tbuckley/cabot-search huggingface dataset:
Health Policy 2001 — A New Series
Authors: Arnold M. Epstein, Jeffrey M. Drazen, Robert Steinbrook
Journal: New England Journal of Medicine (2001)

The American health care system remains a paradox of abundance and weaknesses.1 It is the most expensive health care system in the developed world. Its academic medical centers deliver sophisticated care to patients with complex and serious illnesses. The United States is also a leader in developing new forms of medical technology and new medications. Although these innovations have had substantial benefits for health, they have also contributed to soaring health care costs. In addition, there is starvation in the midst of plenty: more than 40 million people lack health insurance, and millions of insured have inadequate coverage. Thus, many . . .
Radial keratotomy findings released; some still wary
Authors: Carol Fletcher
Journal: JAMA (1985)

Long-awaited results of a National Eye Institute study, released recently in Atlanta, have focused attention anew on radial keratotomy, an operation to reduce myopia by changing the shape of an otherwise healthy cornea (<i>Arch Ophthalmol</i>1984;102:1601-1603). The surgery, for which more than 10 million Americans might be candidates, has been performed an estimated 63,000 to 100,000 times in the United States since 1978 (<i>Keratorefraction</i>, Denison, Tex, LAL Publishing, 1980, pp 175-181, and<i>Arch Opthalmol</i>1984;102:1612-1617) at charges ranging from $1,000 to $3,000 for each eye. Some third-party payers reimburse for the procedure. However, many ophthalmologists are still wary of the procedure, claiming that its outcome is unpredictable and long-term effects unknown. To help assess the safety and efficacy of the operation, the National Eye Institute (which is in Bethesda, Md) in 1980 undertook sponsorship of the Prospective Evaluation of Radial Keratotomy, often referred to by its acronym, PERK, at nine
Polypill for Cardiovascular Disease Prevention—Reply
Authors: Richard Smith, Tara McCready, Salim Yusuf
Journal: JAMA (2013)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2022 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Prognostic Significance of Delayed-Enhancement Magnetic Resonance Imaging
Authors: Benjamin Y.C. Cheong, Raja Muthupillai, James M. Wilson, Angela Sung, Steffen Huber, Samir Amin, MacArthur A. Elayda, Vei-Vei Lee, Scott D. Flamm
Journal: Circulation (2009)

Left ventricular ejection fraction is a powerful independent predictor of survival in cardiac patients, especially those with coronary artery disease. Delayed-enhancement magnetic resonance imaging (DE-MRI) can accurately identify irreversible myocardial injury with high spatial and contrast resolution. To date, relatively limited data are available on the prognostic value of DE-MRI, so we sought to determine whether DE-MRI findings independently predict survival.The medical records of 857 consecutive patients who had complete cine and DE-MRI evaluation at a tertiary care center were reviewed regardless of whether the patients had coronary artery disease. The presence and extent of myocardial scar were evaluated qualitatively by a single experienced observer. The primary, composite end point was all-cause mortality or cardiac transplantation. Survival data were obtained from the Social Security Death Index. The median follow-up was 4.4 years; 252 patients (29%) reached one of the end points. Independent predictors of mortality or transplantation included congestive heart failure, ejection fraction, and age (P<0.0001 for each), as well as scar index (hazard ratio, 1.26; 95% confidence interval, 1.02 to 1.55; P=0.033). Similarly, in subsets of patients with or without coronary artery disease, scar index also independently predicted mortality or transplantation (hazard ratio, 1.33; 95% confidence interval, 1.05 to 1.68; P=0.018; and hazard ratio, 5.65; 95% confidence interval, 1.74 to 18.3; P=0.004, respectively). Cox regression analysis showed worse outcome in patients with any DE in addition to depressed left ventricular ejection fraction (<50%).The degree of DE detected by DE-MRI appears to strongly predict all-cause mortality or cardiac transplantation after adjustment for traditional, well-known prognosticators.
EGF Gene Polymorphism and the Risk of Incident Primary Melanoma
Authors: Kandace L. Amend, James T. Elder, Lynn P. Tomsho, Joseph D. Bonner, Timothy M. Johnson, Jennifer Schwartz, Marianne Berwick, Stephen B. Gruber
Journal: Cancer Research (2004)

Abstract Overexpression of the epidermal growth factor (EGF) pathway has been implicated in melanoma pathogenesis, and a recent case-control study identified a single nucleotide polymorphism (G to A) in the EGF gene where the G allele was associated with increased EGF expression and an increased risk of melanoma. To further evaluate this association, we conducted a case-control analysis from the Genes, Environment, and Melanoma study at the University of Michigan site using two different study designs. Incident cases of histopathologically confirmed first primary melanoma that were diagnosed between January 1, 2000 and December 31, 2000 from the University of Michigan Melanoma Clinic (n = 330) were compared with the following two different sources of nonmelanoma controls: spouse/friend controls (n = 84) and healthy volunteer controls from a case-control study of psoriasis (n = 148). Using a second analytic design, comparisons between multiple primary melanoma cases (n = 62) and single primary melanoma cases (n = 330) were also evaluated to estimate odds ratios (ORs). Genotyping for the single nucleotide substitution (G to A) at position 61 in the 5′ untranslated region of the EGF gene was performed from genomic DNA, and epidemiological risk factors were assessed through a telephone interview. When EGF genotypes were compared between incident primary melanoma cases and the nonmelanoma controls, the risk associated with the homozygous G/G genotype was not statistically significantly associated with an increased risk for incident primary melanoma compared with the homozygous A/A genotype [OR, 1.09; 95% confidence interval (CI); 0.65–1.85]. No strong associations with EGF G/G genotype were observed in comparisons of multiple primary and single primary melanoma cases (OR, 0.66; 95% CI; 0.25–1.73). Case subjects with tumors ≥3.5 mm compared with those &amp;lt;3.5 mm were not significantly associated with the G/G genotype (OR, 0.54; 95% CI; 0.12–2.35). Our data do not support a significant association between melanoma and the EGF 61*G allele or the homozygous G/G genotype. The EGF polymorphism is not a reproducible risk factor for melanoma or thick melanoma in our data. The two analytic approaches used in the study provide evidence against a strong association between EGF 61*G and melanoma and demonstrate the potential utility of case-case designs for evaluating the role of single nucleotide polymorphisms and cancer. Additional independent studies will be required to elucidate relationships between genetic variation in the EGF gene and risk of melanoma.
Lobbying bill will stifle debate, say BMA and charities
Authors: C. Dyer
Journal: BMJ (2013)

The UK government is coming under growing pressure to amend its proposed new lobbying law, as dozens of organisations, including the BMA, argue that it will stifle free speech and the watchdog that will have to enforce it questions its workability.

The Transparency of Lobbying, Non-party Campaigning and Trade Union Administration Bill had its second reading in the House of Commons on 3 September and is due to go to the committee stage on 9 September.

But the BMA has joined dozens of other organisations, including pressure groups, …
Medical Evidence in Railway Accidents
Authors: J. C. Hall
Journal: BMJ (1868)

dhdemypaper, consious tt theimpornne ofthe demds unch greter care and research than up to the present I timeto gi ttl; and hopeful that, in the aon of such question, we wil cfteely availourselves of the labours of naturl plosophers than Ilithertohas been done, and thus place physiology in its proper position ara-beaifuland all-importat science.
Association of calpain 10 gene polymorphisms with type 2 diabetes mellitus in Southern Indians
Authors: Dhanasekaran Bodhini, Venkatesan Radha, Saurabh Ghosh, Krishna R. Sanapala, Partha P. Majumder, Manchanahalli Rangaswamy Satyanara Rao, Viswanathan Mohan
Journal: Metabolism (2010)
WHOLE BODY PET F-18 FDG IN CARCINOMA PATIENTS INITIAL RESULTS FIRST 100+ PATIENTS
Authors: V Cronin, P. Galantowicz, D. Lamonica, J. Gona, H. A. Nabi
Journal: Clinical Nuclear Medicine (1995)

Cronin, V CNMT; Galantowicz, P. CNMT; Lamonica, D. MD; Gona, J. MD; Nabi, H. A. MD. PhD. Author Information
Absence of True Seroreversion of HIV-1 Antibody in Seroreactive Individuals
Authors: Michael J. Roy
Journal: JAMA (1993)

First, to determine whether there is evidence for loss of human immunodeficiency virus type 1 (HIV-1) antibody in seroreactive individuals. Second, if true seroreversion occurs, to determine its incidence relative to errors in the testing process.A retrospective cohort study reviewing the results of 5,446,161 HIV-1 antibody tests performed on 2,580,974 individuals (the US Army HIV Data System) from 1985 through 1992. For all patients with one or more seroreactive sample followed by one or more nonreactive sample, we examined available records and retested the samples.Serum samples had been obtained from active-duty and retired military personnel, their dependents, and applicants to the military.Of 4911 individuals reported to be seroreactive for HIV-1 by two independent samples, only six were potential seroreverters. Review of the six cases revealed that five actually were HIV-seroreactive patients who had samples from nonreactive individuals mistakenly attributed to them, while the sixth had a testing error proven by retesting the discrepant specimen. Errors in the testing process were identified (n = 23) or suspected (n = 3) in another 26 individuals who had not had independent confirmation of reactivity by a second sample. The cumulative error rate was 12.4 per 1 million patients tested. An additional group of 31 uninfected infants appeared to serorevert due to loss of antibody acquired from their HIV-1-infected mothers.Review of this database demonstrates no evidence for true seroreversion of HIV-1 antibody status. We conclude that if seroreversion occurs at all, it is exceedingly rare. In fact, most (if not all) cases of apparent seroreversion represent errors of attribution or testing.
ON DIATHESIS IN INFANCY: A PLEA FOR ITS CLOSER STUDY
Authors: H. C. Cameron
Journal: BMJ (1914)

article publislhed recently, entitled " Infant Mortality, Ancient and Modern," referred to the prejudicial influence which was exerted in England by tlle growing tendency to enlcourage lay 'workers and miiembers of the nursing pro- fession to busy thiemselves witlh the doctrinies of infant lhygiene and tlle practice of infant dietetics.Professor Holt's words are:If in England the measures referred to have beeni much less successful than in other countries, we must remember that in that country the care and feedinig of the infanit is generally believed to be the special province of the nurse.The physician is frequently not consulted at all.The effect of this is seeni in
Quality Trials and Quality of Life in Non–Small-Cell Lung Cancer
Authors: Peter Harper, Tim Plunkett, David Khayat
Journal: Journal of Clinical Oncology (2003)

Article Tools EDITORIALS Article Tools OPTIONS & TOOLS Export Citation Track Citation Add To Favorites Rights & Permissions COMPANION ARTICLES No companion articles ARTICLE CITATION DOI: 10.1200/JCO.2003.05.079 Journal of Clinical Oncology - published online before print September 21, 2016 PMID: 12837809 Quality Trials and Quality of Life in Non–Small-Cell Lung Cancer Peter HarperxPeter HarperSearch for articles by this author , Tim PlunkettxTim PlunkettSearch for articles by this author , David KhayatxDavid KhayatSearch for articles by this author Show More 1Department of Medical Oncology, Guy’s and St Thomas’ Hospital, London, UK2Hopital La Pitie Salpetriere, Paris, France https://doi.org/10.1200/JCO.2003.05.079 Full Text PDF Figures and Tables "Quality Trials and Quality of Life in Non–Small-Cell Lung Cancer." Journal of Clinical Oncology, 21(16), pp. 3007–3008© 2003 by American Society of Clinical Oncology
Effects of budesonide by means of the Turbuhaler on the hypothalmic-pituitary-adrenal axis in asthmatic subjects: A dose-response study☆☆☆★★★
Authors: Donald Aaronson, Harold Kaiser, Robert Dockhorn, Steven Findlay, Philip Korenblat, Lars Thorsson, Anders Källén
Journal: Journal of Allergy and Clinical Immunology (1998)
Grade A Eggs as a Source of Salmonella enteritidis Infections-Reply
Authors: Michael E. St. Louis
Journal: JAMA (1989)

<h3>In Reply.—</h3> Mr Thomas evidently misunderstood the epidemiologic methods that were the core of our report. We did not interview persons 1 or 2 years after their illness. Rather, state and local health departments routinely investigate food-borne disease outbreaks at the time of occurrence, recording specific epidemiologic data such as food-specific attack rates and microbiological tests of foods. The epidemiologic findings we reported from 1985 through 1987 therefore represented an analysis of the aggregate results from an extensive series of independent investigations of food-borne disease outbreaks reported to the Centers for Disease Control. Our ability to collect and analyze 65<i>S enteritidis</i>outbreaks occurring in the northeastern United States testifies to the extraordinary rise of this one serotype of<i>Salmonella</i>as an agent of food-borne disease in recent years. Grade A eggs or foods containing such eggs were implicated in 77% of these<i>S enteritidis</i>outbreaks in which the vehicle
Survival in Systemic Lupus Erythematosus
Authors: Daniel A. Albert
Journal: JAMA (1978)

<h3>To the Editor.—</h3> We commend Urman and Rothfield (238:2272-2276, 1977) for their analysis of the large groups of cases of systemic lupus erythematosus (SLE) followed at Bellevue Hospital and Clinic and the University of Connecticut Hospital and Clinics. Although it adds to a growing literature that supports the contention that the survival of patients with lupus is improving, it does not clarify the reasons for this improved survival. There were many improvements in diagnosis and therapy during the years that this study covered. These included easier screening for lupus with the routine use of the antinuclear antibody, multiple new antibiotics, widespread use of peritoneal dialysis and hemodialysis, and other general supportive measures. The effect of the diagnostic changes was to widen the pool of patients with SLE by including patients who were less ill and had better prognoses. In addition, the new therapeutic measures improved the chances of the most
Post-mortem studies in glioblastoma patients treated with thermotherapy using magnetic nanoparticles
Authors: Frank K.H. van Landeghem, K. Maier-Hauff, A. Jordan, Karl-Titus Hoffmann, U. Gneveckow, R. Scholz, B. Thiesen, W. Brück, A. von Deimling
Journal: Biomaterials (2008)
Non-selective betablocker therapy decreases intestinal permeability and serum levels of LBP and IL-6 in patients with cirrhosis
Authors: Thomas Reiberger, Arnulf Ferlitsch, Berit A. Payer, Mattias Mandorfer, Birgit B. Heinisch, Hubert Hayden, Frank Lammert, Michael Trauner, Markus Peck-Radosavljevic, Harald Vogelsang
Journal: Journal of Hepatology (2012)
Deficient innate immunity and susceptibility of asthmatics to infection
Authors: A Adams
Journal: Thorax (2006)

▴ Contoli M, Message SD, Laza-Stanca V, et al. Role of deficient type III interferon-λ production in asthma exacerbations. Nat Med2006;12:1023–6 [OpenUrl][1][CrossRef][2][PubMed][3][Web of Science][4] Rhinoviruses are a major cause of asthma exacerbations. Asthmatics may have increased susceptibility to rhinoviral (and bacterial) infections but the mechanisms involved are not known. This study aimed to identify a possible mechanism of susceptibility involving induction of type III interferon, interferon λ. Primary bronchial epithelial cells from asthmatic and normal subjects … [1]: {openurl}?query=rft.jtitle%253DNature%2Bmedicine%26rft.stitle%253DNat%2BMed%26rft.aulast%253DContoli%26rft.auinit1%253DM.%26rft.volume%253D12%26rft.issue%253D9%26rft.spage%253D1023%26rft.epage%253D1026%26rft.atitle%253DRole%2Bof%2Bdeficient%2Btype%2BIII%2Binterferon-lambda%2Bproduction%2Bin%2Basthma%2Bexacerbations.%26rft_id%253Dinfo%253Adoi%252F10.1038%252Fnm1462%26rft_id%253Dinfo%253Apmid%252F16906156%26rft.genre%253Darticle%26rft_val_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Ajournal%26ctx_ver%253DZ39.88-2004%26url_ver%253DZ39.88-2004%26url_ctx_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Actx [2]: /lookup/external-ref?access_num=10.1038/nm1462&link_type=DOI [3]: /lookup/external-ref?access_num=16906156&link_type=MED&atom=%2Fthoraxjnl%2F61%2F12%2F1053.atom [4]: /lookup/external-ref?access_num=000240373900025&link_type=ISI
Packing My Bag for the Road Ahead
Authors: Nancy W. Dickey
Journal: JAMA (1998)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Evaluation of the role of contact sensitization and photosensitivity in the pathogenesis of poikiloderma of Civatte
Authors: A.C. Katoulis, N.G. Stavrianeas, A. Katsarou, C. Antoniou, S. Georgala, D. Rigopoulos, E. Koumantaki, G. Avgerinou, A.D. Katsambas
Journal: British Journal of Dermatology (2002)

Poikiloderma of the face and neck (Civatte) is a rather common, indolent, chronic dermatosis, most often affecting menopausal females. Cumulative excessive sun exposure, a phototoxic or a photoallergic reaction, hormonal changes of menopause and genetic factors have all been incriminated in its obscure aetiopathogenesis.To evaluate the role of contact sensitization and photosensitivity in the pathogenesis of poikiloderma of Civatte (PC).Thirty-two patients (24 females and eight males, age range 38-74 years) with PC were patch tested with the European standard series and the fragrance series, and were photopatch tested with the photoallergens series. Additionally, photo-testing with a monochromator was performed.Thirteen of 32 patients (40.62%) had one or more positive reactions to allergens of the standard series. Eight patients (25%) had positive reactions to fragrance mix and/or Balsam of Peru, which are included in the standard series, or to allergens of the fragrance series. Nickel sulphate was the single most common cause of contact sensitization (18.75%) among our patients. Ninety-seven subjects, who were patch tested with the standard series for suspected allergic contact dermatitis of the face and/or neck, served as age, sex and site controls. Of these, nine (9.27%) had one or more positive reactions to fragrance compounds. Statistical analysis showed a statistically significant difference in the frequency of positive reactions to fragrances between the PC group and the control group (chi2 value = 3.91, P < 0.05). In contrast, none of the PC patients had a positive photopatch test for the allergens included in the photoallergens series. The estimated minimal erythemal dose for the PC group was in all cases within normal limits for all wavelengths of ultraviolet (UV) radiation examined.Contact sensitization, mostly to perfume ingredients, may develop in PC, possibly playing a pathogenetic part, at least in a subset of patients. Despite negative results of photopatch testing, an allergic photo-contact reaction cannot be definitely excluded. PC seems not to be a photosensitivity disorder of the type of chronic actinic dermatitis. UV radiation-induced dermal connective tissue changes are the predominant histological feature of PC, leading to telangiectasia due to loss of vascular support. Reticular pigmentation may result from a delayed hypersensitivity reaction to perfume and/or cosmetic ingredients. Patch testing with the standard series and avoidance of documented allergens may be of value in patients with PC.
T cell stimulation by dendritic cell-tumor cell hybrids is enhanced in the presence of free dendritic cells
Authors: Mariana P Pinho, Patricia C Bergami-Santos, José Alexandre M Barbuto
Journal: Journal for ImmunoTherapy of Cancer (2013)

Meeting abstracts Dendritic cell-tumor cell hybrids (heterokaryons) are under investigation as a means for tumor immunotherapy since they should express MHC class I molecules from both cell types and, thus, present tumor antigens within an immunogenic context. The aim of this work was, therefore,
Horner's syndrome and demyelinating peripheral neuropathy caused by high‐dose cytosine arabinoside
Authors: T. J. Nevill, T. J. Benstead, C. W. McCormick, O. A. Hayne
Journal: American Journal of Hematology (1989)

Abstract High‐dose cytosine arabinoside may benefit patients with refractory acute leukemia. Peripheral nervous system disturbances caused by cytosine arabinoside have rarely been reported. We describe a patient with acute leukemia who developed Horner's syndrome and a severe demyelinating peripheral neuropathy leading to death after receiving highdose cytosine arabinoside. Peripheral nerve dysfunction is a potentially serious complication of high‐dose cytosine arabinoside.