tbuckley/cabot-search huggingface dataset:
Abstract 20162: Comparision of Procedural and 30 Day Outcomes of Roataional vs Orbital Atherectomy in Severely Calcified Coronary Lesions
Authors: Anitha Rajamanickam, Usman Baber, Melissa Aquino, Swathi Roy, Annapoorna Kini, Samin Sharma
Journal: Circulation (2014)

Introduction: The percutaneous treatment of heavily calcified coronary lesions remains suboptimal and often requires debulking with Rotational Atherectomy (RA) which is often underutilized due to a steep learning curve. Although a novel approach using Orbital Atherectomy (OA) has been introduced, which has an easier set-up and easier learning curve, a comparative assessment of both techniques in real world cohort has not been performed METHODS: Retrospective analysis of our prospectively collected database between October 2013 to May 2014 for patients undergoing atherectomy in heavily calcified lesions at our center retrieved 105 OA and 196 RA procedures RESULTS: There were no significant differences in patient demographics.The maximal stent diameter was significantly larger in OA vs RA (3.41 mm 2 vs 3.28 mm 2 , p=0.02).There was a trend towards RA showing better Procedural success defined as successful stent deployment with TIMI 3 flow ( 95.9% vs 90.5%, p = 0.06) and Clinical Success which is procedural success without death, stroke or CABG ( 95.9% vs 90.5%, p = 0.06). Two cases of failed initial OA underwent successful RA. Procedural complications (≥ grade 3 dissection, side branch closure, perforation, slow flow/no flow or vessel closure), In-hospital MACE (a composite of death, stroke, CABG or CKMB&gt;5X), 30 day readmission rates and 30 day MACE were not statistically significant[See Table 1 and Figure 1]. CONCLUSION: OA demonstrated a similar safety and efficacy profile to RA with a trend towards lower procedural success but comparable complications and 30 day outcomes, suggesting OA may serve as an alternative to RA in PCI of heavily calcified lesions.
Outcome and Profile of Women and Men Presenting With Acute Coronary Syndromes: A Report From TIMI IIIB
Authors: Judith S. Hochman, Carolyn H. McCabe, Peter H. Stone, Richard C. Becker, Christopher P. Cannon, Tia DeFeo-Fraulini, Bruce Thompson, Richard Steingart, Genell Knatterud, Eugene Braunwald
Journal: Journal of the American College of Cardiology (1997)

Objectives. Women and men enrolled in the Thrombolysis in Myocardial Infarction (TIMI) IIIB trial of unstable angina and non–Q wave myocardial infarction (MI) were evaluated to determine gender differences in characteristics and outcome. Background. Coronary heart disease is the leading cause of death for women and men. However, the characteristics and outcome of women compared with men with unstable angina and non–Q wave MI have not been extensively studied. Methods. The characteristics, outcomes and proportion of 497 women and 976 men with unstable angina and non–Q wave MI at the time of enrollment were compared. When these proportions were noted to be significantly different, we compared them with the 7,731-patient TIMI IIIB Registry, which represents the nontrial, screened population with these syndromes at these centers. Results. For both coronary syndromes, women were older, were less frequently white, had a higher incidence of diabetes and hypertension and were receiving more cardiac medications. The 42-day rate of death and MI in TIMI IIIB was similar for women and men (7.4% vs. 7.5%). Coronary angiography revealed less severe coronary artery disease for women than for men, with absence of critical obstructions in 25% versus 16% and mean ejection fractions 62 ± 12% versus 57 ± 13% for women versus men (p < 0.01). Medical management failed in women as often as in men, and rates of cardiac catheterization and percutaneous transluminal coronary angioplasty or coronary artery bypass graft surgery were similar for women and men in the conservative strategy arm as well as in the invasive strategy arm. Women in the TIMI IIIB trial had proportionately more unstable angina than did men. The proportion of unstable angina and non–Q wave MI for women was similar in the trial and Registry. However, proportionately more men in the trial had non–Q wave MI than men in the Registry. Conclusions. 1) Women with each acute coronary syndrome are older than men and have more comorbidity. 2) The outcome with unstable angina and non–Q wave MI is related to severity of illness and not gender. 3) Mortality associated with revascularization for unstable angina and non–Q wave MI was similar for women and men. 4) The proportion of women and men enrolled with each acute coronary syndrome is different. These rates reflect both the prevalence of disease and selection bias owing to trial eligibility criteria and other identified factors. (J Am Coll Cardiol 1997;30:141–8)
Abstract 17982: A lamin A/C Synonymous Mutation Creates a Novel Splice Site and Causes Progressive Atrioventricular Conduction Defect
Authors: Kaoru Ito, Barbara McDonough, Joshua M Gorham, Steven R DeParma, Emily E Adler, Syed M Mohiuddin, Diane Fatkin, J G Seidman, Christine E Seidman
Journal: Circulation (2014)

Background:  Mutations in the lamin A/C, encoded by LMNA, produce diverse genetic disorders, collectively termed laminopathies including disease of cardiac and skeletal muscles, peripheral neuropathy, lipodystrophy and premature aging syndromes. Cardiac phenotypes associated with LMNA mutations include progressive cardiac conduction defects and dilated cardiomyopathy (DCM), and this has been attributed predominantly to missense variants and less commonly to truncating variants. Synonymous sequence variants are usually considered benign and have not been investigated in cardiac laminopathies. Here we report the identification of A LMNA synonymous mutation that mimics a splice donor consensus sequence and causes a 15 amino acid deletion in the exon 4.   Methods and Results:  We conducted a linkage analysis by genome-wide SNP genotyping method and found one region with LOD score > 4 on chr1q21.3-q23.3, which includes LMNA. Exome sequencing was performed in 4 affected subjects. 3 unique variants that were shared by the affected Subjects were identified in the linkage region. One variant, a synonymous change in the LMNA gene, was selected for further analysis, since LMNA is a strong candidate gene for the family’s phenotype and the variant was predicted to introduce a new potential splice donor site. Sanger sequencing samples from the extended pedigree confirmed that the synonymous LMNA variant was present in all affected subjects and absent from unaffected subjects. Evaluation of myocardial tissue from one affected family member using RT-PCR showed the expected band of 240 bp size and an additional smaller band of 195 bp size, suggestive a potential effect of the variant on RNA splicing. Sanger sequencing of the smaller band revealed a 45-bp in-frame deletion in the tail of the exon4, indicating that this variant activates a cryptic splice donor site.   Conclusion:  Here we report a novel synonymous LMNA variant, c.768G>A, in a family with DCM and conduction-system disease, this variant appears to alter RNA splicing by activating a cryptic splice donor site. These findings expand the spectrum of LMNA mutations associated with cardiac laminopathies and highlight the potential pathogenicity of synonymous sequence variants.
Nicholas Culpeper, Father of English Midwifery
Authors: Olav Thulesius
Journal: Journal of the Royal Society of Medicine (1994)

In Britain, Nicholas Culpeper (1616-1654) is the household name for herbal medicine. He is famous for his herbal, The English Physitian, which first appeared in 1652 and since then has been reprinted in over 100 editions, not only in England but also in America where it became the first medical book to be published (Boston 1708). Culpeper also was renowned for his translations ofa number ofimportant medical texts such as the London Dispensatory into English (1651), Bartholinus Anatomy and many others. He has undeservedly earned the reputation of a quacksalver since he was in conflict with the College of Physicians and believed in astrology, something he, however, shared with many of his contemporaries. In the seventeenth century astrology was still so deeply rooted in everybody's mind that we can find traces of it in the writings of William Harvey and Francis Bacon'.
Platelet activation and arterial peripheral serotonin turnover in cardiac remodeling associated to aortic stenosis
Authors: Charlotte Rouzaud‐Laborde, Clément Delmas, Nathalie Pizzinat, Florence Tortosa, Cédric Garcia, Jeanne Mialet‐Perez, Bernard Payrastre, Pierre Sié, Odile Spreux‐Varoquaux, Brigitte Sallerin, Didier Carrié, Michel Galinier, Angelo Parini, Olivier Lairez
Journal: American Journal of Hematology (2014)

Peripheral serotonin (5-HT) has been involved in adverse cardiac remodeling and valve fibrosis. The peripheral levels of 5-HT mainly depend on its release from activated platelets and degradation by monoamine oxidase A (MAO-A). The SERAOPI study investigated the relationship between arterial serotoninergic system, degree of platelet activation and cardiac remodeling, in patients with aortic valve stenosis (AS). Thirty patients with severe AS and 15 control subjects underwent transthoracic echocardiography, radial, and aortic arterial blood sampling. Measurements of 5-HT and its MAO-A-dependent degradation product, 5-HIAA, were performed by HPLC. Arterial platelet activation was assessed by flow cytometry analysis of platelet surface expression of P-selectin and activated integrin GPIIb/IIIa. Activated platelets and arterial plasma 5-HT increased in AS patients as compared to control subjects (P-selectin 1.08 ± 0.2MFI vs. 0.49 ± 0.1MFI, P = 0.04; GPIIb/IIIa 0.71 ± 0.1MFI vs. 0.35 ± 0.1MFI; P = 0.0015 and arterial plasma 5-HT 11.55 ± 1.6 nM vs. 6.18 ± 0.7 nM, P = 0.028, respectively). Moreover, 5-HT was strongly correlated to left ventricular hypertrophy assessed by echocardiography. The correlation was independent of cardiovascular risk comorbidities and others echocardiographic AS parameters. Finally, plasma 5-HIAA increased in AS patients (74.64 ± 9.7 nM vs. 37.16 ± 4.1 nM; P = 0.0002) indicating a higher 5-HT degradation rate by MAO-A. Platelet activation, arterial circulating serotonin, and serotonin degradation increased in patients with AS. These observations suggest that the serotoninergic system may contribute to the pathogenesis of AS including valve fibrosis and adverse ventricular remodeling.
A memorable patient: An oldfashioned miracle
Authors: T Kirkpatrick
Journal: BMJ (1998)

A patient developed chest pains at home on Easter Friday; his wife suspected that he was having a heart attack and drove him to the nearest accident and emergency department in their own car. During the short journey, the patient lost consciousness and became cyanosed. On arrival at the hospital he was found to be in cardiac arrest. He was successfully resuscitated and then transferred to the intensive care ward where he was sedated …
Synthetic Tooth Enamel
Authors: Joan Stephenson
Journal: JAMA (2005)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Metformin and B_12 Malabsorption
Authors: GERALD H. TOMKIN
Journal: Annals of Internal Medicine (1972)

Letters, Comments, and Corrections1 April 1972Metformin and B12 MalabsorptionGERALD H. TOMKIN, M.D.GERALD H. TOMKIN, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-76-4-668_1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: I read Dr. Herbert's editorial with interest [Ann Intern Med76:140-141, 1972] and agree that the intestinal malabsorption caused by the biguanides may be dose-dependent, although we were unable to show this in our series of patients receiving metformin (1) (perhaps because there was too small a variation in dose used). Experimentally, with the everted intestinal sac technique, the uptake of [57Co]B12by guinea pig intestine incubated in Kreb's buffer for 1 hour was significantly inhibited when either metformin, phenformin, or buformin was added to the incubation media in concentrations greater than 1.0 mg/ml, but there was...References1. TOMKINHADDENWEAVER GDJ: Vitamin B12 status of patients on long-term metformin therapy. Br Med J 2:685-687, 1971 CrossrefMedlineGoogle Scholar2. TOMKINLOVE GA: Investigation of glucose transport and 57Co vitamin B12 uptake using the everted sac technique with histological examination of the sacs after suspension in bile salts and indole. Digestion. In press Google Scholar3. STOWERSSMITH JO: Vitamin B12 and metformin. Br Med J 3:246-247, 1971 CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byCognitive impairment and vitamin B12: a review 1 April 1972Volume 76, Issue 4Page: 668-668KeywordsAttentionGuinea pigs Issue Published: 1 April 1972 PDF downloadLoading ...
Website of the week: Women in surgery
Authors: D. Carnall
Journal: BMJ (1999)

It is an embarrassment that the percentage of women consultant surgeons remains in single figures despite almost two decades of sex balanced intake to medical school, and last week the Royal College of Surgeons announced its plans to do something about it (see news p 802). Presumably influenced by its Women in Surgical Training Committee (www.rcseng.ac.uk/public/collmed/boards.htm#wist), it plans …
An α-2-macroglobulin insertion-deletion polymorphism in Alzheimer disease (reply)
Authors: Ekaterina A. Rogaeva, Smita Premkumar, Janet Grubber, Lutgarde Serneels, William K. Scott, Toshitaka Kawarai, Youqiang Song, De’Lisa M. Hill, Suzanne M. Abou-Donia, Eden R. Martin, Jeffrey J. Vance, Gang Yu, Antonio Orlacchio, York Pei, Masaki Nishimura, Agres Supala, Brenda Roberge, Ann M. Saunders, Allen D. Roses, Donald Schmechel, Alison Crane-Gatherum, Sandro Sorbi, Amalia Bruni, Gary W. Small, P. Michael Conneally, Jonathan L. Haines, Fred Van Leuven, Peter H St George-Hyslop, Lindsay A. Farrer, Margaret A. Pericak-Vance
Journal: Nature Genetics (1999)
Abstract 18486: Serial Measurements of High-Sensitive Cardiac N-terminal Pro B-type Natriuretic Peptide Predict Prognosis of Ambulant Chronic Heart Failure Patients: Results of the Bio-shift Study
Authors: Nick van Boven, Linda C Battes, K M Akkerhuis, Kadir Caliskan, Jannette Langstraat, Dimitris Rizopoulos, Eric Boersma, Victor A Umans, Isabella Kardys
Journal: Circulation (2014)

Introduction: N-terminal pro B-type natriuretic peptide (NT-proBNP) has prognostic value in chronic heart failure (CHF) patients, but most studies evaluated single or few measurements only. Hypothesis: We think that longer term NT-proBNP patterns in CHF patients facilitate assessing prognosis. Methods: From 2011 to 2013, 263 ambulant CHF patients were included in 2 hospitals. NT-proBNP was measured at baseline and every 3 months. The primary endpoint (PE) comprised heart failure (HF)-hospitalization and cardiovascular mortality. The association between NT-proBNP pattern and the PE was assessed by a statistical method that combines a mixed model, describing temporal evolution of NT-proBNP, with Cox proportional hazards regression. Results: Mean age was 67 (SD 13) years, 72% were men and 27% were NYHA class III-IV. During a median follow-up of 1.0 (IQR 0.6-1.4) years 885 samples (median 3 (IQR 2-5) per patient) were drawn. The PE was reached in 41 patients (16%). Median baseline NT-proBNP was 137 (IQR 50-274) ng/L, which was higher in patients with PE than in those without (297 (IQR 186-687) ng/L vs. 110 (IQR 38-235) ng/L; age- and sex adjusted hazard ratio (HR) for doubling of baseline NT-proBNP: 1.21; 95% CI 1.13-1.30). The median of the last NT-proBNP before a PE was 308 (IQR 201-831) ng/L. Age- and sex adjusted NT-proBNP increased before an event, and this temporal pattern was associated with increased risk of PE: doubling of NT-proBNP over time resulted in 2.09 times increased risk (95% CI 1.71-2.56). Conclusions: Temporal patterns of NT-proBNP are associated with HF-hospitalizations and cardiovascular mortality in CHF patients. NT-proBNP was steady in stable patients, but increased before an event. This pattern was expected based on clinical experience, yet has never been quantified prospectively.
Etiology of the Metabolic Syndrome
Authors: Albert J Miller
Journal: JAMA (2004)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The Effect of Neoplasia on the Turnover of Nucleic Acids Studied with Formate-C14 and Glycine-2-C14
Authors: Anita H. Payne, Lola S. Kelly, Genevieve Beach, Hardin B. Jones
Journal: Cancer Research (1952)

Summary  The incorporation of formate-C 14  and glycine-2-C 14  into DNA of liver, spleen, intestine, and tumor tissue and into cPNA of liver was measured, 4 hours after the administration of the precursor, in male A strain mice bearing transplants of mammary carcinoma or sarcoma A274. An increase in the specific activity was observed in the liver and spleen DNA of tumor-bearing mice as compared to the DNA of the same tissues from control mice. The specific activity of the DNA of the intestine was lower in all the tumor-bearing mice than the controls. The liver cPNA specific activity was essentially the same in the mice with tumor transplants as in the control mice.
RLIM inhibits functional activity of LIM homeodomain transcription factors via recruitment of the histone deacetylase complex
Authors: Ingolf Bach, Concepción Rodriguez-Esteban, Catherine Carrière, Anil Bhushan, Anna Krones, David W. Rose, Christopher K. Glass, Bogi Andersen, Juan Carlos Izpisúa Belmonte, Michael G. Rosenfeld
Journal: Nature Genetics (1999)
The Public Health Act of 1848
Authors: R. Alderslade
Journal: BMJ (1998)

Editorial p 550 Recent advances p 584 Education and debate pp 587-98 

The 1848 Public Health Act is 150 years old. Its context, origins, content, and compromises are extensively reviewed in this issue by Hamlin and Sheard (p 587).1 It was an exercise in effective politics, technically remarkably well informed, yet also an imaginative legislative attempt to deal with some still very current issues. How can the best technical public health competence be created in both the essential aspects of the public health discipline—knowledge and action? How can this technical competence be allied to effective combinations of central and local governance and administration? What is the role of law, and enforcement? How can the multisectoral content of public health be addressed? How can communities and individuals best be involved? How can private and corporate influences be brought on board? Above all, how can public health be made to count? These are formidable questions, yet the act shows what can be achieved with imagination and determination. We need to find these same qualities today if public health is to move centre stage.

There is no doubt that it needs to do so. Internationally health is improving, but not enough.2Although average life expectancy has been increasing throughout the 20th century, three out of four people in the least developed countries today are dying before the age of 50. Within Europe a …
313. Ligand-Specific Multiplex Gene Switch Expression in a Mouse Model
Authors: David W. Potter, Mohan B. Kumar, Martha A. DiPietro, Subba R. Palli
Journal: Molecular Therapy (2004)

The ecdysone receptor (EcR)-based gene switch is used to regulate gene expression in a ligand-dependent manner. Gene switches may have utility in human gene therapies that require a specifically regulated level of gene expression, where it is desirable to terminate the therapy when it is no longer needed, or where continuation of the therapy would be unsafe. In addition, multiplexed gene switches allow for the differential regulation of several genes simultaneously. These EcR-based switches are comprised of EcR fused to a GAL4 DNA binding domain, and a chimera of human and insect retinoid X receptor fused to a VP16 activation domain (pVP16-Hs-LmRXR), which regulates a reporter gene that is placed under the control of a 6GAL4 response element and a transthyretin minimal promoter (p6xGAL4RE-TTR-SEAP). Three multiplex gene switches have been developed by mutating the EcR ligand-binding domain in a site-specific manner. Each switch shows specificity for either diacylhydrazines (DAH), tetrahydroquinolines (THQ) or ecdysteroid (EcD) ligands, and are not cross-activated by the other chemotypes. In mouse electroporation studies, a switch based on a V96T/N119F double mutant of EcR showed high specificity for EcD (Ponasterone A, PonA) but was completely refractory toward both DAH (GSTM-E) and THQ (RG-120499) ligands. Likewise, another double mutant of EcR, V128F/A110P, showed specificity toward THQ, but was refractory toward DAH (GSTM-E) and EcD (PonA) ligands. A third gene switch that uses A110P mutant of EcR was sensitive to GSTM-E ligand but not to either EcD (PonA) or THQ (RG-120499) ligands. A dual switch containing V96T/N119F and V128F/A110P EcR double mutants were used to demonstrate the simultaneous regulation of two genes in vivo.