A COMPARATIVE STUDY OF SOME RECENT SEROLOGIC TESTS FOR RHEUMATOID ARTHRITIS
Authors: W. M. Mikkelsen, I. F. Duff, L. Goodson, W. H. Coulter, C. Hertz
Journal: Annals of Internal Medicine (1960)

Article1 May 1960A COMPARATIVE STUDY OF SOME RECENT SEROLOGIC TESTS FOR RHEUMATOID ARTHRITISW. M. MIKKELSEN, M.D., I. F. DUFF, M.D., F.A.C.P., L. GOODSON, M.D., W. H. COULTER, B.S., C. HERTZ, B.S.W. M. MIKKELSEN, M.D.Search for more papers by this author, I. F. DUFF, M.D., F.A.C.P.Search for more papers by this author, L. GOODSON, M.D.Search for more papers by this author, W. H. COULTER, B.S.Search for more papers by this author, C. HERTZ, B.S.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-52-5-1051 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptIn 1931 Nicholls and Stainsby1reported that the serum of many patients with rheumatoid arthritis was capable of agglutinating certain strains of streptococci. Subsequently it has been demonstrated2that this is not a specific reaction with the streptococcus, but that, under suitable conditions, agglutination of a variety of indicator particles can be produced by rheumatoid sera. The so-called "rheumatoid factor" responsible for this agglutination phenomenon has been extensively studied in an attempt to gain better understanding of the basic pathogenesis of the disease. It has been shown to behave electrophoretically as a gamma globulin,3, 4to have the solubility characteristics...Bibliography1. NichollsStainsby EEWJ: Streptococcal agglutinins in chronic infectious arthritis, J. Clin. Investigation 10: 323-335, 1931. CrossrefMedlineGoogle Scholar2. Wallis AD: Rheumatoid arthritis. II. Nonspecific serologic reactions, Am. J. M. Sc. 212: 716-717, 1946. CrossrefMedlineGoogle Scholar3. Lamont-Havers RW: Nature of serum factors causing agglutination of sensitized sheep cells and group A hemolytic streptococci, Proc. Soc. Exper. Biol. and Med. 88: 35, 1955. CrossrefMedlineGoogle Scholar4. SvartzSchlossmann NK: Cold precipitable hemagglutinating factor in serum from patients with rheumatoid arthritis, Ann. Rheumat. Dis. 14: 191-194, 1955. CrossrefMedlineGoogle Scholar5. Ziff M: A hemagglutination test for rheumatoid arthritis with enhanced sensitivity using the euglobulin fraction, Bull. Rheumat. Dis. 5: 75-76, 1954. MedlineGoogle Scholar6. Svartz N: Macroglobulins in rheumatoid arthritis, Acta med. scandinav. 158: 163-165, 1957. CrossrefMedlineGoogle Scholar7. FranklinHolmanMuller-EberhardKunkel ECHRHJHG: An unusual protein component of high molecular weight in the serum of certain patients with rheumatoid arthritis, J. Exper. Med. 105: 425-438, 1957. CrossrefMedlineGoogle Scholar8. KunkelFranklinMuller-Eberhard HGECHJ: Studies on the isolation and characterization of the "rheumatoid factor," J. Clin. Investigation 38: 424-434, 1959. CrossrefMedlineGoogle Scholar9. EpsteinJohnsonRagan WAC: Observations on a precipitin reaction between serum of patients with rheumatoid arthritis and a preparation (Cohn fraction II) of human gamma globulin, Proc. Soc. Exper. Biol. and Med. 91: 235-237, 1956. CrossrefMedlineGoogle Scholar10. SvartzSchlossmann NK: The agglutinating factor for sensitized sheep erythrocytes in serum and joint fluid from rheumatoid arthritis patients, Ann. Rheumat. Dis. 9: 377-379, 1950. CrossrefMedlineGoogle Scholar11. SingerPlotz JMCM: The latex fixation test. I. Application to the serologic diagnosis of rheumatoid arthritis, Am. J. Med. 21: 888-892, 1956. CrossrefMedlineGoogle Scholar12. BozicevichBunimFreundWard JJJJSB: Bentonite flocculation test for rheumatoid arthritis, Proc. Soc. Exper. Biol. and Med. 97: 180-183, 1958. CrossrefMedlineGoogle Scholar13. RopesBennettCobbJacoxJessar MWGASRRA: 1958 Revision of diagnostic criteria for rheumatoid arthritis, Bull. Rheumat. Dis. 9: 175-176, 1958. MedlineGoogle Scholar14. Ball J: Sheep cell agglutination test for rheumatoid arthritis; a clinico-pathological study, Ann. Rheumat. Dis. 11: 97-111, 1952. CrossrefMedlineGoogle Scholar15. JacobsonKammererWolfEpsteinHeller ASWHJWVG: The hemagglutination test for rheumatoid arthritis. III. Clinical evaluation of the sheep erythrocyte agglutination (S.E.A.) test and the gamma globulin (FII) tests, Am. J. Med. 20: 490-499, 1956. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Ann Arbor, Michigan*Received for publication December 21, 1959.A revision of a paper presented before the Fortieth Annual Session of The American College of Physicians, Chicago, Illinois, April 21, 1959.From the Rackham Arthritis Research Unit and Department of Internal Medicine, University of Michigan Medical School, and the Veterans Administration Hospital, Ann Arbor, Michigan.†The Rackham Arthritis Research Unit is supported by a grant from the Horace H. Rackham School of Graduate Studies. These studies were supported in part by the Michigan Chapter, Arthritis and Rheumatism Foundation.‡Vacation Fellowship, National Institute of Arthritis and Metabolic Diseases, Graduate Training Grant in Rheumatic Diseases.Requests for reprints should be addressed to William M. Mikkelsen, M.D., Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, Michigan. 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DUFF, M.D., F.A.C.P.Acquired Inhibitor of Blood CoagulationMARTIN L. LEE, M.D., GIOVANNI RACCUGLIA, M.D.Clinical Observations on the Latex Fixation TestSerologische Reaktionen beim akuten und chronischen Gelenkrheumatismus und ihre klinische BedeutungSerologische Untersuchungen im Leichenserum 1 May 1960Volume 52, Issue 5Page: 1051-1058KeywordsArthritisGraduate medical educationHospital medicineLatexMetabolic disordersPsoriatic arthritisRheumatic feverSpondylitisStreptococcusUlcerative colitis ePublished: 1 December 2008 Issue Published: 1 May 1960 PDF downloadLoading ...