tbuckley/cabot-search huggingface dataset:
Connective tissue growth factor and cardiac diastolic dysfunction: human data from the <scp>T</scp>aiwan <scp>D</scp>iastolic <scp>H</scp>eart <scp>F</scp>ailure <scp>R</scp>egistry and molecular basis by cellular and animal models
Authors: Cho‐Kai Wu, Yi‐Chih Wang, Jen‐Kuang Lee, Sheng‐Nan Chang, Mao‐Yuan Su, Huei‐Ming Yeh, Ming‐Jai Su, Jin‐Jer Chen, Fu‐Tien Chiang, Juey‐Jen Hwang, Jiunn‐Lee Lin, Chia‐Ti Tsai
Journal: European Journal of Heart Failure (2013)
Intramedullary apoptosis of hematopoietic cells in myelodysplastic syndrome patients can be massive: apoptotic cells recovered from high-density fraction of bone marrow aspirates
Authors: Vilasini Shetty, Seema Hussaini, LaTanya Broady-Robinson, Krishnan Allampallam, Suneel Mundle, Raphael Borok, Eileen Broderick, Lucia Mazzoran, Francesca Zorat, Azra Raza
Journal: Blood (2000)
Vaccination coverage among adolescents 1 year before the institution of a seventh grade school entry vaccination requirement - San Diego, California, 1998.
Authors: S. W. Klish, W. Wang, L. Linton, S. Ross, N. Fink, C. Edwards, K. M. Peddecord, N. Smith, A. Deladisma
Journal: MMWR Morbidity and Mortality Weekly Report (2000)
Clinical trials update: highlights of the scientific sessions of the American Heart Association year 2000: Val HeFT, COPERNICUS, MERIT, CIBIS‐II, BEST, AMIOVIRT, V‐MAC, BREATHE, HEAT, MIRACL, FLORIDA, VIVA and the first human cardiac skeletal muscle myoblast transfer for heart failure
Authors: Simon D.R. Thackray, Klaus K.A. Witte, Aleem Khand, Anita Dunn, Andrew L. Clark, John G.F. Cleland
Journal: European Journal of Heart Failure (2001)
The phenomenological and conceptual interface between borderline personality disorder and PTSD
Authors: J G Gunderson, A N Sabo
Journal: American Journal of Psychiatry (1993)

The authors explore the conceptual and phenomenological interface between posttraumatic stress disorder (PTSD) and borderline personality disorder as well as the therapeutic and research implications of this interface.They systematically review the relevant empirical, conceptual, and clinical literature.These seemingly separate disorders are related. Borderline personality disorder is often shaped in part by trauma, and individuals with borderline disorder are therefore vulnerable to developing PTSD.The authors draw a distinction between the enduring effects that traumas can have on formation (or change) of axis II personality traits (including those found in borderline personality disorder) and acute symptomatic reactions to trauma, called PTSD, that are accompanied by specific psychophysiological correlates. They describe the implications of these conclusions for DSM-IV, therapy, and future research.
Hepatitis C Virus
Authors: Monto Ho
Journal: New England Journal of Medicine (1991)

Pereira et al.1 report in this issue of the Journal on the high morbidity associated with the transplantation of organs from 13 cadaver donors who were positive for antibodies against the hepatitis C virus (HCV). This study of 716 donors from the New England Organ Bank shows what valuable information may be obtained by storing relevant serum samples from donors and recipients of transplants at a time when we are still learning about viruses and other microbial agents transmitted by body fluids, tissues, and organs, and the diseases they may cause.2 Non-A, non-B hepatitis developed in 48 percent of the . . .
High efficacy of recombinant urate oxidase in prevention of renal failure related to tumor lysis syndrome (TLS).
Authors: F Lascombes, D Sommelet, F Gebhard, G. Leverger, R Schaison, R. Pinkerton, André Bosly, C. Patte, J Boos, B Smedmyr, P. Lederlin, P. Stryckmans
Journal: Blood (1998)
Abstract 3656: An Intra-ventricular Device as a Potential Mechanical Solution for Diastolic Heart Failure
Authors: Shemy Carasso, Rona Shofti, Amir Sherman, Lea Lak, Michal Shmilovich, Gideon Meyer-Brodnitz, Michal Lipperman, Lior Rosen, Amir Elami
Journal: Circulation (2009)

Introduction: Diastolic heart failure (DHF) accounts for over 40% of HF cases, resulting in significant mortality and morbidity. Treatment is empirical and disappointing. Currently, no device therapy for this mechanical disorder is available. Storage of left ventricular (LV) systolic energy in a spring-device releasing it in diastole may improve diastolic function Methods: A tripod-like elastic spring device leaning on the LV endocardial surface, from the apex to the papillary muscles level was trans-apically implanted in beating sheep hearts. Safety was assessed in 6 healthy animals followed for up to 6 months after implantation. Efficacy was assessed in 4 animals with LV hypertrophy and diastolic dysfunction, induced by bilateral renal wrapping causing severe hypertension (2 had device implantation, 2 controls had sham procedure). Echocardiography was used to assess hypertrophy and diastolic function. 2D echocardiographic circumferential strain, strain-rate, rotation and reverse rotation were measured. ...
Abstract 17919: Defibrillation Thresholds in Single Versus Dual Coil ICD Lead Systems: Is There Any Difference?
Authors: Rasoul Mokabberi, Afsaneh Haftbaradaran M., Shruthi Pranesh, Anil Kumar, Xiaoqin Tang, Randle Storm, Jess Oren, pughazendhi Vijayaraman, Gopi Dandamudi
Journal: Circulation (2011)

Background: Single coil implantable cardioverter defibrillator (ICD) lead systems are less often utilized even though no significant difference in defibrillation threshold (DFT) has been demonstrated in comparison to dual coil ICDs. The superior vena cava (SVC) coil is associated with an active fibrotic reaction within the SVC, which can increase complication risk during extraction. We compared DFTs between single vs. dual coil ICD leads at initial implantation. Methods: Two hundred and fifty three consecutive patients who underwent new ICD implantation from 9/2008 to 9/2010 at our institution were retrospectively analyzed. Mean follow-up was 14.6±7.3 months. Results: Single coil was used more frequently vs. dual coil (172 vs. 81 pts). Age was lower in single coil group (63.0 vs. 72.1, p&lt;0.001). There was no significant difference (single vs. dual coil, p&gt;0.05) in sex, LV EF (28.9 vs. 26.6%), body mass index, ischemic cardiomyopathy, primary prophylaxis indication, procedural complications, lead extraction during follow up, and mortality. DFT testing was performed in 92% and 86% of patients in each group. There was no significant difference in DFTs (16.6±2.8 vs. 17.3±3.2J, p=0.13), DFT safety margin (18.9±3.1 vs. 18.9±3.8J, p=0.96) and successful shocks during follow up between the two groups. The single coil group with ischemic cardiomyopathy had lower DFT (16.1±2.5 vs. 17.9±3.4J, p=0.002), but single coil group with non-ischemic cardiomyopathy had higher DFT (17.7±3.1 vs. 15.9±2.3J, p= 0.03). Right-sided implants in single coil group had lower DFTs (16.4±4 vs. 18.3±2.4J, p=0.008). Two BMI groups (BMI &lt;30 [25±2.5] vs. BMI ≥30 [35.5±4.2]) were analyzed. In BMI &lt;30 group, DFT was lower in single coil group (16.6±3.0J vs. 18.3±3.5J, p=0.008). In BMI ≥30 group, there was no significant difference in DFT between two groups (16.7±2.6 vs. 16.1±2.5, p=0.30). Conclusion: Single coil ICD leads offer adequate safety margins in patients with ischemic and non-ischemic cardiomyopathy irrespective of sex, LV function, implant site, and BMI. They should offer a better safety profile during lead extractions.
Predictive value of 677C&gt;T and 1298A&gt;C polymorphisms of the methyletetrahydrofolate reductase (MTHFR) gene in patients treated with FOLFOX therapy
Authors: M. Etienne-Grimaldi, F. Maindrault-Goebel, B. Chibaudel, J. L. Formento, M. Francoual, A. de Gramont, G. Lledo, T. André, M. Mabro, G. A. Milano
Journal: Journal of Clinical Oncology (2008)

4116 Background: To test the predictive value of germinal gene polymorphisms potentially related to fluorouracil (FU) and oxaliplatin (Oxa) pharmacodynamics on toxicity, response rate, progression-free and overall survival. Methods: As part of a phase II OPTIMOX 2 trial by the GERCOR group, 117 patients were enrolled in a prospective pharmacogenetic study conducted in patients with advanced colorectal cancer, all receiving a modified FOLFOX7 therapy (65 men, 52 women, mean age 64.7, range 31–80). The maximum observed toxicity (NCI-CTCAE) for each toxic pattern, along with the best response (RECIST) were recorded. Median follow-up was 19.7 months. Gene polymorphisms relevant for FU: thymidylate synthase (TS, 28 bp repeats including the G>C mutation + 6 bp deletion in 3’UTR) and MTHFR (677C>T + 1298A>C), as well as for Oxa: GSTπ (105Ile>Val + 114Ala>Val), ERCC1 (118AAT>AAC) and ERCC2 (XPD, 751Lys>Gln) were determined (blood mononuclear cells). Results: None of the gene polymorphisms were predictive of toxicity, considered either as the maximum observed grade, or as a score equal to the sum of each toxicity pattern grade. The best response was complete response (CR) in 2 patients, partial response (PR) in 64 patients, stable disease in 47 patients and progression for 4 patients. Both the 677C>T (p = 0.022) and 1298A>C (p = 0.004) MTHFR genotypes were linked to clinical responsiveness (CR+PR, 56.4 %), with the rare allele theoretically favoring elevated reduced folate concentrations, linked to improved responsiveness. Importantly, the number of favorable MTHFR alleles (i.e. 677T and 1298C) revealed response rates of 37.1%, 53.3%, 66.1% and 80.0% in patients bearing 0, 1, 2 or 3 favorable alleles (N = 35, 15, 56 and 10), respectively (P = 0.018). None of the other genotypes were linked to treatment responsiveness. In addition, none of the analyzed polymorphisms were related to progression-free or overall survival. Conclusions: These results establish the role of MTHFR germinal polymorphism as a strong predictor of response for FOLFOX therapy in patients with advanced colorectal cancer. No significant financial relationships to disclose.
Genetics and psychiatry: past discoveries, current dilemmas, and future directions
Authors: H Pardes, C A Kaufmann, H A Pincus, A West
Journal: American Journal of Psychiatry (1989)

Family, twin, and adoption studies have suggested an important role for hereditary factors in the etiology and pathogenesis of several psychiatric disorders. Advances in molecular and statistical genetics may very well reveal the identity of these factors, which may include single genes. Linked markers, critical to the discovery of abnormal genes in several medical conditions, have been reported for Huntington's disease, Alzheimer's disease, bipolar disorder, and schizophrenia. Psychiatric disorders pose particular problems (etiologic heterogeneity, incomplete penetrance, variable expressivity) for genetic research. New practical and ethical questions also arise. Nevertheless, knowledge may emerge that will suggest new approaches to diagnosis, prevention, and treatment.
A Sleeping Beauty forward genetic screen identifies new genes and pathways driving osteosarcoma development and metastasis
Authors: Branden S Moriarity, George M Otto, Eric P Rahrmann, Susan K Rathe, Natalie K Wolf, Madison T Weg, Luke A Manlove, Rebecca S LaRue, Nuri A Temiz, Sam D Molyneux, Kwangmin Choi, Kevin J Holly, Aaron L Sarver, Milcah C Scott, Colleen L Forster, Jaime F Modiano, Chand Khanna, Stephen M Hewitt, Rama Khokha, Yi Yang, Richard Gorlick, Michael A Dyer, David A Largaespada
Journal: Nature Genetics (2015)
Molecular Analysis of Rh Transcripts and Polypeptides From Individuals Expressing the DVI Variant Phenotype: An RHD Gene Deletion Event Does Not Generate All DVIccEe Phenotypes
Authors: Neil D. Avent, Wendy Liu, Jeff W. Jones, Marion L. Scott, Douglas Voak, Martin Pisacka, Julie Watt, Anne Fletcher
Journal: Blood (1997)
Pulmonary tuberculosis in children from family contacts
Authors: Larissa Gorbach
Journal: European Respiratory Journal (2014)

Background: The problem of tuberculosis in children from family contacts is urgent nowadays. The reason is that children from family contacts fall ill by tuberculosis more often, than other children.

Objective: The study of 96 cases of pulmonary tuberculosis in children from family contacts.

Design/Methods: The focus group included 48 children from families with cases of death from tuberculosis and 48 children from families without cases of death from tuberculosis.

Analysis of history of disease, clinical, bacteriological, X-ray methods and statistical analysis have been applied.

Results: Both groups did not differ by quantity of boys and girls, by average age.

Children with pulmonary tuberculosis often had no complaints.

Cavities were recorded in 11 children (22,9%) from families with cases of death and in 13 children (27,1%) from families without cases of death (χ2 = 0,056; p = 0,814). The excretion of Mycobacterium tuberculosis was determined in 16 children (33,3%) from families with cases of death and 11 children (22,9%) from families without cases of death (χ2 = 0,824;p = 0,364).

The frequency of multidrug-resistant tuberculosis in the groups differed. Multidrug-resistant tuberculosis was observed in 11 children (22,9%) from families with cases of death and 2 children (4,2%) from families without cases of death (χ2 = 5,694; p = 0,017).

![Figure][1] 



Conclusions: Children from families with cases of death from tuberculosis often have drug-resistant tuberculosis.

 [1]: pending:yes
Antidepressants prescribed for conditions other than depression
Authors: A P Fletcher
Journal: BMJ (1995)

problem of efficacy has to be incorporated into the discussion on antidepressants and suicide.5That debate arose from a Swedish study analogous to that of Jick and colleagues, in which a large proportion of the patients committing suicide had not taken antidepressants.2Interestingly, in that study mianserin and moclobemide were associated with a high rate of suicide relative to their overall consumption.Several clinical reports suggest that moclobemide is less effective than tricyclic anti- depressants.
Knowledge of pulse oximetry among general practitioners in south Australia
Authors: Quirine Huijgen, Tanja Effing, Kerry Hancock, Tjard Schermer, Alan Crockett
Journal: European Respiratory Journal (2011)

Introduction: Research in different hospital settings has shown that clinicians' understanding of pulse oximetry is limited. No data are available about knowledge among general practitioners (GPs).

Aims and objectives: The aim of our study was to gain insight into the current knowledge, interpretative skills of GPs with regard to pulse oximetry.

Methods: A cross-sectional observational survey was performed. Overall knowledge of GPs regarding pulse oximetry was evaluated with help of a newly developed questionnaire (based on previously reported surveys). Secondary, the influence of saturation values on GP decision making was explored. GPs were asked to complete the questionnaire: 1) via a newsletter (containing a digital link to the questionnaire) that was emailed to GP networks in and around Adelaide (Australia); 2) in person during a workshop and conference.

Results: 42 GPs and 4 GP registrars participated. From the participants, 60.9% owned a pulse oximeter and 76.1% had experience with pulse oximetry. 58.7% believed they had not received adequate training in pulse oximetry. The overall mean score was 35.0% (SD 19.1%). A significant negative correlation between years of experience in general practice and knowledge was found (p<0.05). GPs with pulse oximetry experience scored significantly higher (p<0.05). Knowledge of the saturation value did not seem to influence the management plans of the GPs.

Conclusions: Knowledge of pulse oximetry seems poor among GPs and GP registrars. Good training is essential to prevent errors in the interpretation of pulse oximetry readings, which may have the potential of causing harm to patients.
d-fenfluramine treatment of binge eating disorder
Authors: A Stunkard, R Berkowitz, C Tanrikut, E Reiss, L Young
Journal: American Journal of Psychiatry (1996)

The purpose of this study was to assess the efficacy of the appetite suppressant d-fenfluramine in the treatment of binge eating disorder.The authors conducted an 8-week double-blind, placebo-controlled clinical trial of the drug with 28 severely obese female patients meeting full criteria for binge eating disorder. The primary outcome measure was number of binges per week, as recorded in binge diaries and reviewed weekly with the principal investigators.Random effects linear regression analysis showed that the rate of binge eating in the d-fenfluramine group fell three times more rapidly than that in the placebo group, a result that was both clinically and statistically significant. At 4-month follow-up the binge frequency of the d-fenfluramine group had increased to pretreatment levels and no longer differed from that of the placebo group.d-Fenfluramine reduced the frequency of binge eating by obese women with binge eating disorder.
Abstract 9813: Verifying Cardiac Mechanics From 3D-Wall Motion Tracking Processed for Rotation Determination
Authors: Sreyas Ravi, Goshina Meman, Meihua Zhu, Cole Streiff, Austin Park, Muhammad Ashraf, David J Sahn
Journal: Circulation (2013)

Background: This study assessed 3D-Wall Motion Tracking (3D-WMT) for determining rotation of a pumped heart model. Methods: Latex balloons were sutured inside the LV of 10 pig hearts and attached to a pulsatile pump. The heart phantom and a Toshiba Matrix Array PST-25SX 2.5 MHz Transducer were fixed within a water filled tank. The hearts were firmly attached to a rotating plate at the base and lightly affixed at the apex, and pumped at a stroke volume of 50ml while the base of the heart was variably rotated at 0, 3,5,7,10,12 and 15 degrees. Three images were acquired at each rotation setting and a 3D WMT program was used to assess cardiac rotation. Results: The 3D-WMT derived rotation angles were found to be most precise at physiologically normal values (3-5°), but consistently underestimated at angles greater than 5°. For the 3D-WMT calculated rotation, the mean and standard deviation at 0°,3°,5°,7°,10°,12°,15° was 1.049° ± 0.688°, 2.80° ± 0.647°, 4.178° ± 0.835°, 5.723° ± 0.851°,7.809° ± 0.815°, 9.131° ± 1.481°,11.144° ± 1.307°, respectively. The P value is less than 0.0001 A Bland Altman plot showed 96% of data were within a 95% confidence interval and a slight underestimation. Conclusions: Despite observed underestimation at higher degrees of rotation, Toshiba 3D-WMT may provide clinically important determinations of LV rotation.
Abstract 1145: Drug-Eluting Stents in the Treatment of Intermediate Lesions: Pooled Analysis from 14 Randomized Clinical Trials
Authors: Evgenia Nikolsky, Roxana Mehran, Gary S Mintz, George Dangas, Stephen G Ellis, Alexandra J Lansky, Martin Fahy, Dennis Donohoe, Gregg W Stone, Giora Weisz, Martin B Leon, Jeffrey W Moses
Journal: Circulation (2008)

Background Treatment of patients with hemodynamically insignificant intermediate coronary stenoses using bare-metal stents (BMS) has not shown to improve clinical outcomes and therefore is not reco...
Use of Advanced Magnetic Resonance Imaging Techniques in Neuromyelitis Optica Spectrum Disorder
Authors: Stephane Kremer, Felix Renard, Sophie Achard, Marco A. Lana-Peixoto, Jacqueline Palace, Nasrin Asgari, Eric C. Klawiter, Silvia N. Tenembaum, Brenda Banwell, Benjamin M. Greenberg, Jeffrey L. Bennett, Michael Levy, Pablo Villoslada, Albert Saiz, Kazuo Fujihara, Koon Ho Chan, Sven Schippling, Friedemann Paul, Ho Jin Kim, Jerome de Seze, Jens T. Wuerfel, Philippe Cabre, Romain Marignier, Thomas Tedder, Danielle van Pelt, Simon Broadley, Tanuja Chitnis, Dean Wingerchuk, Lekha Pandit, Maria Isabel Leite, Metha Apiwattanakul, Ingo Kleiter, Naraporn Prayoonwiwat, May Han, Kerstin Hellwig, Katja van Herle, Gareth John, D. Craig Hooper, Ichiro Nakashima, Douglas Sato, Michael R. Yeaman, Emmanuelle Waubant, Scott Zamvil, Olaf Stüve, Orhan Aktas, Terry J. Smith, Anu Jacob, Kevin O’Connor
Journal: JAMA Neurology (2015)

Brain parenchymal lesions are frequently observed on conventional magnetic resonance imaging (MRI) scans of patients with neuromyelitis optica (NMO) spectrum disorder, but the specific morphological and temporal patterns distinguishing them unequivocally from lesions caused by other disorders have not been identified. This literature review summarizes the literature on advanced quantitative imaging measures reported for patients with NMO spectrum disorder, including proton MR spectroscopy, diffusion tensor imaging, magnetization transfer imaging, quantitative MR volumetry, and ultrahigh-field strength MRI. It was undertaken to consider the advanced MRI techniques used for patients with NMO by different specialists in the field. Although quantitative measures such as proton MR spectroscopy or magnetization transfer imaging have not reproducibly revealed diffuse brain injury, preliminary data from diffusion-weighted imaging and brain tissue volumetry indicate greater white matter than gray matter degradation. These findings could be confirmed by ultrahigh-field MRI. The use of nonconventional MRI techniques may further our understanding of the pathogenic processes in NMO spectrum disorders and may help us identify the distinct radiographic features corresponding to specific phenotypic manifestations of this disease.
Immunogenicity and Cross-reactivity of Syngeneic Murine Melanomas
Authors: Cherrie Donawho, Margaret L. Kripke
Journal: Cancer Communications (1990)

Non-melanoma skin cancers induced in mice by chemical carcinogens or ultraviolet radiation are often antigenic but rarely induce cross-protective immunity when tested by in vivo transplantation methods. We wished to determine whether melanocytic skin tumors behave similarly or whether they exhibit cross-reactive antigens in vivo. Three melanomas induced in C3H/HeNCr(MTV-) mice by initiation with ultraviolet radiation and promotion with croton oil or initiation with 7,12-dimethyl-benz[a]anthracene and promotion with 12-O-tetradecanoyl-phorbol-13-acetate or croton oil plus ultraviolet radiation were tested for immunogenicity and cross-reactivity in vivo. The three melanomas were highly immunogenic, and all induced some degree of protection against the other melanomas. Non-melanoma skin cancers induced by the same carcinogens were less immunogenic and did not immunize against the melanomas. We conclude that unlike other skin cancers, melanocytic tumors induced by chemical carcinogens and ultraviolet radiation are highly cross-reactive in vivo and thus represent a unique subset of murine skin cancers.
Abstract 15813: The Role of Endogenous and Exogenous Hydrogen Sulfide Following Pressure Overload Induced Hypertrophy and Heart Failure
Authors: Kazuhisa Kondo, Shashi Bhushan, Marah E Condit, Adrienne L King, Benjamin L Predmore, Rui Wang, Gabriel Gojon, David J Lefer
Journal: Circulation (2011)

Introduction: Hydrogen sulfide (H2S) is a potent signaling molecule that plays a critical role in cardiovascular homeostasis. Cystathionine gamma-lyase (CSE) produces H2S in the heart. The aim of this study was to investigate a role of both endogenous and exogenous H2S in pressure overload induced heart failure. Methods: Male CSE Knockout (KO), wild type control (WT) mice, and male C57/BL6J mice (12-14 weeks old, n=15-20) were investigated. Baseline echocardiography was performed followed by transverse aortic constriction (TAC) to create pressure overload. In additional studies C57/BL6J mice received either vehicle (VEH) or a H2S donor. Mice received a novel, orally active H2S donor (NANT-1002) at a dose of 20 mg/kg/day delivered in the diet. Follow-up echocardiography was performed at 12 weeks following TAC surgery. Results: CSE KO and WT mice showed equivalent hypertrophy after 3 weeks of TAC surgery, but CSE KO mice exhibited significantly exacerbated cardiac dysfunction. Left ventricular (LV) ejection...