THE USE OF THIOURACIL IN THE TREATMENT OF PATIENTS WITH HYPERTHYROIDISM
Authors: J. L. Gabrilove, M. J. Kert, L. J. Soffer
Journal: Annals of Internal Medicine (1945)

Article1 October 1945THE USE OF THIOURACIL IN THE TREATMENT OF PATIENTS WITH HYPERTHYROIDISMJ. L. GABRILOVE, M.D., M. J. KERT, M.D., L. J. SOFFER, M.D.J. L. GABRILOVE, M.D.Search for more papers by this author, M. J. KERT, M.D.Search for more papers by this author, L. J. SOFFER, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-23-4-537 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptHISTORICAL REVIEWThe origin of the use of thiouracil in the treatment of hyperthyroidism stems from the past studies of the mechanism of the production of experimental goiter. During the course of these studies in which the rôle of iodine in the production of simple goiter was convincingly demonstrated, many interesting facts were unearthed that were to be of striking importance in the development of the rationale for the use of thiourea derivatives in the treatment of hyperthyroidism.In 1928, Chesney and his co-workers1noted the development of goiter in their stock rabbits fed on a cabbage diet. The thyroid...Bibliography1. CHESNEYCLAWSONWEBSTER AMTAB (a) : Incidence and characteristics of endemic goiter in rabbits, Bull. Johns Hopkins Hosp., 1928, xliii, 261. (b) WEBSTER, B., CLAWSON, T. A., and CHESNEY, A. M.: Heat production in goitrous and non-goitrous animals, Bull. Johns Hopkins Hosp., 1928, xliii, 278. (c) WEBSTER, B., and CHESNEY, A. M.: Effect of administration of iodine on endemic goiter in rabbits, Bull. Johns Hopkins Hosp., 1928, xliii, 291. Google Scholar2. WEBSTERCHESNEY BAM: Studies in the etiology of simple goiter, Am. 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PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byMedical Treatment of Systemic Graves’ DiseaseAgranulocytosis Associated with Antithyroid Drugs Effects of Patient Age and Drug DoseDAVID S. COOPER, M.D., DAVID GOLDMINZ, B.S., ANN A. LEVIN, M.S., PAUL W. LADENSON, M.D., GILBERT H. DANIELS, M.D., MARK E. MOLITCH, M.D., E. CHESTER RIDGWAY, M.D.Thiouracil: Remission or relapse of hyperthyroidism after discontinuing its use 1 October 1945Volume 23, Issue 4Page: 537-558KeywordsDietHyperthyroidismMedical servicesPatientsRabbitsRiversThyroid ePublished: 1 December 2008 Issue Published: 1 October 1945 PDF downloadLoading ...