tbuckley/cabot-search huggingface dataset:
Abstract 11590: Different Cardiac Allograft Vasculopathy Progression is Observed Among Three Vessels After Heart Transplantation
Authors: Yasuhiro Ichibori, Jun-ichi Kotani, Yasumasa Tsukamoto, Tomohito Ohtani, Osamu Yamaguchi, Koichi Tachibana, Koichi Toda, Norihide Fukushima, Yoshiki Sawa, Yasushi Sakata
Journal: Circulation (2014)

Introduction: Cardiac allograft vasculopathy (CAV) after heart transplantation (HTx) has been considered to diffuse similarly among the coronaries (CAs). However, individual plaque formation more than 5 years after HTx is unclear. Optical coherence tomography (OCT) provides higher resolution and ability of tissue characterization than angiography.

Hypothesis: CAV progression may differ in the early and late periods after HTx.

Methods: We studied 97 consecutive CAs from 39 patients (32 male, 41±14 yrs.) who received multivessel study using OCT at annual catheterization (f/u). Data were divided into 2 groups according to the period from HTx to f/u, and compared the spatial differences among CAs (early; 1-4 yrs., n=56 [LAD 22, LCX 16, RCA 18] and late; 5-17 yrs., n=41 [LAD 15, LCX 13, RCA 13]). Plaque was classified as fibroatheroma (cap thickness≤70μm=TCFA), lipid (arc>180°=large) and calcium. Macrophage, TCFA, large lipid and thrombi were considered as vulnerable. For longitudinal plaque progression we used length of IEM undamaged by plaque, expressed by % per investigated length (intact media length index).

Results: Media was most intact in LCX in both groups. However, all intact media decreased similarly (figure A). Maximum intimal thickness was smallest in LCX in both early (0.9±0.4 for LAD, 0.6±0.3 for LCX, 0.9±0.4mm for RCA; P=0.06) and late (1.1±0.3, 0.6±0.2, 0.8±0.3mm; respectively: P=0.01). Spatial plaque formations among the CAs in individual patients were similar in early; however, each vessel formed plaque independently in late. Throughout the analysis, LCX presented small atherosclerotic change while vulnerable burden was detected in major CAs, such as LAD and RCA, in late (figure B).

Conclusions: After 5 yrs. from HTx, CAV progresses differently among the coronary tree with individual plaque formation and maturing, ie, vulnerable change.

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The Effects of Thyroxine on Nucleic Acid and Protein Metabolism in Mouse Thyrotropic Pituitary Tumors
Authors: F. L. Moolten, J. F. Scott
Journal: Cancer Research (1963)

Summary  The effects of thyroxine on the incorporation of glycine-1-C14 into ribonucleic acid (RNA), deoxyribonucleic acid (DNA), acid-soluble purines, and protein were compared in nine thyroxine-inhibitable (“dependent”) and twelve autonomous thyrotropic pituitary tumors in LAF1 mice.  Orotic acid-6-C14 was given to all mice prior to thyroxine (or control) treatment, to provide, in the case of RNA and DNA, an index of the effect of thyroxine less variable than glycine incorporation alone; viz., the ratio incorporation of glycine into purines/incorporation of orotic acid into pyrimidines (RSA purines/RSA pyrimidines).  In dependent tumors, thyroxine treatment was associated with a significant reduction in this ratio—56 per cent in the case of RNA and 35 per cent in the case of DNA. This apparent inhibition of nucleic acid synthesis may reflect at least in part an inhibition of purine synthesis, since thyroxine treatment was associated with a 51 per cent reduction in the incorporation of glycine into acid-soluble purines in one of two subpassages of the dependent tumor strain studied. Incorporation of glycine into protein was not demonstrably affected in these short-term experiments.  In autonomous tumors, thyroxine did not demonstrably affect RNA, DNA, purine, or protein synthesis, as measured by incorporation of glycine, or by the ratio RSA purines/RSA pyrimidines.  It appears that the acquisition of autonomy by mouse thyrotropic tumors is associated with a loss of susceptibility of nucleic acid synthesis to inhibition by thyroxine.
Known and potential new risk factors for skin cancer in European populations: a multicentre case-control study
Authors: E. de Vries, M. Trakatelli, D. Kalabalikis, L. Ferrandiz, A. Ruiz-de-Casas, D. Moreno-Ramirez, D. Sotiriadis, D. Ioannides, S. Aquilina, C. Apap, R. Micallef, L. Scerri, M. Ulrich, S. Pitkänen, O. Saksela, E. Altsitsiadis, B. Hinrichs, C. Magnoni, C. Fiorentini, S. Majewski, A. Ranki, E. Stockfleth, C. Proby
Journal: British Journal of Dermatology (2012)

Background During recent years numerous studies have suggested that personal and environmental factors might influence cancer development. Objectives To investigate environmental and personal characteristics associated with skin cancer risk. Methods A multicentre hospital‐based case–control study was performed in Finland, Germany, Greece, Italy, Malta, Poland, Scotland and Spain, including 409 patients with squamous cell carcinoma (SCC), 602 with basal cell carcinoma (BCC) and 360 with cutaneous malignant melanoma (CMM) and 1550 control persons. Exposures were assessed by questionnaires that were partly self‐administered, partly completed by dermatologists. Unconditional logistic regression modelling was used to assess associations including the influence of certain drugs and food items on skin cancer risk. Results The usual associations were observed for sun exposure and pigmentation characteristics, with chronic sun exposure being most strongly associated with SCC risk, and naevi and atypical naevi with CMM risk. Use of ciprofloxacin was associated with a decreased risk of BCC [odds ratio (OR) 0·33] and use of thiazide diuretics was associated with an increased risk of SCC (OR 1·66). Ciprofloxacin was also associated with SCC (OR 0·34) and thiazines with BCC (OR 2·04), but these associations lost significance after correction for multiple testing. Consumption of pomegranate, rich in antioxidants, was associated with decreased BCC and SCC risk, also after correcting for multiple testing. Recent experience of stressful events was associated with increased risk, particularly of CMM. Conclusions In this large case–control study from across Europe the expected associations were observed for known risk factors. Some new potential protective factors and potential risk factors were identified for consumption of certain food items, medication use and stress, which deserve further investigation in future studies.
Ongoing Consequences of Disparities in Breast Cancer Surgery
Authors: Lisa A. Newman
Journal: JAMA Surgery (2015)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Surgery HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Surgery journal
Variation in allergen content in sublingual allergen immunotherapy with house dust mites
Authors: F. Moreno Benítez, M. Espinazo Romeu, A. Letrán Camacho, S. Mas, F. J. García‐Cózar, A. I. Tabar
Journal: Allergy (2015)

Background Allergen immunotherapy is a treatment modality which can be applied using different vaccines. The aim of this study was to quantify and compare the allergen content of different house dust mites (HDM)' sublingual treatments and to review the evidence on their efficacy. Methods Five sublingual allergen immunotherapy (SLIT) products were ordered and purchased at an ordinary pharmacy and masked for blinding before the study was started. Detection of Dermatophagoides pteronyssinus and Dermatophagoides farinae allergens Der p 1, Der f 1, Der p 2 and Der f 2 was carried out by immunoblotting and fluorescent multiplex. A literature search for meta-analyses and systematic reviews that included SLIT-HDM products was performed. Results Der p 1 concentrations ranged from 0.6 to 14.5 μg/ml; similar figures were found for Der f 1 that ranged from 0.2 to 12.4 μg/ml. Der p 2+ Der f 2 ranged from 0.2 to 1.5 μg/ml. Data on efficacy are scarce for most of the five products. Conclusions Substantial variations regarding allergen content were found among these five SLIT-HDM products. Therefore, it can be necessary to guarantee the quality of the SLIT-HDM products and to demonstrate their effectiveness before they are marketed. It seems necessary, for the moment, to take into account these characteristics of the products before prescribing.
Tangier disease is caused by mutations in the gene encoding ATP-binding cassette transporter 1
Authors: Stephan Rust, Marie Rosier, Harald Funke, José Real, Zahir Amoura, Jean-Charles Piette, Jean-Francois Deleuze, H. Bryan Brewer, Nicolas Duverger, Patrice Denèfle, Gerd Assmann
Journal: Nature Genetics (1999)
Lesson of the week: Benign sleep myoclonus in infancy mistaken for epilepsy
Authors: J. Egger
Journal: BMJ (2003)

Background: The naturally-occurring phytochemical tannic acid (TA) has anticancer properties. We have demonstrated that estrogen receptor-positive (ER<sup>+</sup>) breast cancer cells are more sensitive to effects of TA than triple-negative breast cancer cells and normal breast epithelial cells. In the present study, cells were grown on TA-crosslinked collagen beads. Growing cells remodel collagen and release TA, which affects attached cells. Materials and Methods: The ER<sup>+</sup> breast cancer cell line MCF7 and the normal breast epithelial cell line MCF10A were grown on TA-crosslinked collagen beads in roller bottles. Concentrations of TA in conditioned media were determined. Induced apoptosis was imaged and quantified. Caspase gene expression was calculated by real-time polymerase chain reaction (PCR). Results: Both cell lines attached and grew on TA-crosslinked collagen beads where they remodeled collagen and released TA into surrounding medium. Released TA induced caspase-mediated apoptosis. Conclusion: TA induced apoptosis in a concentration-dependent manner, with ER<sup>+</sup> MCF7 cells displaying more sensitivity to effects of TA.
Abstract ES8-1: Spatial and temporal evolution of breast cancer
Authors: Lucy Yates
Journal: Cancer Research (2015)

Abstract Cancers are ecosystems of genetically related clones, competing across space and time for limited resources. To understand the clonal structure of breast cancers we applied a combination of high depth targeted capture and whole genome sequencing to multiple samples from individual primary breast cancers and metastases. Our work has identified that the extent of subclonal diversification within the primary tumor varies considerably among patients and encompasses many spatial patterns, including local growth, intraductal dissemination and clonal intermixture. Landmarks of disease progression, such as acquiring invasive or metastatic potential are frequently associated with the emergence of distinct driver events and sometimes arise within detectable subclones of antecedent lesions, suggesting that subclonal mutations in the primary tumor could be relevant if actionable. The impact of structural variation on the breast cancer driver landscape is relatively understudied, but our work indicates that structural variation frequently makes a major contribution to the somatic mutational landscape late in disease evolution. Thus, the interplay of mutation, growth and competition drives clonal structures of breast cancer that are complex, variable across patients and clinically relevant. Citation Format: Lucy Yates. Spatial and temporal evolution of breast cancer [abstract]. In: Proceedings of the Thirty-Seventh Annual CTRC-AACR San Antonio Breast Cancer Symposium: 2014 Dec 9-13; San Antonio, TX. Philadelphia (PA): AACR; Cancer Res 2015;75(9 Suppl):Abstract nr ES8-1.
Second-generation deinstitutionalization, II: The impact of Brewster v. Dukakis on correlates of community and hospital utilization
Authors: J L Geller, W H Fisher, L J Simon, J L Wirth-Cauchon
Journal: American Journal of Psychiatry (1990)

On the basis of the principle that patients have the right to be treated in the least restrictive setting appropriate to their needs, all 368 patients at Northampton State Hospital (Massachusetts) were discharged over a 10-year period. Three-quarters were discharged to community settings. Half of the patients were never rehospitalized, but many others continued to display patterns of recidivism. On the assumption that socially dysfunctional behavior would improve after discharge, the funded community system emphasized assessments, residential placements, and crisis intervention and deemphasized treatment. The findings raise many questions about the efficacy and wisdom of attempting to serve an entire state hospital population in the community.
Genes Help Unravel Marfan Pathology, Point Way to Potential New Therapies
Authors: Bridget M Kuehn
Journal: JAMA (2005)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
ABC of antithrombotic therapy: Valvar heart disease and prosthetic heart valves
Authors: I. Goldsmith
Journal: BMJ (2002)

Thromboembolism and anticoagulant related bleeding are major life threatening complications in patients with valvar heart disease and those with prosthetic heart valves. In these patients effective and safe antithrombotic therapy is indicated to reduce the risks of thromboembolism while keeping bleeding complications to a minimum.

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Valve thrombosis of a bileaflet prosthetic mitral valve

Risk factors that increase the incidence of systemic embolism must be considered when defining the need for starting antithrombotic therapy in patients with cardiac valvar disease and prosthetic heart valves. These factors include age, smoking, hypertension, diabetes, hyperlipidaemia, type and severity of valve lesion, presence of atrial fibrillation, heart failure or low cardiac output, size of the left atrium (over 50 mm on echocardiography), previous thromboembolism, and abnormalities of the coagulation system including hepatic failure.

Secondly, the type, number, and location of prostheses implanted must be considered. For example, mechanical prostheses are more thrombogenic than bioprostheses or homografts, and hence patients with mechanical valves require lifelong anticoagulant therapy. However, the intensity of treatment varies according to the type of mechanical prosthesis implanted. First generation mechanical valves, namely the Starr-Edwards caged ball valve and Bjork-Shiley standard valves, have a high thromboembolic risk; single tilting disc valves have an intermediate thromboembolic risk; and the newer (second and third generation) bileaflet valves have low thromboembolic risks.

#### Considerations for antithrombotic therapy in patients with valve disease

In patients with a bioprosthesis in sinus rhythm, antithrombotic therapy with an …

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Efficacy of psoralen plus ultraviolet A therapy vs. biologics in moderate to severe chronic plaque psoriasis: retrospective data analysis of a patient registry
Authors: M. Inzinger, B. Heschl, W. Weger, A. Hofer, F.J. Legat, A. Gruber-Wackernagel, H. Tilz, W. Salmhofer, F. Quehenberger, P. Wolf
Journal: British Journal of Dermatology (2011)

Few studies have directly compared the clinical efficacy of psoralen plus ultraviolet A (PUVA) vs. biologics in the treatment of psoriasis.To compare the clinical efficacy of PUVA and biologic therapies for psoriasis under daily life conditions.Data from a psoriasis registry (http://www.psoriasis-therapieregister.at) of 172 adult patients with moderate to severe chronic plaque psoriasis treated between 2003 and 2010 were analysed retrospectively. These patients had received oral PUVA [118 treatment courses including 5-methoxypsoralen (5-MOP; n = 32) and 8-methoxypsoralen (8-MOP; n = 86)] and/or biologic agents [130 treatment courses including adalimumab (n = 18), alefacept (n = 32), efalizumab (n = 17), etanercept (n = 38), infliximab (n = 7) and ustekinumab (n = 18)]. Treatment responses were analysed in terms of Psoriasis Area and Severity Index (PASI) improvement, including complete remission (CR) and reduction of PASI by at least 90% (PASI 90) or 75% (PASI 75), at treatment completion for PUVA (median time 10·3 and 9·2 weeks, for 8-MOP and 5-MOP, respectively) and at week 12 for biologics.Intention-to-treat-as observed CR, PASI 90 and PASI 75 rate was 22%, 69% and 86% for PUVA compared with 6%, 22% and 56% for adalimumab (P = 0·0034 by adapted Wilcoxon test), 3%, 3% and 25% for alefacept (P = 0·000000002), 6%, 6% and 59% for efalizumab (P = 0·000053), 6%, 29% and 39% for etanercept (P = 0·0000086), 29%, 71% and 100% for infliximab (P = 0·36) and 6%, 39% and 67% for ustekinumab (P = 0·028). When applying a more conservative post-hoc modified worst-case scenario analysis, with CR of 15%, PASI 90 of 58% and PASI 75 of 69%, PUVA was superior only to alefacept (P = 0·000013), efalizumab (P = 0·015) and etanercept (P = 0·0037). There were no statistically significant differences in PASI reduction rates between PUVA and infliximab.Retrospective analysis of registry data revealed that the primary efficacy of PUVA was superior to that of certain biologics. Prospective head-to-head studies of PUVA and biologics are warranted to confirm these observations.
Abstract 1573: TUSC4 functions as tumor suppressor by regulating BRCA1 stability and functions
Authors: Yang Peng, Shiaw-Yih Lin
Journal: Cancer Research (2014)

Abstract Expression of the BRCA1 tumor suppressor is frequently lost in breast cancer and associated with aggressive phenotypes through as yet undetermined mechanisms. In this study, we demonstrated that the tumor suppressor TUSC4 (Tumor Suppressor Candicate 4) physically interacts with multiple DNA damage response proteins and prevent its degradation by E3 ligase ubqutination pathways. Knockdown of TUSC4 enhanced BRCA1 polyubiquitination, leading to BRCA1 protein degradation and significantly reduced the efficacy of homologous recombination repair. Notably, ectopic expression of TUSC4 effectively suppressed multiple breast cancer cells proliferation, invasion, and colony formation in vitro and tumor growth in vivo. Furthermore, TUSC4 knockdown was sufficient to transform normal mammary epithelial cells and enhance the sensitivity of cells to PARP inhibitors. Microarray analysis of TUSC4 knockdown also indicated critical changes and the global impact to cancer development. Therefore, TUSC4 acts as a bona fide tumor suppressor gene through the mechanism of regulating BRCA1 protein stability and function. Citation Format: Yang Peng, Shiaw-Yih Lin. TUSC4 functions as tumor suppressor by regulating BRCA1 stability and functions. [abstract]. In: Proceedings of the 105th Annual Meeting of the American Association for Cancer Research; 2014 Apr 5-9; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2014;74(19 Suppl):Abstract nr 1573. doi:10.1158/1538-7445.AM2014-1573
Abstract P454: The Predictors of Non-adherence of Regular Physical Activity After Coronary Revascularization
Authors: esra gucuk ipek, Burak Acar, Cengiz Burak, Fatih Bayraktar, Meryem Kara, Elif H Ozcan Cetin, Mehmet S Cetin, Umit Guray, Yesim Guray
Journal: Circulation (2014)

Background: Coronary heart disease the leading cause of mortality worldwide and regular physical activity is a comprehensive management strategy for these patients. We investigated the parameters that influence regular physical activity in patients with a history of coronary revascularization. Methods: We included outpatients who had a history of coronary revascularization at least 6 months prior to enrollment. A questionnaire was filled out with each patient to collect the data of engagement in regular physical activity, demographics, clinical characteristics, and dietary adherence. Results: We enrolled 202 consecutive outpatients (age 61.3±11.2 years, 73% males). The median duration after revascularization was 60 months. One hundred and 4 (51%) patients had previous percutaneous coronary intervention, 67 (33%) patients had coronary by-pass graft surgery, and 31 (15%) patients had both of the revascularization procedures. Of all, 46 (23%) patients were engaging in regular physical activity with a median of 2 days per week. Patients were classified into two subgroups according to their physical activity habits. There was no significant difference in age, comorbid conditions or revascularization type between subgroups. In the univariate regression analysis, absence of regular physical activity was associated with female gender, low education level, unemployment, low household income, implantation of bare metal stent (vs. drug eluted stent) and absence of regular follow-up visits. Stepwise multivariate regression analysis concluded that low education level (p=0.01, OR=3.26, 95%CI: 1.31 -8.11), and absence of regular follow-up visits (p=0.04, OR=2.95, 95%CI: 1.01-8.61) were independent predictors of non-adherence of regular physical activity in study subjects. Conclusion: Regular physical activity rates were lower in outpatients with a history of previous coronary revascularization. Education level and regular follow-up visits could influence physical activity adherence in these patients.