tbuckley/cabot-search huggingface dataset:
Abstract 11247: The Long Noncoding MALAT1 - MascRNA System is a Novel Regulator of Cardiac Innate Immunity
Authors: Wolfgang Poller, Martina Gast, Blanche Schroen, Antje Voigt, Jan Haas, Anna Papageorgiou, Uwe Kuehl, Dirk Lassner, Xiaomin Wang, Madlen Loebel, Sabrina Wilk, Nadine Althof, Tim Peters, Kannanganattu Prasanth, Hugo Katus, Benjamin Meder, Shinichi Nakagawa, Carmen Scheibenbogen, Stephane Heymans
Journal: Circulation (2014)

Background: Regarding disease pathogenesis, it has become evident that confinement to analysis of protein-coding regions of the genome is insufficient since many noncoding regions are associated with human diseases. We searched for elements of the noncoding genome influencing the highly variable course of a cardiomyopathy caused by a common single-stranded RNA virus (CVB3). Methods and Results: Transcriptome mapping of human CVB3 cardiomyopathy hearts showed high long noncoding RNAs (lncRNA) MALAT1 associated with spontaneous virus clearance and recovery, and low MALAT1 with virus persistence and clinical deterioration. Primary [[Unable to Display Character: ]]7kb MALAT1 transcript is only part of a complex RNA processing system generating e.g. mascRNA, a tRNA-like molecule, by a novel biosynthetic pathway. First, we found cell type-specific MALAT1 processing to result in grossly different mascRNA levels, which were highest in leukocytes. Second, CVB3 infection of genetically MALAT1-deficient (MAL...
Abstract 577: Genetic and epigenetic alterations of the WWOX gene in head and neck cancer
Authors: NUR BUYRU, Seda Ekizoglu, Hikmet Koseoglu, Emin Karaman
Journal: Cancer Research (2014)

Abstract Head and neck squamous cell carcinoma (HNSCC) is a heterogenous disease and the 6th most frequent cancer in the world. Despite advances in medical treatment over the past two decades, the overall survival rate for patients with HNSCC remains around 50%. Well known environmental risk factors for developing HNSCC are cigarette smoking, especially in combination with alcohol consumption or tobacco chewing. In addition, many genetic and epigenetic changes are associated with sporadic HNSCC including alterations in the p53, VEGF and cyclin D1genes. Yet the molecular mechanisms of HNSCC carcinogenesis are still undergoing intensive investigation. The WWOX gene is located on a chromosomal fragile site 16q23.2 which spans the common fragile site FRA16D. It has been shown that exposure to environmental carcinogens such as smoking and alcohol consumption increases the potential for chromosomal breakage at the FRA16D site in esophageal and non-small cell lung cancers. On the other hand, genomic abnormalities affecting chromosome 16q are frequently reported in cytogenetic studies of various epithelial tumors, including prostate, breast, ovarian, esophageal, lung, gastric, and hepatocellular carcinomas. However, there is no data in the literature investigating the WWOX gene in the HNSCC. Therefore, the aim of this study was to determine the role of WWOX as a tumor suppressor gene in patients with HNSCC. For this purpose, tumor and corresponding normal tissue samples obtained from 75 patients with HNSCC were analyzed for mutations in the coding exons and the flanking intronic sequences by direct sequencing of the WWOX gene. mRNA expression levels were also analyzed by quantitative-real time-PCR and correlated with the methylation level of the WWOX gene promoter. The methylation status was determined by methylation-specific PCR(MSP). mRNA expression levels were significantly lower in tumor tissue than normal tissue (p≤0.001) and this downregulation was associated with hypermethylation of the promoter of the WWOX gene (p≤0.05). We identified 8 different alterations in the coding sequence of the WWOX gene with a frequency varying between 1.56-58.93%. Additionally, 17 different alterations in the noncoding regions were identified in our study group. Our results indicate that the WWOX gene may play an important role in the development of HNSCC. Citation Format: NUR BUYRU, Seda Ekizoglu, Hikmet Koseoglu, Emin Karaman. Genetic and epigenetic alterations of the WWOX gene in head and neck cancer. [abstract]. In: Proceedings of the 105th Annual Meeting of the American Association for Cancer Research; 2014 Apr 5-9; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2014;74(19 Suppl):Abstract nr 577. doi:10.1158/1538-7445.AM2014-577
Recognition and Evaluation of Lapachol as an Antitumor Agent
Authors: K. V. Rao, T. J. McBride, J. J. Oleson
Journal: Cancer Research (1968)

Summary  The extracts of  Stereospermum suaveolens  showed reproducible activity against the Walker 256 intramuscular tumor system. The active principle was isolated and shown to be identical with the known compound lapachol, 2-hydroxy-3-(3-methyl-2-butenyl)-1,4-naphthoquinone. Lapachol shows highly significant activity against Walker 256 carcinosarcoma when given by intraperitoneal, subcutaneous, intramuscular, and oral routes. The best activity and therapeutic index are shown when the drug is given twice daily by the oral route.
Preventing recurrent coronary heart disease
Authors: T. van der Weijden, R. Grol
Journal: BMJ (1998)

General practice pp 1430, 1434 

Following the publication of several recent large studies (4S, CARE, and WOSCOPS), there is little doubt about the importance of prevention in patients with coronary heart disease, though controversy still exists about its value in patients without symptoms. General practitioners are in a favourable position to take on the task of secondary prevention, since most have a continuing relationship with their patients, and these patient contacts offer opportunities for measuring cardiovascular risk factors. Nevertheless, preventive care in general practice is haphazard, 1 2 and in this issue Campbell et al confirm this shortfall (p 1430).3 The question that therefore arises is how to implement the new evidence on preventing coronary heart disease effectively in general practice.

An audit in 95 practices in the Netherlands showed that many general practitioners had a critical attitude towards integrating prevention into practice4 and that few practices were sufficiently well organised to provide effective …
Abstract 178: The Early Resuscitation Protein PBEF Is Released from Human Neutrophils via an Unconventional Pathway
Authors: Xiangdong Zhu, Angelo Meliton, Jing Li, Andrew Bellino, Mengqi Zhu, Huashan Wang, Alan R Leff, Terry L Vanden Hoek
Journal: Circulation (2014)

Introduction: Our previous work suggests that PBEF, encoded by the NAMPT gene, is an early blood marker inversely related to hypothermia protection and resuscitation survival in a mouse model of hemorrhagic shock. Higher mouse blood PBEF concentrations were related to acute inflammation and cardiovascular collapse. More recently, clinical work by others demonstrated a correlation between high PBEF blood concentrations and acute heart failure exacerbation. Given that neutrophils are a potential high-concentration source of blood PBEF, we studied mechanisms of release from isolated human neutrophils that could help design novel resuscitation strategies.

Methods: Human blood neutrophils were isolated by Percoll density gradient. PBEF secretion into neutrophil supernatant was measured by ELISA. Neutrophil PBEF protein expression was measured by Western blot analysis.

Results: PBEF in unstimulated neutrophil supernatant was observed at 5 min and plateaued after 30 min at 37oC (8.6 ± 0.7 vs. 0.9 ± 0.3 ng/ml, p < 0.01). This release was not due to cell injury since LDH was unchanged, nor was it blocked by the classical secretion inhibitors, brefeldin A (blocks ER-Golgi transport) or nocodazole (blocks microtubule polymerization). However, PBEF secretion was attenuated by decreased temperature (4oC), suggesting a release mechanism other than passive diffusion. Indeed, glyburide an inhibitor of the ATP-binding cassette 1 (ABC 1) transporter reduced PBEF secretion by 55%. The calcium chelator EGTA completely blocked PBEF secretion. PBEF release was also dose-dependently blocked by extracellular ATP. Exogenous ATP induced the degradation of intracellular PBEF, which was blocked by pretreatment with a proteasomal inhibitor MG132, suggesting intracellular PBEF stability also regulates its secretion.

Conclusions: PBEF is constitutively released from neutrophils via an unconventional secretion pathway. Its release is regulated by the ABC1 membrane transporter, calcium, and intracellular proteasome degradation. Changes in human neutrophil microenvironment result in significant change of PBEF release within a timeframe that could account for the blood changes seen during mouse cardiovascular resuscitation.
EXPERT WITNESSES APPOINTED BY THE COURT.
Authors: Joseph F. Franzoi
Journal: JAMA (1904)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Bariatric Surgery for Morbid Obesity—Reply
Authors: P. Barton Duell
Journal: JAMA (2003)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Detection of viruses in myocardial tissues by polymerase chain reaction
Authors: Neil E Bowles, Jiyuan Ni, Debra L Kearney, Matthias Pauschinger, Heinz-Peter Schultheiss, Robert McCarthy, Joshua Hare, J.Timothy Bricker, Karla R Bowles, Jeffrey A Towbin
Journal: Journal of the American College of Cardiology (2003)
Abstract 2554: DDX3X-specific effector T cells in small cell lung cancer patients reflect disease stage
Authors: Natsue Igarashi, Hiroshi Kagamu, Koichiro Nozaki, Satoshi Shoji, Masaaki Okajima, Satoru Miura, Satoshi Watanabe, Hirohisa Yoshizawa, Ichiei Narita
Journal: Cancer Research (2014)

Abstract [Background] Small cell lung cancer (SCLC) possesses high tendency to disseminate. However, SCLC patients with paraneoplastic syndrome mediated by immunity against onconeural antigens remain in limited-stage disease (LD) without distant metastases. We previously demonstrated that effector-dominant CD4+ T cell balance was observed only in LD-SCLC but not in extended-stage disease (ED)-SCLC. CD4+ T cell balance in peripheral blood of SCLC patients reflected disease stage and recurrence. Accumulating evidence suggests that most solid malignancies consist of heterogeneous tumor cells and that a relatively small subpopulation, which shares biological features with stem cells, is responsible for distant metastases and recurrence. We previously reported that DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 3, X-linked (DDX3X) is an immunogenic protein preferentially expressed in CD133+ murine melanoma cells exhibiting biological CSC features and that DDX3X-primed CD4+ T cells mediated potent antitumor therapeutic efficacy. We found that DDX3X is strongly expressed in small cell lung cancer (SCLC). [Objectives] In the current study, we examine that DDX3X-specific effector T cells exist in SCLC patients. [Patients and Methods] The present study comprised 20 consecutive SCLC patients, 5 long-term survivors, and 10 healthy volunteers from a single institution (Niigata University Medical and Dental Hospital). Specimens were collected after obtaining written informed consent approved by the Niigata University Ethical Committee. [Results] Six of 12 LD-SCLC patients possessed DDX3X-responsive effector T cells. CD62Llow CD4+ effector T cells obtained from peripheral blood of 5 LD-SCLC secreted significantly more IFNγ upon DDX3X antigen stimulation in the presence of CD11c+ autologous dendritic cells. CD62Llow CD8+ effector T cells from one LD-SCLC patient responded to DDX3X. In contrast, effector T cells obtained from ED-SCLC patients or healthy volunteers never responded to DDX3X. [Conclusion] DDX3X is likely one of major antigens that is expressed in SCLC and is recognized by T cell immune system. Antitumor immunotherapy to induce effector-dominant CD4+ T-cell immunity on DDX3X antigen may be a promising therapy to eliminate SCLC cells that mediate distant metastases. Citation Format: Natsue Igarashi, Hiroshi Kagamu, Koichiro Nozaki, Satoshi Shoji, Masaaki Okajima, Satoru Miura, Satoshi Watanabe, Hirohisa Yoshizawa, Ichiei Narita. DDX3X-specific effector T cells in small cell lung cancer patients reflect disease stage. [abstract]. In: Proceedings of the 105th Annual Meeting of the American Association for Cancer Research; 2014 Apr 5-9; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2014;74(19 Suppl):Abstract nr 2554. doi:10.1158/1538-7445.AM2014-2554
Excess of rare, inherited truncating mutations in autism
Authors: Niklas Krumm, Tychele N Turner, Carl Baker, Laura Vives, Kiana Mohajeri, Kali Witherspoon, Archana Raja, Bradley P Coe, Holly A Stessman, Zong-Xiao He, Suzanne M Leal, Raphael Bernier, Evan E Eichler
Journal: Nature Genetics (2015)
The Scientific Basis of Evolution.
Authors: Thomas Hunt Morgan
Journal: JAMA (1933)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Aromatic hydrocarbon receptor-driven Bax gene expression is required for premature ovarian failure caused by biohazardous environmental chemicals
Authors: Tiina Matikainen, Gloria I. Perez, Andrea Jurisicova, James K. Pru, Jennifer J. Schlezinger, Heui-Young Ryu, Jarmo Laine, Toshiyuki Sakai, Stanley J. Korsmeyer, Robert F. Casper, David H. Sherr, Jonathan L. Tilly
Journal: Nature Genetics (2001)
Abstract 2722: Suppression of breast cancer cell migration by novel inhibitors that target transient receptor potential-melastatin-like 7 (Trpm7) kinase activity
Authors: Tamer Saad Kaoud, Jihyun Park, Clint D.J. Tavares, Shreya Mitra, Micael Cano, Chun-Chia Tseng, Kevin N. Dalby
Journal: Cancer Research (2014)

Abstract TRPM7 (transient receptor potential melastatin 7) encodes a calcium permeable non-selective cation channel implicated in cell adhesion and magnesium homoeostasis. The TRPM7 gene encodes for a protein kinase whose activity is linked to the control of actomyosin contractility. TRPM7 mediates adhesion and migration of MDA-MB-231 breast cancer cells and recently has been reported to promote breast tumor cell metastasis. The lack of cell-permeable pharmacological inhibitors of the kinase domain represents a barrier to fully understanding kinase function. Herein, we describe the discovery of several compounds that target TRPM7 kinase activity and which were shown to decrease the binding of Myosin IIB to TRPM7 in HEK293 cells and MDA-MB-231 breast cancer cells transfected with pCMV6-TRPM7. Interestingly, two of the inhibitors potentially inhibited MDA-MB-231 breast cancer cells migration that have been reported to be regulated by TRPM7 kinase activity. Finally, magnesium starvation, which promotes TRPM7 kinase activity, induces phosphorylation of eEF2. Treatment of cells with several of the compounds decreased eEF2 phosphorylation under conditions of magnesium starvation, consistent with the notion that they inhibit TRPM7 kinase activity in cells. Citation Format: Tamer Saad Kaoud, Jihyun Park, Clint D.J. Tavares, Shreya Mitra, Micael Cano, Chun-Chia Tseng, Kevin N. Dalby. Suppression of breast cancer cell migration by novel inhibitors that target transient receptor potential-melastatin-like 7 (Trpm7) kinase activity. [abstract]. In: Proceedings of the 105th Annual Meeting of the American Association for Cancer Research; 2014 Apr 5-9; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2014;74(19 Suppl):Abstract nr 2722. doi:10.1158/1538-7445.AM2014-2722
Endoscopic snare papillectomy: a possible radical treatment for a subgroup of T1 ampullary adenocarcinomas
Authors: G. Petrone, R. Ricci, P. Familiari, F. Inzani, M. Matsuoka, M. Mutignani, G. Delle Fave, G. Costamagna, G. Rindi
Journal: Endoscopy (2013)

Pancreaticoduodenectomy is the standard care for invasive ampullary adenocarcinomas. However, endoscopic snare papillectomy (ESP) might play a curative role in very selected patients. We studied a series of 15 patients with T1 ampullary adenocarcinoma who were treated by ESP alone and followed up for a mean of 29.6 ± 21.9 months (range 8 - 81 months). ESP was curative for eight patients (57.1 %). No tumor-related death was observed in patients with a cancer infiltration depth of ≤ 4 mm. According to this preliminary experience, we suggest that this measurable variable threshold should be considered as a possible basis for future large-scale studies.
Acquired EGFR C797S mutation mediates resistance to AZD9291 in non–small cell lung cancer harboring EGFR T790M
Authors: Kenneth S Thress, Cloud P Paweletz, Enriqueta Felip, Byoung Chul Cho, Daniel Stetson, Brian Dougherty, Zhongwu Lai, Aleksandra Markovets, Ana Vivancos, Yanan Kuang, Dalia Ercan, Sarah E Matthews, Mireille Cantarini, J Carl Barrett, Pasi A Jänne, Geoffrey R Oxnard
Journal: Nature Medicine (2015)
American Board of Internal Medicine and Maintenance of Certification Standards—Reply
Authors: Eric S. Holmboe, David A. Cook
Journal: JAMA Internal Medicine (2015)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Internal Medicine HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Internal Medicine journal
Noninvasive Differential Diagnosis Between Chronic Pulmonary Thromboembolism and Primary Pulmonary Hypertension by Means of Doppler Ultrasound Measurement
Authors: Yasunori Nakayama, Masaru Sugimachi, Norifumi Nakanishi, Hiroshi Takaki, Yoshiaki Okano, Toru Satoh, Kunio Miyatake, Kenji Sunagawa
Journal: Journal of the American College of Cardiology (1998)
Expanded Newborn Genetic Testing Urged
Authors: Tracy Hampton
Journal: JAMA (2004)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
A patient who changed my practice: It is too easy to blame only the patient
Authors: R J Daniels
Journal: BMJ (2001)

As a trainee general practitioner in ophthalmology, I spent every Monday morning in the diabetes clinic. After five years in hospital medicine I had come to associate a fat stack of notes in young people with poorly controlled diabetes and the inevitable “you must do better or you will go blind/get renal failure/get angina/have a stroke” advice falling on deaf ears. I always felt that, no matter how I explained things, these sorts of patients either didn't understand, didn't believe me, or just …
The Changing Landscape of Whole-Brain Radiation Therapy
Authors: Kevin S. Oh, Jay S. Loeffler
Journal: JAMA Oncology (2015)

Hidefumi Aoyama, MD, PhD; Masao Tago, MD, PhD; Hiroki Shirato, MD, PhD; for the Japanese Radiation Oncology Study Group 99-1 (JROSG 99-1) Investigators