tbuckley/cabot-search huggingface dataset:
Congestive Heart Failure and Diurnal Blood Pressure Pattern
Authors: Steven G. Coca, Chirag R. Parikh
Journal: JAMA (2006)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Differential Actions of Vasopeptidase Inhibition Versus Angiotensin-Converting Enzyme Inhibition on Diuretic Therapy in Experimental Congestive Heart Failure
Authors: Alessandro Cataliotti, Guido Boerrigter, Horng H. Chen, Michihisa Jougasaki, Lisa C. Costello, Toshihiro Tsuruda, Shang-Chiun Lee, Lorenzo S. Malatino, John C. Burnett
Journal: Circulation (2002)

Background — Omapatrilat (OMA), a vasopeptidase inhibitor, simultaneously inhibits angiotensin-converting enzyme (ACE) and neutral endopeptidase, which degrades vasodilatory factors (eg, ADM) and natriuretic peptides. Based on the beneficial cardiorenal and humoral properties of the natriuretic peptides, we hypothesized that an acute vasopeptidase inhibitor with or without diuretic would result in more favorable cardiorenal and hormonal actions than ACE inhibition plus diuretic (ACEI+D) in congestive heart failure. Methods and Results — We compared the actions of OMA alone and with diuretic (OMA+D) to ACEI+D in a model of pacing-induced congestive heart failure. OMA+D decreased pulmonary arterial and pulmonary capillary wedge pressures to a greater level than OMA alone or ACEI+D. Glomerular filtration rate was lower with ACEI+D than with either OMA group. Plasma renin activity and aldosterone immediately increased with ACEI+D, whereas OMA+D resulted in higher plasma renin activity and a delayed increase in aldosterone. OMA alone did not increase plasma renin activity and aldosterone, but resulted in a sustained increase in plasma adrenomedullin, with higher urinary atrial natriuretic peptide, adrenomedullin, and cGMP excretions than with ACEI+D. Conclusions — Acute administration of OMA with or without diuretic results in more favorable cardiorenal and humoral responses in experimental congestive heart failure than does ACEI+D. There is no acute activation of renin and aldosterone with OMA alone such as occurs with ACEI+D and OMA+D. Thus, OMA with or without a diuretic possesses beneficial cardiorenal and humoral actions comparable to those observed with ACEI+D that can be explained by potentiation of natriuretic peptides.
Bone regeneration performance of surface-treated porous titanium
Authors: Saber Amin Yavari, Johan van der Stok, Yoke Chin Chai, Ruben Wauthle, Zeinab Tahmasebi Birgani, Pamela Habibovic, Michiel Mulier, Jan Schrooten, Harrie Weinans, Amir Abbas Zadpoor
Journal: Biomaterials (2014)
Surgical decompression for space-occupying cerebral infarction (the Hemicraniectomy After Middle Cerebral Artery infarction with Life-threatening Edema Trial [HAMLET]): a multicentre, open, randomised trial
Authors: Jeannette Hofmeijer, L Jaap Kappelle, Ale Algra, G Johan Amelink, Jan van Gijn, H Bart van der Worp
Journal: The Lancet Neurology (2009)
PWE-185 Beliefs About Management Of Irritable Bowel Syndrome In Primary Care: Cross-sectional Survey: Abstract PWE-185 Table 1
Authors: UN Shivaji, AC Ford
Journal: Gut (2014)

<h3>Introduction</h3> There have been considerable advances in evidence synthesis concerning management of irritable bowel syndrome (IBS) in the last 5 years, with guidelines for its management in primary care published by the National Institute of Health and Care Excellence (NICE). We examined beliefs about IBS management among primary care physicians. <h3>Methods</h3> This was a cross-sectional web-based questionnaire survey of 275 primary care physicians registered with three clinical commissioning groups in Leeds, UK. We e-mailed a link to a SurveyMonkey questionnaire, containing 18 items, to all eligible primary care physicians. Participants were given 1 month to respond, with a reminder sent out after 2 weeks. <h3>Results</h3> One-hundred and two (37.1%) primary care physicians responded. Eighty-four (82.4%) of the respondents confirmed that they used clinical symptoms or signs elicited during the history and physical examination to diagnose IBS, with only 10 (9.8%) using the Rome criteria, and 4 (3.9%) the Manning criteria. A further 4 participants stated that they referred to a Gastroenterologist to confirm the diagnosis. Seventy (68.6%) primary care physicians agreed or strongly agreed that IBS was a diagnosis of exclusion, with only 5 (4.9%) strongly disagreeing with this statement. More than 80% checked coeliac serology often or always in suspected IBS. Between 56% and 76% believed soluble fibre, antispasmodics, peppermint oil, and psychological therapies were potentially efficacious therapies (table). The respondents were less convinced that antidepressants or probiotics were effective. Despite perceived efficacy of psychological therapies, 80% stated these were not easily available. Levels of use of soluble fibre, antispasmodics, and peppermint oil were in the range of 40% to &gt;50%. Most primary care physicians obtained up-to-date evidence about IBS management from NICE guidelines. <h3>Conclusion</h3> Most primary care physicians still believe IBS is a diagnosis of exclusion, and many are reluctant to use antidepressants or probiotics to treat IBS. More research studies addressing diagnosis and treatment of IBS based in primary are required. <h3>Disclosure of Interest</h3> None Declared.
Paraneoplastic cicatricial pemphigoid
Authors: None Setterfield, None Shirlaw, None Lazarova, None Bryant, None Bhogal, None Harman, None Challacombe, None Black
Journal: British Journal of Dermatology (1999)

We report a 39-year-old woman with antiepiligrin cicatricial pemphigoid (CP) in association with non-small cell carcinoma of the lung. At presentation, mucosal lesions showed minimal response to combined systemic immunosuppressive agents. Following the diagnosis of non-small cell lung carcinoma and subsequent treatment with gemcitabine (a second-line chemotherapeutic agent), a significant reduction in both tumour mass and mucosal blistering was observed. Metastatic disease was subsequently associated with recurrent oral erosions. We believe this patient represents the first reported case of paraneoplastic CP.
Running Like Water — The Omnipresence of Hepatitis E
Authors: Suzanne U. Emerson, Robert H. Purcell
Journal: New England Journal of Medicine (2004)

Hepatitis E virus (HEV), originally identified as the culprit in massive waterborne epidemics of acute hepatitis in Asia, is now commanding attention in regions of Sudan and Iraq. And once again, contaminated water is implicated. Between May and August of 2004, almost 4000 suspected cases of hepatitis E were reported by health clinics in the Greater Darfur region of Sudan, where civil conflict has forced the internal displacement of approximately 15 percent of the population. Sudanese refugees who fled to camps in neighboring Chad have fared no better, and more than 1000 suspected cases of hepatitis E were identified between . . .
David Charles Jeremy Bassett
Authors: Elisha Tikasingh
Journal: BMJ (2015)

David Charles Jeremy Bassett, bacteriologist, who worked in London, Trinidad and Tobago, Singapore and Honk Kong, died in Trinidad on March 10, 2014.

David Bassett was born to Reginald John and Pauline Margaret Bassett in Southampton, England. After graduating from high school, he took a job as laboratory technician in microbiology, after which he served with the Royal Army Medical Corps in Germany and became adept in phlebotomy. His supervisor told him one day that he was not suited for the army and that he should go to medical school. This he did, but first he attained an associateship in bacteriology from the Institute of Biomedical Sciences.

While at medical school he met and married Marilyn “Bunty” Downton, with whom he had three children. He did not like obstetrics and gynaecology and consequently did not initially pass this aspect of the programme. Funding for his medical education therefore came to an end, but he had a young family to support, so he took a job as …
IN-HOSPITAL AND LONG-TERM OUTCOME OF PRIMARY PERCUTANEOUS CORONARY INTERVENTION FOR ACUTE MYOCARDIAL INFARCTION DUE TO LEFT MAIN CORONARY ARTERY OCCLUSION
Authors: Takuya Izumikawa, Shingo Sakamoto, Satoshi Takeshita, Akihiko Takahashi, Shigeru Saito
Journal: Journal of the American College of Cardiology (2010)
Abstract 3222: Pre-clinical toxicology and pharmacology of 4-hydroperoxyifosfamide (4-HOOI) and L-lysine salt
Authors: Lee R. Morgan, Andrew H. Rodgers, Robert F. Struck, Branko S. Jursic, Gerard Bastian, William R. Waud, Chris Papiagiannis, Chris Papiagiannis
Journal: Cancer Research (2011)

Abstract HOOI is a hydroperoxy-derivative of ifosfamide (IFOS) and a pro-drug of isophosphoramide mustard (IPM) [the active metabolite of IFOS] – a bi-functional alkylator that cross-links with G/C DNA base sequences resulting in irreparable inter-strand DNA cross-linking and cell death. HOOI has been an unstable laboratory curiosity for years; however, HOOI.L-lysine is a stable salt complex that has allowed the development of HOOI for clinical trials. HOOI spontaneously releases acrolein and chloroacetaldehyde in situ in cancer cells not extracellular in the general circulation (as does IFOS) and has not been associated with cystitis, renal tubular necrosis and/or CNS toxicity. HOOI has been screened in 20+ human xenograft tumor and murine tumor models and has significantly improved %ILS in intracranially implanted human xenografts – MX-1, U251; ZR-75-1 and in P399/CPA leukemia vs. IFOS and IPM. The U251 data (%ILS – 84+) is impressive considering – BCNU produced a 72% ILS. The ZR-75-1 breast cancer had a %ILS – 83. Bone marrow failure was the DLT in mice – LD10 100 mg/kg (for M/F). Dogs (M/F) were treated with 10, 15, 20 and 30 mg/kg. For both sexes, the LD10 was calculated to be 17.2, while the LD50 was calculated to be 17.3 mg/kg. PK values in dogs revealed the following profile for groups dosed with 30 mg/kg: AUC0- t = 1.53 (mg h/L), T1/2α = 0.93 (h), T1/2β = 6.1 (h) &amp; CL = 19.5 (L/ h) [a two compartment model]. The AUC was linear for the 10 and 30 mg/kg doses. HOOI did not generate any detectable plasma chloroacetaldehyde vs. IFOS (2.12 µg/mL from 400 mg/kg) and 25% of the acrolein generated by the MTD of CPA &amp; IFOS. No convulsions, neuropathies or renal dysfunction were observed in either specie. Unlike IFOS/IPM, HOOI is lipophilic, activated intracellular (with &amp;lt; extracellular acrolein and no chloroacetaldehyde released); no IFOS/IPM-associated CNS or GU toxicity was noted. HOOI may increase the safety and efficacy margins of this class of alkylators in advanced CPA- and IFOS-resistant cancers and broaden the target-range (CNS-gliomas). The L-lysine salt stability supports developing HOOI for clinical trials. Supported by grant R44 CA094566 from the NCI/SBIR program. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 102nd Annual Meeting of the American Association for Cancer Research; 2011 Apr 2-6; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2011;71(8 Suppl):Abstract nr 3222. doi:10.1158/1538-7445.AM2011-3222
Prospects for Research for Disorders of the Endocrine System
Authors: J D Wilson
Journal: JAMA (2001)

Endocrine disorders, primarily diseases of the thyroid, parathyroids, pituitary, gonad, and adrenal glands, constitute a major health problem in all societies. As a result of improved insight into the diagnosis, pathophysiology, and molecular bases, it is now possible to diagnose the disorders earlier in their development, and the treatment of the deficiency states for most hormones is successful. Furthermore, with recognition that many of these disorders are either the consequence of single-gene mutations or have a major genetic component, it is now possible to diagnose affected fetuses and family members at risk. Therapies for the syndromes of hormone overproduction are less successful and frequently result in destruction of the endocrine organ involved, and the treatment of hormone resistance states is similarly unsatisfactory. These disorders are candidates for the development of superagonists/antagonists and gene therapies.
CD8-predominant T-cell CNS infiltration accompanies GVHD in primates and is improved with immunoprophylaxis
Authors: Saravanan Kaliyaperumal, Benjamin Watkins, Prachi Sharma, Scott Furlan, Swetha Ramakrishnan, Cynthia Giver, Anapatricia Garcia, Cynthia Courtney, Heather Knight, Elizabeth Strobert, Eric Elder, Timothy Crenshaw, Bruce R. Blazar, Edmund K. Waller, Susan Westmoreland, Leslie S. Kean
Journal: Blood (2014)
Abstract 13041: Identification of a Human Resistin Receptor That Mediates Inflammatory Actions
Authors: Sahmin Lee, Hyun-Chae Lee, Yoo-Wook Kwon, Youngjin Cho, Sang Eun Lee, Han-Mo Yang, Ju-Young Kim, Hyun-Jai Cho, Byung-Hee Oh, Young-Bae Park, Hyo-Soo Kim
Journal: Circulation (2012)

Background: Resistin is an adipokine first identified as a mediator of insulin resistance in obese mice. In human, however, resistin mainly resides in peripheral blood mononuclear cells and aggrava...
The Evolutionary Origins of Hormones, Neurotransmitters, and Other Extracellular Chemical Messengers
Authors: Howard L. Bleich, Mary Jean Moore, Jesse Roth, Derek LeRoith, Joseph Shiloach, James L. Rosenzweig, Maxine A. Lesniak, Jana Havrankova
Journal: New England Journal of Medicine (1982)

IN the past, each hormonal peptide was traditionally considered a unique product of a single cell type that was localized in distribution to a limited region of the body known as an endocrine gland (Table 1). These boundaries were too limited. For some hormones, the particular type of cells producing them were also found outside those glands. In addition, cancers derived from nonendocrine tissues, as well as diverse neurons, produce hormonal peptides.1 2 3 More recently, other cell types (non-neural and nonmalignant) have also been recognized as possible sources of peptide hormones (Table 1).Because the endocrine glands of mammals did not . . .
A REVIEW OF CANCER IN THE UNITED STATES, ACCORDING TO THE TWELFTH CENSUS.
Authors: GUTHRIE McCONNELL
Journal: JAMA (1906)

There is no question before the profession or the laity that commands so much interest and even anxiety as that of the presence and mortality of carcinoma. For many years there have been more or less sporadic efforts toward the investigation of the subject, but it is only within the last decade that serious attempts have been made in that direction. In that period various institutions have been established for the specific purpose of investigating this disease in all its relations, social, biologic, physiologic, chemic and pathologic. Although there has been no one discovery to stand forth beyond all others, yet valuable work has been done and is being done. The question was such a comparatively new one that much labor had to be expended in clearing the field from dead wood. Many ideas and theories had to be eliminated. With the field once cleared progress can be made much
Effect of protein kinase C activation on sarcoplasmic reticulum function and apparent myofibrillar Ca2+ sensitivity in intact and skinned muscles from normal and diseased human myocardium.
Authors: J K Gwathmey, R J Hajjar
Journal: Circulation Research (1990)

Protein kinase C regulates the activity of a diverse group of cellular proteins including membrane ion channel proteins. Although protein kinase C and its substrate protein have been identified in both membrane and cytosolic fractions in the heart, the physiological role of this kinase in the regulation of cardiac function remains unknown. We examined the physiological role of protein kinase C by stimulating its activity with 12-deoxyphorbol 13 isobutyrate 20 acetate (DPBA) in human trabeculae carneae. This resulted in decreased peak isometric twitch force and peak intracellular sarcoplasmic reticulum calcium release as detected with aequorin. Furthermore, in the presence of DPBA, steady-state force-[Ca2+] relations were shifted to higher intracellular calcium concentrations, and the Hill coefficient was reduced, indicating a decrease in responsiveness of the myofilaments to calcium and a change in cooperativity among thin filament proteins, respectively. Thus, DPBA affects not only intracellular calcium concentration, but myofilament calcium interactions as well. The effect of DPBA on Ca2+ activation probably reflects phosphorylation of thin-filament regulatory proteins by protein kinase C.
Diagnostic accuracy of minimally invasive markers for detection of airway eosinophilia in asthma: a systematic review and meta-analysis
Authors: Daniël A Korevaar, Guus A Westerhof, Junfeng Wang, Jérémie F Cohen, René Spijker, Peter J Sterk, Elisabeth H Bel, Patrick M M Bossuyt
Journal: The Lancet Respiratory Medicine (2015)
THE EFFECT OF ULTRAVIOLET IRRADIATION ON THE HEALTH OF A GROUP OF INFANTS
Authors: LOUIS H. BARENBERG
Journal: JAMA (1926)

The importance of sunlight for the welfare of the infant and the growing child has only recently been recognized. The favorable effect is ascribed chiefly, if not altogether, to the ultraviolet or invisible rays. As Hess<sup>1</sup>recently has pointed out, these radiations constitute less than 1 per cent of the total solar spectrum and it is therefore all the more remarkable that they should prove to be the factor essential to normal growth of the child. The effect of the ultraviolet rays in rickets in infants and animals has been investigated by many workers in this country and abroad. It has been shown objectively by means of chemical analysis of the blood and the roentgen rays that infantile rickets comes about largely from a lack of the ultraviolet solar rays and can be prevented and cured by such radiations. Recently, Eidinow<sup>2</sup>reported an increase of the normal bactericidal
167 CARDIOTROPHIN-1 (CT-1) IMPROVES SURVIVAL IN A RABBIT MODEL OF FULMINANT HEPATIC FAILURE (FHF) OF VIRAL ORIGIN
Authors: M.J. Tuñón, R. García-Lastra, I. Crespo, B. San-Miguel, M. Íñiguez, E. Larrea, I. González, I. Herrero, J. Quiroga, M. Álvarez, J. González-Gallego, J. Prieto
Journal: Journal of Hepatology (2009)
Genetic deficiency of angiotensinogen produces an impaired urine concentrating ability in mice
Authors: Minoru Kihara, Satoshi Umemura, Yoichi Sumida, Nobuyuki Yokoyama, Machiko Yabana, Nobuo Nyui, Kouichi Tamura, Kazuo Murakami, Akiyoshi Fukamizu, Masao Ishii
Journal: Kidney International (1998)
PREDICTORS OF IN-HOSPITAL MORTALITY IN A CONTEMPORARY ACUTE MYOCARDIAL INFARCTION POPULATION: RESULTS FROM THE ACTION REGISTRY-GET WITH THE GUIDELINES PROGRAM
Authors: Matthew T. Roe, Anita Y. Chen, Elizabeth DeLong, Tracy Y. Wang, John S. Rumsfeld, Christopher P. Cannon, Gregg C. Fonarow, Eric D. Peterson
Journal: Journal of the American College of Cardiology (2010)
The Lilly Lecture: Can We Prevent Heart Disease?
Authors: Lars Werkö
Journal: Annals of Internal Medicine (1970)

Meeting Abstracts1 May 1970The Lilly Lecture: Can We Prevent Heart Disease?Lars WerköLars WerköSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-72-5-775_2 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptIn order to be able to prevent disease, knowledge about the cause and pathogenesis is necessary. Some information regarding the cause of congenital heart disease, rheumatic heart disease, and some forms of arterial hypertension is available. At least some of these diseases ought to be preventable, although the knowledge has only been applied in some societies and with uncertain results.The commonest cardiovascular disorders, atherosclerosis and arterial hypertension with their various clinical manifestations, still remain etiological enigmas. Some "risk factors" have been identified that characterize the individuals who are prone to early clinical disease and premature death. Interfering with these... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Göteborg Sweden PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 May 1970Volume 72, Issue 5Page: 775-775KeywordsAtherosclerosisCardiovascular therapyCongenital heart diseaseHypertensionMedical risk factorsPathogenesis Issue Published: 1 May 1970 PDF DownloadLoading ...
Sleep and nocturnal acid reflux in normal subjects and patients with reflux oesophagitis.
Authors: N Freidin, M J Fisher, W Taylor, D Boyd, P Surratt, R W McCallum, R K Mittal
Journal: Gut (1991)

Nocturnal gastro-oesophageal reflux may be important in the pathogenesis of reflux oesophagitis. This study aimed to determine whether: (1) gastro-oesophageal reflux occurs during sleep in patients with reflux oesophagitis and, if so, to explore the mechanism, and (2) the sleep pattern of patients with oesophagitis is different from that of control subjects. After a standard evening meal, simultaneous manometric, oesophageal pH, and polysomnographic recordings were obtained in 11 patients with endoscopic oesophagitis and 11 control subjects. Patients with gastrooesophageal reflux disease had significantly more total reflux episodes throughout the nocturnal monitoring period than control subjects (105 v 6). Ninety two of 105 episodes of gastro-oesophageal reflux in patients occurred during the awake state and 10 during sleep stage II. A number of reflux episodes occurred during brief periods of arousal from the various sleep stages. Of the 105 reflux events recorded in patients, 42 were induced by transient lower oesophageal sphincter relaxation, 20 by stress reflux, 22 by free reflux mechanisms, and in 21 the mechanism was unclear. The sleep pattern and the time spent in each sleep stage was not different between the two groups. It is concluded that the awake state is crucial for the occurrence of nocturnal reflux episodes in normal subjects as well as in patients with reflux oesophagitis and that the difference between the frequency of gastro-oesophageal reflux between normal subjects and patients cannot be explained by different sleep patterns.