THE EFFECTIVENESS OF ACETYL-B-METHYLCHOLINE GIVEN BY MOUTH AS A VASODILATING AGENT
Authors: Grace A. Goldsmith
Journal: Annals of Internal Medicine (1936)

Article1 March 1936THE EFFECTIVENESS OF ACETYL-B-METHYLCHOLINE GIVEN BY MOUTH AS A VASODILATING AGENTGRACE A. GOLDSMITH, M.D.GRACE A. GOLDSMITH, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-9-9-1196 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptCholine and its compounds have been investigated extensively in recent years. Acetylcholine was first prepared by Baeyer in 1867 but remained of chemical interest only until Hunt and Taveau in 1906 noted its marked physiologic activity. Both choline and acetylcholine have been isolated from animal tissues, Dale obtaining the latter in pure chemical form in 1929. Acetylcholine owes its present importance to the almost certain proof that it is the chemical intermediary between parasympathetic nerve stimulation and tissue response (Dale and Alles).Acetylcholine has three important actions: (1) a parasympathetic effect, inhibiting cardiac action and increasing intestinal tonus; (2) a...Bibliography1. ALLES GA: The physiological significance of choline derivatives, Physiol. Rev., 1934, xiv, 276-304. CrossrefGoogle Scholar2. BAEYER : Quoted by Alles. Google Scholar3. COMROESTARR JHI: Further studies on the pharmacology of acetyl-B-methylcholine and the ethyl ester of B-methylcholine, Jr. Pharmacol. and Exper. Therap., 1933, xlix, 283-299. Google Scholar4. DALE H: Chemical transmission of the effects of nerve impulses, Brit. Med. Jr., 1934, l, 835-841. CrossrefGoogle Scholar5. HINESBROWN EAGE: A standard test for measuring the variability of blood pressure: its significance as an index of the prehypertensive state, ANN. INT. MED., 1933, vii, 209-217. Google Scholar6. HUNTTAVEAU : Quoted by Dale. Google Scholar7. KOVACSKOVACS RJ: Newer aspects of iontophoresis for arthritis and circulatory disturbances, Arch. Phys. Therapy, 1934, xv, 593-598. Google Scholar8. MAJOR : Quoted by Alles. Google Scholar9. PAGE IH: Acetyl-B-methylcholine (mecholin); observations concerning its action on blood pressure, skin temperature and heart, as exhibited by electrocardiogram of hypertensive patients, Am. Jr. Med. Sci., 1935, clxxxix, 55-64. CrossrefGoogle Scholar10. SIMONART : Quoted by Alles. Google Scholar11. STARR I: Acetyl-B-methylcholine: III. Its action on paroxysmal tachycardia and peripheral vascular disease, with a discussion of its action in other conditions, Am. Jr. Med. Sci., 1933, clxxxvi, 330-345. CrossrefGoogle Scholar12. STARRELSOMREISINGER IKAJA: Acetyl-B-methylcholine. I. The action on normal persons, Am. Jr. Med. Sci., 1933, clxxxvi, 313-323. CrossrefGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Rochester, Minnesota*Submitted for publication August 16, 1935.From the Mayo Clinic, Rochester, Minnesota. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byCIRCULATORY EFFECTS OF SUCCINYLCHOLINE IN MANThe effect of drugs on the surface capillaries of the macaca rhesusAcetyl-Beta-Methylcholine as a Therapeutic Agent 1 March 1936Volume 9, Issue 9Page: 1196-1202KeywordsAcetylcholineMouthNerves Issue Published: 1 March 1936 PDF downloadLoading ...