tbuckley/cabot-search huggingface dataset:
Abstract 12830: Sodium Bicarbonate Therapy for the Prevention of Contrast-Induced Nephropathy: An Updated Meta-Analysis
Authors: Jae-Sik Jang, Sang-Ryul Chung, Han-Young Jin, Jeong-Sook Seo, Tae-Hyun Yang, Dae-Kyeong Kim, Bomin Park, Ki-Hun Kim, Dong-Kie Kim, Sang-Hoon Seol, Doo-Il Kim, Kyoung-Im Cho, Bo-Hyun Kim, Hyoung-Gon Je, Yong-Hyun Park, Dong-Soo Kim
Journal: Circulation (2011)
Survivorship: Introduction and Definition
Authors: Crystal S. Denlinger, Robert W. Carlson, Madhuri Are, K. Scott Baker, Elizabeth Davis, Stephen B. Edge, Debra L. Friedman, Mindy Goldman, Lee Jones, Allison King, Elizabeth Kvale, Terry S. Langbaum, Jennifer A. Ligibel, Mary S. McCabe, Kevin T. McVary, Michelle Melisko, Jose G. Montoya, Kathi Mooney, Mary Ann Morgan, Tracey O’Connor, Electra D. Paskett, Muhammad Raza, Karen L. Syrjala, Susan G. Urba, Mark T. Wakabayashi, Phyllis Zee, Nicole McMillian, Deborah Freedman-Cass
Journal: Journal of the National Comprehensive Cancer Network (2014)

Many cancer survivors experience physical and/or psychosocial side effects, which can be severe, debilitating, and sometimes permanent. These NCCN Guidelines for Survivorship provide screening, evaluation, and treatment recommendations for common consequences of cancer and cancer treatment for health care professionals who work with survivors of adult-onset cancer in the posttreatment period. These introductory sections of the guidelines include the panel's definition of cancer survivors, a discussion of the effects of cancer and its treatment, general principles and standards for survivorship care, and guidance regarding screening for problems that require further assessment.
Abstract 12179: Predictors of Early Mortality in Patients with Critical Limb Ischemia
Authors: Atsushi Tosaka, Yoshimitsu Soga, Osamu Iida, Keisuke Hirano, Kenji Suzuki, Taketsugu Tsuchiya, Daizo Kawasaki, Yusuke Miyashita, Masakiyo Nobuyoshi
Journal: Circulation (2011)
Abstract 13387: Prognostic Value of a Novel Circulating Serum Galectin-3 Binding Protein for the Development of a Transplant Vasculopathy After Heart Transplantation
Authors: Susanne Wangler, Thomas J Dengler, Andreas Doesch, Hugo Katus, Christian Erbel
Journal: Circulation (2011)

Background_ Heart transplantation is a treatment for end stage heart failure. But several complications such as acute rejection, graft failure, transplant vasculopathy (TVP) and cancer still limits the survival after heart transplantation. Galectin-3 binding protein (Gal-3BP) (human s90K/Mac-2BP) seem to have pro- as well as anti-inflammatory effects in various immune diseases. Thus, we investigated whether Gal-3BP represents an adequate marker for fatal complications after heart transplantation. Methods_ The study investigated the role of the immune modulator Gal-3BP by using an assay to determine the concentration of Galectin-3BP serum levels from 100 cardiac allograft recipients 6 weeks and then yearly up to five years after transplantation. Of each patient clinical data, medication and blood parameter were collected. TVP were diagnosed by coronary angiography. Results_ The study demonstrated that patients developing a TVP within five years after transplantation had significantly higher Gal-3BP serum l...
Investigations and actions taken during 2011 due to the first finding of Echinococcus multilocularis in Sweden
Authors: H Wahlström, A Lindberg, J Lindh, A Wallensten, R Lindqvist, L Plym-Forshell, E Osterman Lind, E O Ågren, S Widgren, U Carlsson, D Christensson, M Cedersmyg, E Lindström, G E Olsson, B Hörnfeldt, A Barragan, C Davelid, M Hjertqvist, M Elvander
Journal: Eurosurveillance (2012)

Echinococcus multilocularis is a parasite that can cause alveolar echinococcosis disease. After the first positive finding of E. multilocularis in Sweden in 2011, a consulting group with representatives from relevant authorities was summoned. In this group, all relevant information was shared, strategies for information dissemination and any actions to be taken due to the finding of E. multilocularis were discussed and decided. The present paper describes the actions taken during 2011 and the results thereof, including surveillance in animals, risk assessment for humans to become infected and recommendations given to the public. Further discussion about whether the parasite was introduced, and if so, how, as well as possible future development of the infection in animals and humans in Sweden and future actions are included.
Abstract 485: Follistatin-Like 1 is a Novel Secreted Muscle Protein that Confers Cardiovascular Protection
Authors: Noriyuki Ouchi, Yuichi Oshima, Kenneth Walsh
Journal: Circulation (2008)

Increasing evidence indicates that skeletal muscle secretes factors, referred to as myokines, that affect the behavior of neighboring or remote organs. Myogenic Akt signaling confers vascular protection during normal tissue growth. We focused on the identification of novel factors secreted from Akt1-activated skeletal muscle that have protective effects on the cardiovascular systems through paracrine mechanisms. Transgenic Akt1 overexpression in skeletal muscle led to myofiber growth that was coupled to an increase in muscle capillary density. Follistatin-like 1 (Fstl1) was selected as a potential myokine after a screening of upregulated transcripts in skeletal muscle of inducible Akt1 transgenic mice by microarray analysis. Myogenic Akt activation led to an induction of Fstl1 by muscle and increased circulating levels of Fstl1. Ischemic hindlimb surgery also induced Fstl1 expression by muscle and increased Fstl1 levels in serum. Intramuscular administration of an adenoviral vector expressing Fstl1 (Ad-Fstl1) accelerated flow recovery and increased capillary density in the ischemic hindlimbs of wild-type mice. These stimulatory effects were dependent on the upregulation of Akt-endothelial nitric oxide synthase (eNOS) signaling axes within endothelial cells. In cultured human umbilical vein endothelium cells, Ad-Fstl1 stimulated migration and differentiation into network structures, and inhibited apoptosis under conditions of serum deprivation. The pro-angiogenic actions of Fstl1 were mediated through its ability to activate Akt-eNOS signaling pathways. Furthermore, Ad-Fstl1 protected neonatal rat ventricular myocytes from hypoxia/reoxygenation-induced apoptosis and this protective effect was dependent on Akt activation. The intravenous administration of Ad-Fstl1 to wild-type mice resulted in a marked reduction in myocardial infarct size following ischemia-reperfusion injury that was accompanied by a significant reduction in apoptosis in the heart. These data indicate that Fstl1 is a novel Akt1-regulated myokine that can function to promote the new blood vessel growth in response to ischemia and protect against myocardial ischemia-reperfusion injury through its ability to activate Akt signaling in remote tissues.
The CSF3R T618I Mutation Found In Chronic Neutrophilic Leukemia Removes An O-Linked Glycosylation Site and Increases Receptor Dimerization
Authors: Julia E. Maxson, Jason Gotlib, Daniel A. Pollyea, Angela G. Fleischman, Anupriya Agarwal, Samuel B. Luty, Melissa Abel, Christopher A. Eide, Daniel Bottomly, Beth Wilmot, Shannon K. McWeeney, Cristina E. Tognon, Robert H. Collins, J. Blake Pond, Basem Goueli, Stephen T. Oh, Michael W. Deininger, Bill H. Chang, Marc M. Loriaux, Brian J. Druker, Jeffrey W. Tyner
Journal: Blood (2013)
Abstract 15388: Living with a Congenital Heart Disease: Quality of Life, Psychosocial Adjustment, Psychiatric Morbidity and School Performance May be Affected, but Social Support Plays an Important Role in promoting Resilience
Authors: Maria Emilia G Areias, Flávio Teixeira, Rosália Coelho, Isabela Freitas, Marta Castro, Sofia Sarmento, Cidália Proença, Ana Margarida Silva, Daniela Vieira, Cláudia Vaz, Cláudia Moura, Victor Viana, José Carlos Areias
Journal: Circulation (2011)

Introduction: Good care of congenital heart disease (CHD) allows patients to survive until a later adulthood, facing challenges for adjustment throughout life. Hypothesis: Quality of Life (QOL) and...
Abstract 2501: Incidence and Predictors of Angiographic Stent Thrombosis in Patients Treated With Drug-Eluting Stent Implantation for ST Segment Elevation Myocardial Infarction
Authors: Georgios Sianos, Michail I Papafaklis, Joost Daemen, Sophia Vaina, Carlos A van Mieghem, Ron T van Domburg, Lampros K Michalis, Patrick W Serruys
Journal: Circulation (2006)
血管平滑筋細胞(VSMC)におけるアンギオテンシンII(AII)およびC型ナトリウム利尿ペプチド(CNP)による成長停止特異的ホメオボックス(Gax)遺伝子発現の対照遺伝子調節
Authors: Yamashita J, Itoh H, Ogawa Y, Tamura N, Takaya K, Igaki T, Doi K, Chun Th, Inoue M, Masatsugu K, Yoshimasa T, Nakao K
Journal: Circulation (1996)
Abstract 216: The Cerebral Blood Flow Threshold for Membrane Repolarization is 3 Times Higher Than That for Membrane Depolarization and is Lowered by Intraischemic Hypothermia
Authors: Ryoichi Mizoue, Yoshimasa Takeda, Sachiko Sato, Ken Takata, Hiroshi Morimatsu
Journal: Circulation (2013)

Introduction: It has been reported that cerebral blood flow (CBF) supplied by chest compression (20-40% of control levels) exceeds the CBF threshold for membrane depolarization (20%). However, the CBF threshold for membrane repolarization has not been studied. It is unknown whether chest compression can restore membrane potential. In the present study, we compared the CBF threshold for depolarization with that for repolarization. In addition, the effects of brain hypothermia on the repolarization threshold were evaluated. Methods: Rats (10 in each group) were anesthetized with isoflurane. CBF was measured by placing a laser-Doppler flow probe placed adjacent to a direct current (DC) potential electrode in the parietal cerebral cortex. Following bilateral occlusion of common carotid artery, CBF was continuously decreased by exsanguination at a speed of 5% of the baseline level every 2 min until a sudden negative DC shift was observed. After 5 or 10 min of ischemic depolarization, the CBF was restored at the same rate by returning blood until a positive DC shift was observed. In the hypothermia groups, brain temperature was decreased to 31°C by initiating nasopharyngeal cooling after depolarization. Result: The threshold for repolarization (46.5 ± 12%) was significantly higher than that for depolarization (19.2 ± 5%, p &lt; 0.001) after 5 min of depolarization time, and further increased to 61.5 ± 14% (p &lt; 0.05) after 10 min of depolarization time. Brain hypothermia significantly decreased the threshold for repolarization (5 min of ischemic depolarization: 33.8 ± 10%, p &lt; 0.05 compared with normal temperature, 10 min: 36.6 ± 6%, p &lt; 0.05). Conclusion: Thresholds for repolarization were significantly higher than those for depolarization and are likely to exceed the levels supplied by chest compression. Induced brain hypothermia during ischemia lowered CBF thresholds for repolarization and may help protect the brain during CPR.
Abstract 2002: Dual Mechanism of Blood Flow Augmentation to the Brain using an Impedance Threshold Device in a Pediatric Model of Cardiac Arrest
Authors: Carly Alexander, Demetris Yannopoulos, Tom Aufderheide, Scott McKnite, Tim Matsuura, Anja Metzger, Keith Lurie
Journal: Circulation (2007)

Background: During cardiac arrest use of an impedance threshold device (ITD) increases circulation and the chances for survival. The ITD has not been systematically evaluated during conventional CPR in a pediatric animal model. We hypothesized that the ITD increases blood flow to the brain by lowering intrathoracic pressure during the CPR decompression phase thus enhancing venous return to the right heart and forward flow with the subsequent compression and maintaining or lowering diastolic intracranial pressure (ICP) thus reducing resistance to forward flow. In this manner ITD use was hypothesized to mimic the ‘gasping reflex’ during CPR. Methods: In the first study 9 female propofol anesthetized piglets (10–12 kg) were subjected to 6 min of untreated ventricular fibrillation, 6 min of conventional CPR (ventilation rate 10 bpm), then 6 min of CPR with an active ITD (resistance of −10 cm H20). A second study was similar except that a sham ITD was used in 8 piglets. Results: After 2 min of active ITD treatment, decompression phase airway pressures (surrogate for intrathoracic pressure) (mmHg) decreased from −0.5 ± 0.2 to −2.6 ± 0.5 (mean ± SEM, p &lt; 0.001) and common carotid blood flow (mL/min) increased by 65% (59.2 ± 16.7 to 91.1± 27.9, p = 0.02). In the sham group, airway pressures were unchanged and carotid blood flow decreased from 39 ± 2.5 to 38.8 ± 4.3 (p = 0.47). ICP decreased more rapidly in time and to a greater degree in 6/9 piglets when comparing ITD use to measurements preceding its application, contributing to an increase in cerebral perfusion (CePP) (mmHg) in 5/9 active ITD piglets, while in the sham group, CePPs remained the same or decreased in 8/8 piglets (p = 0.03). Coronary perfusion pressures (CPP) (mmHg) increased in 5/9 piglets after 2 min of the active ITD and remained the same or decreased in 8/8 piglets treated with the sham device (p = 0.03). Return of spontaneous circulation was achieved with a single shock in 4/9 active ITD piglets and 1/8 sham ITD piglets (p = 0.29). Conclusions: Use of an active ITD during CPR in piglets significantly increased carotid blood flow and CPPs. The ITD also lowered ICP during the decompression phase, similar to the mechanism of the ‘last gasp’, thereby reducing resistance to forward blood flow to the brain.
Abstract 1831: Phosphodiesterase-5 Inhibition Prevents Cardiac Hypertrophy, Independently of the Calcineurin Pathway
Authors: Steven Hsu, Takahiro Nagayama, Norimichi Koitabashi, Liye Zhou, Manling Zhang, Djahida Bedja, Kathleen Gabrielson, David A Kass, Eiki Takimoto
Journal: Circulation (2008)

Cyclic GMP and its downstream kinase protein kinase G (PKG) negatively regulate cardiac hypertrophy. To date the only documented target of this cascade is the serine-threonine phosphatase calcineurin (Cn), whose activation is central to the development of pathologic cardiac hypertrophy. Recently, we reported that phosphodiesterase 5 (PDE5) inhibition (sildenafil, SIL) activates myocardial PKG and prevents pressure-overload induced hypertrophy by suppressing multiple cascades including Cn. To test the centrality of Cn signaling to the in vivo anti-hypertrophic effects of SIL, we subjected mice deficient in the Cn-A β subunit (CnA β −/− ) to severe trans-aortic constriction (TAC) with or without SIL (100mg/kg/day, p.o.) for 3-wks. TAC induced less hypertrophy that was more concentric in CnA β −/− vs WT-controls (50% vs 100% increase in heart mass/tibia length, p&lt;0.03). SIL completely blocked the hypertrophic response and fully normalized fetal gene re-expression (e.g ANP, BNP and β MHC) in CnA β −/− TAC hearts, while it inhibited LVH by 60% and suppressed ANP and β MHC in WT-TAC hearts. SIL improved cardiac systolic and diastolic function (pressure-volume analysis) in CnA β −/− TAC hearts much as in WT-TAC hearts. In CnA β −/− TAC hearts, phosphorylated calcium calmodulin kinase II (CaMK II) increased 10-fold versus only a 2-fold rise in WT-TAC, whereas Akt and glycogen synthase kinase 3 β (GSK3 β ) activation were comparable between groups. Extracellular response kinase (ERK) 1/2 was activated with TAC in WT hearts only. Importantly, SIL stimulated myocardial PKG and markedly inhibited the activation of CaMKII, Akt and GSK3 β similarly in both groups exposed to TAC. Thus, Cn is not required for the anti-hypertrophic effects of SIL. Though TAC-induced hypertrophy is less in CnA β −/− mice, SIL remains effective in suppressing the residual response by targeting alternative cascades such as CaMK II. These findings suggest that SIL acts either on multiple pathways concurrently, or at a node proximal to these pathways likely at or near the sarcolemmal membrane.
Abstract 1933: Correlates of Bleeding After a 600 mg Loading Dose of Clopidogrel, With and Without Abciximab: A Pooled Analysis of 4 ISAR Randomized Trials.
Authors: Arun Kalyanasundaram, Peter B Berger, Gjin Ndrepepa, Julinda Mehilli, Stefanie Schulz, Albert Schömig, Adnan Kastrati
Journal: Circulation (2007)

Background . Bleeding complications during PCI have been shown to be related to mortality. Little is known about the frequency and correlates of bleeding in patients (pts) undergoing PCI after a 600 mg loading dose of clopidogrel. Methods . We performed a pooled analysis of the ISAR-REACT, ISAR-SWEET, ISAR-SMART 2, and ISAR-REACT 2 trials in which 5,384 pts undergoing PCI ≥2 hours after a 600 mg loading dose of clopidogrel were randomized to receive abciximab or placebo. Bleeding was assessed using the Thombolysis in Myocardial Infarction (TIMI) scale. Multiple logistic regression model was used to identify independent correlates of 30-day bleeding; 22 standard clinical and procedural variables were analyzed. Pts receiving abciximab received a single bolus of 70 units/kg of heparin; those who did not received a single bolus of 140 units/kg. Results . Following the PCI procedure, 215 pts (4.0%) bled; bleeding was major in 59 pts (1.1%) and minor in 156 (2.9%). Pts who bled were older, more likely to be female, have a lower body mass index (BMI), have an acute coronary syndrome and multivessel disease, a lower left ventricular ejection fraction and slightly shorter lesions than pts without bleeding. Multiple logistic regression model revealed that female sex (odds ratio 2.06 [95% CI 1.52–2.79], p&lt;0.001), lower BMI (per decrease of 5 kg/m 2 ) (1.54 [1.27–1.89], p&lt;0.001), administration of abciximab (1.54 [1.15–2.04], p=0.003), age (per 10-year increase) (1.20 [1.03–1.41], p=0.02), and diameter stenosis (10% increase) (1.13 [1.03–1.24], p=0.008) were all independently associated with bleeding. Conclusion . Bleeding occurred in 4.0% of 5,384 pts who received a 600 mg loading dose of clopidogrel &gt;2 hours, half of whom received abciximab, before a PCI in 4 ISAR trials. Abciximab was the only modifiable variable associated with bleeding. Abciximab should be utilized cautiously in women, older patients and those with lower BMI.
Semantic organization of hallucinated "voices" in schizophrenia
Authors: R E Hoffman, E Oates, R J Hafner, H H Hustig, T H McGlashan
Journal: American Journal of Psychiatry (1994)

The authors found that the different hallucinated "voices" of four schizophrenic subjects reported over 1-3 weeks expressed semantic content that was at least as persistent as clauses sampled from single 5-7-minute conversational discourses of four comparison speakers. The high degree of semantic recurrence of voices from one day to the next may contribute to the mistaken belief that these experiences derive from a particular nonself agent or speaker.
Abstract 16888: Computational Simulations of Coronary Artery Flow in Supravalvular Aortic Stenosis
Authors: Ryo Inuzuka, Fuyou Liang, Koichi Sughimoto, Hao Liu, Hideaki Senzaki
Journal: Circulation (2012)

Introduction: Supravalvular aortic stenosis (SVAS) and aortic coarctation (CoA) are sources of ventricular afterload, which can lead to a mismatch between coronary artery flow (CF) and cardiac oxyg...
Abstract 4127: Dual Chamber ICD Selection is Associated with Racial and Socioeconomic Disparities and Increased Complication Rates Among Patients Enrolled in the NCDR ICD Registry
Authors: Thomas A Dewland, Cara N Pellegrini, Yongfei Wang, Gregory M Marcus, Paul D Varosy
Journal: Circulation (2008)

Background: Dual chamber implantable cardioverter-defibrillators (ICDs) offer potential advantages over single chamber devices. Definitive evidence demonstrating improved outcomes with dual chamber ICDs is lacking, however, and the choice of such devices remains controversial. The prevalence, predictors, and procedural complication rates of single versus dual chamber devices in patient populations not enrolled in randomized trials are unknown. Methods and Results: Between January 2006 and December 2007, the NCDR ICD Registry recorded 104,049 first-time implantations of single or dual chamber ICDs. Dual chamber devices were implanted in 64,489 patients (62%). After adjusting for potential confounding factors and clustering on patient center using hierarchical logistic regression models, characteristics associated with lower odds of dual chamber ICD implantation included black race (odds ratio (OR), 0.89; 95% confidence interval (CI), 0.85 – 0.93), Medicaid insurance (OR, 0.88; CI, 0.82 – 0.94), diabetes (OR, 0.94; CI, 0.91 – 0.97), and end-stage renal disease (OR, 0.82; CI, 0.76 – 0.89). Complications were more frequent with dual chamber device implantation, including cardiac arrest (0.31% vs. 0.23%, P = 0.01), hematoma (0.92% vs. 0.71%, P &lt; 0.001), pneumothorax (0.53% vs. 0.36%, P &lt; 0.001), pericardial tamponade (0.09% vs. 0.05%, P = 0.01), lead dislodgement (0.88% vs. 0.50%, P &lt; 0.001), and any complication (3.2% vs. 2.1%, P &lt; 0.001). The increased risk of complications associated with dual chamber ICD selection persisted after adjusting for patient demographic characteristics, medical comorbidities, and ICD indication (OR, 1.40; CI, 1.28 – 1.52; P &lt; 0.001). Conclusions: While dual chamber ICD selection is more common than single chamber implantation among patients enrolled in the NCDR ICD Registry, both blacks and patients insured with Medicaid are less likely to receive dual chamber devices. Further investigation is needed to determine whether the benefits of dual chamber ICD therapy outweigh the greater risk of peri-procedural complications.
Abstract 16299: Long-Term Follow Up of the Viability Guided Angioplasty after Acute Myocardial Infarction (VIAMI) Trial
Authors: Ramon B van Loon, Gerrit Veen, Leo H Baur, Otto Kamp, Jean G Bronzwaer, Jos W Twisk, Freek W Verheugd, Albert C van Rossum
Journal: Circulation (2012)
Abstract 17397: Discovery and Validation of Novel Genes Predicting Cardiac Remodeling on {beta}-blockade
Authors: Brian D Lowes, Ronald Zolty, Edward M Gilbert, Alastair D Robertson, Michael R Bristow
Journal: Circulation (2010)

Background: Gene arrays allow for genome wide transcriptional analysis. Gene array studies are limited by false discovery (FD) due to multiple hypothesis testing. Our goal was to identify novel gen...