tbuckley/cabot-search huggingface dataset:
Sequential Bacteremia and Fungemia Associated With Carcinoma of the Colon
Authors: Anand P. Panwalker
Journal: JAMA (1982)

<h3>To the Editor.—</h3> The association of<i>Streptococcus bovis</i>bacteremia and endocarditis with lesions of the gastrointestinal (GI) tract is well recognized.<sup>1</sup>The report of multiorganism septicemia and carcinoma of the colon (1982;247:1812) was of interest because we have recently seen a patient with sequential bacteremia and fungemia who also had colonic carcinoma. <h3>Report of a Case.—</h3> An 84-year-old man was admitted to the Wilmington Veterans Administration Medical Center, Wilmington, Del, with a history of anorexia and weight loss for two months. Physical examination disclosed an emaciated, confused, and combative patient with evidence of severe dehydration. He was afebrile with a BP of 90/60 mm Hg and tachycardia. There was a painful swelling of the right lower leg. Results of the physical examination were otherwise normal. Laboratory studies disclosed the following results: WBC count, 21,300/cu mm, with 90% polymorphonuclear cells; hemoglobin, 9.7 mg/dL; creatinine, 2.2 mg/dL; serum urea nitrogen, 89
Carotid Intima-Media Thickness in Hyperlipidemic Type I and Type II Diabetic Patients
Authors: Suzan D J M Kanters, Ale Algra, Jan-Dirk Banga
Journal: Diabetes Care (1997)

OBJECTIVE Ultrasonographic measurements of the combined thickness of the carotid intima and media can be used to examine early vessel wall changes in atherosclerosis. Premature atherosclerosis is common in diabetes, especially when other risk factors are present. Intima-media thickness was quantified in hyperlipidemic type I and type II diabetic patients, and relationships between various risk factors and intima-media thickness were investigated. RESEARCH DESIGN AND METHODS Thirty-one patients with type I diabetes and 56 with type II diabetes were examined, with an LDL cholesterol of &amp;gt; 2.6 mmol/l and/or triglycerides of &amp;gt; 1.7 mmol/l and/or HDL cholesterol of &amp;lt; 0.9 mmol/l for men or &amp;lt; 1.1 mmol/l for women. Intima-media thickness was measured on-line, over a length of 1 cm in the common carotid artery. Later, the mean and the maximum of six measurements was calculated (left and right side, both in three directions). RESULTS Mean intima-media thickness was 0.63 ± 0.18 (±SD) mm for type I diabetes and 0.80 ± 0.31 mm for type II diabetes. Adjusted for age, the difference was 0.06 mm, with a 95% CI of −0.08 to 0.20 mm. In multivariate regression analysis, age over 50 years and higher HbA1c were independently associated with an increase in mean intima-media thickness in type I diabetes. In type II diabetes, none of the variables reached a significance level of ≤ 0.10. Results for maximum intima-media thickness were essentially the same. CONCLUSIONS In general, intima-media thickness is larger in type II diabetes than in type I diabetes. The effect of age is absent in type II diabetes, whereas in type I diabetes, age and blood glucose control have an important effect on intima-media thickness.
Lactobacillus acidophilus modulates intestinal pain and induces opioid and cannabinoid receptors
Authors: Christel Rousseaux, Xavier Thuru, Agathe Gelot, Nicolas Barnich, Christel Neut, Laurent Dubuquoy, Caroline Dubuquoy, Emilie Merour, Karen Geboes, Mathias Chamaillard, Arthur Ouwehand, Greg Leyer, Didier Carcano, Jean-Frédéric Colombel, Denis Ardid, Pierre Desreumaux
Journal: Nature Medicine (2006)
Pancreaticobiliary Cancers With Deficient Methylenetetrahydrofolate Reductase Genotypes
Authors: Hiroyuki Matsubayashi, Halcyon G. Skinner, Christine Iacobuzio-donahue, Tadayoshi Abe, Norihiro Sato, Taylor Sohn Riall, Charles J. Yeo, Scott E. Kern, Michael Goggins
Journal: Clinical Gastroenterology and Hepatology (2005)
Étude de l'oesophage de Barrett en endomicroscopie confocale par minisonde Cellvizio-GI; résultats préliminaires
Authors: J Boyer, S Michalak, D O'Toole, P Burtin, D Luet, B Person
Journal: Endoscopy (2008)

Introduction: L'endomicroscopie confocale utilise une excitation en lumière bleue et collecte une lumière en fluorescence produite par des fluophores captés par un détecteur à balayage permettant de générer des images microscopiques de muqueuse digestive. But: tester une nouvelle technique d'endomicroscopie confocale par minisonde (Cellvizio®-GI) chez des patients sélectionnés présentant un EBO.
Association of haptoglobin genetic polymorphism with overall survival in advanced castration-resistant prostate cancer patients with personalized peptide vaccination
Authors: Nobukazu Komatsu, Xiaoliang Pang, Hiromitsu Araki, Yoshiro Koda, Kimiko Soejima, Tetsuro Sasada, Kosuke Tashiro, Satoru Kuhara, Kyogo Itoh
Journal: Journal for ImmunoTherapy of Cancer (2013)

Meeting abstracts Although a peptide vaccination is potentially useful for cancers, there are some patients who do not show clinically beneficial response to this treatment. Previously, we have demonstrated gene expression profiling of pre-vaccination peripheral blood mononuclear cells in advanced
Digital angiographic impulse response analysis of regional myocardial perfusion. Estimation of coronary flow, flow reserve, and distribution volume by compartmental transit time measurement in a canine model.
Authors: N L Eigler, H Schühlen, J S Whiting, J M Pfaff, A Zeiher, S Gu
Journal: Circulation Research (1991)

A system impulse response function that describes the kinetics of radiographic contrast material transit through the coronary circulation was calculated from 175 selective digital angiograms of normal and stenotic arteries in 10 dogs during rest and hyperemia. The goal of the study was to determine if the flow and distribution volume characteristics of the epicardial coronary arteries and the myocardial microcirculation could be stimulated by specific mathematical compartments of a lagged normal density model impulse response function in which the flow/distribution volume ratio is the inverse of the mean transit time. The arterial compartment mean transit time correlated with flow (r = 0.75); however, the correlation was significantly improved in individual dogs (r = 0.83 +/- 0.13; p less than 0.005) and was highly dependent on the length of the conduit vessel. The microcirculation compartment mean transit time was distributed as two populations with respect to flow. There was a linear correlation during hyperemia (r = 0.87) and a nonlinear relation during rest, which was characteristic of an autoregulating system. Resting values of microcirculation compartment mean transit time correlated with coronary flow reserve (r = 0.84) and differed significantly between vessels that were normal and those with subcritical stenosis, critical stenosis, or total occlusion (p less than 0.01 for all comparisons). The estimated microcirculation compartment distribution volume increased from a minimum of 4.0 +/- 1.5 ml/100 g myocardium in normal vessels with resting flow to 11.2 +/- 3.5 ml/100 g during hyperemia. These data suggest that the model compartments functionally describe the physiological behavior of their anatomic analogues and permit the quantification of microcirculatory autoregulation from a single measurement at rest without provoking hyperemia.
Common waiting lists
Authors: J J Shipman, K W Giles, E C S Talbot, R H Armour, W F Millner, J M Lancaster, W K Essigman, B H Jackson
Journal: BMJ (1977)

<h3>Background</h3> This is a retrospective review of 25 patients with severe lumbar nerve root compression undergoing multilevel anterior retroperitoneal lumbar interbody fusion and posterior instrumentation for deformity. The objective is to analyze the outcomes and clinical results from anterior interbody fusions performed through a lateral approach and compare these with traditional surgical procedures. <h3>Methods</h3> A consecutive series of 25 patients (78 extreme lateral interbody fusion [XLIF] levels) was identified to illustrate the primary advantages of XLIF in correcting the most extreme of the 3-dimensional deformities that fulfilled the following criteria: (1) a minimum of 40° of scoliosis; (2) 2 or more levels of translation, anterior spondylolisthesis, and lateral subluxation (subluxation in 2 planes), causing symptomatic neurogenic claudication and severe spinal stenosis; and (3) lumbar hypokyphosis or flat-back syndrome. In addition, the majority had trunks that were out of balance (central sacral vertical line ≥2 cm from vertical plumb line) or had sagittal imbalance, defined by a distance between the sagittal vertical line and S1 of greater than 3 cm. There were 25 patients who had severe enough deformities fulfilling these criteria that required supplementation of the lateral XLIF with posterior osteotomies and pedicle screw instrumentation. <h3>Results</h3> In our database, with a mean follow-up of 24 months, 85% of patients showed evidence of solid arthrodesis and no subsidence on computed tomography and flexion/extension radiographs. The complication rate remained low, with a perioperative rate of 2.4% and postoperative rate of 12.2%. The lateral listhesis and anterior spondylolisthetic subluxation were anatomically reduced with minimally invasive XLIF. The main finding in these 25 cases was our isolation of the major indication for supplemental posterior surgery: truncal decompensation in patients who are out of balance by 2 cm or more, in whom posterior spinal osteotomies and segmental pedicle screw instrumentation were required at follow up. No patients were out of sagittal balance (sagittal vertical line &lt;3 cm from S1) postoperatively. Segmental instrumentation with osteotomies was also more effective for restoration of physiologic lumbar lordosis compared with anterior stand-alone procedures. <h3>Conclusions</h3> This retrospective study supports the finding that clinical outcomes (coronal/sagittal alignment) improve postoperatively after minimally invasive surgery with multilevel XLIF procedures and are improved compared with larger extensile thoracoabdominal anterior scoliosis procedures.
Nosocomial Transmission of Vancomycin-Resistant Enterococci From Surfaces
Authors: A. J. Ray
Journal: JAMA (2002)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
SIECUS and Sex Education
Authors: Ruth A. Frary
Journal: JAMA (1969)

<h3>To the Editor:—</h3> As a physician of 30 years, a wife, a mother, a teacher of sex education at various times during my career, from the fourth grade up through college level, and a lecturer to teachers and physicians in sex education, it is difficult for me to understand the emotional and irrational arguments put forth by many of the writers to your publication. If the mere giving of information about the various aspects of health and human behavior problems were as effective as the opponents of sex education think it is going to be, no one would have dental problems, there would be no alcoholism, and we would long since have eliminated tobacco as a hazardous substance. For the evils of tobacco and alcohol and the benefits of tooth brushing and personal cleanliness have been standard teaching in health courses, starting in kindergarten, for many years. What health and
Hemolytic Anemia after Tetracycline Therapy
Authors: Marcus B. Simpson, Joanne Pryzbylik, Bruce Innis, Mary Ann Denham
Journal: New England Journal of Medicine (1985)

ACQUIRED immune hemolytic anemia can occur after exposure to a number of commonly used drugs. Among the best-documented offenders are penicillin, methyldopa, and quinidine, each of which is believed to act through a different mechanism.1 Although tetracyclines have been implicated in a variety of adverse reactions, hemolytic anemia has only rarely been described.2 3 4 We report on a patient who had acute intravascular hemolysis with hemoglobinemia, hemoglobinuria, thrombocytopenia, hypofibrinogenemia, and transient renal impairment on at least two occasions after oral use of tetracycline. The patient's serum contained an IgG antibody that reacted only with red cells exposed either in vivo or . . .
Fundholding and prescribing
Authors: A D Shaw
Journal: BMJ (1995)

Fundholders with more modest prescribing history receive less recognition

EDITOR,--Jon S Dowell and colleagues report having achieved a saving in their drug budget of £137712, much of which has been used to benefit their patients and their premises.1 Their experience contrasts sharply with our experience of fundholding in the same health board area.

I work in a semirural practice that has five principals and 7800 patients. We embarked on fundholding in December 1991 as part of a pilot project among small practices. As the rules on list size for …
Decision to dismiss head of German NICE is "shabby," says MP
Authors: A. Tuffs
Journal: BMJ (2010)

Opposition parties have accused the German government of bowing to pressure from the drug industry over its decision to dismiss the head of the country’s healthcare quality and efficiency body. One MP called the decision “shabby.”

Peter Sawicki’s tenure as director of the Institute for Quality and Efficiency in Health Care will not be prolonged beyond 31 August 2010, and a new director will be installed on 1 September. Earlier this month more than 600 doctors signed a petition in support of Dr Sawicki remaining in post ( BMJ 2010;340:c318, 18 Jan, doi:10.1136/bmj.c318). …
Multifaceted roles of cyclooxygenase-2 in lung cancer
Authors: Karen Riedl, Kostyantyn Krysan, Mehis Põld, Harnisha Dalwadi, Nathalie Heuze-Vourc’h, Mariam Dohadwala, Ming Liu, Xiaoyan Cui, Robert Figlin, Jenny T Mao, Robert Strieter, Sherven Sharma, Steven M Dubinett
Journal: Drug Resistance Updates (2004)
Biological Agents for Moderately to Severely Active Ulcerative Colitis
Authors: Silvio Danese, Gionata Fiorino, Laurent Peyrin-Biroulet, Ersilia Lucenteforte, Gianni Virgili, Lorenzo Moja, Stefanos Bonovas
Journal: Annals of Internal Medicine (2014)

Biological agents are emerging treatment options for the management of ulcerative colitis (UC).To assess the comparative efficacy and harm of biological agents in adult patients with moderately to severely active UC who are naive to biological agents.MEDLINE, EMBASE, and Cochrane Library from inception through December 2013, without language restrictions, and ClinicalTrials.gov, European Medicines Agency, and U.S. Food and Drug Administration Web sites.Randomized, placebo-controlled or head-to-head trials assessing biological agents as induction or maintenance therapy for moderately to severely active UC.Two reviewers independently abstracted study data and outcomes and rated each trial's risk of bias.There were no head-to-head trials. There were 7 double-blind, placebo-controlled trials that were rated as low risk of bias and showed that all biological agents (adalimumab, golimumab, infliximab, and vedolizumab) resulted in more clinical responses, clinical remissions, and mucosal healings than placebo for induction therapy. The results of network meta-analysis suggested that infliximab is more effective to induce clinical response (odds ratio, 2.36 [95% credible interval, 1.22 to 4.63]) and mucosal healing (odds ratio, 2.02 [95% credible interval, 1.13 to 3.59]) than adalimumab. No other indirect comparison reached statistical significance. For maintenance, 6 double-blind, placebo-controlled trials that were rated high risk of bias showed that all biological agents have greater clinical efficacy than placebo. The occurrence of adverse events was not different between biological agents and placebo.Few trials, no head-to-head comparisons, and inadequate follow-up in maintenance trials.Biological agents are effective treatments for UC, but head-to-head trials are warranted to establish the best therapeutic option.
Babinski and the Plantar Reflex
Authors: Monroe Cole
Journal: JAMA (1963)

<h3>To the Editor:</h3> —I wish to call your attention to an error in the editorial, "Babinski and the Plantar Reflex" (<i>JAMA</i><b>183:</b>281 [Jan 26] 1963). As written, one is led to believe that the so-called Babinski-Nageotte syndrome has to do with locomotor ataxia. The latter term refers to ataxia dependent upon loss of sense of position and has historically been linked to tabes dorsalis. The so-called Babinski-Nageotte syndrome is based on a paper read at the Société de Neurologie de Paris, April 17, 1902, and published under the title "Hémiasynergie, latéropulsion et myosis bulbaires avec hémianesthésie et hémiplégie croisées" (<i>Rev Neurol</i>[Paris]<b>10:</b>358, 1902). Three patients had been seen but only one case was presented in detail. The patient, a 50-yr-old luetic, had headache, vertigo, dysphagia, nasal regurgitation, and a nasal voice. The palatal reflex was abolished. Sensations of touch and temperature were deficient on the right side
A Familial Syndrome of Pericarditis, Arthritis, and Camptodactyly
Authors: Manuel Martínez-Lavín, Alfonso Buendía, Egle Delgado, Pedro Reyes, Mary-Carmen Amigo, Jaime Sabanés, Antonio Zghaib, Fause Attié, Luis Salinas
Journal: New England Journal of Medicine (1983)

FIVE siblings in a family with seven children had a combination of abnormal findings, including constrictive pericarditis, arthritis of large joints, and flexion contracture of the fingers. This familial cluster of pathologic features appears to be a distinct syndrome; we have been unable to find similar cases described in the literature.Case ReportsThe family came from a small village in southern Mexico. The parents denied consanguinity. Similar cases were not known to be present in their community. The pedigree and the determination of HLA antigens for the A and B loci are shown in Figure 1.Case 1 (Propositas)A . . .
Abstract 3509: Intracranial administration of activated NK-cells and mAb9.2.27 against NG2/CSPG4 activates microglial cytotoxicity and prolongs survival in glioblastoma xenograft model
Authors: Aurelie Poli, Jian Wang, Olivia Domingues, Tao Yan, Frits Thorsen, Cecilie Brekke-Rygg, Francois Hentges, Paal Henning Pedersen, Jacques Zimmer, Per Øyvind Enger, Martha Chekenya
Journal: Cancer Research (2012)

Abstract Glioblastoma multiforme (GBM) is the most malignant brain tumour in adults with dismal prognosis despite multimodal treatment. We have previously shown that the NG2 proteoglycan mediates an aggressive disease course in GBMs and therefore aimed to target it using the monoclonal antibody 9.2.27 and adoptively transferred natural killer (NK) cells in athymic rats. We demonstrated that intracranial administration of activated NK cells and mAb9.2.27 eradicated established GBM and led to significantly increased survival, mediated by diminished tumour proliferation and increased cell death. The mechanisms involved sustained activation of pro-inflammatory ED1+CD8+ microglia and subsequent development of a Th1 immune response in the combination therapy compared to monotherapy controls. The Th1 response was characterized by increased tumour infiltration by CD4+ and CD8+ T cells, as well as augmented IFN-γ and TNF-α release into the cerebrospinal fluid. Furthermore, we showed that activated NK cells released IFN-γ and TNF-α, they shifted activated microglia from M2- to highly cytotoxic M1-like phenotype and preferentially killed M2-microglia compared to M1-microglia in vitro. These findings implicate NK cells in the pro-inflammatory environment that facilitated the tumour cytotoxicity by microglia in vivo. Our results suggest that the administration of activated NK cells and mAb9.2.27 is a promising approach to treat GBM. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 103rd Annual Meeting of the American Association for Cancer Research; 2012 Mar 31-Apr 4; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2012;72(8 Suppl):Abstract nr 3509. doi:1538-7445.AM2012-3509
Abstract 370: Characterization of human umbilical vein endothelial cell clones resistant to VEGFR2 tyrosine kinase inhibitor
Authors: Kazuko Matsumoto, Tokuzo Arao, Kazuyuki Furuta, Kazuko Sakai, Tomoyuki Nagai, Kanae Kudo, Hiroyasu Kaneda, Daisuke Tamura, Keiichi Aomatsu, Yoshihiko Fujita, Kazuto Nishio
Journal: Cancer Research (2010)

Abstract Acquired resistance to anti-angiogenetic drugs have emerged as a potentially important problem in clinical settings, however, the underlying mechanism remains largely unclear. In this study, we established human umbilical vein endothelial cell (HUVEC) clones that are resistant to VEGFR tyrosine kinase inhibitor (VEGFR-TKI, Ki8751) using MNNG and VEGFR-TKI. In growth inhibition assay, VEGFR-TKI resistant HUVEC clones were significantly decreased cellular sensitivity to Ki8751 about 4-10 fold compared with that in the parental cells. VEGF-mediated cellular proliferations of resistant clones were also decreased. Interestingly, VEGFR2 expression was down-regulated and the phosphorylation levels of Akt were up-regulated in resistant clones. Finally, microarray analysis revealed that several angiogenesis-related or -specific genes including CD31 were remarkably down-regulated in resistant clones compared with the parental cells. In conclusion, these results suggest that the mechanism of VEGFR-TKI resistant is closely involved in “escape phenomenon” from VEGF-VEGFR system and our findings provide a novel insight into the drug resistant to VEGFR-TKI in vascular endothelial cells. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 101st Annual Meeting of the American Association for Cancer Research; 2010 Apr 17-21; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2010;70(8 Suppl):Abstract nr 370.