Recovery from Theophylline Toxicity by Continuous Hemodialysis with Filtration
Authors: Seiko Okada
Journal: Annals of Internal Medicine (2000)

Letters5 December 2000Recovery from Theophylline Toxicity by Continuous Hemodialysis with FiltrationSeiko Okada, MD, Shinji Teramoto, MD, and Rokuro Matsuoka, MDSeiko Okada, MDShowa General Hospital; Tokyo 187-8510, Japan (Okada)Sanno Hospital; Tokyo 107-0052, Japan (Teramoto)Showa General Hospital; Tokyo 187-8510, Japan (Matsuoka)Search for more papers by this author, Shinji Teramoto, MDShowa General Hospital; Tokyo 187-8510, Japan (Okada)Sanno Hospital; Tokyo 107-0052, Japan (Teramoto)Showa General Hospital; Tokyo 187-8510, Japan (Matsuoka)Search for more papers by this author, and Rokuro Matsuoka, MDShowa General Hospital; Tokyo 187-8510, Japan (Okada)Sanno Hospital; Tokyo 107-0052, Japan (Teramoto)Showa General Hospital; Tokyo 187-8510, Japan (Matsuoka)Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-133-11-200012050-00024 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:We describe an 83-year-old woman with chronic obstructive pulmonary disease (COPD) who was brought to our attention because of grand mal convulsion and deep unconsciousness.She presented with continual seizing and atrial fibrillation marked by a heart rate of 190 beats/min and hypotension. Computed tomography showed no lesion in the brain that would be responsible for refractory seizures. The plasma potassium level was 2.3 mmol/L, and the glucose level was 15.26 mmol/L (275 mg/dL). The serum theophylline level was 793 µmol/L.Charcoal hemoperfusion was initiated. After 3 hours of hemoperfusion, the theophylline level remained at 538 µmol/L. ...References1. Murciano D, Auclair MH, Pariente R, Aubier M. A randomized, controlled trial of theophylline in patients with severe chronic obstructive pulmonary disease. N Engl J Med. 1989;320:1521-5. CrossrefMedlineGoogle Scholar2. Huang D, O'Brien RG, Harman E, Aull L, Reents S, Visser J, et al . Does aminophylline benefit adults admitted to the hospital for an acute exacerbation of asthma? Ann Intern Med. 1993;119:1155-60. LinkGoogle Scholar3. Shannon M. Predictors of major toxicity after theophylline overdose. Ann Intern Med. 1993;119:1161-7. LinkGoogle Scholar4. Shannon MW. Comparative efficacy of hemodialysis and hemoperfusion in severe theophylline intoxication. Acad Emerg Med. 1997;4:674-8. CrossrefMedlineGoogle Scholar5. Forni LG, Hilton PJ. Continuous hemofiltration in the treatment of acute renal failure. N Engl J Med. 1997;336:1303-9. CrossrefMedlineGoogle Scholar Author, Article, and Disclosure InformationAffiliations: Showa General Hospital; Tokyo 187-8510, Japan (Okada)Sanno Hospital; Tokyo 107-0052, Japan (Teramoto)Showa General Hospital; Tokyo 187-8510, Japan (Matsuoka) PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoInflation of Precision in Medical Reports Glen L. Hortin Metrics Cited ByExtracorporeal treatment for theophylline poisoning: Systematic review and recommendations from the EXTRIP workgroupRenal Replacement TherapyExtracorporeal Treatment of PoisoningThe Role of Continuous Renal Replacement Therapy in the Treatment of PoisoningSuccessful Treatment of Acute Phenobarbital Intoxication by HemodiafiltrationCardiovascular Challenges in ToxicologyAdult Toxicology in Critical CareaExtracorporeal therapies for acute intoxicationsInflation of Precision in Medical ReportsGlen L. Hortin, MD, PhD 5 December 2000Volume 133, Issue 11Page: 922KeywordsAcute renal failureBlood plasmaCreatine kinaseEpileptic seizuresHemoperfusionMedical dialysisPlasma proteinsPotassiumTheophylline toxicityToxicity ePublished: 5 December 2000 Issue Published: 5 December 2000 CopyrightCopyright © 2000 by American College of Physicians. All Rights Reserved.PDF DownloadLoading ...