tbuckley/cabot-search huggingface dataset:
Abstract 15576: Implementation of a Knowledge Translation and Education Tool to Improve Appropriate Use of Stress Echocardiography at a Large Academic Medical Center in a Public Funded Healthcare System
Authors: Kevin Levitt, Chi-ming Chow, Jeremy Edwards, Sacha Bhatia
Journal: Circulation (2014)

Introduction: Previous retrospective studies have suggested that Appropriate Use of Stress Echocardiograms (SE) is sub-optimal, but there have not been effective interventions developed to improve appropriate use of SE. Methods: We conducted a prospective, pre (Jul 1 - Oct 15 2013) and post (Mar 1-May 31 2014) time series analysis of an educational intervention that included the development and implementation of a new ordering requisition that integrated Appropriate Use Criteria (AUC) for SE within it. Results: During the control period, 221 consecutive were evaluated using the 2011 AUC and 98% were classifiable. Overall the inappropriate rate of classifiable studies was 32%, while the appropriate rate was 64% and uncertain rate 4%. During the intervention period, 156 studies were evaluated and 98% were classifiable. Implementation of the KT tool and educational intervention resulted in an increase in the appropriateness rate to 76% (p=0.016) and a reduction in the inappropriate rate to 19% (p=0.003) of a...
Familiar Letters on Chemistry, and its relation to Commerce, Physiology, and Agriculture
Authors: Justus von Liebig
Journal: BMJ (1843)

These letters, as we learn from the author's preface, were intended to be mere sketches of some of the most important subjects on which chemistry comes into immediate relation with human welfare; and were written for the especial purpose of exciting the attention of governments and an enlightened public, to the necessity of establishing schools of chemistry, and of promoting, by every means, the study of a science so intimately connected with the arts
How to write an abstract that will be accepted
Authors: Mary Higgins, Maeve Eogan, Keelin O’Donoghue, Noirin Russell
Journal: BMJ (2013)

Researchers do not always appreciate the importance of producing a good abstract or understand the best way of writing one. <b>Mary Higgins and colleagues</b> share some of the lessons they have learnt as both researchers and reviewers of abstracts
Correlation of In Vivo Malignancy With In Vitro Properties of Human-Mouse Hybrid Cells 2
Authors: Mary R. Bordelon, Thomas B. Shows, T. R. Chen, Elton Stubblefield
Journal: JNCI Journal of the National Cancer Institute (1976)

The in vivo tumorigenicity of malignant mousenonmalignant human somatic cell hybrids was correlated with the in vitro characteristics. The renal adenocarcinoma mouse cell line RAG and the normal, diploid human cell line WI-38 were used as the fusion parents. Five independent RAG-WI-38 hybrid clones were tested for concanavalin A (Con A) agglutination patterns, in vitro invasiveness, and tumor formation in immunosuppressed mice. Tests on the parental lines showed that RAG cells agglutinated at much lower levels of Con A than the WI-38 cells. RAG cells overgrew WI-38 cells in the in vitro invasiveness assay. RAG cells readily formed tumors in untreated adult or young immunosuppressed mice, whereas the WI-38 cells did not. The five hybrid clones were all similar. since they had Con A agglutination levels intermediate to those of both parents, though patterns were more “tumor-like”, overgrew the WI-38 cells in the invasiveness assay, and formed tumors in immunosuppressed mice.
Cholinergic induction of perspiration attenuates nonhistaminergic pruritus in the skin of patients with atopic dermatitis and healthy controls
Authors: L.A. Nattkemper, H.G. Lee, R. Valdes-Rodriguez, N.K. Mollanazar, K.M. Sanders, G. Yosipovitch
Journal: British Journal of Dermatology (2014)

Journal Article Cholinergic induction of perspiration attenuates nonhistaminergic pruritus in the skin of patients with atopic dermatitis and healthy controls Get access L.A. Nattkemper, L.A. Nattkemper Department of Dermatology Temple University School of Medicine Philadelphia PA U.S.ATemple Itch Center Temple University School of Medicine Philadelphia PA U.S.A Search for other works by this author on: Oxford Academic Google Scholar H.G. Lee, H.G. Lee Department of Dermatology Temple University School of Medicine Philadelphia PA U.S.ATemple Itch Center Temple University School of Medicine Philadelphia PA U.S.A Search for other works by this author on: Oxford Academic Google Scholar R. Valdes‐Rodriguez, R. Valdes‐Rodriguez Department of Dermatology Temple University School of Medicine Philadelphia PA U.S.ATemple Itch Center Temple University School of Medicine Philadelphia PA U.S.A Search for other works by this author on: Oxford Academic Google Scholar N.K. Mollanazar, N.K. Mollanazar Department of Dermatology Temple University School of Medicine Philadelphia PA U.S.ATemple Itch Center Temple University School of Medicine Philadelphia PA U.S.A Search for other works by this author on: Oxford Academic Google Scholar K.M. Sanders, K.M. Sanders Department of Dermatology Temple University School of Medicine Philadelphia PA U.S.ATemple Itch Center Temple University School of Medicine Philadelphia PA U.S.A Search for other works by this author on: Oxford Academic Google Scholar G. Yosipovitch G. Yosipovitch Department of Dermatology Temple University School of Medicine Philadelphia PA U.S.ATemple Itch Center Temple University School of Medicine Philadelphia PA U.S.A Correspondence: Gil Yosipovitch. E‐mail: gil.yosipovitch@tuhs.temple.edu Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 173, Issue 1, 1 July 2015, Pages 282–284, https://doi.org/10.1111/bjd.13629 Published: 01 July 2015
Immune Status in a Primary Smallpox Vaccinee Who Failed to Develop an Immunization Site Reaction
Authors: John M Kelso, Kevin M Kuhn, Frances K Newman, Jeffrey S Kennedy, Sharon E Frey
Journal: JAMA (2005)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Abstract 19735: Temporal Trends in Sample Size of RCTs in Published Cardiology Literature from 1970-2013
Authors: Sonia Jain, Sushil A Luis, Vivien Coelho, Limor Ilan Bushari, Hilma Holm, Arun Subramanian
Journal: Circulation (2014)

Background: It is generally perceived that sample sizes of randomized clinical trials (RCTs) have increased over the years, particularly in specialties such as cardiology, with a robust evidence base. The aim of this study was to analyze temporal trends in sample sizes of RCTs in cardiology journals compared to other specialties. Methods: Abstracts of RCTs involving humans from PubMed for 1970-2013 were analyzed using a digital search algorithm. Sample sizes of studies were extracted from each abstract. Date of publication and journal name were collected. Journals from several medical subspecialties were selected for comparison, using the journal impact factor as a measure of clinical relevance. Sample sizes of studies in 1990 were compared to 2010 for each of the journals using the Mann-Whitney U test. Graphical comparisons of sample size trends are presented. Results: 272,054 abstracts of human RCTs were identified. Median sample sizes for the years 1990 and 2010 is shown in table 1. The median sample size for all RCTs published in Circulation was 99 subjects per study in 1990, increasing to 630 subjects per study in 2010 (p &lt; 0.01). All cardiology journals had a significant increase in study sample size over the 20 year period, as did the multispecialty journals (JAMA, NEJM, Lancet). In contrast, only a few non-cardiology specialty journals published studies with increasing sample sizes (table 1). Figure 1 shows the sample size trend for 1970-2013. Conclusions: Our study demonstrates a dramatic temporal trend of increasing sample sizes in RCTs in cardiology compared to other specialties. Since sample size is estimated based on the effect size studied, one explanation for this observation is that the more obvious larger effects have been previously elucidated, leaving only smaller associations to be studied. This requires increasing resources, highlighting the importance of alternate study designs and collaborative registries to develop a cost effective evidence base.
Secret book deal to counter Canadian drugs exposed
Authors: Jeanne Lenzer
Journal: BMJ (2005)

A secret scheme to scare the US public into opposing legislation that would allow the importation of Canadian drugs—drugs that compete with expensive US drugs—has been uncovered after a book deal went sour.

The fictional book about terrorists, a bit of sex, and poisoned Canadian pills was commissioned as part of an effort to cause US citizens to worry about the safety of Canadian drugs. The US ban on importing Canadian drugs combined with the exorbitant prices of US drugs means that many patients resort to internet purchases from Canada and elsewhere.

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The scheme came to light after an argument between the book's writers and its backers when …

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Increased Oxidative Stress in Patients With Congestive Heart Failure 11This study was supported by a grant jointly sponsored by the Medical Research Council of Canada, Ottawa and Bayer Pharmaceuticals, Etobicoke, Ontario, Canada.
Authors: Mary Keith, Amir Geranmayegan, Michael J Sole, Regina Kurian, Andrew Robinson, Ahmad S Omran, Khursheed N Jeejeebhoy
Journal: Journal of the American College of Cardiology (1998)
Reply to Gianluca Giannarini, Nazareno Suardi and Alberto Briganti's Letter to the Editor re: Prasanna Sooriakumaran, Abhishek Srivastava, Shahrokh F. Shariat, et al. A Multinational, Multi-institutional Study Comparing Positive Surgical Margin Rates Among 22 393 Open, Laparoscopic, and Robot-assisted Radical Prostatectomy Patients. Eur Urol. In press. http://dx.doi.org/10.1016/j.eururo.2013.11.018
Authors: Prasanna Sooriakumaran, Peter Wiklund, Monique J Roobol, Ewout Steyerberg, Rafael Sanchez-Salas, Xavier Cathelineau, Ashutosh K Tewari
Journal: European Urology (2014)
ALVEOLAR-CAPILLARY DIFFUSION DEFECT: A CASE REPORT
Authors: P WINCHELL
Journal: Annals of Internal Medicine (1956)

Case Reports1 November 1956ALVEOLAR-CAPILLARY DIFFUSION DEFECT: A CASE REPORTPAUL WINCHELL, M.D.PAUL WINCHELL, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-45-5-957 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptA group of chronic pulmonary diseases showing diffuse thickening of the alveolar septa has been shown to result in impairment of alveolar-capillary diffusion.1The usual example of the syndrome presents with dyspnea, cyanosis, polycythemia and signs of chronic cor pulmonale, yet the partial pressure of carbon dioxide in the arterial blood is normal or low despite serious oxygen desaturation. Various causes for the chronic pulmonary disease responsible for this situation have been noted, including scleroderma, berylliosis, sarcoidosis and silicosis, but most of the cases seem to be cryptogenic pulmonary fibrosis. Reports concerning the effectiveness of adrenocorticotropic hormone in this group...Bibliography1. AustrianClementRenzettiDonaldRileyCournand RJHADKWRLA: Clinical and physiologic features of some types of pulmonary diseases with impairment of alveolar-capillary diffusion, Am. J. Med. 11: 667, 1951. CrossrefMedlineGoogle Scholar2. KennedyParePumpBeckJohnsonEpsteinVenningBrowne BJJAKKJCLGNBEHJS: Effect of adrenocorticotrophic hormone (ACTH) on beryllium granulomatosis and silicosis, Am. J. Med. 10: 134, 1951. CrossrefMedlineGoogle Scholar3. WestMcClementCarrollBlissKuschnerRichardsCournand JRJHDHAMDWA: Effects of cortisone and ACTH in cases of chronic pulmonary disease with impairment of alveolar-capillary diffusion, Am. J. Med. 10: 156, 1951. CrossrefMedlineGoogle Scholar4. Robinson S: Experimental studies of physical fitness in relation to age, Arbeits physiol. 10: 251, 1938. Google Scholar5. Altschule MD: Physiology in diseases of the heart and lungs, 1949, Harvard University Press, Cambridge, Mass., p. 76. Google Scholar6. Riley RL: Pulmonary gas exchange, Am. J. Med. 10: 210, 1951. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Minneapolis, Minnesota*Received for publication June 29, 1955.From the Department of Medicine, University of Minnesota Medical School and Hospitals (Variety Club Heart Hospital).Requests for reprints should be addressed to Paul Winchell, M.D., Department of Medicine, University of Minnesota Hospitals, Minneapolis 14, Minnesota. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byDIFFUSE INTERSTITIAL PULMONARY FIBROSIS AND HONEYCOMB LUNG 1 November 1956Volume 45, Issue 5Page: 957-962KeywordsDyspneaFibrosisHospital medicinePartial pressure of carbon dioxidePulmonary diseasesPulmonary fibrosisSarcoidosisSclerodermaSilicosisThorax ePublished: 1 December 2008 Issue Published: 1 November 1956 PDF downloadLoading ...
Abstract 809: EQ-5D Utility Index in Atrial Fibrillation: Insights From a Large Multinational Registry of Atrial Fibrillation (Record-AF)
Authors: Paul Dorian, Caroline Amand
Journal: Circulation (2009)

Introduction: Atrial Fibrillation (AF) impairs Health Related Quality of life (HRQoL). No large studies of AF patients have used tools validated for utility index which can be used to compare HRQoL...
Brief Report: Erosions and Sclerosis on Radiographs Precede the Subsequent Development of Syndesmophytes at the Same Site: A Twelve‐Year Prospective Followup of Patients With Ankylosing Spondylitis
Authors: Sofia Ramiro, Astrid van Tubergen, Désirée van der Heijde, Carmen Stolwijk, Gideon Bookelman, Maxime Dougados, Filip van den Bosch, Robert B. M. Landewé
Journal: Arthritis & Rheumatology (2014)

To analyze whether erosions, sclerosis, and squaring assessed on radiographs precede the development of syndesmophytes in patients with ankylosing spondylitis (AS).Patients with AS from the Outcome in Ankylosing Spondylitis International Study (OASIS) cohort were followed up for 12 years, with radiographs obtained every 2 years. Two readers (reader 1 and reader 2) scored radiographs according to the modified Stoke Ankylosing Spondylitis Spine Score (mSASSS) and recorded abnormalities per vertebral corner. Progression from erosions, sclerosis, or squaring to (bridging) syndesmophytes was investigated using multilevel longitudinal (autoregressive and time-lagged) regression analysis. Interactions with reader and spinal region were investigated.The analysis included 211 patients (71% male, 85% HLA-B27 positive) with a mean ± SD age of 43 ± 13 years and a symptom duration of 21 ± 12 years. A total of 921 radiographs were included, with 20,509 (reader 1) and 20,568 (reader 2) vertebral corners evaluable. Erosions were found in 1% and 2.5%, sclerosis in 0.3% and 1.7%, squaring in 6.5% and 5.1%, and syndesmophytes in 25% and 27%, by reader 1 and reader 2, respectively. The odds ratio for a new syndesmophyte to occur within 2 years at the same vertebral corner if erosions, sclerosis, or squaring were present was 2.0 (95% confidence interval [95% CI] 1.7-2.3) for the cervical and lumbar spine together, 3.1 (95% CI 2.5-3.9) for the cervical spine, and 1.3 (95% CI 1.0-1.6) for the lumbar spine. When vertebral corners with erosions, sclerosis, and squaring were analyzed separately, this effect was statistically significant for erosions and for sclerosis, but not for squaring.Erosions and sclerosis occur infrequently in patients with AS, but when they do occur, they precede the development of a new syndesmophyte, and are therefore important to assess.
Simvastatin, an Inhibitor of Cholesterol Biosynthesis, Shows a Synergistic Effect with N,N′-Bis(2-chloroethyl)-N-nitrosourea and β-Interferon on Human Glioma Cells
Authors: Maurizio R. Soma, Pietro Pagliarini, Giorgio Butti, Rodolfo Paoletti, Pietro Paoletti, Remo Fumagalli
Journal: Cancer Research (1992)

Abstract  The effect of simvastatin, an inhibitor of 3-hydroxy-3-methylglutaryl coenzyme A reductase, on human glioma cell growth was investigated. When incubated with simvastatin, cell proliferation decreased in a concentration-dependent fashion, as measured by cell number and [3H]-thymidine incorporation into DNA (concentration producing 50% inhibition, 60 nm). The effect was detectable 12 h after cells were exposed to the drug and persisted for 2 days. Addition of mevalonate to cells exposed to simvastatin completely restored the parameters evaluated, indicating that the drug specifically inhibited mevalonate synthesis. The effect of simvastatin in combination with β-interferon and N,N′-bis(2-chloroethyl)-N-nitrosourea, both antitumoral drugs, was also evaluated by cell growth inhibition assay. The concentration producing 50% inhibition for each of these drugs was 650 units/ml and 50 nm, respectively. Subliminal concentrations of β-interferon or N,N′-bis(2-chloroethyl)-N-nitrosourea were incubated together with 1 nm simvastatin. The data were analyzed with the aid of an isobologram using the concept of an envelope of additivity. Simultaneous cell exposure to simvastatin with either N,N′-bis(2-chloroethyl)-N-nitrosourea or β-interferon produced a strong synergistic inhibitory effect on cell proliferation. These data provide in vitro support for the possibility that 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors, utilized as plasma cholesterol-lowering agents, could potentiate the effect of antiblastic drugs on tumor growth.
RESEARCH PROBLEMS IN CORONARY HEART DISEASE
Authors: P D WHITE, C FERRERO
Journal: Annals of Internal Medicine (1949)

Article1 July 1949RESEARCH PROBLEMS IN CORONARY HEART DISEASEPAUL D. WHITE, M.D., F.A.C.P., CONSTANTIN FERREROPAUL D. WHITE, M.D., F.A.C.P.Search for more papers by this author, CONSTANTIN FERREROSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-31-1-33 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptResearches in coronary heart disease until very recently have been largely in the fields of statistical incidence, pathology, diagnosis, prognosis, and empiric therapy. Now and then there have been in the past flashes of interest in the etiology and pathogenesis stimulated on occasion by observations and questioning of a few far-sighted persons like Timothy Leary of Boston, but in general an attitude of fatalism, indifference, or hopelessness has held in check the curiosity of the medical world. "It is God's will" has been more or less the unspoken attitude of both laymen and doctors ever since the first description of... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: *Presented at the Thirtieth Annual Session of the American College of Physicians, New York, N. Y., March 29, 1949. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByCoronary disease and modern stress*The Functioning of the Political Community in TimorDIET AND CORONARY DISEASERECENT HISTORY OF CORONARY DISEASECORONARY DISEASE AND MODERN STRESS 1 July 1949Volume 31, Issue 1Page: 33-38KeywordsCoronary heart diseaseEtiologyPathogenesis Issue Published: 1 July 1949 PDF DownloadLoading ...
Clinical Trial Registry
Authors: Mike Mitka
Journal: JAMA (2005)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Bloodstream infections in a medical–surgical intensive care unit: incidence, aetiology, antimicrobial resistance patterns of Gram-positive and Gram-negative bacteria
Authors: I. Erdem, A. Ozgultekin, A. Sengoz Inan, D. Ozturk Engin, S. Senbayrak Akcay, G. Turan, E. Dincer, N. Oguzoglu, P. Goktas
Journal: Clinical Microbiology and Infection (2009)
Therapy With Antibody-Coated Immune and Hyperimmune Peritoneal Cells in a Murine Lymphoma System2
Authors: H. F. J. Dullens, R. A. De Weger, R. A. Woutersen, W. Den Otter
Journal: JNCI Journal of the National Cancer Institute (1975)

Goat-antimouse (DBA/2) SL2 lymphoma immunoglobulin was specifically cytotoxic to DBA/2-derived sl2 lymphoma cells. This anti-SL2 immunoglobulin, or a part of it, was cytophylic for peritoneal macrophages as shown by target cells adhering to macrophages incubated in vitro with the immunoglobulin. The target cells became free in the medium after incubation with 0.1% trypsin for 1 hour. In in vivo experiments, the incubation of immune or hyperimmune peritoneal cells with immunoglobulin from normal goat serum or from goat-anti-SL2 serum before use in immunotherapy decreased the number of DBA/2 mice surviving for more than 35 days an intraperitoneal injection with SL2 cells compared to the number of survivors inoculated with immune or hyperimmune cells only. These results show that, in immunotherapy with immune cells, we must consider the possibility that specific antitumor antibodies and antibodies not directed against the tumor cloud the therapeutic potnecy of the immune cells.