tbuckley/cabot-search huggingface dataset:
Purification and comparison of outer membrane protein P2 from Haemophilus influenzae type b isolates.
Authors: R S Munson, J L Shenep, S J Barenkamp, D M Granoff
Journal: Journal of Clinical Investigation (1983)

Haemophilus influenzae type b isolates have been subdivided based on differences in major outer membrane protein (OMP) profiles resolved on gradient and modified Laemmli sodium dodecyl sulfate-polyacrylamide gel electrophoresis systems. Although 21 subtypes have been observed, 86% of invasive isolates have one of five common subtypes and 71% of isolates have one of three subtypes. In isolates with two of the most common outer membrane subtypes, one major OMP has an apparent molecular weight of 37,000. In isolates with another common OMP subtype, a cross-reactive protein with an apparent molecular weight of 36,500 is observed. All three proteins have been designated P2. Protein P2 from these prototype isolates was solubilized with Zwittergent 3-14 and purified to homogeneity. Based on amino acid compositions, cyanogen bromide cleavage products, staphylococcal V8 protease, and chymotryptic peptide maps, the P2 protein from the three isolates has been highly conserved. Rabbit antibody prepared against P2 from one strain was cross-reactive with P2 isolated from the other two heterologous strains by Western blot. This antibody passively protected infant rats against type b Haemophilus infection caused by the homologous organism, but not against challenge by a strain with the heterologous 36,500 mol wt P2 protein. Thus, although the P2 protein from isolates with different OMP subtypes are closely related, the protection experiments suggest that determinants on the cell surface interacting with protective antibody may be strain or subtype specific.
Familial Clustering for Features of the Metabolic Syndrome
Authors: Weihong Tang, Yuling Hong, Michael A. Province, Stephen S. Rich, Paul N. Hopkins, Donna K. Arnett, James S. Pankow, Michael B. Miller, John H. Eckfeldt
Journal: Diabetes Care (2006)

OBJECTIVE—Metabolic syndrome–related traits (obesity, glucose intolerance/insulin resistance, dyslipidemia, and hypertension) have been shown to be genetically correlated. It is less clear, however, if the genetic correlation extends to novel risk factors associated with inflammation, impaired fibrinolytic activity, and hyperuricemia. We present a bivariate genetic analysis of MetS-related traits including both traditional and novel risk factors. RESEARCH DESIGN AND METHODS—Genetic correlations were estimated using a variance components procedure in 1,940 nondiabetic white individuals from 445 families in the National Heart, Lung, and Blood Institute (NHLBI) Family Heart Study. Twelve MetS-related traits, including BMI, waist circumference, blood pressure, white blood cell count, fasting serum triglycerides, HDL cholesterol, insulin, glucose, plasminogen activator inhibitor-1 antigen, uric acid, and C-reactive protein, were measured and adjusted for covariates, including lifestyle variables. RESULTS—Significant genetic correlations were detected among BMI, waist circumference, HDL cholesterol, triglycerides, insulin, and plasminogen activator inhibitor-1 antigen and between uric acid and all of the above variables except insulin. C-reactive protein and white blood cell count were genetically correlated with each other, and both showed significant genetic correlations with waist circumference and insulin. Fasting glucose was not significantly genetically correlated with any of the other traits. CONCLUSIONS—These results suggest that pleiotropic effects of genes or shared family environment contribute to the familial clustering of MetS-related traits.
Celebrities, charities, and complaints
Authors: Rhona MacDonald
Journal: BMJ (2004)

I n the current climate, where politician bashing is a popular sport and celebrities are worshipped as demigods, six leading UK charities (Data, Oxfam, Plan UK, Tearfund, Unicef UK, and WaterAid) came up with a cunning publicity stunt by praising the UK government through the words of top celebrities. However, they have been bashed a bit themselves as a result.

On 2 August, in a full page advertisement in the broadsheet the Independent , the six charities organised and funded an open thank you letter to the prime minister, Tony Blair, and the chancellor, Gordon Brown. The letter was signed by 15 UK and Irish celebrities, including Bono (lead singer of the rock group U2), film actor Jude Law, and film maker Richard Curtis.

The letter started off by saying “A big thank you” in large bold letters then continued, “It's unfashionable to congratulate politicians in public but we are going to anyway—to say thanks for increasing funds available to tackle world poverty now and for committing to reach the UN aid-giving target by 2013 at the latest.”

After praising them some more the letter finished, “We cannot stop here. In 2005 as chair …
“Minutes From Fishing and the Opera”
Authors: Robert A Edelstein
Journal: JAMA (2009)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Language for the Deaf
Authors: B. F. Nevile
Journal: BMJ (1937)

5-Fluorouracil (5-FU) cream was compared with podophyllin 25 percent in alcohol for treating genital and urethral condylomata acuminata. The cure rate after four weeks was found to be 6 of 18 patients treated with 5-FU and 10 of 19 treated with podophyllin. By changing the treatment for those not cured, warts regressed after four weeks in four more patients in each group. Patients were followed up for four to nine months; 10 of 27 treated with 5-FU and 14 of 31 treated with podophyllin remained in remission. It is not possible to support earlier reports on the successful treatment of meatal warts using 5-FU cream. More than half of the patients given 5-FU reported side effects after 10 to 14 days9 treatment, which in some cases led them to stop using the cream. Twenty-one men considered to be treatment failures or relapses were examined by urethroscopy. No intraurethral condylomata were found but three cases of warts in the fossa navicularis were doscovered; this prompted us to introduce an instrument to examine the urethral meatus and the fossa navicularis.
Copper vapour laser treatment of port wine stains: clinical evaluation and comparison with conventional argon laser therapy
Authors: R.A. SHEEHAN-DARE, J.A. COTTERILL
Journal: British Journal of Dermatology (1993)

Journal Article Copper vapour laser treatment of port wine stains: clinical evaluation and comparison with conventional argon laser therapy Get access R.A. SHEEHAN‐DARE, R.A. SHEEHAN‐DARE Department of Dermatology, The General Infirmary, Great George Street, Leeds LSI 3EX, U.K. Search for other works by this author on: Oxford Academic Google Scholar J.A. COTTERILL J.A. COTTERILL Department of Dermatology, The General Infirmary, Great George Street, Leeds LSI 3EX, U.K. Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 128, Issue 5, 1 May 1993, Pages 546–549, https://doi.org/10.1111/j.1365-2133.1993.tb00233.x Published: 01 May 1993 Article history Accepted: 16 December 1992 Published: 01 May 1993
Hypertension in children.
Authors: M. de Swiet, M. J. Dillon
Journal: BMJ (1989)

Empirical literature on value and growth style investing has found value style investing to be a favorable long-term investment strategy. However, value investing has lost its edge in the past 10–12 years. As a result, the value premium has been proclaimed dead by institutional investors who argue common valuation multiples, such as price to book, are not valid proxies for valuation. In this article we argue that the academic definition of value investing is structurally flawed. Common valuation multiples do not indicate mispricing (cheap vs. expensive) but rather investors’ discount rate, which is a denominator metric in valuation. We discuss the practical application of a new definition of value, and provide both theoretical and empirical evidence that a disruptive growth stock valuation premium exists in equity markets. We argue that in the past decade the valuation premium in growth stocks has been the main driver of their outperformance. <b>TOPICS:</b>Style investing, private equity, portfolio construction, equity portfolio management <b>Key Findings</b> • The academic definition of value investing has markedly underperformed for more than a decade. • In this article we argue that the under performance of value investing is a result of the lack of a valid asset pricing model. • We introduce a new definition of ‘value’ and a value premium that can be captured in all stocks, regardless whether stocks are classified as growth, value, large or small cap stocks.
Duncan's Diseases of Metabolism, vol 1: Genetics &amp;amp; Metabolism; vol 2: Endocrinology &amp;amp; Nutrition
Authors: Will G. Ryan
Journal: JAMA (1970)

Under Dr. Bondy's able new editorship the old and ailing<i>Duncan's Diseases of Metabolism</i>has undergone quite a face-lifting. In fact, except for the thyroid gland, it has undergone a total body transplant. Only two of the original authors have been retained. It has been divided into two volumes which makes for easier handling, as the previous edition had grown to be rather unwieldy. One volume is on genetics and metabolism and the other is on endocrinology and nutrition. Although the number of pages has been reduced, the content and range of subjects is considerably greater than the previous edition. This has been accomplished through a reduction in the size of type and a shift in emphasis on subjects covered. This edition, for instance, devotes about 100 pages to carbohydrate metabolism and its disorders, whereas in the previous edition there were almost 300. Thus it is a much more comprehensive
Observations on Effort Syndrome
Authors: J. D. Spillane
Journal: BMJ (1940)

BRITISH 739 certain that only in some cases of effort syndrome is hyperventilation an aetiological factor.Summary Fifty-two cases of effort syndrome have been hyper- ventilated.Only in 50% of them were clinical symptoms reproduLced in this way, and in these the symptoms were those which one commonly associates w.th tetany- e.g., paraesthesiae and disturbances of consciousnessrather than those characteristic of effort syndrome.We feel that in view of oUr findings we cannot suLpport the contentiotn of some workers that hyperventilaticn has an important place in the aetiology of effort syndrome.We wish to thank Dr.
Where Do Obituary Listings Come From? Putting the Matter to Rest
Authors: John S. Jaffe
Journal: JAMA (1994)

To the Editor.  —A cursory review of the Obituary Listing from JAMA , December 9, 1992, 1 reveals a puzzling phenomenon—the seeming disproportion of relatively young physicians.  I calculated the median age of death among the 40 deceased as 56.9 years. Is there any evidence this is part of a trend for physicians to die younger than the rest of the population?
ULTRASTRUCTURAL STUDIES OF HUMAN AND RABBIT αM-GLOBULINS
Authors: Björn Bloth, Bruce Chesebro, Sven-Eric Svehag
Journal: The Journal of Experimental Medicine (1968)

Electron micrographs of isolated human alpha(2)M-molecules, obtained by the negative contrast technique, revealed morphologically homogenous structures resembling a graceful monogram of the two letters H and I. The modal values for the length and width of the alpha(2)M particles were 170 A and 100 A, respectively. Purified rabbit alphamacroglobulins contained about 80% alpha(1)M- and 20% alpha(2)M-globulins. The isolated rabbit alpha(1)M- and alpha(2)M-molecules were morphologically indistinguishable from one another and from human alpha(2)M-molecules. Preliminary immunoprecipitation studies demonstrated that the two rabbit alphaM-globulins were antigenically different. Sedimentation constant determinations gave s(20, w) values of 18.8 and 18.2 for rabbit alpha(1)M and alpha(2)M, respectively.
Points from Letters: Double Cot Deaths
Authors: A. M. W. Porter
Journal: BMJ (1966)

that thoughtless minority who are out to claim all they can without concern for their doctor's discomfiture.Rather than embark on propaganda designed to prevent abuse of a tottering ser- vice I look forward to the day when a more positive approach becomes evident-namely, providing the general practitioner with the proper premises and facilities so badly needed to cope adequately with the sort of medicine required of him in this modern age.If distributing leaflets is the best that can be done I hope the planners find other means of so doing rather than through us.-Iam, etc., Resolven, Glam.
The role of high-density lipoproteins in the regulation of angiogenesis
Authors: Joanne T.M. Tan, Martin K.C. Ng, Christina A. Bursill
Journal: Cardiovascular Research (2015)

Angiogenesis is important for postnatal physiological processes including tissue neovascularization in response to an ischaemic injury. Conversely, uncontrolled inflammatory-driven angiogenesis can accelerate atherosclerotic plaque and tumour growth. Angiogenesis-associated diseases are highly prevalent globally, with cardiovascular-related disorders and cancer being the leading causes of mortality worldwide. A vast amount of research has been conducted on the vasculoprotective effects of high-density lipoproteins (HDLs) and while current HDL-raising therapies to date have not yielded the desired benefits clinically, its role in angiogenesis is yet to be fully elucidated. Epidemiological studies report positive correlations between elevated HDL levels and improved prognosis in both ischaemia- and inflammatory-driven pathologies, in which angiogenesis plays a key role. This review focuses on current evidence from epidemiological and prospective studies, coupled with animal models and mechanistic studies that highlight the ability of HDL to conditionally regulate angiogenesis.
The Causes of Colon Cancer-Reply
Authors: John D. Potter
Journal: JAMA (1993)

<h3>In Reply.</h3> —Dr Scott's letter captures nicely the complex nature of the etiology of colon cancer. My article suggested that more than fat and meat on the one hand and complex carbohydrates and fiber on the other are involved in the etiology. For instance, one needs to consider, inter alia, the genetically determined capacity to metabolize arylamines, the hepatic biliary response to fat ingestion, and the degree of anticarcinogenic activity in the colonic mucosa (whether exogenous via vegetables or endogenous via fermentation of fiber). Nonetheless, the net contribution of any of these will vary considerably from one culture to another—some where the increased risk is determined by the amount of carcinogens and promoters in the diet and where the endogenous protection against these compounds is sufficient to inhibit or reduce the likelihood of colon cancer; and others where the endogenous systems need a boost from external anticarcinogens or volatile fatty
Role of adhesion molecules in the development of massive hepatic necrosis in rats
Authors: S Mochida
Journal: Hepatology (1996)

Massive hepatic necrosis develops after endotoxin administration in rats pretreated with heat-killed Propionibacterium acnes as a result of microcirculatory disturbance caused by endothelial cell destruction by activated macrophages in the hepatic sinusoids. Immunohistochemical hepatic expression of intercellular adhesion molecule-1 (ICAM-1) and lymphocyte function-associated antigen 1 alpha (LFA-1 alpha) and the effect of monoclonal antibodies against both adhesion molecules on liver necrosis provoked after endotoxin administration was studied in these rats. There were increased stains of ICAM-1 in endothelial cells and LFA-1 alpha in macrophages in the hepatic sinusoids in Propionibacterium acnes-pretreated rats compared with normal rats. Such stains were further increased soon after endotoxin administration, followed by development of hepatic necrosis. Monoclonal antibodies against both adhesion molecules significantly attenuated the extent of liver injury compared with controls, without affecting the infiltration and activation of hepatic macrophages. Polyclonal antibodies against polymorphonuclear leukocytes eradicated circulating neutrophils, but did not change such liver injury, although gum arabic, which suppressed macrophage activation, attenuated the extent of liver injury. Thus, adhesion between endothelial cells and activated macrophages in the hepatic sinusoids via ICAM-1 and LFA-1 alpha is essential for the initiation of massive hepatic necrosis of this type. Contribution of neutrophils seems less likely.
Abstract 380: Magnetic nanoplatforms for tumor targeting, imaging and energy delivery
Authors: Srinivas Sridhar, Robert Campbell, Dattatri Nagesha, Evin Gultepe
Journal: Cancer Research (2011)

Abstract We have developed magnetic nano-liposomes (MNL), incorporating superparamagnetic iron oxide nanoparticles (SPION), that are versatile theranostic nanoplatform for enhanced drug delivery and monitoring of cancer treatment. MNL are prepared with a formuation of DPPC:DOTAP:CHOL and DOPE-PEG5000. Incorporation of SPIONs results in MNL with mean diameter of 150-250 nm. MNL are easily taken up by B16-F10 melanoma, HUMVEC-D and breast cancer cell lines. They preferentially target the tumor vasculature as shown in a dorsal skin fold chamber using fluorescently labeled MNL. MNL display superparamagnetic response that is essential for magnetic targeting, MR contrast enhancement and magnetic heating. MNL was administrated to SCID mouse with metastatic (B16-F10) melanoma grown in the right flank. Pre-injection and post-injection MR images were used to assess response to magnetic targeting effects. Biodistribution studies were conducted by 111In labeled MNL and amount of radioactivity recovered was used to confirm the effect of targeting for intratumoral administrations. We have shown that tumor signal intensities in T2 weighted images decreased an average of 20±5% and T2* values decreased and average of 14±7ms in the absence of magnetic targeting. This compares to an average signal decrease of 57±12% and a decrease in T2* relaxation times of 27±8ms with the aid of external magnet showing up to 2-fold greater accumulation by magnetic targeting. 111In radio-labeled MNL have been shown to enable multi-modal imaging in vivo using MRI and SPeCT/CT. The images show that an MNL bolus injected intra-tumorally was retained in the tumor 24 hours after injection. Application of a magnetic field enables redistribution of the MNL in the tumor. These MNL are also responsive to ac magnetic fields applied using a Copper coil at 360 kHz and 170A driving current. Both hyperthermia (upto 45C) and thermo-ablative temperatures upto 90C were achieved in 10 – 30 minutes ex vivo in buffer. The results indicate high efficiency for magnetic heating using MNL (Specific Absorption Rate ∼ 104 W/kg) and demonstrate the capability to couple ac magnetic fields to MNL to achieve any set of temperatures needed for hyperthermia and thermal ablation. To date there are no truly theranostic platforms that have been approved for clinical use that combine targeting, thermal heating and MRI imaging capabilities. Existing FDA approved magnetic nanoparticle formulations like ferridex and ferumoxytol, are optimized for MR imaging, and have not been shown to be usable for thermal therapy.The MNL platform is a novel nanoplatform combining multi-modal imaging capabilities, with magnetic targeting and thermal therapy. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 102nd Annual Meeting of the American Association for Cancer Research; 2011 Apr 2-6; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2011;71(8 Suppl):Abstract nr 380. doi:10.1158/1538-7445.AM2011-380
DIFFERENTIAL DIAGNOSIS BETWEEN ABDOMINAL TYPHOID AND APPENDICITIS BY MEANS OF IODIN REACTION. REPORT OF A CASE.
Authors: SIEGFRIED WEISS
Journal: JAMA (1900)

The clinical value of the iodin reaction of the blood has an established place among the clinical methods of examination since the investigations of Czerny, Livierato, Weiss and Goldberger. The following case will illustrate its value in the differential diagnosis between purulent perityphlitis and abdominal typhoid; The patient, H. N., is 9% years old. The mother died of pulmonary tuberculosis. A younger brother died of caries pedis. Two other sisters and the father of the patient are in good health. The child has had, until now, nothing but rubeola; the present illness began the last week in November, 1899. On the 25th of that month the child was troubled with cough, and on the 28th had a temperature of 38.3 C. She also complained of abdominal pains, which appeared spontaneously, like colic, and pressure on the abdomen did not seem to intensify the same. Along with it watery stools occurred,
Quality and Quantity: Synonyms or Antonyms?
Authors: Samuel Vaisrub
Journal: JAMA (1979)

Often juxtaposed in value judgments, life's quality and quantity bear an uneasy relationship to each other. Analyzing this relationship, Sisk<sup>1</sup>concludes that "clear disjunction between quality and quantity is possible only on a relatively high level of abstraction. Below that level, in the hectic stock exchange of quotidian life, quality and quantity are bewilderingly interrelated." In an affluent, consumer-oriented society, this interrelationship is so intimate that the two are almost synonymous. The quantity of material possessions becomes the measure of life's quality. By contrast, in societies or among persons with a stoic, ascetic outlook, quality and quantity are dialectic opposites. To Thoreau (<i>Walden</i>) plain living unencumbered with material goods was a prerequisite to the high thinking of a spiritually satisfying quality of life. Similarly, to the less philosophically minded dropouts of the 1960s, quantity of possessions and quality of life were antonymous rather than synonymous. While taking no issue
International maternal health indicators and middle-income countries: Russia
Authors: Justin O Parkhurst, Kirill Danischevski, Dina Balabanova
Journal: BMJ (2005)

<i>Maternal health outcomes for the countries of the former Soviet Union are poorer than for the rest of Europe. Russia in particular is a problem. What measures are suitable for guiding the country9s policy on improving this area of health care?</i>
Government rescues one London hospital
Authors: F Godlee
Journal: BMJ (1994)

The British government says that it will provide additional funding to save the University College London hospitals from closure and to ensure their long term future. The move comes after Camden and Islington Health Authority said that it planned to transfer contracts worth £20m ($30m) to other provider units. The secretary of state for health, Virginia Bottomley, said that the intervention was necessary to …