tbuckley/cabot-search huggingface dataset:
Polymerized type I collagen reverts airway hyperresponsiveness development in a guinea pig asthma model
Authors: Blanca Bazan-Perkins, Maria G. Campos, Fernando Gutierrez-Aguilar, Patricia Ramos-Ramirez, Paola Moreno-Άlvarez, Edgar Sanchez-Guerrero
Journal: European Respiratory Journal (2011)

Recently, polymerized type I collagen (PolC) has been shown to display anti-inflammatory and anti-fibrotic properties in an asthma model. The effect of PolC in the pathophysiology of asthma is unknown. Our aim was to study the effects of PolC in airway obstruction and responsiveness in a guinea pig model of allergic asthma with remodelled airways. After an initial sensitization protocol, guinea pigs were intermittently exposed to allergen (ovalbumin, OA) applied every 10 days for up to 125 days (asthma model group), receiving a total of 12 OA challenges. The control group received saline solution instead of OA. Some animals from both asthma model and control groups were treated with 0.66 mg/ml PolC aerosols administered every 5 days from day 65 to 120. Airway responsiveness to histamine was evaluated before the first OA challenge and at the sixth and twelfth OA challenges. From the first challenge on, OA induced a transient airway obstruction and a progressive rise in baseline Penh (a broncho-obstruction index), measured by barometric plethysmography, which was not modified by PolC treatments. At the sixth challenge, OA-induced hyperresponsiveness was abolished at twelfth OA challenge by PolC treatment. In a separate guinea pig group euthanized at the sixth OA challenge, airway subepithelial fibrosis (determined by morphometry) and granulocyte infiltration were observed. PolC treatment reduced both, granulocyte and fibrosis observed at the twelfth challenge. Our data suggest that the rise of Penh baseline is not induced by airway fibrosis, and that PolC is a biodrug which might become a pharmacological tool to reduce fibrosis, inflammation and hyperresponsiveness in asthma.
Abstract 17200: Altered Nuclear and Cytoskeletal Mechanics and Defective Cell Adhesion in Cardiac Myocytes Carrying the Cardiomyopathy LMNA D192G Mutation
Authors: Orfeo Sbaizero, Thomas Lanzicher, Valentina Martinelli, Carlin Long, Dobrmir Slavov, Giorgia Del Favero, Matthew Taylor, Luisa Mestroni
Journal: Circulation (2014)

Introduction:  Previous investigations suggested that lamin A/C gene (LMNA) mutations, which cause a variety of human diseases including muscular dystrophies and dilated cardiomyopathy, alter the nuclear mechanical properties.   Hypothesis:  We hypothesized that not only the nucleus, but also the whole-cell biomechanical behavior may be altered in cardiomyocytes with the dilated cardiomyopathy LMNA D192G mutation.   Methods:  We combined atomic force microscopy (AFM), molecular and cellular biology methodologies to study the biomechanics of the nucleus and whole-cell. Neonatal rat ventricular myocytes (NRVMs) were infected with adenoviral vectors containing either wild type or LMNA D192G. LMNA protein expression was confirmed up to day 6. Nuclear and whole-cell biomechanics were investigated in LMNA D192G, wild type and control NRVMs, .   Results:  Live-cell AFM force-deformation curves from days 1 through 6 showed that LMNA D192G nuclei displayed higher stiffness and fragility compared to controls with a peak at 72h (P   Conclusions:  Our study suggests that the cardiomyopathy LMNA D192G mutation has a profound effect on the whole-cell biomechanics in cardiomyocytes, extending beyond the increased nuclear stiffness and fragility, and involving cytoskeletal structural modifications and reduced cell membrane adhesion, changes that can be rescued by wild-type LMNA.
Difference in Budd‐Chiari syndrome between the west and china
Authors: Xingshun Qi, Xiaozhong Guo, Daiming Fan
Journal: Hepatology (2014)

Potential conflict of interest: Nothing to report. Author names in bold designate shared co‐first authorship. To the Editor: We read with great interest the review by Wang and colleagues1 that comprehensively analyzed the similarity and discrepancy in the epidemiology and characteristics of liver diseases between China and Western countries. Several common liver diseases were discussed, such as viral hepatitis, alcoholic liver disease, nonalcoholic fatty liver diseases, liver cirrhosis, and hepatocellular carcinoma. Herein, we express additional concern about Budd‐Chiari syndrome (BCS) which is a vascular liver disease resulting in life‐threatening liver failure and portal hypertension–related complications.2 The sites of occlusion, clinical presentations, etiological distributions, and preferred treatment modalities of BCS may be different between Western and Chinese populations. First, the occlusion is often located at the hepatic veins in the West. By comparison, a combined occlusion of hepatic vein and inferior vena cava is the most frequent type of BCS in China. Second, most Western patients have a rapid disease course with progressive hepatic function impairment due to acute thrombosis within the hepatic veins. However, a majority of Chinese patients have a relatively long history of abdominal wall varices and lower limb edema due to chronic occlusion of the inferior vena cava.3 Third, approximately 80% of Western patients have at least one thrombotic risk factor,4 such as myeloproliferative neoplasms with or without JAK2 V617F mutation, factor V Leiden mutation, prothrombin G20210A mutation, and paroxysmal nocturnal hemoglobinuria. In contrast, these are less frequently observed in Chinese patients.5 Fourth, anticoagulation and transjugular intrahepatic portosystemic shunt are the mainstay treatment options for Western patients. On the contrary, our recent survey of 23,352 Chinese BCS patients suggests that percutaneous recanalization is the most common treatment modality.7 This is because percutaneous recanalization alone can achieve an excellent long‐term patency and survival in most Chinese BCS patients. Collectively, the difference in the characteristics of BCS between the West and China should be clearly recognized by Chinese hepatologists.
Abstract 16320: Role of High Mobility Group Box 1 Protein Expression in the Development of Experimental Abdominal Aortic Aneurysm
Authors: Takashi Kohno, Toshihisa Anzai, Hidehiro Kaneko, Hideyuki Shimizu, Masayuki Shimoda, Taku Miyasho, Minoru Okamoto, Hiroshi Yokota, Shingo Yamada, Tsutomu Yoshikawa, Yasunori Okada, Ryohei Yozu, Keiichi Fukuda
Journal: Circulation (2010)
Subclinical Thyroid Disease and Cardiovascular Disease
Authors: Nadia Caraccio, Angela Dardano, Fabio Monzani
Journal: JAMA (2005)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Surgery in the Alleviation of Dyspareunia
Authors: A. M. Agnew
Journal: BMJ (1959)

BDICALJOURNALtesticular swelling probably suggests a certain amount of damage to the testicular structure though not sufficient to cause complete atrophy.Summary Histological proof is given that division of the spermatic cord can be done safely in repair of inguinal hernia.This procedure may be suitable in the indirect inguinal hernias of adults, and especially after the age of 35-40 years during the primary repair, as well as in recurrent hernias.With the present use of antibiotics the incidence of atrophy could be minimized and gangrene be prevented.
THE ACTIVITIES OF THE AMERICAN COLLEGE OF PHYSICIANS IN GRADUATE MEDICAL EDUCATION
Authors: Hugh J. Morgan
Journal: Annals of Internal Medicine (1940)

Article1 August 1940THE ACTIVITIES OF THE AMERICAN COLLEGE OF PHYSICIANS IN GRADUATE MEDICAL EDUCATIONHUGH J. MORGAN, M.D., F.A.C.P.HUGH J. MORGAN, M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-14-2-308 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptDuring recent years interest in graduate medical education has increased steadily. Practitioners in the clinical branches recognize the fact that medical knowledge changes and that methods of practice should change also and with as little lag in application as possible. Thus the demand from practitioners for opportunity and guidance, in what Bruce has aptly called continuation study. Moreover, current graduates in Medicine no longer consider their education completed when the medical degree is conferred. Medical education and training for medical practice, whether the latter be general or confined to a special field, are recognized as continuing processes. Reflections of this... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Nashville, Tennessee*Read at the Cleveland meeting of the American College of Physicians April 1, 1940. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 August 1940Volume 14, Issue 2Page: 308-313KeywordsContinuing medical educationGraduate medical educationMedical education Issue Published: 1 August 1940 PDF DownloadLoading ...
THE MANAGEMENT OF INFECTIONS OF THE URINARY TRACT
Authors: E N COOK
Journal: Annals of Internal Medicine (1955)

Article1 August 1955THE MANAGEMENT OF INFECTIONS OF THE URINARY TRACTEDWARD N. COOK, M.D.EDWARD N. COOK, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-43-2-316 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThere is no other urologic complaint which receives a lesser degree of competent management than do infections of the urinary tract. This sad state prevails in spite of the fact that our means of diagnosis in such conditions are equal or superior to those applying to almost any other disease to which the human being falls heir. Moreover, we do have means of managing most of these situations if we will but use the simplest of diagnostic methods, supplemented at times by more detailed technical procedures.THE EXERCISE OF COMMON SENSEPerhaps my approach to this discussion appears to be... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Rochester, Minnesota*From the Symposium on Infection, presented at the Thirty-sixth Annual Session of the American College of Physicians, Philadelphia, Pennsylvania, April 29, 1955.From the Section of Urology, Mayo Clinic and Mayo Foundation, Rochester, Minnesota. The Mayo Foundation, Rochester, Minnesota, is a part of the Graduate School of the University of Minnesota. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byPyrexia Following CystoscopyThe SulfonamidesSULFADIMETHOXINE IN URINARY TRACT INFECTIONS*The Medical Management of Urinary Tract InfectionsManagement of Pyelonephritis 1 August 1955Volume 43, Issue 2Page: 316-322KeywordsGraduate medical educationLesionsProstatitisProteinsPseudomonasPseudomonas infectionsStreptococcal infectionsUrinary tract infectionsUrologic infectionsUrology ePublished: 1 December 2008 Issue Published: 1 August 1955 PDF downloadLoading ...
Interns soon lose enthusiasm
Authors: J. Hopkins
Journal: BMJ (2002)

Interns' moods turn sour only months into their first postgraduate year, an US study suggests ( JAMA 2002;287:3143-6).

The moods of 61 internal medicine interns at the Hospital of the University of Pennsylvania in Philadelphia were measured at the beginning of training in June then in November, February, and at the end of the first year in June. The internship year is typical of those in the United States. It consists of two months in the intensive care unit with every third night on call, seven months in inpatient care with every fourth night on call, two months …
CHLOROMA; REPORT OF A CASE
Authors: Harold R. Roehm, Aaron Riker, Richard E. Olsen
Journal: Annals of Internal Medicine (1937)

Case Reports1 January 1937CHLOROMA; REPORT OF A CASEHAROLD R. ROEHM, M.D., F.A.C.P., AARON RIKER, A.B., M.D., RICHARD E. OLSEN, Sc.D., M.D.HAROLD R. ROEHM, M.D., F.A.C.P.Search for more papers by this author, AARON RIKER, A.B., M.D.Search for more papers by this author, RICHARD E. OLSEN, Sc.D., M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-10-7-1054 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptChloroma is not a common form of malignant tumor. Washburn1 in a review of the literature through June 1929 found 162 cases. Since that time 32 more have been reported, bringing the total to 194.Dock and Warthin2 in 1904 published an exhaustive study of the clinical and histological features of the disease. Their conclusion was that, "chloroma is a tumor-like hyperplasia of the parent cells of the leukocytes, primarily in red marrow, the periosteum being secondarily involved."In the past, opinions have been divided concerning the lymphatic or myelogenous origin of the neoplasm, but the general opinion at present...Bibliography1. WASHBURN AH: Chloroma, Am. Jr. Dis. Child., 1930, xxxix, 330-348. CrossrefGoogle Scholar2. DOCKWARTHIN GAS: A new case of chloroma with leukemia, with a study of cases reported since 1893, Med. News, 1904, lxxxv, 971, 1025, 1078, 1118. Google Scholar3. LECÈNE MP: Un cas de "chlorome" de l'extremité supérieure de l'humérus traité par la reséction étendue, Bull. et mém. Soc. nat. de chir., 1927, liii, 1328-1331. Google Scholar4. SWANSON LA: Aleukemic myelogenous chloroma, Am. Jr. Dis. Child., 1932, xliv, 140. Google Scholar5. ROSENBLUM P: Chloroma, Jr. Pediat., 1933, ii, 59-67. CrossrefGoogle Scholar6. DOUBHARTMAN HPFW: Lymphocytic, myelocytic, and monocytic neoplasms, Jr. Am. Med. Assoc., 1935, cv, 942-948. CrossrefGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Birmingham, Michigan*Received for publication August 7, 1936. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 January 1937Volume 10, Issue 7Page: 1054-1061KeywordsBone marrowCellsMalignant tumors ePublished: 1 December 2008 Issue Published: 1 January 1937 PDF downloadLoading ...
Cardiac conduction defects associate with mutations in SCN5A
Authors: Jean-Jacques Schott, Connie Alshinawi, Florence Kyndt, Vincent Probst, Theo M. Hoorntje, Miriam Hulsbeek, Arthur A.M. Wilde, Denis Escande, Marcel M.A.M. Mannens, Hervé Le Marec
Journal: Nature Genetics (1999)
ESSENTIAL ORAL HYPERTHERMIA; REPORT OF A STUDY OF 25 CASES OF LOW GRADE 'FEVER'
Authors: Emanuel M. Rappaport
Journal: Annals of Internal Medicine (1946)

Article1 July 1946ESSENTIAL ORAL HYPERTHERMIA; REPORT OF A STUDY OF 25 CASES OF LOW GRADE 'FEVER'EMANUEL M. RAPPAPORTEMANUEL M. RAPPAPORTSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-25-1-1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThere are few problems confronting the internist more challenging, vexing and yet intriguing than fever which persists for weeks or months without yielding a single clue as to its origin. Not infrequently, time or the laboratory establishes the diagnosis. With the elapse of a sufficient period of observation, some leading symptom or clinical finding becomes manifest or one of the usually numerous laboratory tests enlisted in the search yields the clue to solution.The upper limit of normal oral temperature is almost universally regarded as 99° F. with rectal temperature one-half to three-quarters degree higher. Wright1accepts the range as...Bibliography1. WRIGHT AI: Textbook of Physiology, 1938, W. B. Saunders Co., Philadelphia. Google Scholar2. ROWNTREEKINTNER LGAR: Long-continued, low-grade idiopathic fever, Trans. Assoc. Am. Phys., 1934, xlvii, 60-69. Google Scholar3. WECHSLER IS: Cecil's Text-book of Medicine, 1941, W. B. Saunders Co., Philadelphia, p. 1654. Google Scholar4. EICHELBERG P: Durch Hypnose erzeugtes "Hysterisches Fieber," Deutsch. Ztschr. f. Nervenh., 1921, lxviii-lxix, 352-356. CrossrefGoogle Scholar5. POTOSKY C: Psychogenese and Psychotherapie von Organsymptomen beim Kinde. In: Q. SCHWARTZ, Psychogenese und Psychotherapie körperlicher Symptome, 1925, Springer, Wien, p. 385-424. CrossrefGoogle Scholar6. DEUTSCH F: Das psychogene Fieber, Med. Klin., 1926, xxii, 1213-1215. Google Scholar7. FRIEDMAN M: Etiology and pathogenesis of neuro-circulatory asthenia, War Med., 1944, vi, 221-227. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: M.C. A.U.S. Clinton, Iowa*Received for publication February 5, 1946.From the Medical Service, Schick General Hospital, Clinton, Iowa. Nextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byBody temperature and pulse rate in boys and young men prior to sporting contests. A study of emotional hyperthermia: With a review of the literatureREGULARLY PERIODIC FEVER OF ELEVEN YEARS‘ DURATION1 1 July 1946Volume 25, Issue 1Page: 1-14KeywordsFeversGrading of Recommendations Assessment Development and EvaluationHyperthermiaLaboratory testsMedical servicesResearch laboratoriesTemperature ePublished: 1 December 2008 Issue Published: 1 July 1946 Copyright & PermissionsCopyright, 1946, by The American College of PhysiciansPDF downloadLoading ...
Anatomically derived regional measurement of lung function
Authors: Michael Bennett, Tom Havelock, Joy Conway, John Fleming
Journal: European Respiratory Journal (2011)

Existing methods for quantifying lung ventilation and perfusion SPECT scans provide measurements which are either global, based on division of the lung into non-anatomical regions or based on the application of a generic lung model of lung anatomy. The objective of this work is to develop a technique to use HRCT data to automatically define sub-lobar regions corresponding to anatomical lung segments and to align these with SPECT/CT data acquired separately from the same subject. This can be achieved by performing a non-rigid registration between the HRCT data, acquired at full inspiration, and the low-res CT data captured as part of the SPECT procedure, acquired during tidal breathing. Once the transform required to bring these two data sets into alignment has been determined, it can be applied to the sub-lobar regions to map these to the low-res CT and hence to the SPECT data. This process of non-rigid registration is achieved using a free-form polynomial warp algorithm, which automatically determines the optimum elastic transform required to bring the HRCT and low-res CT data sets into alignment.  HRCT scans are analysed using commercially available software to define the airway tree geometry, which is then used to seed a Voronoi space division algorithm to divide the lung into segments based on the branches of the airway tree. Early results have shown that it is possible to robustly divide the lung into the regions based on the segmental branches of the airway tree and good alignment between single 2D slices and the SPECT images has been obtained.  The method will be extended to work in 3D and the results so far indicate that this will be a viable method to produce anatomically relevant measurements of lung function.
Abstract 1892: Electrocardiographic Manifestations of Sarcomere Mutations in Hypertrophic Cardiomyopathy: Incremental Value in the Prediction of Genetic Risk
Authors: Neal Lakdawala, Jens J Thune, Allison Cirino, Ole Havndrupm, Michael Christiansen, Henning Bundgaard, Calum A MacRae, Christian M Carlsen, Steven D Colan, Lars V Køber, Carolyn Y Ho
Journal: Circulation (2009)

Background: The diagnosis of hypertrophic cardiomyopathy (HCM) typically rests on identifying unexplained left ventricular hypertrophy (LVH) by cardiac imaging. Genetic testing can identify carriers of pathogenic sarcomere mutations (G+) prior to the development of LVH (G+/LVH−, preclinical HCM). Previous echocardiographic studies utilizing tissue Doppler imaging (TDI) have demonstrated impaired myocardial relaxation in this population; however electrocardiographic (ECG) findings, especially in relation to diastolic function, have not been well described in preclinical HCM. In the current study we describe the ECG features of sarcomeric HCM in the absence and presence of left ventricular hypertrophy (LVH). Methods: A genotyped cohort (n=217) consisting of 59 overt HCM (G+/LVH+), 77 preclinical HCM (G+/LVH−) and 81 normal control (G−/LVH−) subjects were studied with echocardiography and ECG. A subset also underwent cardiac magnetic resonance imaging (CMR). Comprehensive ECG analysis was performed blinded t...
The association between alcohol consumption and contact sensitization in Danish adults: the Glostrup Allergy Study
Authors: J.P. Thyssen, N.H. Nielsen, A. Linneberg
Journal: British Journal of Dermatology (2007)

Population-based epidemiological studies have indicated that alcohol consumption is associated with IgE-mediated immune diseases (i.e. allergic rhinitis, asthma and urticaria). These studies have been strongly supported by several immunological studies. Furthermore, an inhibitory effect of alcohol consumption on the development of delayed-type hypersensitivity has been shown in healthy controls. However, a possible association between contact sensitization and alcohol consumption in a general population has never been reported.To investigate whether alcohol consumption is associated with contact sensitization in a general population.In 1990, self-reported consumption of alcohol and patch testing results were assessed in 1112 subjects, aged 15-69 years, participating in a population-based cross-sectional study in Glostrup, Denmark. In 1998, they were invited to a follow-up and 734 were re-examined (participation rate 69.0%). Adjustment for potential confounders was performed by using logistic regression analyses.Women who reported no consumption of alcoholic drinks per week were more likely to develop contact sensitization (adjusted odds ratio 2.12, 95% confidence interval 0.98-4.61) during a 8-year follow-up period. A positive trend among women was detected (P=0.045).These data support the hypothesis that alcohol consumption leads to IgE-mediated immune responses rather than delayed-type hypersensitivity reactions. It is probable that alcohol consumption prevents the development of contact sensitization. Further epidemiological studies are warranted.