A METHOD FOR THE CONTINUOUS RECORDING OF GASTRIC pH IN SITU. IV. FURTHER EVALUATION OF THE EFFICACY OF ANTACIDS IN VITRO AND IN THE HUMAN BEING
Authors: N. E. Rossett, James Flexner
Journal: Annals of Internal Medicine (1943)

Article1 February 1943A METHOD FOR THE CONTINUOUS RECORDING OF GASTRIC pH IN SITU. IV. FURTHER EVALUATION OF THE EFFICACY OF ANTACIDS IN VITRO AND IN THE HUMAN BEINGN. E. ROSSETT, M.D., JAMES FLEXNER, M. D.N. E. ROSSETT, M.D.Search for more papers by this author, JAMES FLEXNER, M. D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-18-2-193 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptA method for the continuous recording of gastric pH in situ was recently described1, 2 and utilized in providing continuous pH recordings in vivo (dogs) and in vitro. Sodium bicarbonate, Sippy A powders, magnesium trisilicate, magnesium superoxol, and aluminum hydroxide were tested.3 The present communication deals with titrations in vitro and in the human stomach of these and other antacids commonly used in ulcer therapy.MATERIALS AND METHODSIn Vitro. Thirty c.c. of 0.1 normal hydrochloric acid and 70 c.c. of distilled water were placed in a beaker to represent the fasting contents (pH 1.4) of a hyperchlorhydric human stomach....References1. FLEXNERKNIAZUKNYBOER JMJ: Method for continuous recording of gastric pH in situ, Science, 1939, xc, 239. CrossrefGoogle Scholar2. FLEXNERKNIAZUK JM: A method for the continuous recording of gastric pH in situ. II. Experimental details, Am. Jr. Digest. Dis., 1940, vii, 138. CrossrefGoogle Scholar3. FLEXNERKNIAZUK JM: A method for the continuous recording of gastric pH in situ. III. Evaluation of the efficacy of certain antacids, Am. Jr. Digest. Dis., 1941, viii, 45. CrossrefGoogle Scholar4. VAN LIERESLEETH EJCK: The emptying time of the normal human stomach as influenced by acid and alkali, Am. Jr. Digest. Dis., 1940, vii, 118. CrossrefGoogle Scholar5. BLOOMFIELDCHENFRENCH ALCKLR: Basal gastric secretion as a clinical test of gastric function with special reference to peptic ulcer, Jr. Clin. Invest., 1940, xix, 863. CrossrefGoogle Scholar6. GARLIN C: Sécrétion gastrique provoquée par simple présence d'une sonde d'Einhorn dans les voies digestives, Bull. et mém. Soc. med. d. hôp. de Paris, 1929, liii, 984. Google Scholar7. HARDYQUANSTRON HHVE: Effect of gastric distension on gastric secretion, Proc. Soc. Exper. Biol. and Med., 1937, xxxvii, 28. CrossrefGoogle Scholar8. BRIDGESMATTICE MAMR: Over 2000 estimations of the pH of representative foods, Am. Jr. Digest. Dis., 1939, vii, 440. CrossrefGoogle Scholar9. MUTCH N: Synthetic magnesium trisilicate. Its action in the alimentary tract, Brit. Med. Jr., 1936, i, 205. CrossrefGoogle Scholar10. KOMEROVKOMEROV SAO: The precipitability of pepsin by colloidal aluminum hydroxide, Am. Jr. Digest. Dis., 1940, vii, 66. Google Scholar11. SCHIFFRINKOMEROV MJSA: The inactivation of pepsin by compounds of aluminum and magnesium, Am. Jr. Digest. Dis., 1941, viii, 215. CrossrefGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: New York, N. Y.*Received for publication October 6, 1941.From the Second (Cornell) Medical Division, Bellevue Hospital, and the Department of Medicine, Cornell Medical College. 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