tbuckley/cabot-search huggingface dataset:
An MRI study of the corpus callosum in autism
Authors: Joseph Piven, James Bailey, Bonnie J. Ranson, Stephan Arndt
Journal: American Journal of Psychiatry (1997)

The purpose of this study was to examine the size of subregions of the corpus callosum in autistic individuals.The areas of three subregions (anterior, body, and posterior) of the corpus callosum were examined on midsagittal magnetic resonance images of 35 autistic subjects whose mean age was 18 years and 36 healthy comparison subjects matched on age and IQ.After controlling for total brain volume, gender, and performance IQ, the authors detected a significantly smaller size of the body and posterior subregions of the corpus callosum in the autistic individuals.In the context of recent reports of increased brain size in autism, several possible mechanisms are considered in exploring the significance of a smaller relative size of the corpus callosum in autism.
Floating Kidneys
Authors: Patrick O Myers, Gilles Chassot
Journal: New England Journal of Medicine (2007)

A 48-year-old man with multiple myeloma and a history of a repaired umbilical hernia and four thromboembolic events was admitted for cramping abdominal pain associated with back pain and a weight loss of 5 kg (11 lb) during the previous month. Physical examination showed a distended abdomen and no lower-extremity edema. Laboratory evaluation was notable for a creatinine level of 1.2 mg per deciliter (108 μmol per liter), an albumin level of 3.3 g per deciliter, and normal urinary sediment. Contrast-enhanced computed tomography showed well-defined cystic retroperitoneal masses in which the kidneys appeared to be floating, extending from below the . . .
Abstract 1577: Cardiac Specific Inhibition of Gq Signaling Improves Cardiac Function by Improving Extracellular Remodeling Following Chronic Hypertension
Authors: David M Harris, Heather I Cohn, Xiongwen Chen, Scott M MacDonnell, Maggie Shapiro, Elizabeth Mandel, Steven R Houser, Walter J Koch, Andrea D Eckhart
Journal: Circulation (2006)

Hypertension (HBP) and heart failure are associated with increased plasma levels of norepinephrine and angiotensin II (AngII), which activate Gq coupled receptors. We showed that transgenic mice ex...
Abstract 4104: Organization of Atrial Signals is Critical Prior to Cardioversion of Atrial Fibrillation with Intravenous Flecainide: Insight from Spectral Analysis of Intracardiac Electrograms
Authors: Jiun Tuan, Suman Kundu, Mohamed Jeilan, Faizel Osman, Rajkumar Mantravadi, Peter Stafford, G. Andre Ng
Journal: Circulation (2008)

Introduction &amp; Hypothesis: Studies in catheter ablation of atrial fibrillation (AF) show that an increase in cycle length (CL) and higher organization index (OI) is associated with termination of AF. We hypothesize that similar changes can be seen in chemical cardioversion with Flecainide Methods: Patients who were still in AF at the end of catheter ablation for AF were given intravenous flecainide. OI and dominant frequency (DF) were obtained by Fast Fourier Transform of coronary sinus electrograms over 10s in AF, before and after flecainide infusion. Mean CL was also calculated. Results: 28 patients were identified (18 paroxysmal AF and 10 persistent AF). 8 cardioverted to sinus rhythm (SR) with flecainide. In all patients, mean CL increased from 211 ± 44 ms to 321 ± 85 ms (p &lt;0.001). Mean DF decreased from 5.2 ± 1.03 Hz to 3.6 ± 1.04 Hz (p &lt;0.001). Mean OI was 0.33 ± 0.13 before and 0.32 ± 0.11 after flecainide (p = 0.90). Comparing patients who cardioverted to SR with those who did not, OI post-flecainide was 0.41 ± 0.12 vs 0.29 ± 0.10 (p=0.013) and relative change in OI was 29 ± 33% vs −3.9 ± 27% (p=0.016) respectively. No significant difference was noted in the change in CL and DF in the 2 groups. Logistic regression showed that a greater relative increase in OI (p=0.04), a higher OI post-flecainide (p=0.03) and SR at start of procedure (p=0.03) are independently associated with cardioversion to SR with flecainide. Conclusion: Increase in OI, independent of changes to the CL and DF, appears critical to AF termination with flecainide. The increase in OI may reflect an increase in size and reduction in the number of re-entrant circuits, which together with slowing of atrial activation, result in return to SR.
Abstract 16900: Gene Therapy With Alipogene Tiparvovec Results in Enhanced Post-Prandial Clearance of Low Density Chylomicrons in LPLD Patients
Authors: Andre Carpentier, Frederique Frisch, Sebastien M Labbe, Julie Methot, Claude Gagne, Stephane Dery, Karine Tremblay, Janneke de Wal, Jaap Twisk, Andreas Freidig, Diane Brisson, Daniel Gaudet
Journal: Circulation (2010)

Introduction: Alipogene tiparvovec (Glybera®) is designed to express functionally active LPL in the muscle of lipoprotein lipase deficient (LPLD) patients. It consists of a DNA sequence coding for ...
Abstract 3893: A Novel IKK Inhibitor IMD-0560: Suppresses Chronic Remodeling after Myocardial Ischemia
Authors: Jun-ichi Suzuki, Shin Wakatsuki, Masahito Ogawa, Susumu Muto, Akiko Itai, Mitsuaki Isobe
Journal: Circulation (2008)

Amplification of inflammatory response in the non-infarct area plays an important role in the pathogenesis of ventricular remodeling after myocardial ischemia. Activation of nuclear factor-kappa B (NF-kB) is involved in this amplification through a positive feedback loop of proinflammatory cytokines. We investigated the efficiency of IKK blockade with IMD-0560, a novel inhibitor of IKK, in a rat myocardial ischemia model. Left coronary artery occlusion (28 days) was carried out in Sprague-Dawley rats. The rats were assigned randomly to the two groups: IMD-0560 injection (5mg/kg i.p.) daily for 28 days (MI + IMD group, n=10); vehicle injection (i.p.) daily for 28 days (MI + vehicle group, n=10); and thoracotomy with LAD isolation without ligation (Sham group, n=5). Treatment with IMD-0560 significantly improved cardiac function, as indicated by the preservation of % fractional shortening (vehicle-treated, 20.2±1.5; IMD-0560-treated, 26.7±2.4; P &lt; 0.05), and lower serum brain natriuretic peptide level (vehicle, 0.079±0.040; IMD-0560, 0.033±0.016; P &lt; 0.05). Histological analysis showed that hypertrophy of myocardium was suppressed in the peri-infarct area (vehicle, 756.71±48.57mm2; IMD-0560, 633.35±29.83mm2; P &lt; 0.05), and the thickness of infarct area was maintained (vehicle, 0.890±0.027mm; IMD-0560, 1.136±0.087mm; P &lt; 0.05). The sham group showed no effect. Moreover, in situ zymography showed that matrix metalloproteinase-9 activity was inhibited in the infarct area. We revealed that IMD-0560 is potent in the suppression of chronic ventricular remodeling after myocardial ischemia.
D-Transposition of the Great Arteries
Authors: Juan Villafañe, M. Regina Lantin-Hermoso, Ami B. Bhatt, James S. Tweddell, Tal Geva, Meena Nathan, Martin J. Elliott, Victoria L. Vetter, Stephen M. Paridon, Lazaros Kochilas, Kathy J. Jenkins, Robert H. Beekman, Gil Wernovsky, Jeffrey A. Towbin
Journal: Journal of the American College of Cardiology (2014)
National Efforts to Improve Door-to-Balloon Time
Authors: Elizabeth H. Bradley, Brahmajee K. Nallamothu, Jeph Herrin, Henry H. Ting, Amy F. Stern, Ingrid M. Nembhard, Christina T. Yuan, Jeremy C. Green, Eva Kline-Rogers, Yongfei Wang, Jeptha P. Curtis, Tashonna R. Webster, Frederick A. Masoudi, Gregg C. Fonarow, John E. Brush, Harlan M. Krumholz
Journal: Journal of the American College of Cardiology (2009)
Abstract 13238: C/ebpb Controls Cardiac Growth During Exercise
Authors: Pontus A Bostrom, Nina Mann, Jun Wu, Pablo A Quintero, Eva R Plovie, Rana Gupta, Calum MacRae, Anthony Rosenzweig, Bruce M Spiegelman
Journal: Circulation (2010)

Background: Cardiomyocytes grow in size in response to physiological and pathological stimuli. Several transcriptional pathways regulating pathological hypertrophy have been described, but the mole...
Oculopharyngeal Muscular Dystrophy
Authors: G Tamir, D Hauben
Journal: BMJ (1963)

A rare case of progressive bilateral ptosis with dysphagia in a 70-year-old man is presented. There were similar symptoms in other members of the family. The patient was diagnosed as having oculopharyngeal muscular dystrophy, a rare autosomal dominant disorder involving progressive muscular dystrophy, one of the chronic external ophthalmoplegic syndromes. There had been slowly progressive bilateral ptosis and there was almost no levator palpebra muscular activity left, resulting in extreme head tilt. A sling suspension operation for the ptotic lids, using autogenous fascia lata, was successful. Oculopharyngeal muscular dystrophy is essentially a myogenic disorder. Affected muscles are usually those of the pharynx, causing dysphagia, and the levator palpebra muscles. Rarely are other skeletal muscles involved. The sling operation gives direct support to the dystrophic malfunctioning levator muscles by using the frontalis muscles to raise the ptotic lids, thus improving visual ability.
Abstract 621: MRI-related Heating at Cardiac Pacemaker Leads in vivo
Authors: Peter Nordbeck, Wolfgang R Bauer, Marcus Warmuth, Karl-Heinz Hiller, Peter M Jakob, Oliver Ritter
Journal: Circulation (2009)

Introduction: Currently, MRI is considered a contraindication in pacemaker patients. One main reason is the potential for RF-related heating to appear at pacemaker leads during MRI, as proven in se...
Essentials of Blood Grouping and Clinical Applications.
Authors: K. S. Ranganathan, Alexander S. Wiener
Journal: Annals of Internal Medicine (1968)

This Atlas is a useful supplement to the Atlas of Head and Neck Surgery by Lor6, also published by Saunders.It uses the same concise but clear arrangement as Lore did with the steps of the surgical procedure on one page and drawings illustrating the steps on the opposite page.The material covered includes fractures of the mandible and facial bones, removal and subsequent reconstruction of lesions on the lips and face, the jaws and palate, and floor of the mouth and tongue.The book also includes operations on the temporomandibular joint, the radical neck dissection, removal of congenital cysts of the neck, surgical repair of malformations of the jaw, and salivary gland surgery.The strength of this book is its emphasis on applied anatomy and the orderly way in which the se- quence of the surgical steps is established with drawings and written descriptions.In my opinion its major weak- ness is that although it describes itself as covering the neck, it does not include larynx and pharynx surgery.
The role of proximity, immediacy, and expectancy in frontline treatment of combat stress reaction among Israelis in the Lebanon War
Authors: Z Solomon, R Benbenishty
Journal: American Journal of Psychiatry (1986)

The authors examined the effectiveness of the prevailing treatment doctrine stressing the principles of proximity, immediacy, and expectancy for combat stress reaction among Israeli soldiers in the Lebanon War. Two treatment outcomes were measured: return to military unit and presence of posttraumatic stress disorder. All three treatment principles were associated with a higher rate of return to the military unit. The beneficial effect of frontline treatment was also evidenced by lower rates of posttraumatic stress disorder. The authors suggest that these principles can also be effective in treating other forms of posttraumatic stress disorder.
The Management of Symptoms in Advanced Cancer: Experience in a Hospital-Based Continuing Care Unit
Authors: P J Hoskin, G W Hanks
Journal: Journal of the Royal Society of Medicine (1988)

The treatment received by 158 patients with advanced cancer admitted over one year to the Continuing Care Unit at the Royal Marsden Hospital has been reviewed. The unit is an integral part of the hospital and this is reflected in the fact that 46 patients (29%) received radiotherapy, hormone therapy, chemotherapy or surgery in addition to symptomatic treatment for palliation of troublesome symptoms. One hundred and thirty-one patients received oral morphine in doses ranging from 2.5 mg 4-hourly to 700 mg 4-hourly. Patients with renal or hepatic impairment required lower doses of morphine and there was a highly significant inverse relationship between morphine dose and age. Eighty-five patients (54%) received parenteral diamorphine at some time due to their inability to take oral morphine. One hundred and twenty-three patients (78%) received a co-analgesic drug and anti-emetics were required by 78 patients (49% overall; 56% of those receiving morphine). Transcutaneous electrical nerve stimulation, acupuncture and relaxation were employed in selected patients, and graduated compression sleeves were used to treat lymphoedema. These data highlight the wide range of therapeutic options available to control the symptoms of advanced cancer and also indicate that tumoricidal treatments used in conjunction with symptomatic treatments may have a significant part to play.
Abstract 5430: Obstructive Sleep Apnoea Exacerbates Muscular Sympathetic Nervous Activity in Patients with Metabolic Syndrome
Authors: Ivani C Trombetta, Cristiane M Nunes, Luciano F Drager, Raffael F Fraga, Maria Janieire N Alves, Maria Urbana P Rondon, Maita G Bechara, Edgar T Dias, Ana M Braga, Mateus C Laterza, Geraldo Lorenzi-Filho, Carlos E Negrao
Journal: Circulation (2008)

Obstructive sleep apnoea (OSA) and metabolic syndrome (MetS) independently increases muscular sympathetic nervous activity (MSNA). Unknown is whether OSA has an additive effect on MSNA in patients with MetS. We tested the hypothesis that: OSA would have an additive effect on MSNA in patients with MetS. In addition, we studied whether the increase in MSNA in patients with MetS is associated with alteration in arterial baroreflex sensitivity (BRS). Twenty four patients with MetS diagnosed according ATP-III were divided in two groups: MetS+OSA (n=14) and MetS (n=10). They were matched for age, body mass index, waist circumference, and metabolic profile: OSA was defined by an apnoea/hypopnoea index (AHI)&gt;15 events/hour by polysonography. MSNA was recorded directly from the peroneal nerve using the technique of microneurography. Blood pressure (BP) was monitored on a beat-by-beat basis (Finapress) and heart rate by ECG. BRS was analyzed by spontaneous BP and heart rate fluctuations. AHI was higher (42±9 vs. 7±1 events/h, P =0.0001) and minimum oxygen saturation lower (77±2 vs. 87±1 %, P =0.001) in MetS+OSA patients. Patients MetS+OSA had higher MSNA (55±3 vs. 43±2 bursts/100 beats, P =0.01) and systolic BP (158±4 vs.144±3 mmHg, P =0.01) when compared with patients with MetS without OSA. Further analysis showed that AHI and minimum oxygen saturation have significant correlation with MSNA (r=0.65; P =0.001 and r=−0.48; P =0.017, respectively). Patients with MetS+OSA had lower BRS for increases (7.8±0.9 vs. 13.4 ± 1.4 msec/mmHg, P =0.01) and decreases (7.2±0.9 vs. 13.2 ± 2.0 msec/mmHg, P =0.03) in blood pressure than patients with MetS without OSA. MSNA significantly correlated with BRS during spontaneous increases in blood pressure (r=−0.56, P =0.01). OSA exacerbates MSNA in patients with MetS. In addition, the augmented MSNA in patients with MetS+OSA is associated with reduced BRS. These findings suggest that OSA increases the risk for cardiovascular disease in patients with MetS.
Brief Communication : Adriamycin-Induced Cardiac Damage in the Mouse: A Small-Animal Model of Cardiotoxicity
Authors: Stephen H. Rosenoff, Harry M. Olson, David M. Young, Frieda Bostick, Robert C. Young
Journal: JNCI Journal of the National Cancer Institute (1975)

After one dose of adriamycin, a subacute cardiomyopathy was observed in the mouse by both light and electron microscopy. The microscopic alterations were characterized by single-cell necrosis and mitochondrial degeneration. These lesions were similar to those seen in man and shortly preceded fatal toxicity.
Aldactone With and Without Hydrocortisone: Effects on Carbohydrate Metabolism, Serum Solutes and Lipids, and Urine Steroids
Authors: T S DANOWSKI, J V BONESSI, A C HEINEMAN, C MOSES
Journal: JAMA (1963)

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Mechanisms for Spontaneous Termination of Monomorphic, Sustained Ventricular Tachycardia
Authors: Heiko Schmitt, Andrew L Wit, James Coromilas, Bernd Waldecker
Journal: Journal of the American College of Cardiology (1998)

Objectives. The objective of this study was to determine why sustained ventricular tachycardias (VT) sometimes stop without outside intervention. Background. Sustained, monomorphic VT in patients with ischemic heart disease is often caused by reentrant excitation. These tachycardias can degenerate into rapid polymorphic rhythms or occasionally terminate spontaneously. Methods. Sustained VT was induced by programmed stimulation in dog hearts 4 to 5 days after ligation of the left anterior descending coronary artery. Activation in reentrant circuits in the epicardial border zone of the infarct was mapped using 192 to 312 bipolar electrodes. Results. Spontaneous termination of sustained VT always occurred when the reentrant wave front blocked in the central common pathway in reentrant circuits with a figure-of-eight configuration. Two major patterns of termination were identified from activation maps of the circuits that were not distinguishable from each other on the surface electrocardiogram: 1) Abrupt termination was not preceded by any change in the pattern of activation or cycle length. It could occur at different locations within the central common pathway, was not related to the directions of the muscle fiber orientation and was not caused by a short excitable gap. 2) Termination caused by premature activation (after a short cycle) either resulted from shortening of the functional lines of block around which the reentrant impulse circulated or was caused by wave fronts originating outside the reentrant circuit. In only one episode were oscillations of cycle length associated with termination. Conclusions. The mechanisms for termination of reentry in functional circuits causing VT are different from those in anatomic circuits where oscillatory behavior precedes termination.
Reply
Authors: Jude A. Oben
Journal: Hepatology (2015)

Potential conflict of interest: Nothing to report. We thank Dr. Zou and colleagues for their comment on our recent article.1 The main message of our article was that the sympathetic nervous system (SNS) protects the liver from acute injury. This conclusion was based on evidence that decreasing cathecholamine neurotransmitters reduced hepatic progenitor cell (HPC) accumulation and exacerbated liver injury caused by acetaminophen (APAP), whereas exogenous administration of the cathecholamine, isoproterenol (ISO), reversed these effects. We first showed that the number of HPCs was reduced in dopamine β‐hydroxylase null mice, which lack cathecholamines, and demonstrated that this HPC depletion was reversed by ISO (Fig. 1A). That the effect of ISO was likely mediated by direct actions on HPCs (and not indirectly by ISO‐mediated exacerbation of liver injury) was then shown by studies in cultured 603B cells. ISO increased progenitor cell growth in vitro (Fig. 1D), and this effect was inhibited by the β‐adrenoceptor antagonist, propranolol (PRL; Fig. 1E). In wild‐type mice, ISO alone caused no liver injury, as assessed by alanine transaminase (ALT) and liver histology (Fig. 3A,B). Similarly, ISO did not enhance APAP‐induced liver injury. Rather, ISO markedly reduced liver injury and improved survival of APAP‐treated mice (Fig. 3C,D). These improved outcomes paralleled ISO‐related increases in HPC numbers (Fig. 3E). In contrast, the β‐adrenoceptor antagonist, PRL, clearly worsened APAP‐induced liver injury (Fig. 3F). Performing sympathectomies in control mice before APAP also profoundly worsened APAP‐induced liver injury, such that the mean ALT was approximately 15,000 IU/L (Supporting Fig. 2).
Pediatric Aplastic Anemia and Refractory Cytopenia of Childhood: A Retrospective Single Institutional Analysis to Determine Outcomes and Histomorphological Predictors
Authors: Craig Forester, Sarah E Sartain, Dongjing Guo, Marian Harris, Olga Weinberg, Mark D. Fleming, Wendy B. London, David A. Williams, Inga Hofmann
Journal: Blood (2014)
P0137 : Safety of boceprevir-based triple therapy in HCV cirrhotic patients awaiting liver transplantation. Analysis from a French multicenter, open-label study (ANRS HC29 bocepretransplant)
Authors: H. Fontaine, M. Maynard-Muet, C. Bouix, D. Botta-Fridlund, L. D’Alteroche, F. Conti, G.-P. Pageaux, V. Leroy, S. Métivier, R. Anty, F. Durand, V. Canva, P. Lebray, L. Alric, C. Duvoux, V. Petrov-Sanchez, F. Beaulieux, C. Willems, C. Paul, P. Pradat, J.-C. Duclos-Vallée, D. Samuel
Journal: Journal of Hepatology (2015)