THE USE OF CHELATING AGENTS IN THE TREATMENT OF ACUTE PORPHYRIA
Authors: J T GALAMBOS, L B PEACOCK
Journal: Annals of Internal Medicine (1959)

Case Reports1 April 1959THE USE OF CHELATING AGENTS IN THE TREATMENT OF ACUTE PORPHYRIAJOHN T. GALAMBOS, M.D., LAMAR B. PEACOCK, M.D.JOHN T. GALAMBOS, M.D.Search for more papers by this author, LAMAR B. PEACOCK, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-50-4-1056 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptRecent reports advocate the use of chelating agents in the treatment of porphyria hepatica. The following case is described to point out that the administration of a chelating agent may be followed by prompt and clear-cut worsening of the clinical state of the patient with acute intermittent porphyria (AIP).CASE REPORTA 50 year old white man had been working in a metal casket manufacturing company and had been exposed intimately to zinc metal and lead dust for approximately 17 years. He had felt well until December 1, 1956, when he began to have cramping abdominal pains and marked constipation....Bibliography1. PetersWoodsEichmanReese HASPLHH: The treatment of acute porphyria with chelating agents: a report of 21 cases, Ann. Int. Med. 47: 889, 1957. LinkGoogle Scholar2. PetersEichmanReese HAPLHH: Therapy of acute, chronic, and mixed hepatic porphyria patients with chelating agents, Neurology 8: 621, 1958. CrossrefMedlineGoogle Scholar3. Schroeder HA: Trace metals in chronic diseases, Advances Int. Med. 8: 259-303, 1956. MedlineGoogle Scholar4. GalambosDowda JTWF: Lead poisoning and porphyria, Am. J. Med., in press. Google Scholar5. Unpublished data. Google Scholar6. Crutcher J: personal communication. Google Scholar7. GibsonNeubergerScott KPAJJ The purification and properties of delta-aminolaevulic acid dehydrase, Biochem. J. 61: 618-628, 1955. CrossrefMedlineGoogle Scholar8. ValleeWackerBartholomayHoch BLWEAFFL: Zinc metabolism in hepatic dysfunction, New England J. Med. 257: 1055, 1957. CrossrefMedlineGoogle Scholar9. BrunstingMasonAldrich LAHLRA: Adult form of chronic porphyria with cutaneous manifestations: report of 17 additional cases, J. A. M. A. 146: 1207, 1951. CrossrefMedlineGoogle Scholar10. PerrySchroeder HMHA: Lesions resembling vitamin B complex deficiency and urinary loss zinc produced by ethylenediamine tetra-acetate, Am. J. Med. 22: 168, 1957. CrossrefMedlineGoogle Scholar11. Galambos JT: Porphyria cutanea tarda without skin lesion in an American Negro, Am. J. Med. 25: 315, 1958. CrossrefMedlineGoogle Scholar12. SchwartzZagaria SR: Studies of porphyrin metabolism: the effect of metals on coproporphyrin excretion, in Toxicology of uranium, A. T. Tannenbaum, Editor, 1951, McGraw-Hill, New York. Google Scholar13. Watson CJ: Some studies of nature and clinical significance of porphobilinogen, Arch. Int. Med. 93: 643-657, 1954. CrossrefGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Atlanta, Georgia*Received for publication November 17, 1958.From the Department of Medicine, Emory University School of Medicine, Atlanta. Georgia.Requests for reprints should be addressed to John T. Galambos, M.D., 69 Butler Street, Southeast, Atlanta 3, Georgia. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byPorphyria: Theories of Etiology and TreatmentCUTANEOUS PORPHYRIA. FAVOURABLE RESULTS IN TWELVE CASES TREATED BY CHELATIONPorphyric Psychosis and Chelation Therapy 1 April 1959Volume 50, Issue 4Page: 1056-1061KeywordsBronchoalveolar lavageCalciumCirrhosisConstipationDustEthylenediaminetetraacetic acidExcretionHypertensionPorphyriaZinc ePublished: 1 December 2008 Issue Published: 1 April 1959 PDF downloadLoading ...