tbuckley/cabot-search huggingface dataset:
Fibreoptic bronchoscopy and the use of antibiotic prophylaxis.
Authors: J Haynes, M A Greenstone
Journal: BMJ (1987)

Pleural sarcoidosis is rare--it is little recognised in Birtian although several cases have been reported in the international literature. Three white men with pleural effusions caused by sacroidosis have been seen in a two-year period when approximately 60 new cases of thoracic sarcoidosis have been presented. In one patient a recurrent massive effusion was only diagnosed as being caused by sarcoidosis after thoractomy, and in two further patients small symptomatic pleural effusions were present at the onset of typical sarcoidosis. Two patients were successfully treated with steroids and the third improved spontaneously. Percutaneous biopsy is not always helpful in diagnosing pleural sarcoidosis, but a lymphocytic, often blood-stained, pleural aspirate is highly characteristic. While other diseases may coexist, a pleural effusion in a patient with histologically proven sarcoidosis is more likely to be caused by the primary disease than by any other condition.
THE MEMBRANE ATTACK MECHANISM OF COMPLEMENT
Authors: William P. Kolb, James A. Haxby, Carlos M. Arroyave, Hans J. Müller-Eberhard
Journal: The Journal of Experimental Medicine (1973)

Reversible interactions in free solution were demonstrated to occur (a) between C5 and C8, (b) between C5, 6, 7 and C8, and (c) between C8 and C9. No interaction was observed between C8 and C6 or C7 and between C9 and C5, 6, 7. Interactions between C8 and C9 were enhanced at lowered ionic strength (0.05) and a molar excess of C8 over C9. Complex formation was independent of pH over the range of 6.5-8.5. Under optimal conditions the C8, 9 complex had a sedimentation coefficient of 10.2-10.6S, while native C8 and C9 sedimented at 8.5 and 4.8S, respectively. Specificity and reversibility of these interactions were established. In spite of the limited number of interactions observed, all five of the native proteins of the membrane attack mechanism interacted to form an association product that sedimented at 10.8-11.2S. Demonstration of this product in free solution supports the concept that C5-9 on acquisition of cytolytic activity assemble into a stable multimolecular complex.
The familial Mediterranean fever protein, pyrin, is cleaved by caspase-1 and activates NF-κB through its N-terminal fragment
Authors: Jae Jin Chae, Geryl Wood, Katharina Richard, Howard Jaffe, Nona T. Colburn, Seth L. Masters, Deborah L. Gumucio, Nitza G. Shoham, Daniel L. Kastner
Journal: Blood (2008)
Hemoglobin pasadena: Identification of the gene mutant by DNA analysis using synthetic DNA probes
Authors: Samuel Rahbar, Robert Rosen, Guity Nozari, Terry D. Lee, Yayesh Asmerom, R. Bruce Wallace
Journal: American Journal of Hematology (1988)

Abstract Hemoglobin Pasadena [β75(E19)Leu→Arg] was found in a boy who had an acute episode of anemia and rapid splenic enlargement. His father was the only other member of a large family with this hemoglobinopathy. We have used gene mapping techniques for direct identification of the β‐globin gene mutation. To correlate the DNA findings with the structural identification of this variant, we have also performed globin chain separation and analysis of the tryptic peptides using high performance liquid chromatography and secondary ion mass spectral analysis.
BMJ pico--a window into the future?
Authors: T. Jefferson, L. D. Fiore
Journal: BMJ (2009)

We have been invited to join the BMJ pico pilot study1 but can’t decide.

Some of us are dubious about doing more work on a paper which has already been rewritten four times; others fear that publishing just an abstract in the print journal will diminish our work’s visibility.1

We wondered about the motives behind further reducing the paper research content while retaining the full electronic version of papers. Our first reaction was surprise as one …
Do Cultural Differences Affect Alzheimer Disease?
Authors: George M. Martin
Journal: JAMA (1996)

To varying degrees, all diseases are the result of naturenurture interactions. Evolutionary biological theory indicates that diseases that unfold during the late stages of life are attributable to those interactions that have escaped the force of natural selection and thus, in the absence of some intelligent biomedical or environmental interventions, may be inevitable components of senescence. These patterns can be expected to vary among species and among members of a given species. For those members of our species living in the Western world, dementias of the Alzheimer type (DATs) appear to be extraordinarily prevalent. Incidence doubles about every 5 years beginning at age 65 years.<sup>1</sup>Prevalence rates as high as 37.0% to 63.2% (95% confidence limits) have been reported for those over age 85 years.<sup>2</sup> See also p 955. In the course of less than a decade, there have been major advances on the genetic side of the
Thromboprophylaxis with rivaroxaban or enoxaparin did not differ for major bleeding in knee arthroplasty
Authors: Pieter W. Kamphuisen
Journal: Annals of Internal Medicine (2008)

ACP Journal Club21 October 2008Thromboprophylaxis with rivaroxaban or enoxaparin did not differ for major bleeding in knee arthroplastyPieter W. Kamphuisen, MDPieter W. Kamphuisen, MDAcademic Medical Center, Amsterdam, The Netherlands (P.W.K.)Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-149-8-200810210-02007 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail Source CitationLassen MR, Ageno W, Borris LC, et al. Rivaroxaban versus enoxaparin for thromboprophylaxis after total knee arthroplasty. N Engl J Med. 2008;358:2776-86. https://pubmed.ncbi.nlm.nih.gov/18579812Clinical Impact RatingsHematology: Author, Article, and Disclosure InformationAffiliations: Academic Medical Center, Amsterdam, The Netherlands (P.W.K.)This article was published at Annals.org on 7 October 2008. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoThromboprophylaxis with rivaroxaban or enoxaparin did not differ for major bleeding or other safety outcomes in hip arthroplasty Pieter W. Kamphuisen Metrics 21 October 2008Volume 149, Issue 8Page: JC4-7KeywordsAnticoagulantsArthroplastyDrugsHemorrhageHipKneesOrthopedic surgerySafetySurgeryTotal knee arthroplasty ePublished: 21 October 2008 Issue Published: 21 October 2008 Copyright & PermissionsCopyright © 2008 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Corrections: Crimson Crescents—A Possible Association with the Chronic Fatigue Syndrome
Authors: B.A. Cunha
Journal: Annals of Internal Medicine (1992)

Letters1 May 1992Corrections: Crimson Crescents—A Possible Association with the Chronic Fatigue SyndromeB.A. Cunha, MDB.A. Cunha, MDSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-116-9-779_3 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptA sentence in a letter (1) should have read as follows. This appearance is most closely associated with elevatedHHV-6 titersin our patients....Reference1. Cunha B. Crimson crescents—a possible association with the chronic fatigue syndrome. Ann Intern Med. 1992;116:347. LinkGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Winthrop-University Hospital Mineola, NY 11501 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 May 1992Volume 116, Issue 9Page: 779-779KeywordsChronic fatigue syndrome Issue Published: 1 May 1992 PDF DownloadLoading ...
IMPLANTATION, TRANSPLANTATION, AND EPITHELIAL-MESENCHYMAL RELATIONSHIPS IN THE RAT UTERUS
Authors: Alan E. Beer, R. E. Billingham
Journal: The Journal of Experimental Medicine (1970)

Free tail skin grafts or suspensions of viable epidermal cells have been placed in the atraumatized uterus of isologous rat hosts and allowed to "implant" of their own accord to study the possible uniqueness of this site for other than nature's transplants, i.e. conceptuses, and its response to unnatural grafts. Despite the presence of an intact endometrial epithelium, free skin grafts heal-in rapidly, provided that a state of estrogen excess is established at the time of transplantation. In the absence of estrogen most of the grafts failed to implant. Once established, the grafts survive indefinitely without further estrogen. However, if at any stage a state of continual estrus is established, skin epidermis migrates centrifugally from the graft perimeter invasively replacing the native uterine epithelium. The results of an analysis of the modus operandi of this estrogen-facilitated epidermal migration in utero sustain the view that the hormone acts upon the uterine stroma rather than upon the epidermal cells. When grafts of lingual mucosa or vaginal "skin" were placed in the uteri of rats maintained in chronic estrus, migration of epidermis took place even more vigorously than from tail skin. These epithelia conserved their distinctive histologic specificities indefinitely when growing as heterotypic recombinants on the alien mesenchymal stroma of the uterus. Monodisperse suspensions of epidermal cells appear to "implant" and establish small epidermal plaques in the uterus only at sites predestined to accept conceptuses. That the endocrinologic parameters for the establishment of skin grafts in the uterus are similar to those for blastocysts is suggested by the finding that both kinds of graft can become established in the same uterine horn in the absence of exogenous hormones.
Extraction of self-expanding metallic common bile duct stents with snare and Soehendra lithotripter
Authors: P. Heinerman, J. Holzinger
Journal: Endoscopy (2010)

Self-expanding metallic stents (SEMS) are commonly used for palliation in patients with obstruction of the bile duct. Extraction of SEMS when they become occluded is difficult, sometimes even impossible [1] [2] [3] [4]. We describe a new extraction method used in two patients.
Body fat mass and lean mass as predictors of survival in hemodialysis patients
Authors: R. Kakiya, T. Shoji, Y. Tsujimoto, N. Tatsumi, S. Hatsuda, K. Shinohara, E. Kimoto, H. Tahara, H. Koyama, M. Emoto, E. Ishimura, T. Miki, T. Tabata, Y. Nishizawa
Journal: Kidney International (2006)
Senior Canadian physician and hospital administrator wanted for fraud involving hospital contract arrested in Panama
Authors: B. Kermode-Scott
Journal: BMJ (2013)

The former highly respected physician, academic, and hospital administrator Arthur T Porter—wanted by the Canadian authorities for fraud over the handling of a $C1.3bn (£0.83bn; €0.97bn; $1.26bn) hospital contract—has been arrested in Panama by Interpol.

Canadian authorities are seeking the extradition of Arthur Porter, who was arrested on 27 May 2013, and his wife Pamela Mattock Porter, who was arrested one day earlier, accused of laundering the proceeds of crime and conspiracy.

Quebec prosecutors charged Arthur Porter with fraud in February 2013, as well as conspiracy to commit fraud, fraud against the government, breach of trust, taking secret commissions, and …
p63 and IRF6: brothers in arms against cleft palate
Authors: Amel Gritli-Linde
Journal: Journal of Clinical Investigation (2010)

Cleft lip and cleft palate, which can also occur together as cleft lip and palate, are frequent and debilitating congenital malformations, with complex geneses that have both genetic and environmental factors implicated. Mutations in the genes encoding the p53 homolog p63 and interferon regulatory factor 6 (IRF6) are major causes of cleft lip and cleft palate, but the molecular and cellular mechanisms underlying this have not been clear. However, in this issue of the JCI, Thomason et al. and Moretti et al. independently show that p63 and IRF6 operate within a regulatory loop to coordinate epithelial proliferation and differentiation during normal palate development. Disruption of this loop as a result of mutations in p63 or IRF6 causes congenital clefting.
Prescribing in pregnancy. Identifying abnormalities.
Authors: M J Whittle, K P Hanretty
Journal: BMJ (1986)

Drugs taken during pregnancy create concern whether they are self administered or medically prescribed.The number of mothers who take drugs during pregnancy is not known, but a survey in the United States showed that about 45% of women may use at least one drug on prescription, and many more use drugs bought over the counter.'A recent prospective study in the United Kingdom, however, suggested that only about 10% of women took drugs in early pregnancy.2Defects occur in about 2% to 3% ofbabies at birth, ofwhich about 25% are of genetic origin and 65% are of unknown aetiology.Only 2% to 3% of defects are thought to arise in association with drug treatment.3The effect of a particular drug on the developing fetus depends on several features, including the type of agent and the gestational age at which it was taken.The aim of this article is to provide a guide for doctors treating pregnant women who have taken, or who are currently taking, drugs.Advice depends on the following: (a) knowledge of the timing of embryonic and fetal development because preparations taken outside the critical phases are unlikely to be teratogenic; (b) the precise nature of the drug so that the teratogenic effect may be determined (table ); and (c) whether the teratogenic effect is likely to be sufficiently apparent to make prenatal diagnosis feasible.During the pre-embryonic phase, from conception until 17 days, implantation, blastocyst formation, and gastrulation take place.
The Purpose and Limits to Professional Self-regulation
Authors: Cyril Chantler, Rebecca Ashton
Journal: JAMA (2009)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Expansion of the neonatal platelet mass is achieved via an extension of platelet lifespan
Authors: Zhi-Jian Liu, Karin M. Hoffmeister, Zhongbo Hu, Donald E. Mager, Sihem Ait-Oudhia, Marlyse A. Debrincat, Irina Pleines, Emma C. Josefsson, Benjamin T. Kile, Joseph Italiano, Haley Ramsey, Renata Grozovsky, Peter Veng-Pedersen, Chaitanya Chavda, Martha Sola-Visner
Journal: Blood (2014)
Reversible Electrocardiographic Changes Associated With Wasp Sting Anaphylaxis
Authors: George W. Brasher
Journal: JAMA (1974)

DEATH from anaphylaxis in humans often results from laryngeal edema or acute pulmonary emphysema. In the following case, nearly fatal anaphylaxis after a wasp sting produced dramatic and reversible electrocardiographic changes. <h3>Report of a Case</h3> Twenty minutes after a wasp sting, a 62-year-old man with angina pectoris complained of shortness of breath, became confused, fell backwards, and turned a bluish color. He was rushed to the emergency room of Scott and White Memorial Hospital. Arriving at 10:52 AM, the patient was described by the admitting physician as "markedly dyspneic, sweaty and cyanotic, with bubbly white sputum running out of the mouth." The physician recorded a blood pressure of 120/90 mm Hg, and noted that "the lungs were tight with moist rales," and "heart tones were inaudible." Within five minutes, intermittent positive pressure breathing with oxygen was administered, as were hydrocortisone sodium succinate (Solu-Cortef), 100 mg, and furosemide (Lasix), 40 mg,
The Effect of Aging on Lung Perfusion
Authors: RICHARD S. KRONENBERG
Journal: Annals of Internal Medicine (1972)

The effect of age on the uniformity of lung perfusion was studied, using intravenous injections of 99mTc-labeled albumin microspheres, in a group of 30 normal men with a mean age of 69.6 years. Uniformity was assessed by computer-generated contour plots, photoscintigrams, and chest X rays. The results were compared with similar data obtained from young normal subjects and patients with chronic obstructive lung disease. Both the contour plots and photoscintigrams provided statistically significant differentiation among the three groups of subjects, but the contour plots were more discriminating. None of the normal subjects were judged abnormal by the contour plot technique. Lung perfusion in the old normal subjects was uniform and closely resembled that seen in the young normal subjects. The finding of perfusion defects in photoscintigrams of patients over 50 years of age cannot be presumed to be a consequence of age but probably represents significant pulmonary abnormality.
Preexposure Prophylaxis for HIV
Authors: Albert Y. Liu, Robert M. Grant, Susan P. Buchbinder
Journal: JAMA (2006)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Primary Medical Care
Authors: Geoffrey N. Marsh
Journal: JAMA (1976)

THE BRITISH National Health Service, now over a quarter of a century old, was introduced against a hail of criticism by doctors on both sides of the Atlantic. The criticism from the American Medical Association has continued across the years, although distinguished American dissentients from this view are now being heard.<sup>1-3</sup>Promulgated by all three major political parties in Great Britain and effectively introduced by the Labor Party in 1948, the Service was part of a welfare package offered to a nation whose earlier wartime struggles appeared to have produced little in immediate material benefit. In 1948, the backlash of a war lay heavily on the community and manifested itself in anxieties, depressions, psychosomatic illnesses, and marital breakdowns. Many people had conditions for which therapy had not been sought because of the medical stringencies of the war years; others had handicaps as a result of war injuries. In addition,
Simplified criteria for the diagnosis of autoimmune hepatitis
Authors: Elke M. Hennes, Mikio Zeniya, Albert. J. Czaja, Albert Parés, George N. Dalekos, Edward L. Krawitt, Paulo L. Bittencourt, Gilda Porta, Kirsten M. Boberg, Harald Hofer, Francesco B. Bianchi, Minoru Shibata, Christoph Schramm, Barbara Eisenmann de Torres, Peter R. Galle, Ian McFarlane, Hans‐Peter Dienes, Ansgar W. Lohse
Journal: Hepatology (2008)

Diagnosis of autoimmune hepatitis (AIH) may be challenging. However, early diagnosis is important because immunosuppression is life-saving. Diagnostic criteria of the International Autoimmune Hepatitis Group (IAIHG) were complex and purely meant for scientific purposes. This study of the IAIHG aims to define simplified diagnostic criteria for routine clinical practice. Candidate criteria included sex, age, autoantibodies, immunoglobulins, absence of viral hepatitis, and histology. The training set included 250 AIH patients and 193 controls from 11 centers worldwide. Scores were built from variables showing predictive ability in univariate analysis. Diagnostic value of each score was assessed by the area under the receiver operating characteristic (ROC) curve. The best score was validated using data of an additional 109 AIH patients and 284 controls. This score included autoantibodies, immunoglobulin G, histology, and exclusion of viral hepatitis. The area under the curve for prediction of AIH was 0.946 in the training set and 0.91 in the validation set. Based on the ROC curves, two cutoff points were chosen. The score was found to have 88% sensitivity and 97% specificity (cutoff ≥6) and 81% sensitivity and 99% specificity (cutoff ≥7) in the validation set. Conclusion: A reliable diagnosis of AIH can be made using a very simple diagnostic score. We propose the diagnosis of probable AIH at a cutoff point greater than 6 points and definite AIH 7 points or higher. (HEPATOLOGY 2008.)
Pig virus transfer threatens xenotransplantation
Authors: J. Wise
Journal: BMJ (1997)

Pig retroviruses can infect human cells in laboratory conditions and replicate themselves, researchers have discovered. The finding will affect the future of xenotransplantation–the transfer of animal tissue into humans.

Earlier this year the British authorities decided that more research was needed before trials to transplant pig organs into humans could go ahead (25 January, p 247). One of the main concerns expressed in the advisory committee's report, Animal Tissue into Humans , was the possibility that animal viruses may be transferred to humans. However, in the United States pressure from the transplant community has …
Nicaragua: The Role of USAID-Reply
Authors: Richard Garfield
Journal: JAMA (1994)

<h3>In Reply.</h3> —Our article stated that USAID and PAHO were the main organizations to respond quickly to the new situation in 1990. We also mentioned USAID's valuable support for family planning, provision of essential medicines, and responses to regional emergencies. The letter from Dr Ballantyne details these and other important activities. In our conclusions, we discuss the importance of cooperation among international organizations and agencies to support primary care development. The USAID is working closely with the Ministry of Health to promote decentralization of health services and primary care through the strengthening of local health systems throughout the country. This experience and these models will likely be of keen interest to other developing countries in the coming years.