ACHLORHYDRIA AND PEPTIC ULCER: A FURTHER STUDY OF THE RÔLE OF PEPTIC ACTIVITY IN THE PATHOGENESIS AND COURSE OF PEPTIC ULCER
Authors: W E RICKETTS, W L PALMER
Journal: Annals of Internal Medicine (1949)

Article1 January 1949ACHLORHYDRIA AND PEPTIC ULCER: A FURTHER STUDY OF THE RÔLE OF PEPTIC ACTIVITY IN THE PATHOGENESIS AND COURSE OF PEPTIC ULCERWILLIAM E. RICKETTS, WALTER LINCOLN PALMER, F.A.C.P., JOSEPH B. KIRSNER, F.A.C.P., ANNA HAMANNWILLIAM E. RICKETTSSearch for more papers by this author, WALTER LINCOLN PALMER, F.A.C.P.Search for more papers by this author, JOSEPH B. KIRSNER, F.A.C.P.Search for more papers by this author, ANNA HAMANNSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-30-1-24 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptINTRODUCTIONIn 1910 Schwartz1 enunciated the dictum "no acid—no ulcer" the validity of which has been challenged repeatedly throughout the years. The purpose of this paper is to present a further study on the occurrence of ulcer in acid and non-acid stomachs and, more particularly, on the effect of achlorhydria upon the course of peptic ulcer.Previous studies2, 3, 4have tended to establish the invariable presence of acid gastric juice in patients with chronic peptic ulcer and the absence of ulcer in patients with persistent achlorhydria as in pernicious anemia.5, 6Washburn and Rozendaal7did not find a single...Bibliography1. SCHWARTZ K: Über penetrierende Magen- und Jejunalgeschwure, Beitr. klin. Chir., 1910, lxvii, 96. Google Scholar2. PALMER WL: The mechanism of pain in gastric and duodenal ulcers I, Achlorhydria, 1926, xxxviii, 603-611. Google Scholar3. PALMER WL: The rôle of acid gastric juice in gastric and duodenal ulceration, Trans. Coll. Phys. Philadelphia, 1942, ix, 191-200. Google Scholar4. PALMERNUTTER WLPB: Peptic ulcer and achlorhydria. A further study of the role of acid gastric juice in the pathogenesis of peptic ulcer, Arch. Int. Med., 1940, lxv, 499-509. CrossrefGoogle Scholar5. STURGIS CC: Present status of pernicious anemia; experience with 600 cases over 8 years, Ann. Int. Med., 1936, x, 283-289. Google Scholar6. GOLDHAMER SM: The gastric juice in patients with pernicious anemia in induced remission, Am. Jr. Med. Sci., 1937, cxciii, 23-28. CrossrefGoogle Scholar7. WASHBURNROZENDAAL RNHM: Gastric lesions associated with pernicious anemia, Ann. Int. Med., 1938, xi, 2172. Google Scholar8. KAHN JR: Absence of peptic ulcer in pernicious anemia, Am. Jr. Med. Sci., 1937, cxciv, 463. CrossrefGoogle Scholar9. MURPHYHOWARD WPI: Analysis of complications occurring in series of patients with pernicious anemia, Rev. Gastroenterol., 1936, iii, 98-110. Google Scholar10. 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Google Scholar15. WINKELSTEIN A: The significance of the gastric acidity in the surgical treatment of peptic ulcer, Surg. Clin. North Am., 1947, xxvii, 255-260. CrossrefGoogle Scholar16. RICKETTSPALMERHAMANN WEWLA: Radiation therapy in peptic ulcer. To be published. Google Scholar17. PALMERTEMPLETON WLFE: Effect of radiation therapy in gastric secretion, Jr. Am. Med. Assoc., 1939, cxii, 1429-1434. CrossrefGoogle Scholar18. RICKETTSKIRSNERHUMPHREYSPALMER WEJBEMWL: Effects of radiation therapy on the gastric mucosa. To be published. Google Scholar19. HOLLANDER F: What is pH? Explanation of various measures of acidity employed in gastroenterology, Gastroenterology, 1945, iv, 497-508. Google Scholar20. HUNTER J: On digestion of the stomach after death, Philos. Trans. Roy. Soc., London, 1772, lxii, 447. Google Scholar21. WHITLOW JE: The protective action of mucus, Master's Thesis Loyola University. (Unpublished.) Google Scholar22. WOLFWOLFF SHG: Studies on mucus in the human stomach, Gastroenterology, 1948, x, 251-255. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Chicago, Illinois*Presented in part before the Association of American Physicians, Atlantic City, N. J., May, 1948. Received for publication June 26, 1948.From the Frank Billings Medical Clinic, Department of Medicine, University of Chicago. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byHeuristic Reevaluation of the Bacterial Hypothesis of Peptic Ulcer Disease in the 1950sPostbulbar duodenal ulcer in a patient with pentagastrin-fast achlorhydriaPeptisches UlcusAn Apparent Exception to Schwarz’s Dictum, “No Acid — No Ulcer”Gastric Irradiation in the Treatment of Peptic UlcerHeidelberg Capsule IGastric AnalysisTHE EFFECT OF X-RAY THERAPY ON GASTRIC ACIDITY AND ON 17-HYDROXYCORTICOID AND UROPEPSIN EXCRETION*J. A. RIDER, M.D., H. C. MOELLER, M.D., T. L. ALTHAUSEN, M.D., F.A.C.P., G. E. SHELINE, M.D.The Early Gastric Response to Irradiation, a Serial Biopsy StudyThe problem of peptic ulcerEffect of a lysozyme inactivating anion exchange polymer in treatment of peptic ulcer: Experimental and clinical studyJejunal Ulcer in the Presence of Gastric Achylia–A Case ReportTHE TREATMENT OF INTRACTABLE PEPTIC ULCER*WALTER L. PALMER, M.D., F.A.C.P., JOSEPH B. KIRSNER, M.D., F.A.C.P., IRWIN LEVIN, M.D.Aluminum hydroxide and magnesium trisilicate plus mucin in the treatment of 125 patients with peptic ulcerPerforation of a Gastric Ulcer Following Intensive Radiation TherapyBenign Gastric Ulcers Occurring in the Presence of Achlorhydria 1 January 1949Volume 30, Issue 1Page: 24-39KeywordsAchlorhydriaGastric ulcersPathogenesisPeptic ulcersStomachUlcers Issue Published: 1 January 1949 PDF downloadLoading ...