tbuckley/cabot-search huggingface dataset:
Abstract 14210: Standardized Protocol to Optimize Management of Patients with Post-operative Atrial Fibrillation Reduces Length of Stay and Hospital Costs
Authors: Brandon R Porten, Craig E Strauss, Ross F Garberich, Sharon K Wahl, Benjamin C Sun, Raed H Abdelhadi, Timothy D Henry
Journal: Circulation (2014)

BACKGROUND: Post-operative atrial fibrillation (POAF) develops in approximately 30-40% of patients undergoing cardiovascular (CV) surgery and increases major adverse events, length of stay (LOS) and hospitalization costs. A standardized protocol may optimize POAF management and decrease LOS, hospital costs and adverse events including post-operative stroke. METHODS: In March 2013, an AF inpatient protocol was implemented in our CV surgery center’s post-operative care units. The protocol incorporates a consensus driven decision support algorithm based on blood pressure, heart rate and duration of AF to guide beta-blocker, antiarrhythmic and anticoagulation therapy recommendations in real-time. Using a shared electronic medical record we reviewed all coronary artery bypass graft (CABG) and valve surgery cases from March 1, 2013 to April 30, 2014 and compared LOS, intensive care unit (ICU) duration and post-operative stroke in POAF patients with and without the protocol. Based on actual CV surgery volume and average total variable cost per hospital day, we estimated the protocol’s impact post-implementation and at 50% annual use. RESULTS: Among 492 CABG and valve surgery cases, 176 (35.8%) developed POAF. Among patients with POAF, 55 (31.3%) used the AF protocol and 121 (68.7%) did not. In patients with POAF, median LOS was significantly shorter in cases with the protocol (6.9 [6.0, 9.1] days vs. 8.2 [6.1, 11.9] days; p=0.016). There was no difference in ICU duration or post-operative stroke (Table). Among 151 annual cases of POAF, average total variable cost was $2,374 per hospital day. Post-implementation, 71.5 hospital days and $169,741 have been saved. Achieving 50% protocol use, we estimate 98.0 hospital days and $232,652 could be saved annually. CONCLUSIONS: A standardized decision support protocol for POAF patients is associated with shorter LOS and provides a significant reduction in hospital days and total variable cost.
410. Multivalent siRNAs for Combinatorial HIV Gene Therapy
Authors: Joseph S. Anderson, Akhil Banerjea, Ming-Jie Li, John Rossi, Ramesh Akkina
Journal: Molecular Therapy (2004)

Top of pageAbstract
Continual evolution of HIV-1 poses significant challenges for developing long-term effective gene therapy strategies. To overcome the propensity of the virus in developing resistance to individual anti-viral gene therapeutic constructs, it is necessary to target multiple stages of the viral life cycle that include viral entry, and pre- and post integration replication steps. Targeting viral co-receptors CXCR4 and CCR5 will help prevent viral entry, whereas interfering with the viral regulatory molecules rev and tat will inhibit intracellular replication events. SiRNAs that mediate RNA interference are attractive candidates for long range HIV gene therapy. However, a single siRNA is not expected to be effective for this purpose. In our present studies, we designed and tested siRNAs targeted to CXCR4, CCR5 and rev/tat both singly and in combination. SiRNA sequences were introduced downstream of U6 promoters for intracellular expression. Cells transfected with plasmids expressing the individual anti-coreceptor siRNAs showed down regulation of the cell surface proteins by as much as 78%. Additionally, SiRNA transfected cells were found to be highly resistant to HIV-1 challenge in vitro. Plasmids expressing three siRNA constructs against CXCR4, CCR5 and rev/tat arranged in tandem and driven by individual U6 promoters when transfected into cells also showed similar levels of coreceptor down regulation indicating that combinatorial constructs are effective. Although typical siRNAs are considered to be too short to induce interferon (IFN) responses, there is a concern that this possibility may still exist with some siRNAs based on recent reports. Therefore, we evaluated the possibility of IFN induction by both mono and combinatorial synthetic siRNA constructs. Forty-eight hours after siRNA transfection, levels of phosphorylated PKR, suggestive of IFN induction, were analyzed by Western blots. Poly IC, a potent IFN inducer was used as a positive control. Results have shown that none of our siRNA constructs induced IFN since the levels of phosphorylated PKR remained at basal levels similar to mock transfected cells. As these siRNAs seemed effective in down regulating their respective targets, they are promising candidates for introduction into lentiviral vectors for transduction into CD34 hematopoietic stem cells. Use of multivalent siRNAs is a potentially rewarding approach in controlling HIV-1 infection.
Host response to EBV infection in X-linked lymphoproliferative disease results from mutations in an SH2-domain encoding gene
Authors: Alison J. Coffey, Robert A. Brooksbank, Oliver Brandau, Toshitaka Oohashi, Gareth R. Howell, Jacqueline M. Bye, Anthony P. Cahn, Jillian Durham, Paul Heath, Paul Wray, Rebecca Pavitt, Jane Wilkinson, Margaret Leversha, Elizabeth Huckle, Charles J. Shaw-Smith, Andrew Dunham, Susan Rhodes, Volker Schuster, Giovanni Porta, Luo Yin, Paola Serafini, Bakary Sylla, Massimo Zollo, Brunella Franco, Alessandra Bolino, Marco Seri, Arpad Lanyi, Jack R. Davis, David Webster, Ann Harris, Gilbert Lenoir, Genevieve de St Basile, Alison Jones, Bernd H. Behloradsky, Helene Achatz, Jan Murken, Reinhard Fassler, Janos Sumegi, Giovanni Romeo, Mark Vaudin, Mark T. Ross, Alfons Meindl, David R. Bentley
Journal: Nature Genetics (1998)
Haploidentical Stem Cell Transplantation (HAPLO-HSCT) With Reduced Intensity Conditioning (RIC) Regimens and High Dose Cylophosphamide Post-Transplant (HD-CY) As Gvhd Prophylaxis In Patients With Relapsed Or Refractory Hodgkin´s Disease: Multicentric Spanish Experience
Authors: Jorge Gayoso, Pascual Balsalobre, Cristina Castilla-Llorente, María Jesús Pascual, Mi Kwon, David Serrano, Dolores Caballero, Jose Antonio Pérez-Simón, Arancha Bermudez, Carmen Martínez, Cristina Pascual, Inmaculada Heras, Carlos Solano, Angela Figuera, Antonia Sampol, Christelle Ferra, Pilar Herrera, Ismael Buno, Jose Luis Diez-Martin
Journal: Blood (2013)
14‐3‐3 in Thoracic Aortic Aneurysms: Identification of a Novel Autoantigen in Large Vessel Vasculitis
Authors: Ritu Chakravarti, Karishma Gupta, Mamuni Swain, Belinda Willard, Jaclyn Scholtz, Lars G. Svensson, Eric E. Roselli, Gosta Pettersson, Douglas R. Johnston, Edward G. Soltesz, Michifumi Yamashita, Dennis Stuehr, Thomas M. Daly, Gary S. Hoffman
Journal: Arthritis & Rheumatology (2015)

Large vessel vasculitides (LVV) are a group of autoimmune diseases characterized by injury to and anatomic modifications of large vessels, including the aorta and its branch vessels. Disease etiology is unknown. This study was undertaken to identify antigen targets within affected vessel walls in aortic root, ascending aorta, and aortic arch surgical specimens from patients with LVV, including giant cell arteritis, Takayasu arteritis, and isolated focal aortitis. Thoracic aortic aneurysm specimens and autologous blood were acquired from consenting patients who underwent aorta reconstruction procedures. Aorta proteins were extracted from both patients with LVV and age-, race-, and sex-matched disease controls with noninflammatory aneurysms. A total of 108 serum samples from patients with LVV, matched controls, and controls with antinuclear antibodies, different forms of vasculitis, or sepsis were tested. Evaluation of 108 serum samples and 22 aortic tissue specimens showed that 78% of patients with LVV produced antibodies to 14-3-3 proteins in the aortic wall (93.7% specificity), whereas controls were less likely to do so (6.7% produced antibodies). LVV patient sera contained autoantibody sufficient to immunoprecipitate 14-3-3 protein(s) from aortic lysates. Three of 7 isoforms of 14-3-3 were found to be up-regulated in aorta specimens from patients with LVV, and 2 isoforms (ε and ζ) were found to be antigenic in LVV. This is the first study to use sterile, snap-frozen thoracic aorta biopsy specimens to identify autoantigens in LVV. Our findings indicate that 78% of patients with LVV have antibody reactivity to 14-3-3 protein(s). The precise role of these antibodies and 14-3-3 proteins in LVV pathogenesis deserves further study.
The prevalence and 5-year incidence of ocular trauma
Authors: Tien Yin Wong, Barbara E.K Klein, Ronald Klein
Journal: Ophthalmology (2000)

Purpose To describe the cumulative lifetime prevalence and 5-year incidence of ocular trauma and their relation to risk factors in a defined white adult population living in a small town. Design Population-based cross-sectional and follow-up study. Participants Participants aged 43 to 86 years from the baseline Beaver Dam Eye Study that took place from 1988 through 1990 (n = 4926) and the follow-up study that took place from 1993 through 1995 (n = 3684). Methods Standardized interview at baseline and follow-up study. Main outcome measures Cumulative lifetime prevalence and 5-year incidence of self-reported history of ocular trauma. Results The cumulative lifetime prevalence and 5-year incidence of ocular trauma was 19.8% (n = 972) and 1.6% (n = 57), respectively. A history of trauma in both eyes was reported in 15% of the prevalent cases and 8% of the incident cases. Sharp objects caused more than half of all injuries. Persons aged 43 through 54 years were 2.5 times more likely to have a lifetime history of ocular trauma than persons aged 75 and older (odds ratios [OR], 2.57; 95% confidence interval [CI], 2.0, 3.29). Males had four times the prevalence of females (OR, 4.42; 95% CI, 3.79, 5.16). Almost one third of all males aged 43 through 54 years reported a history of ocular trauma in their lifetime. The higher risks in the 43 through 54 age group (OR, 1.60) and male gender (OR, 1.42) were not significant among incident cases. In multivariate analysis, blue collar (adjusted OR, 1.58; 95% CI, 1.32, 1.89) and farm-related workers (adjusted OR, 1.32; 95% CI, 0.93, 1.87) had higher lifetime risks of ocular trauma compared with white collar workers. People with a history of fractures also had increased lifetime risks (adjusted OR, 1.30; 95% CI, 1.13, 1.52). A history of ocular trauma reported in the baseline examination was significantly associated with a higher risk of ocular trauma occurring again in the next 5 years (adjusted OR, 3.27; 95% CI, 1.76, 5.82), especially if both eyes had previous trauma (adjusted OR, 5.15; 95% CI, 2.03, 13.0). Conclusions One fifth of white adult Americans more than 42 years of age residing in a small town reported ocular trauma in their lifetime. This group had a three times higher risk of experiencing ocular trauma again within 5 years.
The Old Man's Friend
Authors: W A Hensel
Journal: JAMA (2000)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Early Clinical Trial Results Following Administration of a Low Dose of a Novel Self Complementary Adeno-Associated Viral Vector Encoding Human Factor IX In Two Subjects with Severe Hemophilia B
Authors: Amit Nathwani, Edward Tuddenham, Cecilia Rosales, Jenny McIntosh, Anne Riddell, Pradip Rustagi, Bertil Glader, Mark Kay, James Allay, John Coleman, Susan Sleep, Katherine A. High, Federico Mingozzi, John T. Gray, Ulrike M. Reiss, Arthur W. Nienhuis, Andrew Davidoff
Journal: Blood (2010)
Climate change will affect UK health
Authors: Rhona MacDonald
Journal: BMJ (2001)

Climate changes over the next 50 years will have significant health effects in the United Kingdom, a report published last week by the Department of Health has said.

The report, which will assist the government in its long term planning, was compiled by a group of experts in meteorology and climate change, physiology, epidemiology, and microbiology. They reviewed the current evidence—in addition to using spatial analogues, predictive modelling, and their own judgment—to identify environmental factors that could affect the population's health. Changes in temperature and …
Abstract 15194: Arrhythmic Complications of Coronary Spasm Provocation Tests and Its Prognostic Impact in Patients with Vasospastic Angina -A Report from the Nationwide Multi-Center Registry by the Japanese Coronary Spasm Association-
Authors: Yusuke Takagi, Satoshi Yasuda, Ryusuke Tsunoda, Yasuhiro Ogata, Atsushi Seki, Tetsuya Sumiyoshi, Motoyuki Matsui, Toshikazu Goto, Yasuhiko Tanabe, Shozo Sueda, Toshiaki Sato, Satoshi Ogawa, Norifumi Kubo, Shin-ichi Momomura, Hisao Ogawa, Hiroaki Shimokawa
Journal: Circulation (2010)

Background: Coronary vasospasm provocation tests are useful for the diagnosis of vasospastic angina (VSA). However, these tests have a potential risk of arrhythmic complications including ventricul...
Melanoma and a Headache
Authors: Douglas B. Johnson, Tejaswi V. Mudigonda, Jeffrey A. Sosman
Journal: JAMA Oncology (2015)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Oncology HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Oncology journal
Abstract 3488: Electrocardiographic Differentiation of Negative T Waves of Acute Pulmonary Embolism from that of Acute Coronary Syndromes
Authors: Masami Kosuge, Kazuo Kimura, Toshiaki Ebina, Kiyoshi Hibi, Kengo Tsukahara, Jyun Okuda, Toshiyuki Ishikawa, Kazuaki Uchino, Satoshi Umemura
Journal: Circulation (2006)
10-minute consultation: Adverse drug event
Authors: N. Dunn
Journal: BMJ (2003)

A 72 year old woman on holiday in your area consults you four weeks after starting treatment with a non-steroidal anti-inflammatory drug (NSAID) for her painful knee. She complains of “a reaction” to the drug. She says she has had problems with similar drugs previously, but this drug is new and supposedly has fewer side effects. She says she has been feeling weak and giddy and has developed a widespread itchy skin rash. She tells you, however, that the drug was effective as a pain reliever. You find that she also has angina and high blood pressure. #### Reporting adverse events in the United Kingdom
Abstract 10: Increased Consumption of Fruits and Vegetables and Weight Change Over Time
Authors: Monica L Bertoia, Kenneth J Mukamal, Leah E Cahill, Tao Hou, David S Ludwig, Dariush Mozaffarian, Walter C Willett, Frank B Hu, Eric B Rimm
Journal: Circulation (2014)

Introduction: Current dietary guidelines recommend eating a variety of fruits and vegetables. However, based on nutrient composition, specific fruits and vegetables may be more or less beneficial for weight maintenance. Hypothesis: Fruits and vegetables with a higher fiber content or lower glycemic load are more strongly associated with weight maintenance and even weight loss, in part through mechanisms related to increased satiety. Methods: We examined the association between increased consumption of fruits and vegetables and change in body weight among participants &lt;65 years of age from three large prospective cohort studies: 41,608 women in the Nurses’ Health Study (NHS) I, 20,143 men in the Health Professionals Follow-up Study, and 67,533 women in the NHS II. Beginning in 1986, these associations were examined during 24 years of follow-up within 4-year time intervals, adjusting for simultaneous changes in other lifestyle factors such as diet, smoking, and physical activity. Results: Increased consumption of one serving per day of several types of fruits was inversely associated with weight gain over 4 years, for example -1.11 lbs (95% CI, -1.43 to -0.80 lbs) for berries and -0.96 lbs (95% CI, -1.20 to -0.72 lbs) for apples/pears. Increased consumption of several vegetables was also inversely associated with weight gain, for example -2.15 lbs (95% CI, -2.58 to -1.73 lbs) for tofu/soy and -1.18 lbs (95% CI, -1.73 to -0.64 lbs) for cauliflower. On the other hand, increased consumption of some vegetables was positively associated with weight change, for example corn (1.69 lbs; 95% CI, 0.90 to 2.48 lbs) and peas (0.81 lbs; 95% CI 0.16 to 1.46 lbs). The magnitude of weight change associated with increased consumption of high fiber vegetables (-0.37 lbs; 95% CI -0.48 to -0.27 lbs) was larger than that for low fiber vegetables (-0.13 lbs; 95% CI -0.23 to -0.02 lbs). Increased consumption of low glycemic load vegetables was associated with a greater magnitude of weight change, -0.37 lbs (95% CI, -0.63 to -0.11 lbs), compared to high glycemic load vegetables, -0.01 lbs (95% CI, -0.14 to 0.11 lbs). In contrast, weight change associated with fruit consumption did not vary by fiber content or glycemic load. Conclusions: Increased consumption of total fruits and vegetables was inversely associated with weight change over 4 years, however we found wide-ranging associations for specific foods, partly due to the fiber content and glycemic load of vegetables but not fruits.
The impact of food hypersensitivity reported in 9‐year‐old children by their parents on health‐related quality of life
Authors: E. Östblom, A.‐C. Egmar, A. Gardulf, G. Lilja, M. Wickman
Journal: Allergy (2008)

Background: There are only a few studies on the impact of food hypersensitivity (FHS) in children on health‐related quality of life (HRQL). The present study was designed to examine this impact in a population‐based birth cohort (BAMSE). Methods: A nested case–control study was performed within the cohort. The parents of 1378 nine‐year‐old children filled out a generic questionnaire with 13 subscales (Child Health Questionnaire Parental Form 28 – CHQ‐PF28) supplemented with disease‐specific questions concerning FHS. There were 212 children with report of FHS. Another 221 children with allergic diseases but not FHS were examined for comparison. Furthermore, the impact of pronounced symptoms of FHS and of increasing levels of food‐specific IgE antibodies on HRQL was also analysed. Results: The children with FHS exhibited significantly lower scores on the subscales physical functioning, role/social limitations – physical and general health in the generic instrument. Furthermore, children with food‐related symptoms from the lower airways were scored lower on Self Esteem, Parental Impact – time and Family Cohesion. Sensitization per se did not alter these patterns, but high levels of food‐specific IgE‐antibodies affected mental health and general health negatively. A physician’s diagnosis of food allergy did not affect any of the subscales negatively. Conclusions: Parents reported that FHS exerts a negative impact on the HRQL of 9‐year‐old children, in particular in children with symptoms from the lower airways or if the FHS is associated with high levels of food‐specific IgE‐antibodies. Healthcare‐givers must put major effort into improving and maintaining the HRQL of these children.
FEVER THERAPY IN THE TREATMENT OF ACUTE RHEUMATIC FEVER
Authors: F. Lowell Dunn, E. E. Simmons
Journal: Annals of Internal Medicine (1938)

Article1 March 1938FEVER THERAPY IN THE TREATMENT OF ACUTE RHEUMATIC FEVERF. LOWELL DUNN, M.D., F.A.C.P., E. E. SIMMONS, M.D.F. LOWELL DUNN, M.D., F.A.C.P.Search for more papers by this author, E. E. SIMMONS, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-11-9-1600 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptAt the Fever Therapy Department of the University of Nebraska 172 arthritis patients have received treatments with the Kettering hypertherm cabinet.† Of these 12 were diagnosed as acute rheumatic fever. This small group, together with three cases from the University of Colorado, furnish the material for this report.‡The table gives a summary of the cases, eight of which are described in somewhat greater detail in the text. Since our primary interest was the effect of fever therapy upon the course of rheumatic fever we have excluded the frequent borderline cases in which there is often clinical disagreement as to...Bibliography1. BARNACLEEWALTEBAUGH CHJRFG: Artificial fever treatment of chorea, Jr. Am. Med. Assoc., 1936, cvi, 2046-2048. CrossrefGoogle Scholar2. SUTTONDODGE LFKG: Fever therapy in chorea and in rheumatic carditis with and without chorea, Jr. Lab. and Clin. Med., 1936, xxi, 619-629. Google Scholar3. BARNACLEEWALTEBAUGH CHJRFG: Personal communication to authors. Google Scholar4. BLANDJONES EFTD: Clinical observations on the events preceding the appearance of rheumatic fever, Jr. Clin. Invest., 1933, xiv, 633-648. Google Scholar5. ROTHSCHILDKUGELGROSS MAMAL: Incidence and significance of active infection in cases of rheumatic cardiovalvular disease during various age periods; clinical and pathological study, Am. Heart Jr., 1934, ix, 586-595. CrossrefGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Omaha, Nebraska*Received for publication May 3, 1937.From the University of Nebraska Fever Therapy Department, Bishop Clarkson Memorial Hospital, Omaha, Nebraska; A. E. Bennett, M.D., Director.†We are indebted to Dr. Charles F. Kettering, Director of General Motors Research Department, and Dr. Walter M. Simpson, Director of the Kettering Institute for Medical Research, Miami Valley Hospital, Dayton, Ohio, for the loan of the Kettering hypertherms used in our studies.‡We are indebted to Dr. F. Ebaugh, Dr. Clarke H. Barnacle, and Dr. Jack R. Ewalt for the privilege of including the three cases from the Fever Therapy Department of the University of Colorado. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 March 1938Volume 11, Issue 9Page: 1600-1606KeywordsHyperthermiaPatientsRheumatic fever ePublished: 1 December 2008 Issue Published: 1 March 1938 PDF downloadLoading ...