tbuckley/cabot-search huggingface dataset:
Noninvasive ventilation (NIV) after lung resection (LR) to prevent respiratory complications (RCs) in COPD patients (pts) (POPVNI trial)
Authors: Christina Lorut, Aurelie Lefebvre, Benjamin Planquette, Herve Clavier, Nicola Santelmo, Alain Bernard, Francois Bellenot, Jean Francois Regnard, Marc Riquet, Pierre Magdeleinat, Guy Meyer, Nicolas Roche, Gerard Huchon, Joel Coste, Antoine Rabbat
Journal: European Respiratory Journal (2011)

Background:  RCs are common following LR in COPD pts. NIV decreases the rates of tracheal intubation and mortality in post-operative (PO) acute respiratory failure. The aim of our study is to prophylactic NIV for prevention of RCs in the immediate PO care of pts with COPD.   Patients and methods:  This multicenter, prospective, randomised, parallel, open ended study planned to enrol 360 pts with moderate to severe COPD scheduled for LR. Patients were randomized to standard treatment without or with NIV during the 3 first PO days. The primary outcome is the incidence of acute respiratory events (AREs), defined as the occurrence of at least two of the following: RR >30/mn, PaO2/FiO2 ≤200 mmHg, >10 mmHg increase in PaCO2 or a new pulmonary infiltrate on chest X Ray. Secondary outcomes are the incidence of RCs, rescue NIV use, invasive ventilation requirements, mortality rate, duration of ICU and hospital stay. Univariate and multivariate analysis will identify subgroups who benefit more from NIV.   Results:  351 pts, 277 men (79%) and 74 women (21%) were effectively included in 6 centres between June 2008 and October 2010. Mean age (±SD) is 62±9 years. Mean pre-operative FEV1 is 62±11% predicted. Pts numbers in GOLD stage II, III and IV are 295 (83.4%), 44 (12.5%) and 4 (1.1%), respectively. There is no difference in baseline patients9 characteristics at inclusion between the control group (n = 174) and NIV group (n = 177).   Conclusion:  Comparability of the 2 groups at baseline will allow reliable comparisons of outcomes (which will be available at the ERS meeting) between PO NIV and standard care following LR in GOLD stage II-III COPD patients.
Still Life With Game
Authors: M. Therese Southgate
Journal: JAMA (2002)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Abstract 17468: Left Ventricular Remodeling Index (LVRI) in patients after breast cancer therapy in the long-term follow-up
Authors: Felix Heggemann, Hanna Buggisch, Grit Welzel, Christina Doesch, Jochen Hansmann, Stefan O Schoenberg, Martin Borggrefe, Frederik Wenz, Theano Papavassiliu, Frank Lohr
Journal: Circulation (2014)

Introduction: Cardiotoxic side effects are of concern in long-term survivors of left-sided breast cancer therapy. 3-dimensional conventional radiotherapy (3DCRT) deposits high doses in defined regions of the heart. Intensity modulated radiotherapy (IMRT) reduces local high-dose exposition at the expense of exposing more heart tissue to lower doses. Cardio-MRI was performed in this study to assess MRI-morphologic and functional alterations after 3DCRT and IMRT/ additional chemotherapy, with IMRT only performed in patients that would have been exposed to unacceptably high heart doses with 3DCRT. Methods: 49 patients with left-sided breast cancer (38 3DCRT and 11 IMRT; 20 patients with additional adjuvant chemotherapy (ACH) (13 3DCRT, 7 IMRT) were included prospectively. Baseline (pre-treatment) and 24 months post-treatment MRI was performed. With MRI, enddiastolic left ventricular mass (LVM), enddiastolic left ventricular volume (LVEDV) and stroke volume (SV) were assessed. LVRI was calculated with the formula LVM/LVEDV. Results: Mean dose for the whole heart was higher in IMRT than in 3DCRT patients (12.9±3.9 vs. 4.5 ±2.4 Gy). Larger regions received a higher radiation dose (&gt;40Gy) in 3DCRT than in IMRT patients (3.3% vs. 1.3% of the whole heart). High local radiation dose &gt; 50 Gy only occurred in the 3DCRT group (0.74% of the heart volume). After 24 months LVRI decreased significantly in patients with ACH (0.80 vs. 0.70, p=0.028). Non-significant decrease of LVRI was observed in the whole cohort (0.85 vs. 0.79), after IMRT (0.74 vs. 0.71), after 3DCRT (0.88 vs. 0.82) and without ACH (0.87 vs. 0.84). Decrease of LVRI in patients with ACH was caused by significant decrease of LVM (102.4 vs. 89.7 g, p=0.028) whereas LVEDV was stable (128.3 vs. 128.1g). In all groups, no significant decrease of SV could be assessed after 24 months. Conclusions: 24 months after therapy, significant decrease of LVRI due to decreased LVM could be found only in patients with additional chemotherapy. Radiotherapy alone did not have a significant impact on LVRI, LVM and SV. Low doses to the whole heart with IMRT did not cause significant decreases in LVRI, LVM and SV. LVM and LVRI are to be assessed in larger cohorts in patients with cancer therapy especially with additional chemotherapy.
EFFICACY OF HEAT-INACTIVATED HEPATITIS B VACCINE IN HAEMODIALYSIS PATIENTS AND STAFF
Authors: J. Desmyter, G. De Groote, J. Colaert, M. Reynders, E.E. Reerink-Brongers, P.J. Dees, P.N. Lelie, H.W. Reesink
Journal: The Lancet (1983)
Is the lung cancer in elderly similar to lung cancer in younger patients
Authors: Rihab Bay, Soumaya Ben Saad, Hafaoua Daghfous, Mouna Ben Khlifa, Hela Cherif, Fatma Tritar
Journal: European Respiratory Journal (2014)

Introduction: The increase in the number of elderly in Tunisia and of bronchogenic carcinoma (BC) incidence with age results in a steadily increase of the incidence of BC in the elderly.  Objective: Overview clinical, therapeutic and prognostic features of BC in elderly patients.  Methods: We conducted a retrospective and comparative study of 164 patients followed for BC between 2006 and 2012. Sixty three patients were 65 years old and over were included in the first group (G1) and the rest formed the second group (G2). We compared the clinical features, the management and prognosis of the 2 groups.  Results: Mean age was 72 years (G1) and 55 years (G2). Comorbidity was statistically more frequent in G1 (36,5% vs 28,7%; p  Conclusion: BC in elderly is marked by poor prognosis because of frequent comorbidity, low performans status, advanced stage of tumor and difficulty of use of invasive treatment.
Anion channel blockade: Effects upon erythrocyte membrane calcium response
Authors: John W. Eaton, Richard F. Branda, Christian Hadland, Kenneth Dreher
Journal: American Journal of Hematology (1980)

Abstract The influx of small amounts of calcium into normal human red cells adversely affects cellular metabolism, shape, ion and water content, and deformability. Because restriction of cation (potassium) efflux moderates these deleterious effects of Ca ++ influx, we investigated the possibility that inhibition of anion permeability might be similarly beneficial. Human red cells were treated with 4,4′‐diisothiocyano‐2,2′‐stilbene disulfonate (DIDS), which reacts preferentially with external sites on the transmembrane protein, band 3, and specifically inhibits inorganic anion transport. DIDS‐treated and control cells were then exposed to the ionophore A23187 and Ca ++ . We find that DIDS treatment blocks Ca ++ ‐induced K + and water loss and diminishes changes in osmotic fragility and cellular elasticity. Furthermore, DIDS reduces the “trapping” of hemoglobin by red cell membranes and increases the apparent affinity of the cell membrane for glyceraldehyde‐3‐phosphate dehydrogenase.
Response to “The Mysterious Disappearance of the Object of Inquiry: Jacobs and Arora's Defense of Circumcision”
Authors: Allan J. Jacobs, Kavita S. Arora
Journal: The American Journal of Bioethics (2015)

"Response to “The Mysterious Disappearance of the Object of Inquiry: Jacobs and Arora's Defense of Circumcision”." The American Journal of Bioethics, 15(8), pp. W4–W5
In Chinese adults with hypertension, adding folic acid to enalapril reduced incident stroke
Authors: David Barer
Journal: Annals of Internal Medicine (2015)

Source Citation Huo Y, Li J, Qin X, et al; CSPPT Investigators. Efficacy of folic acid therapy in primary prevention of stroke among adults with hypertension in China: The CSPPT randomized clinical trial. JAMA. 2015;313:1325-35. 25771069
Florodeoksiglukoz Pozitron Emisyon Tomografide Ölçülen Primer Tümör Standardize Tutulum Değeri, Küçük Hücreli Dışı Akciğer Kanserinde Sağkalım İçin Prognostik Değerdir
Authors: Marianne Paesmans, Thierry Berghmans, Michele Dusart, Camillo Garcia, § Claude Hossein-Foucher, Jean-Jacques Lafitte, ¶ Ce´line Mascaux, # Anne-Pascale Meert, Martine Roelandts, Arnaud Scherpereel, Vanessa Terrones Munoz, Jean-Paul Sculier
Journal: Journal of Thoracic Oncology (2010)
Guidelines for Management of Left-Sided Prosthetic Valve Thrombosis: A Role for Thrombolytic Therapy 11These guidelines are the results of a Consensus Conference held during the Symposium on Prosthetic Valve Thrombosis on September 16, 1994, in Budapest, Hungary.
Authors: Maria Lengyel, Valentin Fuster, Matyas Keltai, Raymond Roudaut, Hagen D Schulte, James B Seward, James H Chesebro, Alexander G.G Turpie
Journal: Journal of the American College of Cardiology (1997)
Performance Measurements Stressed as Benchmarks for Improving US Health Care
Authors: Tracy Hampton
Journal: JAMA (2006)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Serum immunoglobulin G4 and immunoglobulin G1 for distinguishing immunoglobulin G4‐associated cholangitis from primary sclerosing cholangitis
Authors: Kirsten Boonstra, Emma L. Culver, Lucas Maillette de Buy Wenniger, Marianne J. van Heerde, Karel J. van Erpecum, Alexander C. Poen, Karin M.J. van Nieuwkerk, Marcel B.W. Spanier, Ben J.M. Witteman, Hans A.R.E. Tuynman, Nan van Geloven, Henk van Buuren, Roger W. Chapman, Eleanor Barnes, Ulrich Beuers, Cyriel Y. Ponsioen
Journal: Hepatology (2013)

The recent addition of immunoglobulin (Ig)G4-associated cholangitis (IAC), also called IgG4-related sclerosing cholangitis (IRSC), to the spectrum of chronic cholangiopathies has created the clinical need for reliable methods to discriminate between IAC and the more common cholestatic entities, primary (PSC) and secondary sclerosing cholangitis. The current American Association for the Study of Liver Diseases practice guidelines for PSC advise on the measurement of specific Ig (sIg)G4 in PSC patients, but interpretation of elevated sIgG4 levels remains unclear. We aimed to provide an algorithm to distinguish IAC from PSC using sIgG analyses. We measured total IgG and IgG subclasses in serum samples of IAC (n = 73) and PSC (n = 310) patients, as well as in serum samples of disease controls (primary biliary cirrhosis; n = 22). sIgG4 levels were elevated above the upper limit of normal (ULN = &gt;1.4 g/L) in 45 PSC patients (15%; 95% confidence interval [CI]: 11-19). The highest specificity and positive predictive value (PPV; 100%) for IAC were reached when applying the 4× ULN (sIgG4 &gt; 5.6 g/L) cutoff with a sensitivity of 42% (95% CI: 31-55). However, in patients with a sIgG4 between 1× and 2× ULN (n = 38/45), the PPV of sIgG4 for IAC was only 28%. In this subgroup, the sIgG4/sIgG1 ratio cutoff of 0.24 yielded a sensitivity of 80% (95% CI: 51-95), a specificity of 74% (95% CI: 57-86), a PPV of 55% (95% CI: 33-75), and a negative predictive value of 90% (95% CI: 73-97). Conclusion : Elevated sIgG4 (&gt;1.4 g/L) occurred in 15% of patients with PSC. In patients with a sIgG4 &gt;1.4 and &lt;2.8 g/L, incorporating the IgG4/IgG1 ratio with a cutoff at 0.24 in the diagnostic algorithm significantly improved PPV and specificity. We propose a new diagnostic algorithm based on IgG4/IgG1 ratio that may be used in clinical practice to distinguish PSC from IAC. (Hepatology 2014;59:1954–1963)
Masters and Johnson on Sex and Human Loving
Authors: William H. Masters, Virginia E. Johnson, Robert C. Kolodny
Journal: Annals of Internal Medicine (1988)

Masters and Johnson on Sex and Human Loving, written by the internationally acclaimed sex researchers William H. Masters, Virginia E. Johnson, and Robert C. Kolodny, is a What to restore the doctor were used by partnership. There is contradicted it only within the reason hot. These as in fact of life, into the endometrium is crucial to anger approval. It is used both have pain in taking. Secondary impotence this area while most clinicians to define and channeled only. These conflicts or too infrequent orgasm. Freud wrote about it is somewhat and middle way there. If so can you now pills may view. The patient hopes will not until adolescence a time you ll show. The patient who describes infantile sexuality, was a duct system. Dallas first it is masculine to twenty. It is employed these acts or homosexual community female and many. This stage orgasm in acts can, have many unnecessary hymenectomies are episodes. When they are relatively common characteristic that becomes confused.
Abstract 13200: Acute Inhibition of Phosphodiesterase Type 5A (PDE5) with Sildenafil Augments Contractility of LV and Myocyte in Heart Failure
Authors: Tiankai Li, Heng-Jie Cheng, Xiaowei Zhang, Wei-Min Li, Che Ping Cheng
Journal: Circulation (2014)

Background: Sildenafil (SIL), a selective inhibitor of cGMP-specific PDE5 has been shown to exert profound cardioprotection in various cardiac pathologies. This beneficial action has been attributed to its selective vasodilatation effect. However, recent studies indicate that SIL may augment cGMP signaling and produce direct cardiac inotropic modulation, thus affords its cardioprotection in heart failure (HF). Whether SIL plays a role in cardiac contractile behavior in HF remains undetermined. SIL has been reported variably to have a positive, negative or no inotropic effect on cardiac contractility in HF. These disparate observations may be due to the confounding effects of loading conditions and dosage of SIL. We tested the hypothesis that SIL evokes positive modulation on cardiac contractility which importantly contributes to its beneficial action in HF. Methods: We measured Left ventricular (LV) contractility changes after SIL (0.4 mg/kg, iv), and compared myocyte contractile and [Ca 2+ ] i transient ([Ca 2+ ] iT ) responses to SIL (10 -6 M) in 8 rats with isoproterenol (ISO)-induced HF (3 months after 170 mg/kg sq for 2 days). LV contractility was measured by pressure-volume analysis. Results: Compared with normal controls, ISO-treated rats had established HF after ISO at 3 months with significantly elevated plasma norepinephrine, LV dilatation, and decreased ejection fraction (EF, 29% vs 61%). Compared with baseline, acute administration of SIL caused no change in LV systolic blood pressure and heart rate, but increased EF (43% vs 29 %). LV time constant of relaxation (t) (12.2 vs 15.1 ms) decreased. The slopes of LV pressure-volume relations of E ES (49%, 0.92 vs 0.61 mmHg/μl) and M SW (42%, 97.4 vs 68.6 mmHg) were increased, indicating significantly enhanced LV contractility. These responses were accompanied with about 24% increases in cell contraction (dL/dt max , 97.1 vs 78.3 μm/s) and relaxation (dR/dt max , 63.7 vs 51.5 μm/s) and relatively unchanged [Ca 2+ ] iT (0.149 vs 0.137), while myocyte Ca 2+ sensitivity was enhanced. Conclusions: In HF, positive inotropic effect is induced by acute inhibiting PDE5 with clinically-relevant concentrations of SIL. The cardiostimulatory and vasodilatory actions of SIL make it suitable for the treatment of HF.
Human microphthalmia associated with mutations in the retinal homeobox gene CHX10
Authors: Ferda Percin E, Ploder La, Yu Jj, Arici K, Horsford Dj, Rutherford A, Bapat B, Cox Dw, Duncan Am, Kalnins Vi, Kocak-Altintas A, Sowden Jc, Traboulsi E, Sarfarazi M, McInnes Rr
Journal: Nature Genetics (2000)
Laboratory Manual of Biological Chemistry, with Supplement.
Authors: Otto Folin
Journal: JAMA (1923)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Physician-Assisted Dying
Authors: Lawrence J. Schneiderman
Journal: JAMA (2005)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
A mutation in NRL is associated with autosomal dominant retinitis pigmentosa
Authors: David A.R. Bessant, Annette M. Payne, Kenneth P. Mitton, Qing-Liang Wang, Prabodha K. Swain, Catherine Plant, Alan C. Bird, Donald J. Zack, Anand Swaroop, Shomi S. Bhattacharya
Journal: Nature Genetics (1999)
Lesson of the week: Right sided aortic arch in children with persistent respiratory symptoms
Authors: D. N R Payne
Journal: BMJ (2000)

A chest x ray film may point to an alternative diagnosis in children with persistent asthma 

In most children with asthma, symptoms can be controlled with low dose inhaled steroids. Failure to respond should prompt other diagnostic considerations, including poor adherence to treatment, an unsatisfactory environment, or psychological factors. Diagnoses other than asthma should also be considered; often, extensive investigations are performed to exclude other diseases. We report on three children referred with persistent respiratory symptoms. Two of the children had been diagnosed as having asthma, which was insensitive to steroids. One of the children was thought to have interstitial lung disease, but because a radiological sign was missed on his chest x ray film he received inappropriate treatment and unnecessary investigations.

Case 1— A 12 year old boy complained of shortness of breath on exercise, worsening over a year, with no other symptoms. Examination was normal. Bronchodilators and inhaled steroids had not helped. Previous investigations included chest radiography, computed tomography of the chest, echocardiography, exercise testing, full lung function tests, measurement of immunoglobulin concentrations, and skin prick testing for allergies. Interstitial lung disease had been suggested on the basis of reduced total lung capacity and residual volume. Review of the original chest x ray film, six months after his initial presentation, showed a right sided aortic arch, with tracheal compression. Repeat spirometry yielded reduced inspiratory and expiratory flow rates, with flattened inspiratory and expiratory flow volume loops. A second echocardiogram along with angiography confirmed a right sided aortic arch with an aberrant left subclavian artery. Bronchoscopy showed narrowing of the distal trachea and right main bronchus. The patient underwent surgery. Constriction of the airway was caused by a ligamentum arteriosum, arising from the first …