tbuckley/cabot-search huggingface dataset:
Abstract 18613: Improved Adolescent Pre-Athletic Screening Sensitivity and Specificity with Seattle Criteria-interpreted ECGs
Authors: Jamie N Colombo, Ricardo Samson, Santiago Valdes, David Sisk, Scott Klewer
Journal: Circulation (2014)

Introduction:  Sudden cardiac arrest (SCA) is a rare but devastating cause of death in children and young adults. While electrocardiogram (ECG) can detect many causes of SCA, ECG are not routinely included in pre-athletic screening (PAS) protocols in the United States due, in part, to a high rate of false positive (FP) interpretations in adolescents. Recently, an expert consensus panel developed refined ECG criteria (Seattle Criteria) to improve the specificity for ECG identification of cardiac conditions associated with SCA.   Methods:  We compared standard ECG criteria with Seattle Criteria in the interpretation of ECGs obtained as part of a youth community SCA screening program. Students completed an AHA-endorsed PAS that included a cardiac specific history and physical exam. A 12 lead ECG was obtained and interpreted by a board certified pediatric cardiologist (PDC). Students found to have a positive PAS screen or abnormal standard ECG completed additional work up with a PDC. All ECGs referred for additional evaluation were interpreted by a PDC using Seattle Criteria in a blinded manner.   Results:  A total of 1,034 students 11-13 years of age were evaluated. No referrals for additional testing were made based on PAS history alone. There were 72 (7%) ECG abnormalities identified by standard PDC interpretation, while Seattle Criteria identified 21 (2%) ECGs that met criteria for further testing. Formal cardiology evaluation confirmed 4 students at risk for SCA (0.38%); LQTS (n=2), WPW (n=1) and PHTN (n=1); incidental findings isolated RBBB (n=1), MVP (n=1) and PFO (n=1). All students at risk for SCA were identified by both standard pediatric ECG and Seattle Criteria interpretations. Specificity for standard ECG was 93% and for Seattle criteria was 98%.   Conclusions:  This study demonstrates that inclusion of ECGs in PAS improves the sensitivity for identifying middle school students at risk for SCA compared to history and exam alone. While standard pediatric ECG interpretation yields a 6.5% incidence of FP, application of Seattle Criteria reduces the incidence of FP ECGs in this age group to 1.6% with no adverse effect on sensitivity. This data supports utilizing Seattle Criteria interpretation for community SCA screening programs that include ECG.
475. Anionic Polyethyleneglycol Lipids Added to Cationic Lipoplexes Increase Their Plasmatic Circulation Time
Authors: Céline Nicolazzi, Nathalie Mignet, Nathalia Dela Figuera, Mamonjy Cadet, Raoul Torero Ibad, Johanne Seguin, Daniel Scherman, Michel Bessodes
Journal: Molecular Therapy (2004)

Cationic liposomes have been widely sensed as good DNA compacting delivery agents. Although their use generally met with encouraging results in vitro, the results in vivo were rather disappointing, as they strongly interact with the blood components before they can reach the therapeutic target. Polyethyleneglycol (PEG) shielding has been proposed as a way to alleviate this effect, but was still found unsatisfactory in most instances for systemic administration. We demonstrate here that the insertion of anionic functions between the lipid part and the PEG, at a correct distance to favor electrostatic interactions with the outer cationic layer of the lipoplexes, provides not only a decrease in the mean peripheral charge of the lipoplex ( z potential), but also a greater colloidal stability of the particles in the presence of serum. Transfection in the lung is also decreased with negatively charged PEG shielding, although no significant changes are observed in the tumor. This encouraging new approach should consequently be combined with active extra-cellular receptor targeting to achieve the desired delivery of the therapeutic DNA to tumor tissues.
Chlamydia Infection in Ducks: Preliminary Communication
Authors: C D Bracewell, B J Bevan
Journal: Journal of the Royal Society of Medicine (1982)

Chlamydia psittaci was isolated from cloacal swab pools from ducks in processing plants, and from cloacal and conjunctival swab pools from ducks on farms, in a small proportion of the samples examined. These isolates were difficult to passage. This difficulty was partly overcome by the use of emetine as the cell growth inhibitor. The direct complement fixation (CF) test was modified for testing duck sera by using complement at the los dose of 1.5 units. By this method, positive titres were demonstrated in experimentally prepared duck antisera, and in some of the samples collected from breeding and fattening ducks.
Abstract 2265: Injection of a Biomaterial Polymer Results in Reverse Remodeling of Displaced Papillary Muscles and Reduction in Acute Ischemic Mitral Regurgitation
Authors: Judy Hung, Jorge Solis, J. L Guerrero, Gavin Braithwaite, Orhun K Muratoglu, Miguel Chaput, Suzanne Sullivan, Leticia Fernandez-Friera, Mark D Handschumacher, Van J Wedeen, Gus J Vlahakes, Robert A Levine
Journal: Circulation (2007)

Ischemic mitral regurgitation (IMR) relates to papillary muscle (PM) displacement caused by left ventricular (LV) distortion. We tested the hypothesis that displaced PMs can be repositioned by injection of polyvinyl-alcohol (PVA) polymer, a biologically inert material specially formulated to produce an encapsulated, stable, resilient gel once injected into the myocardium. The aim is to alter the compliance of infarcted myocardium and realign the displaced PMs. Methods : 9 sheep underwent circumflex branch ligation to produce acute IMR. PVA polymer was then injected by echo guidance into the myocardium underlying the infarcted PM. Hemodynamic data, EF, Elastance (Emax), preload-recruitable stroke work (PRSW), relaxation constant tau, and echo data were measured post IMR and post PVA injection. Results : One animal died after coronary ligation and 2 had no IMR; MR was moderate in the remaining 6. PVA injection decreased MR vena contracta from 5±0.4mm to 2±0.7mm (p&lt;0.0001), with decreased tethering distance from infarcted PM to mitral annulus (27±4 to 24±4mm, p&lt;0.001). PVA injection did not significantly decrease EF (43±6% vs 37±4%, post IMR vs post PVA, p=ns), Emax (1.5±0.53 vs 1.6±0.42), PRSW (33±12 vs 31±5) or tau (63±49 ms vs 70±25 ms). Conclusions : PVA polymer injection can acutely reverse LV remodeling to reposition displaced PMs and decrease IMR without adverse effects on LV systolic or diastolic function. This new approach (to alter pathologic anatomy) offers an alternative for relieving IMR by correcting PM position, thus relieving tethering that causes IMR.
Programs Target Youth Violence Prevention
Authors: Lynne Lamberg
Journal: JAMA (2003)

data and ballistics data to their injury databases. The NVISS site for metropolitan Atlanta has taken firearm injury surveillance a step further by enlisting the help of surgeons at Grady Memorial Hospital, which treats 85% of the survivable gunshot wounds in a metropolitan area of 4 million people, according to Arthur L. Kellermann, MD, MPH, who is a professor and chair of emergency medicine at Emory University, an attending physician at Grady Hospital, and director of the Atlanta NVISS site. “Historically, the surgeons who explored those gunshot wounds might recover bullets or bullet fragments, and then wonder what to do with the bullets,” explains Kellermann. The solution, worked out with the field office of the ATF in Atlanta, was simple: “a glorified drop box.” Bullets recovered during surgery are now labeled and signed by the surgeon, and then dropped into a locked box near the operating room. The surgeons don’t operate just to get a bullet out, Kellermann assures. “But if a bullet . . . has to come out, then we label it and put it in the box.” According to Kellermann, this method ensures that the chain of evidence is preserved for purposes of criminal prosecution, so that Grady Memorial Hospital physicians have never been asked to testify in court that they recovered a particular bullet and transferred it to law enforcement. A law enforcement officer empties the box about once a week, so that officers do not have to wait in the hospital for evidence to be procured during surgery. Ideally, all the recovered bullets will be entered into NIBIN to enhance its capacity to identify patterns of illegal firearm sale and use, says Kellermann. He and others hope that connecting the dots to catch the shooters—and those who illegally supply them—could go a long way to helping prevent homicides.
Children's Drug Testing Needed
Authors: Rebecca Voelker
Journal: JAMA (2000)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Researchers Probe Health Consequences Following the World Trade Center Attack
Authors: Joan Stephenson
Journal: JAMA (2002)

AS A SOMBER NATION OBSERVES THE first anniversary of the September 11 terrorist attacks in New York and Washington, studies are under way to assess the health consequences to people exposed to airborne contaminants created from the destruction of the World Trade Center. The most pervasive effect of the disaster is probably the psychological trauma that has affected people fleeing the destroyed buildings and those who participated in rescue and recovery efforts, as well as an extended network of family, friends, and coworkers (see p 1235 and JAMA. 2001;286:18231825). But there also are continuing concerns about other possible health consequences resulting from exposure to harmful contaminants generated by the collapse of the twin towers (see p 1227).
Echocardiographic predictors of clinical outcome in patients with left ventricular dysfunction enrolled in the SOLVD registry and trials: significance of left ventricular hypertrophy∗∗∗∗A list of participating hospitals, central agencies and personnel appears in reference 26.
Authors: Miguel A. Quiñones, Barry H. Greenberg, Helen A. Kopelen, Chris Koilpillai, Marian C. Limacher, Daniel M. Shindler, Brent J. Shelton, Debra H. Weiner
Journal: Journal of the American College of Cardiology (2000)
Innovation and Service Traditional at University of Michigan Medical School
Authors: S Lurie
Journal: JAMA (2000)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
A Study of the Effect of Lead Arsenate Exposure on Orchardists and Consumers of Sprayed Fruit
Authors: P. A. Neal, W. C. Dreessen, T. I. Edwards, W. H. Reinhardt, S. H. Webster, H. T. Castberg, L. T. Fairhall
Journal: JAMA (1942)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The biocompatibility of titanium cardiovascular devices seeded with autologous blood-derived endothelial progenitor cells
Authors: Hardean E. Achneck, Ryan M. Jamiolkowski, Alexandra E. Jantzen, Justin M. Haseltine, Whitney O. Lane, Jessica K. Huang, Lauren J. Galinat, Michael J. Serpe, Fu-Hsiung Lin, Madison Li, Amar Parikh, Liqiao Ma, Tao Chen, Bantayehu Sileshi, Carmelo A. Milano, Charles S. Wallace, Thomas V. Stabler, Jason D. Allen, George A. Truskey, Jeffrey H. Lawson
Journal: Biomaterials (2010)
Stopping AIDS: AIDS/HIV Public Education and the Mass Media in Europe, by Kaye Wellings, Becky Field Television, AIDS and Risk. A Cultural Studies Approach to Health Communication, by John Tulloch, Deborah Lupton
Authors: S. Chapman
Journal: BMJ (1997)

Kaye Wellings, Becky Field, Addison-Wesley Longman, £19.99, pp 280 ISBN 0 582 29227 1

John Tulloch, Deborah Lupton,

Allen&Unwin, £14.99, pp 236

ISBN 1 86448 224 9

A history of public health will record that the mid-1980s and 1990s were years when health educators took to the mass media with a whole set of new challenges. A major challenge presented by HIV and AIDS was, instead of mostly saying “Don't” and “Stop,” to send the message “Yes, but carefully now.”

Governments, AIDS organisations, and the gay community have sought to raise awareness and concern, counteract stigmatisation, and, perhaps most controversially, “democratise” risk, and have accepted the Sisyphean challenge to eroticise the condom (as someone put …
Nonsuppressible insulin-like activity in human serum
Authors: A. Jakob, Ch. Hauri, E. R. Froesch
Journal: Journal of Clinical Investigation (1968)

Total nonsuppressible insulin-like activity (ILA) of human plasma (measured by the adipose tissue assay) results from the additive effects of at least two distinct components. They differ in molecular size, solubility in acid-ethanol, and in thermostability. More than 90% of nonsuppressible ILA of human plasma is insoluble in acid-ethanol. Its molecular size of 100,000-150,000 remains unchanged by treatment with acid-ethanol, 5 M acetic acid-0.15 M NaCl, urea, and EDTA. It is inactivated by heat. Approximately 5% of total nonsuppressible serum ILA is soluble in acid-ethanol. The molecular weight is 6000-10,000 after partial purification on Sepadex G-75 (acetic acid-NaCl). This molecule is thermostabile for 3 hr at 80 degrees C. When the acid-ethanol soluble molecule with nonsuppressible ILA is chromatographed on Sephadex G-100 at neutral pH, it is eluted in a broad peak corresponding to a molecular weight of approximately 50,000-70,000. When rechromatographed on Sephadex G-75 (acetic acid-NaCl) its mol wt is irreversibly converted from 70,000 to 6000. Most of the insulin-like activity retained on Dowex-50 ("bound insulin") is eluted off Sephadex G-75 (acetic acid-NaCl) at the same column volume as the small molecular weight nonsuppressible ILA. The latter molecule is retained on Dowex-50, whereas big molecular weight nonsuppressible ILA is not.
Prognostic value of RAS, BRAF, and PIK3CA mutations in early-stage colorectal cancer.
Authors: Jennifer Elizabeth Byer, Nishi Kothari, TzuHua Juan, Jamie K. Teer, Michael J. Schell, David Shibata, Richard D. Kim
Journal: Journal of Clinical Oncology (2015)

594 Background: Activating mutations in the KRAS, BRAF and PIK3CA oncogenes deregulate growth-factor pathways and promote metastasis in colorectal cancer (CRC). The prognostic value of these mutations has been reported with conflicting results in early CRC. We evaluated RAS, BRAF, and PIK3CA mutations as prognostic biomarkers in early stage (stage I-III) colorectal cancer (CRC) patients. Methods: Tumor samples collected from 302 early stage CRC patients diagnosed between 1998 and 2010 were analyzed as part of a multi-institutional observational study. Targeted exome sequencing was performed using the Illumina NGS platform with 50-100X coverage of mutations. The BWA/GATK pipeline was used to identify variants and indels. Matched normal samples were not available for comparison to identify somatic mutations, therefore 1000 Genomes was used to filter normal variants. Variants identified in 1000 Genomes with an MAF &lt;0.01 were filtered. Overall survival data was collected via retrospective chart review. Extended RAS, BRAF V600E, and PIK3CA (exon 9 and 20) mutations were evaluated. The log-rank test was used to compare survival distributions. Results: 302 patients were eligible for analysis (53 stage I, 125 stage II, 124 stage III). 109 patients had RAS mutations (KRAS or NRAS), 41 patients had BRAF mutations, and 29 patients had PIK3CA mutations. Of the 247 patients with microsatellite stability (MSS) 98 were RAS mutant, 10 were BRAF mutant, and 19 were PIK3CA mutant. Of the 55 patients with microsatellite instability high (MSI-H) 11 were RAS mutant, 31 were BRAF mutant, and 10 were PIK3CA mutant. BRAF mutation was prognostic for decreased OS (p= 0.0245), particularly in patients with MSS tumors (p=0.0141). RAS and PIK3CA mutations did not have prognostic value for OS (p =0.72 and 0.23 respectively). Conclusions: In early stage colorectal cancer, we confirmed BRAF mutation is prognostic for OS particularly in MSS patients. RAS and PIK3CA mutations did not confer prognostic value.
Tumoricidal activity of tumor necrosis factor–related apoptosis–inducing ligand in vivo
Authors: Henning Walczak, Robert E. Miller, Kiley Ariail, Brian Gliniak, Thomas S. Griffith, Marek Kubin, Wilson Chin, Jon Jones, Anne Woodward, Tiep Le, Craig Smith, Pam Smolak, Raymond G. Goodwin, Charles T. Rauch, JoAnn C.L. Schuh, David H. Lynch
Journal: Nature Medicine (1999)
Japanese society for dialysis therapy renal data registry—a window through which we can view the details of Japanese dialysis population
Authors: Norio Hanafusa, Shigeru Nakai, Kunitoshi Iseki, Yoshiharu Tsubakihara
Journal: Kidney International Supplements (2015)

The Japanese Society for Dialysis Therapy (JSDT) collects the clinical data from all the facilities to create a nation-wide registry system named JSDT Renal Data Registry (JRDR). This survey was begun in 1966 as a form of facility survey. Patient survey started in 1983. More than 95% of facilities respond to the survey on the basis of voluntary work of facility staffs. Therefore, JRDR has the longest history and the most comprehensive coverage. As for the prevalent patients, 304,856 patients are treated by dialysis therapy in Japan as of the year 2011. The demographics of the Japanese dialysis population have been markedly changing in terms of age, primary diagnoses and dialysis vintage. The mean age of prevalent population reaches 66.55 years at the end of 2011. The increase in the numbers of dialysis population is due to the growth of those older than 65 years old. Patients with the vintage longer than 20 years account for 8% of the entire population. Around 38 thousands patients started their dialysis treatments, whereas 31 thousands deceased. The disease burden of cardiovascular diseases as well as infection is substantial due to the demographic changes. Many evidences have been reported from the data obtained from JRDR to date. These findings covers a wide range of dialysis practice and are utilized for the development of JSDT guidelines. Therefore, JRDR has provided indispensable and fundamental data of Japanese dialysis population.
Trial Registration: Ignored to Irresistible—Reply
Authors: Drummond Rennie
Journal: JAMA (2005)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Disorders of the Spleen: Pathophysiology and Management
Authors: Carl Pochedly, Richard H. Sills, Allen D. Schwartz
Journal: Annals of Internal Medicine (1989)

Contributors review the state of current knowledge and document progress in the anatomy and physiology of the spleen. Topics include: general features, pathophysiology, splenomegaly, imaging and surgery, and new trends. The role of the spleen in various diseases is clarified, among them: hypo- and h