tbuckley/cabot-search huggingface dataset:
Abstract 19754: Effect of Naturally Random Allocation to Lower LDL-C Mediated by Polymorphisms in NPC1L1, HMGCR or Both on the Risk of Coronary Heart Disease: a 2x2 Factorial Mendelian Randomization Study
Authors: Brian A Ference, Faisal Majeed, Robert D Brook, Lowell Hedquist, Raju Penumetcha, John M Flack
Journal: Circulation (2014)

Introduction: Considerable uncertainty exists as to whether lowering LDL cholesterol (LDL-C) by inhibiting the NPC1L1 receptor with ezetimibe, either alone or in combination with an HMGCR inhibitor (statin), will reduce the risk of coronary heart disease (CHD). Hypothesis: We evaluated the effect of naturally random allocation to lower LDL-C mediated by polymorphisms in the NPC1L1 gene (as a proxy for treatment with ezetimibe), the HMGCR gene (as a proxy for treatment with a statin), or both (as a proxy for combination therapy) on the risk of CHD. Methods: We constructed an HMGCR genetic LDL-C score and an NPC1L1 genetic LDL-C score. We used these genetic scores to naturally randomize participants into one of four groups: reference, lower LDL-C mediated by NPC1L1 polymorphisms, lower LDL-C mediated by HMGCR polymorphisms, or lower LDL-C mediated by the combined effect of polymorphisms in both NPC1L1 and HMGCR. We then compared the risk of CHD (fatal or non-fatal myocardial infarction) among each group usi...
Abstract 19117: Mice Generated by Assisted Reproductive Technologies, a Model Organism for the Study of Epigenetic Mechanisms of Vascular Dysfunction in vivo
Authors: Emrush Rexhaj, Ariane Giacobino, Pascal Nicod, Marc Germond, Claudio Sartori, Urs Scherrer
Journal: Circulation (2010)

Background: Environmental influences acting early in life predispose to premature cardiovascular disease. Assisted reproductive technologies (ART) involve the manipulation of early embryos at a tim...
Finding the Os
Authors: Jeffrey Katz
Journal: JAMA (2001)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Effects of polysaccharopeptide from<i>Trametes Versicolor</i>and amoxicillin on the gut microbiome of healthy volunteers
Authors: Kumar Pallav, Scot E Dowd, Javier Villafuerte, Xiaotong Yang, Toufic Kabbani, Joshua Hansen, Melinda Dennis, Daniel A Leffler, David S Newburg, Ciarán P Kelly
Journal: Gut Microbes (2014)

Background Interactions between the microbial flora of the intestine and the human host play a critical role in maintaining intestinal health and in the pathophysiology of a wide variety of disorders such as antibiotic associated diarrhea, Clostridium difficile infection, and inflammatory bowel disease. Prebiotics can confer health benefits by beneficial effects on the intestinal microbiome, whereas antibiotics can disrupt the microbiome leading to diarrhea and other side effects.Aim To compare the effects of the prebiotic, polysaccharopeptide from Trametes versicolor, to those of the antibiotic, amoxicillin, on the human gut microbiomeMethods Twenty-four healthy volunteers were randomized to receive PSP, amoxicillin, or no treatment (control). Stool specimens were analyzed using bTEFAP microbial ecology methods on seven occasions over 8 weeks from each participant in the active treatment groups and on three occasions for the controls.Results Twenty-two of 24 participants completed the protocol. PSP led to clear and consistent microbiome changes consistent with its activity as a prebiotic. Despite the diversity of the human microbiome we noted strong microbiome clustering among subjects. Baseline microbiomes tended to remain stable and to overshadow the treatment effects. Amoxicillin treatment caused substantial microbiome changes most notably an increase in Escherichia/Shigella. Antibiotic associated changes persisted to the end of the study, 42 days after antibiotic therapy ended.Conclusions The microbiomes of healthy individuals show substantial diversity but remain stable over time. The antibiotic amoxicillin alters the microbiome and recovery from this disruption can take several weeks. PSP from T. versicolor acts as a prebiotic to modulate human intestinal microbiome composition.
Positional cloning of the zebrafish sauternes gene: a model for congenital sideroblastic anaemia
Authors: Alison Brownlie, Adriana Donovan, Stephen J. Pratt, Barry H. Paw, Andrew C. Oates, Carlo Brugnara, H. Ewa Witkowska, Shigeru Sassa, Leonard I. Zon
Journal: Nature Genetics (1998)
Counselling may be a better use of resources
Authors: D. Shickle, P. Donnelly, S. Hopkins, S. Vuilo
Journal: BMJ (1995)

EDITOR,—The ethical debate on in vitro fertilisation for older women and the interests of the potential child1 attracted considerable attention in the media, although the media failed to report that age cut offs have primarily been instituted on the basis of effectiveness. We agree that if the take home baby rate after in vitro fertilisation among older women were to improve then there would be a case for re-evaluating guidelines. We accept that if the interests of the child …
Abstract 11302: The Morphological Findings Of Very Late In-stent Restenosis After Bare-metal Stent Implantation: Optical Coherence Tomography Analysis
Authors: Maoto Habara, Mitsuyasu Terashima, Kenya Nasu, Yoshihisa Kinoshita, Etsuo Tsuchikane, Yasushi Asakura, Osamu Kato, Takahiko Suzuki
Journal: Circulation (2010)

Purpose: Although In-stent restenosis (ISR) after bare-metal stent (BMS) implantation peaks in the early phase, late ISR is occasionally observed beyond a few years after implantation. The mechanis...
THE MANAGEMENT OF THE SUICIDAL PATIENT
Authors: P B FRIEL, L M FRANK
Journal: Annals of Internal Medicine (1958)

Article1 September 1958THE MANAGEMENT OF THE SUICIDAL PATIENTPATRICK B. FRIEL, M.D., LUDWIG M. FRANK, M.D.PATRICK B. FRIEL, M.D.Search for more papers by this author, LUDWIG M. FRANK, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-49-3-632 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptIt is always sound medical practice to "treat the disease rather than the symptom," and this dictum is especially important when caring for patients who suffer from maladies where suicidal potentialities are present. Karl Menninger, in his book,Man Against Himselfpoints out the fallacies that lie behind the popular notion that "suicide is an escape from an intolerable life situation."1He stresses that suicide is the result of a deep-seated personality derangement and not merely a reaction to some immediate stimulus in the environment. This same reasoning detracts from the importance of external catastrophes—national or international conflicts, financial depressions...Bibliography1. Menninger KA: Man against himself, 1938, Harcourt, Brace and Company, New York. Google Scholar2. RainesThompson GNSV: Suicide, some basic considerations, Digest Neurol. and Psychiat., Inst. of Living 18: 97 (Feb.) 1950. Google Scholar3. Zilboorg G: Differential diagnostic types of suicide, Arch. Neurol. and Psychiat. 35: 270 (Feb.) 1936. CrossrefGoogle Scholar4. Oliver JF: The suicidal risk, New England J. Med. 245: 488, 1951. CrossrefMedlineGoogle Scholar5. Laughlin HP: Suicide, impulse and remorse, Quart. Rev. Psychiat. and Neurol. 166: 19-26 (Jan.) 1953. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Hartford, Connecticut*Received for publication October 11, 1957.Requests for reprints should be addressed to Ludwig M. Frank, M.D., 200 Retreat Avenue, Hartford 2, Connecticut. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byThe “Noncommunicating Suicide”: Does He Exist?Detection and management of the suicidal patientSuicidal behavior in a general hospitalDie Therapie der Manisch-depressiven Erkrankungen 1 September 1958Volume 49, Issue 3Page: 632-641KeywordsAlcoholsComaEmotionsHygieneInsulinReasoningResuscitationSuicide Issue Published: 1 September 1958 PDF downloadLoading ...
Clinical Management of Catecholaminergic Polymorphic Ventricular Tachycardia
Authors: Gaetano M. De Ferrari, Veronica Dusi, Carla Spazzolini, J. Martijn Bos, Dominic J. Abrams, Charles I. Berul, Lia Crotti, Andrew M. Davis, Michael Eldar, Maria Kharlap, Asaad Khoury, Andrew D. Krahn, Antoine Leenhardt, Christopher R. Moir, Attilio Odero, Louise Olde Nordkamp, Thomas Paul, Ferran Rosés i Noguer, Maria Shkolnikova, Jan Till, Arthur A.M. Wilde, Michael J. Ackerman, Peter J. Schwartz
Journal: Circulation (2015)

Background— Catecholaminergic polymorphic ventricular tachycardia (CPVT) is a genetic disorder causing life-threatening arrhythmias whenever sympathetic activity increases. β-Βlockers are the mainstay of therapy; when they fail, implantable cardioverter-defibrillators (ICDs) are used but often cause multiple shocks. Preliminary results with flecainide appear encouraging. We proposed left cardiac sympathetic denervation (LCSD) as useful additional therapy, but evidence remains anecdotal. Methods and Results— We report 63 patients with CPVT who underwent LCSD as secondary (n=54) or primary (n=9) prevention. The median post-LCSD follow-up was 37 months. The 9 asymptomatic patients remained free of major cardiac events. Of the 54 patients with prior major cardiac events either on (n=38) or off (n=16) optimal medical therapy, 13 (24%) had at least 1 recurrence: 0 patients had an aborted cardiac arrest, 2 patients had syncope only, 10 patients had ≥1 appropriate ICD discharges, and 1 patient died suddenly. The 1- and 2-year cumulative event-free survival rates were 87% and 81%. The percentage of patients with major cardiac events despite optimal medical therapy (n=38) was reduced from 100% to 32% ( P &lt;0.001) after LCSD, and among 29 patients with a presurgical ICD, the rate of shocks dropped by 93% from 3.6 to 0.6 shocks per person per year ( P &lt;0.001). Patients with an incomplete LCSD (n=7) were more likely to experience major cardiac events after LCSD (71% versus 17%; P &lt;0.01) than those with a complete LCSD. Conclusions— LCSD is an effective antifibrillatory intervention for patients with CPVT. Whenever syncope occurs despite optimal medical therapy, LCSD could be considered the next step rather than an ICD and could complement ICDs in patients with recurrent shocks.
Marginal overlap between electrocardiographic abnormalities in patients with hypertrophic cardiomyopathy and trained athletes: Implications for preparticipation screening
Authors: Paola Melacini, Cinzia Cianfrocca, Chiara Calore, Francesca Bovolato, Fernando Di Paolo, Filippo Quattrini, Francesco Pelliccia, Sanjay Sharma, William J McKenna, Barry J Maron, Antonio Pelliccia, Domenico Corrado
Journal: Circulation (2007)
THE TREATMENT OF OBESITY WITH AN ANOREXIGENIC DRUG
Authors: E ROBERTS
Journal: Annals of Internal Medicine (1951)

Article1 June 1951THE TREATMENT OF OBESITY WITH AN ANOREXIGENIC DRUGELLA ROBERTS, M.D., F.A.C.P.ELLA ROBERTS, M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-34-6-1324 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptExogenous obesity is a constant problem in medical practice, and often a serious one. According to the Metropolitan Life Insurance Company,1 persons only 15 to 24 per cent overweight have a death rate 44 per cent higher than normal, and for those 25 per cent or more overweight, the death rate shows an increase to 174 per cent. In certain conditions which are frequently characterized by obesity, the statistics are even more appalling. Overweight diabetics, compared with those of normal weight, for example, have a death rate of 257 per cent higher than normal.While a fair number of overweight...Bibliography1. Influence of body weight on mortality; analysis by Metropolitan Life Insurance Company of Union Central Life Insurance Company records, 1887-1921 (chart). Google Scholar2. WilliamsDaughadayRogersAsperTowery RHWHWFSPBT: Obesity and its treatment, with particular reference to the use of anorexigenic compounds, Ann. Int. Med. 29: 510-532, 1948. LinkGoogle Scholar3. GoodmanGilman LA: The pharmacological basis of therapeutics, 1941, The Macmillan Company, New York, p. 442. Google Scholar4. ArnettHarris JHSE: The effects of small doses of amphetamine (benzedrine) sulfate upon the aged, Geriatrics 3: 84-88, 1948. MedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Philadelphia, Pennsylvania*Received for publication July 7, 1949.From the Department of Medicine, Woman's Hospital, Philadelphia, Pennsylvania. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byANOREXIGENIC DRUGS IN PERSPECTIVEThe Storage of Nutrients in the Body, with Particular Reference to Fattening and ObesityThe treatment of obesity: An analysis of methods, results, and factors which influence successDrug and Placebo in Group Treatment of ObesityFettsucht und MagersuchtErnährungstherapie 1 June 1951Volume 34, Issue 6Page: 1324-1330KeywordsDeath ratesDrugsHospital medicineObesityOverweight ePublished: 1 December 2008 Issue Published: 1 June 1951 PDF downloadLoading ...
Alterations Are Ahead at the OAM
Authors: C Marwick
Journal: JAMA (1998)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
End-tidal CO2 pressure decreases during exercise in cardiac patients
Authors: Akihiro Matsumoto, Haruki Itoh, Yoko Eto, Toshio Kobayashi, Makoto Kato, Masao Omata, Hiroshi Watanabe, Kazuzo Kato, Shin-ichi Momomura
Journal: Journal of the American College of Cardiology (2000)
Correlation between intermittent nocturnal hypercapnia and depressive symptoms in patients with obstructive sleep apnea syndrome
Authors: Radoslav Bilyukov, Tsanko Mondeshki, Radostina Cherneva, Daniela Petrova, Ognian Georgiev
Journal: European Respiratory Journal (2011)

Background:  It is still controversial whether sleep disordered breathing could play an independent role in the development of depression. The role of nocturnal hypercapnia is still unclear.It is disputive whether non-invasive ventilation is beneficial.   Materials and methods:  58 patients with OSA participated in our study. OSA was proved using Compumedics polysomnography. The patients were divided into two groups – patients with obesity hypoventilation syndrome (OHS) and OSA; and patients with OSA only. Nocturnal hypercapnia was determined by measurement of end-tidal carbon dioxide (ETCO2) – Nonin Medair. In each group depression was diagnosed using the International Classification of Diseases.criteria. The severity of depressive symptoms was determined using the Zung and Hamilton scales. Patients were on bilevel positive airway pressure therapy and were followed up for 6 months.   Results:  Thirty of the patients (51,7%) had depressive symptoms. There was no correlation between AHI and the severity of depression (p=0.328). The analysis of the hypnogram showed that sleep fragmentation, characterized by arousal index had a significant impact on depressive symptoms (p=0.048, r=0.265). Another important factor that determines daytime affective status was nocturnal hypercapnea (p=0,05, r=0,265). Body mass index (BMI) also showed a statistically significant relationship with the depressive symptoms (p=0.006, r=0.368).   Conclusion:  The degree of OSA determined by AHI and the desaturation index do not contribute to the development of depressive symptoms in patients with OHS/OSA. BMI, sleep fragmentation, nocturnal hypercapnea are of greater importance.
Abstract 10358: Radial versus Femoral Approach in Non-ST Elevation ACS: Lessons From EARLY
Authors: Marc W Klutstein, Cynthia M Westerhout, Sunil Rao, Basil S Lewis, C Michael Gibson, Sohrab Lutchmedial, Petr Widimsky, P Gabriel Steg, Anthony Dalby, Uwe Zeymer, Frans Van de Werf, Robert A Harrington, L Kristin Newby, Paul W Armstrong
Journal: Circulation (2010)

Background: EARLY-ACS patients (pts) with non-ST elevation acute coronary syndromes (NSTEACS) were randomized to early vs delayed provisional eptifibatide: pts subsequently underwent an invasive st...
Spatial genomic heterogeneity within localized, multifocal prostate cancer
Authors: Paul C Boutros, Michael Fraser, Nicholas J Harding, Richard de Borja, Dominique Trudel, Emilie Lalonde, Alice Meng, Pablo H Hennings-Yeomans, Andrew McPherson, Veronica Y Sabelnykova, Amin Zia, Natalie S Fox, Julie Livingstone, Yu-Jia Shiah, Jianxin Wang, Timothy A Beck, Cherry L Have, Taryne Chong, Michelle Sam, Jeremy Johns, Lee Timms, Nicholas Buchner, Ada Wong, John D Watson, Trent T Simmons, Christine P'ng, Gaetano Zafarana, Francis Nguyen, Xuemei Luo, Kenneth C Chu, Stephenie D Prokopec, Jenna Sykes, Alan Dal Pra, Alejandro Berlin, Andrew Brown, Michelle A Chan-Seng-Yue, Fouad Yousif, Robert E Denroche, Lauren C Chong, Gregory M Chen, Esther Jung, Clement Fung, Maud H W Starmans, Hanbo Chen, Shaylan K Govind, James Hawley, Alister D'Costa, Melania Pintilie, Daryl Waggott, Faraz Hach, Philippe Lambin, Lakshmi B Muthuswamy, Colin Cooper, Rosalind Eeles, David Neal, Bernard Tetu, Cenk Sahinalp, Lincoln D Stein, Neil Fleshner, Sohrab P Shah, Colin C Collins, Thomas J Hudson, John D McPherson, Theodorus van der Kwast, Robert G Bristow
Journal: Nature Genetics (2015)
Lab-on-a-Chip Shows Promise in Defining and Diagnosing Cancers
Authors: J Stephenson
Journal: JAMA (1999)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Causes of Death for Patients With Community-Acquired Pneumonia—Reply
Authors: Eric Mortensen, D. Scott Obrosky, Michael J. Fine
Journal: JAMA Internal Medicine (2002)

Methods: For all deaths within 90 days of presentation, a synopsis of all events preceding death was independently reviewed by 2 members of a 5-member review panel (C.M.C., D.E.S., T.J.M., W.N.K., and M.J.F.). The underlying and immediate causes of death and whether pneumonia had a major, a minor, or no apparent role in the death were determined using consensus. Death was defined as pneumonia related if pneumonia was the underlying or immediate cause of death or played a major role in the cause of death. Competing-risk Cox proportional hazards regression models were used to identify baseline characteristics associated with mortality.
Decline of U.S. medical student career choice of psychiatry and what to do about it
Authors: F S Sierles, M A Taylor
Journal: American Journal of Psychiatry (1995)

In 1994, only 3.2% of U.S. medical school graduates chose psychiatry, the lowest proportion since 1929. Success in recruiting such graduates is necessary to maintain adequate numbers of psychiatrists. The authors' goal was to gain an understanding of the determinants of specialty selection to ensure adequate recruitment.They reviewed all recruitment-related English-language publications since 1959: 173 papers, 17 reports, and 10 books.They found that recruitment has been cyclical, with success from 1940 to 1969 and from 1985 to 1988, decline from 1970 to 1984 and from 1989 to 1994, and a possible small upswing in 1995. The 1940-1969 success began with 1) public recognition of a dramatic shortage of psychiatrists to serve in the military and treat casualties and 2) the fervor of the community mental health movement, which promised to prevent mental illness; massive resources were provided for psychiatry during this period. The declines were associated with 1) the failure of the community mental health movement to fulfill its promise, 2) psychiatry's becoming more biologically oriented and medically conventional, and 3) the effects of managed care and increased competition for patients. The psychiatry departments that have high recruitment rates are in public-supported schools, particularly in the South, or give considerable priority and resources for medical student psychiatric education.A study of the psychiatric workforce is needed to ascertain whether there is a surplus or a shortage of psychiatrists. Regardless, to ensure adequate recruitment, medical institutions and departments of psychiatry must commit resources for student education in psychiatry.