tbuckley/cabot-search huggingface dataset:
Earthquakes and Takotsubo Cardiomyopathy—Reply
Authors: Hiroshi Watanabe, Makoto Kodama, Yoshifusa Aizawa, Naohito Tanabe
Journal: JAMA (2005)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
An IL6 promoter polymorphism is associated with a lifetime risk of development of Kaposi sarcoma in men infected with human immunodeficiency virus
Authors: Charles B. Foster, Thomas Lehrnbecher, Susan Samuels, Steven Stein, Femke Mol, Julie A. Metcalf, Kathleen Wyvill, Seth M. Steinberg, Joseph Kovacs, Andrew Blauvelt, Robert Yarchoan, Stephen J. Chanock
Journal: Blood (2000)
New Findings on Anthrax Toxin
Authors: Joan Stephenson
Journal: JAMA (2001)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Abstract P1-06-04: Super-enhancer analysis defines breast cancer subtype and identifies tumor dependencies
Authors: Matthew G Guenther, David A Orlando, Matthew L Eaton, Cindy A Collins, Mei Wei Chen, Sneha Solanki, Jakob Loven, Christian C Fritz, Eric R Olson
Journal: Cancer Research (2015)

Abstract Epigenomic modifications define gene regulatory features that control transcription and disease cell state. Recent studies of these regulatory features have identified large clusters of enhancers, termed super-enhancers, which define key cell identity and disease genes. Using ChIP-seq and RNA-seq analysis, we have discovered Super-enhancers in breast cancer cell line models and in primary tissue and have characterized their roles in establishing tumor cell state. We find that Super-enhancers recapitulate clinical subgroups in both breast cancer cell line models and in invasive ductal carcinoma. Super-enhancer-associated genes encode known and novel therapeutic targets including kinases, phosphatases, chromatin regulators and transmembrane proteins. Such genes include key drivers such as ERRB2 in HER2+ patient samples, ESR1 in estrogen receptor positive samples, and CCND1 in samples of luminal subtype. We describe the biological and disease relevance of Super-enhancer-associated genes in the context of tumor cell state and drug target discovery. Citation Format: Matthew G Guenther, David A Orlando, Matthew L Eaton, Cindy A Collins, Mei Wei Chen, Sneha Solanki, Jakob Loven, Christian C Fritz, Eric R Olson. Super-enhancer analysis defines breast cancer subtype and identifies tumor dependencies [abstract]. In: Proceedings of the Thirty-Seventh Annual CTRC-AACR San Antonio Breast Cancer Symposium: 2014 Dec 9-13; San Antonio, TX. Philadelphia (PA): AACR; Cancer Res 2015;75(9 Suppl):Abstract nr P1-06-04.
Lantadene A induced apoptosis in human leukemia HL-60 cells
Authors: sharma manu, P. D Sharma
Journal: Clinical Cancer Research (2007)

AACR Centennial Conference: Translational Cancer Medicine-- Nov 4-8, 2007; Singapore

B36 

Lantadene A (LA, 22β-angeloyloxy-3-oxoolean-12-en-28-oic acid) a pentacyclic triterpenoid isolated from leaves of obnoxious weed Lantana camara L. was evaluated for apoptosis induction in human leukemia HL-60 cell line. The effect of LA on cell proliferation of HL-60 cancer cells were determined by MTT assay. The morphological effects of LA treated HL-60 cancer cells were observed under a fluorescence microscope. DNA fragmentation was observed using gel electrophoresis. Flow cytometry was carried out to observe changes in cell-cycle distribution of the cells. The expression of Bcl-2 and Bax proteins in HL-60 cells were visualized by means of immunohistochemical assay and cell viability was determined upon treatment with DEVD-CHO and LA. Typical morphological changes including cell shrinkage, chromatin condensation and characteristic DNA ladder formation in agarose gel electrophoresis were observed. LA induced marked concentration and time dependant inhibition of cancer cell proliferation with IC50 value of 19.8 ± 0.10 μg/ml following 48h incubation. Flow cytometric analysis showed suppressed cell proliferation associated with cell cycle arrest in the G/G1 phase. LA significantly inhibited cell proliferation of HL-60 cells and induced cell apoptosis through down regulating Bcl-2 and up regulating Bax expression. The peptidic caspase-3 inhibitors DEVD-CHO (NH2-Asp-Glu-Val-Asp-CHO, 2µM), increased the viability of HL-60 cells, previously treated with LA. The results indicated that LA induced efficient cell apoptosis by activating the caspase-3 pathway and through down and up regulation of Bcl-2 and Bax expression respectively.
A radiation hybrid map of the zebrafish genome
Authors: Robert Geisler, Gerd-Jörg Rauch, Herwig Baier, Frauke van Bebber, Linda Broβ, Marcus P.S. Dekens, Karin Finger, Cornelia Fricke, Michael A. Gates, Horst Geiger, Silke Geiger-Rudolph, Darren Gilmour, Stefanie Glaser, Lara Gnügge, Hinrich Habeck, Katy Hingst, Scott Holley, Jeremy Keenan, Anette Kirn, Holger Knaut, Deval Lashkari, Florian Maderspacher, Ulrike Martyn, Stephan Neuhauss, Carl Neumann, Teresa Nicolson, Francisco Pelegri, Russell Ray, Jens M. Rick, Henry Roehl, Tobias Roeser, Heike E. Schauerte, Alexander F. Schier, Ulrike Schönberger, Helia-Berrit Schönthaler, Stefan Schulte-Merker, Catrin Seydler, William S. Talbot, Christian Weiler, Christiane Nüsslein-Volhard, Pascal Haffter
Journal: Nature Genetics (1999)
Abstract 233: What Is the Evidence for the Use of Automated External Defibrillators in Infants?
Authors: Joseph W Rossano, Wendell Jones, Stamatious Lerakis, Michael Millin, Ira Nemeth, Pascal Cassan, Joan Shook, Sioban Kennedy, David Markenson, Richard N Bradley
Journal: Circulation (2014)

Background:  Automated external defibrillators (AEDs) have been used successfully in many populations to improve survival for out-of-hospital cardiac arrest. While ventricular fibrillation and pulseless ventricular tachycardia are more prevalent in adults, these arrhythmias do occur in infants. Historically, there has been controversy about the safety and efficacy of AEDs in this population. Therefore, we conducted a systematic review on the use of AEDs in infants.   Methods:  The Cochrane library and Pubmed were searched for relevant studies that included automated external defibrillators in infants, any external defibrillation in infants, and simulation studies of algorithms used by AEDs on pediatric arrhythmias.   Results:  There were four studies on the accuracy of AEDs in recognizing pediatric arrhythmias. The algorithms used by AEDs had high sensitivity and specificity for pediatric arrhythmias and very rarely recommended a shock inappropriately. Case reports (n=2) demonstrated successful use of AED in infants and a retrospective review (n=1) of pediatric pads for AEDs included infants. Six studies addressed defibrillation dosages used. The energy doses delivered by AEDs were high, though in the range that have been used in out-of-hospital arrest. Additionally, there were data to suggest that 2-4 J/kg may not be effective defibrillation doses for many children.   Conclusions:  There are limited data from clinical studies on AED use if infants and no randomized clinical trials. However, available evidence suggests that AEDs are safe and effective in this population. As survival is unlikely in the absence of prompt defibrillation for ventricular fibrillation or pulseless ventricular tachycardia, AEDs should be used in infants with suspected cardiac arrest.
Hepatocellular carcinoma
Authors: Salvatore Ricca Rosellini, Vincenzo Arienti, Oriana Nanni, Francesca Ugenti, Maurizio Tassinari, Claudio Camporesi, Luciana Boriani, Giovanna Versari, Pier Lorenzo Costa, Dino Amadori, Federico Miglio, Giovanni Gasbarrini
Journal: Journal of Hepatology (1992)
Rapid direct antibiotic susceptibility testing in endophthalmitis 1 1The authors have no commercial interest in any of the materials or methods used in this study.
Authors: Herminia Miño de Kaspar, Aljoscha S Neubauer, Alexander Molnar, Angela S Hoepfner, Christopher N Ta, Thomas Grasbon, Michael Engelbert, Martin Thiel, Volker Klauss, Anselm Kampik
Journal: Ophthalmology (2002)
Development of binary forecast models of asthma exacerbation: Asthma index
Authors: Jae-Won Oh, Joo-Hwa Kim, Yoon-Seok Chang, Keon-Tae Sohn
Journal: European Respiratory Journal (2014)

Background:  Asthma is one of the most common chronic diseases worldwide, and a growing public health concern. It is characterized by chronic bronchial inflammation and a multi-factorial etiology that includes genetic, immunological and environmental factors. Our goal was to develop a patient-customizable asthma forecasting system that takes into account meteorological factors, air pollution, and pollen and viral respiratory infections, which are the most common environmental factors known to exacerbate asthma.   Methods:  We analyzed the health insurance records of patients who visited the emergency departments in Seoul due to an asthma attack and who were treated with salbutamol. Our potential predictors of asthma symptoms included meteorological factors (temperature, humidity, air pressure, and amount of sunshine), air pollution factors (ozone and Asian yellow dust), environmental factors (pollen) and health-related factors (seasonal influenza viral infection). Patients were assigned to five age groups and separated according to gender and season (5 × 2 × 4 groups), which resulted in a total of 40 groups. Three models (a multiple regression model, a logistic regression model, and a decision tree) were tested for their ability to predict exacerbated asthma symptoms (referred to as “attention” symptoms). The suitability of the final model was assessed using predictability skill scores.   Results:  Logistic regression and the decision tree provided the best forecasts. Using the estimated binary values for “continuous management” versus “attention” symptoms, the optimal threshold was selected.   Conclusions:  Our binary forecasting model may improve the prediction of asthma exacerbation in a clinical setting.
A quantitative comparison of protoporphyrin IX pharmacokinetics and phototoxicity in human skin following iontophoretic delivery of the pro-drugs 5-aminolevulinic acid and 5-aminolevulinic-n-pentylester
Authors: S Gerscher, JP Connelly, van Henegouwen Gmj Beinersbergen, AJ MacRobert, P Watt, Le. Rhodes
Journal: British Journal of Dermatology (2001)
Utility of serum free light chain measurements in multiple myeloma patients not achieving complete response to therapy
Authors: M Alhaj Moustafa, S V Rajkumar, A Dispenzieri, M A Gertz, M Q Lacy, F K Buadi, Y L Hwa, D Dingli, P Kapoor, S R Hayman, J A Lust, R A Kyle, S K Kumar
Journal: Leukemia (2015)
Repeated exposure to hair dye induces regulatory T cells in mice
Authors: I.M.C. Rubin, S. Dabelsteen, M.M. Nielsen, I.R. White, J.D. Johansen, C. Geisler, C.M. Bonefeld
Journal: British Journal of Dermatology (2010)

We have recently shown that commercial p-phenylenediamine (PPD)-containing hair dyes are potent immune activators that lead to severe contact hypersensitivity in an animal model. However, only a minority of people exposed to permanent hair dyes develops symptomatic contact hypersensitivity. This suggests that the majority of people exposed to hair dyes does not become sensitized or develop immunological tolerance.To study the immune response in mice repeatedly exposed to PPD-containing hair dye in a consumer-like manner.A commercial hair dye containing PPD was tested in C57BL/6 mice. The local immune response was measured by ear swelling and by histological examinations. The immune response in the draining lymph nodes was analysed by flow cytometry.The hair dye induced local inflammation as seen by swelling and cell infiltration of the treated ears. In addition, exposure to hair dye caused T-cell activation as seen by T-cell proliferation and production of interferon-γ and interleukin (IL)-17 within the draining lymph nodes. The inflammatory response peaked at the fourth exposure to hair dye. From this point on, an upregulation of regulatory T cells and IL-10-producing cells was seen.This study shows that PPD-containing hair dyes strongly affect the immune system. In addition to being potent skin sensitizers that activate inflammatory T cells, hair dyes also induce anti-inflammatory mechanisms. This might explain why many consumers can use hair dyes repeatedly without developing noticeable allergies, but it also raises the question whether the immune modulatory effects of hair dyes might influence the development of autoimmune diseases and cancers.
Abstract 20: Description of Dilutional Coagulopathy During Crystalloid Fluid Resuscitation in Hemorrhagic Shock
Authors: Alex St. John, Xu Wang, Esther Lim, Susan Stern, Nathan White
Journal: Circulation (2014)

Background: Coagulopathy is a deadly complication of hemorrhagic shock (HS). Current management of HS includes the administration of IV crystalloid, which may contribute to the development of a dilutional coagulopathy. This study characterizes the effect of crystalloid resuscitation on coagulation parameters in a model of uncontrolled HS. Methods: Immature female swine (26-35 kg, n=55) underwent 5 mm arteriotomy of the femoral artery, were allowed to bleed freely for either 30 or 45 seconds, followed by hemorrhage control with one of 7 mechanical interventions. Following attempted hemorrhage control, all animals received 15ml/kg of Hextend™, followed by either Lactated Ringers (LR) infused at 3ml/kg/min as needed for mean arterial pressure less than 60 mmHg or no further fluids. Animals were observed for 180 minutes. Regression models were used to evaluate the ability of infused crystalloid volume to predict thromboelastogram maximum amplitude (TEG MA), fibrinogen level (FBG), and platelet count (PLT) ove...
Understanding controlled trials: What is Zelen's design?
Authors: D. J Torgerson, M. Roland
Journal: BMJ (1998)

This is the fourth of an occasional series on the methods of randomised controlled trials

When patients do not receive their preferred treatment in randomised trials there may be difficulties with patient recruitment and scientific problems with bias.1 For example, bias may occur when patients are aware of a new treatment not available to them and comply poorly with the standard treatment.

Zelen's design can address these difficulties 2 3 by randomising patients before consent to participate has been sought. Two types of the design exist: double and single consent. In the double consent version patients are initially offered the treatment to which they were randomised; however, if they decline the randomised treatment, they can then be offered alternative therapies—including the experimental treatment. In …
Expanding the keratin mutation database: novel and recurrent mutations and genotype-phenotype correlations in 28 patients with epidermolytic ichthyosis
Authors: M.J. Arin, V. Oji, S. Emmert, I. Hausser, H. Traupe, T. Krieg, G. Grimberg
Journal: British Journal of Dermatology (2010)

Background Epidermolytic ichthyosis (EI) is a hereditary keratinization disorder caused by mutations in the keratin 1 (KRT1) or keratin 10 (KRT10) genes. In most cases of severe EI, heterozygous single point mutations are found at the highly conserved helix boundary motifs of KRT1 and KRT10 that play a critical role in filament formation. The presence of palmoplantar keratoderma suggests KRT1 mutations, whereas KRT10 mutations in most instances give rise to the nonpalmoplantar variants. Objectives To identify the underlying mutations in patients with EI and to correlate genotype and phenotype. Methods Mutation analysis was performed in 28 patients with EI by direct sequencing of KRT1 and KRT10 genes. Results We identified 14 different mutations, of which four have not been published previously. Conclusions Identification of novel mutations and genotype–phenotype correlations in EI allows improved understanding of disease pathogenesis as well as better patient management.
Abstract 14022: Implantable Cardioverter Defibrillator Does Not Impact Clinical Outcome in Left Ventricular Assist Device Patients
Authors: Valentina Kutyifa, Saadia Sherazi, David T Huang, Scott McNitt, Anna Papernov, Todd Massey, Leway Chen, Eugene Storozynsky, Wojciech Zareba, Jeffrey Alexis
Journal: Circulation (2014)

Background: The impact of implantable cardioverter defibrillator (ICD) on clinical outcome in patients with a continuous flow left ventricular assist device (LVAD) is not well understood. Hypothesis: We hypothesized that ICD would improve survival in LVAD patients. Methods: We evaluated the effect of an ICD on all-cause mortality in 172 patients with a HeartMate II LVAD implanted between May 2008 and November 2013 at the University of Rochester Medical Center, Rochester NY, enrolled in the Interagency Registry for Mechanically Assisted Circulatory Support (INTERMACS) Registry. The end point was all-cause mortality during the follow-up. Results: There were 113 of 172 (66%) LVAD patients with an ICD implanted before the LVAD implantation procedure, with a mean age of 56.9 ± 12.2 years, 15 of them were female. During the median follow-up of 25 months, 31 of 113 patients (27%) with an ICD died compared to 17 of 59 patients (29%) without an ICD. There was no significant difference in the cumulative probability...
Clinical Impact of Bleeding in Patients Taking Oral Anticoagulant Therapy for Venous Thromboembolism
Authors: Lori-Ann Linkins, Peter T. Choi, James D. Douketis
Journal: Annals of Internal Medicine (2003)

The authors found that anticoagulant-related major bleeding has a major impact in patients with venous thromboembolism, a factor that clinicians should take into account when deciding about long-te...
Abstract 3792: Upregulation of TNF-α by ethanol extract of Moringa oleifera leaves in benzene-induced leukemic Wister rat: a possible mechanism of anticancer property
Authors: Olufemi E. Akanni, Adebayo L. Adedeji, Kola J. Oloke
Journal: Cancer Research (2014)

Abstract Ethanol extract of Monringa oleifera leaves has been shown to possess anticancer properties in animal models. The mechanisms of action of its anticancer properties have not been fully demonstrated. In this study, we induced leukemia in two groups of 7 rats each by intravenous injection of benzene chromasolv solution (0.2 mL) 48 hourly for 4 weeks. The extract (0.2 ml of 100 mg/mL) was administered orally by gavage, after leukemia induction, daily for 4 weeks to one of the groups while the other group was not treated. The third group served as the normal control. At the end of the treatment, the rats were immobilized by cervical dislocation and blood samples were collected by cardiac puncture. Plasma concentrations of Beta-2 Microglobulins (β2M), Perforins (PF), Interleukin-2(IL2), Interferon-gamma (IFN-γ) and Tumour Necrosis Factor-alpha (TNF-α) were determined by standard commercial ELISA Results showed that leukemia was induced within 4 weeks as a significantly elevated leukocyte count and plasma β2M concentration over the baseline were noted (p&amp;lt; 0.05). Plasma IL2 and TNF-α were also significantly elevated while PF and IFN-γ decreased significantly in Moringa oleifera leaves extract treated rats compared with untreated groups. Since IL2 and PF are associated with cytotoxicity of CD8 T lymphocytes, reduced expression of PF in the face of increasing plasma concentration of IL-2 suggests that Moringa oleifera extract may not exert its anticancer properties via direct cytotoxicity. We thus concluded that increased expression TNF-α may translate to enhanced apoptosis and may be a possible mechanism of action. Citation Format: Olufemi E. Akanni, Adebayo L. Adedeji, Kola J. Oloke. Upregulation of TNF-α by ethanol extract of Moringa oleifera leaves in benzene-induced leukemic Wister rat: a possible mechanism of anticancer property. [abstract]. In: Proceedings of the 105th Annual Meeting of the American Association for Cancer Research; 2014 Apr 5-9; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2014;74(19 Suppl):Abstract nr 3792. doi:10.1158/1538-7445.AM2014-3792
A randomized investigation of high-dose versus standard-dose cytosine arabinoside with daunorubicin in patients with previously untreated acute myeloid leukemia: a Southwest Oncology Group study
Authors: JK Weick, KJ Kopecky, FR Appelbaum, DR Head, LL Kingsbury, SP Balcerzak, JN Bickers, HE Hynes, JL Welborn, SR Simon, M Grever
Journal: Blood (1996)