tbuckley/cabot-search huggingface dataset:
Abstract 1248: Intralesional injection with PV-10 induces a systemic anti-tumor immune response in murine models of breast cancer and melanoma.
Authors: Shari A. Pilon-Thomas, Amy Weber, Krithika Kodumudi, Lisa Kuhn, Paul Toomey, Amod Sarnaik
Journal: Cancer Research (2013)

Abstract PV-10 is a 10% solution of Rose Bengal that is currently being examined as a novel cancer therapeutic. In melanoma patients, intralesional injection (IL) of PV-10 has led to regression of injected lesions as well as distant metastases. In this study, we examined the efficacy and potential immune mechanism of PV-10 treatment in murine models of breast cancer and melanoma. In BALB/c mice bearing MT-901 breast cancer, injection of PV-10 led to regression of injected and untreated contralateral subcutaneous lesions (p&amp;lt;0.05 compared to IL-PBS-treated mice). A significant increase in survival was observed in mice treated with PV-10. To examine immune response, MT901-specific IFN-gamma production and cytotoxicity were measured in splenocytes collected from mice treated with IL-PBS or IL-PV-10. MT901-bearing mice treated with IL-PV-10 demonstrated enhanced IFN-gamma production (992 ± 453 pg/ml) compared to splenocytes from PBS-treated mice (174 ± 105, p&amp;lt;0.05). In addition, a significant increase in lysis of MT-901 cells by T cells after PV-10 treatment was observed (p&amp;lt;0.01 compared to PBS-treated mice). No lysis of irrelevant CT-26 cells was detected. In a murine model of melanoma, B16-F10 cells were injected into C57BL/6 mice to establish one subcutaneous tumor and multiple lung lesions. Treatment of the subcutaneous lesion with a single injection of IL-PV-10 led to regression of the injected lesion as well as distant B16 melanoma lung metastases. In B16-bearing mice, treatment with IL-PV-10 led to the induction of T cells that produced IFN-gamma in response to B16 tumors but not irrelevant tumor (p&amp;lt;0.05) and demonstrated specific lysis of B16 (p&amp;lt;0.01 compared to T cells isolated from PBS-treated mice). In total, these studies support the induction of tumor-specific T cell-mediated immunity after single treatment with IL-PV-10 in multiple histologic subtypes. The immune mechanism of PV-10 ablation in cutaneous melanoma patients is currently under investigation at our institution. Citation Format: Shari A. Pilon-Thomas, Amy Weber, Krithika Kodumudi, Lisa Kuhn, Paul Toomey, Amod Sarnaik. Intralesional injection with PV-10 induces a systemic anti-tumor immune response in murine models of breast cancer and melanoma. [abstract]. In: Proceedings of the 104th Annual Meeting of the American Association for Cancer Research; 2013 Apr 6-10; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2013;73(8 Suppl):Abstract nr 1248. doi:10.1158/1538-7445.AM2013-1248
P329GATA5: a key player in congenital heart diseases
Authors: K Kassab, H Hariri, A Fahed, I El-Rassi, F Bitar, G Nemer
Journal: Cardiovascular Research (2014)

Purpose: The role of GATA5 in the morphogenesis of aortic valve has been recently elucidated in the mice knock out model. Growing evidence demonstrates that genetic defects in GATA5 might be responsible for various forms of congenital heart diseases (CHDs) in humans. The published results however were neither supported by functional data, nor by proper genetic controls. The aim of this proposal is to unravel the role of GATA5 in such diseases, and establish a well-defined genotype/phenotype association. Methods: Blood was collected from children with CHD. Sanger sequencing was carried out on all coding exons of GATA5. Site directed mutagenesis was carried out on the corresponding human GATA5 cDNA and the generated expression vector was tested in transfected cells. Results: One novel mutation (T67P) and another previously reported mutation (Y142H) have been identified in four out of 150 patients screened. Unlike all previously described mutations in GATA5, our mutations were homozygous. The T67P mutation in one patient is homozygous as a consequence of one inherited allele and another de novo mutated allele. The Y142H mutation is in the trans-activating domain of the GATA5 protein suggesting a direct effect on the transcriptional properties of the protein. In vitro assays, did show a consistent reproducible 30-40% drop in transcativtional activities over the corresponding GATA binding sites on different promoters.
Home or hospital?
Authors: S Barley
Journal: BMJ (1978)

parents who didn't take advantage of early antenatal care, but the problem is different with adults and smoking.Dr GODBER: The incentives will always have to be positive rather than punitive.Mr LAING: I wonder.I agree that financial incentives are rather blunt, but what other ways can one think of to make people better citizens, which is what it amounts to ?Professor RAWLINS: Is there good evidence that health education will change people's established ways of life ?Dr ROSENTHAL: It depends what you call health education.The bikini and blue jeans did more to reduce adolescent obesity than any prohibition against bad nutrition.Dr WILL: Fashion has been very much neglected, hasn't it, though it is very difficult to influence ?The problem about selling a good message is that it is somehow very self-conscious in a way that immediately switches people off.
Cost utility analysis on one-step nucleic acid amplification method for the detection of axillary metastasis in breast cancer.
Authors: K Nishimura, D Sugiyama, A Moronobu, S Kawano, S Kumagai
Journal: Cancer Research (2009)

Abstract Abstract #1014 Back ground :OSNA method, One-step Nucleic Acid Amplification(OSNA) method is a new method for rapid detection of axillary lymph node metastases of breast cancer using PCR to detect cytokeratin 19's mRNA and different from conventional hsitopathological examination. It can be automated and can detect the axillary lymph node metastases quickly and precisely during operation. No cost effectiveness studies are conducted for this method.&amp;#x2028; Materials and Method: We conducted the cost effectiveness analysis for this method comparing with conventional hsitopathological method using Markov models. We adopted the societal perspectives and the time horizon for fives years. We used TreeAge Pro 2005 (TreeAge Software Inc, Williamsontown, MA) to conduct Markov simulations. One way sensitivities analysis were conducted for all parameters. Cost and utilities data were collected from the studies and clinical trials for OSNA and conventional methods.&amp;#x2028; Results: When the cost of OSNA is assumed as the same as intra-operative lymph node diagnosis by histopathology, the Markov model has shown the cost saving of $11,527/QALY by OSNA method. When the sensitivity analysis was performed by changing the cost of OSNA, the result has shown that OSNA can still show cost saving until the cost of OSNA method is $1,094 higher than the hsitopathological examination. Discussion: Our results clearly revealed OSNA methods is cost saving compared with convention intraoperative hsitopathological examinations. Result is robust for all parameters included in the model. Since OSNA method can avoid unnecessary re operations for axillary lymphadenectomy, this method can improve the quality of life for breast cancer patients. Citation Information: Cancer Res 2009;69(2 Suppl):Abstract nr 1014.
Chronic Fatigue Syndrome
Authors: Benjamin H. Natelson
Journal: JAMA (2001)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Book Review Treating and Preventing Adolescent Mental Health Disorders: What We Know and What We Don't Know: A Research Agenda for Improving the Mental Health of Our Youth Edited by Dwight L. Evans, Edna B. Foa, Raquel E. Gur, Herbert Hendin, Charles P. O'Brien, Martin E.P. Seligman, and B. Timothy Walsh. 818 pp. New York, Oxford University Press, 2005. $59.50. 0-19-517364-3
Authors: Harsh K. Trivedi
Journal: New England Journal of Medicine (2006)
Francis Tasker Wheeldon
Authors: P T Wheeldon
Journal: BMJ (2005)

Medical microbiologist who became a pioneer of hospital infection controlRobert Blowers had a lifelong interest in Staphylococcus aureus and hospital infection.From the mid-1950s onwards he produced a succession of publications on the prevention of hospital infections, particularly those following surgery.These ranged across the design of operating theatres, isolation rooms, and surgical clothing, and the prevention of the airborne spread of infection and clinical protocols for wound management.He co-produced the seminal textbook Hospital Infection: Causes and Prevention, which became the "bible" on infection control for nearly 20 years.In 1959 he was a key member of the Ministry of Health working group that produced a report on staphylococcal infections in hospitals.At a Department of Health workshop in December 2004, just a week before Robert's death, his major contribution was recalled by the department's inspector of microbiology and infection control, who had that week sent him a Christmas card with the message "you will be pleased to know that we are at last trying to implement your 1959 recommendations!"
Weight Gain After Cessation of Smoking
Authors: Jetson E. Lincoln
Journal: JAMA (1969)

<h3>To the Editor:—</h3> Further to Dr. Glauser's report of weight gain after cessation of smoking (<b>209</b>:1621, 1969), we have accumulated data indicating that male cigarette smokers consume about 350 calories a day more than nonsmokers. For heavy smokers, the excess daily calorie consumption appears to be about 575 calories. Notwithstanding their calorie consumption, adult smokers weigh about 2.9 kg (6.5 lb) less than the nonsmokers (age, height, and income being matched), and with no material differences in physical energy expenditure. Among former cigarette smokers, the percentage of those who are "making an effort to keep their weight down" is 53%, compared with 32% for current cigarette smokers, and 27% for current heavy cigarette smokers. With regard to daily calorie intake and weight, former smokers, in the aggregate, are quite similar to those who have never smoked. Data for the behavior of recent abstainers are based on rather small numbers,
Treatment of Human Immunodeficiency Virus in Adults
Authors: Tom A. Yates, Joseph Sonnabend
Journal: JAMA (2012)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Release of Adenosine from Anoxic Hearts
Authors: MAKOTO KATORI, ROBERT M. BERNE
Journal: Circulation Research (1966)

In the presence of 8-azaguanine, an inhibitor of adenosine deaminase, adenosine appears in the perfusate of isolated cat and guinea pig hearts subjected to anoxia or severe hypoxia. With graded hypoxia the increase in coronary flow is roughly proportional to the sum of adenosine, inosine and hypoxanthine released from the hearts and inversely related to the oxygen tension of the perfusion fluid. Addition of epinephrine to oxygenated perfusion medium yields results similar to those obtained with hypoxia. These findings are compatible with the concept that vasodilation observed with hypoxia is due to adenosine formed from the breakdown of myocardial adenine nucleotides.
Prediction of Pulmonary Embolism in the Emergency Department: The Revised Geneva Score
Authors: Grégoire Le Gal, Marc Righini, Pierre-Marie Roy, Olivier Sanchez, Drahomir Aujesky, Henri Bounameaux, Arnaud Perrier
Journal: Annals of Internal Medicine (2006)

Background: Diagnosis of pulmonary embolism requires clinical probability assessment. Implicit assessment is accurate but is not standardized, and current prediction rules have shortcomings. Objective: To construct a simple score based entirely on clinical variables and independent from physicians' implicit judgment. Design: Derivation and external validation of the score in 2 independent management studies on pulmonary embolism diagnosis. Setting: Emergency departments of 3 university hospitals in Europe. Patients: Consecutive patients admitted for clinically suspected pulmonary embolism. Measurements: Collected data included demographic characteristics, risk factors, and clinical signs and symptoms suggestive of venous thromboembolism. The variables statistically significantly associated with pulmonary embolism in univariate analysis were included in a multivariate logistic regression model. Points were assigned according to the regression coefficients. The score was then externally validated in an independent cohort. Results: The score comprised 8 variables (points): age older than 65 years (1 point), previous deep venous thrombosis or pulmonary embolism (3 points), surgery or fracture within 1 month (2 points), active malignant condition (2 points), unilateral lower limb pain (3 points), hemoptysis (2 points), heart rate of 75 to 94 beats/min (3 points) or 95 beats/min or more (5 points), and pain on lower-limb deep venous palpation and unilateral edema (4 points). In the validation set, the prevalence of pulmonary embolism was 8% in the low-probability category (0 to 3 points), 28% in the intermediate-probability category (4 to 10 points), and 74% in the high-probability category (≥11 points). Limitations: Interobserver agreement for the score items was not studied. Conclusions: The proposed score is entirely standardized and is based on clinical variables. It has sustained internal and external validation and should now be tested for clinical usefulness in an outcome study.
Joint Complaints in Polycythaemia Vera
Authors: A. M. Denman, L. Szur, B. M. Ansell
Journal: Annals of the Rheumatic Diseases (1964)

Non-melanoma skin cancer (NMSC), including both squamous cell carcinoma (SCC) and basal cell carcinoma (BCC), is a commonly diagnosed cancer in Australia. The role of the immune system in the development of NMSC is still poorly understood. Using a mouse model of precancerous, hyperplastic skin, we have investigated the expression and targeting of the T cell co-stimulatory molecule, 4-1BB (CD137). Our data shows that 4-1BB is expressed on both CD8 and non-CD8 T cells isolated from precancerous mouse skin with limited expression on T cells in normal skin or skin-draining lymph nodes. In contrast, the ligand for 4-1BB, 4-1BBL, was poorly expressed in skin and draining lymph nodes from precancerous or normal skin. Intradermal injection of antibodies against 4-1BB was more effective at labelling target cells within the hyperplastic skin than intravenous injection. Agonist antibodies against 4-1BB showed some enhancement of skin T cell function in vitro. The data suggests that 4-1BB expression is upregulated on T cells within precancerous mouse skin and may represent a promising target for immunotherapy against precancerous skin lesions.
Problems in assessing contents of metered dose inhalers.
Authors: D J Williams, A C Williams, D G Kruchek
Journal: BMJ (1993)

Clinical implications* Chronic constipation is common in elderly people in long stay hospital and nursing home care and regular laxative treatment is often required * There are few comparative clinical studies of commonly used laxatives * In this study a senna-fibre combination was more effective than lactulose in long stay elderly patients with constipation * Both treatments were well tolerated * The superior efficacy of the senna-fibre combination, without increase in side effects, resulted in considerable cost benefit compared with lactulose.
The role of biomarkers in reproductive and developmental toxicology.
Authors: T W Clarkson
Journal: Environmental Health Perspectives (1987)

A massive outbreak of methylmercury poisoning took place in the winter of 1971-1972 due to the consumption of homemade bread contaminated with a methylmercury fungicide. The longitudinal analysis of the mother's head hair, collected after delivery of the baby, provided a means of recapitulating exposure to methylmercury during pregnancy. Methylmercury is incorporated into newly formed hair at a concentration that is proportional to the simultaneous concentration in blood. Since hair grows at a rate of approximately 1 cm/month, longitudinal analysis of the hair strand, centimeter by centimeter, will give a month by month recapitulation of blood levels. Depending on the length of the hair strand, it is possible to recapitulate several years of exposure. Using longitudinal hair analysis, it was possible to compare the methylmercury levels in the mother during pregnancy with the severity and frequency of effects in her offspring. As in the previous incidents, high levels of prenatal exposure led to severe brain damage. However, it was also possible to identify milder effects of methylmercury as manifested by delayed development. It was possible to demonstrate a dose-effect and dose-response relationship between the maximum concentration of methylmercury in maternal hair during pregnancy and evidence of delayed development and mild neurological abnormalities in the offspring. These relationships provided quantitative evidence that the developing nervous system is more susceptible to damage than the mature brain.
Relevance of matrix metalloproteinases and their inhibitors after myocardial infarction: A temporal and spatial window
Authors: D VANHOUTTE, M SCHELLINGS, Y PINTO, S HEYMANS
Journal: Cardiovascular Research (2005)

The post-myocardial infarction wound repair process involves temporarily overlapping phases that include inflammation, formation of granulation tissue, scar formation, and overall left ventricle (LV) remodelling. The myocardial extracellular matrix (ECM) plays an important role in maintaining the structural and functional integrity of the heart and is centrally involved in wound repair post-myocardial infarction (MI). The main proteolytic system involved in the degradation of the ECM in the heart is the matrix metalloproteinase (MMPs) system. The present review will focus on the importance of the unique temporal and spatial window of MMPs and their inhibitors (TIMPs) within the different wound healing phases post-MI. It summarizes (1) the MMP/TIMP levels at different time points post-MI, (2) the alterations seen in post-MI healing in genetically modified mice, and (3) the effects and limitations of therapeutic MMP-inhibition post-MI.
Tenosynovitis of the Tendo Achillis
Authors: A. A. Williams
Journal: BMJ (1941)

wounds discharging Strep.pyogenies comprised those which became infected in the ward (see table) and those which -were already infected with this organism on admission.Of the latter there were in all in the first period 3 (2 in the Table showvinig Inicidenice of Hospital Ilnfectionz of Head Wolunids wtsith Strep.pyogenies in Two Four-mionth Periods, before anid after Introduictioni of Improved Dressing Technique 1st Period 2nd Period Air-raid casualty wounds: Numnber uninfected on admission. .32 46 Number of hospital infections .. 10 Percentage incidence of hospital infection 31-32 2 "Clean" operation wounds: Number operated upon 46 49 Number of hospital infections -2 0 Percentage incidence of hospital infection 4-4 0.0male ward and 1 in the female ward), and in the second period 11 (5 in the male ward, 6 in the female ward); therefore, including the patients infected on admission, there were altogether 15 streptococcal wounds in the first period and 15 in the second period.
CQC says it failed to respond adequately to concerns about care home deaths
Authors: S. Mayor
Journal: BMJ (2014)

The Care Quality Commission failed to respond to early warning signs of problems and took too long to recognise and act on risks to residents at a care home in West Sussex. An inquest subsequently found that neglect had contributed to the deaths of five people there and that other residents experienced “suboptimal” care, the CQC has found in an analysis of its role in the case.1

The CQC’s report comes after a serious case review carried out by West Sussex Adults Safeguarding Board that found that the CQC’s assessment of the care home, Orchid View, …
A new indication for double-balloon enteroscopy: removal of migrated metal stents through a Roux-en-Y anastomosis
Authors: Y. Chu, Y. Yeh, C. Yang, C. Chen, S. Yueh, L. Mo
Journal: Endoscopy (2007)

The rate of migration of metal stents is very low, but stents can be technically very difficult to remove if the patient has previously undergone biliary Roux-en-Y surgery. We report here on a case in which a migrated metal stent was removed using double-balloon enteroscopy - a new indication for the latter procedure.
Australia set for class action against tobacco industry
Authors: G. Kenyon
Journal: BMJ (1999)

A class action against three tobacco companies has been filed at Australia's Federal Court by a group of Australians claiming to have been injured as a direct result of smoking. The representative action against the companies-WD & HO Wills, Philip Morris Australia, and Rothmans-is due to be heard at the end of April this year.

An antismoking lobby group, Action on Health and Smoking (AHS), approached a Sydney barrister, John Rowe, …
Austrian medical schools fear influx of German students
Authors: Tuffs Annette
Journal: BMJ (2005)

With most German universities planning to charge fees from 2007, medical schools in neighbouring Austria are worried that they will be deluged with German applicants.

The move in Germany follows a recent decision by the Federal Constitutional Court at the end of January, which entitled universities to raise tuition fees for all subjects.

For the past 40 years, university tuition in Germany has been free. Already, about half of the German federal states, including Bavaria …