tbuckley/cabot-search huggingface dataset:
Usefulness of Fractional Flow Reserve to Predict Clinical Outcome After Balloon Angioplasty
Authors: G. Jan Willem Bech, Nico H. J. Pijls, Bernard De Bruyne, Kathinka H. Peels, H. Rolf Michels, Hans J. R. M. Bonnier, Jacques J. Koolen
Journal: Circulation (1999)

After regular coronary balloon angioplasty, it would be helpful to identify those patients who have a low cardiac event rate. Coronary angiography alone is not sensitive enough for that purpose, but it has been suggested that the combination of optimal angiographic and optimal functional results indicates a low restenosis chance. Pressure-derived myocardial fractional flow reserve (FFR) is an index of the functional severity of the residual epicardial lesion and could be useful for that purpose.In 60 consecutive patients with single-vessel disease, balloon angioplasty was performed by use of a pressure instead of a regular guide wire. Both quantitative coronary angiography (QCA) and measurement of FFR were performed 15 minutes after the procedure. A successful angioplasty result, defined as a residual diameter stenosis (DS) <50%, was achieved in 58 patients. In these patients, DS and FFR, measured 15 minutes after PTCA, were analyzed in relation to clinical outcome. In those 26 patients with both optimal angiographic (residual DS by QCA </=35%) and optimal functional (FFR >/=0.90) results, event-free survival rates at 6, 12, and 24 months were 92+/-5%, 92+/-5%, and 88+/-6%, respectively, versus 72+/-8%, 69+/-8%, and 59+/-9%, respectively, in the remaining 32 patients in whom the angiographic or functional result or both were suboptimal (P=0.047, P=0.028, and P=0.014, respectively).In patients with a residual DS </=35% and FFR >/=0.90, clinical outcome up to 2 years is excellent. Therefore, there is a complementary value of coronary angiography and coronary pressure measurement in the evaluation of PTCA result.
Ampicillin for persistent typhoid excreters, including a clinical trial in convalescence.
Authors: E. M. Russell, A. Sutherland, W. Walker
Journal: BMJ (1966)

Chronic Enteric Carriers-Sharp CriBRITISH 555 optimum size for a public health department to have an infectious diseases epidemiological section, whose medical staff can devote some time and effort to the management of chronic enteric carriers.There is no doubt in my mind that a close liaison with carriers is very desirable for all concerned.This should of course be primarily the responsibility of the medical officer of health rather than the individual family doctors.The relationship should begin in hospital with all enteric cases, whether they subsequently become carriers or not.The emotional support given to potential carriers in the early months after discharge from hospital can be invaluable in establishing the relationship even in the more acutely disturbed cases where the family doctor may also be involved.In a larger study of enteric carriers in Western Germany, Rasch (1964) also con- cluded that more attention should be given to the medical and social welfare of carriers.Every carrier in group II is readily approachable at any time.In group I there are some who are either relatively unapproachable or who still resent their having been "neglected," with sporadic visits only from a sanitary inspector, with whom they were often reluctant to discuss personal problems related to their carrier state. SummaryThe personal, social, and environmental problems of the 18 chronic enteric carriers in the City of Edinburgh are described and discussed.A comparison is made of the acquired psychological disturbances of two numerically equal groups of carriers, discovered before and after an outbreak of paratyphoid B in 1963, in relation to their public-health management.Brief details are given of social, epidemiological, and clinical histories and personality types of the individual carriers.Only two carriers had not been upset at all, while one at least had acquired a decided " leper complex."Some concern is felt about the younger carriers who are unmarried women and have a greater remaining life expectancy, particularly the youngest, aged 19, who was infected soon after leaving school and has already had her life considerably disturbed.A close liaison between the public health department and individual carriers appears to have no effect in minimizing the occurrence of psychological disturbances, but there is no doubt in my mind of the desirability of such liaison for all concerned.
Genetics of osteoarthritis.
Authors: F M Cicuttini, T D Spector
Journal: Annals of the Rheumatic Diseases (1996)

The available evidence suggests that genetic factors have a major role in osteoarthritis. It has been believed for over 50 years that a strong genetic component to certain forms of osteoarthritis is present. This genetic influence has now been estimated to be up to 65% in a recent twin study. The nature of the genetic influence in osteoarthritis is speculative and may involve either a structural defect (that is, collagen), alterations in cartilage or bone metabolism, or alternatively a genetic influence on a known risk factor for osteoarthritis such as obesity. Exciting work has showed that mutations in the collagen type 2 are important in some rare, familial forms of osteoarthritis. Further work is needed on isolating the gene or genes involved in the pathogenesis of this common, disabling condition.
Cyclosporin A and tacrolimus, but not rapamycin, inhibit MHC-restricted antigen presentation pathways in dendritic cells
Authors: Young-Ran Lee, In-Ho Yang, Young-Hee Lee, Sun-A Im, Sukgil Song, Hong Li, Kun Han, Kyungjae Kim, Seong Kug Eo, Chong-Kil Lee
Journal: Blood (2005)
Injuries of the Head in Relation to Crimes of Violence
Authors: C. L. Drew
Journal: BMJ (1883)

TiHE B1'ITh#H M#bWAL TJRYAL.)fn October 26th.-i.e., when it was six days old-the skin hadd be- rNme so red and thin over the upper part of the swelling, that I saw it would bitst if left a day longer: hence I decided to 'operate at bhat early period.Mr. Win.Hall kindly gave chloroform, and, when the infant was Fully ansssthetised, I made a vertical incision
Relative size of the human corpus callosum redux: Statistical smoke and mirrors?
Authors: Ralph L. Holloway
Journal: Behavioral and Brain Sciences (1998)

Data do exist to support the fact that the corpus callosum is relatively larger in women than in men. The corpus callosum is an integral part of the brain, and contrary to Fitch &amp; Denenberg's examples of “pseudostatistics,” is not an extrinsic structure when determining its relative size.
Screening for Prostate Cancer
Authors: Alfred O. Berg
Journal: Annals of Internal Medicine (2003)

Letters16 September 2003Screening for Prostate CancerAlfred O. Berg, MD, MPHAlfred O. Berg, MD, MPHFrom U.S. Preventive Services Task Force; Rockville, MD 20852.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-139-6-200309160-00031 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail IN RESPONSE:Drs. Smith and Robertson share the common view that all prostate cancer, if left alone, will grow, spread, and kill. This is fortunately not the case. Some cancerous prostate tumors clearly grow and spread with devastating consequences, as both correspondents remind us, but most do not. The core of the difficulty is that clinicians cannot tell which is which at the time of diagnosis following a positive result on a screening test.Autopsy studies show that approximately 30% of men at age 50 years, 50% of men at age 70 years, and almost all men by age 100 ... Author, Article, and Disclosure InformationAuthors: Alfred O. Berg, MD, MPHAffiliations: From U.S. Preventive Services Task Force; Rockville, MD 20852. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoScreening for Prostate Cancer: Recommendation and RationaleScreening for Prostate Cancer: An Update of the Evidence for the U.S. Preventive Services Task Force Russell Harris and Kathleen N. Lohr Screening for Prostate Cancer Robert L. Smith Screening for Prostate Cancer H. Thomas Robertson Metrics 16 September 2003Volume 139, Issue 6Page: 532KeywordsAutopsyCancer screeningCancer treatmentProstate cancer ePublished: 16 September 2003 Issue Published: 16 September 2003 Copyright & PermissionsCopyright © 2003 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Acts of Mercy
Authors: C. Martin
Journal: BMJ (2010)

A photograph, taken in 1930, shows smiling nurses watching workmen removing a pair of paintings by Frederick Cayley Robinson (1862-1927) from Middlesex Hospital, before its demolition.⇓ In 1912 a governor and benefactor of the hospital, Edmund Davis, commissioned Cayley Robinson to paint four large pictures for the imposing entrance hall of James Paine’s 18th century building. The allegorical subjects of the series, “Acts of Mercy,” derive from Christian teachings, which include attending the sick and feeding the hungry.



The Middlesex Hospital entrance with one of the Doctor paintings from Frederick Cayley Robinson’s “Acts of Mercy” series being moved during building works, 1930

University College London Hospitals NHS Foundation Trust

Cayley Robinson’s first pair, Orphans , was completed in 1915. …
Mason and Currey's Introduction to Clinical Rheumatology
Authors: J. F. C. Schnetler
Journal: Annals of the Rheumatic Diseases (1981)

arranged logically, and is considerably enhanced by clear and attractive line drawings by W. Brennan.The reader is not plunged into a mass of detail on individual aids but asked first, Is a hoist really necessary?While few doctors will require detailed knowledge of individual hoists, slings, and accessories, most working with patients with mobility problems would find this chapter a highly readable source of information on transferring and on toileting difficulties and their solution.This information obviously derives from Miss Tarling's experience in the Disabled Living Foundation and the Newcastle Aids Centre, and indicates the value of aids centres.Such advice is not easily obtainable elsewhere.The book deals with the use of hoists in virtually every situation, in hospital, at home, at work, and in transit.It should be available in all departments of rehabilitation, to all who are concerned with the ordering of hoists, and all who must use them, in which case its use should be reinforced by practical training.
SERIAL CHANGES IN SINGLE VENTRICLE FLOWS FROM GLENN TO TOTAL CAVOPULMONARY CONNECTION: COMPARISON OF MRI TO LUMPED PARAMETER MODELING
Authors: Christopher M. Haggerty, Kartik S. Sundareswaran, Kerem Pekkan, Kirk R. Kanter, Mark A. Fogel, Ajit P. Yoganathan
Journal: Journal of the American College of Cardiology (2011)
Activated human polymorphonuclear leucocytes reduce rabbit papillary muscle function: role of the CD 18 glycoprotein adhesion complex
Authors: R. Kraemer, C W. Smith, K. M Mullane
Journal: Cardiovascular Research (1991)

Journal Article Activated human polymorphonuclear leucocytes reduce rabbit papillary muscle function: role of the CD 18 glycoprotein adhesion complex Get access Rosemary Kraemer, Rosemary Kraemer Search for other works by this author on: Oxford Academic PubMed Google Scholar C Wayne Smith, C Wayne Smith Search for other works by this author on: Oxford Academic PubMed Google Scholar Kevin M Mullane Kevin M Mullane Search for other works by this author on: Oxford Academic PubMed Google Scholar Cardiovascular Research, Volume 25, Issue 2, February 1991, Pages 172–175, https://doi.org/10.1093/cvr/25.2.172 Published: 01 February 1991 Article history Accepted: 07 December 1990 Published: 01 February 1991
The Single Nucleotide Polymorphism, CRTh2-6373G&gt;A, is Associated with Allergic Asthma and Increased Expression of CRTh2
Authors: L. Cameron, E. Campos Alberto, E. MacLean, C. Davidson, D. Brenner, A. El-Sohemy, H. Vliagoftis
Journal: Journal of Allergy and Clinical Immunology (2012)
Selective induction of monocyte and not neutrophil-attracting chemokines after influenza A virus infection.
Authors: H Sprenger, R G Meyer, A Kaufmann, D Bussfeld, E Rischkowsky, D Gemsa
Journal: The Journal of Experimental Medicine (1996)

It is characteristic for virus infections that monocytes/macrophages and lymphocytes infiltrate infected tissue while neutrophils are absent. To understand the mechanisms selectively attracting mononuclear cells in viral diseases, we examined in an influenza A virus model the expression and regulation of chemokines as candidate molecules responsible for the immigration of leukocytes into inflamed tissue. After influenza A virus infection of human monocytes, a rapid expression of the mononuclear cell attracting CC-chemokine genes MIP-1, MCP-1, and RANTES occurred which was followed by the release of chemokine proteins. In striking contrast to CC-chemokines, the expression of the prototype neutrophil CXC-chemoattractants IL-8 and GRO-alpha was completely suppressed after influenza A infection. The release of other neutrophil chemotactic factors was excluded by microchemotaxis assays. These results suggest that the virus-specific induction of mononuclear cell-attracting chemokines accounts for the preferential influx of mononuclear leukocytes into virus-infected tissue.
Would We Rather Lose Our Life Than Lose Our Self? Lessons From the Dutch Debate on Euthanasia for Patients With Dementia
Authors: Cees M. P. M. Hertogh, Marike E. de Boer, Rose-Marie Dröes, Jan A. Eefsting
Journal: The American Journal of Bioethics (2007)

This article reviews the Dutch societal debate on euthanasia/assisted suicide in dementia cases, specifically Alzheimer's disease. It discusses the ethical and practical dilemmas created by euthanasia requests in advance directives and the related inconsistencies in the Dutch legal regulations regarding euthanasia/assisted suicide. After an initial focus on euthanasia in advanced dementia, the actual debate concentrates on making euthanasia/assisted suicide possible in the very early stages of dementia. A review of the few known cases of assisted suicide of people with so-called early dementia raises the question why requests for euthanasia/assisted suicide from patients in the early stage of (late onset) Alzheimer's disease are virtually non-existent. In response to this question two explanations are offered. It is concluded that, in addition to a moral discussion on the limits of anticipatory choices, there is an urgent need to develop research into the patient's perspective with regard to medical treatment and care-giving in dementia, including end-of-life care.
Induction of the Cdk inhibitor p21 by LY83583 inhibits tumor cell proliferation in a p53-independent manner
Authors: Dimitri Lodygin, Antje Menssen, Heiko Hermeking
Journal: Journal of Clinical Investigation (2002)

Using microarray analysis, we have detected downregulation of several components of the cGMP signaling pathway during replicative senescence of primary human diploid fibroblasts (HDFs). Therefore, the effect of pharmacological inhibition of cGMP synthesis was analyzed in HDFs. Treatment with 6-anilino-5,8-quinolinequinone (LY83583, referred to as LY hereafter), a previously described inhibitor of guanylate cyclase, induced cellular senescence. Microarray analysis revealed that LY treatment induced the Cdk inhibitor p21WAF1/SDI/CIP1. In colorectal cancer cells, transcription of p21 was induced by LY in a p53-independent manner. Furthermore, p21, but not p53, was required for inhibition of proliferation by LY. The lack of p53 involvement suggests that LY does not induce DNA damage. Growth inhibition was also observed in malignant melanoma and breast cancer cell lines. Functional inactivation of the retinoblastoma tumor-suppressor protein, an effector of p21-mediated cell-cycle inhibition, converted LY-induced growth arrest to apoptosis. These results suggest that LY, or derivatives, may be useful therapeutic agents for the treatment of tumors.
The Electrocardiology of Coronary Artery Disease
Authors: David L. Abrams
Journal: JAMA (1985)

It is always gratifying to review a well-organized, concise, and clearly written book; this is precisely what Dr Schamroth has produced in the second edition of his comprehensive, abundantly illustrated text dealing with the electrocardiography of coronary disease. The book is divided into two parts, which are separately indexed. Part 1 is the text itself, consisting of four sections covering basic principles, myocardial infarction, coronary insufficiency, and abnormal rhythms associated with acute myocardial infarction. All chapters in part 1, with the exception of those in the section on basic principles, include correlative essays that are brief dissertations on the differential diagnosis of aspects of the subject presented in that chapter. The second part of the book consists of electrocardiograms illustrating specific aspects of topics covered in the text. Each electrocardiogram is accompanied by a description of its salient features. In addition, there is an extensive reference section. There is a
TCT-393 Different Efficacy Between Everolimus- versus Sirolimus-Eluting Stents in Complex Bifurcation Intervention like Left Main Lesions or Two Stent Technique (Korean Multi-center Registry for Coronary Bifurcation Stenting)
Authors: Youngjin Cho, Min-Ho Lee, Bon-Kwon Koo, Si-Hyuck Kang, Seung-Hyuk Choi, Jin-Ho Choi, Hyeon-Cheol Gwon, Joo-Yong Hahn, Kyung Woo Park, Young Bin Song, Hyo-Soo Kim
Journal: Journal of the American College of Cardiology (2013)
TREATMENT OF ACTINOMYCOSIS AND BLASTOMYCOSIS WITH COPPER SALTS.
Authors: ARTHUR DEAN BEVAN
Journal: JAMA (1905)

I desire to make a very brief preliminary report on the subject of the treatment of cases of actinomycosis and incidentally blastomycosis with copper salts. I do this at this time because I believe that, on account of the rather limited number of cases of actinomycosis and blastomycosis that come to one man, collective statistics of a trial of this method of treatment will do more to give us early definite and positive knowledge of its value than can be obtained by limiting it simply to the treatment of the few cases that come to my service. Last year we had a half dozen cases of actinomycosis in my service, and since that time, at the Presbyterian Hospital, there have been a number of others, both in my service and in the service of Dr Billings and other attending men. We have found, as others have, in connection with the
Genetic susceptibility to hypertension-induced renal damage in the rat. Evidence based on kidney-specific genome transfer.
Authors: P C Churchill, M C Churchill, A K Bidani, K A Griffin, M Picken, M Pravenec, V Kren, E St Lezin, J M Wang, N Wang, T W Kurtz
Journal: Journal of Clinical Investigation (1997)

To test the hypothesis that genetic factors can determine susceptibility to hypertension-induced renal damage, we derived an experimental animal model in which two genetically different yet histocompatible kidneys are chronically and simultaneously exposed to the same blood pressure profile and metabolic environment within the same host. Kidneys from normotensive Brown Norway rats were transplanted into unilaterally nephrectomized spontaneously hypertensive rats (SHR-RT1.N strain) that harbor the major histocompatibility complex of the Brown Norway strain. 25 d after the induction of severe hypertension with deoxycorticosterone acetate and salt, proteinuria, impaired glomerular filtration rate, and extensive vascular and glomerular injury were observed in the Brown Norway donor kidneys, but not in the SHR-RT1.N kidneys. Control experiments demonstrated that the strain differences in kidney damage could not be attributed to effects of transplantation-induced renal injury, immunologic rejection phenomena, or preexisting strain differences in blood pressure. These studies (a) demonstrate that the kidney of the normotensive Brown Norway rat is inherently much more susceptible to hypertension-induced damage than is the kidney of the spontaneously hypertensive rat, and (b) establish the feasibility of using organ-specific genome transplants to map genes expressed in the kidney that determine susceptibility to hypertension-induced renal injury in the rat.
STUDIES ON THE NATURE OF THE VIRUS OF INFLUENZA
Authors: Leslie A. Chambers, Werner Henle, Max A. Lauffer, Thomas F. Anderson
Journal: The Journal of Experimental Medicine (1943)

The pathogenic agent of influenza A has been sedimented from infected extra-embryonic fluids of the developing chick, embryo by ultracentrifugation. Material so obtained contains two fractions resolvable in the analytical centrifuge cell. The first, a homogeneous fraction, showed a sedimentation constant S(20) = 20 to 31 x 10(-13). The second showed a sedimentation constant S(20) = about 800 +/- 100 x 10(-13), was much less homogeneous than the first, and was shown to consist principally of aggregated particles of the more disperse fraction. Both fractions contained the virus in essentially equal amounts per unit of protein weight as calculated from nitrogen determinations. Electron micrographs of the isolated virus protein indicated that the predominating unit is roughly spherical in shape and has a modal particle diameter of about 11 mmicro, in good agreement with the sedimentation data in indicating a molecular weight of about 650,000. Approximately 300 of the particles having molecular weight of 650,000 were present in the minimal dose producing infection in mice after nasal instillation. The influenza A virus may now be regarded as one of the smallest pathogenic agents thus far isolated. Preliminary analyses indicate that it is also one of the least complex, being composed principally of nucleoprotein.
Too Many Words? Mozart 1, Emperor 0-Reply
Authors: Robert Fletcher
Journal: JAMA (1995)

<h3>In Reply.</h3> —We agree with Dr Goodman and accept his criticism of our article. In response to his question, we believe that responsibility rests mainly with the editors. We believe that editors are teachers for authors, and that editors would do well to spend extra time working with authors whose manuscripts contain flaws in design, methodology, or expression. However, the senior editors are already fully occupied with the work they do to select manuscripts and improve their scientific accuracy and completeness. Manuscripts could be rewritten best by additional people with mastery of both written expression and clinical science. Do additional resources exist to sustain such people? Perhaps the problem rests more fundamentally with medical educators. How many universities or medical centers have writing coaches or experts (not ghostwriters) who help teach young and inexperienced authors how to express themselves clearly and concisely?
Comparative single-institute analysis of cord blood transplantation from unrelated donors with bone marrow or peripheral blood stem-cell transplants from related donors in adult patients with hematologic malignancies after myeloablative conditioning regimen
Authors: Satoshi Takahashi, Jun Ooi, Akira Tomonari, Takaaki Konuma, Nobuhiro Tsukada, Maki Oiwa-Monna, Kenji Fukuno, Michihiro Uchiyama, Kashiya Takasugi, Tohru Iseki, Arinobu Tojo, Takuhiro Yamaguchi, Shigetaka Asano
Journal: Blood (2006)
Keap1-null mutation leads to postnatal lethality due to constitutive Nrf2 activation
Authors: Nobunao Wakabayashi, Ken Itoh, Junko Wakabayashi, Hozumi Motohashi, Shuhei Noda, Satoru Takahashi, Sumihisa Imakado, Tomoe Kotsuji, Fujio Otsuka, Dennis R Roop, Takanori Harada, James Douglas Engel, Masayuki Yamamoto
Journal: Nature Genetics (2003)
Breast conservation in mammary carcinoma
Authors: M. Webster
Journal: BMJ (1977)

Respiratory side effects of beta-blockers SIR,-I would like to comment on one aspect of the hazards of beta-blockers (leading article, 26 February, p 529)-namely, their use in patients with airways obstruction.It is well known that blockade of beta2 receptors may lead to bronchoconstriction in asthmatics.'This risk is said to be less with the so-called selective beta-blockers, which block predominantely the beta, receptors.My