THROMBOTIC THROMBOCYTOPENIC PURPURA (MOSCHCOWITZ'S DISEASE): REPORT OF A CASE WITH REMISSION AFTER SPLENECTOMY AND STEROID THERAPY
Authors: H D SHAPIRO, D DOKTOR, J CHURG
Journal: Annals of Internal Medicine (1957)

Case Reports1 September 1957THROMBOTIC THROMBOCYTOPENIC PURPURA (MOSCHCOWITZ'S DISEASE): REPORT OF A CASE WITH REMISSION AFTER SPLENECTOMY AND STEROID THERAPYHENRY D. SHAPIRO, M.D., DAVID DOKTOR, M.D., JACOB CHURG, M.D.HENRY D. SHAPIRO, M.D.Search for more papers by this author, DAVID DOKTOR, M.D.Search for more papers by this author, JACOB CHURG, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-47-3-582 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptCases of thrombotic thrombocytopenic purpura have been rare from the time of Moschcowitz's original description in 19251up to the recent past. In a recent review Clough2cites 24 cases to 1950, and the literature to date now totals approximately 60. Even more rare has been the diagnosis in vivo of this syndrome; we have been able to find only six reports.3, 4, 5, 6, 7, 8Yet the combination of hemolytic anemia and thrombocytopenic purpura with variable and transient neurologic symptoms should specifically suggest the diagnosis. We wish to report another antemortem diagnosis and the second well documented case...Bibliography1. Moschcowitz E: An acute febrile pleichromic anemia with hyaline thrombosis of the terminal arterioles and capillaries. An undescribed disease, Arch. Int. Med. 36: 89, 1925. CrossrefGoogle Scholar2. Clough PW: Thrombotic thrombocytopenic purpura, Ann. Int. Med. 33: 739, 1950. LinkGoogle Scholar3. EngelScheinkerHumphrey GLIMDC: Acute febrile anemia and thrombocytopenic purpura with vasothromboses, Ann. Int. Med. 26: 919, 1947. LinkGoogle Scholar4. SingerMotulskyShanberger KAGJN: Thrombotic thrombocytopenic purpura. Two studies in hemolytic syndromes in this disease, Blood 5: 434, 1950. CrossrefMedlineGoogle Scholar5. MeachamOrbisonHeinleSteeleSchaefer GCJLRWHJJA: Thrombotic thrombocytopenic purpura. A disseminated disease, Blood 6: 706, 1951. CrossrefMedlineGoogle Scholar6. BlackmanCohenWatson NSBMJ: Thrombotic thrombocytopenic purpura, J. A. M. A. 148: 546, 1952. CrossrefMedlineGoogle Scholar7. CooperStickneyPeaseBennet TJMGLWA: Thrombotic thrombocytopenic purpura, Am. J. Med. 13: 375, 1952. CrossrefGoogle Scholar8. GreenGreen WSTW: Thrombotic thrombocytopenic purpura, Ann. Int. Med. 39: 371, 1953. LinkGoogle Scholar9. March HW: The diffuse vascular lesion of so called thrombotic thrombocytopenic purpura, Circulation 10: 43, 1954. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: HENRY D. SHAPIRO, M.D.; DAVID DOKTOR, M.D.; JACOB CHURG, M.D.Affiliations: Paterson, New Jersey*Received for publication April 5, 1956.From the Laboratories and the Surgical Service, Barnert Memorial Hospital, Paterson, New Jersey.With the technical assistance of HAZEL C. DE PREE, B.S.Requests for reprints should be addressed to Henry D. Shapiro, M.D., 284 East Thirty-second Street, Paterson 4, New Jersey. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byNovel therapies in thrombotic thrombocytopenic purpuraOutcomes in the treatment of thrombotic thrombocytopenic purpura with splenectomy: A retrospective cohort studyThrombotic thrombocytopenic purpura: Indications for and results of splenectomyThrombotic thrombocytopenic purpura: Recovery after splenectomy associated with persistence of abnormally large von willebrand factor multimersSimilarities and Differences between the Hemolytic Uremic Syndrome and Thrombotic Thrombocytopenic PurpuraSplenectomy for hematologic disordersBIBLIOGRAPHYThrombotic thrombocytopenic purpura in siblingsThrombotic Thrombocytopenic Purpura Serial Clotting Studies, Relation to the Generalized Shwartzman Reaction, and Remission After Adrenal Steroid and Dextran TherapyROBERT G. LERNER, M.D., SAMUEL I. RAPAPORT, M.D., F.A.C.P., JAMES MELTZER, M.D.Indikationen zur Splenektomie bei BlutkrankheitenThrombotic thrombocytopenic purpura in pregnancyThrombotic thrombocytopenic purpuraTHROMBOTIC THROMBOCYTOPENIC PURPURAThrombotic thrombocytopenic purpura of long durationCase 45121Thrombotic Thrombocytopenic Purpura as A Cause of Massive Gastrointestinal Hemorrhage 1 September 1957Volume 47, Issue 3 Page: 582-585 Keywords Hemolytic anemia Splenectomy Steroid therapy Thrombotic thrombocytopenic purpura ePublished: 1 December 2008 Issue Published: 1 September 1957 PDF downloadLoading ...