UNUSUAL REMISSION IN A CASE OF THROMBOTIC THROMBOCYTOPENIC PURPURA SYNDROME FOLLOWING FRESH BLOOD EXCHANGE TRANSFUSIONS
Authors: M A RUBINSTEIN, B M KAGAN, M H MACGILLVIRAY, R MERLISS, H SACKS
Journal: Annals of Internal Medicine (1959)

Case Reports1 December 1959UNUSUAL REMISSION IN A CASE OF THROMBOTIC THROMBOCYTOPENIC PURPURA SYNDROME FOLLOWING FRESH BLOOD EXCHANGE TRANSFUSIONSMICHAEL A. RUBINSTEIN, M.D., F.A.C.P., BENJAMIN M. KAGAN, M.D., F.A.C.P., MARGARET H. MACGILLVIRAY, M.D., REUBEN MERLISS, M.D., F.A.C.P., HARRY SACKS, M.D.MICHAEL A. RUBINSTEIN, M.D., F.A.C.P., BENJAMIN M. KAGAN, M.D., F.A.C.P., MARGARET H. MACGILLVIRAY, M.D., REUBEN MERLISS, M.D., F.A.C.P., HARRY SACKS, M.D.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-51-6-1409 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptEver since its original description by Moschcowitz in 19251 as "an acute febrile pleiochromic anemia with hyaline thrombosis of the terminal arterioles and capillaries" associated with a bleeding tendency, thrombotic thrombocytopenic purpura (TTP) has been reported with increasing frequency, especially in the last decade.2, 3, 4 With 78 cases reported in the available literature, and more known not to have been recorded, the disease is no longer considered to be unusually rare.The anemia has been shown to be hemolytic, and the hemorrhagic tendency to be due to thrombocytopenia. However, the nature of the characteristic vascular thrombi has not been...Bibliography1. Moschcowitz E: An acute febrile pleiochromic anemia with hyaline thrombosis of the terminal arterioles and capillaries, Arch. Int. Med. 36: 89, 1925. CrossrefGoogle Scholar2. Barondess JA: Thrombotic thrombocytopenic purpura, Am. J. Med. 13: 294, 1952. CrossrefMedlineGoogle Scholar3. Singer K: Thrombotic thrombocytopenic purpura, Advances Int. Med. 6: 195, 1954. MedlineGoogle Scholar4. Antes EH: Thrombotic thrombocytopenic purpura: a review of the literature, Ann. Int. Med. 48: 512, 1958. LinkGoogle Scholar5. BaehrKlempererSchiffrin GPA: An acute febrile anemia and thrombocytopenic purpura with diffuse thromboses of capillaries and arterioles, Tr. A. Am. Physicians 51: 43, 1936. Google Scholar6. Gore I: Disseminated arteriolar and capillary platelet thrombosis, Am. J. Path. 26: 155, 1950. MedlineGoogle Scholar7. Orbison JL: Morphology of thrombotic thrombocytopenic purpura with demonstration of aneurysms, Am. J. Path. 28: 129, 1952. MedlineGoogle Scholar8. SingerMotulskyShanberge KAGJN: Thrombotic thrombocytopenic purpura: studies on the hemolytic syndrome of the disease, Blood 5: 434, 1950. CrossrefMedlineGoogle Scholar9. AdelsonHeitzmanFennessey EEJJF: Thrombohemolytic thrombocytopenic purpura, Arch. Int. Med. 94: 42, 1954. CrossrefGoogle Scholar10. StefaniniDameshek MW: The hemorrhagic disorders, 1955, Grune & Stratton, New York. Google Scholar11. CooperStickneyPeaseBennett TJMGLWA: Thrombotic thrombocytopenic purpura. Confirmation of clinical diagnosis by bone marrow aspiration, Am. J. Med. 13: 374, 1952. CrossrefMedlineGoogle Scholar12. LaszloAlvarezFeldman MHAF: The association of thrombotic thrombocytopenic purpura and disseminated lupus erythematosus; report of case, Ann. Int. Med. 42: 1306, 1955. Google Scholar13. Beigelman PM: Variants of the platelet thrombosis syndrome and their relationship to disseminated lupus, Arch. Path. 51: 213, 1951. Google Scholar14. MeachamOrbisonHeinleSteeleSchaefer ACJLRWHJJA: Thrombotic thrombocytopenic purpura, Blood 6: 796, 1951. CrossrefGoogle Scholar15. EvansDuane RSRT: Acquired hemolytic anemia, Blood 4: 1196-1213, 1949. CrossrefMedlineGoogle Scholar16. EvansTakahashiDuanePayneLiu RSKRTRGK: Primary thrombocytopenic purpura and acquired hemolytic anemia, Arch. Int. Med. 87: 48, 1951. CrossrefGoogle Scholar17. ShumwayMiller CNG: An unusual syndrome of hemolytic anemia, thrombocytopenic purpura and renal disease, Blood 12: 1045, 1957. CrossrefMedlineGoogle Scholar18. GardnerMcElfreshHarrisDiamond FHAEJWLK: The effect of adrenocorticotropic hormone (ACTH) in idiopathic acquired hemolytic anemia as related to the hemolytic mechanisms, J. Lab. and Clin. Med. 37: 444, 1951. MedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Beverly Hills, California*Received for publication April 27, 1959.From the Divisions of Medicine (Hematology), Pediatrics and Laboratories, Cedars of Lebanon Hospital, Los Angeles, California.Requests for reprints should be addressed to Michael A. Rubinstein, M.D., Cedars of Lebanon Hospital, 4833 Fountain Avenue, Los Angeles, California. 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