ACUTE DISSEMINATED PULMONARY HISTOPLASMOSIS TREATED WITH CORTISONE AND MRD-112
Authors: A S TEGERIS, D T SMITH
Journal: Annals of Internal Medicine (1958)

Case Reports1 June 1958ACUTE DISSEMINATED PULMONARY HISTOPLASMOSIS TREATED WITH CORTISONE AND MRD-112ANDREW S. TEGERIS, DAVID T. SMITH, F.A.C.P.ANDREW S. TEGERISSearch for more papers by this author, DAVID T. SMITH, F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-48-6-1414 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptEpidemics of acute pulmonary histoplasmosis have been recognized with increased frequency in recent years. In 1957 Lehan and Furcolow collected 38 epidemics involving over 400 individuals.1 Although many of the patients were seriously ill for weeks, there were only five deaths, and three of these were in children. The low mortality (1.2%) suggests that most patients develop adequate immunity.2 They also develop an allergy of the tuberculin type to histoplasmin within the first two to three weeks of the disease.In the case to be reported the patient was exposed to bat manure in a cave and apparently received a...Bibliography1. LehanFurcolow PHML: Epidemic histoplasmosis, J. Chron. Dis. 5: 489, 1957. CrossrefMedlineGoogle Scholar2. ParrottTaylorPostonSmith TGMADT: An epidemic of histoplasmosis in Warrenton, North Carolina, South. M. J. 48: 1147, 1955. CrossrefMedlineGoogle Scholar3. Fox H: Exfoliative dermatitis complicated by fatal acute disseminated histoplasmosis, Arch. Dermat. and Syph. 68: 734, 1953. Google Scholar4. Shull HJ: Human histoplasmosis: a disease with protean manifestations, often with digestive system involvement, Gastroenterology 25: 582, 1953. CrossrefMedlineGoogle Scholar5. SilvermanSchwarzLaheyCarson FNJMERP: Histoplasmosis (review), Am. J. Med. 19: 410, 1955. CrossrefMedlineGoogle Scholar6. EllisCallander MRJ: Treatment of histoplasmosis with MRD-112. Report of a case, J. Tennessee M. A. 48: 411, 1955. Google Scholar7. Sutliff WD: Experience with the course and chemotherapy of chronic pulmonary histoplasmosis, Am. Rev. Tuberc. 75: 912, 1957. MedlineGoogle Scholar8. FarrellColePriorSaslaw RLCRJAS: Experimental histoplasmosis. I. Methods for production of histoplasmosis in dogs, Proc. Soc. Exper. Biol. and Med. 84: 51, 1953. CrossrefMedlineGoogle Scholar9. MankowskiLittleton ZTBJ: Action of cortisone and ACTH on experimental fungus infections, Antibiotics and Chemotherapy 4: 253, 1954. Google Scholar10. BaumAdrianoSchwarz GLSJ: The effect of cortisone on experimental histoplasmosis in mice, Am. J. Clin. Path. 24: 903, 1954. CrossrefMedlineGoogle Scholar11. VogelMichaelTimpe RAMA: Cortisone in experimental histoplasmosis, Am. J. Path. 31: 535, 1955. MedlineGoogle Scholar12. IsraelDeLamaterSonesWillisMirmelstein HLEMWDA: Case report: chronic disseminated histoplasmosis; an investigation of its relationship to sarcoidosis, Am. J. Med. 12: 252, 1952. CrossrefMedlineGoogle Scholar13. SalvinFurcolow SBML: Precipitins in human histoplasmosis, J. Lab. and Clin. Med. 43: 259, 1954. MedlineGoogle Scholar14. LudwigMurraySmithThompsonWerner KAFJJKCRHW: Laboratory studies on beta-di-ethylaminoethyl fencholate, a new antifungal agent, Antibiotics and Chemotherapy 4: 56, 1954. Google Scholar15. PolkBrasherDeCastroBuckingham JWCAJWW: The surgical treatment of pulmonary histoplasmosis with an evaluation of MRD-112 as a possible adjunct, J. Thoracic Surg. 31: 148, 1956. CrossrefGoogle Scholar16. LehanFurcolowBrasherLarsh PHMLCEHW: Therapeutic trials with the newer antifungal agents, Antibiotics Annual, 1956-1957, Medical Encyclopedia, Inc., New York, pp. 467-469. Google Scholar17. MichaelVogel MRA: Histoplasmosis: report of a case, with observations on management, New England J. Med. 251: 884, 1954. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: *Received for publication August 28, 1957.From the Departments of Medicine and Microbiology, Duke University School of Medicine, Durham, North Carolina.Requests for reprints should be addressed to David T. Smith, M.D., Department of Bacteriology, Duke University School of Medicine, Durham, North Carolina. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byHISTOPLASMOSISHistoplasma capsulatumDiagnosis and management of HistoplasmosisHistoplasmosisAn outbreak and review of cave-associated histoplasmosis capsulatiBiological Activity of the Terpenoids and Their DerivativesThe Use of Adrenocorticotropin and the Corticosteroids in Thoracic DiseaseMycotic Diseases of the Lung 1 June 1958Volume 48, Issue 6Page: 1414-1420KeywordsAllergic diseasesAllergy and immunologyBatsChildrenDyspneaHistoplasma capsulatumHistoplasmosisMicrobiologyMortalityTuberculin ePublished: 1 December 2008 Issue Published: 1 June 1958 PDF downloadLoading ...