OCHRONOSIS: REPORT OF A CASE
Authors: A M MINNO, J A ROGERS
Journal: Annals of Internal Medicine (1957)

Case Reports1 January 1957OCHRONOSIS: REPORT OF A CASEALEXANDER M. MINNO, M.D., JAMES A. ROGERS, M.D.ALEXANDER M. MINNO, M.D.Search for more papers by this author, JAMES A. ROGERS, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-46-1-179 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptOchronosis is an extremely rare disorder but, when present, is quite disabling. We have recently had an opportunity to observe a patient with alkaptonuria and secondary ochronosis. It has been noted that alkaptonuria may be present for many years before the signs and symptoms of ochronosis become pronounced. If alkaptonuria is detected early, the onset of the so-called alkaptonuric or ochronotic osteoarthritis may perhaps be delayed.In 1866 Virchow recorded the first case of ochronosis, describing the pigmentation of cartilage and other tissues. More than 200 cases of alkaptonuria and 100 cases of ochronosis have since been reported. Several groups...Bibliography1. Black RL: Use of cortisone in alkaptonuria, J. A. M. A. 155: 968-970 (July 10) 1954. CrossrefMedlineGoogle Scholar2. CoodleyGreco ELAJ: Clinical aspects of ochronosis, with report of a case, Am. J. Med. 8: 816-822 (June) 1950. CrossrefGoogle Scholar3. GaldstonSteeleDobriner MJMK: Alcaptonuria and ochronosis with a report of 3 patients and metabolic studies in 2, Am. J. Med. 13: 432-452 (Oct.) 1952. CrossrefMedlineGoogle Scholar4. HenchBauerGrahamBolandHolbrookCrainLockieFreybergMcEwenStecherRosenberg PSWWEWWPDCLMRCRMEF: Rheumatism and arthritis: review of American and English literature of recent years (Ninth Rheumatism Review), Part II, Ann. Int. Med. 28: 309-451 (Feb.) 1948. LinkGoogle Scholar5. MartinUnderdahlMathieson WJLODR: Alkaptonuria: report of 3 cases, Proc. Staff Meet., Mayo Clin. 27: 193-200 (May 7) 1952. MedlineGoogle Scholar6. TaggartBonnerGaldstonMasonPinesHeath JVDMMHHKLFK: Inborn errors of metabolism, Am. J. Med. 8: 90-105 (Jan.) 1950. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Boston, Massachusetts*Received for publication September 16, 1955.From the Department of Internal Medicine, The Lahey Clinic, Boston, Massachusetts.Requests for reprints should be addressed to Alexander M. Minno, M.D., Lahey Clinic, 605 Commonwealth Avenue, Boston 15, Massachusetts. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byDisorders of phenylalanine and tyrosine metabolismTotal Knee and Hip Reconstruction in Male Patient with Alkaptonuria with 3 Years of follow up: Case Report and Review of the LiteratureA case report of Alcaptonuria.Alkaptonuria: A Case ReportAlkaptonuria: Case Report and Review of the LiteratureAlkaptonuriaThe skin in genetically-controlled metabolic disorders.Biochemical, pathologic and clinical aspects of alcaptonuria, ochronosis and ochronotic arthropathyRHEUMATISM AND ARTHRITIS: REVIEW OF AMERICAN AND ENGLISH LITERATURE OF RECENT YEARS (THIRTEENTH RHEUMATISM REVIEW)*CHARLEY J. SMYTH, M.D., F.A.C.P., ROGER L. BLACK, M.D., FELIX E. DEMARTINI, M.D., IVAN F. DUFF, M.D., F.A.C.P., EPHRAIM P. ENGLEMAN, M.D., F.A.C.P., DONALD C. GRAHAM, M.D., F.R.C.P.(C), MAX M. MONTGOMERY, M.D., F.A.C.P., HOWARD F. POLLEY, M.D., F.A.C.P., EDWARD F. ROSENBERG, M.D., F.A.C.P., CARLOS F. SACASA, M.D., F.A.C.P., OTTO STEINBROCKER, M.D., HANS WAINE, M.D., GEORGE M. WILSON JR., M.D. 1 January 1957Volume 46, Issue 1Page: 179-183KeywordsCartilageOsteoarthritisProteinsSigns and symptoms ePublished: 1 December 2008 Issue Published: 1 January 1957 PDF downloadLoading ...