tbuckley/cabot-search huggingface dataset:
Factors Associated With Occupational Sun-Protection Policies in Local Government Organizations in Colorado
Authors: Barbara J. Walkosz, David B. Buller, Peter A. Andersen, Allan Wallis, Mary Klein Buller, Michael D. Scott
Journal: JAMA Dermatology (2015)

Skin cancer prevention remains a national priority. Reducing chronic UV radiation exposure for outdoor workers through sun-safety practices is an important step to help reduce the incidence of skin cancer.To determine the presence of occupational sun-safety policies at local government organizations in a single state.Of 571 potentially eligible local government organizations of Colorado cities, counties, and special tax districts, we enrolled 98 in a randomized pretest-posttest controlled experiment starting August 15, 2010, that evaluated an intervention to promote the adoption of sun-safety policies. We used a policy-coding protocol to evaluate personal sun-protection practices, environmental and administrative controls, and policy directives for sun safety starting February 10, 2011. We report the baseline assessment of the occupational sun-protection policies of these organizations.The presence of an occupational sun-safety policy.Overall, 85 local government organizations (87%) had policies that required personal sun-protection practices, including the use of eyewear, hats, and protective clothing. However, of the 98 responding organizations, only 8 hat policies (8%), 10 eyewear policies (10%), and 7 clothing policies (7%) mentioned sun protection as the intent of the policy. Only cosmopoliteness, operationalized as proximity to an urban area, was associated with the presence of a sun-safety policy (odds ratio, 0.99 [95% CI, 0.98-1.00]; P = .02).Outdoor workers are at increased risk for skin cancer because of long-term exposure to solar UV radiation. Although organizational policies have the potential to increase sun protection in occupational settings, occupational sun-safety policies were uncommon among local governments. Opportunities exist for dermatologists and other physicians to influence occupational sun-safety practices and policies, which are consistent with other safety procedures and could easily be integrated into existing workplace practices.
Bisphosphonate Use and Prevalence of Valvular and Vascular Calcification in Women
Authors: Sammy Elmariah, Joseph A.C. Delaney, Kevin D. O'Brien, Matthew J. Budoff, Jens Vogel-Claussen, Valentin Fuster, Richard A. Kronmal, Jonathan L. Halperin
Journal: Journal of the American College of Cardiology (2010)
COMPLETE HEART BLOCK FROM SCLEROSIS OF THE BUNDLE OF HIS
Authors: Ben R. Heninger, K. L. Dickens
Journal: Annals of Internal Medicine (1936)

Article1 November 1936COMPLETE HEART BLOCK FROM SCLEROSIS OF THE BUNDLE OF HISBEN R. HENINGER, M.D., F.A.C.P., K. L. DICKENS, M.S., M.B.BEN R. HENINGER, M.D., F.A.C.P.Search for more papers by this author, K. L. DICKENS, M.S., M.B.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-10-5-696 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptComplete heart block may result from various types of lesions involving the bundle of His or other parts of the conduction system. Most of the cases of complete heart block reported in the literature were the result of syphilitic gummas. There are on record isolated cases of heart block in which fatty infiltrations have caused auricular-ventricular dissociation; in others, tumors, such as endotheliomas and sarcomas, have been found to destroy the conduction pathways of the bundle. On the other hand, there are numerous cases in which there was clinical heart block, but at autopsy no lesion was found in the...Reference YATERCORNELL WMVH: Heart block due to calcareous lesions of the bundle of His, ANN. INT. MED., 1935, viii, 777-789. LinkGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: New Orleans, Louisiana*Received for publication October 5, 1935.From the Departments of Medicine and Anatomy, Louisiana State University Medical Center, New Orleans, La. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 November 1936Volume 10, Issue 5Page: 696-701KeywordsAutopsy pathologyClinical pathologyHeartLesionsSarcoma ePublished: 1 December 2008 Issue Published: 1 November 1936 PDF downloadLoading ...
Abstract 144: Post-myocardial Infarction Therapeutics Using Cardiovascular Progenitor Cells (PC) Derived from Induced Pluripotent Stem Cells (iPSC)
Authors: Yigang Wang
Journal: Circulation Research (2014)

Objective: We sought to assess the cardiac protective effects after MI of (1) PC differentiated directly into cardiomyocytes (CM) and endothelial cells (EC) to the site of injury, or (2) paracrine factors released from PC. Methods: These concepts were evaluated by using iPSC-derived PC genetically modified to express the herpes simplex virus thymidine kinase (TK) under the control of cardiomyocyte (NCX1) or endothelial cell (VE-cadherin) specific promoters. PC expressing the TK permitted ablation at the first week or the third week by iv ganciclovir (GCV). If GCV applied at the first week, but not at the third week, altered cardiac function, we would conclude that myocardial contractile recovery depends on CM and EC-derived from iPSC. If the beneficial effects on cardiac function persisted after GCV was given at the third week, we would surmise that the PC effect was via by a paracrine action. MI created by ligation of LAD, the cell patch with PC was applied to the scarred myocardium. Rats were treated with GCV at 1 or 3 weeks to ablate implanted PC. Echocardiography, vessel density, and histological analysis were used to obtain endpoints for this study. Result: In vivo : The levels of IGF-1α and VEGF released from ischemic tissues were significant higher in the cell patch group. Heart function, infarction size, and vessel density were significantly improved after cell patch treatment. However, this beneficial effect on cardiac function was completely abolished in the group given GCV at week 1, but only partially abolished in the group given GCV at week 3 compared to the untreated cell patch group. Conclusions: Taken together, these data support our conclusion that iPSC-derived cardiovascular lineages (CM and EC) contribute directly to an improved cardiac performance and attenuated remodeling, and that paracrine factors also play a supporting role in the restoration of heart function after MI.
The Effect of Valsartan, Captopril, or Both on Atherosclerotic Events After Acute Myocardial Infarction
Authors: John McMurray, Scott Solomon, Karen Pieper, Shelby Reed, Jean Rouleau, Eric Velazquez, Harvey White, Jonathan Howlett, Karl Swedberg, Aldo Maggioni, Lars Køber, Frans Van de Werf, Rob Califf, Marc Pfeffer
Journal: Journal of the American College of Cardiology (2006)
Abstract P193: Relation to Blood Pressure of Total and Individual Components of Dietary Fiber and Sugar: The Intermap Study
Authors: Ghadeer S Aljuraiban, Linda M Oude Griep, Queenie Chan, Martha L Daviglus, Jeremiah Stamler, Linda Van Horn, Paul Elliott, Gary Frost
Journal: Circulation (2014)

Background: Epidemiological evidence is limited and inconclusive on the separate contributions of soluble, insoluble fiber and dietary sugars to blood pressure (BP). This population based study examines relations to systolic and diastolic BP (SBP/DBP) of total dietary fiber and sugar and their individual components. Methods: Cross-sectional data were analysed from the population-based INTERMAP study, including 2,195 participants ages 40 to 59 from the United States. During 4 visits, eight BP readings were recorded and dietary intake was assessed by four in-depth 24-hour dietary recalls. Intakes of fiber and sugars (g/1000 kcal) were averaged over 4 days. In successive models, BP regression coefficients per 2 SD higher intake were estimated using isocaloric, multivariable linear regression with adjustment for multiple possible confounders (non-dietary and dietary), including each of the other individual dietary fiber or sugars. Results: Average intake (SD; g/1000 kcal) of total fiber was 8.8(3.3); soluble fiber 2.8(1.0); insoluble fiber 5.3(2.2). Average intake (SD; %kcal) of total sugar was 26.7(7.9) and of sucrose, the largest component, 10.8 (5.1). Partial Pearson correlation coefficients were low between total fiber and total sugar ( r =0.02), and high between soluble and insoluble fiber ( r =0.80). Correlations between fructose and other individual sugars were high only for glucose ( r =0.93), low ( r &lt;0.15) for other sugars.Total dietary fiber intake higher by 7 g/1000 kcal was associated with SBP lower by 1.7 mm Hg (P=0.01) in an isocaloric model adjusted for lifestyle factors in addition to total sugar (%); this was attenuated with further adjustment for urinary potassium excretion. This association was accounted for by the observed inverse association of insoluble fiber with SBP (-2.0 mm Hg, P=0.04), additionally adjusted for soluble fiber. Inverse associations with SBP were found for dietary galactose (-1.5 mm Hg; P=0.04) and lactose (-2.1 mm Hg;P=0.0006). Intakes of total sugar, fructose, glucose, maltose, and sucrose were not associated with BP in isocaloric models adjusted for lifestyle factors and each of the other individual dietary sugars. Conclusions: Higher intakes of dietary fiber, especially insoluble fiber, may contribute to lower BP, possibly driven by potassium present in high fiber foods. Total sugar intake was not associated with blood pressure; however, intakes of galactose and lactose may favorably influence blood pressure.
878. Correction of Maternal Phenylketonuria Syndrome in the Pahenu2 Missense Mutant Mouse by r-AAV Mediated Gene Therapy
Authors: Philip J. Laipis, Catherine E. Charron, Jennifer E. Embury, O. P. Perera, Stacey L. Porvasnik, Carl R. Fields, Roberto T. Zori
Journal: Molecular Therapy (2004)
Quantitative CT measurements associated with response to coil-based LVR treatment
Authors: Youbing Yin, Konstantina Kontogianni, Maren Schuhmann, Philippe Raffy, Ralf Eberhardt, Daniela Gompelmann, Felix J.F. Herth
Journal: European Respiratory Journal (2014)

Background : Bronchoscopy-guided lung volume reduction (LVR) treatment with coils is emerging as a new procedure to treat patients with severe emphysema.   Purpose : To identify quantitative Computed Tomography (QCT) associated with positive treatment outcome.   Method : 34 patients received LVR treatment using PneumRx coils. Changes in FEV1, residual volume (RV) and 6-minute walk distance (6MWD) between the baseline and 3-month follow-up were used as indicators of treatment efficacy. Fissure integrity (FI), emphysema percentage (EP), heterogeneity score (HS), and low attenuation cluster (LAC) based measurements (LAC slope, hole size mean (HSM), hole size standard deviation (HSSD)) were calculated from baseline scans.   Results : HS and FI had weak or no correlation against all efficacy measures, which suggest that collateral ventilation and heterogeneity across the treated lung may not play important roles (Table 1). However, significant correlations with RV changes were observed for intra-lobar QCT measurements: EP (ρ=-0.491), LAC-HSM (ρ=-0.516), LAC-HSSD (ρ=-0.512). No significant correlation was observed for ΔFEV1 and Δ6MWD.   Conclusion : QCT measurements of emphysema within the treated lobe are associated with improvement in lung compliance consecutive to LVR coil treatment, which could lead to a more targeted CT-based approach to patient selection.
Systemic administration of attenuated Salmonella choleraesuis in combination with cisplatin for cancer therapy
Authors: Che-Hsin Lee, Chao-Liang Wu, Yun-Sheng Tai, Ai-Li Shiau
Journal: Molecular Therapy (2005)

Some anaerobic and facultative anaerobic bacteria have been employed as anticancer agents. Previously, we have demonstrated tumor-targeting and antitumor activities of attenuated Salmonella choleraesuis carrying antiangiogenic genes. Here we exploited S. choleraesuis as a single-agent therapy and as part of a combination therapy with low-dose cisplatin for syngeneic murine lung tumor and hepatoma. Systemically injected S. choleraesuis preferentially accumulated within tumors for at least 4 weeks and the bacteria accumulated preferentially in not only subcutaneous but also orthotopic tumors over livers and spleens at ratios ranging from 1000:1 to 100,000:1. S. choleraesuis was capable of delaying tumor growth and enhancing survival in both subcutaneous tumor and experimental metastasis models. More strikingly, the combination of S. choleraesuis plus cisplatin acted additively to retard tumor growth and extensively prolong the survival time of the mice bearing hepatomas or lung tumors. Such combination treatment also increased infiltrating neutrophils and CD8+ T cells, as well as apoptotic cells, in the tumors, compared with S. choleraesuis or cisplatin treatment alone. These findings suggest that S. choleraesuis in combination with cisplatin, which exerts oncolytic effects and enhances antitumor immune responses, represents a promising strategy for the treatment of primary and metastatic tumors.
Activated Platelets Release Two Types of Membrane Vesicles: Microvesicles by Surface Shedding and Exosomes Derived From Exocytosis of Multivesicular Bodies and -Granules
Authors: Harry F.G. Heijnen, Anja E. Schiel, Rob Fijnheer, Hans J. Geuze, Jan J. Sixma
Journal: Blood (1999)
357. Selective Depletion of Kupffer Cells Leads to Enhanced Transgene Expression in Rat Liver Following Intraductal Infusion of Naked DNA and DNA Nanoparticles
Authors: Hui Dai, Xuan Jiang, Weiseng Lim, Xuesong Jiang, Yong Chen, Hai-Quan Mao, Kam W. Leong
Journal: Molecular Therapy (2004)
Abstract 104: Intra-arrest Mild Hypothermia Following Delayed CPR Did Not Improve Survival in Asphyxial Cardiac Arrest Model in Rats
Authors: Jie Liu, Meng Chen, Yue Wang, Fei Han
Journal: Circulation (2014)

Introduction: Ischemia/reperfusion injury induced cellular damage and organ dysfunction after prolonged cardiac arrest. Ischemia introduced a susceptibility to damage that may worsen by reperfusion...
The Development of Alcohol Strategies in England and Wales
Authors: Simon A Wallace, Jennifer Bennett, Brendan Ward
Journal: Journal of the Royal Society of Medicine (1993)

Alcohol has become a major public health problem in the UK. In order to coordinate the work of both statutory and non-statutory agencies more efficiently and effectively, a government circular HN(89)4 has emphasized the need for development of local multi-agency alcohol misuse prevention strategies. Despite expressed enthusiasm for alcohol strategies, information about their development, effectiveness and overall national progress is scarce and needs to be improved. This national survey reports the most recent and accurate information about the development of district and regional alcohol strategies in England and Wales. Although only 51 (27%) districts stated they had a strategy, it was encouraging to find 90 (47%) other districts that were in the process of, or planning to develop such a document. Of the 51 districts with a strategy, the following key findings were noted: (1) Forty-three (84%) districts stated that they had started to implement their strategy, but none claimed to have fully implemented it. (2) Thirty-six (71%) districts stated that their strategy had an action plan. (3) Thirty-four (67%) districts stated that their strategy had been officially endorsed by the district health authority. (4) Thirty-eight (76%) districts stated that they had identified an individual or group to monitor the strategies' implementation. The results of the survey could be of interest to the Department of Health, the Faculty of Public Health Medicine, the Health Education Authority and the regional alcohol coordinators.(ABSTRACT TRUNCATED AT 250 WORDS)
Skin Autografts and Homografts in Patients with the Lymphoma Mycosis Fungoides
Authors: W. E. Clendenning, E. J. Van Scott
Journal: Cancer Research (1965)

In a series of autografts done in 14 patients with mycosis fungoides (MF), normal skin could be transplanted without difficulty to either normal recipient sites or sites involved with lymphoma. In contrast, transplantation of skin involved with lymphoma was infrequently successful. Mycosis fungoides tumor tissue was never transferred successfully, and in no instance was transfer of disease accomplished by transplantation. Possible reasons for these findings are presented.

Homografts were done in 18 patients with mycosis fungoides. The initial take pattern was the same as in the autograft series. Sixteen of the 18 patients rejected normal skin homografts within a 23-day period. The 2 patients retaining grafts for longer periods were in terminal stages of their illness. Thus, no depression of this parameter of delayed hypersensitivity capacity was identified with this lymphoma.
Third Millennium Challenge: Hepatitis C
Authors: M J Friedrich
Journal: JAMA (1999)

CHICAGO—With as many as 4 million people in the United States and 200 million people worldwide estimated to harbor the hepatitis C virus (HCV), chronic HCV infection poses a serious threat to public health in the next century. Hepatitis C virus has a high chronicity rate and can persist for years in the body, slowly destroying the liver. But because infected individuals are typically asymptomatic for years—and even decades—after becoming infected, many are unaware they have contracted the virus. As time passes, however, the disease will be diagnosed in more people who were infected in the 1970s and 1980s, many of whom will have sustained irreparable liver damage. Hepatitis C, a common infection that can lead to chronic liver disease, cirrhosis, and hepatocellular carcinoma, is the leading cause of liver transplantation in the United States. The natural history of the disease is not well understood, and it is unclear whether all who are infected will develop progressive disease. Nevertheless, as the number of patients with HCV-associated liver disease grows, it is essential that researchers improve the ability to treat the infection. Numerous obstacles complicate the study of this enigmatic virus. But in spite of difficulties, progress is being made in unraveling its genetics and molecular biology, improving methods of prognostication, and developing better treatment options.
Abstract 3583: Reducing GC-bias and improving coverage distribution in Illumina sequencing using the Kapa Biosystems library construction method
Authors: Aaron R. Thorner, Ashwini Sunkavalli, Ling Lin, Robert T. Jones, Laura Schubert, Matthew D. Ducar, Ravali Adusumilli, Deniz Nesli Dolcen, Liuda Ziaugra, Jack Lepine, Laura E. MacConaill, William C. Hahn, Matthew Meyerson, Paul Van Hummelen
Journal: Cancer Research (2014)

Abstract Next-generation sequencing (NGS) is increasingly used in the laboratory and clinic to identify genomic factors contributing to tumorigenesis, such as somatic mutations, DNA insertions and deletions, transcriptome and epigenetic changes, and chromosomal abnormalities. Because tumor specimen tissues are often quite limited or are from rare and precious samples, it is necessary to prepare sequencing libraries from minimal amounts of DNA. Consequently, limited DNA input necessitates amplification during NGS library preparation. Therefore, it is of great importance to amplify the library in an efficient and uniform manner to achieve reproducible amplification of the library fragments and limit GC content bias. Variable GC-bias among libraries is of particular importance for copy number variant (CNV) detection based on sequence coverage. Here, we compare the TruSeq DNA Sample Preparation Kit (Illumina Inc., San Diego, CA) and the KAPA Library Preparation Kit (Kapa Biosystems, Wilmington, MA) to determine which technique achieves optimal library coverage. The major difference between the methods is the DNA polymerase used for library enrichment. The Kapa HiFi polymerase was engineered to have higher fidelity and increased DNA affinity relative to the Herculase II Fusion DNA Polymerase (Agilent Technologies, Inc., Santa Clara, CA) that we used for library enrichment with the TruSeq kit. Thus, the Kapa HiFi polymerase should more efficiently amplify targets across a larger GC content range and improve sequence coverage uniformity. Relative to TruSeq-prepared libraries, the Kapa-prepared libraries had a larger mean insert size, more uniform coverage distribution, and better coverage of GC-rich regions of the genome. This was observed for DNA extracted from blood, cell lines, and formalin-fixed paraffin embedded (FFPE) tumor samples. More experiments are underway to determine the effect of the improved recovery of high-GC content DNA fragments on CNV detection. Citation Format: Aaron R. Thorner, Ashwini Sunkavalli, Ling Lin, Robert T. Jones, Laura Schubert, Matthew D. Ducar, Ravali Adusumilli, Deniz Nesli Dolcen, Liuda Ziaugra, Jack Lepine, Laura E. MacConaill, William C. Hahn, Matthew Meyerson, Paul Van Hummelen. Reducing GC-bias and improving coverage distribution in Illumina sequencing using the Kapa Biosystems library construction method. [abstract]. In: Proceedings of the 105th Annual Meeting of the American Association for Cancer Research; 2014 Apr 5-9; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2014;74(19 Suppl):Abstract nr 3583. doi:10.1158/1538-7445.AM2014-3583
Strongyloidiasis, angio-oedema and natural killer cell lymphocytosis: reply from authors
Authors: E.L. Speight, B. Myers, J.M. Davies
Journal: British Journal of Dermatology (2000)

Journal Article Strongyloidiasis, angio‐oedema and natural killer cell lymphocytosis: reply from authors Get access E.L. Speight, E.L. Speight Department of Dermatology, Dryburn Hospital, Durham DH1 5TW, U.K. Search for other works by this author on: Oxford Academic Google Scholar B. Myers, B. Myers Department of Haematology, University Hospital, Queen’s Medical Centre, Nottingham NG7 2UH, U.K. Search for other works by this author on: Oxford Academic Google Scholar J.M. Davies J.M. Davies Department of Haematology, University Hospital, Queen’s Medical Centre, Nottingham NG7 2UH, U.K. Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 142, Issue 5, 1 May 2000, Page 1066, https://doi.org/10.1046/j.1365-2133.2000.03513.x Published: 01 May 2000