tbuckley/cabot-search huggingface dataset:
Comparison of two-dimensional echocardiography with gated radionuclide ventriculography in the evaluation of global and regional left ventricular function in acute myocardial infarction
Authors: Richard E. van Reet, Miguel A. Quinones, Lawrence R. Poliner, Jean G. Nelson, Alan D. Waggoner, Donna Kanon, Sanford J. Lubetkin, Craig M. Pratt, William L. Winters
Journal: Journal of the American College of Cardiology (1984)
A RAPID METHOD FOR RIPENING STAINS
Authors: Lawrence W. Strong
Journal: JAMA (1913)

The awkward necessity of waiting several weeks for hematoxylin stains to ripen has led me to apply a method originally described by Balch for the ripening of Wright's stain. This consists of a freshly precipitated silver oxid which, when added to any hemalum solution or to any methylene blue solution, will polychromize it within a few minutes. A gram of silver nitrate dissolved in 50 c.c. of distilled water is treated with a dilute solution of sodium hydroxid, little by little, until no more brown precipitate of silver oxid appears. The fluid should be shaken after each addition in order to secure good flocculation. The precipitate is then washed thoroughly until it is free from alkali. This may be tested by litmus or phenolphthalein; but ten or a dozen washings will suffice. This silver oxid is added to the hemalum or the methylene blue solution, allowed to stand for
Papal policy, poverty, and AIDS: a reply
Authors: D. Worlock
Journal: BMJ (1990)

My thoughts also go to those who are lacking in that precious gift that is good health....I think of them all and say: do not lose hope.These words are addressed above all to victims of AIDS, called face to face with a challenge not only of the sickness but also the mistrust of a fearful society that instinctively turns away from them.I invite everyone to take up the tragic burden of these brethren of ours, and I exhort scientists and researchers to increase their efforts to find an effective treatment for this mysterious illness.May the concerted efforts of science and love find the hoped-for remedy.
Hot tea and increased risk of oesophageal cancer
Authors: D. C. Whiteman
Journal: BMJ (2009)

Allowing tea to cool for five minutes before drinking is advisable

In the linked case-control study (doi:10.1136/bmj.b929), Islami and colleagues assess the association between how people drink their tea and the risk of oesophageal squamous cell carcinoma.1

Cancers of the oesophagus kill more than 500 000 people worldwide each year, with the bulk of the disease occurring in discrete populations in Asia, Africa, and South America.2 3 Despite recent increases in the incidence of adenocarcinomas of the oesophagus in industrialised nations,4 5 the most common subtype of oesophageal cancer worldwide is oesophageal squamous cell carcinoma. Tobacco and alcohol are the main causal factors related to oesophageal squamous cell carcinoma in the West, but they are not implicated in non-Western populations that have very high rates of this disease. Nutritional deficiency,6 viral infection,7 and dietary toxins8 have all been postulated as causal factors, although none can fully explain the extraordinary excess of cases of oesophageal squamous cell carcinoma seen in these populations.



Reza Malekzadeh and other authors of this population based case-control study talk about the effect of tea drinking and oesophageal cancer in Golestan province, northern Iran 

An intriguing hypothesis is that repeated thermal injury to the oesophageal epithelium may …
Remarks by the Secretary of Defense to the Massachusetts Medical Society, May 19, 1982
Authors: Caspar W. Weinberger
Journal: New England Journal of Medicine (1982)

I greatly appreciate and am honored by your invitation to give the Shattuck Lecture this year. The generosity and public-spiritedness of Dr. George Cheyne Shattuck, the benefactor of these lectures, and the distinguished speakers who have kept this traditon since 1890 make this invitation an unusual and — to me — surprising honor.I would like to talk today about a matter that concerns all of us equally: That is the threat of nuclear war, which all of us, to our dismay, have lived with now for some 34 years. This is a most disagreeable and difficult subject, but I . . .
LUPUS ERYTHEMATOSUS.-AN EXAMINATION OF THE NOTES OF FIFTEEN CONSECUTIVE CASES
Authors: WILFRID B. WARDE
Journal: British Journal of Dermatology (1902)

Journal Article LUPUS ERYTHEMATOSUS.—AN EXAMINATION OF THE NOTES OF FIFTEEN CONSECUTIVE CASES Get access WILFRID B. WARDE, M.D., M.R.C.P. WILFRID B. WARDE, M.D., M.R.C.P. Assistant Physician to the Hospital for Diseases of the Skin, Blackfriars Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 14, Issue 10, 1 October 1902, Pages 380–387, https://doi.org/10.1111/j.1365-2133.1902.tb16413.x Published: 01 October 1902
Medicare to test new option covering curative care for hospice patients
Authors: M. McCarthy
Journal: BMJ (2014)

Medicare, the US federal health insurance plan for elderly and disabled people, will test a new option for patients who want hospice care but also want to continue to receive care that seeks to achieve a cure.

Currently, Medicare patients who want to receive palliative care provided by hospices must forgo curative care.

Advocates for palliative care contend that this requirement makes many patients …
Author's reply to Rollin and Narula
Authors: J. Sheather
Journal: BMJ (2014)

We are struggling a little to identify Rollin and Narula’s genuine points of contention.1 2 We started from the position that questions about the allocation of public goods such as healthcare are political and matters for parliament. Our, surely unremarkable, next step was to suggest that some political decisions may generate conflict for professional ethics. The respondents imply, …
Small Transfusion, Severe Reaction
Authors: Thomas J. Degnan, Vyda Petzold, Allan Putterman
Journal: Annals of Internal Medicine (1973)

Letters1 March 1973Small Transfusion, Severe ReactionTHOMAS J. DEGNAN, M.D., F.A.C.P., VYDA PETZOLD, M.D., ALLAN PUTTERMAN, M.D.THOMAS J. DEGNAN, M.D., F.A.C.P.Search for more papers by this author, VYDA PETZOLD, M.D.Search for more papers by this author, ALLAN PUTTERMAN, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-78-3-452 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: We wish to report a severe hemolytic transfusion reaction from an extremely small amount of blood—specifically, 50 ml. The reaction was characterized by intravascular hemolysis, renal failure, and disseminated intravascular clotting; the latter was successfully treated with heparin.A 34-year-old white woman was admitted because of vaginal bleeding associated with an incomplete abortion. She was initially reported as having group A (negative) blood; transfusion of one unit of A negative compatible blood was begun. After receiving 50 ml, the patient became cyanotic and acutely dyspneic and complained of backache. The transfusion was stopped, and posttransfusion study showed...References1. WIENER A: Newer blood factors and their clinical significance. NY State J Med 54:3071-3077, 1954 MedlineGoogle Scholar2. SCHNEIDER C: Mechanism of production of acute fibrinogen deficiencies, in Progress in Hematology, vol. I, edited by TOCHANTINS LM. New York, Grune & Stratton, pp. 202-220 Google Scholar3. ROCKBOVENEMERSON RJR: Heparin treatment of intravascular coagulation accompanying hemolytic transfusion reactions. Transfusion 9:57-61, 1969 CrossrefMedlineGoogle Scholar4. MANNUCCILOBINACAOCCI PGL: Effect on blood coagulation of massive intravascular haemolysis. Blood 33: 207-213, 1969 CrossrefMedlineGoogle Scholar5. MOLLISON P: Blood Transfusion in Clinical Medicine, 4th ed. Philadelphia, F.A. Davis Co., 1967 Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Department of Medicine North Shore Hospital Manhasset, New York Department of Medicine Cornell University Medical College New York, New York PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByPitfalls in peripheral vascular surgery: Disseminated intravascular coagulation 1 March 1973Volume 78, Issue 3Page: 452-453KeywordsBlood groupsBlood transfusionHemorrhageHeparinLower back painRenal failure Issue Published: 1 March 1973 PDF DownloadLoading ...
Induction of IFN-regulated factors and antitumoral surveillance by transfected placebo plasmid DNA
Authors: Shulin Li, Miles Wilkinson, Xueqing Xia, Michael David, Lihong Xu, Amy Purkel-Sutton, Anjana Bhardwaj
Journal: Molecular Therapy (2004)

Delivery of DNA encoding therapeutic genes in vivo has great potential for treating malignancy as well as genetic diseases. Delivery of placebo DNA without a transgene is used as a control in gene therapy studies. It is tacitly assumed by most investigators that the protein expressed from the transfected DNA has phenotypic consequences, but that the consequences are not from the DNA itself. Here, we demonstrate that transfection of control plasmid DNA (that does not express a gene product) into tumor cell lines induces a dramatic (>10-fold) increase in the expression of the interferon (IFN)-regulated genes IRF7, STAT1, MIG (approved gene symbol CXCL9), MHCI (MICA), and CD11a (ITGAL) in tumor cell lines. Induction of these genes inhibits tumor development and tumor growth in immunocompetent mice that are immunized with apoptotic tumor cells. The antibody depletion study indicates that the underlying mechanism by which transfection of control DNA induces IFN-regulated genes is the induction of a secreting factor(s) such as IFN-beta. Three lines of evidence indicate that DNA transfection-mediated induction of IFN-regulatory genes is independent of TLR9. The three lines of evidence are: (1) TLR9 is not expressed in either SCCVII or 4T1 cell line, (2) activation of TLR9 downstream signaling molecules is not associated with the induction of gene expression, and (3) the secretion factor(s) obtained from the conditioned medium of DNA-transfected SCCVII tumor cells induces the same type of gene expression in the 4T1 tumor cell line, which is refractory to the gene induction by DNA transfection. Our finding indicates that the 4T1 tumor cell line, which is resistant to the DNA transfection-mediated induction of IFN-regulated genes, can be used to determine the real therapeutic gene function.
No Place for Politics
Authors: William R. Barclay
Journal: JAMA (1975)

The Advisory Committee on Medical Science to the American Medical Association is a group of distinguished scientists and physicians who have made notable contributions to medical knowledge. The committee consists of the following people: Philip H. Abelson, PhD, editor of Science magazine and president of Carnegie Institution of Washington; William G. Anlyan, MD, vice-president for health affairs, Duke University Medical Center; George E. Burch, MD, Department of Medicine, Tulane University School of Medicine; S. Richardson Hill, Jr., MD, vice-president for health affairs, University of Alabama Medical Center; Franz J. Ingelfinger, MD, editor,<i>New England Journal of Medicine</i>; Irvine H. Page, MD, editor,<i>Modern Medicine</i>; Prof Walter A. Rosenblith, provost, Massachusetts Institute of Technology; Keith P. Russell, MD, president, American College of Obstetricians and Gynecologists; L. Emmerson Ward, MD, chairman, Board of Governors, Mayo Clinic; and Dwight L. Wilbur, MD, past president, American Medical Association. They recently presented a report to
Encephalitogenicity Of "Siccacells"
Authors: Seymour Levine
Journal: JAMA (1968)

<h3>To the Editor:—</h3> Lyophilized animal brain tissues ("Trockenzellen" or "Siccacells") have been used therapeutically for a wide variety of conditions (<i>JAMA</i><b>172</b>:708, 1960; Schmid, F., and Stein, J.:<i>Zellforschung und Zellulartherapie</i>, Bern: Huber, 1963). This note summarizes the hazards of this therapy, with special reference to neuroallergic complications. The following data suggest that siccacell therapy is safe: Siccacells have been administered to thousands of patients with few major complications. Although injection of central nervous system tissues causes allergic encephalomyelitis in animals, the antigenicity of these tissues is so low that immunologic adjuvants (killed tubercle bacilli in oil, pertussis vaccine) are usually required to produce disease. We verified the above in primates. Large amounts (4 gm wet weight) of guinea pig spinal cord were injected intradermally at a single sitting, distributed among 50 sites, in each of four sooty mangabeys, two spiders, three stumptailed macaques, and two
Identification of Let-7–Regulated Oncofetal Genes
Authors: Benjamin Boyerinas, Sun-Mi Park, Noam Shomron, Mads M. Hedegaard, Jeppe Vinther, Jens S. Andersen, Christine Feig, Jinbo Xu, Christopher B. Burge, Marcus E. Peter
Journal: Cancer Research (2008)

MicroRNAs (miRNA) are small RNA molecules of approximately 20 to 22 nucleotides that reduce expression of proteins through mRNA degradation and/or translational silencing. Each known miRNA has a large number of predicted targets. Members of the let-7/miR-98 family of miRNAs are up-regulated at the end of embryonic development. Let-7 is often down-regulated early during cancer development, suggesting that let-7-regulated oncofetal genes (LOG) may become reexpressed in cancer cells. Using comparative bioinformatics, we have identified 12 conserved LOGs that include HMGA2 and IMP-1/CRD-BP. IMP-1 has growth-promoting activities through stabilization of c-myc mRNA. We experimentally confirmed that IMP-1 is a direct let-7 target that promotes cell growth and motility of tumor cells, and we confirmed by proteomics analysis that IMP-1 and HMGA2 are major miRNA targets. Our data suggest that a substantial part of the growth inhibitory activities of let-7 comes from suppressing the expression of IMP-1. LOGs could be novel therapeutic targets and potential biomarkers for cancer treatment.
Polymerase chain reaction-based clonality testing in tissue samples with reactive lymphoproliferations: usefulness and pitfalls. A report of the BIOMED-2 Concerted Action BMH4-CT98-3936
Authors: A W Langerak, T J Molina, F L Lavender, D Pearson, T Flohr, C Sambade, E Schuuring, T Al Saati, J J M van Dongen, J H J M van Krieken
Journal: Leukemia (2006)
Cutaneous vascular infarcts secondary to spontaneous platelet aggregation
Authors: None Lear, None Graham, None Pavord, None Mitchell, None Hutchinson
Journal: British Journal of Dermatology (1998)

We report a 23‐year‐old woman presenting with multiple cutaneous infarcts who was found to have spontaneous platelet aggregation (SPA). Her skin lesions showed a good response to aspirin therapy and platelet aggregation returned to normal. Subsequently, she was found to have and was treated for pulmonary tuberculosis. The SPA may have been related to this via the formation of immune complexes. Isolated cutaneous infarcts have not previously been described in association with SPA. The role of spontaneous and increased platelet aggregation in skin disorders is discussed.
Utility of real-time 3-D transthoracic echocardiography in the evaluation of mitral valve disease
Authors: Lissa Sugeng, Lynn Weinert, Yan Katsnelson, Neeraj Jolly, Kirk T. Spencer, Jeanne M. DeCara, Georgeanne Lammertin, James E. Bednarz, Karl Thiele, Roberto M. Lang
Journal: Journal of the American College of Cardiology (2003)
Failure of Intracoronary Nitroglycerin to Alleviate Pacing-Induced Angina
Authors: WILLIAM GANZ, HAROLD S. MARCUS
Journal: Circulation (1972)

Relief of angina by nitroglycerine has been attributed to two possible mechanisms: (1) Increase in myocardial blood supply by direct action of the drug on the coronary arteries. (2) Reduction in myocardial oxygen demand by action of the drug on the systemic circulation. Sublingual application of nitroglycerin in previous studies did not allow the ruling out of the operation of either or both mechanisms. This study was, therefore, designed in such a way that the effect of the direct action of nitroglycerin on the coronary bed on angina could be studied in the absence of changes in the systemic circulation. In 25 patients undergoing cardiac catheterization and coronary arteriography as possible candidates for revascularization surgery, nitroglycerin, 0.075 mg in 1 ml of 5% dextrose, was injected into the left coronary artery through the angiographic catheter during angina pectoris induced by pacing. Coronary sinus blood flow by the continuous thermodilution method, femoral artery blood pressure, and lead V 5 were recorded continuously. In 20 patients the procedure was repeated with injection into the right coronary artery. In none of the 25 patients did the intracoronary injection of nitroglycerin alleviate the angina during the 1-min observation period, whether injected into the obstructed artery or into the artery supplying collaterals to the obstructed artery. The intracoronary injection was ineffective despite a significant increase in coronary sinus blood flow in 14, lasting 26 sec on the average. This suggests that the increase in blood flow did not occur in the ischemic areas where it was needed, but in other areas where the arterioles were not maximally dilated by ischemia. This explanation is further supported by the fact that in five patients with very severe restriction of the left coronary artery system the coronary sinus blood flow failed to increase in response to intracoronary nitroglycerin during angina, but increased significantly in response to nitroglycerin after discontinuation of pacing and disappearance of angina. In six patients, 0.2 mg nitroglycerin injected intravenously 1 min following the intracoronary injection relieved the angina unaffected by the preceding intracoronary injection. The relief was associated with a fall in arterial blood pressure and coronary sinus blood flow. The study indicates that the direct action of nitroglycerin on the coronary bed plays little, if any, role in the antianginal effect of the drug, which appears to be due entirely to the action of the drug on the systemic circulation.
Reliability of psychiatric scales in patients with dementia of the Alzheimer type
Authors: G L Gottlieb, R E Gur, R C Gur
Journal: American Journal of Psychiatry (1988)

For 43 patients with probable Alzheimer's disease who were screened for psychiatric disorders, the interrater reliability of the Global Deterioration Scale, BPRS, and Hamilton Rating Scale for Depression was high (intraclass correlation, 0.82-0.998). As expected, the prevalence of psychiatric symptoms in this sample was low. The score on the Zung Self-Rating Depression Scale correlated with the score on the rater-administered Hamilton depression scale in patients whose Alzheimer's disease was of low severity (N = 24) but not high severity (N = 19).
A National Survey of Policies on Disclosure of Conflicts of Interest in Biomedical Research
Authors: S. Van McCrary, Cheryl B. Anderson, Jelena Jakovljevic, Tonya Khan, Laurence B. McCullough, Nelda P. Wray, Baruch A. Brody
Journal: New England Journal of Medicine (2000)

Conflicts of interest pose a threat to the integrity of scientific research. The current regulations of the U.S. Public Health Service and the National Science Foundation require that medical schools and other research institutions report the existence of conflicts of interest to the funding agency but allow the institutions to manage conflicts internally. The regulations do not specify how to do so.
Quality of Life in Cardiovascular Disease
Authors: Richard Mayou
Journal: Psychotherapy and Psychosomatics (1990)

Psychosomatic understanding of the consequences of cardiovascular disorders has had relatively little influence on the separate literature describing quality of life and evaluating interventions. This is partly because psychosomatic research has been too narrowly focussed but mainly because concepts and measures of quality of life take a limited view of its psychological aspects and neglect the significance of individual meaning. There is a need for more research which is based on carefully selected specific measures of quality of life chosen as being of particular importance to patients and to the hypotheses being tested. It is also essential to be aware of the wide range of individual response to cardiovascular disorders. Review of syndromes shows that there is considerable scope to improve understanding of the psychological aspects of quality of life and to develop and evaluate psychological interventions.
Resistance to activated protein C due to factor V Leiden mutation: high prevalence in patients with post-thrombotic leg ulcers
Authors: Y. Gaber, H-J. Siemens, W. Schmeller
Journal: British Journal of Dermatology (2001)

Activated protein C (APC) resistance is the most frequently diagnosed heritable thrombophilic defect predisposing to thrombosis.To determine the prevalence of APC resistance due to factor V Leiden mutation in patients with leg ulcers.Within a 2-year-period 100 consecutive patients with leg ulcers were examined for factor V Leiden mutation.APC resistance due to factor V Leiden mutation was detected in 19 of 53 patients (36%) with post-thrombotic leg ulcers and in three of 47 patients (6%) with ulcers caused by primary varicosis. In a healthy control group APC resistance due to factor V Leiden mutation was found in five of 96 (5%) volunteers.In view of this high prevalence of APC resistance of 36%, which has never previously been reported, patients with post-thrombotic leg ulcers should be investigated for APC resistance.
Continuing Medical Education: Perspectives, Problems, Prognosis
Authors: Hugh H. Hussey
Journal: JAMA (1978)

Richards's writing had its origin in his PhD dissertation (1975), which presumably has undergone extension and embellishment to reach book form. As a means of expressing his studies and expounding his ideas, the author uses force-field analysis—a term that probably will be unfamiliar to most readers. He explains the meaning twice, first in chapter 1 and later and more fully in a brief appendix where he tells that the use of a force-field process permits analysis of the interaction of driving and restraining forces. The greater part of Richards's book constitutes an excellent summary of the 20th-century reform and improvement of medical education at all levels, a progression that has been largely from within medicine and more recently influenced by a variety of governmental (state and federal) interventions. Scattered throughout the text are 14 well-executed tables that greatly reinforce the written material. Indeed, if a hurried reader were only to
Laboratory animal allergy
Authors: Robert K. Bush, Robert A. Wood, Peyton A. Eggleston
Journal: Journal of Allergy and Clinical Immunology (1998)

Approximately one third of laboratory animal workers have occupational allergy to animal danders, and a third of these have symptomatic asthma. Sensitization generally occurs with the first 3 years of employment, and risk factors include atopic background, as well as job description as it relates to the intensity of exposure. A symptomatic worker can reduce allergen exposure with personal protective devices. A laboratory can further reduce exposure with generally available equipment, such as laminar flow caging, and procedures, such as frequent wet washing of vivaria and careful maintenance of ventilation systems. It is advisable to institute periodic medical screening of all laboratory animal workers with questionnaires and allergy skin testing in addition to providing them with training programs to reduce personal exposure. (J Allergy Clin Immunol 1998;102:99-112.)