tbuckley/cabot-search huggingface dataset:
Health-Related Quality of Life and Health-Adjusted Life Expectancy of People With Diabetes in Ontario, Canada, 1996–1997
Authors: Douglas G. Manuel, Susan E. Schultz
Journal: Diabetes Care (2004)

To estimate the burden of illness from diabetes using a population health survey linked to a population-based diabetes registry.Measures of health-related quality of life (HRQOL) from the 1996/97 Ontario Health Survey (n = 35,517) were combined with diabetes prevalence and mortality data from the Ontario Diabetes Database (n = 487,576) to estimate the impact of diabetes on life expectancy, health-adjusted life expectancy (HALE), and HRQOL.Life expectancy of people with diabetes was 64.7 and 70.7 years for men and women, respectively-12.8 and 12.2 years less than that for men and women without diabetes. Diabetes had a large impact on instrumental and basic activities of daily living, more so than on functional health. HALE was 58.3 and 62.7 years, respectively, for men and women-11.9 and 10.7 years less than that of men and women without diabetes. Eliminating diabetes would increase Ontario life expectancy by 2.8 years for men and 2.6 years for women; HALE would increase by 2.7 and 3.2 years for men and women, respectively.The burden of illness from diabetes in Ontario is considerable. Efforts to reduce diabetes would likely result in a "compression of morbidity." An approach of estimating diabetes burden using linked data sources provides a robust approach for the surveillance of diabetes.
Introduction to Supportive Psychotherapyby Arnold Winston, M.D., Richard N. Rosenthal, M.D., and Henry Pinsker, M.D., series editor Glen O. Gabbard, M.D. Arlington, Va., American Psychiatric Publishing, 2004, 180 pp., $35.95.
Authors: ROGER PEELE, MARYAM RAZAVI
Journal: American Journal of Psychiatry (2006)
Open-Label Trial of Riluzole in Generalized Anxiety Disorder
Authors: Sanjay J. Mathew, Jonathan M. Amiel, Jeremy D. Coplan, Heidi A. Fitterling, Harold A. Sackeim, Jack M. Gorman
Journal: American Journal of Psychiatry (2005)

OBJECTIVE: There is a need to identify novel pharmacotherapies for anxiety disorders. The authors examined the safety and efficacy of riluzole, an antiglutamatergic agent, in adult outpatients with generalized anxiety disorder. METHOD: In an 8-week, open-label, fixed-dose study, 18 medically healthy patients with DSM-IV generalized anxiety disorder received treatment with riluzole (100 mg/day) following a 2-week drug-free period. The primary efficacy measure was the Hamilton Anxiety Rating Scale (HAM-A) score at endpoint. RESULTS: Twelve of the 15 patients who completed the trial responded positively to riluzole. At 8 weeks, eight of the 15 patients had HAM-A score indicating remission of their anxiety. The median time to response was 2.5 weeks. CONCLUSIONS: Riluzole appears to be an effective, well-tolerated, and rapidly acting anxiolytic medication for some patients with generalized anxiety disorder. Larger, placebo-controlled studies are indicated.
Is the Course of Panic Disorder the Same in Women and Men?
Authors: Kimberly A. Yonkers, Caron Zlotnick, Jenifer Allsworth, Meredith Warshaw, Tracie Shea, Martin B. Keller
Journal: American Journal of Psychiatry (1998)

OBJECTIVE: Panic disorder with or without agoraphobia has a chronic relapsing course. Factors associated with poor outcome include early onset of illness and phobic avoidance. Several, but not all, authors have found a worse clinical course for women. Using observational, longitudinal data from the Harvard/Brown Anxiety Disorders Research Program, the authors analyzed remission and symptom recurrence rates in panic patients with respect to sex. METHOD: Male and female patients (N=412) in an episode of panic with or without agoraphobia were assessed by structured interview and prospectively followed for up to 5 years. Data on remission, symptom recurrence, and comorbid psychiatric conditions for each sex were compared. RESULTS: There were no significant differences between men and women in panic symptoms or level of severity at baseline. Women were more likely to have panic with agoraphobia (85% versus 75%), while men were more likely to have uncomplicated panic (25% versus 15%). The rates of remission for panic with or without agoraphobia at 5 years were equivalent in men and women (39%). Of the subjects who achieved remission, 25% of the women and 15% of the men reexperienced symptoms by 6 months. Recurrence of panic symptoms continued to be higher in women (82%) than men (51%) during the follow-up period and was not influenced by concurrent agoraphobia. CONCLUSIONS: This study extends previous findings by showing that not only are women more likely to have panic with concurrent agoraphobia, but they are more likely than men to suffer a recurrence of panic symptoms after remission of panic.
Fordyce spots responding to isotretinoin therapy
Authors: B. E. Monk
Journal: British Journal of Dermatology (1993)

Journal Article Fordyce spots responding to isotretinoin therapy Get access B. E. Monk B. E. Monk Department of Dermatology Bedford Hospital, Bedford MK42 9DJ, U.K. Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 129, Issue 3, 1 September 1993, Page 355, https://doi.org/10.1111/j.1365-2133.1993.tb11874.x Published: 01 September 1993
Identifying relevant studies for systematic reviews
Authors: C. Counsell, H. Fraser
Journal: BMJ (1995)

EDITOR,—We agree with Kay Dickersin and colleagues' recommendations regarding the need for improved reporting of randomised controlled trials by authors and improved indexing of such trials in electronic databases.1 We wish to make two additional points on the basis of our experience of searching for randomised controlled trials related to stroke.

Firstly, there is a need for improved indexing in Medline (and other databases) of the medical subjects as well as the terms used …
Ultrasound guidance of Palmaz-Schatz intracoronary stenting with a combined intravascular ultrasound balloon catheter.
Authors: H Mudra, V Klauss, R Blasini, M Kroetz, J Rieber, E Regar, K Theisen
Journal: Circulation (1994)

Coronary stenting in conjunction with coronary angioplasty is a valuable tool for treatment of severe coronary dissection and is effective in reducing the frequency of restenoses. Evidence is increasing that the lumen gain within the stent is negatively correlated with the rate of subacute closures and restenoses. Since the assessment of radiolucent coronary stents and complex lumen morphologies by angiography is limited, we hypothesized that the use of a balloon catheter with integrated intravascular ultrasound (IVUS) facility for stent deployment and guidance of its expansion could improve the acute lumen gain without relevant procedural prolongation.Deployment of a single Palmaz-Schatz coronary stent with the combined imaging balloon catheter alone was successful in 18 of 20 patients eligible for this study. Corresponding measurements of minimal lumen diameter (MLD) by angiography and IVUS could be performed in 16 patients, revealing a close correlation between the two methods within the reference segments (3.10 +/- 0.38 and 3.08 +/- 0.43 mm, r = .79). Despite an adequate angiographic result in most patients after stent deployment, IVUS showed smaller MLD within the stented segment (2.15 +/- 0.23 mm) compared with angiography (2.63 +/- 0.26 mm, P < .0001) with a poor correlation (r = .27). To achieve IVUS criteria for optimal stent expansion (ratio of 0.9 between IVUS-assessed cross-sectional area of stent and reference segment), an average of three additional balloon inflations with higher pressure and/or a larger balloon diameter were performed without adverse effects in 15 of 16 patients who initially did not fulfill these criteria. This resulted in a significant increase in stent MLD to 2.63 +/- 0.27 mm (IVUS, P < .0001 versus initial MLD) and 2.89 +/- 0.32 mm (angiography, P < .0002 versus initial MLD) and a better correlation between the two methods (r = .60). The IVUS guidance led to a 40 +/- 15% increase of the minimal stent cross-sectional area with an additional time consumption of 21 minutes on average.This study demonstrates the application of a combined imaging balloon catheter for delivery and ultrasound-guided expansion of Palmaz-Schatz coronary stents. IVUS offered a comprehensive insight into the stented coronary segments, revealing a substantial overestimation of stent dimensions by angiography. IVUS guidance led to a significant improvement of stent expansion. This additional lumen gain, which was not discernible by angiography in most patients, might result in a reduction of subacute stent thromboses as well as restenoses.
Occupational Toxic Factor in Mortality from Coronary Heart Disease
Authors: J. R. Tiller, R. S. F. Schilling, J. N. Morris
Journal: BMJ (1968)

Between 1933 and 1962 42% of 223 deaths of male workers exposed to carbon disulphide in three viscose rayon factories in England and Wales were certified to coronary heart disease-compared with 24% of the deaths in the other workers of the same age, 17% of the deaths in other local men, and 14% in the Registrar General's Tables. Of men with more than 10 years in the rayon industry employed in one of the factories, those exposed to carbon disulphide had death rates from coronary heart disease between 1950 and 1964 two and a half times that of the other workers.This evidence of an occupational risk of coronary heart disease from long-term exposure to low concentrations of CS(2) was strongest in the 1940s and slight in 1958-62, and it may relate to wartime plant conditions. Current and prospective biochemical and morbidity surveys of exposed workers are now needed. These may also throw light on general issues of atherosclerosis and coronary heart disease.
Utility of the Neutrophil to Lymphocyte Ratio in Predicting In-hospital Mortality in Patients That Received Levosimendan Treatment for Acute Decompensated Heart Failure
Authors: Abdurrahman Tasal, Ozgur Surgit, Ahmet Bacaksiz, Omer Goktekin, Huseyin Uyarel, Mehmet Ergelen, Ercan Erdogan, Seref Kul, Osman Sonmez, Murat Turfan, Sitki Kucukbuzcu, Mehmet Akif Vatankulu, Aylin Hatice Yamac
Journal: Journal of the American College of Cardiology (2013)
CLINICAL NOTES ON LICHEN PLANUS.Read in the Section of Dermatology and Syphilography, at the Forty-second Annual Meeting of the American Medical Association, held at Washington, D. C., May, 1891.
Authors: L. DUNCAN BULKLEY
Journal: JAMA (1891)

Although lichen planus is one of the more rare diseases of the skin, it is one which occurs frequently enough to warrant the general practitioner being well acquainted with its natural history and therapeutics, while the very considerable suffering sometimes caused by the eruption, and its occasional rebelliousness to remedies, demand a further study from the specialist in regard to its nature and treatment. It is with a view of aiding in both these directions, that I have ventured to bring before this Association the experience which I have had with the disease during the past twenty years. Erasmus Wilson was the first to call attention to lichen planus, over twenty years ago, and his description of the eruption was so clear and graphic that it was at once recognized, especially in this country and England, and has long found a place in most dermatological classifications; and repeated reports on
The effect of interferon-gamma on the invasiveness of HT-180 cells
Authors: C.G. SCHIRREN, S. MAJEWSKI, N. HUNZELMANN, M. HECKMANN, T. KRIEG
Journal: British Journal of Dermatology (1992)

Journal Article The effect of interferon‐gamma on the invasiveness of HT‐180 cells Get access C.G. SCHIRREN, C.G. SCHIRREN Department of Dermatology, Ludwig‐Maximilians‐Universität Munchen, Germany Department of Dermatology, Universität Köln, Germany Search for other works by this author on: Oxford Academic Google Scholar S. MAJEWSKI, S. MAJEWSKI Department of Dermatology, Ludwig‐Maximilians‐Universität Munchen, Germany Department of Dermatology, Universität Köln, Germany Search for other works by this author on: Oxford Academic Google Scholar N. HUNZELMANN, N. HUNZELMANN Department of Dermatology, Ludwig‐Maximilians‐Universität Munchen, Germany Department of Dermatology, Universität Köln, Germany Search for other works by this author on: Oxford Academic Google Scholar M. HECKMANN, M. HECKMANN Department of Dermatology, Ludwig‐Maximilians‐Universität Munchen, Germany Department of Dermatology, Universität Köln, Germany Search for other works by this author on: Oxford Academic Google Scholar T. KRIEG T. KRIEG Department of Dermatology, Ludwig‐Maximilians‐Universität Munchen, Germany Department of Dermatology, Universität Köln, Germany Professor T.Krieg, Dermatologische Klink und Poliklinik der Universität Köln, Joseph Stelzmann Str 9, D‐5000 Köln‐41, Germany. Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 126, Issue 4, 1 April 1992, Pages 331–336, https://doi.org/10.1111/j.1365-2133.1992.tb00674.x Published: 01 April 1992
Biomedical Research Policy — A New Inquiry Begins
Authors: Daniel S. Greenberg
Journal: New England Journal of Medicine (1975)

Awash as it is with grievances, tensions, and unfunded but laudable grant applications, the health-research community ought to take note and advantage of a little-publicized matter: on January 31, a presidentially appointed, seven-member panel came into being to conduct a 15-month inquiry into the biomedical and behavioral research programs of the Department of Health, Education, and Welfare.There is, of course, no sparsity of past probings in this field. Contending parties around the agencies most directly involved — the National Institutes of Health and the Alcohol, Drug Abuse, and Mental Health Administration — are veteran practitioners of the bureaucratic rite . . .
Trace Elements and Blood Pressure
Authors: PAUL SALTMAN
Journal: Annals of Internal Medicine (1983)

Essential trace elements such as zinc, iron, and copper participate in various enzyme reactions directly related to the regulation of blood pressure and indirectly related to generation of oxidative metabolic energy, alterations in blood lipid levels, and alterations in taste acuity. The toxicological action of several heavy metal ions including cadmium, lead, mercury, and thallium can cause hypertension by affecting hormone metabolism, vasoconstriction, and renal tubular function. We conclude, however, that neither deficiencies of essential elements nor the presence of toxic heavy metals are primary causes of hypertension in our population.
SOLAR URTICARIA..
Authors: I. ANDERSON
Journal: British Journal of Dermatology (1951)

Journal Article SOLAR URTICARIA.: (Wave‐Length Less Than 3700Å.) Get access I. ANDERSON, B.Sc., M.B., M.R.C.P. I. ANDERSON, B.Sc., M.B., M.R.C.P. Senior Registrar to the Rupert Hallam Department of Dermatology, Royal Infirmary, Sheffield Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 63, Issue 6, 1 June 1951, Pages 230–233, https://doi.org/10.1111/j.1365-2133.1951.tb13718.x Published: 01 June 1951
Stem Cell Transplants Found Superior
Authors: Joan Stephenson
Journal: JAMA (2000)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
THE FUNCTIONAL CAPACITY OF HYPERTROPHIED NEPHRONS
Authors: Ashton B. Morrison, Ruth M. Howard
Journal: The Journal of Experimental Medicine (1966)

A method is described for the measurement of inulin and PAH clearances in rats without killing the animal. Inulin clearance measurements of partially nephrectomized rats and sham-control rats were made before operation and at intervals following the operation; inulin clearances were determined on normal rats at intervals during their growth. In another series of partially nephrectomized rats and their sham-operated controls, inulin and PAH clearances were determined in all the animals before and at intervals following the operation. Glomerular counts were made in some rats. After partial nephrectomy the inulin clearance is reduced but not as much as would be expected considering the amount of renal tissue removed. The mean inulin clearance per nephron is greatly increased in the partially nephrectomized rat when compared to the value determined for the control rat. The inulin clearance of the partially nephrectomized rat shows a progressive decline which is first clearly evident about 6 months after operation. The sham-operated rats showed an inulin clearance slightly less than that of nonoperated controls about 24 to 30 wk after the operation. In the normal rats the inulin clearance relative to body weight is much greater in rats with a mean weight of 197 +/- 3 g than in normals which are older and heavier. The PAH dearance of the partially nephrectomized rat is reduced following operation but undergoes no further change in the ensuing 24 wk.
Factor VIII Nomenclature
Authors: JOHN B. GRAHAM
Journal: Annals of Internal Medicine (1975)

Comments and Correction1 November 1975Factor VIII NomenclatureJOHN B. GRAHAM, M.D.JOHN B. GRAHAM, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-83-5-737_2 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: A task force has recommended to the International Committee on Thrombosis and Haemostasis the adoption of a new nomenclature for the "factor-VIII-related-activities." An "on-the-line" system of nomenclature has been recommended for the three major classes of activities related to blood coagulation factor VIII, that is VIII:C (for the coagulant activity), VIIIR:AG (for the antigenic activities related to factor VIII), and VIIIR: WF (for the "von Willebrand factor" activities related to factor VIII).Adoption of these recommendations, which are at present before the International Committee, will be deferred for at least 1 year while the task force receives... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Department of Pathology School of Medicine University of North Carolina Chapel Hill, North Carolina 27514 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 November 1975Volume 83, Issue 5Page: 737-737KeywordsAntigensBlood coagulationThrombosis Issue Published: 1 November 1975 PDF DownloadLoading ...
Advancing Research on Spiritual Influences at the End of Life Comment on “Provision of Spiritual Support to Patients With Advanced Cancer by Religious Communities and Associations With Medical Care at the End of Life”
Authors: Christopher G. Ellison, Maureen R. Benjamins
Journal: JAMA Internal Medicine (2013)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Internal Medicine HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Internal Medicine journal
Sulphamethoxypyridazine for dermatitis herpetiformis, linear IgA disease and cicatricial pemphigoid
Authors: J.P. McFADDEN, J.N. LEONARD, A.V. POWLES, A.J. RUTMAN, L. FRY
Journal: British Journal of Dermatology (1989)

Journal Article Sulphamethoxypyridazine for dermatitis herpetiformis, linear IgA disease and cicatricial pemphigoid Get access J.P. McFADDEN, J.P. McFADDEN Department of Dermatology, St Mary's Hospital, Praed Street, London W2, U.K. Dr J.McFadden. Search for other works by this author on: Oxford Academic Google Scholar J.N. LEONARD, J.N. LEONARD Department of Dermatology, St Mary's Hospital, Praed Street, London W2, U.K. Search for other works by this author on: Oxford Academic Google Scholar A.V. POWLES, A.V. POWLES Department of Dermatology, St Mary's Hospital, Praed Street, London W2, U.K. Search for other works by this author on: Oxford Academic Google Scholar A.J. RUTMAN, A.J. RUTMAN Department of Dermatology, St Mary's Hospital, Praed Street, London W2, U.K. Search for other works by this author on: Oxford Academic Google Scholar L. FRY L. FRY Department of Dermatology, St Mary's Hospital, Praed Street, London W2, U.K. Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 121, Issue 6, 1 December 1989, Pages 759–762, https://doi.org/10.1111/j.1365-2133.1989.tb08218.x Published: 01 December 1989
Injection of glycosylated recombinant simian IL-7 provokes rapid and massive T-cell homing in rhesus macaques
Authors: Stéphanie Beq, Sandra Rozlan, David Gautier, Raphaëlle Parker, Véronique Mersseman, Clémentine Schilte, Brigitte Assouline, Iann Rancé, Pascal Lavedan, Michel Morre, Rémi Cheynier
Journal: Blood (2009)
Chromosomal instability in ulcerative colitis is related to telomere shortening
Authors: Jacintha N. O'Sullivan, Mary P. Bronner, Teresa A. Brentnall, Jennifer C. Finley, Wen-Tang Shen, Scott Emerson, Mary J. Emond, Katherine A. Gollahon, Alexander H. Moskovitz, David A. Crispin, John D. Potter, Peter S. Rabinovitch
Journal: Nature Genetics (2002)
Why Saying No to Patients in the United States Is So Hard
Authors: Norman Daniels
Journal: New England Journal of Medicine (1986)

If cost-containment measures, such as the use of Medicare's diagnosis-related groups (DRGs), involved trimming only unnecessary health care services from public budgets, they would pose no moral problems. Instead, such measures lead physicians and hospitals to deny some possibly beneficial care, such as longer hospitalization or more diagnostic tests, to their own patients — that is, at the "micro" level.1 Similarly, if the "macro" decision not to disseminate a new medical procedure, such as liver transplantation, resulted only in the avoidance of waste, then it would pose no moral problem. When is it morally justifiable to say no to beneficial . . .