tbuckley/cabot-search huggingface dataset:
Abstract 3942: Cell death resistance promoted by radiotherapy in a colorectal cell line
Authors: Antuani R. Baptistella, Bruna Rodrigues, Marcos Dias, Fernanda Giudice, Tonielli Lacerda, Tiago Santos, Felipe Silva, Petrus Paulo Silva, Samuel Aguiar, Vilma Martins
Journal: Cancer Research (2014)

Abstract Colorectal adenocarcinoma is the fourth more frequent cause of death by cancer in the world. Despite some similarities, the rectal cancer has characteristics that differentiate it from the colon cancer, resulting in different treatments and outcomes. The rectal cancer in stages II and III is treated with neoadjuvant chemoradiation followed by surgery, and the response to neoadjuvant treatment in patients is variable and unpredictable. Up to now, surgery intervention is required to assess the pathologic response to therapy. The identification of predictive biomarkers for response to therapy is of great importance, in order to identify the patients that will benefit from such treatment. To better understand the molecular alterations in cells that resist to the radiotherapy, we started our research using WiDr, a colon tumor cell line. Cell cycle synchronized WiDr cells were submitted to two cycles of irradiation (4Gy in each cycle and 2 week of interval between the cycles) and resistant cells were isolated. Irradiated WiDr cells (RxTWiDr) shown a better capacity to form colonies, in colony growth assays, when compared to parental WiDr cells. This characteristic was maintained when they were submitted to a new round of irradiation. In addition, WiDrRxT cells treated with Staurosporine presented a higher viability in MTT assays than WiDr cells. We also collected the conditioned medium (CM) from RxTWiDr and WiDr cells, and treated the parental WiDr cells. The parental cells treated with CM from RxTWiDr cells for 15 minutes shown an increase in the ERK1/2 activation when compared to cells treated CM from WiDr cells. These results demonstrated that radio resistant cells are more resilient than parental cells and that their secreted factors activated specific signaling pathways via ERK1/2 phosphorylation. The nature of these factors is under investigation using proteomics. Supported by São Paulo State Foundation (FAPESP) Citation Format: Antuani R. Baptistella, Bruna Rodrigues, Marcos Dias, Fernanda Giudice, Tonielli Lacerda, Tiago Santos, Felipe Silva, Petrus Paulo Silva, Samuel Aguiar, Vilma Martins. Cell death resistance promoted by radiotherapy in a colorectal cell line. [abstract]. In: Proceedings of the 105th Annual Meeting of the American Association for Cancer Research; 2014 Apr 5-9; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2014;74(19 Suppl):Abstract nr 3942. doi:10.1158/1538-7445.AM2014-3942
Hematologic Malignancies With Extramedullary Spread of Disease
Authors: Nicola Giuliani, Cecilia Caramatti, Giovanni Roti, Antonella Geata, Simona Colla, Sabrina Bonomini, Magda Hojden, Silvia La Monica, Gabriella Sammarelli, Mirca Lazzaretti, Luisa Craviotto, Lina Mangoni, Vittorio Rizzoli
Journal: Journal of Clinical Oncology (2003)

Article Tools DIAGNOSIS IN ONCOLOGY Article Tools OPTIONS & TOOLS Export Citation Track Citation Add To Favorites Rights & Permissions COMPANION ARTICLES No companion articles ARTICLE CITATION DOI: 10.1200/JCO.2003.05.177 Journal of Clinical Oncology - published online before print November 1, 2016 PMID: 12721268 Hematologic Malignancies With Extramedullary Spread of Disease Case 1. Multiple Myeloma With Extramedullary Involvement of the Pleura and Testes Nicola GiulianixNicola GiulianiSearch for articles by this author , Cecilia CaramattixCecilia CaramattiSearch for articles by this author , Giovanni RotixGiovanni RotiSearch for articles by this author , Antonella GeataxAntonella GeataSearch for articles by this author , Simona CollaxSimona CollaSearch for articles by this author , Sabrina BonominixSabrina BonominiSearch for articles by this author , Magda HojdenxMagda HojdenSearch for articles by this author , Silvia La MonicaxSilvia La MonicaSearch for articles by this author , Gabriella SammarellixGabriella SammarelliSearch for articles by this author , Mirca LazzarettixMirca LazzarettiSearch for articles by this author , Luisa CraviottoxLuisa CraviottoSearch for articles by this author , Lina MangonixLina MangoniSearch for articles by this author , Vittorio RizzolixVittorio RizzoliSearch for articles by this author Show More Hematology, University of Parma, Parma, Italy https://doi.org/10.1200/JCO.2003.05.177 First Page Full Text PDF Figures and Tables © 2003 by American Society of Clinical Oncology
In search of the correct strategy for preventing the spread of HCV infection.
Authors: P Ruszniewski, D Malka, P Hammel, F Maire, P Rufat, I Madeira, F Pessione, P Lévy
Journal: Gut (2004)

In response to the letter of Harlozinska-Szmyrka and Strutynska-Karpinska ( Gut 2004; 53 :469–70) commenting on our study,1 we agree with the remarks made in relation to the difficulties in discriminating between chronic pancreatitis and adenocarcinoma using currently employed diagnostic imaging and tumour marker analysis. Our study was aimed at determining the risk of …
YAP1 in the hippo pathway influences the risk of asthma
Authors: Lili E. Fodor, Ildikó Ungvári, Orsolya Lautner-Csorba, Csaba Szalai
Journal: European Respiratory Journal (2013)

Asthma is an inflammatory disorder of the lungs. The main aim of this study was to identify new asthma susceptibility genes within the Hippo pathway. The Hippo pathway is responsible for organ size control, and surival and apoptosis of immune cells that play a role in asthma.  The expression of seven genes in the Hippo pathway was studied on RNA isolated from induced sputum of twenty asthmatics and twelve non-asthmatics. TaqMan gene expression assays were used to find a new gene to play a role in asthma. Furthermore, six, promoter region single nucleotide polymorphisms (SNPs) of YAP1 (Yes-associated protein 1) were genotyped on 110 asthmatics and 123 controls using KASPar genotyping, in order to find a susceptibility allele within this gene.  As a result, YAP1 gene expression levels were found to be significantly different between the two groups studied (p=0.044), hence indicating YAP1 as a novel gene in the Hippo pathway to play a role in asthma susceptibility. Additionally, correlation studies showed a significant positive correlation between YAP1 mRNA level and sputum macrophage percentages (p=0.034), which confirms that YAP1 gene expression increases in asthmatic progress, as well as the macrophage count increasing, leading to inflammation of the lungs in asthma. Additionally, YAP1 mRNA level also showed significant differences between the control, the mild asthmatic and the moderate to severe asthmatic groups (p=0.035). On the other hand, there were no significant differences in YAP1 SNP genotype counts between cases and controls.  To conclude, in this study a new gene was identified within the Hippo pathway that may play a role in asthma contributing to the existing knowledge on the pathogenesis of asthma.
Candida tropicalis bloodstream infection: Incidence, risk factors and outcome in a population-based surveillance
Authors: Mario Fernández-Ruiz, Mireia Puig-Asensio, Jesús Guinea, Benito Almirante, Belén Padilla, Manuel Almela, Ana Díaz-Martín, Jesús Rodríguez-Baño, Manuel Cuenca-Estrella, José María Aguado
Journal: Journal of Infection (2015)
P-111 Final results of the GIDEON (Global Investigational of therapeutic DEcisions in HCC and Of its treatment with sorafeNib) study according to patient etiology: The Italian experience
Authors: S. D'Angelo, D. Germano, T. Zolfino, D. Sansonno, G. Montalto, A. Benedetti, V. Montesarchio, A. Attili, A. Buonadonna, S. Barni, A. Gasbarrini, M. Pirisi, U. Cillo, S. Marenco, E. Villa, P. Giovanis, G. Pinotti, G. Raimondo, C. Erminero, M. De Giorgio, V. Lorusso
Journal: Annals of Oncology (2015)
Increasing difference in survival between women and men from 2001 to 2010: Data from the Danish oxygen register
Authors: Thomas Ringbaek, Christina Brinkved, Peter Lange
Journal: European Respiratory Journal (2013)

Objectives: To evaluate the changes over time in survival of COPD patients on long-term oxygen therapy (LTOT) in Denmark.

Setting: The Danish Oxygen Register, covering >99% of all Danish patients on LTOT.

Subjects: 14.967 COPD patients who started LTOT in the study period from 01.01.2001 to 31.12.2010.

Results: During the study period, the incidence of LTOT increased from 30.5 to 32.2 per 100,000. Mean age at start on LTOT was 74.0 (SD: 9.4), and 60.1% were females. Most of the patients (85.3%) started LTOT in connection with discharge after hospitalisation for an exacerbation. During the study, this proportion of patients increased from 76.5% to 91.7%.

The median survival was 1.5 years – better for females than males (1.69 versus 1.26 years; p<0.001) and better for patients who started LTOT from the outpatient clinic compared to patients who started LTOT after a hospitalisation (hazard ratio (95% CI): 0.85 (0.80-0.90). During the study period, the survival for all patients didn’t change (p=0.4), but the difference in survival between women and men increased significantly. The hazard ratios (95% CI) for men compared to women starting in 2001 was 1.16 (1.03-1.30) in 2001 versus 1.41 (1.22-1.63) in 2010; increasing 1.022 (1.007-1.037) per year, adjusted for start of LTOT after hospitalisation.

Conclusions: The difference in survival between women and men increased significantly from 2001 to 2010.
Simple Lateral Release in Treatment of Tennis Elbow
Authors: P T Calvert, I S Macpherson, R L Allum, G Bentley
Journal: Journal of the Royal Society of Medicine (1985)

The records of 340 patients with a clinical diagnosis of tennis elbow were surveyed and the results of conservative treatment assessed. Of 157 patients successfully treated by local steroid injections, 92% achieved their good result after one or two injections. Repeated injections were not helpful. Simple lateral release of the common extensor origin was carried out on 42 elbows in 37 patients. Thirty-seven elbows in 32 patients were personally reviewed. Satisfactory pain relief was achieved in 33 elbows (89%). There were no significant complications.
Relationship of vitamin D status with advanced liver fibrosis and response to hepatitis C virus therapy: A meta-analysis
Authors: Mónica García-Álvarez, Daniel Pineda-Tenor, María A. Jiménez-Sousa, Amanda Fernández-Rodríguez, María Guzmán-Fulgencio, Salvador Resino
Journal: Hepatology (2014)

There is growing evidence that vitamin D is related to chronic hepatitis C (CHC) pathogenicity. We analyzed the relationship of vitamin D status with advanced liver fibrosis (ALF) in CHC treatment-naïve patients and sustained virologic response (SVR) in CHC patients on pegylated interferon alpha plus ribavirin (pegIFNα/ribavirin) therapy. We performed a meta-analysis of all eligible studies published to date (April, 2014) in PubMed, SCOPUS, LILACS, and the Cochrane Library, assessing plasma/serum vitamin D levels related to ALF and/or SVR. Pooled odds ratios (ORs) were estimated by either fixed or random effects models. Fourteen studies were selected from the literature search, seven for ALF (1,083 patients) and 11 for SVR (2,672 patients). For liver fibrosis, low vitamin D status was related to a diagnosis of ALF, with the cutoffs of 10 ng/mL (OR=2.37, 95% confidence interval [CI]=1.20, 4.72) and 30 ng/mL (OR=2.22, 95% CI=1.24, 3.97) being significant, and a near-significance for 20 ng/mL (OR=1.44, 95% CI=0.99, 2.12). Regarding SVR, a significant heterogeneity among studies was found (P<0.001), and we only found a significant association with SVR for a vitamin D cutoff of 20 ng/mL (OR=0.53, 95% CI=0.31, 0.91). When meta-analysis was performed excluding the outliers, significant pooled ORs were found for all patients (10 ng/mL [OR=0.48, 95% CI=0.34, 0.67] and 20 ng/mL [OR=0.58, 95% CI=0.45, 0.76]) and GT1/4 patients (10 ng/mL [OR=0.53, 95% CI=0.34, 0.81] and 20 ng/mL [OR=0.54, 95% CI=0.39, 0.74]). Low vitamin D status in CHC patients is associated with a higher likelihood of having ALF and lower odds of achieving SVR following pegIFNα/ribavirin therapy.
The Uvulopalatopharyngoplasty Operation: The Edinburgh Experience
Authors: J F Sharp, M Jalaludin, JAM Murray, A G D Maran
Journal: Journal of the Royal Society of Medicine (1990)

The experience of the uvulopalatopharyngoplasty operation, performed on 24 patients for the relief of loud or heroic snoring, is presented. The operation successfully reduced the severity of snoring in 96% of patients. Postoperative complications were uncommon but included nasal regurgitation and intrapharyngeal adhesions in one patient. The role of the uvulopalatopharyngoplasty operation in the treatment of obstructive sleep apnoea is undecided but the authors do not perform this operation on such patients.
Abstract 5703: Up-regulation of miR-146a contributes to the inhibition of invasion of pancreatic cancer cells
Authors: Yiwei Li, Timothy VandenBoom, Zhiwei Wang, Dejuan Kong, Shadan Ali, Philip A. Philip, Fazlul H. Sarkar
Journal: Cancer Research (2010)

Abstract Pancreatic cancer (PC) is an aggressive malignancy with high mortality primarily due to its highly invasive and metastatic behavior. Over-expression of EGFR and activation of NF-κB are frequently observed in PC associated with high metastatic capacity. Emerging evidence also suggest the critical role of microRNAs (miRNAs) in the regulation of various biological and pathological processes including metastasis. Moreover, miR-146a has been found to be lost in metastatic prostate cancer and its expression reduces the metastatic potential of breast cancer cells through repression of IRAK1 (interleukin 1 receptor-associated kinase 1) and subsequent inhibition of NF-κB activity. In the present study, we assessed the expression pattern of miRNAs in the normal pancreatic duct epithelial cells and pancreatic cancer cells. We also investigated whether the treatment of PC cells with either B-DIM (BioResponse formulated 3,3′-diinodolylmethane with greater bioavailability) or G2535 (a mixture of genistein and other isoflavones) could alter the expression of miRNAs and their targets that are involved in the processes of invasion and metastasis. We found lower expression of miR-146a in PC cells compared to normal pancreatic duct epithelial cells. Interestingly, re-expression of miR-146a inhibited the invasive capacity of Colo357 and Panc-1 PC cells with concomitant down-regulation of EGFR and IRAK-1. Mechanistic studies including miR-146a re-expression, anti-miR-146 transfection, and EGFR knock-down experiment showed that there was a crosstalk between EGFR, MTA-2, IRAK-1, IκBα, and NF-κB. Most importantly, we found that the treatment of PC cells with B-DIM or G2535 could increase the expression of miR-146a and consequently down-regulated the expression of EGFR, MTA-2, IRAK-1, and NF-κB, resulting in the inhibition of invasion of Colo357 and Panc-1 cells. These results provide experimental evidence in support of the role of DIM and isoflavone as a potential non-toxic agent as regulators of miRNA, which could be useful for the inhibition of cancer cell invasion and metastasis, suggesting that these agents could be important for designing novel targeted strategy for the treatment of PC. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 101st Annual Meeting of the American Association for Cancer Research; 2010 Apr 17-21; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2010;70(8 Suppl):Abstract nr 5703.
Initial clinical trial of a selective retinoid X receptor ligand, LGD1069.
Authors: V A Miller, F M Benedetti, J R Rigas, A L Verret, D G Pfister, D Straus, M G Kris, M Crisp, R Heyman, G R Loewen, J A Truglia, R P Warrell
Journal: Journal of Clinical Oncology (1997)

PURPOSE The retinoid response is mediated by nuclear receptors, including retinoic acid receptors (RARs) and retinoid "X" receptors (RXRs). All-trans retinoic acid (RA) binds only RARs, while 9-cis RA is an agonist for both RARs and RXRs. Recently, LGD1069 was identified as a highly selective RXR agonist with low affinity for RARs. We undertook a dose-ranging study to examine the safety, clinical tolerance, and pharmacokinetics of LGD1069 in patients with advanced cancer. PATIENTS AND METHODS Fifty-two patients received. LGD1069 administered orally once daily at doses that ranged from 5 to 500 mg/m2 for 1 to 41 weeks. Treatment proceeded from a starting dose of 5 mg/m2. Pharmacokinetic sampling was performed on selected patients on days 1, 15, and 29. RESULTS Reversible, asymptomatic increases in liver biochemical tests were the most common dose-limiting adverse effect. Less prominent reactions included leukopenia, hypertriglyceridemia, and hypercalcemia. Characteristic retinoid toxicities, such as cheilitis, headache, and myalgias/arthralgias, were mild or absent. Two patients with cutaneous T-cell lymphoma experienced major antitumor responses. Pharmacokinetic studies obtained in 27 patients at eight dose levels showed that the day 1 area under the plasma concentration-times-time curves (AUCs) were proportional to dose. At all doses studied, the day 1 AUCs were similar to those on days 15 and 29, indicating a lack of induced metabolism. CONCLUSION LGD1069 is a unique compound that exploits a newly identified pathway of retinoid receptor biology that may be relevant to tumor-cell proliferation and apoptosis. Further investigation of this drug is warranted. Based on the results of this study, a dose of 300 mg/m2 is recommended for single-agent trials.
Vasopressin increases glomerular filtration rate in conscious rats through its antidiuretic action.
Authors: N Bouby, M Ahloulay, E Nsegbe, M Déchaux, F Schmitt, L Bankir
Journal: Journal of the American Society of Nephrology (1996)

To evaluate the possible influence of chronic alterations in urine concentrating activity (CA) on renal hemodynamics, adult male Sprague-Dawley rats were submitted for 7 days to one of three different levels of CA. CA was either reduced by increasing water intake (mixing the food with a gel bringing 1.6 mL water per g food) (Low-CA), or increased by chronic intraperitoneal infusion of 1-desamino 8-D-arginine vasopressin (200 ng/day) (High-CA). Low-CA, High-CA, and control rats were housed in metabolic cages, ate the same quantity of dry food (the amount provided being slightly lower than the spontaneous intake), and had free access to drinking water. The only difference between groups thus concerned the water intake-vasopressin axis. Radiolabeled (14C)inulin was infused chronically by osmotic minipumps. Urine was collected during Days 5, 6, and 7, and blood samples were taken for determination of plasma composition (P), absolute and fractional (FE) urinary excretion, and clearance (C) of inulin, creatinine, urea, and main electrolytes. This protocol produced mean 24-h urine osmolality (Uosm) ranging from 500 to 3500 mosmol/kg H2O without inducing any disturbance in body fluids or plasma osmolality (Posm). Results show that GFR (Cinulin) was markedly and positively correlated with Uosm (r = 0.798, P < 0.001) and free water reabsorption (r = 0.819, P < 0.001). For Uosm = 2500 mosm/kg H2O, GFR was 47% higher than for Uosm = 500 mosm/kg H2O. Ccreat underestimated GFR in High-CA and overestimated it in Low-CA. FEurea was inversely related to Uosm, as expected from the increased reabsorption known to occur at low urine flows. It is tentatively proposed that the intrarenal recycling of urea, triggered by vasopressin and essential to the urinary concentrating mechanism, might influence GFR indirectly by modifying the composition of the tubular fluid at the macula densa and thus the intensity of the tubuloglomerular feedback control of GFR. Even if this mechanism remains to be confirmed, this study unequivocally demonstrates, in normal conscious rats, that the level of urinary concentrating activity has a major influence on basal GFR.
Recurrent heterozygous missense mutation, p.Gly573Ser, in the TRPV3 gene in an Indian boy with sporadic Olmsted syndrome
Authors: J.E. Lai-Cheong, G. Sethuraman, M. Ramam, K. Stone, M.A. Simpson, J.A. McGrath
Journal: British Journal of Dermatology (2012)

Journal Article Recurrent heterozygous missense mutation, p.Gly573Ser, in the TRPV3 gene in an Indian boy with sporadic Olmsted syndrome Get access J.E. Lai‐Cheong, J.E. Lai‐Cheong St John's Institute of Dermatology, King's College London (Guy's Campus), London SE1 9RT, U.K Search for other works by this author on: Oxford Academic Google Scholar G. Sethuraman, G. Sethuraman Department of Dermatology, All India Institute of Medical Sciences, New Delhi, India Search for other works by this author on: Oxford Academic Google Scholar M. Ramam, M. Ramam Department of Dermatology, All India Institute of Medical Sciences, New Delhi, India Search for other works by this author on: Oxford Academic Google Scholar K. Stone, K. Stone St John's Institute of Dermatology, King's College London (Guy's Campus), London SE1 9RT, U.K Search for other works by this author on: Oxford Academic Google Scholar M.A. Simpson, M.A. Simpson Department of Molecular Genetics, King's College London (Guy's Campus), London SE1 9RT, U.K Search for other works by this author on: Oxford Academic Google Scholar J.A. McGrath J.A. McGrath St John's Institute of Dermatology, King's College London (Guy's Campus), London SE1 9RT, U.K John McGrath. E‐mail: john.mcgrath@kcl.ac.uk Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 167, Issue 2, 1 August 2012, Pages 440–442, https://doi.org/10.1111/j.1365-2133.2012.11115.x Published: 01 August 2012 Article history Accepted: 17 June 2012 Published: 01 August 2012
Interactions of Natural Effector Cells and Prostaglandins in the Control of Metastasis&lt;xref ref-type="fn" rid="FN2"&gt;2&lt;/xref&gt;
Authors: A M Fulton
Journal: JNCI Journal of the National Cancer Institute (1987)

The roles of prostaglandins and nonspecific immune effector cells were examined in the growth and metastasis of a series of murine mammary adenocarcinomas growing in BALB/c mice. The spontaneous metastasis of the highly metastatic tumor designated 410.4 was inhibited by oral administration of the prostaglandin synthesis inhibitor indomethacin (INDO), whereas treatment of mice with the interferon inducer polyinosinic-polycytidylic acid (poly I:C) delayed tumor growth but did not affect the rate of spontaneous metastasis. Lung colony formation was dramatically reduced by poly I:C treatment following iv tumor cell inoculation (experimental metastasis), whereas oral INDO had no significant effect. Suppression of natural killer cell activity with anti-asialo GM1 (asGM1) antibody increased lung colony-forming ability of mammary tumor lines with either high, moderate, or low metastatic capacity. Although pretreatment of the recipient with INDO did not alter the incidence of experimental metastasis, culture of the tumor cells with INDO (1 micron) prior to iv inoculation inhibited the appearance of lung colonies by greater than 90%. This beneficial effect was dependent on an asGM1-positive population. These results suggest that in this murine mammary tumor system, prostaglandin synthesis contributes to metastatic capacity and that the beneficial effects of INDO may be attributable, in part, to the enhancement of tumor cell sensitivity to natural cytotoxic effector mechanisms.