tbuckley/cabot-search huggingface dataset:
Risk Management Report Issued
Authors: Stuart L. Nightingale
Journal: JAMA (1999)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
466. Downregulation of ATF2 Desensitizes Oral Squamous Cell Carcinoma to Apoptosis
Authors: Sleiman N. Razzouk, Svetlana M. Dolgilevich, Dianne C. Duffey
Journal: Molecular Therapy (2004)

Introduction: Oral squamous cell carcinomas (OSCC) are aggressive cancer types because of their invasiveness,ability to metastasize locoregionally, and relative resistance to nonsurgical therapies. Transcription factors are molecular targets with known importance in mechanisms of tumorigenesis of OSCC. For example, the transcription factors NF-kB and AP-1 are upregulated in OSCC in a constitutive fashion. This activation correlates functionally with the production of pro-inflammatory cytokines that enhance angiogenesis, mitogenesis, and invasion. ATF2 has been implicated in the regulation of genes that play roles in apoptosis, survival and tumor progression in other cell systems. It also partners with many transcription factors such as c-Jun to initiate transcriptional activity. Recently, ATF2 has also been identified as an executor of apoptosis in poorly differentiated tumor cells. Here we demonstrate that ATF2 can be downregulated in OSCC using siRNA. We also show that decreasing ATF2 in the human oral tongue carcinoma cell line UMSCC 9 affects resistance of cells to staurosporin-mediated growth inhibition.
Abstract 57: Increased Fitness Attenuates the Risk for Developing Atrial Fibrillation in African-Americans
Authors: Charles Faselis, Peter Kokkinos, John Peter Kokkinos, Apostolos Tsimploulis, Fiorina Kyritsi, Andreas Pittaras, Michael Doumas, Hans Moore, Pamela Karasik, Ross Fletcher
Journal: Circulation (2014)

Introduction: Atrial fibrillation (AF) is associated with increased mortality risk. Some studies indicate that endurance training may increase the rate of progression to AF. However, others dispute this notion. Furthermore, fitness status and atrial fibrillation in African-Americans has not been investigated. Methods: From 1986 to 2011, a total of 4,401 African-Americans with normal sinus rhythm (mean age 56±11) underwent a routine exercise tolerance testing at Veterans Affairs Medical Centers Washington DC. During a mean follow-up period of 8.0±4.7 years 361 (8.2%) developed AF. To assess the role of fitness status in the development of AF, we formed the following four fitness categories based on peak workload achieved (metabolic equivalents; METs): Least-Fit: ≤ 5METs (≤20%; n=531); Low-Fit: 5.5-7.2 METs (20.1%-50%; n=1,367); Moderate-Fit:7.3-9.0 METs (50.1%-80%; n=1,775); and High-Fit: &gt;9 METs (&gt;80%; n=728). Cox proportional hazards models were applied after adjusting for age, BMI, race, gender, CV disease, CV medications, and cardiac risk factors. P-values &lt;0.05 using two sided tests were considered statistically significant. Results: The association between exercise capacity and the risk for developing AF was inverse and graded. For every 1-MET increase in exercise capacity the AF-risk was 25% lower (HR=0.75; CI: 0.71-0.81; p&lt;0.001). When compared to the Least-Fit category, the risk for developing AF was 36% lower (HR=0.64; CI: 0.48-0.83; p=0.001) in Low-Fit; 66% (HR=0.44; CI: 0.33-0.60; p&lt;0.001) in Moderate-Fit; and 76% (HR=0.24; CI: 0.14-0.40; p&lt;0.001) in High-Fit individuals. Conclusions: Aerobic fitness is inversely and independently associated with lower risk for developing AF.
Changes in exhaled volatile organic compound profile after breakfast: Implications for protocol development
Authors: Kerry Anderson, Jason Skinner, Caroline Beardsmore, Timothy Coats, Hitesh Pandya
Journal: European Respiratory Journal (2014)

Analysis of Volatile Organic Compounds in Exhaled Breath (eVOCs) is a non-invasive diagnostic tool that has been used to identify patients with diseases including pseudomonas infection and lung cancer (Robroeks CM et al, Ped Res 2010; 68:75, Phillips M et al Lancet 1999; 353,9168,1930). These eVOC profiles have been measured off-line, but on-line measurements providing data in real-time are now feasible. As there is little known about which patient-related factors affect eVOC profiles, and no standard protocol for on-line measurements, we tested the hypothesis that eating does not alter eVOC profiles.  Breath samples were collected from 9 healthy adult volunteers in the Emergency Department of Leicester Royal Infirmary. We used breath sampling equipment attached to a PTR-ToF-Mass Spectrometer to measure ion counts in mass channels 0 to 300 from 80 seconds of tidal breathing and in background air. Breath samples were collected in the starved state, immediately after eating, after 15 minutes and 1 hour.  In every volunteer, ion counts were measurable in mass channels 15 to 249 (234/300). After subtracting background counts, there were no significant differences in 207/234 mass channels before and immediately after breakfast. Ion counts were significantly higher in 9/234 and significantly lower in 17/234 mass channels (p  Our data indicate that time since last meal confounds interpretation of eVOC profiles. Food ingestion should be considered when analysing eVOC data to detect or monitor airway diseases.
Studies on Transplantable Testicular Teratomas of Strain 129 Mice2
Authors: Leroy C. Stevens
Journal: JNCI Journal of the National Cancer Institute (1958)

Journal Article Studies on Transplantable Testicular Teratomas of Strain 129 Mice Get access Leroy C. Stevens Leroy C. Stevens Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 20, Issue 6, June 1958, Pages 1257–1275, https://doi.org/10.1093/jnci/20.6.1257 Published: 01 June 1958 Article history Received: 22 January 1958 Published: 01 June 1958
Air pollutants and the admission rate of psychiatric patients
Authors: M Strahilevitz, A Strahilevitz, J E Miller
Journal: American Journal of Psychiatry (1979)

The authors studied the correlation between mean daily levels of several air pollutants and the number of emergency room visits and inpatient admissions to a psychiatric hospital in St. Louis during one summer and fall. Nitrogen dioxide and carbon monoxide showed a positive correlation with emergency room visits by all patients, and nitrogen dioxide also had a positive correlation with inpatient admissions of subjects with diagnoses that were unknown or could not be specified as psychotic. Nitrogen monoxide showed a negative correlation with inpatient admissions during working days (but not during weekends and holidays) for all patients, as well as for those with diagnoses that were unknown or could not be specified as psychotic.
Pseudomonas syringae pv. tomato DC3000 Type III Secretion Effector Polymutants Reveal an Interplay between HopAD1 and AvrPtoB
Authors: Hai-Lei Wei, Suma Chakravarthy, Johannes Mathieu, Tyler C. Helmann, Paul Stodghill, Bryan Swingle, Gregory B. Martin, Alan Collmer
Journal: Cell Host & Microbe (2015)
468. Tissue Factor as a Link between Wounding and Tissue Repair
Authors: Jiang Chen, Michael Kasper, Katsumi Nakagawa, Lin Bai, Wu Gang, Youming Zhang, Per M. Humpert, Martin Andrassy, Thomas Luther, Stephan Schiekofer, Baosheng Chen, Michael Morcos, Andreas Hamann, David M. Stern, Peter P. Nawroth, Angelika Bierhaus
Journal: Molecular Therapy (2004)

Top of pageAbstract
Delayed healing of cutaneous wounds in diabetes is associated with reduced vascular endothelial growth factor (VEGF) expression and impaired recruitment of smooth muscle cells. Consistent with the concept that low levels of tissue factor (TF) might be associated with diminished VEGF expression, we explore skin wound healing, in which decreased cell proliferation and angiogenesis might be explained by a relative impairment in local TF induction. NOD mice were used in the experiments. Skin wounds were generated at both sides of the lower dorsal trunk. Local somatic gene transfer of TF was achieved by liposomal mediated transfection. Wound and wound samples were evaluated at designated time point for size, gene expression pattern and blood vessel and flow. In diabetes, TF induction in response to cutaneous wounding which ordinarily precedes increased expression of VEGF and a-smooth muscle actin (SMA) transcription, is diminished. Enhanced TF expression in wounds of diabetic mice increased VEGF transcription and translation, and enhanced formation of new blood vessels and elevated blood flow. Increased levels of TF in wounds of diabetic mice enhanced wound healing. The time to achieve 50% wound closure was reduced from 5.5 days in untreated diabetic mice to 4.1 days in animals undergoing TF gene transfer. Cutaneous wounds in diabetic mice display a relative deficiency of TF, thereafter, contributes to delayed wound repair. These data establish TF expression as an important link between the early inflammatory response to cutaneous wounding and reparative processes.
Small Loans Yield Big Health Profits
Authors: Brian Vastag
Journal: JAMA (2004)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Abstract 578: RARRES1 is a tumor suppressor in triple-negative breast cancer cell lines
Authors: Krysta M. Coyle, Ahmad Vaghar-Kashani, Florence Wong, Cheryl Dean, Carman Giacomantonio, Paola Marcato
Journal: Cancer Research (2014)

Abstract Increasing evidence suggests that retinoic acid (RA) signaling is of great importance in the progression and metastasis of different cancer types. We have previously reported that MDA-MB-231 and MDA-MB-468 triple-negative breast cancer cell lines display different responses to increased retinoic acid: retinoic acid increases MDA-MB-231 xenograft growth and decreases growth MDA-MB-468 xenografts. To investigate what may be responsible for these opposite responses to RA, we have investigated the role of retinoic acid receptor responder protein 1 (RARRES1). RARRES1 is an RA-inducible gene which has not yet been fully characterized. Despite its unknown function, many independent studies have reported the tumor suppressive function of RARRES1 in multiple cancer types. Interestingly, our previous data indicates that high levels of RARRES1 in clinical breast cancer samples is correlated with poorer outcomes for patients. In particular, high expression of RARRES1 is associated with triple-negative breast cancers as well as with more aggressive cancers (by Ki67 positivity, as well as nuclear, mitotic, and overall grade). Thus, to determine the role of RARRES1 in breast cancers, we have performed in vitro cell proliferation and in vivo xenograft assays. We report that knockdown of RARRES1 in MDA-MB-231 and MDA-MB-468 cells leads to increased cell proliferation in vitro and in in vivo xenografts. RARRES1 is proposed to regulate a number of genes, including the hypothesized tumor suppressors discs large homolog 2 and protein phosphatase 2A, the proto-oncogene valosin-containing protein (p97), and ankyrin repeat domain-containing protein 26 which is of unknown function. We are investigating the regulation of these genes by RARRES1 in MDA-MB-231 and MDA-MB-468 triple-negative cell lines. We expect that the RARRES1 tumor suppressor is one of many genes induced by RA which form a complex signaling pathway regulating the response of cells to RA. We conclude that RARRES1 is a tumor suppressor in MDA-MB-231 and MDA-MB-468 triple-negative breast cancer cell lines; however, we continue to investigate the discrepancy between this finding and our previous clinical data. Citation Format: Krysta M. Coyle, Ahmad Vaghar-Kashani, Florence Wong, Cheryl Dean, Carman Giacomantonio, Paola Marcato. RARRES1 is a tumor suppressor in triple-negative breast cancer cell lines. [abstract]. In: Proceedings of the 105th Annual Meeting of the American Association for Cancer Research; 2014 Apr 5-9; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2014;74(19 Suppl):Abstract nr 578. doi:10.1158/1538-7445.AM2014-578
Abstract 14859: IL17 Contribute to the Atherosclerotic Development and the Initiation of Chronic Kidney Disease
Authors: Yusuke Tanigaito, Kayoko Sato, Kazutaka Kitamura, Atsuko Futase, Keiko Fukushima, Kenta Uto, Nobuhisa Hagiwara
Journal: Circulation (2014)

Introduction: Recent studies suggested that the atherogenic state correlated with progression of chronic kidney disease (CKD). However, it is not known whether sustained status of chronic inflammation in atherosclerosis is closely linked to the development of CKD. Hypothesis: Inflammatory cytokine producing-T cells in the advanced atherosclerosis induced the dysfunction of podocytes. Methods/Results: Eighteen-week-old apolipoprotein E-deficient mice (Control) were fed with high-fat diet for 8W (ApoE) and compared to IL17/ApoE-double deficient mice fed with high-fat diet (DKO). Sudan staining of aorta revealed the atherosclerotic lesion was increased in ApoE compared to Control, and inhibited in DKO. Activated IFNγ + CD4 T cells (Th1) and IL17 + CD4 T cells (Th17) were significantly increased in ApoE compared to DKO by FACS. Immunohistochemistry of aortic sinus showed many Th1 and Th17 were infiltrated in the atherosclerotic plaque in ApoE, however, inflammatory infiltrates were inhibited in DKO. Furthermore, the urinary albumin/creatinine ratio was increased significantly in ApoE compared to DKO. Th1 and Th17 were correlated with the urinary albumin/creatinine ratio, and many Th1 and Th17 were observed in the glomeruli. Next, to investigate whether the inflammatory cytokine induced dysfunction of podocytes were involved in proteinuria, we investigated nephrin, podocin, and phosphorylated nephrin in the kidney by Western blots and immunohistochemistry. The decreased phosphorylated neprin in ApoE were recovered in DKO. Finally, we confirmed that the morphological changed of podocytes in ApoE were improved in DKO by electron microscopy. Conclusion: Recruitments of IFNγ + Th1 and IL17 + Th17 T cells might aggravate atherosclerosis acceleration and induce the initiation of glomerular tissue damage.
Classification of Psychiatric Disorders
Authors: Robert L. Spitzer, Michael B. First
Journal: JAMA (2005)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Abstract 17554: A Unique Synergistic Approach That Uncovers MLC2v Phosphorylation as an Early Marker for Heart Disease
Authors: Farah Sheikh, Kunfu Ouyang, Stuart Campbell, Robert C Lyon, Joyce Chuang, Dan Fitzsimons, Hongqiang Cheng, Yusu Gu, Nancy Dalton, Hideko Kasahara, Majid Ghassemian, Jeffrey H Omens, Richard L Moss, Kirk L Peterson, Andrew D McCulloch, Ju Chen
Journal: Circulation (2010)

Currently it is understood that the major proteins that activate heart muscle contraction during each heartbeat are from the calcium-dependent actin regulatory family. In contrast, myosin regulator...
STUDIES ON THE VELOCITY OF BLOOD FLOW
Authors: Herrmann L. Blumgart, Soma Weiss
Journal: Journal of Clinical Investigation (1927)

The velocity at which blood flows is of considerable consequence in maintaining physiological well being.As has been pointed out in a preceding communication, it is not sufficient that an adequate amount of blood be expelled from the heart per minute; it is of primary importance that this blood be conveyed to the depots of utilization with the proper dispatch, and that it flow through the capillaries at suffi- -cient speed to allow the proper interchange between blood and tissues.It may be contended that whether an adequate volume of blood reaches the tissues through narrow arteries at a great velocity, or through large arteries at a lesser velocity is-not of primary importance.A given amount of blood ejected from the heart which might be entirely adequate if supplied through narrow vessels at a high velocity might, however, be inadequate if transported at a low velocity through wide vessels.We believe, therefore, that both the minute volume output and the velocity of blood f ow are indices of two fundamental aspects of the circulation, aspects that are closely related, and which must both be satisfactory if the propet supply of blood to the tissues is to be maintained.The relationship between volume flow and ve*locity flow through tubes of known diameter is a simple one and is expressed by the equation V =-where V = velocity expressed in seconds, A = irr2 volume per second, and r is the radias of the tube.It is evi-
Diseases of the Skin. A Manual for Students and Practitioners.
Authors: Robert William MacKenna
Journal: JAMA (1923)

The most impressive features of this new book are the excellent clinical illustrations, the colored plates and the clear and concise presentation of the subject matter. The book is well assembled and contains an excellent index and an appendix. There are twenty-six chapters. The material is conveniently divided into three parts, concerning (1) diseases of known etiology; (2) those clinically similar, and (3) those affecting certain structures, for example, diseases of the hair. The life history of Sarcoptes scabiei is new material and is accurately related. Many new diseases are not described. Even Kaposi's sarcoma is omitted. On the whole, the textbook is elementary and therefore suitable for medical students and general practitioners. For these two groups the author has taken pains to describe differential diagnosis fully. As a further aid to the student, excellent tables have been prepared, which enable the reader to separate one condition from another. The
Abstract 352: Integrating transcriptomic data using metacore pathway analysis to identify novel biomarkers of bevacizumab target engagement
Authors: Chris D. Willis, Kyle Lafferty-Whyte, Melinda Baker, Richard G. Pestell
Journal: Cancer Research (2014)

Abstract The widespread use of microarrays for gene expression studies has generated large volumes of transcriptomic data to help describe mechanisms such as drug treatment response. The drug Bevacizumab is well characterized for its ability to inhibit VEGFA pro-angiogenic signaling resulting in tumor regression for a number of cancer-related indications. However, universal mechanisms of action have remained elusive to describe changes at the mRNA level across different solid tumor types. This case study uses 3 publically available datasets related to Bevacizumab treatment and analyzes the data in a manually curated systems biology context. Using a combination of Thomson Reuters solutions including the Data Annotation and Processing tool, MetaCore Pathway Analysis and Integrity Biomarkers Module allows for a simple workflow to process omics data and identify biomarkers of target engagement through pathway analysis and data integration. This analysis identified 5 differentially expressed genes common to all treated tumors including: Basonuclin, growth arrest-specific 7, mucin 1, integrin beta-4, and dystonin. All 5 of these objects can be connected to VEGF-A in a signaling network based on previously curated interactions. These in silico results provide a strong rationale for follow up studies in the lab to validate novel biomarkers related to Bevacizumab target engagement in solid tumors. Citation Format: Chris D. Willis, Kyle Lafferty-Whyte, Melinda Baker, Richard G. Pestell. Integrating transcriptomic data using metacore pathway analysis to identify novel biomarkers of bevacizumab target engagement. [abstract]. In: Proceedings of the 105th Annual Meeting of the American Association for Cancer Research; 2014 Apr 5-9; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2014;74(19 Suppl):Abstract nr 352. doi:10.1158/1538-7445.AM2014-352