PENICILLIN-CARONAMIDE THERAPY OF ENTEROCOCCUS ENDOCARDITIS
Authors: R P HAGER, E J HEITZMAN, R M YOUNG
Journal: Annals of Internal Medicine (1951)

Case Reports1 February 1951PENICILLIN-CARONAMIDE THERAPY OF ENTEROCOCCUS ENDOCARDITISRUSSELL P. HAGER, Ph.D., M.D., EDWARD J. HEITZMAN, M.D., RAYMOND M. YOUNG, Ph.D.RUSSELL P. HAGER, Ph.D., M.D.Search for more papers by this author, EDWARD J. HEITZMAN, M.D.Search for more papers by this author, RAYMOND M. YOUNG, Ph.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-34-2-510 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptEnterococcus endocarditis has been shown to be particularly resistant to treatment. Of the unsuccessfully treated cases of bacterial endocarditis, the most frequent resistant organisms have been noted to be enterococci.1Clark, Bryner and Rantz2have stated that enterococci always tolerate higher penicillin concentrations than other streptococci, and although most species of streptococci occurring in this type infection are inhibited by 0.1 unit of penicillin per ml. of culture medium, the enterococci require over 0.5 unit and occasionally up to 50 to 100 units, the majority being inhibited by between 5 and 10 units. In order to attain therapeutic blood concentrations,...Bibliography1. SirotaGerberBaehr JHIEG: Chemotherapy of subacute enterococcus endocarditis, J. Mt. Sinai Hosp. 14: 604-617, 1947. MedlineGoogle Scholar2. ClarkBrynerRantz WHSLA: Penicillin-resistant nonhemolytic streptococcal subacute bacterial endocarditis, J. Med. 4: 671-689, 1948. CrossrefGoogle Scholar3. BrynerClarkRandallRantz SWHELA: Renal tubular excretory capacity for penicillin in health and subacute bacterial endocarditis, J. Med. 5: 202-209, 1948. CrossrefGoogle Scholar4. RammelkampBradley CHSE: Excretion of penicillin in man, Proc. Soc. Exper. Biol. and Med. 53: 30-32, 1943. CrossrefGoogle Scholar5. BeyerWoodwardPetersVerweyMattis KHRLWFPA: The prolongation of penicillin retention in the body by means of para-amino hippuric acid, Science 100: 107-108, 1944. CrossrefMedlineGoogle Scholar6. BronfenbrennerFavour JCB: Increasing and prolonging blood penicillin concentrations following intramuscular administration, Science 101: 673-674, 1945. CrossrefMedlineGoogle Scholar7. Beyer KH: New concept of competitive inhibition of the renal tubular excretion of penicillin, Science 105: 94, 1947. CrossrefMedlineGoogle Scholar8. CrossenBogerShawMiller JWWPCCKA: Enhancement of penicillin plasma concentration with caronamide, J. A. M. A. 134: 1528-1532, 1947. CrossrefMedlineGoogle Scholar9. SeelerWilcoxFinland AOCM: Enhancement of blood levels by caronamide during intramuscular administration of penicillin, J. Lab. and Clin. Med. 32: 807-817, 1947. Google Scholar10. StraussRichburgSabaAlexander EPLPZJE: Enhancement of plasma penicillin concentration by caronamide and sodium benzoate, J. Lab. and Clin. Med. 32: 818-831, 1947. Google Scholar11. KingSchneiersonSussmanJanowitzBlum FHSSMLHDL: A method for producing sustained high penicillin levels in the blood, Proc. Soc. Exper. Biol. and Med. 66: 548-551, 1947. CrossrefMedlineGoogle Scholar12. JanowitzSchneiersonSussmanKing HDSSMLFH: The role of high blood penicillin levels achieved with caronamide in penetrating the blood-brain barrier, J. Lab. and Clin. Med. 33: 933-935, 1948. MedlineGoogle Scholar13. RammelkampKeefer CHCS: Absorption, excretion and distribution of penicillin, J. Clin. Investigation 22: 425-437, 1943. CrossrefMedlineGoogle Scholar14. MacCallumHastings WGTW: A case of acute endocarditis caused by Micrococcus zymogenes with a description of the micro-organism, J. Exper. Med. 4: 521-534, 1899. CrossrefMedlineGoogle Scholar15. RapoportCornealBeyerVerwey MFBKHWF: A clinical evaluation in children of the toxicity and efficacy of caronamide (4-carboxyphenylmethane-sulfonanilide) for the competitive inhibition of penicillin excretion, Am. J. M. Sc. 215: 514-524, 1948. CrossrefMedlineGoogle Scholar16. Seeler AO: Prolonging the action of penicillin, Bull. New England M. Center 10: 56-62, 1948. MedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Providence, Rhode Island*Received for publication January 4, 1949.From the Medical Service, Rhode Island Hospital, Providence, Rhode Island. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byErkrankungen des EndokardTreatment of Bacterial Endocarditis 1 February 1951Volume 34, Issue 2Page: 510-516KeywordsAttentionBloodEndocarditisEnterococcusEnterococcus infectionsMedical servicesPenicillinStreptococcal infections ePublished: 1 December 2008 Issue Published: 1 February 1951 PDF downloadLoading ...