Transmission of Human Immunodeficiency Virus by Transplantation of a Renal Allograft, with Development of the Acquired Immunodeficiency Syndrome
Authors: PREM KUMAR
Journal: Annals of Internal Medicine (1987)

Brief Reports1 February 1987Transmission of Human Immunodeficiency Virus by Transplantation of a Renal Allograft, with Development of the Acquired Immunodeficiency SyndromePREM KUMAR, M.D., JAMES E. PEARSON, M.S., DAVID H. MARTIN, M.D., STEPHEN H. LEECH, M.D., Ph.D., PAUL D. BUISSERET, M.D., HELEN C. BEZBAK, M.D., FRANCISCO M. GONZALEZ, M.D., JOHN R. ROYER, M.D., H. Z. STREICHER, M.D., W. CARL SAXINGER, Ph.D.PREM KUMAR, M.D.Search for more papers by this author, JAMES E. PEARSON, M.S.Search for more papers by this author, DAVID H. MARTIN, M.D.Search for more papers by this author, STEPHEN H. LEECH, M.D., Ph.D.Search for more papers by this author, PAUL D. BUISSERET, M.D.Search for more papers by this author, HELEN C. BEZBAK, M.D.Search for more papers by this author, FRANCISCO M. GONZALEZ, M.D.Search for more papers by this author, JOHN R. ROYER, M.D.Search for more papers by this author, H. Z. STREICHER, M.D.Search for more papers by this author, W. CARL SAXINGER, Ph.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-106-2-244 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptHuman immunodeficiency virus (HIV) can be transmitted by seminal fluid and the transfusion of blood and blood products. This case report shows that organ donors may be a source for HIV infection.Recipient: A 38-year-old woman received a renal transplant in 1982 from her HLA-identical brother. Antirejection therapy consisted of prednisone and azathioprine. During the first hospitalization, she developed fever, for which no explanation was found.Subsequently, she had three additional prolonged hospitalizations for the evaluation of fever. On the first of these, 6 weeks after transplantation, her total leukocyte count was 2700/mm3with 70% polymorphonuclear cells, 5% band forms,...References1. SAXINGERLEVINEDEAN WPA. Evidence for exposure to HTLV-III in Uganda before 1973. Science. 1985;227:1036-8. CrossrefMedlineGoogle Scholar2. MATHUR-WAGHENLOWSPIGLAND URI. Longitudinal study of persistent generalised lymphadenopathy in homosexual men: relation to acquired immunodeficiency syndrome. Lancet. 1984;1:1033-8. CrossrefMedlineGoogle Scholar3. JAFFEFEORINODARROW HPW. Persistent infection with human T-lymphotropic virus type III/lymphadenopathy-associated virus in apparently healthy homosexual men. Ann Intern Med. 1985;102:627-8. LinkGoogle Scholar4. ORSIHOWARDBATURAYENDERIBOTESLAMI EJNNSH. High incidence of virus isolation from donor and recipient tissues associated with renal transplantation. Nature. 1978;272:372-3. CrossrefMedlineGoogle Scholar5. ESTEBANSHIHTAIBODNERKAYALTER JJCAJH. Importance of western blot analysis in predicting infectivity of anti-HTLV-III/LAV positive blood. Lancet. 1985;2:1083-6. CrossrefMedlineGoogle Scholar6. PETERMANJAFFEFEORINO THP. Transfusion-associated acquired immunodeficiency syndrome in the United States. JAMA. 1985;254:2913-7. CrossrefMedlineGoogle Scholar7. LARSONFEATHERSTONEPETERSDORF EHR. Fever of undetermined origin: diagnosis and follow-up of 105 cases, 1970-1980. Medicine (Baltimore). 1982;61:269-92. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Louisiana State University Medical Center New Orleans, Louisiana Highland Medical Group Los Angeles, California National Cancer Institute Bethesda, Maryland PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByHuman Immunodeficiency Virus Organ TransplantationDonor-derived Infections after Organ TransplantationOrgan Transplantation and HIV Progress or Success? 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HUMPHRIES, M.D.Practical diagnostic testing for human immunodeficiency virusCase Study One Human Immunodeficiency Virus (HIV) and the Acquired Immunodeficiency Syndrome (AIDS)Infection in Relation to Thoracic TransplantationSpenderkonditio und Organprotektion 1 February 1987Volume 106, Issue 2Page: 244-245KeywordsAIDSBlood transfusionCellsFeversHIVHIV infectionsHospitalizationsRenal transplantationTransplantation Issue Published: 1 February 1987 PDF DownloadLoading ...