tbuckley/cabot-search huggingface dataset:
Cardiac Problems in Pregnancy: Diagnosis and Management of Maternal and Fetal Disease.
Authors: Uri Elkayam, Norbert Gleicher
Journal: Annals of Internal Medicine (1983)

An updated and expanded edition of the standard book on diagnosis and management of maternal and fetal disease. This practical clinical guide gives information on typical labors and deliveries of the different cardiac diagnoses discussed, supported by excellent EKGs and charts which simplify the information. In straightforward language this book provides detailed descriptions and explanations of the tests and procedures done prenatally, during labor, and postnatally. Each chapter is laid out with numerous headings for quick reference.
Insure Everyone Now, Urges IOM
Authors: Brian Vastag
Journal: JAMA (2004)

Mitochondriaalsomaycontributetobrain disease and injury if they are unable to get to where they are needed in the cell, such as when the organelles are immobilized by various neurotoxins, said Ian Reynolds,PhD,professorofpharmacology at the University of Pittsburgh. Mitochondria are believed to be generated near the nucleus and are then transported to sites within the cell where energy is required. In some of the longest neurons in the body, noted Reynolds, a mitochondrion conceivably could travel as far as a meter from nucleus to synapse. Mitochondria travel along the highwaysandbywaysof thecytoskeleton(online video available), but roadblocks and detours can subvert this mitochondrial trafficking, said Reynolds. “If a mitochondrion is not delivered to a terminal when needed—or, alternatively, if it gets retrieved from a terminal too soon— this could perhaps contribute to the death of a neuron,” he speculated. In cell culture studies, Reynolds and colleagues have discovered that several substances that can be released in large amounts in a stroke, including glutamate, zinc, and nitric oxide, can inhibit mitochondrial movement. However, Reynolds and coworkers found that the neurons could be protected in vitro with the drug wortmannin, which stops zinc from blocking mitochondrial movement. Although preliminary, these findings suggest that targeting substances that inhibit mitochondrial movement may be another useful strategy to investigate for treating neurological disorders.
Abstract 15634: Epigenetic Modifiers Reduce Inflammation and Modulate Macrophage Phenotype to Attenuate Endotoxemia-Induced Acute Lung Injury
Authors: Bahar Barani, Jayakumar Thangavel, Sheeja Rajasingh, Yu-Ting Xuan, Buddhadeb Dawn, Johnson Rajasingh
Journal: Circulation (2014)

Introduction: Acute lung injury (ALI) during sepsis is characterized by bilateral alveolar infiltrates, lung edema, and respiratory failure. Although chemical epigenetic modifiers can potentially limit lung inflammation, to date no study has examined the efficacy of DNA methyl transferase (DNMT) inhibitor Aza (5-Aza 2-deoxycytidine) and histone deacetylase (HDAC) inhibitor TSA (Trichostatin A) combination therapy (Aza+TSA) on inflammation, apoptosis and survival in sepsis. Hypothesis: Therapy with Aza+TSA will modulate cytokines and macrophages to quench inflammation in ALI. Methods and Results: In an LPS-induced ALI mouse model, a single dose of Aza+TSA prevented lung inflammation and injury with significant reduction in mortality as compared with mice treated with either Aza or TSA alone. A significant attenuation of adverse lung histopathological changes, and inflammation was noted. RT-PCR array data showed that LPS-induced primary macrophages expressed mRNA transcripts of pro-inflammatory chemokines (...
Mechanical hemolysis: A low mean cell volume does not always represent microcytosis
Authors: Barbara J. Bain, Mili Shah, Vanlata Varu, Megan Rowley, Rodney Foale
Journal: American Journal of Hematology (2015)

A 56-year-old woman who had had a prosthetic mitral valve replacement 38 years previously presented to cardiology outpatients with a 12-month history of increasing lethargy and shortness of breath. Her hemoglobin concentration and red cell indices on a Sysmex XE-2100 instrument were: RBC 3.86 × 1012/l, Hb 71 g/l, MCV 63.5 fl, MCH 18.4 pg, and MCHC 290 g/l. Prior to examination of her blood film, tests for iron deficiency and hemoglobin H disease had been requested. However, her blood film, rather than showing microcytosis, showed very numerous schistocytes (top). There were also polychromatic macrocytes and the reticulocyte count was 195 × 109/l (5.1%). No estimate of the red cell distribution width was produced by the automated instrument but inspection of the red cell and platelet size histograms (bottom left, patient at the top and normal subject at the bottom) showed two erythrocyte populations, one microcytic (representing the schistocytes) and one normocytic; the schistocytes were also apparent on the platelet size histogram. The instrument “flags” included “fragments?,” “Dimorphic Population” and “PLT Abn Distribution.” Haptoglobin was undetectable. Urinary hemosiderin was strongly positive (bottom right). A diagnosis of mechanical hemolytic anaemia was made. Transesophageal echocardiography was therefore undertaken and showed a perivalvular leak, necessitating surgery. It is important to remember that a low MCV may represent red cell fragmentation as well as microcytosis. A low MCV is usual, for example, in hereditary pyropoikilocytosis. It is good practice to examine a blood film and automated instrument plots when the MCV is reduced.
Abstract 13567: LCZ696, an Angiotensin Receptor Neprilysin Inhibitor, Provides Superior 24-hour Blood Pressure Reduction than Olmesartan in Japanese Patients with Systolic Hypertension
Authors: Kazuomi Kario, Hiromi Rakugi, Masako Yamaguchi, Naoko Okino, Hiromi Gotou, Jack Zhang
Journal: Circulation (2014)

Introduction:  Ambulatory blood pressure monitoring (ABPM) characterizes 24-h rhythm of BP and is useful in evaluating cardiovascular risk.   Objective:  We conducted a randomized double-blind clinical study in Japanese patients with systolic hypertension (SH) to compare LCZ696, a first-in-class angiotensin receptor neprilysin inhibitor, with olmesartan for the effect on 24-h BP profile.   Methods:  Patients with mild-to-moderate SH (office systolic BP [SBP] ≥150 to    Results:  Of the total 1161 randomized patients, 632 patients had both valid baseline and endpoint ABPM measurements, and were included in these analyses. LCZ696 at both 200 and 400 mg daily dose demonstrated significantly (p   Conclusions:  LCZ696 provided superior BP reduction than olmesartan with significantly greater full 24-hour BP reduction in Japanese patients with SH, including patients with nocturnal hypertension.
The Scientific Spirit
Authors: Marten Ten Hoor
Journal: Annals of Internal Medicine (1928)

Article1 November 1928The Scientific SpiritMARTEN TEN HOORMARTEN TEN HOORSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-2-5-474 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptWhen a layman enters the professional presence of a physician, he does so in humility, and possibly even in fear and trembling. Since even a philosopher or a student of philosophy cannot endure the toothache or any other ache patiently, he must also occasionally enter this imposing presence and he too cannot but experience this feeling of timidity, a timidity not unlike that of the penitent approaching the confessional, since it has for its cause fear of the coming diagnosis and of the subsequent prescription of treatment. When a student of philosophy has the temerity to address a whole "College"... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Tulane University New Orleans, Louisiana*An address given at the banquet of the American College of Physicians, Twelfth Annual Clinical Session, New Orleans, La. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 November 1928Volume 2, Issue 5Page: 474-481KeywordsEmotionsFearPain Issue Published: 1 November 1928 PDF downloadLoading ...
Relation Between Ambulatory Electrocardiographic Monitoring and Myocardial Perfusion Imaging to Detect Coronary Artery Disease and Myocardial Ischemia: An ACIP Ancillary Study
Authors: John J. Mahmarian, Richard M. Steingart, Sandra Forman, Barry L. Sharaf, Mary Ellen Coglianese, D. Douglas Miller, Carl J. Pepine, A. David Goldberg, Marilyn F. Bloom, Sheila Byers, Laurel Dvorak, Craig M. Pratt
Journal: Journal of the American College of Cardiology (1997)
Millennial musings
Authors: R. Porter
Journal: BMJ (2000)

Clinical review p 1117

Education and debate pp 1124-54

This week's BMJ is publishing several papers selected from next week's keynote conference of the Millennium Festival of Medicine. The conference will run from Monday 6 November to Friday 10 November at the QEII Conference Centre in London. Some tickets are still available. Those interested should contact the BMA conference unit on 020 7383 6605 or confunit@bma.org.uk

Historians, A J P Taylor once said, make rotten prophets, and I don't suppose that historians of medicine like myself are any exception. All I can see ahead are banana skins. But it's not clear that doctors are any better when it comes to crystal ball gazing. Little over 130 years ago, for example, the distinguished surgeon Sir John Erichsen, of University College Hospital, proclaimed that “the abdomen, the chest and the brain [will] be for ever shut from the intrusion of the wise and humane surgeon.”

More hopefully, back in 1936, Sir Crisp English informed readers of the BMJ that within 20 years “it will be common practice for you to visit patients by aeroplane.” “Telephones with television will be in regular practical use,” he predicted: “The doctor will see on the television screen the tongues and tonsils of his patients … he will also see his guineas, …
Cellular Expression of α-Fetoprotein Gene and Its Relation to Albumin Gene Expression during Rat Azo-Dye Hepatocarcinogenesis
Authors: Jean-Yves Scoazec, Alain Moreau, Gérard Feldmann, Dominique Bernuau
Journal: Cancer Research (1989)

Abstract  During hepatocarcinogenesis, α-fetoprotein (AFP) synthesis may be dramatically increased while albumin synthesis is frequently decreased. Therefore, a reciprocal modulation between both gene expressions has been hypothesized. In this work, we combined  in situ  hybridization and immunoperoxidase on parallel liver tissue sections in order to analyze at the cellular level, AFP gene expression and its relation to ALB gene expression in both early and neoplastic lesions induced by 3MeDAB in the rat. In early lesions, cell populations were heterogeneous as regards AFP expression. High levels of AFP transcripts were detected both in oval type cells and in a subset of basophilic hepatocytes within preneoplastic lesions. In these two highly AFP-expressing cell populations, significant levels of ALB transcripts were concomitantly detected. In the majority of altered hepatocytes, no AFP expression was detected while the level of ALB expression was decreased. In neoplastic lesions, AFP expression was strikingly heterogenous and independent from the degree of morphological differentiation. No evidence of reciprocal modulation with ALB gene expression could be assessed. In both preneoplastic and neoplastic lesions, a few altered hepatocytes displayed significant levels of AFP transcripts while no corresponding protein could be detected; such a discrepancy was not observed for ALB. This work shows that during 3MeDAB hepatocarcinogenesis, AFP gene activation occurs in heterogenous cell populations and according to different cellular patterns. Our observations lend no support to the hypothesis of a reciprocal modulation between AFP and ALB gene expressions during rat azo-dye hepatocarcinogenesis.
Abstract 4189: Discovery of a novel carcinoma-associated EF hand containing protein by mining the dark matter of the human proteome
Authors: Ana Paula Delgado, Pamela Brandao, Sheilin Hamid, Wim Van de Ven, Ramaswamy Narayanan
Journal: Cancer Research (2014)

Abstract The human genome contains thousands of novel and uncharacterized proteins. These unknown genes are difficult to mine due to lack of adequate information. Hence, they remain largely untapped. Reasoning that new druggable targets for cancer can be discovered from these uncharacterized proteins, we have developed a protocol to mine these proteins for cancer relevance. Using various cancer-related databases, we have developed a database of uncharacterized ORF proteins. Numerous ORFs from this database offer druggable targets. To develop a proof of concept for mining these targets, we have chosen one target, C1ORF87 for detailed characterization. The C1ORF87 was analyzed using bioinformatics approaches for mRNA and protein expression, SNPs, LOH, protein motifs and domains and for gene network interactions. We have identified the C1ORF87 gene as a calcium binding protein with an EF-Hand motif. The EF-hand motifs are present in numerous calcium binding proteins, which exert a complex function in tumor growth and suppression. We show that the C1ORF87 gene is down-regulated in the lung and breast carcinomas and up-regulated in the liver carcinomas. Hematopoietic and neuronal tumors were largely negative. Its expression in select normal tissues suggests that the C1ORF87 may be a putative druggable gene. Our results suggest that the C1ORF 87 gene may play a significant role in specific carcinomas. We further demonstrate that the dark matter of the human proteome can be readily mined to predict putative cancer targets. Detailed characterization of the C1ORF87 gene will be presented. Citation Format: Ana Paula Delgado, Pamela Brandao, Sheilin Hamid, Wim Van de Ven, Ramaswamy Narayanan. Discovery of a novel carcinoma-associated EF hand containing protein by mining the dark matter of the human proteome. [abstract]. In: Proceedings of the 105th Annual Meeting of the American Association for Cancer Research; 2014 Apr 5-9; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2014;74(19 Suppl):Abstract nr 4189. doi:10.1158/1538-7445.AM2014-4189
THE ALTERNATIVE TO REVOLUTION
Authors: Glenn Frank
Journal: Annals of Internal Medicine (1934)

Article1 September 1934THE ALTERNATIVE TO REVOLUTIONGLENN FRANKGLENN FRANKSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-8-3-360 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe air is, at the moment, filled with premonitions of profound change in the political, social, and economic life of the United States.Many Americans are sincerely fearful that we may rush into changes that will bring our traditional order of private enterprise and political liberty to a decisive and disastrous end. And they see no matured alternative around which grave doubts do not swarm. These Americans have no personal or political axes to grind by the expression of this fear. Their concern is genuine.A few Americans, without this sincerity of concern, are attempting to further personal and partisan... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Madison, Wisconsin*Address at the banquet of the American College of Physicians, Chicago, April 19, 1934. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 September 1934Volume 8, Issue 3Page: 360-373KeywordsFear ePublished: 1 December 2008 Issue Published: 1 September 1934 PDF downloadLoading ...
Chronic obstructive pulmonary disease (COPD) and alterations of hemogram
Authors: Regina Hasa, Hasan Hafizi, Dafina Todri, Roland Hasa, Eritjan Tashi, Sofiela Telo
Journal: European Respiratory Journal (2014)

Background:  The aim of this study was to determine the values of hematological markers and some other biomarkers in patients with stable COPD in order to define the presence of anemia,degree of systemic inflammation and correlations between the analytes.   Methods:  We evaluated CBC, biochemical, bloodgas and spirometry studies performed in 87 COPD patients (FEV 1  = 50 ± 5.75%) and 17 control subjects (FEV 1  = 103 ± 10%). Pursuant to GOLD guidelines, the patients were divided into 4 subgroups and for hematology, into 3 subgroups: subjects with anemia, without anemia and those with slight polyglobulia.Mean age resulted 65.7(38-84). 68.3% of cases were smokers.27% of patients had cardiac diseases,16.3% were hypertensive subjects ,11.5% had secondary infections, 8% renal disease and 6% with DM typeII.   Results:  No significant differences were found in the values of RBC,HBG and Htc either between the group of all COPD patients and control subjects or between GOLD subgroups and control subjects.Anemia was present in 8% of the COPD cases ,mostly subjects with renal disease and secondary infection.Polyglobulia was mostly present in Stage III- IV COPD patients >70 years(28.7%). ES revealed good negative correlation with RBC, Hb and Htc (r= -0.7, r= -0.673,r= -0.679 respectively;p   Conclusion:  Inflammation and comorbidities induce hemogram changes in COPD patient. especially in last stages.
One hundred patients with acute leukemia treated by chemotherapy, total body irradiation, and allogeneic marrow transplantation
Authors: ED Thomas, CD Buckner, M Banaji, RA Clift, A Fefer, N Flournoy, BW Goodell, RO Hickman, KG Lerner, PE Neiman, GE Sale, JE Sanders, J Singer, M Stevens, R Storb, PL Weiden
Journal: Blood (1977)
An Atlas of Normal Radiographic Anatomy.
Authors: Isadore Meschan
Journal: Annals of Internal Medicine (1952)

This small volume is a very competent review of the published data on comparative physiology of the thyroid and parathyroid glands.It should be of interest to endocrinolo- gists and to investigators of thyroid and parathryoid func- tion.Dr. Fleischmann reviews the literature showing -how early in the cordates evidence can be found of thyroid
Abstract 1780: Use of Arteriotomy Closure Devices and the Risk of Vascular Complications: An Analysis of 227,879 Patients in the ACC-NCDR
Authors: Sameer K Mehta, Andrew D Frutkin, Sunil V Rao, Tracy Y Wang, David Dai, David J Cohen, Steven P Marso
Journal: Circulation (2007)

INTRODUCTION Arteriotomy closure devices (ACDs) are often used to achieve hemostasis after percutaneous coronary intervention (PCI). Whether ACDs reduce or increase vascular complications is contro...
Abstract 112: FTY720-P is a potent inhibitor of class I histone deacetylases that enhances histone acetylation, reactivates ERα expression, and increases hormonal therapeutic sensitivity of breast cancer
Authors: Nitai C. Hait, Dorit Avni, Akimitsu Yamada, Sheldon Milstien, Kazuaki Takabe, Sarah Spiegel
Journal: Cancer Research (2015)

Abstract Hormonal therapies, including ovarian ablation, ER antagonists, and aromatase inhibitors, are the standards of care for treatment of ERα positive breast cancer. However, development of resistance to hormone therapies in advanced breast cancer is a major obstacle. Moreover, estrogen receptor-α (ERα)-negative breast cancer is clinically aggressive and does not respond to conventional estrogen targeted therapies. Strategies that lead to re-expression of ERα could sensitize breast cancers to selective ER modulators. FTY720/Fingolimod, a sphingosine analog, is an FDA-approved pro-drug for treatment of multiple sclerosis that also has anticancer actions that are not yet well understood. We have now found that FTY720 is phosphorylated in breast cancer cells by nuclear sphingosine kinase 2 and accumulates there. Nuclear FTY720-P in turn is a potent inhibitor of class I histone deacetylases (HDACs) that enhances histone acetylations and gene expression independently of its known effects on canonical signaling through sphingosine-1-phosphate receptors. In ERα negative human and murine breast cancer cells, FTY720 reactivated expression of silenced ERα and sensitized them to tamoxifen. Moreover, oral administration of clinically relevant doses of FTY720 to mice bearing ERα negative syngeneic breast tumors also re-expressed ERα and increased therapeutic sensitivity to tamoxifen in vivo more potently than a known HDAC inhibitor. Our work suggests that FTY720 is a promising strategy for effective treatment of conventional hormonal therapy-resistant breast cancer and triple-negative breast cancer. Supported by NIH grant RO1CA061774 and the Department of Defense BCRP program award W81XWH-14-1-0086 (S. Spiegel). Citation Format: Nitai C. Hait, Dorit Avni, Akimitsu Yamada, Sheldon Milstien, Kazuaki Takabe, Sarah Spiegel. FTY720-P is a potent inhibitor of class I histone deacetylases that enhances histone acetylation, reactivates ERα expression, and increases hormonal therapeutic sensitivity of breast cancer. [abstract]. In: Proceedings of the 106th Annual Meeting of the American Association for Cancer Research; 2015 Apr 18-22; Philadelphia, PA. Philadelphia (PA): AACR; Cancer Res 2015;75(15 Suppl):Abstract nr 112. doi:10.1158/1538-7445.AM2015-112
Unreliability of Physician "Report Cards" to Assess Cost and Quality of Care
Authors: Lewis G. Sandy
Journal: JAMA (2000)

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