THE OXYHEMOGLOBIN DISSOCIATION CURVE IN ANEMIA
Authors: T RODMAN, H P CLOSE, M K PURCELL
Journal: Annals of Internal Medicine (1960)

Article1 February 1960THE OXYHEMOGLOBIN DISSOCIATION CURVE IN ANEMIATHEODORE RODMAN, M.D., HENRY P. CLOSE, M.D., F.A.C.P., MAY K. PURCELLTHEODORE RODMAN, M.D., HENRY P. CLOSE, M.D., F.A.C.P., MAY K. PURCELLAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-52-2-295 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe primary function of hemoglobin is the transport of oxygen from the lungs to the tissues. Anemia compromises this transport mechanism and exposes the tissues to the dangers of hypoxia. The fact that patients with slowly developing anemia are frequently symptom-free with low levels of circulating hemoglobin strongly suggests that efficient compensatory mechanisms are available to provide an adequate supply of oxygen to the tissues. There are two generally recognized compensatory mechanisms: a reduced tissue oxygen tension, which results in more nearly complete extraction of oxygen from the blood, and an increased cardiac output. Both of these mechanisms entail disadvantages—a...Bibliography1. FraimowRodmanCloseCathcartPurcell WTHPRMK: The oxyhemoglobin dissociation curve in sickle cell anemia, Am. J. M. Sc. 236: 225-232, 1958. CrossrefMedlineGoogle Scholar2. RodmanCloseCathcartPurcell THPRMK: The oxyhemoglobin dissociation curve in the common hemoglobinopathies, Am. J. Med. 27: 558-566, 1959. CrossrefMedlineGoogle Scholar3. RichardsStrauss DWML: The oxyhemoglobin dissociation curves of whole blood in anemia, J. Clin. Investigation 4: 105-126, 1927. CrossrefMedlineGoogle Scholar4. KennedyValtis ACDJ: The oxygen dissociation curve in anemia of various types, J. Clin. Investigation 33: 1372-1381, 1954. CrossrefMedlineGoogle Scholar5. 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Author, Article, and Disclosure InformationAuthors: THEODORE RODMAN, M.D.; HENRY P. CLOSE, M.D., F.A.C.P.; MAY K. PURCELLAffiliations: Philadelphia, Pennsylvania*Received for publication May 16, 1959.Presented at the Fortieth Annual Session of The American College of Physicians, Chicago, Illinois, April 22, 1959.From the Medical Service and Cardio-pulmonary Division of the Medical Research Laboratory, Philadelphia Veterans Administration Hospital.With the technical assistance of GERTRUDE STILL, A.B., Philadelphia, Pennsylvania.Requests for reprints should be addressed to Theodore Rodman, M.D., Medical Service, Philadelphia Veterans Administration Hospital, Philadelphia 4, Pennsylvania. 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GRANT, M.D., F.A.C.P., BARRY SMITH, M.D. 1 February 1960Volume 52, Issue 2Page: 295-309KeywordsAnemiaBloodCardiac outputHemoglobinHypoxiaLungsMedical servicesOxygenOxyhemoglobinResearch laboratories ePublished: 1 December 2008 Issue Published: 1 February 1960 PDF downloadLoading ...