A CLINICAL EVALUATION OF ORAL VERILOID IN THE TREATMENT OF HYPERTENSIVE DISEASE
Authors: E J SAPHIRE
Journal: Annals of Internal Medicine (1954)

Article1 December 1954A CLINICAL EVALUATION OF ORAL VERILOID IN THE TREATMENT OF HYPERTENSIVE DISEASEENOCH J. SAPHIRE, M.D.ENOCH J. SAPHIRE, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-41-6-1211 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe focus of attention in the treatment of hypertensive disease has turned toward the use of hypotensive drugs. Among a number of hypotensive drugs which have stimulated interest are preparations of Veratrum viride and its derivatives. V. viride is not new to pharmacologic or clinical experience. A rebirth of interest in this drug followed more accurate standardization and better knowledge of its composition and actions.4, 10, 5An oral preparation of Veriloid is evaluated in this study. Veriloid is a standardized mixture of hypotensive alkaloids ofV. viride20whose main pharmacologic actions produce hypotension, bradycardia and emesis. The chemical structure...Bibliography1. BarrowSikes JGCR: The use of purified Veratrum viride alkaloids in the treatment of essential hypertension, Am. Heart J. 41: 742, 1951. CrossrefMedlineGoogle Scholar2. BorisonFairbanks HCVF: Mechanism of veratrum indirect emesis of the cat, J. Pharmacol. and Exper. Therap. 105: 317, 1952. MedlineGoogle Scholar3. CoeBestKinsman WSMMJM: Veratrum viride in the treatment of hypertensive vascular disease, J. A. M. A. 143: 5, 1950. CrossrefMedlineGoogle Scholar4. CraigJacobs LCWA: The veratrum alkaloids, J. Biol. Chem. 149: 451, 1943. CrossrefGoogle Scholar5. FreisStanton EDJR: A clinical evaluation of Veratrum viride in the treatment of essential hypertension, Am. Heart J. 36: 723, 1948. CrossrefMedlineGoogle Scholar6. 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Author, Article, and Disclosure InformationAffiliations: *Received for publication June 1, 1954.From the Cardiovascular Service, Veterans Administration Hospital, Bronx, N. Y. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byThe management of moderately severe hypertension with cryptenamine and rauwolfiaEvaluation of the Methods of Treatment of Essential HypertensionMedikamente, die auf das autonome Nervensystem wirkenMedikamente, die auf das autonome Nervensystem wirken 1 December 1954Volume 41, Issue 6Page: 1211-1224KeywordsAlkaloidsBradycardiaCardiovascular diseasesDrug administrationDrugsGratitudeHypotension ePublished: 1 December 2008 Issue Published: 1 December 1954 PDF downloadLoading ...