tbuckley/cabot-search huggingface dataset:
Noninvasive assessment of left ventricular function from the mitral valve echogram. Relation of final anterior mitral leaflet closing velocity to peak dp/dt and aortic velocity.
Authors: B I Jugdutt, S J Lee, D McFarlane
Journal: Circulation (1978)

Since final mitral valve (MV) closure and aortic ejection velocity are mediated by the same forces in early left ventricular (LV) contraction, the rate of final MV closure (BC slope) should reflect LV performance. We first verified whether peak final closing velocity (ds/dt) of the anterior MV leaflet (AMVL) is related to peak aortic ejection velocity (V) and LV dp/dt in 18 open-chest dogs. We then checked the validity of the relations in man. Our approach was to measure peak ds/dt, peak aortic acceleration (dV/dt) and peak LV dp/dt using electronic differentiation of analog signals of the AMVL echogram, V and LV pressure. In dogs, resting ds/dt averaged 26.9 +/- 9.0 (SD) cm/sec and changed significantly (P less than 0.001) after isoproterenol, propranolol, coronary ligation and aortic cross-clamping. We found good (P less than 0.001) correlations between ds/dt and V (r = 0.82), dV/dt ( r = 0.67) and dp/dt (r = 0.73). In man, resting ds/dt averaged 25.5 +/- 1.6 cm/sec in six normals. In 40 patients with coronary artery disease, restind ds/dt was lower (15.7 +/- 4.4 cm/sec; P less than 0.001) in the 19 with resting LV end-diastolic pressure (LVEDP) greater than 12 mm Hg. Resting ds/dt correlated closely with V (r = 0.82, N = 10), dp/dt (r = 0.93, N = 6), resting LVEDP (r = -0.67, N = 40), angiographic ejection fractions (r = 0.62, N = 40) as well as manually obtained BC slopes (r = 0.93, N = 40). Thus, final MV closing velocity provides a useful and simple means for the objective noninvasive assessment of LV performance.
Electrode-catheter arrhythmia induction in the selection and assessment of antiarrhythmic drug therapy for recurrent ventricular tachycardia.
Authors: J W Mason, R A Winkle
Journal: Circulation (1978)

We performed intracardiac electrophysiologic studies in 33 patients with recurrent ventricular tachycardia. Nineteen patients underwent one, 10 patients two, and four patients three serial electrophysiologic studies. Ventricular tachycardia was successfully induced in 83% of the patients, and pacing methods were successful in terminating tachycardia in 71% of the studies, although pacing-induced acceleration of ventricular tachycardia occurred at least once in 36% of the studies. Seventeen of the 33 patients (52%) required a total of 24 external direct current cardioversions during study. In 21 patients a variety of antiarrhythmic drugs were given I.V. and attempts at ventricular tachycardia induction were repeated to assess prophylactic effects of the drugs. An acutely effective drug or combination of drugs was found in 15 of the patients (71%). Fourteen of the 15 were placed on chronic oral therapy with the effective agent and were followed for an average period of 8.1 months (range one to 33 months). In all 14 patients we could document complete (13 patients) or partial (one patient) long-term prophylaxis against ventricular tachycardia. We conclude that drug efficacy trials in patients with recurrent ventricular tachycardia using intracardiac pacing techniques is a rapid and accurate method of selecting effective long-term antiarrhythmic therapy.
Left Heart Catheterization
Authors: V. O. BJORK, G. MALMSTROM
Journal: Circulation Research (1954)

Direct puncture of the left atrium with a needle, through which a catheter can be passed, allows pressure measurements in atrium, left ventricle and aorta.This procedure is considered to be more helpful than right heart catheterization in evaluation of patients with mitral and aortic valvular lesions.
De la forme culturelle au vécu d’un problème psychopathologique dans un groupe de possession au Zaire: Les Zebola
Authors: Ellen Corin
Journal: Psychotherapy and Psychosomatics (1978)

Research Articles| February 16 2010 De la forme culturelle au vécu d'un problème psychopathologique dans un groupe de possession au Zaire: Les Zebola Subject Area: Psychiatry and Psychology Ellen Corin Ellen Corin Kinshasa Search for other works by this author on: This Site PubMed Google Scholar Psychother Psychosom (1978) 29 (1-4): 325–329. https://doi.org/10.1159/000287154 Article history Published Online: February 16 2010 Content Tools Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Facebook Twitter LinkedIn Email Tools Icon Tools Get Permissions Cite Icon Cite Search Site Citation Ellen Corin; De la forme culturelle au vécu d'un problème psychopathologique dans un groupe de possession au Zaire: Les Zebola. Psychother Psychosom 31 December 1978; 29 (1-4): 325–329. https://doi.org/10.1159/000287154 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAll JournalsPsychotherapy and Psychosomatics Search Advanced Search This content is only available via PDF. 1978Copyright / Drug Dosage / DisclaimerCopyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher.Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. Article PDF first page preview Close Modal You do not currently have access to this content.
Guidance offers little in the way of ethics or transparency
Authors: W. Rogers, T. Zutlevics, M. Raven, J. Jureidini
Journal: BMJ (2012)

While noting the alleged benefits of this new guidance, the article fails to mention its weaknesses.1 The guidance uncritically endorses relationships between the drug industry and healthcare professionals, a view endorsed by 18 august bodies including various royal colleges.

Despite claims of “ethics, transparency, partnership,” it takes some sleuthing to discover that the guideline is written by a multi-stakeholder group, seemingly coordinated and supported …
How can good performance among doctors be maintained?
Authors: M. West
Journal: BMJ (2002)

A new syndrome of neonatal convulsions is described. Ninety cases were documented from one maternity hospital between 1973 and 1977. The appearance of this syndrome increased the annual incidence of neonatal convulsions from fewer than 3 to more than 16 per 1000 live births. Fits began on about the fifth day in apparently healthy babies. Investigations and therapeutic trials have not shown the cause. There were no deaths and all babies were discharged from hospital apparently well. The term fifth day fits is suggested with criteria for this diagnosis.
Combined intensive blood pressure and glycemic control does not produce an additive benefit on microvascular outcomes in type 2 diabetic patients
Authors: Faramarz Ismail-Beigi, Timothy E. Craven, Patrick J. O'Connor, Diane Karl, Jorge Calles-Escandon, Irene Hramiak, Saul Genuth, William C. Cushman, Hertzel C. Gerstein, Jeffrey L. Probstfield, Lois Katz, Ulrich Schubart
Journal: Kidney International (2011)
Factor V Leiden Mutation and the Risks for Thromboembolic Disease: A Clinical Perspective
Authors: Daniel T. Price
Journal: Annals of Internal Medicine (1997)

Background: A single point mutation in the gene coding for coagulation factor V results in a form of factor Va that is resistant to degradation by activated protein C and leads to a relative hypercoagulable state. This mutation, factor V Leiden, is found in 4% to 6% of the U.S. population. Purpose: To review clinical data on factor V Leiden mutation, with emphasis on prevalence of and risks for thromboembolism and implications for screening and management. Data Sources: A MEDLINE search of the English-language literature published between 1993 and April 1997 and an extensive bibliography review. Study Selection: Case-control and prospective cohort studies were reviewed if clinical features of thromboembolic disease associated with factor V Leiden mutation or resistance to activated protein C were presented. Original research articles were reviewed if they addressed the identification of the laboratory abnormality of activated protein C or factor V Leiden mutation. Case reports and case series were reviewed when no analytic data were available. Data Extraction: Review of the identified articles. Data Synthesis: Factor V Leiden mutation is associated with three- to sixfold increases in risks for primary and recurrent venous thromboembolism, especially in patients without transient risk factors, such as surgery or trauma. Risks for venous thromboembolism in genetically affected persons are substantially higher among patients with coexistent predispositions for thrombosis, such as advanced age, use of oral contraceptives, hyperhomocystinemia, and deficiencies of protein C and protein S. Factor V Leiden mutation does not seem to increase risks for arterial thrombosis. Whether patients with the mutation would benefit from more intense or prolonged anticoagulation is unknown. Conclusions: The presence of factor V Leiden mutation predisposes patients to venous thromboembolism, but screening for this disorder is of uncertain utility. Decisions about whether to screen for the mutation will depend on the results of clinical trials designed to evaluate the benefit-to-risk ratio of long-term anticoagulation in the secondary prevention of venous thromboembolism in patients with resistance to activated protein C.
A CASE OF CONGENITAL MUCOUS POLYPUS OF THE NOSE—WITH REMARKS.
Authors: DUNBAR ROY
Journal: JAMA (1895)

It is not my intention in this short article to go into the minute discussion of that pathologic condition known as mucous polypi of the nasal cavities, nor to adduce any new and original method for their eradication which has not already been brought before the profession at large; but with a few prefatory remarks I wish to report the history of a case of congenital nasal mucous polypus which is of sufficient rarity to render its report not entirely inappropriate for this Section. The subject of nasal polypi is an old one and perhaps the first morbid condition of these cavities which was undertaken to be rectified by the surgeon and physician alike, since its presence was perhaps the easiest recognized of all diseased states of the nasal cavities. Our medical periodicals and society reports have for the last few years teemed with articles upon the etiology and best
Maternal Levels of Plasma Human Immunodeficiency Virus Type 1 RNA and the Risk of Perinatal Transmission
Authors: Patricia M. Garcia, Leslie A. Kalish, Jane Pitt, Howard Minkoff, Thomas C. Quinn, Sandra K. Burchett, Janet Kornegay, Brooks Jackson, John Moye, Celine Hanson, Carmen Zorrilla, Judy F. Lew
Journal: New England Journal of Medicine (1999)

The importance of plasma levels of human immunodeficiency virus type 1 (HIV-1) RNA in pregnant women in relation to the other factors known to influence the risk of transmission of infection to their infants is incompletely defined. We studied the relation of maternal plasma HIV-1 RNA levels to the risk of perinatal transmission and the timing of transmission.
Further evidence for increased light sensitivity in patients with malignant melanoma
Authors: HARRY BEITNER, ULRIK RINGBORG, GORAN WENNERSTEN, BENGT LAGERLOF
Journal: British Journal of Dermatology (1981)

Minimal erythema dose (MED), immediate pigment darkening (IPD) and skin typing were performed on 130 patients with malignant melanoma and on seventy-three controls. The tumours were histologically classified according to Clark as superficial spreading melanoma, nodular melanoma, and lentigo maligna melanoma. The tumours of twelve patients were not possible to classify. Patients belonging to skin type IV and patients with lentigo maligna melanoma had a significantly higher mean age. The IPD reaction was significantly higher in skin type II than in skin types III and IV both in patients and in controls. IPD and MED showed no significant correlation to age and sex. MED was significantly lower among patients with malignant melanoma than controls. These data indicate that light sensitivity is of aetiological importance in malignant melanoma.
SCHISTOSOME DERMATITIS IN THE UNITED STATES (MICHIGAN)
Authors: W. W. CORT
Journal: JAMA (1928)

For a number of years, cases of dermatitis of unknown etiology have developed at the University of Michigan Biological Station on Douglas Lake, Mich., in persons who have waded in certain places for the collection of biologic specimens. A similar condition has also been noted at certain summer resorts in the same general region. While there has been a considerable amount of speculation and some experimentation on the cause of this dermatitis, the first definite evidence was obtained during the past summer, when lesions similar to those contracted from wading were produced experimentally by placing on the surface of the skin schistosome cercariae belonging to a species described by Miller<sup>1</sup>in 1923 as<i>Cercaria elvae</i>. While it has not been established that this cercaria is the only factor in the production of the dermatitis of the region, the evidence available indicates that it is an important causative agent. The
CARDIOPROTECTIVE EFFECT OF ALLOGENEIC CARDIOSPHERE–DERIVED CELLS: REDUCTION OF INFARCT SIZE AND ATTENUATION OF NO–REFLOW WHEN ADMINISTERED IN THE INFARCT–RELATED ARTERY AFTER REPERFUSION IN PIGS WITH ACUTE MYOCARDIAL INFARCTION
Authors: Hideaki Kanazawa, Konstantinos Malliaras, Kristine Yee, James Dawkins, Eleni Tseliou, Linda Marbán, Rajendra Makkar, Eduardo Marban
Journal: Journal of the American College of Cardiology (2013)
Radiation Exposures from the Use of Shoe-Fitting Fluoroscopes
Authors: Charles R. Williams
Journal: New England Journal of Medicine (1949)

IT IS now common practice in many shoe stores and shoe departments of department stores to supplement usual shoe-fitting methods by the use of fluoroscopes known as x-ray shoe fitters. Because this technic has spread rapidly throughout the United States, particularly in stores specializing in children's shoes, it is desirable to know precisely the exposures to irradiation received by customers, as well as by clerks and other persons in the area of x-ray shoe-fitting units.For this reason a series of studies was undertaken for the purpose of measuring foot dosage, leakage through the walls of the cabinet and scattering . . .
Kinetoplastids: related protozoan pathogens, different diseases
Authors: Ken Stuart, Reto Brun, Simon Croft, Alan Fairlamb, Ricardo E. Gürtler, Jim McKerrow, Steve Reed, Rick Tarleton
Journal: Journal of Clinical Investigation (2008)

Kinetoplastids are a group of flagellated protozoans that include the species Trypanosoma and Leishmania, which are human pathogens with devastating health and economic effects. The sequencing of the genomes of some of these species has highlighted their genetic relatedness and underlined differences in the diseases that they cause. As we discuss in this Review, steady progress using a combination of molecular, genetic, immunologic, and clinical approaches has substantially increased understanding of these pathogens and important aspects of the diseases that they cause. Consequently, the paths for developing additional measures to control these “neglected diseases” are becoming increasingly clear, and we believe that the opportunities for developing the drugs, diagnostics, vaccines, and other tools necessary to expand the armamentarium to combat these diseases have never been better.
The Health Care 'Team'?-Reply
Authors: Emil P. Taxay
Journal: JAMA (1978)

The editors have graciously allowed me to reply to those who have responded to my recent note. My personal mail has been flattering; not soThe Journal's. Of interest is the fact that 80% of my mail (300 letters in six weeks) has come from university-based physicians. These are undoubtedly the more long-suffering of those who have been "advised" of their "position" on the team. In the penultimate paragraph of the criticism accompanying this reply, Dr Etzwiler states that "if we [physicians] choose not to accept..., there are others who can, are willing, and perhaps should assume such a position." Without any false humility whatsoever, I reply, "Who are they?"
Comparison of Ivermectin and Diethylcarbamazine in the Treatment of Onchocerciasis
Authors: Bruce M. Greene, Hugh R. Taylor, Eddie W. Cupp, Robert P. Murphy, Albert T. White, Mohammed A. Aziz, Hartwig Schulz-Key, Salvatore A. D'Anna, Henry S. Newland, Leonard P. Goldschmidt, Cheryl Auer, Aloysius P. Hanson, S. Vaanii Freeman, Earl W. Reber, P. Noel Williams
Journal: New England Journal of Medicine (1985)

We compared ivermectin with diethylcarbamazine for the treatment of onchocerciasis in a double-blind, placebo-controlled trial. Thirty men with moderate to heavy infection and ocular involvement were randomly assigned to receive ivermectin in a single oral dose (200 micrograms per kilogram of body weight), diethylcarbamazine daily for eight days, or placebo. Diethylcarbamazine caused a significantly more severe systemic reaction than ivermectin (P less than 0.001), whereas the reaction to ivermectin did not differ from the reaction to placebo. Diethylcarbamazine markedly increased the number of punctate opacities in the eye (P less than 0.001), as well as the number of dead and living microfilariae in the cornea over the first week of therapy. Ivermectin had no such effect. Both ivermectin and diethylcarbamazine promptly reduced skin microfilaria counts, but only in the ivermectin group did counts remain significantly lower (P less than 0.005) than in the placebo group at the end of six months of observation. Analysis of adult worms isolated from nodules obtained two months after the start of therapy showed no effect of either drug on viability. Ivermectin appears to be a better tolerated, safer, and more effective microfilaricidal agent than diethylcarbamazine for the treatment of onchocerciasis.
Transplantation of myoblast sheets that secrete the novel peptide SVVYGLR improves cardiac function in failing hearts
Authors: Ayako Uchinaka, Naomasa Kawaguchi, Yoshinosuke Hamada, Seiji Mori, Shigeru Miyagawa, Atsuhiro Saito, Yoshiki Sawa, Nariaki Matsuura
Journal: Cardiovascular Research (2013)

Transplantation of myoblast sheets is a promising therapy for enhancing cardiac function after heart failure. We have previously demonstrated that a 7-amino-acid sequence (Ser-Val-Val-Tyr-Gly-Leu-Arg) derived from osteopontin (SV peptide) induces angiogenesis. In this study, we evaluated the long-term therapeutic effects of myoblast sheets secreting SV in a rat infarction model.Two weeks after ligation of the left anterior descending coronary artery, the animals were divided into the following three groups: a group transplanted with wild-type rat skeletal myoblast sheets (WT-rSkMs); a group transplanted with SV-secreting myoblast sheets (SV-rSkMs); and a control group (ligation only). We evaluated cardiac function, histological changes, and smooth muscle actin (SMA) expression through transforming growth factor-β (TGF-β) signalling. The ejection fraction and fractional shortening were significantly better, and the enlargement of end-systolic volume was also significantly attenuated in the SV-rSkM group. Left ventricular remodelling, including fibrosis and hypertrophy, was significantly attenuated in the SV-rSkM group, and SV secreted by the myoblast sheets promoted angiogenesis in the infarcted border area. Furthermore, many clusters of SMA-positive cells were observed in the infarcted areas in the SV-rSkM group. In vitro SMA expression was increased when SV was added to the isolated myocardial fibroblasts. Moreover, SV bound to the TGF-β receptor, and SV treatment activated TGF-β receptor-Smad signalling.The SV-secreting myoblast sheets facilitate a long-term improvement in cardiac function. The SV can induce differentiation of fibroblasts to myofibroblasts via TGF-β-Smad signalling. This peptide could possibly be used as a bridge to heart transplantation or as an ideal peptide drug for cardiac regeneration therapy.
Stealth Rare Earth Oxide Nanodiscs for Magnetic Resonance Imaging
Authors: Mark J. Bailey, Rob van der Weegen, Piper J. Klemm, Suzanne L. Baker, Brett A. Helms
Journal: Advanced Healthcare Materials (2012)

Configuring RE2O3 nanocrystals with pseudo-2D morphologies confers substantive gains in relaxivities over equivalent spherical counterparts. The most promising arises from Gd2O3 whose ionic transverse and longitudinal relaxivities were as high as r1 = 12.7 mM−1 s−1 and r2 = 17.2 mM−1 s−1 (dispersed in H2O, T = 37 °C & B0 = 1.41 T), pointing to new opportunities to achieve high contrast MRI while concomitantly affording longer half-life potential in vivo. Detailed facts of importance to specialist readers are published as "Supporting Information". Such documents are peer-reviewed, but not copy-edited or typeset. They are made available as submitted by the authors. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
Matrix metalloproteinases and their inhibitors in premature coronary atherosclerosis: Relation with inflammation and metabolic markers
Authors: Samuele Nanni, Giovanni Melandri, Roeland Hanemaaijer, Vittorio Cervi, Luciana Tomasi, Chiara Melloni, Pierluigi Tricoci, Angelo Branzi
Journal: Journal of the American College of Cardiology (2003)
Stimulation of rat hepatocyte fibronectin production by monocyte-conditioned medium is due to interleukin 6.
Authors: M E Lanser, G E Brown
Journal: The Journal of Experimental Medicine (1989)

In this report, conditioned media from LPS-stimulated monocytes increased rat hepatocyte production of fibronectin (Fn) in a dose-dependent manner. Preincubation of the conditioned media with anti-IL-6, but not with anti-IL-1 alpha, anti-IL-1 beta, or anti-TNF, completely neutralized the Fn-stimulating activity. 10-100 pg/ml of rIL-6 was sufficient to increase Fn production. Neither IL-1 nor TNF had an effect on Fn production. The Fn-stimulating activity of IL-6 could be specifically neutralized only with anti-IL-6, but not with anti-IL-1 or anti-TNF. The increased Fn produced was shown to be of the plasma rather than the cellular form. These results demonstrate that IL-6 is the factor in monocyte-conditioned media that stimulates Fn production, and that IL-6 is the monokine tested with such activity.