tbuckley/cabot-search huggingface dataset:
Motives for Neonaticide—Reply
Authors: Eric Braverman
Journal: JAMA (2003)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Abstract 17584: Pulmonary Artery Systolic Pressure Independently Predicts All-Cause Mortality in Patients with Coronary Artery Disease Irrespective of a Diagnosis of Heart Failure
Authors: Nima Ghasemzadeh, Raghda Alanbari, Salim Hayek, Mosab Awad, Mohamed Khayata, Bushra Alzaraneh, Hatem Al Kassem, Graham Smith, Saket Kumar, Md Saon, Shuai Zheng, Adithya K Yadalam, Christella Dhammaputri, Aisha Tabba, Javed Butler, Laurence S Sperling, Arshed A Quyyumi
Journal: Circulation (2014)

Background: Elevated pulmonary artery systolic pressure (PASP) is associated with a worse outcome in heart failure (HF), but the prognostic role of PASP in patients with coronary artery disease (CAD) remains unknown. Methods: 863 patients with known or suspected CAD (age: 64±13 years, 62% male) enrolled in the Emory Cardiovascular Biobank were followed for a median 455 days for all-cause death. Transthoracic echocardiographic parameters included measurement of left ventricular ejection fraction (LVEF, range: 5-80%) and diastolic function parameters. Youden’s index from the receiver operating curve analysis was used to determine the best discriminatory cutoff for PASP (cutoff=43 mmHg). Cox regression was performed to determine independent predictors of mortality. Results: 88 (10%) subjects died during follow-up. PASP correlated with left ventricular ejection fraction (LVEF, N=644, r=-0.20, p&lt;0.0001), C-reactive protein (CRP, N=539, r=0.12, p=0.004), and mitral valve inflow E/A ratio (N=359, r=0.32, p&lt;0.0001), mitral valve deceleration time (N=260, r=-0.16, p=0.007),and left atrial size (LAs, N=694, r=0.25, p&lt;0.0001). High PASP predicted incident mortality in a model adjusted for age, gender, diabetes, hypertension, dyslipidemia, smoking, glomerular filtration rate, CRP, heart failure, Gensini angiographic severity score, as well as aspirin, statin, beta-blocker, and angiotensin converting enzyme-inhibitor use (HR: 3.3, p=0.000001). The association of PASP with death was independent of LVEF (HR=3.2, p=0.00002). Thus, high PASP also predicted mortality in subjects with LVEF&gt;50% and no history of HF (HR: 4.7, p=0.004). In separate models, this association was also independent of LAs and E/A. Conclusion: High PASP &gt;43 mmHg is an independent predictor of mortality in patients with CAD even in those with preserved LVEF without HF. Whether high PASP predicts future development of HF and hospitalization for HF exacerbation needs to be investigated.
Abstract P1-11-13: An evaluation of mobile mammography outreach in urban and rural communities
Authors: Lauren Steward, Susan Kraenzle, Bettina Drake, Sarah Lyons, Melody Goodman
Journal: Cancer Research (2015)

Abstract Background: Mobile mammography has been used to reach underserved women in a diverse number of settings. In this work, we demonstrate similarities and differences between rural and urban communities served by a single mobile mammography unit (MMU) affiliated with a comprehensive cancer center in Missouri. Methods: An outreach registry of patients serviced by the MMU was created and includes data from medical records and responses to a brief questionnaire completed at each visit. Data was examined by point of care (urban/rural) to assess the efficacy of mobile mammography as an outreach strategy in each of these environments. Bivariate analyses were used to examine the relationships between demographic characteristics such as age, income, race/ethnicity, education, employment status, marital status, insurance status, and living environment proxy. Results: Between 2006 and 2013, 9480 women received their care on the mobile mammography van. The sample was stratified by point of care (urban vs. rural) served, with majority of the women (86%) residing in urban/suburban St. Louis City/County, and 14% in rural regions. Urban zip codes had a lower percentage of women with income greater than $20,000 (12% v. 21%) and higher percentage of women with income less than $10,000 (49% v. 37%) in comparison to rural communities(p=0.01). There were higher proportions of black women in urban communities (63%) compared to rural communities (10%; p&amp;lt;0.001). Almost half (47%) the women that received mobile mammography in rural zip code were married compared to less than a quarter of women from urban zip codes (24%; p&amp;lt;0.001). Rural communities (83%) had a higher percentage of uninsured women compared to urban communities (67%; p&amp;lt;0.001). Women in urban and rural communities were similar in respect to age, employment status, and education. Conclusions: Mobile mammography has the potential to reach a large population of women with limited educational, financial, and healthcare resources. Future studies will be needed to determine if increasing the range and extent of mobile units, such as this one, would be effective in increasing the screening rates of not only women in Missouri, but also in other portions of this country. Citation Format: Lauren Steward, Susan Kraenzle, Bettina Drake, Sarah Lyons, Melody Goodman. An evaluation of mobile mammography outreach in urban and rural communities [abstract]. In: Proceedings of the Thirty-Seventh Annual CTRC-AACR San Antonio Breast Cancer Symposium: 2014 Dec 9-13; San Antonio, TX. Philadelphia (PA): AACR; Cancer Res 2015;75(9 Suppl):Abstract nr P1-11-13.
Entwicklung und Bibliographie der pathologisch-anatomischen Abbildung.
Authors: Edgar Goldschmid
Journal: JAMA (1926)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Abstract 3045: Procedural and 30-day Outcomes Following Transcatheter Aortic Valve Implantation using the Third Generation (18F) CoreValve Revalving® System - Results from the Multicenter, Expanded Evaluation Registry 1 year after Being CE Mark Approved, on Behalf of all Actively Participating Centers
Authors: Nicolo Piazza, Eberhard Grube, Ulrich Gerckens, Peter den Heijer, Alex Linke, Olev Luha, Angelo Raimondo, Giampaolo Ussia, Peter Wenaweser, Jean-Claude Laborde, Peter de Jaegere, Patrick W. Serruys
Journal: Circulation (2008)

Background: Over 2000 transcatheter aortic valve implantations (TAVI) have been performed worldwide by means of two differing technologies. Initial reports, limited by the initial learning curve and small sample size, documented rates of procedural success and 30-day mortality in three-quarters and more than one-tenth of patients, respectively. Objective: To describe the procedural performance and 30-day outcomes following implantation using the 18F CoreValve Revalving System (CRS) as part of the multicenter, expanded evaluation registry, 1-year after obtaining CE mark approval. Methods: Patients with symptomatic severe aortic stenosis and logistic EuroSCORE ≥ 15%, or age ≥ 75 years, or age ≥ 65 years associated with pre-defined risk factors, and for whom a physician proctor and a clinical specialist were in attendance during the implantation and who collected the clinical data, were included. Results: From April 2007, to April 2008, 646 patients with a mean age of 81± 6.6 years, mean aortic valve area 0.6 ± 0.2 cm2, and logistic EuroSCORE of 23.1± 13.8% were recruited. After valve implantation, the mean transaortic valve gradient decreased from 50.4 ± 16.8 to 3.2 ± 5.2 mmHg. Only one percent of patients had paravalvular aortic regurgitation ≥ grade 2. The rate of procedural success was 97%. The procedural mortality rate was 1.5%. At 30 days, the all-cause mortality rate (i.e. including procedural mortality) was 8% and the combined rate of death, stroke and myocardial infarction was 9.3%. Conclusion: The results of this study demonstrate a high rate of procedural success and low rate of 30-day mortality in a large cohort of high-risk patients undergoing TAVI with the CRS self-expanding aortic valve prosthesis.
Long-Term &lt;italic&gt;In Vitro&lt;/italic&gt; Cultivation of Some Mouse Ascites Tumors: Ehrlich Ascites Carcinoma&lt;xref ref-type="fn" rid="FN1"&gt;2&lt;/xref&gt;&lt;xref ref-type="fn" rid="FN2"&gt;3&lt;/xref&gt;
Authors: Relda Cailleau, Françcoise Costa
Journal: JNCI Journal of the National Cancer Institute (1961)

Ehrlich ascites tumor cells have been grown for more than a year in tissue culture. Changes in morphology, cell size, and chromosome number occurred with variations in the media used. Cells grown on fetal calf serum were predominantly small and spindle-shaped with a chromosome number ranging around a median of 65. Cells grown on ascitic fluid medium and later cloned were frequently multinucleate, ameboid in shape, larger, and often contained a higher number of chromosomes. Tissue-culture strains of cells, when injected at a level of 105 cells or higher, produced characteristic ascites tumors in mice even after 36 transfers and 9 months' growth in vitro. Doses of 103 cells in general produced very few tumors (less than 20%) and apparently induced a high degree of resistance against a subsequent lethal dose of 105 tissue-culture strain cells. Protection against the mouse-grown Ehrlich ascites cells was less marked, but a significant increase in survival time occurred.
Pharmacogenetic screening to prevent carbamazepine-induced toxic epidermal necrolysis and Stevens-Johnson syndrome: a critical appraisal
Authors: K. Wu, N.J. Reynolds
Journal: British Journal of Dermatology (2011)

Journal Article Pharmacogenetic screening to prevent carbamazepine‐induced toxic epidermal necrolysis and Stevens–Johnson syndrome: a critical appraisal Get access K. Wu, K. Wu Department of Dermatology, Royal Victoria Infirmary, Newcastle upon Tyne, U.K Search for other works by this author on: Oxford Academic Google Scholar N.J. Reynolds N.J. Reynolds Department of Dermatology, Royal Victoria Infirmary, Newcastle upon Tyne, U.KDermatological Sciences, Institute of Cellular Medicine, Newcastle University Medical School, Newcastle upon Tyne NE2 4HH, U.K Nick J. Reynolds. E‐mail: n.j.reynolds@ncl.ac.uk Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 166, Issue 1, 1 January 2012, Pages 7–11, https://doi.org/10.1111/j.1365-2133.2011.10754.x Published: 01 January 2012
Formation in isolated rat liver microsomes and nuclei of benzo(a)pyrene metabolites that bind to DNA.
Authors: B Jernström, H Vadi, S Orrenius
Journal: Cancer Research (1976)

The hepatic nuclear fraction isolated from 3-methylcholanthrene (MC)-treated rats contained enhanced levels of cytochrome P-450 and aryl hydrocarbon hydroxylase [benzo(a)pyrene (BP) monooxygenase], whereas the activities of epoxide hydrase and reduced nicotinamide adenine dinucleotide phosphate-cytochrome c reductase and the concentration of cytochrome b5 were not altered. The metabolite pattern of BP was investigated by using high-pressure liquid chromatography and was found to be similar in nuclei and microsomes from MC-treated rats. After incubation of the nuclear fraction with [3H]BP and reduced nicotinamide adenine dinculeotide phosphate, radioactivity was found to be associated with nuclear DNA and the extent of binding was markedly enhanced by pretreatment of the animals with MC. Binding was strongly inhibited by a-napthoflavone but was not influenced by 1,1,1-trichloropropene-2,3-oxide, an inhibitor of epoxide hydrase. In the presence of microsomes from MC-treated rats, increased binding of BP to DNA was observed in nuclei from both control and MC-treated rats; moreover, when the nuclear DNA was replaced by a corresponding amount of calf thymus DNA, the extent of binding was severalfold enhanced. In contrast to nuclei from control rats, the nuclear fraction from MC-treated rats showed an increase in bound radioactivity when incubated with a microsome-free supernatant, obtained by incubating microsomes from MC-treated rats with [3H]BP. The increase in extent of binding was eliminated in the presence of menadione or alpha-naphthoflavone. It is suggested that under the conditions used here the following different processes may have contributed to the total incorporation of BP products into nuclear DNA: (a) formation of DNA-binding products derived from BP by nuclear aryl hydrocarbon hydroxylase; (b) formation of DNA-binding products from microsomal BP metabolites by nuclear aryl hydrocarbon hydroxylase; and (c) direct transfer of reactive microsomal metabolites to nuclear DNA.
Association Between Vaccines and Neuroinflammation—Reply
Authors: Annette Langer-Gould
Journal: JAMA Neurology (2015)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Neurology HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Neurology journal
Abstract 15894: STAT3 Inhibits Hypoxia-Induced Apoptosis via Post-Translational Modification of GSK-3β and Bad in Mesenchymal Stem Cells
Authors: Yu-Ting Xuan, Yanqing Zhu, Ou-Li Wang, Johnson Rajasingh, Buddhadeb Dawn
Journal: Circulation (2014)

Introduction:  Although STAT3 signaling is known to impact cell death/survival, whether STAT3 plays any specific role in MSC apoptosis remains unclear. Recent studies suggest that phosphorylated STAT3 translocates to mitochondria to regulate apoptosis; however, downstream signaling events remain virtually unknown.   Hypothesis:  STAT3 inhibits MSC apoptosis via mitochondrial signaling.   Methods and Results:  Treatment of MSCs with interleukin-6 (IL-6)+epidermal growth factor (EGF) for 30 min resulted in marked increase in pTyr-STAT3 (1096±104% vs. control), p-GSK-3β (263±24% vs. control), and p-Bad (474±27% vs. control), and caused mitochondrial translocation of pTyr-STAT3. Further, 2 h of hypoxia followed by 2 h of reoxygenation caused an increase in cleaved (active) caspase-9 (506±96% vs. control) and poly (ADP-ribose) polymerase (PARP-1/89 kDa fragment, 793±53% vs. control) in MSCs. These apoptotic changes were inhibited by pretreatment of MSCs with IL-6+EGF for 30 min prior to hypoxia, suggesting that mitochondria-mediated pathway of apoptosis is inhibited. Also, pretreatment of MSCs with STAT3 inhibitor WP1066 blocked IL-6+EGF-induced mitochondrial translocation of pTyr-STAT3 and reversed the inhibitory effects of IL-6+EGF-on hypoxia-induced caspase-9 activation and PARP-1 cleavage. Immunoprecipitation of IL-6+EGF-treated homogenates with anti-pTyr-STAT3 antibodies followed by immunoblotting showed that pTyr-STAT3 physically interacts (co-precipitated) with p-GSK-3β and p-Bad, but not with p-PI3K/p85α (Figure). Importantly, phosphorylated GSK-3β and Bad are known to inhibit mitochondrial apoptosis.   Conclusions:  We conclude that STAT3 functions as a kinase to modulate downstream GSK-3β and Bad that inhibit hypoxia-induced apoptosis in MSCs. These data indicate that pTyr-STAT3 interacts with GSK-3β and Bad, leading to formation of two novel p-STAT3-p-GSK-3β and pSTAT3-p-Bad signaling pathways that regulate cell death.
SHORT P-R INTERVAL WITH PROLONGATION OF QRS COMPLEX AND MYOCARDIAL INFARCTION
Authors: A. Allen Goldbloom, Abraham A. Dumanis
Journal: Annals of Internal Medicine (1946)

Excerpt The increasing number of case reports of the Wolff-Parkinson-White syndrome has served to emphasize the need for reappraisal of the clinical aspects of this entity. Early descriptions assoc...
Human Brain Tumor Transplantation Into Nude Mice2
Authors: William R. Shapiro, George A. Basler, Norman L. Chernik, Jerome B. Posner
Journal: JNCI Journal of the National Cancer Institute (1979)

Seven human brain tumors were transplanted into the brains (6/7 takes) and subcutaneous tissues (7/7 takes) of athymic nude mice. Compared to experimental animal brain tumors, these tumors, taken directly from patients in the operating room and transplanted, grew more slowly in the mice; their growth rates following explant generally paralleled those in the patients. A rough correlation was seen between the degree of the tumor's malignancy and both successful take and rate of growth following explant. The tumors' growth rates increased during serial transplantation after explant. Two tumors developed into long-term serial lines; both came from gliosarcomas. Preliminary chemotherapy experiments with these two lines demonstrated different chemosensitivities. One line was very sensitive to the nitrosoureas and resistant to procarbazine; the other line was more sensitive to procarbazine than to the nitrosoureas. This model permits study of the biologic behavior of human brain tumors growing intracerebrally and subcutaneously in nude mice.
Abstract 12746: Validation of a New Algorithm for Detection of Coronary Artery Disease Using Carotid and Femoral Vascular Ultrasound
Authors: Nabil Alzaeim, Amir Abdelwahab, Essam Baligh
Journal: Circulation (2014)

Background: Atherosclerosis is a systemic disease and patients presenting with atherosclerotic coronary artery disease (CAD) usually have associated vascular disease and the reverse is true. Abdelwahab A. et al study is one of the studies who investigate the relation between the different duplex parameters of the carotid and femoral arteries and the extent of coronary atherosclerosis and they proposed a new algorithm for the detection of significant CAD by using carotid and femoral vascular ultrasound. Objective: To assess the validity and applicability of a new algorithm for detection of significant CAD. Methods: Peripheral arterial duplex evaluation was performed for 97 consecutive patients (65 men and 32 women; mean age 59±4.5 years) undergoing coronary angiography for a variety of indications. The following duplex parameters were determined in all patients : Common carotid and common femoral intima media thickness (IMT), carotid total plaques dimension product (PDP) and carotid-femoral (CARFEM) index which is a combination index of IMT of carotid artery and common femoral artery and total wall thickness of the superficial femoral artery. Results: As the number of affected coronary arteries increased, there was a proportional increase in the mean of Carotid IMT, total PDP and CARFEM Index (P= .025, &lt; 0.001 and 0.017 respectively ). Sensitivity, specificity, positive and negative predictive values of the proposed algorithm were 90.3% 72%, 90.3% and 72% respectively. Conclusion: Carotid and femoral duplex provides an easy non-invasive tool for detection of significant CAD. The proposed step-wise algorithm could be a reliable approach for detection of significant CAD.
Population segmentation to identify priority targets for identification and behaviour change interventions in COPD
Authors: Matt Kearney, Julia Crighton, Kevin Holton, Anne Moger, Robert Winter, Sue Hill
Journal: European Respiratory Journal (2011)

Background:  In England 800,000 people are diagnosed with COPD. 2.7 million have the disease but are undiagnosed. Smoking is the dominant risk factor. Targeted identification of those at increased risk combined with effective behaviour change interventions could significantly reduce the disease burden.   Objectives:  To identify and characterise those population groups in England at greatest risk of COPD in order to maximise the impact of targeted behaviour change interventions.   Methods:  A social marketing methodology was employed. An England-wide audience segmentation based on life-stage, socio-economic and environmental factors was conducted to identify priority segments. Focus groups and interviews with informants in each segment provided a rich understanding of behaviours, attitudes and motivation.   Results:  Three segments (children aged 7-12 and young men and women in routine/manual occupations) were identified as priority targets for prevention. Three further segments (mid-life men and women in routine/manual occupations and older routine/manual smokers) were identified as priority targets for identification of undiagnosed COPD. Two segments (Bangladeshi men and routine/manual parents who smoke) were identified as priority targets for both prevention and identification.   Conclusions:  Targeting priority population segments will maximise the effectiveness of identification and behaviour change interventions in COPD and will ensure efficient use of healthcare resources. The results of this segmentation and insight work have informed development of the national strategy in England for the prevention and early identification of COPD.
Treatment of relapsed leukemia after unrelated donor marrow transplantation with unrelated donor leukocyte infusions
Authors: David L. Porter, Robert H. Collins, Christine Hardy, Nancy A. Kernan, William R. Drobyski, Sergio Giralt, Mary E D Flowers, James Casper, Ann Leahey, Pablo Parker, Rosemarie Mick, Bev Bate-Boyle, Roberta King, Joseph H. Antin
Journal: Blood (2000)