tbuckley/cabot-search huggingface dataset:
Increased expression of manganese superoxide dismutase (MnSOD) in the esophagus increases engraftment of bone marrow origin stem cells following irradiation
Authors: Yunyun Niu, Michael W. Epperly, Valerian E. Kagan, Joel S. Greenberger
Journal: Cancer Research (2006)

Proc Amer Assoc Cancer Res, Volume 47, 2006

4415 

Irradiation damage to the esophagus increases apoptosis beginning 5 days after irradiation followed by denuding of the mucosa at approximately 7 days. To determine whether pretreatment with manganese superoxide dismutase-plasmid/liposome (MnSOD-PL) prevented apoptosis following irradiation, C57BL/6NHsd mice were intraesophageally injected with MnSOD-PL and irradiated 24 hours later to 30 Gy to the upper body, and sacrificed 1, 3 or 5 days later. The esophagus was removed, fixed in OCT, sectioned and stained with a Tunel assay for apoptosis. No apoptosis was detected until 5 days after irradiation. Pre-treatment with MnSOD-PL resulted in decreased apoptosis. Lipid peroxidation following irradiation of the esophagus was measured. C57BL/6NHsd mice received intraesophageal MnSOD-PL (200 μg plasmid DNA) and were irradiated 24 hours later along with control mice to 30 Gy to the esophagus. The esophagus was removed at various time points following irradiation and lipid peroxidation measured. There was delayed lipid peroxidation detected 7 days after irradiation. Lipid peroxidation increased in control irradiated mice, but was not detected in MnSOD-PL treated then irradiated mice. Mice pretreated with MnSOD-PL had significantly decreased lipid peroxidation on days 7 and 14 following irradiation compared to control plasmid treated mice (p=0.0053 or 0.0110). To determine if pretreatment of MnSOD-PL allowed successful engraftment of stem cells following irradiation, mice were injected in traesophageally with MnSOD-PL (200 μg plasmid DNA) 24 hours before irradiation to 30 Gy. The mice were then injected I.V. with ROSA (LacZ+) male bone marrow cells at day 1, 3 or 5 after irradiation and sacrificed 14 days later. The esophagus was excised and digested to single cell suspensions, side population (SP) stem cells as well as non-SP cells separated by flow cytometry of Hoechst stained cells. Cells were then analyzed for expression of LacZ. Mice injected with SP cells on day 5 after irradiation had the greatest engraftment of cells positive for the LacZ gene. MnSOD-PL treatment before irradiation further increased engraftment of LacZ positive cells compared to control irradiated mice. The results indicate that pretreatment with MnSOD-PL 24 hours before irradiation results in increased engraftment of stem cells into the irradiated esophagus, associated with reduced production of reactive oxygen species (ROS) , decreased apoptosis and decreased lipid peroxidation.
High Adenosine Deaminase Level Among Healthy Probands of Diamond Blackfan Anemia (DBA) Cosegregates With the DBA Gene Region on Chromosome 19q13
Authors: T.N. Willig, J.L. Pérignon, P. Gustavsson, P. Gane, N. Draptchinskaya, H. Testard, R. Girot, M. Debré, J.L. Stéphan, C. Chenel, J.P. Cartron, Niklas Dahl, G. Tchernia
Journal: Blood (1998)
Abstract P137: Smoking Susceptibility and its Predictors among Nepalese Adolescents: Evidence from the Jhaukhel- Duwakot Health Demographic Surveillance Site, Bhaktapur District, Nepal
Authors: Umesh R Aryal, Max Petzold, Göran Bondjers, Alexandra Krettek
Journal: Circulation (2014)

Introduction: Cognitive susceptibility to smoking is defined as absence of firm commitment not to smoke in the future or if offered a cigarette by best friends. It begins in adolescence and is the first step in the transition to current smoking. Psychosocial risk factors play a crucial role to discourage susceptible adolescents from becoming established smokers. Most studies were conducted in the USA and evidence from low-income countries is limited. Despite the established Tobacco Product Control and Regulatory Bill 2011S in Nepal, cigarette smoking is widely prevalent among adolescents and the absolute number of smokers continues to rise. Hypothesis: We tested the hypothesis that socio-demographic and environmental risk factors associated with susceptibility to smoking among adolescents living in a peri-urban area of Nepal. Methods: We conducted a community cross-sectional study during October-November 2011 in the Jhaukhel - Duwakot Health Demographic Surveillance Site, a peri-urban area in Bhakapur district, 13 km east of the capital Kathmandu in Nepal, where tobacco products are easily available to adolescents. Trained local enumerators conducted face-to-face interviews with 352 randomly selected 14-16 year old non-smoking adolescents. The Nepal Health Research Council and Ethical Committee of Kathmandu Medical College approved this study. Results: The percentage of smoking susceptibility was 49.70% (95% CI: 44.49%-54.93%). In univariate analysis, sex, family members/relatives smoke, teacher smokes, friend smokes, exposure to secondhand smoke, participation in picnic/concerts, exposure to tobacco advertisements, and having seen actors smoke were associated with susceptibility to smoking. While in multiple regression analysis, smoking behavior of family members/relatives, teacher smoking, exposure to pro-tobacco advertisements and involvement in picnic/concerts were associated with susceptibility to smoking. Conclusion: Our results reveal that non-smoking adolescents, depending on their socio-demographic and environmental backgrounds, consider smoking initiation risk factors differently. We therefore suggest that future smoking intervention programs should also take socio-environmental influences into account for efficiently preventing non-smoking adolescents becoming susceptible to smoking.
Human and animal health: strengthening the links
Authors: Tiny C B M De Keuster
Journal: BMJ (2005)

E DITOR—Dog bites are a serious health issue. For example, in Belgium each year 1% of the general population needs medical attention after a dog bite.1 Epidemiological data indicate that 50% of bites are not reported to medical or legal authorities.2 Children seem to be more at risk of being bitten by a dog than any other age group.3 In children under …
DNA image cytometry in malignant and benign sweat gland tumours
Authors: M. Vogelbruch, A. BÖcking, A. RÜtten, A. Kapp, P. Kiehl
Journal: British Journal of Dermatology (2000)

Journal Article DNA image cytometry in malignant and benign sweat gland tumours Get access M. Vogelbruch, M. Vogelbruch Department of Dermatology and Allergology, Hannover Medical University, Ricklinger Straße 5, D‐30449 Hannover, Germany Dr Markus Vogelbruch. E‐mail: vogelbruch@aol.com Search for other works by this author on: Oxford Academic Google Scholar A. BÖcking, A. BÖcking Institute of Cytopathology, University of Düsseldorf, Germany Search for other works by this author on: Oxford Academic Google Scholar A. RÜtten, A. RÜtten Laboratory of Dermatohistopathology, Friedrichshafen, Germany Search for other works by this author on: Oxford Academic Google Scholar A. Kapp, A. Kapp Department of Dermatology and Allergology, Hannover Medical University, Ricklinger Straße 5, D‐30449 Hannover, Germany Search for other works by this author on: Oxford Academic Google Scholar P. Kiehl P. Kiehl Department of Dermatology and Allergology, Hannover Medical University, Ricklinger Straße 5, D‐30449 Hannover, Germany Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 142, Issue 4, 1 April 2000, Pages 688–693, https://doi.org/10.1046/j.1365-2133.2000.03413.x Published: 01 April 2000
National Autism Summit Charts a Path Through a Scientific, Clinical Wilderness
Authors: Brian Vastag
Journal: JAMA (2004)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Clinical Factors Associated With Calcific Aortic Valve Disease
Authors: B.Fendley Stewart, David Siscovick, Bonnie K. Lind, Julius M. Gardin, John S. Gottdiener, Vivienne E. Smith, Dalane W. Kitzman, Catherine M. Otto
Journal: Journal of the American College of Cardiology (1997)

Objectives. The aim of this study was to determine the prevalence of aortic sclerosis and stenosis in the elderly and to identify clinical factors associated with degenerative aortic valve disease. Background. Several lines of evidence suggest that degenerative aortic valve disease is not an inevitable consequence of aging and may be associated with specific clinical factors. Methods. In 5,201 subjects ≥65 years of age enrolled in the Cardiovascular Health Study, the relation between aortic sclerosis or stenosis identified on echocardiography and clinical risk factors for atherosclerosis was evaluated by using stepwise logistic regression analysis. Results. Aortic valve sclerosis was present in 26% and aortic valve stenosis in 2% of the entire study cohort; in subjects ≥75 years of age, sclerosis was present in 37% and stenosis in 2.6%. Independent clinical factors associated with degenerative aortic valve disease included age (twofold increased risk for each 10-year increase in age), male gender (twofold excess risk), present smoking (35% increase in risk) and a history of hypertension (20% increase in risk). Other significant factors included height and high lipoprotein(a) and low density lipoprotein cholesterol levels. Conclusions. Clinical factors associated with aortic sclerosis and stenosis can be identified and are similar to risk factors for atherosclerosis. (J Am Coll Cardiol 1997;29:630–4)
Children Playing Cards
Authors: M Therese Southgate
Journal: JAMA (2005)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Reply from Authors re: Francesco Montorsi, Giorgio Gandaglia. Sentinel Node Biopsy for Prostate Cancer: A Useless Surgical Exercise? Eur Urol 2014;66:999–1000
Authors: Henk G. van der Poel, Nynke S. van den Berg, Gijs H. KleinJan, Fijs W.B. van Leeuwen
Journal: European Urology (2014)
A CASE OF TETRALOGY OF FALLOT WITH VERRUCOSE ENDOCARDITIS
Authors: Lawrence Perlman, Jacob Meyer
Journal: Annals of Internal Medicine (1945)

Case Reports1 January 1945A CASE OF TETRALOGY OF FALLOT WITH VERRUCOSE ENDOCARDITISLAWRENCE PERLMAN, M.D., JACOB MEYER, M.D.LAWRENCE PERLMAN, M.D.Search for more papers by this author, JACOB MEYER, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-22-1-121 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptA majority of the cases of the cyanotic group of congenital cardiac anomalies present the combination known as the Tetralogy of Fallot.Most of these cases are encountered in infants and children, the mean age in Abbott's1series being 12 years of age. White and Sprague2reported a case of Tetralogy of Fallot in which the patient lived to the age of 59 years and nine months. This is the oldest proved case on record. Fallot,3in his original article, reported a case which lived to 36 years of age. Revilloid4also reported a case of the Tetralogy in a...Bibliography1. ABBOTT ME: Atlas of congenital cardiac disease, Am. Heart Assoc., New York City, 1936. Google Scholar2. WHITESPRAGUE PDHB: The Tetralogy of Fallot, Jr. Am. Med. Assoc., 1929, xcii, 787. CrossrefGoogle Scholar3. FALLOT A: Contribution à l'anatomie pathologique de la maladie bleue (cyanosis cardiaque), Marseille Med., 1888, xxv, 77, 138, 207, 270, 341, 403. Google Scholar4. REVILLOID : Quoted by WHITE and SPRAGUE.2 Google Scholar5. LAFITTE : Quoted by ABBOTT.1 Google Scholar6. VOLINIFLAXMAN IFN: Tetralogy of Fallot; case in man who lived to his 41st year, Jr. Am. Med. Assoc., 1938, cxi, 2000. CrossrefGoogle Scholar7. HERNDONVOSSDONOVAN RFAJJ: Tetralogy of Fallot: terminal sepsis with crossed emboli, Am. Heart Jr., 1939, xvii, 553. CrossrefGoogle Scholar8. PESCATOREWOLFFEDIGILIO JAJBVA: Tetralogy of Fallot: correlation of clinical, roentgenologic and postmortem findings, Am. Heart Jr., 1939, xvii, 489. CrossrefGoogle Scholar9. MCGINNWHITE SPD: Progress in the recognition of congenital heart disease, New England Med. Jr., 1936, ccxiv, 763. CrossrefGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: *Received for publication April 23, 1943.From the Department of Medicine, Cook County Hospital. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byThe syndrome of pulmonary stenosis with patent foramen ovale 1 January 1945Volume 22, Issue 1Page: 121-128KeywordsChildrenEndocarditisHospital medicineInfants ePublished: 1 December 2008 Issue Published: 1 January 1945 PDF downloadLoading ...
Abstract P063: A Systematic Review of Current Dietary Policies for Reducing Cardiometabolic Diseases in the Middle East
Authors: Ashkan Afshin, Siyi Shangguan, Marik Nomura-Baba, Yara Abu Awad, Michael Reich, Dariush Mozaffarian
Journal: Circulation (2014)

Background: Cardiometabolic diseases such as CVD and diabetes are rising rapidly in many regions, especially the Middle East. Governments could reduce these burdens by targeting suboptimal diets, but little is known about national dietary policies in this region. Objective: To systematically investigate, summarize, and identify gaps in national dietary policies in 22 Middle Eastern nations. Methods: Using PRISMA and MOOSE guidelines, we systematically searched PubMed, Econ Lit, PAIS, Cochrane library, AGRIS, Web of Science, CABI, and CINAHL for original studies, reviews, and organizational reports on national dietary policies adopted in these countries; Google searches are ongoing. We searched for dietary policies in 6 categories: media/education, labeling/consumer info, taxes/subsidies, school programs, workplace approaches, and direct bans/mandates. We evaluated 13 dietary targets of interest (Figure). Studies were excluded if published prior to 1980, described only local (subnational) policies, or only provided data on policies for food safety, micronutrient deficiency, hunger, or other issues without at least one focus on cardiometabolic risk. Results: From 3866 identified studies, 17 met inclusion criteria. We found 4 types of dietary policies (media/education, labeling/consumer information, taxation/subsidies, direct bans/mandates) in 9 countries of the region (Bahrain, Djibouti, Egypt, Iran, Jordan, Kuwait, Pakistan, Sudan, United Arab Emirates) that targeted 7 dietary factors (fruits, vegetables, whole grains, unprocessed red meat, trans fats, sodium, dietary fiber) . Details of these policies will be presented, as well as current gaps (Figure). Conclusions: Our findings highlight existing national dietary policies that have been adopted to reduce cardiometabolic diseases in the Middle East, as well as remaining major policy gaps, thereby identifying current progress and opportunities for policy innovation.
Abstract 765: Short- and long-term TNF-alpha mediated NF-κB signaling exerts diverging effects on ABCB1/PgP expression
Authors: Wolfgang Walther, Lisa Bauer, Jutta Aumann, Dennis Kobelt, Ulrike S. Stein
Journal: Cancer Research (2014)

Abstract Multidrug resistance (MDR) still represents one major obstacle for cancer chemotherapy. The ABC transporter ABCB1/PgP is an important factor mediating resistance of tumor cells towards cytostatic drug treatment. Among numerous overcoming strategies, persistent treatment of pro-inflammatory cytokines, such as tumor necrosis factor-alpha (TNF-alpha) leads to down-regulation of MDR-associated genes, such as ABCB1. The transcription factor NF-κB/p65 is a known key regulator of ABCB1 expression. We analyzed short- and long-term effects of TNF-alpha regarding modulation of NF-κB/p65 signaling and ABCB1/PgP expression in colon carcinoma cells. Highly resistant ABCB1 endogenously overexpressing HCT15 human colon carcinoma cells were subjected to short- (30-120 min) or long-term (24-96 h) TNF-alpha treatment. TNF-alpha-mediated modulation of ABCB1/PgP expression was analyzed by real-time RT-PCR and Western-blot. The effect of TNF-receptor triggered NF-κB/p65 signaling on ABCB1/PgP expression was analyzed by Western blot, ABCB1 promoter reporter assays and by EMSA. The effects of TNF-alpha on drug accumulation and cytotoxicity were determined by FACScan analysis and MTT cytotoxicity assays. The studies revealed that long-term, but not short-term action of TNF-alpha leads to TNF-receptor 1-mediated down-regulation of ABCB1/PgP expression. It furthermore dampens NF-κB/p65 activation as well as IκBα resynthesis. This is associated with reduced nuclear accumulation of NF-κB/p65 and lack of its binding to the NF-κB/p65 consensus sequence in the ABCB1 promoter. In consequence long-term TNF-alpha treatment mediates significant increase in drug accumulation and sensitization of HCT15 cells towards drug treatment. The study reveals the diverging effects of short- or long-term TNF-alpha action and provides novel insights into mechanism of ABCB1 regulation by this pro-inflammatory cytokine. Citation Format: Wolfgang Walther, Lisa Bauer, Jutta Aumann, Dennis Kobelt, Ulrike S. Stein. Short- and long-term TNF-alpha mediated NF-κB signaling exerts diverging effects on ABCB1/PgP expression. [abstract]. In: Proceedings of the 105th Annual Meeting of the American Association for Cancer Research; 2014 Apr 5-9; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2014;74(19 Suppl):Abstract nr 765. doi:10.1158/1538-7445.AM2014-765
Ultraviolet irradiation may generate plane xanthomas on mycosis fungoides
Authors: N. Fujimoto, H. Mieno, R. Hosokawa, E. Fujimoto, S. Tajima
Journal: British Journal of Dermatology (2012)

Funding sources: none. Conflicts of interest: none declared. Madam, Xanthomas are lesions characterized by accumulation of lipid‐laden macrophages. Plane xanthoma (PX) is the type of xanthoma in half of the reported cases. In contrast to the eruptive, tuberous and tendinous xanthomas, which usually have lipid abnormalities, PXs occur mostly in normolipaemic patients.1 Mycosis fungoides (MF), a cutaneous T‐cell lymphoma, is characterized by infiltration of epidermotropic tumoral T cells in the skin. One of the currently used treatments for MF is psoralen and ultraviolet (UV) A phototherapy (PUVA). PUVA combines the oral or topical administration of psoralen (to sensitize skin) with exposure to UVA radiation. Psoralen has been proposed to induce apoptosis by the following mechanisms: generation of reactive oxygen species, inhibition of DNA synthesis and mitochondrial dysfunction.2 Patient 1 was a 61‐year‐old Japanese woman who had been diagnosed with tumour‐stage MF 10 years before. The serum lipid levels were normal: total cholesterol 145 mg dL−1 (normal 130–230), high‐density lipoprotein (HDL)‐cholesterol 44·7 mg dL−1 (normal 50·3–70·3) and triglycerides 80 mg dL−1 (normal 30–150). Besides chemotherapy, she had received topical PUVA (8‐methoxypsoralen and exposure to UVA radiation) two or three times a week; the maximum dose was 0·7 J cm−2. MF plaques and nodules scattered on the body had gradually been surrounded with yellowish macules (Fig. 1a, b).
Transforming growth factor-β enhances matrix metalloproteinase-2 expression and activity through AKT in fibroblasts derived from angiofibromas in patients with tuberous sclerosis complex
Authors: C.-H. Lee, C.-H. Hong, H.-S. Yu, G.-S. Chen, K.-C. Yang
Journal: British Journal of Dermatology (2010)

Patients with tuberous sclerosis complex (TSC) develop fibrous tumours in the brain, skin, kidney, heart and lungs due to TSC1/2 mutations. In the skin, patients develop angiofibromas that have vascular and fibrotic components in which transforming growth factor (TGF)-β and matrix metalloproteinase (MMP)-2 are important.To investigate if the TGF-β axis and MMP-2 play an important role in the pathogenesis of TSC angiofibromas.Samples from TSC angiofibromas and normal skin were measured for expression of TGF-β and MMP-2 by immunohistochemistry and real-time polymerase chain reaction. Fibroblasts grown from TSC angiofibromas (TSC fibroblasts) were incubated with TGF-β. Expression of ERK, AKT and S6K was measured by Western blotting, and MMP-2 expression and activity were determined by enzyme-linked immunosorbent assay and gelatin zymography, respectively.There was an increase in the expression of TGF-β and MMP-2 in TSC tumours compared with those in normal skin. The baseline expression of MMP-2 was increased in conditioned medium from TSC fibroblasts. In addition, TGF-β enhanced MMP-2 production and activity, which could be abrogated by pretreatment with an AKT inhibitor (LY294002) but not with rapamycin. Finally, there was a significant colocalization of TGF-β and MMP-2 in the TSC tumours.There is an increase of MMP-2 as a result of TGF-β acting through AKT in TSC tumour cells. This regulation of the TGF-β-AKT-MMP-2 axis is independent of mammalian target of rapamycin (mTOR) signalling. In addition to targeting the mTOR pathway, targeting TGF-β simultaneously could block dysregulated tissue remodelling in TSC tumours.