TRIMETHYLCOLCHICINIC ACID IN THE TREATMENT OF ACUTE GOUT
Authors: S L WALLACE
Journal: Annals of Internal Medicine (1961)

Article1 February 1961TRIMETHYLCOLCHICINIC ACID IN THE TREATMENT OF ACUTE GOUTSTANLEY L. WALLACE, M.D., F.A.C.P.STANLEY L. WALLACE, M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-54-2-274 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptColchicine is an effective drug in the treatment of acute gout. It has diagnostic as well as therapeutic value. Nevertheless, gastrointestinal side effects—hyperperistalsis, diarrhea, nausea, and vomiting—occur in almost all patients to whom therapeutically sufficient colchicine has been given. Other much less frequent but more serious toxic manifestations from relatively small doses have been reported, including agranulocytosis and bone marrow depression,1 loss of hair,1, 2 neurologic damage,3 and death.4Other colchicine analogs have been introduced in the treatment of acute gout in the hope of separating the therapeutic and toxic effects of colchicine. Desacetylmethylcolchicine was the first colchicine analog to...Bibliography1. BrownSeed WOL: Effect of colchicine on human tissues. Amer. J. Clin. Path. 15: 189, 1945. CrossrefGoogle Scholar2. MalkinsonLynfield FDYL: Colchicine alopecia. J. Invest. Dermat. 33: 371, 1959. CrossrefMedlineGoogle Scholar3. LayaniAschkenasyMouzon FAM: Intoxication aigue par la colchicine; important alterations de la leucopoiese. Bull. Mem. Soc. Hôp. Paris 63: 10, 1947. Google Scholar4. McLeodPhillips JGL: Hypersensitivity to colchicine. Ann. Rheum. Dis. 6: 224, 1947. CrossrefGoogle Scholar5. 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Author, Article, and Disclosure InformationAffiliations: Brooklyn, N. Y.*Received for publication July 26, 1960.Presented in part at the Forty-first Annual Meeting of The American College of Physicians, San Francisco, California, April 7, 1960.†This work was supported by grants from Roussel, Inc., New York, N. Y., and the New York Chapter of the Arthritis and Rheumatism Foundation. Trimethylcolchicinic acid was supplied by Roussel, Inc. through the courtesy of Dr. A. L. Courtin.From the Departments of Medicine of State University of New York College of Medicine at New York City, The Jewish Hospital, and Kings County Hospital, Brooklyn, N. Y.Requests for reprints should be addressed to Stanley L. Wallace, M.D., F.A.C.P., 1122 Ocean Avenue, Brooklyn 30, New York. 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HILL, M.D., F.A.C.P., JOSEPH LEE HOLLANDER, M.D., F.A.C.P., WILLIAM M. MIKKELSEN, M.D., F.A.C.P., MAX M. MONTGOMERY, M.D., F.A.C.P., CARL M. PEARSON, M.D., F.A.C.P., HUGH A. SMYTHE, M.D., F.R.C.P. (C), L. EMMERSON WARD, M.D., F.A.C.P., HOWARD J. WEINBERGER, M.D., F.A.C.P.Recurrent acute (?gouty) arthritis in chronic renal failure treated with periodic hemodialysisGoutInfluence of griseofulvin upon acute gouty arthritisGriseofulvin in Acute Gout 1 February 1961Volume 54, Issue 2Page: 274-279KeywordsArthritisBone marrowColchicineDiarrheaDrugsGoutHospital medicineNausea ePublished: 1 December 2008 Issue Published: 1 February 1961 PDF downloadLoading ...