tbuckley/cabot-search huggingface dataset:
Effects of MIP-1α, MIP-3α, and MIP-3β on the Induction of HIV Gag-specific Immune Response with DNA Vaccines
Authors: Ruijiang Song, Shuqin Liu, Kam W Leong
Journal: Molecular Therapy (2007)

Transfection of DNA vaccines with chemokines may recruit dendritic cells (DCs) locally to capture the antigenic genes and their gene products to generate enhanced CD8+ cytotoxic T lymphocytes (CTLs). In this study, we investigated the effects of macrophage inflammatory protein (MIP)-1α, MIP-3α, and MIP-3β on human immunodeficiency virus (HIV) Gag DNA vaccination. The chemokine plasmids markedly enhanced the local infiltration of inflammatory cells and increased the presence of CD11c+ B7.2+-activated DCs. MIP-1α and MIP-3α were potent adjuvants in augmenting CTLs and afforded strong protection to immunized animals against challenge with vaccinia virus expressing Gag (vv-Gag). However, decreased humoral response was observed. MIP-3β plasmid did not dramatically alter immunity. The chemokine inoculation time with respect to DNA vaccine priming was also investigated. The injection of pMIP-3α three days before Gag plasmid (pGag) vaccination markedly increased specific CTLs compared with simultaneous injection and led to higher protection against vv-Gag. Immunity was also shifted toward a T-helper type-1 (Th1) response. In contrast, inoculation with pMIP-3α three days after pGag vaccination shifted immunity toward a Th2 response. Our data suggest that administration of a chemokine with DNA vaccines offers a valuable strategy to modulate the efficacy and polarization of specific immunity and that chemokine–antigen timing is critical in determining overall biological effects. Transfection of DNA vaccines with chemokines may recruit dendritic cells (DCs) locally to capture the antigenic genes and their gene products to generate enhanced CD8+ cytotoxic T lymphocytes (CTLs). In this study, we investigated the effects of macrophage inflammatory protein (MIP)-1α, MIP-3α, and MIP-3β on human immunodeficiency virus (HIV) Gag DNA vaccination. The chemokine plasmids markedly enhanced the local infiltration of inflammatory cells and increased the presence of CD11c+ B7.2+-activated DCs. MIP-1α and MIP-3α were potent adjuvants in augmenting CTLs and afforded strong protection to immunized animals against challenge with vaccinia virus expressing Gag (vv-Gag). However, decreased humoral response was observed. MIP-3β plasmid did not dramatically alter immunity. The chemokine inoculation time with respect to DNA vaccine priming was also investigated. The injection of pMIP-3α three days before Gag plasmid (pGag) vaccination markedly increased specific CTLs compared with simultaneous injection and led to higher protection against vv-Gag. Immunity was also shifted toward a T-helper type-1 (Th1) response. In contrast, inoculation with pMIP-3α three days after pGag vaccination shifted immunity toward a Th2 response. Our data suggest that administration of a chemokine with DNA vaccines offers a valuable strategy to modulate the efficacy and polarization of specific immunity and that chemokine–antigen timing is critical in determining overall biological effects.
MENINGOCOCCI MENINGITIS—SULFADIAZINE THERAPY (REVIEW OF TWENTY CASES)
Authors: Emil H. Grieco, Arthur M. Cove
Journal: Annals of Internal Medicine (1944)

Article1 August 1944MENINGOCOCCI MENINGITIS—SULFADIAZINE THERAPY (REVIEW OF TWENTY CASES)EMIL H. GRIECO, ARTHUR M. COVEEMIL H. GRIECOSearch for more papers by this author, ARTHUR M. COVESearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-21-2-194 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptINTRODUCTIONAn increased occurrence of all types of contagious diseases may be anticipated incidental to the mobilization of large groups of men. During the year 1941, no cases of epidemic meningitis were seen in this institution, whereas from June 1942 through June 1943, 20 cases of this disease were treated here (Station Hospital, Fort Totten, New York). These cases were sporadic throughout the metropolitan area. Their scatter precluded epidemic consideration. No direct contact had been established between any two of this group of patients. Routine pharyngeal cultures of the men comprising the groups from which these cases had been isolated...Bibliography1. KANTOR HI: Sulfapyridine in meningococcus meningitis: review of the literature and report of a case, New York State Jr. Med., 1940, xl, 1526. Google Scholar2. MAIER C: Specific treatment of epidemic meningitis with sulfanilamide derivatives (Dagenan and "Ciba 3714"), Schweiz. med. Wchnschr., 1940, lxx, 879. Google Scholar3. DINGLETHOMASMORTON JHLAR: Treatment of meningococcic meningitis and meningococcemia with sulfadiazine, Jr. Am. Med. Assoc., 1941, cxvi, 2666. CrossrefGoogle Scholar4. GERNEZHURIEZ CC: Considerations on the sulfamide treatment of the meningococcic cerebrospinal meningitis, La presse med., 1941, xlix, 25. Google Scholar5. FELDMANSWEETDOWLING HALKHF: Sulfadiazine therapy of purulent meningitis, including its use in twenty-four consecutive patients with meningococcic meningitis, War Med., 1942, ii, 995. Google Scholar6. HARRIES GE: Cerebrospinal fever. A review of 500 cases treated by chemotherapy without intrathecal serum, Brit. Med. Jr., 1942, ii, 433. Google Scholar7. S.G.O. Circular Letter No. 17, February 23, 1942, Chemotherapy in infectious diseases and other infections. Google Scholar8. ZINSSER H: Textbook of bacteriology, 5th edition, 1925. Google Scholar9. GOODMANGILMAN LA: The pharmacological basis of therapeutics, 1941, Macmillan Company, New York. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: *Received for publication November 1, 1943.†The authors wish to express their appreciation to Colonel A. J. Vadala, M. C., for his kind assistance in the preparation of this paper. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited bySulfonamideSulfonamide 1 August 1944Volume 21, Issue 2Page: 194-199KeywordsMeningitis ePublished: 1 December 2008 Issue Published: 1 August 1944 PDF downloadLoading ...
Basal Cell and Squamous Cell Carcinoma in Persons Younger Than 40 Years
Authors: Chad T. Wilson
Journal: JAMA (2006)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Medical School Curricula in Spirituality and Medicine
Authors: A. H. Fortin
Journal: JAMA (2004)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Early mortality and the retinoic acid syndrome in acute promyelocytic leukemia: impact of leukocytosis, low-dose chemotherapy, PMN/RAR-alpha isoform, and CD13 expression in patients treated with all-trans retinoic acid
Authors: L Vahdat, P Maslak, WH Jr Miller, A Eardley, G Heller, DA Scheinberg, RP Jr Warrell
Journal: Blood (1994)
Downstream Complications of Total Parenteral Nutrition—The Domino Effect
Authors: Sarah M. Kuhn, Ruchi Jain, Kristi M. Moore
Journal: JAMA Internal Medicine (2015)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Internal Medicine HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Internal Medicine journal
Abstract 17887: Characteristics of Specific Heart Imaging in Survivors of Ventricular Fibrillation by 320 Slice CT
Authors: Nobusada Funabashi, Masae Uehara, Issei Komuro
Journal: Circulation (2010)

Purpose: To evaluate the characteristics of specific heart images in survivors of ventricular fibrillation (VF) by 320 slice CT. Materials and Methods: 28 consecutive de novo survivors of VF (22 males, 64±24 yrs), referred to our institute who all had implantable cardioverter defibrillators underwent enhanced retrospective ECG gated conventional 320 slice CT (Aquilion one). Images were reconstructed every 5% from 0–95% of the R-R interval and 4 dimensional images were also reconstructed for evaluation of cardiac motion. If there were contrast defects in left ventricular (LV) myocardium (LVM) in early phase, late phase acquisition was added to evaluate abnormal late enhancement (LE), suggesting presence of fibrosis or inflammation. Result: 17 subjects (61%) revealed normal coronary arteries and no organized heart diseases. Three (11%) had abnormal coronary arteries: 1 had significant luminal stenosis in left anterior descending branch, 1 had giant right coronary arterial aneurysm due to coronary LV fistula...
Abstract 4149: Under-expansions of Drug Eluting Stents in Patients With Acute Coronary Syndrome Are Associated With Plaque Components as Well as Vessel Size or Plaque Burden
Authors: Wang-Soo Lee, Sang-Wook Kim, Kwang-Je Lee, Tae-Ho Kim, Chee-Jeong Kim, Wang-Seong Ryu
Journal: Circulation (2009)

Background: The under-expansions after coronary stenting, especially in patients with acute coronary syndrome (ACS), are associated with post stenting cardiac events such as stent thrombosis. Howev...
EVALUATION OF THE LIVER BIOPSY
Authors: Philip G. Keil, S. N. Landis, Kenneth R. Cross, Thomas E. Corcoran
Journal: Annals of Internal Medicine (1952)

Article1 May 1952EVALUATION OF THE LIVER BIOPSYPHILIP G. KEIL, S. N. LANDIS, KENNETH R. CROSS, M.D., THOMAS E. CORCORAN, M.D.PHILIP G. KEILSearch for more papers by this author, S. N. LANDISSearch for more papers by this author, KENNETH R. CROSS, M.D.Search for more papers by this author, THOMAS E. CORCORAN, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-36-5-1278 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptDirect inspection of the liver is desirable in suspected hepatic disease.1, 2, 3, 4 The purpose of this paper is to present a comparison of gross impression and histologic diagnosis. A series of normal and diseased livers was examined peritoneoscopically. Biopsies were obtained under direct vision, using needle and forceps technics. We also wish to present our opinion as to the comparative adequacy of needle and forceps biopsies.There are many detailed clinical studies of hepatic disease based on liver function tests and biopsy.5, 6Disagreement exists regarding correlation of liver function tests with structure. This disagreement is generally acknowledged....Bibliography1. Ruddock JC: Peritoneoscopy, West. J. Surg. 42: 392-405 (July) 1934. Google Scholar2. Ruddock JC: Peritoneoscopy, South. Surgeon 8: 113-135 (April) 1939. Google Scholar3. Ruddock JC: The application and evaluation of peritoneoscopy, California Med. 71: 110-116 (Aug.) 1949. MedlineGoogle Scholar4. KeilLandis PGSN: Peritoneoscopy, J. Iowa M. Soc. 41: 48-50 (Feb.) 1951. MedlineGoogle Scholar5. PopperSteigmannMeyerKozellFranklin NFKADDM: Correlation of liver function and liver structure, Am. J. Med. 6: 278-291 (March) 1949. CrossrefMedlineGoogle Scholar6. KinsellWeissMichaelsShaverBarton LWHAGDJSHC: The correlation of hepatic structure and function, Am. J. Med. 6: 292-307 (March) 1949. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: *Received for publication October 22, 1951.From the Departments of Medicine and Pathology, Veterans Administration Hospital, Des Moines, Iowa.Sponsored by the Veterans Administration with the approval of the Chief Medical Director. Statements and conclusions by the authors are a result of their own study and do not necessarily reflect the opinion or policy of the Veterans Administration. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byDie „persistierende Hepatitis“ im Vergleich mit den anderen chronischen Verlaufsformen nach epidemischer VirushepatitisPeritoneoscopy—A RevaluationEndoscopyNeedle biopsy of the liver. A diagnostic aid in the treatment of cancer 1 May 1952Volume 36, Issue 5Page: 1278-1284KeywordsBiopsyHospital medicineLiverLiver diseasesLiver function testsVision ePublished: 1 December 2008 Issue Published: 1 May 1952 PDF downloadLoading ...
Abstract 64: Echocardiographic Determinants of Change in Cardiorespiratory Fitness in Response to Exercise Training: The DREW Study
Authors: Ambarish Pandey, Colby Ayers, Steven N Blair, Timothy S Church, Damon L Swift, Conrad P Earnest, Jarett D Berry
Journal: Circulation (2014)

Background: Although exercise training is associated with an improvement in cardiorespiratory fitness (CRF), there is substantial individual heterogeneity in the response to exercise training. To our knowledge, the contribution of baseline left ventricular structure to the variability in exercise training response has not been studied. Methods: We included 147 subjects from the Dose Response to Exercise in Women (DREW) study cohort who were randomized to 4, 8, 12 kilocalories/kg/week of aerobic training for 6 months and had a baseline transthoracic echocardiogram. CRF was evaluated at baseline and 6 month follow up using a cycle ergometer and quantified as peak absolute oxygen consumption (VO2abs L O2/min) and peak relative oxygen consumption (mLO2/kg/min). Change in CRF was defined as the difference in VO2abs between the two examinations. Baseline demographic, clinical and echocardiographic characteristics were compared among subjects across tertiles of CRF change. Multivariable adjusted linear regression analysis was used to determine the association between echocardiographic measures at baseline and the change in CRF in response to exercise training. Results: Participants were middle age (mean age: 57), obese (mean BMI: 31), and with low baseline CRF (average METs: 4.3). As expected, lower baseline CRF and a higher exercise training dose were associated with a greater increase in CRF. In addition, posterior wall thickness (PWT), interventricular septal thickness (IVST), and indexed left ventricular mass (LVmi) were all found to be inversely associated with change in CRF in response to exercise training after adjustment for age, body mass index, baseline CRF, blood pressure and exercise training dose (see Table). Other echocardiographic measures (i.e. systolic and diastolic function) were not associated with change in CRF. Conclusions: Both left ventricular mass and wall thickness are independent predictors of CRF change in response to exercise training among obese, sedentary postmenopausal females.
The consequences of gestational intermittent hypoxia on new born mice
Authors: Jennifer Truchot, Thomas Bourgeois, Maud Ringot, Boris Matrot, Jorge Gallego, Marie Pia D. Ortho
Journal: European Respiratory Journal (2014)

Introduction: Obstructive sleep apnea (OSA) is a major public health issue because of its prevalence and morbidity. Pregnancy is associated with a high prevalence of OSA. However, the consequences of gestational OSA are poorly known. We hypothesized that intermittent hypoxia (IH), an hallmark of OSA, induces prenatal and neurodevelopmental abnormalities of cardiorespiratory and cognitive functions. Theses anomalies could be related to a systemic and tissue inflammation.  Methods: A classic model of IH was applied to pregnant mice using 5% FiO2, 30 cycles /h 10 hours a day, during the last 10 days of gestation. The IH model was characterized by monitoring transcutaneous oxygen saturation and the mothers9 weight. The pups9 evaluation consisted of daily weighing, measuring cardio respiratory parameters at basal state and during hypoxic and hypercapnic challenges at 5 and 12 days of age. Cognitive functions were evaluated by the object recognition test (ORT) at 60 days of age. Cytokine assay was performed in serum and tissue samples (Merck Millipore, Magpmag-24k -Billerica, Massachusetts).  Results: The IH induced oxygen desaturations and delayed weight gain in pregnant mice without showing serum and tissue inflammation. The study of IH exposed pups revealed: 1 / transient respiratory anomalies such as an increase in basal normoxic ventilation (Ve, Ttot), 2 / a persistent growth retardation at all postnatal ages till 30 days and 3 / no differences in cognitive function evaluated by the ORT.  Discussion: These results are consistent with the current literature and suggest an impact of IH. The prospects inspired by our work are the study of the consequences of a less severe IH model, closer to human pathology.
T-cell and T/natural killer-cell lymphomas involving ocular and ocular adnexal tissues
Authors: Sarah E Coupland, Hans-Dieter Foss, Chalid Assaf, Claudia Auw-Haedrich, Gerassimos Anastassiou, Ioannis Anagnostopoulos, Michael Hummel, James W Karesh, William R Lee, Harald Stein
Journal: Ophthalmology (1999)
A20-mediated RIP ubiquitination in glioblastoma resistance to TRAIL treatment
Authors: Anita Bellail, Margaret Tse, Chunhai Hao
Journal: Cancer Research (2007)

1596  Background: TRAIL (Tumor necrosis factor-related apoptosis-inducing ligand) has emerged as a novel cancer therapeutic agent because it selectively induces apoptosis in human cancer cells. However, the vast majority of human glioblastoma cells are TRAIL-resistant. Further more, we have shown that RIP (receptor-interacting protein) plays a crucial role in the TRAIL resistance. Here, we further report the role of A20-mediated RIP ubiquitination in the TRAIL resistance in human glioblastomas.  Methods and Results: TRAIL interacts with cell surface death receptors DR4/5, leading to the assembly of death-inducing signal complex (DISC), where caspase-8 is activated and thus initiates intracellular apoptotic signal. The DISC was isolated from human glioblastoma cells by treating the cells with mixed Flag-TRAIL and anti-Flag M2 antibody, followed by immunoprecipitation with anti-M2 antibody agarose. Western blots detected RIP and A20 in the DISC in TRAIL-resistant but not sensitive glioblastoma cells. The DISC was further treated with SDS buffer to dissociate the proteins in the complex; RIP was then immunoprecipitated; and Western blots detected the higher molecular weight ubiquitin-conjugated RIP proteins in the DISC. As the controls, the cells were lysed and then immunoprecipitated with mixed Flag-TRAIL/M2 antibody and agarose. Intriguingly, Western blot analysis revealed an unstimulated complex formed by DR4/5, RIP and A20 prior to TRAIL treatment. The complex was treated with SDS buffer; RIP was then immunoprecipitated from the complex; and Western blots failed to detect the higher molecular weight ubiquitin-conjugated RIP. Further examination showed the recruitment of IKK-γ (inhibitor of κB or NEMO) to the DISC and subsequent activation of NF-κB (nuclear factor-κB) in TRAIL-resistant glioblatoma cells. These results indicate that DR4/5, RIP and A20 form a complex prior to TRAIL treatment and this complex mediates TRAIL-induced RIP ubiquitination and NF-κB activation in TRAIL resistant glioblastoma cells. Examination by RT-PCR and Western blots demonstrated that A20 was highly expressed in the majority of human glioblastoma tumors (7/10 samples) as compared to normal human brain tissues. Conclusion: This study indicates that A20 is highly expressed in the majority of human glioblatomas. A20 forms an unstimulated complex with DR4/5 and RIP and mediates TRAIL-induced RIP ubiquitination in TRAIL resistance. Targeting of A20-mediated RIP ubiquitination pathway may provide a novel therapeutic approach that can overcome the TRAIL resistance in human glioblastomas.