tbuckley/cabot-search huggingface dataset:
A Controlled Trial of Multiphasic Screening
Authors: Donna M. Olsen, Robert L. Kane, Paul H. Proctor
Journal: New England Journal of Medicine (1976)

Abstract A clinical controlled trial was designed to determine the impact of Automated Multiphasic Health Testing on morbidity and attitudes. Three strata comprising 574 families (lower-income group enrolled in health maintenance organization, lower-income not enrolled in such a project, and a middle-income group employed by a utility company) were interviewed to obtain information on utilization, morbidity, health status, and attitudes. Sixty per cent of adults in each stratum were then screened. All families were interviewed again one year later. The only significant difference found between screened and non-screened subjects was an increase in nights hospitalized for screened subjects. Physicians were interviewed to determine what abnormalities were found and what treatment was required for project and privately referred patients of these physicians. Previously unknown abnormalities prompted retesting for confirmation in only 28 per cent of the cases and even less often led to treatment (15 per cent). (N Engl J Med 294:925–930, 1976)
Surgery in Viet Nam
Authors: David E. Thomas
Journal: JAMA (1971)

<h3>To the Editor.—</h3> I note with concern an ESSAY REVIEW entitled "Medicine Over There" by Dr. Alister Brass, published inThe Journal(<b>213:</b>1473, 1970). The article contains a long quotation from Eccles Smith's<i>Letters From a Vietnam Hospital</i>published a year ago, which reported on events of two or more years past. This quotation received an immoderate public notice shortly after publication, which most army medical men chose to ignore, because of its bias and its inaccuracy. What is gained by this repetition inThe Journal? When the writer described the open treatment of war wounds which he thought "went out in the 1914-1918 war" he described the only way to handle contaminated war wounds. But it is the inaccurate reporting which is particularly offensive. Our surgical consultant LTC Stuart S. Roberts (on leave from his surgery professorship at Ohio State University Medical School) reports on the<i>civilian</i>hospital
Analysis of the First-Year Cost of a Prostate Cancer Screening and Treatment Program in the United States
Authors: W. L. Lubke, S. A. Optenberg, I. M. Thompson
Journal: JNCI Journal of the National Cancer Institute (1994)

Journal Article Analysis of the First-Year Cost of a Prostate Cancer Screening and Treatment Program in the United States Get access William L. Lubke, William L. Lubke Department of Urology, Wilford Hall Medical CenterSan Antonio, Tex Search for other works by this author on: Oxford Academic PubMed Google Scholar Scott A. Optenberg, Scott A. Optenberg Department of Urology, Center for Health CareSan Antonio Search for other works by this author on: Oxford Academic PubMed Google Scholar Ian M. Thompson Ian M. Thompson Urology Surgery Service, Brooke Army Medical Center and the Center for Health Care Education and Studies, Army Medical DepartmentSan Antonio Correspondence to: Ian M. Thompson, M.D., Urology Surgery Service, Department of Surgery, Brooke Army Medical Center, Fort Sam Houston, TX 78234-6200. Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 86, Issue 23, 7 December 1994, Pages 1790–1792, https://doi.org/10.1093/jnci/86.23.1790 Published: 07 December 1994 Article history Received: 22 March 1994 Revision received: 24 August 1994 Published: 07 December 1994
Life-Threatening Complications of Sickle Cell Disease in Children
Authors: Myron L. Mills
Journal: JAMA (1985)

SINCE 1910, when sickle cell anemia (SCA) was first described by Dr James Herrick, a Chicago cardiologist, a prodigious amount of clinical and laboratory investigation has taken place in an effort to elucidate the pathogenesis, etiology, and treatment of SCA.<sup>1</sup>In 1949, Pauling and Itano<sup>2</sup>published their findings relating to the different electrophoretic properties of hemoglobin from patients with SCA. Later, in 1957, Ingram<sup>3</sup>published the results of his work detailing the biochemical defect in hemoglobin S. From the early 1950s to the present time, the sickle erythrocyte and hemoglobin S molecule have been studied by sophisticated techniques that have revealed their structure and function at the molecular level. Techniques employed for these studies have included low-resolution x-ray crystallography, electron microscopy with image reconstruction, hemoglobin S polymerization kinetics, high-resolution proton nuclear magnetic resonance spectroscopy, and fiber x-ray diffraction. The basic defect in hemoglobin S is the substitution
Abrasive Cytology of the Pancreatic and Biliary Duct in Man
Authors: S. Weidenhiller, H. Fluegel, W. Rösch
Journal: Endoscopy (1975)

Using a specially designed Fogarthy-catheter running through the conventional ERCP tube sufficient cytological material can be obtained from the pancreatic and common bile duct without complications. The method seems very useful in suspicious strictures or complete obstruction of the ductal system by malignancy.
Jimson Weed Seeds
Authors: ROBERT W. MILLER
Journal: Annals of Internal Medicine (1975)

Comments1 December 1975Jimson Weed SeedsROBERT W. MILLER, M.D.ROBERT W. MILLER, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-83-6-905_1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: Mikolich, Paulson, and Cross (1) recently called attention to an anticholinergic syndrome due to ingestion of Jimson seeds by teen-agers for a hallucinogenic effect. Their report brings to mind other misadventures with Jimson weed. Roueché (2) described the poisoning of five persons who shared a meal that included home-grown tomatoes from stalks grafted onto a Jimson weed plant. Both plants are members of the nightshade family. The graft was made to produce a frost-resistant tomato that would ripen in late fall. Unfortunately, the fruit was filled with belladonna alkaloids.In an excellent but obscure five-paragraph report, three...References1. MIKOLICH J, PAULSON G, and CROSS C: Acute anticholinergic syndrome due to Jimson seed ingestion. Clinical and laboratory observation in six cases. Ann Intern Med 83:321-325, 1975 LinkGoogle Scholar2. ROUECHÉ B: Something a little unusual, in Annals of Epidemiology, edited by ROUECHÉ B. Boston, Little, Brown and Company, 1967, pp. 285-302 Google Scholar3. GOLDEY J, DICK D, and PORTER W: Cornpicker's pupil. A clinical note regarding mydriasis from Jimson weed dust (stramonium). Ohio State Med J 62:921, 1966 Google Scholar1. MAHLER D: The Jimson weed high. JAMA 231:138, 1975 CrossrefMedlineGoogle Scholar2. ODERDA G: Jimson weed. JAMA 232:597, 1975 CrossrefMedlineGoogle Scholar3. ORR R: Reversal of Datura stramonium delirium with physostigmine: report of three cases. Anesth Analg (Cleve) 54:158, Jan-Feb 1975 CrossrefMedlineGoogle Scholar4. New drug on the scene? Newsweek, p. 13, March 10, 1975 Google Scholar5. CASTANEDA C: The Teachings of Don Juan: A Yaqui Way of Knowledge. University of California Press, 1968 Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: ROBERT W. MILLER, M.D.Affiliations: Epidemiology Branch National Cancer Institute Bethesda, Maryland 20014 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byIn vivo expression of in vitro anticoccidial activity 1 December 1975Volume 83, Issue 6Page: 905-905KeywordsAlkaloidsFallsIngestion ePublished: 1 December 2008 Issue Published: 1 December 1975 PDF downloadLoading ...
Brachial Artery Flow-Mediated Dilation and Asymmetrical Dimethylarginine in the Cardiovascular Risk in Young Finns Study
Authors: Markus Juonala, Jorma S.A. Viikari, Georg Alfthan, Jukka Marniemi, Mika Kähönen, Leena Taittonen, Tomi Laitinen, Olli T. Raitakari
Journal: Circulation (2007)

Background— Elevated asymmetrical dimethylarginine (ADMA) is a novel risk factor for atherosclerosis that may impair endothelial function by interfering with endothelial nitric oxide synthesis. To gain insight into the effects of ADMA on systemic endothelial function, we examined the association between ADMA and brachial artery flow-mediated dilation (FMD) in a large population of young adults. Methods and Results— Plasma ADMA and brachial FMD, as well as conventional cardiovascular risk factors, were measured in 2096 white adults aged 24 to 39 years. In univariate analysis, ADMA was inversely correlated with FMD ( r =−0.07, P =0.003). The inverse association between ADMA and FMD remained significant in a multivariable regression model adjusted for age, sex, conventional cardiovascular risk factors, estimated glomerular filtration rate, and brachial artery baseline diameter (β±SE −1.56±0.62%, P =0.01). Conclusions— We conclude that elevated plasma ADMA concentrations are associated with decreased brachial FMD responses in healthy adults. These data provide evidence at the population level that ADMA levels are associated with endothelial function.
Student Protest — Fit to Live (and to Drive) — No More Pay
Authors: John Lister
Journal: New England Journal of Medicine (1968)

STUDENT demonstrations are no new phenomenon, but at present the student population in many parts of the world appears to be almost on the threshold of anarchy.There have been minor disturbances in many British universities, but the most serious occurred in the new University of Essex. The occasion that triggered the trouble was a lecture to the Chemistry Society by Dr. T. D. Inch, a lecturer from the Government Chemical Defence Experimental Establishment. During the lecture a group of about 150 anti-war students entered and read an indictment of some of the Establishment's activities in research for chemical and . . .
The environment as an etiologic factor in autism: a new direction for research.
Authors: E A London
Journal: Environmental Health Perspectives (2000)

Autism is one of a group of developmental disorders that have devastating lifelong effects on its victims. Despite the severity of the disease and the fact that it is relatively common (15 in 10,000), there is still little understanding of its etiology. Although believed to be highly genetic, no abnormal genes have been found. Recent findings in autism and in related disorders point to the possibility that the disease is caused by a gene-environment interaction. Epidemiologic studies indicate that the number of cases of autism is increasing dramatically each year. It is not clear whether this is due to a real increase in the disease or whether this is an artifact of ascertainment. A new theory regarding the etiology of autism suggests that it may be a disease of very early fetal development (approximately day 20-24 of gestation). This theory has initiated new lines of investigation into developmental genes. Environmental exposures during pregnancy could cause or contribute to autism based on the neurobiology of these genes.
Chronic Myelogenous Leukemia Complicated by Hypofibrinogenemia
Authors: Gregory R. Favis
Journal: JAMA (1978)

<h3>To the Editor.—</h3> Disseminated intravascular coagulation with hypofibrinogenemia is an unusual complication of acute leukemia, especially acute promyelocytic leukemia.<sup>1</sup>However, hypofibrinogenemic bleeding as a complication of chronic myelogenous leukemia (CML) must be a rare event, since this has been reported only once previously.<sup>2</sup>We report an additional case of CML in which hypofibrinogenemia appears to have played a major role in the patient's death. <h3>Report of a Case.—</h3> A 57-year-old man was admitted to the Philadelphia Veterans Administration Hospital complaining of three days of nausea and vomiting, weakness, malaise, and an exacerbation of a previously troublesome frontal headache. He had known CML (Philadelphia chromosome positive) for three years, during which he manifested sharp fluctuations in his peripheral WBC counts (20,000/cu mm to 150,000/cu mm) in the absence of chemotherapy. On admission his medications included allopurinol and hydrochlorothiazide. Physical examination showed an ill-appearing man. His blood pressure was 170/90
Endoloop ligation (“loop-and-let-go”) of a large ileal lipoma by balloon-assisted enteroscopy
Authors: R. Veloso, R. Pinho, A. Rodrigues, T. Pais, C. Fernandes, J. Carvalho, J. Fraga
Journal: Endoscopy (2012)

A 72-year-old man presented to our gastroenterology outpatient clinic with chronic abdominal pain, bloating, and past episodes of transient small-bowel obstruction. A computed tomography (CT) enterogram revealed a large, pedunculated subepithelial polyp in the distal ileum ([Fig. 1]).
Syncope and Heart Block
Authors: RAUL E. FALICOV
Journal: Annals of Internal Medicine (1975)

Comments and Corrections1 March 1975Syncope and Heart BlockRAUL E. FALICOV, M.D., WILLIAM FOX, M.D.RAUL E. FALICOV, M.D.Search for more papers by this author, WILLIAM FOX, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-82-3-430 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: With reference to the valuable paper by Dhingra and colleagues (Ann Intern Med 81:302-306, 1974), we wish to ask three questions, which we believe are pertinent, and offer some comments:1. Was idiopathic hypertrophic subaortic stenosis excluded in those patients with unexplained syncope? The clinical presentation of idiopathic hypertrophic subaortic stenosis may be one of recurrent syncopal episodes with or without angina pectoris, and the classical signs may be subtle, intermittent, or absent, especially in the presence of intermittent obstruction to the left ventricular outflow. Echocardiography and left heart catheterization and angiography are on occasion the only...References1. SPODICK D: Hypertrophic obstructive cardiomyopathy of the left ventricle. Cardiovasc Clin 4:133-165, 1972 MedlineGoogle Scholar2. JOHNSONMESSERSHREENIVAS RA: Prognosis in bundle branch. II. Factors influencing the survival period in left bundle branch block. Am Heart J 45:225, 1951 CrossrefGoogle Scholar3. SMITHHAYES SW: The prognosis of complete left bundle branch block. Am Heart J 80:157, 1965 CrossrefGoogle Scholar4. ROSEMBAUMELIZARILEVI MMR: Paroxysmal atrioventricular block related to hyperpolarization and spontaneous diastolic depolarization. Chest 63:678, 1973 CrossrefMedlineGoogle Scholar1. DENESDHINGRAWU PRD: The H-V interval in patients with bifascicular block (RBBB and LAD) : clinical, electrocardiographic and electrophysiologic correlations. Am J Cardiol. In press for 1975 Google Scholar2. ROSENEHSANIRAHIMTOOLA KAS: H-V interval in left bundle branch block; clinical electrocardiographic correlations. Circulation 46:717-723, 1972 CrossrefMedlineGoogle Scholar3. ROSEN K: Catheter recording of His bundle electrograms. Mod Concepts Cardiovasc Dis 42:23-28, 1973 MedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Department of Medicine Cardiology The University of Chicago 950 East 59th Street Chicago, Illinois 60637 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 March 1975Volume 82, Issue 3Page: 430-431KeywordsAnginaAngiographyCatheterizationEchocardiographyHeartStenosisSyncope Issue Published: 1 March 1975 PDF downloadLoading ...
Diagnostic Value of Tl-201 and Three-Phase Bone Scintigraphy for Bone and Soft-Tissue Tumors
Authors: YOSHIHIRO NISHIYAMA, YUKA YAMAMOTO, YOSHIHIRO TOYAMA, KATASHI SATOH, MOTOOMI OHKAWA, MASATADA TANABE
Journal: Clinical Nuclear Medicine (2000)

Although TI-201 is highly sensitive for detecting bone and soft-tissue tumors, its uptake is not specific for malignant lesions. This study assessed the differentiation of malignant and benign lesions and evaluated the sensitivity, specificity, and accuracy of TI-201 imaging and three-phase bone scans.Forty bone and soft-tissue tumors (16 malignant and 24 benign) were evaluated. TI-201 static images were acquired 10 minutes (early) and 2 hours (delayed) after injection of the radionuclide. Within 14 days, three-phase bone scintigraphy was performed using Tc-99m HMDP with the patient in the same position. The count ratio of the lesion compared with the normal contralateral or adjacent site (L:N ratio) was measured.With TI-201 scintigraphy, mean (+/- SD) values of early and delayed L:N ratios were 3.36 +/- 1.25 and 2.88 +/- 1.20, respectively, in malignant lesions; and 1.88 +/- 1.14 and 1.48 +/- 0.76, respectively, in benign lesions. TI-201 accumulation in benign lesions was significantly less than that of malignancies on early and delayed images. However, an overlap of both ratios between malignant and benign lesions was seen. No such significance was detected on three-phase bone scintigraphy (L:N ratios of malignant and benign tumors were 2.57 +/- 1.22 and 2.24 +/- 2.11, respectively, for blood flow imaging; 2.41 +/- 0.78 and 2.26 +/- 1.54, respectively, for blood pool imaging; and 2.80 +/- 2.10 and 2.89 +/- 4.55, respectively, for bone imaging). When we assumed that the tumor was malignant when the delayed TI-201 L:N ratio exceeded the blood pool phase L:N ratio with bone scintigraphy, the sensitivity rate was 81%, specificity rate was 100%, and accuracy rate was 93%.TI-201 imaging for bone and soft-tissue tumors was better than three-phase bone scintigraphy alone but was not good enough to clearly differentiate malignant lesions from benign ones. TI-201 scintigraphy, performed in combination with three-phase bone scintigraphy, may be superior to either one of the two imaging procedures alone for bone and soft-tissue tumor diagnosis.
Long-Term Outcomes of Out-of-Hospital Cardiac Arrest after Successful Early Defibrillation
Authors: T. Jared Bunch, Roger D. White, Bernard J. Gersh, Ryan A. Meverden, David O. Hodge, Karla V. Ballman, Stephen C. Hammill, Win-Kuang Shen, Douglas L. Packer
Journal: New England Journal of Medicine (2003)

Mortality after out-of-hospital cardiac arrest from ventricular fibrillation is high. Programs focusing on early defibrillation have improved the rate of survival to hospital discharge. We conducted a population-based analysis of the long-term outcome and quality of life of survivors.All patients who had an out-of-hospital cardiac arrest between November 1990 and January 2001 who received early defibrillation for ventricular fibrillation in Olmsted County, Minnesota, were included. The survival rate was compared with that of an age-, sex-, and disease-matched (2:1) control population of residents who had not had an out-of-hospital cardiac arrest and with that of age- and sex-matched controls from the general U.S. population. The quality of life was assessed with use of the Medical Outcomes Study 36-item Short-Form General Health Survey (SF-36) and compared with U.S. population norms.Of 200 patients who presented with an out-of-hospital cardiac arrest with ventricular fibrillation, 145 (72 percent) survived to hospital admission (7 died in the emergency department) and 79 (40 percent) were neurologically intact (good overall capability or moderate overall disability) at discharge. The mean (+/-SD) length of follow-up was 4.8+/-3.0 years. Nineteen patients died after discharge from the hospital. The expected five-year survival rate (79 percent) was identical to that among age-, sex-, and disease-matched controls (P=0.68) but lower than that among the age- and sex-matched U.S. population (86 percent, P=0.02). Fifty patients completed SF-36 surveys at the end of follow-up, and the majority had a nearly normal quality of life, with the exception of reduced vitality.Long-term survival among patients who have undergone rapid defibrillation after out-of-hospital cardiac arrest is similar to that among age-, sex-, and disease-matched patients who did not have out-of-hospital cardiac arrest. The quality of life among the majority of survivors is similar to that of the general population.
Shortening the 4-Hour Gastric-Emptying Protocol
Authors: Dacian V. Bonta, Ho Y. Lee, Harvey A. Ziessman
Journal: Clinical Nuclear Medicine (2011)

A standardized 4-hour gastric-emptying protocol has been recommended by a consensus panel. However, a study length of 4 hours may be inconvenient. The purpose of this investigation was to determine if the percent emptying at 2 hours could predict abnormal or normal results at 4 hours.Our data consist of 2 distinct patient groups, containing 174 and 158 patients, respectively. All patients were given a standardized meal according to the Tougas et al protocol. Percent gastric emptying was measured at 1, 2, 3, and 4 hours (or until gastric emptying was equal to or more than 90%). The sensitivity, specificity, and the likelihood ratios of the 2-hour cutoffs were determined using the 4-hour data as the standard. We have estimated the accuracy and percent of studies stopped at 2 hours, resulting from various "definitely normal" and "definitely abnormal" threshold combinations.Using gastric emptying of less than 35% at 2 hours for diagnosis of delayed gastric emptying, and emptying at 2 hours greater than 55% for a diagnosis of normal gastric emptying yielded accuracies of 0.966 and 0.949 in the 2 datasets, respectively, compared with the Tougas standard values. The observed 2-hour gastric-emptying values would have allowed early termination in 79% and 78% of the studies, respectively.Adopting criteria for the termination of gastric-emptying study at 2 hours in selected patients yields significant reductions in the average length of a gastric-emptying study, while maintaining study accuracy.
Preregistration year: some background.
Authors: P Rhodes
Journal: BMJ (1982)

The routine estimation of large numbers of serum folic acid and vitamin B<sub>12</sub> levels using the Baird and Tatlock<sup>1</sup> Analmatic clinical system is described and the method evaluated. Precision, accuracy, and carryover are shown to be at acceptable levels, and the advantages and disadvantages of the use of the system are discussed. It is considered that with some modifications the Analmatic system offers a reliable and labour-saving method of carrying out considerable numbers of routine microbiological assays.
Factor VIII Products and Inhibitor Development in Severe Hemophilia A
Authors: Samantha C. Gouw, Johanna G. van der Bom, Rolf Ljung, Carmen Escuriola, Ana R. Cid, Ségolène Claeyssens-Donadel, Christel van Geet, Gili Kenet, Anne Mäkipernaa, Angelo Claudio Molinari, Wolfgang Muntean, Rainer Kobelt, George Rivard, Elena Santagostino, Angela Thomas, H. Marijke van den Berg
Journal: New England Journal of Medicine (2013)

For previously untreated children with severe hemophilia A, it is unclear whether the type of factor VIII product administered and switching among products are associated with the development of clinically relevant inhibitory antibodies (inhibitor development).
Photoaging/photodamage and photoprotection
Authors: Charles R. Taylor, Robert S. Stern, James J. Leyden, Barbara A. Gilchrest
Journal: Journal of the American Academy of Dermatology (1990)

Exposure to sunlight can produce both acute and long-term effects. Acute changes include erythema, photosensitivity, and immunologic alterations. Long-term consequences include carcinogenesis and photoaging. All effects can be minimized by photoprotection. This article reviews the adverse effects of sun exposure and strategies to reduce photodamage. Exposure to sunlight can produce both acute and long-term effects. Acute changes include erythema, photosensitivity, and immunologic alterations. Long-term consequences include carcinogenesis and photoaging. All effects can be minimized by photoprotection. This article reviews the adverse effects of sun exposure and strategies to reduce photodamage.