tbuckley/cabot-search huggingface dataset:
Evolution pathways of IgE responses to grass and mite allergens throughout childhood
Authors: Adnan Custovic, Hans-Joachim Sonntag, Iain E. Buchan, Danielle Belgrave, Angela Simpson, Mattia C.F. Prosperi
Journal: Journal of Allergy and Clinical Immunology (2015)

Little is known about longitudinal patterns of the development of IgE to distinct allergen components.We sought to investigate the evolution of IgE responses to allergenic components of timothy grass and dust mite during childhood.In a population-based birth cohort (n = 1184) we measured IgE responses to 15 components from timothy grass and dust mite in children with available samples at 3 time points (ages 5, 8, and 11 years; n = 235). We designed a nested, 2-stage latent class analysis to identify cross-sectional sensitization patterns at each follow-up and their longitudinal trajectories. We then ascertained the association of longitudinal trajectories with asthma, rhinitis, eczema, and lung function in children with component data for at least 2 time points (n = 534).Longitudinal latent class analysis revealed 3 grass sensitization trajectories: (1) no/low sensitization; (2) early onset; and (3) late onset. The early-onset trajectory was associated with asthma and diminished lung function, and the late-onset trajectory was associated with rhinitis. Four longitudinal trajectories emerged for mite: (1) no/low sensitization; (2) group 1 allergens; (3) group 2 allergens; and (3) complete mite sensitization. Children in the complete mite sensitization trajectory had the highest odds ratios (ORs) for asthma (OR, 7.15; 95% CI, 3.80-13.44) and were the only group significantly associated with comorbid asthma, rhinitis, and eczema (OR, 5.91; 95% CI, 2.01-17.37). Among children with wheezing, those in the complete mite sensitization trajectory (but not other longitudinal mite trajectories) had significantly higher risk of severe exacerbations (OR, 3.39; 95% CI, 1.62-6.67).The nature of developmental longitudinal trajectories of IgE responses differed between grass and mite allergen components, with temporal differences (early vs late onset) dominant in grass and diverging patterns of IgE responses (group 1 allergens, group 2 allergens, or both) in mite. Different longitudinal patterns bear different associations with clinical outcomes, which varied by allergen.
Neutrophil chemotactic activity (NCA) in nasal secretions from atopic and nonatopic subjects
Authors: M. L. Kowalski, J. Grzegorczyk, M. Śliwinska‐Kowalska, B. Wojciechowska, M. Rożniecka, J. Rożniecki
Journal: Allergy (1993)

In order to elucidate the mechanism responsible for infiltration of nasal mucosa by granulocytes, we tested neutrophil chemotactic activity (NCA) in nasal lavages, by the modified Boyden chamber method, in 16 patients with perennial allergic rhinitis (AR), six ASA-sensitive patients with chronic rhinosinusitis (CRS), and seven normal, nonatopic control subjects (NC). Nasal secretions from all three groups showed significant NCA (mean 157.1 +/- 54.0, 62.2 +/- 20.7, and 39.4 +/- 11.4% of FMLP chemotactic activity for AR, CRS, and NC subjects, respectively). Nasal secretions from patients with AR expressed significantly higher NCA (P < 0.02) than did secretions from NA patients. NCA was unchanged by heating at 56 degrees C for 60 min and was not susceptible to degradation by trypsin. Nasal challenge with Dermatophagoides pteronyssinus antigen induced clinical symptoms and resulted in significant increases in total protein and albumin concentrations in nasal lavages in AR patients, but failed to change the mean NCA activity for up to 40 min after the challenge. These results indicate that nasal secretions from both atopic and nonatopic patients express NCA, but its relation to allergic inflammation remains to be established.
Abstract 3940: Activation of HER2 changes the cetuximab sensitivity in radioresisitant head and neck cancer cells
Authors: Jung J. Park, Sang Yoon Kim, Ji Hyun Seo, Hyo Won Chang, Roza Khalmuratova, Thomas E. Carey, Jin Pyeong Kim, Seung Hoon Woo
Journal: Cancer Research (2014)

Abstract Background: For patients with recurrent head and neck cancer after radiation therapy (RT), there are limited therapeutic selections. There is great interest in mechanisms of resistance to RT. To investigate these mechanisms, we established RT-resistant clones from head and neck squamous cell carcinoma (HNSCC) cells. Methods: To develop cell lines with acquired resistance to RT, we utilized the human HNSCC cell line AMC-HN3 and UDSCC-2. We irradiatied clinically relevant cumulative irradiation to cell lines and characterized for the molecular changes in the radioresistant lines relative to the parent cell lines. Results: A comparative analysis revealed that acquired resistance to RT was associated consistently with the overexpression of HER2 and cross-resistance to cetuximab. To examine the role of HER2, we knocked down HER2 in both radio-resistant and -sensitive parental cells and found an increase in sensitivity to cetuximab. Conversely, inhibition of HER2 in RT-resistant cells was sufficient in resensitizing them to cetuximab in vitro. Further studies indicated that HER2 may diminish sensitivity to cetuximab via activation of the phosphatidyl-inositol-3-kinase (PI3K)/AKT pathway. Conclusion: Taken together, these findings suggest a central role of HER2 in the development of acquired resistance to RT and prompt consideration to apply HER2 inhibition strategies in future clinical trials of recurrent HNSCC after RT. Citation Format: Jung Je Park, Sang Yoon Kim, Ji Hyun Seo, Hyo Won Chang, Roza Khalmuratova, Thomas E. Carey, Jin Pyeong Kim, Seung Hoon Woo. Activation of HER2 changes the cetuximab sensitivity in radioresisitant head and neck cancer cells. [abstract]. In: Proceedings of the 105th Annual Meeting of the American Association for Cancer Research; 2014 Apr 5-9; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2014;74(19 Suppl):Abstract nr 3940. doi:10.1158/1538-7445.AM2014-3940
Late luteal phase dysphoric disorder in young women
Authors: A D Rivera-Tovar, E Frank
Journal: American Journal of Psychiatry (1990)

The authors determined the prevalence of late luteal phase dysphoric disorder in 217 university women aged 17-29 years. Unaware of the focus on premenstrual syndrome (PMS), the participants rated DSM-III-R symptoms of late luteal phase dysphoric disorder over 90 days. Using a 30% or greater premenstrual change as an index of luteal variation, the authors found that 10 women (4.6%) met the symptom criteria during two menstrual cycles. Compared to 25 young women seeking treatment for PMS who met the same diagnostic criteria, the 10 women from the university sample reported significantly less fatigue and impaired concentration and somewhat less severe depression and overall symptoms.
A distinct gene close to the hairless locus on chromosome 8p underlies hereditary Marie Unna type hypotrichosis in a German family
Authors: S. Cichon, R. Kruse, A.M. Hillmer, G. Kukuk, M. Anker, K. Altland, M. Knapp, P. Propping, M.M. Nöthen
Journal: British Journal of Dermatology (2000)

Journal Article A distinct gene close to the hairless locus on chromosome 8p underlies hereditary Marie Unna type hypotrichosis in a German family Get access S. Cichon, S. Cichon Institute of Human Genetics, University of Bonn, Wilhelmstr. 31, 53111 Bonn, Germany Dr Sven Cichon.E‐mail: cichon@mailer.meb.uni‐bonn.de Search for other works by this author on: Oxford Academic Google Scholar R. Kruse, R. Kruse Institute of Human Genetics, University of Bonn, Wilhelmstr. 31, 53111 Bonn, GermanyDepartment of Dermatology, University of Düsseldorf, Moorenstr. 5, 40225 Düsseldorf, Germany Search for other works by this author on: Oxford Academic Google Scholar A.M. Hillmer, A.M. Hillmer Institute of Human Genetics, University of Bonn, Wilhelmstr. 31, 53111 Bonn, Germany Search for other works by this author on: Oxford Academic Google Scholar G. Kukuk, G. Kukuk Institute of Human Genetics, University of Bonn, Wilhelmstr. 31, 53111 Bonn, Germany Search for other works by this author on: Oxford Academic Google Scholar M. Anker, M. Anker Institute of Human Genetics, University of Bonn, Wilhelmstr. 31, 53111 Bonn, Germany Search for other works by this author on: Oxford Academic Google Scholar K. Altland, K. Altland Institute of Human Genetics, University of Giessen, Schlangenzahl 14, 35392 Giessen, Germany Search for other works by this author on: Oxford Academic Google Scholar M. Knapp, M. Knapp Institute for Medical Biometry, Informatics and Epidemiology, University of Bonn, Sigmund‐Freud‐Str. 25, 53105 Bonn, Germany Search for other works by this author on: Oxford Academic Google Scholar P. Propping, P. Propping Institute of Human Genetics, University of Bonn, Wilhelmstr. 31, 53111 Bonn, Germany Search for other works by this author on: Oxford Academic Google Scholar M.M. Nöthen M.M. Nöthen Institute of Human Genetics, University of Bonn, Wilhelmstr. 31, 53111 Bonn, Germany Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 143, Issue 4, 1 October 2000, Pages 811–814, https://doi.org/10.1046/j.1365-2133.2000.03781.x Published: 01 October 2000
The dexamethasone suppression test: identification of subtypes of depression
Authors: A F Schatzberg, A J Rothschild, J B Stahl, T C Bond, A H Rosenbaum, S B Lofgren, R A MacLaughlin, M A Sullivan, J O Cole
Journal: American Journal of Psychiatry (1983)

In this study mean 4 p.m. cortisol levels were significantly higher in patients with major depression than in control subjects or in patients with bipolar depression or dysthymic-related disorders. Moreover, the distribution of values differed significantly among groups. Eighteen of 45 patients with major depression had cortisol levels of 10 micrograms/dl or more, compared with 2 of 20 bipolar depressed patients and 0 of 31 controls. Patients with very high cortisol levels (15 micrograms/dl or more) tended to fulfill criteria for major depression with mood-congruent psychosis. The distribution of values in the major depression group also suggested the existence of three major subgroups. The authors discuss the implications of these data.
Nosocomial TB Control Guidelines Debated; Will OSHA's Proposed Regulations Prevail?
Authors: C Marwick
Journal: JAMA (2000)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Abstract P343: Using Semi-Parametric Models to Examine the Association Between Changes in Animal-Source and Fat Calories Over 18 Years With the Distribution of Hba1c in Chinese Adults
Authors: Samantha M Attard, Annie-Green Howard, Amy H Herring, Barry M Popkin, Penny Gordon-Larsen
Journal: Circulation (2015)

Background:  Most researchers assume a homogeneous association between diet behaviors and cardiovascular disease (CVD) risk factors like diabetes, despite the fact that individuals differ in susceptibility and unobserved characteristics.   Objective:  To assess whether distributional changes in dietary intake over time relate to current diabetes and whether initial diet status or changes in diet are comparatively more relevant for diabetes risk.   Methods:  With population-based data from 18,987 Chinese adults ages 18-75y seen up to 7 times between 1991 and 2009 in the China Health and Nutrition Survey, we derived diet components from three consecutive 24-hour recalls (linked to individualized recipes and Chinese nutrition facts panels) at each survey (% energy from fat [%fat] and % energy from animal-source foods [%animal-source]) in relation to HbA1c measured via fasting blood in 2009. We used sex-stratified, longitudinal growth mixture models with random effects and a skew-T distribution to model individual trajectories separately for each dietary component over 18 years, controlling for time-varying urbanization, age, income, and caloric intake. Then we used the intercepts and slopes from the diet trajectories to predict the distribution of HbA1c in 2009 in separate models.   Results:  Using longitudinal data and adjusting for time-varying covariates, the shape of the distributions of %animal-source calories and %fat calories became flatter and more positively skewed over 18 years of modernization, with an increasing proportion of the population at the higher ends of fat and animal-source food distributions over time. The slope of %fat calories over time was strongly associated with HbA1c (men: p   Conclusions:  Our novel, semi-parametric growth mixture models revealed that targeting %fat calories may be particularly relevant for diabetes prevention because there was a strong association between change in %fat and HbA1c, irrespective of initial %fat calorie levels. Addressing animal-source food consumption remains important for diabetes prevention.
THE PLACE OF THE ELECTROCARDIOGRAM IN CARDIAC DIAGNOSIS
Authors: F F ROSENBAUM
Journal: Annals of Internal Medicine (1951)

Article1 September 1951THE PLACE OF THE ELECTROCARDIOGRAM IN CARDIAC DIAGNOSISFRANCIS F. ROSENBAUM, M.D., F.A.C.P.FRANCIS F. ROSENBAUM, M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-35-3-542 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptINTRODUCTIONNearly 50 years have passed since Einthoven introduced the string galvanometer. The instrument has become less cumbersome and less complex, and its clinical application has become increasingly simple. Electrocardiography is now so much a part of standard medical practice that many physicians and laymen feel that no general medical examination is complete without an electrocardiogram. It is inevitable, with such wide usage, that electrocardiograms or their interpretations come into the hands of men who are insufficiently grounded in fundamental considerations in the field of electrocardiography. In consequence, many patients are given diagnoses and prognoses which are unjustified and which... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Milwaukee, Wisconsin*Presented at the Thirty-second Annual Session of the American College of Physicians, St. Louis, Mo., April 9, 1951.From the Department of Internal Medicine, Marquette University School of Medicine, and the Medical Service, Columbia Hospital, Milwaukee, Wisconsin. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byOBSERVER VARIATION IN REPORTS ON ELECTROCARDIOGRAMSLate Electrocardiographic Changes in Acute Myocardial Infarction—a Problem in DiagnosisRS-T Segment elevation in mid- and left precordial leads as a normal variantIATROGENIC HEART DISEASE*HARRY B. WEINBERG, M.D., F.A.C.P. 1 September 1951Volume 35, Issue 3Page: 542-554KeywordsElectrocardiographyHospital medicineMedical services ePublished: 1 December 2008 Issue Published: 1 September 1951 PDF downloadLoading ...
Abstract MP66: AREST Lifestyle: Adherence Effects of a Comprehensive Reminder System on Exercise Adherence in Post-Myocardial Infarction Patients
Authors: Avinash Pandey, Niteesh K Choudhry
Journal: Circulation (2015)

Background: The risk of recurrent cardiac events can be reduced by 30-50% through regular, structured exercise; however, there remains a high rate of inactivity in post myocardial infarction (MI) patients. Forgetting to exercise may be a contributor to inactivity. This study assessed the hypothesis that text message reminders may be an effective strategy to reduce forgetfulness and inactivity. Methods: In this one year, single center study, we recruited 50 cardiac rehabilitation patients within 2 weeks of their MI. Participants were randomized to usual care or to receive text message reminders 4 times daily which stated "Please remember to exercise 45 minutes today". The outcomes measured were the frequency and total duration of exercise (assessed by log books) and physical endurance/ aerobic fitness (assessed by exercise stress testing at months 1, 3 and 12). Results: Intervention and control patients had similar baseline characteristics with an average age of 64. In the control group, monthly duration of exercise fell from an average of 683 minutes over 17 days at month 1 to 416 minutes over 11 days at month 12. Patients randomized to text message reminders exercised 772 minutes over 18 days at month 1 and 794 minutes over 18 days in month 12 (p&lt;0.01 for duration of exercise, control versus intervention, month 12). Baseline aerobic fitness and cardiac endurance was similar between control and intervention groups. However, there was a significant improvement in aerobic fitness and cardiac endurance at month 12 with text reminders (7.4 versus 6.1 METS achieved month 12, p&lt;0.01). In all sub-groups analyzed this intervention significantly improved exercise adherence and fitness. Conclusions: In summary, this system improved frequency and duration of exercise, and objective measures of cardiac endurance and aerobic fitness. While this study was not designed to assess clinical outcomes, this text message reminder system represents a simple and scalable method for improving adherence to exercise regimens among post-MI patients.
Supportive Psychotherapeutic Techniques in Primary and Secondary Alexithymia
Authors: Hellmuth Freyberger
Journal: Psychotherapy and Psychosomatics (1977)

Other Types| February 16 2010 Supportive Psychotherapeutic Techniques in Primary and Secondary Alexithymia / Discussion Subject Area: Psychiatry and Psychology Hellmuth Freyberger Hellmuth Freyberger Department of Psychosomatics, Hannover Medical School, Hannover-Kleefeld Search for other works by this author on: This Site PubMed Google Scholar Psychother Psychosom (1977) 28 (1-4): 337–345. https://doi.org/10.1159/000287080 Article history Published Online: February 16 2010 Content Tools Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Facebook Twitter LinkedIn Email Tools Icon Tools Get Permissions Cite Icon Cite Search Site Citation Hellmuth Freyberger; Supportive Psychotherapeutic Techniques in Primary and Secondary Alexithymia / Discussion. Psychother Psychosom 31 December 1977; 28 (1-4): 337–345. https://doi.org/10.1159/000287080 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAll JournalsPsychotherapy and Psychosomatics Search Advanced Search This content is only available via PDF. 1977Copyright / Drug Dosage / DisclaimerCopyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher.Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. Article PDF first page preview Close Modal You do not currently have access to this content.
Clarence Walton Lillehei John Andrew John Aubrey Luther Bonnell Kenyon Carnarvon Brown Stuart Charles Kennedy Harold Oliver Phillipson Ephraim Frank Swift Alfred Butler Taylor Michael Richard Tomlinson
Authors: N. Shumway, C J Earl, W M Dixon, K C Brown, M. Middleton, P. H Phillipson, D. Watt, R. Marcus, T. Pick, J. Fricker
Journal: BMJ (1999)