THROMBOCYTOPENIA ASSOCIATED WITH THE ADMINISTRATION OF DIETHYLSTILBESTROL IN MAN
Authors: B A COOPER, F S BIGELOW
Journal: Annals of Internal Medicine (1960)

Case Reports1 April 1960THROMBOCYTOPENIA ASSOCIATED WITH THE ADMINISTRATION OF DIETHYLSTILBESTROL IN MANBERNARD A. COOPER, M.D., C. M., FREDERICK S. BIGELOW, M.D.BERNARD A. COOPER, M.D., C. M.Search for more papers by this author, FREDERICK S. BIGELOW, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-52-4-907 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptEstrogen administration has been reported to cause aplastic anemia in dogs,1, 2, 3 and in man has been associated infrequently either with hypoplastic anemia and thrombocytopenia,4, 5 or with purpura without thrombocytopenia.6, 7 In the case reported below, oral administration of diethylstilbestrol was promptly followed by thrombocytopenia and pruritus. The rarity of this sequence prompts this case report.CASE REPORTA thin, 88 year old white male entered the Boston City Hospital in November, 1957, for therapy of leg ulcers. Perineal prostatectomy had been performed one year previously for asymptomatic adenocarcinoma of the prostate. Physical examination was unremarkable except for...Bibliography1. Arnold O: Über die Wirkung des synthetischen Brunststoffes Diäthylstilböstrol auf das Knochenmark und Blut des Hundes, Klin. Wchnschr. 18: 891, 1939. CrossrefGoogle Scholar2. CastrodaleBierbaumHelwigMacBryde DOEBCM: Comparative studies of the effects of estradiol and stilbestrol upon the blood, liver, and bone marrow, Endocrinology 29: 363, 1941. CrossrefGoogle Scholar3. TyslowitzDingemanse RE: Effect of large doses of estrogens on the blood picture of dogs, Endocrinology 29: 817, 1941. CrossrefGoogle Scholar4. ChevallierUmdenstock PR: Myélophtisie mortelle après injections de benzoate d'oestradiol (folliculine cristallisée) à hautes doses chez une femme atteinte de prurit vulvaire sine materia, Sang 15: 528, 1943. Google Scholar5. WatsonSchultzWikoff CJALHM: Purpura following estrogen therapy, with particular reference to hypersensitivity to (diethyl) stilbestrol and with a note on the possible relationship of purpura to endogenous estrogens, J. Lab. and Clin. Med. 32: 606, 1947. MedlineGoogle Scholar6. Loftis EL: Purpura due to injection of estrogenic substance, Arch. f. Dermat. u. Syph. 42: 138, 1940. CrossrefGoogle Scholar7. Herbst WP: Thoughts and observations on the relation of altered hormonal balance to prostatic malignancy, Urol. and Cutan. Rev. 46: 691, 1942. Google Scholar8. BigelowDesforges FSJF: Platelet agglutination by an abnormal plasma factor in thrombocytopenic purpura associated with quinidine ingestion, Am. J. M. Sc. 224: 274, 1952. CrossrefMedlineGoogle Scholar9. Ackroyd JF: The cause of thrombocytopenia in Sedormid purpura, Clin. Sc. 8: 269, 1949. MedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Boston, Massachusetts*Received for publication November 10, 1958.From the Thorndike Memorial Laboratory and Second and Fourth (Harvard) Medical Services, Boston City Hospital, and the Department of Medicine, Harvard Medical School, Boston, Massachusetts.†Recipient of a National Research Fellowship in the Medical Sciences.Requests for reprints should be addressed to Frederick S. Bigelow, M.D., Thorndike Memorial Laboratory, Boston City Hospital, Boston 18, Massachusetts. 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