Neonatal Thrombocytopenia Complicating Autoimmune Thrombocytopenia in Pregnancy
Authors: L.M. KERNOFF
Journal: Annals of Internal Medicine (1979)

Brief Reports1 January 1979Neonatal Thrombocytopenia Complicating Autoimmune Thrombocytopenia in PregnancyEvidence for Transplacental Passage of Antiplatelet AntibodyL.M. KERNOFF, Ph.D, E. MALAN, K. GUNSTONL.M. KERNOFF, Ph.DSearch for more papers by this author, E. MALANSearch for more papers by this author, K. GUNSTONSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-90-1-55 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTransient thrombocytopenia may occur in infants born to mothers suffering from autoimmune thrombocytopenic purpura (1) and is believed to result from transplacental passage of maternal immunoglobulin (Ig) G antiplatelet antibody (2). Although this humoral mechanism generally has been accepted (3), it has remained unproven, because the antibody has not been shown in either the serum or attached to the platelets of the affected child. A sensitive antiglobulin consumption assay that is capable of measuring nanogram amounts of platelet-bound IgG (platelet antibody) has recently been reported (4). This assay has enabled us to show that the thrombocytopenia occurring in a child...References1. TERRITOFINKELSTEINOHHOBELKATTLOVE MJWCH: Management of autoimmune thrombocytopenia in pregnancy and in the neonate. Obstet Gynecol 41:579-584, 1973 MedlineGoogle Scholar2. SHULMANMARDERWEINRACH NVR: Similarities between known antiplatelet antibodies and the factor responsible for thrombocytopenia in idiopathic purpura: physiologic, serologic and isotopic studies. Ann NY Acad Sci 124:499-542, 1965 CrossrefMedlineGoogle Scholar3. KARPATKINGARGSISKIND SSG: Autoimmune thrombocytopenic purpura and the compensated thrombocytolytic state. Am J Med 51:1-4, 1971 CrossrefMedlineGoogle Scholar4. DIXONROSSEEBBERT RWL: Quantitative determination of antibody in idiopathic thrombocytopenic purpura: correlation of serum and platelet-bound antibody with clinical response. N Engl J Med 292:230-236, 1975 CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: The Groote Schuur Hospital, Observatory Cape Town South Africa PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByHas Percutaneous Umbilical Blood Sampling Improved the Outcome of High-Risk Pregnancies?Low fetal risks in pregnancies associated with idiopathic thrombocytopenic purpuraImmune thrombocytopenia in pregnancyMolecular and genetic characteristics of pathogenic autoantibodiesDoes maternal platelet-associated or platelet-bindable IgG correlate with levels in umbilical cord blood or colostrum during normal pregnancy?High-dose intravenous gammaglobulin therapy for neonatal autoimmune thrombocytopeniaCase Report: Immune Thrombocytopenia: Effects of Maternal Gamma Globulin Infusion on Maternal and Fetal Serum, Platelet, and Monocyte IgGThrombocytopeniaAutoimmune thrombocytopenic purpura: Current concepts and recommended practicesStörungen der HämostaseChronic autoimmune thrombocytopenic purpuraImmune Thrombocytopenic Purpura and PregnancyTreatment of Idiopathic Thrombocytopenic PurpuraAutoimmune Thrombocytopenia in Dogs and CatsPlatelet Disorders in PregnancyNeonatal alloimmune thrombocytopenia complicated by maternal autoimmune thrombocytopenia.Idiopathic Thrombocytopenic Purpura: Mother and NeonateMICHAEL KORNSTEIN, J. ROBERT SMITH, M.D., JAMES A. STOCKMAN III, M.D. 1 January 1979Volume 90, Issue 1Page: 55-56KeywordsAntibodiesAntiplatelet antibodiesIdiopathic thrombocytopenic purpuraInfantsPlateletsPregnancy Issue Published: 1 January 1979 PDF DownloadLoading ...