SYSTEMIC RETICULOENDOTHELIOSIS (LETTERER-SIWE DISEASE) IN THE ADULT MALE
Authors: ALTON M.  PAULL, ARTHUR M.  PHILLIPS
Journal: Annals of Internal Medicine (1954)

Case Reports1 August 1954SYSTEMIC RETICULOENDOTHELIOSIS (LETTERER-SIWE DISEASE) IN THE ADULT MALEALTON M. PAULL, M.D., ARTHUR M. PHILLIPS, M.D.ALTON M. PAULL, M.D.Search for more papers by this author, ARTHUR M. PHILLIPS, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-41-2-363 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptIt is now believed that the diverse manifestations of reticuloendotheliosis are merely different phases of one disease.1, 2, 3, 4The clinical picture produced depends on the rapidity of the pathologic process and the locations involved by the lesions. The more rapidly progressive and disseminated form described chiefly in infants and young children is characterized by generalized adenopathy, often hepatosplenomegaly, fever, purpura, anemia, cachexia and a fatal outcome.5Although rare, similar cases have been described in adults.6, 7The more chronic form of the disease usually evidences itself as either xanthoma disseminata of the skin, eosinophilic granuloma of bone, the...Bibliography1. Wallgren A: Systemic reticuloendothelial granuloma; nonlipoid reticuloendotheliosis and Schüller-Christian disease (relation to Letterer-Siwe's disease), Am. J. Dis. Child. 60: 471-500, 1940. CrossrefGoogle Scholar2. GrossJacox PHW: Eosinophilic granuloma and certain other reticuloendothelial hyperplasias of bone. A comparison of clinical, radiologic, and pathologic features, Am. J. M. Sc. 203: 673-687, 1942. CrossrefGoogle Scholar3. Malloy TB: Diseases of bone, New England J. Med. 227: 955-960, 1942. CrossrefGoogle Scholar4. McCullough NB: Eosinophilic granuloma with multiple osseous soft tissue lesions in an adult, Arch. Int. Med. 88: 243-251, 1951. CrossrefGoogle Scholar5. Freud P: Evaluation of systemic reticuloendotheliosis in childhood, J. Pediat. 38: 744-769, 1951. CrossrefMedlineGoogle Scholar6. ScottRobb-Smith RBAH: Histocytic medullary reticulosis, Lancet 2: 194-198 (July 22) 1939. CrossrefGoogle Scholar7. Asher R: Histiocytic medullary reticulosis: case without lymphadenopathy, Lancet 1: 650-651 (May 4) 1946. CrossrefMedlineGoogle Scholar8. Fisher RH: Multiple lesions of bone in Letterer-Siwe disease, J. Bone and Joint Surg. 35-A: 445-464, 1953. CrossrefGoogle Scholar9. Thannhauser SF: Lipoidosis—diseases of cellular lipid metabolism, 1950, Oxford University Press, New York. Google Scholar10. Unpublished data. Google Scholar11. BiermanLanhamDodKellyMillerShimkin HRJTKSKHERMB: The ameliorative effect of antibiotics on non-lipoid reticuloendotheliosis (Letterer Siwe disease) in identical twins, J. Pediat. 40: 269-284, 1952. CrossrefMedlineGoogle Scholar12. Aronson RP: Streptomycin in Letterer-Siwe's disease, Lancet 1: 889-890, 1951. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Providence, Rhode Island*Received for publication October 30, 1953.From the Medical Service, Veterans Administration Hospital, Providence, Rhode Island. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byLetterer-siwe disease in adultsSystemic giant-cell histiocytosis.Report of a case and a review of the adult form of letterer-siwe diseaseDie Letterer-Christiansche Krankheit (Histiocytosis X)Eine besondere morphologische Verlaufsform der prim�r chronischen Polyarthritis (p.c.P.)SpeicherkrankheitenDie paraproteinämischen HämoblastosenZur Klassifizierung atypischer paraproteinämischer HämoblastosenParaproteinämie bei Hand-Schüller-Christianscher ErkrankungDie Letterer-Christiansche ErkrankungCHRONIC, DISSEMINATED, NONLIPOID RETICULOENDOTHELIOSIS (HISTIOCYTOSIS X): TREATMENT WITH CORTICOTROPIN AND ANTIBIOTICS, WITH REPORT OF TWO CASES*PAUL H. MORTON, M.D., F.A.C.P.Monocytic leukemia 1 August 1954Volume 41, Issue 2Page: 363-371KeywordsBoneChildrenFeversGranulomasHepatosplenomegalyInfantsLesionsMedical servicesMetastasisSystemic diseases ePublished: 1 December 2008 Issue Published: 1 August 1954 PDF downloadLoading ...