THE EFFICACY OF MAINTENANCE DOSES OF DIGITALIS IN PREVENTING THE RECURRENCE OF CONGESTIVE HEART FAILURE
Authors: J S LaDUE, S B CARTER
Journal: Annals of Internal Medicine (1947)

Article1 December 1947THE EFFICACY OF MAINTENANCE DOSES OF DIGITALIS IN PREVENTING THE RECURRENCE OF CONGESTIVE HEART FAILUREJOHN S. LADUE, M.D., Ph.D., F.A.C.P., SANDY B. CARTER, M.D.JOHN S. LADUE, M.D., Ph.D., F.A.C.P.Search for more papers by this author, SANDY B. CARTER, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-27-6-923 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptINTRODUCTIONSeveral investigators1have demonstrated that patients with heart disease associated with auricular fibrillation develop congestive heart failure when digitalis is withheld. Katz, Sokolow, Weinberg and Plaut2were the first investigators to study the effect of maintenance doses offolia digitalison the circulation of patients with chronic congestive heart failure associated with regular sinus rhythm. They presented studies on four patients who showed a prompt increase in the venous pressure, circulation time, and weight when digitalis was withheld and who also developed clinical evidence of congestive heart failure. We had begun a similar study several months before the publication...Bibliography1. WITHERING W: An account of the foxglove and some of its medical uses; with practical remarks on dropsy and other diseases, 1785, M. Swinney, Birmingham. MACKENZIE, J.: Digitalis, Heart, 1911, ii, 273. EGGLESTON, C.: Clinical observations on the duration of digitalis action, Jr. Am. Med. Assoc., 1912, lix, 1352. EGGLESTON, C.: Digitalis dosage, Arch. Int. Med., 1915, xvi, 1. PARDEE, H.: Notes on digitalis medication. 1. The rate of disappearance of digitalis from the body. 2. The therapeutic dose of tincture of digitalis, Jr. Am. Med. Assoc., 1919, lxxiii, 1822. ROBINSON, G.: The rapidity and persistence of the action of digitalis on hearts showing auricular fibrillation, Am. Jr. Med. Sci., 1920, clix, 121. CUSHNY, A.: The action and uses of digitalis and its allies, 1925, Longmans, Green and Co., London. GOLD, H., and DEGRAFF, A.: Studies on digitalis in ambulatory patients. II. The elimination of digitalis in man, Jr. Clin. Invest., 1929, vi, 613. GOLD, H., and DEGRAFF, A.: Studies on digitalis in ambulatory patients. IV. Newer principles in digitalis dosage, Jr. Am. Med. Assoc., 1930, xcv, 1237. STROUD, W., and VANDER VEER, J.: A six year study of the clinical efficacy of various digitalis preparations, Jr. Am. Med. Assoc., 1937, cix, 1808. Google Scholar2. KATZSOKOLOWWEINBERGPLAUT LMHJ: Digitalis in the prevention of recurrent failure in patients with sinus rhythm, Ann. Int. Med., 1942, xvi, 427. Google Scholar3. PEABODY F: Relation of the vital capacity of the lungs to the clinical condition of patients with heart disease, Jr. Am. Med. Assoc., 1917, lxix, 1954. CrossrefGoogle Scholar4. KOCH E: Die Stromgeschwindigkeit des Blutes, Deutsch. Arch. f. klin. Med., 1922, cxl, 39. BLUMGART, H.: The velocity of blood flow in health and disease, Medicine, 1931, x, 1. BLUMGART, H., and WEISS, S.: Clinical studies on velocity of blood flow. XI. Pulmonary circulation time, the minute volume flow through lungs, and the quantity of blood in the lungs, Jr. Clin. Invest., 1928-29, vi, 103. Google Scholar5. STEWARTDEITRICKCRANEWHEELER HJNC: Action of digitalis in uncompensated heart disease, Arch. Int. Med., 1938, lxii, 569. CrossrefGoogle Scholar6. LADUEFAHR JSG: The effect of the intravenous administration of Lanatoside C upon the output, diastolic volume, and mechanical efficiency of the failing human heart, Am. Heart Jr., 1943, xxv, 344. CrossrefGoogle Scholar7. BURWELLNEIGHBORSREGEN CDE: The effect of digitalis upon the output of the heart in normal man, Jr. Clin. Invest., 1927, v, 125. CrossrefGoogle Scholar8. RAYLADUE TJS: The intravenous administration of Lanatoside C to patients taking maintenance doses of folia digitalis up to the date of hospitalization with recurrent congestive heart failure, Am. Heart Jr., 1945, xxx, 335. CrossrefGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: *Received for publication February 20, 1947.From the Department of Medicine, Louisiana State University School of Medicine, and the Charity Hospital of Louisiana at New Orleans. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byTherapie der Herzinsuffizienz 1 December 1947Volume 27, Issue 6Page: 923-928KeywordsAtrial fibrillationCardiovascular therapyHeart failureHospital medicineLongitudinal studies ePublished: 1 December 2008 Issue Published: 1 December 1947 PDF downloadLoading ...