SICKLE CELL ANEMIA WITH STRIKING ELECTROCARDIOGRAPHIC ABNORMALITIES AND OTHER UNUSUAL FEATURES, WITH AUTOPSY
Authors: H. Leonard Jones, Frederick E. Wetzel, Boyd K. Black
Journal: Annals of Internal Medicine (1948)

Case Reports1 November 1948SICKLE CELL ANEMIA WITH STRIKING ELECTROCARDIOGRAPHIC ABNORMALITIES AND OTHER UNUSUAL FEATURES, WITH AUTOPSYH. LEONARD JONES JR., FREDERICK E. WETZEL, BOYD K. BLACKH. LEONARD JONES JR.Search for more papers by this author, FREDERICK E. WETZELSearch for more papers by this author, BOYD K. BLACKSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-29-5-928 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThis case of sickle cell anemia with autopsy is considered worthy of reporting because of the following unusual features: (1) the symptomatology simulating coronary occlusion, with gross electrocardiographic evidence compatible with this condition, in the absence of any histopathologic evidence of myocardial damage other than simple cardiac hypertrophy and dilatation with moderate interstitial edema; (2) the marked sickling of erythrocytes even in the usual blood smear; (3) the coexistence of duodenal ulcer which evoked abdominal pain simulating that often seen in hemolytic crises of sickle cell anemia; (4) the extraordinarily small size of the spleen (5 grams).CASE REPORTHistory....Bibliography1. WINSORBURCH TGE: Electrocardiogram and cardiac state in active sickle-cell anemia, Am. Heart Jr., 1945, xxix, 685-696. CrossrefGoogle Scholar2. KLINEFELTER HF: Heart in sickle cell anemia, Am. Jr. Med. Sci., 1942, cciii, 34-51. CrossrefGoogle Scholar3. ZIMMERMANBARNETT SLRN: Sickle cell anemia simulating coronary occlusion, Ann. Int. Med., 1944, xxi, 1045-1049. Google Scholar4. WINTROBE MM: The cardiovascular system in anemia, with a note on the particular abnormalities in sickle cell anemia, Blood, 1946, i, 121-128. CrossrefGoogle Scholar5. CARTERTRAUT JBEF: Cardiovascular manifestations in pernicious anemia, Arch. Int. Med., 1943, lxxii, 757-766. CrossrefGoogle Scholar6. ELLISFAULKNER LBJM: The heart in anemia, New England Jr. Med., 1939, ccxx, 943-952. CrossrefGoogle Scholar7. WINTROBE MM: Clinical Hematology, 1946, Lea and Febiger, Philadelphia, p. 510. Google Scholar8. HAMILTON J: A case of sickle cell anemia, U. S. Vet. Med. Bull., 1926, ii, 497-502. Google Scholar9. HEINMCCALLATHORNE GERLGW: Sickle cell anemia, with report of a case with autopsy, Am. Jr. Med. Sci., 1927, clxxii, 763-772. CrossrefGoogle Scholar10. YATERMOLLARI WMM: The pathology of sickle-cell anemia. Report of a case with death during an "abdominal crisis," Jr. Am. Med. Assoc., 1931, xcvi, 1671-1675. CrossrefGoogle Scholar11. SYDENSTRICKER VP: Sickle-cell anemia, South. Med. Jr., 1924, xvii, 177-183. CrossrefGoogle Scholar12. ALDEN HS: Sickle-cell anemia; report of two cases from Ohio illustrating its hemolytic nature, Am. Jr. Med. Sci., 1927, clxxiii, 168-175. CrossrefGoogle Scholar13. CARNETT JB: A case of intercostal neuralgia simulating an acute intra-abdominal catastrophe, Surg. Clin. N. Am., 1930, x, 1329-1334. Google Scholar14. LEVYSCHNABEL FETG: Abdominal crisis in sickle cell anemia, Am. Jr. Med. Sci., 1932, clxxxiii, 381-391. CrossrefGoogle Scholar15. STEINBERG B: Sickle cell anemia, Arch. Path., 1930, ix, 876-895. Google Scholar16. RICH AR: Splenic lesions in sickle cell anemia, Bull. Johns Hopkins Hosp., 1928, lxiii, 398-399. Google Scholar17. DIGGS LW: Siderofibrosis of the spleen in sickle cell anemia, Jr. Am. Med. Assoc., 1935, civ, 538-541. CrossrefGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: H. LEONARD JONESJR.; FREDERICK E. WETZEL; BOYD K. BLACK*Received for publication September 17, 1947.The opinions herein stated are those of the authors and not necessarily those of the Medical Department of the U. S. Navy. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byCardiovascular Function and Dysfunction in Sickle Cell AnemiaAcute Myocardial Infarction in Sickle Cell Disease: Case Report and Review of the LiteratureMyocardial infarction in sickle cell anemiaHemodilution - New Clothes for an Anemic EmperorDuodenal ulceration in sickle cell anaemiaGastric acid secretion in sickle-cell anaemiaThe electrocardiogram in sickle-cell anemiaSickle-cell Disease 1 November 1948Volume 29, Issue 5Page: 928-935KeywordsAnemiaAutopsyBlood cellsCardiac hypertrophyDuodenal ulcersEdemaElectrocardiographyHemolytic anemiaPharmacistsSpleen ePublished: 1 December 2008 Issue Published: 1 November 1948 PDF downloadLoading ...