tbuckley/cabot-search huggingface dataset:
Cardiovascular and renal hemodynamic effects of intravenous infusions of the selective DA1 agonist, fenoldopam, used alone or in combination with dopamine and dobutamine.
Authors: N A Lass, D Glock, L I Goldberg
Journal: Circulation (1988)

Fenoldopam (0.1 and 0.2 microgram/kg/min i.v.) was administered to pentobarbital-anesthetized dogs alone and combined with dopamine (DA) and dobutamine. Renal blood flow, heart rate, and mean arterial pressure were measured. Both dosages of fenoldopam increased renal blood flow without altering blood pressure, similar to the effects of DA (1 and 2 micrograms/kg/min). Administration of fenoldopam with only DA (1 microgram/kg/min) produced further increase in renal blood flow. After administration of phenoxybenzamine (15 mg/kg i.v.), DA produced significant increments in renal blood flow and reductions in renal vascular resistance when compared with experiments without phenoxybenzamine, suggesting even low dosages of DA exert alpha-adrenoceptor agonist activity. Dobutamine (2 and 4 micrograms/kg/min) increased renal blood flow about 37% of that produced by DA. Fenoldopam added to dobutamine produced similar increments in renal blood flow as DA. Fenoldopam did not affect the increase in cardiac contractile force produced by DA and dobutamine. Thus, fenoldopam alone or in combination with DA had no advantage over 2 and 4 micrograms/kg/min DA to further increase renal blood flow. In contrast, fenoldopam with dobutamine produced greater increments in cardiac contractile force than DA and equivalent increases in renal blood flow as DA.
Food and the Housewife
Authors: V. H. Mottram
Journal: BMJ (1940)

Even if the scientists knew the whole truth about the work that foods do in the body and the way in which they dlo it, it would be almost impossible for the housewife to cater scientifically.She would have to cater for many different daily needs of calories, of two types of proteins, of at least four inorganic substances-two metals and two non-metals-and of seven different vitamins.It is probable that no person could carry in his head the calorie values of the fifty or sixty different foods which we eat, their percentage compositions as regards first-and second-class proteins, the amounts of calcium, iron, iodine, and phosphorus in those foods, and the distribution of the
Tc-99m Pertechnetate Accumulation in Osteotomy Site
Authors: TSUNEO HIRANO, KAZUHIDE ICHIKAWA, MINORU YOKOYAMA, YASUYOSHI YAMAMOTO, HIROSHI NARUKO
Journal: Clinical Nuclear Medicine (1995)

A 43-year-old man had anterior fixation surgery with a bony graft for disc hernlation at the fifth and sixth cervical intervertebral disc level 40 days earlier. He had abdominal discomfort with tarry stools for 1 week, and his hemoglobin rapidly decreased from 13.7 to 4.1 g–dl. Tc-99m pertechnetate scintigraphy was performed to search for ectopic gastric mucosa in a Meckel's diverticulum. Dynamic images demonstrated a large area of increased accumulation in the left lateral pelvis and there was a small area of decreased uptake noted within this uptake region. Plain radiographs of the pelvis revealed a previous osteotomy site with a radiopaque ceramic spacer.
Cardiovascular Complications of Guanidine Hydrochloride
Authors: KENNETH K. NAKANO
Journal: Annals of Internal Medicine (1972)

Letters, Comments, and Corrections1 October 1972Cardiovascular Complications of Guanidine HydrochlorideKENNETH K. NAKANO, M.D., H. RICHARD TYLER, M.D.KENNETH K. NAKANO, M.D.Search for more papers by this author, H. RICHARD TYLER, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-77-4-658 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: We wish to report a case of cardiac arrhythmias and hypotension occurring in conjunction with guanidine hydrochloride therapy in a patient with an oat cell carcinoma of the lung and the myasthenic syndrome.Guanidine hydrochloride has been shown to enhance the release of acetylcholine from nerve endings and to improve significantly the muscular weakness associated with the myasthenic syndrome of Lambert and Rooke (1). It has also been administered in cases of botulism and resulted in some improvement of muscular function (2). Despite abundant evidence in experimental animals that significant cardiovascular disorders can occur with this drug,...References1. LAMBERT E and ROOKE E: Myasthenic state and lung cancer, in The Remote Effects of Cancer on the Nervous System, edited by BRAIN R, NORRIS FH JR. New York, Grune & Stratton, 1965, pp. 67-80 Google Scholar2. CHERINGTON M and RYAN D: Treatment of botulism with guanidine. N Engl J Med 282:195-197, 1970 CrossrefMedlineGoogle Scholar3. BURNS D and WATSON A: The effect of thyroparathyroidectomy on the heart and circulation. II. Action of guanidine on the heart of the frog. J Physiol 53:386-390, 1920 CrossrefMedlineGoogle Scholar4. MINOT A: A comparison of the effect of calcium and of atropine and scopolamine on the plasma loss and on the general symptoms of guanidine intoxication. J Pharmacol Exp Ther 65:243-252, 1939 Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: KENNETH K. NAKANO, M.D.; H. RICHARD TYLER, M.D.Affiliations: Section of Neurology Peter Bent Brigham Hospital Boston, Mass. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 October 1972Volume 77, Issue 4Page: 658-658KeywordsAcetylcholineArrhythmiaBotulismCardiovascular therapyDrugsHypotensionMuscular weaknessNerve endingsSmall cell lung cancer ePublished: 1 December 2008 Issue Published: 1 October 1972 PDF downloadLoading ...
Effects of halothane on the intramyocardial pressure of the canine left ventricle
Authors: D. NEMATZADEH, Y. D KIM, J. C ROSE, P. H WOLF, T. E MACNAMARA, P. A KOT
Journal: Cardiovascular Research (1986)

Journal Article Effects of halothane on the intramyocardial pressure of the canine left ventricle Get access DAVID NEMATZADEH, DAVID NEMATZADEH **From the Departments of Physiology and Biophysics, Washington DC, USA Search for other works by this author on: Oxford Academic PubMed Google Scholar YOUNG D KIM, YOUNG D KIM †From the Departments of Anesthesia, Georgetown University Medical Center, Washington DC, USA Search for other works by this author on: Oxford Academic PubMed Google Scholar JOHN C ROSE, JOHN C ROSE **From the Departments of Physiology and Biophysics, Washington DC, USA Search for other works by this author on: Oxford Academic PubMed Google Scholar PAMELA H WOLF, PAMELA H WOLF **From the Departments of Physiology and Biophysics, Washington DC, USA Search for other works by this author on: Oxford Academic PubMed Google Scholar THOMAS E MACNAMARA, THOMAS E MACNAMARA †From the Departments of Anesthesia, Georgetown University Medical Center, Washington DC, USA Search for other works by this author on: Oxford Academic PubMed Google Scholar PETER A KOT PETER A KOT **From the Departments of Physiology and Biophysics, Washington DC, USA Search for other works by this author on: Oxford Academic PubMed Google Scholar Cardiovascular Research, Volume 20, Issue 4, April 1986, Pages 275–281, https://doi.org/10.1093/cvr/20.4.275 Published: 01 April 1986
Primary peritoneal pregnancy.
Authors: A. G. Johnson
Journal: BMJ (1968)

Preliminary Communications others the cell surfaces were covered apparently by swollen, stunted microvilli of about 0.3 ,, diameter.As in control jejunum, holes or openings could also be seen in these specimens (Fig. 6), and may represent the orifices of subjacent goblet cells.Sometimes, as in Fig. 7, a plug of mucus-like material could be seen at these openings.The corru- gations which had been seen running round the villi in control small intestine were not evident in the coeliac biopsies.We are grateful to Professor C. C. Booth, whose patients we have studied, for his interest and helpful criticisms.
CARDIOVASCULAR RISK IN TYPE 2 DIABETES MELLITUS: THE ROLE OF AN UNUSUAL T-CELL POPULATION
Authors: simona giubilato, Salvatore Brugaletta, Costantino Smaldone, Vincenzo Pazzano, Dario Pitocco, Giovanni Ghirlanda, Luigi M. Biasucci, Giovanna Liuzzo, Filippo Crea
Journal: Journal of the American College of Cardiology (2010)
Human homologues of Delta-1 and Delta-4 function as mitogenic regulators of primitive human hematopoietic cells
Authors: Francis N. Karanu, Barbara Murdoch, Tomoyuki Miyabayashi, Mitsuhara Ohno, Masahide Koremoto, Lisa Gallacher, Dongmei Wu, Akira Itoh, Seiji Sakano, Mickie Bhatia
Journal: Blood (2001)
Identification of the gene encoding the major latency-associated nuclear antigen of the Kaposi's sarcoma-associated herpesvirus.
Authors: D H Kedes, M Lagunoff, R Renne, D Ganem
Journal: Journal of Clinical Investigation (1997)

Over 85% of patients with Kaposi's sarcoma (KS) are seropositive for antibodies to the latency-associated nuclear antigen (LANA) expressed in B cell lines infected with Kaposi's sarcoma-associated herpesvirus (KSHV). The presence of antibodies to LANA strongly correlates with the risk of developing the disease. However, the identity of the protein(s) comprising LANA and the corresponding gene(s) has remained unclear. To identify potential latent gene candidates for LANA, we probed total RNA extracted from BCBL-1 cells (a B cell line latently infected with KSHV) using lambda clones that span the KSHV genome. One region encoding latent transcripts spanned KSHV open reading frames (orfs) 71 (K13), 72 (v-cyclin), and 73. Among these, however, only orf 73, when expressed in heterologous mammalian cell systems, reacted with KSHV antibody-positive human sera, resulting in a punctate nuclear staining pattern reminiscent of LANA in BCBL-1 cells. Furthermore, extracts from cells expressing the orf 73 protein product specifically blocked the binding of KS patient antibodies to LANA. Finally, seroreactivity with recombinant orf 73 protein exactly paralleled reactivity with classical LANA as expressed in BCBL-1 cells, both in KS patients and in other groups. Together, these data support the identification of KSHV orf 73 as the gene encoding the dominant immunogenic component of LANA.
Calcitriol but no other metabolite of vitamin D is essential for normal bone growth and development in the rat.
Authors: A M Parfitt, C H Mathews, R Brommage, K Jarnagin, H F DeLuca
Journal: Journal of Clinical Investigation (1984)

To determine the relative importance of different metabolites of vitamin D in bone growth and development, weanling male rat pups suckled by vitamin D-deficient mothers were given either calcitriol (1,25-dihydroxycholecalciferol) by continuous subcutaneous infusion, oral calcidiol (25-hydroxycholecalciferol), or oral 24,24-difluoro-25-hydroxycholecalciferol, a synthetic compound that can undergo 1-hydroxylation but not 24-hydroxylation, as their sole source of vitamin D for 40 d. Pups raised in the same manner, but given no vitamin D, served as controls. The three metabolites compared were given in doses that restored normal plasma calcium levels and normal increments in body weight. After in vivo double tetracycline labeling, bone histomorphometry by standard methods was performed on one femur and one tail vertebra. There were no significant differences between the three metabolite-treated groups in length, periosteal or endosteal diameter, cortical cross-sectional area, cortical porosity, osteoid thickness and volume, appositional rate and bone formation rate in the femur, or in qualitative and quantitative indices of endochondral ossification in the tail vertebra. All three groups differed markedly from the untreated controls with respect to all measurements. Collectively, the data indicate that neither calcidiol nor any 24-hydroxylated metabolite of calcidiol is needed in the rat (other than as a precursor) for longitudinal or transverse bone growth, for normal endochondral ossification, or for normal periosteal and endosteal formation, mineralization, and resorption of bone. Calcitriol was fully active with respect to each of the indices listed when given in a manner resembling its continuous endogenous production by the kidney, suggesting that previous reports of incomplete skeletal response to calcitriol result from its rapid clearance and infrequent oral administration. We demonstrated that calcitriol is the only metabolite that is both necessary and sufficient for normal bone growth and development in the rat, but our data do not indicate the extent to which its beneficial skeletal effects were mediated by direct action on bone, either of calcitriol itself or of some metabolite thereof, or by restoration of normal plasma levels of calcium and phosphate.
Ga-67 Scintigraphy in a Child With Adrenocortical Carcinoma
Authors: ROBERT HOWMAN-GILES, LUCIANNO DALLA POZZA, ROGER UREN
Journal: Clinical Nuclear Medicine (1993)

Adrenocortical carcinoma is a rare malignancy in childhood and often presents with a large abdominal mass and precocious puberty. The tumor is often advanced at the time of diagnosis. Radiological techniques are the main imaging modalities for assessment of the primary tumor. Ga-67 scintigraphy has been used in other pediatric solid tumors, however, no data were available for this tumor in childhood. A case of a 2.5-year-old male with a Ga-67 avid adrenocortical carcinoma is reported in which Ga-67 scintigraphy was very useful in detecting recurrence of the tumor and in assessing response to therapy.
Dipyridamole-lnduced Myocardial Ischemia
Authors: Theodore N. Keltz
Journal: JAMA (1987)

Angina and ischemic electrocardiographic changes occurred after administration of oral dipyridamole in four patients awaiting urgent myocardial revascularization procedures. To our knowledge, this has not previously been reported as a side effect of preoperative dipyridamole therapy, although dipyridamole-induced myocardial ischemia has been demonstrated to occur in animals and humans with coronary artery disease. Epicardial coronary collateral vessels were demonstrated in all four patients; a coronary "steal" phenomenon may be the mechanism of the dipyridamole-induced ischemia observed. (<i>JAMA</i>1987;257:1516-1517)
Abstract 2150: Chemopreventive effects of black raspberries in endometrial cancer
Authors: Jo-Hsin Chen, Irene Aguilera-Barrantes, Chieh-Ti Kuo, Leena Hilakivi-Clarke, Gary D. Stoner, Janet S. Rader, Yi-Wen Huang
Journal: Cancer Research (2014)

Abstract Endometrial cancer is the most common type of gynecologic cancer and annually comprises 3% of all cancer deaths of women in the United States. Additionally, ∼80% of cases are type I endometrial cancer, mainly associated with Pten abnormalities. It was estimated that up to 90% of type I endometrial cancer patients are overweight/obese. Therefore, a regimen to prevent obesity associated tumorigenesis is the most important for type I endometrial cancer. In the current study, the Pten heterozygous (+/-) female mice were used as the model, to study the potentially chemopreventive effects by black raspberries (BRBs). At 3-4 weeks old, Pten (+/-) and wild type female mice were divided into four treatment groups, fed with either AIN-93G control diet (CD), CD with 5% BRBs, 58% fat to induce obesity (HF),or HF with 5% BRBs. All of mice were euthanized at 28 weeks old. In wild type mice, no malignant lesion was identified. In Pten (+/-) mice, HF diet increased 10% focal glandular hyperplasia with atypia lesions when compared with CD diet. Dietary administration of BRBs decreased 19% focal glandular hyperplasia with atypia lesions when compared with CD group. Specifically, BRBs in HF diet inhibited 32% obesity-induced endometrial malignant lesions and significantly lowed lesion multiplicity. Furthermore, cytokine profiles in plasma by Bio-Plex Assay revealed dietary BRBs decreased IL-1β and IL-17A, and lowed TNF-α and GM-CSF when compared with CD and HF group, respectively. In conclusion, this study for the first time suggested BRBs are chemopreventive for obesity-induced endometrial tumorigenesis. Citation Format: Jo-Hsin Chen, Irene Aguilera-Barrantes, Chieh-Ti Kuo, Leena Hilakivi-Clarke, Gary D. Stoner, Janet S. Rader, Yi-Wen Huang. Chemopreventive effects of black raspberries in endometrial cancer. [abstract]. In: Proceedings of the 105th Annual Meeting of the American Association for Cancer Research; 2014 Apr 5-9; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2014;74(19 Suppl):Abstract nr 2150. doi:10.1158/1538-7445.AM2014-2150
Electronic Patient Data Acquisition Tablet (ePDAT) Provides Customized, Flexible Scheduling For Collecting Patient Reported Outcomes (ePRO) With High Usability and Compliance Ideal For Use In Single and Multicenter Environmental Exposure Chamber Studies
Authors: Dan Wilson, Piyush Patel, Konrad Boczula, AnneMarie Salapatek
Journal: Journal of Allergy and Clinical Immunology (2014)
Mechanisms of Pancreatic Islet Cell Destruction Dose‐Dependent Cytotoxic Effect of Soluble Blood Mononuclear Cell Mediators on Isolated Islets of Langerhans
Authors: T. Mandrup‐Poulsen, K. Bendtzen, J. Nerup, J. Egeberg, J. H. Nielsen
Journal: Allergy (1986)

Supernatants of peripheral blood mononuclear cells from healthy human donors stimulated with recall antigen (purified protein derivative of tuberculin) or lectin (phytohaemagglutinin) markedly inhibited the insulin release from isolated human and rat islets of Langerhans, and decreased rat islet contents of insulin and glucagons in a dose‐dependent manner. A maximal effect on islet function was obtained with supernatant concentrations down to 5%. Supernatants of mononuclear cells stimulated with tuberculin were more potent than supernatants produced by lectin stimulation. Culture medium reconstituted with tuberculin or phytohaemagglutinin did not impair islet function. Electron microscopy demonstrated that supernatants were cytotoxic to islet cell. The cytotoxic mononuclear cell mediator(s) was non‐dialysable, sensitive to heating to 56°C, labile even when stored at ‐70°C, but stable when lyophilised.
Common genes underlying asthma and COPD? Genome-wide analysis on the Dutch hypothesis
Authors: Joanna Smolonska, Gerard H. Koppelman, Cisca Wijmenga, Judith M. Vonk, Pieter Zanen, Marcel Bruinenberg, Ivan Curjuric, Medea Imboden, Gian-Andri Thun, Lude Franke, Nicole M. Probst-Hensch, Peter Nürnberg, Roland A. Riemersma, Constant P. van Schayck, Daan W. Loth, Guy G. Brusselle, Bruno H. Stricker, Albert Hofman, André G. Uitterlinden, Lies Lahousse, Stephanie J. London, Laura R. Loehr, Ani Manichaikul, R. Graham Barr, Kathleen M. Donohue, Stephen S. Rich, Peter Pare, Yohan Bossé, Ke Hao, Maarten van den Berge, Harry J.M. Groen, Jan-Willem J. Lammers, Willem Mali, H. Marike Boezen, Dirkje S. Postma
Journal: European Respiratory Journal (2014)

Asthma and chronic obstructive pulmonary disease (COPD) are thought to share a genetic background ("Dutch hypothesis"). We investigated whether asthma and COPD have common underlying genetic factors, performing genome-wide association studies for both asthma and COPD and combining the results in meta-analyses. Three loci showed potential involvement in both diseases: chr2p24.3, chr5q23.1 and chr13q14.2, containing DDX1, COMMD10 (both participating in the nuclear factor (NF) κβ pathway) and GNG5P5, respectively. Single nucleotide polymorphisms (SNPs) rs9534578 in GNG5P5 reached genome-wide significance after first replication phase (p=9.96×10(-9)). The second replication phase, in seven independent cohorts, provided no significant replication. Expression quantitative trait loci (eQTL) analysis in blood cells and lung tissue on the top 20 associated SNPs identified two SNPs in COMMD10 that influenced gene expression. Inflammatory processes differ in asthma and COPD and are mediated by NF-κβ, which could be driven by the same underlying genes, COMMD10 and DDX1. None of the SNPs reached genome-wide significance. Our eQTL studies support a functional role for two COMMD10 SNPs, since they influence gene expression in both blood cells and lung tissue. Our findings suggest that there is either no common genetic component in asthma and COPD or, alternatively, different environmental factors, e.g. lifestyle and occupation in different countries and continents, which may have obscured the genetic common contribution.
Receptor and postreceptor defects contribute to the insulin resistance in noninsulin-dependent diabetes mellitus.
Authors: O G Kolterman, R S Gray, J Griffin, P Burstein, J Insel, J A Scarlett, J M Olefsky
Journal: Journal of Clinical Investigation (1981)

We have assessed the mechanisms involved in the pathogenesis of the insulin resistance associated with impaired glucose tolerance and Type II diabetes mellitus by exploring, by means of the euglycemic glucose-clamp technique, the in vivo dose-response relationship between serum insulin and the overall rate of glucose disposal in 14 control subjects; 8 subjects with impaired glucose tolerance, and 23 subjects with Type II diabetes. Each subject had at least three studies performed on separate days at insulin infusion rates of 40, 120, 240, 1,200, or 1,800 mU/M2 per min. In the subjects with impaired glucose tolerance, the dose-response curve was shifted to the right (half-maximally effective insulin level 240 vs. 135 microunits/ml for controls), but the maximal rate of glucose disposal remained normal. In patients with Type II diabetes mellitus, the dose-response curve was also shifted to the right, but in addition, there was a posal. This pattern was seen both in the 13 nonobese and the 10 obese diabetic subjects. Among these patients, an inverse linear relationship exists (r = -0.72) so that the higher the fasting glucose level, the lower the maximal glucose disposal rate. Basal rates of hepatic glucose output were 74 +/- 4, 82 +/- 7, 139 +/- 24, and 125 +/- 16 mg/M2 per min for the control subjects, subjects with impaired glucose tolerance, nonobese Type II diabetic subjects, and obese Type II diabetic subjects, respectively. Higher serum insulin levels were required to suppress hepatic glucose output in the subjects with impaired glucose tolerance and Type II diabetics, compared with controls, but hepatic glucose output could be totally suppressed in each study group. We conclude that the mechanisms of insulin resistance in patients with impaired glucose tolerance and in patients with Type II noninsulin-dependent diabetes are complex, and result from heterogeneous causes. (a) In the patients with the mildest disorders of carbohydrate homeostasis (patients with impaired glucose tolerance) the insulin resistance can be accounted for solely on the basis of decreased insulin receptors. (b) In patients with fasting hyperglycemia, insulin resistance is due to both decreased insulin receptors and postreceptor defect in the glucose mechanisms. (c) As the hyperglycemia worsens, the postreceptor defect in peripheral glucose disposal emerges and progressively increases. And (d) no postreceptor defect was detected in any of the patient groups when insulin's ability to suppress hepatic glucose output was measured.
Edmund John Dowling
Authors: Jonathan Dowling
Journal: BMJ (2004)

Forde Cayley went from medical school straight into service in wartime France and then to Singapore.Captured by the Japanese, he was taken to the infamous River Kwai.The horrors he had witnessed never left him, but he believed in reconciliation, not hatred.As a postwar pioneer of drug treatment for tuberculosis, he took up the respiratory medicine post that he held until retirement.His spare time was divided between BMA activities, his work as a lay reader, and in his prolific vegetable plot.Predeceased by his wife, Eileen, he leaves two sons and three grandsons.