tbuckley/cabot-search huggingface dataset:
Growth of the Lung Parenchyma Early in Life
Authors: Juan E. Balinotti, Christina J. Tiller, Conrado J. Llapur, Marcus H. Jones, Risa N. Kimmel, Cathy E. Coates, Barry P. Katz, James T. Nguyen, Robert S. Tepper
Journal: American Journal of Respiratory and Critical Care Medicine (2008)

Early in life, lung growth can occur by alveolarization, an increase in the number of alveoli, as well as expansion. We hypothesized that if lung growth early in life occurred primarily by alveolarization, then the ratio of pulmonary diffusion capacity of carbon monoxide (Dl(CO)) to alveolar volume (V(A)) would remain constant; however, if lung growth occurred primarily by alveolar expansion, then Dl(CO)/V(A) would decline with increasing age, as observed in older children and adolescents.To evaluate the relationship between alveolar volume and pulmonary diffusion capacity early in life.In 50 sleeping infants and toddlers, with equal number of males and females between the ages of 3 and 23 months, we measured Dl(CO) and V(A) using single breath-hold maneuvers at elevated lung volumes.Dl(CO) and V(A) increased with increasing age and body length. Males had higher Dl(CO) and V(A) when adjusted for age, but not when adjusted for length. Dl(CO) increased with V(A); there was no gender difference when Dl(CO) was adjusted for V(A). The ratio of Dl(CO)/V(A) remained constant with age and body length.Our results suggest that surface area for diffusion increases proportionally with alveolar volume in the first 2 years of life. Larger Dl(CO) and V(A) for males than females when adjusted for age, but not when adjusted for length, is primarily related to greater body length in boys. The constant ratio for Dl(CO)/V(A) in infants and toddlers is consistent with lung growth in this age occurring primarily by the addition of alveoli rather than the expansion of alveoli.
A surface impression and scanning electron microscopic study of porokeratosis of Mibelli
Authors: M.A. MENTER, P.B. FOURIE
Journal: British Journal of Dermatology (1977)

A silicone rubber impression technique, together with scanning electron microscopy, was used to study the surface detail of porokeratosis of Mibelli. The lesions are propagated by a bud-like spreading of the active edge. The keratotic rim is produced by the condensation of squamous cells from both within and without the lesion.
Occlusive ocular vascular disease and antiphospholipid antibodies.
Authors: C Tolosa-Vilella, J Ordi-Ros, R Jordana-Comajuncosa, A Selva-O'Callaghan, M Vilardell-Tarres
Journal: Annals of the Rheumatic Diseases (1990)

Letters to the editor weight' during the past three months.Physical examination disclosed a moderately ill woman.Skin and mucosae were pale.A 2-5 cm, indurated, slightly tender, not erythematous nodule was palpable in the right supra- clavicular region.Temporal arteries were not swollen, but the right one beat weakly.The rest of the physical examination was normal.
THE IMPACT OF PERMANENT PACEMAKER IMPLANTATION FOLLOWING TRANSCATHETER AORTIC VALVE REPLACEMENT ON OUTCOME
Authors: Marco Magalhaes Pereira, Sa'ar Minha, Ricardo Escarcega Alarcon, Nevin Baker, Hideaki Ota, Al Fazir Omar, Lakshmana Pendyala, Joshua Loh, Jose F. Rodriguez-Weisson, Rebecca Torguson, Fang Chen, Itsik Ben-Dor, Petros Okubagzi, William Suddath, Lowell Satler, Augusto Pichard, Ron Waksman
Journal: Journal of the American College of Cardiology (2014)
NOTES ON THE PATHOLOGY AND TREATMENT OF CHOLERA
Authors: J. R. Cormack
Journal: BMJ (1853)

SURGIrC ASSOCIATION was founded, there prevailed in the provinces strong feelings of distrust and jealousy of metro- politan physicians and surgeons.In fact, it was in no small degree owing to the arrogance of the London magnates, and to the depreciatory attitude which they assumed towards their provincial brethren, that so many rallied round our Association in its earlier years.The Provincial
Spectrum of ST-T–Wave Patterns and Repolarization Parameters in Congenital Long-QT Syndrome
Authors: Li Zhang, Katherine W. Timothy, G. Michael Vincent, Michael H. Lehmann, Jolene Fox, Lisa C. Giuli, Jiaxiang Shen, Igor Splawski, Silvia G. Priori, Steven J. Compton, Frank Yanowitz, Jesaia Benhorin, Arthur J. Moss, Peter J. Schwartz, Jennifer L. Robinson, Qing Wang, Wojciech Zareba, Mark T. Keating, Jeffrey A. Towbin, Carlo Napolitano, Aharon Medina
Journal: Circulation (2000)

Congenital long-QT syndrome (LQTS) is caused by mutations of genes encoding the slow component of the delayed rectifier current (LQT1, LQT5), the rapid component of the delayed rectifier current (LQT2, LQT6), or the Na(+) current (LQT3), resulting in ST-T-wave abnormalities on the ECG. This study evaluated the spectrum of ST-T-wave patterns and repolarization parameters by genotype and determined whether genotype could be identified by ECG.ECGs of 284 gene carriers were studied to determine ST-T-wave patterns, and repolarization parameters were quantified. Genotypes were identified by individual ECG versus family-grouped ECG analysis in separate studies using ECGs of 146 gene carriers from 29 families and 233 members of 127 families undergoing molecular genotyping, respectively. Ten typical ST-T patterns (4 LQT1, 4 LQT2, and 2 LQT3) were present in 88% of LQT1 and LQT2 carriers and in 65% of LQT3 carriers. Repolarization parameters also differed by genotype. A combination of quantified repolarization parameters identified genotype with sensitivity/specificity of 85%/70% for LQT1, 83%/94% for LQT2, and 47%/63% for LQT3. Typical patterns in family-grouped ECGs best identified the genotype, being correct in 56 of 56 (21 LQT1, 33 LQT2, and 2 LQT3) families with mutation results.Typical ST-T-wave patterns are present in the majority of genotyped LQTS patients and can be used to identify LQT1, LQT2, and possibly LQT3 genotypes. Family-grouped ECG analysis improves genotype identification accuracy. This approach can simplify genetic screening by targeting the gene for initial study. The multiple ST-T patterns in each genotype raise questions regarding the pathophysiology and regulation of repolarization in LQTS.
What is role of factor VIII therapy in inducing helper suppressor ratio reversals in hemophiliacs?
Authors: T. Hager
Journal: JAMA (1983)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Short-Term Statin Therapy Improves Cardiac Function and Symptoms in Patients With Idiopathic Dilated Cardiomyopathy
Authors: Koichi Node, Masashi Fujita, Masafumi Kitakaze, Masatsugu Hori, James K. Liao
Journal: Circulation (2003)

Chronic heart failure is associated with inflammation and neurohormonal imbalance. The 3-hydroxy-3-methylglutaryl-CoA (HMG-CoA) reductase inhibitors, or statins, exert anti-inflammatory and vascular protective effects. We hypothesized that short-term statin therapy may have beneficial effects in patients with nonischemic heart failure.Sixty-three patients with symptomatic, nonischemic, dilated cardiomyopathy were randomly divided into 2 groups. One group received simvastatin (n=24), and the other group received placebo (n=27). The initial dose of simvastatin was 5 mg/d, which was increased to 10 mg/d after 4 weeks. After 14 weeks, patients receiving simvastatin exhibited a modest reduction in serum cholesterol level compared with patients receiving placebo (130+/-13 versus 148+/-18, P<0.05). Patients treated with simvastatin had a lower New York Heart Association functional class compared with patients receiving placebo (2.04+/-0.06 versus 2.32+/-0.05, P<0.01). This corresponded to improved left ventricular ejection fraction in the simvastatin group (34+/-3 to 41+/-4%, P<0.05) but not in the placebo group. Furthermore, plasma concentrations of tumor necrosis factor-alpha, interleukin-6, and brain natriuretic peptide were significantly lower in the simvastatin group compared with the placebo group.Short-term statin therapy improves cardiac function, neurohormonal imbalance, and symptoms associated with idiopathic dilated cardiomyopathy. These findings suggest that statins may have therapeutic benefits in patients with heart failure irrespective of serum cholesterol levels or atherosclerotic heart disease.
A colourless conveyor belt?
Authors: R. Horton
Journal: BMJ (1996)

Paperback Writer? Ah, so perhaps LaPorte and Hibbitts's oracles were in favour of publishing after all. Still, the practice of (Ingel)fingering papers, whether in ink or in HTML, lives on as a curious relic of academic paternalism.* For who can doubt that authors have the right to distribute their research findings how they please? In medicine authors do not need an editor or an invidious “rule” to tell them of the …
Clonal immunoglobulin gene rearrangements in chronic lymphocytic leukemia: A correlative study
Authors: L. Soper, B. Bernhardt, A. Eisenberg, B. Cacciapaglia, L. Bennett, A. Sanda, M. Baird, R. Silver, P. Benn
Journal: American Journal of Hematology (1988)

Abstract Forty‐two patients with chronic lymphocytic leukemia (CLL) were studied for immunoglobulin gene and T‐cell receptor gene rearrangements. Immunoglobulin heavy chain gene rearrangements were demonstrable in 41 cases. One rearrangement of the T‐cell receptor beta chain gene was detected. Quantification of the relative intensities of germline and rearranged DNA bands suggests that a significant component of the lymphocytosis may be due to cell populations other than the malignant clonal population, particularly in earlier stages of the disease. A direct relationship was found between severity of disease and the relative amount of clonal immunoglobulin heavy chain gene rearrangement. Preliminary data for 12 patients followed sequentially indicated that clinical deteriorations or improvements are reflected in an increase or decrease, respectively, in the proportion of cells with rearranged immunoglobulin genes. Change in the relative proportion of cells with germline versus rearranged genes may provide an additional useful criterion for staging CLL, for more precisely defining the abnormal lymphocyte population, and for monitoring progression of the disease and efficacy of treatment.
Peptide functionalized poly(l-lysine)-g-poly(ethylene glycol) on titanium: resistance to protein adsorption in full heparinized human blood plasma
Authors: S. Tosatti, S.M.De Paul, A. Askendal, S. VandeVondele, J.A. Hubbell, P. Tengvall, M. Textor
Journal: Biomaterials (2003)
Comparison Of Rates Of Prescribing Oral Corticosteroids For Asthma Exacerbations Between Step-Down Therapy Approaches Among Initiators Of Inhaled Corticosteroids and Long-Acting Beta-Agonist Combination Therapy
Authors: Ayad K. Ali, Almut Winterstein, Leslie Hendeles, Xiaomin Lu, Richard Segal, Abraham Hartzema
Journal: Journal of Allergy and Clinical Immunology (2014)
Identification of a novel mutation in the polymerase delta 1 (POLD1) gene in a lipodystrophic patient affected by mandibular hypoplasia, deafness, progeroid features (MDPL) syndrome
Authors: Caterina Pelosini, Silvia Martinelli, Giovanni Ceccarini, Silvia Magno, Ilaria Barone, Alessio Basolo, Paola Fierabracci, Paolo Vitti, Margherita Maffei, Ferruccio Santini
Journal: Metabolism (2014)
Virtual Autopsy in the Intensive Care Unit
Authors: Carl M. Kirsch
Journal: Annals of Internal Medicine (2012)

Letters5 June 2012Virtual Autopsy in the Intensive Care UnitCarl M. Kirsch, MDCarl M. Kirsch, MDFrom Santa Clara Valley Medical Center, San Jose, CA 95128.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-156-11-201206050-00014 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:The concept of a virtual autopsy as presented by Wichmann and colleagues (1) is interesting, but there are some “abnormalities” of minor clinical significance that may be detected. Figure 3 in the article is said to show a right subclavian venous catheter inadvertently placed into the neck. The image shows that the course of the right-sided catheter is totally above the clavicle, thus suggesting that it actually is a right-sided internal jugular venous catheter. That the distal tip of the catheter was placed into the cervical portion of the internal jugular vein is not surprising or particularly ...Reference1. Wichmann D, Obbelode F, Vogel H, Hoepker WW, Nierhaus A, Braune S, et al. Virtual autopsy as an alternative to traditional medical autopsy in the intensive care unit: a prospective cohort study. Ann Intern Med. 2012;156:123-30. [PMID: 22250143] LinkGoogle Scholar Author, Article, and Disclosure InformationAuthors: Carl M. Kirsch, MDAffiliations: From Santa Clara Valley Medical Center, San Jose, CA 95128.Disclosures: None disclosed. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoVirtual Autopsy as an Alternative to Traditional Medical Autopsy in the Intensive Care Unit Dominic Wichmann , Frieder Obbelode , Hermann Vogel , Wilhelm Wolfgang Hoepker , Axel Nierhaus , Stephan Braune , Guido Sauter , Klaus Pueschel , and Stefan Kluge Virtual Autopsy in the Intensive Care Unit Dominic Wichmann and Stefan Kluge Metrics 5 June 2012Volume 156, Issue 11Page: 838-839KeywordsAutopsyCathetersComputed axial tomographyConflicts of interestIntensive care unitsJugular veinUltrasound imaging ePublished: 5 June 2012 Issue Published: 5 June 2012 Copyright & PermissionsCopyright © 2012 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Erythroblastosis Fetalis: Closing the Circle
Authors: John T. Queenan
Journal: New England Journal of Medicine (1986)

Today, many have the impression that the use of Rh immune globulin has eliminated the problem of erythroblastosis fetalis — that it is a danger we no longer need concern ourselves with. The facts are otherwise. Although Rh prophylaxis has been extremely effective in reducing the number of babies we see with this condition, some cases still occur. And when they do, it's a serious matter. In fact, this is an area of medicine in which our ability to prevent disease has run ahead of our ability to treat it.Now, treatment has taken a giant stride toward catching up. . . .
Cancer gene therapy by IL-12 gene delivery using liposomal bubbles and tumoral ultrasound exposure
Authors: Ryo Suzuki, Eisuke Namai, Yusuke Oda, Norihito Nishiie, Shota Otake, Risa Koshima, Keiichi Hirata, Yuichiro Taira, Naoki Utoguchi, Yoichi Negishi, Shinsaku Nakagawa, Kazuo Maruyama
Journal: Journal of Controlled Release (2009)
Focal adhesion kinase in netrin-1 signaling
Authors: Xiu-rong Ren, Guo-li Ming, Yi Xie, Yan Hong, Dong-mei Sun, Zhong-qiu Zhao, Zhu Feng, Qiang Wang, Sangwoo Shim, Zhou-feng Chen, Hong-jun Song, Lin Mei, Wen-cheng Xiong
Journal: Nature Neuroscience (2004)
Testicular Cancer after Treatment for Hodgkin's Disease
Authors: F Cavalli, H Fässler, S Kaplan, F Camponovo
Journal: New England Journal of Medicine (1980)

In Shasta Country, California an assessment was made of the hormone-binding status of malignant tissue removed from 28 mastectomy patients who smoked and 50 mastectomy patient who did not smoke. The tumors fo 68% of the nonsmokers were estrogen receptive positive while only 39% of the tumors from smokers were estrogen receptive positive (P .03). Lymph node metastases occurred among 50% of the smokers and only 32% of the nonsmokers (P 0.1). The tumors of 12 of the smokers an of an equal number of nonsmokers were assessed for progesterone receptive protein. Tumors of 8 of the nonsmokers and of only 1 of the smokers were progesterone receptive positive. Previous studies have demonstrated that malignant breast tumors which are estrogen receptive negative tend to reoccur sooner and to be less responsive to hormonal therapy than estrogen receptive positive tumors. These studies, in combination with the results of the present study, suggest ed that smokers with breast cancer may fare less well than nlnsmokers with breast cancer. Further research is needed to 1) clarify the nature of the observed relationship; 2) determine if smoking temporarily or permanently impairs the hormone-binding capacity of malignant cells; and 3) determine if smoking impairs the estrogen receptivity of nonmalignant cells.
Effect of vitamin K2 on the recurrence of hepatocellular carcinoma
Authors: Haruhiko Yoshida, Yasushi Shiratori, Masatoshi Kudo, Shuichiro Shiina, Toshihiko Mizuta, Masamichi Kojiro, Kyosuke Yamamoto, Yukihiro Koike, Kenichi Saito, Nozomu Koyanagi, Takao Kawabe, Seiji Kawazoe, Haruhiko Kobashi, Hiroshi Kasugai, Yukio Osaki, Yasuyuki Araki, Namiki Izumi, Hiroko Oka, Kunihiko Tsuji, Joji Toyota, Toshihito Seki, Toshiya Osawa, Naohiko Masaki, Masao Ichinose, Masataka Seike, Akihisa Ishikawa, Yoshiyuki Ueno, Kazumi Tagawa, Ryoko Kuromatsu, Shotaro Sakisaka, Hiroshi Ikeda, Hidekatsu Kuroda, Hiroyuki Kokuryu, Tatsuya Yamashita, Isao Sakaida, Tetsuo Katamoto, Kentaro Kikuchi, Minoru Nomoto, Masao Omata
Journal: Hepatology (2011)

Hepatocellular carcinoma (HCC) is characterized by frequent recurrence, even after curative treatment. Vitamin K2, which has been reported to reduce HCC development, may be effective in preventing HCC recurrence. Patients who underwent curative ablation or resection of HCC were randomly assigned to receive placebo, 45 mg/day, or 90 mg/day vitamin K2 in double-blind fashion. HCC recurrence was surveyed every 12 weeks with dynamic computed tomography/magnetic resonance imaging, with HCC-specific tumor markers monitored every 4 weeks. The primary aim was to confirm the superiority of active drug to placebo concerning disease-free survival (DFS), and the secondary aim was to evaluate dose-response relationship. Disease occurrence and death from any cause were treated as events. Hazard ratios (HRs) for disease occurrence and death were calculated using a Cox proportional hazards model. Enrollment was commenced in March 2004. DFS was assessed in 548 patients, including 181 in the placebo group, 182 in the 45-mg/day group, and 185 in the 90-mg/day group. Disease occurrence or death was diagnosed in 58, 52, and 76 patients in the respective groups. The second interim analysis indicated that vitamin K2 did not prevent disease occurrence or death, with an HR of 1.150 (95% confidence interval: 0.843-1.570, one-sided; P = 0.811) between the placebo and combined active-drug groups, and the study was discontinued in March 2007. Conclusion: Efficacy of vitamin K2 in suppressing HCC recurrence was not confirmed in this double-blind, randomized, placebo-controlled study. (Hepatology 2011;)
Synergistic Effect of β-Amyloid and Neurodegeneration on Cognitive Decline in Clinically Normal Individuals
Authors: Elizabeth C. Mormino, Rebecca A. Betensky, Trey Hedden, Aaron P. Schultz, Rebecca E. Amariglio, Dorene M. Rentz, Keith A. Johnson, Reisa A. Sperling
Journal: JAMA Neurology (2014)

Assessing the ability of Alzheimer disease neuroimaging markers to predict short-term cognitive decline among clinically normal (CN) individuals is critical for upcoming secondary prevention trials using cognitive outcomes.
A CONDITION SOMEWHAT RESEMBLING LUPUS PERNIO IN A CHILD
Authors: F. PARKES WEBER
Journal: British Journal of Dermatology (1921)

Journal Article A CONDITION SOMEWHAT RESEMBLING LUPUS PERNIO IN A CHILD Get access F. PARKES WEBER, M.A., M.D., F.R.C.P. F. PARKES WEBER, M.A., M.D., F.R.C.P. Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology and Syphilis, Volume 33, Issue 6, 1 June 1921, Pages 228–233, https://doi.org/10.1111/j.1365-2133.1921.tb09040.x Published: 01 June 1921
Global, regional, and national consumption levels of dietary fats and oils in 1990 and 2010: a systematic analysis including 266 country-specific nutrition surveys
Authors: R. Micha, S. Khatibzadeh, P. Shi, S. Fahimi, S. Lim, K. G. Andrews, R. E. Engell, J. Powles, M. Ezzati, D. Mozaffarian
Journal: BMJ (2014)

To quantify global consumption of key dietary fats and oils by country, age, and sex in 1990 and 2010.Data were identified, obtained, and assessed among adults in 16 age- and sex-specific groups from dietary surveys worldwide on saturated, omega 6, seafood omega 3, plant omega 3, and trans fats, and dietary cholesterol. We included 266 surveys in adults (83% nationally representative) comprising 1,630,069 unique individuals, representing 113 of 187 countries and 82% of the global population. A multilevel hierarchical Bayesian model accounted for differences in national and regional levels of missing data, measurement incomparability, study representativeness, and sampling and modelling uncertainty.Global adult population, by age, sex, country, and time.In 2010, global saturated fat consumption was 9.4%E (95%UI=9.2 to 9.5); country-specific intakes varied dramatically from 2.3 to 27.5%E; in 75 of 187 countries representing 61.8% of the world's adult population, the mean intake was <10%E. Country-specific omega 6 consumption ranged from 1.2 to 12.5%E (global mean=5.9%E); corresponding range was 0.2 to 6.5%E (1.4%E) for trans fat; 97 to 440 mg/day (228 mg/day) for dietary cholesterol; 5 to 3,886 mg/day (163 mg/day) for seafood omega 3; and <100 to 5,542 mg/day (1,371 mg/day) for plant omega 3. Countries representing 52.4% of the global population had national mean intakes for omega 6 fat ≥ 5%E; corresponding proportions meeting optimal intakes were 0.6% for trans fat (≤ 0.5%E); 87.6% for dietary cholesterol (<300 mg/day); 18.9% for seafood omega 3 fat (≥ 250 mg/day); and 43.9% for plant omega 3 fat (≥ 1,100 mg/day). Trans fat intakes were generally higher at younger ages; and dietary cholesterol and seafood omega 3 fats generally higher at older ages. Intakes were similar by sex. Between 1990 and 2010, global saturated fat, dietary cholesterol, and trans fat intakes remained stable, while omega 6, seafood omega 3, and plant omega 3 fat intakes each increased.These novel global data on dietary fats and oils identify dramatic diversity across nations and inform policies and priorities for improving global health.
"DEFICIENT EXCRETION FROM KIDNEYS NOT ORGANICALLY DISEASED AND SOME OF THE DISEASES PECULIAR TO WOMEN," AND DISEASES OF THE SKIN.
Authors: L. DUNCAN BULKLEY
Journal: JAMA (1898)

One year ago Dr. James H. Etheridge of Chicago, by invitation, made an address before this Society, the title of which was the first portion of that above given.<sup>1</sup>As there was no discussion except some remarks by the present writer it seemed best to present the matter again, with the author's full consent, in hopes that the important subject might receive further consideration from the members present, and that it might thus become doubly impressed on those likely to meet the cases referred to. While the present writer disclaims all special knowledge in regard to diseases peculiar to women, he feels particularly interested in the subject which Dr. Etheridge so ably presented, for several reasons. Incidentally he has met many female patients, coming under treatment for various diseases of the skin, who were known to have also various uterine disorders of distressing character. Many of these patients had