Low-Molecular-Weight Heparin for Women With Unexplained Recurrent Pregnancy Loss
Authors: Rucha Patil, Kanjaksha Ghosh, Shrimati Shetty
Journal: Annals of Internal Medicine (2015)

Letters15 September 2015Low-Molecular-Weight Heparin for Women With Unexplained Recurrent Pregnancy LossRucha Patil, MSc, Kanjaksha Ghosh, MD, and Shrimati Shetty, PhDRucha Patil, MScFrom KEM Hospital, Mumbai, India.Search for more papers by this author, Kanjaksha Ghosh, MDFrom KEM Hospital, Mumbai, India.Search for more papers by this author, and Shrimati Shetty, PhDFrom KEM Hospital, Mumbai, India.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/L15-5137 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:We read Schleussner and colleagues' article (1) about the effect of low-molecular-weight-heparin (LMWH) on pregnancy outcomes in women with unexplained pregnancy loss with interest. On the basis of the absence of a significant difference in the live-birth rates between women who are and those who are not receiving anticoagulant therapy, the authors do not recommended anticoagulation in such women. A similar observation has been reported in a double-blind, placebo-controlled trial using enoxaparin (2). However, while applying the exclusion criteria for different acquired and inherited types of thrombophilia, one should consider the recently emerged prothrombotic marker—that is, cell-derived ...References1. Schleussner E, Kamin G, Seliger G, Rogenhofer N, Ebner S, Toth B, et al; ETHIG II group.. Low-molecular-weight heparin for women with unexplained recurrent pregnancy loss: a multicenter trial with a minimization randomization scheme. Ann Intern Med. 2015;162:601-9. [PMID: 25938990] doi:10.7326/M14-2062 LinkGoogle Scholar2. Pasquier E, de Saint Martin L, Bohec C, Chauleur C, Bretelle F, Marhic G, et al. Enoxaparin for prevention of unexplained recurrent miscarriage: a multicenter randomized double-blind placebo-controlled trial. Blood. 2015;125:2200-5. [PMID: 25636341] doi:10.1182/blood-2014-11-610857 CrossrefMedlineGoogle Scholar3. Patil R, Ghosh K, Satoskar P, Shetty S. Elevated procoagulant endothelial and tissue factor expressing microparticles in women with recurrent pregnancy loss. PLoS One. 2013;8:e81407. [PMID: 24278436] doi:10.1371/journal.pone.0081407 CrossrefMedlineGoogle Scholar4. Patil R, Ghosh K, Damania K, Bansal V, Satoskar P, Darekar A, et al. Effect of anticoagulant therapy on cell-derived microparticles and pregnancy outcome in women with pregnancy loss [Letter]. Br J Haematol. 2015. [PMID: 25921354] doi:10.1111/bjh.13460 CrossrefMedlineGoogle Scholar5. Zwicker JI, Liebman HA, Bauer KA, Caughey T, Campigotto F, Rosovsky R, et al. Prediction and prevention of thromboembolic events with enoxaparin in cancer patients with elevated tissue factor-bearing microparticles: a randomized-controlled phase II trial (the Microtec study). Br J Haematol. 2013;160:530-7. [PMID: 23240761] doi:10.1111/bjh.12163 CrossrefMedlineGoogle Scholar Author, Article, and Disclosure InformationAffiliations: From KEM Hospital, Mumbai, India.Disclosures: Authors have disclosed no conflicts of interest. Forms can be viewed at www.acponline.org/authors/icmje/ConflictOfInterestForms.do?msNum=L15-0355. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoLow-Molecular-Weight Heparin for Women With Unexplained Recurrent Pregnancy Loss Ekkehard Schleussner , Gabriele Kamin , Gregor Seliger , Nina Rogenhofer , Susanne Ebner , Bettina Toth , Michael Schenk , Melanie Henes , Michael K. Bohlmann , Thorsten Fischer , Oana Brosteanu , Rupert Bauersachs , David Petroff , and Low-Molecular-Weight Heparin for Women With Unexplained Recurrent Pregnancy Loss Elisabeth Pasquier and Luc de Saint Martin Low-Molecular-Weight Heparin for Women With Unexplained Recurrent Pregnancy Loss Ekkehard Schleussner and David Petroff Low-Molecular-Weight Heparin for Women With Unexplained Recurrent Pregnancy Loss Elisabeth Pasquier and Luc de Saint Martin Low-Molecular-Weight Heparin for Women With Unexplained Recurrent Pregnancy Loss Ekkehard Schleussner and David Petroff Metrics 15 September 2015Volume 163, Issue 6Page: 483-484KeywordsAnticoagulant therapyBlood plasmaClinical trialsConflicts of interestDisclosureLow molecular weight heparinPregnancy ePublished: 15 September 2015 Issue Published: 15 September 2015 Copyright & PermissionsCopyright © 2015 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...