tbuckley/cabot-search huggingface dataset:
India plans new legislation to prevent sex selection
Authors: G. Mudur
Journal: BMJ (2002)

The Indian health ministry has drafted legislation to regulate reproduction technologies in a fresh attempt to curb the widespread preference for male children in India.

The legislation will ban the use of preimplantation genetic diagnosis and other reproductive technologies for sex selection through amendments to an existing law that prohibits fetal sex determination. The amended legislation will allow genetic diagnosis for detecting medical conditions, however.

India outlawed fetal sex determination for sex selection eight years ago, but prenatal sex determination through ultrasonography continues. The practice, stemming from traditional prejudices against girls in Indian society, leads to …
Should Nonalcoholic Fatty Liver Disease Be Included in the Definition of Metabolic Syndrome? A Cross-Sectional Comparison With Adult Treatment Panel III Criteria in Nonobese Nondiabetic Subjects: Response to Sookoian et al.
Authors: Giovanni Musso, Roberto Gambino, Simona Bo, Maurizio Cassader
Journal: Diabetes Care (2008)

The findings of Sookoian et al. (1) expand our recent research (2) and further suggest that the liver, the vessel wall, and adipose tissue share common inflammatory pathways. Intracellular adhesion molecule-1 (ICAM-1) is a transmembrane adhesion molecule involved in leukocyte migration to inflammatory …
Do Not Order "Clinical Thyroidology"
Authors: JOEL I. HAMBURGER
Journal: Annals of Internal Medicine (1977)

Letters and Corrections1 August 1977Do Not Order "Clinical Thyroidology"JOEL I. HAMBURGER, M.D.JOEL I. HAMBURGER, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-87-2-249_2 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: I share your reviewer's reservations as to the continuing value of Clinical Thyroidology (reviewed in Ann Intern Med 86:675, 1977). In fact, I have been refusing orders for 8 months. Although its therapeutic concepts remain valid, its diagnostic methods are no longer suitable because of several recent developments.1. Thyrotrophin-releasing hormone testing (at last available) makes T3 suppression tests virtually obsolete and reduces the needs for thyroid-stimulating hormone stimulation tests. Thus my diagnostic flowsheets required complete revision.2. Recent interest in percutaneous cytologic and histologic evaluation of thyroid nodules requires attention.3. The change from rectilinear to... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: JOEL I. HAMBURGER, M.D.Affiliations: Northland Thyroid Laboratory 20905 Greenfield Street Southfield, MI 48075 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 August 1977Volume 87, Issue 2Page: 249-249KeywordsThyroidThyroid-stimulating hormoneTriiodothyronine ePublished: 1 December 2008 Issue Published: 1 August 1977 PDF downloadLoading ...
A PLEA FOR GREATER UNIFORMITY OF STRENGTH AND EXACTNESS IN OUR MEDICAL ARMAMENTARIUM.
Authors: C. F. WAHRER
Journal: JAMA (1902)

The subject of my paper may not be new to anyone here, and, like the longing for immortality and the fabled Fountain of Youth, may be somewhat utopian in its nature, yet we must not forget that keeping eternally at it has often been followed by good results. We certainly can not admire Shakespeare for the originality of his subject-matter, for everything he wrote was either old history or romance before he was born, but the manner in which he put it, and the way he said things and made his hearers and readers feel it, there is where Shakespeare is great. So if I can impress you with what I have to say in such a manner that you can all feel it, and so it will do good, my ambition will be satisfied. We are all aware that in the good old days we guessed at many things,
A Simple Index to Predict Adverse Clinical Outcome Associated with Acute Myocardial Infarction in Primary PCI Era
Authors: Mustafa Tarık Ağaç, Suret Ağaç, Levent Korkmaz, Turhan Turan, Hüseyin Bektaş, Ali Rıza Akyüz, Mustafa Çetin, Hakan Erkan, Bülent Vatan, Şükrü Çelik
Journal: Journal of the American College of Cardiology (2013)
Racial Disparities in Health Status
Authors: Joan O'Connell, Rong Yi, Charlton Wilson, Spero M. Manson, Kelly J. Acton
Journal: Diabetes Care (2010)

OBJECTIVE American Indians and Alaska Natives are 2.3 times more likely to have diabetes than are individuals in the U.S. general population. The objective of this study was to compare morbidity among American Indian and U.S. adults with diabetes. RESEARCH DESIGN AND METHODS We extracted demographic and health service utilization data for an adult American Indian population aged 18–64 years (n = 30,121) served by the Phoenix Service Unit from the Indian Health Service clinical reporting system. Similar data for a U.S. population (n = 1,500,002) with commercial health insurance, matched by age and sex to the American Indian population, were drawn from the MartketScan Research Database. We used Diagnostic Cost Groups to identify medical conditions for which each individual was treated and to assign a risk score to quantify his or her morbidity burden. We compared the prevalence of comorbidities and morbidity burden of American Indian and U.S. adults with diabetes. RESULTS American Indians with diabetes had significantly higher rates of hypertension, cerebrovascular disease, renal failure, lower-extremity amputations, and liver disease than commercially insured U.S. adults with diabetes (P &amp;lt; 0.05). The American Indian prevalence rates were 61.2, 6.9, 3.9, 1.8, and 7.1%, respectively. The morbidity burden among the American Indian with diabetes exceeded that of the insured U.S. adults with diabetes by 50%. CONCLUSIONS The morbidity burden associated with diabetes among American Indians seen at the Phoenix Service Unit far exceeded that of commercially insured U.S. adults. These findings point to the urgency of enhancing diabetes prevention and treatment services for American Indians/Alaska Natives to reduce diabetes-related disparities.
Renal Tubular Obstruction by Mucoproteins from Adenocarcinoma of Pancreas
Authors: J. R. Hobbs, D. J. Evans, O. M. Wrong
Journal: BMJ (1974)

We report a case in which mucoproteins from an adenocarcinoma of the pancreas, released into the ascitic fluid and serum, were filtered through the renal glomeruli to form very viscous casts which obstructed the renal collecting tubules and caused the patient9s death from oliguria.
Mature Results from a Phase II Trial of Postoperative Concurrent Chemoradiotherapy for Poor Prognosis Cancer of the Esophagus and Gastroesophageal Junction
Authors: David J. Adelstein, Thomas W. Rice, Lisa A. Rybicki, Jerrold P. Saxton, Gregory M.M. Videtic, Sudish C. Murthy, David P. Mason, Cristina P. Rodriguez, Denise I. Ives
Journal: Journal of Thoracic Oncology (2009)
Sunscreen and Prevention of Skin Aging
Authors: Maria Celia B. Hughes, Gail M. Williams, Peter Baker, Adèle C. Green
Journal: Annals of Internal Medicine (2013)

Chinese translation Background: Sunscreen use and dietary antioxidants are advocated as preventives of skin aging, but supporting evidence is lacking. Objective: To determine whether regular use of sunscreen compared with discretionary use or β-carotene supplements compared with placebo retard skin aging, measured by degree of photoaging. Design: Randomized, controlled, community-based intervention. (Australian New Zealand Clinical Trials Registry: ACTRN12610000086066). Setting: Nambour, Australia (latitude 26° S). Patients: 903 adults younger than 55 years out of 1621 adults randomly selected from a community register. Intervention: Random assignment into 4 groups: daily use of broad-spectrum sunscreen and 30 mg of β-carotene, daily use of sunscreen and placebo, discretionary use of sunscreen and 30 mg of β-carotene, and discretionary use of sunscreen and placebo. Measurements: Change in microtopography between 1992 and 1996 in the sunscreen and β-carotene groups compared with controls, graded by assessors blinded to treatment allocation. Results: The daily sunscreen group showed no detectable increase in skin aging after 4.5 years. Skin aging from baseline to the end of the trial was 24% less in the daily sunscreen group than in the discretionary sunscreen group (relative odds, 0.76 [95% CI, 0.59 to 0.98]). β-Carotene supplementation had no overall effect on skin aging, although contrasting associations were seen in subgroups with different severity of aging at baseline. Limitation: Some outcome data were missing, and power to detect moderate treatment effects was modest. Conclusion: Regular sunscreen use retards skin aging in healthy, middle-aged men and women. No overall effect of β-carotene on skin aging was identified, and further study is required to definitively exclude potential benefit or potential harm. Primary Funding Source: National Health and Medical Research Council of Australia.
RELATION BETWEEN ESCHERICHIA COLI R(ROUGH)-FORMS IN GUT, LIPID A IN LIVER, AND PRIMARY BILIARY CIRRHOSIS
Authors: Uwe Hopf, Roman Stemerowicz, Arne Rodloff, Chris Galanos, Bernd Möller, Hartmut Lobeck, Marina Freudenberg, Dieter Huhn
Journal: The Lancet (1989)
CX-4945, a selective inhibitor of casein kinase-2 (CK2), exhibits anti-tumor activity in hematologic malignancies including enhanced activity in chronic lymphocytic leukemia when combined with fludarabine and inhibitors of the B-cell receptor pathway
Authors: R C Prins, R T Burke, J W Tyner, B J Druker, M M Loriaux, S E Spurgeon
Journal: Leukemia (2013)
Deficiency of the second complement component association with the HLA haplotype A10, B18 in a normal population.
Authors: R I Rynes, A F Britten, R J Pickering
Journal: Annals of the Rheumatic Diseases (1982)

Serum C2 activity was measured in 135 individuals drawn from a panel of 418 tissue-typed blood donors. The study group included all donors with HLA antigens A10 and B18. Heterozygote C2 deficiency (C2Dhet) was defined by reference to the range of C2 activity in previously studied obligate heterozygotes. Five donors were C2Dhet. Family studies confirmed that C2Dhet was associated in all instance with an A10, B18 haplotype. The minimum frequency for C2Dhet was 1.2% in the panel of 418 donors and 62.5% in those donors with an A10, B18 haplotype.
Periodontal disease and hypertriglyceridemia in Japanese subjects: potential association with enhanced lipolysis
Authors: Hideo Nakarai, Akiko Yamashita, Mikimasa Takagi, Masataka Adachi, Masaharu Sugiyama, Haruhiko Noda, Masafumi Katano, Ryuji Yamakawa, Keiji Nakayama, Hitomi Takumiya, Yoshikatsu Nakai, Ataru Taniguchi, Fusanori Nishimura
Journal: Metabolism (2010)
A New Look for CVR in 2008
Authors: H. M. Piper, D. Garcia-Dorado, E. A. Martinson
Journal: Cardiovascular Research (2007)

This means that while reading a CVR article online, you can link to other relevant papers within the realm of cardiovascular sciences through the reference list, many of them 'toll-free' owing to their being in the HighWire pool of journals.
963 Analysis of the HBVDNA integration in HBV-related hepatocellular carcinoma
Authors: Y MURAKAMI, K SAIGO, M MINAMI, C BRECHOT, P PATERLINIBRECHOT, T OKANOUE
Journal: Hepatology (2003)

To investigate the relation between hepatitis B virus(HBV) genotypes and the double mutation of A-to-T nucleotide(nt) 1762 and G-to-A nt 1764 in basic core promoter(BCP T1762/A1764) in patients of the Li nationality.Subjects were 125 HBV DNA positive patients that belong to the Li nationality on Hainan Island. HBV DNA genotype was determined by real time fluorimetry polymerase chain reaction. BCP T1762/A1764 mutation was performed using the direct sequencing method.The prevalence rates of genotype B, genotype C, genotype D, genotype C and D mixed infection(genotype C + D) and genotype B and D mixed infection (genotype B + C) were 31.20%, 53.60%, 12.00%, 2.40% and 0.80% respectively. Mutation frequencies in patients infected with HBV genotype C(58.21%) were significantly higher than in those infected with other genotypes (P < 0.01). The serum viral load of the patients with genotype C(5.74±1.21) was also higher than that of those with genotype B(P < 0.01).The major genotypes in the Li nationality were genotype C and genotype B. The infection of genotype D and mixed infection also occurred in the Li nationality. Genotype C HBV has a higher replication rate, and the different degrees of pathogenecity among HBV genotypes may be related to BCP T1762/A1764 mutation frequency.
Pharmaceutical Marketing and the New Social Media
Authors: Jeremy A. Greene, Aaron S. Kesselheim
Journal: New England Journal of Medicine (2010)

Facebook and Twitter, the largest social media Web sites, have more than 350 million users worldwide, and surveys indicate that 60% of Americans turn first to the Internet when seeking health-related information.1 It is therefore surprising that the pharmaceutical and medical-device industries have been slow to establish a social media presence. The drug industry allocated less than 4% of the more than $4 billion it spent on direct-to-consumer advertising to Internet outlets in 2008, and only a tiny fraction of that was for social networking sites.2 In the next year, however, the proportion may change substantially.Since the Pure Food . . .
Salmonella in Turtles Imported to Israel From Louisiana
Authors: Gideon Chassis
Journal: JAMA (1986)

<h3>To the Editor.—</h3> The article entitled "Turtle-Associated Salmonellosis in Puerto Rico"<sup>1</sup>led us to investigate the status of<i>Salmonella</i>in small green pet turtles,<i>Pseudemys scripta-elgans</i>in Israel. All of these turtles were legally imported into Israel and originated in Louisiana. Water (50 to 80 mL) from 32 aquariums containing these turtles was collected from pet shops and private households and examined for<i>Salmonella</i>at the Ministry of Health laboratories either in Beersheva or Jerusalem. All aquariums were sampled once. Of the 32, seven (22%) yielded<i>Salmonella</i>. One sample yielded two serotypes. All others yielded one serotype. There were six serotypes isolated, including<i>Salmonella poona</i>(three samples),<i>Salmonella arizona, Salmonella blockley, Salmonella java, Salmo-</i><i>nella schwarzengrund, and Salmonella thompson</i>(one sample each). As a result of the article, which renewed our interest in this hazard to public health, the importation of these turtles into Israel has been temporarily banned.
Polymorphisms in SPINK5 are not associated with asthma in a Dutch population
Authors: Hajo Jongepier, Gerard H. Koppelman, Ilja M. Nolte, Marcel Bruinenberg, Eugene R. Bleecker, Deborah A. Meyers, Gerard J. te Meerman, Dirkje S. Postma
Journal: Journal of Allergy and Clinical Immunology (2005)
CLINICAL IMPACT OF POST-OPERATIVE ANALGESIA IN PATIENTS UNDERGOING TRANSAPICAL TRANSCATHETER AORTIC VALVE IMPLANTATION
Authors: Ignacio J. Amat-Santos, Eric Dumont, Jacques Villeneuve, Daniel Doyle, Michel Rheault, Dominique Lavigne, Michael Mok, Marina Urena, Luis Nombela-Franco, Jose Luis Carrasco, M&eacute;lanie C&ocirc;t&eacute;, Philippe Pibarot, Robert DeLarochelli&egrave;re, Josep Rod&eacute;s-Cabau
Journal: Journal of the American College of Cardiology (2012)
FoxO1 expression in osteoblasts regulates glucose homeostasis through regulation of osteocalcin in mice
Authors: Marie-Therese Rached, Aruna Kode, Barbara C. Silva, Dae Young Jung, Susan Gray, Helena Ong, Ji-Hye Paik, Ronald A. DePinho, Jason K. Kim, Gerard Karsenty, Stavroula Kousteni
Journal: Journal of Clinical Investigation (2009)

Osteoblasts have recently been found to play a role in regulating glucose metabolism through secretion of osteocalcin. It is unknown, however, how this osteoblast function is regulated transcriptionally. As FoxO1 is a forkhead family transcription factor known to regulate several key aspects of glucose homeostasis, we investigated whether its expression in osteoblasts may contribute to its metabolic functions. Here we show that mice lacking Foxo1 only in osteoblasts had increased pancreatic β cell proliferation, insulin secretion, and insulin sensitivity. The ability of osteoblast-specific FoxO1 deficiency to affect metabolic homeostasis was due to increased osteocalcin expression and decreased expression of Esp, a gene that encodes a protein responsible for decreasing the bioactivity of osteocalcin. These results indicate that FoxO1 expression in osteoblasts contributes to FoxO1 control of glucose homeostasis and identify FoxO1 as a key modulator of the ability of the skeleton to function as an endocrine organ regulating glucose metabolism.
From targets to standards: but not just yet
Authors: Chris Ham
Journal: BMJ (2005)

The challenge will be for ministers not to interfere in a regulated service 

T he NHS in England marked the fourth anniversary of publication of the NHS Plan1 in July 2004 with the launch of the planning framework for the next three years and the standards that all organisations will be expected to achieve in delivering NHS care.2 The planning framework and standards mark a further stage in the reform of England's NHS and are important as an indication of the Labour government's thinking on priorities for the future and the methods that will be used to bring about change.

The planning framework sets out priorities in four areas: access to services, long term conditions, the health of the population, and the experience of patients or users. In each area national targets are identified for 2008 (and beyond in the case of the health of the population). These targets are based on the public service agreement negotiated between the Department of Health and the Treasury—with one exception, the aspiration to reduce infections caused by methicillin resistant Staphylococcus aureus (MRSA). The publication of a critical report by the National Audit Office on MRSA3 after release of the public service agreement explains the late addition of this target.

Three aspects of the …
Trichothiodystrophy: an electron-histochemical study of the hair shaft
Authors: C.L. GUMMER, R.P.R. DAWBER, V.H. PRICE
Journal: British Journal of Dermatology (1984)

We have used sensitive electron-histochemical methods to study the subtle ultrastructural variations of cystine incorporation into the hair shaft in trichothiodystrophy. We have shown a general reduction in the cystine (sulphur) content of both the cuticle and the cortex. Discontinuity, and in some cases, complete absence of the cuticular A-layer results in premature weathering of the cuticle and weakening of the hair shaft. The ultrastructural findings support the work of Gillespie & Marshall (1981) in demonstrating the absence or re-characterization of the high sulphur matrix proteins and show further evidence for the incorporation, and abnormal distribution and deposition of sulphur-rich proteins in the hair cortex and cuticle. We conclude that the similar yet different results obtained from each patient's hair sample are characteristic of trichothiodystrophy, a neuro-ectodermal symptom complex which may represent a final common pathway of more than one metabolic disturbance.
Interleukin-6 Spillover in the Peripheral Circulation Increases With the Severity of Heart Failure, and the High Plasma Level of Interleukin-6 Is an Important Prognostic Predictor in Patients With Congestive Heart Failure
Authors: Takayoshi Tsutamoto, Tomoko Hisanaga, Atsuyuki Wada, Keiko Maeda, Masato Ohnishi, Daisuke Fukai, Naoko Mabuchi, Masahide Sawaki, Masahiko Kinoshita
Journal: Journal of the American College of Cardiology (1998)
Deoxyribonucleic acid polymorphism of the apoprotein AI-CIII-AIV gene cluster and coronary heart disease in non-insulin-dependent diabetes.
Authors: R C Trembath, D J Thomas, T J Hendra, J S Yudkin, D J Galton
Journal: BMJ (1987)

The prevalence of an uncommon allelic variant (S2) of the apoprotein AI-CIII-AIV gene cluster was determined in non-insulin-dependent diabetics with or without evidence of coronary heart disease and in controls. Frequencies of the S2 allele were 14% for diabetics with coronary heart disease compared with 2% for non-diabetics with no clinical evidence of occlusive vascular disease. No subject with the S2 allele was detected among a further group of matched diabetics without clinical features of macrovascular disease. The results suggest that a genetic component contributes to the susceptibility to coronary heart disease in non-insulin-dependent diabetics. Whether the observed deoxyribonucleic acid variant is aetiological for atherosclerosis or in linkage disequilibrium with other atherogenic loci on chromosome 11 remains to be clarified.
PRIMARY CUTANEOUS ACTINOMYCOSIS: WITH A NOTE ON THE BACILLUS ACTINOMYCETEM COMITANS.
Authors: ROBERT KLABER
Journal: British Journal of Dermatology (1934)

Journal Article PRIMARY CUTANEOUS ACTINOMYCOSIS: WITH A NOTE ON THE BACILLUS ACTINOMYCETEM COMITANS. Get access ROBERT KLABER, M.D.Lond., M.R.C.P. ROBERT KLABER, M.D.Lond., M.R.C.P. Physician for Skin‐Diseases, Prince of Wales's General Hospital; Clinical Assistant, Skin‐Department, St. Bartholomew's Hospital Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology and Syphilis, Volume 46, Issue 1, 1 January 1934, Pages 12–19, https://doi.org/10.1111/j.1365-2133.1934.tb11118.x Published: 01 January 1934
Mefenamic Acid for Dysmenorrhea-Reply
Authors: Penny Wise Budoff
Journal: JAMA (1979)

<h3>In Reply.—</h3> It is becoming increasingly apparent that antiprostaglandin drugs are the treatment of choice for alleviating the pain of dysmenorrhea. They are safer than both narcotics and oral contraceptives. I chose to investigate mefenamic acid in 1976 after reading of the effectiveness of a sister fenamate used in a small Israeli study. I began the drug treatment at the onset rather than before menses for two reasons: (1) to prevent the inadvertent taking of the drug by an unknowingly pregnant patient, and (2) to medicate with the smallest possible effective dose. Drug safety has always been utmost in my mind. I have taken the drug myself during the past 3 1/2 years, as have some 300 of my patients. The<i>Medical Letter</i>, which is referred to by Souney et al, issued its report based on a small study of drug reactions dating from the early 1960s. Current information, based
Criteria for Malignancy in Gastrointestinal Endocrine Tumors
Authors: Cesare Bordi, Tiziana D'Adda, Cinzia Azzoni, Silvia Pizzi, Lorena Bottarelli, Francesca Mormandi, Tommaso Antonetti, Tu Vinh Luong, Guido Rindi
Journal: Endocrine Pathology (2006)
Lead in bone: implications for toxicology during pregnancy and lactation.
Authors: E K Silbergeld
Journal: Environmental Health Perspectives (1991)

Advances in understanding the distribution and retention of lead in mineralized tissues are important for two reasons: first, bone lead may be a more accurate dosimeter of integrated absorption associated with chronic exposures, and second, bone lead may be a source of internal exposure to the host organism. Little attention has been paid to this second aspect, the remobilization of lead from bone. Mobilization of lead from bone is likely to occur during periods of altered mineral metabolism; since calciotropic factors determine the uptake and storage of lead in this compartment, changes in calcium-related regulatory factors are likely to affect lead compartmentation. Calcium metabolism changes drastically in humans during pregnancy and lactation; although relatively little is known of lead kinetics during these critical periods, it is likely that bone lead is mobilized and transferred to the more bioavailable compartment of the maternal circulation, with potential toxic effects on the fetus and the mother.