tbuckley/cabot-search huggingface dataset:
Successful Removal of an Entire Lung for Carcinoma of the Bronchus
Authors: Evarts A. Graham
Journal: JAMA (1984)

Carcinoma of the bronchus in recent years has become a problem of major importance. It is now known that primary carcinoma of the lung, which almost always arises in a bronchus, constitutes between 5 and 10 per cent of all carcinomas.<sup>1</sup>In frequency, therefore, it is comparable with carcinoma of the large intestine, and it is much more frequent than the malignant tumors of some other organs that have received much more comment. The problem of primary carcinoma of the lung is of special importance, since up to the present time at least the prognosis has been almost uniformly bad because of the complete futility of any methods of treatment other than surgical excision. There is no record in the literature of the successful treatment by radiotherapy of a single case in which the pathologic evidence has been incontrovertible and in which a five year interval without recurrence has
OVARIOTOMY FOR UNUSUALLY LARGE OVARIAN CYST IN A WOMAN OF 73: RECOVERY
Authors: W. Everett
Journal: BMJ (1929)

immininent.In two eases blood transfusion had to be resorted to in order tlhat the patients might be kept alive during hle -operationi of suprapubic cystotomy.Thie bladder haemorrhage was conitrolled witiliii a few lhours of the oniset of il{e riadium exposure.It is niecessary to stress the point that all the twenty-three patients, before treatment was commenced, wvero profoundly ill from either sepsis or profuse h1aemorrlhage.
Abstract LB-50: TRIM3, the human homolog of Drosophila Brat, is a tumor suppressor that regulates asymmetric cell division (ACD) in glioblastoma stem cells
Authors: Subhas Mukherjee, Gang Chen, Monika Anand, Jun Kong, Carol Tucker-Burden, Yuan Rong, Fahmia Rahman, Carlos Moreno, Erwin Van Meir, Constantinos Hadjipanayis, Daniel Brat
Journal: Cancer Research (2014)

Abstract Cancer stem cells, capable of self-renewal and multipotent differentiation, influence tumor behavior through a complex balance of symmetric and asymmetric cell divisions. Mechanisms regulating the dynamics of stem cell and their progeny in human cancer are poorly understood. In Drosophila, mutation of brain tumor (brat) leads to loss of normal asymmetric cell division by developing neural cells and results in a massively enlarged brain composed of neuroblasts with neoplastic properties. Brat promotes asymmetric cell division and directs neural differentiation at least partially through its suppression on Myc. We identified TRIM3 (11p15.5) as a human ortholog of Drosophila brat and demonstrate its regulation of asymmetric cell division and stem cell properties of glioblastoma (GBM), a highly malignant human brain tumor. TRIM3 gene expression is markedly reduced in human GBM samples, neurosphere cultures and cell lines and its reconstitution impairs growth properties in vitro and in vivo. TRIM3 expression attenuates stem-like qualities of primary GBM cultures, including neurosphere formation and the expression of stem cell markers CD133, Nestin and Nanog. In GBM stem cells, TRIM3 expression leads to a greater percentage dividing asymmetrically rather than symmetrically. As with Brat in Drosophila, TRIM3 suppresses c-Myc expression and activity in human glioma cell lines. We also demonstrate a strong regulation of Musashi-Notch signaling by TRIM3 in GBM neurospheres and neural stem cells that may better explain its effect on stem cell dynamics. We conclude that TRIM3 acts as a tumor suppressor in GBM by restoring asymmetric cell division. Citation Format: Subhas Mukherjee, Gang Chen, Monika Anand, Jun Kong, Carol Tucker-Burden, Yuan Rong, Fahmia Rahman, Carlos Moreno, Erwin Van Meir, Constantinos Hadjipanayis, Daniel Brat. TRIM3, the human homolog of Drosophila Brat, is a tumor suppressor that regulates asymmetric cell division (ACD) in glioblastoma stem cells. [abstract]. In: Proceedings of the 105th Annual Meeting of the American Association for Cancer Research; 2014 Apr 5-9; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2014;74(19 Suppl):Abstract nr LB-50. doi:10.1158/1538-7445.AM2014-LB-50
Comparison of three regimens for malaria prophylaxis in travellers to east, central, and southern Africa.
Authors: J C Wetsteyn, A de Geus
Journal: BMJ (1993)

OBJECTIVES--Confirmation of breakthroughs in three different malaria chemoprophylactic regimens (chloroquine 300 mg weekly and proguanil 100 mg daily; chloroquine 300 mg weekly and proguanil 200 mg daily; proguanil 200 mg daily) and assessment of compliance. DESIGN--Prospective, randomised multicentre trial. SETTING--Five vaccination centres in the Netherlands. SUBJECTS--Dutch travellers to east, central, and southern Africa. MAIN OUTCOME MEASURES--Plasmodium falciparum seen on blood film; concentrations of drugs measured in blood spots. RESULTS--P falciparum infection was confirmed in 12 (21%) of 58 travellers with fever suspected to be due to malaria. No difference in prophylaxis failures between the regimens was found. Breakthroughs were difficult to confirm, as compliance could be determined in only 30% of the participants with fever and chloroquine in their regimen. One breakthrough was proved. The risk per 1000 people per month for travellers was 5.4 (95% confidence interval 2.4 to 12.6) for chloroquine 300 mg weekly and proguanil 100 mg daily, 2.8 (0.9 to 10.1) for chloroquine 300 mg weekly and proguanil 200 mg daily, and 6.0 (2.6 to 14.0) for proguanil 200 mg daily. CONCLUSION--Prophylaxis failures occurred in less than 1% of the participants, and only 21% of those with a fever were suffering from falciparum malaria. Compliance was moderate. The chloroquine-proguanil combination can still be recommended for visitors to east, central, and southern Africa.
1100-56 Comparison between intracoronary infusion and direct transendocardial injection of mesenchymal stem cell in a dog acute ischemia model
Authors: Emerson C Perin, Joao A Assad, Guilherme V Silva, Stephanie Coulter, Judy Ober, Jing Lin, Andre L Sousa, Silvio Litowski, Yong Geng, Brandley J Martin, William K Vaughn, James T Willerson
Journal: Journal of the American College of Cardiology (2004)
Abstract 4370: Arsenite stabilizes HIF-1α protein through p85α-mediated upregulation of inducible Hsp70 protein expression
Authors: Wei Guo, Zhenghong Zuo, Zhuo Yang, Qing Xia, Jinyi Liu, Jingxia Li, Dongyun Zhang, Xianglin Shi, Chuanshu Huang
Journal: Cancer Research (2010)

Abstract Arsenite has long been known as a human carcinogen. The hypoxia-inducible factor-1 (HIF-1) is an important transcription factor upon hypoxia and other stresses, which is proved to be associated with the pathogenesis of several cancers. Although hypoxia-inducible factor-1α (HIF-1α) has been reported to be activated by arsenite both in vivo and in vitro, the detailed molecular mechanisms leading to HIF-1α expression and activation due to arsenite exposure have not been well understood. In the present study, we found that arsenite is able to induce HIF-1α protein accumulation in both mouse epidermal Cl41 cells and mouse embryonic fibroblasts (MEFs). Knockout of p85α in MEFs (p85α−/−) led to the deficiency of HIF-1α protein accumulation induced by arsenite exposure, suggesting that p85α is crucial for arsenite-induced stabilization of HIF-1α protein. At the same time, our studies also show that p85a exhibited an inhibition of HIF-1α protein degradation via PI-3K/Akt-dependent pathway in cellular response to arsenite exposure. Our further studies revealed that arsenite exposure was able to induce inducible Hsp70 expression, and the deficiency of HIF-1α protein in p85α−/− MEF cells could be restored by introduction of inducible Hsp70 into p85α−/− MEF (p85α−/− (Hsp70)). Moreover, our results also indicated that p85α is crucial for arsenite-induced activation of heat shock transcription factor 1 (HSF-1), which is responsible for the transcription of inducible Hsp70. The transcriptional up-regulation of hsp70 by activated PI-3K/Akt pathway is strictly mediated by heat shock transcription factor-1 (HSF-1). Taken together, our studies demonstrated that p85α-mediated HIF-1α stabilization due to arsenite exposure is specific through p85α mediation of HSF-1 activation and subsequently transcriptional up-regulation of the inducible Hsp70. During this course, p85 regulated inducible Hsp70 expression transcription through PI-3K/Akt/HSF-1 pathway upon arsenite exposure. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 101st Annual Meeting of the American Association for Cancer Research; 2010 Apr 17-21; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2010;70(8 Suppl):Abstract nr 4370.
IL-4 Controls The Phenotypic Conversion Of Effector Memory CD8+ T Cells To IL-13-Producing Cells That Enhance Allergen-Induced Airway Hyperresponsiveness And Inflammation
Authors: Y. Jia, K. Takeda, J. Han, A. Joetham, J.J. Lucas, E.W. Gelfand
Journal: Journal of Allergy and Clinical Immunology (2012)
Maternal Dioxin Exposure Combined with a Diet High in Fat Increases Mammary Cancer Incidence in Mice
Authors: Michele La Merrill, Rachel Harper, Linda S. Birnbaum, Robert D. Cardiff, David W. Threadgill
Journal: Environmental Health Perspectives (2009)

BackgroundResults from previous studies have suggested that breast cancer risk correlates with total lifetime exposure to estrogens and that early-life 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) exposure or diets high in fat can also increase cancer risk.ObjectivesBecause both TCDD and diet affect the estrogen pathway, we examined how TCDD and a high-fat diet (HFD) interact to alter breast cancer susceptibility.MethodsWe exposed pregnant female FVB/NJ mice (12.5 days postcoitus) to 1 μg/kg TCDD or vehicle; at parturition, the dams were randomly assigned to a low-fat diet (LFD) or a high-fat diet (HFD). Female offspring were maintained on the same diets after weaning and were exposed to 7,12-dimethylbenz[a]anthracene on postnatal days (PNDs) 35, 49, and 63 to initiate mammary tumors. A second cohort of females was treated identically until PND35 or PND49, when mammary gland morphology was examined, or PND50, when mammary gland mRNA was analyzed.ResultsWe found that maternal TCDD exposure doubled mammary tumor incidence only in mice fed the HFD. Among HFD-fed mice, maternal TCDD exposure caused rapid mammary development with increased Cyp1b1 (cytochrome P450 1B1) expression and decreased Comt (catechol-O-methyltransferase) expression in mammary tissue. Maternal TCDD exposure also increased mammary tumor Cyp1b1 expression.ConclusionsOur data suggest that the HFD increases sensitivity to maternal TCDD exposure, resulting in increased breast cancer incidence, by changing metabolism capability. These results provide a mechanism to explain epidemiological data linking early-life TCDD exposure and diets high in fat to increased risk for breast cancer in humans.
Highly Sensitive Cardiac Troponin T Assay, Cardiac Disease, and Mortality Risk
Authors: Peter A. Kavsak
Journal: JAMA (2011)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Detection of <i>Mycobacterium tuberculosis</i> complex DNA by the polymerase chain reaction for rapid diagnosis of cutaneous tuberculosis
Authors: N. MARGALL, E. BASELGA, P. COLL, M. A. BARNADAS, J. M. de MORAGAS, G. PRATS
Journal: British Journal of Dermatology (1996)

We assessed the polymerase chain reaction (PCR) technique to detect Mycobacterium tuberculosis complex DNA in 48 paraffin-embedded specimens from 32 patients with different variants of cutaneous tuberculosis, and compared the results with those of culture. A 123 bp product of the IS6110 insertion sequence specific of M. tuberculosis complex was amplified and confirmed by digestion with SalI restriction endonuclease. The time required for the procedure was 3 days. Thirty-seven samples (77.1%) were positive for M. tuberculosis complex DNA. No false positive results were obtained in nine negative controls. Of the 20 specimens tested by PCR and culture, the frequency of positivity was 90% for DNA amplification and 65% for culture. In seven cases of lupus vulgaris, the figures were 100% and 57%, respectively. In the 11 specimens culture negative or not microbiologically tested and PCR negative, evidence for tuberculous infection was provided by the correlation of various relative and absolute criteria. These results show that PCR amplification of the IS6110 insertion fragment is a rapid and accurate means for the detection of M. tuberculosis complex DNA in paraffin-embedded skin biopsies from patients with cutaneous tuberculosis, especially in paucibacillary lesions.
The Immunology of Parasitic Infections.
Authors: William H. Taliaferro
Journal: JAMA (1930)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The novel immunoregulatory molecule FGL2: A potential biomarker for severity of chronic hepatitis C virus infection
Authors: Katharina Foerster, Ahmed Helmy, Yi Zhu, Ramzi Khattar, Oyedele A. Adeyi, Kit Man Wong, Itay Shalev, David A. Clark, Pui-Yuen Wong, Elizabeth J. Heathcote, Melville J. Phillips, David R. Grant, Eberhard L. Renner, Gary A. Levy, Nazia Selzner
Journal: Journal of Hepatology (2010)
Variation in Plasma Calcium with Induced Changes in Plasma Specific Gravity, Total Protein, and Albumin
Authors: E. M. Berry, M. M. Gupta, S. J. Turner, R. R. Burns
Journal: BMJ (1973)

The relationship of plasma calcium levels to changes in plasma specific gravity, total protein, and albumin induced by venous stasis was investigated. Factors were derived for adjusting calcium results to offset the effects of variation in protein concentration and thus to make them of increased discriminatory value to the clinician. The validity of an existing specific gravity correction has been substantiated, but a more exact adjustment of 0.23 mg/100 ml of calcium for every 0.001 change in specific gravity is proposed. We recommend for automated laboratories that the factor based on albumin be used: 0.09 mg/100 ml of calcium should be subtracted from the total calcium value for every increase of 0.1 g in albumin above 4.6 g/100 ml, and a corresponding addition should be made for values of albumin below 4.6 g/100 ml.Using a calcium specific electrode, it has been shown that the ionized calcium concentration does not alter with prolonged venous stasis.
PROTEOSE INTOXICATIONS AND INJURY OF BODY PROTEIN
Authors: J. V. Cooke, G. H. Whipple
Journal: The Journal of Experimental Medicine (1918)

Sterile abscess, pleuritis, and pancreatitis give a clinical reaction in the experimental animal very like the same acute inflammatory processes due to bacterial activity, provided the bacterial agents are limited to the initial location. The curve of urinary nitrogen excretion in the fasting dog shows the same precipitous and sustained rise in sterile and bacterial inflammatory reactions. This indicates that the same type of protein injury and autolysis in the body is produced by the sterile inflammatory reaction as by the bacterial reaction. It is assumed that the primary effect of the chemical agent or of the bacterial growth in the tissues is local cell injury or necrosis. This injured cell protoplasm undergoes prompt autolysis with escape of toxic protein split products. These toxic protein split products may be, in part at least, of the proteose group and are absorbed into the circulation, producing the familiar general reaction. The injury of body protein is obvious from the great increase in elimination of nitrogen in the urine and appears to be the same in sterile and in bacterial inflammation. The injurious agent in the sterile inflammation must be derived from the host protein, and we may assume with safety that much of the injurious material emanating from a septic inflammation must come from the host protein rather than from the bacteria. Acute sterile pancreatitis is one of the purest examples of an acute non-specific reaction where the intensity of the host's intoxication may reach a maximum in 12 to 24 hours. We believe that fundamentally this reaction is very similar to that observed after the production of a sterile abscess or pleurisy. Non-specific intoxication must account for the sterile reactions described above. Septic inflammations show the same acute reaction and injury of body protein. The deduction is obvious-that a great part, at least, of the reaction in septic inflammation is truly non-specific and results from the primary injury of the host's protein and cell autolysis.
Combinatorial Evaluation of Cations, pH-sensitive and Hydrophobic Moieties for Polymeric Vector Design
Authors: Sharon Y Wong, Nimil Sood, David Putnam
Journal: Molecular Therapy (2009)

Three combinatorial libraries of polymeric vectors were evaluated to investigate the functional roles of molecular weight (MW), cations, pH-sensitive moieties, and hydrophobic derivitization in polymer-mediated gene delivery. Four cationic and pH-sensitive moieties (imidazole, primary, secondary, and tertiary amino) and three hydrophobic residues (C4 butyl, C6 hexyl, and C8 octyl) were assessed in single and serially incremented, binary combinations. Three MWs were evaluated-10, 30, and 50 kDa. The highest levels of transfection, comparable to branched PEI (25 kDa), were achieved by 30 kDa and 50 kDa formulations containing primary amino and imidazole groups. Primary amino groups offered superior charge-neutralizing and size-condensing capacity, while imidazole groups appeared to bind with DNA via nonelectrostatically mediated interactions to produce stable polyplexes that were resistant to premature dissociation. Eight of the 10 highest-transfecting polymers possessed IC(50) values greater than the maximum concentration of free polymers exposed to cells (200 microg/ml). The results herein have identified highly efficient polymeric formulations with superb toxicity profiles and have revealed the functional roles that the investigated pendant groups play in the transfection process. The reported polymeric system offers a versatile and robust platform upon which future structure-function studies may be based to create safer and more efficient polymeric vectors.
Bone Mineral Density in Non-Insulin-Dependent Diabetes Mellitus
Authors: Paulus L. A. van Daele
Journal: Annals of Internal Medicine (1995)

Letters1 November 1995Bone Mineral Density in Non-Insulin-Dependent Diabetes MellitusPaulus L. A. van Daele, MD, Jan C. Birkenhager, MD, and Huibert A. P. Pols, MDPaulus L. A. van Daele, MDAcademisch Ziekenhuis Rotterdam; 3015 GD Rotterdam; the NetherlandsSearch for more papers by this author, Jan C. Birkenhager, MDAcademisch Ziekenhuis Rotterdam; 3015 GD Rotterdam; the NetherlandsSearch for more papers by this author, and Huibert A. P. Pols, MDAcademisch Ziekenhuis Rotterdam; 3015 GD Rotterdam; the NetherlandsSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-123-9-199511010-00018 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail IN RESPONSE:We thank Dr. McKenna for his valuable comments. Indeed, some studies suggest that diabetes is associated with a low bone turnover [1, 2], which might result in a diminution of age-related bone loss in patients with non–insulin-dependent diabetes mellitus. However, this hypothesis is not supported by our recent finding that the rate of bone loss in our patients with non–insulin-dependent diabetes mellitus is not decreased [3].We agree that it would be interesting to examine whether patients with non–insulin-dependent diabetes mellitus have more stress fractures. However, because all fractures in this study were self-reported, we do not have ...References1. Verhaeghe J, van Herck E, Visser WJ, Suiker AM, Thomasset M, Einhorn TA, et al. Bone and mineral metabolism in BB rats with long-term diabetes. Decreased bone turnover and osteoporosis. Diabetes. 1990; 39:477-82. Google Scholar2. Krakauer JC, McKenna MJ, Rao DS, Fenn NS, Parfitt AM, Whitehouse FW. Long term preservation of bone mass in diabetes mellitus. Calcif Tissue Int. 1993; 52(Suppl 2):S27. Google Scholar3. van Daele PL, Stolk RP, Burger H, et al. Rates of bone loss in subjects with and without non–insulin-dependent diabetes mellitus. The Rotterdam Study. Bone. 1995; 16(Suppl 1):187S. Google Scholar Author, Article, and Disclosure InformationAffiliations: Academisch Ziekenhuis Rotterdam; 3015 GD Rotterdam; the Netherlands PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 November 1995Volume 123, Issue 9Page: 731KeywordsBone densityBone remodelingBone resorptionOsteoporosisType 2 diabetes Issue Published: 1 November 1995 CopyrightCopyright © 1995 by American College of Physicians. All Rights Reserved.PDF DownloadLoading ...