γδ T Cells in Asthma
Authors: Milton D. Rossman
Journal: Annals of Internal Medicine (1996)

Editorials15 January 1996γδ T Cells in AsthmaMilton D. Rossman, MD and Simon R. Carding, MDMilton D. Rossman, MDUniversity of Pennsylvania School of Medicine Philadelphia, PA 19104Search for more papers by this author and Simon R. Carding, MDUniversity of Pennsylvania School of Medicine Philadelphia, PA 19104Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-124-2-199601150-00013 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail In this issue of Annals, Spinozzi and colleagues [1] report their observations on γδ T cells in the lungs of asthmatic patients. This is the first report of increased γδ T cells in the bronchoalveolar fluid from patients with asthma. Although they did not detect any γδ T cells in samples from the lungs of their controls or from patients with sarcoidosis, extrinsic allergic alveolitis, cystic fibrosis, or anatomic malformations of the airways, the finding of increased γδ T cells in the blood or in lung samples in patients with sarcoidosis and extrinsic allergic alveolitis has been previously reported [2-4]. ...References1. Spinozzi F, Agea E, Bistoni O, Forenza N, Monaco A, Bassotti G, et al. Increased allergen-specific, steroid-sensitive γδ T cells in bronchoalveolar lavage fluid from patients with asthma. Ann Intern Med. 1996; 124:223-7. Google Scholar2. Raulf M, Liebers V, Steppert C, Baur X. Increased γ/δ-positive T-cells in blood and bronchoalveolar lavage of patients with sarcoidosis and hypersensitivity pneumonitis. Eur Respir J. 1994; 7:140-7. Google Scholar3. Tamura N, Holroyd KJ, Banks T, Kirby M, Okayama H, Crystal RG. 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Infect Immun. 1993; 61:113-6. Google Scholar15. Skeen MJ, Ziegler HK. Induction of murine peritoneal γδ T cells and their role in resistance to bacterial infection. J Exp Med. 1993; 178:971-84. Google Scholar16. Pawankar R, Okuda M, Asuma M, Suzuki KMS, Yagi T, Okumura K, et al. Characterization of nasal γδ T cells in perennial allergic rhinitis. J Allergy Clin Immunol. 1995; 95:190. Google Scholar17. McMenamin C, Pimm C, McKersey M, Holt PG. Regulation of IgE responses to inhaled antigen in mice by antigen-specific γδ T cells. Science. 1994; 265:1869-71. Google Scholar Author, Article, and Disclosure InformationAffiliations: University of Pennsylvania School of Medicine Philadelphia, PA 19104Grant Support: By NIH grant HL-51749.Corresponding Author: Milton D. Rossman, MD, Pulmonary and Critical Care, Room 814 East Gates Building, Hospital of the University of Pennsylvania, 3400 Spruce Street, Philadelphia, PA 19104-4283. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoIncreased Allergen-Specific, Steroid-Sensitive γδ T Cells in Bronchoalveolar Lavage Fluid from Patients with Asthma Fabrizio Spinozzi , Elisabetta Agea , Onelia Bistoni , Nicolino Forenza , Alessandro Monaco , Gabrio Bassotti , Ildo Nicoletti , Carlo Riccardi , Fausto Grignani , and Alberto Bertotto Metrics Cited byPhysical map of an asthma susceptibility locus in 7p15-p14 and an association study of TCRGCytokine Production by Vγ + -T-Cell Subsets Is an Important Factor Determining CD4 + -Th-Cell Phenotype and Susceptibility of BALB/c Mice to Coxsackievirus B3-Induced Myocarditis 15 January 1996Volume 124, Issue 2Page: 266-267KeywordsAntigensAsthmaCellsCytokinesHuman leukocyte antigenImmune responseInfectious diseasesLungsT cell receptorsT cells Issue Published: 15 January 1996 Copyright & PermissionsCopyright © 1996 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...