VASOPRESSOR COMPONENTS OF PHEOCHROMOCYTOMAS
Authors: K H BEYER, C A ROSS, V D WIEBELHAUS, W S WALLER, G S SCHUCHARDT
Journal: Annals of Internal Medicine (1951)

Article1 July 1951VASOPRESSOR COMPONENTS OF PHEOCHROMOCYTOMASKARL H. BEYER, Ph.D., M.D., F.A.C.P., CHARLES A. ROSS, M.S., VIRGIL D. WIEBELHAUS, Ph.D., WILLIAM S. WALLER, B.S., GRACE S. SCHUCHARDT, B.S.KARL H. BEYER, Ph.D., M.D., F.A.C.P.Search for more papers by this author, CHARLES A. ROSS, M.S.Search for more papers by this author, VIRGIL D. WIEBELHAUS, Ph.D.Search for more papers by this author, WILLIAM S. WALLER, B.S.Search for more papers by this author, GRACE S. SCHUCHARDT, B.S.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-35-1-117 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe purpose of this report is to present analyses of the pressor amine content of two pheochromocytomas and the metabolism of the hypertensive agents in these and a third tumor. Probably none of the reports of the epinephrine content of pheochromocytomas prior to the past few months is valid, qualitatively. The lack of specificity of the bioassay or chemical methods as they were used in the past did not differentiate that hormone from related compounds having similar biologic or chemical properties. Present evidence indicates that epinephrine may not even be the predominant pressor agent in some of these tumors. The...Bibliography1a. CannonRosenblueth WBA: Studies on conditions of activity in endocrine organs; sympathin E and sympathin I, Am. J. Physiol. 104: 557-574, 1933. b. Cannon, W. B., and Rosenblueth, A.: Autonomic neuroeffector systems, 1937, The Macmillan Co., New York. CrossrefGoogle Scholar2a. AbelCrawford JJAC: On the blood-pressure-raising constituent of the suprarenal capsule, Bull. Johns Hopkins Hosp. 8: 151-157, 1897. b. Abel, J. J.: Ueber den blutdruckerregenden Bestandtheil der Nebenniere, das Epinephrin, Ztschr. f. physiol. 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SHOEMAKER, Ph.D., STEWART WOLF, M.D., F.A.C.P.Clinical Applications of Adrenergic Blockade in Vascular Diseases With Special Reference To Dibenamine and 688a 1 July 1951Volume 35, Issue 1Page: 117-133KeywordsBioassays and physiological analysisBiologicsDrug research and developmentEpinephrineHormonesPharmacologyPheochromocytomaSpecificityUrineVasopressors ePublished: 1 December 2008 Issue Published: 1 July 1951 PDF downloadLoading ...