tbuckley/cabot-search huggingface dataset:
Abstract 15015: Prognostic Implication of Anemia on Clinical Outcomes After Percutaneous Coronary Intervention with Drug-Eluting Stent
Authors: Sung Won Cho, Duk-Woo Park, Yong-Giun Kim, Gyung-Min Park, Ki Won Hwang, Chang Hee Kwon, Jeong Yoon Jang, Suk-Won Choi, Hae-Geun Song, Jung-Min Ahn, Won-Jang Kim, Jong-Young Lee, Soo-Jin Kang, Seung-Whan Lee, Young-Hak Kim, Cheol Whan Lee, Seong-Wook Park, Seung-Jung Park
Journal: Circulation (2011)

Background Anemia has been shown to be an independent predictor of long-term outcomes after percutaneous coronary intervention (PCI). The purpose of this study was to assess the impact of anemia on...
Abstract 1817: Chronic Treatment with Resveratrol Restores Serca 2a Expression and Improves Cardiac Function of Diabetic Mice
Authors: Madhu Gupta, Mohamed Sulaiman, Muthu Periasamy, Andrew J Griffin, Mahesh P Gupta
Journal: Circulation (2008)

Background: Diabetic cardiomyopathy is characterized by impaired cardiac contractility. An important contributor to diastolic dysfunction in the diabetic heart is the reduced activity of sarcoplasmic reticulum calcium pump (SERCA2a). Over expression of SERCA2a alone in transgenic mice protected diabetic hearts from severe contractile dysfunction. Resveratrol (RSV) is a phytoalexin, present in dietary supplements and found naturally in red grape skin and red wine. It shows a multitude of cardio protective effects including anti-hypertrophic, anti-oxidant, anti-ischemic and antiarrythmic. Its role in diabetic cardiomyopathy has not been evaluated. Objectives: We tested the hypothesis that chronic treatment with RSV improves contractile function of the diabetic heart by enhancing SERCA2a expression involving transcriptional regulatory mechanisms. Methods and Results: Adult CD 1 mice were injected with streptozotocin (150 mg / kg i.p.). Mice with more than 400 mg /dL blood glucose levels were considered diabetic, vehicle injected animals served as controls. Half of the diabetic animals were fed RSV enriched diet (0.067%). After three months, by echocardiography diabetic animals showed increased LVESD (38%), increased LVEDD (22%), and reduced fractional shortening (46%). This was accompanied by reduced SERCA2a and SIRT1 protein expression as well as a 3-fold decline in SERCA2a mRNA as assessed by real-time PCR. RSV treatment improved LV function and SERCA2a mRNA to almost normal levels. In primary cultures of cardiomyocytes, transient transfection analysis of SERCA2a promoter / CAT reporter construct (consisting of 1.5 Kb SERCA2a promoter region) revealed a 4-fold decline in SERCA2a promoter activity when cells were grown in high glucose (33 mM) for 5 days as compared to cells grown in normal glucose (5.5 mM) for a comparable period of time. The decline in reporter expression was prevented by pretreatment with RSV ( 0.5 uM). Conclusions and Implications: Our results indicate that in diabetic hearts, resveratrol improves cardiac function by enhancing SERCA2a expression. This effect is mediated at the transcription level possibly involving SIRT1 activiity.
Abstract 463: Hypoxia is a Primary Stimulus for Up-Regulation of the Apelin-APJ Cardio-Regulatory Pathway
Authors: Ahmad Y Sheikh, Hyung J Chun, Ramendra K Kundu, Andrew J Connolly, Diego Ardigo, Stephen L Hendry, Sonja Schrepfer, Georges Degenfeld, Alexander J Glassford, Roger A Wagner, Philip S Tsao, Marc P Pelletier, Robert C Robbins, Thomas Quertermous
Journal: Circulation (2006)
Abstract 10802: Differential Effects of Everolimus on Early vs. Late Allograft Vasculopathy Progression in Heart Transplant Recipients: a Longitudinal IVUS-Based Study
Authors: Luciano Potena, Marco Masetti, Marianna Nardozza, Paola Prestinenzi, Nevio Taglieri, Gaia Magnani, Francesco Saia, Paolo Romani, Francesco Barberini, Fabio Coccolo, Francesco Fallani, Antonio Russo, Francesco Grigioni, Angelo Branzi
Journal: Circulation (2011)

Coronary allograft vasculopathy (CAV) is the main cause of graft failure after heart transplantation (HT). Clinical trials showed that everolimus (EVE) prevents early CAV. However, its effect in a ...
Abstract 17546: No Decrease in the Incidence of Heart Failure Following Acute Myocardial Infarction in the Years 1994-2006
Authors: William J Kostis, Yingzi Deng, Abel E Moreyra, John S Pantazopoulos, John B Kostis
Journal: Circulation (2011)

Objectives: Heart failure (HF) is a common serious complication following acute myocardial infarction (MI). We studied whether improvements in MI treatment had an impact on the incidence of post-MI HF. Methods: We used data from the Myocardial Infarction Data Acquisition System (MIDAS) database, selecting all first myocardial infarctions admitted to non-federal hospitals in the state of New Jersey between 1994 and 2006. We studied the incidence of HF during admission, within 28 days of admission, and 28 days to one year from admission. Using a multivariate model, we assessed which clinical characteristics had an impact on the incidence of HF. Results: A total of 185,483 patients were admitted with a first MI. The incidence of HF within one year was 38.2% in 1994 and remained stable through 2006 (range 37.6% - 41.0%). The incidence of HF in patients with subendocardial MI was also stable and significantly higher than that observed in transmural MI (43.7% vs. 30.9%, p&lt;0.0001). However, among patients with transmural MI, HF incidence within one year declined from 32.8% in 1994 to 26.3% in 2006 (p&lt;0.0001), mainly due to a decline in HF during the index admission. HF incidence after discharge remained stable in transmural MI and increased in subendocardial MI. By multivariate modeling, older age, female gender, black race, diabetes, atrial fibrillation, renal disease, and chronic obstructive pulmonary disease were associated with higher incidence of HF (p&lt;0.0001 for all). Patient age and the rates of diabetes, hypertension, renal disease, cancer, and anemia increased during the period of observation (p&lt;0.0001). Conclusions: Despite major advances in management of acute myocardial MI, the incidence of post-MI HF remained stable. The only decline observed was in HF during an index admission for transmural MI. Subendocardial MI was associated with a higher HF incidence. These findings may be due to the increasing age and rates of comborbidities among patients with first MI.
Abstract 14294: Microvascular Resistance Index Immediately after Primary Percutaneous Coronary Intervention Predicts the Presence of Microvascular Obstruction in Patients With ST-elevation Acute Myocardial Infarction Achieving TIMI Grade 3 Reperfusion
Authors: Hironori Kitabata, Kenichi Komukai, Kohei Ishibashi, Takashi Tanimoto, Yasushi Ino, Keizo Kimura, Kumiko Hirata, Masato Mizukoshi, Toshio Imanishi, Takashi Akasaka
Journal: Circulation (2010)

Background:  It has been reported that the presence of microvascular obstruction (MVO) after acute myocardial infarction (AMI) is associated with larger infarct size, poorer clinical outcomes, and worse left ventricle remodeling. Contrast-enhanced magnetic resonance imaging (Ce-MRI) allows us to detect microvascular damage with the transmural extent of infarction. A dual-sensor (pressure and Doppler velocity) guidewire has an ability to evaluate microvascular damage quantitatively. We sought to investigate whether MVRI immediately after successful primary percutaneous coronary intervention (PCI) can predict the presence of MVO in patients with anterior AMI.   Methods:  In 25 patients with TIMI grade 3 flow after primary PCI for a first anterior AMI, using a dual-sensor guidewire, MVRI was calculated as the ratio of mean distal pressure to average peak flow velocity during maximal hyperemia. With Ce-MRI, MVO was defined as hypodense regions within the hyperenhanced infarcted area. Myocardial necrosis was defined as transmural MI when delayed enhancement was extended to >75% of the thickness of at least 2 contiguous LV segments. According to the presence/absence of MVO, patients were divided into two groups (MVO group; n = 8, No-MVO group; n = 17).   Results:  MVRI was strongly correlated with peak creatine kinase (CK)-MB (r = 0.657, p = 0.0003) and infarct size by MRI (r = 0.789, p  −1 •s vs. 2.21 ± 0.85 mmHg•cm −1 •s, p = 0.018). Moreover, the incidence of transmural MI was higher in the MVO group (62% vs. 12%, p  −1 •s (sensitivity 63%, specificity 89%).   Conclusions:  MVRI immediately after primary PCI is a useful predictor for the presence of MVO in patients with reperfused MI. Our findings may suggest that in patients with high microvascular resistance, it is necessary to think about the adjunctive pharmacologic strategies for microvascular protection such as nicorandil to primary PCI.
Abstract 20151: Hyperlipidemia Increases Microparticle Tissue Factor and the Activation of Coagulation: A Tale of Mice and Monkeys
Authors: A. Phillip Owens, Ryan E Temel, D. Anthony Barcel, Stephanie M. Marshall, Allison L. McDaniel, Nigel Mackman
Journal: Circulation (2010)

Objective: Oxidized lipids induce tissue factor (TF) expression in monocytes. We previously demonstrated that prolonged hyperlipidemia in mice increased microparticle (MP) TF activity (7.4 fold, P ...
Abstract 12157: HDAC-Dependent Regulation of Pathological Hypertrophy
Authors: Cyndi R Morales, Zully Pedrozo, Dan L Li, Herman I May, Nan Jiang, Sergio Lavandero, Thomas G Gillette, Joseph A Hill
Journal: Circulation (2013)

Introduction: Histone deacetylases (HDACs) participate in pathological cardiac growth and failure, and small molecule inhibitors of HDACs slow, and even regress, pathological hypertrophy. mTOR (mam...
BACTERIUM COLI COMMUNE.
Authors: Dirk Snoeck Henkemans
Journal: JAMA (1892)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Journals JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2024 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
局部麻醉下痔上动脉“8”字形缝扎黏膜悬吊术治疗内痔56例临床分析
Authors: 孙学军, 迟慧, 韩刚
Journal: BMJ (2008)

随着人们对痔发生机制的新认识,痔的手术方式也发生了演变[1].我院自2005年6月至2006年12月,采用局部麻醉下痔上动脉8字形缝扎悬吊术治疗Ⅱ、Ⅲ度内痔56例,取得了满意效果,现报告如下。
Abstract 21442: Determinants of Bare Metal Stent Use in Patients with ST-Elevation Myocardial Infarction Undergoing Primary Percutaneous Cronary Intervention
Authors: Puja B Parikh, Allen Jeremias, Srihari S Naidu, Richard A Shlofmitz, Sorin J Brener, Thomas Pappas, Kevin P Marzo, David L Brown, Luis Gruberg
Journal: Circulation (2010)

Introduction: Bare metal stent (BMS) use in patients with ST-elevation myocardial infarction (STEMI) undergoing primary percutaneous coronary intervention (PCI) has been associated with higher rate...
Diffuse disorder of coronary artery vasomotility in patients with coronary spastic angina
Authors: Ken Okumura, Hirofumi Yasue, Kozaburo Matsuyama, Hisao Ogawa, Kiyotaka Kugiyama, Hiroshi Ishizaka, Hitoshi Sumida, Hiromi Fujii, Toshiro Matsunaga, Ryusuke Tsunoda
Journal: Journal of the American College of Cardiology (1996)
Abstract 1427: Pathogenesis of Hypertrophic Cardiomyopathy Caused by the Myozenin 2 Mutations Involves Calcineurin-Dependent and -Independent Mechanisms
Authors: Suet Nee Chen, Raffaella Lombardi, Gabriela Rodriguez, Ali J Marian
Journal: Circulation (2008)

Identification of myozenin-2 mutations (MYOZ2) has expanded the spectrum of causal mutations for hypertrophic cardiomyopathy (HCM) to include the Z disk proteins. The molecular mechanism(s) by which MYOZ2 mutations cause HCM are unknown. MYOZ2 is known to inhibit calcineurin phosphatase (PP2B). We posit mutant MYOZ2 lose their inhibitory effects on PP2B and hence, the ensuing cardiac phenotype results from enhanced activity of PP2B. To test this hypothesis, we generated lines of transgenic mice expressing either N-terminally flag-tagged wild type (MYOZ2-WT) or mutant MYOZ2-P48 or MYOZ2-M246 regulated by the α-myosin heavy chain promoter. Expression levels of the transgenic and endogenous MYOZ2 proteins were detected by immunoblotting using pan-specific anti-MYOZ2 and anti-Flag antibodies. The transgene proteins constituted 15 to 35% of the total MYOZ2 protein. The total MYOZ2 levels remained unchanged. Immunofluorescence staining showed both WT and mutant MYOZ2 proteins were incorporated into the Z disks. To determine the effects of the WT and mutant MYOZ2 proteins on PP2B activity, we measured PP2B phosphatase and Nuclear Factor of Activated T Cells (NFATc), a downstream target of PP2B, activities in myocardial protein extracts by ELISA-based assays. Expression of MYOZ2-WT reduced PP2B phosphatase and NFAT activities by ~90% and 20%, respectively while equal levels of expression of the mutant MYOZ2 reduced these activities by ~ 50% and 10%, respectively, i.e., a 2-fold reduction in inhibitory effect of the mutant as compared to WT. The mutant MYOZ2-P48 and MYOZ2-M246 showed increased mortality, cardiac hypertrophy, preserved cardiac systolic function, increased myocytes size and interstitial fibrosis. The MYOZ2-WT mice also exhibited cardiac hypertrophy and interstitial fibrosis. Thus, the mutation impart a loss of function effect on MYOZ2, suggesting a possible gain of function of PP2B in humans with with autosomal dominant HCM. However, excess inhibition of PP2B in the heart, as observed in the MYOZ2-WT mice, also led to cardiac hypertrophy and fibrosis. Thus both excess inhibition as well as relative enhancement of PP2B activity in the heart could cause cardiac hypertrophy and fibrosis.
Abstract 11039: Impact of Mitral Regurgitation on Post-Operative outcomes in Non Cardiac Surgeries
Authors: Navkaranbir S Bajaj, Shikhar Agarwal, E M Tuzcu, Anitha Rajamanickam, Theodore Catacutan, Samir Kapadia
Journal: Circulation (2011)

Introduction: The preoperative cardiac risk assessment scoring systems traditionally do not include valvular regurgitation as a criterion for adverse outcome prediction. We performed this study to ...
The roles of psychiatrists in organized outpatient mental health settings
Authors: M Olfson, G L Klerman, H A Pincus
Journal: American Journal of Psychiatry (1993)

This paper describes the clinical roles of psychiatrists in U.S. organized outpatient mental health settings.Data were analyzed from the 1986 National Institute of Mental Health Client/Patient Sample Survey. The authors determined the range, volume, and content of services provided to established outpatients treated by psychiatrists at six types of mental health organizations: state and county mental hospital clinics, general hospital mental health clinics, private psychiatric hospital clinics, U.S. Department of Veterans Affairs medical center mental health clinics, free-standing mental health clinics, and multiservice mental health organizations.The psychiatrists treated nearly one-half (48.2%) of the established outpatients in organized settings, more than any other discipline. Most of the psychiatrists' patients (68.3%) were also treated by other mental health professionals. Psychiatrists treated a greater proportion of the patients at hospital-based clinics (60.7%) than at clinics without hospital affiliations (43.6%). They also treated larger proportions of the patients with schizophrenia (77.9%), affective disorders (50.6%), or anxiety disorders (59.2%) than those with adjustment disorders (23.7%), substance use disorders (34.3%), or childhood mental disorders (29.5%). The patients treated by psychiatrists commonly received psychotropic medications (77.3%) and individual therapy (66.3%) but less commonly received group (20.7%), skills (11.9%), or family (5.9%) therapy.In organized outpatient settings, psychiatrists typically work with other mental health professionals to treat a select group of severely ill patients. However, there is considerable variation in the extent to which different types of mental health organizations rely on psychiatrists to provide clinical care.
Abstract 9943: Prevention and Reversal of Hypertrophy Through a Novel Drug-Like Compound That Inhibits Local Calcium Oscillations in a Pmca4/calcineurin Microdomain
Authors: Tamer M Mohamed, Delvac Oceandy, Riham Abou-Leisa, Min Zi, Sukhpal prehar, Florence Baudoin-Stanley, Elizabeth J Cartwright, Ludwig Neyses
Journal: Circulation (2011)

In pathological hypertrophy, the calcium/calmodulin dependent phosphatase calcineurin has been shown to transmit upstream calcium signals through dephosphorylation of the transcription factor NFAT which subsequently translocates to the nucleus and initiates a hypertrophic gene programme. We have previously shown that plasma membrane calcium ATPase isoform 4 (PMCA4) binds to calcineurin when overexpressed in HEK293 cells. We here investigated whether targeting PMCA4 by genetic or pharmacological strategies provides novel opportunities for the reduction of cardiac hypertrophy through modulation of calcineurin. Germline PMCA4 ablation resulted in the attenuation of pathological hypertrophy in response to pressure overload (Heart weight /tibia length ratio after transverse aortic constriction (TAC), PMCA4-/-: 6.74 ± 0.33 mg/mm vs WT: 8.34 ± 0.88 mg/mm, P10). Mechanistically, PMCA4 ablation led to a significant reduction in calcineurin at the sarcolemma as shown by Western blot and electron microscopy. We then developed a specific pharmacological inhibitor of PMCA4, which had not previously been available. Using a modified colorimetric ATPase assay we screened a library of medically optimized drug-like molecules and identified AP2 which has an IC50 of 150 nM for PMCA4. Injection of AP2 in mice (5 mg/kg body weight/day ip) significantly reduced cardiac hypertrophy following TAC for 2 weeks by 50% (n=10 each group, p&lt;0.01). Moreover, AP2 reversed pre-established TAC-induced hypertrophy (HW/TL (mg/mm): sham, 5.7+0.3, TAC+vehicle, 9.1+0.7, TAC+AP2, 7.6+0.6, n=4-6 each group, P&lt;0.05). Using a novel fluorescent Ca2+ sensor (GCaMP2) attached to the N-terminus of PMCA4 we found that AP2 reduced calcium oscillations in the microdomain around PMCA4 by 45% leading to reduced calcineurin activation. Furthermore, AP2 inhibited the NFAT pathway as shown by expression of the bona fide calcineurin target RCAN 1.4 and NFAT phosphorylation levels. Overall, our results demonstrated that specific inhibition of PMCA4 prevents and reverses pressure-overload hypertrophy, likely through regulation of local calcium oscillations around calcineurin making the plasma membrane calcium pump a potential target for the treatment of cardiac hypertrophy.
谵妄、抑郁、焦虑的识别和处理
Authors: 姜荣环, 甘一方
Journal: BMJ (2009)

慢性躯体疾病如高血压、糖尿病等已经纳入全科医师的社区慢性非传染性疾病(慢病)管理,这些躯体疾病常伴发或继发精神障碍,而精神障碍对躯体疾病的转归有重要的影响.因此,识别和处理常见的躯体疾病伴发或继发精神障碍对于社区卫生服务具有重要的意义。
Abstract 81: How Rapidly Can People find an AED?
Authors: Hiroshi Kaneko, Tetsuo Hatanaka, Aki Nagase, Hiroko Noguchi, Atsuko Nagatani, Seishiro Marukawa
Journal: Circulation (2007)

Success of public defibrillation program (PAD) depends in part on the rapidity for lay people to find an AED. The aim of the present study was to investigate how rapidly lay people can find an AED ...
Abstract 14941: External Validation of a Risk Score to Predict Appropriate Implantable Cardioverter Defibrillator Therapy for Primary Prevention in Tetralogy of Fallot
Authors: Zeliha Koyak, Joris R De Groot, Berto J Bouma, Isabelle C Van Gelder, Werner Budts, Lieselot Van Erven, Pascal F Van Dessel, Arie J Van Dijk, Arthur A Wilde, Petronella G Pieper, Barbara J Mulder
Journal: Circulation (2011)

Background Previously, a risk score by Khairy and colleagues was developed to predict appropriate implantable cardioverter defibrillator (ICD) therapy for primary prevention of sudden cardiac death...
Abstract 12064: Low Income, Regardless of Education Level, is a Significant Independent Predictor of Incident Heart Failure in Community-Dwelling, Medicare-Eligible Older Adults
Authors: Amiya A Ahmed, Yan Zhang, Robert C Bourge, Meredith L Kilgore, Beverly Williams, Patricia Sawyer, Inmaculada B Aban, Gregg C Fonarow, Ali Ahmed
Journal: Circulation (2011)

Background: Prior studies (PMID: 21147865 and 10378616) have reported variable associations between low education and incident heart failure (HF). Further, to what extent this association is mediat...
Abstract 9424: Low In-Treatment HDL Cholesterol Levels Strongly Predict the Development of New Diabetes Mellitus: The LIFE Study
Authors: Peter M Okin, Benedicte P Wiik, Darcy A Hille, Kristian Wachtell, Sverre E Kjeldsen, Lars A Lindholm, Bjorn Dahlof, Richard B Devereux
Journal: Circulation (2010)
Abstract 15036: Resolution Of Inflammation Determines Short- And Longterm Prognosis In Myocarditis - data From Esetcid
Authors: Bernhard Maisch, Susanne Koelsch, Guenther Hufnagel, Reinhard C Funck, Volker Ruppert, Sabine Pankuweit
Journal: Circulation (2011)

Treatment of inflammatory dilated Cardiomyopathy (iDCM) beyond heart failure treatment is a matter of controversy. The TIMIC study demonstrated hemodynamic and clinical benefit in acute myocarditis...
Abstract 17977: Mir-133 Transfection in Mscs Downregulates Critical Pro-Apoptotic Genes in the Infarct Heart and Improves Cardiac Function
Authors: Mahmood Khan, Sarath Meduru, Angela Bryant, Mickey Martin, Periannan Kuppusamy, Terry S Elton
Journal: Circulation (2011)

Cell-based therapy (cardiomyoplasty) is one of the most promising techniques for repair and regeneration of the infarcted myocardium. Mesenchymal stem cells (MSCs) are pluripotent, adult stem cells that are easily expanded in culture, and can differentiate into numerous lineages, including vascular endothelial cells and cardiomyocytes. Unfortunately, a major impediment to the improvement of cardiac function following stem cell transplantation has been survival of the cells in the infarct myocardium due to the severely hypoxic nature of this tissue. The lack of oxygen and nutrients ultimately leads to apoptosis of the majority of the transplanted stem cells, thereby limiting engraftment and the chance of favorable outcome. microRNAs (miRNAs) are major post-transcriptional regulatory molecules that mainly suppress protein translation through binding their 3’UTR. microRNA-133a (miR-133a) is highly downregulated in hypertrophy and congestive heart failure in patients and in our animal model of myocardial infarction (MI). We found that transfecting MSCs with miR-133a decreases hypoxia-reoxygenation (6h of hypoxia, 12h reoxygenation) induced cell death and improves survival of MSCs. Similarly, transplantation of miR-133a transfected MSCs in rat (Fisher-344) hearts subjected to myocardial infarction (MI) by temporarily ligating the left coronary artery (LAD) and release, there was a significant improvement in cardiac function and decreased fibrosis when compared with MSC or MI groups. In addition, we performed a 96-well PCR array for apoptosis-related genes. The results from PCR array showed a 3-fold downregulation of ABL1 (c-abl oncogene 1, non-receptor tyrosine kinase) and BFAR (Bifunctional apoptosis regulator genes) in miR-133+MSCs as compared with the untreated MI group. This study demonstrated for the first time that the combination of miR-133a mimics along with MSCs improves cardiac function, decreases fibrosis and pro-apoptotic ABL1 and BFAR genes in the infarcted heart.