CLINICAL OBSERVATIONS WITH FAGARINE
Authors: D SCHERF, A M SILVER, L D WEINBERG
Journal: Annals of Internal Medicine (1949)

Article1 January 1949CLINICAL OBSERVATIONS WITH FAGARINED. SCHERF, F.A.C.P., A. M. SILVER, L. D. WEINBERGD. SCHERF, F.A.C.P.Search for more papers by this author, A. M. SILVERSearch for more papers by this author, L. D. WEINBERGSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-30-1-100 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptAlthough there has been considerable progress in therapy recently, new remedies for the treatment of cardiac arrhythmias deserve attention. Anyone who has seen a patient die as the result of persistently rapid heart rate in a paroxysmal tachycardia, refractory to digitalis, quinidine, and other drugs even in large doses, will welcome a new therapeutic agent.Alpha-fagarine hydrochloride† an alkaloid extracted from the Argentinean plant Fagara coco, has been recommended for certain disturbances of stimulus formation.1 It has been used in man,10, 11 and available reports suggested that further studies of the drug were justified.METHODDuring the clinical use of...Bibliography1. DEULOFEULABRIOLAORIASMOISSET DE ESPANESTACQUINI VROEA: Fagarine, a possible substitute for quinidine, Science, 1945, cii, 69. CrossrefGoogle Scholar2. DIPALMALAMBERT JJJ: Importance of the methoxy group in antifibrillatory compounds, Science, 1948, cvii, 66. CrossrefGoogle Scholar3. GALLAVARDIN L: Extra-systolie ventriculaire à paroxysmes tachycardiaques prolongés, Arch. d. mal. du coeur, 1922, xv, 15. Google Scholar4. MOISSET DE ESPANES E: Action de la fagarine I et de la quinidine sur la fibrillation ventriculaire primaire produite par l'occlusion coronarienne expérimentale, Compt. rend. Soc. de biol., 1938, cxxvii, 233. Google Scholar5. MOISSET DE ESPANESMOYANO NAVARRO EB: Action cardiaque et hemodynamique de la fagarine I, Compt. rend. Soc. de biol., 1938, cxxvii, 510. Google Scholar6. SCHERF D: The effect of fagarine on auricular fibrillation and flutter, Proc. Soc. Exper. Biol. and Med., 1948, xvii, 59. CrossrefGoogle Scholar7. SCHERFBOYD DLJ: Clinical electrocardiography, 2d ed., 1946, Lippincott, Philadelphia. Google Scholar8. SCHWARTZJEZER SPA: The action of quinine and quinidine on patients with transient ventricular fibrillation, Am. Heart Jr., 1934, ix, 792. CrossrefGoogle Scholar9. STUCKERTSARTORI GA: Rev. Univ. Nac Cardoba, Argentina, 1932, xix, 12. Google Scholar10. TACQUINI AC: Tratamiento de la fibrilacion y del aleteo auriculares con clorhidrato de fagarina, Rev. argent. de cardiol., 1945, xii, 83. Google Scholar11. TACQUINI AC: Fagarine—a new drug for the treatment of auricular fibrillation and flutter, Am. Heart Jr., 1947, xxxiii, 719. Google Scholar12. WILSONWISHART FNSW: Effects produced by the intravenous injection of quinidine and other drugs upon the mechanism of the heart beat, Trans. Assoc. Am. Phys., 1926, xli, 55. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: New York, N. Y.*Received for publication March 20, 1948.Aided by a Grant from Bernhard Altmann.From the Department of Medicine, the New York Medical College, New York, N. Y.†We are grateful to the Laboratorias Apotarg in Cordoba, Argentine, for the supply of alpha-fagarine hydrochloride used in our study. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byPrevention of the cardiotoxic effect of quinidine by isoproterenolDie Rhythmusstörungen des Herzens (einschließlich der intramuralen Leitungsstörungen und des Alternans)A correlation between the therapeutic effectiveness of certain drugs in atrial fibrillation and their action on myocardial conductionChloroquineChapter 39 Cardioactive AlkaloidsTreatment of Cardiac ArrhythmiasThe action of procaine amide in complete heart blockUse of pronestyl in the treatment of ectopic rhythmsAtrial flutterMeasures Used in the Prevention and Treatment of Cardiac Arrhythmias 1 January 1949Volume 30, Issue 1Page: 100-120KeywordsAlkaloidsArrhythmiaDrugsHeart rateTachycardia ePublished: 1 December 2008 Issue Published: 1 January 1949 PDF downloadLoading ...