GLYCINE AND SODIUM GLUCURONATE IN THE MANAGEMENT OF CONVULSIONS DUE TO HYDRAZIDES
Authors: S KATZ, A GIMBLE, G MCCORMICK, B PRESCOTT
Journal: Annals of Internal Medicine (1956)

Case Reports1 March 1956GLYCINE AND SODIUM GLUCURONATE IN THE MANAGEMENT OF CONVULSIONS DUE TO HYDRAZIDESSOL KATZ, M.D., F.A.C.P., ABE GIMBLE, M.D., GEORGES MCCORMICK, M.D., BENJAMIN PRESCOTT, Ph.D.SOL KATZ, M.D., F.A.C.P.Search for more papers by this author, ABE GIMBLE, M.D.Search for more papers by this author, GEORGES MCCORMICK, M.D.Search for more papers by this author, BENJAMIN PRESCOTT, Ph.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-44-3-576 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptIsoniazid and Salizid (Compound 1595,† also a hydrazide derivative of isonicotinic acid) are two of the most effective and least toxic antituberculous drugs presently available. Although significant side effects are infrequent from the use of these drugs, peripheral neuritis and convulsions constitute toxic reactions sufficiently severe to require that therapy be discontinued or dosage reduced.Isoniazid, in therapeutic doses, may produce convulsions which resemble grand mal epilepsy.1This problem may occur in patients without a previous history of epilepsy. The hazards of isoniazid therapy in epileptics have been reported by Fetterhoff,2who cited a case of status epilepticus precipitated by...Bibliography1. ReillyKilliamJennyMarshallTausigApterPfeiffer RHMSEHWHTNSCC: Convulsant effects of isoniazid, J. A. M. A. 152: 1317, 1953. CrossrefMedlineGoogle Scholar2. FetterhoffHolmesMartin KICXGE: Hazards of isoniazid therapy in epileptics, Am. Rev. Tuberc. 66: 501, 1952. MedlineGoogle Scholar3. KatzMcCormickdeLeonGruverStantonBakirMarshall SGARJFE: The intermittent use of combined streptomycin and isoniazid in pulmonary tuberculosis, Transactions of 13th Conference on Chemotherapy of Tuberculosis, Veterans Administration, Army and Navy, St. Louis, February 9-12, 1954, p. 355. Google Scholar4. JenneySmithPfeiffer EHRPCC: Pyridoxine as an antidote to semicarbazide seizures, Federation Proc. 12: 333, 1953. Google Scholar5. PrescottKauffmannJames BGWD: A means of increasing the tolerated dose of isoniazid in mice, Proc. Soc. Exper. Biol. and Med. 86: 682, 1954. CrossrefMedlineGoogle Scholar6. OlsonPrescottPiggottJamesPilgrenKauffmannCline BJBWRWDEYGWL: Studies on prolonged treatment of experimental tuberculosis in mice with large doses of isoniazid, presented at the Society for Experimental Biology and Medicine, District of Columbia Section, February 3, 1955. Google Scholar7. GompertzBrown JLC: Results of treatment of pulmonary tuberculosis with D-glucuronolactone isonicotinyl hydrazone, Transactions of 13th Conference on Chemotherapy of Tuberculosis, Veterans Administration, Army and Navy, St. Louis, February 9-12, 1954, p. 366. Google Scholar8. BronetHalpernMarcheMallet GBNJJ: D'un nouvel agent chemiotherapique de la tuberculose (isonicotyl-hydrazone de la glycuronolactone), Presse méd. 61: 863, 1953. MedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: *Received for publication July 27, 1955.From the Pulmonary Disease Division, District of Columbia General Hospital (formerly Gallinger Municipal Hospital); Department of Medicine, Georgetown University School of Medicine, and George Washington University School of Medicine, Washington, D. C., and U. S. Department of Health, Education, and Welfare, Public Health Service, National Institutes of Health, National Microbiological Institute, Bethesda, Maryland.†Supplied by Dr. George Mast, Nepera Chemical Company, Yonkers, N. Y. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byPhysiologische Chemie der Lebensvorgänge und OrganeBiochemie des Isoniazids 1 March 1956Volume 44, Issue 3Page: 576-578KeywordsConvulsionsDrugsEpilepsyGlycineHospital medicineIsoniazidMedical servicesPulmonary diseasesSodiumStatus epilepticus ePublished: 1 December 2008 Issue Published: 1 March 1956 PDF downloadLoading ...