THE ANALGESIC EFFECT OF HEPATITIS AND JAUNDICE IN CHRONIC ARTHRITIS, FIBROSITIS AND SCIATIC PAIN
Authors: Philip S. Hench
Journal: Annals of Internal Medicine (1934)

Article1 April 1934THE ANALGESIC EFFECT OF HEPATITIS AND JAUNDICE IN CHRONIC ARTHRITIS, FIBROSITIS AND SCIATIC PAINPHILIP S. HENCH, M.D., F.A.C.P.PHILIP S. HENCH, M.D., F.A.C.P.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-7-10-1278 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptIn the last four years I have observed a number of patients whose pain, caused by arthritis, fibrositis or sciatica, was markedly, usually completely, relieved coincident with the appearance of intrahepatic jaundice. In two cases the jaundice apparently was not induced by any drug; in the other cases it resulted from cinchophen. However, the analgesia was not caused by the cinchophen, as will appear.Cases of "cinchophen hepatitis" afford opportunities for studying analgesia associated with icterus, for the cinchophen is generally taken for a chronic type of pain, usually that of long standing "rheumatism." Two particularly striking examples of the...Bibliography1. HENCH PS: Derivatives of cinchophen and their toxicity, Proc. Staff Meet., Mayo Clinic, 1932, vii, 427-428; New Eng. Jr. Med., 1932, ccvii, 949-950. Google Scholar2. WEIRCOMFORT JFMW: Toxic cirrhosis caused by cinchophen, Arch. Int. Med., 1933, lii, 685-724. CrossrefGoogle Scholar3. BEAVERROBERTSON DCHE: Specific character of toxic cirrhosis as observed in cinchophen poisoning, a review of five fatal cases, Am. Jr. Path., 1931, vii, 237-257. Google Scholar4. SNELLJORDAN AMFM: Intrahepatic jaundice, Northwest Med., 1930, xxix, 295-303. Google Scholar5. WEIRJORDAN JFFM: Clinical consideration of some types of intrahepatic jaundice, Med. Clin. N. 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Am., 1928, xi, 1025-1041. Google Scholar13. RABINOWITZ MA: Atrophy of liver due to cinchophen preparations, Jr. Am. Med. Assoc., 1930, xcv, 1228-1232. CrossrefGoogle Scholar14. ROSS JB: Liver damage following cinchophen preparations, with report of five cases, Canadian Med. Assoc. Jr., 1931, xxiv, 632-634. Google Scholar15. WINFIELD GA: Toxic hepatitis due to cinchophen: report of three cases, Canadian Med. Assoc. Jr., 1932, xxvi, 170-174. Google Scholar16. REAH TJ: Cinchophen poisoning, Lancet, 1932, ii, 504-509. CrossrefGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Rochester, Minnesota*Read before the Second Conference on Rheumatic Diseases, of the American Committee for the Control of Rheumatism, Milwaukee, Wisconsin, June 12, 1933.From the Division of Medicine, The Mayo Clinic. 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