HEPATIC DAMAGE ASSOCIATED WITH SULFONAMIDE THERAPY IN INFANTS AND CHILDREN. I. MORPHOLOGIC PATHOLOGY
Authors: Maud L. Menten, Marie A. Andersch
Journal: Annals of Internal Medicine (1943)

Article1 October 1943HEPATIC DAMAGE ASSOCIATED WITH SULFONAMIDE THERAPY IN INFANTS AND CHILDREN. I. MORPHOLOGIC PATHOLOGYMAUD L. MENTEN, M.D., PH.D., F.A.C.P., MARIE A. ANDERSCH, PH.D.MAUD L. MENTEN, M.D., PH.D., F.A.C.P.Search for more papers by this author, MARIE A. ANDERSCH, PH.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-19-4-609 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe introduction of the sulfonamides into chemotherapy undoubtedly has reduced appreciably the mortality rate of many infections. However, certain untoward effects were not unexpected because of the inherent toxicity of these drugs and because of individual idiosyncrasy. A number of clinical reports have appeared regarding the deleterious effects of the sulfonamides on the hematopoietic system and the urinary tract. Toxic effects on the liver, as indicated by the development of jaundice, have been of less frequent occurrence. Varying degrees of pathologic change have been found by us in the liver of several infants and children dying during the course of...Bibliography1. HAGERMANBLAKE POFG: A febrile reaction to sulfanilamide; drug fever, Jr. Am. Med. Assoc., 1937, cix, 642-646. CrossrefGoogle Scholar2. SAPHIRSTEIN H: Hepatitis and toxic erythema with desquamation due to sulfanilamide, Urol. and Cutan. Rev., 1938, xxxxii, 101-102. Google Scholar3. LONG PH: The clinical use of sulfanilamide and its derivatives with special reference to their possible toxic effects, Jr. Ohio Med. Assoc., 1938, xxxiv, 977-981. Google Scholar4. BANNICKBROWNFOSTER EGAEFP: Therapeutic effectiveness and toxicity of sulfanilamide and several related compounds, Jr. Am. Med. Assoc., 1938, cxi, 770-777. CrossrefGoogle Scholar5. GARVIN CF: Toxic hepatitis due to sulfanilamide, Jr. Am. Med. Assoc., 1938, cxi, 2283-2285. CrossrefGoogle Scholar6. CLINE EW: Acute yellow atrophy of the liver following sulfanilamide medication, Jr. Am. Med. Assoc., 1938, cxi, 2384-2385. CrossrefGoogle Scholar7. FITZGIBBONSILVER PB: Necrosis of the liver (case) following use of sulfanilamide, California and West. Med. Jr., 1939, l, 123-125. Google Scholar8. LONGBLISSFEINSTONE PHEAWH: Mode of action and clinical use and toxic manifestations of sulfanilamide, Jr. Am. Med. Assoc., 1939, cxii, 115-121. CrossrefGoogle Scholar9. BERGERAPPLEBAUM SSHS: Toxic hepatitis due to sulfanilamide, Jr. Lab. and Clin. Med., 1940-1941, xxvi, 785-790. Google Scholar10. TRAGERMANGOTO LJJM: Fatal reactions to administration of sulfonamide drugs, Jr. Lab. and Clin. Med., 1939-1940, xxv, 1163-1176. Google Scholar11. SPRINGBERNSTEIN MI: Coexistence of toxic hepatitis, acute hemolytic anemia and renal damage following sulfanilamide therapy. Report of a case, ANN. INT. MED., 1940, xiv, 153-164. Google Scholar12. ROTHSTEINCOHN IS: Acute hemolytic anemia, auto-agglutination, toxic hepatitis and renal damage following sulfathiazole therapy, ANN. INT. MED., 1942, xvi, 152-162. Google Scholar13. HOYNELARIMORE ALGW: Sulfathiazole as a cause of death, Jr. Am. Med. Assoc., 1941, cxvii, 1354. Google Scholar14. LEDERERROSENBLATT MP: Death during sulfathiazole therapy, Jr. Am. Med. Assoc., 1942, cxix, 8-18. CrossrefGoogle Scholar15. CAREY BW: Use of sulfanilamide and related compounds in diseases of infancy and childhood, Jr. Am. Med. Assoc., 1940, cxv, 924-929. CrossrefGoogle Scholar16. GREINER K: Toxische Leberschädigung bei der Behandlung mit Sulfapyridin, Klin. Wchnschr., 1941, xx, 97-99. CrossrefGoogle Scholar17. MCINDOECOUNSELLOR AHVS: Bilaterality of liver, Arch. Surg., 1925, xv, 589-612. Google Scholar18. COPHERDICK GHB: Streamline phenomena in the portal vein and selective distribution of portal blood in the liver, Arch. Surg., 1928, xvii, 408-417. CrossrefGoogle Scholar19. EPPINGER H: Die Leberkrankheiten, 1937, Verlag von Julius Springer, Wien. CrossrefGoogle Scholar20. KESCHNERKLEMPERER HWP: Frequency and significance of hepatic edema, Arch. Path., 1936, xxii, 583-592. Google Scholar21. STILES MH: Hypersensitivity to small doses of sulfathiazole, Jr. Pennsylvania Med. Assoc., 1941, xxxxiv, 823-824. Google Scholar22. VOLINILEVITTO'NEIL IFROHB: Cutaneous and conjunctival manifestations of sulfathiazole intoxication, Jr. Am. Med. Assoc., 1941, cxvi, 938-940. CrossrefGoogle Scholar23. LYONSBALBEROR RHH: Febrile reactions accompanying the readministration of sulfathiazole, Jr. Am. Med. Assoc., 1942, cxviii, 955-958. CrossrefGoogle Scholar24. FRENCHWELLER AJCV: Interstitial myocarditis following clinical and experimental use of sulfonamide drugs, Am. Jr. Path., 1942, xviii, 109-122. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Pittsburgh, Pennsylvania*Received for publication June 29, 1942.From the Pathological Laboratories, University of Pittsburgh and Children's Hospital, Pittsburgh, Pennsylvania. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byDrug-Induced JaundiceCholangiolitic HepatitisSTREPTOMYCIN AND PROMIZOLE IN MILIARY TUBERCULOSIS AND TUBERCULOUS MENINGITIS IN CHILDREN 1 October 1943Volume 19, Issue 4Page: 609-621KeywordsAdverse reactionsChemotherapyChildrenDeath ratesInfantsLiverSulfonamideToxicity ePublished: 1 December 2008 Issue Published: 1 October 1943 PDF downloadLoading ...