H_2-Receptor Antagonists in the Treatment of Peptic Ulcer
Authors: JON I. ISENBERG
Journal: Annals of Internal Medicine (1976)

Editorials1 February 1976H2-Receptor Antagonists in the Treatment of Peptic UlcerJON I. ISENBERG, M.D.JON I. ISENBERG, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-84-2-212 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptAlthough there has been a definite decrease in the incidence of peptic ulcer during the past 10 to 20 years, particularly in duodenal ulcer, it still remains one of the major causes of absenteeism and morbidity in the United States (1). Antacids and anticholinergics remain the mainstay of ulcer therapy despite lack of clear cut evidence that they relieve ulcer pain, expedite ulcer healing, or decrease recurrences and complications. Because antacids buffer gastric acid and anticholinergics inhibit the secretion of acid and pepsinogen, their use in the therapy of peptic ulcer is rational. Their therapeutic effect, however, is not striking...References1. MENDELOFF A: What has been happening to duodenal ulcer? Gastroenterology 67:1020-1022, 1974 CrossrefMedlineGoogle Scholar2. PIPERHEAP DT: Medical management of peptic ulcer with reference to anti-ulcer agents in other gastrointestinal diseases. Drugs 3:366-403, 1972 CrossrefMedlineGoogle Scholar3. BLACKDUNCANDURANT JWC: Definition and antagonism of histamine H2-receptors. Nature (Lond) 236:385-390, 1972 CrossrefMedlineGoogle Scholar4. ASHSCHILD AH: Receptors mediating some action of histamine. Br J Pharmacol Chemother 27:427-439, 1966 CrossrefMedlineGoogle Scholar5. WYLLIEHESSELBOBLACK JTJ: Effects in man of histamine H2-receptor blockade by burimamide. Lancet 2:1117-1120, 1972 CrossrefMedlineGoogle Scholar6. MAINARDIMAXWELLSTURDEVANT MVR: Metiamide, an H2-receptor blocker, as inhibitor of basal and meal-stimulated gastric acid secretion in patients with duodenal ulcer. 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N Engl J Med 290:738-740, 1974 CrossrefMedlineGoogle Scholar12. GROSSMANKONTUREK MS: Inhibition of acid secretion in dog by metiamide, a histamine antagonist acting on H2 receptors. Gastroenterology 66:517-521, 1974 CrossrefMedlineGoogle Scholar13. RICHARDSONWALSH CJ: The value of a histamine H2-receptor antagonist in the management of patients with Zollinger-Ellison syndrome. N Engl J Med, in press Google Scholar14. THOMPSONVENABLESMILLER MCI: Metiamide therapy in the Zollinger-Ellison syndrome. Gut 16:396-397, 1975 MedlineGoogle Scholar15. FORRESTSHEARMANSPENCE JDR: Neutropenia associated with metiamide. Lancet 1:392-393, 1975 CrossrefMedlineGoogle Scholar16. HENNISENBERGMAXWELL RJV: Inhibition of gastric acid secretion by cimetidine in patients with duodenal ulcer. N Engl J Med 293:371-375, 1975 CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Gastroenterology Section Veterans Administration Wadsworth Hospital Center Los Angeles, California PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByRole of Phospholipids in Protection of the GI MucosaZollinger-Ellison syndrome associated with a history of alcohol abuse: Coincidence or consequence?Is cimetidine associated with neutropenia?Toxic effects of the histamine H2 receptor antagonist metiamide on bone-marrow haemopoietic and stromal progenitor cells in vitroH2 receptor antagonists and human granulopoiesisHistidine decarboxylase inhibition: A novel approach towards the development of an effective and safe gastric anti-ulcer drugEFFECTS OF CIMETIDINE ON HAEMATOPOIESIS in vitroCimetidine and Granulopoiesis: Bone Marrow Culture Studies in Normal Man and Patients with Cimetidine-associated NeutropeniaPrevention of stress ulcerations using H2 receptor antagonistsDouble-blind clinical comparison between a gastrin-receptor antagonist, proglumide, and a histamine H 2 -blocker, cimetidineDrug Evaluation DataInterrelationships Between Histamine, Prostaglandins, and Cyclic AMP in Gastric Secretion: A HypothesisDiagnosis and Treatment of Duodenal Ulcer in Infancy and ChildhoodGastroenterology: An Annotated Bibliography of Recent Literature References to Journal Articles and Other Papers 1 February 1976Volume 84, Issue 2Page: 212-214KeywordsDuodenal ulcersMorbidityPeptic ulcersUlcers Issue Published: 1 February 1976 PDF DownloadLoading ...