SUBACUTE BACTERIAL ENDOCARDITIS OCCURRING IN A PATIENT RECEIVING ORAL PENICILLIN AS PROPHYLAXIS AGAINST RHEUMATIC FEVER
Authors: D S DOCK, L B GUZE
Journal: Annals of Internal Medicine (1957)

Case Reports1 September 1957SUBACUTE BACTERIAL ENDOCARDITIS OCCURRING IN A PATIENT RECEIVING ORAL PENICILLIN AS PROPHYLAXIS AGAINST RHEUMATIC FEVERDONALD S. DOCK, M.D., LUCIEN B. GUZE, M.D.DONALD S. DOCK, M.D.Search for more papers by this author, LUCIEN B. GUZE, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-47-3-577 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptINTRODUCTIONSubacute bacterial endocarditis has occurred in patients with valvular heart disease following operative procedures within the oral cavity despite the use of penicillin to prevent the transient bacteremia which may occur in such situations.1-4In addition, bacterial endocarditis has been noted in patients receiving prophylactic penicillin against recurrent beta-hemolytic streptococcal infection. Hunter has observed one such instance in a child receiving oral penicillin.5Two additional cases appeared among a group of 145 subjects with a history of rheumatic fever who were receiving monthly injections of benzathine penicillin; the causative organisms were penicillin-sensitiveStreptococcus viridans.6One of these patients had...Bibliography1. GoernerGeigerBlake JRAJFG: Treatment of subacute bacterial endocarditis with penicillin: report of cases treated without anticoagulant agents, Ann. Int. Med. 23: 491, 1945. LinkGoogle Scholar2. Hunter TH: Treatment of subacute bacterial endocarditis, Mod. Concepts Cardiovas. Dis. 15: No. 8, 1946. MedlineGoogle Scholar3. ThillMeyer CJOO: Experiences with penicillin and Dicumarol in the treatment of subacute bacterial endocarditis, Am. J. M. Sc. 213: 300, 1947. CrossrefMedlineGoogle Scholar4. CatesChristieGarrod JERVLP: Penicillin-resistant subacute bacterial endocarditis treated by a combination of penicillin and streptomycin, Brit. M. 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MedlineGoogle Scholar24. Eagle H: Experimental approach to the problem of treatment failure with penicillin. I. Group A streptococcal infection in mice, Am. J. Med. 13: 389, 1952. CrossrefMedlineGoogle Scholar25. DarnellPeschGlaser JEBBRJ: Effect of penicillin on Group A streptococci in vivo in the absence of leucocytes, J. Clin. Investigation 34: 1237, 1955. CrossrefMedlineGoogle Scholar26. WoodSmith WBMR: An experimental analysis of the curative action of penicillin in acute bacterial infections. I. The relationship of bacterial growth rates to the antimicrobial effect of penicillin, J. Exper. Med. 103: 487, 1956. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: DONALD S. DOCK, M.D.; LUCIEN B. GUZE, M.D.*Received for publication March 16, 1957.From the Department of Internal Medicine, Yale University School of Medicine, New Haven, Conn.†Research Fellow of the American Heart Association.Requests for reprints should be addressed to Donald S. Dock, M.D., Department of Internal Medicine, Yale University School of Medicine, New Haven 11, Connecticut. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 September 1957Volume 47, Issue 3Page: 577-581KeywordsBacterial diseasesEndocarditisPenicillinProphylaxisRheumatic feverSalivaStenosisStreptococcal infectionsStreptococcusSurgery ePublished: 1 December 2008 Issue Published: 1 September 1957 PDF downloadLoading ...