FACTORS CONTROLLING HEMOPOIESIS: EXPERIMENTAL OBSERVATIONS ON THEIR ROLE IN POLYCYTHEMIA VERA
Authors: J W LINMAN, F H BETHELL, M J LONG
Journal: Annals of Internal Medicine (1959)

Article1 November 1959FACTORS CONTROLLING HEMOPOIESIS: EXPERIMENTAL OBSERVATIONS ON THEIR ROLE IN POLYCYTHEMIA VERAJAMES W. LINMAN, M.D., FRANK H. BETHELL, M.D., F.A.C.P., MARTHA J. LONG, M.S.JAMES W. LINMAN, M.D.Search for more papers by this author, FRANK H. BETHELL, M.D., F.A.C.P.Search for more papers by this author, MARTHA J. LONG, M.S.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-51-5-1003 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptIt has long been evident that erythropoiesis is governed by equilibrated forces which maintain the normal erythroid steady state and determine erythropoietic responses to stimuli arising from physiologic and pathologic changes. Until recently, however, little was known concerning the manner by which erythrocytic equilibrium was maintained or restored. During the last few years, studies in many laboratories have established the existence of a humoral erythropoietic regulatory mechanism,1, 2 and evidence is now available which suggests that the formation of other hemic elements may be subject to similar controlling factors.Our previous studies3-5indicate that two humoral factors exert control over...Bibliography1. Sacks MS: Erythropoietin, Editorial, Ann. Int. Med. 48: 207-212, 1958. LinkGoogle Scholar2. Gordon AS: Hemopoietine, Physiol. Rev. 39: 1-40, 1959. CrossrefMedlineGoogle Scholar3. BethellLinmanKorst FHJWDR: Erythropoietic activity of "anemic" and "polycythemic" plasmas, Tr. A. Am. Physicians 70: 297-304, 1957. MedlineGoogle Scholar4. LinmanBethellLong JWFHMJ: Studies on the nature of the plasma erythropoietic factor(s), J. Lab. and Clin. Med. 51: 8-16, 1958. MedlineGoogle Scholar5. LinmanKorstBethell JWDRFH: Some observations on the stimulation of erythropoiesis by humoral factors, Ann. New York Acad. Sc. 77: 638-649, 1959. 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Author, Article, and Disclosure InformationAffiliations: *Received for publication July 6, 1959.Presented at the Fortieth Annual Session of The American College of Physicians, Chicago, Illinois, April 20, 1959.From the Department of Medicine, Northwestern University Medical School, and the Veterans Administration Research Hospital, Chicago, Illinois; and the Department of Internal Medicine and the Simpson Memorial Institute for Medical Research, University of Michigan, Ann Arbor, Michigan.Aided by Research Grant No. A-1991 from the National Institutes of Health, U. S. Public Health Service.†Deceased.Requests for reprints should be addressed to James W. Linman, M.D., Veterans Administration Research Hospital, 333 East Huron, Chicago 11, Illinois. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byPathogenesis of polycythemia vera—new conceptsDie humorale und nervöse Regelung der ErythropoesePolyglobulie und Polycythaemia veraBIBLIOGRAPHYTissue culture of bone marrow.III. Myelostimulatory factors in serum of patients with myeloproliferative diseasesPolycythaemia and Nephropathias in Diabetic and Hypertensive PatientsPolycythemiaStudies on thrombopoiesisNephrogenic ErythrocytosisA blood culture method of quantitative estimation of hemopoietinsErythrocythemia and Neoplastic TumorsROBERT M. DONATI, M.D., JOHN M. MCCARTHY, M.D., ROBERT D. LANGE, M.D., F.A.C.P., NEIL I. GALLAGHER, M.D.ErythrocythemiaPolycythaemia veraROLE OF THE ERYTHROPOIETIC HORMONEEffect of polycythemia on gastric secretionOBSERVATIONS ON ERYTHROPOIETIC-STIMULATING FACTOR (ESF) IN THE PLASMA OF UREMIC AND NONUREMIC ANEMIC PATIENTS*†N. I. GALLAGHER, M.D., J. M. MCCARTHY, M.D., R. D. LANGE, M.D., F.A.C.P.Red-cell RegulatorsHUMAN RELATIONS IN OBSTETRIC PRACTICERED-CELL REGULATORS 1 November 1959Volume 51, Issue 5Page: 1003-1018KeywordsAlcoholsBlood plasmaHemoglobinHospital medicineHypoxiaPolycythemiaPolycythemia veraPrevention, policy, and public healthResearch grantsThrombocytosis ePublished: 1 December 2008 Issue Published: 1 November 1959 PDF downloadLoading ...