tbuckley/cabot-search huggingface dataset:
Staph Bacteria Plunder Heme for Iron
Authors: Tracy Hampton
Journal: JAMA (2004)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The Variation and Adaptive Expression of Antibodies.
Authors: George P. Smith
Journal: Annals of Internal Medicine (1974)

During the past ten years, several theories have been proposed on the origin of the diversity of antibodies. George P. Smith presents a critical study of these theories in this detailed treatment of immunological problems from the point of view of molecular genetics.   Mr. Smith uses a new and simplifying approach to this long-standing controversy. By a comprehensive computerized analysis of antibody amino acid sequences (particularly the myeloma proteins), the author traces their evolution and matches his results against the expectations of the various theories of diversity. He discusses at length the other types of evidence as well.   Mr. Smith also deals with the clonal specialization of cells to produce a single antibody, and the relationship of this specialization to the somatic joining of antibody half-genes, which is one of the immune system's most important peculiarities.   Introductory material is provided to make this work understandable to molecular geneticists not versed in immunology and to immunologists not versed in molecular genetics.   This is a timely book offering a succinct and coherent summary of the various lines of evidence in a confused and controversial field.
Abstract 4715: The Balance Between Polymer Degradation and Drug Concentration Determines the Neointimal Response to Stents Eluting Tacrolimus From a Biodegradable Polymer Coating up to 1 Year Post Stenting
Authors: Heleen M.M. van Beusekom, Oana Sorop, Jolanda Wentzel, Dirk J Duncker, Willem J van der Giessen
Journal: Circulation (2009)

Introduction: Efficacy of drug eluting stents (DES) to reduce neointimal thickness (NIT) varies between clinical reports. Important contributors to this response are the anti-proliferative, anti-in...
Psychiatric disorders and suicide attempts in Swedish survivors of the 2004 southeast Asia tsunami: a 5 year matched cohort study
Authors: Filip K Arnberg, Ragnhildur Gudmundsdóttir, Agnieszka Butwicka, Fang Fang, Paul Lichtenstein, Christina M Hultman, Unnur A Valdimarsdóttir
Journal: The Lancet Psychiatry (2015)
FAMILIAL LICHEN AMYLOIDOSIS.
Authors: K. RAJAGOPALAN, C. H. TAY
Journal: British Journal of Dermatology (1972)

Journal Article FAMILIAL LICHEN AMYLOIDOSIS: REPORT OF 19 CASES IN 4 GENERATIONS OF A CHINESE FAMILY IN MALAYSIA Get access K. RAJAGOPALAN, K. RAJAGOPALAN Skin Clinic, General Hospital, Johore Bahru, Malaysia, and Skin Clinic, Medical Unit III, Outram Road General Hospital, Singapore Search for other works by this author on: Oxford Academic Google Scholar C. H. TAY C. H. TAY Skin Clinic, General Hospital, Johore Bahru, Malaysia, and Skin Clinic, Medical Unit III, Outram Road General Hospital, Singapore Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 87, Issue 2, 1 August 1972, Pages 123–129, https://doi.org/10.1111/j.1365-2133.1972.tb16186.x Published: 01 August 1972 Article history Accepted: 09 March 1972 Published: 01 August 1972
Asthma, allergy and respiratory infections: the vitamin D hypothesis
Authors: S. Bozzetto, S. Carraro, G. Giordano, A. Boner, E. Baraldi
Journal: Allergy (2011)

To cite this article: Bozzetto S, Carraro S, Giordano G, Boner A, Baraldi E. Asthma, allergy, and respiratory infections: the vitamin D hypothesis. Allergy 2012; 67 : 10–17. Abstract The recent discovery that every tissue in the human body has vitamin D receptors and that vitamin D has pleiotropic effects has prompted an increased interest in this hormone. Vitamin D deficiency is widespread and on the increase. There is no consensus on the serum vitamin D levels to consider appropriate for global health, the cutoffs for its deficiency, or the doses to use for its supplementation. Vitamin D seems to correlate closely with host reactions against various respiratory infections. Epidemiological studies have shown that low serum 25‐hydroxyvitamin D levels are associated with a higher risk of upper and lower respiratory infections in children and a shortage of vitamin D may contribute to asthmatic patients’ symptoms and morbidity rates. There are studies highlighting associations between childhood asthma, fetal lung and/or immune development, and maternal vitamin D intake. An insufficiency of this vitamin also seems to be implicated in the onset of childhood atopy and food allergies. The hypothesis is that vitamin D could have a central role in these pathological situations and that it may represent a novel preventive and/or therapeutic strategy. This article reviews and discusses published data on the relationship between vitamin D and asthma and allergy, emphasizing the need for controlled, prospective studies on vitamin D supplementation to clarify whether it has a role in the prevention of and treatment for asthma and allergic conditions.
Redox-mediated Regulation of Histone deacetylase4, a Class II HDAC, by Thioredoxin1 through Interaction with DnaJb5, a Heat Shock Protein 40
Authors: Tetsuro Ago
Journal: Circulation (2007)

Abstract 283 Tetsuro Ago, Tong Liu, Hong Li, UMDNJ-NJMS, Newark, NJ; Jeffery Molkentin, Children’s Hosp Medical Center, Cincinnati, OH; Junichi Sadoshima, UMDNJ-NJMS, Newark, NJ Tetsuro Ago, 2007 F...
CXCR3 ligands promote expression of functional indoleamine 2,3-dioxygenase in basal cell carcinoma keratinocytes
Authors: B.K.K. Lo, R.B. Jalili, D. Zloty, A. Ghahary, B. Cowan, J.P. Dutz, N. Carr, J. Shapiro, K.J. McElwee
Journal: British Journal of Dermatology (2011)

Basal cell carcinoma (BCC) is the most common malignancy in humans worldwide. Studies suggest that BCCs exhibit immunoprotection, similar to other keratinocyte carcinomas, although the mechanisms of defence have not been defined.To examine if indoleamine 2,3-dioxygenase (IDO), an immune privilege-associated enzyme, would be expressed in BCC, regulated in part by CXCR3.We analysed the expression and function of IDO in human BCC (hBCC) tissues using nonlesional skin epithelial (NL) tissues as a control.Quantitative real-time reverse transcription-polymerase chain reaction (qPCR) revealed significant upregulation of IDO1 and IDO2 (12·5- and 19·14-fold change, respectively) in nodular hBCCs as compared with NL tissues. Immunohistochemistry showed that IDO colocalized with keratin 17, a BCC keratinocyte marker, in hBCC tissues. Western blot identified a full-length IDO (42 kDa) product and a splice variant (∼30 kDa) in BCC tissues. Kynurenine assays and qPCR were conducted to determine IDO enzymatic activity in hBCCs in vitro with CXCL11 supplementation, which has previously been shown to be required for the tumour cell growth. Addition of CXCL11 upregulated IDO2 and increased l-kynurenine concentration in a dose-dependent manner in hBCCs while normal primary keratinocytes exhibited no response.The expression of IDO at both mRNA and protein levels in hBCC tissues, the upregulation of IDO2 and the IDO-mediated l-kynurenine production in hBCCs with CXCL11 treatment suggest that functional IDO is synthesized by hBCC tumours and may be used as a method of immunoprotection during tumorigenesis. Also, IDO enzymatic activity may be modulated by CXCR3/CXCL11 signalling in BCCs.
THE EARLY FIELD DIAGNOSIS OF EPIDEMIC HEMORRHAGIC FEVER
Authors: William F. Ganong, Edward Zucker, Carroll K. Clawson, Edward C. Voss, Milton L. Klotzbach, Kenneth A. Platt
Journal: Annals of Internal Medicine (1953)

Article1 January 1953THE EARLY FIELD DIAGNOSIS OF EPIDEMIC HEMORRHAGIC FEVERWILLIAM F. GANONG, EDWARD ZUCKER, CARROLL K. CLAWSON, EDWARD C. VOSS, MILTON L. KLOTZBACH, KENNETH A. PLATTWILLIAM F. GANONGSearch for more papers by this author, EDWARD ZUCKERSearch for more papers by this author, CARROLL K. CLAWSONSearch for more papers by this author, EDWARD C. VOSSSearch for more papers by this author, MILTON L. KLOTZBACHSearch for more papers by this author, KENNETH A. PLATTSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-38-1-61 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptDuring the summer and autumn of 1951, the 1st Cavalry Division was deployed south and west of Yonchon, the center of the area from which the vast majority of cases of epidemic hemorrhagic fever originated. Between August 1 and December 10, 1951, a large number of cases clinically diagnosed as this disease were evacuated through the clearing station of the Division. Because the early features of this disease are difficult if not impossible to differentiate from other acute infections, it was felt that a report of experience gained from these cases would be of interest in emphasizing the points most... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: *Received for publication July 25, 1952.From the Clearing Company, 15th Medical Battalion, 1st Cavalry Division. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byPro: Heat stress as a potential etiology of Mesoamerican and Sri Lankan nephropathy: a late night consult with Sherlock HolmesPronounced Monocytosis in a Case of Nephropathia EpidemicaThe Brain and the Endocrine System: A MemoirHereditäre und endemische Nephropathien vorwiegend interstitieller LokalisationTHE FORTY-NINTH STARRENAL SEQUELÆ OF EPIDEMIC HÆMORRHAGIC FEVERDas epidemische h�morrhagische FieberDas haemorrhagische Fieber KoreasEPIDEMIC HÆMORRHAGIC FEVERThe sequelae of epidemic hemorrhagic feverAnalysis of sequential physiologic derangements in epidemic hemorrhagic feverII. The pathology of epidemic haemorrhagic fever 1 January 1953Volume 38, Issue 1Page: 61-66KeywordsHemorrhagic feversInfectious diseasesResearch laboratoriesTechnicians ePublished: 1 December 2008 Issue Published: 1 January 1953 PDF downloadLoading ...
Abstract 17216: Intracoronary Dual-modal OCT/NIRF Structural-Molecular Imaging with a Clinical Dose of Indocyanine Green (ICG) for Detection of High-risk Coronary Plaques in Diabetic Swine Model
Authors: Sunwon Kim, Min Woo Lee, Han Saem Cho, Joon Woo Song, Sunki Lee, Dong Joo Oh, Kyeongsoon Park, Wang-Yuhl Oh, Hongki Yoo, Jin Won Kim
Journal: Circulation (2014)

Background: Acute coronary syndrome is frequently caused by rupture of macrophage abundant plaques with a large lipid-rich core. The present study aimed to investigate whether a fully integrated OCT/NIRF imaging combined with a clinically available near-infrared fluorescence (NIRF) enhancing ICG can detect the inflamed, lipid-rich plaques in swine coronary atheromata whose phenotype is similar to human vulnerable fibroatheroma. Methods and Results: Accelerated atherosclerosis was made by coronary balloon denudation in alloxan induced diabetic minipigs. A rapid coronary imaging (20 mm/sec pullback speed) using a fully integrated OCT/NIRF catheter was safely performed 30 minutes after I.V. injection of ICG (2.0 mg/kg) just under contrast purge. OCT clearly identified the lipid-rich plaques with fibrous cap. Simultaneously acquired, distance-calibrated NIRF imaging detected lipid-laden macrophage signals in OCT-proven plaques (figure). The in vivo plaque target-to-background ratio (pTBR) was significantly higher in ICG-injected swine compared to non-diabetic swines or saline-injected controls (p&lt;0.05), which was validated on ex vivo fluorescence reflectance imaging (FRI) (figure). The in vivo and ex vivo peak pTBRs correlated significantly (p&lt;0.05). In vitro experiments, and histopathology including fluorescence microscopic imaging and immunostaining of the plaque sections corroborated the findings in vivo . Conlusions: An OCT/NIRF imaging with a clinical use of ICG accurately identified macrophage abundant, lipid-rich coronary plaques in diabetic atheromatous minipigs. This highly translatable dual-modal molecular-structural imaging could be relevant for clinical intracoronary detection of high-risk plaques.
Mapping of the estrogen receptor: GATA-3 interactome in MCF-7 human mammary carcinoma cells
Authors: Jane Thomsen, Say Li Kong, Vinsensius Vega, Yew Kok Lee, Sebastian Pott, Ruan Yijun, Edison Liu
Journal: Clinical Cancer Research (2007)

AACR Centennial Conference: Translational Cancer Medicine-- Nov 4-8, 2007; Singapore

C63 

Estrogens regulate the growth, differentiation and death of diverse target tissues, both within and outside of the reproductive system. Uncoupling of regulatory mechanisms can result in the initiation and progression of estrogen target tissue malignancies such as mammary, uterine and ovarian cancer. Most of the physiological actions of estrogens are mediated by the estrogen receptors (ER) α and β, which are ligand-activated transcription factors regulating a wide spectrum of estrogen-sensitive genes. ER signaling is carried out in conjunction with co-activators/repressors and other transcription factors. We have previously used a chromatin immunoprecipitation (ChIP)-paired end ditag (PET) cloning and sequencing strategy to comprehensively map the ERα binding sites in MCF-7 human mammary carcinoma cells following estrogen administration. We have now used a bioinformatics approach to identify which of the known transcription factor matrices are highly enriched in ER binding regions and found that one of them binds the zinc-finger transcription factor, GATA-3. GATA-3 expression is highly correlated with ERα status in breast tumors, and it has recently been reported that GATA-3 is essential for maintaining ERα expression in MCF-7 cells. By conducting ChIP-reChIP experiments, we have shown that GATA-3 and ERα binds to the same DNA fragments in MCF-7 cells, and by utilizing custom-made NimbleGen ChIP-on-chip arrays containing the universe of MCF-7 ER binding sites (>40,000 validated ChIP-PET, ChIP-chip and predicted EREs), we have identified GATA-3 and ERα cooccupancy at a large number of sites. We have also observed a good correlation between in silico predicted and in vivo validated GATA-3 binding sites. GATA-3 is co-localized with ER at both proximal and distal binding sites, and we are currently carrying out long-range interaction of GATA-3 binding sites in a genome-wide manner to map the 3-dimensional network of GATA-3.
Diabetes Mellitus, Obesity, and Diagnosis of Amyotrophic Lateral Sclerosis
Authors: Marianthi-Anna Kioumourtzoglou, Ran S. Rotem, Ryan M. Seals, Ole Gredal, Johnni Hansen, Marc G. Weisskopf
Journal: JAMA Neurology (2015)

Although prior studies have suggested a role of cardiometabolic health on pathogenesis of amyotrophic lateral sclerosis (ALS), the association with diabetes mellitus has not been widely examined. Amyotrophic lateral sclerosis is the most common motor neuron disorder. Several vascular risk factors have been associated with decreased risk for ALS. Although diabetes is also a risk factor for vascular disease, the few studies of diabetes and ALS have been inconsistent.To examine the association between diabetes and obesity, each identified through International Statistical Classification of Diseases, Eighth or Tenth Revision codes in a hospital registry, and ALS using data from the Danish National Registers.Population-based nested case-control study of 3650 Danish residents diagnosed as having ALS between January 1, 1982, and December 31, 2009, and 365,000 controls (100 for each ALS case) matched on age and sex. The analysis was conducted in September and October 2014.Adjusted odds ratio for ALS associated with diabetes or obesity diagnoses at least 3 years prior to the ALS diagnosis date.When considering diabetes and our obesity indicator together, the estimated odds ratio for ALS was 0.61 (95% CI, 0.46-0.80) for diabetes and 0.81 (95% CI, 0.57-1.16) for obesity. We observed no effect modification on the association with diabetes by sex. We did find a significant modification by age at ALS diagnosis and age at first mention of diabetes in the hospital registers. The protective association was stronger with increasing age at ALS diagnosis (P = .01), and the odds ratio for first mention of diabetes was 1.66 (95% CI, 0.85-3.21) before age 40 years but 0.52 (95% CI, 0.39-0.70) for older ages. These results are consistent with different associations for type 1 vs type 2 diabetes.In this Danish nationwide study to investigate the association between diabetes and ALS diagnosis, our findings are in agreement with previous reports of a protective association between vascular risk factors and ALS and suggest that type 2 diabetes, but not type 1, is protective for ALS.
Abstract 4379: Identification and characterization of therapeutic targets via microRNA profiling in HBV-related hepatocellular carcinoma
Authors: Keon U. Park, Jin Young Kim, Ilseon Hwang, Hun M. Ryoo, Sang-Woo Kim, Yun-Han Lee
Journal: Cancer Research (2014)

Abstract Hepatocellular carcinoma (HCC) is the most frequent type of liver cancer and it accounts for about 600,000 cancer deaths worldwide. Chronic infection with hepatitis B virus (HBV) is known to be responsible for most of HCC cases. HBV infections are especially common in Africa and some of Asian countries, including South Korea where 75% of HCC patients are infected with HBV. With traditional therapeutic strategies, such as surgical dissection or chemoembolization, 5-year survival rate of HCC patients is about 18%, demanding better understanding of molecular and cellular biology of the disease. MicroRNAs (miRNAs) are small noncoding single-stranded RNA molecules about 21-25 nucleotides long. miRNAs are involved in many cellular processes, including cell proliferation, apoptosis, and cell differentiation. Recently, it has been reported that deregulation of miRNAs contributes to the development of different types of human cancers but their role in HCC pathogenesis remains to be fully understood. In the present study, we performed a microarray-based genome-wide analysis of miRNA expression in 9 tissue samples from HCC patients and 7 noncancerous liver tissues to identify differentially expressed miRNAs. The expression of 183 and 84 miRNAs was found significantly up- and down-regulated in HCC samples compared with normal liver tissues, respectively (p &amp;lt; 0.05). Among prominent miRNAs are miR-17∼92 polycistronic oncomir, miR-200 family, miR-34, and miR-125b that are shown to be associated with HCC pathogenesis, demonstrating the validity of this miRNA profiling and warranting the identification and characterization of other miRNAs and their potential target genes. Taken together, our study demonstrates miRNA profiling in HCC that may be used as a diagnostic purposes. Citation Format: Keon Uk Park, Jin Young Kim, Ilseon Hwang, Hun Mo Ryoo, Sang-Woo Kim, Yun-Han Lee. Identification and characterization of therapeutic targets via microRNA profiling in HBV-related hepatocellular carcinoma. [abstract]. In: Proceedings of the 105th Annual Meeting of the American Association for Cancer Research; 2014 Apr 5-9; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2014;74(19 Suppl):Abstract nr 4379. doi:10.1158/1538-7445.AM2014-4379
Botulinum toxin in the treatment of sweat-worsened foot problems in patients with epidermolysis bullosa simplex and pachyonychia congenita
Authors: C. Swartling, M. Karlqvist, K. Hymnelius, J. Weis, A. Vahlquist
Journal: British Journal of Dermatology (2010)

Journal Article Botulinum toxin in the treatment of sweat‐worsened foot problems in patients with epidermolysis bullosa simplex and pachyonychia congenita Get access C. Swartling, C. Swartling Departments of DermatologySophiahemmet AB, Hidrosis Clinic, Box 5605, SE‐114 86 Stockholm, Sweden Correspondence: Carl Swartling. E‐mail: Carl.swartling@sophiahemmet.se Search for other works by this author on: Oxford Academic Google Scholar M. Karlqvist, M. Karlqvist Departments of DermatologyCentre for Research and Development, County Council of Gävleborg, Uppsala University, University Hospital, SE‐751 85 Uppsala, Sweden Search for other works by this author on: Oxford Academic Google Scholar K. Hymnelius, K. Hymnelius Departments of DermatologySophiahemmet AB, Hidrosis Clinic, Box 5605, SE‐114 86 Stockholm, Sweden Search for other works by this author on: Oxford Academic Google Scholar J. Weis, J. Weis Radiology, Search for other works by this author on: Oxford Academic Google Scholar A. Vahlquist A. Vahlquist Departments of Dermatology Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 163, Issue 5, 1 November 2010, Pages 1072–1076, https://doi.org/10.1111/j.1365-2133.2010.09927.x Published: 01 November 2010
Grand Rounds - Royal Liverpool University Hospital: Persistent post -traumatic stress disorder Often missed but worth treating
Authors: B C Bende, R M Philpott
Journal: BMJ (1994)

The incidence of pulmonary tuberculosis in children is estimated at 80 per 100 000; the incidence of AIDS has shown a sharp increase, especially among street children, who are prone to high risk behaviour.12A seroprevalence study carried out in 1992 in Grace Children's Hospital found that among those admitted for tuberculosis 14 5% tested seropositive for HIV.' AIDS is also spreading rapidly in the adult population, especially in rural areas, the result of internal migrations due to unemployment and political repression.Those displaced by internal migrations probably amount to more than 200 000.'In the slums of Cite Soleil, in Port au Prince, HIV seroprevalence was 10-3% in 1989, and in prostitutes the seroprevalence rose from 61% in 1987 to 72% in 1990.A high prevalence was also found in adolescents (15-19 years old) from urban areas.'Sixty per cent of children aged below 5 are estimated to be malnourished, and 3% of them have severe malnutrition.Before 1990 immunisation coverage with diphtheria, tetanus, and pertussis vaccine was 41%, with polio 40%, with BCG 72%, and with measles 32%.3After the political crisis in 1991 those already low coverage rates fell further, and only in 1992 and the beginning of 1993 were they increased as a result of collaboration with the private sector.'Although difficult to assess precisely, the incidence of mental illness is believed to have increased because ofthe climate of social and political instability, violence, and the rise in the use of drugs.'4In 1992 there were 360 registered admissions in the Beudet mental hospital, 135 more than in 1991.'Most people affected, however, do not even go to the hospitals because of the widespread belief in the supernatural nature of mental disease.