tbuckley/cabot-search huggingface dataset:
Factors influencing the development of serum precipitins to farmer's lung antigen in Quebec dairy farmers.
Authors: Y Cormier, J Belanger, P Durand
Journal: Thorax (1985)

A total of 888 randomly selected dairy farmers participated in an epidemiological study to evaluate the prevalence of precipitins to farmer9s lung antigens, and the socioeconomic factors associated with their presence. Precipitins were present in 75 farmers (8.4%) (65 to Micropolyspora faeni, seven to Aspergillus spp, two to both Aspergillus and Micropolyspora faeni, and one to Aspergillus and Thermoactinomyces vulgaris). The titres ranged from a dilution of 1/32 to a concentration of X 2 (Ouchterlony9s double diffusion method). In the study population there were 544 who had never smoked, 146 ex-smokers, and 198 smokers. Sixty nine precipitin positive subjects were either never smokers or ex-smokers; only six were smokers. The negative relationship between cigarette smoking and precipitins was highly significant (p = 0.004). Factors positively associated with positive precipitin reactions were: size of farm, time spent in the barn, and the presence of a family member previously diagnosed as having farmer9s lung disease. Interestingly, positive precipitin reactions were not associated with any of the following: use of silos, hay conditioners, or hay dryers; the presence or quantity of mouldy hay; or the presence of respiratory symptoms. It is concluded that precipitin analysis is not useful as a screening method for farmer9s lung, though it can be of diagnostic value in acute farmer9s lung disease.
In vitro and in vivo effects of ribavirin on human respiratory epithelium.
Authors: L Y Han, R Wilson, S Slater, A Rutman, R C Read, N J Snell, P J Cole
Journal: Thorax (1990)

The effects of ribavirin, a broad spectrum antiviral agent, on the structure and function of normal human nasal epithelium have been studied in vitro, as has also the in vivo effect of treatment with nebulised ribavirin on nasal mucociliary clearance of saccharin in four patients. Ciliary beat frequency was measured by a photometric technique, and changes in epithelial and ciliary ultrastructure were assessed by transmission electron microscopy. Ribavirin solution at the recommended concentration of 20 mg/ml had no adverse effects on ciliary activity in vitro; at concentrations of 50 mg/ml and above it slowed ciliary beating significantly and at 60 mg/ml caused ciliostasis associated with epithelial disruption. Nasal inhalation of ribavirin at 60 mg/ml for up to 20 minutes, however, did not slow nasal mucociliary clearance, nor did it adversely affect the ciliary beating or structure of nasal ciliated epithelium examined in vitro immediately after inhalation.
Emphysema, cirrhosis, and heart block in a young patient with partial alpha 1 antitrypsin deficiency (PiMZ phenotype).
Authors: C F McDonald, P M Stewart, G Blundell, G K Crompton
Journal: BMJ (1985)

Severe lung disease and liver disease are not recognised features of the PiMZ phenotype, which is associated with alpha 1 antitrypsin deficiency. A 31 year old woman with this phenotype was found to have emphysema and complete heart block and showed evidence of hepatic cirrhosis, although her three sisters, all of whom had the same phenotype, were clinically normal. This case supports the possibility of a causal relation between the PiMZ phenotype and chronic lung and liver disease, but an association between alpha 1 antitrypsin deficiency and complete heart block could not be proved in this patient.
Inability of the Submaximal Treadmill Stress Test to Predict the Location of Coronary Disease
Authors: MARVIN A. KAPLAN, CLIFFORD N. HARRIS, WILBERT S. ARONOW, DAVID P. PARKER, MYRVIN H. ELLESTAD
Journal: Circulation (1973)

Two hundred patients had submaximal treadmill stress tests (STSTs) and selective coronary arteriography performed within 2 months of each other. An attempt was made to assess the predictability of disease isolated to any given coronary vessel by performance on the treadmill. This was not possible for disease isolated to the right coronary, the left anterior descending, the circumflex branch of the left coronary, or a combination of right coronary and circumflex arteries. Eleven patients had disease in the left main coronary artery; all had associated disease of some other branch as well. One of these patients had a negative submaximal treadmill stress test but was unable to reach 90% of his maximum predicted heart rate. The remaining 10 patients had positive STSTs. Patients with 26-50% narrowing of any branch had treadmill results similar to those with 51-75% narrowing. There was a large number of patients with single-vessel disease in the study and most of the negative STSTs occurred in this group. Nevertheless, within this group no one vessel gave a higher incidence of positive STSTs than any other. It is concluded that (1) a positive STST is more likely to be associated with increased severity and extent of coronary artery disease; (2) a negative STST is more likely to be found in disease limited to a single vessel; and (3) within the latter group, the STST is of no value in predicting the specific coronary artery involved.
MOSES MAIMONIDES AND PSYCHOSOMATIC MEDICINE
Authors: FRED ROSNER
Journal: Annals of Internal Medicine (1968)

Letters and Comments1 February 1968MOSES MAIMONIDES AND PSYCHOSOMATIC MEDICINEFRED ROSNER, M.D.FRED ROSNER, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-68-2-493 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the Editor: It was with great interest that I read the historical review of the "Physiological Basis for Psychosomatic Medicine" by Kollar and Alcalay in the October 1967 issue of the ANNALS. Although Galen, Vesalius, Harvey, and Morgagni, among others, are discussed, one prolific medieval writer in this field, namely Moses Maimonides, is not mentioned.Maimonides wrote ten medical treatises including his famousAphorisms, Discourses on Asthma, Poisons, Hemorrhoids, Hygiene, Drugs, Extracts from Galen, andCommentary on the Aphorisms of Hippocrates. The second half of Chapter 3 of Maimonides'Treatise on Hygiene, composed for Sultan Al Afdal, son of... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Maimonides Medical Center Brooklyn, N. Y. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 February 1968Volume 68, Issue 2Page: 493-494KeywordsAsthmaDrugsHygiene Issue Published: 1 February 1968 PDF downloadLoading ...
Tc-99m HMPAO SPECT of the Brain in the Neonate
Authors: DANIEL S. FOCKELE, ROBERT J. BAUMANN, WEI-JEN SHIH, U. YUN RYO
Journal: Clinical Nuclear Medicine (1990)

A brain scan with Tc-99m hexamethylpropyleneamineox-ime (HMPAO) performed on a neonate demonstrated normal localization only in the sensorimotor cortex, basal ganglia, and cerebellum. This pattern of localization is remarkably similar to previously published PET images of the neonate. Because Tc-99m HMPAO is readily available and has biochemical and physical characteristics that are suitable for perfusion imaging of the brain, it likely will become a major imaging agent in nuclear medicine. Normal scan findings in the neonatal age group with Tc-99m HMPAO have not been previously reported because of limited clinical use to date.
Mechanical Cardiac Support 2000: Current Applications and Future Trial Design
Authors: Lynne Warner Stevenson, Robert L. Kormos, Mark L. Barr, Maria Rosa Costanzo, Patrice Desvigne-Nickens, Arthur Michael Feldman, O. Howard (BUD) Frazier, Lawrence Friedman, J. Donald Hill, Marvin A. Konstam, Patrick McGuane McCarthy, Robert E. Michler, Mehmet C. Oz, Bruce R. Rosengard, Wolf Sapirstein, Rhona Shanker, Craig R. Smith, Randall C. Starling, David O. Taylor, Alison Wichman
Journal: Circulation (2001)
Assessment of the effect of respiration on the esophageal variceal blood flow using transesophageal real-time two-dimensional doppler echography
Authors: Minoru Sukigara, Masahiko Ohata, Toshiro Komazaki, Ryozo Omoto
Journal: Hepatology (1988)

The effect of spontaneous respiration on esophageal variceal flow was evaluated using 5 MHz color flow Doppler echography. Twenty-one patients with esophageal varices, of whom 19 had liver cirrhosis (95%), were examined with a convex array transesophageal transducer. The direction and velocity of the variceal flow during inhalation and exhalation could be inferred from the color, its brightness or the Doppler time-velocity spectrum. The mean intravariceal flow velocity was significantly higher during inhalation (20.6 cm per sec) than in exhalation (11.5 cm per sec; p less than 0.01). The direction of intravariceal flow at any given point did not change throughout the respiratory cycle. However, a combination of real-time color flow imaging and the doppler time-velocity spectrum revealed that, when the sampling point was near the peak of the curve of the varix, the spectrum falsely indicated reversal of direction between inhalation and exhalation. This semiinvasive method, which yields anatomical and physiological information simultaneously, appears to be very useful for the study of variceal flow.
Preventive Care for Elderly People
Authors: B Livesley
Journal: BMJ (1994)

David C Kennie Cambridge University Press, £17.95, pp 321 ISBN 0-521-43629-X

From his interest in preventive care gained at Duke University, North Carolina, and now as a member of a Forth Valley Health Board subgroup in Scotland, David Kennie has produced a text that “examines the concepts of preventive care and health promotion specifically in the context of an elderly population.” The potential benefits of such strategies for 64 common health problems affecting elderly people are discussed in four chapters. Cancers and non-cancerous …
Modulation of Pituitary Responsiveness to Throtropin-Releasing Hormone by Triiodothyronine
Authors: Louis Shenkman, Terunori Mitsuma, Charles S. Hollander
Journal: Journal of Clinical Investigation (1973)

The relative roles of triiodothyronine (T3) and thyroxine (T4) in modulating pituitary responsiveness to thyrotropin-releasing hormone (TRH) have been assessed. (a) 10 hyperthyroid patients with elevated serum T2 and T4 levels showed no pituitary response to TRH. After 2 wk of propylthiouracil therapy T4 levels had fallen to normal in only five patients while T2 levels were normal in all. Pituitary responsiveness to TRH returned in all patients with normal or high T4 concentrations. (b) Patients with isolated elevations of serum T3 (T3 toxicosis) failed to respond to TRH. TRH responsiveness was restored when T3 levels fell to normal after propylthiouracil therapy. (c) When pituitary responsiveness to TRH was tested 60 min after a single oral dose of 50 μg of T3, which increased serum T3 levels to slightly above the normal range, no rise in thyrotropin (TSH) was seen in six subjects. These findings indicate that T3 elevations alone can rapidly inhibit pituitary responsiveness to TRH.
Whiplash and Other Useful Illnesses
Authors: M. Fitzpatrick
Journal: BMJ (2003)

Andrew Malleson McGill-Queen's University Press, £26.95, pp 544 ISBN 0 7735 2333 2 www.mqup.ca Rating: ![Graphic][1]</img>![Graphic][2]</img>![Graphic][3]</img>![Graphic][4]</img> Andrew Malleson observes that “victimhood can bring much gratification.” As he indicates, the high social status currently accorded to the victim is an important factor in the rise of “dissimulating disorders,” in which patients present chronic physical symptoms for which no organic cause can be found. American psychiatry recognises three categories of these disorders: malingering, factitious disorders, and somatoform disorders. Malingering is where symptoms are intentionally produced with … [1]: /embed/inline-graphic-1.gif [2]: /embed/inline-graphic-2.gif [3]: /embed/inline-graphic-3.gif [4]: /embed/inline-graphic-4.gif
Haemodynamic and regional blood flow changes after acute pulmonary microembolism in conscious rabbits
Authors: R. B WANLESS, I. S ANAND, P. A POOLE-WILSON, P. HARRIS
Journal: Cardiovascular Research (1988)

The central and peripheral haemodynamic effects of pulmonary embolisation with microspheres were measured in conscious rabbits in which the autonomic and central nervous systems were functioning normally. Sufficient microspheres were given to reduce cardiac output (measured by thermodilution) by one half. This fall in cardiac output was accompanied by a severe fall in arterial pressure and an increase in heart rate and right atrial pressure. Under these conditions cardiac output responded less than normally to an increased right atrial pressure imposed by an infusion of saline. Changes in regional blood flow and resistance were measured with radioactive microspheres injected into the left ventricle. Myocardial blood flow was unaffected by pulmonary embolisation. Cerebral flow was slightly increased. Renal, intestinal, dermal, and skeletal muscle blood flows were all reduced. Myocardial and cerebral tissue vascular resistances decreased; splenic and dermal vascular resistances increased; and renal and skeletal muscle vascular resistances were unchanged.
Common variants at MS4A4/MS4A6E, CD2AP, CD33 and EPHA1 are associated with late-onset Alzheimer's disease
Authors: Adam C Naj, Gyungah Jun, Gary W Beecham, Li-San Wang, Badri Narayan Vardarajan, Jacqueline Buros, Paul J Gallins, Joseph D Buxbaum, Gail P Jarvik, Paul K Crane, Eric B Larson, Thomas D Bird, Bradley F Boeve, Neill R Graff-Radford, Philip L De Jager, Denis Evans, Julie A Schneider, Minerva M Carrasquillo, Nilufer Ertekin-Taner, Steven G Younkin, Carlos Cruchaga, John S K Kauwe, Petra Nowotny, Patricia Kramer, John Hardy, Matthew J Huentelman, Amanda J Myers, Michael M Barmada, F Yesim Demirci, Clinton T Baldwin, Robert C Green, Ekaterina Rogaeva, Peter St George-Hyslop, Steven E Arnold, Robert Barber, Thomas Beach, Eileen H Bigio, James D Bowen, Adam Boxer, James R Burke, Nigel J Cairns, Chris S Carlson, Regina M Carney, Steven L Carroll, Helena C Chui, David G Clark, Jason Corneveaux, Carl W Cotman, Jeffrey L Cummings, Charles DeCarli, Steven T DeKosky, Ramon Diaz-Arrastia, Malcolm Dick, Dennis W Dickson, William G Ellis, Kelley M Faber, Kenneth B Fallon, Martin R Farlow, Steven Ferris, Matthew P Frosch, Douglas R Galasko, Mary Ganguli, Marla Gearing, Daniel H Geschwind, Bernardino Ghetti, John R Gilbert, Sid Gilman, Bruno Giordani, Jonathan D Glass, John H Growdon, Ronald L Hamilton, Lindy E Harrell, Elizabeth Head, Lawrence S Honig, Christine M Hulette, Bradley T Hyman, Gregory A Jicha, Lee-Way Jin, Nancy Johnson, Jason Karlawish, Anna Karydas, Jeffrey A Kaye, Ronald Kim, Edward H Koo, Neil W Kowall, James J Lah, Allan I Levey, Andrew P Lieberman, Oscar L Lopez, Wendy J Mack, Daniel C Marson, Frank Martiniuk, Deborah C Mash, Eliezer Masliah, Wayne C McCormick, Susan M McCurry, Andrew N McDavid, Ann C McKee, Marsel Mesulam, Bruce L Miller, Carol A Miller, Joshua W Miller, Joseph E Parisi, Daniel P Perl, Elaine Peskind, Ronald C Petersen, Wayne W Poon, Joseph F Quinn, Ruchita A Rajbhandary, Murray Raskind, Barry Reisberg, John M Ringman, Erik D Roberson, Roger N Rosenberg, Mary Sano, Lon S Schneider, William Seeley, Michael L Shelanski, Michael A Slifer, Charles D Smith, Joshua A Sonnen, Salvatore Spina, Robert A Stern, Rudolph E Tanzi, John Q Trojanowski, Juan C Troncoso, Vivianna M Van Deerlin, Harry V Vinters, Jean Paul Vonsattel, Sandra Weintraub, Kathleen A Welsh-Bohmer, Jennifer Williamson, Randall L Woltjer, Laura B Cantwell, Beth A Dombroski, Duane Beekly, Kathryn L Lunetta, Eden R Martin, M Ilyas Kamboh, Andrew J Saykin, Eric M Reiman, David A Bennett, John C Morris, Thomas J Montine, Alison M Goate, Deborah Blacker, Debby W Tsuang, Hakon Hakonarson, Walter A Kukull, Tatiana M Foroud, Jonathan L Haines, Richard Mayeux, Margaret A Pericak-Vance, Lindsay A Farrer, Gerard D Schellenberg
Journal: Nature Genetics (2011)
SURGICAL TREATMENT OF AORTIC STENOSIS
Authors: C. P. Bailey
Journal: JAMA (1952)

Aortic stenosis is a relatively uncommon valvular condition, according to Bell,<sup>1</sup>and is usually produced by the ravages of rheumatic fever. Occasionally, it may be of congenital origin, the valve being fused into a tiny megaphone-like shape or cone similar to the condition found in congenital pulmonary valvular stenosis. On other occasions it may be seen as the end result of arteriosclerotic changes in the root of the aorta. It should not be confused with congenital subaortic stenosis, which is a less serious clinical condition analogous in some respects to congenital infundibular stenosis of the right ventricular outflow tract. Reich<sup>2</sup>feels that the arteriosclerotic form of aortic stenosis is fairly common. Here, the fibrosis and calcification begin in the aortic wall and involve the entire valve structure, producing a replacement with rigid tissue. Often, there is no fusion of the valve commissures in such patients, each rigid leaflet
Telecare for Patients With Type 1 Diabetes and Inadequate Glycemic Control
Authors: Victor M. Montori, Gordon H. Guyatt, Steven A. Smith, Yogish C. Kudva
Journal: Diabetes Care (2005)

We thank Biermann et al. (1) for their kind remarks about the clarity and importance of our research and for proposing a novel taxonomy of telecare interventions by purpose: as a supplement to usual care (A in their taxonomy) or as a replacement of face-to-face visits (sometimes called nonvisit encounters; B or C in their taxonomy).

Two of the trials included in our meta-analysis used, to some extent, telecare as replacement. In their 6-month trial, Chase et al. …
RIFT VALLEY FEVER
Authors: Thomas Francis, T. P. Magill
Journal: The Journal of Experimental Medicine (1935)

Three cases of Rift Valley fever in human individuals are reported. The virus was recovered from the respiratory tract of the patients and was transmitted to ferrets by the intranasal route. The experimental disease so produced in ferrets is characterized by fever, marked pulmonary lesions, and hemorrhagic phenomena. The results indicate that the virus of Rift Valley fever belongs to the group of filterable viruses which may gain entrance to the human body through the respiratory tract. The differential diagnosis of Rift Valley fever and influenza is discussed. While, clinically, this is a difficult problem, the diagnosis may be readily established through animal experimentation. Certain observations concerning the influence of the route of administration on the protective action of immune serum in serum-virus mixtures are presented.
Liver Disease and Aspergillosis-Reply
Authors: James F. Burke
Journal: JAMA (1983)

<h3>In Reply.—</h3> We thank Dr Varkey for his interest in our article. We agree that liver disease can impair host defense mechanisms and increase susceptibility to many types of infections, including aspergillosis. As Dr Varkey mentioned, we did discuss this in our article, and we agree with his caveat. However, we still believe that this patient did not have any preexisting severe liver disease, since he had no preexisting clinical or pathological stigmata of chronic liver disease and no pathological evidence of acute alcoholic hepatitis. The changes seen in the liver unrelated to the<i>Aspergillus</i>abscesses were probably caused by his shocklike state, which evolved over his hectic clinical course. Administration of the steroids was started, of course, after the illness was already manifest, and could not be considered causal in this case.
Future Options for General Practice
Authors: C. Watkins
Journal: BMJ (1996)

Ed Geoff Meads Radcliffe, pounds sterling16.50, pp 232 ISBN 1 85775 079 9

There is a distinction between invention and innovation, which June Huntington illustrates in her chapter by quoting from Peter Senge's The Fifth Discipline:

that cold clear morning…when the fragile aircraft of Wilbur and Orville Wright proved that powered flight was possible. Thus was the airplane invented; but it would take more than thirty years before commercial aviation could serve the general public. Engineers say that a new idea has been ‘invented’ when it is proven to work in the laboratory. The idea becomes an ‘innovation’ only when it can be replicated …
Prenatal ultrasound examinations and risk of childhood leukaemia: case-control study
Authors: E. Naumburg
Journal: BMJ (2000)

ConclusionPatients are not disadvantaged by the introduction of outpatient hysteroscopy.Several advantages may prove attractive to patients and healthcare providers: return to mobility, full fitness, and work occur more quickly after outpatient hysteroscopy than after day case hysteroscopy.Increased attention should be paid during counselling of patients at higher risk of dissatisfaction with hysteroscopy, such as postmenopausal patients.The development of outpatient hysteroscopy is a potentially significant advance in gynaecological investigation.It lends itself to a greater accessibility for general practitioners and patients, especially if a direct referral service from a general practitioner is contemplated.Contributors: MA and SD conceived and designed the study.CK performed all the procedures and collected and analysed the data.CK and SD wrote the paper.
Adult Still's Disease Complicated by Cardiac Tamponade
Authors: Thomas W. Jamieson
Journal: JAMA (1983)

SYSTEMIC-onset juvenile rheumatoid arthritis in the adult (adult Still's disease) is a clinical diagnosis. It is not a diagnosis made with the aid of serological studies, but rather can only be made by a suspecting clinician as he constructs a patient's composite clinical profile. A sufficient awareness of the disease's features is needed to avoid unnecessary diagnostic procedures and delay in commenceing therapy.<sup>1</sup>This case report examines the panorama of clinical features that can be seen in adult Still's disease and reports a rare complication: pericardial effusion with cardiac tamponade. <h3>Report of a Case</h3> A 21-year-old man was admitted to a hospital in Panama in July 1981 with a two-week history of sore throat, fever, chills, myalgias, arthralgias (hips, shoulders, metacarpal phalangeal joints, proximal interphalangeal joints, and right knee), and weight loss. There was no history of drug intake (medical or nonmedical) before the onset of symptoms. The patient