tbuckley/cabot-search huggingface dataset:
Abstract 886: Health behaviors of cancer survivors: higher alcohol drinking, lower smoking and physical inactivity pattern in survivors with higher household income
Authors: Boyoung Park, Sun-Young Kong, Jeongseon Kim, Yeol Kim, In Hae Park, So-Youn Jung, Eun Sook Lee
Journal: Cancer Research (2015)

Abstract Background: This study investigated the prevalence of smoking, alcohol consumption, and physical activity in cancer survivors and examined the sociodemographic factors affecting these health-related behaviors. Methods: We used data from the fourth and fifth Korean National Health and Nutrition Examination Survey conducted between 2007 and 2012, which identified 1,153 cancer cases and 34,368 non-cancer controls ≥ 20 years of age. We used a structured questionnaire to obtain information concerning cancer diagnosis and sociodemographic characteristics. Results: The proportion of cancer survivors who were current drinkers, heavy drinkers, current smokers, or engaged in physical activity were 49.1, 9.0, 9.2, or 50.7%, respectively. Compared with non-cancer controls, cancer survivors were less likely to be current drinkers, heavy drinkers, or current smokers (odds ratio [OR] = 0.56; 95% confidence interval [CI], 0.47-0.66; OR = 0.58; 95% CI, 0.44-0.78; and OR = 0.44, 95% CI, 0.34-0.59, respectively). Cancer survivors with higher household incomes had higher odds of current drinking and heavy drinking (P trend = 0.04 and 0.03, respectively) and were less likely to be current smokers or physically inactive (P trend &amp;lt;0.01 and 0.03, respectively). Age, gender, employment status, the type of cancer, and the duration of cancer diagnosis affected the health behaviors. Furthermore, we confirmed that these unhealthy behaviors are interrelated. Conclusions: We found that household income had a bidirectional effect on health behaviors and confirmed an aggregation of unhealthy lifestyles. Identification of survivors vulnerable to unhealthy lifestyles would allow intervention programs to be more effective. Citation Format: Boyoung Park, Sun-Young Kong, Jeongseon Kim, Yeol Kim, In Hae Park, So-Youn Jung, Eun Sook Lee. Health behaviors of cancer survivors: higher alcohol drinking, lower smoking and physical inactivity pattern in survivors with higher household income. [abstract]. In: Proceedings of the 106th Annual Meeting of the American Association for Cancer Research; 2015 Apr 18-22; Philadelphia, PA. Philadelphia (PA): AACR; Cancer Res 2015;75(15 Suppl):Abstract nr 886. doi:10.1158/1538-7445.AM2015-886
Training in general practice is also important for postregistration doctors
Authors: B. Cunningham, B. Toms, P. Harrigan, J. Turner, D. Morgan
Journal: BMJ (1995)

EDITOR,—We were encouraged to read Joe Wilton's description of the progress made in including general practice as part of the preregistration year at St Mary's Hospital Medical School.1 His results confirm that general practice provides many educational opportunities, including increased clinical activities and longer teaching times compared with those for house officers based in hospitals. It is disappointing that this is the only established preregistration rotation in England. One wonders why this valuable …
Abstract 5716: Should We Treat Hyperuricemia in Adult Patients With Cyanotic Congenital Heart Disease?
Authors: Hideshi Yamamura, Kei Inai, Tokuko Shinohara, Hirofumi Tomimatsu, Yoshiki Mori, Toshio Nakanishi
Journal: Circulation (2008)

Background: Although hyperuricemia is common, it is thought that gouty arthritis is rare in adult patients (pts) with cyanotic congenital heart disease (CCHD). However, the actual frequency of hyperuricemia and gout has not been documented. Furthermore, whether hyperuricemia should be treated remains undetermined. This study investigated the incidence of hyperuricemia and gout, risk factors for hyperuricemia and gout, and whether the use of allopurinol decreases the incidence of gout in adult patients with CCHD. Methods: We studied 92 pts with CCHD, including 19 pts with Eisenmenger syndrome (mean age: 33±11 years of age, ranging from 15 to 61), M/F = 48/44) (CCHD group). Comparative data was obtained from 210 acyanotic CHD pts after biventricular repair (mean age: 31±11 years, ranging from 15 to 83, M/F = 98/112) (ACHD group). Hyperuricemia was defined as serum uric acid (UA) &gt; 7.0mg/dl. The risk factors studied were: age, gender, RBC counts, hemoglobin, hematocrit, oxygen saturation, serum creatinine, glomerular filtration rate, cardiothoracic ratio, brain natriuretic peptide and medications, including diuretics, beta-blocker and aspirin. Results: Prevalence of hyperuricemia was 76% in the CCHD group and 24% in the ACHD group. Logistic regression analysis demonstrated that variables that significantly influence hyperuricemia were; hemoglobin over 18g/dl (odds ratio 6.2), oxygen saturation less than 90 (OR 4.8), the use of diuretics (OR 4.0), and serum creatinine higher than 1.0 mg/dl (OR 2.0). Gouty arthritis was observed in 16% in the CCHD group and only 1% in the ACHD group. The prevalence of hyperuricemia and gout in the CCHD group was significantly higher than that in the ACHD group. Of 92 pts in the CCHD group, allopurinol was administered to 37 pts for gout prophylaxis. Of 55 pts without allopurinol, 13 (24%) suffered from gout. In contrast, only 2 of 37 pts (5%) on allopurinol developed gout and the incidence was significantly lower than that in pts without allopurinol. Conclusion: These data suggest that in adult patients with CCHD, the incidence of gout is high, desaturation, polycytemia, impaired renal function, and the use of diuretics are risk factors for hyperuricemia and gout, and hyperuricemia should be treated with medication.
Early Neurodevelopmental Outcomes after Cardiac Surgery in Infancy Have Not Improved: A Multi-center Retrospective Analysis of 1,718 Patients
Authors: J. William Gaynor, Christian Stopp, David Wypij, Dean B. Andropoulos, Joseph Atallah, John Beca, Kim Duncan, Nancy S. Ghanayem, Caren S. Goldberg, Hedwig Hoevels-Gurich, Fukiko Ichida, Robert Justo, Bea Latal, William T. Mahle, Patrick McQuillen, Christian Pizarro, Lara S. Shekerdemian, Anne Synnes, David C. Bellinger, Jane W. Newburger
Journal: Circulation (2012)

Background: Neurodevelopmental (ND) disability is common in survivors of surgery for congenital heart disease (CHD). We explored whether ND outcomes following cardiac surgery in infancy have improv...
Comparison of Different TEE-Guided Thrombolytic Regimens for Prosthetic Valve Thrombosis
Authors: Mehmet Özkan, Sabahattin Gündüz, Murat Biteker, Mehmet Ali Astarcioglu, Cihan Çevik, Evren Kaynak, Mustafa Yıldız, Emrah Oğuz, Ahmet Çağrı Aykan, Emre Ertürk, Yusuf Karavelioğlu, Tayyar Gökdeniz, Hasan Kaya, Ozan Mustafa Gürsoy, Beytullah Çakal, Süleyman Karakoyun, Nilüfer Duran, Nihal Özdemir
Journal: JACC. Cardiovascular imaging (2013)
Gastric metaplasia should be considered too
Authors: F. I Tovey
Journal: BMJ (1995)

agents in minimal change nephropathy is contro- versial.This implies that the benefits are unproved, whereas a definite, sustained effect has been shown in controlled trials.3There are, however, side effects associated with these agents, and the authors are correct in stating that their use should be carefully considered.The consensus statement lists two clear indications for second line treatment.(1) Relapse while taking prednisolone > 0 5 mg/kg on alternate days plus one or more of (a) unaccept- able side effects of corticosteroid treatment; (b) high risk of steroid toxicity-for example, in boys approaching puberty or in diabetes; (c) unusually severe relapses (hypovolaemia or thrombosis); and (ad) inadequate facilities for follow up or concern about compliance.(2) Relapse while taking prednisolone > 1 mg/kg on alternate days.The recommended dose of cyclophos- phamide is 3 mg/kg/day for eight weeks.The report describing fewer relapses in children treated with cyclophosphamide for 12 weeks was limited to patients with steroid dependent disease.4
P0091 : N-acetylcysteine modulates angiogenesis, vasodilation and dna damage in stomach of portal hypertensive rats
Authors: N.P. Marroni, F. Licks, R. Hartmann, C. Marques, E. Schemitt, M. Soares, J. Reys, C. Fisher, J. da Silva
Journal: Journal of Hepatology (2015)
Functional genomic approach to identify novel genes involved in regulation of IGF-I and mTOR signaling pathways
Authors: Hong Sun, Yongsoon Kim, Papia Ghosh
Journal: Clinical Cancer Research (2007)

AACR Centennial Conference: Translational Cancer Medicine-- Nov 4-8, 2007; Singapore

C60 

The IGF-I and mTOR signaling pathways are intimately involved in human cancers. These signaling pathways are also highly conserved evolutionally. We have used C. elegans, a genetically amenable system, to identify novel genes involved in these pathways. In C. elegans, loss-of-function mutations in the genes encoding DAF-2 (the insulin/IGF-I-receptor like molecule) and AGE-1 (the PI 3-kinase homolog), respectively, lead to dramatic increase of resistance towards ROS (reactive-oxygen species) and enhancement of animal lifespan. Consistently, null mutations in the daf-18 gene, which encodes the C. elegans homolog of PTEN tumor suppressor, cause sensitivity towards ROS and shorten animal lifespan. We have carried out functional genomic screens using RNAi to identify novel genes involved in regulation of ROS resistance and animal lifespan. In our primary screen, we screened for RNAi clones that could confer resistance towards paraquat, a ROS generating agent. The positive clones were then screen for ability to extend animal lifespan (secondary screen). To this date, we have screened one-third of the C. elegans genome to completion and identified 84 genes that are positive in these two sequential assays. Most of the genes identified are novel for their function in regulation of ROS resistance and animal lifespan. By genetic interaction tests, we have found that 29 of these genes potentially encode novel regulators of the DAF-2/insulin-receptor like signaling pathway. Our subsequent biochemical studies in mammalian cells have confirmed that some of their human homologs indeed function in the IGF-I (insulin-like growth factor I) signaling pathway. In addition, we have identified several genes that encode proteins likely function in the TOR (target-of-rapamycin) signaling pathway. Studying the functions of these genes may help to elucidate the mechanisms by which the TOR pathway is activated by a variety of stimuli. Our studies illustrate the power of functional genomic approach in identifying novel players in these important signaling pathways. These new molecules may serve as targets for developing anti-cancer chemotherapies.
Abstract 4909: Usefulness of Stent Boost Enhancement for Stent Expansion During Coronary Angioplasty in Daily Practice
Authors: Alice Ohanessian, Sanjay Sastry, Nabil Bendaoud, Thierry Lefevre, Thomas Hovasse, Yves Louvard, Marie-Claude Morice
Journal: Circulation (2008)

Background:  Adequate stent expansion plays a major part in the occurrence of thrombosis and restenosis in patients undergoing PCI. X-ray assessment of correct stent deployment can be difficult due to poor visualization of the stent structure and to rapid stent movement. The gold standard evaluation method is IVUS, but routine use is costly and time-consuming. Stent boost is a new technique improving fluoroscopy-based assessment of stent expansion. The purpose of the study was to assess the usefulness and impact of stent boost in routine practice.   Methods : StentBoost  ™  (SB ™ ) is a software developed by Philips. A short digital cine run is acquired with a deflated balloon in place. The software averages selected frames (centred on the stent) and creates an enhanced image improving signal-to-noise ratio. A total of 230 consecutive patients were prospectively included, (mean age : 6711years) and 278 coronary stents (mean size 18.85±6.5 2.96±0.48 mm) analyzed. Stent visibility was assessed using both standard angio and SB ™  and graded from 1 to 4 (1= poor, 2= average, 3= good, 4= excellent). The need for post dilatation was evaluated (0= well deployed stent, post dilatation not required; 1= inadequately deployed stent, post dilatation not performed; 2 = inadequately deployed stent, post dilatation performed). The usefulness of SB ™  compared with conventional angio images was graded: 0= not needed in the presence of sufficient angio data, 1= SB™ useful compared to angio data.   Results : Visualization of adequate stent expansion was improved by the use of the stent boost system. Angiographic stent visibility was: 1= 26%, 2= 46%, 3= 26, 4= 2%; with a mean of 2.03±0.76. SB  ™  visibility was 1= 11%; 2= 20%; 3= 54%,4= 15%with a mean of 2.76±0.94. The use of SB™ after each stent implantation was deemed useful in 72% of cases. Post dilation after stent implantation was performed in 31% of cases.   Conclusion:  Post angioplasty assessment of adequate stent expansion, by means of the stent boost system was deemed useful in a large majority of cases. This user-friendly system does not increase procedure duration and may decrease the risk of stent thrombosis.
Abstract #5375: Streptavidin conjugated quantum dots for multiplex detection of cancer-related biomarker
Authors: Rami Yacoub, Seema Harichand-Herdt, Vaunita Cohen, Roberd Bostick, Ruth O'Regan
Journal: Cancer Research (2009)

AACR Annual Meeting-- Apr 18-22, 2009; Denver, CO

Introduction: Identification of biomarkers in cancers requires multiplex simultaneous profiling of cancer cells or tumor tissue, along with accurate measurements of their expression levels. Immunohistochemistry (IHC) is currently one of the most common detection methods in pathology for clinical diagnoses. However, it remains semi-quantitative, subjective with considerable inter-observer variation, and with no ability to detect multiple targets on a single sample of tissue. Semiconductor nanocrystals, also known as quantum dots (QDs), represent a new class of fluorescent labels with unique optical properties and the potential to overcome limitations of traditional IHC techniques. We have used streptavidin-conjugated quantum dots (SA-QD) in a QD based-IHC assay. This method helps to address the two major deficiencies of antibody-based labeling QD: the limited availability of species-specific secondary antibodies, the size of the QD conjugate after antibody attachment, and the instability of many antibody-antigen interactions which lead in these cases to dissociation of the antibody-conjugated QD from the protein of interest. Biotin detection by streptavidin has numerous advantages. It is one of the tightest interactions known ( K d = 10-13 M), with an off-rate on the order of days. In addition, streptavidin displays little nonspecific binding and is significantly smaller than an IgG antibody (60 versus 150 kDa), and a large number of streptavidin conjugates are commercially available. Methods: We evaluated the use of SA-QD with distinct emission spectra to \#8220;stain\#8221; formalin-fixed, paraffin-embedded (FFPE) breast cancer, normal colon, and tonsil tissues using a panel of primary antibodies targeting known biomarkers. Standard IHC controls were used for comparison and validation of our QD-IHC protocol. Most, but not all, antibody and quantum dot combinations worked with equal efficacy. The stains were performed by layering each antibody and QD in a sequential fashion. Results: Staining of two, three, and four antigens per slide was accomplished successfully on FFPE tonsil, breast tumor and normal colon tissues. QD-IHC processed tissues were imaged and analyzed using confocal laser scanning microscopy (LSM510 META from Zeiss). The use of streptavidin QDs for multiplex detection of tumor antigens offers a viable method of detecting and quantifying multiple cancer-related antigens simultaneously. We are continuing to optimize this technology and updated images and analyses will be presented.

Citation Information: In: Proc Am Assoc Cancer Res; 2009 Apr 18-22; Denver, CO. Philadelphia (PA): AACR; 2009. Abstract nr 5375.
PRIMARY SARCOMA OF THE INTESTINE.
Authors: F D Ackman
Journal: JAMA (1900)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
New Appliances
Authors: C SANDERS
Journal: BMJ (1959)

PLENARY SESSIONSBDl 299 which had so far been shown to be responsible for many cases of Hashimoto's disease, myxoedema, and lupoid hepatitis.It was very possible that here lay the explanation of the causes of collagen disorders.Lord Cohen concluded by pointing out the dangers of a too ready acceptance of "collagen diseases" as a convenient label for the diagnostically destitute: the use of facile labels for clinical conditions was wrong and degrading.
Abstract 3266: Detection Of Patent Foramen Ovale By Transesophageal Echocardiography and Contrast-Enhanced Cardiac Magnetic Resonance In Patients With Cryptogenic Stroke.
Authors: Alfonso Sestito, Pasquale Santangeli, Priscilla Lamendola, Fabio Pilato, Christian Colizzi, Luigi Natale, Vincenzo Di Lazzaro, Gaetano A Lanza, Filippo Crea
Journal: Circulation (2007)

Background. In ≈ 40% of patients with acute ischemic stroke, the cause remains undefined (cryptogenic stroke). Previous studies, using contrast echocardiography, showed a significant prevalence of a patent foramen ovale (PFO) in patients with cryptogenic stroke &lt; 55 years of age, suggesting a causal role through paradoxical embolism. Contrast transesophageal echocardiography (TEE) is considered the gold standard for PFO detection. Recently, however, cardiac magnetic resonance (CMR) was also shown to reliably detect PFO. In this study we compared the accuracy of CMR and TEE in detecting PFO in a group of patients with cryptogenic stroke. Methods and Results . Sixteen patients (age 50 ± 13 years, 9 males) with cryptogenic ischemic stroke underwent contrast-enhanced TEE and contrast CMR for detection of possible PFO. Both imaging studies were performed during Valsalva maneuver. PFO grading results were assessed visually both for TEE and CMR, according to the entity of contrast passage in the left atrium (grade 0 = no PFO; grades 1, 2 and 3 = mild, medium and wide PFO, respectively). Nine patients (56%) were identified to have a PFO by contrast TEE. Contrast-enhanced CMR identified a PFO in only 5 (56%) of these patients. None of the 7 patients without PFO at TEE was shown to have a PFO at CMR. TEE showed a grade 1 PFO in 4 patients, a grade 2 PFO in 3 and a grade 3 PFO in 2 patients. Of these patients, CMR failed to identify PFO in all patients with a grade 1 PFO at TEE and underestimated the degree of the shunt in the other patients. Conclusions. Our data suggest that TEE should be considered the non-invasive diagnostic reference test to detect and characterize PFO in patients with ischemic cryptogenic stroke.
Inappropriate Implantable Cardioverter-Defibrillator Shocks in MADIT II
Authors: James P. Daubert, Wojciech Zareba, David S. Cannom, Scott McNitt, Spencer Z. Rosero, Paul Wang, Claudio Schuger, Jonathan S. Steinberg, Steven L. Higgins, David J. Wilber, Helmut Klein, Mark L. Andrews, W. Jackson Hall, Arthur J. Moss
Journal: Journal of the American College of Cardiology (2008)
Abstract 2324: Comparison of Gold and Platinum Electrodes for Saline Irrigated Radiofrequency Ablation
Authors: Atsushi Ikeda, Hiroshi Nakagawa, Jan V Pitha, Tushar Sharma, Ralph Lazzara, Karl-Heinz Kuck, Warren M Jackman
Journal: Circulation (2009)

Introduction: Compared to platinum, gold has 4 times greater thermal conductivity. We hypothesized that a gold irrigated ablation electrode can provide additional electrode cooling during saline-ir...
Copper Intrauterine Devices and Tubal Infertility among Nulligravid Women
Authors: Martin P Vessey, Helen A Doll
Journal: New England Journal of Medicine (2002)

Vessey and Doll state that long-term use of copper IUDs may impair fertility. We disagree that our case-control study did not include enough long-term use of the IUD to show this putative effect. (excerpt)
Four-Year Efficacy of Cardiac Resynchronization Therapy on Exercise Tolerance and Disease Progression
Authors: Maurizio Gasparini, Angelo Auricchio, François Regoli, Cecilia Fantoni, Mihoko Kawabata, Paola Galimberti, Daniela Pini, Carlo Ceriotti, Edoardo Gronda, Catherine Klersy, Simona Fratini, Helmut H. Klein
Journal: Journal of the American College of Cardiology (2006)
Abstract 5: Multicenter Characterization Of Rescuer Fatigue During In-hospital Cardiopulmonary Resuscitation
Authors: Noah T Sugerman, Elizabeth K Weidman, Dana P Edelson, Marion Leary, Terry L Vanden Hoek, Lance B Becker, Benjamin S Abella
Journal: Circulation (2008)

Background: The delivery of high quality chest compressions (CC) is a crucial component of resuscitation from cardiac arrest. Rescuer fatigue has been hypothesized to adversely affect CC quality. P...
Abstract 1558: Changes in Markers of Systemic Inflammation Predict Progression of Coronary Atherosclerosis in Patients With Abdominal Obesity
Authors: Ajai Shreevatsa, Stephen J Nicholls, Kathy Wolski, Ozgur Bayturan, Andrea Lavoie, Kiyoko Uno, Jean-Pierre Despres, John Deanfield, John K Kastelein, Christopher P Cannon, Bernard Job, Christophe Gaudin, E M Tuzcu, Steve E Nissen
Journal: Circulation (2009)

Background: The endocannabinoid receptor antagonist rimonabant was shown to not slow progression of percent atheroma volume (PAV) in abdominally obese patients with coronary artery disease. The imp...
Ketoconazole administration in hypercortisolemic depression
Authors: O M Wolkowitz, V I Reus, F Manfredi, J Ingbar, L Brizendine, H Weingartner
Journal: American Journal of Psychiatry (1993)

Ketoconazole, an antiglucocorticoid drug, was administered to 10 hypercortisolemic depressed patients for up to 6 weeks. Three patients dropped out because of side effects or intercurrent illness. The remaining seven had significant ketoconazole-associated decreases in serum cortisol levels and in depression ratings. Antiglucocorticoid agents may be useful probes for investigating the sequelae of hypercortisolemia in patients with major depression.