tbuckley/cabot-search huggingface dataset:
Thyroid Hormones and the Acquired Immunodeficiency Syndrome (AIDS)
Authors: James W. Findling
Journal: Annals of Internal Medicine (1989)

Letters and Corrections1 December 1989Thyroid Hormones and the Acquired Immunodeficiency Syndrome (AIDS)James W. Findling, MD, Brian P. Buggy, MDJames W. Findling, MDSearch for more papers by this author, Brian P. Buggy, MDSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-111-11-951_1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the Editor: LoPresti and colleagues (1) recently described unique alterations in thyroid hormone indices in patients with the acquired immunodeficiency syndrome (AIDS). They reported elevations of thyroid binding globulin which reflected the progression of the underlying human immunodeficiency virus (HIV) infection; however, they did not describe frank elevations of serum thyroxine (T4) in their patients, presumably due to other factors known to lower T4 in patients with chronic or acute nonthyroidal illnesses. We report two patients with AIDS and significant euthyroid hyperthyroxinemia resulting from increases in thyroid binding globulin.Patient 1. A 60-year-old man with hemophilia A and transfusion-related...References1. LoPrestiFriedSpencerNicoloff JJCJ. Unique alterations of thyroid hormone indices in the acquired immunodeficiency syndrome (AIDS). Ann Intern Med. 1989;110:970-5. LinkGoogle Scholar2. Utiger R. The thyroid: physiology, hyperthyroidism, hypothyroidism, and the painful thyroid. In: Felig P, Baxter JD, Broadus AE, Frohman LA, eds. Endocrinology and Metabolism. 2d ed. New York: McGraw-Hill; 1987:389-472. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: St. Luke's Medical Center Milwaukee, WI 53215 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited By7 Thyroid dysfunction in HIV infectionHypothyroid-like regulation of the pituitary-thyroid axis in stable human immunodeficiency virus infectionEndocrine Complications of AIDS and Drug AddictionElevation of serum thyroxine-binding globulin (but not of cortisol-binding globulin and sex hormone-binding globulin) associated with the progression of human immunodeficiency virus infection 1 December 1989Volume 111, Issue 11Page: 951-951KeywordsAIDSGlobulinsHIVHIV infectionsHemophilia AHyperthyroxinemiaThyroidThyroid hormonesThyroxine Issue Published: 1 December 1989 PDF DownloadLoading ...
Paroxysmal supraventricular tachycardia in patients with mitral valve prolapse.
Authors: M E Josephson, L N Horowitz, J A Kastor
Journal: Circulation (1978)

The mechanism of supraventricular tachycardia was evaluated in twelve patients with mitral valve prolapse utilizing standard intracardiac recording and stimulation techniques. Eight patients had normal electrocardiograms, three had a short PR interval and normal QRS (Lown-Ganong-Levine syndrome) and one had Wolff-Parkinson-White type A. Six of the eight patients with normal electrocardiograms were demonstrated to have atrioventricular bypass tracts. Five patients had A-V nodal re-entrant supraventricular tachycardia. In two patients the bypass tract could be demonstrated to conduct antegradely when the left atrium was paced via the coronary sinus, while in four the bypass tract only conducted retrogradely. In all seven patients with atrioventricular bypass tracts, the accessory pathway was left-sided. We conclude that a) supraventricular tachycardia in the mitral valve prolapse syndrome appears related to a high frequency of bypass tracts; b) electrophysiological studies are required to diagnose these bypass tracts; and c) the atrioventricular bypass tracts may be related to the mitral valve abnormality since they are always left-sided.
Eosinophil Counting: A Modification of Pilot's Method
Authors: J. C. W. MacFarlane, G. W. Cecil
Journal: BMJ (1951)

MBDTImSHRNAL 1187 pituitary adrenal mechanism is still a matter for specula- tion.At this stage, however, it is sufficient to note that the eosinopenic response to A.C.T.H. and oral cortisone in normal subjects can be usefully compared, and it remains to be seen whether the application of a combined A.C.T.H.-cortisone response test to patients with rheumatic, endocrine, and other diseases will give information of practical value. SummaryA convenient modification of Dunger's technique for estimating the number of circulating eosinophils has been described and shown to be accurate enough for experi- mental purposes.By the use of this technique the eosinopenic responses to single doses of oral cortisone and intra- muscular A.C.T.H. have been studied in some detail in four normal subjects.It has been shown that the time relations of the responses to these two hormones are remarkably simi- lar, but that there may be considerable individual variations in responsiveness to either cortisone or A.C.T.H., or both.The eosinopenic response to various A.C.T.H. prepara- tions and to stress have also been compared, and throughout these studies the differences of individual responsiveness of our subjects have been maintained.Three patients with panhypopituitarism showed an eosinopenic response to oral cortisone which was exaggerated and prolonged.In spite of the many factors which may influence eosinopenic responsiveness it is suggested that a study of the eosinopenic response to 50 mg. of oral cortisone, added to the already well-established A.C.T.H. response test, might provide a useful guide to therapy with these hormones in the indi- vidual concerned, and might possibly give some indication of the state of activity of the individual's own pituitaryadrenal mechanism.
MENTAL DEFICIENCY AND DELINQUENCY
Authors: OLGA BRIDGMAN
Journal: JAMA (1913)

Just now, while the vice question is being considered from so many sides and various causes for sexual immorality are being studied, with the hope of improving conditions if possible, it will not be amiss to direct attention to one group of young girls who for some reason have been unable to cope with the conditions confronting them and so have gone wrong. Special stress is being laid on such causes as inadequate wages, and natural immoral tendencies on the part of the girls themselves as being important contributory factors. The State Training School for Girls at Geneva has at present a population of approximately four hundred children, the vast majority of whom have been committed for sexual immorality, and of whom, on admission, nearly 60 per cent, are suffering from a venereal disease.  Why has all this immorality occurred? At present it is of course impossible to answer this
Abstract 520: Functional genomic screens identify microRNA regulators of the oncogenic fusion transcription factor EWS-FLI1
Authors: Suntae Kim, Patrick J. Grohar, Carleen Klumpp, Ashish Lal, Scott E. Martin, Lee J. Helman, Natasha J. Caplen
Journal: Cancer Research (2014)

Abstract Ewing sarcoma (ES) is a highly aggressive malignant pediatric cancer of the bone and soft tissue with a poor prognosis. The genetic hallmark of ES is the t(11:22)(q24:q12) translocation that generates a fusion transcript containing the 5’ end of EWSR1 and the 3’ end of FLI1 referred to as EWS-FLI1. This fusion generates an oncogenic transcription factor, EWS-FLI1 that is responsible for malignant transformation and is necessary for ES cell survival. To enhance our understanding of the molecular mechanisms underlying ES, with the long-term aim of enhanced treatment for this cancer, we are applying RNAi functional genomic approaches. MicroRNAs (miRNAs) are critical regulators of gene expression. There is evidence that many transcription factors and miRNAs act in concert to regulate gene expression. To identify miRNAs that directly or indirectly modulate EWS-FLI1 activity we conducted parallel screens of mimics or inhibitors of the human miRome using a cell-based reporter assay. The reporter assay consists of two isogenic reporter cell lines generated in the EWS-FLI1 expressing TC32 cell line. One line harbors a luciferase reporter driven by the promoter of an established EWS-FLI1 target NR0B1, while the second line expresses luciferase from a constitutive CMV promoter. A comparison of the effects of a miRNA on these two reporter constructs can identify proteins that specifically modulate EWS-FLI1 activity. We first identified those miRNAs for which a differential effect was seen when the NR0B1- and CMV-luciferase signals were compared and prioritized those where the mimic and inhibitor corresponding to a specific miRNA exhibited opposite effects. Twenty-eight miRNAs were identified, including miR-145, an established regulator of EWS-FLI1. The screen also identified miRNAs that have not been linked to EWS biology. One such candidate is miR-200b, a known regulator of epithelial-mesenchymal transition and tumor progression. We have confirmed that biotinylated-miR-200b captures the EWS-FLI1 mRNA when transfected into TC32 and ∼300 other mRNAs that includes EWS-FLI1 target genes. This functional genomic approach gives us an opportunity to investigate the co-regulatory activity of an oncogenic transcription factor and miRNAs in a systematic fashion that could be extended to investigate the co-regulation of other transcription factors and miRNAs. Citation Format: Suntae Kim, Patrick J. Grohar, Carleen Klumpp, Ashish Lal, Scott E. Martin, Lee J. Helman, Natasha J. Caplen. Functional genomic screens identify microRNA regulators of the oncogenic fusion transcription factor EWS-FLI1. [abstract]. In: Proceedings of the 105th Annual Meeting of the American Association for Cancer Research; 2014 Apr 5-9; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2014;74(19 Suppl):Abstract nr 520. doi:10.1158/1538-7445.AM2014-520
GENITAL GONORRHEA IN EARLY CHILDHOOD
Authors: C. W. Mason
Journal: JAMA (1918)

<h3>To the Editor:</h3> —The article by Dr. Haines on "Acquired Genital Syphilis in the Infant" (The Journal, Feb. 9, 1918, p. 370) prompts me to report five cases of gonorrhea in early childhood that came to my notice at my former dispensary clinic in Chiengmai, Siam. I believe that this is a fairly rare condition anywhere. All five cases were in girls ranging from 2 to 7 years of age. A Chino-Lao girl, aged 2 years, complained of painful micturition. I suspected urinary calculus of the bladder, as this is very common; but examination showed the whole vulva smeared with a thin, creamy pus, a microscopic examination of which disclosed the gonococci in large numbers. I then questioned the father, who with practically no hesitation said that he had gonorrhea and that he had expressed some of the pus from his penis onto his finger and then deliberately rubbed it
A Phase II Trial of the Multitargeted Tyrosine Kinase Inhibitor Lenvatinib (E7080) in Advanced Medullary Thyroid Cancer
Authors: Martin Schlumberger, Barbara Jarzab, Maria E. Cabanillas, Bruce Robinson, Furio Pacini, Douglas W. Ball, Judith McCaffrey, Kate Newbold, Roger Allison, Renato G. Martins, Lisa F. Licitra, Manisha H. Shah, Donald Bodenner, Rossella Elisei, Lynn Burmeister, Yasuhiro Funahashi, Min Ren, James P. O'Brien, Steven I. Sherman
Journal: Clinical Cancer Research (2015)

Abstract Purpose: Positive results of phase I studies evaluating lenvatinib in solid tumors, including thyroid cancer, prompted a phase II trial in advanced medullary thyroid carcinoma (MTC). Experimental Design: Fifty-nine patients with unresectable progressive MTC per Response Evaluation Criteria In Solid Tumors (RECIST) v1.0 within the prior 12 months received lenvatinib (24-mg daily, 28-day cycles) until disease progression, unmanageable toxicity, withdrawal, or death. Prior anti-VEGFR therapy was permitted. The primary endpoint was objective response rate (ORR) by RECIST v1.0 and independent imaging review. Results: Lenvatinib ORR was 36% [95% confidence interval (CI), 24%–49%]; all partial responses. ORR was comparable between patients with (35%) or without (36%) prior anti-VEGFR therapy. Disease control rate (DCR) was 80% (95% CI, 67%–89%); 44% had stable disease. Among responders, median time to response (TTR) was 3.5 months (95% CI, 1.9–3.7). Median progression-free survival (PFS) was 9.0 months (95% CI, 7.0–not evaluable). Common toxicity criteria grade 3/4 treatment-emergent adverse events included diarrhea (14%), hypertension (7%), decreased appetite (7%), fatigue, dysphagia, and increased alanine aminotransferase levels (5% each). Ret proto-oncogene status did not correlate with outcomes. Low baseline levels of angiopoietin-2, hepatocyte growth factor, and IL8 were associated with tumor reduction and prolonged PFS. High baseline levels of VEGF, soluble VEGFR3, and platelet-derived growth factor BB, and low baseline levels of soluble Tie-2, were associated with tumor reduction. Conclusions: Lenvatinib had a high ORR, high DCR, and a short TTR in patients with documented progressive MTC. Toxicities were managed with dose modifications and medications. Clin Cancer Res; 22(1); 44–53. ©2015 AACR.
HER2/Neu (ErbB2) Signaling to Rac1-Pak1 Is Temporally and Spatially Modulated by Transforming Growth Factor β
Authors: Shizhen Emily Wang, Incheol Shin, Frederick Y. Wu, David B. Friedman, Carlos L. Arteaga
Journal: Cancer Research (2006)

Abstract In HER2 (ErbB2)-overexpressing cells, transforming growth factor β (TGF-β), via activation of phosphoinositide-3 kinase (PI3K), recruits actin and actinin to HER2, which then colocalizes with Vav2, activated Rac1, and Pak1 at cell protrusions. This results in prolonged Rac1 activation, enhanced motility and invasiveness, Bad phosphorylation, uncoupling of Bad/Bcl-2, and enhanced cell survival. The recruitment of the HER2/Vav2/Rac1/Pak1/actin/actinin complex to lamellipodia was abrogated by actinin siRNAs, dominant-negative (dn) p85, gefitinib, and dn-Rac1 or dn-Pak1, suggesting that the reciprocal interplay of PI3K, HER2 kinase, and Rac GTPases with the actin cytoskeleton is necessary for TGF-β action in oncogene-overexpressing cells. Thus, by recruiting the actin skeleton, TGF-β “cross-links” this signaling complex at cell lamellipodia; this prolongs Rac1 activation and increases metastatic properties and survival of HER2-overexpressing cells. (Cancer Res 2006; 66(19): 9591-600)
Functional characterization of alloreactive T cells identifies CD25 and CD71 as optimal targets for a clinically applicable allodepletion strategy
Authors: Sujith Samarasinghe, Christoph Mancao, Martin Pule, Niga Nawroly, Helen Karlsson, Jennifer Brewin, Peter Openshaw, H. Bobby Gaspar, Paul Veys, Persis J. Amrolia
Journal: Blood (2009)
Alternatives to Metronidazole
Authors: Anthony L. Komaroff
Journal: JAMA (1976)

To the Editor.—  The recent warning in The Medical Letter  1 regarding the mutagenicity and possible carcinogenicity of metronidazole (Flagyl) raises the question of whether there is an alternative treatment of equal efficacy that is not equally suspect.  The pharmacologic treatment options seem to include orally administered nitroimidazole drugs other than metronidazole, or topical agents available in vaginal-tablet or suppository form, such as furazolidone and nifuroxime (components of Tricofuron). None of the other nitroimidazoles are currently available in the United States, although tinidazole (Fasigyn) will apparently soon be released. Tinidazole 2 and nimorazole are reported to have a better than 90% cure rate. However, the mutagenicity of nimorazole was demonstrated in the same study that implicated metronidazole, 3 and subsequent research by the same group has apparently also demonstrated the mutagenic potential of tinidazole (C. E. Voogd, unpublished data).  The efficacy of topically applied furazolidone, alone or in combination with
ACIDOSIS AS A COMPLICATION AFTER SURGICAL OPERATIONS
Authors: W. B. RUSS
Journal: JAMA (1913)

No length of training in surgical technic, no amount of experience in the operating-room, can make a competent surgeon of any man who is poorly equipped in the theory and practice of general medicine. The practitioner of surgery who loses interest in the problems of internal medicine becomes in time but little better than an overrated and overpaid mechanic plus a deficient surgical judgment and minus a surgical conscience; yet many of our surgeons of great note and most of the lesser lights struggling for recognition actually boast of their ignorance of, and lack of interest in, any branch of medicine outside the immediate scope of their special work. It is small wonder, then, that the men engaged in other lines of work, particularly the neurologists, complain that most of the so-called neurasthenic patients they are called on to treat present abdomens decorated with scars marking the sites of operations
Mandatory HPV Vaccination
Authors: Melissa B. Gilkey, Noel T. Brewer
Journal: JAMA (2012)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Psoriatic Arthritis: A Comparative Radiographic Study of Rheumatoid Arthritis and Arthritis Associated with Psoriasis
Authors: V. Wright
Journal: Annals of the Rheumatic Diseases (1961)

Attention was focused on the association of psoriasis and arthritis by Alibert (1822), and the first detailed examination of the relation between the two was that of Bourdillon (1888).Since then there has been much interest in and argument about psoriatic arthritis.Definitions of the condition have been various: an arthritis confined to the distal interphalangeal joints associated with psoriasis (Bauer, Bennett, and Zeller, 1941), an atypical arthritis associated with atypical psoriasis (Dawson, 1937), and a form of atrophic arthritis associated with psoriasis exhibiting a reasonable amount of synchronous activity as evidenced by remissions and relapses in arthritis and cutaneous manifesta- tions (Epstein, 1939; Jeghers and Robinson, 1937; Lane and Crawford, 1937).Other authors have denied its existence as a separate entity, feeling that it represented the coincidence of two common diseases, psoriasis and rheumatoid arthritis (Brocq, 1910; Gribble, 1955; Margolis, 1941).Recently, workers with the Rose-Waaler differential agglutina- tion test (D.A.T.), which is positive in about 80 per cent. of patients with rheumatoid arthritis (Greenbury, Hill, Spalding Smith, and Good, 1956;
1412 INTERFERON-FREE TREATMENT WITH A COMBINATION OF MERICITABINE AND DANOPREVIR/R WITH OR WITHOUT RIBAVIRIN IN TREATMENT-NAIVE HCV GENOTYPE 1-INFECTED PATIENTS
Authors: E.J. Gane, P. Pockros, S. Zeuzem, P. Marcellin, A. Shikhman, C. Bernaards, E.S. Yetzer, N. Shulman, X. Tong, I. Najera, A. Bertasso, J. Hammond, S. Stancic
Journal: Journal of Hepatology (2012)
Nitric Oxide for Preemies — Not So Fast
Authors: Richard J. Martin
Journal: New England Journal of Medicine (2003)

The past three decades have seen the emergence of neonatology as a vibrant subspecialty of pediatrics, highlighted by advances in the management of the respiratory distress syndrome in preterm infants. It is now widely accepted that surfactant deficiency is the biologic basis for neonatal respiratory distress syndrome and that a combination of antenatal corticosteroids, postnatal surfactant therapy, and effective ventilatory assistance is key to successful management. Historically, pulmonary ischemia was thought to be an underlying physiological mechanism for neonatal respiratory distress syndrome; it is now clear that residual fetal pulmonary hypertension, with resultant shunting of deoxygenated blood away from the . . .
Neonatal meningitis treated with trimethoprim and sulphamethoxazole.
Authors: R. N. Morzaria, I. G. Walton, D. Pickering
Journal: BMJ (1969)

Collaborative risk assessment and management have been recommended in health policy for over a decade. We consider the nature and need for collaborative risk assessment and management between patients and clinicians in secure and forensic mental health settings in the context of shared decision making and personalised care in the UK. We examine the extent to which policy and recent initiatives have influenced the embedding of such practice in services through consideration of the evidence provided by research and the Commissioning for Quality and Innovation framework, and conclude that there is a need for further improvement.
479 THE RELATIONSHIP BETWEEN SEXUAL DYSFUNCTION, DEPRESSION AND QUALITY OF LIFE AMONG FEMALE BEFORE AND AFTER LIVER TRANSPLANTATION
Authors: A. Masier, M. Senzolo, T. Fanelli, P. Bo, A. Tasinato, U. Cillo, A. Salonia, G.C. Sturniolo, P. Burra
Journal: Journal of Hepatology (2009)
Imagery in multi-modal object learning
Authors: Martin Jüttner, Ingo Rentschler
Journal: Behavioral and Brain Sciences (2002)

Spatial objects may not only be perceived visually but also by touch. We report recent experiments investigating to what extent prior object knowledge acquired in either the haptic or visual sensory modality transfers to a subsequent visual learning task. Results indicate that even mental object representations learnt in one sensory modality may attain a multi-modal quality. These findings seem incompatible with picture-based reasoning schemas but leave open the possibility of modality-specific reasoning mechanisms.