tbuckley/cabot-search huggingface dataset:
Effect of Electronic Health Records on Health Care Costs: Longitudinal Comparative Evidence From Community Practices
Authors: Julia Adler-Milstein, Claudia Salzberg, Calvin Franz, E. John Orav, Joseph P. Newhouse, David W. Bates
Journal: Annals of Internal Medicine (2013)

The United States is aiming to achieve nationwide adoption of electronic health records (EHRs) but lacks robust empirical evidence to anticipate the effect on health care costs.To assess short-term cost savings from community-wide adoption of ambulatory EHRs.Longitudinal trial with parallel control group.Natural experiment in which 806 ambulatory clinicians across 3 Massachusetts communities adopted subsidized EHRs. Six matched control communities applied but were not selected to participate.47,979 intervention patients and 130,603 control patients.Monthly standardized health care costs from commercial claims data from January 2005 to June 2009, including total cost, inpatient cost, and ambulatory cost and its subtypes (pharmacy, laboratory, and radiology). Projected savings per member per month (PMPM), excluding EHR adoption costs.Ambulatory EHR adoption did not impact total cost (pre- to postimplementation difference in monthly trend change, -0.30 percentage point; P = 0.135), but the results favored savings (95% CI, $21.95 PMPM in savings to $1.53 PMPM in higher costs). It slowed ambulatory cost growth (difference in monthly trend change, -0.35 percentage point; P = 0.012); projected ambulatory savings were $4.69 PMPM (CI, $8.45 to $1.09 PMPM) (3.10% of total PMPM cost). Ambulatory radiology costs decreased (difference in monthly trend change, -1.61 percentage points; P < 0.001), with projected savings of $1.61 PMPM (1.07% of total PMPM cost).Intervention communities were not randomly selected and received implementation support, suggesting that results may represent a best-case scenario. Confounding is possible.Using commercially available EHRs in community practices seems to modestly slow ambulatory cost growth. Broader changes in the organization and payment of care may prompt clinicians to use EHRs in ways that result in more substantial savings.
Abstract 2021: ONO-WG-307, a novel, potent and selective inhibitor of Bruton's tyrosine kinase (Btk), results in sustained inhibition of the ERK, AKT and PKD signaling pathways
Authors: Tomoko Yasuhiro, Toshio Yoshizawa, Henrik Daub, Christoph Weber, Masami Narita, Kazuhito Kawabata
Journal: Cancer Research (2012)

Abstract Purpose: Btk is a key regulator of B cell receptors (BCR) which play a central role in signal transduction pathways regulating survival, activation, proliferation, and differentiation of B-lineage lymphoid cells. BCR signaling is implicated in the survival of malignant B cells and recent studies indicate that targeting Btk may be effective in the treatment of B-cell lymphoma. Response between cell survival and BCR signaling is implicated in different types of B-cell lymphoma. Therefore, we evaluated the inhibitory effect of ONO-WG-307 on Btk-dependent signal transduction by large-scale and quantitative phosphoproteome analysis to a depth of more than 10,000 phosphorylation sites. Methods: Two tumor cell lines (sensitive and non-sensitive) were treated with ONO-WG-307. After 72h, cell viability was determined by the CellTiter-Glo Luminescent Cell Viability Assay. P-Btk was used as a marker for Btk activity determined by Western blot and Flow Cytometry. Quantitative phosphoproteomics were enabled by differential SILAC labeling of lymphoma cells. After 1 hr incubation with ONO-WG-307, the total cellular proteins were digested and phosphopeptides were enriched by a combination of strong cation exchange and immobilized metal affinity chromatography. Site-specific phosphorylations were identified and by LC-MS analysis on a LTQ-Orbitrap-Velos mass spectrometer followed by bioinformatic processing. Results: Btk is potently and selectively inhibited by ONO-WG-307 in an in vitro Btk kinase assay, with an IC50 in the subnanomolar range whereas IC50 values for other tyrosine kinases (Lck, Lyn and Fyn) were above 1 µM. The concentration required for growth inhibition for the sensitive cells was 3.59 nmol/L (IC50), whereas considerably higher concentrations were required to suppress growth of non-sensitive cells. Surprisingly, inhibition of cellular Btk and ERK phosphorylation by ONO-WG-307 levels of P-Btk and P-ERK were similar in both sensitive and non-sensitive cells. However, our quantitative phosphoproteome studies revealed selective suppression of Akt-mediated signaling and cellular protein kinase D activity in sensitive compared to non-sensitive cells.Conclusion: These results suggest that the selective ONO-WG-307 inhibition of “responder” cell growth might be due to a critical role of Btk-mediated signaling through Akt and protein kinase D. These data shed new light on the cellular mode-of-action of Btk inhibition and support the potential clinical utility of ONO-WG-307 in B cell malignancies. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 103rd Annual Meeting of the American Association for Cancer Research; 2012 Mar 31-Apr 4; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2012;72(8 Suppl):Abstract nr 2021. doi:1538-7445.AM2012-2021
The Impact of Frequent and Unrecognized Hypoglycemia on Mortality in the ACCORD Study
Authors: Elizabeth R. Seaquist, Michael E. Miller, Denise E. Bonds, Mark Feinglos, David C. Goff, Kevin Peterson, Peter Senior
Journal: Diabetes Care (2011)

OBJECTIVE The aim of this study was to examine the relationship between frequent and unrecognized hypoglycemia and mortality in the Action to Control Cardiovascular Risk in Diabetes (ACCORD) study cohort. RESEARCH DESIGN AND METHODS A total of 10,096 ACCORD study participants with follow-up for both hypoglycemia and mortality were included. Hazard ratios (95% CIs) relating the risk of death to the updated annualized number of hypoglycemic episodes and the updated annualized number of intervals with unrecognized hypoglycemia were obtained using Cox proportional hazards regression models, allowing for these hypoglycemia variables as time-dependent covariates and controlling for the baseline covariates. RESULTS Participants in the intensive group reported a mean of 1.06 hypoglycemic episodes (self-monitored blood glucose &amp;lt;70 mg/dL or &amp;lt;3.9 mmol/L) in the 7 days preceding their regular 4-month visit, whereas participants in the standard group reported an average of 0.29 episodes. Unrecognized hypoglycemia was reported, on average, at 5.8% of the intensive group 4-month visits and 2.6% of the standard group visits. Hazard ratios for mortality in models including frequency of hypoglycemic episodes were 0.93 (95% CI 0.9–0.97; P &amp;lt; 0.001) for participants in the intensive group and 0.98 (0.91–1.06; P = 0.615) for participants in the standard group. The hazard ratios for mortality in models, including unrecognized hypoglycemia, were not statistically significant for either group. CONCLUSIONS Recognized and unrecognized hypoglycemia was more common in the intensive group than in the standard group. In the intensive group of the ACCORD study, a small but statistically significant inverse relationship of uncertain clinical importance was identified between the number of hypoglycemic episodes and the risk of death among participants.
Prevention of Heat Illness in Football Players
Authors: Robert J. Murphy
Journal: JAMA (1965)

Football practice in high schools and colleges in the United States begins at any time from the middle of August to early September and is performed with a full uniform on some of the hottest days of the summer. During the past decade, a significant number of deaths from heat stroke have occurred in athletics.<sup>1,2</sup>It is the purpose of this paper to attempt to provide a simple and inexpensive clinical guide to help team physicians and coaches recognize when conditions exist on the field which could predispose persons to problems of excessive heat. The amount of weight loss during a practice session is one excellent index of the amount of work performed in the environmental conditions which exist. Weight loss is primarily a result of work done, but the environmental temperature and humidity play a major role. The problem imposed by rising humidity (which is a function of
Impaired O_2 Delivery in Cyanate-Treated Animals.
Authors: Anthony Melaragno
Journal: Annals of Internal Medicine (1973)

Meeting Abstracts1 May 1973Impaired O2 Delivery in Cyanate-Treated Animals.Anthony Melaragno, B.S., Patrick W. Flanigan, M.D., Philip A. Bromberg, M.D., F.A.C.P., Stanley P. Balcerzak, M.D., F.A.C.P.Anthony Melaragno, B.S.Search for more papers by this author, Patrick W. Flanigan, M.D.Search for more papers by this author, Philip A. Bromberg, M.D., F.A.C.P.Search for more papers by this author, Stanley P. Balcerzak, M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-78-5-823_2 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptCyanate therapy of sickle-cell disease is currently under investigation. Since cyanate-treated erythrocytes have increased oxygen affinity, we studied the effect of chronic cyanate administration on tissue oxygen delivery in rats. Sodium cyanate (CNO) was administered for 8 weeks to two groups of rats. Thirty received 625 mg/kg body weight-week orally, and 30 received 250 mg/kg body weight-week intraperitoneally. Control animals received equivalent amounts of NaCl. Animals were killed at 2, 4, and 8 weeks, and blood oxygen affinity (P50), erythrocyte 2, 3-diphosphoglycerate (DPG), hematocrit, and erythrocyte mass were measured. Tissue oxygen delivery was assessed by skin bubble oxygen tension (SBpO2).... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Columbus, Ohio PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byOxygen transport and delivery in rabbits treated with cyanateStudies on the Mechanism of Cyanate Inhibition of Reticulocyte Protein Synthesis 1 May 1973Volume 78, Issue 5Page: 823-823KeywordsBloodHematocritOxygenSodiumSodium chloride ePublished: 1 December 2008 Issue Published: 1 May 1973 PDF downloadLoading ...
The Variable Bone Scan Appearances of Nonosteogenic Fibroma of Bone
Authors: N DAVID GREYSON, SUSAN PANG
Journal: Clinical Nuclear Medicine (1981)

Ten radiographically diagnosed fibrous defects of bone were assessed by three-phase bone scanning. Normal scans are obtained when the lesion is quiescent or has fully healed. Mild hyperemia and moderate bone uptake is present during the healing phase and is not significant. More intense hyperemia and a markedly positive bone scan suggest that a more active process, such as fracture or tumor, may be present.
S100P Promotes Pancreatic Cancer Growth, Survival, and Invasion
Authors: Thiruvengadam Arumugam, Diane M. Simeone, Kenneth Van Golen, Craig D. Logsdon
Journal: Clinical Cancer Research (2005)

Abstract Purpose: In the current study, we examined the functional significance and mechanism of action of S100P in pancreatic cancer cells. Experimental Design: S100P levels were increased in Panc-1 cells, which do not express S100P, by transfection with an S100P cDNA and S100P levels were reduced in BxPC3 cells, which express high levels of S100P, by small interfering RNA gene silencing. Effects of these manipulations on cell proliferation, resistance to apoptotic insults, cell migration, and invasion were estimated in vitro using standard assays. The influences of S100P on tumor growth in vivo were studied using xenograft mouse models. To identify the mechanisms involved in these responses, coimmunoprecipitation studies were conducted with S100P with receptor for advanced glycation end products (RAGE) and the effects of inhibiting RAGE using an antagonistic peptide were analyzed. Results: S100P levels correlated with the rates of cell proliferation, survival, migration, and invasion in both cell models in vitro. In vivo, increased S100P levels increased the growth of tumors in mice with s.c.-implanted Panc-1 cells and decreased S100P levels decreased tumor growth after orthotopic implantation of BxPC-3 cells. A direct interaction between S100P and RAGE was indicated by coimmunoprecipitation of these molecules from pancreatic cancer cells. A RAGE antagonist peptide inhibited this interaction and also inhibited the biological effects of S100P on these cells in vitro. Conclusions: These data suggest that S100P plays a major role in the aggressiveness of pancreatic cancer that is likely mediated by its ability to activate RAGE. Thus, interference with S100P may provide a novel approach for treatment of pancreatic cancer.
Use of longitudinal analysis of peripheral blood counts to validate historical reconstructions of benzene exposure.
Authors: H M Kipen, R P Cody, B D Goldstein
Journal: Environmental Health Perspectives (1989)

We studied over 17,000 peripheral blood counts, accumulated during hematologic surveillance from 1940 through 1975, from a cohort of 459 benzene-exposed workers. Linear regressions demonstrated significant decreases in white and red cell counts, as well as hemoglobin, for workers exposed during the 1940s, without persistent trends over the ensuing 25 years. Strongly positive correlations were observed between these blood count fluctuations and fluctuations in retrospective estimates of benzene exposures for these workers in the earlier period of surveillance (mean estimated exposure 1940 to 1948, 75 ppm), but not for later years, (mean estimated exposure 1948 to 1975, 15 to 20 ppm). These data suggest substantial limitations of hematologic examination of populations to detect abnormalities in populations currently exposed to benzene. The analysis also demonstrates a novel approach to the biological validation of exposure estimates based upon limited industrial hygiene and historical record data. The application of biologic monitoring data may be useful for assisting decisions in reconstruction of a previous exposure.
PURULENT OTITIS—ITS TREATMENT AND PREVENTION BY THE FAMILY PHYSICIAN.
Authors: H. GRADLE
Journal: JAMA (1900)

The scope of the present paper is defined exactly by its title. It is to present to the practitioner the teaching of modern otology regarding a very important disease, for acute purulent inflammation of the middle ear is so common that the majority of cases, at least among children, are seen by the general practitioner, and not by the specialist. Frequent experience has shown me that the form of treatment which progressive otologists have recognized as the best and safest has not yet been adopted by all general practitioners. Yet it is so much simpler than the less efficient methods so often employed or advised by physicians. It is but the application of ordinary surgical principles to purulent inflammation localized in the ear. Just as in the preantiseptic days, wounds did heal after a fashion, so in incorrectly treated cases purulent otitis will often heal, but delays and unfortunate accidents
Persistent Specific Bronchial Reactivity to Occupational Agents in Workers with Normal Nonspecific Bronchial Reactivity
Authors: CATHERINE LEMIÈRE, ANDRÉ CARTIER, JEAN-LUC MALO, SAMUEL B. LEHRER
Journal: American Journal of Respiratory and Critical Care Medicine (2000)

Specific bronchial reactivity (SBR) to common inhalants is related to the degree of nonspecific bronchial reactivity (NSBR) and to specific allergen sensitivity. We investigated 16 workers with normal NSBR who had been previously diagnosed with occupational asthma caused by high-molecular-weight agents. The agents were flour in seven workers, psyllium in five, and guar gum in four. The subjects had been removed from exposure to these agents for a mean of 5.7 ( ± 4.0 SD) yr, no longer showed evidence of persisting asthma, and had a normal lung function. In the present study, the workers were reexposed to the sensitizing agent by specific inhalation challenges, in the same way they were as at the time of the diagnosis, to assess their current SBR to the sensitizer. SBR was estimated as the duration of exposure that induced a 20% decrease in FEV1. Eleven of the 16 subjects had an asthmatic reaction at the time of the study; the duration of exposure necessary to induce the asthmatic reaction was the same as that needed at the time of diagnosis (3.55 ± 0.5 min and 4.2 ± 0.7 min, respectively, p = 0.8). The decrease in specific IgE levels between the two events was much greater in the subjects who failed to react to the second challenge test (from 24.2 ± 37.5% to 3.0 ± 16.9% binding) than in those who reacted on both occasions (from 31.2 ± 27.0% to 21.6 ± 36.7% binding); however, in both groups the change was significant (p = 0.05 and 0.04, respectively). We conclude that SBR to high-molecular-weight agents persists in most cases despite a normalization of NSBR, and that this persistence is associated with a persistence of specific immunization to the agent.
Adult hematopoietic stem cells provide functional hemangioblast activity during retinal neovascularization
Authors: Maria B. Grant, W. Stratford May, Sergio Caballero, Gary A. J. Brown, Steven M. Guthrie, Robert N. Mames, Barry J. Byrne, Timothy Vaught, Polyxenie E. Spoerri, Ammon B. Peck, Edward W. Scott
Journal: Nature Medicine (2002)
Effects of Intravenous Atrial Natriuretic Peptide on Cardiac Sympathetic Nerve Activity and Left Ventricular Remodeling in Patients With First Anterior Acute Myocardial Infarction
Authors: Shu Kasama, Takuji Toyama, Takashi Hatori, Hiroyuki Sumino, Hisao Kumakura, Yoshiaki Takayama, Shuichi Ichikawa, Tadashi Suzuki, Masahiko Kurabayashi
Journal: Journal of the American College of Cardiology (2007)
The place of analogy in Minimalist Morphology and the irregularity of regular forms
Authors: Dirk P. Janssen
Journal: Behavioral and Brain Sciences (1999)

Analogy plays an important role in the production of irregular forms but the proposed Minimalist Morphology (MM) representations do not express this. Recent results also show that the regular forms of strong paradigms can have idiosyncratic properties that cannot be accounted for by MM. Methodological problems with an experiment are discussed and a plea for a processing explanation is made.
Role of abnormally high transmural pressure in the permselectivity defect of glomerular capillary wall: a study in early passive Heymann nephritis.
Authors: T Yoshioka, H G Rennke, D J Salant, W M Deen, I Ichikawa
Journal: Circulation Research (1987)

To explore the mechanism of glomerular permselectivity defect in passive Heymann nephritis, an experimental model of human membranous glomerulopathy, Munich-Wistar rats were subjected to both micropuncture assessment of glomerular hemodynamics and whole kidney clearance measurements of graded size dextrans 10 days after injection of sheep anti-rat tubular antigen (anti-Fx1A). Compared with normal control rats, anti-Fx1A-treated animals were characterized by marked proteinuria (65 +/- 8 micrograms/min versus 6 +/- 1, p less than 0.001), markedly and significantly higher glomerular transcapillary hydraulic pressure difference (40 +/- 1 mm Hg versus 33 +/- 1, p less than 0.001), depressed ultrafiltration coefficient and impaired glomerular size-selective function as determined by fractional clearance of dextrans. Calculation of membrane parameters based on a recently defined heteroporous membrane model revealed abnormally high availability of non-size selective, large pore pathways in the glomerular capillary wall of the rats with passive Heymann nephritis. To ascertain the role of the altered hemodynamic pattern in the observed defect in the size-selective function of the glomerular capillary wall, glomerular transcapillary hydraulic pressure difference was manipulated experimentally in these proteinuric rats by intra-aortic infusion of acetylcholine or angiotensin II. These agents respectively suppressed and augmented glomerular transcapillary hydraulic pressure difference and brought about a decline of and a further rise in fractional clearance of larger dextrans along with parallel changes in both urine protein excretion rate and availability of nonselective channels. These results indicate that the permselectivity defect in passive Heymann nephritis is attributable, at least in part, to impaired size selectivity of the glomerular capillary wall caused by a prevailing abnormally high transcapillary hydraulic pressure difference.
SHORT- AND LONG-TERM OUTCOMES OF THREE APPROACHES TO CAROTID REVASCULARIZATION AMONG PATIENTS REQUIRING OPEN HEART SURGERY
Authors: Sridhar Venkatachalam, Samir R. Kapadia, Heather L. Gornik, Penny Houghtaling, Zhiyuan Sun, Christopher Bajzer, Bruce H. Gray, Daniel G. Clair, Joseph F. Sabik, Eugene H. Blackstone, Mehdi H. Shishehbor
Journal: Journal of the American College of Cardiology (2011)
THE TREATMENT OF DIPHTHERIA.Read before the Pennsylvania State Medical Society in May, 1892.
Authors: JOHN M. BATTEN
Journal: JAMA (1893)

I do not propose to offer anything new on this subject, but only to state a treatment that has been reasonably successful in my hands. In the fall of 1870, my attention was first directed to the efficacy of the calomel treatment in the socalled pseudo membranous croup in the following novel and somewhat accidental manner. This was before Dr. W. C. Reiter, of Pittsburgh, published his monograph on the treatment of diphtheria, and it was during a time when pseudo membranous croup was treated with emetics such as Turpeth mineral, ipecac, tartar emetic, and other relaxing remedies, drugs which I never was satisfied as to their efficacy and was always skeptical as to the benefit that might be derived from their use in the treatment of this disease. At the time above stated I was called to see a case suffering with the above named disease. The case was
Fulminant molluscum contagiosum infection and concomitant leukaemia cutis after bone marrow transplantation for chronic myeloid leukaemia
Authors: W.Y. Au, A.K.W. Lie, T.W. Shek
Journal: British Journal of Dermatology (2000)

Journal Article Fulminant molluscum contagiosum infection and concomitant leukaemia cutis after bone marrow transplantation for chronic myeloid leukaemia Get access W.Y. Au, W.Y. Au Departments of Medicine and *Pathology, Professorial Block, Queen Mary Hospital, Pokfulam Road, Hong KongE‐mail: auwing@hotmail.com Search for other works by this author on: Oxford Academic Google Scholar A.K.W. Lie, A.K.W. Lie Departments of Medicine and *Pathology, Professorial Block, Queen Mary Hospital, Pokfulam Road, Hong KongE‐mail: auwing@hotmail.com Search for other works by this author on: Oxford Academic Google Scholar T.W. Shek T.W. Shek Departments of Medicine and *Pathology, Professorial Block, Queen Mary Hospital, Pokfulam Road, Hong KongE‐mail: auwing@hotmail.com Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 143, Issue 5, 1 November 2000, Pages 1097–1098, https://doi.org/10.1046/j.1365-2133.2000.03859.x Published: 01 November 2000
LONG-TERM SKIN ALLOGRAFT SURVIVAL AFTER SHORT-TERM CYCLOSPORIN TREATMENT IN A PATIENT WITH MASSIVE BURNS
Authors: BruceM. Achauer, KirbyS. Black, KennethS. Waxman, CharlesW. Hewitt, SuzanneE. Martinez, RichardA. Ott, DavidW. Furnas
Journal: The Lancet (1986)
Array comparative genomic hybridization reveals genomic copy number changes associated with outcome in diffuse large B-cell lymphomas
Authors: Weiyi Chen, Jane Houldsworth, Adam B. Olshen, Gouri Nanjangud, Seeta Chaganti, Ennapadem S. Venkatraman, Jeffrey Halaas, Julie Teruya-Feldstein, Andrew D. Zelenetz, R. S. K. Chaganti
Journal: Blood (2005)
720-1 Incidence of and Factors Associated with Abrupt Closure in Patients Undergoing Elective, New Device Angioplasty in Native Coronary Arteries
Authors: Mun K. Hong, Jeffrey J. Popma, S. Chiu Wong, Kenneth M. Kent, Augusto D. Pichard, Lowell F. Satler, Ya Chien Chuang, Theresa A. Bucher, S. Shareghi, Martin B. Leon
Journal: Journal of the American College of Cardiology (1995)