tbuckley/cabot-search huggingface dataset:
Immunosuppressive Therapy for Factor VIII Inhibitors
Authors: Robert W. Colman
Journal: Annals of Internal Medicine (1990)

Letters and Corrections1 February 1990Immunosuppressive Therapy for Factor VIII InhibitorsRobert W. Colman, MDRobert W. Colman, MDSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-112-3-233_1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the Editor:Lian and colleagues (1) reported 12 patients and reviewed the literature for the use of combination immunosuppressive therapy and factor VIII administration to treat FVIII antibodies. They credited Green (2) with originating the idea that patients will respond to steroids or cytotoxic agents or both after factor VIII concentration is infused. The rationale that Green (2) promulgated is that factor VIII stimulates the antibody-producing cells, allowing more effective killing of cells by cytotoxic agents. However, the authors neglected a study in which I participated (3), which appeared in 1970, 1 year before Green's article. We treated two...References1. LianLarcadaChiu EAA. Combination immunosuppressive therapy after factor VIII infusion for acquired factor VIII inhibitor. Ann Intern Med. 1989;110:774-8. LinkGoogle Scholar2. Green D. Suppression of an antibody to factor VIII by a combination of factor VIII and cyclophosphamide. Blood. 1971;37:381-7. CrossrefMedlineGoogle Scholar3. RobboyLewisSchurColman SEPR. Circulating anticoagulants to factor VIII: immunochemical studies and clinical response to factor VIII concentrates. Am J Med. 1970;49:742-52. CrossrefMedlineGoogle Scholar4. DvorakFlax HM. Immunologic unresponsiveness in the adult guinea pig. II. The kinetics of unresponsiveness. J Immunol. 1966;96:546. MedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: Robert W. Colman, MDAffiliations: Temple University School of Medicine Philadelphia, PA 19140 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 February 1990Volume 112, Issue 3Page: 233-233KeywordsAntibodiesAttentionCellsCytotoxinsHomicideImmunosuppressivesSteroids ePublished: 1 December 2008 Issue Published: 1 February 1990 PDF downloadLoading ...
Clinical significance of the ubiquitin ligase UBE3C in hepatocellular carcinoma revealed by exome sequencing
Authors: Jia-Hao Jiang, Yan-Feng Liu, Ai-Wu Ke, Fang-Ming Gu, Yao Yu, Zhi Dai, Qiang Gao, Guo-Ming Shi, Bo-Yi Liao, You-Hua Xie, Jia Fan, Xiao-Wu Huang, Jian Zhou
Journal: Hepatology (2014)

Virus-induced hepatocarcinogenesis involves a series of histological developmental processes with the stepwise acquisition of several genetic changes that are necessary for the malignant transformation of hepatocytes. Although genetic alterations are known to be involved in the pathogenesis of hepatocellular carcinoma (HCC), little is known about the contributions of specific genes to this process. To gain insight into the genetic alterations involved in the neoplastic evolution from chronic hepatitis B virus infection to dysplastic nodules (DN) to HCC, we captured and sequenced the exomes of four DNA samples: one DN sample, two HCC samples, and one control peripheral blood sample from a single HCC patient. Mutations in the UBE3C gene (encoding ubiquitin ligase E3C) were observed in both tumor tissues. Then we resequenced the UBE3C gene in a cohort of 105 HCC patients and identified mutations in 17 out of a total of 106 (16.0%) HCC patients. The subsequent experiments showed that UBE3C promoted HCC progression by regulating HCC cells epithelial-mesenchymal transition. Clinically, a tissue microarray study of a cohort containing 323 HCC patients revealed that the overexpression of UBE3C in primary HCC tissues correlated with decreased survival (hazard ratio [HR] = 1.657, 95% confidence interval [CI] = 1.220-2.251, P = 0.001) and early tumor recurrence (HR = 1.653, 95% CI = 1.227-2.228, P = 0.001) in postoperative HCC patients. Conclusion : Our findings indicate that UBE3C is a candidate oncogene involved in tumor development and progression and therefore a potential therapeutic target in applicable HCC patients. (Hepatology 2014;59:2216–2227)
"The Facts Concerning the Recent Carnival of Smoking in Connecticut" and Elsewhere
Authors: Geoffrey C. Williams
Journal: Annals of Internal Medicine (1991)

▪ The behavior of health care practitioners toward their patients can greatly affect the patients' motivation for change. Mark Twain's story, "The Facts Concerning the Recent Carnival of Crime in Connecticut," is used to illustrate how traditional strategies for motivating patients to change can have the paradoxic effect of inhibiting change and growth. We use a theory of human motivation, referred to as self-determination theory, to explain this effect and suggest alternative strategies for facilitating patient motivation. Empirical tests of the theory have shown that people will accept more responsibility for behavior change when motivated internally rather than externally. In the doctor-patient relationship, this internal motivation for change can be faciliated when doctors allow choice, provide relevant information, and acknowledge the patient's perspective. We propose a simple, three-question model, consistent with self-determination theory, for physicians to use with patients who smoke and are not yet ready to try quitting.
Effect of Eradication of<i>Helicobacter pylori</i>in Patients with Fundic Atrophic Gastritis
Authors: Antonio Tucci, Guido Biasco, Giovanni Francesco Paparo
Journal: New England Journal of Medicine (1997)

To the Editor: Nonautoimmune atrophic gastritis of the fundus is commonly considered chronic, progressive, and irreversible and is closely associated with gastric carcinoma and endocrine-cell tumor...
How Serious Is the Indoor Radon Health Hazard?
Authors: Marsha F. Goldsmith
Journal: JAMA (1987)

"YOU PAYS YOUR money and you takes your choice"—or chance, as the case may be. Where radon is involved, it is hard to say just what one ought to do. Some persons apparently are convinced that exposure to this radioactive decay product of uranium is good for what ails them. (See photo.) But substantially more people seem to be concerned that radon is yet another thing to add to the list of modern woes that may do civilization in. While cure seekers apparently skeptical of legitimate medicine pay up to $4 per hour to partake of the putative benefits of radon gas in played-out uranium mines in the west, many Americans on the eastern seaboard and elsewhere, also with good health in mind, spend thousands of dollars to rid their own homes of the very same effusion. No medical authority advocates a retreat to the cave. But modern housing is
Recent Developments in Metabolism That Impinge on Research into the Nature and Treatment of Diabetes Mellitus
Authors: Eric A Newsholme
Journal: Diabetes Care (1992)

It has been established that adenosine, its agonists, or antagonists can cause dramatic changes in insulin sensitivity in isolated soleus muscle and, moreover, can modify changes in sensitivity caused by pathophysiological conditions. Addition of adenosine deaminase to the incubation medium, which is known to lower the concentration of adenosine, increases the sensitivity of glycolysis to insulin. Addition of an adenosine-receptor agonist decreases sensitivity by about 10-fold, whereas addition of an adenosine-receptor antagonist increases sensitivity by about 10-fold. The latter totally removes the resistance of glucose utilization to insulin in the isolated soleus muscle obtained from either the genetically obese rat or from the rat fed a high sucrose diet. These findings strongly support the view that changes in insulin sensitivity in muscle can be brought about either by acute changes in the local concentration of adenosine or in the affinity or number of receptors for adenosine in muscle. However, in many of the conditions investigated, in which insulin sensitivity in muscle is changed, there was no correlation between the change in the adenosine content of the muscle and altered insulin sensitivity. It has also been shown that prostaglandin E1 can increase dramatically the sensitivity of glycolysis to insulin and that this is a specific effect of prostaglandins of the E series. It is not produced by prostacyclins, thromboxanes, or leukotrienes. It is unclear if there is a relationship between the effects of adenosine and prostaglandins. Chronic elevation of catecholamines may increase the sensitivity of glucose utilization to insulin and also increase the rate of thermogenesis by substrate cycling. Thus, resistance to catecholamines in muscle could result in both insulin resistance and impaired thermogenesis. Recent work has emphasized the important role of glutamine in the immune system, yet little or no work has been done on glutamine metabolism in diabetes mellitus.
TREATMENT OF PROSTATIC HYPERTROPHY.
Authors: PARKER SYMS
Journal: JAMA (1901)

Prostatic hypertrophy causes misery to a large proportion of men in advanced life, and results in such serious consequences that we must welcome every effort that is made to our means of curing or relieving its unfortunate victims. Fortunately much has been accomplished in this direction of late, and the author wishes to take this opportunity to present a new device that aids in the operation for radical cure. When the prostate gland becomes enlarged it sooner or later acts as an impediment to the emptying of the bladder. In some cases it causes but little obstruction; in others it prevents the passage of the urine till the bladder is filled and distended, when the urine may constantly overflow by dripping, which is a condition often mistaken for incontinence of urine; or the bladder may be partially emptied by the act of urination, but it can not expel the last
Oral Fluoroquinolone Therapy in Clostridium difficile Enterocolitis
Authors: Ludwig A. Lettau
Journal: JAMA (1988)

<h3>To the Editor.—</h3> <i>Clostridium difficile</i>infection is the most common cause of antibiotic-associated enterocolitis. In their response to a question regarding treatment of<i>C difficile</i>disease in a recent issue ofThe Journal, Drs Gebhard and Gerding recommend treatment with oral vancomycin or metronidazole if the patient has significant symptoms.<sup>1</sup>Such treatment is even more urgent when the implicated antibiotic (or other antibiotic therapy of the primary infection) cannot be stopped. We report two patients with bone and joint infections in whom<i>C difficile</i>toxin-positive diarrhea developed during therapy with ceftriaxone and resolved after simply changing to oral ciprofloxacin therapy. <h3>Report of Cases.—</h3> Case1.—A 74-year-old man with lumbar osteomyelitis due to<i>Escherichia coli</i>(confirmed by needle aspiration) was treated with ceftriaxone, 2 g intravenously daily. After four weeks of therapy and significant symptomatic improvement, it was elected to change therapy to ciprofloxacin, 750 mg orally twice daily. Because
Low Sodium Intake — Cardiovascular Health Benefit or Risk?
Authors: Suzanne Oparil
Journal: New England Journal of Medicine (2014)

Hypertension is the most common modifiable risk factor for cardiovascular disease and death. Worldwide, it is estimated that more than 1 billion adults have hypertension, that this figure is projected to climb to 1.5 billion by the year 2025, and that hypertension accounts for more than 9 million deaths annually.1,2 Because of its high prevalence and related morbidity and mortality, population-wide approaches to reducing blood pressure, and therefore the burden of cardiovascular disease, have been recommended. Among these strategies, reducing dietary sodium and, to a lesser extent, increasing dietary potassium have been included in many guidelines for the treatment . . .
Elevation of beta-adrenergic receptor density in human lymphocytes after propranolol administration.
Authors: R D Aarons, A S Nies, J Gal, L R Hegstrand, P B Molinoff
Journal: Journal of Clinical Investigation (1980)

Abrupt withdrawal after the chronic administration of propranolol has resulted in clinical syndromes that suggest adrenergic hypersensitivity. The effect of propranolol administration and withdrawal on beta-adrenergic receptors was studied in human lymphocyte membranes. Receptor density was quantitated by direct binding assays with the radioligand [125I]iodohydroxybenzylpindolol. Administration of propranolol (160 mg/d) for 8 d resulted in trough plasma levels of approximately 35 ng/ml. By day 5 of propranolol administration the density of beta-adrenergic receptors had increased 43 +/- 4% (P less than 0.01) above pretreatment levels. Abrupt withdrawal of propranolol was followed by the disappearance of propranolol from the plasma within 24 h. The density of beta-adrenergic receptors did not return to pretreatment level for several days. Physiologic supersensitivity of beta-adrenergic receptor-mediated responses was suggested by the appearance of significant increases in the orthostatic change in heart rate (P less than 0.05) and the orthostatic change in the heart rate-systolic blood pressure product (P less than 0.01) during the first 48 h after propranolol withdrawal. These data show that propranolol administration leads to an increase in the density of beta-adrenergic receptors in human tissue. The results are consistent with the hypothesis that some of the untoward effects observed after abrupt discontinuation of propranolol are caused by beta-receptor-mediated adrenergic hypersensitivity.
Matrix Metalloproteinase-9 from Bone Marrow–Derived Cells Contributes to Survival but not Growth of Tumor Cells in the Lung Microenvironment
Authors: Heath B. Acuff, Kathy J. Carter, Barbara Fingleton, D. Lee Gorden, Lynn M. Matrisian
Journal: Cancer Research (2006)

Abstract The role of specific stromal-derived matrix metalloproteinases (MMPs) was analyzed in experimental metastasis assays in wild-type and either MMP-9, MMP-7, or MMP-2 null mice. MMP-9 null mice showed an 81% reduction in Lewis lung carcinoma tumor number, whereas MMP-7 null mice showed a 42% increase in tumor number, and there was no difference in tumor number in MMP-2 null mice compared with wild-type controls. Similarly, in an orthotopic model of lung cancer, 50% fewer MMP-9 null mice were able to establish tumors in the lung compared with control mice, although the size of the tumors was not different. The effect of MMP-9 on lung tumor colonization was dependent on the expression of MMP-9 from bone marrow–derived cells and is most likely contributed by neutrophils. To examine temporal effects of stromal MMP-9, bioluminescence imaging from luciferase-expressing human lung cancer–derived A549 cells revealed that there were fewer tumor cells in the lungs of MMP-9 null mice as early as 19 hours after injection compared with control mice, with no difference in subsequent growth rates. Six hours after injection of tumor cells, MMP-9 null mice showed a 4-fold increase in the percent of tumor cells undergoing apoptosis compared with control mice. We conclude that MMP-9 from the bone marrow contributes to the early survival and establishment of tumors in the lung and has no effect on subsequent growth. These results provide insights into the failure of MMP inhibitors in clinical trials in patients with late-stage lung cancer. (Cancer Res 2006; 66(1): 259-66)
The Infant at Risk
Authors: Ann Maravilla
Journal: JAMA (1975)

This is a collection of papers presented in early 1973 at a symposium sponsored by the National Foundation March of Dimes. Its purpose was to bring together child-health workers from the fields of medicine, psychiatry, nutrition, and social sciences to study the environmental factors that affect the child from conception to 4 years of age, and to find ways to favorably alter that environment. The introductory paper by Robert Coles, MD, gives the reader insight into the daily life and coping mechanisms of a southern black child. The following papers are then grouped into subsections. Three papers deal with pregnancy and the perinatal period. They are filled with good hard data and highlight the complexity and variety of environmental interactions. A subsection on "Early Emotional-Psychologic Development" has an excellent paper on individual differences in personality and its affects on the interaction with the mother. The author shows how a satisfactory
Panniculitis and Systemic Lupus Erythematosus
Authors: Richard K. Winkelmann
Journal: JAMA (1970)

Three cases of systemic lupus erythematosus and panniculitis illustrate the inflammatory, sclerotic, and ulcerative clinical features of the skin lesions. Histopathologic diagnosis is characterized by poikiloderma, lymphocytic inflammation, hyaline necrosis of collagen and fat, and focal calcification. The lesions respond to antimalarial and corticosteroid therapy, and full-thickness skin grafts are well tolerated. The differential diagnosis includes other forms of panniculitis and localized scleroderma.
Breast Lumps-Reply
Authors: Charles Eckert
Journal: JAMA (1976)

In Reply.—  In response to Dr Rosier's statement concerning the frequency of cells in the aspirate of breast  I would repeat that under the conditions described, the fluid has, in my experience, been acellular. These conditions include the absence of blood in the aspirate and no residual palpable mass following the completion of aspiration and at subsequent reexamination three weeks and three months later. Furthermore, microscopic sections of so-called  cysts are lined by a single layer of flattened epithelial cells, with little evidence of significant desquamation into the cyst cavity. Malignant cysts are infrequent, and the fluid has invariably been bloody.  Infrequently, small cancers have unexpectedly been found adjacent to blue-domed cysts, but this happenstance is not a justification for excisional biopsy.  Dr Rubenstein has quoted a thoughtful editorial by Dr Johnson concerning the value of preoperative mammography in determining the need for preoperative evaluation of the skeletal
INTRATYMPANIC SURGERY; ESPECIALLY IN CHRONIC PURULENT OTITIS MEDIA.
Authors: CHARLES HENRY BURNETT
Journal: JAMA (1898)

My experience in intratympanic surgery has been gained in 109 operations within the drum cavity, viz.: 43 operations for the relief of chonic catarrhal deafness and tinnitus, 26 for the relief of chronic tinnitus and tympanic vertigo (Ménière's symptoms) of catarrhal origin, and 30 for the relief of chronic purulency of the middle ear. In this article, however, I shall ask your attention to brief notes of the thirty purulent cases and the operations performed for the relief of this diseased condition of the ear. In all these cases various rational routine means had been employed for their amelioration before resorting to intratympanic operations. These operations have been performed upon the etherized patient, with one exception, Case 8, in which the dangling malleus was removed like a polypus with the polypus snare. The ear has been illuminated by means of a three-candlepower electric head lamp, held on the forehead, like
Resistance of clinical isolates of Haemophilus influenzae.
Authors: A J Howard
Journal: BMJ (1987)

who, like myself, have carried out this procedure uneventfully in patients with values of less than 1 litre.Other factors should also be considered, including the presence of airway lability, respiratory failure, and exercise tolerance.Of course, Drs S P Ruffles and J G Ayres were correct to perform bronchoscopy on their patient.It is sim- plistic to suggest that the search for a bronchial carcinoma should be curtailed because the patient would not be a candidate for surgery.
Thiazides increased hyponatremia, but not hospitalizations, in patients with hypertension
Authors: Jose M. Villalon-Gomez
Journal: Annals of Internal Medicine (2012)

ACP Journal Club17 April 2012Thiazides increased hyponatremia, but not hospitalizations, in patients with hypertensionJose M. Villalon-Gomez, MD, MPHJose M. Villalon-Gomez, MD, MPHFloyd Family Medicine Residency Program, Rome, Georgia, USA (J.M.V.)Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-156-8-201204170-02011 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail Source CitationLeung AA, Wright A, Pazo V, Karson A, Bates DW. Risk of thiazide-induced hyponatremia in patients with hypertension. Am J Med. 2011;124:1064-72. https://pubmed.ncbi.nlm.nih.gov/22017784Clinical Impact RatingsGIM/FP/GP: Hospitalists: References1 Wright JM, Musini VM. First-line drugs for hypertension. Cochrane Database Syst Rev. 2009:CD001841. [PMID: 19588327] Google Scholar2 Clayton JA, Rodgers S, Blakey J, Avery A, Hall IP. Thiazide diuretic prescription and electrolyte abnormalities in primary care. Br J Clin Pharmacol. 2006;61:87-95. [PMID: 16390355] Google Scholar Author, Article, and Disclosure InformationAffiliations: Floyd Family Medicine Residency Program, Rome, Georgia, USA (J.M.V.)This article was published at Annals.org on 3 April 2012. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByParallel-Group 8-Week Study on Chlorthalidone Effects in Hypertensives With Low Kidney Function 17 April 2012Volume 156, Issue 8Page: JC4-11KeywordsCohort studiesDiureticsDrugsHospitalizationsHypertensionHyponatremiaResearch laboratoriesStatistical dataTherapeutic drug monitoring ePublished: 17 April 2012 Issue Published: 17 April 2012 CopyrightCopyright © 2012 by American College of Physicians. All Rights Reserved.PDF DownloadLoading ...
'Beverly Hills, 90210': The Lap Belts Don't Show on TV-Reply
Authors: Charles Rosin
Journal: JAMA (1992)

<h3>In Reply.</h3> —As the executive producer of a television show that seven of 10 teenage girls who are television viewers tune to any Thursday night, no one is more aware of the impact that our series has on this impressionable segment of the viewing audience. That is why the National Association of Social Workers, the Center for Population Options, the National Conference of Christians and Jews, and the American Red Cross have recognized our series for tackling such subjects as teenage sexuality, substance abuse, and race relations in a mature and responsible manner. And that is why in every scene in which anyone is shown driving a car, the characters are also wearing seat belts. Perhaps the reason that Drs Hamilton and Goldhaber thought otherwise is that our two prime show vehicles, a 1967 Mustang and a 1972 Porsche, are classic cars that are equipped only with lap belts that,
The mysterious Dr Foster
Authors: N. Hawkes
Journal: BMJ (2009)

Thank you for your interest in spreading the word about The BMJ.NOTE: We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail. We do not capture any email address. Username * Your Email * Send To * You are going to email the following The mysterious Dr Foster Your Personal Message CAPTCHA This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
Case 47-1987
Authors: Richard C. Cabot, Robert E. Scully, Eugene J. Mark, William F. McNeely, Betty U. McNeely, Roger J. May, Carolyn C. Compton
Journal: New England Journal of Medicine (1987)

Presentation of CaseA 79-year-old woman was admitted to the hospital because of vomiting and weight loss.There was a history of hypertension, for which she received no treatment recently. Asthma was present for the preceding eight years and was managed with prednisone given daily in an unknown dose. She was well in other respects until 3 1/2 months before admission, when she was brought to this hospital because of a severe headache and changed mental status. The temperature was 39.2°C. She was obtunded, without meningeal signs. A macular erythematous eruption was observed over the abdomen. A lumbar puncture yielded . . .