ALBRIGHT'S SYNDROME
Authors: R E HIBBS, H P RUSH
Journal: Annals of Internal Medicine (1952)

Case Reports1 September 1952ALBRIGHT'S SYNDROMERALPH E. HIBBS, M.D., F.A.C.P., HOMER P. RUSH, M.D., F.A.C.P.RALPH E. HIBBS, M.D., F.A.C.P.Search for more papers by this author, HOMER P. RUSH, M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-37-3-587 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptAlbright's syndrome1is characterized by brown pigmentation of the skin, a cystic disease of the bone and precocious puberty in females. It is a rare disease—less than 50 cases of the complete syndrome have been reported to date. Other terms used to describe this disease include polyostotic fibrous dysplasia, brown spot syndrome and osteitis fibrosa disseminata. Its importance lies in the recognition of the bone lesions and their differentiation from those of hyperparathyroidism and other cystic diseases of the bone. If Albright's syndrome is present, an operation on the parathyroids can be avoided, since these glands are not involved in...Bibliography1. AlbrightButlerHamptonSmith FAMAOP: Syndrome characterized by osteitis fibrosa disseminata, areas of pigmentation, and endocrine dysfunction with precocious puberty in females, New England J. Med. 216: 17, 1937. CrossrefGoogle Scholar2. Albright F: Personal communication. These X-rays were reviewed by Dr. Albright, who thought they undoubtedly represented polyostotic fibrous dysplasia. Google Scholar3. DockertyGhormleyKennedyPugh MBRKRLDG: Polyostotic fibrous dysplasia, Arch. Int. Med. 75: 357 (June) 1945. CrossrefGoogle Scholar4. LichtensteinJaffee LHL: Fibrous dysplasia of bone: a condition affecting one, several or many bones, the graver cases of which may present abnormal pigmentation of skin, premature sexual development, hyperthyroidism or still other extraskeletal abnormalities, Arch. Path. 33: 777-816 (June) 1942. Google Scholar5. Garlock JH: Differential diagnosis of hyperparathyroidism, with special reference to polyostotic fibrous dysplasia, Ann. Surg. 108: 347-361, 1938. CrossrefMedlineGoogle Scholar6. AlbrightScovilleSulkowitch FBHW: Syndrome characterized by osteitis fibrosa disseminata, areas of pigmentation, and a gonadal dysfunction, Endocrinology 22: 411-421 (April) 1938. CrossrefGoogle Scholar7. Helfet AJ: A new conception of parathyroid function and its clinical application: a preliminary report on the results of treatment of general fibrocystic and allied bone disease and of rheumatoid arthritis by aluminum acetate, Brit. J. Surg. 27: 651-677 (April) 1940. CrossrefGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: *Received for publication December 27, 1950.From the Department of Medicine, University of Oregon Medical School. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byMcCune-Albright Syndrome and Disorders Due to Activating Mutations of GNAS1Gsα Mutations in Fibrous Dysplasia and McCune-Albright SyndromeMcCune-Albright SyndromeOther Skeletal Diseases Resulting from G Protein DefectsEndocrine Manifestations of Stimulatory G Protein α-Subunit Mutations and the Role of Genomic ImprintingFibrous Dysplasia and the McCune-Albright SyndromeMonozygotic twins discordant for the major signs of McCune-Albright syndromeThe McCune-Albright SyndromeNeurofibromatosis and Albright's SyndromePortraits and BiographiesA probable monogenic form of polyostotic fibrous dysplasiaTumor-like LesionsGeneralized melanoses and nonmelanotic pigmentations of the head and neckDie OsteodysplasienCardiac output and Albright's syndromeUNILATERAL DYSPLASIA OF BONE IN AN ELDERLY WOMAN 1 September 1952Volume 37, Issue 3Page: 587-593KeywordsBoneDysplasiaHyperparathyroidismLesionsMetastasisParathyroidPubertySkin diseases ePublished: 1 December 2008 Issue Published: 1 September 1952 PDF downloadLoading ...