tbuckley/cabot-search huggingface dataset:
Abstract 3858: Micropatterned Ventricular Slice: Role of Realistic Tissue Microstructure in Impulse Conduction
Authors: Nima Badie, Nenad Bursac
Journal: Circulation (2008)

We developed novel cultures of neonatal rat cardiomyocytes that accurately replicate the MRI-measured microstructure of murine ventricular cross-sections. The individual roles of realistic tissue boundaries and changes in local myofiber direction in impulse conduction were studied by optically mapping membrane voltage (Fig A1 ) in (1) micropatterned cultures with realistic tissue boundaries and natural (anisotropic) cell orientation (Fig A2 ) and (2) controls with the same boundaries but random (isotropic) cell orientation (Fig A3 ). Compared to isotropic controls, anisotropic cultures exhibited a 27% larger spatial dispersion of conduction velocity (CV) at 2 Hz pacing, 17% faster rise in CV dispersion during ramp pacing (5–14 Hz), and 100% higher incidence of remote conduction block, which occurred exclusively at the junctions between the septum and right ventricle (RV) free wall due to current source-sink mismatches and sharp turns in cardiac fiber directions. The incidence of block with ramp pacing was pacing site dependent from the RV, septum, and left ventricle (LV), yielding remote blocks in 77%, 38%, and 0% of anisotropic and 33%, 25%, and 0% of isotropic cultures (Fig B ). In anisotropic cultures, the cycle length of resulting anatomical reentries (normalized by CV) was 34% shorter in LV- vs RV-driven reentry (Fig C1–2 ), due to a shorter wave path. Overall, realistic tissue boundaries and fiber directions synergistically increase the non-uniformity of conduction, render specific regions highly susceptible to conduction block, and determine reentry rate. These purely structural effects are independent of the presence of regional variations of cell ionic properties. This research has received full or partial funding support from the American Heart Association, AHA Mid-Atlantic Affiliate (Maryland, North Carolina, South Carolina, Virginia &amp; Washington, DC).
Abstract 4352: Closing the Treatment Gap in Heart Failure. Angiotensin Converting Enzyme Inhibitor Therapy in Patients with Renal Failure and Effect on Survival
Authors: Virginia B Thayer, Vicki L McHugh, Kara A Kallies, Michelle A Mathiason, John P Porcari, Kwame O Akosah
Journal: Circulation (2008)

Background: Heart failure (HF) clinical trials exclude subjects with renal failure (RF), and it is unclear if these patients can be treated as recommended by the guidelines. We sought to determine if poor outcomes is this population is due to RF or to the failure to receive recommended medications. Methods: Retrospective analysis of 500 subjects admitted to Gundersen Lutheran HF disease management clinic from 4/99 to 1/03. RF was defined as serum creatinine ≥2.0 mg/dL. Data were collected annually for seven years. Endpoints were defined as all cause hospitalization and all cause death. Results: Complete data was available on 449 subjects. Of these, 140 met criteria for RF and 309 had normal renal function. Subjects with RF were older (71±12 vs. 67±13 years, p=0.002) but had higher LVEF (26±9 vs. 23±10%, p=0.011). Subjects were followed for a median of 6.8 years. Overall, subjects with RF had worse outcomes for all cause death (p=0.001) and for all cause hospitalizations (p=0.001) compared to subjects without RF. Among subjects with RF, the success rate for treatment with ACEI/ARB was 90% (n=126). Subjects treated were classified as Group1, and those not tolerating treatment as Group 2. Death rates at one year were better among those treated (17% vs. 23 %). However, hospitalization rates at one year were similar (41% vs. 43%). KM analysis revealed significant group effect of ACEI/ARB outcomes (p=0.001). Conclusion: 90% of subjects with RF were successfully treated and treatment was associated with better survival. This suggests that benefit of ACEI/ARB does extend to those with RF, and research is needed on mechanisms to apply the guidelines to subjects with RF.
Cutaneous Blastomycosis
Authors: Alex G Ortega-Loayza, Calvin O McCall
Journal: New England Journal of Medicine (2013)

A 65-year-old man presented with a large facial plaque that was unresponsive to topical and oral antibiotics. Previous pulmonary imaging had revealed a pleural effusion and a mass in the lingula; subsequent lung biopsy was inconclusive for tuberculosis.
Abstract 1851: Safety of Aprotinin in CABG Patients: Results of the VA MultiCenter Prospective Randomized ROOBY Trial
Authors: Marco Zenati, Ali Sonel, Richard Bjerke, Laurie Shroyer, Joseph Collins
Journal: Circulation (2007)

Background and Hypothesis : Recently published evidence from an international registry ( JAMA 2007 ; 297 : 471 –479 ) associated the use of aprotinin during CABG with increased mortality (20.8%) compared with controls (12.7%) and recommended discontinuation of the clinical use of aprotinin as unsafe. Because evidence from registries is generally inferior compared to prospective multicenter randomized trials, we sought to determine if there was increased mortality with the use of aprotinin in a large, prospective randomized CABG trial in the United States. Based on a large body of available literature on the use of antifibrinolytic agents during CABG, we hypothesized that the use of aprotinin would not be associated with excessive mortality in the ROOBY Trial. Methods : The prospective randomized ROOBY Trial enrolled &gt;2,200 patients over five years at 18 VA cardiac surgery centers in the United States. A planned sub analysis was carried out on 1,750 CABG patients with one year follow up using collected data on the antifibrinolytic agent use. Results : Aprotinin was used during CABG (either on- or off-pump) by the majority of the centers participating in ROOBY (11/18=61%). One-year mortality for the aprotinin group was 3.2% and the mortality for the control group of patients receiving either no anti-bleeding agents or one of 2 lysine analog antifibrinolytics (aminocaproic acid or tranexamic acid) was 3.5% (p=.59). In addition, the rate of myocardial infarction at one year was similar in the 2 groups (aprotinin 3.2% vs 3.27% for the controls; p=NS). The rate of repeat revascularization at one year was slightly higher in the control group (4.05%) compared to the aprotinin group (2.6%). Conclusion : In the planned sub analysis of the prospective randomized ROOBY trial, no excessive mortality or morbidity was found to be associated with the use of aprotinin and the recommendation for discontinuation of clinical use of aprotinin in CABG appears unjustified. Adherence to the revised FDA indications for use of aprotinin during CABG should be emphasized.
Abstract 2981: Long Term (3 Years) Outcome in Patients with Unprotected Left Main Coronary Artery Stenosis Treated with Drug-Eluting Stent Implantation
Authors: Alaide Chieffo, Renata Rogacka, Valeria Magni, Flavio Airoldi, John Cosgrave, Massimo Ferraro, Matteo Montorfano, Iassen Michev, Enrico Romagnoli, Cosmo Godino, Antonio Colombo
Journal: Circulation (2007)

Background: The long-term safety and efficacy of drug-eluting stent (DES) implantation in the treatment of unprotected left main coronary artery (LMCA) stenosis is still a matter of debate. Some concerns have been recently raised regarding the risk of late stent thrombosis Methods: All consecutive patients (pts) who had sirolimus (SES, Cypher, Cordis, Johnson and Johnson Company, Warren, NJ) or paclitaxel-eluting stent (PES, Taxus, Boston Scientific, Natick, MA) electively implanted in de novo lesions on LMCA between March 2002 and June 2004 were analyzed. Results: A total of 107 pts were treated: 52 with PES and 55 with SES. Twenty (18.3%) patients were diabetics, 34 (31.8%) unstable angina, mean age 63.8±10.3 years, EF 52.0±10.4. High mortality risk scores (Euroscore &gt;6) were present in 34 (31.7%) of the patients. Eighty-seven (81.3%) patients had distal left main lesions: 77 bifurcations and 10 trifurcations. Both branches were stented in 64 (73.6%) pts: crush technique was performed in 38 (59.4%) of them. Reference vessel diameter was 3.3±0.68mm. Procedural success was achieved in all pts. During hospitalization 10 (9.3%) patients had CK-MB elevation ≥ 5 ULN. None of the patient had Q wave myocardial infarction (MI), died or had CABG. At 1206±347 days clinical follow-up, 11 (10%) patients died, 8 (7.4%) of them were adjudicated as cardiac deaths according to ARC definition. Five of the cardiac deaths could be considered as possible late stent thrombosis. Only 1 had a definite late stent thrombosis (in the left anterior descending artery with MI treated with re-PCI at 3 months while on dual antiplatelet therapy). TVR (defined as any revascularization in left coronary system) occurred in 26 (24.2%) patients and 19 (17%) TLR (defined as any revascularization in the stented segment): 21 had a re-PCI and 5 CABG. Angiographic follow-up performed in 94 (87.8%) pts showed restenosis in 16 pts (17%); all restenosis occurred in pts with treatment of distal left main and were focal. Conclusions Treatment of LMCA stenosis with DES appears safe with favorable and improved clinical results maintained at long term clinical follow-up..
タンパク質チロシンキナーゼ(c‐Src)によるヒト遅延整流カリウムイオンチャネル遺伝子(HERG)チャネル輸送の転形
Authors: WU Lm, Ueda K, Yamanashi Y, Yasunami M, Kimura A, Aizawa Y, Furukawa T, Hiraoka M
Journal: Circulation (2005)
Biologic response to anti-CD16 monoclonal antibody therapy in a human immunodeficiency virus-related immune thrombocytopenic purpura patient
Authors: C Soubrane, JM Tourani, JM Andrieu, S Visonneau, K Beldjord, D Israel-Biet, R Mouawad, J Bussel, M Weil, D Khayat
Journal: Blood (1993)
Liver free papers 108-123
Authors: G. Constable, D. Cumming, P.J. Wood, S. Wootton, Stroud
Journal: Gut (2002)

Introduction: Previous studies, many uncontrolled, suggest 4 to 32% of people develop irritable bowel syndrome (IBS) after ID.Little information is available on the development of other FGIDs after ID.Aim: To determine if patients with stool culture confirmed bacterial diarrhoea were more likely to develop gut symptoms consistent with a diagnosis of IBS, functional dyspepsia or functional diarrhoea at 3 and 6 month follow up compared with community controls.Methods: A prospective community-based case-control study over one year.Subjects with stool positive bacterial infectious diarrhoea and control subjects from the same primary care practice were invited to participate.The presence or not of IBS, functional dyspepsia or functional diarrhoea was diagnosed at the start and at follow up using self-complete Rome II modular questionnaires.The diagnosis of a baseline FGID excluded subjects from continuing.There were 128 cases and 219 community controls eligible and who consented to participate.Results: At follow up there was a higher incidence of FGIDs in the cases compared with controls, mainly due to a higher incidence of IBS (see table ).There was no difference in the incidence of functional dyspepsia between cases and controls.Conclusions: IBS and functional diarrhoea is diagnosed more frequently in people at three and six-month follow up after an episode of stool positive bacterial diarrhoea compared with community controls despite careful exclusion of people with pre-existing FGIDS and adds further support for the concept of post-infectious IBS.
Evaluation of Global and Regional Left Ventricular Function With 16-Slice Computed Tomography, Biplane Cineventriculography, and Two-Dimensional Transthoracic Echocardiography
Authors: Marc Dewey, Mira Müller, Stephan Eddicks, Dirk Schnapauff, Florian Teige, Wolfgang Rutsch, Adrian C. Borges, Bernd Hamm
Journal: Journal of the American College of Cardiology (2006)
Abstract 2876: Risk of Thromboembolic Events After Percutaneous Left Atrial Radiofrequency Ablation of Atrial Fibrillation
Authors: Hakan Oral, Aman Chugh, Mehmet Ozaydin, Eric Good, Jackie Fortino, Sundar Sankaran, Stephen Reich, David Tschopp, Darryl Elmouchi, Alan Wimmer, Sujoya Dey, Thomas Crawford, Frank Pelosi, Krit Jongnarangsin, Frank Bogun, Fred Morady
Journal: Circulation (2006)
Immunolocalization of the ICE/Ced-3–Family Protease, CPP32 (Caspase-3), in Non-Hodgkin's Lymphomas, Chronic Lymphocytic Leukemias, and Reactive Lymph Nodes
Authors: Stanislaw Krajewski, Randy D. Gascoyne, Juan M. Zapata, Maryla Krajewska, Shinichi Kitada, Mukesh Chhanabhai, Douglas Horsman, Ken Berean, Lawrence D. Piro, Isabelle Fugier-Vivier, Yong-Jun Liu, Hong-Gang Wang, John C. Reed
Journal: Blood (1997)
Abstract 15608: Impaired Myocardial Perfusion Reserve in Patients with Fatty Liver Disease Assessed by Quantitative Myocardial Perfusion MRI
Authors: Shiro Nakamori, Katsuya Onishi, Hiroshi Nakajima, Shingo Kato, Yeonyee E Yoon, Kakuya Kitagawa, Kaoru Dohi, Mashio Nakamura, Hajime Sakuma, Masaaki Ito
Journal: Circulation (2010)

Background: Nonalcoholic fatty liver disease has been shown to be a risk factor of coronary artery disease (CAD) even in patients without metabolic syndrome. However, the relationship between fatty liver and altered myocardial perfusion reserve (MPR) has not been investigated in subjects without CAD. The purpose of this study was to determine whether the presence of fatty liver is associated with subclinical alteration of MPR in subjects without CAD. Methods: A retrospective analysis was performed on 65 asymptomatic subjects without CAD who underwent both plain abdominal CT and cardiac MRI, and who also demonstrated normal LV wall motion, no regional myocardial ischemia and no myocardial scar on MRI. Myocardial perfusion MRI was acquired with a dual bolus method for saturation correction. Myocardial blood flow (MBF) was quantified in 16 myocardial segments by using a Patlak plot method. MPR was calculated as stress MBF divided by rest MBF. Results: Fatty liver was observed in 18 (28%) of 65 subjects. No s...
Abstract 3194: Clinical Characteristics And Physical Activity Patterns Among The Least-fit And The Next-least-fit Quintile Of Individuals With Cardiovascular Disease
Authors: Sandra Mandic, Jonathan Myers, Ricardo B Oliveira, Joshua P Abella, Victor F Froelicher
Journal: Circulation (2008)

A graded non-linear relationship exists between fitness and all-cause mortality with the most remarkable difference in mortality rates observed between the least-fit (first, Q1) and the next-least-fit (second, Q2) quintile of fitness. The purpose of this study was to compare clinical characteristics, exercise test responses and physical activity patterns in Q1 versus Q2 in individuals with cardiovascular disease (CVD). A total of 5101 consecutive patients referred for clinical exercise testing from 1987 to 2006 were followed for a mean (±SD) of 9.1±5.5 years. All subjects had a history of CVD and/or abnormal exercise test results. Subjects were classified into quintiles of exercise capacity measured in metabolic equivalents (METs) and the first 2 quintiles were compared (Q1: METs &lt;4.2 (n=923); Q2: METs 4.3–5.9 (n=929)). In a subset (n=655), recreational physical activity was assessed using a questionnaire. Q1 had an almost 2-fold increase in age-adjusted relative risk of mortality compared to Q2 (cardiovascular mortality: HR (95% CI): 3.79 (1.73, 8.29) vs. 2.04 (1.9, 4.6), p&lt;0.05; reference group: fittest subjects (Q5, METs &gt;10.0)). Q1 were older (67±9 vs. 64±10 years, p&lt;0.001), had more extensive use of medications and were more likely to have a history of typical angina (35% vs. 28%, p&lt;0.004), myocardial infarction (30% vs. 24%, p=0.003), chronic heart failure (25% vs. 14%, p&lt;0.001), claudication (15% vs. 9%, p&lt;0.001) and stroke (9% vs. 6%, p=0.027) compared to Q2. Prevalence of dyslipidemia, current smoking rates, treatment with ACE-inhibitors, statins and diuretics, and exercise test responses were lower in Q1 versus Q2. Recent (1263±1783 kcal/week vs. 1566±2161 kcal/week, p=0.22) and lifetime (1323±1847 kcal/week vs. 1619±1830 kcal/week, p=0.23) recreational physical activity were not different between the groups. Marked differences in mortality rates between the least-fit and the next-least-fit quintiles appear to be due to a greater severity of disease and comorbidities rather than differences in physical activity patterns. These findings suggest that higher levels of fitness are required to improve survival in individuals with CVD.
Ganglionated Plexi Modulate Extrinsic Cardiac Autonomic Nerve Input
Authors: Yinglong Hou, Benjamin J. Scherlag, Jiaxiong Lin, Ying Zhang, Zhibing Lu, Kim Truong, Eugene Patterson, Ralph Lazzara, Warren M. Jackman, Sunny S. Po
Journal: Journal of the American College of Cardiology (2007)
Abstract 17515: Comparison Of Neointimal Coverage between Resolute Zotarolimus-eluting Stent and Sirolimus-eluting Stent using Optical Coherence Tomography
Authors: Jin-sun Kim, Jung-Sun Kim, Young-Guk Ko, Donghoon Choi, Yangsoo Jang, Namsik Chung, Won-Heum Shim
Journal: Circulation (2010)

Background: Resolute Zotarolimus-eluting stent (ZES-R) has extended drug elution period comparing to the existing ZES, thereby trying to suppress delayed arterial healing in more complex lesions an...
Abstract 15098: Extracorporeal Membrane Oxygenation as a Bridge to Life for Refractory Cardiogenic Shock
Authors: Vincenzo Tarzia, Nicola Gasparetto, Luisa Cacciavillani, Tomaso Bottio, Roberto Bianco, Martina Perazzolo Marra, Ervis Hiso, Armando Marzari, Sabino Iliceto, Gino Gerosa
Journal: Circulation (2011)

Objectives Cardiogenic shock refractory to conventional therapy has very high mortality and limited therapeutical options. Aim of the study was to evaluate the impact of the use of ECMO as a life-s...
Abstract 722: Noninvasive Assessment of Carotid Arterial Mechanics in Marfan Syndrome Using Velocity Vector Imaging
Authors: Wooin Yang, Chi-Young Shim, In-Jeong Cho, Sung-Ae Kim, Hyuk-Jae Chang, Yangsoo Jang, Namsik Chung, Jong-Won Ha
Journal: Circulation (2009)
Myelodysplastic Syndromes Clinical Practice Guidelines in Oncology
Authors: Peter L. Greenberg, Maria R. Baer, John M. Bennett, Clara D. Bloomfield, Carlos M. De Castro, H. Joachim Deeg, Marcel P. Devetten, Peter D. Emanuel, Harry P. Erba, Eli Estey, James Foran, Steven D. Gore, Michael Millenson, Willlis H. Navarro, Stephen D. Nimer, Margaret R. O'Donnell, Hussain I. Saba, Kathy Spiers, Richard M. Stone, Martin S. Tallman
Journal: Journal of the National Comprehensive Cancer Network (2006)

The myelodysplastic syndromes (MDS) represent myeloid clonal hemopathies with relatively heterogeneous spectrums of presentation. The major clinical problems in these disorders are morbidities caused by patients' cytopenias and the potential for MDS to evolve into acute myeloid leukemia (AML). Managing MDS is complicated by the generally advanced age of the patients (median ages range from 65–70 years), the attendant non-hematologic comorbidities, and older patients' relative inability to tolerate certain intensive forms of therapy. In addition, when the illness progresses into AML, these patients experience lower response rates to standard therapy than patients with de novo AML. For the most recent version of the guidelines, please visit NCCN.org
Abstract 2832: Which Cardiac Marker is Most Useful to Predict Final Infarct Size and Cardiac Function Following Primary Percutaneous Coronary Intervention For Acute Myocardial Infarction?
Authors: Stanley Chia, O. Christopher Raffel, Faisal Merchant, Frans J Wackers, Fred Senatore, Ik-Kyung Jang
Journal: Circulation (2007)

Background: Assessment of cardiac biomarker release has been traditionally used to estimate the size of myocardial damage after acute myocardial infarction (AMI). However, the significance of cardiac biomarkers in the setting of primary percutaneous coronary intervention (PCI) has not been systematically studied in a large patient cohort. We evaluated the usefulness of serial and single time-point measures of various cardiac biomarkers (creatine kinase (CK), CK-MB, troponin T and I) in predicting infarct size and left ventricular ejection fraction (LVEF) after primary PCI. Methods: EVOLVE (Evaluation of MCC-135 for Left Ventricular Salvage in AMI) was a randomized double-blind, placebo-controlled trial comparing the efficacy of intracellular calcium modulator as an adjunct to primary PCI in patients with first large AMI. Levels of cardiac biomarkers (CK, CK-MB mass, troponin T and I) were determined in 375 patients at baseline before PCI and 2, 4, 12, 24, 48 and 72 hours thereafter. Single photon emission computed tomography imaging was performed to measure infarct size and LVEF on day 5. Results: Area under curve and peak concentrations of all cardiac markers: CK, CK-MB mass, troponin T and troponin I were significantly correlated with myocardial infarct size and LVEF determined on day 5 (Spearman correlation, all P&lt; 0.001; Table ). Troponin I, however provided the best predictor and a single measure at 72 hr was a strong indicator of both infarct size and LVEF. Using receiver operator characteristics curve, troponin I cutoff value of &gt;55 pg/mL at 72 hr has 90% sensitivity and 70% specificity for detection of large infarct size≥10% ( c =0.88; P&lt; 0.001). Conclusions: Plasma levels of CK, CK-MB, troponin T and troponin I remain useful predictors of infarct size and cardiac function in the era of primary PCI for AMI. A single measurement of circulating troponin I at 72 hours can provide an effective and convenient indicator of infarct size and LVEF in clinical practice. Correlation of cardiac biomarkers with Day 5 SPECT determined infarct size and LVEF
Amended card is used in Oxford
Authors: J. Reynolds, T. Jones, J. Madden, S. Schofield
Journal: BMJ (1996)

whether these compounds accumulate during low or high ozone episodes and, if they do, whether they are of clinical relevance.Jon G Ayres is concerned that there was in- sufficient adjustment for other confounding meteorological factors and critically black smoke or particulate matter.In fact, relative humidity, wind speed, barometric pressure, and sunshine hours were examined in the statistical models, but for reasons of editorial brevity these data were not included in the paper.The effect of ozone was not appreciably altered.
Binge Eating, Mood, and Quality of Life in Youth With Type 2 Diabetes
Authors: Wilfley D, Berkowitz R, Goebel-Fabbri A, Hirst K, Ievers-Landis C, Lipman Th, Marcus M, Ng D, Pham T, Saletsky R, Schanuel J, Van Buren D
Journal: Diabetes Care (2011)

OBJECTIVE The current study examines the prevalence of binge eating and its association with adiposity and psychosocial functioning in a large, diverse sample of youth with type 2 diabetes. RESEARCH DESIGN AND METHODS In the TODAY study, 678 (mean age 14.0 years; 64.9% girls) of the 704 youth randomized to the study completed a self-report measure of eating disorder symptoms and were categorized as nonovereaters, overeaters, subclinical binge eaters, or clinical binge eaters. RESULTS Youth with clinical (6%) and subclinical (20%) levels of binge eating had significantly higher levels and rates of extreme obesity, global eating disorder and depressive symptoms, and impaired quality of life. CONCLUSIONS These findings highlight the importance of evaluating youth with type 2 diabetes for the presence of binge eating. Future research is needed to determine the cumulative effects of disordered eating, obesity, and psychosocial distress on adherence to lifestyle change recommendations and longitudinal response to treatment.
Abstract 2391: Trends In Early And 6-month Mortality Over 10 Years In Diabetic Vs Non Diabetic Patients With Acute Myocardial Infarction. Results From The USIK 1995, USIC 2000 And FAST-MI French Registries
Authors: Nicolas Danchin, Yves Cottin, Marianne Zeller, P Gabriel, Jacques Machecourt, Pascal Gueret, Claude Barnay, Tabassome Simon, Jean-Pierre Cambou
Journal: Circulation (2007)