tbuckley/cabot-search huggingface dataset:
MeIQx regulates bcl-3 expression in human-derived hepatocellular carcinoma cells
Authors: Fallou Diouf, Kimberlee Bizzell, Minnie Holmes-McNary
Journal: Cancer Research (2008)

4373   Hepatocellular carcinoma (HCC) is considered a solid tumor and is one of the ten most common human carcinomas in the world. Nuclear factor kappaB (NF-kappaB) is well described as a potent transcription factor that is involved in immunity and cancer cell survival. However, abnormal activation of NF-kappaB is linked with many types of diseases, including HCC. A recent study by Cusack and colleagues (2003) has shown that solid tumors expressing NF-kappaB can resist cell death.  There are several risk factors for HCC including diabetes, smoking, chronic hepatitis B virus (HBV), alcoholism, aflatoxin, obesity and dietary carcinogen consumption. Our interest is in the dietary carcinogen 2-amino-3,8-dimethylimidazole [4,5,] quinoxaline (MeIQx). Previously our studies have shown that MeIQx can induce NF-kappaB in HepG2 cells. Since many studies have shown expression of the NF-kappaB regulated gene Bcl-3, we hypothesize that MeIQx can regulate the expression of Bcl-3 in hepatocellular carcinoma (HepG2) cells. We examined the effect of MeIQx exposure on Bcl-3 expression in HepG2 cells. Our studies indicate that MeIQx exposure regulated Bcl-3 expression in HepG2 cells in a time-dependent manner. These results support a model where HepG2 cells that are MeIQx stimulated can lead to cell death resistance and therefore cell survival. Supported in part by a Faculty Grant, Department of Biological Sciences,College of Arts and Sciences, NCAT State University(MHM), and Ohio Agricultural Research Development Center (OARDC, Seed grant),HATCH grant(USDA)(MHM).
Bendamustine in Combination with Rituximab for Previously Untreated Chronic Lymphocytic Leukemia (CLL) Patients: An Italian Retrospective Multicentre Study
Authors: Massimo Gentile, Stefania Ciolli, Stefano Molica, Nicola Di Renzo, Carmine Selleri, Maria Rosaria Villa, Maria Rosaria De Paolis, Ilaria Scortechini, Angela Giannotta, Carla Minoia, Angela Rago, Riccardo Boncompagni, Vincenza Bonanno, Luciano Levato, Maurizio Musso, Lucia Mastrullo, Angela Melpignano, Roberta Murru, Emanuele Angelucci, Giuseppe Tarantini, Giuseppe Caparrotti, Attilio Guarini, Felicetto Ferrara, Giuseppe Cimino, Pier Luigi Zinzani, Fortunato Morabito
Journal: Blood (2014)
Targeting TRAF3 signaling protects against hepatic ischemia/reperfusions injury
Authors: Junfei Hu, Xue-Hai Zhu, Xiao-Jing Zhang, Pi-Xiao Wang, Ran Zhang, Peng Zhang, Guang-Nian Zhao, Lu Gao, Xiao-Fei Zhang, Song Tian, Hongliang Li
Journal: Journal of Hepatology (2015)
Detection of influenza A(H1N1)v virus by real-time RT-PCR
Authors: M Panning, M Eickmann, O Landt, M Monazahian, S Ölschläger, S Baumgarte, U Reischl, J J Wenzel, H H Niller, S Günther, B Hollmann, D Huzly, J F Drexler, A Helmer, S Becker, B Matz, A M Eis-Hübinger, C Drosten
Journal: Eurosurveillance (2009)

Influenza A(H1N1)v virus was first identified in April 2009. A novel real-time RT-PCR for influenza A(H1N1)v virus was set up ad hoc and validated following industry-standard criteria. The lower limit of detection of the assay was 384 copies of viral RNA per ml of viral transport medium (95% confidence interval: 273-876 RNA copies/ml). Specificity was 100% as assessed on a panel of reference samples including seasonal human influenza A virus H1N1 and H3N2, highly pathogenic avian influenza A virus H5N1 and porcine influenza A virus H1N1, H1N2 and H3N2 samples. The real-time RT-PCR assay for the influenza A matrix gene recommended in 2007 by the World Health Organization was modified to work under the same reaction conditions as the influenza A(H1N1)v virus-specific test. Both assays were equally sensitive. Clinical applicability of both assays was demonstrated by screening of almost 2,000 suspected influenza (H1N1)v specimens, which included samples from the first cases of pandemic H1N1 influenza imported to Germany. Measuring influenza A(H1N1)v virus concentrations in 144 laboratory-confirmed samples yielded a median of 4.6 log RNA copies/ml. The new methodology proved its principle and might assist public health laboratories in the upcoming influenza pandemic.
Changing outcomes in percutaneous coronary interventions
Authors: Paul D. McGrath, David J. Malenka, David E. Wennberg, Samuel J. Shubrooks, William A. Bradley, John F. Robb, Mirle A. Kellett, Thomas J. Ryan, Michael J. Hearne, Bruce Hettleman, John R. O’Meara, Peter VerLee, Matthew W. Watkins, Winthrop D. Piper, Gerald T. O’Connor
Journal: Journal of the American College of Cardiology (1999)
Abstract 1331: Myocardial Function Alterations Correlate to Cardiac Fibrosis and Upregulation of Profibrotic Signaling in Plasminogen Activator Inhibitor-1 Deficient Mice
Authors: William Bradham, Linda Gleaves, Mousumi Medda, Douglas Vaughan
Journal: Circulation (2007)

Cardiac fibrosis is a common sequelae of cardiac injury and has deleterious functional consequences impacting cardiac filling, function and rhythm. Plasminogen activator inhibitor-1 (PAI-1) has been implicated in the pathogenesis of tissue fibrosis in mice. To investigate the longitudinal effect of PAI-1 on cardiac structure and function, M-mode echocardiography was employed to examine cardiac function in PAI-1 deficient (PAI-1 −/− ) and wild-type (WT) control mice in four age groups (6,12,18, 24 months). Eighteen month old PAI-1 −/− mice exhibited reduced left ventricular (LV) diastolic internal dimension ( p =0.0118) and a trend towards increased LV posterior wall (LVPW) thickness, compared to WT. Two year old PAI-1 −/− mice showed increased diastolic and systolic LVPW thickness ( p =0.0127 and p =0.0212, respectively), reduced diastolic and systolic LV internal dimension ( p =0.0486 and p =0.0124), but with preserved LV fractional shortening compared to WT. Histological examination of cardiac sections revealed fibrosis on the anterior epicardial surface of the hearts in 18 month old PKO, which in 26 month old mice had become confluent with extensive (10 –17% by area) epicardial, perivascular, and interstitial distribution (compared to none in WT). Real time polymerase chain reaction (RT-PCR) revealed upregulation of transforming growth factor beta (TGF-β) and fibroblast growth factor 2 in PAI-1 −/− compared to WT ( p =0.0234 and p =0.037, respectively). Immunofluoresence confirmed this finding with bright TGF-β staining localized in the media of intra-myocardial arterioles, and phosphorylated SMAD2/3, the downstream TGF-β signaling mediator, in areas of fibrosis. Thoracic aortic cells from aged (18 –24 month) PKO and WT mice were grown in culture, with RT-PCR revealing 4 fold increased TGF-β and 17 fold increased SMAD3 ( p &lt;0.05 for both) RNA levels in PAI-1 −/− , supplying additional evidence for upregulation of a profibrotic TGF-β/SMAD tissue signaling pathway. The present study is one of the first to elucidate some of the functional consequences and relevant molecular signaling pathways related to aging and PAI-1 deficiency mediated cardiac fibrosis.
Abstract 3632: Aortic Stiffness and Carotid Intima Media Thickness are Associated with Penile Doppler Findings in Patients with Vasculogenic Erectile Dysfunction
Authors: Charalambos Vlachopoulos, Nikolaos Ioakeimidis, Dorothea Tsekoura, Konstantinos Aznaouridis, Konstantinos Rokkas, Nikolaos Alexopoulos, Gerasimos Siasos, Christodoulos Stefanadis
Journal: Circulation (2006)

Objective: Erectile dysfunction (ED) may be a sign of generalized vascular disease. Intima-media thickness (IMT) and aortic stiffness are markers and prognosticators of cardiovascular risk. The ass...
Abstract 13942: Do Geographic Trends in Aspirin Discharge Dose Alter Outcomes After STEMI and Primary PCI: Results From the HORIZONS-AMI Trial
Authors: Jennifer Yu, George Dangas, Ke Xu, Samantha Sartori, Bimmer Claessen, Martin Fahy, Helen Parise, Alexandra J Lansky, Bernhard Witzenbichler, Cindy L Grines, Giulio Gaugliumi, Ran Kornowski, Jochen Wohrle, Dariusz Dudek, Gregg W Stone, Roxana Mehran
Journal: Circulation (2011)

Background Previous studies have suggested an association between higher aspirin dose and bleeding. We sought to examine the geographic differences in aspirin dosing post STEMI, and to determine an...
Functional Status in Rate- Versus Rhythm-Control Strategies for Atrial Fibrillation
Authors: Mina K. Chung, Lynn Shemanski, David G. Sherman, H. Leon Greene, David B. Hogan, Joyce C. Kellen, Soo G. Kim, Lisa Warsinger Martin, Yves Rosenberg, D. George Wyse
Journal: Journal of the American College of Cardiology (2005)
Autoimmune Hemolysis &amp; Immune Thrombocytopenic Purpura after Cord Blood Transplantation (CBT) May be Life-Threatening &amp; Warrants Early Therapy with Rituximab
Authors: Valkal Bhatt, Leyla Shune, Emily J Lauer, Marissa N Lubin, Sean M. Devlin, Andromachi Scaradavou, Nancy A. Kernan, Sergio Giralt, Rekha Parameswaran, Miguel-Angel Perales, Doris M. Ponce, Gerald A. Soff, Juliet N. Barker
Journal: Blood (2014)
Abstract 1339: Tumor Necrosis Factor Receptor-2 Plays a Critical Role for Induction of Post Ischemic Neovascularization in Mouse Model of Hind Limb Ischemia
Authors: Rajesh G Katare, Yoshihiko Kakinuma, Mikihiko Arikawa, Takemi Handa, Fumiyasu Yamasaki, Takayuki Sato
Journal: Circulation (2007)

Background: Tumor necrosis factor alpha (TNF-α) is expressed in ischemic and necrotic tissue and is known to modulate angiogenesis. However the effect of TNF receptors on angiogenesis is not known....
Educational Intervention to Reduce Outpatient Inappropriate Echocardiograms
Authors: R. Sacha Bhatia, David M. Dudzinski, Rajeev Malhotra, Creagh E. Milford, Danita M. Yoerger Sanborn, Michael H. Picard, Rory B. Weiner
Journal: JACC. Cardiovascular imaging (2014)
Lessons of a hip failure
Authors: P. Riordan, G. Bickler, C. Lyons, W M Harper, K Abrams, R Elson, C. J S Hodges, W.-C. Leung
Journal: BMJ (1998)

Racial discrimination in distinction awards Discrimination is probably indirectEditor-Esmail et al attribute disparity between white and non-white award holders to discrimination. 1 Existence of direct discrimination in some spheres of the NHS does not imply it also affects distinction awards.The regional and central advisory committees on distinction awards are beyond reproach.Rubin's suggestion that several other factors may explain the skewed distributions is more plausible. 2Disparity between groups of consultants is inevitable because of differences in abilities, training, and opportunities.The Commission for Racial Equality held that the criteria laid down for distinction awards could, however, result in indirect discrimination, not necessarily with discriminatory intent.For example, the weight given to work of national and international significance may make the awards less accessible to those in smaller district general hospitals or specialties, where ethnic minority consultants may be concentrated.The Department of Health has therefore issued criteria placing less emphasis on national and international recognition and making A awards available to consultants delivering "outstanding and sustained service to the NHS in an exceptionally hard pressed post" provided it is not the sole ground for an award.Introduced for the 1998 awards round, the criteria are fairer and more widely applicable, but will they change attitudes?Consultants work under varied conditions.However, the criteria do not seem to allow for this.The uniform expectations across the board lead to a skewed distribution of awards with a bias towards academics, consultants in teaching hospitals and larger district general hospitals, and those in the high profile specialties.Esmail et al quite rightly highlight the disparity.Their campaign should, however, be directed towards rectifying the situation which places not only ethnic minority consultants but also many other consultants at a significant disadvantage.Eliminating prejudice in the system, if it exists, is more difficult than establishing a fairer assessment of achievements based on individual circumstances.
Loss Of H3K27 Trimethylation (H3K27me3) Associates With a Multi Drug Resistance Phenotype In Acute Myeloid Leukemia (AML)
Authors: Stefanie Göllner, Tino Schenk, Sven Stengel, Christian Rohde, Tim Sauer, Arthur Zelent, Sigal Tavor, Friedrich Stölzel, Gerhard Ehninger, Gabriele Köhler, Wolfgang E. Berdel, Christian Thiede, Carsten Müller-Tidow
Journal: Blood (2013)
Abstract 13010: Deletion of Tenascin C Attenuates Pressure Overload Induced Cardiac Dilation and Contractile Dysfunction
Authors: Fanny Laroumanie, Christine Delage, Denis Calis, Dounia Abadi, Joffrey Pozzo, Florence Tortosa, Angelo Parini, Nathalie Pizzinat
Journal: Circulation (2012)

Introduction The extracellular matrix protein tenascin C (TnC) is highly expressed during embryogenesis. In adult tissues, TnC is not expressed under physiologic conditions but strongly induced in ...
Safety and Efficacy of Bivalirudin With and Without Glycoprotein IIb/IIIa Inhibitors in Patients With Acute Coronary Syndromes Undergoing Percutaneous Coronary Intervention
Authors: Harvey D. White, E. Magnus Ohman, A. Michael Lincoff, Michel E. Bertrand, Antonio Colombo, Brent T. McLaurin, David A. Cox, Stuart J. Pocock, James A. Ware, Steven V. Manoukian, Alexandra J. Lansky, Roxana Mehran, Jeffrey W. Moses, Gregg W. Stone
Journal: Journal of the American College of Cardiology (2008)
Depression, delusions, and suicide
Authors: S P Roose, A H Glassman, B T Walsh, S Woodring, J Vital-Herne
Journal: American Journal of Psychiatry (1983)

A retrospective analysis of all the suicides at the New York State Psychiatric Institute over a 25-year period was carried out. The authors retrospectively assigned diagnoses according to Research Diagnostic Criteria and DSM-III and found that among the patients who committed suicide there were 14 with unipolar endogenous depression. Of those 14 patients, 10 were considered delusional or probably delusional. In comparison, a control group of similarly diagnosed depressed patients taken from the same institution over the same time period included far fewer delusional depressions. Thus, there was a significant association between delusions and suicide: A delusionally depressed patient was five times more likely to commit suicide than a nondelusional one.
Oral rehydration for children with diarrhea
Authors: F Mota Hernández
Journal: JAMA (1991)

<h3>To the Editor.</h3> —With regard to the problem posed by Meyers et al,<sup>1</sup>it would seem reasonable to have available packets of oral rehydration mixtures (with appropriate directions) to be dispensed at well-baby visits during the rotavirus season. I believe that such packets are being used already in oral rehydration therapy studies in third world countries. They are very inexpensive, but mixing instructions should be quite clear to avoid iatrogenic hypernatremia. I am sure that I am not the only one in this country who was able to successfully use homemade solutions before the development of commercial preparations.
Abstract 2089: Randomized Controlled Trial of the Effects of Lifestyle Modification on Metabolic Coronary Heart Disease Risk Factors
Authors: Eui Geum Oh, So Yeon Bang, Sa Saeng Hyun, Soo Hyun Kim, Yong Kwan Jeon, Jee Aee Im, Mi Kyung Lee, Jung Eun Lee, Sang Hui Chu
Journal: Circulation (2008)

Purpose : This study was to examine the effects of a six-month therapeutic lifestyle modification (TLM) program on metabolic coronary heart disease risk parameters in post menopausal Korean women with metabolic syndrome (Mets). Methods: A randomized controlled design was used. Fifty four women with Mets were randomly assigned to receive a TLM program. The program was a six-month supervised weekly TLM session consisted of health monitoring, education, aerobic exercise, and a low calorie diet with low carbohydrate (≈1300Kcal/d). Those in the control group received a booklet about MetS and were instructed to maintain their usual diet and activities. Anthropometric measures, blood pressure, and serum cardio metabolic parameters were measured at before, during (month 3), completion (month 6), and after completion of the TLM program (month 12). Mixed-model repeated measures ANCOVA with control of age was used. Results: Statistically significant treatment-by-assessment time interaction was observed for waist circumference ( P = .010). Waist circumference decreased in the TLM group ( d = − 9cm, 9.5%) over 12 months, compared with standard recommendation group ( d = − 2cm). Systolic blood pressure ( d = − 5mmHg, P = .017), HDL-cholesterol ( d = + 4.6mg/dl, P = .041), and Triglyceride ( d = + 3 mg/dl, P &lt; .001) showed both treatment and time main effects. BMI showed a significant treatment effect ( P &lt; .001) and LDL-C had a time effect ( P = .011). Fasting blood sugar (FBS) did not show treatment by time interaction or main effects ( P &gt; .05), however, treatment group returned to the normal range of FBS at month 12, while it did not in control group. Conclusion : The results indicate that 6-month systematic TLM program have considerable beneficial effects on cardiometabolic risk factors in women with MetS.
Evaluation Of Two Prognostic Scoring Systems For Chronic Myelomonocytic Leukemia (CMML): CMML-Specific Prognostic Scoring System (CPSS) and MD Anderson Prognostic Score (MDAPS) In A Series Of 122 Cases Of De Novo CMML
Authors: Xavier Calvo, Meritxell Nomdedeu, Dolors Costa, Arturo Pereira, Núria Martínez, Jordi Esteve, Blanca Xicoy, Benet Nomdedeu
Journal: Blood (2013)
Abstract 11830: Usefulness of Minimally Invasive Low Energy Defibrillation Test In Patients with Implantable Cardioverter Defibrillator
Authors: Daisuke Kutsuzawa, Takanori Arimoto, Daisuke Ishigaki, Tadateru Iwayama, Harutoshi Tamura, Satoshi Nishiyama, Hiroki Takahashi, Tetsuro Shishido, Takehiko Miyashita, Tetsu Watanabe, Isao Kubota
Journal: Circulation (2011)

Introduction: It was reported that defibrillation test post implantable cardioverter defibrillator (ICD) implantation was necessity from the aspect of long-term prognosis, but then it was reported ...
Evaluation of Ranolazine in Patients With Type 2 Diabetes Mellitus and Chronic Stable Angina
Authors: Mikhail Kosiborod, Suzanne V. Arnold, John A. Spertus, Darren K. McGuire, Yan Li, Patrick Yue, Ori Ben-Yehuda, Amos Katz, Philip G. Jones, Ann Olmsted, Luiz Belardinelli, Bernard R. Chaitman
Journal: Journal of the American College of Cardiology (2013)
Adenine: an important drug scaffold for the design of antiviral agents
Authors: Changyuan Wang, Zhendong Song, Haiqing Yu, Kexin Liu, Xiaodong Ma
Journal: Acta Pharmaceutica Sinica B (2015)

Adenine derivatives, in particular the scaffold bearing the acyclic nucleoside phosphonates (ANPS), possess significant antiviral and cytostatic activity. Till now, several effective adenine derivatives have been marketed for the treatment of HIV, HBV, CMV and other virus-infected diseases. These compounds are represented by tenofovir (PMPA), a medicine for both HIV and HBV, and adefovir as an anti-HBV agent. More than this, other analogs, such as GS9148, GS9131, and GS7340, are also well-known anti-viral agents that have been progressed to the clinical studies for their excellent activity. In general, the structures of these compounds include an adenine nucleobase linked to a phosphonate side chain. Considerable structural modifications on the scaffold itself and the peripheral sections were made. The structure-activity relationships (SARs) of this skeleton will provide valuable clues to identify more effective adenine derivatives as antiviral drugs. Here, we systematically summarized the SARs of the adenine derivatives, and gave important information for further optimizing this template.
Benefit of Adjuvant Chemotherapy for Resectable Gastric Cancer
Authors: Gastric (Global Advanced), Xavier Paoletti, Koji Oba, Tomasz Burzykowski, Stefan Michiels, Yasuo Ohashi, Jean-Pierre Pignon, Philippe Rougier, Junichi Sakamoto, Daniel Sargent, Mitsuru Sasako, Eric Van Cutsem, Marc Buyse
Journal: JAMA (2010)

<h3>Context</h3>Despite potentially curative resection of stomach cancer, 50% to 90% of patients die of disease relapse. Numerous randomized clinical trials (RCTs) have compared surgery alone with adjuvant chemotherapy, but definitive evidence is lacking.<h3>Objectives</h3>To perform an individual patient-level meta-analysis of all RCTs to quantify the potential benefit of chemotherapy after complete resection over surgery alone in terms of overall survival and disease-free survival, and to further study the role of regimens, including monochemotherapy; combined chemotherapy with fluorouracil derivatives, mitomycin C, and other therapies but no anthracyclines; combined chemotherapy with fluorouracil derivatives, mitomycin C, and anthracyclines; and other treatments.<h3>Data Sources</h3>Data from all RCTs comparing adjuvant chemotherapy with surgery alone in patients with resectable gastric cancer. We searched MEDLINE (up to 2009), the Cochrane Central Register of Controlled Trials, the National Institutes of Health trial registry, and published proceedings from major oncologic and gastrointestinal cancer meetings.<h3>Study Selection</h3>All RCTs closed to patient recruitment before 2004 were eligible. Trials testing radiotherapy; neoadjuvant, perioperative, or intraperitoneal chemotherapy; or immunotherapy were excluded. Thirty-one eligible trials (6390 patients) were identified.<h3>Data Extraction</h3>As of 2010, individual patient data were available from 17 trials (3838 patients representing 60% of the targeted data) with a median follow-up exceeding 7 years.<h3>Results</h3>There were 1000 deaths among 1924 patients assigned to chemotherapy groups and 1067 deaths among 1857 patients assigned to surgery-only groups. Adjuvant chemotherapy was associated with a statistically significant benefit in terms of overall survival (hazard ratio [HR], 0.82; 95% confidence interval [CI], 0.76-0.90; P &lt; .001) and disease-free survival (HR, 0.82; 95% CI, 0.75-0.90; P &lt; .001). There was no significant heterogeneity for overall survival across RCTs (P = .52) or the 4 regimen groups (P = .13). Five-year overall survival increased from 49.6% to 55.3% with chemotherapy.<h3>Conclusion</h3>Among the RCTs included, postoperative adjuvant chemotherapy based on fluorouracil regimens was associated with reduced risk of death in gastric cancer compared with surgery alone.