GLUCOSE-SULFAPYRIDINE; EXPERIMENTAL AND CLINICAL STUDIES
Authors: Herbert K. Ensworth, James Liebmann, Merton C. Lockhart, Norman Plummer
Journal: Annals of Internal Medicine (1941)

Article1 July 1941GLUCOSE-SULFAPYRIDINE; EXPERIMENTAL AND CLINICAL STUDIESHERBERT K. ENSWORTH, M.D., JAMES LIEBMANN, M.D., MERTON C. LOCKHART, PH.D., NORMAN PLUMMER, M.D.HERBERT K. ENSWORTH, M.D.Search for more papers by this author, JAMES LIEBMANN, M.D.Search for more papers by this author, MERTON C. LOCKHART, PH.D.Search for more papers by this author, NORMAN PLUMMER, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-15-1-52 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptWhen satisfactory oral therapy with sulfapyridine is impossible, or when it is desired rapidly to obtain high blood concentrations of the drug, parenteral administration is necessary. Sodium sulfapyridine may be used for this purpose, but may sclerose veins, or cause local necrosis from accidental extravasation. In the search for soluble forms of the drug, preparations of sulfapyridine in glucose solutions have been made. Blake and Haviland1were able to get 2 grams of sulfapyridine into solution in a liter of fluid containing equal parts of 5 per cent glucose in distilled water and physiological saline which had been brought to...Bibliography1. BLAKEHAVILAND FGJW: Sulfapyridine in pneumococcal, streptococcal and staphylococcal infections, Internat. Clin., 1939, iv, 1. Google Scholar2. BRATTONMARSHALL ACEK: New coupling component for sulfanilamide determination, Jr. Biol. Chem., 1939, cxxviii, 537. CrossrefGoogle Scholar3. TAYLORLOWELLADAMSSPRINGFINLAND FHFCMAWCM: A comparative study of the blood concentrations and urinary excretion of sulfapyridine and sulfanilamide after single doses of compounds administered by various routes, Jr. Clin. Invest. 1940, xix, 201. CrossrefGoogle Scholar4. FINLANDLOWELLSPRINGTAYLOR MFCWCFH: Parenteral sulfapyridine; the intravenous use of sodium sulfapyridine and a report of clinical and laboratory observations on the use of a glucose-sulfapyridine solution, ANN. INT. MED., 1940, xiii, 1105. Google Scholar5. LOWELLSPRINGFINLAND FCWCM: Bactericidal action of sodium sulfapyridine and of a glucose-sulfapyridine solution in human blood, Jr. Clin. Invest., 1940, xix, 215. CrossrefGoogle Scholar6. PLUMMERLIEBMANNSOLOMONKAMMERERKALKSTEINENSWORTH NJSWHMHK: Chemotherapy versus combined chemotherapy and serum in the treatment of pneumonia, Jr. Am. Med. Assoc., 1941, cxvi, 2366. CrossrefGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: New York, N. Y.*Received for publication December 10, 1940.From the First (Columbia) and Second (Cornell) Medical Divisions, Bellevue Hospital, the Departments of Medicine of the College of Physicians and Surgeons, Columbia University and Cornell University Medical College.The chemical and animal studies were done at the Lederle Laboratories (Dr. Lockhart).The clinical studies were conducted under a grant of the Josiah Macy, Jr. foundation.†A Schiff's base may be designated as the reaction product of an aldehyde with an amino group to form anils. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 July 1941Volume 15, Issue 1Page: 52-62KeywordsDrug administrationDrug therapyDrugsGlucoseHospital medicineNecrosisOral administrationSodiumSurgeonsVeins ePublished: 1 December 2008 Issue Published: 1 July 1941 PDF downloadLoading ...