tbuckley/cabot-search huggingface dataset:
STAMMERING AS AN IMPEDIMENT OF THOUGHT
Authors: C. S. BLUEMEL
Journal: JAMA (1931)

If ten men, working with hammers, happen to strike their thumbs, these ten subjects, responding to the same stimulus, will react differently. For the purpose of this discussion, let it be presumed that their reactions are as follows: The first man inspects his thumb. The second sticks his thumb in his mouth. The third wraps his thumb in his handkerchief. The fourth waves his injured hand in the air. The fifth gesticulates with the hammer. The sixth flings the hammer to the ground. The seventh swears. The eighth counts in order not to swear. The ninth whistles. The tenth faints. Here is rich material for investigation. But what if the investigators come on the scene a little late; they have seen the man's reaction, but they have not seen him strike his thumb. It is therefore the reactions that they proceed to investigate. Being earnest and diligent, they pursue their
Diet and Diseases of the Colon
Authors: Thoburn F. Thompson
Journal: JAMA (1976)

<h3>To the Editor.—</h3> In response to the editorial on "Fiber Feeding—Fad or Finger of Fate?" (235:182, 1976), I would like to mention that the occurrence of diseases of the colon in La Paz, Bolivia, is very much like that in other underdeveloped regions of the world.<sup>1,2</sup>As a general surgeon working in an acute general hospital and as a surgeon having practiced privately in the United States, I have observed the relative rarity of cancer of the large intestine, adenomatous polyps, ulcerative colitis, diverticulitis, and even large-vessel arteriosclerosis.<sup>3</sup>Most of our patients cannot afford refined foods, high-fat diets, or more than an occasional cigarette. Although it is difficult to identify contributing factors scientifically, such epidemiological observations are important, based on clinical findings, impressions and autopsy material. We would agree with the social inconveniences of increased flatulence, frequent borborygmi, and frequent stools associated with a high-bulk diet. A more
Report of Autopsy on Assassin Disclaimed.
Authors: Edward A. Spitzka
Journal: JAMA (1901)

New York City, Nov. 2, 1901. <h3>To the Editor:</h3> —It has come to my knowledge that an account purporting to be a report of the autopsy performed upon the assassin Czolgosz has in a manner been placed upon the market and offered to various medical journals. To prevent other periodicals from being misled I beg to inform you that no authentic report has as yet been issued, and that none is authentic or reliable unless signed by Dr. Carlos F. MacDonald or myself, or both jointly. Since the alleged report is based upon a series of disjointed data dictated by me to a stenographer in whom I reposed confidence and who had no permission to give out any portion of it, it is necessarily valueless and unintelligible and possibly misleading. As may be readily understood, these notes were made as aids to the memory and to supplement other notes in
Would-be cheats face barrage of tests at London Olympics
Authors: M. Hunter
Journal: BMJ (2011)

London’s 2012 Olympic Games will be the “riskiest” ever for drug cheats, says the man charged with leading the antidoping programme for the event.

Athletes will face new tests for growth hormone, gene doping, and possibly autologous blood doping, where an athlete’s own blood is extracted, stored, then reintroduced at a later date. An army of 150 antidoping scientists will carry out the tests, supported by around 80 science graduates drafted in as temporary assistant analysts. Also, far greater use will be made of “targeted testing” on the basis of intelligence gathered before the games.

David Cowan, director of the …
A potential role for genes in asthma independent of atopy
Authors: Unnur Steina Bjornsdottir, Hildur Helgadóttir, Eva Halapi, Elva Adalsteinsdottir, Asta Solilja Gudmundsdottir, Illugi Birkisson, Thor Arnason, Sigurdur Ingvarsson, Margret Andresdottir, David Gislason
Journal: Journal of Allergy and Clinical Immunology (2002)
Problems with sexual function: Training in psychosexual medicine is available for doctors
Authors: J. Whitmore
Journal: BMJ (2003)

EDITOR—The lack of undergraduate and postgraduate training in managing sexual problems is one reason for the under-recording in general practice notes of consultations about sexual problems.1 The medical model of history, examination, diagnosis, and treatment is a poor tool when faced with “dysfunction” of what is fundamentally a psychosomatic event–sexual activity and orgasm.

This is …
Dietary micronutrients/antioxidants and their relationship with bronchial asthma severity
Authors: C. Picado, R. Deulofeu, R. Lleonart, M. Agustí, J. Mullol, M. Torra, L. Quintó
Journal: Allergy (2001)

Background: Because little is known about micronutrient/antioxidant intake and asthma severity, we investigated dietary intake and plasma/serum levels of micronutrients/antioxidants in a group of asthma patients with various degrees of severity, and compared the results with healthy subjects. Methods: A case control study was carried out on 118 asthma patients and 121 healthy subjects. The severity of the disease was classified by division of patients into four groups. Normal dietary micronutrient/antioxidant intake was estimated from a food frequency questionnaire. Plasma/serum levels of vitamins C, E, and A, selenium, magnesium, zinc, and platelet glutathione peroxidase (GSH‐Px) activity were also determined. Results: No differences in daily micronutrient/antioxidant intake were seen between patients and healthy subjects. The severity of the disease showed no significant relationship with micronutrient/antioxidant intake. There were no differences in plasma/serum levels in any of the micronutrients/antioxidants between healthy subjects and asthmatics. Nor were any differences found between asthma groups in severity in the biochemical measures, except in platelet GSH‐Px activity, which was significantly lower in the most severe groups. Conclusions: In this study, we found no evidence of any association between micronutrient/antioxidant intake or plasma/serum levels of micronutrients/antioxidants and asthma. Reduction of platelet GSH‐Px activity in the most severe patients suggests that these patients have a diminished capacity to restore part of the antioxidant defences.
Onset of palmar sweating in newborn infants
Authors: JULIAN VERBOV, JANE BAXTER
Journal: British Journal of Dermatology (1974)

Journal Article Onset of palmar sweating in newborn infants Get access JULIAN VERBOV, JULIAN VERBOV Mill Road Maternity Hospital, Liverpool L6 2AH Requests for reprints should be sent to Dr Verbov, Department of Dermatology, University of Liverpool, Liverpool Royal Infirmary, Liverpool L3 5PU. Search for other works by this author on: Oxford Academic Google Scholar JANE BAXTER JANE BAXTER Mill Road Maternity Hospital, Liverpool L6 2AH Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 90, Issue 3, 1 March 1974, Pages 269–276, https://doi.org/10.1111/j.1365-2133.1974.tb06401.x Published: 01 March 1974 Article history Accepted: 10 July 1973 Published: 01 March 1974
Cardiac Myocytes Produce Interleukin-6 in Culture and in Viable Border Zone of Reperfused Infarctions
Authors: Marianne Gwechenberger, Leonardo H. Mendoza, Keith A. Youker, Nikolaos G. Frangogiannis, C. Wayne Smith, Lloyd H. Michael, Mark L. Entman
Journal: Circulation (1999)

Background —Previous work from our laboratory demonstrated that interleukin (IL)-6 plays a potentially critical role in postreperfusion myocardial injury and is the major cytokine responsible for induction of intracellular adhesion molecule (ICAM)-1 on cardiac myocytes during reperfusion. Myocyte ICAM-1 induction is necessary for neutrophil-associated myocyte injury. We have previously demonstrated the induction of IL-6 in the ischemic myocardium, and the current study addresses the cells of origin of IL-6. Methods and Results —In the present study, we combined Northern blot analysis and in situ hybridization to demonstrate IL-6 gene expression in cardiac myocytes. Isolated ventricular myocytes were stimulated with tumor necrosis factor-α, IL-1β, lipopolysaccharide, preischemic lymph, and postischemic lymph. Unstimulated myocytes showed no significant IL-6 mRNA expression. Myocytes stimulated with preischemic lymph showed minimal or no IL-6 mRNA expression, whereas myocytes stimulated with tumor necrosis factor-α, IL-1β, lipopolysaccharide, or postischemic lymph showed a strong IL-6 mRNA induction. Northern blot with ICAM-1 probe revealed ICAM-1 expression under every condition that demonstrated IL-6 induction. We then investigated the expression of IL-6 mRNA in our canine model of ischemia and reperfusion. Cardiac myocytes in the viable border zone of a myocardial infarction exhibited reperfusion-dependent expression of IL-6 mRNA within 1 hour after reperfusion. Mononuclear cells infiltrate the border zone and express IL-6 mRNA. Conclusions —Isolated cardiac myocytes produce IL-6 mRNA in response to several cytokines as well as postischemic cardiac lymph. In addition to its production by inflammatory cells, we demonstrate that IL-6 mRNA is induced in myocytes in the viable border zone of a myocardial infarct. The potential roles of IL-6 in cardiac myocytes in an infarct border are discussed.
Geographic tongue—a manifestation of atopy
Authors: ROBIN MARKS, MALCOLM J. SIMONS
Journal: British Journal of Dermatology (1979)

One hundred patients with geographic tongue have been studied for evidence of an association with atopy. There was a significantly high frequency of personal and/or family history of asthma, eczema and hay fever amongst the patients when compared to a control population. A raised total serum IgE( greater than or equal to 200 u/ml) was significantly more frequent in patients compared to a control population. These findings confirm the impression that in some patients geographic tongue is a sign of atopy.
Central hemodynamics during lung recruitment maneuvers at hypovolemia, normovolemia and hypervolemia. A study by echocardiography and continuous pulmonary artery flow measurements in lung-injured pigs
Authors: Jonas Nielsen, Manja Nilsson, Filip Fredén, Jan Hultman, Ulrica Alström, Jesper Kjærgaard, Göran Hedenstierna, Anders Larsson
Journal: Intensive Care Medicine (2006)
Hyperpigmentation of Skin
Authors: S. J. Baker, M. Ignatius, S. Johnson, S. K. Vaish
Journal: BMJ (1963)

<h3>Background</h3> High-frequency, remote assessments of cognitive and motor symptoms in neurodegenerative diseases using smartphones have the potential to monitor disease progression and therapeutic interventions. Here, we report the digital EQ-5D-5L survey results from GENERATION HD1 (NCT03761849). <h3>Aim</h3> To compare changes in self-reported QoL between tominersen treatment arms (120 mg every 8 [Q8W] and 16 weeks [Q16W]) versus placebo using the EQ-5D-5L survey from the Roche HD digital monitoring platform. <h3>Methods/Techniques</h3> Survival analysis of QoL progression was performed using the time of sustained reported worsening as events up until Week 69. Survival curves were compared between Q8W, Q16W and placebo arms, which were split into low- versus high-age (&lt;48 vs. ≥48 years), and low- or high-CAG-age product (CAP) score (&lt;500 vs. ≥500) subgroups. For the visual analogue scale (VAS) score, a worse response was defined as a 10-point decrease. <h3>Results/Outcome</h3> A consistent favourable trend was observed across motor-related EQ-5D-5L items, as well as the index and VAS score, in the Q16W low-age subgroup compared with placebo. The effect was more pronounced in the Q16W low-age, low-CAP subgroup, was substantially weaker in the Q8W low-age, low-CAP subgroup and was not observed in any high-age subgroups. <h3>Conclusions</h3> High-frequency self-reporting of QoL enables sensitive survival analyses of treatment effects. Individuals in the Q16W low-age, low-CAP subgroups appeared to sustain their QoL for longer than placebo, consistent with findings from an exploratory post hoc analysis showing that tominersen may have potential benefits in this subgroup.<sup>1</sup> <h3>Disclosures Statement</h3> GENERATION HD1 was funded by F. Hoffmann-La Roche Ltd. Medical writing support was provided by Chrysalis Medical Communications and funded by F. Hoffmann-La Roche Ltd. <h3>Reference</h3> McColgan P, et al. <i>17<sup>th</sup> Annual HD Therapeutics Conference</i>. 2022.
Liver sinusoidal endothelial cell progenitor cells promote liver regeneration in rats
Authors: Lin Wang, Xiangdong Wang, Guanhua Xie, Lei Wang, Colin K. Hill, Laurie D. DeLeve
Journal: Journal of Clinical Investigation (2012)

The ability of the liver to regenerate is crucial to protect liver function after injury and during chronic disease. Increases in hepatocyte growth factor (HGF) in liver sinusoidal endothelial cells (LSECs) are thought to drive liver regeneration. However, in contrast to endothelial progenitor cells, mature LSECs express little HGF. Therefore, we sought to establish in rats whether liver injury causes BM LSEC progenitor cells to engraft in the liver and provide increased levels of HGF and to examine the relative contribution of resident and BM LSEC progenitors. LSEC label-retaining cells and progenitors were identified in liver and LSEC progenitors in BM. BM LSEC progenitors did not contribute to normal LSEC turnover in the liver. However, after partial hepatectomy, BM LSEC progenitor proliferation and mobilization to the circulation doubled. In the liver, one-quarter of the LSECs were BM derived, and BM LSEC progenitors differentiated into fenestrated LSECs. When irradiated rats underwent partial hepatectomy, liver regeneration was compromised, but infusion of LSEC progenitors rescued the defect. Further analysis revealed that BM LSEC progenitors expressed substantially more HGF and were more proliferative than resident LSEC progenitors after partial hepatectomy. Resident LSEC progenitors within their niche may play a smaller role in recovery from partial hepatectomy than BM LSEC progenitors, but, when infused after injury, these progenitors engrafted and expanded markedly over a 2-month period. In conclusion, LSEC progenitor cells are present in liver and BM, and recruitment of BM LSEC progenitors is necessary for normal liver regeneration.
Factors affecting development of peritonitis in continuous ambulatory peritoneal dialysis.
Authors: T H Goodship, A Heaton, R S Rodger, M K Ward, R Wilkinson, D N Kerr
Journal: BMJ (1984)

A questionnaire based survey in patients receiving continuous ambulatory peritoneal dialysis showed that there was an increased incidence of upper respiratory tract symptoms (suggestive of viral illness) in the 14 days before the development of peritonitis. No other factors were identified that might distinguish patients who develop peritonitis. The possibility that viral infections predispose to peritonitis by altering host defence mechanisms in patients receiving this form of renal replacement therapy warrants further study.
Association of bacteria and viruses with wheezy episodes in young children: prospective birth cohort study
Authors: H. Bisgaard, M. N. Hermansen, K. Bonnelykke, J. Stokholm, F. Baty, N. L. Skytt, J. Aniscenko, T. Kebadze, S. L. Johnston
Journal: BMJ (2010)

<b>Objective</b> To study the association between wheezy symptoms in young children and the presence of bacteria in the airways. <b>Design</b> Birth cohort study. <b>Setting</b> Clinical research unit in Copenhagen. <b>Participants</b> Children of asthmatic mothers, from age 4 weeks to 3 years, with planned visits and acute admissions to the research clinic. <b>Main outcome measure</b> Frequency of bacteria and virus carriage in airway aspirates during wheezy episodes and at planned visits without respiratory symptoms. <b>Results</b> 984 samples (361 children) were analysed for bacteria, 844 (299 children) for viruses, and 696 (277 children) for both viruses and bacteria. Wheezy episodes were associated with both bacterial infection (odds ratio 2.9, 95% confidence interval 1.9 to 4.3; P&lt;0.001) and virus infection (2.8, 1.7 to 4.4; P&lt;0.001). The associations of bacteria and viruses were independent of each other. <b>Conclusion</b> Acute wheezy episodes in young children were significantly associated with bacterial infections similar to but independent of the association with virus infections.
Reformulation of the Sedation Continuum
Authors: Steven M. Green
Journal: JAMA (2010)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
On Awakening Paralyzed During Surgery
Authors: C. Philip Larson
Journal: JAMA (1976)

To the Editor.—  While one or more cases reported by Dr Blacher (234:67, 1975) may represent the consequences of inadequate sensory anesthesia during operation, it should be emphasized that there are other more plausible explanations for the observations reported. For example, the kinds of feelings and sensations reported by Dr Blacher's patients could have developed in the postanesthesia recovery room during the course of emergence from anesthesia. The types of drugs used for anesthesia in the cases reported (ie, barbiturates, opiates, and tranquilizers) generally lead to a gradual emergence and hence ample opportunity for the sensations described to develop. Since the same types of drugs are used for premedication, it is also reasonable to expect that some of these patients' neurotic experiences occurred in the preoperative period.  It is important to emphasize that Dr Blacher presented no evidence documenting postsurgical neuroses as a result of inadequate anesthesia during operation. No
Panniculitis during Dasatinib Therapy for Imatinib-Resistant Chronic Myelogenous Leukemia
Authors: Sarit Assouline, Pierre Laneuville, Carlo Gambacorti-Passerini
Journal: New England Journal of Medicine (2006)

To the Editor: We describe two cases of panniculitis apparently caused by dasatinib. In one, management after the diagnosis of the panniculitis allowed dasatinib therapy to be continued. In the first case, a 55-year-old woman (Patient 1) presented in the chronic phase of chronic myelogenous leukemia (CML) and did not have a major cytogenetic response (defined by the presence of the Philadelphia chromosome in <35 percent of cells in metaphase) to imatinib mesylate at a dose of 800 mg daily. She was known to have the activation-loop mutation H396R, which is associated with resistance to imatinib.1 She entered a phase . . .
Epoprostenol now the focus of numerous clinical trials
Authors: William A. Check
Journal: JAMA (1981)

Evidence is fast accumulating on the therapeutic value of one of the newest members of the prostaglandin family, epoprostenol, which was discovered in 1976. In the United States recently to deliver a lecture, John Vane, DSc, group research director at the Burroughs Wellcome Foundation, Beckenham, England, described for<i>JAMA</i>MEDICAL NEWS some of the clinical trials in which the compound has proved its value as an inhibitor of platelet aggregation. Vane received the Lasker Award in 1977 for his prominent role in the discovery of epoprostenol, also known as PGI2 and more commonly as prostacyclin. Other information on epoprostenol comes from a recent conference on prostaglandins in cerebrovascular and thrombotic disorders held in Chicago under the auspices of Rush Medical College and Northwestern University Medical School. Epoprostenol was actually discovered by Vane and Salvador Moncada during their search for thromboxane, the prostaglandin that<i>promotes</i>aggregation of platelets, in the endothelium
Textbook of Disturbances of Mental Life, or Disturbances of the Soul and Their Treatment
Authors: Thomas H. Jobe
Journal: JAMA (1976)

This fluent, highly readable text, the first English translation of Johann Christian Heinroth's famous<i>Lehrbuch der Störungen des Seelenlebens</i>, will hold special interest for those interested in the philosophical aspects of psychiatry. Heinroth's textbook generated a heated controversy between the psychic and somatic schools of psychiatry in Germany when it was published in 1818. Although he acknowledged that there were organic causes of insanity, Heinroth, physician and philosopher, sought to give medical psychology a philosophic foundation based on the then-prevalent German<i>Naturphilosophie</i>. He held that the essential quality of the human spirit was freedom, and that freedom was different from nature and often conflicted with it. Reason, the instrument of God, mediated between Man and Nature. As long as man subordinated spirit to Reason by an act of will, he could live a good and sane existence in harmony with Nature. If he refused, he would be trapped in the