tbuckley/cabot-search huggingface dataset:
New Peritoneal Dialysate and Blood Chemical Changes
Authors: Dimitrios G. Oreopoulos, George A. Deveber
Journal: Annals of Internal Medicine (1973)

Comments and Corrections1 May 1973New Peritoneal Dialysate and Blood Chemical ChangesDIMITRIOS G. OREOPOULOS, M.D., PH.D., GEORGE A. DEVEBER, M.D., F.R.C.P.(C)DIMITRIOS G. OREOPOULOS, M.D., PH.D.Search for more papers by this author, GEORGE A. DEVEBER, M.D., F.R.C.P.(C)Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-78-5-781 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: In January 1972, at a meeting similar to that described in the editorial note in the January 1973 issue (pp. 144-146), Canadian nephrologists agreed on a change in the composition of peritoneal dialysate. The agreed composition was the same as that reported, except for dialysate calcium, which was decreased to 3.0 meq/litre.During the past 3 months we have had the opportunity to use the new dialysate in our chronic peritoneal dialysis programme. Twelve patients who had been dialyzed 22 hours twice weekly, for an average of 12 months, were changed to the new dialysate. To our...Reference1. OREOPOULOSRABINOVICHMEEMA DSH: Contrasting bone changes in patients on chronic hemodialysis and chronic peritoneal dialysis, in Proceedings of the International Symposium on Clinical Aspects of Metabolic Bone Disease, Henry Ford Hospital, 26-29 June 1972, edited by FRAME B, et al. Amsterdam, Excerpta Medica. In press Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: DIMITRIOS G. OREOPOULOS, M.D., PH.D.; GEORGE A. DEVEBER, M.D., F.R.C.P.(C)Affiliations: PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byPractical Use of Peritoneal Dialysis 1 May 1973Volume 78, Issue 5Page: 781-781KeywordsBloodCalciumPeritoneal dialysis ePublished: 1 December 2008 Issue Published: 1 May 1973 PDF downloadLoading ...
US Republicans try to restrict health insurance cover for abortion
Authors: J. H. Tanne
Journal: BMJ (2011)

Republicans in the US House of Representatives have introduced a bill (called HR3) to prohibit health insurance plans paying for abortions. The speaker of the house, John Boehner, said that the bill was “highest priority.”

The House Judiciary Committee will hold hearings on the proposed bill tomorrow (Tuesday 7 February).

It would place tax penalties on employers who offer health insurance plans that cover abortion and on individuals who buy a health insurance plan of their own that covers abortion. At present most plans cover abortion.

The health reform act passed last March does not permit federal funding for abortions, …
Defective Mismatch Repair and Benefit from Bevacizumab for Colon Cancer: Findings from NSABP C-08
Authors: Kay Pogue-Geile, Greg Yothers, Yusuke Taniyama, Noriko Tanaka, Patrick Gavin, Linda Colangelo, Nicole Blackmon, Corey Lipchik, Seong Rim Kim, Saima Sharif, Carmen Allegra, Nicholas Petrelli, Michael J. O’Connell, Norman Wolmark, Soonmyung Paik
Journal: JNCI Journal of the National Cancer Institute (2013)

National Surgical Adjuvant Breast and Bowel Project protocol C-08 tested the worth of adding 1 year of bevacizumab to oxaliplatin-based standard adjuvant chemotherapy regimen in the treatment of stage II/III colon cancer. Although the overall result was negative, the possibility that a molecularly defined subset could benefit from bevacizumab cannot be ruled out. We performed post hoc Cox regression analyses to test for marker-by-treatment interactions for standard pathological features and survival analyses using the Kaplan–Meier method. All statistical tests were two-sided and considered statistically significant at the .05 level. Patients diagnosed with mismatch repair defective (dMMR) tumors derived statistically significant survival benefit from the addition of bevacizumab (hazard ratio [HR] = 0.52; 95% confidence interval [CI] = 0.29 to 0.94; P = .02) in contrast with no benefit in patients diagnosed with mismatch repair proficient tumors (HR = 1.03; 95% CI = 0.84 to 1.27; p = .78; Pinteraction = .04). Although a post hoc finding, this data suggests that a molecularly defined subset of colon cancer patients may derive clinical benefit from antiangiogenesis agents and underscores the need for independent validation in other clinical trials.
American Research and German Reviewers.
Authors: Heinrich Stern
Journal: JAMA (1903)

New York, July 21, 1903. <i>To the Editor</i>:—Anent your editorial under above title I wish to state that the<i>Biochemisches Centralblatt</i>has since its inception endeavored to furnish abstracts, and in many instances auto-abstracts of all publications pertaining to the special field, and that the American collaborators have been instructed to prepare abstracts of every important article and to report the original works executed in American laboratories.
Closure of a gastrotracheal fistula using a cardiac septal occluder device
Authors: H. Lee, E. Jung, M. Park, H. Chung, J. Choi, K. Lee, J. Lee, H. Kil, Y. Lee
Journal: Endoscopy (2011)

Anastomotic leak is one of the most serious complications after esophagectomy, and it occurs in 5 % – 29 % of patients [1]. Although there are no standardized methods for treating intrathoracic leakage, the treatment options include surgery, external drainage, and endoscopic treatment.
Allocating census data to general practice populations: implications for study of prescribing variation at practice level
Authors: G. Scrivener, D. C E F Lloyd
Journal: BMJ (1995)

<h3>Abstract</h3> Experiencing events as controllable and attributing positive outcomes to own contributions is essential for human well-being. Based on classic psychological theory we test how internal control beliefs impact the affective valuation of task outcomes, neural dynamics and ensuing behavioral preferences. In three consecutive studies with independent samples we show that dynamics in self-evaluative affect specifically increase when agents believe they caused a given task outcome. We demonstrate that these outcomes engage brain networks processing self-referential information in the cortical midline. Here, activity in the ventromedial prefrontal cortex tracks outcome valence regarding both success as well as internal control, and covaries with self-evaluative affect. These affective dynamics also relate to increased functional coupling between the ventral striatum and cortical midline structures. Finally, we show that self-evaluative affect promotes preferences for control, even at a monetary cost. Our investigations extend recent models of positive affect and well-being, and emphasize that control beliefs drive intrinsic motivation.
A model for early afterdepolarizations: induction with the Ca2+ channel agonist Bay K 8644.
Authors: C T January, J M Riddle, J J Salata
Journal: Circulation Research (1988)

Early afterdepolarizations (EADs) are one mechanism proposed to cause certain cardiac arrhythmias. We studied the effect of the Ca2+ channel agonist Bay K 8644 (1 x 10(-8) to 5 x 10(-5) M) on normally polarized sheep and canine cardiac Purkinje fiber short segments. EADs occurred with higher Bay K 8644 concentrations and had an average take-off potential of -34 mV. The initiation of EADs was preceded by lengthening of action potential duration and flattening of the plateau. Induction of EADs with Bay K 8644 was enhanced by low stimulation frequencies, lowering of [K]o, addition of tetraethylammonium chloride, or application of depolarizing constant current pulses during the plateau. EADs were abolished by increasing stimulation frequency, raising [K]o, the addition of tetrodotoxin, lidocaine, ethmozin, verapamil, and nitrendipine, or application of repolarizing constant current pulses. Using current pulses to modify the action potential plateau, a steep inverse relationship was found between the EAD peak voltage and its take-off potential, and EADs could be initiated over only a narrow range of take-off potentials. Thus, interventions that suppressed EADs shortened action potential duration or shifted the plateau away from the voltage range needed to initiate EADs. These observations suggest that mechanisms dependent on both time and voltage underlie EADs, and provide a unifying hypothesis for the induction of the EADs. We propose that induction of EADs requires 1) lengthening of action potential duration within a plateau voltage range where 2) recovery from inactivation and reactivation of an inward current possibly carried through Ca2+ channels can occur.
Functional significance of hepatic arterial flow reserve in patients with cirrhosis
Authors: A Zipprich
Journal: Hepatology (2003)

In cirrhosis, hepatic arterial vasodilatation occurs in response to reduced portal venous blood flow. However, although the hepatic arterial flow reserve is high in patients with cirrhosis, its impact on hepatic function is unknown. This study investigated the effect of adenosine-induced hepatic arterial vasodilatation on different markers of liver function. In 20 patients with cirrhosis (Child-Pugh class A/B/C: n = 2/7/11) adenosine (2-30 μg · min−1 · kg body wt−1) was infused into the hepatic artery and hepatic arterial average peak flow velocities (APV), pulsatility indices (PI), and blood flow volumes (HABF) were measured using digital angiography and intravascular Doppler sonography. Indocyanine green (ICG), lidocaine, and galactose were administered intravenously in doses of 0.5, 1.0, and 500 mg/kg body weight in the presence of adenosine-induced hepatic arterial vasodilatation and, on a separate study day, without adenosine. ICG disappearance, galactose elimination capacity (GEC), and formation of the lidocaine metabolite monoethylglycinxylidide (MEGX) were assessed. Adenosine markedly increased APV and HABF and markedly decreased PI. Serum MEGX concentrations were 63.7 ± 18.2 (median, 62; range, 36-107) and 99.0 ± 46.3 (82.5; 49-198) ng/mL in the absence and presence of adenosine infusion, respectively (P = .001). Adenosine-induced changes in MEGX concentrations were correlated inversely to changes in APV (r = −0.5, P = .02) and PI (r = −0.55, P = .01) and were more marked in Child-Pugh class C compared with Child-Pugh class A patients (57.4 ± 49.9 [44; −14 to 140] vs. 8.4 ± 16.5 [13; −11 to 35] ng/mL, P < .01). In conclusion, hepatic arterial vasodilatation provides substantial functional benefit in patients with cirrhosis. The effect does not depend directly on hepatic arterial macroperfusion and is observed preferentially in patients with decompensated disease.
Airway patency in fatal accidents.
Authors: D W Yates
Journal: BMJ (1977)

The state of the airway in patients who had fatal accidents over a five-year period was correlated with the severity of injury sustained. Necropsy of patients dying in hospital up to 72 hours after an accident showed that those with obstruction of the airway had less severe injuries than those in whome no such obstruction could be found. This suggests that airway obstruction contributed to their death. A similar distinction could not be shown for the patients who died before they reached hospital, indicating that airway management before arrival at hospital was probably satisfactory.
Congenital Syphilis and Necrotizing Funisitis
Authors: Kurt Benirschke
Journal: JAMA (1989)

<h3>To the Editors. —</h3> Fojaco and colleagues<sup>1</sup>suggested that finding a "barber-pole" umbilical cord permits the presumptive diagnosis of congenital syphilis. Other placental pathologists disagree. The diagnosis of congenital syphilis was based on undefined criteria of results of autopsies of infants and serological results that are not accepted as absolute diagnostic criteria.<sup>2</sup>The authors found necrotizing funisitis in 46% of cases of congenital syphilis. This agrees with the findings of previous investigations. It is surprising that no necrotizing funisitis caused by other infections was found. The placental histopathology is not described. How many cases had features of syphilis? The investigators failed to specify tests that excluded other pathogens. Necrotizing funisitis is unmistakable and has been reported for decades. We see many cases, always have maternal VDRL tests done, and usually perform autopsies. Syphilis is increasing in our center also. While we find necrotizing funisitis in some cases, many
Endocrine Response to Substitution of Corticotrophin for Oral Prednisolone in Asthmatic Children
Authors: D. N. S. Malone, J. C. Drever, I. W. B. Grant, I. W. Percy-Robb
Journal: BMJ (1972)

The hypothalamo-pituitary-adrenal axis has been assessed in 17 asthmatic children before and after long-term prednisolone therapy was changed to daily corticotrophin. In 14 of the 17 children the plasma corticosteroid concentration exceeded 15 μg/100 ml within five days of starting corticotrophin. No exacerbation of asthmatic symptoms occurred during conversion. The plasma corticosteroid response to insulin-induced hypoglycaemia was normal in four children about six weeks after conversion to corticotrophin, took up to 36 months to become normal in nine, and remained abnormal in one child throughout the period of the trial.
Screening for Colorectal Cancer in Individuals at Average Risk
Authors: David Lieberman
Journal: JAMA Internal Medicine (2013)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Internal Medicine HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Internal Medicine journal
Cholescintigraphic Diagnosis of Cholecystocolic Fistula
Authors: STEVEN L. EDELL, CYRIL MILUNSKY, LLOYD GARREN
Journal: Clinical Nuclear Medicine (1981)

The diagnosis of a cholecystocolic fistula has often presented a dilemma to the practicing physician. Routine imaging modalities to confirm this diagnosis have not proven extremely successful. The presence of a small fistulous tract from the gallbladder to the colon is often difficult to demonstrate radiographically. However, with the advent of the newer hepatobiliary radioisotopic scanning agents, the ability to visualize the intrahepatic and extrahepatic bile ducts as well as the presence of the intestinal activity of the radiotracers has improved considerably. The authors present a case of cholecystocolic fistula that was adequately demonstrated with a Tc-99m-PIPIDA hepatobiliary scan. This article is the first to report demonstration of this type of fistula with hepatobiliary scanning.
Telling it how it is
Authors: Pippa Keech
Journal: BMJ (2004)

and more often than reported by other authors, although comparison is difficult owing to differences in definition.Appropriate for gestational age infants had a lower risk of neonatal hypoglycaemia than other infants, but the incidence of hypoglycaemia was still unexpectedly high in this group.This deserves attention from paediatricians. ConclusionDespite a high frequency of planned pregnancies, resulting in overall good glycaemic control (early) in pregnancy and a high rate of adequate use of folic acid, maternal and perinatal complications were still greatly increased in women with type 1 diabetes.Neonatal morbidity, especially hypoglycaemia, was also extremely high.Near optimal maternal glycaemic control (HbA 1c ≤ 7.0%) is apparently not good enough.We thank all the gynaecologists, paediatricians, internists, and diabetes nurse educators in the Netherlands for including their patients in this nationwide study; the women who participated for their willingness to fill in the questionnaires; PRISMANT Health Care Information who gave us permission to use their perinatal register of 1998; and TNO Prevention and Health for their statistical analysis of this register.
Novel human and mouse genes encoding an acid phosphatase family member and its downregulation in W/WV mouse jejunum
Authors: I Takayama
Journal: Gut (2002)

<b>Background and aims:</b> Interstitial cells of Cajal (ICC) are pacemakers and mediators of motor neurotransmission in gastrointestinal smooth muscles. ICC require cellular signalling via Kit, a receptor tyrosine kinase, for development and maintenance of phenotype. Much of the evidence demonstrating the functions of ICC comes from studies of <i>W/W</i><sup><i>V</i></sup> mice, which have reduced Kit function and reductions in specific populations of ICC. The aim of the present study was to differentially examine gene expression in the small intestines of wild-type and <i>W/W</i><sup><i>V</i></sup> mutant mice. <b>Methods and results:</b> RNA from the jejunums of wild-type and <i>W/W</i><sup><i>V</i></sup> mutants was analysed using a differential gene display method. Eighteen queries were identified as novel genes that were differentially displayed in wild-type and <i>W/W</i><sup><i>V</i></sup> mice. One candidate gene, encoding a novel acid phosphatase-like protein, was significantly suppressed in fed and starved <i>W/W</i><sup><i>V</i></sup> mice. The full length clone of the murine gene and its human counterpart were designated acid phosphatase-like protein 1 (ACPL1). Human ACPL1 cDNA encodes a protein of 428 amino acids with homology to human prostatic acid phosphatase protein. This gene is located at 1q21. ACPL1 was abundantly expressed in the human small intestine and colon. Gene products were found to be cytoplasmic in transfected COS-7 cells. Reverse transcription-polymerase chain reaction analysis revealed expression of ACPL1 mRNA within single isolated ICCs. <b>Conclusions:</b> Gene analysis showed that ACPL1 was differentially expressed in the small intestines of normal and <i>W/W</i><sup><i>V</i></sup> mice. ICC within the small intestine expressed mRNA for ACPL1. Specific downregulation of ACPL1 in the jejunums of <i>W/W</i><sup><i>V</i></sup> mice and high expression in human intestinal tissue suggest that the ACPL1 gene could be associated with ICC function in mice and humans.
Urine calcium excretion during treatment of psoriasis with topical calcipotriol
Authors: J. BERTH-JONES, J.F. BOURKE, S.J. IQBAL, P.E. HUTCHINSON
Journal: British Journal of Dermatology (1993)

Urine calcium excretion is a very sensitive method of detecting vitamin D intoxication, and may rise in the absence of any apparent change in the serum level. Little attention has been paid to urine calcium levels during the large trials performed to assess the efficacy and safety of calcipotrioi in psoriasis vulgaris. There are some urine calcium data from short-term studies of average dose rates of calcipotriol. However, there are no published data on long-term usage, nor on the use of dose rates at the upper end of the licensed range (100 g/week). In a group of 20 patients, who were using typical quantities of calcipotriol ointment (50 μg/g) to treat psoriasis vulgaris, urine calcium excretion was measured prior to treatment, and then monthly for 1 2 months. There was no significant change in urine calcium over the year. In a separate group of 10 patients, who were using calcipotriol in the same concentration, at the maximum recommended rate of 100 g/week, urine calcium was measured at baseline, and after 2 and 4 weeks. There was a statistically significant rise in calcium excretion. This is the first trial to demonstrate that topical calcipotriol affects calcium homeostasis when used within the recommended dose range. Further studies are necessary to determine more precisely the magnitude and variability of this effect in a large group of individuals. For the present, caution is required when prescribing calcipotriol for any patient with known hypercalciuria or a history of renal stone formation. Consideration should be given to monitoring urine calcium excretion during prolonged use at dose rates approaching the recommended maximum.
Perturbation of fetal hematopoiesis in a mouse model of Down syndrome’s transient myeloproliferative disorder
Authors: Yehudit Birger, Liat Goldberg, Timothy M. Chlon, Benjamin Goldenson, Inna Muler, Ginette Schiby, Jasmin Jacob-Hirsch, Gideon Rechavi, John D. Crispino, Shai Izraeli
Journal: Blood (2013)
Is London overbedded?
Authors: B Jarman
Journal: BMJ (1993)

To examine whether there are too many hospital beds in London.Analysis of data from the Hospital In-Patient Enquiry, Mental Health Enquiry, health service indicators, and Emergency Bed Service.England, London, and inner London.Hospital admission rates for acute plus geriatric services for London residents were very similar to the national values in all age groups. In the special case considered in the Tomlinson report--acute services in inner London--the admission rate was 22% above the value for England. However, the admission rate of inner deprived Londoners was 9% below that of comparable areas outside London. For psychiatry, admission rates in London roughly equalled those in comparable areas. When special health authorities were excluded, in 1990-1 there were 4% more acute plus geriatric beds available per resident in London than in England. Bed provision has been reduced more rapidly in London than nationally. Extrapolating the trend of bed closures forward indicates that beds (all and acute) per resident in London are now at about the national average. Data from the Emergency Bed Service indicate that the pressure on available hospital beds in London has been increasing since 1985.Data regarding bed provision and utilisation for all specialties by London residents do not provide a case for reducing the total hospital bed stock in London at a rate faster than elsewhere. Bed closures should take account of London's relatively poorer social and primary health care circumstances, longer hospital waiting lists, poorer provision of residential homes, and evidence from the Emergency Bed Service of increasing pressure on beds. Higher average costs in London, some unavoidable, are forcing hospital beds to be closed at a faster rate in London than nationally.