JAUNDICE DURING METHIMAZOLE ("TAPAZOLE") ADMINISTRATION
Authors: J C SHIPP
Journal: Annals of Internal Medicine (1955)

Case Reports1 March 1955JAUNDICE DURING METHIMAZOLE ("TAPAZOLE") ADMINISTRATIONJOSEPH C. SHIPP, M.D.JOSEPH C. SHIPP, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-42-3-701 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptMethimazole, a highly effective antithyroid agent introduced by Stanley and Astwood1in 1949, is being used with increasing frequency in the treatment of hyperthyroidism. Toxic reactions have occurred in approximately 5% of over 200 reported cases.2, 3, 4, 5These include fever, skin rashes and bone marrow depression. Jaundice has been observed during the course of methimazole therapy. There have been few instances with adequate documentation of the histologic changes responsible for the alterations in hepatic function. Specht and Boehme6called attention to an obstruction-type jaundice associated with a fatal agranulocytic reaction which occurred one month after the initiation of...Bibliography1. StanleyAstwood MMEB: 1-Methyl-2-mercaptoimidazole: an antithyroid compound highly active in man, Endocrinology 44: 588 (June) 1949. CrossrefMedlineGoogle Scholar2. RevenoRosenbaum WSH: Treatment of hyperthyroidism with 1-methyl-2-mercaptoimidazole, J. A. M. A. 143: 1407 (Aug. 19) 1950. CrossrefMedlineGoogle Scholar3. TaylorTeitelbaumLarge NMA: Treatment of thyrotoxicosis with methimazole, Am. J. M. Sc. 222: 138 (Aug.) 1951. CrossrefMedlineGoogle Scholar4. HallmanBondy BLPK: Experience with methimazole in the treatment of hyperthyroidism, Am. J. Med. 11: 724 (Dec.) 1951. CrossrefMedlineGoogle Scholar5. Beierwaltes WH: 1-Methyl-2-mercaptoimidazole and 1-ethyl-2-mercaptoimidale: a clinical evaluation of two new antithyroid drugs, J. Lab. and Clin. Med. 36: 861 (Dec.) 1950. MedlineGoogle Scholar6. SpechtBoehme NE: Death due to agranulocytosis induced by methimazole therapy, J. A. M. A. 149: 1010 (July 12) 1952. CrossrefMedlineGoogle Scholar7. WernerHangerKritzler SCFMRA: Jaundice during methyl testosterone therapy, Am. J. Med. 8: 325 (Mar.) 1950. CrossrefMedlineGoogle Scholar8. GargillLesses SLMF: Toxic reactions to thiouracil, J. A. M. A. 127: 890 (Apr. 7) 1945. CrossrefGoogle Scholar9. HangerGutman FMAB: Post-arsphenamine jaundice apparently due to obstruction of intrahepatic biliary tract, J. A. M. A. 115: 263 (July 27) 1940. CrossrefGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: New York, N. Y.*Received for publication August 16, 1954.From the Department of Medicine, Columbia University College of Physicians and Surgeons, and the Presbyterian Hospital in the City of New York.†Present address: Department of Medicine, Harvard Medical School, Boston, Massachusetts. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byCarbonyl Traps as Potential Protective Agents against Methimazole-Induced Liver InjuryA case of Methimazole-Induced Cholestatic Jaundice With AgranulocytosisMethimazole-induced Cholestatic JaundiceMethimazole-induced cholestatic liver injury, mimicking sclerosing cholangitisHyperthyroïdie, methimazole et phosphatase alcalineAplastic Anemia Associated with Antithyroid DrugsThyroid Hormones and the LiverAgranulocytosis Associated with Antithyroid Drugs Effects of Patient Age and Drug DoseDAVID S. COOPER, M.D., DAVID GOLDMINZ, B.S., ANN A. LEVIN, M.S., PAUL W. LADENSON, M.D., GILBERT H. DANIELS, M.D., MARK E. MOLITCH, M.D., E. CHESTER RIDGWAY, M.D.Treatment of Hyper- and HypothyroidismHistological abnormalities of the avian liver resulting from dietary methimazoleIntrahepatic Cholestasis vs. Posthepatic Jaundice: Methods of Diagnosis: With a Note on Hypercholesteremic Xanthomatosis in a Patient with Chlorpromazine CholestasisCLINICAL AND LABORATORY MANIFESTATIONS OF HEPATOTOXICITYDrug-Induced Hepatic Injury During Methimazole TherapyAllergic Hepatitis Caused by Propionyl Erythromycin Ester of Lauryl SulfateDrug-Induced JaundiceAcute Intrahepatic CholestasisIntrahepatic cholestasis following administration of chlorpropamideJAUNDICE ASSOCIATED WITH NORETHANDROLONE (NILEVAR) THERAPY*RICHARD K. SHAW, M.D., G. LENNARD GOLD, M.D.DRUG-INDUCED HEPATIC INJURY*HANS POPPER, M.D., F.A.C.P., FENTON SCHAFFNER, M.D., F.A.C.P.Cholestasis produced by the administration of norethandroloneIntrahepatic cholestasisGelbsucht mit Verschlusssyndrom aus nichtmechanischer UrsacheDrug reactions characterized by cholestasis associated with intrahepatic biliary tract obstructionThyreostatika 1 March 1955Volume 42, Issue 3Page: 701-706KeywordsBone marrowDrugsFeversHospital medicineHyperthyroidismRashesSurgeons Issue Published: 1 March 1955 PDF downloadLoading ...