FURTHER OBSERVATIONS ON THE TREATMENT OF TYPHUS FEVER WITH PARA-AMINOBENZOIC ACID
Authors: J C SNYDER, A YEOMANS
Journal: Annals of Internal Medicine (1947)

Article1 July 1947FURTHER OBSERVATIONS ON THE TREATMENT OF TYPHUS FEVER WITH PARA-AMINOBENZOIC ACIDJ. C. SNYDER, M.D., A. YEOMANS, M.D., D. H. CLEMENT, M.D., E. S. MURRAY, M.D., C. J. D. ZARAFONETIS, M.D., N. A. TIERNEY, M.D.J. C. SNYDER, M.D.Search for more papers by this author, A. YEOMANS, M.D.Search for more papers by this author, D. H. CLEMENT, M.D.Search for more papers by this author, E. S. MURRAY, M.D.Search for more papers by this author, C. J. D. ZARAFONETIS, M.D.Search for more papers by this author, N. A. TIERNEY, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-27-1-1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe therapeutic effect of para-aminobenzoic acid (PABA) in experimental murine typhus infection of white mice was reported in 1942.1 Subsequently, evidence bearing on the action of PABA in experimental rickettsial infections has been obtained in several laboratories. In the yolk sac membrane of developing chick embryos, PABA or its sodium salt inhibits the multiplication of Rickettsia mooseri,2, 3R. prowazeki,2, 4, 5R. orientalis,5 and Dermacentroxenus rickettsi.4 The mortality in experimental rickettsial infections in white mice,1, 6 gerbilles,7, 8, 9 cotton rats,10 and guinea pigs11 is considerably reduced by PABA.In 1944 a favorable therapeutic effect from the administration of...Bibliography1. 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Author, Article, and Disclosure InformationAffiliations: *Received for publication March 18, 1947.From the United States of America Typhus Commission, War Department, Washington, D. C., and the Laboratories of the International Health Division of The Rockefeller Foundation, New York. Nextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byKlinik der RickettsiosenKlinik der RickettsiosenTHE CONTROL OF SCRUB TYPHUS IN NIIGATA PREFECTURE 1949. II. TREATMENT OF SCRUB TYPHUS IN NIIGATA WITH PABA AND CHLOROMYCETINFurther Studies on the Treatment of Lupus Erythematosus with Sodium Para-Aminobenzoate11From the Departments of Internal Medicine and Dermatology and Syphilology, University Hospital, Ann Arbor, Michigan.ACTION OF AUREOMYCIN AGAINST EXPERIMENTAL RICKETTSIAL AND VIRAL INFECTIONSNature of Inhibition of Ultraviolet Erythema by Pyribenzamine11From the New York Skin and Cancer Unit, Department of Dermatology and Syphilology, of the New York Post-Graduate Medical School and Hospital (Dr. Marion B. Sulzberger, Director).The Treatment of Rickettsial DiseasesVitamins as Pharmacologic Agents 1 July 1947Volume 27, Issue 1Page: 1-27KeywordsCyclic adenosine monophosphateFeversKidneysLesionsLymphocytesMyocarditisPlasma cellsRocky Mountain spotted feverSurgeonsTyphus ePublished: 1 December 2008 Issue Published: 1 July 1947 Copyright & PermissionsCopyright, 1947, by The American College of PhysiciansPDF downloadLoading ...