The Cardiomyopathy of Obstructive Sleep Apnea
Authors: Robert Joseph Thomas
Journal: Annals of Internal Medicine (1996)

Letters1 September 1996The Cardiomyopathy of Obstructive Sleep ApneaRobert Joseph Thomas, MDRobert Joseph Thomas, MDAlvin C. York Veterans Affairs Medical Center, Murfreesboro, TN 13129Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-125-5-199609010-00029 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:A 44-year-old man was hospitalized for the management of recently diagnosed and refractory congestive cardiac failure, deep venous thrombosis of the left lower extremity, atrial fibrillation, mild hypothyroidism, and morbid obesity (weight, 450 pounds). When questioned, the patient admitted to severe excessive daytime somnolence.Blood gas analysis showed the following results: pH, 7.31; Pao2, 51.3 mm Hg; Pco2, 71.3 mm Hg; and HCO3, 41.4 mEq/L. The ejection fraction was estimated to be 30% by echocardiography and radionuclide ventriculography. Polysomnography established severe obstructive sleep apnea with an apnea–hypopnea index of 95. The response to nasal continuous positive airways ...References1. Malone S, Liu PP, Holloway R, Rutherford R, Xie A, Bradley TD. Obstructive sleep apnea in patients with dilated cardiomyopathy: effects of continuous positive airway pressure. Lancet. 1991; 338:1480-4. Google Scholar2. Zohar Y, Talmi YP, Frenkel H, Finkelstein Y, Rudnicki C, Fried M, et al. Cardiac function in obstructive sleep apnea patients following uvulopalatopharyngoplasty. Otolaryngol Head Neck Surg. 1992; 107:390-4. Google Scholar3. Guilleminault C, Motta J, Mihm F, Melvin K. Obstructive sleep apnea and cardiac index. Chest. 1986; 89:331-4. Google Scholar4. Shiomi T, Guilleminault C, Stoohs R, Schnittger I. Leftward shift of the interventricular septum and pulsus paradoxus in obstructive sleep apnea syndrome. Chest. 1991; 100:894-902. Google Scholar5. Garpestad E, Parker JA, Katayama H, Lilly J, Yasuda T, Ringler J, et al. Decrease in ventricular stroke volume at apnea termination is independent of oxygen desaturation. J Appl Physiol. 1994; 77:1602-8. Google Scholar Author, Article, and Disclosure InformationAuthors: Robert Joseph Thomas, MDAffiliations: Alvin C. York Veterans Affairs Medical Center, Murfreesboro, TN 13129 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byChange in quality of life with nasal CPAP in patients with OSASleep-Disordered Breathing in Patients With Idiopathic Cardiomyopathy.Sleep-related breathing disorders and cardiovascular diseaseThe prevalence of carotid atheromas seen on panoramic radiographs of patients with obstructive sleep apnea and their relation to risk factors for atherosclerosisQuality of Life in Patients with Obstructive Sleep Apnea 1 September 1996Volume 125, Issue 5Page: 425KeywordsApneaBloodEjection fractionGas analysisHeart failureSevere blood lossSleep apneaStrokeSystoleWeight loss ePublished: 15 August 2000 Issue Published: 1 September 1996 Copyright & PermissionsCopyright © 1996 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...