tbuckley/cabot-search huggingface dataset:
A new cholangiojejunostomy for multiple biliary ductal openings: A study in pigs
Authors: Hong-qiang Yang, Shuai Xiang, Wan Yee Lau, Zhi-yong Huang, Hong-ping Luo, Qi Cheng, Lin Chen, Hong Wang, Guo-ping Wang, Xiao-ping Chen
Journal: International Journal of Surgery (2015)
Abstract MP86: The Joint Effect of Outdoor Recreational Activity and 25-Hydroxyvitamin D on Cardiovascular Mortality in THE NHANES III Population
Authors: Macarius Donneyong, Carlton A Hornung
Journal: Circulation (2013)

Purpose Recreational physical activity (PA) reduces the risk of cardiovascular disease (CVD) morbidity and mortality. Outdoor-based recreational physical activities (ORA) have been reported to be associated with elevated 25(OH)D levels. We investigate the joint effects of frequent ORA and 25(OH)D levels on the risk of CVD mortality and the modifying effects of 25(OH)D. Methods Our sample consisted of 13,031 nationally representative adults (20 - 90 years old) free from CVD and cancer at baseline in the NHANES III (1988 - 1994) linked mortality dataset with follow-up mortality data through 2006. CVD mortality was based on reported deaths with corresponding ICD-10 codes for CVD as underlying cause of death. ORA was defined as self-reported participation in recreational physical activities considered to have occurred outdoors in the past month. Time to CVD mortality was estimated from multivariable adjusted Cox proportional hazards (CPH) models. A joint effects model was used in estimating multiplicative and additive interaction between ORA and 25(OH)D. Results A crude unweighted CVD mortality rate of 7.4% (964/13,031) occurred during a median follow-up of 14.33 years. Frequency of ORA &lt;5 in the past month (HR=1.38, 95%CI:1.09 - 1.75) and 25(OH)D &lt;30 ng/mL (HR=1.28, 95%CI:1.01 - 1.60) were associated with increased risk of CVD mortality compared to ORA ≥5 and 25(OH)D ≥30 ng/mL respectively, in a multivariable adjusted CPH model. In the joint effects model, frequency of ORA &lt;5 and 25(OH)D &lt;30 ng/mL (HR=1.81, 95%CI:1.05 - 3.10) and frequency of ORA &lt;5 and 25(OH)D ≥30 ng/mL (HR=1.33, 95%CI:1.02 - 1.73) were associated with elevated risk of CVD mortality compared to the joint effects of ORA ≥5 and 25(OH)D ≥30 ng/mL. The joint effects model indicated the presence of multiplicative interaction. The synergy index, 1.52 (95%CI:0.31 - 7.41) suggested presence of additive interaction even though not statistically significant. Conclusion Lower frequency of ORA and serum 25(OH)D levels were jointly associated with elevated risk of CVD mortality. Serum 25(OH)D modified the risk of CVD mortality associated with lower frequency of outdoor-based recreational activities.
Measuring standards of care for early breast cancer in an insured population.
Authors: B E Hillner, M K McDonald, L Penberthy, C E Desch, T J Smith, P Maddux, W P Glasheen, S M Retchin
Journal: Journal of Clinical Oncology (1997)

PURPOSE To demonstrate the use of a combined data base to evaluate the care for local/regional invasive breast cancer in a large insured population of women aged less than 64 years. PATIENTS AND METHODS We linked the procedural and hospital claims from Blue Cross Blue Shield (BCBS) of Virginia with clinical stage data from the Virginia Cancer Registry (VCR) from 1989 to 1991. A total of 918 women were assessed with a median age of 50 years; 68% had tumors less than 2 cm, 30% had positive axillary nodes, and 68% were assessed as having local summary stage. A quality-of-care "report card" was used based on standards of care from international Consensus Conferences. RESULTS Eight percent had a mastectomy as the initial biopsy procedure. Sixty-nine percent of women ultimately underwent mastectomy. Of those women who underwent lumpectomy, 86% had subsequent radiation. Within 3 months of diagnosis, 43% had a bone scan and 20% a computed tomography (CT) scan. Of women with positive axillary lymph nodes, 83% aged less than 51 years and 52% aged 51 to 64 years received chemotherapy. Fifty-six percent of all women had claims from a medical oncologist. Of women having a total mastectomy, 27% had claims from a plastic surgeon. Sixty-six percent to 76% of women had a mammogram, 24% a bone scan, and 14% a CT scan in the 0-18 and 18-36 month intervals following primary treatment. CONCLUSION This study confirms the feasibility of linking sources of data that provide complementary information needed to develop measurements regarding standards of quality and efficiency of oncologic care. This report should serve as an initial benchmark while we await reports from other populations to define the best practice.
Impact of CPAP in the physical exercise tolerance and sympathetic-vagal balance of patients with chronic heart failure
Authors: Hugo Valverde Reis, Eliete Ferreira Pinto, Audrey Borghi-Silva, Michel Silva Reis
Journal: European Respiratory Journal (2013)

Chronic heart failure (CHF) lead peripheral muscle dysfunction that influence in the low physical exercise tolerance. However, noninvasive ventilation is able to improve CHF functional capacity. Objective: Evaluated the efficiency of continuous positive airway pressure (CPAP) in physical exercise tolerance and heart rate variability (HRV) in the CHF patients. Material and Methods: seven man with CHF (62±8 years) and left ventricle eject fraction of 41±8% were submitted to symptom-limited incremental exercise test (IT) on the cicloergometer. At subsequent visit, on a separate days, these patients were randomized to performed four constant work rate exercise test without and with CPAP (5cmH2O) until maximal tolerance: i) at 50% peak work rate of IT; and ii) at 75% peak work rate of IT. At rest and during these tests, instantaneous heart rate (HR) was recorded using a cardiofrequencimeter and HRV was analyze by time domain (SDNN and RMSSD indexes). For statistical procedures, Wilcoxon test or Kruskall-Wallis test with Dunn post-hoc were used as appropriate. In additional, categorical variables were analysis through Fischer test (p
Abstract 5574: Cooperation of MT1-MMP and LOX-1 for RhoA- and Rac1-dependent Signaling Pathways in Oxidized LDL-mediated Endothelial Dysfunction and Atherosclerosis
Authors: Koichi Sugimoto, Toshiyuki Ishibashi, Tatsuya Sawamura, Hironori Uekita, Masashi Kamioka, Nobutaka Inoue, Masashi Shiomi, Yoh Takuwa, Tamio Teramoto, Yasuchika Takeishi
Journal: Circulation (2009)

Background: Membrane type 1-matrix metalloproteinase (MT1-MMP) functions not only as a proteolytic enzyme but also as a signaling molecule. Lectin-like oxidized-LDL receptor-1 (LOX-1) is a major receptor for oxidized LDL (ox-LDL). RhoA and Rac1 play crucial roles in endothelial dysfunction including eNOS downregulation and NADPH oxidase-dependent reactive oxygen species (ROS) generation. Hypothesis: MT1-MMP modifies ox-LDL-triggered RhoA- and Rac1-dependent endothelial dysfunction and atherosclerosis. Methods: GTP-loading of RhoA and Rac1 were assessed by pull-down assays. The activity of MT1-MMP was evaluated by fluorescent assay. A neutral antibody to LOX-1 (TS92) was used for inhibition of LOX-1, while MT1-MMP was silenced by siRNA. NADPH oxidase activity was determined by lucigenin-enhanced chemiluminescence. Fluorescent immunohistochemistry and immunoprecipitation were performed using the cultured endothelial cells (ECs) and the aortae of myocardial infarction-prone Watanabe heritable hyperlipidemic (WHHLMI) rabbits. Results: Ox-LDL activated RhoA and Rac1 within 5 and 15 minutes, as well as the MT1-MMP activity of membrane fractions after 15 minutes in ECs, which was inhibited by TS92. Ox-LDL-induced activation of RhoA and the downstream events including endothelial cell invasion and eNOS downregulation were blocked by silencing of MT1-MMP. Knockdown of MT1-MMP also markedly attenuated ox-LDL-triggered Rac1 activation, NADPH oxidase activity and ROS generation. Interestingly, LOX-1 and MT1-MMP were partly co-localized in ECs by fluorescent immunohistochemistry, and immunoprecipitation demonstrated that MT1-MMP formed a complex with LOX-1. Furthermore, immunohistochemistry revealed that the two molecules were co-localized in ECs and in the aortic atherosclerotic lesions of WHHLMI rabbits. In addition, immunoprecipitation demonstrated that MT1-MMP and LOX-1 formed a complex in cultured ECs and in the atherosclerotic aortae of WHHLMI rabbits. Conclusions: We show new insights into modulation of endothelial dysfunction and atherosclerosis by an MT1-MMP-LOX-1 axis, suggesting that MT1-MMP is a cell surface modifier of ox-LDL-triggered RhoA and Rac1-activated signaling pathways through LOX-1.
Corticosteroids improve airway epithelial regeneration and restore oxidative stress-induced epithelial barrier dysfunction
Authors: Irene Heijink, Maarten van den Berge, Nathalie Kliphuis, Nick ten Hacken, Dirkje Postma, Antoon van Oosterhout
Journal: European Respiratory Journal (2012)

Background: The airway epithelium plays an emerging role in the pathogenesis of respiratory diseases. Its barrier function may be defective in asthma and COPD. Aims: To study the protective effect of inhaled corticosteroid budesonide (BUD) on different aspects of epithelial integrity, including cell-cell contact formation, regeneration upon wounding and barrier function during mucociliary differentiation at the air-liquid interface (ALI). Methods: We studied the effect of BUD (10 -7 -10 -9 M) on epithelial resistance during ALI culture, upon exposure to H 2 O 2  and/or cigarette smoke extract (CSE) and upon wounding by electroporation using the ECIS system in 16HBE cells and primary human bronchial epithelial cells (PBECs) from asthma patients, COPD patients and healthy controls. Results: BUD significantly improved the recovery of cell-cell contacts upon wounding in 16HBE cells. Oxidative stress induced a transient defect in 16HBE barrier function, which was attenuated by BUD and likely mediated by the protection against EGFR-dependent disruption of junctions. In PBECs, CSE exposure resulted in a substantial barrier dysfunction, with no significant differences between the subject groups. BUD significantly improved baseline resistance and counteracted the CSE-induced barrier dysfunction. Finally, BUD slightly but significantly increased epithelial barrier function during ALI-culture, but did not affect MUC5A/C production. Conclusions: BUD improves the restoration of epithelial cell-cell contacts upon oxidative stress and wounding and may thus provide beneficial effects on epithelial barrier function, repair and remodelling in the airways of asthma and COPD patients.
Clinical characteristics, management, and outcomes of acute heart failure patients: observations from the Gulf acute heart failure registry (Gulf CARE)
Authors: Kadhim Sulaiman, Prashanth Panduranga, Ibrahim Al‐Zakwani, Alawi A. Alsheikh‐Ali, Khalid F. AlHabib, Jassim Al‐Suwaidi, Wael Al‐Mahmeed, Hussam AlFaleh, Abdelfatah Elasfar, Ahmed Al‐Motarreb, Mustafa Ridha, Bassam Bulbanat, Mohammed Al‐Jarallah, Nooshin Bazargani, Nidal Asaad, Haitham Amin
Journal: European Journal of Heart Failure (2015)
Chediak-Higashi syndrome: Lysosomal trafficking regulator domains regulate exocytosis of lytic granules but not cytokine secretion by natural killer cells
Authors: Aleksandra Gil-Krzewska, Stephanie M Wood, Yousuke Murakami, Victoria Nguyen, Samuel C C Chiang, Andrew R Cullinane, Giovanna Peruzzi, William A Gahl, John E Coligan, Wendy J Introne, Yenan T Bryceson, Konrad Krzewski
Journal: Journal of Allergy and Clinical Immunology (2015)
Patients with depressive symptoms presenting to the emergency department for asthma have worse clinical status
Authors: Carol A. Mancuso, Margaret G.E. Peterson, Jose L. Fernandez, Robert H. Birkhahn, Theodore J. Gaeta
Journal: European Respiratory Journal (2012)

Background: Depressive symptoms are associated with worse long-term asthma but less is known about their effects on acute exacerbations.  Methods: This analysis compared clinical characteristics according to depressive symptoms among 296 patients presenting for asthma to emergency departments (EDs) in New York City. At presentation patients completed valid surveys measuring asthma variables and depressive symptoms. Patients received follow-ups for 16 weeks.  Results: Mean age was 44 years, 72% were women, and 23% had a positive screen for depression. Compared to those with a negative screen, those with a positive screen were more likely not to know what triggered the exacerbation (11% vs 22%, p=.01), and to report worse asthma-related quality of life (p  Conclusions: Asthma ED patients with a positive screen for depression had worse self-report clinical status and more short-term resource utilization. Depressive symptoms may be modifiable and should be addressed in relation to acute exacerbations.
Captopril for Refractory Hypertension in Patients with Chronic Renal Failure and Renal Transplantation
Authors: D V Hamilton, D B Evans, G Maidment, J S Pryor
Journal: Journal of the Royal Society of Medicine (1981)

The converting-enzyme inhibitor, Captopril, was given to ten patients with refractory severe hypertension of renal origin: 6 patients had chronic renal failure, 3 patients had hypertension following renal transplantation, and one patient had hypertension and congestive cardiac failure. Control of blood pressure was achieved with doses from 75 to 400 mg/day. Severe hyperkalemia occurred in one patient, ageusia (dose dependent) in another, and one patient withdrew from treatment because of nausea.
Screening for cognitive deficits in 8 to 14-year old children with cerebellar tumors using self-report measures of executive and behavioral functioning and health-related quality of life
Authors: Kim S. Bull, Christina Liossi, Janet L. Peacock, Ho Ming Yuen, Colin R. Kennedy
Journal: Neuro-Oncology (2015)

We aimed to identify a brief screening measure for detection of cognitive deficit in children treated for cerebellar tumors that would be useful in clinical practice. A sample of 72 children, aged 8–14 years, and within 3 years post diagnosis for standard-risk medulloblastoma (n = 37) or low-grade cerebellar astrocytoma (n = 35) and 38 children in a nontumor group were assessed using teacher-, parent-, and child-report of the Behavior Rating Inventory of Executive Function (BRIEF), Strengths and Difficulties Questionnaire (SDQ), and Pediatric Quality of Life Inventory (PedsQL). The accuracy of these scores as a screen for a full-scale Intelligence Quotient (FSIQ) < 80 on the Wechsler Intelligence Scale for Children (WISC-IV UK) was assessed using their receiver operating characteristic (ROC) curves. The questionnaires with the highest areas under the ROC curves were the child- and parent-report PedsQL, the teacher-report BRIEF, and the SDQ. At optimal cutoff scores, their sensitivities (95% CIs) to cases of FSIQ < 80 were 84 (60–96)%, 65 (41–84)%, 79 (54–93)%, and 84 (60–96)%, and their specificities (95% CIs) were 79 (68–86)%, 87 (77–93)%, 77 (66–86)%, and 71 (64–84)% respectively. All cases of FSIQ < 80 screened positive on either teacher-report SDQ or self-report PedsQL. The PedsQL child- and parent-report and the teacher-report BRIEF and SDQ have moderately good accuracy for discriminating between children with and without a FSIQ < 80. The PedsQL could be used in a clinical setting, and the BRIEF and SDQ in an educational setting, to screen for cases with FSIQ < 80 in children treated for brain tumors.
Prognostic relevance of MYD88 mutations in CLL: the jury is still out
Authors: Panagiotis Baliakas, Anastasia Hadzidimitriou, Andreas Agathangelidis, Davide Rossi, Lesley-Ann Sutton, Jana Kminkova, Lydia Scarfo, Sarka Pospisilova, Gianluca Gaidano, Kostas Stamatopoulos, Paolo Ghia, Richard Rosenquist
Journal: Blood (2015)
Palliative Care, Version 1.2014
Authors: Michael H. Levy, Thomas Smith, Amy Alvarez-Perez, Anthony Back, Justin N. Baker, Susan Block, Shirley N. Codada, Shalini Dalal, Maria Dans, Jean S. Kutner, Elizabeth Kvale, Sumathi Misra, William Mitchell, Todd M. Sauer, David Spiegel, Linda Sutton, Robert M. Taylor, Jennifer Temel, Roma Tickoo, Susan G. Urba, Carin Van Zyl, Sharon M. Weinstein, Mary Anne Bergman, Jillian L. Scavone
Journal: Journal of the National Comprehensive Cancer Network (2014)

The NCCN Guidelines for Palliative Care provide interdisciplinary recommendations on palliative care for patients with cancer. These NCCN Guidelines Insights summarize the NCCN panel’s discussions and guideline updates from 2013 and 2014. These include modifications/additions to palliative care screening and assessment protocols, new considerations for discussing the benefits and risks of anticancer therapy, and approaches to advance care planning. Recent updates focus on enhanced patient-centered care and seek to promote earlier integration of palliative care and advance care planning in oncology.
A CHEST ROENTGEN-RAY STUDY OF THE ADULT NEGRO POPULATION OF AN ENTIRE COMMUNITY
Authors: D. O. N. Lindberg
Journal: Annals of Internal Medicine (1935)

Article1 May 1935A CHEST ROENTGEN-RAY STUDY OF THE ADULT NEGRO POPULATION OF AN ENTIRE COMMUNITYD. O. N. LINDBERG, M.D., F.A.C.P.D. O. N. LINDBERG, M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-8-11-1421 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptWith pulmonary tuberculosis in the United States reaching the point where many authorities predict its early relegation to the list of minor causes of death,1it has become essential to protect our present low mortality levels through the study and elimination of such reservoirs of infection as are recognized to be present among our heavily infected negro population. The literature clearly acknowledges that tuberculosis in the American negro with its high mortality rate is indeed an urgent problem.2For many reasons the control factors which have proved so successful among our white population have found little application among the negroes....Bibliography1. DUBLINVAN BUREN LIGH: Special aspects of declining tuberculosis deathrate in United States, Tubercle, 1927, ix, 22-31. CrossrefGoogle Scholar2. Tuberculosis Abstracts, 1933, vi, No. 6. Google Scholar3. GUILD CS: Tuberculosis among negroes; some of the problems that complicate its control, Jr. Am. Med. Assoc., 1933, ci, 2111-2113. CrossrefGoogle Scholar4. PINNERKASPER MJA: Pathological peculiarities of tuberculosis in American negro, Am. Rev. Tuberc., 1932, xxvi, 463-491. Google Scholar5. OPIE EL: The epidemiology of tuberculosis of negroes, Am. Rev. Tuberc., 1930, xxii, 603-612. Google Scholar6. CHADWICK HD: The negro and tuberculosis, Hospital Social Service, 1933, xxviii, 480. Google Scholar7. CHADWICK HD: The negro and tuberculosis, Hospital Social Service, 1933, xxviii, 481. Google Scholar8. RIGLER L: Value of x-ray examination in pulmonary tuberculosis, Minn. Med., 1930, xiii, 25-27. Google Scholar9. ELLMAN P: Chest disease in general practice, 1932, H. K. Lewis and Co., London, page 35. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Decatur, Illinois*Read before Mississippi Valley Sanatorium Association, September 28, 1934, Cedar Rapids, Iowa. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 May 1935Volume 8, Issue 11Page: 1421-1426KeywordsAdultsDeath ratesMortalityPulmonary diseasesThoraxTuberculosis ePublished: 1 December 2008 Issue Published: 1 May 1935 PDF downloadLoading ...
Malaria and tourism: retrospective analysis of German malaria cases imported from the Dominican Republic
Authors: J Richter, A Sagir, A. Schöneberg, K Alpers, D Häussinger
Journal: Eurosurveillance (2001)

We report on malaria acquired by German tourists to formerly non-endemic tourist resorts in the Dominican Republic between July 1999 and March 2000. Falciparum malaria is endemic in the western provinces and the hinterland of the Dominican Republic. By contrast, the risk of contracting malaria has always been considered so low in the main tourist resorts in the eastern part of the country that antimalarial chemoprophylaxis was not recommended.
Evidence for physical and psychological dependence on anabolic androgenic steroids in eight weight lifters
Authors: Kirk J. Brower, George A. Eliopulos, Frederic C. Blow, Donald H. Catlin, Thomas P. Beresford
Journal: American Journal of Psychiatry (1990)

All eight users of anabolic androgenic steroids in a pilot survey of weight lifters reported withdrawal symptoms and continued steroid use despite adverse consequences. Psychiatric (especially, depressive) symptoms were prominent in dependent users, underscoring the importance of diagnosing steroid dependence in clinical practice.
Preoperative chemotherapy (CTX) versus preoperative chemoradiotherapy (CRTX) in locally advanced esophagogastric adenocarcinomas: First results of a randomized phase III trial
Authors: M. Stahl, M. K. Walz, M. Stuschke, N. Lehmann, M. H. Seegenschmiedt, J. Riera Knorrenschild, P. Langer, M. Bieker, A. Königsrainer, W. Budach, H. Wilke
Journal: Journal of Clinical Oncology (2007)

4511 Background: Perioperative treatment is common in localized adenocarcinomas of the upper GI-tract. By now, there is no randomized data about the contribution of preoperative radiotherapy additional to chemotherapy. Methods: Based on phase II results of our group we targeted 394 patients to test whether chemoradiation will increase the 3-year survival rate by 10% compared with chemotherapy. Patients with stage T3–4 NX M0 according to EGD, EUS, CT and laparoscopy were included. Patients were randomized to treatment with either (arm A) 2.5 courses of chemotherapy (cisplatin 50mg/m 2 , d 1,15,29, folinic acid 500 mg/m 2 and 5-FU 2g/m 2 24h-infusion, weekly times 6, qd 49 or (arm B) 2 courses of the same chemotherapy followed by three weeks of chemoradiotherapy (30 Gy, cisplatin 50 mg/m 2 d 2+8 and etoposide 80 mg/m 2 d 3–5). Epoetin alpha was recommended to keep the hemoglobin above 12.5 g/dl. Tumor resection was planned 3 to 4 weeks after the end of preoperative therapy for both groups. Results: A total of 126 patients were randomized into the study between 12/00 and 12/05 when the trial was closed due to poor accrual. 120 pts. were eligible (CTX 60, CRTX 60). The toxicitiy of CTX was low. Severe leucocytopenia and thrombocytopenia was 35% and 16%, respectively during CRTX. Until 12/06 ninety pts. underwent surgery and had complete reports. A complete resection was possible in 77% and 85% of operated pts. in arm A and arm B, respectively. The rate of complete histologic response was 2.5% after CTX and it reached 17% after CRTX (p=0.06). Despite increased postoperative mortality after chemoradiotherapy (5 vs. 2 pts.) the median survival time (32.8 mo) and the 3- year survival rate (43%) were improved in this patients group compared with patients of arm A (21.1 mo, 27%)(logrank p=0.14). Conclusions: This randomized study demonstrates that albeit its increased mortality preoperative chemoradiotherapy appears to prolong survival compared with preoperative chemotherapy in locally advanved esophago-gastric adenocarcinomas. Although accrual was below that planned, the observed difference in survival is clinically important and calls for further randomized trials in patients with this disease. No significant financial relationships to disclose.
Abstract 18982: Percutaneous Coronary Intervention (PCI) is Equivalent to Coronary Artery Bypass Grafting (CABG) for Unprotected Left Main Coronary Artery Disease: 5 year Follow-up Analysis
Authors: Tarun Chakravarty, Ryan P Morrissey, Anthony J White, Niraj Doctor, Gregory Fontana, Alfredo Trento, Suhail Dohad, James M Mirocha, James S Forrester, Raj Makkar
Journal: Circulation (2010)

Background: The 2009 ACC/AHA updated guidelines modified the recommendation for percutaneous coronary intervention (PCI) of unprotected left main coronary artery (ULMCA) from Class III to Class IIb...