tbuckley/cabot-search huggingface dataset:
Roles of the Ras/Raf/MEK/ERK pathway in leukemia therapy
Authors: L S Steelman, R A Franklin, S L Abrams, W Chappell, C R Kempf, J Bäsecke, F Stivala, M Donia, P Fagone, F Nicoletti, M Libra, P Ruvolo, V Ruvolo, C Evangelisti, A M Martelli, J A McCubrey
Journal: Leukemia (2011)
Diabetes care in general practice: meta-analysis of randomised control trials Commentary: Meta-analysis is a blunt and potentially misleading instrument for analysing models of service delivery
Authors: S. Griffin, T. Greenhalgh
Journal: BMJ (1998)

<h3>Abstract</h3> <b>Objective</b> : To assess the effectiveness of care in general practice for people with diabetes. <b>Design</b> : Meta-analysis of randomised trials comparing general practice and shared care with follow up in hospital outpatient clinic. <b>Identification</b> : Trials were identified from searches of eight bibliographic and research databases. <b>Results</b> : Five trials identified included 1058 people with diabetes, overall mean age 58.4 years, receiving hospital outpatient follow up for their diabetes. Results were heterogeneous between trials. In shared care schemes featuring more intensive support through a computerised prompting system for general practitioners and patients, there was no difference in mortality between care in hospital and care in general practice (odds ratio 1.06, 95% confidence interval 0.53 to 2.11); glycated haemoglobin tended to be lower in primary care (weighted difference in means of 0.28%, 0.59% to 0.03%); and losses to follow up were significantly lower in primary care (odds ratio 0.37, 0.22 to 0.61). However, schemes with less well developed support for family doctors were associated with adverse outcomes for patients. <b>Conclusions</b> : Unstructured care in the community is associated with poorer follow up, worse glycaemic control, and greater mortality than in hospital care. Computerised central recall, with prompting for patients and their family doctors, can achieve standards of care as good as or better than hospital outpatient care, at least in the short term. The evidence supports provision of regular prompted recall and review of selected people with diabetes by willing general practitioners. This can be achieved if suitable organisation is in place.
Personalized Medicine: Personalizing Biomaterials for Precision Nanomedicine Considering the Local Tissue Microenvironment (Adv. Healthcare Mater. 11/2015)
Authors: Nuria Oliva, Shimon Unterman, Yi Zhang, João Conde, Hyun Seok Song, Natalie Artzi
Journal: Advanced Healthcare Materials (2015)

The complex and dynamic tissue microenvironment requires therapeutic biomaterials to be built from versatile building blocks that can meet variations in physiology that are further altered local pathology, to enhance the clinical outcomes. On page 1584 N. Artzi and team show how advances in material design and characterization techniques now allow substantially more sophisticated tuning of biomaterial properties to include exciting multi-functionalities including sensing, targeting, and delivery. (Cover design: Joao Conde.)
Effect of Inhaled Nitric Oxide on Normal Human Left Ventricular Function fn1fn1Dr. Hayward is a recipient of a Postgraduate Medical Research Scholarship from the National Health and Medical Research Council of Australia, Canberra, Australia. This work was supported by a Research Project Grant to Dr. Kelly from the National Heart Foundation of Australia, Canberra, Australia.
Authors: Christopher S. Hayward, Wally V. Kalnins, Peter Rogers, Michael P. Feneley, Peter S. Macdonald, Raymond P. Kelly
Journal: Journal of the American College of Cardiology (1997)
Baseline characteristics and treatment of patients in Prospective comparison of <scp>ARNI</scp> with <scp>ACEI</scp> to Determine Impact on Global Mortality and morbidity in Heart Failure trial (<scp>PARADIGM‐HF</scp>)
Authors: John J. V. McMurray, Milton Packer, Akshay S Desai, Jianjian Gong, Martin Lefkowitz, Adel R. Rizkala, Jean L. Rouleau, Victor C. Shi, Scott D. Solomon, Karl Swedberg, Michael R. Zile
Journal: European Journal of Heart Failure (2014)

To describe the baseline characteristics and treatment of the patients randomized in the PARADIGM-HF (Prospective comparison of ARNi with ACEi to Determine Impact on Global Mortality and morbidity in Heart Failure) trial, testing the hypothesis that the strategy of simultaneously blocking the renin-angiotensin-aldosterone system and augmenting natriuretic peptides with LCZ696 200 mg b.i.d. is superior to enalapril 10 mg b.i.d. in reducing mortality and morbidity in patients with heart failure and reduced ejection fraction.
S6K1 controls pancreatic β cell size independently of intrauterine growth restriction
Authors: Sung Hee Um, Melanie Sticker-Jantscheff, Gia Cac Chau, Kristina Vintersten, Matthias Mueller, Yann-Gael Gangloff, Ralf H. Adams, Jean-Francois Spetz, Lynda Elghazi, Paul T. Pfluger, Mario Pende, Ernesto Bernal-Mizrachi, Albert Tauler, Matthias H. Tschöp, George Thomas, Sara C. Kozma
Journal: Journal of Clinical Investigation (2015)

Type 2 diabetes mellitus (T2DM) is a worldwide heath problem that is characterized by insulin resistance and the eventual loss of β cell function. As recent studies have shown that loss of ribosomal protein (RP) S6 kinase 1 (S6K1) increases systemic insulin sensitivity, S6K1 inhibitors are being pursued as potential agents for improving insulin resistance. Here we found that S6K1 deficiency in mice also leads to decreased β cell growth, intrauterine growth restriction (IUGR), and impaired placental development. IUGR is a common complication of human pregnancy that limits the supply of oxygen and nutrients to the developing fetus, leading to diminished embryonic β cell growth and the onset of T2DM later in life. However, restoration of placental development and the rescue of IUGR by tetraploid embryo complementation did not restore β cell size or insulin levels in S6K1-/- embryos, suggesting that loss of S6K1 leads to an intrinsic β cell lesion. Consistent with this hypothesis, reexpression of S6K1 in β cells of S6K1-/- mice restored embryonic β cell size, insulin levels, glucose tolerance, and RPS6 phosphorylation, without rescuing IUGR. Together, these data suggest that a nutrient-mediated reduction in intrinsic β cell S6K1 signaling, rather than IUGR, during fetal development may underlie reduced β cell growth and eventual development of T2DM later in life.
Risk of serious infection in biological treatment of patients with rheumatoid arthritis: a systematic review and meta-analysis
Authors: Jasvinder A Singh, Chris Cameron, Shahrzad Noorbaloochi, Tyler Cullis, Matthew Tucker, Robin Christensen, Elizabeth Tanjong Ghogomu, Doug Coyle, Tammy Clifford, Peter Tugwell, George A Wells
Journal: The Lancet (2015)
Abstract P432: Effects of Weight Management by Exercise Mode on Subclinical Atherosclerosis for Women with Abdominal Obesity: A Randomized Controlled Trial
Authors: Jina Choo, Juneyoung Lee, Akira Sekikawa, Lora E Burke, Sae-Young Jae
Journal: Circulation (2014)

Purpose: Few studies have examined differential effects of weight management by exercise mode on subclinical atherosclerosis. We hypothesized that exercise modes of aerobic, resistance, and combination exercises would have differential effects on endothelial dysfunction, aortic stiffness, and carotid intima-media thickness (IMT) in a weight management intervention. Methods: We conducted a randomized controlled trial in which 110 sedentary women with abdominal obesity were enrolled in a 12-month weight management program between September 2010 and November 2011. Fifty participants were randomly assigned to an aerobic training group, 30 to a resistance training group, and 30 to a combined aerobic and resistance training group. The weight management had a diet-alone intervention for the first 3 months and a diet-plus-exercise intervention for the next 9 months according to exercise modes. Exercise training was designed for three days per week in 60-minute sessions and a gradual increase in exercise intensity using % heart rate reserve. Flow-mediated dilation (FMD), carotid-femoral pulse wave velocity (PWV), and carotid IMT were measured at 0, 3, 6, 9, and 12 months. Results: Participants had a mean age of 43.1 years and a mean body mass index of 28.5 kg/m 2 . After a 12-month intervention, participants experienced a weight loss of approximately 5%. Changes in FMD, PWV, and IMT did not differ significantly by exercise mode, but PWV and IMT were significantly reduced over the diet-plus-exercise intervention. Conclusion: Among women with abdominal obesity, the effects of weight management on subclinical atherosclerosis did not differ by exercise mode, but its effects on aortic stiffness and carotid IMT may be beneficial over time.
Collective Consciousness and Its Discontents: Institutional Distributed Cognition, Racial Policy and Public Health in the United States
Authors: Mindy T. Fullilove, Rodrick Wallace
Journal: JAMA (2008)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Journals JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Effect of Deferasirox (Exjade®) on Labile Plasma Iron Levels in Heavily Iron-Overloaded Patients with Transfusion-Dependent Anemias Enrolled in the Large-Scale, Prospective 1-Year EPIC Trial
Authors: John B Porter, Maria Domenica Cappellini, Amal El-Beshlawy, Antonis Kattamis, John F Seymour, Jong Wook Lee, Hanspeter Nick, Dany Habr, Gabor Domokos, Abdel Hmissi, Ali Taher
Journal: Blood (2008)
I Will Leave You One Day
Authors: Mark Isaacson
Journal: JAMA (2005)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
How the Atlantic barons learnt teamwork
Authors: D. Johnson
Journal: BMJ (2001)

See pp 501, 517, 548, 562 

Bored and having been awake through jet lag from 3 am, I turned on the TV in my hotel room in Denver. I had arrived the day before and would that day leave for London: a routine trip for an airline pilot. A rather handsome man appeared on the screen. It was David Lawrence, chairman of Kaiser Permanente Medical Group, the largest non-profit healthcare organisation in the US, but he was speaking about aircraft crashes. He stated that in the United States from 1950 to 1990 commercial aviation fatalities fell from 1.19 to 0.27 per million departures—an 80% reduction in the face of a dramatic increase in the volume of air traffic. I forgot about breakfast and watched the speech.

> The experience of aviation shows that we can help the NHS understand safety problems 

Dr Lawrence made six points about standard aviation safety practice. These included statutory reporting procedures, a voluntary (without jeopardy) reporting culture, recurring statutory examinations, systems, …
Sequential changes in hematologic and biochemical parameters in African tick bite fever
Authors: M. Jensenius, P.-E. Fournier, K.B. Helium, L. Wesslén, G. Caruso, T. Priø, K. Løhne, S. Vene, D. Raoult, B. Myrvang
Journal: Clinical Microbiology and Infection (2003)
Squamous cell carcinoma complicating chronic venous leg ulceration: a study of the histopathology, course and survival in 25 patients
Authors: None Baldursson, None Hedblad, None Beitner, None Lindelöf
Journal: British Journal of Dermatology (1999)

We have studied 25 cases of squamous cell carcinoma in chronic venous leg ulcers. Twenty-three of the patients were dead and two were alive. The mean age at cancer diagnosis was 78.5 years. The median survival was 1 year. Eleven tumours were well-differentiated, 10 moderately and four poorly. All patients with a poorly differentiated tumour died within a year. Metastases were certain in eight cases. The disease was lethal in 10 cases which included all poorly differentiated tumours. The survival of the study group was significantly shortened compared with a control group of patients with lower limb non-melanoma skin cancer (n = 433) from the Swedish Cancer Registry (P = 0.0084). When diagnosed, squamous cell carcinoma in chronic leg ulcers merits a thorough investigation of the degree of differentiation and spread. Assertive treatment is indicated as poorly differentiated tumours and some moderately differentiated tumours may be fatal.
Preservation of tumor-host immune interactions with luciferase-tagged imaging in a murine model of ovarian cancer
Authors: John B Liao, Kelsie J Ovenell, Erin E M Curtis, Denise L Cecil, Marlese R Koehnlein, Lauren R Rastetter, Ekram A Gad, Mary L Disis
Journal: Journal for ImmunoTherapy of Cancer (2015)

Ovarian cancer is immunogenic and residual tumor volume after surgery is known to be prognostic. Ovarian cancer often follows a recurring-remitting course and microscopic disease states may present ideal opportunities for immune therapies. We sought to establish the immune profile of a murine model of ovarian cancer that allows in vivo tumor imaging and the quantitation of microscopic disease.
Aeroallergens and viable microbes in sandstorm dust
Authors: A. A. A. Kwaasi, V. R. S. Parhar, F. A. A. Al‐Mohanna, H. A. Harfi, K. S. Collison, S. T. Al‐Sedairy
Journal: Allergy (1998)

Aeroallergens and antigens in sandstorm dust, extracts of which were skin prick test (SPT) positive in allergic patients, were detected by roeket immunoelectrophoresis and ELISA. Fungi and bacteria isolated by agar settle plates and soil dilution and soil washing methods were enumerated and identified. Cat dander. Acacia, Alternaria. Aspergillus. Chenopodium. Ciadosporium, Bermuda grass, Pitheceilobiiim, Prosopis. Rumex, cultivated rye. and Washingtonia palm allergens were detected by both methods. Viable microbes including 1892±325 eolony‐forming units (cfu) of bacteria, and 869±75 cfu of fungi were isolated per gram of dust by the soil dilution method. Randomly selected microbial colonies on streaking and subculture were found to consist of between two and seven mixed colonies. Fungi including Alternaria, Aspergiiius, Botrytis, Ciadosporium, Mortierelia, Mucor, Mycelia sterilia, Peniciilium, Pythium, Uiodadium, Verticiliium, and some yeasts were isolated. Actinomyces, Bacillus, Pseudomonas. and mostly coagulase‐negative Staphylococcus species were identified, but the bulk of unidentified bacterial isolates were mainly mixed colonies of rods, cocci, coccobacilli. and some filamentous types. Six‐hour agar settle‐plate counts during sandstorms were 1(X) and 40% higher for bacteria and fungi, respectively, than without sandstorms. The most abundant aeroallergens were those of Acacia, Alternaria, Aspergillus, Bermuda grass, Ciadosporium, cultivated rye, Prosopis, and cat dander. Pithecellobium duke, Rumex crispus, and Washingtonia palm allergens were detectable for the first time in Riyadh. IgE reactivities ofthe dust in man were demonstrated by ELISA using sera from atopic, exposed, and normal subjects. These results indicate that sandstorm dust is a prolific source of potential triggers of allergic and nonallergic respiratory ailments, and the methods mentioned here should be routinely used for quick sampling of the environment.
Global Health Metrics and Evaluation—a call for abstracts
Authors: Zulfiqar Bhutta, Mickey Chopra, Louisa Degenhardt, E. Michael Foster, Julio Frenk, Ramiro Guerrero, Richard Horton, Alan Lopez, Fatima Marinho de Souza, Felix Masiye, Kim Mulholland, Peter Piot, Christopher Murray, K. Srinath Reddy, Kenji Shibuya
Journal: The Lancet (2010)
Intraoperative Transesophageal Echocardiography and Epiaortic Ultrasound for Assessment of Atherosclerosis of the Thoracic Aorta11This study was supported in part by a Minority Scientist Development Award from the American Heart Association, Dallas, Texas, to Dr. Dávila-Román.
Authors: VÍCTOR G DÁVILA-ROMÁN, KENNETH J PHILLIPS, BILL B DAILY, ROSA M DÁVILA, NICHOLAS T KOUCHOUKOS, BENICO BARZILAI
Journal: Journal of the American College of Cardiology (1996)
Limitin: An interferon-like cytokine that preferentially influences B-lymphocyte precursors
Authors: Kenji Oritani, Kay L. Medina, Yoshiaki Tomiyama, Jun Ishikawa, Yu Okajima, Megumu Ogawa, Takahumi Yokota, Keisuke Aoyama, Isao Takahashi, Paul W. Kincade, Yuji Matsuzawa
Journal: Nature Medicine (2000)
Genomic instability in Gadd45a-deficient mice
Authors: M. Christine Hollander, M. Saeed Sheikh, Dmitry V. Bulavin, Karen Lundgren, Laura Augeri-Henmueller, Ronald Shehee, Thomas A. Molinaro, Kate E. Kim, Eva Tolosa, Jonathan D. Ashwell, Michael P. Rosenberg, Qimin Zhan, Pedro M. Fernández-Salguero, William F. Morgan, Chu-Xia Deng, Albert J. Fornace
Journal: Nature Genetics (1999)
HbA1c as a Predictor of Diabetes and as an Outcome in the Diabetes Prevention Program: A Randomized Clinical Trial
Authors: William C. Knowler, Sharon L. Edelstein, Ronald B. Goldberg, Ronald T. Ackermann, Jill P. Crandall, Jose C. Florez, Sarah E. Fowler, William H. Herman, Edward S. Horton, Steven E. Kahn, Kieren J. Mather, David M. Nathan
Journal: Diabetes Care (2014)

OBJECTIVE Glycated hemoglobin (HbA1c), a standard measure of chronic glycemia for managing diabetes, has been proposed to diagnose diabetes and identify people at risk. The Diabetes Prevention Program (DPP) was a 3.2-year randomized clinical trial of preventing type 2 diabetes with a 10-year follow-up study, the DPP Outcomes Study (DPPOS). We evaluated baseline HbA1c as a predictor of diabetes and determined the effects of treatments on diabetes defined by an HbA1c ≥6.5% (48 mmol/mol). RESEARCH DESIGN AND METHODS We randomized 3,234 nondiabetic adults at high risk of diabetes to placebo, metformin, or intensive lifestyle intervention and followed them for the development of diabetes as diagnosed by fasting plasma glucose (FPG) and 2-h postload glucose (2hPG) concentrations (1997 American Diabetes Association [ADA] criteria). HbA1c was measured but not used for study eligibility or outcomes. We now evaluate treatment effects in the 2,765 participants who did not have diabetes at baseline according to FPG, 2hPG, or HbA1c (2010 ADA criteria). RESULTS Baseline HbA1c predicted incident diabetes in all treatment groups. Diabetes incidence defined by HbA1c ≥6.5% was reduced by 44% by metformin and 49% by lifestyle during the DPP and by 38% by metformin and 29% by lifestyle throughout follow-up. Unlike the primary DPP and DPPOS findings based on glucose criteria, metformin and lifestyle were similarly effective in preventing diabetes defined by HbA1c. CONCLUSIONS HbA1c predicted incident diabetes. In contrast to the superiority of the lifestyle intervention on glucose-defined diabetes, metformin and lifestyle interventions had similar effects in preventing HbA1c-defined diabetes. The long-term implications for other health outcomes remain to be determined.
THE RESPONSE OF ACROMEGALY TO DEEP ROENTGEN-RAY THERAPY: A CASE REPORT
Authors: Albert Weinstein
Journal: Annals of Internal Medicine (1939)

Case Reports1 October 1939THE RESPONSE OF ACROMEGALY TO DEEP ROENTGEN-RAY THERAPY: A CASE REPORTALBERT WEINSTEIN, M.D.ALBERT WEINSTEIN, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-13-4-715 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThere is ordinarily no difficulty associated with the diagnosis of typical acromegaly. Following the classical descriptions by Marie,1the disorder became recognized as one of rather frequent occurrence. Nevertheless, the treatment of acromegaly has remained unsatisfactory. Occasionally the underlying pathological changes in the pituitary are such that the symptoms and signs are chiefly those of a space-occupying, hypophyseal tumor. Under such circumstances and especially when vision is threatened by pressure on the optic chiasma, the inclination is to regard and treat the disorder from the view-point of tumor formation rather than hormonal dysfunction. On the other hand, when signs of...References1. MARIE P: Sur deux cas d'acromégalie; hypertrophie singulière non congénitale des extrémités supérieures, inférieures et céphalique, Rev. de méd., 1886, vi, 297-333. Google Scholar2. BÉCLÈRE A: The radio-therapeutic treatment of tumours of the hypophysis, gigantism and acromegaly, Arch. Roent.-Ray, 1909-10, xiv, 142. GRAMAGNA: Un cas d'acromégalie traité par la radiothérapie, Rev. Neurol., 1909; Quoted by Béclère. WEBSTER, J. H. D.: Roentgen ray treatment of a case of early acromegaly, Arch. Radiol. and Electro-Therap., 1920-21, xxiv, 261. TOWNE, E. B.: Roentgen-ray treatment of pituitary tumors, Arch. Neurol. and Psychiat., 1926, xv, 92. GALLINO, M. M., and GALLINO, A. A.: Roentgenterapia de los tumores de la hipofisis, Semana med., 1933, ii, 1486-1491. CrossrefGoogle Scholar3. MEAGHERHEUER RGJ: A text-book of medicine, edited by R. L. Cecil, W. B. Saunders Co., Philadelphia, Third Edition, 1935, page 1236. Google Scholar4. CUSHING H: The pituitary body and its disorders, 1912, J. B. Lippincott Co., Philadelphia, page 235. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Nashville, Tennessee*Received for publication June 6, 1938.From the Department of Medicine, Vanderbilt University School of Medicine. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 October 1939Volume 13, Issue 4Page: 715-721KeywordsAcromegalySigns and symptomsVision ePublished: 1 December 2008 Issue Published: 1 October 1939 PDF downloadLoading ...
Superior Sulkus ve Santral T4 Küçük Hücreli Dışı Akciğer Kanserlerinde Üç Modaliteli Tedaviler Sonrası Sağkalım
Authors: Paul De Leyn, Johan Vansteenkiste, em> Yolande Lievens, em> Dirk Van Raemdonck, Philippe Nafteux, Georges Decker, Willy Coosemans, Herbert Decaluwé, Johny Moons, MScM, Tony Lerut
Journal: Journal of Thoracic Oncology (2009)