Erythropoietin and Erythropoiesis
Authors: Clifford W. Gurney
Journal: Annals of Internal Medicine (1966)

Editorials1 August 1966Erythropoietin and ErythropoiesisCLIFFORD W. GURNEY, M.D.CLIFFORD W. GURNEY, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-65-2-377 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptInvestigations of the mechanism of regulation of red cell production have received their impetus in recent years from the classical experiments of Reissman (1), which clearly established the existence of a humoral erythropoietic factor, and the studies of Jacobson, Plzak, Fried, and Goldwasser (2) and Jacobson, Gurney, and Goldwasser (3), which made available a series of simple, sensitive procedures for its bioassay. In the last 10 years, there has been rapid progress in understanding of the biochemical nature, mechanism of action, and role in both physiological erythropoiesis and abnormal states of red cell formation of erythropoietin, the hormonal regulator of...References1. REISSMANN KR: Studies on the mechanism of erythropoietic stimulation in parabiotic rats during hypoxia. Blood 5: 372, 1950. CrossrefMedlineGoogle Scholar2. JACOBSONPLZAKFRIEDGOLDWASSER LOLWE: Plasma factor(s) influencing red cell production. Nature (London) 177: 1240, 1956. CrossrefMedlineGoogle Scholar3. JACOBSONGURNEYGOLDWASSER LOCWE: The control of erythropoiesis. Advances Intern. Med. 10: 297, 1960. MedlineGoogle Scholar4. GOLDWASSER E: Biochemical control of erythroid cell development, in Current Topics in Developmental Biology, edited by MOSCONA, A. A., MONROY, A. Academic Press, Inc., New York. In press. Google Scholar5. BORSOOKGRAYBIELKEIGHLEYWINDSOR HAGE: Polycythemic response in normal adult rats to a nonprotein plasma extract from anemic rabbits. Blood 9: 734, 1954. CrossrefMedlineGoogle Scholar6. SLAUNWHITEMIRANDPRENTICE WREATC: Probable polypeptidic nature of erythropoietin. Proc. Soc. Exp. Biol. Med. 96: 616, 1957. CrossrefMedlineGoogle Scholar7. LOWYKEIGHLEYBORSOOK PHGH: Inactivation of erythropoietin by neuraminidase and by mild substitution reactions. Nature (London) 185: 102, 1960. CrossrefMedlineGoogle Scholar8. CONTRERAGORDON JTAS: Erythropoietin: production by a particulate fraction of rat kidney. Science 152: 653, 1966. CrossrefMedlineGoogle Scholar9. FILMANOWICZGURNEY ECW: Studies on erythropoiesis. XVI. Response to a single dose of erythropoietin in the polycythemic mouse. J. Lab. Clin. Med. 57: 65, 1961. MedlineGoogle Scholar10. RAMBACHALTCOOPER WAHAJA: The mode of action and nature of a heat stable plasma erythropoietic factor. Blood 12: 1101, 1957. CrossrefMedlineGoogle Scholar11. FISCHER S: Studies on the mechanism and site of action of erythropoietin, in Erythropoiesis, edited by JACOBSON, L. O. DOYLE, M. Grune & Stratton, New York, 1962, p. 204. Google Scholar12. KRANTZGALLIEN-LARTIGUEGOLDWASSER SBOE: The effect of erythropoietin upon heme synthesis by marrow cells in vitro. J. Biol. Chem. 238: 4085, 1963. CrossrefMedlineGoogle Scholar13. DUKESTAKAKUGOLDWASSER PPFE: In vitro studies on the effect of erythropoietin on glucosamine-1-14C incorporation into rat bone marrow cells. Endocrinology 74: 960, 1964. CrossrefMedlineGoogle Scholar14. KRANTZGOLDWASSER SBE: On the mechanism of erythropoietin-induced differentiation. II. The effect on RNA synthesis. Biochim. Biophys. Acta 103: 325, 1965. CrossrefMedlineGoogle Scholar15. FINNE PH: Erythropoietin in concentrates of urine from healthy persons. Brit. Med. J. 1: 697, 1965. CrossrefMedlineGoogle Scholar16. SCHOOLEYGARCIA JCJF: Immunologic studies on the mechanism of action of erythropoietin. Proc. Soc. Exp. Biol. Med. 110: 636, 1962. CrossrefMedlineGoogle Scholar17. GURNEYJACOBSONGOLDWASSER CWLOE: The physiologic and clinical significance of erythropoietin. Ann. Intern. Med. 49: 363, 1958. LinkGoogle Scholar18. GOLDWASSERJACOBSONFRIEDPLZAK ELOWLF: Studies on erythropoiesis. Effect of cobalt on the production of erythropoietin. Blood 13: 55, 1958. CrossrefMedlineGoogle Scholar19. WINTROBEGRINSTEINDUBACHHUMPHREYSASHENBRUCKERWORTH MMMGCSRHW: Anemia of infection; influence of cobalt on anemia associated with inflammation. Blood 2: 323, 1947. CrossrefMedlineGoogle Scholar20. GUTNISKYVAN DYKE AD: Normal response to erythropoietin or hypoxia in rats made anemic with turpentine abscess. Proc. Soc. Exp. Biol. Med. 112: 75, 1963. CrossrefMedlineGoogle Scholar21. KENNEDYNATHANSONTIBBETTSAUB BJITDMJC: Biochemical alterations during steroid hormone therapy of advanced breast cancer. Amer. J. Med. 19: 337, 1955. CrossrefMedlineGoogle Scholar22. GARDNERPRINGLE FHJC: Androgens and erythropoiesis. II. Treatment of myeloid metaplasia. New Eng. J. Med. 264: 103, 1961. CrossrefMedlineGoogle Scholar23. SHAHIDIDIAMOND NTLK: Testosterone-induced remission in aplastic anemia of both acquired and congenital types. Further observations in 24 cases. Ibid., p. 953, 1961. Google Scholar24. FRIEDDEGOWINGURNEY WRCW: Erythropoietic effect of testosterone in the polycythemic mouse. Proc. Soc. Exp. Biol. Med. 117: 839, 1964. CrossrefMedlineGoogle Scholar25. NAETSWITTEK JPM:Étude du mécanisme d'action des androgènes sur l'érythropoièse. C. R. 259: 3371, 1964. Google Scholar26. MIRANDGORDONWENIG EAASJ: Mechanism of testosterone action in erythropoiesis. Nature (London) 206: 270, 1965. CrossrefMedlineGoogle Scholar27. JANDAFRIEDGURNEY WEWCW: Combined effect of cobalt and testosterone on erythropoiesis. Proc. Soc. Exp. Biol. Med. 120: 443, 1965. CrossrefMedlineGoogle Scholar28. DEGOWINGURNEY RLCW: Hemopoiesis in polycythemia vera after phlebotomy and iron therapy. Arch. Intern. Med. (Chicago) 114: 424, 1964. CrossrefMedlineGoogle Scholar29. GURNEY CW: Polycythemia vera and some possible pathogenetic mechanisms. Ann. Rev. Med. 16: 169, 1965. CrossrefMedlineGoogle Scholar30. ADAMSONFINCH JWCA: Mechanisms of erythroid marrow activation. Trans. Ass, Amer. Physicians. In press, 1966. MedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Argonne Cancer Research Hospital * Departments of Medicine and Physiology The University of Chicago Chicago, Ill.*Operated by the University of Chicago for the United States Atomic Energy Commission. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byErythropoietinUntersuchungen der Erythropoetinaktivität und zur Frage eines Erythropoetininhibitors in Plasmakonzentraten von Patienten mit Polycythaemia veraCurrent Status of ErythropoietinPhysiologic and Pathophysiologic Effects of AnemiaAN ANALYSIS OF HYPOPLASTIC ANAEMIA WITH SPECIAL REFERENCE TO THE USE OF OXYMETHOLONE (”ADROYD“) IN ITS THERAPYErythropoietin 1 August 1966Volume 65, Issue 2Page: 377-381KeywordsBioassays and physiological analysisErythropoiesisErythropoietin Issue Published: 1 August 1966 PDF downloadLoading ...