tbuckley/cabot-search huggingface dataset:
Abstract 5638: New synthetic analogs of migrastatin as potent cell migration inhibitors to block overall metastasis in lung cancer and colorectal carcinoma
Authors: Nicolas Lecomte
Journal: Cancer Research (2012)

Abstract Tumour metastasis is the leading cause of death within cancer patients. Therefore the development of new small molecules targeting this process is crucial in the therapeutic arsenal. Migrastatin is a biologically active natural product isolated from Streptomyces that shows a high potency inhibition of tumor cell migration. Upon completing the first total synthesis of migrastatin, sets of structurally simplified synthetic analogs were developed. In the light of extensive in vitro screening leading to informative structureαactivity relationship, a new generation of analogs was launched which demonstrated higher levels of in vitro inhibitory activity, stability and synthetic accessibility. We investigated two promising ether-derivative analogs, the migrastatin core ether (ME) and the carboxymethyl-ME (CME). Both compounds exhibited high efficacy in blocking tumor cell migration in vitro with IC50 values in the micromolar range, more than two orders of magnitude less than the LD50 values. In the light of these results, in vivo efficacy of these compounds in inhibiting tumor metastasis was assessed in human tumor xenograft models established in NOD/SCID IL2R gamma null (NSG) mice. First in a human Small-Cell Lung Cancer (SCLC) primary xenograft model, developed by subcutaneous injection of tumor cells, ME and CME compounds were found to be highly potent in inhibiting overall metastasis even at the lowest dosage used (degree of inhibition: 96% and 99%, for ME and CME at 10mg/kg or 12mg/kg respectively). Next, in a human Colorectal Carcinoma (CRC) xenograft model, developed by intrasplenic injection of tumor cells, ME at the highest dosage (100mg/kg) was found to significantly reduce the metastatic spread to the liver, the lungs and the GI tract (degree of inhibition: 97%, 84% and 95% respectively). CME and ME selectively inhibited tumor cell migration in vitro and in vivo but neither compound inhibited tumor proliferation at the primary site of tumor injection or at the metastatic site if tumor metastases occurred prior inhibition by drug treatment. All together these very encouraging findings suggest that these analogs have promise as potent anti-metastatic agents in epithelial tumors. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 103rd Annual Meeting of the American Association for Cancer Research; 2012 Mar 31-Apr 4; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2012;72(8 Suppl):Abstract nr 5638. doi:1538-7445.AM2012-5638
"DRAINAGE OF APICAL ABSCESSES OF TEETH"
Authors: J. Howell Way
Journal: JAMA (1925)

To the Editor:  —I have read the answer on drainage of apical teeth abscesses, which interested me very much, believing, as I have for several years, that something should be done to curb the needless sacrifice of every tooth that an enthusiastic dentist thinks is infected, and should come out. I am consulted every week by some person who desires me to say what he or she should do relative to a dentist's advice to have certain teeth extracted. Recalling the writing of Dr. Benjamin Rush more than 100 years ago plus more than thirty-five years' practice of medicine, I am constrained at times to suggest going slower; but, as you know, it is a dangerous thing for a physician past 50 to make such suggestion. It makes him liable to be termed  man, but aleetlebehind the time. This I fear constrains some good doctors, with large
Standards of Normal in Gastric Secretion
Authors: WALTER C. ALVAREZ
Journal: Annals of Internal Medicine (1932)

Article1 September 1932Standards of Normal in Gastric SecretionWALTER C. ALVAREZ, M.D., F.A.C.P.WALTER C. ALVAREZ, M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-6-3-314 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptAfter approximately fifty years of stomach pumping and busy filling of archives with countless papers on gastric analysis, it would seem as if everything worth doing must have been done over and over again. Actually years of search through the enormous literature led me finally to the conclusion that most of the work on standards of normal which should have been done at the beginning has never been done, or at least, has never been done with enough material or with the technic that would satisfy a modern biometrician.The value of one gastric analysis. For instance: What is the...References1 OSTERBERGVANZANTALVAREZ AEFRWC: The determination of pepsin in the gastric content and its clinical significance in duodenal ulcer and pseudo-ulcer, Proc. Staff Meetings of Mayo Clinic, 1932, vii, 268-272. Google Scholar2 VANZANTALVAREZ FRWC: What is the value of one gastric analysis? A study of the daily variations in the gastric acidity of two normal persons, Proc. Staff Meetings of Mayo Clinic, 1931, vi, 419-422. Google Scholar3 VANZANTALVAREZEUSTERMANDUNNBERKSON FRWCGBHLJ: The normal range of gastric acidity from youth to old age: an analysis of 3,746 records. Arch. Int. Med., 1932, xlix, 345-359. CrossrefGoogle Scholar4 VANZANT FR: Personal communication to the author. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: WALTER C. ALVAREZ, M.D., F.A.C.P.Affiliations: Rochester, MinnesotaRead before the American College of Physicians, San Francisco, California, April 4, 1932. From the Division of Medicine, The Mayo Clinic, Rochester, Minnesota. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byThe Three Main Components of the Human Gastric Mucin: Dissolved Mucoproteose, Dissolved Mucoprotein, and Mucoid of the Gastric Visible MucusThe acidity of the “ulcer-bearing area” of the duodenum in normal personsThe effect of gastric hypersecretion on the reaction and neutralizing ability of the contents of the first part of the duodenum in normal dogsObservations on gastric acidity before and after development of carcinoma of the stomachThe relation in man between gastric acidity and height and weight 1 September 1932Volume 6, Issue 3Page: 314-318KeywordsArchivesStomach ePublished: 1 December 2008 Issue Published: 1 September 1932 PDF downloadLoading ...
The Office Practice of Internists
Authors: Hilda H. Kroeger
Journal: JAMA (1965)

This paper reports on some elements of a study which was developed in cooperation with the New York State Society of Internal Medicine. This organization was interested in the development of methodology for evaluating the quality of medical care being rendered by its members in their own offices. As a preliminary to the methodological study itself, information on the background and characteristics of the practice of the members of the society was obtained by means of a questionnaire mailed to each member. At the time of the study, the society had 960 members, of whom 505 returned a completed questionnaire to the study group. The nature of the society and the methodology of this study were outlined in the first paper of this series.<sup>1</sup>The other papers in the series covered patient load,<sup>2</sup>the characteristics of patients,<sup>3</sup>and the professional activities of internists other than the care
How should doctors decorate their consulting rooms?
Authors: M. Gaba
Journal: BMJ (2002)

How doctors decorate their consulting rooms can be a matter of style, personal preference, territorial imperatives, or culture. Some doctors believe that patients need to see certain images and motifs there. Take the average heterosexual middle aged clinician. He or she will have pictures of his or her family prominent on the desk, with kiddy drawings scattered around the walls. Doctors approaching retirement may have additional photos of grandchildren.

> Doctors should abstain from having family photos in their consulting rooms 

There is a widespread feeling in the medical profession that patients are reassured by seeing their doctor in a family role—one, it could be said, with which they can identify and which generates trust. Many doctors would recognise that having a family has immeasurably improved their consulting style; but is the consulting room truly the place to put the family on display? I really do not think so.

After reflecting on the vulnerability of my patients, I have removed my family photos from my consulting …
Patient-Physician Discussions About Physician-Assisted Suicide
Authors: Lauris C. Kaldjian
Journal: JAMA (2001)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Journals JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Oophorectomy Dramatically Reduces Risk of Cancer in<i>BRCA</i>Carriers
Authors: Anita Slomski
Journal: JAMA (2014)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Central venous catheter associated thrombosis of major veins: thrombolytic treatment with recombinant tissue plasminogen activator.
Authors: S Rodenhuis, L G van't Hek, L T Vlasveld, R Kroger, R Dubbelman, R G van Tol
Journal: Thorax (1993)

Major thromboses can occur in the venous system in association with central venous catheters. This usually necessitates removal of the catheter.The effectiveness of low dose recombinant tissue type plasminogen activator (rt-PA) in combination with heparin was assessed in patients with central venous catheter associated thrombosis.In five patients, all suffering from cancer, a 5-7 day continuous infusion resulted in complete lysis of the thrombus without complications in three. In the other two patients moderately severe haemorrhage was observed with only partial lysis, of the thrombus.The infusion of heparin and rt-PA is potentially effective in thrombosis related to use of central venous catheters, but the risk of haemorrhage is not inconsiderable.
Systemic autoimmunity and defective Fas ligand secretion in the absence of the Wiskott-Aldrich syndrome protein
Authors: Nikolay P. Nikolov, Masaki Shimizu, Sophia Cleland, Daniel Bailey, Joseph Aoki, Ted Strom, Pamela L. Schwartzberg, Fabio Candotti, Richard M. Siegel
Journal: Blood (2010)
Diagnosis and Treatment of <i>KIT</i>-Mutant Metastatic Melanoma
Authors: Megan Lyle, Georgina V. Long
Journal: Journal of Clinical Oncology (2013)

A 52-year-old man has unresectable locally recurrent melanoma of the left foot ( Fig 1 ) and pulmonary metastases. Nine months before this presentation, he underwent a wide local excision and sentinel node biopsy for an acral melanoma on his left heel. Pathology disclosed Breslow thickness of 4.8 mm, Clark level IV, and tumor ulceration with a mitotic rate of 37 mitoses/mm 2 . Both sentinel nodes in the left groin were positive for melanoma cells, which expressed S100, HMB45, and melan A. At subsequent left inguinal dissection, seven more nodes showed no additional nodal metastases. Within 3 months of his original surgery, the patient developed a local recurrence in the foot, and over the subsequent 6 months, he underwent serial local excisions and topical diphencyprone treatment. A recent staging scan showed at least 20 foci of in-transit disease in the left lower leg and foot, as well as a solitary lung metastasis (12 mm). His Eastern Cooperative Oncology Group performance status is 1, with no significant comorbidities. High-resolution melt followed by sequencing of an in-transit metastasis showed there is no BRAF exon 15 mutation. However, Sanger sequencing of KIT exons 9, 11, 13, and 17, performed as screening for a clinical trial enrolling patients with metastatic acral and mucosal melanomas, showed an exon 13 K642E mutation.
Pulmonary infiltrates and abdominal colic pain in a patient with a connective tissue disorder
Authors: G Herrero-Beaumont
Journal: Annals of the Rheumatic Diseases (2000)

Case reportA 32 year old white women was admitted to our hospital complaining of long term fever and fatigue.She reported recurrent episodes of fever lasting 7 to 10 days accompanied by joint pain and weakness during the past four months.Subsequently she developed a productive cough and pleuritic chest pain on the right side.She had not travelled recently or been exposed to contagious diseases.She had not noticed any skin lesions, but on specific questioning reported photosensitivity and Raynaud's phenomenon.She had a history of several lung infections and urolithiasis.She had had two normal deliveries and no miscarriages.There was a family history of interstitial lung disease.On admission she was febrile (37.8°C).Physical examination revealed a conjunctival injection and bilateral submandibular lymph nodes.Wheezes were audible in the right lung base.Cardiac auscultation and abdominal palpation were unremarkable.Joint examination showed tenderness of proximal interphalangeal joints.Laboratory data included the following: erythrocytes 4.75 × 10 12 /l, haemoglobin 128 g/l, platelets 200 × 19 9 /l, leucocytes 6.8 x 10 9 /l and erythrocyte sedimentation rate (ESR) 70 mm 1st h.Serum biochemistry: creatinine 110 µmol/l (normal range 60-110), calcium 2.42 mmol/l (2.1-2.5) and phosphorous 0.69 mmol/ l.(0.97-1.45).Urine density was 1010, pH 7 and there were 12-20 erythrocytes/high magnification field and amorphous carbonates in the sediment.Immunoglobulins: IgG 22 g/l (8-16), IgA 2.23 g/l (1-3), IgM 1.24 g/l (0.8-2.5).Results were negative for HIV, Epstein-Barr serology, tuberculin test and direct examination of acid-alcohol resistant mycobacteria in sputum.A chest radiograph showed bilateral interstitial infiltrates at the lung bases (fig 1) and thoracic computed tomography confirmed the lesions (fig 2).Bronchial lavage cultures demonstrated a growth of an ampicillin resistant Haemophilus influenzae.She was given cefotaxime, 2 g three times daily.During admission she developed an acute episode of abdominal pain accompanied by hypotension and vomitting.Plain radiographs (fig 3) showed multiple calcifications in both renal silhouettes.Urograms revealed a func-
The importance of injecting vaccines into muscle
Authors: J. N Zuckerman
Journal: BMJ (2000)

Most vaccines should be given via the intramuscular route into the deltoid or the anterolateral aspect of the thigh. This optimises the immunogenicity of the vaccine and minimises adverse reactions at the injection site. Recent studies have highlighted the importance of administering vaccines correctly.1–3 Clinical practice needs to reflect considerations about the right length and gauge of needles used to ensure that those vaccinated get the immunological benefit of the vaccines without local side effects.

Injecting a vaccine into the layer of subcutaneous fat, where poor vascularity may result in slow mobilisation and processing of antigen, is a cause of vaccine failure1—for example in hepatitis B,2 rabies, and influenza vaccines.3 Compared with intramuscular administration, subcutaneous injection of hepatitis B vaccine leads to significantly lower seroconversion rates and more rapid decay of antibody response.1

Traditionally the buttocks were thought to be an appropriate site for vaccination, but …
BCL6 modulates tonic BCR signaling in diffuse large B-cell lymphomas by repressing the SYK phosphatase, PTPROt
Authors: Przemyslaw Juszczynski, Linfeng Chen, Evan O'Donnell, Jose M. Polo, Stella M. Ranuncolo, Riccardo Dalla-Favera, Ari Melnick, Margaret A. Shipp
Journal: Blood (2009)
Clinical effects of anticoagulant therapy in suspected acute myocardial infarction: systematic overview of randomised trials
Authors: R. Collins, S. MacMahon, M. Flather, C. Baigent, L. Remvig, S. Mortensen, P. Appleby, J. Godwin, S. Yusuf, R. Peto
Journal: BMJ (1996)

Most randomised trials of anticoagulant therapy for suspected acute myocardial infarction have been small and, in some, aspirin and fibrinolytic therapy were not used routinely. A systematic overview (meta-analysis) of their results is needed, in particular to assess the clinical effects of adding heparin to aspirin.Computer aided searches, scrutiny of reference lists, and inquiry of investigators and companies were used to identify potentially eligible studies. On central review, 26 studies were found to involve unconfounded randomised comparisons of anticoagulant therapy versus control in suspected acute myocardial infarction. Additional information on study design and outcome was sought by correspondence with study investigators.Patients with suspected acute myocardial infarction.No routine aspirin was used among about 5000 patients in 21 trials (including half of one small trial) that assessed heparin alone or heparin plus oral anticoagulants, and aspirin was used routinely among 68,000 patients in six trials (including the other half of one small trial) that assessed the addition of intravenous or high dose subcutaneous heparin.Death, reinfarction, stroke, pulmonary embolism, and major bleeds (average follow up of about 10 days).In the absence of aspirin, anticoagulant therapy reduced mortality by 25% (SD 8%; 95% confidence interval 10% to 38%; 2P = 0.002), representing 35 (11) fewer deaths per 1000. There were also 10 (4) fewer strokes per 1000 (2P = 0.01), 19 (5) fewer pulmonary emboli per 1000 (2P < 0.001), and non-significantly fewer reinfarctions, with about 13 (5) extra major bleeds per 1000 (2P = 0.01). Similar sized effects were seen with the different anticoagulant regimens studied. In the presence of aspirin, however, heparin reduced mortality by only 6% (SD 3%; 0% to 10%; 2P = 0.03), representing just 5 (2) fewer deaths per 1000. There were 3 (1.3) fewer reinfarctions per 1000 (2P = 0.04) and 1 (0.5) fewer pulmonary emboli per 1000 (2P = 0.01), but there was a small non-significant excess of stroke and a definite excess of 3 (1) major bleeds per 1000 (2P < 0.0001).The clinical evidence from randomised trials dose not justify the routine addition of either intravenous or subcutaneous heparin to aspirin in the treatment of acute myocardial infarction (irrespective of whether any type of fibrinolytic therapy is used).
Detection of Cardiac Myxoma by F-18 FDG PET
Authors: DENIS AGOSTINI, GÉRARD BABATASI, FRANĈOISE GALATEAU, GILLES GROLLIER, JEAN CLAUDE POTIER, GÉRARD BOUVARD
Journal: Clinical Nuclear Medicine (1999)

Intracardiac tumors occur infrequently and are difficult to diagnose with CT and MRI. The authors describe the successful imaging of a right atrial myxoma with F-18 FDG PET.
Underfeeding of Babies
Authors: D. Morris
Journal: BMJ (1957)

Lateral lumbar interbody fusion (LLIF) is a powerful tool in minimally invasive spine surgery with high rates of fusion, excellent indirect decompression, and deformity correction. LLIF offers advantages compared with anterior lumbar interbody fusion including a more favorable complication profile. Traditionally, the interbody fusion is performed in the lateral position and fluoroscopy-assisted pedicle screw fixation performed with the patient repositioned prone. The evolution of both pedicle screw technology and intraoperative navigation has enhanced the feasibility of single (lateral)-position surgery. Early reports using fluoroscopy-assisted pedicle screws and computer or robotic navigation suggest this technique can be performed safely and accurately. The purpose of this brief report is to provide the technical steps, workflow, as well as pearls and pitfalls for single-position LLIF with true intraoperative computed tomography navigation-guided percutaneous pedicle screw fixation. A case example is included for illustration.