ABNORMALITIES OF PULMONARY GAS EXCHANGE IN OBESITY
Authors: S I SAID
Journal: Annals of Internal Medicine (1960)

Article1 December 1960ABNORMALITIES OF PULMONARY GAS EXCHANGE IN OBESITYSAMI I. SAID, M.D.SAMI I. SAID, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-53-6-1121 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptIn 1955 a clinical "syndrome" was described that consisted of extreme obesity, hypoventilation, arterial hypoxia, polycythemia, and right heart failure.1Since then the physiologic mechanisms by which obesity could interfere with cardiorespiratory function have been under study.2-17Most reports have dealt with obese patients showing clinical evidence of dysfunction, and who were, therefore, probably in an advanced stage of the disorder. In an effort to elucidate the sequence of events that ultimately lead to the development in the obese of the so-called "pickwickian syndrome," we set out to study a group of subjects selected solely because of their marked obesity....Bibliography1. SiekerEstesKelserMcIntosh HOEHGAHD: A cardiopulmonary syndrome associated with extreme obesity, J. Clin. Investigation 34: 916, 1955. Google Scholar2. AuchinclossCookRenzetti JHEA: Polycythemia of unknown cause with alveolar hypoventilation, Clin. Res. Proc. 3: 31, 1955. Google Scholar3. AuchinclossCookRenzetti JHEAD: Clinical and physiological aspects of a case of obesity, polycythemia and alveolar hypoventilation, J. Clin. Investigation 34: 1537, 1955. CrossrefMedlineGoogle Scholar4. JohnsonLelleheiMiller RLJPWF: Cardiopulmonary changes associated with extreme obesity and polycythemia, Clin. Res. Proc. 4: 47, 1956. Google Scholar5. 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Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Richmond, Virginia*Received for publication April 29, 1960.Presented at the Forty-first Annual Session of The American College of Physicians, San Francisco, California, April 6, 1960.From the Department of Medicine, Medical College of Virginia, Richmond, Virginia.†This study was supported by grants from the National Heart Institute of the U. S. Public Health Service (H-4226), and from the Richmond Area Heart Association.Requests for reprints should be addressed to Sami I. Said, M.D., Department of Medicine, Medical College of Virginia, Richmond 19, Virginia.‡Warren E. Collins, Inc. 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