INTRAHEPATIC OBSTRUCTIVE JAUNDICE FOLLOWING THE ADMINISTRATION OF 75 MG. OF CHLORPROMAZINE
Authors: E E WOLDMAN, D FISHMAN
Journal: Annals of Internal Medicine (1957)

Case Reports1 August 1957INTRAHEPATIC OBSTRUCTIVE JAUNDICE FOLLOWING THE ADMINISTRATION OF 75 MG. OF CHLORPROMAZINEEDWARD E. WOLDMAN, M.D., F.A.C.P., DAVID FISHMAN, M.D.EDWARD E. WOLDMAN, M.D., F.A.C.P.Search for more papers by this author, DAVID FISHMAN, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-47-2-332 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptChlorpromazine (Thorazine) is being widely used in the treatment of various psychiatric disorders,1 the nausea and vomiting of diverse etiology,2 intractable hiccups,3 and as an analgesic.4 The sedative, tranquilizing and calming properties of the drug also make it useful as an adjunct in the treatment of a variety of conditions.Numerous side-effects have been noted following the administration of chlorpromazine, but most of them are usually not severe enough to warrant discontinuing the drug therapy. However, one of the most disturbing side-effects of this therapy is jaundice, which has been reported quite frequently during this last year. The laboratory observations...Bibliography1. LehmannHanrahan HEGE: Chlorpromazine: a new inhibiting agent for psychomotor excitement and manic states, Arch. Neurol. and Psychiat. 71: 227-237 (Feb.) 1954. CrossrefGoogle Scholar2. FriendCummins DGJF: New antiemetic drug: preliminary report, J. A. M. A. 153: 480 (Oct. 3) 1953. CrossrefMedlineGoogle Scholar3. FriedgoodRipstein CECB: Chlorpromazine (Thorazine) in treatment of intractable hiccups, J. A. M. A. 157: 309 (Jan. 22) 1955. CrossrefMedlineGoogle Scholar4. SadoveLevinRoseSchwartzWitt MSMJRFLFW: Chlorpromazine and narcotics in the management of pain of malignant lesions, J. A. M. A. 155: 626-628 (June 12) 1954. CrossrefMedlineGoogle Scholar5. LemireMitchell RERA: Regurgitation type jaundice associated with chlorpromazine (Thorazine) administration, J. Lab. and Clin. Med. 44: 285 (Nov.) 1954. Google Scholar6. ZatuchniMiller JG: Jaundice during chlorpromazine therapy, New England J. Med. 251: 1003-1006 (Dec. 16) 1954. CrossrefMedlineGoogle Scholar7. Boardman RH: Fatal case of toxic hepatitis implicating chlorpromazine, Brit. M. J. 2: 579 (Sept. 4) 1954. CrossrefMedlineGoogle Scholar8. SussmanSumner RMP: Jaundice following the administration of 50 mg. of chlorpromazine, New England J. Med. 253: 499-502 (Sept. 22) 1955. CrossrefMedlineGoogle Scholar9. CohenArcher IMJD: Liver function and hepatic complications in patients receiving chlorpromazine, J. A. M. A. 159: 99-101 (Sept. 10) 1955. CrossrefMedlineGoogle Scholar10. Van OmmenBrown RACH: Obstructive-type jaundice due to chlorpromazine (Thorazine), J. A. M. A. 157: 321-325 (Jan. 22) 1955. CrossrefMedlineGoogle Scholar11. Harnett BS: Liver damage and eosinophilia following chlorpromazine therapy: report of a case, Brit. M. J. 1: 1458 (June 18) 1955. CrossrefMedlineGoogle Scholar12. WernerHangerKritzler SCFMRA: Jaundice during methyl testosterone therapy, Am. J. Med. 8: 325-331 (Mar.) 1950. CrossrefMedlineGoogle Scholar13. GargillLesses SLMF: Toxic reactions to thiouracil: report of cases with one fatality, J. A. M. A. 127: 890-898 (Apr. 7) 1945. CrossrefGoogle Scholar14. HangerGutman FMAB: Postarsphenamine jaundice, apparently due to obstruction of intrahepatic biliary tract, J. A. M. A. 115: 263-271 (July 27) 1940. CrossrefGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Cleveland, Ohio*Received for publication April 17, 1956.From the Department of Gastroenterology, St. Luke's Hospital, Cleveland, Ohio.Requests for reprints should be addressed to Edward E. Woldman, M.D., 1021 Prospect Avenue, Cleveland 15, Ohio. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byPsychological Consequences of Drug JaundicePHARMACOLOGY OF HEPATOTOXIC AGENTSCLINICAL AND LABORATORY MANIFESTATIONS OF HEPATOTOXICITYDRUG-INDUCED HEPATIC INJURY*HANS POPPER, M.D., F.A.C.P., FENTON SCHAFFNER, M.D., F.A.C.P.HEPATIC DYSFUNCTION DUE TO CHLORPROMAZINE HYPERSENSITIVITY*LEO WAITZKIN, M.D.Drug reactions characterized by cholestasis associated with intrahepatic biliary tract obstruction 1 August 1957Volume 47, Issue 2Page: 332-338KeywordsChlorpromazineDrug therapyDrugsIngestionNauseaPhosphatasesResearch laboratoriesRespirationSedativesVomiting ePublished: 1 December 2008 Issue Published: 1 August 1957 PDF downloadLoading ...