COMA AFTER MILTOWN OVERDOSE
Authors: B BRILL, R CHARET, C ELLOSO
Journal: Annals of Internal Medicine (1956)

Article1 December 1956COMA AFTER MILTOWN OVERDOSERICHARD CHARET, M.D., F.A.C.P., BERNARD BRILL, M.D., CIPRIANO ELLOSO, M.D.RICHARD CHARET, M.D., F.A.C.P.Search for more papers by this author, BERNARD BRILL, M.D.Search for more papers by this author, CIPRIANO ELLOSO, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-45-6-1211 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe anxiety states are so common that new sedative drugs are constantly being sought. Recently, the propanediol derivatives seemed to be among the most promising. The newest compound of this type is meprobamate (Miltown) (2-methyl-2-N-propyl-1,3-propanediol dicarbamate). The chemical was first synthesized in 1950 by Ludwig and Piech.1 The pharmacology was first described by Berger.2, 3 He demonstrated that it produces muscle relaxation and sedation through its action on the central nervous system by its inhibiting effect on the internuncial circuits. It is considered a practical, safe and clinically useful central nervous system depressant.Borrus4treated 67 patients with no ill...Bibliography1. LudwigPiech BJEC: Some anticonvulsant agents derived from 1,3-propanediols, J. Am. Chem. Soc. 73: 5779, 1951. CrossrefGoogle Scholar2. Berger FM: The pharmacological properties of 2-methyl-2-N-propyl-1,3-propanediol dicarbamate (Miltown), a new interneuronal blocking agent, J. Pharmacol. and Exper. Therap. 112: 413 (Dec.) 1954. MedlineGoogle Scholar3. HendleyLynesBerger CDTEFM: Effect of 2-methyl-2-N-propyl-1, 3-propanediol dicarbamate (Miltown) on central nervous system, Proc. Soc. Exper. Biol. and Med. 87: 608 (Dec.) 1954. CrossrefMedlineGoogle Scholar4. Borrus JC: Study of effect of Miltown (2-methyl-2-N-propyl-1, 3-propanediol dicarbamate) on psychiatric states, J. A. M. A. 157: 1596 (Apr. 30) 1955. CrossrefMedlineGoogle Scholar5. Selling LS: Clinical study of a new tranquilizing drug, J. A. M. A. 157: 1594 (Apr. 30) 1955. CrossrefMedlineGoogle Scholar6. Lemere F: New tranquilizing drugs, Northwest Med. 54: 1098 (Oct.) 1955. MedlineGoogle Scholar7. Berger FM: Personal communcation. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: *Received for publication June 5, 1956.From the Department of Medicine, Cumberland Hospital, Brooklyn, N. Y.Requests for reprints should be addressed to Richard Charet, M.D., 77 Eastern Parkway, Brooklyn 38, New York. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byAcute poisoning in a child due to the ingestion of Milprem (meprobamate and conjugated estrogens)The use of modern pharmacologic agents in psychiatric disordersCOMA DUE TO MEPROBAMATE INTOXICATION REPORT OF A CASE CONFIRMED BY CHEMICAL ANALYSISAcute Meprobamate Poisoning 1 December 1956Volume 45, Issue 6Page: 1211-1213KeywordsAllergy and immunologyCentral nervous systemComaHospital medicineIngestionMusclesPharmacologySedationSedativesUrticaria ePublished: 1 December 2008 Issue Published: 1 December 1956 PDF downloadLoading ...