Cells in Patients with Chronic Heart Failure and Healthy Subjects - Is Exercise Training Equally Effective in the Elderly?
Authors: Marcus Sandri, Norman Mangner, Robert Höllriegel, Sandra Erbs, Axel Linke, Volker Adams, Sven Möbius-Winkler, Gerhard Schuler, Stephan Gielen
Journal: Circulation (2010)

Background: A reduction in number and function of endothelial progenitor cells (EPCs) occurs in both physiologic aging and chronic heart failure (CHF). It has, however, never been assessed, if dise...
Abstract 14821: Long-Term Follow-up After Alcohol Septal Ablation for Hypertrophic Obstructive Cardiomyopathy in Young Adults
Authors: Amir-Ali Fassa, Bertrand Cormier, Marie-Claude Morice, Jean-Francois Piechaud, Marie-Christine Malergue, Yves Louvard, Philippe Garot, Thierry Lefevre
Journal: Circulation (2011)

Aim: To assess the long-term safety and efficacy of alcohol septal ablation (ASA) in young adults. Methods: Data of 163 consecutive patients who underwent ASA at our institution from 2000 to 2010 w...
EuroTravNet: imported Chagas disease in nine European countries, 2008 to 2009
Authors: J A Pérez-Molina, A Perez-Ayala, P Parola, Y Jackson, S Odolini, R Lopez-Velez, None for the EuroTravNet Network
Journal: Eurosurveillance (2011)

In recent years, Chagas disease has emerged as a disease of importance outside of endemic areas, largely as a result of migration. In Europe, clinicians may have to treat infected migrants from endemic areas as well as people with acute infections transmitted congenitally,through organ donation or blood transfusion.We describe here the characteristics of patients diagnosed with chronic Chagas disease at the core clinical sites of the EuroTravNet network during 2008 and 2009. Of the 13,349 people who attended the sites, 124 had chronic Chagas disease. Most (96%) were born in Bolivia and the median number of months in the country of residence before visiting a EuroTravNet core site was 38 months (quartile (Q₁)–Q₃: 26–55). The median age of the patients was 35 years (Q₁–Q₃: 29–45) and 65% were female. All but one were seen as outpatients and the most frequent reason for consultation was routine screening. Considering that Chagas disease can be transmitted outside endemic regions and that there is effective treatment for some stages of the infection, all migrants from Latin America (excluding the Caribbean) should be questioned about past exposure to the parasite and should undergo serological testing if infection is suspected.
Comorbidity of parental anxiety disorders as risk for childhood-onset anxiety in inhibited children
Authors: J F Rosenbaum, J Biederman, E A Bolduc, D R Hirshfeld, S V Faraone, J Kagan
Journal: American Journal of Psychiatry (1992)

Previous work suggested that children of parents with panic disorder and agoraphobia were likely to be classified as behaviorally inhibited and that behaviorally inhibited children were likely to develop anxiety disorders. However, the factors determining which inhibited children were at risk for childhood onset of anxiety disorders remained unknown. The authors of this study hypothesized that greater anxiety loading in parents would increase the risk for anxiety disorders in children with behavioral inhibition.Using DSM-III structured interviews, the authors examined patterns of aggregation of anxiety disorders in parents of two existing cohorts of children, one cross-sectional and clinically derived (31 children, 60 parents) and the other epidemiologically derived and longitudinal (40 children, 75 parents). Within each cohort, parents were stratified into three groups based on the presence (behavioral inhibition and anxiety) or absence (behavioral inhibition only, no behavioral inhibition and no anxiety) of behavioral inhibition and two or more anxiety disorders in their child.Parents of children with behavioral inhibition and anxiety, from both the clinical and nonclinical cohorts, had significantly higher rates of two or more anxiety disorders than did parents of children with behavioral inhibition only and parents of children with no behavioral inhibition and no anxiety.These results indicate that the presence of parental loading for anxiety disorders may help to identify the subgroup of inhibited children at very high risk for developing childhood-onset anxiety disorders.
Death from ipecac intoxication in a patient with anorexia nervosa
Authors: E J Friedman
Journal: American Journal of Psychiatry (1984)

A patient with anorexia nervosa developed a fatal cardiomyopathy due to ipecac intoxication. Prodromal signs and symptoms included generalized muscle weakness, dysphagia, and severe palpitations. Autopsy revealed pathological changes in the heart and skeletal muscles.
Differences in death rates in English hospitals
Authors: T. Hennell, J. P Bunker, N. Black
Journal: BMJ (1999)

Cancellation of debt must ensure maximum benefit to vulnerableEditor-It should be difficult for any doctor to ignore Abbasi's recent article on "third world" debt. 1 The state of health care available to families in between half and two thirds of the world is unacceptable, and the great differences in quality of health care between rich and poor countries are unethical. 2However, the experiences of our aid agency in trying to develop hospital care for children in disadvantaged countries leads us to be cautious about advocating simply a cancellation of debts.We have witnessed that an input of money alone to countries which are poorly governed, and where corruption is a way of life, may fail to reach the most vulnerable and needy within the community.Our agency's view is that all debt to poor and disadvantaged countries should be cancelled but in a more sustainable way than by releasing states from their repayments.Money earmarked for debt repayment should be retrieved but ploughed back fully and immediately into the country's healthcare and education systems.We suggest that this is implemented through the appointment in each repaying country of carefully chosen advocates for women and children.Ideally, partners appointed from within the United Nations should support these local delegates.A committee formed between the UN partners and delegates from the country repaying the debt should thereby ensure that all the money that has been repaid to rich countries is used for health care and education.Such a system would be more difficult to organise than simple cancellation of debt.Care would have to be taken to ensure that existing levels of finance for health care and education are maintained in addition to money resulting from debt repayment.The repayment of debts by the "third world" to rich countries who have prospered from earlier exploitation clearly represents an evil.However, our response to this should be "street wise" and should ensure that the abolition of debt results in maximum benefit to the most vulnerable members of disadvantaged countries.
The rise of ampicillin-resistant Enterococcus faecium high-risk clones as a frequent intestinal colonizer in oncohaematological neutropenic patients on levofloxacin prophylaxis: a risk for bacteraemia?
Authors: A.M. Sánchez-Díaz, C. Cuartero, J.D. Rodríguez, S. Lozano, J.M. Alonso, M. Rodríguez-Domínguez, A.P. Tedim, R. del Campo, J. López, R. Cantón, P. Ruiz-Garbajosa
Journal: Clinical Microbiology and Infection (2015)
Automatic detection of colon AT CT colonography
Authors: TA Chowdhury, RJT Sadleir, PF Whelan, N Sezille, A Moss, A O'Hare, S Foley, H Fenlon, P MacMathuna
Journal: Endoscopy (2005)

Aim: CT colonography (CTC) is a minimally invasive alternative to conventional colonoscopy for imaging the human colon. We introduce a novel method for automatic segmentation of the colon from an abdominal CT datasets.
Abstract 1412: Sonic Hedgehog Gene Transfer Promotes Angiogenesis and Myocardial Regional Blood Flow via PKC Dependent Netrin Expression
Authors: Rafeeq P Ahmed, Husnain K Haider, Shujia Jiang, Muhammed R Afzal, Muhammed Ashraf
Journal: Circulation (2008)

Background: Hedgehog signaling effects endothelial and fibroblast cell migration and vascularization of various tissues during embryonic development. We propose here that stem cell based Shh gene delivery to the heart promotes neovascularization and enhances regional blood flow (RBF) in the infartced heart. Methods and Results: The pCMVShh plasmid was constructed and used for non-viral transfection of primary mesenchymal stem cell (MSC) culture. Successful transfection and expression of Shh in transfected MSCs ( Shh MSCs) was confirmed by immunoflourescence, real-time PCR and Western blotting. Real-time PCR based array showed upregulation of angiogenic factors in Shh MSCs including netrin (&gt;62-fold) and iNOS (&gt;100-fold). The expression of netrin and iNOS was PKC dependent and was abolished in the presence of 2.5 μ M chelerythrin. Transduction of iNOS gene into MSCs increased netrin expression implying a role for iNOS downstream of PKC. Western blot showed that 45-KDa PKM proteolytic subunit of PKC was involved in this activity. Shh MSCs conditioned medium was biologically active and caused greater migration and tube formation of human vascular endothelial in vitro in comparison with untransfected MSCs ( non-Shh MSCs) conditioned medium. For in vivo studies, 70 μ l DMEM without cells (group-1) or containing 1x10 6 male non-Shh MSC (group-2), or Shh MSCs (group-3) were transplanted into female rat model of acute coronary artery ligation. S ry -gene studies on day-4 after cell engraftment showed higher survival of Shh MSCs ( p &lt; 0.05 vs non-Shh MSC). Immunostaining for vWillebrand Factor-VIII and smooth muscle actin showed robust angiogenesis with distinctly large vessels in group-3 ( p &lt; 0.001 vs group-2). RBF measured by fluorescent microspheres was increased ( p &lt; 0.01 ) and infarction size was attenuated ( p &lt; 0.05 ) in group-3 as compared with control groups. Left ventricle ejection fraction (52.3±2.6%) and fractional shortening (21.8±1.2%) were more preserved in group-3 as compared with control groups. Conclusions: Ex-vivo Shh gene delivery improves angiogenesis and RBF in the infarcted heart to preserve global heart function through the upregulation of multiple angiogenic cytokines including iNOS and netrin.
Abstract 3894: Clinical Presentation and Predictors of In-hospital Mortality in Acute Heart Failure Patients With Preserved Left Ventricular Ejection Fraction: The ALARM Registry
Authors: John Parissis, Dimitrios Farmakis, Alexandre Mebazaa, Ignatios Ikonomidis, Juan Delgado, Fabio Villas-Boas, Antony McLean, Ferenc Follath
Journal: Circulation (2009)
Philadelphia-Like Signature In Childhood Acute Lymphoblastic Leukemia: The AIEOP Experience
Authors: Geertruy te Kronnie, Daniela Silvestri, Elena Vendramini, Grazia Fazio, Franco Locatelli, Valentino Conter, Chiara Borga, Maria Grazia Valsecchi, Andrea Biondi, Giuseppe Basso, Giovanni Cazzaniga
Journal: Blood (2013)
Abstract 32: Global Burden and Control of Hypertension in 2010: Analysis of Population-Based Studies from 89 Countries
Authors: Katherine T Mills, Joshua D Bundy, Tanika N Kelly, Jennifer E Reed, Patricia M Kearney, Kristi Reynolds, Jing Chen, Jiang He
Journal: Circulation (2015)

Background: Hypertension is an important global health challenge due to its high prevalence and resulting cardiovascular disease and chronic kidney disease. Hypertension is the leading preventable risk factor for premature death and disability worldwide. Objective: We estimated the prevalence, awareness, treatment and control of hypertension worldwide in 2010 and compared the global burden of hypertension in 2000 and 2010. Methods: We searched MEDLINE for published reports from January 1, 2001 to June 30, 2014 and supplemented with manual searches of references from retrieved articles. We included population-based studies and applied sex-age-specific prevalence of hypertension from each country to population data to assess the number of hypertensive adults in each region and globally. Proportions of awareness, treatment and control from each country were applied to hypertensive populations to obtain regional and global estimates. Results: An estimated 29.8% (95% confidence interval 29.6-30.0%) of the world’s adult population in 2010 had hypertension (30.7% [30.4-31.0%] in men and 28.8% [28.6-29.0%] in women). The estimated total number of hypertensive adults in 2010 was 1.33 billion (1.32-1.34 billion); 346 million (336-356 million) in high-income and 985 million (977-994 million) in low- and middle-income countries. From 2000 to 2010, the age-standardized prevalence of hypertension increased by 2.5% worldwide. The hypertension prevalence decreased 3.5% in high-income countries, whereas the prevalence increased 4.5% in low- and middle-income countries. In addition, from 2000 to 2010 the number of hypertensive adults increased by 354 million (334 million in low- and middle-income countries compared to 19 million in high-income countries). Proportions of hypertension awareness, treatment and control worldwide in 2010 were 43.5% (43.1-44.0%), 33.8% (33.3-34.2%), and 12.3% (12.1-12.6%), respectively. The proportion of hypertension control was 27.7% (27.0-28.3%) in high-income and 6.9% (6.7-7.1) in low- and middle-income countries. Conclusions: Prevention and treatment of hypertension should be a global health priority due to its high prevalence and low control rate globally, especially in low- and middle-income countries.
Corrigendum re: “Effect of a Risk-stratified Grade of Nerve-sparing Technique on Early Return of Continence After Robot-assisted Laparoscopic Radical Prostatectomy” [Eur Urol 2013;63:438–44]
Authors: Abhishek Srivastava, Sameer Chopra, Anthony Pham, Prasanna Sooriakumaran, Matthieu Durand, Bilal Chughtai, Siobhan Gruschow, Alexandra Peyser, Niyati Harneja, Robert Leung, Richard Lee, Michael Herman, Brian Robinson, Maria Shevchuk, Ashutosh Tewari
Journal: European Urology (2015)
Abstract 11472: Direct Induction of Human Cardiac Progenitor Cells to Functional Cardiomyocytes by Defined Factors
Authors: Suguru Tarui, Junko Kobayashi, Masataka Hirata, Masashi Yoshida, Atsushi Tateishi, Sadahiko Arai, Shingo Kasahara, Shunji Sano, Hidemasa Oh
Journal: Circulation (2011)

Background- The mortality of hypoplastic left heart syndrome (HLHS), characterized by hypoplasia of the left heart and aorta, remains the highest among congenital heart disease. Although recent wor...
Abstract 13698: Diagnostic Value of Non-Enhanced Multidetector Computed Tomography for Ruling Out Acute Aortic Dissection in Patients Presenting With Chest Pain or Back Pain
Authors: Shingo Sakamoto, Norimasa Taniguchi, Shunsuke Nakajima, Akihiko Takahashi
Journal: Circulation (2011)

Background: Acute aortic dissection (AAD) is a life-threatening disorder which should be included in the differential diagnosis of patients presenting with acute chest pain or back pain to emergenc...
Abstract 19480: Young African Americans with Nonischemic Cardiomyopathies and Wide QRS Intervals Are At Higher Risk of Elevated Defibrillation Threshold
Authors: Cody S Deen, J p Mounsey, Anil K Gehi, Eugene H Chung
Journal: Circulation (2010)

Introduction: Routine defibrillator function threshold (DFT) testing for all patients undergoing implantable cardioverter defibrillator (ICD) implantation has been recently called into question. We...
Extracts from "Concise Clinical Evidence": Chronic suppurative otitis media * Commentary: Interpreting the evidence
Authors: J. Acuin
Journal: BMJ (2002)

Definition Chronic suppurative otitis media is a persistent inflammation of the middle ear or mastoid cavity.Synonyms include "chronic otitis media (without effusion)," chronic mastoiditis, and chronic tympanomastoiditis.Chronic suppurative otitis media is characterised by recurrent or persistent ear discharge (otorrhoea) over 2-6 weeks through a perforation of the tympanic membrane.Typical findings also include thickened granular middle ear mucosa, mucosal polyps, and cholesteatoma within the middle ear.Chronic suppurative otitis media is differentiated from chronic otitis media with effusion, in which there is an intact tympanic membrane with fluid in the middle ear but no active infection.Chronic suppurative otitis media does not include chronic perforations of the eardrum, which are dry, or discharge only occasionally, and have no signs of active infection.
Mortality in Spain during the heat waves of summer 2003
Authors: F Simon, G Lopez-Abente, E Ballester, F Martinez
Journal: Eurosurveillance (2005)

The effect of the elevated temperatures on mortality experienced in Europe during the summer of 2003 was observed in several countries. This study, carried out in Spain, describes mortality between 1 June and 31 August and evaluates the effect of the heat wave on mortality. Observed deaths were obtained from official death registers from 50 provincial capitals. Observed deaths were compared with the expected number, estimated by applying a Poisson regression model to historical mortality series and adjusting for the upward trend and seasonality observed. Meteorological information was provided by the Instituto Nacional de Meteorologia (National Institute of Meteorology). Spain experienced three heat waves in 2003. The total associated excess deaths were 8% (43 212 observed deaths compared with 40 046 expected deaths). Excess deaths were only observed in those aged 75 years and over (15% more deaths than expected for the age group 75 to 84 and 29% for those aged 85 or over). This phenomenon (heat-associated excess mortality) is an emerging public health problem because of its increasing attributable risk, the aging of the Spanish population and its forecasted increasing frequency due to global warming. The implementation of alert and response systems based on monitoring of climate-related risks, emergency room activity and mortality, and strengthening the response capacity of the social and health services should be considered.
DSM-IV field trial: obsessive-compulsive disorder [published erratum appears in Am J Psychiatry 1995 Apr;152(4):654]
Authors: E B Foa, M J Kozak, W K Goodman, E Hollander, M A Jenike, S A Rasmussen
Journal: American Journal of Psychiatry (1995)

Three issues relevant to revising the DSM-III-R criteria for obsessive-compulsive disorder were examined in a field trial: 1) the requirement that symptoms of obsessive-compulsive disorder be viewed by the patient as excessive or unreasonable, 2) the presence of mental compulsions in addition to behavioral compulsions, and 3) ICD-10 subcategories.The authors studied symptom patterns of obsessive-compulsive disorder as well as strength of obsessive belief among 431 patients with obsessive-compulsive disorder at seven hospital outpatient clinics. Two methods of subject selection were used: consecutive entry of everyone who contacted the clinics for evaluation of obsessive-compulsive disorder and entry of patients with obsessive-compulsive disorder who had continuing contact with the clinics since before the field trial and who were still symptomatic. Primary measures were the Yale-Brown Obsessive Compulsive Scale and face-valid questions about fixity of obsessive-compulsive beliefs.The large majority of patients were uncertain about whether their obsessive-compulsive symptoms were unreasonable or excessive, and most had both mental and behavioral compulsions. Results on the ICD-10 subcategories were equivocal.The present results converge with previous findings to indicate a broad range of insight among patients with obsessive-compulsive disorder. The DSM-III-R requirement for insight should be de-emphasized in DSM-IV, and mental rituals should be included in the definition of compulsions.
Abstract 241: Direct Injection of Bone Marrow Mononuclear Cells Reversed Experimental Diabetic Neuropathy by Augmenting Neovascularization and Providing Angio-neurotrophic Cytokines
Authors: Hyongbum Kim, Yong Jin Choi, Jong-seon Park, Masaaki Ii, Marcy Silver, Rolf Pfannl, Allan Ropper, Young-sup Yoon
Journal: Circulation (2007)

Background: Bone marrow (BM)-derived mononuclear cells (MNCs) have been shown to effectively treat ischemic cardiovascular diseases. Recent evidence suggested that diabetic neuropathy (DN) is causally related to impaired angio-vasculogenesis in vasa nervorum and deficiency of angiogenic and neurotrophic factors. Accordingly, we sought to investigate whether DN can be ameliorated by local injection of BM-derived MNCs. Methods and Results: A severe peripheral neuropathy, characterized by significant slowing of motor nerve conduction velocities (MCV) developed 12 wks after the induction of diabetes with streptozotocin in Fisher rats (vs normal rats; 46.6±2.6 vs 32.0±2.5 m/s, P &lt; 0.05). These rats were randomly assigned to MNC or saline injection groups (n = 9, each group) and received either 5x106 MNCs or saline intramuscularly around the sciatic nerves. In the MNC group, MCV were significantly improved within 4 wks after treatment (MNC vs Saline, 41.9±3.2 vs 32.7±2.8 m/s, P &lt; 0.01). Microvascular circulation of sciatic nerve, measured by laser Doppler perfusion imaging was markedly increased only in the MNC group. Capillary density at 4 wks was significantly higher in the MNC group than in the saline group (68±5.9 vs 37±4.4 /cross section, P &lt; 0.01). Robust engraftment of MNCs were observed in sciatic nerves, which sustained over 4 wks. A fraction of engrafted MNCs expressed endothelial markers suggestive of transdifferentiation into endothelial cells in the vasa nervorum. Intriguingly, a large number of the engrafted MNCs are following the course of vasa nervorum in close proximity. Real-time RT-PCR on sciatic nerves revealed that the expression of angio-neurotrophic factors were significantly increased in the MNC group compared to the saline group: VEGF (2.1 fold), FGF-2 (2.4), eNOS (18.1), Brain-derived neurotrophic factor (35.1), IGF-1 (25.5) (all P &lt; 0.05). The protein levels were well correlated with mRNA expression levels. Conclusion: Local transplantation of BM-derived MNCs could improve experimental DN by augmenting neovascularization and increasing angiogenic and neurotrophic factors in peripheral nerves. These findings suggest that BM-MNC transplantation may represent a novel therapeutic option for treating DN.
Abstract 171: PDE5A Inhibition Suppresses Maladaptive but Not Physiological Cardiac Hypertrophy
Authors: Thomas J Mulhearn, Hazim El-Haddad, Mobusher Mahmud, Milena Gebska, Azeb Haile, Michael Bridges, Djahida Bedja, Kathy Gabrielson, Anna R Hemnes, David A Kass, Hunter C Champion
Journal: Circulation (2006)
Gastroesophageal Acid Reflux Control 5 Years After Antireflux Surgery, Compared With Long-term Esomeprazole Therapy
Authors: Jan G. Hatlebakk, Frank Zerbib, Stanislas Bruley des Varannes, Stephen E. Attwood, Christian Ell, Roberto Fiocca, Jean-Paul Galmiche, Stefan Eklund, Göran Långström, Tore Lind, Lars R. Lundell
Journal: Clinical Gastroenterology and Hepatology (2015)
Abstract 14559: Monthly and Seasonal Variation in Sudden Cardiac Arrest Utstein Registry Study in Japan
Authors: Kunihiro Nishimura, Yoshinori Miyamoto, Fumiaki Nakamura, Makoto Watanabe, Yuji Nishiwaki, Tomonori Okamura
Journal: Circulation (2011)

Background : Previous studies have demonstrated seasonal variation in the incidence of acute myocardial infarction (AMI) with an increase in cases during the winter months. However, some studies sh...
Abstract 15893: Associations Between Serum Adiponectin, Vascular O2- Generation and NO Bioavailability In Patients With Coronary Atherosclerosis
Authors: Charalambos Antoniades, Cheerag Shirodaria, Paul Leeson, Constantinos Bakogiannis, Michael Demosthenous, Alexios Antonopoulos, Dimitris Tousoulis, Antigoni Miliou, Christodoulos Stefanadis, Keith M Channon
Journal: Circulation (2010)

Background: Evidence suggests that adiponectin, an adipokine produced by adipose tissue, may have an anti-inflammatory and antioxidant role in human atherosclerosis. However, very little is known r...