Intrahepatic Cholestatic Jaundice of Pregnancy Followed by Enovid-induced Cholestatic Jaundice
Authors: WILLIAM C. BOAKE
Journal: Annals of Internal Medicine (1965)

Case Studies1 August 1965Intrahepatic Cholestatic Jaundice of Pregnancy Followed by Enovid-induced Cholestatic JaundiceReport of a CaseWILLIAM C. BOAKE, M.D., STANLEY G. SCHADE, M.D., JOHN F. MORRISSEY, M.D., FENTON SCHAFFNER, M.D., F.A.C.P.WILLIAM C. BOAKE, M.D.Search for more papers by this author, STANLEY G. SCHADE, M.D.Search for more papers by this author, JOHN F. MORRISSEY, M.D.Search for more papers by this author, FENTON SCHAFFNER, M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-63-2-302 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptJaundice, often recurring in successive pregnancies and characterized by intrahepatic cholestasis with few if any parenchymal liver changes, has been frequently observed in Scandinavia (1, 2) but less frequently observed in the United States (3). This condition, which generally occurs in the last 4 months of pregnancy, is not, however, rare and has been reported in many countries (4), having been usually entitled "recurrent jaundice of pregnancy" or "idiopathic jaundice of pregnancy." The jaundice, which is accompanied and often preceded by pruritus, disappears shortly after delivery. It is not caused by hepatitis, hepatic necrosis, or excessive hemolysis, but the biochemical...References1. THORLING L: Jaundice in pregnancy. Acta Med. Scand. (suppl.) 302: 1, 1955. Google Scholar2. SVANBORGOHLSSON AS: Recurrent jaundice of pregnancy: a clinical study of 22 cases. Amer. J. Med. 27: 40, 1959. CrossrefMedlineGoogle Scholar3. BROWNPORTERREDER DFEAJ: Idiopathic jaundice of pregnancy. Arch. Intern. Med. (Chicago) 111: 592, 1963. CrossrefMedlineGoogle Scholar4. MOORE HC: Recurrent jaundice of pregnancy. Lancet 2: 57, 1963. CrossrefGoogle Scholar5. SVANBORG A: A study of recurrent jaundice in pregnancy. Acta Obstet. Gynee. Scand. 33: 434, 1954. CrossrefMedlineGoogle Scholar6. POPPERSCHAFFNER HF: Drug induced hepatic injury. Ann. Intern. Med. 51: 1230, 1959. LinkGoogle Scholar7. SCHAFFNERKNIFFEN FJC: Electron microscopy as related to hepatotoxicity. Ann. NY Acad. Sci. 104: 847, 1963. CrossrefGoogle Scholar8. HOPPE RC: Personal communication, 1964. Google Scholar9. ADLERCREUTZIKONEN HE: Oral contraceptives and liver damage. Brit. Med. J. 2: 1133, 1964. CrossrefGoogle Scholar10. ADLERCREUTZ H: Steroidbetingad ikterus. Nord. Med. 72: 1004, 1964. MedlineGoogle Scholar11. HSIADOWBENSHAW DYRMR: Inhibition of glucuronosyl transferase by progestational agents from the serum of pregnant women. Nature (London), 187: 693, 1960. CrossrefMedlineGoogle Scholar12. ARIAS IM: Personal communication, 1964. Google Scholar13. MUELLERKAPPAS MNA: Estrogen pharmacology. I. The influence of estradiol and estriol on hepatic disposal of sulfobromophthalein (BSP) in man. J. Clin. Invest. 43: 1905, 1964. CrossrefMedlineGoogle Scholar14. GALLAGHERKAPPAS TFA: Estrogen effects on BSP metabolism in rats. Fed. Proc. 24: 144, 1965. Google Scholar15. SHEEHAN HL: Jaundice in pregnancy. Amer. J. Obstet. Gynec. 81: 427, 1961. CrossrefGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Madison, Wisconsin, and New York, New YorkFrom the Department of Medicine, the University of Wisconsin School of Medicine, Madison, Wisc., and the Department of Pathology, Mount Sinai Hospital, New York, N. Y.Requests for reprints should be addressed to William C. Boake, M.D., Department of Medicine, University Hospitals, 1300 University Ave., Madison, Wisc. 53706 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByHepatobiliary complications of oral contraceptivesEffect of endrin and endrin derivatives on hepatobiliary function and carbon tetrachloride-induced hepatotoxicity in male and female ratsSerum bile acids during biphasic contraceptive treatment with ethinyl estradiol and norgestrelDrug-Induced Liver Reactions: A Morphological ApproachJaundice in pregnancy—1976Various forms of chemically induced liver injury and their detection by diagnostic procedures.Benign cholestatic jaundice of pregnancy and benign cholestatic jaundice from oral contraceptivesSerum protein-bound carbohydrate and seromucoid in pill usersORAL CONTRACEPTION AND LIVER FLUKE DISEASESome aspects of the interaction between natural and synthetic female sex hormones and the liverHormones and the liverThe Influence of Estrogens, Progestins, and Pregnancy on the LiverTHE LIVER TOXICITY OF ORAL CONTRACEPTIVES: A CRITICAL REVIEW OF THE LITERATURELIVER DISEASE IN PREGNANCY, WITH PARTICULAR EMPHASIS ON THE CHOLESTATIC SYNDROMESOvulatory suppressants, estrogens, and carbohydrate metabolismLiver Dysfunction with Mestranol but not with Norethynodrel in a Patient with Enovid®-Induced JaundiceERNEST URBAN, M.B., BARRY W. FRANK, M.D., FRED KERN JR., M.D., F.A.C.P.Liver Function Studies and Progestagen ContraceptionSonstige Wirkungen von GestagenenRecurrent cholestatic jaundice of pregnancy with demonstrated estrogen sensitivityRecurrent jaundice in pregnancyHepatic Effects of Oral ContraceptivesPlasma Lipids in Recurrent Jaundice of PregnancyBiliary Secretory Failure in Man The Problem of CholestasisSHEILA SHERLOCK, M.D., F.R.C.P., F.R.C.P.E., F.A.C.P. (HON.)Effect of norethandrolone, acetohexamide, and enovid on α-naphthylisothiocyanate-induced hyperbilirubinemia and cholestasis 1 August 1965Volume 63, Issue 2Page: 302-308KeywordsBirthHepatitisHospital medicineIngestionLiverNecrosisPregnancyPruritus Issue Published: 1 August 1965 PDF DownloadLoading ...