tbuckley/cabot-search huggingface dataset:
Experimental Studies in Rat Lungs on the Carcinogenicity and Dose-Response Relationships of Eight Frequently Occurring Environmental Polycyclic Aromatic Hydrocarbons&lt;xref ref-type="fn" rid="FN2"&gt;2&lt;/xref&gt;&lt;xref ref-type="fn" rid="FN3"&gt;3&lt;/xref&gt;
Authors: R P Deutsch-Wenzel, H Brune, G Grimmer, G Dettbarn, J Misfeld
Journal: JNCI Journal of the National Cancer Institute (1983)

Journal Article Experimental Studies in Rat Lungs on the Carcinogenicity and Dose-Response Relationships of Eight Frequently Occurring Environmental Polycyclic Aromatic Hydrocarbons Get access Reintraud P. Deutsch-Wenzel, Reintraud P. Deutsch-Wenzel 5 5Address reprint requests to Dr. Deutsch-Wenzel, c/o Advisory Board for Preventive Medicine and Environmental Protection Ltd., Kattre-pelscrücke 1, D-2000 Hamburg 11, Federal Republic of Germany. Search for other works by this author on: Oxford Academic PubMed Google Scholar Horst Brune, Horst Brune Search for other works by this author on: Oxford Academic PubMed Google Scholar Gernot Grimmer, Gernot Grimmer Search for other works by this author on: Oxford Academic PubMed Google Scholar Gerhard Dettbarn, Gerhard Dettbarn Search for other works by this author on: Oxford Academic PubMed Google Scholar Jürgen Misfeld Jürgen Misfeld Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 71, Issue 3, September 1983, Pages 539–544, https://doi.org/10.1093/jnci/71.3.539 Published: 01 September 1983 Article history Received: 27 July 1982 Revision received: 18 April 1983 Accepted: 26 April 1983 Published: 01 September 1983
Efficacy and Safety Of Lower-Dose Glucocorticoids For Initial Treatment Of Acute Graft-Versus-Host Disease: A Randomized Controlled Trial
Authors: Marco Mielcarek, Terrence Furlong, Barry E. Storer, Margaret L. Green, Paul A. Carpenter, George B McDonald, Mary E. D. Flowers, Rainer Storb, Frederick R. Appelbaum, Michael Boeckh, Paul J. Martin
Journal: Blood (2013)
Experience of using Diaskintest by tuberculosis patients
Authors: Liudmila Pankratova, Natalia Kazimirova, Ksenia Klochkova, Margarita Ogareva
Journal: European Respiratory Journal (2012)

This is a study of Diaskintest (DST) - a new diagnostic test for tuberculosis (TB). It is an additional method of TB diagnosis and of evaluation of activity of the TB process. The objective of the study was to evaluate the sensitivity and specificity of the test on a sample of TB patients treated at the TB hospital in Saratov (Russia) in 2010 - 2012. A total of 95 subjects participated: newly diagnosed - 69.5%, with relapses - 11, 6%, chronic forms -18.9%. HIV co-infection in 22.1%.

In most TB patients (71.6%) DST was found to be positive. Test average value was 9,8 ± 8,85, including M 9,0 ± 8,21 in newly diagnosed subjects, 11,5 ± 11,71 in subjects with relapses, and 11,6 ± 9,41 in chronic patients. In subjects with limited processes, DST was 7,44 ± 4,91, and in subjects with wide-spread and destructive processes - 10,6 ± 9,77 (p ≥ 0,05). Only 42.9% subjects with HIV infection, were DST-positive. Out of the 95 participants, 27 subjects with clinically confirmed TB, 28.4% were DST-negative. Of these, 12 had HIV infection which could have caused suppression of DST sensitivity. Of the remaining 15 subjects with TB, 10 were confirmed by bacterioexretion, one – by histological examination of surgical specimens, and only 4 subjects did not have such confirmation. In other words, in 11 cases (11.6%) the presence of tuberculosis was not revealed by DST.

CONCLUSION. DST was positive in 71.6% of TB cases, but only 42.9% among HIV-positive subjects, and in 79.7% in subjects without HIV infection. In 11.6% of the cases, DST did not reveal the presence of TB.
Abstract 2575: Abnormal Regional Right Ventricular Mechanics In Acute Myocardial Infarction Without Evidence Right Ventricular Involvement by Wall Motion Analysis or Electrocardiography
Authors: Aurelio C Pinheiro, Hsin-Yueh Liang, Veronica L Dimaano, Patrick Eulitt, Mary Corretti, Steven Schulman, Theodore P Abraham
Journal: Circulation (2007)

Background: Right ventricular (RV) involvement portends a worse prognosis in acute myocardial infarction (AMI). Tissue Doppler strain echocardiography (TDSE) allows accurate, sensitive quantitation of RV mechanics. We compared TDSE to echocardiographic wall motion abnormality (WMA) and electrocardiography (EKG) in detecting RV dysfunction in AMI. Methods and Results: We prospectively imaged 55 subjects (40 consecutive patients with AMI and 15 healthy controls). All patients had troponin profiles, coronary angiography, and echocardiography and TDSE. Coronary artery stenosis &gt;70% was considered significant. We excluded 7 AMI with multiple vessel disease. We separated the rest into those with left anterior descending related AMI (LAMI) and right coronary artery related AMI (RAMI). EKG revealed RV AMI in 1 patient. None had RV WMA. RV free wall base and mid-apical segments were analyzed separately. Systolic strain (sS) and systolic (SRs) and early diastolic (SRe) strain rates were lower in RAMI compared to controls with the predominant abnormality in the basal RV with preserved mid-apical mechanics. LAMI mechanics were similar to controls except for lower SRe. Conclusions: TDSE reveals significantly abnormal RV mechanics in RAMI in the absence of WMA or RV related EKG abnormality. TDSE offers a superior alternative to EKG and conventional echocardiography for RV evaluation in AMI.
Safety of 5-grass pollen extract sublingual tablet in patients with grass pollen-induced allergic rhinoconjunctivitis and concomitant intermittent asthma: A pooled analysis
Authors: Robert K. Zeldin, Yann Amistani, Josiane Cognet-Sicé, Kathy Abiteboul
Journal: European Respiratory Journal (2013)

Background : Allergic asthma is frequently associated with grass pollen-induced allergic rhinoconjunctivitis.   Aims and objectives : To present the safety experience with the 5-grass pollen extract sublingual tablet in patients with and without asthma.   Methods : Patients with asthma controlled by GINA step 1 therapy were eligible for participation in the development program for rhinoconjunctivitis. Safety data were pooled from 8 randomised, DBPC trials: 6 natural field studies in which treatment was administered 2 or 4 months pre- and co-seasonally and 2 studies conducted outside the pollen season. Adverse events (AEs) were analysed descriptively. AE terms were screened for those suggestive of asthma (e.g. asthma, cough, dyspnoea, and wheeze). The associated AE reports were reviewed in patients with asthma at randomisation.   Results : 2200 adults and 312 children/adolescents were included in the safety database. Of these, 1514 received active treatment and 998 placebo. Asthma as an AE was reported at a similar incidence in the active (3.6%) and placebo (4.7%) groups. 425 (17%) participants had intermittent asthma at baseline. The safety profile was similar in patients with and without asthma. Overall, 99 patients with asthma (Active 53/242;22% and Placebo 46/183;25%) reported an AE of asthma or a related symptom during treatment. Three participants in the active group and 10 in the placebo group were administered oral corticosteroids as treatment for an AE suggestive of asthma.   Conclusion : The 5-grass pollen sublingual tablet has a favourable safety and tolerability profile in patients with intermittent asthma.
Psoriasis and alcohol: is cutaneous ethanol one of the missing links?
Authors: Á. Farkas, L. Kemény
Journal: British Journal of Dermatology (2009)

Many exogenous factors including excessive alcohol consumption have been associated with psoriasis, but the underlying mechanisms still remain elusive. Drinking worsens therapeutic compliance, and decreases the efficacy and increases the toxicity of systemic antipsoriatic treatments. Excess alcohol intake results in compromised immunity and increased risk of infections, but alcohol can induce proinflammatory cytokine production in various cell types and can increase mitogen-derived lymphocyte proliferation and lymphocyte activation. As we have previously reported, alcohol and one of its metabolites, acetone, induce keratinocyte proliferation and increase the mRNA levels of genes characteristic for proliferating keratinocytes, such as alpha5 integrin, cyclin D1 and keratinocyte growth factor receptor. Recently the correlation between blood and skin ethanol levels in humans was determined by a transdermal alcohol monitoring device, against the 'gold standard' breath alcohol readings. Based on transdermal alcohol measurements it can be concluded that cutaneous alcohol concentrations can reach levels that induce proinflammatory cytokine production and lymphocyte and keratinocyte proliferation in vitro. It is expected that the development of methodologies measuring transdermal ethanol will provide additional tools to evaluate how alcohol influences skin physiology and different dermatological conditions including psoriasis. Our review focuses on the possible link between alcohol misuse and psoriasis, particularly on the possible role of cutaneous ethanol in precipitating the disease.
Chemotherapy-induced insulin-dependent diabetes mellitus.
Authors: A Dispenzieri, C L Loprinzi
Journal: Journal of Clinical Oncology (1997)

Article Tools Article Tools OPTIONS & TOOLS Export Citation Track Citation Add To Favorites Rights & Permissions COMPANION ARTICLES No companion articles ARTICLE CITATION DOI: 10.1200/JCO.1997.15.3.1287 Journal of Clinical Oncology - published online before print September 21, 2016 PMID: 9060577 Chemotherapy-induced insulin-dependent diabetes mellitus. A DispenzierixA DispenzieriSearch for articles by this author , C L LoprinzixC L LoprinziSearch for articles by this author https://doi.org/10.1200/JCO.1997.15.3.1287 PDF "Chemotherapy-induced insulin-dependent diabetes mellitus.." Journal of Clinical Oncology, 15(3), p. 1287© 1997 by American Society of Clinical Oncology
Fibreoptic bronchoscopy in the management of lone pleural effusion: a negative study
Authors: P Kelly, M Fallouh, A O'Brien, L Clancy
Journal: European Respiratory Journal (1990)

In a retrospective review of 3,000 consecutive fibreoptic bronchoscopies, fifty were performed for investigation of lone pleural effusion. While 7 patients had bronchogenic carcinoma, in only one case was it visible endoscopically. In the absence of radiological or clinical features suggesting an endobronchial lesion, fibreoptic bronchoscopy is unlikely to aid in the diagnosis of lone pleural effusion.
CORTICOSTEROID-INDUCED ATROPHY OF THE SKIN WITH TELANGIECTASIA.
Authors: DANILO V. STEVANOVIC
Journal: British Journal of Dermatology (1972)

Journal Article CORTICOSTEROID‐INDUCED ATROPHY OF THE SKIN WITH TELANGIECTASIA: A CLINICAL AND EXPERIMENTAL STUDY Get access DANILO V. STEVANOVIC DANILO V. STEVANOVIC Department of Dermatology, Medical School, Belgrade, Yuguslavia Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 87, Issue 6, 1 December 1972, Pages 548–556, https://doi.org/10.1111/j.1365-2133.1972.tb07444.x Published: 01 December 1972 Article history Accepted: 20 June 1972 Published: 01 December 1972
Knowledge of inhaltation techniques among health professionals. An experience in primary care
Authors: Paula Melián, Maria Linde Reyes, Maria Eugenia Suarez, Maria Del Carmen Pacheco, Jose Luis Alonso, Maria Eugenia De La Fe
Journal: European Respiratory Journal (2013)

Introduction . In Primary Care, COPD and asthma are the most common chronic respiratory diseases. Treatment of these conditions requires patients to acquire skills in inhaler devices. Numerous studies claim that health professionals do not know the correct use of inhalation systems.   Objectives.  To assess and improve skill levels in inhalation techniques among health professionals.   Methods:  Training workshops were designed and taught by primary care and hospital nurses. Before training, participants were asked to use different inhalation systems to check their knowledge on the technique. In addition, before, after and six months from the training workshop, a 24-question multiple choice test on inhalation technique was administered.   Results : the number of professionals trained was 106 and the number of workshops 6, during 2 years. A 69.4% of the professionals initially stated that they knew the inhalation technique however previous knowledge test was not exceeded by any professional. Multiple choice test was exceeded by 32.2%, 100% and 95.1% of participants before, after and 6 months from the training workshop respectively. We found a significant relation between knowing the inhalation technique and postgraduate training or learning while developing their professional activity.   Conclusion : The professional assistants did not know the correct use of inhaler devices. After training, there is an improvement in the level of knowledge and skills in inhalation techniques that is held up 6 months later. Training workshop evaluation helps us to detect which aspects should be strengthened in this subject.
Mass Treatment With Bariatric Surgery for Type 2 Diabetes Mellitus
Authors: Maria Ida Maiorino, Giuseppe Bellastella, Katherine Esposito
Journal: JAMA Surgery (2015)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Surgery HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Surgery journal
Quantitative immunohistochemical differences between catalase and thioredoxin in different anatomic compartments of the lung in severe COPD
Authors: Daniel Popa, Gustaf Lejonberg, Jonas Erjefält, Beata T. Olejnicka
Journal: European Respiratory Journal (2014)

Extensive evidence indicates that tobacco smoke-induced COPD is associated with an altered cellular redox state and an uncontrolled immune-inflammatory response in a genetically susceptible host. Catalase (CAT) is a primary-line antioxidant and the scavenging thioredoxin (TRX) system plays a decisive role in the maintenance of a reduced intracellular redox state. AIMS investigates the density of immunoreactivity to CAT/TRX and the interrelationship between inflammatory profiles, destructive(DI)/proliferative index (PI) in severe COPD.

Immunocytochemistry was performed using paraffin-embedded sections from controls (non-smokers), and subjects with very severe COPD. Quantitative differences in the distribution of macrophages (MQ), neutrophils, CAT/TRX were analyzed in the same Region-of-Interset (ROI) in three different anatomical compartments: small airways, peripheral pulmonary artery, and alveolar parenchyma for each subject.

A moderate CAT immunostaining in the luminal bronchiolar epithelium and stronger immunostaining in SMM was observed in the COPD group. The intensity of CAT-staining showed a positive correlation between histological neutrophils reactions/PI mostly in alveolar parenchyma. The percentage of TRX immunoreactivity was significantly higher in bronchiolar epithelium and moderate in bronchiolar adventitial compartments. In contrast, the TRX-immunostaing was weak in tunica intima but significantly greater in adventitia.

In summary, the intensity of positive staining of adventitial compartments/SMM regions was significantly higher for both CAT and TRX; moreover CAT staining positively correlates with neutrophils.
LSC 2014 abstract - A20 levels in dendritic cells control eosinophilic versus neutrophilic lung inflammation in asthma
Authors: Heleen Vroman, Ingrid M. Bergen, Geert van Loo, Rudi W. Hendriks, Bart N. Lambrecht, Bernt van den Blink, Mirjam Kool
Journal: European Respiratory Journal (2014)

Asthma is a chronic inflammatory disease of the airways in response to inhaled antigens such as house dust mite (HDM). Classically asthma is characterized as Th2 mediated disease with eosinophilic inflammation as seen in mild to moderate asthma. However, Th17-mediated neutrophilic inflammation is observed in severe steroid-resistant asthma. Dendritic cell (DC) activation is known to control Th2 and Th17 differentiation from naive T cells. Activation of DCs is tightly regulated by A20, a negative regulator of NF-kappaB pathway.

To investigate whether A20 levels in DCs are important for the differentiation of naive T cells and the asthmatic immune response, we used mice that lacked A20 expression specifically in DCs (A20fl/fl Cd11c Cre+ mice; DC-A20 mice) and exposed them to our HDM-driven model for asthma. Mice were sensitized with 1 µg HDM or PBS and challenged with 10 µg HDM.

Exposure of DC-A20WT mice to HDM induced a Th2-mediated eosinophilic inflammation, goblet cell hyperplasia and expression of IL-5 and IL-13 by CD4 T cells. In contrast, DC-A20KO mice showed a Th17-mediated neutrophilic inflammation, IL-17A expression by CD4 T cells and no mucus production. DC-A20HZ mice showed a combined inflammation of eosinophils and neutrophils, and CD4 T cells expressed IL-5 and IL-13 as well as IL-17A, indicative of a mixed Th2/Th17 response.

This study shows that A20 levels in DCs directly control the inflammatory response and thereby asthma severity. It was decisive for eosinophilic versus neutrophilic inflammation and could offer a new starting point for therapies for severe asthma patients.
Electronic patient record as a facilitator to guideline based asthma management
Authors: Jean Holohan, Louis Coyne, Francis Guiney, Pat Manning, Basil Elnazir, Eamonn Shanahan, Terry O'Connor, Muireann Ni Chroinin, Netta Williams, Rhonda Forsythe, Pamela Logan
Journal: European Respiratory Journal (2011)

Prior to the initiation of this project there was no consistent guideline based approach to an asthma consultation in primary care in Ireland. There is a variety of practice management systems but no consistent asthma module leading to variations in asthma management.  The Asthma Society of Ireland (ASI) collaborated with the Irish College of General Practitioners (ICGP) to develop locally modified GINA Guidelines as an initial step to developing an asthma specific Electronic Patient Record (EPR). The EPR was tested in 25 primary care sites; attitudes towards the EPR were evaluated using a 5 point Likert Scale.  The EPR captured demographic data, guided the consultation along a guideline based pathway through diagnosis, lung function tests, evaluation of asthma control according to GINA status, recorded medication and flu vaccinations, aided treatment selection in a step by step approach, identified patient educational priorities and objectives for next consultation. Data could be extracted to form a standardised referral letter to A&E or consultant. It provided a platform to develop personal action plans for the patient.  Healthcare professionals (HCP) found the EPR easy to use (65%). EPR aids diagnosis (68%), assessment (90%), treatment selection (82.5%), and monitoring control (80%), facilitates patient education (85%) and helps with development of personal action plans (65%).  HCP in primary care agreed that an asthma specific EPR facilitates guideline based asthma management. This EPR will provide the template for an asthma module in practice management systems in Ireland and ASI has engaged with stakeholders on the module development.
Long-Term Disease-Free Survivors in Metastatic Undifferentiated Carcinoma of Nasopharyngeal Type
Authors: Abderrahim Fandi, Mounir Bachouchi, Nacer Azli, Abdelkrim Taamma, Hammouda Boussen, Pierre Wibault, François Eschwege, Jean-Pierre Armand, Jonathan Simon, Esteban Cvitkovic
Journal: Journal of Clinical Oncology (2000)

To review incidence and analyze profile of long-term complete responders among patients with undifferentiated carcinoma of nasopharyngeal type (UCNT) treated at a single institution.We present a cohort of 20 long-term unmaintained complete responders to chemotherapy for metastatic UCNT treated at the Institut Gustave Roussy between April 1978 and November 1996. A patient was considered a long-term survivor if he or she was disease-free for more than 36 months without treatment after obtaining a complete response by chemotherapy. Patient characteristics were as follows: sex, 17 men and three women; median age, 28 years (range, 9 to 62 years); median World Health Organization performance status, 1; and initial tumor-node-metastasis stage (International Union Against Cancer-American Joint Committee on Cancer, 1987) of T3 to T4, 60%, and of N2b to N3, 75%. Epstein-Barr virus serology was characteristic in 19 patients. Of 16 pretreated patients, 11 were pretreated by radiotherapy alone and five by chemotherapy and radiotherapy. Thirteen patients had metastatic relapses of locally controlled UCNT. Tumor sites were bone in 15 patients, lung in four, and liver (biopsy-proven) in two. Chemotherapy included the following: cisplatin, bleomycin, and fluorouracil in five patients; bleomycin, epirubicin, and cisplatin in seven patients; fluorouracil, mitomycin, epirubicin, and cisplatin in four patients; and fluorouracil, bleomycin, epirubicin, and cisplatin in one patient. Three patients were treated with platinum-based regimens before 1985. Patients received a median of six cycles (range, three to 13). Thirteen patients with bone metastases received consolidating radiotherapy.As of June 1999, 14 of 20 patients were still alive with no evidence of disease after treatment (disease-free survival time, 82+ to 190+ months), three patients died of other causes while in complete response at 61, 109, and 208 months after treatment, and three patients died of disease at 42, 89, and 115 months after treatment. Long-term complete responses were obtained in both bone and visceral disease.Our data support a curative role for chemotherapy in metastatic UCNT and are a major incentive to continue research for better combinations to increase the percentage of patients with metastatic UCNT who attain complete responses and long-term survival.
“Feeding the Baby”-Designing the Culture Milieu to Enhance Cell Stability1
Authors: Charity Waymouth
Journal: JNCI Journal of the National Cancer Institute (1974)

Attention was drawn to the responsiveness of cells, in vivo and in vitro, to small changes in their environment. Some of the more important, and the more often neglected, influences of the milieu on the genotypic and phenotypic stability and instability of cells in vitro were reviewed. Among the factors affecting one or more forms of cell stability were microorganisms (sometimes unrecognized), serum proteins, enzymes, cations, ionic balance and pH, O2 tension, hormones, and macromolecular growth .factors. It was suggestedthat high priority should be given to the design of defined milieus for enhancing the genotypic and phenotypic stability of specific cell types, and to the elimination of the hazards, variabilities, and uncertainties associated with the use of serum in culture media.