tbuckley/cabot-search huggingface dataset:
Thallium-Pertechnetate Subtraction Scanning in the Preoperative Localization of an Ectopic Undescended Parathyroid Gland
Authors: James Frydman, Jesus Bianco, Marc Drezner, Herbert Chen
Journal: Clinical Nuclear Medicine (2004)

Although bilateral exploration is highly effective in the treatment of primary hyperparathyroidism, minimally invasive parathyroidectomy has evolved into the procedure of choice when a single parathyroid lesion can be localized preoperatively. In this article, we discuss the utilization of thallium-pertechnetate subtraction scanning (TPSS) after technetium Tc-99m sestamibi scintigraphy failed to localize an ectopic parathyroid adenoma. Subsequently, radioguided resection of an undescended parathyroid adenoma inferior to the left submandibular gland was performed with surgical cure after a single procedure. This case report illustrates the importance of TPSS as a second-line modality in preoperative adenoma localization, thereby using minimally invasive techniques to successfully treat this patient's primary hyperparathyroidism.
Conjugated Estrogens (CE) and Oral Contraceptives (OCP) in Relation to Renin Activity and Blood Pressure.
Authors: Milton G. Crane
Journal: Annals of Internal Medicine (1970)

Meeting Abstracts1 May 1970Conjugated Estrogens (CE) and Oral Contraceptives (OCP) in Relation to Renin Activity and Blood Pressure.Milton G. Crane, M.D., F.A.C.P., John J. Harris, M.D., F.A.C.P., William G. Winsor III, M.D.Milton G. Crane, M.D., F.A.C.P.Search for more papers by this author, John J. Harris, M.D., F.A.C.P.Search for more papers by this author, William G. Winsor III, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-72-5-789_1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTwenty-one patients have been studied who developed hypertension (blood pressure 150/100) while taking oral contraceptives (OCP). Seventeen became normotensive (blood pressure 145/95) without antihypertensive medication in from 1 week to 12 months after stopping the drug. Average blood pressure before, during, and when the blood pressure was stabilized after stopping the OCP was 126/76, 190/110, and 130/91, respectively. In 11 patients tested the average plasma renin activity (PRA) (in response to sodium restriction and standing), the renin substrate (PRS), and aldosterone excretion rate (AES) were slightly to moderately elevated while the patients were on the OCP and decreased significantly (P... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Loma Linda, Calif. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 May 1970Volume 72, Issue 5Page: 789-789KeywordsAldosteroneBlood pressureDrugsEstrogensExcretionHypertensionOral contraceptive therapyPatientsPlasma renin activitySodium Issue Published: 1 May 1970 PDF DownloadLoading ...
Detection of Phenylketonuria in Newborn Infants
Authors: Helen K. Berry
Journal: JAMA (1966)

The purpose of screening infants for the presence of phenylketonuria is to permit early treatment and thus reduce the risk of mental retardation associated with this disease. It has been assumed that the chief problem lay in detection of this rare disorder, and the difficulties and hazards of treatment have not been emphasized. Death as a result of overtreatment of phenylketonuria has occurred. Growth failure, anemia, and rachitic bone changes are also described in treated children, presumably the result of phenylalanine deficiency. Mild to moderate mental retardation has been reported in infants who were treated by severe restriction of phenylalanine intake in spite of early detection of the disease. It should be recognized that the detection of phenylketonuria in an infant is but the first step in a long-term treatment program if mental retardation is to be prevented. The most critical period of treatment comes during the first six months
Patent Foramen Ovale and Migraine
Authors: Tatjana Rundek, Mitchell S.V. Elkind, Marco R. Di Tullio, Emmanuel Carrera, Zhezhen Jin, Ralph L. Sacco, Shunichi Homma
Journal: Circulation (2008)

A causal relationship between patent foramen ovale (PFO) and migraine has been hypothesized, and improvement of migraine frequency and severity after percutaneous PFO closure has been reported. Population-based data on the relationship between PFO and migraine are sparse, however. The objective of this study was to examine the association between PFO and migraine among stroke-free individuals in an urban, population-based, multiethnic cohort.As a part of the ongoing Northern Manhattan Study (NOMAS), 1101 stroke-free subjects were assessed for self-reported history of migraine. The presence of PFO was assessed by transthoracic echocardiography. The mean age of the group was 69+/-10 years; 58% were women. Forty-eight percent were Caribbean Hispanic, 24% were white, 26% were black, and 2% were another race/ethnicity. The prevalence of self-reported migraine was 16% (13% migraine with aura). The prevalence of PFO was 15%. Migraine was significantly more frequent among younger subjects, women, and Hispanics. The prevalence of PFO was not significantly different between subjects who had migraine (26/178, or 14.6%) and those who did not (138/923, or 15.0%; P=0.9). In an adjusted multivariate logistic regression model, the presence of PFO was not associated with increased prevalence of migraine (odds ratio 1.01, 95% confidence interval 0.63 to 1.61). Increasing age was associated with lower prevalence of migraine in both subjects with a PFO (odds ratio 0.94, 95% confidence interval 0.90 to 0.99 per year) and those without PFO (odds ratio 0.97, 95% confidence interval 0.95 to 0.99 per year). The observed lack of association between PFO and migraine (with or without aura) was not modified by diabetes mellitus, hypertension, cigarette smoking, or dyslipidemia.In this multiethnic, elderly, population-based cohort, PFO detected with transthoracic echocardiography and agitated saline was not associated with self-reported migraine. The causal relationship between PFO and migraine remains uncertain, and the role of PFO closure among unselected patients with migraine remains questionable.
219. Persistent Correction of Hyperphenylalaninemia Following Liver-Directed, rAAV2/8-Mediated Gene Therapy for Murine Phenylketonuria (PKU)
Authors: Cary O. Harding, Melanie B. Gillingham, Elizabeth Daghighi, Andrew Bird, Dwight D. Koeberl
Journal: Molecular Therapy (2006)

Top of pageAbstract
We recently reported the complete correction of hyperphenylalaninemia in Pahenu2 mice, a model of human phenylketonuria (PKU), following portal vein injection of a rAAV2/ 8 vector expressing the mouse phenylalanine hydroxylase (PAH) cDNA under the control of a strong liver specific (LSP) promoter. Our goal now is to evaluate the persistence of this effect following a single vector injection. Three hyperphenylalaninemic Pahenu2 mice (two female, one male) each received 5 X 1011 vector genomes (vg) of mouse PAH-expressing rAAV2/8 via portal vein injection. An additional two animals (one male, one female) received saline via portal vein injection only. Serum phenylalanine (PHE) levels decreased significantly by two weeks post injection in rAAV2/8 treated mice (mean preinjection serum PHE |[plusmn]| SE = 2074 |[plusmn]| 157 |[mu]|M vs. 150 |[plusmn]| 49.9 |[mu]|M two weeks post injection, p = 0.001; normal =157 |[plusmn]| 32 |[mu]|M), while serum PHE levels remain unchanged in saline treated controls. This effect has persisted out to 32 weeks post injection although serum PHE has increased modestly over time in the two rAAV2/8-treated female mice. The mean serum PHE level in rAAV2/8-treated mice 32 weeks after treatment was 630 |[mu]|M, still a significant decrease from preinjection levels. Body weight and physical appearance of the animals have remained normal followingrAAV2/8 treatment except or the expected increase in coat pigmentation following correction of lood PHE levels. Liver-directed, rAAV2/8 vector-mediated gene therapy has successfully corrected hyperphenylalaninemia in Pahenu2, but the stability of expression and the incidence of long-term adverse effects must continue to be evaluated.
Concentration of Insulin Autoantibodies at Onset of Type I Diabetes: Inverse Log-Linear Correlation With Age
Authors: Pnina Vardi, Anette G Ziegler, Joan H Mathews, Sergio Dib, Richard J Keller, Alyne T Ricker, Joseph Wolfsdorf, Raymonde D Herskowitz, Albert Rabizadeh, George S Eiswnbarth, J Stuart Soeldner
Journal: Diabetes Care (1988)
Long-term Outcome of Primary Percutaneous Coronary Intervention vs Prehospital and In-Hospital Thrombolysis for Patients With ST-Elevation Myocardial Infarction
Authors: Ulf Stenestrand, Johan Lindbäck, Lars Wallentin, for the RIKS-HIA Registry
Journal: JAMA (2006)

Whether the superior results of percutaneous coronary intervention (PCI) reported in clinical trials in which patients with ST-segment elevation myocardial infarction (STEMI) received reperfusion treatment can be replicated in daily practice has been questioned, especially whether it is superior to prehospital thrombolysis (PHT).To evaluate the outcome of different reperfusion strategies in consecutive STEMI patients.A prospective observational cohort study of 26 205 consecutive STEMI patients in the Register of Information and Knowledge about Swedish Heart Intensive Care Admissions (RIKS-HIA) who received reperfusion therapy within 15 hours of symptom onset. The registry includes more than 95% of all Swedish patients, of all ages, who were treated in a coronary intensive care unit between 1999 and 2004.Seven thousand eighty-four patients underwent primary PCI; 3078, PHT; and 16 043, in-hospital thrombolysis (IHT).Mortality, reinfarction, and readmissions as reported in the National Health Registries through December 31, 2005.After adjusting for younger age and less comorbidity, primary PCI was associated with lower mortality than IHT at 30 days (344 [4.9%] vs 1834 [11.4%]; hazard ratio [HR], 0.61; 95% confidence interval [CI], 0.53-0.71) and at 1 year (541 [7.6%] vs 2555 [15.9%]; HR, 0.68; 95% CI, 0.60-0.76). Also primary PCI correlated with lower mortality than PHT at 30 days (344 [4.9%] vs 234 [7.6%]; HR, 0.70; 95% CI, 0.58-0.85) and 1 year (541 [7.6%] vs 317 [10.3%]; HR, 0.81; 95% CI, 0.69-0.94). Prehospital thrombolysis predicted a lower mortality than IHT at 30 days (HR, 0.87; 95% CI, 0.76-1.01) and at 1 year (HR, 0.84; CI 0.74-0.95). Beyond 2 hours' treatment delay, the observed mortality reductions with PHT tended to decrease while the benefits with primary PCI seemed to remain regardless of time delay. Primary PCI was also associated with shorter hospital stay and less reinfarction than either PHT or IHT.In unselected patients with STEMI, primary PCI, which compared favorably with IHT and PHT, was associated with reduced duration of hospital stay, readmission, reinfarction, and mortality.
Separation of the Modular Stent-Graft Within the Abdominal Aortic Aneurysm
Authors: Nai-Wen Tsao, Chun-Ming Shih, Feng-Yen Lin, Wen-Tein Shao, Chi-Ming Lee, Keng-Liang Ou, Nein-Chun Chang, Chun-Yao Huang
Journal: Journal of the American College of Cardiology (2011)
Study Indicates Utility for New Breast Cancer Prognostic Marker
Authors: Joan Stephenson
Journal: JAMA (2001)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Neurologic Prognosis after Cardiac Arrest
Authors: G. Bryan Young
Journal: New England Journal of Medicine (2009)

A 55-year-old man collapses while jogging through the park. A bystander finds him unconscious and without a pulse and initiates cardiopulmonary resuscitation while an ambulance is summoned. On arrival in the emergency room, the patient is in ventricular fibrillation. Spontaneous circulation is reestablished, but he remains comatose with absent pupillary reflexes. He remains unconscious after treatment with hypothermia for 24 hours. What would you advise regarding his neurologic prognosis?
Prediction of Rebleeding in Peptic Ulcers by Visual Stigmata and Endoscopic Doppler Ultrasound Criteria
Authors: G. M. Fullarton, W. R. Murray
Journal: Endoscopy (1990)

Following peptic ulcer hemorrhage, the ability to accurately determine those patients at highest risk of rebleeding relies on clinical and endoscopic criteria which are accurate in only a variable proportion of cases. In this study we have assessed prediction of rebleeding in peptic ulcers using a transendoscopic vascular detector (TVD) to compare the presence of a positive Doppler signal in relation to an ulcer base with visual stigmata of recent hemorrhage (SRH). Of 711 patients endoscoped for upper GI hemorrhage over an 18-month period 180 (25 %) were found to have a peptic ulcer. One hundred and twenty-four had either minor or no SRH at the time of endoscopy, and none of these patients rebled. Fifty-six patients had a single peptic ulcer with either active hemorrhage, a visible vessel or adherent clot, and 22 were entered into the trial. Overall, 9 patients (41 %) in this group rebled. Considering prediction of rebleeding, visible vessels had a sensitivity of 89 % and specificity of 92 % compared with a positive Doppler signal sensitivity of 87 % and specificity of 86 %. These results suggest that the TVD can predict rebleeding in peptic ulcers with an accuracy similar to that of endoscopic identification of a visible vessel.
The elderly in a coronary unit.
Authors: B O Williams, T B Begg, T Semple, J B McGuinness
Journal: BMJ (1976)

The clinical features of myocardial infarction were compared in 104 patients over the age of 70 and 399 younger patients admitted to a coronary care unit. Absence of an age bar at 70 years has increased the number of admission to the unit by 24%, and the number of patients with proved infarcts by 26%. Severe complications are more common and mortality is doubled in the elderly. Although immediate management of primary ventricular fibrillation is as successful in older as in younger patients, treatment of the elderly with less dramatic conditions is less successful. The elderly survivors tend to spend longer in the coronary unit and subsequently in the general medical ward.
RAISED NEURON-SPECIFIC ENOLASE IN SERUM OF CHILDREN WITH METASTATIC NEUROBLASTOMA
Authors: PaulM. Zeltzer, AlexandraM. Parma, Andree Dalton, StuartE. Siegel, PaulJ. Marangos, Harland Sather, Denman Hammond, RobertC. Seeger
Journal: The Lancet (1983)
Bed Worship — An Ethical Vow for Scientists — Doctor, Please
Authors: John Lister
Journal: New England Journal of Medicine (1971)

THE source of the somewhat startling headline, "Bed worship wrong, hospitals told," that recently appeared in a daily newspaper was traced to the journal Hospital Management. In fact the phrase bed worship was extracted from the editorial in an issue devoted to a study of the many new experiments in ward design and patient care that are now taking place. Under the title, "The Quiet Revolution in Hospital Practice,"1 the writer claimed that in the National Health Service there is a growing disinclination to accept that the hospital service should dominate the health scene. The hospital service would still require . . .
A Dose Finding Study of Weekly and Every-3-Week nab-Paclitaxel Followed by Carboplatin as First-Line Therapy in Patients with Advanced Non-small Cell Lung Cancer
Authors: Mark A. Socinski, Georgiy M. Manikhas, Daniil L. Stroyakovsky, Anatoly N. Makhson, Sergey V. Cheporov, Sergei V. Orlov, Petr K. Yablonsky, Paul H. Bhar, Jose Iglesias
Journal: Journal of Thoracic Oncology (2010)
Suppressor-Cell Function and Autoimmunity
Authors: Reuben Maverick Falkoff, John F. Scavulli
Journal: Annals of Internal Medicine (1978)

Letters and Corrections1 September 1978Suppressor-Cell Function and AutoimmunityREUBEN MAVERICK FALKOFF, JOHN F. SCAVULLIREUBEN MAVERICK FALKOFFSearch for more papers by this author, JOHN F. SCAVULLISearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-89-3-426_1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: Dr. Krakauer (Disorders of the Suppressor-Cell System in Autoimmunity Ann Intern Med 88:233-237, 1978) has presented data he interprets as showing that an age-related loss of suppressor-T-cell function leads to the autoimmune disease of NZB mice. We offer an alternate explanation that is consistent with his data and has very different therapeutic implications.Dr. Krakauer's key observation is that concanavalin A-stimulated T-cells from mature NZB/W mice fail to suppress poke-weed mitogen-stimulated immunoglobulin synthesis. We have previously shown that concanavalin A stimulates not only suppressive but also enhancing effects on antibody synthesis and that these effects are competitive...References1. SCAVULLIDUTTON JR: Competition between concanavalin A induced stimulatory and inhibitory effects in the in vitro immune response to antigen. J Exp Med 141:524-529, 1975 CrossrefMedlineGoogle Scholar2. RAEDERFREIMERPANSKYSENITZER REBD: Response of peripheral blood lymphocytes from the (NZB/NZW)F1 mouse to phytohemag-glutinin. Clin Immunol Immunopathol 6:174-181, 1976 CrossrefMedlineGoogle Scholar3. PALMERDAUPHINEEMURPHYTALAL DMEN: Hyperactive T-cell function in young NZB mice. Clin Exp Immunol 23:578-581, 1976 MedlineGoogle Scholar4. DUTTONFALKOFFHISRTHOFFMANKAPPLERKETTMANLESLEYVANN RRJMJJJD: Is there evidence for a non-antigen specific diffusable mediator from the thymus-derived cell in the initiation of the immune response? Prog Immunol 1:355-368, 1971 CrossrefGoogle Scholar5. FIALKOWGILCHRISTALLISON PCA: Autoimmunity in chronic graft-versus-host disease. Clin Exp Immunol 13:479-486, 1973 MedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 September 1978Volume 89, Issue 3Page: 426-426KeywordsAutoimmune diseasesAutoimmunity Issue Published: 1 September 1978 PDF downloadLoading ...
Homecoming Without You, Lauren
Authors: David Nadal Moolten
Journal: JAMA (1985)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Gastropathy Due to Celecoxib, a Cyclooxygenase-2 Inhibitor
Authors: Suneel Mohammed, Dorwyn W. Croom
Journal: New England Journal of Medicine (1999)

To the Editor: Celecoxib (Celebrex), a cyclooxygenase (COX)-2–specific nonsteroidal antiinflammatory drug (NSAID), was recently introduced in the U.S. market. COX-2 is induced in inflammation, wher...
Synthesis and characterization of electroactive and biodegradable ABA block copolymer of polylactide and aniline pentamer
Authors: Lihong Huang, Jun Hu, Le Lang, Xin Wang, Peibiao Zhang, Xiabin Jing, Xianhong Wang, Xuesi Chen, Peter I. Lelkes, Alan G. MacDiarmid
Journal: Biomaterials (2007)
Continental Divide? The Attitudes of US and Canadian Oncologists on the Costs, Cost-Effectiveness, and Health Policies Associated With New Cancer Drugs
Authors: Scott R. Berry, Chaim M. Bell, Peter A. Ubel, William K. Evans, Eric Nadler, Elizabeth L. Strevel, Peter J. Neumann
Journal: Journal of Clinical Oncology (2010)

Oncologists in the United States and Canada work in different health care systems, but physicians in both countries face challenges posed by the rising costs of cancer drugs. We compared their attitudes regarding the costs and cost-effectiveness of medications and related health policy.Survey responses of a random sample of 1,355 United States and 238 Canadian medical oncologists (all outside of Québec) were compared.Response rate was 59%. More US oncologists (67% v 52%; P < .001) favor access to effective treatments regardless of cost, while more Canadians favor access to effective treatments only if they are cost-effective (75% v 58%; P < .001). Most (84% US, 80% Canadian) oncologists state that patient out-of-pocket costs influence their treatment recommendations, but less than half the respondents always or frequently discuss the costs of treatments with their patients. The majority of oncologists favor more use of cost-effectiveness data in coverage decisions (80% US, 69% Canadian; P = .004), but fewer than half the oncologists in both countries feel well equipped to use cost-effectiveness information. Majorities of oncologists favor government price controls (57% US, 68% Canadian; P = .01), but less than half favor more cost-sharing by patients (29% US, 41% Canadian; P = .004). Oncologists in both countries prefer to have physicians and nonprofit agencies determine whether drugs provide good value.Oncologists in the United States and Canada generally have similar attitudes regarding cancer drug costs, cost-effectiveness, and associated policies, despite practicing in different health care systems. The results support providing education to help oncologists in both countries use cost-effectiveness information and discuss drug costs with their patients.