tbuckley/cabot-search huggingface dataset:
A case of chromoblastomycosis with an unusual clinical manifestation caused by Phialophora verrucosa on an unexposed area: treatment with a combination of amphotericin B and 5-flucytosine
Authors: S-G. Park, S-H. Oh, S-B. Suh, K-H. Lee, K-Y. Chung
Journal: British Journal of Dermatology (2005)

Chromoblastomycosis is a cutaneous and subcutaneous mycotic disease caused by the dematiaceous (black) fungi. Five species of fungi are known generally to be the cause: Fonsecaea pedrosoi, Phialophora verrucosa, Cladosporium carrionii, F. compacta and Rhinocladiella cerphilum. In infected tissue they can appear as pigmented sclerotic bodies, commonly called 'copper pennies', which are pathognomonic of chromoblastomycosis. The infection usually occurs through traumatic skin inoculation, with the majority of lesions occurring on the feet and legs of outdoor workers. We report a patient in whom the lesions had begun on the right breast, which is an unexposed area, without a history of trauma. A uniform, reliable treatment does not exist but our patient was mycologically cured with the use of amphotericin B and the subsequent combination of 5-flucytosine and itraconazole.
Reimbursement for Nosocomial Infections
Authors: JOHN M. BOYCE
Journal: Annals of Internal Medicine (1988)

Letters and Corrections1 May 1988Reimbursement for Nosocomial InfectionsJOHN M. BOYCE, M.D., LINDA DZIOBEK, R.N., GAIL POTTER-BYNOE, B.S.JOHN M. BOYCE, M.D.Search for more papers by this author, LINDA DZIOBEK, R.N.Search for more papers by this author, GAIL POTTER-BYNOE, B.S.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-108-5-776_1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: Under the prospective payment system, hospitals are reimbursed a fixed amount for each admission, based on the kind of surgical procedures done or the patient's diagnosis at admission (diagnosis-related group [DRG]). Approximately 50% of DRGs do not provide additional reimbursement if a complication such as nosocomial infection occurs. Estimated average costs per nosocomial infection range from $600 to $1800 (1-3). The impact of nosocomial infections on reimbursement patterns under the prospective payment plan is unclear because few data are available on the proportion of cases of nosocomial infections that fall into DRGs that provide additional payments for...References1. HALEYSCHABERGCROSSLEY RDK. Extra charges and prolongation of stay attributable to nosocomial infections: a prospective interhospital comparison. Am J Med. 1981;70:51-8. CrossrefMedlineGoogle Scholar2. BEYTTROXLERCAVANESS BSJ. Prospective payment and infection control. Infect Control. 1985;6:161-4. CrossrefMedlineGoogle Scholar3. HALEYWHITECULVERHUGHES RJDJ. The financial incentive for hospitals to prevent nosocomial infections under the prospective payment system: an empirical determination from a nationally representative sample. JAMA. 1987;257:1611-4. CrossrefMedlineGoogle Scholar4. . SENIC project: algorithms for diagnosing infections. Am J Epidemiol. 1980;111:635-43. CrossrefGoogle Scholar5. Outline for Surveillance and Control of Nosocomial Infections. Atlanta: Centers for Disease Control; 1972. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: JOHN M. BOYCE, M.D.; LINDA DZIOBEK, R.N.; GAIL POTTER-BYNOE, B.S.Affiliations: The Miriam Hospital and Brown University Providence, RI 02906 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byUnderresourced Hospital Infection Control and Prevention Programs: Penny Wise, Pound Foolish?A humanized monoclonal antibody targeting Staphylococcus aureusImmunotherapeutics for nosocomial infectionsThree scenarios of clinical claim reimbursement for nosocomial infection: the good, the bad, and the ugly 1 May 1988Volume 108, Issue 5Page: 776-776KeywordsDiagnosis related groupsFallsNosocomial infections ePublished: 1 December 2008 Issue Published: 1 May 1988 PDF downloadLoading ...
A randomized controlled trial of nurse follow-up clinics: do they help patients and do they free up consultants' time?
Authors: C. Gradwell, K.S. Thomas, J.S.C. English, H.C. Williams
Journal: British Journal of Dermatology (2002)

Background Nurse follow-up clinics have become increasingly popular in recent years. Their impact on service delivery within dermatology may be useful in relation to chronic diseases, where education and treatment concordance are important factors in disease management. Objectives To assess the impact of providing a nurse follow-up clinic in addition to the normal service provided by the dermatology outpatient department at Queen's Medical Centre, Nottingham, and to obtain pilot data with which to inform future study design. Methods Newly referred patients aged ≥ 14 years and with a diagnosis of either eczema or psoriasis were identified. In a randomized, parallel-group study with a follow-up period of 6 weeks, participants were randomized either to normal care, or to receive an additional session with a dermatology nurse specialist immediately after their consultation with the dermatologist. The primary outcome measure was change in quality of life at 6 weeks, as assessed by the Dermatology Life Quality Index (DLQI). Secondary outcomes comprised a comparison of patient knowledge at 6 weeks and the number of consultations (in secondary and primary care) that occurred during the 6-week follow-up period. Results Both groups improved by approximately 3 points on the DLQI scale after 6 weeks. The between-group difference was 0·27 (95% confidence interval − 2·3 to 2·8, P = 0·83). Patients who had seen the nurse were more likely to know how long they should apply treatment (P = 0·05). There was also a marked difference in patients' understanding of how to obtain a repeat prescription (P = 0·01) and from whom they could receive further support (P < 0·001). Following the addition of this service, 33% of follow-up appointments with a doctor were cancelled in the nurse intervention group. Conclusions Dermatology nurses can add to a dermatology consultation and provide effective patient education and support in managing a skin condition. With this added service nurses could help to free up dermatologists' time, thus allowing them to see more new patients. Cost-effectiveness studies are now needed.
Nephrotoxic and genotoxic N-acetyl-S-dichlorovinyl-L-cysteine is a urinary metabolite after occupational 1,1,2-trichloroethene exposure in humans: implications for the risk of trichloroethene exposure.
Authors: G Birner, S Vamvakas, W Dekant, D Henschler
Journal: Environmental Health Perspectives (1993)

Excretion of mercapturic acids in the urine is indicative of the formation of electrophiles in the metabolism of xenobiotics. The determination of these mercapturic acids thus may be a useful method to estimate the exposure. We identified the nephrotoxic and mutagenic mercapturic acids N-acetyl-S-(1,2-dichlorovinyl)-L- cysteine and N-acetyl-S-(2,2-dichlorovinyl)-L-cysteine in the urine of workers exposed to 1,1,2-trichloroethene. A method to quantify these mercapturic acids by gas chromatography-mass spectrometry-selected ion monitoring was developed and appreciable amounts (2.8-3.8 mumole/L were found in human urine samples. Because deacetylation determines notably the amount of the excreted mercapturic acids, the formation of the resulting cysteine S-conjugates was comparably measured in subcellular fractions of rodent and human kidneys; significant species differences in acylase activity were found. The formation of mutagenic and nephrotoxic metabolites during 1,1,2-trichloroethene metabolism mandates a revision of the risk assessment of trichloroethene exposure.
RECENT ADVANCES IN SURGERY FOR EMPHYSEMA
Authors: Stephen S. Lefrak, MD, Roger D. Yusen, MD, Elbert P. Trulock, MD, Mary S. Pohl, RN MHS, Alexander Patterson, MD, Joel D. Cooper, MD
Journal: Annual Review of Medicine (1997)

▪ Abstract Volume reduction surgery is based on the removal of volume-occupying but nonfunctioning emphysematous lung, which is thought to improve pulmonary elastic recoil. The reduction in thoracic volume may also improve thoracic cage and inspiratory muscle function. In addition, dyspnea is lessened, exercise tolerance is increased, and measured pulmonary function is improved. Alveolar gas exchange may also be improved. Selection criteria include marked airway obstruction secondary to emphysema, marked hyperinflation of the chest wall, and regional heterogeneity in the distribution of the emphysema. The best results are obtained with a bilateral procedure utilizing stapling resection. The two surgical approaches are median sternotomy and video-assisted thoracic surgery.
Middle East Respiratory Syndrome coronavirus (MERS-CoV) serology in major livestock species in an affected region in Jordan, June to September 2013
Authors: C B Reusken, M Ababneh, V S Raj, B Meyer, A Eljarah, S Abutarbush, G J Godeke, T M Bestebroer, I Zutt, M A Müller, B J Bosch, P J Rottier, A D Osterhaus, C Drosten, B L Haagmans, M P Koopmans
Journal: Eurosurveillance (2013)

Between June and September 2013, sera from 11 dromedary camels, 150 goats, 126 sheep and 91 cows were collected in Jordan, where the first human Middle-East respiratory syndrome (MERS) cluster appeared in 2012. All sera were tested for MERS-coronavirus (MERS-CoV) specific antibodies by protein microarray with confirmation by virus neutralisation. Neutralising antibodies were found in all camel sera while sera from goats and cattle tested negative. Although six sheep sera reacted with MERS-CoV antigen, neutralising antibodies were not detected.
Paper free hospital leads the way
Authors: B Christie
Journal: BMJ (1994)

The most expensive private hospital to be built in Britain has abandoned the use of paper medical records after developing what it claims is the first fully integrated computer based records system in the world. The specialists who have worked on the project believe that it signals the end of cumbersome and inefficient paper based records and that the system should be available at a price that can be afforded by most Western hospitals.

The development work has taken place at a state of the art hospital built over the past three years on the …
Connective tissue disease-associated pulmonary arterial hypertension: “Beijing style”
Authors: Lorinda Chung, Steven M. Kawut
Journal: European Respiratory Journal (2014)

Survival rates of CTD-APAH patients in China in the modern treatment era are similar to those in the USA and Europe http://ow.ly/xXCZuPatients with connective tissue disease (CTD)-associated pulmonary arterial hypertension (APAH) experience poorer outcomes than those with idiopathic PAH (IPAH) [1-6].In the USA, patients with systemic sclerosis (SSc) are most commonly affected by CTD-APAH and have the worst survival [1].Similarly, 74% of a large cohort with CTD-APAH in the UK had SSc, and these patients had poorer survival than those with systemic lupus erythematosus (SLE) or polymyositis/dermatomyositis [7].Few published studies have described the clinical features and outcomes of patients with CTD-APAH in Asia.CHUNG et al. [8] found that Korean patients with SLE-pulmonary hypertension had much worse survival than those with IPAH, with 1-and 5-year survival rates of 51% and 17% for SLE-pulmonary hypertension compared with 77% and 68% for IPAH.A more recent study of 70 Japanese patients with CTD-APAH found that mixed connective tissue disease (MCTD) was the most common underlying CTD (43%), followed by SLE (29%), SSc (19%) and primary Sjogren's syndrome (10%) [9].This study found no significant difference in survival among the different CTD-APAH subgroups, but did find improved survival rates in those diagnosed more recently.In this issue of the European Respiratory Journal, HAO et al.[10] describe the clinical features and outcomes of 129 Chinese patients with CTD-APAH confirmed by right heart catheterisation between July 2006 and May 2011.It is known that the prevalence of SLE in the Chinese population is much higher than in Caucasians [11,12], while SSc is more common in Caucasians than in the Chinese population [13].Consistent with this epidemiology, SLE was the most common underlying CTD (49% of the study sample), followed by primary Sjogren's syndrome (16%), MCTD (9%) and SSc (6%).This study also included patients with Takayasu's arteritis (12%), an inflammatory vasculitis of the large vessels.Compared with USA and European cohorts of CTD-APAH [1,6,7], the Chinese patients were younger, with a mean age of 39.3¡12.3 years compared with 57.1¡13.7 years in the REVEAL CTD-APAH group [1], possibly reflecting the patterns of underlying CTD in the different regions.Similar to western cohorts, the majority of patients were female.Although fewer patients were in World Health Organization (WHO) functional class III/ IV (56.6% versus 73.5% in REVEAL), overall haemodynamics were comparable in the Chinese group compared with the REVEAL CTD-APAH patients.Diffusing capacity of the lung for carbon monoxide, a key prognostic factor in patients with SSc-APAH [14], was much higher in the Chinese CTD-APAH patients.
Enhancement of the hepatotoxicity of chloroform in B6C3F1 mice by corn oil: implications for chloroform carcinogenesis.
Authors: R J Bull, J M Brown, E A Meierhenry, T A Jorgenson, M Robinson, J A Stober
Journal: Environmental Health Perspectives (1986)

A recent study of the ability of chloroform in drinking water to produce cancer reported that male Osborne-Mendel rats developed renal tumors, but that female B6C3F1 mice failed to develop hepatocellular carcinomas. The results obtained in the male Osborne-Mendel rats were comparable to those observed in an earlier study sponsored by the National Cancer Institute (NCI). On the other hand, the lack of an increased incidence of hepatocellular carcinomas in female B6C3F1 mice was in sharp contrast to previously reported results. The doses of chloroform used were comparable to that which produced an 85% incidence in the NCI study. We have investigated the extent to which the vehicle might be responsible for the different results in these two studies by examining the differential effects of chloroform when it was administered by gavage using corn oil versus a 2% Emulphor suspension as the vehicle. Male and female B6C3F1 mice were administered chloroform at 60, 130, and 270 mg/kg per day for 90 days. At sacrifice, body and organ weights were measured, and blood was recovered to perform the following serum chemistry measurements (in order of priority): glutamate oxalacetate transaminase (SGOT), lactate dehydrogenase (LDH), blood urea nitrogen (BUN), and triglyceride (TG) levels. The liver was sectioned for histopathological examination. Chloroform increased SGOT levels significantly only when administered in corn oil at a dose of 270 mg/kg in both male and female mice. It had no effect on LDH activity. There was a small increase in BUN when chloroform was administered in corn oil, but not when administered in 2% Emulphor. When administered in corn oil, chloroform significantly decreased serum TG levels but was without effect on this parameter when administered in 2% Emulphor. Chloroform decreased body weight and increased liver weight with both vehicles, but the effects were significantly greater when it was administered in corn oil. Mice administered chloroform in corn oil displayed a significant degree of diffuse parenchymal degeneration (5 of 10 males and 1 of 10 females) and mild to moderate early cirrhosis (5 of 10 males and 9 of 10 females); significant pathological lesions were not observed in the animals administered corn oil without chloroform nor in mice receiving chloroform in 2% Emulphor. These data indicate that administration of chloroform by corn oil gavage results in more marked hepatotoxic effects than observed when it is provided in an aqueous suspension.(ABSTRACT TRUNCATED AT 400 WORDS)
PERIDENTAL MEMBRANE AND VITALITY OF TEETH
Authors: H. A. Tuckey
Journal: JAMA (1925)

To the Editor:  —InThe Journalof Dec. 13, 1924, the comment regarding  teeth should not go unchallenged.  In the issue of January 17, Dr. Byron C. Darling expresses the whole matter of the diseased tooth problem as it concerns the physician:  As to the term dead teeth, the matter is equally debatable. Since common practice for centuries has recognized these as dead teeth, certainly the burden of proof is on those who would make it out otherwise. To be sure, such teeth are not all exfoliated at once; but they are shown, even so, to be the depository of the potential source of infection in the majority of cases, after six months or a year, whether with canals filled and no evidence of disease, or cured by the dental treatments. This subject has been covered many times from many angles, as shown by the literature of Rosenow, Duke,
In Zambia: Doing More with Less
Authors: H. GILBERT WELCH
Journal: Annals of Internal Medicine (1983)

Abroad1 April 1983In Zambia: Doing More with LessH. GILBERT WELCH, M.D.H. GILBERT WELCH, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-98-4-551 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptAn Anglican Mission Hospital sits on the high plateau of Zambia's eastern province. A vestige of British rule, it maintains a distinctly colonial atmosphere. The over 30 acres of meticulously kept grounds provide a lush backdrop for the rambling brick hospital and the compact personal residences of its predominantly British and Dutch senior staff. The scene is not unlike that of a small New England prep school. Morning and afternoon teas are a daily routine.At first glance, St. Francis hospital does not appear to be the kind of place that would offer a lesson on limited resources. Yet this... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Conemaugh Valley Memorial Hospital Johnstown, Pennsylvania PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByMedicine in ZambiaGARY GILBERT, M.D. 1 April 1983Volume 98, Issue 4Page: 551-552KeywordsPreexposure prophylaxisTea Issue Published: 1 April 1983 PDF DownloadLoading ...
Identification of 2 major loci linked to autoimmune hemolytic anemia in NZB mice
Authors: Shuichi Kikuchi, Hirofumi Amano, Eri Amano, Liliane Fossati-Jimack, Marie-Laure Santiago-Raber, Thomas Moll, Akinori Ida, Brian L. Kotzin, Shozo Izui
Journal: Blood (2005)
ST. GEORGE'S HOSPITAL: DROPSY: ULCERATION OF INTESTINES: CONGESTION AND SUBSEQUENT ATROPHY (?) OF LIVER
Authors: J. A. Wilson
Journal: BMJ (1856)

He stated that he suffered eighteen months ago from severe diarrhoa, which continued nine months, and then entirely ceased, leaving him in a very exhausted condition, and subject to frequent fits of giddiness.But his complaint when he came to the hospital was of dull heavy pain at the epigastrium, general debility, and tendency to cedema of the legs.These symp- toms had manifested themselves five months before admis- sion.The dropsy was rapidly increasing, and his legs and
The European Respiratory Journal makes COPD a priority
Authors: J.B. Soriano, V. Brusasco, A.T. Dinh-Xuan
Journal: European Respiratory Journal (2011)

hronic obstructive pulmonary disease (COPD) represents a major problem for public health worldwide and its burden is expected to increase in the next decade.Despite the extensive resources invested in research and the wealth of studies published in leading scientific journals, there are still many unknown aspects regarding the nature of COPD, which make this disease difficult to treat.A number of authors and societies have recently outlined some of the burning questions on COPD that need to be addressed by researchers in order to reduce the burden of the disease and help funding agencies to prioritise limited resources in competitive calls.They include documents from the American Thoracic Society (ATS)/European Respiratory Society (ERS) [1, 2], the Global Alliance against Chronic Respiratory Diseases (GARD) [3], the International Primary Care Research Group [4] and the American Journal of Respiratory and Critical Care Medicine [5,6].The number of indexed respiratory journals has substantially increased in the past few years and some also incorporate COPD in their title, which allows more room for articles on this disease.The European Respiratory Journal (ERJ) has already published many papers on COPD and is eager to publish more, and better, research on this topic in the near future.However, we must keep in mind that space is limited and the competition for priority is tough among manuscripts in different fields.The ERJ can currently accept less than 15% of submitted manuscripts, and immediate rejection without external peer review is becoming a painful but necessary measure given the overload of manuscripts not focused on sufficiently relevant questions.We understand that, after the time-consuming task of formatting text, tables and figures, collecting signed forms, and then uploading it all in a web server, no one enjoys a same-day response of ''No thanks''.
Hydroxychloroquine treatment for primary Sjogren's syndrome: a two year double blind crossover trial.
Authors: A A Kruize, R J Hene, C G Kallenberg, O P van Bijsterveld, A van der Heide, L Kater, J W Bijlsma
Journal: Annals of the Rheumatic Diseases (1993)

OBJECTIVES--In 1985 and 1988 a positive effect of treatment of primary Sjögren9s syndrome with hydroxychloroquine was reported in two small open studies. To investigate further the clinical and laboratory effects of hydroxychloroquine in primary Sjögren9s syndrome a two year study was performed. METHODS--The design of the study included a prospective, placebo controlled, two year double blind crossover trial in 19 patients. RESULTS--A significant decrease in IgG and IgM and a tendency for a decrease in the erythrocyte sedimentation rate (ESR) during treatment with hydroxychloroquine compared with treatment with placebo were found. No beneficial clinical effect of the use of hydroxychloroquine as expressed in preference for treatment with hydroxychloroquine or placebo with regard to symptoms and signs of primary Sjögren9s syndrome could be shown, however, nor any relevant change in tear gland activity and sequelae of peripheral tear function deficiency, nor salivary gland scintigraphy. CONCLUSIONS--The use of hydroxychloroquine at a dose of 400 mg daily taken over a 12 month period does not have a worthwhile clinical benefit in patients with primary Sjögren9s syndrome despite an improvement of hyperglobulinaemia and slight changes in the ESR and IgM.
Biologics in nail psoriasis
Authors: D. Berker
Journal: British Journal of Dermatology (2014)

Journal Article Biologics in nail psoriasis Get access D. de Berker D. de Berker Bristol Dermatology Centre University Hospitals Bristol Bristol BS2 8HW U.K Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 170, Issue 2, 1 February 2014, Pages 236–237, https://doi.org/10.1111/bjd.12752 Published: 01 February 2014