HETEROTOPIA OF BONE MARROW SIMULATING MEDIASTINAL TUMOR: A MANIFESTATION OF CHRONIC HEMOLYTIC ANEMIA IN ADULTS
Authors: W. D. Coventry, R. H. Labree
Journal: Annals of Internal Medicine (1960)

Case Reports1 November 1960HETEROTOPIA OF BONE MARROW SIMULATING MEDIASTINAL TUMOR: A MANIFESTATION OF CHRONIC HEMOLYTIC ANEMIA IN ADULTSW. D. COVENTRY, M.D., R. H. LABREE, M.D.W. D. COVENTRY, M.D.Search for more papers by this author, R. H. LABREE, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-53-5-1042 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptA review of several large series of patients with mediastinal tumors1, 2, 3, 4, 5, 6 has failed to reveal a single instance of heterotopic bone marrow. As these tumors can grow to a size easily visible on the x-ray film, and as no previous descriptions have been found in the American literature, we report a case recently studied.Intrathoracic tumors of bone marrow are found only in adults with hemolytic disease of long duration. They tend to increase in size as the hemolytic process continues with advancing age. Most of the well documented cases have been associated with acholuric...Bibliography1. Morrison IM: Tumours and cysts of the mediastinum, Thorax 13: 294-307, 1958. CrossrefMedlineGoogle Scholar2. Schlumberger HG: Tumors of the mediastinum, National Research Council, Committee on Pathology, Section V, Fasc. 18, 1951, Armed Forces Institute of Pathology, Washington, D. C. Google Scholar3. CurreriGale ARJS: Mediastinal tumors, Arch. Surg. 58: 797-818, 1949. CrossrefMedlineGoogle Scholar4. PeabodyStrugReves JWLHJD: Mediastinal tumors, Arch. Int. Med. 93: 875-893, 1954. CrossrefGoogle Scholar5. Harrington SW: Extrapulmonary intrathoracic tumors. Clinical manifestations and surgical treatment, Minnesota Med. 36: 953-960, 1953. MedlineGoogle Scholar6. Blades B: Mediastinal tumors: report of cases treated at Army Thoracic Surgery Centers, Ann. Surg. 123: 749-765 (May) 1946. CrossrefGoogle Scholar7. Brannan D: Extramedullar hematopoiesis in anemias, Bull. Johns Hopkins Hosp. 41: 104, 1927. Google Scholar8. Guizetti P: Haemolyticher kongenitaler Ikterus, Beitr. z. path. Anat. u. z. allg. Path. 52: 15-50, 1912. Google Scholar9. Ask-Upmark E: Tumor simulating intrathoracic heterotopia of bone marrow, Acta radiol. 26: 425, 1945. CrossrefGoogle Scholar10. ParafDecroixCaroli AGJ: Hemolytic anemia in adults and mediastinal tumors: intrathoracic medullary heterotopias, Semaine d. hôp. Paris 33: 493-502, 1957. Google Scholar11. Bamatter F: Recherches anatomo-cliniques sur l'ictire hemolytique constitutionnel familial. Contribution a lletude des formations mycloides prevertibrales, Sang 6: 1-56, 1932. Google Scholar12. Glease HH: Paravertebral heterotopia of bone marrow in a case of acholuric jaundice, J. Path. and Bact. 42: 538-539, 1936. Google Scholar13. VaughanDeterlingSmith RHRAFM: Successful excision of an aortic aneurysm explored as a paraspinal tumor, New England J. Med. 253: 15-17, 1955. CrossrefMedlineGoogle Scholar14. Petri E: Marrow in retroperitoneal fat, Virchows Arch. f. path. Anat. 258: 37, 1925. CrossrefGoogle Scholar15. Cone SM: Bone marrow occurring in intercostal veins, J. A. M. A. 84: 1732, 1925. CrossrefGoogle Scholar16. HanfordSchneiderMacCarthy RBGFJD: Massive thoracic extramedullary hemopoiesis, New England J. Med. 263: 120-123, 1960. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Duluth, Minnesota*Received for publication November 23, 1959.From the Departments of Internal Medicine and Surgery, The Duluth Clinic, Duluth, Minnesota.Requests for reprints should be addressed to W. D. Coventry, M. D., 205 West Second Street, Duluth, Minnesota. 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