Molecular Mechanisms of Antibiotic Action
Authors: W Carter, K S McCarty
Journal: Annals of Internal Medicine (1966)

Review1 May 1966Molecular Mechanisms of Antibiotic ActionWILLIAM CARTER, M.D., KENNETH S. MCCARTY, PH.D.WILLIAM CARTER, M.D.Search for more papers by this author, KENNETH S. MCCARTY, PH.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-64-5-1087 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptOUTLINE*I. IntroductionII. Review of the molecular mechanisms of replication, information transfer, and protein synthesisIII. Antibiotics which modify the molecular mechanisms of replication, information transfer, and protein synthesisA. Assembly of nucleotide substrates PsicofuranineB. Replication of genetic information Mitomycins, Porfiromycin, Nalidixic Acid and GriseofulvinC. Transcription of genetic information Actinomycin DD. Translation of genetic information1. Amino acid activation2. The ribosomea. mRNA binding Chloramphenicolb. tRNA binding Tetracyclinesc. mRNA translation Streptomycin, Kanamycin and Neomycin3. Peptide synthesis Puromycin4. Locus Unclear Erythromycin, LincomycinIV. Antibiotics that influence the function or biosynthesis of the...References1. GALE EF: Mechanisms of antibiotic action. Pharmacol. Rev. 15: 481, 1963. MedlineGoogle Scholar2. FEINGOLD DS: Antimicrobial chemotherapeutic agents: The nature of their action and selective toxicity. New Eng. J. Med. 269: 900, 957, 1963. CrossrefMedlineGoogle Scholar3. BURCHALLFERONEHITCHINGS JJRGH: Antibacterial chemotherapy. Ann. Rev. Pharmacol. 5: 53, 1965. CrossrefMedlineGoogle Scholar4. GERHART JC: Subunits for control and catalysis in aspartate transcarbamylase. Brookhaven Sympos. Biol. 17: 222, 1964. MedlineGoogle Scholar5. CAIRNS J: The bacterial chromosome and its manner of replication as seen by autoradiography. J. Molec. Biol. 6: 208, 1963. CrossrefMedlineGoogle Scholar6. 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SMITHDAVIS DHBD: Inhibition of nucleic acid synthesis by novobiocin. Biochem. Biophys. Res. Commun. 18: 796. 1965. CrossrefGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Durham, North CarolinaFrom the Departments of Medicine and Biochemistry, Duke University Medical Center, Durham, N. C.Dr. Carter, Fellow in Medicine, was supported by training grant 5T1-GM516-05 from the U. S. Public Health Service, Washington, D. C.Dr. McCarty is an Associate Professor of Biochemistry. His research is supported in part by grants GM-12805-01 and ACS-ACP 363 from the U. S. Public Health Service, Washington, D. C.Requests for reprints should be addressed to Kenneth S. McCarty, Ph.D., Department of Biochemistry, Duke University, Durham, N. C.*Antibiotics in bold face are currently in clinical use. 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PETTY, M.D.Mechanisms of Action of Antimicrobial AgentsThe Cephalosporin AntibioticsThe TetracyclinesPrevention of 5-FU Induced NADPH-D Translocation in Colonic Epithelium by Antibiotics and the Effect on the Intestinal Bacterial FloraAddendaAddenda 1 May 1966Volume 64, Issue 5Page: 1087-1113KeywordsAntibioticsBiochemistryBlood plasmaMedical servicesMolecular biologyProtein synthesisRespirationRibosomesTetracyclinesTransfer RNA ePublished: 1 December 2008 Issue Published: 1 May 1966 PDF downloadLoading ...