tbuckley/cabot-search huggingface dataset:
High-resolution crystal structure and IgE recognition of the major grass pollen allergen Phl p 3
Authors: S. C. Devanaboyina, C. Cornelius, C. Lupinek, K. Fauland, F. Dall'Antonia, A. Nandy, S. Hagen, S. Flicker, R. Valenta, W. Keller
Journal: Allergy (2014)

Background Group 2 and 3 grass pollen allergens are major allergens with high allergenic activity and exhibit structural similarity with the C-terminal portion of major group 1 allergens. In this study, we aimed to determine the crystal structure of timothy grass pollen allergen, Phl p 3, and to study its IgE recognition and cross-reactivity with group 2 and group 1 allergens. Methods The three-dimensional structure of Phl p 3 was solved by X-ray crystallography and compared with the structures of group 1 and 2 grass pollen allergens. Cross-reactivity was studied using a human monoclonal antibody which inhibits allergic patients' IgE binding and by IgE inhibition experiments with patients' sera. Conformational Phl p 3 IgE epitopes were predicted with the algorithm SPADE, and Phl p 3 variants containing single point mutations in the predicted IgE binding sites were produced to analyze allergic patients' IgE binding. Results Phl p 3 is a globular β-sandwich protein showing structural similarity to Phl p 2 and the Phl p 1–C-terminal domain. Phl p 3 showed IgE cross-reactivity with group 2 allergens but not with group 1 allergens. SPADE identified two conformational IgE epitope-containing areas, of which one overlaps with the epitope defined by the monoclonal antibody. The mutation of arginine 68 to alanine completely abolished binding of the blocking antibody. This mutation and a mutation of D13 in the predicted second IgE epitope area also reduced allergic patients' IgE binding. Conclusion Group 3 and group 2 grass pollen allergens are cross-reactive allergens containing conformational IgE epitopes. They lack relevant IgE cross-reactivity with group 1 allergens and therefore need to be included in diagnostic tests and allergen-specific treatments in addition to group 1 allergens.
New Etiology for Intestinal Uptake of Thallium-201
Authors: MICHAEL MORRISON, SHONA FAIRHOLM, MICHAEL R. FREEMAN
Journal: Clinical Nuclear Medicine (1989)

A patient with both rest and exercise thallium images for unstable angina demonstrated marked large intestinal uptake of thallium. However, the thallium uptake in the large intestine was noted only after exercise. The only change in the patient status between the two studies was the administration of verapamil. Thus, verapamil administration has been demonstrated to be a new cause for gut uptake of thallium.
Immunohistochemical detection for nuclear beta-catenin in sporadic basal cell carcinoma.
Authors: F. Yamazaki, Y. Aragane, A. Kawada, T. Tezuka
Journal: British Journal of Dermatology (2001)

Background Despite the increasing incidence of basal cell carcinoma (BCC), its pathogenesis has remained largely unknown. Recently, it was reported that genes involved in tissue morphogenesis, such as sonic hedgehog or patched, were found to be mutated in BCC, suggesting the involvement of those molecules in the pathogenesis of this tumour. Furthermore, there is evidence that the Wnt-mediated signalling pathway may be one of the downstream targets of sonic hedgehog-mediated signalling, which has led us to focus on molecular events on the Wnt pathway in BCC. Among the signal transducers involved in the Wnt pathway, it is clear that β-catenin plays a pivotal role in the promotion of morphogenesis and cell growth. In respect to this, it has been reported that, in particular circumstances, as in colorectal cancers, β-catenin migrates to the nuclei, where it exerts an ability to activate the transcription of various genes. Objectives To investigate the cellular distribution of β-catenin in skin tumours, in particular, in BCC. Methods Twenty skin biopsy specimens derived from BCC, 10 from inflammatory skin diseases and five from squamous cell carcinomas were immunostained with an antibody directed against β-catenin. Results Fourteen of the 20 BCC samples tested showed nuclear localization of β-catenin, while none of the other samples gave rise to positive nuclear staining. Conclusions Nuclear localization of β-catenin is a characteristic feature of BCC; this suggests its tumorigenic role in this tumour. This gives us a further insight into the molecular pathogenesis of BCC.
Obesity and lower teenage pregnancy rates
Authors: A.-T. McGill
Journal: BMJ (2014)

It seems heartening that unplanned conception and pregnancy rates in teenagers are decreasing in England,1 New Zealand,2 and the United States.3 However, we should be cautious in thinking that our social programmes and availability of new family planning technologies are the only solutions to this problem.

The authors of the above papers mentioned that many resources and services have …
Cetuximab Pharmacokinetics in End-Stage Kidney Disease Under Hemodialysis
Authors: Juliette Thariat, Nicolas Azzopardi, Frederic Peyrade, Vincent Launay-Vacher, José Santini, Thierry Lecomte, Marie-Christine Etienne-Grimaldi, Gilles Paintaud, Gerard Milano
Journal: Journal of Clinical Oncology (2008)
Professional Organizations' Position Statements on Physician-Assisted Suicide: A Case for Studied Neutrality
Authors: Timothy E. Quill, Christine K. Cassel
Journal: Annals of Internal Medicine (2003)

Position statements opposing legalization of physician-assisted suicide by organizations such as the American College of Physicians-American Society of Internal Medicine rightly emphasize that palliative care should be the standard of care for the dying, and that the inadequacies that exist in its delivery should be remedied. But such position statements generally understate the limitations of palliative care to alleviate some end-of-life suffering, and they do not provide adequate guidance about how physicians should approach patients with intractable suffering who are prepared to die. In this manuscript, we briefly present data about severe suffering before death for terminally ill patients, including those enrolled in hospice programs. We also review some of what is known about requests and responses for physician-assisted suicide in Oregon and in the rest of the United States. Preliminary data from Oregon suggest that legally sanctioned access to physician-assisted suicide is used by a very small number of patients and seems to be associated with improved delivery of hospice and palliative care. Physicians of good will, deep religious convictions, and considerable palliative care experience exist on both sides of the debate about legalization of physician-assisted suicide. In an effort to respect this diversity, and to encourage our profession to continue to struggle with the genuine dilemmas faced by some patients toward the end of their lives and by their families, we argue in favor of medical organizations' taking a position of studied neutrality on this contentious issue.
Monitoring Considerations for Port-Access Cardiac Surgery
Authors: Lawrence C. Siegel, Frederick G. St. Goar, John H. Stevens, Mario F. Pompili, Thomas A. Burdon, Bruce A. Reitz, William S. Peters
Journal: Circulation (1997)

Background A method for monitoring patients was evaluated in a clinical trial of minimally invasive port-access cardiac surgery with closed chest endovascular cardiopulmonary bypass. Methods and Results Cardiopulmonary bypass was conducted in 25 patients through femoral cannulas. An endovascular pulmonary artery vent was placed in the main pulmonary artery through a jugular vein. For mitral valve surgery, a catheter was placed in the coronary sinus for delivery of cardioplegia. A balloon catheter (“endoaortic clamp,” EAC) used for occlusion of the ascending aorta, delivery of cardioplegia, aortic root venting, and pressure measurement was inserted through a femoral artery and initially positioned by use of fluoroscopy and transesophageal echocardiography (TEE). Potential migration of the EAC was monitored by (1) TEE of the ascending aorta, (2) pulsed-wave Doppler of the right carotid artery, (3) balloon pressure, (4) comparison of aortic root pressure and right radial artery pressure, and (5) fluoroscopy. TEE, fluoroscopy, and pressure measurement were effective in monitoring catheter insertion and position. With inadequate balloon inflation, migration of the EAC toward the aortic valve could be detected with TEE. During administration of cardioplegia, TEE showed movement of the balloon away from the aortic valve, and migration into the aortic arch was detectable with loss of carotid Doppler flow. Stability of EAC position was demonstrated with appropriate balloon volume. Cardioplegic solution was visualized in the aortic root, and aortic root pressure changed appropriately during administration of cardioplegia. Venous cannula position was optimized with TEE and endopulmonary vent flow measurement. Conclusions An effective method has been developed for monitoring patients and the catheter system during port-access cardiac surgery.
The Harveian Oration ON FORERUNNERS OF HARVEY IN ANTIQUITY: Delivered before the Royal College of Physicians of London on St. Luke's Day (October 18th)
Authors: R. Crawfurd
Journal: BMJ (1919)

WHEN, Sir, you entrusted to me the lh0nourable duty of delivering this annual addros, it seemed idle to suppose that I could add to tle.central theme, whlielh has inspired this occasion now for more thau 250 years, anything that had not been said by one or other of tlle long line of umy predecessors in the post.But wlhen I came to examinie soene of the outstanding accounts of the hiistory of thle discovery Df tlle circulation I could iiot but feel t4hat the fLuller knowledge we niow possess of thse writings of the men of science of ancient days demanded a readjustment of traditional beliefs: we lhave claimed too much for tlhe ardent anatomists of the Renaissance; we lhave coneded too little to the master mlinds of antiquity; in particular, I venture to thiink that the cla,ims of Aristotle have naot received their due meed of recognition.It will be consonant to the directions of Harvey's testa- m.ent that I slhould testify to-day how great a part of our present-day knowledge of the scientific works of Aristotlo is due to a late Fellow of tlhfs College, and that I should commemorate him by name.I refer, of, course, to tle late Dr. William Ogle.His translation of :the treatise, " On the Parts of Animals," witlh commentary and copious anno- tation, was -first publislhed in 1x82, and rewritten witlh diligent revision in 1911,, when tlhe.. hand of deatlh was lhard upon lhim.I had the privilege of disoussing withi him many points of his work, and.I desire therefoio that lie, being dead, may yet speak tp you tlhrough the medium- of my lips.In 1897 this first essay was followed, by a second dealing in similar manner -with t-he con-joint treatises on Yoqth and Old Age, Lif4 and Deatlh, ad on Respiration.Every page of these volumes is instinct with refined scholarship linked to a wide knowledge of -biology.If there be any herq who weditate a like venture iinto the by-ways of ancient scienc%, I cannot do better than adopt -tue words of thle, great man we.commermorate to-day, and exhort them to imitate this benefactor,-and contribute their endeavours for ft}he advanuement of, this, society according to the example of this deceased, benefactor.Trhese volumues will survive as memorials of an age of British mnedicine in whiclh Science and Literature walked hand in hand, side by side with' a few more, of Whaich it is meet that on this occasion I. sh,uld -name those monu- mental volumes in wlichl you, Mr. President, have en- shrined the life-history of that great seat of medical learning which bears the name. of Harvey on its roll of honour.
1099 ITPA VARIANTS PREDICT TREATMENT-INDUCED ANEMIA AND THE NEED FOR RIBAVIRIN DOSE REDUCTION AND ERYTHROPOIETIN SUPPORT
Authors: P.J. Clark, A. Aghemo, E. Degasperi, E. Galmozzi, A.J. Thompson, K. Patel, M. Grazia Rumi, G.M. Prati, A.J. Muir, M. Colombo
Journal: Journal of Hepatology (2012)
Occurrence of rheumatoid arthritis is not increased in the first degree relatives of a population based inception cohort of inflammatory polyarthritis.
Authors: M A Jones, A J Silman, S Whiting, E M Barrett, D P Symmons
Journal: Annals of the Rheumatic Diseases (1996)

OBJECTIVE: To determine the risk of rheumatoid arthritis (RA) in first degree relatives of a true population based sample of probands with inflammatory polyarthritis. METHODS: In a case-control study, a two stage screening procedure was used to ascertain the prevalence of RA in 518 first degree relatives of 207 Norfolk Arthritis Register cases registered in 1990 and 414 first degree relatives of 180 local controls. An initial joint symptom and medical history questionnaire was followed by a physical examination, and serological and radiological evaluation of those with symptoms. RESULTS: The prevalence of RA in the first degree relatives of all the Norfolk Arthritis Register cases was 7.7/1000, compared with 4.8/1000 in the first degree relatives of the controls, with a risk ratio of 1.6 (95% confidence interval 0.3 to 8.7). This very modest increase was also seen when the analysis was restricted to the first degree relatives of Norfolk Arthritis Register cases who satisfied the American Rheumatism Association criteria for RA: prevalence rate 7.2/1000. CONCLUSION: There was no evidence of an important increased familial risk of RA in this community based sample. These data are compatible with others from immunogenetic studies showing only weak HLA associations with community ascertained RA.
Providing High-Value, Cost-Conscious Care
Authors: Erik A. Wallace
Journal: Annals of Internal Medicine (2011)

Letters20 December 2011Providing High-Value, Cost-Conscious CareErik A. Wallace, MDErik A. Wallace, MDFrom University of Oklahoma, Tulsa, Tulsa, OK 74012.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-155-12-201112200-00018 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:Nine years ago, during my third postgraduate year as an internal medicine resident, my attending physician asked me why I had ordered a test. Unsatisfied with my answer, he followed with the question, “Do you know how much that test costs?” I did not know. He then stated, “Well, then you should pay for it.”At the time I did not know I was being evaluated on the competency of “cost-conscious care and stewardship of resources” recently proposed by Weinberger (1). However, the lesson I learned that day about cost-conscious care—and the mere $100 test—left an indelible ...References1. Weinberger SE. Providing high-value, cost-conscious care: a critical seventh general competency for physicians. Ann Intern Med. 2011;155:386-8. [PMID: 21930856] LinkGoogle Scholar2. American Association of Medical Colleges. U.S. Medical School First-Year Enrollment, 2000-2010. Accessed at www.aamc.org/download/152934/data/enrollment_data_2010.pdf on 21 September 2011. Google Scholar3. Doran KM, Kirley K, Barnosky AR, Williams JC, Cheng JE. Developing a novel poverty in healthcare curriculum for medical students at the University of Michigan Medical School. Acad Med. 2008;83:5-13. [PMID: 18162743] CrossrefMedlineGoogle Scholar Author, Article, and Disclosure InformationAuthors: Erik A. Wallace, MDAffiliations: From University of Oklahoma, Tulsa, Tulsa, OK 74012.Disclosures: None disclosed. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoProviding High-Value, Cost-Conscious Care: A Critical Seventh General Competency for Physicians Steven E. Weinberger Providing High-Value, Cost-Conscious Care Steven E. Weinberger Providing High-Value, Cost-Conscious Care Brian Pollak Providing High-Value, Cost-Conscious Care Jeremy D. Graham , Darryl K. Potyk , and Elise D. Raimi Providing High-Value, Cost-Conscious Care Christine K. Cassel Providing High-Value, Cost-Conscious Care Carlos O. Weiss , Maia Holden , and Matthew McNabney Providing High-Value, Cost-Conscious Care Ira S. Nash Providing High-Value, Cost-Conscious Care Christopher L. Knight Metrics 20 December 2011Volume 155, Issue 12Page: 859-860KeywordsConflicts of interestForecastingHealth carePatientsResidencySexual identity ePublished: 20 December 2011 Issue Published: 20 December 2011 Copyright & PermissionsCopyright © 2011 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Propranolol in angina pectoris. Comparison of long-acting and standard-formulation propranolol.
Authors: J O Parker, A Porter, J D Parker
Journal: Circulation (1982)

In a double-blind, crossover study in 20 patients with stable angina pectoris, the effects of long-acting propranolol, 160 mg administered once daily for 4 weeks, were compared with those of standard propranolol, 40 mg given four times daily for 4 weeks. The patients suffered no adverse effects when they were switched between treatment schedules. The average number of episodes of angina during the 4 weeks on long-acting propranolol was 7.3 and on standard propranolol. 6.3. Average nitroglycerin consumption was 5.8 and 4.9 tablets during therapy with these two drug programs. The resting values for heart rate, systolic blood pressure and rate-pressure product were similar when determined 25.4 hours after a dose of long-acting propranolol and 10.7 hours after standard propranolol. When the patients exercised at these times, patients on long-acting propranolol and standard propranolol had similar walking times to the onset of angina and to the development of moderate angina. The values for heart rate, systolic blood pressure and rate-pressure product were similar at rest and during exercise during these two treatment programs. We conclude that long-acting propranolol administered in a dose of 160 mg daily is as effective as 50 mg of standard propranolol four times daily.
A CHANGE IN RABBIT FIBROMA VIRUS SUGGESTING MUTATION
Authors: C. H. Andrewes
Journal: The Journal of Experimental Medicine (1936)

A strain of rabbit fibroma is described causing in inoculated animals acute inflammatory lesions very different from the fibroma-like growths induced by the original strain. The new inflammatory strain cross-immunised with the normal strain but not with various other viruses. Efforts at changing one strain into the other were unsuccessful. Another, referred to as the changed, strain produced lesions of mixed character, partly inflammatory, partly fibromatous; it continued to behave in this way through numerous passages. An artificial mixture of inflammatory and fibromatous viruses behaved in all respects like the changed strain. Discussion of the significance of the findings is reserved for a separate paper (3) where the facts can be considered in relation to those described by Shope (2).
An Army Medical School in London
Authors: G. H. Makins
Journal: BMJ (1901)

want of plhosphatic salts in the organism.He combineed with this treatment a diet which was ricl in plhosphates.Professor Kraske (Freiburg), who followed Kochelr, said his experience was limited to 425 cases, and lie had had a deatlhrate of 5 per cent.Dr. Goldmann related a case of intrathoracic goitre which proved to be formed of masses of carcinomatous tissue uindergoing tuberculous degeneration.Dr. Riedel suggested that the presence of the neighbouring organs forced the left side of the enlarged gland downwards into the thorax, while the riglht side was displaced upwards toward the lobe of the ear.In operating, he believed that it was advisable to tie the veins first, before the extirpation was undertaken.Herr K65nig said that goitres were observed in flat as well as mountainous districts; and it was a curious fact that, out of 8o cases which he had:seen in Berlin, about one-half occurred in natives of the city.
Racial Differences in the Association Between Sex Hormone–Binding Globulin and Adiposity in Premenopausal Women
Authors: Edwina H. Yeung, Cuilin Zhang, Mary L. Hediger, Jean Wactawski-Wende, Enrique F. Schisterman
Journal: Diabetes Care (2010)

OBJECTIVE To assess the associations between measures of adiposity and sex hormone– binding globulin (SHBG) and to evaluate whether such associations differ by race. RESEARCH DESIGN AND METHODS Adiposity was measured by anthropometry and dual-energy X-ray absorptiometry among women (146 white, 50 black, and 25 Asian) aged 18–44 years in the BioCycle study. SHBG was repeatedly measured over one to two menstrual cycles. The ratio of trunkal to leg fat (T/L) was used to assess upper to lower body adiposity. RESULTS Among whites, all adiposity measures were significantly and inversely associated with SHBG. Among blacks, BMI (β = −0.032), waist circumference (β = −0.016), and T/L (β = −0.033) were significantly associated with SHBG, whereas total and trunkal fat were not (P interaction with race &amp;lt;0.04). Among Asians, measures of central and upper body fat were significantly associated with SHBG (e.g., T/L, β = −0.84) but not BMI. CONCLUSIONS Associations between SHBG and adiposity differ by race among premenopausal women.
Observations on Suicidal Behavior Among American Indians
Authors: H. L. P. RESNIK, LARRY H. DIZMANG
Journal: American Journal of Psychiatry (1971)

The authors discuss the sociocultural factors that have produced suicide rates on some Indian reservations that are significantly higher than the national average. Among the most important of these factors are the breakdown of traditional values and patterns of behavior resulting from enforced residence on reservations, geographical isolation, widespread unemployment, and a high incidence of alcoholism.
Impaired Water Handling in Chronic Airways Disease
Authors: R. J. White, D. F. Woodings
Journal: BMJ (1971)

The response to a standard water load (20 ml/kg body weight) was studied in 20 patients with chronic obstructive airways disease and in 13 healthy subjects. The percentage of the water load excreted in four hours was significantly lower in the patients (mean 51%) than in the controls (mean 106%). The maximum urine flow, osmolar clearance, free water clearance, and creatinine clearance were also significantly reduced in the patients. There was a significant inverse correlation between the percentage of load passed and the arterial PCO(2) (r = -0.798). Among the several possible causes of the reduced excretion of water which are discussed is a direct effect of hypercapnia.
NEW LIVER-GRASPING FORCEPS
Authors: Emanuel Friend
Journal: JAMA (1925)

Most surgeons who have had much experience in operative work in the right upper quadrant of the abdomen fully realize the difficulty one finds in visualizing the bile tracts, unless proper traction is made on the liver, especially in high lying livers. With this idea in mind, I have devised an instrument 9½ inches (24.15 cm.) in length, with fenestrated oval grasping jaws 4.5 by 3 cm. in diameter, open on one end to permit soft rubber tubing to be slipped over the entire grasping portion, which may be renewed whenever it is desirable. A long ratchet catch is provided, permitting of soft bodies (livers), large or small, being grasped and the forceps locked, without undue pressure on account of forcing the instrument to be locked. In my hands this instrument has proved of inestimable value in surgery of the bile tract. With it, the liver can be grasped and