THE RECOVERY OF STREPTOMYCIN-SENSITIVE TUBERCLE BACILLI FROM A PATIENT WITH PULMONARY TUBERCULOSIS WHO HAD PREVIOUSLY YIELDED HIGHLY RESISTANT BACILLI
Authors: R S MITCHELL, E WOLINSKY, W STEENKEN
Journal: Annals of Internal Medicine (1952)

Case Reports1 May 1952THE RECOVERY OF STREPTOMYCIN-SENSITIVE TUBERCLE BACILLI FROM A PATIENT WITH PULMONARY TUBERCULOSIS WHO HAD PREVIOUSLY YIELDED HIGHLY RESISTANT BACILLIROGER S. MITCHELL, M.D., EMANUEL WOLINSKY, M.D., WILLIAM STEENKEN JR.ROGER S. MITCHELL, M.D.Search for more papers by this author, EMANUEL WOLINSKY, M.D.Search for more papers by this author, WILLIAM STEENKEN JR.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-36-5-1309 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe appearance of streptomycin-resistant tubercle bacilli in the sputum of streptomycin-treated patients with pulmonary tuberculosis has been repeatedly found to coincide with a loss of clinical effectiveness of the drug. Tubercle bacilli exhibiting streptomycin sensitivity, as well as others with different degrees of streptomycin resistance, have occasionally been recovered from one or more lesions in the same patient, both at post mortem,1-6and from surgically resected lung tissue.1, 7There is no published evidence to date that highly streptomycin-resistant tubercle bacilli may become streptomycin-sensitive after repeated in vitro passage in culture media both with and without streptomycin. Serial animal passage...Bibliography1. Steenken W: Unpublished data. Google Scholar2. MedlarBernsteinReeves EMSFC: The demonstration of streptomycin-resistant tubercle bacilli in necropsy specimens, Am. Rev. Tuberc. 63: 449, 1951. MedlineGoogle Scholar3. ArmstrongWalker ARAM: Distribution of streptomycin-sensitive tubercle bacilli in lungs of a "resistant" patient, Canad. M. A. J. 60: 383, 1949. MedlineGoogle Scholar4. LucchesiMastantuono MC: Local variations in the resistance to streptomycin of tubercle bacilli in tuberculosis treated with streptomycin, Rass. Tisiol. Med. 3: 189, 1950. Google Scholar5. CanettiSaenz GA: La streptomycino-résistance de souches de bacilles de Koch provenant de lésions pulmonaires différentes d'un même malade, Ann. Inst. Pasteur 80: 238, 1951. MedlineGoogle Scholar6. SaenzCanetti AG: La streptomycino-résistance du bacille de Koch en fonction de la dose de streptomycine administrée (étude de 153 souches isolées chez des tuberculeux pulmonaires), Rev. de la tuberc. 13: 746, 1949. Google Scholar7. D'EsopoMedlar NDEM: Unpublished data. Google Scholar8. Steenken W: Streptomycin and the tubercle bacillus, Section III in Streptomycin and Dihydrostreptomycin in Tuberculosis, Edited by H. McLeod Riggins and H. Corwin Hinshaw, 1949, National Tuberculosis Association. Google Scholar9. Fisher MW: Fitzsimons Army Hospital's report on development of resistance, Minutes of the Fifth Streptomycin Conference, Veterans Administration, p. 74, April, 1948. Google Scholar10. FerebeeAppel SHFW: Resistance to streptomycin of tubercle bacilli isolated from patients treated with streptomycin, Pub. Health Rep. 66: 277, 1951. CrossrefMedlineGoogle Scholar11. KarlsonCarrHofmannPfeutze AGDTGNKH: The frequency of drug-resistant tubercle bacilli following administration of dihydrostreptomycin and para-aminosalicylic acid three days per week, Proc. Staff Meet., Mayo Clin. 26: 437, 1951. MedlineGoogle Scholar12. SteenkenWolinsky WE: Resistance of tubercle bacilli to streptomycin, Chapter II in Streptomycin, Edited by Selman A. Waksman, 1949, Williams and Wilkins, Baltimore. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: ROGER S. MITCHELL, M.D.; EMANUEL WOLINSKY, M.D.; WILLIAM STEENKENJR.Affiliations: Trudeau, N. Y.*Received for publication January 9, 1952.From Trudeau Sanatorium, and The Trudeau Laboratory of The Trudeau Foundation for the Clinical and Experimental Study of Pulmonary Disease, Trudeau, New York. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byReversion to drug sensitivity in tubercle bacilliEmergence of Antibiotic-Resistant Bacteria 1 May 1952Volume 36, Issue 5 Page: 1309-1317 Keywords Drugs Lesions Lungs Pulmonary diseases Research laboratories Sputum Streptomycin ePublished: 1 December 2008 Issue Published: 1 May 1952 PDF downloadLoading ...