Primary Pulmonary Hypertension: More Light or More Tunnel?
Authors: ALFRED P. FISHMAN
Journal: Annals of Internal Medicine (1981)

Editorials1 June 1981Primary Pulmonary Hypertension: More Light or More Tunnel?ALFRED P. FISHMAN, M.D.ALFRED P. FISHMAN, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-94-6-815 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe designation "primary pulmonary hypertension" refers to an aggregate of disorders with a remarkably uniform clinical picture, even though the initiating and subsequent pathogenetic mechanisms may be quite different. The clinical picture is characterized by evidence of pulmonary hypertension in association with progressive exercise intolerance caused by easy fatigability, undue breathlessness, chest pain, or syncope. Unfortunately, an increase in pulmonary arterial pressure is difficult to detect clinically at an early stage. On the other hand, in the later stages, after characteristic roentgenographic and electrocardiographic changes have occurred, it is often difficult to decide whether the disease is really primary or...References1. WOOD P. Diseases of the Heart and Circulation. Philadelphia: J.B. Lippincott Co.; 1956:839-48. Google Scholar2. WAGENVOORT C. Lung biopsy specimens in the evaluation of pulmonary vascular disease. Chest. 1980;77:614-25. CrossrefMedlineGoogle Scholar3. FISHMAN A. Plexiform lesions. Path Microbiol. 1975;43:242-5. MedlineGoogle Scholar4. KINGDON H, COHEN L, ROBERTS W, and BRAUNWALD E. Familial occurrence of primary pulmonary hypertension. Arch Intern Med. 1966;118:422-6. CrossrefMedlineGoogle Scholar5. FISHMAN A and PIETRA G. Primary pulmonary hypertension. Annu Rev Med. 1980;31:421-31. CrossrefMedlineGoogle Scholar6. GURTNER H. Pulmonary hypertension, "plexogenic pulmonary arteriopathy" and the appetitie depressant drug aminorex: post or propter? Bull Europ Physiopath Respir. 1979;15:897-923. MedlineGoogle Scholar7. MEYRICK B, GAMBLE W, and REID L. Development of crotalaria pulmonary hypertension; hemodynamic and structural study. Am J Physiol. 1980;239:H-692-H-702. Google Scholar8. SENIOR R, BRITTON R, TURINO G, WOOD J, LANGER G, and FISHMAN A. Pulmonary hypertension associated with cirrhosis of the liver and with portacaval shunts. Circulation. 1968;37:88-96. CrossrefMedlineGoogle Scholar9. FISHMAN A. Dietary pulmonary hypertension. Circ Res. 1974;35:657-60. CrossrefMedlineGoogle Scholar10. BOURDILLON P and OAKLEY C. Regression of primary pulmonary hypertension. Br Heart J. 1976;38:264-70. CrossrefMedlineGoogle Scholar11. RUBIN L and PETER R. Oral hydralazine therapy for primary pulmonary hypertension. N Engl J Med. 1980;302:69-73. CrossrefMedlineGoogle Scholar12. REEVES J. Hope in primary pulmonary hypertension? N Engl J Med. 1981;302:112-3. Editorial. CrossrefGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: ALFRED P. FISHMAN, M.D.Affiliations: Cardiovascular-Pulmonary Division Hospital of the University of Pennsylvania Philadelphia, Pennsylvania PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byCardiovascular-Pulmonary Interaction in Chronic Obstructive Pulmonary Disease with Special Reference to the Pathogenesis and Management of Cor PulmonaleThe Pathophysiology and Management of Primary Pulmonary HypertensionPulmonary Angiography in Severe Chronic Pulmonary HypertensionPASCAL NICOD, M. D., KIRK PETERSON, M.D., MICHAEL LEVINE, M.D., HOWARD DITTRICH, M.D., MAURICE BUCHBINDER, M.D., FRANCOIS CHAPPUIS, M.D., KENNETH MOSER, M.D.An unusual case of rapidly progressive primary pulmonary hypertension in childhoodManagement of primary pulmonary hypertension.clinical investigationsCaptopril and Primary Pulmonary HypertensionGEORGE S. HUGHES JR., M.D., R. STEPHEN PORTER, PHARM.D.Primary pulmonary hypertension. 1 June 1981Volume 94, Issue 6Page: 815-817KeywordsBlood pressureDyspneaElectrocardiographyExerciseIschemiaPathogensPulmonary hypertensionSyncope ePublished: 1 December 2008 Issue Published: 1 June 1981 PDF downloadLoading ...