tbuckley/cabot-search huggingface dataset:
Manpower and training
Authors: P. F Jones
Journal: BMJ (1986)

<h3>Background</h3> Adverse events (AEs) after outpatient orthopaedic surgery are common, but difficult to detect. Electronic health records facilitate abstraction of large quantities of data, and may allow automated identification of ‘triggers’ or clues indicating the possibility of an AE. We evaluated electronic health record-based triggers to detect AEs after outpatient orthopaedic surgery. <h3>Methods</h3> The medical records of 1464 patients undergoing outpatient surgical procedures in one of five orthopaedic services at our institution were manually reviewed for the occurrence of 90-day postoperative AEs. We used electronic health records to identify triggers suggestive of an AE. Each trigger was evaluated for positive predictive value (PPV). We constructed a logistic regression model to determine triggers associated with AEs and used the beta coefficients derived from the model to produce a formula for the likelihood of identifying an AE in the medical record. <h3>Results</h3> The overall rate of 90-day AEs was 10%, with surgical site infection being the most common (3.3%). Electronic triggers with the highest PPVs for the occurrence of 90-day AEs were antibiotic prescription (75%), emergency department visit (41%), bone/joint or blood culture (41%), repeat surgery (39%) and consult with infectious disease specialist (33%). Using our formula to predict the likelihood of identifying an AE in the medical record, a predicted probability of &gt;0.10 had a specificity of 80% and sensitivity of 53% for actual AE. <h3>Conclusions</h3> Electronic health record-based triggers may facilitate quality-improvement efforts to monitor morbidity after outpatient orthopaedic surgery. Further research is needed to understand the optimal use of electronic triggers as surgical quality indicators and as screening tools to flag cases for manual review. <h3>Level of evidence</h3> Level III, prognostic study.
Polymyxin B Hemoperfusion and Mortality in Abdominal Septic Shock
Authors: Yujiro Kida
Journal: JAMA (2009)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
TONSILLECTOMY, THOROUGH, PAINLESS AND SAFE.
Authors: E. FLETCHER INGALS
Journal: JAMA (1905)

"What is worth doing at all is worth doing well," is a truism especially applicable to surgical procedures, for no operation should ever be undertaken excepting for the patient's best interests. We are all searching, therefore, for something that is better, whether it be new or whether it be simply a modification of the old. That the ancient operation for tonsillectomy is susceptible of improvement goes without saying when we consider some of the important conditions and when we witness some of its lamentable results. An unusual case which recently came under my observation induces me to bring up again this well-worn subject in the belief that there are many surgeons, even among laryngologists, who are not familiar with the technic of an operation that to me appears more thorough and much safer than the methods generally adopted. The case referred to was that of a gentleman about
Nobel prize winner calls for preventive approach to fight epidemics and disease
Authors: J. Zarocostas
Journal: BMJ (2009)

A Nobel prize winner has called for a new approach in medicine that focuses on prevention rather than cure.

Luc Montagnier, a French virologist and the co-recipient of the 2008 Nobel prize for medicine, told a global forum on 26 October that this could be achieved by using innovative technologies and encouraging a drastic change in the mentality of the medical community and the drug industry.

Professor Montagnier, addressing delegates at the Biobridge 2009 regenerative medicine conference in Geneva, said that technologies, especially nanotechnologies, are being developed that can identify molecular events …
Looking for Mozart ears.
Authors: A Paton, A L Pahor, G R Graham
Journal: BMJ (1986)

Our quest for Wolfgang Amadeus Mozart (1756-91) in the realms of otology was prompted by the case of a young girl with several developmental abnormalities which included curiously flat and rounded ears. These were called Mozart ears, but reference to currently available textbooks on diseases of the ear yielded only scanty descriptions, and a straw poll among colleagues in other disciplines disclosed no one who knew what they were or why they were so called. The questions we asked were: What exactly are Mozart ears? How common are they? and How have they come by such a distinguished eponym? After three years of intermittent investigation our findings are still incomplete, but they may encourage others to provide solutions to an intriguing puzzle.
Moles and Site-Specific Risk of Nonfamilial Cutaneous Malignant Melanoma in Womene
Authors: M. A. Weinstock, G. A. Colditz, W. C. Willett, M. J. Stampfer, B. R. Bronstein, M. .C Mihm, F. E. Speizer
Journal: JNCI Journal of the National Cancer Institute (1989)

We examined the relationship between self-reported mole counts and cutaneous melanoma with respect to anatomic site in 110 case and 231 control female nurses. Counts of moles on the lower leg were better predictors of melanoma risk than were counts of moles on the arm. The relative risk for the highest quintile of lower leg mole counts versus no lower leg moles was 4.2. Mole counts at each site (arm, thigh, and lower leg) were associated with risk of melanoma of the trunk and lower leg, but none were associated with the risk of melanoma of the upper extremity. The absence of direct site-specificity suggests that mole counts primarily indicate systemic melanoma risk, rather than direct risk from the moles themselves.
Association Between HLA Antigens and Different Types of Hypersomnia
Authors: J. Montplaisir, G. Poirier, F. Decary, A. Lebrun
Journal: JAMA (1986)

<h3>To the Editor.—</h3> A close association has been reported between HLA antigens and narcolepsy.<sup>1-3</sup>Over the past two years we compared various types of hypersomnia in 56 patients. Thirty-four narcoleptics and 13 patients with idiopathic central nervous system hypersomnia, all unrelated and white, were included in the statistics (Table). These patients were diagnosed on the basis of a clinical interview and polygraphic recordings of at least five daytime naps. Polygraphic recordings were scored blind with regard to the results of HLA determinations. All narcoleptics exhibited excessive daytime sleepiness, cataplexy, and sleep-onset rapid eye movement periods during nap recordings. All idiopathic hypersomniacs had severe excessive daytime sleepiness without cataplexy and short sleep latencies but no sleep-onset rapid eye movement periods during naprecordings. Sleep apnea and nocturnal myoclonus were ruled out in all idiopathic hypersomniac patients by two all-night polygraphic recordings. Fifty-four HLA antigens of loci A, B, C, and
Targeted Molecular Probes for Imaging Atherosclerotic Lesions With Magnetic Resonance Using Antibodies That Recognize Oxidation-Specific Epitopes
Authors: Karen C. Briley-Saebo, Peter X. Shaw, Willem J.M. Mulder, Seung-Hyuk Choi, Esad Vucic, Juan Gilberto S. Aguinaldo, Joseph L. Witztum, Valentin Fuster, Sotirios Tsimikas, Zahi A. Fayad
Journal: Circulation (2008)

Background— Oxidized low-density lipoprotein plays a key role in the initiation, progression, and destabilization of atherosclerotic plaques and is present in macrophages and the lipid pool. The aim of this study was to assess the feasibility of magnetic resonance imaging of atherosclerotic lesions in mice using micelles containing gadolinium and murine (MDA2 and E06) or human (IK17) antibodies that bind unique oxidation-specific epitopes. Methods and Results— MDA2 micelles, E06 micelles, IK17 micelles, nonspecific IgG micelles, and untargeted micelles (no antibody) were prepared and characterized with respect to pharmacokinetics and biodistribution in wild-type and atherosclerotic apolipoprotein E–deficient (apoE −/− ) mice. Magnetic resonance imaging was performed at 9.4 T over a 96-hour time interval after the administration of 0.075–mmol Gd/kg micelles. MDA2, E06, and IK17 micelles exhibited a longer plasma half-life than IgG or untargeted micelles in apoE −/− but not wild-type mice. In apoE −/− mice, MDA2 and IK17 micelles showed maximal arterial wall uptake at 72 hours and E06 micelles at 96 hours, manifested by 125% to 231% enhancement in magnetic resonance signal compared with adjacent muscle. Confocal microscopy revealed that MDA2, IK17, and E06 micelles accumulated within atherosclerotic lesions and specifically within macrophages. Intravenous injection of free MDA2 before imaging with MDA2 micelles resulted in significantly diminished magnetic resonance signal enhancement. IgG micelles and untargeted micelles showed minimal enhancement in apoE −/− mice. There was no significant signal enhancement with all micelles in wild-type mice. Conclusions— Magnetic resonance imaging with micelles containing gadolinium and oxidation-specific antibodies demonstrates specific targeting and excellent image quality of oxidation-rich atherosclerotic lesions.
Case 29-1975
Authors: Richard C. Cabot, Robert E. Scully, James J. Galdabini, Betty U. McNeely, Lewis E. Braverman, Austin L. Vickery
Journal: New England Journal of Medicine (1975)

Presentation of CaseA 72-year-old man was admitted to the hospital because of urinary frequency.He was well until 12 years previously, when he was admitted to the hospital because of superior mediastinal obstruction. An x-ray film of the chest (Fig. 1) showed a mass, 8.5 cm in diameter, that extended from the middle mediastinum into the superior mediastinum and the right-upper-lung field and displaced the esophagus and trachea to the left and posteriorly. A nodular density, 1.5 cm in diameter, was seen in the left-lower-lung field at the level of the fifth anterior intercostal space, and another was present . . .
Current Psychiatric Therapies; An Annual Publication.
Authors: Marjorie C. Meehan
Journal: JAMA (1963)

Everybody talks about the overwhelming flood of literature in each scientific and medical field, and occasionally someone tries to do something about it. One promising effort in psychiatry is Masserman's series of annual volumes on therapy. Now, for the third time, he has selected a number of leaders practicing a variety of therapeutic methods, and persuaded them to discuss their own areas. These papers give the experience and outlook of the authors with recognition of related work by others, but none are of the annual "summary of the literature" type. The 30 papers making up volume 3 cover many topics such as psychotherapy, pharmacologic facilitation, treatment of homosexuals, observations on children of the Kibbutz, group therapy, and projects in institutions. Of the 44 writers, only one, Selwyn Brody, has contributed to an earlier volume of this series. Francis Braceland's essay on the art of psychotherapy is especially delightful, and a
High-Resolution Ultrasound Perfusion Imaging of Therapeutic Angiogenesis
Authors: Tuomas T. Rissanen, Petra Korpisalo, Henna Karvinen, Timo Liimatainen, Svetlana Laidinen, Olli H. Gröhn, Seppo Ylä-Herttuala
Journal: JACC. Cardiovascular imaging (2008)
Autogenous vein grafting in atheromatous rabbits
Authors: P. KING, J. P. ROYLE
Journal: Cardiovascular Research (1972)

Journal Article Autogenous vein grafting in atheromatous rabbits Get access PETER KING, PETER KING 1 From the Department of Surgery, University of Melbourne, Austin Hospital, Heidelberg, Victoria,3084, Australia 1 Present address: Mooroopna and District Base Hospital, Mooroopna, Victoria, 3629, Australia. Search for other works by this author on: Oxford Academic PubMed Google Scholar JOHN P. ROYLE JOHN P. ROYLE From the Department of Surgery, University of Melbourne, Austin Hospital, Heidelberg, Victoria,3084, Australia Search for other works by this author on: Oxford Academic PubMed Google Scholar Cardiovascular Research, Volume 6, Issue 6, November 1972, Pages 627–633, https://doi.org/10.1093/cvr/6.6.627 Published: 01 November 1972
Morphine and dryness of the mouth.
Authors: I. D. White, P. J. Hoskin, G. W. Hanks, J. M. Bliss
Journal: BMJ (1989)

<h3>Abstract</h3> Although excessive lipid accumulation is a hallmark of obesity-related pathologies, some lipids are beneficial. Oleic acid (OA), the most abundant monounsaturated fatty acid (FA), promotes health and longevity. Here we show that OA benefits <i>C. elegans</i> by activating the endoplasmic reticulum (ER)-resident transcription factor SKN-1A (Nrf1/NFE2L1) in a lipid homeostasis response. SKN-1A/Nrf1 is cleared from the ER by the ER-associated degradation (ERAD) machinery and stabilized when proteasome activity is low, and canonically maintains proteasome homeostasis. Unexpectedly, OA increases nuclear SKN-1A levels independently of proteasome activity, through lipid droplet (LD)-mediated enhancement of ERAD. In turn, SKN-1A reduces steatosis by reshaping the lipid metabolism transcriptome, and mediates longevity from OA provided through endogenous accumulation, reduced H3K4 trimethylation, or dietary supplementation. Our findings reveal a surprising mechanism of FA signal transduction, and a lipid homeostasis pathway that provides strategies for opposing steatosis and aging, and may mediate benefits of the OA-rich Mediterranean diet.
Sexual Activity Triggering Myocardial Infarction
Authors: Robert F. DeBusk
Journal: JAMA (1996)

Contemporary therapy for acute myocardial infarction (MI), including thrombolytic and other adjunctive drug therapies<sup>1</sup>and direct percutaneous transluminal coronary angioplasty,<sup>2</sup>has dramatically lowered the short-term mortality from this condition. Moreover, lipid-lowering drug therapy, aspirin, and β-blockers,<sup>3</sup>as well as angiotensin-converting enzyme inhibitors for left ventricular dysfunction,<sup>4</sup>given in the postacute phase, have decreased not only the rate of reinfarction and death but also the rate of rehospitalization for unstable angina pectoris and the need for coronary revascularization.<sup>5</sup>In short, the prospects for a rapid and complete recovery from acute MI and avoidance of future cardiac events have never been better. However, despite these favorable prospects, physicians and patients are too often burdened by the misconception that sexual activity after acute MI is dangerous. See also p 1405. The report of Muller et al<sup>6</sup>in this issue ofThe Journalindicates that the actual risk
The Implications of Changing Medical Education for Psychiatric Training Institutions
Authors: MILTON H. MILLER, WILLIAM F. FEY, NORMAN S. GREENFIELD
Journal: American Journal of Psychiatry (1970)

The authors describe an experimental program at the University of Wisconsin that will integrate medical school, internship, and psychiatric residency years to allow selected medical students to complete their basic medical and psychiatric specialty training in six years. The first students to undertake the last three years of this six-year program are currently medical school juniors and will begin the new sequence next year. The program represents, in the authors' thinking, a logical extension of the progression of change within many areas of medical education since World War II.
Bread — A Dietary Source of Large Quantities of Iodine
Authors: W. T. London, R. L. Vought, F. A. Brown
Journal: New England Journal of Medicine (1965)

DURING an outpatient study of iodine intake and excretion, we encountered cases of very high iodine intakes (1100 to 1300 microgm. per day),1 and we were not able to identify the sources of iodine in those diets. Subsequently, we learned that some bakeries add iodate to commercial bread mix as a "dough conditioner."2 According to Food and Drug Administration regulations the maximum permissible quantity of any conditioner in dough is 0.0075 per cent by weight, or a possible 75 microgm. of iodine per gram of bread.3 To determine if bread was an actual or merely a potential source of iodine, . . .
A Dream of the Heart: The Life of John H. Gibbon, Jr, Father of the Heart-Lung Machine
Authors: Alan T. Marty
Journal: JAMA (1999)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The U.S. “New Patient” and “Transfer” Studies
Authors: John A Galloway, F Bruce Peck, S Edwin Fineberg, C Thomas Spradlin, John H Marsden, Debra Allemenos, Joann Ingulli-Fattic
Journal: Diabetes Care (1982)

The large-scale clinical trials of human insulin (recombinant DNA) in the United States consisted of a "New Patient" study and a "Transfer" study. The "New Patient" study involved 101 patients (38% type I) who have never received insulin and who were treated with human insulin and followed for 6 mo using NPH insulin alone or in combination with Neutral Regular Insulin (NRI). Shortly after treatment, serum glucose and total glycohemoglobin concentration fell. No patients developed insulin lipoatrophy or insulin allergy. Two patients developed insulin hypertrophy; in one, it was transient. Intradermal tests to varying dilutions of human insulin did not change over 6 mo. In addition, there was no evidence of development of antibodies to Escherichia coli polypeptide. Two-hundred-and-forty-three patients, 91% of whom had type I diabetes, were transferred in a controlled double-blind study from mixed beef-pork or purified pork insulin (PPI) either to human insulin or back to their previous insulin treatment and followed for 3 mo. While insulin dosage did not change, there was a slight increase in fasting serum glucose and a statistically significant increase in fasting ketonuria. There was no change in the frequency of the complications of insulin treatment. These limited data are consistent with the conclusion that NPH human insulin is slightly shorter acting than its animal insulin counterparts. Overall, human insulin is a safe, effective insulin.
Focus: Washington Scandal may hinder health reform
Authors: J Roberts
Journal: BMJ (1994)

Twenty years ago political scandal stopped the United States Congress from reforming the nation's health care system. It may happen again this year. In 1974 Richard Nixon's promise to overhaul the system was usurped by the Watergate scandal and by a congressional sex scandal. Wilbur Mills, the head of Congress's powerful ways and means committee, was brought down when he was arrested for drunkenness after being found with an exotic dancer in Washington. In 1994 the success of President Clinton's health care bill rests with a handful of men, several of whom face scandals just as the compromising gets underway.

The most serious threat is to Dan Rostenkowski of Chicago, Mills's successor on the ways and means committee, who has been the most powerful proponent of Mr Clinton's …
CMV a possible cause of hematospermia
Authors: Phil Gunby
Journal: JAMA (1983)

Cytomegalovirus (CMV) is another member of the herpes family that is under intense scrutiny. Already a suspect in acquired immune deficiency syndrome, it may possibly have a  in hematospermia.  Roger W. Koment, PhD, assistant professor of virology, Department of Microbiology, University of South Dakota School of Medicine, Vermillion, and Peter M. Poor, MD, Sioux City, Iowa, believe that the quantitative and temporal association of CMV with a two-year case of hematospermia in a young man suggests a causative role for the virus.  Reporting to a national conference on sexually transmitted diseases sponsored in Dallas by the Centers for Disease Control, Atlanta, Koment said that the patient was a heterosexually active graduate student in his mid-20s. He had been diagnosed as having CMV mononucleosis and was concurrently experiencing blood in his ejaculate.  The hematospermia persisted for more than two years; during that period, urine and semen specimens were collected at
Surgeons Grapple With Synovitis, Fractures Around Silicone Implants for Hand and Wrist
Authors: Teri Randall
Journal: JAMA (1992)

OTHER THAN breast implants, perhaps the most extensive body of research demonstrating adverse reactions to silicone can be found regarding implants for the hand and wrist. As early as 1974, researchers were reporting that silicone finger joint and wrist bone prostheses caused the formation of foreign-body granulomas (<i>Clin Orthop.</i>1974;98:231-232), silicone lymphadenopathy (<i>JAMA</i>. 1977;237:1463-1464), and silicone microparticle synovitis (<i>J Bone Joint Surg Am.</i>1982;64:581-585). Of concern to many hand surgeons is the sloughing of microparticles (&lt;100 μm) into the surrounding synovial tissue. Orthopedic surgeons agree that all implant materials shed microparticles to some degree during normal wear of the implant. Yet this appears to be particularly problematic with silicone implants in the wrist. Here, researchers have found that the silicone microparticles can set off an intense inflammatory response called microparticulate synovitis, in which inflamed synovial tissue invades bone adjacent to the prosthesis (Fig 1). In some patients, adjacent bone is