tbuckley/cabot-search huggingface dataset:
THE ECONOMIC PRODUCTION AND DISTRIBUTION OF CLEAN MILK.
Authors: JOSEPH ROBY
Journal: JAMA (1906)

An editorial inThe Journalof the American Medical Association December 9 states: "The question as to whether milk is better food for children in a raw or Pasteurized state is easily answered in a few cities where supervision of dairies is properly carried out and the standard of dairy cleanliness high. Under such circumstances, there is no question that the raw material is the best in every way.... The conduct of a clean modern dairy requires a large outlay of buildings and apparatus and a much larger force of helpers than is to be found in the average dairy of the present. In order to procure clean milk in our cities, therefore, we must either raise the price of milk or resort to some artificial method of rendering it innocuous. Unfortunately, any increase in the price of milk would fall most heavily on the more prolific poorer classes, and
Inactivation of Macrophage Scavenger Receptor Class B Type I Promotes Atherosclerotic Lesion Development in Apolipoprotein E–Deficient Mice
Authors: Wenwu Zhang, Patricia G. Yancey, Yan Ru Su, Vladimir R. Babaev, Yuomin Zhang, Sergio Fazio, MacRae F. Linton
Journal: Circulation (2003)

Scavenger receptor class B type I (SR-BI) is expressed in macrophages, where it has been proposed to facilitate cholesterol efflux. However, direct evidence that the expression of macrophage SR-BI is protective against atherosclerosis is lacking. In this study, we examined the in vivo role of macrophage SR-BI in atherosclerotic lesion development in the apolipoprotein (apo) E-deficient mouse model.ApoE-deficient mice with (n=16) or without (n=15) expression of macrophage SR-BI were created by transplanting lethally irradiated apoE-deficient mice with bone marrow cells collected from SR-BI-/- apoE-/- mice or SR-BI+/+ apoE-/- mice. The recipient mice were fed a chow diet for 12 weeks after transplantation for analysis of atherosclerosis. Quantification of macrophage SR-BI mRNA by real-time reverse transcription-polymerase chain reaction indicated successful engraftment of donor bone marrow and inactivation of macrophage SR-BI in recipient mice reconstituted with SR-BI-/- apoE-/- bone marrow. There were no significant differences in plasma lipid levels, lipoprotein distributions, and HDL subpopulations between the 2 groups. Analysis of the proximal aorta demonstrated an 86% increase in mean atherosclerotic lesion area in SR-BI-/- apoE-/- --> apoE-/- mice compared with SR-BI+/+ apoE-/- --> apoE-/- mice (109.50+/-18.08 versus 58.75+/-9.58x10(3) microm2; mean+/-SEM, P=0.017). No difference in cholesterol efflux from SR-BI+/+ apoE-/- or SR-BI-/- apoE-/- macrophages to HDL or apoA-I discs was detected.Expression of macrophage SR-BI protects mice against atherosclerotic lesion development in apoE-deficient mice in vivo without influencing plasma lipids, HDL subpopulations, or cholesterol efflux. Thus, macrophage SR-BI plays an antiatherogenic role in vivo, providing a new therapeutic target for the design of strategies to prevent and treat atherosclerosis.
Tissue concentration of clindamycin and gentamicin near ischaemic ulcers with transvenous injection in Bier's arterial arrest
Authors: Heinz Burgmann, Apostolos Georgopoulos, Wolfgang Graninger, Renate Koppensteiner, Thomas Maca, Erich Minar, Barbara Schneider, Andreas Stümpflen, Herbert Ehringer
Journal: The Lancet (1996)
Peripheral blood lymphocytes with receptors for a determinant common to B‐lymphoblastoid cell lines and acute myelogenous leukemia blasts
Authors: Alan Lichtenstein, Faramarz Naiem, Jacob Zighelboim
Journal: American Journal of Hematology (1984)

Abstract We investigated whether the rosetting of B‐lymphoblastoid cell lines (B‐LCL) by peripheral blood lymphocytes (PBLs) reflected possible interactions between lymphoid cells and immature cells of the hematopoietic system. Rosette formation could be blocked by the addition of soluble antigen extracted from B‐LCL or blasts obtained from patients with acute myelogenous leukemia (AML). This inhibition was specific for AML blasts (similarly extracted material from melanoma lines had no inhibitory effect) and for the B‐LCL receptor (leukemic extracts had no effect on surface receptors for sheep red blood cells (E) or antibody‐sensitized red blood cells (EA)). The B‐LCL receptor is present on leukemic Sezary T‐cells as well as normal T‐cells and its sensitivity to various enzymatic treatments is markedly different from that of E and EA receptors. In addition, B‐LCLs derived from in vitro EB‐viral infection of a normal donor's B lymphocytes were significantly rosetted by that donor's autologous PBLs. These data suggest the B‐LCL receptor, present on mature T‐cells, can recognize self determinants on myeloblasts and B‐LCL. Further investigation will determine whether this interaction can affect the function of rosetted target cells.
Remarks ON THE RATIONAL TREATMENT OF FUNCTIONAL DYSPEPSIA
Authors: R. Hutchison
Journal: BMJ (1908)

TRRATMENT OF FUNCTIONAL DYSPEPSIA. [AL 11, 1vS splint was applied to the limb still in the elevated posi- tion, and the same attitude was maintained as the patient was removed to. the ward, and continued by attaching the end of the splint to a rope connected with the tripod and pulley used in applying Sayre's plaster of Paris jacket.This position of the limb did not cause the patient material inconvenience, and after two or three days the rope was slackened a little so as to allow the end of the splint to come down an inch or two, and the same thing was repeated every two days or so, till the limb could be placed quite horizontal.This preliminary operation has taken a long time to describe; but in execution it is of the simpleat character, no paring of the broken surfaces being done at this stage, and there being almost no bleeding and no shock.The wound having healed (I need hardly say without suppura- tion), the patient was allowed to leave her bed, and left the hospital soon after to practise using the limb.Before long she was readmitted, and the second opera.tion was performed.The lower cicatrix was opened and the wire removed, and two interrupted wire sutures placed in the tracks of the previous continued one; the frag- ments, ol course, being this time pared to clear them of fibrous tissue of new formation, and produce smooth sur- faces for coaptation.This was all satisfactorily effected, though not without the use of the powerful hook and the vertical position of the limb.The result was restoration of the use of the joint in a manner so satisfactory that I determined to try the same procedure in the other limb.The only difference which I made in this case was that, as the upper fragment was too small to bear drilling, I passed the ends of the wire, in dealing with that fragment, through the tendon of the quadriceps just above .the.upperborder of the bone, the lower fragment, which was, of course, very substantial, being drilled as In the other limb.By. this means, alded
[268] RESECTION VS RADIOFREQUENCY ABLATION FOR HCC FROM 3 TO 5cm: A SINGLE CENTRE EXPERIENCE ON 101 CHILD-PUGH CLASS A-B NAIVE PATIENTS
Authors: L. Lupo, P. Panzera, G. Carbotta, A. Gentile, A. Gallerani, M. Stefano, V. Memeo
Journal: Journal of Hepatology (2007)
Histology: An Interactive Virtual Microscope
Authors: Michael J. Kornstein
Journal: JAMA (2003)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
PAPILLOMA OF THE CORNEA, WITH REPORT OF A CASE.Read in the Section of Ophthalmology, at the Forty-second Annual Meeting of the American Medical Association, held at Washington, D. C., May, 1891.
Authors: S. C. AYRES
Journal: JAMA (1891)

It sounds somewhat contradictory to say that a papilloma can develop from a surface which is not naturally supplied with papillae. At first it would seem impossible, but the vagaries of neoplasms are numerous, and this seems to be one of them. Von Ziemssen, in<i>Ziemssen's Archives</i>, Vol. vii, in speaking of papillÆ of the larynx, says: "The development of papillary growths occurs not only off the mucous surface originally provided with papillÆ, but, as is especially shown by Virchow (Krankhafte Geschwulste, 1, pp 334 and following), also in regions where papillary structure of the mucous membrane is entirely lacking. The first step is the proliferation of the superficial connective tissue, the development of a little amorphous granular or homogeneous nodule, in which cells are not to be recognized until later. As the cells multiply, they gradually grow and put forth buds, just as is done by the preëxisting papillae
Inhibition of Diet-Induced Atherosclerosis and Endothelial Dysfunction in Apolipoprotein E/Angiotensin II Type 1A Receptor Double-Knockout Mice
Authors: Sven Wassmann, Thomas Czech, Martin van Eickels, Ingrid Fleming, Michael Böhm, Georg Nickenig
Journal: Circulation (2004)

Background— Angiotensin II type 1 (AT1) receptor activation is potentially involved in the multifactorial pathogenesis of atherosclerosis. Methods and Results— Apolipoprotein E–deficient (ApoE −/− ) mice were crossed with AT1A receptor–deficient (AT1 −/− ) mice to obtain homozygous double-knockout animals (ApoE −/− -AT1 −/− mice). Wild-type (C57BL/6J), ApoE −/− , AT1 −/− , and ApoE −/− -AT1 −/− mice were fed a high-cholesterol diet for 7 weeks. In contrast to wild-type and AT1 −/− mice, this treatment led to severe atherosclerotic lesion formation in the aortic sinus and the aorta (oil red O staining) and to an impaired endothelium-dependent vasodilation (organ chamber experiments with isolated aortic segments) in ApoE −/− mice. In the age-matched ApoE −/− -AT1 −/− littermates, development of diet-induced endothelial dysfunction and atherosclerotic lesion formation was profoundly inhibited. Concomitantly, aortic release of superoxide radicals was increased 2-fold in ApoE −/− mice compared with wild-type animals, whereas aortic superoxide production was normalized in ApoE −/− -AT1 −/− mice (L-012 chemiluminescence). There were no significant differences in plasma cholesterol levels between ApoE −/− and ApoE −/− -AT1 −/− animals. Systolic blood pressure was significantly lower in ApoE −/− -AT1 −/− animals than in ApoE −/− mice (tail-cuff measurements). Oral treatment of ApoE −/− mice with either hydralazine or irbesartan reduced systolic blood pressure to the same level; however, only AT1 receptor antagonist treatment reduced atherosclerotic lesion formation and improved endothelial function. Conclusions— Genetic disruption of the AT1A receptor leads to inhibition of vascular oxidative stress, endothelial dysfunction, and atherosclerotic lesion formation in ApoE −/− mice irrespective of blood pressure and plasma cholesterol levels. These results indicate a fundamental role of AT1 receptor activation in atherogenesis.
813-4 Smooth muscle cell proliferation index correlates with indium-111 Z2D3 antibody uptake in a transplant vasculopathy swine model
Authors: Javier Jimenez, Dillip Sawatt, Tammy Donahay, Lorraine Schofield, Ban An Khaw, Lynne L Johnson
Journal: Journal of the American College of Cardiology (2004)
Lumiracoxib inhibits cyclo-oxygenase 2 completely at the 50 mg dose: is liver toxicity avoidable by adequate dosing?
Authors: B Hinz, B Renner, O Cheremina, D Besz, O Zolk, K Brune
Journal: Annals of the Rheumatic Diseases (2009)

Lumiracoxib is a selective cyclo-oxygenase 2 (COX-2) inhibitor used for symptomatic treatment of osteoarthritis and acute pain. Among the available COX-2 inhibitors, lumiracoxib is the only compound with gastrointestinal benefit in patients with osteoarthritis that has been demonstrated in a large outcome study.1

Several countries have approved lumiracoxib at doses of 200 mg (for osteoarthritis) and 400 mg (for acute pain), both of them exceeding the dose necessary to inhibit COX-2 at the time of maximal plasma concentration.2 In line with this notion, one clinical trial reported that patients with knee or hip osteoarthritis randomised to receive lumiracoxib at 50, 100 or 200 mg twice daily or at 400 mg once daily experienced a comparable pain relief.3 Regrettably, a systematical analysis of dose-dependent therapeutic effects of lumiracoxib is lacking.

The interest in …
SERIAL GREY-SCALE AND RADIOFREQUENCY INTRAVASCULAR ASSESSMENT OF PLAQUE MODIFICATION AND VESSEL GEOMETRY AT PROXIMAL AND DISTAL EDGES OF BARE-METAL AND DRUG-ELUTING STENTS
Authors: Jos&eacute; de Ribamar Costa, Dimytri Siqueira, Alexandre Abizaid, Daniel Chamie, Ricardo Costa, Renata Viana, Fausto Feres, Amanda Sousa, J. Eduardo Sousa
Journal: Journal of the American College of Cardiology (2012)
Screening Reagent for Hemoglobin S (Hb S)
Authors: Hans N. Naumann
Journal: JAMA (1974)

<h3>To the Editor.—</h3> Numerous screening modifications of the phosphate solubility test for hemoglobin S (Hb S) have been described (US Patent No. 3,492,095, 1970;<i>J Clin Pathol</i>23:781, 1970 and 24:91, 1971;<i>Am J Clin Pathol</i>58:11, 1971 and 59:300, 1973;<i>Clin Chem</i>17:1028 and 1087, 1971;<i>Summary Reports, ASCP</i>, vol 8, August 1971;<i>N Engl J Med</i>286:1143, 1972). All the reagents contain varying proportions of potassium phosphate buffer (KH<sub>2</sub>PO<sub>4</sub>and K<sub>2</sub>HPO<sub>4</sub>), saponin (lysing agent), and sodium dithionite (Na<sub>2</sub>S<sub>2</sub>O<sub>4</sub>, reducing agent). All are based on Itano's principle (1953) that 2.24 M phosphate selectively precipitates reduced Hb S. Yet, no adequate directions have so far been given for preparation and avoidance of pitfalls. Difficulties of preparation include (1) absorption of moisture from the air by K<sub>2</sub>HPO<sub>4</sub>, causing weighing errors, transition to pyrophosphate on heating, and formation
Effect of atherosclerosis on the responsiveness of the rapidly acting arterial pressure control system in WHHL rabbits
Authors: Hiroshi Hosomi, Shinichiro Katsuda, Yoshio Watanabe
Journal: Cardiovascular Research (1986)

The open loop gain of the rapidly acting arterial pressure control system was estimated in 15 Watanabe heritable hyperlipidaemic (WHHL) rabbits aged 3-31 months. Twenty five normal Japanese white rabbits, aged 6-30 months, were used as controls. After being anaesthetised by an intravenous injection of pentobarbital sodium, the rabbits were bled by 2 ml·kg−1 body weight within 1-2 s through a catheter inserted into the aortic arch. The arterial pressure change after this rapid haemorrhage was recorded for more than 2 min by a catheter placed in the aortic arch. The open loop gain was calculated as (Δ API/Δ APS)−1, where Δ API was the immediate fall and Δ APS the steady state fall. The pulse pressure, Δ API, and Δ APS increased and the open loop gain decreased with age in the WHHL rabbits, but the mean arterial pressure did not change significantly with age. After aortic denervation the open loop gain also decreased with age in the WHHL rabbits. These results indicate that the progress of atherosclerosis with aging in the Watanabe heritable hyperlipidaemic rabbit decreases the vascular compliance and impairs the arterial pressure restoring function of the rapidly acting arterial pressure control system.
(7) Anhidrotic ectodermal dysplasia
Authors: Sarah C.F. Rogers
Journal: British Journal of Dermatology (1984)

Journal Article (7) Anhidrotic ectodermal dysplasia Get access Sarah C.F. Rogers Sarah C.F. Rogers City of Dublin Skin and Cancer Hospital, Dublin Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 111, Issue s26, 1 July 1984, Pages 51–52, https://doi.org/10.1111/j.1365-2133.1984.tb05277.x Published: 01 July 1984
Altering Triglyceride Concentrations Changes Insulin-Glucose Relationships in Hypertriglyceridemic Patients: Double-Blind Study With Gemfibrozil With Implications for Atherosclerosis
Authors: George Steiner
Journal: Diabetes Care (1991)

To determine whether reducing triglyceride concentrations in humans reduces serum insulin levels and consider the implications of this for the insulin resistance of hypertriglyceridemia.Insulin and glucose levels were determined during an oral glucose tolerance test (OGTT) in 14 volunteers who had a range of basal triglyceride levels. A double-blind crossover design was used to study active and placebo gemfibrozil and relate triglyceride changes to insulin and glucose levels. Diet and weight were kept constant.Glucose concentrations during OGTT were the same in both treatment periods. Insulin concentrations were reduced in proportion to reductions in triglyceride.Triglyceride reduction in hypertriglyceridemic patients is associated with a decrease in serum insulin. This does not appear to be a direct effect of gemfibrozil, because it does not occur without a sufficient fall in triglyceride levels. Because glucose concentration remains the same despite the reduced insulin, the triglyceride reduction may result in greater sensitivity to insulin. Treatment of hypertriglyceridemia may break a vicious and potentially atherogenic cycle of hypertriglyceridemia and hyperinsulinemia.
Solute transfer into the extravascular space: comparison of two non-invasive measurement techniques
Authors: A M PETERS, M J MYERS
Journal: Cardiovascular Research (1989)

Journal Article Solute transfer into the extravascular space: comparison of two non-invasive measurement techniques Get access A M PETERS, A M PETERS Address for correspondence and reprints: Dr A M Peters, Department of Radiology, Hammersmith Hospital, Du Cane Road, London W12 0HS Search for other works by this author on: Oxford Academic PubMed Google Scholar M J MYERS M J MYERS **From the Department of Medical Physics, Hammersmith Hospital, London Search for other works by this author on: Oxford Academic PubMed Google Scholar Cardiovascular Research, Volume 23, Issue 7, July 1989, Pages 639–646, https://doi.org/10.1093/cvr/23.7.639 Published: 01 July 1989 Article history Accepted: 08 March 1989 Published: 01 July 1989
Schönlein-Henoch Purpura Misdiagnosed as Suspected Child Abuse
Authors: Jeffrey Brown
Journal: JAMA (1986)

IN 1962, Kempe and his associates<sup>1</sup>published their classic work, "The Battered Child Syndrome," inThe Journal. Since then, the awareness and sensitivity of both the medical profession and lay community to the problem of child abuse have increased. Every year, more than 1 million children in the United States are seriously abused by their parents, guardians, or others, and between 2000 and 5000 children die as a result of their injuries.<sup>2,3</sup> Cutaneous lesions are, by far, the most common presenting physical findings of child abuse.<sup>4</sup>Several articles and reviews,<sup>4-7</sup>including diagnostic guidelines recently published in<i>JAMA</i>,<sup>8</sup>have documented the most common manifestations of lesions that result from nonaccidental trauma and injury. Unfortunately, typical or atypical presentations of skin disorders, not resulting from trauma or injury, can be misdiagnosed as suspected child abuse. We report a case as an example. <h3>Report of a Case</h3> An
Inclusion of Rhinovirus Wheezing History in Early Life Improves the Sensitivity of the Modified Asthma Predictive Index (mAPI)
Authors: D.J. Jackson, T.W. Guilbert, M.D. Evans, R.E. Gangnon, K.A. Roberg, E.L. Anderson, T.E. Pappas, C.J. Tisler, D.F. DaSilva, L.E.P. Salazar
Journal: Journal of Allergy and Clinical Immunology (2009)
The α1-adrenoceptor profile in human skeletal muscle resistance arteries in critical limb ischaemia
Authors: Yagna P R Jarajapu, John C McGrath, Chris Hillier, Allan MacDonald
Journal: Cardiovascular Research (2003)

Objective: We recently reported the hyper-responsiveness of human skeletal muscle resistance arteries (SkMRAs) to noradrenaline in critical limb ischaemia (CLI). In this study we investigated the characteristics of α1-adrenoceptor subtypes and evaluated the agonist affinity and adrenoceptor reserve in the ischaemic arteries. Methods: Human SkMRAs were isolated from non-ischaemic and ischaemic areas of limbs amputated for CLI. Subcutaneous resistance arteries were isolated from inguinal biopsies from healthy subjects. Arterial segments were mounted on a small vessel wire myograph. Results: Contractile responses to agonists, adrenaline and A-61603 (α1A-selective) were significantly increased in ischaemic arteries compared to those in non-ischaemic arteries. Receptor inactivation studies indicated an increase in the α-adrenoceptor reserve in the ischaemic arteries but the affinity of noradrenaline was unaffected. Healthy subcutaneous arteries had a similar noradrenaline affinity but a higher receptor reserve than skeletal muscle arteries. In the ischaemic arteries, the antagonists prazosin (α1-selective), 5-methyl-urapidil (α1A-selective) and BMY 7378 (α1D-selective) produced rightward shifts in the concentration response curves (CRCs) of noradrenaline giving pKBs of 9.6±0.3, 8.4±0.2 and 7.1±0.4, respectively. Pretreatment with 10 μM chloroethylclonidine decreased the contractile responses to noradrenaline and A-61603 to 57±7 and 72±4% of their respective controls. Conclusions: These results demonstrate that the ischaemic SkMRAs have an increased α-adrenoceptor reserve with no change in the predominant α1A-adrenoceptor profile.
Severe congenital Factor VII deficiency associated with the 13q deletion syndrome
Authors: Michael P. Hewson, John M. Carter
Journal: American Journal of Hematology (2002)

Abstract The first reported case of clinically significant congenital Factor VII deficiency in association with the 13q deletion syndrome is presented. It illustrates the importance of knowledge of the specific genes involved in gross deletion syndromes and adds to the current clinical experience of this rare disease. Am. J. Hematol. 71:232–233, 2002. © 2002 Wiley‐Liss, Inc.