tbuckley/cabot-search huggingface dataset:
A Fatal Arrhythmia Undetected by a Computerized Cardiac Monitor
Authors: Don Brinberg, Barbara Berkeley, Ira Nash
Journal: Annals of Internal Medicine (1987)

Letters and Corrections1 February 1987A Fatal Arrhythmia Undetected by a Computerized Cardiac MonitorDON BRINBERG, M.D., BARBARA BERKELEY, M.D., IRA NASH, M.D.DON BRINBERG, M.D.Search for more papers by this author, BARBARA BERKELEY, M.D.Search for more papers by this author, IRA NASH, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-106-2-326_1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: A primary factor in the reduction of in-hospital mortality after myocardial infarction is the rapid recognition and subsequent treatment of arrhythmias made possible by continuous monitoring in coronary care units (1). Computers help provide rapid and reliable recognition of arrhythmias and are standardly used in cardiac monitoring (2). We describe a case in which a computer algorithm failed to recognize a life-threatening arrhythmia.A 71-year-old man was admitted to the intensive care unit after 0.5 hours of substernal chest pain, diaphoresis, and shortness of breath. His past medical history included periods of syncope dating to May 1982....References1. KIMBALLKILLOP JI. Aggressive treatment or arrhythmias in acute myocardial infarction: procedures and results. Prog Cardiovasc Dis. 1968;10:483. CrossrefMedlineGoogle Scholar2. VETTERJULIAN ND. Comparison of arrhythmia computer and conventional monitoring in CCU. Lancet. 1975;1:1151-3. CrossrefMedlineGoogle Scholar3. ALCOVERHENNINGJACKSON IRD. A computer-assisted monitoring system for arrhythmia detection in a medical intensive care unit. Crit Care Med. 1984;12:888-91. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByAn algorithm for complete enumeration of the mechanisms of supraventricular tachycardias that use multiple atrioventricular, AV nodal, and/or Mahaim pathwaysA model-based approach to the diagnosis of the cardiac arrhythmiasThe role of magnesium in cardiac arrhythmias 1 February 1987Volume 106, Issue 2Page: 326-326KeywordsAlgorithmsArrhythmiaCardiac care unitComputersDyspneaIntensive care unitsIschemiaMortalityMyocardial infarctionSyncope Issue Published: 1 February 1987 PDF DownloadLoading ...
Weighing the Risk Factors in Coronary Artery Bypass Surgery
Authors: John G. Kral
Journal: JAMA (1992)

<h3>To the Editor.</h3> —By combining men and women in their analysis of 5051 consecutive patients (of whom 1040 [20.6%] were women) Higgins et al<sup>1</sup>may have weakened the power of their excellent clinical severity score for coronary artery bypass patients. Even taking into account the possibility of a misprint in the abstract, where a "body weight of 65 kg or more" was stated to be "predictive of morbidity," the issue of body weight requires some clarification. All three tables in the article identify weight that is 65 kg or less as a "preoperative factor" increasing the odds ratios, and the "Comment" section clearly refers to low body weight as an independent risk factor. Though the present study did not identify female gender as a risk factor (in contrast to other reports), the authors subscribe to the idea that smaller body size might explain increased risk in women. It is
Improved survival in patients receiving medical therapy as compared with banding ligation for the prevention of esophageal variceal rebleeding
Authors: Gin-Ho Lo, Wen-Chi Chen, Chiun-Ku Lin, Wei-Lun Tsai, Hoi-Hung Chan, Tai-An Chen, Hsien-Chung Yu, Ping-I Hsu, Kwok-Hung Lai
Journal: Hepatology (2008)

Both medical therapy and endoscopic variceal ligation (EVL) have proven to be comparable in the prevention of variceal rebleeding. However, the long-term results are still lacking. Our previous study enrolled 121 patients with history of esophageal variceal bleeding and randomized to receive EVL (EVL group, 60 patients) or drug therapy, nadolol plus isosorbide-5-mononitrate (N+I) (N+I group, 61 patients) to prevent variceal rebleeding. The EVL group received ligation regularly until variceal obliteration. The N+I group received N+I during the study period. Patients were followed for up to 8 years. After a median follow-up of 82 months, recurrent upper gastrointestinal bleeding developed in 28 patients (47%) in the EVL group and 49 patients (80%) in the N+I group (P = 0.001). Recurrent bleeding from esophageal varices occurred in 18 patients (30%) in the EVL group and 39 patients (64%) in the N+I group. The actuarial probability of rebleeding from esophageal varices was lower in the EVL group (P = 0.001). A total of 42 patients of the EVL group and 30 patients of the N+I group died (P = 0.013). The multivariate Cox analysis indicated that age, serum albumin, presence of encephalopathy, and treatment were the factors predictive of mortality.Our long-term follow-up study showed that combination of N+I therapy was inferior to banding ligation in the reduction of variceal rebleeding, but with enhanced survival.
The Summer Her Family Moved to Houston
Authors: Walt McDonald
Journal: JAMA (1999)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The correlation of tumor vascularity as imaged by near-infrared technology with tissue distribution of angiogenic and growth promoters.
Authors: SH Tannenbaum, K Phoenix, P Hegde, KP Claffey
Journal: Cancer Research (2009)

Abstract Abstract #907 Background: Angiogenesis is necessary for solid tumors to grow. Rapidly growing tissues, increased metabolic demands as well as the presence of hypoxia and ischemia promote angiogenesis by stimulation of factors like vascular endothelial cell growth factor (VEGF), a key angiogenic factor. Many studies have found that angiogenesis is an independent prognostic factor in both node positive and node negative breast cancer. We have developed a novel technique, ultrasound guided optical tomography in the near-infrared wavelength (NIR-US), that accurately localizes tumor lesion with ultrasound and then images tumor angiogenesis. We have now collected images and tissue from 12 patients treated with preoperative chemotherapy. These tumors are large and heterogeneous with respect to vascular images. We have begun to correlate the tissue expression of a variety of pro-angiogenic proteins with the extent, distribution and pattern of vascularity demonstrated by our NIR-US. Methods: Using NIR-US images, the quantification of vascular content was performed by measuring the total hemoglobin content X volume of distribution of that hemoglobin content. This measure is termed the Blood Volume Index (BVI). In 12 patients studied, the level of tumor vascularity as measured by the initial BVI did not correlate with tumor grade, mitotic index, or estrogen receptor status or most importantly with response to treatment. We analyzed tissue specimens already collected with known patterns of vascular distribution on NIR-US and with known MVD to understand what might be driving the vascular response. Histologic sections were prepared and stained for; endothelial adhesion marker PECAM/CD31, VEGF, the activated stress response kinase P-AMPK, the cell proliferation marker Ki67, and SMA (smooth muscle actin) a marker of vasculature support cells and glucose transporter-1. Each case was quantified using at least 5 40X fields and pixel-by-pixel summation using Image Pro Plus software (Media cybernetics, Inc.) represented as average +/- SD. Results: The tumor BVI as defined by NIR-US did not correlate with either CD31 or SMA expression and was inversely correlated with VEGF levels. The higher VEGF, the lower the BVI. Of particular interest, the highest CD31 signals correlated with high VEGF levels in two, HER-2 positive patients, but not with BVI. Proliferation rate (Ki67), glucose transporter-1 and P-AMPK expression did not correlate with vascular content as measured by NIR-US.&amp;#x2028; Conclusion: Study of the above growth promoters in tissue imaged by NIR-US did not reveal an association between their expression and the vascular content of the tissue. Of interest, VEGF expression varied greatly within the tumor specimens and showed no correlation to BVI.&amp;#x2028; Financial support provided by a Research Grant from the CT Breast Health Initiative. Citation Information: Cancer Res 2009;69(2 Suppl):Abstract nr 907.
Re: Mireia Musquera, Lluis L. Peri, Ricardo Alvarez-Vijande, et al. Orthotopic Kidney Transplantation: An Alternative Surgical Technique in Selected Patients. Eur Urol 2010;58:927–33
Authors: Ramya Nagarajan, Shanmugasundaram Rajaian, Nitin S. Kekre
Journal: European Urology (2011)
Hypothyroidism and Risk of Mild Cognitive Impairment in Elderly Persons
Authors: Ajay K. Parsaik, Balwinder Singh, Rosebud O. Roberts, Shane Pankratz, Kelly K. Edwards, Yonas E. Geda, Hossein Gharib, Bradley F. Boeve, David S. Knopman, Ronald C. Petersen
Journal: JAMA Neurology (2013)

An association of clinical and subclinical hypothyroidism with mild cognitive impairment (MCI) has not been established.To evaluate the association of clinical and subclinical hypothyroidism with MCI in a large population-based cohort.A cross-sectional, population-based study was conducted in Olmsted County, Minnesota. Randomly selected participants were aged 70 to 89 years on October 1, 2004, and were without documented prevalent dementia [CORRECTED]. A total of 2050 participants were evaluated and underwent in-person interview, neurologic evaluation, and neuropsychological testing to assess performance in memory, attention/executive function, and visuospatial and language domains. Participants were categorized by consensus as being cognitively normal, having MCI, or having dementia according to published criteria. Clinical and subclinical hypothyroidism were ascertained from a medical records linkage system.Association of clinical and subclinical hypothyroidism with MCI.Among 1904 eligible participants, the frequency of MCI was 16% in 1450 individuals with normal thyroid function, 17% in 313 persons with clinical hypothyroidism, and 18% in 141 individuals with subclinical hypothyroidism. After adjusting for covariates (age, educational level, sex, apolipoprotein E ε4, depression, diabetes mellitus, hypertension, stroke, body mass index, and coronary artery disease) we found no significant association between clinical or subclinical hypothyroidism and MCI (odds ratio [OR], 0.99 [95% CI, 0.66-1.48] and 0.88 [0.38-2.03], respectively). No effect of sex interaction was seen on these effects. In stratified analysis, the odds of MCI with clinical and subclinical hypothyroidism among men was 1.02 (95% CI, 0.57-1.82) and 1.29 (0.68-2.44) and, among women, was 1.04 (0.66-1.66) and 0.86 (0.37-2.02), respectively.In this population-based cohort of elderly people, neither clinical nor subclinical hypothyroidism was associated with MCI. Our findings need to be validated in a separate setting using the published criteria for MCI and confirmed in a longitudinal study.
Angina of Contention
Authors: Samuel Vaisrub
Journal: JAMA (1975)

After 15 years of relative obscurity, Prinzmetal angina is currently stirring up much interest and a lively controversy. When first described,<sup>1</sup>the variant angina, unprovoked by exercise or emotion, unaccompanied by increase in blood pressure and heart rate, and associated with elevated rather than depressed ST segments, was generally viewed as a curiosity rather than an important entity. Furthermore, Prinzmetal's suggestion that the cause of this syndrome was coronary arterial spasm did not fall on receptive ears at a time when spasm was no longer regarded as a factor in the mechanism of anginal pain. With recent arteriographic demonstration that coronary arteries can undergo spasm and that such spasm has been seen during attacks of variant angina, Prinzmetal's suggestion is inviting a second look. Having examined 20 patients with variant angina and reviewed 60 other cases reported since Prinzmetal called attention to this condition, MacAlpin and his co-workers<sup>2</sup>
The Hospitalist Movement
Authors: Lawrence A. Starr
Journal: Annals of Internal Medicine (1999)

Letters5 October 1999The Hospitalist MovementLawrence A. Starr, MDLawrence A. Starr, MDFaulkner Hospital; Boston, MA 02130 (Starr)Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-131-7-199910050-00019 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:I am deeply disturbed by the articles in the supplement on hospitalists (1). This concept was developed by the insurance industry for economic reasons, and it appears to be gaining support from leadership of the American College of Physicians-American Society of Internal Medicine. The hospitalist concept significantly diminishes and devalues us as a specialty and in the eyes of the patient community. During a patient's hospitalization, we demonstrate our greatest worth to our patients, and they remember us most for helping guide, care, and advocate for them. This is especially important at a time when many patients ...Reference1. Wachter RM, Goldmann DR, eds. The Hospitalist Movement in the United States. Ann Intern Med. 1999; 130(4 Pt 2):337-88. Google Scholar Author, Article, and Disclosure InformationAuthors: Lawrence A. Starr, MDAffiliations: Faulkner Hospital; Boston, MA 02130 (Starr) PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoForeword Robert M. Wachter The Impact of Hospitalists on Medical Education and the Academic Health System Lee Goldman The Hospitalist Movement Charles E. Hofmann Metrics Cited byHospitalists in teaching hospitals: Opportunities but not without danger 5 October 1999Volume 131, Issue 7Page: 543-544KeywordsHospital medicineHospitalistsHospitalizationsOutpatientsPatient advocacyPhysiciansResidency ePublished: 15 August 2000 Issue Published: 5 October 1999 Copyright & PermissionsCopyright © 1999 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
AUTOIMMUNE DISEASE IN NZB/BL MICE
Authors: Robert C. Mellors
Journal: The Journal of Experimental Medicine (1965)

This study, based upon 528 laboratory examinations and 16 complete autopsies of NZB/Bl mice, deals with autoimmune manifestations (as shown by hypergammaglobulinemia, Coombs positive hemolytic anemia, and the occasional presence of lupus- and rheumatoid-like factors) and mainly with the pathology and the pathogenesis of glomerulonephritis in these mice, a model system of membranous glomerulonephritis with spontaneous and insidious onset, progression through chronic stages, and almost certainly induced by immunological, and autoimmune, mechanisms. The earliest and lasting histological change was hyaline thickening of the capillary walls and adjacent intercapillary regions of the glomerular tufts, corresponding in location to polysaccharide-rich capillary basement membrane and mesangial materials. Distributed focally and diffusely in the glomerular tuft and eventually sparing no glomerulus, hyaline, granular, and fibrillar ("spongy fiber") materials produced narrowing of capillary lumens by concentric or eccentric encroachment upon them. In the later stages hyaline lobulation and sclerosis of the glomerular tufts occurred. Thus the lesions corresponded to those seen in human focal and diffuse membranous, chronic lobular, and lastly (intracapillary) sclerosing glomerulonephritis. In all instances of glomerulonephritis the glomerular tufts contained selective localizations of mouse immunoglobulins corresponding in distribution to that of the hyaline and (PAS-positive) polysaccharide-rich materials in the focal and diffuse membranous and lobular lesions and in amounts increasing with the severity of glomerular disease. The mouse immunoglobulins were extracted from frozen sections of glomerulonephritic kidneys and were then capable of recombination with glomerular tufts in sections of autologous or isologous glomerulonephritic kidneys from which in vivo localized immunoglobulins had been extracted. The pattern of recombination with glomerular tufts was similar to that of in invo localized immunoglobulins. The extracted immunoglobulins did not show affinity for mouse red cells (in the indirect Coombs test) nor for autologous or isologous cell nuclei (in the immunofluorescence test). The serum of mice with severe glomerulonephritis contained immunoglobulins with in vitro affinity for extracted autologous or isologous glomerular tufts. Thus circulating as well as localized antibodies were demonstrated. The immunogenic materials (autoantigens) may have been formed in the glomerular tufts or accumulated in them from some other source, such as the circulating plasma; however they corresponded in location to polysaccharide-rich capillary basement membrane and mesangial materials. The spleen was identified at the cellular level as the main site of formation of autoantibodies to red cells, as well as the main site of red cell destruction. Some evidence was brought forth suggesting that these autoantibodies were "heavy" or γM-globulins. More studies are in progress.
Aneurismal Varix in a Stump, after Amputation at the Ankle-joint
Authors: W. Cadge
Journal: BMJ (1850)

THE following case is worthy of record, le8s as a pathological raity, than on acomunt of the clinical instruction it affords.The patient was afflicted with several complaints besides that which I wish now to describe; but to carry the history of the case through the whole of these, would be not only tedious and unnecessary, but would occupy too much time and space.I shall, therefore, simply select such passages from my case-book, as will complete the history of the disease I desire to illustrte: viz., Aneurismal Varix occurring in a stump, after amputation at the anle joint.CAsE.G. K., a young man between thirtyand thirty-five years of age, consulted the late Mr. Liston, in the spring of 1847, on account of stru- mous disease of the tarsal joints of the right lower extremity, resulting from a neglected sprain of the foot.There was pain, lameness, and chronic tbickenig of the synovial membrane.Laterl leather splints were applied; a strong solution of iodine was painted on the part; fer- ruginous tonics were presenbed; and he was sent to the sea-side.These measures failed to improve his health; on the contrar, absces formed and opened, and sinuses were established.The health be- ginning to give a, he returned to London.The question of ampu- tation was raised; but the previous history of the pa,tient gave rise to some difference of opinion.A few years before, the patient, then a lieutenant in the navy, had suffered from an attack of pleuro-pneumonia, which ended in phthisis, and threatened to prove speedily fatal.By great si and care, how- ever, the disease was arrested after it had reached its third stage; and
Culture: In the beak of the beholder?
Authors: Spencer K. Lynn, Irene M. Pepperberg
Journal: Behavioral and Brain Sciences (2001)

We disagree with two of Rendell and Whitehead's assertions. Culture may be an ancestral characteristic of terrestrial cetacean ancestors; not derived via marine variability, modern cetacean mobility, or any living cetacean social structure. Furthermore, evidence for vocal behavior as culture, social stability, and cognitive ability, is richer in birds than Rendell and Whitehead portray and comparable to that of cetaceans and primates.
Abstract 448: Elevated co-expression of HIF-1α and GLUT-1 is associated with poor prognosis for oral squamous cell carcinoma patients
Authors: Alexander W. Eckert, Matthias HW Lautner, Andreas Schütze, Johannes Schubert, Udo Bilkenroth, Helge Taubert
Journal: Cancer Research (2010)

Abstract HIF1α is the key transcriptional regulator of the response to hypoxia in tumors. GLUT-1 is a HIF1α-dependent target gene that is upregulated under hypoxic conditions and enables glucose transport into tumor cells. We sought to identify if co-expression of both of these hypoxia-related proteins, as detected by immunohistochemistry, had prognostic relevance in oral squamous cell carcinomas [OSCC]. Eighty-two OSCC tumor samples were analyzed for their expression levels of both HIF1α and GLUT-1 by immunohistochemistry. Protein expression was assessed using an immunoreactive score system (IRS) and the correlation between gene expression and both clinical and pathohistological parameters were examined. Overexpression of either GLUT-1 or HIF1α was associated with poor overall survival in OSCC patients. Multivariate Cox's proportional-hazards regression analysis (adjusted for tumor size and tumor grade) revealed that moderate expression of GLUT-1 or HIF1α was significantly associated with overall survival (RR=5.07, p=0.002 and RR=4.5, p=0.017, respectively) as compared to the groups with low levels of expression of GLUT-1 or HIF1α. Co-expression of both HIF1α and GLUT-1 were additively and significantly associated with adverse prognoses in patients with OSCC. Patients whose tumors had high levels of expression of both HIF1α and GLUT-1 were found to have a 10.2-fold increased risk of tumor-related death (p=0.001) in the multivariate Cox's proportional-hazards regression analysis. Co-expression of high levels of HIF1α and GLUT-1 is significantly correlated with prognosis in OSCC patients, suggesting that the co-expression of these proteins can be used as both an early diagnostic and independent prognostic marker. Note: This abstract was not presented at the AACR 101st Annual Meeting 2010 because the presenter was unable to attend. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 101st Annual Meeting of the American Association for Cancer Research; 2010 Apr 17-21; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2010;70(8 Suppl):Abstract nr 448.
Breaks from antiretroviral treatment are not the answer for HIV patients
Authors: D. Josefson
Journal: BMJ (2003)

Patients who are infected with multi-drug resistant strains of the HIV virus do not benefit from taking “drug holidays”—structured interruptions in their antiretroviral treatment—a new study has found ( New England Journal of Medicine 2003;349:837-46).

Drug holidays had been proposed as a method to regain drug sensitivity to antiretrovirals as well as to reduce drug toxicity and are increasingly popular among patients infected with HIV. However, new research indicates that interrupting treatment may actually be harmful, even if sensitive strains of the virus return.

Researchers led by Dr Jody Lawrence of the University of California San Francisco Medical Center enrolled …