Minocycline Treatment of Rheumatoid Arthritis
Authors: Harold E. Paulus
Journal: Annals of Internal Medicine (1995)

Editorials15 January 1995Minocycline Treatment of Rheumatoid ArthritisHarold E. Paulus, MDHarold E. Paulus, MDUniversity of California, Los Angeles, School of Medicine; Los Angeles, CA 90024-1670Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-122-2-199501150-00012 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail Two recent reports have created renewed interest in antibiotic treatment of rheumatoid arthritis: In this issue, Tilley and colleagues [1] report the findings of the large double-blind, placebo-controlled Minocycline in Rheumatoid Arthritis (MIRA) clinical trial; in 1994, Kloppenburg and colleagues [2] reported the results of a similar study from the Netherlands. In 1968, Sanchez [3] first reported the use of tetracycline to treat 14 patients with rheumatoid arthritis, with favorable results. McPherson-Brown and colleagues [4] also found good results in a retrospective cohort study of 98 patients with rheumatoid arthritis who were treated with antibiotics from 1978 to 1982. However, ...References1. Tilley BC, Alarcon GS, Heyse SP, Trentham DE, Neuner R, Kaplan DA, et al. Minocycline in rheumatoid arthritis. A 48-week double-blind, placebo-controlled trial. Ann Intern Med. 1995; 122:81-9. Google Scholar2. Kloppenburg M, Breedveld FC, Terwiel JP, Mallee C, Dijkmans BA. Minocycline in active rheumatoid arthritis. A double-blind, placebo-controlled trial. Arthritis Rheum. 1994; 37:629-36. Google Scholar3. Sanchez I. Tetracycline treatment in rheumatoid arthritis and other rheumatic diseases. (As tetraciclinas no tratamento da artrite reumatoide e doencas reumaticas inflamatorias.) Brazilian Journal of Medicine. 1968; 82:21-31. Google Scholar4. McPherson-Brown T, Hochberg MD, Hicks JT. Antibiotic therapy of rheumatoid arthritis. A retrospective cohort study of 98 patients with 451 patient-years of follow-up (Abstract). Congress of Rheumatology. 1985:S85. Google Scholar5. Skinner M, Cathcart ES, Mills JA, Pinals RS. Tetracycline in the treatment of rheumatoid arthritis. A double blind controlled study. Arthritis Rheum. 1971; 14:727-32. Google Scholar6. Langevitz P, Bank I, Zemer D, Book M, Pras M. Treatment of resistant rheumatoid arthritis with minocycline: an open study. J Rheumatol. 1992; 19:1502-4. Google Scholar7. Breedveld FC, Dijkmans BA, Mattie H. Minocycline treatment for rheumatoid arthritis: an open dose finding study. J Rheumatol. 1990; 17:43-6. Google Scholar8. Ennis RS, Johnson JS, Decker JL. Persistent mycoplasma hyorhinis (MH) antigen in chronic mycoplasmal arthritis of swine. Arthritis Rheum. 1972; 15:108. Google Scholar9. Smith DE, James PG, Schachter J, et al. Experimental bedsonial arthritis. Arthritis Rheum. 1973; 16:21-9. Google Scholar10. Taylor-Robinson D, Gilroy CB, Thomas BJ, Keat AC. Detection of Chlamydia trachomatis DNA in joints of reactive arthritis patients by polymerase chain reaction. Lancet. 1992; 340:81-2. Google Scholar11. Nip LH, Uitto VJ, Golub LM. Inhibition of epithelial cell matrix metalloproteinases by tetracyclines. J Periodontal Res. 1993; 28:379-85. Google Scholar12. Sorsa T, Konttinen YT, Lindy O, Ritchlin C, Saari H, Suomalainen K, et al. Collagenase in synovitis of rheumatoid arthritis. Semin Arthritis Rheum. 1992; 22:44-53. Google Scholar13. Greenwald RA, Golub LM, Lavietes B, Ramamurthy NS, Gruber B, Laskin RS, et al. Tetracyclines inhibit human synovial collagenase in vivo and in vitro. J Rheumatol. 1987; 14:28-32. Google Scholar14. Pruzanski W, Greenwald RA, Street IP, Laliberte F, Stefanski E, Vadas P. Inhibition of enzymatic activity of phospholipases A2 by minocycline and doxycycline. Biochem Pharmacol. 1992; 44:1165-70. Google Scholar15. Vadas P, Pruzanski W, Kim J, Fornasier V. The proinflammatory effect of intra-articular injection of soluble human and venom phospholipase A2. Am J Pathol. 1989; 134:807-11. Google Scholar16. Golub LM, Suomalainen K, Sorsa T. Host modulation with tetracyclines and their chemically modified analogues. Curr Opin Dent. 1992; 2:80-90. Google Scholar17. Kloppenburg M, Miltengburg AM, Verdonk MJ, et al. Minocycline inhibits T cell proliferation and interferon γ (IFN-γ) production after stimulation with anti-CD3 monoclonal antibodies. Br J Rheumatol. 1992; 31:S41. Google Scholar Author, Article, and Disclosure InformationAuthors: Harold E. Paulus, MDAffiliations: University of California, Los Angeles, School of Medicine; Los Angeles, CA 90024-1670Corresponding Author: Harold E. Paulus, MD, University of California, Los Angeles, School of Medicine, 1000 Veteran Avenue, 32-41, Los Angeles, CA 90024-1670. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoMinocycline in Rheumatoid Arthritis: A 48-Week, Double-Blind, Placebo-Controlled Trial Barbara C. Tilley , Graciela S. Alarcon , Stephen P. Heyse , David E. Trentham , Rosemarie Neuner , David A. Kaplan† , Daniel O. Clegg , James C. C. Leisen , Lenore Buckley , Sheldon M. Cooper , Howard Duncan , Stanley R. Pillemer , Marilyn Tuttleman , and Sarah E. 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