tbuckley/cabot-search huggingface dataset:
SAT0580-HPR Women and Men with Polymyositis and Dermatomyositis have Reduced Grip Force and Health Related Quality of Life at Time of Diagnosis: a Registry Study
Authors: M. Regardt, M.-L. Schult, H. Alexanderson, L. Alemo Munters, M. Dastmalchi, L. Dani, M. Lidén, K. Lundsten, I. E. Lundberg, E. Welin Henriksson
Journal: Annals of the Rheumatic Diseases (2013)

<h3>Background</h3> Polymyositis (PM) and dermatomyositis (DM) have proximal muscle weakness. Reduced grip force has previously been shown in a cross sectional study. <h3>Objectives</h3> To (I) compare women and men with PM/DM to reference values from the literature regarding grip force and Health Related Quality of Life (HRQoL) from time of diagnosis to 6 years of disease duration, (II) investigate how grip force changes over time and (III) investigate correlations between grip force and HRQoL. <h3>Methods</h3> 89 patients with PM/DM (women n=52, men n=37) from the Swedish Myositis Network registry were included in this multicentre prospective study. Grippit was used to assess grip force and Short Form-36 (SF-36) for HRQoL. <h3>Results</h3> (I) Women and men had reduced grip force compared to reference values at time of diagnosis (p&lt;0.001) and up to 6 (p≤0.018) and 3 (p≤0.044) years disease duration respectively. Women and men rated lower HRQoL than reference values at time of diagnosis (p≤0.018). (II) Over time there was an increase in grip force between time of diagnosis and to follow up at 1 year (p&lt;0.001) and two years (p≤0.035). (III) There were moderate to high correlations between grip force and HRQoL <h3>Conclusions</h3> Conclusions: Women and men with PM/DM had reduced grip force compared to reference values at time of diagnosis. The grip force improved after time of diagnosis and men reached normal levels at four years whereas women had low grip force even after 6 years. The correlation with HRQoL may indicate a clinical significance of the low grip force in these patients. <h3>Disclosure of Interest</h3> None Declared
Obesity, inflammation, and liver cancer
Authors: Beicheng Sun, Michael Karin
Journal: Journal of Hepatology (2011)

Obesity has become a universal and major public health problem with increasing prevalence in both adults and children in the 21st century, even in developing countries. Extensive epidemiological studies reveal a strong link between obesity and development and progression of various types of cancers. The connection between obesity and liver cancer is particularly strong and obesity often results in liver diseases such as non-alcoholic fatty liver disease (NAFLD) and the more severe non-alcoholic steatohepatitis (NASH). NASH is characterized by fatty liver inflammation and is believed to cause fibrosis and cirrhosis. The latter is a known liver cancer risk factor. In fact due to its much higher prevalence obesity may be a more substantial contributor to overall hepatocellular carcinoma burden than infection with hepatitis viruses. Here we review and discuss recent advances in elucidation of cellular and molecular alterations and signaling pathways associated with obesity and liver inflammation and their contribution to hepatocarcinogenesis. Obesity has become a universal and major public health problem with increasing prevalence in both adults and children in the 21st century, even in developing countries. Extensive epidemiological studies reveal a strong link between obesity and development and progression of various types of cancers. The connection between obesity and liver cancer is particularly strong and obesity often results in liver diseases such as non-alcoholic fatty liver disease (NAFLD) and the more severe non-alcoholic steatohepatitis (NASH). NASH is characterized by fatty liver inflammation and is believed to cause fibrosis and cirrhosis. The latter is a known liver cancer risk factor. In fact due to its much higher prevalence obesity may be a more substantial contributor to overall hepatocellular carcinoma burden than infection with hepatitis viruses. Here we review and discuss recent advances in elucidation of cellular and molecular alterations and signaling pathways associated with obesity and liver inflammation and their contribution to hepatocarcinogenesis.
The Power of Clan: The Influence of Human Relationships on Heart Disease
Authors: Robert S. Eliot
Journal: JAMA (1994)

At a time when our consciousness has been raised by the strength of religious cults and the weakening and fragmentation of the family and community, especially in inner cities, this unique monograph details an exhaustive 50-year study of community and family connectedness correlating with a very low incidence of coronary heart disease in Roseto, Pennsylvania. Roseto is a community of approximately 2700 and was originally nearly 100% immigrants from a southern Italian community of peasants that bore the same name. The authors propose to explain the very low (less than one half) incidence of coronary heart disease up to 1965 in Roseto compared with the four immediately surrounding (within 10 miles) communities as the result of remarkable community and family cohesiveness and<i>in the absence of any differentials in the accepted coronary heart disease risk factors</i>. Meticulous attention was paid to tracking and detailing the history of sociobiologic events, beginning
Development of a Monoclonal Anti-Immunoglobulin E Antibody (Omalizumab) for the Treatment of Allergic Respiratory Disorders
Authors: EDWARD S. SCHULMAN
Journal: American Journal of Respiratory and Critical Care Medicine (2001)

Section:ChooseTop of pageAbstract <<STRATEGY FOR INHIBITING I...EFFECTS OF OMALIZUMAB ON ...INITIAL CLINICAL EXPERIEN...EFFECT OF OMALIZUMAB ON A...EFFECT OF OMALIZUMAB ON A...CONCLUSIONSReferencesCITING ARTICLES
Overview of occupational exposure to electric and magnetic fields and cancer: advancements in exposure assessment.
Authors: D A Savitz
Journal: Environmental Health Perspectives (1995)

For over ten years, there has been concern with the potential for increased risk of cancer among "electrical workers." In contrast to studies of residential exposure to magnetic fields, occupational studies include electric and magnetic field exposures and have much greater variability in field intensity, frequency, and temporal patterns. Studies of leukemia in electrical workers show a moderate consistency, with elevated risk ratios of 1.2 to 2.0 commonly observed. Brain tumors are similarly elevated with some consistency, and three recent studies have suggested increased risk of male breast cancer. Retrospective exposure assessment methods were advanced in recent studies of diverse occupations in a study in central Sweden, which yielded evidence of increased risk of chronic lymphocytic leukemia among men in more highly exposed occupations. A study of telephone workers in New York State incorporated measurements and found some indication of increased leukemia risk only when exposures were based on historical technology. Utility workers in southern California were studied and found not to have increased risks of leukemia and brain cancer based on exposures estimated with measurements. An ongoing study of electric utility workers at five companies in the United States incorporates an extensive measurement protocol. Randomly selected workers within occupational categories wore a time-integrating magnetic-field meter to provide estimates of exposure for the occupational category. We were able to estimate and partition the variance into between-day (the largest contributor), within occupational categories, and between occupational categories. Principal research needs concern optimal levels of worker aggregation for exposure assignment, historical extrapolation, study of diverse work environments, and integration of residential and occupational exposure in the same study.
Insights into the Physiology of Childbirth Using Transcriptomics
Authors: Roberto Romero, Adi L Tarca, Gerard Tromp
Journal: PLoS Medicine (2006)

Adjusted P.Val NDN 36073_at -0.90 3.09 -6.15 9.33E-03 SC4MOL 33369_at -0.67 1.78 -6.06 9.33E-03 NPEPPS 39431_at -0.69 2.12 -6.00 9.33E-03 PTGDS 38406_f_at -1.72 8.03 -5.33 3.31E-02 CLOCK 36080_at -0.96 3.86 -5.27 3.31E-02 ECH1 32756_at -0.94 4.97 -5.25 3.31E-02 HMGN3 37348_s_at -1.09 3.24 -5.11 3.31E-02 RAMP2 38177_at -1.14 3.84 -5.07 3.31E-02 CD24 266_s_at -1.68 2.51 -5.05 3.31E-02 ALDH9A1 33899_at -1.01 3.30 -5.03 3.31E-02 ADD3 33102_at -1.74 3.46 -4.98 3.31E-02 TCF12 33348_at -0.66 2.51 -4.97 3.31E-02 DAAM1 33753_at -1.38 3.09 -4.97 3.31E-02 DKFZP586A0522 38717_at -1.26 3.33 -4.86 3.56E-02 CYP3A5 37124_i_at 0.59 2.37 4.86 3.56E-02 PTGDS 216_at -1.53 8.09 -4.84 3.56E-02 PCNA 1884_s_at -0.56 2.23 -4.82 3.56E-02 NUMA1 33822_at -0.55 5.20 -4.82 3.56E-02 MGC5508 39693_at -1.08 4.97 -4.76 3.70E-02 EIF3S3 35327_at -0.78 3.69 -4.76 3.70E-02 PTN 234_s_at -1.05 2.50 -4.73 3.70E-02 CLNS1A 38732_at -0.58 2.83 -4.72 3.70E-02 SCNN1A 35207_at -0.94 3.25 -4.71 3.70E-02 PPP1R3C 39366_at -2.27 2.82 -4.70 3.70E-02 IGF1 1501_at -1.48 4.71 -4.67 3.70E-02 ALPL 36623_at 0.85 4.05 4.66 3.70E-02 HNRPA0 37334_at -0.43 1.96 -4.65 3.70E-02 UBE2E3 34850_at -0.56 2.75 -4.61 3.98E-02 PTN 34820_at -1.29 3.75 -4.60 3.98E-02 HTR1E 33607_at 0.57 2.58 4.58 3.98E-02 PTPLB 35342_at -0.87 2.42 -4.573.98E-02 DUSP7 39932_at -0.56 2.
Resident Workload—Let's Treat the Disease, Not Just the Symptom
Authors: Lara Goitein, Kenneth M. Ludmerer
Journal: JAMA Internal Medicine (2013)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Internal Medicine HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Internal Medicine journal
Lymphoma as a Second Malignancy in a Patient With Neuroendocrine Tumor
Authors: Sachin Jain, Punit Sharma, Varun Singh Dhull, Chandrasekhar Bal, Rakesh Kumar
Journal: Clinical Nuclear Medicine (2013)

Neuroendocrine tumors (NETs) are rare tumors which express somatostatin receptors (SSTRs). We here present a case of a 50-year-old female patient with metastatic bronchial carcinoid. She underwent 68Ga-DOTANOC PET/CT and 18F-FDG PET/CT which suggested a diagnosis of poorly differentiated NET. Biopsy of the lesion, however, revealed a second malignancy in the form of diffuse large B-cell lymphoma. Thus, very rarely, other primary tumors can mimic NETs on dual-tracer PET/CT, and biopsy is advised in doubtful cases.
CHANCRE OF THE EYELID
Authors: PHILIP F. SHAFFNER
Journal: JAMA (1918)

A widow, aged 58, Irish, referred by Dr. Leigh E. Schwarz, consulted me for a lesion of four weeks' duration, situated on the left lower eyelid. In addition to the ulceration on the lid, a large, painless, hard, freely movable gland could be palpated under the angle of the left jaw. A clinical diagnosis of primary syphilis, which was confirmed by demonstration of the Spirochaeta pallida with the dark field illuminator, was made.  After prolonged questioning of the patient as to the possible mode of infection, it was learned that a member of her family had had a sore throat for some months. Examination of that person revealed a typical syphilitic angina, mucous plaques on the cheek, a fading roseola and a generalized lymphadenopathy. This patient finally volunteered the information that she had employed the tongue to remove a foreign body from the victim's eye. This was unquestionably the mode
Antibodies to polymerized human serum albumin in acute and chronic liver disease
Authors: William M. Lee, Lizabeth McLeod, Kylie Martin, David L. Emerson, Robert M. Galbraith
Journal: Hepatology (1987)

Since antibodies to polyalbumin have been noted to occur in patients with hepatitis or cirrhosis, we investigated sera from 219 patients with a variety of acute and chronic liver diseases with and without HBsAg using an ELISA. The prevalence of circulating polyalbumin antibodies was shown to be significantly increased over that of healthy controls (6.7%) in patients with autoimmune chronic active hepatitis (67%), acute viral hepatitis (41%) and fulminant hepatic necrosis (38%), but such antibodies were absent in chronic hepatitis B patients and other liver diseases. Serial studies in acute hepatitis showed evidence of antibodies early in the course of illness with disappearance prior to full recovery. In acute hepatitis B, the presence of polyalbumin antibodies was significantly associated with female sex (p less than 0.01), 3-fold higher transaminase levels and shorter duration of clinical illness (less than 4 weeks in all cases). Polyalbumin antibodies appear to be associated with diseases characterized by active hepatocyte necrosis. Since they are evident early in acute hepatitis B when complexes of polyalbumin and virus are likely, these antibodies may play an adjunctive role to other hepatitis B-related antibodies in the clearance of hepatitis B virus infection.
The NIH Consensus-Development Program and the Assessment of Health-Care Technologies
Authors: Seymour Perry, John T. Kalberer
Journal: New England Journal of Medicine (1980)

The need and the demand for assessment of health-care technologies are growing rapidly. Biomedical research and development, especially since World War II, have dramatically increased the ability to prevent, diagnose, and manage a wide variety of diseases. These same advances have brought with them serious scientific, medical, economic, social, legal, and ethical questions. The public and its representatives, as well as the biomedical community, have thus called increasingly for comprehensive, balanced evaluations of recommendations regarding the use of health-care technologies.The 1970's witnessed a greater emphasis on extension and formalization of the role of the National Institutes of Health (NIH), . . .
Hyperbaric Oxygen Therapy in Mice Injected With Tetanus Toxin
Authors: Norman A. Christensen
Journal: JAMA (1967)

The any highly effective, predictable form of treatment for patients victimized by tetanus has challenged the medical profession for centuries. Progress in therapy has been painfully slow, so that morbidity and mortality have not been altered appreciably in the past several decades. Thus, tetanus retains its unsavory position as one of man's most dread disease. Bytchenko,<sup>1</sup>in a recent report to the World Health Organization, stated that during the ten-year period of 1951 through 1960 there were more than 1 million victims of this disease; more importantly, approximately 500,000 of them died. Renewed interest in the therapeutic use of hyperbaric oxygen in various diseases in recent years has led to trials of this treatment in patients afflicted with anaerobic infections. Boerema (written communication, Sept 30, 1964), though encouraged by observations on its use in 50 patients with gas gangrene, did not see any startling benefits in 13 patients with
Lymphoproliferative cancer and other malignancy in patients with rheumatoid arthritis treated with azathioprine: a 20 year follow up study.
Authors: A J Silman, J Petrie, B Hazleman, S J Evans
Journal: Annals of the Rheumatic Diseases (1988)

Two hundred and two patients with rheumatoid arthritis (RA) starting treatment with large doses of azathioprine (median 300 mg/day) between 1964 and 1974 were followed up until March 1984. All but one patient (99.5%) were traced from either hospital or general practice records; and death certificates, where relevant, were obtained. A comparison group of 202 patients with RA not treated with azathioprine was selected from the diagnostic index of another rheumatology unit and followed up in 1985 to assess their status retrospectively at March 1984. Each patient treated with azathioprine was matched for year of birth, year of diagnosis, sex, and serostatus with a control patient from the latter group. Four lymphoproliferative cancers occurred in the azathioprine treated group compared with two in the control group. Further analysis of these findings suggested an increased risk of lymphoma of one case per 1000 patient years of azathioprine treatment. The lymphoma rates were then compared with those expected based on the incidence in the general population. This comparison suggested a fivefold increase in the RA control group and a 10-fold increase in the azathioprine treated group. There was also an excess of patients with non-lymphoproliferative cancers, including one with myeloma in the azathioprine group (29 v 19), the excess being greater in the group with the longest duration of treatment. This significantly increased risk did not, however, persist on matched analysis, was not related to maximum daily dose, and was not site specific. These results from a possibly unique series of patients treated with high dose azathioprine give some reassurance about the magnitude of the previously postulated carcinogenic risk of such treatment in RA.
Autoantibody Reactive with RNA Polymerase III in Systemic Sclerosis
Authors: Yutaka Okano
Journal: Annals of Internal Medicine (1993)

Objective: To determine the clinical significance of anti-RNA polymerase III antibody in systemic sclerosis (SSc). Design: A point prevalence study of autoantibody to RNA polymerase III and longitudinal examination of its clinical significance in patients with SSc and in controls. Setting: University medical center rheumatology practice. Patients: Two hundred fifty-two consecutive new patients with SSc and 170 controls (150 patients with other connective tissue diseases and 20 normal volunteers). Measurements: The presence of anti-RNA polymerase III antibody was determined by immunoprecipitation, immunoblotting, and immunodepletion studies. Main Results: Serum specimens from 57 of the 252 patients with SSc (23%; 95% CI, 18% to 28%) reacted with RNA polymerase III, compared with none of the specimens from 170 controls (0%; 95% CI, 0% to 2%). In 40 of these 57 specimens, immunoprecipitation studies also showed the presence of RNA polymerase I or II, or both. Anti-RNA polymerase III antibody was detected in sera from 50 of the 111 patients (45%) who had SSc with diffuse cutaneous involvement (dcSSc), 7 of 114 patients (6%) who had SSc with limited cutaneous involvement, and none of 27 patients with an SSc overlap syndrome (P < 0.001). Among patients with dcSSc, anti-RNA polymerase III antibody was more common than antitopoisomerase I antibody (45% compared with 27%; P = 0.008). Patients with anti-RNA polymerase III antibody had a statistically significant higher mean maximum skin thickness score but statistically significant lower frequencies of telangiectasias, inflammatory myopathy, restrictive lung disease, and serious cardiac abnormalities than did patients with antitopoisomerase I antibody. Conclusion: Anti-RNA polymerase III antibody is a new marker autoantibody for many patients who have SSc with diffuse or extensive cutaneous involvement.
Peli1 promotes microglia-mediated CNS inflammation by regulating Traf3 degradation
Authors: Yichuan Xiao, Jin Jin, Mikyoung Chang, Jae-Hoon Chang, Hongbo Hu, Xiaofei Zhou, George C Brittain, Christine Stansberg, Øivind Torkildsen, Xiaodong Wang, Robert Brink, Xuhong Cheng, Shao-Cong Sun
Journal: Nature Medicine (2013)
Metrication on the Crawl
Authors: F.J. Ingelfinger
Journal: New England Journal of Medicine (1975)

Slowly but surely, grains, drachms, ounces and pounds, and inches and feet, have disappeared from the pages of the Journal, and metrication will probably supersede in spite of wiseacres who demand, "don't give them another 2.54 centimeters." In the 30's, reporting of serum chlorides changed from "milligrams percent" to milli-equivalents per liter. The concentration of acid in gastric contents is no longer recorded, for example, as 10 units per 100 cc, but as pH 2. "Cc" has been replaced by ml, and millimicrogram by nanogram. In July, 1971, temperatures recorded in the Journal changed from degrees Fahrenheit to Celsius. . . .
Monopolistic Control of Medical Literature.
Authors: Geo. M. Gould
Journal: JAMA (1897)

Philadelphia, Feb. 20,1897. <h3>To the Editor of the Medical Record:</h3> —In your editorial columns (issue of Feb. 13, 1897, pp. 234-5) you permit a letter to be published as your own ("Both editors and publishers") which is so diametrically opposite in view to that you personally gave myself (in company with Dr. Pyle) when calling upon you that I must beg for a word of explanation in reply. Where is now your "dead line" across which you repeatedly said your publishers could not go in control of your editorial utterance? Moreover, who are the "editors" of the<i>Medical Record</i>? Your announcement cites yourself as the single editor. If there are others they should certainly be named, as the profession should know its members who take this attitude to professional interests. And now, sir, of what use is it for you to allow such statements to appear in your columns as
ERCC1-Specific Immunostaining in Non–Small-Cell Lung Cancer
Authors: Ken A. Olaussen, Pierre Fouret, Guido Kroemer
Journal: New England Journal of Medicine (2007)

The Author Replies: I agree with Fine that "futility cases" -situations in which patients or family members demand treatments that seem unreasonable to the clinicians involved -are an important and difficult problem.I also agree that the Texas legislation has been effective in facilitating the resolution of these cases in a very efficient manner.We disagree, however, over the question of whether this approach can withstand ethical scrutiny and whether it is the best way of handling these challenging cases.Although it is true that the demands of some families are motivated by psychopathology or magical thinking, in some cases the dispute arises from a genuine disagreement about fundamental values.The problem with the Texas legislation is that it empowers the hospital ethics committee -mostly hospital employees -to adjudicate between the values of their fellow clinicians and