tbuckley/cabot-search huggingface dataset:
Long-Term Survival and Late Deaths after Allogeneic Bone Marrow Transplantation
Authors: Gérard Socié, Judith Veum Stone, John R. Wingard, Daniel Weisdorf, P. Jean Henslee-Downey, Christopher Bredeson, Jean-Yves Cahn, Jakob R. Passweg, Philip A. Rowlings, Harry C. Schouten, Hans-Jochem Kolb, Christine Bender-Götze, Bruce M. Camitta, Kamar Godder, Mary M. Horowitz, Alan S. Wayne, John P. Klein
Journal: New England Journal of Medicine (1999)

It is uncertain whether mortality rates among patients who have undergone bone marrow transplantation return to the level of the mortality rates of the general population. We analyzed the characteristics of 6691 patients listed in the International Bone Marrow Transplant Registry. All the patients were free of their original disease two years after allogeneic bone marrow transplantation. Mortality rates in this cohort were compared with those of an age-, sex-, and nationality-matched general population. Cox proportional-hazards regression was used to identify risk factors for death more than two years after transplantation (late death).Among patients who were free of disease two years after transplantation, the probability of living for five more years was 89 percent (95 percent confidence interval, 88 to 90 percent). Among patients who underwent transplantation for aplastic anemia, the risk of death by the sixth year after transplantation did not differ significantly from that of a normal population. Mortality remained significantly higher than normal throughout the study among patients who underwent transplantation for acute lymphoblastic leukemia or chronic myelogenous leukemia and through the ninth year among those who underwent transplantation for acute myelogenous leukemia. Recurrent leukemia was the chief cause of death among patients who received a transplant for leukemia, whereas chronic graft-versus-host disease was the chief cause among those who received a transplant for aplastic anemia. Advanced, long-standing disease before transplantation and active chronic graft-versus-host disease were important risk factors for late death.In patients who receive an allogeneic bone marrow transplant as treatment for acute myelogenous or lymphoblastic leukemia, chronic myelogenous leukemia, or aplastic anemia and who are free of their original disease two years later, the disease is probably cured. However, for many years after transplantation, the mortality among these patients is higher than that in a normal population.
Deficient interleukin-2 responsiveness of T lymphocytes from patients with primary biliary cirrhosis
Authors: José Luis Menéndez, José Antonio Girón, Luis Manzano, Aurelio Garrido, Luis Abreu, Agustin Albillos, Alberto Durántez, Melchor Alvarez-Mon
Journal: Hepatology (1992)

There is increasing evidence that primary biliary cirrhosis is associated with an alteration of the immune system. Although the cause remains unknown, it has been suggested that the immune system of patients with primary biliary cirrhosis is involved in the pathogenesis of their disease. We have investigated the T-cell function in patients with primary biliary cirrhosis and have found defective phytohemagglutinin-induced T-cell mitogenesis. Likewise, their blastogenic response to CD3 monoclonal antibody was also depressed, although the DNA synthesis induced by stimulation with phorbol esters (12-O-tetradecanoil-phorbol-13-acetate) plus ionophore (ionomycin) was normal. These alterations could not be ascribed either to a decreased synthesis of interleukin-2 or to a defective expression of interleukin-2 receptor after cellular activation. Moreover, this defective proliferative response of T lymphocytes was observed even in the presence of saturating concentrations of exogenous interleukin-2. These results represent evidence of the deficiency in the interleukin-2-dependent pathway found in T lymphocytes from patients with primary biliary cirrhosis.
Premature ventricular complex morphology. A marker for left ventricular structure and function.
Authors: K P Moulton, T Medcalf, R Lazzara
Journal: Circulation (1990)

The shape of a premature ventricular complex (PVC) might reflect the presence or absence of myocardial disease. To test this, 100 patients with a PVC on a 12-lead electrocardiogram at cardiac catheterization or nuclear angiography were classified according to PVC morphology. Group 1 (n = 50) had PVC QRS complexes with either smooth and uninterrupted contour or with narrow (less than 40 msec) notching. Group 2 (n = 50) demonstrated PVC with broad (greater than or equal to 40 msec) notching or shelves. Clinical, electrocardiographic and angiographic variables were assessed to define group differences. All patients had one or more etiological forms of heart disease none of which distinguished either group. Groups 1 and 2 differed with respect to a history of congestive heart failure (12% vs. 66%, p = 0.0004), dilated cardiomyopathy (2% vs. 38%, p = 0.0005), and the presence of mitral regurgitation (13% vs. 58%, p = 0.001), respectively. In group 1, 45 of 50 (90%) patients with a PVC had no notching. Patients in group 2 had greater PVC QRS duration as compared with patients in group 1 (181 +/- 6 vs. 134 +/- 3 msec, p = 0.0001). End-diastolic volume index (EDVI) (78 +/- 3 vs. 139 +/- 11 ml/m2, p = 0.0000) and ejection fraction (EF) (0.59 +/- 0.02 vs. 0.34 +/- 0.03, p = 0.0000) significantly discriminated between group 1 and 2, respectively.(ABSTRACT TRUNCATED AT 250 WORDS)
Augmented right ventricular function in systemic hypertension-induced hypertrophy
Authors: P. E. POOL, W. J. PIGGOTT, S. C. SEAGREN, C. L. SKELTON
Journal: Cardiovascular Research (1976)

Journal Article Augmented right ventricular function in systemic hypertension-induced hypertrophy Get access PETER E. POOL, PETER E. POOL From the Department of Medicine, School of Medicine, University of California, San Diego, La Jolla, California 92037 and the Pauline and Adolph Weinberger Laboratory for Cardiopulmonary Research of the Department of Internal Medicine, University of Texas Health Science Center at Dallas, Dallas, Texas 75235, USA Search for other works by this author on: Oxford Academic PubMed Google Scholar WILLIAM J. PIGGOTT, WILLIAM J. PIGGOTT From the Department of Medicine, School of Medicine, University of California, San Diego, La Jolla, California 92037 and the Pauline and Adolph Weinberger Laboratory for Cardiopulmonary Research of the Department of Internal Medicine, University of Texas Health Science Center at Dallas, Dallas, Texas 75235, USA Search for other works by this author on: Oxford Academic PubMed Google Scholar SHIRLEY C. SEAGREN, SHIRLEY C. SEAGREN From the Department of Medicine, School of Medicine, University of California, San Diego, La Jolla, California 92037 and the Pauline and Adolph Weinberger Laboratory for Cardiopulmonary Research of the Department of Internal Medicine, University of Texas Health Science Center at Dallas, Dallas, Texas 75235, USA Search for other works by this author on: Oxford Academic PubMed Google Scholar C. LYNN SKELTON C. LYNN SKELTON From the Department of Medicine, School of Medicine, University of California, San Diego, La Jolla, California 92037 and the Pauline and Adolph Weinberger Laboratory for Cardiopulmonary Research of the Department of Internal Medicine, University of Texas Health Science Center at Dallas, Dallas, Texas 75235, USA Search for other works by this author on: Oxford Academic PubMed Google Scholar Cardiovascular Research, Volume 10, Issue 1, January 1976, Pages 124–128, https://doi.org/10.1093/cvr/10.1.124 Published: 01 January 1976
Early transfer for angiography after fibrinolysis reduced ischemic events in patients with STEMI
Authors: Steven Borzak
Journal: Annals of Internal Medicine (2009)

ACP Journal Club17 November 2009Early transfer for angiography after fibrinolysis reduced ischemic events in patients with STEMISteven Borzak, MDSteven Borzak, MDUniversity of Miami Miller School of Medicine, Atlantis, Florida, USA (S.B.)Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-151-10-200911170-02004 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail Source CitationCantor WJ, Fitchett D, Borgundvaag B, et al. Routine early angioplasty after fibrinolysis for acute myocardial infarction. N Engl J Med. 2009;360:2705-18. https://pubmed.ncbi.nlm.nih.gov/19553646Clinical Impact RatingsEmergency Med: Hospitalists: Cardiology: References1 Antman EM, Anbe DT, Armstrong PW, et al. ACC/AHA guidelines for the management of patients with ST-elevation myocardial infarction: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines (Committee to Revise the 1999 Guidelines for the Management of Patients with Acute Myocardial Infarction). Circulation. 2004;110:e82-292. [PMID: 15339869] Google Scholar2 Verheugt FW. Routine angioplasty after fibrinolysis—how early should “early” be? N Engl J Med. 2009;360:2779-81. [PMID: 19553652] Google Scholar Author, Article, and Disclosure InformationAffiliations: University of Miami Miller School of Medicine, Atlantis, Florida, USA (S.B.)This article was published at Annals.org on 3 November 2009. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 17 November 2009Volume 151, Issue 10Page: JC5-4KeywordsAngiographyAngioplastyFibrinolysisHeart failureHemorrhageIschemiaPercutaneous coronary intervention ePublished: 17 November 2009 Issue Published: 17 November 2009 Copyright & PermissionsCopyright © 2009 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Clonal B-cell lymphocytosis exhibiting immunophenotypic features consistent with a marginal-zone origin: is this a distinct entity?
Authors: Aliki Xochelli, Christina Kalpadakis, Anne Gardiner, Panagiotis Baliakas, Theodoros P. Vassilakopoulos, Sarah Mould, Zadie Davis, Evangelia Stalika, George Kanellis, Maria K. Angelopoulou, Neil McIver-Brown, Rachel Ibbotson, Sotirios Sachanas, Penelope Korkolopoulou, Anastasia Athanasiadou, Achilles Anagnostopoulos, Helen A. Papadaki, Theodora Papadaki, Kostas Stamatopoulos, Gerassimos A. Pangalis, David Oscier
Journal: Blood (2013)
Viral infections in relation to age, atopy, and season of admission among children hospitalized for wheezing
Authors: Peter W Heymann, Holliday T Carper, Deborah D Murphy, Thomas A.E Platts-Mills, James Patrie, Anne P McLaughlin, Elizabeth A Erwin, Marcus S Shaker, Martha Hellems, Jehanna Peerzada, Frederick G Hayden, Tina K Hatley, Rachel Chamberlain
Journal: Journal of Allergy and Clinical Immunology (2004)

BackgroundViral respiratory tract infections and atopy are associated with attacks of wheezing during childhood. However, information about the relationship between viral infections and atopy among children whose attacks of wheezing lead to hospitalization is unclear.ObjectiveTo evaluate the prevalence of viral respiratory tract pathogens among infants and children hospitalized for wheezing and to analyze the results in relation to the patient's age, atopic characteristics, and season of admission.MethodsThis was a case-control study of children (age 2 months to 18 years) admitted for wheezing to the University of Virginia Medical Center over a period of 12 months. Children without wheezing were enrolled as controls. Nasal secretions were evaluated for viral pathogens by using cultures, PCR tests, and antigen detection. Total IgE and specific IgE antibody to common aeroallergens was measured in serum.ResultsSeventy percent of children hospitalized for wheezing before age 3 years (n = 79) were admitted between December and March, whereas 46% of children age 3 to 18 years (n = 54) were hospitalized between September and November. Among children younger than 3 years, viral pathogens were detected in 84% (66/79) of wheezing children and 55% (42/77) of controls (P < .001). Respiratory syncytial virus was the dominant pathogen during the winter months, but rhinovirus was more common during other months. Total serum IgE levels were generally low, and values from wheezing and control subjects overlapped considerably. Among children 3 years and older, 61% (33/54) of subjects admitted for wheezing tested positive for virus (predominantly rhinovirus), compared with 21% (12/56) of controls (P < .001). The total serum IgE values among wheezing children (geometric mean, 386 IU/mL; 95% CI, 259-573) were substantially elevated compared with those of controls (geometric mean, 38 IU/mL; 95% CI, 26-56; P < .001). A significantly higher percentage of wheezing children compared with controls was sensitized to at least 1 of the inhaled allergens tested: 84% (36/43) compared with 33% (15/45; P < .001). The atopic characteristics of wheezing children who tested positive or negative for virus were similar.ConclusionsViral infections were the dominant risk factor for wheezing among children hospitalized before 3 years of age. By comparison, a large majority of the wheezing children age 3 to 18 years had striking atopic characteristics that may be critical as a risk factor for hospitalization and an adverse response to viral infections, especially infections caused by rhinovirus.
Sulindac increases the expression of APC mRNA in malignant colonic epithelial cells: an in vitro study.
Authors: M Schnitzler, T Dwight, B G Robinson
Journal: Gut (1996)

BACKGROUND--Sulindac is a non-steroidal anti-inflammatory drug which induces regression of colonic polyps in patients with familial adenomatous polyposis. Animal and in vitro studies have shown that both the sulphide metabolite of sulindac, which is able to inhibit cyclo-oxygenase, and the sulphone metabolite, which lacks this ability, are able to inhibit the growth of colonic carcinoma cells. The exact mechanism by which these effects occurs is not known. AIMS--To examine the effect of sulindac sulphide and sulindac sulphone on the expression of APC messenger RNA (mRNA), and on the proliferation of colonic carcinoma cells in vitro. METHODS--The colonic carcinoma cell line LIM 1215 was treated with sulindac sulphide and sulindac sulphone (10 microM or 100 microM) for 24 hours. Total RNA was extracted and APC mRNA was quantitated using competitive reverse transcription polymerase chain reaction. Measurements of cell number, cell proliferation, and prostaglandin E2 concentrations were also made. RESULTS--A significant increase in APC mRNA was observed after treatment with 10 microM of both sulindac sulphide and sulindac sulphone (control: 37.2 (19.7); 10 microM sulindac sulphide: 129 (112.8); 10 microM sulindac sulphone: 207.7 (102.9) pg/(g total RNA) (p &lt; 0.05). Prostaglandin E2 concentrations were significantly reduced after treatment with sulindac sulphide, but not after sulindac sulphone. Both agents produced a dose dependent reduction in cell numbers and cell proliferation, which was more noticeable after treatment with sulindac sulphide. CONCLUSIONS--Both sulindac sulphide and sulindac sulphone inhibit the growth of carcinoma cells in vitro and cause an increase in APC mRNA. The effect of these agents on colonic carcinogenesis is not mediated entirely by means of an inhibition of prostaglandin biosynthesis.
The Flavonoid 7,4'- Dihydroxyflavone Inhibits Human Airway Epithelial Cells MUC5AC Mucin Production Via Regulation of NF-êb, STAT6 and HDAC2
Authors: Changda Liu, David Weir, Swathi Chakrapani, Paula J. Busse, Nan Yang, Zhenwen Zhou, Charles W. Emala, Xiu-Min Li
Journal: Journal of Allergy and Clinical Immunology (2015)
Role of synectin in lymphatic development in zebrafish and frogs
Authors: Karlien Hermans, Filip Claes, Wouter Vandevelde, Wei Zheng, Ilse Geudens, Fabrizio Orsenigo, Frederik De Smet, Evisa Gjini, Kristof Anthonis, Bin Ren, Dontcho Kerjaschki, Monica Autiero, Annelii Ny, Michael Simons, Mieke Dewerchin, Stefan Schulte-Merker, Elisabetta Dejana, Kari Alitalo, Peter Carmeliet
Journal: Blood (2010)
Peak Exercise Oxygen Consumption in Chronic Heart Failure: Toward Efficient Use in the Individual Patient
Authors: Cristina Opasich, Gian Domenico Pinna, Marco Bobbio, Massimo Sisti, Brunella Demichelis, Oreste Febo, Giovanni Forni, Roberto Riccardi, P.Giorgio Riccardi, Soccorso Capomolla, Franco Cobelli, Luigi Tavazzi
Journal: Journal of the American College of Cardiology (1998)
1027-188 Relationship of polymorphisms in the oxidative stress-related genes—paraoxonase and p22phox—to variant angina and coronary artery stenosis
Authors: Young-Seok Cho, Hyo-Soo Kim, Shu-Ying Zhang, Byung-Hee Oh, Myoung-Mook Lee, Young-Bae Park, Yun-Shik Choi
Journal: Journal of the American College of Cardiology (2004)
Haemophilus aphrophilus endocarditis.
Authors: K Zinnemann
Journal: BMJ (1970)

SIR,-Your leading article on Crohn's Disease and its Consequences (11 April p. 65) says "Psychological factors are gener- ally held not to be aetiologically important" and cites to support such a "generally held" view but one reference, and that to an article which has been much criticised on account of its methodology.Dare I suggest that such selectivity if practised by psychiatrists would quite prop- erly call down the wrath of medical science?To redress the balance I draw your atten- tion to a few recent articles giving the opposite view.'-'-I am, etc.,
Moonlighting: Wax Without the Wane
Authors: Clinton B. Seeley
Journal: JAMA (1964)

<h3>To the Editor:—</h3> Dr. Trimble concluded his remarks on moonlighting (Critique and Cavil,<i>JAMA</i><b>189:</b>538 [Aug 17] 1964) with the question, "Well—what do you think?" Well, this is what I think: Most residents are driven to moonlighting by the pressure of economic necessity. Virtually no one would do it if he were paid $25,000 a year. Most moonlighters stop their extracurricular work the moment they get fellowships or staff appointments paying as little as 20% of that figure. In my own experience, the added income was the difference between solvency and the now-popular alternative of deliberate deficit spending. My strongest disagreement is with the quote, "The resident who subordinates intellectual solvency to financial gain during his graduate training period may discover too late that he paid too much for his whistle." The implication is that any knowledge or experience gained in moonlighting is valueless or even detrimental. This is
Radiologic Special Procedures Privileges
Authors: Marshall Rowen
Journal: JAMA (1972)

Rules governing the granting of privileges for the performance of radiologic special procedures provide for limited privileges under observation, leading to full privileges after specific criteria are met. Considerations include indication for the examination, technical performance of the procedure, and radiographic control. In certain instances, a single individual might be responsible and capable in all of these aspects, whereas in other cases, this may involve multiple disciplines. After three years, the widespread endorsement of this approach by the hospital staffs and the enthusiasm shown by other radiologists involved in special procedures are excellent indications of its value.
Case of Cephaloma, Cured in the Foot, Subsequently Developed in Various Internal Organs
Authors: Richard Francis George
Journal: BMJ (1845)

CASE O CEPHALOMA.63t a buffy coat with wlhitish strie; twice with greyish stri only; once it was of a brownish red.Second Blood-lektings.-Theproportion of globules was here still more notably diminished.The albumen preserved the same low figure, and the fibrin was a little less than what it was on the first venesection.The fatty matters varied but little, except the cholesterine, which was in every case increased.The phosphates were very abundant.These results were manifested without exception, in the three second blood-lettings.It shouild be added, that the serum was once slightly, once considerably, and once very abundant; and in -ll three cases slightly turbid.The clot was voluminous and resistant in each; twice it was buffed with stria; tnce it only presented whitish strise.
On the Measurement of Alexithymic Behavior
Authors: F. Lolas, G. de la Parra, S. Aronsohn, C. Collin
Journal: Psychotherapy and Psychosomatics (1980)

It is suggested in this paper that alexithymia may be a graded behavioral characteristic in much the same way as psychological dimensions are. Under this assumption every person would possess an alexithymic score, however low it could be, and the basis for distinguishing between diagnostic groups would thence be quantitative rather than qualitative. The measurement of alexithymia in any given individual poses two main problems: the nature of the underlying phenomenon and the instruments that should be used for its depiction. Whether alexithymia is a trait, a state, or both cannot be answered confidently at present. On the other hand, its quantitative assessment depends upon an interaction between phenomenon, observer and situation. Some data bearing on the application of the Beth Israel Alexithymic and Psychosomatic Questionnaire by informed and uninformed interviewers suggest the need for reliability studies of this instrument. Also advanced is the possibility that some aspects of the syndrome (reflected differently in the questionnaire items) might be easier to detect or more amenable to quantitative assessment, thus suggesting that some weighting of items is needed in order to obtain a total alexithymia score.
AMOEBIASIS CUTIS FOLLOWING SURGICAL DRAINAGE OF A LARGE HEPATIC, SUBPHRENIC AND PERINEPHRIC ABSCESS
Authors: SIMON BOR, A. E. THOMPSON, JOHN GUTHRIE
Journal: British Journal of Dermatology (1969)

SUMMARY.— A case of amoebiasis cutis following surgical drainage of a large hepatic, subphrenic and perinephric abscess is reported. The patient was an Australian-born housewife who had been resident in England for 4 years. She was taking oral corticosteroids for the relief of atopic eczema; the possible role of steroids in unmasking latent amoebiasis is discussed.