INTERMITTENT DOSAGE SCHEDULES OF STREPTOMYCIN WITH RESULTANT PROLONGED SENSITIVITY OF M. TUBERCULOSIS
Authors: Vern F. Deyke, Myron W. Fisher, Lynn A. James, Leroy J. Sides
Journal: Annals of Internal Medicine (1949)

Article1 March 1949INTERMITTENT DOSAGE SCHEDULES OF STREPTOMYCIN WITH RESULTANT PROLONGED SENSITIVITY OF M. TUBERCULOSISVERN F. DEYKE, MYRON W. FISHER, LYNN A. JAMES, LEROY J. SIDESVERN F. DEYKESearch for more papers by this author, MYRON W. FISHERSearch for more papers by this author, LYNN A. JAMESSearch for more papers by this author, LEROY J. SIDESSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-30-3-619 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptCurrent streptomycin treatment regimens for pulmonary tuberculosis have been dictated largely by streptomycin toxicity and by development of bacterial resistance to this antibiotic. Since the initial utilization of streptomycin as an adjunct to the treatment of tuberculosis,9, 8the general trends to minimize or eliminate these obstacles have been toward reductions in daily dosage, frequency of administration, and duration of treatment. These trends have effected a reduction of toxicity; however, the latter trend has been utilized to avoid rather than to solve the paramount obstacle of prolonged effective treatment, namely the development of bacterial resistance. This, in our opinion, has...Bibliography1. BUGGSBRONSTEINHIRSHFIELDPILLING CWBJWMA: The in vitro action of streptomycin on bacteria, Jr. Am. Med. Assoc., 1946, cxxx, 64-67. CrossrefGoogle Scholar2. Editorial, Comments on streptomycin, Tuberculology, 1947, ix, 71. Google Scholar3. CORPERCOHN HJML: Personal communication, later reported as: The remote sustained threshold therapeutic action of streptomycin in tuberculosis, Science, 1947, cvi, 446-447. CrossrefGoogle Scholar4. 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Biol. and Med., 1946, lxiii, 131-134. CrossrefGoogle Scholar20. YOUMANSWILLISTONFELDMANHINSHAW GPEHWHHC: Increase in resistance of tubercle bacilli to streptomycin: A preliminary report, Proc. Staff Meet. Mayo Clin., 1946, xxi, 126-127. Google Scholar21. BERNSTEIND'ESOPOSTEENKEN SNDW: Streptomycin resistant tubercle bacilli. Incidence in patients treated with streptomycin, Am. Rev. Tuberc., 1948, lviii, 344-352. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: *Received for publication September 4, 1948.(Preliminary report presented to the Fifth Streptomycin Conference, Chicago, Illinois, April 15 to 18, 1948.)From the Streptomycin Research Project, Tuberculosis Branch, Medical Service, Fitzsimons General Hospital, C. B. Kendall, Col., M.C., Chief of Service, C. W. Tempel, Col., M.C., Chief of Branch; and from the Laboratory Service, Fitzsimons General Hospital, H. W. Mahon, Col., M.C., Chief of Service. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byTuberculous pericarditis∗Emergence of Antibiotic-Resistant BacteriaCRITERIA FOR THE CLINICAL EVALUATION OF ANTITUBERCULOUS AGENTSSelecting the Streptomycin Regimen for Patients with Pulmonary Tuberculosis with Special Reference to the Intermittent Dosage ScheduleRecent advances in streptomycin therapy 1 March 1949Volume 30, Issue 3Page: 619-634KeywordsAntibiotic resistanceChartsMedical servicesResearch laboratoriesStreptomycinToxicity ePublished: 1 December 2008 Issue Published: 1 March 1949 PDF downloadLoading ...