Methotrexate and Rheumatoid Arthritis
Authors: William S. Wilke, Joel M. Kremer, Allen M. Mackenzie, Allen M. Segal, Daniel J. Mazanec, Anna P. Koo, Leonard H. Calabrese, Raymond J. Scheetz, Constance S. White, John D. Clough
Journal: Annals of Internal Medicine (1989)

Letters and Corrections1 January 1989Methotrexate and Rheumatoid ArthritisWilliam S. Wilke, MD, Joel M. Kremer, MD, Allen M. Mackenzie, MD, Allen M. Segal, DO, Daniel J. Mazanec, MD, Anna P. Koo, MD, Leonard H. Calabrese, DO, Raymond J. Scheetz, MD, Constance S. White, MD, John D. Clough, MDWilliam S. Wilke, MDSearch for more papers by this author, Joel M. Kremer, MDSearch for more papers by this author, Allen M. Mackenzie, MDSearch for more papers by this author, Allen M. Segal, DOSearch for more papers by this author, Daniel J. Mazanec, MDSearch for more papers by this author, Anna P. Koo, MDSearch for more papers by this author, Leonard H. Calabrese, DOSearch for more papers by this author, Raymond J. Scheetz, MDSearch for more papers by this author, Constance S. White, MDSearch for more papers by this author, John D. Clough, MDSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-110-1-88_2 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the Editor: We were pleased to read the review on methotrexate treatment for rheumatoid arthritis by Tugwell and associates (1) and the position paper of the American College of Physicians (2). We agree that it is prudent to adopt a conservative position about the use of methotrexate for treating patients with rheumatoid arthritis. We feel that it is important that the drug be administered safely.The position paper recommends that methotrexate be administered in pulse fashion once weekly but in three divided doses 12 hours apart. We disagree with this recommendation.The divided-dose regimen for the use of methotrexate...References1. TugwellBennettGent PKM. Methotrexate in rheumatoid arthritis: indications, contraindications, efficacy, and safety. Ann Intern Med. 1987;107:358-66. LinkGoogle Scholar2. . Methotrexate in rheumatoid arthritis. Ann Intern Med. 1987;107:418-9. LinkGoogle Scholar3. KremerJoong JK. The safety and efficacy of the use of methotrexate in long-term therapy for rheumatoid arthritis. Arthritis Rheum. 1986;29:822-31. CrossrefMedlineGoogle Scholar4. KremerGalivanStreckfussKamen JJAB. Methotrexate metabolism analysis in blood and liver of rheumatoid arthritis patients: association with hepatic folate deficiency and formation of polyglutamates. Arthritis Rheum. 1986;29:832-5. CrossrefMedlineGoogle Scholar5. RoenigkAuerbachBergfeld HRW. A cooperative, prospective study of the effects of chemotherapy of psoriasis on liver biopsies. In: Farber, Cox, eds. Psoriasis Proceedings: 2nd Internationnal Symposium. New York: New York Medical Books; 1977:243-8. Google Scholar1. . Methotrexate in rheumatoid arthritis. Ann Intern Med. 1987;107:418-9. LinkGoogle Scholar2. TugwellBennettGent PKM. Methotrexate in rheumatoid arthritis: indications, contraindications, efficacy, and safety. Ann Intern Med. 1987;107:358-66. LinkGoogle Scholar3. Frank S. Pulmonary dysfunction in rheumatoid disease. Chest. 1973;67:27-34. CrossrefGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byMethotrexate in Rheumatoid Arthritis Feedback on American College of Physicians GuidelinesPeter Tugwell, MD, Kathryn Bennett, MSc, Mary Bell, MD, Michael Gent, MD 1 January 1989Volume 110, Issue 1Page: 88-90KeywordsDrugsHeart rateMethotrexateRheumatoid arthritis ePublished: 1 December 2008 Issue Published: 1 January 1989 PDF downloadLoading ...