THE USE OF PROCAINE AMIDE IN THE TREATMENT AND PREVENTION OF PENICILLIN REACTIONS
Authors: P B JENNINGS, S OLANSKY
Journal: Annals of Internal Medicine (1954)

Article1 April 1954THE USE OF PROCAINE AMIDE IN THE TREATMENT AND PREVENTION OF PENICILLIN REACTIONSPAUL B. JENNINGS, M.D., SIDNEY OLANSKY, M.D.PAUL B. JENNINGS, M.D.Search for more papers by this author, SIDNEY OLANSKY, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-40-4-711 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptDuring the past few years there has been an increasing number of penicillin reactions. The number is expected to continue increasing as more people are exposed to the drug, since they then will be likely to become sensitized. Anaphylactic reactions and even deaths have been reported.1It is apparent that there is a need for more satisfactory methods of treating these reactions and of preventing them in known reactors. Many forms of treatment have been used, but they have not proved to be entirely satisfactory. Among the most commonly used are the antihistaminics, ephedrine, epinephrine, intravenous procaine, ACTH and cortisone....Bibliography1. MayerMoskoSchutzOstermanSteenBaker PSMMPJFALHLA: Penicillin anaphylaxis, J. A. M. A. 151: 351-353 (Jan. 31) 1953. MedlineGoogle Scholar2. BordleyHarveyHowardNewman JEAMJEEV: Preliminary report on the use of ACTH in hypersensitive state, Proc. First Clinical ACTH Conference, 1950, The Blakiston Company, Philadelphia, pp. 469-478. Google Scholar3. HenslerWurlGillespie NMOAJO: The use of cortisone and ACTH in treating reactions to penicillin, U. S. Armed Forces M. J. 3: 199-206 (Feb.) 1952. MedlineGoogle Scholar4. PeinerWaldman LS: Effective therapy of severe penicillin reactions with sodium dehydrocholate. Clinical studies of liver dysfunction—XII, Am. Pract. and Digest Treat. 3: 293-296 (Apr.) 1952. MedlineGoogle Scholar5. KerrBrehm RMWF: Intravenous procaine. An evaluation of some of its uses, Postgrad. Med. 8: 444-453 (Dec.) 1950. CrossrefMedlineGoogle Scholar6. CohenKaufman AEJ: The use of procaine hydrochloride intravenously in the treatment of reactions to penicillin, J. Allergy 19: 68-70 (Jan.) 1948. CrossrefMedlineGoogle Scholar7. SchapiroSadove MMMS: Oral procaine hydrochloride therapy in asthma, Ann. Allergy 8: 85-89 (Jan.-Feb.) 1950. MedlineGoogle Scholar8. Luddecke H: Oral administration of procaine with ascorbic acid, with special reference to therapy of pruritus, Arch. Dermat. and Syph. 64: 9-11 (July) 1951. CrossrefGoogle Scholar9. Friedman TB: Personal communication to authors. Google Scholar10. Hellman E: Allergy to procaine amide, J. A. M. A. 149: 1393-1394 (Aug. 9) 1952. CrossrefMedlineGoogle Scholar11. StearnsCallahanEllis NSEJLB: Value and hazards of intravenous procaine amide (Pronestyl) therapy, J. A. M. A. 148: 360-364 (Feb. 2) 1952. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: *Received for publication September 25, 1953. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byTreatment of procaine amide intoxicationAntibiotikaAntibiotikaBenzathine Penicillin in the Management of the TreponematosesThe vexing urticaria problem: Present concepts of etiology and management 1 April 1954Volume 40, Issue 4Page: 711-720KeywordsAdrenocorticotropic hormoneAnaphylaxisDrugsEpinephrineMedical servicesPenicillin ePublished: 1 December 2008 Issue Published: 1 April 1954 PDF downloadLoading ...