CLINICAL EVALUATION OF DISODIUM SUCCINATE, INCLUDING A REPORT ON ITS INEFFECTIVENESS IN TWO CASES OF SEVERE BARBITURATE POISONING AND SOME TOXICOLOGIC NOTES ON OTHER SUCCINATE SALTS
Authors: M ZUCKERBROD, I GRAEF
Journal: Annals of Internal Medicine (1950)

Article1 May 1950CLINICAL EVALUATION OF DISODIUM SUCCINATE, INCLUDING A REPORT ON ITS INEFFECTIVENESS IN TWO CASES OF SEVERE BARBITURATE POISONING AND SOME TOXICOLOGIC NOTES ON OTHER SUCCINATE SALTSMORRIS ZUCKERBROD, M.D., IRVING GRAEF, M.D.MORRIS ZUCKERBROD, M.D.Search for more papers by this author, IRVING GRAEF, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-32-5-905 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe significance of succinic acid in biologic oxidation and reduction is not fully understood. That it may be important is indicated by the fact that most normal tissues contain succinic dehydrogenase, which is very active and can account for the rapid oxidation of substrate amounts of succinate in tissue slices in vitro.1 Furthermore, the presence of succinate in the Krebs cycle can explain its rôle as a catalyst in the oxidation of carbohydrates and fats by certain tissue homogenates in vitro.2 The following scheme of relationships is generally accepted3:In 1939, Quastel,4investigating the mode of action of barbiturates, found...Bibliography1. Elliot KA: Intermediary metabolites and respiratory catalysis, Physiol. Rev. 21: 267-306, 1941. CrossrefGoogle Scholar2. Krebs HA: The intermediary stages in the biological oxidation of carbohydrate, Advances in Enzymology 3: 191-252, 1943. Google Scholar3. Potter VR: Biological energy transformations and the cancer problem, Advances in Enzymology 4: 201-256, 1944. Google Scholar4. Quastel JH: Respiration in the central nervous system, Physiol. Rev. 19: 135-183, 1939. CrossrefGoogle Scholar5. SoskinTaubenhaus SM: Sodium succinate as an analeptic for barbiturate poisoning and in the control of the duration of barbiturate anesthesia, J. Pharmacol. and Exper. Therap. 78: 49-55, 1943. Google Scholar6. Barrett RH: The analeptic effect of sodium succinate on barbiturate depression in man, Current Research in Anesthesía and Analgesia 26: 74-81, 105-113, 1947. MedlineGoogle Scholar7. PinschmidtRamseyHaag NWRHHB: Studies on the antagonism of sodium succinate to barbiturate depression, J. Pharmacol. and Exper. Therap. 23: 45-52, 1945. Google Scholar8. BeyerLatven KHAR: An evaluation of the influence of succinate and malanate on barbiturate anesthesia, J. Pharmacol. and Exper. Therap. 21: 203-208, 1944. Google Scholar9. LardyHansenPhillips HARCPH: Ineffectiveness of sodium succinate in the control of duration of barbiturate anesthesia, Proc. Soc. Exper. Biol. and Med. 55: 277-278, 1944. CrossrefGoogle Scholar10. CorsonKoppanyiVivino SATAE: Effect of succinate and fumarate in experimental barbiturate poisoning, Current Research in Anesthesia and Analgesia 24: 177-191, 1945. Google Scholar11. Shorr E: Treatment of barbiturate poisoning, Am. J. Med. 1: 93-103, 1946. MedlineGoogle Scholar12. Proger S: The use of respiratory catalysts, particularly succinic acid, in tissue anoxia, Bull. New England M. Center 5: 80-85, 1943. Google Scholar13. FurchgottShorr RFE: The effect of succinate on respiration and certain metabolic processes of mammalian tissues at low oxygen tensions in vitro, J. Biol. Chem. 175: 201-215, 1948. CrossrefMedlineGoogle Scholar14. Master AM: The electrocardiogram after exercise—a standardized heart function test, U. S. Naval M. Bull. 40: 346-351, 1942. Google Scholar15. Christensen BC: Electrocardiographic changes in man during voluntary hyperventilation, J. Clin. Investigation 25: 880-889, 1946. CrossrefGoogle Scholar16. BestTaylor CHNB: Physiological basis of medical practice, p. 17, Third Edition. Google Scholar17. DwyerKronenbergSaklad CSSM: Anginal syndrome during sodium succinate therapy, Ann. Int. Med. 31: 148-153, 1949. LinkGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: *Received for publication September 15, 1949.From the Third (New York University) Medical Division, Goldwater Memorial Hospital, Welfare Island, New York and the Department of Medicine, College of Medicine of the New York University-Bellevue Medical Center, 477 First Avenue, New York, N. Y.The drugs were furnished and the work supported by a grant from Brewer & Company, Inc., Worcester, Massachusetts. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byInsight into SUCNR1 (GPR91) structure and functionElectrographic monitoring of anaesthesia*ACUTE BARBITURATE INTOXICATION: A STUDY OF 300 CASES BASED ON A PHYSIOLOGIC SYSTEM OF CLASSIFICATION OF THE SEVERITY OF THE INTOXICATION*CHARLES E. REED, M.D., MARSHALL F. DRIGGS, M.D., F.A.C.P., CHARLES C. FOOTE, M.D. 1 May 1950Volume 32, Issue 5Page: 905-916KeywordsBiologicsCarbohydratesDehydrogenasesDrugsFatsHospital medicineSaltsToxicity ePublished: 1 December 2008 Issue Published: 1 May 1950 PDF downloadLoading ...