SOME OBSERVATIONS UPON THE MIDDLEBROOK-DUBOS HEMAGGLUTINATION TEST IN MAN AND ANIMALS
Authors: P BUNN, B DROBECK, J GINO, C ADAIR
Journal: Annals of Internal Medicine (1952)

Article1 July 1952SOME OBSERVATIONS UPON THE MIDDLEBROOK-DUBOS HEMAGGLUTINATION TEST IN MAN AND ANIMALSPAUL BUNN, M.D., BERYL DROBECK, B.S., JEAN GINO, M.D., CHARLES ADAIR, M.D., LEONARD CANARILIPAUL BUNN, M.D.Search for more papers by this author, BERYL DROBECK, B.S.Search for more papers by this author, JEAN GINO, M.D.Search for more papers by this author, CHARLES ADAIR, M.D.Search for more papers by this author, LEONARD CANARILISearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-37-1-84 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe Middlebrook-DuBos test for measurement of circulating hemagglutinins in the sera of tuberculous humans was initially described as a useful tool to aid the clinician in the diagnosis and management of the disease.1, 2 Some reports have indicated that there was practical value in its common usage.3, 4 Other reports have suggested that the test was not of great worth.5, 6 Because some confusion still exists concerning the practical usefulness of the hemagglutination test in the field of tuberculosis, this report describes further observations upon it in man and animals.METHODSThe hemagglutination test was performed substantially by the method...Bibliography1. MiddlebrookDuBos GR: Specific serum agglutination of erythrocytes sensitized with extracts of the tubercle bacillus, J. Exper. Med. 88: 521, 1948. CrossrefMedlineGoogle Scholar2. Middlebrook G: Editorial: The hemagglutination test in tuberculosis, Am. Rev. Tuberc. 62: 121, 1950. MedlineGoogle Scholar3. SmithScott DTNB: Clinical interpretation of the Middlebrook-DuBos hemagglutination test, Am. Rev. Tuberc. 62: 121, 1950. MedlineGoogle Scholar4. RothbardDoonhefHeto SASKE: Practical application of a hemagglutination reaction in tuberculosis, Proc. Soc. Exper. Biol. and Med. 74: 72, 1950. CrossrefMedlineGoogle Scholar5. FlemingRunyonCummings JWEHMM: Evaluation of the hemagglutination test for tuberculosis, Am. J. Med. 10: 704, 1951. CrossrefMedlineGoogle Scholar6. AdcockHaleyDavey JRRWN: Middlebrook hemagglutination test for tuberculosis, J. Lab. and Clin. Med. 38: 736-741 (Nov.) 1951. MedlineGoogle Scholar7. Middlebrook G: Personal communications. Google Scholar8. BunnDrobeck PB: Use of rabbit eye as a tissue to study tuberculosis. I. Development of localized ocular lesion, Am. Rev. Tuberc. 64: 196-201 (Aug.) 1951. Google Scholar9. BunnDrobeck PB: Use of rabbit eye as a tissue to study tuberculosis. III. Effect of adrenal hormones upon course of disease and upon certain immunologic responses. To be published, Am. Rev. Tuberc., 1952. MedlineGoogle Scholar10. DuBos RJ: The hemagglutination test for tuberculosis, Minutes of the Ninth Streptomycin Conference, p. 222, April, 1950. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: *Received for publication January 21, 1952.From the Department of Medicine, State University of New York, Medical School at Syracuse.Aided by grants from Bristol Laboratories, Syracuse, New York, the National Tuberculosis Association, New York, N. Y., and from the Division of Research and Grants, United States Public Health Service.Concentrated tuberculin used in all tests was generously supplied by Dr. H. D. Piersma, Lederle Laboratories, Pearl River, New York.Valuable aid and advice in these studies were given by Miss Winifred Osborne, Department of Bacteriology. Some of the sera studied were from patients of Dr. Stanley Lincoln, Biggs Memorial Hospital, Ithaca, New York. His coöperation is greatly appreciated.Portions of this work have been presented at the Eastern Section meeting of the American College of Physicians, October, 1950, Rochester, New York, and at the Eastern Section meeting of the American Trudeau Society, November, 1951, Hartford, Connecticut. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByThe Value of the Middlebrook-Dubos Hemagglutination Test for Tuberculosis*Beitrag zur Hämagglutinationsreaktion nachMiddlebrook undDubos unter besonderer Berücksichtigung ihrer Bedeutung zur Differentialdiagnose tuberkulöser AugenerkrankungenHemagglutination test of tuberculin-sensitized red cells in leprosy 1 July 1952Volume 37, Issue 1Page: 84-95KeywordsBacteriologyHemagglutinationMedical servicesResearch grantsRiversTuberculin Issue Published: 1 July 1952 PDF DownloadLoading ...