PLASMOCHIN TOXICITY: ANALYSIS OF 258 CASES
Authors: Maurice Hardgrove, Irving L. Applebaum
Journal: Annals of Internal Medicine (1946)

Article1 July 1946PLASMOCHIN TOXICITY: ANALYSIS OF 258 CASESMAURICE HARDGROVE, IRVING L. APPLEBAUM, F.A.C.P.MAURICE HARDGROVESearch for more papers by this author, IRVING L. APPLEBAUM, F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-25-1-103 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptPlasmochin has had a checkered career in the rôle of an anti-malarial agent since it was first introduced into clinical medicine by Mühlens1in 1926. The literature is abundant with references which approximate 400 monographs and articles, but it is not within the scope of this paper to present a historical review. Although plasmochin was initially given a trial as the sole anti-malarial drug in various types of the disease, its usage gradually became limited. It has been employed for primary attacks of malaria in combination with quinine and atabrine; in blackwater fever when sensitivity to quinine was suspected; in...Bibliography1. MÜHLENS P: Die Behandlung der natürlichen menschlichen Malaria-infektion mit Plasmochin, Naturwissenschaften, 1926, xiv, 1162-1166. CrossrefGoogle Scholar2. CLARKKOMP HCW: A summary of ten years of observation on malaria in Panama with reference to control with quinine, atabrine, and plasmochin, without anti-mosquito measures, Human Malaria, Pub. No. 15, Am. Assoc. Adv. Sci., Washington, D. C., 1942, 273-284. Google Scholar3. GOODMANGILMAN LA: The pharmacological basis of therapeutics, The MacMillan Co., N. Y., 1941, page 917. Google Scholar4. EISELSBERG KP: Poisoning (plasmochin); 2 cases, Wien. klin. Wchnschr., 1927, xl, 525. Google Scholar5. NAMIKAWA H: Symptoms of poisoning in the treatment of malaria, Taiwan Igakkai Zasshi, 1928, cclxxxiv, 75. Google Scholar6. 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WESTHENDERSON JB: Plasmochin intoxication, Bull. U. S. Army Med. Dept.— number 82. November 1944, p. 87. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: *Received for publication November 1, 1945.From the Medical Service of Gorgas Hospital, Panama Canal Zone at the time Brig. Gen. Henry C. Dooling, U. S. A. was in charge. Field statistical data furnished by Col. W. C. Cox, M.C.; Lt. Col. S. J. Lerro, M.C.; and Capt. M. Vaughn, M.C. 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