Statins for Primary Prevention in Adults Aged 75 Years or Older
Authors: Michelle C. Odden, Lee Goldman, Kirsten Bibbins-Domingo
Journal: Annals of Internal Medicine (2015)

Letters15 September 2015Statins for Primary Prevention in Adults Aged 75 Years or OlderMichelle C. Odden, PhD, Lee Goldman, MD, MPH, and Kirsten Bibbins-Domingo, MD, PhDMichelle C. Odden, PhDFrom Oregon State University, Corvallis, Oregon; College of Physicians and Surgeons, Columbia University, New York, New York; and University of California, San Francisco, California.Search for more papers by this author, Lee Goldman, MD, MPHFrom Oregon State University, Corvallis, Oregon; College of Physicians and Surgeons, Columbia University, New York, New York; and University of California, San Francisco, California.Search for more papers by this author, and Kirsten Bibbins-Domingo, MD, PhDFrom Oregon State University, Corvallis, Oregon; College of Physicians and Surgeons, Columbia University, New York, New York; and University of California, San Francisco, California.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/L15-5135-3 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail IN RESPONSE:Dr. Robinson's assertion that the amount by which statins reduce the risk for ischemic stroke is similar to that for CHD is unfortunately not borne out of what we believe are the best available data. PROSPER (Prospective Study of Pravastatin in the Elderly at Risk) (n = 5804; age, 70 to 82 years), the largest trial with a study population in the age range of that in our article, found no benefit of statins on stroke risk (hazard ratio, 1.03 [95% CI, 0.81 to 1.31]; P ...Reference1. Shepherd J, Blauw GJ, Murphy MB, Bollen EL, Buckley BM, Cobbe SM, et al; PROSPER study group.. PROspective Study of Pravastatin in the Elderly at Risk. Pravastatin in elderly individuals at risk of vascular disease (PROSPER): a randomised controlled trial. Lancet. 2002;360:1623-30. [PMID: 12457784] CrossrefMedlineGoogle Scholar Author, Article, and Disclosure InformationAuthors: Michelle C. Odden, PhD; Lee Goldman, MD, MPH; Kirsten Bibbins-Domingo, MD, PhDAffiliations: From Oregon State University, Corvallis, Oregon; College of Physicians and Surgeons, Columbia University, New York, New York; and University of California, San Francisco, California.Disclosures: Disclosures can be viewed at www.acponline.org/authors/icmje/ConflictOfInterestForms.do?msNum=M14-1430. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoCost-Effectiveness and Population Impact of Statins for Primary Prevention in Adults Aged 75 Years or Older in the United States Michelle C. Odden , Mark J. Pletcher , Pamela G. Coxson , Divya Thekkethala , David Guzman , David Heller , Lee Goldman , and Kirsten Bibbins-Domingo Statins for Primary Prevention in Adults Aged 75 Years or Older Jennifer G. Robinson Statins for Primary Prevention in Adults Aged 75 Years or Older Marcus M. Reidenberg Metrics Cited byStatin and clinical outcomes of primary prevention in individuals aged >75 years: The SCOPE-75 study 15 September 2015Volume 163, Issue 6Page: 482KeywordsCholesterolDietDisclosureElderlyExerciseIschemic strokeMedical risk factorsProspective studiesStatinsStroke ePublished: 15 September 2015 Issue Published: 15 September 2015 Copyright & PermissionsCopyright © 2015 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...