tbuckley/cabot-search huggingface dataset:
she was a model
Authors: Richard Donze
Journal: JAMA (2001)

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Abstract 4236: Antitumor activity of a novel (-)-antofine analog in human lung cancer cells and paclitaxel-resistant lung cancer cells
Authors: Jayoung Song, Song Yi Bae, Yoonho Shin, Won Kyung Kim, Jedo Oh, Tae Joon Choi, Eun Ju Jeong, So Hyun Park, Eun Jeong Jang, Ji In Kang, Hyen Joo Park, Ji-Young Hong, Hwa-Jin Chung, Yongseok Kwon, Sanghee Kim, Sang Kook Lee
Journal: Cancer Research (2014)

Abstract Our previous study revealed that (-)-antofine, a phenanthroindolizidine alkaloid from Cynanchum paniculatum Kitagawa (Asclepiadaceae), exhibited a potent growth inhibition activity against A549 human lung cancer cells. Based on the information several analogs were designed and synthesized to procure new entities. A novel (-)-antofine C-13a analog ((R)-4b) was found to be a potential growth inhibition and antitumor activities in A549 cells. Treatment with (R)-4b for 24 hours did not result in the induction of apoptotic cell death but moderately induced cell cycle arrest in the G0/G1 phase and inhibited the expression of cyclin D1, cyclin E, CDK4 and pRb. In addition, (R)-4b suppressed the phosphorylation of mTOR and its downstream effectors such as 4E-BP-1 and eIF4E. The paclitaxel-resistance was also overcome in human lung cancer cells (A549-Pa) via the suppression of p-glycoprotein expression. Furthermore, (R)-4b significantly inhibited the tumor growth of A549 and A549-Pa xenografts in a nude mouse model. Taken together, these findings suggest that (R)-4b might be a potential candidate for the development of cancer chemotherapeutic agents derived from natural products. Citation Format: Jayoung Song, Song Yi Bae, Yoonho Shin, Won Kyung Kim, Jedo Oh, Tae Joon Choi, Eun Ju Jeong, So Hyun Park, Eun Jeong Jang, Ji In Kang, Hyen Joo Park, Ji-Young Hong, Hwa-Jin Chung, Yongseok Kwon, Sanghee Kim, Sang Kook Lee. Antitumor activity of a novel (-)-antofine analog in human lung cancer cells and paclitaxel-resistant lung cancer cells. [abstract]. In: Proceedings of the 105th Annual Meeting of the American Association for Cancer Research; 2014 Apr 5-9; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2014;74(19 Suppl):Abstract nr 4236. doi:10.1158/1538-7445.AM2014-4236
Abstract P226: D-Dimer Levels and Risk of Stroke: Findings from the EPICOR Study
Authors: Augusto Di Castelnuovo, Claudia Agnoli, Amalia de Curtis, Maria Concetta Giurdanella, Sara Grioni, Amalia Mattiello, Giuseppe Matullo, Salvatore Panico, Carlotta Sacerdote, Rosario Tumino, Giovanni de Gaetano, Maria Benedetta Donati, Licia Iacoviello
Journal: Circulation (2014)

Background: Elevated D-dimer levels are reportedly associated with higher risk of vascular diseases. We investigated the association of baseline D-dimer levels with stroke events occurred in the European Prospective Investigation into Cancer and Nutrition-Italy cohort. Methods: Using a nested case-cohort design, a center-stratified random sample of 832 subjects (66% women, age range 35 to 71) was selected as subcohort and compared with 289 strokes in a mean follow-up of 9 years. D-dimer was measured on fresh citrated plasma by an automated latex-enhanced immunoassay (HemosIL-IL, Milan). The hazard ratios and 95% confidence intervals, adjusted by relevant confounders and stratified by center, were estimated by a Cox regression model using Prentice method. Results: Individuals in the second, third or fourth quartile compared with the lowest quartile of D-dimer had significantly higher risk of stroke (Table). The association was independent from several potential confounders, including C-Reactive protein (Table). It was evident starting from the second quartile (D-dimer &gt;100 ng/ml) and persisted almost unchanged for higher D-dimer levels (Table). No differences were observed in men and women. The increase in risk was essentially the same both for ischemic and hemorrhagic strokes (Table). Conclusions: Our data provide a clear evidence that elevated levels of D-dimer are potential risk factors for ischemic or hemorrhagic strokes.
Abstract 75: Cold Saline Infusion Initiated During CPR and Continued Following Return of Spontaneous Circulation Does Not Impair Resuscitation Nor Induce Heart Failure by Volume Overload After Cardiac Arrest
Authors: Giuseppe Ristagno, Francesca Fumagalli, Sung P Chung, Yinlun Weng, Davide Spada, Paolo Murabito, Shijie Sun, Max H Weil, Wanchun Tang
Journal: Circulation (2010)

Background: Cold saline intravenous infusion (CSI) is now recognized as a rapid method for inducing hypothermia following resuscitation from cardiac arrest. However, CSI initiated during CPR might cause decreases in coronary perfusion pressure (CPP) by volume loading an ischemic right ventricle, leading to increases in right atrial pressure. We explored the effects of CSI on CPP, resuscitation and myocardial function. We hypothesized that CSI would not impair resuscitation nor myocardial function after cardiac arrest. Methods: Ventricular fibrillation was induced in 10 pigs, 38 ± 1 kg, and untreated for 10 mins. CPR, including mechanical chest compression/decompression with LUCAS device, ventilation and epinephrine, was then performed for 5 mins prior to defibrillation. Coincident with the start of CPR, animals were randomized into: 1. systemic cooling by CSI (30 mL/kg 4°C, in 30 mins) followed by surface cooling with a water blanket for 4 hrs; or 2. Control. Aortic and right atrial pressures and CPP were...
Erratum: Vitamin E decreases bone mass by stimulating osteoclast fusion
Authors: Koji Fujita, Makiko Iwasaki, Hiroki Ochi, Toru Fukuda, Chengshan Ma, Takeshi Miyamoto, Kimitaka Takitani, Takako Negishi-Koga, Satoko Sunamura, Tatsuhiko Kodama, Hiroshi Takayanagi, Hiroshi Tamai, Shigeaki Kato, Hiroyuki Arai, Kenichi Shinomiya, Hiroshi Itoh, Atsushi Okawa, Shu Takeda
Journal: Nature Medicine (2012)
The Cliff, Etretat, Sunset
Authors: M. Therese Southgate
Journal: JAMA (2002)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Nagasaki Symposium: Radiation and Human Health Proposal from Nagasaki, by Ed Shigenobu Nagataki, Shunichi Yamashita
Authors: K. F Baverstock
Journal: BMJ (1997)

Ed Shigenobu Nagataki, Shunichi Yamashita Excerpta Medica, $178.25, pp 312 ISBN 0 444 82287 9

The Effects of Atomic Radiation: A Half-Century of Studies from Hiroshima and Nagasaki / William Schull John Wiley, £35, pp 332 ISBN 0 471 12524 5

In general the concept of “mission” is thought to have little place in the scientific enterprise. These two books, however, have in common an element of “mission” in respect of the evaluation of the effects on health of ionising radiation. The Nagasaki Symposium is a direct consequence of Japan's first hand experience of exposure to atom bombs and is an offer of …
Pharmacogenetics in clinical dermatology
Authors: M. Ameen, C.H. Smith, J.N.W.N. Barker
Journal: British Journal of Dermatology (2002)

Systemic therapies are increasingly used in the management of common skin diseases, and drug toxicity and relative lack of efficacy remain significant problems. In addition, we are unable to predict life-threatening adverse reactions such as toxic epidermal necrolysis. Pharmacogenetics, the study of how genetic differences influence the variability of individual patient responses to drugs, aims to distinguish responders from non-responders and predict those in whom toxicity is likely. Successful application of pharmacogenetics should lead to rationalized drug therapy. Recent advances in molecular genetic techniques such as high-throughput genotyping and microarrays have the potential to provide a practicable and economical approach to future pharmacogenetic testing. Pharmacogenetics will change not only the way drugs are selected but will also impact on clinical trial design and the costs of healthcare delivery.
αvβ3 Itegrin pathway controls glioma radioresistance through ILK.
Authors: Elizabeth L. Cohen-Jonathan, Sylvie Monferran, Nicolas Skuli, Caroline Delmas, Gilles Favre, Christine Toulas
Journal: Cancer Research (2006)

Proc Amer Assoc Cancer Res, Volume 47, 2006

5180 

We have previously demonstrated that factors involved in adhesion signalling pathways control radioresistance of human glioma cell lines. The aim of this study was to dissect out the involvement of the biological pathways controlling adhesion and invasion, in the radioresistance mechanisms of glioblastoma cells. We first demonstrated that plating two radiosensitive glioblastoma cell lines (U251 and SF767 cells) on fibronectin and vitronectin induced a significant increase of cell survival after irradiation of these cells due to an inhibition of the radiation-induced mitotic cell death. In the same extend, inhibiting αvβ3 and αvβ5 integrin- which are mainly expressed in these glioma cell lines- with specific inhibitors radiosensitizes radioresistant U87 and SF763 cells. We next explored which integrins are involved in this adhesion-dependant radioresistance pathways by silencing β3 and β5 integrin with specific siRNA and demonstrate that αvβ3 controls the radioresistance of U87 cells. αvβ3 and αvβ5 integrins mainly signal throught the integrin-linked kinase (ILK) or focal adhesion kinase (FAK). By silencing these two proteins with specific siRNA, we showed that ILK but not FAK mediates this adhesion-dependant radioresistance pathway throught Akt and RhoB. Our results bring to light for the first time that adhesion is not only a factor of glioma agressivness but also a factor of resistance to treatment particularly radiotherapy. They also strongly suggest that it could be of great interest to target this pathway to increase the efficiency of radiotherapy for human glioblastoma.
Full genomic analyses of human rotavirus G4P[4], G4P[6], G9P[19] and G10P[6] strains from North-eastern India: evidence for interspecies transmission and complex reassortment events
Authors: A. Mukherjee, S. Ghosh, P. Bagchi, D. Dutta, S. Chattopadhyay, N. Kobayashi, M. Chawla-Sarkar
Journal: Clinical Microbiology and Infection (2010)
Abstract 3729: An individualized approach to bladder cancer treatment using patient-derived cell lines to predict response to chemotherapeutic agents
Authors: LaMont Barlow, Chee Wai Chua, Ming Lei, G. Joel DeCastro, Ketan Badani, Mitchell Benson, James McKiernan, Michael Shen
Journal: Cancer Research (2014)

Abstract Introduction: Chemotherapy (both intravesical and systemic) can reduce the risk of recurrence and progression in various stages of bladder cancer. However, recurrence after treatment failure is associated with an increased risk of progression. There are currently no established methods for predicting patient-specific responses to treatment prior to drug selection. In our studies, we have developed a novel protocol for efficient establishment of cell lines from primary human bladder tumors, which enables in vitro drug sensitivity assays using chemotherapeutic agents. Methods: Using an Institutional Review Board-approved tissue acquisition protocol, informed consent was obtained prior to specimen acquisition for all samples. Specimens were obtained during standard transurethral resection of papillary bladder tumors. Following generation of a single-cell suspension, epithelial cells were isolated using immunomagnetic cell separation and used for establishment of adherent cell cultures using a novel protocol. We performed immunohistochemistry on parental tissue as well as cultured cells to confirm that the urothelial cancer phenotype was maintained during serial passaging. For sensitivity assays, cultured cells were passaged and treated with chemotherapeutic agents, followed by assessment of cell viability using MTT assays. Results: To date, seven specimens from patients with papillary urothelial carcinoma have been obtained, resulting in the establishment of six independent adherent cell lines. All established lines have been serially passaged (as high as P10) without significant decline in growth rate, and maintained expression of CK7, uroplakin III, p53, and Ki67 in patterns similar to parental tissue. Cells from line #7 were treated with mitomycin C, docetaxel, gemcitabine, and rapamycin at three different equivalent concentrations, resulting in a unique sensitivity profile that was reproduced in a replicate experiment performed at a subsequent passage. Conclusions: We have established a novel protocol for culture and rapid expansion of primary cells from human bladder tumors for assays of drug response. Ultimately, we envision that this approach will provide a basis for the design of patient-specific therapeutic regimens for bladder cancer. Citation Format: LaMont Barlow, Chee Wai Chua, Ming Lei, G. Joel DeCastro, Ketan Badani, Mitchell Benson, James McKiernan, Michael Shen. An individualized approach to bladder cancer treatment using patient-derived cell lines to predict response to chemotherapeutic agents. [abstract]. In: Proceedings of the 105th Annual Meeting of the American Association for Cancer Research; 2014 Apr 5-9; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2014;74(19 Suppl):Abstract nr 3729. doi:10.1158/1538-7445.AM2014-3729
Characterization to species level of clinical isolates of the Mycobacterium avium complex by DNA probes, DT1–DT6 PCR and PCR–restriction enzyme analysis
Authors: Xavier Garriga, Pilar Cortés, Francesca March, Purificación Rodriguez, Montserrat Garrigó, Carmen Moreno, Elena Garcia, Pere Coll, Guillem Prats
Journal: Clinical Microbiology and Infection (1999)
Potential of Missing Life-Threatening Arrhythmias After Limiting the Use of Cardiac Telemetry
Authors: Pranav Kansara, Kristi Jackson, Robert Dressler, Henry Weiner, Roger Kerzner, William S. Weintraub, Andrew Doorey
Journal: JAMA Internal Medicine (2015)

This study used the current American Heart Association guidelines to determine whether telemetry alarms affect patient management and found that, even with the alarms designated as emergency, there were few episodes of clinically important arrhythmias and change in patient management was uncommon.
Effects of Clopidogrel in Addition to Aspirin in Patients with Acute Coronary Syndromes without ST-Segment Elevation
Authors: S Yusuf, F Zhao, S R Mehta, S Chrolavicius, G Tognoni, K K Fox, Clopidogrel in Unstable Angina to Prevent Recurrent Events Trial Investigators
Journal: New England Journal of Medicine (2001)

Despite current treatments, patients who have acute coronary syndromes without ST-segment elevation have high rates of major vascular events. We evaluated the efficacy and safety of the antiplatelet agent clopidogrel when given with aspirin in such patients.
Abstract 11840: Disease-Specific Induced Pluripotent Stem Cells Identify the Transcriptional Repression and Epigenetic Modification of NKX2-5, HAND1, and NOTCH1 During Cardiac Development of Hypoplastic Left Heart Syndrome
Authors: Junko Kobayashi, Masashi Yoshida, Suguru Tarui, Shuta Ishigami, Michihiro Okuyama, Yusuke Nagai, Shingo Kasahara, Keiji Naruse, Hiroshi Ito, Shunji Sano, Hidemasa Oh
Journal: Circulation (2014)

Backgrounds:  Although heterozygous mutations have been reported in patients with hypoplastic left heart syndrome (HLHS), no genes have been found to specifically cause this syndrome. The aim of this study is to investigate the complex network of transcriptional regulation and epigenetic modification during the cardiac development of HLHS by using patient-specific induced pluripotent stem (iPS) cells.   Methods:  Cardiac progenitor cells (CPCs) were isolated and four-independent iPS cell lines were generated from HLHS- and bi-ventricular (BV) heart-derived CPCs. Real-Time RT-PCR, exome sequencing, ChIP assay, and luciferase reporter assay were performed and compared with human embryonic stem and 201B7 iPS cells as controls.   Results:  HLHS-derived iPS cells could give rise to cardiomyocytes with significantly lower expression of cardiac troponin-T (TNNT2), NKX2-5, HAND1/2, NOTCH1-HEY1/2 and TBX2 when compared with those from 201B7 and BV-derived iPS cells. To determine the target transcripts responsible for cardiac development of HLHS, luciferase reporter analyses of serum response element (SRE), TNNT2, and natriuretic peptide A (NPPA) were examined. We found that transcriptional activation of SRE, TNNT2, and NPPA was significantly suppressed in HLHS-derived CPCs and iPS cells compared with those from BV heart. No mutations in NKX2-5, HAND1, and NOTCH1 were identified in patients analyzed; however, repressed promoter activities of SRE and TNNT2 in HLHS-derived CPCs and iPS cells could be fully restored by transient transfection of these three transcripts by synergetic fashion. Notably, the transcriptional activation of NPPA was controlled by NKX2-5-dependent mechanism and loss-of-function studies by shRNA confirmed these observations. In addition, ChIP assay showed a marked decrease in histone enhancer marks such as H3K4me2 and acH3 but gain of repressive mark H3K27me3 on NKX2-5 promoter in differentiated HLHS-derived iPS cells.   Conclusions:  These findings suggest that patient-specific iPS cells may provide molecular insights into complex transcriptional and epigenetic mechanisms, at least in part, through combinatorial expression of NKX2-5, HAND1, and NOTCH1 that coordinately contribute to cardiac malformations in HLHS.
Abstract P248: Green Space and Mortality Following Ischemic Stroke
Authors: Elissa Wilker, Chih-Da Wu, Eileen McNeely, Elizabeth Mostofsky, John Spengler, Gregory Wellenius, Murray Mittleman
Journal: Circulation (2014)

Background: Residential proximity to green space has been associated with physical and mental health benefits, but whether green space is associated with post-stroke survival is not well understood. Methods: We identified patients ≥21 years of age admitted to the Beth Israel Deaconess Medical Center (BIDMC) between April 1, 1999 and October 31, 2008 with neurologist-confirmed acute ischemic stroke. Demographics, presenting symptoms, medical history and imaging results were abstracted from medical records at the time of hospitalization for stroke onset. The time of stroke symptom onset or time last seen normal was documented by the attending stroke neurologist at the time of hospital presentation. Participant addresses were geocoded and linked to average Normalized Difference Vegetation Index (NDVI) derived from satellite-based estimates within a 250x250m grid (July 2000-2012), distance to roadways with more than 10,000 cars/day, and 2000 US census block group. We identified deaths through June 2012 using the Social Security Death Index (SSDI). Results: We observed 929 deaths among 1,645 patients with complete data (median follow up: 5 years). In multivariable Cox models adjusted for indicators of medical history and demographic and socioeconomic factors, patients living in locations in the lowest quartile of green space had 28% higher rate of post-stroke mortality (95% Confidence Interval (CI): 4% to 59%) than those living in the highest quartile of green space (p-trend=0.009). This association remained significant after adjustment for residential proximity to a high traffic road. Conclusions: Residential proximity to green space is associated with higher rates of survival after ischemic stroke in multivariable adjusted models. Further work is necessary to elucidate the underlying mechanisms for this association and to better understand susceptibility factors that may contribute to greater mortality in low green space areas.