tbuckley/cabot-search huggingface dataset:
Search for viruses in rheumatoid macrophage-rich synovial cell populations.
Authors: H Hart, M Norval
Journal: Annals of the Rheumatic Diseases (1980)

The adherent cells remaining after short-term culture of synovial fluid and synovial membrane cells from rheumatoid and non-rheumatoid patients were examined for the presence of a productive virus infection and for various viral antigens. Labelling was carried out with 3H-thymidine and 3H-uridine followed by sucrose density gradient centrifugation of the culture supernatant. Only in 1 case was there incorporation of 3H-uridine into material of density 1 . 21 g/cm3. Viral antigens were tested for by indirect immunofluorescence with antisera to rubella virus, the retroviruses RD-114 and simian sarcoma associated virus, early adenovirus type 2 antigens, late adenovirus type 2 antigens, SV-40 T antigen, and in 1 case measles virus. No cell showed immunofluorescence with any antiserum except the early adenovirus type 2 antiserum, which stained the cytoplasm of about half the synovial cell cultures, some from rheumatoid and some from non-rheumatoid patients.
Psychopharmacological Treatment of Major Depressive Disorder in Children and Adolescents
Authors: Christopher K. Varley
Journal: JAMA (2003)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Guidelines for dosimetry and calibration in ultraviolet radiation therapy: a report of a British Photodermatology Group workshop
Authors: D.K. Taylor, A.V. Anstey, A.J. Coleman, B.L. Diffey, P.M. Farr, J. Ferguson, S. Ibbotson, K. Langmack, J.J. Lloyd, P. Mccann, C.J. Martin, H.du P. Menage, H. Moseley, G. Murphy, S.D. Pye, L.E. Rhodes, S. Rogers
Journal: British Journal of Dermatology (2002)

Summary This report examines the dosimetry of ultraviolet (UV) radiation applied to dermatological treatments, and considers the definition of the radiation quantities and their measurement. Guidelines are offered for preferred measurement techniques and standard methods of dosimetry. The recommendations have been graded according to the American Joint Committee on Cancer classification of strength of recommendation and quality of evidence (summarized in Appendix 5).
TCT-57 Impact Of Coronary Artery Calcification On Clinical Events In Patients Undergoing Coronary Artery Bypass Grafting: Analysis From The ACUITY (Acute Catheterization And Urgent Intervention Triage Strategy) Trial
Authors: Konstanze Ertelt, Philippe Genereux, Gary S. Mintz, George R. Reiss, Ajay J. Kirtane, Mahesh V. Madhavan, Martin Fahy, Mathew Williams, Sorin Brener, Roxana Mehran, Gregg Stone
Journal: Journal of the American College of Cardiology (2013)
Prehospital Airway Management for Out-of-Hospital Cardiac Arrest
Authors: Michael Bernhard, Torben K. Becker, Bernd W. Böttiger
Journal: JAMA (2013)

To the Editor: Dr Hasegawa and colleagues1 studied different approaches to prehospital airway management (endotracheal intubation, supraglottic airway devices, and bag-valve-mask ventilation) in patients with out-of-hospital cardiac arrest (OHCA) in a Japanese cohort. The conclusion of the authors is in contrast to other evidence.
FURTHER OBSERVATIONS ON THE THERAPEUTICS OF THE CHLORID OF GOLD AND SODIUM.
Authors: CARL JOHN HABHEGGER
Journal: JAMA (1899)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Abstract P3-10-04: An Integration of Biological and Pathological Marker Panel in the TEAM Pathology Sub-Study: The Impact of Different Parameters on Risk Estimation of Relapse at Both 2.75 and 5 Years
Authors: JMS Bartlett, D Stocken, CJH van de Velde, CL Brookes, T Robson, A Hasenburg, ETM Hille, D Kiebeck, C Markopoulos, EA Mallon, L Dirix, FM Campbell, C Seynaeve, DW. Rea
Journal: Cancer Research (2010)

Abstract Background: Recent evidence confirms the importance of both biological and pathological risk markers in predicting early relapse for breast cancer patients treated with endocrine therapy. Most studies use a two step process integrating biological markers into a “biological predictor (e.g. Oncotype Dx, “IHC4” etc) followed by assessment of the predictive value of such tests in the context of pathological markers (grade, nodal status etc). We have taken a one step process integrating both biological and pathological markers into a single model to assess key factors for predicting outcome at 2.75 years and 5 years of endocrine therapy; to inform choices between switching, upfront and extended adjuvant treatment with AIs. Patients &amp; Methods: Pathology blocks from 4598 TEAM patients were collected and tissue microarrays constructed. Quantitative analysis ER, PgR, Ki67, HER1, HER2, and HER3 was performed centrally. A prognostic model, integrating data from biological and pathological markers was created to assess risk (disease-free survival) after 2.75 and 5 years of follow up in the TEAM trial. Results: Of 4595 eligible cases samples received, 16 were excluded, and 3993 had complete biomarker data for all markers for the final biomarker analysis. In univariate analysis nodal status, grade, size, age at diagnosis, HER1, HER2, PgR, ER and Ki67 were all prognostic. At 2.75 years nodal status, age, PgR histoscore, size, grade, HER2, ER histoscore and HER1 positivity were significant prognostic variables (ranked by WaldX2 statistic), Ki67 and HER3 were not included in this model. At 5 years median follow up; age, nodal status, size, PgR histoscore, grade, Ki67, HER2, and HER1 positivity were significant prognostic variables (ranked by WaldX2 statistic), ER and HER3 were not included in this model. Conclusion: Combined biological and pathological marker panels are of significant value in predicting early relapse in breast cancer patients treated with endocrine therapy, however duration of follow-up may impact on the inclusion of variables in the model. This provides significant information relevant to the choice of different adjuvant endocrine therapies. Citation Information: Cancer Res 2010;70(24 Suppl):Abstract nr P3-10-04.
Detection of Early Carcinoma of the Cervix in an Internist's Office
Authors: Maurige Fremont-Smith
Journal: New England Journal of Medicine (1958)

THIRTY-FIVE years ago I detected a hard, rough cervix in a woman of fifty-five. I sent her to Dr. Frank Pemberton, then the outstanding gynecologist in New England, and received the following report from him: "Only a specialist would be suspicious of the present appearance of the cervix.... This is an early case, and her chance of cure is better than usual." Four years later, at autopsy, she was found riddled with metastatic cancer.This story is indicative of the change during the past generation in the concept of early cancer. Thirty years ago a Stage 1 or even a . . .
Long-Term Survival Following Abdominal Aortic Aneurysmectomy
Authors: Arthur G. Baker
Journal: JAMA (1970)

Long-term results of resection of unruptured abdominal aortic aneurysms confirm the value of this operation. The conditions of 240 such patients from the Hospital of the University of Pennsylvania were followed up for a minimum of three years. Since the operative mortality has been consistently falling, the early high mortality figures unrealistically lower present long-term survival. Therefore, data including and excluding operative mortality were studied. For the entire series, the five- and ten-year survivals were 54% and 22%. For the 217 operative survivors, the percentages were 61% and 25%. These results appear to show a nearly doubled life expectancy of patients subjected to operation when compared to those not operated upon.
Dietary nitrate, nitric oxide, and restenosis
Authors: John P. Cooke, Yohannes T. Ghebremariam
Journal: Journal of Clinical Investigation (2011)

Endothelium-derived NO controls the contractility and growth state of the underlying vascular smooth muscle cells and regulates the interaction of the vessel wall with circulating blood elements. Acute injury of the vessel wall denudes the endothelial lining, removing homeostatic regulation and precipitating a wave of events leading to myointimal hyperplasia. In this issue of the JCI, Alef and colleagues provide evidence that in the injured vessel wall, the disruption of the NOS pathway is countered by induction of xanthine oxidoreductase, an enzyme capable of producing NO from nitrite. In addition, they link low dietary nitrite levels to increased severity of myointimal hyperplasia following vessel injury in mice.
Lung Herniation Evident on Lung Perfusion Images
Authors: GÜLGÜN BÜYÜKDERELİ, MUSTAFA KİBAR, SÜREYYA SOYUPAK
Journal: Clinical Nuclear Medicine (2000)

A 44-year-old woman who had tuberculosis treatment 6 years earlier and a pleural decortication operation of the right lung 2 years earlier was referred for perfusion lung imaging. This revealed decreased right lung volume with faint irregular perfusion and herniation of the left lung into the right hemithorax. To the authors’ knowledge, perfusion lung imaging showing herniation of one lung into the other hemithorax has not yet been described.
Disseminated Intravascular Coagulation During Rewarming Following Hypothermia
Authors: Suneel L. Mahajan
Journal: JAMA (1981)

DISSEMINATED intravascular coagulation (DIC) is a syndrome characterized by hemorrhage, thrombocytopenia, consumption of clotting factors, secondary fibrinolysis with elevated levels of fibrinogen-fibrin degradation products, microangiopathic hemolytic anemia, and fibrin thrombi in blood vessels.<sup>1</sup>This syndrome occurs in a variety of clinical conditions and is initiated by the liberation of tissue thromboplastin into the circulation, by vascular endothelial damage, by abnormalities of blood flow, or by all three.<sup>1</sup>Disseminated intravascular coagulation has been recognized as a complication of hypothermia in two series of neonatal infants<sup>2,3</sup>but has been reported in only one adult patient.<sup>4</sup>The present report describes a 13-year-old in whom DIC developed during the rewarming phase of accidental hypothermia. <h3>Methods</h3> The prothrombin time was determined using rabbit brain thromboplastin and the activated partial thromboplastin time was performed with a kaolin-activated reagent (Coag-A-Chek). Fibrinogen levels were measured using a standard thrombin reagent (Data-Fi) and fibrinogen determination
The Staging and Treatment of Hodgkin's Disease
Authors: Alan C. Aisenberg
Journal: New England Journal of Medicine (1978)

THE management of Hodgkin's disease remains a complex and evolving subject. Ten or even five years ago increasingly favorable survival rates based on increasingly aggressive radiation and chemotherapy would have been a reasonable prediction. Although there is no reason to question the validity of an optimistic attitude, it was not anticipated that radical treatment (particularly combined treatment with total nodal irradiation and multiagent chemotherapy) would carry substantial risks from serious sepsis and second neoplasms. Thus, a more conservative approach to Hodgkin's disease, tailoring treatment to the needs of the individual patient, is more appropriate in 1978 than it would have . . .
After the infarct.
Authors: P Bloomfield
Journal: BMJ (1987)

After the infarctThe patient with a myocardial infarction is likely to be admitted amid a flurry of activity to the unfamiliar environ- ment of an intensive care unit.After an enforced period of strict bedrest with a cardiac monitor emphasising his mortality he will be transferred to a general medical ward.But what then?"What should I do and not do now, doctor, and how can I prevent this happening to me again?" asks the patient.Booklets of advice for patients recovering from a myocardial infarction are widely available-for example, Back to Normal from the British Heart Foundation.Advice on what not to do is simple.Smokers should stop as stopping clearly reduces the risk of further infarction,' and the shock of a life threatening illness may help break the habit.Obese patients should aim at losing weight gradually, but stopping smoking should take priority.Diet is important in the minds of the public, but it has not been proved that a person reduces his chances of a second infarct by changing his diet.24All patients, but especially young ones, should have their serum cholesterol concentration measured, and ifthe value suggests familial hypercholesterolaemia then first degree relatives of the patient should also be investigated.Patients may drive after waiting two months but special rules apply to those with licences for heavy goods vehicles.5Patients who have had a myocardial infarct are generally encouraged to take regular exercise such as walking and to increase their activity gradually over a few weeks.They should be advised that they may feel fatigued for some days or weeks, especially if they have had a big infarct.More specific advice on what patients should be encouraged to do may be linked to assessing the severity of their disease.Patients may be encouraged to increase their physical activity within a formal rehabilitation programme.This may further restore confidence and patients may even achieve greater physical activity than they were used to before their infarction.Patients with desk jobs may return to work within four to six weeks, but those with more active jobs should take longer.The blocks to a full recovery may be more psychological than physical, and time should be set aside for simply talking to and listening to patients and their families.6Sexual intercourse should be avoided for six weeks, but the cardiovascular changes during intercourse are normally less than during an exercise test, which should reassure patients and their spouses.7
Significance of Bladder Neck Involvement on Progression in Superficial Bladder Cancer
Authors: Yasuhisa Fujii, Iwao Fukui, Kazunori Kihara, Toshihiko Tsujii, Kazuhiro Ishizaka, Yukio Kageyama, Satoru Kawakami, Hiroyuki Oshima
Journal: European Urology (1998)
Statistical Properties of Pulsatile Pressure and Flow in the Femoral Artery of the Dog
Authors: JAMES E. RANDALL
Journal: Circulation Research (1958)

Femoral pulsatile pressure and flow in anesthetized dogs were measured as time series. The computed cross products of pressure and flow were also expressed as time series. The statistical variance (ó 2 ) of each of these was analyzed into a frequency spectrum. The spectral magnitudes at each frequency were used to compute the pressure-flow coherence, impedance magnitude and phase angle as a function of frequency. The high coherency between pressure and flow at most frequencies indicated that a linear deterministic model may suffice to express the opposition to flow pulsations. The impedance variation with frequency indicated that the model may be frequency dependent. Computed autocorrelation and cross correlation functions measured the statistical nature of the observed time series.
Sleep disorders and melatonin rhythms in elderly people
Authors: I Haimov, M Laudon, N Zisapel, M Souroujon, D Nof, A Shlitner, P Herer, O Tzischinsky, P Lavie
Journal: BMJ (1994)

<h3>Background and aims</h3> The aim of this project was to introduce an innovative leadership programme aimed at hospice nurses within the community palliative care team to help enhance their leadership skills and build resilience to reduce the risk of burnout. The programme aimed to develop nursing leadership skills, to enhance patient care and to improve practitioner self-management. To ensure the programme reflects the needs of the individuals and the group as a whole, a range of teaching and learning methods were employed. The programme included Myers Briggs Type Indicator (MBTI), FIERCE training, training on self-management techniques and change, group coaching and a workbook which supported the programme with self-reflection exercises. The programme was underpinned by the Clinical Leadership Competency Framework (NHS Leadership Academy, 2011) to ensure optimisation of leadership potential. <h3>Method</h3> Focus groups were used to gather information from the participants regarding their understanding of leadership and how they felt about themselves as leaders. <h3>Results</h3> Prior to the programme participants felt that the traits of a leader and the relationship between leader and follower were of paramount importance. There was also an acknowledgement from the participants that they did not self-identify as leaders in their role. Following the leadership programme further focus groups were used to evaluate the programme. Participants felt they had increased their confidence around their leadership skills and the programme had helped them to understand themselves and others more which they felt led to better team working which consequently increased resilience. Questionnaires were also used to demonstrate change in individuals with most showing an improvement in their confidence, self-management and team working. <h3>Conclusion</h3> Overall, the evaluation of the leadership programme was extremely positive with the only suggested improvement to shorten the one-year programme to intensify the experience.
Heparin-binding EGF-like growth factor contributes to reduced glomerular filtration rate during glomerulonephritis in rats
Authors: Lili Feng, Gabriela E. Garcia, Young Yang, Yiyang Xia, Francis B. Gabbai, Orjan W. Peterson, Judith A. Abraham, Roland C. Blantz, Curtis B. Wilson
Journal: Journal of Clinical Investigation (2000)

Heparin-binding epidermal growth factor–like growth factor (HB-EGF), a member of the epidermal growth factor (EGF) family, is expressed during inflammatory and pathological conditions. We have cloned the rat HB-EGF and followed the expression of HB-EGF in rat kidneys treated with anti– glomerular basement membrane (anti–GBM) antibody (Ab) to induce glomerulonephritis (GN). We observed glomerular HB-EGF mRNA and protein within 30 minutes of Ab administration and showed by in situ hybridization that glomerular HB-EGF mRNA expression was predominantly in mesangial and epithelial cells. Expression of HB-EGF correlated with the onset of decreased renal function in this model. To test the direct effect of HB-EGF on renal function, we infused the renal cortex with active rHB-EGF, prepared from transfected Drosophila melanogaster cells. This treatment induced a significant decrease in single nephron GFR (SNGFR), single nephron plasma flow, and glomerular ultrafiltration coefficient and an increase in the glomerular capillary hydrostatic pressure gradient. In addition, anti–HB-EGF Ab administered just before anti-GBM Ab blocked the fall in SNGFR and GFR at 90 minutes without any change in the glomerular histologic response. These studies suggest that HB-EGF expressed early in the anti-GBM Ab GN model contributes to the observed acute glomerular hemodynamic alterations.
Colonizing the Body: State Medicine and Epidemic Disease in Nineteenth-Century India
Authors: D Armstrong
Journal: BMJ (1994)

David Arnold University of California Press, $18, pp 354 ISBN 0-520- 08295-8

The British Raj may have been the jewel in the crown of the empire but it had only slight impact on the everyday lives of most Indians. Similarly, Western medicine, as a component of the grand imperial project, also remained largely restricted to the enclaves of British political and cultural dominance such as the army, the prison, and the European settlement and had little effect on the overall health of India, at least before 1914. The medical …
Oculomotor Nerve Palsy as the Presenting Symptom of Gummatous Neurosyphilis and Human Immunodeficiency Virus Infection
Authors: Christopher W. Hess, Steven S. Rosenfeld, Stanley R. Resor
Journal: JAMA Neurology (2013)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Neurology HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Neurology journal
Preventing Gun Violence by Changing Social Norms
Authors: David Hemenway
Journal: JAMA Internal Medicine (2013)

Preventing Gun Violence by Changing Social NormsFrom a public health perspective, some social norms are beneficial (eg, washing your hands), while others are less so (eg, shaking hands, which may spread germs).Social norms can encourage or discourage violence.For example, traditional norms that men have a right to control women and that sexual violence is a private affair increase the likelihood of intimate partner violence.Social norms that encourage violence can be changed.