MULTIPLE MYELOMA: A STUDY OF 24 PATIENTS TREATED WITH RADIOACTIVE ISOTOPES (P^32 AND SR^88)
Authors: J H LAWRENCE, L R WASSERMAN
Journal: Annals of Internal Medicine (1950)

Article1 July 1950MULTIPLE MYELOMA: A STUDY OF 24 PATIENTS TREATED WITH RADIOACTIVE ISOTOPES (P32 AND SR88)JOHN H. LAWRENCE, M.D., LOUIS R. WASSERMAN, M.D., F.A.C.P.JOHN H. LAWRENCE, M.D.Search for more papers by this author, LOUIS R. WASSERMAN, M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-33-1-41 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe treatment of multiple myeloma has always been discouraging. As in other inoperable malignant conditions, x-ray therapy has been used wherever indicated, and the use of stilbamidine by Snapper has been successful in relieving pain due to myeloma, but no prolongation of life has been apparent.1Urethane has recently been used in the treatment of multiple myeloma by Loge and Rundles.2Subsidence of pain and a decrease of abnormal cells occurred in some cases. In a series of 83 patients studied by Bayrd and Heck, the average length of life in multiple myeloma was 19 months, and the duration seemed...Bibliography1. Snapper I: Stilbamidine and pentamidine in multiple myeloma, J. A. M. A. 133: 157-161, 1947. CrossrefMedlineGoogle Scholar2. LogeRundles JPRW: Urethane (ethyl carbamate) therapy in multiple myeloma, Blood, J. Hematol. 4: 201-216, 1949. Google Scholar3. BayrdHeck EDFJ: Multiple myeloma. A review of 83 proved cases, J. A. M. A. 133: 147-157, 1947. CrossrefMedlineGoogle Scholar4. Gootnick LT: Solitary myeloma: Review of 61 cases, Radiology 45: 385-391, 1945. CrossrefGoogle Scholar5. Fitz-HughHodes TPJ: Clinical experience with radio-phosphorus in the treatment of certain blood dyscrasias, Am. J. M. Sc. 204: 662-665, 1942. CrossrefGoogle Scholar6. Warren S: The therapeutic use of radioactive phosphorus, Am. J. M. Sc. 209: 710-711, 1945. CrossrefGoogle Scholar7. BayrdHall EDBE: Unusual remission after radiophosphorus therapy in a case of "acute plasma cell leukemia," Blood, J. Hematol. 3: 19, 1948. Google Scholar8. ReinhardMooreBierbaumMoore EHCVOSS: Radioactive phosphorus as a therapeutic agent, J. Lab. and Clin. Med. 31: 107-218, 1946. MedlineGoogle Scholar9. GeschickterCopeland CFMM: Multiple myeloma, Arch. Surg. 16: 807-863, 1928. CrossrefGoogle Scholar10. Wintrobe MM: Clinical hematology, 1946, Lea and Febiger, Philadelphia, p. 774. Google Scholar11. LawrenceTuttleScottConnor JHLWKGCL: Studies on neoplasms with the aid of radioactive phosphorus. Total phosphorus metabolism of normal and leukemic mice, J. Clin. Invest. 19: 267-271, 1940. CrossrefMedlineGoogle Scholar12. Pecher C: Biological investigations with radioactive calcium and strontium, Proc. Soc. Exper. Biol. and Med. 46: 86-91, 1941. CrossrefGoogle Scholar13. GraffScottLawrence WSKGJH: The histologic effects of radiophosphorus on normal and lymphomatous mice, Am. J. Roentgenol. and Rad. Ther. 55: 44-54, 1946. Google Scholar14. ErfTuttleLawrence LALWJH: Clinical studies with the aid of radiophosphorus. Retention in blood, the excretion, and the therapeutic effect of radiophosphorus on patients with leukemia, Ann. Int. Med. 15: 487-543, 1941. LinkGoogle Scholar15. Low-BeerLawrenceStone BVJHRS: The therapeutic use of artificially produced radioactive substances, Radiology 39: 573-591, 1942. CrossrefGoogle Scholar16. LawrenceRosenthal JHRL: Multiple myeloma associated with polycythemia. Report of four cases, Am. J. M. Sc. 218: 149-154, 1949. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Berkeley, California*Received for publication November 7, 1949.From the Division of Medical Physics and the Donner Laboratory of Medical Physics, University of California, Berkeley.The radioactive materials were made in the Berkeley cyclotron during the period 1937 to 1945. Thereafter they were furnished by the Atomic Energy Commission from Oak Ridge. This work has been supported by the Markle Foundation and by the Henry Stevens Kiersted Memorial Fund for Medical Research. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByRadiophosphorus Treatment of Myeloproliferative NeoplasmsBone-Seeking Radiopharmaceuticals to Palliate Painful Bone MetastasesStrategies for Management of Prostate Cancer-Related Bone PainPain from Metastatic Bone TumorsMetalloradiopharmaceuticalsUse of radiactive phosphorus in haematologyUnsealed source therapy of painful bone metastases: An updateA potential bone tumor therapeutic agent153Sm-EDTMP: Its synthesis and preliminary structure analysisRadionuclide therapy of intractable bone pain: Emphasis on strontium-89The Palliation of Osseous Metastasis with 32p or 89 Sr Compared with External Beam and Hemibody Irradiation: A Historical PerspectiveTreatment of metastatic bone pain with strontium-89Radionuclide therapy of hematologic disordersResults of 89 Strontium Therapy in Patients with Carcinoma of the Prostate and Incurable Pain from Bone Metastases: A Preliminary ReportThe Radiologist and the Relief of PainZur Lebenserwartung unbehandelter und behandelter PlasmozytomkrankerThe Treatment of Plasma Cell MyelomaMultiple Myeloma Studies of Mouse Plasma Cell Tumor and Human Myeloma Responsiveness to Cyclophosphamide (Cytoxan)DONALD R. KORST, M.D., F.A.C.P., EUGENE P. FRENKEL, M.D., JOHN C. NIXON, M.D.Die Krankheitsdauer und �berlebenszeit beim multiplen MyelomPlasma-Cell MyelomaMULTIPLE MYELOMA: DIAGNOSIS AND MANAGEMENT IN A SERIES OF 57 CASES*JOHN J. KENNY, M.D., WILLIAM C. MOLONEY, M.D., F.A.C.P.The Use of Radioactive Isotopes in MedicineBlutkrankheitenDiagnostic and Therapeutic Aspects of Multiple Myeloma 1 July 1950Volume 33, Issue 1Page: 41-55KeywordsCellsMultiple myelomaMyelomaResearch designResearch fundingResearch laboratories Issue Published: 1 July 1950 PDF DownloadLoading ...