tbuckley/cabot-search huggingface dataset:
Abstract 3228: Preparation and in vivo evaluation of a phytosphingosine derivative, N,N,N-Trimethylphytosphingosine (TMP), in liposomes for the treatment of tumor metastasis
Authors: Chung Kil Song, Prabagar Balakrishnan, Chang-Koo Shim, Suk-Jae Chung, Saeho Chong, Myeong Jun Choi, Dae-Duk Kim
Journal: Cancer Research (2011)

Abstract Purpose: The aim of this study is to evaluate the cytotoxicity and anti-metastatic effect of a phytosphingosine derivative, N,N,N-trimethylphytosphingosine.iodide (TMP-I), and to compare it with that of TMP-I liposome. Background: Sphingolipids are known for ortho-signaling and anti-adhesion features as well as intracellular signal messenger in cell differentiation, proliferation and apoptosis. Sphingosine and sphinganine, structural analogs of sphingolipids were recognized as negative modulator of transmembrane signaling through protein kinase C (PKC) that plays an important role in the cancer treatment. Among them, phytosphingosine has been known for antitumor and anti-invasive effect through phytosphingosine-induced apoptosis mechanism. Recently it has been reported that N-monomethylphytosphingosine and N,N-dimethylphytosphingosine induced apoptosis via mitochondria-involved apoptosis such as caspase-8, caspase-3 and caspase-9 and this prompt us for this study. Methods: TMP-I solution was evaluated for cytotoxicity in various cancer cell lines and hemolysis in rat blood cells at various concentrations. The prepared TMP-I liposomes (DPPC:Chol:TMP-I at 5:5:1 mole ratio) were characterized by particle size and studied for in vitro cytotoxicity, cell migration and in vivo angiogenesis in rats. Furthermore, to evaluate the anti-metastatic effect of TMP-I liposomes, C57BL6 mice (n=5) were inoculated with B16F10 cells in tail vein for direct metastasis and footpad for spontaneous metastasis studies. Results: The prepared TMP-I liposomes were with a mean size of 150 nm. TMP-I solution showed significantly higher cytotoxicity and hemolysis (≥100 μg/ml) compared to that of TMP-I liposomes in several cancer cell lines. TMP-I liposomes showed significantly low cell migration and angiogenesis compared to control formulations. The in vivo study in mice showed that the numbers of lung nodules in the mice treated with TMP-I liposomes were significantly lower compared to that of control formulations. Conclusion: Our results suggested that the TMP-I liposome could be used as a potential carrier for the treatment of tumor metastasis. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 102nd Annual Meeting of the American Association for Cancer Research; 2011 Apr 2-6; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2011;71(8 Suppl):Abstract nr 3228. doi:10.1158/1538-7445.AM2011-3228
Metabolic Abnormalities Characteristic of Dysmetabolic Syndrome Predict the Development of Transplant Coronary Artery Disease
Authors: Hannah Valantine, Peter Rickenbacker, Mariska Kemna, Sharon Hunt, Y.-D. Ida Chen, Gerald Reaven, Edward B. Stinson
Journal: Circulation (2001)

Background —This study examines the hypothesis that metabolic abnormalities of dysmetabolic syndrome are risk factors for transplant coronary artery disease (TxCAD). Methods and Results —Sixty-six patients without overt diabetes, 2 to 4 years after surgery, underwent intracoronary ultrasound (ICUS), measurement of plasma glucose and insulin after oral glucose (75 g), and fasting lipid and lipoproteins. TxCAD incidence by angiography or autopsy was prospectively determined during subsequent follow-up (8 years). Coronary artery intimal thickness (IT) and subsequent outcomes were compared in patients stratified as having “high” versus “low” plasma glucose (&gt;8.9 mmol/L) and insulin (&gt;760 pmol/L) 2 hours after glucose challenge; and “abnormal” versus “normal” fasting lipid and lipoprotein concentrations as defined by the National Cholesterol Education Program. Patients with high glucose or insulin concentrations had greater IT: 0.38±0.05 versus 0.22±0.02 mm, P ≤0.05, and 0.39±0.05 versus 0.20±0.02 mm, P ≤0.01, respectively. Freedom from TxCAD was 56±11% versus 81±6% ( P &lt;0.01) in patients with high versus low glucose and 57±10% versus 82±7% ( P &lt;0.05) in patients with high versus low insulin. Actuarial survival was 60±12% versus 92±5% ( P &lt;0.005) in patients with high versus low glucose and 72±9% versus 88±6% ( P &lt;0.05) in patients with high versus low insulin. Triglycerides and VLDL were higher and HDL was lower in patients with IT &gt;0.3 mm than with IT ≤0.3 mm. TxCAD incidence was higher in patients with high plasma TG and VLDL and low HDL. Conclusions —These data suggest that insulin resistance plays a role in TxCAD.
Mass Screening for Colorectal Cancer: Are We Ready?
Authors: Charles B. Clayman
Journal: JAMA (1989)

Considerable funds have gone toward publicizing mass screening for breast cancer and cervical cancer; however, less aggressive efforts have been extended in the area of colorectal cancer (CRC) and its precursors. In this issue ofThe Journalis an article authored by a committee of the American Gastroenterological Association and the American Society for Gastrointestinal Endoscopy.<sup>1</sup>The article recommends, without specifying frequency, a digital rectal examination from age 40 years and fecal occult blood tests (FOBT) and flexible sigmoidoscopy from age 50 years for everyone in the average-risk population. In the case of an FOBT with positive results, they advise colonoscopy in every instance. An objective observer would almost surely differ with the advice offered. The air-contrast barium enema examination (ACBEE) with flexible sigmoidoscopy used in the event colonoscopy is not available is relegated to an alternative role. This despite the calculated superior sensitivity of ACBEE when compared with
Effect of aminophylline on coronary reactive and functional hyperaemic response in conscious dogs
Authors: M. J RADFORD, P. A McHALE, N. SADICK, G. G SCHWARTZ, J. C GREENFIELD
Journal: Cardiovascular Research (1984)

Journal Article Effect of aminophylline on coronary reactive and functional hyperaemic response in conscious dogs Get access MARTHA J RADFORD, MARTHA J RADFORD From the Department of Medicine, Division of Cardiology, Duke University Medical Center, 27710 and the Veterans Administration Medical Center, Durham, North Carolina, 27705 Search for other works by this author on: Oxford Academic PubMed Google Scholar PHILIP A McHALE, PHILIP A McHALE From the Department of Medicine, Division of Cardiology, Duke University Medical Center, 27710 and the Veterans Administration Medical Center, Durham, North Carolina, 27705 Search for other works by this author on: Oxford Academic PubMed Google Scholar NORMAN SADICK, NORMAN SADICK From the Department of Medicine, Division of Cardiology, Duke University Medical Center, 27710 and the Veterans Administration Medical Center, Durham, North Carolina, 27705 Search for other works by this author on: Oxford Academic PubMed Google Scholar GREGORY G SCHWARTZ, GREGORY G SCHWARTZ From the Department of Medicine, Division of Cardiology, Duke University Medical Center, 27710 and the Veterans Administration Medical Center, Durham, North Carolina, 27705 Search for other works by this author on: Oxford Academic PubMed Google Scholar JOSEPH C GREENFIELD, Jr JOSEPH C GREENFIELD, Jr * From the Department of Medicine, Division of Cardiology, Duke University Medical Center, 27710 and the Veterans Administration Medical Center, Durham, North Carolina, 27705 *Address for reprint requests: Joseph C Greenfield, Jr, MD, Box 3246, Duke University Medical Center, Durham, North Carolina 27710, USA. Tel: (919) 681-6147. Search for other works by this author on: Oxford Academic PubMed Google Scholar Cardiovascular Research, Volume 18, Issue 6, June 1984, Pages 377–383, https://doi.org/10.1093/cvr/18.6.377 Published: 01 June 1984
The Effects of Diphenylhydantoin Sodium, Glucose and β-Diethylaminoethyl Diphenylpropylacetate Hydrochloride on Cyclopropane-Epinephrine Arrhythmias in the Dog
Authors: C. W. WHITE, ROBERT MEGIRIAN, EDWARD D. SWISS
Journal: Circulation Research (1955)

Diphenylhydantoin sodium, glucose, and β-diethylaminoethyl diphenylpropylacetate hydrochloride were tested for their effects upon the cyclopropane-epinephrine arrhythmias. Diphenylhydantoin in a small dose enhanced the arrhythmias and in a larger dose controlled them when given by vein, but its action following oral administration was uncertain. Glucose increased both the duration and the severity of ventricular ectopic rhythms while β-diethylaminoethyl diphenylpropylacetate increased the dose of epinephrine which initiated them.
Practising safely in the foundation years
Authors: S. Long, G. Neale, C. Vincent
Journal: BMJ (2009)

<h3>ABSTRACT:</h3> Control of soil erosion and associated nonpoint source pollution is essential to improving water quality. The use of compost or mulch blankets as a soil cover can help control soil erosion and provide sustainable alternatives to disposal for many biomass resources. The objective of this study was to investigate the amounts of runoff, erosion, and nutrient losses obtained under simulated rainfall using a variety of compost and mulch materials. Treatments included aged poultry litter, two different types of poultry litter compost, municipal solid waste compost, biosolids compost, food waste compost, yard waste compost, three different types of wood mulch, and bare soil. Results indicated that all of the treatments except for aged poultry litter were effective at reducing total solids loss in the runoff. Nutrient losses from most of the compost treatments, however, were higher than those from bare soil or mulch treatments. Treatments with lower respiration rates and nitrate-nitrogen concentrations tended to have less erosion and transport of solids. Nitrate-nitrogen content, respiration rates, soluble salt, sodium, and potassium contents were good indicators of ammonium and phosphorus losses.
Erythrocytosis after Zidovudine for AIDS
Authors: Charles A. Kennedy, Harry S. Griffith, Glenn E. Mathisen
Journal: Annals of Internal Medicine (1991)

Letters1 February 1991Erythrocytosis after Zidovudine for AIDSCharles A. Kennedy, MD, Harry S. Griffith, MD, Glenn E. Mathisen, MDCharles A. Kennedy, MDSearch for more papers by this author, Harry S. Griffith, MDSearch for more papers by this author, Glenn E. Mathisen, MDSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-114-3-250 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the Editors: Anemia, granulocytopenia, and myositis appear to be the limiting toxicities in patients receiving zidovudine (1). We report the case of a 29-year-old homosexual man whose hemoglobin concentration paradoxically increased by 9 g/dL over a 4-month period after the institution of zidovudine therapy. Radionuclide studies showed marked expansion of the erythrocyte mass and plasma volume, and dyserythropoietic changes were present in the bone marrow. Serial erythropoietin levels were normal or only mildly elevated. Extensive evaluation for secondary polycythemia or ectopic sources of erythropoietin production was not revealing.In October 1989, a 29-year-old homosexual man presented with nonproductive cough,...References1. Groopman J. Zidovudine intolerance. Rev Infect Dis. 1990;12(Suppl 5):500-7. CrossrefGoogle Scholar2. DarneSoal-CelignyHerrera CPA. Acute myelofibrosis and infection with the lymphadenopathy-associated virus human T-lymphotropic virus type III. Ann Intern Med. 1986;104:130-1. LinkGoogle Scholar3. BattanOttavianoPorcelliDistenfeld RPMA. Polycythemia in a patient with AIDS. Lancet. 1990;1:1342-3. CrossrefGoogle Scholar4. WillacksLudlamWelsby LCP. Polycythemia and HIV infection. Lancet. 1990;2:812-3. CrossrefGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: UCLA School of Medicine Los Angeles, CA PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByTestosterone replacement therapy and polycythemia in HIV-infected patientsIntranasal delivery of zidovudine by PLA and PLA–PEG blend nanoparticlesPolycythemia in patients infected with human immunodeficiency virus-1Solid lipid nanoparticles as drug carriersPolycythemia vera in a patient with acquired immunodeficiency syndromeSelected Red Cell DisordersHuman retroviruses 1 February 1991Volume 114, Issue 3Page: 250-251KeywordsAnemiaAttentionBone marrowErythropoietinHemoglobinHomosexualsMyositisPlasma volumePolycythemiaToxicity Issue Published: 1 February 1991 PDF DownloadLoading ...
Parenting Your Premature Baby
Authors: Paul B. Yellin
Journal: JAMA (1990)

Parents of a premature baby experience much that reinforces any questions they may have about their parenting skills. They must first deal with feelings of guilt and anger concerning the very fact of the premature birth. Next, they are confronted with their baby's need for specialized care in an environment that makes them feel, at best, uncomfortable and anxious and, at worst, in the way. They may experience feelings of ambivalence about their baby and the guilt that such feelings may cause. They may have concerns that their baby may die or be seriously handicapped. Too often, parenting issues come up only at the time of discharge, when the parents are expected to suddenly assume complete responsibility for a baby who several hours earlier was under the care of professionals around-the-clock. Unhappily, dysfunctional parent-child relationships are not uncommon for this group of children. In an excellent new book,<i>Parenting Your</i>
A single myocardial stretch or decreased systolic fiber shortening stimulates the expression of heat shock protein 70 in the isolated, erythrocyte-perfused rabbit heart.
Authors: A A Knowlton, F R Eberli, P Brecher, G M Romo, A Owen, C S Apstein
Journal: Journal of Clinical Investigation (1991)

The regulation of heat shock protein 70 (HSP 70) expression was examined in the isolated, red blood cell-perfused rabbit heart by Northern and Western blot analysis. In the isovolumic (balloon in left ventricle), isolated perfused heart, HSP 70 mRNA was increased threefold after 30 min and sevenfold at 2 and 4 h compared to normal, nonperfused hearts. To further elucidate the etiology of the increase in HSP 70 mRNA, the effects of decreased systolic shortening (isovolumic heart) and of a single ventricular stretch were examined. Perfusion without the application of a stretch or the presence of a balloon resulted in no increase in HSP 70 mRNA; while a single stretch resulted in a threefold increase in HSP 70 mRNA. These changes were accompanied by an increase in HSP 70 protein by Western blot analysis. To elucidate the signalling mechanism mediating the increase in HSP 70, hearts were perfused with H7, a protein kinase C inhibitor. H7 did not prevent the induction of HSP 70. These results indicate that initiation of expression of myocardial HSP 70 can be stimulated by a single myocardial stretch or by prevention of systolic shortening. These mechanisms may contribute to the rapid expression of HSP 70 after coronary occlusion when dyskinesis, reduced systolic shortening, and increased diastolic segment length all occur.
ETHICS AND EXPERIMENTAL THERAPY
Authors: Henry K. Beecher
Journal: JAMA (1963)

Scrupulous care for the welfare of his patient is the greatest concern of the conscientious clinician. There are times, however, when what is called the highest ethical approach can have devastating results. It may be useful to inspect such a situation. In recent years increasing awareness of the power of suggestion, the power of placebos, the importance of nonspecific forces surrounding disease and the treatment of disease, evidence that extreme anxiety can kill—all of these things have led to the conviction that certain supposed results of specific therapy may in truth be consequences of suggestion. There was, for example, in one carefully controlled study, the case of a man with angina pectoris who after 4 min of standardized exercise had intolerable pain with inversion of his T-waves. After operation he was able to exercise 10 min with no pain and no inversion of his T-waves. But in this case the
Capillary Circulation
Authors: Naci M. Bor
Journal: JAMA (1962)

ACCORDING to prevailing opinion, shock is an absolute or relative decrease in blood volume combined with reduced cardiac output, leading to insufficient blood flow to the tissues. It has been demonstrated that arterial blood pressure of patients and experimental animals on complete or partial cardiopulmonary bypass can be maintained at physiological levels by circulating an appropriate amount of blood per minute. It appears from the above statements that application of pump oxygenators to treatment of shock would correct the basic hemodynamic mechanism of this ailment, provided that it also maintains a normal capillary circulation. The experience gained from open-heart operations indicates that procedures conducted with high perfusion rates are followed by more favorable clinical results. Therefore, one can assume that subjects perfused with higher output maintain a more efficient capillary circulation compared to subjects operated with low perfusion rates. However, the extent to which increased blood volume and the rise
A Mediterranean-style diet reduced need for glucose-lowering drugs more than a low-fat diet in type 2 diabetes
Authors: Andrew Mente
Journal: Annals of Internal Medicine (2009)

Source Citation Esposito K, Maiorino MI, Ciotola M, et al. Effects of a Mediterranean-style diet on the need for antihyperglycemic drug therapy in patients with newly diagnosed type 2 diabetes: a randomized trial. Ann Intern Med. 2009;151:306-14. 19721018
Insight into the heterogeneity of breast cancer through next-generation sequencing
Authors: Hege G. Russnes, Nicholas Navin, James Hicks, Anne-Lise Borresen-Dale
Journal: Journal of Clinical Investigation (2011)

Rapid and sophisticated improvements in molecular analysis have allowed us to sequence whole human genomes as well as cancer genomes, and the findings suggest that we may be approaching the ability to individualize the diagnosis and treatment of cancer. This paradigmatic shift in approach will require clinicians and researchers to overcome several challenges including the huge spectrum of tumor types within a given cancer, as well as the cell-to-cell variations observed within tumors. This review discusses how next-generation sequencing of breast cancer genomes already reveals insight into tumor heterogeneity and how it can contribute to future breast cancer classification and management.
Repeated bile acid therapy for the long-term management of cholesterol gallstones
Authors: Maria L. Petroni, Riadh P. Jazrawi, Alberto Lanzini, Massimo Zuin, Paolo Pazzi, Mario Fracchia, Elezabetta Boga, Daniella Facchinetti, Vittorio Alvisi, Giovanni Galatola, J.Martin Bland, Ken W. Heaton, M. Podda, Tim C. Northfield
Journal: Journal of Hepatology (1996)
Keratinocyte growth factor augments immune reconstitution after autologous hematopoietic progenitor cell transplantation in rhesus macaques.
Authors: Ruth Seggewiss, Karin Loré, F. Javier Guenaga, Stefania Pittaluga, Joseph Mattapallil, Catherine K. Chow, Richard A. Koup, Kevin Camphausen, Martha C. Nason, Martin Meier-Schellersheim, Robert E. Donahue, Bruce R. Blazar, Cynthia E. Dunbar, Daniel C. Douek
Journal: Blood (2007)
Differential protein occupancy profiling of the mRNA transcriptome
Authors: Markus Schueler, Mathias Munschauer, Lea Haarup Gregersen, Ana Finzel, Alexander Loewer, Wei Chen, Markus Landthaler, Christoph Dieterich
Journal: Genome biology (2014)

Abstract Background RNA-binding proteins (RBPs) mediate mRNA biogenesis, translation and decay. We recently developed an approach to profile transcriptome-wide RBP contacts on polyadenylated transcripts by next-generation sequencing. A comparison of such profiles from different biological conditions has the power to unravel dynamic changes in protein-contacted cis -regulatory mRNA regions without a priori knowledge of the regulatory protein component. Results We compared protein occupancy profiles of polyadenylated transcripts in MCF7 and HEK293 cells. Briefly, we developed a bioinformatics workflow to identify differential crosslinking sites in cDNA reads of 4-thiouridine crosslinked polyadenylated RNA samples. We identified 30,000 differential crosslinking sites between MCF7 and HEK293 cells at an estimated false discovery rate of 10%. 73% of all reported differential protein-RNA contact sites cannot be explained by local changes in exon usage as indicated by complementary RNA-seq data. The majority of differentially crosslinked positions are located in 3′ UTRs, show distinct secondary-structure characteristics and overlap with binding sites of known RBPs, such as ELAVL1. Importantly, mRNA transcripts with the most significant occupancy changes show elongated mRNA half-lives in MCF7 cells. Conclusions We present a global comparison of protein occupancy profiles from different cell types, and provide evidence for altered mRNA metabolism as a result of differential protein-RNA contacts. Additionally, we introduce POPPI, a bioinformatics workflow for the analysis of protein occupancy profiling experiments. Our work demonstrates the value of protein occupancy profiling for assessing cis -regulatory RNA sequence space and its dynamics in growth, development and disease.
Fatal Rupture of Retro-pharyngo-oesophageal Abscess
Authors: W. F. T. McMath, A. Pereira
Journal: BMJ (1954)

ACHLORHYDRIC ANAEMIAand my colleagues at the German Hospital and their corre- spondents for being able to use this material.November, 1936.-Thepatient was queer in the head and very forgetful (out-patient department).Complete achylia even after histamine.February, 1937.-Out-patient at Maudsley Hospital.Summer, 1942.-Still had unreality feelings (face); tongue protruded slightly to right; right plantar reflexes doubtful; spleen moderately enlarged; question of " splenic anaemia ; sternal puncture said to show a typical megaloblastic picture; C.I. usually against Addisonian anaemia.October, 1942.-Dr.Wyburn-Mason, at the National Hos- pital, Queen Square, found no definitely abnormal -physical signs in the central nervous system.The right plantar reflex was not so definitely flexor as the left, but there was no doubt that it was flexor.The only other finding was a left
TCT-87 Frequency And Impact Of Intraprocedural Thrombotic Events During Percutaneous Coronary Intervention In Women Compared To Men: Pooled Analysis From The ACUITY And HORIZONS-AMI Trials
Authors: Mikkel Schoos, Roxana Mehran, Usman Baber, Ke Xu, Frederick Feit, Bernard j Gersh, E. Magnus Ohman, Bernhard Witzenbichler, Gregg W. Stone
Journal: Journal of the American College of Cardiology (2014)
THE PRESENT POSITION OF GALLSTONE SURGERY.
Authors: WILLIAM WOTKYNS SEYMOUR
Journal: JAMA (1903)

Over a quarter of a century has passed since Marion Sims did the first planned operation for gallstones, and sufficient time has now elapsed to permit a fairly correct judgment as to the present position of gallstone surgery. But before gallstone surgery will show its best results the profession as a whole must recognize that there are no solvents which will dissolve gallstones in the gall bladder and bile ducts, and must, furthermore, recognize their own culpability if operative interference is delayed until the vital powers are exhausted. No field of surgery gives greater relief from agonizing pain, or gives greater capacity to do one's normal work than judicious early operations for gallstone disease. Not for an instant would I be understood as advocating operation in every case of pronounced gallstone colic. But when the attacks recur frequently, show a tendency to increase in severity, and become more and more