tbuckley/cabot-search huggingface dataset:
Abstract 5025: Transition to Menopause and Preclinical Atherosclerosis in Women: A Report from the Los Angeles Atherosclerosis Study (LAAS)
Authors: B Delia Johnson, Kathleen Dwyer, Maura Paul-Labrador, Frank Stanczyk, Vera Bittner, Sarah L Berga, Glenn D Braunstein, Ricardo Azziz, YuChing Yang, Philip Bretsky, C Noel Bairey Merz
Journal: Circulation (2008)

While the relation between the onset of menopause and accelerated cardiovascular risk has been extensively studied, little information exists on the relationship of the menopausal transition and the development of preclinical atherosclerosis in women. We hypothesized that transition to menopause would be associated with a higher rate of progression of preclinical atherosclerosis. Methods: We evaluated 203 women (131 postmenopausal, 20 perimenopausal, and 52 premenopausal at entry) undergoing carotid intimal-media thickness (cIMT) measurement in the LAAS study, a prospective cohort study that included women aged 45– 60 years at entry without diagnosed cardiovascular disease who underwent three measurements (baseline, 1.5 and 3 year followup). cIMT was measured bilaterally in two body positions (lateral and supine), and average thickness over a 1 cm segment of the distal wall 25 mm proximal to the bulb was measured using automated edge-tracking software. Results: The mean age was 52±4 years, mean body mass index was 27.2±5.8, and 49% were non-white. At entry, 53% had hypertension, 3% diabetes, 16% were current smokers. Age-adjusted cIMT progression rate was similar among pre-, peri- and postmenopausal women (9±15 μ/yr) at entry, and similar among women who remained premenopausal (n=21) compared to those that transitioned to menopause (n=51) and to those who remained postmenopausal (n=131) during the observation period. Of the 51 transitioning women, age was not related to rate of cIMT progression. However, the rapidity of menopausal transition was related to the rate of IMT progression: women transitioning from pre to postmenopause within the 3 year period had a higher rate of cIMT progression compared to women with a slower transition (progressing from pre- to perimenopause, or from peri- to postmenopause, p=0.03). Additional adjustment of these results for systolic blood pressure and BMI did not alter the results. Conclusions: Among women undergoing repeated cIMT measurement in the LAAS, a more rapid menopausal transition (from pre- to postmenopause within 3 years) was associated with a higher rate of preclinical atherosclerosis progression; alternatively, menopausal status itself did not appear to be associated with rate of progression.
Intraprocedural Thrombotic Events During Percutaneous Coronary Intervention in Patients With Non–ST-Segment Elevation Acute Coronary Syndromes Are Associated With Adverse Outcomes
Authors: Margaret B. McEntegart, Ajay J. Kirtane, Ecaterina Cristea, Sorin Brener, Roxana Mehran, Martin Fahy, Jeffrey W. Moses, Gregg W. Stone
Journal: Journal of the American College of Cardiology (2012)
Use of neuroleptic-induced extrapyramidal symptoms to predict future vulnerability to side effects
Authors: G A Keepers, D E Casey
Journal: American Journal of Psychiatry (1991)

Susceptibility to neuroleptic-induced extrapyramidal syndromes varies widely, even within age and sex subgroups. Individual vulnerability to extrapyramidal syndromes has been assumed to explain this, but the utility of past history for predicting future occurrence of extrapyramidal syndromes has not been studied extensively. This investigation was undertaken to determine whether patients' previous histories of extrapyramidal syndromes predict future episodes of extrapyramidal syndromes and to compare the importance of this predictive factor with patient age, sex, neuroleptic dose, and anticholinergic dose as predictors of extrapyramidal syndromes.The charts of 62 schizophrenic patients with multiple neuroleptic treatment episodes were reviewed. Extrapyramidal syndromes, neuroleptic drug doses, and anticholinergic drug doses during the first 21 days of each treatment episode were recorded.Previous extrapyramidal syndromes correctly predicted extrapyramidal syndromes in subsequent treatments for 84% of the patients. Variations in neuroleptic potency, neuroleptic dose, and anticholinergic dose partially explained incorrect predictions.These results support the hypothesis that patients with a history of extrapyramidal syndromes are at greater risk for future extrapyramidal syndromes. If confirmed, these results strongly support individual susceptibility as a major predictor of extrapyramidal syndromes and indicate that prophylaxis of extrapyramidal syndromes should be considered for patients who have previously suffered extrapyramidal syndromes from similarly prescribed neuroleptic therapy.
Abstract 14303: Pharmacologic suppression of Hepcidin by Inhibition of Bone Morphogenetic Protein Signaling Reduces Foam Cell Formation and Atherosclerosis
Authors: Omar Saeed, Fumiyuki Otsuka, Rohini Polavarapu, Vinit Karmali, Daiana Weiss, Talina Davis, Brad Rostad, Lila Adams, W R Taylor, Charles C Hong, Frank Kolodgie, Renu Virmani, Aloke V Finn
Journal: Circulation (2011)

Introduction: Atherosclerosis is a major etiology of cardiovascular disease. The atheroma is comprised of macrophages that ingest lipids to transform into foam cells. Foam cell formation is reduced...
Abstract 14135: Differential Response of Arterial Healing Following Second- versus First-Generation Drug-Eluting Stents in Humans - A Pathologic Study
Authors: Fumiyuki Otsuka, Masataka Nakano, Marc Vorpahl, Saami K Yazdani, Elena Ladich, Aloke V Finn, Frank D Kolodgie, Renu Virmani
Journal: Circulation (2011)

Background: Previous pathologic studies in 1st-generation drug-eluting stents (1st-gen DES; sirolimus- [SES] and paclitaxel- [PES]) have demonstrated that delayed arterial healing is accompanied by...
Abstract 14948: Clinical Characteristics of Idiopathic Ventricular Fibrillation with Early Repolarization and Response of Early Repolarization to Sodium Channel Blocker: Comparison to Brugada Syndrome with Ventricular Fibrillation.
Authors: Hiro Kawata, Takashi Noda, Hisaki Makimoto, Atsushi Doi, Teruki Yokoyama, Yuko Yamada, Hideo Okamura, Kazuhiro Satomi, Naohiko Aihara, Shiro Kamakura, Wataru Shimizu
Journal: Circulation (2010)

Background: Recent studies have shown a high incidence of early repolarization (J-point elevation) in inferolateral leads in patients with idiopathic ventricular fibrillation (IVF). Brugada syndrome (BS) is also characterized by J-point and ST elevation in right precordial leads and VF. However little is known about similarities and differences between IVF with early repolarization (Early Repolarization Syndrome: ERS) and BS. Methods: Fourteen patients of ERS and twenty-one patients of BS with documented VF were included into this study. Early repolarization was defined as an elevation of the J-point (QRS-ST junction) of at least 0.1mv from baseline in inferior or lateral leads. All patients experienced VF which was confirmed in electrocardiography (ECG) or monitor ECG and follow up data was collected from implantable cardioverter defibrillator (ICD). To distinguish precisely between ERS and BS, provocative tests with sodium-channel blockers were performed in all ERS and BS patients. Results: In ERS group...
Onset of Gilles de la Tourette's syndrome before 1 year of age
Authors: L Burd, J Kerbeshian
Journal: American Journal of Psychiatry (1987)

The authors report on three patients in North Dakota with an apparent onset of Gilles de la Tourette's syndrome before 1 year of age. Infantile onset may occur in 4.1% of the child patients with Tourette's disorder in that state. It is suggested that the diagnostic criteria for Tourette's disorder be revised to include patients who develop the illness before they are 1 year old.
More on the Bristol affair
Authors: P. M Dunn, G. M Stirrat, S. Bolsin, M. Shortis, E. Winkler, M. Cummings
Journal: BMJ (1999)

Editor—Bolsin’s audit of the Bristol surgeons’ work in 1990-2 was first seen by them in May 1995 after it had been widely reported in the media. It was then found to be flawed.1 Bolsin’s article also contains several errors,2 to some of which I have already responded.1,3 I was surprised, for example, that he still denied that his audit had been secret, for he had referred to it in those terms at the General Medical Council’s inquiry (day 7, 23 October, p 102 of transcript). I note too that he now claims that his audit started in 19912; when asked at the inquiry whether his data could have been used by Private Eye in April 1992,4 he categorically denied starting data collection and analysis before the late summer of that year (see the inquiry’s transcripts for day 6 (22 October, pp 81-6) and day 7 (pp 16-20, 24).5

It is difficult to understand Bolsin’s motivation for continuing to attack the Bristol surgeons after the GMC’s harsh determination in June 1998. Until May 1995 he was for seven years a vital member of the surgical team. Anaesthetists share responsibility during cardiac bypass operations for keeping patients alive and their brains well perfused. Has Bolsin ever considered whether he may himself have contributed to the disappointing outcome among 4% of the surgeons’ cases (see day 7 of inquiry’s transcripts, p 42).5

Bolsin has been hailed as a “courageous whistleblower.” 4 But his unilateral approach to the Department of Health in January 1995 had no positive influence on paediatric cardiac surgery in Bristol. The highly effective improvements to the service, first requested by the surgical team in 1989, had been agreed by the trust several months earlier and were already being implemented.1

There were, however, several serious negative outcomes. Bolsin’s kind of whistleblowing has been sanctioned and even encouraged. Morale and trust among colleagues have been damaged. The public’s confidence in the profession has been undermined. The willingness of doctors to perform high risk interventions to save life, or to undertake honest and open clinical audit, must have been eroded. Critics have been provided with ammunition to attack the profession and hasten changes in regulation, some of which may not be in the best interests of the service. Worst of all, the breach in confidentiality that resulted has led to the opening of emotional wounds among bereaved and grieving parents. These, then, are some of the legacies of this sorry affair to which Bolsin himself has made such an important contribution.
Abstract 10885: Nox4 Nadph Oxidase Protects Against Load-Induced Cardiac Remodeling by Enhancing Myocardial Angiogenesis
Authors: Min Zhang, Alison C Brewer, Katrin Schroder, Celio X Santos, Minshu Wang, Narayana Anilkumar, Bin Yu, Xuebin Dong, Simon J Walker, Ralf P Brandes, Ajay M Shah
Journal: Circulation (2010)

Background: Reactive oxygen species (ROS) production is involved in the development of cardiac remodeling. NADPH oxidases are major ROS sources and cardiomyocytes express both Nox2 and Nox4. Nox2 i...
Abstract 4277: Acute Type A Intramural Hematoma: Analysis of Current Management Strategy
Authors: Anthony L Estrera, Charles C Miller, Taek-Yeon Lee, Paula DeRango, Ali Azizzadeh, Jon-Cecil Walkes, Hazim J Safi
Journal: Circulation (2008)

Introduction: Management of Acute Type A intramural hematoma (IMH) remains controversial varying from immediate surgery to medical management only. Conversion to classic dissection remains a primar...
Phase II Clinical and Correlative Study Of Carfilzomib, Lenalidomide, and Dexamethasone Followed By Lenalidomide Extended Dosing (CRD-R) Induces High Rates Of MRD Negativity In Newly Diagnosed Multiple Myeloma (MM) Patients
Authors: Neha Korde, Adriana Zingone, Mary L Kwok, Elisabet E. Manasanch, Manisha Bhutani, Nishant Tageja, Dickran Kazandjian, Sham Mailankody, Rene Costello, Yong Zhang, Debra Burton, George Carter, Peter Wu, Marcia Mulquin, Diamond Zuchlinski, Irina Maric, Katherine R Calvo, Raul C. Braylan, Mark Roschewski, Constance Yuan, Maryalice Stetler-Stevenson, Diane C Arthur, Liza Lindenberg, Karen Kurdziel, Pete Choyke, Seth M. Steinberg, Ola Landgren
Journal: Blood (2013)
Abstract 82: External Cardiac Defibrillation during Wet Surface Cooling in Pigs
Authors: Alexandra Schratter, Wolfgang Weihs, Michael Holzer, Andreas Janata, Wilhelm Behringer, Martin Frossard, Keywan Bayegan, Udo M Losert, Anton N Laggner, William J Ohley, Cathy Klock-Frezot, Robert B Schock, Fritz Sterz
Journal: Circulation (2006)

Objective Mild hypothermia can be induced by direct immersion of a patient in ice water, however this situation presents a potentially challenging setting for defibrillation. Direct measurements of...
STUDIES ON HUMAN CAPILLARIES
Authors: J. Hamilton Crawford, H. Rosenberger
Journal: Journal of Clinical Investigation (1927)

In previous studies of the capillary circulation it was found that changes in the calibre of the capillaries took place continuously, both in health when the rhythm of the heart is regular, and in auricular fibrillation.The extent of these changes appeared to depend on the state of circulatory compensation and was independent of the rate or regularity of the pulse.Similar variations were observed in advanced decompensation both in cases of regular and of irregular rhythm.The present investigation was undertaken to study the changes which take place in heart disease with regular rhythm from the early to the late stages of the disease.Weiss (1) found in his studies of the capil-
Abstract 350: Toll-like Receptor 2 Activation, Especially In Circulating Leukocytes, Mediates Myocardial Ischemia/Reperfusion Injury In Mice
Authors: Fatih Arslan, Gerard Pasterkamp, Leo Timmers, Ben van Middelaar, Pieter A Doevendans, Dominique P de Kleijn
Journal: Circulation (2008)

OBJECTIVES. Myocardial ischemia/reperfusion (MI/R) injury is characterized by an inflammatory response through NF-κB, increase of infarct size and worsening of cardiac function. Toll-like receptors (TLRs) are part of innate immunity and initiate the same inflammatory reaction. Here we studied in vivo to what extent TLR2 is involved in myocardial damage and what the relative contribution is of TLR2 expression in parenchymal cells and leukocytes to myocardial damage during MI/R in mice. METHODS. C57Bl6J mice underwent 30 minutes ischemia - 24 hours of reperfusion. Four experimental groups were studied: TLR2 knock-out (TLR2 KO) mice (n=10), saline treated wild-type (WT) mice (n=10), generated chimeric WT mice with TLR2 KO bone marrow (BLOOD KO; n=7) and chimeric TLR2 KO mice with WT hematopoietic cells (ORGAN KO; n=7). Saline was administered via the tail vein 5 minutes prior to reperfusion. After 24 hours, the LCA was ligated again at the level marked by the suture left in place. Mice were terminated and infarct size (IS) was measured as a percentage of the area at risk (AAR) using 4% Evans’ blue dye injection in the aortic root and triphenyltetrazolium chloride (TTC) staining (fig. 1). Data are presented as Mean±SEM. RESULTS. The AAR as percentage of the left ventricle was similar between groups: TLR2 KO 41%, saline 41%, Blood KO 41%, Organ KO 42%. Saline treatment resulted in 34.5%±3.3 of infarction, whereas in TLR2 KO mice infarct size decreased to 23.0%±2.9 (p=0.029 vs. saline). Infarct size in BLOOD KO mice was 22.9%±2.7 (p=0.024 vs. saline), while ORGAN KO mice had 33.9%±3.2 (p=0.998 vs. saline) of infarction within the area at risk (fig. 2). CONCLUSION. TLR2 deficiency significantly reduces infarct size with ~33% compared to saline treatment in mice after 30 minutes of ischemia and 24 hours of reperfusion. We show for the first time that TLR2 expression in circulating leukocytes plays an important role in infarction after MI/R injury. Systemic inhibition of TLR2 may be a potential therapeutic target in the treatment of patients with acute myocardial infarction.
Subdural Haematoma Due to Meningeal Metastasis
Authors: J. A. M. Frederiks
Journal: Neuro-Oncology (1980)

Most intracranial metastases are in the cerebrum and the cerebellum. The localization of metastatic malignant disease in the dura mater is very rare (1).Recently we observed a most unusual case of subdural haematoma.Firstly because it recurred, secondly because it originated from metastatic lung carcinoma and thirdly because the haematoma was antemortem the only clinical manifestation of malignant disease of the lung.
Abstract 13168: Abnormal Circumferential Strain Is Present in Young Duchenne Muscular Dystrophy Patients
Authors: Thomas D Ryan, Michelle A Grenier, Michael D Taylor, Linda H Cripe, Jesse Pratt, Eileen C King, Wojciech Mazur, John L Jefferies, Dudley W Benson, Kan N Hor
Journal: Circulation (2011)

Background Advances in management of Duchenne muscular dystrophy (DMD) have improved such that DMD-associated cardiac disease has become the leading cause of death. Cardiac function as measured by standard transthoracic echocardiogram (TTE) methods, e.g. fractional shortening (FS), rarely detects global dysfunction during the first decade. In the current study we used TTE to assess strain (e), both segmentally and globally, in young DMD patients. Methods TTE from DMD patients ≤8 years (n=63) recorded during 2009-2010 were compared to TTE of an age-matched control group with no cardiovascular disease (n=61). Feature tracking analysis software (Image Arena, TomTec, Germany) was used to measure global circumferential strain (ecc) and segmental ecc based on a modified AHA/ASE 16-segment model. Results While there were no differences in FS between groups, the global ecc was lower in DMD patients (-21.7±3.8 vs. -19.8±4.2, p=0.01; normal vs. DMD). Further, segmental ecc was lower in the anterior segment (-23.0±6...
The PI3K Delta Inhibitor Idelalisib Interferes With Pre-B Cell Receptor Signaling In Acute Lymphoblastic Leukemia (ALL): A New Therapeutic Concept
Authors: Nathalie Y. Rosin, Ekaterina Kim, Stefan Koehrer, Zhiqiang Wang, Susan O'Brien, William G. Wierda, Deborah A. Thomas, Zeev Estrov, Hagop M. Kantarjian, Brian Lannutti, Richard E. Davis, Jan A. Burger
Journal: Blood (2013)
The movement toward integrating the psychotherapies: an overview
Authors: B D Beitman, M R Goldfried, J C Norcross
Journal: American Journal of Psychiatry (1989)

There is a growing tendency among psychotherapists to ignore the ideological barriers dividing schools of psychotherapy and to define what is common among them and what is useful in each of them. After a brief introduction the authors provide a short glossary of terms often associated with psychotherapy integration. They then characterize integrative-eclectic therapists, describe the forces fostering their emergence, and outline recurrent themes of the movement and points of contention within it. The authors hope to encourage clinical thinking about the less ideological approaches to psychotherapy and to advance the integrative movement, which is likely to influence psychotherapeutic practice for decades to come.
Abstract 2601: Staged Left Ventricular Recruitment in Patients with Hypoplastic Left Heart Disease and Borderline Left Ventricle
Authors: Sitaram M Emani, Wayne Tworetzky, Doff B McElhinney, Brian Schroeder, David Zurakowski, Emile Bacha, Frank A Pigula, Gerald R Marx, Pedro J del Nido
Journal: Circulation (2008)

Although hypoplastic left heart (LH) disease occurs as a spectrum, the initial management in neonates with hypoplastic LH syndrome and a borderline left ventricle (LV) is dichotomous: single ventricle palliation (SVP) or biventricular (BiV) repair. Once SVP is pursued, rarely are attempts made to salvage the LH or achieve subsequent BiV conversion. Staged LV recruitment may be achieved in selected patients following SVP by a surgical strategy consisting of relief of inflow and outflow tract obstructions, resection of endocardial fibroelastosis (EFE), and promotion of flow through the LV. All patients with hypoplastic LH and borderline LV (LV end diastolic volume [LVEDV] z scores between −5 and −0.5) who underwent stage 1 procedure between 1995 and 2007 were retrospectively analyzed. Patients with ventricular septal defects and valvular atresia were excluded. Those who underwent LV recruitment (Group 1, n=27) were compared to those who did not (Group 2, n=30). LV recruitment consisted of one or more procedures for EFE resection (27/27), mitral (MV) valvuloplasty (16/27), aortic (AoV) valvulo-plasty (21/27), atrial septal defect restriction (13/27), and augmentation of pulmonary blood flow (12/27). Predictors of increase in LVEDV were determined by multivariable analysis. Mean initial z scores for LVEDV, AoV, and MV for the entire cohort were −2.8 ± 1.2, −2.9 ± 1.0, and −2.0 ± 1.3 respectively, with no significant differences between groups. Stage 1 mortality was 2/27 in Group 1 and 2/30 in Group 2. LVEDV, AoV, and MV z scores increased significantly over time in Group 1, whereas they declined in Group 2 (slope of LVEDV z score regression = 0.76/yr vs. −0.06/yr, P &lt;0.001), with restriction of the atrial septum at any stage being the strongest independent predictor of increase in LVEDV ( P &lt;0.001). To date, BiV conversion has been achieved in 5/27 Group 1 patients and none in Group 2 ( P =0.015). In patients with borderline LH disease who undergo a stage I procedure during the neonatal period, it is possible to increase LH dimensions using a strategy of AoV and MV valvuloplasty, EFE resection, and modulation of LV filling. In a subset of patients, this strategy has allowed establishment of biventricular circulation.
Abstract 8854: Increased Carotid Intima-Media Thickness and Arterial Stiffness are Associated with Lone Atrial Fibrillation
Authors: Lin Y Chen, Stefanie Schussler, Lingli Gong, David C Foo, Raymond C Wong, Swee-Chong Seow, Lieng H Ling
Journal: Circulation (2011)

Background Increased carotid intima-media thickness (cIMT) and pulse pressure are associated with common acquired atrial fibrillation (AF). It is unknown whether cIMT and indexes of arterial stiffness are associated with lone AF-onset of AF in patients &lt;60 years in the absence of risk factors for AF. We sought to determine whether cIMT, arterial compliance (AC), carotid-femoral pulse wave velocity (CFPWV), and β stiffness index are associated with lone AF. Methods Consecutive patients referred to the arrhythmia clinic for lone AF (onset &lt;60 years) in the absence of hypertension, diabetes, and structural heart disease were included in the study. Patients &lt;60 years seen in the general cardiology clinic without AF, hypertension, diabetes, and structural heart disease were included as controls. cIMT was measured by high resolution B-mode ultrasound. CFPWV was measured by applanation tonometry. AC and β stiffness index were measured using direct radiofrequency tracking of carotid artery pulsatility using Aloka eTracking software. All measurements were obtained during sinus rhythm. Multivariable logistic regression was used to assess association between lone AF and these exposures (modeled as quartiles): cIMT, AC, CFPWV, and β stiffness index. Results We enrolled 133 lone AF cases (all variables presented as mean ± standard deviation - age at onset: 44.9 ± 10.6 years, cIMT: 0.68 ± 0.16 mm, AC: 0.73 ± 0.31 mm 2 /Kpa, CFPWV: 7.8 ± 1.8 m/s, β stiffness index: 10.9 ± 4.4) and 171 controls (age at enrollment: 46.7 ± 9.4years, cIMT: 0.61 ± 0.13 mm, AC: 0.84 ± 0.30 mm 2 /Kpa, CFPWV: 7.1 ± 1.3 m/s, β stiffness index: 8.6 ± 3.1). In multivariable logistic regression analyses, cIMT (OR, 1.6 per quartile increment; 95% CI, 1.2 to 2.1; p=0.002), AC (OR, 0.7 per quartile increment; 95% CI, 0.5 to 0.9; p=0.004), CFPWV (OR, 1.4 per quartile increment; 95% CI, 1.1 to 1.8; p=0.02), and β stiffness index (OR, 1.7 per quartile increment; 95% CI, 1.3 to 2.4; p=0.0005) were found to be associated with lone AF after adjusting for age, gender, and left atrial volume index. Conclusions Increased cIMT and arterial stiffness are associated with lone AF. Lone AF is not only an ‘electrical disease’. Morphological and functional changes in the arteries may increase risk of lone AF, as in common acquired AF.