INTERMITTENT CLAUDICATION: ITS TREATMENT WITH AN INSULIN-FREE, DEPROTEINATED PANCREATIC EXTRACT (DEPROPANEX)
Authors: T. J. Fatherree, Cecil Hurst
Journal: Annals of Internal Medicine (1942)

Article1 August 1942INTERMITTENT CLAUDICATION: ITS TREATMENT WITH AN INSULIN-FREE, DEPROTEINATED PANCREATIC EXTRACT (DEPROPANEX)T. J. FATHERREE, M.D., F.A.C.P., CECIL HURST, M.D.T. J. FATHERREE, M.D., F.A.C.P.Search for more papers by this author, CECIL HURST, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-17-2-325 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe term intermittent claudication was first used in 1831 by the French veterinarian Bouley1to describe a condition of limping in the horse, developing after a short period of exercise, recovering rapidly with rest, and found to be associated with an obliterative disease affecting the main artery of the leg. Subsequently several investigators, notably Brodie,2Charcot,3and Erb,4observed and described a similar condition in human patients, and as a result of their observations it was established that the usual anatomical defect associated with this condition is arterial occlusion and that the limping or lameness results most commonly from pain....Bibliography1. BOULEY : Rec. d. Med. Veterin. Prat., 1831, viii, 517. Google Scholar2. BRODIE BC: Lectures illustrative of various subjects in pathology and surgery, 1846, London, p. 361. Google Scholar3. CHARCOT : Compt.-rend. Soc. de biol., 1859, v, Ser. II, 225. Google Scholar4. ERB W: Ueber das intermittirende Hinken und andere nervöse Störungen in Folge von Gefässkrankungen, Deutsch. Ztschr. f. Nervenheilk., 1898, xiii, 1. Google Scholar5. LEWISPICKERINGROTHSCHILD TGWP: Observations upon muscular pain in intermittent claudication, Heart, 1931, xv, 359. Google Scholar6. PICKERINGWAYNE GWEJ: Observations on angina pectoris and intermittent claudication in anemia, Clin. Sci., 1934, i, 305. Google Scholar7. WRIGHT IS: Conservative treatment of occlusive arterial disease, Arch. Surg., 1940, xl, 163. CrossrefGoogle Scholar8. FREYKRAUT EHH: Ueber einen von der Niere ausgeschiedenen, die Hertztätigkeit anregenden Stoff, Ztschr. f. physiol. Chem., 1926, clvii, 32. CrossrefGoogle Scholar9. WOLFFE JB: The therapy of tissue extract, Jr. Am. Therap. Soc., 1931, xxxi, 31. Google Scholar10. BARKERBROWNROTH NWGEGM: Effect of tissue extracts on muscle pains of ischemic origin (intermittent claudication), Am. Jr. Med. Sci., 1935, clxxxix, 36. CrossrefGoogle Scholar11. DURYEE AW: Tissue extract in the treatment of peripheral vascular disease, Jr. Am. Therap. Soc., 1935, xxxv, 124. Google Scholar12. FISHERDURYEEWRIGHT MMAWIS: Deproteinated pancreatic extract (Depropanex). Effect in the treatment of intermittent claudication due to arteriosclerosis obliterans, Am. Heart Jr., 1939, xviii, 425. CrossrefGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Tacoma, Washington*Received for publication February 19, 1941.From the McKay Memorial Research Hospital, Soap Lake, Washington. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byMedical Management of Peripheral Arterial Occlusive DiseasesA Two-Step Test of Exercise Tolerance in Intermittent Claudication 1 August 1942Volume 17, Issue 2Page: 325-332KeywordsArteriesExerciseInsulinSoaps Issue Published: 1 August 1942 PDF downloadLoading ...