tbuckley/cabot-search huggingface dataset:
Measuring the efficiency of health systems
Authors: M. McKee
Journal: BMJ (2001)

government's white paper Saving Lives: Our Healthier Nation (www.york.ac.uk/inst/crd/wph.htm).Other projects that provide cross disciplinary evidence for policymaking will follow.At the heart of the Campbell Collaboration is its methods groups.Their task is to ensure that reviewers use rigorous methods of research synthesis and to improve the quality of primary research and research synthesis in the social and political sciences.Currently, there are three Campbell methods groups: one on experimental methods, another on quasiexperimental methods, and the third on process and qualitative methods.Additional methods groups will follow.A Centre for Research Synthesis Methods, responsible for coordinating the methods activities of the collaboration, is soon to be established at the University of Missouri in the United States.The communications and dissemination group is the fourth core element of the collaboration, in addition to the international steering committee.This group provides guidance on, and strategic planning for, the dissemination work of the collaboration.The Campbell Collaboration is an international organisation.Its membership is drawn from 15 countries, with growing interest being shown in developing countries.The Nordic countries are well represented and are among its most active participants.The Danish Ministry of Social Affairs has allocated resources for a Nordic Campbell Centre in Copenhagen, and is negotiating with the Nordic Council of Ministers to secure the involvement of other countries.This will give the Collaboration a European base for training members in systematic review methods and other aspects of research synthesis, as well as a centre for undertaking and disseminating high quality systematic reviews on public policy issues.Funding for the Campbell Collaboration also comes from major research foundations, research charities, private philanthropists, and government sources.The Campbell Collaboration is a young organisation, founded in 1999.It works closely with other organisations throughout the world that promote evidence based policymaking.The collaboration does not make policy, nor does it proselytise, advise, or work as a pressure group.Its mission is to provide high quality, sound evidence for policymakers, practitioners, and the public to make well informed decisions about public policy.
Soluble METCAM/MUC18 blocks angiogenesis during the in vivo tumor formation of human prostate cancer LNCaP cells
Authors: Guang-Jer Wu, Eugene Lee Son
Journal: Cancer Research (2006)

Proc Amer Assoc Cancer Res, Volume 47, 2006

252 

Background. Human METCAM / MUC18 is a key determinant in increasing tumor-take and tumorigenesis and initiating metastasis of human prostate cancer LNCaP cells (a review by Wu, Current Genomics, 2005, 6, 333-349). To study the mechanisms, in this report we further study the effect of enforced expression of truncated human METCAM / MUC18 proteins, in which the cytoplasmic tail or both the cytoplasmic tail and the transmembrane domain were deleted, on tumor-take and tumorigenesis of LNCaP cells. Methods. The wild type and/or truncated human METCAM/MUC18-expressing LNCaP cells were subcutaneously co-injected with Matrigel to nude mice, and effects of expressing different forms of human METCAM/MUC18 on angiogenesis and tumor formation compared. The effect of expressing different forms of METCAM/MUC18 in LNCaP cells on the level of VEGF protein and the micro-vessel density in the in vivo tumors were determined. Results. LNCaP clones/cells overly expressing the wild type or various cytoplasmic tail-deleted METCAM/MUC18 proteins had a higher tumor-take rate (80-100%) than the cells expressing vectors (50%). LNCaP clones/cells that overly expressed the cytoplasmic tail-deleted METCAM/MUC18 proteins appeared to have larger tumors than those that overly expressed the wild type protein. The tumors formed by the LNCaP clones/cells that overly expressed a soluble METCAM/MUC18 protein, in which both the cytoplasmic tail and the transmembrane domain were deleted, were not enriched with and not engulfed by massive blood vessels, whereas the tumors formed by the LNCaP cells that overly expressed the wild type or the cytoplasmic tail-deleted METCAM/MUC18 protein were enriched with and engulfed by massive blood vessels. Majority of the tumors formed by an equal mixture of the LNCaP cells, which expressed the wild type, and the cells, which expressed the soluble METCAM/MUC18, were not enriched with and not engulfed by massive blood vessels. The VEGF level and the micro-vessel density in the tumors formed by LNCaP clones/cells that overly expressed the wild type or the cytoplasmic tail-deleted METCAM/MUC18 proteins were at least 2 fold higher than those in the tumors formed by the LNCaP clone/cells that overly expressed a soluble METCAM/MUC18 protein. Conclusions. The ectodomain of the METCAM/MUC18 protein is necessary and sufficient, but the cytoplasmic tail is dispensable and may be inhibitory for angiogenesis and tumorigenesis of human prostate cancer LNCaP cells in nude mice. We suggest that human METCAM/MUC18 increases tumorigenesis and initiates metastasis of LNCaP cells by inducing vascularization inside and outside of tumors and hence mediates the hematogenous spread of tumor cells. We also suggest that peptides derived from human METCAM/MUC18 protein may be useful for blocking tumorigenesis and metastasis of human prostate cancer cells.
Modern Conception of Retinal Detachment with its Relation to Internal Medicine
Authors: Clyde A. Clapp
Journal: Annals of Internal Medicine (1932)

Article1 April 1932Modern Conception of Retinal Detachment with its Relation to Internal MedicineCLYDE A. CLAPP, M.D.CLYDE A. CLAPP, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-5-10-1313 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptIt may seem to you that the question of detachment of the retina is rather a special subject to bring before a group of internists but in recent years there has been a new conception as to the etiology of one type of this condition, and a new line of therapy has been developed. This new conception of etiology and therapy as well as our frequent call upon the internists for help in diagnosis of the cause of these conditions warrants our consideration of this subject.As you all know the retina is very loosely attached to the underlying tissue... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Baltimore, Maryland*Presented at the clinical session of the Baltimore Meeting of the American College of Physicians, March 24, 1931, at the Wilmer Clinic. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 April 1932Volume 5, Issue 10Page: 1313-1314KeywordsEtiologyRetinaRetinal detachment ePublished: 1 December 2008 Issue Published: 1 April 1932 PDF downloadLoading ...
Just Beyond the Next Bend in the River: Reflections on a Medical Career
Authors: Lockhart B. McGuire
Journal: Annals of Internal Medicine (1991)

On Being a Doctor1 January 1991Just Beyond the Next Bend in the River: Reflections on a Medical CareerLockhart B. McGuire, MDLockhart B. McGuire, MDSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-114-1-83 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptVignettes or anecdotes often lack the authority of objective, analytic forms of writing. Nevertheless, we physicians sometimes feel compelled to offer these kinds of stories from our experience. Although medical vignettes may not illustrate general principles, they often contain glimpses of truth, unexpected combinations of human frailty and strength, and interesting blends of irony and idealism. Their message is one of a pervasive particularity and unpredictability in a world that looks to science for predictability and control.As Sir William Osler observed, "To practice medicine on patients without the study of books is to sail an uncharted sea, but to... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: Lockhart B. McGuire, MD†Dr. McGuire died on 29 April 1990. After Dr. McGuire's death, Marcia Day Finney assumed the responsibility of editing the manuscript for publication. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byAn Elephant SwimmingWard Casscells, MDThe State of Internal MedicineGregg Coodley, MD, Marcia Kerensky Coodley, MD 1 January 1991Volume 114, Issue 1 Page: 83-87 Keywords Frailty Rivers ePublished: 1 December 2008 Issue Published: 1 January 1991 Copyright & Permissions© 1991 American College of PhysiciansPDF downloadLoading ...
Idiopathic Thrombopenic Purpura
Authors: Erastus I. Guller, John S. Lawrence
Journal: Annals of Internal Medicine (1931)

Article1 June 1931Idiopathic Thrombopenic PurpuraERASTUS I. GULLER, JOHN S. LAWRENCEERASTUS I. GULLERSearch for more papers by this author, JOHN S. LAWRENCESearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-4-12-1535 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe symptom-complex of idiopathic thrombopenic purpura is too well known to justify the reporting of additional patients with this disease. Atypical forms of this disorder are recognized but they have received much less attention. Accordingly it has seemed justifiable to report the five cases occurring in this paper since their data illustrate some of the atypical forms of this condition. These patients demonstrate how difficult it may be in some instances to distinguish aplastic anemia from idiopathic thrombopenic purpura. They further emphasize the fact that a marked leucopenia may be an associated finding in some of the patients with this...Bibliography1 CHRISTIAN HA: The Oxford Medicine (Oxford University Press). II: 779. Google Scholar2 ISAACSDANIELIAN RAC: Maintenance of leukocyte level and changes during irradiation. A study of the white blood corpuscles appearing in the saliva and their relation to those in the blood. Am. J. M. Sc., 1927, 174:70. CrossrefGoogle Scholar3 KAZNELSON P: Verschwinden der hämorrhagischen Diathese bei einem Falle von "essentieller Thrombopenie" (Frank) nach Milzexstirpation, Splenogene thrombolytische Purpura. Wien. klin. Wchnschr., 1916, 29:1451. Google Scholar4 MINOT GR: Diminished blood platelets and marrow insufficiency. A classification and differential diagnosis of purpura hemorrhagica, aplastic anemia, and allied conditions. Arch. Int. Med., 1917, 19:1062. CrossrefGoogle Scholar5 MINOTBUCKMAN GRTE: A Text-book of Medicine edited by Russell L. Cecil. (W. B. Saunders and Co.) 1930, page 993. Google Scholar6 SHOUSEWARRENWHIPPLE SSLGH: Aplasia of marrow and fatal intoxication in dogs produced by roentgen irradiation of all bones. In Press, J. Exper. Med. Google Scholar7 WHIPPLEROBSCHEIT-ROBBINSWALDEN GHFSGB: Blood regeneration in severe anemia. XXI. A liver fraction potent in anemia due to hemorrhage. Am. J. M. Sc. 1930, 179:628. CrossrefGoogle Scholar8 WRIGHT JH: The histogenesis of the blood platelets. J. Morphol., 1910, 21:263. CrossrefGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: ERASTUS I. GULLER; JOHN S. LAWRENCEAffiliations: Rochester, N. Y.*From the Department of Medicine, University of Rochester, School of Medicine, and the Medical Clinic of the Strong Memorial Hospital and Rochester Municipal Hospital. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 June 1931Volume 4, Issue 12 Page: 1535-1544 Keywords Aplastic anemia Hospital medicine ePublished: 1 December 2008 Issue Published: 1 June 1931 PDF downloadLoading ...
The Diagnosis of Immediate Type Allergy to Cladosporium herbarum.
Authors: L. Aukrust, K. Aas
Journal: Allergy (1978)

The radioallergosorbent test (RAST) was used to demonstrate IgE. Antibodies to Cladosporium herbarum in 35 children. Freeze‐dried samples of Cladosporion herbarum were obtained from two commercial producers, extracted and used for the preparation of two RAST disc series which were Compared with the commercially available Phadebas Cladosporium herbarum discs. Marked qualitative differences were found.
Enabling Students to Deal With the DisabledOperation Smile Volunteers Travel Far to Transform LivesTest for Diabetic Tendency May Aid Risk Factor StudiesQuality Groups CoordinateEnabling Students to Deal With the DisabledOperation Smile Volunteers Travel Far to Transform LivesTest for Diabetic Tendency May Aid Risk Factor StudiesQuality Groups Coordinate
Authors: M Mitka
Journal: JAMA (1999)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Local vs Central Institutional Review Boards for Multicenter Studies
Authors: Carlos D Rosé
Journal: JAMA (2003)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Phenformin-Related Lactic Acidosis in a Thirty-Year-Old Man
Authors: S A Blumenthal, D H Streeten
Journal: Annals of Internal Medicine (1976)

Letters1 January 1976Phenformin-Related Lactic Acidosis in a Thirty-Year-Old ManSTANLEY A. BLUMENTHAL, M.D., F.A.C.P., DAVID H. P. STREETEN, M.B., D.PHIL., F.R.C.P.STANLEY A. BLUMENTHAL, M.D., F.A.C.P.Search for more papers by this author, DAVID H. P. STREETEN, M.B., D.PHIL., F.R.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-84-1-55_2 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptWe wish to report a case that underscores the conclusions of Williams and Palmer in their recent editorial (Ann Intern Med 83:567-568, 1975). The patient, whose case account follows, is to our knowledge the youngest patient with phenformin-related lactic acidosis yet reported.A 30-year-old white man with a 3-year history of diabetes entered State University Hospital on 4 June 1974. During the preceding year, he took 250 mg of DBI-TD*per day in divided doses. He worked long hours in a gas station and was well until 6 days before admission, when he developed mild fever and cervical adenopathy. A...References1. JANGAARDPEREIRAPINSON NJR: Metabolic effects of the biguanides and possible mechanism of action. Diabetes 17:96-104, 1968 CrossrefMedlineGoogle Scholar2. MUNTONI S: Inhibition of fatty acid oxidation by biguanides: implications for metabolic physiopathology. Adv Lipid Res 12:311-377, 1974 CrossrefMedlineGoogle Scholar3. GORDONDEHARTOG EM: Gluconeogenesis in renal cortical tubules-effect of phenformin. Diabetes 22:50-57, 1973 CrossrefMedlineGoogle Scholar4. OLIVA P: Lactic acidosis. Am J Med 48:209-225, 1970 CrossrefMedlineGoogle Scholar5. WAHRENHAGENFELDTFELIG JLP: Splanchnic and leg exchange of glucose, amino acids, and free fatty acids during exercise in diabetes mellitus. J Clin Invest 55:1303-1314, 1975 CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Endocrinology Section Veterans Administration Hospital Department of Medicine State University of New York Upstate Medical Center Syracuse, New York 13210*Time-disintegration phenformin hydrochloride capsules, 50 mg/capsule; Geigy Phamaceuticals, Ardsley, New York. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byPhenformin in Diabetes MellitusLUBOMIR J. VALENTA, M.D. 1 January 1976Volume 84, Issue 1Page: 55-56KeywordsFeversLactic acidosis Issue Published: 1 January 1976 PDF downloadLoading ...
Abstract MP08: Bundle Branch Blocks and Risk of Mortality in the Atherosclerosis Risk in Communities Study: Gender and Racial Differences
Authors: Zhu-ming Zhang, Pentti M Rautaharju, Ronald J Prineas, Laura Loehr, Wayne Rosamond, Elsayed Z Soliman
Journal: Circulation (2014)

Introduction: Gender and racial differences in the association between different patterns of bundle branch block (BBB) and mortality in the general population are not well established. Methods: We used Cox proportional hazard models to evaluate the risk of all-cause mortality associated with left BBB (LBBB) and right BBB (RBBB). The study group, 15,316 participants from the Atherosclerosis Risk in Communities (ARIC) study was stratified by gender and race. We excluded the participants with other BBBs or QRS duration ≥120 ms not classified as complete RBBB or LBBB. Results: At baseline in 1987-89, mean age was 54 years, 55.3% were women, and 26.8% blacks. There were 88 LBBB and 202 RBBB. During a mean follow up of 18 years, 3,347 deaths occurred. Compared to No-BBB, LBBB was strongly associated with increased mortality in all subgroups by gender and race (Table). However, RBBB was not significantly associated with all-cause mortality in any of the subgroups in the multivariable adjusted models. Conclusions: Prevalent LBBB, but not RBBB, is a predictor of all-cause mortality in women and men as well as in blacks and whites. These findings may help in selecting patients who could benefit from further diagnostic evaluation for possible therapeutic and preventive intervention.
The Science of Quality Improvement
Authors: Eddy Fan, Dale M. Needham
Journal: JAMA (2008)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
ANALYSIS OF AN EPIDEMIC OF DENGUE FEVER
Authors: Paul Kisner, E. T. Lisansky
Journal: Annals of Internal Medicine (1944)

Article1 January 1944ANALYSIS OF AN EPIDEMIC OF DENGUE FEVERPAUL KISNER, E. T. LISANSKYPAUL KISNERSearch for more papers by this author, E. T. LISANSKYSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-20-1-41 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe following paper attempts an analysis of 318 cases of dengue fever. The authors wish to emphasize that in this area there was no possible recourse to literature on this subject other than that contained in a few available standard textbooks. Approximately 1200 cases of dengue fever occurred in army personnel in and around a coastal town on an island in the South Pacific from March 1, 1943 to April 30, 1943. At the present time, May 10, 1943, there is evidence of a minimal degree of subsidence in this epidemic. The incidence in the total army command on this...Bibliography1. STRONG RP: Stitt's diagnosis, prevention and treatment of tropical diseases, Sixth Edition, Vol. II, 1942, The Blakiston Company, Philadelphia. Google Scholar2. DUNHAM GC: Military preventive medicine, U. S. Army Med. Bull. No. 23, Third Edition, 1938. The Book Shop, Medical Field Service School, Carlisle Barracks, New York. Google Scholar3. MAXWELL E Personal communication from , M.C. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: *Received for publication August 11, 1943. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byDengue and US Military Operations from Spanish–American War through TodayDenguefieberDenguefieberA HÆMORRHAGIC FEVER IN SINGAPOREAN EPIDEMIC OF DENGUE–LIKE FEVER, TOWNSVILLE, 1954: CLINICAL FEATURES, WITH A REVIEW OF THE LITERATURETropische ViruskrankheitenTropische Viruskrankheiten 1 January 1944Volume 20, Issue 1Page: 41-51KeywordsArmed forcesDengue fever ePublished: 1 December 2008 Issue Published: 1 January 1944 PDF downloadLoading ...