tbuckley/cabot-search huggingface dataset:
Differences Between Primary Care Physicians and Cardiologists in Management of Congestive Heart Failure: Relation to Practice Guidelines 11This work was supported in part by unrestricted grants from Bristol-Myers Squibb Co., Princeton, New Jersey; Burroughs Wellcome Co., Research Triangle Park, North Carolina; Merck &amp; Co., West Point, Pennsylvania; and the Department of Veterans Affairs Research Service.22All editorial decisions for this article, including selection of referees, were made …
Authors: Martin E Edep, Nihir B Shah, Ida M Tateo, Barry M Massie
Journal: Journal of the American College of Cardiology (1997)
Inspiratory vs expiratory resistance in diagnosing vocal cord dysfunction in children
Authors: Iulia Ioan, Romain Clisson, Claude Bonabel, Laurianne Coutier, François Marchal, Cyril Schweitzer, Silvia Varechova
Journal: European Respiratory Journal (2014)

The diagnosis of vocal cord dysfunction (VCD) relies on laryngoscopy, a rather invasive procedure that may not be readily available in the lung function lab during attacks. An alternative identification of the paradoxical glottis adduction during inspiration could be provided by the forced oscillation technique at a single frequency, allowing to describe the time course of respiratory resistance (Rrs). Rrs is dependent on the glottis calibre which narrows during expiration in normal subjects. In VCD, Rrs should increase during inspiration. The hypothesis was tested that the Rrs difference between inspiration and expiration (Rrs i-e ) is at variance between VCD and asthma.  Six VCD patients and 36 asthmatics underwent bronchial challenge. Rrs i-e  was 0.51 ± 2 hPa.s/L in VCD vs -0.37 ± 1 hPa.s/L in controls (pl0.03) at baseline. A typical Rrs vs Flow relationship after challenge is shown.  The average Rrs i-e  after challenge was 6 ± 5 hPa.s/L in VCD vs -0.5 ± 1 hPa.s/L in asthma (pl0.0001).  These measurements of Rrs are thus consistent with vocal cord adduction in inspiration in VCD but not asthma, a pattern exacerbated during the bronchial challenge.
Respiratory function in rats submitted to pharmacological hypothyroidism
Authors: Walter Zin, Valmara Pereira, Viviane Cagido, Gaudio Sena, Vanessa Baldez, Marcelo Einicker-Lamas, Vania Correa-da-Costa
Journal: European Respiratory Journal (2011)

Hypothyroidism has been associated with hypoventilation, decreased respiratory muscle strength and fatigue. However, the impact of chronic hypothyroidism on respiratory mechanics has not been described so far. Male Wistar rats were divided in 3 groups: Control (C, n=3), hypothyroidism (H, n=5), and hypothyroidism + T4 replacement (HR, n=5). H and HR groups received 0.03% methimazole (MMI) in drinking water for 21 days, followed by saline or T4 (1 μg/100 g BW) injections daily during the last 10 experimental days, respectively. Then, respiratory mechanics was determined during spontaneous breathing [respiratory system (RS)] and under mechanical ventilation after muscle paralysis (RS, lung and chest wall). Total lipid content in broncoalveolar lavage fluid (BALF) and lung histology were assessed. During spontaneous breathing, RS elastic recoil and inspiratory muscle pressure (Pmus,i) were lower in H group than in C (p=0.016 and p=0.011, respectively). The time required for Pmus,i to decay to zero was higher in H animals than in C or HR groups (p
The Subtle Benefit of Anticoagulant Therapy for Splanchnic Vein Thrombosis
Authors: Jack Ansell
Journal: JAMA Internal Medicine (2015)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Internal Medicine HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Internal Medicine journal
Geographical variations in the prevalence of atopic sensitization in six study sites across Canada
Authors: M. Chan‐Yeung, N. R. Anthonisen, M. R. Becklake, D. Bowie, A. Sonia Buist, H. Dimich‐Ward, P. Ernst, M. R. Sears, H. C. Siersted, L. Sweet, L. Van Til, J. Manfreda
Journal: Allergy (2010)

To cite this article: Chan‐Yeung M, Anthonisen NR, Becklake MR, Bowie D, Sonia Buist A, Dimich‐Ward H, Ernst P, Sears MR, Siersted HC, Sweet L, Van Til L, Manfreda J. Geographical variations in the prevalence of atopic sensitization in six study sites across Canada. Allergy 2010; 65 : 1404–1413. Abstract Background: Geographical variations in atopic sensitization in Canada have not been described previously. This study used the standardized protocol of the European Community Respiratory Health Survey‐1 (ECRHS‐1) to investigate the distribution and predictors of atopic sensitization in six sites across Canada and to compare the results with some ECRHS‐1 centers. Methods: Adults aged 20–44 years in six study sites across Canada underwent allergy skin testing using 14 allergens ( Dermatophagoides pteronyssinus , Dermatophagoides farinae ) cat, cockroach, grasses (Timothy grass, Kentucky grass), molds ( Cladosporium herbarium, Alternaria alternata , Aspergillus fumigatus , Penicillium ), trees (tree mix, birch, Olea europea ), and common ragweed. Results: The overall prevalence of atopy (skin test over 0 mm to any allergen) was 62.7%. There was significant geographical variation in the prevalence of atopy in the six study sites (lowest 55.6% [95% C.I.51.3–59.9] in Prince Edward Island, highest 66.0 [61.7–70.3] in Montreal) and of sensitization to each of the allergens tested even after adjustment for confounders. When the first eight of the nine allergens in the ECRHS were used to estimate the prevalence of atopic sensitization, the prevalence of atopy in Canada was 57% compared with 35.2% overall for centers in the ECRHS. The prevalence of atopy in Vancouver (57% [52.3–61.8]) was close to that of Portland, Oregon (52.1% [46.2–58.0]). Conclusion: There was a significant variation in atopic sensitization among different study sites across Canada. The prevalence of atopic sensitization is relatively high in Canada compared with sites in the ECRHS and this may, in part, account for the high prevalence of asthma and asthma symptoms in Canada.
Acetaminophen During Pregnancy May Affect Offspring’s Testes
Authors: Tracy Hampton
Journal: JAMA (2015)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Me, Myself & Irene
Authors: Rita Baron-Faust
Journal: BMJ (2000)

20th Century Fox 

Directed by Bobby and Peter Farrelly 

On worldwide general release; opened in the United Kingdom 22 September

Rating: 0

The premise of Me, Myself & Irene must have seemed irresistibly clever to the film's producers and a natural for the chameleon comic Jim Carrey. A mentally ill motorcycle cop with a “split” personality—one sweetly passive, the other violently aggressive—ends up running from the law to save a pretty blonde from gangsters, while his dual selves battle each other for her affections along the way.

Carrey's character, Charlie Baileygates, is diagnosed with “advanced delusionary …
Sex hormones and risk of breast cancer in premenopausal women: a collaborative reanalysis of individual participant data from seven prospective studies
Authors: T J Key, P N Appleby, G K Reeves, R C Travis, A J Alberg, A Barricarte, F Berrino, V Krogh, S Sieri, L A Brinton, J F Dorgan, L Dossus, M Dowsett, A H Eliassen, R T Fortner, S E Hankinson, K J Helzlsouer, J Hoff man-Bolton, George W Comstock, R Kaaks, L L Kahle, P Muti, K Overvad, P H M Peeters, E Riboli, S Rinaldi, D E Rollison, F Z Stanczyk, D Trichopoulos, S S Tworoger, P Vineis
Journal: The Lancet Oncology (2013)

BackgroundThe relationships of circulating concentrations of oestrogens, progesterone and androgens with breast cancer and related risk factors in premenopausal women are not well understood. MethodsIndividual data on prediagnostic sex hormone and sex hormone binding globulin (SHBG) concentrations were contributed by 7 prospective studies.Analyses were restricted to women who were premenopausal and under age 50 at blood collection, and to breast cancer cases diagnosed before age 50.The odds ratios (ORs) with 95% confidence intervals (95% CIs) for breast cancer associated with hormone concentrations were estimated by conditional logistic regression in up to 767 cases and 1699 controls matched for age, date of blood collection, and day of cycle, with stratification by study and further adjustment for cycle phase.The associations of hormones with risk factors for breast cancer in control women were examined by comparing geometric mean hormone concentrations in categories of these risk factors, adjusted for study, age, phase of menstrual cycle and body mass index (BMI).All statistical tests were two-sided. FindingsORs for breast cancer associated with a doubling in hormone concentration were 1.19 (95% CI 1.06-1.35)for oestradiol, 1.17 (1.03-1.33)for calculated free oestradiol, 1.27 (1.05-1.54)for oestrone, 1.30 (1.10-1.55)for androstenedione, 1.17 (1.04-1.32)for DHEAS, 1.18 (1.03-1.35)for testosterone and 1.08 (0.97-1.21) for calculated free testosterone.Breast cancer risk was not associated with luteal phase progesterone (for a doubling in concentration OR=1.00 (0.92-1.09)), and adjustment for other factors had little effect on any of these ORs.The cross-sectional analyses in control women showed several associations of sex hormones with breast cancer risk factors. InterpretationCirculating oestrogens and androgens are positively associated with the risk for breast cancer in premenopausal women, and may mediate some of the effects of other risk factors on breast cancer.
Primitive erythropoiesis in infantile haemangioma
Authors: T. Itinteang, S.T. Tan, H.D. Brasch, A. Vishvanath, D.J. Day
Journal: British Journal of Dermatology (2010)

BACKGROUND; Infantile haemangioma (IH) is a tumour of the microvasculature composed predominantly of proliferating endothelial cells. It expresses markers associated with endothelial, haematopoietic and mesenchymal lineages. We have previously shown that the cells forming the capillary endothelium of proliferating IH express cell surface markers and transcriptions factors consistent with it being a haemogenic endothelium.We wished to determine whether the expression of transcription factors associated with the erythroid lineage was of physiological relevance and sufficient for IH tissue cultured in vitro to undergo erythropoiesis.Immunohistochemical staining of paraffin-embedded sections of proliferating IHs was undertaken and expression of the embryonically associated haemoglobin ζ (HBZ) chain and the erythropoietin receptor (EPO-R) was determined. Relative expression of mRNA encoding these proteins was determined by quantitative reverse transcription-polymerase chain reaction using snap-frozen biopsy samples. Differentiation towards erythrocytes was investigated using freshly resected tissue cultured as explants in Matrigel.The endothelium of the microvessels, but not the pericyte layer, was strongly immunoreactive for the EPO-R and the embryonically associated HBZ chain. Abundant expression of transcripts encoding these proteins was also detected, corroborating the immunohistochemical staining. When tissue was grown in culture the cells emanating from IH explants were able to generate enucleated erythrocytes in vitro. The erythrocytes were immunoreactive for the erythrocyte-specific marker glycophorin A.The microvessels in IH are a functional haemogenic endothelium that expresses the embryonically associated HBZ chain and is able to form erythrocytes in vitro. IH thus represents a possible extramedullary site for tumour-associated primitive erythropoiesis.
276. Immunological and Metabolic Correction After Lentiviral Vector Mediated Haematopoietic Stem Cell Gene Therapy for ADA Deficiency
Authors: HB Gaspar, K Buckland, C Rivat, N Himoudi, K Gilmour, C Booth, K Cornetta, DB Kohn, D Carbonaro, A Paruzynski, M Schmidt, AJ Thrasher
Journal: Molecular Therapy (2014)
Waterborne diseases threaten industrialised countries.
Authors: Carl Kovac
Journal: BMJ (2000)

Developing countries no longer have a monopoly on waterborne diseases, according to reports presented in Budapest, Hungary, last week during a two day meeting of representatives of the signatories of the new protocol on water and health drawn up by the World Health Organization (WHO) and the United Nations Economic Commission for Europe.

It was the first gathering of the signatories since the protocol was signed by 35 countries last year in London. The …
Book ReviewRadiology of the Colon
Authors: William T. Murray
Journal: New England Journal of Medicine (1981)

In the article by Rogan et al. on pollutants in breast milk, the statement that "there are no obvious...dietary predictors" of chemical pollutants in human milk is challenged by recent unpublished data on vegetarian women. We studied 12 woman who were all members of a religious community that eliminates all animal products from the diet and uses soybeans and grains for proteins. Samples of breast milk were gathered in August 1979 and were analyzed for 17 chemical substances. The lipid levels in the vegetarian sample were similar to levels reported in the literature (mean, 4.23%, range, 1.23-7.4%). For the 7 contaminants reported for U. S. women by Rogan et al. and Savage, we compared the concentrations in the vegetarian women. For every contaminant except polychlorinated biphenyls, in which there were no strong differences between groups, there was no overlap in the range of scores; the highest vegetarian value was lower than the lowest value obtained in the U. S. sample. For beta-benzene hexachloride, dieldrin, and p,p'chlonophenothane, the 1 vegetarian subject who had more than trace amounts was the only subject who was nursing her 1st baby and had observed the vegetarian diet for less than a hear. For the other 3 substances, p,p'1,1-dichloro-2,2-bis ethylene, heptachlor epoxide, and oxychlordane, the mean vegetarian levels were only 1-2% as high as the average levels in the U. S. As Rogan et al. stated, "For certain fat-soluble chemicals, nursing infants can be regarded as living at the top of the food chain and are exposed to much more than background levels." Nursing infants of vegetarian women whose diets are low on the food chain are exposed to less chemical pollution. These preliminary results indicate that diet may indeed be a major predictor of chemical pollutants in the body. Further research is underway on a larger vegetarian sample from the same population.
Mortality of 2009 pandemic influenza A(H1N1) in Germany
Authors: H Wilking, S Buda, E von der Lippe, D Altmann, G Krause, T Eckmanns, W Haas
Journal: Eurosurveillance (2010)

The mortality in Germany caused by the 2009 pandemic influenza A(H1N1) seems to have been one of the lowest in Europe. We provide a detailed analysis of all 252 fatal cases of confirmed infection with the pandemic virus notified between 29 April 2009 and 31 March 2010. The overall mortality was 3.1 (95% confidence interval (CI): 2.7 to 3.5) per one million inhabitants. We observed an increase in the case fatality rate of notified cases over time; notified cases aged 60 years or older had the highest case fatality rate (2.16%; 95% CI: 1.61 to 2.83; odds ratio: 5.4; p<0.001; reference group: 35–59 years). The median delay of four days (interquartile range (IQR): 2–7) between symptom onset and antiviral treatment was significantly longer in fatal cases than for non-fatal cases (median: two days (IQR: 1–3; p<0.001). Analysis of the underlying medical conditions of fatal cases, based on the observed frequency of the conditions in the general population, confirms the risk for fatal outcome, which is most notably due to immunosuppression, diabetes and respiratory diseases. Our results suggest that early treatment might have had an impact on overall mortality. Identification of risk groups for targeted intervention to prevent fatalities needs to take into account the distribution of underlying conditions in the population.
Gene polymorphism in Netherton and common atopic disease
Authors: Andrew J. Walley, Stéphane Chavanas, Miriam F. Moffatt, Robert M. Esnouf, Baljinder Ubhi, Robert Lawrence, Kenny Wong, Gonçalo R Abecasis, E. Yvonne Jones, John I. Harper, Alain Hovnanian, William O.C.M. Cookson
Journal: Nature Genetics (2001)
Candidate serum biomarkers of doxorubicin-induced cardiotoxicity in pediatric acute lymphoblastic leukemia assessed by nanoparticle-capture mass spectrometry.
Authors: E. Petricoin, M. M. Ross, W. Zhou, D. Tamburro, A. Luchini, L. A. Liotta, R. E. Scully, T. L. Miller, S. E. Sallan, S. E. Lipshultz
Journal: Journal of Clinical Oncology (2010)

9528 Background: To identify low-molecular weight and abundance candidate biomarker proteins of doxorubicin cardiotoxicity in childhood ALL by innovative nanoparticle capture-mass spectrometry (MS). Comparison to elevated serum cardiac troponin T (cTnT), a validated marker of doxorubicin myocardial injury, is made. Methods: 40 sera from 14 children with ALL receiving doxorubicin were assessed: 20 were cTnT- (<0.01 ng/mL, n=8) and 20 were cTnT+, n=6. A hydrogel core-shelled nanoparticle containing acid black dye as a protein-binding agent captured, concentrated, and isolated candidate biomarker proteins from high-abundance blood proteins. High-resolution MS analyzed the nanoparticle- captured archive and identified differentially expressed serum proteins in children with detectable (+) and non-detectable (−) cTnT. Results: 226 proteins achieved a 50% difference in spectral counts between the cTnT- and cTnT+ groups. 47 proteins had significant differential expression (P<0.1) between the two groups. A more stringent statistical filtering (P< 0.007) yielded several differentially abundant proteins associated with myocardial injury. The peptide-spectra assignments from a SEQUEST search were verified manually and included three potentially differentially abundant proteins; cardiac actin, procollagen C endopeptidase enhancer, and periostin. Nanoparticle-MS is able to uncover these candidate protein biomarkers previously implicated in cardiac dysfunction, remodeling, fibrosis, and hypertrophy. Conclusions: Candidate serum biomarkers may potentially increase the predictive value of conventional markers such as cTnT for earlier detection of cardiac damage. Identifying heart-derived tissue proteins associated with myocardial injury, which can be detected before marked elevations in cTnT, would have profound implications on the earlier detection and clinical monitoring for doxorubicin cardiotoxicity before irreversible damage and loss of cardiomyocytes occurs. Additional studies evaluating the efficacy of nanoparticle-MS may advance this novel diagnostic approach to trigger cardiac evaluation and protection. Author Disclosure Employment or Leadership Position Consultant or Advisory Role Stock Ownership Honoraria Research Funding Expert Testimony Other Remuneration Ceres Nano Sciences, LLC, Theranostics Health Ceres Nano Sciences, LLC, Theranostics Health George Mason University
CHILDRENS'ASTHMA REGISTER
Authors: ANTTI KOIVIKKO
Journal: Allergy (1977)

An asthma data register which collects annually certain data from all known local asthmatic children has been presented. The data register is utilized to make a two-page print-out for every patient, and statistics of the whole material. These data make the continuous surveillance and guidance of the patients possible. The easy-to-use and accurate data material has contributed to rationalization of routine work in an asthma clinic. Team work has also improved because the uniform data material enables various workers to quickly pick out a specific problem from the whole material. The cost, $ 2 to 3 per patient per year, is low compared with the immediate benefit. Indirect benefit is to be expected because the system helps to investigate the problems of asthmatic children.
Phospholipid Metabolism in Stimulated Human Platelets
Authors: M. Johan Broekman, Jean W. Ward, Aaron J. Marcus
Journal: Journal of Clinical Investigation (1980)

Endogenous phospholipid metabolism in stimulated human platelets was studied by phosphorus assay of major and minor components following separation by two-dimensional thin-layer chromatography. This procedure obviated the use of radioactive labels. Extensive changes were found in quantities of phosphatidylinositol (PI) and phosphatidic acid (PA) as a consequence of thrombin or collagen stimulation. Thrombin addition was followed by rapid alterations in the amount of endogenous PI and PA. The decrease in PI was not precisely reciprocated by an increase in PA when thrombin was the stimulus. This apparent discrepancy could be explained by removal of a transient intermediate in PI metabolism, such as diglyceride, formed by PI-specific phospholipase C (Rittenhouse-Simmons, S., J. Clin. Invest.63: 580-587, 1979). Diglyceride would be unavailable for PA formation by diglyceride kinase, if hydrolyzed by diglyceride lipase (Bell, R. L., D. A. Kennerly, N. Stanford, and P. W. Majerus. Proc. Natl. Acad. Sci. U. S. A.76: 3238-3241, 1979) to yield arachidonate for prostaglandin endoperoxide formation. Thrombin-treated platelets also accumulated lysophospho-glycerides. Specifically, lysophosphatidyl ethanolamines accumulated within 15s following thrombin addition. Fatty acid and aldehyde analysis indicated phospholipase A(2) activity, with an apparent preference for diacyl ethanolamine phosphoglycerides. In the case of collagen, these changes occurred concomitantly with aggregation and consumption of oxygen for prostaglandin endoperoxide formation.THESE STUDIES OF ENDOGENOUS PHOSPHOLIPID METABOLISM PROVIDE INFORMATION SUPPORTING THE EXISTENCE OF TWO PREVIOUSLY POSTULATED PATHWAYS FOR LIBERATION OF ARACHIDONIC ACID FROM PLATELET PHOSPHOLIPIDS: (a) the combined action of PI-specific phospholipase C plus diglyceride lipase yielding arachidonate derived from PI; and (b) a phospholipase A(2) acting primarily on diacyl ethanolamine phosphoglyceride.