Screening for Vitamin D Deficiency
Authors: Kirti Kain
Journal: Annals of Internal Medicine (2015)

Letters19 May 2015Screening for Vitamin D DeficiencyKirti Kain, MDKirti Kain, MDFrom University of Leeds, Leeds, United Kingdom.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/L15-5094-2 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:The U.S. Preventive Services Task Force has concluded that the current evidence is insufficient to assess the balance of benefits and harms of screening for vitamin D deficiency in asymptomatic adults. As LeBlanc and colleagues' review (1) shows, this evidence comprises studies whereby supplementation (variable doses of vitamin D2 or D3 with or without calcium) has been monitored mainly by measuring total concentrations of 25-(OH)D. Instead, future studies should focus on assessing concentrations of bioavailable vitamin D.Concentrations of total 25-(OH)D and 1,25-dihydroxyvitamin D measured routinely in daily practice are known to differ from those of bioavailable ...References1. LeBlanc ES, Zakher B, Daeges M, Pappas M, Chou R. Screening for vitamin D deficiency: a systematic review for the U.S. Preventive Services Task Force. Ann Intern Med. 2015;162:109-22. [PMID: 25419719] doi:10.7326/M14-1659 LinkGoogle Scholar2. Holick MF. Bioavailability of vitamin D and its metabolites in black and white adults [Editorial]. N Engl J Med. 2013;369:2047-8. [PMID: 24256384] doi:10.1056/NEJMe1312291 CrossrefMedlineGoogle Scholar3. Kain K. Physical activity, ultraviolet B derived 1,25-vitamin D3, and vascular regeneration. Circulation. 2015. [Forthcoming]. MedlineGoogle Scholar4. Jegger D, da Silva R, Jeanrenaud X, Nasratullah M, Tevaearai H, von Segesser LK, et al. Ventricular-arterial coupling in a rat model of reduced arterial compliance provoked by hypervitaminosis D and nicotine. Am J Physiol Heart Circ Physiol. 2006;291:H1942-51. [PMID: 16699077] CrossrefMedlineGoogle Scholar5. Rajasree S, Umashankar PR, Lal AV, Sarma PS, Kartha CC. 1,25-dihydroxyvitamin D3 receptor is upregulated in aortic smooth muscle cells during hypervitaminosis D. Life Sci. 2002;70:1777-88. [PMID: 12002522] CrossrefMedlineGoogle Scholar Author, Article, and Disclosure InformationAffiliations: From University of Leeds, Leeds, United Kingdom.Disclosures: Authors have disclosed no conflicts of interest. Forms can be viewed at www.acponline.org/authors/icmje/ConflictOfInterest Forms.do?msNum=L15-0124. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoScreening for Vitamin D Deficiency: A Systematic Review for the U.S. Preventive Services Task Force Erin S. LeBlanc , Bernadette Zakher , Monica Daeges , Miranda Pappas , and Roger Chou Screening for Vitamin D Deficiency: A Systematic Review for the U.S. Preventive Services Task Force Erin S. LeBlanc , Bernadette Zakher , Monica Daeges , Miranda Pappas , and Roger Chou Screening for Vitamin D Deficiency Mark J. Bolland , Andrew Grey , and Ian R. Reid Screening for Vitamin D Deficiency Toshihiro Sugiyama , Yoon Taek Kim , and Hiromi Oda Screening for Vitamin D Deficiency Erin S. LeBlanc , Roger Chou , and Miranda Pappas Screening for Vitamin D Deficiency Toshihiro Sugiyama , Yoon Taek Kim , and Hiromi Oda Screening for Vitamin D Deficiency Erin S. LeBlanc , Roger Chou , and Miranda Pappas Screening for Vitamin D Deficiency Mark J. Bolland , Andrew Grey , and Ian R. Reid Metrics 19 May 2015Volume 162, Issue 10Page: 737KeywordsAttentionAutoimmune diseasesCalciumPrevention, policy, and public healthProteinsPublic policyStiffnessVitamin DVitamin D deficiency ePublished: 19 May 2015 Issue Published: 19 May 2015 CopyrightCopyright © 2015 by American College of Physicians. All Rights Reserved.PDF DownloadLoading ...