tbuckley/cabot-search huggingface dataset:
Meta-analysis of genome-wide association data and large-scale replication identifies additional susceptibility loci for type 2 diabetes
Authors: Eleftheria Zeggini, Laura J Scott, Richa Saxena, Benjamin F Voight, Jonathan L Marchini, Tianle Hu, Paul IW de Bakker, Gonçalo R Abecasis, Peter Almgren, Gitte Andersen, Kristin Ardlie, Kristina Bengtsson Boström, Richard N Bergman, Lori L Bonnycastle, Knut Borch-Johnsen, Noël P Burtt, Hong Chen, Peter S Chines, Mark J Daly, Parimal Deodhar, Chia-Jen Ding, Alex S F Doney, William L Duren, Katherine S Elliott, Michael R Erdos, Timothy M Frayling, Rachel M Freathy, Lauren Gianniny, Harald Grallert, Niels Grarup, Christopher J Groves, Candace Guiducci, Torben Hansen, Christian Herder, Graham A Hitman, Thomas E Hughes, Bo Isomaa, Anne U Jackson, Torben Jørgensen, Augustine Kong, Kari Kubalanza, Finny G Kuruvilla, Johanna Kuusisto, Claudia Langenberg, Hana Lango, Torsten Lauritzen, Yun Li, Cecilia M Lindgren, Valeriya Lyssenko, Amanda F Marvelle, Christa Meisinger, Kristian Midthjell, Karen L Mohlke, Mario A Morken, Andrew D Morris, Narisu Narisu, Peter Nilsson, Katharine R Owen, Colin NA Palmer, Felicity Payne, John R B Perry, Elin Pettersen, Carl Platou, Inga Prokopenko, Lu Qi, Li Qin, Nigel W Rayner, Matthew Rees, Jeffrey J Roix, Anelli Sandbæk, Beverley Shields, Marketa Sjögren, Valgerdur Steinthorsdottir, Heather M Stringham, Amy J Swift, Gudmar Thorleifsson, Unnur Thorsteinsdottir, Nicholas J Timpson, Tiinamaija Tuomi, Jaakko Tuomilehto, Mark Walker, Richard M Watanabe, Michael N Weedon, Cristen J Willer, Thomas Illig, Kristian Hveem, Frank B Hu, Markku Laakso, Kari Stefansson, Oluf Pedersen, Nicholas J Wareham, Inês Barroso, Andrew T Hattersley, Francis S Collins, Leif Groop, Mark I McCarthy, Michael Boehnke, David Altshuler
Journal: Nature Genetics (2008)
Proliferation and differentiation of erythroid progenitors in liquid culture: Analysis of progenitors derived from patients with polycythemia vera
Authors: Eitan Fibach, Eliezer A. Rachmilewitz
Journal: American Journal of Hematology (1990)

Abstract We have recently described a new two‐phase liquid culture that supports the development of human erythroid progenitors (Fibach et al., Blood 73:100, 1989). The procedure separates the erythroid burst‐forming units (BFUe) from the erythroid colony‐forming units (CFUe) stage and enables quantitation of the proliferation and differentiation of BFUe into CFUe. In the present study we have utilized this system to study erythroid progenitors in polycythemia vera (PV). The abnormality of the erythroid series in PV has been shown to be associated with an increased responsiveness of the progenitors to the hormone erythropoietin (Epo). A basic question in this clonal stem cell disorder is at what developmental stage this abnormality of the PV clone is phenotypically expressed. We have studied this question by comparing the development of Epo‐dependent and Epo‐independent CFUe from peripheral blood BFUe of the PV patient during the BFUe to CFUe transition in the liquid culture. The results indicated that both types of CFUe are generated and that in all cases tested the ratio of Epo‐independent progenitors at both the BFUe and CFUe stage was similar indicating no preferential development of Epoindependent CFUe. These results suggest that the abnormality of the PV erythroid progenitors is expressed only at the CFUe level. Moreover, since the liquid culture did not contain Epo, the results also support the conclusion that BFUe do not require Epo for proliferation or differentiation into CFUe.
Plague and Pregnancy
Authors: Jonathan M. Mann
Journal: JAMA (1977)

PLAGUE, like other severe systemic illnesses acquired during pregnancy, may cause spontaneous abortion.<sup>1</sup>In his comprehensive review of plague, Pollitzer<sup>2</sup>noted, "Unless specific treatment is started early, serious attacks of plague in any form usually lead to abortion or miscarriage in pregnant patients, events which exert a most unfavorable influence on the outcome of the illness." Descriptions of plague during pregnancy are principally derived from the preantibiotic era.<sup>1,2</sup>This communication describes a case of bubonic plague that occurred in a pregnant woman from Santa Fe, NM, during the 1975 plague season. <h3>Report of a Case</h3> A 28-year-old woman in her fifth month of pregnancy was examined by one of us (R.M.) at a Santa Fe hospital on Sept 15, 1975; her chief complaints were chills, fever, and a painful right inguinal swelling of 12 hours' duration. The patient and her family had recently moved into a house
UTERINE ADENOMATA IN THE RABBIT
Authors: Harry S. N. Greene
Journal: The Journal of Experimental Medicine (1939)

The behavior of a transplanted adenocarcinoma of the uterus of a rabbit has been studied through 12 serial generations in the anterior chamber of the eye and 6 serial generations in the testicle. The transplanted tumor is characterized by slow growth which is at first expansive and later invasive, by an ability to form more or less differentiated structures in response to different environmental conditions and by late metastasis. The endocrinological changes that distinguish animals bearing the spontaneous tumor do not occur in animals bearing the transplanted tumor. Various experiments were undertaken in an attempt to discover the nature of the factors determining the characteristics of the spontaneous and of the transplanted tumor. It was found that successful transplantation was followed by a phase during which animals were refractory to reinoculation. The results of transplantation into the eyes of animals with spontaneous tumors suggested the existence of a similar phase during the early development of the tumor but the number of observations was not sufficiently numerous to warrant definite conclusions.
Abdominal Pain and Subcutaneous Nodules
Authors: Kurt A. Ashack, Rebecca M. Jansen, Henry W. Lim
Journal: JAMA (2014)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The in vivo effect of UVB radiation on lymphocyte function
Authors: W.L. Morison, J.A. Parrish, K.J. Bloch
Journal: British Journal of Dermatology (1978)

Journal Article The in vivo effect of UVB radiation on lymphocyte function Get access W.L. Morison, W.L. Morison Boston, Massachusetts, U.S.A. Search for other works by this author on: Oxford Academic Google Scholar J.A. Parrish, J.A. Parrish Boston, Massachusetts, U.S.A. Search for other works by this author on: Oxford Academic Google Scholar K.J. Bloch K.J. Bloch Boston, Massachusetts, U.S.A. Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 99, Issue s16, 1 December 1978, Page 21, https://doi.org/10.1111/j.1365-2133.1978.tb15218.x Published: 01 December 1978
The Parathyroid Adenoma
Authors: Stanford Wessler
Journal: JAMA (1968)

Dr. William Clark, Junior Assistant Resident in Medicine, Jewish Hospital of St. Louis, and Assistant in Medicine, Washington University School of Medicine: The patient is a 68-year-old retired white woman who entered Jewish Hospital for the fourth time on June 27, 1967, with the chief complaint of abdominal pain. In October 1964 she had been admitted because of gastrointestinal bleeding attributed to indomethicin therapy for osteoarthritis, and a gastric ulcer was found roentgenographically. On reexamination four months later, the ulcer had completely healed. The patient had been essentially asymptomatic until one month before the present admission when she experienced recurrent burning epigastric pain, weight loss, and fatigue. The patient also had had hypertension and severe bitemporal headaches for many years which persisted despite therapy. Blood pressure in both arms was 200 mm Hg systolic and 100 mm Hg diastolic in the recumbent position, and her pulse was regular at 80
Allergy to Pollen from Different Deciduous Trees in Sweden
Authors: Nils E. Eriksson
Journal: Allergy (1978)

92 adult patients with springtime allergy were investigated with skin tests, provocation tests and the RAST. Allergen extracts from 12 different deciduous trees were used. Positive reactions, often of high intensity, were most often found with birch, alder, bog‐myrtle, beech and hazel allergens whereas oak, aspen, linden, elm, sallow, maple and poplar allergens more often gave negative or only weak positive test results. Cross sensitizations were found between botanically related as well as between less related species of the trees. Almost all patients with a clinically relevant tree pollen allergy had positive provocation tests with birch pollen. No patient had positive reactions to all the 12 allergens included in the study. 68% had positive provocation tests with the combination birch, alder and hazel. It is concluded that for diagnostic screening purposes it is sufficient to use birch pollen allergen. If the majority of relevant tree pollens are to be included in a diagnostic or therapeutic programme in Western Sweden it should contain birch, alder, hazel, beech and bog‐myrtle allergens.
Reduced volume fraction of myofibrils in myocardium of patients with decompensated pressure overload.
Authors: F Schwarz, J Schaper, D Kittstein, W Flameng, P Walter, W Schaper
Journal: Circulation (1981)

The relation between quantitative ultrastructural changes of the left ventricular (LV) myocar- dium and contractile function was studied in patients with chronic aortic stenosis (AS).The volume fractions of myofibrils, sarcoplasm and mitochondria in myocardial cells were determined by electron microscopic morphometry in small LV tissue samples of 19 patients with AS.Interstitial fibrosis was measured by light microscopic morphometry.Transmural biopsies of the LV free wall perfused by the anterior descending branch of the left anterior descending coronary artery (LAD) were obtained during aortic valve replacement.LV function was analyzed from preoperative right-and left-heart catheterization and angiography.Group 1 consisted of seven patients with ejection fractions (EFs) greater than 55% and mean left atrial pressure (LAP) less than 15 mm Hg.Group 2 consisted of 12 patients with EFs less than 55% and mean LAP greater than 15 mm Hg.Patients in group 1 had lower LV end-diastolic volume (91.9 vs 145.3 ml/m2, p < 0.05) and lower LV muscle mass (148.3 vs 199.8 g/m2, p < 0.05) than patients in group 2. The volume fraction of myofibrils was higher in group 1 than in group 2 (48.4 vs 42.1%, p < 0.05), while volume fractions of sarcoplasm (31.7 vs 36.0%) and mitochondria (20.9 vs 22.0%) were comparable (p > 0.05).Interstitial myocardial fibrosis did not differ between groups (16.3 vs 14.7%, p > 0.05).Biopsies from the area perfused by the LAD in 10 additional surgical patients who had coronary artery disease with moderate LAD stenosis and normal wall motion in the area of LV free wall perfused by the LAD were taken as controls for morphometric data.No significant difference of ultrastructural data was found between group 1 and controls.The volume fraction of myofibrils was lower in group 2 than in controls (42.1 vs 52.9%, p < 0.001), and the volume fraction of sarcoplasm was higher (36.0 vs 21.1%, p < 0.001).Mitochondria and interstitial fibrosis did not differ in group 2 and controls (p > 0.05).Thus, intracellular reduction in the volume fraction of myofibrils was the major morphologic finding in LV biopsy samples of patients with decompensated pressure overload.
A method for measuring the rate of oxygen release from single microvessels.
Authors: N Tateishi, N Maeda, T Shiga
Journal: Circulation Research (1992)

A system determining the rate of oxygen release from erythrocytes flowing in single microvessels was constructed with an inverted microscope by connecting 1) a scanning/grating spectrophotometer equipped with a photon-counting detector through a thin light guide, to obtain the visible absorption spectrum of a spot (5 microns in diameter) focused on a microvessel, 2) two photomultipliers (connected to a microcomputer via an analog-to-digital converter) through two light guides, to determine the flow velocity of erythrocytes by calculating the cross correlation between the light-intensity changes of two spots (3 microns in diameter, 5 microns apart from each other) focused on the microvessel, and 3) an image processor through a video camera, to estimate the diameter of microvessel from the digitized video images. The rate of oxygen release from single microvessels 7-25 microns in diameter in rat mesentery was measured under the superfusion of deoxygenated solution: 1) The maximal rate was obtained in capillaries, and the rate in arterial microvessels was larger than that in venous microvessels, when similar diameters were compared. 2) The rate was maximum at pH 7.0-7.2, and it decreased in more acidic and alkaline pH values. 3) The rate decreased with a decrease in temperature. The reliability of the measurement using the present apparatus was tested in detail.
Early Application of Positive End-Expiratory Pressure in Patients at Risk for the Adult Respiratory-Distress Syndrome
Authors: Paul E Pepe, L. D. Hudson, C. J. Carrico
Journal: New England Journal of Medicine (1984)

Previous studies have suggested that the early application of positive end-expiratory pressure (PEEP) reduces the incidence of the adult respiratory-distress syndrome. We randomly assigned 92 patients with a known risk for this syndrome to receive mechanical ventilation either without PEEP (control) or with early PEEP at 8 cm H2O. These therapies continued for 72 hours unless respiratory distress developed or arterial oxygen tension was above 140 (fractional inspired oxygen concentration, 0.5) at 24 hours or later and remained at that level after removal of PEEP. The study was designed to have an 80 per cent probability of detecting a 60 per cent reduction in the incidence of the syndrome. The treatment groups were comparable in age, severity of injury, number and type of risk factors for adult respiratory-distress syndrome, and initial oxygenation. The syndrome developed in 11 of 44 patients given early PEEP (25 per cent) and in 13 of 48 control patients (27 per cent). The incidence of atelectasis, pneumonia, and barotrauma was the same in both groups, as was mortality. We found that the early application of PEEP at 8 cm H2O in high-risk patients had no effect on the incidence of the adult respiratory-distress syndrome or other, associated complications. (N Engl J Med 1984; 311:281–6.)
Herpes Simplex Encephalitis as a Potential Cause of Anti–<i>N</i>-Methyl-<scp>d</scp>-Aspartate Receptor Antibody Encephalitis
Authors: Allen DeSena, Donna Graves, Worthy Warnack, Benjamin M. Greenberg
Journal: JAMA Neurology (2014)

Encephalitis mediated by anti-N-methyl-D-aspartate (NMDA) receptor antibodies and herpes simplex (HS) encephalitis are seemingly separate causes of encephalopathy in adults and children. Herpes simplex encephalitis is infectious, and anti-NMDA receptor antibody encephalitis is autoimmune in origin. Both can cause seizures and encephalopathy, although the latter can also cause psychiatric symptoms and movement disorders. Owing to the rarity of these 2 diseases, patients with co-occurrence are important because they alert clinicians to possible links between 2 seemingly separate processes.In a case series of 2 patients observed at our center, we describe an infant and an adult who had confirmed HS encephalitis and then developed confirmed anti-NMDA receptor antibody encephalitis. Polymerase chain reaction testing for HS virus was performed. Testing for NMDA receptor antibodies was performed by Associated Regional and University Pathologists Laboratory in Salt Lake City, Utah.We conclude that atypical cases of HS or other viral encephalitides should be investigated for concomitance of an autoimmune encephalitis. We suspect that the pathophysiologic mechanisms by which HS virus infects neurons produce a higher likelihood of contracting anti-NMDA receptor antibody encephalitis.
NIH: Handle with Care
Authors: Julius R. Krevans
Journal: New England Journal of Medicine (1980)

Congress is currently considering legislation (H.R. 7036, the Health Research Act of 1980, and S.988, the Health Sciences Promotion Act of 1979) that would radically alter the mechanisms by which the National Institutes of Health relate to Congress. Although desirable features can be found in both these bills, their central themes presage a new and different style of operation. The Health Research Act replaces the permanent authority under which most of the institutes are governed with time-limited (triennial) authority and a ceiling on expenditures for each institute. The Health Sciences Promotion Act originally contained an essentially identical proposal, but its . . .
Role of Cardiac Magnetic Resonance Imaging in the Detection of Cardiac Amyloidosis
Authors: Imran S. Syed, James F. Glockner, DaLi Feng, Philip A. Araoz, Matthew W. Martinez, William D. Edwards, Morie A. Gertz, Angela Dispenzieri, Jae K. Oh, Diego Bellavia, A. Jamil Tajik, Martha Grogan
Journal: JACC. Cardiovascular imaging (2010)
RENAL INSUFFICIENCY IN THE TROPICS.
Authors: JAMES CABELL MINOR
Journal: JAMA (1902)

Without touching on the theories of Garrod and Latham on the one side and Haig and his followers on the other as to the origin, effect and disposition of uric acid, which theories prove ever debatable, the writer of this paper passes to the more simple and practical consideration of a certain condition of the blood which conclusively announces the fact that the kidneys are not performing their function and that the condition is one of danger. For the purposes of this essay the cause of "this certain condition" will be referred to as "urinary solids." Renal insufficiency is failure on the part of the kidney to perform its function. A more practical title to this paper would be, a plea for systematic instruction in the use of water in the tropics. Lack of volume to the circulation means renal insufficiency sooner or later, whether the failure in function on
Review: Reduced function CYP2C19 genotypes may increase risk for stent clots in patients receiving clopidogrel
Authors: Tracy Y Wang, Christopher B Granger
Journal: Annals of Internal Medicine (2011)

Source Citation Bauer T, Bouman HJ, van Werkum JW, et al. Impact of CYP2C19 variant genotypes on clinical efficacy of antiplatelet treatment with clopidogrel: systematic review and meta-analysis. BMJ. 2011;343:d4588. 21816733
Comparison of thrice-daily premixed insulin (insulin lispro premix) with basal-bolus (insulin glargine once-daily plus thrice-daily prandial insulin lispro) therapy in east Asian patients with type 2 diabetes insufficiently controlled with twice-daily premixed insulin: an open-label, randomised, controlled trial
Authors: Weiping Jia, Xinhua Xiao, Qiuhe Ji, Kyu-Jeung Ahn, Lee-Ming Chuang, Yuqian Bao, Can Pang, Lei Chen, Fei Gao, Yinfang Tu, Pengfei Li, Jun Yang
Journal: The Lancet Diabetes & Endocrinology (2015)
Cognitive Impairment Associated With Atrial Fibrillation
Authors: Shadi Kalantarian, Theodore A. Stern, Moussa Mansour, Jeremy N. Ruskin
Journal: Annals of Internal Medicine (2013)

Background: Atrial fibrillation (AF) has been linked with an increased risk for cognitive impairment and dementia. Purpose: To complete a meta-analysis of studies examining the association between AF and cognitive impairment. Data Sources: Search of MEDLINE, PsycINFO, Cochrane Library, CINAHL, and EMBASE databases and hand search of article references. Study Selection: Prospective and nonprospective studies reporting adjusted risk estimates for the association between AF and cognitive impairment. Data Extraction: Two abstracters independently extracted data on study characteristics, risk estimates, methods of AF and outcome ascertainment, and methodological quality. Data Synthesis: Twenty-one studies were included in the meta-analysis. Atrial fibrillation was significantly associated with a higher risk for cognitive impairment in patients with first-ever or recurrent stroke (relative risk [RR], 2.70 [95% CI, 1.82 to 4.00]) and in a broader population including patients with or without a history of stroke (RR, 1.40 [CI, 1.19 to 1.64]). The association in the latter group remained significant independent proof of clinical stroke history (RR, 1.34 [CI, 1.13 to 1.58]). However, there was significant heterogeneity among studies of the broader population (I 2 = 69.4%). Limiting the analysis to prospective studies yielded similar results (RR, 1.36 [CI, 1.12 to 1.65]). Restricting the analysis to studies of dementia eliminated the significant heterogeneity (P = 0.137) but did not alter the pooled estimate substantially (RR, 1.38 [CI, 1.22 to 1.56]). Limitations: There is an inherent bias because of confounding variables in observational studies. There was significant heterogeneity among included studies. Conclusion: Evidence suggests that AF is associated with a higher risk for cognitive impairment and dementia, with or without a history of clinical stroke. Further studies are required to elucidate the association between AF and subtypes of dementia as well as the cause of cognitive impairment. Primary Funding Source: Deane Institute for Integrative Research in Atrial Fibrillation and Stroke at the Massachusetts General Hospital.
HLA and Renal Transplantation
Authors: Charles B. Carpenter
Journal: New England Journal of Medicine (1980)

The realization that tissues express the antigenic individuality of the host began with Landsteiner's discovery of the major red-cell groups shortly after the turn of the century.1 The role of typing and cross-matching in blood transfusion is certainly well established, and, in a sense, represents a simple model for approaching the problem of matching other tissues for transplantation. Although the matching of leukocyte antigens of the HLA system encoded on Chromosome 6 is of unquestioned importance to the survival of renal allografts from living related donors, its predictive value in cadaveric transplantation has been the subject of much debate over . . .
Long-term outcome of patients with prior percutaneous revascularization undergoing repeat coronary intervention
Authors: Heidar Arjomand, David R. Holmes, James T. Willerson, Bassam Roukoz, Satish Surabhi, Andrey Espinoza, Daniel McCormick, Zoltan G. Turi, Sheldon Goldberg
Journal: Journal of the American College of Cardiology (2003)