tbuckley/cabot-search huggingface dataset:
Abstract P165: Trends in Diabetes by Socioeconomic Status between 1999-2010: National Health and Nutrition Examination Surveys
Authors: Mercedes R Carnethon, Peter John D De Chavez, Laura J Rasmussen-Torvik, Veronica Womack, Kiarri Kershaw
Journal: Circulation (2014)

Background: Diabetes (DM) is more common among adults with lower socioeconomic status (SES). However, it is not known whether the socioeconomic disparities in DM are obscured by the overall rising prevalence of DM. Our objective was to test whether disparities in diabetes by SES have changed between 1999 and 2010. Methods: Participants from National Health and Nutrition Examination Surveys aged &gt; 20 years with data available to determine DM at each examination were included (n= 11,952). DM was determined as fasting glucose ≥126 mg/dL or self-report of DM medication use. Educational attainment was used to represent SES and categorized into 4 groups. Predictive marginal probabilities from logistic regression models were used to calculate the age-standardized prevalence of DM by educational category across 3 survey periods (1999-2002, 2003-2006, 2007-2010). We tested whether the relationship of SES with DM changed over time using interaction terms between education and survey period. Results: The age-standardized prevalence of diabetes was 8.5% (95% CI: 7.3-9.7) in 1999-2002, 9.6% (95% CI: 8.4-10.7) in 2003-2006 and 11.3% (95% CI: 10.0-12.5) in 2007-2010. In each survey period, DM prevalence was highest among adults with the least education (p&lt;0.01) and that relationship did not change over time (p=0.50 for education*year). When we stratified by race/ethnicity, non-Hispanic whites and blacks had the same socioeconomic patterning over time as the total population (Figure). However, education was not associated with DM in Mexican Americans, and this did not change over time. Conclusion: Socioeconomic disparities in DM persist over time; however, the inverse gradient in DM prevalence is not present in Mexican Americans.
High Platelet Reactivity on Clopidogrel Therapy Correlates With Increased Coronary Atherosclerosis and Calcification
Authors: Amala P. Chirumamilla, Akiko Maehara, Gary S. Mintz, Roxana Mehran, Sunil Kanwal, Giora Weisz, Ahmed Hassanin, Diaa Hakim, Ning Guo, Usman Baber, Robert Pyo, Jeffrey W. Moses, Martin Fahy, Jason C. Kovacic, George D. Dangas
Journal: JACC. Cardiovascular imaging (2012)
Mutations in the gene encoding lecithin retinol acyltransferase are associated with early-onset severe retinal dystrophy
Authors: Debra A. Thompson, Yun Li, Christina L. McHenry, Thomas J. Carlson, Xiaoling Ding, Paul A. Sieving, Eckart Apfelstedt-Sylla, Andreas Gal
Journal: Nature Genetics (2001)
Altered Myocardial Substrate Metabolism and Decreased Diastolic Function in Nonischemic Human Diabetic Cardiomyopathy
Authors: Luuk J. Rijzewijk, Rutger W. van der Meer, Hildo J. Lamb, Hugo W.A.M. de Jong, Mark Lubberink, Johannes A. Romijn, Jeroen J. Bax, Albert de Roos, Jos W. Twisk, Robert J. Heine, Adriaan A. Lammertsma, Johannes W.A. Smit, Michaela Diamant
Journal: Journal of the American College of Cardiology (2009)
11-WEEK COURSE OF SEQUENTIAL METHOTREXATE, THORACIC IRRADIATION, AND MODERATE-DOSE CYCLOPHOSPHAMIDE FOR "LIMITED"-STAGE SMALL-CELL BRONCHOGENIC CARCINOMA
Authors: N Thatcher, R.D Hunter, S Jegarajah, P.V Barber, K.B Carroll, P.M Wilkinson, D Crowther
Journal: The Lancet (1982)
Disease-derived extracellular matrix scaffolds instruct the transdifferentiation and migration of lung fibroblasts
Authors: Gerald Burgstaller, Sarah Vierkotten, Melanie Königshoff, Oliver Eickelberg
Journal: European Respiratory Journal (2014)

Introduction: Migration of activated fibroblasts within the alveolar compartment, their transition to myofibroblasts, and extensive secretion of extracellular matrix (ECM) constituents are indicative for active fibrogenesis.  Aims/Objectives:  We investigated whether the ECM from fibrotic tissue can instruct the transdifferentiation and migration of reseeded primary and immortalized lung fibroblasts.  Methods:  Lung slices (300 µm vibratome cuts) from PBS-, elastase- or bleomycin-treated mice were decellularized by treatment with deionized water for 16 hours, 0.1 % SDS for 4h, 1 M NaCl for 2h and 30 µg/ml DNAse for 1h. Lung slices were repopulated with mouse MLg and primary lung fibroblasts (10 6  cells/ml).  Results:  Immunohisto- and immunofluorescence-stainings showed that the basic ECM structure was preserved after decellularization. 4D live-cell imaging revealed that cells attached and spread to the ECM scaffold. Airway structures and vessels were completely repopulated, demonstrating cell proliferation on the scaffold for as long as 9 days, corroborated by Ki67 staining. Fibroblasts attached to the ECM scaffold by forming Vinculin and Talin positive focal adhesions. Depending on their local ECM microenvironment in the slice, reseeded fibroblasts displayed a high plasticity in morphology and migration. Furthermore, transdifferentiation to aSMA positive fibroblasts was accumulated in the peripheral pleural area, partially in vessel/airway structures but rarely in the alveolar space. Conclusion: Fibroblasts seeded on decellularized lung scaffolds displayed a huge plasticity in morphology, migratory behavior and aSMA expression as a function of the ECM microenvironment.
UVEOPAROTITIS; A REPORT OF TWO CASES
Authors: William Harbin, Thomas S. Harbin
Journal: Annals of Internal Medicine (1942)

Case Reports1 February 1942UVEOPAROTITIS; A REPORT OF TWO CASESWILLIAM HARBIN JR., M.D., F.A.C.P., THOMAS S. HARBIN, B.S.WILLIAM HARBIN JR., M.D., F.A.C.P.Search for more papers by this author, THOMAS S. HARBIN, B.S.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-16-2-360 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptDuring recent years there has been a decided increase in the number of reported cases of uveoparotitis. A rather comprehensive review of the literature reveals that approximately 100 such cases have been reported, less than 20 of which come from America and the remainder from foreign countries, chiefly Scandinavia, England and Germany. The rarity of this syndrome warrants the mention of additional cases and the careful scrutiny of these entities with regard to etiology.Parotitis, uveitis, and a low grade fever are the essential features of this condition. Prodromal symptoms, lasting for several weeks or months, include general malaise, drowsiness,...Bibliography1. HEERFORDT CF: Über eine " Febris Uveoparotides subchronica " an der Glandula Parotitis und der Uvea des Auges lokaliziert und häufig mit Paresen cerebrospinaler Nerven kompliziert, Arch. f. Ophth., 1909, lxx, 254. Google Scholar2. GARLANDTHOMPSON HGJG: Uveo-parotid tuberculosis, Quart. Jr. Med., 1933, ii, 157. Google Scholar3. SAVIN LH: An analysis of the signs and symptoms of sixty-six published cases of the uveoparotid syndrome, Trans. Ophth. Soc. United Kingdom, 1934, liv, 549. Google Scholar4. FOLGER HP: Uveoparotitis (Heerfordt), Arch. Ophth., 1936, xv, 1098. CrossrefGoogle Scholar5. LEVIN PM: The neurological aspect of uveo-parotid fever, Jr. Nerv. and Ment. Dis., 1935, lxxxi, 176. CrossrefGoogle Scholar6. COHENRABINOWITZ SJMA: Uveoparotitis, Jr. Am. Med. Assoc., 1935, cv, 496. CrossrefGoogle Scholar7. LEWISRAINESSTEWART GERDS: Uveoparotitis, Lancet, 1936, ii, 1204. CrossrefGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Rome, Georgia*Received for publication May 28, 1940. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 February 1942Volume 16, Issue 2Page: 360-365KeywordsEtiologyFeversParotitisUveitis ePublished: 1 December 2008 Issue Published: 1 February 1942 PDF downloadLoading ...
Dentinogenesis imperfecta 1 with or without progressive hearing loss is associated with distinct mutations in DSPP
Authors: Shangxi Xiao, Chuan Yu, Xueming Chou, Wenjuan Yuan, Ying Wang, Lei Bu, Gang Fu, Meiqian Qian, Jun Yang, Yaozhou Shi, Landian Hu, Bin Han, Zhengmin Wang, Wei Huang, Jing Liu, Zhu Chen, Guoping Zhao, Xiangyin Kong
Journal: Nature Genetics (2001)
Corrigendum to “Intranasal Administration of the Growth-compromised HSV-2 Vector ΔRR Prevents Kainate-induced Seizures and Neuronal Loss in Rats and Mice”
Authors: Jennifer M Laing, Michael D Gober, Erin K Golembewski, Scott M Thompson, Kymberly A Gyure, Paul J Yarowsky, Laure Aurelian
Journal: Molecular Therapy (2007)

Molecular Therapy (2006) 13, 870–881. doi:10.1016/j.ymthe.2005.12.013 Following the publication of this article, the authors noted that the image shown for preimmune IgG staining in Figure 3d, panel 4 was incorrect. The corrected figure is shown below.
Temperature modulated histamine‐itch in lesional and nonlesional skin in atopic eczema – a combined psychophysical and neuroimaging study
Authors: F. Pfab, M. Valet, T. Sprenger, J. Huss‐Marp, G. I. Athanasiadis, H. J. Baurecht, A. Konstantinow, C. Zimmer, H. Behrendt, J. Ring, T. R. Tölle, U. Darsow
Journal: Allergy (2009)

Itch is the major symptom of many allergic diseases; yet it is still difficult to measure objectively. The aim of this study was to use an evaluated itch stimulus model in lesional (LS) and nonlesional (NLS) atopic eczema (AE) skin and to characterize cerebral responses using functional magnetic resonance imaging (fMRI).Thermal modulation was performed on a histamine stimulus in randomized order on LS or NLS in rapid alternating order from 32 degrees C (warm) to 25 degrees C (cold). Subjective itch ratings were recorded. Additionally, fMRI measurements were used to analyze the cerebral processing (n = 13). Healthy skin (HS) of age-matched volunteers served as control (n = 9).Mean VAS itch intensity was significantly (P < 0.0001) higher during the relative cold [55.2 +/- 8.3% (LS); 48.6 +/- 8.2% (NLS)] compared to the relative warm blocks [36.0 +/- 7.3% (LS); 33.7 +/- 7.6% (NLS)]. Compared to HS, the itch response was delayed in LS and NLS. Itch intensity was perceived highest in LS, followed by NLS and HS. For NLS, fMRI revealed at the beginning of the itch provocation a cerebral deactivation pattern in itch processing structures (thalamus, prefrontal, cingulate, insular, somatosensory and motor cortex). During the course of stimulation, the cerebral deactivation was reduced with time and instead an activation of the basal ganglia occurred. In contrast LS showed an activation instead of deactivation pattern already at the beginning of the stimulation in the above mentioned structures.Moderate short-term temperature modulation led to a reproducible, significant enhancement of histamine-induced itch with the strongest effect in LS. The differences in itch perception and itch kinetics between healthy volunteers and NLS in patients point towards an ongoing central inhibitory activity patients with AE, especially at the beginning of the itch provocation.
RAYNAUD'S DISEASE IN MAN
Authors: A. M. Rechtman
Journal: Annals of Internal Medicine (1936)

Case Reports1 October 1936RAYNAUD'S DISEASE IN MANA. M. RECHTMAN, M.D., F.A.C.S.A. M. RECHTMAN, M.D., F.A.C.S.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-10-4-549 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptRAYNAUD'S disease in man is not common. Only seven cases were seen at the Mayo Clinic1 which fulfilled the criteria Allen and Brown considered necessary for a diagnosis. It is generally conceded that the majority of male patients in whom a diagnosis of Raynaud's disease has been made have in reality been cases of thromboangiitis obliterans.Raynaud described four features whose presence he considered necessary for a diagnosis of the disease bearing his name.1. Episodes of change in color, of the vasospastic type, excited by cold or emotion.2. Bilaterality.3. Presence of normal pulsations in the palpable arteries....References1. ALLENBROWN EVGE: Raynaud's disease affecting men, ANN. INT. MED., 1932, v, 1384-1386. Google Scholar2. BROWN GE: Personal communication, Dec. 12, 1935. Google Scholar3. BROWN GE: Skin capillaries in Raynaud's disease, Arch. Int. Med., 1925, xxxv, 56-73. CrossrefGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Philadelphia, Pennsylvania*Received for publication January 2, 1935. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byDie chemische Untersuchung metallischer WerkstoffeErbbiologie und Erbpathologie des Kreislaufapparates 1 October 1936Volume 10, Issue 4Page: 549-552KeywordsArteriesEmotions ePublished: 1 December 2008 Issue Published: 1 October 1936 PDF downloadLoading ...
Abstract 19066: Quantifying the Years of Life Gained From Myocardial Infarction Admission Process-of-Care Measures
Authors: Emily M Bucholz, Neel M Butala, Sharon-Lise T Normand, Harlan M Krumholz
Journal: Circulation (2014)

Background: Studies evaluating process of care measures for acute myocardial infarction (AMI) have generally demonstrated improved 30-day survival for patients receiving these therapies; however, almost no studies have followed patients beyond 1 year. As a result, there is considerable uncertainty as to whether the early survival benefits persist over the long-term. Methods: We analyzed data from the Cooperative Cardiovascular Project, a study of Medicare beneficiaries hospitalized for AMI between 1994 and 1995, to examine the relationship between 5 AMI admission measures (aspirin, beta-blockers, acute reperfusion therapy, time to percutaneous coronary intervention (PCI) ≤90 minutes, and time to fibrinolysis ≤30 min) and life expectancy after AMI. Patient eligibility for each measure was determined using AHA/ACC guidelines, and vital status over 17 years of follow-up was ascertained through the Medicare Denominator files. Cox proportional hazards regression with extrapolation using exponential models was used to calculate life expectancy after AMI. Results: Our study cohort consisted of 147,429 patients who were eligible for at least one measure. Survival curves for recipients and non-recipients of each core measure separated within the first year and remained distinct over the remainder of follow-up. This pattern was consistent across all five therapies and resulted in significantly longer life expectancies for patients receiving these therapies (Table 1). Differences in life expectancy between recipients and non-recipients decreased but remained significant after adjustment for patient and hospital characteristics. Conclusions: Receipt of 5 AMI admission therapies was associated with significant gains in life expectancy after AMI, lending further support for AMI process of care measures, which can be delivered rapidly at the time of hospitalization.
Continuing Anticoagulation Following Venous Thromboembolism
Authors: Elizabeth Krakow, Thomas L Ortel
Journal: JAMA (2005)

To the Editor: We believe that the study by Dr Ost and colleagues1 of duration of anticoagulation following venous thromboembolism is missing important data on bleeding risk that are needed for clinicians and patients to make fully informed decisions about how long to continue secondary prophylaxis.
When Doctors Join Unions, by Grace Budrys
Authors: Norman Ellis
Journal: BMJ (1998)

Grace Budrys,

Cornell University Press, £11.95, pp 177

ISBN 0 8014 8354 9

The factors militating against American doctors joining unions are so pervasive that to discover any unionised doctors in the United States is a surprise. This book is a case study of the unique circumstances prevailing in California since the 1970s, which have enabled a doctors’ union, the Union of American Physicians and Dentists, to flourish.



A small (12 or 17 mm diameter) umbrella device introduced through a catheter to close a persistent patent ductus arteriosus. From Illustrated Textbook of Paediatrics by Tom Lissauer and Graham Clayden (Mosby, …
Boceprevir for chronic HCV genotype 1 infection.
Authors: Alpna R Limaye, Peter V Draganov, Roniel Cabrera
Journal: New England Journal of Medicine (2011)

To the Editor: Poordad et al. and Bacon et al. (March 31 issue)1,2 report improved rates of sustained virologic response among patients with chronic infection with the hepatitis C virus (HCV) who received boceprevir. Although these rates are similar to those seen among patients who received telaprevir,3-5 the telaprevir studies did not allow erythropoietin use, so there are important distinctions between the two protease inhibitors. In the boceprevir studies, despite erythropoietin use in 41 to 49% of the patients, 2 to 3% of the patients required treatment discontinuation because of anemia. The telaprevir studies3-5 showed similar discontinuation rates without erythropoietin use. Clinically significant anemia might not be tolerated in a larger population of patients with cirrhosis. Erythropoietin carries a Food and Drug Administration black-box warning for possible increases in thromboembolic events. Alpna R. Limaye, M.D. Peter V. Draganov, M.D. Roniel Cabrera, M.D. University of Florida College of Medicine Gainesville, FL cabrer@medicine.ufl.edu
The Unbearable Weight of Ashes
Authors: John A. Vanek
Journal: JAMA (2002)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Therapeutic nursing or unblocking beds? A randomised controlled trial of a post-acute intermediate care unit Commentary: Problems with randomised consent Authors' reply
Authors: A. Steiner
Journal: BMJ (2001)

<h3>Abstract</h3> <b>Objectives:</b> To compare post-acute intermediate care in an inpatient nurse-led unit with conventional post-acute care on general medical wards of an acute hospital and to examine the model of care in a nurse-led unit. <b>Design:</b> Randomised controlled trial with six month follow up. <b>Setting:</b> Urban teaching hospital and surrounding area, including nine community hospitals. <b>Participants:</b> 238 patients accepted for admission to nurse-led unit. <b>Interventions:</b> Care in nurse-led unit or usual post-acute care. <b>Main outcome measures:</b> Patients9 length of stay, functional status, subsequent move to more dependent living arrangement. <b>Results:</b> Inpatient length of stay was significantly longer in the nurse-led unit than in general medical wards (14.3 days longer (95% confidence interval 7.8 to 20.7)), but this difference became non-significant when transfers to community hospitals were included in the measure of initial length of stay (4.5 days longer (−3.6 to 12.5)). No differences were observed in mortality, functional status, or living arrangements at any time. Patients in the nurse-led unit received significantly fewer minor medical investigations and, after controlling for length of stay, significantly fewer major reviews, tests, or drug changes. <b>Conclusions:</b> The nurse-led unit seemed to be a safe alternative to conventional management, but a full accounting of such units9 place in the local continuum of care and the costs associated with acute hospitals managing post-acute patients is needed if nurse-led units are to become an effective part of the government9s recent commitment to intermediate care.
Happy 50th Birthday, Salk Vaccine
Authors: Mike Mitka
Journal: JAMA (2005)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal