SEVERE SYSTEMIC REACTIONS TO PARA-AMINOSALICYLIC ACID: A CASE REPORT AND REVIEW OF THE LITERATURE
Authors: W J ALT, J R SPENGLER
Journal: Annals of Internal Medicine (1956)

Case Reports1 September 1956SEVERE SYSTEMIC REACTIONS TO PARA-AMINOSALICYLIC ACID: A CASE REPORT AND REVIEW OF THE LITERATUREW. J. ALT, J. R. SPENGLERW. J. ALTSearch for more papers by this author, J. R. SPENGLERSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-45-3-541 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptMild, untoward reactions to standard doses of para-aminosalicylic acid (PAS) are common. They consist for the most part of symptoms of gastrointestinal irritation. A detailed study by Cannemeyer, Thompson and Lichtenstein1has disclosed a less frequent but more severe pattern of hypersensitivity, consisting of fever, chills, pruritus, skin rash, conjunctivitis or pharyngitis, and lymphadenopathy. The incidence of these hypersensitivity reactions is reported to be approximately 2.5%.2Hepatosplenomegaly1, 8and Löffler's syndrome3, 4are rare manifestations. Hypersensitivity reactions generally develop eight to 45 days after onset of therapy with PAS.5Laboratory evidence of toxic hepatitis, when present, follows the appearance of...Bibliography1. CannemeyerThompsonLichtenstein WJRMR: Severe para-aminosalicylic acid hypersensitivity: blood and lymph node studies, Blood 10: 62, 1955. CrossrefMedlineGoogle Scholar2. WarringHowlett FCKS: Allergic reactions to para-aminosalicylic acid: report of 7 cases, including 1 case of Loeffler's syndrome, Am. Rev. Tuberc. 65: 235, 1952. MedlineGoogle Scholar3. AtwellPrior JJA: Allergic pneumonitis during chemotherapy for tuberculosis, Ann. Int. Med. 42: 190, 1955. LinkGoogle Scholar4. Tuchman H: Loeffler's reaction to para-aminosalicylic acid, Am. Rev. Tuberc. 70: 171, 1954. MedlineGoogle Scholar5. Korst DR: Severe reactions to para-aminosalicylic acid: a case report and brief review of literature, Ann. Int. Med. 40: 1011, 1954. LinkGoogle Scholar6. HayesWeiss RHM: Hypersensitivity reaction to oral para-aminosalicylic acid, Dis. of Chest 23: 645, 1953. CrossrefMedlineGoogle Scholar7. SteiningerKlopfensteinWoodruff WJMDCE: Fatal allergic reaction to para-aminosalicylic acid, Am. Rev. Tuberc. 69: 451, 1954. MedlineGoogle Scholar8. LichtensteinCannemeyer MRW: Severe para-aminosalicylic acid hypersensitivity simulating mononucleosis or hepatitis, J. A. M. A. 152: 606, 1953. CrossrefMedlineGoogle Scholar9. King DS: Tuberculosis, New England J. Med. 252: 96, 1955. CrossrefGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Madison, Wisconsin*Received for publication July 11, 1955.From the Veterans Administration Hospital, Madison, Wisconsin.Requests for reprints should be addressed to Frank C. Larson, M.D., Chief, Investigative Medicine Service, Veterans Administration Hospital, 2500 Overlook Terrace, Madison 5, Wisconsin. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byThe Predictability of Hypersensitivity to Anti-Tuberculous DrugsTHE MANAGEMENT OF HYPERSENSITIVITY REACTIONS TO ANTITUBERCULOSIS DRUGSSerum transaminase levels during treatment with isoniazid, streptomycin and pasCase 42-1961Hypersensitivity to para-aminosalicylic acidHepatitis Due to p-Aminosalicylic Acid HypersensitivityDRUG-INDUCED HEPATIC INJURY*HANS POPPER, M.D., F.A.C.P., FENTON SCHAFFNER, M.D., F.A.C.P.Reactions to Antituberculous Drugs11From the Veterans Administration Hospital, Baltimore, Maryland.Part V: Clinical Applications of Psoralens, and Related Materials: Clinical Experience with the Effect of Oral 8-Methoxy-Psoralen on the Pigmentary Responses of the Skin to Sunlight11From the Department of Dermatology and Syphilology of the New York University-Post-Graduate Medical School (Dr. Marion B. Sulzberger, Chairman) and the Skin and Cancer Unit of the University Hospital, New York, N.Y. 1 September 1956Volume 45, Issue 3Page: 541-547KeywordsHepatitis AHypersensitivityInflammationMyalgiaNauseaPeriodic acid SchiffPharyngitisPruritusRashesResearch laboratories ePublished: 1 December 2008 Issue Published: 1 September 1956 PDF downloadLoading ...