AGRANULOCYTOSIS DUE TO PHENYLBUTAZONE
Authors: R E GEESAMAN, F L JAMES
Journal: Annals of Internal Medicine (1957)

Case Reports1 January 1957AGRANULOCYTOSIS DUE TO PHENYLBUTAZONEFREBURN L. JAMES, A.B., M.D., RICHARD E. GEESAMAN, M.D.FREBURN L. JAMES, A.B., M.D.Search for more papers by this author, RICHARD E. GEESAMAN, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-46-1-152 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptIt is well known that phenylbutazone is a hazardous medication, although it has been very effective therapeutically in relief of pain of arthritis and similar conditions. Bruck et al.1 studied the toxicity of phenylbutazone and reported the following as being the usual toxic effects: epigastric pain and burning, dry mouth, buccal irritation, edema, urticaria, diarrhea, headache, purpura, and precipitation of oliguria and renal failure. Their series did not include agranulocytosis or neutropenia, but this is a recognized danger.Beutler and Bergenstal2reported a case of perforated duodenal ulcer with neutropenia. The bone marrow in this case showed maturation arrest at...Bibliography1. BruckFearnleyMeanockPatley EMEIH: Phenylbutazone therapy; relation between the toxic and therapeutic effects and the blood level, Lancet 1: 225-228 (Jan. 30) 1954. CrossrefGoogle Scholar2. BeutlerBergenstal EDM: Perforated duodenal ulcer with neutropenia and death in a patient receiving phenylbutazone therapy, Gastroenterology 25: 72-74, 1953. CrossrefMedlineGoogle Scholar3. SteelMoffatt SJJL: Stevens-Johnson syndrome and granulocytopenia after phenylbutazone, Brit. M. J. 1: 795 (Apr. 3) 1954. CrossrefMedlineGoogle Scholar4. O'BrienStorey DJG: Death from hypersensitivity due to phenylbutazone, Brit. M. J. 1: 792-794 (Apr. 3) 1954. CrossrefMedlineGoogle Scholar5. ConeHanniganTeicher RBCAR: Erythema multiforme bullosum following phenylbutazone treatment for arthritis. Report of fatal case, Arch. Dermat. and Syph. 69: 674-677 (June) 1954. CrossrefGoogle Scholar6. NassimPilkington JRT: Multiple visceral lesions due to phenylbutazone toxicity, Brit. M. J. 2: 1028-1029 (Oct. 30) 1954. CrossrefMedlineGoogle Scholar7. Wood IH: Fatal case of agranulocytosis following phenylbutazone, Brit. M. J. 1: 802 (Apr. 3) 1954. CrossrefMedlineGoogle Scholar8. EnglemanKruppRinehartJonesGibson EPMAJFRCJR: Hepatitis following the ingestion of phenylbutazone, J. A. M. A. 156: 98-101 (Sept. 11) 1954. CrossrefMedlineGoogle Scholar9. Jespersen K: Butazolidin, Ugesk. f. læger 116: 846-848 (June) 1954. MedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Boulder, Colorado*Received for publication May 23, 1955.From the Boulder Colorado Sanitarium and Hospital and the Department of Internal Medicine, Boulder Medical Center, Boulder, Colorado.Requests for reprints should be addressed to Freburn L. James, M.D., Pathologist, Port Huron Hospital, Port Huron, Michigan. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byNon-steroidal anti-inflammatory drugs (NSAIDs)RHEUMATISM AND ARTHRITIS: REVIEW OF AMERICAN AND ENGLISH LITERATURE OF RECENT YEARS (THIRTEENTH RHEUMATISM REVIEW)*CHARLEY J. SMYTH, M.D., F.A.C.P., ROGER L. BLACK, M.D., FELIX E. DEMARTINI, M.D., IVAN F. DUFF, M.D., F.A.C.P., EPHRAIM P. ENGLEMAN, M.D., F.A.C.P., DONALD C. GRAHAM, M.D., F.R.C.P.(C), MAX M. MONTGOMERY, M.D., F.A.C.P., HOWARD F. POLLEY, M.D., F.A.C.P., EDWARD F. ROSENBERG, M.D., F.A.C.P., CARLOS F. SACASA, M.D., F.A.C.P., OTTO STEINBROCKER, M.D., HANS WAINE, M.D., GEORGE M. WILSON JR., M.D. 1 January 1957Volume 46, Issue 1Page: 152-155KeywordsDiarrheaEdemaHospital medicineNeutropeniaPainPharyngitisRashesRenal failureToxicityUrticaria Issue Published: 1 January 1957 PDF downloadLoading ...