THE TREATMENT OF SUBACUTE BACTERIAL ENDOCARDITIS WITH PENICILLIN
Authors: James E. Paullin, Christopher John Mcloughlin
Journal: Annals of Internal Medicine (1945)

Article1 April 1945THE TREATMENT OF SUBACUTE BACTERIAL ENDOCARDITIS WITH PENICILLINJAMES E. PAULLIN, M.D., F.A.C.P., CHRISTOPHER JOHN MCLOUGHLIN, M.D.JAMES E. PAULLIN, M.D., F.A.C.P.Search for more papers by this author, CHRISTOPHER JOHN MCLOUGHLIN, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-22-4-475 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe results of treatment of subacute bacterial endocarditis have been as disappointing and unavailing as of any disease known to medicine. The disease is not uncommon and is found most frequently in localities where rheumatic heart disease is common. Until the present time treatment has been discouraging; attempts to immunize the patient by vaccines, serums, and non-specific shock therapies were very disappointing; in fact these methods seemed to shorten the patient's life rather than prolong it. Intravenous injections of mercurochrome, acriflavine, and gentian violet produced no results, although some of them were encouraging, particularly the use of merthiolate which seemed...Bibliography1. LIBMANFRIEDBERG ECK: Subacute bacterial endocarditis, Cyclopedia of Med., 1939, F. A. Davis, Philadelphia, Vol. 3, 660. Google Scholar2. LICHTMAN SS: Treatment of subacute bacterial endocarditis, current results, Ann. Int. Med., 1943, xix, 787-794. Google Scholar3. GALBREATHHULL WRE: Sulfonamide therapy of bacterial endocarditis: results in 42 cases, Ann. Int. Med. 1942, xviii, 201-203. Google Scholar4. BUNN WH: Subacute bacterial endocarditis; inherent difficulties in prognosis, Jr. Am. Med. Assoc., 1944, cxxv, 1023-1025. CrossrefGoogle Scholar5. KRUSENBENNETT FHRL: Unsuccessful treatment of subacute bacterial endocarditis with combined fever and sulfanilamide therapy, Proc. Staff Meet. Mayo Clin., 1940, xv, 328-332; 1940, xv, 352. Google Scholar6. SOLOMON H: Subacute bacterial endocarditis, treatment with sulfapyridine and intravenous injections of typhoparatyphoid vaccine, New York State Jr. Med., 1941, xli, 45. Google Scholar7. HERRELLNICHOLSHEILMAN WEDRDH: Penicillin, Jr. Am. Med. Assoc., 1944, cxxv, 1003-1011. CrossrefGoogle Scholar8. EVANS AL: Personal communication. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Atlanta, Georgia*Received for publication January 29, 1945.From the Medical Department of the Emory University Medical College. Nextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byTHERAPY OF SUBACUTE ENTEROCOCCUS (STREPTOCOCCUS FECALIS) ENDOCARDITIS*LEO LOEWE, M.D., SAMUEL CANDEL, M.D., F.A.C.P., HAROLD B. EIBER, M.D.THE TREATMENT OF BACTERIAL ENDOCARDITIS*EDWARD S. ORGAIN, M.D., F.A.C.P., CHARLES K. DONEGAN, M.D.General Practice ReviewPENICILLIN TREATMENT OF SUBACUTE BACTERIAL ENDOCARDITISThe treatment of subacute bacterial endocarditis with antibiotics 1 April 1945Volume 22, Issue 4Page: 475-484KeywordsBacterial diseasesCardiovascular therapyEndocarditisHeart diseasesIntravenous injectionsPenicillinShockVaccines Issue Published: 1 April 1945 Copyright & PermissionsCopyright, 1945, by The American College of PhysiciansPDF downloadLoading ...