tbuckley/cabot-search huggingface dataset:
Results of semen cryopreservation in young men with testicular carcinoma and lymphoma.
Authors: E Reed, W G Sanger, J O Armitage
Journal: Journal of Clinical Oncology (1986)

Sixty-two young men with testicular carcinoma (31 patients) or lymphoma (31 patients) were referred for semen analysis and possible cryopreservation before systemic therapy. Seventy-seven percent of the patients, 24 patients with testicular carcinoma and 24 patients with lymphoma, had semen with a decreased chance for fertility (ie, sperm density less than 20 X 10(6)/mL and/or less than 40% motile sperm and/or decreased sperm motility). A decreased number of motile sperm as well as a poor grade of motility appeared in the majority of semen specimens from both patient groups. However, 14 patients had semen that met our criteria for fertility with sperm density greater than or equal 20 X 10(6)/mL, greater than or equal 40% motile sperm, and motility grade greater than 2. Semen quality appeared to be better in patients referred immediately after diagnosis than in patients in whom there was a delay between diagnosis and referral for semen cryopreservation. Twelve patients with semen meeting our criteria for possible fertility and 42 patients failing our criteria elected to cryopreserve semen. A median of three collections per patient were stored. To date, seven patients have withdrawn semen for artificial insemination by husband attempts, and two of these attempts have resulted in pregnancies. Both attempts involved patients with semen that meet our criteria for potential fertility. In the minority of young men with lymphoma or testicular carcinoma who have good-quality semen, semen cryopreservation can preserve reproductive potential after therapy that might otherwise cause sterility.
Advanced reconstructive technologies for periodontal tissue repair
Authors: Christoph A. Ramseier, Giulio Rasperini, Salvatore Batia, William V. Giannobile
Journal: Periodontology 2000 (2012)

Reconstructive therapies to promote the regeneration of lost periodontal support have been investigated through both preclinical and clinical studies. Advanced regenerative technologies using new barrier-membrane techniques, cell-growth-stimulating proteins or gene-delivery applications have entered the clinical arena. Wound-healing approaches using growth factors to target the restoration of tooth-supporting bone, periodontal ligament and cementum are shown to significantly advance the field of periodontal-regenerative medicine. Topical delivery of growth factors, such as platelet-derived growth factor, fibroblast growth factor or bone morphogenetic proteins, to periodontal wounds has demonstrated promising results. Future directions in the delivery of growth factors or other signaling models involve the development of innovative scaffolding matrices, cell therapy and gene transfer, and these issues are discussed in this paper.
Negative cutaneous effects of medicinal plants in Senegal
Authors: S.O. Niang, Y. Tine, B.A. Diatta, M. Diallo, M. Fall, N.B. Seck, A. Kane
Journal: British Journal of Dermatology (2015)

Use of medicinal plants is common and widespread throughout Africa, including in Senegal. Because efficacy has been demonstrated, public policies have been instituted that have allowed plant-based therapies to have an important role in general primary care. However, little is known about the cutaneous safety of many plant-based therapies. In this 6-month prospective study all cases of dermatitis induced or aggravated by exclusive use of medicinal plants were evaluated via skin allergy testing. The results were classified and compared with the available literature. Forty-three cases of plant-therapy-associated cutaneous reactions were identified, including worsening of existing conditions (56%), recurrence of a previously resolved condition (16%) and new dermatitis arising spontaneously (28%). In the cases where the condition was new, generalized exfoliative dermatitis occurred in 42% of cases with an average time of onset of 9 days. Specific plants were identified in 65% of cases and included 18 varieties. The frequency and severity of plant-induced cutaneous reactions should be the basis for the creation of a phytovigilance programme and re-evaluation of how traditional medicine is used in the general population. When irritation occurs, identification of the responsible plant and allergy testing should be the first steps towards relieving symptoms.
Peripheral Blood Progenitor Cell Mobilization Using Stem Cell Factor in Combination With Filgrastim in Breast Cancer Patients
Authors: J.A. Glaspy, E.J. Shpall, C.F. LeMaistre, R.A. Briddell, D.M. Menchaca, S.A. Turner, M. Lill, L. Chap, R. Jones, M.D. Wiers, W.P. Sheridan, I.K. McNiece
Journal: Blood (1997)
Mortality Risk of Untreated Myosin-Binding Protein C–Related Hypertrophic Cardiomyopathy
Authors: Eline A. Nannenberg, Michelle Michels, Imke Christiaans, Danielle Majoor-Krakauer, Yvonne M. Hoedemaekers, J. Peter van Tintelen, M. Paola Lombardi, Folkert J. ten Cate, Arend F.L. Schinkel, Jan G.P. Tijssen, Irene M. van Langen, Arthur A.M. Wilde, Eric J.G. Sijbrands
Journal: Journal of the American College of Cardiology (2011)
LSC 2012 abstract - Mitochondrial metabolism controls lung fibroblast activation in vitro and in vivo
Authors: J. Schwarz, O. Eickelberg
Journal: European Respiratory Journal (2012)

Background: Fibroblasts exhibit an extraordinary capacity to undergo fibroblast-myofibroblast activation in association with diseases such as pulmonary fibrosis. Little is known regarding the role of mitochondrial function in fibroblast biology in general and phenotypic switching in fibrosis in particular.  Aims and objectives: To demonstrate the interplay of mitochondrial metabolism with fibroblast-myofibroblast activation.  Methods and Results: We demonstrate that stimulation of primary lung fibroblasts with the profibrotic cytokine TGFβ1 results in an enhanced mitochondrial membrane potential (ΔΨ m ). Moreover, proliferation, ECM deposition, and motility of these cells are increased compared to fibroblasts with lowΔΨ m . Interestingly, TGFβ1-stimulated cells displayed increased expression of profibrotic markers (αSMA, FN1 and Col1), demonstrating fibroblast-myofibroblast activation. To further corroborate these findings, we sorted primary lung fibroblasts for high and low resting ΔΨ m  (ΔΨ m H/L). While ΔΨ m H fibroblasts are morphologically indistinguishable, they demonstrate increased myofibroblast activation compared with ΔΨ m L fibroblasts. Finally, total cell homogenates derived from fibrotic, bleomycin-treated mice demonstrated increased ΔΨ m  compared with cell homogenates from saline-treated mice.  Conclusion: Our data suggest that mitochondrial metabolism plays an important role in the phenotypic activation of lung fibroblasts, both in TGFβ1 stimulated cells in vitro and bleomycin-induced fibrosis in vivo.
Abstract 1777: Bnip3 Induces a Global Increase in Histone Acetyltransferase Affecting Contractile Proteins and Promoting Contractile Dysfunction and Ventricular Dilation
Authors: John W Thompson, Regina M Graham, Jianqin Wei, Weiwen Wang, M. Grazia Spiga, Nanette H Bishopric, Keith A Webster
Journal: Circulation (2008)
Organ preservation for clinical T2N0 distal rectal cancer using neoadjuvant chemoradiotherapy and local excision (ACOSOG Z6041): results of an open-label, single-arm, multi-institutional, phase 2 trial
Authors: Julio Garcia-Aguilar, Lindsay A Renfro, Oliver S Chow, Qian Shi, Xiomara W Carrero, Patricio B Lynn, Charles R Thomas, Emily Chan, Peter A Cataldo, Jorge E Marcet, David S Medich, Craig S Johnson, Samuel C Oommen, Bruce G Wolff, Alessio Pigazzi, Shane M McNevin, Roger K Pons, Ronald Bleday
Journal: The Lancet Oncology (2015)
The impact of comorbidities related to BMI in COPD patients
Authors: Carlos Cabrera Lopez, Jorge Zagaceta, Claudia Cote, Miguel Divo, Juan Pablo De Torres, José María Marín, Ciro Casanova, Victor Pinto-Plata, Javier Zulueta, Bartolomé Celli, Santiago Carrizo
Journal: European Respiratory Journal (2011)

Introduction:  In COPD patients a higher BMI is associated with better survival (the obesity paradox). The mechanism of this paradox is not well understood. We explored whether different co-morbidities related to survival in patients with different BMI.   Methods:  We followed 1664 COPD patients of the BODE cohort. A total of 80 comorbidities were systematically recorded. Comorbidities prevalence and association with mortality was explored using Cox proportional hazard stratified by BMI in four groups (≤ 21, 22-29, 30-35, ≥ 36 kg/m 2 ).   Results:  COPD patients with BMI ≥ 36 had significantly more comorbidities than the other groups but they had lower mortality, better FEV1 and lower BODE.  No specific co-morbidities had an independent association with mortality in this group whereas they did in the other subsets. Patients with a BMI between 22 and 35 had the most number of comorbidities associated with death.   Conclusion:  In COPD, obese patients (BMI>36) have a better survival than non-obese patients, in spite of having more co-morbidities. In these obese patients there was no co-morbidity that was significantly and independently associated with mortality.
Oncolytic Potentials of Nonhuman Viruses for Human Cancer. II. Effects of Five Viruses on Heterotransplantable Human Tumors&lt;xref ref-type="fn" rid="FN2"&gt;2&lt;/xref&gt;
Authors: David S. Yohn, William Mcd. Hammon, Robert W. Atchison, Bruce C. Casto
Journal: JNCI Journal of the National Cancer Institute (1968)

Five viruses noninfectious for humans, namely infectious bovine rhinotracheitis (IBR), equine rhinopnenumonitis (ERP), simianadenovirus 15 (SV15), and bovine enteroviruses 1 (BE-1 ) and 180 (BE-180), were studied as potential oncolytic agents for human tumors by determination of their replicative capacity in, and inhibitory (oncolytic) effect on, at least 1 of 5 different human tumors heterotransplanted into Syrian hamster cheek pouches. Viruses IBR and ERP replicated in, and appeared to be oncolytic in, at least 1 tumor system each. SV15 appeared to replicate in H.Ep.#2 tumor but was not oncolytic. BE-1 and BE-180 did not replicate in the 3 tumors tested. The oncolytic properties of ERP in KB tumor and of IBR in HeLa tumor were found before passage of the virus in these tumors. Both herpesviruses had been adapted previously to the corresponding cell line from which the tumors had been developed. It was concluded that, though these results suggest an oncolytic potential for ERP and IBR, the final evaluation must be the result of clinical trials. These two viruses have the advantage that they do not appear to induce disease in humans.
Resection of primary tumor at diagnosis in stage IV-S neuroblastoma: does it affect the clinical course?
Authors: M Guglielmi, B De Bernardi, A Rizzo, S Federici, C Boglino, F Siracusa, A Leggio, F Cozzi, G Cecchetto, L Musi, T Bardini, A M Fagnani, G C Bartoli, A Pampaloni, D Rogers, M Conte, C Milanaccio, P Bruzzi
Journal: Journal of Clinical Oncology (1996)

PURPOSE To determine whether resection of primary tumor has a favorable influence on outcome of infants (age 0 to 11 months) with stage IV-S neuroblastoma. PATIENTS AND METHODS Between March 1976 and December 1993, 97 infants with previously untreated neuroblastoma diagnosed in 21 Italian institutions were classified as having stage IV-S disease. Seventy percent were younger than 4 months. Adrenal was the primary tumor site in 64 of 85 patients with a recognizable primary tumor. Liver was the organ most often infiltrated by the tumor (82 patients), followed by bone marrow and skin. RESULTS The overall survival (OS) rate at 5 years in 80% and event-free survival (EFS) rate 68%. In 24 infants, the effect of resection of primary tumor could not be evaluated because of rapidly fatal disease progression (n = 8), absence of a primary tumor (n = 12), or partial resection (n = 4). Of 73 assessable patients, 26 underwent primary tumor resection at diagnosis: one died of surgical complications, one relapsed locally and died, and two others relapsed (one of these two locally) and survived, for a 5-year OS rate of 92% and EFS rate of 84%. Of the remaining 47 patients who did not undergo primary tumor resection at diagnosis 11 suffered unfavorable events, of whom five died, for an OS rate of 89% and EFS rate of 75% (no significant difference from previous group). Disease recurred at the primary tumor site in only one five who died, and in only one of six survivors of progression or relapse; in these patients, the primary tumor, located in the mediastinum, was successfully resected. CONCLUSION Infants who underwent resection of the primary tumor at diagnosis had no better outcome than those in whom the decision was made not to operate.
Recent trial shows that solanezumab has disease modifying effects
Authors: Eric Karran
Journal: BMJ (2015)

McCartney raises important points about the media reporting of solanezumab but does not fully explore the data’s real importance.1

Current drugs for Alzheimer’s disease treat the symptoms only.2 Disease modifying drugs could reduce the numbers of people living with severe stage Alzheimer’s.3

The extension study (EXPEDITION-EXT) was designed to …
An audit on emergency oxygen administration and safety issues
Authors: Rajesh Kumar Yadavilli, Nadeem Anwar, Brian Bradley
Journal: European Respiratory Journal (2011)

Background:  British Thoracic Society (BTS) guidelines on Emergency Oxygen (O2) in 2008 highlighted the importance of safe prescription and administration of O2. We audited our practice focussing on the documentation, prescription and complications in a busy district general hospital in UK.   Methods:  Audit was performed on patients admitted to the medical admission unit over a period of 3 months between Jan 2010 to Mar 2010. Patients who had O2 were randomly selected and monitored from admission to discharge.   Results:  56 patients in total were studied.  46% had assessment for the risk of Co2 retention before O2 started.  Only 34% had documentation of target O2 saturations.  Documentation of Device in 66%, Flow in 71% and Fio2 in 32% of cases.  96% of drug charts had no prescription of O2.  There is no documentation how long O2 should be given in all the cases.  20 (36%) patients had inappropriate administration of O2; No need for O2-10, More O2 than needed-9 and Less O2 than needed-1.  3 patients developed Type 2 respiratory failure and needed Non-invasive ventilation.  There were no mortalities.   Conclusions:  We identified safety issues whilst administering Emergency O2 and need to improve in our documentation, prescription on drug charts and administration.  Patients at risk of Co2 retention would have arterial blood samples after starting O2.  Drug charts were modified adding oxygen in 2 areas: Regular and PRN sections and also include device, flow, Fio2, target saturations and how long to give O2.  Flow charts on how to administer and adjust O2 were placed in all the wards including medical admission units.  Repeated mandatory educational training on O2 administration to all medical, nursing and allied health care professionals were started.
Biofilm formation and prevalence of lukF-pv, seb, sec and tst genes among hospital- and community-acquired isolates of some international methicillin-resistant Staphylococcus aureus lineages
Authors: R.R. Souza, L.R. Coelho, A.M.N. Botelho, A. Ribeiro, P.N. Rito, V.V. Vieira, L.A. Teixeira, B.T. Ferreira-Carvalho, A.M.S. Figueiredo
Journal: Clinical Microbiology and Infection (2009)
Comparison of exercise capacity in adult asthmatic incremental shuttle walk test and incrementalcardiopulmonary exercise test
Authors: Ivana G. Labadessa, Audrey Borghi e Silva, Adriana S.G. Araujo, Marcos M. de Araujo, Cristiane L. Garbim, Valéria A. Pires Di Lorenzo
Journal: European Respiratory Journal (2014)

Background:  the maximum tests are considered standard for assessment of exercise capacity, however; clinical trials as the Incremental Shuttle Walk Test (ISWT) are valid, reproducible and safe. Although, ISWT has been used to assess exercise capacity of patients with Chronic Obstructive Pulmonary Disease (COPD), there are few studies on metabolic and cardiovascular responses during ISWT in adult asthmatics.  Aims:  To compare the oxygen consumption (VO2 ml/min) and heart rate (HR%) obtained at peak ISWT and at incremental cardiopulmonary exercise test (ICPET) of asthmatics.  Methods  :  16 adult asthmatics (28 ± 8 years; FEV1 96±20% predictiveand FEV1/FVC 77±17% were evaluated. In two non-consecutive days, it was accomplished: ISWT and ICEPT on a treadmill (modified Balke) with VO2 uptake (Oxycon) and HR during the tests.  Results:  The distance traveled in ISWT was 538±86 meters, reaching 71±8% pred. The peak speed achieved in ICPET was 6 ± 0.6 km/h, the slope of 12 ± 2% and of 10 ± 1 minutes test. The values found in peak ISWT and ICPET, respectively were: VO2= 1955±499 vs. 1990±578 ml/min and VO2 provided corresponding to 103±17 vs. 104±21% of VO2 expected, no significant difference was found, however; in the case of percentage of predicted maximum heart rate (HRmax) = 85±10 vs. 91±9%, was found in ISWT lower value when compared to ICPET (p=0.008).  Conclusion:  We conclude the metabolic response in asthmatic patients was similar between the ISWT and ICPET, with lower cardiovascular demand at peak ISWT compared to ICPET.   Financial support: no2011/23771-7   Sao Paulo Research Foundation (FAPESP) .
Abstract 4087: Identification of microRNAs involved in shaping immune surveillance and growth properties of tumors
Authors: Barbara Seliger, Simon Jasinski-Bergner, Juergen Bukur, Kristin Schulz, Franziska Stehle
Journal: Cancer Research (2014)

Abstract Ligands of the natural killer (NK) cells and CD8+ cytotoxic T lymphocyte (CTL) receptors, such as the inhibitory classical HLA-G antigen, are often deregulated upon viral infection and neoplastic transformation thereby allowing virus-infected or malignant-transformed cells to escape NK and T cell-mediated immune surveillance. The underlying molecular mechanisms controlling the aberrant HLA-G expression have been recently identified suggesting that cellular microRNAs (miRs) target the 3′UTR of HLA-G mRNA thereby shaping the anti-tumoral immune response. Functional analysis of these miRs demonstrated an inverse correlation of HLA-G and miR expression, which was directly associated with tumor grading, staging, disease progression and survival of renal cell carcinoma patients. Furthermore, these miRs enable tumors to evade NK and T cell cytotoxicity. Using 2DE-based proteome analysis in combination with MALDI-TOF mass spectrometry of HLA-G-specific miR transfectants and control cells lead to the identification of novel targets of these miRs including the 14-3-3-β protein (YWHAB). The miR-regulated YWHAB expression not only alters tumor cell proliferation, but also the sensitivity to apoptosis. Loss of HLA-G-specific miRs enhanced YWHAB expression, which is accompanied by an inhibition of pro-apoptotic gene expression leading to apoptosis resistance, enhanced proliferation, migration and tumor progression. Furthermore, YWHAB expression and lack of HLA-G-specific miR expression directly correlate with a worse clinical outcome of HLA-G+ tumors linking for the first time tumor immune escape mechanisms with the malignant phenotype. Thus, the HLA-G-regulating miRs not only affect immune surveillance, but also enhance tumorigenicity. Citation Format: Barbara Seliger, Simon Jasinski-Bergner, Juergen Bukur, Kristin Schulz, Franziska Stehle. Identification of microRNAs involved in shaping immune surveillance and growth properties of tumors. [abstract]. In: Proceedings of the 105th Annual Meeting of the American Association for Cancer Research; 2014 Apr 5-9; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2014;74(19 Suppl):Abstract nr 4087. doi:10.1158/1538-7445.AM2014-4087
Late-breaking abstract: Factors associated with medication adherence in patients with COPD
Authors: Ilkay Koca Kalkan, A. Fusun Kalpaklioglu
Journal: European Respiratory Journal (2011)

Background:  Only about 50% of patients with COPD,4th leading cause of death, adhere to prescribed regimen.Non-adherence is one of the most important obstacles in achieving optimized clinical-outcome.The purpose of this study is to identify the clinical predictors of medication adherence.   Method:  51 patients with prescribed regular medication due to COPD, were included in the study. Sociodemographic (age, sex, educational level, BMI, comorbidity, number of additional drugs); COPD-related (smoking habits, duration of disease,MRC-dyspnea-score, treatment, exacerbations) and spirometry variables were recorded. Personality traits (Eysenck Personality Questionnaire), self report of medication adherence (MARS) and health related quality of life (SF-36) were evaluated.   Results:  The mean-age was 63±9.2 years, 48 (94%) were male, 68.6% had low-educational level (≤8 years), mean-FEV1 was 40.4±20.9%, 58% had MRC-score of ≤3, exacerbations-per-year was 2.2±1.9. 22 of the patients had comorbid-diseases with mean number of 3.7±2.4 additional drugs and weren9t correlated with MARS. Mean MARS was 20.6±4.1 and 33.3% were nonadherent. MARS was correlated neither with personality traits nor SF-36. MARS was significantly higher in patients; whom reported themselves as regular-medication-user and benefited from therapy (p   Conclusions:  We found that; neither the sociodemographic variables, personality traits nor the disease severity; but the routinization of recommended treatment and faith in the treatment are critical for optimal medication adherence in patients with COPD
Frequent occurrence of T cell–mediated late reactions revealed by atopy patch testing with hypoallergenic rBet v 1 fragments
Authors: Raffaela Campana, Katharina Moritz, Katharina Marth, Angela Neubauer, Hans Huber, Rainer Henning, Katharina Blatt, Gregor Hoermann, Tess M. Brodie, Alexandra Kaider, Peter Valent, Federica Sallusto, Stefan Wöhrl, Rudolf Valenta
Journal: Journal of Allergy and Clinical Immunology (2015)

Late allergic reactions are common in the course of allergen-specific immunotherapy and even occur with allergy vaccines with reduced IgE reactivity.We sought to study atopy patch test (APT) reactions and T-cell responses to the recombinant birch pollen allergen Bet v 1 and recombinant hypoallergenic T-cell epitope-containing Bet v 1 fragments in patients with birch pollen allergy with and without atopic dermatitis (AD).A clinical study was conducted in 15 patients with birch pollen allergy with AD (group 1), 5 patients with birch pollen allergy without AD (group 2), 5 allergic patients without birch pollen allergy (group 3), and 5 nonallergic subjects (group 4) by performing skin prick tests and APTs with rBet v 1 and hypoallergenic rBet v 1 fragments. T-cell, cutaneous lymphocyte antigen (CLA)(+) and CCR4(+) T-cell and cytokine responses were studied by thymidine uptake, carboxyfluorescein diacetate succinimidyl ester staining, and Luminex technology, respectively.rBet v 1 and hypoallergenic rBet v 1 fragments induced APT reactions in not only most of the patients with birch pollen allergy with AD (11/15) but also in most of those without AD (4/5). Patients with birch pollen allergy with AD had higher Bet v 1-specific proliferation of CLA(+) and CCR4(+) T cells compared with patients with birch pollen allergy without AD. There were no differences in Bet v 1-specific CLA(+) and CCR4(+) proliferation and cytokine secretion in patients with and without APT reactions.Hypoallergenic rBet v 1 fragments induce T cell-dependent late reactions not only in patients with birch pollen allergy with AD but also in those without AD, which can be determined based on APT results but not based on in vitro parameters.