tbuckley/cabot-search huggingface dataset:
Prevention of Contrast-Induced Nephropathy With Sodium Bicarbonate
Authors: L Shavit, M Lifschitz, J Plaksin, I N Slotki
Journal: JAMA (2004)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Dermatotmal chronic cutaneous graft-versus-host disease at the site of prior herpes zoster
Authors: None Lacour, None Sirvent, None Monpoux, None Perrin, None Castanet, None Michel, None Boutte
Journal: British Journal of Dermatology (1999)

Journal Article Dermatotmal chronic cutaneous graft‐versus‐host disease at the site of prior herpes zoster Get access J-P. Lacour, J-P. Lacour Departments of Dermatology Search for other works by this author on: Oxford Academic Google Scholar N. Sirvent, N. Sirvent Paediatrics, Hôpital Archet‐2, BP 3079, 06202 Nice cedex 3, France Search for other works by this author on: Oxford Academic Google Scholar F. Monpoux, F. Monpoux Paediatrics, Hôpital Archet‐2, BP 3079, 06202 Nice cedex 3, France Search for other works by this author on: Oxford Academic Google Scholar C. Perrin, C. Perrin Department of Pathology, Hôpital Pasteur, Nice, France Search for other works by this author on: Oxford Academic Google Scholar J. Castanet, J. Castanet Departments of Dermatology Search for other works by this author on: Oxford Academic Google Scholar G. Michel, G. Michel Department of Paediatric Haematology, Hôpital La Timone, Marseille, France E mail: lacour@unice.fr Search for other works by this author on: Oxford Academic Google Scholar P. Boutte P. Boutte Paediatrics, Hôpital Archet‐2, BP 3079, 06202 Nice cedex 3, France Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 141, Issue 3, 1 September 1999, Pages 587–589, https://doi.org/10.1046/j.1365-2133.1999.03074.x Published: 01 September 1999
The Computer-Based Patient Record: An Essential Technology for Health Care
Authors: Elaine B. Steen, Don E. Detmer
Journal: Annals of Internal Medicine (1992)

From the Publisher:
In its first edition, this volume presented a blueprint for introducing the computer-based patient record (CPR) nationwide within the next decade. An expert committee explored the potential of machine-readable CPRs to improve diagnostic and care decisions, provide a database for policy-making, and much more. This revised edition adds new information to the original book. One commentary describes recent developments in the United States, including the creation of a computer-based patient record institute - a strategy recommended in the original volume to promote and facilitate implementation of the CPR. The second commentary highlights developments in Europe. The volume also explores such issues as privacy and confidentiality, costs, the need for training, legal barriers to CPRs, and other key topics.
Abstract P207: Sociodemographic Predictors of Overweight or Obese Incidence Among Normal Weight 18-Year Olds
Authors: Deborah R Young, Corinna Koebnick, Jin-Win Hsu
Journal: Circulation (2014)

The transition from adolescence to adulthood is associated with increased risk for excess weight gain. Transitioning adults are relatively difficult to study, however, because unless they matriculate to secondary education there are few opportunities to track them. Thus, demographic and socioeconomic factors associated with overweight obesity are not well-documented, much less so among adolescents who have maintained normal weight throughout adolescence. We examined the incidence of overweight and obesity among 10,723 healthy, normal weight (body mass index [BMI] &lt; 25 kg/m 2 )18-year olds in 2008 who remained members of Kaiser Permanente Southern California through 2012. Sex, race/ethnicity, height, and weight were recorded in electronic medical records; BMI was calculated. Neighborhood education was determined from US 2000 Census block group data, and quartiles defined by the proportion of adults with an education below high school. We followed 3,677 men (BMI: 21.5±1.96) and 7,046 women (BMI: 21.2±2.0). Relative risks (RR) and 95% confidence intervals (CI) were determined controlling for sex, race/ethnicity, neighborhood education, and smoking history. During 34,660 person-years of follow-up (mean 3.23±1.34 years), we documented 2,672 incident cases of overweight (24.9%) and 237 of obesity (2.2%). The RR of overweight was 1.25 (95% CI: 1.13, 1.38) in the lowest quartile of neighborhood education compared with the highest quartile (test for trend p=0.001). The RR for obesity was 1.50 (95% CI: 1.00, 2.25; test for trend p=0.025). While women were less likely to become overweight than men (RR 0.88, 95% CI: 0.82, 0.94), they were twice as likely to become obese (RR: 1.99, 95% CI: 1.45, 2.72). Hispanics had greater risk of overweight (RR: 1.09, 95% CI: 1.00, 1.18) and Blacks had greater risk of obesity (RR: 1.46, 95% CI: 1.00, 2.15) than non-Hispanic whites. Compared with their non-Hispanic white peers, Asians had lower risk of overweight and obesity (RR: 0.79, 95% CI: 0.67, 0.93 and RR: 0.46, 95% CI: 0.21, 0.99, respectively). In conclusion, normal weight adolescents are at risk for becoming overweight as they transition to adulthood. Sociodemographic factors predict incidence of overweight and obesity. Women and Blacks are at particular risk for excessive weight gain trajectories.
Abstract 13030: Post-systolic Shortening and Early Systolic Lengthening in the Ischemic Segment are Affected by the Contractility in its Adjacent Segment
Authors: Daisuke Sakurai, Toshihiko Asanuma, Kasumi Masuda, Masamichi Oka, Koichiro Kotani, Katsuji Inoue, Satoshi Nakatani
Journal: Circulation (2014)

Background: Post-systolic shortening (PSS) and early systolic lengthening (ESL) are sensitive markers of acute myocardial ischemia and the magnitude of these deformation is considered proportional to the severity of ischemia. Theoretical and mathematical models have suggested these deformation is caused by the difference of contractility between the ischemic and its adjacent normal segments. However, it has not been fully confirmed in an in vivo model yet. The aim of the study was to investigate whether PSS and ESL are affected by the contractility of its adjacent segment in an animal model which underwent left anterior descending coronary artery (LAD) occlusion (ischemic segment) followed by left circumflex coronary artery (LCx) occlusion (adjacent segment). Methods: In 6 open-chest dogs, left ventricular short-axis images with frame rate of over 90 fps (GE Vivid E9) and hemodynamics data were acquired at 3 conditions: (1) at baseline, (2) during LAD occlusion, and (3) during both LAD and LCx occlusion. Circumferential strain was analyzed in the LAD and LCx segments by speckle tracking software. End-systolic strain (ε ES ) and the amplitude of PSS and ESL (ε PSS and ε ESL ) were measured. Results: During LAD occlusion, ε PSS and ε ESL in the LAD segment significantly increased compared with baseline (ε PSS , 1.2 ± 1.1% vs. 9.5 ± 2.7%, p&lt;0.05; ε ESL , 1.3 ± 1.0% vs. 8.5 ± 4.2%, p&lt;0.05). During both LAD and LCx occlusion, ε ES in the LCx segment decreased, and both ε PSS and ε ESL in the LAD segment significantly decreased compared with during LAD occlusion (ε PSS , 9.5 ± 2.7% vs. 2.8 ± 1.3%, p&lt;0.05; ε ESL , 8.5 ± 4.2% vs. 2.3 ± 1.9%, p&lt;0.05) (figure). Conclusions: PSS and ESL diminished with the decrease of contractility in its adjacent segment. This suggests PSS and ESL occur based on the interplay of contraction between ischemic and adjacent segments and do not always reflect the severity of ischemia.
Abstract 16993: An Antisense Inhibitor of Apolipoprotein C-III Significantly Decreases Nonesterified Fatty Acid Levels in Severe Hypertriglyceridemic Patients
Authors: Veronica Alexander, Diane Brisson, JoAnn Flaim, Steve Hughes, Walter Singleton, Richard Geary, Daniel Gaudet
Journal: Circulation (2014)

Background: Apolipoprotein C-III (apoC-III), a CV risk factor, plays a pivotal role in regulating plasma triglyceride (TG) levels. Elevated TG and its nonesterified fatty acid (NEFA) derivatives are associated with insulin resistance and type 2 diabetes. ISIS-APOCIII Rx selectively inhibits apoC-III protein synthesis in the liver and studies show it may improve insulin sensitivity in patients with type 2 diabetes. Treatment with ISIS-APOCIII Rx results in significant dose-dependent decreases in apoC-III and TG levels (Table) in patients with severe hypertriglyceridemia (SHTG) as monotherapy or add on to a stable dose of fibrate. The present study assessed the potential resulting change in NEFA levels in these patients. Methods: Adult patients with SHTG treated or untreated with fibrate were enrolled in a double-blind Phase 2 study to receive ISIS-APOCIII Rx (up to 300 mg) or placebo as weekly SC injections for 13 weeks. Baseline and end-of-treatment fasting serum samples were analyzed for NEFA levels. Results: Results show significant reductions in NEFA levels in line with reductions in TG levels at the 300 mg/week dose (the Phase 3 dose) of ISIS-APOCIII Rx (Table). ISIS-APOCIII Rx was generally safe and well tolerated. There were no clinically meaningful changes in liver tests or other laboratory values. Conclusions: Treatment with ISIS-APOCIII Rx reduces NEFA levels together with decreases in TG in patients with treated or untreated SHTG suggesting the potential for improvement in peripheral insulin sensitivity in these patients.
565. Modulation of the Acute Phase Response by Recombinant Adeno-Associated Viral Expression of the IL-1 Type 1 Soluble Receptor
Authors: Gregory G. Simon, Barry J. Byrne, Mark A. Atkinson
Journal: Molecular Therapy (2004)

Acute rejection is a leading cause of graft loss in transplant recipients. Studies on the pathogenesis of acute rejection have suggested a major contributory role for certain cytokines and acute phase proteins. Interleukin (IL)-1 is a potent proinflammatory cytokine that plays a critical role in initiating and maintaining immunogenic inflammation associated with acute rejection. Previous experiments have shown that IL-1 antagonists can help reduce acute inflammation associated with allograft rejection. We performed a series of experiments to determine whether administration of a recombinant adeno-associated viral (rAAV) vector expressing the soluble extracellular domains of type I receptor for IL-1B can reduce inflammation in a turpentine induced murine inflammation model. METHODS: Experimental wt B6/129 mice were injected intramuscular using 2109 IU with either rAAV2-CMV-sIL-1r or rAAV2-CMV-LacZ. Saline injected B6/129 mice served as negative controls and B6/129 IL-1 receptor KO mice served as the positive control for these experiments. Four weeks after rAAV injection, both experimental and control mice underwent induction of inflammation by subcutaneous administration of 100 microliters sterile turpentine. Mice were followed for 6 days following turpentine injection. Blood samples were taken at 12 hours, three days, and six days pre- and post-turpentine administration. Sera samples were used to measure cytokine and acute phase protein levels. Body weight and food intake were measured daily during the course of the study. RESULTS: Following subcutaneous injection into the left hindlimb with sterile turpentine, the mice previously injected with saline or control rAAV2-CMV-LacZ began to lose weight, while those injected previously with rAAV2-CMV-sIL-1r did not experience as significant (P < 0.12) a loss in weight and the IL-1r KO mice gained weight. The amount of food intake showed a reduction in the mice that were administered saline, LacZ virus, and the IL-1r KO mice over those that were injected with rAAV2-CMV-sIL-1r. Serum levels of proinflammatory cytokines and acute phase proteins such as IL-6, Serum Amyloid A, and Serum Amyloid P showed a significant increase (P < 0.05) in the saline and LacZ injected mice over the KO and experimental mice. CONCLUSIONS: Based on the experimental results, mice that were administered rAAV expressing soluble IL-1 receptor were able to withstand the inflammatory reaction from subcutaneous turpentine injection better than the saline and LacZ controls. The reduced proinflammatory cytokine and acute phase proteins correlated to a reduced weight loss and higher food intake verses the control animals. This data suggests that IL-1 antagonists such as soluble receptors for IL-1 may be used to attenuate the inflammation associated with acute allograft rejection. Future studies will evaluate the ability of rAAV2-sIL-1r to attenuate inflammation associated with acute graft rejection.
Cryoablation for Small Renal Masses: Selection Criteria, Complications, and Functional and Oncologic Results
Authors: Homayoun Zargar, Thomas D. Atwell, Jeffrey A. Cadeddu, Jean J. de la Rosette, Gunther Janetschek, Jihad H. Kaouk, Surena F. Matin, Thomas J. Polascik, Kamran Zargar-Shoshtari, R. Houston Thompson
Journal: European Urology (2015)
Abstract MP54: The Health Burdens Attributable to Suboptimal Diet in the US - a National Comparative Risk Assessment
Authors: Renata Micha, Gitanjali M Singh, Shahab Khatibzadeh, Peilin Shi, Saman Fahimi, Rebecca E Engell, Ali Mokdad, Chris J Murray, John Powles, Majid Ezzati, Dariush Mozaffarian
Journal: Circulation (2014)

Background: Suboptimal diet has become the leading cause of death and disability globally and in the US. Yet, the specific contributions of different dietary factors to poor health in the US are not established. Objective: To estimate the burdens of 12 key dietary factors on major chronic diseases in the US, overall and by age, sex, and disease. Methods: We used a comparative risk assessment framework to develop consistent and comparable methods to identify specific dietary factors with evidence for etiologic effects on coronary heart disease (CHD), stroke, diabetes, and cancers; estimate current national intake levels and their uncertainty, by age and sex; quantify etiologic effects of each diet-disease relationship, by age; and characterize optimal consumption levels of each dietary factor. We combined these inputs with national disease-specific deaths and disability-adjusted life-years (DALYs) to estimate burdens attributable to each dietary factor overall, and by age, sex, and disease. We quantified uncertainty using probabilistic simulation analyses for all our estimates. Results: In 2010, the 5 leading dietary causes of chronic disease mortality and morbidity in the US were low fruits, low nuts/seeds, high sodium, low vegetables, and high processed meats ( Figure ). Most dietary factors contributed to CHD burden. Leading causes of cancer mortality were low fruits, high processed meats, low milk, low vegetables, and high red meats. Leading causes of diabetes morbidity were high sugar-sweetened beverages, high processed meats, low whole grains, and high red meats. Conclusions: Our findings revealed a major impact of specific dietary factors on poor health in the US. Our study calls for policies and coordinated, multi-stakeholder efforts to improve diet in the US.
Abstract 17098: Comparison of Angiographic and 1-year Clinical Outcomes between Long Single Stent and Overlapping Double Stent in Patients with Newer Generation Drug-Eluting Stents for Similar Long Lesions
Authors: Naoki Mori, Masami Nishino, Naotaka Okamoto, Akihiro Tanaka, Takahiro Yoshimura, Nobuhiko Makino, Yasuyuki Egami, Ryu Shutta, Jun Tanouchi
Journal: Circulation (2014)

Background: Although overlapping coronary stents in long lesions by percutaneous coronary intervention are common, some clinical studies revealed adverse clinical and angiographic outcomes of early generation overlapping drug-eluting stents (DES) due to increased drug and polymer toxicity, as compared to non-overlapping or single DES. However, recent clinical reports have shown safety and efficacy outcomes of overlapping newer generation DES, as compared with early generation overlapping DES and newer generation non-overlapping DES. Thus, the purpose of this study was to compare angiographic and 1-year clinical outcomes between long single stent and overlapping double stent in patients treated with newer generation DES for similar long lesions. Methods: We analyzed 8-10 months angiographic and 1-year clinical outcomes of 106 patients treated with everolimus-eluting stent (EES, newer generation DES) in a de novo similar long lesions (≥ 32mm, ≤38mm) by a long single stent or overlapping double stents. We divided our patients into single long stent group and overlapping double stent group. We compared the incidence of in-stent restenosis (ISR), which was defined as more than 50% angiographical stenosis, and analyzed freedom from major adverse cardiovascular events (MACE: defined as the composite of death, myocardial infarction, or target vessel revascularization) and freedom from target lesion revascularization (TLR) at 1 year using Kaplan-Meier method. Results: The incidence of ISR at 8-10 months after stent implantation was similar between long single stent group (n=41) and overlapping double stent group (n= 65). The rate of freedom from MACE and TLR during 1-year were also similar between two groups (figures). Conclusions: According to our study, newer generation DES, EES, provided similar angiographic and 1-year clinical outcomes irrespective of overlap status in long lesions.
Abstract 5736: Diagnosis of Chronic Myocardial Ischemia by Speckle Tacking Echocardiography -A Comparative Animal Study-
Authors: Koichi Kimura, Katsu Takenaka, Kansei Uno, Aya Ebihara, Katsuhito Fujiu, Hiroshi Iwata, Masataka Sata, Ryozo Nagai
Journal: Circulation (2008)

A number of systolic and diastolic indexes for ischemic damage can be measured by 2D speckle tracking echocardiography (STE) including radial strain and strain rate as well as circumferential strain and strain rate on LV short-axis view. In addition, they could be derived from the subendocardium, subepicardium, mid-layer or total layer of the LV wall with new tracking software. The aim of our study is to compare the diagnostic abilities of these indexes in animal experiments. An Ameroid constrictor was placed around the left circumflex coronary artery in 19 pigs. Before and 4 weeks after the surgery, LV short-axis images were obtained at rest by transthoracic 2D echocardiography. Three pigs that had died after the surgery and 2 that had focal infarction in pathological studies were excluded from the study. Thus, in 14 pigs with 99% stenosis on coronary angiograms, we measured peak strain, peak S′, peak E′, time from QRS to peak strain, time from QRS to E′, and incidence of post-systolic shortening (PSS) in the endocardium, midcardium, and epicardium of the LV posterior wall using a new prototype speckle tracking software. None of the time indexes and PSS showed statistically significant results. ROC curve analysis (Table ) revealed that endocardial circumferential strain is the most diagnostic index of ischemia, which showed 79% sensitivity and 93% specificity. Endocardial circumferential strain measured by STE on LV short-axis view was the most useful index for detecting chronic severe myocardial ischemia. Table. Results of measurement in chronic ischemia(mean±SD)
Association of Nipple Piercing With Abnormal Milk Production and Breastfeeding
Authors: Catherine P Garbin, Jane P Deacon, Marnie K Rowan, Peter E Hartmann, Donna T Geddes
Journal: JAMA (2009)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal