tbuckley/cabot-search huggingface dataset:
The management of lower urinary tract symptoms in men
Authors: J. Rees, M. Bultitude, B. Challacombe
Journal: BMJ (2014)

Thank you for your interest in spreading the word about The BMJ.NOTE: We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail. We do not capture any email address. Username * Your Email * Send To * You are going to email the following The management of lower urinary tract symptoms in men Your Personal Message CAPTCHA This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
Social and Economic Factors in the Choice of Lung Cancer Treatment
Authors: E. R. Greenberg, C. G. Chute, T. Stukel, J. A. Baron, D. H. Freeman, J. Yates, R. Korson
Journal: New England Journal of Medicine (1988)

We reviewed 1808 hospital charts representing virtually all patients given a diagnosis of non-small-cell lung cancer in New Hampshire and Vermont between 1973 and 1976 and found that the treatment of patients varied according to their marital status, medical insurance coverage, and proximity to a cancer-treatment center. Patients were more likely to be treated with surgery if they were married (odds ratio, 1.67; 95 percent confidence interval, 1.08 to 2.57) or had private medical insurance (1.52; 1.03 to 2.26). Among patients who did not have surgery, those with private insurance were more likely to receive another form of anticancer therapy--either radiation or chemotherapy (1.57; 1.18 to 2.09). Residing farther from a cancer-treatment center was associated with a greater chance of having surgery. Patients 75 years of age and older were less likely to have surgery (0.16; 0.08 to 0.35) or any other tumor-directed therapy (0.32; 0.19 to 0.54). The relation between the type of treatment and a patient's characteristics was not based on apparent differences in tumor stage or functional status, although both these factors were also strongly predictive of the type of treatment. Despite the fact that privately insured and married patients were more aggressively treated, they did not survive longer after diagnosis. We conclude that for non-small-cell lung cancer, socio-economic as well as medical factors determine treatment.
Treatment of porphyria cutanea tarda with chloroquine and phlebotomy
Authors: GUNNAR SWANBECK, GORAN WENNERSTEN
Journal: British Journal of Dermatology (1977)

Treatment of porphyria cutanea tarda (PCT) with chloroquine risks serious side‐effects so we have combined it with phlebotomy. One to four venesections were performed before the administration of chloroquine in to PCT patients. Equally high excretion of urinary porphyrins was achieved but the side‐effects were reduced. Chloroquine may be used as a provocative diagnostic test for patients with a questionably latent PCT but this is safe is safe if phlebotomy is performed beforehand.
Effect of etanercept on matrix metalloproteinases and angiogenic vascular endothelial growth factor: a time kinetic study
Authors: A Aggarwal
Journal: Annals of the Rheumatic Diseases (2004)

Chronic synovitis in rheumatoid arthritis results in the formation of pannus that invades the joint cartilage and the underlying bone. Matrix metalloproteinases (MMPs) can degrade cartilage, bone, and connective tissue matrix.1 Of these matrix degrading enzymes, MMP-1 is the most important and is present in the synovial lining of patients with rheumatoid arthritis (RA).2 In synovial tissue, the level of tissue inhibitor of MMP (TIMP) is reduced, tilting the balance towards tissue destruction. The effect of soluble tumour necrosis factor receptor (sTNFr) on these mediators is not known, because the only study available had pooled data of patients treated with sTNFr alone and in combination with methotrexate.3

Angiogenesis is central to the maintenance of pannus and is controlled by many factors. Identification of vascular endothelial growth factor (VEGF) as the major angiogenic factor, demonstration of its presence in …
Idiopathic Ulcerative Esophagitis
Authors: Hart Achenbach, Joseph P. Lynch, Richard W. Dwight
Journal: New England Journal of Medicine (1956)

THIS is a report of an unusual case of ulcerative disease of the esophagus that began in the lower third, progressed over a period of months and finally involved the entire length of the esophagus. There was loss of much of the mucosa and destruction of the muscular coats in several places leading to stenosis and multiple perforations, which caused abscesses in the mediastinum and right lung. Complicating processes included: perianal abscesses and fistulas; erythema nodosum; migratory arthritis; pyoderma gangraenosum; splenomegaly; and hepatic dysfunction. These complications, the patient's youth and his rapid deterioration suggested ulcerative colitis, but ulcers were found . . .
Surma and lead poisoning.
Authors: S S Bakhshi
Journal: BMJ (1978)

3).This deals with the time of onset of local compared with distant recurrence and the effect of radiotherapy on the time of onset of local recurrence.The error, which we acknowledge and for which we should like to apologise, is to have excluded from the life-table analysis patients who did not have recurrence.We should like to present amended data, dealing with these points, derived from a further analysis.Firstly, the time to onset of local recurrence is slightly longer than that to distant metastasis.The actuarial relapse rates for local recurrence at 2, 4, and 6 years are 15%, 23%, and 270% respectively, while for distant recurrence the rates are 23%/, 36%O, and 40%.For both groups there was a constant
On Ca2+ sensitivity and the airways: not just any smooth muscle
Authors: J. P. T. Ward
Journal: European Respiratory Journal (2006)

One of the more difficult questions raised by our students is: “What purpose does bronchoconstriction serve? What is its evolutionary advantage?” The most common answer is that narrowing of the airways increases air velocity and shear, thus facilitating removal of materials in the lumen during cough. From a simplistic point of view, it is difficult to see how under other circumstances sustained bronchoconstriction can be anything but detrimental. This differs from vascular smooth muscle (VSM), where sustained vasoconstriction regulates tissue blood flow. Therefore, it should not be surprising if there are qualitative differences in the mechanisms underlying constriction in smooth muscles subserving different functions. In many cases, application of findings in VSM to the airways may not be appropriate, and could be misleading 1. Considering the prevalence and importance of asthma, however, the number of studies on the contractile mechanisms of airway smooth muscle (ASM) is far fewer than for VSM.

One area where investigations in ASM lag behind those in VSM concerns the control of Ca2+ sensitivity of the contractile apparatus. This is despite its potential relevance to asthma, as increased Ca2+ sensitivity may at least partly underlie hyperresponsiveness 2–4. Various factors affect the relationship between intracellular [Ca2+] ([Ca2+]i) and force generation, including modulation of mechanical plasticity 5, but within the contractile apparatus the major determinant is the balance between myosin light chain kinase (MLCK)-dependent phosphorylation of myosin light chain (MLC), and its dephosphorylation by MLC phosphatase (MLCP). It is currently believed that MLCP is primarily regulated via Rho kinase-mediated phosphorylation of its targeting sub-unit MYPT1, and protein kinase C (PKC)- and/or Rho kinase-mediated phosphorylation of the MLCP inhibitor CPI-17; both inhibit MLCP activity and increase Ca2+ sensitivity 4. Agonists increase Ca2+ sensitivity via …
Phase I Pharmacokinetic and Pharmacodynamic Study of Pazopanib in Children With Soft Tissue Sarcoma and Other Refractory Solid Tumors: A Children's Oncology Group Phase I Consortium Report
Authors: Julia L. Glade Bender, Alice Lee, Joel M. Reid, Sylvain Baruchel, Timothy Roberts, Stephan D. Voss, Bing Wu, Charlotte H. Ahern, Ashish M. Ingle, Pamela Harris, Brenda J. Weigel, Susan M. Blaney
Journal: Journal of Clinical Oncology (2013)

Pazopanib, an oral multikinase angiogenesis inhibitor, prolongs progression-free survival in adults with soft tissue sarcoma (STS). A phase I pharmacokinetic and pharmacodynamic study of two formulations of pazopanib was performed in children with STS or other refractory solid tumors.Pazopanib (tablet formulation) was administered once daily in 28-day cycles at four dose levels (275 to 600 mg/m(2)) using the rolling-six design. Dose determination for a powder suspension was initiated at 50% of the maximum-tolerated dose (MTD) for the intact tablet. Ten patients with STS underwent dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) scanning at baseline and 15 ± 2 days after initiation of pazopanib at the tablet MTD.Fifty-three patients were enrolled; 51 were eligible (26 males; median age, 12.9 years; range, 3.8 to 23.9 years). Hematologic and nonhematologic toxicities were generally mild, with dose-limiting lipase, amylase, and ALT elevation, proteinuria, and hypertension. One patient with occult brain metastasis had grade 4 intracranial hemorrhage. The MTD was 450 mg/m(2) for tablet and 160 mg/m(2) for suspension. Steady-state trough concentrations were reached by day 15 and did not seem to be dose dependent. One patient each with hepatoblastoma or desmoplastic small round cell tumor achieved a partial response; eight patients had stable disease for ≥ six cycles, seven of whom had sarcoma. All patients with evaluable DCE-MRI (n = 8) experienced decreases in tumor blood volume and permeability (P < .01). Placental growth factor increased, whereas endoglin and soluble vascular endothelial growth factor receptor-2 decreased (P < .01; n = 41).Pazopanib is well tolerated in children, with evidence of antiangiogenic effect and potential clinical benefit in pediatric sarcoma.
Post-Traumatic Knee Pain Leading to the Diagnosis of Spondyloarthropathy
Authors: Mojdeh Tofighi, Georges Baillet, Feyzi Tamgac, Patricia Thoreux, Pierre Weimann, Jean-Luc Moretti
Journal: Clinical Nuclear Medicine (2004)

The authors report a patient with persistent left knee pain after traumatic injury. The initial bone scan seemed to confirm a valgus stress knee injury. The final diagnosis, however, was focal inflammation of the knee ligaments (enthesopathy) related to ankylosing spondylitis. The diagnostic procedure and the results of other imaging modalities are presented. The bone scan findings are discussed.
Electronic responses: a newer, faster option for Drs Angry, Delighted and Disgruntled
Authors: Kamran Abbasi
Journal: Journal of the Royal Society of Medicine (2008)

My first policy on taking over editorship of the JRSM was to only consider online submissions. A few authors considered this decision to be unfair but the JRSM now only receives submissions via its electronic system, called Manuscript Central, which can be reached either directly (http://mc.manuscriptcentral.com/jrsm) or from the Journal's online homepage (www.jrsm.rsmjournals.com). Submissions are rising and the overwhelming majority of authors find their own way to the submission system without a nudge from me.
Abstract 3540: Overexpression of incrna h19 enhances development and metastasis of gastric cancer
Authors: Jiangfang Li, Hao Li, Liping su, Zheng-gang Zhu, Bingya Liu
Journal: Cancer Research (2014)

Abstract Background: Long non-coding RNAs (lncRNAs) have been shown to play key roles in the progression and metastasis in some carcinomas in recent studies. We found that the expression of long non-coding RNA H19 (H19) was much higher in gastric cancer tissues than that in paired noncanerous tissues. But its mechanism in gastric cancer remains unknown. The object of this study is to explore the role of H19 and it derived miR-675 in gastric cancer and to discover the downstream target genes. Methods: We detected the expression of H19 in 74 gastric tissues together with paired noncancerous tissues and followed-up median 27 months. Then, we investigated the role of H19 and miR-675 by knock-down their expression in MKN45 cell line and ectopic expression in SGC7901 cell line in vitro and in vivo. Finally, we built the co-expression network of H19 and demonstrate the target genes by RIP and DLR. Results: The overall survival (OS) in the patients with low H19 expression (ratio&amp;lt;6) is much longer than that with high H19 expression (ratio≥6). Overexpression of H19 can enhance the characteristics of gastric cancer cells such as proliferation, migration, invasion Tumor formation and metastasis. We built the co-expression network of H19 and demonstrated ISM1 was the binding protein of H19. The expression of ISM1 was positive correlated with that of H19. CALN1 was the target gene of miR-675. The expression of CALN1 was negative correlated with that of miR-675. Conclusion: Overexpression of H19 correlates with bad prognosis in gastric cancer. H19 acts as an oncogene in gastric cancer to enhance the proliferation, migration, invasion, and metastasis. MiR-675 also can enhance gastric cancer progression and metastasis. In additional, H19 RNA is actively bind to protein ISM1 however miR-675 targets the protein CALN1. These suggested that H19 effect on GC both through encoding miR-675 and up-regulation ISM1. Citation Format: Jiangfang Li, Hao Li, Liping su, Zheng-gang Zhu, Bingya Liu. Overexpression of incrna h19 enhances development and metastasis of gastric cancer. [abstract]. In: Proceedings of the 105th Annual Meeting of the American Association for Cancer Research; 2014 Apr 5-9; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2014;74(19 Suppl):Abstract nr 3540. doi:10.1158/1538-7445.AM2014-3540
Day Care for Cancer Patients
Authors: Else Ratkowski
Journal: JAMA (1974)

During the six years of its existence, the Hadassah University Hospital "day-care" unit has proved its value as an additional service of the Oncological Center. A total of 188 patients were treated by the service during a six-month observation period, with about 20 patient-visits each day. Sixty percent of the patients received chemotherapy. All reacted favorably to the service, which gave them the opportunity to extend their useful life. (<i>JAMA</i>230:430-431, 1974)
Peddling consumption over health: obesity and reality television
Authors: D. Spence
Journal: BMJ (2010)

The last time I watched much television, Kylie Minogue had a frizzy perm and was married to Jason Donavon, who sported a dreadful mullet, as I did, and we all drank Castlemaine XXXX. So much of modern television has passed me by—too busy working, changing nappies, and writing poorly constructed, rambling prose. But recently I have been watching The Biggest Loser USA .

To those unfamiliar with it, it features a group of morbidly obese Americans who attend a health ranch for several weeks. Of course, this seems like standard voyeuristic, cheap, exploitive reality television, used to sell cat food, horrible hot chocolate, and rotating leather effect sofas—and you would …
INHERITANCE OF HARELIP
Authors: Henri Vignes
Journal: JAMA (1931)

<h3>To the Editor:</h3> —InThe Journal, April 4, page 1169, appears the statement that harelip is not an inherited characteristic. Butcher and Hutchinson have reported cases of heredity of the deformity. Péron in his doctoral thesis presented before the Faculty of Medicine of Paris in 1929 discussed the frequency of congenital harelip and cleft palate and stated that the deformity is rarely an inherited characteristic, although there are certain instances in which the rôle played by inheritance cannot be denied.
Folic acid and the nervous system.
Authors: N. Gordon
Journal: BMJ (1969)

colleges, Ludhiana, takes in an equal number of men and women medical students, and for its 50 places this year had 2,400 applications, a steadily rising number over the paist six years.-Iam, etc., E. GERARD HOUSDEN.London S.W.19.Abbreviations SIR,-I should like to support most strongly the plea by
Dynamics of complement activation in aHUS and how to monitor eculizumab therapy
Authors: Marina Noris, Miriam Galbusera, Sara Gastoldi, Paolo Macor, Federica Banterla, Elena Bresin, Claudio Tripodo, Serena Bettoni, Roberta Donadelli, Elisabetta Valoti, Francesco Tedesco, Alessandro Amore, Rosanna Coppo, Piero Ruggenenti, Eliana Gotti, Giuseppe Remuzzi
Journal: Blood (2014)
Prioritizing testing of organic compounds detected as gas phase air pollutants: structure-activity study for human contact allergens.
Authors: R Johnson, O T Macina, C Graham, H S Rosenkranz, G R Cass, M H Karol
Journal: Environmental Health Perspectives (1997)

Organic compounds that are used or generated anthropogenically in large quantities in cities can be identified through their presence in the urban atmosphere and in air pollutant source emissions. Compounds identified by this method were screened to evaluate their potential to act as contact allergens. The CASE and MULTICASE computer programs, which are based on the detection of structure-activity relationships (SAR), were used to evaluate this potential. These relationships first are determined by comparing chemical structures to biological activity within a learning set comprised of 458 compounds, each of which had been tested experimentally in human trials for its sensitization potential. Using the information contained in this learning set, CASE and MULTICASE predicted the activity of 238 compounds found in the atmosphere for their ability to act as contact allergens. The analysis finds that 21 of 238 compounds are predicted to be active contact allergens (probability >0.5), with potencies ranging from mild to very strong. The compounds come from chemical classes that include chlorinated aromatics and chlorinated hydrocarbons, N-containing compounds, phenols, alkenes, and an S-containing compound. Using the measured airborne concentrations or emission rates of these compounds as an indication of the extent of their use, together with their predicted potencies, provides an efficient method to prioritize the experimental assessment of contact sensitization of untested organic compounds that can be detected as air pollutants.
Use of Polytetrafluoroethylene in Cardiac Surgery
Authors: Tetsuzo Akutsu
Journal: JAMA (1961)

<h3>To the Editor:—</h3> We are concerned by the fact that polytetrafluoroethylene (Teflon) is used by cardiac surgens to replace valve leaflets. Since polytetrafluoroethylene has been found strong and inert as aortic grafts, we made tricusp semilunar polytetrafluoroethylene valves and inserted them into dogs' hearts, 15 valves in mitral position (4 woven and 11 knitted), and one in the tricuspid area. Woven polytetrafluoroethylene is rather stiff, and the cut end frays easily. Knitted polytetrafluoroethylene is soft enough; however, immediately after insertion regurgitation through the porous cloth took place. Fortunately, the small holes were sealed with fibrin soon after the heparin was neutralized with polybrene. Initially, 7 dogs survived the operation, and were well and moving about. However, they all died 2 to 9 days later from the same cause, occlusion of the valves by thrombi. Apparently the thin layer of fibrin, found so beneficial in artificial aortas, is a liability on
Relationships of Lipoprotein Lipids to Mild Fasting Hyperglycemia and Diabetes in Pregnancy
Authors: Robert H Knopp, Margaret Chapman, Robert Bergelin, Patricia W Wahl, Maria R Warth, Susan Irvine
Journal: Diabetes Care (1980)

The available data have been examined to determine if plasma lipids or lipoproteins are altered in pregnant subjects with adult-onset (type II) diabetes, gestational diabetes, or the hyperglycemic extreme of a randomly selected group of pregnant women attending a prepaid health plan. In each of these groups, a trend is observed toward an increase in total plasma and very low density lipoprotein triglycerides and a decrease in high density lipoprotein (HDL) cholesterol. These observations indicate that measurements of plasma triglyceride and HDL cholesterol may be valuable in identifying and quantifying the metabolic abnormality in gestational diabetes and in prognosticating fetal outcome.
Studies of red cell stromal proteins in Tay-Sachs disease
Authors: John A. Balint, Emilios C. Kyriakides
Journal: Journal of Clinical Investigation (1968)

Hemoglobin-free red blood cell ghosts of nine patients with Tay-Sachs disease and 14 normal control subjects have been analyzed for content of total protein, hexosamines, individual amino acids, and sialic acid. Red cell ghosts from Tay-Sachs' children have been shown to contain significantly increased amounts of protein, hexosamine, threonine, and serine, and probably sialic acid, each of which was increased by approximately 25% over control values. These observations suggest that the red cell membrane in patients with Tay-Sachs disease contains a significant excess of a glycoprotein or proteins, as compared with normal, and that the metabolic defect in this disease, therefore, affects glycoproteins as well as complex lipids.
Unilateral Osteophytes Simulating Metastatic Lesions on Bone Scan
Authors: ROY D. SNABLE, MICHAEL M. McDANIEL, MORTIMER E. MORTON
Journal: Clinical Nuclear Medicine (1978)

SNABLE, ROY D. M.D.; McDANIEL, MICHAEL M. M.D.; MORTON, MORTIMER E. PhD., M.D. Author Information
Mutations in NOTCH2 cause Hajdu-Cheney syndrome, a disorder of severe and progressive bone loss
Authors: Michael A Simpson, Melita D Irving, Esra Asilmaz, Mary J Gray, Dimitra Dafou, Frances V Elmslie, Sahar Mansour, Sue E Holder, Caroline E Brain, Barbara K Burton, Katherine H Kim, Richard M Pauli, Salim Aftimos, Helen Stewart, Chong Ae Kim, Muriel Holder-Espinasse, Stephen P Robertson, William M Drake, Richard C Trembath
Journal: Nature Genetics (2011)
Guidelines warn psychiatrists about memory recovery techniques
Authors: D. Carlisle
Journal: BMJ (1997)

Psychiatrists in Britain have been advised not to use “memory recovery techniques” to unearth past sexual abuse of which the patient has no memory. But the Royal College of Psychiatrists has pulled back from publishing the report on which its new guidelines are based.

The guidelines follow concern over the “false memory syndrome,” in which patients recover memories of childhood sexual abuse under techniques such as hypnotherapy, regression therapy, and drug mediated interviews. The college says that these techniques are not acceptable in psychiatric practice, that …
NICE advises screening for TB in hostels and prisons to reduce UK cases
Authors: Z. Kmietowicz
Journal: BMJ (2012)

Commissioners of tuberculosis services need to adopt a more active approach to detecting the disease among hard to reach groups to help reduce the rate of infections, including screening at hostels for homeless people, prisons, and drug treatment centres, says the National Institute for Health and Clinical Excellence (NICE).

Multidisciplinary TB teams are needed to provide rapid access TB clinics for hard to reach groups throughout the year, says the guidance. The teams should include at least one TB case manager with responsibility for planning and coordinating the care for this group of people, as well as specialists in paediatrics, infection control, and respiratory medicine, 

Funds to provide transport to clinics, to provide incentives for treatment, or for paying staff to support …