THE INHERITANCE OF SPONDYLITIS RHIZOMELIQUE (ANKYLOSING SPONDYLITIS) IN THE K. FAMILY
Authors: H H RIECKER, J V NEEL, A TEST
Journal: Annals of Internal Medicine (1950)

Article1 November 1950THE INHERITANCE OF SPONDYLITIS RHIZOMELIQUE (ANKYLOSING SPONDYLITIS) IN THE K. FAMILYHERMAN H. RIECKER, M.D., F.A.C.P., JAMES V. NEEL, Ph.D., M.D., AVERY TEST, Ph.D.HERMAN H. RIECKER, M.D., F.A.C.P.Search for more papers by this author, JAMES V. NEEL, Ph.D., M.D.Search for more papers by this author, AVERY TEST, Ph.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-33-5-1254 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptSpondylitis rhizomelique, an ankylosing arthritis of the spine generally associated with the names of von Bechterew, Marie, and Strümpell, is a disease of obscure etiology. In the early work on this condition, Magnus-Levy1drew attention to the association of spondylitis rhizomelique and rheumatoid arthritis of the extremities, and the disease is now generally regarded as a form of rheumatoid arthritis, although there are dissenting opinions.2, 3Many factors have been implicated as causative agents. The present report records in some detail a kindred in which at least five members have ankylosing spondylitis, and considers the part that an hereditary influence...Bibliography1. Magnus-Levy A: Ueber die chronische Steifigkeit der Wirbelsäule, Mitt. Grenzgeb. Med. u. Chir. 9: 626-658, 1902. Google Scholar2. Osgood RB: The medical and social approaches to the problem of chronic rheumatism, Am. J. M. Sc. 200: 429-445, 1940. CrossrefGoogle Scholar3. Ravenna P: A review of recent Italian work on rheumatism. II. Chronic rheumatism, Ann. Rheumat. Dis. 2: 1-18, 1940. CrossrefMedlineGoogle Scholar4. Hermann R: Über die Erblichkeit bei den Arthrosis degenerativa, Ztschr. Menschl. Vererbungs.-u. Konstitutionl. 19: 707-720, 1936. Google Scholar5. StecherHersh RMAH: Heberden's nodes: the mechanism of inheritance of hypertrophic arthritis of the fingers, J. Clin. Investigation 23: 699-704, 1944. CrossrefMedlineGoogle Scholar6. Talbott JH: Serum urate in relatives of gouty patients, J. Clin. Investigation 19: 645-648, 1940. CrossrefMedlineGoogle Scholar7. SmythFreyberg CJRH: A study of the hereditary nature of gout; a report of two families, Ann. Int. Med. 16: 46-56, 1942. LinkGoogle Scholar8. Neel JV: The clinical detection of the genetic carriers of inherited disease, Medicine 26: 115-153, 1947. CrossrefMedlineGoogle Scholar9. WilsonSchweitzerLubschez MGMDR: The familial epidemiology of rheumatic fever: genetic and epidemiologic studies. I. Genetic studies, J. Pediat. 22: 468-492, 1943. CrossrefGoogle Scholar10. HolstiRantasalo #V: On the occurrence of arthritis in Finland, Acta med. Scandinav. 88: 180-195, 1936. CrossrefGoogle Scholar11. HolstiHuuskonen #AJ: Heredo-familial arthritis, Acta med. Scandinav. Suppl. 89: 128-138, 1938. Google Scholar12. Hangarter W: Erbliche Disposition bei chronischer Arthritis, Ztschr. Ges. Anat. Abt. II, Ztschr. f. Konstitutionsl. 16: 244-260, 1932. Google Scholar13. DawsonTyson MHTL: The relationship between rheumatic fever and rheumatoid arthritis, Proc. Am. Ass. for Study and Control of Rheum. Dis. 2: 132-142, 1935. Google Scholar14. Coss JA: Juvenile rheumatoid arthritis, M. Clin. North America 30: 568-575, 1946. CrossrefGoogle Scholar15. Von Bechterew W: Steifigkeit der Wirbelsäule und ihre Verkrümmung als besondere Erkrankungsforme, Neurol. Centralbl. 12: 426-434, 1893. Google Scholar16. MarieAstié PC: Sur un cas de cyphose hérédo-traumatique, Presse méd. 2: 205-206, 1897. Google Scholar17. Geilinger W: Beitrag zur Lehre von der ankylosierenden Spondylitis mit besonderer Berücksichtigung ihrer Beziehungen zur Spondylitis deformans, Z. Orthop. Chirurgie 38: 183-269, 1918. Google Scholar18. WeilAllolio AJB: Spondylitis ankylopoietica (Bechterew) bei Brudern, Deutsche med. Wchnschr. 56: 2038-2039, 1930. CrossrefGoogle Scholar19. Ehrlich C: Die sogenannte Bechterew'sche Krankheit. Eine chronische zur Versteifung führende Erkrankung der Wirbelsäule, Berlin, R. Hobbing, 1930, pp. 58. Google Scholar20. Blair HC: Spondylitis adolescens—Struempell-Marie disease; practical and theoretical considerations, Surg., Gynec. and Obst. 74: 663-670, 1942. Google Scholar21. Dekkers HJ: Spondylarthritis ankylopoietica (spondylosis rhizomelica) combined with peripheral arthritis, Acta med. Scandinav. 113: 506-526, 1943. CrossrefGoogle Scholar22. StecherHauser RMH: Ankylosing spondylitis. Report of occurrence in two brothers, Am. J. Roentgenol. 56: 601-606, 1946. Google Scholar23. Fischer A: Rheumatismus und Grenzgebiete, Fachbücher f. Ärtze, Berlin, Julius Springer, 1933, xv, pp. vi and 223. CrossrefGoogle Scholar24. HerrickTyson WWTL: Medical aspect of ankylosing spondylitis (Marie-Strümpell), Ann. Int. Med. 15: 994-1001, 1941. LinkGoogle Scholar25. ClaussenKober FE: Über die Veranlagung zu Bechterewscher Krankheit und ihr Wesen, Ztschr. f. menschl. Vererb.- u. Konstitutionsl. 22: 268-303, 1939. Google Scholar26. Comroe BI: Arthritis and allied conditions, 1944, Lea and Febiger, Philadelphia, p. 1359. Google Scholar27. StephensKerby FEJP: Hereditary Legg-Calve-Perthe's disease, J. Hered. 37: 153-160, 1946. CrossrefMedlineGoogle Scholar28. Gill AB: Relationship of Legg-Perthe's disease to the function of the thyroid gland, J. Bone and Joint Surg. 25: 892-901, 1943. Google Scholar29. LevyGirard LJPM: Legg-Perthe's disease, J. Bone and Joint Surg. 24: 663-671, 1942. Google Scholar30. Bauer J: Constitution and disease, 1945, Grune and Stratton, New York, pp. xiii and 247. Google Scholar31. DraperAllenSpock GGJC: Studies in human constitution. VI. Clinical genetics, J. A. M. A. 92: 2149-2153, 1929. CrossrefGoogle Scholar32. Proebster R: Bemerkungen zum chronischen Gelenkrheumatismus an Hand einiger Fälle von rheumatischer Erkrankung der kleinen Wirbelgelenke, Arch. f. orthop. u. Unfall-Chir. 21: 346-385, 1923. CrossrefGoogle Scholar33. Miller JL: Differential diagnosis between Strümpell-Marie disease and osteoarthritis of the spine, J. Lab. and Clin. Med. 22: 19-25, 1936. Google Scholar34. Kinsella RA: Differential diagnosis of acute rheumatic fever, J. Lab. and Clin. Med. 22: 26-29, 1936. Google Scholar35. Pottenger RT: Constitutional factors in arthritis with special reference to incidence and role of allergic diseases, Ann. Int. Med. 12: 323-333 (Sept.) 1938. LinkGoogle Scholar36. Reed SC: Harelip in the house mouse. I. Effects of the external and internal environments, Genetics 21: 339-360, 1936. CrossrefMedlineGoogle Scholar37. Pearson ES: Congenital eye anomalies in albino mice, Nature, London 114: 433, 1924. CrossrefGoogle Scholar38. Loeffler L: Über eine mutation bei der weissen Hausmans, ihre Genetik und deren Bedeutung für die menschliche Erblehre, Z. i. Abst. Vererb. 61: 409-446, 1932. Google Scholar39. Danforth CH: Hereditary doubling suggesting anomalous chromatin distribution in the mouse, Proc. Soc. Exper. Biol. and Med. 23: 145-147, 1925. CrossrefGoogle Scholar40. PolleySlocumb HFCH: Rheumatoid spondylitis; a study of 1,035 cases, Ann. Int. Med. 26: 240-249, 1947. LinkGoogle Scholar41. Kemen A: Röntgenbehandlung der rheumatischen Erkrankungen ins besondere der Bechterewschen Erkrankung, Verhandl. d. deutsch. Gesellsch. f. inn. Med. 49: (Deutsche Gesellsch. f. Rheumabe Kämpf.) 46-54, 1937. Google Scholar42. Scott SG: Wide field x-ray treatment, 1939, George Newnes, Ltd., London, pp. xiv and 80. Google Scholar43. Hare HF: The diagnosis of Marie-Strümpell arthritis with certain aspects of treatment, New England J. Med. 223: 702-705, 1940. CrossrefGoogle Scholar44. SmythFreybergLampe CJRHI: Roentgen therapy for rheumatoid arthritis of the spine, J. A. M. A. 117: 826-831, 1941. CrossrefGoogle Scholar45. SmithBolandHench RTEWPS: The effect of roentgen therapy in rheumatoid spondylitis, Read before American Rheumatism Assn., New York City, May 25, 1946. Google Scholar46. Freyberg RH: Roentgen therapy for rheumatic disease, M. Clin. North America 30: 603-615, 1946. CrossrefGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Ann Arbor, Michigan*Received for publication September 30, 1948.From the Staff of St. Joseph's Mercy Hospital, Ann Arbor, Michigan; the Department of Human Heredity, Laboratory of Vertebrate Biology, University of Michigan, Ann Arbor, Michigan.Grateful acknowledgment is tendered the Board of Governors of the Horace H. Rackham School of Graduate Studies of the University of Michigan for their support of this study.The references quoted here are only some of the more recent, key references to an extensive literature. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byRole of Human Leukocyte Antigens (HLA) in Autoimmune DiseasesRole of Human Leukocyte Antigens (HLA) in Autoimmune DiseasesSpondylitis ankylosansAnkylosing Spondylitis in a Large Kindred: Clinical and Genetic StudiesSpondylitis Ankylopoetica. 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SMYTH, M.D., F.A.C.P. 1 November 1950Volume 33, Issue 5Page: 1254-1273KeywordsAnkylosing spondylitisArthritisEtiologyGraduate medical educationHeredityResearch laboratoriesRheumatoid arthritisSpineSpondylitis ePublished: 1 December 2008 Issue Published: 1 November 1950 PDF downloadLoading ...