tbuckley/cabot-search huggingface dataset:
Abstract 2435: The Role of Myocardial Longitudinal Strain in Monitoring Subclinical Heart Failure in Survivors of Childhood Cancer
Authors: Annelies M Mavinkurve-Groothuis, Jacqueline Groot-Loonen, Louise Bellersen, Ton Feuth, Jos P Bokkerink, Chris L de Korte, Livia Kapusta
Journal: Circulation (2008)

Objectives: Previous studies have demonstrated that myocardial longitudinal strain and strain rate is decreased in asymptomatic patients treated with anthracyclines. In this study, the relation between global myocardial longitudinal strain, conventional echocardiographic parameters, NT-pro-BNP levels, cumulative anthracycline dosage and follow up duration was investigated in a large group of asymptomatic long term survivors of childhood cancer. Methods: 79 asymptomatic survivors (45% children) underwent a detailed echocardiographic examination for obtaining conventional parameters and global myocardial longitudinal strain values in 4-chamber view. In addition to this, we collected blood samples for NT-pro-BNP estimation. Results: the survivors had a mean age of 20 years (range: 6 –37 years), a mean follow up duration of 14 years (range 5–27 years) and a mean cumulative anthracycline dose of 240 mg/m 2 (range 50 –524 mg/m 2 ). Reduced global myocardial longitudinal strain was significantly related to an EF&lt;55% (p&lt;0.001) and to reduced left ventricular posterior wall thickness in diastole indexed by body surface area (LVPWd/BSA) (p&lt;0.003). Reduced myocardial global longitudinal strain was not related to abnormal NT-pro-BNP levels, follow up duration and cumulative anthracycline dosage. Conclusion: reduced global myocardial longitudinal strain is related to subclinical heart failure, e.g. abnormal EF and reduced LVPWd/BSA in asymptomatic survivors of childhood cancer. The role of myocardial strain in the early detection of anthracycline-induced cardiotoxicity needs to be explored by further longitudinal prospective studies.
Results of respiratory parameters in morbidly obese patientes with obstructive sleep apnoea after bariatric surgery
Authors: Amaia Urrutia Gajate, Sandra Pedrero Tejada, Jose Amilibia Alonso, Federico Vazquez San Miguel, Gaizka Errazti De Olartecoechea, Marta Inchausti Iguiñiz, Maria Alfonso Imizcoz, Ruth Diez Arnesto
Journal: European Respiratory Journal (2011)

Background:  Bariatric surgery (BS) is an effective treatment for morbidly obese patients. Our aim is to analyze the sleep breathing parameters after BS in patients with obstructive sleep apnoea (OSA) and the differences between patients who corrected the disorders and patients who did not   Methods:  Morbidly obese and diagnosed of OSA patients, who underwent BS. We analyzed weight-loss and sleep parameters before and after BS. We consider improvement a decrease of 50% in the AHI or AHI after BS ≤10   Results:  52 patients, 41 (79%) women, 11 men (21%), mean age 44.24±9.78 years. 48 (92%) with preBS AHI >10, 4 cases (8%) with SaO2 disorders.  39 cases with AHI postBS ≤10 y 13 cases with IAH >10.  49/52 cases (94%) improved or solved their OSA. In 3 cases the AHI postBS was >10, but improved from severe to mild. 4 cases with SaO2 disorders and AHI  30   Conclusions:  1. BS solved completely the OSA in most of the patients (40/52, 77%) and improved it in all of them. 2. No statistical difference was observed in weight loss before and after BS. 3. Patients with an AHI postBS >10 had a high preBS AHI (mean 66.6), significantly higher than patients with AHI
Survival Benefit of High-Dose Therapy in Poor-Risk Aggressive Non-Hodgkin’s Lymphoma: Concerns About Omissions in the Data Presented
Authors: R.D. Kennedy, R.G. Cuthbert, P.J. Kettle, T.C.M. Morris
Journal: Journal of Clinical Oncology (2001)

Article Tools SPECIAL DEPARTMENTS Article Tools OPTIONS & TOOLS Export Citation Track Citation Add To Favorites Rights & Permissions COMPANION ARTICLES No companion articles ARTICLE CITATION DOI: 10.1200/JCO.2001.19.6.1884 Journal of Clinical Oncology - published online before print September 21, 2016 PMID: 11251023 Survival Benefit of High-Dose Therapy in Poor-Risk Aggressive Non-Hodgkin’s Lymphoma: Concerns About Omissions in the Data Presented R.D. KennedyxR.D. KennedySearch for articles by this author , R.G. CuthbertxR.G. CuthbertSearch for articles by this author , P.J. KettlexP.J. KettleSearch for articles by this author , T.C.M. MorrisxT.C.M. MorrisSearch for articles by this author Show More Queens University of Belfast, Belfast City Hospital, Belfast, Northern Ireland https://doi.org/10.1200/JCO.2001.19.6.1884 First Page Full Text PDF Figures and Tables © 2001 by American Society of Clinical Oncology
Influence of basic therapy of bronchial asthma (BA) on respiratory symptoms in patients with pulmonary TB associated with bronchial asthma
Authors: Galina Kuklina, Evgeny Shmelev
Journal: European Respiratory Journal (2014)

Aim: To study influence of basic therapy of bronchial asthma on respiratory symptoms in patients with pulmonary TB associated with BA.  Methods: We studied influence of modern basic therapy of BA on the course of pulmonary TB in 40 patients with pulmonary TB associated with bronchial asthma: 15 cases of focal TB, 13 cases of infiltrative TB (IT), 12 cases of fibrocavernous TB (FCT).  All the patients received standard therapy of the main disease with TB drugs, as recommended by the WHO. 15 patients received combined therapy with IGCS based on severity of bronchial asthma, one dose of 50/500 mcg of combined IGCS (including prolonged beta2-agonist-salmeterol and fluticasone propionate) twice a day; 6 patients received nebulizer therapy with inhaled GCS, cholinolytics and β 2 -agonists during 6 months; and 2 patients also received a short course of prednisolone – 10 mg/day. 19 controls received euphyllin and short-range beta2-agonists. Clinical symptoms (dyspnea, cough, mycobacteria burden, rales, night asphyxia) were estimated using a 4-score scale followed by calculation of the cumulative index.  Results: We established that basic therapy of bronchial asthma decreased CI by 29.3% in the main group, and by 12.4% in the comparison group; dyspnea decreased by 32.3%, night asphyxia by 62.5% in the main group.  Conclusion: Use of modern basic therapy of BA allowed significantly decreasing expressiveness of respiratory symptoms in patients with pulmonary TB associated with bronchial asthma.
Role of interleukin-2 (IL-2), IL-7, and IL-15 in natural killer cell differentiation from cord blood hematopoietic progenitor cells and from gamma c transduced severe combined immunodeficiency X1 bone marrow cells
Authors: M Cavazzana-Calvo, S Hacein-Bey, G de Saint Basile, C De Coene, F Selz, F Le Deist, A Fischer
Journal: Blood (1996)
Review of<i>Bullets and Brains</i>
Authors: Daniel Utpadel-Fischler
Journal: JAMA Neurology (2015)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Neurology HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Neurology journal
Endoscopic Placement of the Bengmark Tube
Authors: G Constable, J Pappachan, M A Stroud
Journal: Endoscopy (2003)

Upper gastrointestinal intolerance, gastroparesis and high gastric aspirate volumes are commonly encountered in the Intensive Care Unit (ICU) [1], and may be associated with a higher incidence of nosocomial pneumonia, longer ICU stay and increased mortality [2]. High gastric aspirate volumes during intragastric feeding may be interpreted as ”failure of absorption” and result in temporary abandonment of the enteral route. In comparison, postpyloric feeding has been shown to improve nutrient delivery [3], and may also reduce the time required to achieve feeding goals [4]. However, placement of postpyloric feeding tubes is frequently difficult, often requiring multiple attempts, fluoroscopy and endoscopy. In our experience, successful postpyloric tube placement demands the use of radiographic monitoring. Transfer of patients to the radiography department is often not possible and, moreover, fluoroscopy is not practicable in the ICU. Successful placement by endoscopy alone may be limited by displacement and reflux back into the stomach, both as the scope is withdrawn and later as a result of retrograde peristalsis. Wire-guided systems may overcome placement problems to some extent but necessitate difficult oral-to-nasal transfer of the wire. Such difficulties can significantly delay postpyloric access and may prompt prolonged parenteral support.
Changing prevalence of indolent lymphoid malignancies among the elderly
Authors: W. T. Swenson
Journal: Journal of Clinical Oncology (2006)

7579 Background: Reported changes in incidence rates and improved survival rates among patients with common indolent B-cell lymphoid malignancies have potential implications for increased disease burden among the elderly. This study examines incidence, survival, and prevalence rates of elderly patients with follicular lymphoma (FL) and CLL/SLL using a large population based database. The indolent and incurable nature of these diseases makes the prevalence rate a good indicator of total disease burden. Methods: The SEER 9 public use database was analyzed using SEER*Stat software version 6.1.4. Subjects were identified by ICD-O-3 diagnostic codes. Incidence rates and trends (from 1973 to 2002) were calculated (per 100,000 population) and were age-adjusted to the 2000 US standard population. Survival rates were calculated for patients diagnosed during the periods 1980–1985 and 1990–1995. Prevalence rates include patients diagnosed within 15 years prior to the prevalence date (15-year limited prevalence). Results: Annual percent change of incidence rate (per 100,000) among patients ≥65 years (from 1973 to 2002) was 2.76 (95% CI: 1.92, 3.60) for FL and -0.18 (95% CI: -0.47, 0.11) for CLL/SLL. Survival rates for patients ≥65 years was improved for both FL and CLL/SLL. Among patients with FL diagnosed between 1975–1980 and 1990–1995, 5-year survival rates were 42.2% (95% CI: 38.8, 45.6) and 50.3% (95% CI: 47.9, 52.7). Among patients with CLL diagnosed between 1975–1980 and 1990–1995, 5-year survival rates were 40.6% (95% CI: 38.8, 42.4) and 50.4% (95% CI: 48.9, 51.9). Prevalence percent increased for FL patients among ages 65–74 years, 75–84 years, and ≥85 years. Prevalence percents were unchanged among CLL/SLL patients. Conclusions: Increased FL incidence and increased survival rates have resulted in a growing disease burden among the elderly over the last decade; the prevalence of CLL/SLL has remained static. [Table: see text] No significant financial relationships to disclose.
Chronic airway inflammation alters the peripheral distribution of transferred mast cells in deficient C57BL/6-KitW-sh/W-sh mice
Authors: Lisa Sjöberg, Barbara Fuchs, Christine Möller Westerberg, Linda Swedin, Sven-Erik Dahlén, Mikael Adner, Gunnar Nilsson
Journal: European Respiratory Journal (2011)

Mast cells (MC) play important roles in chronic inflammatory diseases such as asthma. This study tested if transfer of bone-marrow derived MC (BMMC) to the lung could provide a new method to explore MC involvement in chronic allergic airway inflammation (CAAI).  We addressed this issue by comparing MC-distribution in wild-type C57BL/6 (WT), Wsh (MC-deficient) and intravenously BMMC-transferred Wsh (Wsh+MC) mice. CAAI was induced by ovalbumin/alum injections and challenges during 90 days. Lung sections were histochemically stained to detect MC.  In control mice, number of MC in the lungs was significantly higher in Wsh+MC [MC/section; Mean±SEM, 36±4] compared to WT [2±1]. No MCs were detected in Wsh mice. MC in WT mice were located around the central airway (CA) [1±0] and in the perivascular space (PVS) [1±0] whereas they were negligible in parenchyma (PA) and smaller airways (SA). In contrast, MCs in Wsh+MC mice were predominantly found in PA [16±2] and PVS [15±2] but also around CA [3±1] and SA [3±1]. Induction of CAAI in Wsh+MC mice caused increased MC number in the PA [28±6 vs. 16±2] and decreased MC number in the CA [0±0 vs. 3±1] and PVS [5±1 vs. 15±2] compared to controls. Importantly, these findings suggest that MC transfer causes a completely different condition, which might not be comparable to the WT and thus not serve as an adequate control. Instead, Wsh+MC mice may be more suitable in experiments for studying CAAI, since mast cell number, distribution and relocation in response to inflammation more closely resemble findings in the human lung.
MiR-31 regulates IRF-1 function in cystic fibrosis epithelial cells
Authors: Sinead Weldon, Irene Ogelsby, Christine Wohlford-Lenane, Jennifer Bartlett, Gerry McElvaney, Catherine Greene, Paul McCray, Clifford Taggart
Journal: European Respiratory Journal (2014)

MicroRNAs (miRNAs) are short non-coding RNAs that modulate target gene expression via translational repression or degradation of their target RNAs. MiRNAs may regulate up to one-third of all protein coding genes in human genome and dysregulation of miRNAs may contribute to cystic fibrosis (CF) pathology. Recent work has identified unique miRNA profiles in the CF lung and analysis of target genes has revealed important roles for miRNAs in the regulation of CFTR expression and function and inflammation. MiR-31 is one of the most highly expressed miRNAs present in human non-CF airway epithelial cells but its role in pulmonary epithelial cell function is unknown. In this study, we evaluated miR-31 expression in CF pulmonary epithelial cells and found that miR-31 levels were significantly decreased in CF tracheal and bronchial epithelial cell lines, primary epithelial cells and bronchial brushings compared to non-CF controls.  In silico  analysis predicted that the transcription factor IRF-1 was a target of miR-31 and overexpression of miR-31 in CF bronchial epithelial cells (CFBEs) resulted in a decrease in the levels of IRF-1. Furthermore, this decrease in IRF-1 was associated with a significant decrease in the expression and production of the IRF-1 target gene, the cysteine cathepsin, cathepsin S. The miR-31/IRF-1/CTSS pathway may play a functional role in the pathogenesis of CF lung disease and may open up new avenues for exploration in the search for an effective therapeutic target.
Foodborne outbreaks in northern Portugal, 2002
Authors: A  M Correia, G Gonçalves, Margarida Saraiva
Journal: Eurosurveillance (2004)

In October 2001, foodborne outbreaks (FBO) were included in the Portuguese alert and response surveillance system. Accordingly, the northern regional health authority (Delegado Regional de Saude do Norte--DRSN) began a surveillance programme of foodborne outbreaks. This report is a brief description of data generated from this programme in 2002. For each foodborne outbreak the local health authority (Delegado de Saude Concelhio--DSC) produced a written report. Fifty-nine percent of the 27 FBOs studied by DSCs during 2002 were reported within 72 hours after the date of onset. Five hundred and seventy seven people became ill, 9.6% of the patients were admitted to hospital, and no deaths were reported. The aetiological agent was identified from patients in 63% of FBOs, and in food items in 18.5% of the situations. Salmonella enterica was responsible for 73.7% of the outbreaks in which the agent was laboratory confirmed. Meals implicated in the outbreak were mainly prepared in restaurants and private homes (75.0% of FBO). Inadequate processing, preparing or handling of foods were the contributing factors more often reported by the DSC. We believe that epidemiological surveillance and control of FBO must be reinforced in Portugal as part of a wider strategy to promote food safety.
Effects of intraoperative radiotherapy on breast cancer cell proliferation and invasion
Authors: Barbara Belletti, Sara D'Andrea, Tiziana Perin, Alfonso Colombatti, Samuele Massarut, Gustavo Baldassarre
Journal: Clinical Cancer Research (2008)

AACR Centennial Conference: Translational Cancer Medicine-- July 20-23, 2008; Monterey, CA

B7 

Cancer recurrence and metastasis formation represent the principal causes of morbidity and mortality of malignant tumors. In human breast carcinoma, after conserving surgery, most recurrences occur in the tissue surrounding the original tumor, suggesting that surgery and/or primary tumor microenvironment could influence the growth and invasion of breast cancer cells.    To test whether and how the tumor microenvironment had specific roles in inducing cancer cells recurrence, we collected blood samples (BS) and surgical wound fluids (WF) from patients in the 24 hours following breast conserving surgery, and test the potential of these sera to promote cancer cell proliferation, motility and invasion. About 50% of these WFs were harvested from patients also treated with localized intra-operative radiotherapy (IORT) immediately after the surgical excision.    Our data suggest that WFs are more efficient in promoting proliferation, migration and invasion of a panel of breast carcinoma cell lines than the respective BS. Interestingly, the stimulatory effect on cell migration, invasion and cell growth in tridimensional matrices was almost completely abrogated when IORT-WFs were assayed.    Following exposure to the WFs, breast cancer cells efficiently activated the most common signal transduction pathways. Yet, in the same time course experiments, IORT-WFs resulted much less effective in promoting the activation of some key pathways, particularly those of p70S6K and of STAT3.    Our present data strongly indicate that targeted IORT delivered to the tumor bed can alter the composition of the pool of cytokines and growth factors in the surgical wound. This, in turn, can decrease the stimulatory effects of the wound fluid on cancer cell growth and motility, which eventually affects the occurrence of cancer recurrences and metastasis formation.
Detection of bronchial asthma using impulse oscillation system (IOS) in patients with normal spirometry
Authors: Roberto Lipsi, Anna Chiara Ogliari, Alice Biffi, Alessandra Cimino, George Cremona
Journal: European Respiratory Journal (2012)

Background: The gold standard for the diagnosis of bronchial asthma in patients with a normal spirometry is currently the bronchial provocation test. IOS is a promising technique to assess airway function being simple to perform and able to quantify changes in peripheral airway resistance undetected by traditional spirometry.  Aim & Methods: In order to assess whether IOS could be useful in detecting asthma in subjects with a normal spirometry, 23 (9 female, mean age 37 SD 17 years) non smoking patients referred for methacholine challenge testing (MCT) for chronic rhinitis or cough were studied by spirometry and IOS prior to MCT. All tests were performed on the same day in separate study rooms by different technicians blind to the results.  Results: Mean baseline FEV1 was 87 SD 10% of predicted. Ten subjects had a positive MCT with a mean PD20 dose of 0,5 SD 0,4 mgl -1. IOS showed higher baseline R5-20Hz values in MCT+ subjects (0,86±0,71 vs 0,27±0,14 cmH2O/l/s; p  Consclusion: We conclude that Rp may be a useful marker in predicting MCT response and provide a screening tool for detecting bronchial asthma.
Clinical Experience of Clerks and Dressers: A Three-Year Study of Birmingham Medical Students
Authors: D N J Lockwood, L H Goldman, I C McManus
Journal: Journal of the Royal Society of Medicine (1986)

A survey of the clinical experience of junior medical clerks and surgical dressers on their first clinical attachment in the Birmingham University Teaching Hospitals was organized by students over a three-year period. A typical clinical student had performed basic clinical procedures such as putting up a drip, doing an ECG, bladder catheterization and seen a wide range of other procedures. Most students felt involved in the work of the firm, had clerked routine admissions, and regularly attended the firm's emergency admission night. Consultants on most firms were felt to be concerned about student progress. Students attached to district general hospitals gained a wider range of clinical experience than those at established teaching hospitals. Student-run audit is a useful way of monitoring the clinical experience gained by medical students.
Mechanisms of hTERT up-regulation during immortalization of human mammary epithelial cells
Authors: Ekaterina Bassett, James C. Garbe, Tarlochan Nijjar, Martha R. Stampfer, Paul Yaswen
Journal: Cancer Research (2006)

4987  Immortality is a prerequisite for the accumulation of multiple malignant changes in a single cell lineage during human breast carcinogenesis. We use cultured human mammary epithelial cells (HMEC) to study changes contributing to immortalization. Following treatment with carcinogen, benzo(a)pyrene, extremely rare HMEC achieved immortalization. Early passages of the immortal HMEC line 184A1, expressing wild-type p53, initially displayed very low telomerase activity, but continued to divide until the cells attained mean TRF lengths of 3 kb or less. At this point, the cultured cells reproducibly entered a period of slow, heterogeneous growth termed conversion, which was accompanied by accumulation of the cyclin-dependent kinase inhibitior p57KIP2. When the p53-inhibiting genetic suppressor element 22 (GSE22) was transduced into the cells prior to the onset of conversion, hTERT mRNA was rapidly induced and telomerase activity was up-regulated, indicating that telomerase expression in the newly immortalized HMEC was suppressed by endogenous p53. As conversion of 184A1 progressed, p57KIP2 was dowregulated, and p53-mediated repression of hTERT was presumably alleviated. Current experiments include: 1) investigating the role of p57KIP2 in hTERT regulation by introducing shRNA to p57KIP2 into 184A1 HMEC before and during conversion, 2) measuring the timing of hTERT activation following inhibition of p53 by GSE22, as a first step in determining the mechanism of p53-mediated repression of hTERT, and 3) testing the hypothesis that alterations in chromatin configuration of the hTERT promoter may be necessary for de-repression of hTERT as 184A1 cells undergo conversion to full immortality. In the latter experiments, we are examining the effects of the histone deacetylase inhibitor, trichostatin A (TSA), on pre-conversion 184A1 cells in the presence and absence of transcriptional regulators such as c-myc. By examining the mechanisms of hTERT de-repression during HMEC immortalization, we expect to gain further understanding of rate-limiting processes taking place during early breast carcinogenesis.