tbuckley/cabot-search huggingface dataset:
Hydroxyurea-Associated Leg Ulceration
Authors: Eddys Disla
Journal: Annals of Internal Medicine (1998)

Letters1 August 1998Hydroxyurea-Associated Leg UlcerationEddys Disla, MD, Louis D'Eamour, RN, and Michael Cioriou, MDEddys Disla, MDCabrini Wound Care Center; New York, NY 10003Search for more papers by this author, Louis D'Eamour, RNCabrini Wound Care Center; New York, NY 10003Search for more papers by this author, and Michael Cioriou, MDCabrini Wound Care Center; New York, NY 10003Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-129-3-199808010-00018 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:In their recent report, Best and colleagues [1] provide us with a fresh look at the association between leg ulcers and hydroxyurea therapy. Their conclusion that cessation of hydroxyurea therapy is necessary to achieve healing is nevertheless questionable. Because hydroxyurea is used to treat serious underlying systemic disorders, this approach is often impractical, as illustrated by a patient we recently treated at our wound care center.A 68-year-old man was referred with many painful, nonhealing ulcers that had been on his right leg for 1 year. The patient had a history of polycythemia vera, diagnosed in 1992, ...References1. Best PJ, Daoud MS, Pittelkow MR, Petitt RM. Hydroxyurea-induced leg ulceration in 14 patients. Ann Intern Med. 1998; 128:29-32. Google Scholar2. Hedner T. Calcium channel blockers: spectrum of side effects and drug interactions. Acta Pharmacol Toxicol. 1986; 58(Suppl 11):119-30. Google Scholar3. Nguyen TV, Margolis DJ. Hydroxyurea and lower leg ulcers. Cutis. 1993; 52:217-9. Google Scholar Author, Article, and Disclosure InformationAuthors: Eddys Disla, MD; Louis D'Eamour, RN; Michael Cioriou, MDAffiliations: Cabrini Wound Care Center; New York, NY 10003 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byEmerging Adverse Cutaneous Drug ReactionsUncommon leg ulcers in the lower extremityLeg ulcers in elderly on hydroxyurea: a single center experience in Ph− myeloproliferative disorders and review of literatureHydroxyurea-Induced Skin Ulcerations in Patients with Chronic Myeloproliferative DisordersHealing of an MRSA-colonized, hydroxyurea-induced leg ulcer with honey 1 August 1998Volume 129, Issue 3Page: 252KeywordsDrug therapyEdemaHematology and oncologyHemoglobinMedical risk factorsMicrocirculationPhlebotomyPolycythemia veraSerologyUlcers ePublished: 15 August 2000 Issue Published: 1 August 1998 Copyright & PermissionsCopyright © 1998 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Person-al Journeys: Reflections on Personhood and Dementia Based on Ethnographic Research and Family Experience
Authors: Catherine Myser
Journal: The American Journal of Bioethics (2007)

Click to increase image sizeClick to decrease image size Acknowledgement: This short piece is dedicated to my father as he was then (in the time of tall tales and hijinks); as he is now (in the time of fading photos); and as he will be in future, as long as we have the (sometimes extraordinarily challenging) pleasure of his company. Notes 1. My father's adult-onset hydrocephalus was originally due to an obstructed aqueduct of Sylvius diagnosed at age 39 to 40 years. The pressure in his ventricles risking injury to his brain was relieved by a cerebral spinal fluid shunt. Over the following 32 years, he has had five shunt revisions; the most recent surgery was performed in September 2006. 2. My ethnographic research involved one academic year in all regional neonatal, maternal-fetal, and genetics units in Sweden (funded by a Fulbright Scholarship); two months at the All India Institute of Medical Sciences (New Delhi, India; funded by a Georgetown University Dissertation Research Travel Grant); and 18 months in various academic medical centers in multiple regions of the United States. I conducted in-depth, structured, and open-ended interviews of 250 healthcare professionals; conducted participant observation in clinics and patient-care meetings; and triangulated resulting data with relevant bioethics, social science, health professional, governmental and policy publications to study and elaborate the ethical concepts of “personhood,” “quality of life,” and “best interests” as conceived and employed by health professionals and parents/family members in selective nontreatment and termination decisions, compared across differing sociocultural contexts. 3. This application of the concept of speciesism by health professionals is in direct opposition with that of animal rights philosopher Peter Singer, who overtly seeks to contest speciesism by arguing that healthy animals are more deserving of personhood status than severely handicapped human infants. Applications of speciesism may thus depend on one's preexisting or learned commitments and sensibilities. (Human) health professionals contrasted their own expertise and duties to care for humans with the expertise and duties of veterinarians to value and treat animals. 4. Similar factors may also operate in philosophers' and ethicists' theories of personhood that hyper-value rationality. 5. In all three countries studied, abortion laws also grounded such thinking, even in countries where legal definitions distinguishing persons, nonpersons and potential persons for legal purposes conflicted with clinical assessments. 6. See, as a powerful example, the data outlined in my chapter on India (CitationMyser 1994, 183–214).
Recurrent Ectopic Gestation on Same Side as Previous Salpingectomy
Authors: S. Gee
Journal: BMJ (1945)

MEDBRATSoURNAL841dysfunction, and recent infection.Pregnant and nursing mothers were also excluded.The apparatus used for the dark-adaptation test was that described by Yudkin (1941b), with the addition of a means of stabilizing the voltage.The procedure was as follows:Method.-Each subject was generally examined as indicated above, and the test explained and demonstrated.They were put into the dark-room at 10-minute intervals.Before entering the dark-room no subject had been in the hospital less than half an hour, to safe- guard against the effects of exposure to previous high brightnesses (Craik and Vernon, 1942).At the 'end of the first subject's 30 minutes' dark-adaptation time the test was made, and so on with the remainder at 10-minute intervals.By this arrangeme-nt the intervals between subjects entering the dark-room and being tested were balanced so that all were dark-adapted for 30 minutes.The test object (arrow) was first shown at a brightness which could be seen fairly easily, and the brightness decreased until the threshold reading was obtained.The test was then continued to 40 minutes.As under the conditions of the test the expected difference between the readings at 30 minutes' and 40 minutes' dark-adaptation time is not more than 0.1 pylll log unit, subjects showing greater amounts than this were re-tested.In addition all readings of 3.83 ,u,ul log units and over were confirmed.The threshold measurements of brightness seen at 30 minutes' dark-adaptation time expressed as log yybl were those taken.a
Do get in touch
Authors: Simon Hatcher, David Owens
Journal: BMJ (2005)

transportation and road safety agencies (including vehicle designers).One measure should include changing crash investigation processes to identify SUVs in vehicle-pedestrian impact statistics.Given the increasing economic importance of the SUV market to car manufacturers, traffic safety activists in the health professions will need to keep pressure on governments to make sure they don't put economic and industrial interests ahead of effective safety strategies. 10 In the meantime, informing consumers of the increased risk to pedestrians from SUVs may represent a useful first step in raising public awareness.The Irish Medical Organisation has recently called on motor manufacturers and distributors to display warning notices on SUVs that advise potential purchasers of the increased risk of severe injury and death to pedestrians associated with these vehicles.Resistance from the industry to such initiatives is likely to be strong, just as it has been from the tobacco industry for warnings on cigarettes. 11Nevertheless, healthcare advocates should take heart from previous successful traffic safety initiatives. 12Addressing the hazards posed by SUVs to pedestrians is an emerging and real traffic safety challenge in the developed world.
Trihalomethanes as initiators and promoters of carcinogenesis.
Authors: M A Pereira, L H Lin, J M Lippitt, S L Herren
Journal: Environmental Health Perspectives (1982)

Chloroform and other trihalomethanes are contaminants of drinking water that have been demonstrated to be carcinogenic in laboratory animals. Determination of the mechanism of carcinogenicity of chloroform is required so that the animal data can be extrapolated to estimate the human health hazard. The extent of the binding of chloroform to rat liver and kidney DNA was approximately 0.1% the level of binding found for dimethylnitrosamine. Neither chloroform nor bromoform, in contrast to diethylnitrosamine-initiated GGTase-positive foci in either intact or partial hepatectomized rats, promoted with phenobarbital. Tumor-promoting activity of chloroform was indicated by the slight significant increase, compared to untreated controls, in the incidence of GGTase-positive foci in rats initiated with diethylnitrosamine (DENA) followed by the administration of chloroform twice weekly for a total of 15 doses. In this study, rats administered only the DENA or the chloroform did not contain an increased incidence of GGTase-positive foci compared to untreated controls. However, the incidence of foci in the group that received DENA followed by chloroform was not statistically different from that in either the group that received only the DENA or only the chloroform. In conclusion, we were unable to demonstrate tumor-initiating activity for chloroform, and the tumor-promoting activity of chloroform indicated by our results requires further confirmation.
Abstract A56: H3K9me3-based ChIP-seq analysis unveils global reprogramming in Cyclin D1-driven cellular senescence
Authors: Mohammad Harajly, Noel Ghanem, Raya Saab
Journal: Cancer Research (2013)

Abstract Senescence is a permanent G1 cell-cycle arrest that can be triggered by acute stresses such as activated oncogenes and chemotherapeutic agents, and serves as a barrier to cancer development. Senescent cells exhibit distinct chromatin features compared with proliferating cells, known as senescence-associated heterochromatin foci (SAHF). These foci are enriched with histone H3 trimethylated at lysine 9 (H3K9me3), and are thought to impose a repressive state on regional genes. We performed genome-wide identification of elements associated with H3K9me3 by ChIP-seq technology, using an in vivo model of senescent pineal cells driven by Cyclin D1 oncogenic signaling, and compared them to non-senescent (Cyclin D1 expressing but p53-null) counterparts. We identified a set of genes whose H3K9me3 enrichment level was significantly changed (&amp;gt;2-fold). We also analyzed gene expression profiles on Affymetrix transcriptome chips. We found that about 50% of genes associated with H3K9me3 exhibited significant reduction in expression, while other genes were either upregulated or showed no change in expression. Gene ontology analysis clustered the genes into several functional groups, including cell-cycle control, transcription regulation, protein metabolism, cellular differentiation, and cellular adhesion. Notably, the gene ontology clustering showed that genes associated with H3K9me3 in senescent cells clustered into distinctly different functional programs than those associated with H3K9me3 in cells that had bypassed senescence. Our data indicate that chromatin changes in cellular senescence are informative regarding a distinct functional phenotype of the senescent condition. The mechanisms by which such changes contribute to tumor suppression are under active investigation. Citation Format: Mohammad Harajly, Noel Ghanem, Raya Saab. H3K9me3-based ChIP-seq analysis unveils global reprogramming in Cyclin D1-driven cellular senescence. [abstract]. In: Proceedings of the AACR Special Conference on Chromatin and Epigenetics in Cancer; Jun 19-22, 2013; Atlanta, GA. Philadelphia (PA): AACR; Cancer Res 2013;73(13 Suppl):Abstract nr A56.
Chemoattractants induce rapid release of the interleukin 1 type II decoy receptor in human polymorphonuclear cells.
Authors: F Colotta, S Orlando, E J Fadlon, S Sozzani, C Matteucci, A Mantovani
Journal: The Journal of Experimental Medicine (1995)

Molecules representative of different classes of chemotactic agents, including formyl-Met-Leu-Phe (FMLP), C5a, leukotriene B4, platelet-activating factor, and interleukin (IL)-8, caused a rapid reduction in the IL-1 binding capacity by human polymorphonuclear leukocytes (PMN), a cell type expressing predominantly the IL-1 type II decoy receptor (IL-1 decoy RII). N-t-Boc-Met-Leu-Phe, an antagonist for the FMLP receptor, inhibited the loss of IL-1 binding capacity induced by FMLP. Monocyte chemotactic protein 1, a chemokine related to IL-8 but inactive on PMN, had no effect on IL-1 binding in this cell type. FMLP was selected for further detailed analysis of chemoattractant-induced loss of IL-1 binding by PMN. The action of FMLP was rapid, reaching 50% of its maximum (80%) at 30 s, the earliest measurable time point, and plateauing between 10 and 30 min. Dose-response analysis revealed that maximal reduction of IL-1 binding was reached at FMLP concentrations that were also optimal for chemotaxis (50% effective dose = 5 x 10(-9) M). The loss of IL-1 binding capacity caused by FMLP was determined by a reduction in receptor number with no change in their affinity. The effect of FMLP on IL-1 receptor (IL-1R) was selective in that the PMN surface structures IL-8R, CD16, CD18, and major histocompatibility complex class I antigens were unaffected under these conditions. Loss of surface IL-1R was not due to an augumented rate of internalization. FMLP caused rapid release of a 45-kD IL-1-binding molecule identified as the IL-1 decoy RII. After FMLP-induced release, PMN reexpressed newly synthesized receptors, reaching basal levels by 4 h. FMLP-induced release of the IL-1 decoy RII did not impair the responsiveness of PMN to IL-1 in terms of promotion of survival and cytokine production. FMLP-induced release of the IL-1 decoy RII was unaffected by protein synthesis inhibitors, was blocked by certain protease inhibitors, and was mimicked by agents (the Ca++ ionophore A23187 and phorbol myristate acetate) that recapitulate elements in the signal transduction pathway of chemoattractant receptors. The time frame and concentration range of chemoattractant-induced rapid release of the IL-1 decoy RII are consistent with the view that IL-1 decoy RII release is an early event in the multistep process of leukocyte recruitment.(ABSTRACT TRUNCATED AT 400 WORDS)
Epoetin Dosing and Dialysis Facility Ownership
Authors: Deborah L. Regidor, Kamyar Kalantar-Zadeh, Csaba P. Kovesdy
Journal: JAMA (2007)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Violence in the Home: Interdisciplinary Perspectives
Authors: Carl C. Bell
Journal: JAMA (1987)

This is an informative book written by a multidisciplinary group of professionals who are experts in their fields on family violence. It was "designed primarily for mental health service providers who need to know about research findings on family violence as well as about exemplary clinical and community interventions." The book fulfills its function in an admirable manner. The first part of the book gives an overview of violence in American society. The chapter entitled "Violence in the Society" is superior, as it fairly covers cultural and subcultural issues related to violence (eg, the alleged Southern subculture of violence, the alleged subculture of poverty, and the masculine subculture). The media as a source of violence and social controls and procedures designed to reduce violence are also well discussed. Another well-done chapter illuminates the extent of family violence and lists five characteristics of families experiencing this scourge. Part 2 focuses on
Predicting hospital-associated mortality for Medicare patients. A method for patients with stroke, pneumonia, acute myocardial infarction, and congestive heart failure
Authors: J. Daley
Journal: JAMA (1988)

We created a microcomputer-based system that uses characteristics of the patient at admission to predict death within 30 days of hospital admission for Medicare patients with stroke, pneumonia, myocardial infarction, and congestive heart failure. These conditions account for 13% of discharges and 31% of 30-day mortality for Medicare patients over 64 years of age. The system was calibrated on a stratified, random sample of 5888 discharges (about 1470 for each condition) from seven states, with stratification by hospital type to make the sample nationally representative. The predictors must be specially abstracted from the medical record. The cross-validated R2 for predictions is 0.14 to 0.25, which is better than the values for other systems for which we have data. Risk-adjusted predicted group mortality rates may be useful in interpreting information on unadjusted mortality rates, and patient-specific predictions may be useful in identifying unexpected deaths for clinical review.
An elusive concept?
Authors: J. Ashton
Journal: BMJ (2000)

“Happiness is a warm gun” wrote John Lennon many years ago, and millions of us still wish he hadn't, for it may have been the seed that was planted in Mark Chapman's disturbed mind to surface sometime later as an assassin's hand on the trigger outside the Dakota buildings in New York.

Yet happiness is an elusive concept, rather like love. As a young psychiatric registrar struggling to make sense of extreme mental states including mania and acute schizophrenia, I suggested to my consultant that if we were to understand the processes involved in hypomanic states we might do well to study acute infatuation and romantic love. Not for the first time I was thought to be off the wall. Years later, however, a Scandinavian colleague lent validity to my musings when he claimed …
Evaluation of heart rate variability, late ventricular potentials, and inducibility of ventricular tachycardia in patients with myotonic dystrophy type 1
Authors: Antonio Dello Russo, Giuseppe De Martino, Sergio Valsecchi, Loredana Messano, Gemma Pelargonio, Tommaso Sanna, Daniele Gabrielli, Manuela Pace, Michela Casella, Tiziana Chiriaco, Gaetano Antonio Lanza, Paolo Zecchi, Fulvio Bellocci
Journal: Journal of the American College of Cardiology (2003)
Phylogenetic Relationships, Ecological Correlates, and Molecular Evolution Within the Cavioidea (Mammalia, Rodentia)
Authors: Diane L. Rowe, Rodney L. Honeycutt
Journal: Molecular Biology and Evolution (2002)

A molecular phylogeny of the rodent superfamily Cavioidea was derived using two nuclear sequences (exon #10 of the growth hormone receptor gene and intron #1 of the transthyretin gene) and one mitochondrial gene (12S rRNA). A combined analysis produced a highly derived and well-supported phylogenetic hypothesis that differed from traditional taxonomy primarily in the placement of two taxa. Kerodon, traditionally included within the subfamily Caviinae with guinea pigs and its relatives, is placed sister to the family Hydrochaeridae and closely aligned with the subfamily Dolichotinae. Inclusion of Hydrochaeris within the Caviidae renders the familial classification paraphyletic. Our data further support the taxonomic separation of the families Agoutidae and Dasyproctidae. Both the molecular and traditional morphological interpretations are assessed in testing an ecological constraints hypothesis regarding social behaviors. Whereas traditional taxonomy is consistent with an environmental constraints explanation for social behavior, the molecular data suggest that phylogenetic effects may be a more important factor in the evolution of social behavior in this group. Although lineage-specific rate heterogeneity was identified in all three molecular data sets, no significant support was obtained for the metabolic rate hypothesis. However, both nuclear genes displayed patterns in accordance with the generation time hypothesis.
Effect of the quaternary ammonium compound trospium chloride on 24 hour jejunal motility in healthy subjects.
Authors: T Schmidt, R Widmer, A Pfeiffer, H Kaess
Journal: Gut (1994)

This study aimed to record 24 hour jejunal motility in healthy ambulant subjects and to analyse changes in motility caused by the oral administration of an anticholinergic agent, the quaternary ammonium compound, trospium chloride. In a placebo-controlled, double blind crossover trial, 24 hour jejunal motility was recorded in 12 healthy volunteers, aged 25 (21-30) years, using a digital data logger connected to two strain-gauge transducers mounted 20 cm apart in a flexible nasojejunal catheter. A computer program was developed to determine contraction parameters. Trospium chloride (15 mg orally thrice daily) prolonged the duration of irregular contractile activity after meals (p &lt; 0.02) and reduced its contraction frequency and amplitude (p &lt; 0.001). In the fasting state, the cycle length of the migrating motor complex was prolonged (p &lt; 0.01) by an extended phase I (p &lt; 0.025). Phase III was shortened (p &lt; 0.005) and showed a slower aboral migration velocity (p &lt; 0.005). Clustered contractions were less frequent during postprandial and fasting periods (p &lt; 0.01). Runs of clustered contractions were completely absent with trospium chloride. Digital manometry was useful for long term recordings of jejunal motility and enabled the motor effects of an anticholinergic agent to be characterised in ambulant subjects.
Italian doctors face criminal allegations over bribes
Authors: Fabio Turone
Journal: BMJ (2004)

More than 4700 Italian doctors, managers, and employees of the British pharmaceutical giant GlaxoSmithKline (GSK) are to face allegations of crimes ranging from giving and receiving illicit compensation for prescribing or recommending a specific drug through to corruption and criminal association.

These allegations are the result of a two year investigation by the tax police in Verona ( BMJ 2003;326: 413). GSK itself is accused of fiscal fraud and corporate crime.

The inquiry involved all 94 Italian provinces and brought to light a complex monitoring system that …