Cefuroxime Dosage in Renal Failure
Authors: Thomas G. Cantu
Journal: Annals of Internal Medicine (1988)

Letters and Corrections15 December 1988Cefuroxime Dosage in Renal FailureThomas G. Cantu, PharmD, David Fantozzi, RPhThomas G. Cantu, PharmDSearch for more papers by this author, David Fantozzi, RPhSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-109-12-989_2 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the Editor: Drug Prescribing in Renal Failure by Bennett and colleagues (1) possibly contains a misprint. This excellent reference provides dosage recommendations for various drugs when prescribed for patients with differing degrees of renal dysfunction.For patients with an estimated glomerular filtration rate of less than 10 mL/min, Bennett and colleagues recommend 5%-10% of the usual intravenous cefuroxime dosage. If the usual dose of 750 mg is given every 8 hours, patients will receive 112 to 225 mg daily. Ten percent of the dosage for life-threatening infections (1.5 g every 6 hours) provides 600 mg daily. In contrast, the...References1. Bennett W, Aronoff G, Golper T, Morrison G, Singer I, and Brater D. Drug Prescribing in Renal Failure: Dosing Guidelines for Adults. Philadelphia: American College of Physicians; 1987. Google Scholar2. Glaxo. Zincef. In: Physician's Desk Reference. Oradell, New Jersey: Medical Economics Company, Inc.; 1988. Google Scholar3. Chan M, Browning A, Poole C, Matheson L, Li C, and Baillod R. Cefuroxime pharmacokinetics in continuous and intermittent peritoneal dialysis. Nephron. 1985;41:161-5. CrossrefMedlineGoogle Scholar4. Walstad R, Nilsen O, and Berg K. Pharmacokinetics and clinical effects of cefuroxime in patients with severe renal insufficiency. Eur J Clin Pharmacol. 1983;24:391-8. CrossrefMedlineGoogle Scholar1. Bennett W, Aronoff G, Golper T, Morrison G, Singer I, and Brater D. Drug Prescribing in Renal Failure: Dosing Guidelines for Adults. Philadelphia: American College of Physicians; 1987. Google Scholar2. Walstad R, Nilsen O, and Berg K. Pharmacokinetics and clinical effects of cefuroxime in patients with severe renal insufficiency. Eur J Clin Pharmacol. 1983;24:391-8. CrossrefMedlineGoogle Scholar3. Buntzen R, Toothaker R, Nielson O, Madsen P, Welling P, and Craig W. Pharmacokinetics of cefuroxime in normal and impaired renal function: comparison of high pressure liquid chromatography and microbiological assays. Antimicrob Agents Chemother. 1981;19:443-9. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: Thomas G. Cantu, PharmD; David Fantozzi, RPhAffiliations: Johns Hopkins Hospital Baltimore, MD 21205 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byBeneficial Antimicrobial Effect of the Addition of an Aminoglycoside to a β-Lactam Antibiotic in an E. coli Porcine Intensive Care Severe Sepsis Model 15 December 1988Volume 109, Issue 12Page: 989-990KeywordsDrugsEstimated glomerular filtration rateRenal failure ePublished: 1 December 2008 Issue Published: 15 December 1988 PDF downloadLoading ...