tbuckley/cabot-search huggingface dataset:
Hyponatraemia during carbamazepine treatment.
Authors: D A Henry, D H Lawson, P Reavey, S Renfrew
Journal: BMJ (1977)

<h3>Background:</h3> Literature suggests that early patterns of aggressive behaviour in both girls and boys are predictive of a variety of health risks in adulthood. However, longitudinal examination of the predictive links between childhood aggression, negative physical health outcomes in adulthood and overall use of health care has not been done. We looked at use of health care and a variety of physical health outcomes in adulthood to extend the current body of knowledge regarding the long-term negative sequelae of childhood aggression. <h3>Methods:</h3> Participants of the Concordia Longitudinal Risk Project were eligible for the current study if they had received medical care in the province of Quebec between 1992 and 2006, and if we were able to retrieve their medical and education records. Our primary outcome was use of the health care system, as determined using records from the Régie de l'assurance maladie du Québec and the Ministère de la santé et des services sociaux. Our controlled variables were socioeconomic status of the neighbourhood in which participants lived in 1986 and level of education. We used hierarchical multiple regression to explore the association between childhood behaviour and physical health in adulthood. <h3>Results:</h3> During the 15-year period studied, childhood agression corresponded to an increase in medical visits (8.1% per 1 standard deviation increase in agression), and injuries (10.7%) or lifestyle-related illnesses (44.2%), visits to specialists (6.2%) and visits to emergency departments (12.4%). We saw a positive relation between social withdrawal during childhood and government-funded visits to dentists. Peer-rated likeability during childhood showed negative relations with use of health care (overall), medical visits due to injuries and government-funded visits to dentists. <h3>Interpretation:</h3> Childhood aggression is a health risk that should be considered when designing interventions to improve public health and diminish the costs of medical services, particularly when considering interventions targeting children and families.
Eliciting antigenicities of benzylpenicillin, ampicillin and carbenicillin preparations examined with the reagin-mediated passive cutaneous anaphylaxis system Igarashi, H., Koizumi, K., and Muranaka, M.: Int. Arch. Allergy Appl. Immunol. 57:341, 1978
Authors: None BS
Journal: Journal of Allergy and Clinical Immunology (1978)
Diagnostic Errors and Patient Safety
Authors: Jennifer S. Myers
Journal: JAMA (2009)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
A case of linear scleroderma with muscle calcification
Authors: M. Jinnin, H. Ihn, Y. Asano, K. Yamane, N. Yazawa, K. Tamaki
Journal: British Journal of Dermatology (2002)

Summary We report a 21-year-old man with linear scleroderma with muscle calcification revealed by a computed tomographic (CT) scan. Levels of serum calcium and phosphorus were normal. This is the first report of localized scleroderma with muscle calcification. Muscle involvement may cause contracture or functional abnormalities of the extremities. Therefore, CT scans may be useful in evaluating muscle involvement in patients with localized scleroderma.
"Acquired" Agammaglobulinemia with Defective Delayed Hypersensitivity
Authors: WILLIAM L. KOPP
Journal: Annals of Internal Medicine (1968)

An adult man with recurrent bacterial infections, joint symptoms, and diarrhea had unusually severe immunologic deficiency and clinical and histologic evidence of both rheumatoid arthritis and ulcerative colitis. Studies revealed absent immune globulins, defective delayed hypersensitivity, and low lymphocyte counts. He rejected an allograft gradually over a 2-month period while he took 15 mg of prednisone daily for colitis. In tissue culture his lymphocytes did not proliferate with phytohemagglutinin or with antigens, although they responded to allogeneic cells. At necropsy, only microscopic remnants of thymus were found. The patient's illness, therefore, had characteristics of both "acquired" and lymphopenic agammaglobulinemia.
In vivo assessment of left ventricular remodelling after myocardial infarction by digital video contrast angiography in the rat
Authors: S. Ono, V. Bhargava, S. Ono, L. Mao, G. Hagan, H. A Rockman, J. Ross
Journal: Cardiovascular Research (1994)

Objective: The aim was to develop a digital video contrast angiographic method for assessing global left ventricular function and volume in vivo in the rat and then to apply it to a study of ventricular remodelling after coronary occlusion, with and without reperfusion. Methods: Digital contrast angiography was performed on 29 rats, including the following groups: sham operated (n=11), non-transmural myocardial infarction produced by reperfusion (n = 8), and transmural infarction produced by permanent occlusion (n= 10). Under anaesthesia three weeks later, biplane fluoroscopic images were acquired following venous contrast injection. Levophase images were digitised, and left ventricular end diastolic and end systolic volumes and ejection fractions were obtained using an area-length method. Left ventricular ejection fraction data also were calculated by videodensitometry from video density curves. Results: Compared to the sham operated group, the reperfused group showed a significant decrease in left ventricular ejection fraction, at 53(SD 7) v 70(5)% (p<0.01), and an increase in end diastolic volume. The permanent occlusion group showed a further decrease in the ejection fraction [40(8)%] and a further significant increase in end diastolic volume compared to the reperfused group (p<0.01). Left ventricular ejection fraction correlated inversely with percent infarct size (r = 0.882) and showed a positive correlation with the spared epicardial area (r = 0.721). Most haemodynamic variables, including maximum left ventricular dP/dt, failed to discriminate between the groups. The methods showed reasonable accuracy when tested in vitro using contrast filled balloons. In vivo, the left ventricular ejection fraction calculated by densitometry showed adequate interobserver variability (2 SD ± 8.5 percentage points), but the area-length method showed somewhat more scatter. Conclusions: Digital video contrast angiography is a feasible method for the assessing global left ventricular function in the rat and should be useful in other small animal models. Significant differences in left ventricular volumes and ejection fractions were detected between reperfused and permanent occlusion groups, whereas haemodynamic variables showed non-significant trends. Reperfusion after 45 min of occlusion caused sparing of the epicardium, prevented unfavourable remodelling, and improved the ejection fraction compared to permanent occlusion. Cardiovascular Research 1994;28:349-357
Endemic Pleural Calcification and Mesothelioma
Authors: A. M. Langer
Journal: JAMA (1988)

To the Editor.—  A recent case report by Sichletidis et al1and a letter on the case by Dr Germine2merit comment. In 1985, we reported the occurrence of endemic pleural calcification and mesothelioma in northwestern Greece.3Although an earlier report had described widespread pleural calcification observed during a tuberculosis survey in the region, we found that mesothelioma had occurred as well.3No occupational or infectious agent could be found to explain this pattern, referred to asMetsovo lung.  The number of pleural mesotheliomas observed, five among 5000 people in two years, was striking considering there was no commercial asbestos industry within 80 km of the area. We reported that asbestiform tremolite was found in five of the eight transbronchial biopsy specimens obtained from people with Metsovo lung. We suggested that this was the agent responsible for both Metsovo lung and the pleural mesotheliomas, although the
Argon Plasma Coagulation in Flexible Gastrointestinal Endoscopy: Pilot Experiences
Authors: P. J. Wahab, C. J. J. Mulder, G. den Hartog, J. E. Thies
Journal: Endoscopy (1997)

Background and Study Aims: In argon plasma coagulation (APC), high-frequency energy is transmitted to tissue by ionized gas, thus reducing contact with the tissue to a minimum. Successful endoscopic APC was initially reported in the palliative treatment of gastrointestinal neoplasms. The main objectives in this pilot study were to evaluate the treatment indications, efficacy and safety of the use of APC.
Serum dioxin concentrations and breast cancer risk in the Seveso Women's Health Study.
Authors: Marcella Warner, Brenda Eskenazi, Paolo Mocarelli, Pier Mario Gerthoux, Steven Samuels, Larry Needham, Donald Patterson, Paolo Brambilla
Journal: Environmental Health Perspectives (2002)

2,3,7,8-Tetrachlorodibenzo-(italic)p(/italic)-dioxin (TCDD or dioxin), a widespread environmental contaminant, has been shown to disrupt multiple endocrine pathways. The International Agency for Research on Cancer classified TCDD as a known human carcinogen, primarily based on occupational studies of increased mortality from all cancers combined. Using data from the Seveso Women's Health Study (SWHS), we examined the association between individual serum TCDD levels and breast cancer risk in women residing around Seveso, Italy, in 1976, at the time of an industrial explosion that resulted in the highest known population exposure to TCDD. The SWHS cohort comprises 981 women who were infants to 40 years old in 1976, resided in the most contaminated areas at the time of the explosion, and had archived sera that was collected soon after the explosion. For each woman, serum TCDD exposure was measured by high-resolution mass spectrometry. Cancer cases were identified during interview and confirmed by medical record. At interview, 15 women (1.5%) had been diagnosed with breast cancer and serum TCDD levels for cases ranged from 13 to 1,960 ppt. Cox proportional hazards modeling showed that the hazard ratio for breast cancer associated with a 10-fold increase in serum TCDD levels (log(subscript)10(/subscript) TCDD) was significantly increased to 2.1 (95% confidence interval, 1.0-4.6). Covariate-adjusted results were not different. Individual serum TCDD is significantly related with breast cancer incidence among women in the SWHS cohort. Continued follow-up of the cohort will help shed light on the possible role of TCDD in the pathogenesis of breast cancer.
Handbook of Contemporary Neuropharmacology
Authors: Walter A. Brown, David A. Solomon, Arif Khan
Journal: JAMA (2007)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Internal Medicine and Training in Allergy
Authors: DAVID M. LANG
Journal: Annals of Internal Medicine (1985)

Letters and Corrections1 November 1985Internal Medicine and Training in AllergyDAVID M. LANG, M.D.DAVID M. LANG, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-103-5-809_2 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: I read with interest the editorial by Fink and Patterson (1) and the response by Gross (2). Since then I have gone from being an internal medicine "gatekeeper" to an allergy/immunology fellow. Although I feel that Dr. Gross' comments were apropos, I can also empathize with views expressed in the editorial (1). Certain aspects of allergy practice mentioned by these authors merit further emphasis.Allergy is a unique field for many reasons that set it apart from other subspecialties of internal medicine. As mentioned by Fink and Patterson, training in allergy during internal medicine residency lacks the...References1. FINKPATTERSON JR. Responsibility of the primary care internist in the care of the allergic patient [Editorial]. Ann Intern Med. 1985;102:263-4. LinkGoogle Scholar2. GROSS R. Referrals to allergists [Letter]. Ann Intern Med. 1985;102:726. LinkGoogle Scholar3. REISMAN R. American Academy of Allergy: position statements—controversial techniques. J Allergy Clin Immunol. 1981;67:333-8. CrossrefMedlineGoogle Scholar4. MATHEWS K. Claims of medical cures by clinical ecologists based on unscientific evidence. Ann Arbor News. 1985; 26 July. Google Scholar5. TERRWEISSKOPFSPARACINO AAR. Allergy practice in California—diagnostic and therapeutic methods used by allergists and otolaryngologists. West J Med. 1985;143:276-9. MedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: DAVID M. LANG, M.D.Affiliations: Scripps Clinic and Research Foundation La Jolla, CA 92037 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 November 1985Volume 103, Issue 5Page: 809-809KeywordsAllergy and immunologyResidencySub-specialty care ePublished: 1 December 2008 Issue Published: 1 November 1985 PDF downloadLoading ...
Total Body Potassium in Long-Term Frusemide Therapy: Is Potassium Supplementation Necessary?
Authors: H. J. Dargie, K. Boddy, A. C. Kennedy, P. C. King, P. R. Read, D. M. Ward
Journal: BMJ (1974)

Measurements of total body potassium (T.B.K.) were made by whole-body counting in four groups of patients receiving oral frusemide for one year. Patients in group 1 had essential hypertension and normal renal function and received 40 mg frusemide daily without potassium supplements. Patients in group 2 were similar but received oral potassium supplements for the first four months of treatment. Patients in group 3 had hypertension associated with renal disease and received 120 mg frusemide daily without potassium supplements. Patients in group 4 also had hypertension and renal impairment and in addition to 120 mg frusemide daily they received oral potassium supplements for four months. No evidence of depletion of T.B.K. was found in any of the groups after continuous treatment with frusemide for one year. It is questioned whether potassium supplementation in long term diuretic therapy with frusemide is necessary unless there is evidence of pre-existing potassium depletion or of some other factor such as cardiac failure, cirrhosis of the liver, or the nephrotic syndrome.
International Committee of Medical Journal Editors' Definition of a Clinical Trial
Authors: Christine Laine
Journal: Annals of Internal Medicine (2005)

Letters6 December 2005International Committee of Medical Journal Editors' Definition of a Clinical TrialChristine Laine, MD, MPH, Senior Deputy EditorChristine Laine, MD, MPH, Senior Deputy EditorSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-143-11-200512060-00024 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail IN RESPONSE:The editors of Annals of Internal Medicine wholeheartedly agree with Dr. Campillo-Artero's statements about the supremacy of randomized, controlled trials over trials that do not use random assignment. However, because the goal of the ICMJE policy on trials registration was to promote accessibility to clinically directive experimental research, the committee adopted a broad definition of clinical trials (1). Of note, the Ottawa Group, working closely with the World Health Organization to promote comprehensive trials registration, defines trials in an even broader manner than does the ICMJE. According to the Ottawa Group (2), trial refers to “a prospective controlled ...References1. De Angelis C, Drazen JM, Frizelle FA, Haug C, Hoey J, Horton R, et al. Clinical trial registration: a statement from the International Committee of Medical Journal Editors [Editorial]. Ann Intern Med. 2004;141:477-8. [PMID: 15355883] LinkGoogle Scholar2. Krleza-Jeric K, Chan AW, Dickersin K, Sim I, Grimshaw J, Gluud C. Principles for international registration of protocol information and results from human trials of health related interventions: Ottawa statement (part 1). BMJ. 2005;330:956-8. [PMID: 15845980] CrossrefMedlineGoogle Scholar Author, Article, and Disclosure InformationAuthors: Christine Laine, MD, MPH, Senior Deputy EditorDisclosures: None disclosed. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoClinical Trial Registration: A Statement from the International Committee of Medical Journal Editors Catherine De Angelis , Jeffrey M. Drazen , Frank A. Frizelle , Charlotte Haug , John Hoey , Richard Horton , Sheldon Kotzin , Christine Laine , Ana Marusic , A. John P.M. Overbeke , Torben V. Schroeder , Harold C. Sox , and Martin B. Van Der Weyden Is This Clinical Trial Fully Registered? Catherine D. De Angelis , Jeffrey M. Drazen , Prof Frank A. Frizelle , Charlotte Haug , John Hoey , Richard Horton , Sheldon Kotzin , Christine Laine , Ana Marusic , A. John P.M. Overbeke , Torben V. Schroeder , Harold C. Sox , and Martin B. Van Der Weyden International Committee of Medical Journal Editors' Definition of a Clinical Trial Carlos Campillo-Artero Metrics 6 December 2005Volume 143, Issue 11Page: 847KeywordsClinical trialsConflicts of interestGlobal healthHealth information technology ePublished: 6 December 2005 Issue Published: 6 December 2005 Copyright & PermissionsCopyright © 2005 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Analysis of association of the TIRAP (MAL) S180L variant and tuberculosis in three populations
Authors: Sergey Nejentsev, Thorsten Thye, Jeffrey S Szeszko, Helen Stevens, Yanina Balabanova, Amanua M Chinbuah, Martin Hibberd, Esther van de Vosse, Bachti Alisjahbana, Reinout van Crevel, Tom H M Ottenhoff, Eileen Png, Francis Drobniewski, John A Todd, Mark Seielstad, Rolf D Horstmann
Journal: Nature Genetics (2008)
CIRCULATING SOLUBLE RECEPTOR FOR ADVANCED GLYCATION END PRODUCTS IS RELATED TO ALBUMINURIA IN HYPERTENSION
Authors: Konstantinos P. Tsioufis, K. Dimitriadis, A. Agelis, M. Poulakis, A. Kefala, A. Kasiakogias, A. Miliou, M. Almiroudi, C. Stefanadis
Journal: Journal of the American College of Cardiology (2011)
Electric Convulsion Therapy
Authors: S. M. Whitteridge
Journal: BMJ (1947)

and also in primary suppurative meningitis due to the pneumo- coccus and nmany due to H. influenzae (Pfeiffer) is not ques- tioned, but in meningococcal cases its superiority to oral and systemic sulphonamides has not been established, and its use is attended with unjustifiable risks.-Iam, etc.,
The first <i>COL7A1</i> mutation survey in a large Spanish dystrophic epidermolysis bullosa cohort: c.6527insC disclosed as an unusually recurrent mutation
Authors: M.J. Escámez, M. García, N. Cuadrado-Corrales, S.G. Llames, A. Charlesworth, N. De Luca, N. Illera, C. Sánchez-Jimeno, A. Holguín, B. Duarte, M.J. Trujillo-Tiebas, J.L. Vicario, J.L. Santiago, A. Hernández-Martín, A. Torrelo, D. Castiglia, C. Ayuso, F. Larcher, J.L. Jorcano, A. Meana, G. Meneguzzi, G. Zambruno, M. Del Rio
Journal: British Journal of Dermatology (2010)

Background Dystrophic epidermolysis bullosa (DEB) is a genodermatosis caused by mutations in COL7A1. The clinical manifestations are highly variable from nail dystrophy to life-threatening blistering, making early molecular diagnosis and prognosis of utmost importance for the affected families. Mutation identification is mandatory for prenatal testing. Objectives To conduct the first mutational analysis of COL7A1 in a Spanish cohort, to assess mutation consequences at protein/mRNA level and to establish genotype–phenotype correlations. Methods Forty-nine Spanish patients with DEB were studied. Antigen mapping was performed on patient skin biopsies. COL7A1 mutation screening in genomic DNA was performed by polymerase chain reaction (PCR) and direct sequencing. Mutation consequences were determined by reverse transcriptase-PCR. Results Eight patients belonged to three unrelated families with dominant DEB. Forty-one were affected with recessive DEB (RDEB). Specifically, 27 displayed the severe generalized subtype, eight the other generalized subtype and six a localized phenotype (two pretibial, three acral and one inversa). Thirty-five mutations were identified, 20 of which are novel. The pathogenic mutation c.6527insC accounted for 46·3% of Spanish RDEB alleles. A consistent genotype–phenotype correlation was established. Conclusions Although the COL7A1 database indicates that most DEB mutations are family specific, the pathogenic mutation c.6527insC was highly recurrent in our cohort. This level of recurrence for a single genetic defect has never previously been reported for COL7A1. Our findings are essential to the clinicians caring for patients with DEB in Spain and in the large population of Spanish descendants in Latin America. They also provide geneticists a molecular clue for a priority mutation screening strategy.
Unreliable Wassermann Reactions
Authors: William A. Pusey
Journal: JAMA (1913)

Report of the Council on Pharmacy and Chemistry Veroform Germicide is described in New and Noiiollicial Remedies, 1913, as a solution produced by dissolving formal- dehyd gas in a solution of soap.It is claimed to contain 20 per cent, of forinahlehyd.The claimed germicida] action of this preparation appearing improbable in the light of the investigations of disinfectants made by the Hygienic Labora- tory of the U. S. Public Health Service, the owners of Vero- form Germicide were asked to substantiate their claims.Such evidence not having been produced, the council voted that