tbuckley/cabot-search huggingface dataset:
Depression and Pesticide Exposures among Private Pesticide Applicators Enrolled in the Agricultural Health Study
Authors: Cheryl L. Beseler, Lorann Stallones, Jane A. Hoppin, Michael C.R. Alavanja, Aaron Blair, Thomas Keefe, Freya Kamel
Journal: Environmental Health Perspectives (2008)

BackgroundWe evaluated the relationship between diagnosed depression and pesticide exposure using information from private pesticide applicators enrolled in the Agricultural Health Study between 1993 and 1997 in Iowa and North Carolina.MethodsThere were 534 cases who self-reported a physician-diagnosed depression and 17,051 controls who reported never having been diagnosed with depression and did not feel depressed more than once a week in the past year. Lifetime pesticide exposure was categorized in three mutually exclusive groups: low (< 226 days, the reference group), intermediate (226–752 days), and high (> 752 days). Two additional measures represented acute high-intensity pesticide exposures: an unusually high pesticide exposure event (HPEE) and physician-diagnosed pesticide poisoning. Logistic regression analyses were performed relating pesticide exposure to depression.ResultsAfter adjusting for state, age, education, marital status, doctor visits, alcohol use, smoking, solvent exposure, not currently having crops or animals, and ever working a job off the farm, pesticide poisoning was more strongly associated with depression [odds ratio (OR) = 2.57; 95% confidence interval (CI), 1.74–3.79] than intermediate (OR = 1.07; 95% CI, 0.87–1.31) or high (OR = 1.11; 95% CI, 0.87–1.42) cumulative exposure or an HPEE (OR = 1.65; 95% CI, 1.33–2.05). In analysis of a subgroup without a history of acute poisoning, high cumulative exposure was significantly associated with depression (OR = 1.54; 95% CI, 1.16–2.04).ConclusionThese findings suggest that both acute high-intensity and cumulative pesticide exposure may contribute to depression in pesticide applicators. Our study is unique in reporting that depression is also associated with chronic pesticide exposure in the absence of a physician-diagnosed poisoning.
ACNE ROSACEA TREATED BY INTRADERMAL INJECTIONS OF FORMALDEHYDE.
Authors: J. T. McSHANE
Journal: JAMA (1897)

The patient, an unmarried lady 30 years of age, has suffered from acne rosacea, with pustulation and papulation for about ten years. The entire face was involved with redness, most marked over cheeks and nose, and always worse during menstruation. The patient is well nourished but has suffered from nervousness and despondency, perhaps due largely to her necessary isolation from society on account of the bad appearance of her face. She has been under the professional care of several first-class physicians and all the usual means of treatment have been resorted to, but without avail. I decided with the consent of my patient to use intradermal injections of formaldehyde in the strength of 1 drop of the 40 per cent. solution to 100 drops of water. These injections are attended with a stinging pain which the patient compares to the sting of a bee. One-half to one minim was injected
Mitochondrial proteins that regulate apoptosis and necrosis are induced in mouse fatty liver
Authors: Asif Rashid, Tzyy-Choou Wu, Chao-Cheng Huang, Chien-Hung Chen, Hui Zhi Lin, Shi Qi Yang, Fung Ye Lee, Anna Mae Diehl
Journal: Hepatology (1999)

Fatty liver is common in nonalcoholic, obese individuals and in lean people who consume alcohol chronically. Although fatty liver is typically benign, a subset of individuals with steatosis develop steatohepatitis and eventually cirrhosis. The disparate outcomes of fatty liver suggest that it reflects a generally beneficial, adaptive response to obesity or alcohol-related stress, but may also increase hepatocyte vulnerability to other challenges. Thus, both protective factors (e.g., Bcl-2 and Bcl-xL) and factors that promote hepatocyte death by apoptosis (e.g., Bax) or necrosis (e.g., UCP2) may be increased in fatty livers. To evaluate this possibility, hepatocyte apoptosis, necrosis, and the expression of factors that regulate cellular viability were assessed in two models of fatty liver (i.e., genetically obese [ob/ob] mice and ethanol [EtOH]-fed lean mice). Findings in mice with fatty livers were compared with lean, control mice that did not have hepatic steatosis. Immunohistochemistry showed striking induction of hepatocyte proteins that promote (e.g., Bax) and inhibit (e.g., Bcl-2 and Bcl-xL) apoptosis in both groups with fatty liver. Both models of fatty liver also increased hepatic transcripts for UCP2, a mitochondrial uncoupling protein, and the protein itself was induced in ob/ob hepatocytes. Despite the up-regulation of factors that threaten cell viability, hepatocyte death was not increased in either ob/ob or EtOH-fed mice, confirming that the liver's protective responses were sufficient under the conditions studied. However, if UCP2 induction reduces the efficiency of adenosine triphosphate (ATP) synthesis, this initially harmless response might enhance the vulnerability of hepatocytes to necrosis
Hemorrhagic Fever with Renal Syndrome and TammHorsfall Protein
Authors: P. Fievet, M. Boudjelal, R. Demontis, P. Veyssier, P. Y. Lallement, N. Bove, P. Ronco
Journal: Annals of Internal Medicine (1989)

Letters and Corrections15 February 1989Hemorrhagic Fever with Renal Syndrome and TammHorsfall ProteinP. Fievet, MD, M. Boudjelal, MD, R. Demontis, MD, P. Veyssier, MD, P. Y. Lallement, MD, N. Bove, MD, P. Ronco, MDP. Fievet, MDSearch for more papers by this author, M. Boudjelal, MDSearch for more papers by this author, R. Demontis, MDSearch for more papers by this author, P. Veyssier, MDSearch for more papers by this author, P. Y. Lallement, MDSearch for more papers by this author, N. Bove, MDSearch for more papers by this author, P. Ronco, MDSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-110-4-325_1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: Hemorrhagic fever with renal syndrome, which was recognized in France in 1982, is related to Puumala virus (1). The main histologic disorders of the kidney are medullar diffuse edema with interstitial hyperemia and hemorrhage, vacuolization and swelling of tubular epithelial cells, and the presence of cell casts (2). The intensity of these lesions varies, and the mechanism of renal insufficiency is still incompletely understood. In other diseases, such as multiple myeloma with renal failure, deposits of Tamm-Horsfall protein are present in the urinary spaces of glomeruli (3). Tamm-Horsfall protein is produced by epithelial cells of the thick...References1. MeryDardChamouar JSJ. Muroïd virus nephropathies. Lancet. 1983;2:845-6. CrossrefMedlineGoogle Scholar2. Ladhevirta J. Nephropathia epidemica in Finland: a clinical, histological and eidemiological study. Ann Clin Res. 1971;(suppl 8):1-154. MedlineGoogle Scholar3. RotaMougenotBaudoin SBB. Multiple myeloma and severe renal failure: a clinicopathologic study of outcome and prognosis in 34 patients. Medicine. 1987;66:127-39. CrossrefGoogle Scholar4. BrunisholzGeniteau-LegendreRonco MMP. Characterization of monoclonal antibodies specific for human Tamm-Horsfall protein. Kidney Int. 1986;29:971-6. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByUrinary Neutrophil Gelatinase-Associated Lipocalin (NGAL) and proteinuria predict severity of acute kidney injury in Puumala virus infectionClinical Aspects of Nephropathia Epidemica (Puumala Virus Infection) in Europe: A ReviewPathogenetic and Clinical Aspects of the Renal Involvement in Hemorrhagic Fever with Renal Syndrome 15 February 1989Volume 110, Issue 4Page: 325-325KeywordsEdemaEpithelial cellsHemorrhageHemorrhagic feversInflammationKidneysLesionsMultiple myelomaProteinsRenal failure Issue Published: 15 February 1989 PDF DownloadLoading ...
Abstract LB-315: Suppression of tumor invasion and metastasis by inhibition of c-MET and VEGF signaling together
Authors: Barbara Sennino, Toshina Ishiguro-Oonuma, Casey W. Williamson, Ying Wei, Harold A. Chapman, James G. Christensen, Dana T. Aftab, Donald M. McDonald
Journal: Cancer Research (2012)

Abstract Treatment with inhibitors that block vascular endothelial growth factor (VEGF) signaling can make tumors more aggressive in preclinical models. The mechanism underlying this form of resistance is not fully understood, but vascular pruning, intratumoral hypoxia, and increased expression of c-MET, the tyrosine kinase receptor for hepatocyte growth factor (HGF), could be contributing factors. We found that treatment of pancreatic neuroendocrine tumors in RIP-Tag2 mice with a neutralizing anti-VEGF antibody or with sunitinib, a receptor tyrosine kinase inhibitor that blocks VEGFR and related receptors, reduced tumor burden and vascularity but increased intratumoral hypoxia, HIF-1alpha, and expression and activation of c-MET. Invasion into the exocrine pancreas and metastasis to the liver also increased. Importantly, administration of either of two c-MET inhibitors, PF-04217903 or crizotinib (PF-02341066), together with anti-VEGF therapy reduced tumor growth and vascularity and also significantly decreased local invasion and liver metastasis. Similar benefits were found after treatment with cabozantinib (XL184), a multitargeted tyrosine kinase inhibitor that simultaneously blocks c-MET and VEGF receptors. Together, these results indicate that inhibition of VEGF signaling can promote vascular pruning, intratumoral hypoxia, HIF-1alpha accumulation, and activation of c-MET. Concurrent inhibition of c-MET and VEGF signaling not only can slow tumor growth but also can reduce invasion and metastasis. Inhibition of c-MET and VEGF signaling pathways together combines the favorable tumor growth-slowing effects of inhibiting angiogenesis with suppression of invasion and metastasis, despite the intratumoral hypoxia due to vascular pruning. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 103rd Annual Meeting of the American Association for Cancer Research; 2012 Mar 31-Apr 4; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2012;72(8 Suppl):Abstract nr LB-315. doi:1538-7445.AM2012-LB-315
NIH Expects Conflict-of-Interest Rule Revisions to Take at Least 6 Months
Authors: Charles Marwick
Journal: JAMA (1990)

THE NATIONAL Institutes of Health (NIH), Bethesda, Md, is planning at least one meeting with scientists and administrators from industrial, academic, and independent research institutions before attempting to redraft conflict-of-interest rules (<i>JAMA</i>. 1988; 260:2011-2012). The revision itself is expected to take at least 6 months. It was about 6 months ago that NIH, in association with the Alcohol, Drug Abuse, and Mental Health Administration, published a proposed set of guidelines for institutions and individuals regarding conflict of interest. Among those proposed guidelines is a requirement that anyone doing federally funded research must make full disclosure of all financial interests and outside (of the research involved) professional activities. The proposed disclosure provision extends to spouses and others in the general category of dependents. Another proposed requirement would prohibit anyone involved in a research project from owning shares or having other financial interests in any company that could be affected by the
The distribution and characteristics of transplant coronary disease in a prospective morphometric analysis of intracoronary ultrasound
Authors: Jay A. Johnson, Jon A. Kobashigawa, Lawrence Yeatman, Jeffrey G. Carr, Kevin D. Trosian, Alejandro Sabad, Lianne S. Werner, Davis Drinkwater, Hillel Laks
Journal: Journal of the American College of Cardiology (1996)
A cool drink for an ardent fever
Authors: T. Dalrymple
Journal: BMJ (2008)

It is difficult not to write the history of medicine as the history of progress; but how is progress measured, and when exactly did it begin? Discoveries were often made a very long time before anyone benefited from them. Is progress an increase in knowledge, in curative power, or in both? When was the first life saved by the anatomy of Vesalius?

These questions came to my mind as I was reading Ibn al-Jazzar on fevers. Ibn al-Jazzar was an eminent physician of the 10th century who practised in north Africa and wrote a compendium of medicine, Provisions for the Traveller and Nourishment for the Sedentary , that was famous in its day and …
Listeria monocytogenes causing hospital-acquired enterocolitis and meningitis in newborn infants.
Authors: S Larsson, A Cederberg, S Ivarsson, L Svanberg, S Cronberg
Journal: BMJ (1978)

These findings emphasise the importance of daily close monitoring of peak and trough concentrations of aminoglycosides as well as concentrations before and after dialysis.A 24-hour Ion-call rapid assay service allowed us to make frequent changes in dosage and timing according to the results obtained.In our experience aminoglycosides are effective and safe in this group of patients, and treatment may thus be started before infection has been bacteriologically confirmed.Immunosuppression predisposes to candida infection after renal transplantation.We did not find more patients with the infection as a result of antibiotic treatment, and only two needed treatment with flucytosine.*More detailed information on each patient is available on request.
Tuberculosis in Correctional Institutions
Authors: Dixie E. Snider
Journal: JAMA (1989)

In this issue ofThe Journal, Braun et al<sup>1</sup>document the increasing problem of tuberculosis (TB) in the New York State Department of Correctional Services. Tuberculosis is not a new problem in correctional facilities in New York. A chest roentgenographic survey conducted among inmates of the New York State Department of Corrections from 1944 through 1948 found a prevalence of "clinically significant tuberculosis" of 1.2% among men and 0.7% among women. This prevalence was significantly higher than that in the general population, which was estimated to be about 0.3%.<sup>2</sup>In 1970, Abeles et al<sup>3</sup>reported the prevalence of "active tuberculosis" among newly admitted inmates in the New York City correctional system to be 0.2%. The problem of TB in correctional facilities has never been limited to New York.<sup>4-6</sup>In fact, a recent survey of 15 379 TB cases reported from 29 states during 1984 and 1985
Human Infection With Fungi, Actinomycetes and Algae
Authors: J. Walter Wilson
Journal: JAMA (1971)

This book is by far the largest of any volume on fungous disorders of man and it is at once evident, easily the most complete. Close scrutiny has failed to discover anything worth criticizing in the texts; wherever there are variations in opinions, all are given good exposure. The bibliography of each chapter is impressively complete and annotated; the indexing is superbly amplified; even the "authors quoted" are furnished with an additional alphabetical index. Each chapter is authored by a recognized expert in the respective diseases. Most of the authors are pathologists, with a few microbiologists. It is perhaps unfortunate that the title of the book does not indicate this bias, for it is this intensive and intimate interest in the gross and microscopic anatomy of human tissues infected with these microorganisms which furnishes the additional number of pages previously referred to. In many of the chapters the segments devoted
Frequency-dependent effects of verapamil on atrioventricular nodal conduction in man.
Authors: K A Ellenbogen, L D German, W G O'Callaghan, P G Colavita, A C Marchese, M R Gilbert, H C Strauss
Journal: Circulation (1985)

We sought to determine if verapamil induces frequency-dependent prolongation of atrioventricular nodal conduction in 10 consecutive patients studied in the electrophysiology laboratory. We used a maintenance infusion of verapamil designed to produce plasma concentrations of verapamil in the "therapeutic" range and that did not alter heart rate or blood pressure significantly. Frequency-dependent prolongation of atrioventricular nodal conduction (AH interval) was demonstrated in all 10 patients (p less than .001), and no change in HV conduction time with decreasing cycle length was noted in any patients while receiving verapamil. Two patterns of use-dependent response were seen. In four patients frequency-dependent prolongation of the delta(AH) interval [delta(AH) = AHverapamil - AHcontrol at a given cycle length] was seen with each decrement in pacing cycle length. In six patients frequency-dependent prolongation of the delta(AH) interval was not manifest until the fifth to eighth pacing cycle length tested. There was no association between the pattern observed and the initial heart rate or AH interval. After an abrupt change in pacing cycle length, the kinetics of delta (AH) interval prolongation were rapid; equilibrium was achieved by five to eight pulses in all patients. There was no correlation between the magnitude of prolongation of the AH interval noted at a particular cycle length and the concentration of verapamil during the maintenance infusion. These results indicate that verapamil causes use-dependent prolongation of atrioventricular nodal conduction in man.
DNA Sequences Similar to Those of Simian Virus 40 in Ependymomas and Choroid Plexus Tumors of Childhood
Authors: Daniel J. Bergsagel, Milton J. Finegold, Janet S. Butel, William J. Kupsky, Robert L. Garcea
Journal: New England Journal of Medicine (1992)

Ependymomas and papillomas of the choroid plexus occur in early childhood. The ubiquitous human polyomaviruses, BK virus and JC virus, have been associated with the induction of these neoplasms in animal models. A related monkey polyomavirus, simian virus 40 (SV40), is highly tumorigenic in rodents and also induces choroid plexus papillomas.
Jean Astruc Physician-Theologian
Authors: Renwick K. Caldwell
Journal: JAMA (1965)

<h3>To the Editor:—</h3> The editorial on Jean Astruc (<i>JAMA</i><b>192</b>:249 [April 19] 1965) focuses attention on an interesting and controversial historical character. The same man whose scholarship literally unlocked the key to the Scriptures was reportedly described by Voltaire as, "Miser, débauché, and possessed with the devil." Astruc's work followed that of many theologians and philosophers. Ibn Ezra, the Spanish-Jewish philosopher of the 12th century, hinted at contradictory passages in the Bible but the bigotry of his age prevented him from openly announcing his discoveries. Benedict Spinoza, excommunicated from the Jewish colony in Amsterdam in 1656, earned his living as a lens grinder and in 1670 published anonymously his<i>Tractatus Theologico-Politicus</i>. In the<i>Tractatus</i>Spinoza said that the Pentateuch was not the work of Moses but a natural book written by many men. The<i>Tractatus</i>created an immediate sensation, was promptly placed in the<i>Index Purgatorius</i>, and was the
Part 6: Electrical Therapies
Authors: Mark S. Link, Dianne L. Atkins, Rod S. Passman, Henry R. Halperin, Ricardo A. Samson, Roger D. White, Michael T. Cudnik, Marc D. Berg, Peter J. Kudenchuk, Richard E. Kerber
Journal: Circulation (2010)

The recommendations for electrical therapies described in this section are designed to improve survival from SCA and life-threatening arrhythmias. Whenever defibrillation is attempted, rescuers must coordinate high-quality CPR with defibrillation to minimize interruptions in chest compressions and to ensure immediate resumption of chest compressions after shock delivery. The high first-shock efficacy of newer biphasic defibrillators led to the recommendation of single shocks plus immediate CPR instead of 3-shock sequences that were recommended prior to 2005 to treat VF. Further data are needed to refine recommendations for energy levels for defibrillation and cardioversion using biphasic waveforms.
Diabetes care: whose responsibility?
Authors: P Home, S Walford
Journal: BMJ (1984)

option-indeed, Griffiths and Baboonian state that their results "argue strongly against any therapeutic benefit of advising termination of pregnancy in women with primary CMV infection early in pregnancy.",Yet the problem remains.If generally less damaging, congenital cytomegalo- virus infection is twice as common as congenital rubella, and the infected children who develop sequelae represent a considerable toll of individual and family distress.
Abraham Stone Freedberg
Authors: N. Stafford
Journal: BMJ (2010)

A Stone Freedberg was an American cardiologist whose pioneering research of stomach ulcers helped lay the foundation for the later identification of Helicobacter pylori. 

It was no doubt one of the sweetest moments of A Stone Freedberg’s long life when he opened up the Lancet issue of 4 June 1983 to find letters to the editor from Barry J Marshall and J Robin Warren. The two Australian researchers had identified bacteria, now known as Helicobacter pylori , among patients with stomach ulcers.

After reading the exciting news, Freedberg, at the time a 75 year old professor emeritus of cardiology at Harvard Medical School, typed a short letter, beginning: “Dear Dr Marshall: I was very pleased to see the letters from Dr Warren and you on the spiral bacteria in human stomachs. It’s over 40 years since I spent evenings and weekends cutting and staining tissues from stomach operations ….”

Indeed, Freedberg in 1939 had suspected that bacteria might be the cause of ulcers. After countless hours in the laboratory he co-authored a paper on the topic that was mostly ignored or ridiculed—medical experts at the time, and for decades to come, blamed ulcers mainly on stress. Freedberg discontinued his research, which remained mostly forgotten until cited in Marshall’s 1983 letter in …
The Care of the Patient
Authors: C. Sidney Burwell
Journal: New England Journal of Medicine (1956)

IT is a great pleasure to have the privilege of representing the physicians of Boston in making these brief remarks at the opening of this distinguished meeting. Boston has good traditions of medicine and likes to think that the standards of thought and practice have been high since its early days. In the course of my remarks I propose to discuss certain general objectives of medicine and some general policies or principles by which these objectives may be realized.This is a meeting of many doctors brought together by a common interest in medicine and in patients. It seems to . . .
CD271 IDENTIFIES HUMAN BONE MARROW STEM/PROGENITOR CELLS WITH A PROANGIOGENIC POTENTIAL AND CIRCULATING PROGENITOR CELLS MOBILIZED AFTER ACUTE MYOCARDIAL INFARCTION
Authors: Yoshitaka Iso, Jeffrey L. Spees, Takatoshi Sato, Shinji Koba, Youichi Kobayashi, Yoichi Takeyama, Hiroshi Suzuki
Journal: Journal of the American College of Cardiology (2010)