tbuckley/cabot-search huggingface dataset:
Psychological intervention (PsychInt) in pulmonary rehabilitation (PR) is effective on anxiety and depression
Authors: Gianluigi Balestroni, Sabine Seemayer, Giovanna Omarini, Pierangela Omarini, Mara Paneroni, Michele Vitacca, Bruno Balbi
Journal: European Respiratory Journal (2014)

Patients undergoing PR may frequently have anxiety and depression, cognitive dysfunction and often need an educational approach to their respiratory disorder. We determined psychological symptoms, cognitive status and educational proficiency in patients with COPD and evaluated if a PsychInt inside a PR program is associated with changes in emotional status. Sixty COPD patients (66±10 years, 35 men, 46 retired and 52 with a medium-low educational level) consecutively admitted for the first time to our in-patient PR Dept. were evaluated on admission (Adm) and discharge (Dch) by means of different validated questionnaires: MOCA (cognitive dysfunction), HADS (anxiety and depression), EQ-5D (quality of life, QoL) and an educational questionnaire (Paneroni M et al. Respir Care 2013; 58:327-333). PsychInt consisted in support individual interviews and counseling, training of relaxation groups, educational programme. After PR we observed a significant improvement in anxiety (Adm 50% of patients with an anxiety score vs. Dch 20%, p=0.01). Similar data were present for depression (63% vs. 40%, p=0.03). QoL improved significantly (59.6 vs 71.0, p=0.01). No change was observed for the MOCA questionnaire (%positive score 63.3 vs. 61.7) and for the Educational Questionnaire (% of corrected answers 76.5 vs. 79.8). A structured PsychInt during a PR program can effectively ameliorate anxiety, depression and QoL. Cognitive dysfunction is a real issue in PR patients and obviously PsychInt is not able to induce changes on it. Educational activities are integral part of a PR program and should be evaluated by means of specific questionnaires.
Abstract 13984: What’s the Best Age for Mice to Have Myocardial Infarction: Modulating Matrix Metalloproteinase-9 to Answer the Question
Authors: Andriy Yabluchanskiy, Yonggang Ma, Dustin Bratton, Ying A Chiao, Andrew Voorhees, Hai-Chao Han, Yu-Fang Jin, Merry L Lindsey
Journal: Circulation (2014)

Previously, we reported that matrix metalloproteinase-9 (MMP-9) levels increase post-myocardial infarction (MI), and MMP-9 deletion in young mice attenuates remodeling of the left ventricle (LV) and improves cardiac function post-MI. We also showed that MMP-9 increases with age, accompanied by decreased end diastolic function. In this study, we investigated the effects of MMP-9 deletion on LV remodeling post-MI in aged mice. We enrolled 95 C57BL/6J (WT) and 91 MMP-9 null (null) mice of both sexes at 11 to 36 months of age, which in humans is the equivalent of 30 to 100 years of age. WT and null mice were analyzed at day 7 post-MI. The infarct area was similar (47±7% for WT and 46±6% for null; p=0.34) indicating equal initial ischemic stimuli. Post-MI, plasma MMP-9 levels were significantly increased and positively correlated with age in WT mice (r=0.46, p=0.001) but not null (r=0.08, p=0.11). Similar to young mice, MMP-9 deletion improved survival at day 7 post-MI (89% vs. 77% for WT, p=0.01). Regression ...
HEMANGIOENDOTHELIOSARCOMA OF THE ILEUM WITH METASTASES TO THE RIGHT AURICLE, RUPTURE OF THE HEART, AND HEMOPERICARDIUM AT LEAST 10 DAYS BEFORE DEATH: A CASE REPORT
Authors: R R GRAYSON
Journal: Annals of Internal Medicine (1954)

Case Reports1 July 1954HEMANGIOENDOTHELIOSARCOMA OF THE ILEUM WITH METASTASES TO THE RIGHT AURICLE, RUPTURE OF THE HEART, AND HEMOPERICARDIUM AT LEAST 10 DAYS BEFORE DEATH: A CASE REPORTRICHARD R. GRAYSON, M.D.RICHARD R. GRAYSON, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-41-1-151 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptA careful review of the available literature fails to reveal a case similar to the one presented in this paper. Because of the exceeding rarity of hemangioendotheliosarcoma, and the unique complication of rupture of the heart due to metastatic involvement of the right auricle, this case is considered worthy of reporting.Incidence:Sarcoma of any kind of the small intestine is rare,2and hemangioendothelioma itself is rare among the sarcomas.3"In the New England Deaconess and Palmer Memorial Hospitals from 1927 to 1939, Medinger was able to find only 10 malignant tumors of the small intestine at autopsy and in...Bibliography1. MaxwellCrileDinsmore EAGRS: Malignant tumors of the small intestine, S. Clin. North America 28: 1149-1157 (Oct.) 1948. CrossrefMedlineGoogle Scholar2. FrankMillerBell LWASJC: Sarcoma of the small intestine, Ann. Surg. 115: 544-565, 1942. CrossrefMedlineGoogle Scholar3. Kastl WH: Hemangioma with diffuse involvement of spleen and bone; case report, Ann. Surg. 133: 561-564, 1951. CrossrefMedlineGoogle Scholar4. LeggFitch QSWM: Hemangioendothelioma: review of the literature with a report of two cases, South. Surgeon 26: 803-811, 1950. Google Scholar5. Nielsen OS: Primary hemangioendotheliosarcoma in the liver of children, Acta paediat. 40: 431-438 (Sept.) 1951. CrossrefMedlineGoogle Scholar6. Stein JJ: Tumors of the small intestine: a review of the literature and report of eight additional cases, Am. J. Digest. Dis. 4: 517-522 (Oct.) 1937. CrossrefGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Perryville, Missouri*Received for publication September 9, 1953. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byHaemangiomatosis of the small and large bowel with histological malignant changeAngiosarcoma of the heartNontraumatic hemopericardiumPRIMARY HEMANGIO-ENDOTHELIOMA OF THE HEART*JAMES F. CRENSHAW, M.D., EDMUND A. DOWLING, M.D., W. F. CRESSWELL JR., M.D.Rupture of the Heart after Myocardial Infarction 1 July 1954Volume 41, Issue 1Page: 151-159KeywordsAutopsyHeartIleumMalignant tumorsSarcomaSmall intestine ePublished: 1 December 2008 Issue Published: 1 July 1954 PDF downloadLoading ...
Drug points: Tachycardia associated with moxifloxacin
Authors: M. Siepmann
Journal: BMJ (2001)

The fluoroqinolone grepafloxacin has been associated with tachycardia in animals and humans. 1 2 It was eventually withdrawn from use owing to prolongation of the QT interval. Another fluoroquinolone, moxifloxacin (Avalox, Bayer Vital), was introduced in Germany in September 1999 and two months later in the United States. The chemical structure of moxifloxacin is similar to that of grepafloxacin, and both drugs have …
Controversies in Management: Screening asymptomatic people at high risk for hepatitis C
Authors: C. A Seymour
Journal: BMJ (1996)

In some respects hepatitis C is hepatitis B revisited. Years after the discovery of hepatitis B virus and 11 years after development of a safe, efficacious vaccine, consensus has emerged in the international health community that decisive global action against hepatitis B is a necessity.1 Those who doubt that a similar approach will be needed towards hepatitis C point to a relative lack of knowledge of the clinical course of hepatitis C and the efficacy of treatment.

In 1989 hepatitis C virus was cloned and characterised as a positive sense, single stranded RNA genome containing 9400 nucleotides. It is a major cause of post-transfusion hepatitis2; up to 50% of patients commonly progress to chronic hepatitis and 20% to cirrhosis with secondary complications such as hepatocellular carcinoma.3 A problem arises because hepatitis C may have a progressive course to chronic disease occurring over decades, during which time the individual may be symptom free and the disease remain undiagnosed until the patient presents with liver disease or its complications.2 3

In the United States 3.5 million people are estimated to have chronic hepatitis C; of these, 8000-10000 die of liver related complications and 1000 undergo liver transplantation.4 Around 23% of patients given a transplant had hepatitis C virus, and 19% of those given transplants for seronegative cryptogenic cirrhosis developed hepatitis C after transplantation.4 5 Prevalence is similar in Europe and higher in Japan and other eastern countries.

The hepatitis C virus is transmitted parenterally through blood, blood products, injecting drug misuse, and tattooing, as well as by sexual6 and household transmission. Serological identification of hepatitis C virus by second and …
Abstract 3801: Small molecule inhibitor of Stat3 induces antitumor cell effects <i>in vitro</i> and antitumor effects <i>in vivo</i> against human glioma or breast cancer model
Authors: Peibin Yue, Francisco Lopez-Tapia, Marcus Tius, James Turkson
Journal: Cancer Research (2014)

Abstract Aberrant activation of signal transducer and activator of transcription 3 (Stat3) is prevalent in many human cancers. Compelling evidence shows that constitutively-active Stat3 constitutes a point of convergence in oncogenic tyrosine kinase signaling, functioning as a master regulator of events crucial for tumorigenesis and malignant progression. We show herein that the small-molecule, SH5-07 abrogates constitutive activation of Stat3 and Stat3-dependent functions in human glioma and breast cancer cells. SH5-07 inhibits in vitro Stat3 DNA-binding activity with an IC50 value of 3.9 μM. Treatment of human glioma U251MG and breast cancer MDA-MB-231 cells that harbor aberrantly-active Stat3 with low micromolar SH5-07 blocks Stat3 phosphorylation, DNA-binding, and transcriptional activities in a time and dose-dependent manner. By contrast, SH5-07 shows little or no effect on the induction of pJAK2, pSrc, pErk1/2, and pShc in glioma and breast cancer cells. SH5-07 preferentially inhibited viability of human glioma and breast cancer cells that harbor aberrant Stat3 activity, with IC50 of 1.1-5.2 µM, compared to IC50 of 6.0-10.8 µM for cells that do not. Inhibition of aberrantly-active Stat3 by SH5-07 preferentially suppresses the anchorage-dependent and independent growth, induces apoptosis, and blocks migration and invasion in vitro of human glioma and breast cancer cells that harbor constitutively-active Stat3. Moreover, oral administration of SH5-07 inhibits the growth of human breast tumor xenografts in mice. Data together indicates SH5-07 is a promising small-molecule Stat3 inhibitor and a suitable drug candidate for clinical development. Citation Format: Peibin Yue, Francisco Lopez-Tapia, Marcus Tius, James Turkson. Small molecule inhibitor of Stat3 induces antitumor cell effects in vitro and antitumor effects in vivo against human glioma or breast cancer model. [abstract]. In: Proceedings of the 105th Annual Meeting of the American Association for Cancer Research; 2014 Apr 5-9; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2014;74(19 Suppl):Abstract nr 3801. doi:10.1158/1538-7445.AM2014-3801
Expiratory flow limitation (EFL) detected non-invasively as a phenotypic characteristic of COPD
Authors: Bernt Bøgvald Aarli, Peter M.A. Calverley, Tomal Mikal Lind Eagan, Per Sigvald Bakke, Jon Andrew Hardie
Journal: European Respiratory Journal (2011)

Within-breath change in reactance at 5Hz during tidal breathing reliably detects EFL in patients with COPD. We used the method proposed by Dellaca et al to determine presence of EFL and its relationship to spirometry and demographics of 424 healthy smokers and COPD patients from the Bergen cohort of the ECLIPSE study.

Aim: Establish the prevalence of EFL by GOLD stage and its relationship to dyspnoea and BMI.

274 stable COPD patients and 150 healthy smoking controls performed spirometry and tidal impulse oscillometry.

Results: Presence of EFL in healthy smokers, COPD grade 2,3, and 4 was.7%, 13%, 28% and 40% respectively. Inspiratory resistance and reactance at 5Hz were higher in COPD than smokers but differed little across GOLD stages.

View this table:

Demographics





Conclusion: EFL became more common in higher GOLD stages, but a significant number of patiens in all GOLD stages were not flow limited at rest. In GOLD stage 2 and 3 EFL patients were more breathless, despite similar spirometry, but EFL also tracked obesity, which may contribute to both EFL and dyspnoea. Presence of EFL has potential to be an independent phenotypic characteristic in stable COPD.
Incidence and Correlates of Drug-Eluting Stent Thrombosis in Routine Clinical Practice
Authors: Peter Wenaweser, Joost Daemen, Marcel Zwahlen, Ron van Domburg, Peter Jüni, Sophia Vaina, Gerrit Hellige, Keiichi Tsuchida, Cyrill Morger, Eric Boersma, Neville Kukreja, Bernhard Meier, Patrick W. Serruys, Stephan Windecker
Journal: Journal of the American College of Cardiology (2008)
Human immunodeficiency virus-1 B and non-B subtypes with the same drug resistance pattern respond similarly to antiretroviral therapy
Authors: M. Franzetti, M. Violin, G. Casazza, G. Meini, A. Callegaro, P. Corsi, F. Maggiolo, A.R. Pignataro, S. Paolucci, N. Gianotti, D. Francisci, R. Rossotti, G. Filice, T. Carli, M. Zazzi, C. Balotta
Journal: Clinical Microbiology and Infection (2011)
Abstract 18802: All-Cause Mortality in Normal Weight Type 2 Diabetes: A Meta-Analysis of Longitudinal Cohort Studies
Authors: Mercedes R Carnethon, Peter John C de Chavez, Alan R Dyer, Alain G Bertoni, Mary L Biggs, Brenda W Campbell-Jenkins, Sherita H Golden, Cora E Lewis, Kiang Liu, Kenneth J Mukamal
Journal: Circulation (2010)

Objective: Type 2 diabetes (T2DM) in normal weight (body mass index<25kg/m2) is an intriguing representation of the metabolically obese normal weight phenotype. Because the prevalence of normal wei...
Effect of Cortisone on Growth, DNA, RNA, and Protein of Spontaneous and Transplanted Mammary Tumors in Mice
Authors: A. F. Burton, R. W. Begg
Journal: JNCI Journal of the National Cancer Institute (1961)

The influence of cortisone upon the growth and metabolism of spontaneous and transplanted mammary tumors in C3H mice has been studied. The inhibition of tumors by cortisone was more striking in transplanted than in spontaneous tumors, as has been reported, but this could not be attributed to differences in growth rates. Some transplanted tumors in mice 10 months of age did not respond to cortisone treatment, in contrast to transplants in young mice. An important factor in determining the responsiveness of these tumors to cortisone is the age of the host. The level of nucleic acids and protein in tumors varied to the same extent in all groups. Marked variation characterized the in vivo incorporation of glycine-2-C14 and leucine-1-C14 into tumor protein and of adenine-8-C14 into nucleic acids, and no consistent biochemical differences could be demonstrated between spontaneous and transplanted tumors, with or without cortisone treatment, by the methods used in this study.
How to discriminate contamination from bloodstream infection due to coagulase-negative staphylococci: a prospective study with 654 patients
Authors: L. Elzi, B. Babouee, N. Vögeli, R. Laffer, M. Dangel, R. Frei, M. Battegay, A.F. Widmer
Journal: Clinical Microbiology and Infection (2012)
Abstract 3953: Enhanced radiation reponse in MCF-7 radioresistant cells by targeting Peroxiredoxin II
Authors: Tieli Wang, Anthony Joseph Diaz, Jian-Jian Li, Yun Yen, Daniel Tamae
Journal: Cancer Research (2014)

Abstract In our previous study, we identified a protein target, Peroxiredoxin II (PrxII) to be overexpressed in radioresistant MCF+FIR3 breast cancer cells and found that its expression and function is associated with breast cancer radiation sensitivity or resistance. Small interference RNA (siRNA) targeting the PrxII gene expression was able to sensitize MCF+FIR3 radioresistant breast cancer cells to ionizing radiation. The major focus of this work was to investigate how the radiation response of MCF+FIR3 radioresistant cells was affected by siRNA that inhibits PrxII gene expression. Our results presented here show that silencing PrxII gene expression increased cellular toxicity by altering cellular thiol status, inhibiting Ca2+ efflux from the cells and perturbing the intracellular Ca2+ homeostasis. By combining radiotherapy and siRNA technology, we hope to develop new therapeutic strategies that may have potential to enhance the efficacy of chemotherapeutic agents due to its targeted property to specific cancer related genes. Citation Format: Tieli Wang, Anthony Joseph Diaz, Jian-Jian Li, Yun Yen, Daniel Tamae. Enhanced radiation reponse in MCF-7 radioresistant cells by targeting Peroxiredoxin II. [abstract]. In: Proceedings of the 105th Annual Meeting of the American Association for Cancer Research; 2014 Apr 5-9; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2014;74(19 Suppl):Abstract nr 3953. doi:10.1158/1538-7445.AM2014-3953
Regional chest wall volume variations in heart failure patients during inspiratory muscle training
Authors: Daniella Brandao, Susan Lage, Jasiel Nascimento, Larissa Carvalho, Fabiana Vieira, Silvia Marinho Martins, Luciana Alcoforado, Raquel Britto, Veronica Parreira, Guilherme Fregonezi, Andrea Aliverti, Armele Dornelas de Andrade
Journal: European Respiratory Journal (2011)

It is unknown how heart failure (HF) and cardiomegaly associated with diaphragmatic weakness affects chest wall function. Therefore, we evaluated in these patients the distribution of volume variations into the different thoracoabdominal compartments during quiet breathing and during inspiratory muscle training. Thirty-one individuals were evaluated and divided into two groups: HF (17 patients with functional class II and III chronic heart failure associated with cardiomegaly) and control (12 healthy volunteers). All subjects were evaluated by spirometry, six-minute walking test (6MWT), and optoelectronic plethysmography (OEP) during threshold inspiratory muscle training (IMT). OEP allowed to assess right-left asymmetries in the volume changes of upper thoracic (Vrcp), lower thoracic (Vrca), and abdominal (Vab) compartments. While no significant differences were present between right and left sides in the control group during IMT, in HF patients volume variations of Vrca were 45.30%±9.10 and 54.33%±12.9, respectively in the left and right sides (p=0,03). This was associated to a significant decrease, compared to normals, of Vrca variations; in addition, a positive correlation between the%Vra,left and ejection fraction of left ventricle (r=0.468 and p=0.049), and a negative correlation between the Borg scale after the 6MWT and the%Vra, left side (r=-0.878 and p
In vitro interaction between pemetrexed and gemcitabine using different treatment schedules.
Authors: An Wouters, Bea Pauwels, Cindy Simoens, Hilde A J Lambrechts, Greet G O Pattyn, Jan B. Vermorken, Filip Lardon
Journal: Cancer Research (2006)

5441  The aim of this study is to evaluate the growth inhibitory effects of pemetrexed and gemcitabine against lung cancer cell lines in vitro and in vivo. Pemetrexed (ALIMTA®) is a novel antifolate antimetabolite with multiple enzymes targets. It inhibits thymidylate synthase (TS), leading to G1/S phase arrest and cell death. Gemcitabine (Gemzar®, dFdC) is a deoxycytidine analog. It inhibits DNA synthesis and blocks cells in G1/S phase boundary. In vitro growth inhibition was accessed with MTT assays. Results are summarized in the table. Overall gemcitabine is more potent than pemetrexed in both NSCLC and SCLC cell lines. SCLC is more sensitive than NSCLC to pemetrexed but more resistant to gemcitabine. In vivo efficacy was evaluated in athymic nude mice bearing H2122 NSCLC subcutaneous tumors. Seven days after implantation, mice were treated with vehicle, pemetrexed at 100, 200 and 300 mg/kg/day, ip injection for 10 doses, gemcitabine at 30, 60 and 120 mg/kg, ip injection, every 4 days for three doses. Relative to control, pemetrexed effectively delayed tumor growth by 12 to 18 days and gemcitabine delayed by 10 to 14 days respectively. Treatment with pemetrexed (100 mg/kg) and gemcitabine (30 mg/kg) concurrently delayed tumor growth by 12 days but with some toxic side effects. Sequential treatment with gemcitabine first followed by pemetrexed was detrimental and was not better than single agents alone, while sequential treatment with pemetrexed first then followed by gemcitabine was significantly better than single agent alone and delayed tumor growth by at least 14 days. In vivo efficacy was also evaluated in athymic nude rats with orthotopic H2122 NSCLC tumors. Ip injection of pemetrexed at 50, 100 and 200 mg/kg/day significantly prolonged rat survivals, but not in a dose-dependent manner. Low dose (50 mg/kg) of pemetrexed seemed to be more effective than high doses (100 or 200 mg/kg). Gemcitabine was toxic to nude rats due to poor deamination of gemcitabine in rats. In conclusions, we show that pemetrexed is more potent against SCLC than NSCLC cell lines while the reverse is true for gemcitabine. Our studies support sequential treatment with pemetrexed followed by gemcitabine produces synergistic growth delay in rodent models.
HAART Stopping News: Experts Examine Structured Therapy Interruption for HIV
Authors: M J Friedrich
Journal: JAMA (2000)

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