PHARMACODYNAMICS OF PULMONARY ABSORPTION IN MAN. II. THE INFLUENCE OF VARIOUS DILUENTS ON AEROSOL AND INTRATRACHEAL PENICILLIN
Authors: J F BEAKEY, E A GAENSLEY, M S SEGAL
Journal: Annals of Internal Medicine (1949)

Article1 November 1949PHARMACODYNAMICS OF PULMONARY ABSORPTION IN MAN. II. THE INFLUENCE OF VARIOUS DILUENTS ON AEROSOL AND INTRATRACHEAL PENICILLINJOHN F. BEAKEY, EDWARD A. GAENSLER, MAURICE S. SEGAL, F.A.C.P.JOHN F. BEAKEY, EDWARD A. GAENSLER, MAURICE S. SEGAL, F.A.C.P.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-31-5-805 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe pharmacodynamics of pulmonary absorption has not been generally considered in the clinical reports on the success of aerosol and intratracheal therapy. There is equally meager information regarding the action of various pharmacologically active diluents in promoting or retarding absorption of penicillin from the pulmonary epithelium.In a recent study1we described various factors influencing absorption from the normal human lung. Crystalline penicillin G potassium (100,000 units) in physiologic saline was administered intramuscularly, intratracheally and by oxygen-aerosolization. The blood levels and urinary excretion, following intratracheal injection, were lower but more sustained than those following intramuscular administration. Rapid absorption would normally...Bibliography1. GAENSLERBEAKEYSEGAL EAJFMS: Pharmacodynamics of pulmonary absorption in man. I. Aerosol and intratracheal penicillin, Ann. Int. Med., 1949, xxxi, 582. Google Scholar2. GRAESERROWE JBAH: Inhalation of epinephrine for the relief of asthmatic symptoms, Jr. Allergy, 1935, vi, 415. CrossrefGoogle Scholar3. SEGALBEAKEY MSJF: The use of 1-(3′-4′,-dihydroxyphenyl)-2-isopropylaminoethanol for the management of bronchial asthma. A preliminary report, Bull. New England Med. Center, 1947, ix, 62. Google Scholar4. RAMMELKAMP CH: A method of determining the concentration of penicillin in body fluids and exudates, Proc. Soc. Exper. 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SEGAL, F.A.C.P.Affiliations: Boston, Massachusetts*Received for publication September 11, 1948.From the Department of Inhalational Therapy, Boston City Hospital and the Department of Medicine, Tufts College Medical School.This study was aided by a grant from the Commercial Solvents Corporation. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byAlternative Methods of Drug AdministrationDifferences in plasma lidocaine levels with endotracheal drug therapy secondary to total volume of diluent administeredThe effect of dilution on plasma lidocaine levels with endotracheal administrationThe use of endotracheal medication in cardiac emergenciesEndotracheal drug therapyBlood levels of diazepam after endotracheal administration in dogsAuthor's replyLOCALIZED PULMONARY DISEASESBibliographyAsthma bronchiale 1 November 1949Volume 31, Issue 5Page: 805-820KeywordsBloodEpitheliumExcretionHospital medicineLungsPenicillinPharmacodynamicsPotassium ePublished: 1 December 2008 Issue Published: 1 November 1949 PDF downloadLoading ...