THE TREATMENT OF POLYCYTHEMIA VERA WITH RADIOACTIVE PHOSPHORUS
Authors: B K WISEMAN, R J ROHN, B A BOURONCLE, W G MYERS
Journal: Annals of Internal Medicine (1951)

Article1 February 1951THE TREATMENT OF POLYCYTHEMIA VERA WITH RADIOACTIVE PHOSPHORUSBRUCE K. WISEMAN, M.D., F.A.C.P., ROBERT J. ROHN, M.D., BERTHA A. BOURONCLE, M.D., WILLIAM G. MYERS, M.D.BRUCE K. WISEMAN, M.D., F.A.C.P.Search for more papers by this author, ROBERT J. ROHN, M.D.Search for more papers by this author, BERTHA A. BOURONCLE, M.D.Search for more papers by this author, WILLIAM G. MYERS, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-34-2-311 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptPrior to 1941, polycythemia vera was treated in the hematology clinic at The Ohio State University, College of Medicine, by the conventional methods of venesection, x-radiation and induced hemolysis. None of these, employed either singly or in various combinations, was judged satisfactory from the viewpoint of either patient or physician, for the reasons summarized in table 1. When radioactive phosphorus (P32) was first made available to us in 1941†from the cyclotron of the Radiation Laboratory of the University of California at Berkeley, California, through the generosity of Dr. John H. Lawrence, it was decided, as our supplies permitted, to...Bibliography1. Wintrobe MM: Osler's chronic cyanotic polycythemia with splenomegaly, Bull. Johns Hopkins Hosp. 85: 75, 1949. Google Scholar2. Wiseman BK: Is leukemia a disease of the reticulo-endothelial system? Blood 3: 867, 1948. CrossrefMedlineGoogle Scholar3. ForknerScottWu CETFSC: Treatment of polycythemia vera (erythremia) with a solution of potassium arsenite, Arch. Int. Med. 51: 616, 1933. CrossrefGoogle Scholar4. 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ReinhardtMooreBierbaumMoore EHCVOSS: Radioactive phosphorus as a therapeutic agent, J. Lab. and Clin. Med. 31: 107, 1946. MedlineGoogle Scholar11. Lawrence JH: The control of polycythemia by marrow inhibition, J. A. M. A. 141: 13, 1949. CrossrefMedlineGoogle Scholar12. Jung K: Ueber einen Fall von Polycythämie mit Ausgang in Myeloblastenleukämie, Centralbl. f. Herz- u. Gefässkr. 7: 118-163, 1915. Google Scholar13. Dameshek W: Physiopathology and course of polycythemia vera as related to therapy, J. A. M. A. 142: 790, 1950. CrossrefMedlineGoogle Scholar14. TinneyHallGiffin WSBEHZ: The prognosis of polycythemia vera, Proc. Staff Meet., Mayo Clin. 18: 227, 1943. Google Scholar15. NormanAllen ILEV: The vascular complications of polycythemia, Am. Heart J. 13: 257, 1937. CrossrefGoogle Scholar16. Brues AM: Biological hazards and toxicity of radioactive isotopes, J. Clin. Investigation 28: 1289, 1949. CrossrefGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Columbus, Ohio*Received for publication June 12, 1950.From the Department of Medicine, College of Medicine, The Ohio State University, Columbus, Ohio.†By 1942 this supply of radiophosphorus was augmented and shortly thereafter replaced by the product of our own cyclotron. This cyclotron was donated by the late Julius F. Stone, and operated by the Department of Physics, Ohio State University furnishing material to us through the coöperation chiefly of Dr. M. L. Pool. Since late in 1946 our supply of this isotope has come from Oak Ridge, Tenn., through arrangement with the Atomic Energy Commission. This work was partially subsidized by grants from the Comly-Coleman fund. 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MEYER, M.D., F.A.C.P.Polycythemia VeraTHE USE OF RADIOACTIVE PHOSPHORUS IN THE THERAPY OF LEUKEMIA, POLYCYTHEMIA VERA AND LYMPHOMAS: A REPORT OF 10 YEARS' EXPERIENCE*ROBERT B. CHODOS, M.D., F.A.C.P., JOSEPH F. ROSS, M.D., F.A.C.P.The treatment of polycythemia veraFATAL POLYCYTHEMIA FOLLOWING PERNICIOUS ANEMIA TREATED WITH VITAMIN B12*CARL F. HINZ JR., M.D.The Use of Radioactive Isotopes in MedicinePOLYCYTHAEMIA VERA WITH MULTIPLE MYELOMASymposium on Radioactive Isotopes 1 February 1951Volume 34, Issue 2Page: 311-330KeywordsHematology and oncologyPhlebotomyPhosphorusPolycythemia veraResearch laboratories ePublished: 1 December 2008 Issue Published: 1 February 1951 Copyright & PermissionsCopyright, 1951, by The American College of PhysiciansPDF downloadLoading ...