PHYSIOLOGIC BASIS FOR THE CLINICAL USE OF NORADRENALIN
Authors: U S VON EULER
Journal: Annals of Internal Medicine (1954)

Article1 October 1954PHYSIOLOGIC BASIS FOR THE CLINICAL USE OF NORADRENALINU. S. VON EULER, F.A.C.P. (Hon.), M.D.U. S. VON EULER, F.A.C.P. (Hon.), M.D.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-41-4-699 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe therapeutic use of noradrenalin was suggested by Biberfeld3 in Austria half a century ago because of its strong vasoconstrictor action and low toxicity, but his plea for the new drug evoked no response, and interest in noradrenalin as a drug was almost negligible before the late forties. Since that time the number of investigations dealing with its therapeutic applications has grown rapidly.Probably the most valuable and informative basis for the rational use of noradrenalin is its function as sympathetic nerve transmitter and suprarenal medullary hormone.5, 6, 16Incidentally, the old claim that the so-called natural adrenalin from suprarenal...Bibliography1. BarcroftSwan HHJ: Sympathetic control of human blood vessels, 1952, Williams and Wilkins Co., Baltimore. Google Scholar2. BearnBillingSherlock AGBS: The effect of adrenaline and noradrenaline on hepatic blood flow and splanchnic carbohydrate metabolism in man, J. Physiol. 115: 430, 1951. CrossrefMedlineGoogle Scholar3. Biberfeld J: Pharmakologische Eigenschaften eines synthetisch dargestellten Suprarenins und einiger seiner Derivate, Med. Klin. 2: 1177, 1906. Google Scholar4. Dunér H: Effect of insulin hypoglycemia of the secretion of adrenaline and noradrenaline from the suprarenal of cat, Acta physiol. 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Clin. and Lab. Invest. 3: 255, 1951. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: U. S. VON EULER, F.A.C.P. (Hon.), M.D.Affiliations: Stockholm, Sweden*Presented as the Lilly Lecture at the Thirty-fifth Annual Session of the American College of Physicians, Chicago, Illinois, April 7, 1954. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byVariability in response to norepinephrine in acute myocardial infarctionÜber den Einfluß der Lageänderung auf Herzfrequenz, Blutdruck und Katecholaminausscheidung im Harn bei Säuglingen, Kleinkindern und älteren KindernThe Use and Abuse of VasopressorsThe effects of diphtheritic toxaemia on blood vesselsREFERENCESTHERAPY IN COLLAPSE DUE TO MENINGOCOCCUS INFECTION*JAMES E. 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