tbuckley/cabot-search huggingface dataset:
A PAINLESS HISTAMINE SKIN TEST: AN EXPERIMENTAL STUDY
Authors: Samuel Perlow
Journal: Annals of Internal Medicine (1933)

Article1 November 1933A PAINLESS HISTAMINE SKIN TEST: AN EXPERIMENTAL STUDYSAMUEL PERLOW, M.D.SAMUEL PERLOW, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-7-5-561 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptIn 1927 Thomas Lewis1demonstrated that the histamine skin reaction consisted of three distinct factors, (1) a local dilatation of the capillaries, venules, and arterioles by direct action which caused a purplish areola, (2) a local increase in the permeability of the walls of the minute vessels by direct action, which caused a wheal at the site of the injection, and (3) a widespread dilatation of the surrounding arterioles by local reflex action, which was visible as a red flare. He also demonstrated that if the circulation was cut off completely a purple spot would appear but no wheal or...Bibliography1. LEWIS T: The blood vessels of the human skin and their responses, 1927, Shaw and Sons, Ltd., London. LEWIS, T., and GRANT, R. T.: Vascular reactions of skin to injury; liberation of a histamine-like substance in injured skin; the underlying cause of factitious urticaria and of wheals produced by burning; and observations upon nervous control of certain skin reactions, Heart, 1924, xi, 209-265. Google Scholar2. STARR I: Change in reaction of skin to histamine as evidence of deficient circulation in lower extremities, Jr. Am. Med. Assoc., 1928, xc, 2092-2094. CrossrefGoogle Scholar3. DE TAKATS G: Cutaneous histamine reaction as test for collateral circulation in extremities, Arch. Int. Med., 1931, xlviii, 769-785. CrossrefGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Chicago, Illinois*Received for publication April 15, 1933.From the Peripheral Circulatory Clinic of the Michael Reese Hospital. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byZur diagnostischen Bedeutung der quantitativ erfa�ten Histaminreaktion bei einigen DermatosenThe temperature of the flare as an index of the intensity of the histamine skin reaction 1 November 1933Volume 7, Issue 5Page: 561-565KeywordsArteriolesCapillariesHistamineHospitalsReflexesSkin reactionSkin testsVenules ePublished: 1 December 2008 Issue Published: 1 November 1933 PDF downloadLoading ...
Effects of Mandatory Parental Notification on Adolescents' Use of Sexual Health Care ServicesStandards for Medical Expert TestimonyUpper Respiratory Tract Infections Among Airline PassengersRelationships Between Pharmaceutical and Tobacco CompaniesLimiting Residents' Work HoursGraves Disease in a US Army Special Forces Group
Authors: Peter F Cronholm, Ian M Bennett, Richard Neill
Journal: JAMA (2002)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Effects of auto-servo ventilation on cardiovascular function in patients with congestive heart failure and sleep-disordered breathing – A multicenter randomised controlled trial
Authors: Michael Artz, Frederic Series, Keir Lewis, Pierre Escourrou, Ruth Obermeier, Victoria Kehl, Michael Pfeifer
Journal: European Respiratory Journal (2011)

Background:  Auto-servo ventilation (ASV) has been shown to effectively suppress sleep-disordered breathing (SDB) in patients with congestive heart failure (CHF). However, the effects of ASV on cardiac function, daytime activity and quality of life are unclear (QOL).   Methods:  Patients with stable optimised CHF (Left ventricular ejection fraction (LVEF) ≤40%) and SDB (Apnoea-Hypopnoea Index (AHI) ≥20/hour) were randomised to either ASV (BiPAP ASV, Philips Respironics, n=37) or the control-group (n=35). LVEF (primary endpoint of the study, echocardiography), AHI (polysomnography scored in one core lab), B-type natriuretic peptide (NT-proBNP), daytime activity duration (actigraphy) and QOL (SF-36) were assessed at baseline and 3 months.   Results:  Significantly larger reduction in AHI was observed in the ASV-group (average daily ASV use was 4.47±2.93 hours/day) than in the control group (-39±16 vs. -1±13/hour, p   Conclusions:  ASV in CHF patients with SDB reduces NT-proBNP levels as a surrogate for improvement of cardiac function. Such changes were not associated with significant changes in LVEF. Patients on ASV improved their activity periods during the day and some domains of QOL.
Boosting Medicare Pay
Authors: Mike Mitka
Journal: JAMA (2005)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Electronic Devices and Applications to Track Physical Activity
Authors: Jennifer Schrack, Vadim Zipunnikov, Ciprian Crainiceanu
Journal: JAMA (2015)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Vaccines With Interleukin-12–Transduced Acute Myeloid Leukemia Cells Elicit Very Potent Therapeutic and Long-Lasting Protective Immunity
Authors: Kyriaki Dunussi-Joannopoulos, Kathlene Runyon, Jamie Erickson, Robert G. Schaub, Robert G. Hawley, John P. Leonard
Journal: Blood (1999)
Acute and 12-Month Results With Catheter-Based Mitral Valve Leaflet Repair
Authors: Patrick L. Whitlow, Ted Feldman, Wes R. Pedersen, D. Scott Lim, Robert Kipperman, Richard Smalling, Tanvir Bajwa, Howard C. Herrmann, John Lasala, James T. Maddux, Murat Tuzcu, Samir Kapadia, Alfredo Trento, Robert J. Siegel, Elyse Foster, Donald Glower, Laura Mauri, Saibal Kar
Journal: Journal of the American College of Cardiology (2012)
Diabetic Retinopathy Should Not Be a Contraindication to Thrombolytic Therapy for Acute Myocardial Infarction: Review of Ocular Hemorrhage Incidence and Location in the GUSTO-I Trial fn1fn1This study was supported by Bayer, New York, New York; CIBA-Corning, Medfield, Massachusetts; Genentech, South San Francisco, California; ICI Pharmaceuticals, Wilmington, Delaware; and Sanofi Pharmaceuticals, Paris, France.
Authors: Kenneth W. Mahaffey, Christopher B. Granger, Cynthia A. Toth, Harvey D. White, Amanda L. Stebbins, Gabriel I. Barbash, Alec Vahanian, Eric J. Topol, Robert M. Califf
Journal: Journal of the American College of Cardiology (1997)
DEPARTMENTS OF MEDICINE IN 1970. I. STAFF POLICIES
Authors: R H WILLIAMS
Journal: Annals of Internal Medicine (1959)

Medical Education1 May 1959DEPARTMENTS OF MEDICINE IN 1970. I. STAFF POLICIESROBERT H. WILLIAMS, M.D., F.A.C.P.ROBERT H. WILLIAMS, M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-50-5-1252 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptOptimal progress in medicine necessitates systematic planning for the distant as well as the immediate future. Many changes from some of our present patterns are indicated by (a) the tremendously rapid accumulation of medical knowledge, (b) the great improvement in medical facilities, (c) the rapidly increasing availability of good care for all subjects, made possible through improved communication, transportation and economic support, and (d) the public's as well as the scientists' keen interest in excellent medical care, research and teaching.In seeking information that might be helpful in formulating many future policies for departments of medicine, I recently composed a...Bibliography1. Williams RH: Future training in medicine and medical specialties, J. A. M. A. 167: 192, 1958. CrossrefMedlineGoogle Scholar2. Williams RH: Departments of medicine in 1970. II. Teaching policies, Ann. Int. Med., to be published. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Seattle, Washington*Received for publication May 12, 1958.From the Symposium on Whither Internal Medicine?, presented in summary at the Thirty-ninth Annual Session of The American College of Physicians, Atlantic City, New Jersey, May 1, 1958.From the Department of Medicine, University of Washington School of Medicine, Seattle, Washington.Requests for reprints should be addressed to Robert H. Williams, M.D., Professor and Executive Officer, Department of Medicine, University of Washington School of Medicine, Seattle 5, Washington.†Since the clinical situation at Harvard Medical School is divided, the head of the medical service at each of the four main hospitals was sent a questionnaire. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byReflections On The Past And Future Of Primary CareA history of the American Society for Clinical InvestigationThe Evolution of Departments of MedicineRheumatology - the ‘Cinderella’ specialty - an examination of doctors’ attitudes to training and careersDEPARTMENTS OF MEDICINE IN 1970. II. TEACHING POLICIES*ROBERT H. WILLIAMS, M.D., F.A.C.P. 1 May 1959Volume 50, Issue 5Page: 1252-1276KeywordsForecastingGastroenterology and hepatologyHealth services researchHematology and oncologyMedical servicesNutritionQuestionnairesScientists ePublished: 1 December 2008 Issue Published: 1 May 1959 PDF downloadLoading ...
Diagnostic accuracy of the new, virtual bronchoscopy based TBNA navigation system and EBUS-TBNA - A direct comparative study
Authors: Rafal Krenke, Piotr Korczynski, Joanna Domagala-Kulawik, Renata Langfort, Ryszarda Chazan
Journal: European Respiratory Journal (2013)

The aim of the study.  The study was aimed to evaluate the safety and diagnostic accuracy of the newly developed virtual bronchoscopy (VB) based TBNA navigation system as compared to standard EBUS-TBNA procedure.   Material and methods.  22 consecutive patients referred for diagnostic bronchoscopy due to mediastinal tumor or lymph node enlargement were enrolled. Segmentation of the airway and mediastinal targets and their spatial reconstruction was performed on site with an additional computer placed on the endoscopy trolley using standard thorax CT data. All patients underwent diagnostic bronchoscopy with VB guided TBNA (VB-TBNA) and EBUS-TBNA. Cytology was assessed by two independent pathologists.   Results.  40 nodal stations and 3 mediastinal tumors were sampled with both, VB-TBNA and EBUS-TBNA. The same number of the specific diagnoses was established by VB-TBNA and EBUS-TBNA (lung cancer in 15 pts, sarcoidosis in 2 pts and unknown cause in 5 pts). VB guided cytology and EBUS guided cytology were diagnostic in 21 and 23 mediastinal targets, respectively. Of the remaining, non-diagnostic cytology samples 11 collected with VB-TBNA and 12 collected with EBUS-TBNA contained adequate lymph node samples. No significant complications related to VB-TBNA and EBUS-TBNA procedures were noted.   Conclusions.  The diagnostic accuracy and safety of VB-TBNA in patients with mediastinal lymphadenopathy is similar to that showed by EBUS-TBNA. Further studies are warranted to evaluate the diagnostic accuracy of VB-TBNA in patients with different lymph node size and different underlying diseases.
Role of MTHFR polymorphisms as predictive markers of acute toxicity during 5-fluorouracil based chemotherapy for colorectal cancer: Preliminary data
Authors: V. Adamo, T. Franchina, B. Adamo, R. Briguglio, E. Restuccia, G. Chiofalo, G. Ferraro, D. Caccamo, R. Ientile
Journal: Journal of Clinical Oncology (2008)

15036 Background: Methylenetetrahydrofolate reductase (MTHFR) is a key enzyme in the folate metabolism pathway. Two common genetic polymorphisms (C677T and A1298C) are associated with reduced MTHFR activity. The aim of our study was to analyze the distribution of C677T and A1298C MTHFR gene polymorphisms in colorectal cancer (CRC) patients (pts), to evaluate their role as predictive markers of 5-FU toxicity in adjuvant chemotherapy. Methods: Genomic DNA was isolated from peripheral blood lymphocytes of 23 pts, using Puregene Genomic DNA Purification System. Pts (9 M/14 F) with histologically confirmed CRC, were treated with 5-FU containing adjuvant therapy. Median age was 61.5 (range 39–75). Genotyping for MTHFR polymorphism was carried out by DG-DGGE (double gradient-denaturing gradient gel electrophoresis). Results: The distribution of MTHFR T677 mutated allele in our population was 41.3%. Genotype frequencies were 47.8% for heterozygous CT677, 34.8% for the wild-type CC677 and 17.4% for the homozygous mutated TT677. The prevalence of MTHFR C1298 mutated allele was 28.3%, while genotype distribution was 56.5% for the wild-type AA1298, 30.4% for the heterozygous AC1298, and 13.1% for the homozygous mutated CC1298. The multivariate analysis for the combined polymorphisms showed that pts with double heterozygous genotype CT677/AC1298 were 21.7% in the sample population. The frequencies of other combined genotypes were 26.1% for CT677/AA1298 genotype, 17.4% for TT677/AA1298, 13.1% for both CC677/CC1298 and CC677/AA1298, and 8.7% for CC677/AC1298. We recorded severe G3-G4 toxicities after the initial administrations of chemotherapy in 3/4 pts with MTHFR genotype TT 677/AA1298 (G3 granulocytopenia and dyarrhea in 1/3 pts, G3 mucositis in 1/3 pts, and G3 thrombocytopenia in 1/3 pts). Mild toxicities were observed in pts having different genotypes. Conclusions: Our preliminary data show that the TT677 MTHFR genotype influences the development of 5-FU toxicity. Further studies will be carried out to evaluate the role of MTHFR polymorphisms as predictive markers of acute toxicity. DG-DGGE analysis used for MTHFR genotyping was proved to be a fast and reliable method helpful for pre- treatment screening. No significant financial relationships to disclose.
Abstract 17542: Diagnostic Efficacy of Instantaneous Wave-free Ratio (iFR), Resting Distal Coronary Artery Pressure / Aortic Pressure, and iFR During Adenosine Administration Among Intermediate Coronary Lesions
Authors: Kensuke Matsushita, Kiyoshi Hibi, Eiichi Akiyama, Keiko Takano, Nobuhiko Maejima, Noriaki Iwahashi, Kengo Tsukahara, Masami Kosuge, Toshiaki Ebina, Shinichi Sumida, Satoshi Umemura, Kazuo Kimura
Journal: Circulation (2014)

Background:  Fractional flow reserve (FFR) is an index of the severity of coronary stenosis that has been clinically validated in previous randomized trials. Instantaneous wave-free ratio (iFR) and resting distal coronary artery pressure / aortic pressure (Pd/Pa) are nonhyperemic pressure-derived indices of the severity of stenosis with discordant reports regarding their accuracy compared with FFR. This study sought to examine the correlation between FFR and other parameters including iFR, Pd/Pa and iFR during adenosine administration (iFRa).   Methods:  iFR, Pd/Pa, iFRa, and FFR were performed in 49 intermediate lesions in 43 patients. iFR and Pd/Pa were measured without hyperemia. iFRa and FFR were measured during maximal hyperemia using intravenous adenosine. We examined the correlation between FFR and each of iFR, Pd/Pa, and iFRa. Using the cut off value of 0.80 by FFR as a gold standard of ischemic threshold, the specific thresholds of iFR, Pd/Pa and iFRa were assessed.   Results:  Of 49 submitted lesions, 2 (4%) were excluded because of inadequate acquisition of pressure values, leaving 47 for final analysis. The correlation between FFR and iFR, Pd/Pa, and iFRa demonstrated an r of 0.71 (p   Conclusions:  iFR and Pd/Pa had less accuracy to predict myocardial ischemia as compared with iFRa, indicating that these pressure derived index without vasodilatation might be insufficient to assess coronary stenosis severity.
Abstract 4027: Traditional Chinese Medicine herbal mixture LQ prevents cyclophosphamide-induced metastasis and toxicity
Authors: Lei Zhang, Chengyu Wu, Lingna Li, Yong Zhang, Robert M. Hoffman
Journal: Cancer Research (2014)

Abstract Cyclophosphamide (CTX) can enhance metastasis (Cancer Res. 66, 303-306, 2006; Cancer Res. 68, 516-520, 2008) and has toxic side effects such as immune-suppression, weight loss, and hair loss. In the present study, the traditional Chinese medicine (TCM) herbal mixture LQ (J. Cell. Biochem. 114, 2131-2137, 2013) was tested to determine if it could enhance CTX efficacy and reduce side effects. HT1080 human fibrosarcoma cells, labeled with GFP in the nucleus and RFP in the cytoplasm, were injected into the epigastric cranialis vein of nude mice that were pre-treated with CTX and LQ. Lewis lung carcinoma (LLC)-RFP cells were injected into the tail vein of mice that were pre-treated with CTX and LQ. Efficacy was monitored with dynamic subcellular imaging of trafficking of cancer cells in blood vessels (Cancer Res. 68, 516-520, 2008) and imaging metastasis to the lung. LQ significantly reduced CTX-induced lung metastasis and cancer-cell adhesion to the inner wall of blood vessels. LQ also reduced kidney toxicity induced by CTX. Treatment with LQ induced hair growth after CTX administration. This result demonstrates that LQ provides safe and effective prevention of metastasis and toxicity in combination with chemotherapeutic agents such as CTX. Citation Format: Lei Zhang, Chengyu Wu, Lingna Li, Yong Zhang, Robert M. Hoffman. Traditional Chinese Medicine herbal mixture LQ prevents cyclophosphamide-induced metastasis and toxicity. [abstract]. In: Proceedings of the 105th Annual Meeting of the American Association for Cancer Research; 2014 Apr 5-9; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2014;74(19 Suppl):Abstract nr 4027. doi:10.1158/1538-7445.AM2014-4027
252. Phase II Study of MVA Expressing E6 and E7 of HPV16 in Patients with CIN2/3
Authors: Patrick Squiban, Patrice Mathevet, Bernard Huynh, Jean-Pai, Bory, Jean-Marc Balloul
Journal: Molecular Therapy (2004)

Objectives: TG4001 (MVA-HPV-IL2) is based on the Modified Virus of Ankara (MVA) strain expressing E6 and E7 of Human Papillomavirus type 16 (HPV16) and human Interleukin-2 (IL-2). The efficacy of two different doses was tested in a randomized, phase II trial, conducted in patients with high-grade Cervical Intraepithelial Neoplasia (CIN2/3) related to HPV16.
Lithium Protects Against Cartilage Degradation in Osteoarthritis
Authors: Takeshi Minashima, Ying Zhang, Youjin Lee, Thorsten Kirsch
Journal: Arthritis & Rheumatology (2014)

Objective To determine the actions of lithium chloride (LiCl) on catabolic events in human articular chondrocytes, and the effects of LiCl on the progression and severity of cartilage degradation in interleukin‐1β (IL‐1β)–treated mouse knee joints and after surgical induction of osteoarthritis (OA) in a mouse model. Methods Human articular chondrocytes were treated with LiCl followed by IL‐1β, and the expression levels of catabolic genes were determined by real‐time polymerase chain reaction. To understand the mechanism by which LiCl affects catabolic events in articular chondrocytes after IL‐1β treatment, the activation of NF‐κB was determined using luciferase reporter assays, and the activities of MAPKs and the STAT‐3 signaling pathway were determined by immunoblot analysis of total cell lysates. Cultures of mouse femoral head explants treated with IL‐1β and a mouse model of surgically induced OA were used to determine the effects of LiCl on proteoglycan loss and cartilage degradation. Results LiCl treatment resulted in decreased catabolic marker messenger RNA levels and activation of NF‐κB, p38 MAPK, and STAT‐3 signaling in IL‐1β–treated articular chondrocytes. Furthermore, LiCl directly inhibited IL‐6–stimulated activation of STAT‐3 signaling. Consequently, the loss of proteoglycan and severity of cartilage destruction in LiCl‐treated mouse knee joints 8 weeks after OA induction surgery or in LiCl‐treated mouse femoral head explants after IL‐1β treatment were markedly reduced compared to that in vehicle‐treated joints or explants. Conclusion LiCl reduced catabolic events in IL‐1β–treated human articular chondrocytes and attenuated the severity of cartilage destruction in IL‐1β–treated mouse femoral head explants and in the knee joints of mice with surgically induced OA, acting via inhibition of the activities of the NF‐κB, p38, and STAT‐3 signaling pathways.