tbuckley/cabot-search huggingface dataset:
Tolerogenic dendritic cells for autoimmune disease and transplantation
Authors: A W Thomson, P D Robbins
Journal: Annals of the Rheumatic Diseases (2008)

Dendritic leucocytes are professional antigen-presenting cells with inherent tolerogenic properties and are regarded as critical regulators of innate and adaptive immunity. Modification of dendritic cells (DCs) in the laboratory can enhance and stabilise their tolerogenic properties. Numerous reports suggest that such immature, maturation-resistant or "alternatively activated" DCs can regulate autoreactive or alloreactive T-cell responses and promote or restore antigen-specific tolerance in experimental animal models. The first clinical testing of tolerogenic DCs in human autoimmune disease, including rheumatoid arthritis, is imminent. Herein the properties of tolerogenic DCs and prospects for their testing in chronic inflammatory disease and transplantation are reviewed.
TCT-133 Role of arterial stiffness and impaired renal function in the progression of non-culprit coronary lesions after percutaneous coronary intervention
Authors: Hidehiro Kaneko, Junji Yajima, Yuji Oikawa, Shunsuke Matsuno, Shingo Tanaka, Daisuke Fukamachi, Shinya Suzuki, Tadanori Aizawa, Takeshi Yamashita
Journal: Journal of the American College of Cardiology (2012)
ALKALIN ANTISEPTIC TABLETS.
Authors: HENRY W. WANDLESS
Journal: JAMA (1897)

Each tablet is composed of the following: Acid boracic, grs. 22.5; sodiibicarb., grs. 7.5; sodii biborat., grs. 7.5; camphor, grs. 1⅞; menthol, grs. 1⅞; thymol, gr..5 combined with three minims of the following combinations of oils: Oil pinus pinolias, 2 parts; oil eucalyptus, 2 parts; oil Scotch pine, 2 parts; oil spruce, 1 part; oil cedar, 1 part; oil cubebs, 1 part; oil wintergreen,.25 part; oil bay leaves .25 part; chloroform, 2 parts. These tablets are very useful in the treatment of catarrhal conditions of the nose, throat and ear. They are used by dissolving them in hot water and used as a douche or spray, and are sometimes useful dissolved in the mouth in cases of sore throat and troublesome cough caused by irritation of the larynx. One of these tablets dissolved in one or two ounces of boiling water will make a very agreeable wash or spray for the
New application of direct sinus node recordings in man: assessment of sinus node recovery time.
Authors: J A Gomes, R I Hariman, I A Chowdry
Journal: Circulation (1984)

Sinus node recovery time (SNRT) is frequently used to assess sinus node function in patients with suspected sick sinus syndrome (SSS). Although SNRT is assumed to reflect sinus node automaticity, this assumption remains unproven. The purpose of this study was (1) to test the hypothesis that SNRT in patients with and without SSS reflects sinus node automaticity, and (2) to assess the role of sinoatrial conduction time in the measurement of SNRT. A total of 16 patients (mean +/- SD age 63 +/- 9 years), seven of which had SSS, form the basis of this report. An electrogram of the sinus node was obtained for each of the 16 patients, and overdrive pacing was performed in each at cycle lengths of 1000 to 300 msec. SNRT was measured (1) on the sinus node electrogram (direct method, measuring SNRTd) as the interval from the last pacing stimulus artifact to the onset of the upstroke slope of first postpacing sinus beat and (2) on the high right atrial electrogram (indirect method, measuring SNRTi). Results were as follows: (1) The longest SNRTd was significantly shorter than the longest SNRTi (989 +/- 304 vs 1309 +/- 356 msec, p less than .001). (2) For the first postpacing sinus beat there was a significant prolongation of sinoatrial conduction time as compared with that for sinus beats before pacing (319 +/- 152 vs 99 +/- 35 msec, p less than .001). Sinoatrial conduction time normalized within 3.6 +/- 0.96 postpacing sinus beats. (3) At the pacing cycle length that resulted in the longest recovery time, sinus node depression was seen in 56% of patients, sinus node acceleration was noted in 26%, and no appreciable change in sinus node automaticity was observed in 19%. (4) Sinoatrial conduction time for the sinus beat before pacing and that for the first postpacing beat was longer in patients with SSS when compared with in patients without SSS. (5) In patients with SSS the abnormal SNRTi, when corrected for the degree of prolongation of sinoatrial conduction time for the first postpacing beat, became normal in five of six patients. We conclude that (1) SNRTi reflects both sinus node automaticity and sinoatrial conduction time, whereas SNRTd reflects sinus node automaticity, (2) overdrive atrial pacing results in marked prolongation of sinoatrial conduction time for the first postpacing beat, which is longer in patients with SSS when compared with in those without SSS, and (3) in patients with SSS the inference of abnormal sinus node automaticity on the basis of a prolonged corrected SNRTi is usually incorrect.
Potential limitations of a conical spacer device in severe asthma.
Authors: I D Cox, P J Wallis, M C Apps
Journal: BMJ (1984)

L'appareil «Nebuhaler» est concu pour administrer un aerosol de bronchodilatateur dans l'asthme, mais son fonctionnement correct demande un debit expiratoire suffisant pour qu'une valvule se referme. Si ce debit est insuffisant la valvule reste ouverte et l'aerosol est perdu a l'exterieur
Mechanical properties of the ascending thoracic aorta of man
Authors: E. R. GOZNA, A. E. MARBLE, A. J. SHAW, D. A. WINTER
Journal: Cardiovascular Research (1973)

Journal Article Mechanical properties of the ascending thoracic aorta of man Get access E. R. GOZNA, E. R. GOZNA From the Departments of Surgery, and Radiology, Dalhousie University and the Victoria General Hospital, and the Department of Electrical Engineering, Nova Scotia Technical College, Halifax, Nova Scotia, Canada Search for other works by this author on: Oxford Academic PubMed Google Scholar A. E. MARBLE, A. E. MARBLE From the Departments of Surgery, and Radiology, Dalhousie University and the Victoria General Hospital, and the Department of Electrical Engineering, Nova Scotia Technical College, Halifax, Nova Scotia, Canada Search for other works by this author on: Oxford Academic PubMed Google Scholar A. J. SHAW, A. J. SHAW From the Departments of Surgery, and Radiology, Dalhousie University and the Victoria General Hospital, and the Department of Electrical Engineering, Nova Scotia Technical College, Halifax, Nova Scotia, Canada Search for other works by this author on: Oxford Academic PubMed Google Scholar D. A. WINTER D. A. WINTER From the Departments of Surgery, and Radiology, Dalhousie University and the Victoria General Hospital, and the Department of Electrical Engineering, Nova Scotia Technical College, Halifax, Nova Scotia, Canada Search for other works by this author on: Oxford Academic PubMed Google Scholar Cardiovascular Research, Volume 7, Issue 2, March 1973, Pages 261–265, https://doi.org/10.1093/cvr/7.2.261 Published: 01 March 1973
P75 Clinical predictors of continuous positive airway pressure requirement in bronchiolitis
Authors: J. Evans, M. Marlais, E. Abrahamson
Journal: Thorax (2010)

<h3>Background</h3> Bronchiolitis is the commonest respiratory viral illness in infants with the potential for significant morbidity. There is growing evidence for the use of continuous positive airway pressure (CPAP) non-invasive ventilation in the most seriously affected of these children. Despite the increasing literature regarding the use of CPAP there are currently no studies which identify clinical predictors of requirement for CPAP using the UK bronchiolitis age limit of 12 months, leaving the decision to clinical judgement alone. <h3>Objective</h3> To identify clinical factors in infants with bronchiolitis at the time of presentation to the emergency department, which might predict a requirement for CPAP following admission. <h3>Methods</h3> Retrospective review of paediatric emergency department case notes was conducted on all bronchiolitis admissions to one tertiary paediatric emergency department in a 12-month period (April 2009–March 2010). Inclusion criteria consisted of a clinical diagnosis of bronchiolitis in those 12 months of age or under. Potential clinical predictors were identified through an extensive literature review. Data extraction of these predetermined potential clinical predictors was carried out and recorded for each case. Logistic regression was then conducted for each variable to identify statistically significant independent predictors of CPAP requirment. <h3>Results</h3> During the study period 163 infants were admitted with acute bronchiolitis. Of the 163 infants admitted 28 (17%) received CPAP. The most significant predictors of CPAP requirement in those admitted were as follows: lower oxygen saturation (mean 92.7% vs 97.1%, p&lt;0.001), oxygen requirement in the emergency department (89.3% vs 24.4%, p&lt;0.001), lower weight at presentation (mean 4221 g vs 6668 g, p&lt;0.001), higher capillary blood gas PaCO<sub>2</sub> (mean 8.32 kPa vs 6.05 kPa, p&lt;0.001) and higher capillary blood gas HCO<sub>3</sub><sup>-</sup> (mean 30.5 mmol/l vs 26.5 mmol/l, p&lt;0.001). <h3>Conclusion</h3> We have identified a number of clinical variables which may be assessed within the emergency department, each independently predictive of CPAP requirement in those who are admitted with bronchiolitis. These findings are of particular importance as an aid to clinical assessment of bronchiolitis severity. They are also likely to have a useful role in logistical management decisions, allowing early planning for non-invasive ventilation.
Abstract P3-02-04: QM-FISH analysis of the genes involved in the G1/S checkpoint signaling pathway in triple-negative breast cancer
Authors: J Zhang, S Zhang, G Hou, Y Shao, X Zhang
Journal: Cancer Research (2013)

Abstract OBJECTIVES: To analyze copy number alterations(CNAs) of the genes involved in the G1/S checkpoint signaling pathway of triple-negative breast cancer (TNBC) and non- triple-negative breast cancer(non-TNBC) and in order to find specific CNAs associated with overall survive for TNBC.In all,to provide an effective target for future treatment. METHODS: We selected the samples randomly form Tianjin Cancer Hospital between August, 2006 and August, 2007,which contained one hundred TNBC cases and one hundred non-TNBC cases. Quantitative mμlti-gene fluorescence in situ hybridization (QM-FISH) was used to study CNAs of the genes involved in the G1/S checkpoint signaling pathway, including CCND1,c-Myc,p21, CHEK2, p16, Rb1, Mdm2and p53. RESULTS: The amplification rates of c-Myc and the deletion rates of p53 in TNBC tended to be higher than those in non-TNBC, whereas the amplification rates of CCND1 and Mdm2 in non-TNBC tended to be higher than those in TNBC. In Kaplan-Meier analysis, the amplification of CCND1 (P = 0.02) and c-Myc (P = 0.02) as well as the deletion of p53 (P = 0.01) predicted worse survival in the TNBC group. While in the non-TNBC group, the amplification of CCND1 (P = 0.01) and Mdm2 (P = 0.04) as well as the deletion of p53 (P = 0.049) were associated with worse survival. The amplification of c-Myc and the deletion of p53 in TNBC were associated with higher mortality risk (HR,2.87;95%CI,1.14-7.21[P = 0.03]; HR, 3.34;95%CI, 1.22-9.09 [P = 0.02]), whereas the mortality risk tended to be higher in the patients with amplification of CCND1 (HR, 4.35;95%CI,1.23-15.39 [P = 0.02])in non-TNBC. CONCLUSIONS: The amplification rates of c-Myc and deletion rates of p53 in TNBC tended to be higher than those in non-TNBC, whereas the amplification rate of CCND1 and Mdm2 tended to be higher in non-TNBC. c-Myc and p53 were independent prognostic factors for TNBC, while CCND1 was the independent prognostic factors for non-TNBC. Citation Information: Cancer Res 2013;73(24 Suppl): Abstract nr P3-02-04.
Time Course and Recovery of Exacerbations in Patients with Chronic Obstructive Pulmonary Disease
Authors: TERENCE A. R. SEEMUNGAL, GAVIN C. DONALDSON, ANGSHU BHOWMIK, DONALD J. JEFFRIES, JADWIGA A. WEDZICHA
Journal: American Journal of Respiratory and Critical Care Medicine (2000)

Although exacerbations of chronic obstructive pulmonary disease (COPD) are associated with symptomatic and physiological deterioration, little is known of the time course and duration of these changes. We have studied symptoms and lung function changes associated with COPD exacerbations to determine factors affecting recovery from exacerbation. A cohort of 101 patients with moderate to severe COPD (mean FEV1 41.9% predicted) were studied over a period of 2.5 yr and regularly followed when stable and during 504 exacerbations. Patients recorded daily morning peak expiratory flow rate (PEFR) and changes in respiratory symptoms on diary cards. A subgroup of 34 patients also recorded daily spirometry. Exacerbations were defined by major symptoms (increased dyspnea, increased sputum purulence, increased sputum volume) and minor symptoms. Before onset of exacerbation there was deterioration in the symptoms of dyspnea, sore throat, cough, and symptoms of a common cold (all p < 0.05), but not lung function. Larger falls in PEFR were associated with symptoms of increased dyspnea (p = 0.014), colds (p = 0.047), or increased wheeze (p = 0.009) at exacerbation. Median recovery times were 6 (interquartile range [IQR] 1 to 14) d for PEFR and 7 (IQR 4 to 14) d for daily total symptom score. Recovery of PEFR to baseline values was complete in only 75.2% of exacerbations at 35 d, whereas in 7.1% of exacerbations at 91 d PEFR recovery had not occurred. In the 404 exacerbations where recovery of PEFR to baseline values was complete at 91 d, increased dyspnea and colds at onset of exacerbation were associated with prolonged recovery times (p < 0.001 in both cases). Symptom changes during exacerbation do not closely reflect those of lung function, but their increase may predict exacerbation, with dyspnea or colds characterizing the more severe. Recovery is incomplete in a significant proportion of COPD exacerbations.
Quantitation of fragment X formation during thrombolytic therapy with streptokinase and tissue plasminogen activator.
Authors: J Owen, K D Friedman, B A Grossman, C Wilkins, A D Berke, E R Powers
Journal: Journal of Clinical Investigation (1987)

We have determined the extent of fragment X formation during thrombolytic therapy by integration over time of the plasma fibrinopeptide B beta 1-42 concentration. This peptide is quantitatively released when fragment X is formed by plasmin action on fibrinogen or fibrin I. In response to streptokinase (SK) and rt-PA, 264 +/- 54 and 95 +/- 12 mg/dl respectively of fibrinogen was converted to fragment X. By immunoblotting, fragment X was demonstrated as early as 5 min after SK and 30 min after rt-PA, and was still evident 24 h after treatment. Patients treated with SK showed extensive further plasmin degradation of fragment X to fragments Y and D. Thus fragment X concentrations tend to be more similar in the two groups than would be expected from the extent of fibrinogen breakdown. Fragment X forms clots, but these have lower tensile strength and are more susceptible to further plasmin lysis than clots of fibrin. Thus the similar bleeding observed in the two treatment groups might be a reflection of their similar plasma fragment X concentrations.
THE PROCESS OF FORCED DILATATION WITH IMPACTED NEBULA.AUXILIARY TO THE MEDICAL AND SURGICAL TREATMENT OF THE EARS, NOSE, THROAT AND CHEST, WITH ILLUSTRATIONS OF PORTABLE APPARATUS. SOME SUGGESTION TO GENERAL PRACTITIONERS AS TO THE SELECTION OF MEDICINAL AGENTS AND AS TO MEASURES FOR CONTROLLING PULMONARY DISEASES.
Authors: GEORGE F. HAWLEY
Journal: JAMA (1895)

Through new discoveries and improved methods for preventing diseases and restoring health, the general and special practice of medicine and surgery is gradually becoming a practical if not a positive science. While marked progress has been made all along the lines of general, and in some lines of special practice, it is a lamentable fact that there have been but few improvements in the facilities, and none in the methods, of treating diseases of the air passages locally, for the past ten or fifteen years, until the discovery of a new process for preparing and administering impacted nebula by forced dilatation, and the invention of an instrument for accomplishing the same. With the exception of this discovery and invention, the means and measures employed at the present time in the local treatment of the air passages are identical with those of the past. In a former paper entitled, "A New
Hydrogen peroxide release by alveolar macrophages from sarcoid patients and by alveolar macrophages from normals after exposure to recombinant interferons alpha A, beta, and gamma and 1,25-dihydroxyvitamin D3.
Authors: A O Fels, C F Nathan, Z A Cohn
Journal: Journal of Clinical Investigation (1987)

We measured H2O2 release by human alveolar macrophages (AM) from normals and sarcoid patients in suspension immediately after bronchoalveolar lavage in the presence and absence of the triggering agent, phorbol myristate acetate (PMA). AM from 11 sarcoid patients produced a mean (+/- SE) of 21.7 +/- 2.3 and 5.9 +/- 3.4 nmol H2O2/10(6) macrophages in the presence and absence of PMA, respectively. By contrast, AM from normals (n = 6) produced 9.8 +/- 1.7 and 1.6 +/- 0.7 nmol H2O2/10(6) macrophages with and without PMA, respectively. Macrophage activation, as monitored by H2O2 production, did not correlate with the angiotensin-converting enzyme levels, the result of gallium-67 scans, or the percent of lymphocytes in the bronchoalveolar lavage. To determine whether AM from normals could be stimulated to increase their H2O2 production to the level seen in patients with sarcoid, we measured H2O2 released by adherent AM after incubation in each of four potential activating agents: recombinant interferons alpha A, beta, gamma (rIFN alpha A, rIFN beta, and rIFN gamma, respectively), and 1,25-dihydroxyvitamin D3. H2O2 release in the range seen in sarcoid patients could be induced in PMA-triggered AM from normals by rIFN gamma in a time- (t1/2 approximately 1 d) and dose-dependent fashion (threefold increase, EC50 5 antiviral U/ml) and by rIFN alpha A and rIFN beta at higher concentrations, but not by 1,25-dihydroxyvitamin D3.
Genetics and the clinical response to warfarin and edoxaban: findings from the randomised, double-blind ENGAGE AF-TIMI 48 trial
Authors: Jessica L Mega, Joseph R Walker, Christian T Ruff, Alexander G Vandell, Francesco Nordio, Naveen Deenadayalu, Sabina A Murphy, James Lee, Michele F Mercuri, Robert P Giugliano, Elliott M Antman, Eugene Braunwald, Marc S Sabatine
Journal: The Lancet (2015)
Characteristics of Patients and Medical Care in New Haven Area Nursing Homes
Authors: John O. Pastore, Fredrick B. Winston, Harold S. Barrett, Franklin M. Foote
Journal: New England Journal of Medicine (1968)

THERE is widespread ignorance in the medical community today concerning nursing homes —their patients, their potentialities and their special problems. Moreover, it is only in the last 15 years that anything resembling a real effort has been undertaken to lessen this ignorance. The reasons for this situation have been many and varied.First of all, nursing homes have flourished only since 1935, when the Social Security Act made available substantial public-assistance hinds for the aged. Recently published data indicate that 700,000 persons reside in "nursing homes and related facilities."1 Another factor has been the opinion of medical personnel that nursing . . .
Acute Migraine Treatment Guideline
Authors: Catherine Marino
Journal: Annals of Internal Medicine (2003)

Letters7 October 2003Acute Migraine Treatment GuidelineCatherine Marino, MDCatherine Marino, MDFrom New Jersey Medical SchoolUniversity of Medicine & Dentistry of New Jersey; Newark, NJ 07103.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-139-7-200310070-00025 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:I have had migraines for 30 years and therefore read Snow and colleagues' article on migraine management and prevention (1) with interest. I have used almost all of the medications mentioned in the article and continue to get migraines at least once per week, sometimes twice. My migraines are characterized by nausea, occasional vomiting, photophobia, and intense right-side frontal pain, along with a sense of unease. There is no aura. The triptans I have takensumatriptan, naratriptan, and rizatriptando work with varying onset of action and sometimes rebound pain. I have also used acetaminophen, butalbital, and caffeine (Fioricet, ...References1. Snow V, Weiss K, Wall EM, Mottur-Pilson C. Pharmacologic management of acute attacks of migraine and prevention of migraine headache. Ann Intern Med. 2002;137:840-9. [PMID: 12435222] LinkGoogle Scholar2. Binder WJ, Brin MF, Blitzer A, Schoenrock LD, Pogoda JM. Botulinum toxin type A (BOTOX) for treatment of migraine headaches: an open-label study. Otolaryngol Head Neck Surg. 2000;123:669-76. [PMID: 11112955] CrossrefMedlineGoogle Scholar3. Troost TB. Presented at Annual Meeting of the American Headache Society, Seattle, Washington, 18 June 2002. Google Scholar4. Silberstein SD. Review of botulinum toxin type A and its clinical applications in migraine headache. Expert Opin Pharmacother. 2001;2:1649-54. [PMID: 11825307] CrossrefMedlineGoogle Scholar5. Goadsby PJ, Lipton RB, Ferrari MD. Migrainecurrent understanding and treatment. N Engl J Med. 2002;346:257-70. [PMID: 11807151] CrossrefMedlineGoogle Scholar Author, Article, and Disclosure InformationAffiliations: From New Jersey Medical SchoolUniversity of Medicine & Dentistry of New Jersey; Newark, NJ 07103. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoPharmacologic Management of Acute Attacks of Migraine and Prevention of Migraine Headache Vincenza Snow , Kevin Weiss , Eric M. Wall , Christel Mottur-Pilson , and Acute Migraine Treatment Guideline Vincenza Snow Metrics Cited ByMigräneMigräne 7 October 2003Volume 139, Issue 7Page: 603KeywordsBotulinum toxinHeadachesHormone replacement therapyMenopauseMigraineNauseaNervous systemSleepTreatment guidelinesVomiting ePublished: 7 October 2003 Issue Published: 7 October 2003 CopyrightCopyright © 2003 by American College of Physicians. All Rights Reserved.PDF DownloadLoading ...
A dim monocular view of Universal-Grammar access
Authors: Derek Bickerton
Journal: Behavioral and Brain Sciences (1996)

Abstract This target article's handling of theory and data and the range of evidence surveyed for its main contention fall short of normal BBS standards. However, the contention itself is reasonable and can be supported if one rejects the “knowledge” metaphor for linguistic competence and accepts that “syntactic principles” are no more than the way the brain does language.