tbuckley/cabot-search huggingface dataset:
Abstract 3595: Chloride Intracellular Channel-4 Determines Native Collateral Density
Authors: Dan Chalothorn, Hua Zhang, Jennifer E Smith, Nicarter Gordon, John C Edwards, James E Faber
Journal: Circulation (2008)

The density of native (pre-existing) collaterals in healthy tissue and their capacity to enlarge in occlusive disease (arteriogenesis) are major determinants of tissue injury in ischemia. Mechanisms regulating arteriogenesis remain unclear. Moreover, nothing is known about what specifies formation of native collaterals, except our report that VEGF contributes to native collateral formation (Clayton et al FASEB J 21:LB352, 2007). Recently, chloride intracellular channel proteins (CLICs) have been implicated in cellular processes including cell hollowing. CLIC1 and CLIC4 are expressed by endothelial cells, and VEGF-induced cell hollowing is critical for vascular formation in the embryo and angiogenesis in ischemia. Therefore, we examined CLIC1−/− and CLIC4−/− (null) mice for effects on native collateral density in healthy tissues and on arteriogenesis and angiogenesis in a hindlimb model of ischemia. Responses of CLIC1−/−mice did not differ from wild-type in any experiment. In contrast, CLIC4−/− showed a greater reduction in perfusion immediately after femoral ligation (p&lt;0.05 here and all statements below). Since baseline capillary density and collateral diameter were not different from wild-type, this suggested CLIC4−/− have reduced native collateral density. This was confirmed angiographically. In agreement, during 10 days after ligation CLIC4−/− mice had worse recovery of perfusion, greater ischemia and atrophy, and more impaired limb use, whereas collateral remodeling was unaffected. While ischemia increased expression of CLIC1 and CLIC4 similarly in wild-type mice, CLIC1 was augmented 3-fold in CLIC4−/−, suggesting CLIC1 may compensate for absence of CLIC4. Despite greater ischemia in CLIC4−/− mice, HIF1α and VEGF increased less in CLIC4−/−, suggesting CLIC4 may reside upstream of Hif1α-VEGF signaling. Native collateral density in the cerebral circulation of CLIC4−/− mice (but not CLIC1−/−) was also greatly reduced, resulting in 4-fold larger infarctions. This reduced collateral density in adults was associated with reduced formation and stabilization of nascent collaterals in the newborn. Hence, CLIC4 represents the second gene identified, besides VEGF, that specifies formation of the native collateral circulation.
Abstract 16624: Nucleoside Tri(di)phosphohydolase 1 Protects Against Thrombosis in a Mouse Model of Deep Vein Thrombosis
Authors: Nataliya N Dolgacheva, Jessica J Ray, Matthew C Hyman, Yogendra Kanthi, Dallas Slack, Jose A Diaz, Daniel D Myers, Thomas Wakefield, David J Pinsky
Journal: Circulation (2011)

Background: Deep venous thrombosis (DVT) mainly affects the large veins of legs and pelvis. Blood clots often embolize to the lung resulting in significant mortality risk. Nucleoside tri(di)phospho...
Coronary Artery Disease Severity Selectively Correlates with Atheroma Burden of the Proximal Carotid Bulb and the Distal Thoracic Aorta
Authors: Ilias Kylintireas, Cheerag Shirodaria, Justin Lee, Colin Cunnington, Charalambos Antoniades, Matthew Robson, Jane Francis, Stefan Neubauer, Keith Channon, Robin Choudhury
Journal: Circulation (2008)
Abstract 4000: Prognostic Significance Of Low Response To Clopidogrel Assessed By A Point-of-care Assay On Thrombotic Events Within 6 Month Follow-up After Drug-eluting Stent Implantation In Patients With Acute Coronary Syndrome
Authors: Kyounghoon Lee, Seung-Hwan Lee, Young-Jin Youn, Seong-Yoon Kim, Jang-Young Kim, Byung-Su Yoo, Junghan Yoon, Kyung-Hoon Choe
Journal: Circulation (2008)

Background: Recent evidences suggested that low response or resistance to clopidogrel is associated with recurrent atherothrombotic events after drug eluting stent (DES) implantations. Acute coronary syndrome is a well-known predictor of stent thrombosis (ST) or cardiac death. We prospectively evaluated the association between low response to clopidogrel assessed by VerifyNow P2Y12 assay (Accumetrics Inc, CA) and ST or cardiac death after DES implantation in patients with acute coronary syndrome. Methods: We enrolled consecutive 237 patients (160 males, 65.2±10.3 years) with acute coronary syndrome and DES implantations. Low response to clopidogrel was defined as the less than 20% inhibition of P2Y12 receptor assessed by VerifyNow P2Y12 assay. The composite endpoint was defined to cardiac death or ST by definitions of the Academic Research Consortium within 6 months after the index procedure. Results: Baseline demographic characteristics were similar between normal response (142 cases) and low response (9...
The Measurement of Proliferation in Tissue Cultures by Enumeration of Cell Nuclei
Authors: Katherine K. Sanford, Wilton R. Earle, Virginia J. Evans, Helen K. Waltz, John E. Shannon
Journal: JNCI Journal of the National Cancer Institute (1951)

Journal Article The Measurement of Proliferation in Tissue Cultures by Enumeration of Cell Nuclei Get access Katherine K. Sanford, Katherine K. Sanford Search for other works by this author on: Oxford Academic PubMed Google Scholar Wilton R. Earle, Wilton R. Earle Search for other works by this author on: Oxford Academic PubMed Google Scholar Virginia J. Evans, Virginia J. Evans Search for other works by this author on: Oxford Academic PubMed Google Scholar Helen K. Waltz, Helen K. Waltz Search for other works by this author on: Oxford Academic PubMed Google Scholar John E. Shannon John E. Shannon National Cancer Institute, National Institutes of Health, U. S. Public Health Service, Bethesda, Md. Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 11, Issue 4, February 1951, Pages 773–795, https://doi.org/10.1093/jnci/11.4.773 Published: 01 February 1951 Article history Received: 27 September 1950 Published: 01 February 1951
Evidence of person-to-person transmission within a family cluster of novel coronavirus infections, United Kingdom, February 2013.
Authors: Mamoona Tahir, Roger Gajraj, Madhu Bardhan, Huda Mohammed, Louise Dyke, Petra Charlemagne, Rea Alves, David Kirrage, Dan Killalea, Kate James, Melinda Kemp, Harsh Duggal, Robert Carr, Musarrat Afza, Nicholas Aigbogun, Bharat Sibal, Ruth Harrell, Obaghe Edeghere, Keith Neal, Sue Ibbotson, Nimal Wickramasinghe, Nick Sherwood, Beryl Oppenheim, Louise Hopton, Husam Osman, Erasmus Smit, Sowsan Atabani, Judith Workman, Steve Wilson, Clair Overton-Lewis, Margaret Logan, Rosemary McCann, Marko Petrovic, Vinay Bothra, William Welfare, Barbara Isalska, Julian Barker, Alan Ashworth, Igor Fedor, Claude Seng, Deepti Kumar, Suzanna Matthews, Brian McCloskey, Jonathan Nguyen-Van-Tam, Paul Cosford, Alison Bermingham, Joanna Ellis, Monica Galiano, Angie Lackenby, Richard Myers, Robin Gopal, Maria Zambon, Richard Pebody, Lucy Thomas, Nicki Boddington, Helen K Green, Hongxin Zhao, Iain Kennedy, Ibrahim Abubakar, Jane Jones, Nick Phin, Mike Catchpole, John M Watson
Journal: Eurosurveillance (2013)

In February 2013, novel coronavirus (nCoV) infection was diagnosed in an adult male in the United Kingdom with severe respiratory illness, who had travelled to Pakistan and Saudi Arabia 10 days before symptom onset. Contact tracing identified two secondary cases among family members without recent travel: one developed severe respiratory illness and died, the other an influenza-like illness. No other severe cases were identified or nCoV detected in respiratory samples among 135 contacts followed for 10 days.
Abstract 15110: The Interleukin (IL)-16 Gene Polymorphisms and Risk of Coronary Artery Disease in Chinese Han Population
Authors: Hao Huang, Li Zhang, Rui Liu, Yu-cheng Chen, Xian Li, Qing Zhang, Zhi Zeng
Journal: Circulation (2011)

Introduction: Recent studies have shown that interleukin (IL)-16 is an immunomodulatory cytokine, which plays an important role in some inflammatory and autoimmune diseases. We aimed to investigate...
Abstract 5029: Carotid Plaque Regression Following 6-Month Statin Therapy Assessed by 3T MRI: Comparison With Ultrasound Intima-Media Thickness
Authors: Mark Bowers, John F LaDisa, Leanne Harmann, Robert Prost, Anil Doppalapudi, Raymond Q Migrino
Journal: Circulation (2009)

Statin’s role in short-term plaque regression is unknown. 3T MRI has superior plaque volume (PV) measurement capacity compared to ultrasound intima-media thickness (IMT). We tested the hypothesis that carotid plaque progression is attenuated by 6 month statin therapy and this can be detected by MRI PV but not IMT. Methods : 15 subjects (68±3 years, 4F) with carotid atherosclerosis had carotid MRI (4 channel coil, resolution 0.3– 0.6×0.3– 0.6×2mm) and IMT assessed at baseline and 6 months post-statin treatment. T1, T2, proton density and time of flight images were obtained±12 mm from flow divider. PV and components were measured with Plaqueview software. Same day mean posterior IMT were measured by standard method. Observers were blinded to subject/scan order. Results : LDL changed from 90±7 to 78±7 mg/dL (p=NS). MRI PV decreased (1166±83 to 1084±102 mm 3 , p=0.007). Mean IMT was unchanged (1.14±0.07 vs. 1.14±0.07 mm, p=NS). Change in necrotic and hemorrhage volume correlated with MRI PV change (R=0.8, 0.7, all p&lt;0.001), but not IMT change. In 8 subjects, plaque spatial distribution (6 quadrants) was analyzed (see figure ). Greatest thickness was seen opposite the flow divider (241–300°, p&lt;0.01), a region not accessed by US IMT. Conclusions : In carotid disease, there was a measurable reduction in plaque burden following short-term statin treatment using 3T MRI that was not seen with US IMT. The heterogenous spatial distribution of plaque supports use of volumetric measurement for serial studies. 3T MRI may be useful to assess treatment efficacy, reduce number of subjects needed and be a better imaging tool to assess effects of novel therapies for carotid atherosclerosis in clinical trials.
Abstract 12138: Angiotensin Blockade Reduces Aortic Dilatation in Patients With Marfan Syndrome: A Meta-Analysis
Authors: Partha Sardar, Amartya Kundu, Omosalewa Adenikinju, Gerald Pekler, Saurav Chatterjee, Parasuram Krishnamoorthy, Wilbert S Aronow
Journal: Circulation (2014)

Introduction: Recently few studies evaluated the effects of ACE/ARB in patients with Marfan syndrome. However, as majority of the studies were small and mainly pilot studies, conclusive evidence of benefit with ACE/ARB in this scenario is still pending. The objective of the present meta-analysis was to evaluate the effect of ACE/ARB on the progression of aortic root dilatation in patients with Marfan syndrome. Hypothesis: Treatment with ACE/ARBs is effective for the prevention of aortic-root enlargement in patients with Marfan syndrome. Methods: We searched PubMed, EMBASE, and Cochrane Central Register of Clinical Trials from the inception to April 30, 2013. The main outcome of the present analysis was the change in aortic root diameter with ACE/ABR therapy compared to control. The random effects model of DerSimonian and Laird was used. Results: Four studies were included in the final analysis; three studies were randomized trial and one was observation study. ACE/ARB significantly reduced enlargement of aortic root diameters compared to control; mean difference of -0.97 (95% confidence interval, -1.42 to -0.52; P&lt;0.0001). Consistent benefit of ACE/ARB was observed in all sub-group and sensitivity analyses; against beta blocker, against placebo, in adult patients, with only ARB, analysis with the results from only RCTs. Conclusions: This is the first meta-analysis indicating a beneficial effect of ACE/ARB treatment on aortic root dilatation in patients with Marfan Syndrome. Current evidence supports the use of ARB, specially losartan for this indication.
Inducible Gata1 Suppression As a Novel Strategy to Expand Physiologic Megakaryocyte Production from Embryonic Stem Cells
Authors: Ji-Yoon Noh, Shilpa Gandre-Babbe, Yuhuan Wang, Vincent Hayes, Yu Yao, Paul Gadue, Spencer Sullivan, Stella T. Chou, Vikram R Paralkar, Kellie R Machlus, Joseph E. Italiano, Michael Kyba, Deborah L. French, Mortimer Poncz, Mitchell J. Weiss
Journal: Blood (2014)
Abstract 3406: Plaque Characterization Using Different X-ray Energy By Dual Source CT And Its Comparison With Histology
Authors: Sei Komatsu, Alexander Kuhlmann, Valentine Campean, Dieter Ropers, Ulrike Ropers, Martin Wechsel, Werner G Daniel, Kerstin U Amann, Stephan Achenbach
Journal: Circulation (2007)

Background In addition to high spatial (0.4 mm) and temporal resolution (83 ms), Dual Source CT (DSCT) allows simultaneous imaging with two different x-ray energies. This may be beneficial for tissue characterization. Objectives. To determine the accuracy of ex vivo atherosclerotic plaque characterization with DSCT and to assess the CT attenuation of various plaque components depending on X-ray energy. Materials and Methods. 18 atherosclerotic vessels of coronary, carotid and iliac arteries obatined from autopsy were analyzed by DSCT. Each lumen of the vessels was filled with contrast media (30X Imeron 350). The collimation was 2X64X0.6 mm, rotation time was 330 msec., temporal resolution was 83 msec. Data sets were obtained using a tube voltage of 80, 100, 120, and 140 kV. The x.-ray attenuation of lipid-rich plaque, fibrous plaque, calcified plaque and contrast-enhanced lumen were determined for all x-ray energies by comparison to histology at 25 sites. In addition, cross-sectional images were reconstructed with 0.75 mm slice thickness and 0.4 mm increment. 26 slices at 10 mm interval were analyzed by comprehensive color-coding according to CT number. Results. There were significant differences among CT attenuations of lipid-rich, fibrous and calcified plaque using 80, 100, 120, and 140 kV (Table , p&lt;0.01), respectively. The averaged ratio of CT attenuation of lipid-rich, fibrous plaque, and calcified plaque to the Contrast-enhanced lumen for 80kV and 140kV were −16%, 11%, 14%, respectively (p&lt;0.05). Lipid-rich plaque was well-differentiated with lumen attenuation in all energies. Conclusions. The relationships between lumen enhancement and each plaque component were different as changing the x-ray energy level. Using of varying x-ray energy, DSCT may able to detect atherosclerotic plaque and characterization of plaque components. The Attenuation on Different Energy
Abstract P132: The Optimal Second Phase Duration for Biphasic Truncated Exponential Waveform Defibrillation
Authors: Yongqin Li, Hao Wang, Jun Hwi Cho, Marc Fuller, James Russell, Joe Bisera, Max Harry Weil, Wanchun Tang
Journal: Circulation (2008)

Introduction For termination of ventricular fibrillation (VF), biphasic waveforms have proven more effective than monophasic waveforms. As yet not well defined is the optimal second (negative) phase duration. We therefore examined the best negative phase and comprising delivered energy and peak current based on the measurement of defibrillation threshold. Methods In 10 domestic pigs weighing between 35– 45 (40±3) kg, VF was electrically induced and untreated for 15 seconds. First (positive) phase was maintained in the range of 4.04±0.01ms. Second phase was randomizely adjusted to 1.02, 1.36, 2.04, 3.06 and 6.12 ms utilizing a Philips MRx defibrillator to allow variable duration of the second phase. The 80% defibrillation threshold (DFT80) served to defined optimal duration of the second phase where delivered energy was varied between 72 and 188 Joules. Results The energy was minimal when the second phase duration ranged between 1.36 to 3.06 ms (Figure 1). The peak current was significantly lower when the ...
Trends in pharmacotherapy of Schizoaffective and bipolar affective disorders: a 5-year naturalistic study
Authors: H H Fenn, D Robinson, V Luby, C Dangel, E Buxton, M Beattie, H Kraemer, J A Yesavage
Journal: American Journal of Psychiatry (1996)

The authors' goal was to determine if the actual treatment of schizoaffective and bipolar affective disorders had changed in light of recent clinical drug trials that have suggested that valproate and carbamazepine may be equivalent in efficacy to lithium.Medication utilization rates for each 6-month period from July 1, 1989, to June 30, 1994, were compiled from the clinical database of the Palo Alto Veterans Affairs Medical Center.The use of valproate and valproate plus lithium was negligible in 1989. by 1994, these medication regimens accounted for 25% of the standard antimanic treatments used for bipolar affective disorder and 38% of the treatments used for schizoaffective disorder. Regimens of carbamazepine and carbamazepine plus lithium dropped from 24% of antimanic treatments in 1989 to 18% in 1994. From 1989 to 1994, there was a decline in the rate of lithium monotherapy for treatment of bipolar affective disorder (from 84% to 43%) and schizoaffective disorder (from 100% to 53%).In the past 5 years, valproate monotherapy has increased as a percentage of total antimanic pharmacotherapies, while lithium monotherapy has declined.
Abstract 3964: Regression in Left Ventricular Mass After Aortic Valve Replacement for Chronic Aortic Regurgitation is Unrelated to Prosthetic Valve Size
Authors: Morgan L Brown, Hartzell V Schaff, Rakesh M Suri, Zhuo Li, Thoralf M Sundt, Joseph A Dearani, Richard C Daly, Maurice E Sarano, Thomas A Orszulak
Journal: Circulation (2009)

Objective: Our objectives were to examine the predictors of left ventricular (LV) mass regression following aortic valve replacement (AVR) for chronic aortic valve regurgitation (AR) and to determi...
P0757 : Expression of inhibitory CD158B and CD158E NK cell receptors is associated with significant liver injury in the course of chronic hepatitis C in children
Authors: A. Mania, M. Kaczmarek, P. Kemnitz, I. Mozer-Lisewska, M. Figlerowicz, J. Sikora, W. Sluzewski, J. Żeromski
Journal: Journal of Hepatology (2015)
Abstract 16286: Enhancement of Sudden Death Risk Stratification by Resting 12-Lead EKG Markers When Combined With LV Ejection Fraction: A Community-Based Study
Authors: Carmen Teodorescu, Kyndaron Reinier, Audrey Uy-Evanado, Harpriya Chugh, Jo Ayala, Ronald Mariani, Karen Gunson, Jonathan Jui, Sumeet S Chugh
Journal: Circulation (2011)

Introduction: Abnormalities of repolarization and depolarization, as well as increased heart rate from the resting 12-lead EKG are associated with independently increased risk of sudden cardiac dea...
Treatment of Fractures and Dislocations, 1950–1960
Authors: Thomas B. Quigley, Henry Banks
Journal: New England Journal of Medicine (1960)

The Tibia and FibulaSuch progress as has occurred in the treatment of fractures of both bones of the leg in the past ten years has confused rather than clarified the issues involved. Few bones are so easy to expose surgically; yet nowhere in the skeleton are the penalties of poor technical surgery so great. In a carefully controlled study of delayed union and nonunion in the Los Angeles area, Urist, Mazet and McLean337 found that in 33 of 89 cases of nonunion, open surgery at the time of fracture was followed by an extended period of healing or by . . .
Abstract 3748: MR-pro Midregional Pro-Atrial Natriuretic Peptide and Risk of Cardiovascular Death in Coronary Artery Disease
Authors: Renate Schnabel, Edith Lubos, Christoph Sinning, Christoph Bickel, Hans J Rupprecht, Kreiskrankenhaus Ruesselsheim, Karl J Lackner, J Papassotiriou, J Struck, Thomas F Munzel, Stefan Blankenberg
Journal: Circulation (2007)
Abstract 14268: MiR-133 Modulates Vascular Smooth Muscle Cell Phenotypic Switch in vitro and in vivo
Authors: Claudio Iaconetti, Daniele Torella, Georgina M Ellison, Antonio Curcio, Angela Bochicchio, Carla Vicinanza, Stefania Donato, Walter Sacco, Iolanda Aquila, Isabella Mendicino, Daniele Catalucci, Gianluigi Condorelli, Ciro Indolfi
Journal: Circulation (2010)

Background: MicroRNA (mi-R)-1 and -133 are involved in various cardiovascular processes such as cardiac differentiation, development, hypertrophy and proliferation. However, the role of miR-1 and m...
重症监护治疗学（十）重症监护病房的收住标准
Authors: 林英翔
Journal: BMJ (2001)

重症监护被认为是“为有康复希望的患者提供比在普通病房或特护区内更为细致的观察和进行有创的治疗”。同时 ,为有潜在或已形成器官衰竭的患者进行治疗。最常见的需要支持治疗的器官是肺脏 ,但也应具备诊断、预防和治疗其他器官衰竭的设施。 入住重症监护病房的患者标准 重症监护适于需要高级呼吸支持或需要两个或两个以上器官系统支持的患者。患有一个或多个器官慢性损伤的患者 ,当其他器官发生急性、可逆性衰竭时也需要支持治疗。早期转入重症监护病房尤其评估是否适合入住重症监护病房时应考虑的因素 诊断 疾病的严重程度 年龄 合并症 生理储备状况 预后 可否获得适当治疗 对治疗时间的反应 近期是否发生过心跳呼吸停止
The limits of psychiatry
Authors: L. Culliford
Journal: BMJ (2002)

Editor—Double's paper is thought provoking.1 He may like to know of initiatives aimed, at least in part, at bringing about a synthesis of psychiatry and antipsychiatry. This is in terms of human spirituality.

For the past two years there has been a spirituality and psychiatry special interest group within the Royal College of Psychiatrists (www.rcpsych.ac.uk/college/SIG/spirit), whose membership now stands at close to 500. Spirituality is the forgotten dimension, not only of mental health care2,3 but also of general health care.4 In the group we seek to clarify the meaning of spirituality, defined by Murray and Zentner as “a quality that goes beyond religious affiliation, that strives for inspiration, reverence, awe, meaning and purpose, even in those who do not believe in God. The spiritual dimension tries to be in harmony with the universe, strives for answers about the infinite, and comes essentially into focus in times of emotional stress, physical (and mental) illness, loss, bereavement and death.”5

Although there are obvious overlaps, we are at pains to distinguish spirituality, which is universal and unifying, from religion(s), which are essentially sociocultural phenomenons and potentially divisive. We are looking closely at the relevance of spirituality in mental health care, supported by an extensive and growing evidence base. We are interested in “new paradigm” research methods.1,3,4 We seek to promote spirituality in terms of skills and attitudes as well as knowledge. We are increasingly aware of the benefits for healthcare practitioners—reduced stress levels, improved work satisfaction, and protective effects against burnout, alcohol and substance misuse, and marital and family breakdown—of acquiring and developing spiritual skills.3

I am pleased that Double has taken this step in opening up the debate.
Abstract 11087: T-type Calcium Channel is a Main Portal for Iron Entry in Thalassemic Heart
Authors: Siriporn Chattipakorn, Sirinart Kumfu, Somdet Srichairattanakool, Jongkolnee Settakorn, Suthat Fucharoen, Nipon Chattipakorn
Journal: Circulation (2010)

Iron-overload cardiomyopathy is responsible for many deaths in thalassemia patients. Although L-type calcium channel (LTCC) was proposed as a portal for iron entry and deposit in the heart, its role in the heart of thalassemia subject has never been investigated. Growing evidence demonstrated that reexpression of T-type calcium channel (TTCC) was found in diseased myocardium of adult hearts. However, its existence and role for iron entry in thalassemic hearts is unknown. We tested the hypothesis that both LTCC and TTCC are the main portals for iron entry in thalassemic hearts. Methods: Hearts from heterozygous β-globin knockout thalassemic (HT) mice and wild-type (WT) mice (n=8/group) were used for cultured ventricular cardiomyocytes. Various iron (Fe2+) concentrations (10–160 mg/ml) and pharmacological interventions with transferin receptor (TfR) blocker and divalent metal transporter inhibitor (ebselen), LTCC blocker (verapamil), TTCC blocker (efonidipine), and iron chelator desferoxamine (DFO) were use...