tbuckley/cabot-search huggingface dataset:
Computerized Analysis of Holter Monitor Tapes
Authors: WILLIAM FOX
Journal: Annals of Internal Medicine (1985)

Letters and Corrections1 May 1985Computerized Analysis of Holter Monitor TapesWILLIAM FOX, M.D., DAVID J. KACZKOWSKI, R.C.T.WILLIAM FOX, M.D.Search for more papers by this author, DAVID J. KACZKOWSKI, R.C.T.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-102-5-716_2 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: We write to address the issue of computerized analysis of Holter monitor tapes as discussed by Morganroth (1). We believe strongly, and our experience reinforces our belief, that these computerized systems pose a great danger to patient care that is based on their analysis of Holter tapes. All manufacturers claim high accuracy for their detection devices, and this claim is often taken as truth, with the result that much computer-generated data are not checked. We fully agree with Morganroth that all systems should undergo rigorous quality control, using manually analyzed tapes with known data. Is this not...Reference1. MORGANROTH J. Ambulatory Holter electrocardiography: choice of technologies and clinical uses. Ann Intern Med. 1985;102:73-81. LinkGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Illinois Cardiodynamics, Incorporated Berwyn, IL 60402 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 May 1985Volume 102, Issue 5Page: 716-717KeywordsComputersComputing systemsPatientsQuality improvement Issue Published: 1 May 1985 PDF DownloadLoading ...
The reality of a universal language faculty
Authors: Steven Pinker, Ray Jackendoff
Journal: Behavioral and Brain Sciences (2009)

Abstract While endorsing Evans &amp; Levinson's (E&amp;L's) call for rigorous documentation of variation, we defend the idea of Universal Grammar as a toolkit of language acquisition mechanisms. The authors exaggerate diversity by ignoring the space of conceivable but nonexistent languages, trivializing major design universals, conflating quantitative with qualitative variation, and assuming that the utility of a linguistic feature suffices to explain how children acquire it.
Seeking Scientific Acceptance of In Vitro Tests
Authors: Charles Marwick
Journal: JAMA (1989)

MODERN-DAY TOXICOLOGY is going under glass. Simultaneously with pressures from groups concerned about what they believe is unnecessary use of animals in tests, considerable scientific interest is developing in using in vitro techniques to evaluate the safety of commercial products, such as certain compounds or drugs. However, despite the fact that in recent years a number of in vitro tests have been developed to replace tests on animals, a broad science base using in vitro technologies has yet to be developed. Alan M. Goldberg, PhD, of the School of Hygiene and Public Health says that, with an $800 000 research program spread among 12 to 15 institutions around the country as well as Hopkins itself, he and his associates are seeking to lay the groundwork for scientific acceptability of in vitro testing. "There are those who think that the methodologies already exist to do this," he says. "But this is
47. Ex Vivo Hypothermic Recirculatory Adenoviral Gene Transfer to the Transplanted Pig Heart
Authors: Keiji Oi, William R. Davies, Henry D. Tazelaar, Kent R. Bailey, Mark J. Federspiel, Stephen J. Russell, Christopher G.A. McGregor
Journal: Molecular Therapy (2005)

Background: Heart transplantation is the most efficient and successful therapeutic procedure for end stage heart failure, but several limitations such as primary graft failure, acute graft rejection and chronic allograft vasculopathy still remain to be overcome. To facilitate the application of adenoviral gene therapy in clinical heart transplantation, we developed an ex vivo hypothermic recirculatory adenoviral gene transfer method to the transplanted pig heart.
Identification of CD16/NKH-1+ natural killer cells and their relevance to cutaneous tumour immunity
Authors: A.C. MARKEY, D.M. MACDONALD
Journal: British Journal of Dermatology (1989)

The presence of natural killer (NK) cells, as defined by reactivity with the monoclonal antibodies Leu 7, Leu 11 and Leu 19 was assessed in the inflammatory infiltrate around epidermal neoplasms and compared with findings in a range of inflammatory dermatoses. HNK-1+ (Leu 7) cells were present in a wide range of malignant, pre-malignant and inflammatory disorders. Cells positive for the more specific NK cell antigens CD16 (Leu 11)/NKH-1 (Leu 19) had a distribution mainly restricted to cases of squamous cell carcinoma (five of nine) and keratacanthoma (three of seven). The variability in distribution between the different antibodies suggests that the majority of cutaneous HNK-1+ cells are not NK cells, but represent cross-reacting T lymphocytes. The qualitatively distinct distribution of CD16+ and NKH-1+ cells around some cases of squamous cell carcinoma and keratoacanthoma is of interest but their absence from a number of such cases calls into question a specific effector role for natural killer cells in these squamoproliferative tumours.
Abstract A3: Facilitating epithelial to mesenchymal transition through inhibition of senescence checkpoint functions
Authors: Shinya Ohashi, Mitsuteru Natsuizaka, Gabrielle Wong, Katharine D. Grugan, Jiri Kalabis, Anil K. Rustgi, Hiroshi Nakagawa
Journal: Cancer Research (2009)

Abstract Transforming growth factor (TGF)-β is a potent inducer of epithelial to mesenchymal transition (EMT). However, EMT is not a sole consequence of TGF-β mediated stimulation. It remains unclear as to what determines the underlying cellular capacity to undergo EMT in response to TGF-β. Overexpression of epidermal growth factor receptor (EGFR) and mutations in tumor suppressor p53 are common in the early stage of esophageal carcinogenesis and required for transformation and invasive growth of human esophageal epithelial cells. EGFR overexpression and mutant p53 appear to be key determinants in facilitating TGF-β-induced EMT. EGFR tyrosine kinase activity was dispensable for EMT. However, EGFR overexpression fated the esophageal cells to EMT through induction of ZEB1 and ZEB2, zinc finger E-box binding proteins which evade EGFR-mediated oncogenic as well as the TGF-β-activated senescence responses by inhibiting p15INK4b and p16INK4a. Mutant p53 limits TGF-β-induced senescence by suppressing the p53-dependent senescence checkpoint function. When senescence was negated, TGF-β prompted EMT through induction of ZEB1 and ZEB2 along with concomitant downregulation of the microRNA-200 family. Thus, genetic lesions may involve not only suppression of senescence checkpoint functions but also reactivation of the cellular EMT program in the early stages of carcinogenesis. Citation Information: Cancer Res 2009;69(23 Suppl):A3.
Adverse events reporting in English hospital statistics: Data relevant to patient safety should not be presented alone and out of context
Authors: Richard Thomson
Journal: BMJ (2004)

EDITOR—The publication of Dr Foster's case notes has generated considerable interest,1 but accurately quantifying patient safety incidents is difficult. Methods of intensive case note review provide estimates of adverse events in acute hospitals that range from 2.9% to 16.6%, but definitions, methods, and health systems vary.2 3

The National …
Measurement of gastric emptying by real-time ultrasound.
Authors: D N Bateman, T A Whittingham
Journal: Gut (1982)

A safe non-invasive technique for the measurement of gastric volume by real-time ultrasound is described. The application of this technique to the measurement of the emptying of liquid from the stomach is outlined. Gastric emptying of liquid was found to be log-linear, the mean half-life of emptying in 10 volunteers being 22 . 0 +/- 2 . 5 min. Ultrasound measurement of gastric emptying provides an opportunity to study the effects of drugs and disease on gastric motor function in man.
A Note on Statistical Usage
Authors: David M. Engelhardt
Journal: JAMA (1961)

<h3>To the Editor:—</h3> In reply to your letter of July 21, I have now had an opportunity to discuss Dr. Hawkins' paper with my associate, Dr. Norbert Freedman. Dr. Hawkins is correct in pointing out an ambiguity in the interpretation of our data (Englehardt and others: Prevention of Psychiatric Hospitalization with Use of Psychopharmacological Agents,<i>JAMA</i><b>173</b>:147-149 [May 14] 1960). Chlorpromazine and promazine are not homogeneous in their treatment effects, insofar as we assessed their treatment effects. The data do not warrant a conclusion regarding a<i>combined</i>chemotherapeutic effect, and no such interpretation was intended by us even though the paper might have created this impression. These considerations do not invalidate our major conclusion. The Table in our paper giving frequencies for 3 treatment conditions and 2 types of outcome showed a non-chance association. Type of treatment was a significant source of variation affecting treatment outcome. Inspection of the
Further update on leptospirosis: continuing risk in fish farmers.
Authors: N Gill, S A Waitkins, I M Calder
Journal: BMJ (1985)

others it was the exception rather than the rule for the general practitioner to be present.In order for the general practitioner to be present there must be cooperation between both doctors, who will both have busy schedules.As stated in the original article, the purpose of the service is not only to provide treatment or advice but also to aid the joint consultation between the consultant and the general practitioner.It would seem that this is not occurring in most consultations in the Trent region.
Probiotics and prebiotic galacto-oligosaccharides in the prevention of allergic diseases: A randomized, double-blind, placebo-controlled trial
Authors: Kaarina Kukkonen, Erkki Savilahti, Tari Haahtela, Kaisu Juntunen-Backman, Riitta Korpela, Tuija Poussa, Tuula Tuure, Mikael Kuitunen
Journal: Journal of Allergy and Clinical Immunology (2006)
Vaccination with pre-diagnostic tumor antigens but not established tumor antigens inhibits spontaneous tumorigenesis in TgMMTV-neu mice
Authors: Sasha E Stanton, Jianning Mao, John Ladd, Lauren Rastedder, Ekram Gad, Samir Hanash, Hailing Lu, Mary L Disis
Journal: Journal for ImmunoTherapy of Cancer (2013)

Meeting abstracts Breast cancer is immunogenic and proteins expressed in breast cancer stimulate both an antibody and a T-cell immune response. Cancer related proteins that are aberrant enough to trigger early immune recognition might be ideal targets for a vaccine aimed at preventing the
Five years of complete remission of gastric diffuse large B cell lymphoma after eradication of Helicobacter pylori infection
Authors: M M Alsolaiman, G Bakis, T Nazeer, R P MacDermott, J A Balint
Journal: Gut (2003)

Long term follow up data are not available for cases of diffuse large B cell gastric lymphoma treated by eradicating <i>Helicobacter pylori</i> alone. We present the case of an 82 year old man with diffuse large B cell lymphoma localised to the stomach which responded to <i>H pylori</i> eradication and which has not recurred after more than five years of close follow up. Our patient was not a candidate for other modalities of treatment. This case demonstrates that the option of treating <i>H pylori</i> infection as the initial trial of treatment for localised diffuse large B cell lymphoma is appropriate for consideration. If medical therapy using eradication of <i>H pylori</i> is used, it is essential that the patient undergoes close observation and repeated surveillance endoscopies.
Clinical Topics in Internal Medicine
Authors: Roberta A. Monson
Journal: JAMA (1982)

As the title implies, this small text explores selected topics in various disciplines of medicine. Certain chapters, such as "Current Status of the Exercise ECG" and "Radionuclide Techniques in the Diagnosis of Coronary Heart Disease," provide the reader with explicit information on the sensitivity and specificity of the tests in various settings as well as current recommendations on appropriate use of these important diagnostic tools. Other chapters, such as those on inhalation therapy, asthma, and topical steroids, focus more on therapeutics. Laboratory studies for the evaluation of thyroid diseases and rheumatologic disorders are dealt with in detail in separate well-written chapters. A more standard descriptive classification approach is used to discuss non-Hodgkin's lymphoma, glomerulonephridites, and hyperlipidemias. The latter chapter was disappointing in its failure to address critically the issue of long-term effectiveness of available treatment modalities in preventing morbidity and mortality and to make more justifiable recommendations on the population
Referred Pains from Muscle
Authors: J. H. Kellgren
Journal: BMJ (1938)

Pain of both kcinds is conveyed by the antero-lateral tract, as is shown by the abolition of both in cases in which this tract has been divided surgically.periosteum and joints are often associated, as are for the most part those from the viscera, with quiescence, with slowing of the pulse, a fall of blood pressure, and nausea, the last phenomenon being responsible for the common designation " sickening " which is applied to this but never to cutaneous pain.
Does sodium restriction lower blood pressure?
Authors: D Simmons
Journal: BMJ (1986)

2500 in Sweden, 3900 in the UK, and 4000 in France to 11155 in West Germany and 12000 in the USA.Since the markets of the developed world do not collectively appear to support such enormous numbers of products, it is surprising that such numbers whichare claimed to exist in hird World markets are attributed to exports from the Western world.J P GRMIN ABPI, London SWIA 2DY Does sodium restriction lower blood pressure?SIR,-Dr M R Lee and colleagues (26 July, p 266) suggest that hypertension in blacks is different from that in white people and may be more salt dependent.In rural Belize the Creoles, an Afro- Caribbean group, certainly had higher blood pres- sures than either an Amerindian (Mayan) or Amerindian-European (Mestizzo) group.'How- ever, when Creoles were compared with rural and urban Malawians (central Africans) studied using the same epidemiological techniques2 the urban Africans had the highest blood pressures.This was in spite of the urban Africans being younger, lighter and less obese and having a lower output of overnight urinary sodium than the Creoles (table ).Obviously factors other than salt intake have caused these differences and, they may not all be environmental.It may be that genetic differences between Afio-Caribbean communities are as im- portant as those between whites and blacks, and Mean blood pressres, ages, weight, body mass indx, and overnght winary sodium osuput Creoles Urban Malawians Rural Malawians Men Women Men Women Men Women Blood pressure (mm Hg) 124/66-6 115/65-4 127-5*/76-2
LTP plays a distinct role in various brain structures
Authors: Ken-ichi Hara, Tatsuo Kitajima
Journal: Behavioral and Brain Sciences (1997)

LTP is thought to be an experimental model for studying the cellular mechanism of learning and memory. Shors &amp; Matzel review some contradictory data concerning the linkage between LTP and memory and suggest that LTP does not underlie learning and memory. LTP is a cellular and synaptic process and cannot be a memory mechanism. In fact, it is a cellular information storage mechanism.
Consultation-liaison scheme for self-poisoned patients in a general hospital.
Authors: R Gardner, R Hanka, B Evison, P M Mountford, V C O'Brien, S J Roberts
Journal: BMJ (1978)

In a prospective clinical trial 276 self-poisoned patients consecutively admitted to hospital were randomly allocated to medical teams or to psychiatrists for an initial psychiatric assessment and a decision about "disposal." Junior doctors and nurses received instruction in this work. While awaiting the outcome of the trial the randomisation was continued for 13 months and 729 allocations were made altogether. Physicians requested psychiatric opinions for roughly one in five of their patients. In other respects medical teams performed similarly to psychiatrists. Provided that due attention is given to teaching junior staff and to ensuring that psychiatric treatment and social-work support are available once patients have been assessed, such a consultation-liaison scheme could be adopted in other hospitals. This would help to change unfavourable attitudes towards self-poisoned patients and contribute to the general training of doctors and nurses.
Treatment of Fractures and Dislocations of the Cervical Spine, Complicated by Cervical-Cord and Root Injuries
Authors: Donald Munro
Journal: New England Journal of Medicine (1961)

IN 1939 Wegner and I1 and again in 1943 I2 made the statement that "Every discussion of any level of any spinal cord injury should be based on two fundamental concepts. These are that spinal cord injuries are different from spinal column injuries without spinal cord involvement, and that all significant spinal cord injuries are accompanied by spinal shock and its effects." This was on the basis of experience with 101 cervical-cord injuries. Now, sixteen years later and with my experience with such injuries more than tripled, this statement can be reaffirmed without the change of a word.The implications . . .
Mutation of a nuclear receptor gene, NR2E3, causes enhanced S cone syndrome, a disorder of retinal cell fate
Authors: Neena B. Haider, Samuel G. Jacobson, Artur V. Cideciyan, Ruth Swiderski, Luan M. Streb, Charles Searby, Gretel Beck, Robin Hockey, David B. Hanna, Susan Gorman, David Duhl, Rivka Carmi, Jean Bennett, Richard G. Weleber, Gerald A. Fishman, Alan F. Wright, Edwin M. Stone, Val C. Sheffield
Journal: Nature Genetics (2000)
Targeting allergen to FcγRI reveals a novel TH2 regulatory pathway linked to thymic stromal lymphopoietin receptor
Authors: Kathryn E. Hulse, Amanda J. Reefer, Victor H. Engelhard, James T. Patrie, Steven F. Ziegler, Martin D. Chapman, Judith A. Woodfolk
Journal: Journal of Allergy and Clinical Immunology (2010)
Systemic lupus erythematosus and nephritis: severe relapse with disappearance of antinuclear antibodies.
Authors: N J White, C G Winearls, J G Ledingham
Journal: BMJ (1980)

deposition of C3 in perilesional skin.These appearances were-consistent with pemphigus erythematosus.The HLA genotype was HLA-A1, 3/8, 18/BL, -/-/6/DRW3, DRW5.
Reverberations of Hebbian thinking
Authors: Josef P. Rauschecker
Journal: Behavioral and Brain Sciences (1995)

Abstract Cortical reverberations may induce synaptic changes that underlie developmental plasticity as well as long-term memory. They may be especially important for the consolidation of synaptic changes. Reverberations in cortical networks should have particular significance during development, when large numbers of new representations are formed. This includes the formation of representations across different sensory modalities.
Racial and Social Factors in Systemic Lupus Erythematosus
Authors: Morris Siegel
Journal: JAMA (1965)

An epidemiologic study of systemic lupus erythematosus in a defined area of New York revealed significant racial differences in susceptibility. Morbidity and mortality rates were highest among Negroes residing in the area studied, followed in descending order by the rates for Puerto Ricans and then other whites. Confirmatory data were obtained on a city-wide basis from reported deaths and on a national level from discharged patients of Veterans Administration hospitals. The racial differences observed in New York were independent of poor housing, overcrowding, and migration. They were associated with racial differences in γ-globulin levels of normal individuals.
NECESSITY OF CONSENT TO OPERATIONS
Authors: W. S. WERMUTH
Journal: JAMA (1913)

After the urine becomes normal, I reduce the number of tablets to four or six a day, and give these three weeks out of each month.Whether this is absolutely necessary, or not, I am not quite prepared to say.Most of my early patients have not continued with the treat- ment in this way.and have remained well.If the high blood-pressure persists, I follow the thyroid treatment with the persistent use of potassium iodid and nitro- glycerin, as mentioned in my previous paper, 1 do this because, clinically, 1 am quite certain that it has done my patients, with this condition, much good.I am con- vinced that the administration of the dried thyroid gland in addition to offering a method of efficient treat- ment to the internist, offers to the surgeon, as well, a means of benefiting his operative cases when nephritis, mild or severe, is one of his problems.
Abstract 3149: Genetic alteration of lung adenocarcinomas with micropapillary component.
Authors: Masashi Furukawa, Shinichi Toyooka, Hiromasa Yamamoto, Ryuhei Tada, Shinsuke Hashida, Kazuhiko Shien, Junichi Soh, Hiroaki Asano, Kazunori Tsukuda, Mamoru Ouchida, Kouichi Ichimura, Shinichiro Miyoshi
Journal: Cancer Research (2013)

Abstract Purpose: Adenocarcinoma with micropapillary component (AMPC) is known as one of aggressive subtypes among lung adenocarcinoma. The molecular profiles of AMPC have not been well characterized from the view point of difference from other adenocarcinomas. In this study, we analyzed molecular alterations of AMPC to investigate its molecular pathogenesis. Methods: We reviewed pathological reports of patients who underwent surgical resection for lung cancers between April 2004 and May 2012. Twenty-eight patients were recorded to possess micropapillary component among 674 patients diagnosed as lung adenocarcinoma. A total of 52 resected lung adenocarcinomas without micropapillary component were selected in the same period so as to adjust age, sex, and smoking status to those of the patients with micropapillary component. Mutational status was determined by the following two methods: SNaPshot assay based on multiplex PCR, primer extension, and capillary electrophoresis that was designed to assess for 38 somatic mutations in eight genes (AKT1, BRAF, EGFR, KRAS, MEK1, NRAS, PIK3CA, and PTEN), and a PCR-based sizing assay that assesses for EGFR exon 19 deletions, EGFR exon 20 insertions, and HER2 exon 20 insertions. EML4-ALK fusion was screened by ALK immunohistochemistry and confirmed using reverse transcriptional PCR assay and break-apart FISH assay.Results: As for genetic alterations, 13 (46.4%) of 28 lung adenocarcinomas with micropapillary component harbored mutually exclusive mutations: 9 (32.1%) EGFR mutation, 1 (3.3%) KRAS mutation and 3 (9.9%) EML4-ALK fusion. Adenocarcinomas without micropapillary component harbored 11 (21.2%) EGFR mutations and 8 (15.3%) KRAS mutations in a mutually exclusive manner, but had no EML4-ALK fusion genes. There were no mutations in AKT1, BRAF, EGFR, KRAS, MEK1, NRAS, PIK3CA, PTEN and HER2 genes in the both groups. EML4-ALK fusions appeared to occur significantly more frequent in AMPC than in control cases (P = 0.039).Conclusion: Although the size of our study was small, our study suggests the molecular pathogenesis of AMPC may be different from other adenocarcinoma, associated with its unique character among lung adenocarcinomas. Citation Format: Masashi Furukawa, Shinichi Toyooka, Hiromasa Yamamoto, Ryuhei Tada, Shinsuke Hashida, Kazuhiko Shien, Junichi Soh, Hiroaki Asano, Kazunori Tsukuda, Mamoru Ouchida, Kouichi Ichimura, Shinichiro Miyoshi. Genetic alteration of lung adenocarcinomas with micropapillary component. [abstract]. In: Proceedings of the 104th Annual Meeting of the American Association for Cancer Research; 2013 Apr 6-10; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2013;73(8 Suppl):Abstract nr 3149. doi:10.1158/1538-7445.AM2013-3149