THE RED CELL INDICES IN THE DIAGNOSIS OF IRON-DEFICIENCY ANEMIA
Authors: E BEUTLER
Journal: Annals of Internal Medicine (1959)

Article1 February 1959THE RED CELL INDICES IN THE DIAGNOSIS OF IRON-DEFICIENCY ANEMIAERNEST BEUTLER, M.D.ERNEST BEUTLER, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-50-2-313 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptIt has been recognized for many years that patients with hypochromic microcytic anemia usually respond to iron therapy.1Conversely, it has usually been assumed that iron deficiency always causes a hypochromic microcytic anemia. Thus, it has been stated authoritatively that "hypochromic microcytic anemia . . . is the only type of anemia in which such treatment [iron] is clearly effective."2More recently, it has been found that iron-sensitive anemias are also characterized by the absence of stainable iron in the sternal marrow,3and often by reduction of the plasma iron concentration in association with an increase in the iron-binding capacity...Bibliography1. HeathPatek CWAJ: The anemia of iron deficiency, Medicine 16: 267-350, 1937. CrossrefGoogle Scholar2. Wintrobe MM: Clinical hematology, 4th Ed., 1956, Lea and Febiger, Philadelphia, p. 733. Google Scholar3. RathFinch CGCA: Sternal marrow hemosiderosis, J. Lab. and Clin. Med. 33: 81-86, 1948. MedlineGoogle Scholar4. Laurell CB: Studies on the transportation of metabolism of iron in the body, Acta physiol. Scandinav. 14: Supp. 46, 1947. Google Scholar5. BeutlerRobsonButtenwieser EMJE: A comparison of the plasma iron, iron-binding capacity, sternal marrow iron and other methods in the clinical evaluation of iron stores, Ann. Int. Med. 48: 60-82, 1958. LinkGoogle Scholar6. RobsonMarks MJEK: Unpublished data. Google Scholar7. McGovernJonesSteinberg JJARAG: The hematocrit of capillary blood, New England J. Med. 253: 308-312, 1955. CrossrefMedlineGoogle Scholar8. Wintrobe MM: Clinical hematology, 4th Ed., 1956, Lea and Febiger, Philadelphia, pp. 392-393. Google Scholar9. Moroney MJ: Facts from figures, 1951, Penguin Books, Harmondsworth, Middlesex, Chapter 16. Google Scholar10. Wintrobe MM: Anemia—classification and treatment on the basis of differences in the average volume and hemoglobin content of the red corpuscles, Arch. Int. Med. 54: 256-280, 1934. CrossrefGoogle Scholar11. Stevens AR: The mechanism and treatment of iron deficiency anemia, Arch. Int. Med. 96: 550-554, 1956. CrossrefGoogle Scholar12. HeilmeyerPlötner LK: Das Serumeisen und die Eisenmangelkrankheit (Pathogenese, Symptomatologie und Therapie), 1937, Verlag von Gustav Fischer, Jena. Google Scholar13. Beutler E: Iron enzymes in iron deficiency. I. Cytochrome C, Am. J. M. Sc. 234: 517-527, 1957. CrossrefMedlineGoogle Scholar14. Walters OS: Normal erythrocyte, hemoglobin and packed cell volume standards in young men, J. Lab. and Clin. Med. 19: 851-864, 1934. Google Scholar15. FreedmanMirsky AMAJ: Estimation of red cell count from hematocrit, Am. J. Clin. Path. 16: 104-109, 1946. CrossrefGoogle Scholar16. Johnson J: Microhematocrit versus erythrocyte count. I. Correlation of microhematocrit, erythrocyte count and hemoglobin. II. Suggested normal range for erythrocytes, hemoglobin and packed cell volume for southern Ohio, Am. J. M. Technol. 23: 199-215, 1957. MedlineGoogle Scholar17. Wintrobe MM: Clinical hematology, 3rd Ed., 1951, Lea and Febiger, Philadelphia, p. 102. Google Scholar18. Osgood EE: Hemoglobin, color index, saturation index, volume index standards; redeterminations based on findings in 137 healthy young men, Arch. Int. Med. 37: 685-705, 1926. CrossrefGoogle Scholar19. BelkCurtisWilson WPEMK: Erythrocyte counts, hemoglobin and erythrocyte volume in normal young men and women residing in the eastern United States, Am. J. Clin. Path. 6: 487-496, 1936. CrossrefGoogle Scholar20. HamreAu CJMH: Hematologic values for normal healthy men 16 to 25 years of age, J. Lab. and Clin. Med. 27: 1231-1244, 1942. Google Scholar21. LewisOhlsenCederquistDonelson GKMADEG: The corpuscular constants of college women of the north central states, J. Lab. and Clin. Med. 32: 419-422, 1947. MedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: ERNEST BEUTLER, M.D.Affiliations: Chicago, Illinois*Received for publication May 23, 1958.From the Argonne Cancer Research Hospital, USAEC, and The Department of Medicine, The University of Chicago.Requests for reprints should be addressed to Ernest Beutler, M.D., Assistant Professor of Medicine, The University of Chicago, Chicago 37, Illinois. 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