Screening for Vitamin D Deficiency
Authors: Toshihiro Sugiyama, Yoon Taek Kim, Hiromi Oda
Journal: Annals of Internal Medicine (2015)

Letters19 May 2015Screening for Vitamin D DeficiencyToshihiro Sugiyama, MD, PhD, Yoon Taek Kim, MD, PhD, and Hiromi Oda, MD, PhDToshihiro Sugiyama, MD, PhDFrom Saitama Medical University, Saitama, Japan.Search for more papers by this author, Yoon Taek Kim, MD, PhDFrom Saitama Medical University, Saitama, Japan.Search for more papers by this author, and Hiromi Oda, MD, PhDFrom Saitama Medical University, Saitama, Japan.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/L15-5094-3 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:LeBlanc and colleagues (1) conclude that treatment of vitamin D deficiency in asymptomatic adults might reduce the risk for falls but not fractures. This conclusion requires an explanation, because a fall is one of the strongest risk factors for a fracture. We present an evidence-based, mechanistic insight into this unexpected result.Muscle force is related to bone strength, and the risk reduction of falls but not fractures (1) theoretically means that treatment of vitamin D deficiency reduces fall risk by improving balance (rather than muscle force) but does not change fracture risk by impairing bone strength. The ...References1. LeBlanc ES, Zakher B, Daeges M, Pappas M, Chou R. Screening for vitamin D deficiency: a systematic review for the U.S. Preventive Services Task Force. Ann Intern Med. 2015;162:109-22. [PMID: 25419719] doi:10.7326/M14-1659 LinkGoogle Scholar2. Sugiyama T, Kim YT, Oda H. Osteoporosis therapy: a novel insight from natural homeostatic system in the skeleton. Osteoporos Int. 2015;26:443-7. [PMID: 25288445] doi:10.1007/s00198-014-2923-y CrossrefMedlineGoogle Scholar3. Sugiyama T, Torio T, Sato T, Matsumoto M, Kim YT, Oda H. Improvement of skeletal fragility by teriparatide in adult osteoporosis patients: a novel mechanostat-based hypothesis for bone quality. Front Endocrinol (Lausanne). 2015;6:6. [PMID: 25688232] doi:10.3389/fendo.2015.00006 CrossrefMedlineGoogle Scholar4. Sugiyama T, Yoshioka H, Sakaguchi K, Kim YT, Oda H. An evidence-based perspective on vitamin D and the growing skeleton. Osteoporos Int. 2015;26:1447-8. [PMID: 25448838] doi:10.1007/s00198-014-2975-z CrossrefMedlineGoogle Scholar5. Sugiyama T, Tanaka S, Miyajima T, Kim YT, Oda H. Vitamin D supplementation and fracture risk in adults: a new insight [Letter]. Osteoporos Int. 2014;25:2497-8. [PMID: 24989078] doi:10.1007/s00198-014-2798-y CrossrefMedlineGoogle Scholar Author, Article, and Disclosure InformationAuthors: Toshihiro Sugiyama, MD, PhD; Yoon Taek Kim, MD, PhD; Hiromi Oda, MD, PhDAffiliations: From Saitama Medical University, Saitama, Japan.Disclosures: Authors have disclosed no conflicts of interest. Forms can be viewed at www.acponline.org/authors/icmje/ConflictOfInterest Forms.do?msNum=L15-0122. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoScreening for Vitamin D Deficiency: A Systematic Review for the U.S. Preventive Services Task Force Erin S. LeBlanc , Bernadette Zakher , Monica Daeges , Miranda Pappas , and Roger Chou Screening for Vitamin D Deficiency: A Systematic Review for the U.S. Preventive Services Task Force Erin S. LeBlanc , Bernadette Zakher , Monica Daeges , Miranda Pappas , and Roger Chou Screening for Vitamin D Deficiency Mark J. Bolland , Andrew Grey , and Ian R. Reid Screening for Vitamin D Deficiency Kirti Kain Screening for Vitamin D Deficiency Erin S. LeBlanc , Roger Chou , and Miranda Pappas Screening for Vitamin D Deficiency Kirti Kain Screening for Vitamin D Deficiency Erin S. LeBlanc , Roger Chou , and Miranda Pappas Screening for Vitamin D Deficiency Mark J. Bolland , Andrew Grey , and Ian R. Reid Metrics Cited byVitamin D status and bone health in obesity: another mechanistic point of viewCalcium, proton pump inhibitors, and fracture risk 19 May 2015Volume 162, Issue 10Page: 737-738KeywordsBoneBone densityChildrenExerciseFallsMusclesSkeletonSpineVitamin DVitamin D deficiency ePublished: 19 May 2015 Issue Published: 19 May 2015 Copyright & PermissionsCopyright © 2015 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...