tbuckley/cabot-search huggingface dataset:
A Study of Atrophic Cirrhosis of the Liver in Relationship to Syphilis
Authors: Don M. Leduc
Journal: Annals of Internal Medicine (1929)

Article1 March 1929A Study of Atrophic Cirrhosis of the Liver in Relationship to SyphilisDON M. LEDUCDON M. LEDUCSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-2-9-932 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThis paper comprises a review of all cases of cirrhosis of the liver which have occurred in the pathology service of the University of Michigan from the year 1895 through the major part of the year 1925, with the exception of all cases of central cirrhosis, biliary cirrhosis, fatty cirrhosis, and four cases that could not be definitely classified. Special emphasis is placed upon the concomitant presence of histological evidence of syphilis, either in the liver, or elsewhere in the body.An exhaustive resumé of the literature was not attempted. Cirrhosis of the liver was described as a hardening of...References(1) ROLLESTON : Diseases of the Liver, p. 178. Google Scholar(2) PAYNE : Trans. Path. Soc., vol. xl, p. 310. Google Scholar(3) HAWKINS : Albut and Rolleston's System of Med., vol. iv, pt. 1, p. 173. Google Scholar(4) SYMMERS : Internat. Clin., vol. 1, p. 58. Google Scholar(5) OPIE : Journ. of Exp. Med., vol. xii, No. 3, p. 367. CrossrefGoogle Scholar(6) FORMAD : Trans. Assn. Am. Phys., vol. i, p. 225. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Ann Arbor, Michigan*From the Pathological Laboratory, University of Michigan, Ann Arbor, Michigan. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byHepatic syphilis: An historical reviewTRAVELLERS' DIARRHŒASYPHILIS AND HEPATIC CIRRHOSISThe association of syphilis with hepatic cirrhosis: a report of six cases and a review of the literatureREFERENCES 1 March 1929Volume 2, Issue 9Page: 932-935KeywordsCirrhosisLiverResearch laboratoriesSyphilis ePublished: 1 December 2008 Issue Published: 1 March 1929 PDF downloadLoading ...
Catalytic activity of antibodies against factor VIII in patients with hemophilia A
Authors: Sébastien Lacroix-Desmazes, Alexandre Moreau, None Sooryanarayana, Cécile Bonnemain, Natalie Stieltjes, Anastas Pashov, Yvette Sultan, Johan Hoebeke, Michel D. Kazatchkine, Srinivas V. Kaveri
Journal: Nature Medicine (1999)
Analysis of the functional integrity of p53 tumor suppressor gene in malignant melanoma
Authors: Andreas Knopf
Journal: Clinical Cancer Research (2008)

A11   Malignant melanomas (MM) are aggressive tumors characterized by high resistency for chemotherapy and poor patient prognosis. Derogation of the p53 pathway is a hallmark in many human malignancies; accumulation of the p53 protein implies disturbance of its functional integrity. However its implication in MM remains unclear. p53 accumulation is a frequent event in MM despite protein stabilizing mutations are rare. We hypothesized that posttranslational modifications or aberrant expression of p53 modifier genes are possible mechanisms yielding p53 accumulation. Therefore, we investigated p53 protein- and mRNA-stability and the expression of two p53 modifier genes, MDM2 and HIPK2. In addition, the expression of p53 mRNA and protein as well as three p53 target genes (p21, GADD45, and CDC2) were analyzed before and after UV-irradiation and treatment with cisplatin (cis) and dacarbazine (dac).  For the study we used native melanocytes, 3 MM cell lines expressing wild-type p53, and 3 MM cell lines harbouring p53 mutations. Real-time RT-PCR and Western blot experiments were conducted before and after induction with cis in order to determine p53 protein and mRNA-stability. Transcript expression of MDM2, HIPK2, p21, GADD45A and CDC2 was analyzed via macro-arrays. Differences in gene expression were validated using real-time RT-PCR. p53 accumulation was determined after UV-B and -C irradiation or treatment with cis or dac using Western blot.  67% of MM showed high constitutive p53 protein levels. MM and native melanocytes displayed high p53 protein stability. p53 transcripts remained stable in most of the MM cell lines. Before and after UV-irradiation MDM2 mRNA expression was higher for melanocytes compared to MM. We detected high HIPK2 mRNA levels in MM expressing mutant p53. UV-irradiated and chemotherapy-treated melanocytes showed a higher expression of p21 and GADD45A and a lower expression of CDC2 compared to MM.  Our findings suggest that high p53 protein expression is due to posttranslational modification or aberrant expression of p53 modifier genes, and that accumulated p53 protein is functionally disrupted. Our data highlight that the dysfunction of the p53 pathway is of major impact in the carcinogenesis of MM.
CLIMATE, MODE OF LIFE, AND HEART DISEASE
Authors: Paul D. White
Journal: Annals of Internal Medicine (1938)

Article1 July 1938CLIMATE, MODE OF LIFE, AND HEART DISEASEPAUL D. WHITE, F.A.C.P.PAUL D. WHITE, F.A.C.P.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-12-1-6 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptArm chair philosophy in medicine has its place, but without rich experience and wisdom it can play but a minor rôle; it is wise to spend less time discussing our impressions and more time in testing their real truth.In the field of heart disease we have been notably backward in studying carefully the results of nature's own experiments on man the world over. These clues to knowledge await us everywhere. Let me ask you some of the questions that are crying for solution.Is it really true that coronary disease, especially early atheroma and thrombosis, is becoming more and...Bibliography1. PEARL R: Tobacco smoking and longevity, Science, 1938, lxxxvii, 216. CrossrefGoogle Scholar2. WILBUR RL: March of medicine, Science, 1938, lxxxvii, 199. CrossrefGoogle Scholar3. MCKINLEY : A geography of disease, George Washington University Press, Washington, D. C., 1935. Google Scholar4. The Annual Report of the Sanitary Bureau of the Home Department of the Imperial Japanese Government for the 10th Year of Showa (1935), Tokyo, 1937. Google Scholar5. WHITEJONES PDTD: Heart disease and disorders in New England, Am. Heart Jr., 1928, iii, 302. CrossrefGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Boston, Massachusetts*Read before the American College of Physicians, New York, April 5, 1938. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byFailing Cardiovascular HealthUnexpected post-partum hypertensionActivities associated with the onset of acute coronary artery occlusion 1 July 1938Volume 12, Issue 1Page: 6-12KeywordsAtheromasCardiovascular therapyStable coronary artery diseaseThrombosis ePublished: 1 December 2008 Issue Published: 1 July 1938 PDF downloadLoading ...
TREATMENT OF NONTUBERCULOUS BACTERIAL PLEURAL SPACE INFECTIONS WITH AUREOMYCIN: RESULTS OF TREATMENT IN NINE PATIENTS; CONCENTRATION OF AUREOMYCIN IN PLEURAL AND PERICARDIAL FLUID IN SEVEN PATIENTS
Authors: C K WOLFE, M H LEPPER, E R CALDWELL, H W SPIES, H F DOWLING
Journal: Annals of Internal Medicine (1952)

Excerpt During the last few years the appearance of several agents effective in the treatment of bacterial pulmonary infections has diminished the frequency of nontuberculous pleural space infectio...
Promoter hypermethylation of cancer-related genes: a strong independent prognostic factor in acute lymphoblastic leukemia
Authors: Jose Roman-Gomez, Antonio Jimenez-Velasco, Juan A. Castillejo, Xabier Agirre, Manuel Barrios, German Navarro, Francisco J. Molina, Maria J. Calasanz, Felipe Prosper, Anabel Heiniger, Antonio Torres
Journal: Blood (2004)
Quit smoking in pregnancy with asthma
Authors: Olga Sukhovskaya, Olga Lavrova, Natalia Kolpinskaya
Journal: European Respiratory Journal (2011)

The aim of this study was to identify the factors related to quit smoking during pregnancy in patients with asthma. The sample included 990 pregnants (417 with asthma) in age 18-40 years. They were interviewed about smoking and social status. CO breath testing has been made for cigarette consumption.  Investigation shows that 26.4% pregnants without asthma were smokers (6.95±0.94 cigarette per day), 23% pregnants with asthma were smokers (7.06±1.2 cigarette per day). Before pregnancy women smoked in 57.1% cases without asthma (11.3±1.6 cigarette per day) and in 49.4% with asthma (10.6±1.7 cigarette per day). Education programs were organized for pregnats with asthma. Health pregnants quit smoking in 14.7+1.9 week of pregnancy, patients with asthma – in 8.77+1.2 week. The cessation smoking program included of CO level measuring. The discrepancy of answers and CO levels was in 22% of cases.  The factors, promotional quit smoking during pregnancy were: educational programs for smokers, non-smoking family (especially husband), high education, support of husband in quit smoking. Unmarried pregnants smoked twice more often than married women. Planned pregnancy contributed to smoking rejection, so amount of smoking females was one and a half time smaller in comparison with females with unplanned pregnancy. The number of women who had more than one child was higher among non- smokers and abstinent smokers than among smokers (p=0.004).   Conclusion:  Smoking was founded in women with asthma so often as without asthma. Pregnancy is a main factor to smoking cessation for women. Several factors influence smoking cessation were: the educational programs for smoking, non smoking their partners, marriage, high education, planned pregnancy.
290. Demonstration of Antitumor Efficacy with an Oncolytic Adenovirus CG8840 for the Treatment of Bladder Cancer in an Orthotopic Tumor Model in Mice
Authors: Nagarajan Ramesh, Ying Ge, Jun Liu, Deborah Farson, Melinda Van Roey, Virginia Rojas, DeChao Yu
Journal: Molecular Therapy (2004)
Abstract 12222: Use of a Reminder Statement on Echocardiography Reports Increases Appropriate Referral for Implantable Cardioverter-Defibrillators for Primary Prevention
Authors: Moulin Chokshi, Robert L McNamara, Yasotha Rajeswaran, Rachel Lampert
Journal: Circulation (2014)

Background:  Numerous trials have shown the benefit of ICDs for primary prevention in patients with low EF and history of CHF, and guidelines recommend their use. Still, underutilization is well-documented.   Hypothesis:  Placing a reminder statement into echocardiogram reports for appropriate patients will increase adherence to guidelines.   Methods:  From January to June 2013, a brief statement reminding clinicians of the ICD guidelines was automatically inserted into the body of echocardiogram reports for patients with an EF ≤ 35% at a single center (intervention group). Charts were reviewed to determine if these patients were 1) referred to EP and 2) received an ICD, within six months. We reviewed medical records of all patients with the same criteria between March and August 2012 to establish a historical control group. Patients were considered inappropriate for EP referral if they had an ICD, repeat echo within 6 months of index echocardiogram with an EF>35%, expired within 6 months, end stage disease, dementia, refused an ICD in the past, had a DNR order, or had class IV heart failure with a QRS   Results:  There was a significant increase in appropriate EP referrals in the intervention group compared with the control, 76.1% versus 58.9% (p = 0.03). Among patients appropriate for ICD, 57.9% of patients in the intervention group received an ICD versus 44.2% of controls (p = 0.13). Referral of inappropriate patients to EP did not increase (see Table).   Conclusions:  A simple reminder statement on echocardiography reports led to a significant increase in appropriate EP referrals and a trend towards increased ICD implantation in appropriate patients. This essentially free quality improvement intervention improves adherence to ICD guidelines.
Emergency Medicine: Concepts and Clinical Practice.
Authors: Peter Rosen
Journal: Annals of Internal Medicine (1988)

Part I: General Concepts. Resuscitation. Practice of Emergency Medicine. Anesthesia and Pain Management. EMS. Part II: Trauma. General Concepts. Head and Spinal Trauma. Chest Trauma. Abdominal Trauma. Orthopedic Trauma. Soft Tissue Trauma. Part III: Environmental Disorders. Part IV: Selected Pediatric Problems. General Concepts, Cardiopulmonary Disorders. Gastrointestinal Disorders. Neurological Disorders. Part V: Toxicologic Problems. Part VI: Systemic Disorders. Respiratory Disorders. Cardiac Disorders. Vascular Disorders. Gastrointestinal Disorders. Hematologic and Oncologic Disorders. Neurologic Disorders. Genitourinary Disorders. Pregnancy. Metabolic and Endocrine Problems. Systemic Infections. Head and Neck Problems. Immunologic and Inflammatory Disorders. Part VII: Behavioural and Societal Problems.
Different Responsiveness of Colony-forming Cells from Normal Subjects and Chronic Myeloid Leukemia Patients to 12-O-Tetradecanoylphorbol-13-acetate
Authors: Luigi Pegoraro, Gianpaolo Bagnara, Laura Bonsi, Graziella Biagini, Giovanni Garbarino, Giovanni Luca Pagliardi
Journal: Cancer Research (1981)

Abstract  The effects of 12- O -tetradecanoylphorbol-13-acetate (TPA), a potent inducer of differentiation, upon the  in vitro  proliferation of normal bone marrow and chronic myeloid leukemia granulocyte-macrophage progenitor cells were investigated in the presence or absence of exogenous colony-stimulating activity. In the absence of colony-stimulating activity, no colony formation occurred, whereas its presence was followed by the appearance of colonies almost exclusively composed of macrophagic cells. However, both normal and leukemic granulocytemacrophage progenitor cells showed a different response to TPA in terms of colony number and size. The number of colonies obtained from normal bone marrow was reduced to about 45% at three TPA concentrations (1 × 10 -8 , 1 × 10 -10 , and 1 × 10 -12 m). By contrast, the plating efficiency of leukemic granulocyte-macrophage progenitor cells was not significantly affected by 1 × 10 -10  and 1 × 10 -12 m TPA, but was strongly reduced by 1 × 10 -8 m. Moreover, TPA treatment did not significantly influence the size of colonies from normal bone marrow, while at 1 × 10 -10  and 1 × 10 -12 m, it remarkably increased that of the leukemic colonies. These different responses to TPA can be related to the abnormal sensitivity of chronic myeloid leukemia stem cells to factors regulating proliferation.
<i>Portrait of Emy</i>
Authors: M. Therese Southgate
Journal: JAMA (2003)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Journals JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Abstract 13850: Outcomes and Resource Utilization in ST Elevation Myocardial Infarction in the United States: Evidence for socioeconomic disparities
Authors: Shikhar Agarwal, Aatish Garg, Akhil Parashar, Wael A Jaber, Venu Menon
Journal: Circulation (2014)

Background: Socioeconomic status (SES) as reflected by residential zip code status may detrimentally influence a number of pre-hospital clinical, access-related and transport variables that influence outcome for patients with ST-elevation myocardial infarction (STEMI) undergoing reperfusion. We sought to analyze the relationship between SES and in-hospital mortality following STEMI. Methods: We used the 2003-2011 US Nationwide Inpatient Sample for this study. All admissions with a principal diagnosis of STEMI were identified using standard ICD codes. SES was classified based on median household income of the residential zip code of every patient. In-hospital death and timely reperfusion within day 0 of presentation were the primary outcomes for the study. Results: A total of 372984 admissions with STEMI were analyzed. There was a significantly higher mortality among the lowest SES quartile as compared to the highest quartile [OR (95% CI): 1.11(1.06-1.17)] (Fig). There was a highly significant trend indicating a progressively reduced timely reperfusion among patients from lower quartiles [OR (95% CI): 0.80 (0.74-0.88)] (Fig). In addition, there was a greater utilization of circulatory support devices and Swan Ganz catheterization among patients from higher as compared to lower quartiles (Fig). Furthermore, the mean adjusted cost of hospitalization among quartiles 2,3, and 4, as compared to quartile 1 was significantly higher by $913, $2140 and $4070 respectively. Conclusions: Patients residing in zip codes with lower SES had increased mortality and decreased timely reperfusion following STEMI as compared to patients residing in higher SES zip codes. Despite higher mortality, the utilization of circulatory support devices and Swan Ganz catheterization was paradoxically lower among patients from lower SES zip codes. In addition, cost of hospitalization of patients from higher SES quartiles was significantly higher than those from lower quartiles.
Research Yields Clues to Improving Cell Therapy for Parkinson Disease
Authors: M J Friedrich
Journal: JAMA (2002)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Investigating RhoC-GTPase’s role in the metastasis of head and neck squamous cell carcinoma
Authors: Mozaffarul Islam, Mani Sugumaran, Quintin Pan, Sofia Merajver, Theodoros Teknos
Journal: Cancer Research (2006)

Proc Amer Assoc Cancer Res, Volume 47, 2006

1815 

Introduction: In previous studies it has been shown that the expression of RhoC in head and neck squamous cell carcinoma is correlated with the clinical stage and lymph node involvement. RhoC-GTPase on a cellular level is involved with cytoskeleton rearrangement, cell motility, and the ability to migrate across membranes. We look to correlate RhoC-GTPase with the ability of squamous cell carcinoma to become more aggressive and metastatic. Methods: A preliminary sample (14) of squamous cell cancer cell lines from the University of Michigan cell bank (UMSCC) were screened by isolating RNA and using reverse transcriptase to make a cDNA library. PCR was then used with a specific RhoC primer and a gel electrophoresis was run. From the 14 original screened cell lines, four were selected. According to the RT-PCR, four cell lines were selected, two of these cell lines were the highest expresser of the RhoC gene (UM-SCC- 74B, UM-SCC-38) and the other two were the lowest expressers of RhoC (UMSCC 5PT, UMSCC 22B). Cell lysate was taken from these four cell lines and RhoC protein levels were quantified using a western blot with a polyclonal antibody for RhoC. To evaluate each cell line’s motility, the cells were allowed 20 hours on a micro bead lined plate with serum being the stimulant for motility. The area of each cell lines movement was measured. To further evaluate the metastatic properties of these four cell lines, the cells were placed on a micro-pore membrane insert with serum as a chemo-attractant on the opposite side. The cells that migrated to the opposite side of the gel in a 24-hour period were stained with immunoflorescence and counted. Results: The western blot done with the two high expressers and low expressers of RhoC showed the same correlation as the RT-PCR. The data gathered from the cell motility showed that the UM-SCC- 5PT cell line covered approximately 65% less area than the UMSCC 74B cell line. The invasion assay showed that the UMSCC 5PTcell line had approximately 82% fewer cells that migrated to the opposing side of the membrane. Conclusion: The results from the cell motility and the cell invasion assays correlate with the expression of RhoC. The highest expresser (UM-SCC- 74B) of the RhoC gene showed to be more motile than the lowest expresser (UMSCC 5PT). The 74B cell line also proved to have a better ability to migrate through a synthetic membrane. These findings support that the RhoC-GTPase is involved with the aggressiveness and metastatic qualities of head and neck squamous cell carcinoma.
FURTHER STUDIES OF THE RESPIRATION AND GLYCOLYSIS OF EXPERIMENTAL MAMMARY CANCER SLICES.
Authors: E. Douglas Rees, Amy Eversole, Rita Goldstein, Lyman Whitman
Journal: Cancer Research (1964)

The respiration of mammary cancer slices was studied in incubation media of various compositions. Both Crabtree and Pasteur effects were observed. The respiration rates in homologous serum and in 20 per cent fetal calf serum were similar to that observed in Ringer phosphate solution. Glycolytic rates were also comparable in these media. The respiration rate changed only slightly with time, but the rate of aerobic glycolysis decreased markedly, and changes in medium pH and glucose concentration could not account for this decrease.

The Qo2 values obtained for cancer slices from hormonally unmodified hosts corresponded closely to the Qo2 of mammary gland slices of similar connective tissue content. Some cancers from ovariectomized hosts had a decreased Qo2 which could not be accounted for by increased connective tissue content; in the absence of estrogen, cells of these cancers had an intrinsically lower respiration rate.
Relative Importance of the Glycoprotein Ib-Binding Domain and the RGD Sequence of von Willebrand Factor for Its Interaction With Endothelial Cells
Authors: Christelle Perrault, Hanneke Lankhof, Dominique Pidard, Danièle Kerbiriou-Nabias, Jan J. Sixma, Dominique Meyer, Dominique Baruch
Journal: Blood (1997)