tbuckley/cabot-search huggingface dataset:
Abstract 3841: Exploration of the Mechanisms of Pacing Postconditioning
Authors: Fawzi A Babiker, Ward Y Vanagt, Tammo Delhaas, J. Waltenberger, Jack Cleutjens, Frits Prinzen
Journal: Circulation (2009)

Purpose: We previously showed that intermittent dyssynchrony, induced by ventricular pacing immediately upon reperfusion, induces cardioprotection (pacing-postconditioning, (PPC). We hypothesized t...
Abstract 2672: Depression is Associated with Decreased Coronary Flow Reserve Detected by Means of Positron Emission Tomography: A Twin Study
Authors: Viola Vaccarino, Ali Ashraf, Tracy Faber, John Votaw, Anthony DeBalsi, Jack Goldberg, Arshed A Quyyumi, Nancy Murrah, Linda Jones, Carisa Maisano, Olga Novik, Jinying Zhao, J. D Bremner
Journal: Circulation (2006)
Use of statins
Authors: L E Ramsay, E J Wallis, I U Haq, R Williamson, W W Yeo, P R Jackson
Journal: BMJ (1998)

How to use the Risk Tables1 To estimate a person's absolute annual risk of a cardiovascular event (newly diagnosed angina, MI, CHD death, stroke or TIA) identify the table relating to person's sex, diabetes status, smoking status and age (locate closest) 2 Within the table find the cell nearest to the person's blood pressure and TC:HDL-C ratio 3 Compare cell colour with risk level 4 For patients with a strong family history of CHD, increase their risk level by at least one colour category
Abstract P388: Trends in Socioeconomic Disparities in Ideal Cardiovascular Health: NHANES 1999–2006
Authors: Norrina B Allen, Hongyan Ning, Donald Lloyd-Jones
Journal: Circulation (2012)

Background: Socioeconomic status (SES) has been shown to be associated with many cardiovascular (CV) risk factors. Prior studies have identified differences by SES, but have not summarized trends in these disparities across multiple SES subgroups, which could allow us to assess the extent to which we are achieving disparity-related goals. Methods: We used NHANES Surveys from cycles 1999–2000, 2001–2002, 2003–2004, and 2005–2006 to examine the age-adjusted prevalence of ideal levels of CV health components by SES. Ideal levels of BMI, cholesterol, glucose, blood pressure, diet, physical activity and smoking were defined according to the AHA 2020 strategic goals. SES was defined by poverty: income ratio and categorized as &lt;1.00, 1.00-2.99, and 3.00+. Both absolute (Absolute Concentration Index- ACI) and relative measures (Relative Concentration Index -RCI) of disparities were calculated, all calculations were weighted by population share. The percentage change in disparities relative to 1999–2000 was examined. Results: Age-adjusted rates of ideal CV health components and the percentage change from 1999–2006 varied by SES (see Table). Among women, disparities in the prevalence rates of ideal levels of CV risk factors have increased between SES groups from 1999 through 2006. Among men, disparities in blood pressure (ACI=503%, RCI=477%) and diet (ACI=405%, RCI=143%) have increased most dramatically. More moderate increases were seen in disparities in smoking and cholesterol for men. Disparities in BMI and physical activity remained relatively constant among men throughout the study period. Findings were generally similar for both absolute and relative measures of disparities. Conclusions: Representative national data on these summary measures of disparities suggest that disparities between SES groups have increased among men. Understanding the issues underlying these increasing disparities and addressing them will be critical to improving the cardiovascular health of all Americans by 2020 and beyond.
Abstract 14393: Insulin Resistance and Risk of Incident Heart Failure: Cardiovascular Health Study
Authors: Dipanjan Banerjee, Laina Mercer, Kenneth Mukamal, Robert Kaplan, Lewis Kuller, Jorge Kizer, Luc Djousse, Russell Tracy, Mary L Biggs, Susan Zieman, Donald Lloyd-Jones, David Siscovick, Mercedes Carnethon
Journal: Circulation (2011)

Background Patients with heart failure (HF) have higher fasting insulin levels and a higher prevalence of insulin resistance (IR) when compared to matched controls. IR leads to structural abnormali...
HECTD3: A new e3 ligase upregulated in breast and prostate cancer
Authors: Yi Li, Zhongmei Zhou, Ceshi Chen
Journal: Cancer Research (2008)

AACR Annual Meeting-- Apr 12-16, 2008; San Diego, CA

1790 

Chromosomal region 1p34 undergoes frequent cytogenetic alterations in many types of cancer. The HECTD3 gene, encoding an HECT domain-containing E3 ubiquitin ligase, is located at the 1p34.1 region. HECTD3 mRNA is highly expressed in salivary gland, liver, thyroid, but low in normal breast and prostate tissues. To determine the role of HECTD3 in breast and prostate cancers, we analyzed the gene dosage and expression level of HECTD3 in a variety of breast and prostate tumor cell lines. Using real-time RT-PCR and Northern blot analysis, we found that the HECTD3 mRNA level was significantly up-regulated in 63.3% (19/30) of breast and 62.5% (20/32) of prostate cancer cell lines. HECTD3 levels were not correlated with ER or PR status (p = 0.705 and 1.0, respectively) in breast cancer cell lines. An increase in HECTD3 gene copy number was detected in 48% (14/30, p= 0.0051) and 22% (4/18, p=0.0051) of breast and prostate cancer cell lines, respectively. Additionally, HECTD3 mRNA levels were consistently elevated in all stages of breast cancer: stage I (9/11), IIa (7/8), IIb (4/6), IIIa (7/8), and IV (3/4). In contrast, HECTD3 was over-expressed in approximately 40% of stage II (7/19) and stage III (3/8) prostate tumors. RNAi-mediated HECTD3 knockdown induced cell growth arrest in PC-3 (prostate) and HCC1500 (breast) cancer cell lines. Together, these results suggest that HECTD3 is a novel oncogenic E3 ligase upregulated in human breast and prostate cancer.
Abstract 3275: A novel approach to treat medulloblastoma: The omega-3 fatty acids DHA and EPA reduce medulloblastoma tumor growthin vitroandin vivo
Authors: Linda M. Ljungblad, John-Inge Johnsen, Malin Wickström, Per Kogner, Helena Gleissman
Journal: Cancer Research (2015)

Abstract Background: The omega-3 fatty acids docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA) exert antitumoral properties shown in several cancer types. DHA is found in abundance in the brain and is of importance in normal brain development and maintenance of function including cognitive functions. Medulloblastoma is the most common malignant CNS tumor of childhood. Intensive multimodal treatment is necessary including surgery, radiotherapy and chemotherapy. However, treatment often results in significant neurological sequelae and the risk of resistant relapses is still significant. The neuroprotective and antitumoral properties of omega-3 could therefore be of great benefit. Our aim was to investigate the effect of DHA and EPA on medulloblastoma in vitro and in vivo. Methods: In a panel of medulloblastoma cell lines the cytotoxic activity of DHA and EPA was studied using cell viability assays. The molecular mechanisms were characterized using cell- and molecular biology techniques. Mice with human medulloblastoma xenografts were treated with; DHA alone or with DHA and EPA for 30 days from time of tumor take while tumor growth was monitored. Control mice were fed with normal chow. The incorporation of fatty acids was analyzed in tumors, erythrocytes and brain tissue by LS-MS/MS. Results: DHA and EPA induced medulloblastoma cell toxicity with IC50 values ranging from 1.9 to 68 μM in six medulloblastoma cell lines. DHA reduced the prostaglandin E2 production, indicating a possible mechanism of action. In vivo, omega-3 supplementation resulted in significant reduction of tumor growth when established tumors were treated. DHA levels were increased in both tumor tissue and erythrocyte membrane compared to control. The in vivo treatment was non-toxic. Conclusions: DHA and EPA exert toxic effect on medulloblastoma cells in vitro and reduce tumor growth in vivo. These omega-3 fatty acids could therefore be good candidates for improving current therapy and at the same time protect healthy neurons from therapy-induced toxicity promoting cognitive function in survivors. Thus, omega-3 fatty acid supplementation has the potential of reducing tumor growth as well as reducing sequelae. Citation Format: Linda M. Ljungblad, John-Inge Johnsen, Malin Wickström, Per Kogner, Helena Gleissman. A novel approach to treat medulloblastoma: The omega-3 fatty acids DHA and EPA reduce medulloblastoma tumor growth in vitro and in vivo. [abstract]. In: Proceedings of the 106th Annual Meeting of the American Association for Cancer Research; 2015 Apr 18-22; Philadelphia, PA. Philadelphia (PA): AACR; Cancer Res 2015;75(15 Suppl):Abstract nr 3275. doi:10.1158/1538-7445.AM2015-3275
Five Genetic Variants Associated with Prostate Cancer
Authors: Coral E Gartner, Jan J Barendregt, Wayne D Hall
Journal: New England Journal of Medicine (2008)

The increasing availability of whole-genome sequence data is expected to increase the accuracy of genomic prediction. However, results from simulation studies and analysis of real data do not always show an increase in accuracy from sequence data compared to high-density (HD) single nucleotide polymorphism (SNP) chip genotypes. In addition, the sheer number of variants makes analysis of all variants and accurate estimation of all effects computationally challenging. Our objective was to find a strategy to approximate the analysis of whole-sequence data with a Bayesian variable selection model. Using a simulated dataset, we applied a Bayes R hybrid model to analyse whole-sequence data, test the effect of dropping a proportion of variants during the analysis, and test how the analysis can be split into separate analyses per chromosome to reduce the elapsed computing time. We also investigated the effect of imputation errors on prediction accuracy. Subsequently, we applied the approach to a dataset that contained imputed sequences and records for production and fertility traits for 38,492 Holstein, Jersey, Australian Red and crossbred bulls and cows.
Abstract 1623: Reactive Oxygen Species increases Intracellular Calcium, alters the Electrophysiological Properties and Synaptic Transmission in Intrinsic Cardiac Ganglion Neurons: <i>in vitro</i>
Authors: Jhansi Dyavanapalli, Katrina Rimmer, Alexander A Harper
Journal: Circulation (2008)

Anerobic metabolism generates reactive oxygen species (ROS) as by-products and this is increased during ischemia. ROS have been shown to interact with and impair the functioning of membrane proteins such as ion channels and transporters and cause disturbances in intracellular Ca 2+ homeostasis. We have investigated the effects of ROS upon [Ca 2+ ] i , the intrinsic electrophysiological characteristics and synaptic transmission in neurons of the ICG regulating the sinoatrial node. The hypothesis is that ROS-induced damage increases [Ca 2+ ] i and attenuates synaptic transmission in ICG. used a whole-mount adult rat ICG preparation, in vitro (rats were killed by stunning and cervical dislocation, according to current UK Home Office guidelines). Intracellular recordings were made using sharp glass microelectrodes filled with Oregon Green 488 BAPTA-1, allowing simultaneous recording of electrical properties and measurement of [Ca 2+ ] i . Signals resulting from [Ca 2+ ] i changes were expressed as the ratio of fluorescence changes over baseline fluorescence, (f-fo)/fo . The ROS-donors hydrogen peroxide (H 2 O 2 , 1 mM) and tert-butyl hydroperoxide ( t -BHP, 1mM) had broadly similar actions on postganglionic somata, both producing membrane potential hyperpolarization (from −48.4 mV ± 6.5 S.D control to −69.9 mV ± 7.9 H 2 O 2 , n=7; and from −51.9 mV ± 7.1 control to −59.2 mV ± 7.9 t -BHP, n=17, p&lt;0.001). Considering the somatic action potential (AP), t -BHP decreased the rate of rise (from 159 V/sec ± 79 control to 117 V/sec ± 53, n=6, p&lt;0.05), but did not alter the rate of fall and increased AP duration (measured at 0 mV) from 0.7ms (± 0.2) control to 1.1ms (± 0.3, n=5, p&lt;0.05). In addition, t -BHP reduced the AP afterhyper-polarization (AHP) amplitude (from 15.5 mV ± 5.2 control to 9.9 mV ± 4.5, n=10, p&lt;0.001) but had no impact on AP overshoot or AHP duration. t -BHP and H 2 O 2 markedly increased resting [Ca 2+ ] i to 1.59 (± 0.03, n=8,p&lt;0.001) and 2.36 (± 0.04, n=3, p&lt;0.05) respectively, of control values (~ 60 nM ). H 2 O 2 blocked synaptic transmission in 3 /4 neurons. In contrast, t -BHP had no significant action on synaptic transmission. Together, these data demonstrate that ROS alters the excitability of ICG neurons attenuating parasympathetic control of the heart during ischemia/ reperfusion.
Systemic Effects of Anisoylated Plasminogen Streptokinase Activator Complex and Streptokinase Therapy in Acute Myocardial Infarction
Authors: J. J.M.L. Hoffmann, J. J.R.M. Bonnier, J. B.R.M. de Swart, P. Custers, M. Vijgen
Journal: Drugs (1987)
Agencies Speak Out on Rape in DarfurAgencies Speak Out on Rape in Darfur
Authors: Tracy Hampton
Journal: JAMA (2005)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Prevalence and Causes of Visual Impairment in Rural Myanmar
Authors: Robert J. Casson, H.S. Newland, J. Muecke, S. McGovern, S. Durkin, T. Sullivan, T.Z. Oo, T.H. Aung, W.K. Shein, D. Selva, T. Aung
Journal: Ophthalmology (2007)
CE7 epitope of L1CAM is a potential target for tumor specific T cell therapy in lung cancer
Authors: Karen Reckamp, Michael Statsny, Christine Brown, Michael Jensen
Journal: Cancer Research (2008)

AACR Annual Meeting-- Apr 12-16, 2008; San Diego, CA

4620 

Lung cancer is the leading cause of cancer death in the United States with an overall 5-year survival of 15%. New strategies for the treatment of lung cancer are clearly needed. Genetically engineering effector T-cells with functional capabilities to overcome the obstacles of immunosuppression and specific T cell anergy is a conceptually attractive strategy for treating lung cancer. L1CAM has been shown to be overexpressed in multiple tumors and associated with invasive/metastatic tumor biology. Published reports, as well as our own preliminary data, have demonstrated L1-CAM expression on a panel of SCLC and NSCLC lines. The L1-CAM specific monoclonal antibody CE7 from which the CE7R CAR was derived binds to an epitope on the L1 adhesion molecule with high affinity (Ka=10-11). L1 is an immunoglobulin superfamily high-molecular-mass glycoprotein of approximately 200kDa that mediates homophilic cell-cell adhesion. CE7 appears to bind to a tumor-specific epitope on L1-CAM based on aberrant splice variants expressed by tumor cells. We evaluated the CE7 epitope on small cell (SCLC) and non-small cell lung cancer (NSCLC) cell lines by FACS and western blot. Cyototoxic T lymphocyte (CTL) killing was assessed by 4-hour chromium release assays. We also evaluated the targeting of L1-CAM expressing lung cancer cell lines with cytolytic T cells genetically modified using SIN lentiviral vectors to express a L1-CAM specific chimeric antigen receptor composed of an scFv derived from the CE7 hybridoma that is in turn fused to IgG4:CD4Tm:CD3-ζcyto (CE7R). We found that CE7 monoclonal antibody (mAb) binds to tumor L1-CAM on lung cancer lines, especially small cell lung cancer lines. CE7R expressing CTL can kill L1-CAM-expressing lung cancer cells via CE7R mediated recognition and CTL activation as evidenced by dose-dependent blocking with CE7 monoclonal antibody. Pre-clinical orthotopic and metastatic murine models of lung cancer adoptive therapy have been established using biophotonic reporters and in vivo Xenogen and micro-computed tomography imaging. These data and future murine modeling will further validate L1-CAM as a target on human lung cancer and potential target for novel T cell therapies.    Supported by K12 CA 01727 and the Phase One Foundation.
ENESTnd Update: Nilotinib (NIL) Vs Imatinib (IM) In Patients (pts) With Newly Diagnosed Chronic Myeloid Leukemia In Chronic Phase (CML-CP) and The Impact Of Early Molecular Response (EMR) and Sokal Risk At Diagnosis On Long-Term Outcomes
Authors: Giuseppe Saglio, Andreas Hochhaus, Timothy P. Hughes, Richard E. Clark, Hirohisa Nakamae, Dong-Wook Kim, Saengsuree Jootar, Gabriel Etienne, Ian Flinn, Jeffrey H. Lipton, Ricardo Pasquini, Beatriz Moiraghi, Charisse Kemp, Xiaolin Fan, Hans D. Menssen, Hagop M. Kantarjian, Richard A. Larson
Journal: Blood (2013)
Abstract 9599: Coronary Plaque Burden Assessed With Coronary Computed Tomography Angiography Predicts Future Coronary Events in Patients With Familial Hypercholesterolemia
Authors: Hayato Tada, Masa-aki Kawashiri, Akihiko Hodatsu, Chiaki Nakanishi, Tetsuo Konno, Kenji Sakata, Tsuyoshi Yoshimuta, Kenshi Hayashi, Atsushi Nohara, Akihiro Inazu, Hiroshi Mabuchi, Masakazu Yamagishi
Journal: Circulation (2014)

Objectives:  The aim of this study was to determine whether accumulation of coronary plaque burden assessed with coronary computed tomography angiography (CCTA) can predict future events in patients with familial hypercholesterolemia (FH).   Background:  Although CCTA has demonstrated high diagnostic performance for detection and exclusion of obstructive coronary artery disease (CAD), the prognostic findings of CAD by CCTA have not, to date, been examined for the patients with FH which usually exhibit premature coronary atherosclerosis.   Methods:  We evaluated a consecutive cohort of 102 heterozygous FH patients (male = 52, mean LDL-C = 277±58mg/dl) undergoing 64-detector row CCTA between 2008 and 2012 without known CAD, retrospectively. In those patients, we assessed coronary plaque burden assigning score (0 to 5) to each of 15 coronary artery segments according to the Society Cardiovascular Computed Tomography (SCCT) guideline. Those scores were summed and natural log-transformed. Time to major adverse cardiac events (MACE), including coronary revascularizations was estimated using multivariable Cox proportional hazards models.   Results:  During the follow-up period (median 941 days), 21 MACE had occurred. Receiver-operating characteristic curve analyses identified the plaque burden score of 3.35 as the optimal cutoff for predicting prognosis, the sensitivity and specificity of which were 85.7% and 82.5%, respectively with an AUC of 0.90. Multivariate Cox regression analysis identified the presence of plaque score ≥ 3.35 as the significant independent predictor of MACE (HR = 3.65; 95%CI 1.32 to 25.84, p   Conclusions:  Coronary plaque burden identified in a noninvasive, quantitative manner was significantly associated with future coronary events in patients with FH. These findings support the use of CCTA for risk assessment in FH.
Abstract 12491: Impact of Positive Thrombus Retrieval During Primary Percutaneous Coronary Intervention with Thrombectomy on Infarct Size and Microvascular Obstruction
Authors: Romain Chopard, Philoktimon Plastaras, Jerome Jehl, Vincent Descotes-Genon, Marie-France Seronde, Sebastien Janin, Alexandre Guignier, Bruno Kastler, Francois Schiele, Nicolas F Meneveau
Journal: Circulation (2011)

Background: Thromboaspiration (TA) during primary percutaneous intervention (PPCI) is effective in opening the infarct-related artery in patients with ST-segment elevation myocardial infarction (ST...
People do not apply enough sunscreen for protection
Authors: B L Diffey
Journal: BMJ (1996)

EDITOR,—Despite the conventional wisdom that sunscreens should be recommended to prevent cutaneous malignant melanoma, evidence supporting this is lacking. J M McGregor and A R Young1 comment on the apparent increased risk of melanoma in people who use sunscreens.2 They suggest that people who use sunscreens containing ingredients that mainly absorb ultraviolet B spend longer in the sun because of the reduced risk of sunburn and so increase their dose of ultraviolet A radiation …
Abstract 3484: Dietary Patterns And The Risk Of Mortality From All-causes, Cardiovascular Disease, And Cancer In Women
Authors: Christin Heidemann, Matthias B Schulze, Oscar H Franco, Rob M van Dam, Christos S Mantzoros, Frank B Hu
Journal: Circulation (2007)

Background: Few studies have investigated the impact of dietary patterns that reflect existing eating habits on the risk of all-cause or cause-specific mortality. Objective: To prospectively examine the relation between major dietary patterns and the risk of all-cause and cause-specific mortality among women of the Nurses’ Health Study. Methods: The participants included 72,113 women aged 35 to 55 years without a history of cancer, myocardial infarction, angina, coronary artery surgery, stroke, or diabetes at baseline. Dietary patterns were derived by factor analysis using information from five repeated, validated food frequency questionnaires that were administrated at baseline and every 2 to 4 years during the follow-up period (1984–2002). Cox proportional hazards regression was used to adjust for covariates including age, cigarette smoking, physical activity, body mass index, and further suspected risk factors. Results: Two major dietary patterns were identified. High prudent pattern scores represented high intakes of vegetables, fruit, legumes, fish, poultry, and whole grains, whereas high western pattern scores represented high intakes of red meat, processed meat, refined grains, french fries, condiments, and sweets and desserts. During 18 years of follow-up (633,516 person-years), we ascertained 6,011 deaths, including 3,139 cancer deaths and 1,154 cardiovascular deaths. After adjustment for potential confounders, the prudent diet was inversely associated with all-cause mortality (relative risk [RR] = 0.83 for highest versus lowest quintile, 95% confidence interval [CI] = 0.76 – 0.90, p for trend &lt; 0.0001) and cardiovascular mortality (RR = 0.72, 95% CI = 0.60 – 0.87, p for trend = 0.0007), but not with cancer mortality (RR = 0.99, 95% CI = 0.88 –1.11, p for trend = 0.87). The western pattern was directly associated with all-cause mortality (RR = 1.21, 95% CI = 1.11–1.32, p for trend &lt; 0.0001), cardiovascular mortality (RR = 1.22, 95% CI = 1.00 –1.48, p for trend = 0.01), and cancer mortality (RR = 1.15, 95% CI = 1.02–1.29, p for trend = 0.004). Conclusions: These data provide evidence that a high prudent pattern score and a low western pattern score may reduce the risk of total and cause-specific mortality.