tbuckley/cabot-search huggingface dataset:
TOXIC REACTION TO 2-METHYL-2-N-PROPYL-1,3, PROPANEDIOL DICARBAMATE (MILTOWN AND EQUANIL)
Authors: J E HOLOUBEK, O C THOMAS, J SEGURA
Journal: Annals of Internal Medicine (1957)

Case Reports1 May 1957TOXIC REACTION TO 2-METHYL-2-N-PROPYL-1,3, PROPANEDIOL DICARBAMATE (MILTOWN AND EQUANIL)JOE E. HOLOUBEK, F.A.C.P., M.D., O. C. THOMAS, M.D., JACOB SEGURA, M.D.JOE E. HOLOUBEK, F.A.C.P., M.D.Search for more papers by this author, O. C. THOMAS, M.D.Search for more papers by this author, JACOB SEGURA, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-46-5-1002 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptA new type of tranquilizing drug, Miltown (2-methyl-2-n-propyl-1,3, propanediol dicarbamate),1has been recently introduced for the treatment of anxiety, nervousness and tension states. The incidence of toxic reactions has been minimal. Selling reported adverse reactions in only three out of 187 patients treated with a total of 54,100 tablets. One patient had two fainting spells and a temperature of 102° F. two and one-half hours after taking two tablets. One hundred fifty milligrams of Pyribenzamine orally were given every four hours and in two days the temperature cleared and the edema subsided. Another patient developed urticaria four days after treatment...Bibliography1. Selling LS: Clinical study of a new tranquilizing drug, J. A. M. A. 157: 1594-1596 (Apr. 30) 1955. CrossrefMedlineGoogle Scholar2. Borrus JC: Study of effect of "Miltown" on psychiatric states, J. A. M. A. 157: 1596-1598 (Apr. 30) 1955. CrossrefMedlineGoogle Scholar3. Lemere F: New tranquilizing drug, Northwest Med. 54: 1098-1100 (Oct.) 1955. MedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: *Received for publication January 3, 1956.Requests for reprints should be addressed to Joe E. Holoubek, M.D., 1513 Line Avenue, Shreveport 39, Louisiana. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byArzneiexanthemeHypersensitivity following ingestion of hydroxyzine (Atarax) in a meprobamate-sensitive patientMeprobamate Addiction 1 May 1957Volume 46, Issue 5Page: 1002-1004KeywordsAnxietyEczemaHeadachesIngestionLymphocytesPruritusRashesSyncopeTemperatureUrticaria ePublished: 1 December 2008 Issue Published: 1 May 1957 PDF downloadLoading ...
Update on cholera - Haiti, Dominican Republic, and Florida, 2010.
Authors: P. H. Jenkins, H. J. Montejano, M. J. Abbasi, M. S. Crowley, M. G. O'Brien, V. Conte, M. Etienne, E. Rico, D. G. Rea, R. M. Baker, E. A. Burden, L. D. Gillis, J. J. Hamilton, R. S. Hopkins, A. C. Kite-Powell, E. Merlo
Journal: MMWR Morbidity and Mortality Weekly Report (2010)
Drug points: Anaphylaxis induced by gabexate mesylate
Authors: Y. Matsukawa
Journal: BMJ (1998)

This study has quantified the contribution of experts to a systematic review and has found them to be an essential source for identifying literature.We suggest that appropriate experts should be consulted when performing a systematic review in a developing field that does not have a clearly defined specialist literature.Contributors: RJMcM participated in the analysis, wrote the first draft, and coordinated the redrafting and the editing of the paper.SW participated in the study design and coordinated the analysis.BCD participated in the study design, reviewed the initial search results and supervised the project.DAF participated in the study design and reviewed the initial search results.CJH particpated in the study design and the analysis.RST participated in the design of the search strategy and in identifying and obtaining relevant citations from the searches.SJ participated in identifying and obtaining citations, designed the database used,
Abrams' Angiography: Volume III: Interventional Radiology, by Ed Stanley Baum, Michael Pentecost
Authors: D J Allison
Journal: BMJ (1997)

Ed Stanley Baum, Michael Pentecost: Little Brown, £153.50, pp 1095 ISBN 0 316 08432 8

Revising a work such as Abrams' Angiography , the “bible” of the discipline, is a prodigious task, and the current editors have wisely recognised that updating the subject of interventional radiology is best tackled in its own volume. In previous editions interventional procedures had been scattered throughout the diagnostic text, and their separation into a stand alone volume in this fourth edition symbolises, in the words of the editors, another stage in the growth and evolution of interventional radiological practice.

It might justly be asked whether a textbook is the appropriate vehicle for presenting interventional radiology, given its rate of development and …
A Phase II Randomized Clinical Trial of Intravitreal Bevacizumab for Diabetic Macular Edema
Authors: Ingrid U Scott, Allison R Edwards, Roy W Beck, Neil M Bressler, Clement K Chan, Michael J Elman, Scott M Friedman, Craig Michael Greven, Raj K Maturi, Dante J Pieramici, Michel Shami, Lawrence J Singerman, Cynthia R Stockdale
Journal: Ophthalmology (2007)
Abstract 17086: Increase in Physical Fitness after an Intensive 12-Week Healthy Lifestyle Workplace Intervention is Associated with Improvement in Heart Rate Profile Independent of Weight Changes or Traditional Metabolic Risk Factors
Authors: Ehimen Aneni, Bryan Vo, Ebenezer Oni, Lara R Roberson, Maribeth Rouseff, Henry Guzman, Thinh H Tran, Sankalp Das, Doris Brown, Joann Santiago-Charles, Teresa C Ochoa, Joseph Mora, Cynthia Gilliam, Virginia Lehn, Josette Bou-Khalil, Beatriz Castillo, Janisse Post, Theodore Feldman, Arthur S Agatston, Emir Veledar, Khurram Nasir
Journal: Circulation (2014)

Introduction:  Several heart rate (HR) during exercise, such as heart rate recovery (HRR) and Chronotropic index (CI), have been associated with increased risk of cardiovascular disease (CVD) and CVD mortality. However, only a handful of studies have examined the effects of improving physical fitness on changes in HR profile. We assessed the effects of improving physical fitness on HR profile in a high risk population free from known CVD who were undergoing an intensive lifestyle intervention program.   Methods:  The study population included 204 participants of a lifestyle intervention program who had at least 2 metabolic risk factors at baseline. The program focused on improving nutrition, physical fitness and promotion of healthy lifestyle using a multi-disciplinary approach including one-on-one counseling and fitness training throughout the 12 week program with close supervision. Participants underwent exercise stress testing at baseline and at 12 weeks.   Results:  Over the 12 week period there was a significant increase in metabolic equivalents (([[Unable to Display Character: ∆]]METS) mean difference = 2.1 95%CI: 1.9, 2.4 p   Conclusion:  Improvement in HR profiles can be achieved in a high risk population through programs that focus on physical fitness even if there is no improvement in weight, and regardless of baseline cardiometabolic risk. Improvement in HR profiles, not just weight loss, should be included in criteria for measuring success of similar interventions.
Running on Exhaustion: Pathogen Burden, Immune Dysregulation, and Endothelial Activation After Coronary Artery Bypass Graft Surgery
Authors: Pamela S. Miller
Journal: Circulation (2009)

Abstract #906 Pamela S. Miller, Lorraine S. Evangelista, Joyce Newman Giger, Otoniel Martinez-Maza, Univ of California, Los Angeles, Los Angeles, CA; Teresita Corvera-Tindel, VA Greater Los Angeles Health Care System, Los Angeles, CA; Fardad Esmailian, Lynn V. Doering, Univ of California, Los Angeles, Los Angeles, CA Pamela S. Miller, 2009 Finalist and Presenting Author
Elevation of Pretreatment Carcinoembryonic Antigen Level as a Prognostic Factor for Colon Cancer
Authors: Ramzi Amri, David L. Berger
Journal: JAMA Surgery (2015)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Surgery HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Surgery journal
The Tyrosine Kinase Abl-Related Gene ARG Is Fused toETV6 in an AML-M4Eo Patient With a t(1;12)(q25;p13): Molecular Cloning of Both Reciprocal Transcripts
Authors: Giovanni Cazzaniga, Sabrina Tosi, Alessandra Aloisi, Giovanni Giudici, Maria Daniotti, Pietro Pioltelli, Lyndal Kearney, Andrea Biondi
Journal: Blood (1999)
What Grown-ups Do
Authors: Cortney Davis
Journal: JAMA (2000)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Cancer of the Cervix of the Uterus in Hybrid Mice Following Long-Continued Administration of Estrogen
Authors: Edgar Allen, W. U. Gardner
Journal: Cancer Research (1941)

2 strains of mice (one is C57 which is definitely resistant to mammary cancer but has poor tolerance for estrogenic treatment and the other was CBA which has an incidence of 70% of spontaneous tumors in force bred animals but tolerates estrogen treatment well) were hybridized in the hope that the F1 generation would tolerate estrogenic treatment well and to determine the incidence of hypophysial and mammary tumors.  The resulting offsprings were grouped into 2:  CC1 consisting of 24 females and CC2 consisting of 20 females; both groups received estrogenic treatment for more than 1 year.  Majority of the animals received 16.6 mg/week estradiol benzoate and some received as much as 50 mg/week starting at 28-56 days of age and maintained at the same level throughout the animals lives.  Similar number of untreated hybrid mice served as controls.  Lesions and cervical carcinomas appeared in 15 of the 24 mice (62%) and 10 of 20 (50%) mice which survived the treatment for more than 1 year.  The lower incidence of cervical lesions in the CC2 group was probably due to the 60% incidence of mammary tumors which occurred at an earlier age than the cervical lesions.  Genetic factors involved in mammary cancer had little effect in the carcinogenesis of the cervix uteri.  No cervical lesions appeared in either group before 400 days of age and none appeared in the CC1 group before 450 days of age.  It is concluded that with this hybrid stock chronic estrogenic stimulation at this level usually requires longer than 400 days for the appearance of cervical lesions and that estrogen is a very important factor in cervical carcinogenesis.
116. Members of Adenovirus Subgroup B Utilize CD80 (B7.1) and CD86 (B7.2) as Primary Cellular Attachment Receptors
Authors: Toshiaki Kikuchi, Sita Andarini, Toshihiro Nukiwa
Journal: Molecular Therapy (2004)

OX40 ligand (OX40L), the ligand for OX40 on T cells, is essential for induction of antigen-specific T-cell responses, a critical component of the immune response to tumors. In this study, we examined in vivo transduction of tumors with recombinant adenovirus (Ad) vector of mouse OX40L (AdOX40L) to elicit therapeutic antitumor immunity in three different murine tumor models in two strains of mice. In the Colon-26 (H-2d, colon cancer) and the B16 (H-2b, melanoma) murine models, intratumoral injection of 109 pfu AdOX40L to established subcutaneous tumors resulted in sustained tumor regression. Intratumoral injection of AdOX40L also significantly suppressed growth of weakly immunogenic Lewis lung carcinoma (H-2b) established tumors. In vivo AdOX40L modification of tumors to express OX40L elicited tumor-specific cytolytic T lymphocytes responses. These results support the concept that in vivo transduction of tumors with a recombinant OX40L Ad vector may be a useful strategy to help develop cancer immunotherapy.
Factors Associated With Major Bleeding Events
Authors: Shaun G. Goodman, Daniel M. Wojdyla, Jonathan P. Piccini, Harvey D. White, John F. Paolini, Christopher C. Nessel, Scott D. Berkowitz, Kenneth W. Mahaffey, Manesh R. Patel, Matthew W. Sherwood, Richard C. Becker, Jonathan L. Halperin, Werner Hacke, Daniel E. Singer, Graeme J. Hankey, Gunter Breithardt, Keith A.A. Fox, Robert M. Califf
Journal: Journal of the American College of Cardiology (2013)
Criminalization of psychotherapist-patient sex
Authors: L H Strasburger, L Jorgenson, R Randles
Journal: American Journal of Psychiatry (1991)

Legislative enactment of criminal penalties for psychotherapists' sexual contact with their patients is pending in several states. The arguments in favor of criminalization are that it serves as a deterrent, offers retribution, provides redress when other avenues are blocked, deals with unlicensed psychotherapists, makes victims' assistance funds available, and provides due process protection against false accusations. In opposition to criminalization are the arguments that civil and administrative measures already exist to deal with the problem, it may have a chilling effect on the reporting of misconduct, it may void malpractice insurance, it makes guilty psychotherapists place themselves in jeopardy if they acknowledge their wrongdoing in attempting to make amends, it removes control of the legal process from the victim, it fails to offer rehabilitation, and it singles out psychotherapists from other fiduciaries for more stringent treatment. APA district branches inevitably will be called on to take positions with regard to legislation criminalizing sexual exploitation of patients. The current public outrage over patient victimization, however appropriate it may be, appears to make it difficult to publicly justify anything other than support for criminalization.
Lessons in Friendship
Authors: Susan Adelman
Journal: JAMA (2002)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Glucocorticosteroids for sepsis: systematic review with meta-analysis and trial sequential analysis
Authors: M. Volbeda, J. Wetterslev, C. Gluud, J. G. Zijlstra, I. C. C. van der Horst, F. Keus
Journal: Intensive Care Medicine (2015)

Glucocorticosteroids (steroids) are widely used for sepsis patients. However, the potential benefits and harms of both high and low dose steroids remain unclear. A systematic review of randomised clinical trials with meta-analysis and trial sequential analysis (TSA) might shed light on this clinically important question.A systematic review was conducted according to a published protocol and The Cochrane Handbook methodology including meta-analyses, TSA of randomised clinical trials, and external validity estimation (GRADE). Randomised clinical trials evaluating steroids were included for sepsis patients (systemic inflammatory response syndrome, sepsis, severe sepsis or septic shock) aged >18 years. Cochrane Central Register of Controlled Trials (CENTRAL), PubMed/Medline, Embase, Web of Science and Cinahl were searched until 18 February 2015. No language restrictions were applied. Primary outcomes were mortality at longest follow-up and serious adverse events.A total of 35 trials randomising 4682 patients were assessed and reviewed in full text. All trials but two had high risk of bias. No statistically significant effect was found for any dose of steroids versus placebo or no intervention on mortality at maximal follow-up [relative risk (RR) 0.89; TSA adjusted confidence interval (CI) 0.74-1.08]. Two trials with low risk of bias also showed no statistically significant difference (random-effects model RR 0.38, 95% CI 0.06-2.42). Similar results were obtained in subgroups of trials stratified according to high (>500 mg) or low (≤ 500 mg) dose hydrocortisone (or equivalent) (RR 0.87; TSA-adjusted CI 0.38-1.99; and RR 0.90; TSA-adjusted CI 0.49-1.67, respectively). There were also no statistically significant effects on serious adverse events other than mortality (RR 1.02; TSA-adjusted CI 0.7-1.48). The effects did not vary according to the degree of sepsis. TSA showed that many more randomised patients are needed before definitive conclusions may be drawn.Evidence to support or negate the use of steroids in any dose in sepsis patients is lacking. The results of ongoing and future well-designed, large randomised clinical trials are needed.
Annular Height-to-Commissural Width Ratio of Annulolasty Rings In Vivo
Authors: Tomasz A. Timek, Julie R. Glasson, David T. Lai, David Liang, George T. Daughters, Neil B. Ingels, D. Craig Miller
Journal: Circulation (2005)

Background— A “saddle-shaped” mitral annulus with an optimal ratio between annular height and commissural diameter may reduce leaflet and chordal stress and is purported to be conserved across mammalian species. Whether annuloplasty rings maintain this relationship is unknown. Methods and Results— Twenty-three adult sheep underwent implantation of radiopaque markers on the left ventricle and mitral annulus. Eight animals underwent implantation of a Carpentier-Edwards Physio ring, 7 underwent a Medtronic Duran flexible ring, and 8 served as controls. Animals were studied with biplane videofluoroscopy 7 to 10 days postoperatively. Annular height and commissural width (CW) were determined from 3D marker coordinates, and annular height:CW ratio (AHWCR) was calculated. Annular height was similar in Control and Duran animals but significantly lower in the Physio group at end diastole (8.4±3.8, 6.7±2.3, and 3.4±0.6 mm, respectively, for Control, Duran, and Physio; ANOVA=0.005) and at end systole (14.5±6.2, 10.5±5.5, and 5.8±2.5 mm, respectively, for Control, Duran, and Physio; ANOVA=0.004). Both ring groups reduced CW significantly relative to Control. AHCWR did not differ between Control and Duran but was lower in Physio (23±11%, 24±7%, and 12±2% at end diastole and 42±17%, 37±17%, and 21±10% at end systole, respectively, for Control, Duran, and Physio, respectively; ANOVA &lt;0.05 for both). Conclusions— Mitral annular height and AHWCR of the native valve were unchanged by a Duran ring, whereas the Physio ring led to a lower AHWCR. Theoretically, such a flexible annuloplasty ring may provide better leaflet stress distribution by maintaining normal AHWCR.
Progressive Ataxia and Palatal Tremor
Authors: José Rafael P. Zuzuárregui, Samuel A. Frank
Journal: JAMA Neurology (2015)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Neurology HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Neurology journal
Acting and Clinical Empathy
Authors: Don R Lipsitt
Journal: JAMA (2005)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Swelling of Metastatic Tumors with High-Dose Interleukin Therapy
Authors: S.H. Goey, H.J. Voerman, R.J.M. Strack van Schijndel, J.J.M. van der Hoeven, J. Wagstaff, L.G. Thijs, H.M. Pinedo
Journal: New England Journal of Medicine (1988)