Update in Hematology and Oncology
Authors: Reed E. Drews
Journal: Annals of Internal Medicine (2010)

Updates18 May 2010Update in Hematology and OncologyReed E. Drews, MD and Lawrence N. Shulman, MDReed E. Drews, MDFrom Beth Israel Deaconess Medical Center, Harvard Medical School, and Dana-Farber Cancer Institute and Brigham and Women's Hospital, Boston, Massachusetts. and Lawrence N. Shulman, MDFrom Beth Israel Deaconess Medical Center, Harvard Medical School, and Dana-Farber Cancer Institute and Brigham and Women's Hospital, Boston, Massachusetts.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-152-10-201005180-00244 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail This update reviews hematology and oncology articles published in 2009 that we consider particularly interesting to practicing internists.In the field of hematology, we selected articles that addressed key topics, including the use of dabigatran, a new direct oral thrombin inhibitor, in patients with venous thromboembolism (VTE) and atrial fibrillation; duration of anticoagulation in patients with deep venous thrombosis (DVT); estimation of warfarin dose using clinical and pharmacogenetic data; use of oral vitamin K to correct excessive anticoagulation in patients receiving warfarin; and adverse effects of erythropoiesis-stimulating agents in renal transplant recipients and patients with type 2 diabetes mellitus and ...References1. Singh AK, Szczech L, Tang KL, Barnhart H, Sapp S, Wolfson M, et al; CHOIR Investigators. Correction of anemia with epoetin alfa in chronic kidney disease. N Engl J Med. 2006;355:2085-98. [PMID: 17108343] CrossrefMedlineGoogle Scholar2. Drüeke TB, Locatelli F, Clyne N, Eckardt KU, Macdougall IC, Tsakiris D, et al; CREATE Investigators. Normalization of hemoglobin level in patients with chronic kidney disease and anemia. N Engl J Med. 2006;355:2071-84. [PMID: 17108342] CrossrefMedlineGoogle Scholar3. Schröder FH, Hugosson J, Roobol MJ, Tammela TL, Ciatto S, Nelen V, et al; ERSPC Investigators. Screening and prostate-cancer mortality in a randomized European study. N Engl J Med. 2009;360:1320-8. [PMID: 19297566] CrossrefMedlineGoogle Scholar4. Rosell R, Moran T, Queralt C, Porta R, Cardenal F, Camps C, et al; Spanish Lung Cancer Group. Screening for epidermal growth factor receptor mutations in lung cancer. N Engl J Med. 2009;361:958-67. [PMID: 19692684] CrossrefMedlineGoogle Scholar5. Albini A, Pennesi G, Donatelli F, Cammarota R, De Flora S, Noonan DM. Cardiotoxicity of anticancer drugs: the need for cardio-oncology and cardio-oncological prevention. J Natl Cancer Inst. 2010;102:14-25. [PMID: 20007921] CrossrefMedlineGoogle Scholar Author, Article, and Disclosure InformationAffiliations: From Beth Israel Deaconess Medical Center, Harvard Medical School, and Dana-Farber Cancer Institute and Brigham and Women's Hospital, Boston, Massachusetts.Article relevant to primary care general internistsArticle relevant to hospitalistsDisclosures: None disclosed. Forms can be viewed at www.acponline.org/authors/icmje/ConflictOfInterestForms.do?msNum=M10-0194.Corresponding Author: Reed E. Drews, MD, Division of Hematology-Oncology, E/RA-430, Beth Israel Deaconess Medical Center, 330 Brookline Avenue, Boston, MA 02215; e-mail, [email protected]harvard.edu.Current Author Addresses: Dr. Drews: Division of Hematology-Oncology, E/RA-430, Beth Israel Deaconess Medical Center, 330 Brookline Avenue, Boston, MA 02215.Dr. Shulman: Dana-Farber Cancer Institute and Brigham and Women's Hospital, 44 Binney Street, Boston, MA 02215. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byGraphene oxide and reduced graphene oxide: Efficient cargo platforms for cancer theranosticsTargeting histone deacetylase SIRT1 selectively eradicates EGFR TKI-resistant cancer stem cells via regulation of mitochondrial oxidative phosphorylation in lung adenocarcinomaEfficacy and safety of Huaier granules combined with chemotherapy for gastric cancerAdvances in understanding of mechanism of anti-hepatocellular carcinoma effects of curcuminMetformin incombination with curcumin inhibits the growth, metastasis, and angiogenesis of hepatocellular carcinoma in vitro and in vivoCombinational strategies of metformin and chemotherapy in cancersMetformin Decreases the Dose of Chemotherapy for Prolonging Tumor Remission in Mouse Xenografts Involving Multiple Cancer Cell TypesUpdate in Hematology and Oncology: Evidence Published in 2010Richard L. Schilsky, MD and Mark Crowther, MD 18 May 2010Volume 152, Issue 10Page: 655-662KeywordsBreast cancerErythropoietinHemoglobinHemorrhageInternational normalized ratioMortalityMutationPharmacogeneticsProstate cancerVitamin K ePublished: 18 May 2010 Issue Published: 18 May 2010 Copyright & PermissionsCopyright © 2010 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...