tbuckley/cabot-search huggingface dataset:
Abstract 18400: Distinct Endothelial Function in Patients With Chronic Total Occlusion With Preserved Myocardial Viability
Authors: Yuichiro Arima, Seiji Hokimoto, Shinji Tayama, Satomi Iwashita, Tomonori Akasaka, Noriaki Tabata, Kenji Sakamoto, Kenichi Tsujita, Eiichiro Yamamoto, Tomoko Tanaka, Sunao Kojima, Koichi Kaikita, Hisao Ogawa
Journal: Circulation (2014)

Backgrounds: Coronary collateral vessels work as a detour and ameliorate ischemic myocardial damage. Induction or enhancement of the collateral growth is a novel therapeutic strategy for the ischemic heart disease, however their mechanisms are almost unknown. Patients with chronic total occlusion (CTO) who keep the intact myocardium maintain rich collateral sources, which perfuse the area of the occluded artery. We tried to assess the characteristics of patients with CTO compared with non-occlusive patients with ischemic heart disease and those with old myocardial infarction (OMI). Methods: Consecutive 264 patients from January 2010 to February 2014 were enrolled this study. First we assessed the myocardial viability using summed rest score (SRS) of thallium perfusion scintigraphy and divided into OMI patients (SRS greater than or equal to 4, OMI group, n=99) and the others with almost normal myocardial viabilities (n=165). Next we divided into CTO group (n=51) and Stenosis group (n=114) from the coronary angiographic findings. We also measured their peripheral endothelial function by reactive hyperemia peripheral arterial tonometry index (RHI). Results: There were no significant differences between CTO group and Stenosis group in clinical characteristics. Ln-RHI was lowest in the OMI group (OMI 0.53±0.21), furthermore, CTO group showed higher endothelial function than Stenosis group (CTO 0.71±0.21 vs Stenosis 0.63±0.23, p&lt;0.05). Multivariate logistic regression analysis identified high Ln-RHI as an independent factor associated with the presence of CTO (OR 2.523, 95% CI 1.119-5.687, p&lt;0.05) among preserved myocardial patients. Other factors did not show the statistical significance. Conclusion: Patient with CTO showed paradoxically high Ln-RHI values in spite of the existence of the total occlusion vessel. Enhanced endothelial function might promote the collateral vessel growth and protect myocardium from the irreversible damage.
Prognosis and response to therapy of first inpatient and outpatient heart failure event in a heart failure clinical trial: <scp>MADIT‐CRT</scp>
Authors: Hicham Skali, Edward M. Dwyer, Robert Goldstein, Mark Haigney, Ronald Krone, Marrick Kukin, Edgar Lichstein, Scott McNitt, Arthur J. Moss, Marc A. Pfeffer, Scott D. Solomon
Journal: European Journal of Heart Failure (2014)
Perinatally Administered Bisphenol A as a Potential Mammary Gland Carcinogen in Rats
Authors: Nicole Acevedo, Barbara Davis, Cheryl M. Schaeberle, Carlos Sonnenschein, Ana M. Soto
Journal: Environmental Health Perspectives (2013)

Background: Environmental exposure to bisphenol A (BPA) affects mammary gland development in rodents and primates. Prenatal exposure to environmentally relevant doses of BPA increased the number of intraductal hyperplasias and ductal carcinomas in situ by 50 days of age in Wistar-Furth rats.Objective: We aimed to determine whether BPA exposure of dams during gestation only or throughout lactation affects the incidence of mammary gland neoplasia in female offspring.Methods: We treated pregnant Sprague-Dawley rats with BPA at 0, 0.25, 2.5, 25, or 250 μg BPA/kg BW/day from gestational day (GD) 9 to birth and from GD9 to postnatal day (PND) 21. Mammary glands from BPA-exposed offspring were examined at four time points for preneoplastic and neoplastic lesions. To assess circulating BPA levels, we exposed pregnant rats to vehicle or 250 μg BPA/kg BW/day during gestation only or during gestation/lactation and analyzed sera from dams, fetuses, and nursing pups for total and unconjugated BPA.Results: Total and unconjugated BPA were detected in sera from 100% of dams and fetuses and 33% of pups exposed to 250 μg BPA/kg BW/day. Unconjugated BPA levels in exposed dams and fetuses (gestational) and in exposed dams and pups (gestational/lactational) were within levels found in humans. Preneoplastic lesions developed in BPA-exposed female offspring across all doses as early as PND50. Unexpectedly, mammary gland adenocarcinomas developed in BPA-exposed offspring by PND90.Conclusions: Our findings suggest that developmental exposure to environmentally relevant levels of BPA during gestation and lactation induces mammary gland neoplasms in the absence of any additional carcinogenic treatment. Thus, BPA may act as a complete mammary gland carcinogen.Citation: Acevedo N, Davis B, Schaeberle CM, Sonnenschein C, Soto AM. 2013. Perinatally administered bisphenol A acts as a mammary gland carcinogen in rats. Environ Health Perspect 121:1040–1046; http://dx.doi.org/10.1289/ehp.1306734
DIAGNOSIS OF CHRONIC AORTO-ILIAC OCCLUSIVE ARTERIAL DISEASE
Authors: E A HINES
Journal: Annals of Internal Medicine (1959)

Article1 October 1959DIAGNOSIS OF CHRONIC AORTO-ILIAC OCCLUSIVE ARTERIAL DISEASEEDGAR A. HINES JR., M.D., F.A.C.P.EDGAR A. HINES JR., M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-51-4-679 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe syndrome of chronic aorto-iliac occlusive arterial disease begins when the occlusive process impairs the flow of blood enough to cause clinically recognizable symptoms and signs of arterial insufficiency. The occlusion usually results from a thrombus superimposed upon an area of localized atheroma formation. Occasionally, large atheromas only partially occlude the lumen but produce enough functional narrowing to cause symptomatic arterial insufficiency. The most common symptom of arterial insufficiency is intermittent claudication, which is characterized by distress induced by exercise, usually walking, and is relieved within minutes by stopping and standing, if not by just slowing the pace.This syndrome...Bibliography1. MassarelliEstes JJJE: Atherosclerotic occlusion of the abdominal aorta and iliac arteries: a study of 105 patients, Ann. Int. Med. 47: 1125, 1957. LinkGoogle Scholar2. JuergensHinesBarkerSchadt JLEANWDC: Personal communication to the author. Google Scholar3. GibersonWaughHinesFaulconer RGJMEAA: Chronic occlusive disease of the terminal aorta and its surgical treatment: report of case, Proc. Staff Meet., Mayo Clin. 29: 137, 1954. MedlineGoogle Scholar4. Hines EA: Clinical aspects of arteriosclerotic aneurysm and arteriosclerotic occlusion of the abdominal aorta, Minnesota Med. 38: 836; 879, 1955. MedlineGoogle Scholar5. Estes JE: Surgical therapy of occlusive peripheral atherosclerosis, Angiology 9: 114, 1958. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Rochester, Minnesota*Received for publication May 16, 1959.Presented at the Fortieth Annual Session of The American College of Physicians, Chicago, Illinois, April 24, 1959.From the Section of Medicine, Mayo Clinic and Mayo Foundation, Rochester, Minnesota. The Mayo Foundation is a part of the Graduate School of the University of Minnesota.Requests for reprints should be addressed to the Section of Publications, Mayo Clinic, Rochester, Minnesota. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byEndovascular Aorto-Iliac Reconstruction vs. Aortobifemoral Bypass as First Choice for a Durable Revascularization for Aorto-Iliac Occlusive Disease 1 October 1959Volume 51, Issue 4Page: 679-685KeywordsAortaAtheromasBloodExerciseGraduate medical educationPenisSigns and symptomsThrombosisWalking ePublished: 1 December 2008 Issue Published: 1 October 1959 PDF downloadLoading ...
Obstetric and Gynecologic Milestones: Essays in Eponymy.
Authors: Alexander Brunschwig
Journal: Annals of Internal Medicine (1960)

This is a most interesting volume composed of 79 essays each briefly dealing with the originator of or contributor to an advance in the field of gynecology and obstetrics.The criterion for any personality to be included in this volume seems to be that his name has become attached to an anatomical structure, instrument, sign, or operation.For example, the pattern is set by the first essay which deals with Gabriello Fallopio, presumably because of the term "fallopian tube."A concise and interesting account of the pertinent historical setting is related and a brief resume of the life and personality of Fallopio is given, together with an available drawing (or, later, a photograph) and the repro- duction of the first page of the article relating his major contribution (in this case the description of the fallopian tube).The author is to be most highly commended for his exhaustive work in assembling the material and the illustrations published in this volume.To choose at random from some of the titles of other essays, one may mention Casper Bartholin and the Bartholin Glands, James Douglas and the peritoneal cul-de-sac, Thomas Wharton and the Jelly of the Umbilical Cord, Alfred Hegar and Hegar's Sign and Dilator, Ernst Wertheim and the Wertheim Operation
Abstract 17506: A Young Man with a Great Fall: Putting the Pieces Together
Authors: Monique S Tanna, William Slater
Journal: Circulation (2014)

A 35 year-old-male with hypertension and schizoaffective disorder presented with a first episode of non-prodromal syncope and traumatic fall resulting in a mandibular fracture. Physical examination revealed orthostatic tachycardia, normal cardiovascular examination, and no abnormalities with carotid sinus massage. Electrocardiogram showed NSR at 66 bpm, a single PVC, QTc interval 493 ms, and abnormal ST-T wave contour in V2-V3. Laboratory evaluation revealed normal electrolytes, mildly elevated troponin (0.763), and no leukocytosis. Postural orthostatic tachycardia syndrome was considered unlikely given that syncope did not occur after prolonged standing, and that his use of trazodone and risperidone can both cause orthostatic tachycardia. Transthoracic echocardiography (TTE) revealed decreased systolic function (EF 45%), paradoxical septal motion, normal LV wall thickness, and no valvular disease. Cardiac MRI showed moderate biventricular systolic dysfunction, LVEF 43%, RVEF 33%, mild 4-chamber dilatation, and a small pericardial effusion. Mild T2 hyperintensity in the mid-ventricular septum and anteroseptum, and scattered foci of patchy delayed gadolinium enhancement within the mid-anteroseptal, anterior and anterolateral LV segments were consistent with acute myocarditis. The reported prevalence of myocarditis among patients with sudden death is highly variable and ranges from 2-42%. Various types of myocarditis are associated with arrhythmias, including lymphocytic myocarditis which was the likely diagnosis in our patient. Despite lack of guideline recommendations, we opted to protect our patient with a wearable cardioverter-defibrillator given case reports of successful use for recurrent malignant arrhythmias in myocarditis. Follow-up TTE two months later was normal with EF 60%. Although syncope in the younger population is often appropriately attributed to a neurally-mediated etiology, the current case highlights the need for clinicians to be attuned to the possibility of subclinical myocarditis causing malignant arrhythmias in this setting, in which case the patient may be at risk for recurrent arrhythmia and sudden death and may benefit from the use of a wearable cardioverter-defibrillator.
Abstract 13477: The Effect of Right Ventricular Pacing on Right Ventricular Function and Tricuspid Regurgitation in Right Ventricular Apical Pacing vs Non-apical Pacing
Authors: Makoto Saito, Kazuaki Negishi, Gerry Kaye, Thomas H Marwick
Journal: Circulation (2014)

Background: Although right ventricular (RV) pacing is associated with LV dysfunction and dyssynchrony, the effect of pacing on RV function is unknown. RV lead-induced significant tricuspid regurgitation (TR) is associated with adverse outcome. We sought to investigate the effect of pacing on RV function, RV synchrony, and TR, and their association with global LV myocardial deformation. Methods: We enrolled 145 pts (76 RV apical (RVA) and 69 non-RVA pacing) with preserved ejection fraction and pacemaker implantation because of atrioventricular block (ProtectPACE study). Echo was performed at baseline (just after the implantation) and at 2 years. Tricuspid annular plane systolic excursion (TAPSE), time difference between time to peak TAPSE and time to peak mitral annular plane systolic excursion (TAPSE-dif), visual grading of TR, TR vena contracta (TRVC), and TR peak pressure gradient (TRPG) were assessed. We also measured global longitudinal strain (GLS) using speckle tracking. Results: Although visual TR ...
New courts offer treatment for drug offenders
Authors: Doug Payne
Journal: BMJ (2001)

A pilot court scheme offering supervision and treatment rather than incarceration for non-violent drug offenders is under way in Dublin, but without the cooperation of GPs in the area who dispense methadone to heroin addicts.

It is expected that as many as 100 offenders could be offered an integrated programme of rehabilitation, detoxification, counselling, training, and education under the scheme, which began this week. An independent team of examiners is assessing the project. If it is judged successful, it will be extended to other locations.

A …
Abstract 4223: Combined PI3K-AKT and MEK-ERK pathway inhibition provides broad antitumor efficacy in HER2+ breast tumor models
Authors: Pradip De, Yuliang Sun, Jennifer Carlson, Lori Friedman, Nandini Dey, Brian Leyland-Jones
Journal: Cancer Research (2014)

Abstract Background: The PI3K-AKT-mTOR and the RAS-RAF-MEK-ERK pathways are thought to be the central transducers of oncogenic signals in cancer. Combined targeting of these two pathways may be necessary for optimal therapeutic activity in solid tumors. This study evaluated the PI3K inhibitor GDC-0941, the MEK1/2 inhibitor GDC-0973 and the combination of both in different HER2+ breast cancer cell lines. Methodology: Growth inhibition/survival, apoptosis, signal transduction and antitumor efficacy were examined using MTT assays, 3D-ON-TOP assays, annexinV staining and mouse xenografts respectively, in BT474 (trastuzumab sensitive), BT474HR (trastuzumab-resistant) and HCC1954 (PIK3CA mutated) breast cancer cell lines. Results: (1) GDC-0941 and GDC-0973 exhibited in vitro cell killing activity in MTT assays with IC50's ranging from 0.35 µM to 1 µm and from 8 µM to 20 µM respectively, (2) the initiation of apoptotic activity (annexin V) in GDC-0941 plus GDC-0973 was significantly superior to that of either drug alone, (3) inhibition of phosphorylation of AKT(S473, T308), P70S6K, S6RP, and 4EBP1(T37/46) was observed following GDC-0941 treatment, and the combination of GDC-0941 plus GDC-0973 more effectively blocked p-S6RP and p-4EBP1, especially in BT474HR and HCC1954 cells, (4) GDC-0973 abrogated activation of ERK, and this ERK inactivation was sustained when combined with GDC-0941, (5) a combination of GDC-0941 and GDC-0973 more effectively blocked 3D-ON-TOP clonogenic growth of HER2+ cells than either agent alone, and (6) xenograft data show that the combination of GDC-0941 and trastuzumab has an enhanced anti-tumor effect in both sensitive (almost 100%) and resistant models (85%), and tumor regression was observed in both sensitive and resistant models when mice were treated with GDC-0941 plus GDC-0973 plus trastuzumab. Conclusions: Therapy with dual PI3K and MEK combination is more efficient than with either drug alone in all three cell lines. Our data provide stronger evidence that the addition of MEK inhibitor along with pan-PI3K inhibitor to HER2-directed treatment could augment the clinical benefit in breast cancer patients. Citation Format: Pradip De, Yuliang Sun, Jennifer Carlson, Lori Friedman, Nandini Dey, Brian Leyland-Jones. Combined PI3K-AKT and MEK-ERK pathway inhibition provides broad antitumor efficacy in HER2+ breast tumor models. [abstract]. In: Proceedings of the 105th Annual Meeting of the American Association for Cancer Research; 2014 Apr 5-9; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2014;74(19 Suppl):Abstract nr 4223. doi:10.1158/1538-7445.AM2014-4223
Skin Man Three
Authors: Mary Kennan Herbert
Journal: JAMA (1999)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Some Remarks on the Etymological and Grammatic Aspects of the Term ‘Alexithymia’
Authors: George Spyros Philippopoulos
Journal: Psychotherapy and Psychosomatics (1977)

Other Types| February 16 2010 Some Remarks on the Etymological and Grammatic Aspects of the Term 'Alexithymia' / Discussion Subject Area: Psychiatry and Psychology George Spyros Philippopoulos George Spyros Philippopoulos Athens Search for other works by this author on: This Site PubMed Google Scholar Psychother Psychosom (1977) 28 (1-4): 68–72. https://doi.org/10.1159/000287045 Article history Published Online: February 16 2010 Content Tools Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Facebook Twitter LinkedIn Email Tools Icon Tools Get Permissions Cite Icon Cite Search Site Citation George Spyros Philippopoulos; Some Remarks on the Etymological and Grammatic Aspects of the Term 'Alexithymia' / Discussion. Psychother Psychosom 31 December 1977; 28 (1-4): 68–72. https://doi.org/10.1159/000287045 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAll JournalsPsychotherapy and Psychosomatics Search Advanced Search Article PDF first page preview Close Modal This content is only available via PDF. 1977Copyright / Drug Dosage / DisclaimerCopyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher.Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. You do not currently have access to this content.
Abstract 5788: The Incidence and Health Economic Burden of Critical Limb Ischemia and Ischemic Amputation in Minnesota: 2005–2007
Authors: James M Peacock, Hong H Keo, Xinhua Yu, Niki Oldenburg, Sue Duval, Timothy D Henry, Michael R Jaff, Iris Baumgartner, Alan T Hirsch
Journal: Circulation (2009)

Background: Critical limb ischemia (CLI) is the most severe manifestation of peripheral artery disease (PAD) and is associated with high rates of morbidity and mortality, including subsequent myocardial infarction, stroke, and amputation. Nevertheless, the annual incidence of CLI in the United States is not known and there is no active national surveillance. Methods: We have estimated the incidence of ischemic amputation using all inpatient hospital discharge claims in Minnesota. These claims represent approximately 97% of hospitalizations in the state. Major and minor ischemic amputations were identified through ICD-9 procedure codes for lower limb amputation not due to trauma or cancer. This coding algorithm can be applied to other state-based hospitalization claims databases. Results: The age-adjusted incidence of ischemic amputation in 2007 was 18.8 (95% C.I. 17.7–19.9) per 100,000 (n=1,038). Amputations increased significantly with age and were more than twice as high in men as in women (25.1 vs. 11.3 per 100,000). The incidence of amputation did not differ significantly by rural or urban residence. Of these hospitalizations, 45% were for major above ankle leg amputations. The mean total charge for each hospitalization was $53,726, with cumulative charges for ischemic amputation hospitalizations of $56.2 million statewide in 2007. The incidence of ischemic amputation is significant as it represents approximately half of the annual stroke mortality rate (36.2 per 100,000 in 2007) with total charges approximately 20% of those for annual stroke hospitalizations. Applying this incidence and these charges for ischemic amputation in Minnesota to the entire US population in 2008 yields an estimate of more than 57,000 amputations and hospitalization costs of $3.1 billion. Conclusion: Ischemic amputation represents only the most severe CLI clinical event and underestimates the total burden of CLI and severe PAD. The incidence of ischemic amputation remains high, and results in major morbidity and health economic costs. These data permit the first population-based estimate of ischemic amputation in the USA in a non-selected population at risk.