tbuckley/cabot-search huggingface dataset:
Therapy Recommendations for HIV-Associated Neurocognitive Disorders
Authors: Jorge L. Zirulnik
Journal: JAMA (2008)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The Multifaceted Challenges of Proteus Syndrome
Authors: Leslie G. Biesecker
Journal: JAMA (2001)

Proteus syndrome is a rare and sporadic disorder that causes postnatal overgrowth of multiple tissues in a mosaic pattern. The overgrowth can involve skin, subcutaneous tissue, connective tissue (including bone), the central nervous system, and viscera. Complications of Proteus syndrome include, among others, progressive skeletal deformities, invasive lipomas, benign and malignant tumors, and deep venous thrombosis with pulmonary embolism. Care of patients with Proteus syndrome presents significant challenges to both physicians and parents because of the various medical as well as psychosocial consequences of the disease. Herein, the case of a 5-year-old patient who manifested a number of these complications is presented. Current knowledge about the diagnosis, natural history, etiology, and management of the disorder is reviewed.
US court rules that insane prisoners can be executed
Authors: S. Gottlieb
Journal: BMJ (2003)

Arkansas can execute mentally ill inmates, as long as medication enables them to understand that they are being executed and the reason for it, a US federal appeals court has ruled.

The decision reopens a longstanding debate about whether mentally ill inmates can be executed if they are sane only while taking drugs. The debate is ripe for the US Supreme Court, attorneys say. If this court hears the case, they say, any decision would set a precedent and would have ramifications across the country.

“It's a tough question,” said J. Thomas Sullivan, a law professor at the …
Consumption of blood products during mechanical circulatory support in children: comparison between ECMO and a pulsatile ventricular assist device
Authors: Brigitte Stiller, Julia Lemmer, Frank Merkle, Vladimir Alexi-Meskishvili, Yuguo Weng, Michael H�bler, Andreas Koster, Thorsten Drews, PeterE. Lange, Roland Hetzer
Journal: Intensive Care Medicine (2004)
Association between Hospital Mortality and Residency Work-Hour Regulations
Authors: Kanaka D. Shetty
Journal: Annals of Internal Medicine (2008)

Letters18 March 2008Association between Hospital Mortality and Residency Work-Hour RegulationsKanaka D. Shetty, MD, MS and Jayanta Bhattacharya, MD, PhDKanaka D. Shetty, MD, MSFrom Stanford University, Stanford, CA 94305.Search for more papers by this author and Jayanta Bhattacharya, MD, PhDFrom Stanford University, Stanford, CA 94305.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-148-6-200803180-00014 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail IN RESPONSE:Dr. Puhan would like us to clarify why we presented results for years 1998 to 2002 in the lower panel of Figure 1. In our primary analysis, we compared outcomes from July 2003 to December 2004 with those from January 2001 to June 2003 and found an improvement in mortality rates of medical teaching patients. However, we were concerned that our findings reflected underlying trends unrelated to the regulations. We tested this by examining whether teaching hospitals improved relative to nonteaching hospitals before the regulations took effect. We found that teaching hospitals did not improve in 2000 to ... Author, Article, and Disclosure InformationAffiliations: From Stanford University, Stanford, CA 94305.Disclosures: None disclosed. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoChanges in Hospital Mortality Associated with Residency Work-Hour Regulations Kanaka D. Shetty and Jayanta Bhattacharya Association between Hospital Mortality and Residency Work-Hour Regulations Milo Puhan Metrics 18 March 2008Volume 148, Issue 6Page: 482KeywordsConflicts of interestDeath ratesResidency ePublished: 18 March 2008 Issue Published: 18 March 2008 Copyright & PermissionsCopyright © 2008 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Interchangeability of conjugated Haemophilus influenzae type b vaccines during primary immunisation of infants
Authors: D. Goldblatt, C. K Fairley, K. Cartwright, E. Miller
Journal: BMJ (1996)

The introduction of conjugate Haemophilus influenzae type b vaccines into the primary infant immunisation schedule in October 1992 has resulted in a dramatic decline in the incidence of infection with invasive Haemophilus influenzae type b in Britain.1 Two different formulations of the conjugate vaccines are licensed in the United Kingdom for administration at 2, 3, and 4 months of age. Because of the lack of data about the safety and immunogenicity of the vaccines when the conjugates are interchanged during primary immunisation, the Department of Health advises against this2 and purchases one formulation for routine use. Reliance on a single supplier for a national immunisation programme is unsatisfactory, and, in the absence of contraindications, the ability to interchange vaccines of different conjugates is highly desirable.

We report the effect on immunogenicity and reactogenicity of interchanging the two different Haemophilus influenzae type b conjugate vaccines during …
Abstract 1436: The Cdk5 activator p39 specifically links muskelin to myosin and regulates stress fiber organization and contraction
Authors: Brajendra K. Tripathi, Douglas R. Lowy, Peggy S. Zelenka
Journal: Cancer Research (2011)

Abstract Cyclin-dependent kinase 5 (Cdk5), a proline-directed serine/threonine protein kinase, regulates signaling pathways implicated in the adhesion and migration of various cell types. Activation of Cdk5 requires its association with its activators p35 or p39. We have recently shown, in lens epithelial cells, that Cdk5 kinase activity regulates rho-dependent myosin phosphorylation, cytoskeletal contraction, and cell migration by controlling Src-p190RhoGAP signaling. In a separate line of investigation, we demonstrated that the N-terminus of p39 binds myosin essential light chain (MLC), while the C-terminus of p39 binds muskelin, a multi-domain scaffolding protein. As both muskelin and MLC have been associated with cytoskeletal organization, the present study seeks to determine whether p39 might serve as an adaptor that links muskelin to myosin and to investigate the possible biological relevance of such an interaction. Immunoprecipitation studies demonstrated that muskelin forms a protein complex with p39, MLC, myosin regulatory light chain (MRLC), and myosin heavy chain II (MHC II). Suppressing expression of p39 abrogated the interaction between muskelin and the myosin subunits, demonstrating that p39 is required to link muskelin to myosin. Immunofluorescence staining showed that muskelin colocalized with MRLC and actin-containing stress fibers. Suppressing muskelin expression with either of two different siRNAs significantly reduced MRLC phosphorylation and disrupted stress fiber organization. Similar effects were observed when Cdk5 activity was inhibited or suppressed. Moreover, suppressing muskelin expression prevented any further reduction of MRLC phosphorylation when Cdk5 activity was blocked, indicating that muskelin plays an important role in Cdk5-dependent regulation of MRLC phosphorylation. The Cdk5 activating protein p39 was necessary and sufficient for Cdk5-dependent regulation of myosin phosphorylation, as suppression of p39, but not p35, significantly reduced MRLC phosphorylation. Together, these results demonstrate that the Cdk5 activating protein p39 specifically links muskelin to myosin and thus, to stress fibers. Therefore, p39 has a dual role in cytoskeletal regulation: on one hand, it is an integral subunit of Cdk5 kinase; on the other, it acts as an adaptor protein to recruit muskelin to stress fibers. Each of these p39 functions is required for myosin phosphorylation, cytoskeletal contraction, and efficient cell migration. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 102nd Annual Meeting of the American Association for Cancer Research; 2011 Apr 2-6; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2011;71(8 Suppl):Abstract nr 1436. doi:10.1158/1538-7445.AM2011-1436
The Immediate Influence of Increased Venous Pressure Upon Resistance to Flow in the Dog's Hind Leg
Authors: FRED A. PHILLIPS, SHIRLEY H. BRIND, MATTHEW N. LEVY
Journal: Circulation Research (1955)

Variations in flow in the presence of a constant arteriovenous pressure difference can only occur when vascular dimensions have been altered, irrespective of the rheological properties of the liquid being perfused. When the vascular bed of the hind leg is subjected to parallel changes in arterial and venous pressures, higher absolute values of pressure result in an enhancement of flow. This constitutes convincing evidence to indicate that certain vessels which offer a significant resistance to blood flow are distensible.
Effect of Circulatory Changes on the Pulmonary Compliance of Normal Subjects and Patients with Mitral Stenosis
Authors: W. W. PRYOR, J. B. HICKAM, H. O. SIEKER, E. B. PAGE
Journal: Circulation (1957)

Fulfillment by the lungs of their bellows function depends largely on their resiliency and elasticity. Unless the lungs can readily comply with the changes in the thoracic cage during inspiration and expiration, ventilation will be seriously impaired. Pulmonary compliance is expressed as the ratio of lung volume in liters to intraesophageal pressure in centimeters of water. The present study is concerned with the role of pulmonary vascular engorgement in reducing compliance in normal subjects and in patients with mitral stenosis.
Have Polio-Free Countries Lost Sight of Need to Keep Vaccination Rates High?
Authors: Rebecca Voelker
Journal: JAMA (2010)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Fungal protein MGL_1304 in sweat is an allergen for atopic dermatitis patients
Authors: Takaaki Hiragun, Kaori Ishii, Makiko Hiragun, Hidenori Suzuki, Takanobu Kan, Shoji Mihara, Yuhki Yanase, Joachim Bartels, Jens-M. Schröder, Michihiro Hide
Journal: Journal of Allergy and Clinical Immunology (2013)
Temporal arteritis in association with the Guillain-Barre syndrome.
Authors: R N Corston
Journal: BMJ (1980)

Mean (11 SD) vascular permeability (as mean areas of blueing) caused by cultured lymphocytes taken from normal subjects and from patients during relapse of minimal change nephropathy before treatment with steroids Mean areas of blueing (mm2) R,: reconstituted supernatant from cultures from controls .32-8±22-2 R,: reconstituted supematant from cultures from patients .105-4±32-7 S1: supernatant from PHA stimulated cultures from controls .60-2±38-1 S,: supernatants from PHA-stimulated cultures from patients .113-8±24-9 PHA = Phytohaemagglutinin.that for PHA-stimulated supernatant (S v S2; p < 0.005).In seven control assays S was significantly higher than R1 (p < 0 05, Student's dependent t test).The difference in values for R2 and S2 was not significant; nor was there any difference in production of vascular permeability factor between cells taken from patients in remission and those taken from controls.
Blood&amp;ndash;Borne RT&amp;ndash;PCR Assay for Prostasin&amp;ndash; Specific Transcripts to Identify Circulating Prostate Cells in Cancer Patients
Authors: Abder Laribi, Abder Laribi, Pierre Berteau, Pierre Berteau, Jean Luc Gala, Jean Luc Gala, Pascal Eschw&egrave;ge, Pascal Eschw&egrave;ge, Gerard Benoit, Gerard Benoit, Bertrand Tombal, Bertrand Tombal, Fran&ccedil;ois Schmitt, Fran&ccedil;ois Schmitt, Sylvain Loric, Sylvain Loric
Journal: European Urology (2001)
Can We Clinically Measure Infarction Size?
Authors: Robert Roberts
Journal: JAMA (1979)

SINCE the advent of the coronary care unit (CCU) in 1962, the in-hospital mortality of patients with acute myocardial infarction has been notably reduced, predominantly because of better management of ventricular arrhythmias. Despite adequate antiarrhythmic therapy, there remains a 15% to 25% acute mortality that is related primarily to pump failure, a major determinant of which is the extent of myocardial damage (infarct size). Postmortem studies have shown that patients dying of cardiogenic shock exhibit 40% or more destruction of the myocardium. Clearly, therapeutic efforts in the modern CCU must be directed toward reducing the extent of myocardial damage associated with myocardial infarction. Pioneering studies by Braunwald and others<sup>1</sup>suggested that the development of myocardial damage is a dynamic event that can be favorably altered, notably by decreasing the imbalance between myocardial oxygen supply and demand. This provided the impetus for an area of research, namely, protection of ischemic myocardium,
Sarcopenia—Understanding the Dynamics of Aging Muscle
Authors: Ronenn Roubenoff
Journal: JAMA (2001)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Preimplantation HLA Testing
Authors: Yury Verlinsky
Journal: JAMA (2004)

ContextPreimplantation genetic diagnosis (PGD) has become an option for couples for whom termination of an affected pregnancy identified by traditional prenatal diagnosis is unacceptable and is applicable to indications beyond those of prenatal diagnosis, such as HLA matching to affected siblings to provide stem cell transplantation.ObjectiveTo describe preimplantation HLA typing, not involving identification of a causative gene, for couples who had children with bone marrow disorders at need for HLA-matched stem cell transplantation.Design, Setting, and ParticipantsHLA matching procedures conducted at a single site during 2002-2003 in an in vitro fertilization program for 9 couples with children affected by acute lymphoid leukemia, acute myeloid leukemia, or Diamond-Blackfan anemia requiring HLA-matched stem cell transplantation. In 13 clinical cycles, DNA in single blastomeres removed from 8-cell embryos following in vitro fertilization was analyzed for HLA genes simultaneously with analysis for short tandem repeats in the HLA region to select and transfer only those embryos that were HLA matched to affected siblings.Main Outcome MeasuresResults of HLA matching and pregnancy outcome.ResultsAs a result of testing a total of 199 embryos, 45 (23%) HLA-matched embryos were selected, of which 28 were transferred in 12 clinical cycles, resulting in 5 singleton pregnancies and birth of 5 HLA-matched healthy children.ConclusionThis is the first known experience of preimplantation HLA typing performed without PGD for a causative gene, providing couples with a realistic option of having HLA-matched offspring to serve as potential donors of stem cells for their affected siblings.
Abstract 3897: A difference of HER-2 amplification index between luminal B and HER2 enriched subgroup
Authors: Soohyeon Lee, Ja Seung Koo, Byung Woo Park, Seung Il Kim, Se Ho Park, Gun Min Kim, Se Hyun Kim, Joo Hang Kim, Ju Hyuk Sohn
Journal: Cancer Research (2011)

Abstract Background: The aim of this study was to compare the HER2 gene amplification index (AI) of luminal B and HER-2 enriched breast cancers using fluorescence in situ hybridization (FISH). Methods: Out of 753 patients with breast cancer who were tested HER2 status by FISH between Jan 2004 to Dec 2009, 224 HER2 amplified patients were available for this study. HER2-amplified breast cancers constitute a heterogenous group that may be subdivided according to their ER status: HER2 amplified ER-positive breast carcinomas that fall into the luminal B group; and HER2 amplified ER-negative cancers which form a distinct molecular subtype, known as the HER2 enriched group according to hormone status by immunohistochemistry and HER2 amplification confirmed as HER2/CEP17 ratio by FISH. A difference of HER2 AI was analyzed between luminal B and HER-2 enriched group. Clinicopathologic parameters were analyzed. Results: Among the HER2 amplified patients, the proportion of luminal B and HER2 breast cancer was 53.5% (N=120) and 46.5% (N=104), respectively. Early breast cancer patients were 84.8% (N=190) and metastatic breast cancer patients were 15.2% (N=34). HER-2 AI of luminal B group and HER2 enriched group were 4.99 and 5.84 respectively, which values showed the quantitative difference statistically significant (p=0.003). However, increasing value of HER2 AI was not associated with a better overall survival or progression free survival. In luminal B group, a significant difference of HER2 AI between ER/PR +/+ subgroup and ER/PR +/- subgroup existed which were 4.02 and 5.32, respectively (p=0004). Conclusions: The HER2 AI of HER2 enriched group was higher than that of luminal B group statistically significant. It was not clear whether the extent of HER-2 amplification relates to the survival benefit of treatment in HER-2 positive breast cancer. Further research to understand how the level of HER2 amplification is related to prognosis is warranted in order to understand the breast cancer biology associated with the intrinsic subtypes. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 102nd Annual Meeting of the American Association for Cancer Research; 2011 Apr 2-6; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2011;71(8 Suppl):Abstract nr 3897. doi:10.1158/1538-7445.AM2011-3897
Cardiopulmonary receptor reflexes in normotensive athletes with cardiac hypertrophy.
Authors: C Giannattasio, G Seravalle, G B Bolla, B M Cattaneo, J Cléroux, C Cuspidi, L Sampieri, G Grassi, G Mancia
Journal: Circulation (1990)

Cardiopulmonary receptor control of the circulation is impaired in a variety of diseases having cardiac hypertrophy as a common feature. Whether this also occurs in the so-called "physiological" cardiac hypertrophy of the athlete, however, is unknown. We studied nine sedentary healthy subjects and 19 age-matched professional runners or hammer throwers who had trained at least 2 hours per day, 5 days per week for 7 years. The left ventricular mass index (echocardiography) was 99 +/- 7.4 and 135 +/- 5.9 g/m2 in the two groups, respectively. Cardiopulmonary receptor stimulation and deactivation were obtained by increasing and reducing left ventricular end-diastolic diameter for 5 minutes by leg raising and lower body negative pressure, keeping both stimuli at a level not affecting blood pressure and heart rate. In the sedentary healthy subjects, forearm vascular resistance (the ratio between mean arterial pressure and forearm blood flow) and plasma norepinephrine fell during leg raising (forearm vascular resistance, -7 +/- 1.7 units; norepinephrine, -57.4 +/- 1.4 pg/ml) and increased during lower, body negative pressure (forearm vascular resistance, 20 +/- 5.3 units; norepinephrine, 97.7 +/- 21.5 pg/ml). For similar or greater alterations in left ventricular end-diastolic diameter, the correspondent changes observed in the professional runners or hammer throwers were -5.3 +/- 1.3 units (forearm vascular resistance), -35.4 +/- 9.6 pg/ml (norepinephrine), 9.1 +/- 1.4 units (forearm vascular resistance), and 30.9 +/- 6.9 pg/ml (norepinephrine). This represented an attenuation of 25%, 38%, 55%, and 68%, respectively (p less than 0.01), of the control response.(ABSTRACT TRUNCATED AT 250 WORDS)
Efficacy of rubella vaccination.
Authors: E D Pereira, H N Macdonald, M H Hambling
Journal: BMJ (1978)

for skilled advice on occupational health matters, and in consequence many previously neglected environmental problems have come to light which call for medical help.It is the duty of those who undertake to advise them to make it plain that these are the important tasks, and that occupational medicine does not consist of routine examinations of new employees on the pretence that the doctor can forecast future sickness absence experience or survival.