tbuckley/cabot-search huggingface dataset:
Abstract 2573: The immunocytokine NHS-IL12 as a potential cancer therapeutic
Authors: Jonathan K. Fallon, Robert Tighe, Amanda J. Lyon, Helen Sabzevari, Jeffrey Schlom, John W. Greiner
Journal: Cancer Research (2014)

Abstract Targeted delivery of IL-12 might make this cytokine a safer, more effective cancer therapeutic. Here we evaluated whether fusing IL-12 to a tumor necrosis-targeting human IgG1 (NHS76) could improve its anti-tumor efficacy in vivo. In vivo imaging and immunohistochemistry staining were used to assess the ability of this novel immunocytokine (NHS-IL12) to target murine tumors. The anti-tumor efficacy of NHS-IL12 was examined at various doses and treatment schedules. Immune cell subset-depleting antibodies, flow cytometric methods, and in vitro cytotoxicity and ELISA assays were used to investigate the mechanisms of action of NHS-IL12. This immunocytokine was investigated in several models and in all cases NHS-IL12 outperformed recombinant IL-12 in anti-tumor activity. Depletion of immune cell subsets revealed that the anti-tumor activity depends primarily on CD8+ cells; mice that had complete tumor regression following NHS-IL12 treatment displayed durable anti-tumor memory responses. Combining NHS-IL12 treatment with a cancer vaccine, radiation, or chemotherapy resulted in greater anti-tumor effects than each individual therapy alone. These preclinical findings provide a rationale for the clinical testing of this immunocytokine, both as a single agent and in combination with vaccines, radiation, and chemotherapy. NHS-IL12 is currently being evaluated in a Phase 1 clinical trial (NCT01417546). Citation Format: Jonathan K. Fallon, Robert Tighe, Amanda J. Lyon, Helen Sabzevari, Jeffrey Schlom, John W. Greiner. The immunocytokine NHS-IL12 as a potential cancer therapeutic. [abstract]. In: Proceedings of the 105th Annual Meeting of the American Association for Cancer Research; 2014 Apr 5-9; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2014;74(19 Suppl):Abstract nr 2573. doi:10.1158/1538-7445.AM2014-2573
Abstract 817: Sepantronium is a DNA damaging agent that potentiates PLK1 inhibitor volasertib
Authors: Mei Hong, Mingqiang Ren, Jeane Silva, Zhonglin Hao
Journal: Cancer Research (2014)

Abstract In a search for novel agents that boost the anti-neoplastic effects of polo-like kinase 1(PLK1) inhibitor volasertib, we found that a sepantronium and volasertib combination at the nano mole concentration potently inhibited growth of various non-small cell lung cancer (NSCLC) cell lines than either drug alone in vitro. Combination use of volasertib with sepantronium inhibited adaptation of cells to polo arrest. Addition of sepantronium to volasertib prevented accumulation of survivin and cyclin B protein at a concentration causing no appreciable survivin down regulation. Sepantronium, was originally developed as a survivin inhibitor. However, sepantronium induced cell cycle arrest from G1 or G2/M phase. Further studies demonstrated DNA damage of cancer cells when they are treated with sepantronium, which is evidenced by induction of phospho-gammaH2AX. In line with induction of a DNA damage response in cancer cells, known DNA damage response sensors and transducers ATM, ATR, CHK1, CHK2, p53 are phosphorylated following drug treatment. Meanwhile, expression of CDKN1A, BAX and XRCC5 are induced at the mRNA level as determined by quantitative real time PCR. A single cell electrophoresis assay (Comet assay) of cells treated with sepantronium revealed severe DNA strand breaks. M-phase arrest does not increase the lethality of DNA damage by sepantronium as compared to G1 phase arrest. Knock down of survivin did not cause DNA damage. Hence, sepantronium is a DNA damaging agent that synergizes with volasertib and down- regulation of survivin is likely the consequence of DNA damage induced by sepantronium. Citation Format: Mei Hong, Mingqiang Ren, Jeane Silva, Zhonglin Hao. Sepantronium is a DNA damaging agent that potentiates PLK1 inhibitor volasertib. [abstract]. In: Proceedings of the 105th Annual Meeting of the American Association for Cancer Research; 2014 Apr 5-9; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2014;74(19 Suppl):Abstract nr 817. doi:10.1158/1538-7445.AM2014-817
Drinking Water Safety
Authors: Rebecca Voelker
Journal: JAMA (1999)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Eczema severity in preadolescent children and its relation to sex, filaggrin mutations, asthma, rhinitis, aggravating factors and topical treatment: a report from the BAMSE birth cohort
Authors: N. Ballardini, I. Kull, C. Söderhäll, G. Lilja, M. Wickman, C.F. Wahlgren
Journal: British Journal of Dermatology (2013)

Journal Article Eczema severity in preadolescent children and its relation to sex, filaggrin mutations, asthma, rhinitis, aggravating factors and topical treatment: a report from the BAMSE birth cohort Get access N. Ballardini, N. Ballardini Institute of Environmental Medicine, Karolinska Institutet, Stockholm SE‐171 77, SwedenSachs’ Children’s Hospital, Södersjukhuset, Stockholm, Sweden Natalia Ballardini. E‐mail: natalia.ballardini@ki.se Search for other works by this author on: Oxford Academic Google Scholar I. Kull, I. Kull Sachs’ Children’s Hospital, Södersjukhuset, Stockholm, SwedenDepartment of Clinical Science and Education, Södersjukhuset, Karolinska Institutet, Stockholm, Sweden Search for other works by this author on: Oxford Academic Google Scholar C. Söderhäll, C. Söderhäll Department of Biosciences and Nutrition, Karolinska Institutet, Stockholm, Sweden Search for other works by this author on: Oxford Academic Google Scholar G. Lilja, G. Lilja Sachs’ Children’s Hospital, Södersjukhuset, Stockholm, SwedenDepartment of Clinical Science and Education, Södersjukhuset, Karolinska Institutet, Stockholm, Sweden Search for other works by this author on: Oxford Academic Google Scholar M. Wickman, M. Wickman Institute of Environmental Medicine, Karolinska Institutet, Stockholm SE‐171 77, SwedenSachs’ Children’s Hospital, Södersjukhuset, Stockholm, Sweden Search for other works by this author on: Oxford Academic Google Scholar C.F. Wahlgren C.F. Wahlgren Dermatology and Venereology Unit, Department of Medicine Solna, Karolinska University Hospital Solna, Karolinska Institutet, Stockholm, Sweden Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 168, Issue 3, 1 March 2013, Pages 588–594, https://doi.org/10.1111/bjd.12196 Published: 01 March 2013 Article history Accepted: 15 November 2012 Published: 01 March 2013
Abstract P241: The Impact of Dietary and Metabolic Risk Factors on Cardiovascular Diseases and Type 2 Diabetes in Brazil
Authors: Marcia C de Oliveira Otto, Renata Micha, Shahab Khatibzadeh, Gitanjali Singh, Ashkan Afshin, Saman Fahimi, Goodarz Danaei, Dariush Mozaffarian
Journal: Circulation (2014)

Background: Brazil, the 5th largest country in the world, is undergoing a nutrition transition toward unhealthy diets and greater incidence of cardiometabolic diseases (CM). However, little is known about the quantitative impact of major dietary and metabolic risk factors on current burdens of CVD and diabetes in Brazil. Aims: To quantify using consistent and comparable methods the CVD and diabetes mortality attributable to suboptimal diet and metabolic factors in Brazil. Methods: Based on data from 2010 Global Burden of Disease Study, we used a comparative risk assessment framework to develop consistent and comparable methods to identify dietary and metabolic risk factors with evidence for etiologic effects on CVD and diabetes; estimate current national intake levels and their uncertainty, by age and sex; quantify etiologic effects of each diet-disease relationship, by age; and characterize optimal consumption levels. We combined these inputs with national data on disease-specific deaths to estimate overall burdens attributable to each dietary factor, and by age, sex, and disease. We quantified uncertainty using probabilistic simulation analyses, incorporating uncertainty in dietary exposure data and etiologic effects by age, and sex. Missing exposure data was imputed using a multi-level hierarchical Bayesian model based on non-missing exposure data from other regions. Robustness of findings was evaluated by sensitivity to varying inputs including effect sizes and feasible optimal levels. Results: Among dietary factors, low intake of fruits and whole grains had highest impacts on CM mortality, each responsible for ~12% of total CM deaths (62,800 and 61,400 deaths, respectively) (Figure). Hypertension and high fasting plasma glucose were responsible for 32% (163,000) and 28% (141,700) of CM deaths respectively. Other dietary and metabolic risk factors also caused substantial numbers of deaths among Brazilians. Conclusion: Our findings inform priorities for policy measures to reduce CVD and diabetes in Brazil.
Recurrent Coronary Vasoconstriction Caused by Intranasal Cocaine: Possible Role for Metabolites
Authors: Walter C. Brogan, Richard A. Lange, D. Brent Glamann, L. David Hillis
Journal: Annals of Internal Medicine (1992)

Objective: To define the temporal characteristics of cocaine-induced coronary vasoconstriction in humans and to assess the relation between cocaine-induced coronary vasoconstriction and the blood concentration of cocaine and its main metabolites. Design: Randomized, double-blind, controlled clinical trial. Setting: Cardiac catheterization laboratory of a large teaching hospital. Patients: Eighteen patients (16 men and 2 women, 37 to 65 years of age) having catheterization for evaluation of chest pain. Measurements: At catheterization, patients received intranasal saline (8 patients) or cocaine, 2 mg/kg body weight (10 patients). Cineangiographic examination of the left coronary artery and quantitation of the blood concentration of cocaine and its metabolites were done before (baseline) and 30, 60, and 90 minutes after administration of intranasal saline or cocaine. Results: In response to cocaine, proximal coronary arterial diameter decreased from 2.4 ± 1.6 mm (mean ± SD) at baseline to 2.0 ± 1.4 mm at 30 minutes (P < 0.05). This change corresponded temporally to the peak blood concentration of cocaine. At 60 minutes, the cocaine concentration decreased and coronary artery diameter returned to baseline (2.3 ± 1.6 mm) (P > 0.05 compared with baseline). At 90 minutes, all patients had recurrent vasoconstriction (1.9 ± 1.4 mm, P < 0.05) despite a further decrease in the blood cocaine concentration. This vasoconstriction corresponded temporally with an increasing blood concentration of cocaine's main metabolites, benzoylecgonine and ethyl methyl ecgonine. No changes were observed in the control group. $ Conclusion: Intranasal cocaine causes recurrent coronary vasoconstriction, which may be due to its metabolites.
Abstract 16875: Mortality Rates Among Patients With Venous Thromboembolism on Anticoagulant Therapy
Authors: Edith Nutescu, Xue Song, Brahim Bookhart, Nianwen Shi, Monika Raut, C V Damaraju, Jeff Schein, Scott Kaatz
Journal: Circulation (2014)

Background:  Venous thromboembolism (VTE), comprising deep vein thrombosis (DVT) and pulmonary embolism (PE), is associated with significant morbidity and mortality. The prognosis for patients who develop DVT or PE is directly related to the risk of recurrent events and other complications, such as bleeding. These complications, along with patient-specific factors, may result in additional mortality risk.   Objectives:  To determine the rate of all-cause mortality during follow-up based on the type (cancer provoked, surgery/pregnancy/oral contraception-provoked, or unprovoked) of DVT and PE.   Methods:  A large US claims database was used to identify patients who had DVT or PE, ≥1 anticoagulant prescription, and were linked to the Social Security Administration file from 7/1/2006 to 7/31/2013. All patients were ≥18 years old, had continuous database enrollment and no VTE or anticoagulant use in the 6 months preceding the index diagnosis of VTE. All patients were followed until death or end of study. Bleeding and recurrent VTE were assessed separately for DVT and PE; all-cause mortality was further assessed according to type of VTE. Bleeding was defined as occurring in a critical site. Recurrent VTE was defined as hospitalization with VTE as the primary discharge diagnosis or re-initiation of anticoagulation treatment after a 60-day gap.   Results:  Of 108,184 patients, 62% had DVT and 38% PE (Table). Of all VTE, 20% were classified as cancer-provoked, 20% as surgery/pregnancy/contraception-provoked, and 60% as unprovoked. Recurrent VTE and bleeding event rates were similar between patients with DVT and PE. Patients with VTE provoked by cancer had the highest mortality rates.   Conclusions:  Recurrent VTE and bleeding was common after an index event in this large patient database, and all-cause mortality was considerable, particularly in cancer patients. Our work underscores the importance of physician awareness of risk factors that influence a patient’s outcome after VTE.
Intravitreal triamcinolone acetonide for diabetic diffuse macular edema11The authors have no proprietary interest in this study. 22Dr Audren, co–first author, contributed equally to the work.
Authors: Pascale Massin, François Audren, Belkacem Haouchine, Ali Erginay, Jean-François Bergmann, Rym Benosman, Charles Caulin, Alain Gaudric
Journal: Ophthalmology (2004)
Modulation of arachidonic acid metabolism by curcumin and its β-diketone derivatives in RAW 264.7 murine macrophages
Authors: Jungil Hong, Mousumi Bose, Jihyeung Ju, Xiaoxin Chen, Chung S. Yang
Journal: Cancer Research (2004)

1395  Aberrant arachidonic acid metabolism is involved in inflammatory and carcinogenic processes. In the present study, we investigated the effects of curcumin, and its β-diketone derivatives on the molecular regulation of the enzymes related to arachidonic acid metabolism in the lipopolysaccharide (LPS)-stimulated murine macrophage RAW 264.7 cells. Curcumin and its β-diketone derivatives, tetrahydrocurcumin (THC) and dibenzoylmethane (DBM) significantly inhibited LPS-stimulated release of arachidonic acid and its metabolites. Stimulation of the macrophages with LPS induced the phosphorylation of cytosolic phospholipase A2 (cPLA2) without changing the protein level. Curcumin inhibited cPLA2 phosphorylation in a concentration-dependent manner. Curcumin (20 μM) increased nuclear translocation of cPLA2 after 16 h of treatment, but subsequent release of arachidonic acid and its metabolites after the time point was still slightly decreased, compared to control without curcumin. Curcumin strongly inhibited LPS-induced cyclooxygenases-2 (COX-2) expression. The levels of 5-lipoxygenase (5-LOX), microsomal prostaglandin E synthase (mPGES) and leukotriene A4 hydrolase (LTA4H) were not significantly changed after stimulation with LPS. Curcumin slightly decreased 5-LOX; the protein levels of LTA4H and mPGES, however, were not affected by curcumin up to 20 μM. The level of prostaglandin E2 (PGE2) was markedly increased after stimulation with LPS, whereas there was no significant change in the level of leukotriene B4 (LTB4). Curcumin and THC (10 μM) potently inhibited the formation of PGE2 and LTB4; DBM, however, increased the LTB4 level. The results suggest that curcumin affects multiple stages of arachidonic acid metabolizing enzymes by modulating their catalytic activities as well as molecular regulation. This activity may contribute to their anti-carcinogenic and anti-inflammatory actions (supported by NIH grant CA88961).
Transplantation of unrelated donor umbilical cord blood in 102 patients with malignant and nonmalignant diseases: influence of CD34 cell dose and HLA disparity on treatment-related mortality and survival
Authors: John E. Wagner, Juliet N. Barker, Todd E. DeFor, K. Scott Baker, Bruce R. Blazar, Cindy Eide, Anne Goldman, John Kersey, William Krivit, Margaret L. MacMillan, Paul J. Orchard, Charles Peters, Daniel J. Weisdorf, Norma K. C. Ramsay, Stella M. Davies
Journal: Blood (2002)
Abstract 15468: Age- and Gender-specific 99th Percentile Cut-offs for Diagnosis of Myocardial Infarction and Prognostic Implications - Results From the High Sensitivity Cardiac Troponin T Assay for Rapid Rule-out of Acute Myocardial Infarction Substudy
Authors: Matthias Mueller, Bertil Lindahl, Evangelos Giannitsis, Hugo A Katus, Silvia Weiser, Garnet Bendig, Peter Dilba, Christian Mueller
Journal: Circulation (2014)

Objective: We aimed to evaluate the impact of age- and gender-specific cut-offs in comparison to the general 99th percentile cut-off for diagnosis and prognosis of acute myocardial infarction (AMI). Methods: 1282 unselected patients presenting with suspected AMI and recent (<6h) onset of chest pain to the emergency department were enrolled as part of the TRAPID-AMI study and 359 patients with non-ST-elevation acute coronary syndrome (NSTE-ACS) qualified for further subanalysis. Patients were classified using age- and gender-dependent hs-TnT 99th percentile cut-off values previously described in literature (28 ng/L for ≥65y, 9 ng/L for female and 15.5 ng/L for male patients) in comparison to the general cut-off of 14 ng/L. Results: Table 1 displays changes regarding diagnostic reclassification and outcomes when comparing age-specific and general 99th percentile cut-off values in NSTE-ACS patients with age ≥65y (n=216). Significant reclassification concerning 1-month and 3-month mortality could be observed ...
Reduction in rotavirus after vaccine introduction - United States, 2000-2009.
Authors: C. A. Panozzo, J. E. Tate, D. C. Payne, M. M. Cortese, M. Patel, J. Gentsch, U. Parashar, J. E. Cortes, D. H. Esposito
Journal: MMWR Morbidity and Mortality Weekly Report (2009)
Medicare Cancer Coverage
Authors: Tracy Hampton
Journal: JAMA (2004)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Abstract 3846: Hierarchical and Critical Functions of Ser282 Phosphorylation in Cardiac Myosin Binding Protein-C Phosphorylation and Cardiac Function
Authors: Sakthivel Sadayappan, James Gulick, Lisa A Martin, Friederike Cuello, Metin Avkiran, John N Lorenz, Jeffrey Robbins
Journal: Circulation (2009)

Background: Cardiac myosin binding protein-C (cMyBP-C) phosphorylation at Ser273, Ser282 and Ser302 regulates myocardial function and can be cardioprotective during heart failure. PKA, PKC and CaMK...
Community-Acquired Pneumonia and Use of Gastric Acid–Suppressive Drugs
Authors: Robert T Sataloff
Journal: JAMA (2005)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Radiation Therapy Significantly Improves Survival Of Patients With Diffuse Large B-Cell Lymphoma Associated With MYC Translocation: A Report From The International DLBCL Rituximab-CHOP Consortium Program
Authors: Zijun Y. Xu-Monette, Bouthaina S. Dabaja, Alexander Tzankov, Carlo Visco, Roberto N. Miranda, Karen Dybkaer, April Chiu, Attilio Orazi, Youli Zu, Govind Bhagat, Kristy L. Richards, Eric D. Hsi, Wai Lap Choi, Joannes H.J.M. Van Krieken, Jooryung Huh, Weiyun Z. Ai, Maurilio Ponzoni, Andres Ferreri, Michael B. Moller, Xiaoying Zhao, Ronald S. Go, Jane N. Winter, Miguel Angel A. Piris, Timothy J. McDonnell, Yong Li, L. Jeffrey Medeiros, Ken H. Young
Journal: Blood (2013)
Gastro-oesophageal and obesity are both independently related to newly developed asthma in adults
Authors: M I Gunnbjörnsdottir, T Gislason, R Jogi, E Jensen, E Norrman, E Omenaas, K Thoren, C Janson
Journal: European Respiratory Journal (2002)

Gastro-oesophageal and obesity are both independently related to newly developed asthma in adults
Abstract 11398: Difference of Tissue Characteristics of Restenosis Lesion Between Drug-Eluting Stent and Bare-Metal Stent : Optical Coherence Tomography Analysis
Authors: Maoto Habara, Mitsuyasu Terashima, Kenay Nasu, Yoshihiro Ko, Tsuyoshi Ito, Soichiro Ebisawa, Tairo Kurita, Nobuyoshi Tanaka, Masashi Kimura, Tatsuya Ito, Mariko Ehara, Yoshihisa Kinoshita, Etsuo Tsuchikane, Yasushi Asakura, Osamu Kato, Takahiko Suzuki
Journal: Circulation (2010)
The common PPARγ Pro12Ala polymorphism is associated with decreased risk of type 2 diabetes
Authors: David Altshuler, Joel N. Hirschhorn, Mia Klannemark, Cecilia M. Lindgren, Marie-Claude Vohl, James Nemesh, Charles R. Lane, Stephen F. Schaffner, Stacey Bolk, Carl G. Brewer, Tiinamaija Tuomi, Daniel Gaudet, Thomas J. Hudson, Mark J. Daly, Leif Groop, Eric S. Lander
Journal: Nature Genetics (2000)