Nonsteroidal Anti-Inflammatory Drugs and Renal Disease—Still Unsettled
Authors: Edward H. Wagner
Journal: Annals of Internal Medicine (1991)

Editorials1 August 1991Nonsteroidal Anti-Inflammatory Drugs and Renal Disease—Still UnsettledEdward H. Wagner, MD, MPHEdward H. Wagner, MD, MPHSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-115-3-227 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe evidence of an association between nonsteroidal anti-inflammatory drugs (NSAIDs) and renal disease has acquired an all-too-familiar and frustrating pattern—a plausible biologic mechanism and many small reports showing acute toxicity. Yet, no large-scale clinical trials or epidemiologic studies have confirmed the risk in the population. Murray and Brater (1), in a recent editorial, suggested that "well-executed epidemiologic studies using richer clinical databases will not only cause convergence with the findings from interventional studies (and case reports) but will also provide quantitative information on putative risk factors for NSAID-associated renal effects." In this issue of Annals, the study by Sandler and...References1. Murray M and Brater D. Adverse effects of nonsteroidal anti-inflammatory drugs on renal function. Ann Intern Med. 1991;112:559-60. LinkGoogle Scholar2. Sandler D, Burr F, and Weinberg C. Non-aspirin nonsteroidal anti-inflammatory drugs and risk of chronic renal disease. Ann Intern Med. 1991;115:000-000. LinkGoogle Scholar3. Feinstein A and Horwitz R. Double standards scientific methods and epidemiologic research. N Engl J Med. 1982;307:1611-7. CrossrefMedlineGoogle Scholar4. Fletcher R, Fletcher S, and Wagner E. Clinical epidemiology—the essentials. 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Wagner, MD, MPHAffiliations: Center for Health Studies Group Health Cooperative of Puget Sound PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byRenal expression of COX-2, ANG II, and AT 1 receptor in remnant kidney: strong renoprotection by therapy with losartan and a nonsteroidal anti-inflammatoryGuidelines for monitoring drug therapy in rheumatoid arthritisThe Ageing Kidney: Practical Considerations in the Management of the Elderly Patient with Renal DiseaseAnti-inflammatory analgesics and drugs used in rheumatoid arthritis and gout 1 August 1991Volume 115, Issue 3Page: 227-228KeywordsAdverse reactionsBiologicsClinical epidemiologyClinical trialsDatabasesMedical risk factorsNSAIDsRenal diseasesRisk managementToxicity ePublished: 1 December 2008 Issue Published: 1 August 1991 PDF downloadLoading ...