tbuckley/cabot-search huggingface dataset:
Abstract 12538: A Novel Method to Therapeutic Angiogenesis by Sustained Release of Basic Fibroblast Growth Factor Using Biodegradable Gelatin Hydrogel Sheet in a Canine Chronic Myocardial Infarction Model
Authors: Motoyuki Kumagai, Akira Marui, Yasuhiko Tabata, Eiji Yoshikawa, Masaya Yamamoto, Atsushi Yonezawa, Shiro Tanaka, Takafumi Ikeda, Hidetoshi Masumoto, Tomohiro Nakata, Hisashi Sakaguchi, Kenji Minakata, Kazuhiro Yamazaki, Tadasi Ikeda, Masayuki Yokode, Akira Shimizu, Ryuzo Sakata
Journal: Circulation (2014)

Background:  As therapeutic angiogenesis, we have ever used basic fibroblast growth factor (bFGF) with gelatin hydrogel (GH) for covering problems of gene therapy and shown the efficacy in several animal and clinical studies. This study investigated the safety and efficacy of a sustained release of bFGF with biodegradable GH sheet in canine chronic myocardial infarction (MI) models.   Methods:  First, we evaluated the safety in accordance with standards of Good Laboratory Practice in 9 dogs. Saline or bFGF with GH sheets were covered the left ventricular wall and we evaluated the heats and other organs by immunohistochemical studies after 4 weeks in three groups: saline group (n=3), low-dose group (40μg bFGF, n=3), high-dose group (200μg bFGF, n=3). Secondly, we evaluated the efficacy in 12 dogs. Canine chronic MI models were induced by ligation of the left anterior descending coronary artery and its diagonal branches. At 4 weeks later, saline or bFGF with GH sheets were covered the ischemic area of left ventricular wall: control group (saline, n=5) and bFGF group (200μg bFGF, n=7). At 6 weeks after treatment, we evaluated the efficacy by immunohistochemical and echocardiographic studies.   Results:  Regarding the safety, the blood levels of bFGF were not detected in all groups and histological abnormalities of heart or other organs were not shown in all groups at 4 weeks. Concerning the efficacy, bFGF with GH sheet improved fractional shortening significantly (18.8% ± 1.9% and 11.9% ± 1.4% in the bFGF and control groups, respectively, p   Conclusions:  Therapeutic angiogenesis by bFGF using biodegradable GH sheet was safe, increased the capillary density, and improved left ventricular function in canine chronic MI models, so it may be a capable strategy for treating chronic MI patients.
Effect of a Health Maintenance Organization on Physiologic Health
Authors: Elizabeth M. Sloss, Emmett B. Keeler, Robert H. Brook, Belinda H. Operskalski, George A. Goldberg, Joseph P. Newhouse
Journal: Annals of Internal Medicine (1987)

Abstract In a previous comparison of persons between 14 and 62 years of age randomly assigned to receive care through a fee-for-service system (n= 784) or through a health maintenance organization ...
Association analysis of NOTCH4 loci in schizophrenia using family and population-based controls
Authors: Pamela Sklar, Sibylle G. Schwab, Nigel M. Williams, Mark Daly, Stephen Schaffner, Wolfgang Maier, Margot Albus, Matyas Trixler, Peter Eichhammer, Bernard Lerer, Joachim Hallmayer, Nadine Norton, Hywel Williams, Stan Zammit, Alastair G. Cardno, Sue Jones, Geraldine McCarthy, Vihra Milanova, George Kirov, Michael C. O'Donovan, Eric S. Lander, Michael J. Owen, Dieter B. Wildenauer
Journal: Nature Genetics (2001)
Intravenous beta blockade in acute myocardial infarction
Authors: K L Woods, D Ketley, P. F Ludman, K. Hardy, S. O'Brien
Journal: BMJ (1999)

Deprivation and emergency admissions for cancersOther possible explanations for findings need to be explored Editor-The reasons for Pollock and Vickers's findings about the relation between deprivation and emergency admissions for cancers remain speculative. 1To impute the differences in care to failures of primary care seems unfair at this stage.The authors discuss a range of possible explanations, but many other could also be relevant.Day case treatment may require a certain level of facilities at home that are less commonly available in deprived areas.The presence of another adult at home may also be a prerequisite.Single people may be more likely to live in deprived areas; patients from deprived areas may be more likely to have a working partner who cannot afford to take time off work or who has a job where such absences would be unacceptable.Patients with lung cancer due to smoking (more common in areas where smoking is more prevalent) may be less likely to have an operable malignancy because of concomitant disease related to smoking.The authors mention this in their discussion, but limiting the study to inpatient finished consultant episodes with a primary diagnosis of any of the three cancers of interest does not give any information about comorbidity.I hope further research will be carried out to help elucidate the reasons behind the apparently inequitable access and treatment decisions that Pollock and Vickers have found.Both qualitative and quantitative research methods could be used to study patients' and professionals' experiences as patients pass through the system.Perhaps allocation of blame should wait until such results are available.
Asthma control or mental lack of control? Are they related?
Authors: Roser Poblet, Xavier Flor, Laia Lamarca, Judit Mendez, M. Victoria Feijoo, Silvia Alvarez
Journal: European Respiratory Journal (2011)

Background:  The association between asthma and mental disorders is known, being anxiety and depression the most common ones.   Objective:  To determine the proportion of mental disorders (anxiety and/or depression) in our asthmatic patients compared to the non asthmatic population, and to assess the relationship between the severity and control level of asthma and the presence of psychiatric comorbility.   Methods:  A transversal descriptive study was developed with 317 asthmatic and 306 non asthmatic patients, from 17 to 70 years old in an urban primary care centre. The Goldberg test for screening of anxiety and depression was performed. Other analyzed items were: age, gender, previous anxiety and/or depression, chronic diseases, severity of asthma and level of control.   Results:  70.3% of the asthmatic patients were women versus 51.3% on the non asthmatic group, the average age was 42 (SD 16.89) and 47 (SD 14.09) years old respectively. 57.1% had intermittent asthma, 16.7% mild persistent and 26.2% moderate persistent. 62.7% presented controlled asthma, 23.4% partially controlled and 13.9% uncontrolled asthma. The Goldberg test score of the asthmatic group showed anxiety in 51.1% compared to 34.6% on the non asthmatic group (p   Conclusions:  The asthmatic group showed greater proportion of anxiety and depression compared to the non asthmatic group. Better asthma control was associated with lower anxiety and depression. No other associations were significant.
Speculations on the Role of Ultraviolet Radiation in the Development of Malignant Melanoma4
Authors: Margaret L. Kripke
Journal: JNCI Journal of the National Cancer Institute (1979)

Interest in the etiology of human malignant melanoma has increased considerably in recent years. The basis for this heightened concern can be attributed to two seemingly unrelated issues. The first is that the incidence of malignant melanoma is increasing at an alarming rate. At the present time, both the incidence of melanoma and the mortality rate are doubling every 10 to 17 years. Thus identification of causal factors in the development of melanoma is an urgent necessity if this upward trend is to be curbed. The second issue that has directed attention to the identification of etiologic factors in malignant melanoma is ozone depletion. The layer of ozone surrounding the earth shields it from solar uv radiation. Anticipated decreases in stratospheric ozone, resulting from high-altitude aircraft, nuclear explosions, and the release into the atmosphere of chlorofluoromethanes from refrigerants and aerosol sprays, raised concerns about the effects of an increased exposure of all life forms to uv light. One anticipated effect of increased exposure of humans to uv light is a corresponding increase in some types of skin cancer in humans. If malignant melanoma is included among the types of skin cancer at risk of increasing, then the impact of ozonemore » depletion on humans is serious indeed. In the prognosis for melanoma is less favorable, particularly in cases in which the tumor is already invasive at the time of diagnosis. Thus the threat of an increased level of exposure to light has stimulated a careful reevaluation of the role of radiation in the induction of melanoma.« less
Further demonstration of the diversity of chromosomal changes involving 2p23 in ALK-positive lymphoma: 2 cases expressing ALK kinase fused to CLTCL (clathrin chain polypeptide-like)
Authors: Christian Touriol, Catherine Greenland, Laurence Lamant, Karen Pulford, Frédéric Bernard, Thérèse Rousset, David Y. Mason, Georges Delsol
Journal: Blood (2000)
Human papillomavirus-associated increase in p16INK4A expression in penile lichen sclerosus and squamous cell carcinoma
Authors: D.M. Prowse, E.N. Ktori, D. Chandrasekaran, A. Prapa, S. Baithun
Journal: British Journal of Dermatology (2007)

Background Human papillomaviruses (HPVs) are sexually transmitted human carcinogens that may play a role in the oncogenesis of penile cancer. Objectives To investigate the role of HPV infection and expression of the tumour suppressor protein p16INK4A in the pathogenesis of penile cancer. Methods By means of polymerase chain reaction amplification and reverse hybridization line probe assay to detect HPV infection, and immunohistochemical staining for p16INK4A and Ki67, we analysed 26 penile squamous cell carcinomas (SCCs) and 20 independent penile lichen sclerosus (LS) lesions from 46 patients. Results HPV DNA was found in 54% of penile SCCs and 33% of penile LS cases in single and multiple infections. High‐risk HPV 16 was the predominant HPV type detected. No relationship between Ki67 expression and HPV infection was observed. Strong immunostaining for p16INK4A correlated with HPV 16/18 infection in both penile LS and penile SCC. In our penile SCC series the cancer margins were also associated with penile LS in 13 of 26 lesions, and HPV was detected in seven of the 13 SCC cases associated with LS and in six of the 11 SCC lesions not involving LS. Conclusions Our study shows a high prevalence of HPV 16 and p16INK4A expression in penile lesions, consistent with an active role for HPV in interfering with the retinoblastoma pathway. High‐risk HPV infection could be involved in the tumorigenic process in 50% of penile cancers, and the use of prophylactic HPV vaccines has the potential to prevent these cancers.
Involvement of tumor necrosis factor-related apoptosis-inducing ligand in surveillance of tumor metastasis by liver natural killer cells
Authors: Kazuyoshi Takeda, Yoshihiro Hayakawa, Mark J. Smyth, Nobuhiko Kayagaki, Noriko Yamaguchi, Shigeru Kakuta, Yoichiro Iwakura, Hideo Yagita, Ko Okumura
Journal: Nature Medicine (2001)
Compression for leg wounds
Authors: H. Partsch, P. Mortimer
Journal: British Journal of Dermatology (2015)

The main points in this scholarly review on the use of compression therapy in leg ulcers are the different modes of action of this treatment and the tools that are available including their practical applicability and use for self management. Due to its effect of counteracting gravity, compression is also suggested for ulcers with aetiologies that are not usually thought to require compression. The clinical evidence reported in ulcer‐healing studies are discussed and some considerations are made relating to the cost‐effectiveness of this management. In general, the failures of compression therapy are not caused by poor compression material but due to poor knowledge and application techniques of the care providers. Future studies comparing different compression devices should also report details concerning the compression material used and the pressure exerted.
Latent Infection and Reactivation of Human Herpesvirus 6 in Two Novel Myeloid Cell Lines
Authors: Masaki Yasukawa, Hideki Ohminami, Eiji Sada, Yoshihiro Yakushijin, Masahiko Kaneko, Kohsuke Yanagisawa, Hidehisa Kohno, Shiro Bando, Shigeru Fujita
Journal: Blood (1999)
Abstract 18290: Warfarin Use is Associated With Reduced Mortality in Patients with Left Ventricular Systolic Dysfunction and Pulmonary Hypertension
Authors: Andrew Goudie, Douglas Elder, Alan Robertson, Allan D Struthers, Chim Lang, Ben Szwejkowski
Journal: Circulation (2011)

Background: The presence of pulmonary hypertension in patients with left ventricular systolic dysfunction (LVSD) results in an additional increase in mortality. In pulmonary hypertension pathological changes within the lung microcirculation include thrombosis, even in the absence of clinically manifest thromboembolic disease. However, anticoagulation for pulmonary hypertension in those with LVSD is controversial, unless coexistent thromboembolic disease or atrial fibrillation is evident. Methods: The Tayside echocardiography database was linked to dispensed prescribing, laboratory and hospital admission coding data as well as the national death registry. All patients undergoing echocardiography between 1994 and 2007 with LVSD and an RVSP of greater than 35 mmHg were included. Patients with pulmonary embolism prior to study entry were excluded. Cox regression was used to assess the influence of warfarin prescription on mortality, adjusting for known confounders. Results: Study criteria were met by 2419 patients (mean age, 73.91 ± 11.5 years; 57% male). Mean RVSP for the cohort was 42.8 ± 12.5 mmHg with 1078 deaths during a mean follow-up of 2.06 years. Warfarin was prescribed to 1,086 (45%) of this cohort. In the multivariate proportional hazards model, the adjusted HR for warfarin use was 0.78, 95% CI [0.67 - 0.90], p = 0.001. A similar result was obtained in the propensity score analysis. Conclusion: Warfarin use was associated with reduced mortality in those with LVSD and pulmonary hypertension. Adequately designed prospective randomised controlled trials are required to validate this finding given the limitations of this observational study.
Volunteers See the World and Help Its People
Authors: Brian Vastag
Journal: JAMA (2002)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Drug points: Hepatotoxicity associated with zolpidem treatment
Authors: D. Karsenti, P. Blanc, Y. Bacq, E.-H. Metman
Journal: BMJ (1999)

Zolpidem is a hypnotic drug of the imidazopyridine group. Another imidazopyridine, alpidem, has been withdrawn from the market because of its hepatotoxicity. 1 2 Hepatoxicity has been suspected in association with zolpidem, but it has not been clearly established because of concomitant drug treatment. 3 4 We report a case of acute hepatitis mimicking biliary lithiasis after treatment with zolpidem alone at a therapeutic dose, with reappearance of the hepatoxicity after the drug was reintroduced.

A 53 year old woman was admitted in June 1997 for investigation of recurrent abdominal pain. She had no history of recent …
Plasma protein adsorption on biodegradable microspheres consisting of poly(d,l-lactide-co-glycolide), poly(l-lactide) or ABA triblock copolymers containing poly(oxyethylene)
Authors: Martin Lück, Karin-Frauke Pistel, You-Xin Li, Torsten Blunk, Rainer H Müller, Thomas Kissel
Journal: Journal of Controlled Release (1998)
Epibulbar Molluscum Contagiosum in Acquired Immune Deficiency Syndrome
Authors: Norman C. Charles, Dorothy N. Friedberg
Journal: Ophthalmology (1992)

Background: While molluscum contagiosum of the eyelid skin is commonly complicated by conjunctivitis, primary involvement of the conjunctiva or cornea by molluscum lesions is exceedingly rare. The authors studied a 34-year-old man with acquired immune deficiency syndrome (AIDS) in whom multiple molluscum lesions of the lids and a single nodule of the limbus developed. Methods: The nodular lesion was excised from the limbus and processed for histologic examination by light microscopy. Pertinent literature concerning epibulbar molluscum contagiosum was reviewed. Results: Histopathology of the excised lesion showed molluscum bodies within the acanthotic, hyperkeratotic conjunctival epithelium with surrounding chronic, nongranulomatous inflammation. Only 10 previous cases of conjunctival or corneal primary lesions have been reported, half of which showed associated cutaneous involvement. Lesions tended to be single, noninflamed, dome-shaped, and umbilicated, often with a yellowish central core. Patients were otherwise well and ranged in age from 3 to 55 years. Simple excision was effective in eradicating the lesions. Conclusion: Primary epibulbar molluscum contagiosum is rare. Although cutaneous molluscum is common in AIDS, this report is the first to document conjunctival molluscum in a patient with AIDS. Background: While molluscum contagiosum of the eyelid skin is commonly complicated by conjunctivitis, primary involvement of the conjunctiva or cornea by molluscum lesions is exceedingly rare. The authors studied a 34-year-old man with acquired immune deficiency syndrome (AIDS) in whom multiple molluscum lesions of the lids and a single nodule of the limbus developed. Methods: The nodular lesion was excised from the limbus and processed for histologic examination by light microscopy. Pertinent literature concerning epibulbar molluscum contagiosum was reviewed. Results: Histopathology of the excised lesion showed molluscum bodies within the acanthotic, hyperkeratotic conjunctival epithelium with surrounding chronic, nongranulomatous inflammation. Only 10 previous cases of conjunctival or corneal primary lesions have been reported, half of which showed associated cutaneous involvement. Lesions tended to be single, noninflamed, dome-shaped, and umbilicated, often with a yellowish central core. Patients were otherwise well and ranged in age from 3 to 55 years. Simple excision was effective in eradicating the lesions. Conclusion: Primary epibulbar molluscum contagiosum is rare. Although cutaneous molluscum is common in AIDS, this report is the first to document conjunctival molluscum in a patient with AIDS.
Ferulik asitle stabilize edilen E ve C vitaminleri içeren topikal bir antioksidan solüsyon, ultraviyole ışınının neden olduğu hasara karşı insan derisini korumaktadır
Authors: John C. Murray, James A. Burch, Robert D. Streilein, Mary Ann Iannacchione, Russell P. Hall veSheldon R. Pinnell Durham, North Carolina
Journal: Journal of the American Academy of Dermatology (2008)
NICE指南：5岁以下小儿发热首诊诊断和治疗措施——英国国家卫生和临床医疗优选研究所指南概要
Authors: Martin, Richardson, Monica, Lakhanpaul, 田悦（译）, 魏冰（校）, 杜军保（校）
Journal: BMJ (2007)

为什么阅读本概要？ 在英国，传染病仍然是儿童死亡和发病的一个重要原因（卫生部R MacFaul的私人通信），这与缺乏医疗保健有直接关系。发热患儿一般都存在潜在的感染，但感染病因的确诊却并不是那么容易。由于缺乏国家统一的标准，英国各地对发热性疾病的处理都各不相同。改进此类疾病的诊断和治疗是我们当前亟待解决的问题。本文总结了英国国家卫生和临床医疗优选研究所（NICE）关于5岁以下小儿发热首诊诊断和治疗措施的指导意见。
Dermatoskopi için 7 maddelik kontrol listesinin artmış melanom riski olan hastaların 1 yıllık prospektif izlemi boyunca performansı
Authors: Holger A. Haenssle, Bianca Korpas, Christian Hansen-Hagge, Timo Buhl, Kjell M. Kaune, Albert Rosenberger, Ullrich Krueger, Michael P. Schön, veSteffen Emmert
Journal: Journal of the American Academy of Dermatology (2010)
Warning on Serzone
Authors: Bernard A. Schwetz
Journal: JAMA (2002)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
A new prognostic scoring system for meningococcal septic shock in children. Comparison with three other scoring systems
Authors: Álvaro Castellanos-Ortega, Miguel Delgado-Rodríguez, Javier Llorca, Pilar Sánchez Burón, Santiago Mencía Bartolomé, Juan Soult Rubio, Guillermo Milano Manso, Pedro Domínguez Sampedro, Ramiro Blanco Montero, Antonio Rodríguez Núñez, Elisa Zambrano Pérez, Corsino Rey Galán, Nuria López Negueruela, Roberto Reig Sáenz
Journal: Intensive Care Medicine (2002)