ACTH-PRODUCING PITUITARY TUMORS FOLLOWING ADRENALECTOMY FOR CUSHING'S SYNDROME
Authors: D H NELSON, J W MEAKIN, G W THORN
Journal: Annals of Internal Medicine (1960)

Article1 March 1960ACTH-PRODUCING PITUITARY TUMORS FOLLOWING ADRENALECTOMY FOR CUSHING'S SYNDROMED. H. NELSON, M.D., J. W. MEAKIN, M.D., G. W. THORN, M.D., F.A.C.P.D. H. NELSON, M.D., J. W. MEAKIN, M.D., G. W. THORN, M.D., F.A.C.P.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-52-3-560 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptSince describing a single patient who, following bilateral adrenalectomy for Cushing's syndrome associated with adrenal hyperplasia, subsequently developed an ACTH-producing tumor of the pituitary gland, we have had the opportunity to study or to determine plasma-ACTH levels on a total of nine other similar patients.1It is the purpose of this study to report one additional patient in detail, and to describe the clinical picture presented by these patients. Preliminary evidence concerning the therapy of this condition is also given. In none of the patients to be described was there evidence of a tumor of the pituitary gland prior to...Bibliography1. NelsonMeakin DHJW: A new clinical entity in patients adrenalectomized for Cushing's syndrome, J. Clin. Investigation 38: 1028, 1959. Google Scholar2. NelsonMeakinDealyMatsonEmersonThorn DHJWJBDDKGW: ACTH-producing tumor of the pituitary gland, New England J. Med. 259: 161, 1958. CrossrefMedlineGoogle Scholar3. NelsonHume DHDM: Corticosteroid secretion in adrenal venous blood of hypophysectomized dog as assay for ACTH, Endocrinology 57: 184, 1955. CrossrefMedlineGoogle Scholar4. BethuneNelsonThorn JEDHGW: Plasma adrenocorticotrophic hormone in Addison's disease and its modification by administration of adrenal steroids, J. Clin. Investigation 36: 1701, 1957. CrossrefMedlineGoogle Scholar5. Furth J: Experimental pituitary tumors, Recent Progress in Hormone Research 11: 221, 1955. Google Scholar6. DickieWooley MMGW: Spontaneous basophilic tumors of pituitary glands in gonadectomized mice, Cancer Research 9: 372, 1949. MedlineGoogle Scholar7. BehrensBromer OKWW: Biochemistry of the protein hormones, Ann. Rev. Biochem. 27: 57, 1958. CrossrefMedlineGoogle Scholar8. Bayliss RI: Section of Endocrinology: Cushing's syndrome with pituitary tumor and pigmentation, Proc. Roy. Soc. Med. 52: 256, 1959. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Boston, Massachusetts*Received for publication August 10, 1959.Presented in part at the Fifty-first Annual Meeting of the American Society for Clinical Investigation, Atlantic City, New Jersey, May, 1959.From the Department of Medicine, Harvard Medical School, and the Peter Bent Brigham Hospital, Boston, Massachusetts.†These investigations were supported in part by grants from the United States Public Health Service, Grant A-19 (C-9), and the John A. Hartford Foundation, Inc., New York, N. Y.‡Investigator, Howard Hughes Medical Institute.§Life Insurance Medical Research Fellow (1958-1959).Requests for reprints should be addressed to D. H. Nelson, M.D., Director, Metabolic Unit, Peter Bent Brigham Hospital, Boston 15, Massachusetts. 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MOORE, M.D., ROBERT G. DLUHY, M.D., GORDON H. WILLIAMS, M.D., JOHN P. 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Chirurgie der NebenniereAdrenalectomy for Lesions of the Adrenal GlandEndokrin bedingte EncephalopathienThe General Appearance (Habitus)Abnormalities of Neuroendocrine Functions in ManACTH-Bestimmungen im Plasma aus dem Bulbus cranialis venae jugularisCUSHING'S SYNDROME IN A YOUNG GIRLAdrenal Secretion After Bilateral Adrenalectomy for Cushing's SyndromeGEORGE P. KOZAK, M.D., GEORGE L. PAUK, M.D., ANTHONY I. VAGNUCCI, M.D., DAVID P. LAULER, M.D., GEORGE W. THORN, M.D., F.A.C.P.CUSHING'S SYNDROME WITH ADRENAL MEDULLARY INSUFFICIENCY AND ADRENAL AUTOANTIBODIESDISCUSSION OF THE PAPERSAn Unusual Case of Cushing's SyndromeObservations on some extra-adrenal effects of corticotropin on carbohydrate and lipid metabolism in manCushing's Syndrome and the HypophysisMultiple Endocrine Organ Refractoriness to Trophic Hormone Stimulation A Patient With an Enlarged Sella Turcica and Increased FSH SecretionSTEPHEN J. GORDON, M.D., ARNOLD M. MOSES, M.D.Hyperpigmentation and pituitary tumor as sequelae of the surgical treatment of Cushing's syndromePersistence of abnormal pituitary-adrenal relationship in patients with Cushing's disease partially corrected by bilateral subtotal adrenalectomyConcurrence of hyperplasia and neoplasia of the parathyroid glandsCushing's Syndrome Associated with Chromophobe Adenoma of the HypophysisKlinik und Differentialdiagnose des Cushing-SyndromsDie Therapie des Cushing-SyndromsTherapie des Cushing-Syndroms durch Implantation von Yttrium90 in die HypophyseCushing's syndromeCUSHING'S SYNDROME1�ber das Verhalten der endogenen ACTH-Aktivit�t im menschlichen Plasma nach enzymatischer Blockade der Cortisol-Synthese mit Metopiron (SU 4885)The adenohypophysisCushing's Syndrome Due to an ACTH-Secreting Chromophobe AdenomaThe Adrenal CortexCushing's Syndrome Associated with a Basophilic Carcinoma of the PituitaryBENJAMIN SIMKIN, M.D., JOEL F. PANISH, M.D., WILLIAM S. PALMER, M.D., SYLVAN COHEN, M.D.Surgical Physiology of HypertensionAdrenal Disorders I: Cushing's Syndrome and its PuzzlesMSH-Ausscheidung bei chemischer Nebennierenrinden-BlockadeManagement of Cushing's SyndromeMelanin PigmentationRECONSTITUTION OF FROZEN RED CELLSPITUITARY RESPONSE TO PYROGEN IN CUSHING'S SYNDROMEThe Role of Surgery in the Modern Treatment of HypertensionCUSHING'S SYNDROMEADRENOCORTICOTROPHIC ACTIVITY IN THE PLASMA OF PATIENTS WITH CUSHING'S SYNDROME ASSOCIATED WITH PULMONARY NEOPLASMSCHANGES IN FATTY-ACID COMPOSITION OF HUMAN AORTA ASSOCIATED WITH FATTY STREAKING 1 March 1960Volume 52, Issue 3Page: 560-569KeywordsAdrenalectomyAdrenocorticotropic hormoneBlood plasmaHospital medicineMedical servicesPatientsPituitary glandPituitary tumors ePublished: 1 December 2008 Issue Published: 1 March 1960 PDF downloadLoading ...