tbuckley/cabot-search huggingface dataset:
Abstract 4862: Cancer chemopreventive potential of grape seeds and skin in mice inoculated with Ehrlich ascites carcinoma cells.
Authors: Nariman K. Badr El-Din, Doaa A. Ali, Rania F. Abou-El-Magd, Nahed A. Soliman
Journal: Cancer Research (2013)

Abstract Chemoprevention by dietary constituents holds great promise to control cancer. Grape seeds(GSE) and skin (GSK) contain large amounts of phytochemicals such as flavonoids, phenolic acids, and anthocyanidins, which play an important role as chemopreventive and anticancer agents. This study was undertaken to investigate the chemopreventive effects of GSE and GSK efficacies and associated mechanisms on tumor growth in mice. GSE &amp; GSK were separated from the pulp of grape Vitis vinifera, dried and ground to powder. Equal amounts of GSE &amp; GSK were mixed uniformly with the standard diet powder at concentrations of 10% (w/w). The supplemented diet was started two weeks before tumor cells inoculation and continued until the end of the experiment. Female Swiss albino mice were inoculated subcutaneously with 2.5x106 Ehrlich ascites carcinoma (EAC) cells. Tumor growth was monitored for 30 days.Cell cycle progression was measured and the apoptotic effect of GSE and GSK on tumor cells were evaluated by flow cytometric analysis, histopathology and transmission electron microscopy examination. GSE &amp; GSK intake prevented tumor development in 47% of the animals. Tumor volume and tumor weight measured at the termination of the experiment were reduced by 93.9 %&amp; 86.3 %, p&amp;lt; 0.001) respectively as compared to the untreated tumor- bearing mice. GSE&amp; GSK induced a marked increase in the percentage of apoptotic tumor cells as determined by flow cytometric analysis and confirmed by histopathological and electron microscopy examination. These changes were associated with significant G1-phase cell cycle arrest, decrease in the expression of Bcl-2, increase of the expression of p53 and induced caspase-3 activation in the tumor cells. Our data demonstrated that grape seeds&amp; skin intake resulted in profound cell growth inhibition by a mechanism involved G1-phase cell cycle arrest, and apoptosis. Therefore, dietary grape seeds and grape skin possess cancer chemopreventive potential and provide support for their use in human cancer chemoprevention. Citation Format: Nariman K. Badr El-Din, Doaa A. Ali, Rania F. Abou-El-Magd, Nahed A. Soliman. Cancer chemopreventive potential of grape seeds and skin in mice inoculated with Ehrlich ascites carcinoma cells. [abstract]. In: Proceedings of the 104th Annual Meeting of the American Association for Cancer Research; 2013 Apr 6-10; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2013;73(8 Suppl):Abstract nr 4862. doi:10.1158/1538-7445.AM2013-4862
DETECTION OF LEFT ATRIAL AND LEFT ATRIAL APPENDAGE FUNCTIONAL RECOVERY FOLLOWING CARDIOVERSION IN PATIENTS WITH ATRIAL FIBRILLATION: SERIAL ECHOCARDIOGRAPHIC STUDY
Authors: Ahmed S. Ammar, Ebtesam I. El-Dosoky, Islam Elsherbiny, Khaled M. Abd Elsalam, Mohammed A. Abd El-Hamid
Journal: Journal of the American College of Cardiology (2014)
Clq metabolism in ulcerative colitis and Crohn's disease.
Authors: B J Potter, H J Hodgson, A S Mee, D P Jewell
Journal: Gut (1979)

The metabolism of pure radioiodine labelled Clq has been observed in five patients with ulcerative colitis, five patients with Crohn's disease, and in five control subjects. Both the fractional catabolic rate and the synthesis rate of Clq were increased in the five patients with Crohn's disease and in four of the five patients with ulcerative colitis. The fifth patient was in remission and had a normal synthesis rate. These results support the hypothesis that complement activation plays a role in the pathogenesis of these disease states and that the increased complement activation is primarily via the classical pathway.
Differential effects of proteasome inhibition by bortezomib on murine acute graft-versus-host disease (GVHD): delayed administration of bortezomib results in increased GVHD-dependent gastrointestinal toxicity
Authors: Kai Sun, Danice E. C. Wilkins, Miriam R. Anver, Thomas J. Sayers, Angela Panoskaltsis-Mortari, Bruce R. Blazar, Lisbeth A. Welniak, William J. Murphy
Journal: Blood (2005)
Psychological Predictors of Glycemic Change with Relaxation Training in Non-Insulin-Dependent Diabetes mellitus
Authors: James E. Aikens, Theresa A. Kiolbasa, Robert Sobel
Journal: Psychotherapy and Psychosomatics (1997)

Background: Previous findings are unclear regarding the possible glycemic benefits of applying behavioral relaxation training in non-insulin-dependent diabetes mellitus (NIDDM). Methods: Subjects with NIDDM were randomized to relaxation training (6 sessions of progressive muscle relaxation and imagery, n = 12) or control treatment (routine medical care, n = 10). Physiological measures were total glycosylated hemoglobin (GHb) and area under the 2-hour oral-glucose-tolerance curve (AUC). Psychological measures of generalized distress, anxiety and daily stress were also administered. All subjects were assessed before and after the 8-week intervention, and again at 16 weeks of long-term follow-up. Results: There were no postintervention group differences in physiological variables. Highly distressed subjects and those who rated their glucose as more stress responsive tended to practice relaxation less between sessions. Within the treated group only, lower preintervention stress responsivity was associated with greater improvement in GHb, and lower anxiety and distress levels predicted long-term improvement in AUC. Conclusions: It remains unclear whether relaxation training produces glycemic benefits in NIDDM. Perhaps the least anxious and stress-responsive patients only benefit from group-based relaxation training, whereas anxious individuals require intensive individually administered interventions.
Norman Lockner Lecture on MEDICAL RESEARCH: THE TREE AND THE FRUIT
Authors: W. M. Fletcher
Journal: BMJ (1929)

Iii fielil (if o l; I 'a,.ki votI to coilsi(ler1 to-day is tilit 1toov bioo dly be called miedicil: it is the age-10log stuidty hv manl of thle oovstei-ie-(if 1lii' (oW l tbody ai(d of its fiulctioll.c.if We thilink of the htistory of the llmatheiilatical,
Lipomatous mixed tumour of the skin: a histological, immunohistochemical and ultrastructural study
Authors: C. Miracco, M.M. De Santi, A.V. Lalinga, M. Pellegrino, K. SchUrfeld, P. Sbano, F. Miracco
Journal: British Journal of Dermatology (2002)

Journal Article Lipomatous mixed tumour of the skin: a histological, immunohistochemical and ultrastructural study Get access C. Miracco, C. Miracco Institute of Pathological Anatomy and Histology, Policlinico Le Scotte, University of Siena, Viale Bracci 6, 53100 Siena, Italy Clelia Miracco. E‐mail: miracco@unisi.it Search for other works by this author on: Oxford Academic Google Scholar M.M. De Santi, M.M. De Santi Institute of Pathological Anatomy and Histology, Policlinico Le Scotte, University of Siena, Viale Bracci 6, 53100 Siena, Italy Search for other works by this author on: Oxford Academic Google Scholar A.V. Lalinga, A.V. Lalinga Institute of Pathological Anatomy and Histology, Policlinico Le Scotte, University of Siena, Viale Bracci 6, 53100 Siena, Italy Search for other works by this author on: Oxford Academic Google Scholar M. Pellegrino, M. Pellegrino Institute of Dermatological Science, University of Siena, Italy Search for other works by this author on: Oxford Academic Google Scholar K. SchÜrfeld, K. SchÜrfeld Institute of Pathological Anatomy and Histology, Policlinico Le Scotte, University of Siena, Viale Bracci 6, 53100 Siena, Italy Search for other works by this author on: Oxford Academic Google Scholar P. Sbano, P. Sbano Institute of Dermatological Science, University of Siena, Italy Search for other works by this author on: Oxford Academic Google Scholar F. Miracco F. Miracco Department of Ophthalmological Science, University of Siena, Italy Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 146, Issue 5, 1 May 2002, Pages 899–903, https://doi.org/10.1046/j.1365-2133.2002.04645.x Published: 01 May 2002 Article history Accepted: 25 October 2001 Published: 01 May 2002
Hemochromatosis and Hemosiderosis
Authors: Wade Volwiler
Journal: JAMA (1964)

This book presents a well-organized, exhaustive review of the world's literature on these subjects, and an interesting account of the author's own researches and personal bias. Skeptical of the traditional belief that hemochromatosis results from an inborn error of metabolism associated with an abnormal increase in intestinal absorption of iron. he believes that hemochromatosis actually consists of two unrelated conditions, an ordinary cirrhosis (usually nutritional or alcoholic) and "benign" excess of body iron deposited in cells of characteristic tissues. Additionally, he states that the excess body iron in diopathic hemochromatosis comes primarily from an excessive ingestion of iron, normally absorbed, instead of excessive absorption of a normal dietary intake of iron. It is carefully pointed out that the pathological counterpart of clinical hemochromatosis has never been produced experimentally in laboratory animals by means of iron overload. The author has been able to produce in the livers of animals histopathological states
Remission of Maternal Depression and Children’s Psychopathology—Reply
Authors: Myrna M. Weissman, Jonathan E. Alpert, Maurizio Fava, Madhukar H. Trivedi, A. John Rush
Journal: JAMA (2006)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Short term outcome in babies refused perinatal intensive care.
Authors: H. Sidhu, R. N. Heasley, C. C. Patterson, H. L. Halliday, W. Thompson
Journal: BMJ (1989)

To compare the mortality in babies refused admission to a regional perinatal centre with that in babies accepted for intensive care in the centre.Retrospective study with group comparison.Based at the Royal Maternity Hospital, Belfast, with follow up of patients in all obstetric units in Northern Ireland.Requests for transfer of 675 babies to the regional perinatal centre (prenatally and postnatally) were made from hospitals in Northern Ireland between January 1984 and December 1986. In all, 343 babies were refused admission to the centre, and complete data were available for 332 of them. These babies were either admitted to other neonatal intensive care units (261 babies) or remained in hospitals with only special care cots (71 babies).Short term mortality.Seventy of the 332 babies refused admission to the centre died compared with 51 of the 333 who were admitted. Multivariate analysis based on a logistic model showed a non-significant increase in mortality among babies treated in other intensive care units compared with babies treated in the centre (relative odds 1.2; 95% confidence interval 0.7 to 1.9). The increase in mortality in babies who remained in a special care baby unit, however, was significant (3.5; 1.7 to 7.0). This increase was particularly significant in babies born at less than or equal to 32 weeks' gestation and who weighed less than 1500 g (8.4; 2.5 to 28.1).The results of the study confirm the benefits of neonatal intensive care and its particular value in improving survival in babies of low birth weight. As the babies were refused admission to the regional perinatal centre because intensive care cots were not available this deficiency should be corrected.The study reported sought to compare the mortality in infants refused admission to Northern Ireland's regional perinatal center with that in babies accepted by the center. Admission was determined by bed availability. Over a three-year period, 343 of 675 prenatal or postnatal transfer requests were refused. Complete data available for 332 of the refusals showed that 261 infants were cared for in neonatal intensive care units (NICUs) in other hospitals, and 71 infants were cared for in special care units in other hospitals. There was no significant increase in mortality for infants treated in other NICUs, while the infants treated in special care units had a greater than threefold chance of dying. Long-term outcome for both groups remains uncertain. The authors call for more neonatal intensive care beds and further study of the effects of delaying or denying intensive care for at-risk infants.
Erythrocytosis induced by danazol in an anephric patient.
Authors: I K Barton, M A Mansell
Journal: BMJ (1987)

Erythrocytosis induced by danazol in an anephric patient An anephric patient undergoing continuous ambulatory peritoneal dialysis developed erythrocytosis after treatment of menorrhagia with danazol; this was associated with a high serum immunoreactive erythropoietin concentra- tion, presumably ofhepatic origin.This may suggest a use for danazol in the treatment of refractory anaemias.
A Controlled Clinical Evaluation of Antiemetic Drugs
Authors: Charles G. Moertel
Journal: JAMA (1963)

A controlled double-blind study of five orally administered antiemetic agents and a placebo was carried out during the administration to patients of a known emetic agent, fluorouracil. One hundred eighty patients were observed during their first course of treatment with fluorouracil and 120 patients during their second course. Thiopropazate and prochlorperazine showed a statistically significant therapeutic advantage over the placebo. Pipamazine, cinnarizine, and trimethobenzamide were progressively less effective, although each appeared to exert some antiemetic effect. Those agents showing the greatest antiemetic potency also showed the highest incidence of oversedation.
Modern obstetrics and the general practitioner.
Authors: E Wilkes, R A Dixon, J Knowelden
Journal: BMJ (1975)

In a changing obstetric world we thought it timely to survey the work and attitudes of general practitioners with special obstetric training. Such a survey might have useful service and educa tional implications. We decided therefore to send a question naire to holders of the DObstRCOG qualification old enough to have settled into their practices but not so senior that they had begun to restrict their obstetric responsibilities. We were interested also to obtain some secondary information on gynaecology, family planning, and abortion from the viewpoint of the general-practitioner obstetrician.
Abstract 176: The presence of RNA polymerase II, active or stalled, predicts epigenetic fate of promoter CpG islands
Authors: Hideyuki Takeshima, Satoshi Yamashita, Taichi Shimazu, Tohru Niwa, Toshikazu Ushijima
Journal: Cancer Research (2010)

Abstract Aberrant DNA methylation of promoter CpG islands (CGIs) is deeply involved in cancers and other disorders. Contrary to our initial expectations, aberrant methylation is now recognized to possess several unique characteristics different from mutations [Ushijima and Asada, Cancer Sci, 2010]. One of the remarkable differences is target gene specificity. Specific cancers have aberrant methylation of specific genes, and specific inducers of methylation, such as Helicobacter pylori infection, induce methylation of specific genes [Nakajima et al, Int J Cancer, 2009]. As the mechanism of target gene specificity (namely, instructive mechanism), low transcription levels and trimethylation of histone H3 lysine27 (H3K27me3) in precursor cells are known to promote methylation induction. However, factors that protect genes from aberrant methylation are unknown. To identify protective factors, we first isolated 5,510 and 521 genes resistant and susceptible, respectively, to aberrant methylation induction by methylated DNA immunoprecipitation (MeDIP)-on-chip analysis of nucleosome-free regions of promoter CGIs in normal prostatic epithelial cells and four prostate cancer cell lines. Then, by gene expression analysis, the susceptible genes were shown to have low transcription levels in normal prostatic epithelial cells. Finally, by ChIP-on-chip analysis in normal prostatic epithelial cells, we revealed that, even among the genes with low transcription, genes with high active histone modifications and binding of RNA polymerase II (Pol II) had marked resistance to aberrant methylation induction, and confirmed that genes with high H3K27me3 had marked susceptibility to aberrant methylation induction. On the other hand, another repressive histone modification, trimethylation of histone H3 lysine9 (H3K9me3), was not associated with resistance or susceptibility. By multivariate analysis, Pol II binding showed stronger influence on the resistance than active histone modifications, and H3K27me3 showed independent influence on the susceptibility. The same was true in normal mammary epithelial cells for 5,430 and 733 genes resistant and susceptible, respectively, to aberrant methylation in breast cancers [Takeshima et al, Genome Res, 2009]. These results indicated that the presence of Pol II, active or stalled, protects promoter CGIs from aberrant DNA methylation, independently of transcription levels. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 101st Annual Meeting of the American Association for Cancer Research; 2010 Apr 17-21; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2010;70(8 Suppl):Abstract nr 176.
Antibodies to toluene diisocyanate in an environmentally exposed population.
Authors: K G Orloff, D Batts-Osborne, T Kilgus, S Metcalf, M Cooper
Journal: Environmental Health Perspectives (1998)

Residents living near a polyurethane foam manufacturing facility expressed concern to health officials over chemical emissions from the plant. Environmental monitoring of ambient air near the plant indicated the presence of toluene diisocyanate (TDI), which was used in foam production. Health officials collected blood samples from 113 residents and analyzed the blood sera for antibodies to TDI and related diisocyanates. Ten of the 113 residents (9%) had elevated levels of IgG or IgE antibodies specific for one or more diisocyanates. Exposure histories were taken from antibody-positive individuals to identify possible occupational exposure to TDI or the use of diisocyanate-containing consumer products. Exposure to TDI in ambient air may be responsible for the positive antibody responses detected in some residents of the community.
Comparable survival between HIV+ and HIV− non-Hodgkin and Hodgkin lymphoma patients undergoing autologous peripheral blood stem cell transplantation
Authors: José L. Díez-Martín, Pascual Balsalobre, Alessandro Re, Mariagrazia Michieli, José M. Ribera, Carmen Canals, Eulogio Conde, Anne Rosselet, Ian Gabriel, Rosario Varela, Bernardino Allione, Kate Cwynarski, Philippe Genet, Ildefonso Espigado, Pierre Biron, Norbert Schmitz, Anne E. Hunter, Augustin Ferrant, Gaelle Guillerm, Mark Hentrich, Manuel Jurado, Pascual Fernández, David Serrano, Giuseppe Rossi, Anna Sureda
Journal: Blood (2009)
Two men plead with judges to let doctors end their life legally
Authors: C. Dyer
Journal: BMJ (2012)

A man paralysed from the neck down made legal history on Tuesday 19 June when he asked three senior judges at the High Court in London to rule that doctors should be allowed to kill him legally.

Tony Nicklinson, who has locked-in syndrome after a catastrophic stroke in 2005, is seeking a declaration that a doctor who ended his life at his request could invoke the defence of necessity, legalising what would otherwise be murder.1

Nicklinson, 58, is too disabled for an assisted suicide and would not be able to lift a cup with a lethal dose of phenobarbital to his lips, his barrister, Paul Bowen QC, told …
Increased angiogenesis in portal hypertensive rats: Role of nitric oxide
Authors: Lazar T. Sumanovski, Edouard Battegay, Michael Stumm, Maaike van der Kooij, Cornel C. Sieber
Journal: Hepatology (1999)

Systemic and especially splanchnic arterial vasodilation accompany chronic portal hypertension. Different soluble mediators causing this vasodilation have been proposed, the strongest evidence being for nitric oxide (NO). No data exist if structural vascular changes may partly account for this vasodilatory state. Here, we developed a new in vivo quantitative angiogenesis assay in the abdominal cavity and determined if: 1) portal hypertensive rats show increased angiogenesis; and 2) angiogenesis is altered by inhibiting NO formation. Portal hypertension was induced by partial portal vein ligation (PVL). Sham–operated rats served as controls (CON). During the index operation (day 0), a teflon ring filled with collagen I (Vitrogen 100) was sutured in the mesenteric cavity. After 16 days, rings were explanted, embedded in paraffin, and ingrown vessels counted using a morphometry system. The role of NO was tested by adding an antagonist of NO formation ( N ω –nitro– l –arginine [NNA], 3.3 mg/kg/d) into the drinking water. The mean number of ingrown vessels per implant was significantly higher in PVL rats compared with CON rats, i.e. , 1,453 ± 187 versus 888 ± 116, respectively ( P &lt; .05; N = 5 per group). NNA significantly ( P &lt; .01) inhibited angiogenesis in PVL (202 ± 124; N = 5) and in CON (174 ± 25; N = 6) rats, respectively. In contrast, the β–adrenergic blocker, propranolol, did not prevent angiogenesis either in PVL or CON rats in a separate set of experiments (data not shown). The conclusions drawn from this study are that: 1) rats with portal hypertension show increased angiogenesis; and 2) inhibition of NO formation significantly prevents angiogenesis in both PVL and CON rats. Therefore, splanchnic vasodilation in chronic portal hypertension may also be a result of structural changes. (Hepatology 1999;29:1044–1049.)
Membership in the American Medical Association and the New York Profession.
Authors: Frank Billings
Journal: JAMA (1903)

Chicago, Jan. 23, 1903. <h3>To the Editor:</h3> —I send herewith, for publication inThe Journal, a copy of my reply to a letter received from a New York physician. It explains itself. I have purposely gone into details with the intention of publishing the matter. I have done so for the reason that I feel that there is a misunderstanding on the part of some of the members of the profession, especially in New York, as to the position held by the American Medical Association in regard to the conditions in that state. Very truly yours,