tbuckley/cabot-search huggingface dataset:
Noninvasive <i>De novo</i> Imaging of Human Embryonic Stem Cell–Derived Teratoma Formation
Authors: Feng Cao, Zibo Li, Andrew Lee, Zhaofei Liu, Kai Chen, Hui Wang, Weibo Cai, Xiaoyuan Chen, Joseph C. Wu
Journal: Cancer Research (2009)

Abstract Teratoma formation can be a serious drawback after the therapeutic transplantation of human embryonic stem (hES) cells. Therefore, noninvasive imaging of teratomas could be a valuable tool for monitoring patients undergoing hES cell treatment. Here, we investigated the angiogenic process within teratomas derived from hES cells and now report the first example of using 64Cu-labeled RGD tetramer (64Cu-DOTA-RGD4) for positron emission tomography imaging of teratoma formation by targeting αvβ3 integrin. H9 hES cells (2 × 106), stably expressing firefly luciferase, and enhanced green fluorescence protein (Fluc-eGFP) were injected into adult nude mice (n = 12) s.c. Eight weeks after transplantation, these hES cell grafts evolved into teratomas as confirmed by longitudinal bioluminescence imaging. Under micropositron emission tomography imaging, 2-deoxy-2-[18F]fluoro-D-glucose and 3′-deoxy-3′-[18F]-fluorothymidine both failed to detect hES cell–derived teratomas (0.8 ± 0.5 versus 1.1 ± 0.4 %ID/g, respectively; P = not significant versus background signals). By contrast, 64Cu-DOTA-RGD4 revealed specific and prominent uptake in vascularized teratoma and significantly lower uptake in control tumors (human ovarian carcinoma 2008 cell line), which had low intergrin expression (10.1 ± 3.4 versus 1.4 ± 1.2 %ID/g; P &amp;lt; 0.01). Immunofluorescence staining of CD31 and β3 integrin also supported our in vivo imaging results (P &amp;lt; 0.05). Moreover, we found that the cells dissociated from teratomas showed higher αvβ3 integrin expression than the 2008 cells. In conclusion, by targeting αvβ3 integrin, we successfully showed the ability of 64Cu-DOTA-RGD4 to noninvasively visualize teratoma formation in vivo for the first time. [Cancer Res 2009;69(7):2709–13]
STUDIES IN INTRAVASCULAR COAGULATION. II. A COMPARISON OF THE EFFECT OF DICUMAROL AND HEPARIN ON CLOT FORMATION IN ISOLATED VENOUS SEGMENTS 1
Authors: Stanford Wessler, Mary Theresa Connelly
Journal: Journal of Clinical Investigation (1953)

segments isolated for one and one-half hours (1), the failure of a clot to develop within 90 minutes after isola- tion of a segment
Massive haematuria associated with sickle-cell trait.
Authors: M. A. Bennett, R. W. Heslop, M. J. Meynell
Journal: BMJ (1967)

Abnormal Haemoglobins in Iran-Rahbar et al.MiDELtUR 677 cause a considerable difference in electrophoretic mobility when compared with haemoglobin A (Figs. 6 and7).Summary In two surveys, each of 100 non-anaemic patients in Shiraz, Iran, two examples of haemoglobin D Punjab were found.In a third survey of 400 anaemic patients in Teheran, thalassaemia, haemoglobin S, haemoglobin D, and haemoglobin C were found.In addition, a new haemoglobin, J Iran, a.j82 77 His->Asp, was discovered.One of us (S.R.) is indebted to Drs. H. Mirdamadi, Mefidi, and Roberts for their advice and co-operation.We should like to thank Mr. D. Irvine, who prepared the fingerprints of the haemoglobin D samples found in the Shiraz Survey.
Ultrasonographically assessed carotid atherosclerosis in Japanese type 2 diabetic patients: Role of nonesterified fatty acids
Authors: Ataru Taniguchi, Yoshikatsu Nakai, Mitsuo Fukushima, Satoshi Teramura, Ryuji Hayashi, Kenichi Hama, Keiichi Marumoto, Toshiki Watanabe, Ikuko Yoshioka, Kenji Sakaguchi, Hiroyuki Kishimoto, Katsuyo Matsushita, Takahide Okumura, Kumpei Tokuyama, Shoichiro Nagasaka, Masahiko Sakai
Journal: Metabolism (2002)
Hepatitis B virus DNA in the sera of HBsAg carriers: A marker of active hepatitis B virus replication in the liver
Authors: Ferruccio Bonino, Bill Hoyer, Judith Nelson, Ronald Engle, Giorgio Verme, John Gerin
Journal: Hepatology (1981)

Sera and liver biopsies from 30 Italian patients, carriers of HBsAg for at least 3 years, were examined for markers of hepatitis B virus (HBV) infection by serological assays and immunofluorescence. Biopsies were analyzed for HBcAg, HBsAg, and delta antigen by immunofluorescence; sera were assayed for HBsAg/anti-HBs, HBcAg/anti-HBc, HBeAg/anti-HBe, delta/anti-delta, HBV-specific DNA polymerase activity and the presence of HBV DNA. HBcAg, HBeAg, and DNA polymerase tests were positive in the sera of 71, 86, and 57%, respectively, of carriers with intrahepatic HBcAg. HBV DNA was detected in 100% of patients expressing HBcAg in the liver with a strong correlation between the concentration of serum DNA and the intensity of HBcAg immunofluorescence in the liver. HBV DNA was detected in the sera of 63% of carriers with intrahepatic delta where the other markers of HBV replication (HBeAg, DNA polymerase) were undetectable. The assay for serum HBV DNA appears to be an excellent noninvasive method for detecting active replication of HBV in HBsAg carriers.
Vasohibin: the feedback on a new inhibitor of angiogenesis
Authors: Robert S. Kerbel
Journal: Journal of Clinical Investigation (2004)

Angiogenesis is regulated in large part by the balance of various proangiogenic stimulators, such as VEGF, and a diverse group of endogenous inhibitors of angiogenesis, most of which are extrinsic to endothelial cells. With respect to the latter, until recently, none have appeared to be induced as a consequence of a specific, self-regulating, feedback inhibition response. A new inhibitor, called vasohibin, has been uncovered. Vasohibin is selectively induced in endothelial cells by proangiogenic stimulatory growth factors such as VEGF; it appears to operate as an intrinsic and highly specific feedback inhibitor of activated endothelial cells engaged in the process of angiogenesis.
Tumor Necrosis Factor-α Mediates Cardiac Remodeling and Ventricular Dysfunction After Pressure Overload State
Authors: Mei Sun, Manyin Chen, Fayez Dawood, Urszula Zurawska, Jeff Y. Li, Thomas Parker, Zamaneh Kassiri, Lorrie A. Kirshenbaum, Malcolm Arnold, Rama Khokha, Peter P. Liu
Journal: Circulation (2007)

Pressure overload is accompanied by cardiac myocyte apoptosis, hypertrophy, and inflammatory/fibrogenic responses that lead to ventricular remodeling and heart failure. Despite incomplete understanding of how this process is regulated, the upregulation of tumor necrosis factor (TNF)-alpha after aortic banding in the myocardium is known. In the present study, we tested our hypothesis that TNF-alpha regulates the cardiac inflammatory response, extracellular matrix homeostasis, and ventricular hypertrophy in response to mechanical overload and contributes to ventricular dysfunction.C57/BL wild-type mice and TNF-knockout (TNF-/-) mice underwent descending aortic banding or sham operation. Compared with sham-operated mice, wild-type mice with aortic banding showed a significant increase in cardiac TNF-alpha levels, which coincided with myocyte apoptosis, inflammatory response, and cardiac hypertrophy in week 2 and a significant elevation in matrix metalloproteinase-9 activity and impaired cardiac function in weeks 2 and 6. Compared with wild-type mice with aortic banding, TNF-/- mice with aortic banding showed attenuated cardiac apoptosis, hypertrophy, inflammatory response, and reparative fibrosis. These mice also showed reduced cardiac matrix metalloproteinase-9 activity and improved cardiac function.Findings from the present study have suggested that TNF-alpha contributes to adverse left ventricular remodeling during pressure overload through regulation of cardiac repair and remodeling, leading to ventricular dysfunction.
ELECTROSHOCK THERAPY IN HIGH-RISK PATIENTS
Authors: CARL P. MALMQUIST, JAMES H. MATTHEWS
Journal: American Journal of Psychiatry (1966)

The use of the procedure as practiced by the authors for allaying apprehension and reassuring the patient and physician is not considered a trivial indication. In the cases where we have used it for this purpose, it was probably one of the determining factors as to whether the patient would accept treatment on not. Secondly, the distressing muscular fasciculations and paralyses produced by the succinylcholine can lead the apprehensive patient to withdraw from treatment once begun. It must also be noted that in all of the cases where a decision is made to treat the patient in this manner, there is reassurance not only to the patient but to the physician, who must bear the responsibility in any case. Advantages in using this procedure in selected cases thus appear to outweigh the added expense and inconvenience. The main advantage would appear to be the opportunity to utilize EST in those patients expected to benefit from it coupled with the security the psychiatrist has in giving the treatment to those with an increased risk. It would seem that there is little reason why this procedure should not be extended and used routinely in all patients treated with EST. From maintenance of full oxygenation, hypoxia or anoxia is eliminated along with the risk of fractures or dislocations, thus extending treatment to borderline cases, such as those with cardiac disabilities and orthopedic problems. An added advantage is the freedom to individualize the dose of thiopental or succinylcholine according to the idiosyncratic reactions of certain patients and also to adjust this as treatments progress, which is occasionally needed(9).
THE COPPER AND NON-HEMOGLOBINOUS IRON CONTENTS OF THE BLOOD SERUM IN DISEASE 1
Authors: Arthur Locke, E. R. Main, D. O. Rosbash
Journal: Journal of Clinical Investigation (1932)

This is a report of an investigation into the extent to which the copper and non-hemoglobinous iron levels of the blood serum are shifted in dis- ease, and the extent to which the shifted levels may reflect underlying disturbances of tissue respiration and metabolism.The levels of copper and non-hemoglobinous iron in the blood serums of fasting individuals are determined by balances between the rates at which the metals are drawn or excreted from the cells and the rates at which they are excreted from the body.In the absence of changes in the rates at which the metals are excreted from the body, increased levels in the serum signify decreased levels within the cells, and vice versa.Increases in the copper content of normally respiring cells would ap- pear to be accompanied by a reduction in the intensity of their metabolism.The respiration of the unripe Arbacia egg decreases progressively as the content of copper increases.Following fertilization, the copper content becomes reduced, as the result of the excretion of a "copper- avid" substance into the supporting medium, and the rate of respiration rises (1).Additions of copper to cultures of baker's yeast are followed by proportionate decreases in the rates of respiration and glucolysis (2).Concentrations of copper equivalent to those present in human serums are not only partially inhibitory to respiration and glucolysis but also to proteolysis (3) (4) and lipolysis (5) (6) as encountered in the cells which make up mammalian tissue.Increases in the iron content of living cells would appear to be followed by an augmentation of metabolism.Additions of iron to cultures of the anaerobic Cl. sporogenes are followed by increases in metabolism of such intensity as to lead to the disintegration of the organisms (7).Compara- ble additions to cultures of baker's yeast are without effect (2).Aerobic cells appear to have a mechanism for holding the iron level within a toler- able range, presumably through the removal by oxidation and excretion of all but a minimal fraction of the catalytic iron intake.Impairment of this mechanism through a restriction of the oxygen intake may, in healthy
Regional Cerebral Blood Flow Abnormalities in Patients With Kawasaki Disease
Authors: Toshiyuki Hikita, Tatsuro Kaminaga, Suguru Wakita, Kaori Ogita, Hiroyuki Ikemoto, Yasushi Fujii, Hiroshi Oba, Yukishige Yanagawa
Journal: Clinical Nuclear Medicine (2011)

Kawasaki disease (KD) is an acute febrile disorder of unknown etiology. Brain single-photon emission computed tomography (SPECT) and magnetic resonance imaging (MRI) help in detecting regional cerebral blood flow abnormalities and brain damage. The usefulness of SPECT and MRI in patients with KD was evaluated.All 22 patients with KD underwent brain SPECT using Tc-99m-hexamethyl propylene amine oxime from 6 days to 3 years after onset, and 8 patients underwent brain MRI. Of the 22 patients, 4 had neurologic symptoms. Case 1 showed prolonged apnea; case 2, prolonged disturbance of consciousness; and cases 3 and 4 generalized tonic-clonic seizures. Initial brain SPECT showed localized hypoperfusion in 4 and 13 patients with and without neurologic symptoms, respectively.All patients with neurologic symptoms underwent follow-up SPECT; localized hypoperfusion was detected between 1- and 6-month follow-up in 3 of these patients. Six patients without neurologic symptoms underwent follow-up SPECT. Localized hypoperfusion was detected at approximately 1- to 11-month follow-up in 4 of these patients. Diffusion-weighted imaging revealed abnormal high-intensity areas in the corpus callosum in case 1. Case 2 showed a bilateral chronic subdural hematoma with decreased size and ischemic changes, and case 3 showed bilateral hippocampal atrophy and left hippocampal sclerosis.Because the occurrence of localized hypoperfusion is possibly not restricted to only the acute phase in KD, brain SPECT and MRI should also be performed in KD patients with neurologic symptoms.
Therapeutics of Infancy and Childhood.
Authors: A. Jacobi
Journal: JAMA (1896)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Hospital Employee Safety
Authors: Karen S. Kagey
Journal: JAMA (1972)

<h3>To the Editor.—</h3> The "Physician's Guide to the Occupational Safety and Health Act of 1970" (<b>219</b>:905, 1972) does not go into one area in which physicians will be meeting the Act; namely, involvement of hospitals as employers. Most current hospital safety attention has focused on the patient's safety. However, many nonpatient areas such as engineering, kitchen, laboratories, and previously overlooked portions of patient-related areas will now be coming under close scrutiny. We as physicians must recognize that development of hospital resources to these areas is vital and should not be construed as detracting from patient care. Indeed, solid application of basic environmental safety standards to<i>all</i>hospital areas will enhance patient safety and care.
Endoscopic Laser Therapy for Oesophageal Cancer
Authors: S.G. Bown
Journal: Endoscopy (1986)

Most oesophageal cancers are incurable by the time the diagnosis is made. Treatment is therefore often palliative, and endoscopic modalities cause considerably less general upset to the patient than surgery, radiotherapy or chemotherapy. Nd:YAG laser recanalisation of advanced obstructing cancers is safe and effective for exophytic tumours that are endoscopically accessible in over 80% of cases. The risk of perforation is less than half that associated with insertion of a perforation is less than half that associated with insertion of a prosthesis, although it is higher in patients who have previously been treated by radiotherapy. After laser treatment, half the patients are able to maintain adequate nutrition until the time of their death from disseminated disease. The other half get further dysphagia due to recurrent exophytic tumour or compression from extrinsic tumour. A few develop fibrous stricturing in the laser treated area. However, many of these recurrences can be treated again with the laser or by dilation with or without a prosthesis. The quality of swallowing is better after laser treatment, as any residual oesophageal muscle function in that area can be used (not possible with a prosthesis), although several treatment sessions are usually required. In the future, the precision of laser effects may make it possible to safely ablate early tumours in their entirety.
THE VASCULAK LESION IN VISCEROCUTANEOUS COLLAGENOSIS.
Authors: A. A. SHARP
Journal: British Journal of Dermatology (1957)

Journal Article THE VASCULAK LESION IN VISCEROCUTANEOUS COLLAGENOSIS. Get access A. A. SHARP A. A. SHARP Department of Pathology, Royal Victoria Infirmary, Newcastle‐upon‐Tyne Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 69, Issue 2, 1 February 1957, Pages 50–56, https://doi.org/10.1111/j.1365-2133.1957.tb13224.x Published: 01 February 1957
What is the optimal treatment strategy for chronic obstructive pulmonary disease exacerbations?
Authors: W. Willaert, M. Daenen, P. Bomans, G. Verleden, M. Decramer
Journal: European Respiratory Journal (2002)

The present study aims to determine whether treating chronic obstructive pulmonary disease (COPD) exacerbations with intravenous steroids and aerosol bronchodilators (group I) is superior to oral steroids and multiple dose inhaler (MDI) bronchodilators with a spacer (group II). Group I received 40 mg methylprednisolone·day<sup>−1</sup> intravenously with a decrease to 20 mg after 10 days and a further decrease of 4 mg·4 days<sup>−1</sup>. Aerosol therapy consisted of 10 mg salbutamol and 1 mg ipratropiumbromide·day<sup>−1</sup>. Group II received 32 mg methylprednisolone orally for 1 week followed by 24 mg·day<sup>−1</sup> for 4 days and a subsequent decrease of 4 mg·week<sup>−1</sup>. Duovent® MDI with a spacer was given at a dose of 1.6 mg fenoterol and 640 µg ipratropiumbromide·day<sup>−1</sup>. In group I (n=19) forced expiratory volume in one second (FEV<sub>1</sub>) rose from 0.82±0.46 to 0.91±0.47 L and average dyspnoea decreased from 6.0±1.9 to 4.1±2.6 within 10 days. The Chronic Respiratory Disease Index Questionnaire (CRQ) score increased from 78±24 to 90±24 points after 4 weeks. In group II (n=18) FEV<sub>1</sub> increased from 0.70±0.27 to 0.90±0.29 L, dyspnoea regressed from 6.2±2.4 to 2.7±2.6 and CRQ from 67±17 to 86±20. Both groups showed similar results in dropout rate, length of hospital stay and patient satisfaction. In conclusion, the two treatment strategies appear equally effective in treating chronic obstructive pulmonary disease exacerbations, although oral steroids and metered dose inhaler bronchodilators appear associated with a higher risk of hospital re-admission.
Associations between hepatitis C viremia and low serum triglyceride and cholesterol levels: A community-based study
Authors: Chia-Yen Dai, Wan-Long Chuang, Chi-Kung Ho, Ming-Yen Hsieh, Jee-Fu Huang, Li-Po Lee, Nai-Jen Hou, Zu-Yau Lin, Shinn-Cherng Chen, Ming-Yuh Hsieh, Liang-Yen Wang, Jun-Fa Tsai, Wen-Yu Chang, Ming-Lung Yu
Journal: Journal of Hepatology (2008)
Caring for Patients at the End of Life: Reflections after 12 Years of Practice
Authors: Richard A. Parker
Journal: Annals of Internal Medicine (2002)

Physicians have the privilege and authority to assist patients and their families at the end of life. Regardless of diagnosis, commonalities occur in the dying process, and palliative care benefits patients and families. This perspective chronicles my experience over 12 years caring for 95 patients at the end of life, illustrated in part with six vignettes. I describe interactions with families, discuss logistic issues around dying, examine the do-not-resuscitate issue, and highlight experiences with home visits. I also touch on how I communicate with the family after a death. I hope to express the significance of what I have learned while assisting patients and families at this critical juncture.
A Critical Analysis of Thirty Cases of Dislocation of the Shoulder Treated by Manipulation
Authors: J. L. Thomas
Journal: BMJ (1893)

BOWELS I'ylCE A YOn September 12th vomiting was less, and she was able to recline slightly; the opium mixture was nlow given every three hours.On September 13th sulphate of magnesia 30 grs. and tinet.opii in 20 were given every three hours, and the bowels acted t'ie same day.The circumference at the umbilicus was raduced to 33 inches.On September 14th the local dulness over the caecum was becomilng more defined, and oln September 16th the dulness in the flanks was disappearing and the patient able to lie down.Sulphate of magnesia, iron, and strychnine were ordered three times daily.The bowels were moved twice daily and nourishment was taken well.In the dulness over
Exempt MRI scanners from new EU rules, say campaigners
Authors: Rory Watson
Journal: BMJ (2007)

Medical specialists, patients' groups, and European parliamentarians launched a campaign last week to ensure that new EU health and safety legislation will not restrict the use of magnetic resonance imaging (MRI).

The Alliance for MRI fears that new Europe-wide measures, which are designed to protect employees from short term exposure to electromagnetic fields, will inadvertently make it harder to use equipment to diagnose and treat illnesses from cancer and heart attacks to strokes and brain tumours.

The legislation will limit the time that operators may spend near MRI machines when in use. The alliance warns that this will make it more difficult …
ADAM10 Missense Mutations Potentiate β-Amyloid Accumulation by Impairing Prodomain Chaperone Function
Authors: Jaehong Suh, Se Hoon Choi, Donna M. Romano, Moira A. Gannon, Andrea N. Lesinski, Doo Yeon Kim, Rudolph E. Tanzi
Journal: Neuron (2013)
Homeodomain-Interacting Protein Kinase 2 Is the Ionizing Radiation–Activated p53 Serine 46 Kinase and Is Regulated by ATM
Authors: Ilka Dauth, Jana Krüger, Thomas G. Hofmann
Journal: Cancer Research (2007)

Abstract Phosphorylation of p53 at Ser46 is important to activate the apoptotic program. The protein kinase that phosphorylates p53 Ser46 in response to DNA double-strand breaks is currently unknown. The identification of this kinase is of particular interest because it may contribute to the outcome of cancer therapy. Here, we report that ionizing radiation (IR) provokes homeodomain-interacting protein kinase 2 (HIPK2) accumulation, activation, and complex formation with p53. IR-induced HIPK2 up-regulation strictly correlates with p53 Ser46 phosphorylation. Down-regulation of HIPK2 by RNA interference specifically inhibits IR-induced phosphorylation of p53 at Ser46. Moreover, we show that HIPK2 activation after IR is regulated by the DNA damage checkpoint kinase ataxia telangiectasia mutated (ATM). Cells from ataxia telangiectasia patients show defects in HIPK2 accumulation. Concordantly, IR-induced HIPK2 accumulation is blocked by pharmacologic inhibition of ATM. Furthermore, ATM down-regulation by RNA interference inhibited IR-induced HIPK2 accumulation, whereas checkpoint kinase 2 deficiency showed no effect. Taken together, our findings indicate that HIPK2 is the IR-activated p53 Ser46 kinase and is regulated by ATM. [Cancer Res 2007;67(5):2274–9]