tbuckley/cabot-search huggingface dataset:
Abstract P3-11-12: Vacuum assisted core-needle biopsy after neoadjuvant therapy in breast cancer to predict pathologic response
Authors: Regina Grosse, Jana Saegenschnitter, Thi-Dao Nguyen, Susanne Unverzagt, Joerg Buchmann, Eva J Kantelhardt, Nancy Papendick, Christoph Thomssen
Journal: Cancer Research (2015)

Abstract Introduction: Recently published neoadjuvant breast cancer therapy trials have documented impressive pathologic complete response (pCR) rates of up to 50% and above, depending on grade, hormone receptor and HER2 status and type of therapy. The purpose of our prospective study is to examine the predictive value of a standardized vacuum assisted core-needle biopsy (VAB) of the tumor site after neoadjuvant therapy with respect to pCR status. This is a presentation of the first case series of this single institution study. Methods: As of 2011, all patients who had completed neoadjuvant breast cancer therapy at our institution were informed about this trial regardless of their clinical response status. In case of consent, a mammography-guided VAB of the initially tagged tumor site was performed directly before the operation. In case of breast conserving surgery, mammographic wire localisation was performed immediately thereafter. Final surgery (breast conservation or mastectomy) was performed according to German guidelines. Ethical approval was obtained from the institutional review board. Pathologic complete response was defined as ypT0 ypN0. Results: Of 70 patients completing neoadjuvant therapy, 44 consented to the trial. The pCR rate was 47% (n=21). Pre-operative VAB correctly predicted residual disease in 19 of 23 cases (82,6%). We observed incorrect prediction of pathologic response if the tagging clip was not placed centrally, or if the radiologist did not perform the VAB in the tagged area. In 3 cases of pathologic partial response (pPR), all residual tumor (DCIS) was removed by VAB. In these cases, no further malignant lesions were detected in the resulting surgical specimens. Conclusions: Preliminary observations of this ongoing study are encouraging, although the correct prediction rate of residual disease is nowhere near the sensitivity needed to change clinical practice. However, if these results can be improved and confirmed in a larger series, it may be possible to reduce operative procedures after neoadjuvant therapy based on the results of a preoperative standardized VAB. Citation Format: Regina Grosse, Jana Saegenschnitter, Thi-Dao Nguyen, Susanne Unverzagt, Joerg Buchmann, Eva J Kantelhardt, Nancy Papendick, Christoph Thomssen. Vacuum assisted core-needle biopsy after neoadjuvant therapy in breast cancer to predict pathologic response [abstract]. In: Proceedings of the Thirty-Seventh Annual CTRC-AACR San Antonio Breast Cancer Symposium: 2014 Dec 9-13; San Antonio, TX. Philadelphia (PA): AACR; Cancer Res 2015;75(9 Suppl):Abstract nr P3-11-12.
Neuromorphology and Neuropharmacology of the Human Penis
Authors: George S. Benson, Joann McConnell, Larry I. Lipshultz, Joseph N. Corriere, Joe Wood
Journal: Journal of Clinical Investigation (1980)

The neuromorphology and neuropharmacology of the human penis are only briefly described in literature. The present study was undertaken to define the adrenergic and cholinergic neuromorphology of the human corpus cavernosum (CC) and corpus spongiosum and to evaluate the in vitro response of the CC to pharmacologic stimulation. Human penile tissue was obtained from six transsexual patients undergoing penectomy. For morphologic study, the tissue was processed for (a) hematoxylin and eosin staining; (b) smooth muscle staining; (c) acetylcholinesterase localization; (d) glyoxylic acid histofluorescence; (e) electron microscopy; and (f) electron microscopy after glutaraldehyde dichromate fixation. In addition, strips of CC were placed in in vitro muscle chambers and tension changes recorded isometrically after stimulation with norepinephrine (NE) and acetylcholine. The CC contains abundant smooth muscle, numerous glyoxylic acidfluorescent (catecholaminergic) fibers and varicosities, and a scant distribution of acetylcholinesterase-positive fibers. Fewer of all these elements were present in the corpus spongiosum. No "polsters" were observed in the CC. Although glutaraldehyde-fixed controls exhibited no typical adrenergic vesicles (small, dense core, measuring 400-600 Å in diameter), some small, strongly electron-dense vesicles were found in glutaraldehyde dichromate-fixed tissue and were thought to contain NE. A variety of other vesicles were also encountered. The addition of NE to the in vitro muscle chambers caused a dose-related contraction, which was blocked by pretreatment with phentolamine in all CC strips tested. Acetylcholine in high concentration produced minimal contraction in 2 of 24 strips. Our morphologic and pharmacologic data suggest that the sympathetic nervous system may affect erection by acting not only on the penile vasculature but also by direct action on the smooth muscle of the CC itself.
Abstract 12626: A Novel Drug-Coated Scoring Balloon for the Treatment of Coronary In-Stent Restenosis: One Year Results of the PATENT-C First-in-Human Trial
Authors: Bruno Scheller
Journal: Circulation (2014)

Introduction: Scoring balloons are useful in the acute treatment of in-stent restenosis, fibro-calcific and bifurcation lesions but have not been shown to affect the restenosis rate as compared to conventional balloons. Hypothesis: A novel paclitaxel-coated scoring balloon (SB) was developed to overcome these limitations. Prior studies in a coronary swine model demonstrated a marked reduction in restenosis using these SB and no evidence of local or systemic adverse effects. Methods: SB were coated with paclitaxel admixed with a specific excipient. Patients at 5 sites (4 in Germany and one in Brazil) with bare metal stent in-stent restenosis (ISR) were randomized 1:1 to treatment with either a drug-coated or bare SB. Baseline and 6-month follow-up quantitative coronary angiography was performed by an independent blinded core lab and all patients were evaluated clinically at 30 days, 6 and 12 months. The primary endpoint was angiographic in-segment late lumen loss (LLL). Secondary endpoints included clinica...
Abstract 2535: Diagnostic Accuracy of Renal Pressure Measurements to Assess the Significance of Renal Artery Stenosis: Comparison with Intravascular Ultrasound, Quantitative Angiography, and Duplex Ultrasound.
Authors: Massoud Leesar, Jai Varma, Adam Shapira, Ibrahim Fahsah, Sohail Ikram
Journal: Circulation (2007)
Abstract 3778: Glioblastoma multiforme utilizes system Xc- in survival under oxidative stress and chemoresistance
Authors: Rosyli F. Reveron, Monika D. Polewski, Karen S. Aboody
Journal: Cancer Research (2014)

Abstract Glioblastoma multiforme (GBM) is the most common and aggressive malignant primary brain tumor in humans, with a median survival rate of 10-15 months and a five year survival rate of 2.9% from initial diagnosis. Characteristically, GBM exhibits high proliferation and metabolism rates as well as low reactive oxygen species (ROS) production that is sustained using a sodium-independent, electro-neutral transporter known as system XC-. System XC- is composed of a regulatory heavy subunit (4F2hc) linked to a catalytic light subunit (xCT). This protein complex mediates the uptake of L-cystine into the cell, and L-glutamate out of the cell, at a 1:1 ratio. Imported cystine is reduced to L- cysteine, the rate limiting substrate in glutathione (GSH) synthesis. Glutathione is an essential antioxidant in the central nervous system that is responsible for maintaining intracellular redox homeostasis by neutralizing ROS. High intracellular GSH levels in cancer cells are associated with drug resistance and detoxification of alkylating agents such as temozolomide (TMZ). Therefore, system XC- expressed in glioma cells may be used as a target to reduce glioma survival and tumor burden. Sulfasalazine inhibits system Xc- and demonstrated a strong antitumor potential in preclinical models of malignant glioma. However, the first clinical trial using sulfasalazine to treat GBM patients was terminated due to off-target effects. To further elucidate the protective role of system XC- in GBM, we generated stable xCT knock-down and over-expressing U251 glioma cells. These lines were characterized for survival, proliferation, apoptosis and resistance to insult. The xCT-over-expressing cells were more resistant to hydrogen peroxide treatment and GSH depletion. Interestingly, over-expression of system XC- in U251 cells also resulted in decreased sensitivity to TMZ treatment compared to parental and empty vector controls. As expected, xCT-knock-down cells exhibited increased intracellular ROS after treatment. Using glioma lines stably transduced to over-express or knock-down xCT, we demonstrate for the first time that system XC- over-expression in GBM not only promotes survival under oxidative stress but may also modulate sensitivity to chemotherapy treatment. Therefore, therapeutic manipulation of this transporter either alone or in combination with other treatments may improve clinical outcome in patients diagnosed with GBM. Citation Format: Rosyli F. Reveron, Monika D. Polewski, Karen S. Aboody. Glioblastoma multiforme utilizes system Xc- in survival under oxidative stress and chemoresistance. [abstract]. In: Proceedings of the 105th Annual Meeting of the American Association for Cancer Research; 2014 Apr 5-9; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2014;74(19 Suppl):Abstract nr 3778. doi:10.1158/1538-7445.AM2014-3778
多病并存的多重挑战——这个时代已经到来——关注日益增长的脆弱人群的需求
Authors: 赛晓勇（译）, 何耀（校）
Journal: BMJ (2007)

多病并存（或称多重病）现象在初级卫生保健中已不是个别现象。最近在加拿大魁北克省沙格奈河地区进行的一项有21个社区医院参加的研究表明，在18～44岁组多重病的患病率为69％，45～64岁组为93％，65岁以上组达到98％，患慢性病的个数在年轻组为2．8而在老年组升至6．4。其他国家也报告了类似的疾病负担状况，如美国多病并存的患者人数将由2000年的6000万上升到2020年的8100万。
Cross border health care in Europe
Authors: P. Kanavos, M. McKee, T. Richards
Journal: BMJ (1999)

It's been an eventful year for the European Union. The resignation of the European Commission may have been a debacle, but January saw the launch of the Euro, and the new Treaty of Amsterdam is on its way to ratification by national parliaments. Both events will have an impact on medicine. A common currency will highlight the disparity in levels of healthcare costs and expenditure across the member states. The new treaty, which paves the way for enlarging the union, will, among other things, fuel the free movement of health-care professionals, especially from east to west Europe. Meanwhile the impact of European Union legislation continues to grow, from the 48 hour working time directive to the directive enshrining mutual recognition of professional qualifications which is spurring harmonisation of professional training.

Healthcare shopping in the union may not yet be commonplace, but last year's landmark European Court rulings coupled with the price transparency that the Euro will bring will give it …
Abstract 15774: Impaired Autophagy Contributes to Toll Like Receptor-4 Induced Osteogenesis in Human Aortic Valve Interstitial Cells
Authors: Xinsheng Deng, Xianzhong Meng, David Fullerton, James Jaggers
Journal: Circulation (2014)

Objective:  Stimulation of Toll-like receptor 4 (TLR4) induces inflammatory and osteogenic responses in aortic valve interstitial cells (AVICs). Autophagy protects against vascular calcification. We therefore hypothesized that LPS impairs autophagy, and this contributes to osteogenesis in human AVICs via mTOR signaling.   Methods:  AVICs were isolated from the adult explanted heart transplant recipients without aortic valve abnormalities. Cells were treated with LPS. Autophagy activity was investigated using chemical inhibitors and genetic techniques. The osteogenic markers bone morphogenetic protein 2 (BMP-2) and alkaline phosphatase (ALP), as well as mTOR associated signaling molecules, were analyzed.   Results:  LPS inhibited autophagy as indicated by changes of protein levels of LC3-II. Suppression of autophagy by 3-methyladenine, bafilomycin, or short hairpin-mediated silencing of Becn1 gene increased the expression of BMP-2 and ALP. Conversely, upregulation of autophagy with rapamycin or overexpression of Becn1 decreased the levels of BMP-2 and ALP in response to LPS and decreased ALP activity and calcium nodule formation. Mechanistically, inhibition of autophagy was mediated at least partly by increased mTOR signaling.   Conclusions:  LPS suppressed autophagy and induced mTOR-mediated osteogenic responses in human AVICs. The results suggest that autophagy regulates inflammation-induced osteogenic responses in human AVICs. Inhibition of mTOR by rapamycin may have a therapeutic implication for initiation and progression of calcific aortic valve disease.
WHO Survey of Prevalence of Mental Health Disorders—Reply
Authors: Ronald C. Kessler, T. Bedirhan Ustun
Journal: JAMA (2004)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Calculating the end-systolic pressure-volume relation.
Authors: A J Crottogini, P Willshaw
Journal: Circulation (1991)

Administration of Endothelin-1 in HumansVierhapper, Wagner, Nowotny, and Waldhiusl recently reported the first study involving systemic administration of endothelin-1 in humans.1 Intravenous infusion of endothelin-1 at a maximum dose (5.0 ng/kgmin) sufficient to increase plasma immunoreactive endothelin from 1.2+0.3 to 56.5+±50.3pmol/l led
Epidemiology of Asthma in Children with Particular Reference to Wind Speed and Wind Direction
Authors: G R NEWELL, L I SWAFFORD
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
High prevalence of azithromycin resistance to Treponema pallidum in geographically different areas in China
Authors: X.-S. Chen, Y.-P. Yin, W.-H. Wei, H.-C. Wang, R.-R. Peng, H.-P. Zheng, J.-P. Zhang, B.-Y. Zhu, Q.-Z. Liu, S.-J. Huang
Journal: Clinical Microbiology and Infection (2012)
A Text-Book of Clinical Neurology.
Authors: Eric J. Sorenson
Journal: JAMA (1933)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue Archives of Neurology & Psychiatry HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Facial Plastic Surgery JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the Archives of Neurology & Psychiatry journal
Coronary Artery Bypass Grafting in Patients With Low Ejection Fraction
Authors: Veli K. Topkara, Faisal H. Cheema, Satish Kesavaramanujam, Michelle L. Mercando, Ayesha F. Cheema, Pearila B. Namerow, Michael Argenziano, Yoshifumi Naka, Mehmet C. Oz, Barry C. Esrig
Journal: Circulation (2005)

Patients with low ejection fraction (EF) are at a higher risk for postoperative complications and mortality. Our objective was to assess the effect of low EF on clinical outcomes after coronary artery bypass grafting (CABG).We analyzed 55,515 patients from New York State database who underwent CABG between 1997 and 1999. Patients were stratified into 1 of the 4 EF groups: Group I (EF< or =20%), Group II (EF 21% to 30%), Group III (EF 31% to 40%), and Group IV (EF>40%). History of previous myocardial infarction, renal failure, and congestive heart failure were higher in patients with low EF (all P<0.001). Group I experienced a higher incidence of postoperative respiratory failure (10.1% versus 2.9%), renal failure (2.5% versus 0.6%), and sepsis (2.5% versus 0.6%) compared with Group IV. In-hospital mortality was significantly higher in Group I (6.5% versus 1.4%; P<0.001). Multivariate analysis showed hepatic failure [odds ratio (OR), 11.2], renal failure (OR, 4.1), previous myocardial infarction (OR, 3.4), reoperation (OR, 3.4), emergent procedures (OR, 3.2), female gender (OR, 1.7), congestive heart failure (OR, 1.6), and age (OR, 1.04) as independent predictors of in-hospital mortality in the low EF group. The discharges to home rate were significantly lower in Group I versus Group IV (73.1% and 87.7%, respectively; P<0.001).Patients with low EF are sicker at baseline and have >4 times higher mortality than patients with high EF. However, outcomes are improving over time and are superior to historical data. Therefore, CABG remains a viable option in selected patients with low EF.
Cardiorespiratory variables of preterm infants near term
Authors: Arun Kumar Pugalenthi, Chloe Parsley, Peter Gray, Kartik Iyer, Sadasivam Suresh
Journal: European Respiratory Journal (2011)

Introduction:  Significant advances in neonatal care have improved survival in preterm infants. However chronic neonatal lung disease (CNLD) continues to be a significant problem. There is very limited data in literature describing the cardiorespiratory variables at 35-36 weeks of infants who are born preterm.   Aim:  To collect sleep pattern and normative cardiorespiratory data in preterm infants born under 31 week9s gestation at corrected gestation of 35-36 weeks. (We present the cardiorespiratory data).   Methods:  Using an in-house polysomnography system prospective data on respiratory effort using effort bands, pulse oximetry, actigraphy and visual scoring of sleep using video camera were collected in a cohort of preterm infants under 31 weeks gestation over a 6-10 hour period continuously. We analyzed the heart rate, oxygen saturations from the data collected on the pulse oximetry channel. The respiratory rate was derived using the Labchart software. We are presenting heart rate, oxyhaemoglobin saturation and respiratory rate profile on 25 preterm infants.   Results:  The mean heart rate with 5,95th centiles was 155 (129-181). The mean oxyhaemoglobin saturation with 5, 95th centiles was 94.7 (85.9-98.8). The respiratory rate had significant variability between awake and sleep with the range between 34-100/min. The average respiratory rate was in the 50s for this group of infants. Cumulative frequency curves constructed with the heart rate and oxyhaemoglobin data provides us with reference ranges for this specific group of preterm infants.   Conclusion:  The description of reference ranges for cardiorespiratory variables would provide us with objective data in management of CNLD infants and ascertaining home oxygen requirement.