tbuckley/cabot-search huggingface dataset:
Abstract 2200: Variability in Post-pacing Intervals Predicts Global Atrial Activation Pattern During Tachycardia
Authors: Ilyas K Colombowala, Ali G Massumi, Abdi Rasekh, Mohammad Saeed, Jie Cheng, Bita Fakhri, Mossaab Shuraih, Mehdi Razavi
Journal: Circulation (2007)

Background: Knowledge of the global atrial activation pattern is critical to ablation of an atrial arrhythmia. We hypothesized that the variability in post-pacing intervals (PPI) with pacing at different cycle lengths (CL) from the same pacing site, regardless of distance to the circuit, can be used to identify atrial activation patterns during tachycardia. Methods and Results: Patients referred for ablation of SVT were included (n=28, 31 total tachycardias). During tachycardia, overdrive atrial pacing was performed. The variability in PPIs (PPIV) was calculated by comparing the difference in PPIs after overdrive pacing at trains 10, 20, and 30 ms shorter than the tachycardia cycle length (TCL). The global activation pattern was defined as circuitous (grossly visible circuit) or centrifugal (focal origin with centrifugal radiation) by electroanatomic mapping. Except for one case, all pacing was performed from the proximal CS bipole. Circuitous tachycardias exhibited minimal variability with pacing at 10 ms and 30 ms shorter than TCL (6.0±2.5 ms), whereas centrifugal tachycardias displayed a high degree of variability (56.5±20.6 ms, 8 of 14 were micro-reentrant). Rank sum analysis of PPIV suggests that the two groups are indeed distinct (P&lt;0.001). Using PPIV cutoffs of ≤10 ms and ≥30 ms, circuitous and centrifugal activation patterns were classified with a high degree of sensitivity (94% circuitous, 92.8% centrifugal) and 100% specificity. Conclusion: Our data supports the use of PPIV to rapidly and accurately predict global activation pattern during atrial arrhythmia.
What's the deal with follicular lymphomas?
Authors: D L Longo
Journal: Journal of Clinical Oncology (1993)

Article Tools Article Tools OPTIONS & TOOLS Export Citation Track Citation Add To Favorites Rights & Permissions COMPANION ARTICLES No companion articles ARTICLE CITATION DOI: 10.1200/JCO.1993.11.2.202 Journal of Clinical Oncology - published online before print September 21, 2016 PMID: 8426195 What's the deal with follicular lymphomas? D L LongoxD L LongoSearch for articles by this author https://doi.org/10.1200/JCO.1993.11.2.202 First Page PDF © 1993 by American Society of Clinical Oncology
Abstract 16050: Microrna-21 Regulates Expansion of Abdominal Aortic Aneurysms Through the PTEN/PI3K/AKT Pathway
Authors: Lars Maegdefessel, Junya Azuma, Alicia Deng, Ryuji M Toh, Denis R Merk, Azad Raiesdana, Nicholas J Leeper, Joshua M Spin, Philip S Tsao
Journal: Circulation (2011)

Successful identification, treatment, and limitation of abdominal aortic aneurysm (AAA) disease remain some of the biggest challenges in modern vascular medicine. The discovery that microRNAs (miRs...
Coming to terms with death (six poems) Charade The challenge The visit Pain Memories The meeting
Authors: I. Roddie
Journal: BMJ (1998)

Shall I compare thee to a...The five largest general medical journals like to refer to themselves as "the big five." This reminded Nairobi surgeon Imre Loefler of Africa's five big game animals, and he set about exploring the similarities in more detail.Next came ships.Given the opportunity for harmless fun and the chance to exact public revenge, we thought that other people might like to play this game, so we invited entries from visitors to our website (and one or two others).To Loefler's big game animals and ships were added cars, football teams, and Spice Girls.Taken together, they probably say more about the wellsprings of the male imagination than about medical journals.The game need not end here-submit your five-pack using the "rapid response" option on our website.
Abstract 11125: A Novel Algorithm to Distinguish Left-sided Posteroseptal Accessory Pathway and Right-sided Posteroseptal Accessory Pathway Using the Difference in the Beginning of the Delta Wave.
Authors: Tatsuya Hayashi, Koji Kumagai, Shigeto Naito, Suguru Nishiuchi, Etsuko Fuke, Chizuru Sato, Yuko Miki, Koji Goto, Tamotsu Sakamoto, Keijiro Nakamura, Rie Fukazawa, Kenihi Kaseno, Shigeru Oshima, Koichi Taniguchi
Journal: Circulation (2010)

Objectives:  The purpose of this study is to investigate an algorithm in the prediction of successful radiofrequency (RF) catheter ablation site of the posteroseptal accessory pathway (PSAP) in manifest Wolff-Parkinson-White (WPW) syndrome.   Background:  Although some algorithm of AP locations have been proposed previously, it remains still challenging to predict the successful ablation site. This is especially true for the PSAPs because it is difficult to distinguish between left-sided and right-sided PSAPs.   Methods:  Thirty-one patients undergoing ablation of manifest PS-APs were investigated in retrospective analyses. They were divided into two groups; group R: right-sided PSAP (n=23) and group L: left-sided PSAP (n=8). In addition to the conventional electrophysiological parameter, the interval time between the earliest onset of the delta wave in inferior leads and latest onset in precordial leads was defined as “delta-wave difference” in both groups. On the basis of these results, we evaluated usefulness of “delta-wave difference” for the detection of left-sided and right-sided approaches.   Results:  The delta-wave difference was prolonged significantly in the group L compared with the group R (group R: 11±11msec, group L: 29±11msec, p   Conclusions:  In patients with manifest WPW syndrome using PSAPs, the measurement of “delta wave difference” can be a good predictor to determine approach side for the successful ablation.
Abstract 13081: Predicting Non-response to NT-proBNP Guided Heart Failure Management Using the PROTECT Risk Score
Authors: Han-Na Kim, Quynh A Truong, Shafiq U Rehman, Asim A Mohammed, Anju Bhardwaj, Kimberly Parks, Dorothy Sullivan, Annabel Chen-Tournoux, Stephanie A Moore, Justine Barajas, Linda Barajas, Rory B Weiner, Aaron L Baggish, Marc J Semigran, James L Januzzi
Journal: Circulation (2011)

Background: N-terminal pro-B type natriuretic peptide (NT-proBNP) is strongly predictive of heart failure (HF) prognosis. Some patients respond to aggressive HF management with a significant reduction in NT-proBNP while others do not. This NT-proBNP “non-responder” profile is associated with higher risk as well as increased utilization of healthcare resources. We sought to predict “non-response” among ambulatory patients with HF due to left ventricular systolic dysfunction (LVSD). Methods: 151 HF patients with LVSD were studied in the ProBNP Outpatient Tailored Chronic HF Therapy (PROTECT) Trial. Variables at first office visit independently predictive of non-response (defined as NT-proBNP >1000 pg/mL following a mean of 10 months of study participation) were assembled in a risk score. Results: Four factors comprised the final PROTECT Non-responder Risk Score: baseline NT-proBNP value (3 points for NT-proBNP > 5000 pg/mL, 2 points for 1000-5000 pg/mL and 0 point for < 1000 pg/mL), NYHA class 3 or 4 (1 poi...
Abstract 2694: Ionic Mechanism by Which Adenosine Reveals “Dormant” Conduction in Pulmonary Veins
Authors: Tomas Datino, Laurent Macle, Xiao Yan Qi, Philippe Comtois, Denis Chartier, Peter G Guerra, Angel Arenal, Francisco Fernandez-Aviles, Stanley Nattel
Journal: Circulation (2009)

Adenosine (Ado) acutely reconnects “dormant” pulmonary veins (PVs) after RF ablation and is widely used in PV isolation procedures to identify PVs at risk of eventual reconnection. Purpose. To dete...
Abstract 15451: Carotid Stenosis in CABG-Patients: is There an Indication for Surgical Treatment?
Authors: Udo Boeken, Alexander Assmann, Payam Akhyari, Arash Mehdiani, Artur Lichtenberg
Journal: Circulation (2011)

Objective: Stroke after CABG-procedures is a rare but devastating complication that leads to excess morbidity and mortality. The role of a significant carotid stenosis in the pathogenesis of this c...
Outcome Of MDS and AML With MDS-Related Changes: Treatment Versus Prognostic Factors
Authors: Nadja Jaekel, Susann Schulze, Cora Graneist, Rainer Krahl, Wolfram Poenisch, Thoralf Lange, Vladan Vucinic, Georg Franke, Christian Pfrepper, Dietger Niederwieser, Haifa Kathrin Al-Ali
Journal: Blood (2013)
Complete Remission of Accelerated Phase Chronic Myeloid Leukemia by Treatment With Leukemia-Reactive Cytotoxic T Lymphocytes
Authors: J.H. Frederik Falkenburg, Amon R. Wafelman, Peter Joosten, Willem M. Smit, Cornelis A.M. van Bergen, Rian Bongaerts, Ellie Lurvink, Menno van der Hoorn, Petra Kluck, James E. Landegent, Hanneke C. Kluin-Nelemans, Willem E. Fibbe, Roel Willemze
Journal: Blood (1999)
Increased Rate of Stent Thrombosis and Target Lesion Revascularization After Filter Protection in Primary Percutaneous Coronary Intervention for ST-Segment Elevation Myocardial Infarction
Authors: Anne Kaltoft, Henning Kelbæk, Lene Kløvgaard, Christian Juhl Terkelsen, Peter Clemmensen, Steffen Helqvist, Jens Flensted Lassen, Leif Thuesen
Journal: Journal of the American College of Cardiology (2010)
Bat rabies
Authors: D. Pounder
Journal: BMJ (2003)

The death from rabies of a bat conservationist in Dundee last year was the first fatality since 1902 from rabies acquired in the United Kingdom. The lethal virus, isolated from brain tissue at autopsy, was not the classical rabies virus but a closely related negative stranded RNA virus, the European bat lyssavirus type 2.1 The genus lyssavirus, named after the Greek for “frenzy,” includes the classic rabies virus, two European bat lyssaviruses, an Australian bat lyssavirus, and the African Duvenhage virus, all of which produce a similar fatal encephalomyelitis in humans—rabies.

Rabies is mainly transmitted in saliva during a bite from an infected animal. In the United Kingdom classic rabies …
Abstract 761: Oral Anti-CD3 Antibody Treatment Induces CD4+LAP+ Regulatory T Cells and Ameliorates the Development of Atherosclerosis in Mice
Authors: Naoto Sasaki, Tomoya Yamashita, Hideto Tawa, Masafumi Takeda, Tomoya Masano, Masakazu Shinohara, Ryuji Toh, Seimi Kobayashi, Ken-ichi Hirata
Journal: Circulation (2007)

Background: Accumulating evidence suggests that several subsets of regulatory T cells (Tregs) which actively mediate immunologic tolerance play crucial roles in atherogenesis. Recently, orally admi...
Sustained remission in drug-free schizophrenic patients
Authors: W S Fenton, T H McGlashan
Journal: American Journal of Psychiatry (1987)

The inability to determine which schizophrenic patients do not require maintenance medication is a significant gap in current knowledge. This report describes 23 largely chronic DSM-III schizophrenic patients who, after a period of inpatient treatment, sustained good outcome without maintenance antipsychotic medication over an average of 15 years. Retrospective study of these patients revealed that their distinguishing characteristics at admission included better premorbid social and occupational adjustment, higher levels of accrued psychosocial competence and acquired skills, fewer hebephrenic traits, and the preservation of affect (depressed mood). Hence, even within a largely chronic patient sample, classic predictors of good outcome may also be useful in predicting sustained remission without medication.
Abstract 466: Valproic Acid Enhances Human Cord Blood CD34 <sup>+</sup> Cell Differentiation Toward The Endothelial Phenotype
Authors: Daniele Avitabile, Ilaria Burba, Andrea Biondi, Giulio Pompilio, Maurizio C. Capogrossi, Maurizio Pesce
Journal: Circulation (2007)

Background . Human umbilical cord blood (UCB) CD34 + cells are bi-potential progenitors that differentiate into hematopoietic and endothelial cells. Epigenetic control of gene expression by histone deacetylase (HDAC) activity is linked to lineage-decisions in uncommitted stem cells. Here we tested whether HDAC inhibitor valproic acid (VPA) modifies the balance between hematopoietic and endothelial commitment of CD34 + cells. Methods and results. UCB CD34 + cells selected by magnetic sorting were cultured in serum-free medium containing IL-3 and IL-6 (20 ng/ml), Stem Cell Factor and Flt3L (100 ng/ml) cytokines ±VPA (2.5mM) for 7 days. At day 0 CD34 + cells were 84.2±5.2%. After 1 week in culture CD34 expression exhibited a marked decrease and this effect was inhibited by VPA (CD34 + cells; 90.0±0.8% vs. 30.0±2.0%; n=4; P&lt;0.01). In contrast, VPA had a negative effect on CD34 + cell proliferation, as it induced G0/G1 arrest (cells in G0/G1; 93.0±0.9% vs. 74.1±4.3%; n=3; P&lt;0.05) and decreased the stem cell proliferation index (16.2±2.8% vs. 44.0±8.8%; n=3; P&lt;0.05) as well as total cell number. The negative effect of VPA on cell proliferation was associated with upregulation of p16 and p21 genes. VPA enhanced CD34 + cells stemness; it increased Rhodamine123 dye extrusion by CD34 + cells (Rhodamine 123 low ; 24.6 ± 6.8% vs 4.7 ± 1.1%; n=3; p&lt;0.05) and enhanced CD34 and GATA-2 genes expression. To assess the effects of VPA on CD34 + cells endothelial vs. hematopoietic commitment it was determined the expression of endothelial and hematopoietic markers at day 7. VPA enhanced CD146 + (76.7±5.7 vs 1.4±0.8; n=3; P&lt;0.05) and Ac-LDL-DiI + (88.3±6.7 vs 59.3±3.2; n=3; P&lt;0.05) cells. In contrast, CD14 + expressing cells were reduced (1.8±2.6% vs 7.7±4.0%; n=4; P&lt;0.05) and CD31 + , CD105 + , CD144 + and KDR + cells were unchanged. Finally, CD34 + cells cultured with VPA for 7 days and plated in endothelial differentiation medium for additional 7 days in fibronectin-coated dishes, formed adherent spindle-shaped cells resembling late EPCs outgrowths while control cells remained unattached and round resembling hematopoietic cells. Conclusions. VPA modulates UCB CD34 + cells stemness and cell cycle distribution; further, it enhances their commitment toward the endothelial phenotype.
Chronic cough in children: Testing - how much is too much?
Authors: Tina Lozej, Marina Praprotnik, Melanija Zupanic, Uros Krivec
Journal: European Respiratory Journal (2014)

Introduction:  Chronic cough is one of the most common complaints in children. It is mostly self-limiting illness. Detailed history and a thorough physical examination should be the cornerstone of its management and further testing should be rationally selected.   Aims and objectives : As asthma is an infrequent cause of chronic cough we wanted to find out whether exhaled nitric oxide (eNO) and spirometry are necessary investigations in these children.   Methods : We reviewed the medical records of all children with chronic cough (cough lasting more than 4 weeks) who were referred to our outpatient clinic in a 6 months period.   Results:  A total of 94 children (54.3 % girls) with the median age 5.0 years (range 0.75-17.5) were included in the study. Skin prick tests were performed in 95.7 % of all children (negative in 76.6 %) and eNO in 80.9 % (negative in 95 %). Spirometry was done in all children older than 5 years (n=54) and it was normal in 90.7 %. In selected cases other tests were also done (metacholine test, sweat test, X-ray, microbiology, etc).  Of the 94 patients, 58.5 % were diagnosed with postviral cough and 17.1 % with asthma. The remaining had psychogenic cough, GERD and OSAS.  eNO and spirometry have very low sensitivity (6 % and 0 %) and high specificity (96 % and 94 %) for asthma in chronic cough.   Conclusions:  Asthma is an uncommon cause of chronic cough in children. Due to their low sensitivity eNO and spirometry should not be routinely performed in these patients unless history and/or physical findings suggest otherwise.
Abstract 18417: Complex Interaction of the Prognostic Value of Systolic Blood Pressure with the Degree and Type of Heart Failure
Authors: Sameer Ather, Biykem Bozkurt, Wenyaw Chan, David Aguilar, Kumudha Ramasubbu, Anita Deswal
Journal: Circulation (2010)

Introduction: Low systolic blood pressure (SBP) is associated with higher mortality in heart failure (HF) patients whereas hypertension is associated with worse outcomes in patients without HF. How...
Heavy Metal Lead Exposure, Osteoporotic-like Phenotype in an Animal Model, and Depression of Wnt Signaling
Authors: Eric E. Beier, Jason R. Maher, Tzong-Jen Sheu, Deborah A. Cory-Slechta, Andrew J. Berger, Michael J. Zuscik, J. Edward Puzas
Journal: Environmental Health Perspectives (2012)

Exposure to lead (Pb) from environmental and industrial sources remains an overlooked serious public health risk. Elucidating the effect of Pb on bone cell function is therefore critical for understanding its risk associated with diseases of low bone mass.We tested the hypothesis that Pb negatively affects bone mass. We also assessed the underlying mechanisms of Pb on bone signaling pathways.We used a model of low-level Pb exposure in a rodent beginning before conception and continuing over 18 months. We characterized the effect of Pb on bone quality using dual-energy X-ray absorptiometry (DXA), micro-computed tomography, Raman spectroscopy, and histology. We assessed the effect of Pb on bone and adipocyte formation by mineral deposition, lipid droplet formation, and Western blot and RNA analysis.Pb-exposed animals had decreased bone mass that resulted in bones that were more susceptible to fracture. Pb decreased osteoblastic cell number leading to a depression of bone formation. Accompanying this, Pb exposure elevated sclerostin protein levels in the skeleton, and correspondingly reduced levels of β-catenin and Runx2 in stromal precursor cells. Pb also increased skeletal expression of peroxisome proliferator-activated receptor-γ (PPAR-γ). These results indicate a shift in mesenchymal differentiation wherein Pb promoted enhanced adipogenesis and decreased osteoblastogenesis. Substantial differences in bone marrow composition were observed, highlighted by an increase in adipocytes.The disruption Pb has on bone mass and bone homeostasis is principally explained by inhibition of the Wnt/β-catenin pathway, which may provide a molecular basis for novel therapeutic strategies to combat Pb-induced bone pathologies.
Ewing tumor cells grown as anchorage independent multicellular spheroids suppress anoikis through an E-cadherin dependent cell survival pathway.
Authors: Hyung-Gyoo Kang, Timothy J. Triche, Jasmine Jenabi, Poul Hb Sorensen
Journal: Cancer Research (2006)

Proc Amer Assoc Cancer Res, Volume 47, 2006

5637 

Most normal mammalian cells cannot survive if they become detached from the extracellular matrix (ECM), instead undergoing detached-induced programmed cell death or anoikis. However, a major hallmark of transformed cells is that they can survive under anchorage independent conditions including suspension cultures. During metastatic spread, tumor cells detach from primary sites and must then survive under anchorage independent conditions before establishing ECM contacts at distant metastatic sites. Understanding how these cells suppress anoikis is key to developing therapeutic strategies targeting micrometastases in the circulation or the bone marrow. To investigate the biological mechanisms underlying suppression of anoikis we analyzed the consequences of transferring Ewing tumor cell lines from conventional monolayers to anchorage independent cultures on agar-coated plates. This resulted in the rapid formation of multicellular tumor spheroids while single cells underwent cell death. While integrins mediated attachment of monolayer cells to plastic, spheroid formation was associated with E-cadherin mediated cell-cell adhesion. Ewing tumor spheroids showed a dramatic increase in chemoresistance to a wide spectrum of anti-neoplastic agents compared to monolayer cultures of the same cell lines, and this was reversed by blocking E-cadherin cell-cell contacts. Spheroid cells demonstrated increased activation of the Rac1 or Cdc42 GTPases, and dominant negative Rac1/cdc42 blocked spheroid cell survival. In addition, several receptor tyrosine kinases such as ErbB4, NTRK3, IGF1R and PDGFRβ became activated in spheroid cells. Of these, ErbB4 activation was found to be particularly high in Ewing tumor spheroids. These results indicate that anchorage independent Ewing tumor cells suppress anoikis through a pathway involving E-cadherin cell-cell adhesion, Rho GTPase activation, and stimulation of receptor tyrosine kinases.
Impact of Primary Laws on Adult Use of Safety Belts—United States, 2002
Authors: L F Beck, K A Mack, R A Shults
Journal: JAMA (2004)

The impact of primary laws on adult use of safety belts in U.S. is discussed in this paper. The data from the 2002 Behavioral Risk Factor Surveillance System (BRFSS) was analyzed by the Center for Disease Control. The results of that analysis indicated that the prevalence of self reported safety belt use was higher among states with primary laws than among states with secondary laws. The paper recommends that all states should enact primary laws to reduce deaths from motor vehicle crashes. The adult safety belt use in the U.S. ranks among the lowest of high income countries.
Abstract 17018: Plasma Concentrations of Galectin-3 in Patients with Suspected and Confirmed Heart Failure: Distribution, Associations and Prognostic Significance
Authors: Nasser S Sherwi, Kevin M Goode, Jufen Zhang, Rachel Nicholls, Ashraf Yassin, Kennth Wong, Andrew Clark, John Cleland
Journal: Circulation (2011)

Background: Plasma concentrations of galectin-3 predict outcome in patients with acute heart failure but have not been studied in a large epidemiologically-representative out-patient population. Aims: To explore the distribution, associations and prognostic significance of plasma concentrations of galectin-3 in patients with suspected heart failure of varied phenotypes. Methods: Patients referred to a heart failure clinic from the local population were invited to participate. Symptoms, signs and routine investigations, including spirometry, electro- and echo-cardiograms and blood tests, including NT-proBNP were systematically recorded. Patients were followed for four or more years. Results: Of 1,047 patients evaluated, 403 had no structural heart disease on echo, 508 had left ventricular (LV) systolic dysfunction, 76 had substantial valve disease and 108 had evidence only of ‘diastolic’ LV dysfunction. Plasma galectin-3 ranged (median IQR) from 14.8 (11.0 to 18.3)ng/ml in patients without overt disease to 19.5 (15.1-24.6)ng/ml in patients with LV systolic dysfunction and elevated NT-proBNP. Greater age, serum creatinine and white blood cell count, lower systolic blood pressure and female sex, but not LV function, predicted plasma galectin-3 but explained little of its variability (R 2 = 0.0300; p&lt;0.0001). During follow-up, 266 patients (25%) died, of which 145 were primarily for cardiovascular reasons. On univariate analysis and after correction for age and sex differences, the plasma concentration of galectin-3 was a strong predictor of all-cause mortality. Conclusions: Plasma galectin-3 is commonly increased in patients with heart failure but appears better related to renal function and NT-proBNP than LV ejection fraction. Plasma galectin-3 is strongly related to an adverse prognosis, which may be due, in part, to its relationship to renal function. Whether galectin-3 is a marker or mediator of cardiac and renal dysfunction remains to be determined.