LIMITS TO FUNCTIONAL HYPERTROPHY IN HIGH-OUTPUT FAILURE
Authors: John H. Frenster
Journal: Annals of Internal Medicine (1960)

Article1 October 1960LIMITS TO FUNCTIONAL HYPERTROPHY IN HIGH-OUTPUT FAILUREJOHN H. FRENSTER, M.D.JOHN H. FRENSTER, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-53-4-647 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptINTRODUCTIONHigh-output failure in man has been described both for cardiac blood propulsion1and for bone marrow erythropoiesis,2but it also occurs in a wide variety of processes in other organs. It seems implicit in all descriptions of "relative failure" or "relative insufficiency" of the function of an organ.2The usual response of an organ process when it remains subjected to increased loads is a secondary increase in the capacity to perform the affected function. Such functional hypertrophy has limits, beyond which the increased capacity becomes inadequate for the increasing load. 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Frenster, M.D., The Rockefeller Institute, New York 21, N. Y. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByAnalysis of Queueing and Renewal within Human SystemsLoad Tolerance as a Quantitative Estimate of HealthJOHN H. FRENSTER, M.D.The magnitude of disease as measured by tolerance tests 1 October 1960Volume 53, Issue 4Page: 647-655KeywordsBloodBone marrowBone marrow failureFellowships Issue Published: 1 October 1960 PDF DownloadLoading ...