tbuckley/cabot-search huggingface dataset:
Abstract P2-13-11: Multimodality perioperative analgesia with paravertebral nerve block and gabapentin reduces narcotic use and hospital length of stay in mastectomy patients
Authors: Zandra H Cheng, Vlad Frenk, Jennifer D Bishop, Theresa Bowling, Helen A Pass
Journal: Cancer Research (2015)

Abstract Postoperative pain control is the major determinant in hospital length of stay (LOS) in patients undergoing mastectomy. Using a multimodality approach for peri-operative analgesia (PA) with paravertebral nerve block (PVB)(regional anesthesia) as well as including pre- and postoperative oral gabapentin, we significantly reduced both LOS and narcotic usage (NU) when compared to PVB alone or conventional postoperative management (CPM) with on demand postoperative pain medications. A single institution, retrospective chart review of patients undergoing mastectomy from 2009 to 2014 was performed (n = 129; 84 bilateral, 45 unilateral) with a subset analysis performed on patients undergoing tissue expander (TE) reconstruction (n=86) or bilateral mastectomies (n=84). Patients were grouped by PA type (CPM, PVB by catheter infusion, and PVB with gabapentin (PVB+G)). Data were analyzed via using Student t-test and significance was defined as p&amp;lt;0.05. As seen in the table below, LOS and NU decreased with increasing multimodal PA approach. LOS was significantly decreased by PVB+G compared to CPM and PVB for all mastectomies, bilateral mastectomies, and mastectomies with tissue expander (TE) reconstruction. NU was significantly decreased by PVB+G compared to CPM and PVB for all mastectomies and bilateral mastectomies, and trended toward decreasing NU in TE reconstruction. All (n = 129)(1) CPM (n=51)(2) PVB (n=35)(3) PVB+G (n=53)p 1 vs 3; p 2 vs 3LOS (days)2.3 (0.84)2.1 (0.71)1.61 (0.54)&amp;lt;0.0001; &amp;lt;0.0005NU (mg)73 (42.9)52 (32.3)39 (25.3)&amp;lt;0.001; 0.04TE reconstruction (n=86)(1) CPM (n=25)(2) PVB (n=21)(3) PVB+G (n=40) LOS (days)2.2 (0.50)2.3 (0.63)1.61 (0.44)&amp;lt;0.001;&amp;lt;0.001NU (mg)86 (32.6)55 (34.4)43 (36.3)&amp;lt;0.001; 0.10Bilateral (n=84)(1) CPM (n=20)(2) PVB (n=24)(3) PVB+G (n=40) LOS (days)2.4 (0.7)2.2 (0.72)1.65 (0.52)&amp;lt;0.009;&amp;lt;0.001NU (mg)84 (37.4)58 (32.4)38 (24.5)&amp;lt;0.001;0.0066NU = narcotic use normalized to morphine sulfate We have found employing a multimodality approach to PA with the addition of the GABA analogue, gabapentin, to regional anesthesia via PVB catheter infusion significantly improves the postoperative course of patients undergoing mastectomy procedures by decreasing LOS and NU. Citation Format: Zandra H Cheng, Vlad Frenk, Jennifer D Bishop, Theresa Bowling, Helen A Pass. Multimodality perioperative analgesia with paravertebral nerve block and gabapentin reduces narcotic use and hospital length of stay in mastectomy patients [abstract]. In: Proceedings of the Thirty-Seventh Annual CTRC-AACR San Antonio Breast Cancer Symposium: 2014 Dec 9-13; San Antonio, TX. Philadelphia (PA): AACR; Cancer Res 2015;75(9 Suppl):Abstract nr P2-13-11.
Possible role of interleukin-17 in the pathogenesis of lichen planus
Authors: O. Shaker, A. S. Hassan
Journal: British Journal of Dermatology (2011)

Journal Article Possible role of interleukin‐17 in the pathogenesis of lichen planus Get access O. Shaker, O. Shaker Departments of Medical Biochemistry Search for other works by this author on: Oxford Academic Google Scholar A. S. Hassan A. S. Hassan Molecular Biology and Dermatology, Faculty of Medicine, Cairo University, Maadi, Cairo 0123, Egypt E‐mail: olfatshaker@yahoo.com Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 166, Issue 6, 1 June 2012, Pages 1367–1368, https://doi.org/10.1111/j.1365-2133.2011.10793.x Published: 01 June 2012
Abstract 4115: GS-19, a novel GSK inhibitor suppresses the growth of pancreatic cancer cells by inhibiting EGFR/AKT/STAT-3 signaling
Authors: Alok Ranjan, Ashlee Birkenfeld, Jianyu Lu, Duy Hua, Sanjay K. Srivastava
Journal: Cancer Research (2014)

Abstract Pancreatic cancer remains the fourth leading cause of cancer related deaths in the United States. Therefore, identification of novel strategies to control and treat pancreatic cancer is of great importance. GS-19 is a novel compound recently found to be a GSK inhibitor. In this study, we determined the anti-cancer effects of GS-19 in pancreatic cancer cells. GS-19 treatment inhibited the growth of Panc-1 and BxPC-3 cells in a concentration-dependent manner. Both the cell lines treated with GS-19 exhibited G-1 cell cycle arrest as well as apoptosis. Western blot analysis of both BxPC-3 and Panc-1 cells treated with GS-19 inhibited the activation (phosphorylation) and expression of key survival signaling proteins such as EGFR, STAT3 and AKT. The apoptosis induced by GS-19 was associated with cleavage of caspase-3 and PARP. Taken together, our results suggest that GS-19 suppress pancreatic cancer cell growth by inhibiting EGFR/AKT/STAT-3 signaling. However, further mechanistic studies are in progress to establish the role of EGFR/AKT/STAT-3 signaling in pancreatic cancer cells. [The studies in part were supported by R01 grant CA129038 awarded by NIH to S.K.S.] Citation Format: Alok Ranjan, Ashlee Birkenfeld, Jianyu Lu, Duy Hua, Sanjay K. Srivastava. GS-19, a novel GSK inhibitor suppresses the growth of pancreatic cancer cells by inhibiting EGFR/AKT/STAT-3 signaling. [abstract]. In: Proceedings of the 105th Annual Meeting of the American Association for Cancer Research; 2014 Apr 5-9; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2014;74(19 Suppl):Abstract nr 4115. doi:10.1158/1538-7445.AM2014-4115
Association of a Mutation in <i>LACC1</i> With a Monogenic Form of Systemic Juvenile Idiopathic Arthritis
Authors: Salma M. Wakil, Dorota M. Monies, Mohamed Abouelhoda, Nada Al‐Tassan, Haya Al‐Dusery, Ewa A. Naim, Banan Al‐Younes, Jameela Shinwari, Futwan A. Al‐Mohanna, Brian F. Meyer, Sulaiman Al‐Mayouf
Journal: Arthritis & Rheumatology (2014)

Objective The pathologic basis of systemic juvenile idiopathic arthritis (JIA) is a subject of some controversy, with evidence for both autoimmune and autoinflammatory etiologies. Several monogenic autoinflammatory disorders have been described, but thus far, systemic JIA has only been attributed to a mutation of MEFV in rare cases and has been weakly associated with the HLA class II locus. This study was undertaken to identify the cause of an autosomal‐recessive form of systemic JIA. Methods We studied 13 patients with systemic JIA from 5 consanguineous families, all from the southern region of Saudi Arabia. We used linkage analysis, homozygosity mapping, and whole‐exome sequencing to identify the disease‐associated gene and mutation. Results Linkage analysis localized systemic JIA to a region on chromosome 13 with a maximum logarithm of odds score of 11.33, representing the strongest linkage identified to date for this disorder. Homozygosity mapping reduced the critical interval to a 1.02‐Mb region defined proximally by rs9533338 and distally by rs9595049. Whole‐exome sequencing identified a homoallelic missense mutation in LACC1 , which encodes the enzyme laccase (multicopper oxidoreductase) domain–containing 1. The mutation was confirmed by Sanger sequencing and segregated with disease in all 5 families based on an autosomal‐recessive pattern of inheritance and complete penetrance. Conclusion Our findings provide strong genetic evidence of an association of a mutation in LACC1 with systemic JIA in the families studied. Association of LACC1 with Crohn's disease and leprosy has been reported and justifies investigation of its role in autoinflammatory disorders.
Variants of phosphohexose isomerase in gastrointestinal and mammary carcinoma: isoelectric focusing patterns of normal and tumor tissues derived from surgical specimens of the same patient.
Authors: Matthias Baumann, Damian Jezussek, Ralf-Torsten Richter, Karl Brand
Journal: Cancer Research (1988)

Abstract  The occurrence of charge variants of phosphohexose isomerase was elucidated in cancerous and, for comparison, in noncancerous tissues obtained from the same organ. Surgical specimens from 35 patients with gastrointestinal and mammary carcinoma were studied by means of the isoelectric focusing (IEF) technique. Differences in the IEF pattern could be demonstrated in 90% of the patients with gastric cancer. Corresponding values for the patients with colorectal and mammary carcinoma were 50 and 73%, respectively. Almost all normal specimens proved to be monomorphic, revealing only the major basic band with a pI of 9.1. In most of the tumors, additional bands of pI 8.9 and 8.6 were found. This “typical” IEF pattern in tumor tissues was observed in 60% of gastric and 73% of mammary tumors, but in only 36% of colorectal tumors. The results obtained suggest that the IEF pattern of phosphohexose isomerase in tumor tissue might be a useful tool for tumor diagnosis.
Abstract 968: β-catenin plays an important role in lung tumor development induced by EGFR mutations
Authors: Sohei Nakayama, Natasha J. Sng, Julian Carretero, Robert Welner, Yuichiro Hayashi, Mihoko Yamamoto, Tan J. Alistair, Norihiro Yamaguchi, Hiroyuki Yasuda, Li Danan, Kenzo Soejima, Soo A. Ross, Costa B. Daniel, Kwok-Kin Wong, Susumu S. Kobayashi
Journal: Cancer Research (2014)

Abstract The discovery of somatic mutations in epidermal growth factor receptor (EGFR) and the development of EGFR tyrosine kinase inhibitors (TKIs), such as gefitinib and erlotinib, have revolutionized treatment for non-small cell lung cancer (NSCLC). Resistance to TKIs emerges in almost all patients, but currently no effective treatment is available.Therefore, novel strategies to either prevent or overcome resistance are sorely needed. Here we show that β-catenin is essential for development of EGFR mutated lung cancers. We found that β-catenin was upregulated, translocated to the nucleus, and subsequently activated in both EGFR mutated lung cancer cell lines and EGFR mutation driven lung tumors. We demonstrated that mutant EGFR preferentially bound to β-catenin and caused tyrosine-phosphorylation of β-catenin. Tyrosine-phosphorylation of β-catenin led to stabilization, nuclear translocation, and transcriptional activity particularly in cells harboring EGFR-L858R (LR)-T790M (TM). Pharmacological β-catenin inhibition using ICG-001, which specifically blocks the CBP-β-catenin interaction, suppressed growth of both H1975 cells harboring EGFR-LR-TM and lung tumors in EGFR-LR-TM transgenic mice. To further examine whether β-catenin plays an important role in lung tumorigenesis, we generated an EGFR-LR-TM lung cancer mouse model in which the β-catenin gene (Ctnnb1) can be conditionally deleted. Genetic deletion of Ctnnb1 dramatically reduced lung tumor formation and showed significantly longer survival. Taken together, our data suggest that β-catenin plays an important role in mutant EGFR-driven lung tumorigenesis and that targeting the β-catenin pathway may provide novel strategies to prevent lung cancer development and/or overcome resistance to EGFR TKIs. Citation Format: Sohei Nakayama, Natasha J. Sng, Julian Carretero, Robert Welner, Yuichiro Hayashi, Mihoko Yamamoto, Tan J. Alistair, Norihiro Yamaguchi, Hiroyuki Yasuda, Li Danan, Kenzo Soejima, Soo A. Ross, Costa B. Daniel, Kwok-Kin Wong, Susumu S. Kobayashi. β-catenin plays an important role in lung tumor development induced by EGFR mutations. [abstract]. In: Proceedings of the 105th Annual Meeting of the American Association for Cancer Research; 2014 Apr 5-9; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2014;74(19 Suppl):Abstract nr 968. doi:10.1158/1538-7445.AM2014-968
THE ANGLE OF CLEARANCE OF THE LEFT VENTRICLE
Authors: A RAVIN, C M NICE
Journal: Annals of Internal Medicine (1952)

Article1 June 1952THE ANGLE OF CLEARANCE OF THE LEFT VENTRICLEABE RAVIN, F.A.C.P., CHARLES M. NICE, F.A.C.P.ABE RAVIN, F.A.C.P.Search for more papers by this author, CHARLES M. NICE, F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-36-6-1413 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptWhen during fluoroscopy a patient is slowly rotated into the left anterior oblique position, the left ventricle, which at first overlies the shadow of the vertebrae, gradually separates from the vertebral column. The angle through which an upright subject must be rotated in the left anterior oblique position in order to separate the left lower cardiac border (left ventricle) from the vertebral column is the angle of clearance of the left ventricle. Wilson1first used this term and determined this angle by means of a rotating turntable. In 119 normal children ranging in age from five to 15 years, she...Bibliography1. Wilson MG: Clinical radioscopic studies of the heart in children, Am. J. Dis. Child. 47: 750, 1934. CrossrefGoogle Scholar2. KuttnerReyersbach AGG: The value of special radiologic procedures in detecting cardiac enlargement in children with rheumatic heart disease, Am. Heart J. 18: 213, 1939. CrossrefGoogle Scholar3. JacksonEinsteinBlauKelly RLRAAHG: Angle of clearance of the left ventricle as an index to cardiac size, Am. J. Dis. Child. 68: 157, 1944. CrossrefGoogle Scholar4. McIntoshJackson CBRL: Angles of clearance, Am. J. Dis. Child. 71: 357, 1946. CrossrefMedlineGoogle Scholar5. Roesler H: Clinical Roentgenology of the Cardiovascular System, 1943, Charles C. Thomas, Springfield, Illinois. CrossrefGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: *Received for publication December 12, 1951.From the Cardio-Pulmonary Laboratory of the National Jewish Hospital and the Department of Medicine of the University of Colorado School of Medicine.A portion of the data in this article was presented by Charles M. Nice in a thesis for Master of Sciences in The Clinical Graduate School of the University of Colorado School of Medicine. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 June 1952Volume 36, Issue 6Page: 1413-1422KeywordsCardiac ventriclesChildrenGraduate medical educationHospital medicineLeft ventricleResearch laboratoriesSpineVertebrae ePublished: 1 December 2008 Issue Published: 1 June 1952 PDF downloadLoading ...
Psychosomatic Medicine
Authors: M. Rotmann
Journal: Psychotherapy and Psychosomatics (1973)

The clinical section of the Department of Internal Medicine at the University of Ulm consists of a 300-bed hospital. The 17 wards are divided into 12- to 20-bed units. There are no specialty wards but routine specialty rounds each week on all wards. An intensive psychosomatic consultation service was instituted in 1970. It covered 5 wards and the intensive care unit. The consultants were advanced residents in internal medicine and also candidates in psychoanalytic training. The consultation technique was threefold: (1) consultee-oriented, (2) patient-oriented and (3) operational group-oriented. This setting will be described in some detail.
Human cloning is justified in preventing genetic disease
Authors: Debashis Singh
Journal: BMJ (2004)

Cloning babies would be desirable under certain circumstances, says Ian Wilmut, leader of the team that created Dolly the sheep, the world's first cloned animal.

He made his comments in an article published last week in New Scientist (2004;181(2435):12), saying that it would be acceptable if it helped prevent genetic disease. “[Human] cloning promises such great benefits that it would be immoral not to do it,” wrote Dr Wilmut, joint head of the department of gene expression and development at the Roslin Institute, Edinburgh.

Dr Wilmut's comments come after a team …
Natural killer cells and B lymphocytes in peripheral blood of patients with psoriasis
Authors: T. Gambichler, Y. Zhang, S. Höxtermann, A. Kreuter
Journal: British Journal of Dermatology (2012)

Funding sources: none. Conflicts of interest: none declared. Madam, We read with great interest the paper of Luci et al.,1 who recently observed that peripheral natural killer (NK) cells exhibit qualitative and quantitative changes in patients with psoriasis. Their findings prompted us to assess circulating NK cells, as well as other lymphocyte subsets, in a large German cohort of patients with psoriasis, and in healthy controls. We assessed patients with chronic plaque psoriasis who had attended our clinic with active disease requiring therapy. Patients receiving systemic therapy at presentation, including phototherapy, immunosuppressive/modulating drugs and biologics, were not included in the analysis. Furthermore, a healthy age‐ and sex‐matched study population served as controls. This study was conducted in light of the Declaration of Helsinki and followed a protocol approved by our institutional review board (second amendment, no. 3096‐07). Blood collection was performed prior to initiation of treatment. In order to identify and determine the absolute counts and percentages of NK cells and lymphocytes in the peripheral blood, flow cytometric methods were performed using antibodies for T lymphocytes (CD3+), B lymphocytes (CD19+), helper/inducer T lymphocytes (CD3+CD4+), suppressor/cytotoxic T lymphocytes (CD3+CD8+) and NK cells (CD3−CD16+CD56+). The FACSCanto II™ cytometer (BD Biosciences, San Jose, CA, U.S.A.), equipped with 633 nm red and 488 nm blue lasers, together with computer hardware and FACSDiva‐software™ were used. Data analysis was performed using the statistical package MedCalc Software (Mariakerke, Belgium). Distribution of data was assessed by the D’Agostino–Pearson test. Normally distributed data are expressed as mean ± SD, and non‐normally distributed data are expressed as median and range. Data were analysed using the independent t‐test, Mann–Whitney U‐test and regression analysis. Bonferroni corrections for multiple comparisons were also performed. P‐values < 0·05 were considered significant.
Prevent Genetically Modified Organisms From Escaping Into Nature, Report Urges
Authors: Tracy Hampton
Journal: JAMA (2004)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Still Life With Peonies
Authors: M Therese Southgate
Journal: JAMA (2006)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
<i>IDH</i> mutations are closely associated with mutations of <i>DNMT3A</i>, <i>ASXL1</i> and <i>SRSF2</i> in patients with myelodysplastic syndromes and are stable during disease evolution
Authors: Chien‐Chin Lin, Hsin‐An Hou, Wen‐Chien Chou, Yuan‐Yeh Kuo, Chieh‐Yu Liu, Chien‐Yuan Chen, Yan‐Jun Lai, Mei‐Hsuan Tseng, Chi‐Fei Huang, Ying‐Chieh Chiang, Fen‐Yu Lee, Ming‐Chih Liu, Chia‐Wen Liu, Jih‐Luh Tang, Ming Yao, Shang‐Yi Huang, Bor‐Sheng Ko, Shang‐Ju Wu, Woei Tsay, Yao‐Chang Chen, Hwei‐Fang Tien
Journal: American Journal of Hematology (2013)

Current information about clinical significance of IDH mutations in myelodysplastic syndromes (MDS), their association with other genetic alterations and the stability during disease progression is limited. In this study, IDH mutations were identified in 4.6% of 477 patients with MDS based on the FAB classification and in 2.2 % of 368 patients based on the 2008 WHO classification. IDH mutations were closely associated with older age, higher platelet counts, and mutations of DNMT3A (36.4% vs. 8.7%, P &lt; 0.001), ASXL1 (47.6% vs. 22.0%, P = 0.007), and SRSF2 (45.5% vs. 11.8%, P &lt; 0.001). IDH2 mutation was a poor prognostic factor for overall survival in patients with lower‐risk MDS, based on international prognosis scoring system (IPSS), FAB classification, WHO classification, or revised IPSS (all P ≦ 0.001), but not in higher‐risk groups. Sequential studies in 151 patients demonstrated that all IDH ‐mutated patients retained the same mutation during disease evolution while none of the IDH ‐wild patients acquired a novel mutation during follow‐ups. In conclusion, IDH mutation is a useful biomarker for risk stratification of patients with lower‐risk MDS. IDH mutations are stable during the clinical course. The mutation, in association with other genetic alterations, may play a role in the development, but not progression of MDS.Am. J. Hematol. 89:137–144, 2014. © 2013 Wiley Periodicals, Inc.
Abstract 285: The rSO2 Value Is Useful as a New Index of ROSC
Authors: Yoshihito Ogawa, Tadahiko Shiozaki, Tomoya Hirose, Mitsuo Ohnishi, Hiroshi Ogura, Takeshi Shimazu, Masashi Kishi
Journal: Circulation (2014)

Background:  It is important to continue chest compression on cardio-pulmonary resuscitation (CPR) without interruption. However, we can not but stop chest compression during checking pulse. We reported that Regional cerebral Oxygen Saturation (rSO2) value was not elevated by manual chest compression and that mechanical chest compression increased a little rSO2 value on CPR without return of spontaneous circulation (ROSC). Our hypothesis is that rSO2 value becomes a good parameter of ROSC.   Purpose:  The purpose of this study is to examine the utility of rSO2 value as index of ROSC.   Method:  Retrospectively, we considered the rSO2 value of the out-of -hospital cardiac arrest patients from December 2012 to December 2013. During CPR, rSO2 were recorded continuously from the forehead of the patients by TOS-OR (Japan). CPR for patients with OHCA was performed according to the JRC-guidelines 2010.   Result:  Forty-four patients with OHCA were included in this study. The rSO2 value of arriving hospital, manual chest compression, mechanical chest compression and ROSC were 39.2±5.0%, 38.3±4.5%, 45.0±7.1%, 58.7±5.9%. In ROSC, with rSO2 cutoff value of 55%, the specificity and sensitivity were 77% and 97%, respectively. The areas under the receiver operating characteristic curve (ROC-AUC) of rSO2 was 0.972, respectively.   Conclusion:  The rSO2 value during CPR would become the new index of ROSC.