tbuckley/cabot-search huggingface dataset:
The illness and death of Eva Perón: cancer, politics, and secrecy
Authors: Barron H Lerner
Journal: The Lancet (2000)

When Eva (Evita) Perón underwent a hysterectomy for cervical cancer in November, 1951, she believed the surgeon would be the Argentine physician Ricardo Finochietto. But, unbeknown to her, an American, New York cancer surgeon George T Pack, actually performed the operation. Pack, entering the operating room after she was sedated and leaving before she awoke, never met Evita.
Multiple loci associated with indices of renal function and chronic kidney disease
Authors: Anna Köttgen, Nicole L Glazer, Abbas Dehghan, Shih-Jen Hwang, Ronit Katz, Man Li, Qiong Yang, Vilmundur Gudnason, Lenore J Launer, Tamara B Harris, Albert V Smith, Dan E Arking, Brad C Astor, Eric Boerwinkle, Georg B Ehret, Ingo Ruczinski, Robert B Scharpf, Yii-Der Ida Chen, Ian H de Boer, Talin Haritunians, Thomas Lumley, Mark Sarnak, David Siscovick, Emelia J Benjamin, Daniel Levy, Ashish Upadhyay, Yurii S Aulchenko, Albert Hofman, Fernando Rivadeneira, André G Uitterlinden, Cornelia M van Duijn, Daniel I Chasman, Guillaume Paré, Paul M Ridker, W H Linda Kao, Jacqueline C Witteman, Josef Coresh, Michael G Shlipak, Caroline S Fox
Journal: Nature Genetics (2009)
Navigational error in the heart leads to premature ventricular excitation
Authors: Hiroshi Akazawa, Issei Komuro
Journal: Journal of Clinical Investigation (2011)

In the normal heart, an insulating barrier separates the atria and ventricles. The only way in which electrical impulses can cross this barrier is via the atrioventricular (AV) node, which delays impulse conduction to ensure the forward flow of the blood. However, in some individuals, additional muscular bundles (accessory pathways) allow rapid conduction of electrical impulses from the atria to the ventricles, resulting in premature ventricular excitation and contraction. In this issue of the JCI, two independent research groups demonstrate that erroneous development of the embryonic AV canal, which performs a similar function to that of the adult AV node, is a novel mechanism by which accessory pathways can form.
Broadly neutralizing antibodies protect against hepatitis C virus quasispecies challenge
Authors: Mansun Law, Toshiaki Maruyama, Jamie Lewis, Erick Giang, Alexander W Tarr, Zania Stamataki, Pablo Gastaminza, Francis V Chisari, Ian M Jones, Robert I Fox, Jonathan K Ball, Jane A McKeating, Norman M Kneteman, Dennis R Burton
Journal: Nature Medicine (2007)
Duplication of FGF3, FGF4, FGF19 and ORAOV1 causes hair ridge and predisposition to dermoid sinus in Ridgeback dogs
Authors: Nicolette H C Salmon Hillbertz, Magnus Isaksson, Elinor K Karlsson, Eva Hellmén, Gerli Rosengren Pielberg, Peter Savolainen, Claire M Wade, Henrik von Euler, Ulla Gustafson, Åke Hedhammar, Mats Nilsson, Kerstin Lindblad-Toh, Leif Andersson, Göran Andersson
Journal: Nature Genetics (2007)
Randomized trial of leuprorelin and flutamide in male patients with hepatocellular carcinoma treated with tamoxifen
Authors: Jean–Claude Trinchet
Journal: Hepatology (2004)

The growth of hepatocellular carcinoma (HCC) is thought to be dependent on androgens, as androgen receptors are present in most of these tumors. The aim of this multicenter trial was to assess the effect of antiandrogens in patients who have advanced HCC. Male patients with advanced HCC were randomized into 2 groups treated with (1) leuprorelin (3.75 mg/mo subcutaneously), flutamide (750 mg/d orally), and tamoxifen (30 mg/d orally) or (2) tamoxifen alone (30 mg/d orally) administered until death. Survival was the main end point (log–rank test). The required sample size was 375 patients (alpha, 5%; beta, 10%; 1–year survival, 45% in treated group and 30% in controls). Between February 1994 and January 1998, 376 male patients (mean age, 66 years; treated group, n = 192; control group, n = 184) were included. No baseline imbalance was found between the groups. At the reference date (January 1, 2003), 183 deaths (95.3%) were observed in the treated group and 177 deaths (96.2%) were observed in controls. Thirteen patients were lost to follow–up. Median survival time was estimated to be 135.5 days (95% CI, 112–189) and 176 days (95% CI, 141–227) in treated and control groups, respectively ( P = .21). Crude and adjusted relative risks of death in the treated group were estimated at 1.14 (95% CI, 0.93–1.40) and 1.08 (95% CI, 0.87–1.33; P = .48) respectively. Premature interruption of treatment was more frequent in the treated group (n = 45) than in controls (n = 22; P = .0045), mainly because of digestive side effects. In conclusion , no benefit in survival was found with antiandrogenic treatment in male patients with advanced HCC. (Hepatology 2004;40:1361-1369.)
Experience with 200 Renal Artery Reconstructive Procedures for Hypertension or Renal Failure
Authors: GEORGE C. MORRIS, MICHAEL E. DEBAKEY, DENTON A. COOLEY, E. STANLEY CRAWFORD
Journal: Circulation (1963)

Renovascular hypertension is the most common form of reversible hypertension. An analysis of 200 renal artery reconstructive procedures identified atherosclerosis as the arteriopathic lesion in 83 per cent of cases and fibromuscular hyperplasia in 13 per cent of cases. Bilateral renovascular disease was found in 31 per cent of cases. Renal arteriography is the most significant factor in the diagnostic evaluation of the hypertensive subject. Bypass graft and patch-graft angioplasty were the most commonly employed principles of renal artery reconstruction in this series. The occlusive process in the renal artery produced a pressure gradient exceeding 25 mm. Hg in 76 per cent of cases. The average period of observation following operation in these 200 patients was 1.6 years, ranging between 3 months and 5 years. Eighty per cent of patients are now normotensive. The primary goal of operation in 12 patients was reversal of renal failure due to severe bilateral renal artery occlusive disease. Disappearance of azotemia with improved renal function followed revascularization in 11 of 12 patients.
Thrombectomy with distal protection prior to stenting is a novel strategy to obtain optimal reperfusion in patients with acute myocardial infarction
Authors: Naoki Ito, Masato Nakamura, Hirotaka Komatsu, Hiroya Nuruki, Suguru Yajima, Rintaro Nakajima, Masato Yamamoto, Takuro Takagi, Hisao Hara, Hironori Hirai, Tetsu Yamaguchi, Ohashi Hospital
Journal: Journal of the American College of Cardiology (2003)
Total, LDL, and HDL Cholesterol Decrease With Age in Older Men and Women
Authors: Assiamira Ferrara, Elizabeth Barrett-Connor, Jun Shan
Journal: Circulation (1997)

The purpose of the present study was to study the effects of age, weight change, and covariates on lipid and lipoprotein levels cross-sectionally and prospectively in an elderly population.A community-based sample of 1041 men and 1303 women aged 50 to 93 years was studied cross-sectionally in 1984 to 1987, with follow-up of 372 men and 545 women 8 years later. In the cross-sectional study, levels of total cholesterol (TC) and LDL cholesterol (LDL-C) decreased and levels of HDL cholesterol (HDLC) increased with age in men (all P < .001) but not in women. In the prospective study, TC, LDL-C, and HDL-C levels all decreased in both men and women, in all age groups (50 to 64 years, 65 to 74 years, and > or = 75 years) and in all weight change groups (> 2.5-kg loss, change within 2.5 kg, and > 2.5-kg gain) and in all waist girth change groups, for an overall decrement of approximately 1% per year. In multiple linear regression models, change in weight was the most important independent and consistent predictor of changes in TC, LDL-C, and HDL-C. Similar results were obtained in analyses excluding subjects taking lipid-lowering drugs or estrogen and in analyses adjusted for changes in cigarette smoking, alcohol intake, physical activity, medication use, and incident myocardial infarction, cancer, or diabetes.Cross-sectional decrements in TC and LDL-C with age in men are not explained by survivor bias because they are also observed prospectively. Although weight change was the most important explanatory variable, TC, LDL-C, and HDL-C levels also decreased in those who lost or gained weight. Age was not an independent predictor of change. Other prospective studies are recommended to better define the causes and consequences of cholesterol and lipoprotein changes in old age.
TOTAL LOSS OF PIGMENT IN A NEGRO (ACQUIRED FORM)
Authors: Elmore B. Tauber
Journal: JAMA (1933)

Achromoderma in the Negro may be classified in two forms, the congenital and the acquired. Reports of cases of the congenital type are numerous. Musser, in 1924, traced a family tree of three generations of Negroes and showed recessive characteristics in albinos. The literature since then has been voluminous but has no bearing on our particular case. The second, or acquired, form of achromoderma is extremely rare. Only one other case has been reported up to this time. This report was published in 1931, by Dr. Lewis A. Golden<sup>1</sup>of Boston. A résumé of this Negro's condition appeared in the<i>Boston Medical and Surgical Review</i>on July 26, 1917, the case having been shown by the late Dr. Thorndyke. Apparently, our case is the second of its kind. <h3>REPORT OF CASE</h3> J. W., a Negro, aged 32, had a rash seventeen years ago, which covered the entire body. He
Candlelighters Enter Third Decade By Tackling New Issues
Authors: John Burklow
Journal: JNCI Journal of the National Cancer Institute (1990)

Journal Article Candlelighters Enter Third Decade By Tackling New Issues Get access John Burklow John Burklow Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 82, Issue 20, 17 October 1990, Pages 1612–1613, https://doi.org/10.1093/jnci/82.20.1612 Published: 17 October 1990
Aminoacridine Uptake by Experimental Tumors
Authors: Norman B. Ackerman
Journal: JAMA (1965)

Previous studies with certain aminoacridine compounds revealed that a selective uptake of these compounds occurred in tumors transplanted to the lungs of rats.<sup>1</sup>The compounds were identified in the lung tumors by examination under ultraviolet light. As early as ten minutes after administration, the aminoacridines were more apparent in the tumors than in the surrounding lung tissue, and by 24 hours, only the tumors fluoresced under the ultraviolet light. Tumor fluorescence was weak but still present at seven days. Studies were also performed with an aminoacridine tagged with radioactive iodine (<sup>131</sup>I). Radioautographs of lung tumors in animals given this compound demonstrated the selective uptake by the tumors, and counting weighed samples of tumor and normal lung in a well-scintillation counter revealed that the tumor contained five times more activity than did the normal lung. Aminoacridines are three ringed hydrocarbons (Fig 1) and include various antimalarial, antiparasitic, and antibacterial
The safety of acupuncture
Authors: C. Vincent
Journal: BMJ (2001)

Papers pp 485, 486 

For many patients attracted to complementary medicine its safety has been one of its principal appeals. Complementary methods, including acupuncture, are seen as less invasive, more natural, and less liable to adverse effects than more orthodox forms of treatment. Critics of complementary medicine have, however, often castigated it as being dangerous, sometimes in the same breath as ridiculing complementary methods for their lack of effectiveness and scientific support. For many years, certainly until the mid-1980s, these debates were little more than exchanges of usually entrenched and unwavering opinion on either side.1 Now we begin to have some evidence.

The early literature on the safety of acupuncture consisted entirely of case reports. Rampes and James summarised all case reports between 1966 and 1993, finding 395 instances of complications.2 Many were minor, such as bruising or fainting, but 216 were serious, including several cases of pneumothorax and injury to the spinal cord. Only one death due to acupuncture was reported, in which a needle penetrated the pericardium. As the acupuncture was self administered, however, this perhaps falls …
Corneomandibular Reflex (Wartenberg Reflex) in Coma
Authors: Ioannis Heliopoulos, Konstantinos Vadikolias, Georgios Tsivgoulis, Dimitrios Mikroulis, Soultana Tsakaldimi, Charitomeni Piperidou
Journal: JAMA Neurology (2013)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Neurology HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Neurology journal
Postnatal expression in hyaline cartilage of constitutively active human collagenase-3 (MMP-13) induces osteoarthritis in mice
Authors: Lisa A. Neuhold, Loran Killar, Weiguang Zhao, Mei-Li A. Sung, Linda Warner, John Kulik, James Turner, William Wu, C. Billinghurst, T. Meijers, A. Robin Poole, Philip Babij, Louis J. DeGennaro
Journal: Journal of Clinical Investigation (2001)

It has been suggested that increased collagenase-3 (MMP-13) activity plays a pivotal role in the pathogenesis of osteoarthritis (OA). We have used tetracycline-regulated transcription in conjunction with a cartilage-specific promoter to target a constitutively active human MMP-13 to the hyaline cartilages and joints of transgenic mice. Postnatal expression of this transgene resulted in pathological changes in articular cartilage of the mouse joints similar to those observed in human OA. These included characteristic erosion of the articular cartilage associated with loss of proteoglycan and excessive cleavage of type II collagen by collagenase, as well as synovial hyperplasia. These results demonstrate that excessive MMP-13 activity can result in articular cartilage degradation and joint pathology of the kind observed in OA, suggesting that excessive activity of this proteinase can lead to this disease.
Personalizing Breast Cancer Staging by the Inclusion of ER, PR, and HER2
Authors: Sanjay P. Bagaria, Partha S. Ray, Myung-Shin Sim, Xing Ye, Jaime M. Shamonki, Xiaojiang Cui, Armando E. Giuliano
Journal: JAMA Surgery (2013)

<h3>Importance</h3> Nonanatomic factors, such as histologic grade and biomarkers, can guide breast cancer management but are not included in the current TNM staging system. <h3>Objective</h3> To use as an example the triple-negative phenotype (TNP) defined by the absence of estrogen receptor (ER), progesterone receptor (PR), and human epidermal growth factor 2 (HER2) to examine whether such inclusion improves the prognostic accuracy of TNM staging for breast cancer. <h3>Design, Setting, and Participants</h3> Women diagnosed with primary invasive ductal breast cancer from January 1, 1991, through December 31, 2008, were identified from a prospective institutional database. Excluded were patients who received neoadjuvant therapy, those whose staging information was incomplete, or those whose tumor lacked ER, PR, and HER2 data. Breast cancers were categorized by TNM stage and by the presence or absence of TNP. <h3>Main Outcomes and Measures</h3> Overall survival at 5 years. <h3>Results</h3> Database review identified 1842 consecutive eligible patients with breast cancer. When patients were stratified by TNM stage, overall survival curves for those with TNP breast cancer matched those for patients whose non-TNP breast cancer was 1 TNM stage higher. Multivariable analysis showed that TNP status was a powerful prognostic variable, and the likelihood ratio test revealed that the prognostic accuracy of the TNM staging system that incorporated TNP was superior to the current TNM staging system (<i>P</i> &lt; .001). A TNM staging system that incorporated TNP reduced early-stage compression by 15%. <h3>Conclusions and Relevance</h3> The internationally recognized and easily reproducible examination of ER, PR, and HER2 status exemplifies how nonanatomic factors can improve the prognostic accuracy of breast cancer staging.
Familial and Sporadic Renal Oncocytomas &amp;ndash; A Comparative Molecular&amp;ndash;Genetic Analysis
Authors: Kerstin Junker, Gregor Weirich, Petr Moravek, Miroslaw Podhola, Bianka Ilse, Arndt Hartmann, Joerg Schubert
Journal: European Urology (2001)
Effects of ozone exposure on lipid metabolism in human alveolar macrophages.
Authors: M Friedman, M C Madden, J M Samet, H S Koren
Journal: Environmental Health Perspectives (1992)

Alveolar macrophages (AM) store arachidonic acid (AA), which is esterified in cellular phospholipids until liberated by phospholipase A2 or C after exposure to inflammatory stimuli. After release, there can be subsequent metabolism of AA into various potent, biologically active mediators including prostaglandins and platelet-activating factor (PAF). To examine the possibility that these mediators may account for some of the pathophysiologic alterations seen in the lung after ozone (O3) exposure, human AM were collected by bronchoalveolar lavage of normal subjects, plated into tissue culture dishes, and the adherent cells were incubated with [3H]AA or [3H]lysoPAF. Human AM exposed to 1.0 ppm O3 for 2 hr released 65 +/- 12% more tritium, derived from [3H]AA, than paired, air-exposed controls into media supernatants. In other studies using a similar O3 exposure protocol, there was also a significant increase in human AM prostaglandin E2 production (2.0 +/- 0.5-fold increase above air-exposure values, p less than 0.01, n = 17). In additional studies, using a similar O3 exposure protocol (1.0 ppm for 1 hr), there was also a significant increase in human AM PAF content (1.7 +/- 0.2-fold increase above air-exposure values, p less than 0.02, n = 5). These potent lipid mediators, originally derived from human AM, may play an important role in the mechanisms of O3 lung toxicity.
Cervello's Treatment of Phthisis
Authors: N. E. Norway
Journal: BMJ (1900)

was found in 20 cases.Occasionally it was accompanied by pyrexia, and on two occasions by pains in the joints.There were also 2 cases with joint pains not accompanied by an erythema, and i case with pain over the lower third of the right femur.Probably the most unusual case was that of a boy, 4 years of age, who received 2,000 units on the first day of illness.Eleven days later he had pyrexia, with slight cardiac irregu- larity, and a crop of wheals developed on thie front of both legs, chiefly below the middle of the tibia.The wheals sub- sided, leaving round purplish haemorrhagic stains, each about the size of a threepenny-piece.The stains gradually faded in two or three days.
Increased Vascularity in Hepatic Hemangiomas Unusual Pattern on Tc-99m RBC Scintigraphy
Authors: RAJEEV PRAKASH
Journal: Clinical Nuclear Medicine (1994)

A case of multiple hepatic hemangiomas is presented in which increased perfusion to the lesions was noted on radionuclide angiography with intense immediate blood pool concentration on Tc-99m RBC scintigraphy. Serial imaging up to 2 hours revealed increasing accumulation of labeled RBC in the lesions. This pattern is not consistent with the classical presentation of perfusion blood pool mismatch seen in liver hemangiomas and probably represents a rare occurrence in the adult patient.
Endosonography-Guided Endoscopic Band Ligation of Dieulafoy’s Malformation: A Case Report
Authors: G. Folvik, L. B. Nesje, A. Berstad, S. Ødegaard
Journal: Endoscopy (2001)

Dieulafoy's vascular malformation may cause serious upper gastrointestinal hemorrhage. The mucosal lesion is usually small, and precise location of the lesion may therefore be difficult. We report a case of Dieulafoy's lesion successfully treated by endoscopic band ligation (EBL) where endoscopic ultrasonography (EUS), including Doppler examination, was applied for accurate diagnosis, guiding EBL and control of treatment.
Abstract P4-04-15: UC San Diego molecular tumor board: Experience in breast cancer
Authors: BA Parker, RB Schwab, TL Helsten, BG Sarah, H Ojeda-Fournier, B Datnow, MC Schwaederle, AC Coutinho, R Kurzrock
Journal: Cancer Research (2013)

Abstract Background: To realize the promise of personalized medicine, it is important to build the infrastructure to match patients to the most promising therapies using evolving genomic information to inform clinical trial and treatment recommendations. Methods: A molecular tumor board was established in December 2012 consisting of representatives of medical oncology, surgery, radiation, pathology, radiology, clinical genetics, molecular genetics and diagnostics, basic and translational science, and bioinformatics and pathway analysis. Patients with metastatic breast cancer signed consent for collection of data in a registry format related to clinical history, genomic analysis, treatment recommendations, and response. Tumor specimens from patients with metastatic breast cancer were subjected to a next generation sequencing diagnostic test (Foundation One™) in a CLIA-certified lab (Foundation Medicine) and analyzed for genomic alterations in a 182 gene panel or a 236 gene panel. Clinical cases and genomic alterations were discussed at Molecular Tumor Board where clinical trials and treatment recommendations were considered, with the final decision made by the treating oncologist. Results: Genomic analyses of metastatic breast cancer specimens from 17 consented patients had at least one genomic alteration and no tumors had the same genomic alterations. 12/17 had ≥ 2 and 4/17 had 6 or 7 genomic alterations. The most common genomic alterations were in PIK3CA observed in tumors from 6/17 patients. 1/17 tumor specimens had only a single genomic alteration for which there are no current targeted drugs in clinical studies or available commercially (GATA3). Radiographic and/or tumor marker response have been observed to date in 3/4 heavily pretreated patients following treatment with a targeted therapy or a targeted therapy informed by the genomic data in combination with other drugs. Conclusions: The strategy of matching targeted clinical trial and commercially available therapies to genomic alterations of tumor specimens from individual patients with metastatic breast cancer may offer promise to patients with advanced refractory disease. Biopsies of metastatic disease, genomic analysis in CLIA labs, establishment of molecular tumor boards, definition of “matched” versus “non-matched” therapies, capturing data in a registry to create a learning environment, and most importantly, availability of targeted therapies in clinical trials or commercially, are required for this individual patient strategy to inform current and future treatment options for much larger patient populations. Funding from UC San Diego Moores Cancer Center MyAnswerToCancer philanthropic fund. Citation Information: Cancer Res 2013;73(24 Suppl): Abstract nr P4-04-15.