Cytogenetic Studies in Eosinophilic Leukemia
Authors: KONG-OO GOH
Journal: Annals of Internal Medicine (1965)

Article1 January 1965Cytogenetic Studies in Eosinophilic LeukemiaThe Relationship of Eosinophilic Leukemia and Chronic Myelocytic LeukemiaKONG-OO GOH, M.D., SCOTT N. SWISHER, M.D., CHARLES A. ROSENBERG, M.D.KONG-OO GOH, M.D.Search for more papers by this author, SCOTT N. SWISHER, M.D.Search for more papers by this author, CHARLES A. ROSENBERG, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-62-1-80 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptFrequently moderate degrees of hyper-eosinophilia have been found to be associated with many diseases (1). However, there are occasional cases in which the eosinophilia cannot be ascribed to a primary disease. Some of these cases are thought to be either myelocytic leukemia of eosinophilic variety or eosinophilic leukemia (2, 3).In 1960, Nowell and Hungerford (4) described an abnormal small acrocentric chromosome in patients with chronic myelocytic leukemia. This abnormal chromosome has been called the Philadelphia chromosome or Ph1(5). This abnormal chromosome has been thought to be typical of chronic myelocytic leukemia by many authors (6-9). Experience in this...References1. WINTROBE MM: Clinical Hematology, 5th ed. Lea and Febiger, Philadelphia, 1961, pp. 257 and 938. Google Scholar2. LEPAK JA: Eosinophilic leukemia or myelogenous leukemia with eosinophilic hyperleukocytosis. Minnesota Med. 23: 596, 1940. Google Scholar3. HODGSONKAUMPSTEINERBOVILL JRDHGJ: Myeloid leukemia, probably eosinophilic in character. Amer. J. Clin. Path. 15: 389, 1945. CrossrefMedlineGoogle Scholar4. NOWELLHUNGERFORD PCDA: A minute chromosome in human chronic granulocytic leukemia (abstract). Science 132: 1497, 1960. Google Scholar5. TOUGHCOURT-BROWNBAIKIEBUCKTONHARNDENJACOBSKINGMCBRIDE IMWMAGKEDGPAMJJA: Cytogenetic studies in chronic myeloid leukaemia and acute leukaemia associated with mongolism. Lancet 1: 411, 1961. CrossrefMedlineGoogle Scholar6. NOWELLHUNGERFORD PCDA: Chromosome studies in human leukemia. II. Chronic granulocytic leukemia. J. Nat. Cancer Inst. 27: 1013, 1961. MedlineGoogle Scholar7. SANDBERGISHIHARACROSSWHITEHAUSCHKA AATLHTS: Comparison of chromosome constitution in chronic myelocytic leukemia and other myeloproliferative disorders. Blood 20: 393, 1962. CrossrefMedlineGoogle Scholar8. NOWELLHUNGERFORD PCDA: Chromosome studies in human leukemia. IV. Myeloproliferative syndrome and other atypical myeloid disorders. J. Nat. Cancer Inst. 29: 911, 1962. MedlineGoogle Scholar9. FITZGERALDADAMSGUNZ PHAFW: Chronic granulocytic leukemia and the Philadelphia chromosome. Blood 21: 183, 1963. CrossrefMedlineGoogle Scholar10. GOHSWISHER KOSN: Studies of the Philadelphia chromosome (abstract). Ann. Intern. Med. 60: 729, 1964. LinkGoogle Scholar11. EVANSNESBIT TSRR: Eosinophilic leukemia. Blood 4: 603, 1949. CrossrefMedlineGoogle Scholar12. BENTLEYREANDONKNOEDLERKRIVIT HPAEJPW: Eosinophilic leukemia, report of a case, with review and classification. Amer. J. Med. 30: 310, 1961. CrossrefGoogle Scholar13. HUNGERFORDDONNELLYNOWELLBECK DAAGPCS: The chromosome constitution of human phenotypic intersex. Amer. J. Hum. Genet. 11: 215, 1959. MedlineGoogle Scholar14. TJIOWHANG JHJ: Chromosome preparations of bone marrow cells without prior in vitro culture or in vivo colchicine administration. Stain Techn. 37: 17, 1962. CrossrefMedlineGoogle Scholar15. HUNGERFORD DA: Chromosome studies in human leukemia. I. Acute granulocytic leukemia in children. J. Nat. Cancer Inst. 27: 983, 1961. MedlineGoogle Scholar16. HUNGERFORDNOWELL DAPC: Chromosome studies in human leukemia. III. Acute granulocytic leukemia. J. Nat. Cancer. Inst. 29: 545, 1962. MedlineGoogle Scholar17. GOHSWISHER KOSN: Unpublished observations. Google Scholar18. ISHIHARAMOORESANDBERG TGEAA: Chromosome constitution of cells in effusions of cancer patients. J. Nat. Cancer Inst. 27: 893, 1961. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Rochester and Batavia, New YorkFrom the Departments of Medicine and Obstetrics-Gynecology, University of Rochester School of Medicine and Dentistry, Rochester, New York, and the Department of Medicine, Veterans Administration Hospital, Batavia, N. Y.This study was supported in part by the Monroe County Cancer Association, a general research support grant (Fr-05103-01), U. S. Public Health Service, Bethesda, Md., and the Blood Research Fund of the University of Rochester, Rochester, N. Y.Requests for reprints should be addressed to Kong-oo Goh, M.D., Cytogenetic Program, Medical Division, Oak Ridge Institute of Nuclear Studies, Oak Ridge, Tennessee 37831. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByThe eosinophilias, including the idiopathic hypereosinophilic syndromeClinical and cytogenetic remission induced by interferon-α in a patient with chronic eosinophilic leukemia associated with a unique t(3;9;5) translocationClonal eosinophilic disorders and the hypereosinophilic syndromeA unique chromosomal abnormality in idiopathic hypereosinophilic syndrome presenting with cardiac involvementEvidence for the clonal nature of hypereosinophilic syndromeAbnormalities of chromosome 12p 13 and malignant proliferation of eosinophils: a nonrandom associationIs hypereosinophilic syndrome a malignant disease?Eosinophilic blast crisis in a case of chronic myeloid leukaemiaThe Hypereosinophilic Syndrome: Clinical Features, Laboratory Findings and TreatmentThe Idiopathic Hypereosinophilic Syndrome Clinical, Pathophysiologic, and Therapeutic ConsiderationsANTHONY S. FAUCI, M.D., JOHN B. HARLEY, M.D., Ph.D., WILLIAM C. ROBERTS, M.D., VICTOR J. FERRANS, M.D., Ph.D., HARVEY R. GRALNICK, M.D., BARBARA H. BJORNSON, M.D.Chromosomal Aberrations in Eosinophilic LeukemiaChromosomes and causation of human cancer and leukemia. XXXIV. A case of “hypereosinophilic syndrome” with unusual cytogenetic findings in a chloroma, terminating in blastic transformation and CNS leukemiaChromosomal Anomaly in Eosinophilic LeukemiaDie chronische myeloische LeukämieChromosomal aneuploidy in a patient with hypereosinophilic syndromePh1-Negative Eosinophilic Leukaemia with Trisomy 8 Case Report and Review of Cytogenetic StudiesDifferent Composition of the Eosinophilic Bone Marrow Pool in Reactive Eosinophilia and Eosinophilic LeukaemiaEosinophilic leukemiaIsochromosome 17 in a Case of Eosinophilic LeukaemiaSerum vitamin B12-binding proteins in a case of eosinophilic leukemiaChromosomal Changes in Human Tumors and LeukemiasAnomalies of the Small Acrocentric (chromosomes in Human Tumour Cells*Eosinophilic leukemoid reactionDas Philadelphia ChromosomEXTREME PERSISTENT EOSINOPHILIA WITH HIGH SERUM B12 VALUESEosinophilie Leukemia Report of Five Cases and Review of LiteratureDAN S. BENVENISTI, M.D., F.A.C.P., JOHN E. ULTMANN, M.D., F.A.C.P.Endomyocardial disease and eosinophiliaChromosomenbefunde bei Erkrankungen des blutbildenden SystemsThe Hypereosinophilic SyndromesWILLIAM R. HARDY, M.D., ROBERT E. ANDERSON, M.D.Continuous culture of seven new cell lines (SK-L1 to 7) from patients with acute leukemiaHistory of Cancer Genetics in ManPhiladelphia chromosome in eosinophilic leukemiaHuman cytogenetics 1 January 1965Volume 62, Issue 1Page: 80-86KeywordsChromosomesChronic myelocytic leukemiaCytogeneticsDentistryEosinophiliaHospital medicineMedical servicesObstetrics and gynecologyResearch fundingResearch grants Issue Published: 1 January 1965 PDF DownloadLoading ...