Delayed-Type Hypersensitivity and AIDS
Authors: Raphael B. Stricker, Blaine F. Elswood
Journal: Annals of Internal Medicine (1994)

Letters15 February 1994Delayed-Type Hypersensitivity and AIDSRaphael B. Stricker, MD and Blaine F. Elswood, MARaphael B. Stricker, MDCalifornia Pacific Medical Center; San Francisco, DA 94120University of California; San Francisco, CA 94143Search for more papers by this author and Blaine F. Elswood, MACalifornia Pacific Medical Center; San Francisco, DA 94120University of California; San Francisco, CA 94143Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-120-4-199402150-00017 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:The article by Blatt and colleagues [1] shows the prognostic significance of cutaneous delayed-type hypersensitivity testing in patients infected with human immunodeficiency virus (HIV). The excellent editorial by Kornbluth and McCutchan [2] discusses the Th1/Th2 switch that plays an important role in the loss of delayed-type hypersensitivity in HIV. Both articles focus on delayed-type hypersensitivity as a diagnostic tool in patients with the acquired immunodeficiency syndrome (AIDS).The concept of using the cutaneous delayed-type hypersensitivity response as a therapeutic tool in patients with HIV has been discussed previously [3]. Topical dinitrochlorobenzene, a potent stimulant of the delayed-type ...References1. Blatt SP, Hendrix CW, Butzin CA, Freeman TM, Ward WW, Hensley RE, et al. Delayed-type hypersensitivity skin testing predicts progression to AIDS in HIV-infected patients. Ann Intern Med. 1993; 119: 177-84. Google Scholar2. Kornbluth RS, McCutchan JA. Skin test responses as predictors of tuberculous infection and of progression in HIV-infected patients. Ann Intern Med. 1993; 119:241-3. Google Scholar3. Stricker RB, Elswood BF, Abrams DI. Dendritic cells and dinitrochlorobenzene (DNCB): a new treatment approach to AIDS. Immunol Lett. 1991; 29:191-6. Google Scholar4. Stricker RB, Elswood BF. Topical dinitrochlorobenzene in HIV disease. J Am Acad Dermatol. 1993; 28:796-7. Google Scholar5. Stricker RB, Zhu YS, Elswood BF, Dumlao C, Van Elk J, Berger TG, et al. Pilot study of topical dinitrochlorobenzene (DNCB) in human immunodeficiency virus infection. Immunol Lett. 1993; 36:1-6. Google Scholar6. Cumberbatch M, Gould SJ, Peters SW, Basketter DA, Dearman RJ, Kimber I. Langerhans cells, antigen presentation, and the diversity of responses to chemical allergens. J Invest Dermatol. 1992; 99:107S- 8S. Google Scholar Author, Article, and Disclosure InformationAffiliations: California Pacific Medical Center; San Francisco, DA 94120University of California; San Francisco, CA 94143 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByImproved results of delayed-type hypersensitivity skin testing in HIV-infected patients treated with topical dinitrochlorobenzeneAIDS Aware 15 February 1994Volume 120, Issue 4Page: 343-344KeywordsAIDSAnergyAntigensHIVHIV infectionsHypersensitivityImmune responseImmune systemPatientsPilot studies Issue Published: 15 February 1994 CopyrightCopyright © 1994 by American College of Physicians. All Rights Reserved.PDF DownloadLoading ...