Sarcoidosis and the Human T-cell Leukemia-Lymphoma Virus
Authors: Douglas W. Blayney, Prashant K. Rohatgi, William Hines, Marjorie Robert-Guroff, W. Carl Saxinger, William A. Blattner, Robert C. Gallo
Journal: Annals of Internal Medicine (1983)

Letters and Corrections1 September 1983Sarcoidosis and the Human T-cell Leukemia-Lymphoma VirusDOUGLAS W. BLAYNEY, M.D., PRASHANT K. ROHATGI, M.D., WILLIAM HINES, M.D., MARJORIE ROBERT-GUROFF, PH.D., W. CARL SAXINGER, PH.D., WILLIAM A. BLATTNER, M.D., ROBERT C. GALLO, M.D.DOUGLAS W. BLAYNEY, M.D.Search for more papers by this author, PRASHANT K. ROHATGI, M.D.Search for more papers by this author, WILLIAM HINES, M.D.Search for more papers by this author, MARJORIE ROBERT-GUROFF, PH.D.Search for more papers by this author, W. CARL SAXINGER, PH.D.Search for more papers by this author, WILLIAM A. BLATTNER, M.D.Search for more papers by this author, ROBERT C. GALLO, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-99-3-409_1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: We have recently described the "sentinel disease" of infection with the human T-cell leukemia virus (HTLV) as adult T-cell leukemia (1). We were struck by the clinical similarity between adult T-cell leukemia and the nonmalignant disease of unknown cause, Boeck's sarcoid. Both diseases are characterized by lymphadenopathy, lesions, circulating abnormal lymphocytes, and hypercalcemia, and both probably cluster in the southeastern United States. We hypothesized that Boeck's sarcoid (sarcoidosis) may be a nonmalignant result of infection with the human retrovirus, HTLV, because of animal retrovirus models (where primary infection results in differing clinical manifestations), the similarity in clinical...References1. BLAYNEY D, JAFFE E, and BLATTNER W. The human T-cell leukemia/lymphoma virus (HTLV) associated with American adult T-cell leukemia/lymphoma (ATL). Blood. 1983;62:401-5. CrossrefMedlineGoogle Scholar2. SAXINGER W and GALLO R. Application of the indirect ELISA microtest to the detection and surveillance of human T-cell leukemia-lymphoma virus (HTLV). Lab Invest. 1983. (In press). MedlineGoogle Scholar3. MANZARI V, WONG-STAAL F, and FRANCHINI G. Human T-cell leukemia-lymphoma virus (HTLV): cloning of an integrated defective provirus and flanking cellular sequences. Proc Natl Acad Sci. 1983;80:1574-8. CrossrefMedlineGoogle Scholar4. POIESZ B, RUSCETTI F, GAZDAR A, BUNN P, MINNA J, and GALLO R. Detection and isolation of type C retrovirus particles from fresh and cultured lymphocytes of a patient with cutaneous T-cell lymphoma. Proc Natl Acad Sci USA. 1980;77:7415-9. CrossrefMedlineGoogle Scholar5. PINKSTON P, BITTERMAN P, and CRYSTAL R. Spontaneous release of interleukin-2 by lung T lymphocytes in active pulmonary sarcoidosis. N Engl J Med. 1983;308:793-800. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: DOUGLAS W. BLAYNEY, M.D.; PRASHANT K. ROHATGI, M.D.; WILLIAM HINES, M.D.; MARJORIE ROBERT-GUROFF, PH.D.; W. CARL SAXINGER, PH.D.; WILLIAM A. BLATTNER, M.D.; ROBERT C. GALLO, M.D. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byA human T-lymphotropic virus-1 carrier who developed progressive multifocal leukoencephalopathy following immunotherapy for sarcoidosis: a case reportHTLV-1 seroprevalance in sarcoidosis. A clinical and laboratory study in northeast of IranSouthwestern Internal Medicine Conference: Sarcoidosis: Immunology and Clinical ManagementEpidemiology of Human T-cell Leukemia Virus Type I (HTLV-I)THE IMMUNE RESPONSE IN SARCOIDOSISWHAT DOCTORS KNOW ABOUT ALCOHOLISMSarcoidosis and immunocytomaSarcoidosis Progressing to LymphomaFRED ROSENFELT, M.D., WILLIAM YOUNG, M.D., STUART LONKEY, M.D., BARRY ROSENBLOOM, M.D. 1 September 1983Volume 99, Issue 3Page: 409-409KeywordsAnimal models of infectionHIVHuman t lymphotropic virusHypercalcemiaInfectious diseasesLesionsLymphocytesRetrovirusesSarcoidosis ePublished: 1 December 2008 Issue Published: 1 September 1983 PDF downloadLoading ...