tbuckley/cabot-search huggingface dataset:
Spectrum of efficacy of valproate in 55 patients with rapid-cycling bipolar disorder
Authors: Joseph R. Calabrese, Gustave A. Delucchi
Journal: American Journal of Psychiatry (1990)

In order to explore valproate's spectrum of efficacy in rapid-cycling bipolar disorder, 55 patients underwent a prospective, open, 7.8-month trial designed to assess the drug's acute and prophylactic properties. Twenty patients received monotherapy, and 35 received combination therapy. Moderate to marked acute antidepressant responses were seen in 47% of the patients, prophylactic antidepressant responses in 76%, acute antimanic responses in 91%, prophylactic antimanic responses in 94%, acute responses in mixed states in 85%, and prophylactic responses in mixed states in 93%. Consistent with other anticonvulsant literature, these data suggest that valproate has marked antimanic and mixed state efficacy, but minimal to moderate antidepressant properties.
B-cell non-Hodgkin's lymphoma cell line (Karpas 1106) with complex translocation involving 18q21.3 but lacking BCL2 rearrangement and expression
Authors: E Nacheva, MJ Dyer, C Metivier, D Jadayel, G Stranks, R Morilla, JM Heward, T Holloway, S O'Connor, PC Bevan
Journal: Blood (1994)
Effectiveness of “Korargin” in the therapy of pulmonary arterial hypertension in patients with systemic lupus erythematosus
Authors: Olga Yakovleva, Aleksandra Klekot
Journal: European Respiratory Journal (2011)

Introduction:  Pulmonary arterial hypertension (PAH) in systemic lupus erythematosus (SLE) is a complex therapeutic problem and occurs from 5 to 14%. The main pathophisiological mechanism of PAH is an endothelium dysfunction with abnormality of nitric oxide synthesis (Ghofrani H.A. et al. J. Am. Coll. Cardiol. 2004; 43; 68S-72S).  Objective was to examine the efficacy of the “Korargin” (1 tabl. contains 0.1g L-arginine and 0.1g inosine), production of “Korargin”, Uman, Ukraine in SLE patients with PAH.   Methods:  30 SLE patients with PAH (mean age is 48.3±1.7 y.)were studied, whom to conventional therapy was added “Korargin” 2 tablets 3 times a day for 8 weeks. The object of the effectiveness were increased distance of 6-minute walk (6MW), changes in pulmonary artery pressure and improvement of functional class (FC) PAH on WHO.   Results:  II FC PAH was diagnosed in 80% patients. Patients with III FC was 20%. From the 4th week and untill the end of the initial study, the patients demonstrated a significant increase in the distance test of 6MW an average of 61.2±3.2 m compared with the baseline data. In addition, it was observed decrease in pulmonary arterial pressure on 11% in 37% of patients. 64% patients improved their FC.   Conclusion:  Despite of the fact, that insufficient long-term follow-up period and relatively non-severe population of SLE patients with PAH, having taken “Korargin”, patients has improved tolerance to phisical activity, FC PAH on WHO and hemodynamic parameters.
Chemoprevention of prostate cancer in TRAMP mice by Dibenzoylmethane (DBM)
Authors: Tin Oo Khor, Siwang Yu, Avantika Gopalakrishnan, Mou-Tuan Huang, Harold Newmark, Ah-Ng Tony Kong
Journal: Cancer Research (2008)

3053   Prostate cancer is the most commonly diagnosed cancer in men. Age, ethnicity and family history of disease are among risk factors for prostate cancer. Although localized prostate cancer is curable by radiation therapy or androgen ablation, the probability of metastatic progression with increase mortality rate is extremely high. Given the fact that the onset of prostate cancer is relatively late, prevention may be the best approach to fight the disease. Dibenzoylmethane (DBM), a minor beta-diketone constituent of licorice, has been shown to exhibit anti-neoplastic effects in prostate cancer cell lines by induction of cell cycle arrest and regulation of androgen receptor (AR) expression. In the present study, we investigated the chemopreventive efficacy of DBM in the transgenic adenocarcinoma mouse prostate (TRAMP) mice. At 8 weeks of age, mice were fed control or 1% DBM-supplemented diets until 24 weeks of age. Our results show that DBM-fed mice had a lower incidence of high grade prostatic intraepithelial neoplasia (PIN). Expressions of phospho-retinoblastoma (p-Rb), c-myc, cyclin-D1 and cyclin-A were significantly reduced in prostate tissue from DBM treated group as compared to tumors from control animals. Our findings suggest that oral DBM blocks the growth and progression of prostate cancer in TRAMP mice via modulation of tumor cell cycle regulation and therefore merits its consideration for future clinical intervention of human prostate cancer (Supported in part by NIH R01-CA118947).
Abstract 3684: Nanoparticle-encapsulated piperine and piperlongumine inhibit breast cancer cell growth and metastatic activity
Authors: Javad Ghassemi-Rad, David W. Hoskin
Journal: Cancer Research (2015)

Abstract Breast cancer is the second leading cause of cancer-related deaths among women in Canada and the United States. Metastatic disease is the primary cause of death, despite recent advances in breast cancer treatment strategies and personalized medicine. Novel anti-cancer therapeutics are therefore urgently needed to increase the lifespan of breast cancer patients and prevent metastasis. Piperine (PIP) and piperlongumine (PL), two of the major alkaloids in pepper spices, show inhibitory effects on breast cancer cell growth in vivo and in vitro; however, their lipophilicity has restricted possible clinical application. The encapsulation of these phytochemicals in biodegradable nanoparticles is predicted to increase their water solubility and bioavailability. The goal of this study was first, to optimize a method for the preparation of PIP- and PL-containing polymeric nanoparticles, and second, to explore the inhibitory effects of nanoparticle-encapsulated PIP and PL on breast cancer cell growth and metastatic activity. In contrast to the single oil-in-water emulsion method, PIP- and PL-nanoparticles prepared by the thin-film hydration method were more spherical and showed a uniform size distribution. PIP- and PL- containing nanoparticles decreased the viability of MDA-MB-231 and MDA-MB-468 triple-negative breast cancer cells to the same extend as free PIP and PL. In addition, a noncytotoxic concentration of PIP- and PL-containing nanoparticles inhibited the in vitro migration and invasion of triple-negative breast cancer cells. These findings demonstrate that the encapsulation of PIP and PL within polymeric nanoparticles is possible without compromising the bioactivity of these phytochemicals. PIP- and PL-nanoparticles therefore warrant further investigation in mouse models of breast cancer to establish their utility in the treatment of breast cancer. Citation Format: Javad Ghassemi-Rad, David W. Hoskin. Nanoparticle-encapsulated piperine and piperlongumine inhibit breast cancer cell growth and metastatic activity. [abstract]. In: Proceedings of the 106th Annual Meeting of the American Association for Cancer Research; 2015 Apr 18-22; Philadelphia, PA. Philadelphia (PA): AACR; Cancer Res 2015;75(15 Suppl):Abstract nr 3684. doi:10.1158/1538-7445.AM2015-3684
MicroRNAs 143 and 145 are onco-related miRNAs in human colon cancers
Authors: Yukihiro Akao, Yoshihito Nakagawa, Yukio Kitade, Tomoki Naoe
Journal: Clinical Cancer Research (2008)

A11   MicroRNAs (miRNAs) are endogenous small non-coding RNAs (20-23 nucleotides) that negatively regulate gene expression at the translational level by base pairing to the 39 untranslated region of target messenger RNAs. More than 500 of miRNAs have been identified in humans and are evolutionally conserved from plants to animals. It has been revealed that miRNAs regulate various biological processes such as development, cell differentiation, cell proliferation, and cell death. Inappropriate expression of miRNAs has been found in cancer. Especially, the expression level of miRNAs that act like anti-oncogenes is frequently reduced in cancers because of chromosome aberrations. Here, we found that the expression of miRs-143 and -145, which are transcribed in the same primary miRNA, was down-regulated frequently in human colon cancers (miR-143; 45/62 (73%) cases, miR-145; 49/62 (79%) cases) and commonly in the other kinds of cancer cell lines tested. The transfection of each modified mature miRNA into the cells demonstrated a significant growth inhibition in human colon cancer DLD-1 and SW480 cells, and the target gene of miR-143 was determined to be ERK5 that is a growth-related MAPK. Since the presence of genomic loci (5q32) of the miRNAs was confirmed by PCR in the cell lines and the miRNAs were up-regulated during growth suppression, the transcription of the miRNAs seemed to be commonly disturbed in cancer cells. The anti-cancer effect of the miRNAs was demonstrated in mouse model. The available data suggest that miRNAs would be potentially useful as diagnostic and therapeutic tools.
Abstract 2101: Left Superior Vena Cava Isolation In Patients Undergoing Pulmonary Vein Antrum Isolation: Impact On Atrial Fibrillation Recurrence
Authors: Claude S Elayi, Tamer S Fahmy, Oussama M Wazni, Dimpi Patel, Mauricio Arruda, Richard Hongo, Hao Steven, Salwa Beheiry, Mohamed Khan, Mohamed Kanj, Chi Keong Ching, Luigi Di Biase, Dhanunjaya Lakkireddy, Rong Bai, Shane Bailey, Kenneth Civello, Jennifer Cummings, Thomas Dresing, David Martin, David Burkhardt, Robert Schweikert, Walid Saliba, Andrea Natale
Journal: Circulation (2006)
Stiffness of systemic arteries in patients with myocardial infarction. A noninvasive method to predict severity of coronary atherosclerosis.
Authors: T Hirai, S Sasayama, T Kawasaki, S Yagi
Journal: Circulation (1989)

The static elastic properties of arterial tree (abdominal aorta and common carotid artery) were studied in 19 normal subjects and in 49 patients with myocardial infarction with an ultrasonic phase-locked echo-tracking system that allows continuous transcutaneous measurement of the arterial diameter. The stiffness index beta, which represented the mechanical properties in the arterial wall, was calculated from the relation between systemic blood pressure and the diameter of the artery. Patients with myocardial infarction underwent coronary angiography in their convalescent period to determine involved vessels. In 11 patients, coronary artery was patent; 15 patients had one-vessel disease, 12 had two-vessel disease, and the remaining 11 patients had three-vessel disease. In normal subjects, increasing age was associated with an increase in arterial stiffness. An average value of the stiffness index of the abdominal aorta was 8.58 +/- 3.02 (mean +/- SD) and that of common carotid artery was 9.17 +/- 2.22. In patients with three-vessel disease, these values were significantly higher (22.37 +/- 4.29 in abdominal aorta and 13.17 +/- 4.56 in common carotid artery) than those in normal subjects. Stiffness index of patients with two- or one-vessel disease was also increased but lower than those in patients with three-vessel disease (p less than 0.05). Forty-four of 49 patients with infarction had an arterial stiffness index of abdominal aorta higher than the 95% confidence limits of the normal data (p less than 0.05). Twenty-eight patients were outside the nomogram of common carotid artery (p less than 0.05). The mechanical properties of these elastic arteries provided sufficiently reliable information on changes caused by atherosclerosis.
Abstract 11617: Time-Dependent Changes of Ventricular Repolarization and Arrhythmia in Patients with Cardiac Resynchronization Therapy
Authors: Mitsuaki Itoh, Akihiro Yoshida, Asumi Takei, Mitsuru Takami, Satoko Tanaka, Kimitake Imamura, Ryudo Fujiwara, Suzuki Atsushi, Tomoyuki Nakanishi, Soichiro Yamashita, Ken-ichi Hirata
Journal: Circulation (2011)

Background; Cardiac resynchronization therapy (CRT) improves the clinical status of patients with congestive heart failure, but there is some evidence that left ventricular (LV) pacing may have pro...
Abstract 16314: Identification of MicroRNAs Inducing Adult Cardiomyocyte Proliferation
Authors: Raghav Pandey, Laeia Jackson, Gang Ma, Rafeeq p Ahmed
Journal: Circulation (2014)

Background: Even though neonatal cardiomyocytes (NCM) proliferate robustly, adult cardiomyocytes (ACM) have very little proliferative potential. By functional screening of 875 microRNAs (miRs) Eulalio et al 2012 identified 46 miRs which induce proliferation of NCMs by more than 35%. Additional studies by Mahmood et al 2013 have identified Meis1 as the major player that controls ACM cell cycle. We hypothesize that the proliferation inducing potential of miRs may vary between NCMs and ACMs and some of these miRs may induce proliferation through Meis1 regulation.

Methods and Results: ACM were isolated from male rats aged 4-6 months and transfected with miR mimics for cel-67 (control) and 24 of the top NCM proliferation inducing miRs individually. Edu was administered for 4 days starting day 1 after transfection. Cells were fixed on day 5 and immuno-stained. Proliferating cardiomyocytes were identified by co-staining of TnI and Edu and the percentage was calculated in each group. Eighteen of the 24 miRs induced significant proliferation of ACMs . The most significant of them with more than 7% increase in ACM proliferation were miR-302b-5p (7.8±0.6), miR-1910 (9.8±0.76), miR-548c-3p (11.9±2.7), miR-2053 (10.1±0.4), miR-936 (11.6±3.4), miR-1825 (54±5.2), miR-509 (7.1±0.62), miR-590 (11.5±1.1) and miR-23b-3p (12.7±0.35). Of these we identified 3 miRs (miR-548c-3p, miR-509-3p and miR-23b) to have binding site on the 3’UTR of Meis1 and simultaneously showing an increase in proliferation. Meis1 has been established as a critical transcriptional regulator of CM proliferation through activation of CDK inhibitors.

Conclusion: To the best of our knowledge this is the first study to identify a panel of miRs inducing ACM proliferation. Delivering these miRs to the infarcted region is a promising approach and has the potential to regenerate the ischemic heart by inducing proliferation of CMs surrounding the infarct zone.
A brief test for measuring malingering in schizophrenic individuals
Authors: Rex J. Beaber, Albert Marston, Joe Michelli, Mark J. Mills
Journal: American Journal of Psychiatry (1985)

The M Test, a brief test for measuring malingering of schizophrenic illness, contains true-false items describing actual symptoms of schizophrenia, bizarre attitudes and beliefs, and fake symptoms. Normal subjects rarely endorsed any of the items. The responses of genuinely ill schizophrenic inpatients were compared with those of normal subjects who had been asked to fake malingering after being educated about the symptoms of schizophrenia and forewarned about the purpose of the test. The test significantly discriminated between genuinely ill patients and malingerers. The test correctly identified 87.3% of the schizophrenic subjects and 78.2% of the malingering normal subjects.
Coercive persuasion (brainwashing), religious cults, and deprogramming
Authors: J T Ungerleider, D K Wellisch
Journal: American Journal of Psychiatry (1979)

Psychiatric interviews and psychological testing were conducted with 50 members of former members of a variety of religious cults who contacted the authors about the issue of deprogramming. The subjects were divided into four groups: cult members who feared deprogramming, those who had returned to the cult after deprogramming, ex-cult members who had left after deprogramming, and those who had left without deprogramming. There were significant differences between these groups on length of time in the cult, perception of and resistance toward the deprogramming experience, status of parental marriage, and who became a deprogrammer. No evidence of insanity or mental illness in the legal sense was found.
Alcohol Septal Ablation for the Treatment of Hypertrophic Obstructive Cardiomyopathy
Authors: Sherif F. Nagueh, Bertron M. Groves, Leonard Schwartz, Karen M. Smith, Andrew Wang, Richard G. Bach, Christopher Nielsen, Ferdinand Leya, John M. Buergler, Steven K. Rowe, Anna Woo, Yolanda Munoz Maldonado, William H. Spencer
Journal: Journal of the American College of Cardiology (2011)
Is screening for essential hypertension in children essential?
Authors: Julian Tudor Hart
Journal: BMJ (2008)

Vitamin D deficiency is widespread in Scotland I agree with Holick 1 and Sievenpiper et al 2 about the urgent need to highlight the neglected subject of vitamin D deficiency in the United Kingdom.We have found in our general practice in Edinburgh a (to us) surprisingly high prevalence of gross vitamin D deficiency.The deficiency affects not only our South Asian patients but also a considerable number of those with white skin colour.Between 2005 and 2007, blood samples were taken from 99 patients aged 15-85.We included patients suspected of having a possible vitamin D deficiency: patients of South Asian origin or other ethnic minorities, patients with vague musculoskeletal symptoms or overweight, patients taking antiepileptic drugs, patients using sunscreen or make up, housebound patients, and patients with little exposure to sunlight.The figure shows our as yet unpublished results.According to the definitions of most vitamin D researchers, insufficient vitamin D concentrations are those below 75 nmol/l.In our sample only 2% had a sufficient vitamin D concentration.Measurements below 25 nmol/l are defined as severe deficiency; in our sample, the proportion was 47%.We select the letters for these pages from the rapid responses posted on bmj.com favouring those received within five days of publication of the article to which they refer.Letters are thus an early selection of rapid responses on a particular topic.
Ebola Virus Transmission
Authors: Joan Stephenson
Journal: JAMA (2004)

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Abstract P368: Genome Wide Association Study Identifies Susceptibility Loci for Coronary Artery Calcium in Smokers
Authors: Sharon M Lutz, Michael H Cho, Gregory Kinney, Katherine Pratte, Richard Casaburi, Edwin Silverman, Matthew Budoff, John E Hokanson
Journal: Circulation (2015)

Introduction: Coronary artery calcium (CAC) is a measure of coronary atherosclerosis, which is strongly associated with the presence of coronary artery disease and predicts future coronary disease events and mortality. CAC is a heritable trait. Numerous candidate gene studies and more recently genome-wide association studies (GWAS) have identified susceptibility loci for CAC. In addition, cardiovascular disease risk factors such as smoking are associated with CAC. Hypothesis: We hypothesized that we would identify new genetic loci and replicate known genomic regions for CAC by performing a GWAS among heavy smokers in the COPDGene study, a multi-center observational study designed to identify genetic factors associated with risk of COPD. Methods: We conducted a GWAS of CAC in COPDGene, a study of 10,192 current and former smokers with at least 10 pack-years of smoking history. CAC was measured from chest CT scans using an established protocol and was available in 8,739 individuals (6,150 non-Hispanic Whites and 2,589 African Americans). The analysis was performed using PLINK v1.07 adjusting for genetic ancestry using principal components as well as and cardiovascular disease risk factors (age, gender, BMI, smoking status, pack-years of smoking history, diabetes, high blood pressure, steroid use, high cholesterol, and presence of a coronary stent). Results: Using the log transformation of CAC plus 1 as the outcome, there were 9 single nucleotide polymorphisms (SNPs) on chromosome 9 [CDKN2B-AS1] that reached genome wide significance in non-Hispanic Whites, with the most significant result being rs10757272 (p = 3.572e-11). Additional top loci that have been previously identified were rs9349379 on chromosome 6 [PHACTR1] (p =8.760e-08) and rs1263982 on chromosome 17 [CA10] (p =4.654e-06). Among African Americans, no genome-wide significant associations were identified; however, one of the top findings was rs7412 on chromosome 19 [APOE] (p = 1.597e-06). Conclusions: This study confirms genome wide significance for CAC for CDKN2B-AS1 on chromosome 9 among non-Hispanic Whites. This is the major GWAS signal for clinically manifested coronary artery disease. Among African Americans, we found a suggestive association signal in the APOE gene. In conclusion, genetic susceptibility for atherosclerosis is evident, even among individuals with a substantial smoking burden. This highlights the importance of both genetics and behavioral risk factors in the susceptibility to atherosclerosis.
Pegylated, full-length, recombinant factor VIII for prophylactic and on-demand treatment of severe hemophilia A
Authors: Barbara A. Konkle, Oleksandra Stasyshyn, Pratima Chowdary, David H. Bevan, Tim Mant, Midori Shima, Werner Engl, Jacqueline Dyck-Jones, Monika Fuerlinger, Lisa Patrone, Bruce Ewenstein, Brigitt Abbuehl
Journal: Blood (2015)