Globulin-bound Amylase
Authors: P. WILDING
Journal: Annals of Internal Medicine (1964)

Case Studies1 June 1964Globulin-bound AmylaseA Cause of Persistently Elevated Levels in SerumP. WILDING, B.SC., A.R.I.C., W. T. COOKE, M.D., F.R.C.P., G. I. NICHOLSON, M.R.A.C.P., M.R.C.P.P. WILDING, B.SC., A.R.I.C.Search for more papers by this author, W. T. COOKE, M.D., F.R.C.P.Search for more papers by this author, G. I. NICHOLSON, M.R.A.C.P., M.R.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-60-6-1053 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptRaised serum levels of amylase are associated with acute pancreatitis, mumps, certain acute abdominal conditions, and sometimes after the administration of opiates. According to Gray and Somogyi (1), persistently raised levels are to be found also in patients with impaired renal function, though Gross, Parker, Maher, and Power (2) found no significant increase in 63 patients with renal or extrarenal azotemia.Several attempts have been made to determine whether amylase is associated with any specific protein in the serum. Cattaneo and Bassani (3) showed that amylase can be precipitated with the albumin fraction, using acetone at low temperature. With paper...References1. GRAYSOMOGYI SHM: Relationship between blood amylase and urinary amylase in man. Proc. Soc. Exp. Biol. Med. 36: 253, 1937. CrossrefGoogle Scholar2. GROSSPARKERMAHERPOWER JBTWFTMH: Serum amylase and lipase values in renal and extrarenal azotemia. Gastroenterology 39: 76, 1960. CrossrefMedlineGoogle Scholar3. CATTANEOBASSANI CB: Researches on the enzymatic functions of the protein constituents of serum. Boll. Soc. Ital. Biol. Sper. 13: 424, 1938. Google Scholar4. BAKERPELLEGRINO RWC: The separation and detection of serum enzymes by paper electrophoresis. Scand. J. Clin. Lab. Invest. 6: 94, 1954. CrossrefMedlineGoogle Scholar5. MCGEACHINLEWIS RLJP: Electrophoretic behavior of serum amylase. J. Biol. Chem. 234: 795, 1959. CrossrefMedlineGoogle Scholar6. DREILINGJANOWITZJOSEPHBERG DAHDLD: Serum iso-amylases: An electrophoretic study of the blood amylase and the patterns observed in pancreatic disease. Ann. Intern. Med. 58: 235, 1963. LinkGoogle Scholar7. WILDING P: Use of gel filtration in the study of human amylase. Clin. Chim. Acta. 8: 918, 1963. CrossrefMedlineGoogle Scholar8. VAN LOONLIKINSSEGER EJMRAJ: Photometric method for blood amylase by use of starch-iodine color. Amer. J. Clin. Path. 22: 1134, 1952. CrossrefMedlineGoogle Scholar9. VAN DE KAMERHUININKWEYERS JHHTHA: Rapid method for the determination of fat in feces. J. Biol. Chem. 177: 347, 1949. CrossrefMedlineGoogle Scholar10. COOKEFONECOXMEYNELLGADDIE WTDJEVMJR: Adult celiac disease. Gut 4: 279, 1963. CrossrefMedlineGoogle Scholar11. MCGEACHINHARGAN RLLA: Renal clearance of amylase. Proc. Soc. Exp. Biol. Med. 89: 129, 1956. Google Scholar12. COXMEYNELLCOOKEGADDIE EVMJWTR: The folic acid excretion test in the steatorrhoea syndrome. Gastroenterology 35: 390, 1958. CrossrefMedlineGoogle Scholar13. NELP WB: Acute pancreatitis associated with steroid therapy. Arch. Intern. Med. (Chicago) 108: 702, 1961. CrossrefMedlineGoogle Scholar14. SACHARWEINHAUS LAR: Misinterpretation of elevated blood diastase due to impaired renal clearance. Arch. Surg. (Chicago) 73: 305, 1956. CrossrefGoogle Scholar15. SWEENEYFINKEL DFM: Hyperamylasemia of renal origin in the absence of azotemia. Gastroenterology 45: 756, 1963. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: P. WILDING, B.SC., A.R.I.C.; W. T. COOKE, M.D., F.R.C.P.; G. I. NICHOLSON, M.R.A.C.P., M.R.C.P.Affiliations: Birmingham,From the General Hospital, Birmingham, England.Requests for reprints should be addressed to P. Wilding, Nutrition and Intestinal Unit, The General Hospital, Birmingham 4, England. 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