tbuckley/cabot-search huggingface dataset:
Bacterial endocarditis in subjects 60 years of age and older.
Authors: R Thell, F H Martin, J E Edwards
Journal: Circulation (1975)

Forty-two cases of bacterial endocarditis with pathologic confirmation are reviewed. Infection was restricted to one or both left-sided valves in 31 cases, right-sided valves in five cases, and valves in both sides of the heart in six cases. In those specimens available for review, underlying valvular disease was identifiable in 24 of 38 cases (63%). The common underlying diseases, in order of decreasing frequency, were calcified or otherwise deformed aortic valves (11 cases) and rheumatic fibrosis of the mitral valve (eight cases). The floppy mitral valve was the underlying condition in two cases and amyloid infiltration of the tricuspid valve in one. Among the 34 cases from which a specific organism was identified, the dominant organisms were Staphylococcus (14 cases) and various types of Streptococci(ten cases). Fungi were the causative organisms in two cases. The clinical suspicion for the presence of bacterial endocarditis was low (40% of 40 cases with adequate data). In those cases with adequate data, murmurs were present in 68% and fever in 93%. Of those patients with fever, clinical diagnosis was made or suspected in only 38%. When a murmur was present, the clinical diagnosis was made or suspected in 54% of the cases, while when a murmur was absent the disease was suspected in only 9% of the cases. The clinical diagnosis of bacterial endocarditis in older subjects depends upon 1) knowledge that the disease may occur in such subjects and 2) recognition that, although fever is commonly present, murmurs may be absent.
Characterisation of human articular cartilage link proteins from normal and osteoarthritic cartilage: a comment.
Authors: D W Bullimore
Journal: Annals of the Rheumatic Diseases (1982)

Characterisation of human articular cartilage link proteins from normal and osteoarthritic cartilage: a comment SIR, Ryu et al.' studied the ability of human articular carti- lage link proteins to stabilise the interaction between proteoglycan subunit (from bovine tracheal cartilage) and high -V0
Exercise tests in large groups of children are not a suitable screening procedure for undiagnosed asthma
Authors: H. Johansson, T. Foucard, L.‐G. Pettersson
Journal: Allergy (1997)

Schoolchildren ( n = 473), 12–13 years of age, from five schools, and without known asthma, participated in a screening test for exercise‐induced asthma (E1A). The children were tested in large groups of 10–15 pupils. Peak expiratory flow (PEF) was measured before, immediately after, and 6–8 min after 6 min of running exercises in a gymnasium. A fall in PEF of at least 10% on two separate test occasions was considered an abnormal result. Children with abnormal results were given an asthma questionnaire and then tested individually in hospital with a standardized exercise test measuring FEVb PEF, and flow/volume curve. In the screening test, 23 (4.9%) of the 473 children had an abnormal result. When tested in hospital, five (1%) children had a decrease in PEF and/or FEV, of at least 10% (10–14%) after exercise. Furthermore, three of these five children had a history indicating mild EIA. We conclude that the use of PEF measurement as a screening method for EIA in large groups of schoolchildren cannot be recommended because it yields many false‐positive results.
The atherogenic effects of chlamydia are dependent on serum cholesterol and specific to Chlamydia pneumoniae
Authors: He Hu, Grant N. Pierce, Guangming Zhong
Journal: Journal of Clinical Investigation (1999)

Epidemiological investigations have linked Chlamydia pneumoniae infection to atherosclerosis. It is not clear, however, whether C. pneumoniae infection plays a causal role in the development of atherosclerosis. Mice with low-density lipoprotein receptor deficiency were induced to develop atherosclerotic lesions in aorta with a cholesterol-enriched diet that increased serum cholesterol by two- to threefold. Using this mouse model, we found that the chlamydial infection alone with either the C. pneumoniae AR39 or the C. trachomatis MoPn strain failed to induce any significant atherosclerotic lesions in aorta over a period of nine months. However, in the presence of a high-cholesterol diet, infection with the C. pneumoniae AR39 strain significantly exacerbated the hypercholesterolemia-induced atherosclerosis, demonstrating that a hypercholesterolemic condition is required for the C. pneumoniae to aggravate the development of atherosclerosis. Although both AR39 and MoPn antigens were detected in aorta of mice infected with the corresponding strains, only mice infected with the C. pneumoniae strain AR39 displayed enhanced atherosclerotic lesions, suggesting that the C. pneumoniae species may possess a unique atherogenic property. This study may provide a model for further understanding the mechanisms of C. pneumoniae atherogenesis and evaluating chlamydial intervention strategies for preventing the advancement of atherosclerotic lesions enhanced by C. pneumoniae infection.
Formaldehyde sterilization for dialysers.
Authors: M Murray, J R Dathan, F J Goodwin
Journal: BMJ (1969)

BpRITISHAL 235 mal in the first four hours after delivery of the infant; the level declines thereafter and at 24 hours is the same as or a little higher than that seen in late pregnancy and at the onset of labour.The level of F.D.P. is even higher in 50% of women with twin births.We have not made any observations later than 24 hours after delivery.Recent findings' regarding the haemagglu- tination inhibition assay have shown that the assay can be considerably simplified by the substitution of human for sheep red cells.A uniform level of protein for dilution of samples and standards should be used throughout the assay to achieve reliable results.We have largely abandoned the use of the microtitre (or similar) system, since we found that it introduces a consistent error, as it tends to produce less than doubling dilutions, resulting in fallaciously low readings.In addition, the currently used assay which in- volves red cell agglutination (rather than a settling pattern of cells) is easier to read in a plate with larger wells.We have been able to adapt the method to the AutoAnalyzer with similar and even more reproducible results, allowing more certain detection of small differences between samples.Recheck- ing our previous results on the AutoAnalyzer has confirmed the results mentioned above.-We are, etc.,
Reply to Shiu-Dong Chung, Hong-Jeng Yu and Shih-Chieh Chueh's Letter to the Editor re: Ching-Chia Li, Tu-Hao Chang, Wen-Jeng Wu, et al. Significant Predictive Factors for Prognosis of Primary Upper Urinary Tract Cancer after Radical Nephroureterectomy in Taiwanese Patients. Eur Urol 2008;54:1127–35
Authors: Wen-Jeng Wu
Journal: European Urology (2008)
Dyspnoea persisting after surgery for a vascular ring
Authors: AO Bron, EA Mensen, JH Dijkman, HA Huysmans, R Aalbers
Journal: European Respiratory Journal (1994)

We present the case of a 25 year old woman who, 3 yrs after resection of a vascular ring, had persisting complaints of episodic dyspnoea. This was caused by compression of the distal trachea and ostium of the right main bronchus by the descending part of the remaining right-sided aorta. Probable mechanisms are discussed.
Dose-effects of 8-methoxypsoralen and UVA in cultured human lymphocytes
Authors: J. P. KRUGER, E. CHRISTOPHERS, M. SCHLAAK
Journal: British Journal of Dermatology (1978)

Cultures of human lymphocytes were incubated with 8-methoxypsoralen (8-MOP) and irradiated with long wave ultraviolet light (UVA). Subsequently the mitogenic response to PHA was determined by 3H-thymidine incorporation. The minimal effective dosages of drug and light for the partial suppression of lymphocyte PHA-responsiveness were found to be 0.1 microgram/ml 8-MOP and 0.5 J/cm2 UVA. While an increase in the concentration of 8-MOP revealed a comparatively small rise in phototoxicity, a marked inhibition of 3H-thymidine uptake was obtained by increasing the UVA dosage. Cell viability of non-stimulated lymphocytes was similarly affected by the combined treatment.
Myxedema Coma Induced by Ingestion of Raw Bok Choy
Authors: Michael Chu, Terry F. Seltzer
Journal: New England Journal of Medicine (2010)

To the Editor: An 88-year-old Chinese woman was brought to the emergency department by her family, who reported that she had been lethargic and unable to walk or swallow for 3 days. She had been eating an estimated 1.0 to 1.5 kg of raw bok choy daily for several months in the belief that it would help control her diabetes. She had no previous history of thyroid disease. On examination the patient was lethargic. The temperature was 36.1°C, the pulse 58 beats per minute, blood pressure 181/89 mm Hg, and the respiratory rate 22 breaths per minute. A pulse oximetry . . .
Example of Prepublication Data Release: Immunoglobulin for Concomitant Infections
Authors: Charles Marwick
Journal: JAMA (1991)

INTRAVENOUS injection of a broad-spectrum immunoglobulin significantly reduces the number of bacterial infections in some children who are infected with the human immunodeficiency virus (HIV). It also significantly increases the time patients are free of infection and reduces the number of hospitalizations. These are the results of a double-blind, placebo-controlled study by the National Institute of Child Health and Human Development, Bethesda, Md. However, despite these findings, there was no effect on mortality. Thirty-one patients died in each of the two groups studied. The treatment is not a cure for pediatric acquired immunodeficiency syndrome (AIDS). The institute's parent, the National Institutes of Health, released the results prior to publication in a scientific journal, says the acting director, William Raub, PhD, in accordance with a proposed new system. (Please see related article on page 949.) "We believe these results have the prospect for an immediate and positive effect on the treatment
Essentials of Bedside Cardiology: For Students and House Staff
Authors: Robert J. Henning
Journal: JAMA (1990)

The careful and complete history and physical examination of the patient with a cardiac problem is not adequately stressed today in the training of physicians in the United States. Rather, medical students and physicians seek diagnostic answers for patients with cardiac problems from echocardiograms and Doppler ultrasonic studies, from radionucleotide examinations, from cardiac catheterization, and from computed tomographic and positron emission tomography studies. However, extremely important clues to the cardiac diagnosis, and often the diagnosis itself, can be obtained from a careful and complete history and physical examination of the patient. Recognizing this, Dr Jules Constant carefully documents the essential features of the complete history of a cardiac patient and discusses the salient points of all the major heart sounds and murmurs so that the careful reader and practitioner may become a more precise cardiac diagnostician. Dr Constant employes a Socratic approach of systematic questions followed by concise but fact-filled
The Impact of Cost Sharing on Emergency Department Use
Authors: Kevin F. O'Grady, Willard G. Manning, Joseph P. Newhouse, Robert H. Brook
Journal: New England Journal of Medicine (1985)

We studied the effect of insurance coverage on the use of emergency department services, using data from a national trial of cost sharing in health insurance. A total of 3973 persons below the age of 62 years were randomly assigned to fee-for-service health insurance plans with coinsurance rates of 0, 25, 50, or 95 per cent, subject to an income-related upper limit on out-of-pocket expenses. Persons with no cost sharing had emergency department expenses that were 42 per cent higher than those for persons on the 95 per cent plan (P less than 0.01) and about 16 per cent higher than those for persons with smaller amounts of cost sharing. Without cost sharing, emergency department visits for less serious diagnoses (e.g., abrasions) increased three times as much as did visits for more serious diagnoses (e.g., lacerations). After control for insurance, persons in the lower third of the income distribution had emergency department expenses that were 64 per cent higher than those in the upper third (P less than 0.001) and received a greater proportion of their ambulatory care in the emergency department. We conclude that the absence of cost sharing results in significantly greater emergency department use than does insurance with cost sharing. A disproportionate amount of the increased use involves less serious conditions.
Pediatric Cough and Fever: An Exercise in Clinical Problem Solving
Authors: Yan C. Chow
Journal: JAMA (1991)

Hands-on learning: that's an apt phrase for Pediatric Cough and Fever , a tutorial program from Mitchell J. Feldman, MD, and his colleagues at the Massachusetts General Hospital and Harvard Medical School. Pediatric Cough and Fever is part of the RxDx Training by Computer Series .  Cough with fever is an extremely common complaint in most general pediatric practices. The underlying causes can range from the benign to the life-threatening. Pediatric Cough and Fever offers a repertoire of 36 simulated pediatric cases, 18 of which are classic presentations, while another 18 represent more difficult and atypical challenges. Running the gamut from upper respiratory infection—viral to epiglottitis, the teaching caseload includes asthma, croup, sinusitis, chlamydial infection, pertussis, tuberculosis, mycoplasma, congestive heart failure, foreign body aspiration, and many others.  Intelligent alternatives in diagnostic workup and management exist for many diseases. The authors explain that Pediatric Cough and Fever 's value judgments represent the opinions
Hepatic transport of fluorescent molecules: In Vivo studies using intravital TV microscopy
Authors: I. A. Sherman, M. M. Fisher
Journal: Hepatology (1986)

Experiments were undertaken to evaluate the role of intravital epifluorescent TV microscopy in the study of the hepatic transport of sodium fluorescein and fluorescently labeled sodium glycocholate in rats and hamsters. It was found that the apparent sinusoid to canaliculus transport time for fluorescently labeled sodium glycocholate was only half of that for sodium fluorescein, 0.50 and 0.92 sec, respectively. The sinusoid to bile transport time was 35 sec for fluorescently labeled sodium glycocholate and 90 sec for sodium fluorescein. There were also marked differences in zonal clearance of these two substances. Sodium fluorescein was removed from Zone 1 much faster than from Zone 3, while fluorescently labeled sodium glycocholate was cleared at the same rate by hepatocytes in all three acinar zones. This study provides direct evidence that there are zonal differences in hepatic transport rates for certain compounds. It also demonstrates that epifluorescent TV microscopy has the potential to provide quantitative data on the transport rates of bile acids and other molecules into, through and out of the liver.
408 CD133+ STEM CELLS FOR THE TREATMENT OF END STAGE LIVER DISEASE
Authors: L. Brodosi, L. Catani, S. Lorenzini, R. Giordano, V. Giudice, D. Sollazzo, S. Gitto, M. Baccarani, M. Bernardi, R.M. Lemoli, P. Andreone
Journal: Journal of Hepatology (2012)
Editorial: Teratogenic effects of progestogen-estrogen
Authors: H. H. Hussey
Journal: JAMA (1974)

A few years ago, a flurry of reports noted the development of vaginal adenocarcinoma in adolescent girls and young women. In each case, the unusual cancer was linked circumstantially with administration of diethylstilbestrol to the patient's mother during a pregnancy considered to be at high risk because of bleeding or previous pregnancy loss. These facts duly received comment in an editorial inThe Journal,"Maternal Diethylstilbestrol a Time Bomb for Child?" by Kathryn S. Huss, MD (218:1564, 1971). In a forthcoming issue of<i>Archives of Environmental Health</i>, Nora and Nora<sup>1</sup>present evidence that suggests a teratogenic effect of other hormonal agents administered to pregnant women during the vulnerable period of embryogenesis (15 to 60 days' gestation). The patterns of anomalies in the offspring led the authors to adopt the acronym VACTERL (Vertebral, Anal, Cardiac, Tracheoesophageal, Renal, Limb). The implicated hormones were either a progestogen/estrogen compound or a progestogen alone
DRUGS AND ANIMAL EXPERIMENTATION
Authors: A. S. LOEVENHART
Journal: JAMA (1923)

The origin of the belief of mankind in the efficacy of drugs in the treatment of disease is a most interesting subject for speculation. The use of drugs antedates written accounts. Certainly the most primitive people on the earth today employ drugs as curative agents, and the earliest written records tell of the uses of drugs and poisons. We know that at certain periods disease was looked on as evidence of displeasure of the supreme being or beings, and that it was in the nature of a punishment visited upon man. The view has been expressed that, since many of the materials used as remedies are disagreeable, either in odor, taste, texture or their origin, the taking of the medicine was of the nature of a sacrifice to appease the gods. The fact that not all of the materials used by primitive people are abhorrent is opposed to this view.
Periostitis due to Low-Dose Fluoride Intoxication Demonstrated by Bone Scanning
Authors: TINA R. WEINGRAD, MICHAEL J. EYMONTT, JOHN H. MARTIN, MICHAEL D. STELTZ
Journal: Clinical Nuclear Medicine (1991)

In a patient with severe upper and lower extremity pain, bone scanning showed markedly increased activity along long bones. After low-dose sodium fluoride therapy for the treatment of osteoporosis was discontinued, the patient promptly became asymptomatic, and the bone scanning improved at 10 weeks.
Microchannel-based regenerative scaffold for chronic peripheral nerve interfacing in amputees
Authors: Akhil Srinivasan, Mayank Tahilramani, John T. Bentley, Russell K. Gore, Daniel C. Millard, Vivek J. Mukhatyar, Anish Joseph, Adel S. Haque, Garrett B. Stanley, Arthur W. English, Ravi V. Bellamkonda
Journal: Biomaterials (2014)
The Extremity and Circumferential Chest Lead Electrocardiogram in Induced Acute Coronary Insufficiency
Authors: KENNETH CHESKY, ARTHUR M. MASTER, HAROLD S. ARAI, LEON PORDY
Journal: Circulation (1951)

The extremity and circumferential chest lead electrocardiogram (twenty-two leads) was studied in 8 patients with generalized coronary insufficiency induced by exercise. Over the right chest, posteriorly and laterally, there was noted RS-T elevation similar to but less pronounced than that occurring in lead aV R . These leads probably represent true or mixed cavity potentials. Standard leads revealed more marked RS-T alterations after exercise than did aV leads. In the left anterior chest leads, the greatest RS-T depression occurred in the left unipolar precordial leads representing the maximal voltage of the R wave—usually V 4 or V 5 . The practical application of these findings is discussed in relation to routine two step exercise tests.
Empiric deworming to delay HIV disease progression in adults with HIV who are ineligible for initiation of antiretroviral treatment (the HEAT study): a multi-site, randomised trial
Authors: Judd Walson, Benson Singa, Laura Sangaré, Jaqueline Naulikha, Benjamin Piper, Barbra Richardson, Phelgona Apondi Otieno, Loice Wangari Mbogo, James A Berkley, Grace John-Stewart
Journal: The Lancet Infectious Diseases (2012)
Doctors' health matters
Authors: F. Godlee
Journal: BMJ (2008)

When Kjell Magne Bondevik became severely depressed he discussed the problem with his colleagues, told everyone the diagnosis, announced that he was taking time off for treatment, and after a month made a full return to work. This story might not seem remarkable except for the fact that he was then the prime minister of Norway. In this week’s BMJ , David Owen, a former doctor and leader of one of the UK’s political parties, says that Bondevik’s frankness earned him the respect of Norwegians and helped fight the stigma of mental illness (doi:10.1136/bmj.a2486). Owen calls for similar openness …
Tiotropium reduced exacerbations but not rate of FEV_1 decline in patients with COPD using other respiratory medications
Authors: Matthew B Stanbrook
Journal: Annals of Internal Medicine (2009)

ACP Journal Club20 January 2009Tiotropium reduced exacerbations but not rate of FEV1 decline in patients with COPD using other respiratory medicationsMatthew B. Stanbrook, MD, PhDMatthew B. Stanbrook, MD, PhDUniversity Health Network, University of Toronto, Toronto, Ontario, Canada (M.B.S.)Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-150-2-200901200-02007 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail Source CitationTashkin DP, Celli B, Senn S, et al. A 4-year trial of tiotropium in chronic obstructive pulmonary disease. N Engl J Med. 2008;359:1543-54. https://pubmed.ncbi.nlm.nih.gov/18836213Clinical Impact RatingsCardiology: Pulmonology: References1 Aaron SD, Vandemheen KL, Fergusson D, et al. Tiotropium in combination with placebo, salmeterol, or fluticasone-salmeterol for treatment of chronic obstructive pulmonary disease: a randomized trial. Ann Intern Med. 2007;146:545-55. [PMID: 17310045] Google Scholar2 Global Initiative for Chronic Obstructive Lung Disease. Global strategy for the diagnosis, management, and prevention of COPD. November 2008. www.goldcopd. org (accessed 9 Dec 2008). Google Scholar3 O’Donnell DE, Aaron S, Bourbeau J, et al. Canadian Thoracic Society recommendations for management of chronic obstructive pulmonary disease—2007 update. Can Respir J. 2007;14:5B-32B. [PMID: 17885691] Google Scholar Author, Article, and Disclosure InformationAffiliations: University Health Network, University of Toronto, Toronto, Ontario, Canada (M.B.S.)This article was published at Annals.org on 6 January 2009. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoReview: Inhaled anticholinergics increase risk for major cardiovascular events in chronic obstructive pulmonary disease Matthew B. Stanbrook Metrics 20 January 2009Volume 150, Issue 2Page: JC1-7KeywordsChronic obstructive pulmonary diseaseDrugsForced expiratory volume in the first second of expirationMortalityMyocardial infarctionQuality of lifeRelative riskSteroidsUpper respiratory tract infectionsVentilators ePublished: 20 January 2009 Issue Published: 20 January 2009 Copyright & PermissionsCopyright © 2009 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
AMPUTATION BELOW THE KNEE-JOINT IN PREFERENCE TO BRISMENT FORCE IN CERTAIN CASES OF DEFORMITY WITH ANCHYLOSIS. ILLUSTRATED BY TWO CASES.
Authors: LEWIS HALL SAYRE
Journal: JAMA (1883)

[Read in the Section on Surgery and Anatomy, June, 1883.] Gentlemen: In all chronic inflammations of the knee-joint, such as strumous synovitis, white swelling, fungus articuli, etc., there is a reflex muscular contraction, which, unless prevented or overcome by persistent extension and counter-extension during the progress of the disease, will result in more or less serious deformity, generally a partial or incomplete sub-luxation backward with outward rotation, in which position it may be anchylosed by fibrous adhesions, false anchylosis, or by bony fusion, true anchylosis. In all cases where the disease has entirely subsided, leaving this deformity, if it is possible to separate the patella from its adhesions with the femur, and if there is any movement whatever between the tibia and the femur, it is easier to resort to brisment forcé, even if it be necessary to make subcutaneous resection of the hamstring tendons in order that the leg
Placental transfer of an IgG paraprotein associated with prolonged immunosuppression.
Authors: J. M. Littlewood, I. Hunter, R. B. Payne, D. W. Miles
Journal: BMJ (1970)

range (mean ± 2 standard deviations) for age for each immunoglobulin is given in parentheses and is derived from the data of Allanamith, McClellan, Butter- worth, and Maloney (1968).