The "Red Man's Syndrome" and Slow Infusion of Vancomycin
Authors: Robin L. Davis, Arnold L. Smith, Jeffrey R. Koup
Journal: Annals of Internal Medicine (1986)

Letters and Corrections1 February 1986The "Red Man's Syndrome" and Slow Infusion of VancomycinROBIN L. DAVIS, Pharm.D., ARNOLD L. SMITH, M.D., JEFFREY R. KOUP, Pharm.D.ROBIN L. DAVIS, Pharm.D.Search for more papers by this author, ARNOLD L. SMITH, M.D.Search for more papers by this author, JEFFREY R. KOUP, Pharm.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-104-2-285_2 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: Rapid infusion of vancomycin is associated with a potentially hazardous reaction known as the "red man's syndrome," characterized by a decrease in blood pressure that may or may not be accompanied by an erythematous rash over the face, neck, upper trunk, and upper arms (1-3). Initially, this reaction may be mistaken for an allergy, but infusions given over 30 to 60 minutes are usually well tolerated (2), even in persons who have had the reaction after more rapidly infused doses (1). This report describes five cases of the "red man's syndrome" that occurred during the slow administration...References1. GARRETTSPETERIE JS. Vancomycin and the "red man's syndrome" [Letter]. N Engl J Med. 1985;312:245. CrossrefGoogle Scholar2. NEWFIELDROIZEN PM. Hazards of rapid administration of vancomycin. Ann Intern Med. 1979;91:581. LinkGoogle Scholar3. ODIOMOHSSKLAR CEF. Adverse reactions to vancomycin used as prophylaxis for CSF shunt procedures. Am J Dis Child. 1984;138:17-9. MedlineGoogle Scholar4. PAUKHAKOO AR. "Red-neck syndrome" with slow infusion of vancomycin. N Engl J Med. 1985;313:756-7. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: University of Washington Seattle, WA 98195 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByRed man syndrome following the use of vancomycin-loaded bone cement in the primary total knee replacementVancomycinSample Cleanup Using Solid-Phase Dispersive Extraction for Determination of Vancomycin in SerumVancomycin therapeutics and monitoring: a contemporary approachRisque allergique en anesthésie pédiatriqueANTIBACTERIAL DRUGSMastocytoses et anesthésieVancomycinCombination therapy with polymyxin B-immobilized fibre haemoperfusion and teicoplanin for sepsis due to methicillin- resistant Staphylococcus aureusLes glycopeptidesAntihistamine prophylaxis permits rapid vancomycin infusionVancomycinProspective, double-blind, randomized trial of teicoplanin versus vancomycin for the therapy of vascular access-associated bacteremia caused by gram-positive pathogensOral Antihistamines Reduce the Side Effects from Rapid Vancomycin InfusionAntibiotics for treatment of infections caused by MRSA and elimination of MRSA carriage. What are the choices?Vancomycin hypersensitivity: Synergism with narcotics and ″desensitization” by a rapid continuous intravenous protocolAngioedema and Urticaria Associated With Omeprazole Confirmed by Drug RechallengeAdministration of vancomycin during cardiopulmonary bypassAbsence of "red man syndrome" in patients being treated with vancomycin or high-dose teicoplaninProphylactic Use of Antimicrobial Agents in Adult PatientsAdverse reactions to vancomycin prophylaxis in cardiac surgeryVancomycinTeicoplanin in perspectiveToxicities of Antimicrobial Agents Used to Treat OsteomyelitisRevised guidelines for the control of epidemic methicillin-resistant Staphylococcus aureusMonitoring home IV antibiotic therapyComparison of vancomycin- and teicoplanin-induced histamine release and "red man syndrome"Current Concepts in Prevention of Prosthetic Valve EndocarditisVancomycin-induced histamine release and "red man syndrome": comparison of 1- and 2-hour infusionsCardiovascular collapse and refractory bronchospasm following administration of vancomycin, esmolol, and heparinMethicillin-Resistant Staphylococcus aureusVancomycin, Ticarcillin, and Amikacin Compared with Ticarcillin-Clavulanate and Amikacin in the Empirical Treatment of Febrile, Neutropenic Children with CancerParesthesia and Back Pain in a Patient Receiving Vancomycin during HemodialysisProphylactic parenteral antibiotics in clean neurosurgical procedures: a reviewDelayed Red Neck Syndrome with Generic VancomycinProphylactic Use of Antimicrobial Agents in Adult PatientsMonitoring Vancomycin TherapyVancomycin: An Update 1 February 1986Volume 104, Issue 2Page: 285-286KeywordsAllergy and immunologyBlood pressureRashesVancomycin Issue Published: 1 February 1986 PDF DownloadLoading ...