Treatment of Theophylline Neurotoxicity with Resin Hemoperfusion
Authors: CARL LAWYER
Journal: Annals of Internal Medicine (1978)

Brief Reports1 April 1978Treatment of Theophylline Neurotoxicity with Resin HemoperfusionCARL LAWYER, M.D., JACK AITCHISON, Ph.D., JAMES SUTTON, M.D., WILLIAM BENNETT, M.D., F.A.C.P.CARL LAWYER, M.D.Search for more papers by this author, JACK AITCHISON, Ph.D.Search for more papers by this author, JAMES SUTTON, M.D.Search for more papers by this author, WILLIAM BENNETT, M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-88-4-516 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptHigh plasma concentrations of theophylline may be associated with seizures (1). Patients who manifest such seizures often have liver disease. The seizures are often refractory to intravenous diazepam, phenytoin, and phenobarbital. Mortality from theophylline neurotoxicity is high. Indeed, Zwillich and co-workers (1) reported a 50% mortality in their series of eight patients. Resin hemoperfusion, although proven effective in barbiturate overdoses (2), has not been previously used for treatment of theophylline neurotoxicity.A 50-year-old white woman with chronic alcoholism was hospitalized because of jaundice and increasing ascites. She had previously received various theophylline preparations for episodic asthma. Physical findings at admission...References1. ZWILLICHSUTTONNEFFCOHNMATTHAYWEINBERGER CFTWRM: Theophylline-induced seizures in adults. Correlation with serum concentrations. Ann Intern Med 82:784-787, 1975 LinkGoogle Scholar2. ROSENBAUMKRAMERRAJABOREYKO JMRC: Resin hemoperfusion: a new treatment for acute drug intoxication. N Engl J Med 284:874-877, 1971 CrossrefMedlineGoogle Scholar3. FRIELTROUPIN PA: Flash heater ethylation of some anti-epileptic drugs. Clin Chem 21:6-9, 1975 CrossrefGoogle Scholar4. ROSENBAUMMARDANAS JR: Treatment of phenobarbital intoxication in dogs with an anion-recirculation peritoneal dialysis technique. Trans Am Soc Artif Intern Organs 13:183-189, 1967 Google Scholar5. LEVYGIBSONWHITMANPROCKNAL GTWJ: Hemodialysis clearance of theophylline. JAMA 237:1466-1467, 1977 CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: University of Oregon Health Sciences Center and Veterans Administration Hospital Portland, Oregon PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByExtracorporeal treatment for theophylline poisoning: Systematic review and recommendations from the EXTRIP workgroupTreatment of theophylline overdoseCharcoal Hemoperfusion for Theophylline Overdose: Case Report and Proposal for Predicting Treatment TimeDrug- and Toxin-Induced SeizuresAdenosine Receptors are not Involved in Theophylline-Induced SeizuresTheophylline toxicityThe Use of Hemodialysis and Hemoperfusion in the Treatment of Theophylline IntoxicationAcute Intoxication with Theophylline, Proxyphylline and Diprophylline in a 3-Month-Old Infant after Rectal Application: Pharmacokinetic Data under HemoperfusionPharmacological Considerations for Renal Failure and DialysisExtracorporeal techniques in the treatment of exogenous intoxicationsEvaluation of theophylline overdoses and toxicitiesMethylxanthines: Toxicity to humans. 1. TheophyllineGuide to Therapy with Theophylline for the Treatment of Obstructive Lung DiseaseRole of Extracorporeal Drug Removal in Acute Theophylline PoisoningAminophylline ToxicityTheophylline PoisoningMassive Theophylline Intoxication: Effects of Charcoal Haemoperfusion on Plasma and Erythrocyte Theophylline ConcentrationsTreatment of Theophylline Toxicity with Oral Activated Charcoal*THERAPEUTIC PROGRESS—REVIEW XIII.Severe theophylline toxicityDiuresis, Dialysis, and Hemoperfusion Indications and BenefitsTreatment of Oral Theophylline PoisoningTreatment of Oral Theophylline PoisoningTelomerization of Dienes by Homogeneous Transition Metal CatalystsBenefit of Hemoperfusion in Acute Theophylline IntoxicationAminophylline IntoxicationComparative Pharmacokinetics of Theophylline in Peritoneal Dialysis and HemodialysisUse of hemoperfusion for treatment of theophylline intoxicationPharmacological Aspects of Renal Failure and DialysisPharmacokinetic characterization of extracorporeal therapyAcute PoisoningPeritoneal Clearance of TheophyllineAsymptomatic Theophylline OverdoseTHE EVALUATION, CONTROL, AND MODIFICATION OF CONTINUING ASTHMAResin hemoperfusion in dogs intoxicated with ethchlorvynol (Placidyl®)Acac (Albumin-Collodion Coated Activated Charcoal) Hemoperfusion: In-Vitro Removal and Clearance of TheophyllineCurrent Status of Hemoperfusion in ToxicologyHemoperfusion for Acute Intoxications: ConHemoperfusion to Treat IntoxicationsJONATHAN A. LORCH, M.D., SERAFINO GARELLA, M.D.Resin Hemoperfusion as Treatment for Theophylline-induced SeizuresManagement of Theophylline Intoxication with Charcoal-Column Hemoperfusion 1 April 1978Volume 88, Issue 4Page: 516-517KeywordsAlcoholismAscitesAsthmaAttentionBlood plasmaDiazepamEpileptic seizuresHemoperfusionLiver diseasesMortality Issue Published: 1 April 1978 PDF DownloadLoading ...