tbuckley/cabot-search huggingface dataset:
Improved Survival With Radial Artery Versus Vein Conduits in Coronary Bypass Surgery With Left Internal Thoracic Artery to Left Anterior Descending Artery Grafting
Authors: Anoar Zacharias, Robert H. Habib, Thomas A. Schwann, Christopher J. Riordan, Samuel J. Durham, Aamir Shah
Journal: Circulation (2004)

Given its proven survival benefit, left internal thoracic artery to left anterior descending (LITA-LAD) grafting has become a fundamental part of CABG. This grafting also led to increased use of other arterial conduits, of which the radial artery is most popular. Whether radial grafting improves survival beyond that achieved by LITA-LAD alone is not known.We compared 6-year outcomes in propensity-matched CABG-LITA-LAD patients (925 each) divided into those with > or =1 radial grafts and those with vein-only grafting. Matched patients had essentially identical demographics, comorbidities, coronary disease, and operative data. Perioperative outcomes, including death (radial, 11 [1.2%]; vein, 10 [1.1%]), were similar for the 2 groups. Cumulative 0- to 6-year survival was better for radial patients (risk ratio, 0.675), particularly after 3 years (P<0.03). Six-year survival in vein (86.8%) and radial (92.1%) patients indicated 67% greater overall vein mortality. Incidence rates of radial and vein repeated catheterization (190 of 925 [20.5%] versus 199 of 925 [21.5%]) and revascularization (8.8% versus 8.5%) were similar. Angiography data in restudied symptomatic patients showed a trend for greater radial patency. Vein failure (66 of 161 [41%]) was significantly worse than radial failure (46 of 157 [29.3%]) in patients receiving both types of grafts (P=0.039).Using radial as a second arterial conduit in CABG-LITA-LAD as opposed to vein grafting improves long-term outcomes as a result of decreased late deaths, especially after the third postoperative year.
Protective Effect of Influenza Immunization: The "Hong Kong Flu" Epidemic
Authors: James A. Ryan
Journal: JAMA (1969)

<h3>To the Editor:—</h3> In a previous letter toThe Journal(<b>197</b>:153, 1966) we commented upon the protective effect of polyvalent influenza vaccine given to employees of Occidental Life Insurance Company of California in the fall of 1965, as judged by the incidence of disabling respiratory illnesses during an Asian (A2) influenza outbreak in Los Angeles in February and March 1966. The incidence of such illnesses in the immunized group was 7.27% as compared to 13.13% in the nonimmunized employees, indicating a protective effect of about 50%. The annual influenza immunization program has been continued, including the fall of 1968, with the usual polyvalent vaccine, containing the following strains: A2/Japan, A2/Taiwan, A, Al, and B. In December 1968 and January 1969 the Los Angeles area experienced a widespread epidemic of influenza caused by the "Hong Kong" (A2/ Aichi) strain. We again studied our illness absence records to evaluate the degree, if
Identification and molecular characterization of the ‐‐<sup><scp>CAMPANIA</scp></sup> deletion, a novel α°‐thalassemic defect, in two unrelated Italian families
Authors: Raffaele Sessa, Stella Puzone, Massimiliano Ammirabile, Carmelo Piscopo, Leonilde Pagano, Simona Colucci, Paola Izzo, Michela Grosso
Journal: American Journal of Hematology (2009)

Additional Supporting Information may be found in the online version of this article. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
Independent Predictors of Fibrosis in Patients With Nonalcoholic Fatty Liver Disease
Authors: Noreen Hossain, Arian Afendy, Maria Stepanova, Fatema Nader, Manirath Srishord, Nila Rafiq, Zachary Goodman, Zobair Younossi
Journal: Clinical Gastroenterology and Hepatology (2009)
Contemporary Trends in the Pharmacological and Extracorporeal Management of Heart Failure
Authors: Amir Kazory, Edward A. Ross
Journal: Circulation (2008)

Heart failure and chronic kidney disease share a number of risk factors and pathophysiological pathways. These 2 pathological processes coexist in large numbers of patients. Whereas the presence of chronic kidney disease in patients with heart failure adversely influences their survival, cardiovascular disease is the major cause of mortality in individuals with chronic kidney disease. The management of heart failure by cardiologists has recently expanded from pharmacological treatment to extracorporeal strategies; the interaction between (and concurrent use of) these approaches traditionally has been part of nephrology care and training. The purpose of this review is to explore these management strategies from a nephrologic standpoint and cover the pathophysiology of diuretic resistance, new pharmaceutical strategies to induce natriuresis or aquaresis, and the physiological basis and theoretical advantages of fluid removal by nontraditional peritoneal or hemofiltration approaches. This review also focuses on the technical features, safety, and potential risks of dedicated ultrafiltration devices that do not require dialysis staff or facilities and that are now readily available to nonnephrologists.
Medical Education, Hospitals, and Health Care on Taiwan
Authors: H. Ralph Schumacher, R. Palmer Beasley
Journal: Annals of Internal Medicine (1985)

Abroad1 March 1985Medical Education, Hospitals, and Health Care on TaiwanH. RALPH SCHUMACHER JR., M.D., R. PALMER BEASLEY, M.D.H. RALPH SCHUMACHER JR., M.D.Search for more papers by this author, R. PALMER BEASLEY, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-102-3-409 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe Republic of China, on the semitropical, mountainous, 394- by 144-km island of Taiwan and 13 smaller islands, is populated by 19 million people. There are about 270 000 aborigines but the rest of the population is Chinese from early or recent migrations from the mainland. Rapid industrialization has given Taiwan the fourth highest standard of living in Asia (after Japan, Singapore, and Hong Kong) and a per capita income of about $3000 per year. There is virtually universal literacy.This increasingly Westernized society was greatly influenced by American medicine after World War II. Despite the severing of official relations...References1. Health Statistics, 1982. Taipei, Republic of China: General Health Statistics National Health Administration; 1983. Google Scholar2. HSIEH H. An overview of medical education in Taiwan. Taiwan Review. 1983;Winter:10-17. Google Scholar3. PIERSONBLUMENTHALWATT RSJ eds. The Future of Health Services in Taiwan, R.O.C. New York: American Bureau for Medical Advancement in China; 1982:167. Google Scholar4. ORIENT J. A critique of Western medical commentary on the Peoples Republic of China. Arch Intern Med. 1984;144:106-9. CrossrefMedlineGoogle Scholar5. SCHUMACHER H. Rheumatology and the rheumatic diseases in the Republic of China [Editorial]. J Rheumatol. 1982;9:164-71. Google Scholar6. SCHUMACHERCHANGCHOULEECHEN HSCCS. Cushing's syndrome caused by adulteration of herbal medications. Clin Rheum Pract. 1983;1:183-5. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byCarpe Diem: The Taiwanese health care reform 1 March 1985Volume 102, Issue 3Page: 409-410KeywordsChinese peopleHealth careLiteracyMedical education Issue Published: 1 March 1985 PDF downloadLoading ...
Evaluating Benign and Malignant Musculoskeletal Lesions With Radionuclide Angiography and SPECT Using Tc-99m MIBI
Authors: Koichi Ishiyama, Noriaki Tomura, Kyoji Okada, Hiroyuki Nagasawa, Ryuji Sashi, Kazufumi Sasaki, Kimihiko Sato, Jiro Watarai
Journal: Clinical Nuclear Medicine (2005)

Purpose: The purpose of this study was to evaluate the use of radionuclide angiography and single photon emission computed tomography (SPECT) using Tc-99m hexakis-2-methoxyisobutylisonitrile (Tc-99m MIBI) for analyzing musculoskeletal lesions. Materials and Methods: Radionuclide angiography and SPECT using Tc-99m MIBI were performed in 36 patients with various soft tissue and bone pathologies (18 benign and 18 malignant lesions). The ratio of the counts of the lesion to that of the contralateral normal area was calculated from the region of interest drawn on the MIBI scan. The MIBI-uptake ratio was calculated using SPECT and the MIBI-perfusion index was calculated using radionuclide angiography. Results: The MIBI-uptake ratio in malignant lesions (4.80 ± 4.43) was significantly higher (P < 0.05) than that in benign lesions (1.83±2.48). The sensitivity, specificity, accuracy, positive predictive value, and negative predictive value of the MIBI-uptake ratio for malignant lesions were 72%, 83%, 78%, 81%, and 75%, respectively. The MIBI-perfusion index in malignant lesions (17.68 ± 21.19) was significantly higher (P < 0.05) than that in benign lesions (2.25 ± 2.56). The sensitivity, specificity, accuracy, positive predictive value, and negative predictive value of the MIBI-perfusion index for malignant lesions were 87%, 75%, 81%, 77%, and 86%, respectively. Conclusions: The MIBI-uptake ratio and MIBI-perfusion index using Tc-99m MIBI can yield important additional information with which to differentiate musculoskeletal lesions.
Unusual Cause of Severe Upper Gastrointestinal Hemorrhage Treated Using a Simple Endo-Loop Technique
Authors: A. Nowak, H. Botdys, T. Marek, M. Kajor
Journal: Endoscopy (2001)

The endo-loop technique appears to be a very promising and useful tool in the control of gastrointestinal bleeding. We report a case of successful treatment of severe gastrointestinal hemorrhage from the duodenum.
Acute lymphoblastic leukemia with TEL-AML1 fusion has lower expression of genes involved in purine metabolism and lower de novo purine synthesis
Authors: Gianluigi Zaza, Wenjian Yang, Leo Kager, Meyling Cheok, James Downing, Ching-Hon Pui, Cheng Cheng, Mary V. Relling, William E. Evans
Journal: Blood (2004)
Remarks on Some Current Medical Topics
Authors: S. W. Sibley
Journal: BMJ (1877)

profession, women are, in my opinion, shut out by physical incapacity, REMA K S and, handicapped heavily as they are by nature, they would stand but little chance of success in competition with men.How is it possible ON for a woman on a rough and perhaps wintry night to ride some five or SOME CURRENT MEDICAL TOPICS: six miles in an exposed country, to visit a patient who may require at the end of such a journey a doctor with clear judgment and a steady BEING THE hand?It may b6 answered that women wo'uld not undertake the President's Address delivered at the Annual Meetin~r of the Metro.politanordinary responsibilities of practice, but would devote themselves to Couinties Branch, _7uly 24th, i877.
Percutaneous excimer laser coronary angioplasty of lesions not ideal for balloon angioplasty.
Authors: S L Cook, N L Eigler, A Shefer, T Goldenberg, J S Forrester, F Litvack
Journal: Circulation (1991)

BACKGROUND Excimer laser coronary angioplasty is a new, investigational technique for treating coronary artery stenoses. Initial reports have demonstrated acute efficacy and relative safety of this procedure, but have not addressed the effect of lesion type on acute success and complication rates. METHODS AND RESULTS In the first 100 patients undergoing percutaneous excimer laser coronary angioplasty at our institution, acute laser success was obtained in 84% and procedural success was obtained in 94%. There were six acute closures during laser angioplasty and one myocardial infarction. Two patients required emergency coronary bypass surgery. Sixty-five percent of patients had lesions not ideal for balloon angioplasty because of lesion morphology (tubular, diffuse, or chronic total occlusion) or ostial location. There were 10 tubular stenoses, 29 diffuse lesions, 18 chronic total occlusions, and eight ostial lesions, including five aorto-ostial lesions. In this nonideal subgroup, the acute success rate with laser was 86% (72% of chronic total occlusions and 91% of non-totally occluded lesions), and the procedural success rate was 94%. There were three acute occlusions during laser angioplasty but no myocardial infarctions, emergency bypass surgeries, or deaths. One coronary artery perforation occurred without clinical sequelae. Laser angioplasty was successful in four of six lesions (67%) in which balloon angioplasty had failed. Laser success was obtained in 10 of 11 (91%) moderately or heavily calcified stenoses. Eight eccentric lesions and two lesions on bends were successfully treated without dissection or perforation. No side branch occlusions occurred in the 15 patients in whom one or more major branches originated within the lesion treated. Adjunctive balloon angioplasty was performed in 47% of cases, usually to obtain a larger final luminal diameter. Need for adjunctive balloon angioplasty decreased to 36% after a larger (2.0 mm) laser catheter became available. Twenty-eight percent of the 105 lesions treated were American College of Cardiology/American Heart Association classification type A, 47% were type B, and 25% were type C. Laser and procedural successes were obtained in 83% and 97% of type A, 88% and 96% of type B, and 85% and 88% of type C lesions, respectively. CONCLUSIONS In our initial experience, excimer laser angioplasty was found to be acutely effective and safe therapy for lesions identified as not ideal for balloon angioplasty. This technique may provide a useful adjunct or alternative to balloon angioplasty in selected patients.
Abstract LB-50: Identification and functional analysis of p53MRA as a novel p53 target gene.
Authors: Yuki Funauchi, Chizu Tanikawa, Paulisally Hau Yi Lo, Yusuke Nakamura, Koichi Matsuda
Journal: Cancer Research (2013)

Abstract Identification and characterization of p53-target genes are critical step for the understanding of tumor suppression mechanisms. So far, we have isolated a number of p53 target genes such as p53AIP1, p53R2, p53RDL1, XEDAR and PADI4, and revealed molecular mechanisms by which p53 regulate human carcinogenesis. Here we identified p53MRA (p53-inducible mitochondrial regulator of apoptosis) as a novel p53 target gene that play an important role in an apoptotic pathway through a cDNA microarray analysis using mRNAs isolated from U373MG cells ectopically expressed p53. p53MRA mRNA and protein expression was remarkably induced by ectopic expression of p53 but not by that of LacZ. We also found that adriamycin treatment remarkably induced p53MRA expression in HCT116 colorectal cancer cells in a p53 dependent manner. Subsequently, we surveyed the genomic sequence of the p53MRA gene and found putative p53-binding region within the first intron. Luciferase assay using reporter vector containing this putative p53-binding region revealed that co-transfection of wild-type p53 expressing plasmid enhanced the luciferase activity more than 10-fold. On the other hand, substitution of nucleotides within putative p53-binding region completely diminished the luciferase activity, indicating that p53 regulates p53MRA expression through this p53-binding region. To further investigate the role of p53MRA on tumor cell growth, we treated HCT116 cells with adriamycin 36h after transfection with sip53MRA or siEGFP. As a result, treatment with sip53MRA remarkably increased cell viability to the extent similar to that with sip53. Taken together, p53MRA is novel p53 target gene which plays an important role in the p53-mediated apoptotic pathway. Citation Format: Yuki Funauchi, Chizu Tanikawa, Paulisally Hau Yi Lo, Yusuke Nakamura, Koichi Matsuda. Identification and functional analysis of p53MRA as a novel p53 target gene. [abstract]. In: Proceedings of the 104th Annual Meeting of the American Association for Cancer Research; 2013 Apr 6-10; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2013;73(8 Suppl):Abstract nr LB-50. doi:10.1158/1538-7445.AM2013-LB-50
Abstract 3485: Efficient transfection of cancer cell lines using the 4D-NucleofectorTM System
Authors: Jenny Schroeder, Ludger Altrogge, Elke Lorbach, Srinivasan Kokatam, Sabine Schaepermeier, Meike Weigel, Gina Andretta-Beu, Stefanie Buesch, Tamara Grabeck, Alexandra Krumnow, Sonja Spicker, Sampada Kallol, Preeti Kapoor, Andrea Toell
Journal: Cancer Research (2014)

Abstract Cell lines isolated from tumors are an important tool to study cancer in vitro. They can be used for drug development as well as for understanding the basic mechanisms underlying cancer. Transfection of cancer cell lines with different molecules like plasmid DNA, siRNA or mRNA is often an integral part for this kind of research. Lonza's 4D-Nucleofector™ System is a modular system for the efficient transfection of primary cells and cell lines with a variety of substrates including plasmid DNA and siRNA. The 4D-Nucleofector™ X Unit supports the Nucleofection™ in two different formats. The aluminum-free 20µl Nucleocuvette™ Strip allows the transfection of low cell numbers down to 2x104 cells per reaction. As 16 reactions can be performed in parallel it is well suited for optimizing Nucleofection™ Conditions for cells lacking a ready-to-use Optimized Protocol. For higher cell numbers of up to 2x107 cells per reaction the same Nucleofection™ Conditions can be applied in the 100μl single Nucleocuvette™ Vessel. For higher throughput needs the 96-well Shuttle™ Add-on can be connected to the 4D-Nucleofector™ System. With this add-on six 20µl Nucleocuvette™ Strips can be processed in parallel allowing for screening applications or accelerating the optimization of transfection parameters for many cell types. In this study we used the 4D-Nucleofector™ System in combination with the 96-well Shuttle™ Add-on for optimizing transfection conditions for multiple cancer cell lines. An exemplary optimization process is depicted for the human prostate carcinoma cell line DU 145 and for the human colorectal adenocarcinoma cell line COLO 205. Optimization steps included the selection of the appropriate Nucleofector™ Solution, Nucleofector™ Program and plasmid DNA concentration. Transfection parameters were thereby optimized for a variety of adherent and non-adherent human cancer cell lines resulting in transfection efficiencies of up to 99%; while maintaining high cell viability. Citation Format: Jenny Schroeder, Ludger Altrogge, Elke Lorbach, Srinivasan Kokatam, Sabine Schaepermeier, Meike Weigel, Gina Andretta-Beu, Stefanie Buesch, Tamara Grabeck, Alexandra Krumnow, Sonja Spicker, Sampada Kallol, Preeti Kapoor, Andrea Toell. Efficient transfection of cancer cell lines using the 4D-NucleofectorTM System. [abstract]. In: Proceedings of the 105th Annual Meeting of the American Association for Cancer Research; 2014 Apr 5-9; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2014;74(19 Suppl):Abstract nr 3485. doi:10.1158/1538-7445.AM2014-3485
Mechanism of U wave and polymorphic ventricular tachycardia in a canine tissue model of Andersen–Tawil syndrome
Authors: H MORITA, D ZIPES, S MORITA, J WU
Journal: Cardiovascular Research (2007)

Objective Andersen–Tawil syndrome (ATS) is a channelopathy affecting inward rectifier potassium IK1 with QT prolongation, large U waves, and frequent ventricular tachycardia (VT). Although ATS is clinically defined and genetically identified, its electrophysiological mechanism is still unclear, and thus, was the subject of the current study.
A large-scale screen for coding variants predisposing to psoriasis
Authors: Huayang Tang, Xin Jin, Yang Li, Hui Jiang, Xianfa Tang, Xu Yang, Hui Cheng, Ying Qiu, Gang Chen, Junpu Mei, Fusheng Zhou, Renhua Wu, Xianbo Zuo, Yong Zhang, Xiaodong Zheng, Qi Cai, Xianyong Yin, Cheng Quan, Haojing Shao, Yong Cui, Fangzhen Tian, Xia Zhao, Hong Liu, Fengli Xiao, Fengping Xu, Jianwen Han, Dongmei Shi, Anping Zhang, Cheng Zhou, Qibin Li, Xing Fan, Liya Lin, Hongqing Tian, Zaixing Wang, Huiling Fu, Fang Wang, Baoqi Yang, Shaowei Huang, Bo Liang, Xuefeng Xie, Yunqing Ren, Qingquan Gu, Guangdong Wen, Yulin Sun, Xueli Wu, Lin Dang, Min Xia, Junjun Shan, Tianhang Li, Lin Yang, Xiuyun Zhang, Yuzhen Li, Chundi He, Aie Xu, Liping Wei, Xiaohang Zhao, Xinghua Gao, Jinhua Xu, Furen Zhang, Jianzhong Zhang, Yingrui Li, Liangdan Sun, Jianjun Liu, Runsheng Chen, Sen Yang, Jun Wang, Xuejun Zhang
Journal: Nature Genetics (2013)
Patency Evaluation of a LeVeen Shunt Using 99mTc-Sulfur Colloid
Authors: BRIAN R. J. WILLIAMSON, MATTHEW J. LAMBERT, C DAVID TEATES, STUART T. BRAY, JEAN A. WAKEFIELD
Journal: Clinical Nuclear Medicine (1978)

The LeVeen shunt has proved valuable in relieving intractable ascites. It is however subject to failure in about 5–8% of cases.1,2,3 To our knowledge there are only three reports in the literature describing the use of nuclides to assess patency; two using 99mTc-sulfur colloid1,2 and one using 99mTc-albumin.4 The purpose of this paper is to add our experience to the data currently published and stress that late liver visualization may occur with an obstructed shunt.
Bridging to transplant with azacitidine in juvenile myelomonocytic leukemia: a retrospective analysis of the EWOG-MDS study group
Authors: Annamaria Cseh, Charlotte M. Niemeyer, Ayami Yoshimi, Michael Dworzak, Henrik Hasle, Marry M. van den Heuvel-Eibrink, Franco Locatelli, Riccardo Masetti, Markus Schmugge, Ute Groß-Wieltsch, Andrea Candás, Andreas E. Kulozik, Lale Olcay, Meinolf Suttorp, Ingrid Furlan, Brigitte Strahm, Christian Flotho
Journal: Blood (2015)
Successful Treatment of Quinidine and Procaine Amide Intoxication
Authors: Fred Wasserman, Leonard Brodsky, Morris M. Dick, John H. Kathe, Paul L. Rodensky
Journal: New England Journal of Medicine (1958)

EARLIER observations from this laboratory demonstrated in the laboratory animal the efficacy of molar sodium lactate in reversing toxic electrocardiographic and blood-pressure changes resulting from quinidine and procaine amide.1 2 3 The purpose of this paper is to report the successful clinical application of these findings.Case ReportsCase 1. N.D., a 66-year-old man, was admitted to the Veterans Administration Hospital, Coral Gables, Florida, on January 18, 1958, because of chest pain. On the evening before admission, substernal chest pain and palpitation, without other cardiovascular symptoms, developed. There was no previous history of heart disease. On admission, the rhythm was regular, with . . .
(9) Multiple histiocytomata and systemic lupus erythematosus
Authors: M. J. Cheesbrough, B.R. Allen
Journal: British Journal of Dermatology (1978)

Journal Article (9) Multiple histiocytomata and systemic lupus erythematosus Get access M. J. Cheesbrough, M. J. Cheesbrough General Hospital, Nottingham Search for other works by this author on: Oxford Academic Google Scholar B.R. Allen B.R. Allen General Hospital, Nottingham Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 99, Issue s16, 1 December 1978, Pages 34–35, https://doi.org/10.1111/j.1365-2133.1978.tb15231.x Published: 01 December 1978