tbuckley/cabot-search huggingface dataset:
Production of anti-B monoclonal antibodies (DBB.42, DBA.44, DNA.7, and DND.53) reactive on paraffin-embedded tissues with a new B-lymphoma cell line grafted into athymic nude mice
Authors: T al Saati, S Caspar, P Brousset, S Chittal, P Caveriviere, H Hounieu, N Dastugue, JB Idoipe, J Icart, C Mazerolles
Journal: Blood (1989)
Reduced Risk for Inappropriate Implantable Cardioverter-Defibrillator Shocks With Dual-Chamber Therapy Compared With Single-Chamber Therapy
Authors: Christof Kolb, Marcio Sturmer, Peter Sick, Sebastian Reif, Jean Marc Davy, Giulio Molon, Jörg Otto Schwab, Giuseppe Mantovani, Dan Dan, Carsten Lennerz, Alberto Borri-Brunetto, Dominique Babuty
Journal: JACC Heart Failure (2014)

The OPTION (Optimal Anti-Tachycardia Therapy in Implantable Cardioverter-Defibrillator Patients Without Pacing Indications) trial sought to compare long-term rates of inappropriate shocks, mortality, and morbidity between dual-chamber and single-chamber settings in implantable cardioverter-defibrillators (ICDs) patients.The use of dual-chamber ICDs potentially allows better discrimination of supraventricular arrhythmias and thereby reduces inappropriate shocks. However, it may lead to detrimental ventricular pacing.This prospective multicenter, single-blinded trial enrolled 462 patients with de novo primary or secondary prevention indications for ICD placement and with left ventricular ejection fractions ≤40% despite optimal tolerated pharmacotherapy. All patients received atrial leads and dual-chamber defibrillators that were randomized to be programmed either with dual-chamber or single-chamber settings. In the dual-chamber setting arm, the PARAD+ algorithm, which differentiates supraventricular from ventricular arrhythmias, and SafeR mode, to minimize ventricular pacing, were activated. In the single-chamber setting arm, the acceleration, stability, and long cycle search discrimination criteria were activated, and pacing was set to VVI 40 beats/min. Ventricular tachycardia detection was required at rates between 170 and 200 beats/min, and ventricular fibrillation detection was activated above 200 beats/min.During a follow-up period of 27 months, the time to the first inappropriate shock was significantly longer in the dual-chamber setting arm (p = 0.012, log-rank test), and 4.3% of patients in the dual-chamber setting group compared with 10.3% in the single-chamber setting group experienced inappropriate shocks (p = 0.015). Rates of all-cause death or cardiovascular hospitalization were 20% for the dual-chamber setting group and 22.4% for the single-chamber setting group and satisfied the pre-defined margin for equivalence (p < 0.001).Therapy with dual-chamber settings for ICD discrimination combined with algorithms for minimizing ventricular pacing was associated with reduced risk for inappropriate shock compared with single-chamber settings, without increases in mortality and morbidity. (Optimal Anti-Tachycardia Therapy in Implantable Cardioverter-Defibrillator [ICD] Patients Without Pacing Indications [OPTION]; NCT00729703).
Abstract 21633: Relationship Between Descriptors of Coronary Atherosclerosis by Coronary Ct Angiography and Quantitative Myocardial Perfusion as Assessed by Hybrid PET/CT Imaging
Authors: Masanao Naya, Ron Blankstein, Arkadiusz Sitek, Julie Williams, Jolene Fantony, Sharmila Dorbala, Marcelo Di Carli
Journal: Circulation (2010)

Background: Although the relationship between coronary stenosis and myocardial perfusion is well established, little is known about the contribution of other anatomic descriptors of atherosclerosis burden to this relationship. Methods: We evaluated the per-vessel associations between athero burden and myocardial flow reserve (MFR) in 73 consecutive patients undergoing quantitative 82Rubidium myocardial perfusion PET and coronary CT angiography (CTA) imaging for the evaluation of known or suspected CAD. CTA descriptors of athero burden included the quantitative diameter stenosis (DS), plaque composition (calcified, non-calcified or mixed), summed stenosis score within each coronary artery (summed of all stenosis), total plaque length, and vessel remodeling index (<1.1; 1.1–1.29; or ≥1.3). MFR was defined as the ratio of peak stress over rest myocardial blood flow. Results: Coronary atherosclerosis was seen in 50 of 73 patients, and in 107 of 209 evaluable coronary arteries. In univariate analysis, regional...
Abstract 19280: Exposure to Low-Dose Ionizing Radiation from Cardiac Imaging among Patients with Myocardial Infarction in Canada: 10-Year Data from a Large Canadian Longitudinal Cohort
Authors: Patrick R Lawler, Jonathan Afilalo, Louise Pilote, Hugues Richard, Mark J Eisenberg
Journal: Circulation (2010)

Background: The use of cardiac imaging procedures involving low-dose ionizing radiation (LDIR) is becoming increasingly recognized as a source of significant radiation exposure. Data has emerged to...
Abstract 053: Cardioprotective Medication Use Among People with Unrecognized Myocardial Infarction: The REasons for Racial And Geographic Differences in Stroke Study
Authors: Emily B Levitan, Christopher Gamboa, Monika M Safford, Dana V Rizk, Todd M Brown, Elsayed Z Soliman, Paul Muntner
Journal: Circulation (2012)

Introduction: Evidence supports use of aspirin, beta-blockers, angiotensin converting enzyme inhibitors or angiotensin receptor blockers (ACEI/ARB), and statins for secondary prevention in people with myocardial infarction (MI). The prevalence of medication use among individuals who do not report having MI but with evidence of MI on electrocardiogram (ECG) is unknown. Methods: The REasons for Geographic And Racial Differences in Stroke (REGARDS) study has 30,239 participants; we analyzed cross-sectional data on 21,036 of the participants who had available 12-lead ECG data. Aspirin was assessed using self-report; other medications were assessed by pill-bottle review. Recognized MI (RMI) (n = 1,574, 7.5% of the population) was defined as self-reported history of MI. Unrecognized MI (UMI) (n = 949, 4.5% of the population) was defined as ECG abnormalities consistent with MI (using the Minnesota Code system) without self-reported history. We calculated prevalence of medication use, and among participants with UMI, we examined the correlates of medication use with prevalence ratios (PR) adjusted for age, race, and sex. Results: The prevalence of aspirin, beta-blocker, ACEI/ARB, and statin use in participants with UMI was substantially lower than in participants with RMI; participants with UMI had a somewhat higher prevalence than participants without MI (Figure). Among people with UMI, women and African-Americans were less likely to use aspirin (PR women compared to men = 0.76, 95% CI 0.66–l0.87; PR African-American compared to white participants = 0.82, 95% CI 0.71–0.96). Older individuals and those with diabetes were more likely to use all four medications. Conclusions: In this population, the prevalence of cardioprotective medication use among people with UMI was more like the prevalence among people without MI than those with RMI. People with UMI but not major MI risk factors were less likely to use cardioprotective medications.
Abstract 20683: Imaging Rage Expression In Mouse Model Of Myocardial Infarction
Authors: Yared Tekabe, Qing Li, Joane Luma, Geping Zhang, Ann Marie Schmidt, Ravi Ramasamy, Lynne Johnson
Journal: Circulation (2010)

Background and hypothesis: RAGE and its ligands have been implicated in pathogenesis of ischemia/reperfusion injury. We hypothesized that RAGE expression in ischemic myocardium can be imaged in mic...
Erectile Dysfunction as a Predictor of Cardiovascular Events and Death in Diabetic Patients With Angiographically Proven Asymptomatic Coronary Artery Disease
Authors: Carmine Gazzaruso, Sebastiano B. Solerte, Arturo Pujia, Adriana Coppola, Monia Vezzoli, Fabrizio Salvucci, Cinzia Valenti, Andrea Giustina, Adriana Garzaniti
Journal: Journal of the American College of Cardiology (2008)
Abstract 11148: Aging Impairs Endothelium-dependent Dilation Via Thiol-Oxidation in Coronary Arterioles in Smp 30 Deficiency Mice
Authors: Shinya Yamada, Shu-ichi Saitoh, Hiroyuki Mizukami, Hirofumi Machii, Yasuchika Takeishi
Journal: Circulation (2011)

Aging with oxidant stress is a major risk factor of coronary artery disease, however the underlying mechanisms have not been fully defined. Senescence marker protein 30 (SMP30) has been identified ...
Abstract 2015: Effect of Early Intensive Statin Therapy on Regression of Coronary Atherosclerosis in Patients with Acute Coronary Syndrome: The Multi-Center Randomized Trial Evaluated by Volumetric Intravascular Ultrasound Comparing Pitavastatin versus Atorvastatin (JAPAN-ACS study)
Authors: Takeshi Kimura, Takafumi Hiro, Takeshi Morimoto, Katsumi Miyauchi, Yoshihisa Nakagawa, Masakazu Yamagishi, Yukio Ozaki, Kazuo Kimura, Satoshi Saito, Tetsu Yamaguchi, Hiroyuki Daida, Masunori Matsuzaki
Journal: Circulation (2008)

A prior single center study reported that early lipid-lowering therapy with atorvastatin 20 mg/day in patients (pts) with acute coronary syndrome (ACS) significantly reduced coronary plaque volume (PV) of the non-culprit site by intravascular ultrasound (IVUS) evaluation. Effect of statins other than atorvastatin on PV has not been evaluated yet in the setting of ACS. A prospective, randomized open-label parallel group study with blinded endpoint evaluation was perfomed at 33 centers in Japan. Pts with ACS undergoing IVUS-guided percutaneous coronary intervention (PCI) were randomly assigned to receive either 4 mg/day of pitavastatin or 20 mg/day of atorvastatin within 72 hours after PCI. The primary endpoint was the percentage change in non-culprit coronary PV by IVUS from baseline to 8 –12 months follow-up. The study was powered to evaluate non-inferiority of pitavastatin to atorvastatin. Between November 2005 and October 2006, 307 pts (pitavastatin group 153 pts and atorvastatin group 154 pts) were enrolled; 252 pts (82%) had IVUS image qualified for evaluation both at baseline and at follow-up. Low-density lipoprotein cholesterol (LDL-C) decreased from 130.9±33.3mg/dL at baseline to 81.1±23.4mg/dL at 8 –12 months follow-up (p= 0.001) in the pitavastatin group and from 133.8±31.4mg/dL to 84.1±27.4mg/dL (p= 0.001) in the atorvastatin group. PV decreased from 49.8±28.8mm 3 to 41.6±25.0mm 3 (p= 0.001) in the pitavastatin group and from 63.9±33.9mm 3 to 53.3±31.7mm 3 (p= 0.001) in the atorvastatin group. Mean percentage change in PV was −16.9±13.9% and −18.1±14.2% (p=0.5) in the pitavastatin and atorvastatin group, respectively. Upper limit of the 95% confidence interval of the mean difference in percentage change in PV between the two groups (1.11% (−2.27 to 4.48)) did not exceed the pre-defined non-inferiority margin of 5%. There was no significant correlation between percent change in plaque volume and LDL-C at baseline or at follow-up. Early intensive statin therapy with 4mg/day of pitavastatin or 20mg/day of atorvastatin in Japanese patients with ACS resulted in remarkable regression of coronary PV. The effect of pitavastatin 4mg/day on coronary PV was similar to that of atorvastatin 20mg/day.
Risk Factors for Poor Survival after Hematopoietic Stem Cell Transplantation in Inherited Bone Marrow Failure Syndromes
Authors: Melanie E Kalbfleisch, Michaela Cada, Robert J. Klaassen, Conrad V Fernandez, Rochelle Yanofsky, Yves Pastore, John K. Wu, Mariana Silva, Jeffrey H. Lipton, Josee Brossard, Bruno Michon, Sharon Abish, MacGregor Steele, Roona Sinha, Mark J. Belletrutti, Vicky R Breakey, Lawrence Jardine, Lisa Goodyear, Lillian Sung, Joseph Bayene, Tal Schechter-Finkelstein, Bozana Zlateska, Yigal Dror
Journal: Blood (2014)
Insult to newborn immunity.
Authors: John Tibbetts
Journal: Environmental Health Perspectives (2003)

Research ArticleOpen AccessInsult to newborn immunity.is accompanied byIn vitro activation of cord blood mononuclear cells and cytokine production in a remote coastal population exposed to organochlorines and methyl mercury. John Tibbetts John Tibbetts Search for more papers by this author Published:1 December 2003https://doi.org/10.1289/ehp.111-a896bAboutSectionsPDF ToolsDownload CitationsTrack Citations ShareShare onFacebookTwitterLinked InReddit "Insult to newborn immunity.." Environmental Health Perspectives, 111(16), pp. A896–A897FiguresReferencesRelatedDetailsRelated articlesIn vitro activation of cord blood mononuclear cells and cytokine production in a remote coastal population exposed to organochlorines and methyl mercury.1 December 2003Environmental Health Perspectives Vol. 111, No. 16 December 2003Metrics About Article Metrics Publication History Originally published1 December 2003Published in print1 December 2003 Financial disclosuresPDF download License information EHP is an open-access journal published with support from the National Institute of Environmental Health Sciences, National Institutes of Health. All content is public domain unless otherwise noted. Note to readers with disabilities EHP strives to ensure that all journal content is accessible to all readers. However, some figures and Supplemental Material published in EHP articles may not conform to 508 standards due to the complexity of the information being presented. If you need assistance accessing journal content, please contact [email protected]. Our staff will work with you to assess and meet your accessibility needs within 3 working days.
AC220 (Quizartinib) Can Be Safely Combined With Conventional Chemotherapy In Older Patients With Newly Diagnosed Acute Myeloid Leukaemia: Experience From The AML18 Pilot Trial
Authors: Alan K. Burnett, David Bowen, Nigel Russell, Steven Knapper, Donald Milligan, Ann E. Hunter, Asim Khwaja, Richard E. Clark, Dominic Culligan, Helen Clark, Robert K. Hills
Journal: Blood (2013)
Trends in Prevalence of the Metabolic Syndrome—Reply
Authors: Robert J. Wong
Journal: JAMA (2015)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Abstract 4408: Using a Large Electronic Medical Record to Validate 4q25 Variants Conferring Risk for Atrial Fibrillation
Authors: Joshua C Denny, Marylyn D Ritchie, Dana C Crawford, Andrea Havens, Justin Weiner, Hiroshi Watanabe, Dawood Darbar, Prince Kannankeril, Jill Pulley, Melissa Basford, Jonathan L Haines, Dan R Masys, Dan M Roden
Journal: Circulation (2008)

Background : Genome-wide association studies, largely in research populations, have identified susceptibility single-nucleotide polymorphisms (SNPs) for a broad range of human diseases, including variants at 4q25 associated with atrial fibrillation (AF). However, no studies have evaluated the applicability of these data to practice-based settings. Methods : This study was conducted in the Vanderbilt DNA Databank, a repository that accrues 500 –900 new samples/week from routine outpatient blood draws, and included 37,335 samples as of June 2, 2008. The Databank is linked to a de-identified derivative of the electronic medial record (EMR), which includes data for the last 15 years on 1.4 million subjects. We used natural language processing techniques and billing code queries to extract AF cases and controls without AF from the first 10,000 subjects entering the Databank. Cases had AF recorded in the cardiologist report of an electrocardiogram (ECG). Controls had at least one ECG and no AF, other abnormal atrial rhythms, or atrioventricular nodal ablation in any portion of the EMR, including text documents, billing codes, and ECGs. We excluded subjects with heart transplants and non-Caucasian ethnicity. Subjects were genotyped at rs2200733 and rs10033464, both located at 4q25, previously associated with AF with odds ratios (ORs) of 1.75 and 1.42, respectively. Results : We identified 168 cases with AF and 1695 controls. The electronic algorithms had an accuracy of 98% for identifying cases and 100% for controls over a random sample of 100 subjects each. The minor allele frequencies (MAF) for rs2200733 were 0.1419 for cases and 0.1032 for controls; the MAF for rs10033464 were 0.1019 for cases and 0.908 for controls. rs2200733 was significantly associated with AF (OR [95% confidence interval], 1.44 [1.01–2.03], p=0.04). The effect of rs10033464 on AF was not significant (OR, 1.14 [0.78 –1.67], p=0.52); however, power calculations indicate that 993 cases with AF were needed to replicate this effect. Conclusion : This practice-based study replicated an association identified in research datasets between a 4q25 SNP and AF. These findings support the utility of Electronic Medical Records coupled to DNA collections as resources for genomic research.
Re: Marcus G. Cumberbatch, Matteo Rota, James W.F. Catto, Carlo La Vecchia. The Role of Tobacco Smoke in Bladder and Kidney Carcinogenesis: A Comparison of Exposures and Meta-analysis of Incidence and Mortality Risks. Eur Urol 2016;70:458–66
Authors: Wentao Liu, Xiaokun Zhao, Zhaohui Zhong
Journal: European Urology (2015)
QT interval and SIDS.
Authors: D P Southall
Journal: Circulation (1983)

Digoxin-Verapamil Interaction -Is It Mutual?To the Editor:Reading the interesting article by Klein et al.' concerning the verap- amil-induced inhibition of digoxin clearance, one might wonder wheth- er digoxin similarly inhibits verapamil.The digoxin-verapamil interaction closely resembles the quinidine- digoxin interaction, because with both drugs the interaction has been attributed mainly to reduced renal clearance of digoxin due to inhibition of the digoxin tubular secretory process in the presence of unchanged creatinine clearance.Interestingly, DiGregorio et al.2 showed that digoxin inhibits quini- dine in the rat kidney.Moreover, looking at the six published articles on i.v.verapamil disposition, one realizes that the elimination half-life was 110-300 minutes in patients who did not receive digoxin,t7 and 378 minutes in patients who concomitantly received digoxin (p < 0.05).Because high serum levels of verapamil may be as hazardous as high digoxin levels, the possibility of digoxin-induced inhibition in verap- amil clearance should be further explored.
Are we clear about the mechanisms by which biopsy evidence of interstitial fibrosis following cardiac transplantation helps predict late post-transplant coronary artery disease?∗∗Editorials published in the Journal of the American College of Cardiologyreflect the views of the authors and do not necessarily represent the views of JACCor the American College of Cardiology.
Authors: Ahvie Herskowitz, Aftab A Ansari
Journal: Journal of the American College of Cardiology (2002)
Distinct Phenotypic and Functional Immunological Alterations Characterize the Peripheral Blood Compartment of Patients with Diffuse Large B Cell Lymphoma (DLBCL).
Authors: M. Christina Cox, Raffaella La Scaleia, Sabrina Pelliccia, Arianna Di Napoli, Eleonora Alma, Simone Battella, Virginia Naso, Alessandra Porzia, Luigi Ruco, Maria Antonietta Aloe Spiriti, Vincenzo Ambrogi, Fabrizio Mainiero, Sergio Amadori, Bruno Monarca, Angela Santoni, Gabriella Palmieri
Journal: Blood (2012)
Naloxone infusion should have been started earlier
Authors: N Nichol, L Pieterse, T Beattie
Journal: BMJ (1996)

responders and responders, the statistical power of this analysis was low, and the authors' main conclusion is based on the responses of only 54 patients.We wonder how many of the 31 non-responders would have had to be unsatisfied with the operation to reverse the results of the statistical analysis.We suspect that it would not be many.
Is poor insight in psychotic disorders associated with poor performance on the Wisconsin Card Sorting Test? [published erratum appears in Am J Psychiatry 1996 Feb;153(2):270]
Authors: M J Cuesta, V Peralta, F Caro, J de Leon
Journal: American Journal of Psychiatry (1995)

The purpose of this study was to test whether poor insight in patients with psychotic disorders is correlated with their performance on the Wisconsin Card Sorting Test.The subjects included 52 psychotic patients (35 of whom had schizophrenia) given diagnoses according to DSM-III-R criteria. Their scores on the Wisconsin Card Sorting Test (number of categories and perseverative responses) were compared with those on three items measuring poor insight: lack of feeling ill, lack of insight, and uncooperativeness.None of the six correlations between scores on the two measures of the neuropsychological test and the three items measuring insight was significant.In spite of its limitations, this study suggests that poor insight may not be associated with poor performance on the Wisconsin Card Sorting Test.
The inheritance of schizophrenia spectrum disorders: a reanalysis of the Danish adoptee study data
Authors: P A Lowing, A F Mirsky, R Pereira
Journal: American Journal of Psychiatry (1983)

Rosenthal and colleagues earlier compared the frequency of schizophrenia spectrum disorders in two groups of persons adopted in infancy or early childhood: those with a psychotic parent (index group) and those whose biological parents had never had a psychiatric diagnosis or treatment (control group). They found significantly more disorder in the index group. Reanalysis of the original material using DSM-III and stricter exclusionary criteria applied to the parents yielded three times as many schizophrenia spectrum disorders in the index as in the control group. This difference remained statistically significant, supporting the operation of genetic factors in the transmission of the traits comprising the schizophrenic spectrum of disorders.