Serum Insulin, Carbohydrate, and Lipid Abnormalities in Patients with Premature Coronary Heart Disease
Authors: MANUEL TZAGOURNIS
Journal: Annals of Internal Medicine (1967)

Article1 July 1967Serum Insulin, Carbohydrate, and Lipid Abnormalities in Patients with Premature Coronary Heart DiseaseMANUEL TZAGOURNIS, M.D., JOHN F. SEIDENSTICKER, M.D., GEORGE J. HAMWI, M.D., F.A.C.P.MANUEL TZAGOURNIS, M.D.Search for more papers by this author, JOHN F. SEIDENSTICKER, M.D.Search for more papers by this author, GEORGE J. HAMWI, M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-67-1-42 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptAbnormal glucose metabolism and elevated serum lipids have been intimately related to atherosclerosis. Coronary atherosclerosis is more prevalent in diabetics than in nondiabetics (1). Conversely, hyperglycemia is commonly found in patients suffering from peripheral or coronary atherosclerosis (2). Elevated levels of serum cholesterol and triglycerides have been shown to be associated with coronary heart disease (CHD) (3, 4).The serum insulin response to glucose in maturity-onset diabetes is characterized by a delayed secretion, and the levels are often elevated. Abnormal insulin responses have also been noted in association with high plasma triglycerides independent of clinical diabetes (5). Obesity, another condition...References1. BELL ET: A post mortem study of vascular disease in diabetes. Arch. Path. (Chicago) 53: 444, 1952. MedlineGoogle Scholar2. OSTRANDERFRANCISHAYNERKJELSBERGEPSTEIN LDTNSMOFH: The relationship of cardiovascular disease to hyperglycemia. Ann. Intern. Med. 62: 1188, 1965. LinkGoogle Scholar3. KANNELDAWBERFRIEDMANGLENNONMCNAMARA WBTRGDWEPM: Risk factors in coronary heart disease. An evaluation of several serum lipids as predictors of coronary heart disease; the Framingham study. Ann. Intern. Med. 61: 888, 1964. LinkGoogle Scholar4. ALBRINKMEIGSMAN MJJWEB: Serum lipids, hypertension and coronary artery disease. Amer. J. Med. 31: 4, 1961. CrossrefMedlineGoogle Scholar5. DAVIDSONALBRINK PCMJ: Abnormal plasma insulin response with high plasma triglycerides independent of clinical diabetes or obesity. J. Clin. Invest. 45: 1000, 1966. Google Scholar6. WELBORNBRECKENRIDGERUBINSTEINDOLLERYFRASER TAAAHCTTR: Serum-insulin in essential hypertension and in peripheral vascular disease. Lancet 1: 1336, 1966. CrossrefMedlineGoogle Scholar7. NIKKILÄMIETTINENVESSENEPALLCONIN EATAMRR: Plasma-insulin in coronary heart-disease: response to oral and intravenous glucose and to tolbutamide. Lancet 2: 508, 1965. CrossrefMedlineGoogle Scholar8. PETERSHALES NCN: Plasma-insulin concentrations after myocardial infarction. Lancet 1: 1144, 1965. CrossrefMedlineGoogle Scholar9. ABELLLEVYBRODIEKENDALL LLBBBBFE: A simplified method for the estimation of total cholesterol in serum and demonstration of its specificity. J. Biol. 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WILKERSON HL: Diagnosis: oral glucose tolerance tests, in Diabetes Mellitus: Diagnosis and Treatment, edited by DANOWSKI, T. S. American Diabetes Association, Inc., New York, 1964, p. 31. Google Scholar16. PAGEGREENROBERTSON IHJGAL: The physician's incomplete guide to atherosclerosis. Ann. Intern. Med. 64: 189, 1966. LinkGoogle Scholar17. PAGE IH: Arteriosclerosis and lipid metabolism. Biol. Sympos. 11: 43, 1945. Google Scholar18. BUCK RC: The fine structure of the aortic endothelial lesions in experimental cholesterol atherosclerosis of rabbits. Amer. J. Path. 34: 897, 1958. MedlineGoogle Scholar19. HOLMANMCGILLSTRONGGEERGUIDRY RCHCJPJCMA: The arterial wall as an organ, in Hormones and Atherosclerosis, edited by PINCUS, G. Academic Press, Inc., Publishers, New York, 1959, p. 23. CrossrefGoogle Scholar20. MAHLER R: Diabetes and arterial lipids (abstract). Quart. J. Med. 34: 484, 1965. Google Scholar21. CHRISTAKISRINZLERARCHERKRAUS GSHMA: Effect of the anti-coronary club program on coronary heart disease risk-factor status. JAMA 198: 129, 1966. CrossrefGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Columbus, OhioFrom the Division of Endocrinology and Metabolism, Department of Medicine, Ohio State University Hospitals, Columbus, Ohio.This study was supported in part by training grant NIAMD T1 AM 5118, U. S. Public Health Service, Washington, D. C., and by the Ohio State University Endocrine Research Fund—Rotary 525-275, Columbus, Ohio.Portions of this study were presented at the Regional Meeting of the American College of Physicians, January 20, 1967, Morgantown, W. Va.Requests for reprints should be addressed to Manuel Tzagournis, M.D., Ohio State University Hospitals, 410 W. Tenth Ave., Columbus, Ohio 43210. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByInsulin and AtherosclerosisRelationship between plasma cholesterol and coronary artery disease in AsiansIschaemic heart disease in people of Indian subcontinent originMyocardial infarction in young adults under 30 years: Risk factors and clinical courseMyocardial infarction in young adults: Risk factors and natural historyMyocardial Infarction at Young Age: Risk Factors and Natural HistoryKinetics of insulin secretion following glucose infusion in patients with atherosclerotic peripheral vascular diseaseUsefulness of serum lipid determination in diabetic practiceValid Parental ConsentATHEROGENIC HORMONESConclusionsHormonal Regulation of Cholesterol SynthesisEffects of palm-kernel oil and sunflower-seed oil on serum lipids and atherogenesis in alloxan-diabetic rabbitsDiabetes and the heartTYPE-IV HYPERLIPIDÆMIA AND WEIGHT-GAIN AFTER MATURITYCoronary artery disease in young patients: Arteriographic and clinical review of 40 cases aged 35 and underLIST OF REFERENCESNutritional therapy in acute myocardial infarctionCoronary Heart Disease in Young Men: A Study of Seventy Patients with a Critical Review of Etiological Factors*REFERENCESChapter 19. AtherosclerosisGlucose tolerance, plasma lipids and atherosclerosisIschemic Heart DiseaseThe role of endogenous insulin in different hyperlipidemic statesHyperlipoproteinemia and coronary heart diseaseThe incidence of plasma insulin, blood sugar and serum lipid abnormalities in patients with atherosclerotic diseaseABNORMAL INSULIN RESPONSE IN PATIENTS WITH SMALL-VESSEL DISEASEINSULIN RESPONSE TO GLUCOSE IN PATIENTS WITH PERIPHERAL VASCULAR DISEASE, ARTERITIS, AND RAYNAUD'S PHENOMENONHormonal and metabolic disturbances during acute and subacute myocardial infarction in manThe Pattern of Plasma Insulin Response to Glucose in Patients with a Previous Myocardial Infarction-The Respective Effects of Age and DiseaseDiabetes e hiperlipoproteinemia en la enfermedad aterosclerosa del coraz�nHyperlipidemia in Atherosclerosis: Dietary and Drug TreatmentReferencesElectrocardiography and Carbohydrate MetabolismINSULIN AND ATHEROMAInterrelationships of Hyperinsulinism and Hypertriglyceridemia in Young Patients with Coronary Heart DiseaseHyperinsulinism with hypoglycemia following acute myocardial infarctionINSULIN-STIMULATED LIPOGENESIS IN ARTERIAL TISSUE IN RELATION TO DIABETES AND ATHEROMACurrent Metabolic-Genetic Interrelationship in Human Atherosclerosis With Therapeutic ConsiderationsPETER T. KUO, M.D., F.A.C.P.PREDNISONE-GLUCOSE TOLERANCE AND SERUM LIPIDS IN SURVIVORS OF MYOCARDIAL INFARCTION 1 July 1967Volume 67, Issue 1Page: 42-47KeywordsCoronary heart diseaseEndocrinologyHyperglycemiaInsulinInsulin secretionLipidsMedical servicesObesityStable coronary artery diseaseType 2 diabetes Issue Published: 1 July 1967 PDF DownloadLoading ...