tbuckley/cabot-search huggingface dataset:
Associations Between Selected Xenobiotics and Antinuclear Antibodies in the National Health and Nutrition Examination Survey, 1999–2004
Authors: Gregg E. Dinse, Todd A. Jusko, Irene Z. Whitt, Caroll A. Co, Christine G. Parks, Minoru Satoh, Edward K.L. Chan, Kathryn M. Rose, Nigel J. Walker, Linda S. Birnbaum, Darryl C. Zeldin, Clarice R. Weinberg, Frederick W. Miller
Journal: Environmental Health Perspectives (2015)

Background:Potential associations between background environmental chemical exposures and autoimmunity are understudied.Objectives:Our exploratory study investigated exposure to individual environmental chemicals and selected mixtures in relation to the presence of antinuclear antibodies (ANA), a widely used biomarker of autoimmunity, in a representative sample of the U.S. population.Methods:This cross-sectional analysis used data on 4,340 participants from the National Health and Nutrition Examination Survey (1999–2004), of whom 14% were ANA positive, to explore associations between ANA and concentrations of dioxins, dibenzofurans, polychlorinated biphenyls, organochlorines, organophosphates, phenols, metals, and other environmental exposures and metabolites measured in participants' serum, whole blood, or urine. For dioxin-like compounds with toxic equivalency factors, we developed and applied a new statistical approach to study selected mixtures. Lognormal models and censored-data methods produced estimates of chemical associations with ANA in males, nulliparous females, and parous females; these estimates were adjusted for confounders and accommodated concentrations below detectable levels.Results:Several associations between chemical concentration and ANA positivity were observed, but only the association in males exposed to triclosan remained statistically significant after correcting for multiple comparisons (mean concentration ratio = 2.8; 95% CI: 1.8, 4.5; p < 0.00001).Conclusions:These data suggest that background levels of most xenobiotic exposures typical in the U.S. population are not strongly associated with ANA. Future studies should ideally reduce exposure misclassification by including prospective measurement of the chemicals of concern and should track changes in ANA and other autoantibodies over time.Citation:Dinse GE, Jusko TA, Whitt IZ, Co CA, Parks CG, Satoh M, Chan EKL, Rose KM, Walker NJ, Birnbaum LS, Zeldin DC, Weinberg CR, Miller FW. 2016. Associations between selected xenobiotics and antinuclear antibodies in the National Health and Nutrition Examination Survey, 1999–2004. Environ Health Perspect 124:426–436; http://dx.doi.org/10.1289/ehp.1409345
Human Immunoglobulin A Receptor (FcRI, CD89) Function in Transgenic Mice Requires Both FcR γ Chain and CR3 (CD11b/CD18)
Authors: Marjolein van Egmond, A.J. Hanneke van Vuuren, H. Craig Morton, Annemiek B. van Spriel, Li Shen, Frans M.A. Hofhuis, Takashi Saito, Tanya N. Mayadas, J. Sjef Verbeek, Jan G.J. van de Winkel
Journal: Blood (1999)
Outcomes in Mitral Regurgitation Due to Flail Leaflets
Authors: Francesco Grigioni, Christophe Tribouilloy, Jean Francois Avierinos, Andrea Barbieri, Marinella Ferlito, Faouzi Trojette, Laurence Tafanelli, Angelo Branzi, Catherine Szymanski, Gilbert Habib, Maria G. Modena, Maurice Enriquez-Sarano
Journal: JACC. Cardiovascular imaging (2008)
Functional Aphonia
Authors: Johann Kinzl, Wilfried Biebl, Hermann Rauchegger
Journal: Psychotherapy and Psychosomatics (1988)

Aphonia is the extreme form of a functional voice disorder. 22 female patients with aphonia underwent laryngoscopic and phonic examinations, psychiatric evaluation, psychological testing and biographical history-taking. Results demonstrate a homogeneous clinical picture, but heterogeneous personality structures and conflict situations. All patients are overtaxed by their situation; the conversion reaction is used as a means to express anxiety and maintain self-assertion at the same time.
Abstract 3288: Mitofusin 2 Inhibits Cardiac Fibroblast Proliferation and Collagen Synthesis Stimulated by Angiotensin II in Rat
Authors: Haiyi Yu, Yanhong Guo, Lei Li, Bing Shi, Yanlong Bai, Lin Mi, Wei Gao
Journal: Circulation (2009)

Objective: Pathological cardiac hypertrophy/remodeling is always associated with abnormal growth of cardiac fibroblasts and collagen synthesis, progressing to heart failure. Mitofusin 2(Mfn2), whic...
Abstract 9004: Creatine Kinase Over-Expression Improves ATP Kinetics and Contractile Function in the Post-Ischemic Myocardium
Authors: Ashwin Akki, Jason Su, Ashish Gupta, Vadappuram Chacko, Yibin Wang, Charles Steenbergen, Robert G Weiss
Journal: Circulation (2011)

ATP is the biochemical fuel for myocardial contraction but it is depleted during prolonged ischemia and its depletion may limit post-ischemic mechanical function. Because it has been difficult to augment ATP synthesis during and after ischemia, we generated mice that overexpress the myofibrillar isoform of Creatine Kinase (CKM), the primary energy reserve reaction of the heart, in cardiac-specific, conditional fashion to test the hypothesis that enhanced CKM expression increases ATP delivery via Creatine Kinase (CK) in ischemic-reperfused hearts and improves functional recovery. CKM mice were generated using a tet-off system. Gene induction was achieved by switching from a doxycycline diet (650mg/kg diet) to regular diet 4 weeks prior to the study. Isolated, retrograde-perfused hearts from control and CKM mice were subjected to 25 minutes of global ischemia and 40 minutes of reperfusion while cardiac function (rate pressure product, RPP) was monitored using a left ventricular balloon connected to a pressure transducer. A combination of 31P nuclear magnetic resonance magnetization transfer experiments at 11.7T and biochemical assays were used to measure the CK pseudo first-order rate constant (kf), the rate of ATP synthesis via CK (CK flux), intracellular pH and in vitro CK activity. Pre-ischemic kf and CK flux were three-fold higher in CKM than control hearts with no difference in RPP (Table). During ischemia, intracellular pH fell more in control than CKM hearts (6.10±0.29 vs. 6.46±0.08, p&lt;0.05) with no difference in PCr and ATP levels between the two groups. Post-ischemic kf, PCr, CK flux and functional recovery were significantly higher in CKM vs. control hearts as was CK activity (21.6±7.23 vs 7.59±1.42 IU/mg protein, p&lt;0.01). These observations demonstrate that augmenting CKM expression attenuates ischemic acidosis and improves not only [PCr] and rate of ATP synthesis in the post-ischemic myocardium but also recovery of contractile function.
Abstract 16533: Exercise Training Normalizes Renal Blood Flow Responses to Acute Hypoxia and Exercise in Experimental Heart Failure
Authors: Carolin Pugge, Pamela L Curry, Sarah C Clayton, Noah J Marcus, Harold D Schultz, Irving H Zucker
Journal: Circulation (2011)

Chronic heart failure (CHF) is often accompanied by a decrease in renal function. The mechanisms of the cardio-renal syndrome are unclear. Exercise training (ExT) has been shown to be a non-pharmac...
Abstract 3156: Prevalence of Unrecognized and Recognized Myocardial Infarction in Older Individuals with Elevated NT-pro-BNP
Authors: Erik Schelbert, Jie J Cao, Peter Kellman, Anthony H Aletras, Sigurdur Sigurdsson, Thor Aspelund, Gudny Eiriksdottir, Lenore J Launer, Tamara B Harris, Vilmundur Gudnason, Andrew E Arai
Journal: Circulation (2008)
Undiagnosed vomiting in an older woman: unsuspected bulimia
Authors: J M Jonas, H G Pope, J I Hudson, A Satlin
Journal: American Journal of Psychiatry (1984)

Bulimia, believed to occur primarily in young women, is rarely suspected in older individuals. The authors report on a 56-year-old woman with rapid cycling bipolar disorder, whose unexplained vomiting proved attributable to bulimia.
Association of prescribed Chinese herbal medicine use with risk of end-stage renal disease in patients with chronic kidney disease
Authors: Ming-Yen Lin, Yi-Wen Chiu, Jung-San Chang, Hung-Lung Lin, Charles Tzu-Chi Lee, Guei-Fen Chiu, Mei-Chuan Kuo, Ming-Tsang Wu, Hung-Chun Chen, Shang-Jyh Hwang
Journal: Kidney International (2015)
Suicide in patients with stroke
Authors: K R Brittain, C M Castleden, R. Rao
Journal: BMJ (1998)

Further studies of heroin treatment are neededEditor-On the basis of a trial in Switzerland, 1 Farrell and Hall conclude that medically prescribed heroin is likely to have only a limited role in the future. 2 It is hard to know how any judgment can be made about this approach after only one randomised control trial, 3 one case-control study, 4 and the large but uncontrolled study that the authors commented on. 1 Farrell and Hall are right to emphasise the difficulty of disentangling the contribution of comprehensive social and psychological inventions in the impressive results obtained in this population. 1After more than three decades of research evaluating the effectiveness of methadone maintenance treatment it is safe to conclude that such interventions improve outcomes but difficult to be much more precise than this.Social and psychological interventions probably improve results of virtually all interactions between patients and the healthcare system.The authors say that the proposal to conduct a heroin trial in Australia damaged support for harm reduction.This is arguable.The mood in Australia has generally been more conservative over the past two years.The controversy over the heroin trial in Australia probably contributed to major improvements in a local methadone programme and certainly led directly to a commitment and funding for research on an expanded range of pharmacological treatments for heroin dependence.The authors question whether Australia is in the middle of a national heroin crisis.If a sixfold increase in mortality from drug overdose during the past 16 years 5 is not a crisis it is hard to know what would be.The Swiss heroin trial may have been more expensive than routine prescription methadone.But trials of new treatment are invariably more costly than providing well established treatments as a routine.Heroin
Randomized phase II study of gefitinib versus erlotinib in patients with advanced non-small cell lung cancer who failed previous chemotherapy.
Authors: J. Ahn, S. Kim, M. Ahn, J. Lee, J. Uhm, J. Sun, K. Park, Y. Park
Journal: Journal of Clinical Oncology (2010)

7551 Background: Gefitinib and erlotinib are potent inhibitors of the epidermal growth factor receptor tyrosine kinase (EGFR TK), with single agent antitumor activity. In this randomized, single-center, phase II trial, the efficacy and safety of gefitinib was compared with that of erlotinib as the second-line therapy for advanced non-small cell lung cancer patients. Methods: Patients with locally or metastatic stage IIIB or IV non-small cell lung cancer (NSCLC), after failure of first line chemotherapy, were to assigned to gefitinib 250 mg or erlotinib 150 mg orally daily until disease progression or development of intolerable toxicity. The primary end point was response. Secondary end points were progression free survival (PFS), overall survival (OS), quality of life (QOL), toxicity profile, and a molecular correlation. Results: A total of 96 patients were enrolled between August 2007 and October 2008. Each forty-eight patients were randomly assigned to gefitinib and erlotinib arm, equally. Baseline demographic and disease characteristics were well balanced. The overall response rates (ORR) was 47.9% (95% CI, 33.8-62.0) in the gefitinib arm and 39.6% (95% CI, 25.7-53.4) in the erlotinib arm (p = 0.411). Median PFS was 4.9 months in the gefitinib arm and 3.1 months in the erlotinib arm (hazard ratio [HR] = 0.81; 95% CI, 0.52-1.25; p = 0.336). The most common grade 3/4 adverse event was skin rash. Although more patients in the erlotinib arm showed grade 3/4 skin rash, patients requiring dose reduction of each was similar. QOL was similar between the two arms. The ORR for patients with EGFR mutation was better than those for patients with EGFR wild type (p = 0.001). Conclusions: There was no statistically significant difference in ORR, PFS, after treatment with gefitinib or erlotinib. Improvements in QOL and tolerability for treatment were similar in both groups. No significant financial relationships to disclose.
Abstract 18723: Socioeconomic Disparities and Burden of Sudden Cardiac Arrest in Metropolitan Areas: A USA-Canada Comparative Analysis
Authors: Kyndaron Reinier, Elizabeth Thomas, Douglas L Andrusiek, Tom P Aufderheide, Steven C Brooks, Thomas D Rea, Clifton Callaway, Paul E Pepe, Robert H Schmicker, Christian Vaillancourt, Sumeet S Chugh
Journal: Circulation (2010)

Introduction:  Low socioeconomic status (SES) is associated with poor cardiovascular outcomes and may be a determinant of sudden cardiac arrest (SCA) incidence.   Objective:  We evaluated the association between SES and SCA incidence from seven sites in the Resuscitation Outcomes Consortium (ROC) Epistry, a registry of all out-of-hospital cardiac arrests assessed by emergency medical services personnel, and tested whether the relationship differed between the US and Canada.   Methods:  Cases were primary cardiac arrests occurring in a residence in Dallas, Pittsburgh, Portland, and Seattle-King County ROC sites (US); and Ottawa, Toronto, and Vancouver sites (Canada), 4/1/2006 - 3/31/2007. Each case was linked to the census tract in which the arrest occurred. Census tracts were classified into quartiles of median income, and incidence per quartile was calculated using all SCAs occurring in census tracts in that quartile (numerator), and the population of all census tracts in that quartile (denominator). Poisson regression was used to estimate and compare SCA incidence rate ratios (IRRs) in the lowest vs. highest quartile of SES.   Results:  Across the 9,235 total SCAs (range 638-2,586 per site; mean ages 64-70 years; males 58-65%), incidence was nearly double in the lowest vs. highest SES quartile (IRR 1.9 [95% CI 1.8-2.0]). This disparity was stronger in those    Conclusions:  SCA incidence was consistently higher in poorer neighborhoods of North American metropolitan areas, though this relationship was attenuated in Canadian cities. These findings underscore the important association of SES with SCA incidence, also suggesting that fundamental differences between the two countries may contribute to the greater adverse impact of SES in the US.
Abstract 3525: Targeting Risk Factors To Goals Is Associated With Better Outcomes Among Patients With Coronary Artery Bypass Surgery: Insights From the REACH Registry
Authors: Rajendra H Mehta, Deepak Bhatt, Gabriel Steg, Chiau-Suong Liau, Kim A Eagle, Shinya Goto, Peter W Wilson, E. Magnus Ohman
Journal: Circulation (2007)

Background: The relationship of achieving secondary prevention target treatment goals for cardiovascular risk factors with clinical outcomes in patients (pts) with prior coronary artery bypass surg...
Northern ℞posure
Authors: Rebecca Voelker
Journal: JAMA (2003)

ANN ARBOR, MICH—Mounting concerns that US consumers’ appetite for low-cost prescription medications from Canadian Internet pharmacies will erode their northern neighbors’ public health could extinguish such cross-border distribution schemes, say some experts from north of the border. Recently, Canadians have faced reports of medication shortages and notices of price increases, despite their country’s system of price controls on patented medications. Experts say the monetary lure of Internet pharmacies entices pharmacists to trade face-toface patient contact for a desk and a fax machine. Some even speculate that the growing cross-border trade could lead to the dismantling of Canada’s pricesetting regulatory agency. During a mid-November meeting in Ottawa, Ontario, US and Canadian health officials agreed to share information on prescription drugs and collaborate on safety measures, even though US Food and Drug Adminstration Commissioner Mark McClellan, MD, PhD, had sought a stronger stance from Canada to restrict Internet medication exports to the United States. But just a few weeks earlier, during a conference here on pharmaceutical reimportation, experts from north of the border said that Canada eventually may step in to halt the practice. “Ultimately, I think . . . you are going to see legislative initiatives coming out of Canada that will close the doors to this kind of practice, if not at the provincial level, then certainly at the national level,” said Chris Ward, a former Ontario legislator who now heads Ward Health Strategies Inc, a health care consulting firm with offices in Ontario and New Jersey. “To date, [government policy] has been rather reserved, and now there’s definitely a change in climate in Canada,” added Jillian Clare Cohen, PhD, assistant professor in the Leslie
Lenalidomide and stem cell collection in patients with multiple myeloma
Authors: R. J. Cook, D. Vogl, P. A. Mangan, K. Cunningham, S. Luger, D. L. Porter, D. E. Tsai, M. Raguza-Lopez, K. Wiley, K. Masters, E. A. Stadtmauer
Journal: Journal of Clinical Oncology (2008)

8547 Background: Lenalidomide is an active agent for intial treatment of multiple myeloma. Autologous stem cell transplant (ASCT) as part of first line therapy has been shown to prolong survival. Marrow suppression from lenalidomide may reduce the ability to adequately collect stem cells for ASCT. Recent reports have suggested that (1) the number of CD34+ cells collected is reduced, (2) the number of collections to obtain a target number of cells increased, and (3) the number of failed collections is increased in pts whose initial therapy contained lenalidomide when mobilized with G-CSF alone. We report here our experience with stem cell collection when comparable pts were mobilized primarily with G-CSF and cyclophosphamide (CYT). Methods: Pts were eligible for analysis if they had a diagnosis of myeloma, an initial treatment regimen was documented, and underwent stem cell mobilization and harvest at Penn between 2004 and 2007. Of 158 pts, 21 had a lenalidomide-containing induction regimen. For initial mobilization of these pts, 17 received CYT (16 at 3g/m2, 1 at 4.5 g/m2) and G-CSF 10 ug/kg, 2 received GCSF alone (10 ug/kg) and required salvage G-CSF and AMD3100, and 2 received G-CSF (10 ug/kg) and AMD3100. Results: Adequate numbers of CD34+cells x 10^6/kg (CD34 cells) to proceed with ASCT were collected on all pts in the lenalidomide group (median 6.3, range 2.4–19.7). 2/21 pts required repeat mobilization (both pts who received G-CSF alone) and were mobilized successfully on the second attempt with AMD3100. Median # of collections and CD34 cells and range were: G-CSF/CYT mobilization 3 (1–8) and 6.3 (3.0–19.7); G-CSF alone both failed to collect; G-CSF/AMD mobilization 4.5 (2–6) and 8.4 (5.6–12.3). The median # of cycles of lenalidomide induction therapy was 4 (1–16) and did not influence the # of collections or total CD34 cell counts. We also analyzed 137 pts who received non- lenalidomide containing induction therapy. 2 pts did not collect adequately. Among the remaining 135 pts, 3 pts required repeat mobilization. Median # of collections was 2.0 (1–11) with 7.3 (2.4–72.5) CD34 cellls collected. Conclusions: Initial therapy with lenalidomide does not prevent harvest of adequate numbers of CD34 cells for ASCT, but mobilization with G-CSF alone may be inferior to combination therapy such as G-CSF and CYT. Author Disclosure Employment or Leadership Consultant or Advisory Role Stock Ownership Honoraria Research Expert Testimony Other Remuneration Celgene
The prognostic landscape of genes and infiltrating immune cells across human cancers
Authors: Andrew J Gentles, Aaron M Newman, Chih Long Liu, Scott V Bratman, Weiguo Feng, Dongkyoon Kim, Viswam S Nair, Yue Xu, Amanda Khuong, Chuong D Hoang, Maximilian Diehn, Robert B West, Sylvia K Plevritis, Ash A Alizadeh
Journal: Nature Medicine (2015)
Echocardiographic predictors of morbidity and mortality in patients with advanced heart failure
Authors: Paul A. Grayburn, Christopher P. Appleton, Anthony N. DeMaria, Barry Greenberg, Brian Lowes, Jae Oh, Jonathan F. Plehn, Peter Rahko, Martin St. John Sutton, Eric J. Eichhorn
Journal: Journal of the American College of Cardiology (2005)
Evaluation of Apaf-1 and procaspases-2, -3, -7, -8, and -9 as potential prognostic markers in acute leukemia
Authors: Phyllis A. Svingen, Judith E. Karp, Stan Krajewski, Peter W. Mesner, Steven D. Gore, Philip J. Burke, John C. Reed, Yuri A. Lazebnik, Scott H. Kaufmann
Journal: Blood (2000)
A Renal Failure Diet Manual Utilizing The Food Exchange System.
Authors: M. E. Spitzer, B. B. Dickinson, P. W. Rogers
Journal: Annals of Internal Medicine (1977)

This book is not a comprehensive survey of the field defined by its title, but rather a collection of nine separate, authoritative and, in general, well- written reviews of parts of that field, by different authors from various countries.There is con- sequently some overlap -for example, between consecutive chapters on oxygen-labile toxins, on microbial phospholipases and on alterations ofcell membranes by bacterial toxins -but with the com- pensation that each chapter is selfcontained.Much valuable information is provided for all interested in bacterial pathogenicity, in immunization, in toxins as tools for the study of host-cell mechan- isms or even in the use of bacterial toxins for treat- ment of cancer.
Abstract 19878: Metalloproteinase PAPP-A and Outcomes in Patients with ACS: Observations from the MERLIN-TIMI 36 Trial
Authors: Marc P Bonaca, Bejamin M Scirica, Marc S Sabatine, Petr Jarolim, Sabina A Murphy, Janna S Chamberlin, Daniel W Rhodes, Paula C Southwick, Eugene Braunwald, David A Morrow
Journal: Circulation (2010)

Background: Pregnancy associated plasma protein-A (PAPP-A) is a high molecular weight, zinc-binding metalloproteinase. Initial studies have suggested that PAPP-A is associated with vulnerable coron...