THROMBOTIC THROMBOCYTOPENIC PURPURA: REPORT OF A CASE AND REVIEW OF THE LITERATURE
Authors: J W KINGSLEY, R B AQUINO
Journal: Annals of Internal Medicine (1958)

Case Reports1 October 1958THROMBOTIC THROMBOCYTOPENIC PURPURA: REPORT OF A CASE AND REVIEW OF THE LITERATUREJ. W. KINGSLEY JR., M.D., REBECCA B. AQUINO, M.D.J. W. KINGSLEY JR., M.D.Search for more papers by this author, REBECCA B. AQUINO, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-49-4-934 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThrombotic thrombocytopenic purpura is an uncommon condition characterized by thrombocytopenia, hemolytic anemia and widespread occlusions of arterioles and capillaries. The vascular occlusions affect the central nervous system to a particularly great degree, producing diverse neurologic signs and symptoms. The earliest report of this disease was by Moschcowitz in 1925 under the title, "An Acute Febrile Pleochromic Anemia with Hyaline Thrombosis of the Terminal Arterioles and Capillaries."1Several other descriptive terms were employed until 1947, when "thrombotic thrombocytopenic purpura" was proposed by Singer et al.2Although this designation fails to emphasize the hemolytic factor, it is the term most commonly used...Bibliography1. Moschcowitz E: An acute febrile pleochromic anemia with hyaline thrombosis of the terminal arterioles and capillaries, Arch. Int. Med. 36: 89, 1925. CrossrefGoogle Scholar2. SingerBornsteinWile KFPSA: Thrombotic thrombocytopenic purpura: hemorrhagic diathesis with generalized platelet thromboses, Blood 2: 542, 1947. CrossrefMedlineGoogle Scholar3. Gore I: Disseminated arteriolar and capillary platelet thrombosis; morphologic study of its histogenesis, Am. J. Path. 26: 155, 1950. MedlineGoogle Scholar4. MeachamOrbisonHeinleSteeleSchaefer GCJLRWHJJA: Thrombotic thrombocytopenic purpura: disseminated disease of arterioles, Blood 6: 706, 1951. CrossrefMedlineGoogle Scholar5. Orbison JL: Morphology of thrombotic thrombocytopenic purpura with demonstration of aneurysms, Am. J. Path. 28: 129, 1952. MedlineGoogle Scholar6. March HW: The diffuse vascular lesion of so-called "thrombotic thrombocytopenic purpura," Circulation 10: 43, 1954. CrossrefMedlineGoogle Scholar7. AdelsonHeitzmanFennessey EEJJF: Thrombohemolytic thrombocytopenic purpura, Arch. Int. Med. 94: 42, 1954. CrossrefGoogle Scholar8. Beigelman PM: Variants of the platelet thrombosis syndrome and their relationship to disseminated lupus, Arch. Path. 51: 213, 1951. Google Scholar9. SymmersGillett WSR: Polyarteritis nodosa, associated with malignant hypertension, disseminated platelet thrombosis, "wire-loop" glomeruli, pulmonary silicotuberculosis and sarcoidosis-like lymphadenopathy, Arch. Path. 52: 489, 1951. Google Scholar10. GitlowGoldmark SC: Generalized capillary and arteriolar thrombosis: report of two cases with a discussion of the literature, Ann. Int. Med. 13: 1046, 1939-40. LinkGoogle Scholar11. LazloAlvarezFeldman MHAF: The association of thrombotic thrombocytopenic purpura and disseminated lupus erythematosus: report of a case, Ann. Int. Med. 42: 1308, 1955. LinkGoogle Scholar12. GendelYoungKraus BRJMAP: Thrombotic thrombocytopenic purpura, Am. J. Med. 13: 3, 1952. CrossrefMedlineGoogle Scholar13. Barondess JA: Thrombotic thrombocytopenic purpura, Am. Jr. Med. 13: 294, 1952. CrossrefMedlineGoogle Scholar14. WileSturgeon SAP: Thrombotic thrombocytopenic purpura, Pediatrics 17: 882, 1956. MedlineGoogle Scholar15. BaehrKlempererSchifrin GPA: An acute febrile anemia and thrombocytopenic purpura with diffuse platelet thromboses of capillaries and arterioles, Tr. A. Am. Physicians 51: 43, 1936. Google Scholar16. Baez-VillasenorAmbrosius JK: Thrombotic thrombocytopenic purpura: report of a case with some unusual characteristics, Ann. Int. Med. 46: 378, 1957. LinkGoogle Scholar17. Singer K: Thrombotic thrombocytopenic purpura, Advances Int. Med. 6: 195, 1954. MedlineGoogle Scholar18. CooperStickneyPeaseBennett TJMGLWA: Thrombotic thrombocytopenic purpura, Am. J. Med. 13: 374, 1952. CrossrefMedlineGoogle Scholar19. GardnerMcElfreshHarrisDiamond FHAEJWLK: The effect of adrenocorticotrophic hormone (ACTH) in idiopathic acquired hemolytic anemia as related to the hemolytic mechanisms, J. Lab. and Clin. Med. 37: 444-457, 1951. MedlineGoogle Scholar20. NussbaumDameshek MW: Transient hemolytic and thrombocytopenic episode (? acute transient thrombohemolytic thrombocytopenic purpura) with probable meningococcemia, New England J. Med. 256: 448, 1957. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Detroit, Michigan*Received for publication April 9, 1957.From the Department of Medicine, Alexander Blain Hospital, Detroit, Michigan.Requests for reprints should be addressed to J. W. Kingsley, Jr., M.D., 18801 Ten Mile Rd., Roseville, Michigan. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byBIBLIOGRAPHYPurpura Fulminans in a Newborn BabyThrombotic thrombocytopenic purpura in pregnancy 1 October 1958Volume 49, Issue 4Page: 934-941KeywordsArteriolesCapillariesComaHemolytic anemiaHospital medicineNauseaParalysisSigns and symptomsThrombosisThrombotic thrombocytopenic purpura ePublished: 1 December 2008 Issue Published: 1 October 1958 PDF downloadLoading ...