tbuckley/cabot-search huggingface dataset:
Abstract 21574: Physical Performance of Outpatients Support by a Novel Lvad System
Authors: Martin Strueber
Journal: Circulation (2010)

LVAD support as destination therapy and prolonged bridge to transplant for patients with heart failure has become a clinical reality. We were analysing the outcome and physical performance of patients being implanted with the new HeartWare HVAD for chronic support. Methods: The HVAD left ventricular assist device was implanted into 60 consecutive patients with terminal heart failure at one institution. All patients were on catecholamine support prior to implant. In 12 patients venoarterial ECMO was already used for circulatory support prior to LVAD implantation. Survival, adverse events and physical performance were measured in these patients. Results: Hospital survival was 90% in this patient cohort. All surviving patients were discharged and followed up for survival and adverse events. One year survival was 83%. No removal of device occurred during the first year for recovery or heart transplantation. Main adverse events were multiorgan failure for the perioperative period (n=6). Causes of deaths were c...
Cabotegravir plus rilpivirine, once a day, after induction with cabotegravir plus nucleoside reverse transcriptase inhibitors in antiretroviral-naive adults with HIV-1 infection (LATTE): a randomised, phase 2b, dose-ranging trial
Authors: David A Margolis, Cynthia C Brinson, Graham H R Smith, Jerome de Vente, Debbie P Hagins, Joseph J Eron, Sandy K Griffith, Marty H St Clair, Marita C Stevens, Peter E Williams, Susan L Ford, Britt S Stancil, Melinda M Bomar, Krischan J Hudson, Kimberly Y Smith, William R Spreen
Journal: The Lancet Infectious Diseases (2015)
Abstract 4: What Is The Impact Of Prehospital Intubation On Survival In Patients With Moderate To Severe Traumatic Brain Injury?
Authors: Shawn Dowling, Erik P Hess, Christian Vaillancourt, George A Wells, Ian G Stiell
Journal: Circulation (2008)

Introduction: Prehospital intubation is the standard of care for patients with Glasgow Coma Score (GCS) < 9 but some have questioned its usefulness and safety. We compared in-hospital mortality for...
Cleaved high molecular weight kininogen binds directly to the integrin CD11b/CD18 (Mac-1) and blocks adhesion to fibrinogen and ICAM-1
Authors: Nijing Sheng, Michael B. Fairbanks, Robert L. Heinrikson, Gabriela Canziani, Irwin M. Chaiken, David M. Mosser, Hong Zhang, Robert W. Colman
Journal: Blood (2000)
Abstract 13513: Hydrogen Sulfide Preconditions the Diabetic Heart by Inactivating the Transcription Repressor Bach1 and Activating Nrf2 Signaling
Authors: Bridgette F Moody, Chad K Nicholson, Rebecca L Hood, John W Calvert
Journal: Circulation (2011)

Background: Hydrogen sulfide (H2S) is an endogenous signaling molecule with cardioprotective effects. Here we sought to examine if H2S preconditioning could provide cardioprotection in the setting ...
State-dependent alterations in the perception of life events in menstrual-related mood disorders
Authors: P J Schmidt, G N Grover, M C Hoban, D R Rubinow
Journal: American Journal of Psychiatry (1990)

The authors examined the reporting of daily life events by women with prospectively confirmed menstrual-related mood disorder (N = 40) and asymptomatic control subjects (N = 20). During the follicular and late luteal phases of the menstrual cycle, subjects completed a schedule of life events that monitors an individual's perception of 1) the frequency of occurrence of life events and 2) the degree of associated distress or pleasure. The patient group reported significantly more negative life events than the control group. Further, the patients with menstrual-related mood disorder showed significantly more distress associated with the same event when it occurred in the premenstrual phase than when it occurred in the post-menstrual phase.
Abstract 4305: Biodistribution and clearance of non-targeted DyLight dyes in tumor-free nude mice for <i>in vivo</i> imaging
Authors: Marie C. NLEND, Surbhi Desai, Suk J. Hong, Mary Beth Anderson, Georgyi V. Los, Greg T. Hermanson, Justin M. Diener, Warren M. Leevy, Peter A. Bell
Journal: Cancer Research (2014)

Abstract Far red to near infra red (NIR) fluorophores are commonly used in cell-based assays and for deep tissue in vivo imaging. The light emitting and physico-chemical characteristics of these fluorophores, e.g. excitation and emission spectra, relative hydrophilicity/hydrophobicity and molecule size, can significantly influence their performance in these applications. Currently there are no guidelines for selection of fluorophores optimal for targeted in vivo imaging. To address this issue we have designed a panel of DyLight dyes with maximum excitation wavelength in the range of 650 -785 nm, maximum emission wavelength in the range of 670 - 800 nm and different levels of sulfonation and/or PEGylation. We studied the kinetic of tissue distribution and clearance of these fluorophores as well as their effect on morphology of different tissues in mice after intravenous injection. Briefly, nude mice were anesthetized, injected with a dye (100 µL of dye at 0.5mg/ml in PBS) into retro-orbital plexus, and imaged using Carestream MSFX or Carestream XTREME Imager. Images were generated before dye injection, immediately after injection (0 hours) and 3, 6, 12 and 24 hours post injection. At the end of the experiment, animals were sacrificed; internal organs were collected and used for ex vivo analysis. The results of in vivo imaging experiments demonstrated that: hydrophobic fluorophores have a relatively slow kinetic of distribution and clearance, and often cleared via a hepatic pathway. Introduction of the negatively charged groups and or PEG chains increased dye solubility affected the kinetics of both fluorophore distribution and its clearance. In addition, negatively charged fluorophores had a tendency to be cleared predominantly via renal pathway. A histological analysis of the internal organs showed no detectable tissue damage. These results provide guidelines for the selection of optimal NIR dyes for in vivo imaging. Citation Format: Marie C. NLEND, Surbhi Desai, Suk J. Hong, Mary Beth Anderson, Georgyi V. Los, Greg T. Hermanson, Justin M. Diener, Warren M. Leevy, Peter A. Bell. Biodistribution and clearance of non-targeted DyLight dyes in tumor-free nude mice for in vivo imaging. [abstract]. In: Proceedings of the 105th Annual Meeting of the American Association for Cancer Research; 2014 Apr 5-9; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2014;74(19 Suppl):Abstract nr 4305. doi:10.1158/1538-7445.AM2014-4305
Relationship of A1C to Glucose Concentrations in Children With Type 1 Diabetes
Journal: Diabetes Care (2008)

Despite the standing of A1C as the most validated and widely used measure for average glycemic control over time, the relationship between A1C and glucose concentrations is not completely understood. The purpose of this Diabetes Research in Children Network (DirecNet) study was to use continuous glucose monitoring data to examine the relationship between A1C and glucose in type 1 diabetes.Forty-eight youth enrolled in studies of the Navigator continuous glucose monitor were encouraged to wear the Navigator sensor at home continuously. A1C was measured at baseline, at 3 months, and at 6 months. Sensor glucose data were directly transmitted via the Internet, assuring that essentially all glucose values were analyzed.Subjects had a median of 112 h/week of Navigator data in the first 3 months and 115 h/week in the second 3 months. The slope of mean glucose over the previous 3 months versus A1C was only 18 mg/dl per 1.0% A1C. Individually, there was substantial variation in the relationship between mean glucose and A1C. A1C was not associated with glucose lability after controlling for mean glucose. Measures of an individual's rate of glycation were moderately correlated at the 3- and 6-month visits.As the chemistry of glycation would predict, we found no evidence to contradict the simple hypothesis that A1C directly reflects mean glucose over time. There is, however, substantial variability in individual mean glucose concentrations for a given A1C. Transforming reliable A1C values into calculated mean glucose values would, when applied to an individual, introduce substantial error.
Abstract P272: Cumulative Risk for Hypercholesterolemia In Middle-Aged White and African American Men and Women
Authors: John Wilkins, Hongyan Ning, Sunny Intwala, Donald M Lloyd-Jones
Journal: Circulation (2014)

Introduction: The long-term risks for incident hypercholesterolemia (HC) have not been quantified by sex in AA men and women. Methods: We conducted an individual-level pooled analysis of participants from The Atherosclerosis Risk in Communities and The Framingham Offspring Studies with baseline prevalence and follow-up data on HC and lipid-lowering medications. Hypercholesterolemia was defined as a total cholesterol level &gt; 240mg/dL or the use of lipid-lowering medications on ≥2 consecutive examinations. We quantified the long-term risk for HC using competing risk models to assess incidence from age 55 years (y) though 70y to 85y, adjusted for baseline prevalence and competing risks of death. Analyses were stratified by race and sex. Results: There were 11,341 White and 2,828 AA participants (55% and 63% female, respectively) included in the analysis. At an index age of 55y the mean (SD) BMIs in White and AA (men/women) respectively were: 27.8(4.1)/26.9 (5.6) and 28.1(5)/31.3(6.7)Kg/m2. Baseline prevalence rates of HC were not substantially different across race and sex groups. White women had the highest risks for the development of HC, with long-term risks as high has 63% through age 80y. AA men had the lowest risks for hypercholesterolemia through at 70y. Conclusions: The burden of HC is substantial across all race groups, with the highest risks found in white women. Aggressive surveillance and early preventive efforts against HC are needed across all race and sex groups.
Role of c-MYC in normal intestinal development and tumorigenesis in the ApcMin/+ mouse
Authors: Natalia A. Ignatenko, Hana Holubec, David G. Besselsen, Karen A. Blohm-Mangone, Jose L. Padilla-Tores, Erika I. Dexter, Raymond B. Nagle, Eugene W. Gerner
Journal: Cancer Research (2005)

Proc Amer Assoc Cancer Res, Volume 46, 2005

1982 

The c-Myc oncogene plays an important role in tumorigenesis and is commonly activated in gastrointestinal cancers. In human colon tumor cells, c-Myc is regulated by the adenomatous polyposis coli (APC) tumor suppressor gene, which is mutated or deleted in humans with familial adenomatous polyposis (FAP). The ApcMin/+ (Min) mice are a model of FAP and are heterozygous for a truncating Apc mutation. We have developed a mouse model for studying the role of c-myc in the mutant APC-mediated colon tumorigenesis. Mice harboring a transgene containing the Cre recombinase under the control of transcriptional regulatory elements from a fatty acid-binding protein gene ( Fabp 4×at132) were crossed with mice homozygous for the c-mycflox allele. Progeny were then interbred to initiate the deletion of loxP flanked c-myc sequences in rapidly self-renewing mouse small intestinal and colonic epithelium. Cre expression and recombination in the transgenic c-myc null mouse ( Fabp  4×at 132  Cre transgenic mice x c-myc null) resulted in mosaic loss of the expression of the c-myc protein in ileum, cecum and colon tissues, in which the Fabp4×at 132 promoter is active. Conditional c-myc null mice exhibited underdeveloped intestinal crypts and villous atrophy. The results of recombination were evaluated microscopically using methylene-blue stained whole-mount preparations and were confirmed by morphology in H&E stained sections and by immunohistochemical analysis using c-MYC antibody. We crossed the Fabp4×at 132Cre c-myc null mouse to ApcMin/+ and then to their progeny - to create the ApcMin/+ mouse with intestinal specific knockout of the c-myc oncogene ( ApcMin/+ c-myc null). The compound ApcMin/+ c-myc null mouse was used to evaluate the effect of colon-specific c-myc knockout on the ApcMin/+ phenotype. We observed a relative reduction in the tumor number in the small intestine in ApcMin/+ c-myc conditional knockout mice compared to control ApcMin/+ mice. These data demonstrate that c-Myc is essential for normal development of intestinal epithelia and impacts either directly or indirectly Apc-dependent intestinal tumorigenesis in mice.
Cutting the Cost of Cold: Affordable Warmth for Healthier Homes
Authors: Jonathan M Samet
Journal: BMJ (2001)

Eds Fergus Nicol, Janet Rudge 

Spon Press, £35, pp 288 ISBN 0 419 25050 6

Rating: ![Graphic][1] ![Graphic][2] ![Graphic][3] 

Remarkably, even as we complete the sequencing of the human genome, we have only a limited understanding of how the quality of the home environment affects health. Cutting the Cost of Cold considers aspects of this environment, focusing on temperature, humidity, and biological agents, for which evidence about effects on health is remarkably deficient.

We cannot specify the optimum indoor temperature and humidity, particularly for infants, children, …

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Abstract 17102: Cognitive Function and Masked Hypertension in Older Hypertensive Patients
Authors: Manabu Hayakawa, Yuichiro Yano, Kazuyuki Shimada, Kazuomi Kario
Journal: Circulation (2014)

Background: Masked hypertension, defined as a normal blood pressure (BP) at the office/clinic but a higher BP outside, is associated with a high risk of cardiovascular events, but knowledge of the clinical characteristics is limited. In particular, whether the measurement of cognitive function is useful for identifying masked hypertension in older hypertensive patients remains uncertain. Methods: We enrolled 587 older hypertensive patients (mean age: 72 years; 52% were men; 79% had been treated with antihypertensive medications). All patients were ambulatory, lived independently, and were without clinically diagnosed dementia. Cognitive function was assessed by the mini-mental state examination (MMSE). The lowest quartile of the MMSE score distribution was defined as cognitive dysfunction (n=183:mean MMSE score: 24 points). Results: The proportion of well-controlled BP cases (office BP [OBP]  140/90 mmHg and 24-hour BP<130/80 mmHg), mas...
Seroprevalence of Coxiella burnetii antibodies in human immunodeficiency virus-positive patients in Jacarepaguá, Rio de Janeiro, Brazil
Authors: C.C. Lamas, T. Rozental, M.N. Bóia, A.R.M. Favacho, A.H. Kirsten, A.P.M. da Silva, E.R.S. de Lemos
Journal: Clinical Microbiology and Infection (2009)
Abstract 480: The Neurotrophin p75 Receptor Impairs Angiogenesis and Endothelial Progenitor Cell function.
Authors: Andrea Caporali, Elisabetta Pani, Atsuiko Oikawa, Graciela B Sala-Newby, Aurelie Leroyer, Chantal Boulanger, Brunella Cristofaro, Paolo Madeddu, Costanza Emanueli
Journal: Circulation (2007)

Neurotrophins (NTs), which are known to promote survival, differentiation, and regeneration of neural cells, were recently showed to exert cardiovascular actions. NTs act through two different classes of receptors, tropomyosin-related kinase receptors and a p75 receptor (NTR-p75), which belongs to the TNF receptor superfamily. We previously reported that NT-p75 expression by capillary ECs is insignificant under basal conditions, but it increases in the presence of diabetes and ischemia. Increased NTR-p75 expression by capillaries correlates with higher endothelial cell (EC) apoptosis and impaired angiogenesis. We hypothesized that NTR-p75 directly promotes apoptosis and depresses proliferation and migration of ECs and endothelial progenitor cells (EPCs). This would impair reparative neovascularization of ischemic muscles. To investigate our hypotheses, HUVECs and human blood-derived EPCs were infected with an adenovirus carrying  NTR-p75  ( Ad.NTR-p75 ) (100 to 500 moi) or with the control  Ad.Null . Apoptosis was evaluated by the Caspase-Glo ®  assay and by counting the number of apoptotic microparticles released by the cells in the culture medium. Cell cycle was evaluated by flow cytometer. Cell migratory capacity versus SDF-1 (100 ng/mL) was assessed in 24-well transmigration chamber (membrane pore size of 5μm). Moreover, unilateral limb ischemia was induced in CD1 mice and  Ad.NTR-p75  (10 9  pfu ) was immediately delivered into the ischemic adductor muscles to study the effect on capillary EC proliferation and apoptosis (by PCNA staining and TUNEL assay at 3d post-ischemia, respectively), muscular neovascularization (capillary density counting at 14d post-ischemia), and blood flow recovery (Lisca colour Doppler at 0, 3, 7, and 14d post-ischemia).  In vitro , NTR-p75 over-expression promoted apoptosis and the shedding of apoptotic microparticles, inhibited cell cycle progression, and impaired the migration versus SDF-1 of ECs and EPCs.  In vivo ,  Ad.NTR-p75  inhibited proliferation and induced apoptosis of muscular ECs, thus impairing post-ischemic neovascularization and blood flow recovery. Our results identify for the first time the anti-angiogenic function of NTR-p75 and the underpinned cellular mechanisms.
Letter by Hernández-Vaquero et al Regarding Article, “Saphenous Vein Graft Failure After Coronary Artery Bypass Surgery: Insights From PREVENT IV”
Authors: Daniel Hernández-Vaquero, Rocío Díaz, Jacobo Silva
Journal: Circulation (2015)

Hess and colleagues 1 are to be commended for their study of the predictors of saphenous vein graft failure (VGF) after coronary artery bypass grafting.To do this, they analyzed >30 variables in 1828 patients and created a rigorous logistic regression model using data from the Project of Ex Vivo Vein Graft Engineering via Transfection IV (PREVENT IV) trial. 2 The final result was that poor target artery quality, longer duration of surgery, use of endoscopic vein harvesting, use of clopidogrel or ticlopidine, and cerebrovascular disease were significantly associated with VGF.Discrimination is a measure of how well the model can separate those who will develop the event of interest (VGF) from those who will not.The area under the receiver-operating curve, or C statistic, indicates the probability that a randomly selected patient who will develop the event has a higher risk score than a randomly selected patient who will not develop it.Subsequently, a C statistic of 0.5 indicates no predictive ability, whereas a value of 1.0 represents perfect discrimination. 3ess and colleagues 1 say that their results may be used to identify patients at high risk for VGF who might be considered for coronary artery bypass grafting with non-vein graft conduits and who should be followed up closely for post-coronary artery bypass grafting VGF events.However, we were frankly surprised that the C statistic of their model was only 0.61.This, in the absence of other overall performance measures such as the R 2 coefficient, indicates that this model is barely able to predict whether a vein graft will fail. 3here are some reasons that could explain this circumstance.First, there may be a problem of collinearity resulting from the inclusion in the model of logically related variables such as endoscopic vein harvesting and surgical time.Second, there can be some unknown or nonstudied factors that influence VGF (eg, surgical skill).Finally, we cannot rule out that there is a large element of randomness in this outcome.These 3 elements could explain the great discrepancy between these results and others reported previously in the literature.
Task force 3: Disclosure of relationships with commercial interests: Policy for educational activities and publications
Authors: Alice K. Jacobs, Bruce D. Lindsay, Bruce J. Bellande, Gregg C. Fonarow, Rick A. Nishimura, Pravin M. Shah, Brian H. Annex, Valentin Fuster, Raymond J. Gibbons, Marcia J. Jackson, Shahbudin H. Rahimtoola
Journal: Journal of the American College of Cardiology (2004)
Abstract 18597: Systemic, Non-cerebral, Arterial Embolism in 21,105 Patients with Atrial Fibrillation Randomized to Edoxaban or Warfarin: Results from the ENGAGE AF-TIMI 48 Trial
Authors: Bram J Geller, Christian T Ruff, Robert P Giugliano, Sabina A Murphy, James J Hanyok, Jianqing Jin, Michele Mercuri, Elliott M Antman
Journal: Circulation (2014)

Background: Atrial fibrillation (AF) is widely recognized as a major risk factor for stroke and systemic embolism. Multiple trials comparing warfarin with factor specific oral anticoagulants have demonstrated that the newer agents are at least as effective as and generally safer than warfarin. However, none of these studies has provided a detailed analyses regarding systemic embolism, the less frequent component of the primary endpoint. Methods and Results: We did a prespecified analysis of data from the 21,105 patients with AF enrolled into ENGAGE AF-TIMI 48, a randomized trial comparing two once-daily regimens of edoxaban (high- and low-dose) with warfarin for the prevention of stroke and systemic embolism. Of the 1,016 patients who met the primary endpoint, 67 (6.6%) had a systemic embolic event (SEE) of which 13% were fatal. Risk factors for systemic embolism versus stroke include age (78 versus 74 years; P=0.005), permanent atrial fibrillation (72% versus 54%; P=0.009), and creatinine clearance ≤ 50 mL/min (42% versus 27%; P=0.01). Of the 73 total SEEs (includes multiple events), 62 involved the extremities (85%) and 30 required a surgical or percutaneous intervention (41%). In a meta-analysis of the four major trials comparing novel oral anticoagulants (NOACs) versus warfarin, the NOACs reduce the risk of SEE compared to warfarin (relative risk, 0.63; 95% confidence interval, 0.43 to 0.91; P=0.01), with less bleeding and a better safety profile. Conclusion: Although less frequent than stroke, systemic embolism results in significant morbidity and mortality in patients with AF. In a meta-analysis, NOACs reduce the risk of SEEs compared to warfarin.
Circulating type I collagen degradation products: a new serum marker for clinical severity in patients with scleroderma?
Authors: None Hunzelmann, None Risteli, None Risteli, None Sacher, None Vancheeswaran, None Black, None Krieg
Journal: British Journal of Dermatology (1998)

Systemic sclerosis (SSc; scleroderma) results in the excessive deposition of extracellular matrix components in affected organs. This is partly due to enhanced synthesis; however, the role of degradative processes in this disease is still poorly understood. Sera of 32 patients with SSc (22 with the diffuse, 10 with the limited form) and of six patients with morphoea were assessed using radioimmunoassays for the cross‐linked carboxy terminal telopeptide of type I collagen (ICTP) and for the amino terminal propeptide of type I procollagen (PINP) reflecting type I collagen degradation and synthesis, respectively. In 27 of the 32 patients with SSc, the concentration of ICTP was above the upper limit of the normal value (4.6 μg/L) and the mean level was clearly elevated at 7.92 μg/L. The ICTP concentration correlated with the skin score measuring the extent of the lesions, whereas no such correlation was found for PINP. The ICTP antigen in serum, studied by immunoblotting, had a molecular weight of about twice that of the trypsin‐generated fragment isolated from human bone collagen. The mean concentration of serum PINP was 43.9 μg/L and no patient exceeded the upper limit of the normal range (80 μg/L).We report here for the first time that the concentration of the type I collagen degradation product ICTP in serum shows a close correlation with the extent of skin fibrosis in patients with SSc. We conclude that the increased deposition of type I collagen in this disease is accompanied by an increased turnover of this molecule, indicating a more complex derangement of synthetic and degradative processes than previously acknowledged.
Targeting cancer-associated fibroblasts with a selective PDGF-R TK inhibitor as a therapeutic approach for solid tumors.
Authors: G. Gueguen, C. Volle-Challier, I. Blanc, C. Labouret, G. Morin, M-C. Laplace, M. Trombe, F. Dol and F. Bono
Journal: Journal of Clinical Oncology (2010)

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