The Familial Occurrence of Primary Pulmonary Hypertension
Authors: JAMES D. ROGGE
Journal: Annals of Internal Medicine (1966)

Article1 October 1966The Familial Occurrence of Primary Pulmonary HypertensionJAMES D. ROGGE, MARVIN E. MISHKIN, PASQUALE D. GENOVESE, M.D., F.A.C.P.JAMES D. ROGGESearch for more papers by this author, MARVIN E. MISHKINSearch for more papers by this author, PASQUALE D. GENOVESE, M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-65-4-672 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptPrimary pulmonary hypertension is a disease characterized by increased arterial pressure in the pulmonary circulation caused by changes which appear to be intrinsic to the pulmonary vasculature. The pathology of these changes has been described for some time and has been discussed by several authors (1-5). Although many theories about the cause of these changes have been proposed, none have been proved. Because of this lack of a proved pathogenic mechanism, some authors (6-8) have used the term "idiopathic," instead of primary pulmonary hypertension.The clinical features of the disease have been so well described that some people feel the...References1. BRENNER O: Pathology of the vessels of the pulmonary circulation: Part II. Arch. Intern. Med. (Chicago) 56: 976, 1935. CrossrefGoogle Scholar2. EVANSSHORTBEDFORD WDSDE: Solitary pulmonary hypertension. Brit. Heart J. 19: 93, 1957. CrossrefMedlineGoogle Scholar3. WAGENVOORTHEATHEDWARDS CADJE: The Pathology of the Pulmonary Vasculature. Charles C Thomas, Publisher, Springfield, Ill., 1964, p. 172. Google Scholar4. HEATHEDWARDS DJE: Configuration of elastic tissue of pulmonary trunk in idiopathic pulmonary hypertension. Circulation 21: 59, 1960. CrossrefMedlineGoogle Scholar5. ROBERTS WC: The histologic structure of the pulmonary trunk in patients with "primary" pulmonary hypertension. Amer. Heart J. 65: 230, 1963. 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MedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: From the Medical Service, Veterans Administration Hospital, and the Department of Medicine, Indiana University School of Medicine, Indianapolis, Ind.This work was supported in part with facilities provided by grant HE 06308, National Heart Institute, U. S. Public Health Service Postgraduate Research Training grant HTS-5363, National Heart Institute, and the Indiana Heart Association.Dr. Mishkin performed this work during his tenure as a U. S. Public Health Service Fellow.Requests for reprints should be addressed to Pasquale D. Genovese, M.D., Veterans Administration Hospital, 1481 W. 10th St., Indianapolis, Ind. 46207. 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