EFFECTIVENESS OF N-ALLYLNORMORPHINE IN THE MANAGEMENT OF ACUTE MORPHINE POISONING
Authors: Francis J. Marx, Julian Love
Journal: Annals of Internal Medicine (1953)

Case Reports1 September 1953EFFECTIVENESS OF N-ALLYLNORMORPHINE IN THE MANAGEMENT OF ACUTE MORPHINE POISONINGFRANCIS J. MARX, M.D., JULIAN LOVE, M.D., F.A.C.P.FRANCIS J. MARX, M.D.Search for more papers by this author, JULIAN LOVE, M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-39-3-635 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe clinician of yesterday regarded morphine as the most valuable drug of his entire therapeutic armamentarium. Although it has been relegated to a less exalted spot and forced to share its value as a pain reliever by the newer synthetic narcotics, such as meperidine and methadone, it remains a highly useful and often employed medication. Hence the advent of an effective antidote, N-allylnormorphine (Nalline) is of signal importance. All physicians should become familiar with the pharmacology, dosage and method of employment of such a preparation, and it should be made readily available in all antidote kits and wherever morphine and...Bibliography1. Beecher HK: Misuse of morphine sulfate as a therapeutic agent, Surg., Gynec. and Obst. 81: 461-462, 1945. Google Scholar2. JeghersBrick HIB: Hazards in the therapeutic use of morphine, M. Clin. North America 33: 1761-1775, 1950. CrossrefGoogle Scholar3. GoodmanGillman LA: The pharmacological basis of therapeutics, 1941, The Macmillan Company, New York, pp. 209-211. Google Scholar4. von BraunKruberAust JOE: Morphine alkaloid, Ber. d. deutsch. chem. Gesellsch. 47: 2312, 1914. Google Scholar5. McCawleyHartMarsh ELERDF: The preparation of N-allylnormorphine, J. Am. Chem. Soc. 63: 314, 1941. CrossrefGoogle Scholar6. Hart ER: Further observation on the antagonistic actions of N-allylnormorphine against morphine, Federation Proc. 2: 83, 1943. Google Scholar7. Unna K: Antagonistic effect of N-allylnormorphine upon morphine, J. Pharmacol. and Exper. Therap. 79: 27-31 (Sept.) 1943. Google Scholar8. HartMcCawley EREL: Pharmacology of N-allylnormorphine as compared with morphine, J. Pharmacol. and Exper. Therap. 82: 339-348 (Dec.) 1944. Google Scholar9. SmithLehmanGilfillan CCEGJL: Antagonistic action of N-allylnormorphine upon the analgetic and toxic effects of morphine, methadone derivatives and isonipecaine, Federation Proc. 10: 335-336 (Mar.) 1951. Google Scholar10. HugginsGlassBryan RAWGAR: Protective action of N-allylnormorphine against respiratory depression produced by some compounds, related to morphine, Proc. Soc. Exper. Biol. and Med. 75: 540-541 (Nov.) 1950. CrossrefMedlineGoogle Scholar11. EckenhoffElderKing JEJDBD: The effect of N-allylnormorphine in treatment of opiate overdose, Am. J. M. Sc. 222: 115 (July) 1951. Google Scholar12. EckenhoffHoffmanDripps JEGLRD: N-allylnormorphine: an antagonist to the opiates, Anesthesiology 13: 242-251 (May) 1952. CrossrefMedlineGoogle Scholar13. EckenhoffElderKing JEJDBD: N-allylnormorphine in the treatment of morphine or Demerol narcosis, Am. J. M. Sc. 223: 191-197 (Feb.) 1952. CrossrefMedlineGoogle Scholar14. Wikler A: Effects of large doses of N-allylnormorphine on man, Federation Proc. 10: 345 (Mar.) 1951. Google Scholar15. ChaseBoydAndrews HFRSPM: N-allylnormorphine in treatment of dihydromorphinone and methorphinan overdosage; report of a case, J. A. M. A. 150: 1103-1104 (Nov. 15) 1952. CrossrefMedlineGoogle Scholar16. FraserWiklerEisenmanIsbell HFAAJH: Use of N-allylnormorphine in the treatment of methadone poisoning in man. Report of two cases, J. A. M. A. 148: 1205-1207 (Apr. 5) 1952. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: *Received for publication March 18, 1953.All opinions expressed herein are those of the authors and do not necessarily reflect the official views of the U. S. Navy Department or the Bureau of Medicine and Surgery. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byThe Human Pharmacology and Clinical Use of Narcotic AntagonistsN-allylnormorphine (nalline) action on narcotized and non-narcotized subjects 1 September 1953Volume 39, Issue 3Page: 635-640KeywordsAntidotesDrugsMorphinePharmacologySurgery ePublished: 1 December 2008 Issue Published: 1 September 1953 PDF downloadLoading ...