tbuckley/cabot-search huggingface dataset:
Dehydroepiandrosterone Sulfate Does Not Predict Cardiovascular Death in Postmenopausal Women
Authors: Elizabeth Barrett-Connor, Deborah Goodman-Gruen
Journal: Circulation (1995)

Background High levels of dehydroepiandrosterone sulfate (DHEAS) appear to be associated with a reduced risk of fatal cardiovascular disease (CVD) in men. We examined the association between baseline DHEAS levels and the 19-year CVD and ischemic heart disease (IHD) mortality rates in 942 postmenopausal women free of known heart disease at baseline. Methods and Results The 199 CVD deaths and 102 IHD deaths were not related to baseline DHEAS levels. DHEAS was not related to body mass index, fasting plasma glucose, or family history of coronary heart disease, but significantly higher DHEAS levels were found in women who had elevated total or HDL cholesterol or blood pressure, were current smokers, or were nonusers of estrogen replacement therapy. After we adjusted for age, cholesterol, blood pressure, smoking, estrogen replacement therapy, obesity, fasting plasma glucose, and family history of heart disease, the relative risk of fatal CVD and IHD was 1.11 (95% confidence interval, 0.81 to 1.23) and 0.92 (95% confidence interval, 0.85 to 1.17), respectively, for a 50-μg/dL decrease in DHEAS. Conclusions Although higher DHEAS levels were associated with several major CVD risk factors, they were unrelated to the risk of fatal CVD in women.
Case 1-1975
Authors: Ronald A. Arky, Kilmer S. McCully
Journal: New England Journal of Medicine (1975)

Presentation of CaseA 29-year-old woman was admitted to the hospital because of an infected lesion on the right leg.The patient was the product of a consanguineous marriage. A cardiac murmur and hepatic enlargement had been detected at four months of age; at the age of six years a liver biopsy revealed cirrhosis. Intermittent peripheral edema and ascites had been present for 18 months before admission, and spironolactone and hydrochlorothiazide were prescribed. An upper gastrointestinal series eight months before entry showed no esophageal varices. Repeated electrocardiograms disclosed a pattern of left ventricular hypertrophy with possible myocardial infarction, and a . . .
Effects of noinionizing radiation on the central nervous system, behavior, and blood: a progress report.
Authors: D I McRee, J A Elder, M I Gage, L W Reiter, L S Rosenstein, M L Shore, W D Galloway, W R Adey, A W Guy
Journal: Environmental Health Perspectives (1979)

This paper presents a progress report on the U. S. research which has been designated as collaborative research with the Soviet Union to study the biological effects of nonionizing radiation on the central nervous system, behavior, and blood. Results of investigations to study the effects of microwaves on isolated nerves, synaptic function, transmission of neural impulses, electroencephalographic recordings, behavior, and on chemical, cytochemical and immunological properties of the blood are presented. Specifically, the effects of microwave exposure on chick brain and cat spinal cords, on EEG patterns of rats, on behavioral of neonatal rats exposed during development, on behavior of adult rats, on behavior of rhesus monkeys and on the pathology, hematology, and immunology of rabbits will be reported in a summary format. Much of the information is new and has not been published previously.
Taming the chronic kidney disease epidemic: a global view of surveillance efforts
Authors: Jai Radhakrishnan, Giuseppe Remuzzi, Rajiv Saran, Desmond E. Williams, Nilka Rios-Burrows, Neil Powe, None for the CDC-CKD Surveillance Team, Katharina Brück, Christoph Wanner, Vianda S. Stel, None on behalf of the European CKD Burden Consortium, Sree K. Venuthurupalli, Wendy E. Hoy, Helen G. Healy, Anne Salisbury, Robert G. Fassett, None on behalf of the CKD.QLD group, Donal O'Donoghue, Paul Roderick, Seiichi Matsuo, Akira Hishida, Enyu Imai, Satoshi Iimuro
Journal: Kidney International (2014)
Intensive insulin therapy reduced long-term risk for incident hypertension in type 1 diabetes
Authors: Apostolos Tsapas
Journal: Annals of Internal Medicine (2009)

ACP Journal Club17 February 2009Intensive insulin therapy reduced long-term risk for incident hypertension in type 1 diabetesApostolos Tsapas, MD, PhDApostolos Tsapas, MD, PhDOxford Centre for Diabetes Endocrinology and Metabolism, Oxford, England, UK, Aristotle University Thessaloniki, Thessaloniki, Greece (A.T.)Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-150-4-200902170-02012 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail Source Citationde Boer IH, Kestenbaum B, Rue TC, et al. Insulin therapy, hyperglycemia, and hypertension in type 1 diabetes mellitus. Arch Intern Med. 2008;168:1867-73. https://pubmed.ncbi.nlm.nih.gov/18809813Clinical Impact RatingsGIM/FP/GP: Endocrinology: References1 Writing Team for the DCCT/EDIC Research Group. Sustained effect of intensive treatment of type 1 diabetes mellitus on development and progression of diabetic nephropathy: the Epidemiology of Diabetes Interventions and Complications (EDIC) study. JAMA. 2003;290:2159-67. [PMID: 14570951] Google Scholar2 Holman RR, Paul SK, Bethel MA, Matthews DR, Neil HA. 10-year follow-up of intensive glucose control in type 2 diabetes. N Engl J Med. 2008;359:1577-89. [PMID: 18784090] Google Scholar Author, Article, and Disclosure InformationAuthors: Apostolos Tsapas, MD, PhDAffiliations: Oxford Centre for Diabetes Endocrinology and Metabolism, Oxford, England, UK, Aristotle University Thessaloniki, Thessaloniki, Greece (A.T.)This article was published at Annals.org on 3 February 2009. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 17 February 2009Volume 150, Issue 4Page: JC2-12KeywordsCohort studiesDrugsExcretionHazard ratioHyperglycemiaHypertensionInsulinRenal diseasesRetinopathyType 1 diabetes ePublished: 17 February 2009 Issue Published: 17 February 2009 Copyright & PermissionsCopyright © 2009 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Sialic acids of human large bowel mucosa: o-acylated variants in normal and malignant states.
Authors: C M Rogers, K B Cooke, M I Filipe
Journal: Gut (1978)

Five sialic acid variants have been demonstrated in normal, 9transitional9, and tumour extracts of human large bowel mucosa by thin-layer chromatography. Two-dimensional thin-layer chromatography, with intermediate alkaline hydrolysis, confirmed that the variants were N-acetyl neuraminic acids with additional O-acylation. Cases studied so far show changes in the proportions of these variants in malignancy.
Protection Against Atopic Diseases by Measles—A Rash Conclusion?
Authors: James E. Gern
Journal: JAMA (2000)

MAJOR QUESTION FACING MODERN MEDICINE IS WHY atopic diseases such as asthma, allergic rhinitis, and atopic dermatitis, which have in common the overproduction of allergen-specific or total IgE, are increasing in prevalence. Atopic diseases are influenced by genetic predisposition and environmental exposures. However, since the spontaneous genetic mutation rate is quite slow, it is clear that changes in the environment are responsible for the increased prevalence of atopic diseases. But which environmental factor(s) is the culprit? Many theories, based on epidemiologic or experimental data, have been advanced, including improved hygiene 1,2 ; changes in diet 3,4 ; changes in intestinal flora due to increased use of antibiotics 5 and altered patterns of infant feeding 6 ; greater exposure to allergens 7 ; obesity and reduced physical activity 8 ; and changes in the prenatal environment. 9 One interesting theory is that the reduction of early childhood infectious diseases, due to widespread vaccination of children or increased use of antibiotics, has led to an increased prevalence of allergic diseases. This theory, known as the “hygiene hypothesis,” was advanced by Stra
Medicine and the US Embargo Against Cuba
Authors: Anthony F. Kirkpatrick
Journal: JAMA (1996)

<h3>To the Editor.</h3> —I wholeheartedly agree with Dr Chelala<sup>1</sup>that the US and Cuban governments should enter into negotiations focused on supplying food and medicine to the island nation. His article is well documented. However, an even stronger case could be made using data independent of Cuban sources. The leverage exerted by the United States through the enactment of the Cuban Democracy Act of 1992, which limits Cuba's access to medicines worldwide, is immense. About half of all new patented drugs that have reached the status of world-class since 1975 are produced by US drug companies.<sup>2</sup>In addition, the act restricts the sale of medicines from US international subsidiaries by requiring that the president of the United States first certify, through on-site inspections approved by the president, that all the components of a given shipment of medicines were used for the purpose intended.<sup>3</sup>This means that the
Blockage of VEGF-Induced Angiogenesis by Preventing VEGF Secretion
Authors: Meit Björndahl, Renhai Cao, Anna Eriksson, Yihai Cao
Journal: Circulation Research (2004)

Vascular endothelial growth factor (VEGF)/vascular permeability factor is one of the most frequently expressed angiogenic factors in several pathological tissues. Development of VEGF antagonists has become an important approach in the treatment of angiogenesis-dependent diseases. Here we describe a novel anti-VEGF strategy by preventing the secretion of VEGF. We utilize the fact that placenta growth factor (PlGF)-1, a member of the VEGF family lacking detectable angiogenic activity, preferentially forms intracellular heterodimers with VEGF in cells coexpressing both factors. We constructed a retroviral vector containing human PlGF-1 or VEGF with a C-terminal KDEL sequence, which is a mammalian retention signal for the endoplasmic reticulum. Transduction of murine Lewis lung carcinoma cells with the retro-hPlGF-1-KDEL construct almost completely abrogated tumor growth. Consistent with the dramatic antitumor effect, most mouse VEGF molecules remained as intracellular mVEGF/hPlGF-1 heterodimers, and only a negligible amount of mVEGF homodimers were secreted. As a result, in hPlGF-1-KDEL-expressing tumors, blood vessels remained at very low numbers and lacked branching and capillary networks. Gene transfer of a hVEGF-KDEL construct into tumor cells likewise produced a dramatic antitumor effect. Thus, our study provides a novel antiangiogenic approach by preventing the secretion of VEGF.
Epicardial delivery of collagen patches with adipose-derived stem cells in rat and minipig models of chronic myocardial infarction
Authors: Miriam Araña, Juan J. Gavira, Estefanía Peña, Arantxa González, Gloria Abizanda, Myriam Cilla, Marta M. Pérez, Edurne Albiasu, Natalia Aguado, Mayte Casado, Begoña López, Susana González, Mario Soriano, Cristina Moreno, Juana Merino, José M. García-Verdugo, Javier Díez, Manuel Doblaré, Beatriz Pelacho, Felipe Prosper
Journal: Biomaterials (2013)
Severe Proliferative Diabetic Retinopathy
Authors: Ioannis K Petropoulos, John X Koliopoulos
Journal: New England Journal of Medicine (2007)

A 44-year-old woman with a 20-year history of type 1 diabetes mellitus presented with progressive visual loss over a period of 3 months in both eyes. She had no prior eye examinations, and on examination at our hospital her corrected visual acuity was 20/400 in the right eye and 20/40 in the left eye. She reported arterial hypertension, heavy smoking, and foot ulcers. Dilated ophthalmoscopy, performed at the first visit (Panels A and B), and red-free photographs (Panels C and D) and fluorescein angiography (Panels E and F), performed a week later, revealed severe, bilateral proliferative diabetic retinopathy with significant . . .
FUNGI IN NAILS.
Authors: MARGARET M. WALSHE, MARY P. ENGLISH
Journal: British Journal of Dermatology (1966)

Journal Article FUNGI IN NAILS. Get access MARGARET M. WALSHE, M.B., B.S., M.R.C.P., MARGARET M. WALSHE, M.B., B.S., M.R.C.P. Bristol General Hospital, Bristol, 1 Search for other works by this author on: Oxford Academic Google Scholar MARY P. ENGLISH, M.Sc. MARY P. ENGLISH, M.Sc. Bristol General Hospital, Bristol, 1 Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 78, Issue 4, 1 April 1966, Pages 198–207, https://doi.org/10.1111/j.1365-2133.1966.tb12205.x Published: 01 April 1966
Antipyrin in Sunstroke
Authors: G. A. Harris
Journal: BMJ (1887)

NI~~~jbtS~~~l;, ~tJIol t96, 4i881. .)t11stom,'there wereweIl pharked respiratoity undlatbion; ini the pGo roing of the right radial artery .. • -The destrctive tpeumonia which follows pressure on the bronchus ws eeerved in At of the twenty cases.This destrcutive pneumonia may be mistaken 'for malignant disease of, the lung, or fo ordinary ,phthisis, in one neOoply an aneurysm, involving the extra-periOardiac per- 4ion of the 'Asceniding aorta, had compressed the right brbnehus, and .; led toionsolidatioh of the upper lobe of the :right lung.h Diri'life the patient, & woman, had suffered from haemoptysis, slight tFidor and exhaustion, with marked cedema of the head, neck, and
Duffy Antigen Polymorphisms Do Not Alter Progression of HIV in African Americans in the MACS Cohort
Authors: K.C. Horne, X. Li, L.P. Jacobson, F. Palella, B.D. Jamieson, J.B. Margolick, J. Martinson, V. Turkozu, K. Visvanathan, I.J. Woolley
Journal: Cell Host & Microbe (2009)
Defects in Production of IL-15 and IL-18 by Mononuclear Cells and in CD16+ 56+ Cytotoxicity in Patients with Frequent Manifestations of Herpes Simplex Virus Infections
Authors: G.N. Drannik, V. Fesenkova, M. Derkach, E. Svidro, A.I. Kurchenko, L.M. DuBuske
Journal: Journal of Allergy and Clinical Immunology (2009)
How Many Authors Are Too Many?
Authors: Joseph S. Burkle
Journal: Annals of Internal Medicine (1990)

Letters and Corrections15 January 1990How Many Authors Are Too Many?Joseph S. Burkle, MDJoseph S. Burkle, MDSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-112-2-150_2 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the Editor:I have been reading the Annals with pleasure for many years. The article by Masur and colleagues (1) caught my attention because of the number of authors: There are 18! This must be a world's record for the number of authors (if one excludes the Government), but myGuinness Bookfails to list this as an item. These persons probably assisted in some way in the data collection, but can you imagine 18 authors trying to find some common phrasing for their ideas? The sad conclusion that I draw is that these "authors" need to list a...Reference1. MasurOgnibeneYarchoan HFR. CD4 counts as predictors of opportunistic pneumonias in human immunodeficiency virus (HIV) infection. Ann Intern Med. 1989;111:223-31. LinkGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 15 January 1990Volume 112, Issue 2Page: 150-150 Issue Published: 15 January 1990 PDF downloadLoading ...
Autologous and Aged Blood Donors
Authors: D. R. Avoy
Journal: JAMA (1987)

<h3>To the Editor.—</h3> In his editorial entitled "Autologous and Aged Blood Donors,"<sup>1</sup>Greenwalt quotes Perkins<sup>2</sup>as saying that the probability of a person needing a transfusion during the permissiblestorage period "has got to be very low." No data are provided. By using existing census data<sup>3</sup>and information about transfusion trends from the study of Friedman et al,<sup>4</sup>a more quantitative estimation of probability may be attempted. The logic is as follows: Approximately 4 million patients undergo transfusion in this country each year. Based on a total population of 236 million, the raw probability would be 1.66% that any individual would receive a transfusion in any year, or about one person in 60. Transfusions are not linearly distributed throughout the population. Persons younger than age 20 years represent 29.8% of the population and only 7.1% of the population receiving transfusions. Only 0.4% of this
Effect of green tea intake on the development of coronary artery disease
Authors: Junko Sano, Tomohiro Ogawa, Shigenobu Inami, Fumiyuki Ishibashi, Kentaro Okamatsu, Hiroyuki Kamon, Kouji Seimiya, Gen Takagi, Shunta Sakai, Atsunobu Nomura, Kyoichi Mizuno
Journal: Journal of the American College of Cardiology (2003)
Multi-Level Lumbar Baastrup Disease on F-18 FDG PET-CT
Authors: Linh Ho, Heidi Wassef, John Seto, Robert Henderson
Journal: Clinical Nuclear Medicine (2009)

We report the positron emission tomography-computed tomography appearance of Baastrup disease in the L2–L5 interspinous ligament region in a 79-year-old woman with a history of moderately differentiated lobular breast carcinoma. The patient is status post bilateral mastectomies, on tamoxifen for 2 and a half years, and currently in remission. Baastrup disease is characterized by close approximation and contact of adjacent spinous processes with resultant enlargement, flattening, and reactive sclerosis of apposing interspinous surfaces. Knowledge of the appearance of Baastrup disease on fluorodeoxyglucose positron emission tomography-computed tomography is important to avoid confusion with a spinous process lesion.
Spontaneous Rupture of the Spleen in Homozygous Hemoglobin C Disease
Authors: Mark Lipshutz
Journal: JAMA (1977)

SPONTANEOUS or pathologic rupture of the spleen has been reported in a variety of clinical conditions.<sup>1</sup>We report a case of spontaneous splenic rupture in a patient with homozygous hemoglobin C disease. <h3>Report of a Case</h3> A 25-year-old man was hospitalized with an 18-hour history of unremitting abdominal pain located below the umbilicus and associated with two episodes of syncope. There was no history of abdominal trauma, anemia, or jaundice. The patient was well developed and well nourished. Blood pressure was 120/80 mm Hg, without orthostatic change; pulse was 104 beats per minute and the temperature was 37.2 C. Pertinent physical findings included nonicteric sclerae, normal fundi, lungs that were clear to percussion and auscultation, and a hyperdynamic cardiac impulse with a grade 2/6 systolic precordial murmur. There was no hepatosplenomegaly, nor were any masses felt. Voluntary and involuntary muscular guarding with generalized rebound tenderness was present. Bowel sounds
What we need is better theory, not more data
Authors: Mike Anderson
Journal: Behavioral and Brain Sciences (2006)

Although I find Blair's case for arguing for the distinction between fluid cognitive functions and general intelligence less than compelling, I believe him. However, I also believe that what is required next is a theory of both general intelligence and fluid cognitive functions that articulates the distinction. In the absence of this, more data, particularly of the neuroscience variety, is likely to stall rather than advance progress.
Mianserin and agranulocytosis.
Authors: D A Curson, A S Hale
Journal: BMJ (1979)

An alcoholic woman who was admitted to hospital for detoxification was prescribed thyroxine because of hypothyroidism and mianserin to alleviate severe depression. After several weeks9 treatment she became unwell and was readmitted to hospital. Haematological examination indicated agranulocytosis. Further extensive investigations elicited no cause for this other than the mianserin, since no such disturbance has been reported for thyroxine after years of use. Thus mianserin is probably implicated in this case of agranulocytosis. Although the response may have been idiosyncratic, it highlights the need to monitor new drugs during the early phases of widespread use.
Abstract 4805: Distinctive phospho-proteome signatures in non-small cell lung carcinoma tumors
Authors: Yuhong Wei, Paul Taylor, Jiefei Tong, Nhu-An Pham, Ming Li, Devang Panchal, Christine To, Michael H. Chui, Ming-Sound Tsao, Thomas Kislinger, Michael F. Moran
Journal: Cancer Research (2012)

Abstract Non-small cell lung carcinoma (NSCLC) is a major, lethal cancer worldwide. Various molecular and cellular abnormalities are found in NSCLC, and an established theme is the alteration of protein phosphotyrosine (pY), as exemplified by elevated epidermal growth factor receptor (EGFR) activity recognized in a subset of NSCLC. In order to gain a broad perspective of pY-mediated signaling networks in NSCLC, mass spectrometry was used to analyze pY-containing peptides affinity purified from protease-digested xenograft tumors. Seventeen tumors representing the major NSCLC subtypes adenocarcinoma (ADC) and squamous cell carcinoma (SCC) were characterized. The major classes of pY proteins detected were cytoskeletal, protein kinases, and adhesion proteins. Pathways and cellular functions enriched in the data set included focal adhesion, adherens junction, and ErbB signaling. Five receptor tyrosine kinases (RTKs) were detected, with EGFR and EPHA2 most prevalent. Src-family kinases (YES, LYN, FRK and LCK) and focal adhesion kinase (FAK) comprised the majority of non-receptor tyrosine kinases measured. Analysis of individual pY sites on 14 tyrosine kinases indicates their activation by kinase domain activation loop phosphorylation, but also revealed additional pY sites suggestive of regulation by trafficking/endocytosis and inter- and intra-molecular protein-protein interactions involving, for example, SH2 and SH3 domains, and extra-kinase domain regions. Analysis of tumors based on protein-pY suggested subtypes distinguished by their activated tyrosine kinase networks. Genetic analysis of 3 tumors that displayed EGFR-associated phospho-proteome signatures confirmed that they carried either EGFR activating mutations (in two ADCs) or increased gene copy number (in one SCC). Western blot analysis of protein pY confirmed different patterns of cellular protein pY among the tumor phospho-types in agreement with the phospho-proteomic analysis. Quantification of kinase and substrate pY sites, according to their integrated extracted ion currents, revealed a set of phosphorylations that constituted a molecular signature that differentiated between the ADC and SCC subtypes. In summary, quantitative phospho-proteomic profiling of NSCLC tumors is feasible and may have utility in the categorization of individual tumors according to their networks of activated tyrosine kinases and substrates. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 103rd Annual Meeting of the American Association for Cancer Research; 2012 Mar 31-Apr 4; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2012;72(8 Suppl):Abstract nr 4805. doi:1538-7445.AM2012-4805