PICROTOXIN IN THE TREATMENT OF ACUTE BARBITURATE POISONING; A REVIEW OF THE LITERATURE WITH REPORT OF TWO CASES
Authors: Edward C. Reifenstein, Justin W. Mignault, Angelo J. Raffaele
Journal: Annals of Internal Medicine (1939)

Article1 December 1939PICROTOXIN IN THE TREATMENT OF ACUTE BARBITURATE POISONING; A REVIEW OF THE LITERATURE WITH REPORT OF TWO CASESEDWARD C. REIFENSTEIN JR., M.D., EDWARD C. REIFENSTEIN SR., M.D., F.A.C.P., JUSTIN W. MIGNAULT, M.D., ANGELO J. RAFFAELE, M.D.EDWARD C. REIFENSTEIN JR., M.D.Search for more papers by this author, EDWARD C. REIFENSTEIN SR., M.D., F.A.C.P.Search for more papers by this author, JUSTIN W. MIGNAULT, M.D.Search for more papers by this author, ANGELO J. RAFFAELE, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-13-6-1013 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptAcute poisoning with barbituric acid compounds ranks today as one of the commonest forms of acute drug intoxication; therefore, it has become a necessity for physicians to be familiar with the most satisfactory methods of treating this condition. A review of the recent clinical reports in the literature seems to indicate that picrotoxin, properly employed, is at present the most successful antidote for barbiturate poisoning. Table 1 summarizes the data of the cases in these reports. To them we are adding the two cases herein recorded, one of which is of unusual interest because the patient recovered after the ingestion...References SUPPLEMENTARY REFERENCES1. KOPPANYIMURPHYKROP TWSS: Colorimetric determination of barbital and its applications, Proc. Soc. Exper. Biol. and Med., 1933, xxx, 542-544. CrossrefGoogle Scholar2. ARNETT JH: Ephedrine and picrotoxin used successfully in amytal poisoning, Jr. Am. Med. Assoc., 1933, c, 1593. CrossrefGoogle Scholar3. MURPHYCONNERTYCONNOLLYKOPPANYI WSHVAJT: Studies on barbiturates. XVI. Barbiturate poisoning treated with picrotoxin, Jr. Lab. and Clin. Med., 1937, xxii, 350-356. Google Scholar4. VOLPITTO PP: Picrotoxin as an antidote in acute poisoning from barbituric acid derivatives, Trans. 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WYNNE, M.D., DONALD M. HASKINS, M.D.The present status of analeptics * *From The George Washington University, School of Pharmacy, Washington, D. C. † †This is the sixth of a series of review articles. Part of the cost of publication of this series of review articles is paid from the treasury of the National Conference on Pharmaceutical Research. 1 December 1939Volume 13, Issue 6Page: 1013-1027KeywordsAntidotesDrugsIngestionIntoxication ePublished: 1 December 2008 Issue Published: 1 December 1939 PDF downloadLoading ...