STUDIES OF CHOLESTEROL SYNTHESIS IN MAN USING CARBON^14 LABELED ACETATE
Authors: G V LEROY
Journal: Annals of Internal Medicine (1956)

Article1 March 1956STUDIES OF CHOLESTEROL SYNTHESIS IN MAN USING CARBON14 LABELED ACETATEGEORGE V. LEROY, M.D.GEORGE V. LEROY, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-44-3-524 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptCholesterol is an important constituent of the body. The total amount in a 70 kg. man is 0.3% of the wet weight, or 210 gm. The content of individual tissues ranges from 0.12% in red cells to 4.5% in the adrenal gland.1Since practically no cholesterol is oxidized to carbon dioxide to yield energy, it is of interest to investigate the function of this relatively abundant solid alcohol. It is known that certain bile acids and their salts, which are important for the digestion of fat, are derived from cholesterol. The plasma cholesterol is believed to play a key rôle...Bibliography1. Fieser LF: Some aspects of the chemistry and biochemistry of cholesterol, Science 119: 710-716 (May 21) 1954. CrossrefMedlineGoogle Scholar2. BlochRittenberg KD: On the utilization of acetic acid for cholesterol formation, J. Biol. Chem. 145: 625, 1942. CrossrefGoogle Scholar3. EcklesTaylorCampbellGould NECBDJRG: The origin of plasma cholesterol and the rates of equilibration of liver, plasma and erythrocyte cholesterol, J. Lab. and Clin. Med. 46: 359, 1955. MedlineGoogle Scholar4. LeRoy GV: Studies of extrahepatic synthesis of cholesterol in man using a double tracer technic, to be published. Google Scholar5. BiggsKritchevskyColmanGofmanJonesLindgrenHydeLyon MWDDJWHBTTGTP: Observations on the fate of ingested cholesterol in man, Circulation 6: 359, 1952. CrossrefMedlineGoogle Scholar6. HellmanRosenfeldEidinoffFukushimaGallagherWangAdlersberg LRSMLDKTFCID: Isotopic studies of plasma cholesterol of endogenous and exogenous origin, J. Clin. Investigation 34: 48-60, 1955. CrossrefMedlineGoogle Scholar7. LondonRittenberg IMD: Deuterium studies in normal man. I. The rate of synthesis of serum cholesterol, J. Biol. Chem. 184: 697, 1950. CrossrefMedlineGoogle Scholar8. KurlandLucasFreedberg GSJLAS: The metabolism of intravenously infused C14 labeled cholesterol in man, J. Clin. Investigation 33: 950, 1954. Google Scholar9. HellmannRosenfeldGallagher LRSTF: Cholesterol synthesis from C14-acetate in man, J. Clin. Investigation 33: 142-149, 1954. CrossrefMedlineGoogle Scholar10. GouldLeRoyOkitaKabaraKeeganBergenstal RGGVGTJJPDM: The use of C14 labeled acetate to study cholesterol metabolism in man, J. Lab. and Clin. Med. 46: 372, 1955. MedlineGoogle Scholar11. Bergenstal DM, in preparation. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Chicago, Illinois*Presented as a Morning Lecture at the Thirty-sixth Annual Session of The American College of Physicians, Philadelphia, Pennsylvania, April 27, 1955.From the Department of Medicine, University of Chicago, Chicago, Illinois. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byCholesterol metabolism in hypothyroidism and hyperthyroidism in man.Dextrothyroxine for Lowering Serum CholesterolPlacental transfer of cholesterol-4-14C into rabbit and guinea pig fetusIncorporation of C14-acetate in cholesterol and fatty acids of the liver of adrenalectomized rats during irradiationThyroid Analogs as Cholesteropenic AgentsAbnormalities of cholesterol metabolism in hypothyroidism and the effects of treatment with thyroid hormones and thyroxin analoguesKrankheiten der GefäßeLiver Function Tests-Their Clinical SignificanceCholesterol and Its Relation to AtherosclerosisCurrent concepts of lipide metabolismThe Use of I131 Triolein in the Study of Absorptive Disorders in Man 1 March 1956Volume 44, Issue 3Page: 524-533KeywordsAtherosclerosisBileBlood plasmaCarbon dioxideCellsCholesterolDigestionFatsSaltsSteroid hormones ePublished: 1 December 2008 Issue Published: 1 March 1956 PDF downloadLoading ...