tbuckley/cabot-search huggingface dataset:
β2 integrin–derived signals induce cell survival and proliferation of AML blasts by activating a Syk/STAT signaling axis
Authors: Thomas Oellerich, Mark F. Oellerich, Michael Engelke, Silvia Münch, Sebastian Mohr, Marika Nimz, He-Hsuan Hsiao, Jasmin Corso, Jing Zhang, Hanibal Bohnenberger, Tobias Berg, Michael A. Rieger, Jürgen Wienands, Gesine Bug, Christian Brandts, Henning Urlaub, Hubert Serve
Journal: Blood (2013)
Lipoprotein (a) Levels in African-Americans with NIDDM
Authors: W Douglas Scheer, Donald A Boudreau, Curtiss B Cook
Journal: Diabetes Care (1996)

OBJECTIVE The purpose of this study was to investigate possible relationships between lipoprotein (a) [Lp(a)] levels and NIDDM in African-Americans. The objectives were to identify associations between Lp(a) levels of subjects with and without NIDDM and to determine the influence of glycemic control, determined by GHb, and of mode of therapy on Lp(a) levels. RESEARCH DESIGN AND METHODS We studied 141 African-American subjects, 103 with NIDDM and 38 without NIDDM. Their Lp(a) levels, GHb levels, and apolipoprotein (a) [apo(a)] isoforms were determined. Clinical information, including mode of therapy (sulfonylurea, insulin, or no pharmacological therapy), date of diagnosis, and medical history, was obtained by chart review and patient interview. RESULTS There was no significant difference in median Lp(a) levels between the non-NIDDM (25.5 mg/dl) and NIDDM (24.0 mg/dl) study subjects. No statistically significant difference was found in Lp(a) levels when NIDDM patients with GHb &amp;lt; 12.3% were compared to those with GHb ≥ 12.3% (P = 0.096). An inverse relationship was found between apo(a) root-mean-square isoform size and Lp(a) level (r2 = 0.091, P = 0.0035). Analysis of the cases by mode of therapy indicates that there is evidence of an increased median level of Lp(a) in African-Americans with NIDDM on insulin therapy relative to those on sulfonylurea (34.0 vs. 16.0 mg/dl; P = 0.013) and to nondiabetic subjects (34.0 vs. 25.5 mg/dl; P = 0.043). CONCLUSIONS We conclude that the level of plasma Lp(a) is higher in African-Americans with NIDDM who are being treated with insulin when compared to those on sulfonylurea therapy and to those who are non-NIDDM subjects, and this does not seem to be due to genetic variance or method bias.
Cutaneous T-Cell Lymphomas
Authors: T. ESTRACH
Journal: Annals of Internal Medicine (1981)

Letters and Corrections1 March 1981Cutaneous T-Cell LymphomasT. ESTRACH, M.D., M. LECHA, M.D., J.M. MASCARO, M.D., E. MONTSERRAT, M.D., C. ROZMAN, M.D.T. ESTRACH, M.D.Search for more papers by this author, M. LECHA, M.D.Search for more papers by this author, J.M. MASCARO, M.D.Search for more papers by this author, E. MONTSERRAT, M.D.Search for more papers by this author, C. ROZMAN, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-94-3-413_1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: We agree with the methods and results reported in the paper "Prospective Staging of Patients with Cutaneous T-Cell Lymphomas" (1). We have been working on this subject and have accepted the TNM (tumor, node, metastasis) classification of the American Joint Committee on Cancer Staging (2). Since January 1980, we have studied 13 patients with cutaneous T-cell lymphoma (ESTRACH T, LECHA M, MASCARO JM. Department of Dermatology. MONTSERRAT E, ROZMAN C. Department of Haematology. Faculty of Medicine. Barcelona, Spain. Unpublished observations). All these patients have been studied with the same staging procedures (lymphangiogram, liver biopsy, bone marrow biopsy)...References1. BUNNHUBERMANWHANG-PENG PMJ. Prospective staging of patients with cutaneous T-cell lymphomas: demonstration of a high frequency of extracutaneous dissemination. Ann Intern Med. 1980;93:223-30. LinkGoogle Scholar2. BUNNLAMBERG PS. Report of the Committee on Studying and Classification of Cutaneous T-Cell Lymphomas. Cancer Treaty Rep. 1979;63:725-8. MedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Hospital Clinico y Provincial de Barcelona Barcelona, Spain PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 March 1981Volume 94, Issue 3Page: 413-413KeywordsBiopsyBone marrowDermatologyHematology and oncologyLiverLymphomaTumor node metastasis Issue Published: 1 March 1981 PDF DownloadLoading ...
Implications of inflammatory changes on cervical cytology: Authors' reply
Authors: J D Wilson, A J Robinson
Journal: BMJ (1990)

leucocytes, in addition, does not automatically imply inflammation.As is known, these non- discrete criteria lend themselves to extensive interobserver variation in reporting.The statement that the study population was selected solely by returned cytology forms implies that no single observer reported the results of all of the tests.Indeed, the results were probably reported by many observers of varying ability and experience.It would have been prudent to have had a single cvtopathologist to review all of the preparations in this study.Furthermore, the fact that some slides were unsatisfactory shows that the selection was flawed.It is worth noting that many of the infections discussed may be identified from cytological preparations: Candida albicans, Gardnerella vaginalis, Trichomonas vaginalis, and herpes simplex virus.If identified these may be listed as
Predictors of Employment Status After Cardiac Surgery
Authors: Babette A. Stanton
Journal: JAMA (1983)

Preoperative predictors of postoperative employment status were studied in 228 patients (aged 25 to 64 years) who underwent cardiac surgery. Of the 150 patients working in the year before surgery, 73% returned within six months. Of those not so employed, 18% started working. Patients who expected preoperatively to return to work did so at an 82% rate compared with 39% of the others. This was a strong predictor in the multiple regression analysis. Educational level and family income were stronger predictors than occupation or level of physical exertion required. Rates of return were higher in patients with less severe angina and less fatigue preoperatively, but did not differ significantly by sex, surgical procedure, or duration of illness. Seven variables predicted work status correctly for 86% of persons. These results suggest that determinants of return to work are largely present before surgery and that patients' attitudes and expectations play an important role.
DENDRITIC CIRCUITS: THE PROPERTIES OF CORTICAL PATHS INVOLVING DENDRITES
Authors: M. H. CLARE, GEORGE H. BISHOP
Journal: American Journal of Psychiatry (1955)

The interaction between areas of the cerebral cortex of the cat have been studied by recording the electrical responses of one area following stimulation of another area by single and repetitive shocks. The cortex is stimulated at different depths, and records are taken from one electrode at the cortical surface and another in white matter, or from fractional leads, in the area responding. Axons from the stimulated point of one region may end in the second region by synaptic connections either on cell bodies or on cell dendrites. The paths ending on the apical dendrites of pyramidal cells are particularly dealt with here. The type of ending can be recognized by the form of the activity set up in the neurones responding. If axonal endings on cell bodies are involved, the sequence of events starts with one or more brief spikes (1 msec. in duration) characteristic of all-or-none activity in cell bodies and their axons. If the paths activated end on dendrites, a slower wave (15 msec. in duration) is the initial and may be the only response. Certain conclusions can be drawn from the experimental results. The properties of cell dendrities are different from those of cell bodies and their axons. The duration of response of dendrites is much longer; they have no true absolutely refractory period; they may support local activity at a stimulated region without propagation of impulses to their cell bodies, and then affect their cell bodies by altering the excitability of the latter to impulses reaching them directly. They can be maintained in persistent negativity by repetitive stimulation. Of relations so far studied, the afferent projection areas are activated chiefly by means of axonal paths ending on cell bodies, while many of the interconnections from cortex to cortex are made by axonal paths ending on dendrites.
Haemorrhagic Gangrene of the Skin in Chronic Lymphatic Leukaemia
Authors: I. Sarkany, R. M. Ransom
Journal: BMJ (1955)

Xof terminating the pregnancy.A rise of blood pressure in the last few weeks of pregnancy or during labour should be viewed seriously and caesarean section undertaken. Summary and ConclusionsThere are records of only 91 patients in whom coarctation of the aorta was associated with pregnancy.Five further cases are reported.The association carries with it serious risks, especi- ally of rupture of the aorta, but, in spite of these, many women have not been adversely affected by multiple pregnancies and have lived to an age well beyond the average expectation of life in coarctation of the aorta.Earlier diagnosis and surgical treatment of the coarcta- tion offer means of improving the prognosis.Diagnosis is not difficult, and depends mainly on the awareness of the examiner and routine palpation of the femoral pulses in all patients with hypertension.The antenatal clinic offers unusual opportunities for early diagnosis.General principles in management of these patients are described and the importance of individual assess- ment and surgical treatment for the coarctation is stressed.I thank Mr. J. M. McKiddie, who kindly allowed me to quote Cases 2 and 3; the late Mr. B. L.
Randomized Selection Design Trial Evaluating CD8<sup>+</sup>-Enriched Versus Unselected Tumor-Infiltrating Lymphocytes for Adoptive Cell Therapy for Patients With Melanoma
Authors: Mark E. Dudley, Colin A. Gross, Robert P.T. Somerville, Young Hong, Nicholas P. Schaub, Shannon F. Rosati, Donald E. White, Debbie Nathan, Nicholas P. Restifo, Seth M. Steinberg, John R. Wunderlich, Udai S. Kammula, Richard M. Sherry, James C. Yang, Giao Q. Phan, Marybeth S. Hughes, Carolyn M. Laurencot, Steven A. Rosenberg
Journal: Journal of Clinical Oncology (2013)

Adoptive cell therapy (ACT) with autologous tumor-infiltrating lymphocytes (TILs) and high-dose interleukin-2 (IL-2) administered to lymphodepleted patients with melanoma can cause durable tumor regressions. The optimal TIL product for ACT is unknown.Patients with metastatic melanoma were prospectively assigned to receive unselected young TILs versus CD8(+)-enriched TILs. All patients received lymphodepleting chemotherapy and high-dose IL-2 therapy and were assessed for response, toxicity, survival, and immunologic end points.Thirty-four patients received unselected young TILs with a median of 8.0% CD4(+) lymphocytes, and 35 patients received CD8(+)-enriched TILs with a median of 0.3% CD4(+) lymphocytes. One month after TIL infusion, patients who received CD8(+)-enriched TILs had significantly fewer CD4(+) peripheral blood lymphocytes (P = .01). Twelve patients responded to therapy with unselected young TILs (according to Response Evaluation Criteria in Solid Tumors [RECIST]), and seven patients responded to CD8(+)-enriched TILs (35% v 20%; not significant). Retrospective studies showed a significant association between response to treatment and interferon gamma secretion by the infused TILs in response to autologous tumor (P = .04), and in the subgroup of patients who received TILs from subcutaneous tumors, eight of 15 patients receiving unselected young TILs responded but none of eight patients receiving CD8(+)-enriched TILs responded.A randomized selection design trial was feasible for improving individualized TIL therapy. Since the evidence indicates that CD8(+)-enriched TILs are not more potent therapeutically and they are more laborious to prepare, future studies should focus on unselected young TILs.
Pulmonary Function in Alveolar Proteinosis. Detailed Function Studies in Nine Patients.
Authors: Milton S. Braunstein
Journal: Annals of Internal Medicine (1972)

Meeting Abstracts1 May 1972Pulmonary Function in Alveolar Proteinosis. Detailed Function Studies in Nine Patients.Milton S. Braunstein, M.D., Robert M. Rogers, M.D., F.A.C.P., John F. Shuman, M.D.Milton S. Braunstein, M.D.Search for more papers by this author, Robert M. Rogers, M.D., F.A.C.P.Search for more papers by this author, John F. Shuman, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-76-5-879_1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptNumerous case reports and reviews of pulmonary alveolar proteinosis have appeared since the original description of the disease in 1958. Pulmonary function studies, however, have been reported primarily as incomplete, incidental data. Detailed pulmonary function studies were performed 14 times on nine patients with alveolar proteinosis before treatment or during recrudescence of symptoms. Spirometry and arterial blood gases were measured using standard techniques. Functional residual capacity (FRC) and airway resistance (RA) were determined in a DuBois constant-volume variable pressure body Plethysmograph, and diffusing capacity (DLCO) was determined by the single-breath technique. Static expiratory lung compliance was obtained from the slope... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Philadelphia, Pa. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 May 1972Volume 76, Issue 5Page: 879-879KeywordsBloodLungsProteinsPulmonary diseasesPulmonary functionRisk managementSpirometry Issue Published: 1 May 1972 PDF downloadLoading ...
446 ACUTE EXACERBATION OF CHRONIC HEPATITIS C: CLINICAL PRESENTATION, OUTCOME AND RESPONSE TO ANTI-HCV TREATMENT
Authors: N. Coppola, M. Pisaturo, M. Stanzione, V. Messina, C. Sagnelli, L. Alessio, M. Starace, G. Pasquale, E. Sagnelli
Journal: Journal of Hepatology (2013)
WHO agrees plan to speed up research on risk to human health from climate change
Authors: J. Zarocostas
Journal: BMJ (2008)

The World Health Organization has agreed to a plan to speed up research to help governments formulate policies to counter the risks posed by climate change to human health.

At present scientific research papers about the links between climate change and health are outnumbered by papers about air pollution by almost eight times, the agency said, at the end of a meeting in Madrid attended by more than 80 leading experts on climate change and health.

“Member states asked WHO to help them strengthen the evidence base for policy action. This plan provides the framework for doing that. It sets out guidance for governments, research institutions, and donors looking to fill crucial knowledge gaps,” said Margaret Chan, WHO’s director general.

Maria Neira, the WHO director for public health and environment, told reporters that the agency would …
TCT-845 Femoral Approach with Systematic Use of FemoSeal™ Closure Device Compared to Radial Approach in Primary Angioplasty: a Propensity-matched Comparison
Authors: Stefano Rigattieri, Alessandro Alonzo, Francesca Giovannelli, Cristian Di Russo, Alessandro Sciahbasi, Andrea Berni
Journal: Journal of the American College of Cardiology (2014)
Presence of Left-to-Right Atrial Frequency Gradient in Paroxysmal but Not Persistent Atrial Fibrillation in Humans
Authors: Sorin Lazar, Sanjay Dixit, Francis E. Marchlinski, David J. Callans, Edward P. Gerstenfeld
Journal: Circulation (2004)

Recent studies have demonstrated spatiotemporal organization in atrial fibrillation (AF), with a left-to-right atrial frequency gradient during AF in isolated sheep hearts. We hypothesized that human AF would also manifest a left-to-right atrial frequency gradient.Thirty-one patients aged 56.7+/-10.5 years with a history of paroxysmal or persistent (>1 month) AF were included. Recordings were made at each pulmonary vein (PV) ostium and simultaneously from the coronary sinus (CS) and posterior right atrium (RA) during AF. Sequential fast Fourier transforms (FFTs) were performed. FFT profiles were analyzed to determine the dominant frequency (DF). There were 18 patients with paroxysmal AF and 13 with persistent AF. In the paroxysmal group, there was a significant left-to-right atrial DF gradient, with DF highest at the PV/left atrial (LA) junction, intermediate at the CS, and lowest in the RA (6.2+/-0.8, 5.5+/-0.7, and 5.1+/-0.6 Hz, respectively; P<0.001). There were no patients in whom DF was greater at the RA than the PV/LA junction. In the persistent group, there was no significant difference between DF recorded from the LA/PV junction, CS, and RA (6.1+/-0.7, 5.8+/-0.6, and 5.8+/-0.6 Hz, respectively; P=NS).In humans with paroxysmal AF, DFs are highest at the PV/LA junction, intermediate in the CS, and slowest in the posterior RA. These findings agree with animal models that suggest that the posterior LA may play an important role in maintaining paroxysmal AF. The role of the posterior LA in persistent AF requires further study.
Prevalence of occult HBV in HIV/HCV coinfected patients in a large, multinational trial (APRICOT)
Authors: M. Rodriguez-Torres, J. Gonzalez-Garcia, M. Mendes-Correa, C. Katlama, M. Nelson, D. Cooper, S. Staszewski, G. Carosi, F. Smaill, N. Brau, F.J. Torriani
Journal: Journal of Hepatology (2003)
Low Blood Flow Estimates in Lower-Leg Arteries Predict Cardiovascular Events in Japanese Patients With Type 2 Diabetes With Normal Ankle-Brachial Indexes
Authors: Toru Yoshimura, Eiji Suzuki, Katsuya Egawa, Yoshihiko Nishio, Hiroshi Maegawa, Shigehiro Morikawa, Toshiro Inubushi, Akitaka Hisatomi, Kazuma Fujimoto, Atsunori Kashiwagi
Journal: Diabetes Care (2006)

To examine the association of baseline measures in lower-leg arteries and conventional cardiovascular risk factors with the incidence of cardiovascular disease (CVD) events in type 2 diabetic patients with normal ankle-brachial indexes (ABIs) (>0.9).We studied 129 type 2 diabetic patients and 35 age-matched nondiabetic subjects with no apparent CVD consecutively admitted to our hospital. At baseline, total flow volume and resistive index, as an index of vascular resistance, at the popliteal artery was evaluated using gated two-dimensional cine-mode phase-contrast magnetic resonance imaging. Patients were followed 4.8 +/- 1.5 years (range 3.0-8.2) or until their first event of CVD.On follow-up, 16 patients developed primary CVD events. Patients with CVD had lower blood flow (P < 0.01) and higher vascular resistance (P < 0.05) than patients without CVD. When the patients were grouped into tertiles according to their levels of total flow volume (129.6-85.5, 85.3-63.3, and 62.7-23.8 ml/min), Kaplan-Meier analysis showed a higher probability of developing CVD events in patients in the lowest than in patients in the highest (P = 0.0199, log-rank test) tertile. Multivariate Cox proportional hazards analysis revealed that the lowest tertile for flow volume (hazard ratio [HR] 8.60, 95% CI 1.61-45.97, P = 0.012), hypertension (3.99, 1.12-14.25, P = 0.033), and smoking status (12.01, 1.21-119.28, P = 0.034) were significant independent predictors of CVD events.We have demonstrated that low blood flow estimates in lower-leg arteries may be predictive for CVD events among Japanese patients with type 2 diabetes even though they have a normal ABI.
Systems-level analysis of age-related macular degeneration reveals global biomarkers and phenotype-specific functional networks
Authors: Aaron M Newman, Natasha B Gallo, Lisa S Hancox, Norma J Miller, Carolyn M Radeke, Michelle A Maloney, James B Cooper, Gregory S Hageman, Don H Anderson, Lincoln V Johnson, Monte J Radeke
Journal: Genome Medicine (2012)

Abstract Background Age-related macular degeneration (AMD) is a leading cause of blindness that affects the central region of the retinal pigmented epithelium (RPE), choroid, and neural retina. Initially characterized by an accumulation of sub-RPE deposits, AMD leads to progressive retinal degeneration, and in advanced cases, irreversible vision loss. Although genetic analysis, animal models, and cell culture systems have yielded important insights into AMD, the molecular pathways underlying AMD's onset and progression remain poorly delineated. We sought to better understand the molecular underpinnings of this devastating disease by performing the first comparative transcriptome analysis of AMD and normal human donor eyes. Methods RPE-choroid and retina tissue samples were obtained from a common cohort of 31 normal, 26 AMD, and 11 potential pre-AMD human donor eyes. Transcriptome profiles were generated for macular and extramacular regions, and statistical and bioinformatic methods were employed to identify disease-associated gene signatures and functionally enriched protein association networks. Selected genes of high significance were validated using an independent donor cohort. Results We identified over 50 annotated genes enriched in cell-mediated immune responses that are globally over-expressed in RPE-choroid AMD phenotypes. Using a machine learning model and a second donor cohort, we show that the top 20 global genes are predictive of AMD clinical diagnosis. We also discovered functionally enriched gene sets in the RPE-choroid that delineate the advanced AMD phenotypes, neovascular AMD and geographic atrophy. Moreover, we identified a graded increase of transcript levels in the retina related to wound response, complement cascade, and neurogenesis that strongly correlates with decreased levels of phototransduction transcripts and increased AMD severity. Based on our findings, we assembled protein-protein interactomes that highlight functional networks likely to be involved in AMD pathogenesis. Conclusions We discovered new global biomarkers and gene expression signatures of AMD. These results are consistent with a model whereby cell-based inflammatory responses represent a central feature of AMD etiology, and depending on genetics, environment, or stochastic factors, may give rise to the advanced AMD phenotypes characterized by angiogenesis and/or cell death. Genes regulating these immunological activities, along with numerous other genes identified here, represent promising new targets for AMD-directed therapeutics and diagnostics. Please see related commentary: http://www.biomedcentral.com/1741-7015/10/21/abstract