tbuckley/cabot-search huggingface dataset:
Outcome of treatment with azathioprine in severe atopic dermatitis: a 5-year retrospective study of adult outpatients
Authors: S.F. Thomsen, T. Karlsmark, K.K.B. Clemmensen, C. Graversgaard, K.S. Ibler, G.B.E. Jemec, T. Agner
Journal: British Journal of Dermatology (2014)

Journal Article Outcome of treatment with azathioprine in severe atopic dermatitis: a 5‐year retrospective study of adult outpatients Get access S.F. Thomsen, S.F. Thomsen Department of Dermatology Bispebjerg Hospital University of Copenhagen Copenhagen Denmark Search for other works by this author on: Oxford Academic Google Scholar T. Karlsmark, T. Karlsmark Department of Dermatology Bispebjerg Hospital University of Copenhagen Copenhagen Denmark Search for other works by this author on: Oxford Academic Google Scholar K.K.B. Clemmensen, K.K.B. Clemmensen Department of Dermatology Bispebjerg Hospital University of Copenhagen Copenhagen Denmark Search for other works by this author on: Oxford Academic Google Scholar C. Graversgaard, C. Graversgaard Department of Dermatology Roskilde Hospital University of Copenhagen Roskilde Denmark Search for other works by this author on: Oxford Academic Google Scholar K.S. Ibler, K.S. Ibler Department of Dermatology Roskilde Hospital University of Copenhagen Roskilde Denmark Search for other works by this author on: Oxford Academic Google Scholar G.B.E. Jemec, G.B.E. Jemec Department of Dermatology Roskilde Hospital University of Copenhagen Roskilde Denmark Search for other works by this author on: Oxford Academic Google Scholar T. Agner T. Agner Department of Dermatology Bispebjerg Hospital University of Copenhagen Copenhagen Denmark Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 172, Issue 4, 1 April 2015, Pages 1122–1124, https://doi.org/10.1111/bjd.13495 Published: 01 April 2015
Role of TNFRSF13B variants in patients with common variable immunodeficiency
Authors: Natalia Martínez-Pomar, Drahomíra Detková, Juan I. Arostegui, Antonio Alvarez, Pere Soler-Palacín, Antonio Vidaller, Teresa Espanol, Almudena Sampalo, Javier de Gracia, Manuel Hernandez, Jordi Yagüe, Nuria Matamoros
Journal: Blood (2009)
Comment: Male Breast Cancer
Authors: Philip Rubin
Journal: JAMA (1967)

The management of cancer of the male breast presents some interesting contrasts to female breast carcinoma. The relative infrequency of male breast cancer, usually quoted as less than 1% of all breast cancer, is a function of the small amount of mammarian gland tissue in men. The largest, carefully analyzed experience is Treves and Holleb's<sup>38</sup>report of 146 cases. General facts worthy of note are that the average age of incidence is 52 years in a range from 24 to 85 years and that the disease is predominant in white men, foreign-born men, and those of Jewish extraction. The detection of a mass in 90% of the patients on presentation would be anticipated with the small amount of adipose tissue in the male breast. Nipple changes occurred in 51% of the cases and a bloody discharge, though encountered in only 16%, was diagnostic of breast cancer if it was
Care for "Environmental Illness"
Authors: Howard Frumkin
Journal: Annals of Internal Medicine (1989)

Letters and Corrections15 September 1989Care for "Environmental Illness"Howard Frumkin, MD, MPHHoward Frumkin, MD, MPHSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-111-6-542_1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the Editor: The position paper (1) and accompanying editorial (2) on clinical ecology were timely, thoughtful, and balanced. As a practitioner of occupational and environmental medicine, I am referred a fair number of patients who carry the diagnosis of "environmental illness." Many have already seen several physicians and can relate an odyssey of diagnostic and therapeutic adventures.In addition to the diagnostic measures described in the position paper, many of my patients have undergone assays of various body compartments—blood, urine, hair, and fat—for substances such as volatile organics, hydrocarbons, pesticides, and metals. Many dozens of tests are usually done...References1. . Clinical ecology. Ann Intern Med. 1989;111:168-78. LinkGoogle Scholar2. KahnLetz EG. Clinical ecology: environmental medicine or unsubstantiated theory? Ann Intern Med. 1989;111:104-6. LinkGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Hospital of the University of Pennsylvania Philadelphia, PA 19104 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByNEGLIGENT HIRING AND DEFAMATION: AREAS OF LIABILITY RELATED TO PRE-EMPLOYMENT INQUIRIES 15 September 1989Volume 111, Issue 6Page: 542-542KeywordsEcologyHydrocarbonsUrine Issue Published: 15 September 1989 PDF DownloadLoading ...
Asthma symptoms and nasal congestion as independent risk factors for insomnia in a general population: results from the <scp>GA</scp><sup>2</sup><scp>LEN</scp> survey
Authors: F. Sundbom, E. Lindberg, A. Bjerg, B. Forsberg, K. Franklin, M. Gunnbjörnsdottir, R. Middelveld, K. Torén, C. Janson
Journal: Allergy (2012)

Abstract Background Asthma and rhinitis have been related to insomnia. The aim of this study was to further analyse the association between asthma, nasal symptoms and insomnia and to identify risk factors for sleep disturbance among patients with asthma, in a large population‐based set of material. Method In 2008, a postal questionnaire was sent to a random sample of 45 000 adults in four Swedish cities. The questionnaire included questions on insomnia, asthma, rhinitis, weight, height, tobacco use and physical activity. Results Twenty‐five thousand six hundred and ten subjects participated. Asthma was defined as either current medication for asthma or at least one attack of asthma during the last 12 months, and 1830 subjects (7.15%) were defined as asthmatics. The prevalence of insomnia symptoms was significantly higher among asthmatics than non‐asthmatics (47.3% vs 37.2%, &lt;0.0001). In the subgroup reporting both asthma and nasal congestion, 55.8% had insomnia symptoms compared with 35.3% in subjects without both asthma and nasal congestion. The risk of insomnia increased with the severity of asthma, and the adjusted OR for insomnia was 2.65 in asthmatics with three symptoms compared with asthmatics without symptoms. Nasal congestion ( OR 1.50), obesity ( OR 1.54) and smoking ( OR 1.71) also increased the risk of insomnia. Conclusion Insomnia remains a common problem among asthmatics. Uncontrolled asthma and nasal congestion are important, treatable risk factors for insomnia. Lifestyle factors, such as smoking and obesity, are also risk factors for insomnia among asthmatics.
Differentiation and functional regulation of human fetal NK cells
Authors: Martin A. Ivarsson, Liyen Loh, Nicole Marquardt, Eliisa Kekäläinen, Lena Berglin, Niklas K. Björkström, Magnus Westgren, Douglas F. Nixon, Jakob Michaëlsson
Journal: Journal of Clinical Investigation (2013)

The human fetal immune system is naturally exposed to maternal allogeneic cells, maternal antibodies, and pathogens. As such, it is faced with a considerable challenge with respect to the balance between immune reactivity and tolerance. Here, we show that fetal natural killer (NK) cells differentiate early in utero and are highly responsive to cytokines and antibody-mediated stimulation but respond poorly to HLA class I–negative target cells. Strikingly, expression of killer-cell immunoglobulin-like receptors (KIRs) did not educate fetal NK cells but rendered them hyporesponsive to target cells lacking HLA class I. In addition, fetal NK cells were highly susceptible to TGF-β–mediated suppression, and blocking of TGF-β signaling enhanced fetal NK cell responses to target cells. Our data demonstrate that KIR-mediated hyporesponsiveness and TGF-β–mediated suppression are major factors determining human fetal NK cell hyporesponsiveness to HLA class I–negative target cells and provide a potential mechanism for fetal-maternal tolerance in utero. Finally, our results provide a basis for understanding the role of fetal NK cells in pregnancy complications in which NK cells could be involved, for example, during in utero infections and anti-RhD–induced fetal anemia.
Debate about Funding Comparative-Effectiveness Research
Authors: Jerry Avorn
Journal: New England Journal of Medicine (2009)

The proposal to include $1.1 billion for comparative-effectiveness research (CER) in the federal stimulus package encountered a vigorous and well-coordinated backlash. The campaign to gut this funding ultimately failed, but the debate it engendered and the resonance of the opposition's arguments in both lay and policy circles reveal much about the issues that will surround such research and its application in the coming years.The contested provisions were designed to support studies comparing the efficacy and safety (and, by extension, the cost-effectiveness) of alternative ways of addressing common clinical problems. Interventions to be evaluated will include pharmaceuticals, devices, procedures, and . . .
Abstract 399: A special childhood T-ALL model of NOD/SCID mice can recapitulate the clinical patient disease
Authors: Amy Zhang, Liang Huang, Shuyan Ma, Na Wang, Jingping Liu, Xiaoming Song, Taiping Chen, Jean-Pierre Wery, Yiyou Chen, Jianfeng Zhou, Pengfei Zhou
Journal: Cancer Research (2010)

Abstract Despite recent advances in the management of childhood acute lymphoblastic leukemia (ALL), the risk of relapse remains about 30 percent. Here we report an interesting childhood T-acute lymphoblastic leukemia (T-ALL) patient case, engrafting into NOD/SCID mice successfully, recaptured the clinical course accurately including the rapid remission induction, minimal residual disease and relapsing. Immunophenotypes of primary, secondary and third xenografts indicated the cells expressing CD3/CD5/CD7/CD4, as well as the genetic lesions, were unaltered compared with the original patient sample. Immunohistochemistry (IHC) studies showed more than 90% infiltration of leukemic cells in spleen, liver, lung and variable level in other organs include brain within 4 weeks in primary xenografts and 2 weeks in secondary xenografts. The response to Vinscristine and Dexamesathone of primary engrafts was similar to what the original patient did in the clinic. A minimal residual disease phase and relapsing model had also been established in this model after complete remission induced by Vincristine plus Dexamesathone. In addition, Dexamesathone treatment alone was able to prolong the survival of the T-ALL hosts for more than two weeks in the presence of over 90% cancer cell infiltration in the peripheral blood. This study supports previous finding that the NOD/SCID model of childhood T-ALL is an accurate representation of the patient disease and can be used in the screening of anticancer drugs for childhood ALL. This model also warrants further investigation in T-ALL at relapse and potentially in the study of minimal residual disease for chemotherapy-resistant T-ALL subgroups. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 101st Annual Meeting of the American Association for Cancer Research; 2010 Apr 17-21; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2010;70(8 Suppl):Abstract nr 399.
Influence of Maternal Allergen Exposure in the Development of Allergic Airway Disease in the Offspring: Effects of Antigen and Timing of Exposure
Authors: J. Yang, K. Gabehart, K.A. Correll, A. George, M.L. Collins, E.W. Gelfand, A. Dakhama
Journal: Journal of Allergy and Clinical Immunology (2012)
Abstract 1070: Pancreatic Ductal Adenocarcinoma (PDA) mice lacking Mucin 1 has a profound defect in tumor growth and metastasis
Authors: Dahlia Besmer, Lopamudra Das Roy, Jennifer Curry, Teresa Tinder, Mahnaz Manouchehrabadi, Jorge Schettini, Sunil Hwang, Yong-Yook Lee, Sandra Gendler, Pinku Mukherjee
Journal: Cancer Research (2011)

Abstract MUC1 is over expressed and aberrantly glycosolated in &amp;gt;60% of pancreatic ductal adenocarcinomas. Over expression of MUC1 in pancreatic cancer is known, however the functional role has yet to be fully elucidated due to a dearth of appropriate models. In the present study, we have generated mouse models that spontaneously develop pancreatic ductal adenocarcinoma (KC), which are either Muc1 null (KCKO) or express human MUC1 as a self antigen (KCM). We show that PDA mice lacking Muc1 have significantly slower tumor progression, with tumor weight reaching up to a third of the KCM tumor and half of KC tumor. One out of 10 KCKO mice developed secondary metastasis versus 6 out of 10 and 3 out of 10 KCM and KC respectively. Cell lines derived from KCKO tumors have significantly lower tumorigenic capacity compared to cells derived from KCM tumors. Therefore, mice with KCKO tumors had a significant survival benefit compared to mice bearing the KCM tumors. In vitro, the KCKO cells have reduced proliferation and invasion compared to KCM cells and failed to respond to exogenous epidermal growth factor (EGF), platelet-derived growth factor (PDGF), or matrix metalloproteinase-9 (MMP9) stimuli. Further, significantly fewer KCKO cells entered the G2M phase of the cell cycle compared to the KCM cells, consequently more KCKO cells were observed at the S-phase of the cell cycle. Proteomics and western blotting analysis revealed a complete loss of cdc-25c expression, phosphorylation of MAPK, as well as a significant decrease in Nestin and Tubulin α-2 chain expression in KCKO cells. Treatment of the KCM cells with a MEK1/2 inhibitor, U0126, completely abrogated the enhanced proliferation of the KCM cells but had minimal effect on KCKO cells, strongly suggesting that MUC1 is necessary for MAPK activity and downstream oncogenic signaling. This is the first study to utilize a Muc1-null PDA mouse in order to fully elucidate the oncogenic role of MUC1, both in vivo and in vitro. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 102nd Annual Meeting of the American Association for Cancer Research; 2011 Apr 2-6; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2011;71(8 Suppl):Abstract nr 1070. doi:10.1158/1538-7445.AM2011-1070
Importance of Budgeting Neurological Research Grants
Authors: John R. Green
Journal: JAMA (1970)

<h3>To the Editor:—</h3> The Federation of Western Societies of Neurological Science (FWSNS), consisting of eight component groups, representing most of the neuroscientists in the Western States, at its annual meeting in Phoenix, Ariz, March 5 to 8, has recognized that federal support through the National Institute of Neurological Disease and Stroke (NINDS) for teaching and research in neurosciences has been a major factor in improving the prevention and treatment of neurological disorders during the last 25 years. The FWSNS realizes that to maintain the momentum of these programs of research requires a continuation of this support. The FWSNS also recognizes that any reduction of support for training inevitably commits this nation to a long-term reduction in research effort in the neurosciences. Any reduction of support to this area seems unthinkable in view of the central position of the nervous system in all aspects of health and the obvious social impact
Pancreatic Islet Cell Carcinoma
Authors: Lawrence E. Broder, Stephen K. Carter
Journal: Annals of Internal Medicine (1973)

The clinical features of 52 patients with metastatic pancreatic islet cell carcinoma treated with streptozotocin (NSC-85998) were analyzed. Seventy-nine percent of the patients had functioning tumors, with the majority secreting insulin; 21% of the patients had nonfunctioning tumors. The tumors were found primarily in the tail of the pancreas and were noted with equal frequency in men and women, at a median age of 52 years. Metastases were mainly to the liver and by local extension; distant metastases were rarely noted. The most frequently reported presenting symptom was hypoglycemia, occurring in 90% of the functioning-tumor patients. Gastrointestinal ulceration and diarrhea were less frequently observed. An overall median survival of 908 days, from diagnosis to last follow-up, was noted. There was no significant difference in survival rates between the sexes or between the functioning- as compared to the nonfunctioning-tumor patients.
ORAL CIPROFLOXACIN THERAPY OF INFECTIONS DUE TO PSEUDOMONAS AERUGINOSA
Authors: BrianE. Scully, MichaelF. Parry, HaroldC. Neu, William Mandell
Journal: The Lancet (1986)

The efficacy and safety of oral ciprofloxacin, a fluoroquinolone, were evaluated in the treatment of infection due to Pseudomonas aeruginosa. 96 infections in 71 patients were treated. Substantial underlying disease was present in most of the patients, and 25 (35%) were seriously ill. 52% of pseudomonas isolates were carbenicillinresistant, and 31% gentamicin-resistant. The overall clinical response rate was 77% - 28 of 35 exacerbations of cystic fibrosis respiratory disease, 17 of 19 urinary infections, 4 of 6 osteomyelitis, and 11 of 15 soft tissue infections. The bacteriological cure rate was 34% - 0 of 35 cystic fibrosis, 4 of 17 respiratory infections, 17 of 19 urinary infections, 4 of 6 osteomyelitis, and 8 of 15 soft tissue infections. Ps aeruginosadeveloped resistance to ciprofloxacin in 25 of 96 infections. Side-effects were generally slight with nausea in 14 (15%) the most common, and there were only two substantial superinfections.
The antitumor function of tumor necrosis factor (TNF), I. Therapeutic action of TNF against an established murine sarcoma is indirect, immunologically dependent, and limited by severe toxicity.
Authors: E A Havell, W Fiers, R J North
Journal: The Journal of Experimental Medicine (1988)

The ability of murine recombinant tumor necrosis factor (rTNF) and natural TNF in tumor-necrotizing serum (TNS) to cause regression of the SA1 sarcoma was investigated. We found that to cause regression of a 9-d SA1 sarcoma, near lethal quantities of rTNF and TNS had to be given to the host. However, even at these highly toxic doses, rTNF was not reliable at causing complete tumor regression. On the other hand, both types of TNF were reliable at causing a tumor hemorrhagic reaction that resulted in the destruction of greater than 75% of the tumor's center in 24 h. The TNF-induced hemorrhagic reaction involved the development of numerous petechial hemorrhages in the tumor's vascular bed, which apparently resulted from destruction of the tumor's blood vessels. It was possible to follow the development of the hemorrhagic reaction against time after giving rTNF or TNS by measuring the intratumor extravasation of 51Cr-labeled syngeneic red cells. According to this method, TNF-induced intratumor hemorrhaging was in progress within 1 h of giving TNF and continued for about a 6-h period. However, the hemorrhagic reaction was greatly reduced and complete regression of the rim of the living tumor tissue that survived hemorrhagic necrosis failed to occur, if SA1 sarcoma was growing in T cell-deficient (TXB) mice. This indicates that the TNF-induced hemorrhagic reaction is partly dependent, and the tumor regression that follows is completely dependent on host immunocompetence. This suggests in turn, that rTNF does not directly destroy SA1 tumor cells in vivo, even though it was shown that it can destroy SA1 tumor cells in vitro. This interpretation is supported by the additional findings that rTNF was no more therapeutic against a 3-d (3-mm) SA1 than against a 9-d (8-mm) SA1, and was no more therapeutic when injected directly into the tumor than when injected intravenously. Lastly it was possible to completely inhibit the ability of rTNF and TNS to cause tumor hemorrhagic necrosis and regression by infusing the host with a monospecific, polyvalent anti-rTNF antibody that neutralized the cytotoxic action of rTNF in vitro.
Group Drinking During Stress: Effects on Drinking Behavior, Affect, and Psychopathology
Authors: LAWRENCE R. ALLMAN, H. AUGUSTUS TAYLOR, PETER E. NATHAN
Journal: American Journal of Psychiatry (1972)

Three chronic alcoholics took part in a 32-day study in which relationships between experimentally imposed stress and alcohol consumption, mood, and psychopathology were explored. Subjects drank most when stress and socialization periods coincided; they drank least when stress and periods of isolation occurred together. Stress produced significant increases in tension, depression, and anger, while alcohol independently increased prevailing levels of depression and anxiety. The relevance of these findings to questions of etiology and treatment is discussed.
Medical Grand Rounds at Hopkins
Authors: John D. Stobo
Journal: JAMA (1989)

With this issue,The Journalcommences publication of selected case discussions from medical grand rounds at The Johns Hopkins Hospital, Baltimore, Md.<sup>1</sup>Case discussions as a form of teaching began with William Osier and have continued at Hopkins.<sup>2</sup>Osler performed rounds in the clinic on patients he had never seen before; he took a history and did a physical examination on the spot, and he said whatever he wished about them, drawing on his immense personal experience and his encyclopedic knowledge of the literature in three languages. Usually what Osier had to say was remarkably shrewd. Of course, he was in a somewhat privileged position: if Osler said the diagnosis was typhoid, no intern was going to quibble about the negative Widal's reaction. With time, people who could discuss anything at a moment's notice became scarce, and rounds changed. The venue was moved from the clinic to an
Saskatchewan Medical Care Scheme
Authors: G. M. Wyant
Journal: BMJ (1964)

SIR,-As much as one would like to avoid a public controversy of the medico-political events in another part of the world one can- not let go unchallenged Lord Taylor's re- marks in your columns (18 January, p. 178).Lord Taylor regrets the split in the medical profession in this province between those who wish to practise medicine without Govern- ment interference and those working in com- munity health clinics.What he omits entirely to say is that only about 10% of physicians in community clinics are either Canadians or individuals who by virtue of having lived in Canada for a number of years have become part of the professional life of this country and province.The great majority of physi- cians practising in these clinics have been im- ports to Canada since the crisis of July 1962.
Mandell, Douglas, and Bennett's Principles and Practice of Infectious Diseases
Authors: Jerry D. Smilack
Journal: JAMA (1995)

Since its publication in 1979,<i>Principles and Practice of Infectious Diseases</i>(PPID) has become an essential element of every medical library. Infectious diseases clinicians have well-worn home or office copies to which they repeatedly turn. Other less complete infectious diseases texts have come and gone, but with each revision PPID remains the standard. The latest edition, a beautifully packaged two-volume opus of nearly 3000 pages, raises the measure of excellence to a new level. How does one review a book of this size? Clearly, reading every word (an estimated 2½ million words of text, not counting tens of thousands in the extensive literature citations) in each of the 302 chapters is nearly impossible. Even if one could read technical material at a breakneck and nonstop pace of 300 words per minute, over 140 hours, or more than two weeks of eight-hour days (including weekends), would be required! Lacking the luxury,
Large vessel disease in CREST.
Authors: J J Belch, D J Veale, T Colleridge
Journal: Annals of the Rheumatic Diseases (1993)

Doctors such as ourselves who have treated individual patients and performed research on representative samples have been thought to have inadequate explanations for epi- demiological phenomena.Unfortunately, in Australia there have been no concerted national mechanisms implemented with a view to resolving these important issues.Perhaps that is the most important lesson to be learnt.