tbuckley/cabot-search huggingface dataset:
Cardiac Lesions in Reiter's Disease
Authors: G. W. Csonka, J. W. Litchfield, J. K. Oates, R. R. Willcox
Journal: BMJ (1961)

Reiter's disease is a condition of unknown aetiology and in its generally recognized form is a triad consisting of urethritis, arthritis, and conjunctivitis.With increasing knowledge a number of characteristic though less constant features have been added to the clinical picture.However, many patients show only two of the cardinal features (commonly urethritis and arthritis), but the -subsequent course is similar to the fully developed -condition, and it is generally assumed that these are variants of a single disease entity.The condition may follow bacillary dysenteries, non-specific diarrhoea, or venereally acquired urethritis, and it most commonly affects young men.Its outstanding feature is acute arthritis, which usually involves several joints and may show a rapid evolution; it has thus some resemblance to rheumatic fever, and this had led investigators to search -for cardiac lesions. LiteratureIn the older literature endocarditis was freely diagnosed on finding systolic murmurs and sometimes vague precordial discomfort soon after the onset of Reiter's disease (Stettner, 1917;Sick, 1918).There was no follow-up of these cases and the clinical evidence ,does not justify the claims made.Later some clinicians used electrocardiography as a routine investigation in Reiter's disease, and abnormal tracings were reported in a fairly high proportion of cases (Master and Jaffe,
X-linked Recessive Inheritance in the Ehlers-Danlos Syndrome
Authors: P. Beighton
Journal: BMJ (1968)

Two families are described in which the Ehlers–Danlos syndrome is apparently transmitted as an X-linked recessive character. The results of tests for the Xg blood groups and for colour vision show that the locus for the Ehlers–Danlos syndrome is not close to that for the Xg groups nor very close to the locus for deutan colour-blindness. The clinical features of this variety of the Ehlers–Danlos syndrome include considerable hyperextensibility of the skin and a bruising tendency.
Complementary and Alternative Medicine Use and All-Cause Mortality among U.S.-Born and Foreign-Born Breast Cancer Cases: Results from the Hereditary Breast and Ovarian Cancer (HBOC) Study.
Authors: L. Bessonova, J. Largent, H. Anton-Culver
Journal: Cancer Research (2009)

Abstract Background: Complementary and alternative medicine (CAM) therapies are used by people from all racial/ethnic backgrounds, and CAM use among cancer patients has recently been a focus of much research. Breast cancer patients, specifically, have embraced many CAM therapies. Use of these therapies is estimated to be between 48 and 70 percent among women diagnosed with breast cancer in the United States (Nahlez and Tabbara, 2003). Mortality patterns in foreign-born women diagnosed with breast and other cancers who immigrate to the United States are complex (Singh and Hiatt, 2006). However, it is unclear how country of birth relates to CAM use and overall survival among women with breast cancer. Therefore, we investigated the associations between country of birth, CAM use, and overall survival in the Hereditary Breast and Ovarian Cancer (HBOC) study, a population-based sample of breast cancer cases in California, comparing U.S.-born versus foreign-born women.Methods: Five hundred and fifty incident breast cancer cases (average age=54.68; SD=11.12) were sampled from the HBOC Study, which were identified through the Orange County regional registry for the state California Cancer Registry. Cases were contacted via telephone, and information on health behaviors, disease history, and socio-demographic characteristics were collected. A self-administered questionnaire queried use of any of the following CAM therapies: herbal teas, megavitamins, acupuncture, religious services, nonreligious services, aspirin, and/or non-prescription pain medicines. Chi-square test followed by Cox proportional hazards regression were used to compare overall survival between U.S.-born and foreign-born breast cancer cases as well as CAM ever- versus never-users.Results: Univariate analyses revealed that 59.5% of foreign-born breast cancer cases, versus 55.7% of U.S.-born reported having ever used CAM (Chi-square=0.76; p=0.38). In multivariate analyses, foreign-born women with breast cancer had roughly 3 times greater risk for all-cause cause mortality (HR=3.38; 95% CI: 2.14, 5.33) compared with U.S.-born breast cancer cases, adjusting for history of CAM use, education, number of existing co-morbidities, stage of tumor at diagnosis, and age at time of survey. Stratified analyses revealed that CAM use was not significantly associated with all-cause mortality using the above multivariate model among foreign-born (HR=1.35; 95% CI: 0.77, 2.37), or U.S.-born breast cancer cases (HR= 2.36; 95% CI: 0.99, 5.64).Discussion: These findings suggest that although foreign-born breast cancer cases are at greater risk for all-cause mortality, history of CAM use does not significantly protect nor increase the risk of death for this population. Citation Information: Cancer Res 2009;69(24 Suppl):Abstract nr 3069.
Impaired Lymphocyte Function in Aged Humans
Authors: Marc E. Weksler, Thomas H. Hütteroth
Journal: Journal of Clinical Investigation (1974)

The response of lymphocytes from young and old persons to phytohemagglutinin, pokeweed mitogen, or allogeneic lymphocytes has been measured. Lymphocytes from old persons incorporated significantly less tritiated thymidine as compared with lymphocytes from young persons when cultured with plant mitogens or allogeneic cells. The difference in observed lymphocyte reactivity could not be attributed to differences in culture conditions required for maximal transformation of lymphocytes from old or young subjects. The same percentage of thymus-derived and bone marrow-derived lymphocytes was found in the blood from old and young persons. The relationship of these findings to the decline of immunologic competence with age is discussed.
TCTAP A-011 Prognostic Importance of Killip Classification in Modern Pharmaco-invasive Treatment Era for the Patients with Acute Myocardial Infarction (Report from Mie ACS Registry)
Authors: Tairo Kurita, Naoto Kumagai, Kouzo Hoshino, Tetsuya Seko, Takafumi Koji, Katsutoshi Makino, Jun Masuda, Takashi Tanigawa, Mashio Nakamura, Ito Masaaki
Journal: Journal of the American College of Cardiology (2014)
Two Cases of Colonic Adenomatous Polyps Accompanied by a Migrated Surgical Suture
Authors: Y. Araki, K. Akahoshi, N. Harada, Y. Chijiiwa, I. Sasaki, H. Nawata
Journal: Endoscopy (2001)

A 56-year-old man and a 70-year-old woman, with histories of left colectomy and appendectomy respectively, were admitted to our hospital. In both cases, colonoscopy showed a pedunculated colonic polyp in the ascending colon, and a silk suture became visible in the stalk during polypectomy. The histological diagnosis was adenoma. These two cases constitute the first report of colonic adenomatous polyps accompanied by suture migration.
Prognosis of Asymptomatic Hepatitis B Surface Antigen Carriers
Authors: Kendo Kiyosawa
Journal: Annals of Internal Medicine (1993)

Letters15 September 1993Prognosis of Asymptomatic Hepatitis B Surface Antigen CarriersKendo Kiyosawa, MD, Takeshi Sodeyama, MD, and Eiji Tananka, MDKendo Kiyosawa, MDSearch for more papers by this author, Takeshi Sodeyama, MDSearch for more papers by this author, and Eiji Tananka, MDSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-119-6-199309150-00020 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:de Franchis and colleagues [1] reported that Italian hepatitis B surface antigen (HBsAg) carriers with initially normal liver function test results have an excellent prognosis and a low risk for developing hepatocellular carcinoma. This differs in Japan. In adult Japanese HBsAg asymptomatic carriers with normal liver function test results and normal liver histology, 40% are hepatitis B e antigen (HBeAg)-positive carriers and 60% are anti-HBe-positive carriers [2]. The prognosis of HBeAg-positive asymptomatic HBsAg carriers appears to be poor. Of 32 HBeAg-positive carriers followed for an average of 13 years (range, 8 to 20 years), 16 (50%) developed ...References1. de Franchis R, Meucci G, Vecchi M, Tatarella M, Colombo M, Del Ninno E, et al. The natural history of asymptomatic hepatitis B surface antigen carriers. Ann Intern Med. 1993; 118:191-4. Google Scholar2. Kiyosawa K, Yamamura N, Sodeyama T, Yoda H, Imai Y, Imai H, et al. Intrahepatic expression of HBsAg and HBcAg in asymptomatic HBsAg carriers and its follow-up. J Gastroenterol Hepatol. 1988; 3: 19-27. Google Scholar3. Kiyosawa K, Furuta S. Clinical aspect and epidemiology of hepatitis B and C viruses in hepatocellular carcinoma in Japan. Cancer Chemother Pharmacol. 1992; 31(Suppl):S150-6. Google Scholar Author, Article, and Disclosure InformationAffiliations: PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 15 September 1993Volume 119, Issue 6Page: 535KeywordsAntigensHepatitis BHepatitis B surface antigenHepatitis C virusHepatitis D virusHepatocellular carcinomaHistologyLiverLiver function testsRisk management Issue Published: 15 September 1993 Copyright & PermissionsCopyright © 1993 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Global fibrinolytic capacity in early respiratory distress syndrome: A pilot study
Authors: Murat Yurdakök, Ayse Korkmaz, Serafeddin Kirazlı, Canan Aygün, Sule Yigit
Journal: American Journal of Hematology (2002)

Fibrin deposits found in the pulmonary microcirculation and in the small airways of preterm infants with severe respiratory distress syndrome (RDS) has been explained by the activation of the coagulation system and/or insufficient fibrinolysis. Previous studies suggest that disseminated intravascular coagulation is not prominent in the early stages of RDS, and there is a reduced fibrinolytic activity in these patients. The in vitro evaluation of body's fibrinolytic potential is difficult in contrast to blood clotting because fibrinolysis is only activated after coagulation. To solve this problem a standardized assay was developed to measure the global fibrinolytic capacity (GFC) in plasma. This assay allows us a sensitive and reliable parameter to evaluate the fibrinolytic potency of plasma in vitro. We therefore studied GFC in the first 6 hr after birth in preterm infants who later developed RDS. Global fibrinolytic capacity which is expressed as generated D-dimer concentrations was significantly lower in preterm infants who later developed RDS compared to the control group in this study. These findings support our previous hypothesis of "reduced fibrinolytic state in early RDS".
Effect of Helicobacter pylori eradication on ulcer recurrence after simple closure of perforated duodenal ulcer
Authors: Ayman El-Nakeeb, Amir Fikry, Tito M. Abd El-Hamed, El Yamani Fouda, Saleh El Awady, Tamer Youssef, Doaa Sherief, Mohamed Farid
Journal: International Journal of Surgery (2008)
ETIOLOGIC STUDY OF A SERIES OF OPTIC NEUROPATHIES
Authors: ALAN C. WOODS
Journal: JAMA (1923)

In 1923, one of us with Dunn 1 reported an etiologic study of a series of various optic neuropathies. The patients reported in the former article had presented themselves at the clinic for visual disturbances, with no knowledge of the basic condition. There were eighty-six patients in this group, with various types of optic neuropathies. Of these eighty-six patients, thirty-five showed primary optic atrophy, twenty-four atrophy of the papillomacular bundles, thirteen secondary atrophy, five optic neuritis, four choked disk and five retrobulbar neuritis. Of these various conditions, 40 per cent were due to central nervous system syphilis, 12.7 per cent to disease of the posterior sinuses, 11.6 per cent to brain tumor, 5.8 per cent to multiple sclerosis, 11.6 per cent to toxic amblyopia, 3.5 per cent to various conditions, and in 13.8 per cent the actual cause of the optic neuropathy could not be determined.  Since the publication of
Penile, Testicular, Other Silicone Implants Soon Will Undergo FDA Review
Authors: Teri Randall
Journal: JAMA (1992)

THE SILICONE breast implant soon will share the spotlight with several other silicone devices to be investigated by the Food and Drug Administration (FDA) (<i>JAMA</i>. 1992;267:2439-2442). By year's end, manufacturers of the solid silicone penile and testicular implants and saline-filled breast implants (with a silicone shell) will be asked to provide the agency with data from rigorously conducted safety testing. Cerebral electrotherapy stimulators, used to treat severe depression, and cardiovascular bypass devices also will receive a call for data, says James Benson, director of the FDA's Center for Devices and Radiological Health. These five products, plus silicone gelfilled breast implants, are among 130 medical devices marketed before 1976. That was when Congress passed an amendment providing the FDA with the authority to regulate medical devices. Until recently, these "preamendment" devices and new devices based on them, even those with dramatic changes in design and materials, have escaped regulatory scrutiny. But
Peer Review as an Educational Challenge
Authors: James M. Schless
Journal: JAMA (1972)

Public perception of health care needs gives highest priority to spiraling costs with second place to the need for greater availability of health care services. Relatively far down on the list of public priorities is quality. The feeling is, by and large, that what we have is pretty good, and, if only we could afford it more easily and get it more readily, all would be fine. Peer review mechanisms have tended to follow public pressures and expectations and have largely concerned themselves with monitoring patterns of utilization and policing of individual instances of poor care. The problems of manpower and distribution are being approached by numerous proposals aimed at the production of more physicians and other health care personnel primarily to fill needed service roles. It is becoming increasingly evident that the rapid expansion of biomedical knowledge has created a "future shock" situation which demands increasing emphasis on the
ERUPTIVE TELANGIECTATIC CELLULAR NAEVI.
Authors: K. V. SANDERSON
Journal: British Journal of Dermatology (1960)

Journal Article ERUPTIVE TELANGIECTATIC CELLULAR NAEVI. Get access K. V. SANDERSON K. V. SANDERSON Adelaide, South Australia Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 72, Issue 8-9, 1 August 1960, Pages 302–307, https://doi.org/10.1111/j.1365-2133.1960.tb13898.x Published: 01 August 1960
Abstract 2097: In situ mutation detection in cancer tissue sections for research and diagnostics in clinical oncology
Authors: Ida Grundberg, Sara Kiflemariam, Juliana Imgenberg-Kreuz, Karolina Edlund, Patrick Micke, Magnus Sundström, Johan Botling, Mats Nilsson
Journal: Cancer Research (2012)

Abstract Activating oncogenic mutations are targets for a new generation of cancer drugs. Current mutation assays for clinical diagnostics are based on DNA-extracts from tissue sections that often contain morphologically heterogeneous neoplastic regions with variable mixtures of normal stromal and inflammatory cells. We have developed an RNA-based in situ mutation assay that can target oncogenic mutations in a multiplex fashion on tissue slides by the use of multiple mutation-specific padlock probes and rolling-circle amplification. For EGFR therapy prediction, we demonstrate reliable in situ detection of KRAS mutations in codon 12 and 13 in colon and lung cancer - on cytologic tumor imprints as well as on fresh frozen and formalin-fixed, paraffin-embedded tissue sections. High throughput screening of KRAS mutation status was successfully performed on a tissue microarray. Moreover, we show how the pattern of expressed mutated and wild-type alleles can be studied in situ from tumors with complex combinations of mutated EGFR, KRAS and TP53. This in situ method holds great promise as a tool to investigate the role of somatic mutations during tumor progression and for prediction of response to targeted therapy. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 103rd Annual Meeting of the American Association for Cancer Research; 2012 Mar 31-Apr 4; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2012;72(8 Suppl):Abstract nr 2097. doi:1538-7445.AM2012-2097
Acute Organophosphate Poisoning??? Tc-99m HMPAO SPECT Imaging of the Brain
Authors: ILKNUR G??NES, AYSUN YILMAZLAR, ISMET SARIKAYA, G??RAYTEN ??ZYURT
Journal: Clinical Nuclear Medicine (1994)

Two cases of organophosphate poisoning are presented along with Tc-99m HMPAO brain SPECT findings in the acute and delayed phases. Perfusion defects were more prominent at the onset of poisoning in both cases.
Acute Laryngotracheobronchitis Treated with 0.125% Superinone
Authors: M. Holmes-Siedle, T. N. Nauth-Misir
Journal: BMJ (1958)

<h3>Background</h3> Recovery from concussion sustained in childhood and adolescence is poorly understood. We explored patterns of recovery for neurocognition and postconcussive symptoms following concussion in children and adolescents. <h3>Methods</h3> Using a prospective, longitudinal design, we collected baseline data on 728 children and adolescents aged 10–17 years. 10 participants sustained a concussive injury (n=10) in the 12 months following baseline testing and they were reviewed at day 5, 10 and 30 postconcussion. Assessments included the CogSport for Kids computerised test battery to evaluate neurocognitive function and self-report, and parent measures of postconcussive symptoms. At day 30, parents also completed measures rating their child9s quality of life and executive functions. <h3>Results</h3> Children and adolescents displayed a gradual reduction in postconcussive symptoms over the 30 days following injury. At day 5, 87% of participants were reporting physical and cognitive symptoms, with a generalised reduction in all symptoms by day 10 (40% of participants). On the computerised measure, reaction time was slower after concussion, but returned to baseline levels by day 30. At day 30, 10% of participants demonstrated ongoing postconcussive symptoms. Number of previous concussions was related to speed of symptom resolution. <h3>Conclusions</h3> At 5 days postconcussion, the majority of children and adolescents experienced debilitating postconcussive symptoms. However, by 30 days postinjury, 90% demonstrated recovery to normal for both neurocognition and postconcussive symptoms.
Alphée Cazenave and Lupus Erythematosus
Authors: Hendrik M. G. Doeglas
Journal: JAMA (1964)

<h3>To the Editor:—</h3> I read with interest your editorial on Cazenave (<i>JAMA</i><b>185</b>:1038 [Sept 28] 1963), in which you mention that the expression "lupus erythematosus" first appeared in the literature in the<i>Annales des Maladies de la Peau et de la Syphilis</i>of 1851. Actually, in the library of the University of Leiden there is a publication issued one year before that date which describes a clinical conference held by Cazenave, in which he uses the expression lupus erythematosus and gives a vivid description of the disorder. The paper, "Formes du lupus et son traitement," appeared in the<i>Lancette française, Gazette des Hôpitaux</i>(<b>23</b>:354 [July] 1850). The paper, apparently written by someone who attended the demonstration, was signed only with the letter Z. After discussing Biett's three types of lupus, Cazenave added a variety "which is rather rare and until now incompletely described and wrongly classified." Biett had
Death certification and epidemiological research
Authors: D M Parkin
Journal: BMJ (1978)

discrepancies turn out to be mainly aberrations which are correctable in their wider context.Over the years death certification has improved with advances in medicine.More information is given and it is more precise.We should tackle administrative weaknesses such as failure of pathologists to state explicitly causes of death, failure to update after necropsy, and relegation of completion to junior doctors without instruction.Over the past 140 years these records (the results of everyday experience of doctors) have contributed a great deal to our knowledge of the health of the nation and to medical research.Of course, there is a continuous need to study their flaws -especially as part of practical research-as was done in the papers by the study group of the Royal College of Physicians.I trust that these papers will be read constructively, otherwise they may have a negative effect, the best becoming the enemy of the good.
SAFETY AND EFFICACY ASSESSMENT OF INTRACORONARY DELIVERY OF PORCINE CARDIAC STEM CELLS IN A SWINE MODEL OF ACUTE MYOCARDIAL INFARCTION: COMPARISON OF TWO DIFFERENT CELL DOSES
Authors: Claudia Baez-Diaz, Veronica Crisostomo, Juan Maestre, Monica Garcia-Lindo, Fei Sun, Javier G Casado, Itziar Palacios, Virginia Nunes, Francisco Miguel Sanchez-Margallo
Journal: Journal of the American College of Cardiology (2014)
Undersized Mitral Annuloplasty Alters Left Ventricular Shape During Acute Ischemic Mitral Regurgitation
Authors: Frederick A. Tibayan, Filiberto Rodriguez, Frank Langer, David Liang, George T. Daughters, Neil B. Ingels, D. Craig Miller
Journal: Circulation (2004)

Underlying left ventricular (LV) dysfunction contributes to poor survival after operation to correct ischemic mitral regurgitation (IMR). Many surgeons do not appreciate that a key component of the Bolling undersized mitral ring annuloplasty concept is to decrease LV wall stress by altering LV shape, but precise 3-dimensional (3-D) geometric data do not exist substantiating this effect. We tested the hypothesis that annular reduction decreases regional circumferential LV radius of curvature (ROC) in a model of acute IMR.Eight adult sheep underwent insertion of an adjustable Paneth-type annuloplasty suture and radiopaque markers on the LV and mitral annulus. The animals were studied with biplane videofluoroscopy during baseline conditions, then before and after tightening the annuloplasty suture during proximal left circumflex occlusion. End-systolic circumferential regional LV ROC and mitral annular area were computed.Acute IMR was eliminated (MR grade 2.1+/-0.4 to 0.4+/-0.4, mean+/-SD, P<0.05) by tightening the Paneth annuloplasty suture. Paneth suture tightening during circumflex occlusion also decreased end-systolic regional circumferential radii of curvature at the basal (anterior, 3.40+/-0.16 to 3.34+/-0.14 cm; posterior, 3.31+/-0.23 to 3.24+/-0.26 cm; P<0.05) and equatorial levels (anterior, 2.99+/-0.21 to 2.89+/-0.29 cm; posterior, 2.86+/-0.38 to 2.81+/-0.41 cm; P<0.05).Acute proximal circumflex occlusion caused IMR and increased end-systolic LV radii of curvature in this experimental preparation. Annular reduction sufficient to abolish IMR also decreased end-systolic anterior and posterior LV ROC, which would be expected to reduce LV wall stress and oxygen consumption in these regions, both potentially beneficial effects. The long-term effects of undersized annuloplasty on LV remodeling and function, however, will require further study in chronic animal preparations or patients with chronic IMR.