A STUDY OF THE HEREDITARY NATURE OF GOUT; A REPORT OF TWO FAMILIES
Authors: C. J. Smyth, R. H. Freyberg
Journal: Annals of Internal Medicine (1942)

Article1 January 1942A STUDY OF THE HEREDITARY NATURE OF GOUT; A REPORT OF TWO FAMILIESC. J. SMYTH, M.D., R. H. FREYBERG, M.D.C. J. SMYTH, M.D.Search for more papers by this author, R. H. FREYBERG, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-16-1-46 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptStimulated by the observation of gout in several members of one family we have made a systematic study of all of the immediate relatives of two gouty individuals in order to determine the importance of heredity as a factor in the etiology of this disease. In the vast amount of literature on the subject of gout and uric acid, reports ofprovedcases of gout in near relatives of patients in whom the diagnosis of gout has been established are sufficiently rare to make this study valuable. As far as can be determined, this is the first systematic investigation of...Bibliography1. SCUDAMORE C: A treatise on the nature and cure of gout and rheumatism, 1819, Edward Earle, Philadelphia. Google Scholar2. GARROD AE: The inborn factors in disease, 1931, Oxford Press, New York. CrossrefGoogle Scholar3. GARROD AB: The nature and treatment of gout and rheumatic gout, 1859, Walton and Maberly, London. Google Scholar4. ALLBUTT TC: Gout, in The Oxford Medicine, 1936, IV, pt. 1, chap. IV, 82, Oxford University Press, New York. Google Scholar5. WEIL MP: L'hérédité des goutteux, Presse méd., 1934, xlii, 701-702. Google Scholar6. PRATT JH: Gout, in Nelson Loose-Leaf Med., 1923, III, chap. 3, 37, Thomas Nelson and Sons, New York. Google Scholar7. FOLINLYMAN OH: On the influence of phenylquinolin carbonic acid (atophan) on uric acid elimination, Jr. Pharmacol. and Exper. Therap., 1913, iv, 539-546. Google Scholar8. FOLINDENIS OW: The diagnostic value of uric acid determination in blood, Arch. Int. Med., 1915, xvi, 33-37. CrossrefGoogle Scholar9. JACOBSON BM: Uric acid in serum of gouty and non-gouty individuals: its determination by Folin's recent method and its significance in diagnosis of gout, ANN. INT. MED., 1938, xi, 1277-1295. LinkGoogle Scholar10. FOLIN O: Standardized methods for determination of uric acid in unlaked blood and in urine, Jr. Biol. Chem., 1933, ci, 111-125. CrossrefGoogle Scholar11. DE GALANTHA E: Technic for preservation and microscopic demonstration of nodules in gout, Am. Jr. Clin. Path., 1935, v, 165-166. CrossrefGoogle Scholar12. LOCKIEHUBBARD LMRS: Gout: changes in symptoms and purine metabolism produced by high fat diets in 4 gouty patients, Jr. Am. Med. Assoc., 1935, civ, 2072-2075 CrossrefGoogle Scholar13. BAURFISCHERLENZ EEF: Human Heredity, translated by Eden and Ceder Paul from the Third German edition, 1931, The Macmillan Company, New York. CrossrefGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Ann Arbor, Michigan*Received for publication April 22, 1940.From the Rackham Arthritis Research Unit, the Medical School, University of Michigan, Ann Arbor.The Rackham Arthritis Research Unit is supported by the Horace H. Rackham School of Graduate Studies, of the University of Michigan. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byGouty arthritis masquerading as rheumatoid arthritis or vice versaSpezielle ProblemeClinical experiencesDie Lokalisation der Gicht im H�ftgelenkHEREDITY IN PRIMARY GOUTGenetic factors in diseases of connective tissueHeredity in Gout and HyperuricemiaTHE INHERITANCE OF SPONDYLITIS RHIZOMELIQUE (ANKYLOSING SPONDYLITIS) IN THE K. FAMILY*HERMAN H. RIECKER, M.D., F.A.C.P., JAMES V. NEEL, Ph.D., M.D., AVERY TEST, Ph.D.Review of Gout, 1939-1946 1 January 1942Volume 16, Issue 1Page: 46-56KeywordsArthritisEtiologyGoutGraduate medical educationHeredityUric acid ePublished: 1 December 2008 Issue Published: 1 January 1942 PDF downloadLoading ...