tbuckley/cabot-search huggingface dataset:
Association Between rs1344706 of <i>ZNF804A</i> and Schizophrenia: A Meta-Analysis
Authors: Meiyan Zhu, Tongyang Liu, Jihong Zhang, Shuting Jia, Wenru Tang, Ying Luo
Journal: Genomics Proteomics & Bioinformatics (2014)

Abstract Schizophrenia is one of the most serious mental diseases found in humans. Previous studies indicated that the single nucleotide polymorphism (SNP) rs1344706 in the gene ZNF804A encoding zinc finger protein 804A was associated with schizophrenia in Caucasian population but not in Chinese Han population. However, current results are conflicting in Asian population. In the present study, a meta-analysis was performed to revisit the association between rs1344706 and the risk of schizophrenia in Asian, Caucasian and other populations. Electronic search of PubMed database identified 25 case–control studies with available genotype frequencies of rs1344706 for the meta-analysis, involving a total of 15,788 cases and 22,654 controls. A pooled odds ratio (OR) with 95% confidence interval (CI) was used to assess the association. The current meta-analysis showed an association between rs1344706 and schizophrenia in Caucasian populations (P = 0.028, OR = 1.138, 95% CI: 1.014–1.278; P = 0.004 for heterogeneity) and Asian populations (P = 0.008, OR = 1.092, 95% CI: 1.023–1.165; P = 0.001 for heterogeneity), but not in other populations (P = 0.286, OR = 1.209, 95% CI: 0.853–1.714, P = 0.120 for heterogeneity). Egger’s test (P &amp;gt; 0.05) and Begg’s test (P &amp;gt; 0.05) are both suggestive of the lack of publication bias for the included studies. Thus, the absence of association in other populations suggests a genetic heterogeneity in the susceptibility of schizophrenia and demonstrates the difficulties in replicating genome-wide association study findings regarding schizophrenia across different ethnic populations. To validate the association between rs1344706 and schizophrenia, further studies with larger participant populations worldwide are needed.
Year in review in Intensive Care Medicine, 2007. III. Ethics and legislation, health services research, pharmacology and toxicology, nutrition and paediatrics
Authors: Massimo Antonelli, Elie Azoulay, Marc Bonten, Jean Chastre, Giuseppe Citerio, Giorgio Conti, Daniel De Backer, François Lemaire, Herwig Gerlach, Johan Groeneveld, Goran Hedenstierna, Duncan Macrae, Jordi Mancebo, Salvatore M. Maggiore, Alexandre Mebazaa, Philipp Metnitz, Jerôme Pugin, Jan Wernerman, Haibo Zhang
Journal: Intensive Care Medicine (2008)
Candidate gene loci in asthmatic and allergic inflammation.
Authors: J. Wilkinson, S. T. Holgate
Journal: Thorax (1996)

New techniques for scanning the human genome promise great advances in tracking the origins of disorders caused by multiple genes. However, it is clear from the studies presented in this overview that we are far from understanding the genetic basis of asthma and atopy and their interaction with the environment. It is also clear that agreement must be reached on definition of the phenotype and methods of ascertainment in order to carry out large multicentre collaborative studies. Positive findings need to be validated in different populations selected for the presence of the disease and then confirmed in a random population where the prevalence of asthma and atopy will also be expected to be significant.
Biological washing powders as allergens
Authors: M. Flindt
Journal: BMJ (1995)

EDITOR,—A paper by me1 is cited by P J Rees in the reply to a query on whether biological washing powders might be a new allergen.2 Rees states that I reported late onset asthma in workers in factories producing these powders. In fact, the proteolytic enzyme was found to be a potent respiratory sensitiser, causing immediate and late asthma mediated by IgE in both atopic and non-atopic subjects, few of whom had had asthma …
Dioxin activates HIV-1 gene expression by an oxidative stress pathway requiring a functional cytochrome P450 CYP1A1 enzyme.
Authors: Y Yao, A Hoffer, C Y Chang, A Puga
Journal: Environmental Health Perspectives (1995)

We have studied the effect of several environmental chemicals on the transient expression of a chloramphenicol acetyltransferase (cat) reporter gene linked to the promoter sequences in the long terminal repeat (LTR) of the human immunodeficiency virus type 1 (HIV-1). Aflatoxin B1, 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD; dioxin) and benzo[a]pyrene cause a significant increases in CAT expression in mouse hepatoma Hepa-1 cells. The induction of CAT after TCDD treatment is abolished by administration of N-acetyl-L-cysteine or 2-mercaptoethanol and does not take place in a mutant cell line that lacks CYP1A1 enzymatic activity. Linker-scanning mutational analysis of transcription factor binding sites in the promoter revealed that both the NF kappa B and an adjacent aromatic hydrocarbon response element (AhRE) are required for TCDD-dependent CAT expression. In addition, mutation of the NFAT/AP-1 binding sites in the negative regulatory region of the promoter increases the magnitude of the TCDD effect. We conclude that induction of a functional CYP1A1 monooxygenase by TCDD stimulates a pathway that generates thiol-sensitive reactive oxygen intermediates which, in turn, are responsible for the TCDD-dependent activation of genes linked to the LTR. These data might provide an explanation for findings that TCDD increases infectious HIV-1 titers in experimental systems and for epidemiologic reports suggesting that exposure to aromatic hydrocarbons, such as found in cigarette smoke, is associated with an acceleration in AIDS progression.
A NEW TYPE OF SYRINGE, ESPECIALLY ADAPTED FOR INTRAVENOUS INJECTIONS OR THE ASPIRATION OF BLOOD
Authors: James Howard Brown
Journal: The Journal of Experimental Medicine (1918)

In rabbits destroying transfused blood constantly during a period of many months a pronounced and widespread siderosis ensues, practically identical with that characterizing human hemochromatosis. The findings do not indicate the ultimate cause of this disease, but they throw light on its various features and its course, and suggest a means for its diagnosis.
α<sub>1</sub>‐adrenergic stress induces downregulation of Na<sup>+</sup>/Ca<sup>2+</sup> exchanger in myocardial preparations from rabbits at physiological preload
Authors: Wolfgang Schillinger, Claus Christians, Samuel Sossalla, Nils Teucher, Phuc Nguyen Van, Harald Kögler, Oliver Zeitz, Gerd Hasenfuss
Journal: European Journal of Heart Failure (2007)
Asthma from aspirin.
Authors: E. L. Moll
Journal: BMJ (1969)

BEDICALJOURNAL(tetracycline and nystatin) was prescribed.The pain subsided, but the right scrotum started to swell.On arrival at hospital the boy did not com- plain of any pain in the scrotum.There was no history of any urinary trouble.His pulse was normal and his temperature 99 8°F. (37-7°C.).There was oedema of the right half of the scrotum, extending to the left side.The scrotum was extremely tender.The right testis was higher in the scrotum and no distinc- tion could be made out between it and the epididymis.The urine was normal chemically.A diagnosis of torsion was made and im- mediate operation carried out.Through a scrotal incision the testis was exposed and was found to be dark blue.There was high investment of the tunica vaginalis and torsion was intravaginal.As the testis did not improve after release of torsion, orchidectomy was done.The left testis was exposed at the same operation and high investment of the tunica vaginalis was found on this side too ; therefore orchidopexy was done.A histological report showed haemorrhagic infarct and necrotic spermatic tubules.
The Road Less Traveled
Authors: Robert E. McAfee
Journal: JAMA (1994)

I have had the opportunity to address many different audiences—both inside and outside the federation—and I have told many audiences how happy I was to be in this place or that, but I can't begin to tell you how honored I am to stand before you tonight, surrounded by so many familiar faces. It is a moment for the poets. Robert Frost writes, Two roads diverged in a wood, and I— I took the one less traveled by, And that has made all the difference. Frost's poem is about the choices that we make: what we choose, how we choose, and why we choose. But if the poem is about choosing, it is also about character. Something impels the poet to choose the road less traveled, just as something inside each of us in this room has impelled us to pursue the endless frontier that is medicine. Why did we
[762] ADMINISTRATION OF GRANULOCYTE COLONY-STIMULATING FACTOR (G-CSF) TO PATIENTS WITH ALCOHOLIC STEATOHEPATITIS (ASH) INDUCES CELL PROLIFERATION IN LIVER TISSUE: A PILOT STUDY
Authors: L. Spahr, J.-F. Lambert, L. Rubbia-Brandt, J.-L. Frossard, Y. Chalandon, E. Giostra, A. Hadengue
Journal: Journal of Hepatology (2007)
Association Study Of Genes Involved In Mast Cell Activation and Mnsaid-UA
Authors: Pedro Ayuso Parejo, Maria del Carmen Plaza-Serón, Inmaculada Doña, Natalia Blanca-López, Jose A. Cornejo-Garcia, Maria J. Torres, Javier Fernández, Jose Julio Laguna, Miriam Osorio, Veronique Godineau, Luisa Galindo, Cristobalina Mayorga, Gabriela Canto, Miguel Blanca
Journal: Journal of Allergy and Clinical Immunology (2014)
EGF Receptor As a Therapeutic Target: Patient Selection and Mechanisms of Resistance to Receptor-Targeted Drugs
Authors: C. L. Arteaga
Journal: Journal of Clinical Oncology (2003)

Emerging results from clinical trials of epidermal growth factor receptor (EGFR) inhibitors indicate good tolerability and at best modest to no clinical activity in a variety of human carcinomas. The lack of molecular evidence to suggest a pathogenic role for the EGFR in most common solid tumors is not inconsistent with the modest clinical activity observed in these single-agent trials. In addition, the lack of enrollment of patients with EGFR-dependent tumors onto these trials leaves open the possibility that these studies may have included some tumors that benefited from these therapies but for which this benefit was diluted and thus not detected within the enrolled patient population at large. These considerations suggest that the enrollment of unselected patients onto trials with EGFR inhibitors should be revisited to identify a cohort of EGFR-dependent tumors against which EGFR inhibitors might exhibit clinical activity. This approach would also exclude patients for whom these drugs will not induce any clinical benefit.
Lectures ON THE PASSAGE OF FOOD THROUGH THE HUMAN ALIMENTARY CANAL: Delivered at Guy's Hospital for London University Advanced Students during October, 1907
Authors: A. F. Hertz
Journal: BMJ (1908)

He had suffered from constipation for many years, and recently the pain and debility con- sequent on it had become distressing.In July, 1904, the ileum was divided and united to the sigmold.He improved greatly after the operation.Unfortunately he had acute obstructiou, and died in
485 IDENTIFICATION OF CCL20 AS A NOVEL MEDIATOR OF INFLAMMATION AND FIBROSIS IN ALCOHOLIC HEPATITIS
Authors: S. Affò, O. Morales-Ibanez, M. Moreno, J. Altamirano, P. Sancho-Bru, V. Arroyo, P. Ginès, J. Caballería, R. Bataller
Journal: Journal of Hepatology (2011)
Expression of the runt homology domain of RUNX1 disrupts homeostasis of hematopoietic stem cells and induces progression to myelodysplastic syndrome
Authors: Shinobu Matsuura, Yukiko Komeno, Kristen E. Stevenson, Joseph R. Biggs, Kentson Lam, Tingdong Tang, Miao-Chia Lo, Xiuli Cong, Ming Yan, Donna S. Neuberg, Dong-Er Zhang
Journal: Blood (2012)
392. Development of a New Lentiviral Vector for Site-Specific Integration into Mammalian Genomes
Authors: Angelo Lombardo, Michelle Calos, Luigi Naldini
Journal: Molecular Therapy (2005)

Gene therapy is an effective strategy for the correction of inherited immunodeficiencies. However, recently reported adverse events in one clinical trial have highlighted the risk of retroviral vector-mediated insertional mutagenesis in haematopoietic stem cells (HSC). For a gene therapy approach based on HSC, vector integration in target cell chromatin represents a necessary step to allow stable long-term transgene expression and its propagation to the cell progeny. Therefore, endowing lentiviral vector (LV) with site-specific integration would represent a major advance in the safety of integrating vectors.
Acetylcysteine and Speaking Tracheostomy Tubes
Authors: James P. Shinnick
Journal: JAMA (1981)

<h3>To the Editor.—</h3> The intubated patient cannot readily communicate his wants or express feelings. In 1975, Safar and Grenvik<sup>1</sup>introduced the speaking cuff tracheostomy tube in this country after an earlier design by Whitlock.<sup>2</sup>This new appliance allowed the long-term intubated patient with a tracheostomy to speak despite use of a ventilator. Basically, the instrument is a standard tracheostomy but with a second, narrowgauge tube (speaking tube) running along the outside and ending above the cuff. Compressed air or oxygen is delivered through the speaking tube and passes through the vocal cords. When phonation is attempted by the patient, words can be recognized. This is especially useful in the patient who cannot physically write or is illiterate. Unfortunately, this invention has not attained wide clinical use. We have noted and solved a mechanical problem that often causes these tubes to fail. Secretions may accumulate above the tracheostomy cuff
Sequential Immunization of Melanoma Patients with GD3 Ganglioside Vaccine and Anti-Idiotypic Monoclonal Antibody That Mimics GD3 Ganglioside
Authors: Paul B. Chapman, Dianna Wu, Govind Ragupathi, Sharon Lu, Linda Williams, Wen-Jen Hwu, Diantha Johnson, Philip O. Livingston
Journal: Clinical Cancer Research (2004)

Abstract GD3 ganglioside is an attractive target for immunotherapy of melanoma because it is abundantly expressed on all melanomas but not expressed on most normal tissues. Although GD3 has proven to be one of the least immunogenic gangliosides, our recent studies showed that anti-GD3 antibodies can be induced in patients immunized either with GD3-lactone-KLH (GD3-L-KLH) plus QS-21 adjuvant or with BEC2 anti-idiotypic monoclonal antibody vaccine, which mimics GD3, plus Bacillus Calmette-Guérin. We compared the immunogenicity of these two vaccines and tested whether one vaccine could prime an antibody response to the other. This is the first clinical trial immunizing patients with both antigen and anti-idiotypic monoclonal antibody vaccine. Twenty-four melanoma patients were randomized to be immunized with either BEC2 followed by GD3-L-KLH or in the opposite order. Our prior study suggested that a 25-μg dose of BEC2 was more immunogenic than our standard dose of 2.5 mg and therefor was used in this trial. Overall, 10 of 24 patients (42%) developed anti-GD3 antibodies detectable by ELISA, five in each cohort. All antibody responses were in response to the GD3-L-KLH vaccine. We found no evidence of priming by either vaccine. Antibody responses did not correlate with survival outcomes. Cellular responses were detected by enzyme-linked immunospot against BEC2, Bacillus Calmette-Guérin, and KLH, but not against GD3. We confirmed that GD3-L-KLH vaccine induces anti-GD3 antibodies, but we were unable to confirm our previous finding that a 25-μg dose of BEC2 is immunogenic. Future multivalent ganglioside vaccines should include the GD3-L-KLH vaccine.
OSHA Bloodborne Pathogens Standard Aims to Limit Occupational Transmission
Authors: Marsha F. Goldsmith
Journal: JAMA (1992)

PROTECTION of employees from infection with agents transmitted by blood, including but not limited to the hepatitis B virus (HBV) and the human immunodeficiency virus (HIV), is the goal of the new bloodborne pathogens standard promulgated by the Occupational Safety and Health Administration (OSHA), Washington, DC. The deadline for starting the information and training provision is tomorrow—June 4. And, by July 6, all employers of persons whose jobs can be "reasonably anticipated" to require contact with human blood and other potentially infectious materials must comply with the standard. Infectious materials (other than blood) as defined in the standard include semen, vaginal secretions, cerebrospinal fluid, synovial fluid, pleural fluid, pericardial fluid, peritoneal fluid, amniotic fluid, saliva in dental procedures (because it may contain blood), any body fluid visibly contaminated with blood, and all body fluids in situations where it is difficult or impossible to differentiate between body fluids. Urine and feces
Raised urea clearance in cirrhotic patients with high uric acid clearance is related to low salt excretion.
Authors: G Decaux, F Prospert, B Namias, M Schlesser, A Soupart
Journal: Gut (1992)

In cirrhotic patients without renal failure, salt retention could result from a decreased effective intravascular volume or could be a primary event leading to increased intravascular volume. Clearance of urea and uric acid depend on an effective intravascular volume. In the syndrome of inappropriate secretion of antidiuretic hormone (SIADH)--a state of increased intravascular volume--uric acid clearance is increased and that of urea is increased only when salt excretion is low. The intravascular volume of 60 consecutive cirrhotic patients without renal failure was estimated indirectly by studying the relationship between fractional excretion of filtered (FE) sodium, urea, and uric acid. Forty five per cent had a high FE uric acid (&gt; 12%), which could mean a high intravascular volume, and presented with an FE urea that was inversely correlated with FE sodium (r = 0, 62; p &lt; 0.001) as in SIADH, while in the controls the FE urea was positively correlated with FE sodium (r = +0, 46; p &lt; 0.01). In patients who had a normal FE uric acid and low FE sodium (&lt; 0.2%), the FE urea was significantly lower (40 (13)%, n = 20) than in subjects with high FE uric acid and a low FE sodium (61 (9)%, n = 16, p &lt; 0.001); this last group also presented with lower mean blood urea concentrations (3.1 (1.2) mmol/l and 4.0 (1.8) mmol/l; p &lt; 0.05) and a lower supine renin activity (p &lt; 0.01). As observed in the SIADH, cirrhotic patient with high FE uric acid have raised FE urea only when salt excretion is low. It is believed that the low salt excretion is not caused by a decrease in effective intravascular volume and that this is increased in cirrhotic patients with raised FE uric acid.
LONG-TERM OUTCOMES OF DIABETIC AND NON-DIABETIC PATIENTS FOLLOWING ENDOVASCULAR THERAPY FOR SUPERFICIAL FEMORAL ARTERY DISEASES
Authors: Junya Matsumi, Satoshi Takeshita, Shigeru Saito, Takeshi Akasaka, Yutaka Tanaka, Masato Murakami, Hidetaka Suenaga, Futoshi Yamanaka, Shingo Mizuno, Kazuya Sugitatsu
Journal: Journal of the American College of Cardiology (2012)
HARLOT plc: an amalgamation of the world's two oldest professions
Authors: D. L Sackett
Journal: BMJ (2003)

Tired of being good but poor, the authors have amalgamated the world's two oldest professions in a new niche company, HARLOT plc, specialising in How to Achieve positive Results without actually Lying to Overcome the Truth We've been good.DLS has prohibited sponsors' stockholders, much less employees, from seats on his data safety and monitoring boards and has enforced the banning of pharmaceutical reps from the medical wards at McMaster University.ADO has exposed problems with experts and has promulgated rigorous reviews of research to inform decisions about health care.In sum, we have established impeccable reputations for protecting the validity of randomised trials and systematic reviews, and for exposing lapses in methods, validity, therapeutic claims, and professional conduct.We've also been poor.DLS drives a clapped out pick-up truck, and his rowing boat leaks.ADO wears worn out blue jeans and hasn't had a new pair of shoes for 10 years.It has finally dawned on us that being good and being poor are causally related: being good doesn't pay.Accordingly, we have decided that it's time for us to find out whether being bad pays better.We're combining the world's oldest and second oldest professions, cashing in on our reputations, and distributing this confidential prospectus for our new company, HARLOT plc.Politics is money "[Politics is] the conduct of public affairs for private advantage."
Serial Transplantation and Long-term Engraftment of Intra-arterially Delivered Clonally Derived Mesenchymal Stem Cells to Injured Bone Marrow
Authors: Paul Lin, Diego Correa, Thomas J Kean, Amad Awadallah, James E Dennis, Arnold I Caplan
Journal: Molecular Therapy (2013)

It has been hypothesized that mesenchymal stem cells (MSCs) home to sites of injury. Nevertheless, efficient delivery of MSCs to target organs and description of their ultimate fate remain major challenges. We provide evidence that intra-arterially (IA) injected MSCs selectively engraft from the circulation as perivascular cells in the bone marrow (BM) after a localized radiation injury. Luciferase-expressing MSCs, derived from a conditionally immortalized clone (BMC-9) representing a pure population of cells, were arterially delivered into mice irradiated in one leg. Cell distribution was measured by bioluminescent imaging and final destination assessed by luciferase immunolocalization. IA injections resulted in engraftment only in the irradiated leg where cells localize and proliferate abluminal to the BM vasculature, a phenomenon not replicated with intravenous injections or with IA injections of kidney cells harvested from the same donor used for MSCs. Furthermore, MSCs harvested from the engrafted marrow and serially transplanted retain the ability to selectively engraft at sites of injury. This study demonstrates that MSCs can serially engraft at sites of injury from the circulation, that they reside in the perivascular space, and that arterial delivery is more efficient than venous delivery for cell engraftment.
P19INK4D links endomitotic arrest and megakaryocyte maturation and is regulated by AML-1
Authors: Laure Gilles, Romain Guièze, Dominique Bluteau, Véronique Cordette-Lagarde, Catherine Lacout, Rémi Favier, Fréderic Larbret, Najet Debili, William Vainchenker, Hana Raslova
Journal: Blood (2008)
Lichen Annulatus Serpiginosus
Authors: J. F. Payne
Journal: BMJ (1887)

We present a functional MRI experiment investigating the neural basis of feature-based attention in humans using the Stroop task. Cortical areas specifically involved in color processing and word reading were first identified in individual participants using independent tests. These areas were then probed during the Stroop task (in which participants must selectively attend to the font color of a word while ignoring the word itself). We found that activation in functionally defined color areas increased during the task relative to a neutral color-naming task while activation in functionally defined word areas decreased. These results are consistent with a biased competition model of feature-based attention in which the processing of attended features is enhanced and the processing of ignored features is suppressed.
Plasma levels of nitric oxide and related vasoactive factors following long-term treatment with angiotensin-converting enzyme inhibitor in patients with essential hypertension
Authors: Masakazu Kohno, Koji Yokokawa, Mieko Minami, Kenichi Yasunari, Kensaku Maeda, Hiroaki Kano, Takao Hanehira, Junichi Yoshikawa
Journal: Metabolism (1999)
Prophylactic Value of Dapsone in Leprosy
Authors: None Dharmendra
Journal: JAMA (1966)

ABSTRACT To the Editor:— For the past few years at the Chingleput Central Leprosy Teaching and Research Institute, we have been engaged in investigating the prophylactic value of treatment of healthy child contacts of open cases of leprosy with dapsone (diaminodiphenylsulfone). An interim report has just been published (Leprosy in India37 [Oct] 1965).This present analysis covers the results in 585 individuals of whom 291 belong to the prophylaxis group and 294 to a control group receiving placebo tablets in a doubleblind study. A period of 2 1/4 years is covered. The patients represent about 85% of the known contacts in a population of more than 2 million.The early results suggest that under the conditions of the investigation dapsone has a definite protective value against the disease.