tbuckley/cabot-search huggingface dataset:
THERAPY OF TRAUMATIC SHOCK
Authors: B BURBANK
Journal: Annals of Internal Medicine (1951)

Article1 October 1951THERAPY OF TRAUMATIC SHOCKBENJAMIN BURBANK, M.D., F.A.C.P.BENJAMIN BURBANK, M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-35-4-857 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe experiences of the past war have shown how very difficult it is to define by exact criteria just what constitutes the condition of shock. The end stage, in which the patient has no perceptible blood pressure or pulse, is pale with a gray cyanosis and cold with clammy perspiration, represents a medical defeat in diagnosis. Attempts to delineate a definite blood pressure level, such as 70 mm. Hg, have serious drawbacks because the end stage as described above may take place within a matter of minutes after such a reading. The same objections hold true for determining the...Bibliography1. Blalock A: Principles of surgical care; shock and other problems, 1940, C. V. Mosby Co., St. Louis. Google Scholar2. Moon VH: Shock and related capillary phenomena, 1938, Oxford University Press, New York. Google Scholar3. BurfordBurbank THB: Traumatic wet lung, J. Thoracic Surg. 14: 6 (Dec.) 1945. CrossrefGoogle Scholar4. BrewerBurbankSamsonSchiff LABPCCA: The wet lung in war casualties, Ann. Surg. 123: 343 (March), 1946. CrossrefGoogle Scholar5. JawetzSpeck ERS: Joint action of penicillin and chloramphenicol on an experimental streptococcic infection of mice, Proc. Soc. Exper. Biol. and Med. 74: 93-96, 1950. CrossrefMedlineGoogle Scholar6. Beecher HK: Morphine poisoning in battle casualties, Medical Bulletin, NATOUSA 1: 22 (Feb.) 1944. Google Scholar7. Dry J: Personal communication. Google Scholar8. FitzpatrickAdamsBurbank LJAJB: Nerve block in the treatment of thoracic injuries, Medical Bulletin, NATOUSA 2: 51-53 (Sept.) 1944. Google Scholar9. SamsonBrewerBurbank PCLAB: Tracheobronchial catheter aspiration, Bull. U. S. Army M. Dept. 5: 227 (Feb.) 1946. MedlineGoogle Scholar10. Hadfield G: Differential diagnosis of lung injuries, Lancet 2: 197-199 (Aug. 16) 1941. Google Scholar11. Zuckerman S: Discussion on problems of blast injuries, Proc. Roy. Soc. Med. 34: 171-192 (Jan. 6) 1941. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Brooklyn, New York*Received for publication February 7, 1951.From the Department of Medicine, State University Medical Center at New York, College of Medicine, and the Long Island College Hospital, Brooklyn, New York. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 October 1951Volume 35, Issue 4Page: 857-871KeywordsBlood pressureHeart rateHospital medicineShockSweat ePublished: 1 December 2008 Issue Published: 1 October 1951 PDF downloadLoading ...
Early Invasive Therapy in Non-ST-elevation Myocardial Infarction Improves Survival Although Benefit Declines with Worsening Renal Function - Data from the Register of Information and Knowledge About Swedish Heart Intensive Care Admissions (RIKS-HIA)
Authors: Karolina Szummer, Pia Lundman, Stefan Jacobson, Staffan Schon, Johan Lindback, Ulf Stenestrand, Lars Wallentin, Tomas Jemberg
Journal: Circulation (2008)

Early Invasive Therapy in Non-ST-elevation Myocardial Infarction Improves Survival Although Benefit Declines with Worsening Renal Function - Data from the Register of Information and Knowledge About Swedish Heart Intensive Care Admissions (RIKS-HIA)
Brief Report: Expression of Interferon‐γ Receptor Genes in Peripheral Blood Mononuclear Cells Is Associated With Rheumatoid Arthritis and Its Radiographic Severity in African Americans
Authors: Qi Tang, Maria I. Danila, Xiangqin Cui, Lauren Parks, Brandi J. Baker, Richard J. Reynolds, Chander Raman, Keith C. Wanseck, David T. Redden, Martin R. Johnson, S. Louis Bridges
Journal: Arthritis & Rheumatology (2015)

The factors responsible for radiographic severity in African American patients with rheumatoid arthritis (RA) are poorly understood. We sought to identify genes whose expression in peripheral blood mononuclear cells is associated with radiographic severity in RA.In the first phase of the study, we performed real-time quantitative polymerase chain reaction to analyze the expression of 182 candidate genes in 40 African American RA patients with extremes of radiographic damage (low versus high radiographic scores) and disease duration (≤2 years versus >2 years) and 20 healthy African American control subjects; the genes were selected based on plausible immune pathways. In the second phase, we analyzed the expression of the genes that were shown to be significantly associated with radiographic scores in 576 African American patients with RA and 51 African American control subjects who had not been studied previously, accounting for autoantibody status and disease duration.We observed significant differences in IFNGR1 expression between patients with RA and control subjects (adjusted P [P(adj)] = 6 × 10(-14)) and in IFNGR2 expression between RA patients with erosions and those with no erosions (P(adj) = 0.01 by Wilcoxon's rank sum test). We also observed significant correlations between IFNGR2 expression and radiographic scores (P(adj) = 0.03 for erosions, P(adj) = 0.04 for joint space narrowing, and P(adj) = 0.03 for total radiographic score [zero-inflated negative binomial regression model]) and annualized progression rate (P(adj) = 0.0024 by Spearman's correlation analysis).These findings have important implications with respect to the role of interferon-γ (IFNγ) in the pathogenesis of RA and may lead to identification of a biomarker for radiographic damage. Additional studies are needed to define the cell subsets responsible for the association of IFNγ receptor gene expression with radiographic findings, which downstream mechanisms are involved, and generalizability to other RA populations.
Red meat allergic patients have a selective IgE response to the α-Gal glycan
Authors: D. Apostolovic, T. A. T. Tran, S. Sánchez-Vidaurre, T. Cirkovic Velickovic, M. Starkhammar, C. Hamsten, M. van Hage
Journal: Allergy (2015)

Galactose-α-1,3-galactose (α-Gal) is a mammalian carbohydrate with significance in a novel type of food allergy. Patients with IgE against α-Gal report severe allergic symptoms 3-6 h after consumption of red meat. We investigated whether IgE from red meat allergic patients recognizes other mammalian glycans than α-Gal or glycans from the plant kingdom and insects of importance in allergy. We found that none of the 24 red meat allergic patients investigated had an IgE antibody response against the other abundant mammalian glycan N-glycolylneuraminic acid or against cross-reactive carbohydrate determinants from plant or venom sources (nCup a 1, nArt v 1, and MUXF3). Deglycosylation of an α-Gal-containing protein, bovine thyroglobulin, significantly reduced the IgE response. In conclusion, we show that red meat allergic patients have a selective IgE response to the α-Gal glycan found in red meat. Other common glycans reactive in allergic disease are not targets of red meat allergic patients' IgE.
BACTEROIDES INFECTIONS: REPORT OF TWO CASES UNSUCCESSFULLY TREATED WITH ANTIBIOTICS
Authors: A B KING, S D CONKLIN, T S COLLETTE
Journal: Annals of Internal Medicine (1952)

Case Reports1 October 1952BACTEROIDES INFECTIONS: REPORT OF TWO CASES UNSUCCESSFULLY TREATED WITH ANTIBIOTICSA. B. KING, M.D., S. D. CONKLIN, M.D., F.A.C.P., T. S. COLLETTE, B.A.A. B. KING, M.D.Search for more papers by this author, S. D. CONKLIN, M.D., F.A.C.P.Search for more papers by this author, T. S. COLLETTE, B.A.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-37-4-761 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptInfections with organisms of the genus Bacteroides have long been known in veterinary medicine and have been sporadically reported through the past five decades. Their importance as infectious agents in man has been recognized increasingly as more adequate methods of anaerobic investigation have been utilized, although the experience of any group of physicians has generally been limited to a few cases.These organisms are commonly found on the mucous membranes of the body from whence they may invade the tissues, blood or body cavities. Metastatic abscesses often are formed when septicemia occurs. Necrosis of tissue at the primary focal lesion,...Bibliography1. BeigelmanRantz PMLA: Clinical significance of Bacteroides, Arch. Int. Med. 84: 605-631, 1949. CrossrefGoogle Scholar2. BrownWilliamsHerrell AEHLWE: Bacteroides septicemia; report of a case with recovery, J. A. M. A. 116: 402-404, 1941. CrossrefGoogle Scholar3. BuhlerSeelyDixon VBCWDD: Bacterium necrophorus septicemia in man, Am. J. Clin. Path. 12: 380-386, 1942. CrossrefGoogle Scholar4. McVayGuthrieSprunt LWFDH: Septicemia due to Bacteroides; aureomycin hydrochloride therapy in 2 cases due to Bacteroides funduliformis , J. A. M. A. 140: 1150-1152, 1949. CrossrefMedlineGoogle Scholar5. SmithRopes WEMW: Bacteroides infections; analysis based on review of literature and study of 20 cases, New England J. Med. 232: 31-37, 1945. CrossrefGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Sayre, Pennsylvania*Received for publication March 3, 1952.From the Departments of Neurosurgery, Medicine and Bacteriology at the Guthrie Clinic and Robert Packer Hospital. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byEvolution of Anaerobe Susceptibility Testing in the United StatesCervicofacial LeptotrichosisBacteroides Infection in the Surgery of Childhood 1 October 1952Volume 37, Issue 4Page: 761-767KeywordsAntibioticsBacteriologyBacteroidesBloodHospital medicineLesionsMucous membranesNecrosisNeurosurgerySepsis ePublished: 1 December 2008 Issue Published: 1 October 1952 PDF downloadLoading ...
Abstract 15083: Early Spontaneous Vagal Reflexes Reduce the Inflammatory Response in Patients with Myocardial Infarction Treated with Primary Percutaneous Coronary Intervention
Authors: Alice Ravera, Angela Lesce, Rita Camporotondo, Maurizio Ferrario, Alessandra Repetto, Andrea Demarchi, Riccardo Albertini, Gaetano M De Ferrari
Journal: Circulation (2014)

BACKGROUND:  Depressed vagal activity -assessed 4 weeks after myocardial infarction (MI) - is a independent predictor of cardiac mortality in patients with an ST elevation myocardial infarction (STEMI). Recently, the “cholinergic anti-inflammatory pathway” has been described: vagal activity can inhibit the release of pro-inflammatory cytokines (CK) such as interleukin-6 (IL6), without influencing the anti-inflammatory CK. IL6 exerts unfavorable effects and is involved in no-reflow pathophysiology, since it triggers neutrophil chemotaxis after myocardial ischemia-reperfusion (I/R). In fact, several studies have demonstrated that vagal stimulation can reduce inflammatory response, infarct size and no-reflow in animal models of myocardial I/R. The relationship between vagal activity and inflammatory response in STEMI has never been assessed.   AIM:  We assessed the relationship between vagal activity and IL6 concentrations (IL6c) in patients during the first hours after a STEMI treated with primary percutaneous coronary intervention (PCI).   METHODS:  We enrolled 29 patients with STEMI undergoing primary PCI. We evaluated vagal activity by calculating baroreflex sensitivity (BRS) with sequence method from spontaneous rate-pressure recordings 1 (BRS1h)-3 (BRS3h)-6-12 and 24 hours (h) after PCI. We determined IL6c with immunometric assay on serum samples collected before and 6-12-24-36h after PCI. IL6 and BRS values were log-normalized.   RESULTS:  We found a significant negative correlation between BRS1h and IL6c 6h after PCI (R= -0.52, p=0.004). The correlation between BRS1h and IL6c progressively declined at12h (R= -0.481, p=0.008) and 24h (R= -0.424, p=0.022);it was lost at 36h after PCI. BRS3h showed a similar correlation with IL6c 6h after PCI (R= -0.478, p=0.009), but no significant correlation with IL6c 12h, 24h and 36h after PCI. BRS values calculated after the 3rd h showed no significant correlation with any of the IL6c. IL6c before PCI were not correlated with any of the BRS values.   CONCLUSIONS:  Patients with higher BRS values after myocardial infarction/reperfusion showed lower levels of serum IL6. This study provides the first evidence suggesting an anti-inflammatory effect of vagal activity during myocardial infarction in man.
Abstract 16123: 80 % of the Patients Have a Headache During Balloon Cryoablation
Authors: Laurent Pison, Pim Peeters, Yuri Blaauw, Suzanne Philippens, Harry J. Crijns, Johan Vlaeyen, Jean Schoenen, Carl Timmermans
Journal: Circulation (2011)

Purpose Although point-by-point cryoablation (cryo) is known to result in nearly no application-related pain, recent studies reported headache during balloon cryo. The purpose of this study was to ...
Abstract 19863: Impact of Coronary Artery Fixed Lesion on 3-years Clinical Outcomes in Vasospastic Angina Patients with Myocardial Bridge
Authors: Seung Woon Rha, Se-Whan Lee, Won-Yong Shin, Seung-Jin Lee, Dong-Kyu Jin, Byoung Geol Choi, Se Yeon Choi, Sunki Lee, Ji Bak Kim, Jin Oh Na, Cheol Ung Choi, Hong Euy Lim, Jin Won Kim, Eung Ju Kim, Chang Gyu Park, Hong Seog Seo, Dong Joo Oh
Journal: Circulation (2014)

Background: It is not known whether the presence of angiographic fixed coronary lesion (FCL) can negatively impact on long-term major clinical outcomes in vasospastic angina patients (pts) with myocardial bridge (MB). Methods: A total 5,882 patients (pts) underwent coronary angiography with acetylcholine (Ach) provocation test from Nov 2004 to Oct 2010. Among them, total 563 pts who had MB and documented significant coronary artery spasm (CAS) by Ach provocation test were enrolled. Study populations were categorized into two groups; the fixed coronary lesion (FCL) group (n=216) and the non-FCL group (n=347). Cumulative major clinical outcomes were compared between the two groups up to 3 years. Results: Baseline characteristics were similar between the two groups except the incidence of elderly, hypertension, diabetes, and dyslipidemia were higher in the FCL group. In univariate analysis, only the composite end-point consisted of cardiac death, de Novo percutaneous coronary intervention (PCI), myocardial infarction (MI), and cerebrovascular accident (CVA) was higher in FCL group (Table). However, in multivariate regression analysis, the incidences of cardiac death, PCI, MI, CVA, recurrent chest pain, and other composite end-points were similar between the two groups up to 3 years. Conclusions: In our study, the presence of angiographic fixed coronary lesion in vasospastic angina pts with MB was not a predictor of adverse long-term clinical outcomes.
Abstract P302: Association of High-Sensitive Troponin I With Coronary Heart Disease Incidence Among Asymptomatic Older Adults: The ADVANCE Study
Authors: Carlos Iribarren, Malini Chandra, Jamal S Rana, Mark A Hlatky, Stephen P Fortmann, Thomas Quertermous, Alan S Go
Journal: Circulation (2015)

Background: The third generation of cardiac troponin-I assays (high-sensitive troponin-I, hs-TI) has a lower limit of detection one order of magnitude lower than current commercial assays. Elevated hs-TI has been associated with structural and coronary heart disease (CHD), but data remains sparse, particularly in asymptomatic subjects free of clinical cardiovascular disease (CVD). Methods: Among asymptomatic subjects with no known CVD in The Atherosclerotic Disease, VAscular FunctioN and GenetiC Epidemiology (ADVANCE) Study recruited in 2002-04 (mean ± SD age=62 ± 8 years, 49% women; 52% non-white), we identified the correlates of hs-TI and the independent predictive value of hs-TI for incident CHD (hospitalization or death with ICD9 codes 410-414 or coronary revascularization procedures) over a median of 8 years of follow-up. Hs-TI was measured using stored serum with the Abbott ARCHITECT STAT assay, a chemiluminescent microparticle immunoassay (CMIA). Results: There were 153 CHD events among 1,157 subjects. The median (interquartile range, in ng/L) of hs-TI was 4.1 (3.1-5.5) in men and 3.3 (2.5-4.2) in women. The independent (positive) correlates of hs-TI were black race, body mass index, diabetes and hypertension. Age-adjusted CHD rates showed a threshold effect at the 4 th quartile. In proportional hazards regression, there was a 2.4-fold increased risk of CHD associated with the sex-specific quartile IV (relative to quartiles I-III combined) in Model 1 adjusting for age, gender and race/ethnicity. The increased risk was only partially explained by adjustment for Framingham risk score (FRS), C-reactive protein and estimated glomerular filtration rate (Model 2). The area under the curve (AUC) improved from 0.66 to 0.69 (p=0.05) after adding hs-TI to a model with Model 2 covariates, and the net reclassification improvement (NRI) was 0.13 (p=0.01). Conclusion: Among asymptomatic adults without known CVD, hs-TI may be useful for helping identify patients at increased CHD risk beyond traditional risk factors.
Transepidermal elimination of urate-like crystals: a new perforating disorder?
Authors: None Lucke, None Fallowfield, None Evans, None Lowe, None Mackie
Journal: British Journal of Dermatology (1999)

We report two men who developed a transient perforating disorder characterized by transepidermal elimination of negatively birefringent needle-shaped crystals similar to monosodium urate. This striking clinical presentation has not previously been described and we propose that it be added to the group of diseases known as the primary perforating disorders.
WILLIAM WITHERING: HIS CONTRIBUTION TO MEDICINE
Authors: Jonathan C. Meakins
Journal: Annals of Internal Medicine (1942)

Article1 February 1942WILLIAM WITHERING: HIS CONTRIBUTION TO MEDICINEJONATHAN C. MEAKINS, F.A.C.P.JONATHAN C. MEAKINS, F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-16-2-327 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptOn March 17 of the year 1741, two hundred years ago, there was born at Wellington, in Shropshire, to Edmund Withering and his wife, Sarah Hector, a son who was to be known as William. The event was not heralded by any celestial phenomena or terrestrial disturbances.Our scene really opens in the latter half of the century, a period of intellectual, scientific and political unrest and consequent progress. The seeds of independence and freedom of man were in the state of germination. The writings of Rousseau and Hume were influencing men's political outlook. The American revolution against traditional privilege... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Montreal, Quebec,*Read at the Boston meeting of the American College of Physicians April 22, 1941. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 February 1942Volume 16, Issue 2Page: 327-332 Issue Published: 1 February 1942 PDF downloadLoading ...
Abstract P090: Change in Visceral Adipose Tissue and Change in Cardiometabolic Risk in a Minority Cohort: The IRAS Family Study
Authors: Kristen G Hairston, Janet A Tooze, Andrea Anderson, Jill M Norris, Jerome I Rotter, Ida Y Chen, Lynne E Wagenknecht
Journal: Circulation (2014)

Visceral adipose tissue (VAT), the more metabolically harmful fat depot, has been associated with a higher prevalence of diabetes, insulin resistance, and impaired glucose homeostasis. Higher levels of VAT are associated cross-sectionally with cardiovascular (CV) risk factors, specifically hypertension and unfavorable lipid profiles. Research on the effects of change in VAT on CV risk factors is extremely limited and no studies have explored these questions in minority cohorts. The Insulin Resistance Atherosclerosis Family (IRAS Family) Study offered the opportunity to explore whether changes in VAT were associated with changes in CV risk, independent of changes in BMI, in a minority cohort. Abdominal computed tomography (CT) scans were obtained at two time points spanning a five year interval among African-American (N=295) and Hispanic-American participants (N=719), aged 18-65 years. The CV risk factors included 5-year change in insulin resistance (HOMA), high density lipoprotein (HDL) cholesterol and systolic blood pressure (SBP). To account for family structure, we used mixed models stratified by gender to estimate change in CV risk factors as a function of change in VAT, adjusted for change in BMI, age category, race, physical activity level, smoking status, statin use (for HDL) and antihypertensive use (for SBP). The cohort was 62% female, with an overall mean age of 40 years at baseline. The mean (SD) changes in BMI and VAT over 5-years were 1.1 (2.6) kg/m 2 and 4.2 (31.0) cm 2 , respectively; the mean (SD) changes in HOMA, HDL, and SBP over 5 years were 1.3 units (2.8), 4.8 (9.3) mg/dL and 2.4 (12.7) mm Hg, respectively. On average, a one standard deviation increase in VAT (31 cm 2 ) was significantly associated with a 0.58 unit increase in HOMA in men (p&lt;0.0001) and 0.42 unit increase in women (p=0.0048) in the adjusted model. A 31 cm 2 increase in VAT was significantly associated with a 1.8 mg/dL decrease in HDL in women (p=0.0007), but not in men (0.07 mg/dL increase, p=0.87). VAT change was not significantly associated with change in SBP in men or women. In this study of change in CT measured abdominal fat area in a large minority cohort, modest increases in VAT were significantly related to changes in HOMA and HDL, independent of changes in BMI. Further research is needed to determine whether preventing VAT accumulation may lead to improvements in glucose homeostasis and lipid profile.